bluuebunny/crossref_metadata_2025 huggingface dataset:
Novel method for producing oleophilic polyurethane foam to remove oil from open water
Authors: Dat Nguyen Huu , Tuan Vu Manh , Huynh Mai Duc , Trung Tran Huu , Trang Nguyen Thi Thu , Thang Dam Xuan , Hoa Kieu Thi Quynh , Giang Nguyen Vu
Published: March 2022

In this study, a novel recyclable, hydrophobicity foam with excellent oil/water separation based on polyurethane (PU) and polypropylene glycol (PPG) grafted stearic acid (PGGA) has been developed. PGGA was simply synthesized by the esterification of stearic acid and PPG, while the PU/PGGA foam was fabricated by the reaction of PPG and methyl diphenyl diisocynate (MDI) with the addition of PGGA. The PU/PGGA foam exhibits improved oil adsorption capacity, water rejection as well as oil/water selectivity with the increase of PGGA weight loadings. The presence of PGGA at high loading (≥ 5 wt.%) reduces the pore size and porosity of PU/PGGA foam due to the high viscosity of PGGA preventing the foam formation reaction. As a result, the oil adsorption capacity of PU/PGGA foam is slightly neglected, nevertheless, the oil/water selectivity is significantly enhanced compared to the original PU foam. The result in this work suggests a simple and cost-effective method with potential in oil removal at large scale application.
The crop residue conundrum: maintaining long-term soil organic carbon stocks while reinforcing the bioeconomy, compatible endeavors?
Authors: Andrade Christhel , Clivot Hugues , Albers Ariane , Zamora-Ledezma Ezequiel , Hamelin Lorie
Published: March 2022

Crop residues are key for supplying carbon to the bioeconomy without interfering with food security. However, it is often suggested to export no more than half of this potential to ensure the maintenance of soil organic carbon (SOC) stocks. In this study, we challenge this idea by assessing how the residues usage for the bioeconomy is intertwined with the maintenance of long-term SOC stocks and thus the amount that can safely be harvested. We considered the coproduct return to the soil from five bioeconomy scenarios: i) pyrolysis biochar, ii) gasification biochar, iii) hydrothermal liquefaction hydrochar, iv) anaerobic digestion digestate, and v) lignocellulosic ethanol molasses. To compare the long-term SOC changes from these scenarios against a business-as-usual (BAU) scenario, in which crop residues are unharvested, we developed a framework coupling a SOC model with a bioeconomy module, that we applied at high spatial resolution to cover over 60,000 combinations of crop rotations and pedoclimatic units over France, for 2020 – 2120. The adapted SOC model considers the recalcitrance to degradation of each coproduct, while the bioeconomy module determines the share of carbon from the crop residues allocated to the coproducts. Our results show that the available harvestable crop residues could be completely harvested if pyrolysis or gasification biochar returns to soils, with SOC expected to double compared to the BAU scenario. Replacing crop residues with hydrochar showed increased SOC stocks in 88% of the areas (max +8%), while the digestate scenario predicted minor SOC increases in 50% (max +0.76%) and decreases in 40% of the areas (min -4%). The molasses scenario yielded SOC losses in all the areas and is thus not recommended. Excluding these, an additional amount of 60.4 – 191 PJ of crop residues (use-dependent) could be available for the French bioeconomy compared to applying a universal removal rate of 31.5%.
Ecological Traits Affect The Seasonal Migration Patterns Of Resident Birds Along A Subtropical Altitudinal Gradient
Authors: Cheng Yuwen , Wen Zhixin , He Xingcheng , Dong Zhehan , Zhangshang Mingyu , Li Dongrui , Wang Yan , Jiang Yong , Wu Yongjie
Published: March 2022

Background: Altitudinal bird migration involves seasonal shifts up and down the altitude gradient annually. Asia as the place with the largest number of altitudinal migrants, has quite few related studies, especially for montane and temperate avifaunas.Method: To explore the potential drivers of seasonal altitudinal migration for birds in the middle of Hengduan Mountains, we conducted a two-year investigation on breeding and non-breeding season bird communities at eight altitude sections in the Gongga Mountains. Then, we examined the altitudinal migration patterns and relationships between seasonal distribution shifts and species’ traits, of 20 species with sufficient data recorded in both seasons.Results: We found that a large proportion of resident birds underwent altitudinal migration and showed 3 patterns (downslope shift, upslope shift, no shift). Species’ seasonal distribution shifts were mainly correlated with territoriality, nest height, diet, and temperature tolerance range. The species nesting in scrub and omnivores were more likely to present a downhill movement in the non-breeding season. In addition, territorially weaker species migrated more widely and performed multiple patterns. Notably, HWI dominated upslope shifts in altitudinal migration.Conclusion: Studying the seasonal altitudinal migration patterns of birds is essential to understanding their distributional responses to seasonal changes in climate (energy), which has important conservation implication for avian biodiversity. These results further consolidate the study of seasonal altitudinal migration in montane birds and verify that body mass is not correlated with altitudinal migration. This could be used to bridge existing knowledge gaps that currently impeding effective conservation.
Comprehensive Analysis of Differentially Expressed miRNAs in Patients with Ischemic Stroke and Development of a New Risk Prediction Nomogram
Authors: Gao Mengxi , Wang Yan , Liu Chengyuan , Meng Lingzhen , Zhang Xiaokun , Chen Li , Zhang Qin , Guo Liru
Published: March 2022

