bluuebunny/crossref_metadata_2025 huggingface dataset:
Culture, Language and Thought: Field Studies on Colour Concepts
Authors: Groh Arnold
Published: March 2016

In a series of studies the assumption of a lack of colour concepts in indigenous societies, as proposed by Berlin and Kay and others, was examined. The research took place in the form of minimally invasive field encounters with indigenous subjects in South East Asia and in India, as well as in West, Central, and South Africa. Subjects were screened for colour blindness using the Ishihara and Pflüger-Trident tests. Standardised colour tablets had to be designated in the indigenous languages; these terms were later translated by native speakers of the indigenous languages into a European language. The indigenous subjects were able to name the colours presented. Indigenous vs. globalised cultural factors were reflected in the use of reference objects for naming colours. Both metonymical and non-metonymical indigenous colour names did not follow a stage pattern as Berlin and Kay and others have proposed. The high precision of indigenous colour names corresponds both to the precision of experts’ colour names in the industrial culture, and to the highly precise grammar that characterises indigenous languages. It is concluded that cognitive categorisation of visual perception takes place regardless of the cultural context, and that former misunderstandings resulted from inappropriate methodological designs.
Methodological Consilience of Evolutionary Ethics and Cognitive Science of Religion
Authors: Franek Juraj
Published: March 2016

For the larger part of modern western intellectual history, it has been assumed that the study of morality and religion requires special methodology, insulated from, and in some important aspects incongruent with, the scientific method commonly used in the realm of natural sciences. Furthermore, even if it would be granted that moral and religious behavior is amendable to scientific analysis, the prospects of using evolutionary theory in particular to do the heavy lifting in explanation of these phenomena have been bleak, since many scholars doubted that a biological theory could possibly offer any valuable contribution. Recent advances in the fields of Evolutionary Ethics and Cognitive Science of Religion disprove both claims, emphasizing empirically founded explanations, demonstrating extraordinarily high degree of methodological consilience, and revealing utmost importance of the application of evolutionary theory in fields of study once deemed to be exclusive domains of social sciences and philosophy.
Sic vivere est devote vivere
Authors: Gaens Tom
Published: March 2016

This essay outlines the theology of “modern-day” devotion, as it can be found in the works of the Carthusian monk Henry of Coesfeld (d. 1410). This theology consists of a classical Thomist framework, infused with ideas from Brabantine and Rhineland mysticism (e.g., Ruusbroec, Suso) and Carthusian spirituality, in which contempt for the world, purity of the heart, progression in the virtues, repentance and inner renewal, Eucharistic piety, meditation on Christ’s humanity and passion, “Christiformity,” and the imitation of Christ, play a central role. While pointing at the “present-day” moral decline in the religious orders and the church, Henry’s idea of devotion relates to personal reform, a process of becoming congruent with the “ancient” examples of Christ and the saints. His theology is not anti-mystical and anti-intellectual in nature, but at the same time it warns against the pitfalls of curiosity (curiositas) and the excesses of mysticism.
Ad modum Cartusiensium
Authors: van Aelst José
Published: March 2016

After the enclosure of the Saint-Agnes convent at Maaseik in 1430, the regular canonesses had to learn how to live within the claustrum. They received support from at least two Carthusian monks: James of Gruitrode, prior of the charterhouse in Liège, and Denys the Carthusian from the charterhouse of Roermond. Both Carthusians maintained a regular contact and exchanged literature. James seemingly had a close relation with the nuns: he helped them enlarge their corpus of relevant religious literature, and there is evidence that he was involved in practical matters of the convent. Denys corresponded with the mater of the canonesses, at whose request he sent an elaborate instruction on life within the enclosed convent, De vita inclusarum. In this triangle of religious relations, the Carthusians, experts in enclosed life, took their pastoral responsibility to support the reform of the canonesses and used the means available to them: the written word.
A new species of Lamprodila (Ovalisia Kerremans, 1900) (Coleoptera: Buprestidae) from Sulawesi, Indonesia
Authors: LEVEY BRIAN
Published: March 2016

There have been a number of fairly recent papers dealing with Ovalisia Kerremans, 1900 under different generic or subgeneric names: Bílý (1993, as Pagdeniella Théry, 1935; 1997, as Ovalisia), Bílý et al. (2009, as Lamprodila (Ovalisia), Hołyński (2000, 2011a, 2011b, as Ovalisia). Hołyński (2011a, 2011b) has a number of misgivings over using the name Lamprodila Motschulsky 1860 for the genus containing the subgenus Ovalisia Kerremans, however as there does not appear to be any objective way to confirm or refute Hołyński’s views concerning Motschulsky’s intentions when he coined the name Lamprodila, I choose to follow the recent catalogues of Kubáň 2006 and Bellamy 2008 who treat Ovalisia Kerremans, 1900 as a subgenus of Lamprodila.
A new species of the genus Pachytriton (Caudata: Salamandridae) from Hunan and Guangxi, southeastern China
Authors: YUAN ZHI-YONG , ZHANG BAO-LIN , CHE JING
Published: March 2016

Despite recent descriptions of multiple new species of the genus Pachytriton (Salamandridae), species richness in this China-endemic newts genus likely remains underestimated. In this study, we describe a new species of Pachytriton from northeastern Guangxi and southern Hunan, southeastern China. Both molecular analyses and morphological characters reveal that the new species can be distinguished from its congeners. The mitochondrial gene tree identified the new lineage highly divergent (uncorrected p-distance > 5.8 % by mitochondrial gene) from currently recognized species and placed it as the sister species of P. xanthospilos and P. changi. Furthermore, a nuclear gene haplotype network revealed a unique haplotype in the new populations. Statistical species delimitation using Bayes factor strongly supported the evolutionary independence of the new species from the closely-related P. xanthospilos. Morphologically, the new species is characterized by a uniformly dark brown dorsum without bright orange dots or black spots; irregular orange blotches on the venter; tips of fingers and toes orange on the dorsal side; moderately developed webs on the side of digits; absence of costal grooves between the axilla and groin; and widely open vomerine tooth series.
Key to species of the genus Bambusananus Li & Xing (Hemiptera: Cicadellidae: Deltocephalinae), and with description of a new species from China
Authors: XING JI-CHUN , LI ZI-ZHONG
Published: March 2016

