bluuebunny/crossref_metadata_2025 huggingface dataset:
Data Science in Public Relations Software Development
Authors:   Senior Software Developer at CisionMorrisville, N C, USA, Madupati Bhanuprakash
Published: September 2024

The integration of data science into public relations (PR) software development has revolutionized the field by providing PR professionals with advanced tools for analyzing, managing, and leveraging data to craft effective communication strategies. This paper investigates how data science enhances PR software tools, emphasizing areas such as advanced analytics, sentiment analysis, media monitoring, and campaign optimization. By employing sophisticated techniques from machine learning, natural language processing, and big data analytics, PR software now offers enhanced capabilities for understanding public sentiment, monitoring media coverage, and optimizing campaign performance. The paper outlines the benefits of these technological advancements, discusses the challenges and limitations faced during implementation, and explores future directions for the continued integration of data science in PR software development. The study underscores the transformative impact of data science on PR practices and highlights ongoing trends and potential future developments.
Enhancing OmniStudio Components Deployment for Salesforce ISV Partners
Authors:   USA, Haridasan Praveen Kotholliparambil
Published: September 2024

OmniStudio is changing how Independent Software Vendors (ISVs) develop and share experiences and user interfaces across various Salesforce industry cloud solutions following Salesforce’s acquisition of Vlocity. This article offers an in-depth look at OmniStudio's features and key elements, as well as a workaround for ISVs to easily distribute these elements until Salesforce makes them packable. The article also discusses the obstacles ISVs face when using OmniStudio and the creative workaround solutions to overcome these obstacles.
Streamlining Payment Process in Cloud Enterprise Resource Planning Application
Authors:   USA, Prasad Thejas
Published: September 2024

In the current landscape of the organization, multiple disparate payables applications are used to manage and execute payments directly to banks, leading to significant challenges in tracking, organizing, accounting, and reporting on payables invoices and payment transactions. This fragmented approach results in inefficiencies and inaccuracies, hindering effective financial management and decision-making. To address these issues, the organization aims to streamline its payment process by centralizing all payables invoices from various systems into the Oracle Cloud Enterprise Resource Planning (ERP) application via an integrated Platform as a Service (iPaaS) middleware. By consolidating the payment process within the Oracle Cloud Payment system, the organization expects to achieve significant improvements in operational efficiency. This centralized approach will provide a single source of truth for all payment-related data, facilitating better tracking and control of financial transactions. The streamlined process will enhance the organization’s ability to generate accurate and timely financial reports, ensure compliance with regulatory requirements, and improve overall financial governance. Additionally, the Oracle Cloud ERP’s robust reporting and analytics capabilities will enable better decision-making by providing comprehensive insights into the organization’s financial health. This strategic initiative will enable the organization to improve financial reporting, enhance compliance, and reduce the risks associated with managing multiple payment channels. This also eliminates the inefficiencies associated with multiple payment systems, reducing operational risks, and establishing a scalable, future-proof financial infrastructure that can support the organization’s growth and evolving business needs.
Real-time Anomaly Detection in Financial Trading Systems: An Adaptive Approach to Mitigating Trading Errors
Authors:   USA, Majumdar Ananth
Published: September 2024

This paper presents an advanced real-time anomaly detection system designed to identify and mitigate trading errors in financial markets. Our system leverages statistical analysis, dynamic thresholds, and periodic batch processing to enhance accuracy and reduce false positives. By comparing new orders against historical data and instrument-specific thresholds, we have successfully caught erroneous trades worth millions, potentially saving significant losses for trading firms. The system utilizes Spring Batch for efficient processing and incorporates adaptive mechanisms to handle various security types and rare order scenarios. This paper details our methodology, implementation, and results, providing insights into effective risk management in high-stakes financial trading environments.
The Impact of Wind Movement on Providing Thermal Comfort in Urban Design
Authors: Musa Hala Hussein , Asadi Fawzia , Majeed Anas Hameed
Published: September 2024

The wind movement is a crucial factor in enhancing thermal comfort, forming an essential part towards friendly and sustainable urban environment. Air movement, as a prominent climatic factor, reduces heat stress with improving ventilation quality. Effective natural ventilation and heat stress mitigation can be achieved by orientation, planning and shaping the urban blocks in urban environments. Air movement represents the most important element in improving environmental adaptation, as the rapid airflow reaching buildings can significantly reduce their temperature. Site planning requires precise knowledge of the main wind directions and speeds. The research utilized the ENVI-met Models program for modeling urban environments and predicting thermal effects in the built environment. This program plays a crucial role in understanding and analyzing environmental conditions and their impact on thermal comfort. The research addressed the knowledge gap and lack of local studies in highlighting the role of wind movement in enhancing thermal comfort in urban environments using ENVI-met Models. The research aimed to provide specific knowledge in measuring wind movement and its role in enhancing thermal comfort in urban environments using the program. The research hypothesized that analyzing and modeling wind movement with ENVI-met Models can effectively contribute to understanding and improving thermal comfort in urban environments. One of the key findings is that studying the impact of wind movement with this program is essential for providing scientific and technical foundations to improve urban design and enhance thermal comfort in urban areas, promoting sustainability and environmental quality in cities
The Prevalence of Depressive Symptoms among Adults Living in the UAE during the COVID-19 Pandemic
Authors: Ghalyoun L , Abualhab M , Naji M , Mohammed A , Alsumaiti F , Alshehhi H , Karim A
Published: September 2024

