bluuebunny/crossref_metadata_2025 huggingface dataset:
A phase 1 trial of vadastuximab talirine as monotherapy in patients with CD33-positive acute myeloid leukemia
Authors: Stein Eytan M. , Walter Roland B. , Erba Harry P. , Fathi Amir T. , Advani Anjali S. , Lancet Jeffrey E. , Ravandi Farhad , Kovacsovics Tibor , DeAngelo Daniel J. , Bixby Dale , Faderl Stefan , Jillella Anand P. , Ho Phoenix A. , O’Meara Megan M. , Zhao Baiteng , Biddle-Snead Charles , Stein Anthony S.
Published: December 2017

Key Points

Vadastuximab talirine, a novel antibody-drug conjugate, consists of an anti-CD33 monoclonal antibody conjugated to pyrrolobenzodiazepine dimers. In a phase 1 trial, vadastuximab talirine demonstrated single-agent activity and minimal nonhematologic toxicity in patients with AML.
Expression of TP53 is associated with the outcome of MCL independent of MIPI and Ki-67 in trials of the European MCL Network
Authors: Aukema Sietse M. , Hoster Eva , Rosenwald Andreas , Canoni Danielle , Delfau-Larue Marie-Hélène , Rymkiewicz Grzegorz , Thorns Christoph , Hartmann Sylvia , Kluin-Nelemans Hanneke , Hermine Olivier , Dreyling Martin , Klapper Wolfram
Published: December 2017

Key Points

TP53 expression (>50% positive cells) has shorter TTF and poor OS independent of both MIPI score and Ki67 index.
European Respiratory Society statement: diagnosis and treatment of pulmonary disease in α1-antitrypsin deficiency
Authors: Miravitlles Marc , Dirksen Asger , Ferrarotti Ilaria , Koblizek Vladimir , Lange Peter , Mahadeva Ravi , McElvaney Noel G. , Parr David , Piitulainen Eeva , Roche Nicolas , Stolk Jan , Thabut Gabriel , Turner Alice , Vogelmeier Claus , Stockley Robert A.
Published: December 2017

α1-antitrypsin deficiency (AATD) is the most common hereditary disorder in adults. It is associated with an increased risk of developing pulmonary emphysema and liver disease. The pulmonary emphysema in AATD is strongly linked to smoking, but even a proportion of never-smokers develop progressive lung disease. A large proportion of individuals affected remain undiagnosed and therefore without access to appropriate care and treatment.

The most recent international statement on AATD was published by the American Thoracic Society and the European Respiratory Society in 2003. Since then there has been a continuous development of novel, more accurate and less expensive genetic diagnostic methods. Furthermore, new outcome parameters have been developed and validated for use in clinical trials and a new series of observational and randomised clinical trials have provided more evidence concerning the efficacy and safety of augmentation therapy, the only specific treatment available for the pulmonary disease associated with AATD.

As AATD is a rare disease, it is crucial to organise national and international registries and collect information prospectively about the natural history of the disease. Management of AATD patients must be supervised by national or regional expert centres and inequalities in access to therapies across Europe should be addressed.
How to evaluate the immune status of lung cancer patients before immunotherapy
Authors: Domagala-Kulawik Joanna , Raniszewska Agata
Published: December 2017

Nowadays, cancer immunotherapy is a promising strategy in solid tumour treatment. It has become a breakthrough in achieving long-term survival in many advanced cases. The essence of modern immunotherapy is to improve the host antitumour immune defence. Currently, it is critically important to determine the biomarkers that could be helpful in planning this type of individual therapy. It has turned out that an important prognostic factor is the evaluation of inflammatory infiltration of the tumour mass, including the characteristics of populations of lymphocytes and macrophages, and the expression of suppressive and regulatory molecules. For lung cancer, <30% of the tumours are resectable and available for a complete microscopic examination. In other cases, the material for the study of inflammatory infiltration may be a tumour biopsy, but this is of limited importance. A valuable way to evaluate the microenvironment of tumour growth is a bronchoalveolar lavage (BAL) fluid examination. In the BAL fluid, the cellular and noncellular components determine the specific type of inflammatory response in an environment of developing cancer. BAL fluid analysis may be a valuable addition to peripheral blood analysis during qualification for modern immunomodulatory therapy. Moreover, it is important material to seek biomarkers of clinical significance.
The physiological effects of slow breathing in the healthy human
Authors: Russo Marc A. , Santarelli Danielle M. , O’Rourke Dean
Published: December 2017

Slow breathing practices have been adopted in the modern world across the globe due to their claimed health benefits. This has piqued the interest of researchers and clinicians who have initiated investigations into the physiological (and psychological) effects of slow breathing techniques and attempted to uncover the underlying mechanisms. The aim of this article is to provide a comprehensive overview of normal respiratory physiology and the documented physiological effects of slow breathing techniques according to research in healthy humans. The review focuses on the physiological implications to the respiratory, cardiovascular, cardiorespiratory and autonomic nervous systems, with particular focus on diaphragm activity, ventilation efficiency, haemodynamics, heart rate variability, cardiorespiratory coupling, respiratory sinus arrhythmia and sympathovagal balance. The review ends with a brief discussion of the potential clinical implications of slow breathing techniques. This is a topic that warrants further research, understanding and discussion.

Key points

Slow breathing practices have gained popularity in the western world due to their claimed health benefits, yet remain relatively untouched by the medical community.

