bluuebunny/crossref_metadata_2025 huggingface dataset:
Narrowing the Relationship between Human CCR5 Gene Polymorphisms and Chagas Disease: Systematic Review and Meta-Analysis
Authors: Ferreira Jean Moisés , Santos Barbara Rayssa Correia dos , Moura Edilson Leite de , Santos Ana Caroline Melo dos , Vencioneck Dutra Jean Carlos , Figueiredo Elaine Virgínia Martins de Sousa , Lima Filho José Luiz de
Published: August 2023

Our aim was to carry out a qualitative and quantitative synthesis of the influence of CCR5 genetic variants on Chagas disease (CD) through a systematic review. A total of 1197 articles were analyzed, and eleven were included in the review. A meta-analysis was conducted along with principal component analyses (PCAs). The polymorphisms found were analyzed using the SNP2TFBS tool to identify possible variants that influence the interaction with gene binding sites. Eleven studied variants were identified: rs2856758, rs2734648, rs1799987, rs1799988, rs41469351, rs1800023, rs1800024, Δ32/rs333, rs3176763, rs3087253 and rs11575815. The studies analyzed were published between 2001 and 2019, conducted in Argentina, Brazil, Spain, Colombia and Venezuela, and included Argentine, Brazilian, Colombian, Peruvian and Venezuelan patients. Eight polymorphisms were subjected to the meta-analysis, of which six were associated with the development of the cardiac form of CD: rs1799987—G/G and G/A in the dominance model and G/G in the recessiveness model; rs2856758—A/G in the codominance model; rs2734648—T/T and T/G in the dominance model; rs1799988—T/T in both the codominance and recessiveness models; rs1800023—G allele and the G/G genotype in the codominance and recessiveness models, and the G/G and G/A genotypes in the dominance model; and rs1800024—T allele. The PCA analyses were able to indicate the relationships between the alleles and the genotypes of the polymorphisms. The SNP2TFBS tool identified rs1800023 as an influencer of the Spi1 transcription factor (p < 0.05). A correlation was established between the alleles associated with the cardiac form of CD in this review, members of the C haplotype of the gene (HHC–TGTG), and the cardiac form of CD.
A Screening Proposal for Zoom Dysmorphia in Virtual Settings
Authors: Türk Cemre Büşra , Mirza Fatima N. , Kroumpouzos George
Published: August 2023

Zoom dysmorphia (ZD) is a facial dysmorphia that is triggered or aggravated by frequent virtual meetings. The frequent use of videoconferencing platforms has been linked to a distorted perception of facial images as individuals have an increased awareness of their appearance, given constant video feedback. As a result, dysmorphic concerns can develop. It is crucial to identify ZD as this condition interferes with an individual’s life and can trigger or aggravate body dysmorphic disorder (BDD). A standardized approach for screening ZD in non-psychiatric settings has yet to be defined. We discuss the features of ZD and the challenges of screening for ZD in a virtual setting. To facilitate the recognition of ZD in telehealth consultations, we propose a comprehensive ZD screening questionnaire that includes questions related to typical ZD features and a BDD-focused question. The questionnaire is concise and allows the identification of individuals with a potential ZD. A BDD assessment in such individuals should follow.
An Inspection Technique for Steel Pipes Wall Condition Using Ultrasonic Guided Helical Waves and a Limited Number of Transducers
Authors: Raišutis Renaldas , Tumšys Olgirdas , Žukauskas Egidijus , Samaitis Vykintas , Draudvilienė Lina , Jankauskas Audrius
Published: August 2023

This research utilizes Ultrasonic Guided Waves (UGW) to inspect corrosion-type defects in steel pipe walls, providing a solution for hard-to-reach areas typically inaccessible by traditional non-destructive testing (NDT) methods. Fundamental helical UGW modes are used, allowing the detection of defects anywhere on the pipe’s circumference using a limited number of transducers and measurements on the upper side of the pipe. Finite element (FE) modeling and experiments investigated generating and receiving UGW helical waves and their propagation through varying corrosion-type defects. Defect detection is based on phase delay differences in the helical wave’s signal amplitude peaks between defective and defect-free regions. Phase delay variations were noted for the different depths and spatial dimensions of the defects. These results highlight the phase delay method’s potential for NDT pipeline inspection.
Freeze–Thaw Durability of Basalt Fibre Reinforced Bio-Based Unsaturated Polyester Composite
Authors: Shahid Abu T. , Hofmann Mateus , Garrido Mário , Correia João R. , Rosa Inês C.
Published: August 2023

