bluuebunny/crossref_metadata_2025 huggingface dataset:
Small ruminant neonatal nutrition
Authors: Van Saun Robert J.
Published: July 2023

Loss of preweaned lambs and kids is a significant economic burden on small ruminant enterprises. Nutrition is an impor­tant factor impacting neonatal losses. Four critical nutritional phases can impact neonatal viability: maternal gestational diet adequacy, colostrum feeding, milk feeding and rumen develop­ment, and post-weaning feeding practices. As with any farm animal, consumption of adequate amounts of high-quality co­lostrum is the single most critical event in the life of a small ruminant. In contrast to dairy cattle, no guidelines defining volume and immunoglobulin (Ig) content for sheep and goat co­lostrum to ensure adequate passive transfer are available. Simi­larly, there are no well-defined criteria for determining success or failure of passive transfer in sheep and goats. The second most critical event of the neonatal small ruminant is adequate rumen development to facilitate a smooth transition during the weaning process. This presentation will address these 4 nutri­tional phases with emphasis on colostrum management prac­tices and rumen development as methods to improve neonatal survivability and viability.
Determination of milk concentrations and pharmacokinetics of salicylic acid following acetylsalicylic acid (aspirin) administration in postpartum dairy cows
Authors: Fritz B. R. , Kleinhenz M. D. , Montgomery S. R. , Magnin G. , Martin M. S. , Weeder M. , Curtis A. K. , Coetzee J. F.
Published: July 2023

The objectives of this descriptive study were to 1) describe the pharmacokinetics of salicylic acid (SA) in the milk and plasma of postpartum dairy cattle following oral administration of ace­tylsalicylic acid (ASA) (aspirin); 2) to estimate a recommended milk withdrawal period for dairy cattle treated with ASA; and 3) to determine the impact of ASA administration on plasma prostaglandin E2 metabolite (PGEM) concentrations. Adminis­tration of non-steroidal anti-inflammatory drugs, such as the widely available drug aspirin, or acetylsalicylic acid (ASA), may improve health and milk production in postpartum dairy cows. However, plasma pharmacokinetic data for salicylic acid (SA), the active metabolite of ASA, are unrepresentative of lactating dairy cows and current treatment regimens, and there are cur­rently no published milk residue and minimal pharmacody­namic data available for ASA or SA in dairy cows.
Effect of an additional GnRH 2 d after the initiation of the Resynch-25 program on pregnancy per artificial insemination in lactating dairy cows
Authors: Leao I. M. R. , Carbajal A. , Narciso C. , El Azzi M. , Consentini C. E. C. , Sartori R. , Martins J. P. N.
Published: July 2023

Timed-AI protocols for the reinsemination of nonpregnant cows significantly reduce the interval between inseminations (AI) in lactating dairy cows. One of the most used programs is the Resynch-25, which starts Ovsynch on d 25 after previous AI in all cows, and only nonpregnant cows continue with the pro­gram on d 32 after previous AI. Low ovulatory response to d 25 GnRH administration can compromise the proportion of cows synchronized to the program and pregnancy per AI (P/AI) after timed-AI. One of the factors that can affect ovulatory response to this d 25 GnRH is the stage of antral follicle development at the time of treatment. For instance, non-dominant follicles can­not ovulate due to a lack of LH receptors in the granulosa cells. Thus, we hypothesized that adding an extra GnRH 2 d after d25 GnRH would increase P/AI to the Resynch-25 program. Our ob­jective was to determine the effect of an additional GnRH 2 d after initiating the Resynch-25 program on P/AI.
Assessment of systemic inflammation following oral calcium supplementation in postpartum dairy cows – a pilot-scale randomized controlled trial
Authors: Couto Serrenho R. , Morrison E. , Bruinje T. C. , LeBlanc S. J.
Published: July 2023

A new line of thinking is emerging to link inflammation with calcium metabolism. Around parturition, dairy cows inevitably and perhaps necessarily experience some degree of systemic inflammation, but excessive or dysregulated inflammation likely contributes to inflammatory disease. Immune activa­tion decreases blood Ca, so greater extracellular Ca availability may potentiate or sustain inflammation. Hypocalcemia may be an adaptive response to inflammation. The objective of this study was to investigate a possible role of supplemental calcium (Ca) in postpartum systemic inflammation in dairy cows. We hypothesized that in clinically healthy multiparous cows, post­partum administration of supplemental Ca may increase serum concentrations of markers of inflammation.
Prevalence of antimicrobial resistance (AMR) in fecal Escherichia coli and Enterococcus spp. isolated from beef cow-calf operations in northern California and associations with farm practices
Authors: Morris C. , Wickramasingha D. , Abdelfattah E. , Pereira R. , Okello E. , Maier G.
Published: July 2023

Antimicrobials are necessary for treatment of bacterial infec­tions in both humans and animals; however, antimicrobial re­sistance (AMR) is becoming a public health threat. As a result, antimicrobial use in food animals has come under scrutiny. En­terococcus and E. coli are both part of the normal flora of the bo­vine gastrointestinal tract, with the potential to cause disease, and often serve as sentinels for AMR. Studies investigating AMR in cow-calf operations are sparse but are essential for un­derstanding of AMR in the beef industry. The objective of this cross-sectional study was to assess prevalence of AMR levels in E. coli and Enterococcus spp. in beef cattle of different life stages, breeds, pasture type exposure and antibiotic drug exposure on a herd and individual level.
Evaluating the timing of bovine respiratory disease morbidity and mortality in feedlot cattle by first treatment, fatal disease onset, and days from first treatment to death
Authors: Smith K. J. , Amrine D. E. , Larson R. L. , Szaz J. I. , Waggoner J. W. , While B. J. , Theurer M. E.
Published: July 2023