Investigations into the physiological effects of slow breathing have uncovered significant effects on the respiratory, cardiovascular, cardiorespiratory and autonomic nervous systems.

Key findings include effects on respiratory muscle activity, ventilation efficiency, chemoreflex and baroreflex sensitivity, heart rate variability, blood flow dynamics, respiratory sinus arrhythmia, cardiorespiratory coupling, and sympathovagal balance.

There appears to be potential for use of controlled slow breathing techniques as a means of optimising physiological parameters that appear to be associated with health and longevity, and that may extend to disease states; however, there is a dire need for further research into the area.

Educational aims

To provide a comprehensive overview of normal human respiratory physiology and the documented effects of slow breathing in healthy humans.

To review and discuss the evidence and hypotheses regarding the mechanisms underlying slow breathing physiological effects in humans.

To provide a definition of slow breathing and what may constitute “autonomically optimised respiration”.

To open discussion on the potential clinical implications of slow breathing techniques and the need for further research.
The potential of palliative care for patients with respiratory diseases
Authors: Narsavage Georgia L. , Chen Yea-Jyh , Korn Bettina , Elk Ronit
Published: December 2017

Based on the demonstrated effectiveness of palliative care in the alleviation of symptoms and enhancement of life quality, it is important to incorporate palliative care early in the respiratory disease trajectory. Quality palliative care addresses eight domains that are all patient and family centred. Palliative care interventions in respiratory conditions include management of symptoms such as dyspnoea, cough, haemoptysis, sputum production, fatigue and respiratory secretion management, especially as the end-of-life nears. A practical checklist of activities based on the domains of palliative care can assist clinicians to integrate palliative care into their practice. Clinical management of patients receiving palliative care requires consideration of human factors and related organisational characteristics that involve cultural, educational and motivational aspects of the patient/family and clinicians.

Educational aims

To explain the basic domains of palliative care applicable to chronic respiratory diseases.

To review palliative care interventions for patients with chronic respiratory diseases.

To outline a checklist for clinicians to use in practice, based on the domains of palliative care.

To propose recommendations for clinical management of patients receiving palliative care for chronic respiratory diseases.
Systematic review into factors associated with the recruitment crisis in psychiatry in the UK: students', trainees' and consultants' views
Authors: Choudry Abid , Farooq Saeed
Published: December 2017

Aims and method

To review the literature to examine the factors that may be affecting recruitment into psychiatry in the UK. We systematically searched four databases to identify studies from 1974 to 2016 and identified 27 papers that met the specified inclusion criteria.

Results

Most papers (n= 24) were based on questionnaire surveys. The population in all studies comprised of 1879 psychiatrists, 6733 students and 220746 trainees. About 4–7% of students opt for a career in psychiatry. Enrichment activities helped to attract students more towards psychiatry than just total time spent in the specialty. Job content in terms of the lack of scientific basis, poor prognosis and stigma towards psychiatry, work-related stress and problems with training jobs were common barriers highlighted among students and trainees, affecting recruitment. Job satisfaction and family-friendly status of psychiatry was rated highly by students, with lifestyle factors appearing to be important for trainees who tend to choose psychiatry.

Clinical implications

Negative attitudes and stigma towards psychiatry continue to persist. Teaching and training in psychiatry needs rethinking to improve student experience and recruitment into the specialty.
National survey of training of psychiatrists on advance directives to refuse treatment in bipolar disorder
Authors: Morriss Richard , Mudigonda Mohan , Bartlett Peter , Chopra Arun , Jones Steven
Published: December 2017

Aims and method

To determine features associated with better perceived quality of training for psychiatrists on advance decision-making in the Mental Capacity Act 2005 (MCA), and whether the quality or amount of training were associated with positive attitudes or use of advance decisions to refuse treatment (ADRTs) by psychiatrists in people with bipolar disorder. An anonymised national survey of 650 trainee and consultant psychiatrists in England and Wales was performed.

Results

Good or better quality of training was associated with use of case summaries, role-play, ADRTs, assessment of mental capacity and its fluctuation. Good or better quality and two or more sessions of MCA training were associated with more positive attitudes and reported use of ADRTs, although many psychiatrists would never discuss them clinically with people with bipolar disorder.

Clinical implications

Consistent delivery of better-quality training is required for all psychiatrists to increase use of ADRTs in people with bipolar disorder.
Measuring relational security in forensic mental health services
Authors: Chester Verity , Alexander Regi T. , Morgan Wendy
Published: December 2017

Aims and method

Relational security is an important component of care and risk assessment in mental health services, but the utility of available measures remains under-researched. This study analysed the psychometric properties of two relational security tools, the See Think Act (STA) scale and the Relational Security Explorer (RSE).

Results

The STA scale had good internal consistency and could highlight differences between occupational groups, whereas the RSE did not perform well as a psychometric measure.