This paper presents an experimental study of the wet freeze–thaw (FT) durability of a fibre–polymer composite produced by vacuum infusion using an innovative bio-based unsaturated polyester resin (UPR) and basalt fibres. As the benchmark, an equivalent composite produced with a conventional (oil-based) UPR was also tested. The composites were preconditioned in water immersion for 30 days at 20 °C followed by exposure to wet FT for up to 300 cycles; each FT cycle consisted of 3 h in dry freezing condition (−20 °C) and 8 h in thawing condition (23 °C) submerged in water. The composites’ properties were assessed after preconditioning and after 100, 200, and 300 FT cycles, through mechanical (tensile, compressive, in-plane shear, interlaminar shear) and thermomechanical (dynamic mechanical analysis) tests. Gravimetric and scanning electron microscope analyses were also carried out. The results obtained show that the preconditioning stage, involving water immersion, caused most of the damage, with property reductions of 5% to 39% in the bio-composite, while in the oil-composite they ranged between 4% and 22%, being higher for matrix-dominated properties. On the other hand, FT alone had an insignificant effect on the degradation of material properties; after exposure to FT, property recovery was observed, specifically in matrix-dominated properties, such as interlaminar shear strength, which recovered by 12% in the bio-composite during exposure to FT. The overall performance of the bio-composite was inferior to the conventional one, especially during the preconditioning stage, and this was attributed to the hydrophilicity of some of the components of its bio-based resin.
A New 3D Mathematical Model for Simulating Nanofluid Flooding in a Porous Medium for Enhanced Oil Recovery
Authors: Al-Yaari Abdullah , Ling Chuan Ching Dennis , Sakidin Hamzah , Sundaram Muthuvalu Mohana , Zafar Mudasar , Haruna Abdurrashid , Merican Aljunid Merican Zulkifli , Azad Abdus Samad
Published: August 2023

Two-phase Darcy’s law is a well-known mathematical model used in the petrochemical industry. It predicts the fluid flow in reservoirs and can be used to optimize oil production using recent technology. Indeed, various models have been proposed for predicting oil recovery using injected nanofluids (NFs). Among them, numerical modeling is attracting the attention of scientists and engineers owing to its ability to modify the thermophysical properties of NFs such as density, viscosity, and thermal conductivity. Herein, a new model for simulating NF injection into a 3D porous media for enhanced oil recovery (EOR) is investigated. This model has been developed for its ability to predict oil recovery across a wide range of temperatures and volume fractions (VFs). For the first time, the model can examine the changes and effects of thermophysical properties on the EOR process based on empirical correlations depending on two variables, VF and inlet temperature. The governing equations obtained from Darcy’s law, mass conservation, concentration, and energy equations were numerically evaluated using a time-dependent finite-element method. The findings indicated that optimizing the temperature and VF could significantly improve the thermophysical properties of the EOR process. We observed that increasing the inlet temperature (353.15 K) and volume fraction (4%) resulted in better oil displacement, improved sweep efficiency, and enhanced mobility of the NF. The oil recovery decreased when the VF (>4%) and temperature exceeded 353.15 K. Remarkably, the optimal VF and inlet temperature for changing the thermophysical properties increased the oil production by 30%.
Enhancement of Hydrogen Adsorption on Spray-Synthesized HKUST-1 via Lithium Doping and Defect Creation
Authors: Kubo Masaru , Matsumoto Tomoki , Shimada Manabu
Published: August 2023

We prepared HKUST-1 (Cu3BTC2; BTC3− = 1,3,5-benzenetricarboxylate) using a spray synthesis method with Li doping and defect created via partial replacement of H3BTC with isophthalic acid (IP) to enhance the H2 adsorption capacity. Li-doping was performed by incorporating LiNO3 in HKUST-1 via spray synthesis and subsequent thermal treatment for decomposing NO3−, which enhances H2 uptake at 77 K and 1 bar per unit mass and per unit area from 2.37 wt% and 4.16 molecules/nm2 for undoped HKUST-1 to 2.47 wt% and 4.33 molecules/nm2, respectively. Defect creation via the replacement of the BTC3− linker with the IP2− linker slightly in HKUST-1 skeleton did not affect H2 uptake. Both Li-doping and defect creation significantly enhanced H2 uptake to 3.03 wt%, which was caused by the coordination of Li ions with free carboxylic groups of the created defects via IP replacement.
Silicon-Based Superslippery/Superhydrophilic Striped Surface for Highly Efficient Fog Harvesting
Authors: Ji Xiang , Shuai Shunxu , Liu Shuai , Weng Yuyan , Zheng Fengang
Published: August 2023

Fog-harvesting performance is influenced by surface wettability, patterned structure and the heat transfer coefficient. In this work, we have prepared different surfaces with a stripe array of superhydrophilic, superslippery and superslippery/superhydrophilic surfaces for fog harvesting on silicon substrates using photolithography and silver-assisted chemical etching. The surface wettability and heat transfer coefficients of the above samples have been investigated. We analyzed the contact angle, sliding angle and transport state of droplets on these surfaces. The fog-harvesting rate of all samples under different voltages of the cooling pad (V = 0, 2.0, 2.5, 3.0, 3.5 V) was measured. Results showed that the superslippery/superhydrophilic striped surface could achieve rapid droplet nucleation, directional transport and efficient collection due to its superhydrophilic striated channels and the Laplace pressure difference between different wettability regions. At a condensation voltage of 3.5 V, the fog-harvesting rate efficiencies of the uniformly striped superhydrophilic and superslippery surface were 1351 mg·cm−2·h−1 and 1265 mg·cm−2·h−1, respectively, while the fog-harvesting rate of the superslippery/superhydrophilic striped surface was 1748 mg·cm−2·h−1. Compared with the original silicon surface, the maximum fog-harvesting rate of the superslippery/superhydrophilic striped surface was improved by 86.9%. This study offers significant insights into the impact of heat transfer and silicon surface wettability on the process of fog collection.
Effect of Ultrasonic Frequency on Structure and Corrosion Properties of Coating Formed on Magnesium Alloy via Plasma Electrolytic Oxidation
Authors: Fatimah Siti , Hazmatulhaq Farah , Sheng Yujun , Suhartono Tri , Oh Jeong Moo , Nashrah Nisa , Kang Jee-Hyun , Ko Young Gun
Published: August 2023

