bluuebunny/crossref_metadata_2025 huggingface dataset:
[Retracted] Compound Shuganjieyu Capsule on CYP450 Enzyme Activity
Authors: Tang Yunqiu , Li Yunxia
Published: October 2022

Objective. To evaluate the potential drug‐drug interactions of the Shuganjieyu capsule by establishing a Chronic Unpredictable Mild Stress (CUMS) depression model combined with the Cocktail probe substrate method. Methods. The whole study was divided into the single‐dose and multiple‐dose groups. Animals were randomly divided into further subgroups in each group. Following chronic unpredictable mild stress model development, Shuganjieyu capsules were administered to the drug administration group. The single‐dose subgroup received the drug for one day, and the multiple‐dose subgroup received the drug for three months. Liver microsomes of each group were extracted, and the effects of the Shuganjieyu capsule on the CYP450 enzyme were investigated by liquid chromatography‐mass spectrometry (LC‐MS) (LC‐MS) based on the Cocktail probe substrate method. The immunohistochemical method and RT‐qPCR were used to detect the activity of CYP450 immunoprotein in rat liver. Results. In the single‐dose subgroup, there were no statistical differences between the administration and model groups. In the multiple‐dose subgroup, the conversion and protein expression rates of CYP1A2 and CYP2C19 were significantly increased in the model group compared with the blank group. In the administration group, the conversion and protein expression rates of CYP1A2 and CYP2C19 were inhibited. Conclusion. Long‐term administration of the Shuganjieyu capsule could relieve depression‐related behaviors in CUMS rats and downregulate the CYP1A2 and CYP2C19 enzyme activities in CUMS rats by inhibiting the expression of CYP1A2 and CYP2C19 protein. Long‐term administration of the Shuganjieyu capsule may affect the bioavailability of other drugs metabolized by CYP1A2 and CYP2C19 enzymes, but the clinical guidance’s specific significance needs to be clarified further.
[Retracted] Identification of RPS7 as the Biomarker of Ferroptosis in Acute Kidney Injury
Authors: Zhang Hao , Liu Xuemei , Zhou Lizhi , Deng Zebin , Wang Yinhuai
Published: October 2022

Objective. This paper aims to explore novel ferroptosis‐related biomarkers for acute kidney injury (AKI). Methods. Various bioinformatic methods, such as differential expression analysis, functional annotation analysis, machine learning, and chemical‐gene network analysis, were used in this study. Furthermore, the expression and proferroptotic role of RPS7 were validated with further bioinformatics analysis and biochemical experiments. Results. GSE30718 dataset and GSE139061 dataset were used, and the differentially expressed genes (DEGs) were screened. The DEGs were overlapped with ferroptosis‐related genes and genes associated with AKI, which led to the identification of four candidate genes. Machine learning and ROC curve analysis were conducted, and RPS7 and TRIB3 were selected for diagnostic model analysis and functional analysis. Finally, the upregulation of RSP7 in cisplatin‐induced AKI was validated in cisplatin‐induced AKI, and its proferroptotic role was confirmed in cisplatin‐treated proximal tubular cells. Conclusion. Our results indicated that RPS7 might present as a novel ferroptosis‐related biomarker for AKI, and it derived ferroptosis to accentuate cisplatin‐induced AKI.
IoT Applications in the Innovation System of Enterprise Human Resource Performance Management Based on the Integration of Big Data
Authors: Xiao Jie
Published: October 2022

Under the pattern of financial globalization, execution the executives has drawn in a great deal of consideration from scholarly and industry. Related empowering innovations make the human asset execution the executives business smarter. As one of the vital innovations in man-made brainpower, huge information-driven examination further develops the presentation seriousness of human asset industry by mining the secret information worth and expected capacity of modern huge information and assists undertaking pioneers using sound judgment in different complex human asset execution the executives conditions. This paper gives a hypothetical examination premise to large-information-driven innovation to direct decision-production in human asset execution the board, completely exhibiting the practicability of enormous information-driven innovation in the astute human asset execution the executives, including key benefits and interior inspiration. A reasonable system of smart dynamic in view of modern enormous information-driven innovation is proposed in this review, which gives important experiences and musings to the serious difficulties and future examination bearings in this field.
Application of Chinese Classical Garden Landscaping Techniques in Modern Indoor Natural Landscape Design from the Perspective of Virtual Reality Technology
Authors: Tian Lin
Published: October 2022

