bluuebunny/crossref_metadata_2025 huggingface dataset:
Danazol mediates collateral sensitivity via STAT3/Myc related pathway in multidrug-resistant cancer cells
Authors: Chang Ying-Tzu , Teng Yu-Ning , Lin Kun-I , Wang Charles C. N. , Morris-Natschke Susan L. , Lee Kuo-Hsiung , Hung Chin-Chuan
Published: August 2019

Multidrug resistance presents an obstacle in cancer treatment. Among numerous combative strategies, collateral sensitivity (CS) drugs have opened a new avenue to defeat cancer by exploiting selective toxicity against multidrug-resistant (MDR) cancer. In the present study, a clinically used synthetic steroid hormone, danazol, was investigated for its CS properties and cytotoxic mechanisms. Compared with natural hormones, danazol possessed a stronger selective cytotoxicity against MDR cancer cells. Danazol induced the arrest of MDR cancer cells at the G2/M phase and caspase-8–related early apoptosis. Furthermore, in MDR cancer cells, danazol reduced STAT3 phosphorylation as well as the expression of STAT3-regulated genes involved in cell survival, such as c-Myc, CDC25, and CDK1. Danazol also upregulated the cell cycle inhibitor p21 in MDR cancer cells. Supporting the experimental results, docking studies have revealed that danazol can likely bind favourably with STAT3. Taken together, our results suggest that danazol exerts a CS effect by inhibiting the STAT3 pathway in MDR cancer cells and thus provides a possible solution for MDR cancers.
Detecting the limits of the biological effects of far-infrared radiation on epithelial cells
Authors: Hsu Yung-Ho , Chen Yu-Wei , Cheng Chung-Yi , Lee San-Liang , Chiu Tzu-Hsuan , Chen Cheng-Hsien
Published: August 2019

Far-infrared radiation (FIR) exerts numerous beneficial effects on health and cell physiology. Recent studies revealed that the biological effects of FIR are independent of thermal effects. There is no proper method for measuring the parameters of the non-thermal biological effects of FIR, which limits its biomedical application. In this study, we established a cell detection platform using epithelial cell migration to measure the limits of the biological effects of FIR. FIR promoted the migration of rat renal tubular epithelial cells as revealed by our standardized detection method. We defined the ratio of the FIR-promoted migration area to the migration area of the control group as the FIR biological index (FBI). An increase of the FBI was highly associated with FIR-promoted mitochondrial function. Through FBI detection, we revealed the limits of the biological effects of FIR, including effective irradiation time, wavelengths, and temperature. FBI detection can be used to clarify important parameters of the biological effects of FIR in biomedical studies and health industry applications.
A universal approach to investigate circRNA protein coding function
Authors: Mo Dingding , Li Xinping , Raabe Carsten A. , Cui Di , Vollmar Jeanne-Franca , Rozhdestvensky Timofey S. , Skryabin Boris V. , Brosius Juergen
Published: August 2019

Circular RNAs (circRNAs) are an emerging class of RNA molecules that have been linked to human diseases and important regulatory pathways. Their functional roles are still under investigation, often hampered by inefficient circRNA formation in and ex vivo. We generated an intron-mediated enhancement (IME) system that—in comparison to previously published methods—increases circRNA formation up to 5-fold. This strategy also revealed previously undetected translation of circRNA, e.g., circRtn4. Substantiated by Western blots and mass spectrometry we showed that in mammalian cells, translation of circRtn4 containing a potential “infinite” circular reading frame resulted in “monomers” and extended proteins, presumably “multimer” tandem repeats. In order to achieve high levels of circRNA formation and translation of other natural or recombinant circRNAs, we constructed a versatile circRNA expression vector—pCircRNA-DMo. We demonstrated the general applicability of this method by efficiently generating two additional circRNAs exhibiting high expression levels. The circRNA expression vector will be an important tool to investigate different aspects of circRNA biogenesis and to gain insights into mechanisms of circular RNA translation.
Construction of a high density linkage map and genome dissection of bruchid resistance in zombi pea (Vigna vexillata (L.) A. Rich)
Authors: Amkul Kitiya , Wang Lixia , Somta Prakit , Wang Suhua , Cheng Xuzhen
Published: August 2019

Zombi pea (Vigna vexillata) is a legume crop that is resistant to several biotic and abiotic stresses. Callosobruchus maculatus and Callosobruchus chinensis are serious stored-insect pests of legume crops. We constructed a high-density linkage map and performed quantitative trait loci (QTLs) mapping for resistance to these insect species in zombi pea. An F2 population of 198 individuals from a cross between ‘TVNu 240’ (resistant) and ‘TVNu 1623’ (susceptible) varieties was used to construct a linkage map of 6,529 single nucleotide polymorphism markers generated from sequencing amplified fragments of specific loci. The map comprised 11 linkage groups, spanning 1,740.9 cM, with an average of 593.5 markers per linkage group and an average distance of 0.27 cM between markers. High levels of micro-synteny between V. vexillata and cowpea (Vigna unguiculata), mungbean (Vigna radiata), azuki bean (Vigna angularis) and common bean (Phaseolus vulgaris) were found. One major and three minor QTLs for C. chinensis resistance and one major and one minor QTLs for C. maculatus resistance were identified. The major QTLs for resistance to C. chinensis and C. maculatus appeared to be the same locus. The linkage map developed in this study will facilitate the identification of useful genes/QTLs in zombi pea.
Susceptibility survey of Ommatissus lybicus (de Bergevin) populations against deltamethrin and fenitrothion in Oman
Authors: Khan Rashad Rasool , Al-Khatri Salim Ali Humaid , Al-Ghafri Thuwaini Hashil Abdullah , Al-Mazidi Ibtisam Salim Suliman , Al-Rawahi Fatima Gharib , Al-Jabri Saif Suliman , Hussain Muhammad Hammad
Published: August 2019