Little research has evaluated risk factors influencing the timing of bovine respiratory disease (BRD); the main focus of previ­ous BRD research has been on environmental and demographic factors influencing disease frequency. The study objective was to descriptively evaluate typical BRD temporal patterns for cat­tle in U.S. Great Plains feedyard systems.
Impact of oral calcium bolus timing on milk production and health events in early lactation Holstein cows
Authors: Seely C. , Wilbur C. , Fang K. , McArt J.
Published: July 2023

Treatment of subclinical hypocalcemia by administration of an oral Ca bolus at 0 and 24 h post calving has shown limited suc­cess in increasing production and minimizing adverse health events. Our objective was to explore the effect of delayed oral Ca bolus supplementation on milk production and disease inci­dence and the impact of delayed oral Ca bolus supplementation on postpartum blood Ca dynamics. We conducted a random­ized controlled trial on multiparous Holstein cows (n = 998) from 4 herds in New York. At calving, cows were randomly assigned to 1 of 3 treatment groups: 1) no supplemental Ca at or around parturition (CON; n = 343), 2) an oral Ca bolus con­taining 43 g Ca at calving and 24 h later (BOL-C; n = 330), or 3) an oral Ca bolus containing 43 g Ca at 48 and 72 h post-calving (BOL-D; n = 325). We created generalized linear mixed models to analyze differences in serum total Ca (tCa) at 1 and 4 DIM and milk yield for the first 10 wk of lactation between treatment groups and multivariable Poisson regression models to analyze adverse event outcomes (metritis, displaced abomasum, died or sold, or a combination of the above) in the first 30 DIM. Serum tCa was lower at 1 than 4 DIM (P < 0.001; 1.91 [95% CI = 1.90, 1.93] mmol/L and 2.26 [95% CI = 2.24, 2.28] mmol/L, respectively), and there was no difference in tCa between treatment groups (P = 0.16). Milk yield increased by week (P < 0.001) and was not af­fected by treatment (P = 0.18; CON: 48.9 [95% CI = 48.1, 49.8] kg, BOL-C: 48.3 [95% CI = 47.5, 49.1] kg, BOL-D: 49.3 [95% CI = 48.5, 50.1] kg). A treatment by parity group interaction for milk yield (P = 0.005) showed that BOL-D parity 3 cows produced more milk than BOL-D cows in parity group 2 or 4+ as well as CON and BOL-C cows in parity groups 2, 3 or 4+. Incidence of adverse events did not differ between treatments (P = 0.39; CON: 9.5%, BOL-C: 8.1%, BOL-D: 11.5%). Our findings suggest that delaying oral Ca bolus supplementation has limited impact on blood Ca concentrations but may be beneficial to cohorts of cows as a tar­geted prophylactic supplement to support milk production.
Impact of plane of nutrition and analgesic treatment on wound healing and pain following cautery disbudding in preweaned dairy calves
Authors: Reedman C. N. , Duffield T. F. , DeVries T. J. , Lissemore K. D. , Adcock S. , Tucker C. , Parson S. , Winder C. B.
Published: July 2023

Nutrition has been reported to be a crucial part of the wound healing process in humans as malnutrition has been well-doc­umented to impede wound healing; however, this has not been evaluated in disbudding wounds in calves. Although it is be­coming more common to feed an increased nutritional plane to young dairy calves, 33% of Canadian producers in a 2015 survey were still feeding calves low levels of milk (< 6 L/d). The objec­tive of this study was to determine the impact of a biologically normal plane of nutrition compared to a limited plane on the primary outcome wound healing, and one dose of nonsteroidal anti-inflammatory drug (NSAID) compared to 2 on the second­ary outcomes: lying behaviour, haptoglobin concentrations, and mechanical nociceptive threshold (MNT) in calves disbud­ded via cautery iron.
Telemedicine vignettes as a platform to enhance the quantity and diversity of clinical case exposure for veterinary students
Authors: Fajt V. R. , Teller L. M. , Stillisano J. , Lubbers B.
Published: July 2023

The transition from veterinary school to practice can be chal­lenging for a number of reasons, including lack of experience with managing primary care cases. Case-based approaches are often used to enhance student engagement but may fall short of increasing competence and confidence due to the nature of tertiary-care cases usually presenting to veterinary teaching hospitals.
Impact of the host transcriptome on bovine respiratory disease treatment during backgrounding
Authors: Green M. M. , Woolums A. R. , Karisch B. B. , Harvey K. M. , Scott M. A. , Capik S. F.
Published: July 2023

Bovine respiratory disease (BRD) continues to be problematic across the beef cattle industry. Marketing strategies made prior to backgrounding may shift the initial treatment for BRD into a different phase of production, and the importance of host gene expression on BRD incidence is poorly understood. Whole blood transcriptomes measured on arrival could inform our ability to better manage these cattle and predict BRD risk. Our objective was to compare host transcriptomes as measured on arrival at a backgrounding facility on the probability of being treated for BRD during the following 45 days on feed.
Johne’s disease in beef cattle: Correlation of serum ELISA and fecal PCR results from clinical cases and herd surveillance
Authors: Magstadt D. , Kreuder A. J. , Hensley L. , McKeen L. , Baum D. , Gimenez-Lirola L. , Gauger P. C.
Published: July 2023

