bluuebunny/crossref_metadata_2025 huggingface dataset:
Paisagem e desenvolvimento sustentável em territórios montanhosos
Authors: Amorim Mônica Alves , De Assis Renato Linhares
Published: November 2024

As estratégias tradicionais de desenvolvimento regional priorizam a expansão da produção com base em novos investimentos e ganhos de produtividade e competitividade a partir da atração de capitais exógenos. De outra forma, enfoque alternativo para valorizar produtos e serviços locais consiste em identificá-los com o território, incluindo características naturais, traços culturais e elementos construídos. Esse artigo tem por objetivo analisar, de forma propositiva, como valores intangíveis da paisagem, constituídos em produtos e serviços, podem potencializar processos de desenvolvimento territorial sustentável em ambientes de montanha. Destaca-se a importância da ênfase no aspecto endógeno na promoção do desenvolvimento sustentável em ambientes montanhosos. E, verifica-se que a paisagem diferenciada dos ambientes de montanha constitui aspectos que podem impulsionar a produção e geração de valor, trazendo a reboque empregos e ocupações produtivas, negócios, renda, vitalidade cultural e cuidados ambientais. Essa compreensão anuncia direções inovadoras para políticas públicas voltadas para o desenvolvimento sustentável de territórios montanhosos.
Sinais distintivos de mercado e desenvolvimento territorial: consensos e dissensões
Authors: Dos Anjos Flávio Sacco
Published: November 2024

O entusiasmo em torno à valorização do patrimônio agroalimentar, mormente da criação de sinais distintivos de mercado, reflete a ideia de que tais ativos possam converterem-se em vetores capazes de produzir a inovação, mas também em novas vias para o desenvolvimento dos territórios, fomentando a inovação e a coesão social. O objetivo central deste artigo é realizar uma reflexão crítica acerca de dois grandes instrumentos de distinção, quais sejam, as indicações geográficas e a patrimonialização de saberes-fazeres ligados à alimentação. A abordagem toma por base dados e informações coletados ao longo de cinco anos de cooperação entre grupos de pesquisa atuantes no Brasil e na Espanha com ênfase em entrevistas semiestruturadas realizadas nos dois âmbitos. Os resultados mostram as diferenças entre ambas as vias aludidas, as potencialidades destes instrumentos, e também as limitações e riscos que podem advir de uma sobrevalorização não controlada dos bens intangíveis dos territórios. Assegurar às populações implicadas os resultados que tanto anelam é uma missão complexa, sobretudo quando falam mais alto o imediatismo e os interesses dos agentes econômicos.
Evaluation of the Lipid Composition of Commercially Available Evening Primrose Products by Gas Chromatography and Mass Spectrometry
Authors: L. Figueiredo Alisson , D. S. Santos Patricia , S. Fernandes Cleverton , L. Fernandes Ingrid , C. Assakawa Amanda , A. Basso Ernani , O. Santos Oscar
Published: November 2024

Evening primrose oil supplements are rich in omega-6 fatty acids, with emphasis on linoleic and γ-linolenic acids, being taken in the treatment and prevention of diseases, but mainly for the relief of symptoms caused by premenstrual tension and menopause in women. This study aimed to evaluate the quality of the lipid profile of evening primrose oil supplements using gas chromatography techniques with a flame ionization detector and mass spectrometry with electrospray ionization. For this, eight commercially available national evening primrose oil brands were used. Of the eight samples analyzed, only two met all the standards established in legislation for fatty acids. The remaining capsules were subjected to triacylglycerol analysis and using a calibration curve the presence of soybean oil in the composition of the evening primrose oil capsules was verified. From the triacylglycerol with a mass/charge ratio of 901, it was possible to identify the addition of 31.16-85.88% of soybean oil in six of the eight capsules, leading the consumer to ingest products that did not comply with current legislation.
Analyzing the impact of climatic conditions on rainfed wheat yield in northwest Iran: a parametric and nonparametric approach
Authors: Khaledi-Alamdari Mohammad , Fakheri-Fard Ahmad , Majnooni-Heris Abolfazl , Eini Mohammad Reza
Published: November 2024

It is essential to comprehend the relationship between agricultural yields and climatic conditions, especially concerning food security and the possible threats to crop output. Wheat is a crucial agricultural crop that covers a significant amount of rainfed production regions in Iran. This study utilized parametric and nonparametric approaches to assess rainfed wheat yield. The study centered on the Tabriz area in northwest Iran, examining precipitation patterns concerning rainfed wheat cultivation. The study focused on analyzing seasonal and distinct rainfall patterns during the cultivation period, utilizing widely recognized drought metrics such as the standardized precipitation index and the standardized precipitation–evaporation index. The study findings indicate a notable upward trend in rainfed wheat output over the analyzed period. The Mann–Kendall test resulted in a p-value of 0.031, indicating statistical significance for the observed rising trend. We conducted trend removal and normalized rainfed wheat yield figures based on seasonal precipitation to study the data more thoroughly. The second phase of the growing season was particularly notable, spanning from the completion of germination to the beginning of blooming. Instead of analyzing precipitation for the full growing season, concentrating on fall precipitation or the time from germination to blooming might improve yield forecasts and determinations.
Dossier globalización/desglobalización y reconfiguraciones alternativas de mundos
Authors: Martínez Dueñas William Andrés
Published: November 2024

