bluuebunny/crossref_metadata_2025 huggingface dataset:
Numerical Machine Learning
Authors: Wang Zhiyuan , Ameenuddin Irfan Sayed , Teoh Christopher , Hriday Bhoyar Priyanka
Published: August 2023

Numerical Machine Learning is a simple textbook on machine learning that bridges the gap between mathematics theory and practice. The book uses numerical examples with small datasets and simple Python codes to provide a complete walkthrough of the underlying mathematical steps of seven commonly used machine learning algorithms and techniques, including linear regression, regularization, logistic regression, decision trees, gradient boosting, Support Vector Machine, and K-means Clustering.

Through a step-by-step exploration of concrete numerical examples, the students (primarily undergraduate and graduate students studying machine learning) can develop a well-rounded understanding of these algorithms, gain an in-depth knowledge of how the mathematics relates to the implementation and performance of the algorithms, and be better equipped to apply them to practical problems.

Key features

- Provides a concise introduction to numerical concepts in machine learning in simple terms

- Explains the 7 basic mathematical techniques used in machine learning problems, with over 60 illustrations and tables

- Focuses on numerical examples while using small datasets for easy learning

- Includes simple Python codes

- Includes bibliographic references for advanced reading

The text is essential for college and university-level students who are required to understand the fundamentals of machine learning in their courses.
La epigrafía romana de Numancia (Soria, España). Una revisión crítica
Authors: Antolín Abad Alejandro
Published: August 2023

The discovery in 2021 of a new epigraph in the Numantia Site-Museum allowed us to tackle again the study of Numantine epigraphy. After an initial study in which a series of bibliographical errors and confusions accumulated over the years were perceived, we produced a new corpus in which all the documented fi nds are included, with updated information in accordance with current epigraphic studies. All of this is based on the premise of creating a very useful tool for the researcher, by presenting in a single work all the information available on the known pieces.
Radiografische evaluatie van de levergrootte bij honden na chirurgische behandeling van een extrahepatische portosystemische shunt
Authors: Bosdriesz C. , Devriendt N. , de Rooster H. , Dekkers M. , Paepe D. , Stock E.
Published: August 2023

Microhepathie is een frequent voorkomende bevinding bij honden met een congenitale extrahepatische portosystemische shunt (EHPSS). Chirurgische behandeling leidt bij het overgrote deel van de honden tot volledige sluiting van de EHPSS, terwijl bij een minderheid persisterende portosystemische shunting aanwezig blijft. In deze retrospectieve studie werd nagegaan of de levergrootte op abdominale radiografieën zes maanden postoperatief is toegenomen ten opzichte van de grootte van de lever preoperatief, en of de toename groter is bij honden met een gesloten EHPSS dan bij honden met persisterende portosystemische shunting. Er was bij twee derde van alle honden een toename in levergrootte aanwezig zes maanden postoperatief, alhoewel deze toename niet statistisch significant was (p = 0,148). Er was ook geen significant verschil in toename van de levergrootte postoperatief tussen honden met een gesloten EHPSS en met persisterende shunting (p = 0,649). In deze studie werd er op basis van abdominale radiografieën geen duidelijke toename van de levergrootte waargenomen, en er kon geen informatie over het al dan niet volledig sluiten van de EHPSS verkregen worden.
Highly Religious Young Poles in the Process of Transformation
Authors: Boguszewski Rafał , Mariański Janusz
Published: August 2023

The article describes highly religious young Poles who are at the stage of entering adulthood (aged 18-19 and attending the final grades of high school). In the empirical analysis, we use the existing data from quantitative research carried out in 1996, 2010, and 2021. The same methodology for the implementation of the survey, including sample selection, as well as a broadly comparable research tool, allowing to capture significant changes, tendencies, and trends that have occurred among young Poles in the last 25 years in terms of religiousness.
The data show that despite a significant decrease in the percentage of people who define themselves as religious, and even more so as regularly practicing religion, the percentage of deeply religious people and regular religious practitioners remains relatively constant (about 5% of the population of young Poles who have reached the age of majority). The question arises whether the socio-demographic structure of this group remains stable over the time and whether and to what extent it differs from the structure of other groups, including less religious and non-religious people. The article attempts to answer this question.
Light and heavy excitons in strained CdTe/CdZnTe quantum wells
Authors: Kotova L. V.  , Belova D. D.  , Andre  R.  , Mariette H.  , Kochereshko V. P.
Published: August 2023

The spectra of photoluminescence and polarized reflection under normal and oblique incidence of light from structures with quantum wells with symmetric Cd0.9Zn0.1Te/CdTe/Cd0.9Zn0.1Te and asymmetric Cd0.9Zn0.1Te/CdTe/Cd0.4Mg0.6Te barriers have been studied. Due to the mechanical stresses caused by the mismatch of the crystal lattices of the wells and barriers, the energy of light holes in quantum wells was higher than in barriers, i.e., the band structure for them was of type II. However, in the reflection spectra, the lines of heavy and light excitons had comparable intensities. In structures with symmetric barriers, exciton resonances, which do not appear in the photoluminescence spectra, were found in the reflection spectra. A detailed calculation of the energy levels and reflection spectra has been carried out Keywords: quantum well, reflection, excitons, strain.
Research on Possible Causes and Solutions about the Problem of Second Language Vocabulary Acquisition Decay
Authors: Luo Gongke
Published: August 2023

