bluuebunny/crossref_metadata_2025 huggingface dataset:
Association between retinal sensitivity and the presence of quiescent choroidal neovascularization in pachychoroid diseases
Authors: Ozawa Rion , Azuma Keiko , Nomura Yoko , Murata Hiroshi , Asaoka Ryo , Kitamoto Kohdai , Ueda Kohei , Inoue Tatsuya , Obata Ryo
Published: July 2022

This study was conducted to examine retinal sensitivity (RS) in eyes with pachychoroid diseases and to analyze its association with the presence or absence of quiescent choroidal neovascularization (CNV), that can be protective against retinal dysfunction or atrophy in other macular diseases such as age-related macular degeneration. A total of 12 eyes of 12 patients aged ≥45 years having the characteristic findings of central serous chorioretinopathy but not presenting any exudative changes were included in this study. Choroidal vascular hyper permeability (CVH) was identified by indocyanine green angiography, and the presence or absence of CNV was evaluated by optical coherence tomography angiography. RS at 68 points was examined by microperimetry. The average RS corresponding to within and outside CVH was compared. The association between the difference in RS and the presence or absence of CNV was also analyzed. CNV was detected in six eyes (50%). In eyes without CNV, the RS within CVH was similar compared with that outside CVH. However, in eyes with CNV, the RS within CVH was significantly decreased compared with that outside CVH. Multiple regression analysis revealed the presence of CNV as an independent factor associated with RS. In eyes with pachychoroid diseases, RS decreased within the CVH area under the coexistence of nonexudative CNV.
Prediction models used in the progression of chronic kidney disease: A scoping review
Authors: Lim David K. E. , Boyd James H. , Thomas Elizabeth , Chakera Aron , Tippaya Sawitchaya , Irish Ashley , Manuel Justin , Betts Kim , Robinson Suzanne
Published: July 2022

Objective

To provide a review of prediction models that have been used to measure clinical or pathological progression of chronic kidney disease (CKD).

Design

Scoping review.

Data sources

Medline, EMBASE, CINAHL and Scopus from the year 2011 to 17thFebruary 2022.

Study selection

All English written studies that are published in peer-reviewed journals in any country, that developed at least a statistical or computational model that predicted the risk of CKD progression.

Data extraction

Eligible studies for full text review were assessed on the methods that were used to predict the progression of CKD. The type of information extracted included: the author(s), title of article, year of publication, study dates, study location, number of participants, study design, predicted outcomes, type of prediction model, prediction variables used, validation assessment, limitations and implications.

Results

From 516 studies, 33 were included for full-text review. A qualitative analysis of the articles was compared following the extracted information. The study populations across the studies were heterogenous and data acquired by the studies were sourced from different levels and locations of healthcare systems. 31 studies implemented supervised models, and 2 studies included unsupervised models. Regardless of the model used, the predicted outcome included measurement of risk of progression towards end-stage kidney disease (ESKD) of related definitions, over given time intervals. However, there is a lack of reporting consistency on details of the development of their prediction models.

Conclusions

Researchers are working towards producing an effective model to provide key insights into the progression of CKD. This review found that cox regression modelling was predominantly used among the small number of studies in the review. This made it difficult to perform a comparison between ML algorithms, more so when different validation methods were used in different cohort types. There needs to be increased investment in a more consistent and reproducible approach for future studies looking to develop risk prediction models for CKD progression.
Descriptive transcriptome analysis of tendon derived fibroblasts following in-vitro exposure to advanced glycation end products
Authors: Patel Shivam H. , Mendias Christopher L. , Carroll Chad C.
Published: July 2022

Background

Tendon pathologies affect a large portion of people with diabetes. This high rate of tendon pain, injury, and disease appears to manifest independent of well-controlled HbA1c and fasting blood glucose. Advanced glycation end products (AGEs) are elevated in the serum of those with diabetes. In vitro, AGEs severely impact tendon fibroblast proliferation and mitochondrial function. However, the extent that AGEs impact the tendon cell transcriptome has not been evaluated.

Objective

The purpose of this study was to investigate transcriptome-wide changes that occur to tendon-derived fibroblasts following treatment with AGEs. We propose to complete a descriptive approach to pathway profiling to broaden our mechanistic understanding of cell signaling events that may contribute to the development of tendon pathology.

Methods

Rat Achilles tendon fibroblasts were treated with glycolaldehyde-derived AGEs (200μg/ml) for 48 hours in normal glucose (5.5mM) conditions. In addition, total RNA was isolated, and the PolyA+ library was sequenced.

Results

We demonstrate that tendon fibroblasts treated with 200μg/ml of AGEs differentially express 2,159 gene targets compared to fibroblasts treated with an equal amount of BSA-Control. Additionally, we report in a descriptive and ranked fashion 21 implicated cell-signaling pathways.

