bluuebunny/crossref_metadata_2025 huggingface dataset:
Human TNF-α Affects the Egg-laying Dynamics and Glucose Metabolism of Schistosoma Mansoni Adult Worms in Vitro
Authors: Lopes-Junior Ednilson Hilário , Silveira Gilbert de Oliveira , Guedes Camila Banca , Rodrigues Gratchela Dutra , Ribeiro Viviane Sousa , Amaral Murilo Sena , Kanamura Cristina Takami , Pinto Pedro Luiz Silva , Krüger Rodrigo Ferreira , Verjovski-Almeida Sergio , Oliveira Katia C.
Published: September 2021

Several studies described the effect of human TNF-α on Schistosoma mansoni. It affects the worm’s development, metabolism, egg-laying, changes in the parasite´s gene expression and protein phosphorylation. Data available concerning the influence of hTNF-α on egg-laying are controversial and understanding the mechanism of egg-laying regulation is essential in combating schistosomiasis. We characterized the effects of in vitro treatment of S. mansoni adult worms with different doses of hTNF-α (5, 20 and 40ng/mL) for five days. We explored the effects on the egg-laying rate, glucose, ATP metabolism, mRNA expression levels of lactate dehydrogenase, of glucose transporters and of SmTNFR, the parasite gene for hTNF-α receptor. hTNF-α influenced egg-laying in a time and dose dependent manner: with 40ng/mL, egg-laying increased on day 2 and decreased on days 3 and 4; 20 ng/mL dose, egg-laying decreased on day 3, while at 5ng/mL dose, egg-laying decreased on day 4. The total number of eggs produced was not affected, but the egg-laying dynamic was altered; the median egg-laying time decreased significantly due to treatment. At 5 and 20ng/mL hTNF-alpha, lactate production diminished on days 3 up to 5, while glucose uptake increased on day 5. At 40ng/mL, glucose uptake diminished on days 1 up to 3, while ATP accumulation was detected on day 5. No significant changes in the mRNA expression were detected in all treatments. Crosstalk involving the hTNF-alpha and the parasite signaling play a role in the fine regulation of the worm´s metabolism and physiology and points to new strategies for disease control.
cGAS-STING Signaling Pathway Mediates Brain Trauma-Induced Type I Interferon Response
Authors: Fritsch Lauren , Ju Jing , Basso Erwin Kristobal Gudenschwager , Soliman Eman , Paul Swagatika , Chen Jiang , Kowalski Elizabeth , Tuhy Taylor C , Somaiya Rachana D , Wang Xia , Allen Irving C , Theus Michelle H , Pickrell Alicia M
Published: September 2021

Background Inflammation is a key contributor of neuronal death and dysfunction following traumatic brain injury (TBI). Recent evidence suggests that interferons may be a key regulator of this response. Our studies evaluated the role of the Cyclic GMP-AMP Synthase-Stimulator of Interferon Genes (cGAS-STING) signaling pathway a murine model of TBI. Methods Male, eight-week old wildtype, STING knockout ( -/- ), cGAS -/- , and NLRX1 -/- mice were subjected to controlled cortical impact (CCI) or sham injury. Histopathological evaluation of tissue damage was assessed using non-biased stereology, which was complemented by analysis at the mRNA and protein level using qPCR and western blot analysis, respectively. Results We found that STING and Type I interferon-stimulated genes were upregulated after CCI injury in a bi-phasic manner and that loss of cGAS or STING conferred neuroprotection concomitant with a blunted inflammatory response at 24 hours post-injury. cGAS -/- animals showed reduced motor deficit 4 days after injury (dpi), and amelioration of tissue damage was seen in both groups of mice up to 14 dpi. Given that cGAS requires a cytosolic damage- or pathogen- associated molecular pattern (DAMP/PAMP) to prompt downstream STING signaling, we further show that mitochondrial DNA is present in the cytosol after TBI. Finally, our findings demonstrate that NLRX1 may be an additional regulator that functions upstream to regulate cGASSTING pathway. Conclusions These findings suggest that the canonical cGAS-STING-mediated Type I interferon signaling axis is a critical component of neural tissue damage following TBI and that mtDNA may be a possible trigger in this response.
Malignant Migrating Partial Seizures of Infancy (MMPSI): Expansion of Clinical Phenotypic and Genotypic Spectra
Authors: wu liwen , Cai Fang , Gan Siyi , Yang Sai , Yang Xiaofan , Yang haiyan
Published: September 2021