Purpose: To investigate the prevalence of depressive symptoms among adults living in the UAE during the COVID-19 pandemic.
Methods: This cross-sectional study used a self-administered anonymous online questionnaire distributed in both Arabic and English via social media platforms. A total of 261 adults living in the UAE were included in the study, using a non-probability volunteer sampling. Univariate and bivariate analyses of the acquired data were analyzed using SPPS Statistics version 26. Patients clinically diagnosed with depression were excluded from this study.
Findings: Overall, the prevalence of depression among our studied population was 63%. Several parameters were correlated with depression to assess their associations. A lower household income was found to be linked to a greater likelihood of developing depression, as 74.6% of depressed subjects had an income lower than 20,000 Dhs (p=0.003). Age also had a significant correlation  (95% CI, p=0.003) with depression, and those in the younger age group (18-25 years) had a greater prevalence of depression than did those in the older age group. Difficulty performing daily activities, restless sleep, feeling lonely, feeling sad, feeling inadequate, and losing hope were the most commonly reported symptoms in depressed subjects. A total of 78.21% of our participants did not know about hotlines when they were depressed; however, this difference was not statistically significant (95% CI, p=0.178).
Unique Contribution to Theory, Practice and Policy: Depression was prevalent in 63% of our participants. A lower household income and younger age were associated with a greater risk of depression. We believe that our findings will encourage institutions and government authorities to implement awareness programs about depression awareness and screening for depression. Families should support individuals seeking professional help, particularly if their depressive symptoms are severe or persistent.
Applying Systems Theory to Ethical AI Development: Mitigating Unintended Consequences through Feedback Loop Analysis
Authors: Christian C. Madubuko, PhD., MA; PGDE, BA; Dip  , Chamunorwa Chitsungo, MBA, MSc; Grad. Cert. Dip
Published: September 2024

Purpose: The rapid adoption of Artificial Intelligence (AI) technologies has sparked critical discourse on their ethical implications. Current debates often lack a systems-oriented perspective, limiting our understanding of how AI systems can unintentionally create complex feedback loops leading to significant, unintended consequences. This paper aims to develop an integrative framework that combines Systems Theory with ethical paradigms for AI development, addressing the multifaceted challenges presented by AI technologies in society.
Materials and Methods: This research employs a systems-oriented analytical framework to elucidate how AI systems interact with various societal and environmental variables. By identifying latent feedback loops, this study reveals ethical dilemmas, including bias amplification, social inequality, and ecological degradation. The analysis critically explores how these systemic interactions impact algorithmic decision-making processes, influencing the mitigation or exacerbation of existing inequities.
Findings: The findings highlight the significant influence of systemic interactions on the ethical implications of AI deployment. By applying a systems-oriented lens, we can better address ethical challenges and enhance the efficacy and fairness of AI applications.
Implications to Theory, Practice and Policy: This paper asserts that integrating systemic thinking into the design, deployment, and governance of AI can improve ethical scrutiny and accountability. The theoretical contributions advocate for a paradigm shifts in integrating ethical considerations into AI development. The paper concludes by proposing actionable strategies grounded in Systems Theory to equip developers, policymakers, and stakeholders with tools for creating ethically robust and socially responsible AI frameworks. By engaging with ethical AI discourse through an interdisciplinary lens, this research underscores the need to align technological innovation with ethical imperatives and advocates for a transformative approach to AI development that prioritizes societal welfare.
Systematic Literature Review on Adaptation of Infographic and Acceptance Factors in Summarizing Medical And Health Literature in Higher Education
Authors: Ahmad Ahmad Khairul Azizi , Aziz Mohd Nasiruddin Abdul , Ramlie Mohd Khairulnizam , Rahaman Ashraf Abdul , Abdullah Muhammad
Published: September 2024

Infographics are visual representations of information in such a way that information can be easily understood at a glance. Infographics are a form of the most powerful stimulator of visual communication in the digital era, and it is gaining popularity among educators. The creation of teaching and learning materials has become critical for students at all levels of education. However there are still insufficient studies that have systematically reviewed the existing literature on infographic acceptance in higher education. Therefore, this article is intended to conduct a systematic literature review on infographic acceptance in facilitating teaching and learning among students in higher education. The current study has combined multiple research designs, and the review was based on the ROSES publication standard (RepOrting standards for Systematic Evidence Syntheses). This study selected papers using two of the most prominent databases: Scopus and Science Direct, and it used Google Scholar as the secondary database. A thematic analysis was implemented and 4 main themes were produced, namely 1) Presentable and efficient; 2) understandable, 3) Visual literacy, and 4) Facilitating teaching and learning. The study made several significant contributions to the body of knowledge and for practical purposes. The findings have explained the importance of visual communication specifically infographics as a tool for facilitating teaching and learning process and for providing information on specific research areas and content that should be the focus of future studies.
Calbayog City: Filipino Leader’s Business Wisdom and Management Insights for Guiding Aspiring Gen Z and Millennial Professional
Authors: Briones Fritz Jeffry Z.
Published: September 2024