A new species, Bambusananus bispinosus sp. nov., is described and illustrated from Yunnan Province, China. A key based on the aedeagus is given to distinguish all species of the genus. The type specimens of the new species are deposited in the Institute of Entomology, Guizhou University, Guiyang, China (GUGC).
Body dissatisfaction and psychological distress in adolescents: Is self-esteem a mediator?
Authors: Duchesne Annie-Pier , Dion Jacinthe , Lalande Daniel , Bégin Catherine , Émond Claudie , Lalande Gilles , McDuff Pierre
Published: March 2016

This brief report tests the mediating effect of self-esteem in the relationship between body dissatisfaction and symptoms of depression and anxiety. A sample of 409 adolescents (females = 58.4%) aged between 14 and 18 years completed the Rosenberg Self-Esteem Scale, the Contour Drawing Rating Scale, the Multidimensional Anxiety Scale for Children, and the Center for Epidemiologic Studies Depression Scale. Overall, results for the indirect effects analysis were significant for both anxiety and depression, which confirmed the mediating role of self-esteem. Thus, a negative perception of one’s body image has the effect of lowering self-esteem, which in turn increases psychological distress.
Tumor-reactive immune cells protect against metastatic tumor and induce immunoediting of indolent but not quiescent tumor cells
Authors: Payne Kyle K , Keim Rebecca C , Graham Laura , Idowu Michael O , Wan Wen , Wang Xiang-Yang , Toor Amir A , Bear Harry D , Manjili Masoud H
Published: March 2016

Two major barriers to cancer immunotherapy include tumor-induced immune suppression mediated by myeloid-derived suppressor cells and poor immunogenicity of the tumor-expressing self-antigens. To overcome these barriers, we reprogrammed tumor-immune cell cross-talk by combined use of decitabine and adoptive immunotherapy, containing tumor-sensitized T cells and CD25+ NKT cells. Decitabine functioned to induce the expression of highly immunogenic cancer testis antigens in the tumor, while also reducing the frequency of myeloid-derived suppressor cells and the presence of CD25+ NKT cells rendered T cells, resistant to remaining myeloid-derived suppressor cells. This combinatorial therapy significantly prolonged survival of animals bearing metastatic tumor cells. Adoptive immunotherapy also induced tumor immunoediting, resulting in tumor escape and associated disease-related mortality. To identify a tumor target that is incapable of escape from the immune response, we used dormant tumor cells. We used Adriamycin chemotherapy or radiation therapy, which simultaneously induce tumor cell death and tumor dormancy. Resultant dormant cells became refractory to additional doses of Adriamycin or radiation therapy, but they remained sensitive to tumor-reactive immune cells. Importantly, we discovered that dormant tumor cells contained indolent cells that expressed low levels of Ki67 and quiescent cells that were Ki67 negative. Whereas the former were prone to tumor immunoediting and escape, the latter did not demonstrate immunoediting. Our results suggest that immunotherapy could be highly effective against quiescent dormant tumor cells. The challenge is to develop combinatorial therapies that could establish a quiescent type of tumor dormancy, which would be the best target for immunotherapy.
Is liaison psychiatry effective in primary care?
Authors: Mitchell Alex J.
Published: March 2016

‘Collaborative care’ (involving a case manager) and ‘primary care liaison’ or ‘consultation liaison’ (with no case manager) are models of liaison psychiatry in primary care. Here, I briefly consider the evidence for collaborative care, discuss Gillies et al 's Cochrane review on consultation liaison, and suggest avenues for future study and development of liaison psychiatry in primary care.
Impact of parents' substance misuse on children: an update
Authors: Velleman Richard , Templeton Lorna J.
Published: March 2016

We review how research over the past decade both supports existing knowledge about the risk factors that children in the UK affected by parental substance misuse face, and adds to our knowledge about the protective factors, protective processes and evidence of resilience which can reduce the likelihood that children will experience poor outcomes. Further research is needed to understand what areas of resilience are most important to target and how other variables, such as gender or age, may influence how protective factors affect the development of resilience. Longitudinal research is also needed to better understand how an individual's resilience may change over time. Finally, there remain many considerable challenges which practitioners, service providers, commissioners and policy makers face in better meeting the needs of this population of children.
Severe and enduring somatoform disorders: recognition and management
Authors: Bass Christopher , Pearce Steve
Published: March 2016

Patients with severe and enduring somatoform disorders (SESD) characteristically present with multiple, recurrent and frequently changing physical symptoms that have usually been present for several years before referral to a psychiatrist/psychologist. Many patients report long histories of contact with both primary and tertiary care services, have undergone repeated fruitless investigations and have high levels of disability. SESD are responsible for disproportionately high healthcare costs and are the third most common cause of workplace absence. Identification of patients with SESD by psychiatrists requires particular skills: collaboration with colleagues is vital and there are risks of iatrogenic harm. We describe the obstacles encountered in identifying these patients as well as methods of assessment and management. Treatment pathways best suited to managing this large and as yet untended group of patients are described.
Kaleidoscope
Authors: Tracy Derek K. , Joyce Dan W. , Shergill Sukhwinder S.
Published: March 2016