Despite of extensive application of insecticides, severe infestation of date palms is reported with Ommatissus lybicus every year. The development of insecticide resistance in the field strains receiving heavy pesticide regimes can be a reason for unsuccessful control. Seventeen field strains of O. lybicus from Oman were appraised for resistance against deltamethrin and fenitrothion in years 2017 and 2018. Eleven field strains depicted susceptibility (RR < 3-fold) while six strains expressed minor (RR = 3–5-fold) to low level (RR = 5–10-fold) of resistance against deltamethrin when compared with lab-susceptible strain. In case of fenitrothion, fourteen field strains exhibited minor to low level of resistance and only two showed susceptibility. Intermediate resistance (RR = 10–40-fold) was also reported in one field strain against fenitrothion. A significant but low resistance (RR = 7.86-fold) was observed in a lab strain selected with deltamethrin for resistance development mechanism studies. The deltamethrin-selected strain exhibited minor resistance development (RR = 3.13-fold) against fenitrothion. Significant reduction in resistance was observed with higher toxicity values when the two pesticides were tested along with piperonyl butoxide (PBO) against all the field collected dubas bug strains. Higher susceptibility of field strains to deltamethrin suggest it a suitable alternate candidate to deter resistance development in O. lybicus.
Microbiota-derived Trimethylamine N-oxide Predicts Cardiovascular Risk After STEMI
Authors: Matsuzawa Yasushi , Nakahashi Hidefumi , Konishi Masaaki , Sato Ryosuke , Kawashima Chika , Kikuchi Shinnosuke , Akiyama Eiichi , Iwahashi Noriaki , Maejima Nobuhiko , Okada Kozo , Ebina Toshiaki , Hibi Kiyoshi , Kosuge Masami , Ishigami Tomoaki , Tamura Kouichi , Kimura Kazuo
Published: August 2019

Trimethylamine N-oxide (TMAO), a metabolite derived from the gut microbiota, is proatherogenic and associated with cardiovascular events. However, the change in TMAO with secondary prevention therapies for ST-segment elevation acute myocardial infarction (STEMI) remains unclear. The purpose of this study was to investigate the sequential change in TMAO levels in response to the current secondary prevention therapies in patients with STEMI and the clinical impact of TMAO levels on cardiovascular events We included 112 STEMI patients and measured plasma TMAO levels at the onset of STEMI and 10 months later (chronic phase). After the chronic-phase assessment, patients were followed up for cardiovascular events. Plasma TMAO levels significantly increased from the acute phase to the chronic phase of STEMI (median: 5.63 to 6.76 μM, P = 0.048). During a median period of 5.4 years, 17 patients experienced events. The chronic-phase TMAO level independently predicted future cardiovascular events (adjusted hazard ratio for 0.1 increase in log chronic-phase TMAO level: 1.343, 95% confidence interval 1.122–1.636, P = 0.001), but the acute-phase TMAO level did not. This study demonstrated the clinical importance of the chronic-phase TMAO levels on future cardiovascular events in patients after STEMI.
Myeloid maturation potentiates STAT3-mediated atypical IFN-γ signaling and upregulation of PD-1 ligands in AML and MDS
Authors: Yoyen-Ermis Digdem , Tunali Gurcan , Tavukcuoglu Ece , Horzum Utku , Ozkazanc Didem , Sutlu Tolga , Buyukasik Yahya , Esendagli Gunes
Published: August 2019

Interferon (IFN)-γ is the major mediator of anti-tumor immune responses; nevertheless, cancer cells use intrigue strategies to alter IFN-γ signaling and avoid elimination. Understanding the immune regulatory mechanisms employed by acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) cells upon exposure to IFN-γ is critical for development of immunotherapy and checkpoint blockade therapy approaches. This study aims to explore the influence of myeloid maturation on IFN-γ-induced PD-L1 and PD-L2 expression and on pro-leukemogenic transcription factor STAT3 signaling in AML and MDS. Stimulation of myeloid blasts’ maturation by all-trans retinoic acid (ATRA) or 1α,25-dihydroxyvitamin D3 (vitamin D) increased the CD11b+ fraction that expressed PD-1 ligands in response to IFN-γ. Intriguingly, STAT3 pathway was potently induced by IFN-γ and strengthened upon prolonged exposure. Nonetheless, STAT3-mediated atypical IFN-γ signaling appeared as a negligible factor for PD-L1 and PD-L2 expression. These negative influences of IFN-γ could be alleviated by a small-molecule inhibitor of STAT3, stattic, which also inhibited the upregulation of PD-L1. In conclusion, induction of myeloid maturation enhances the responsiveness of AML and MDS cells to IFN-γ. However, these malignant myeloid cells can exploit both STAT3 pathway and PD-1 ligands to survive IFN-γ-mediated immunity and maintain secondary immune resistance.
Development of Gabapentin Expandable Gastroretentive Controlled Drug Delivery System
Authors: Rimawi Issam B. , Muqedi Ramzi H. , Kanaze Feras I.
Published: August 2019

Expandable drug delivery systems are one of many gastroretentive delivery systems which have emerged during the last few years. Expandable systems are usually folded in a capsule and expand to dimensions greater than the pyloric sphincter upon contact with gastric fluid. This prevents them from being evacuated by gastric emptying. The main objective of developing such systems is to increase the residence time of a specific drug in stomach; controlling its release, increasing its bioavailability and decreasing its side effects and dosing frequency. An expandable gastroretentive drug delivery system containing Gabapentin was developed using experimental design (D-optimal reduced quadratic design). This system was able to unfold at stomach pH in less than 15 minutes and obtain a controlled release of 78.1 ± 4.7% in 6 hours following zero-order release kinetic model. It is rigid in stomach and its rigidity decreases at intestinal pH. FTIR analysis indicated the occurrence of hydrogen bonding in Gabapentin when present in the developed system, which might be responsible for the drug’s controlled release. XRD analysis indicated that Gabapentin physical properties changed from crystalline in the typical state to amorphous in the developed system.
Link clustering explains non-central and contextually essential genes in protein interaction networks
Authors: Kim Inhae , Lee Heetak , Lee Kwanghwan , Han Seong Kyu , Kim Donghyo , Kim Sanguk
Published: August 2019