This qualitative research explores the business wisdom and management insights of seasoned leaders in Calbayog City to guide aspiring Gen Z and Millennial professionals. The study addresses the evolving expectations and behaviors of these younger professionals, who prioritize flexibility, meaningful work, and work-life balance, necessitating changes in traditional management approaches. By interviewing established business leaders, the research identifies key themes including the integration of personal and corporate values, overcoming leadership challenges, nurturing talent and innovation, community engagement, and sustainable practices. The findings reveal that leaders in Calbayog City emphasize integrity, empathy, and transparent communication in their leadership styles. They implement strategies such as continuous monitoring, stakeholder involvement, and structured reinforcement programs to foster a values-driven culture. Additionally, these leaders engage in community development projects, support educational initiatives, and adopt eco-friendly practices to enhance operational efficiency and market positioning. The study concludes that the insights from these leaders can significantly enhance the leadership capabilities and management strategies of the next generation, ensuring sustained business growth, community involvement, and environmental responsibility.
Analyzing the Influence of Excessive Digital Technologies Usage towards Emotional Intelligence Development of Undergraduate IPTA Students in Klang Valley, Selangor
Authors: Amin Samir Muhazzab , Nizam Khairunnisa Mohd , Nazuri Nur Shuhamin , Suhaimi Siti Shazwani Ahmad
Published: September 2024

The relationship between social media usage, online gaming usage, online shopping usage, social skills and emotional self-regulation has been studied in many Western countries. Nevertheless, the relationship between these variables has not been extensively studied. The objective of this study is to determine the influence of social media usage, online gaming usage, online shopping usage on undergraduate students’ social skills and emotional self-regulation. A total of 400 undergraduate students from eight universities in Malaysia participated in this study. In terms of social media usage, the levels are high, while online gaming and online shopping usage are moderate. On the other hand, respondents exhibit very low emotional self-regulation, whereas their social skills are notably high. There are differences between males and females in terms of social skills and emotional self-regulation. Females exhibit higher levels of social skills, while males show higher levels of emotional self-regulation. Through the survey, the study confirmed that all variables have a significant relationship towards social skills and emotional self-regulation. The study also found that social media usage has the most significant positive impact on social skills. Meanwhile, the relationship between social media usage has negatively significant towards emotional self-regulation. It can be concluded that the relationships between social media usage, online gaming usage, online shopping usage, social skills, and emotional self-regulation among undergraduate students in Malaysia have significant implications.
Sustainable Production Strategies: Incorporating Internet Celebrity Aspects into Yingjing Black Sand Craft Design
Authors: Xuemin You , Legino Rafeah , Xiao Pan , Fuad Md Arif Mohd , Ling Wang
Published: September 2024

The study aims to explore the intersection of traditional Yingjing black sand products with modern digital age adaptations, focusing on sustainability, cultural symbolism, and the evolving consumer landscape influenced by network platforms. The research employs a tripartite design framework. The first phase involves analysing ‘Internet Celebrity’ characteristics and their associated poetic imagery to understand their impact on consumer behaviour. In the second phase, the study extracts shape semantics from these elements, translating them into actionable design information. The final phase introduces a four-step design process, utilising 3D modelling to create a Yingjing black sand product inspired by ‘Internet Celebrity’ elements. This phase highlights the integration of digital tools in refining traditional craft designs. The research demonstrates that adapting traditional Yingjing black sand crafts to modern consumer trends through digital tools and sustainable production strategies can enhance their relevance in the digital age. The study underscores the importance of preserving historical significance while promoting environmentally conscious design and production. This research provides innovative insights into the adaptation of traditional crafts within the context of the digital age. It offers a structured approach to integrating modern consumer trends with historical craftsmanship, presenting a compelling model for sustainable craft production. The study contributes to broader discussions on sustainability, cultural adaptation, and the evolution of traditional crafts, making it relevant for both academic and practical applications.
Transformative Teaching Practices: The Lived Experiences of Educators in the Catch-Up Fridays Program
Authors: Pacana Rowell O. , Cabaguing Abigail M.
Published: September 2024

This phenomenological study explores the lived experiences of secondary public school teachers participating in the Catch-Up Fridays program. The initiative, designed to address learning gaps and enhance student outcomes, mandates that teachers dedicate Fridays to improving students’ literacy and numeracy. Using Husserlian transcendental phenomenology, the study captures the complexities of teachers’ engagement, highlighting both the intrinsic and extrinsic motivations behind their participation. Key themes include compliance with educational directives, the role of teachers as catalysts of change, emotional rewards and student engagement, and challenges in execution. Findings reveal that while teachers are driven by professional duty and a commitment to student improvement, they face significant obstacles such as unclear implementation guidelines, lack of prepared materials, and doubts about the program’s long-term effectiveness. Despite these challenges, teachers report a deep sense of fulfillment from witnessing student progress and engagement. The study underscores the need for better communication, resource provision, and long-term planning from educational authorities to support teachers effectively. By addressing these issues, the Catch-Up Fridays program can be enhanced to better meet its goals of improving educational outcomes for students. The research contributes valuable insights into the practical realities faced by teachers and the critical factors influencing the success of educational initiatives.
O PAPEL DO DIREITO DE ARREPENDIMENTO PARA O CONSUMIDOR E SUAS EXCEÇÕES À LUZ DO CÓDIGO DE DEFESA DO CONSUMIDOR
Authors: Garcia Ferreira Luana
Published: September 2024