Este número especial de la revista invita a reflexionar en un contexto marcado por crisis como la pandemia de SARS-CoV-2, la disrupción de la cadena de suministros, los conflictos bélicos en Europa del Este y Medio Oriente, y las consecuencias socioecológicas del calentamiento global. Al mismo tiempo, hemos sido testigos de la consolidación de fenómenos que reconfiguran la interdependencia planetaria en los ámbitos socioculturales: el consumo masivo de contenidos audiovisuales a través de plataformas digitales, eventos internacionales como los Juegos Olímpicos, la revitalización del turismo global postpandemia y los nuevos flujos migratorios. Estos fenómenos, junto con las crisis mencionadas, nos invitan a cuestionar cómo lo “global” y lo “local” no son categorías opuestas, sino constructos dialógicos que permiten aproximarnos a las realidades contemporáneas.
Finding connections between the ITLOS Advisory Opinion on Flag State Responsibility for IUU Fishing and the advancement of Ocean Justice
Authors: Ventura Victor Alencar Mayer Feitosa , Zanella Tiago V.
Published: November 2024

The 2015 Advisory Opinion (AO) of the International Tribunal for the Law of the Sea (ITLOS) on illegal, unreported, and unregulated (IUU) fishing underscored the critical importance of due diligence obligations for flag states and represented a significant step in the upholding of the International Rule of Law and in the struggle towards ocean justice. The AO highlighted that flag states possess a duty to effectively exercise their jurisdiction and control over vessels flying their flag to prevent, deter, and eliminate IUU fishing activities. Furthermore, the AO emphasized the responsibility of flag states to cooperate with other states and international organizations to combat IUU fishing, thus fostering the shift from a historical and sectorial to a modern and integrated approach to fisheries’ management, especially among member states to the UN Convention on the Law of the Sea. In this paper, it is claimed that the AO revealed how valuable the work of international organizations such as the International Tribunal for the Law of the Sea (ITLOS) can be for the interpretation and consolidation of new juridical perspectives on ocean governance and may ultimately contribute to the ideal of blue justice.
A POSSIBILIDADE DE OFERECIMENTO DE MERCADORIA INDISPONÍVEL E NÃO CUMPRIMENTO DA OFERTA COMO INFRAÇÃO À ORDEM ECONÔMICA
Authors: Campos Pryscilla , Miranda Clementino Marco Bruno
Published: November 2024

O presente artigo, abordando a temática do oferecimento de mercadoria indisponível e o não cumprimento da oferta como infração à ordem econômica, nos termos da Lei nº 12.529/2011, é fundamental para compreender a inter-relação entre os princípios da ordem econômica e a defesa do consumidor, sobretudo dada a crescente difusão das práticas anticoncorrenciais que ferem os direitos consumeristas. Buscou analisar os conceitos de oferta e publicidade, em especial de publicidade chamariz, à luz dos princípios da ordem econômica, partindo do pressuposto de que proteção ao consumidor é manifestação basilar da ordem econômica equilibrada. Por conseguinte, o trabalho visa a responder a seguinte problemática: é possível considerar o oferecimento de mercadoria indisponível e o não cumprimento da oferta como infração à ordem econômica? Para tanto, utilizou-se o método lógico-dedutivo, por meio de levantamento bibliográfico, bem como de interpretação da legislação brasileira. Por fim, concluiu-se que, no panorama jurídico atual brasileiro, embora não exista menção específica à respectiva prática como infração à ordem econômica, é possível inferir sua natureza violadora da ordem econômica.
REVISITANDO O CONCEITO DE PROGRAMA ILUMINISTA
Authors: Paiva Luz Segundo Elpídio
Published: November 2024

O texto analisa o projeto racionalista do Código Civil e seu contraponto com o modelo do Código de Defesa do Consumidor. Sustenta que, apesar das marcadas diferenças, há permanências, especialmente, da perspectiva do programa iluminista. Discorre sobre a especificação do sujeito, problematiza lugares comuns acerca da constitucionalização do direito civil e situa aspectos da vulnerabilidade. Para isso recorre a noção de vida à crédito e a contextualiza no cenário brasileiro. Por fim, aponta para o caráter ilusório de narrativas modernas, o que inclui o Código.
PANORAMA DA INDENIZABILIDADE DO TEMPO DESPERDIÇADO PELO CONSUMIDOR NO ÂMBITO DAS RELAÇÕES JURÍDICAS DE CONSUMO
Authors: Carneiro Filho Humberto João , Da Silva Guimarães Elizabeth
Published: November 2024

O presente trabalho possui como objetivo geral analisar o atual cenário no Brasil da reparabilidade do dano sofrido pelo consumidor em razão de seu infrutífero dispêndio de tempo por conduta imputável ao fornecedor, mormente a aplicação da denominada “teoria do desvio produtivo”. Para tanto, foi utilizada a análise bibliográfica exploratória e descritiva centrada na obra de Marcos Dessaune e, ainda, análise documental, com especial atenção para acórdãos proferidos pelo Superior Tribunal de Justiça relativos ao tema. A ressarcibilidade do dano gerado pela conduta daquele que acarretou a outrem desnecessária perda do tempo útil, com especial atenção às relações de consumo, tem tido aceitação no direito nacional, com aprofundamento e mesmo crítica da temática pela doutrina especializada construída e desenvolvida nos últimos anos, bem como a contínua e recente aplicação da referida construção teórica no âmbito da jurisprudência pátria como dano moral. Reconhecidas as peculiaridades das relações de consumo, especialmente voltadas à tutela de um sujeito de direito débil e vulnerável, foram identificadas resistências à qualificação da teoria às relações de direito privado não consumeristas.
THE APPLICATION OF SWAN IDEA SOURCE ON BRIDAL FASHION
Authors: Ningrum Vinna Kumala , Russanti Irma
Published: November 2024