Johne’s disease is caused by Mycobacterium avium ssp. paratu­berculosis (MAP) and can be a costly and frustrating disease in beef herds. Clinical Johne’s disease in cattle arises years after inoculation as diarrhea and progressive weight loss. Prior to reaching clinical status, subclinically infected cattle can shed bacteria into their environment, leading to continued spread of the disease within herds. The duration of subclinical infection is highly variable, and the humoral immune response and the amount of fecal shedding of MAP can vary greatly between in­dividuals and throughout the year. Currently available diagnos­tic tests (serum ELISA, fecal PCR, fecal culture) each have sig­nificant limitations. Assays may differ in their utility depending on whether they are used to confirm clinical cases of Johne’s disease or to screen healthy cattle for potential infection.
Evaluation of the stress-reducing effect of injectable trace minerals in beef calves
Authors: Megahed A. , Bittar J. , Palomares R. , Mercadante V. , Dias N.
Published: July 2023

Very few studies have shown that trace minerals supplementa­tion may have stress-reducing effects in humans. In beef cattle, to the best of our knowledge, no available information about the mechanistic effects of injectable trace-minerals supple­mentation (ITM) on beef calf’s stress response. The aim of the current study was, therefore, to address this gap in knowledge by evaluating the stress-mitigation effects of ITM in beef calves exposed to different types of stress.
Maintenance of the last step of the cold chain: on-farm refrigerator storage and performance
Authors: Fallness C. A. , Rollin E. , Heins B. D. , Berghaus R. D.
Published: July 2023

Failure of the cold chain and thermal damage to refrigerated vaccines can result in losses for cattle owners and safety issues for cattle. The primary objectives of this study were to quantify characteristics of refrigerator operating temperatures on re­gional dairy and veterinary operations, including the percent­age of time that refrigerators spent outside the recommended temperature interval (RTI) of 36°F to 46°F (2°C to 8°C) for vac­cine storage, the mean daily temperature range (MDTR), and identify variables associated with those characteristics.
Pilot study to investigate the impacts of cannabinoids from industrial hemp and repeated transportation events on cattle health and immune status
Authors: Fritz B. R. , Kleinhenz M. D. , Griffin J. , Weeder M. , Leslie A. A. , Johnson B. T. , Curtis A. K. , Coetzee J. F.
Published: July 2023

The segmentation of the cattle industries necessitates regular transportation. Transport alters immune and stress biomark­ers in cattle. The passage of the 2018 Farm Bill excluded indus­trial hemp (IH; Cannabis sativa, ≤ 0.3% tetrahydrocannabinol) from the USDA marijuana definition and DEA Schedule I sta­tus, enabling USDA-authorized IH research to determine the sustainability of IH cultivation. Data on the utility of IH for cattle transport has not been described. The object of the cur­rent study was to evaluate the effects of oral IH on immune and stress biomarkers in cattle being transported considerable distances.
Pilot study: Refining a culture-guided selective dry cow therapy program to enhance antimicrobial stewardship on dairy farms
Authors: Godden S. M. , Royster E. , Leonard E. , Albrecht D. , Timmerman J.
Published: July 2023

Selective dry cow therapy (SDCT) programs typically use either milk culture or algorithm methods to identify cows with a high risk of infection, and thereby warranting antimicrobial therapy (AMX) at dry off (DO). Multiple studies have demonstrated that SDCT programs can maintain future cow health while signifi­cantly reducing antimicrobial use (AMU), as compared to blan­ket DCT (BDCT). However, we may be able to further reduce AMU at DO by targeting only specific types of intramammary infection (IMI) that will benefit from AMX. A recent meta-analysis concluded that IMI caused by Streptococcus spp. or Streptococcus-like organisms (SSLO) do benefit from DC therapy, while IMI caused by coliform or non-aureus Staph spp. (NAS) do not. Similarly, IMI caused by other Gram-positive bacteria, in­cluding S. aureus, occur with a relatively low frequency in most herds, and often do not respond to AMX. The Minnesota Easy® Focus® media is selective for SSLO growth in milk samples. This pilot study aimed to evaluate the effect of a SDCT program that identifies and treats only IMI caused by SSLO (vs. BDCT) on quarter health and AMU.
The effect of pain mitigation during cautery disbudding of neonatal goat kids on subsequent health and performance
Authors: Burke E. M. , Barrell E. A. , Ventura B. A. , Menn T. M. , Bakke H. , Thomas M. M. , Knauer W. A.
Published: July 2023

Disbudding of goat kids is a necessary but painful procedure that causes both acute and longer-term pain. Currently, most goat kids are disbudded using cautery without any pain control. Pain mitigation has been shown to improve measures of acute pain response, but little is known about the effects on longer term health and performance outcomes. The objective of this study was to investigate the effect of pain mitigation using a combina­tion of xylazine, meloxicam and lidocaine on growth and health outcomes compared to kids disbudded with no pain control.
Analytic neutrino oscillation probabilities
Authors: Fong Chee Sheng
Published: July 2023

In the work, we derive exact analytic expressions for (3+N)(3+N)-flavor neutrino oscillation probabilities in an arbitrary matter potential in term of matrix elements and eigenvalues of the Hamiltonian. With the analytic expressions, we demonstrate that nonunitary and nonstandard neutrino interaction scenarios are physically distinct: they satisfy different identities and can in principle be distinguished experimentally. The analytic expressions are implemented in a public code NuProbe, a tool for probing new physics through neutrino oscillations.
Carta editorial
Authors: Calabrese Claudio César , Galindo Cruz Pablo , Hurtado Domínguez Rafael
Published: July 2023

