bluuebunny/crossref_metadata_2025 huggingface dataset:
The Sankey Diagram and Citation Trend Analysis Used to Display JMIR mHealth and uHealth Articles That Are Worth Reading: Bibliometric Analysis (Preprint)
Authors: Ho Sam Yu-Chieh , Chien Tsair-wei , Huang Chien-Cheng , Tsai Kang-Ting
Published: September 2022

BACKGROUND

It has been common in bibliographical studies to apply the citation trend of research to journal articles. There is no such enhanced temporal bar graph (TBG) to provide a better understanding of articles that are most worth reading. The Sankey-type TBG for highlighting articles worth reading is needed.

OBJECTIVE

The purpose of this article is to (1) describe the characteristics of articles in JMIR mHealth and uHealth (JMIRMU), (2) illustrate which JMIRMU articles are most worthwhile to read, and (3) compare the differences in article types in terms of citation trends between China and the United States.

METHODS

On July 11, 2022, we obtained 2,202 abstracts indexed in the Web of Science core collection (WoSCC) by searching for the keywords "JMIR mHealth and uHealth" (Journal) and the time span between 2013 and 2021. Metadata, including author names, research institutes, article identifiers (PMIDs), countries, and article citations, were collected over time. A Newton‒Raphson Iteration Method (NRIM) and a growth/share matrix (GSM) were used to display the burst spot and growth trend. The first and corresponding authors of articles were evaluated and displayed for countries/regions on choropleth maps. Sankey-type TPBs were applied to display (1) the characteristics of articles in JMIRMU, (2) JMIRMU articles that are the most worthwhile for readers, and (3) differences in article types between Chinese and American articles based on citation trends in recent years.

RESULTS

The top two productive entities were years in 2020(n=566) and 2019(420), the US(1251) and China(341), the University Sydney(Australia)(48), and Seoul National University(South Korea)(42) in research institutes, Ura-Vito Albrecht (Germany)(15) and Melvyn Zhang(Singapore)(10) in authors. Mobile phone (380) and mHealth (755) were the most common author-defined keywords in 2016 and 2021. PMID=29650506 and 30470676 are the most worthy-reading articles, with burst strengths of 5.83 and 6.46, respectively, against the two most-cited articles of 25760773 and 26537656. There was no difference in proportional counts of growth increasing articles between China and the US.

CONCLUSIONS

Using the Sankey-type TBG and trend analysis, we illustrated how to select articles that are most worth reading for authors. It is recommended for future bibliometric analysis and is not limited to citation analyses of articles in JMIRMU, as we did in this study.
A Systematic Review of Ontologies applied in Clinical Decision Support System Rules (Preprint)
Authors: Jing Xia , Min Hua , Gong Yang , Biondich Paul , Robinson David , Law Timothy , Nohr Christian , Faxvaag Arild , Rennert Lior , Hubig Nina , Gimbel Ronald
Published: September 2022

BACKGROUND

Clinical decision support systems (CDSS) play a critical role in the quality and safety of healthcare delivery. Although CDSS rules direct CDSS behavior, CDSS rules have not been routinely shared and reused.

OBJECTIVE

Ontology has the potential to promote the reusing of CDSS rules. Therefore, we systematically screened literature to elaborate on the current status of ontology applied in CDSS rules, e.g., rule management (uses the captured CDSS rule usage data and users’ feedback data to customize CDSS services to be more accurate) and maintenance (updates CDSS rules). We aim to delineate the frontlines of ontologies applied in CDSS rules via this systematic literature review.

METHODS

The literature search was focused on ontology, clinical decision support, and rules in PubMed, the Association for Computing Machinery (ACM) Digital Library, and the Nursing & Allied Health Database. Grounded theory and PRISMA 2020 guidelines were followed. One author started the screening and literature analysis, and two validated the processes and results. Inclusion and exclusion criteria were developed and refined iteratively.

RESULTS

Among the 81 included publications, CDSS were mainly applied to managing chronic conditions, alerts for medication prescriptions, reminders for immunizations and preventive services, diagnoses, and treatment recommendations. The CDSS rules were presented in Semantic Web Rule Language, Jess, or Jena formats. Despite ontologies being used to supply medical knowledge, CDSS rules, and terminologies, ontologies have not been used in CDSS rule management or facilitate the reusing of CDSS rules.

CONCLUSIONS

Ontologies have been used to organize and represent medical knowledge and controlled vocabularies that contribute to CDSS and the content of CDSS rules. So far, there is a lack of reusing CDSS rules. More efforts are needed to improve the reusability and interoperability of CDSS rules. This paper delineated the ontologies, enabling Semantic Web technology, despite inadequate, and their applications in CDSS rules.
Effectiveness of Digital Mental Health Tools to Reduce Depressive and Anxiety Symptoms in Low- and Middle-Income Countries: Systematic Review and Meta-analysis (Preprint)
Authors: Kim Jiyeong , Aryee Lois M D , Bang Heejung , Prajogo Steffi , Choi Yong K , Hoch Jeffrey S , Prado Elizabeth L
Published: September 2022

BACKGROUND

Depression and anxiety contribute to an estimated 74.6 million years of life with disability, and 80% of this burden occurs in low- and middle-income countries (LMICs), where there is a large gap in care.

OBJECTIVE

We aimed to systematically synthesize available evidence and quantify the effectiveness of digital mental health interventions in reducing depression and anxiety in LMICs.