Esse trabalho aborda o direito de arrependimento de compra de um produto ou serviço dentro do Código de Defesa do Consumidor, conforme versa o Decreto n° 7.962/13 que regulamenta tal obrigação dos fornecedores aos consumidores. Essa norma geral limita que dentro de um prazo de 07 (sete) dias, o consumidor exerça seu direito de arrependimento, o que o possibilita ter o reembolso integral do valor pago e devidamente corrigido. Essa lei garante tal proteção perante todas as compras realizadas fora do estabelecimento comercial, ou seja, via internet, permitindo que o consumidor tenha prazo e possa captar informações suficientes para uma decisão sobre a conveniência da contratação do produto ou serviço, pois no caso das lojas físicas, o direito de arrependimento fica condicionado à livre e espontânea vontade do lojista. Dentro dessa legislação existem algumas exceções de produtos e serviços que não se encaixam no direito de arrependimento, dos quais alguns exemplos serão abordados posteriormente. Visto isso, o objetivo desse artigo é abordar o papel do direito do arrependimento para o consumidor, incluindo quais são as exceções de compras geralmente realizadas fora do estabelecimento comercial, fazendo com que as boas relações de consumo sejam mantidas de maneira equilibrada para ambas as partes. O método utilizado para a realização desse trabalho foi a fundamentação teórica como a parte do texto que apresenta o embasamento científico para o tema da pesquisa.
O artigo 26 da Lei de Introdução às Normas do Direito Brasileiro (LINDB) como cláusula geral de negociação administrativa: proposta de procedimentalização do exercício do consenso
Authors: Silva Clarissa Sampaio , Romão Pablo Freire
Published: September 2024

Objetiva-se analisar, a partir da evolução da consensualidade no direito administrativo, o art. 26 da Lei de Introdução às Normas do Direito Brasileiro (LINDB), que instituiu a cláusula geral de negociação administrativa. Trata-se de pesquisa exploratória e qualitativa. Como resultados, verificou-se que a via negocial é forma de atuação posta à disposição da Administração Pública capaz de concretizar o interesse público. Após a decomposição do conteúdo do art. 26 da LINDB, constatou-se a necessidade de cada ente federado estabelecer um procedimento para a celebração de acordos administrativos, tendo em vista as desconfianças, internas e externas, que pairam sobre a via negocial. Ao final, o artigo propõe um rito mínimo e básico capaz de assegurar a estabilidade e a segurança jurídica necessárias ao exercício do consenso, visando tornar possível a inserção definitiva da consensualidade na praxe administrativa, tendo em vista os preconceitos ainda enfrentados pelos gestores e seus respectivos controladores.
Uma análise da história da matemática presente em livros didáticos na perspectiva da decolonialidade
Authors: Baluz Leticia , Flores Cláudia Regina , Da Silva Neto Benjamim Cardoso
Published: September 2024

O presente trabalho tem por objetivo analisar o modo como a História da Matemática tem sido apresentada em uma coleção de livros didáticos a partir de uma perspectiva decolonial.  Para isso, escolhemos a coleção de livros Matemática Interligada, do ano 2020, da Editora Scipione, composta de seis volumes, distribuída em escolas públicas do estado do Maranhão. Em nossas discussões, observamos que a presença da História da Matemática é ponto comum e naturalizado, e é frequente que tais eventos estejam associados a matemáticos europeus e suas descobertas, criando a impressão de que todo conhecimento matemático surge a partir de um único indivíduo. No entanto, é fundamental reconhecer que o desenvolvimento da matemática ocorreu em todo o mundo de maneiras diversas, envolvendo tanto homens quanto mulheres, e não se limitou apenas ao contexto europeu.
Making and Unmaking the Carolingians
Authors: Airlie Stuart
Published: September 2024

How does power manifest itself in individuals? Why do people obey authority? And how does a family, if they are the source of such dominance, convey their superiority and maintain their command in a pre-modern world lacking speedy communications, standing armies and formalised political jurisdiction? Here, Stuart Airlie expertly uses this idea of authority as a lens through which to explore one of the most famous dynasties in medieval Europe: the Carolingians.

