bluuebunny/crossref_metadata_2025 huggingface dataset:
La transformación del pseudoevento en las redes sociales. El caso de #LaHoraMágica en Twitter/ The pseudo-event transformation in social networking sites. The case of #LaHoraMágica in Twitter
Authors: Caro Castaño Lucía
Published: August 2024

La integración de las redes sociales en el ecosistema mediático ha favorecido que técnicas promocionales y de relaciones públicas como el pseudoevento sean ahora adaptadas a las potencialidades de los nuevos medios. Este estudio exploratorio busca detectar los rasgos en común que mantiene la iniciativa #LaHoraMágica con la definición original del pseudoevento. #LaHoraMágica es una peculiar forma de agregado social que ha sido diariamente tendencia nacional en Twitter desde 2013 hasta principios de 2016. Para ello se emplea el estudio de caso, donde se ha combinado el análisis cualitativo con el estudio cuantitativo de uno de estos encuentros. Los resultados obtenidos muestran el claro predominio del modelo de emisión —sólo un 4,9% de respuestas (N=2.760)—. Asimismo, los datos apuntan hacia una finalidad autopromocional compartida por su organizador —como campaña de marca personal— y los participantes. #LaHoraMágica encarna así una nueva tendencia: el uso y transformación por parte de los usuarios del pseudoevento como una herramienta que ofrece el acceso a la visibilidad masiva online y en la que intervienen nuevos actores clave como los bots.
La importancia estratégica de la investigación preliminar de los públicos para los Departamentos de Comunicación de las empresas energéticas/ The strategic importance of the preliminary investigation of the Publics for the Departments of Communication
Authors: Capriotti Paul , Oliveira Andrea , Costa Lluís
Published: August 2024

Investigar los públicos es reconocido como un procedimiento crucial para que las organizaciones gestionen estratégicamente su comunicación con estos grupos. Sin embargo, aunque se otorgue una importancia fundamental al estudio de los públicos, la investigación de estos colectivos sigue siendo una cuestión no consolidada en la práctica profesional de la comunicación organizacional y las relaciones públicas. Este artículo busca analizar si las empresas realizan investigación de sus públicos claves y evaluar si existe coherencia entre la asignación de importancia a los públicos estratégicos y  la investigación de estos grupos por parte de las empresas del sector energético en España. Los resultados indican que las empresas realizan habitualmente investigación de sus públicos, pero no hay una correspondencia clara entre la importancia asignada a los públicos claves y el nivel de investigación implementada en los mismos.
Impeachment e imagem pública: uma análise do discurso vazado de Michel Temer / Impeachment and public image: an analysis of Michel Temer’s leaked speech
Authors: Nichols Bruno Washington , Pimentel Pedro Chapaval
Published: August 2024

Resumo Em meio à conturbada conjuntura política brasileira pós-2014, esta pesquisa realiza uma análise da construção de imagem pública realizada pelo então vice-presidente da República, Michel Temer. O corpus de análise é um áudio contendo um hipotético discurso vazado à imprensa, que versa sobre os desafios do país em seu eventual mandato. Com base na análise qualitativa de auditórios e técnicas argumentativas propostas por Perelman e Olbrechts-Tyteca (2014), avaliamos a hipótese de que Temer tenta descolar sua imagem pública daquela do governo de Dilma Rousseff. Palavras chave: Comunicação Política; Construção de Imagem Pública; Impeachment; Michel Temer; Brasil. Abstract Amid the turbulent Brazilian political conjuncture post-2014, this research analyzes the public image building carried out by the vice-president, Michel Temer. The sample analyzed is an audio of a hypothetical speech which was leaked to the press and deals with the country’s challenges that would be faced by his eventual mandate. Based on the qualitative analysis of auditoriums and argumentative techniques proposed by Perelman and Olbrechts-Tyteca (2014), we evaluated the hypothesis that Temer tries to detach his public image from that of Dilma Rousseff’s government. Keywords: Political Communication; Public Image Building; Impeachment; Michel Temer; Brazil.
Apontamentos críticos dos modelos de Relações Públicas excelentes no maior acidente ambiental do Brasil/Critical notes of excellent Public Relations models in Brazil's biggest environmental disaster
Authors: Lima Fábia Pereira
Published: August 2024

O presente artigo tem como objetivo refletir de maneira crítica sobre o modelo ideal normativo hegemônico das Relações Públicas, o simétrico de mão dupla, proposto por Grunig e Hunt (1984), buscando observar em que medida tal modelo tem sido utilizado para legitimar ações de comunicação organizacional de uma empresa de mineração atuante no Estado de Minas Gerais, escamoteando as forças persuasivas, as assimetrias e os jogos de coerção que fazem parte de suas práticas. Como objeto empírico será utilizado o caso do maior acidente ambiental do Brasil, originado com o rompimento de uma das barragens de rejeitos (Fundão) da Samarco Mineração S.A., ocorrido em 5 de novembro de 2015 no município de Mariana, Estado de Minas Gerais. Este acontecimento afetou uma enorme região às margens do Rio Doce, ocasionando impactos pessoais, sociais, ambientais e econômicos, evidenciando questões fundamentais à prática das Relações Públicas e da comunicação no contexto organizacional contemporâneo.
Docência em Relações Públicas: fragmentos de uma reflexão inacabada/ Teaching Public Relations: fragments of an unfinished reflection
Authors: Andrade Scroferneker Cleusa Maria , Corte Vitória Maria Inês
Published: August 2024