The aim of our study was to investigate the microRNAs (miRNA) associated with ischemic stroke (IS) and developed a new risk prediction nomogram. Gene expression profiles were obtained from public databases. Differentially expressed miRNAs (DEmiRNAs) and differentially expressed mRNAs (DEmRNAs) were identified; Then, the transcription factors (TFs) of DEmiRNAs were predicted and Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis on DEmRNAs were performed; Then, the miRNA-mRNA network and the competitive endogenous RNA (ceRNA) network were constructed, and the support vector machine (SVM) model was used to further screen key miRNAs. The differential expression of the key miRNAs was verified via experiment. Finally, we combined the patients’ disease characteristics and the expression of key miRNAs to construct a risk prediction nomogram. A total of 111 DEmiRNA and 501 DEmRNA were obtained. Top 3 TFs of DEmiRNA were SP1, EGR1 and SP4. GO enrichment analysis on the DEmRNAs showed that they were mainly related to neutrophils and immune activation. Hematopoietic cell lines and cell adhesion molecules were significantly enriched KEGG pathways. MiR-140-3p, miR-34c-5p, miR-330-3p had higher degree in the networks we constructed. In the nomogram, the level of cholesterol, the level of low-density lipoprotein, hypertension, diabetes, the expression of miR-140-3p, miR-34c-5p, and miR-330-3p were related to IS. The current results indicated that hematopoietic cell lineage, cell adhesion molecules, phagosomes, and T cell receptor signaling pathways were important pathways in IS. MiR-140-3p, miR-34c-5p, and miR-330-3p may play a pivotal role in the pathogenesis and progression of IS, and may be potential new therapeutic targets for IS.
Cumulative Smoking Exposure In The Non-Demented Older People And The Risk Of Cognitive Decline (NEDICES)
Authors: Benito-León Julián , Ghosh Ritwik , Contador Israel , Lapeña José , Bermejo-Pareja Felix
Published: March 2022

Background: Whether cumulative smoking exposure is a risk factor for cognitive decline among older adults remains majorly unresolved. We assessed whether cumulative smoking exposure in non-demented older people was associated with a higher risk of cognitive decline.Methods: Baseline cigarette smoking habits were assessed in 2,624 non-demented elderly (≥65 years) Spanish participants. A 37-item version of the Mini-Mental State Examination (MMSE) was administered at two visits (baseline and follow-up, approximately three years later). Change in 37-MMSE (baseline 37-MMSE score − follow-up 37-MMSE score) was divided into tertiles (lower tertile ≥2 points improvement in score, higher tertile ≥2 point decline in score). We dichotomized this variable into higher (cognitive decline) vs. middle and lower tertiles for the current analyses.Results: Any cumulative smoking exposure, regardless of intensity, was associated with a higher risk of cognitive decline, with a non-linear dose-response. Multivariable-adjusted hazard ratios for higher risk of cognitive decline were 1.00 (reference) in the never smokers, 1.32 (95% confidence interval 1.0-1.74) in the lower tertile of pack-years (<19), 1.55 (1.15-2.07) in the middle tertile of pack-years (19-47), and 1.83 (1.36-2.47) in the higher tertile of pack-years (>47). Multivariable-adjusted hazard ratios for higher risk of cognitive decline were 1.00 (reference) in the never smokers, 1.37 (1.03-1.83) in former smokers, and 1.57 (1.23-2.02) in current smokers. Conclusions and relevance: The association between cumulative smoking exposure and cognitive decline in the elderly population was dose-dependent. Results underscore the cognitive health risk of smoking and the potential benefits of quitting it.
Prognostic Implication of Early Minimal Residual Disease Evaluation in Patients with Chronic Myelomonocytic Leukemia
Authors: Wang Lulu , Chen Rongrong , Li Li , Zhu Lixia , Huang Xianbo , Ye Xiujin
Published: March 2022

Background: This article is performed to assess the significance of minimal residual disease (MRD) after one course of therapy in patients with chronic myelomonocytic leukemia (CMML). Methods: From January 2010 to January 2022, a total of 158 patients who were newly diagnosed with CMML were enrolled, in which 58/158 (37%) patients were conducted by multiparameter flow cytometry (FCM) assessed MRD analysis after on cycle treatment and were included in this study. MRD was detected by six- to eight- colour FCM. Result: After one course of therapy, twenty-one (36%) patients achieved MRD<0.01% (MRD1-) and thirty-seven (64%) were MRD>0.01% (MRD1+). The patients in the MRD1+ group had lower platelet counts, higher 𝛽2-microglobulin, ferritin and BM1 myeloblasts (bone marrow myeloblasts after one cycle of therapy) than that of the MRD1- group (P=0.005, P=0.023, P=0.026 and P=0.007, respectively). Furthermore, a greater propotion of patients had JCK2 and SETBP1 mutation in MRD1- patients than in MRD1+ group (both P=0.037). At a median follow up time of 25.8 months (95%CI, 15.01-36.59), those patients who achieved MRD<0.01% after one course of therapy fared better prognosis in terms of both OS (overall survival, 54.9 months vs. 17.5 months; P<0.001) and PFS (progression-free survival, 52.3 months vs 11.9 months; P=0.006) than those of MRD>0.01%, and 2-year OS rate (90% vs. 30%; P<0.001) and 2-year PFS rate (70% vs. 7%; P=0.004) were also higher. MRD1 status could determine the likelihood of progression after hematopoietic stem cell transplantation (HSCT), the 2-year PFS rate (100% vs. 24%, P=0.04) was higher in MRD1+ group than MRD1- group at the post-HSCT assessment. In addition, MRD1 status were independent prognostic factor of both PFS (HR, 3.326 [95%CI, 1.340-8.259]; P=0.01) and OS (HR, 4.614 [95%CI, 1.266-16.812]; P=0.02). Conclusion: MRD is highly predictive of prognosis, and it may help identify patients at increased risk for progression to further improve the management of patients with CMML. Large-scaled investigations are warranted to validate our conclusions and its potential in clinical practice.
Uncertainty analysis of water environmental capacity based on the copula model
Authors: Li Jiaqi , Shen Zhenyao , Cai Jianying , Liu Guowangchen , Chen Lei
Published: March 2022

