bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementation of the Principle of the Self-Assessment System For Taxpayers and PPAT in the Validation of E-BPHTB in West Lombok Regency, Indonesia
Authors: Saputri Irma Yulanda , Asmara Galang , Sili Eduardus Bayo
Published: February 2025

This study aims to determine and analyze the application of the principle of self-assessment system and legal protection for third parties from the creation and legal protection for taxpayers and PPAT in the validation process of e-BPHTB in West Lombok Regency. The type of research used is normative empirical, using legislative, conceptual, and sociological approaches. The legal materials/data sources come from primary and secondary data. The analysis used is qualitative. Based on the results of the study, it is known that applying the principle of the self-assessment system in the validation process of e-BPHTB in West Lombok Regency has been running well and can run effectively. Legal protection in the validation process of e-BPHTB in West Lombok Regency for Taxpayers and PPAT includes the right to legal certainty, data confidentiality, objection and appeal mechanisms, and supervision that ensures errors or misuse can be corrected with the correct procedure. In addition, PPAT is also protected in terms of the validity of documents and their responsibilities in making deeds, as long as they act by applicable regulations.
Harnessing AI Tools in Teaching English: Innovations and Implications
Authors: Mirzayeva Aida
Published: February 2025

The advent of Artificial Intelligence (AI) in education has promoted transformative opportunities in language learning. This article explores the integration of AI tools in teaching English as a Second Language (ESL) and English as a Foreign Language (EFL). It focuses on their potential to enhance language acquisition, personalise learning experiences, and address challenges in traditional pedagogical methods. It also evaluates the implications of AI for educators and learners, emphasising ethical considerations and the need for a balanced approach. In this case, the main purpose of using AI in teaching is to support students in the learning process and ensure productivity in language mastery.
Consumer Behaviour in the Gig Economy: Implications for Traditional Labour Market
Authors: Angwaomaodoko Ejuchegahi Anthony
Published: February 2025

The gig economy is fast evolving, typified or characterised by short-term, flexible and task-based digital platforms. This paper investigates how consumer behaviour in the gig economy affects traditional labour markets, focusing on structural shifts in employment and changes in labour market dynamics. It gives an overview of the gig economy, which has experienced rapid growth in transitioning towards flexible, short-term employment arrangements through platforms enabled by digital technologies. The study also highlights the different types of gig platforms, such as ridesharing, freelance marketplaces, and on-demand services, by elaborating on their specific feature and business models. The study reinforces that consumer buying behaviour in the gig economy predicts convenience, cost-effectiveness, and speed of service delivery. The study also indicates that the gig economy has significant implications on the labour market dynamics since new forms of employment challenge regular job security, benefits, and worker rights. These findings support that while the gig economy provides greater flexibility to workers, it also creates more significant issues related to income instability and removing traditional labour protection. The challenges associated with the gig economy are also investigated, including regulatory obstacles, poor or insufficient worker protection, and the long-term viability of gig platforms in light of rising competition. The study concludes that although the gig economy provides new opportunities for consumers and workers, it also involves many challenges that must be thoroughly deliberated and mitigated by policymakers and industry representatives.
The Role of Diversity and Inclusion (D&I) Initiatives in Fostering Global Citizenship Within Higher Education Institutions in West Africa
Authors: Karikari Lovia
Published: February 2025

This study examines the role of diversity and inclusion (D&I) initiatives in fostering global citizenship within higher education institutions in West Africa, with a focus on developing intercultural competence, social responsibility, and critical thinking among students. Recognising global citizenship as a crucial framework for preparing graduates to address complex global challenges, the research uses a qualitative approach, drawing on semi-structured interviews conducted with students, faculty, and administrators at institutions such as the University of Lagos, University of Ghana and Université Cheikh Anta Diop. The interview data, analysed through thematic analysis, reveals that D&I initiatives positively influence students' intercultural understanding and sense of civic duty, equipping them to participate actively in social change. Despite these benefits, the findings highlight barriers, including limited funding, uneven policy implementation, and cultural resistance, which hinder the initiatives' full impact. Additionally, the study incorporates insights from 36 peer-reviewed articles from reputable databases, including ResearchGate and JSTOR, to contextualise D&I's potential for transformative education. The findings suggest that enhanced policy support, resource allocation, and institutional training are vital for maximising D&I programs' role in cultivating globally minded, socially responsible graduates across West African universities.
Experimental Investigation of Green Concrete in Construction Industry by Using Recycled Aggregate
Authors: Pandey Kishan Kumar
Published: February 2025

n this study the natural aggregate replaced by recycled aggregate in different percentages (0%, 20%, 40%, 60%, 80%,
100%). The percentage of recycled aggregate mixed in the definite proportion it improves the property of fresh and hardened
concrete like slump test, compressive strength test up to optimum percentage. From the laboratory test results indicates that the
compressive strength of these mixtures goes on decreasing, however up to the 20% replacement level, it achieves target mean
strength. Hence, for the structural concrete Natural Aggregate can be replaced by the Recycled Aggregate up to 20% range.
Assessing the Role of International Diversification in Enhancing SME Resilience: A Comparative Analysis
Authors: Pandey Anurag
Published: February 2025