Friedman's statement that ‘most people who are violent are not
mentally ill, and most people who are mentally ill are not violent’
remains apposite, but recent US gun killings inevitably reawaken the
debate. In a moving editorial in the New England Journal
of Medicine, Malina and colleagues compellingly compare gun
lobbyists to a cancer growing in the mutated cells of the psychological and
sociological make-up of the United States. What is the contribution of
mental health to this problem? Estimates suggest it might have impacted the
trajectory of 3–5% of the approximately 33 000 US gun deaths in 2013. Sadly,
one imagines that psychiatry had a far bigger role in terms of the
subsequent psychological impact on their relatives, witnesses of the
violence, and the further 84 000 who survived such assaults that year.
Against the backdrop of halting convulsions towards legislative change, the
authors reason that mental healthcare cannot be held responsible for what
they label the impossible task of identifying anyone who might conceivably
start shooting others.
Detection of Occult Micrometastases in Patients With Clinical Stage I Non–Small-Cell Lung Cancer: A Prospective Analysis of Mature Results of CALGB 9761 (Alliance)
Authors: Martin Linda W. , D’Cunha Jonathan , Wang Xiaofei , Herzan Debra , Gu Lin , Abraham Naif , Demmy Todd L. , Detterbeck Frank C. , Groth Shawn S. , Harpole David H. , Krasna Mark J. , Kernstine Kemp , Kohman Leslie J. , Patterson G. Alexander , Sugarbaker David J. , Vollmer Robin T. , Maddaus Michael A. , Kratzke Robert A.
Published: March 2016

Purpose

Outcomes after resection of stage I non–small-cell lung cancer (NSCLC) are variable, potentially due to undetected occult micrometastases (OM). Cancer and Leukemia Group B 9761 was a prospectively designed study aimed at determining the prognostic significance of OM.

Materials and Methods

Between 1997 and 2002, 502 patients with suspected clinical stage I (T1-2N0M0) NSCLC were prospectively enrolled at 11 institutions. Primary tumor and lymph nodes (LNs) were collected and sent to a central site for molecular analysis. Both were assayed for OM using immunohistochemistry (IHC) for cytokeratin (AE1/AE3) and real-time reverse transcriptase polymerase chain reaction (RT-PCR) for carcinoembryonic antigen.

Results

Four hundred eighty-nine of the 502 enrolled patients underwent complete surgical staging. Three hundred four patients (61%) had pathologic stage I NSCLC (T1, 58%; T2, 42%) and were included in the final analysis. Fifty-six percent had adenocarcinomas, 34% had squamous cell carcinomas, and 10% had another histology. LNs from 298 patients were analyzed by IHC; 41 (14%) were IHC-positive (42% in N1 position, 58% in N2 position). Neither overall survival (OS) nor disease-free survival was associated with IHC positivity; however, patients who had IHC-positive N2 LNs had statistically significantly worse survival rates (hazard ratio, 2.04, P = .017). LNs from 256 patients were analyzed by RT-PCR; 176 (69%) were PCR-positive (52% in N1 position, 48% in N2 position). Neither OS nor disease-free survival was associated with PCR positivity.

Conclusion

NSCLC tumor markers can be detected in histologically negative LNs by AE1/AE3 IHC and carcinoembryonic antigen RT-PCR. In this prospective, multi-institutional trial, the presence of OM by IHC staining in N2 LNs of patients with NSCLC correlated with decreased OS. The clinical significance of this warrants further investigation.
First-in-Class, First-in-Human Phase I Study of Selinexor, a Selective Inhibitor of Nuclear Export, in Patients With Advanced Solid Tumors
Authors: Abdul Razak Albiruni R. , Mau-Soerensen Morten , Gabrail Nashat Y. , Gerecitano John F. , Shields Anthony F. , Unger Thaddeus J. , Saint-Martin Jean R. , Carlson Robert , Landesman Yosef , McCauley Dilara , Rashal Tami , Lassen Ulrik , Kim Richard , Stayner Lee-Anne , Mirza Mansoor R. , Kauffman Michael , Shacham Sharon , Mahipal Amit
Published: March 2016

Purpose

This trial evaluated the safety, pharmacokinetics, pharmacodynamics, and efficacy of selinexor (KPT-330), a novel, oral small-molecule inhibitor of exportin 1 (XPO1/CRM1), and determined the recommended phase II dose.

Patients and Methods

In total, 189 patients with advanced solid tumors received selinexor (3 to 85 mg/m2) in 21- or 28-day cycles. Pre- and post-treatment levels of XPO1 mRNA in patient-derived leukocytes were determined by reverse transcriptase quantitative polymerase chain reaction, and tumor biopsies were examined by immunohistochemistry for changes in markers consistent with XPO1 inhibition. Antitumor response was assessed according Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 guidelines.

Results

The most common treatment-related adverse events included fatigue (70%), nausea (70%), anorexia (66%), and vomiting (49%), which were generally grade 1 or 2. Most commonly reported grade 3 or 4 toxicities were thrombocytopenia (16%), fatigue (15%), and hyponatremia (13%). Clinically significant major organ or cumulative toxicities were rare. The maximum-tolerated dose was defined at 65 mg/m2 using a twice-a-week (days 1 and 3) dosing schedule. The recommended phase II dose of 35 mg/m2 given twice a week was chosen based on better patient tolerability and no demonstrable improvement in radiologic response or disease stabilization compared with higher doses. Pharmacokinetics were dose proportional, with no evidence of drug accumulation. Dose-dependent elevations in XPO1 mRNA in leukocytes were demonstrated up to a dose level of 28 mg/m2 before plateauing, and paired tumor biopsies showed nuclear accumulation of key tumor-suppressor proteins, reduction of cell proliferation, and induction of apoptosis. Among 157 patients evaluable for response, one complete and six partial responses were observed (n = 7, 4%), with 27 patients (17%) achieving stable disease for ≥ 4 months.

Conclusion

Selinexor is a novel and safe therapeutic with broad antitumor activity. Further interrogation into this class of therapy is warranted.
Effect of Pramlintide on Postprandial Glucose Fluxes in Type 1 Diabetes
Authors: Hinshaw Ling , Schiavon Michele , Dadlani Vikash , Mallad Ashwini , Dalla Man Chiara , Bharucha Adil , Basu Rita , Geske Jennifer R. , Carter Rickey E. , Cobelli Claudio , Basu Ananda , Kudva Yogish C.
Published: March 2016

Context:

Early postprandial hyperglycemia and delayed hypoglycemia remain major problems in current management of type 1 diabetes (T1D).

Objective:

Our objective was to investigate the effects of pramlintide, known to suppress glucagon and delay gastric emptying, on postprandial glucose fluxes in T1D.