Water environmental capacity is an important factor in total pollutant control and water environmental management. Due to the uncertainty of the water environment, the uncertainty analysis of water environmental capacity is crucial. Most uncertainty analyses of water environmental capacity do not consider the correlation between various parameters that were used to calculate water environmental capacity. In this study, the copula model of discharge and water quality was constructed to analyze the uncertainty of water environmental capacity. The risk threshold of each river section was calculated when the water environmental capacity was less than 0 in the wet, normal and dry seasons. The Yitong River Basin in Changchun city was taken as a case study. The results showed that the 68.27% confidence level was considered to reduce the uncertainty of water environmental capacity by more than 54.90%. The uncertainty of water environmental capacity in the wet season was the largest, and the risk threshold was the smallest. The risk thresholds for the water environmental capacity of each river reach were all greater than 90% in the dry season. The method of this study can be extended to other basins for uncertainty analysis of water environmental capacity.
Geostatistical analysis of the water quality of an aquifer in tropical and agricultural zone
Authors: Bustos-Terrones Yaneth , García Blanca , Loaiza Juan , Rangel-Peraza Jesús , Ramírez-Pereda Blenda , Rojas-Valencia María Neftalí Neftalí
Published: March 2022

The objective of this study was to identify water pollution problems and obtain useful information for the sustainable extraction of water from the Culiacan River aquifer. Data from 6 sampling sites were used in the period from 2012 to 2019. A spatial geostatistical analysis was carried out to describe the water quality of the aquifer by using isoconcentration contours. Likewise, a hydrogeochemical evaluation was carried out using seven water quality indices for irrigation purposes (SAR, CSR, SSP, KR, % Na, MH, PI). Finally, a multivariate statistical analysis was obtained through the analysis of principal components, Pearson correlation and cluster analysis identified the most important water quality variables in the Culiacan River aquifer based on their variability. The water quality index showed that the aquifer water quality was good in five sampling sites and excellent in one sampling site. Based on average concentrations, the ion content was Na2+ >HCO3- >Ca2+ >Mg2+ >Cl- >SO42- >K+, which did not present any ecological or public health risk. Finally, Sample Point 1 (SP1) was the location most affected by anthropogenic contamination. This site is within an urban area and is the shallowest sampling well.
A computational framework to trace tumor tissue-of-origin of 19 cancer types based on RNA sequencing
Authors: Wang Bo , Yang Huandong , Zhang Yanxiang , Tian Geng , Yang Jialiang
Published: March 2022

Carcinoma of unknown primary (CUP) is a type of metastatic cancer with tissue-of-origin (TOO) unidentifiable by traditional methods. Most CUP patients have poor prognosis since no therapy targeting TOO is allowed. Thus, it’s critical to develop accurate computational methods to infer TOO. While qPCR or microarray-based methods are effective in predicting TOO for most cancer types, the overall prediction accuracy is yet to be improved. Here, we propose a computational framework to trace TOO of 19 cancer types based on RNA sequencing (RNA-seq). Specifically, we download the RNA-seq data of 7000+ tissue samples covering 19 cancer types with known TOO from TCGA. By feature selection, 90 genes are finally selected to train a random forest model for TOO inference; the 90 genes are enriched in both tissue-specific functions and tissue-general functions. The cross-validation accuracy of our framework reaches 97.55% across all cancer types. Furthermore, we collected an independent cohort of samples in GEO as testing samples. The accuracy on the independent data is 74% despite the differences in experiment procedures and pipelines. In conclusion, we develop an accurate yet robust computational framework for identifying TOO, which might be promising in clinical applications.
Breast Metastasis Of Signet Ring Cell Carcinoma From The Colon: A Case Report
Authors: Wang Xiao , Lu Yanwei
Published: March 2022

Background: Colon cancer is one of the most common diagnosed malignancies. Although the use of surgery, chemotherapy, radiotherapy, targeted therapy, immunotherapy and other comprehensive treatment, distant metastasis is still one of the main causes for dying of colon cancer. The common metastatic site of colon cancer is liver, lung and bone. In this article, we report a rare case of breast metastasis of signet ring cell carcinoma from the colon. Case Presentation: A 44-year-old woman was diagnosed with colon cancer and received a radical surgery of colon cancer in 2019. Combined with postoperative pathological and CT images, a diagnosis of cT3N2M0 mucinous adenocarcinoma of colon (according to AJCC cancer staging manual, Version 8) was established. Adjuvant chemotherapy (XELOX: oxaliplatin 130 mg/m2 on day 1 plus capecitabine 1000 mg/m2 twice daily on days 1 to 14 every 3 weeks for 18 weeks) was performed followed by surgical resection. 14 months later, the patient received mastectomy for breast mass, which was diagnosed pathologically as metastasis of signet ring cell carcinoma from the colon. XELOX chemotherapy regimen (oxaliplatin 130 mg/m2 on day 1 plus capecitabine 1000 mg/m2 twice daily on days 1 to 14 every 3 weeks for 24 weeks) combined with bevacizumab (7.5mg/kg on day 1) were used after the mastectomy. The patient was stable disease according to her last examination (RECIST criteria).Conclusion: It is rare to report a patient diagnosed with colon cancer which metastasis to breast. We hope to increase treatment experience for patients with this rare metastasis.
Precision Public Health Initiatives in Cancer: Proceedings from the Transdisciplinary Conference for Future Leaders in Precision Public Health
Authors: Allen Caitlin G.
Published: March 2022