Carta editorial
The Construction of A Multi-epitope Vaccine Against Klebsiella pneumoniae Using in silico Approach
Authors: Wonggo Dhammiko , Wahjudi Mariana
Published: July 2023

Background: Klebsiella pneumoniae is one of the bacteria that causes pneumonia infection. Even though the number of pneumonia cases is relatively high and has become a global problem, there is still no vaccine available to prevent this disease. This study was aimed to design a multi-epitope vaccine design through an in silico approach, against K. pneumoniae.Materials and method: Vaccine candidate was constructed based on proteins of K. pneumoniae. These proteins were analyzed to identify the antigens sequence for multi-epitope vaccine design. The constructed vaccine was predicted for allergenicity, toxicity, population coverage, and its physicochemical properties. The vaccine structure was then docked with the toll like receptor 2 (TLR2) molecule to show the interaction. Expression analysis and cloning of the constructed vaccine was carried out in the pET-28a vector using SnapGene.Results: The vaccine was 567 amino acids long, consisting of Cholera Toxin Subunit B as an adjuvant, 6 B-cell epitopes, 11 cytotoxic T-cell epitopes, and 10 helper T-cell epitopes connected with the appropriate linker. Epitopes analysis showed that the vaccine will be a non-toxic, has high antigenicity, but non-allergenic. The vaccine was predicted to be stable, hydrophilic, and had a low risk of triggering autoimmune response. The vaccine molecule was compatible to humans TLR2 molecule. Furthermore, visualization of the candidate vaccine protein on pET-28a showed that the vaccine protein might be expressed correctly.Conclusion: The construction of multi-epitope vaccine has been developed, which might be a good vaccine candidate, containing 6 B-cell epitopes, 11 CTL epitopes, and 10 HTL epitopes. The construct may help scientists to experimentally formulate multi-epitope vaccine against K. pneumoniae in the future.Keywords: in silico, Klebsiella pneumoniae, multi-epitope, vaccine
Prospects for New Antibiotics Discovered through Genome Analysis
Authors: Singh Arun Kumar , Malviya Rishabha , Sharma Rishav
Published: July 2023

Antibiotic-resistant illnesses are on the rise worldwide, and the pipeline for developing new antibiotics is drying up. As a result, researchers need to create novel compounds with antimicrobial action. Recent decades have seen a dearth of novel antibiotics because of the reliance on conventional empirical screening procedures using both natural and synthetic chemicals to find them. There is hope that the massive amount of bacterial genome sequence data that has become accessible since the sequencing of the first bacterial genome more than 20 years ago might help lead to the development of new antibiotic drugs. Genes with significant levels of conservation both within and between bacterial species can be found using comparative genomic techniques; these genes may be involved in essential bacterial functions. Bioactive chemicals found in natural products have been successfully used in treating everything from infectious diseases to cancer, but over the past 20-30 years, the effectiveness of screening methods based on fermentation has decreased. Researchers urgently need answers to the unmet demand for bacterial infection resistance. Now more than ever, with the advent of cheap, high-throughput genomic sequencing technology, natural product discovery can be revitalized. Using bioinformatics, investigators may foretell whether or not a certain microbial strain would generate compounds with novel chemical structures, which may have novel modes of action in inhibiting bacterial growth. This manuscript describes how this potential might be utilised, with a particular emphasis on manipulating the expression of dormant biosynthetic gene clusters that are hypothesised to encode new antibiotics. Additionally, it consolidates the work of the past and the present to utilise bacterial genomic data in the identification and development of new antibiotics.
Role of Blockchain in Healthcare Sector
Authors: Abbas Sheik Abdullah , Jothikumar Karthikeyan , Ansari Arif
Published: July 2023

The domain of bio-medical engineering is facing significant challenges and issues due to data management, data attribution, data security, data availability and privacy. The mechanism of blockchain corresponds to a time-stamped set of data records that is maintained and managed by a cluster/group of the computer system. The collection of cluster groups is secured and protected by cryptographic values, which are often said to be the chains. The growth of blockchain has progressed in a variety of applications in terms of asset management, IoT, smart devices, supply chains, public data validations, and personal identification. Even though the growth has progressed in different emerging disciplines, the impact of blockchain in technology-based biomedical engineering created a vast difference and incorporation in various fields of operation. In a medical data management system, an old audit trail is mostly needed to perform data operations such as insert, delete, and update. Blockchain is, therefore, suitable for the process concerning fixed ledger to record and update critical information services. This chapter completely focuses on the role of blockchain in biomedical engineering applications.
Roles of Health Literacy in Relation to Social Determinants of Health and Recommendations for Informatics-Based Interventions: Systematic Review (Preprint)
Authors: Bindhu Shwetha , Nattam Anunita , Xu Catherine , Vithala Tripura , Grant Tiffany , Dariotis Jacinda K , Liu Hexuan , Wu Danny T Y
Published: July 2023

BACKGROUND

Health literacy (HL) is the ability to make informed decisions using health information. As health data and information availability increase due to online clinic notes and patient portals, it is important to understand how HL relates to social determinants of health (SDoH) and the place of informatics in mitigating disparities.

OBJECTIVE

This systematic literature review aims to examine the role of HL in interactions with SDoH and to identify feasible HL-based interventions that address low patient understanding of health information to improve clinic note-sharing efficacy.