BackgroundMMPSI is a rare early infantile epileptic encephalopathy with unknown etiology and poor prognosis. With the development of genetic techniques, an increasing number of novel pathogenic genes have been shown to be related to MMSPI. This study included 36 patients who were diagnosed with MMPSI; the clinical features, etiology, treatment strategies and outcomes of these patients were determined to explore new genetic etiology and new precision medicine treatment strategies.Results36 patients were enrolled. The main seizure types were focal, tonic and spasms. The main EEG findings were seizure migration and hypsarrhythmia. 17/36 cases had causative variants across 11 genes, including 6 novel MMPSI genes: PCDH19, ALDH7A1, DOCK6, PRRT2, ALG1 and ATP7A. 13/36 patients had ineffective seizure control, 14/36 patients had severe retardation and 6/36 patients died. Of them, the genes for ineffective seizure control, severe retardation or death include KCNT1, SCN2A, SCN1A, ALG1, ATP7A and WWOX. Genes associated with seizure-free, mild-moderate retardation or normal development included PRRT2, SCN2A, ALDH7A1 and PNPO. Vitamin B6 allowed patients with ALDH7A1 and PNPO mutations to achieve seizure-free status, oxcarbazepine was effective for patients with SCN2A, ATP7A, WWOX, and PRRT2 mutations, and ACTH was partly effective for DOCK6 mutation patients with spasms and hypsarrhythmia. 17 patients had abnormal MRI, of which 8 had ineffective seizure control, 7 had severe retardation and 4 (4/17, 23.5%) died. 13 patients had hypsarrhythmia, of which 6 had ineffective seizure control, 6 had severe retardation and 2 died. Also, 7 patients had burst suppression, of which 1 had ineffective seizure control, 3 had severe retardation and 3 died.ConclusionThis study is the first to report that ALDH7A1, ATP7A, DOCK6, PRRT2, ALG1, and PCDH19 mutations cause the phenotypic spectrum of MMPSI to expand the genotypic spectrum. The genes KCNT1, SCN2A, SCN1A, ALG1, ATP7A and WWOX may be associated with poor prognosis. The patients presenting with MRI abnormalities, hypsarrhythmia and burst suppression in EEG may be associated with poor prognosis. Through early diagnosis with genetic tests and the administration of the corresponding precise treatment, the outcomes of MMPSI can be notably improved.
Acid Base and Blood Gas Analysis in Term Neonates Immediately After Birth with Uncomplicated Neonatal Transition
Authors: Baik-Schneditz Nariae , Schwaberger Bernhard , Urlesberger Berndt , Wolfsberger Christina Helene , Bruckner Marlies , Pichler Gerhard
Published: September 2021

Background: Acid base and blood gas measurements provide essential information, especially in critically ill neonates. After birth, rapidly changing physiology and difficulty to obtain blood samples represent unique challenges.Objectives: The aim of the present study was to establish normal values of capillary acid base and blood gas analysis immediately after birth in term neonates after uncomplicated neonatal transition.Method: This is a post-hoc- analysis of ancillary outcome parameter of a prospective observational study in term neonates immediately after caesarean section. Neonates were included after immediate neonatal transition without need of medical support and a capillary blood sample was taken by a heel-stick within 15-20 minutes after birth.Result: 132 term neonates were included with mean (SD) gestational age of 38.7±0.7 weeks. The blood was drawn mean (SD) 16±1.7 minutes after birth. The mean (SD) values of the analyses were: pH 7.30±0.04, pCO2 52.6±6.4, base excess -0.9±1.7 and bicarbonate 24.8±1.6.Conclusion: This is the first study describing acid base and blood gas analyses in term neonates immediately after birth with uncomplicated neonatal transition.
Accuracy and Safety of In-House Surgeon-Designed Three-Dimensional Printed Patient Specific Implants for Wafer-Less Le Fort I Osteotomy
Authors: LEUNG Yiu Yan , LEUNG Jasper Ka Chai , LI Alvin Tsz Choi , TEO Nathan En Zuo , LEUNG Karen Pui Yan , AU Shun Wai , LI Dion Tik Shun , SU Yu-Xiong
Published: September 2021

The design and fabrication of three-dimensional (3D) -printed patient-specific implants (PSIs) for orthognathic surgery are customarily outsourced to commercial companies. We propose a protocol of designing PSIs and surgical guides by orthognathic surgeons-in-charge instead for wafer-less Le Fort I osteotomy. The aim of this prospective study was to evaluate the accuracy and post-operative complications of PSIs that are designed in-house for Le Fort I osteotomy. The post-operative cone beam computer tomography (CBCT) model of the maxilla was superimposed to the virtual surgical planning to compare the discrepancies of pre-determined landmarks, lines and principal axes between the two models. Twenty-five patients (12 males, 13 females) were included. The median linear deviations of the post-operative maxilla of the x, y and z axes were 0.74 mm, 0.75 mm and 0.72 mm, respectively. The deviations in the principal axes for pitch, yaw and roll were 1.40°, 0.90° and 0.60°, respectively. There were no post-operative complications related to the PSIs in the follow-up period. The 3D-printed PSIs designed in-house for wafer-less Le Fort I osteotomy are accurate and safe. Its clinical outcomes and accuracy are comparable to commercial PSIs for orthognathic surgery.
Integrative Analysis of DNA Methylation and Gene Expression in Skin Cutaneous Melanoma by Bioinformatic Approaches
Authors: Sun Yan , Wu Zhilin , Chen Rui , Wu Yan , Lin Yun
Published: September 2021

Skin cutaneous melanoma is the most life-threatening skin cancer. Finding key methylation genes of prognostic value is an under-explored but intriguing field in the research of skin cutaneous melanoma. This work is aimed to identify survival related methylated genes and their specific methylation sites in skin cutaneous melanoma via an integrative analysis with bioinformatic approaches. The original data, including gene methylation and expression files, were downloaded from the Cancer Genome Atlas database. Statistical analysis revealed that skin cutaneous melanoma patients with highly expressed and hypomethylated HHEX had a better outcome than patients with lowly-expressed and hypermethylated HHEX. In addition, fifteen methylation sites of HHEX were identified to be significantly correlated with HHEX expression changes. In various pathological stages, the expression levels of HHEX were different, and exhibited a downward trend from stage Ⅰ to stage Ⅳ. Therefore, we speculate that the driven gene HHEX may play an important role in the survival of skin cutaneous melanoma. This finding provides novel epigenetic molecular clues and potential detection targets for early prediction of the prognosis of skin cutaneous melanoma.
Melatonin-induced cold and drought tolerance requires brassinosteroids and hydrogen peroxide signaling in perennial ryegrass
Authors: Fu Juanjuan , Zhang Shentong , Jiang Huina , Zhang Xinfei , Gao Hao , Yang Peizhi , Hu Tianming
Published: September 2021

