bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS RASIO INETERNAL PERUSAHAAN YANG BERPENGARUH TERHADAP PROFITABILITAS PADA PERUSAHAAN SUB SEKTOR PERBANKAN KONVENSIONAL
Authors: Rokhayati Isnaeni
Published: March 2024

The bank's financial performance can be assessed from several indicators, one of the main indicators used as the basis for the assessment is the bank's financial statements. Based on the financial statements, a number of financial ratios can be calculated which are commonly used as a basis for assessing the soundness of a bank. Financial ratios are the results of calculations of bank financial data, which are used to explain the relationship between financial data. Financial ratios that can measure financial performance, can be referred to as internal ratios. The purpose of this study was to determine the effect of Net Interest Margin (NIM), Net Performing Loans (NPL), Loan to Deposit Ratio (LDR), and Capital Adequacy Ratio (CAR) on Return on Assets (ROA). The study uses quantitative methods by taking samples of conventional commercial banking companies listed on the Indonesia Stock Exchange from 2016 to 2018. The sampling technique in this study was purposive sampling with a sample of 19 banking companies. Data analysis techniques used descriptive analysis with panel data regression models using eviews 10. The results showed that the Net Interest Margin (NIM) had a significant positive effect on Return On Assets (ROA), so that banking companies had to keep NIM at a high ratio by maintaining loan asset quality and operating expense efficiency; Non Performing Loans (NPLs) have a significant negative effect on profitability (ROA), so as to increase Return On Assets (ROA) banking companies must keep their Net Performing Loans (NPLs) at a low ratio by suppressing the existence of problem loans through loan restructuring; Loan To Deposit Ratio (LDR) has no effect on Return On Assets (ROA), so that banking companies must increase lending so that profits from loan interest obtained will increase, but lending must be done prudentially and compliance so as not to cause non-performing loans; and Capital Adequacy Ratio (CAR) has no effect on profitability (ROA), so banks must improve efficiency and reduce problem financing.
The Factors Associated with Nomophobia Among Bachelor of Nursing Students at Universitas Muhammadiyah Purwokerto
Authors: Azzahroh Khanani , Susilo Rakhmat
Published: March 2024

Background: Mobile phones have become essential tools for students due to their ability to meet various educational demands and provide access to a wealth of information. Excessive use and dependence on smartphones have also led to a new problem known as nomophobia. Nomophobia is a term derived from the phrase "no mobile phone phobia," which is related to the fear or distress experienced by individuals when they lose or cannot use their smartphones. Objective: This study aims to determine the factors associated with nomophobia among Bachelor of Nursing students at Universitas Muhammadiyah Purwokerto. Method: This quantitative research used a cross-sectional approach. The study sample comprised 92 Bachelor of Nursing students aged 18-24, selected using stratified random sampling. Data analysis included univariate and bivariate analyses using the Chi-Square test. Results: The analysis showed an association between nomophobia and the following factors: learning fatigue with a p-value of 0.029 (less than 0.05), self-esteem with a p-value of 0.012 (less than 0.05), loneliness with a p-value of 0.035 (less than 0.05), and smartphone usage intensity with a p-value of 0.001 (less than 0.05). Conclusion: A correlation exists between learning fatigue, self-esteem, loneliness, and smartphone usage intensity with nomophobia among Bachelor of Nursing students at Universitas Muhammadiyah Purwokerto.
Factors Related to the Completeness of Electronic Surgical Safety Checklist Documentation in Banyumas Public Hospital
Authors: Sya’diyah Halimatus , Linggardini Kris
Published: March 2024

Background: Patient safety in surgery is a program established by the WHO and is a standard for accreditation by KARS, implementing the electronic surgical safety checklist. This has been proven to reduce patient safety incidents in the surgical room. Method: This quantitative research used a descriptive correlation design with a cross-sectional approach. A total sampling technique was employed, involving 34 surgical nurses in the Central Surgical Installation of RSUD Banyumas, who met the inclusion and exclusion criteria. The research instrument utilized an observation sheet based on the surgical safety checklist Standard Operating Procedure (SPO) at RSUD Banyumas. Data analysis was conducted using the chi-square test. Results: The results of the study revealed that the majority of nurses were male (70.6%), aged between 31-40 years (41.2%), and above 40 years (41.2%), with a DIII level of education (70.6%), and work experience of 1-5 years (44.1%), and they completed the electronic surgical safety checklist documentation (67.6%). Age, education level, and work experience correlate with the completeness of electronic surgical safety checklist documentation at RSUD Banyumas (p-value ? ?). Conclusion: Age, education level, and work experience related to the completeness of electronic surgical safety checklist documentation at RSUD Banyumas.
Age-Related Hypertension: A Cross-Sectional Analysis of Influencing Factors
Authors: Damayanti Arifia , Isnaini Nur
Published: March 2024