This study explores the application of ultrasonic vibration during plasma electrolytic oxidation (PEO) to enhance the corrosion resistance of magnesium (Mg) alloy. To this end, three different ultrasonic frequencies of 0, 40, and 135 kHz were utilized during PEO. In the presence of ultrasonic waves, the formation of a uniform and dense oxide layer on Mg alloys is facilitated. This is achieved through plasma softening, acoustic streaming, and improved mass transport for successful deposition and continuous reforming of the oxide layer. The oxide layer exhibits superior protective properties against corrosive environments due to the increase in compactness. Increasing ultrasonic frequency from 40 to 135 kHz, however, suppresses the optimum growth of the oxide layer due to the occurrence of super-soft plasma swarms, which results in a low coating thickness. The integration of ultrasonic vibration with PEO presents a promising avenue for practical implementation in industries seeking to enhance the corrosion protection of Mg alloys, manipulating microstructures and composition.
The Effect of Alkali Metals (Li, Na, and K) on Ni/CaO Dual-Functional Materials for Integrated CO2 Capture and Hydrogenation
Authors: Hu Yong , Xu Qian , Sheng Yao , Wang Xueguang , Cheng Hongwei , Zou Xingli , Lu Xionggang
Published: August 2023

Ni/CaO, a low-cost dual-functional material (DFM), has been widely studied for integrated CO2 capture and hydrogenation. The core of this dual-functional material should possess both good CO2 capture–conversion performance and structural stability. Here, we synthesized Ni/CaO DFMs modified with alkali metals (Na, K, and Li) through a combination of precipitation and combustion methods. It was found that Na-modified Ni/CaO (Na-Ni/CaO) DFM offered stable CO2 capture–conversion activity over 20 cycles, with a high CO2 capture capacity of 10.8 mmol/g and a high CO2 conversion rate of 60.5% at the same temperature of 650 °C. The enhanced CO2 capture capacity was attributed to the improved surface basicity of Na-Ni/CaO. In addition, the incorporation of Na into DFMs had a favorable effect on the formation of double salts, which shorten the CO2 capture and release process and promoted DFM stability by hindering their aggregation and the sintering of DFMs.
The Shear Bond Strength of Resin-Based Luting Cement to Zirconia Ceramics after Different Surface Treatments
Authors: Sokolowski Grzegorz , Szczesio-Wlodarczyk Agata , Szynkowska-Jóźwik Małgorzata Iwona , Stopa Wioleta , Sokolowski Jerzy , Kopacz Karolina , Bociong Kinga
Published: August 2023

Due to its unique properties, zirconia is increasingly being used in dentistry, but surface preparation for bonding is difficult because of its polycrystalline structure. This study aimed to determine the effect of a new etching technique (Zircos-E) on Ceramill Zi (Amann Girrbach). The effect of etching and the use of primers (Monobond Plus and MKZ Primer) on the bond strength of zirconia with resin cement (NX3) was assessed. Shear bond strength was evaluated after storage in water for 24 h and after thermal aging (5000 thermocycling at 5 °C/55 °C). A scanning electron microscope (Hitachi S-4700) was used to evaluate the surface structure before and after the Zircos-E system. The roughness parameters were assessed using an SJ-410 profilometer. The etched zirconia surface is more homogeneous over the entire surface, but some localized forms of erosion exist. The etching of zirconia ceramics caused changes in the surface structure of zirconia and a significant increase in the shear bond strength between zirconia and resin cement. The use of primers positively affects the adhesion between resin cement and zirconia. Aging with thermocycler significantly reduced the shear bond strength, with one exception—sandblasted samples with MKZ Primer. Standard ceramic surface preparation, involving only alumina sandblasting, does not provide a satisfactory bond. The use of etching with the Zircos-E system and primers had a positive effect on the strength of the zirconium–resin cement connection.
Building a Digital Twin Powered Intelligent Predictive Maintenance System for Industrial AC Machines
Authors: Singh R. Raja , Bhatti Ghanishtha , Kalel Dattatraya , Vairavasundaram Indragandhi , Alsaif Faisal
Published: August 2023

Predictive maintenance is a system’s competency in distinguishing future scenarios where the machine is likely to fail and schedule repairs just prior to this happening. A heuristic technology to enable efficient predictive maintenance is digital twin technology. The development of a twin system between real-time machinery and the virtual world is made possible by digital twin technology, which is ideal for predictive maintenance. Induction motors, which are the core of industrial machinery, are sparsely represented in the digital twin domain. Therefore, this study created a digital twin of a squirrel cage induction motor, utilizing data-driven modeling and multiple physics, and integrated it with a custom predictive maintenance system. The purpose of this study is to implement digital twin technology for induction motors for fault diagnosis and predictive maintenance. This framework can extrapolate running parameters to presciently detect motor remaining useful lifetime as well as erratic fault diagnosis. The experimental setup for the 2.2 kW squirrel cage induction motor has been integrated into the digital workspace via the dSPACE MicroLabBox controller to allow frequent calibration and reference signal setup. The resultant digital framework deployed on MATLAB Simulink provided high accuracy without placing a great computational load on the processor. The proposed model’s commercial application may open the way for computational intelligence in Industry 4.0 adoption of induction motors.
Robust H∞ Performance Analysis of Uncertain Large-Scale Networked Systems
Authors: Guan Rongxing , Liu Huabo
Published: August 2023