METHODS

In this systematic review and meta-analysis, we searched PubMed, Embase, and Cochrane databases from the inception date to February 2022. We included randomized controlled trials conducted in LMICs that compared groups that received digital health interventions with controls (active control, treatment as usual, or no intervention) on depression or anxiety symptoms. Two reviewers independently extracted summary data reported in the papers and performed study quality assessments. The outcomes were postintervention measures of depression or anxiety symptoms (Hedges g). We calculated the pooled effect size weighted by inverse variance.

RESULTS

Among 11,196 retrieved records, we included 80 studies in the meta-analysis (12,070 participants n=6052, 50.14% in the intervention group and n=6018, 49.85% in the control group) and 96 studies in the systematic review. The pooled effect sizes were −0.61 (95% CI −0.78 to −0.44; n=67 comparisons) for depression and −0.73 (95% CI −0.93 to −0.53; n=65 comparisons) for anxiety, indicating that digital health intervention groups had lower postintervention depression and anxiety symptoms compared with controls. Although heterogeneity was considerable (I2=0.94 for depression and 0.95 for anxiety), we found notable sources of variability between the studies, including intervention content, depression or anxiety symptom severity, control type, and age. Grading of Recommendations, Assessments, Development, and Evaluation showed that the evidence quality was overall high.

CONCLUSIONS

Digital mental health tools are moderately to highly effective in reducing depression and anxiety symptoms in LMICs. Thus, they could be effective options to close the gap in depression and anxiety care in LMICs, where the usual mental health care is minimal.

CLINICALTRIAL

PROSPERO CRD42021289709; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=289709
Application of Molecular spectroscopy and chemometrics for authentication and quality control of tea (Camellia sinensis L.): a review
Authors: Arifah Mitsalina Fildzah , Hastuti Agustina A.M.B. , Rohman Abdul
Published: September 2022

Tea, derived from Camellia sinensis L., is considered as the most popular beverages in the world. The quality of teas may vary depending on harvesting location and geographical origins, thus the traceability of teas according to their origins is very essential to assure tea’s quality. Due to economic reasons, high quality tea products may be added with foreign materials or adulterated with low quality ones, as a consequence, some analytical methods have been proposed and developed to quality control of tea. During the recent years, the application of molecular spectroscopic techniques (UV-Vis, Fluorescence, Near Infrared, Mid Infrared, Raman) in combination with multivariate data analysis has emerged as rapid and reliable analytical tool in the quality control of food, including food authentication. The objective of this review is to update the application of molecular spectroscopy (UV-Vis, fluorescence, infrared and Raman) for the quality control and authentication of tea products either geographical origins issue or detection of potential adulterants. The variables obtained during molecular spectral measurement involve hundreds or thousands of data, which make data analysis rather complex. Fortunately, the specific chemometrics tools can solve the problems arising from big data coming from analyte signals, spectral interferences and overlapping peaks. This review paper provides an overview of the recently developed approaches and latest research carried out in molecular spectroscopic techniques in combination with chemometrics for the quality control and for authentication of teas
"Does the bullet deliver where the ballot has failed?"
Authors: Denndörfer Lisa , Strauer Viktoria , Thebes Sonja
Published: September 2022

Political assassinations in Pakistan have been a systematic challenge ever since the country’s independence from Great Britain in 1947. While state actors formed unlikely alliances with Western Powers in the aftermaths of the Afghan War and during the War on Terror, non-state actors, like Islamist jihadi groups, used the country for domestic and foreign terrorist attacks and to spread violence, thus demonstrating the conflict between the different players in Pakistan. When the country was transformed into a young democracy in 2007/2008, the number of assassinations did not decrease, but rather increased by ninefold.

This article analyses the case of political assassinations in Pakistan and attempts to explain the prevalence of political assassinations in the country. First, the overall pattern and seriousness of political murders is identified with help from a self-created dataset. Then said pattern is explained by arguing that the main explanatory factors at play in Pakistan are socioeconomic conditions, social conflict, elections, military and religion, sectarianism and blasphemy laws. Lastly, a brief discussion of long- and short-term measures is done.
DRAGOLJUB JOVANOVIĆ – DRUŠTVENO ANGAŽOVANI INTELEKTUALAC U TEŠKIM VREMENIMA
Authors: Andjelkovic Petar , Milivojevic Snezana
Published: September 2022

U meandrima srpske istorije, često su se dešavali diskontinuiteti, koji su ideološki bili usmeravani, sa neshvatljivih zabluda i stranputica i koji su neretko bili tragični. U tim „vetrovima istorije”, mnogi značajni intelektualci koji su ukazivali na te zablude i moguće nedaće, trpeli su velike posledice (lične i naučne), potiskivani su iz kolektivnog sećanja, zaboravljeni a neki su proglašavani i državnim neprijateljima, kao što je to bio slučaj sa Dragoljubom Jovanovićem. Za adekvatan odgovor na izazove koje istorijsko vreme, stavlja pred narod, najodgovornija je elita svakog naroda, čiji je zadatak-poziv da zna i da vidi najbolje. Drugačije rečeno, jedan narod spreman je za izazove vremena u onoj meri u kojoj je spremna njegova elita, pa je stoga neophodno traganje za odgovorom na pitanje šta je mera pravog društvenog angažovanja intelektulaca. Kada je pronađemo, onda imamo obrazac, lik koji treba slediti. Da li Dragoljub Jovanović može biti mera pravog društveno angažovanog intelektualca? Ovaj ogled nastoji da dâ odgovor na to pitanje.
POLITIČKA FILOZOFIJA ORDOLIBERALIZMA: FENOMEN SOCIJALNO-TRŽIŠNE PRIVREDE
Authors: Vulic Milos
Published: September 2022