Background:Hypertension is characterized by high blood pressure, with systolic pressure above 140 mmHg and diastolic pressure above 90 mmHg, and it commonly affects the elderly population. There are two types of risk factors for hypertension, namely modifiable and non-modifiable factors. Method: This research employed a quantitative method with an analytical survey design using a case-control method. The sample size consists of 60 respondent, selected using a purposive sampling technique. Results: Statistical tests indicated a significant correlation for variables such us family history (?-value 0.0001), salt consumtion (?-value 0.0001), stress/anxiety (?-value 0.005), and compliance with a healthy lifestyle (?-value 0.003), with the occurrence of hypertension. On the other hand, age (?-value 0.278), gender (?-value 0.091), obesity status (? value 0.390), smoking status (?-value 0.243), and caffeine/coffee consumtion habits (?-value 0.196) did not show any significant correlation with hypertension occurrence. Conclusion: Family history, salt consumtion, stress/anxiety, and compliance with a healthy lifestyle are factors affecting the occurrence of hypertension in the elderly at Sokaraja 1 Public Health Care Center. However, age, gender, obesity status, smoking status, and caffeine/coffe consumtion habits do not contribute to hypertension.
Improving Discipline Character through Scouting Activities in Elementary Schools
Authors: Setyawan Arif , Wakhudin Wakhudin
Published: March 2024

Character education in scouting is believed to be able to change current problems, especially disciplinary problems This research was conducted considering the importance of student discipline character that has begun to decline, one way to improve the disciplinary character is through advanced activities. The purpose of this study is to analyze disciplinary character improvement activities carried out with scout activities along with their advantages and disadvantages.  The research method used is a qualitative approach with a case study method, using data collection techniques in the form of interviews, observations and documentation studies.  The data analysis technique used in this study is the Miles and Huberman interactive analysis model. From this research it can be concluded that scout activities can be used as a way to improve disciplinary character.
Strengthening Social Care Character in Preventing Bullying Behavior in Elementary School Through the Role of Peers
Authors: Oktarini Inah , Andriani Ana
Published: March 2024

This research was conducted considering the tendency  of bullying behavior  which has now become a phenomenon that often occurs, especially in the world of education. One way that can be done to prevent it is through the application of social caring characters with support from peers because students spend more time with their friends. This study aims to describe the processof  implementing social care characters through the role of peers in preventing bullying behavior  in schools. The method used is qualitative descriptive with a case study approach. The informants in this study were class teachers and learners. Data collection techniques through interviews, observation, and documentation studies. The  dataanalysis technique  used is the Miles and Huberman model which includes data reduction, data presentation, and conclusions. The results of the study concluded that the application of social care characters through support from peers can prevent bullying  behavior in students.
ANALISIS DAYA ELDEKTRIKAL UNIT TYPICAL PADA PROYEK APARTEMEN MENARA JAKARTA TOWER E
Authors: Yuston Yusron Amin , Lammada Ibrahim
Published: March 2024

Instalasi listrik merupakan suatu rangkaian dari peralatan listrik yang saling berhubungan antar satu dengan yang lain, dan berada dalam satu lingkup sistem ketenagalistrikan. Instalasi listrik yang lebih baik adalah instalasi yang aman bagi manusia dan akrab dengan lingkungan sekitarnya. Perencanaan sistem instalasi listrik pada suatu bangunan haruslah mengacu pada peraturan dan ketentuan yang berlaku sesuai dengan PUIL 2000 dan undang-undang ketenagalistrikan 2002. Ada beberapa hal yang perlu diperhitungkan dalam cara pemasangan instalasi listrik pada bangunan gedung seperti jarak antar titik listrik ketitik listrik lainnya, material/peralatan listrik yang dipakai, pembagian daya yang harus disesuaikan dengan kebutuhan ruangannya masing-masing. Bila semua itu dilakukan dengan cara yang tepat, maka hasilnyapun akan dirasakan langsung, yaitu kondisi aman dan nyaman selama menggunakan listrik. Pada penelitian ini menganalisis kapasitas Miniature Circuit Breaker (MCB) dan luas penampang pada suatu gedung. Hasil akhir dari penelitian ini adalah penghantar yang digunakan pada proyek apartemen Menara Jakarta telah memenuhi standar, walaupun ada yang tidak sesuai seperti pada grup stop kontak 2 pada setiap unitnya. Sedangkan untuk kapasitas pengaman, MCB yang di pasang telah memenuhi standart dan ada beberapa yang melebihi beban yang terpasang , dikarenakan kemungkinan adanya penambahan beban dikemudian hari.

 

Kata Kunci: Instalasi Listrik Gedung Bertingkat, Miniature Circuit Breaker (MCB), luas penampang, analisis kapasitas.
SIMULASI PEMODELAN BILAH UNTUK PERANCANGAN CONTROLLER TURBIN ANGIN SKALA MIKRO THE SKY DANCER 500
Authors: Naufal Abid , Latifa Ulinnuha
Published: March 2024

Indonesia merupakan negara berkembang,untuk menunjang perkembangan tersebut juga perlu di imbangi dengan ketersedian energi yang cukup. Kebutuhan akan energi dari tahun ketahun terus meningkat dengan signifikan apalagi Indonesia saat ini masih sangat bergantung khususnya pada batu bara dan minyak bumi yang suatu saat bisa habis maka diperlukannya pengembangan energi alternatif yaitu energi angin khususnya pembelajaran tentang turbin angin.  Pada proses penelitian ini penulis menggunakan metode studi literatur dengan cara mencari referensi dari jurnal atau artikel dan obeservasi langsung ke lapangan, setelah mendapatkan data – data yang diperlukan selanjutnya adalah melakukan simulasi menggunakan software PowerSimulator dan melakukan perhitungan manual menggunakan rumus. Dari kedua percobaan tersebut bertujuan untuk membandingkan dan hasilnya pada sample menggunakan data kecepatan angin 3 m/s daya yang dihasilkan dari simulasi 0,58 Watt sedangkan dari perhitungan manual sebesar 0,62 Watt. Dapat disimpulkan dari kedua percobaan tersebut hasil yang didapat hanya terdapat selisih yang tidak terlalu besar.
Pengaruh Kualitas Pelayanan Terhadap Kepuasan Pelanggan Apotek Rafa Farma 2 Surabaya
Authors: Mayang Puspita Amara  , Harsono Teguh  , Achmad Daengs GS
Published: March 2024