Ruling the Frankish realm from 751 to 888, the family of Charlemagne had to be ruthless in asserting their status and adept at creating a discourse of Carolingian legitimacy in order to sustain their supremacy. Through its nuanced analysis of authority, politics and family, Making and Unmaking the Carolingians, 751–888 outlines the system which placed the Carolingian dynasty at the centre of the Frankish world. In doing so, Airlie sheds important new light on both the rise and fall of the Carolingian empire and the nature of power in medieval Europe more generally.
The Almoravid Maghrib
Authors: Gómez-Rivas Camilo
Published: September 2024

The Almoravid Maghrib uncovers the richness and complexity of a neglected past. A pivotal moment in the history of North Africa, the rise of the Almoravids brought a corner of the Maghrib into closer contact with the world around. From the Cid to the Seljuqs, the Almoravids impressed contemporaries in ways no Maghribi regime had, signalling a transformation of western North Africa through burgeoning trans-Saharan and trans-Mediterranean commerce, urbanization (two of Morocco's four imperial cities were founded), and the epic encounter with the Christian, Muslim, and Jewish cultures of Iberia. The Almoravids witnessed a series of key transformations and beginnings, including the introduction of one of the area's most successful gold currencies, the formulation of a new religious orthodoxy, the parallel rise of counter-movements (popular, messianic, and spiritual), and the inception of pan-Maghribi-Andalusi artistic, literary, and architectural styles.
Partial Agonist, Full Barrier: A Case-Based Discussion on Challenges with Buprenorphine in Chronic Pain Management
Authors: Hershman Tonya S. , Park Michelle
Published: September 2024

Background: More patients are on chronic opioids, as patients who were initially started on full agonist opioids for cancer-related pain are living longer. Despite doing well from the cancer standpoint, some patients have difficulty tapering off their opioids because they have been taking them for years. Given the potential complications of chronic full agonist opioids, it is important to manage these patients in a safer way. However, there are various challenges including lack of education for patients and healthcare professionals and lack of product availability. Many healthcare providers do not have much formal training on initiating, maintaining, and tapering the various buprenorphine products. These providers may not be able to effectively educate patients given the lack of education. Also, patients research these products on their own and are hesitant to try them because of misinformation. Even if patients are informed thoroughly about buprenorphine, there are barriers to obtaining them including insurance denial and lack of product availability at pharmacies. Given the above challenges, easily accessible best practices as well as avenues for healthcare professionals to educate and guide each other are needed.
Purpose/hypothesis: Given the potential complications of chronic full agonist opioids, it is important to manage these patients in a safer way. However, there are various challenges including lack of education for patients and healthcare professionals and lack of product availability.
Conclusions/applications: Given the above challenges, easily accessible best practices as well as avenues for healthcare professionals to educate and guide each other are needed.
Buprenorphine: Not Just Another Opioid — Understanding the World's Most Interesting Opioid
Authors: Rubinstein Andrea
Published: September 2024

Background: In this talk we will delve deep into the pharmacology of this drug and how it’s receptor interactions are unique and then we will take that understanding and apply it to clinical usage to see how this drug behaves in a variety of situations.
Purpose/hypothesis: Specifically we will look at the safety profile of this drug, including it’s ceiling effect on respiratory depression. Then we will look at efficacy, how well does this drug work in the treatment of pain. We will look at analgesia, tolerance and anti-hyperalgesic properties of buprenorphine. We will discus why this drug is so versatile anyhow versatility is a key asset when it comes to using buprenorphine for the treatment of pain.
Conclusions/applications: The last section of this talk will look at the specific area of preoperative use of buprenorphine and why buprenorphine should be continued throughout the preoperative period.
The "Micro"cosm: Magnifying the Nuance of Low Dose Buprenorphine Inductions
Authors: Uritsky Tanya , Casey Emily
Published: September 2024

Background: Now that the X-wavier is a thing of the past, patients with Opioid Use Disorder (OUD) who previously lacked access to buprenorphine may have access to lower barrier care and may be looking to make the transition from either methadone or illicit fentanyl to buprenorphine. This can be quite challenging and both fentanyl and methadone are hihghly potent drugs and can result in a difficult transtition to buprenorphine.
Purpose/hypothesis: A transition from high potency opioids to buprenorphine is challenging and can cause discomfort or withdrawal in patients.
Procedures/data/observations: Patients tend to have a difficult time when undergoing a transition from significant fentanyl use (> 1 bundle/day) or high dose methadone to buprenorphine. Over the last year, we've supported this transition for our hospitalized patients and have learned some tips and tricks to ease the transitions. Through our work we've come up with a strategy to transition patients that includes utilizing full mu agonists while initiating a low dose buprenorphine induction. We have developed an informal protocol for this transition that takes advantage of the flexibility of low dose buprenorphine induction strategies and includes the use of non-opioid adjuvant medications to control symptoms of discomfort and withdrawal.
Conclusions/applications: A transition from the use of significant fentanyl or high dose methadone to buprenorphine is possible and can take place over a matter of a few days. Such a transition requires careful attention to patient symptoms, availability of as needed short acting opioids, and the judicious use of non-opioid adjuvants.
Buprenorphine: Opioid Agonist-Antagonist for Refractory Pain of Sickle Cell Disease Patients During Hematopoietic Stem Cell Transplant, Uncontrolled By Full-Agonist Opioids
Authors: Sakae Mayuko
Published: September 2024