Small and Medium Enterprises (SMEs) face increasing financial risks and market volatility, making resilience a
critical factor for their long-term survival and growth. International diversification has been proposed as a strategic tool to
enhance SME resilience by reducing dependency on domestic markets, spreading risks, and accessing new growth opportunities.
This study conducts a comparative analysis of SMEs with varying degrees of international exposure to assess the effectiveness of
diversification in mitigating financial and operational risks. Using a mixed-methods approach, the study examines financial
performance metrics, market adaptability, and risk management strategies of 200 SMEs across multiple industries. Quantitative
data, sourced from financial reports and trade records, were analysed alongside qualitative insights from SME managers
through structured interviews. Results indicate that SMEs with a high level of international diversification exhibit 24% higher
revenue stability and 18% greater profit margin resilience during economic downturns compared to their domestically focused
counterparts. Additionally, these firms demonstrate superior crisis recovery capabilities, with 30% faster operational rebound
post-disruptions. Sectoral differences were observed, with technology-driven and manufacturing SMEs benefiting more
significantly from international expansion, while service-oriented firms faced greater challenges due to regulatory and cultural
barriers. Key challenges identified include resource constraints, trade policy complexities, and market entry barriers, which limit
the effectiveness of diversification for smaller firms. This study provides empirical evidence on the strategic benefits of
international diversification for SMEs, offering practical recommendations for policymakers and business leaders to optimize
international expansion and enhance firm resilience in uncertain economic environments.
Convergence and Quantum Advantage of Trotterized MERA for Strongly-Correlated Systems
Authors: Miao Qiang , Barthel Thomas
Published: February 2025

Strongly-correlated quantum many-body systems are difficult to study and simulate classically. We recently proposed a variational quantum eigensolver (VQE) based on the multiscale entanglement renormalization ansatz (MERA) with tensors constrained to certain Trotter circuits. Here, we determine the scaling of computation costs for various critical spin chains which substantiates a polynomial quantum advantage in comparison to classical MERA simulations based on exact energy gradients or variational Monte Carlo. Algorithmic phase diagrams suggest an even greater separation for higher-dimensional systems. Hence, the Trotterized MERA VQE is a promising route for the efficient investigation of strongly-correlated quantum many-body systems on quantum computers. Furthermore, we show how the convergence can be substantially improved by building up the MERA layer by layer in the initialization stage and by scanning through the phase diagram during optimization. For the Trotter circuits being composed of single-qubit and two-qubit rotations, it is experimentally advantageous to have small rotation angles. We find that the average angle amplitude can be reduced considerably with negligible effect on the energy accuracy. Benchmark simulations suggest that the structure of the Trotter circuits for the TMERA tensors is not decisive; in particular, brick-wall circuits and parallel random-pair circuits yield very similar energy accuracies.
Tintas y trincheras: conflictos, propaganda y construcción de identidades en la historia internacional de los medios de comunicación
Authors: Berdón Prieto Pablo , García Gil Samuel , Herrero Izquierdo Jacobo
Published: February 2025

A lo largo de la historia, los medios de comunicación han desempeñado un papel crucial, no solo como observadores, sino también como actores fundamentales en los momentos decisivos que han marcado al mundo. Al mirar hacia atrás, podemos ver que las trincheras de los enfrentamientos, los debates ideológicos y las transformaciones sociales no solo se encuentran en los campos de batalla, tampoco en las esferas políticas o en los escenarios económicos, sino que también se reflejan en las páginas de los periódicos, las pantallas de la televisión y los dispositivos que usamos a diario. Desde sus formas más rudimentarias hasta las tecnologías más avanzadas, los medios de comunicación han sido espejos y motores de los cambios que han definido épocas enteras.
Este volumen no se enfoca únicamente en cómo las palabras y las imágenes han sido utilizadas para construir realidades. Más bien, ilustra cómo estos medios, en momentos clave, han transformado la manera en que las sociedades perciben y procesan los eventos históricos. No se trata simplemente de documentar el pasado, sino de entender cómo los mensajes transmitidos han influido en el curso de los acontecimientos y en la formación de las estructuras sociales que hoy conocemos.
La obra que tiene en sus manos presenta pues una reflexión profunda sobre cómo la comunicación ha sido una herramienta poderosa en la difusión de ideas. Cada capítulo, elaborado por jóvenes historiadores y expertos en el campo, aborda un caso concreto, desentrañando el modo en que los discursos y las estrategias mediáticas han dado forma a las narrativas históricas, influyendo en la percepción pública y la memoria colectiva. Los autores se sumergen en episodios que van desde los primeros panfletos impresos hasta las campañas mediáticas en redes sociales, analizando el impacto duradero que ese “cuarto poder” determinante ha tenido en las decisiones políticas, las corrientes culturales y las dinámicas sociales.
La presente aportación se aleja también de los enfoques cronológicos convencionales. Por su parte, ofrece una mirada fresca y renovada sobre la historia de la comunicación, en donde los autores han adoptado enfoques innovadores, desafiando las metodologías tradicionales y abriendo nuevos caminos de investigación. En sus páginas, las plataformas informativas son mucho más que vehículos pasivos. Son fuerzas activas que moldean nuestra interpretación de los hechos, redefiniendo el pasado y proyectando sus efectos hacia el futuro. Así, este libro invita al lector a recorrer no solo los caminos trazados por los medios a lo largo de la historia. Propone observarlos como mucho más que simples emisores de información: como arquitectos de realidades, forjadores de imágenes y creadores de escenarios que han moldeado el presente, pero también los horizontes del futuro.
Use of tank mix of herbicide Flex with graminicides: efficiency and safety for soybean
Authors:   Far Eastern Research Institute оf Plant Protection, Morokhovets Tamara V. , Morokhovets Vadim N. ,   Far Eastern Research Institute оf Plant Protection, Shtrebolova Tat’yana V. ,   Far Eastern Research Institute оf Plant Protection, Basay Zoya V. ,   Far Eastern Research Institute оf Plant Protection, Vostrikova Svetlana S. ,   Far Eastern Research Institute оf Plant Protection, Srorik Nina S. ,   Far Eastern Research Institute оf Plant Protection
Published: February 2025