Aims The interplay between melatonin and brassinosteroids in enhancing tolerance to cold and drought and the underlying molecular mechanisms of this relationship still remain unknown. Methods Combined physiological and transcriptomic analyses were used to clarify the crosstalk of melatonin and brassinosteroids in perennial ryegrass. Brassinosteroids biosynthesis inhibitor propiconazole, Arabidopsis brassinosteroids-receptor mutant bri1-9, bak1, and H2O2 deficient rbohC and rbohF mutants were used to analyzed the role of H2O2 in melatonin and brassinosteroids-mediated tolerance to the stress. Results Melatonin-enhanced cold and drought tolerance of perennial ryegrass depends on the duration of dose and stress that were applied. Melatonin activates the expression of NADPH oxidase-related genes to promote H2O2 production when exposed to short-term cold/drought stresses but reduced accumulation of H2O2 under long-term stress. This was associated with an increase in enzymatic and non-enzymatic antioxidant activities by regulation of their gene expression and modulation of the ascorbate-glutathione cycle. Moreover, exogenous melatonin increased the biosynthesis of melatonin and brassinosteroids or the expression of signaling-related genes. However, the effects of melatonin on the expression of BR biosynthesis and signaling-related genes were inhibited in the rbohC and rbohF mutants. Chemical scavenging of H2O2 attenuated melatonin-mediated growth in the Arabidopsis wild-type, but the bak1 and bri1.9 mutants were relatively insensitive. Consistently, Inhibition of H2O2 production impaired the effect of melatonin and brassinosteroids on seed germination and the root growth of perennial ryegrass. Conclusions This research reveals a novel regulatory mechanism of the crosstalk of H2O2 and brassinosteroid signaling in melatonin-induced cold/drought tolerance in perennial ryegrass.
Modeling the electron orbital in transition subatomic structure
Authors: Ivantsov M.
Published: September 2021

As part of the well-known task about a motion of charged particle in central forces field, a certain parallelism for electronic distribution between the atomic and subatomic ''orbits'' can be established.In this conjuncture the ground state of muonium atom as in transition electron-nuclear structure is highlighted. Moreover, there is specifically nuclear solution of fine-structure constant which with a hyper-fine structure, like of the Lamb shift of hydrogen atom, is unambiguously associated.Such a special approach, in the terms of electric interaction, may serve as an extension to the existing meson-boson classification.In particular, some idea about a versatility of the Higgs mechanism in nuclear reactions put forward for consideration here.But it would be just spatial abstraction, where subatomic matter expands as into infinity. And what would be beyond the edge of the universe?
‚Eine Halle für alle – den Lernort Sporthalle barrierefrei gestalten‘ – Ein Seminarangebot der inklusionsorientierten Sportlehrer*innenausbildung aus Studierendensicht
Authors: Bükers Frederik , Wibowo Jonas , Schütt Marie-Luise
Published: September 2021

Teilhabemöglichkeiten können durch mangelnde Barrierefreiheit eingeschränkt sein, dies gilt im Kontext des Sportunterrichts auch für den Lernort Sporthalle. Mit dem Hochschulseminar ‚Eine Halle für alle – den Lernort Sporthalle barrierefrei gestalten‘ wird das Ziel verfolgt, angehende Sportlehrer*innen in die Lage zu versetzen, materiell-räumliche Barrierepotenziale am Lernort Sporthalle zu identifizieren und sie im Umgang mit diesen zu stärken. Das Seminarkonzept strebt eine Theorie-Praxis-Verknüpfung an und orientiert sich hierfür an Merkmalen des situierten Lernens. Eine qualitative Interviewstudie zum Seminarkonzept dient der formativen Evaluation, setzt an der Perspektive der Studierenden an und legt den Schwerpunkt zum einen auf die Umsetzung der Merkmale des situierten Lernens und zum anderen auf den Lerngegenstand ‚Der Lernort Sporthalle unter besonderer Berücksichtigung der Barrierefreiheit‘. In diesem Beitrag werden das Seminarkonzept und die Evaluationsergebnisse dargestellt.
 
Abstract
Lack of accessibility can limit participation. In the context of physical education (PE), this also applies to the sports hall as a part of the learning environment. The higher education seminar ‚Eine Halle für alle – den Lernort Sporthalle barrierefrei gestalten‘ aims to enable pre-service PE teachers to identify potential barriers in the sports hall and to strengthen them in dealing with them. The seminar concept aims to bridge theory and practice and is based on the characteristics of situated learning. It was evaluated through a qualitative interview study. The evaluation was based on the perspective of the students and focuses on the one hand on the implementation of the characteristics of situated learning and on the other hand on the learning object 'The barrier-free sports hall'. In this article, the seminar concept and evaluation results are presented.
Shifting the operating frequency of the piezoceramic electroacoustic transducer langevin type using passive cooling methods
Authors: Perchevska Liudmyla , Drozdenko Oleksandr , Drozdenko Kateryna
Published: September 2021

The object of research: the shift of resonant frequency of the piezoceramic electroacoustic transducer Langevin type depending on the shape of the back plate.