Conclusion

Our findings suggest that AGEs disrupt the tendon fibroblast transcriptome on a large scale and that these pathways may contribute to the development and progression of diabetic tendinopathy. Specifically, pathways related to cell cycle progression and extracellular matrix remodeling were affected in our data set and may play a contributing role in the development of diabetic tendon complications.
Inventory of water masses and carbonate system from Brazilian’s northeast coast: Monitoring ocean acidification
Authors: Ramos e Silva Carlos Augusto , Monteiro Nicole Silva Caliman , Cavalcante Luciana Miranda , Junior Waldemar Tavares , Rocha Carneiro Maria Eulália , Soares de Souza Flavo Elano , Borges Garcia Carlos Alexandre , Damasceno Raimundo Nonato , de Araújo Rocha Anderson
Published: July 2022

This manuscript presents an inventory of the carbonate system from the main water masses comprising the marine current system on Brazil’s northeast coast (South Atlantic Ocean). For this purpose, four transects were conducted with an approximate length of 357 km (each one) through the platform and continental slope of the Sergipe–Alagoas sedimentary basin. Water samples were then collected in vertical profiles measuring from 5 to 1,799 meters depth, totaling 34 stations. Total alkalinity, calcium, and total boron were obtained analytically from these samples and by relationships with salinity. Speciation and concentration of the carbonate system were obtained by means of thermodynamic modeling. The results revealed that the empirical models used to calculate the concentrations of TA, calcium and total boron showed relevant variation when compared to the analytical values (TA: 5.0–6.5%; Ca: 0.4–4.8%; BT: 7.0–18.9%). However, the speciation and concentration of the carbonate system (CA, DIC,CO32−, CO2(aq), ΩCalc, and ΩArag) obtained from the empirical values of TA, calcium and total boron did not differ significantly from those obtained analytically (0.0–6.1%). On the other hand, the parameters of pH,HCO3‐,CO3(aq)2‐, CO2(aq), ρCO2, ΩCalc, and ΩAragvaried significantly within the different water masses (p < 0.05). This study supports and encourages acidification monitoring projects in the South Atlantic Ocean, based on modeling the carbonate system parameters generated in real-time.
Fine mapping of the antigenic epitopes of the Gc protein of Guertu virus
Authors: Yusufu Meilipaiti , Abula Ayipairi , Jiang Boyong , Zhumabai Jiayinaguli , Deng Fei , Li Yijie , Zhang Yujiang , Ding Juntao , Sun Surong
Published: July 2022

Guertu virus (GTV), a newly discovered member of the genus Banyangvirus in the family Phenuiviridae, poses a potential health threat to humans and animals. The viral glycoprotein (GP) binds to host cell receptors to induce a neutralizing immune response in the host. Therefore, identification of the B-cell epitopes (BCEs) in the immunodominant region of the GTV Gc protein is important for the elucidation of the virus–host cell interactions and the development of GTV epitope assays and vaccines. In this study, an improved overlapping biosynthetic peptide method and rabbit anti-GTV Gc polyclonal antibodies were used for fine mapping of the minimal motifs of linear BCEs of the GTV Gc protein. Thirteen BCE motifs were identified from eleven positive 16mer-peptides, namely EGc1 (19KVCATTGRA27), EGc2 (58KKINLKCKK66), EGc3 (68SSYYVPDA75), EGc4 (75ARSRCTSVRR84), EGc5 (79CTSVRRCRWA88), EGc6 (90DCQSGCPS97), EGc7 (96PSHFTSNS103), EGc8 (115AGLGFSG121), EGc9 (148ENPHGVI154), EGc10 (179KVFHPMS185), EGc11 (230QAGMGVVG237), EGc12 (303RSHDSQGKIS312), and EGc13 (430DIPRFV435). Of these, 7 could be recognized by GTV IgG-positive sheep sera. Three-dimensional structural analysis revealed that all 13 BCEs were present on the surface of the Gc protein. Sequence alignment of the 13 BCEs against homologous proteins from 10 closely related strains of severe fever with thrombocytopenia syndrome virus from different geographical regions revealed that the amino acid sequences of EGc4, EGc5, EGc8, EGc11, and EGc12 were highly conserved, with 100% similarity. The remaining 8 epitopes (EGc1, EGc2, EGc3, EGc6, EGc7, EGc9, EGc10, and EGc13) showed high sequence similarity in the range of 71.43%–87.50%. These 13 BCEs of the GTV Gc protein provide a molecular foundation for future studies of the immunological properties of GTV glycoproteins and the development of GTV multi-epitope assays and vaccines.
Influences of parental monitoring and school connectedness on age at first sexual debut among unmarried female youth in Bedele town, Ethiopia: A survival analysis of timing using accelerated failure time model
Authors: Debele Gebiso Roba , Tsegaye Dereje , Gemechu Teshale , Siraj Sabit Zenu
Published: July 2022

Background

The age of first sexual debut among youth continues to attract interest as it marks the start of their exposure to a variety of sexual and reproductive health problems. Parental monitoring (PM) and school connectedness (SC) has been found to have an effect on this problem. Despite this fact, there is a dearth of literature on implications of PM and SC on age at first sexual debut in Ethiopia. Therefore, this paper examined the influences of PM and SC age at first sexual debut among female youth.

Methods

A retrospective follow-up study was conducted on 470 randomly selected female youth in Bedele town, Oromia regional state, southwest Ethiopia from February 1 to March 30, 2021. The age at first sexual debut was asked in full years for respondents who ever engaged in sexual debut at a time of data collection. Data were entered using Epi-Data version 4.6 and analyzed using Stata version 14. All variables at P-values less than 0.2 in bivariable analysis were exported to multivariable analysis. Multivariable Accelerated Failure Time (AFT) regression analyses using Weibull distribution were used to examine the association of age at first sexual debut with PM and SC at 5% level of significance.

Results

Overall, 132(28.1%) youths were begun sexual activities of which 79.54% was an early (vaginal penetrative sex before 18 years old). The incidence rate was 15.58/1000 PY with 95% CI of [13.14, 18.47]. The result shows that, female youth start first sexual debut as early as 10 year and mean age was 16.89±2.82. Only 27.97% of those who began sexual debut used contraception during first sex. Multivariable Weibull AFT regression analyses adjusted for different variables showed that high PM (Adjusted Time Ratio (ATR) 1.13: 95%CI; [1.04, 1.21]) and good SC (ATR: 1.14: 95% CI; [1.06, 1.22] significantly delays the age at first sexual debut.