O presente artigo propõe discutir, mesmo que brevemente, sobre a necessidade de (re) pensar as Relações Públicas a partir dos novos cenários que se desenham e que passam a demandar profissionais de comunicação críticos e reflexivos, com competências para além do ‘fazer’. Trata-se em realidade de uma discussão antiga, mas que entendemos oportuna face à implantação das Diretrizes Curriculares que definiram a ‘separação’ (grifo nosso) dos Cursos de Relações Públicas, Jornalismo, Publicidade e Propaganda e que tendem, sob nossa perspectiva, à criação de ‘reservas de mercado’ em tempos em que o conhecimento não tem fronteiras.
Presentación: Docencia en Relaciones Públicas en Brasil - Ensino em Relações Públicas no Brasil / Presentation: Teaching in Public Relations in Brazil
Authors: ALMANSA-MARTÍNEZ ANA
Published: August 2024

Presentación del número, a cargo de la coordinadora, la Dra.Cleusa Maria Andrade Scroferneker.
Turismo y desarrollo socio-económico local: la aplicación de técnicas de relaciones públicas como estrategia de gestión y promoción turística/Tourism and local socio-economic development: the application of public relations techniques as a strategy
Authors: Pérez-García Antonia
Published: August 2024

El objetivo de este artículo es presentar el estudio que permitió identificar las técnicas de relaciones públicas que aplican los Agentes de Desarrollo Local (ADL), así como su conocimiento sobre dichas técnicas, en el proceso de gestionar y promocionar actividades turísticas locales en los municipios que componen la provincia de A Coruña. En general se puede concluir que los Agentes de Desarrollo Local vienen utilizando algunas de las técnicas de relaciones públicas Transversales, de Relación con la Comunidad y de Relación con los Medios de Comunicación, que demuestran la importancia del papel de las relaciones públicas como estrategia informativo-comunicativa relacional, en el ámbito del desarrollo socio-económico local para potenciar y promocionar el turismo.Palabras clave: desarrollo socio-económico local, turismo, técnicas de relaciones públicas. Abstract This article presents the study that allowed for the identification of the public relations techniques applied by Local Development Agents (LDA) and their degree of awareness of them when managing and promoting local tourism activities designed to post the economic and social conditions of the municipalities of A Coruña. The results of the study reveal a general trend amongst LDA towards the use of public relations transversal techniques targeting relations with the community and the media, highlighting the key role played by public relations as a relational information-communication strategy within the sphere of local socio-economic development for boosting and promoting tourism. Keywords: local socio-economic development, tourism, public relations techniques
La escucha organizacional como estrategia de comunicación. Análisis de su gestión en España/ The organizational listening as a communication strategy. Analysis of its management in Spain
Authors: Moreno Ángeles , Khalil Nadia , Gómez María del Pilar
Published: August 2024

Este artículo analiza el uso de la escucha organizacional como estrategia de comunicación por parte de las organizaciones en España. Pese a su relevancia, la escucha organizacional no es una estrategia muy estudiada. Queremos saber si las organizaciones españolas priorizan e incorporan técnicas y estrategias de relaciones públicas en función de la escucha, así como la implementación de las mismas. Para ello, se sigue una metodología cuantitativa con el uso de encuestas a comunicadores y stakeholders de organizaciones españolas. Los resultados indican, por una parte, que las empresas en España aplican esta estrategia en menor medida que otro tipo de estrategias de comunicación y, por otra, que los públicos perciben que las organizaciones hacen un uso utilitarista de la escucha en su propio beneficio.Palabras clave: escucha organizacional, estrategias de comunicación, relaciones públicas, gestión de la comunicación. Abstract This paper analyses the use of organizational listening as a communication strategy for organizations in Spain. Despite its relevance, organizational listening is not much studied. We want to know if Spanish organizations give priority and incorporate techniques and strategies of public relations according to the listening, and also about their implementation. For that purpose, a quantitative methodology is applied using surveys to communication practitioners and stakeholders of Spanish organizations. Results show that, on the one hand, organizations in Spain apply this strategy to a lesser extent than other types of communication strategies, and, on the other hand, stakeholders perceive that organizations make a utilitarian use of the organizational listening techniques for their own benefit. Keywords: organizational listening, communication strategies, public relations, communication management.
Processing Business Analysis Belida Fish (Notopterus chitala) and Patin Fish (Pangasius sp) in Jantur Village Muara Muntai District Kutai Kartanegara District
Authors: Novia Novia , Saleha Qoriah , Erwiantono Erwiantono
Published: August 2024

This study aims to determine the stages of processing crackers and amplang from belida fish and patin fish in Jantur Village, Muara Muntai Subdistrict by analyzing the feasibility of businesses run by 8 respondents. The research method used is qualitative and quantitative, using a questionnaire to conduct structured interviews.  Data sample collection was carried out using the census and survey methods and then analyzed descriptively and calculated the sales costs and profits of processed belida and catfish businesses. The processing cycle of belida fish crackers, amplang belida fish, and catfish crackers is 1-6 times/production year (average 3 production cycles/year). The average profit obtained from the belida fish cracker processing business is Rp.1,042,234 / year. The average profit obtained from the belida fish amplang processing business is Rp.2,744,869 / year and the average profit obtained from the patin fish cracker processing business is Rp.59,133 / year. This business feasibility analysis results show that processing belida fish and catfish is still often run even though it takes longer to reach the return on investment.
Fast Spin Echo Approach for Accelerated B1-gradient Based MRI
Authors: Froelich Taylor , DelaBarre Lance , Wang Paul , Radder Jerahmie , Torres Efrain , Garwood Michael
Published: August 2024

Recent efforts to expand access to MRI have focused on low-cost, portable MRI systems that eliminate pulsed B0 gradients in favor of radio-frequency imaging techniques. In this work we present a new multi-echo version of FREE (Frequency-modulated Rabi Encoded Echoes) that utilizes nonlinear B1+ gradients to perform spatial encoding. This new technique leverages the acceleration of conventional FSE approaches and nonlinear gradients to eliminate the need for conventional B0 gradients while also achieving very high spatial resolution.
Quantification of Blood-Brain Barrier Water Exchange & Permeability with Multi-Delay Diffusion Weighted pCASL
Authors: Shao Xingfeng , Zhao Chenyang , Shou Qinyang , Lawrence Keith St , Wang Danny
Published: August 2024