Clinical implications

The measures provide unique and complimentary perspectives on the quality of relational security within secure services, but have some limitations. Use of the RSE should be restricted to its intended purpose; to guide team discussions about relational security, and services should refrain from collecting and aggregating this data. Until further research validates their use, relational security measurement should be multidimensional and form part of a wider process of service quality assessment.
Cardiac Arrest in the Operating Room: Part 2—Special Situations in the Perioperative Period
Authors: McEvoy Matthew D. , Thies Karl-Christian , Einav Sharon , Ruetzler Kurt , Moitra Vivek K. , Nunnally Mark E. , Banerjee Arna , Weinberg Guy , Gabrielli Andrea , Maccioli Gerald A. , Dobson Gregory , O’Connor Michael F.
Published: December 2017

As noted in part 1 of this series, periprocedural cardiac arrest (PPCA) can differ greatly in etiology and treatment from what is described by the American Heart Association advanced cardiac life support algorithms, which were largely developed for use in out-of-hospital cardiac arrest and in-hospital cardiac arrest outside of the perioperative space. Specifically, there are several life-threatening causes of PPCA of which the management should be within the skill set of all anesthesiologists. However, previous research has demonstrated that continued review and training in the management of these scenarios is greatly needed and is also associated with improved delivery of care and outcomes during PPCA. There is a growing body of literature describing the incidence, causes, treatment, and outcomes of common causes of PPCA (eg, malignant hyperthermia, massive trauma, and local anesthetic systemic toxicity) and the need for a better awareness of these topics within the anesthesiology community at large. As noted in part 1 of this series, these events are always witnessed by a member of the perioperative team, frequently anticipated, and involve rescuer–providers with knowledge of the patient and the procedure they are undergoing or have had. Formulation of an appropriate differential diagnosis and rapid application of targeted interventions are critical for good patient outcome. Resuscitation algorithms that include the evaluation and management of common causes leading to cardiac in the perioperative setting are presented. Practicing anesthesiologists need a working knowledge of these algorithms to maximize good outcomes.
Randomized Clinical Trial of Preoperative High-Dose Methylprednisolone on Postoperative Pain at Rest After Laparoscopic Appendectomy
Authors: Kleif Jakob , Hauge Camilla I. , Vilandt Jesper , Gögenur Ismail
Published: December 2017

BACKGROUND:

Methylprednisolone administered intravenously preoperatively has been shown to reduce pain, nausea, and fatigue after elective surgery. We aimed to show that 125 mg of methylprednisolone given intravenously 30 minutes before laparoscopic surgery for suspected appendicitis would reduce pain at rest during the first 3 postoperative days.

METHODS:

A multicenter, parallel-group, double-blind, placebo-controlled study was conducted including patients 18 years of age and older with an American Society of Anesthesiologist class of I–III undergoing laparoscopic surgery for suspected appendicitis. The primary outcome was pain at rest measured on the 11-point numerical rating scale 5 times during the first 3 days after surgery. The effect of 125 mg of methylprednisolone on postoperative pain at rest during the first 3 days was assessed using a mixed-effects model with time and intervention as main effects.

RESULTS:

From April 2016 to August 2016, 78 patients were included, and all were eligible for analysis of the primary outcome. The estimated effect of 125 mg of methylprednisolone on pain at rest during the first 3 days after surgery was a nonsignificant increase of 0.2 (95% confidence interval, −0.5 to 0.9; P = .571) on the 11-point numerical rating scale. There was no difference between the 2 groups regarding the need for opioid agonists during hospital stay on the first postoperative day (P = .381).

CONCLUSIONS:

A 125-mg dose of methylprednisolone given intravenously 30 minutes before laparoscopic surgery for appendicitis seemed no better than placebo at providing a clinical meaningful reduction in postoperative pain at rest.
High-content tripartite split-GFP cell-based assays to screen for modulators of small GTPase activation
Authors: Koraïchi Faten , Gence Rémi , Bouchenot Catherine , Grosjean Sarah , Lajoie-Mazenc Isabelle , Favre Gilles , Cabantous Stéphanie
Published: December 2017

The human Ras superfamily of small GTPases controls essential cellular processes such as gene expression and cell proliferation. As their deregulation is widely associated with human cancer, small GTPases and their regulatory proteins have become increasingly attractive for the development of novel therapeutics. Classical methods to monitor GTPase activation include pulldown assays that limit the analysis of GTP-bound form of proteins from cell lysates. Alternatively, live-cell FRET biosensors may be used to study GTPase activation dynamics in response to stimuli, but these sensors often require further optimization for high-throughput applications. Here, we describe a cell-based approach that is suitable to monitor the modulation of small GTPase activity in a high-content analysis. The assay relies on a genetically encoded tripartite split-GFP (triSFP) system that we integrated in an optimized cellular model to monitor modulation of RhoA and RhoB GTPases. Our results indicate the robust response of the reporter, allowing the interrogation of inhibition and stimulation of Rho activity, and highlight potential applications of this method to discover novel modulators and regulators of small GTPases and related protein-binding domains.
Hormesis-like effect of mild larval crowding on thermotolerance inDrosophilaflies
Authors: Youn Henry , David Renault , Hervé Colinet
Published: December 2017