Conclusions

Overall, four out of every five premarital sexual activities were early sexual debuts. High PM and high SC significantly decrease early sexual debut by delaying the age of sexual initiation. Therefore, family and school involvement focused on PM and SC of the youth is recommended as an important mechanism for preventing youths’ risky sexual behaviour, including early sexual debut.
Development of transgenic models susceptible and resistant to SARS-CoV-2 infection in FVB background mice
Authors: Seo Sun-Min , Son Jae Hyung , Lee Ji-Hun , Kim Na-Won , Yoo Eun-Seon , Kang Ah-Reum , Jang Ji Yun , On Da In , Noh Hyun Ah , Yun Jun-Won , Park Jun Won , Choi Kang-Seuk , Lee Ho-Young , Shin Jeon-Soo , Seo Jun-Young , Nam Ki Taek , Lee Ho , Seong Je Kyung , Choi Yang-Kyu
Published: July 2022

Coronavirus disease (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is currently spreading globally. To overcome the COVID-19 pandemic, preclinical evaluations of vaccines and therapeutics using K18-hACE2 and CAG-hACE2 transgenic mice are ongoing. However, a comparative study on SARS-CoV-2 infection between K18-hACE2 and CAG-hACE2 mice has not been published. In this study, we compared the susceptibility and resistance to SARS-CoV-2 infection between two strains of transgenic mice, which were generated in FVB background mice. K18-hACE2 mice exhibited severe weight loss with definitive lethality, but CAG-hACE2 mice survived; and differences were observed in the lung, spleen, cerebrum, cerebellum, and small intestine. A higher viral titer was detected in the lungs, cerebrums, and cerebellums of K18-hACE2 mice than in the lungs of CAG-hACE2 mice. Severe pneumonia was observed in histopathological findings in K18-hACE2, and mild pneumonia was observed in CAG-hACE2. Atrophy of the splenic white pulp and reduction of spleen weight was observed, and hyperplasia of goblet cells with villi atrophy of the small intestine was observed in K18-hACE2 mice compared to CAG-hACE2 mice. These results indicate that K18-hACE2 mice are relatively susceptible to SARS-CoV-2 and that CAG-hACE2 mice are resistant to SARS-CoV-2. Based on these lineage-specific sensitivities, we suggest that K18-hACE2 mouse is suitable for highly susceptible model of SARS-CoV-2, and CAG-hACE2 mouse is suitable for mild susceptible model of SARS-CoV-2 infection.
Clinical profile of HIV-infected adults receiving a holistic approach of care model in Nakawa, Kampala District
Authors: Sendaula Emmanuel , Buwembo Michael , Opio Denis
Published: July 2022

People Living with HIV (PLHIV) are often dealing with a range of issues that make life more difficult because of the limited emotional, spiritual, psychological, social, physical and clinical support which consequently lead to poor physical health and quality of life. The holistic care of individuals infected with HIV/AIDS involves promoting psychological and physiological well-being as well as fostering socio-cultural relationships and supporting the fulfillment of spiritual aspirations. We conducted a retrospective cross-sectional study among HIV-infected patients receiving a holistic approach of care model from January 2015 to December 2018 in Kampala district, Uganda. The study involved adult individuals aged 18 and above from whom demographics and other information were obtained. All eligible participants were selected using stratified random sampling from the parishes and systematic random sampling to select study participants. We investigated the clinical profile and the factors associated with viral load suppression among HIV-infected patients receiving a holistic approach of care model in Kampala District. The data was analyzed using STATA version 13. 0. Results: A total of 910 patients were enrolled. 676 (74.3%) were female; 453 (49.8%) were between 18 and 39 years. 324 (35.6%) were either overweight or obese. 769 (84.5%) had viral load beyond detectable limits, 904 (99.3%) were adhering to HIV treatment. 867(95.3%) were virally suppressed. The age group 40–59 years (Adjusted Odds Ratio (aOR) = 2.85, 95% Confidence Interval (CI):1.36–5.97, P = 0.005) and good adherence (aOR = 12.9, 95%CI:1.86–81.07, P = 0.009) were significantly associated with viral load suppression. Conclusion: The holistic care model supports patients in all facets of their lives, resulting into improved treatment outcomes. Our findings show that age and adherence are linked to viral load suppression among HIV-infected adults receiving a holistic approach of care model.
Association between visceral fat and influenza infection in Japanese adults: A population-based cross-sectional study
Authors: Kinoshita Keita , Ozato Naoki , Yamaguchi Tohru , Mori Kenta , Katsuragi Yoshihisa , Yasukawa Takuji , Murashita Koichi , Nakaji Shigeyuki , Ihara Kazushige
Published: July 2022

Background

Several studies have reported that obesity is associated with influenza infection; however, the role of visceral fat remains unclear. The aim of this study was to investigate the association between visceral fat and influenza infection in community-dwelling Japanese adults.

Methods

A cross-sectional study was performed using data from an annual community-based health check-up conducted from May to June in 2019. In total, 1,040 Japanese adults aged 20–89 years were enrolled in this study. Influenza infection status was determined by participants’ responses to a self-administered questionnaire. The visceral fat area (VFA) was measured using a bioimpedance-type visceral fat meter. Participants were classified into four groups using the following cut-off points: VFA < 100 cm2 was set as the reference category according to the Japanese criteria, 100 ≤ VFA < 150 cm2, 150 ≤ VFA < 200 cm2, and 200 cm2 ≤ VFA. Logistic regression models were used to assess the association between VFA and influenza infection.