We developed an innovate pulse sequence and acquired diffusion weighted pCASL signals from a wide range of PLDs with improved SNR and spatial resolution. A 3-compartment single-pass approximation (SPA) model, which includes an additional venous compartment, was proposed to capture the full dynamics of the labeled blood bolus passing through capillaries while exchanging into tissue space before flowing into venules, and a LRL method was proposed for individual kw quantification.
Reproducibility of non-invasive 3D imaging of glucose downstream metabolism using deuterium labeling: indirect 1H QELT at 3T vs direct 2H DMI at 7T
Authors: Niess Fabian , Hingerl Lukas , Strasser Bernhard , Bednarik Petr , Goranovic Dario , Niess Eva , Motyka Stanislav , Hangel Gilbert , Krssak Martin , Spurny-Dworak Benjamin , Scherer Thomas , Lanzenberger Rupert , Bogner Wolfgang
Published: August 2024

Deuterium metabolic imaging (DMI) and quantitative exchange label turnover (QELT) are emerging MR techniques to non-invasively map brain glucose uptake and downstream metabolism using safe and affordable deuterium labeled glucose as tracer. This work compares dynamically detected deuterium labeled Glutamate+Glutamine time courses between three-dimensional 3T-1H QELT-MRSI and 7T-2H-DMI using quantification of concentration estimates. Comparable enrichment of deuterated Glx could be observed in gray matter (1.59±0.24mM vs. 1.39±0.17mM) while differences were found in WM (0.89±0.32 mM vs. 1.31±0.2 mM) presumably due to partial volume contamination. Results showed a successful translation of QELT to clinical 3T.
Expanding interleaved MRI-DMI to 3D SWI (Susceptibility Weighted Imaging) : A truncated acquisition approach
Authors: Liu Yanning , Corbin Zachary , Fulbright Robert , Nixon Terry , McIntyre Scott , De Feyter Henk , de Graaf Robin
Published: August 2024

Interleaved MRI-DMI (Deuterium Metabolic Imaging) is a transformative approach to obtain multi-contrast anatomic MRI and metabolic information in parallel with time efficiency. In this work, we expand the toolkit of interleaving 2H DMI with 1H MRI, by using a newly developed interleaved 3D SWI-DMI sequence that relies on acquiring a truncated 2H signal. Acknowledging the limitations of fitting truncated 2H signals independently, we propose a method to combine truncated FID with fully-sampled acquisitions to improve DMI sensitivity. The updated interleaved MRI-DMI protocol with 3D SWI-DMI was demonstrated on a patient with a brain tumor.
Estimation of pH values and magnesium ion content in vivo using a chemical shift dictionary for 31P MRSI at UHF
Authors: Franke Vanessa L. , Breitling Johannes S. , Bangert Renate , Boyd Philip S. , Weckesser Nina , Schlemmer Heinz-Peter , Paech Daniel , Ladd Mark E. , Bachert Peter , Korzowski Andreas
Published: August 2024

31P MRSI enables non-invasive mapping of pH value and magnesium content in vivo, and is conventionally done by calibration equations, like the modified Henderson-Hasselbalch equation, relating 31P chemical shifts to physiological parameters. The reliability of this approach might be hampered when applied to diseased tissue, like cancer, where the chemical conditions are altered. Recently, we proposed a chemical shift dictionary for 31P MRSI to potentially enable a condition-independent estimation of pH value and magnesium content. In this study, the applicability of this approach to in vivo data is tested, and its potential for further research identified.
Iron accumulation and MRI iron contrast are not driven by amyloid plaques in posterior cortical atrophy
Authors: Kirilina Evgeniya , Edwards Luke , Jäger Carsten , Reinert Tilo , Jauch Anna , Brammerloh Malte , Herrmann Karl-Heinz , Scheibe Patrick , Büttner Felix , Brückner Dennis , Falkenberg Gerald , Reichenbach Jürgen , Weiskopf Nikolaus
Published: August 2024

We combined ultra-high resolution quantitative MRI, X-ray fluorescence, and biophysical modeling to study iron-induced MRI contrast in the visual cortex of patients with Alzheimer’s disease (AD) and its variant posterior cortical atrophy (PCA). The iron content of amyloid plaques in patients with PCA and AD exceeded the iron concentration in the surrounding tissue by less than 15%, constituting only a minor contribution to the intracortical T2* contrast. The elevated levels of brain iron detected by iron-sensitive MRI contrasts are not indicative of plaques but may reflect other processes, such as inflammation or leakage in the blood-brain barrier.
Optimization of the T2-weighted MRI contrast in 0-6-month-old infant brain based on extended phase graph theory
Authors: Wu Jiani , Zhang Hongxi , Li Haotian , Wang Siyifei , Yong Xingwang , Wu Dan
Published: August 2024

3D T2-weighted MRI using fast spin-echo (FSE) with variable flip angles has been widely for anatomical imaging. However, 3D FSE of infant brains exhibits poor contrast due to the inherently close and rapidly changing T2 relaxation times between white matter and grey matter. Here we proposed an extended-phase-graph-based method to optimize the flip angles in FSE sequence for maximizing the white/grey matter contrast in 0 to 6 month-old infant brains at 3T, based on T2 values acquired from 37 infant brains. Results demonstrated improved relative contrasts in infant brains by 1.6-2 folds at different ages in different regions of interest.
Free-breathing Simultaneous T1, T2, and T2* Mapping of the Whole-Liver with Multi-Inversion Spin and Gradient Echo in Under a Minute
Authors: Manhard Mary Kate , Ramaniharan Anandh Kilpattu , Tkach Jean , Trout Andrew , Dillman Jonathan , Pednekar Amol
Published: August 2024