U ovom radu bavićemo se ordoliberalnom političkom filozofijom i socijalno- tržišnom privredom, kao njenim ključnim fenomenom. Cilj nam je da pokušamo da pokažemo razvojni put pojma, njegovu inicijalnu percepciju, ali i njegovu kasniju recepciju. U prvom delu rada se analiziraju izvori socijalno-tržišne privrede, od kojih se kao osnovni izvor izdvaja hrišćanska socijalna doktrina, koja je rođena kao reakcija na ekonomsko-političke probleme. Posebna pažnja posvećena je papskim enciklikama, koje čine osnov hrišćansko-demokratske ideologije. Drugi deo je posvećen razvoju socijalno tržišne privrede. U njemu se bavimo nastankom Frajburške škole i mišlju njenih glavnih predstavnika, koji će u liberalnu tradiciju uvesti koncept poretka, zbog čega će ostati poznati kao pripadnici ordoliberalizama. Treći deo analizira sistematizaciju socijalno-tržišne privrede, sa posebnim osvrtom na odnos filozofija ordoliberalizma i neoliberalizma, u smislu njihovih sličnosti i razlika. U tom delu se bavimo i međunarodnim kontekstom ove političke filozofije kroz formiranje Društva Mont Pelerin. U poslednjem delu rada razmatra se recepcija socijalno-tržišne privrede, u nemačkom i evropskom kontekstu sa zaključkom da u vremenima ponovnih globalnih kriza, vrednosti koje ordoliberalna politička filozofija i fenomen socijalno-tržišne privrede nose sa sobom mogu ponovo doprineti odgovornosti među ekonomskim i političkim akterima.
POVRATAK RUŽIČASTE PLIME I ZAOKRET ULEVO: LA NUEVA IZQUIERDA U LATINSKOJ AMERICI
Authors: Krstic Zoran
Published: September 2022

Predmet proučavanja u ovom radu jeste povratak i uspon nove levice na izborima održanim u prethodne četiri godine u Latinskoj Americi. Fokus istraživanja usmeren je na uzroke i posledice povratka ružičaste plime i njene osnovne karakteristike. Osnovni cilj ovog rada je da se objektivno sagledaju problemi i poteškoće sa kojima se suočavaju države regiona u kontekstu ciklične smene levičarskih i desničarskih politika. Posebna pažnja u radu posvećena je analizi faktora koji su pomagali ili ometali institucionalizaciju levičarskih politika. Deo rada fokusiran je na analizu odnosa između novih društvenih pokreta i države, kao i na ekonomsku zavisnost i eksploataciju prirodnih resursa. Povratak levičarskog talasa jeste reakcija na povećane ekonomske i socijalne nejednakosti koje su dovele do niza protesta i nemira i pojave različitih društvenih pokreta. Problem u Latinskoj Americi je u tome što se taj region suočava ne samo sa nerazvijenošću već i sa strukturalnom krizom kredibiliteta u demokratske i političke sisteme. U radu je korišćen istorijsko-deskriptivni i kontekstualni pristup u analizi fenomena „ružičasta plimaˮ.
ON ROUGH $I^*$ AND $I^K$-CONVERGENCE OF SEQUENCES IN NORMED LINEAR SPACES
Authors: Paul Anirban
Published: September 2022

In this paper, we have introduced first the notion of rough $I^*$-convergence in a normed linear space as an extension work of rough $I$-convergence and then rough $I^K$-convergence in more general way. Then we have studied some properties on these two newly introduced ideas. We also examined the relationship between rough $I$-convergence with both of rough $I^*$-convergence and rough $I^K$-convergence.
Identidad profesional, incidentes críticos y estrategias de afrontamiento en el profesorado de matronería
Authors: Altamirano-Droguett J. , Nail-Kröyer Ó. , Monereo-Font C. , Salazar-Llanos Y.
Published: September 2022

Introducción: La identidad profesional docente está conformada por las dimensiones cognitiva, psicomotriz y afectiva que surgen de la enseñanza. Los incidentes críticos en escenarios universitarios permiten un cambio radical de estas representaciones cuando la reflexión es la estrategia de afrontamiento. Nuestro estudio aporta nuevos conocimientos a la docencia de matronería.
Objetivos: Establecer la relación entre las dimensiones identitarias del profesorado de matronería con las estrategias de afrontamiento ante incidentes críticos en contextos educativos, así como identificar las estrategias utilizadas por el grupo de docentes para cada incidente crítico.
Método: Estudio transversal y correlacional, muestreo no probabilístico por conveniencia. Participaron 231 docentes de 21 universidades chilenas. Se aplicó el cuestionario Identidad profesional de matronas/es docentes y estrategias de afrontamiento ante incidentes críticos. Las pruebas estadísticas fueron de tipo descriptivas e inferenciales.
Resultados: Se obtuvo una relación estadísticamente significativa entre las dimensiones identitarias y las estrategias de afrontamiento ante sucesos inesperados. Los abordajes reflexivos fueron determinantes en el cuerpo académico en estudio.
Discusión y Conclusiones: Los componentes identitarios varían en función del tipo de afrontamiento de cada participante. La posición académica de investigación de la dimensión cognitiva denota mayor preocupación por su desarrollo incipiente. La postura reflexiva prepondera en el grupo de docentes; no obstante, los incidentes críticos son resueltos de manera temporal, con la posibilidad de reproducirse nuevamente. Este estudio sustenta la necesidad de ofrecer programas de manejo de incidentes críticos en escenarios educativos y en metodologías de investigación que permitan una reconceptualización del ser docente universitario.
La Administración Pública: una ciencia postnormal y multiparadigma
Authors: González José Juan Sánchez
Published: September 2022