Recent studies have shown that many essential genes (EGs) change their essentiality across various contexts. Finding contextual EGs in pathogenic conditions may facilitate the identification of therapeutic targets. We propose link clustering as an indicator of contextual EGs that are non-central in protein-protein interaction (PPI) networks. In various human and yeast PPI networks, we found that 29–47% of EGs were better characterized by link clustering than by centrality. Importantly, non-central EGs were prone to change their essentiality across different human cell lines and between species. Compared with central EGs and non-EGs, non-central EGs had intermediate levels of expression and evolutionary conservation. In addition, non-central EGs exhibited a significant impact on communities at lower hierarchical levels, suggesting that link clustering is associated with contextual essentiality, as it depicts locally important nodes in network structures.
Atorvastatin increases the production of proinflammatory cytokines and decreases the survival of Escherichia coli-infected mice
Authors: Hussein Hadi M. , Al-Khoury Diva Kalash , Abdelnoor Alexander M. , Rahal Elias A.
Published: August 2019

To assess whether the immunosuppressive effects of atorvastatin outweigh its antibacterial ones in an infection, mice were infected with Escherichia coli and administered atorvastatin; survival rates were then monitored. Mice treated with atorvastatin post-infection showed a remarkable decrease in their survival rate. On the other hand, the higher the level of serum IFN-γ in the infected mice treated with atorvastatin, the lower was the survival rate. Levels of IL-4 were markedly depressed in all groups infected with E. coli and treated with atorvastatin. Since atorvastatin inhibits IFN-γ expression in the absence of bacterial infection, we examined whether bacterial lipopolysaccharide (LPS) was the element capable of overriding this inhibition. Mouse peripheral blood mononuclear cells were treated with atorvastatin and lipopolysaccharide ex vivo then proinflammatory (IFN-γ, TNFα, IL-6) and prohumoral/regulatory (IL-4, IL-13, IL-10) cytokine levels were analyzed in culture supernatants. While proinflammatory cytokine levels were decreased upon treatment with atorvastatin alone, their levels were markedly elevated by treatment with LPS, bacterial lysate or bacterial culture supernatant. On the other hand, atorvastatin exerted an inhibitory effect on production of the prohumoral/regulatory cytokines. Our data indicates that any consideration for statins as antimicrobial treatment should assess the possible adverse outcomes.
A novel Carcinoembryonic Antigen (CEA)-Targeted Trimeric Immunotoxin shows significantly enhanced Antitumor Activity in Human Colorectal Cancer Xenografts
Authors: Lázaro-Gorines R. , Ruiz-de-la-Herrán J. , Navarro R. , Sanz L. , Álvarez-Vallina L. , Martínez-del-Pozo A. , Gavilanes J. G. , Lacadena J.
Published: August 2019

Immunotoxins are chimeric molecules, which combine antibody specificity to recognize and bind with high-affinity tumor-associated antigens (TAA) with the potency of the enzymatic activity of a toxin, in order to induce the death of target cells. Current immunotoxins present some limitations for cancer therapy, driving the need to develop new prototypes with optimized properties. Herein we describe the production, purification and characterization of two new immunotoxins based on the gene fusion of the anti-carcinoembryonic antigen (CEA) single-chain variable fragment (scFv) antibody MFE23 to α-sarcin, a potent fungal ribotoxin. One construct corresponds to a conventional monomeric single-chain immunotoxin design (IMTXCEAαS), while the other one takes advantage of the trimerbody technology and exhibits a novel trimeric format (IMTXTRICEAαS) with enhanced properties compared with their monomeric counterparts, including size, functional affinity and biodistribution, which endow them with an improved tumor targeting capacity. Our results show the highly specific cytotoxic activity of both immunotoxins in vitro, which was enhanced in the trimeric format compared to the monomeric version. Moreover, the trimeric immunotoxin also exhibited superior antitumor activity in vivo in mice bearing human colorectal cancer xenografts. Therefore, trimeric immunotoxins represent a further step in the development of next-generation therapeutic immunotoxins.
Coherent quantum dynamics of systems with coupling-induced creation pathways
Authors: Rogers Steven D. , Graf Austin , Javid Usman A. , Lin Qiang
Published: August 2019

Many technologies emerging from quantum information science heavily rely upon the generation and manipulation of entangled quantum states. Here, we propose and demonstrate a new class of quantum interference phenomena that arise when states are created in and coherently converted between the propagating modes of an optical microcavity. The modal coupling introduces several new creation pathways to a nonlinear optical process within the device, which quantum mechanically interfere to drive the system between states in the time domain. The coherent conversion entangles the generated biphotons between propagation pathways, leading to cyclically evolving path-entanglement and the manifestation of coherent oscillations in second-order temporal correlations. Furthermore, the rich device physics is harnessed to tune properties of the quantum states. In particular, we show that the strength of interference between pathways can be coherently controlled, allowing for manipulation of the degree of entanglement, which can even be entirely quenched. The states can likewise be made to flip-flop between exhibiting initially correlated or uncorrelated behavior. The phenomena presented here open a route to creating higher dimensional entanglement and exotic multi-photon states.
Hypervalent iodine initiated intramolecular alkene dimerisation: a stereodivergent entry to cyclobutanes
Authors: Zhu Yuxiang , Colomer Ignacio , Donohoe Timothy J.
Published: August 2019