Crowding is a complex stress that can affect organisms’ physiology, especially through decreased food quality and accessibility. Here, we evaluated the effect of larval density on several biological traits of Drosophila melanogaster. An increasing gradient, from 1 to 1000 eggs per milliliter of food, was used to characterize life-history traits variations. Crowded conditions resulted in striking decreases of fresh mass (up to six-fold) and viability, as well as delayed development. Next, we assessed heat and cold tolerance in L3 larvae reared at three selected larval densities: low (LD, 5 eggs.mL−1), medium (MD, 60 eggs.mL−1) and high (HD, 300 eggs.mL−1). LT50 values of MD and, to a lesser extent, HD larvae were repeatedly higher than those from LD larvae, under both heat and cold stress. We investigated potential physiological correlates associated with this density-dependent thermotolerance shift. No marked pattern could be drawn from the expression of stress-related genes. However, a metabolomic analysis differentiated the metabotypes of the three density levels, with potential candidates associated with this clustering (e.g. glucose 6 phosphate, GABA, sugars and polyols). Under HD, signs of oxidative stress were noted but not confirmed at the transcriptional level. Finally, urea, a common metabolic waste, was found to accumulate substantially in food from MD and HD. When supplemented in food, urea stimulated cold tolerance but reduced heat tolerance in LD larvae. This study highlights that larval crowding is an important environmental parameter that induces drastic consequences on flies’ physiology and can affect thermotolerance in a density specific way.
Determining forward speed from accelerometer jiggle in aquatic environments
Authors: Cade David E. , Barr Kelly R. , Calambokidis John , Friedlaender Ari S. , Goldbogen Jeremy A.
Published: December 2017

How fast animals move is critical to understanding their energetic requirements, locomotor capacity, and foraging performance, yet current methods for measuring speed via animal-attached devices are not universally applicable. Here we present and evaluate a new method that relates forward speed to the stochastic motion of biologging devices since tag jiggle, the amplitude of the tag vibrations as measured by high sample rate accelerometers, increases exponentially with increasing speed. We successfully tested this method in a flow tank using two types of biologging devices and tested the method in situ on wild cetaceans spanning ∼3 to >20 m in length using two types of suction cup-attached and two types of dart-attached tag. This technique provides some advantages over other approaches for determining speed as it is device-orientation independent and relies only on a pressure sensor and a high sample rate accelerometer, sensors that are nearly universal across biologging device types.
ΚΩΣΤΑΣ ΔΟΥΖΙΝΑΣ - RONNIE WARRINGTON, Ο Λόγος του Νόμου, εκδ. Αλεξάνδρεια, Αθήνα 1994, και Justice Miscarried, εκδ. Harvester Wheatsheaf, Λονδίνο 1994.
Authors: Αριστοδήμου Μαρία
Published: December 2017

[Δεν διατίθεται περίληψη / no abstract available]
Εναλλακτικά κοινωνικά κινήματα: Η αναζήτηση του εφικτού ανάμεσα σε υποκειμενικές ανάγκες και κρατικές πολιτικές
Authors: Ψημίτης Μιχάλης
Published: December 2017

Δεν διατίθεται περίληψη στα ελληνικά
Names of Assam tea: Their priority, typification and nomenclatural notes
Authors: Zhao Dongwei , Parnell John A.N. , Hodkinson Trevor R.
Published: December 2017

Various names have been used for Assam tea and they are typified here. The currently widely used name, Camellia sinensis var. assamica, is a combination based on Thea viridis var. assamica, not “T. assamica” because the latter was never validly published. Two earlier published names, C. theifera and T. cochinchinensis, and two later ones, C. tenuistipa and T. yersinii, may represent the same taxon and are treated as synonyms of T. viridis var. assamica because the latter has priority at the rank of variety and therefore is the correct name for Assam tea.
Use of statistical tools to assess the quality of education
Authors: Овчинникова Ираида , Ovchinnikova Iraida , Курзаева Любовь , Kurzaeva Lyubov
Published: December 2017

The article discusses the problems associated with the management of the quality of education, it is shown that quality management education is impossible without reliance on proven statistical tools. The authors analyze the characteristics of quality management education and show that an integral element of the management of this process is the correct setting goals, having the operational and prediction properties in the zone of potential development of the student. The authors identify and justify the need for the provision of a system of indicators that allow determining the degree of achievement of objectives in the educational system. They analyze the classification of indicators from the point of view of education quality assessment identified a normative and comparative nature of the assessment indicators, the role and place of statistics in the evaluation of the quality of the educational process. Based on the conducted research the authors propose the method of using this statistical tool, as Shewhart charts, and to assess the implementation of the educational process and/or results and decision on the need for corrective actions. The article gives the definition of Shewhart charts, and describes the purpose of this instrument, marked the boundaries of its application, the analysis of varieties of charts, with the main features and the estimated values, the technique of their construction. Particular value is an example of using Shewhart charts to assess the quality of student performance, which demonstrates the role of this statistical tool in deciding the stability of the educational process or the need for corrective actions, i.e. external intervention in the process. The article may be interesting for practitioners in the course of training courses on the subject and in the process of improving quality management systems in educational institutions.
The formation of USA Legal System: main structural elements and dynamics of development
Authors: Саломатин Алексей , Salomatin Alexey
Published: December 2017

The article deals with the evolution of USA Legal System starting from the 1787 Constitution till the end of the 19th century. Taking corporate, land regulation, criminal law as examples the author considers participation of federal and state powers in solving actual legal problems. It is demonstrated that in spite of broad legal rights of states from the very beginning they were not able to decide themselves burning issues of social and economic life without interference of Federal Government. And Federal Government was clever enough to build up a strong federal court system in the early years of the Republic. This system not only furthered some kind of uniformity of law under grass roots federalism but safequarded American federalism itself. Thanks to broad interpretative powers of US Supreme Court which decided what was Constitutional or non-Constitutional in state and federal legislation American civilization not only has preserved itself from dangers of separatism but achieved great paces of development.
Sources (forms) of law: comparative and histor ical analysis
Authors: Минникес Ирина , Minnikes Irina
Published: December 2017