En el estudio del campo disciplinario hay una corriente teórica que a partir de las teorías de Kuhn (1962) de su desarrollo teórico de los paradigmas, la ciencia normal y las revoluciones científicas, sostiene tres axiomas sujetos a discusión: primero, la Administración Pública es una ciencia postnormal -ya que la ciencia normal son las ciencias duras y exactas- debido a que su ontología y epistemología no se aplica a los planteamientos de un paradigma de una ciencia normal (Ricucci, 2008); la segunda, en la Administración Pública existen al menos seis paradigmas predominantes -gerencial, político, judicial, ética, histórica e integrado- en el campo de estudio de los Estados Unidos lo que provoca que hay predominancia de “paradigmas”, ello permite debates, importaciones y exportaciones entre paradigmas; tercero, se sostiene que la Administración Pública es una ciencia “multiparadigma” debido a que existen diversos “paradigmas” en el campo disciplinario que se encuentran en disputa teórica, en cuatro formas: (1) inconmensurabilidad; (2) integración; (3) puentes (donde existen zonas de transición); y (4) cruzando contrastes (donde existen conexiones). En conclusión, la Administración Pública moderna es una “ciencia postnormal” debido a que se trata de una ciencia social y es una “ciencia multiparadigma” debido a que existen varios paradigmas prevalecientes en el campo disciplinario.
Efectividad de intervenciones psicológicas en mujeres con trastorno por atracón: una revisión sistemática/Effectiveness of psychological interventions in women with binge eating disorder: a systematic review
Authors: Valdez Aguilar Mariana , Vázquez-Arévalo Rosalia , Mancilla-Diaz Juan Manuel , Beas Jara María Del Carmen
Published: September 2022

Objetivo: Examinar la efectividad, contenido, tipos de intervención y calidad de los tratamientos psicológicos de trastorno por atracón (TPA) en mujeres, que se han realizado en los últimos 20 años. Método: La revisión sistemática se realizó basada en la guía PRISMA y fue llevada acabo de Septiembre de 2018 a Junio de 2020 en las bases de datos: Medline, Scopus, Sciencedirect, Scielo, Redalyc y LILACS. Resultados: Se identificaron 206 artículos potencialmente relevantes, se seleccionó 15 que cumplían los criterios de inclusión. En el análisis de resultados se identificó que la mayoría de los estudios tuvo como objetivo probar la efectividad de las intervenciones. Los enfoques clínicos más utilizados fue la Terapia Cognitivo Conductual, la Terapia Dialéctica Conductual, la Terapia de Imagen Coporal y el Psicoanálisis. Los cuestionarios más utilizados para medir el TPA fueron el Eating Disorder Examination, la entrevista clínica basada en el DSM y la Escala de Atracón (BES). Discusión:  Se observa retos en el trabajo multidisciplinario, además de resaltar la importancia del compromiso colaborativo con el paciente. Se plantea la necesidad de mayores estudios que consoliden y profundicen en la evaluación y tratamiento temprano del trastorno, así como ahondar en el enfoque emocional.
Relación entre aprecio corporal, alimentación intuitiva y gratitud: Una revisión/Relationship between body appreciation, intuitive eating and gratitude: A review
Authors: Robledo González Brenda , Escoto-Ponce de Leon María Del Consuelo , Cervantes Luna Brenda Sarahi , García Lozano Rodolfo Zolá
Published: September 2022

Resumen En este estudio se realizó una revisión de la literatura para examinar el aprecio corporal con relación a la alimentación intuitiva y la gratitud en mujeres y hombres, adolescentes y adultos. Los artículos se identificaron a través de PubMed, ProQuest Central, EBSCO y Web of Science. Treinta y un estudios transversales y uno longitudinal cumplieron con los criterios de elegibilidad y mayormente se realizaron en Norteamérica. La relación entre gratitud, aprecio corporal y alimentación intuitiva fue positiva y significativa tanto en hombres como en mujeres, adolescentes y adultos. Además, la gratitud predice el aprecio corporal, el cual a su vez media la relación entre gratitud y alimentación intuitiva, en mujeres. Este estudio aportó información valiosa sobre la importancia de la actitud agradecida para desarrollar y/o mantener una imagen corporal positiva y hábitos alimentarios adaptativos. Este hallazgo es importante, debido a que la gratitud puede ser modificada por medio de intervenciones terapéuticas.AbstractIn this study, we conducted a literature review to examine body appreciation in relation to intuitive eating and gratitude in women and men, adolescents and adults. Papers were identified through PubMed, ProQuest Central, EBSCO, and Web of Science. Thirty-one cross-sectional and one longitudinal study met the eligibility criteria and were mostly conducted in North America. The relationship between gratitude, body appreciation and intuitive eating was positive and significant in both men and women, adolescents and adults. Furthermore, gratitude predicts body appreciation, which in turn, mediates the relationship between gratitude and intuitive eating, in women. This study provided valuable information on the importance of a grateful attitude in the developing and/or maintaining a positive body image and adaptive eating habits. This finding is important, because gratitude can be modified through therapeutic interventions.
IMPACT ANALYSIS OF URBAN FREIGHT TRIPS GENERATED FROM WHOLESALE MARKET, AHMEDABAD
Authors: Chaudhari Jignesh , Shukla Rena , Patel Chetan
Published: September 2022

