bluuebunny/crossref_metadata_2025 huggingface dataset:
Monitoring seasonal variations of haloacetic acids (HAAS) in low-TOC and low-chlorine networks and assessing risk to public health: Muş, Türkiye case
Authors: Edip Avşar  , Adile Kılıç
Published: July 2023

Chlorine not only removes parasitic pathogenic microorganisms in water, but also causes the formation of disinfection by-products (DBPs) that can be carcinogenic to humans, due to  reacting with natural organic matter (NOMs) in raw water sources. Haloacetic acids (HAAs) are one of the most well-known and common disinfection by-product groups (DBPs) in the literature.  In the risk definitions of the EPA, some of its components have been identified as carcinogenic. Therefore, determination of HAA concentration in water and execution of a risk analysis are very important in terms of determining the possible effects on public health. This study aimed to monitor the seasonal and spatial variations of haloacetic acids (HAAs) in 2 different water supplies (surface and groundwater) serving the city center of Muş Province, Türkiye, and to demonstrate their public health implications. In this context, an analytical study was conducted covering 4 seasons. According to the results, although the amount of NOM in water bodies was less than 1 mg‧L−1, the HAA5 content may occasionally exceed the USEPA limits of 60 µg‧L−1, but did not exceed the Canadian 80 µg‧L−1 limit. When the WHO limit values were examined on a component basis, it was determined that the MCAA concentrations in both water sources sometimes exceeded the limit of 20 µg‧L−1 in the July and October sampling periods. The risk level related to maximum DCAA level in the main network by means of ingestion pathway was found to be 18.7 times higher for women and 16.5 times higher for men when compared with USEPA risk criteria. Also, in the Muratpaşa water network, risk from DCAA exceeds the USEPA risk level 15.2-fold in women and 13.4-fold in men. However, since it was also found that the level of free chlorine in the network does not meet the required level, it should be noted that there may be an increase in the risk level if there is adequate chlorination in the supply.
Microscopy-based bead protein-protein interaction assay v1
Authors: Holzer Elisabeth
Published: July 2023

This protocol describes how to perform microscopy-based bead protein-protein interaction assay with GST- or mCherry-tagged proteins as baits and fluorescently-tagged proteins as preys. The protocol requires to have purified proteins and allows to monitor protein-protein interaction in an equilibrium state. The fluorescent signal can be quantified.
Live imaging and analysis to investigate phase separation properties of NEMO during mitophagy v1
Authors: HARDING OLIVIA
Published: July 2023

Phase condensation of biomolecular particles is increasingly examined for its relevance in physiological contexts. When we observed formation of NEMO puncta associated with the outer mitochondrial membrane of damaged mitochondria, we wondered whether these puncta were incorporated into phase separated particles. Three standards of the field for determining phase separation are: (A) particles undergo fission and fusion like droplets of water, (B) individual puncta recover fluorescence after photobleaching, and (C) particles dissipate upon exposure to the organic compound 1,6-Hexanediol. Our system wherein NEMO puncta appeared to be attached to fragmented mitochondria precluded a systematic assessment of standard A. I.e., one NEMO punctum would so rarely encounter another, nor would it be prompted to split, that we could not confirm or rule out the potential for fission and fusion of droplets. This protocol describes our approach to investigating standards B and C.
Image processing to investigate NEMO recruitment and involvement in mitophagy and inflammatory signaling v1
Authors: HARDING OLIVIA
Published: July 2023

Beautiful images are not sufficient to robustly characterize and interrogate a cellular mechanism. In order to show recruitment of NEMO and its relationship to OPTN and other mitophagy factors, we processed hundreds of still and timelapse images and extracted quantifiable data in order to perform statistical analysis comparing different conditions. In many cases, we used software to deconvolve confocal fluorescent images, allowing us to algorithmically surpass the resolution limit. This was especially useful for live cell images that had been collected with low power settings to preserve cell health. We also employed machine learning software to generate binary segmentations and carry out particle analysis on putatively overlapping structures. Finally, in some cases we simply identified fluorescent structures by hand and measured their fluorescent intensities. We approached image analysis in a multitude of creative, effective ways, and importantly we maintained consistency of analysis within experiments in order to present the results with integrity and reproducibility.
The Power of Emotions: The Ethics of Care in the Digital Inclusion Processes of Marginalized Communities
Authors: Pavez Isabel , Correa Teresa , Farías Catalina
Published: July 2023