Results

In total, 119 participants had influenza infections in the past year. In the multivariate adjusted model, a higher VFA was significantly associated with increased influenza infection; the adjusted odds ratio for 200 cm2 ≤ VFA was 5.03 [95% confidence interval (CI): 1.07–23.6], that for 150 ≤ VFA < 200 cm2 was 1.97 (95% CI: 0.71–5.45), and that for 100 ≤ VFA < 150 cm2 was 1.62 (95% CI: 0.84–3.12), compared with that for VFA < 100 cm2 (p for trend = 0.049). These findings were confirmed in the same cohort the following year.

Conclusions

Our results suggest that visceral fat accumulation is associated with influenza infection. Large-scale prospective studies using diagnostic information for influenza infection are required to confirm this association.
Morally excused but socially excluded: Denying agency through the defense of mental impairment
Authors: de Vel-Palumbo Melissa , Ferguson Rose , Schein Chelsea , Chang Melissa Xue-Ling , Bastian Brock
Published: July 2022

Defendants can deny they have agency, and thus responsibility, for a crime by using a defense of mental impairment. We argue that although this strategy may help defendants evade blame, it may carry longer-term social costs, as lay people’s perceptions of a person’s agency might determine some of the moral rights they grant them. Three randomized between-group experiments (N = 1601) used online vignettes to examine lay perceptions of a hypothetical defendant using a defense of mental impairment (versus a guilty plea). We find that using a defense of mental impairment significantly reduces responsibility, blame, and punitiveness relative to a guilty plea, and these judgments are mediated by perceptions of reduced moral agency. However, after serving their respective sentences, those using the defense are sometimes conferred fewer rights, as reduced agency corresponds to an increase in perceived dangerousness. Our findings were found to be robust across different types of mental impairment, offences/sentences, and using both manipulated and measured agency. The findings have implications for defendants claiming reduced agency through legal defenses, as well as for the broader study of moral rights and mind perception.
Glycine-serine-rich effector PstGSRE4 in Puccinia striiformis f. sp. tritici inhibits the activity of copper zinc superoxide dismutase to modulate immunity in wheat
Authors: Liu Cong , Wang Yunqian , Wang Yanfeng , Du Yuanyuan , Song Chao , Song Ping , Yang Qian , He Fuxin , Bai Xingxuan , Huang Lili , Guo Jia , Kang Zhensheng , Guo Jun
Published: July 2022

Puccinia striiformis f. sp. tritici (Pst) secretes an array of specific effector proteins to manipulate host immunity and promote pathogen colonization. In a previous study, we functionally characterized a glycine-serine-rich effector PstGSRE1 with a glycine-serine-rich motif (m9). However, the mechanisms of glycine-serine-rich effectors (GSREs) remain obscure. Here we report a new glycine-serine-rich effector, PstGSRE4, which has no m9-like motif but inhibits the enzyme activity of wheat copper zinc superoxide dismutase TaCZSOD2, which acts as a positive regulator of wheat resistance to Pst. By inhibiting the enzyme activity of TaCZSOD2, PstGSRE4 reduces H2O2 accumulation and HR areas to facilitate Pst infection. These findings provide new insights into the molecular mechanisms of GSREs of rust fungi in regulating plant immunity.
Las «mártires» del fascismo español. El culto a las caídas en la Sección Femenina de Falange (1936-1942)
Authors: Barrera Begoña
Published: July 2022

El presente trabajo analiza los aspectos más relevantes del culto que la Sección Femenina de Falange dispensó a sus caídas durante la guerra y la inmediata posguerra. Su objetivo es doble: por un lado, mostrar el proceso que condujo a la Sección Femenina a crear un martirologio propio que pudiera ejercer una función cohesionadora y ejemplificante sobre las mujeres falangistas; por otro, examinar la importancia que ello tuvo para una Sección Femenina que, durante la guerra, se encontraba en plena transformación desde un grupo reducido de mujeres hasta una organización de masas. Para ello, el artículo emplea fuentes de diversa procedencia, con especial atención a los expedientes de las caídas que, desde 1939, la Sección Femenina compiló y estudió para justificar la distinción, a título póstumo, de las que consideró como heroínas del nacionalsindicalismo. El artículo consta de tres partes: en la primera, se revisan brevemente algunas aportaciones que la historiografía reciente ha realizado sobre la relación entre el culto a los caídos y el fascismo, y se defiende la necesidad de incorporar a estos enfoques una perspectiva de género atenta al papel de las mujeres en este fenómeno; la segunda parte analiza la documentación referida, con la intención de profundizar en la red de significados que se tejió en torno a nociones como las de sacrificio, abnegación o lealtad. En ella, se presta atención tanto al discurso elaborado por la Sección Femenina sobre sus caídas, como a la experiencia de las falangistas auto-consideradas mártires; la tercera parte explica el tratamiento que la organización dio a las caídas y a toda su parafernalia simbólica, en los actos celebrados durante los años de posguerra. En las conclusiones se sostiene que, aunque las falangistas no fueron combatientes directas de la guerra, la primera cultura del falangismo femenino quedó completamente condicionada por la vivencia del conflicto.
VIVES RIERA, Antoni y TORRES DELGADO, Gemma (eds.), El placer de la diferencia. Turismo, género y nación en la Historia de España. Granada, Comares, 2021, 199 pp.
Authors: Larrinaga Rodríguez Carlos
Published: July 2022