Swans are the most loyal animals that only mate once in a lifetime. The purpose of this research is to find out the process of making and the finished result of bridal fashion with a swan as the source of the idea. This research method uses a three-stage design process approach. This method consists of three stages of research: problem definition and research, creative exploration and implementation. The design direction was determined in the initial stage, and in the second stage, a moodboard was made. The implementation stage involves applying a swan feather and manipulating fabric decoration as the centre of attention on the bridal outfit. The process of manipulating fabric starts with preparing copper wire, segment fabric and brocade fabric, then cutting to form strands of swan feathers and sewn with balut stitch on all sides to unite the three materials. The results of this research show bridal fashion with feather-shaped manipulating fabric decoration, with two designs of men's and women's bridal fashion. The final result is the style of Muslim clothing, according to the provisions of Islamic law, intended to cover parts of the body that are inappropriate to be shown to the public. The primary material is tille sequins and satin maxmara lining with the appropriate size, but it does not show the shape of the woman's body so that it can be worn for Muslim women wearing hijab.
The Translator’s Dilemma: Howard Goldblatt’s Translation Strategies in “Life and Death Are Wearing Me Out”
Authors: Li Bofeng
Published: November 2024

Since the 21st century, under the backdrop of the “going global” strategy of Chinese culture, the international influence of Chinese literary works has been growing. Among them, Howard Goldblatt’s translation of “Life and Death Are Wearing Me Out” is an outstanding representative of the English translation of contemporary Chinese literature. The translator Howard Goldblatt’s masterful translation of the original work’s national culture, linguistic form, and special structure is key to the success of the translation in overseas markets. This paper studies specific translation examples from Goldblatt’s English version of “Life and Death Are Wearing Me Out” and analyzes the translator’s translation strategies from the perspective of Polysystem Theory. It also explores the reasons from several angles, including the translating subject, content, strategy, and sponsors. The study finds that the translator Howard Goldblatt has seized the opportunity of Chinese culture “going global” and skillfully combined domestication and foreignization in the translation process of “Life and Death Are Wearing Me Out” effectively conveying Chinese cultural elements to readers while considering their reading interests and cultural backgrounds, thus making the translation more appealing to target language readers and promoting its effective overseas dissemination.
Study on the Path of Synergistic Utilization of Foreign Investment in Chengdu-Chongqing Region in the Context of Domestic and International Two Circles of Economic Activity
Authors: Fuxia Gao , Yuan Cao
Published: November 2024

Under the new development pattern of domestic and international two circles of economic activity, it is of great significance for Chengdu-Chongqing region to utilize foreign investment in a coordinated manner. This study focuses on the opportunities and paths for the coordinated utilization of foreign investment in the Chengdu-Chongqing region in this context, and based on this, it provides the corresponding policy recommendations to help Chengdu-Chongqing region to better exert its own advantages, actively attract foreign investment, promote the high-quality development of the regional economy and synergistic advancement, and contribute to the steady growth of the national economy and the improvement of the international competitiveness. This will contribute to the stable growth of the national economy and the improvement of international competitiveness.
Optical Genome Mapping—A Cytogenomic Tool for Prenatal Diagnostics
Authors: Xiao Qing , Li Ziwei , Lu Jinzhi
Published: November 2024

Chromosome aberration is the main cause of human inherited diseases. The routine clinical tests still rely on the standardization of cellular genetics. In recent years, Optical Genome Mapping (OGM) has been developed as a high-view method to detect large-scale structural variation of human genome. It is capable of detecting structural variations which are difficult to be detected by other methods. OGM preliminarily applied in the comprehensive identification of genomic structural variations, the visual delineation of chromosomal rearrangement patterns, and the diagnosis of some dynamic mutation diseases. This review primarily focuses on the technical attributes of OGM and its application in the field of prenatal diagnosis.
Searching for Flow—An Interpretation of Wang Menmen’s Novel “Nomadism”
Authors: Duan Yuzhen
Published: November 2024

In “Nomadism”, the protagonist “Ren” integrates the modern society and “One-Hua Land” through the flow of perception and thought, exploring the fluidity of individual existence from multiple perspectives. The presentation of fluidity in this novel unfolds primarily through narrative flow, spatial fluidity, and bodily fluidity. By comparing the names and living spaces of the characters, the novel reflects on the existential dilemmas in fluid narrative and fluid spaces, and explores the meaning of existence amid the complex changes of subjective perception and external objects. The search for meaning involves not only perceiving it but also grasping its fluidity, which is a challenge not only for people in modern society but also for human beings throughout history.
FORMULATION AND EVALUATION OF LULICONAZOLE NANOEMULGEL USING BOX-BEHNKEN DESIGN APPROACH
Authors: S. PRATHVI , DS SANDEEP , JOSE JOBIN
Published: November 2024