Investigated problem: the relationship between changes in shape of back plate of the Langevin type transducer with the resonant frequency of the oscillating system.  Search quantitative contribution to shift the resonant frequency of each of the modifications: shape, diameter, thickness, weight of back plate.

The main scientific results: vibration modes of a transducer with a back plate with horizontal and vertical radiator ribs were obtained. The graphs of the shift resonant frequency depending on the change in the diameter and thickness of the back tail with vertical radiator ribs are presented. It is established, that the change in the thickness and diameter of the back plate of the transducer effects on resonance frequency much less than the change in mass.

The area of practical use of the research results: designing piezoceramic electroacoustic transducer with passive cooling method.

Innovative technological product: guidelines for choosing the shape changes back plates of the Langevin type transducer for decreasing heating temperature, with keeping resonant frequency.

Scope of the innovative technological product: scope of application of the Langevin type transducer: underwater acoustics, ultrasonic technological equipment, ultrasonic engine, piezotransformer, medical equipment, rock drilling devices.
Cutting forces when grinding parts from martensite aging steels with highporous abrasive, borazon and diamond wheels
Authors: Lebedev Vladimir , Bespalova Alla , Chumachenko Tatiana , Omelchenko Yevhen , Nikolaieva Tatiana
Published: September 2021

Object of research. The article investigates the cutting forces when grinding martensitic-aging steels with highly porous grinding wheels.

The problem to be solved is the regularities of the change in the magnitude of the cutting forces when grinding maraging steels with highly porous CBN wheels.

Main scientific results. The studies were performed on martensiticaging steel H8K18M14. As a result of the experiments, it was found that when grinding wheels made of materials such as electrocorundum, CBN (borazon) and diamond, a significant role is played by the values of the cutting force, which increase during processing.

During the experiment it was found out: the cutting forces Py and Pz in the width of the allowable modes, which are most often used in circular and flat grinding, can reach the following values: with the structure of the wheel 26 come to values from 2.714N to 30.721 and with the structure of the wheel 40 come to values from 2.49N to 28.185N.

Reducing the grain size of the wheel, let’s obtain the effect of increasing the energy costs of the grinding process, by increasing the magnitude of the cutting forces.

If to compare the cutting forces that occur when grinding different wheels, it is possible to note the following: in comparison with electrocorundum wheels when using wheels with KNB cutting forces are reduced by 20-25 %, and when grinding with diamond wheels, the effect of cutting forces is reduced by 25 - 30 %. When grinding with highly porous wheels, the cutting force is 15-20 % higher than when grinding with wheels of normal porosity.

The area of practical use of research results-grinding technology for maraging steels.

Innovative technological product – relationship between processing modes and the magnitude of cutting forces when grinding maraging steels.

Scope of application of an innovative technological product-mechanical engineering technology
A new reciprocal Rayleigh extension: properties, copulas, different methods of estimation and a modified right-censored test for validation
Authors: Yousof Haitham M. , Masoom Ali M. , Goual Hafida , Ibrahim Mohamed
Published: September 2021

In this article, a new reciprocal Rayleigh extension called the Xgamma reciprocal Rayleigh model is defined and studied. The relevant statistical properties are derived, and the useful results related to the convexity and concavity are addressed. We discussed the estimation of the parameters using different estimation methods such as the maximum likelihood estimation method, the ordinary least squares estimation method, the weighted least squares estimation method, the Cramer-Von-Mises estimation method, and the bootstrapping method. A simulation study was conducted to assess the performances of the proposed estimation methods are investigated through a simulation study. Many bivariate and multivariate type model have also been derived based on Farlie-Gumbel-Morgenstern copula, the Clayton copula, Renyi’s entropy copula and the Ali-Mikhail-Haq copula. A modified Nikulin-Rao-Robson test for right-censored validation is applied to a censored real data set.
Índice da sustentabilidade na Região do Submédio São Francisco, Pernambuco, Nordeste do Brasil
Authors: Cardoso Ariane Silva , Melo Andreza dos Santos Rodrigues de , Marques Érika Alves Tavares , Casé Maristela , Oliveira Cláudia Ricardo de , Sobral Maria do Carmo Martins
Published: September 2021

Os indicadores da sustentabilidade são um meio de verificar, quantificar e monitorar informações e ações que estão sendo realizadas, além de servir como base a índices que irão subsidiar estratégias para alcançar o desenvolvimento sustentável. A Região do Submédio São Francisco, situado na região semiárida entre os Estados da Bahia e Pernambuco, sofre influência de diversos impactos socioambientais e econômicos. Buscou-se neste artigo, através do Índice de Desenvolvimento Sustentável, avaliar a o perfil sustentável da Região do Submédio São Francisco. O Índice de Desenvolvimento Sustentável revelou performance aceitável de desenvolvimento sustentável para a Região de Desenvolvimento do Sertão de Itaparica, mas ainda longe de ser considerado ideal. A Região de Desenvolvimento do São Francisco obteve um Índice de Desenvolvimento Sustentável com performance de alerta. De modo geral, o índice final da Região de Desenvolvimento de Itaparica ficou superior ao índice final da Região de Desenvolvimento do São Francisco, o que demonstra que o índice não privilegia o desenvolvimento econômico frente aos outros indicadores. Pode-se observar grande desigualdade entre os municípios da Região de Desenvolvimento do São Francisco, o que influenciou no índice final mais baixo.
A pegada ecológica à luz da sustentabilidade: o que dizem os estudos recentes?
Authors: Carvalho Nicole Stephanie Florentino de Sousa , Frota Antônio Jackson Alcântara , Braga Francisco Laercio Pereira , Cardoso Gil Célio de Castro
Published: September 2021