English vocabulary learning is a difficult task for second language students. Therefore, it is very essential for second language students to master the methods of vocabulary memorization and how to prolong the time of vocabulary memorization. This paper will divide into three sections, namely describing a context with the problem of the accelerated lexical decay in a specific context in a Chinese after-school language class with details; analyzing possible causes and general solutions mentioned in vocabulary learning literature; as well summarizing what solutions to work in the specific after-school class in China.
The role of moral disengagement and authoritarian parenting style towards cyberbullying attitude among social media users
Authors: Rahmawati Nabilla Putri , Virlia Stefani
Published: August 2023

The increase in internet users and the lack of ethics in using the internet have become one of the phenomena that trigger cyberbullying on social media among adolescents. Various internal and external factors can influence cyberbullying attitudes, including moral disengagement and authoritarian parenting style. This study examines the role of moral disengagement and authoritarian parenting style towards cyberbullying attitudes in social media users. The participants in this study were 271 junior high school students aged 12-15 years, accessing social media for more than 2 hours a day and living with both parents. The data collection method used a survey by distributing questionnaires to junior high schools in Surabaya. The scales used were Cyberbullying Attitudes, Moral Disengagement Scale, and Authoritarian Parenting Style (PAQ). The data analysis technique used multiple regression analysis. Reporting multiple regression results in the role of moral disengagement and authoritarian parenting style towards cyberbullying attitudes, R²=0.434, F(102.626), p<0.001 from the mother side and R²=0.432, F(102.003), p<0.001 from father side. However, in this study, 43% contribution comes from moral disengagement, and the authoritarian parenting style has no effect, considering that research participants are individuals in the stage of social identity confusion, so the role of peers could be more influential.
Adaptation and psychometric properties of the Indonesian version of fear of happiness scale
Authors: Najib Asalia , Kumalasari Asteria Devy
Published: August 2023

A survey of cultural ideas shows that some people have a belief that happiness, especially unnatural levels, should be avoided. This belief is called the Fear of Happiness which is the thought that happiness may have negative consequences. In this study, the researcher intends to adapt the Fear of Happiness Scale measuring instrument developed by Joshanloo (2013). The adaptation process follows the guidelines of the ITC “Guidelines for Translating and Adapting Tests”. Based on trials on 1652 citizens of Indonesia of various ages and cultures, the results of data processing show that this measuring instrument meets the reliability test and test-retest which is processed with Intraclass Correlation Coefficient, as well as evidence of validity, both content validity, factorial and construct validity. Thus, the adaptation is able to measure the image of the fear of happiness in Indonesian society.
Análise de argumentos em decisões penais do stf
Authors: De Barros Ibarra Papa Douglas
Published: August 2023

Objetivo: o presente artigo apresenta fundamentos normativos e metodológicos para pesquisas empíricas em torno das decisões penais do Supremo Tribunal Federal – STF, notadamente a partir da ideia de representação argumentativa, no intuito de não apenas realçar a argumentação constitucional como ferramenta de legitimação das decisões do tribunal, mas de realçar especialmente caminhos metodológicos para a sua análise, objetivando a busca de padrão racional de decisão no campo penal, sem desconsiderar o modelo de deliberação tradicionalmente desenvolvido na Suprema Corte brasileira. Método: assim, o trabalho parte da hipótese de que a única forma de conferir legitimidade democrática às decisões do STF é associando o exercício da autoridade do tribunal a uma noção de representação, para, através de raciocínio indutivo – por meio do qual se parte de dados particulares, suficientemente constatados, mirando uma verdade geral ou universal – e mediante prática deliberativa da Corte, investir em propostas metodológicas para se alcançar forma ideal de argumentar, especialmente nos casos penais, a fim de que a deliberação neste campo se torne mais transparente e cumpra a sua função social em um contexto democrático. Resultado: busca-se, assim, amplo espaço de aperfeiçoamento institucional do STF em matéria decisória, considerando as especificidades inerentes aos julgamentos criminais.
conceito de consumidor hipervulnerável
Authors: Winkel Santin Douglas Roberto
Published: August 2023

Objetivo: o presente estudo tem por finalidade investigar quais grupos sociais e indivíduos vêm sendo entendidos como abarcados pela condição de hipervulneráveis no âmbito das relações de consumo com base na análise das decisões do Superior Tribunal de Justiça – STJ. Para tanto, partiu-se da compreensão da vulnerabilidade do consumidor como elemento caracterizador da relação jurídica de consumo e da exploração dos diferentes aspectos do conceito de hipervulnerabilidade. Por fim, realizou-se levantamento e análise de situações que têm sido entendidas como abrangidas pela noção de hipervulnerabilidade nas decisões identificadas do STJ. Método: trata-se de pesquisa desenvolvida numa abordagem indutiva, buscando-se estabelecer situações, pessoas e grupos concretamente reconhecidos como hipervulneráveis nas decisões do STJ em matéria consumerista. A investigação é apoiada em pesquisa documental, consubstanciada no levantamento e na análise das decisões do STJ sobre a matéria. O estudo é apoiado ainda por levantamento bibliográfico, notadamente das principais referências doutrinárias selecionadas acerca da matéria. Resultado: concluiu-se que a atual orientação jurisprudencial do STJ aponta uma concepção de hipervulnerabilidade que abarca tanto indivíduos e grupos sociais (idosos, deficientes, crianças), cuja especial vulnerabilidade decorre de aplicação direta de disposições constitucionais, assim como indivíduos que, embora não tendo sua vulnerabilidade expressamente reconhecida no texto constitucional, ocupam posição concreta de especial vulnerabilidade, tais quais os portadores de doença celíaca.
Un análisis bibliométrico sobre el uso de la gamificación para la prevención de la deserción en Ambientes Virtuales de Aprendizaje
Authors: Aldana Aldana Laura Lizeth
Published: August 2023