In the multimedia information comprehensive development of multimedia culture, the traditional technology of many industries and advanced mobile technology develop in concert. Ancient Chinese gardens have a long history. They are rich in content, outstanding in style, and full of characteristics. They have great aesthetic value and are the valuable property of all mankind. This paper discusses the environmental expression, spatial layout, and element combination in traditional garden art. The study of landscape design techniques involves different subjects. Through the developed mobile multimedia information, the traditional garden design is more rich, separation but not blocking, desire to promote first restraint, twists and turns, appropriate scale, borrowing from afar and borrowing from neighbors. The application of these expression techniques in modern interior design is of great significance. By using the ancient gardens of our country to reflect the civilization products of our country in a certain historical stage, the paper traces its development ideas and motives and analyzes the consistency with the corresponding contemporary ideological development. From the perspective of space design, this paper discusses the influence of ancient gardens on contemporary space creation from the aspects of space type, structure form, and space language. How to apply the reference means of ancient Chinese garden design to modern interior decoration through multimedia information so that the interior space can also experience the aesthetic pleasure of “changing scenery” so that the traditional landscape and modern interior decoration can be more fully integrated. This is something designers have to think about. Chinese ancient gardens have always been the focus of domestic design circles. Both the ideas behind it and its own gardening techniques can be used for reference by contemporary interior design. Therefore, the main content of this paper is the foundation of the transformation mechanism of traditional garden in contemporary design through multimedia information. Based on the framework system of contemporary indoor natural landscape or indoor natural landscape as the background, this paper discusses how to use virtual reality technology for reference to the gardening techniques of classical Chinese gardens.
Evaluation of Multimedia Physical Education Teaching Quality considering Data Analysis Model
Authors: Han Tao
Published: October 2022

The 21st century is in the era of information explosion, the level of information technology is also increasing day by day, and the fields of its application are also wider and wider. As a new classroom teaching method that relies on information technology, multimedia teaching has become an important knowledge transfer method in colleges and universities. As a practical major, physical education (PE) often uses multimedia teaching in teaching. However, in many schools, the advantages of multimedia PE have not been fully exerted, which also makes the quality of multimedia PE not high. For the purpose of providing solutions to the problems existing in the current multimedia PE teaching, based on the characteristics and requirements of multimedia PE classroom teaching, this paper selected teachers and students from a college of PE to conduct interviews and questionnaires. Through the theoretical analysis of quality evaluation and the introduction of research methods, the evaluation indicators and weights of multimedia physical education teaching quality were determined, and the quality evaluation model of multimedia PE teaching in this university was established, and the practical application analysis was carried out. After determining the quality evaluation indicators and weights of multimedia PE, the actual application analysis included the evaluation of teachers with different titles and genders, as well as the evaluation of teachers by students of different grades. According to the assessment results, students’ evaluation of teaching quality was not obvious in terms of teachers’ gender, but there were differences in professional titles. Among them, associate professors had the highest evaluation score of 82.14, and students of different grades had different evaluations of teachers. The empirical analysis proves that the evaluation index and data analysis model of this paper have research significance.
Effects of Hemp Sanitary Pads on the Vaginal Microecology
Authors: Sun Yange , Li Chao , Yan Yan , Lai Ailuan , Peng Xiaoxiao , Yue Xiaohong , Li Yanling , Liu Junzhuo , Liu Yan
Published: October 2022

Objective. To evaluate the effect of hemp cotton sanitary pads on the vaginal microecology. Methods. A randomized controlled field trial was used to recruit 1002 community-based women of childbearing age. The women were randomly divided into experimental and control groups. The experimental group used hemp cotton sanitary pads, while the control group used two types of cotton sanitary randomly chosen from the top five sanitary pads in terms of market share in China. The vaginal microecology was compared between the two groups after three months. Results. According to the vaginal microecologic examination results at baseline, 1002 women were included in 3 groups: normal vaginal microecologic, vaginal microecological disorders, and suspected vaginal infections. The number of patients in three groups were 39 (3.9%), 652 (65.1%), and 311 (31%), respectively. Three months later, the vaginal microecologic status and vaginal pH value of the suspected vaginal infection group were not significantly different between the experimental group and control group. The experimental group outperformed the control group with respect to vaginal cleanliness and vaginal microecology status in the women without a vaginal infection (normal vaginal microecology or microecological disorders group). The rate of abnormal cleanliness in the experimental group was lower than the control group (31.95% [108/338] vs. 43.62% [154/353]). The incidence of suspected vaginitis in the experimental group was lower than the control group (15.29% [51/338] vs. 23.51% [83/353]). Conclusion. For women without vaginal inflammation, the use of hemp cotton sanitary pads during menstruation can help maintain the balance of the vaginal microecology to prevent reproductive tract infections.
Preschool Education Based on Computer Information Technology Literacy and Big Data
Authors: Luo Lan
Published: October 2022

In this practical framework, the preschool teacher is reinforced to utilize a more significant teaching model, like forming real-time-based contextual issues, to help participants to identify a deep learning-based learning model. Numerous studies have been released as a result of the popularity of the use of CIT in preschool education as a research subject. Due to the fact that it broadens teaching resources, provides learning time flexibility, and strengthens teacher-student relationships, this teaching method has received a lot of attention in academia. Teaching strategies in preschool classrooms combine elements of both direct instruction and free play. Among these, CIT stands out as a powerful tool for boosting students’ motivation and engagement in the classroom. Integrate new technology and science into the classroom setting, as well as implement pedagogical changes that make use of IT. Preschool education informatization is now deploying new technology in a variety of preschools, yet there are still flaws. In this paper, a theoretical and problematic-based classifier model, a deep learning-based methodology that was reinforced by utilising a Python-based model to create the comprehensive among preschool students and high-phase semantic parameters, and to enhance computer-based teaching through estimation and text design that can detect high-frequency-based knowledge samples, are used. In this practical model, teachers are insisted to utilize significant frameworks like contextual issues to provide skills to students. The results show that this integrated CIT teaching method is suitable for students and able to raise their aptitude and enthusiasm for studying. By offering new theoretical and practical results about preschool education, the study helps to reform preschool education.
Comprehensive Evaluation Method of Supply Chain Logistics System Quality Based on 3D Image Processing Technology
Authors: Xu Dan , Qi Jiasheng
Published: October 2022