Os indicadores de sustentabilidade surgem como ferramentas ativas importantes para que a sociedade administre devidamente seus sistemas e desenvolva-se de maneira sustentável e, dentre as ferramentas disponíveis, pode-se citar a pegada ecológica. Este artigo objetiva apresentar o indicador de sustentabilidade pegada ecológica dentro da compreensão de ferramenta que viabiliza a visualização das incongruências identificadas na tangência do desenvolvimento sustentável nas sociedades por meio de estudos publicados entre 1990 a 2020. Para atingir este objetivo, trabalhou-se com estudos científicos publicados na literatura internacional e nacional, totalizando 32 trabalhos disponibilizados nas plataformas digitais de pesquisa. A seleção dos estudos publicados refere-se, basicamente, a duas dimensões importantes: i) Indicadores de sustentabilidade; e, ii) Desenvolvimento sustentável. Os resultados observados do conjunto de artigos mostraram, primeiramente, congruência dos autores no que diz respeito aos indicadores de sustentabilidade e sua relevância para a tangência do desenvolvimento sustentável, com destaque para o método da pegada ecológica. Em um segundo momento, o processo analítico dos estudos selecionados deixou evidente a ferramenta de mensuração da pegada ecológica, assim como suas vantagens e desvantagens.
Concluiu-se, assim, sobre a importância dada, nos últimos trinta anos, à discussão existente sobre a relação da pegada ecológica com o desenvolvimento sustentável.
Reproductive aspects of freshwater fishes exposed to pesticide-contamined environments: A systematic review
Authors: Santos Jadson Pinheiro , Almeida Simone de Jesus Melo , Costa Claryce Cunha , Guimarães Erick Cristofore , Teixeira Erivânia Gomes , Carvalho-Neta Raimunda Nonata Fortes
Published: September 2021

Fish are the predominant group of vertebrates in aquatic environments, and they are directly affected by the presence of contaminants in water bodies, which undergo changes in the structure and function of communities and dynamics of the populations. The aim of the present study was to conduct a systematic review of studies that analyze the reproductive aspects of freshwater teleosts in environments contaminated by pesticides. A systematic search for scientific articles was carried out from 2000 to 2019 using the "Web of Science" database, using the descriptors "fish reproduction", "contamination", "toxicology", "ecotoxicity" and "biomonitoring", combined with the use of boolean operators "AND" and "OR". The content analysis was performed based on the titles and the summary, with a first screening. Then, 98 articles were read in full, with 40 being selected. 24 species of fish were recorded, with a predominance of Danio rerio (17.5%). Insecticides were present in 78% of the studies, mainly Endosulfan (35%) and Cypermethrin (13%). Reproductive endocrine disorders were the most reported pathways of action (57.5%). The effects of pesticides on the reproduction of freshwater teleosts are evident, requiring studies on structural changes in gonads and a decrease in the quality of gametes.
Threats to the brown-throated three-toed sloth Bradypus variegatus Schinz, 1825 (Pilosa: Bradypodidae) in an urban environment in State of Paraíba, Brazil
Authors: Pedrosa Elaine Pessoa , Castro Carla Soraia Soares de , Rocha Fabiana Lopes
Published: September 2021

The brown-throated three-toed sloth Bradypus variegates Schinz, 1825 (Pilosa: Bradypodidae) is an arboreal mammal with wide distribution in the neotropical region. However, the presence of this species in urban environments has attracted attention due to the threats that this environment can offer to this species. In this context, the present study investigated the impacts over brown-throated three toed sloth’s population living in an urban area of Rio Tinto, Paraíba, as well as, analyze data from Wildlife Screening Center (Centro de Triagem de Animais Silvestres - CETAS) and the conservation units of Paraíba, to understanding threats and main factors that led individuals to these institutions. From 2011 to 2014 a sloth’s population was studied at João Pessoa Square in Rio Tinto. From 2010 to 2015 was analyzed data from CETAS, Guaribas Biological Reserve (GBR), Barra do Rio Mamanguape Environmental Protection Area (BRM-EPA) and Arruda Câmara Municipal Zoobotanical Park (AC-MZP).The place that most registered the receipt of sloths was CETAS (65.5%), followed by GBR (17.8%), AC-MZP (15%), and BRM-EPA (1.8%). Offspring were significantly more impacted than adults, because were recorded highest number of injured and dead individuals in CETAS. Offspring not survived also at João Pessoa Square in Rio Tinto (urban environment) until the reproductive phase, due to falls or the rejection of their mothers during parental care. The urbanized matrix causes changes in the parental care of the mother sloths, implying the early abandonment of their offspring. In addition, inadequate introductions of sloths at João Pessoa Square causing malnutrition in individuals due to the lack of insufficient nutrients available, and electric shocks caused by high voltage wires, resulting in death or limb amputation of adult sloths. To minimize these impacts, urban environments needs to be controlled, through tree pruning, prohibit the introductions of sloths and increase the diversity of plant species in this area.
A LOGÍSTICA REVERSA DE RESÍDUOS DE MEDICAMENTOS DOMICILIARES NO COMÉRCIO FARMACÊUTICO DO BAIRRO CENTRO, FORTALEZA, CEARÁ
Authors: Felipe Fernandes Juana Angélica , Vieira de Paula Souza Érika , Aguiar Silva Lígia Nazaré , Barros Silveira Rossana
Published: September 2021