Access to all-trans and trans–cis–trans cyclobutane diastereoisomers; the tether X can be cleaved.
Photoinduced synthesis of fluorinated dibenz[b,e]azepines via radical triggered cyclization
Authors: Qi Xu-Kuan , Zhang Hong , Pan Zi-Tong , Liang Rong-Bin , Zhu Can-Ming , Li Jing-Hong , Tong Qing-Xiao , Gao Xue-Wang , Wu Li-Zhu , Zhong Jian-Ji
Published: August 2019

A simple, mild and efficient approach to access fluorinated dibenz[b,e]azepines via visible-light photoredox catalysis is presented.
Interfacial self-assembly of gold nanoparticle-polymer nanoconjugates into microcapsules with near-infrared light modulated biphasic catalysis efficiency
Authors: Su Jiaojiao , Wang Shengliang , Xu Zhijun , Wu Guangyu , Wang Lei , Huang Xin
Published: August 2019

Gold nanoparticle-based microcapsules based on the interfacial assembly significantly enhanced the biphasic catalytic reaction rate upon near-infrared light irradiation.
Laplacian free and asymptotic corrected semilocal exchange potential applied to the band gap of solids
Authors: Patra Abhilash , Jana Subrata , Myneni Hemanadhan , Samal Prasanjit
Published: August 2019

Improved band gap of n-type semiconductor ZrS2 within semi-local density functional theory is shown. The band gap of mBR-TBMBJ agrees well with the hybrid HSE06 functional.
Reversible uptake of sulfur-containing gases by single crystals of a Cr8 metallacrown
Authors: Vitórica-Yrezábal Iñigo J. , Sava Daniel Florin , Reta Daniel , Timco Grigore A. , Winpenny Richard E. P.
Published: August 2019

The exposure of green crystals of the [CrF(O2CtBu)2]8Cr8 metallacrown to SO2 and H2S gases results in the binding of the gas molecules in the internal molecular cavity, despite the absence of any pores or channels in the structure.
Stabilization of different redox levels of a tridentate benzoxazole amidophenoxide ligand when bound to Co(iii) or V(v)
Authors: Safaei Elham , Balaghi S. Esmael , Chiang Linus , Clarke Ryan M. , Martelino Diego , Webb Michael I. , Wong Edwin W. Y. , Savard Didier , Walsby Charles J. , Storr Tim
Published: August 2019

The electronic structure of Co and V complexes of a tridentate benzoxazole-containing aminophenol ligandNNOH2were characterized by both experimental and theoretical methods.
Structural, phonon, magnetic and optical properties of novel perovskite-like frameworks of TriBuMe[M(dca)3] (TriBuMe = tributylmethylammonium; dca = dicyanamide; M = Mn2+, Fe2+, Co2+, Ni2+)
Authors: Mączka Mirosław , Gągor Anna , Ptak Maciej , Stefańska Dagmara , Macalik Lucyna , Pikul Adam , Sieradzki Adam
Published: August 2019

Tributylmethylammonium metal dicyanamides exhibit huge caloric effects due to order–disorder phase transitions, and the Mn analogue shows orange emission under 420 nm excitation.
I2 vapor-induced degradation of formamidinium lead iodide based perovskite solar cells under heat–light soaking conditions
Authors: Fu Fan , Pisoni Stefano , Jeangros Quentin , Sastre-Pellicer Jordi , Kawecki Maciej , Paracchino Adriana , Moser Thierry , Werner Jérémie , Andres Christian , Duchêne Léo , Fiala Peter , Rawlence Michael , Nicolay Sylvain , Ballif Christophe , Tiwari Ayodhya N. , Buecheler Stephan
Published: August 2019

We reveal an iodine vapor-induced degradation mechanism in formamidinium–lead-iodide-based perovskite solar cells stressed under combined heat and light illumination.
Plasma-induced covalent immobilization and patterning of bioactive species in microfluidic devices
Authors: Shakeri Amid , Imani Sara M. , Chen Eric , Yousefi Hanie , Shabbir Raed , Didar Tohid F.
Published: August 2019

Here, we present a straightforward technique to create bio-functional microfluidic channels using CO2 plasma to induce both carboxylic and hydroxyl groups onto the channel surface.
Targeted metabolomics approach for identification of relapsing–remitting multiple sclerosis markers and evaluation of diagnostic models
Authors: Kasakin Marat F. , Rogachev Artem D. , Predtechenskaya Elena V. , Zaigraev Vladimir J. , Koval Vladimir V. , Pokrovsky Andrey G.
Published: August 2019

Relapsing–remitting multiple sclerosis markers determined (a) and multivariate models for early diagnosis were evaluated (b).
All-solution processed inverted green quantum dot light-emitting diodes with concurrent high efficiency and long lifetime
Authors: Yang Zhiwen , Wu Qianqian , Lin Gongli , Zhou Xiaochuan , Wu Weijie , Yang Xuyong , Zhang Jianhua , Li Wanwan
Published: August 2019

An all-solution processed inverted green quantum dot-based light-emitting diode with concurrent high efficiency and long lifetime is obtained by precisely controlled double shell growth of quantum dots.
Enhanced chemiresistive sensing performance of well-defined porous CuO-doped ZnO nanobelts toward VOCs
Authors: Li Gang , Su Yao , Chen Xu-Xiu , Chen Li , Li Yong-Yu , Guo Zheng
Published: August 2019

Due to the synergic effect between the electron depletion layer and the local hole accumulation layer at the p–n junctions of CuO|ZnO heterointerfaces, well-defined porous CuO-doped ZnO nanobelts exhibit an excellent sensing performance toward VOCs.
Nitrogen-doped fluorescent graphene nanosheets as visible-light-driven photocatalysts for dye degradation and selective sensing of ascorbic acid
Authors: Das Gouri Sankar , Tripathi Kumud Malika , Kumar Gautam , Paul Sudip , Mehara Surbhi , Bhowmik Soumalya , Pakhira Bholanath , Sarkar Sabyasachi , Roy Manas , Kim TaeYoung
Published: August 2019