Quantitative parametric mapping is an increasingly important tool for non-invasive assessment of liver disease. Conventional parametric mapping techniques require multiple breath-held acquisitions providing limited coverage. A free-breathing multi-inversion spin and gradient echo (MI-SAGE) technique is demonstrated to simultaneously estimate T1, T2, and T2* over the whole-liver in a single scan of less than 1 minute. In 11 research participants, hepatic T1, T2, and T2* estimates obtained using the free-breathing MI-SAGE technique were comparable to those obtained using modified Lock Locker, multiple gradient and spin echo, and multiple gradient echo sequences respectively and exhibited good to excellent (ICC>0.77) repeatability and reproducibility.
Assessment of Inflammation and Spatial Heterogeneity for Nonalcoholic Fatty Liver Disease in Mice Based on Corrected T1
Authors: Li Lujie , Deng Kan , Zhang Yinhong , Feng Shi-ting
Published: August 2024

Corrected T1 (cT1) is potential to be a novel imaging biomarker, which was based on T1 mapping corrected for iron content. The results of this study showed the high correlation between cT1 value and NAFLD activity, without correlation with fibrosis. There was high accuracy of cT1 to identify normal liver and liver with NAFLD, as well as mild and severe NAFLD. The severer inflammation, the higher heterogeneity of cT1 mapping. Thus, cT1 may be used for evaluating liver inflammation of patient with NAFLD, especially for those without severe fibrosis, and may evaluate heterogeneity further.
Longitudinal MR Elastography and Proton Density Fat Fraction Measurements in Patients with Alcoholic and Nonalcoholic Fatty Liver Disease
Authors: Li Jiahui , Zhu Zheng , Glaser Kevin , Sui Yi , Simonetto Douglas , Allen Alina , Manduca Armando , Venkatesh Sudhakar , Shah Vijay , Ehman Richard , Yin Meng
Published: August 2024

To evaluate MR imaging biomarkers in monitoring chronic liver diseases, we analyzed longitudinal MRE-assessed liver stiffness (LS) and proton density fat fraction (PDFF) measurements in 46 patients with alcoholic liver disease (ALD) or nonalcoholic fatty liver disease (NAFLD). Results demonstrated that yearly LS change rate was significantly associated with current LS and PDFF change rate in NAFLD, although with low correlation (R2=0.30, p=0.01). ALD patients had bidirectional changes in LS/PDFF change rate but not significant correlation (R2=0.20, p=0.10). We conclude that longitudinal MRE-LS and MRI-PDFF provide independent and complementary assessments of disease status and dynamic change in ALD and NAFLD.
Anatomically Accurate In vitro Model of the Liver for 4D Flow MRI Validation
Authors: Rice James , Oechtering Thekla , Johnson Kevin , Wieben Oliver , Reeder Scott , Roldan-Alzate Alejandro
Published: August 2024

4D flow MRI can be used to assess hemodynamics in the hepatic circulation system. This study presents a framework for in vitro hemodynamic evaluation of hepatic flow. One patient-specific in vitro model was created representing an anatomically realistic portal vein and hepatic artery and connected to a physiologic flow loop. The model was imaged with 4D flow MRI to assess hemodynamics. Altering hepatic artery and left gastric vein resistance changed flow proportions and velocities in the portal vein, highlighting the benefit of using in vitro modeling for systematic evaluation of 4D flow MRI in the liver.
Intravoxel incoherent motion DWI with different mathematical models in predicting rectal adenoma with and without canceration
Authors: Yuping Jia , Weiqiang Dou
Published: August 2024

This study aimed to use intravoxel incoherent motion (IVIM) DWI with different mathematical models to predict rectal adenomas with and without canceration. The parameters of different IVIM-DWI models, including apparent diffusion coefficient (ADC) from mono-exponential model, true diffusion coefficient, pseudo-diffusion coefficient and perfusion fraction from bi-exponential model, and the distributed diffusion coefficient and water molecular diffusion heterogeneity index from stretched-exponential model were compared between 31 adenoma and 29 adenoma with canceration. We found that mono-exponential derived ADC can easily predict rectal adenomas with canceration, and bi-exponential model has a better combination of sensitivity and specificity for diagnosing rectal adenoma canceration.
The joint registration of multiple microscopy contrasts to MRI in the BigMac dataset
Authors: Huszar Istvan , Zhu Silei , Smart Adele , Jbabdi Saad , Miller Karla , Howard Amy
Published: August 2024

We built a novel pipeline to register 290 high-resolution multi-contrast microscopy sections in the BigMac dataset to post-mortem MRI with sub-millimetre accuracy. The MRI-microscopy alignment is optimised over all microscopy sections jointly, to achieve high-quality co-registration whilst ensuring the slide order and separation is consistent with how the tissue was sectioned. We demonstrate the accuracy of the registration by overlaying FreeSurfer-estimated grey-white matter contours on orthogonal sections of 3D volumetric reconstructions of each microscopy modality. Our pipeline provides an integrated workflow for diffusion-microscopy studies using the BigMac dataset, which is openly available via the Oxford Digital Brain Bank.
Characterization of the R2*/R2 ratio of the BOLD laminar-specificity through biophysical simulations using realistic vascular architectures
Authors: Báez-Yáñez Mario Gilberto , Curcic Vanja , Siero Jeroen , van Osch Matthias J.P. , Petridou Natalia
Published: August 2024