With the rise of manufacturing informatization, many transactions are conducted on the Internet, but the final form of transaction completion is the transaction of actual products, which makes the logistics industry emerge as the times require. How to achieve the optimal allocation scheme and the fastest efficiency in the supply chain has become an urgent problem to be solved. This paper considers the characteristics and advantages of 3D image processing technology, describes the characteristics of 3D image processing supply chain (SC), and analyzes the channels that 3D image technology affects SC. Combining the respective characteristics of fuzzy theory and grey theory, the two theories are combined to develop strengths and circumvent weaknesses to form grey fuzzy theory. Comprehensive evaluation of supply chain logistics capability can achieve better evaluation results. The application of grey theory in this chapter includes constructing the factor set of the evaluation index system and determining the weight matrix of the factor set with the game method. The grey fuzzy evaluation weight matrix (i.e., single index evaluation result) is determined with the grey theory, and the fuzzy comprehensive evaluation result is finally calculated. This paper studies the supply chain logistics capability evaluation and optimization system from the aspects of system analysis, system function module design, and system architecture design and analyzes the overall goal, demand, feasibility, system business process, and data flow of the system construction. At the same time, this paper designs the supply chain logistics capability evaluation and optimization system and shows some functional interfaces. It is of great significance to improve the responsiveness, total inventory level, total cost level, supply chain performance, agility, and flexibility of the supply chain in the new environment.
A Machine Learning Algorithm for Supplier Credit Risk Assessment Based on Supply Chain Management
Authors: Wei Yuqian
Published: October 2022

In today’s complex and ever-changing world, a distribution network in lending impact analysis is an evaluation of a client’s procedures, rules, and financial well-being to evaluate as considerable risk and it provides to the contracting company. A creditor’s capability to pay the current lender’s obligations is considered while doing a lender’s threat assessment. Traditionally, it refers to the concern that the borrower may not be able to collect the sequence and interest. The challenges in lenders’ threat assessment are a lack of adequate data storage and retrieval, problematic delays caused by a lack of access to the relevant data at the right time, extended lead times that lead their shipments at risk, and demand for speedier deliveries. This paper introduces a machine learning-based linear regression algorithm (ML-LRA) for supplier credit risk (SCR) assessment based on supply chain management (SCM) in credit risk frameworks that depend significantly on modeling ML. Regression models are logistical constraints that can be used to simulate the impacts of multiple variables on a customer’s creditworthiness. The chain of distribution forecasting tool assesses specific decisions based on assumptions in variability. As a result of the findings in this study, it can be assumed that ML-LR approaches have a significant role in a variety of business processes such as supplier selection, risk prediction along with the supply chain, and demand and sales estimation. Finally, the study’s consequences for the most critical constraints and obstacles are examined to enhance the supply chain management system and ensure overall system sustainability.
The Advance on Frontotemporal Dementia (FTD)’s Neuropathology and Molecular Genetics
Authors: Wang Jindong , Wang Bailing , Zhou Tiantian
Published: October 2022

The morbidity of frontotemporal dementia (FTD), one of the most prevalent dementias praccox, is second to Alzheimer disease (AD). It is different with AD that FTD has a rapider course and a higher mortality. FTD has not yet been fully understood in terms of etiology or pathogenesis, but genetic factors are believed to be involved. In this paper, we were committed to providing a comprehensive overview to FTD in aspects of the neuropathology features and the relevant molecular genetics advances, so that there would be insights to those researchers in search of novel approaches in FTD diagnosis and treatment.
Identification and Development of an Age-Related Classification and Signature to Predict Prognosis and Immune Landscape in Osteosarcoma
Authors: Hong Jinjiong , Wang Xiaofeng , Yu Liang , Li Jie , Hu Haoliang , Mao Weisheng
Published: October 2022