Entre o montante de resíduos sólidos urbanos produzidos diariamente incluem-se rejeitos com características de toxicidade, inflamabilidade, corrosividade e potencial contaminante, os quais merecem atenção especial, uma vez que são classificados pela NBR nº 10.004/2004 como resíduos perigosos. Este é o caso dos resíduos de medicamentos domiciliares (RMD), como frascos, comprimidos, seringas etc., que podem ser gerados em residências e, quando descartados incorretamente, contaminam o solo e os corpos hídricos. Diante dessa problemática, a Lei cearense nº 15.192, de 19 de julho de 2012, estabeleceu a implantação da logística reversa para RMD em farmácias, drogarias e distribuidores de medicamentos, para que o consumidor final tenha acesso a alternativas corretas de descarte. Nesse contexto, o presente trabalho buscou verificar, através de pesquisa de campo para registro fotográfico e preenchimento de formulário, o atendimento à esta Lei no Centro do Município de Fortaleza, bairro com maior número de estabelecimentos farmacêuticos do município. Os resultados mostram que apenas 7% das farmácias recebiam os RMD e que em mais de 60% dos estabelecimentos é perceptível o desconhecimento da normativa em questão, indicando uma possível falha na capacitação dos profissionais desses estabelecimentos, desconhecimento do proprietário/gestor do estabelecimento ou deficiência na fiscalização desse quesito por órgãos públicos. Portanto, é necessário que o poder público atue efetivamente com políticas públicas, fiscalização e outras ações, para que fabricantes e importadores de medicamentos - base do comércio de fármacos - apoiem a logística reversa de RMD iniciada no distribuidor final, ademais de medidas de educação ambiental para o consumidor final.
ACESSIBILIDADE DE INTERFACES WEB PARA CUIDADORES COM BAIXA ESCOLARIDADE: ASPECTOS E REFLEXÕES
Authors: Capra Eliane Pinheiro , Leal Ferreira Simone Bacellar , Marques João Marcelo , Portela Samuel Santos
Published: September 2021

A evolução da internet trouxe novas perspectivas de interação e comunicação entre as pessoas, bem como muitos desafios. A interação com conteúdo textual pode ser impactada, especialmente para os analfabetos funcionais, que são pessoas com comprometimento nas habilidades de leitura e escrita ou com baixa escolaridade, de acordo com critérios estabelecidos pela UNESCO. Dentre esses usuários, pode-se encontrar os cuidadores de idosos, uma vez que boa parcela é considerada analfabeta funcional, por causa da baixa escolaridade. Este artigo trata de um levantamento de caráter exploratório, com objetivo de analisar as contribuições disponíveis na literatura acerca da acessibilidade web para esse público, identificando fatores que podem tornar a web acessível aos cuidadores analfabetos funcionais e possíveis lacunas para pesquisas futuras. Para isso, foi realizado um mapeamento sistemático seguindo a abordagem Systematic Literature Review (SLR), a fim de analisar artigos publicados entre 2000 e 2019 em quatro bases acadêmicas internacionais. Foram extraídos 58 artigos e, após triagem e leitura de 23 trabalhos, foram identificadas 12 pesquisas relacionadas ao tema. O mapeamento possibilitou a comparação entre as publicações e a identificação de aspectos que podem influenciar no desenvolvimento de interfaces acessíveis a cuidadores analfabetos funcionais, além de revelar importantes contribuições sobre recomendações, modelos, sistemas e aplicações. Espera-se que os resultados desta pesquisa possam contribuir para a conscientização dos pesquisadores sobre a importância do tema na comunidade de Interação Humano Computador (IHC).
Mediating role of entrepreneurial competencies: Influence of personality traits on entrepreneurial intention
Authors: Ketut Kusumawijaya Ida , Dwi Astuti Partiwi
Published: September 2021

This study aims to examine the role of entrepreneurial competency in mediating the influence of personality traits on entrepreneurial intention. Data were collected using a questionnaire sent to medium-sized business managers in the province of Bali, Indonesia; the sample size is 385 people. Assuming a response rate of 85%, 453 questionnaires were sent. Of these, 142 returned and a usable response rate of 30.37% was achieved. Data were analyzed using SEM-PLS with WarpsPLS 7.0. The findings show that personality traits have a significant effect on entrepreneurial competency (β = 0.513; p < 0.001), personality traits significantly affect entrepreneurial intention (β = 0.266; p < 0.001). Furthermore, this study proves that entrepreneurial competency significantly affects entrepreneurial intention (β = 0.436; p < 0.001). This study also found the Sobel test value of 5.770, which means that entrepreneurial competency can influence personality traits and entrepreneurial intention as a partial mediator. There is a comprehensive view of the relationship between personality traits, entrepreneurial competency, and entrepreneurial intention. This study not only provides an understanding of the relationship between personality traits and entrepreneurial intention, but also provides evidence on the mechanism by which entrepreneurial competency mediates the relationship between personality traits and entrepreneurial intention.
APPLICATOIN OF THE PRINCIPLE OF TRUST IN THE LAND REGISTRY IN THE CONTEXT OF THE DISPOSITION OF MARITAL ASSETS
Authors: Mutapčić Hamid , Oruč Esad
Published: September 2021