Facile synthesis of water soluble fluorescent N-doped graphene nanosheets for multifunctional applications in photocatalysis and sensing.
Electrocatalytic determination of Cd2+ and Pb2+ using an l-cysteine tungstophosphate self-assembled monolayer on a polycrystalline gold electrode
Authors: Dianat Somayeh , Hatefi-Mehrjardi Abdolhamid , Mahmoodzadeh Kourosh , Kakhki Somayeh
Published: August 2019

Constructing a sensitive electrochemical sensor based on (Cys)PW for Cd2+ and Pb2+ detection at the nanomolar level with remarkable selectivity.
Controlled nanofabrication of metal-free SERS substrate on few layered black phosphorus by low power focused laser irradiation
Authors: Kundu Anirban , Rani Renu , Hazra Kiran Shankar
Published: August 2019

Nanostructured BP flake shows inherent capability of SERS response and can be considered as a replacement of metal nanoparticle based SERS substrate.
Stretchable/flexible silver nanowire electrodes for energy device applications
Authors: Jung Jinwook , Cho Hyunmin , Yuksel Recep , Kim Dongkwan , Lee Habeom , Kwon Jinhyeong , Lee Phillip , Yeo Junyeob , Hong Sukjoon , Unalan Husnu Emrah , Han Seungyong , Ko Seung Hwan
Published: August 2019

This review focuses on the silver nanowires (Ag NWs) based stretchable and flexible energy devices for self-sustainable devices.
Imaging dopant distribution across complete phase transformation by TEM and upconversion emission
Authors: Avram Daniel , Colbea Claudiu , Florea Mihaela , Lazar Sorin , Stroppa Daniel , Tiseanu Carmen
Published: August 2019

Correlating dopant distribution to its optical response represents a complex challenge for nanomaterials science.
Two-dimensional Nb2O5 holey nanosheets prepared by a graphene sacrificial template method for high performance Mg2+/Li+ hybrid ion batteries
Authors: Huang Huihuang , Zhao Guangyu , Zhang Naiqing , Sun Kening
Published: August 2019

Two-dimensional Nb2O5 holey nanosheets with outstanding rate performance and cycling performance as the cathode of novel Mg2+/Li+ hybrid ion batteries.
Phonon transport across crystal-phase interfaces and twin boundaries in semiconducting nanowires
Authors: Carrete Jesús , López-Suárez Miquel , Raya-Moreno Martí , Bochkarev Anton S. , Royo Miquel , Madsen Georg K. H. , Cartoixà Xavier , Mingo Natalio , Rurali Riccardo
Published: August 2019

We combine state-of-the-art Green's-function methods and nonequilibrium molecular dynamics calculations to study phonon transport across the unconventional interfaces that make up crystal-phase and twinning superlattices in nanowires.
Guanidine as inexpensive dual function ligand and reducing agent for ATRP of methacrylates
Authors: Santos Madson R. E. , Ferreira Sílvia M. , Mendonça Patrícia V. , De Bon Francesco , Serra Armenio C. , Coelho Jorge F. J.
Published: August 2019

N,N,N′,N′-Tetramethyl guanidine, an inexpensive and commercially available organic base, is used for the first time as ligand without any chemical modification for the supplemental activator and reducing agent atom transfer radical polymerization.
Synthesis of telechelic polyesters by means of transesterification of an A2 + B2 polycondensation-derived cyclic polyester with a functionalized diester
Authors: Okabayashi Ryouichi , Ohta Yoshihiro , Yokozawa Tsutomu
Published: August 2019

End-functionalized linear polyesters were synthesized by means of base-catalyzed transesterification of a cyclic polyester, obtained by A2 + B2 polycondensation, with a symmetric functional diester as an exchange reagent.
Redox-switchable olefin cross metathesis (CM) reactions and acyclic diene metathesis (ADMET) polymerizations
Authors: Ryu Yeonkyeong , Shao Huiling , Ahumada Guillermo , Liu Peng , Bielawski Christopher W.
Published: August 2019

We show that redox-switchable catalysis may be used to control acyclic diene metathesis (ADMET) polymerizations and related cross metathesis (CM) reactions.
Access to 2-substituted 1-pyridin-3-yl-β-carboline derivatives by intramolecular radical cyclization-ring opening-SNAr substitution
Authors: Recio Javier , Pérez-Redondo Adrián , Alvarez-Builla Julio , Burgos Carolina
Published: August 2019

A new method for the synthesis of 1-pyridin-3-yl-β-carboline derivatives involving an intramolecular radical reaction and SNAr substitution, is described.
Cell changes and differential proteomic analysis during biodegradation of decabromodiphenyl ether (BDE-209) byPseudomonas aeruginosa
Authors: Liu Yu , Liu Zhe , Gong Aijun , Qiu Lina , Zhang Weiwei , Li Jingrui , Li Fukai , Bai Yuzhen , Li Jiandi , Gao Ge
Published: August 2019

BDE-209 is a persistent organic pollutant. To promote microbial biodegradation of BDE-209 and gain further insight into its mechanism, cell changes and differential proteomic analysis ofP. aeruginosaduring biodegradation were studied.
Electrochemical analysis of Na–Ni bimetallic phosphate electrodes for supercapacitor applications
Authors: Mirghni Abdulmajid A. , Oyedotun Kabir O. , Olaniyan O. , Mahmoud Badr A. , Sylla Ndeye Fatou , Manyala Ncholu
Published: August 2019