Background. In childhood and adolescence, the prevailing bone tumor is osteosarcoma associated with frequent recurrence and lung metastasis. This research focused on predicting the survival and immune landscape of osteosarcoma by developing a prognostic signature and establishing aging-related genes (ARGs) subtypes. Methods. The training group comprised of the transcriptomic and associated clinical data of 84 patients with osteosarcoma accessed at the TARGET database and the validation group consisted of 53 patients from GSE21257. The aging-related subtypes were identified using unsupervised consensus clustering analysis. The ARG signature was developed utilizing multivariate Cox analysis and LASSO regression. The prognostic value was assessed using the univariate and multivariate Cox analyses, Kaplan-Meier plotter, time-dependent ROC curve, and nomogram. The functional enrichment analyses were performed by GSEA, GO, and KEGG analysis, while the ssGSEA, ESTIMATE, and CIBERSORT analyses were conducted to reveal the immune landscape in osteosarcoma. Results. The two clusters of osteosarcoma patients formed based on 543 ARGs, depicted a considerable difference in the tumor microenvironment, and the overall survival and immune cell infiltration rate varied as well. Among these, the selected 23 ARGs were utilized for the construction of an efficient predictive prognostic signature for the overall survival prediction. The testing in the validation group of osteosarcoma patients confirmed the status of the high-risk score as an independent indicator for poor prognosis, which was already identified as such using the univariate and multivariate Cox analyses. Furthermore, the ARG signature could distinguish different immune-related functions, infiltration status of immune cells, and tumor microenvironment, as well as predict the immunotherapy response of osteosarcoma patients. Conclusion. The aging-related subtypes were identified and a prognostic signature was developed in this research, which determined different prognoses and allowed for treatment of osteosarcoma patients to be tailored. Additionally, the immunotherapeutic response of individuals with osteosarcoma could also be predicted by the ARG signature.
Early Identification of High-Risk Factors for Upper Gastrointestinal Bleeding
Authors: Jin Xuesong , Wang Xiaohong , Mao Pengfei
Published: October 2022

Objective. To identify simple and accurate pre-endoscopy risk factors for early identification of high-risk upper gastrointestinal bleeding. Methods. Patients who were admitted to Suzhou Hospital of Integrated Traditional Chinese and Western Medicine from January 1, 2016, to December 31, 2019, due to upper gastrointestinal bleeding were retrieved, and the detailed clinical data of the above patients were collected. Patients with a definite diagnosis of bleeding from esophageal/and gastric varices were assigned to the high-risk group. Patients with bleeding not caused by varices were divided into a high-risk and a low-risk group according to the Forrest grading and scoring standard (high-risk group Forrest Ia-IIb, low-risk group Forrest IIc-III). Univariate analysis, t-test, chi-square test, binary logistic regression, ROC curve (Receiver-operating characteristic curve), etc. were employed for analysis in order to identify some simple and accurate risk factors for high-risk upper digestion tract bleeding before endoscopy. Results. A total of 916 patients were collected. Three risk factors among the screened risk factors (1) hemoglobin ≤ 85 g/L, (2) vomiting red blood, and (3) “red bloody stool” were analyzed by ROC curve analysis. The specificities of each factor were 78.4%, 94.5%, and 96.7%, respectively, and the sensitivities were 71.8%, 55.9%, and 23.1%, respectively. We also derived a risk prediction scoring system for the three factors that meet the high risk such as (1) hemoglobin ≤ 83 g/L, (2)vomiting red blood, and (3) “red bloody stool.” The area under the ROC curve (AUROC), sensitivity, and specificity were 0.877, 0.904, and 0.746. Conclusion. Hemoglobin ≤ 85 g/L, vomiting red blood, and red bloody stool were included in a simple scoring standard for predicting high-risk UGIB patients before endoscopy. The new risk prediction scoring system requires only three indicators and has the advantages of high accuracy, short time-consuming, and easy application.
Construction of Rural E-Commerce Logistics Service Quality Evaluation System and IoT Applications under the Background of New Retail
Authors: Yang Shanfeng
Published: October 2022

How to build a quality evaluation system for local e-commerce logistics services has been studied against the backdrop of new retailers, and how to evaluate the quality of logistics services has been standardized by updating the quality control mode for local e-commerce logistics services will be done. An evaluation index and a nearby e-commerce logistics service quality evaluation system have been established. Finally, according to the survey, the proposed quality evaluation system for local e-commerce logistics services is highly practical, enabling faster logistics transportation while minimizing usage, and the quality of local e-commerce logistics services can be effectively improved.
SIRT6 Prevents Glucocorticoid-Induced Osteonecrosis of the Femoral Head in Rats
Authors: Fang Lun , Zhang Gang , Wu Yadi , Li Zhongzhe , Gao Shan , Zhou Lu
Published: October 2022

Objective. Glucocorticoid-induced osteonecrosis of the femoral head is one of the most common causes of nontraumatic osteonecrosis of the femoral head, but its exact pathogenesis remains unclear. The aim of this study was to investigate the role of SIRT6 in the maintenance of bone tissue morphology and structure, intravascular lipid metabolism, and its potential molecular mechanism in glucocorticoid-induced osteonecrosis of the femoral head. Methods. SIRT6 adenovirus was transfected into GIONFH in rats. The microstructure of rat bone was observed by micro-CT and histological staining, and the expression of bone formation-related proteins and angiogenesis-related factors was determined through western blot and immunohistochemistry. Alkaline phosphatase activity, alizarin red staining, and the expression levels of Runx2 and osteocalcin were used to evaluate the osteogenic potential. And in vitro tube formation assay and immunofluorescence were used to detect the ability of endothelial cell angiogenesis. Results. Dexamethasone significantly inhibited osteoblast differentiation, affected bone formation, and destroyed microvessel formation, increased the intracellular Fe2+ and ROS levels and induced the occurrence of ferroptosis. SIRT6 can inhibit ferroptosis and restore the ability of bone formation and angiogenesis. Conclusion. SIRT6 can inhibit the occurrence of ferroptosis, reduce the damage of vascular endothelium, and promote osteogenic differentiation, so as to prevent the occurrence of osteonecrosis of the femoral head.
Blind Estimation of GPS M-Code Signals under Noncooperative Conditions
Authors: Rui Zixuan , Ouyang Xiaofeng , Zeng Fangling , Xu Xu
Published: October 2022