METHODS

The review examined 2 databases, Scopus and PubMed, for English-language articles relating to HL and SDoH. We conducted a quantitative analysis of study characteristics and qualitative synthesis to determine the roles of HL and interventions.

RESULTS

The results (n=43) were analyzed quantitatively and qualitatively for study characteristics, the role of HL, and interventions. Most articles (n=23) noted that HL was a result of SDoH, but other articles noted that it could also be a mediator for SdoH (n=6) or a modifiable SdoH (n=14) itself.

CONCLUSIONS

The multivariable nature of HL indicates that it could form the basis for many interventions to combat low patient understandability, including 4 interventions using informatics-based solutions. HL is a crucial, multidimensional skill in supporting patient understanding of health materials. Designing interventions aimed at improving HL or addressing poor HL in patients can help increase comprehension of health information, including the information contained in clinic notes shared with patients.
Assessing the Utility, Impact, and Adoption Challenges of an Artificial Intelligence–Enabled Prescription Advisory Tool for Type 2 Diabetes Management: Qualitative Study (Preprint)
Authors: Yoon Sungwon , Goh Hendra , Lee Phong Ching , Tan Hong Chang , Teh Ming Ming , Lim Dawn Shao Ting , Kwee Ann , Suresh Chandran , Carmody David , Swee Du Soon , Tan Sarah Ying Tse , Wong Andy Jun-Wei , Choo Charlotte Hui-Min , Wee Zongwen , Bee Yong Mong
Published: July 2023

BACKGROUND

The clinical management of type 2 diabetes mellitus (T2DM) presents a significant challenge due to the constantly evolving clinical practice guidelines and growing array of drug classes available. Evidence suggests that artificial intelligence (AI)–enabled clinical decision support systems (CDSSs) have proven to be effective in assisting clinicians with informed decision-making. Despite the merits of AI-driven CDSSs, a significant research gap exists concerning the early-stage implementation and adoption of AI-enabled CDSSs in T2DM management.

OBJECTIVE

This study aimed to explore the perspectives of clinicians on the use and impact of the AI-enabled Prescription Advisory (APA) tool, developed using a multi-institution diabetes registry and implemented in specialist endocrinology clinics, and the challenges to its adoption and application.

METHODS

We conducted focus group discussions using a semistructured interview guide with purposively selected endocrinologists from a tertiary hospital. The focus group discussions were audio-recorded and transcribed verbatim. Data were thematically analyzed.

RESULTS

A total of 13 clinicians participated in 4 focus group discussions. Our findings suggest that the APA tool offered several useful features to assist clinicians in effectively managing T2DM. Specifically, clinicians viewed the AI-generated medication alterations as a good knowledge resource in supporting the clinician’s decision-making on drug modifications at the point of care, particularly for patients with comorbidities. The complication risk prediction was seen as positively impacting patient care by facilitating early doctor-patient communication and initiating prompt clinical responses. However, the interpretability of the risk scores, concerns about overreliance and automation bias, and issues surrounding accountability and liability hindered the adoption of the APA tool in clinical practice.

CONCLUSIONS

Although the APA tool holds great potential as a valuable resource for improving patient care, further efforts are required to address clinicians’ concerns and improve the tool’s acceptance and applicability in relevant contexts.
Designing and Developing Online Training for Diabetes Prevention Program Coaches Using an Integrated Knowledge Translation Approach: Development and Usability Study (Preprint)
Authors: Cranston Kaela D , Grieve Natalie J , Dineen Tineke E , Jung Mary E
Published: July 2023

BACKGROUND

e-Learning has rapidly become a popular alternative to in-person learning due to its flexibility, convenience, and wide reach. Using a systematic and partnered process to transfer in-person training to an e-learning platform helps to ensure the training will be effective and acceptable to learners.

OBJECTIVE

This study aimed to develop an e-learning platform for Small Steps for Big Changes (SSBC) type 2 diabetes prevention program coaches to improve the viability of coach training.

METHODS

An integrated knowledge translation approach was used in the first 3 stages of the technology-enhanced learning (TEL) evaluation framework to address the study objective. This included three steps: (1) conducting a needs analysis based on focus groups with previously trained SSBC coaches, meetings with the SSBC research team, and a review of research results on the effectiveness of the previous in-person version of the training; (2) documenting processes and decisions in the design and development of the e-learning training platform; and (3) performing usability testing. Previously trained SSBC coaches and the SSBC research team were included in all stages of this study.

RESULTS

Step 1 identified components from the in-person training that should be maintained in the e-learning training (ie, a focus on motivational interviewing), additional components to be added to the e-learning training (ie, how to deliver culturally safe and inclusive care), and mode of delivery (videos and opportunities to synchronously practice skills). Step 2 documented the processes and decisions made in the design and development of the e-learning training, including the resources (ie, time and finances) used, the content of the training modules, and how coaches would flow through the training process. The design and development process consisted of creating a blueprint of the training. The training included 7 e-learning modules, the learning modalities of which included narrated demonstration videos and user-engaging activities, a mock session with feedback from the research team, and a final knowledge test. Step 3, usability testing, demonstrated high levels of learnability, efficiency, memorability, and satisfaction, with minor bugs documented and resolved.