Design:

This was a single-center, inpatient, randomized, crossover study.

Patients:

Twelve patients with T1D who completed the study were analyzed.

Interventions:

Subjects were studied on two occasions with or without pramlintide. Triple tracer mixed-meal method and oral minimal model were used to estimate postprandial glucose turnover and insulin sensitivity (SI). Integrated liver insulin sensitivity was calculated based on glucose turnover. Plasma glucagon and insulin were measured.

Main Outcome Measure:

Glucose turnover and SI were the main outcome measures.

Results:

With pramlintide, 2-hour postprandial glucose, insulin, glucagon, glucose turnover, and SI indices showed: plasma glucose excursions were reduced (difference in incremental area under the curve [iAUC], 444.0 mMmin, P = .0003); plasma insulin concentrations were lower (difference in iAUC, 7642.0 pMmin; P = .0099); plasma glucagon excursions were lower (difference in iAUC, 1730.6 pg/mlmin; P = .0147); meal rate of glucose appearance was lower (difference in iAUC: 1196.2 μM/kg fat free mass [FFM]; P = .0316), endogenous glucose production was not different (difference in iAUC: −105.5 μM/kg FFM; P = .5842), rate of glucose disappearance was lower (difference in iAUC: 1494.2 μM/kg FFM; P = .0083). SI and liver insulin sensitivity were not different between study visits (P > .05).

Conclusions:

Inhibition of glucagon and gastric emptying delaying reduced 2-hour prandial glucose excursions in T1D by delaying meal rate of glucose appearance.
Broken Melodies and Deep Grooves: Listening at the Limits of Cuban Music in Miami
Authors: Delgado Celeste Fraser
Published: March 2016

This essay, a response to Alexandra T. Vazquez's Listening in Detail: Performances of Cuban Music (Duke, 2013), follows Vazquez's lead to “listen in detail” to two ongoing musical projects, conceived and executed in the Little Havana nightclub known as Hoy Como Ayer, that dismantle popular Cuban musical forms and reinvent not only Cuban music but US popular music as well. The broken melodies of composer and violinist Alfredo Triff and the deep groove of the Spam Allstars, a jam band that draws from Cuban son, classic soul, and Miami Bass, deterritorialize Cuban music from fixed national imaginaries and reterritorialize an alternative Cuban repertoire within the forever-shifting imaginary of Miami.
Una escuela rara: Feminist Methodologies, Innovation, and the Sound of What Is to Come in Diaspora Studies
Authors: Pinto Samantha
Published: March 2016

This essay argues that there has been a subtle revolution in African diaspora studies that is emerging across very recent scholarship. Alexandra T. Vazquez's Listening in Detail: Performances of Cuban Music (Duke, 2013) is part of a larger movement in the field of black diaspora studies, not only toward sound studies but toward feminist studies. Vazquez's work, alongside that of Edwin Hill, Shana Redmond, and Tsitsi Jaji (among others), pushes black cultural studies in new directions via feminist inquiry and methodologies, as well as via the basic inclusion of women as subjects/authors/performers of African diaspora culture. This scholarship is remaking the field as feminist in innovative and surprising ways, challenging scholars and students to ask questions about audience, circulation, authorship, and activism that embrace more capacious definitions of black cultural production and its global significance.
T'rough Accident: Utterance and Evolution in Songs of Jamaica
Authors: Benson Alex
Published: March 2016

Claude McKay's “Cudjoe Fresh from de Lecture” first saw print in his 1912 volume Songs of Jamaica. Its speaker, whose voice appears in a densely patterned representation of Jamaican Creole, meditates on biological variation and colonial history. Setting the poem against discourses of race and poetics in contemporaneous Kingston print culture (and other intertexts, from Paul Laurence Dunbar's “When Malindy Sings” to Erving Goffman's “The Lecture”), this essay links the thematic concerns of “Fresh from de Lecture” with its medium: McKay, it argues, uses the principle of accident to explore the intersection of evolution, history, and poetic performance. In many accounts of McKay's early work, scholars have read “Fresh from de Lecture” as evidence of McKay's youthful internalization of imperialist apologism and formal conservatism. Conversely, this essay highlights the poem's political intractability—its ironization of social evolutionism, its allusions to insurrection, its emphasis on the counterfactual—and suggests that it offers a surprising view of dialect poetry, one that foregrounds the potentially radical mutations involved in the act of reading aloud.
“That Area of Experience That We Term the New World”: Introducing Sylvia Wynter's “Black Metamorphosis”
Authors: Kamugisha Aaron
Published: March 2016

This essay introduces Sylvia Wynter's “Black Metamorphosis: New Natives in a New World,” an unpublished 900-plus-page manuscript written by Wynter in the 1970s. “Black Metamorphosis” is a remarkable manuscript, and it deserves close study for a number of reasons. It is arguably the most important unpublished nonfiction work by an anglophone Caribbean intellectual and is the major guide to the transition in Wynter's thought between her work mainly on the Caribbean and black America in the 1960s and 1970s and her theory of the human from the early 1980s onward. Not only does the manuscript clarify Wynter's reflections on the process of indigenization and black cultural nationalism, it is her most sustained discussion of the politics of black culture in America. It constitutes a highly significant contribution to the black radical tradition and one of the most compelling interpretations of the black experience in the Western hemisphere ever written by a Caribbean intellectual.
Marronnons Let's Maroon: Sylvia Wynter's “Black Metamorphosis” As a Species of Maroonage
Authors: Thomas Greg
Published: March 2016

This essay reads Sylvia Wynter's “Black Metamorphosis” as a text that both examines and embodies maroonage, significantly, in various ways and on various levels. It takes off from Aimé Césaire's underacknowledged imperative, “Marronnons-nous,” recognizing and demonstrating the import of Césaire's work for Wynter's own work over time. The argument is that “Black Metamorphosis” makes a contribution to the study of maroonage narrowly construed, while also transcending the ironically narrow conception of maroonage as a bound empirical reference. The manuscript speaks of “species of maroonage” and represents one such species itself as an epic political project of African/diasporic resistance anchored all across the Americas.
Sylvia Wynter's Theory of the Human and the Crisis School of Caribbean Heteromasculinity Studies
Authors: Haynes Tonya
Published: March 2016