GE-BOLD fMRI is the most used technique to measure functional hyperemia across cortical depth. GE-BOLD is sensitive towards all vascular contributions, while SE-BOLD increases the specificity towards small vessels– being more specific to neuronal activity. However, SE-BOLD fMRI measurements may not completely remove the macrovascular contribution. Using realistic vascular models, we simulated specific oxygenation states in different vascular compartments to characterize the GE-and SE-BOLD specificity across cortical depth quantified through the R2*/R2-ratio. Simulations show 1)similar ratio values at deeper layers indicating comparable specificity to microvessels for both sequences, 2)layer-fMRI SE-BOLD cannot completely eliminate the macrovascular contribution towards the pial surface.
Effects of Levodopa Therapy on Neurovascular Coupling in Parkinson’s Disease Patients
Authors: Wu Chenqing , Wu Haoting , Zhou Cheng , Chen Jingwen , Wen Jiaqi , Liu Xiaocao , Qin Jianmei , Cao Zhengye , Guo Tao , Guan Xiaojun , Xu Xiaojun , Zhang Baorong , Zhang Minming
Published: August 2024

Abnormal neurovascular coupling was found in PD patients. These impairments were partially normalized after levodopa therapy, and ALFF alterations played a primary role in this normalization effect.
Clinically Feasible Patient-Specific Targeting Method for Improved Quality-of-Life Outcomes from MRgFUS Treatment of Essential Tremor
Authors: Datta Anjali , Kung Gustavo Chau Loo , Quah Kristin , Barbosa Daniel , Li Chelsea , Purger David , Wang Allan , Chodakiewitz Yosefi , Ghanouni Pejman , Buch Vivek , McNab Jennifer
Published: August 2024

MRI-guided focused-ultrasound (MRgFUS) is an FDA-approved treatment for essential tremor. Unfortunately, the target to be ablated cannot be directly visualized on standard imaging, and its location varies interindividually. Since suboptimal lesion location can lead to side effects that impair quality of life, a method that locates personalized ablative targets that correlate with better quality-of-life outcomes (and not just with tremor reduction) could provide significant benefit. We present a clinically-feasible patient-specific probabilistic-tractography-based method for personalized targeting of MRgFUS treatment and show that similarity between the target it generates and the ablated lesion predicts QoL outcome in a dataset of 36 patients.
T2* assessment of neoadjuvant radiation therapy combined with pharmacological ascorbate in extremity soft-tissue sarcomas: a pilot study
Authors: Lee Chu-Yu , Petronek Michael , Monga Varun , Miller Benjamin , Milhem Mohammed , Magnotta Vincent , Allen Bryan
Published: August 2024

Soft-tissue sarcomas is commonly treated by neoadjuvant radiation therapy followed by surgical resection. Current assessment of neoadjuvant therapy relies on pathological examinations after surgery. Nonetheless, noninvasive imaging assessment can be performed before and during the treatment, offering the opportunity for predicting and early assessing treatment response. This pilot study applied T2* mapping to evaluate neoadjuvant therapy in seven patients with soft-tissue sarcomas before, during the treatment, and before surgery. The results showed strong or moderate correlations between T2* measurements and percent necrosis from pathological examinations, suggesting the potential for using T2* mapping to predict and early assess treatment response.
Feasibility study of diusion weighted imaging of nasopharynx using split-echo TSE-DWI combined with MultiVane acquisition
Authors: Wang Kun , Yu Yujie , Wang Maoxue , Li Ming , Zhao Xiance , Wu Peng , Deng Kan
Published: August 2024

Diusion weighted imaging (DWI) has high sensitivity in the dierential diagnosis of nasopharyngeal carcinoma. However,the DWI based on SE-EPI has poor imaging quality in the nasopharynx. A combination of Multi-Vane (MV) and SPLICE(MV-SPLICE) were developed to reduce ELT, as well as improve SNR and the imaging quality of DWI. This study compares theDWI images of three acquisition sequences in nasopharynx,including DWI TSE without SPLICE(TSE), TSE with SPLICE(TSE-XD), and TSE with MV-SPICE(TSE-XD-MV) and proves that TSE with MV-SPLICE DWI based TSE with MV-SPLICE provides anexcellence imaging scheme of DWI for the clinical diagnosis of nasopharyngeal diseases.
In-Vivo CEST MRI to assess and identify myocardial infarction by using natural D- glucose as a contrast agent
Authors: Peddi Ajay , Schache Daniel , Nahardani Ali , Kuhlmann Michael , Wildgruber Moritz , Faber Cornelius , Hoerr Verena
Published: August 2024

The current preclinical study aimed to explore the application of natural D-glucose as an infusible biodegradable MRI contrast agent for imaging of myocardial infarction (MI) by glucose weighted CEST MRI (glucoCEST). To this end, in a mouse model of MI, the infarct region was first identified and verified by late gadolinium enhancement MRI and histology, respectively. In-Vivo glucoCEST MTRasym maps showed substantial differences before and after glucose infusion according to the myocardial viability. Statistical analysis verified that glucoCEST contrast could distinguish significantly between MI region, remote myocardium as well as healthy myocardium.
Non-invasive magnetic resonance imaging agent for in-vivo nitric oxide activity detection
Authors: Hong Anlan , Vollett Kyle , Troy Aaron , Cheng Hai-Ling
Published: August 2024

We report a novel nitric oxide (NO)-sensitive MRI contrast agent that holds potential for detecting endogenous NO. Type I collagen and HEK cell lysate showed strong binding with NO agent, while HSA and various ROS/RNS species showed NO agent was only activated by NO. In vivo washout rate was also tested, and NO agent cleared from mice 7 days after intraperitoneal injection. Prolonged enhancement was observed in the heart after isoproterenol injection, which indicated excess NO production and inflammation. The NO agent shows promise as a molecular imaging agent in early detection of inflammatory diseases.
Quantification of abnormal metabolism in hypertrophic cardiomyopathy patients using hyperpolarized [1-13C]-pyruvate MRI
Authors: Sinha Avantika , Liu Xiaoxi , Tang Shuyu , Dwork Nicholas , Sivalokanathan Sanjay , Liu Jing , Bok Robert , Ordovas Karen , Slater James , Gordon Jeremy , Abraham M , Larson Peder
Published: August 2024

Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy with a worldwide prevalence of ~1:250. It is the leading cause of sudden cardiac death often during exercise and in otherwise healthy, young individuals. We applied hyperpolarized [1-13C]-pyruvate MRI for metabolic imaging to 3 patients with HCM using multi-slice, dynamic metabolite-specific imaging with autonomous scanning. We observed focal metabolic abnormalities corresponding to regions of hypertrophy in patients with asymmetric non-obstructive HCM and differences in metabolism measurements compared to healthy volunteers.
Automated detection and quantification of myocardial scar using AI-powered joint bright- and black-blood LGE imaging
Authors: Bustin Aurelien , Ribal Indra , Montier Géraldine , Maes Jean-David , Boullé Thibault , de Villedon de Naide Victor , Gut Pauline , Sridi Soumaya , Ozenne Valery , Nuñez-Garcia Marta , Sermesant Maxime , Montaudon Michel , Dournes Gäel , Laurent François , Jaïs Pierre , Stuber Matthias , Cochet Hubert
Published: August 2024

Bright-blood late gadolinium-enhanced (LGE) imaging is the current clinical gold standard to assess myocardial scar. However, poor contrast at the blood-scar interface makes scar detection and quantification challenging. Bright- and black-blood LGE imaging technologies have recently enabled more accurate scar detection and localization and have shown promising results for scar quantification. Here we aim to introduce a framework for fully automated scar detection and quantification combining novel joint bright- and black-blood LGE imaging with artificial intelligence-powered analysis.
Free-Breathing Simultaneous Native Myocardial T1, T2, and T1ρ Mapping with Cartesian Acquisition and Dictionary Matching
Authors: Lv Zhenfeng , Hua Sha , Guo Rui , Shi Bowen , Hu Peng , Qi Haikun
Published: August 2024

T1 and T2 are well-recognized parameters for detecting various cardiomyopathies, and T1ρ is an endogenous contrast for myocardial fibrosis. Multi-parametric cardiac MRI can provide co-registered parameter maps for comprehensive diagnosis and account for the interparameter dependency for more accurate quantification. Therefore, we propose a free-breathing simultaneous T1, T2, and T1ρ mapping technique with single-shot Cartesian acquisition and dictionary matching for parameter quantification. The phantoms results indicated the good accuracy and insensitiveness to heart rates of the proposed technique. Using prospective through-plane and retrospective in-plane motion correction, the proposed method generated similar in vivo mapping quality to breath-hold mapping methods.
Screening abbreviated breast MRI with ultrafast imaging: prospective study results
Authors: Pineda Federico , Ren Zhen , Safi Rabia , Hill Elle , Kulkarki Kirti , Abe Hiroyuki , Karczmar Gregory
Published: August 2024

We report on the results of a prospective screening trial using abbreviated breast MRI with ultrafast dynamic contrast-enhanced imaging (3.5 seconds per time point) to screen for breast cancer in 166 women at any risk of developing breast cancer. The cancer detection rate was 24.1 per 1000 women while maintaining a specificity of 97.6%. The biopsy recommendation and abnormal interpretation rates were lower than in other published trials that did not include ultrafast imaging in their abbreviated protocol.
A panoramic view for supine breast MRI
Authors: Nohava Lena , Obermann Michael , Laistler Elmar
Published: August 2024

A wearable coil worn like a vest (“BraCoil”) has recently been shown to improve signal-to-noise ratio by a factor of up to three in supine breast MRI. However, the visualization of supine breast images is inefficient when using Cartesian views due to the bent shape of the breast along the chest wall. We introduce a panoramic view similar to panoramic dental X-ray to make reading of supine breast MRI more efficient by reducing the number of slices by a factor of 2-4, depending on breast size.
In vivo CEST-Dixon MRI in axillary lymph nodes with and without carcinoma: potential for noninvasive determination of lymph node metastasis
Authors: Crescenzi Rachelle , Donahue Paula , Jones R. Sky , Lee Chelsea , Garza Maria , Patel Niral , Meszoely Ingrid , Donahue Manus
Published: August 2024

The overall goal of this work is to apply a CEST-Dixon MRI approach in the axillary lymph nodes (LNs) of women with breast cancer to test fundamental hypotheses about biochemical LN profiles with carcinoma. Mean z-spectra and corresponding significant differences in cohorts with metastatic vs. benign LNs were observed in regions of known chemical exchange for the nuclear Overhauser effect (PTR=0.087 vs. 0.051, p=0.04), hydroxyl (PTR=0.272 vs. 0.212, p=0.003), and amine (PTR=0.081 vs. 0.033, p=0.003) protons. CEST-Dixon MRI of LNs may have relevance for pre-surgical breast cancer staging and for guiding LN sparing resections to reduce risk for lymphedema.
Assessment of Breast Lesions by the Kaiser Score for Differential Diagnosis on MRI: The Added Value of ADC and Machine Learning Modeling
Authors: Chen Zhong-Wei , Zhao You-Fan , Liu Hui-Ru , Zhou Jie-Jie , Miao Hai-Wei , Ye Shu-Xin , He Yun , Liu Xin-Miao , Su Min-Ying , Wang Mei-Hao
Published: August 2024