Background.
Precision public health is an emergent field that requires transdisciplinary collaborations that leverage innovative approaches to improve population health. These opportunities have inspired a new generation of precision public health researchers. Despite burgeoning interest in precision public health, there are limited opportunities for researchers to convene and continue the momentum of this field.
Methods.
The Transdisciplinary Conference for Future Leaders in Precision Public Health was the first event to bring together international researchers and practitioners to learn, network, and agenda set for the future of the field. The conference took place virtually on October 14 and 15, 2021.
Results.
The conference spanned two days and featured a keynote address, speakers from public health disciplines who are international leaders in precision-based research, networking opportunities, a poster session, and productive research agenda setting activities.
Conclusion.
The conference was a critical first step to creating a shared international conversation about precision public health, especially among early-stage investigators. This allows us to continue to build individual skills and international collaborations, and to grow the field of precision public health.
Co-assembled Perylene/GO Photosensitive Heterobilayer for Efficient Neuromorphics
Authors: Zhang Heshan , Dong Xue-Mei , Zhang Zi-Cheng , Zhang Ze-Pu , Ban Chaoyi , Zhou Zhe , Song Cheng , Yan Shiqi , Xin Qian , Liu Juqing , Li Yin-Xiang , Huang Wei
Published: March 2022

Neuromorphic electronics, which use artificial photosensitive synapses, can emulate biological nervous systems with in-memory sensing and computing abilities. Benefiting from multiple intra/interactions and strong light-matter coupling, two-dimensional heterostructures are promising synaptic materials for photonic synapses. Two primary strategies, including chemical vapor deposition and physical stacking, have been developed for layered heterostructures, but large-scale growth control over wet-chemical synthesis with comprehensive efficiency remains elusive. Here we demonstrate an interfacial coassembly heterobilayer films from perylene and graphene oxide (GO) precursors, which are spontaneously formed at the interface, with highly uniform bilayer structure of single-crystal perylene and well-stacked GO over centimeters in size. The planar heterostructure device exhibits an ultrahigh specific detectivity of 5.01×1016 Jones and ultralow energy consumption of 10− 9 W as well as broadband photoperception from 365 to 1550 nm. Moreover, the device shows extraordinary photonic synaptic behaviors with a paired-pulse facilitation (PPF) index of 214% in neuroplasticity, and the heterosynapse array has the capability of information reinforcement learning and recognition.
Real-Time Gait Phase Detection on Wearable Devices for Unsupervised Gait
Authors: Wu Jiaen , Becsek Barna , Schaer Alessandro , Maurenbrecher Henrik , Chatzipirpiridis George , Ergeneman Olgac , Pané Salvador , Torun Hamdi , Nelson Bradley
Published: March 2022

Detecting gait phases unobtrusively and reliably in real-time for long-term unsupervised walking is important for clinical gait rehabilitation and early diagnosis of neurological diseases. Due to hardware limitations in wearable devices, real-time gait phase detection remains a challenge for unsupervised mobility assessment. In this work, a hybrid algorithm combining a reduced support vector machine (RSVM) and a finite state machine (FSM) is developed to address this. The RSVM is developed by reducing the SVM model size for real-time applications through a novel technique based on K-means clustering, and the FSM validates predictions and corrects misclassifications of RSVM. With the proposed algorithm, the model size is reduced by 88%, and the computation time is reduced by a factor of 36, with only a minor degradation in performance. The real-time classification performance of the algorithm is evaluated by twenty healthy subjects walking outdoors with unsupervised gait. The proposed algorithm demonstrated promising real-time performance, with the accuracy, sensitivity, and specificity of 91.51%, 91.70%, 95.77% across all test subjects.
Field-tuned chiral transport in charge-ordered CsV3Sb5
Authors: Guo Chunyu , Putzke Carsten , Konyzheva Sofia , Huang Xiangwei , Gutierrez-Amigo Martin , Errea Ion , Chen Dong , Vergnior Maia , Felser Claudia , Fischer Mark , Neupert Titus , Moll Philip
Published: March 2022

When conductors differ from their mirror image, their chirality is reflected in the electron states and their dynamics. Conventionally, mirror symmetries are broken by the atomic structure of crystals and imprint their low symmetry onto the itinerant electron states. Unusual transport properties are a hallmark of chiral crystals, such as a non-linear electric response known as electronic magneto-chiral ansiotropy (eMChA). Here we report such a transport signature in the centro-symmetric layered Kagome metal CsV3Sb5, observed via second harmonic generation under magnetic field. We observe the signal in a charge-ordered phase of the material, which has been proposed to be a loop-current phase with spontaneously broken mirror symmetries. While charge ordering sets in at TCDW ≈ 94 K, the eMChA transport becomes significant only at temperatures below T'≈ 34 K, indicative of further evolutions of this ordered phase upon lowering the temperature. Crucially, we demonstrate that the nonlinear magnetotransport can be switched by small out-of-plane fields, in accordance with recent tunneling microscopy experiments. Unlike structurally chiral materials, our results demonstrate how the electronic chirality of a metal can be tuned and even abruptly switched by small changes in magnetic fields alone -- a prerequisite for their applications in chiral electronics.
Assessment of Electrocardiogram Interpretation Competency among Health Professional staff and Students of Ardabil University of Medical Sciences: A Multidisciplinary Study
Authors: Amini Keyvan , mirzaei alireza , Hosseini Mirtohid , Zandian Hamed , Azizpour Islam , Haghi Yagoob
Published: March 2022