Objective: The present study was aimed to develop and assess a Luliconazole-loaded nano emulgel for topical application.
Methods: Nanoemulsion of Luliconazole was prepared by ultrasonication method. A pseudo-ternary phase diagram was constructed to determine the ideal ratio of oil and the surfactant/co-surfactant mixture for nanoemulsion preparation. The Box Behnken statistical design was utilized to optimize the nanoemulsion. The optimized batch of nanoemulsion was incorporated into the 1% Carbopol gel as nanoemulgel. It was evaluated for various parameters like globule size, zeta potential, pH, spreadability, viscosity, drug content, drug release, ex vivo permeation study, in vivo animal skin irritation study, and histopathology studies.
Results: The optimized formulation showed a globule size of 130.5 nm and entrapment efficiency of 80% and the values were found to be within±5% of predicted values, indicating the suggested statistical model was significant at 95% of confidence interval. The zeta potential of the formulation was found to be-22.1 mV, indicating enhanced stability of the formulation. Transmission Electron Microscopy (TEM) images revealed that the formulation had a smooth surface texture with a mean globule size meeting the nanoscale size range. The drug release study demonstrated a sustained release pattern for the formulation, with a maximum release of 74.93±0.8% over 8 h. The formulated gel exhibited appreciable ex vivo permeability. An in vivo skin irritation test on Wister rats showed no signs of skin irritation from the formulation. The histopathological examination further confirmed that the formulation was dermatologically safe, exhibiting no toxicity or irritation.
Conclusion: The results of the present study concluded that Luliconazole-loaded nanoemulgel could be a potential topical drug delivery approach for the management of fungal infections.
DEVELOPMENT OF 1H-INDAZOLE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS USING COMPUTATIONAL METHODS
Authors: NANAWARE RAJESH B. , CHABUKSWAR ANURUDDHA R. , ADSULE PRAJAKTA V. , JAGDALE SWATI C. , RAUT KUNAL G.
Published: November 2024

Objective: Due to the rising prevalence of disorders linked to inflammation, there is a greater emphasis on the discovery and development of anti-inflammatory drugs, with a focus on producing new structural compounds.
Methods: In this research, molecular docking and Molecular Dynamics (MD) simulation study were carried out to evaluate the 1H-indazole analogs as potent anti-inflammatory agents.
Results: The compounds containing difluorophenyl, para-toulene and 4-methoxyphenyl group shows significant binding results (9.11, 8.80 and 8.46 kcal/mol respectively) when docked with Cyclooxygenase-2 (COX-2) enzyme 3NT1. The results of the MD simulation indicated that test compound BDF was relatively stable in the COX-2 enzymes active sites. The compound BDF-3NT1 demonstrated substantial affinities for binding with all of its aimed targets following a dynamic Molecular Mechanics with Generalized Born Surface Area (MM-GBSA) analysis.
Conclusion: In accordance to this study, newly developed 1H-indazole compounds have the potential for treating inflammation.
RENOPROTECTIVE POTENTIAL OF FLAVONOIDS-RICH AGAINST DOXORUBICIN-INDUCED IN ANIMAL MODELS: A REVIEW
Authors: WATI DINI PRASTYO , ILYAS SYAFRUDDIN
Published: November 2024

Cancer significantly impacts human health, affecting one in five people during their lifetime. While chemotherapeutic agents like doxorubicin are crucial in treating various cancers, they are also associated with severe side effects, including nephrotoxicity. This review examines the renoprotective potential of flavonoids against doxorubicin-induced renal damage in animal models. Doxorubicin works by intercalating Deoxyribo Nucleic Acid (DNA) and making Reactive Oxygen Species (ROS), which cause apoptosis and the death of cells. A thorough literature analysis was done to collect relevant papers on the impact of flavonoid-rich therapies as renoprotective agents against doxorubicin-induced nephrotoxicity. Databases such as Google Scholar, Scopus, PubMed, Springer, Wiley Online Library, and ScienceDirect were searched using keywords including "flavonoids, doxorubicin, renoprotective, nephrotoxicity, and animal model," focusing on publications from 2014 to 2024. Flavonoids are diverse polyphenolic compounds in many plants with significant pharmacological properties such as antioxidant, anti-inflammatory, and anticancer effects. This review highlights the renoprotective potential of flavonoids like quercetin, rutin, kaempferol, morin, luteolin, apigenin, hesperidin, naringenin, diosmin, and anthocyanins. These compounds reduce renal toxicity through mechanisms that decrease ROS, lipid peroxidation, mitochondrial permeability, and apoptosis.
EVALUATION OF AN ANTI-DANDRUFF SHAMPOO INCORPORATING ETHANOL EXTRACT FROM CORN SILK (ZEA MAYS L.) AGAINST CANDIDA ALBICANS FUNGUS: FORMULATION AND ACTIVITY ASSESSMENT
Authors: LENY  , SARI MELIA , GINTING MANDIKE , MELISA  , ISKANDAR BENNI
Published: November 2024

Objective: The aim of this study was to investigate the effectiveness of corn silk (Zea mays L.) extract as an antifungal ingredient in shampoo formulation for treating dandruff caused by Candida albicans.
Methods: Plant identification, sampling, preparation of simplisia, phytochemical screening, simplisia characterization, ethanol extraction of corn silk, and the formulation of shampoos with extract concentrations of 5%, 10%, and 15%, alongside blank and positive controls. The formulations underwent physical evaluation, irritation testing, and antifungal activity testing using the disc diffusion method.
Results: The corn silk shampoo formulations were stable during storage, non-irritating, was in thick liquid form with yellowish to brown colour, corn scent, had pH between 5.0-5.8, foaming capacity at 10.3-13.0 cm, with the viscocity ranging 1967-2224 cPs, means it met the required standards for shampoo formulation and characterization. Antifungal testing revealed inhibition zone diameters of 0 mm for the blank (F0), 7.87 mm for F1 (5%), 9.46 mm for F2 (10%), 15.89 mm for F3 (15%), and 18.71 mm for the positive control (C+), with a one-way ANOVA test indicating a significant difference compared to the negative control.
Conclusion: Corn silk extract could be effectively formulated into an antifungal shampoo, with the 15% concentration being the most effective against Candida albicans, highlighting its potential as a natural ingredient for anti-dandruff shampoos.
FORMULATION AND IN VITRO TESTS OF KETOPROFEN NANOSUSPENSION USING THE MILLING METHOD WITH POLYMER VARIATIONS
Authors: HANUM TENGKU ISMANELLY , PRASETYO BAYU EKO , FADILLA WAN
Published: November 2024