Findings of investigations presented: economic efficiency and safety for the culture (phase
sensitivity) revealed by using tank mixtures Flex 1.5 l/ha + Fusilade Forte 1.5 l/ha and Flex 1.5 l/ha
+ Centurion 0.3 l/ha + Amigo Star 0.6 l/ha in postemergence; the phase of soybean development: two
ternate leaves and the beginning of flowering. The research was conducted as a plot experiment in
the year 2019 at the Far East Research Institute of Plant Protection in accordance with generally
accepted methods on meadow-brown podzolized soils typical for the Primorsky Territory. The experiment showed equally high (decrease in wet above-ground mass by 88-99%) efficiency of these
mixtures in phase of two soybean ternate leaves as well as in early flowering in relation to the combination of annual dicotyledonous and grass weeds during the whole vegetation period of soybean.
Ragweed, that dominates in the cenosis of dicotyledonous weeds, showed high sensitivity (weight
reduction by 99-100%) to both experimental mixtures until the end of the vegetation of the culture.
Tried mixtures also inhibited marsh cress, cockspur, species of bristle grass, hairy cupgrass (Eriochloa
villosa), lamb’s-quarters and southern Acalypha. The toxic effect of mixtures on dicotyledonous perennial species was mainly manifested in inhibiting the growth of the above-ground mass, which in
experimental samples was lower than the control mass by 56-88% when it was taken into account for
the first time after treatment. By the time of harvesting, the herbicidal effect on this group of weeds
was weakened, mainly due to the intensive development of the mass by the curled dock. The high
biological efficiency of tank mixtures and their relative safety for the crop contributed to the increase
in soybean yield. The increase in the seed yield in the experimental versions amounted
to 0.27-0.32 t/ ha, while the yield in the control was 0.87 t / ha. The economic efficiency of using
tank mixtures amounted to 0.37-4.69 thousand rubles/ha.
Comparative assessment of the method of soybean cultivation in the Amur region
Authors:   All-Russian Research Institute of Soya, Nikulchev Konstantin A. , Banetskaya Evgeniya V. ,   All-Russian Research Institute of Soya
Published: February 2025

The article presents the results of studies carried out in order to determine changes in the
agrophysical properties of soil, its microbiological activity and species composition of weeds, depending on the method of soybean cultivation. The studies were carried out by using meadow chernozem-like medium-power soil in the experimental field of the All-Russian Research Institute of
Soybean in a long crop rotation with 40% of soybean saturation, permanent and repeated soybean
crops. Cultivation of soybean in the crop rotation in the end of the growing season resulted in increase,
in 20-cm soil layer, in the moisture content available to plants by 6.0-6.8 mm, general porosity by
2.3-2.9%, decrease in soil density by 0.06-0.08 g/cm3
in comparison with repeated and permanent
soybean crops. During the growing season, the total number of agronomically useful microorganisms in the permanent crops ranged from 7.5 to 31.5 million CFU/1 g of soil, in the crop rotation – from
17.1 to 26.0. In the soil of the crop rotation, the processes of mineralization proceeded more actively
in the phases of the beginning of flowering (mineralization coefficient (Cmin) in the crop rotation –
5.1, in permanent crops – 2.6) and in the phase of ripening of soybeans (Cmin 2.7 and 0.8, respectively), in the remaining phases – at the same level with permanent crops (Cmin 3.7-4.4). The number
of weeds, when soybean was placed in the crop rotation, amounted to 66.7 pcs./m2
, which was 2.2
times less than in permanent crops and 4.6 times less than in repeated crops. Soybean cultivation in
crop rotation contributed to maintaining optimal conditions for the growth and development of crops
and to increase in soybean yield by 0.4 t/ha on average.
Inheritance of economically valuable characters and heterosis in F1 soybean hybrids
Authors:   All-Russian Research Institute of Soya, Fokina Evgenia M. , Titov Sergey A. ,   All-Russian Research Institute of Soya, Gubenko Oksana A. ,   All-Russian Research Institute of Soya
Published: February 2025