Reseña del libro: VIVES RIERA, Antoni y TORRES DELGADO, Gemma (eds.), El placer de la diferencia. Turismo, género y nación en la Historia de España. Granada, Comares, 2021, 199 pp.
RUIZ RODRÍGUEZ, Juan Ángel, Estampas extremeñas. Vida y tiempo de Anselmo Trejo Gallardo (1904-1940). Badajoz, Diputación de Badajoz, 2021, 523 pp.
Authors: Sánchez Recio Glicerio
Published: July 2022

Reseña del libro: RUIZ RODRÍGUEZ, Juan Ángel, Estampas extremeñas. Vida y tiempo de Anselmo Trejo Gallardo (1904-1940). Badajoz, Diputación de Badajoz, 2021, 523 pp.
Affectivité et phantasia dans le jeu théâtral
Authors: Finetti Stéphane
Published: July 2022

This paper investigates the relationship between affectivity and phantasy in the theatrical experience from a phenomenological perspective. It is divided in two parts. The first part deals with Eugen Fink’s Fundamental phenomena of human existence, which describes the theatrical experience as intertwining of affectivity and phantasy: on one hand, it consists in the phantasy-consciousness of the world of play (Weltspiel); on other hand, it implies an affective openness to the world of play. The second part is devoted to Marc Richir’s phenomenology, which allows investigating deeper the intertwining between affectivity and phantasy in the theatrical experience. First of all, it shows that the phantasy- consciousness involved in the theatrical experience is a “perceptive” phantasy. It also allows rethinking the affective dimension of the theatrical experience as sentiment of sublime. The paper ends with a comparison between the phenomenological perspectives of Fink and Richir, focused on the concept of μίμησις and on the metaphor of earth shaking (Erschutterung).
Die Musikalität der Phantasie
Authors: Ip Leonard
Published: July 2022

The article presents analyses of the manner in which “phantasy”, Marc Richir’s preferred concept of the imagination, can be observed and understood with clarity in relation to the experience of music. By elaborating examples of musical experience, to which Richir refers in his analyses of phantasy, it is shown that phantasy expresses itself as the originally affective dimension of experience, articulated by the correlation between the lived-bodiliness of phantasy (Phantasieleiblichkeit) and the sublime affectivity of the phenomenological apeiron. To this end, the systematic connection between music and phantasy, the concept of rhythm, the unique mobility of Phantasieleiblichkeit, and the sublime dimension of affectivity will be successively explored.
L’excroissance des bords: désalignement transcendantal et phantasia
Authors: Posada Pablo
Published: July 2022

This article seeks to enlighten the deep connection between three concepts: 1. The phantasia-affection, 2. What Marc Richir called, in his first book (1977) “the beyond of the Copernican reversal” and, finally, 3. Architectonics in its phenomenological effectiveness. Firstly, we introduce the concept of “transcendental misalignment”, thereby underlining the intrinsically hyperbolic structure of acts of representation. Mereology will then allow us to trace the difference between phantasia-affection (as a concrete whole) and the imagination-affect complex (as a fragmentable whole). Finally, it is the force of mereological concrescence that relates affection to its (mereological) exposure to a plurality of worlds. It is with the help of Rainer Maria Rilke and Antonio Machado, that we will illustrate architectonics as the multistratification of experience itself. The subject experiences indeed the irreducibility of registers, i.e., their fundamental non-concrescence.
De l’affectivité sauvage aux passions artificielles : Maine de Biran et la critique phénoménologique de l’idéologie
Authors: Arce González David Andrés
Published: July 2022

The goal of this essay is to suggest some elements for a phenomenological critique of ideology, based on the philosophy of affectivity proposed by Maine de Biran at the beginning of the XIX century. It also draws on the work of the Belgian phenomenologist Marc Richir, who developed some of the concepts postulated by Maine de Biran into a theory of intersubjective affectivity centered on the concept of contagion. The last part is an attempt to use these concepts for a critical analysis of the influence advertisements have on our affective disposition and how said influence modifies our phenomenological comprehension of the world.
Dylematy transhumanizmu I: ewolucja biologiczno-technokulturowa a ulepszanie człowieka
Authors: Grabińska Teresa
Published: July 2022

W artykule przedstawia się ewolucję: biologiczną, społeczną i technologiczno-kulturową oraz biologiczno-technologiczną i czysto kulturową. Dwóm ostatnim towarzyszy ideologia transhumanizmu, a ich podstawą są nowe zintegrowane technologie stosowane w czwartej rewolucji przemysłowej i planowanej piątej. Transhumanizm zdaje się zastępować tradycyjne nauki humanistyczne. Ma na celu afi rmację technicyzacji struktur nieorganicznych i biologicznych, w tym człowieka najpierw bionizowanego, następnie cyborgizowanego, aż do jego wirtualizacji. Technicyzacji ma podlegać otoczenie przyrodnicze i społeczne. Wskazuje się na powstające problemy ontyczne i etyczne w obliczu symbiozy bytów naturalnych i technicznych.
Dylematy transhumanizmu II: wartości transhumanistyczne a optymalizacja technologiczna
Authors: Grabińska Teresa
Published: July 2022