BackgroundElectrocardiogram (ECG) interpretation is a core clinical skill that helps to rapid diagnosis of potentially life-threatening diseases. Misinterpretation of the electrocardiogram can lead to inappropriate clinical decisions with adverse outcomes. The main aim of this survey was to assess the competency of electrocardiogram interpretation and related factors among Health Professional staff and Students of Ardabil University of Medical Sciences. MethodsThis descriptive cross-sectional study included 323 staff and students of Ardabil University of Medical Sciences in northwestern Iran. Data were collected randomly from November to January 1400 using the Badell-Coll ECG Interpretation Competency Questionnaire and analyzed using SPSS V.14. Statistical analysis included descriptive statistics, independent t-test, ANOVA, Pearson correlation coefficient and multiple linear regression.ResultsThe results showed that the mean and standard deviation of electrocardiogram interpretation competency of health professional staff and students was 5.13 ± 2.25 (maximum score = 10). The large number of participants wasn't able to identify normal sinus rhythm (n = 251, 77.3%), acute myocardial infarction (n = 206, 63.8%) and pathological Q (n = 201, 62.2%). The results of multiple linear regression showed that the variables of education level, self-assessment of electrocardiogram interpretation competence, work experience, and type of hospital were able to predict the competence of ECG interpretation in participants.ConclusionsOur findings showed that the participants' level of electrocardiogram interpretation competency was low. Hence, regular, standard training and education are recommended. Also, managers and educators of the health system should consider the role of positive self-assessment and exposure to ECG interpretation in improving the competence of staff and students to interpret ECG.
Insights into regulating mechanism of mutagenesis strains of Elizabethkingia meningoseptica sp. F2 by omics analysis.
Authors: Yang Qiang , zheng zhiming , Wang Peng , Wang Li , Wang Han , Zhang Mengxue , Zhao Genhai
Published: March 2022

Vitamin K2 plays an important role in electron transport, blood coagulation, and calcium homeostasis; therefore, researchers have attempted to improve vitamin K2 production in Elizabethkingia meningoseptica. Our previous work revealed that gradient radiation, breeding, and culture acclimation could improve the vitamin K2 yield in Elizabethkingia meningoseptica, but the mechanism remains elusive. Thus, this study is the first which performs genome sequencing of Elizabethkingia meningoseptica sp. F2 as a basis for subsequent experiments and further comparative analyses with other strains. Comparative metabolic pathway analysis of E. meningoseptica sp. F2, E. coli, Bacillus subtilis, and other vitamin K2 product strains revealed that the mevalonate pathway of Elizabethkingia meningoseptica sp. F2 is different in bacteria at the system level. Furthermore, a Quantitative real-time RT-PCR was conducted to determine vitamin K2 biosynthetic gene expression in different developmental phases and strains of Elizabethkingia meningoseptica. The results demonstrated that MenA, MenD, MenH, and MenI of the menaquinone pathway and IDI, HMGR, and GGPPS of the mevalonate pathway had a higher expression compared to the original strain. In addition, isobaric tags for relative and absolute quantitation techniques have been applied in proteomic studies. A total of 67 differentially expressed proteins were identified. These proteins are mainly involved in the oxidative phosphorylation metabolism pathway and the citrate cycle (TCA cycle). Therefore, our results reveal that combined gradient radiation breeding and culture acclimation can promote vitamin K2 accumulation by regulating the vitamin K2 pathway, oxidative phosphorylation metabolism pathway, and the citrate cycle (TCA cycle).
Informelles Lernen auf YouTube
Authors: Honkomp-Wilkens Verena , Wolf Karsten D. , Jung Patrick , Altmaier Nina
Published: March 2022

Erklärvideos und Tutorials auf YouTube stellen zentrale Elemente lern- und bildungsbezogener Medienrepertoires von Jugendlichen und jungen Erwachsenen dar. Sie zeichnen sich durch einen besonders niedrigschwelligen Zugang zu Wissen und Bildungsinhalten aus. Weitgehend ungeklärt ist bisher, wie sich Erklärvideos und Tutorials in ihrer didaktischen und audiovisuellen Gestaltung zu verschiedenen Themenfeldern unterscheiden. In diesem Beitrag werden dazu die Weiterentwicklung eines Kodierleitfadens «Gestaltungsqualität von Erklärvideos» (GQEV) beschrieben und erste Analyseergebnisse vorgestellt. Für die Analyse wurde eine Videokorpus von 382 deutsch- und englischsprachigen Erklärvideos zu typischen Themenfeldern des ausserschulischen interessenbasierten Lernens Jugendlicher und junger Erwachsener ausgewertet. Bei der didaktischen Gestaltung werden besonders häufig eine «Themeneinführung» sowie eine «Verabschiedung» genutzt, relativ selten eine «Darstellung des Ergebnisses zu Beginn des Videos» oder eine «theoretische Herleitung». Die nach 17 Themenfeldern differenzierte Analyse kann die These stärken, dass einzelne Gestaltungsmerkmale in Passung zum erklärenden Videoinhalt unterschiedlich häufig eingesetzt werden. In einigen Themenfeldern wie «Musik machen» und «Kreatives Gestalten» ähneln sich die Gestaltungsformate dabei stärker als in anderen Themenfeldern wie «Produkttests» oder «Persönlichkeit und Beziehung». Über alle Themenfelder hinweg werden Gestaltungselemente wie «Themeneinführung» sowie «Humor» in einem ähnlichen Umfang genutzt, während der Einsatz «Inhaltlicher Wiederholungen» oder «Inhaltlicher Quellen» stärker variiert.
Unangemessene Behandlung von Medizinstudierenden: ein Vergleich mit anderen Studiengängen
Authors:   , Bormuth Sonia Marie
Published: March 2022