The work presents the findings of investigations on the inheritance of the main economically valuable characters inherited by F1 soybean hybrids; the indicators used in the course of the
analysis: indicators of the degree of phenotypic dominance and heterosis. The assessment of 7 soybean hybrid combinations was carried out in respect of productivity presented by 4 quantitative characters: total number of beans, seeds, weight of seeds per plant and weight of 1000 seeds. The research was carried out at the All-Russian Research Institute of Soybean Laboratory of Soybean Breeding
and Genetics in years 2018-2019. In the course of the study of the complex of economically valuable
characters, highly productive varieties and samples of soybean of domestic and foreign selection were
used as parental forms. Crossbreeding combinations were created by using various principles of selection of the initial parental forms. As a result of the research carried out, the nature of inheritance
of the main characters of productivity in intraspecific F1 soybean hybrids was found. The level of
manifestation and magnitude of heterosis varied greatly, depending on the combination of crossing
and the studied character, variation: from the superdominance of high value to depression. At the
same time, there was a tendency for a positive interrelation between the values of heterosis and dominance: the higher the degree of phenotypic dominance, the higher the heterosis. The highest heterosis
effect (24,1...55,2%) was recorded for the main elements of the yield structure (number of beans,
seeds, weight of seeds per one plant) in combinations – ♀ Hei 13-3345-5 (China) x Kyoto (Canada) ,
♀ (L4942 х F1 d.623/86) terminal raceme x ♂ Heihe 4 selection (China), created on the basis of the
principle of ecological and geographical remoteness of the initial parental forms. These hybrid combinations are of the greatest practical interest in breeding research for high productivity in the climates
of the Amur Region.
El criollo limonense: evidencia de su vitalidad dentro y fuera de la provincia de Limón
Authors: Vásquez Carranza Luz Marina
Published: February 2025

En este artículo se analiza la medida en que la lengua criolla limonense se ha mantenido viva por parte de la población afrolimonense tanto en la provincia de Limón como en el Gran Área Metropolitana (GAM), donde muchos han migrado en los últimos 20 años en busca de mejores oportunidades educativas y laborales. El criollo limonense es una lengua minoritaria, la cual se transmite y se mantiene de forma oral. En Limón se usa de forma natural en contextos íntimos como la familia, en actividades religiosas, culturales y entre grupos de amigos, como forma principal de socialización, al lado del español, aunque es utilizada principalmente por personas adultas y adultas mayores, pero no así entre la población joven e infantil, debido a que no ha sido valorada dentro de la misma comunidad afro limonense. En este estudio se reportan las percepciones que tiene la población afrolimonense en Limón sobre esta lengua y se comparan estas percepciones con las que aportan personas afrolimonenses, que han migrado a un nuevo contexto sociocultural donde la lengua dominante es el español. En ambos casos, estas personas manifiestan una gran estima por el criollo limonense, a pesar de su debilitamiento en años recientes y a pesar de que el español es la lengua dominante para la gran mayoría; muestran interés en que se mantenga y se transmita a las generaciones más jóvenes, pues la consideran parte esencial de su identidad y una forma de mantere un vínculo con su herencia afro.
Segregados y disociados: el Gran Tejarcillos y la tragedia de los bienes comunes urbanos
Authors: Coto Murillo Paulo
Published: February 2025

Este artículo es uno de los resultados de una investigación comparativa y cualitativa más amplia, centrada en el estudio de los bienes comunes urbanos y la segregación socioespacial en dos sistemas barriales: el Gran Tejarcillos en Alajuelita y Bello Horizonte en Escazú. Se enfoca en el Gran Tejarcillos, sus barriadas, sus habitantes y cómo enfrentan una serie de problemas tales como la pobreza, la desigualdad social, la economía subterránea del narcotráfico, la estigmatización social y territorial, la violencia social, la desintegración familiar y la desesperanza. En una de las principales conclusiones, los vecinos y sus organizaciones enfrentan estos problemas solos, abandonados por el Estado e instrumentalizados por el mundo político y sus ritmos. El Gran Tejarcillos no solo retrata un caso de tragedia común, sino problemáticas de bien común urbano en la actual sociedad neoliberal costarricense.
La crisis ambiental del sistema capitalista desde las vertientes del pensamiento económico heterodoxo ecológico
Authors: Hartley Ballestero. Rocío
Published: February 2025

El objetivo del artículo es sintetizar los principales aportes de la economía ecológica y el marxismo ecológico, como vertientes del pensamiento económico heterodoxo ecológico, con énfasis en la conceptualización de la relación hombre-naturaleza y la actual crisis ambiental. El vínculo entre crisis ambiental y crisis económica no es circunstancial, puesto que ambas se desarrollan con el surgimiento del capital y la producción capitalista. La situación se ha agravado con la liberalización y la desregulación del capital (globalización). El abordaje de los encadenamientos entre economía y ambiente es difuso y no es realizando una simple abstracción práctica de sus principales sinergias sistémicas como se debe atender tal diversidad. Hoy se requieren análisis más holísticos e integrales, que superen a la economía ambiental.
El itinerario teórico que funda y sostiene la hegemonía del neoliberalismo
Authors: Vargas Solís Luis Paulino
Published: February 2025