CV curve of the hybrid device as reflection of the conductive NaNi4(PO4)3/GF composite and AC.
Controllable synthesis of CsPbI3 nanorods with tunable photoluminescence emission
Authors: Wen Zhikai , Zhai Wei , Liu Chang , Lin Jing , Yu Chao , Huang Yang , Zhang Jun , Tang Chengchun
Published: August 2019

Ultrafine CsPbI3 nanorods with tunable narrow photoluminescence emission are directly synthesized by solvothermal method.
Application of ANN modeling techniques in the prediction of the diameter of PCL/gelatin nanofibers in environmental and medical studies
Authors: Kalantary Saba , Jahani Ali , Pourbabaki Reza , Beigzadeh Zahra
Published: August 2019

A new tool for prediction the diameter of nanofibers is presented: the use of adaptive modeling techniques to predict fiber diameter and study the impact of electrospinning process parameters on electrospinning fiber diameter.
Structured crystallization for efficient all-inorganic perovskite solar cells with high phase stability
Authors: Wang Zhen , Baranwal Ajay K. , Kamarudin Muhammad Akmal , Kamata Yusuke , Ng Chi Huey , Pandey Manish , Ma Tingli , Hayase Shuzi
Published: August 2019

Yttrium incorporation enhanced the performance of CsPbI2Br perovskite solar cells and the phase stability was improved significantly.
Effect of magnesium particle fraction on osteoinduction of hydroxyapatite sphere-based scaffolds
Authors: Xu Taotao , He Xu , Chen Zhenghui , He Lei , Lu Mengjie , Ge Jianhua , Weng Jie , Mu Yandong , Duan Ke
Published: August 2019

HAs-30Mg (incorporation of 30% Mg into HA sphere-based scaffolds) induced the optimum new bone formation.
Methane-perylene diimide-based small molecule acceptors for high efficiency non-fullerene organic solar cells
Authors: Li Gang , Yang Wenbin , Wang Shuaihua , Liu Tao , Yan Cenqi , Li Gang , Zhang Yu , Li Dandan , Wang Xinyu , Hao Pin , Li Jiewei , Huo Lijun , Yan He , Tang Bo
Published: August 2019

A high efficiency of 7.58% is obtained in non-fullerene OSCs using PM-PDI3 as the acceptor and PDBT-T1 as the donor.
Self-doping n-type polymer as a cathode interface layer enables efficient organic solar cells by increasing built-in electric field and boosting interface contact
Authors: Wang Yufei , Liang Zezhou , Li Xiaoming , Qin Jicheng , Ren Meiling , Yang Chunyan , Bao Xichang , Xia Yangjun , Li Jianfeng
Published: August 2019

Self-doped polymer cathode interface materials for organic solar cells have been widely investigated to enhance the ohmic contact between the electrode and the photoactive layer.
Spectroscopy and dynamics of a HOF and its molecular units: remarkable vapor acid sensing
Authors: Gomez Eduardo , Suzuki Yuto , Hisaki Ichiro , Moreno Miquel , Douhal Abderrazzak
Published: August 2019

New advances in understanding the photobehaviour of HOFs based on HAT.CBPHAT-1aHOF (crystals) exhibits a strong response to HCl vapors. This ability is observed by eye as a change in its color or in its emission.
Elevated serum macrophage migration inhibitory factor levels correlate with benign paroxysmal positional vertigo and recurrence events
Authors: Cai Hong-Bin , Duan Lei , Tian Ting , Li Zi-Chao , Zhao Chong-Chong , Ge Zhao-Ming
Published: August 2019

Objective: We aimed to assess the possible relations between serum levels of macrophage migration inhibitory factor (MIF), a central cytokine of the innate immunity and inflammatory response, and benign paroxysmal positional vertigo (BPPV) risk and BPPV recurrence events.

Methods: In the present study, 154 patients with BPPV, and 100 age-and sex-matched control subjects were enrolled in the study. All the patients and controls underwent a complete audio-vestibular test battery including the Dix–Hallpike maneuver and supine roll test. In the BPPV group, measurements of MIF levels were repeated 1 month after the vertigo attack. The patients were also divided into the recurrence group and the nonrecurrence group in the 1-year follow-up.

Results: The serum levels of MIF in patients with BPPV were higher than in those controls (13.9[interquartile range {IQR}, 8.9–18.4] ng/ml vs. 9.8[7.8–11.8]; P<0.001). As a continuous variable, MIF was associated with increased risk of BPPV (odds ratio [OR] 1.21, 95% confidence interval [CI]: 1.11–1.39; P=0.004) in multiple regression analyses. Recurrent attacks of BPPV were reported in 35 patients, and those patients had higher levels of MIF than those patients were not recurrence (18.0[IQR, 13.6–22.2] ng/ml vs. 12.6[9.3–16.8] ng/ml). In multivariate models comparing the second (Q2), third (Q3) and fourth(Q4) quartiles against the first (Q1) quartile of MIF, levels of MIF in Q4 were associated with recurrent BPPV, and the odds were increased by approximately 305% (OR = 4.05; 95%CI: 1.65–15.44; P=0.009).

Conclusions: Elevated MIF is positively correlated with BPPV risk and BPPV recurrence events, requiring further efforts to clarify the exact mechanism.
The role of molecular filaments in the origin of the prestellar core mass function and stellar initial mass function
Authors: André Ph. , Arzoumanian D. , Könyves V. , Shimajiri Y. , Palmeirim P.
Published: August 2019

Context. The origin of the stellar initial mass function (IMF) is one of the most debated issues in astrophysics.

Aims. Here we explore the possible link between the quasi-universal filamentary structure of star-forming molecular clouds and the origin of the IMF.

Methods. Based on our recent comprehensive study of filament properties from Herschel Gould Belt survey observations, we derive, for the first time, a good estimate of the filament mass function (FMF) and filament line mass function (FLMF) in nearby molecular clouds. We use the observed FLMF to propose a simple toy model for the origin of the prestellar core mass function (CMF), relying on gravitational fragmentation of thermally supercritical but virialized filaments.