This essay traces the rise of the crisis school of Caribbean heteromasculinity studies through a critical reading across popular writing, policy research, and scholarly work on Caribbean masculinity. Mobilizing insights that Sylvia Wynter articulated in “Black Metamorphosis” and developed in later essays, it examines the circulation of knowledge on gender and sexuality emanating from the crisis school. Highlighting the points of convergence found in government-sponsored policy studies, academic scholarship, and the newspaper column of a men's organization from Barbados, the essay reveals a particular investment in a specific way of being human and questions what such investments mean for black liberation, gender relations, and power/knowledge.
Building and re-building the heart by cardiomyocyte proliferation
Authors: Foglia Matthew J. , Poss Kenneth D.
Published: March 2016

The adult human heart does not regenerate significant amounts of lost tissue after injury. Rather than making new, functional muscle, human hearts are prone to scarring and hypertrophy, which can often lead to fatal arrhythmias and heart failure. The most-cited basis of this ineffective cardiac regeneration in mammals is the low proliferative capacity of adult cardiomyocytes. However, mammalian cardiomyocytes can avidly proliferate during fetal and neonatal development, and both adult zebrafish and neonatal mice can regenerate cardiac muscle after injury, suggesting that latent regenerative potential exists. Dissecting the cellular and molecular mechanisms that promote cardiomyocyte proliferation throughout life, deciphering why proliferative capacity normally dissipates in adult mammals, and deriving means to boost this capacity are primary goals in cardiovascular research. Here, we review our current understanding of how cardiomyocyte proliferation is regulated during heart development and regeneration.
Archaea box C/D enzymes methylate two distinct substrate rRNA sequences with different efficiency
Authors: Graziadei Andrea , Masiewicz Pawel , Lapinaite Audrone , Carlomagno Teresa
Published: March 2016

RNA modifications confer complexity to the 4-nucleotide polymer; nevertheless, their exact function is mostly unknown. rRNA 2′-O-ribose methylation concentrates to ribosome functional sites and is important for ribosome biogenesis. The methyl group is transferred to rRNA by the box C/D RNPs: The rRNA sequence to be methylated is recognized by a complementary sequence on the guide RNA, which is part of the enzyme. In contrast to their eukaryotic homologs, archaeal box C/D enzymes can be assembled in vitro and are used to study the mechanism of 2′-O-ribose methylation. In Archaea, each guide RNA directs methylation to two distinct rRNA sequences, posing the question whether this dual architecture of the enzyme has a regulatory role. Here we use methylation assays and low-resolution structural analysis with small-angle X-ray scattering to study the methylation reaction guided by the sR26 guide RNA from Pyrococcus furiosus. We find that the methylation efficacy at sites D and D′ differ substantially, with substrate D′ turning over more efficiently than substrate D. This observation correlates well with structural data: The scattering profile of the box C/D RNP half-loaded with substrate D′ is similar to that of the holo complex, which has the highest activity. Unexpectedly, the guide RNA secondary structure is not responsible for the functional difference at the D and D′ sites. Instead, this difference is recapitulated by the nature of the first base pair of the guide-substrate duplex. We suggest that substrate turnover may occur through a zip mechanism that initiates at the 5′-end of the product.
Consumidor de serviços públicos : dever de indenizá-lo enquanto cidadão
Authors: Lazzarini Álvaro
Published: March 2016

1. Considerações de ordem constitucional federal - 1. 1 O artigo 22 do Código de Defesa do Consumidor - 2. Órgãos Públicos - 2. 1 Execução dos Serviços Públicos - 3. Serviços adequados, eficientes, seguros e, quando essenciais, contínuos - 4. Conclusão.
O nexo de casualidade na responsabilidade patrimonial do Estado
Authors: Siqueira Bruno Luiz Weiler
Published: March 2016

1. Introdução. 2. Considerações Gerais. 2. 1. Fundamento da Responsabilidade Estatal. 2.2. Evolução Histórica da Responsabilidade Patrimonial do Estado. 3. Nexo de Causalidade. 3.1. Causas Excludentes e Atenuantes da Responsabilidade do Estado. 3.1.1. Força Maior. 3.1.2. Culpa Exclusiva da Vítima ou de Terceiro. 3.1.3. Culpa Concorrente da Vítima ou de Terceiro. 3.2. Dano Reparável. 3.3. Responsabilidade Objetiva do Estado. 4. Conclusão.
Uma releitura do poder de modificação unilateral dos contratos administrativos no âmbito das concessões de serviços públicos
Authors: Guimarães Fernando Vernalha
Published: March 2016

1. Introdução. - 2. Concessão de serviço público e alteração de normas regulamentares. - 3. "Ius variandi" e reserva de lei. - 4. Natureza do "poder" de instabilização do contrato. - 5. Formação de autoridade do "ius variandi". 6. Intangibilidade da equação econômico-financeira do contrato. - 7. Pressupostos do "ius variandi" - Conclusão - Bibliografia.
Tribunal de contas : um desconhecido na República
Authors: Lins Neto Jair
Published: March 2016

1. Palavras iniciais. - 2. Colocações Preliminares a Propósito do Tema. - 3. Os Tribunais de Contas na Atual Ordem Constitucional. Princípios introdutórios - 4. Atribuições Específicas das Cortes de Contas no Vigente Ordenamento Constitucional. Cotejo com as Disposições Pertinentes da Constituição de 1967. - 5. À Guisa de Conclusão: Breves Considerações Acerca da Pretendida Extinção dos Tribunais de Contas.
Desestatização do sistema Telebrás : Direito de voto em separado na eleição de membros do conselho de administração
Authors: Canto Carlos Alberto Alvahydo de Ulhôa
Published: March 2016

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Concessões de serviços públicos de limpeza urbana
Authors: Justen Filho Marçal
Published: March 2016