A pharmacy is a type of retail business whose commodities or goods traded consist of pharmaceutical supplies, which include medicines and medicinal ingredients, as well as health supplies. A pharmacy is also a specific place where pharmaceutical work is carried out and distribution of pharmaceutical supplies and other health supplies to the public. Pharmacies have two uses, namely in providing health services and in business/competition. In line with the development of science and technology in the pharmaceutical sector, there has been a shift in the orientation of pharmaceutical services and the management of drugs as a commodity to comprehensive services (pharmaceutical care) in the sense of not only managing drugs but in a broader sense includes the implementation of providing information to support the correct and rational use of drugs, monitoring drug use to determine the final destination and the possibility of medication errors (Ministry of Health, 2014).
Dampak Motivasi Terhadap Kinerja Karyawan Pada PT. Univar Limawarnane Surabaya
Authors: Dhya Nur  Aysiya  , Sugiharto Sugiharto  , Aridha Prasetya  , Bambang Karnain
Published: March 2024

The problem faced by the company PT. Univar Limawarnane Surabaya is that employee performance is not yet optimal. Reflected by the lack of optimal employee performance, namely: (1) Realization of sales of laboratory equipment is not in accordance with the targets set by the company; (2) The placement of employees is not in accordance with their competence; and (3) The workload given by the company exceeds employee capacity. As in the concept of preparing scientific work, this research aims to analyze the influence of motivation on the performance of PT employees. Univar Limawarnane in Surabaya. Meanwhile, the research sample taken was 31 people (employees), according to the size of the existing population, because the number of employees was relatively small. The data analysis technique used in this research is simple linear regression analysis. The results of the research show that there is a significant influence between motivation variables on the performance variables of PT employees. Univar Limawarnane Surabaya. This is proven t = 3.601 at Sig = 0.01 or tcount = 3.601 while t table = 2.045 This means that motivation variables can be used as a basis for predicting the performance of PT employees. Univar Limawarnane Surabaya. This shows that the hypothesis proposed is supported by the data.
Dampak Gaya Kepemimpinan Dan Lingkungan Kerja Terhadap Kinerja Karyawan PT Prima Beton Bangun Persada Gresik
Authors: Siti Khotimah  , Harsono Teguh  , Rina Dewi  , Achmad Daengs GS  , I Gd Wiyasa
Published: March 2024

In today's increasingly advanced business world, speed and determination are the main keys to the success of every business activity. Therefore, the initial steps for every company are to know quickly and precisely what its employees want and need and what is required. expected by the company. Fulfill or provide employee needs, both in the form of motivation and facilities - facilities which will have a positive impact if they are all in accordance with business activities. Leadership style and work environment influence employee performance. Leadership style and work environment perceived by employees can improve performance or reducing employee performance. Employees who enjoy their work environment will have an impact on increasing the performance of a company, apart from that, the leadership style in the company can make employees feel comfortable, so this will also have an impact on employee performance to produce the best. This research aims to determine the influence of leadership style and work environment on employee performance. This research instrument uses a questionnaire with a total of 30 respondents. The sample taken is employees of PT Prima Beton Bangun Persada Gresik. The research method used is a quantitative method.
Elementary school students' numeracy ability in a socio-cultural context viewed by understanding mathematical concepts
Authors: Chusna Anis Rosiatul , Yustitia Via
Published: March 2024

This research aims to (1) Describe the numeracy of students with high, (2) Describe the numeracy of students with medium, and (3) Describe the numeracy of students with low understanding of mathematical concepts. The selected subjects were 3 out of 29 class 5B students at SDN Rungkut Menanggal II Surabaya. Tests and interviews served as the instrument. The data analysis is data condensation, data presentation, and conclusion. The results of this research are (1) The numeracy of high and medium students' concept understanding; they have been able to apply the formulating process; in the process of using, students are not yet able to determine strategies, are not able to apply concepts, are not able to do calculations; In the interpreting process, students are not yet able to evaluate mathematical results and conclusions. (2) The numeracy of low students' understanding concepts, it was found that students were able to formulate; in the process of using, students can determine strategies, are not yet able to apply concepts, can do calculations; in the process of interpreting students are not yet able to evaluate the results and conclusions of statements.
Binding Affinity, Selectivity, and Pharmacokinetics of the Oxytocin Receptor Antagonist L-368,899 in the Coyote (Canis latrans)
Authors: Freeman Sara M , Catrow J Leon , Cox James Eric , Turano Alexandra , Rich McKenna A , Ihrig Hillary P , Poudyal Naveena , Chang Cheng-Wei Tom , Gese Eric M , Young Julie K , Olsen Aaron L
Published: March 2024