Freight transport plays an important role in meeting the domestic needs of the city's inhabitants. But when freight vehicles come into contact with city traffic, it has a negative impact on urban routes, such as extra traffic congestion, noise pollution, air pollution, etc. The aim of the study is to assess the impact of freight transport on the overall traffic of the city. A case study of the wholesale market of Ahmedabad has been considered as a study area. The freight trip models based on the trips attracted and produced by the market are developed on the basis of data collected from establishment surveys and freight vehicle driver surveys. Both the models developed in this study, FTA (Freight Trip Attraction) and FTP (Freight Trip Production), have R Square values of 0.799 and 0.715, respectively. The volume of freight vehicles contributing to the overall traffic flow is also measured by the traffic volume study. Through the data analysis and identification of the impact of freight transportation on city traffic, remedial measures are discussed to reduce the impact of freight transportation.
Quantum capacity and codes for the bosonic loss-dephasing channel
Authors: Leviant Peter , Xu Qian , Jiang Liang , Rosenblum Serge
Published: September 2022

Bosonic qubits encoded in continuous-variable systems provide a promising alternative to two-level qubits for quantum computation and communication. So far, photon loss has been the dominant source of errors in bosonic qubits, but the significant reduction of photon loss in recent bosonic qubit experiments suggests that dephasing errors should also be considered. However, a detailed understanding of the combined photon loss and dephasing channel is lacking. Here, we show that, unlike its constituent parts, the combined loss-dephasing channel is non-degradable, pointing towards a richer structure of this channel. We provide bounds for the capacity of the loss-dephasing channel and use numerical optimization to find optimal single-mode codes for a wide range of error rates.
ON THE CALCULATIONS FOR THE STABILITY OF BEAMS, FRAMES, AND CYLINDRICAL SHELLS IN THE ELASTO-PLASTIC STAGE
Authors: Manuylov Gaik , Kosytsyn Sergey , Begichev Maxim
Published: September 2022

The problems of stability of some beams, Π-shaped frames and cylindrical shells with the elasto-plastic material are considered. The possibility of modeling bars using finite elements of various types is studied. Plate elements and even one-dimensional beam finite elements can be used for modelling compressed rods with geometric and physical nonlinearity. For the problem of stability of a circular cylindrical shell is given the comparison of the authors' results obtained using the FEM with the experimental results of V.G. Sazonov and the calculations of A.V. Karmishin.
Clinical Trials of Solid Tumor Drugs Approved in Europe: Evidence-Based-Medicine
Authors: Aseel  Bin Sawad  , Amin  Aissaoui  , Najah Aissaoui  , Ahmed Bin Sawad  , Fatema Turkistani
Published: September 2022

The Response Evaluation Criteria in Solid Tumors (RECIST) were introduced to determine response to therapy by evaluation  of  change from baseline  while  on the treatment  of  the solid  tumor. These criteria  are used mainly in clinical trials where tumor objective response (tumor shrinkage) or disease progression is the primary endpoint. RECIST is widely  used by academic institutions, cooperative groups, and industry for oncology clinical  trials. Regulatory authorities use RECIST as an appropriate  guideline for  risk-benefit  assessments of  oncology  drugs. This  study aimed  to assess the impact  on pivotal  clinical trial  designs  due  to  adopting  the  RECIST  for  assessing the  risk-benefit  ratio  for  oncology  drugs approved  in  Europe  for treatment of solid tumors (2000–2019). The Summary of Product Characteristics for all oncology drugs was reviewed to identify the  pivotal  clinical  trials.  Results:  There  were  78  pivotal  clinical  trials  for  38  oncology  drugs approved, by the  European Medicines Agency (EMA), for treatment  of solid tumors. Open-label randomized controlled trials (RCTs) account for 62.82% of the pivotal clinical trials compared to 37.18% blinded RCTs. A total of 6,721 patients (average=1,120) participated in 78 pivotal clinical trials. Around sixty-three percent (4,211 out of 6,721) of patients participated in blinded RCTs, and 37.34% (2,510 out of 6,721) of patients participated in open-label RCTs. Conclusion: Less restrictive rules for oncology drugs approval were applied by the regulatory  agency. Over  19 years, EMA had approved oncology  drugs based on open-label  trials,  especially when an oncology drug was compared to an active comparator, with results of few or no clinical improvement over existing therapy. The approval process of oncology drugs should be supported by clear evidence about the clinical effects of the new oncology drugs compared to the existing effective oncology therapies using clinical trial designs that are methodologically rigorous.
On Distinctiveness of the Arabic Poetic Canon of the 13th to 18th Centuries
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Kudelin Alexander B. ,   Lomonosov Moscow State University
Published: September 2022

The long period of the 13th to 18th centuries in Arab history has hardly received exhaustive treatment in international scholarship. To account for this deficiency, one might note that while in recent decades there has been much accomplished in the field of Oriental studies dealing with elucidating of Arabic poetry from antiquity to the 10th–12th centuries, Arabic literature of the 13th–18th centuries is still lacking attention prompted by advanced interpreting practices. The corresponding studies tend to overlook many achievements of international Medieval scholarship including those engaged with traditionalistic type of artistic mindset and with principles of canonfollowing creativeness. Also, late medieval Arabic works are often considered out of their proper context; namely, they are measured against theoretical and literary notions drawn from European literatures of Modern and Late Modern periods. In aiming to offer a corrective to previous interpretive models, this article reconsiders the intensive development of figurative speech techniques in classical Arabic poetry going back to the 2nd / 8th century. Special attention is paid to figurative techniques addressing visual perception and exhibiting the growing importance of the graphic side of writing. The article holds that late medieval Arabic literature is continuously aware of ancient heritage, given the importance of poetics of reminiscences, which back then used to inform such generic modes as takhmīs and tashṭīr. The article also regards works of Ṣafī al-Dīn al-Ḥillī (d. c. 749/1348), who is among the most renowned and noted Arab authors of the 8th / 13th–14th centuries.
“Author’s Confessionˮ by N.V. Gogol: Problems of Commenting
Authors:   Herzen University, Balakshina Julia V.
Published: September 2022