The article examines a wide range of sources of law of different law families on the different stages of development of law and state. Several types of classification of law sources are found - by value and role of the source in law system, by its external appearance, by order of enactment and registration of the change in its content. By the role in law system several gradations of sources are discovered: main and additional, dominant and auxiliary. By appearance sources can be divided to written and unwritten, formal and informal, structured and unstructured. By order of enactment and registration of the changes sources can be divided to consensus, unilateral and sanctioned, sole, collegial and mixed, as well as flexible and rigid.
Modern Pedagogical Technologies As a Tool of Modeling of Professional Activity in Educational Process of Pedagogical College
Authors: Сморчкова В. , Smorchkova V. , Сумнительный К. , Sumnitel'nyy K.
Published: December 2017

In article the urgency of development of modern educational technologies by teachers of pedagogical colleges is justifi ed. Relevance is considered as part of the philosophy of education, and in the context of legislative changes enshrined in the law “On education in the Russian Federation” and the FSES at all levels. We considered two aspects of this process: educational technology used in teaching, and support of college students in the selection of complex educational technologies to replenish professional tools for future teachers. The factors which prevent not only the process of implementation of pedagogical technologies in educational process of pedagogical colleges, but also in the practice of General education are considered. The measures to facilitate the organization of such a process are off ered and criteria that can be used both for the selection of the most eff ective for teaching in a teacher training college, and for the creation by future teachers of their own complex of pedagogical technologies are given.
Course design for engineering technology
Authors: Шрубченко Иван , Shrubchenko Ivan , Погонин Анатолий , Pogonin Anatoliy , Афанасьев Александр , Afanas'ev Aleksandr
Published: December 2017

The theme of design is the tech-nological process of manufac-turing a part or article, a tech-nological process of assembly or elements of both. Course design is the basis for independent work of the student when solv-ing a complex set of technologi-cal issues in the conditions of production and systematization and deepening of knowledge in general technical and special disciplines. It includes a compu-tational and explanatory note (PZ) with a full set of issues re-lated to technological design, with a concise, clear and techni-cally sound justification for all technical decisions taken in the project: the technological route of the workpiece, the technolo-gical setup of equipment or the RTC for CNC machines , tech-nological scheme of assembly of the product; operational tech-nological schemes of assembly.
Prevalence of Dysphagia in People With Intellectual Disability: A Systematic Review
Authors: Robertson Janet , Chadwick Darren , Baines Susannah , Emerson Eric , Hatton Chris
Published: December 2017

Dysphagia (feeding and swallowing disorder) is associated with serious health complications and psychosocial sequelae. This review summarizes international research relating to the prevalence of dysphagia in people with intellectual disability. Studies published from 1990 to July 2016 were identified using Medline, Cinahl, PsycINFO, Web of Science, email requests, and cross-citations. Twenty studies were identified. Dysphagia in people with intellectual disability appears to be associated with more severe levels of intellectual disability, comorbid cerebral palsy, and motor impairments. However, further research with representative samples of people with intellectual disability using adequate methods of assessment are required in order to provide more precise prevalence estimates and clarify factors that may be associated with dysphagia in this population.
Epigrafía de Carthago Nova (Cartagena, España): aportaciones metodológicas al estudio técnico y espacial
Authors: Martínez Sánchez Miguel
Published: December 2017

Se presentan los resultados obtenidos tras la actualización de los datos sobre el patrimonio epigráfico romano de la ciudad de Cartagena (España), digitalizados en una base de datos y representados en mapas para un mejor estudio arqueológico. Mediante el traslado a ordenador de toda la información bibliográfica y catalográfica existente hasta 2015, se ha podido crear una hoja de cálculo de manejo más cómodo para el trabajo de investigación. Por otro lado, mediante software GIS se ha representado espacialmente la localización de las piezas en un formato que permita estudiar la distribución espacial y trasladar los datos a software vectorial. Mediante este sistema de trabajo se ha pretendido crear un archivo consultable y actualizable en línea que facilite el trabajo arqueológico de los profesionales y el acceso a la cultura del público no especializado. También se plantea la posible creación de una página web donde se pueda difundir la información de estos epígrafes al público, a modo de complemento para los impulsores del turismo cultural y para acercar al patrimonio cultural cartagenero a todos los interesados en la epigrafía de época romana.
Prevalência e Fatores Associados com o Consumo de Benzodiazepínicos por Acadêmicos de Enfermagem e Farmácia de uma Faculdade Particular do Sudoeste da Bahia
Authors: Ribeiro Bruno Silva , Rodrigues Rafael Luiz De Araújo , Duarte Stênio Fernando Pimentel
Published: December 2017

Com o objetivo de estimar a frequência de uso de benzodiazepínicos e seus determinantes entre acadêmicos de enfermagem e farmácia de uma instituição privada do sudoeste da Bahia, realizou-se um estudo transversal com 135 e 249 estudantes dos respectivos cursos, que responderam um questionário semiestruturado analisado através da estatística descritiva. A prevalência da frequência de uso foi maior para o Clonazepam e o Diazepam, sendo que os usuários evidenciaram ter feito uso ao menos uma vez na vida motivados pela ansiedade e falta de sono, em contrapartida pode-se constatar que a sonolência excessiva foi o efeito colateral mais prevalente. Conclui-se que o consumo de benzodiazepínicos entre os universitários é problema que deve ser enfrentado através da implantação de ações preventivas, ampliando a discussão dessa temática de forma interdisciplinar visando o uso racional a fim de reduzir danos a saúde que essa prática ocasional.
Avaliação do Perfil da Assistência Farmaceutica dos Munícipios do Sudoeste da Bahia
Authors: Teixeira Silvana Rocha , Teles Mauro Fernandes , Moreira Pablo Maciel Brasil
Published: December 2017