I - Apresentação - II. - Breve consideração sobre o conceito de "serviço público" - III. O serviço público de coleta e destinação final de lixo - IV. - Concessão dos serviços públicos de limpeza urbana - IV.I. - Serviços delegáveis a particulares - IV.2 - Remuneração pela prestação específica do serviço - V. - Competência legislativa e administrativa para a disciplina e a concessão dos serviços de limpeza urbana - VI. - Contraprestação pelos serviços de limpeza urbana nos regimes de concessão e de contratação de serviços - VII. - Destinação específicade receita de imposto - VIII. - Conclusões.
Comissão Parlamentar de Inquérito - Prerrogativas do advogado - Imunidade profissional
Authors: Mello Celso Antônio Bandeira de
Published: March 2016

-Os poderes das Comissões Parlamentares de Inquérito, embora amplos, não são ilimitdos e nem absolutos.- O advogado, por dispor de imunidade profissional reconhecida em lei, goza de prerrogativa que lhe outorga, em razão do ofício, o art. 7º, §2º da Lei nº 8.906/94.EMENTA: COMISSÃO PARLAMENTAR DE INQUÉRITO. ADVOGADO. DIREITO DE VER RESPEITADAS AS PRERROGATIVAS DE ORDEM PROFISSIONAL INSTITUÍDAS PELA LEI Nº 8.906/94. MEDIDA LIMINAR CONCEDIDA.
Parlamentares - Prerrogativa de foro - Ação civil pública
Authors: Mello Celso Antônio Bandeira de
Published: March 2016

- O Supremo Tribunal Federal qualifica-se como juiz natural dos membros do Congresso Nacional nas estritas hipóteses de infrações penais.- O Supremo Tribunal Federal não tem competência originária para processar e julgar ações civis públicas ainda que se trate de pessoas ou autoridades com prerrogativa de foro nos casos estritos de "crimes comuns ".EMENTA: SENADOR DA REPÚBLICA. INQUÉRITO CIVIL. AÇÃO CIVIL PÚBLICA. MEDIDA PROCESSUAL A SER EVENTUALMENTE ADOTADA CONTRA EMPRESAS QUE ESTNERAM SUJEITAS AO PODER DE CONTROLE E GESTÃO DO PARLAMENTAR, ATÉ A SUA INVESTIDURA NO MANDADO LEGISLATNO. ALEGADA USURPAÇÃO DA COMPETÊNCIA ORIGINÁRIA DO SUPREMO TRIBUNAL FEDERAL. AUSÊNCIA DE PLAUSIBILIDADE JURÍDICA. MEDIDA LIMINAR CASSADA.
Medida provisória - Uso abusivo - Matéria tributária
Authors: Mello Celso Antônio Bandeira de
Published: March 2016

- Crítica ao uso abusivo da Medida Provisória.- Cabimento em matéria tributária segundo jurisprudência dominanteno Supremo Tribunal Federal.- Termo inicial do prazo do art. 195, § 6º da Constituição Federal.EMENTA: CONTRIBUIÇÕES SOCIAIS. NATUREZA TRIBUTÁRIA. ,MAJORAÇÃO. MEDIDA PROVISÓRIA. ORIENTAÇÃO PREDOMINANTE NO SUPREMO TRIBUNAL FEDERAL. POSIÇÃO PESSOAL DO RELATOR: gravidade da utilização imoderada do poder excepcional de editar medidas provisórias como instrumento usual de prática legislativa pelo Presidente da República. TRATAMENTO CONSTITUCIONAL DO TEMA NO DIREITO COMPARADO. CONTRIBUIÇÃO DE SEGURIDADE SOCIAL. PRINCÍPIO DA ANTERIORIDADE ESPECIAL OU MITIGADA. TERMO INICIAL DO PRAZO A QUE SE REFERE O ART. 195, § 62, DA CONSTITUIÇÃO. PRECEDENTES.
Recurso extraordinário - Professor titular - Concurso público
Authors: Batista Wagner Natal
Published: March 2016

EMENTA: Magistério público superior. Exigência de concurso público de provas e de títulos para o cargo de professor titular. Constitucionalidade. - O artigo 206, V, da atual Constituição não proíbe que, no magistério público superior, a legislação infraconstitucional (inclusive as normas regulamentares das Universidades) estabeleça carreira até o cargo de professor adjunto e considere como cargo isolado o de professor, fazendo depender o ingresso nele de concurso de provas e de títulos. Assim, não se pode pretender que a legislação ordinária anterior à Constituição de 1988, que, em última análise, dispunha sobre a carreira até o cargo de professor adjunto e tinha como cargo isolado, por imposição do sistema constitucional anterior, o de professor titular, exigindo para o ingresso nele concurso de provas e de títulos, haja sido revogada pela atual Carta Magna.- inexistência, no caso, de ofensa ao princípio constitucional da autonomia universitária.Recurso extraordinário conhecido, mas não provido.
Emenda Constitucional - Reforma do Poder Judiciário Estadual - Inconstitucionalidade
Authors: Martins Ives Gandra da Silva
Published: March 2016

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Serviços de construção civil - ISS - Isenção
Authors: Martins Ives Gandra da Silva
Published: March 2016

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Mandado de Segurança - Tutela antecipada - Consumidor inadimplente
Authors: Ferreira Sergio de Ándrea
Published: March 2016

- Mandado de Segurança como ação de impugnação de processo impróprio, ajuizado em justiça incompetente por parte ilegítima.- Ilegalidade de concessão de tutela antecipada para vedar suspensão de fornecimento de energia elétrica a consumidor inadimplente.
Invalidação dos atos administrativos
Authors: Vitta Heraldo Garcia
Published: March 2016