The article addresses the issues of commenting on N.V. Gogol’s prose of the 1840s. The focus is on “Author’s Confession.ˮ Unfinished and unpublished during the writer’s lifetime, the text was later entitled by S.P. Shevyryov. A number of common problems in how today’s readership comprehends the Russian classics are pointed out, more specifically, the changes in the cultural horizon and the renunciation of universalizing interpretations. The article highlights specific features of Gogol’s late prose, defined by a turning-point in his religious belief and creative work, namely aiming at a direct dialogue with the reader, strengthening the elements of preaching and confession, self-commenting on one’s own texts, emphasizing the symbolic and mysterious nature of the word. The author suggests assumptions on how these features can be conveyed using the commentary apparatus and offers a detailed analysis of two commentary problems, based on “Author’s Confession.ˮ Firstly, the article discusses how fiction elements are introduced into the autodocumentary text; secondly, it shows how the text correlates with the writer’s epistolary heritage. Conclusions demonstrate the specific genre nature of “Author’s Confession.ˮ The article outlines the approaches and techniques of transforming an epistolary text into a public one. These observations and conclusions can be used in preparing “Author’s Confessionˮ for publication as part of the complete works of N.V. Gogol.
THE ANALYSIS LANDSLIDES POTENTIAL DUE TO CHANGES OF LAND-USE IN MIU WATERSHED
Authors: Tamrin Izza Nadrata
Published: September 2022

This study aims to determine the magnitude of land-use change in the Miu watershed and to determine the relation between slope and soil type to erosions. The method used to predict the rate of erosion is the Universal Soil Loss Equation (USLE) in 2005, 2010, and 2016 with the help of the Geographic Information System (GIS). This study uses data on rainfall, slope, soil type, land use, and conservation and crop management factors which are then entered into the USLE equation. From this equation, the actual erosion rate in 2005 was 2,634,104.25 tons / year, 2010 was 3,285,025.34 tons / year, and 2016 was 1,856,140.79 tons / year. The average actual erosion in 2005, 2010, and 2016 was 2,591,756.79 tons/year, which is classified as minor erosion. The landslide-prone area based on the lowest slope of 5.50% is equivalent to an area of ​​36 km2, for the medium it is 34.81% equivalent to an area of ​​228 km2, and a height of 59.69% covering an area of ​​391 km2 where very steep slopes dominate this river basin. The effect of significant land-use change affects the rate of erosion when there is a high intensity of rain on a steep slope so the potential for erosions in the area.
Auditor independence in post-reform China: A neo-Durkheimian approach
Authors: Han Wenqi , Cull Michelle
Published: September 2022

This study builds on the work of Durkheim (1915) by applying a neo-Durkheimian theoretical framework to audit failure in China following the implementation of economic reform and international auditing standards to highlight how embedded cultural norms, such as guanxi (a social network system involving the mutually beneficial and reciprocal exchange of personalised favours), limit adaptation and influence auditor independence. Specifically, this study adopts the grid-group dimensions proposed by Douglas (2003) to assist in understanding how Chinese auditors interpret their social relations based on cultural beliefs and overlaid them with characteristics of Chinese culture to demonstrate the influence of guanxi. The study is based on publicly available data focusing on the financial scandals of Yin Guang Xia (YGX) and Yunnan Green Land Biological Technology (Green Land) in China. We argue that Chinese auditing failure occurred because of socially embedded cultural values which limited thought processes and prevented adherence to formal international auditing standards. Policymakers and regulators must consider emerging economies’ unique cultural environments when introducing economic reform. Different cultural contexts call for different interventions by a range of stakeholders to improve audit independence. The neo-Durkheimian (NDT) theoretical framework used in this study may be extended to examine auditing practices in other emerging economies across a range of cultures, and may also be relevant to other areas of professional practice
Connected Alone
Authors: Arja Anneli Kastinen
Published: September 2022

This exposition examines the possibilities and problems of using the elements of ancient musical culture for producing new music. It contains eleven video clips and associated texts explaining my artistic research on the Karelian kantele improvisation of the 19th century and earlier, which the kantele players called "soittaa omaa mahtia" ("playing their own power"). The word "mahti" ("power") means inner strength and knowledge. In this article, I call this particular music inner power improvisation.
In addition, the article includes two case studies that exemplify the use of tradition and its philosophy as tools in creativity education. I address the question of whether I can surpass the challenges of understanding a musical culture from a different time era and of an entirely different society than my own. Is it possible to receive an insider view through artistic research, by learning to make music according to the information found in the archives, historical texts, and folk music research? How do I perform responsible research and introduce my conclusions and musical interpretations when there is not enough reliable information about the original tradition?
Unified Physics and Cosmology: the Theory of Everything
Authors: Waugh Subhajit
Published: September 2022

Copernicus broke with 1300 years of tradition, and revolutionized
science by moving from earth-centric to sun-centric view. But, moving
the viewpoint to the true center of our expanding universe explains the
origin and true nature of time itself. From this God’s view, Relativity
and Quantum Mechanics are two sides of the same coin.