La innovación en el área educativa.
Voces de los de los futuros docentes sobre la formación en investigación
Authors: Mogollón Villamizar Mildred Emeira , Ávila Zárate Adriana Inés , Quin Coronel Sara Valentina , Rojas Rangel Deysy Tatiana
Published: August 2023

Este artículo corto emerge del trabajo que las participantes del semillero Proyección Docente Investigador en la Universidad Autónoma de Bucaramanga - UNAB, estudiantes de la Licenciatura en Educación Infantil, han venido desarrollando respecto a analizar cómo se está llevando a cabo la formación para la investigación. A partir de la realización de grupos focales con estudiantes de diferentes semestres se lograron identificar tanto aspectos positivos como oportunidades de mejora para enriquecer este proceso formativo en aras de responder a los intereses y necesidades de quienes se están preparando para ser maestros. Este ejercicio se enmarca en un proyecto que busca valorar las habilidades investigativas de los futuros licenciados, en atención a que existe una fuerte relación entre la docencia y la investigación en el que se asume la práctica pedagógica como un escenario ideal para investigar. Por tanto, lo que se describe en este artículo corto corresponde a resultados preliminares de dicho proyecto.
Understanding corporate social responsibility, employee psychological capital and work performance: The perspective of tourism in the emerging economy
Authors: Sami Lamaan , Azhar Mohd , Yazdani Wasi , Akhtar Mohd Junaid , Aslam Aamir
Published: August 2023

Corporate social responsibility (CSR) improves business performance in a significant way (Manzoni & Islam, 2015). This study examines how travel and tourism firms handled their CSR during the COVID-19 pandemic and how it affected employee satisfaction (EST) with corporate responses on employee psychological capital (PsyCap) that was measured through self-efficacy (SEC), hope (HOP), resilience (RES) and optimism (OPT). This study also examines PsyCap’s impact on employee work performance (WPM). An online questionnaire was used to obtain data from Indian travel industry personnel to support the study’s conceptual model. A total of 301 valid and usable responses were obtained for the final analysis, which was analyzed using Statistical Package for the Social Sciences (SPSS) 20 and Analysis of Moment Structures (AMOS) 22 software. The model underwent validation through confirmatory factor analysis (CFA) and structural equations modeling (SEM). CSR strongly affects EST, which positively impacts all four variables of employee PsyCap. A positive association of SEC, HOP, and OPT with WPM has also been found, while the association between RES and WPM is insignificant. These variables explained about 53% (R2 = 53.2) of the variance in work performance. This study offers academia and industry practitioners valuable insights into CSR during natural disasters and health hazards.
Classic Human Astrovirus 4, 8, MLB-3 and likely new genotype 5 sub-lineage in stool samples of children with Acute Flaccid Paralysis (AFP) in Nigeria
Authors: Olubusuyi Adewumi Moses , IFEORAH IJEOMA , Temitope Faleye O. C. , Coninck Lander De , Sheriff Agbaje Tunde , Uwem George Etop , Bernard Onoja Ayenbe , Oluseyi Olayinka Adebowale , Elijah Oni Igbekele , Toluwani Ajileye Goodnews , Arthur Oragwa Obinna , Toluwanimi Akinleye Emmanuel , Bolutife Popoola Olubukola , Damilola Osasona Gideon , Titilola Olayinka Olaitan , Oluwadamilola George Adefunke , Muhammad Ahmed Iluoreh , Omotosho Komolafe Isaac , Adeniji J. A. , Matthijnssens Jelle
Published: August 2023

Introduction: Acute viral gastroenteritis is a common illness
especially in developing countries. Globally, the role of human
astroviruses (HAstV) in gastroenteritis among children and elderly is
well documented. But there exists a substantial dearth of information on
HAstV strains circulating in Nigeria. Method: Viral like
particles (VLPs) were purified from stool samples from children
diagnosed with acute flaccid paralysis (AFP) between January and
December 2020 from five states in Nigeria, using the NetoVIR protocol.
Extracted viral RNA and DNA were subjected to a reverse transcription
step, and subsequent random PCR amplification. Library preparation and
Illumina sequencing were performed. Using the Virome Paired-End Reads
(ViPER) pipeline, raw reads were processed into genomic contigs.
Phylogenetic and pairwise identity analysis of the recovered HAstV
genomes was performed. Results: Six near complete genome
sequences of HAstV were identified and classified as HAstV 4 (n=1),
HAstV5 (n=1), HAstV8 (n=1) and MLB-3 (n=3). The HAstV5 belonged to a yet
unclassified sub-lineage which we tentatively named HAstV-5d.
Phylogenetic analysis of ORFs 1a, 1b and 2 suggested recombination
events inside the MAstV1 species. Furthermore, phylogenetic analysis
implied a geographic linkage between the HAstV5 strain from this study
with two strains from Cameroon across all the genomic regions.
Conclusion: We report for the first time the circulation of
HAstV genotypes 4, 8 and MLB-3 in Nigeria and present data suggestive
for the existence of a new sub-lineage of HAstV5. To further understand
the burden, diversity, and evolution of HAstV increased research
interest as well as robust HAstV surveillance in Nigeria is essential.
Predation affects body shape in the knife livebearer Alfaro cultratus (Cyprinodontiformes: Poeciliidae)
Authors: Ardon Diego , Golden Kaitlyn , Williams Trevor , Belk Mark , Johnson Jerald
Published: August 2023