In the process of Global Positioning System (GPS) modernization, M-code signals with better immunity to interference have been proposed and used in place of P(Y) signals as new authorization signals. A typical positioning, navigation, and timing (PNT) service is based on the local interrelation operation between the reference signal and the received signal. To obtain a PNT, the receiver should generate replicas of the pseudorandom code for acquisition and tracking. However, due to the use of an encryption algorithm, the receiver cannot use the M-code signal under noncooperative conditions. This paper presents an algorithm for estimating M-code sequences without prior knowledge. This algorithm adopts a waveform matching technique and a time domain filtering method to extract M-code from the in-phase channel and quadrature channel of the GPS L1 band. A high-gain antenna is used to receive GPS signals to keep the signal from being drowned out by noise. The experimental results show the feasibility of the method. Therefore, it is helpful for studying and evaluating the performance achieved without prior knowledge of the GPS signals.
[Retracted] Evaluation Method of Comprehensive Quality of Environmental Protection Teachers Based on Big Data Analysis Technology
Authors: He Wei , Zhou Weijiang
Published: October 2022

In order to improve the shortcomings that the weight of each index is easily affected by human influence in the evaluation of traditional teachers’ comprehensive literacy, on the basis of the analysis of index coefficients, feature reorganization, and feature analysis, this paper constructs the comprehensive literacy of environmental protection professional teachers’ education in the big data environment. The evaluation model is proposed, and a weight distribution scheme for teachers’ comprehensive literacy evaluation indicators is proposed based on the hierarchical Bayesian beta‐return model, so as to improve the rationality of the indicator distribution and make the prediction results more accurate. The simulation results further verify the superiority of the proposed model in improving the comprehensive quality evaluation level of environmental protection teachers.
Construction and Application of Mathematical Model of Stable Fracture Development Zone of Roof
Authors: Li Xinjian , Chen Xiangjun , Wang Lin
Published: October 2022

The fractured zone in the overlying strata of a coal mine goaf is vital for effective gas drainage. The development height of the fractured zone is lied on the “saddle type” theory and calculated by empirical formula, while the horizontal range is dependent on the caving theory of the “O” circle. However, the height of the fracture zone obtained using the above method is usually too large, and only the horizontal boundary of the fracture zone is defined. Besides, the fracture development degree in different regions is not described. To accurately determine the stable development area of the fractured zone and locate the gas migration channel as well as gas enrichment horizon, in this paper, a geometric and mathematical model for gas extraction in the fractured zone is established based on common high-level drilling. Then, a method of investigating the parameters of the directional high-level drilling in the roof is proposed, and a solving means is provided. Taking Wanfeng Coal Mine as an engineering background, the reasonable parameters of the common high-level drilling were investigated, and the effect was verified using the directional high-level drilling in the roof of an adjacent working face. The results show that the stable extraction volumes of the two directional drilling holes is 1~1.8 m3/min and 0.6~1 m3/min, respectively, which exceeds the optimal extraction volumes of the ordinary drilling holes. The new method of determining the stable development area of the fractured zone is significant for improving the gas drainage effect of the high-level drill holes in the roof.
[Retracted] Does Income Inequality Harm Green Growth? The BRICS Experience
Authors: Chen Wanling , Chen Shaoming , Tang Yuping
Published: October 2022

Green growth plays a vital role in ensuring sustainable development. Managing economic growth without disrupting the environment is considered the need of the present time. Therefore, the empirics have turned their attention toward finding the determinants of green growth. Hence, we aim to investigate the impact of income inequality on green growth in BRICS economies from 1993 to 2020. Findings of the panel autoregressive distributed lag (ARDL) model confirm that the long‐run estimate attached to GINI is negatively significant, implying that higher inequality in the BRICS economies lowers the rate of green growth. The country‐wise results highlighted the negative impact of GINI on green growth in India and China only and insignificant in other countries. In the short run, the estimates are inconclusive and mixed, be it group‐wise or individual estimates. Our findings imply that the target of lower inequality and environmental sustainability can be achieved simultaneously.
An IOT Innovation of Smart Solar Energy Consumption Analysis and Control in Micro Grid
Authors: Anantha Krishnan V. , Jeba Sheela A. , Muthuraj B. , Senthil Kumaran U. , Muni T. Vijay , Rani Tirukoti Sudha , Sripada Ramesh N. S. V. S. C. , Siddique Manzoor Hiu , Raju Raja
Published: October 2022