Background: Bone marrow transplant (BMT) offers potential cure for cancer and a spectrum of otherwise incurable diseases. The BMT process can cause multi-systemic pain in patients with sickle cell disease (SCD) refractory to high-dose opioid analgesics during BMT because of their pre-existing opioid-tolerance.  Because of frequent pain resulting in hyperalgesia and chronic opioid use, SCD patients undergoing BMT often experience excruciating pain uncontrolled by exceedingly high-dose opioids with severe and intolerable adverse effects.
Purpose/hypothesis: There is a small but growing body of literature about the successful buprenorphine effect for SCD's chronic pain management that had failed sufficient pain relief by the traditional full-agonist opioids in the outpatient setting.  However, the buprenorphine use for acute inpatient pain management has not been previously researched. Pilot prospective clinical trial with buprenorphine-based pain management for acute BMT-related pain was initiated for SCD patients’ pain uncontrolled by full-agonist opioids.
Procedures/data/observations: Buprenorphine was started as scheduled and as-needed analgesics, supplemented by full-agonist opioids upon consultation for uncontrolled BMT-related pain of SCD patients.  Patients' 24-hour opioid requirement by morphine equivalent daily doses (MEDD) were assessed at 3 time points: 1)immediately before pain escalation; 2)consultation; 3)discharge.  MEDDs were compared to those of patients treated with full-agonist opioids only. Cases treated by full-agonist opioids (morphine/hydromorphone/fentanyl/methadone/oxycodone) had MEDD escalation by 1230-16300% by discharge compared to immediately before BMT-related pain escalation.  Buprenorphine-supported cases had significantly smaller MEDD increase by 220-317%.
Conclusions/applications: Our case series suggests superior pain control by adding Buprenorphine prior to opioid dose escalation during BMT for SCD.  Buprenorphine may provide the advantageous effect for other patients with complex pain background and experiencing difficult pain management during BMT due to pre-existing hyperalgesia and high opioid-tolerance. The evidence for buprenorphine's analgesic effect is moderate but growing, and more randomized controlled trials comparing the buprenorphine and other standard opioids are needed.
Impact of an Education Module on the Knowledge and Attitudes of EM Physicians Towards Prescribing Buprenorphine/Naloxone for Opioid Use Disorder
Authors: Zosel Amy , Hernandez-Meier Jennifer , Owen Julie
Published: September 2024

Background: Opioid overdose continues to be a major cause of morbidity and mortality. Buprenorphine is an important treatment for patients with opioid-use disorder (OUD) and initiation in the emergency department (ED) has been shown to improve outcomes for these patients. 
Purpose/hypothesis: Our objective was to assess the impact of a three-pronged education package on the knowledge and attitudes of emergency physicians towards using buprenorphine for treatment of OUD. 
Procedures/data/observations: We developed a three-pronged educational package including background rationale for OUD treatment with buprenorphine, an evidence-based ED buprenorphine induction pathway and electronic medical record tools. This package was deployed to providers in an urban academic ED. A voluntary confidential pre-post survey was administered. Using a 6-point Likert Scale, participants were asked about their understanding, experience, and confidence with prescribing.
Conclusions/applications: A one-hour, three-pronged educational package changed the attitudes of emergency physicians towards buprenorphine treatment and demonstrated an increase in willingness and confidence to prescribe it for patients with OUD. Our findings suggest that healthcare entities that wish to boost buprenorphine prescribing can impact willingness and confidence to prescribe with a short education package.
Attitudinal barriers to buprenorphine prescription and former waiver training
Authors: Gannon Michael P. , Tello Monique , Wakeman Sarah , Charles Jean-Pierre , Lipsitz Stuart , Samal Lipika
Published: September 2024

Objective: Opioid use disorder (OUD) can be effectively treated with buprenorphine maintenance. Recent changes in federal policy have removed the requirement for physicians to complete additional training to apply for a Drug Enforcement Administration (DEA) waiver to prescribe buprenorphine. At that time, few primary care providers (PCPs) had completed the training for a DEA waiver to prescribe buprenorphine. Our goal was to identify addressable barriers that may persist despite updates to federal legislation.
Design: A 42-item survey was distributed to 662 physicians and nurse practitioners at two academic medical centers with 100 respondents.
Setting: The survey was sent via email and administered anonymously through SurveyMonkey.
Patients and participants: All participants were PCPs, and all PCPs at the two academic medical centers were eligible to participate.
Interventions: PCPs responded to the survey by answering questions online.
Main outcome measures: PCPs answered questions regarding previous buprenorphine waiver training status, local OUD prevalence, the effectiveness of OUD treatment modalities, and previous barriers to training.
Results: Respondents were compared using descriptive statistics and logistic regression. Of the 100 respondents (response rate: 15 percent), 69 percent had not completed the training. Ninety-nine percent of PCPs agreed that OUD was an issue in their area, 94 percent saw patients with OUD, and 91 percent rated buprenorphine maintenance as a very effective treatment for OUD. Previously waivered and nonwaivered providers did not differ in their responses to these questions. Those who had been waivered were less likely to say they did not see enough patients with OUD to justify training (odds ratio [OR] 0.267, p = 0.005) and were less likely to express concern about allowing patients with OUD into their practice (OR 0.348, p = 0.020) than PCPs who had applied for the DEA waiver.
Conclusions: Despite nonwaivered PCPs recognizing OUD's prevalence, they were concerned about allowing patients with OUD into their practice and said there were not enough patients to justify training. This suggests that attitudinal barriers are the most appropriate target for current intervention.
Implementing a text-message-based intervention to increase access to naloxone for patients on chronic opioid therapy
Authors: Weiner Scott G. , Alrakawi Salah , Kelley Morgan , Shahani Amrita Chabria , Silva Cheryl , McCatty Andrew D. , Lasden Danielle , Sivashanker Karthik
Published: September 2024