L-368,899 is a selective small-molecule oxytocin receptor (OXTR) antagonist originally developed in the 1990s to prevent preterm labor. Although its utility for that purpose was limited, L-368,899 is now one of the most commonly used drugs in animal research for the selective blockade of neural OXTR after peripheral delivery. A growing number of rodent and primate studies have used L-368,899 to evaluate whether certain behaviors are oxytocin dependent. These studies have improved our understanding of oxytocin’s function in the brains of rodents and monkeys, but very little work has been done in other mammals, and only a single paper in macaques has provided any evidence that L-368,899 can be detected in the CNS after peripheral delivery. The current study sought to extend those findings in a novel species: coyotes (Canis latrans). Coyotes are ubiquitous North American canids that form long-term monogamous pair-bonds. Although monogamy is rare in rodents and primates, all wild canid species studied to date exhibit social monogamy. Coyotes are therefore an excellent model organism for the study of oxytocin and social bonds. Our goal was to determine whether L-368,899 is a viable candidate for future use in behavioral studies in coyotes. We used captive coyotes at the USDA National Wildlife Research Center’s Predator Research Facility to evaluate the pharmacokinetics of L-368,899 in blood and CSF during a 90-min time course after intramuscular injection. We then characterized the binding affinity and selectivity of L-368,899 to coyote OXTR and the structurally similar vasopressin 1a receptor. We found that L-368,899 peaked in CSF at 15 to 30 min after intramuscular injection and slowly accumulated in blood. L-368,899 was 40 times more selective for OXTR than vasopressin 1a receptors and bound to the coyote OXTR with an affinity of 12 nM. These features of L-368,899 support its utility in future studies to probe the oxytocin system of coyotes.
Consistency in Reporting of Loss of Righting Reflex for Assessment of General Anesthesia in Rats and Mice: A Systematic Review
Authors: Teng Michael Z , Merenick Dexter , Jessel Anisha , Ganshorn Heather , Pang Daniel S J
Published: March 2024

General anesthesia induces a reversible loss of consciousness (LOC), a state that is characterized by the inability to feel pain. Identifying LOC in animals poses unique challenges, because the method most commonly used in humans, responding to questions, cannot be used in animals. For over a century, loss of righting reflex (LORR) has been used to assess LOC in animals. This is the only animal method that correlates directly with LOC in humans and has become the standard proxy measure used in research. However, the reporting of how LORR is assessed varies extensively. This systematic literature review examined the consistency and completeness of LORR methods used in rats and mice. The terms ‘righting reflex,’ ‘anesthesia,’ ‘conscious,’ ‘rats,’ ‘mice,’ and their derivatives were used to search 5 electronic databases. The abstracts of the 985 articles identified were screened for indications that the study assessed LORR in mice or rats. Full texts of selected articles were reviewed for LORR methodological completeness, with reported methods categorized by 1) animal placement method, 2) behavioral presence of righting reflex, 3) duration of LORR testing, 4) behavioral LORR, and 5) animal position for testing LORR. Only 22 papers reported on all 5 methodological categories. Of the 22 papers, 21 used unique LORR methodologies, with descriptions of LORR methods differing in at least one category as compared with all other studies. This variability indicates that even papers that included all 5 categories still had substantial differences in their methodological descriptions. These findings reveal substantial inconsistencies in LORR methodology and reporting in the biomedical literature likely compromising study replicability and data interpretation.
Method of encryption in the MST3 cryptosystem based on Automorphisms group of Suzuki's functional field
Authors: Kotukh Y. , Khalimov G. , Korobchinskyi M.
Published: March 2024

This article presents a new implementation of encryption based on MST, focused on generalized Suzuki 2-groups. The well-known MST cryptosystem, based on Suzuki groups, is constructed using a logarithmic signature at the center of the group, leading to a large array of logarithmic signatures. The proposed encryption is based on multi-parameter noncommutative groups, with a focus on the generalized multi-parameter Suzuki 2-group. This approach responds to the progress in the development of quantum computers, which may pose a threat to the security of many open cryptosystems, especially those based on factorization problems and discrete logarithms, such as RSA or ECC. The use of noncommutative groups to create quantum-resistant cryptosystems has been a known approach for the last two decades.

The unsolvable word problem, proposed by Wagner and Magyarik, is used in the field of permutation groups and is key to the development of cryptosystems. Logarithmic signatures, introduced by Magliveras, represent a unique type of factorization suitable for finite groups. The latest version of such an implementation, known as MST3, is based on the Suzuki group. In 2008, Magliveras introduced the LS transitivity limit for the MST3 cryptosystem, and later Swaba proposed an improved version of the cryptosystem, eMST3. In 2018, T. van Trung suggested applying the MST3 approach using strong aperiodic logarithmic signatures for abelian p-groups. Kong and his colleagues conducted a deep analysis of MST3 and noted that due to the absence of publications on the quantum vulnerability of this algorithm, it can be considered a potential candidate for use in the post-quantum era.