Com a Política Nacional de Medicamentos a Assistência Farmacêutica passa a ser compreendida como ponto complementar nas práticas desenvolvidas para promoção, prevenção e recuperação à saúde, ultrapassando a simples aquisição e distribuição de medicamentos. Entretanto os municípios brasileiros encontram dificuldades para cumprir as diretrizes dessa política. Este estudo objetiva avaliar a capacidade de gestão da Assistência Farmacêutica dos municípios vinculados a Microrregião de Saúde do Sudoeste Baiano. Trata-se de um estudo de corte transversal quali-quantitativo, realizado com os 12 municípios vinculados a Microrregião Região de Saúde do Sudoeste da Bahia que aceitaram participar da pesquisa por meio da aplicação de questionário virtual, adaptado. Os resultados mostram que os farmacêuticos que trabalham na Assistência Farmacêutica dos municípios possuem uma faixa salarial que varia entre 1300 a 4000 reais, com carga horária de 20 a 40 horas semanal, onde 50% deles possuem um segundo vínculo empregatício. A maioria dos municípios encontra dificuldade em realiza gestão técnica, não possui uma Comissão de Farmácia e Terapêutica (CFT), não utilizam Manual de Boas práticas de Armazenamento e Distribuição de medicamentos nem POP’s (Protocolos Operacional Padrão). Desmontaram objeção para cumprir as etapas do ciclo da Assistência Farmacêutica e garantir o uso racional de medicamentos da população. Conclui-se então que apesar dos avanços ocorridos na consolidação do SUS, em particular na Assistência Farmacêutica, os municípios ainda se deparam com dificuldades, em gerenciar e executar ações básicas que envolvem a Assistência Farmacêutica o que pode levar a deficiência no acesso da população ao medicamento.
Avaliação da Adesão ao Tratamento Farmacológico de Doenças Crônicas e Fatores Associados em Indivíduos Residentes na Zona Rural do Município de Poções-Bahia
Authors: Santos Dilma Ferreira dos , Dos Santos Stifanny Brenda Alves , Lemos Larissa Morgan Andrade
Published: December 2017

Estudos tem demonstrado que as Doenças Crônicas Não Transmissíveis são consideradas um grande problema de saúde pública, tendo a Hipertensão e Diabetes Mellitus como agravantes para este cenário. Este estudo exploratório, com abordagem quantitativa, foi realizado em uma farmácia comunitária privada e teve como objetivo avaliar a adesão ao tratamento farmacológico da hipertensão arterial e/ou diabetes e identificar o perfil sócio demográfico, correlacionando os fatores associados em pacientes moradores da zona rural de um município do interior da Bahia.  Para coleta de dados foi utilizado um questionário estruturado com questões sobre o perfil sócio demográfico, condições de saúde e uso de medicamentos. Participaram deste estudo, 250 pessoas portadores de hipertensão e/ou diabetes. Os dados apresentados neste estudo demonstram que a falta de adesão para o tratamento farmacológico das doenças crônicas pode acarretar comorbidades e, muitos outros problemas irreversíveis para a população envolvida. A adesão terapêutica poderia ser melhorada com protocolos de tratamento direcionado a cada realidade territorial.
Uma Análise da Aprendizagem da Matemática na Educação
Authors: Souza Janiere Ribeiro de , Felizardo João Everaldo Alves
Published: December 2017

Este artigo busca mostrar os processos de aprendizagem da matemática na educação infantil. Desta forma, procuramos discutir estratégias para uma pedagogia que valorize os jogos matemáticos. No âmbito da Educação Infantil, o jogo estimula o desenvolvimento de suas atividades cognitivas e manipulativas. Em função disso percebemos que a ludicidade é de grande importância para o futuro dos mesmos, pois ela propõe um grande avanço intelectual. Os jogos e brincadeiras desperta na criança um bom nível de conhecimento, sendo este de grande favorecimento para uma educação de qualidade..Para atingir os objetivos propostos em explorar ideias referentes aos números utilizados tratar-se-á como base da reflexão as teorias dos seguintes pensadores: Kishimoto (2009), DIAS (2010), BICUDO (1999).
Satisfação e Insatisfação dos Agentes Comunitários de Saúde no Trabalho, no Município de Itapetinga-Bahia
Authors: Santos Ioneide Silva , Araújo Giovana Fernandes
Published: December 2017

O presente estudo tem por objetivo geral: Analisar os fatores de satisfação e insatisfação no trabalho dos Agentes Comunitários de Saúde num município do sudoeste da Bahia. Trata-se do tipo de estudo exploratório-descritivo de natureza qualitativa, realizada em três unidades de Estratégia de Saúde da Família (ESF). Os dados foram coletados através de entrevista gravada por meio de roteiro semiestruturado. A amostra foi formada por 22 participantes, 5 são do gênero masculino e 17  feminino. A partir da análise das entrevistas emergiram quatro categorias: Motivos de Satisfação no trabalho; Fatores de Insatisfação no Trabalho; Fatores de Dificuldades no Trabalho; Meios facilitadores na realização do trabalho. O presente estudo alcançou o objetivo proposto e permitiu compreender que a rotina do agente comunitário imprime sentimentos de satisfação e insatisfação no trabalho. Os depoimentos coletados evidenciaram a necessidade de mais apoio e proteção à saúde desses trabalhadores por parte do empregador, neste caso, o poder público municipal.
Recreation in different cultures: analysis of leisure time activities
Farklı kültürlerde rekreasyon: Serbest zaman aktivitelerinin incelenmesi
Authors: Duyan Mehdi
Published: December 2017