Livebearing fishes are a standard model for studying the effect of
predation on prey biology. Numerous studies have found differences in
life history, sexual selection, behavior, and morphology between
populations of the same species that co-occur with predators and those
that do not. Alfaro cultratus is a livebearing fish with populations in
different predation environments, but unlike other livebearers, this
species also has an extreme body shape that is laterally compressed.
Given this unusual morphology, we asked if predation environment would
still predict overall body shape, as has been documented in other
species. We collected specimens from both predator and no-predator sites
in Costa Rica. We used a geometric morphometrics analysis to determine
if body shape is affected by the predation environment while controlling
for size and river gradient. Body shape does indeed differ between
predation environments; however, the observed differences contrast with
the patterns found in other livebearer systems. Alfaro cultratus
in predation environments had deeper and shorter bodies and deeper
caudal peduncles than those found in environments without dominant fish
predators.
On a quantum inspired approach to train machine learning models
Authors: Sellier Jean Michel
Published: August 2023

In this work, a novel technique to train machine learning models is
introduced, which is based on digital simulations of certain types of
quantum systems. This represents a drastic departure from the standard
approach which, to these days, is based on the use of actual physical
quantum systems. Thus, to provide a clear context, a proper introduction
to the field of quantum machine learning is first provided. Then, we
proceed with a detailed description of our proposed method. To conclude,
some preliminary, yet compelling, results are presented and discussed.
Although at a seminal stage, the author firmly believes that this
approach could represent a valid and robust alternative to the way
machine learning models are trained today.
Cloning and recombinant expression of Caspase-activated DNase orthologous gene of Giardia lamblia
Authors: López-Moreno Héctor Samuel , Villa-Medina María Cristina , Díaz-Gaxiola Cecilia , Rosales-Reyes Roberto , Durán-Pérez Sergio Alonso , Vega-Castillo Ulises , Rodríguez-Rochín Jesús Alberto , León-Sicairos Claudia del Rosario , Beltrán-López Evangelina
Published: August 2023

In eukaryotic cells, mitochondria play a key role in apoptosis, but
Giardia lamblia only possesses a mitochondrial remnant, the
mitosome. However, this protozoan can die by an apoptosis-like process,
probably by an apoptosis-mitochondrial-independent pathway. Here, we
aimed to identify, clone, express, and characterize the
caspase-activated DNase (CAD) of G. lamblia. Using a commercial
polyclonal antibody that recognizes mouse, rat, and human CAD (hCAD), we
developed an immunoproteomic analysis using a crude extract of
curcumin-treated G. lamblia trophozoites (CEGl), detected a spot
of 42kDa, and pI 9.4, similar to hCAD. This spot was sequenced by LC-MS.
The proteomic profile (eleven peptides) matched with a novel protein of
383 residues, with a predicted 42KDa, pI 9.4, with a CIDE-N domain and
putative H-K-H cata-lytic motif. Afterward, we cloned the full-length
gene (GenBank: ON707040), expressed it, and purified it as a H
tag-recombinant protein in Escherichia coli,
which also was recognized by commercial anti-CAD. In conclusion, gCAD is
an orthologous protein of hCAD and will allow us to determine its role
in the apoptosis-like signaling pathway in G. lamblia.
Vascular reactions in hereditary angioneurotic edema.
Authors: Juhlin L , Michaëlsson G.
Published: August 2023

No abstract available
Chronic urticaria. A clinical study with special reference to vascular reactions
Authors: Michaëlsson G.
Published: August 2023

No abstract available
Herpes simplex in the course of zoster.
Authors: Kandil E.
Published: August 2023

No abstract available
Dermo-epidermal junction in invasive squamous cell carcinoma. An electron
Authors: Kobayasi T.
Published: August 2023

No abstract available
The water-binding properties of the water-soluble substances in the horny layer.
Authors: Smeenk G , Rijnbeek AM.
Published: August 2023

No abstract available
Sensitizing properties of p-amino-diphenylamine.
Authors: Shonning L.
Published: August 2023

No abstract available
Urticaria pigmentosa associated with anetoderma
Authors: Carr RD.
Published: August 2023

No abstract available
Allergic diseases among relatives of patients with allergic contact dermatitis
Authors: Forsbeck M. , Skog E. , Ytterborn KH.
Published: August 2023

No abstract available
Diminished phagocytic function in patients with alopecia
Authors: Rawnsley HM. , Shelley WB.
Published: August 2023

No abstract available
An electron microscopical study of Bloch-Sulzberger syndrome (incontinentia pigmenti)
Authors: CK Wong , CJ Guerrier , DC Macmillan , HR. Vickers
Published: August 2023

No abstract available
Distribution of S35-L-cystine in mice after intraperitoneal injection as revealed by whole-body autoradiography
Authors: Forslind B.
Published: August 2023

No abstract available
The fractionation of sweat from atopic and normal subjects
Authors: DW Cotton , AH Sutorius , EJ. Urselmann
Published: August 2023

No abstract available
Liver biopsy in methotrexate treatment
Authors: H Zachariae , T. Schiodt
Published: August 2023

No abstract available
Erythrokeratodermia figurata variabilis
Authors: S. Ohman
Published: August 2023

No abstract available
Eccrine spiradenoma
Authors: G. Michaëlsson
Published: August 2023