Este artículo tiene como objetivo trazar el itinerario teórico que, entre el decenio de 1950 y el decenio de 1970, permitió recomponer la teoría económica neoclásica, dando lugar a una contraofensiva que logró desplazar la ortodoxia del keynesianismo de la síntesis neoclásica, dominante durante los treinta años posteriores a la Segunda Guerra Mundial, para instaurar una nueva ortodoxia: la de un neoclasicismo redivivo. El proceso maduró, gradualmente, a lo largo de aproximadamente veinte años, dando lugar a un aparato teórico sofisticado y dotado de amplia formalización matemática. En este trabajo se busca sintetizar ese proceso y anudar los distintos hilos que moldean una estructura teórica que emergió dominante en el decenio de 1980 y continúa en esa posición hasta la actualidad, aunque sin dejar de experimentar algunos reacomodos de cierta significación. Para entender la hegemonía ideológica y política del neoliberalismo, es indispensable comprender este entramado teórico: de ahí surgen elementos esenciales de su proyecto político e ideológico, y ahí reside su justificación más poderosa.
Clinical and parasitological significance of thelaziosis in dogs and cats
Authors: Hadzi-Milic Milan , Lesevic Andjelka , Krivokuca Petar , Jovanovic Nemanja , Ilic Tamara
Published: February 2025

Thelaziosis is an eye disease of parasitic etiology, caused by nematodes from
the genus Thelazia (Spirurida, Thelaziidae). In addition to domestic animals
(cattle, horses, dogs and cats), the disease also occurs in wild animals,
mammals and birds. Thelazia nematodes have zoonotic potential and can be
transmitted from animals (most often dogs) to humans through the population
of intermediate hosts - fruit flies from the Drosophilidae family. Infection
with the species Thelazia callipaeda has an endemic character, and the
disease mainly occurs Europe in the period from May to October, when the
activity of the intermediate hosts of this nematode is increased. The
presence of these parasites in dogs and cats in Serbia is expected, given
that the climatic conditions in this epizootiological area are identical to
those in the countries where autochthonous cases of thelaziosis have been
reported. The disease is accompanied by increased ocular discharge,
conjunctivitis and keratitis. Diagnosis of thelaziosis can be very simple in
cases of high intensity infections, when the parasites are observed
macroscopically in the dog?s eye. In some cases, allergic or bacterial
conjunctivitis, from which thelaziosis is difficult to distinguish, can
complicate the diagnosis of this parasitosis.
Canagliflozin-induced adaptive metabolism in bone
Authors: Poudel Sher Bahadur , Chlebek Carolyn , Ruff Ryan R. , He Zhiming , Xu Fangxi , Yildirim Gozde , Hu Bin , De Jesus Christopher Lawrence , Shinde Ankita Raja , Nayak Vasudev Vivekanand , Witek Lukasz , Bromage Timothy , Neubert Thomas A , Rosen Clifford J , Yakar Shoshana
Published: February 2025

Sodium-glucose transporter-2 inhibitor (SGLT2i) drugs are widely used for lowering blood glucose levels independent of insulin. Beyond this, these drugs induce various metabolic changes, including weight loss and impaired bone integrity. There is a significant gap in understanding SGLT2i-induced skeletal changes, as SGLT2 is not expressed in osteoblasts or osteocytes, which use glucose to remodel the bone matrix. We studied the impact of 1, 3, or 6 months of canagliflozin (CANA), an SGLT2i treatment, on the skeleton of 6-month-old genetically heterogeneous UM-HET3 mice. Significant metabolic adaptations to CANA were evident as early as 1.5 months post-treatment, specifically in male mice. CANA-treated male mice exhibited notable reductions in body weight and decreased proinflammatory and bone remodeling markers associated with reduced cortical bone remodeling indices. Bone tissue metabolome indicated enrichment in metabolites related to amino acid transport and tryptophan catabolism in CANA-treated male mice. In contrast, CANA-treated female mice showed increases in nucleic acid metabolism. An integrOmics approach of source-matched bone tissue metabolome and bone marrow RNAseq indicated a positive correlation between the two omics data sets in male mice. Three clusters of transcripts and metabolites involved in energy metabolism, oxidative stress response, and cellular proliferation and differentiation were reduced in CANA-treated male mice. In conclusion, CANA affects bone metabolism mainly via the 'glucose restriction state' it induces and impacts bone cell proliferation and differentiation. These findings underline the effects of SGLT2i on bone health and highlight the need to consider sex-specific responses when developing clinical treatments that alter substrate availability.
Understanding the impact of diabetic peripheral neuropathy and neuropathic pain on quality of life and mental health in 6,960 people with diabetes
Authors: Wegeberg Anne-Marie , Nikontovic Amar , Dahl Mørch Carsten , Arendt-Nielsen Lars , Ejskjaer Niels , Brock Christina , Vestergaard Peter , Røikjer Johan
Published: February 2025

Objectives: Diabetic peripheral neuropathy (DPN) and neuropathic pain impacts Quality of Life (QoL) and mental health negatively. This cross-sectional survey study aimed to 1) elucidate the associations between painful and painless DPN and QoL, mental health and socioeconomic factors, 2) assess the prevalence of sensory pain descriptors, and 3) evaluate the association between descriptors and the above factors.

Research Design and Methods: Participants were grouped into people with (n=1,601) and without (n=5,359) DPN based on the Michigan Neuropathy Screening Instrument questionnaire. Participants with DPN were subsequently divided into people with (n=1,085) and without (n=516) concomitant neuropathic pain based on the modified Douleur Neuropathique en 4 Questions-interview.