This paper considers the robust H∞ performance problem of continuous-time uncertain large-scale networked systems (LSNSs). The systems consist of numerous arbitrarily connected subsystems, each of which has different dynamics. Currently it is computationally difficult to manage systems with the existing lumped analysis method; therefore, exploiting the structural properties of the systems, sufficient conditions are derived for robust H∞ performance. Based on these results, an analysis condition that depends only on the parameters of each single subsystem is further obtained. Some numerical simulations are proposed to verify the validity and superiority of the developed conditions.
Analysis of Psychological Factors Influencing Mathematical Achievement and Machine Learning Classification
Authors: Park Juhyung , Kim Sungtae , Jang Beakcheol
Published: August 2023

This study analyzed the psychological factors that influence mathematical achievement in order to classify students’ mathematical achievement. Here, we employed linear regression to investigate the variables that contribute to mathematical achievement, and we found that self-efficacy, math-efficacy, learning approach motivation, and reliance on academies affect mathematical achievement. These variables are derived from the Test of Learning Psychology (TLP), a psychological test developed by Able Edutech Inc. specifically to measure students’ learning psychology in the mathematics field. We then conducted machine learning classification with the identified variables. As a result, the random forest model demonstrated the best performance, achieving accuracy values of 73% (Test 1) and 81% (Test 2), with F1-scores of 79% (Test 1) and 82% (Test 2). Finally, students’ skills were classified according to the TLP items. The results demonstrated that students’ academic abilities could be identified using a psychological test in the field of mathematics. Thus, the TLP results can serve as a valuable resource to develop personalized learning programs and enhance students’ mathematical skills.
The Composite Grid Method for Singular Problems of Partial Differential Equations
Authors: Ye Hai , Xie Yajun
Published: August 2023

Partial differential equations are crucial in scientific computing, and this paper will consider some of the problems of partial differential equation singularities. The Composite Mesh Method (CGM) is a new and improved numerical method for solving partial differential equations based on existing numerical methods for finite elements. The method has two meshes over the entire domain—a coarse and a fine set. The two sets of meshes generated by Mesh3 are separate in their respective regions and do not nest or interact. This method improves the accuracy of solving the numerical solution of partial differential equations. This paper discusses the CGM method based on the Finite Element Program Generator (FEPG) and uses it to simulate several singular problems. The numerical simulation results show that the proposed method can obtain more satisfactory simulation results for global problems and use a smaller number of computational generations than the general finite element method.
In Silico Analysis of the Effect of Hydrastis canadensis on Controlling Breast Cancer
Authors: Vyshnavi AM Hima , Sankaran Sathianarayanan , Namboori PK Krishnan , Venkidasamy Baskar , Hirad Abdurahman , Alarfaj Abdullah , Vinayagam Ramachandran
Published: August 2023

Background and Objectives: Breast cancer is a significant type of cancer among women worldwide. Studies have reported the anti-carcinogenic activity of Hydrastis Canadensis (Goldenseal) in cancer cell lines. Hydrastis Canadensis could help eliminate toxic substances due to its anti-cancer, anti-inflammatory, and other properties. The design phase includes the identification of potential and effective molecules through modern computational techniques. Objective: This work aims to study Hydrastis Canadensis’s effect in controlling hormone-independent breast cancer through in-silico analysis. Materials and Methods: The preliminary screening of reported phytochemicals includes biomolecular networking. Identifying functionally relevant phytochemicals and the respective target mutations/genes leads to selecting 3D proteins of the desired mutations being considered the target. Interaction studies have been conducted using docking. The kinetic and thermodynamic stability of complexes was studied through molecular dynamic simulation and MM-PBSA/GBSA analysis. Pharmacodynamic and pharmacokinetic features have been predicted. The mechanism-wise screening, functional enrichment, and interactional studies suggest that canadaline and Riboflavin effectively interact with the target proteins. Results: Hydrastis Canadensis has been identified as the effective formulation containing all these constituents. The phytoconstituents; Riboflavin and Canadensis showed good interaction with the targets of hormone-independent breast cancer. The complexes were found to be kinetically and thermodynamically stable. Conclusions: Hydrastis Canadensis has been identified as effective in controlling ‘hormone-independent or basal-like breast cancer’ followed by ‘hormone-dependent breast cancer: Luminal A’ and Luminal B.
Assessing Repeated Urinary Proline Betaine Measures as a Biomarker of Usual Citrus Intake during Pregnancy: Sources of Within-Person Variation and Correlation with Reported Intake
Authors: French Caitlin D. , Arnold Charles D. , Taha Ameer Y. , Engle-Stone Reina , Schmidt Rebecca J. , Hertz-Picciotto Irva , Slupsky Carolyn M.
Published: August 2023