No abstract available
Elastase and trypsin inhibitors of human skin and serum. Partial purification and characterization
Authors: SK Junnila , CT Jansén , VK. Hopsu-Havu
Published: August 2023

No abstract available
Plethysmographic recordings of skin pulses. IV. The vasoconstrictive effect of steroids in normal and stripped skin
Authors: P. Thune
Published: August 2023

No abstract available
A study on lymphocyte transformation in light dermatoses. Preliminary report
Authors: I Horkay , C. Mészáros
Published: August 2023

No abstract available
Familial localized heat urticaria of delayed type
Authors: G Michaëlsson , AM. Ros
Published: August 2023

No abstract available
Isolation-ward treatment for dermatoses. I. Clinical experiences
Authors: L Molin , G Rajka , C. Tarras-Wahlberg
Published: August 2023

No abstract available
Energy metabolism of human epidermis during prolonged suction leading to blister formation
Authors: MH Härkönen , VK. Hopsu-Havu
Published: August 2023

No abstract available
Verrucae vulgares. II. Demonstration of a complement fixation reaction
Authors: J. Genner
Published: August 2023

No abstract available
Proliferative cells in the human sebaceous gland. Labelling index and regional variations
Authors: G Plewig , E Christophers , O. Braun-Falco
Published: August 2023

No abstract available
Studies on dithranol and dithranol-like compounds. II. Mutagenicity
Authors: Zetterberg G. , Swanbeck G.
Published: August 2023

No abstract available
Selenium sulphide treatment of tinea versicolor
Authors: K. Hersle
Published: August 2023

No abstract available
Basal cell carcinoma in Gardner's syndrome
Authors: Lewis RJ , Mitchell JC
Published: August 2023

No abstract available
Beta-hydroxyacyl-CoA dehydrogenase and glucose-6-phosphte dehydrogenase in normal human skin and in some papulosquamous diseases of the skin
Authors: Hammar H.
Published: August 2023

No abstract available
Direct recovery of histamine from cutaneous anaphylaxis in man
Authors: Sondergaard J. , Greaves MW.
Published: August 2023

No abstract available
Aspects of the natural history of herpes zoster. A follow-up investigation of
Authors: Molin L
Published: August 2023

No abstract available
Phenylethanolamine N-methyltransferase-like immunoreactivity in psoriasis. An immunohistochemical study on catecholamine synthesizing enzymes and neuropeptides of the skin
Authors: Johansson O , Olsson A  , Enhamre A , Hammar H  , Goldstein M
Published: August 2023

Immunoreactivity for phenylethanolamine N-methyltransferase (PNMT), the enzyme involved in the conversion of norepinephrine to epinephrine, was present in the basal epidermis and upper dermis in 16 patients with psoriasis. The amount of immunoreactivity was increased tenfold in involved compared to uninvolved skin as characterized by computer-assisted image analysis. In skin from healthy volunteers no immunoreactivity could be found. In our subjects, no immunoreactivity was observed for the other catecholamine synthesizing enzymes (tyrosine hydroxylase; dopa-decarboxylase; dopamine-beta-hydroxylase), apart from single tyrosine hydroxylase positive adrenergic vascular nerves. Furthermore, in psoriasis, the immunoreactivity pattern of the peptides somatostatin, substance P, vasoactive intestinal polypeptide and bombesin was in agreement with skin from healthy volunteers.
Transformation of lymphocytoma cutis into a malignant lymphoma in association with the sign of Leser-Trélat
Authors: Halevy S , Sandbank M.
Published: August 2023

A patient is described in whom transformation of lymphocytoma cutis (LC) into malignant lymphoma, diffuse, mixed small and large lymphocytes, occurred in association with the sign of Leser-Tr√©lat (LT), which is a marker for internal malignancy. To the best of our knowledge, such an association has not been reported previously.
Evidence for spirochetal origin of circumscribed scleroderma (morphea)
Authors: Aberer E , Stanek G  , Ertl M , Neumann R
Published: August 2023

Acrodermatitis chronica atrophicans (ACA) and morphea are clinically distinct skin diseases with some common features and possible coexistence. We found antibodies to Borrelia burgdorferi in eight of fifteen patients with morphea. Six of them had IgG antibodies and two both IgG and IgM antibodies. Four of the eight seropositive and five of the seven seronegative patients had been treated with high dose penicillin previously. Spirochetal organisms could be cultured in Barbour-Stoenner-Kelly´s medium from a skin biopsy of one seropositive untreated patient. Spirochetes were recovered from histological sections in three of eight, two seropositive and one seronegative morphea and in one of three erythema chronicum migrans patients by an avidin-biotin immunoperoxidase method. The similar clinical picture of ACA and morphea, the response to penicillin therapy in both entities, the presence of antispirochetal antibodies, the isolation of spirochetes in culture and the detection of spirochetal organisms on histological sections suggest a close relationship among these diseases. We conclude that morphea may represent a Borrelia infection. The correlation to ACA is discussed.
A method for testing the effect of pressure-relieving materials in the prevention of pressure ulcers
Authors: Karlsmark T , Kristensen JK.
Published: August 2023