In the new world order, societies have begun to pursue a policy aimed at achieving individuals’ appreciating their leisure time, enjoying it, and succeeding in increasing business productivity. Individuals who use their leisure time effectively are regarded healthy emotionally, spiritually, mentally, socially, professionally and physically. It is aimed to examine recreation and leisure time activities in different cultures by considering the similarity or differences between the Turkish society and the leisure time activities of the societies living in different regions of the world. In this study, domestic and international recreation activities were examined and information was obtained by literature screening method. Countries where leisure time activities are studied in different cultures; Turkey, America, Germany, England, China, Australia. As a result, it is noteworthy that in Turkish, American and British society, the rate of watching television, which is regarded as passive recreation activity, is higher than other leisure time activities. In the German and Australian communities, outdoor recreational activities and sport recreational activities are more likely to participate while Chinese society has more participation in traditional sports and cultural activities.Extended English abstract is in the end of Full Text PDF (TURKISH) file.ÖzetYenidünya düzeninde toplumlar, serbest zamanlarını iyi değerlendiren, haz ve keyif alan, iş verimliliğini artırmayı başaran bireyler elde etmeyi hedefleyen bir politika izlemeye başlamışlardır. Serbest zamanlarını etkili ve verimli kullanan bireylerin duygusal, ruhsal, zihinsel, toplumsal, mesleki ve fiziksel olarak sağlıklı olma hali söz konusudur. Türk toplumu ve dünyanın farklı bölgelerinde yaşayan toplumların serbest zaman aktiviteleri arasında benzerlik veya farklılıklar olup olmadığı düşüncesinden yola çıkılarak,  farklı kültürlerde rekreasyon, serbest zaman aktivitelerinin incelenmesi amaçlanmıştır. Bu çalışmada,  yurt içi ve yurtdışı rekreasyon çalışmaları incelenmiş ve literatür tarama yöntemi ile bilgiler elde edilmiştir. Farklı kültürlerde serbest zaman aktivitelerinin incelendiği ülkeler; Türkiye, Amerika, Almanya, İngiltere, Çin, Avustralya. Sonuç olarak, Türk, Amerikan ve İngiliz toplumunda, pasif rekreasyon faaliyeti olan televizyon seyretme oranının diğer serbest zaman aktivitelerine göre yüksek değerlerde olması dikkat çekicidir. Almanya ve Avustralya toplumunda açık hava rekreasyon faaliyetleri ile sportif rekreasyon aktivitelerine katılımın fazla olduğu, Çin toplumunda geleneksel sporlara ve kültürel faaliyetlere daha fazla katılım olduğu görülmektedir.
KPM VERSUS PELNI: PERSAINGAN MEREBUT HEGEMONI JARINGAN PELAYARAN DI NUSANTARA, 1945–1960
Authors: Surowo Bambang
Published: December 2017

This study examines the competition between KPM versus PT Pelni in seizing the network hegemony cruise in the archipelago in 1945 to 1960 using the historical method. KPM is a major shipping company that was also founded by two major companies Rotterdamsche Lloyd (RL) and Stoomvaart Maatschappij Nederland (SMN) headquartered in Amsterdam the Netherlands. KPM serve scheduled regular shipping route for passengers and cargo between islands in the Dutch East Indies then more popular with the term as a post cruise between islands. KPM also play an important role to support and assist the colonial government in the process of penetration and pacification (conquest), especially in areas outside Java. On the other hand, PT PELNI established by the Indonesian government in the framework of the national development of a country that is still young, especially in the field of shipping. PELNI as well as KPM, also serves as centraal vervoersapparaat. Therefore, the government considers KPM c.q PELNI that dominate the cruise between islands in Indonesia are competitors and inhibitors of national development in the field of shipping. Post-transfer of sovereignity and the cancellation of the agreement KMB unilaterally by President Sukarno on May 3, 1956 resulted in the position of Dutch companies including KPM are at stake. This was exacerbated by the outbreak of the conflict between Indonesia and the Netherlands on Dutch New Guinea or West Papua, Indonesia implement the program so that the overall nationalization of the Dutch companies, including KPM.
Ragam Kuliner Sesaji Dalam Upacara Tradisi di Kabupaten Jepara
Authors: Indrahti Sri , Maziyah Siti , Alamsyah Alamsyah
Published: December 2017

This article is one of wide studies that analyze culinary food served in cultural activities at Jepara. Those cultural activities become tourist attractions. This study uses qualitative method includes collection of primary and secondary sources such as literature study, observation, structured and in-depth interviews, and Focus Group Discussion (FGD). Historically, cultural activities have been existed during the ancestor period, it is always accompanied by the presence of culinary that has philosophical and historical significance among them. The purpose of this study is to develop culinary culture into business units for the community by combining cultural and tourism market values that have been existed previously. The culinary varieties are expected to be able to contribute in tourism development through the establishment of new business units.
Melestarikan dan Mengembangkan Warisan Budaya: Kebijakan Budaya Semarangan Dalam Perspektif Sejarah
Authors: Puguh Dhanang Respati
Published: December 2017