Solar energy consumption is a systematic study used to review the design of facilities, services, and equipment in an organization against specifications of solar panel. The solar panel energy consumption analysis is a work that should be done at the beginning of a solar energy. This way, potential changes can be highlighted before they affect the solar energy budget and schedule. The proposed model provides the IOT-based smart solar energy consumption analysis and control model by using solar photovoltaic micro grid. The proposed IOT design must meet product and process requirements. The solar panel energy should properly address important aspects of production processes. This should include risks related to product quality and safety. Finally, unacceptable risks must be minimized by design. In the solar energy consumption analysis process, the deliverables should be evaluated; customers should precheck the proposed design and identify problematic areas, if any. Solar energy consumption analysis reveals whether user requirements and features are sufficient to achieve the desired outcome. Likewise, there should be corrective actions for discrepancies found in design reviews.
Study on the Effect of B-Ultrasound NT Scan in Early Pregnancy Combined with Serum Screening in Early and Middle Pregnancy for Down Syndrome
Authors: Li Li , Ma Cen , Sun Lingyan
Published: October 2022

Objective. Down syndrome (DS), also known as trisomy 21 syndrome, is a common and most harmful congenital chromosomal genetic disease. This study is aimed at exploring the effect of B-ultrasound NT scan in early pregnancy combined with serum screening in early and middle pregnancy for Down syndrome. Methods. A total of 168 pregnant women who were diagnosed and treated in the obstetric clinic of our hospital from January 2019 to December 2021 were selected as the research objects. B-ultrasound NT scanning and serum detection in the early and middle trimester of pregnancy were performed, respectively. The accuracy of single detection and combined detection was analyzed and compared with the results of amniotic fluid cell chromosome examination as the gold standard. Results. There were 4 cases of DS and 165 cases of non-DS. The serum PAPP-A, AFP, and UE levels in DS group were lower than those in non-DS group. β-HCG level and NT value were higher than those in non-DS group (all

p
<
0.05

). Among 168 pregnant women, 5 cases were diagnosed as abnormal by ultrasonography, and 1 case was diagnosed as normal. By serological test, 20 cases with high risk of DS were diagnosed in 4 cases, and 148 cases with low risk of DS were diagnosed in 2 cases. Among 168 cases examined by serology combined with ultrasound, 10 cases with high risk of DS were found, and 4 cases were diagnosed; 158 cases had low risk of DS, and 0 cases were diagnosed. The negative predictive value, specificity, and coincidence rate of DS screening by the three methods were higher, and the positive predictive value and coincidence rate of combined screening were the highest (

p
<
0.05

). The screening risk of Down syndrome was correlated with pregnancy outcome. The abnormal pregnancy rate in high-risk group was significantly higher than that in low-risk group, and the difference was statistically significant (

p
<
0.05

). ROC curve showed that the sensitivity, specificity, and AUC of the combined detection were greater than those of serology and NT. Conclusion. The application of B-ultrasound NT scan in early pregnancy combined with early and mid-term serum comprehensive screening in the screening of Down’s infants is helpful to improve the diagnostic coincidence rate and reduce the occurrence of misdiagnosis.
The Applicability of Provocative Functional Tests in the Diagnosis of Rotator Cuff Muscle Injuries of the Best University Athletes
Authors: Ujsasi Darijan , Filipović Karmela , Zvekić-Svorcan Jelena , Nemet Marko , Đuričin Aleksandar , Jokšić-Mazinjanin Radojka , Pavlović Slobodan , Jovanović Saša , Popović Boris , Štajer Valdemar , Radanović Danilo , Marinković Dragan , Cvetković Milan
Published: October 2022

Rotator cuff disease, external and internal impingement syndromes, low shoulder stability, various types of trauma, and overuse injuries are all related to sports activities. In order to check symptoms in patients with disability and shoulder pain, clinicians use different methods and diagnostic imaging assessment. The research is aimed at evaluating whether there is a difference between provocation function tests (PFT) and ultrasonographic (US) testing of muscles within the rotator cuff in elite collegiate athletes. Patients (n = 184) were recruited from university team sports selections and tested with a standardized US examination of the shoulder and five PFTs (Speed’s test, Neer’s test, Hawkins test, lift‐off test, Yergason’s test). Based on the VAS pain assessment scale, 60 subjects had some pain, which was taken for further processing in the work (124 subjects did not have the presence of pain and were excluded from further processing). The US examination was conducted using Voluson 730 apparatus, by a linear probe, with the frequency in the range of 6‐12 MHz. The chi‐square test showed significant differences between PFT and the occurrence of shoulder muscle tendinitis for the following variables: Speed’s test and subscapularis tendinitis (p = 0.02) and Speed’s test and infraspinatus tendinitis (p = 0.01); Neer test and biceps brachii caput longum tendinitis (p = 0.01), Neer test and supraspinatus tendinitis (p = 0.02) and Neer test and infraspinatus tendinitis (p = 0.01); lift‐off test and subscapularis tendinitis (p = 0.05); and Yergason’s test and biceps brachii caput longum tendinitis (p = 0.03) and Yergason’s test and subscapitis tendinitis (p = 0.01). The greatest effect of differences was observed in Neer’s test and biceps brachii caput longum tendinitis (φ = 0.60), while the other effects can be described as medium and small in most cases. It can be concluded that functional tests are good predictors of soft tissue changes in the muscles of the rotator cuff of the shoulder. Further monitoring and analysis are needed on a larger number of athletes.
Application of Intelligent Signal Reflection in the Communication Model of an Electronic Controller
Authors: Lan Lan
Published: October 2022