Proline betaine (Pro-B) has been identified as a biomarker of dietary citrus intake, yet gaps remain in its validation as a quantitative predictor of intake during various physiological states. This study quantified sources of within-individual variation (WIV) in urinary Pro-B concentration during pregnancy and assessed its correlation with the reported usual intake of citrus fruit and juice. Pro-B concentrations were determined by 1H-NMR spectroscopy in spot and 24-h urine specimens (n = 255) collected throughout pregnancy from women participating in the MARBLES cohort study. Adjusted linear or log mixed effects models quantified WIV and tested potential temporal predictors of continuous or elevated Pro-B concentration. Pearson or Spearman correlations assessed the relationship between averaged repeated biomarker measures and usual citrus intake reported by food frequency questionnaires. The proportion of variance in urinary Pro-B attributable to WIV ranged from 0.69 to 0.74 in unadjusted and adjusted models. Citrus season was a significant predictor of Pro-B in most analyses (e.g., adjusted β [95% CI]: 0.52 [0.16, 0.88] for non-normalized Pro-B), while gestational age predicted only non-normalized Pro-B (adjusted β [95% CI]: −0.093 [−0.18, −0.0038]). Moderate correlations (rs of 0.40 to 0.42) were found between reported usual citrus intake and averaged repeated biomarker measurements, which were stronger compared to using a single measurement. Given the high degree of WIV observed in urinary Pro-B, multiple samples per participant are likely needed to assess associations between citrus consumption and health outcomes.
Leptospira Status in Sweden during the Past Century, Neglected and Re-Emerging?
Authors: Strand Tanja M. , Olsson Engvall Eva , Lahti Elina , Hjertqvist Marika , Lundkvist Åke
Published: August 2023

We compiled data on notified cases of leptospirosis in animals and humans in Sweden. Published studies on leptospirosis in humans and animals from the beginning of the 20th century onwards are summarized. During the Second World War, hundreds of leptospirosis cases in humans were reported in Sweden, but since then, there have been only a few severe cases. Surveillance of leptospirosis in domestic animals demonstrates that the pathogen is still occurring. The occurrence of Leptospira in humans and animals in the other Nordic countries resembles that in Sweden. Leptospirosis is an underdiagnosed and underreported disease globally, both in animals and humans, partly due to the lack of simple, rapid diagnostic tools but possibly also due to the lack of awareness among physicians, veterinarians and nurses. Traditionally, leptospirosis has been mostly diagnosed by serology, but development of molecular methodshas improved the capability for correct diagnosis. As of today, leptospirosis is regarded as a relatively uncommon disease in the Nordic countries, but in some other countries, it is considered a neglected zoonosis or a (re-)emerging disease that may become more common in the future. Possible factors that could contribute to an increase in incidence are discussed in this review. Active surveillance of humans and domestic and wild animals and stringent rodent control in society and animal farms are of outmost importance for prevention.
Stimulation of the Defense Mechanisms of Potatoes to a Late Blight Causative Agent When Treated with Bacillus subtilis Bacteria and Chitosan Composites with Hydroxycinnamic Acids
Authors: Yarullina Liubov , Cherepanova Ekaterina A. , Burkhanova Guzel F. , Sorokan Antonina V. , Zaikina Evgenia A. , Tsvetkov Vyacheslav O. , Mardanshin Ildar S. , Fatkullin Ildus Y. , Kalatskaja Joanna N. , Yalouskaya Ninel A. , Nikalaichuk Victoria V.
Published: August 2023

Phytophthora infestans is, worldwide, one of the main causal agents of epiphytotics in potato plantings. Prevention strategies demand integrated pest management, including modeling of beneficial microbiomes of agroecosystems combining microorganisms and natural products. Chitooligosaccharides and their derivatives have great potential to be used by agrotechnology due to their ability to elicit plant immune reactions. The effect of combining Bacillus subtilis 26D and 11VM and conjugates of chitin with hydroxycinnamates on late blight pathogenesis was evaluated. Mechanisms for increasing the resistance of potato plants to Phytophthora infestans were associated with the activation of the antioxidant system of plants and an increase in the level of gene transcripts that encode PR proteins: basic protective protein (PR-1), thaumatin-like protein (PR-5), protease inhibitor (PR-6), and peroxidase (PR-9). The revealed activation of the expression of marker genes of systemic acquired resistance and induced systemic resistance under the influence of the combined treatment of plants with B. subtilis and conjugates of chitin with hydroxycinnamates indicates that, in this case, the development of protective reactions in potato plants to late blight proceeds synergistically, where B. subtilis primes protective genes, and chitosan composites act as a trigger for their expression.
Low-Temperature Enhancement-Mode Amorphous Oxide Thin-Film Transistors in Solution Process Using a Low-Pressure Annealing
Authors: Park Won , Park Jun-Hyeong , Eun Jun-Su , Lee Jinuk , Na Jeong-Hyeon , Lee Sin-Hyung , Jang Jaewon , Kang In Man , Kim Do-Kyung , Bae Jin-Hyuk
Published: August 2023

The interest in low processing temperature for printable transistors is rapidly increasing with the introduction of a new form factor in electronics and the growing importance of high throughput. This paper reports the fabrication of low-temperature-processable enhancement-mode amorphous oxide thin-film transistors (TFTs) using the solution process. A facile low-pressure annealing (LPA) method is proposed for the activation of indium oxide (InOx) semiconductors at a significantly low processing temperature of 200 °C. Thermal annealing at a pressure of about ~10 Torr induces effective condensation in InOx even at a low temperature. As a result, the fabricated LPA InOx TFTs not only functioned in enhancement mode but also exhibited outstanding switching characteristics with a high on/off current ratio of 4.91 × 109. Furthermore, the LPA InOx TFTs exhibit stable operation under bias stress compared to the control device due to the low concentration of hydroxyl defects.
Investigation of Structural, Dielectric and Optical Properties of Polyaniline—Magnesium Ferrite Composites
Authors: Kolhar Priyanka , Sannakki Basavaraja , Verma Meenakshi , Suresha Siddaramappa , Alshehri Mansoor , Shah Nehad Ali
Published: August 2023