A method is described by which the effect of pressure and relief of pressure on blood flow in cutaneous and subcutaneous tissue can be evaluated. Five normal persons were placed supine on a transparent polyacrylate board and blood flow in the skin overlying the sacral area was measured. Cutaneous blood flow was measured by the laser-Doppler technique and subcutaneous blood flow was measured by the 133Xenon washout technique using atraumatic application. Blood flow was measured by both techniques before and after relief of pressure, using the antipressure material Comfeel Pressure Relieving Dressing (in the following referred to as Comfeel PRD) consisting of a foamy plastic material with an adjustable central opening. With this material, it was possible to obtain relief of pressure which was shown as a significant increase in blood flow measured by both methods. It is suggested that the methods described should be used to test other materials as well.
Pseudouridine excretion in patients with psoriasis
Authors: Clemmensen OJ , Kieffer M  , Sjølin KE
Published: August 2023

The excretion of pseudouridine in the urine of 17 patients with psoriasis was significantly increased. The largest increase was found in patients with psoriatic arthritis. No correlation between the extent of psoriasis and pseudouridine excretion was found. The excretion of pseudouridine was followed in 10 of the 17 patients during treatment with anthralin or PUVA. Pseudouridine excretion decreased significantly during therapy. The possible application of pseudouridine excretion in monitoring the disease activity in psoriasis is discussed.
Contact allergy to the active ingredients of Kathon CG in the guinea pig
Authors: Bruze M , Fregert S  , Gruvberger B , Persson K
Published: August 2023

Preservative Kathon CG (K-CG) is a commercial preparation, consisting of the two active ingredients (a.i.), 2-methyl-4-isothiazolin-3-one (243-K-CG) and 5-chloro-2-methyl-4-isothiazolin-3-one (5243-K-CG) and also of other components. Both a.i. are known contact sensitizers in humans. In this study guinea pig maximization tests were performed with the a.i. in order to assess and compare the degrees of the sensitizing capacities. The animals were also rechallenged with the sensitizer and 4 chemically related compounds, all being preservatives or known ingredients in preservatives, in order to study the cross-reaction patterns. 5243-K-CG was demonstrated to be a strong sensitizer and 243-K-CG a weak sensitizer. With 5243-K-CG as the sensitizer, 4.5-dichloro-2-methyl-4-isothiazolin-3-one was a possible cross-reacting compound. Possible cross-reactivity was indicated between the a.i. when 243-K-CG was the sensitizer.
Dermatologic disorders in patients with thymoma
Authors: Gibson LE , Muller SA.
Published: August 2023

We describe the cutaneous disorders in 172 patients with thymoma. Myasthenia gravis was the most common additional disease. Cutaneous disorders were found in 34 patients; 19 had skin disorders at the time of diagnosis of thymoma and 15 developed skin disorders after diagnosis of thymoma. Cutaneous fungal diseases were found in fewer than 10% of the patients (tinea pedis excluded). One patient with chronic mucocutaneous candidiasis was included in this group. Two patients with lichen planus, 2 with pemphigus, 2 with myositis, and 1 with lupus-like disease were also included in this study. Patients with skin disorders were no different than patients without these disorders with regard to thymoma histology, age at diagnosis, sex, or presence of myasthenia gravis. There were no associations between these variables and the patients who developed these skin disorders after diagnosis of thymoma. Thymectomy did not alter the clinical course with respect to cutaneous diseases.
Membrane-coating granules in "dry" non-eczematous skin of patients with atopic dermatitis. A quantitative electron microscopic study
Authors: Werner Y , Lindberg M  , Forslind B
Published: August 2023

In recent years much interest has been focused on the functions of the membrane-coating granules (MCGs). These granules seem to play an essential role in the formation of the barrier of the stratum corneum by extruding their lipid-rich content into the extracellular space of the corneocytes. The dry non-eczematous skin in atopic dermatitis has been reported to have defective barrier function. In the present study a quantitative electron microscopic analysis was made of the volume of MCGs in the transition zone between the stratum granulosum and stratum corneum in dry skin of patients with atopic dermatitis. The relative volume of MCGs was significantly greater than that in normal skin. This finding may indicate a disturbance of the "maturation" of the MCGs, leading to a defect in the barrier function in atopic dermatitis.
The detection of basal cell determinants in human basal cell carcinomas using two different monoclonal antibodies
Authors: Habets JM , Tank B  , Vuzevski VD , Van Reede EC  , Stolz E , Van Joost T
Published: August 2023

This report deals with the reaction pattern(s) of two monoclonal antibodies (MoAbs) with normal skin and basal cell carcinomas (BCC). Using indirect immunoperoxidase (IIP) and indirect immunofluorescence (IIF) techniques, MoAb 12 G7 was observed to react with a determinant related to the cell membrane of the epidermal basal cells. In the IIP technique MoAb 12 G7 showed a positive reaction with 32 out of 34 BCC (94%), while in IIF all the 14 BCC that were studied were positive. In most cases only the cells at the periphery of the tumour nests were stained. MoAb 253 B7 reacted with cytoplasmic determinant(s) of the epidermal basal cells both in the IIF as well as in the IIP techniques. Using the IIP technique only 5 out of 34 BCC (15%) showed a positive reaction with this MoAb. Four of the 5 positively staining tumours showed aggressive histological features. Using IIF technique only 2 out of 14 BCC were positive. The results presented in this communication are discussed with regard to the possible expression of selective differentiation and tumor-associated determinant(s) in BCC.
Monoclonal antibody AHS-7 defines a specific basement membrane antigen localized to the hemidesmosome zone
Authors: Aiba S , Masuko T  , Yagita H , Hashimoto Y  , Tagami H
Published: August 2023