Objective: The aim of this research was to formulate ketoprofen nanosuspension with a variety of polymers and to compare the dissolution rate of the nanosuspensions with ketoprofen suspension.
Methods: Ketoprofen nanosuspension was formulated by milling method using a different polymer such as Polyvinyl Pyrrolidone (PVP) K-30 (F1), Polyvinyl Alcohol (PVA) (F2) and Hydroxy Propyl Methyl Cellulose (HPMC) (F3). Nanosuspensions were prepared and characterized, including organoleptic, pH, particle size, zeta potential, Polydispersity Index (PI), specific gravity, crystalline state determination, physical stability at room temperature for 3 mo, and in vitro dissolution test compared with ketoprofen suspension.
Results: The ketoprofen nanosuspensions with PVP K-30 and PVA showed stable preparations, while those with HPMC showed less stability, as indicated by sedimentation during storage. The particle size values of PVP K-30 and PVA were 10.004±0.03 nm; and 9.560±0.01 nm; zeta potential and polydispersity index values met the test requirements. The dissolution rate of the ketoprofen nanosuspensions was higher with a cumulative of F1, F2, and F3 were 83.35%; 85.00%, and 81.09% after 60 min, while the ketoprofen suspension was only 7.62%.
Conclusion: The milling method of ketoprofen nanosuspensions with PVP and PVA has more stable physical characteristics than nanosuspension with HPMC. The ketoprofen nanosuspensions have a higher dissolution rate than the ketoprofen suspension.
THE CHOICE OF COMPONENTS AND THE IMPACT OF SURFACTANTS AND CO-SURFACTANTS ON EPLERENONE NANOEMULSION SYNTHESIS FOR GEL-BASED TRANSDERMAL APPLICATION
Authors: GAIKWAD MAHESH T , MARATHE RAJENDRA P , PATHAN INAYAT B
Published: November 2024

Objective: This research aims to establish an efficient methodology for selecting nanoemulsion components to synthesize eplerenone nanoemulsion for gel-based transdermal applications.
Methods: The chemical compatibility study of eplerenone was investigated by FTIR, DSC, and solubility in oils, surfactants, and co-surfactants as the criteria for choice. We used visual appraisal and grading to assess the effectiveness of emulsification. Various excipients were tested depending on solubility. The final appearance, dispersibility, and ease of emulsification were used to visually assess the degree of self-emulsification of oil and emulsifier in a 1:3 mass ratio. Co-surfactants were assessed by mixing particular emulsifiers in a 2:1 (w/w) ratio with co-surfactants, and the oily component was added at a 1:3 (w/w) ratio to evaluate Smix's emulsification potential. A central composite design synthesized, evaluated, and optimized eplerenone nanoemulsions. Optimized nanoemulsions were characterized after a thermodynamic stability study for droplet size, ζ potential, viscosity, refractive index, pH measurements, and TEM. All the selected formulations were found to be stable, and the droplet size was found to be<110 nm.
Results: Eplerenone was chemically compatible, and its maximum solubility was 171.3±0.92 and 169.3±2.22 in Kollicream®OA and Paceol, respectively. The evidence impressively found that Tween 20 and Kolliphor®EL were discovered as active emulsifiers, and Transcutol®P was revealed to be a co-surfactant. Outcomes showed that the emulsification efficacy of Kolliphor®EL (3% w/w) was able to emulsify Kollicream®OA (1% w/w), and Paceol failed. As well, Smix [Kolliphor®EL (2% w/w) and Transcutol®P (1% w/w)] were able to emulsify Kollicream®OA (1% w/w).
Conclusion: The main conclusion from this work is the application of a visual appraisal and grading system to assess the final appearance, dispersibility, and ease of emulsification to eradicate the toxicity and irritation that nanoemulsions can cause. Optimised nanoemulsions can further formulate eplerenone's nanoemulsion gel for transdermal application.
PHARMACEUTICAL NANOCRYSTALS: AN EXTENSIVE OVERVIEW
Authors: SIVANATHAN GURUBARAN , RAJAGOPAL SANJAI , MAHADEVASWAMY GIRIDHARA , ANGAMUTHU GOWTHAM , DHANDAPANI NAGASAMY VENKATESH
Published: November 2024

In pharmaceutical development, pharmaceutical nanocrystals sized between 10 and 1000 nanometers have been found to hold promise in improving drug solubility. Since they comprise only the active pharmaceutical ingredient, nanocrystals have dramatically increased surface area-to-volume ratios, ensuring improved in vitro dissolution and solubility profiles.
In view of their strengths and limitations, different production strategies have been reviewed: methods of size reduction such as wet milling and high-pressure homogenization; the bottom-up approaches of controlled precipitation and supercritical fluid technology; and efficient ways to stabilize nanocrystal formulations aided by excipients like surfactants and polymers.
Techniques used in this characterization of nanocrystals include size analysis, surface-charge measurement, and assessment of crystalline structure. The routes of administration, such as oral, injectable, inhaled, and topical application, are reviewed alongside commercially successful products and clinical trials.
This work reviews dynamic regulatory scenarios and current challenges of large-scale production, long-term stability, and nanotoxicity evaluation. In addition, it addresses the emerging trends in nanocrystal technology in the field of personalized medicine, targeted drug delivery, and theranostic approaches associated with how nanocrystals can help optimize the outcome of a patient in drug delivery systems.
DESIGN, SYNTHESIS, IN SILICO STUDIES, AND PHARMACOLOGICAL EVALUATION OF 5-ARYL-4-(CHLOROACETYLAMINO)-3-MERCAPTO-1,2,4-TRIAZOLE DERIVATIVES AS ANTICONVULSANT AGENTS
Authors: JAIN RUPSHEE , P. PRABITHA , KUMAR B. R. PRASHANTHA , JAIN VIKAS , G. MAHENDRA , SHIVAJI KAMBLE SWAPNIL , KASHAW SUSHIL K. , KOHLI D. V.
Published: November 2024