A study on the influence of magnesium ferrite nanoparticles on the optical and dielectric attributes of Polyaniline has been conducted. Magnesium nano Ferrite powder is synthesized by the self-propagating solution combustion method. Polyaniline–Magnesium nano ferrite composites are synthesized by chemical oxidative polymerization of aniline with the addition of Magnesium nanoparticles. The samples are characterized with XRD and UV-Vis spectrometer, in the wavelength range of 200–800 nm and studied for optical properties. Dielectric properties are studied in the frequency range of 50 Hz to 5 MHz. X-ray diffraction reveals single phase formation of Magnesium ferrite, whereas Polyaniline shows an amorphous nature. In the XRD of the composites, we see the crystalline peaks of ferrite becoming more intense with the addition of ferrite and whereas the peak of Polyaniline diminishes. The crystallite size is quantified with the Debye—Scherrer formula, and it increases as the content of ferrite in the composites increases. The micro-strain decreases in the composites as the percentage of ferrite enhances in the composites. In the UV-Vis absorption spectra of composites, the peaks of Polyaniline shift to higher wavelength and there is also an absorption band in the spectra of composites corresponding to that of Magnesium ferrite particles. Both direct and indirect band gaps are calculated with the Tauc plot, and both the optical band gap decrease as the percentage of ferrite increases in the composite. The dielectric loss and dielectric constant both decrease with frequency in all the samples, and the dielectric response are in good agreement with Maxwell—Wagner model. Ferrite—polymer composites with both conducting and magnetic properties are considered useful for electromagnetic shielding and microwave absorption.
Fabrication of PLA-Based Electrospun Nanofibers Reinforced with ZnO Nanoparticles and In Vitro Degradation Study
Authors: Salaris Valentina , San Félix García-Obregón Iñaki , López Daniel , Peponi Laura
Published: August 2023

In this work, electrospun nanofibers based on polylactic acid, PLA, reinforced with ZnO nanoparticles have been studied, considering the growing importance of electrospun mats based on biopolymers for their applications in different fields. Specifically, electrospun nanofibers based on PLA have been prepared by adding ZnO nanoparticles at different concentrations, such as 0.5, 1, 3, 5, 10 and 20 wt%, with respect to the polymer matrix. The materials have been characterized in terms of their morphological, mechanical, and thermal properties, finding 3 wt% as the best concentration to produce PLA nanofibers reinforced with ZnO nanoparticles. In addition, hydrolytic degradation in phosphate buffer solution (PBS) was carried out to study the effect of ZnO nanoparticles on the degradation behavior of PLA-based electrospun nanofiber mats, obtaining an acceleration in the degradation of the PLA electrospun mat.
Investigating the Predictive Value of Thyroid Hormone Levels for Stroke Prognosis
Authors: Gkantzios Aimilios , Karapepera Vaia , Tsiptsios Dimitrios , Liaptsi Eirini , Christidi Foteini , Gkartzonika Elena , Karatzetzou Stella , Kokkotis Christos , Kyrtsopoulos Mihail , Tsiakiri Anna , Bebeletsi Paschalina , Chaidemenou Sofia , Koutsokostas Christos , Tsamakis Konstantinos , Baltzi Maria , Mpalampanos Dimitrios , Aggelousis Nikolaos , Vadikolias Konstantinos
Published: August 2023

Given the expansion of life expectancy, the aging of the population, and the anticipated rise in the number of stroke survivors in Europe with severe neurological consequences in the coming decades, stroke is becoming the most prevalent cause of functional disability. Therefore, the prognosis for a stroke must be timely and precise. Two databases (MEDLINE and Scopus) were searched to identify all relevant studies published between 1 January 2005 and 31 December 2022 that investigated the relationship between thyroid hormone levels and acute stroke severity, mortality, and post-hospital prognosis. Only full-text English-language articles were included. This review includes Thirty articles that were traced and incorporated into the present review. Emerging data regarding the potential predictive value of thyroid hormone levels suggests there may be a correlation between low T3 syndrome, subclinical hypothyroidism, and poor stroke outcome, especially in certain age groups. These findings may prove useful for rehabilitation and therapy planning in clinical practice. Serum thyroid hormone concentration measurement is a non-invasive, relatively harmless, and secure screening test that may be useful for this purpose.
A Three-Arm, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety of Lactobacillus salivarius AP-32 and Bifidobacterium animalis CP-9 Used Individually in Healthy Infants
Authors: Chen Jui-Fen , Ou-Yang Mei-Chen , Hsia Ko-Chiang ,   Neonatal Probiotic Use and Safety Research Group, Li Ching-Min , Yeh Yao-Tsung , Ho Hsieh-Hsun
Published: August 2023