In dieser Dissertation wird der Frage nachgegangen, inwiefern sich unangemessene Behandlung in der praktischen Ausbildung zwischen Medizinstudierenden und Studierenden anderer Studienfächer unterscheidet. Zudem wird untersucht, welcher Einfluss der Hierarchie im angestrebten Beruf von den Probanden diesbezüglich zugemessen wird. Auch wird untersucht, wie sich Persönlichkeitsmerkmale auf die Wahrscheinlichkeit, unangemessene Behandlung zu erleben, auswirken.
Mikrowellenablation von kolorektalen Metastasen, Outcome und Prognosefaktoren – eine retrospektive Studie
Authors:   , Zitsch Maximilian
Published: March 2022

Purpose: The aim of this study was to evaluate the survival rates (SR), overall survival time (OST), local progression-free survival (PFS) and prognostic factors of patients with colorectal cancer liver metastases (CRLM) undergoing microwave ablation (MWA). Method: We retrospectively enrolled 132 patients who had been treated between 2010 and 2018. For the evaluation of the SR and the OST, all patients were divided according to their indications (curative and palliative). In total, 257 ablations were evaluated for prognostic factors (number of liver metastases, primary tumor origin (PTO), diameter, volume of lesions, duration and energy of ablation. Results: On a total of 132 patients 57 patients underwent a curative procedure and 75 patients received a palliative treatment. Median overall survival was 32.1 months with 93.2% of patients reaching a median recurrence-free survival of 28.3 months. The 1- year and 3- year overall survival rates were 82.72% and 41.66% respectively. On a cohort-based analysis, the median survival and recurrence-free survival of the curative group were higher than the palliative group. The difference in survival and recurrence free survival between both groups was statistically significant (p <0.001). Statistically significant prognostic factors included the location of the primary tumor (p<0.038) and the number of lesions (all p < 0.017). Lesion diameter and volume and ablation duration and energy had no significant correlation with survival (p > 0.05). Conclusions: MWA of CRLM showed better overall survival and progression free survival in patients treated with curative compared to palliative intention. Prognostic factors influencing the survival of patients include the number of lesions and the location of the primary tumor. The lesion’s size and the duration and energy used for ablation were not of significant prognostic value.
Sub-GeV dark matter models and direct detection
Authors: Lin Tongyan
Published: March 2022

Lecture notes for Les Houches Summer School 2021: Dark Matter. These lectures give a brief introduction to sub-GeV dark matter models, and then reviews theory and approaches to direct detection of sub-GeV dark matter.
Valorization of Hesperidin from Citrus Residues: Evaluation of Microwave-As
Authors: da Silva Danielle , Bomfim João , Marchi Rafael , Amaral Jéssica , Pinto Luciano , Carlos Rose , Ferreira Antonio , Forim Moacir , Fernandes João , da Silva Maria , de Oliveira Regiane , Buss David , Kirk William , Bruce Toby
Published: March 2022

The aim of the current study was the valorization of hesperidin, the dominant flavonoid in citrus processing waste, by microwave-assisted synthesis of hesperidin-Mg complex, improving its antioxidant activity and insecticidal potential. Here we show, for the first time, that microwaveassisted synthesis of [Mg(hesp)2(phen)]OAc (1) (hesp: hesperidin, phen: phenanthroline) improve the reaction rate and yield. The nuclear magnetic resonance (NMR) experiments proved to be powerful tools for the identification of three isomers in metal complexes. Moreover, we explore the insecticidal potential of 1 and [Mg(phen)2(Isov)]OAc (2) (Isov : isovanillic acid) complexes against three insects. Complex 1 killed 80% of adults whitefly at 0.14 μmol L-1, and 2 76% at 0.36 μmol L-1. There was a total mortality of Spodoptera frugiperda with 2 at 0.39 μmol L-1, and 83% with 1 at 0.14 μmol L-1. Both have similar activity, and represent a novel group of insecticide for Bemisia tabaci and S. frugiperda; nevertheless, the benefits of both as Myzus persicae repellent require further evaluation.
Pengaruh Celebrity Endorsement terhadap Sikap Pelanggan Akan Merek dan Intensi Pembelian Pada Suatu Produk Kosmetik Rintisan
Authors:   Sekolah Bisnis dan Ekonomi, Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Yulia Evelynn , Estella Isabelle ,   Sekolah Bisnis dan Ekonomi, Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Istijanto Istijanto ,   Sekolah Bisnis dan Ekonomi, Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Yudianto Bernardinus Realino ,   Sekolah Bisnis dan Ekonomi, Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339
Published: March 2022

Akibat adanya perkembangan zaman, penggunaan strategi Celebrity Endorsement telah menjadi metode baru yang berkembang di dalam mempromosikan suatu produk atau merek. Diharapkan dengan menggunakan celebrity yang tepat, hal ini dapat membentuk pandangan positif pelanggan terhadap produk atau merek yang dipromosikan sehingga akhirnya berhasil membawa pelanggan kepada ketertarikan serta intensi pembelian. Penelitian ini bertujuan untuk melengkapi penelitian sebelumnya dari Ha & Lam (2017) yang dilakukan di Vietnam dengan menambahkan variabel baru yang termasuk ke dalam Celebrity Endorsement yaitu variabel Celebrity Authenticity. Selain itu penulis juga menggunakan metode analisis SEM dimana penelitian sebelumnya memutuskan untuk menggunakan analisis sederhana yaitu metode regresi. Pada penelitian ini, penulis menggunakan metode kuantitatif dimana penulis berhasil mengumpulkan 302 responden selama 2 minggu mulai dari 2 Juli 2019 sampai dengan 15 Juli 2019. Setelah berhasil mengumpulkan dan mengolah data, penulis melihat bahwa hasil penelitian menunjukan adanya pengaruh positif antara variabel pada Celebrity Endorsement terhadap variabel Sikap Pelanggan Akan Merek. Namun variabel dari Celebrity Endorsement yang terbukti memiliki pengaruh positif terhadap variabel Sikap Pelanggan Akan Merek ialah: Celebrity Trustworthiness, Celebrity Similarity, Celebrity Liking, Celebrity Familiarity, Celebrity Match-Up Congruence with The Brand/ Product dan Celebrity Authenticity dengan 2 variabel yang tidak memiliki hubungan positif yaitu Celebrity Expertise dan Celebrity Attractiveness. Terakhir, penulis juga menemukan bahwa variabel Sikap Pelanggan Akan Merek menunjukan pengaruh yang positif pula terhadap variabel Intensi Pembelian. Maka dari itu, terbukti bahwa dengan memilih dan menggunakan celebrity yang memiliki variabel positif terhadap variabel Sikap Pelanggan Akan Merek dapat membawa pelanggan dari suatu produk kosmetik rintisan kepada tahapan intensi pembelian.
COVID-19 Salgın Sürecinde Görsel Sanatlar Öğretimi: Görsel Sanatlar Öğretmenlerinin Deneyimleri Üzerine Bir Durum Çalışması
Authors: TEKİN KARAGÖZ Ceren , MAMUR Nuray
Published: March 2022