Przedmiotem rozważań są wartości transhumanistyczne sformułowane przez Nicka Bostroma, których realizacja ma uzasadniać dynamiczny proces technicyzacji środowiska życia człowieka i jego biologicznej konstytucji. Powrót do nienowej propozycji Bostroma i jej kolejna krytyczna analiza pozwalają poznać głębiej cele ideologii transhumanizmu, która zaczyna zastępować tradycyjną humanistykę. Wynik analizy wskazuje na konieczność powrotu do tradycyjnego systemu wartości etycznych i zachowania w ewoluującym transczłowieku osoby ludzkiej. W artykule przybliża się także stan i możliwości nowych zintegrowanych technologii GRIN, których wprowadzanie, w dużej mierze sterowane prawami komercji, zagraża utratą kontroli człowieka nad jego własnym wytworem.
Semiautomated Algorithm for the Diagnosis of Multiple System Atrophy With Predominant Parkinsonism
Authors: Lee Woong-Woo , Kim Han-Joon , Lee Hong Ji , Kim Han Byul , Park Kwang Suk , Sohn Chul-Ho , Jeon Beomseok
Published: July 2022

Objective Putaminal iron deposition is an important feature that helps differentiate multiple system atrophy with predominant parkinsonism (MSA-p) from Parkinson’s disease (PD). Most previous studies used visual inspection or quantitative methods with manual manipulation to perform this differentiation. We investigated the value of a new semiautomated diagnostic algorithm using 3T-MR susceptibility-weighted imaging for MSA-p.Methods This study included 26 MSA-p, 68 PD, and 41 normal control (NC) subjects. The algorithm was developed in 2 steps: 1) determine the image containing the remarkable putaminal margin and 2) calculate the phase-shift values, which reflect the iron concentration. The next step was to identify the best differentiating conditions among several combinations. The highest phaseshift value of each subject was used to assess the most effective diagnostic set.Results The raw phase-shift values were present along the lateral margin of the putamen in each group. It demonstrates an anterior- to-posterior gradient that was identified most frequently in MSA-p. The average of anterior 5 phase shift values were used for normalization. The highest area under the receiver operating characteristic curve (0.874, 80.8% sensitivity, and 86.7% specificity) of MSA-p versus PD was obtained under the combination of 3 or 4 vertical pixels and one dominant side when the normalization methods were applied. In the subanalysis for the MSA-p patients with a longer disease duration, the performance of the algorithm improved.Conclusion This algorithm detected the putaminal lateral margin well, provided insight into the iron distribution of the putaminal rim of MSA-p, and demonstrated good performance in differentiating MSA-p from PD.
Sensitivity of Detecting Alpha-Synuclein Accumulation in the Gastrointestinal Tract and Tissue Volume Examined
Authors: Shin Chaewon , Kim Seong-Ik , Park Sung-Hye , Shin Jung Hwan , Lee Chan Young , Yang Han-Kwang , Lee Hyuk-Joon , Kong Seong-Ho , Suh Yun-Suhk , Kim Han-Joon , Jeon Beomseok
Published: July 2022

Objective This study aimed to evaluate whether a larger tissue volume increases the sensitivity of detecting alpha-synuclein (AS) pathology in the gastrointestinal (GI) tract.Methods Nine patients with Parkinson’s disease (PD) or idiopathic rapid eye movement sleep disorder (iRBD) who underwent GI operation and had full-depth intestinal blocks were included. All patients were selected from our previous study population. A total of 10 slides (5 serial sections from the proximal and distal blocks) per patient were analyzed.Results In previous studies, pathologic evaluation revealed phosphorylated AS (+) in 5/9 patients (55.6%) and in 1/5 controls (20.0%); in this extensive examination, this increased to 8/9 patients (88.9%) but remained the same in controls (20.0%). The severity and distribution of positive findings were similar between patients with iRBD and PD.Conclusion Examining a large tissue volume increased the sensitivity of detecting AS accumulation in the GI tract.
Cardiac ion channel expression in the equine model ‐ In‐silico prediction utilising RNA sequencing data from mixed tissue samples
Authors: Premont Antoine , Saadeh Khalil , Edling Charlotte , Lewis Rebecca , Marr Celia M. , Jeevaratnam Kamalan
Published: July 2022

Understanding cardiomyocyte ion channel expression is crucial to understanding normal cardiac electrophysiology and underlying mechanisms of cardiac pathologies particularly arrhythmias. Hitherto, equine cardiac ion channel expression has rarely been investigated. Therefore, we aim to predict equine cardiac ion channel gene expression. Raw RNAseq data from normal horses from 9 datasets was retrieved from ArrayExpress and European Nucleotide Archive and reanalysed. The normalised (FPKM) read counts for a gene in a mix of tissue were hypothesised to be the average of the expected expression in each tissue weighted by the proportion of the tissue in the mix. The cardiac‐specific expression was predicted by estimating the mean expression in each other tissues. To evaluate the performance of the model, predicted gene expression values were compared to the human cardiac gene expression. Cardiac‐specific expression could be predicted for 91 ion channels including most expressed Na+ channels, K+ channels and Ca2+‐handling proteins. These revealed interesting differences from what would be expected based on human studies. These differences included predominance of NaV1.4 rather than NaV1.5 channel, and RYR1, SERCA1 and CASQ1 rather than RYR2, SERCA2, CASQ2 Ca2+‐handling proteins. Differences in channel expression not only implicate potentially different regulatory mechanisms but also pathological mechanisms of arrhythmogenesis.
التبادل والتكامل بين الثقافتين الصينية والعربية الوسطي والتوفيقية من منظور / Inter-communication and Mutual Reference Between Chinese and Arab Civilizations: Based on the Perspective of the Golden Mean and Conciliation
Authors: Minyan Wu
Published: July 2022