Probiotics are considered safe and beneficial to human health. However, the safety of Lactobacillus salivarius AP-32 and Bifidobacterium animalis CP-9 in infants has not been confirmed. This study was to assess the safety of long-term oral administration of L. salivarius AP-32 and B. animalis CP-9 in healthy infants compared with placebo. A three-arm, randomized, double-blind, placebo-controlled trial was conducted in healthy, full-term infants. Eighty-eight infants between 7 days and 2 months (60 ± 7 days) of age were selected and randomized to treatment with L. salivarius AP-32, B. animalis CP-9 or placebo for 4 months. The unblinding indicated subjects were randomized to receive B. animalis CP-9 (N = 28), L. salivarius AP-32 (N = 29), or placebo (N = 31). A total of 76 infants completed the 4-month treatment with fully compliance. The primary outcome was weight gain, with no significant difference in infant weight at 4 months when comparing AP-32 or CP-9 group with the placebo group, either. The head circumference and recumbent length of the CP-9 group were not significantly different from those of the placebo group. The recumbent length of the AP-32 group was slightly lower than that in the placebo group at month 4, but there was no difference between the two groups in head circumference. Overall, the growth trend of all treatments was similar without significant difference. Furthermore, there were no apparent differences between each group in digestive tolerance, the occurrence of adverse events, crying/fussing time and episodes, alpha diversity, and beta diversity. The CP-9 group showed a significant increase in the abundance of the Bacteroides genus, while the AP-32 group demonstrated a significant increase in the abundance of the Lactobacillus genus when comparing the two probiotic groups. Our study findings indicate that the oral administration of both AP-32 and CP-9 strains has a positive impact on the maintenance of a healthy gut flora in infants. Long-term use of L. salivarius AP-32 or B. animalis CP-9 is safe for infants from 7 days to 6 months of age.
Time-Restricted Feeding and Weight Loss in Obesity: A Mini Review on the Impacts on Skeletal Muscle Mass
Authors: Ferri Antonio Guilherme Correia , Ramos da Silva Adelino Sanchez , De Freitas Ellen Cristini , Pauli José Rodrigo
Published: August 2023

Across the globe, obesity is a significant concern for public health, a disease characterized by excessive accumulation of body fat, with a negative impact on health. Time-restricted feeding (TRF), in which food accessibility is restricted to a variable period of 8–10 h, especially in the active phase, inducing a prolonged fasting period, is a strategy with potential effects in preventing obesity. Evidence in preclinical studies demonstrated that TRF attenuates the impacts of metabolic disturbances related to high-fat diet feeding in rodents. Through these discoveries, there has been growing interest in revealing the effects associated with TRF in preventing obesity and its comorbidities, as well as investigating its effects in humans. Although TRF is a promising alternative to reduce the impact of obesity, it is necessary to investigate the results on skeletal muscle tissue. Muscle tissue is important for body energy expenditure; however, caloric restriction can negatively impact protein turnover and induce loss of muscle mass, influencing the basal metabolic rate and weight loss. This mini review examined the scientific literature exploring the effects of time-restricted feeding (TRF) on muscle mass. Although still incipient, the findings related to TRF applied to obese individuals highlight the importance of carrying out dietary control, as well as the consumption and fractionation of proteins, to maintain a balanced protein turnover and, consequently, muscle mass.
Large-Range Switchable Asymmetric Transmission and Circular Conversion Dichroism in a VO2 Based Metasurface
Authors: Zhao Songliang , Jiang Huan , Wang Jingyu , Zhu Wenchang , Zhao Weiren
Published: August 2023

Reconfigurable chiral metasurfaces with a dynamic polarization manipulation capability are highly required in optical integrated systems. In this paper, we simultaneously realized giant and large-range switchable asymmetric transmission (AT) and circular conversion dichroism (CCD) in a vanadium dioxide (VO2) based metasurface. The AT and CCD of the insulator VO2 based metasurface reached 0.95 and 0.92, respectively. Utilizing the insulator-to-metallic phase transition of VO2, the AT and CCD could be continuously switched to near zero. Furthermore, the physics mechanism of the giant and switchable AT and CCD were analyzed. The proposed metasurface with large-range switchable AT and CCD is promising in applications of biochemistry detection, chiral imaging, and biosensing.
Evaluation of Trichoderma spp. on Fusarium oxysporum f. sp. asparagi and Fusarium wilt Control in Asparagus Crop
Authors: Brizuela Alexandri María , Gálvez Laura , Arroyo Juan Manuel , Sánchez Silvia , Palmero Daniel
Published: August 2023

Among the key diseases affecting the asparagus crop (Asparagus officinalis L.), vascular wilting of asparagus caused by Fusarium oxysporum f. sp. asparagi stands out worldwide. This disease significantly shortens the longevity of the crop and limits economic production. Traditional control measures have been largely ineffective, and chemical control methods are difficult to apply, making biological control approaches, specifically the use of Trichoderma, an economical, effective, and risk-free alternative. This study aimed to identify the main factors that affect the efficacy of biopesticides studied as Biological Control Agents (BCAs) against Fusarium wilt in asparagus and to assess the efficacy of Trichoderma-based biopesticides under greenhouse and semi-field conditions. We evaluated the response of three Trichoderma spp. (T. atroviride, T. asperellum, and T. saturnisporum) to environmental variables, such as temperature and water activity, and their antagonistic capacity against Fusarium oxysporum f. sp. asparagi. All three Trichoderma species inhibited the growth of the pathogen in vitro. A decrease in water activity led to a greater reduction in the growth rate. The efficacy of the three biological control agents decreased with higher temperatures, resulting in minimal inhibition, particularly under conditions of restricted available water in the environment. The effect of the fungal inoculum density was also analyzed at two different temperatures. A direct correlation between the amount of inoculum and the score on the Disease Severity Index (DSI) was observed. A notable reduction in DSI was evident in treatments with high inoculum density (106 conidium/mL) for all three species of Trichoderma tested at both temperatures. In greenhouse and semi-field tests, we observed less disease control than expected, although T. asperellum and T. atroviride showed lower disease severity indices and increased the dry weight of seedlings and crowns, whereas T. saturnisporum resulted in the highest disease rate and lowest dry weight. This work highlights that the efficacy of Trichoderma as BCAs is influenced by various factors, including the quantity of soil inocula, and environmental conditions. The study findings have strong implications for selecting appropriate Trichoderma species for controlling specific pathogens under specific environmental conditions.
Revealing the Impact of Micro-SiO2 Filer Content on the Anti-Corrosion Performance of Water-Borne Epoxy Resin
Authors: Fan Bifeng , Yang Junjie , Cao Lin , Wang Xiao , Li Jie , Yang Yingfei , Wang Qiwei , Zhang Peng , Vogel Florin , Li Wei , Lin Zhidan
Published: August 2023