Bu araştırmanın amacı, COVİD-19 salgın sürecinde öğretmenlerin çevrimiçi ortamlarda yürüttükleri görsel sanatlar dersine yönelik deneyimlerinin incelenmesidir. Araştırma, nitel araştırma yaklaşımlarından “bütüncül tek durum” deseninde yapılandırılmıştır. Araştırmanın katılımcıları Milli Eğitim Bakanlığı okullarında ve okul dışı öğrenme kurumlarında görev yapan toplam 30 görsel sanatlar öğretmenidir. Araştırma verileri açık uçlu sorulardan oluşan bir anket formu ve yarı yapılandırılmış görüşme yoluyla toplanmıştır. Veriler içerik analizi yöntemi ile çözümlenmiştir. Araştırma sonuçları; uzaktan eğitimin başlangıçta öğretmenleri çevrim içi ortamda uygulama içerikli bir dersi yürütme, ders akışını planlama, öğrenciyi derse motive etme ve katılımı sağlama, öğrenciyi izleme ve değerlendirme gibi süreçlerde zorladığını ancak zamanla öğretmenlerin dijital yetkinlikleri geliştirmeye yönelik aldıkları eğitimlerle kendilerini güçlendirdiklerini ve ders süreçlerini daha verimli hale getirdiklerini göstermektedir. Bazı öğrencilerde teknolojik alt yapı ve internete erişimden kaynaklı eksiklikler öğretmenler için dersi yürütme ve sınıfında eşitliği sağlama konusunda en temel sorun olmuştur. Öte yandan uzaktan eğitim dijital sanat üretim yaklaşımlarını ve bilgi temelli sanatsal içeriğin aktarımını destekleme, müze içeriklerine erişimin ve ders sürecine aktarımın kolaylaşması, sanat dünyası ile deneyim paylaşımının artması, öğrencinin bireyselliğini destekleme bağlamında görsel sanatlar eğitimine katkı sunma potansiyeline sahip olarak değerlendirilmiştir.
Avaliação da Perda Sanguínea em Paciente Submetida à Cirurgia Oncológica Mamária: Relato de Caso
Authors: Mariano da silva Augusto Cesar , Bueno Badan Giovanna , Da silva sá Rafael
Published: March 2022

No Brasil, estima-se um aumento constante de novos casos de câncer de mama, sendo que o carcionoma invasivo do tipo não especial (CINE) é o tipo histológico maiscomum, com cerca de 85% dos casos, podendo apresentar chances de cura de 95% quando diagnosticado e tratado em estado inicial. É importante considerar que adepender do tratamento indicado, há riscos de sangramento e necessidade de transfusão sanguínea. Neste jaez, importante salientar que o Brasil é considerado o terceiro paíscom maior número de Testemunhas de Jeová no mundo, religião que possui como crença a não aceitação da transfusão de sangue. No presente relato de caso, através darevisão de prontuários, relatamos o procedimento realizado em uma mulher, Testemunha de Jeová, de 49 anos, que apresentou câncer de mama, sendo submetida àquadrantectomia associado à biopsia de linfonodo sentinela, com volume de 25g de perda sanguínea, apresentando pós-operatório imediato e tardio sem complicações, nãonecessitando de transfusão sanguínea. Com efeito, todos os profissionais da área da saúde podem se deparar com diagnósticos semelhantes, e uma vez havendo risco desangramento, torna-se necessário o conhecimento do dilema Cirurgião x Testemunha de Jeová, visando o respeito às normas e resoluções vigentes e oportunizando umtratamento adequado para o paciente nesta situação peculiar.
Entre filtros e bolhas
Authors: Santana Ramon Davi , Neves Barbara Coelho
Published: March 2022

Aborda a modulação algorítmica e sua relação com a mediação da informação e o processo de filtragem da informação a partir do efeito “filtro-bolha”. Tem como objetivos discutir a informação no contexto da sociedade algoritimizada; debater a vigilância, o monitoramento e a filtragem da informação; e destacar a modulação algorítmica e a mediação da informação. A abordagem é qualitativa e utiliza a pesquisa bibliográfica sobre a temática proposta e a observação direta junto às plataformas digitais que fazem uso de filtragem. Como resultado, este artigo apresenta uma revisão dos principais conceitos que norteiam a filtragem da informação com o auxílio da modulação algorítmica. Conclui-se que a filtragem da informação e o “filtro-bolha” desenvolvem um ambiente controlado de informações mediante a propósitos escusos, gerando influências nos tecidos informacional, social, cultural e político da sociedade.
Analysis of Drug Repositioning and Prediction Techniques: A Concise
Review
Authors: He Shida , Liu Xin , Ye Xiucai , Tetsuya Sakurai
Published: March 2022