Results. We find that the FMF and the FLMF have very similar shapes and are both consistent with a Salpeter-like power-law function (dN/dlog Mline ∝ Mline−1.5±0.1) in the regime of thermally supercritical filaments (Mline >  16 M⊙ pc−1). This is a remarkable result since, in contrast, the mass distribution of molecular clouds and clumps is known to be significantly shallower than the Salpeter power-law IMF, with dN/dlog Mcl ∝ Mcl−0.7.

Conclusions. Since the vast majority of prestellar cores appear to form in thermally transcritical or supercritical filaments, we suggest that the prestellar CMF and by extension the stellar IMF are at least partly inherited from the FLMF through gravitational fragmentation of individual filaments.
SIXTE: a generic X-ray instrument simulation toolkit
Authors: Dauser Thomas , Falkner Sebastian , Lorenz Maximilian , Kirsch Christian , Peille Philippe , Cucchetti Edoardo , Schmid Christian , Brand Thorsten , Oertel Mirjam , Smith Randall , Wilms Jörn
Published: August 2019

We give an overview of the SImulation of X-ray TElescopes (SIXTE) software package, a generic, mission-independent Monte Carlo simulation toolkit for X-ray astronomical instrumentation. The package is based on a modular approach for the source definition, the description of the optics, and the detector type such that new missions can be easily implemented. The targets to be simulated are stored in a flexible input format called SIMPUT. Based on this source definition, a sample of photons is produced and then propagated through the optics. In order to model the detection process, the software toolkit contains modules for various detector types, ranging from proportional counter and Si-based detectors, to more complex descriptions like transition edge sensor (TES) devices. The implementation of characteristic detector effects and a detailed modeling of the read-out process allow for representative simulations and therefore enable the analysis of characteristic features, such as for example pile-up, and their impact on observations. We present an overview of the implementation of SIXTE from the input source, the imaging, and the detection process, highlighting the modular approach taken by the SIXTE software package. In order to demonstrate the capabilities of the simulation software, we present a selection of representative applications, including the all-sky survey of eROSITA and a study of pile-up effects comparing the currently operating XMM-Newton with the planned Athena-WFI instrument. A simulation of a galaxy cluster with the Athena-X-IFU shows the capability of SIXTE to predict the expected performance of an observation for a complex source with a spatially varying spectrum and our current knowledge of the future instrument.
New Aspects in the Diagnosis and Therapy of Fetal Hypoplastic Left Heart Syndrome
Authors: Graupner Oliver , Enzensberger Christian , Axt-Fliedner Roland
Published: August 2019

Fetal hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease with a lethal prognosis without postnatal therapeutic intervention or surgery. The aim of this article is to give a brief overview of new findings in the field of prenatal diagnosis and the therapy of HLHS. As cardiac output in HLHS children depends on the right ventricle (RV), prenatal assessment of fetal RV function is of interest to predict poor functional RV status before the RV becomes the systemic ventricle. Prenatal cardiac interventions such as fetal aortic valvuloplasty and non-invasive procedures such as maternal hyperoxygenation seem to be promising treatment options but will need to be evaluated with regard to long-term outcomes. Novel approaches such as stem cell therapy or neuroprotection provide important clues about the complexity of the disease. New aspects in diagnostics and therapy of HLHS show the potential of a targeted prenatal treatment planning. This could be used to optimize parental counseling as well as pre- and postnatal management of affected children.
Opioidsubstitutionsbehandlung und Cannabiskonsum
Authors: Schneider Udo , Schäfer Ingo , Hillemacher Thomas , Cimander Konrad F. , Wedekind Dirk , Weirich Steffen , Havemann-Reinecke Ursula
Published: August 2019

Ziel der Studie Mehr als 30 % der Patienten in Opioidsubstitutionsbehandlung konsumieren zusätzlich Cannabis. In dem Artikel werden die Auswirkungen des Konsums von Cannabis im Rahmen einer Opioidsubstitutionsbehandlung dargestellt.

Methodik Narrative Literaturrecherche (Medline, PubMed)

Ergebnisse Der Konsum von Cannabis im Rahmen einer Opioidsubstitutionsbehandlung kann negative Folgen nach sich ziehen.

Schlussfolgerung Der Konsum von Cannabis im Rahmen einer Substitutionsbehandlung sollte mit dem Patienten erörtert werden. Cannabiskonsum stellt grundsätzlich keinen Grund für den Abbruch einer Substitutionsbehandlung dar.
Myelon Stent – a New Technical Procedure to Protect the Spinal Cord Against Tumour Compression
Authors: Eysel Peer , Baltin Christoph , Meyer Carolin
Published: August 2019

A 59-year-old woman with breast cancer who had undergone chemotherapy, three surgical interventions at the thoracic spine, and radiation since 2012, suffered from progressive ataxia caused by a single relapse metastasis resulting in spinal stenosis at thoracic level 6. Therefore, excessive tumour debulking was performed at thoracic levels 4 to 7 and a fully covered, self-expandable stent was placed around the spinal cord at these levels in order to create a mechanical barrier and to prevent the spinal cord from compression by the tumour. Neuromonitoring was performed before, during, and after surgical procedure. Clinically and electrophysiologically, ataxia appeared improved after intervention. Radiologically, no tumour growth was found at thoracic levels 4 to 7 after the intervention.
Plyometric-based Training for Isokinetic Knee Strength and Jump Performance in Cricket Fast Bowlers
Authors: Krishna Sai Aditya , Alwar Thiagarjan Keddin , Sibeko Sandile , Ranjit Shivani , Sivaraman Arumugam
Published: August 2019