Results: The study showed diminished QoL (SF36: 55.1 [36.7, 73.6], 82.2 [63.6, 90.9]) and poorer mental health (HADS-A: 5.00 [2, 9], 2.00 [1, 5]. HADS-D: 4.00 [1, 8], 1.00 [0, 3]) in participants with DPN compared to participants without DPN. The addition of pain diminished QoL (SF36: 50.7 [34.8, 69.8]) and mental health (HADS-A: 6 [3, 10], HADS-D: 4 [1, 8]) further.

The most prevalent pain descriptor in participants with painful DPN were burning pain (73%), while the most prevalent sensory descriptor was pins-and-needles (93%). An interesting finding is the high prevalence of itch (44%). Weak associations with mental health and QoL were present for cold pain, electric pain, and itch.

Conclusions: An increased focus on differences in QoL, mental health, and pain phenotypes is of importance to move the field forward towards more interdisciplinary, personalized treatment.
Canagliflozin-induced adaptive metabolism in bone
Authors: Bahadur Poudel Sher , Chlebek Carolyn , R. Ruff Ryan , He Zhiming , Xu Fangxi , Yildirim Gozde , Hu Bin , Lawrence De Jesus Christopher , Raja Shinde Ankita , Vivekanand Nayak Vasudev , Witek Lukasz , Bromage Timothy , A Neubert Thomas , J Rosen Clifford , Yakar Shoshana
Published: February 2025

Sodium-glucose transporter-2 inhibitor (SGLT2i) drugs are widely used for lowering blood glucose levels independent of insulin. Beyond this, these drugs induce various metabolic changes, including weight loss and impaired bone integrity. There is a significant gap in understanding SGLT2i-induced skeletal changes, as SGLT2 is not expressed in osteoblasts or osteocytes, which use glucose to remodel the bone matrix. We studied the impact of 1, 3, or 6 months of canagliflozin (CANA), an SGLT2i treatment, on the skeleton of 6-month-old genetically heterogeneous UM-HET3 mice. Significant metabolic adaptations to CANA were evident as early as 1.5 months post-treatment, specifically in male mice. CANA-treated male mice exhibited notable reductions in body weight and decreased proinflammatory and bone remodeling markers associated with reduced cortical bone remodeling indices. Bone tissue metabolome indicated enrichment in metabolites related to amino acid transport and tryptophan catabolism in CANA-treated male mice. In contrast, CANA-treated female mice showed increases in nucleic acid metabolism. An integrOmics approach of source-matched bone tissue metabolome and bone marrow RNAseq indicated a positive correlation between the two omics data sets in male mice. Three clusters of transcripts and metabolites involved in energy metabolism, oxidative stress response, and cellular proliferation and differentiation were reduced in CANA-treated male mice. In conclusion, CANA affects bone metabolism mainly via the 'glucose restriction state' it induces and impacts bone cell proliferation and differentiation. These findings underline the effects of SGLT2i on bone health and highlight the need to consider sex-specific responses when developing clinical treatments that alter substrate availability.
Comparison of the Effects of SGLT-2i versus GLP-1RA on Cardiovascular and Renal Outcomes in Patients with Type 2 Diabetes Mellitus based on Baseline Renal Function
Authors: Wang Yu , Xia Chao , Li Manna , Xu Gaosi
Published: February 2025

There remained no head-to-head research to evaluate the cardiovascular and renal benefits of sodium-glucose cotransporter 2 inhibitors (SGLT-2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) in patients with type 2 diabetes mellitus (T2DM) at different baseline renal function. We performed a network meta-analysis to compare the two drugs indirectly. Systematic literature searches were conducted on PubMed, Cochrane Library, Web of Science, and Embase, covering their inception until January 7, 2025. Randomized controlled trials (RCTs) comparing the effects of SGLT-2i and GLP-1RA in T2DM with different glomerular filtration rates (eGFR) were selected. Results were reported as Risk ratios (RR) with corresponding 95% confidence intervals (CI). Finally, 10 RCTs involving 87,334 T2DM patients were included. In conclusion, In patients with eGFR > 90 mL/min/1.73m², GLP-1RA exhibited a superior ability to reduce the risk of all-cause death (ACD) compared to SGLT-2i (RR [95% CI]; 0.75 [0.58, 0.97]), but was less effective in reducing the risk of renal outcome (RR [95% CI]; 1.80 [1.15, 2.84]) in patients with eGFR 60-90 mL/min/1.73m². Conversely, in patients with eGFR 30-60 and 60-90 mL/min/1.73m², GLP-1RA did not show an advantage in reducing the risk of hospitalization for heart failure (HHF) (RR [95% CI]; 1.87 [1.15, 3.04] and 1.37 [1.05, 1.78], respectively).
Model Roketlerin Burun Ve Gövde Kısımlarındaki Kompozit Malzemelerin Uçuş Değerlerine Etkisinin Değerlendirilmesi
Authors: Al Abdullah Can , Myderrizi Indrıt
Published: February 2025