Objective: In this study, we reported the synthesis of a novel series of 5-aryl-4(chloroacetylamino)-3-mercapto-1, 2,4-triazoles.
Methods: These compounds were synthesized to screen for anticonvulsant effects in a Maximal Electroshock Seizure (MES) model and a Subcutaneous Pentylenetetrazole (sc‐PTZ) seizure model in rats. Furthermore, molecular docking studies with gamma-aminobutyric acid and in silico ADME prediction were carried out to determine interactions of these compounds with Benzodiazepine (BZD) receptors and their similarity with standard drugs. The rotarod test was used to evaluate neurotoxicity.
Results: 08 out of 40 compounds exhibited neurotoxicity at the maximum tested dose. Most of the compounds showed anti‐MES effects without any signs of neurological deficit. All the tested compounds significantly reduced seizures induced by PTZ compared to the control group. Carbamazepine and phenytoin were used as positive controls for anticonvulsant effects. Compounds 3d, 3h (a diphenylamine derivative of 5-aryl-4(chloroacetylamino)-3-mercapto-1,2,4-triazole), and 4a (a piperidinyl derivative of 5-aryl-4(chloroacetylamino)-3-mercapto-1,2,4-triazole) exhibited greater safety than phenytoin and carbamazepine in terms of neurotoxicity. The docking scores for the identified compounds 3d, 3h and 4a was 6.5133; 6.6558 and 5.6524, respectively. Nearly all the compounds (90%) demonstrated decreased locomotor activity.
Conclusion: It is gratifying that the compounds with higher hydrophobicity showed better performance in the seizure models. Many triazole derivatives holding a suitable aryl or alkyl group gave a better anticonvulsant activity in their analogs.
Pengaruh Environmental Concern terhadap Purchase Intention pada Produk Skincare Organik
Authors: Cahyaningrum Avisa Regina , Tresnawaty Yulistin
Published: November 2024

Makin naiknya perhatian terhadap masalah lingkungan mendorong konsumen untuk lebih selektif dalam memilih produk yang berkelanjutan seperti produk skincare  organik berbahan alami dalam rutinitas sehari-hari. Penelitian ini bertujuan untuk mengetahui seberapa besar pengaruh kepedulian lingkungan individu terhadap niat membeli produk skincare organik. Penelitian ini menggunakan penelitian pendekatan kuantitatif yang melibatkan 275 responden pengguna produk skincare ramah lingkungan/organik berbahan alami berusia 17-40 tahun. Pengambilan sampel menggunakan teknik incidental sampling. Dalam penelitian ini menggunakan metode regresi linear dengan bantuan IBM SPSS versi 25. Pengumpulan data yang digunakan untuk mengukur variabel environmental concern adalah environmental concern scale memiliki nilai Cronbach’s Alpha sebesar 0,793. Pengumpulan data yang digunakan untuk mengukur variabel purchase intention adalah purchase intention for green products scale memiliki nilai Cronbach’s Alpha sebesar 0,893. Hasil analisis menunjukkan bahwa environmental concern berpengaruh signifikan positif terhadap purchase intention sebesar 26,6% dengan nilai koefisien yang diperoleh adalah F= 98,515 p= 0,000 dan B= 0,508. Dari hasil penelitian ini, dapat disimpulkan bahwa semakin tinggi environmental concern pada individu maka semakin tinggi purchase intention individu terhadap pengguna skincare organik.
 
The increasing attention to environmental issues encourages consumers to be more selective in choosing sustainable products such as organic skincare products made from natural ingredients in their daily routine. This study aims to determine how much influence individual environmental concerns have on the intention to buy organic skincare products. This study uses a quantitative approach research involving 275 respondents who are users of environmentally friendly/organic skincare products made from natural ingredients aged 17-40 years. Sampling using incidental sampling technique. In this study using the linear regression method with the help of IBM SPSS version 25. Data collection used to measure environmental concern variables is the environmental concern scale which has a Cronbach’s Alpha value of 0.793. Data collection used to measure purchase intention variables is purchase intention for green products scale has a Cronbach’s Alpha value of 0.893. The results of the analysis show that environmental concern has a significant positive effect on purchase intention by 26.6% with the coefficient value obtained is F= 98.515 p= 0.000 and B= 0.508. From the results of this study, it can be concluded that the higher the environmental concern of individuals, the higher the individual purchase intention of organic skincare users.
Marhata sebagai Rekonsiliasi Konflik Tanah Warisan Antar Marga di Desa Hatinggian Kabupaten Toba
Authors: Sinaga Winda Safrina , Tampake Tony , Supratikno Agus
Published: November 2024