High costs and risks are common issues in traditional drug research and development. Usually, it takes a long time to research and develop a drug, the effects of which are limited to rela-tively few targets. At present, studies are aiming to identify unknown new uses for existing drugs. Drug repositioning enables drugs to be quickly launched into clinical practice at a low cost because they have undergone clinical safety testing during the development process, which can greatly re-duce costs and the risks of failed development. In addition to existing drugs with known indications, drugs that were shelved because of clinical trial failure can also be options for repositioning. In fact, many widely used drugs are identified via drug repositioning at present. This article reviews some popular research areas in the field of drug repositioning and briefly introduces the advantages and disadvantages of these methods, aiming to provide useful insights into future development in this field.
Main Fabrication Methods of Micellar Nanoparticles for Nanoscale Tumor
Therapy through the Self-assembly of Amphiphilic Copolymers
Authors: Jia Fan , Su Shishuai , Zhang Ruirui , Wu Yan
Published: March 2022

Micellar nanoparticles synthesized through the self-assembly of amphiphilic copolymers
have been widely used to encapsulate various cancer therapeutic agents for preclinical and clinical
applications. These drug delivery systems are easy to fabricate and have good biocompatibility in
general. In this article, we provide an overview of the advantages and disadvantages of micellar nanoparticles
for the fabrication of therapeutic agent-loaded nanoparticles from amphiphilic copolymers,
the examples of common polymer materials, and methods used to prepare micellar nanoparticles,
including emulsion solvent evaporation method, double emulsion method, nanoprecipitation
method, etc. By choosing an appropriate technique, different therapeutic agents with different properties
can be incorporated into nanoparticles individually or in combination. We analyzed the parameters
of various preparation methods, with particular emphasis on improvements in improved
techniques for simultaneous co-loading of hydrophilic/hydrophobic drugs and therapeutic nucleic
acids in a single nanoparticle. It will allow researchers to choose the appropriate method to design
therapeutic agent-loaded micellar nanoparticles from amphiphilic copolymers.
Methylated Barbituric Acid-Functionalized Tetraphenylethylene: Aggregation-
Induced Emission, Mechanochromism, and Optical Wave-Guiding
Properties
Authors: Ge Sheng , Xu Xiangjun , Xu Ziqiang , Wang Erjing , Li Dongqin , Wang Shimin
Published: March 2022

Background:

Restrained by the aggregation-causing quenching of conventional fluorophores,
the design and synthesis of solid-state emissive materials is a persistent pursuit for scientists.
The discovery of aggregation-induced emission provides an efficient strategy for preparing solidstate
emissive luminogens.

Objectives:

A multifunctional solid-state emissive material DMBTPE was prepared from tetraphenylethylene
and N-methylated barbituric acid through the construction of donor-acceptor structure.

Method:

DMBTPE showed typical aggregation–induced emission characteristics: non–emissive
when molecularly dissolved in solution while strongly emissive in the aggregated state or as solid.
Owing to the strong donor–acceptor interaction, the maximum absorption of DMBTPE shifted to
the visible light region. DMBTPE also exhibited reversible mechanochromic fluorescence with 30–
40 nm emission wavelength change.

Results:

DSC and XRD results indicated the transition between the amorphous state and crystalline
state was accounted for the mechanochromic fluorescence behavior. The microcrystalline rods of
DMBTPE grown from hot ethanol solution exhibited good optical waveguiding effect and the optical
loss was as low as 0.018 dB/μm.

Conclusions:

DMBTPE was an efficient solid emitter. Such attributes enable this kind of materials to
find wide applications in many areas, such as biological imaging and optoelectronic devices.
Thyroid homeostasis in obesity children
Authors: Sorokman T.V. , Popelyuk N.O.
Published: March 2022

Background. Due to the rapid increase in the prevalence of childhood obesity in Europe in recent years, various initiatives and actions have been launched in response to this alarming tendency. Over the last decade, the question of the interaction between obesity and thyroid pathology has been the most controversial. The study was aimed to assess the state of thyroid supply in overweight children. Materials and methods. Out of 936 people, 160 people aged 7 to 18 years with overweight (OW) and obesity were selected for a detailed study. The levels of thyroid-stimulating hormone (TSH), free triiodothyronine, and thyroxine (fT3, fT4) in serum were determined by enzyme-linked immunosorbent assay. Results. More than half of the children who were selected for the study had both diffuse nontoxic goiter (DNG) both in boys and girls (51.4%) with a predominance of thyroid volume corresponding to the first degree of goiter. Only in a small number of children with OW and obesity (14 out of 105 people, 13.3%), TSH levels were shifted toward its increase (4.31–4.98μIU/ml), and when using TSH/fT4, 20 (11.5%) children showed signs of laboratory hypothyroidism with a slight predominance of hyperthyrotropinemia in boys (18.5%) compared to girls (15.6%). The frequency of TSH levels >3.0μIU/ml elevated with increasing age of patients from 12.9% among children aged 7–9 years to 16.6% in the group of patients aged 10–13 years and 15.1% in children aged 14–18 years without significant differences by gender. Children with OW and obesity were more likely to have higher TSH values than children with DNG and normal body weight. Conclusions. Diffuse nontoxic goiter is more common in children with OW and obesity (51.2%) than in children with normal body weight (21.7%). The assessment of the age of the functional state of the thyroid gland in these children did not reveal significant changes in peripheral thyroid hormones, but in 11.5% of people, TSH/fT4 ranged from 0.19 to 0.29 and 13.3% of people had signs of subclinical hypothyroidism. This indicates the need to monitor the functional state of the thyroid gland in overweight and obese children.