MoAb AHS-7 labels the basement membrane of the skin. In this report, we have determined the precise localization and molecular nature of the antigen(s). After epidermal-dermal separation by suction blistering, the antigen(s) were detected on the epidermal side. Immunoelectron microscopy revealed the reaction product observed as a discontinuous line along the plasma membrane of the basal keratinocytes, which corresponded to the distribution of the hemidesmosomes. We extracted the proteins from the normal human epidermis separated from the dermis by suction blistering. After being separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, the proteins were electrophoretically transferred to nitrocellulose sheets, and the antigen(s) were identified by immunoperoxidase staining with MoAb AHS-7. We detected 4 protein bands of molecular weights of 82 kd, 104 kd, 120-135 kd, and 140-160 kd when unreduced, in contrast to only two bands of 41 kd and 52 kd when reduced. These data suggest that the antigen(s) recognized by MoAb AHS-7 defines a unique antigen, different from bullous pemphigoid antigen on the hemidesmosome zone.
Keratinocyte T6 antigen expression after PUVA therapy
Authors: Dreno B , Milpied B  , Stalder JF , Guillet G  , Litoux P
Published: August 2023

We report T6 antigen expression on keratinocytes in 11 cutaneous T lymphomas treated by PUVA therapy. This staining was absent before treatment. T6 reactivity was strictly limited to cell membrane. The nature of this expression is discussed, and it is suggested that it could be attributed to a passive diffusion from Langerhans´s cells.
Leukocyte migration in vivo and in vitro in patients with psoriasis
Authors: Scheja A , Bruze M  , Forsgren A
Published: August 2023

Leukocyte migration in vivo was studied with a skin chamber technique in 21 patients with active psoriasis vulgaris and 18 with cleared psoriasis vulgaris. Measuring over 24 h, no difference was found between healthy volunteers and most patients with active psoriasis, although a subgroup of patients with long-lasting relapses showed subnormal migration values. In patients with cleared psoriasis on the other hand the in vivo leukocyte migration values were increased. In addition, leukocyte migration in vitro under agarose was studied, but no difference was found between healthy controls and patients with psoriasis, active or cleared.
Analysis of increased urinary acid glycosaminoglycans in a patient with relapsing polychondritis
Authors: Tadaki T , Aiba S  , Igarashi M , Tagami H
Published: August 2023

We analysed the composition of glycosaminoglycans (GAGs) found in an increased amount in the urine from a patient with relapsing polychondritis (RP) by means of electrophoresis, since to our knowledge no analytical studies on the composition of GAGs in the urine from the patients with RP have been performed. Unexpectedly, the major GAGs detected in increased amount in the urine were found to be dermatan sulfate (DS) and hyaluronic acid (HA), the excretion of which correlated with the activity of the disease. Both DS and HA are the major components not of the cartilage but of the skin. Therefore, our findings suggest that the increased GAGs in RP are derived from skin or other tissues containing these GAGs rather than from the cartilage, unless there is an extensive cartilage destruction.
Atopic dermatitis, house dust mite allergy and month of birth
Authors: Beck HI , Hagdrup HK.
Published: August 2023

An analysis of the month of birth in 210 patients with atopic dermatitis and a positive prick test towards the house dust mite (Dermatophagoides pteronyssinus) showed a significantly higher prevalence of birth in the interval May to November when compared with the expected distribution (p less than 0.01). A subdivision of the AD patients due to the concomitant presence of asthma showed no differences as the relative risk was nearly the same in the two subgroups. This observation indicates that a consistent seasonal preference of birth in patients with atopic dermatitis only applies to the skin disease and not to coexistent asthma.
Chronic eczematous dermatitis of the hands: a comparison of PUVA and UVB treatment
Authors: Rosén K , Mobacken H  , Swanbeck G
Published: August 2023

The efficacy of PUVA and UVB treatment in chronic eczematous dermatitis of the hands was compared in a randomised controlled study including 35 patients who were randomly allocated to PUVA or UVB treatment. One hand was exposed to light and the other served as an untreated control. The dermatitis cleared on the treated hand in all PUVA patients, but in 9 out of 14 there was a relapse within three months. In the UVB group clearing of the skin lesions was not achieved, but compared with the "untreated" hands a statistically significant improvement was found at 12 weeks of treatment. A statistically significant improvement of "untreated" hands was found in both groups. PUVA and UVB treatments are alternative treatment modalities in patients with recalcitrant chronic eczematous dermatitis of the hands. PUVA is superior to UVB.
High prevalence of cervical dysplasia in female consorts of men with genital warts
Authors: Höckenström T , Jonassen F  , Knutsson F , Löwhagen GB  , Rådberg T
Published: August 2023

Altogether 51 regular female consorts of men attending a venereal disease clinic for genital warts were examined using colposcopy, vaginal cytology and--when needed--surgical biopsy. Abnormal cytological smears were found in 18 out of 49 consorts (37%), which should be compared with 8 out of 124 (6%) matched female controls from a family planning clinic (p less than 0.001). Possibly premalignant lesions, i.e. atypical condylomata and/or frank dysplasia, were found in 14 (27%) out of 51 consorts. The prevalence of abnormal smears or biopsy-proven dysplasia was approximately the same in consorts with and without external warts. These findings call for close attention to the risk of development of cervical dysplasia in female consorts of men with genital warts.
The Ectodermal Dysplasias-Burden of Disease Score: Development and Validation of an Ectodermal Dysplasia Family/Parental Burden Score
Authors: Dufresne Helene , Maincent Oriane , Taieb Charles , Bodemer Christine , Hadj-Rabia Smail
Published: August 2023