Objective: To implement a text-message-based intervention for primary care patients taking chronic opioid therapy to increase access to naloxone.
Design: Retrospective analysis of a hospital quality improvement initiative.
Setting: This study was conducted with selected primary care practices affiliated with an academic medical center between March and July 2022.
Participants: Patients were eligible for receiving the intervention if they had chronic (≥90 days) opioid use of ≥50 morphine milligram equivalents/day and had not previously opted out of receiving text messages.
Interventions: Text messages were sent to patients inquiring about interest in obtaining a naloxone kit, which prompted a pharmacist to contact the patient and provide the medication by mail.
Main outcome measures: We examined response rates to text messages and numbers of naloxone kits dispensed.
Results: There were 243 patients identified who were sent the text message. Of these, 230 (94.7 percent) had a primary language of English, 150 (61.7 percent) were White, and 57 (23.5 percent) were Black/African American. The mean age was 57.3 years. After receiving the text messages, 64 (26.3 percent) of the 243 patients responded with “unsubscribe.” Thirty-five (14.4 percent) patients responded to the message, and 18 patients (51.4 percent of those who responded or 7.4 percent of all included patients) wanted the medication and were contacted by a pharmacist who filled and mailed the prescription to them.
Conclusions: A text-message-based program to provide naloxone to patients with chronic opioid use was feasible. However, fewer than 15 percent of patients responded to the message, and just half of those wanted the medicine.
Prescription opioids following herpes zoster: An observational study among insured adults, United States, 2007-2021
Authors: Dooling Kathleen , Leung Jessica , Bohm Michele K.
Published: September 2024

Background: The opioid overdose epidemic has resulted in hundreds of thousands of overdose deaths in the United States (US). One indication for opioids is herpes zoster (HZ)—a common painful condition with an estimated 1 million cases occurring annually in the US.
Objective: We aimed to characterize prescription opioid claims and trends among patients with HZ who were previously opioid naive.
Design: We used a cohort study involving three insurance claims databases in the US. We included all beneficiaries 18-64 years (commercial and Medicaid) and beneficiaries 65 years and older (Medicare) who were diagnosed with incident HZ during 2007-2021. We determined the proportion of opioid-naive patients with HZ who filled an opioid prescription within 30 days and 180 days following HZ diagnosis. We also examined trends over the study period, proportion receiving moderate, high dosages (50-89 morphine milligram equivalent [MME], and ≥90 MME per day), and long-term receipt.
Results: Among all three insurance databases, 2,595,837 patients had an incident episode of HZ and were opioid naive during the prior 6 months. Within 30 days following HZ, 623,515 (24 percent) filled a prescription for an opioid. The percentage with an opioid claim declined during 2007-2021 for all groups; 65 percent for commercially insured patients, 51 percent for Medicaid-insured patients, and 60 percent for Medicare-insured patients. Approximately 8-15 percent of all beneficiaries received moderate and 2-6 percent received high dosage opioids. Long-term prescription opioid use of at least 6 months was found in 7-12 percent of the patients.
Conclusions: Continuing trends in judicious opioid prescribing as well as use of recommended HZ vaccines may decrease opioid prescriptions for HZ.
Fentanyl dose-sparing in polyarthritic rats requires full agonism at 5-HT1A receptors: Comparison between NLX-112, (±)8-OH-DPAT, and buspirone
Authors: Depoortere Ronan , Bardin Laurent , Newman-Tancredi Adrian
Published: September 2024

Background: NLX-112 (a.k.a. F13640, befiradol) is a highly selective and fully efficacious agonist at 5-hydroxytryptamine (5-HT1A) receptors. It has been shown to be robustly and potently active in nociceptive, neuropathic and traumatic pain models in rats and mice. In particular, NLX-112 decreases oral fentanyl self-administration (FSA) in polyarthritic rats, ie, it has opioid dose-sparing effects.
Objective: To examine if the dose-sparing effects of NLX-112 in polyarthritic rats are shared by other 5-HT1A ligands: the prototypical 5-HT1A receptor agonist 8-HYDROXY-2-(DI-n-PROPYLAMINO)TETRALIN ((±)8-OH-DPAT), and the 5-HT1A receptor partial agonist and weak dopamine D2 receptor blocker, buspirone.
Design: Polyarthritis was induced by inoculating rats with heat-killed Mycobacterium butyricum. They then had access to either a fentanyl (0.008 mg/mL) or a sweetened solution in their home cage. NLX-112, (±)8-OH-DPAT, or buspirone was administered via an osmotic minipump (5 μL/h) during a 2-week infusion period from day 14 to day 28 post-inoculation with Mycobacterium butyricum. Control infusions consisted of sterile 0.9 percent NaCl.
Results: NLX-112 (0.63 mg/day) significantly decreased FSA by 47 percent and increased total fluid consumption (TFC) by 7 percent (vehicle-loaded minipumps as controls). Both (±)8-OH-DPAT and buspirone (0.63 and 2.5 mg/day, respectively) failed to reduce FSA; (±)8-OH-DPAT did not modify TFC, while buspirone significantly decreased it by 17 percent.
Conclusions: These results suggest that oral FSA dose-sparing effect, in this rat polyarthritis pain model, requires high efficacy activation of 5-HT1A receptors, such as that afforded by NLX-112. By contrast, the agonist efficacy of (±)8-OH-DPAT and buspirone seems insufficient for FSA dose-sparing.
Volume 20, Number 4
Authors: Opioid Management Journal of
Published: September 2024