Relativity is inside the light cone phenomena (since nothing can travel
faster than light), while Quantum Mechanics is outside the light cone
phenomena (allowing instant communications in quantum
entanglement experiments). This recent paper [Quantum principle
of relativity; Andrzej Dragan, Artur Ekert, New. J. Phys. 22 (2020)
033098] has shown that every exotic Quantum effect like
superposition, entanglement, probabilistic behavior, multiple paths etc.
can be explained just by allowing superluminal possibility. The
inside the light cone phenomena and the outside the light
cone phenomena together span the entire region within the space and
time axes. Only in unison they complete the entire picture.

Both are dictated just by the scale (i.e. whether we use classical/human
scale or sub-atomic scale). We failed to realize that the same spacetime
is getting split into space like and time like regions
based on size scale. And the reason behind this is not the
magical (?) speed of light. That would have turned both
relativity and quantum mechanics into mere branches of electromagnetism.
The true reason is much deeper and at a very fundamental level of our
universe. It turns out that the c is the radial
expansion velocity of our universe.

But why does the transition from Relativity to Quantum Mechanics happens
with decreasing size scale? That’s because, this is what is happens to
spatial and temporal dimensions at different scales:

3+1 (Classical regime) <=>  2+2 (Compton regime)
<=> 1+3 (Planck regime).

From the center of universe viewpoint, simultaneity is absolute (as
demanded by Sagnac effect), and there is indeed absolute universal time
(as demanded by quantum mechanics). From our viewpoint (located at an
awkward position in the universe), locality is absolute, and velocity c
is the upper limit, and remains constant for every observer. This turns
(our) space and time into inseparable twins, and makes (our) time a
relative concept. This solves the time problem which had
so stubbornly resisted the reconciliation of Quantum Mechanics and
General Relativity.

General Relativity makes things a bit tricky since it involves curvature
(warping) of spacetime, but it does not become incompatible
with Quantum Mechanics. The only difference between the warped spacetime
of General Relativity, and the flat spacetime of Special Relativity is
very similar to the difference between a stretched rubber membrane, with
and without a metal ball placed on it. General Relativity and Quantum
Mechanics are the two pillars of modern Science. Reconciliation of the
two greatest theories of physics leads us to Theory of
Everything.
Offspring plumage colouration as a condition-dependent signal in the blue tit
Authors: García-Campa Jorge , Müller Wendt , Morales Judith
Published: September 2022

In many species, offspring display conspicuous adult-like colouration
already early in life, even though they might be very vulnerable to
predation at this stage. Yet, the signalling function of adult-like
traits in nestlings has been little explored to date. Here, we
investigated whether the yellow breast plumage of blue tit (Cyanistes
caeruleus) nestlings shows patterns of condition-dependence and hence
signals individual quality, as has been described for adult birds.
During three consecutive breeding seasons, we therefore explored the
association between nestling body mass and three colour components of
the yellow breast plumage (i.e., UV chroma, carotenoid chroma and total
brightness), considering both within and among nest effects. Carotenoid
chroma was not affected by body mass. However, UV chroma and total
brightness showed an among-nest effect of body mass, suggesting that
they might signal aspects of genetic quality or parental rearing
capacity. Interestingly, we also found a within-nest effect of body mass
on total brightness, suggesting that this is a good candidate for a
condition-dependent signal within the family. Thus, other family members
could rely on brightness to adjust their behavioural strategies, such as
feeding behaviour in parents. Our study thus reveals that certain colour
components of the yellow breast plumage signal different aspects of
offspring quality and suggest that they might have a correlated
signalling value across life-history stages.
A Filtering Patch Antenna With Flexibly Controllable Radiation Nulls
Authors: Ma jingwei , Zhang Yi , zhou Dongfang , Lv Dalong
Published: September 2022

In this paper, a filtering patch antenna with flexibly controllable
radiation nulls is presented. The patch antenna is fed by an F-shaped
probe consisting of two arms along the Y-axis and a metal column along
the Z-axis. A broadside radiation null on the lower band is generated by
cross-coupling. Meanwhile, a folded defected ground structure (DGS) is
introduced to generate an upper band radiation null. By adjusting the
parameters of F-probe and DGS, two radiation nulls can be controlled
independently to achieve great out-of-band suppression. For
demonstration, a prototype is fabricated and measured. The simulation
results agree well with the measured ones. A flat in-band realized gain
of filtering antenna is about 7.1dBi. The proposed filtering antenna
operating at 2.33 GHz achieves a wide relative bandwidth of 9.8% and
out-of-band suppression level is more than 24dB.
COVID-19 encephalitis as a differential diagnosis of a Cyclosporine related Posterior Leukoencephalopathy Syndrome (PRES)
Authors: mrabet sanda , Jaziri Achraf , araoud maha , Sahtout Wissal , Zellama Dorsaf , Achour Abdellatif , Abdessayed Nihed , Mokni Moncef , Naija Salma , Amor Sana Ben , Souissi Alaa , Jemni Hela
Published: September 2022