The main distinction of the new system is the use of homomorphic encryption to construct logarithmic signature coverings for all group parameters, which improves the secrecy of the cryptosystem, particularly against brute-force attacks.
Analysis of the Availability of Botulinum Toxin Type A in the Treatment of Children with Spastic Cerebral Palsy in Ukraine: A Survey of Doctors
Authors: Auhunas Sabina , Wolf Alex , Kyryk Oksana
Published: March 2024

In Ukraine, about 100,000 children suffer from nervous system disorders, with cerebral palsy (CP) being the leading cause of childhood disability. The European Registry of Children with Cerebral Palsy emphasizes the urgency of this problem.
The objective: to analyze the supply, availability, and use of Botulinum toxin type A for the treatment of spastic cerebral palsy in children in Ukraine.
Materials and methods. The study was conducted from October 2019 to December 2020, and it included monitoring the supply and availability of medicines, collecting quantitative and qualitative data from various sources, and interviewing 64 doctors.
Results. This research highlights disparities in medicine supply satisfaction across Ukraine, with surveys of doctors indicating varying degrees of effectiveness in regions like Kyiv and Kharkiv compared to challenges in Zhytomyr and the Kyiv region. Key issues include surplus medicines, unethical distribution practices, and systemic inefficiencies such as lack of patient registries and insufficient funding. The findings suggest an urgent need for regulatory reforms, enhanced healthcare logistics, and infrastructure improvements to achieve equitable healthcare access nationwide.
Conclusions. This study highlights significant challenges in delivering Botulinum toxin type A for spastic cerebral palsy in Ukraine, including systemic inefficiencies, funding shortages, and procurement delays. It emphasizes the need for policy reforms, improved communication, and digital information access to ensure equitable and efficient healthcare. Urgent improvements are advocated to address these issues and enhance patient care nationwide.
The Contemporary Role of Antinuclear Antibodies in Early Diagnosis of Autoimmune Rheumatic Diseases
Authors: Kozak Natalia , Krasnenkova Tatiana
Published: March 2024

Antinuclear antibodies (ANA) in blood serum remain the primary diagnostic screening test for systemic connective tissue diseases.
This article presents recent literature findings concerning the utilization of ANA in clinical practice. Specifically, it focuses on interpreting analysis positivity, identifying clinically significant types of fluorescence, and categorizing ANA patterns according to specific nosologies. Recommendations for using the name HEp-2-IIF instead of ANA and reporting the results of indirect immunofluorescence analysis for antinuclear antibodies on HEp-2 cell substrates are described in a standardized way, presenting immunofluorescence patterns together with the nomenclature of antibodies and informing about the subsequent management of the patient. Changes made to pattern classification to distinguish between competent and expert level patterns and to improve the visual separation between nuclear and cytoplasmic HEp-2 patterns are discussed.
The need for further study of the prevalence and clinical significance of rare ANA patterns, particularly those directed at the mitotic spindle apparatus (NuMA and MSA-2), is emphasized. Prospects for the study and use of autoantibodies against double-stranded DNA not only in diagnosis but also in the treatment of patients with SLE are noted.
It was concluded that there is a need for further clinical research, collection, and arrangement of various models of HEp-2 IIF to facilitate the accurate determination of «criterion level» patterns, increase the possibilities of early diagnosis of rheumatological diseases, and improve the management tactics of patients in this category.
Rabies Clinical Perspective: Case Description and Care Strategies
Authors: Palii Dmytro , Mohnii Halyna , Voinalovych Olena
Published: March 2024

The information in the article is useful for a wide range of medical professionals, including infectious disease physicians, epidemiologists, traumatologists, family doctors, as well as medical university students.
Rabies is a highly contagious and incurable viral disease that affects the central nervous system that leads to severe encephalitis. This disease is common in 150 countries and territories of the world on all continents except Antarctica. Although the virus can be present in a variety of mammals, the main reservoirs in the wild nature are two specific genera. The most global threat is rabid dogs.
The article analyzes the current situation regarding rabies in Ukraine, with a special emphasis on the Vinnytsia region. By collecting information on the prevalence of rabies cases and analyzing medical records of hospitalized patients, we aim to raise awareness of the severity of the disease and highlight prevention measures.
The clinical case presented in this study is a tool to draw attention to the problem of the spread of rabies. By telling about this case, we hope to inform the society about the frightening consequences of the disease and promote preventive measures.
Solving this issue requires a multifaceted approach. For the effective combat of the rabies spread, it is necessary to review the current restrictions and bans on hunting in the entire territory of Ukraine, in particular in the Vinnytsia region. In addition, more attention should be paid to informing the population through mass media and strengthening the preventive work of medical workers. It is advisable to strengthen control over the vaccination of domestic animals, as this can significantly contribute to the prevention of transmission of the virus. At the same time, it is extremely important to ensure that sufficient quantities of rabies vaccine and immunoglobulin are available for effective treatment and prevention of further cases.
Quality of Life of Patients with Hypertensive Disease and Type 2 Diabetes mellitus and Its Parameters Depending on Plasma Catestatin and Relaxin-2 Levels
Authors: Pankova Olena , Korzh Oleksii
Published: March 2024