Ectodermal dysplasias are genetic conditions affecting the development and/or homeostasis of 2 or more ectodermal derivatives, including hair, teeth, nails, and certain glands. No tool is available to assess the burden of ectodermal dysplasias and its multidimensional impact on patients and their families. This study developed and validated a familial/parental 19-item burden questionnaire designed specifically for ectodermal dysplasias. Each group of questions was linked to 1 of the following dimensions: (i) Impact of the disease on social life and hobbies; (ii) Future prospects; (iii) Restraint of the disease on outdoor activities; (iv) Financial burden of the disease; (v) Acceptance of the disease. Cronbach’s alpha was 0.91 for the entire Ectodermal Dysplasias-Burden of Disease (ED-BD) scale, confirming excellent internal coherence. Intradimensional coherences all demonstrated excellent reliability (α > 0.76). The ED-BD questionnaire was highly correlated with the Short Form-12 and Psychological General Well Being Index validated questionnaires. Cultural and linguistic validation in US English was conducted. Development and validation of the questionnaire was based on data from patients with the 2 main ectodermal dysplasias subtypes. This ED-BD questionnaire represents the first specific assessment tool for evaluating the familial/parental burden of ectodermal dysplasias.
External beam radiotherapy of prostate cancer with or without high dose-rate brachytherapy: the Norwegian experience with long-term urinary and bowel adverse effects
Authors: Wedde Trude B. , Smaastuen Milada C. , Vatne Kari , Schulz-Jaavall Melanie Birthe , Fosså Sophie D. , Lilleby Wolfgang LH.
Published: August 2023

Background: There are few studies utilizing the Expanded Prostate Index Composite questionnaire-26 (EPIC-26) questionnaire to examine the long-term association between Domain Summary Scores (DSSs) and Quality of Life (QoL) after External Beam Radiation Therapy (EBRT, 3DCRT [3D conventional radiotherapy]/IMRT [intensity modulated radiation therapy]) versus EBRT combined with High-Dose-Rate Brachytherapy (BT+, 3DCRT [3D conventional radiotherapy]/IMRT). In this cross-sectional study we compare long-term adverse effects and QoL after BT+ with EBRT.Methods: Prostate Cancer Survivors who at least 5 years previously, had undergone BT+ at Oslo University Hospital between 2004 and 2010 (n = 259) or EBRT (multicentre cohort) between 2009 and 2010 (n = 99) completed a questionnaire containing EPIC-26, Short Form-12 and questions regarding comorbidity/social status. Results were presented as DSSs and Physical/Mental Composite Scores of QoL (PCS/MCS). Regression analyses explored firstly the associations between treatment modality and DSSs and secondly the impact of DSSs on QoL. We estimated the proportions of patients with big/moderate problems. Clinical relevance was set according to the lowest limit of published Minimal Important Differences. P-values <0.05 were considered statistically significant.Results: In multivariate analysis, only the urinary incontinence DSS remained statistically (P < 0.05) and clinically significantly greater after BT+ than EBRT (90 vs. 83). The number of men with moderate/big urinary or bowel problems was halved after BT+ (P < 0.05). The number of patients with impaired PCS (score < 45) were lower in the BT+ group than the EBRT group (P = 0.02). Regression analysis showed that decreasing levels of bowel and urinary irritation/obstructive DSSs predicted worsening of PCS (P < 0.001) and MCS (P = 0.007), respectively.Conclusions: Dose-escalated radiotherapy by BT did not negatively impact long-term adverse effects, substantial problems or QoL compared with EBRT. Future randomised studies using improved EBRT techniques are needed.
The impact of severe depression on the survival of older patients with end-stage kidney disease
Authors: Jeon You Hyun , Lim Jeong-Hoon , Jeon Yena , Chung Yu-Kyung , Kim Yon Su , Kang Shin-Wook , Yang Chul Woo , Kim Nam-Ho , Jung Hee-Yeon , Choi Ji-Young , Park Sun-Hee , Kim Chan-Duck , Kim Yong-Lim , Cho Jang-Hee
Published: August 2023

Background: Incidence of depression increases in patients with end-stage kidney disease (ESKD). We evaluated the association between depression and mortality among older patients with ESKD, which has not been studied previously. Methods: This nationwide prospective cohort study included 487 patients with ESKD aged >65 years, who were categorized into minimal, mild-to-moderate, and severe depression groups based on their Beck Depression Inventory-II (BDI-II) scores. Predisposing factors for high BDI-II scores and the association between the scores and survival were analyzed. Results: The severe depression group showed a higher modified Charlson comorbidity index value and lower serum albumin, phosphate, and uric acid levels than the other depression groups. The Kaplan-Meier curve revealed a significantly lower survival in the severe depression group than in the minimal and mild-to-moderate depression groups (p = 0.011). Multivariate Cox regression analysis confirmed that severe depression was an independent risk factor for mortality in the study cohort (hazard ratio, 1.39; 95% confidence interval, 1.01–1.91; p = 0.041). Additionally, BDI-II scores were associated with modified Charlson comorbidity index (p = 0.009) and serum albumin level (p = 0.004) in multivariate linear regression. Among the three depressive symptoms, higher somatic symptom scores were associated with increased mortality. Conclusion: Severe depression among older patients with ESKD increases mortality compared with minimal or mild-to-moderate depression, and patients with concomitant somatic symptoms require careful management of their comorbidities and nutritional status.