By entering into effect of the new Entity laws on the land registry, a new definition of the principle of trust is introduced, a definition that aims at the protection of the rights that have been acquired on the basis of incorrect or incomplete land registry status. However, the question arises of whether the third conscientious person will have any protection regarding the acquisition of property rights on real estate that is a part of marital assets, when such real estate is recorded in the land registry only belonging to one marital partner. In the legal theory and jurisprudence the issue of validity of the legal relation regarding the sale and the burdening of such real estate by the registered right holder has been raised. Bearing in mind the fact that in our legal system the principle of causal tradition is applied, coming to the correct position on this legal issue is very significant. Further scientific research in this area is of particular importance due to the ongoing process of the reform of land registry law, whose purpose is the reaffirmation of the land registry and the creation of legal presumptions for a faster and simpler legal disposition of real estate.
APPLICATION OF COOPERATIVE LEARNING IN EARLY MATHEMATICS TEACHING – TEACHERS’ ATTITUDES
Authors:   Faculty of Philosophy, University of Zenica, Burgić Dževad , Omerović Minela ,   Elementary School "Kiseljak 1", Kamber Dina ,   Faculty of Science, University of Sarajevo
Published: September 2021

Cooperative learning is a modern teaching strategy in which team work and cooperation become the most important activities of the entire teaching process. The quality of interaction between students and teacher, as main participants in teaching process, is important for successful application of cooperative learning. Beside faster and longer lasting knowledge acquiring, cooperative learning develops critical and creative thinking, communication and social skills and it strengthens self-confidence. Modern methods of teaching mathematics focus on didactical principle of conscious activity above other principles. This means students are major, active factors of mathematics teaching, and not only they participate in the process of teaching, but they also participate in the selection of methods of teaching. This enhances their motivation for work during classes. This means, what is learned through cooperative learning is better used in new situations, knowledge transfer is greater and new knowledge is acquired easier and lasts longer. Specific and abstract contents of mathematics lead to different ways of applying cooperative learning in this subject. That is why we chose this subject, i.e. to explore and point out the possibilities and ways of applying cooperative learning in mathematics.
FUNDAMENTALS OF APPLICATION FACTOR ANALYSIS IN EDUCATION AND REHABILITATION
Authors:   Faculty of Education and Rehabilitation Sciences, University of Tuzla, Mehmedinović Senad
Published: September 2021

Factor analysis is one of multivariate data processing methods, which studies the causal relationships of phenomena, that is, the cause of integration. In the introductory part of the paper, the basic definitions and interpretations regarding the factor analysis and the terms of multivariate methods, and some examples have been given in defining the manifest and latent, as explorative and confirmative examples. The justification for the application of factor analysis is elaborated in the main part of the paper with reference to the various authors who have dealt with this issue. Also, the paper presents the procedures of factor analysis, and presents tables and graphs showing the results necessary for interpretation. Given that for special education and rehabilitation a biopsychosocial approach is fundamental, factor analysis can be a powerful tool when studying interconnections of different phenomena. Its proper application by educatorsrehabilitators, who act to this problem, may help in understanding the causes of connections of phenomena, and as such it helps in the development of a treatment for the prevention, education and rehabilitation of persons with disabilities.
GAME THEORY IN THE ANALYSIS OF MONETARY AND FISCAL POLICY ON THE EXAMPLE OF REPUBLIC OF CROATIA
Authors:   University of Zagreb, Faculty of Economics and Business, master student of Economics, Bošnjak Krešimir , Perić Tunjo ,   University of Zagreb, Faculty of Economics and Business, Department for Mathematics
Published: September 2021

The paper explored the interaction of monetary and fiscal policy through game theory. In the first part of the paper it isin short presented theoretical basis of fiscal and monetary policy, and then explained the theoretical part of game theory also in short. After theoretical part, the analysis was conducted based on the collected data and then the results of the paper are presented. A function of payments for monetary and fiscal policy have been created on the basis of data inflation, unemployment rate, total liquidity and the rate of government spending in the Republic of Croatia. Multiple linear regression, which is processed using software solutions Eviews, derived parameters for independent variables. In this way, holders of monetary and fiscal policy can decide on quantities of independent variables, and based on that, determine their strategy. The obtained result, based on the functions of payments for monetary and fiscal policy, generated the matrix of payments. Solving the matrix of payments resulted with non-dominated solutions. For solving the problem, PROMETHEE method has been applied. Analysing the game by using the PROMETHEE method, it generated optimal solutions in terms of assumption when a greater impact on the economy, in this case on the inflation and unemployment, has the fiscal policy and in terms of assumption when a greater impact on the economy has monetary policy. As the optimal results we obtained only two strategies although the game has been repeated in many stages.
LIFE SKILLS OF YOUNG PEOPLE WITH DISABILITIES AND YOUTH WITHOUT DISABILITIES
Authors:   University of Tuzla, Faculty of Education and Rehabilitation Bosnia and Herzegovina, Husić-Đuzić Izeta , Tulumović Ševala ,   Elementary school "Mejdan", Tuzla, Bratovčić Vesna ,   University of Tuzla, Faculty of Education and Rehabilitation Bosnia and Herzegovina
Published: September 2021

The aim of this paper is to determine the differences in life skills of young people with and without disability in chronological age from 18-35 year-old in Tuzla Canton. The respondents sample consists of two sub-samples. First sub-sample contains 50 young people with disability, chronological age from 18-35 of both genders. Second sub-sample contained 50 young people without disability, chronological age from 18- 35 of both genders. Research data were analysed using method of parametric and non-parametric statistics. Frequencies, percentages and measures of central tendency have been calculated (arithmetic mean and standard deviation). P-values have been used for examining the difference between variables and variance analysis has been used for examining the importance of differences. The results show that there is a significant statistical difference between young people with and without disabilities in the of life skills assessed: job retention skills, skills to cope in danger. Based on the results obtained, it is recommended to start the program and training in early age which will make life easier to disabled persons and their families.
REAL CONVERGENCE OF BOSNIA AND HERZEGOVINA TOWARDS THE EUROPEAN UNION
Authors:   University of Zenica, Faculty of Economics, Bosnia and Herzegovina, Mahmutović Hasan , Merdić Alem ,   University of Zenica, Faculty of Economics, Bosnia and Herzegovina
Published: September 2021