The objective: to investigate the impact of hypertensive disease (HD) and concomitant type 2 diabetes mellitus (T2DM) on the quality of life (QOL) of patients using the SF-36 questionnaire and to evaluate the peculiarities of the QOL parameters depending on plasma relaxin-2 (RLN-2) and catestatin (CTS) levels.
Materials and methods. The study was conducted in accordance with the principles of the Declaration of Helsinki. 136 patients took part in the study: 106 patients with HD and 30 healthy volunteers. The patients with HD were divided into two groups. The first group included 55 patients with HD and T2DM, the second group – 51 persons with HD without T2DM.
Each study participant underwent a comprehensive clinical, laboratory and instrumental examinations. All participants filled out quality of life SF-36 questionnaire and the questionary of HD patient. Concentrations of CTS and RLN-2 in blood plasma were determined by enzyme immunoassay method (E4996Hu, BT Lab, Shanghai, China and E-EL-H1582, Elabscience, USA, respectively). All patients filled the home blood pressure monitoring diaries for 31 days.
Statistical data analysis was performed using the SPSS 25.0 statistical program.
Results. The patients with HD had lower parameters of physical and mental components of health compared to healthy volunteers (p<0.005). It was found that the presence of concomitant T2DM leads to even a greater decrease in quality of life indicators than in patients with HD without carbohydrate metabolism disorders (p<0.05). In patients with RLN-2 levels ≥4.69 pg/ml the lower parameters of the physical component of health (p<0.05) and social functioning (p=0.012) were determined. Lower CTS scores are associated with lower QOL scores (p≤0.005). Significant negative correlations were found between average SBP (aSBP) and indicators of physical and mental components of health (p<0.001), while mean DBP had correlations only with general health and total physical component of health (p<0.05).
Conclusions. HD leads to a decreased QOL of patients, which is confirmed by lower scores of the SF-36 questionnaire and established negative correlations between aSBP and QOL parameters. The presence of concomitant T2DM is associated with even a greater decline in physical and mental health components.
DEVELOPMENT OF A GEOGRAPHICAL INFORMATION SYSTEM FOR OPTIMIZING TOURIST ROUTES IN THE ULYTAU NATIONAL NATURAL PARK
Authors:   L.N. Gumilyov Eurasian National University, Tourism Department, Astana, Kazakhstan, SEIDUALIN Darken A. , MUKANOV Aidar H. ,   L.N. Gumilyov Eurasian National University, Tourism Department, Astana, Kazakhstan, AGYBETOVA Rina Y. ,   L.N. Gumilyov Eurasian National University, Tourism Department, Astana, Kazakhstan, MUSSINA Kamshat P. ,   L.N. Gumilyov Eurasian National University, Tourism Department, Astana, Kazakhstan, BERDENOV Zharas G. ,   L.N. Gumilyov Eurasian National University, Faculty of Natural Sciences, Astana, Kazakhs, BABKENOVA Lazzat T. ,   L.N. Gumilyov Eurasian National University, Department of Geodesy and Cartography, Astana, Kazakhstan, ZHENSIKBAYEVA Nazgul Zh. ,   Sarsen Amanzholov East Kazakhstan State University, Department of Ecology and Geography, Ust-Kamenogorsk, Kazakhstan
Published: March 2024

This article analyzes the development of ecotourism in the Ulytau Nature Park using innovative Geographi c information systems technologies. The main purpose of the study is to create a favorable and innovative environment for the development of the tourist experience, including the search and discovery of historical sites, the development of optimal routes and infrastructure improvements. The use of GIS maps in ecological tourism contributes to the development of optimal routes, improvement of tourist infrastructure and provision of informative services. The analysis of the study makes it possible to identify recommendations for public and private organizations in the field of using GIS technologies for the sustainable development of ecotourism. The created GIS map provides information about the park's territory, the location of objects and routes, which contributes to a more informative and oriented tourist experience. The experience of working with GIS technologies enhances the ability of tourists to navigate, discover and obtain information about historical sites and attractions in ecotourism and help enrich the tourist experience.
MAPPALILI CEREMONY IN SUPPORTING UNESCO VERSION OF CULTURAL TOURISM IN MAROS- PANGKEP GEOPARK
Authors:   Department of Geography, Universitas Negeri Malang, Malang, Indonesia, AL HAZAR Badrizal , SUMARMI Sumarmi ,   Department of Geography, Universitas Negeri Malang, Malang, Indonesia, ASTINA I Komang ,   Department of Geography, Universitas Negeri Malang, Malang, Indonesia, SHRESTHA Rajendra Prasad ,   School of Environment, Asian Institute of Technology, Pathum Thani, Thailand
Published: March 2024

Traditional ceremonies are one of the cultural representations that are passed down from generation to generation. The public's interest in traditional ceremonies has declined over time, especially for the younger generation. As part of the MarosPangkep Geopark, it needs special attention by UNESCO's vision and mission. This study aims to: (1). Know the difference of Mappalili Ceremony as cultural tourism in the perspective of Arajang and Balla Kalompoang, (2). know the sustainability of the Mappalili Ceremony in supporting the Maros-Pangkep Geopark according to UNESCO's vision and mission. This research uses qualitative research with an ethnographic approach. Data was collected through in-depth interviews, documentation, and Tudang Sipulung. Data analysis using the Miles and Huberman model, namely: 1). Data collection is done through in-depth interviews and documentation, 2). Data reduction to generalize data from in-depth interviews, 3). Presentation of data to classify the results of interviews and process them, and 4). The Verification is done by pouring and making the final results according to the objectives. The results of the research obtained by the Mappalili Ceremony are a command ceremony to descend the rice fields. The Mappalili Ceremony has the potential to become cultural tourism because in the process there are several unique series of each tribe in managing agricultural land, especially rice fields. The Mappalili Ceremony is cultural tourism that can support the Maros-Pangkep Geopark according to UNESCO's vision and mission. Therefore, efforts to preserve cultural sustainability in the future need to be considered properly to support the development of cultural tourism in South Sulawesi.
Desenvolvimento de aplicativo móvel sobre medicamentos oncológicos veterinários para cães e gatos
Authors: ALMEIDA Karine Silva , MAGALHÃES Viviane Souza , LIMA Tácio Mendonça
Published: March 2024