How ADC could be combined with Kaiser score (KS) for the diagnosis of breast cancer was emerged as an interesting research area. We modified KS to KS+ based on the dichotomized ADC >1.4×10-3 mm2/s, and integrated KS and the continuous ADC values to build machine learning (ML) models for assessment. The diagnostic specificity of KS+ was higher than that of KS with a slightly degraded sensitivity. The AUCs of them were not significantly different. When the KS and the continuous ADC values were used to train ML models, the performance could be further improved while maintaining at a high sensitivity.
A Versatile Toolbox for Rapid, Joint Design of pTx RF and Gradient Pulses Using Pytorch's Autodifferentiation
Authors: Bosch Dario , Bause Jonas , Scheffler Klaus
Published: August 2024

Traditional pTx pulse design focuses on optimizing RF pulses with a fixed or parametrized gradient waveform. Utilizing fast GPUs for autodifferentiation, the optimization process becomes sufficiently efficient that RF pulses and the underlying gradient waveforms can be freely optimized concurrently within short time. This allows for the time-efficient creation of pTx pulses without prior knowledge about suitable gradient trajectories. Still, restrictions e.g. due to hardware limitations may be included into the optimization process. We provide a pulse design toolbox and demonstrate its ability to generate universal small-FA excitation pulses as well as large-FA pulses.
Combined triple tuned X-nuclei (2H, 23Na, 31P) birdcage and 1H 4 channel dipole array for head imaging at 7T
Authors: Paska Jan , Wang Bili , Chen Anna , Madelin Guillame , Brown Ryan
Published: August 2024

One method to achieve multiple coil resonances involves the use of diode or microelectromechanical system (MEMS) switches to toggle between resonances at proton and x-nuclei frequencies. While this approach provides a straightforward means to activate or deactivate coils corresponding to the desired nucleus, it does not allow simultaneous multinuclear data acquisition hat is required to eliminate temporal disparities. In this work we present a triple tuned birdcage for truly simultaneous imaging of X-nuclei combined with a proton dipole array at 7T. We show initial phantom imaging experiments and compare SNR with existing RF coils.
Mapping functional connectivity of insular subdivisions using connectivity-based parcellation in adolescents with major depressive disorder
Authors: Zhou Zilin , Cao Lingxiao , Gao Yingxue , Feng Ruohan , Li Yang , Bao Weijie , Liang Kaili , Zhuo Lihua , Huang Guoping , Huang Xiaoqi
Published: August 2024

Using a data-driven connectivity-based parcellation technique, we identified anterior and posterior functional subdivisions of insula per hemisphere in adolescent population based on their similar functional connectivity profiles. Then, we investigated the distinct functional connectivity of each insular subregion between depressive adolescents and typical developmental controls. The significant unbalanced connectivity of insular subregions with left superior frontal gyrus (SFG) between two groups was revealed, which associated with interpersonal relation, emotional expressiveness, and cognition impairments in depressive adolescents. Our findings indicate that abnormalities in functional architectures of insular subdivisions may be the potential neuroimaging mechanism underlie the specific manifestations in adolescent depression.
Ultrafast multi-parametric quantitative MRI using Multi-TR echo-planar time-resolved imaging (Multi-TR-EPTI)
Authors: Bai Haoran , Qiu Yueqi , Dai Ke , Chen Hao , Zhang Zhiyong
Published: August 2024

Echo planar time-resolved imaging (EPTI) is a recently developed multi-shot EPI method that provides time-resolved multi-echo images and providing multi-contrast images. Based on this basis, here we present Multi-TR-EPTI, a technique developed to achieve distortion-free and Multi-parametric quantitative MRI including T1, T2, T2*, and PD mapping. Multi-TR-EPTI exploits an optimized spatiotemporal CAIPI encoding in the k-TE-TR space.which can recover the k-TE-TR space within the same shot number as the original EPTI. A subspace reconstruction was employed to obtain hundreds of high-quality multi-contrast images at sub-millisecond temporal increments. Multi-TR-EPTI adopts different TRs to provide T1 contrast while improving scan efficiency.
Alternating Look-Locker for 3D quantitative longitudinal and rotating frame relaxation mapping
Authors: WU Lin , Carchi Chris , Michaeli Shalom , Mangia Silvia , Idiyatullin Djaudat
Published: August 2024

A new method entitled alternating Look-Locker (aLL) for mapping of T1 and T1ρ is proposed. Magnetization preparation modules incorporating adiabatic full passage pulses were imbedded in a Look-Locker scheme that additionally alternates magnetization from +Z and -Z axes. MB-SWIFT was used as a readout. Analytical derivations and relevant simulations are presented. Phantom experiments and in vivo studies in the rat brain were conducted at 9.4 T. Results show that aLL allows more robust and faster acquisitions as compared to previously introduced steady–state technique, providing the possibility of simultaneous collection of T1 and T1ρ maps in one acquisition.
Comparison of radio-pathomic maps of tumor probability to 5-ALA guided surgical resection cavities in glioblastoma patients
Authors: Bobholz Samuel , Lowman Allison , Duenweg Savannah , Winiarz Aleksandra , Stebbins Margaret , Kyereme Fitzgerald , Connelly Jennifer , Coss Dylan , Mueller Wade , Agarwal Mohit , Banerjee Anjishnu , Krucoff Max , LaViolette Peter
Published: August 2024

This study sought to compare previously published autopsy-based radio-pathomic maps of pre-surgical cellularity and tumor probability to beyond-contrast 5-ALA guided resection margins to assess concordance in identifying non-enhancing tumor between the techniques. In a series of 10 cases, radio-pathomic maps were able to identify areas of non-enhancing tumor prior to surgery that coincided with either 5-ALA guided resection margins or areas of future recurrence in 7 of 10 cases, suggesting that highlighted areas on these maps indicate active, progressive tumor.
Neurite orientation dispersion and density MR imaging: discriminating atypical high-grade glioma from primary central nervous system lymphoma
Authors: Gao Eryuan , Zhao Guohua , Zhang Huiting , Wang Peipei , MA Xiaoyue , Bai Jie , Yan Xu , Yang Guang , Cheng Jingliang
Published: August 2024