July/August 2024
Hydroxytyrosol has a cardioprotective effect through dardarin and asprosin
Authors: Kocaman Nevin , Onat Elif
Published: September 2024

Introduction

In this investigation, we explored the potential involvement of dardarin (LRRK2) and asprosin in the protective efficacy of hydroxytyrosol (HT) against heart damage induced by corn syrup in rats.

Material and methods

The research was conducted at the Adıyaman University Experimental Research Center during the period from December 8, 2021, to July 12, 2023. Rats were categorized into four groups (n = 6) as follows: control, HT, corn syrup, and corn syrup + HT. Over a span of 6 weeks, rats were administered water infused with 30% corn syrup. Simultaneously, a 4 ml/kg/day solution containing HT was orally administered, both independently and in conjunction with corn syrup, throughout the 6-week period. The molecular parameters of LRRK2 and asprosin in the cardiac tissue were assessed through histopathological examination.

Results

In this study, it was observed that the LRRK2 level increased and the asprosin level decreased in the control group as a result of administration of corn syrup. After HT treatment, the LRRK2 level decreased non-significantly, while the asprosin level increased significantly. No difference was seen in the HT-only group compared to the control.

Conclusions

The protective effect of HT against damage to the heart due to corn syrup consumption may be mediated by LRRK2 and asprosin.
Mehr Effizienz in der Trockenpartie
Authors: Buschmeier Nicole , Endo Shuhei
Published: September 2024

Das japanische Unternehmen Maintech wurde 1967 gegründet und liefert – für eine nachhaltige Papierproduktion – weltweit Lösungen zur Passivierung in der Trockenpartie von Papiermaschinen. Als Erfinder der Passivierung im Bereich der Trockenpartie hat Maintech über 1000 Passivierungssysteme weltweit installiert (Stand: 01.04.2024). Autoren: Shuhei Endo (Maintech Europe GmbH), Nicole Buschmeier
Rückgewinnung von Energie und Wasser
Authors: Buschmeier Nicole , Cristaldi Donato
Published: September 2024

Die Anaergia Technologies ist Tochter der Anaergia Gruppe mit Sitz in Kanada, einem der Weltmarktführer in der Rückgewinnung von Organik zur Erzeugung von Energie, Wasser und Düngemittel aus nahezu jedem Abfallstrom. Autoren: Nicole Buschmeier, KPNB; Donato Cristaldi, Geschäftsführer Anaergia Technologies GmbH
Nachhaltigkeitsverbesserung und Kostenreduzierung im Bereich von Cleaneranlagen
Authors: Leitner Wolfgang , Kügele Manfred
Published: September 2024

Autoren: Wolfgang Leitner, Direktor CIT Hamburger Containerboard; Manfred Kügele, Senior Consultant, HGH Kuegele GmbH / Austria (Vortrag auf der Paper & Biorefinery Graz, 15./ 16. May 2024)
Interlingual Syntactic Parsing: An Optimized Head-Driven Parsing for English to Indian Language Machine Translation
Authors: Chaudhary Pavan Kurariya, Prashant , Bodhankar Jahnavi , Singh Lenali , Kumar Ajai
Published: September 2024

In the era of Artificial Intelligence (AI), significant progress has been made by enabling machines to understand and communicate in human languages. Central to this progress are parsers, which play a vital role in syntactic analysis and support various Natural language Processing (NLP) applications, including Machine Translation and sentiment analysis. This paper introduces a robust implementation of an optimized Head-Driven Parser designed to advance NLP capabilities beyond the limitations of traditional Lexicalized Tree Adjoining Grammar (L-TAG) based Parser. Traditional parser, while effective, often struggle with the capturing complexities of natural languages, especially translation between English to Indian languages. By leveraging Bi-directional approach and Head-Driven techniques, this research offers a revolutionary enhancement in parsing frameworks. This method not only improves performance in syntactic analysis but also facilitates complex tasks such as discourse analysis and semantic parsing. This research involves experimentation the Bi-Directional Parser on a dataset of 15,000 sentences, resulting a reduction in derivation variations compared to conventional TAG Parsers. This advancement highlights how Head-Driven Parsing can overcome traditional constraints and provide more reliable linguistic analysis. The paper demonstrates how this new implementation not only builds on the strengths of L-TAG but also addresses its limitations and contributes to expanding the scope of Tree Adjoining Grammarbased methodologies and advancing the field of Machine Translation.