Semarang has developed as a diverse city. The communities who lived in Semarang history has produced a hybrid culture patterned Semarang which in the next time become as "Semarangan culture". At that time of Indonesia's independence there is awareness to preserve the cultural heritage of Semarangan either by local governments and communities of Semarang. The preservation and development cultural heritage of Semarangan continues which among other things aims to establish a cultural identity for the community and theie city. However, such efforts have not been able to achieve the expected results, because the Semarangan culture is less able to perform in a stage of cultural life in their own city and national culture.
Dinamika Gerakan Lingkungan dan Global Environmental Governance
Authors: Rochwulaningsih Yety
Published: December 2017

Melalui metode sejarah kritis dengan pendekatan politik ekologi, tulisan ini mengkaji peristiwa bencana alam tanah longsor yang menjadi ancaman serius terhadap kehidupan masyarakat. Intensitas bencana tanah longsor yang semakin tinggi dan merata di berbagai kawasan di Indonesia tidak terlepas dari kebijakan ekonomi politik pemerintah dalam memanfaatkan sumber daya alam dan masifnya penetrasi sistem ekonomi kapitalis global yang sangat ekspansif dan eksploitatif terhadap sumber daya alam. Fakta empirik implementasi UU No.5/1967, UU No. 11/1967, UU No. 5/1990, dan TAP MPR No IX/2001, justru menjadi pintu masuk bagi pemanfaatan sumber daya alam melebihi carrying capacity yang berdampak terhadap kerusakan ekosistem dan bencana alam yang menjadi ancaman serius kehidupan masyarakat.
Editorial
Authors: Amaruli Rabith Jihan
Published: December 2017

Pada mulanya politik dianggap sebagai tulang punggung sejarah, demikian dinyatakan oleh Kuntowijoyo (2003: 174). Oleh karena itu pula, lanjutnya, teks-teks sejarah selalu berisi rentetan kejadian mengenai raja, negara, bangsa, pemerintahan, parlemen, pemberontakan, kelompok-kelompok kepentingan, dan interaksi antara kekuatan-kekuatan itu dalam memperebutkan kekuasaan. Namun demikian, anggapan ini pun mengalami perubahan. Sejarah semakin diperluas dengan berbagai aspek lain di luar politik, yakni dengan kemunculan sejarah sosial, sejarah ekonomi, dan sejarah kebudayaan. Hal itu karena, orang mulai meragukan keterkaitan antara sejarah dan politik dalam hubungan yang melulu tentang kekuasaan. Selain itu, cara orang melihat dan mengerjakan sejarah politik itu sendiri pun, mulai berubah. Akibatnya, tema-tema dalam sejarah politik pun semakin berkembang, dengan kemunculan sejarah politik tentang lingkungan, keagamaan, perkotaan, bahkan pendidikan. Tema-tema inilah yang menjadi warna dalam Jurnal Sejarah Citra Lekha Volume 2, Nomor 2 Tahun 2017 kali ini.Pada mulanya politik dianggap sebagai tulang punggung sejarah, demikian dinyatakan oleh Kuntowijoyo (2003: 174). Oleh karena itu pula, lanjutnya, teks-teks sejarah selalu berisi rentetan kejadian mengenai raja, negara, bangsa, pemerintahan, parlemen, pemberontakan, kelompok-kelompok kepentingan, dan interaksi antara kekuatan-kekuatan itu dalam memperebutkan kekuasaan. Namun demikian, anggapan ini pun mengalami perubahan. Sejarah semakin diperluas dengan berbagai aspek lain di luar politik, yakni dengan kemunculan sejarah sosial, sejarah ekonomi, dan sejarah kebudayaan. Hal itu karena, orang mulai meragukan keterkaitan antara sejarah dan politik dalam hubungan yang melulu tentang kekuasaan. Selain itu, cara orang melihat dan mengerjakan sejarah politik itu sendiri pun, mulai berubah. Akibatnya, tema-tema dalam sejarah politik pun semakin berkembang, dengan kemunculan sejarah politik tentang lingkungan, keagamaan, perkotaan, bahkan pendidikan. Tema-tema inilah yang menjadi warna dalam Jurnal Sejarah Citra Lekha Volume 2, Nomor 2 Tahun 2017 kali ini.
A Case Study of Six Sigma Define-Measure-Analyze-Improve-Control (DMAIC) Methodology in Garment Sector
Authors: Rahman Abdur , Shaju Salaha Uddin Chowdhury , Sarkar Sharan Kumar , Hashem Mohammad Zahed , Hasan S. M. Kamrul , Mandal Ranzit , Islam Umainul
Published: December 2017

This paper demonstrates the empirical application of Six Sigma and Define-Measure-Analyze-Improve-Control (DMAIC) methodology to reduce product defects within a garments manufacturing organization in Bangladesh which follows the DMAIC methodology to investigate defects, root causes and provide a solution to eliminate these defects. The analysis from employing Six Sigma and DMAIC indicated that the broken stitch and open seam influenced the number of defective products. Design of experiments (DOE) and the analysis of variance (ANOVA) techniques were combined to statistically determine the correlation of the broken stitch and open seam with defects as well as to define their optimum values needed to eliminate the defects. Thus, a reduction of about 35% in the garments defect was achieved, which helped the organization studied to reduce its defects and thus improve its Sigma level from 1.7 to 3.4.