Preoperative differentiation of atypical high-grade glioma (HGG) (with no or little necrosis) and primary central nervous system lymphoma (PCNSL) may help to develop treatment plans. However, they share similar appearance in routine MR images. As a new diffusion model, neurite orientation dispersion and density imaging (NODDI) reflects the microstructure of tissue by measuring different components within it. Through quantitative analysis, we found that all parameters of NODDI performed excellent in distinguishing between atypical HGG and PCNSL.
Soma and Neurite Density Imaging (SANDI) characterizes microscopic differences between two glioma mouse model subtypes
Authors: Ianus Andrada , Palombo Marco , Simoes Rui , Henriques Rafael , Carvalho Tania , Shemesh Noam
Published: August 2024

Diffusion MRI (dMRI) provides an indirect characterisation of tissue features at the microscopic-scale. The Soma and Neurite Density Imaging (SANDI) methodology was initially proposed to quantity parameters of cell soma and neurite in brain white and gray matter. Here, we investigate the potential of employing SANDI as a general representation of isotropic, restricted, highly anisotropic and isotropic Gaussian components in two mouse models of glioma, derived from two cell lines with distinct microstructure (CT2A and GL261). The results reveal differences across the two tumour subtypes which are consistent with qualitative histological assessment.
Investigating the effect of thrombotic thrombocytopenic purpura on neurocognitive function using relaxation and myelin water fraction maps
Authors: Hannan Fahad , Jurkiewicz Michael , Thiessen Jonathan , Huang Susan
Published: August 2024

Despite being in remission, patients with immune-mediated thrombotic thrombocytopenic purpura (iTTP) experience a variety of cognitive health problems. Quantitative MRI was used to verify the health of white matter in 19 patients. Patients had increased T1 in the cingulate cortex and increased T2 in the frontal, parietal, and temporal lobes. These regions correlate with decreased cognitive scores and depression tests taken by patients alongside the MRI scan. Increased T1 and T2 could suggest a variety of tissue pathologies but require further investigation to determine exactly what condition is affecting white matter health.
MRI profiling of temporal lobe epilepsy with hippocampal sclerosis using multi-compartment diffusion models
Authors: Zhang Xiaonan , Zhao Guohua , Zhang Huiting , Gao Eryuan , Cheng Jingliang
Published: August 2024

The hippocampal microstructural alterations by using routine magnetic resonance imaging presents a challenge. This study aimed to evaluate the performance of the NODDI and MAP models in temporal lobe epilepsy (TLE) patients with hippocampal sclerosis (HS). Our results found that all NODDI and MAP parameters had significant differences between ipsilateral HS and contralateral HS/HC, and had MAP models better diagnostic performance than NODDI. In addition, combined MAP model had significant better diagnostic performance than all the single parameters. In conclusion, MAP is superior to NODDI in diagnosing TLE with HS.
Multi-exponential diffusivity spectroscopy with clinical DWI protocol has the potential to diagnose and characterize gliomas
Authors: Xu Junqi , Sheng Yaru , Li Hao , Wang Qianfeng , Yang Zidong , Ren Yan , Wang He
Published: August 2024

We present a multi-exponential diffusivity spectroscopy model to measure the diffusivity distribution of individual voxels in gliomas, which enables the comparison of the spectral fraction components between brain tumors and normal tissues. A neural network algorithm was used to speed up and improve the stability of the decomposition of multi-exponential decay data with a lower signal-to-noise ratio. The results show that diffusivity fractions of some spectral components were significantly different between IDH-mutant and -wild gliomas in grades 2 and 3.
Depression Related Structural Changes Based on 3D Brain MRI and Neural Fingerprint Assisted Segmentation
Authors: Wang Liya , Xu Peijia , Xue Ting , Deng Xiuliang , Wu Jiayi , Xue Xingkui
Published: August 2024

This study focused on the slight quantitative changes of brain structures based on the high-resolution brain MRI and automatic segmentation with neural fingerprint technology for whole-brain of depressive patients. We found the volume changes of specific regional sub-structures, which were related to emotion and spirit, such as the cingulate gyrus, cuneiform lobe, hippocampus, et al before clinical diagnosis. Depression revealed the gender difference. The male depressions were more sensitive to hippocampus, while female’s were more sensitive to entorhinal cortex. It might indicate ovarian hormone fluctuations modulate women’s susceptibility to stress, brain structure/function, and inflammatory activity and reactivity.
MicroCoP: digital Microstructure Correlation Phantoms for benchmarking of multicomponent MRI methods
Authors: Endt Sebastian , Pirkl Carolin , Palombo Marco , Menzel Marion
Published: August 2024

We present MicroCoP, a flexible tool for the generation of digital Microstructure Correlation Phantoms that can be used to benchmark multicomponent MRI reconstruction methods. The phantoms provide ground-truth distributions for the MR tissue parameters of your choice. These can be fed into forward simulations and thus provide a pair of ground-truth distributions and resulting signal evolutions to thoroughly evaluate multicomponent MRI reconstruction methods.
Virtual coil concept with multi-scale low-rank for real-time cardiac MR at 0.55T
Authors: Cruz Gastao , Hamilton Jesse , Cummings Evan , Liu Yuchi , Gulani Vikas , Seiberlich Nicole
Published: August 2024

Real-time MR applications are often highly undersampled due to the high temporal resolution required. Here, we propose a novel linear forward model combining virtual coils and multi-scale low-rank to enable highly accelerated real-time cardiac MR. The virtual coil concept leverages Hermitian symmetry, whereas multi-scale low-rank attempts to model real-time motion as a combination of subspaces across multiple image scales. Experiments in five healthy subjects demonstrate a considerable improvement in image quality over conventional iterative SENSE, enabling real-time cardiac imaging at 0.55T.