The entire process of Bosnia and Herzegovina's path to European integration so far, is mostly limited to the problems of achieving political consensus, neglecting the essence and purpose of the integration process, which is primarily reflected in achieving the real convergence of Bosnia and Herzegovina towards the EU. The absence of real convergence, and adequate preparation in terms of competitiveness of the economy of Bosnia and Herzegovina for the EU membership, can cause negative effects of integration.Considering that there has not yet been written any paper that questions the lack of real convergence, primarily GDP p.c., and that a complete analysis of economic criteria is reduced to the Progress Reports of Bosnia and Herzegovina towards the EU, which summarize the fulfillment of the economic criteria of Bosnia and Herzegovina for the EU membership without concrete suggestions for improvement, this paper analyzes the real convergence of Bosnia and Herzegovina towards the European Union, observed through the income level p.c., prices and productivity of the labor force.The analysis showed that there is a sigma convergence of Bosnia and Herzegovina towards the EU in the movement of GDP p.c., which is reflected in the reduction of the coefficient of variation of the observed parameter in the period from 2000 to 2015 from 89.8% to 85.3%, which is a decrease in the coefficient of variation for 4 , 5 p.p. for 16 years.In the observed period there was an increase in the absolute GDP p.c. gap, which means that Bosnia and Herzegovina must increase the rate of economic growth in the coming period, in order to stop the relative decrease in the standard of living in relation to the EU.In addition, the analysis of sigma convergence has shown that there are sigma divergent trends in the movement of productivity and price level of Bosnia and Herzegovina in relation to productivity and price level at the EU level.It is expected that the price level in Bosnia and Herzegovina will increase in the coming period as a result of the activation of the Stabilization and Association Agreement and a higher degree of trade integration with the EU.
SELF-FASHIONING IN RENAISSANCE DUBROVNIK: MARIN DRŽIĆ VIDRA (1508-1567)
Authors:   Faculty of Philosophy, University in Niš, Republic of Serbia, Arsić Irena
Published: September 2021

Modern interpretation methods of the most important works of European Renaissance provide new opportunities in the interpretation of comedies of Dubrovnik writer Marin Držić. This especially applies to the theory of the new historicism, whose most important representative Stephen Greenblatt in his classic work Renaissance self-fashioning, provides an opportunity to examine Držić and his work according to this theory that deals withthe identity of the Renaissance creators, which was also the goal of this work. In this way new and more detailed analysis of Držić pastoral, farce and Plautuscomedy was opened, which will prove againthe classical quality and timeless value of the dramatic work of the greatest renaissance writer in our region.
POSSIBLE CALCULATOR ADDICTION IN STUDENTS WHILE PERFORMING SIMPLE CALCULUS OPERATIONS IN SOLVING MATHEMATICS PROBLEMS
Authors:   Department of Mathematics, Faculty of Sciences, University of Tuzla, Bosnia and Herzegovina, Rešić Sead , Omerović Maid ,   Department of Mathematics, Faculty of Sciences, University of Tuzla, Bosnia and Herzegovina, Baždalić Tarik ,   Faculty of Education Travnik, Bosnia and Herzegovina, Osmić Amila ,   Mixed secondary construction school Tuzla, Bosnia and Herzegovina
Published: September 2021

Contemporary learning processes in schools and universities could not be imagined without the use of computers and calculators. Naturally, all is good if they are used in order to acquire new knowledge or solve problems from expert subjects in technical schools, which demand large quantity of simple mathematical operations. However, what if frequent use of calculators, either pocket or those installed on every home and school computer, becomes an addiction in students who begin using them while calculating simple mathematical operations, such as multiplying or adding and detracting one-digit numbers or numbers smaller than 20, when they should know this by heart? We arrived at this hypothesis during knowledge tests for students after regular demonstrations and elaborations of Mathematics subject matter. In order to confirm or deny this hypothesis, generic/developmental method, that is, survey was used as one of research techniques (Selimović, 2013., p. 104). The survey was conducted in March during academic 2016/2017 and the sample consisted of 59 students in 2nd grade of Grammar School Tešanj.
PROPERTY RELATIONS OF MARITAL PARTNERS THROUGH THE HISTORY OF BOSNIA AND HERZEGOVINA
Authors:   Faculty of Law Tuzla, University of Tuzla, Krešić Boris , Halilović Ervina ,   Faculty of Law Tuzla, University of Tuzla
Published: September 2021

The institutes of contemporary family law are rooted in Roman law, including the property relations of marital partners. From the historical perspective, the property-legal relations of marital partners in Bosnia and Herzegovina (BiH) were subject to religious regulations and the rules of the General Civil Code and Family Law of the Socialist Republic of Bosnia and Herzegovina. The article analyzes the solutions applied during the Roman, the Ottoman, and the AustroHungarian rule as well as the solutions included in the currently valid Basic Law on Marriage and Family Laws in BiH. The authors focus on the development of family law in terms of property relations of marital partners and provide historical-legal overview of the development of family law from the absolute power of pater familias to the full equality of marital partners.