Sistem pembagian tanah warisan bagi Masyarakat Batak Toba sering sekali menjadi konflik, seperti konflik antar marga Sirait dan Sinaga yang ada di Desa Hatinggian. Konflik muncul karena para pemilik tanah telah meninggal, anak cucu pergi merantau, dan tanah tidak memiliki sertifikat karena diwariskan secara turun-temurun. Studi ini bertujuan untuk menggambarkan tradisi marhata sebagai rekonsiliasi konflik dalam penyelesaian konflik tanah warisan antar marga di Desa Hatinggian Kabupaten Toba. Penelitian ini menggunakan teori konflik oleh Lewis A. Coser, teori tindakan sosial oleh Max Weber yang berfokus pada teori tindakan rasionalitas instrumental dan teori tindakan tradisional untuk melihat langkah-langkah penyelesaian konflik tanah warisan antar marga. Penelitian ini menggunakan metode kualitatif dengan pendekatan studi kasus. Pengumpulan data dilakukan dengan wawancara dan observasi dan studi dokumen. Informan dalam penelitian ini adalah marga yang berkonflik dan para tokoh adat. Analisis data dengan melakukan reduksi data, penyajian data dan penarikan kesimpulan/verifikasi. Hasil studi ini menunjukkan bahwa tradisi marhata menjadi dialog terbuka dan partisipatif dengan menjunjung tinggi nilai-nilai kejujuran, keterbukaan, dan  rasa hormat. Setiap pihak menyampaikan pandangan dan keluhannya, sehingga solusi yang adil dan diterima oleh semua pihak tercapai dan tercipta perdamaian sehingga tradisi ini perlu dipertahankan.
 
The inheritance land distribution system for the Toba Batak community often becomes a conflict, such as the conflict between the Sirait and Sinaga clans in Hatinggian Village. The conflict arises because the landowners have died, their children and grandchildren have gone abroad, and the land does not have a certificate because it is inherited from generation to generation. This study aims to describe the marhata tradition as a conflict reconciliation in resolving inheritance land conflicts between clans in Hatinggian Village, Toba Regency. This study uses conflict theory by Lewis A. Coser, social action theory by Max Weber which focuses on the theory of instrumental rationality action and traditional action theory to see the steps to resolve inheritance land conflicts between clans. This study uses a qualitative method with a case study approach. Data collection was carried out through interviews and observations and document studies. The informants in this study were the conflicting clans and traditional leaders. Data analysis by conducting data reduction, data presentation and drawing conclusions/verification. The results of this study indicate that the marhata tradition is an open and participatory dialogue by upholding the values ​​of honesty, openness, and respect. Each party conveys their views and complaints, so that a fair and acceptable solution is achieved by all parties and peace is created so that this tradition needs to be maintained.
Narrative misinformation from a credible source can be discredited with counternarrative
Authors: Johnson Nathanael , Sparks Glenn
Published: November 2024

Former government intelligence officer David Grusch became a hot new topic in the UFO world when he declared that the government was hiding an alien ship crash retrieval program. Can this media coverage be influential in increasing belief in UFOs? And can a credible critic of Grusch's claims successfully negate the impact of the media coverage on the acceptance of misinformation? A three-condition experiment (N\,=\,287) showed that a counternarrative can successfully negate the influence of his claims on conspiratorial beliefs. We suggest that these results have practical implications for journalists in their coverage of controversial claims.
Scattering wave packets of hadrons in gauge theories: Preparation on a quantum computer
Authors: Davoudi Zohreh , Hsieh Chung-Chun , Kadam Saurabh V.
Published: November 2024

Quantum simulation holds promise of enabling a complete description of high-energy scattering processes rooted in gauge theories of the Standard Model. A first step in such simulations is preparation of interacting hadronic wave packets. To create the wave packets, one typically resorts to adiabatic evolution to bridge between wave packets in the free theory and those in the interacting theory, rendering the simulation resource intensive. In this work, we construct a wave-packet creation operator directly in the interacting theory to circumvent adiabatic evolution, taking advantage of resource-efficient schemes for ground-state preparation, such as variational quantum eigensolvers. By means of an ansatz for bound mesonic excitations in confining gauge theories, which is subsequently optimized using classical or quantum methods, we show that interacting mesonic wave packets can be created efficiently and accurately using digital quantum algorithms that we develop. Specifically, we obtain high-fidelity mesonic wave packets in the Z2 and U(1) lattice gauge theories coupled to fermionic matter in 1+1 dimensions. Our method is applicable to both perturbative and non-perturbative regimes of couplings. The wave-packet creation circuit for the case of the Z2 lattice gauge theory is built and implemented on the Quantinuum H1-1 trapped-ion quantum computer using 13 qubits and up to 308 entangling gates. The fidelities agree well with classical benchmark calculations after employing a simple symmetry-based noise-mitigation technique. This work serves as a step toward quantum computing scattering processes in quantum chromodynamics.
CATEGORIZACIÓN DEL CONSTRUCTO “VALOR COMPARTIDO” A TRAVÉS DEL MÉTODO HERMENÉUTICO
Authors: Lugo Báez Cecilia Margarita , Canobbio Rojas Claudia
Published: November 2024