PRES is a rare neurological disease possibly associated with the use of
calcineurin inhibitors like cyclosporine A. Severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus, is responsible
for the outbreak of coronavirus disease 19 (COVID-19) and can cause
neurological manifestations. We describe a case of CSA-related PRES
whose diagnosis was difficult due to concurrent infection with
SARS-CoV-2. The 16-year-old patient was known to have
corticosteroid-resistant nephrotic syndrome secondary to minimal change
disease. CSA was therefore introduced and on the fifth day of treatment,
he presented with seizures followed by fever. Biological and MRI data
were in favor of SARS-CoV-2 encephalitis. Relief of immunosuppression by
discontinuation of CSA was decided and the patient was put on
anticonvulsants. After being declared cured of COVID-19, which was
without other clinical signs, the CSA was reintroduced but the patient
presented with seizures the next day. This allowed us to rectify the
diagnosis and relate the seizures to a CSA-related PRES. We concluded
that infection with SARS-CoV-2 could be a differential diagnosis of a
PRES related to anticalcineurins.
Population Pharmacokinetics, Pharmacodynamics, and Pharmacogenetics Modeling of Oxypurinol in Hmong Adults with Gout and/or Hyperuricemia
Authors: Wen Ya-Feng , Brundage Richard , Roman Youssef , Culhane-Pera Kathleen , Straka Robert
Published: September 2022

Aim: Quantify identifiable sources of variability, including key
pharmacogenetic variants in oxypurinol pharmacokinetics and their
pharmacodynamic effect on serum urate. Methods: Hmong participants
(n=34) received 100 mg allopurinol twice daily for 7 days followed by
150 mg allopurinol twice daily for 7 days. Serum urates (SU) were
obtained pre- and post-allopurinol. Serum oxypurinol concentrations were
obtained at times 0, 2, 4, and 6 hours after the last dose. A sequential
population pharmacokinetic pharmacodynamics (PKPD) analysis with
non-linear mixed-effects modeling evaluated the impact of
anthropometrics, concomitant medications, and genetic variants on
oxypurinol PKPD parameters. Allopurinol maintenance dose to achieve
target SU was simulated based on the final PKPD model. Results: A
one-compartment model with first order absorption and elimination best
described the oxypurinol concentration-time data. Inhibitory of SU by
oxypurinol was described with a direct inhibitory Emax model using
steady-state oxypurinol concentrations. Fat-free body mass, estimated
creatinine clearance and SLC22A12 rs505802 genotype were found to
predict differences in oxypurinol clearance. Oxypurinol concentration
required to inhibit 50% of xanthine dehydrogenase activity was affected
by PDZK1 rs12129861 genotype. Most individuals with both
PDZK1 rs12129861 AA and SLC22A12 rs505802 CC genotypes
achieve target SU with allopurinol below the maximum dose, regardless of
renal function and body mass. In contrast, individuals with both
PDZK1 rs12129861 GG and SLC22A12 rs505802 TT genotypes
would require more than the maximum dose, thus alternative medications.
Conclusion: The proposed allopurinol dosing guide uses individuals’
fat-free mass, renal function, and SLC22A12 rs505802 and
PDZK1 rs12129861 genotypes to achieve target SU.
Relações empresariais e políticas públicas educacionais para o Ensino Médio
Authors: Lima Elsivan Machado Barbosa da Silva , Rodrigues Doriedson do Socorro
Published: September 2022

Este texto discute sobre políticas públicas e as relações entre o mercado e o público. Assim, apresentamos um breve contexto histórico em que evidencia o processo de disputa de construção do ensino brasileiro, considerando, como uma das políticas centrais, o Pacto Nacional pelo Fortalecimento do Ensino Médio, que articula e coordena ações e estratégias entre a União e os governos estaduais e distrital na formulação e implantação de políticas, com vistas a pretensamente elevar o padrão de qualidade dessa etapa de ensino em suas diferentes modalidades. A metodologia de abordagem qualitativa é cunhada por uma revisão bibliográfica e análise documental de documentos do Instituto Unibanco (IU), bem como Teses e Dissertações, com base em Severino (2018) e Bardin (1997). Evidenciamos, a partir deste estudo, que a relação público – privada foi se constituindo historicamente a partir da década de 1990 com a Conferência Mundial sobre Educação para Todos (Conferência de Jomtien), materializando-se ainda nessa mesma década com a Reforma do Aparelho do Estado, tratando-se de se fazer por meio da educação e suas políticas os interesses de mercado.
Testimony in stone: architecture of war from kluge to Herscher and Weizman
Authors: Ratkovic Marija
Published: September 2022

The article contributes to creating an outline of the significant postwar theoretical approaches that examine the role, purpose, and significance of architecture in war and war crimes. Starting from the Clausewitz thesis that ?war is not autonomous?, this paper attempts to reveal ?the blood that has dried in the codes? (Foucault), politics hidden behind the four walls of architecture. From the concepts of Brutality in Stone (Kluge), Warchitecture (Herscher) or Forensic Architecture (Weizman), through the lenses of architecture, the article exposes war, politics, and ideologies that shape and drive architecture by reimagining and repurposing it both in its primary, functional and cultural, representative sense. A shift from ?the era of the witness? (Felman) to the decade of evidence (Weizman) promotes architecture and its remains to the level of science, global governing, and law. The connection of timely-distanced emancipatory practices influenced by Holocaust studies establishes a discursive field for architecture as a performative rather than representative practice. The theoretical frame of the postwar landscape as second nature (Adorno) is crucial for discussing the role of architecture in the Holocaust. Furthermore, it stresses the work of Herscher and Weizman as a contribution to the critique of the depoliticized processes of resolution of the contemporary war crimes and post-conflict reconciliation. Architecture as a societal practice could potentially have a central position in memory and knowledge production, as well as the production of a counter-public sphere.
Scattered Reddish-brown Nodules on the Head in an Elderly Man: A Quiz
Authors: Zhang Xuetong , Ruan Jiali , Tang Zhuangli , Dai Ru , Lv Zhongfa
Published: September 2022

Abstract is missing (Quiz)