Objetivo: Desenvolver um aplicativo móvel sobre medicamentos utilizados na oncologia veterinária de cães e gatos. Métodos: Foi realizada uma pesquisa aplicada à produção tecnológica do tipo prototipagem rápida de software para o sistema operacional Android. A estrutura do aplicativo móvel foi desenvolvida em quatro etapas: 1) concepção (avaliação das necessidades, o público-alvo, a pesquisa de literatura e a definição dos conteúdos); 2) planejamento do protótipo (definição dos tópicos e a redação dos módulos, a seleção de mídia e o layout); 3) produção do aplicativo móvel (seleção de ferramentas multimídia, estrutura de navegação e planejamento da configuração do ambiente); e 4) disponibilização do aplicativo móvel. Resultados: Foi possível desenvolver um aplicativo web gratuito (OncoVet Info), em língua portuguesa e com necessidade de conexão à internet. O aplicativo possui dezoito telas, contendo informações sobre 13 medicamentos: asparaginase, carboplatina, ciclofosfamida, cisplatina, clorambucila, dacarbazina, doxorrubicina, ifosfamida, lomustina, metotrexato, mitoxantrona, vimblastina e vincristina. As informações abordam as apresentações  comerciais, indicações, doses e vias de administração, diluente e estabilidade, incompatibilidades, potenciais interações medicamentosas, reações adversas, toxicidade, medidas de biossegurança, risco de extravasamento, aspectos relevantes e a bibliografia. Além disso, o aplicativo conta com informações sobre a equipe, classificação dos riscos de extravasamento, cálculos necessários para realização das condutas terapêuticas, protocolos terapêuticos oncológicos, gerenciamento de resíduos e biossegurança. Conclusão: O OncoVet Info é uma ferramenta que auxilia profissionais envolvidos com o cuidado animal, contribuindo para o uso seguro e responsável de medicamentos oncológicos.
Monogenic free inverse semigroups and partial automorphisms of regular rooted trees
Authors: Kochubinska E. , Oliynyk A.
Published: March 2024

For a one-to-one partial mapping on an infinite set, we present a criterion in terms of its cycle-chain decomposition that the inverse subsemigroup generated by this mapping is monogenic free inverse.

We also give a sufficient condition for a regular rooted tree partial automorphism to extend to a partial automorphism of another regular rooted tree so that the inverse semigroup gene\-ra\-ted by this extended partial automorphism is monogenic free inverse. The extension procedure we develop is then applied to $n$-ary adding machines.
Antibacterial and anticancer activity of green synthesised silver nanoparticles using polysaccharides extracted from the marine alga Portieria hornemannii
Authors: Rose P. Leema , Sarojini V. , Biji G. D
Published: March 2024

The increasing incidence of cancer cases and multi-drug-resistant bacteria, which are major threats to humankind, forces the research world to innovate new molecules to deal with them.  The main aim of the present work is to prepare silver nanoparticles using macroalgal polysaccharides and to study biological activities. The silver nanoparticles (NPs) were prepared using polysaccharides extracted from the marine macro alga Portieria hornemannii by stirring them with 1 mM silver nitrate after 24 h at 90 ºC. The formed silver nanoparticles were characterized using UV-visible spectrophotometry, Fourier transform infrared spectroscopy (FTIR) analysis, Transmission Electron Microscopy (TEM) analysis, selected-area electron diffraction (SAED), and Energy Dispersive X-ray (EDX) analysis. UV-visible spectrum analysis revealed a surface plasmon peak at 380 nm, showing the development of silver nanoparticles. The nanoparticle size varied between 40 and 50 nm and the functional group was analyzed using FT-IR spectrum. The broadband was observed at 3304 cm-1 (hydroxyl and amino group) and the narrow band was observed at 2907 cm-1 (C–H stretching vibration), 1657 cm-1 (stretching of carbonyl groups), and 1001 cm-1 (C–O stretching vibration). The crystalline nature of silver NPs was confirmed by SAED. EDX analysis reveals the purity and the chemical composition of silver NPs. Nanoparticles were highly effective against Proteus mirabilis (24 mm zone of inhibition) and Bacillus substilis (24 mm zone of inhibition). The anticancer activity of the silver nanoparticles tested against colorectal adenocarcinoma cell lines increased at increasing concentrations of nanoparticles.
Food additives and brain complications: A risk to public health
Authors: Jahan Sadaf
Published: March 2024

Food additives comprise the amounts of xenobiotics that are known to affect the physiological metabolic pathways of living tissues. Although organic and inorganic chemicals are considered xenobiotics, organic compounds, the basic chemical entity for most constituents, are reported to be responsible for 80-90% xenobiotics-induced toxicity. Food additives have been the major source of generating these harmful toxins in the human population. Exposure to xenobiotics via dietary habits, environment or medication is inexorable in living creatures. Reports have shown the bidirectional interaction between xenobiotics and biological systems. When ingested, xenobiotics induce physiological, biochemical or pathological changes in the biological system. One study reported that exposure to titanium dioxide nanoparticles can cause cytotoxicity of glial cells and hippocampal neurons, leading to brain damage and changes in hippocampal function, which plays a vital role in the process of memory and learning. Therefore, the complexity and limited plasticity of the brain has always challenged researchers to seek solutions to neuronal and cognitive problems. Including new compounds in the food in the form of pesticides, preservatives, additives, and coloring agents in daily meals is the latest aspect of gene-environment interaction. The sporadic cause of neurodegenerative diseases and its epidemiological distribution can be better understood and countermeasures can be applied only if this relationship is represented quantitatively. Hence, this review focuses on the effect of food additives as xenobiotics, which leads to the potential for a compromised nervous system.
Bacillus cereus-mediated biofermentation of Sardine offal waste: A novel approach to enhance nutritional value by Response Surface Methodology optimization
Authors: Samuel Riya Ann , K. A Paari
Published: March 2024