Sumário. I - Introdução. II - Conceito de Ato Administrativo. III - Perfeição. Validade e Eficácia do Ato. IV - Extinção dos Atos Administrativos. V - Invalidade dos Atos Administrativos. v. I - Conceito de Invalidação. v.2 -Classificação das invalidades. v.2.1 - Atos Inexistentes. v.2.2 - Atos Nulos e Anuláveis. v.2.3 - Atos Irregulares. v.3 - Os Efeitos dos Atos Inválidos. VI - Os Elementos ou Requisitos do Ato Administrativo e a Invalidação. VII - Conclusões. VIII - Bibliografia.
A taxa SELIC para correção de débitos tributários
Authors: Martins Ives Gandra da Silva
Published: March 2016

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A administração Pública em face da responsabilidade ambiental
Authors: Mukai Toshio
Published: March 2016

I - Introdução - II- A Administração em face da responsabilidade administrativa do poluidor (ou eventual) - a) - o controle prévio através do licenciamento ambiental - b) - o estudo de impacto ambiental, novas regras - c) - as sanções administrativas - III - A administração Pública e a responsabilidade civil (objetiva) do poluidor - IV- A responsabilidade ou criminalização dos atos danosos ao meio ambiente - As recentes sanções penais - V - Comunicabilidade e incomunicabilidade das instâncias penais, administrativas e civil.
Eficiência administrativa na Constituição Federal
Authors: França Vladimir da Rocha
Published: March 2016

1. Introdução. 2. Elementos para a caracterização da eficiência administrativa como princípio. 3. Conteúdo jurídico da eficiência administrativa. 4. Aspectos polêmicos do controle judicial da eficiência administrativa. 5. Notas finais. Referências Bibliográficas.
Princípio do fato consumado no direito administrativo
Authors: Mattos Mauro Roberto Gomes de
Published: March 2016

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Ministério Público - Férias em dobro - Constitucionalidade
Authors: Brindeiro Geraldo
Published: March 2016

- Direito de membros do Ministério Público Estadual do Rio Grande do Sul a dois meses de férias anuais, segundo o art. 51 da Lei federal nº 8.625/93 que declara igualdade às férias dos magistrados.- Inconstitucionalidade da Lei estadual nº 8.874/89 quando fixa período de férias calculado sobre a remuneração mensal.EMENTA: ESTADO DO RIO GRANDE DO SUL. LEI N. 8.874, DE 18.07.89, QUE LIMITA A APENAS UM MÊS DE FÉRIAS O AUMENTO, EM 30%, DOS VENCIMENTOS DOS MEMBROS DO MINISTÉRIO PÚBLICO ESTADUAL, PREVISTO NO ART. 7º , XVII, DA CONSTITUIÇÃO.
Controle de constitucionalidade - Constituição Estadual - Constituição Federal
Authors: Pertence José Paulo Sepúlveda
Published: March 2016

- No julgamento de ação de inconstitucionalidade de lei estadual a coincidência de ações propostas perante o Tribunal de Justiça e o Supremo Tribunal Federal sob o fundamento de violação de normas da constituição Federal reproduzidas na constituição Estadual, prevalece a competência do Supremo Tribunal Federal.- Todavia, se a ação proposta perante a Justiça Estadual envolve preceitos de lei estadual não abrangidas na ação proposta perante o Supremo Tribunal Federal, é válida a competência do Tribunal de Justiça do Estado para decidir sobre esta matéria adicional.
Imunidade parlamentar - Indiciado - Testemunha
Authors: Mello Celso Antônio Bandeira de
Published: March 2016

- A imunidade parlamentar prevista no art. 22 I do Código de Processo Penal protege os parlamentares na qualidade de testemunha e não se aplica ao indiciado ou réu.
Seguro-saúde - Contribuição - Alíquota
Authors: Borja Célio de Oliveira
Published: March 2016

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Estado - Entidade de previdência de servidores públicos - Imunidade tributária
Authors: Ferreira Sergio de Ándrea
Published: March 2016

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O princípio da razoabilidade da lei - Limites da função legislativa
Authors: Silva José Afonso da
Published: March 2016

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Emenda Constitucional, Leis, Leis Complementares, Razões de veto, Medida Provisória e Decretos (2000)
Authors: Desconhecido Desconhecido
Published: March 2016

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Agências reguladoras da administração
Authors: Tácito Caio
Published: March 2016

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Constitucionalidade/Inconstitucionalidade : uma questão política ?
Authors: Coelho Inocêncio Mártires
Published: March 2016

1. Colocação do tema; 2. A distinção entre regras e princípios e a sua relevância para a interpretação constitucional; 3. Métodos e princípios da interpretação constitucional; 4. Constitucionalidade e inconstitucionalidade: uma questão política; 5. Conclusão.
A inconstitucionalidade da lei estadual que concede gratuidade no transporte coletivo intermunicipal
Authors: Netto André Luiz Borges
Published: March 2016

1. - Introdução - 2. - A desvaliajurídica da lei estadual nº 1.355/93 - 3. - Conclusão
Vencimento - Correção monetária - Substituição processual
Authors: Brindeiro Geraldo
Published: March 2016

CONSTITUCIONAL ADMINISTRATIVO. PROCESSUAL CIVIL SUPREMO TRIBUNAL FEDERAL: COMPETÊNCIA ORIGINÁRIA: C. F., art. 102, I, n. AÇÃO ORDINÁRIA COLETIVA: LEGITIMAÇÃO: ENTIDADE DE CLASSE: AUTORIZAÇÃO EXPRESSA: C.F., art. 5D , XXI. SERVIDOR PÚBLICO: REMUNERAÇÃO: CORREÇÃO MONETÁRIA. I. - Ação ordinária em que magistrados do Rio Grande do Sul pleiteiam correção monetária sobre diferença de vencimentos paga com atraso. Interesse geral da magistratura gaúcha no desfecho da ação. Competência originária do Supremo Tribunal Federal: C.F., art. 102, I, n.II. - Ação ordinária coletiva promovida por entidade de classe: C.F., art. 5D , XXI: in exigência de autorização expressa dos filiados. Voto vencido do Relator: aplicabilidade da regra inscrita no art. 5D , XXI, da C.F.: necessidade de autorização expressa dos filiados, não bastando cláusula autorizativa constante do Estatuto da entidade de classe.III. - Diferença de vencimentos paga com atraso: cabimento da correção monetária, tendo em vista a natureza alimentar de salários e vencimentos. Precedentes do S. T.F. IV. - Ação conhecida e julgada procedente.
Comissão Parlamentar de Inquérito - Depoente - Direito ao silêncio
Authors: Brindeiro Geraldo
Published: March 2016