La presente investigación tiene como objetivo realizar un análisis hermenéutico mediante la revisión de la literatura e investigación documental, con respecto al constructo teórico Creación de Valor Compartido. El método se desarrolló en base al paradigma humanista, al poner énfasis en la interpretación del fenómeno, a través de un ejercicio de interpretación intencional y construcción contextual. Los resultados destacan la relevancia de las categorías orientativas: partes interesadas, clúster, capacidades directivas e innovación social, por su grado de enraizamiento en la teoría analizada. Respecto a las categorías emergentes, los resultados más destacables correspondieron a las categorías: RSE, Sostenibilidad ambiental, económica y social, así como también la ventaja competitiva. El análisis realizado permitió identificar sus dimensiones de estudio: innovación de productos y mercados, asociaciones colaborativas por medio de clústeres y cadena de valor, que por si mismas, implicaron incialmente un total de 19 categorías orientadoras; pero una vez realizado el ejercicio analítico, surgieron otras 9 categorías emergentes; sirviendo de ruta para generar nuevas líneas de investigación relacionadas con dicha categoría de análisis.
Elevating Facial Expression Detection: Empowered by VGG-19 and Weight-Normalized Gradient Boost Algorithm
Authors: M Rajeshwari , K Krishna Prasad
Published: November 2024

Facial expression recognition termed as FER, is one of the vital tasks which is able in mimicking the human ability and wellness. Face expression and other gestures delivered via face are some of the important aspects of conveying non-verbal communications which plays a vital role in interpersonal relations. This domain has a higher scope of research due to enhancing computer vision and human-computer interaction. With respect and consideration to these domain interest, DL has gained a reasonable approach in performing FER. Some of the state-of-art approaches encompassing the ML approaches have faced several cases of laybacks such as overfitting, computational complexity, less adaptable to higher and big datasets. Thus, considering these laybacks and in achieving accurate FER in aspects of bringing proximal levels of FER, the current approach deployed DL methods for both feature extraction from the input image and in classifying them. Deep multi-level feature extraction is performed using the VGG-19 model and Weight Normalized gradient boosting algorithm is adapted for classifying these expressions using the FER13 dataset. This dataset constitutes the input images, which are in ranges of 28,709 sample image data and about 3,589 image data for test. These input images are initially pre-processed for obtaining better accuracy rates when performing feature extraction and classifications. The complete model in effective FER is evaluated using the performance metrics comprising Accuracy (98%), Recall (99%), F1-score (98%) and the precision rates (97%). This analysis of the performance will aid in affirming the overall efficacy of the proposed system.
The Motif of Traveling around the Estate House in B.K. Zaitsev’s Tetralogy “Gleb’s Travels”
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Andreeva Valeria G.
Published: November 2024

The article examines the motif of traveling around the house, traveling around the room in B.K. Zaitsev’s tetralogy “Gleb’s Travels” (1934–1952). The deep connection of this motif with the estate theme is noted. The motif of the path contains many intersecting realizations and is impossible without the idea of different places — the place that is left (often an estate), and those visited on the journey. The author of the article analyzes one of the key episodes in the entire tetralogy of Gleb and Sonya’s journey around the room, shows its meaning and functions in the tetralogy. The connection of this episode with the literary tradition and its creative development by the writer are noted. It is proved that Gleb undergoes a kind of initiation rite on this conditional journey. The game of Gleb, who is transitioning to adulthood, correlates with one of the games of his childhood and acquires many hidden meanings. The significance of this symbolic action in the fate of Gleb is examined, it is stated that it was able to take place thanks to life in the estate, the presence of the estate history of the family, previously undertaken trips to the house and rooms, as well as Gleb’s rich imagination. Going on a journey around the room, Gleb understands that his human and literary fate is not in the hands of the populist editor who rejected his article, but in the hands of God. The article draws an interesting parallel between Gleb’s symbolic journey and other journeys: from the journey of the hero of the book “A Journey Through My Room” by Xavier de Maistre to the “as if a journey” of Mikhail Alpatov, the hero of the novel “Kashcheev’s Chain” by M.M. Prishvin, the similarity of the episodes in the indicated works.
The Estate in Fantasy Literature: Bag End by J.R.R. Tolkien as the Quintessence of Home Comfort
Authors: Zekunova Anna L.
Published: November 2024

The article considers how the traditions of Victorian and Edwardian England, focus on home comfort, a sense of security and safety are reflected in the story of J.R.R. Tolkien’s “The Hobbit, or There and Back Again” (1937), in the description of the hero’s small warm hole. The “estate” of a hobbit (halfling) is a hole dug under a hill (and thus mostly hidden underground), but furnished with maximum comfort. Such an “estate” is a real fortress, a nest that you never want to leave, a model of a closed world. Tolkien creates an ideal, eternally calm, unshakable, unchanging world, a space for escapism, where the everyday life of the heroes is depicted in the traditions of ancient bucolics — and thereby sending readers to “good old England”, where you can hide from everyday storms and conflicts, where a small English “estate” becomes a fortress, and its walls give a protection from outer evils.
The Destiny of Chemin de Paradis: Museumification of Charles Maurras’s Estate
Authors:   Takushioku University, Molodyakov Vasily E.
Published: November 2024

In the life and work of French writer and essayist Charles Maurras (1868– 1952), born in a Provençal town Martigues (Dept. Bouches-du-Rhône), ancestral estate Chemin de Paradis (Way to Paradise) occupied a very special place. Thinking the estate as his familial as well as the quintessence of his “small motherland” (Martigues) Maurras filled the garden with historical relics and designed the memorial architectural composition La Mur des Fastes (Wall of Glory) as its semantic center. The estate became one of Morras’s major works, which is why he, being imprisoned after the Second World War, took care of its preservation for next generations as public treasure, in what the society Les Amis du Chemin de Paradis (Friends of Chemin de Paradis) played an important role. The article explores for the first time the museumification of the estate which Maurras bequeathed to the city of Martigues. Converted first into a private museum, the estate was lately handed over to the city after long and difficult negotiations. Now this is a municipal house-museum temporarily closed for public.