Model roket tasarımında kompozit malzeme seçimi uçuş performansı üzerinde güçlü bir etkiye sahiptir. Ayrıca model roket tasarımı için kompozit malzeme seçimine karar verirken, malzemenin maliyetinin yanı sıra performansı da göz önünde bulundurulmalıdır. Havacılık ve model roketçilikte kullanımı en çok tercih edilen PVC, Karbon fiber, Cam elyafı ve Alüminyum gibi kompozit malzemeler, tasarlanan roketin özellikleri ve uçuş değerleri dikkate alınarak simülasyonlarla değerlendirilmiştir. OpenRocket programı ile yapılan simülasyonlarda belirlenen hız, maksimum irtifa, kararlılık, ağırlık oranları, maksimum ivmelenme, uçuş süresi ve iniş hızı kriterlerine göre değerlendirmeler yapılmıştır. Bulgular, alüminyum malzemenin diğer kompozitlere kıyasla model roketin performansını olumsuz etkilediği için elendiğini göstermiştir. En iyi performansı gösteren tüm malzeme kombinasyonları için roketin burun konisi PVC olarak belirlenmiştir. Gövde bölümlerinde kullanılan PVC esaslı kompozitler, roketlerde istenen parametreleri absürt derecede olumlu ve olumsuz şekilde etkilemiştir. Gövde bölümleri için elde edilen değerler birbirine yakın olmasına rağmen, cam elyafın karbon fiberden daha az maliyetli olması onu tasarım için daha uygun hale getirmiştir.
From The Mouth to the Gut: The Oral Microbiome's Role in Promoting Gastrointestinal Disease
Authors: K Houston , ND Alessandro , DA Johnson
Published: February 2025

The traditional thoughts about oral microbial health have centered around the risks for dental caries, gingivitis and periodontal
disease. There has been however ever-increasing data that oral health has significant implications for gastrointestinal health
(GI) with strong evidence links the oral microbiome (which includes bacteria, fungi, virus, archaea), with an ever-increasing
spectrum of metabolic, inflammatory and neoplastic diseases. The oral cavity hosts a diverse range of microorganisms
that form a complex ecosystem known as the oral microbiome. While traditionally associated with pathologic roles in local
conditions like dental caries and periodontal disease, there is growing evidence that disturbances in the oral microbiome can
contribute to systemic inflammation and GI disease development, The risks for causality include direct effects of the dysbiotic
microbiome, as well as inflammatory cytokine upregulation and metabolic byproducts, all of which can have both local and
systemic effects. Altered mucosal integrity can facilitate translocation via systemic spread of these adverse factors directly to
tissues and organs well beyond the oropharynx. Awareness of the role of the oral microbiome role maintaining oral health
should be a new cornerstone of clinical care to potentially prevent, resolve or mitigate a wide array of systemic GI diseases,
including inflammatory bowel disease, colorectal cancer, and metabolic associated inflammatory and fibrotic liver disease.
Bourdieu-Veblen Bias in Chinese Consumer Behaviour and Inequality
Authors:   , Dai Yue
Published: February 2025

This thesis examines culture and its impact on the choice of conspicuous consumption and economic outcomes. Conspicuous consumption was theorized by Veblen (1899) as a means for people to showcase their social distinction and to break social barriers by building their social capital.While regional cultural capital, as conceptualized in Cultural Based Development (CBD), is endogenously acquired by people through the consumption of cultural goods and services, as well as social interactions, it determines the inclinations and prefer-ences of economic choices of people in a locality and thus affects economic outcomes (Tubadji, 2012; 2023). Previous research has shown how culture shapes economic outcomes. Motivated by this research, I argue that cultural capital plays a pivotal role in driving conspicuous consumption, highlighting the significance of how individ-uals navigate through inequality by linking culture and inequality to their economic outcomes. I explore the complexity of the topic by breaking it down into the following questions:•Research Question 1: Is there an impact of cultural friction on the movement of human capital?•Research Question 2: Is there an impact of cultural milieu on the staying human capital?•Research Question 3: The change of cultural milieu on consumer choice.Firstly, I use a panel dataset covering 31 Chinese provinces over 7 years. Cultural heritage and living culture indicators are derived from Principal Component Analysis of 63 regional cultural metrics. Regional interest in conspicuous goods is assessed via internet research data on luxury fashion and jewellery brands, e-cigarettes, and collectible toys. I analyze this relationship using 3SLS estimation with both fixed effects and random effects. Secondly, I derive cultural entropy to explore its rela-tionship with regional innovativeness, measured by the number of patents. Thirdly, I utilize a dataset comprising death tolls during the Chinese Cultural Revolution along-side survey data from the Chinese General Social Survey and employ a difference in difference identification strategy.The main value-added of this work lies in clarifying the two mechanisms through which conspicuous consumption is linked to the outcomes of the economy. To do this, I augment the original CBD framework to show how conspicuous consumption influences human capital accumulation and innovativeness; I offer insights into the role of conspicuous consumption as a tool for accumulating social capital. Additionally, I also contribute to the understanding of the relationship between social mobility, political ideology, and well-being.
Medical Oxygen Service Delivery and Utilization in Ethiopian Healthcare Facilities: Assessment of hospitals in Ethiopia
Authors: Belete Alemayehu Berhanu , Kristinawati Beti
Published: February 2025