CONCLUSIONS

Using an integrated knowledge translation approach to the technology-enhanced learning evaluation framework was successful in developing an e-learning training platform for SSBC coaches. Incorporating end users in this process can increase the chances that the e-learning training platform is usable, engaging, and acceptable. Future research will include examining the satisfaction of coaches using the SSBC coach e-learning training platform, assessing coach learning outcomes (ie, knowledge and behavior), and estimating the cost and viability of implementing this training.
Patient Satisfaction With a Coach-Guided, Technology-Based Mental Health Treatment: Qualitative Interview Study and Theme Analysis (Preprint)
Authors: Smith Ashley Helm , Touchett Hilary , Chen Patricia , Fletcher Terri , Arney Jennifer , Hogan Julianna , Wassef Miryam , Cloitre Marylene , Lindsay Jan A
Published: July 2023

BACKGROUND

Technology-based mental health interventions address barriers rural veterans face in accessing care, including provider scarcity and distance from the hospital or clinic. webSTAIR is a 10-module, web-based treatment based on Skills Training in Affective and Interpersonal Regulation, designed to treat posttraumatic stress disorder and depression in individuals exposed to trauma. Previous work has demonstrated that webSTAIR is acceptable to participants and effective at reducing symptoms of posttraumatic stress disorder and depression when delivered synchronously or asynchronously (over 5 or 10 sessions).

OBJECTIVE

This study explored factors that lead to greater patient satisfaction with webSTAIR, a web-based, coach-guided intervention.

METHODS

We analyzed qualitative interview data to identify themes related to patient satisfaction with webSTAIR delivered with synchronous video-based coaching.

RESULTS

Four themes emerged from the data: (1) coaching provides accountability and support, (2) self-pacing offers value that meets individual needs, (3) participants like the comfort and convenience of the web-based format, and (4) technical issues were common but not insurmountable.

CONCLUSIONS

We conclude that participants valued the accountability, flexibility, and convenience of tech-based interventions with video-delivered coaching.
Kepemimpinan Kepala Desa dan Pengawasan Masyarakat dalam Mewujudkan Akuntabilitas Pengelolaan Dana Desa
Authors: Nandyasa Vania Sarinastiti  , Bhilawa Loggar
Published: July 2023

Purpose: The leadership of the village head is a major part of managing village funds, but there are still many cases of misuse of village funds by village government officials, especially the village head, besides that the lack of oversight from the community has led to rampant cases of corruption in village funds within the village administration. The patriarchal culture places men as the main power holders who are still dominant in Indonesia. Not many women are currently leaders. This study aims to determine the influence of the village head's leadership and community supervision on the accountability of managing village funds with masculinity as a moderating variable.
Methodology/Approach: This research is a quantitative research with primary data sources in the form of questionnaires distributed to the people of Batangsaren Village, Tulungagung Regency. Data analysis technique using multiple linear regression through the SPSS program.
Findings: Based on the research results, researchers can conclude that the village head's leadership and community oversight have an effect on the accountability of managing village funds.
Practical and Theoretical contribution/Originality: Masculinity does not moderate the influence of village head leadership on village fund management accountability and masculinity moderates the influence of community oversight on village fund management accountability.
PENGARUH FIRM SIZE, LEVERAGE, SALES GROWTH, DAN PROFITABILITAS TERHADAP FINANCIAL DISTRESS (STUDI EMPIRIS PADA PERUSAHAAN SEKTOR PROPERTY DAN REAL ESTATE YANG TERDAFTAR DI BEI TAHUN 2015-2019)
Authors: Hakim Rahman , Wiralestari Wiralestari , Yetti Susfa
Published: July 2023

Penelitian ini bertujuan untuk menguji pengaruh Ukuran Perusahaan, Leverage, Pertumbuhan Penjualan dan Profitabilitas terhadap Kesulitan Keuangan. Sampel yang digunakan dalam penelitian ini adalah perusahaan Properti dan Real Estate yang terdaftar di BEI periode 2015-2019. Pengambilan sampel menggunakan purposive sampling dan diperoleh sebanyak 31 perusahaan dalam penelitian ini, sebanyak 155 data. Pengujian hipotesis dilakukan dengan analisis regresi logistik menggunakan software SPSS 26.0. Hasil penelitian menunjukkan bahwa Ukuran Perusahaan, Leverage, Pertumbuhan Penjualan dan Profitabilitas secara simultan berpengaruh terhadap Financial Distress. Leverage dan profitabilitas secara parsial mempengaruhi financial distress. Sedangkan Firm Size dan Sales Growth secara parsial tidak berpengaruh terhadap financial distress.
Relação entre iniquidade racial e violência obstétrica no parto
Authors: Alves Guilherme , Lopes Renata Silva , Cabral Joyce Nunes , Moreira Ana Paula Assunção , Cecílio Jessica Oliveira , Batista Amanda Santos Fernandes Coelho
Published: July 2023

Introdução: A iniquidade racial é a desigualdade em oportunidades e condições devida que acontece em decorrência da etnia de uma pessoa. Indivíduos pretos, pardos e indígenas são modelos de povos que resistem aos desafios subsequentes dos processos históricos de segregação. Objetivo: Verificar a influência dos aspectos raciais na prática de violência obstétrica na atenção ao parto e nascimento. Métodos: Trata-se de um estudo com abordagem quantitativa, de corte transversal, com coleta de dados prospectiva, realizado em uma maternidade pública na cidade de Goiânia, Goiás. Resultados: Pode-se determinar um cuidado menos satisfatórios para as mulheres negras quando comparado com as brancas para a maioria dos indicadores avaliados neste estudo. Mulheres pretas e pardas têm maior chance de sofrerem manobra de Kristeller, amniotomia precoce, privação alimentar no trabalho de parto, clampeamento imediato do cordão umbilical e menor chance de contato pele a pele e de ser ofertado métodos não farmacológicos para o alívio da dor. Conclusão: O fator raça/cor influencia no tratamento em que as mulheres recebem dentro do estabelecimento de saúde.
INFLUENCE OF ONLINE CUSTOMER REVIEW AND ONLINE CUSTOMER RATING ON GOFOOD PURCHASE DECISIONS IN THE GOJEK APPLICATION
Authors: Lila Febriana Kausaha  , Ida Hidayanti  , Ririn Damayanti
Published: July 2023