This paper analyses the automatic control effect of an electronic controller, combined with artificial intelligence technology in order to improve the automatic control of an electronic controller. In order to improve the automatic control effect of the electronic controller, a novel centralized intelligent reflective surface-assisted millimeter-wave computational imaging scheme based on pixel block division and block sparse signal recovery is proposed in this paper. Meanwhile, this paper proposes a fast block-sparse Bayesian learning algorithm. It combines the GAMP algorithm with machine learning, so it can achieve similar performance with much lower computational complexity than the traditional block sparse Bayesian learning algorithm. The simulation clustering study shows that the electronic controller automation system based on artificial intelligence technology proposed in this paper can effectively improve the control effect of the electronic controller.
Changes in Cross-Sectional Area of the Median Nerve and Body Composition Parameters after Treatment of Acromegaly: 1 year Follow-Up
Authors: Ságová Ivana , Kantárová Daniela , Mokáň Marián , Vaňuga Peter
Published: October 2022

Objective. Median neuropathy is a common manifestation of acromegaly, although its pathology is uncertain. Changes in levels of growth hormone (GH) and insulin-like growth factor I (IGF-I) and body composition are potential parameters in pathology of median neuropathy in acromegaly. We aimed to assess changes in the cross-sectional area (CSA) of the median nerve and body composition in newly diagnosed acromegalic patients 1 year after treatment and to determine their mutual relationships. Design. This prospective study included 30 patients with newly diagnosed acromegaly and 30 healthy controls matched for age, gender, and body mass index. Physical and laboratory examinations, dual-energy X-ray absorptiometry (DXA), and ultrasound evaluations were performed at baseline and 1 year after initial treatment. Results. The CSA of the median nerve was increased in acromegalic patients compared with controls (13.1 mm2 [12.2–14.9] vs 7.5 mm2 [6.4–8.4],

P
<
0.001

). One year after treatment of acromegaly, GH and IGF-I levels decreased significantly. The median nerve CSA was significantly reduced after treatment (11.6 mm2 [10.2–13.1],

P
<
0.001

). Reduction of IGF-I levels correlated with a decrease in lean mass and increase in fat mass. The median nerve CSA positively correlated with IGF-I levels (R = 0.492,

P
=
0.006

) and lean mass (R = 0.419,

P
=
0.021

) in acromegalic patients before treatment. Conclusion. This study demonstrates a reduction in the median nerve CSA 1 year after treatment of acromegaly. These changes are closely associated with a reduction in IGF- I levels and in lean body mass. The enlargement of the median nerve in acromegaly can be reversed with adequate treatment.
Identification of a miRSNP Regulatory Axis in Abdominal Aortic Aneurysm by a Network and Pathway-Based Integrative Analysis
Authors: Liu Shenrong , Liao Yanfen , Liu Changsong , Zhou Haobin , Chen Gui , Lu Weiling , Huang Zheng
Published: October 2022

Abdominal aortic aneurysm (AAA) refers to local abnormal expansion of the abdominal aorta and mostly occurs in elderly men. MicroRNA (miRNA) is single-stranded RNA consisting of 18–25 nucleotides. It plays a key role in posttranscriptional gene expression and in the regulation of human functions and disease development. miRNA exerts its function mainly through the binding of complementary base pairs to the 3

′

regulatory region of mRNA transcripts. Therefore, miRNA-related single-nucleotide polymorphisms (miRSNPs) can affect miRNA expression and processing kinetics. miRSNPs can be classified based on their location: miRSNPs within miRNA-producing genes and miRSNPs within miRNA target genes. Increasing evidence indicates that miRSNPs play an important role in the pathogenic kinetics of cardiovascular diseases. The aim of this study was to identify potential miRNAs and integrate them into a miRSNP-based disease-related pathway network, the results of which are of great significance to the interpretation of the potential mechanisms and functions of miRSNPs in the pathogenesis of diseases.
Defactinib, Pembrolizumab, and Gemcitabine in Patients with Advanced Treatment Refractory Pancreatic Cancer: A Phase I Dose Escalation and Expansion Study
Authors: Wang-Gillam Andrea , Lim Kian-Huat , McWilliams Robert , Suresh Rama , Lockhart Albert C. , Brown Amberly , Breden Marcus , Belle Jad I. , Herndon John , Bogner Savannah J. , Pedersen Katrina , Tan Benjamin , Boice Nicholas , Acharya Abhi , Abdiannia Mina , Gao Feng , Yoon Harry H. , Zhu Mojun , Trikalinos Nikolaos A. , Ratner Lee , Aranha Olivia , Hawkins William G. , Herzog Brett H. , DeNardo David G.
Published: October 2022

Purpose:

Targeting focal adhesion kinase (FAK) renders checkpoint immunotherapy effective in pancreatic ductal adenocarcinoma (PDAC) mouse model. Defactinib is a highly potent oral FAK inhibitor that has a tolerable safety profile.