Digital inclusion research has focused on the conditions, practices, and activities necessary to ensure that all individuals and communities, including the most marginalized populations, can access and use digital technologies. The complexities of Internet appropriation that enable digital inclusion have traditionally been approached from a macro‐level perspective that focuses on access infrastructure policies. Although motivations and social, economic, and cultural capital have been part of the analysis at the individual level, there are still questions about how this process unfolds at the community level. Specifically, little is known about how dynamics and interactions among marginalized groups with weaker online skills and limited Internet access influence technological appropriation. The ethics of care offers complementary insights into this phenomenon, allowing scholars to look at how emotions can trigger actions that lead to the technological involvement of those on the digital periphery. Drawing on 71 in‐depth interviews conducted in person with Internet users in 16 rural and urban communities in Chile, we discuss how care sets the stage for organizing, helping, and teaching others. Our results show that emotions such as empathy, powerlessness, and frustration were vital to giving and receiving forms of care that facilitate digital activities. The findings also suggest that digital assistance is more prevalent in tightly‐knit marginalized communities with more trusting communication patterns.
Türkçe Konuşma Sentezleme Sistemlerinin Geliştirilmesi için Dengeli Bir Veri Kümesi Hazırlama
Authors: CÜCEN Mustafa Sami , OYUCU Saadin , POLAT Hüseyin
Published: July 2023

Konuşma sentezleme (TTS: Text-to-Speech) sistemleri insan-bilgisayar etkileşiminin önemli bir parçasıdır. TTS işleminde bir dizi metne karşılık gelen bir dizi spektrogram tahmin edilmektedir. Elde edilen spektrogram dizisi insanların duyabileceği ses dalga formuna dönüştürülmektedir. TTS sistemlerinin başarısı, geliştirme kaynaklarının yetersizliği nedeni ile farklı diller için aynı düzeyde değildir. Bir TTS sisteminin verimli şekilde geliştirilebilmesi için ulaşılabilir, büyük boyutlu bir konuşma veri kümesine ihtiyaç duyulmaktadır. Türkçe gibi kaynak yetersizliği olan diller için konuşma veri kümelerinin eksikliği, TTS sistemleri geliştirmenin önündeki en büyük engellerden biridir. Büyük boyutlu bir veri kümesi hazırlama oldukça zaman alan, zorlu ve maliyetli bir görevdir. Bu çalışmada, Türkçe TTS sistemlerinin geliştirilmesinde kullanılabilecek bir veri kümesi hazırlanmıştır. Daha önceden hazırlanan metin verisi, bir erkek konuşmacı tarafından İstanbul Türkçesi kullanılarak duygudan bağımsız olarak seslendirilmiştir. Metin verisi 109.826 kelime içermektedir. Seslendirilen konuşma verisi yaklaşık 12 saat 38 dakika 59 saniye uzunluğundadır ve 22.050 Hz. örnekleme frekansında kaydedilmiştir. Türkçe için hazırlanan bu veri kümesi daha önce İngilizce için hazırlanmış ve başarılı sonuçlar elde edilmiş “The LJ Speech Dataset” isimli veri kümesi ile karşılaştırılmış ve gelecekteki çalışmalar için öneriler sunulmuştur. Bu veri kümesi akademik düzeyde Türkçe TTS çalışmalarını teşvik etmek için hazırlanmıştır. Hazırlanan Türkçe veri kümesinin performans durumunu gözlemlemek için GlowTTS modeli bu veri kümesi kullanılarak eğitilmiştir. Eğitilen GlowTTS modeli ile bir Türkçe TTS sistemi geliştirilmiştir. Geliştirilen Türkçe TTS sistemi kullanılarak sentezlenen konuşmalar ile doğal konuşmaların karşılaştırılması sonucu 2,12’lik bir MOS-LQO değeri elde edilmiştir. Elde edilen ilk sonuçlar hazırlanan veri kümesinin Türkçe TTS sistemi geliştirme çalışmalarına etkin bir katkı sağladığını göstermektedir.
Classification and Regression Using Automatic Machine Learning (AutoML) – Open Source Code for Quick Adaptation and Comparison
Authors: TOPSAKAL Oguzhan , AKINCI Tahir Cetin
Published: July 2023