This study aims to determine the effect of the dependent and independent variables partially and simultaneously. The research methodology used a quantitative method by collecting data through distributing questionnaires, the population in this study were users of the Gojek application in Ternate City, the sampling technique used purposive sampling and snowball sampling with 125 respondents. Data were obtained by using multiple linear regression analysis with the SPSS 25 program. The results indicate that partially online customer reviews have a significant effect on purchasing decisions for GoFood on the Gojek application, while online customer ratings partially have no significant effect on purchasing decisions for GoFood on the Gojek application, and simultaneously or together online customer reviews and online customer ratings have an effect significantly to GoFood purchasing decisions on the Gojek application.
Prenatal diagnosis of an adrenal mature teratoma mimicking a neuroblastoma
Authors:   Pediatric Surgery Department, Children’s Hospital of Toulouse, CHU Toulouse, Toulouse, France, Garcia Camille , Fusi Giulia ,   "Division of Pediatric Surgery, Department of Medical Sciences, Surgical Sciences and Neurosciences, Hospital of ‘‘Santa Maria Alle Scotte’’, Siena, Italy", Gambart Marion ,   "Department of Pediatric Oncology, Children’s Hospital of Toulouse, CHU Toulouse, Toulouse, France"
Published: July 2023

Teratomas are defined by the presence of cell types from different germ layers, they typically involve the gonads or the sacrococcygeal region and are rarely retroperitoneal. Prenatally detected adrenal teratomas are extremely uncommon. Aim of this paper is to share our experience with an adrenal antenatal mass initially diagnosed as a left adrenal neuroblastoma that turned out to be a mature teratoma after microscopical examination. We present the case of a male fetus with antenatal diagnosis of a left adrenal cystic image at the 22nd weeks of amenorrhea. The fetal magnetic resonance imaging showed a non-calcified cystic mass of the left adrenal gland, compatible with a neuroblastoma. At birth an ultrasound confirmed the presence of an anechogenic lesion of the left adrenal gland. The infant was closely monitored during his first year and in the absence of significant regression of the adrenal mass, it was decided to perform a laparoscopic left adrenalectomy. Unexpectedly, the final pathological diagnosis was mature cystic adrenal teratoma. In conclusion, an adrenal mass diagnosed antenatally is generally a hemorrhage or a neuroblastoma. Adrenal teratomas are very rare and those diagnosed antenatally even more. At present, we have no clinical, biological, or radiological evidence to suspect them before surgical removal. There are only two other cases of unexpected adrenal teratoma in infants described in Literature.
Perceived Teaching Creativity and Strategy of Implementation in Distance Learning Activities
Authors: Widiningsih Made Adrina , Artini Luh Putu , Utami Ida Ayu Made Istri
Published: July 2023

Distance learning has been implemented in many schools due to covid-19. But it is still unknown whether teachers integrate creativity in learning still needs to be investigated. Therefore the aims of this study are to analyze how the teachers perceived their own creativity in teaching in the classroom. Then how they implanted in distance learning and analyze there is the discrepancy occurred between how the teachers’ perception toward their creativity and the facts of how the teachers implemented their creativity in the real teaching. Mix method was employed as the design of this study which meant there were primary and supportive data. The qualitative data was dominant than quantitative data. The setting of this study was in senior high school and two English teachers selected as the subject of this study. Self-rated questionnaire and classroom observation sheet were used as the instruments. The result of study showed that the teachers perceived themselves as creative, however, the teachers’ creativity was classified in slightly creative based on the observation. Those data demonstrated that there was the discrepancy between the teachers’ perception toward their creativity in the class. The implication of this research is the creativity in distance learning requires more than teachers' willingness, it also requires students' financial support.
Antecedentes da intenção de adoção de Fintechs no Brasil
Authors: Carvalho Gabriel Coimbra , Bastos Sérgio Augusto Pereira
Published: July 2023

O objetivo foi investigar os antecedentes da intenção de adoção dos serviços de Fintechs no Brasil. Considerando o pressuposto de aceitação ao risco pelos clientes, o modelo teórico indicou as relações entre confiança, benefício percebido e intenção dos clientes. Os dados, coletados por survey, foram analisados por modelo de equações estruturais. Os resultados indicaram que a confiança e a benefício percebido influenciam positivamente a intenção de adoção dos serviços de Fintechs e que há uma relação de mediação parcial da confiança na relação de benefício percebido e intenção. Assim, embora haja um mercado em ainda a ser explorado para as empresas desse setor, os resultados indicam que a confiança é fator relevante na equação expansão dos serviços das Fintechs.
Farklı Orman Ağaç Türleri Altındaki Toprak Özelliklerinin ve Besin Stoklarının Yükselti, Bakı ve Toprak Derinliğine Göre Değişimi
Authors: SARIYILDIZ Temel , SAVACI Gamze
Published: July 2023