Patients and Methods:

We conducted a multicenter, open-label, phase I study with dose escalation and expansion phases. In dose escalation, patients with refractory solid tumors were treated at five escalating dose levels of defactinib and gemcitabine to identify a recommended phase II dose (RP2D). In expansion phase, patients with metastatic PDAC who progressed on frontline treatment (refractory cohort) or had stable disease (SD) after at least 4 months of standard gemcitabine/nab-paclitaxel (maintenance cohort) were treated at RP2D. Pre- and posttreatment tumor biopsies were performed to evaluate tumor immunity.

Results:

The triple drug combination was well-tolerated, with no dose-limiting toxicities. Among 20 treated patients with refractory PDAC, the disease control rate (DCR) was 80%, with one partial response (PR) and 15 SDs, and the median progression-free survival (PFS) and overall survival (OS) were 3.6 and 7.8 months, respectively. Among 10 evaluable patients in the maintenance cohort, DCR was 70% with one PR and six SDs. Three patients with SD came off study due to treatment- or disease-related complications. The median PFS and OS on study treatment were 5.0 and 8.3 months, respectively.

Conclusions:

The combination of defactinib, pembrolizumab, and gemcitabine was well-tolerated and safe, had promising preliminary efficacy, and showed biomarker activity in infiltrative T lymphocytes. Efficacy of this strategy may require incorporation of more potent chemotherapy in future studies.
Phase I Dose Escalation Study of Topical Bexarotene in Women at High Risk for Breast Cancer
Authors: Thomas Parijatham S. , Patel Anisha B. , Lee J. Jack , Liu Diane D. , Hernandez Mike , Muzzio Miguel , Contreras Alejandro , Sepeda Valerie , Mays Carrie , Weber Diane , Vornik Lana A. , Khan Seema A. , Dimond Eileen , Heckman-Stoddard Brandy M. , Perloff Marjorie , Brown Powel H.
Published: October 2022

Agents that can reduce the incidence of hormone receptor negative breast cancer are currently lacking. Rexinoids such as bexarotene significantly reduced mammary tumor development in preclinical mouse models. Oral bexarotene in BRCA mutation carriers significantly decreased cyclin D1 in breast cells, suggesting biological activity on breast tissue. This study evaluated topical bexarotene 1% gel applied to one unaffected breast in women at high risk for breast cancer for 4 weeks to assess safety and toxicity. Secondary objectives included assessment of bexarotene concentrations in the plasma and breast tissue. In the dose escalation phase, women were assigned to one of three different dose levels: 10 mg (1 mL) every other day, 10 mg (1 mL) daily, 20 mg (2 mL) daily. Dose-limiting toxicity (DLT) was defined as a grade 2 skin adverse event for at least 6 days or any grade 3 or 4 adverse event related to study drug. A total of 14 women were enrolled with 10 participants at the every other day dose level and 4 participants at daily dosing. Two skin DLTs were experienced at daily dosing and therefore further enrollment was discontinued per protocol. An additional 10 participants were enrolled at the MTD as part of the dose expansion phase. These individuals tolerated the treatment with minimal adverse events. Maculopapular rash at the treatment site was the most common adverse event related to study drug and resolved within a few days of discontinuation. Bexarotene was detectable in breast tissue at the 10 mg daily every other day dose.

Prevention Relevance:

Bexarotene is a rexinoid that has been shown to prevent mammary tumors in mouse models but oral dosing has toxicities. This phase I study evaluates topical bexarotene, as a potential chemoprevention agent, for safety and toxicity in high-risk women for breast cancer.
A Ball in the Belly: Calcifying Fibrous Pseudotumor of Abdominal Cavity – A Rare Entity
Authors: Bhalla Alok , Basra Sharanjit Singh , Ghodke Sandhya , Hiremath Ravishekar Ningayya , Verma Vishal , Chourey Niraj
Published: October 2022

Calcifying fibrous pseudotumor is a rare clinically benign tumor first reported by Rosenthal and Abdul-Karim in 1988. Although rare, the tumor occurs most commonly in children and adolescents. Here we present a case of a 47-year-old male who reported to our institution with vague complaints of intermittent abdominal discomfort which was of mild to severe intensity, diffuse in presentation for a duration of 6 months. The pain was associated with subjective feeling of a “Wandering Lump” in the lower abdomen. This case report presents how this entity was managed along with review of literature. The novelty in this case report was it was a very peculiar case in the sense of its vague presentation, as the patient complained that he feels a lump and discomfort in right lower quadrant of his abdomen in the morning which moves up in the epigastric region; by evening, it comes to lie in the right lower quadrant of abdomen. So, anybody can discard this vague presentation, but in this case, we showed very high index of suspicion and evaluated him. The laparotomy confirmed its vague but true presentation as the lump was actually a freely lying ball which was wandering freely in the abdomen probably by peristalsis and patient’s routine activities. Surgical specialists are therefore advised never to miss such vague presentations, and index of suspicion has to be kept at all times.