I. Se, conforme o art. 58, § 30, da Constituição, as comissões parlamentares de inquérito detêm o poder instrutório das autoridades judiciais - e não maior que o dessas - a elas se poderão opor os mesmos limites formais e substanciais oponíveis aos juízes, dentre os quais os derivados das garantias constitucionais contra a auto-incriminação, que tem sua manifestação mais eloqüente no direito ao silêncio dos acusados. Não importa que, na CPI - que tem poderes de instrução, mas nenhum poder de processar nem de julgar -, a rigor não haja acusados: a garantia contra a auto-incriminação se estende a qualquer indagação por autoridade pública de cuja resposta possa advir à imputação ao declarante da prática de crime, ainda que em procedimento e foro diversos. Se o objeto da CPI é mais amplo do que os fatos em relação aos quais o cidadão intimado a depor tem sido objeto de suspeitas, do direito ao silêncio não decorre o de recusar-se de logo a depor, mas sim o de não responder às perguntas cujas repostas entenda possam vir a incriminá-lo: liminar deferida para que, comparecendo à CPI, nesses termos, possa o paciente exercê-lo, sem novamente ser preso ou ameaçado de prisão.II. Habeas corpus prejudicado, uma vez observada a liminar na volta do paciente à CPI e já encerrados os trabalhos dessa.
Juros reais - Limite - Lei complementar
Authors: Almeida João Batista de
Published: March 2016

A regra inscrita no art. 192, § 3°, da Carta Política - norma constitucional de eficácia limitada - constitui preceito de integração que reclama, em caráter necessário, para efeito de sua plena incidência, a mediação legislativa concretizadora do comando nela positivado. Ausente a lei complementar reclamada pela Constituição, não se revela possível a aplicação imediata da taxa de juros reais de 12% a.a. prevista no art. 192, § 3º, do texto constitucional.
Pena de multa - Processo criminal - Competência
Authors: Saraiva Filho Oswaldo Othon de Pontes
Published: March 2016

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Leiloeiro oficial - Junta comercial - Poderes
Authors: Rodrigues Sônia Maria de Menezes
Published: March 2016

- Com o advento da Lei n° 8.934/94 não cabe poderes às Juntas Comerciais para a realização de concurso ou outros procedimentos para o exercício da profissão de leiloeiro oficial, apenas o sistema de matrícula e seu cancelamento.
Sociedade de economia mista - Subsidiária - Contratos
Authors: Tácito Caio
Published: March 2016

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Poder de sanção - Órgão regulador - ANEEL
Authors: Marques Neto Floriano de Azevedo
Published: March 2016

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Sociedade de economia mista - Sócio estratégico - Acordo de acionistas
Authors: Dallari Adilson Abreu
Published: March 2016

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Leis, Leis Complementares, Anexo à Lei Complementar, Razões de vetos, Decretos e Emendas Constitucionais (2000)
Authors: Desconhecido Desconhecido
Published: March 2016

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A efetividade do princípio da manutenção do valor real dos benefícios previdenciários
Authors: Carvalho Maria Amélia Almeida Jenos de
Published: March 2016

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Vinculação e discricionariedade nos atos administrativos
Authors: França Vladimir da Rocha
Published: March 2016

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Controle de Constitucionalidade: modelos brasileiro e italiano (Breve análise comparativa)
Authors: Nobre Junior Edilson Pereira
Published: March 2016

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Pregão: Nova modalidade de licitação
Authors: Vasconcellos Pedro Barreto
Published: March 2016

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Operação Interligada - Competência do Prefeito - Ato negociaI
Authors: Ferreira Sérgio de Andréa
Published: March 2016

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Do Equilíbrio econômico-financeiro do contrato de concessão
Authors: Wald Arnoldo
Published: March 2016

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Concessão de rodovias - Código do Consumidor - Ação Civil Pública
Authors: Moreira Egon Bockmann
Published: March 2016

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Leis, Decretos-leis e Decretos (2000)
Authors: Desconhecido Autor
Published: March 2016

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Universalização de serviços públicos e competição - O caso da distribuição de gás natural
Authors: Marques Neto Floriano Peixoto de Azevedo
Published: March 2016

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Comentário
Authors: Gordilho Pedro
Published: March 2016

Comentário sobre o artigo "Desapropriação - Procedimento administrativo - Medida cautelar suspensiva".
Servidores da justiça - Servidor público - Aposentadoria compulsória
Authors: Velloso Carlos Mario da Silva
Published: March 2016

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Aposentadoria - Arredondamento do tempo de serviço - Utilidade
Authors: Rodrigues Walton Alencar
Published: March 2016

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Portaria n° 44, de 20 de fevereiro de 200 1
Authors: Barbosa Fábio de Oliveira
Published: March 2016

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Teto de remuneração - Vantagem pessoal- Exclusão
Authors: Macêdo Wilson Teles de
Published: March 2016

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A participação de cooperativas nas licitações da Administração Pública
Authors: Becho Renato Lopes
Published: March 2016

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O direito ambiental no Brasil: evolução histórica e a relevância do direito internacional do meio ambiente
Authors: Mukai Toshio , Nazo Georgette N.
Published: March 2016

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Impacto da globalização sobre o princípio da eficiência
Authors: Barbosa Sandra Pires
Published: March 2016

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Os direitos sociais e a teoria discursiva do direito
Authors: Mello Cláudio Ari
Published: March 2016

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Ensaio sobre o conteúdo jurídico do princípio da lucratividade
Authors: Scaff Fernando Facury
Published: March 2016

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Ordem dos Advogados - Tribunal de Contas - Inexistência de fiscalização
Authors: Martins Ives Granda da Silva
Published: March 2016

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