Due to green development in recent years, water-borne epoxy resins (WBE) have become increasingly popular since they generate the lowest level of volatile organic compounds (VOC) during curing. However, because of the large surface tension of water, it is easy to produce voids and cracks during the curing process of the coating. An electrochemical strategy was used in this study to assess the impact of different SiO2 content on the corrosion performance of a WBE coating, in which micron spherical SiO2 particles were synthesized in a liquid phase reduction. The results showed that the synthesized micron spherical SiO2 particles were about 800 ± 50 nm in diameter and in an amorphous state. By hydrophilizing the surfaces of these SiO2 particles, uniform dispersion in an aqueous solvent and a WBE can be achieved. It is important to note that adding a small or excessive amount of SiO2 to a coating will not improve corrosion resistance and may even reduce corrosion resistance. With the appropriate modification of SiO2, corrosion resistance of composite coatings is greatly enhanced, as is the adhesion between the coatings and the metallic substrates. Because the appropriately modified SiO2 can effectively fill the pores that are formed during the curing process, a corrosive medium is less likely to react with the matrix when the medium comes into contact with the matrix. Based on their incorporation content of 3 wt.%, their corrosion resistance is the best after 16 cycles of AC-DC-AC accelerated corrosion tests.
Preparation and Characterization of Hydrogel Films and Nanoparticles Based on Low-Esterified Pectin for Anticancer Applications
Authors: Patlay Aleksandra A. , Belousov Andrei S. , Silant’ev Vladimir E. , Shatilov Roman A. , Shmelev Mikhail E. , Kovalev Valeri V. , Perminova Irina V. , Baklanov Ivan N. , Kumeiko Vadim V.
Published: August 2023

Prospective adjuvant anticancer therapy development includes the establishing of drug delivery systems based on biocompatible and biodegradable carriers. We have designed films and nanoparticles (NPs) based on low-esterified pectin hydrogel using the ionic gelation method. We investigated morphology, nanomechanical properties, biocompatibility and anticancer activity. Hydrogel films are characterized by tunable viscoelastic properties and surface nanoarchitectonics through pectin concentration and esterification degree (DE), expressed in variable pore frequency and diameter. An in vitro study showed a significant reduction in metabolic activity and the proliferation of the U87MG human glioblastoma cell line, probably affected via the adhesion mechanism. Glioma cells formed neurosphere-like conglomerates with a small number of neurites when cultured on fully de-esterified pectin films and they did not produce neurites on the films prepared on 50% esterified pectin. Pectin NPs were examined in terms of size distribution and nanomechanical properties. The NPs’ shapes were proved spherical with a mean diameter varying in the range of 90–115 nm, and a negative zeta potential from −8.30 to −7.86 mV, which indicated their stability. The NPs did not demonstrate toxic effect on cells or metabolism inhibition, indicating good biocompatibility. Nanostructured biomaterials prepared on low-esterified pectins could be of interest for biomedical applications in adjuvant anticancer therapy and for designing drug delivery systems.
Mineralogical Characteristics and Arsenic Release of High Arsenic Coals from Southwestern Guizhou, China during Pyrolysis Process
Authors: Gong Bengen , Tian Chong , Wang Xiang , Chen Xiaoxiang , Zhang Junying
Published: August 2023

Coal is the primary energy source in China, and coal pyrolysis is considered an essential and efficient method for clean coal utilization. Three high arsenic coals collected from the southwestern Guizhou province of China were chosen in this study. Low-temperature ashing plus X-ray diffraction analysis (XRD) was used to identify the minerals in coals. The three coals were pyrolyzed in a tube furnace in an N2 atmosphere at 950 °C, 1200 °C, and 1400 °C, respectively. Environment scanning electron microscope (ESEM), XRD, X-ray fluorescence analysis (XRF), and inductively coupled plasma-mass spectrometry (ICP-MS) were adopted to determine the morphology, mineral compositions, and element compositions and arsenic contents of the coal pyrolysis ashes, respectively. It can be found that minerals in coal are mainly composed of quartz, pyrite, muscovite, and rutile. The minerals in the ashes generated from coal pyrolysis mainly contain quartz, dehydroxylated muscovite, iron oxide minerals, mullite, and silicon nitride. Oldhamite and gupeite exist at 950 °C and 1400 °C, respectively. The morphologies of oldhamite and gupeite at these temperatures are irregular block-shaped particles and irregular spherical particles, respectively. The mineralogical transformations in the process of coal pyrolysis affect coal utilization. The arsenic release rate is higher than 87% during pyrolysis at 1400 °C. The arsenic in organic matter is more able to be volatilized than mineral components. The retention time can slightly influence the arsenic release rate, and the influence of temperature is much more significant than the influence of retention time. The understanding of mineral evolution and arsenic environmental emission is helpful for the safety of high-arsenic coal pyrolysis.