Ensuring reliable access to medical oxygen is critical to a quality healthcare system. A descriptive observational study was conducted over 6 months to examine the management and utilization of oxygen in hospitals across Ethiopia, focusing on facility and patient data. The study included 11 hospitals in 6 regions of Ethiopia, with data collection from emergency departments, ICUs, NICUs, pediatric and medical wards. Results showed that 36.36% of facilities had a functioning oxygen system, but less than half had a straightforward person in charge of oxygen and a standardized therapy flow. Meanwhile, 54.55% of facilities reported having medical personnel trained in oxygen therapy, although the number of trained staff varied. Incomplete oxygen prescriptions were shared, such as missing flow rates, SpO2, and monitoring frequency. However, patients who received oxygen therapy had a significantly higher recovery rate (66.23%) compared to patients who did not receive oxygen (21.43%). These findings indicate significant gaps in the availability and management of oxygen infrastructure and suboptimal oxygen administration and monitoring practices. A multifaceted approach is needed to remedy this, including improved functioning of oxygen plants, the appointment of dedicated oxygen attendants, standardized therapy protocols, broader training of medical personnel, and standardization of oxygen funding and costs.
Supply chain management information system project with the use of digital twins
Authors:   Lviv Polytechnic National University, Kunanets Nataliia , Semenchuk Kateryna ,   State University of Intelligent Technologies and Communication, Chernova Liubava ,   Admiral Makarov National University of Shipbuilding
Published: February 2025

The article focuses on the project to develop a supply chain management information system
using a digital twin for the maritime transport chain. Digital twins reflect real objects and
processes in a virtual environment, which enables analysis, modelling and optimisation of supply
chain operations. The author describes the main stages of the project, including requirements
definition, system architecture development, implementation and testing. Particular attention is
paid to the benefits of using digital twins in supply chain management, such as increased
efficiency, reduced risk and improved forecasting. The results of the study show the potential of
digital twins to optimise supply chain management and increase the competitiveness of
companies. The article presents an approach to building a new model of interaction and
systematic optimisation of business processes based on digital technologies at all stages of supply
chain formation, which ensures the creation of a digital twin for the maritime transport chain. In
order to improve supply chains, a digital twin has been proposed, which opens up great prospects
for the management of logistics processes and the exchange of information between supply chain
participants. This paper presents a framework for an integral Digital Supply Chain Twin (DSCT)
capable of covering the entire transport chain. The proposed information system based on the
use of the DSCT provides a number of improvements throughout the supply chain, as well as the
ability to model and evaluate different scenarios for the supply chain. This creates opportunities
to reduce the cost of organising and coordinating transport, improve the quality of transport and
logistics services and make them more reliable by identifying potential problems at an early
stage. The article analyses the main information technologies that facilitate the use of DSCT as a
useful and reliable tool.
Tebus Murah dan Perlindungan Hukum: Tinjauan Hukum Terhadap Hak Konsumen Dalam Transaksi Jual Beli
Authors: Muhtadli Muhtadli , Pelangi Intan , Taufiq M. Shofwan , Pribadi Adhimaz Kondang
Published: February 2025

This study aims to analyze consumer rights and protection in the practice of discounted purchasing (tebus murah) and the perspective of Islamic law regarding such transactions. Discounted purchasing, which is increasingly popular among consumers, offers various benefits but also poses legal risks and challenges. In this context, the study identifies the consumer rights that need to be protected, including the right to clear and accurate information, as well as the right to receive goods that match what was promised. Furthermore, the research explores the legal protections available for consumers in Indonesia based on Law No. 8 of 1999 on Consumer Protection. The research employs a qualitative approach with data collection techniques through interviews, observations, and literature studies. The findings indicate that although there are regulations governing consumer protection, challenges remain in their implementation, especially in the digital context. This study is expected to provide recommendations for improving regulations and better business practices, as well as to enhance consumer awareness regarding their rights in discounted purchasing transactions.
interior das escolas profissionais femininas
Authors: Ferreira Kelen MagrI , Monteiro Ana Maria Reis de Góes
Published: February 2025

Este artigo tem como objetivo relacionar elementos comuns encontrados no interior das scolas Profissionais Femininas que existiram no início do século XX a partir de um importante exemplar que foi a Escola Profissional Feminina de São Paulo, atual Escola Técnica Estadual Carlos de Campos, inaugurada em 1911 no bairro do Brás em São Paulo e que acolheu meninasinteressadas em tornarem-se boas donas de casa e mães. Durante o desenvolvimento da pesquisa sobre a arquitetura dessa escola foi possível levantar objetos e elementos construtivos ainda existentes no interior da edificação que contribuíram e contribuem para o direcionamento pedagógico de tantos cursos profissionais oferecidos. Como parte da metodologia, esses elementos foram fotografados, descritos e situados em planta na antiga Escola Profissional Feminina de São Paulo. Agora eles serão classificados de acordo com suas funções como armazenar, expor, comunicar, enaltecer trabalhos e identificados em outras escolas profissionais femininas do mesmo período, a partir de suas fotografias. O objetivo é estabelecer uma relação comum de uso desses elementos no contexto do modelo de ensino. Os resultados encontrados apontam para uma similaridade na existência de alguns elementos em escolas profissionais femininas congruentes na forma de dispor para que seja possível estabelecer um diálogo entre alunas e o que era necessário ser ensinado.