The rising protein demand in the aquaculture sector has significantly impacted fishmeal supply and pricing. Excessive use of fishmeal can lead to environmental issues and negatively impact marine biodiversity and human food security. Consequently, finding alternative fishmeal in aquaculture is crucial for economic and environmental sustainability. The present study aimed to determine how Bacillus cereus (MT355408) could enhance nutritional value of Sardine fish waste, which could replace fish meal in the market. Solid-state fermentation (SSF) represents a biotechnological method that utilizes microbes to convert discarded fish byproducts into valuable products. The bacterial ability to produce enzymes was studied and optimised for its maximum production to be used as an inoculum for the SSF technique. Different prebiotic sources were also studied for better upliftment of bacteria in the solid-state surface. A single-factor analysis was conducted to investigate the influence of varying prebiotic concentrations, inoculum quantity, and fermentation duration on protein breakdown. After studying the single-factor tests, a further response surface model was employed for better yield. The results indicated that the highest protein yield could be achieved with a fermentation time of 132.893 hours, a prebiotic quantity of 25%, and an inoculum quantity of 5.3%. The study's findings also affirmed that the model was vital in enhancing the crude protein content during fermentation. In conclusion, the model's results contribute valuable insights into fermentation processes, offering practical implications for enhancing protein content and digestibility in similar contexts.
Infarto medular secundario a tratamiento endovascular de aneurisma de aorta toraco-abdominal
Authors: Hernández Villarroel Luis Alfredo , De Lera Alfonso Mercedes
Published: March 2024

Introducción. El infarto medular es una patología severa e infrecuente, que representa el 1% del total de ictus isquémicos, siendo además una complicación rara de distintos procedimientos quirúrgicos. Es causado por la interrupción aguda del flujo sanguíneo de la médula espinal, manifestándose con déficits neurológicos clínicos relacionados con el territorio vascular afectado.

Métodos. Presentamos el caso de un paciente de 80 años, con factores de riesgo cardiovascular, quien presenta en día postquirúrgico 13, tras colocación de endoprótesis vascular por aneurisma toraco-abdominal aparición brusca de paraparesia con progresión a paraplejía e hipoestesia en ambas extremidades inferiores.  Angio-TC de aorta descarta complicación local en la endoprótesis. RM medular mostró imágenes compatibles con Infarto agudo de médula dorsal desde el nivel D9. El paciente no fue subsidiario de tratamiento revascularizador. El tratamiento consistió en medidas de soporte.

Resultados. Al alta el paciente presentaba paraplejia e hipoestesia de ambas extremidades inferiores con incontinencia fecal y urinaria.

Conclusión. El infarto de la médula espinal puede estar limitado a un territorio vascular o estar más extendido según su patogenia. La afectación de la arteria espinal anterior es la más común y se caracteriza por déficits motores bilaterales y pérdida de la sensibilidad termoalgésica, pudiendo llegar a producir un gran impacto en la calidad de vida de los pacientes. Su etiología es variada, incluyéndose la cirugía aórtica dentro de sus causas. La RM es muy útil para su diagnóstico y actualmente no existen guías clínicas para el tratamiento óptimo.
Somnolencia diurna excesiva en adultos mayores de un programa municipal de actividad física
Authors: Avila Ovalle Ivon Johana , Arango Arango Ana Cristina , Cruz Mosquera Freiser Eceomo , Gómez-Barreiro Nathalia Andrea , Márquez-Pérez Yerly Alexandra , Perlaza Claudia Lorena , Lozano Gómez Katherine , Zamora-Vidal Sary , Garzón -Morera Marcela Nayibe
Published: March 2024

Introducción: El ejercicio físico ha demostrado tener un impacto favorable en la salud del individuo. Su combinación con otros estilos de vida saludable, puede impactar de forma positiva diversas áreas entre las que se encuentra la calidad del sueño. Objetivo: Determinar la frecuencia de somnolencia diurna excesiva en adultos mayores de un programa municipal de actividad física de Santiago de Cali, Colombia. Metodología: Estudio de corte trasversal que incluyó 605 adultos mayores de un programa comunitario de la Secretaría de Recreación y Deporte de la Ciudad de Cali, Colombia, durante octubre de 2018 y junio de 2019. Para determinar la presencia de somnolencia diurna excesiva se usó la escala de somnolencia Epworth. Resultados: El 81,5% de la población era de sexo femenino con una edad promedio de 73±8 años. La prevalencia de somnolencia diurna excesiva fue del 10,5%.  Sólo se encontró diferencias significativas en la frecuencia de somnolencia diurna excesiva por estrato socioeconómico, siendo más habitual en el bajo (13% vs 4% P=0,03). Conclusión: La somnolencia diurna excesiva es un fenómeno que afecta los adultos mayores, sin embargo, su frecuencia puede ser menor en aquellos que realizan actividad física.