Competitive cricket demands a high level of performance from fast bowlers. Ground reaction forces during the landing phase pose a risk for lower limb and lumbar spine injury. Good dynamic knee strength allows the knee to flex to absorb these forces and extend prior to ball release for maximum efficiency. Plyometric training has been shown to improve dynamic strength. There is a lack of literature on this subject for cricket. This study evaluated the effect of a combined plyometric and strength training program on isokinetic knee strength of fast bowlers. Forty-two professional fast bowlers were randomly assigned to a training group (n=21) and a control group (n=21). Both groups underwent isokinetic knee strength and vertical and standing broad-jump testing. Quadriceps and hamstring concentric and eccentric peak torques, bilateral strength asymmetries (BSAs), and dynamic control ratios (DCRs) were evaluated by isokinetic testing. The study group underwent 12 weeks of plyometric training, whereas the control group continued with their own training methods. The study group showed a significant improvement (p<0.05) in jump performance and eccentric strength. There was a reduction in the proportion of bowlers with poor BSA and DCR. Improving dynamic knee strength through plyometric training reduces injury risk and improves performance in cricket fast bowlers.
Innovative Molecular Testing Strategies for Adjunctive Investigations in Hemostasis and Thrombosis
Authors: Ghorbanpour Elham , Lillicrap David
Published: August 2019

Clinicians and scientists in the fields of hemostasis and thrombosis have been among those first to integrate new molecular strategies for the purpose of enhancing disease diagnosis and treatment. The molecular diagnosis and introduction of gene therapy approaches for hemophilia are obvious examples of this tendency. In this review, the authors summarize information concerning three molecular technologies that have reached various stages of translational potential for their incorporation into the clinical management of disorders of hemostasis. Chromatin conformation assays are now being used to capture structural knowledge of long-range genomic interactions that can alter patterns of gene expression and contribute to quantitative trait pathogenesis. Liquid biopsies in various forms are providing opportunities for early cancer detection, and in the context of tumor-educated platelets, as described here, can also characterize tumor type and the extent of tumor progression. This technology is already being trialed in patients with unprovoked venous thrombosis to assess the potential for occult malignancies. Lastly, advances in single cell transcriptome analysis, provide opportunities to definitively determine molecular events in rare cells, such as antigen-specific regulatory T cells, within the context of heterogeneous cell populations.
Bund-Länder-AG Sektorenübergreifende Versorgung: Schwere Geburt
Authors: Spitzer Stefan G.
Published: August 2019

Im Koalitionsvertrag vom 12. März 2018 wurde die Bildung der sich am 24. September 2018 konstituierten Bund-Länder-Arbeitsgruppe sektorenübergreifende Versorgung beschlossen, die bis 2020 zu Grundsatzfragen Arbeitsergebnisse vorzulegen hat. Erste im Mai 2019 in Umlauf gebrachte Zwischenergebnisse können noch nicht überzeugen.
Digitalized service multinationals and international business theory
Authors: Hennart Jean-François
Published: August 2019

Banalieva and Dhanaraj argue that digital service multinationals (DSMNCs) possess a new category of firm-specific advantage (FSA), the network advantage, and that, contrary to extant theory, they use networks as a mode of governance. I review the business models used by DSMNCs, compare them to non-digital ones, and explore what we can learn about them from extant IB theory. I conclude that network advantages are not a new category of FSAs, that networks are not a mode of governance, and that their use by DSMNCs is well explained by extant theory.
Sample preparation by focused ion beam without argon ion milling for quantitative electron holography of p-n junctions
Authors: Gribelyuk M. A. , Mody J. , Kaganer E. , Furkay S. S. , Miller J. , Charsky A.
Published: August 2019

A method is suggested to prepare lamella for quantitative electron holography by focused ion beam without the need for postprocessing. It relies on thinning of a lamella from the back side of the Si substrate and removal of the protective layers with Ga ions with progressively lower energies down to 2 kV. It is shown that variations of the dopant potential across a one-dimensional p+/n junction in Si, which are derived by electron holography and from the results of secondary ion mass spectrometry, agree to much better values than 50 mV. The effect of the protective layer deposited during TEM sample preparation on the results of electron holography was evaluated. The Si oxide protective layer, which was deposited onto the Si surface, showed a limited charging effect while oxidizing the top of the Si surface. The carbon protective layer showed no surface erosion, yet it has revealed strong charging effects. The deposition process of the protective layer needs to be optimized for a given application in future work.
Influence of site preferences on structural and magnetic properties of Cr-Sn substituted SrAl4Fe8O19 hexa-ferrite, an improved ceramic permanent magnet
Authors: Shekhawat Deepshikha , Prajapati Sandeep , Roy P. K.
Published: August 2019

Chromium and tin substituted strontium hexaferrites {SrAl4(Cr0.5Sn0.5)xFe8 − xO19 with x = 0.0, 0.2, 0.4, 0.6, and 0.8} were synthesized by the sol-gel auto-combustion route. Rietveld refinement of X-ray Diffraction patterns was performed to reveal the phase purity, crystal structure, and unit cell parameters, such as lattice constants, bond angles, and bond lengths. Types of bonds were also verified using Fourier Transform Infrared Spectroscopy. Scanning Electron Microscope was used to explore the effect of substitution on the microstructure. Furthermore, the effect of Cr+3 and Sn+4 substitution on magnetic properties was studied using the Magnetic Property Measurement System. The relationship among the allocation of cations over the 5 sublattices of Fe+3 with substitutions was also analyzed. The saturation magnetization and magnetocrystalline anisotropy were calculated by the “Law of Approach to Saturation magnetization (Ms)” technique at room temperature. The maximum Br and (BH)max was theoretically calculated about 7.62 kG and 7.60 MGOe, respectively, for x = 0.60 composition. Cr-Sn substituted Sr-hexaferrite can be proposed for applications as a permanent magnet with a good deal of consistency.