The two ideas of moderation and syncretism are among the most distinctive ideas about the Chinese and Arab cultures, as they are similar in many aspects, such as the historical ground of their formation and development, the problems they are trying to address and the questions they raise, and moral, spirit and values that can be read through them. Comparing these two ideas contributes to a deep understanding of the values and ideas they share, as this comparison provides a solid basis for achieving exchange and integration between them. This kind of communication and exchange is particularly urgent in the context of realizing the “Belt and Road” slogan and the slogan of “A common future for mankind.” At the same time, it is necessary to recognize the differences between the two cultures when making the comparison, so the path leading to the integration of the Chinese and Arab cultures must be through adherence to the ideas of mutual understanding and openness advocated by both moderation and syncreticism, with awareness of their own identity.
التبادل الصيني العربي والثقافة العربية في الصين في عهد أسرتي مينغ وتشينغ / The Friendly Exchanges Between China and Arab Countries During Ming and Qing Dynasties
Authors: Yueyang Chen
Published: July 2022

The friendly exchanges between China and Arab countries have a long history. During Ming and Qing Dynasties, the cultural exchange between China and Arab countries was gradually shifted from the material level in Tang and Song Dynasties to the spiritual level. During that period, with the increase in the number of Muslims in China, and the deepening of Chinese people’s interest to the Arab world, research on the history and geography of Arab countries was strengthened, and traditional Chinese Confucian ideology was combined with the ideology of Arab Islamic culture, which promoted the integration and dialogue between Chinese Muslims and people who believed in Confucianism, and made Arab Islamic culture and Chinese culture have a deeper integration.
The effect of cutoff angle on the head pressure underneath dams constructed on soils having rectangular void
Authors: Musa Taghreed Abd-Almahdee , Shlash Marwah Abdullah , Mohammed Hayder Sami
Published: July 2022

In this research, a hydraulic model is used to find the effect of the cutoff angle and dimensions of the void in the soil on the head pressure and leakage under the dam, and finding the best angle and size of the void will have a positive effect. The model was designed with a cutoff that can be moved in three angles (45°, 90° and 135°) in the center of the dam and three ratios of void dimensions (width of the void (W)/the dam width (b) = 0, 0.34 and 0.69) were taken. Head pressure was measured using a piezometer installed in the front of the model. When the flow reached the balance, leakage and pressure head were measured. From the results, it was observed that the lowest head pressure value occurs when the angle is 90° and the void ratio is 0.69. The principles of dimensional analysis and non-linear regression by using IBM SPSS 19 were used to find an empirical formula for the computation of the head pressure depending on the angle of the cutoff and the size of the void.
Heterogeneous capital tax competition in a federation with asymmetric tax compliance
Authors: Grazzini Lisa , Petretto Alessandro
Published: July 2022

In a federal country with two regions, consumers can decide not only the region where to invest, but also the type of capital investment. We analyse how such decision is affected by the fact that a first type of capital is taxed at a regional level while a second one is taxed at a federal level with tax compliance for federal taxation varying across regions. A standard horizontal tax competition arises for the first type of capital across regions. Instead, vertical tax competition arising between the regional and the federal level is not standard because there is not tax base overlap between the two tiers of government. However, both regional and federal tax bases are affected by tax policies decided by each level of government via capital movements from one type of capital towards the other one. Our main result shows under which conditions an increase in federal taxation in response to an increase in tax noncompliance may be less severe than in a set-up with only one type of capital because of capital flights arising not only across regions, but also across different types of capital investment.
The Testing Methods and Prediction Models for Concrete Corrosion in Sewer Pipelines: A State-of-the-Art Review
Authors: Wang Yajian , Li Pengpeng , Wang Linbing
Published: July 2022

Microbiologically induced concrete corrosion (MICC) is a specific occurrence in sewer systems where the cementitious materials are eroded toward a paste by microbiological processes. MICC has been one of the factors causing huge asset losses and urban hazards worldwide. Addressing this issue, some tests investigating the long-term performance of sewer pipes have been carried out, and a good number of testing data has been accumulated since the end of the 19th century. In this paper, these experimental works and results are collected in the expectation that they serve as a basis for service life prediction. Therefore, long-term performance test methods for sewage pipes including sulfuric acid (H2SO4) acid immersion, microbial feeding chambers, demonstration plants, in situ tests, artificially enhanced effluent erosion, and artificial pipe wall thinning are comprehensively reviewed. Meanwhile, the applicability of each method is discussed regarding its merits. Furthermore, the proposed data-driven corrosion models are outlined, and it is found that the input data for these models are primarily testing results because of the incomplete and lack of historical operational data sets. Future efforts aimed at the remaining life prediction for sewer pipelines are also suggested. The present work will serve as a guide and offer new insights for those who are preparing to investigate the long-term performance of sewer pipes.
Agent Data Encryption and Storage Algorithm for Wireless Sensor Networks Based on Blockchain Technology for Future Smart City Networks
Authors: Peng Jianxi , Li Jianhui
Published: July 2022