Çalışma toprak makro (C, N, P, K, Ca, Mg) ve mikro (Fe, Mn, Na, Cu, Zn, Al) besin stoklarına, yükselti, bakı ve ağaç türlerinin etkisini araştırmak için Kastamonu ili Daday ilçesi ormanlarında gerçekleştirilmiştir. Çalışmada, dört ağaç türünde (sarıçam, karaçam, kayın ve meşe) ve üç toprak derinliğinden (0-10, 10-20, 20-30 cm) olmak üzere iki bakı (güneşli ve gölgeli) ve iki yükselti basamağında (1189 m ve 871 m) örnek alanlar seçilmiştir. Sonuçlara göre, türler arasında en yüksek C (57.7 ton/ha), N (3.32 ton/ha) ve P (0.181 ton/ha) stoku kayın, en düşük meşede (39.7-ton C ha-1; 2.37-ton N ha-1, 0.115-ton P ha-1) bulunmuştur. Ağaç türleri arasında ortalama değerlere göre en yüksek kalsiyum stoku karaçamda (3.64 ton/ha) ve meşede (2.41 ton/ha), en düşük sarıçam (0.73 ton/ha) ve kayında (0.67 ton/ha) tespit edilirken, en yüksek potasyum stoku sarıçamda (3.60 ton/ha), sonrasında kayında (2.92 ton/ha), karaçamda (2.16 ton/ha) ve en düşük meşede (1.03 ton/ha) tespit edilmiştir. Makro besin stoklarının yükselti ile bakıya bağlı olarak önemli değişiklik gösterdiği, fakat değişikliğin yönünün ağaç türü ve besin elementine göre farklılık gösterdiği belirlenmiştir. Mikro besin stoklarında farklılıklar genel olarak aynı yönde değişim göstermiştir. Mikro besin stokları üst rakım ve güneşli bakılarda daha yüksek, türler arasında ise sarıçam ve kayında, karaçam ve meşeden daha fazla bulunmuştur.
The Comparing of Problem-Based Learning and Lecture-Based Learning on Students’ Learning Outcomes and Satisfaction for a Family Health Nursing Course
Authors: Susanto Tantut , Rasni Hanny , Susumaningrum Latifa Aini , Adi Yunanto Rismawan
Published: July 2023

Background: Problem - Based Learning (PBL) is a method of student-centered learning. In PBL, students become centered to the learning process, whereas the teacher is the center of learning in lecture-based learning (LBL). Purpose: This study aimed to compare the effects of PBL and LBL on students’ learning outcomes and satisfaction on an undergraduate nursing course. Methods: Quasi-experimental study. Participants included 161 students from two different classes of the course; in 2013, as a control group (n = 88) and in 2014 as an intervention group (n = 73). Both groups received LBL, which is practice in the lab and clinic, but the intervention group also received PBL. Secondary data analysis of students’ learning outcomes was measured using students’ learning progress in tests from lecture (theory, paper, laboratory, and clinical), while students’ satisfaction was measured using teaching method evaluation from students. Results: Students’ learning outcomes (theory, laboratory, and clinical) in the PBL group were significantly more than in the control group (p<0.001), whereas paper lesson outcomes were higher in control group compared to the intervention group (t=6.43; p<0.001; 95% CI=1.46-2.76). There was more satisfaction with the PBL method. There was no relationship between students’ satisfaction and learning outcomes (p>0.05). However, students considered greater satisfaction in PBL compared to LBL. Conclusions: In problem-based learning, students contributed a lot to solving the problem and getting the skills and knowledge they needed. Students are also expected to be motivated.
Refusal Expression in L2 and its Comparison with Native Speaker: A Study Case in the Japanese Language
Authors: Nurjaleka Lisda
Published: July 2023

This study aims to fill the gap of the comparison study between Japanese learners and native Japanese speakers, focused on the semantic formula of refusal act. Sixteen Japanese native speakers and twenty-two Indonesian learners are the subjects of this study. We use a questionnaire or Discourse Completion Test (DCT) to collect the data, and we use the semantic formula by Ito and Ikeda to analyze the refusal utterances. This paper reveals that Indonesian Japanese learners tended to not aware of different social status levels and use different semantic formulas in Japanese. The lack of knowledge of the pragmatic competence within the use of speech act is the main problem in Japanese education.
Maxims of Politeness Performed by Female Sellers at Traditional Market in Sumatera Barat
Authors: Revita Ike , Marwati Sofia , Ayumi Ayumi , Mardiah Ainun
Published: July 2023

This research is aimed at describing the maxims of politeness used by female sellers in a traditional market in Sumatera Barat. The research was conducted in one tradititonal market in Sumatera Barat, namely Batu Sangkar. The data are any utterances produced by female sellers in a traditional market in a traditional market in Batu Sangkar. The data were taken by the observational method with note-taking, recording, and interviewing techniques. The analysis was done by using the concept proposed by (Oktavianus & Revita, 2013; Leech, 1983). The result of the analysis was descriptively done and used the chart. The percentage was also used to identify the number of maxims that occurred. Having analyzed the data, it is found that the female sellers used four maxims in their interaction with the buyers. They are 1) tact, 2) agreement, and 3)modesty. There are two types of agreement between the sellers and the buyers, namely using 1) verbal and 2) non-verbal agreement. The non-verbal agreement is the indication of the insincerity of the sellers of the price bargained by the buyers. The sellers do not get much profit from the price offered by the buyers.