Aiming at the problems of long storage time and low encryption accuracy of the traditional agent data encryption storage algorithm in wireless sensor networks, an agent data encryption storage algorithm based on blockchain technology is proposed. Analyze the blockchain hierarchy and data, take the sensor node with the signal energy value exceeding the predetermined threshold as the source node for generating sensing data, and obtain the agent data transmission path of the wireless sensor network. Based on the obtained agent data transmission path in the data layer of data block, the agent data are encrypted by generating an encryption key and data encryption. According to the agent data encryption results, the agent data encryption storage model of the wireless sensor network is constructed. The simulation results show that the proposed algorithm has shorter storage time and higher encryption accuracy.
Susceptibilities of Yersinia pestis to Twelve Antimicrobial Agents in China
Authors: He Jian , Yang Xiaoyan , Jin Juan , Xin Youquan , Wang Yiting , Li Sheng , Zhang Qi , Wang Yumeng , Wu Hailian , Bai Jixiang , Xiong Haomin , Jin Yong , Li Juan , Zhang Xuefei , Dai Ruixia , Li Wei
Published: July 2022

Objective:

Streptomycin is the preferred choice for therapy of plague in China and other countries. However, Yersinia pestis exhibiting plasmid-mediated antimicrobial agent–resistant traits had been reported in Madagascar. In this study, we evaluated the susceptibility of traditional or newer antimicrobial agents used for treatment and/or prophylaxis of plague.

Methods:

Following Clinical and Laboratory Standards Institute (CLSI) recommendations, the susceptibility of 12 antimicrobial agents was evaluated by the agar microdilution method in 1,012 strains of Y. pestis isolated from 1943 to 2017 in 12 natural plague foci in China.

Results:

One clinical Y. pestis isolate (S19960127) was found to be highly resistant to streptomycin, while the strain was still sensitive to other 11 antibiotics, that is, ciprofloxacin, ofloxacin, kanamycin, chloramphenicol, ampicillin, ceftriaxone, cefuroxime, trimethoprim-sulfamethoxazole, tetracycline, spectinomycin and moxifloxacin. The remaining 1,011 Y. pestis strains in this study demonstrated susceptibility to the above-mentioned 12 antimicrobial agents.

Conclusion:

Antimicrobial sensitivity surveillance of Y. pestis isolates, including dynamic monitoring of streptomycin resistance during various clinical plague treatments, should be carried out routinely.
Trayectorias educativas y expectativas de futuro de las juventudes. Un estudio de caso en escuelas secundarias de La Pampa, Argentina
Authors: Hormaeche Lisandro David , Bueno Mayra Betsabé
Published: July 2022

The objective of this study was to analyze the future expectations of young people with different school backgrounds who attended the last year of secondary education in two schools in the city of General Pico, La Pampa, Argentina. For this, an exploratory qualitative methodological design was chosen based on a case study from the selection of two secondary schools in the city. Focus-group interviews and a series of surveys were applied. The results show a diversity of trajectories and decisions that young people will make. The general conclusions of the work show that the future expectations of young people are closely related to their trajectories throughout secondary education.
Estudio sobre motivación en estudiantes de la Universidad Tecnológica El Retoño
Authors: Coronado Guzman Graciela , Gómez Ortiz María Gabriela , Molina Díaz José Guadalupe , Popoca Zamarripa Jessica Lucero , López Reyes César
Published: July 2022

The motivation to learn is a constant concern of university professors who focus on the challenge of promoting interest in genuine learning. In the investigation, the MAPE-3 questionnaire was applied to a sample of 751 students of higher technical level (TSU) and degree from the Technological University El Retoño (Mexico) to know the levels of intrinsic and extrinsic motivation, as well as the difference between them. according to the level studied. The results show an interest in learning itself, expressed in a greater intrinsic motivation (72.09) than extrinsic (40.5). Similarly, it is observed that intrinsic motivation maintains the same mean in both grades, while extrinsic motivation is not similar.
Gestión de espacios públicos para la animación a la lectura en jóvenes en un barrio del distrito de Ate Vitarte, Perú
Authors: Carbajal Quiñonez Juan Carlos
Published: July 2022

In the present study, the current discussion regarding the issue of public spaces is addressed and the guidelines and approaches that exist for the construction of the concept around its use for the encouragement of reading are exposed. Our objective was to carry out a workshop linked to literary reading and other cultural aspects such as music, drawing and painting; It was aimed at adolescents and young people from a secondary school in the city of Lima. The methodology used was exploratory, through a project structure file, presenting workshops to encourage literary reading specifically from the Ate Vitarte district and the Valdiviezo neighborhood, in Lima, Peru. After the investigation was concluded, it was observed that the young participants in the workshops, by writing their stories, their poems or those who enjoyed participating as spectators in the meetings, were able to recognize and revalue their intellectual abilities. In conclusion, through these meetings a possibility was created for new public spaces in relation to the encouragement of reading.
Dimensiones de liderazgo pedagógico-docente en entornos universitarios: liminares de innovación educativa
Authors: Ramírez-Hernández Adoniram
Published: July 2022

The present work offers a vision of pedagogical-teaching leadership as a framework that formulates capacities and commitments of the teacher in educational acts oriented towards school improvement, teaching practice, collaborative work and academic management in a diversity of university socio-cultural environments. It is proposed to reflect on education and its object of knowledge and practice, where the educational action located in an epistemological perspective recovers a framework of direct relationship between the knowledge of education and the function of educating; question linked to the pedagogy of profuse mesoaxiological gear as a discipline and career. For this, the documentary hermeneutical paradigm was used. The review allowed to have a dimensional proposal for educational innovation, where a leader promotes the individual and collective construction of the field and his disciplinary path. These results allow us to infer that this teacher training provides an educational framework that highlights a liminal vision of a mesoaxiological nature in the pedagogical subject. Under this scrutiny, we converge in pointing out the associative value in the investigative and functional areas, which crystallize with pedagogical strength the technical-operative capacity of educational agents for innovation.