This paper presents a comprehensive exploration of automatic machine learning (AutoML) tools in the context of classification and regression tasks. The focus lies on understanding and illustrating the potential of these tools to accelerate and optimize the process of machine learning, thereby making it more accessible to non-experts. Specifically, we delve into multiple popular open-source AutoML tools and provide illustrative examples of their application. We first discuss the fundamental principles of AutoML, including its key features such as automated data preprocessing, feature engineering, model selection, hyperparameter tuning, and model validation. We subsequently venture into the hands-on application of these tools, demonstrating the implementation of classification and regression tasks using multiple open-source AutoML tools. We provide open-source code samples for two data scenarios for classification and regression, designed to assist readers in quickly adapting AutoML tools for their own projects and in comparing the performance of different tools. We believe that this contribution will aid both practitioners and researchers in harnessing the power of AutoML for efficient and effective machine learning model development.
A Narrative Study
Authors:   , Szilagyi Jillian , Rasmussen Harriette
Published: July 2023

The purpose of this narrative study was to explore primary teachers' perceptions about computer-based reading comprehension assessments to understand their adoption practices and any associated hesitancy around implementing computer-based assessments. As such, this study sought understand how primary teachers explain their experiences, challenges, and benefits of computer-based reading comprehension assessment, as well as the impact of computer-based assessments on how teachers provide feedback to students. Primary teachers' adoption of computer-based reading comprehension assessments may be inconsistent and there is limited understanding about the reasons for this inconsistent adoption. This lack of understanding about how to improve primary teacher computer-based reading assessment adoption could be connected to how morale affects primary teachers' willingness to adapt to 21st century education. Without understanding teachers' perceptions, we will not understand how their perceptions affect computer-based reading comprehension assessment adoption. Three research questions guide this study: (a) What factors influence the adoption of computer-based assessments by primary grade teachers? (b) How do primary teachers' implementation of computer-based reading comprehension assessments explain their perceptions of computer-based assessment in primary grades? and (c) How does computer-based feedback impact the ways in which primary teachers teach and assess reading comprehension? The concept of understanding primary teachers' perspectives on computer-based reading comprehension assessment is part of larger research focused on technology integration within all subjects and grade levels. Keywords: computer-based assessment, technology integration, reading comprehension
Collaboration in Education Services for Children with Special Needs Inclusive School
Authors: Jaya Indra , Maulidina Citra Ashri , Kasirah Irah , Taboer Mohammad Arif , Bahrudin Bahrudin , Yusro Muhammad Najmil
Published: July 2023

Based on the observations and explanations of special guidance teachers in schools, inclusive education providers that the form of collaboration between teachers and stakeholders is still diverse. In general, this study aims to find out and obtain information about the implementation of collaboration between teachers and stakeholders in education services for children with special needs in schools providing inclusive education in Sukabumi. This research is a quantitative research. Data collection techniques are carried out by distributing questionnaires and recording initial data in the form of records that are understood by researchers without reducing the actual data. The results of the study can be concluded that collaboration in several aspects is still lacking such as teacher collaboration with SLB, teacher collaboration with related experts, lack of teacher collaboration with resource centers, teachers are also still lacking collaboration in carrying out learning activities. Meanwhile, there are several aspects that have begun to develop well, including teacher collaboration with parents, as well as teacher collaboration with special guidance teachers in inclusive schools, although not yet dehydrated, maximum results are expected to be a reference in building good collaboration between teachers and related stakeholders in creating effective learning in inclusive education. This study illustrates that inclusive education in its implementation process requires support from teachers and related stakeholders in order to run optimally.
Pengembangan Media Interaktif pada Materi Bangun Ruang Menggunakan Adobe Animate di Kelas V
Authors: Amin Filzah Izzati , Sumarni Sri , Somakim Somakim
Published: July 2023

The use of interactive multimedia has a big impact on education, especially on the mathematics of parts, properties of blocks and cubes. This research aims to produce valid, practical, and effective multimedia. Class V B students of SD Negeri 109 Palembang are the subjects of the field test. The concept of modification of Hannafin and Peck's development pattern is the pattern used in this study, which has 3 stages, namely analyzing needs, outlines, and development and implementation with evaluation and revision at each stage. Tests on materials, designs, and media were carried out by experts and were declared very valid after revising the product. Multimedia is declared practical after a formative evaluation based on the acquisition of a very practical classification. Multimedia learning mathematics is effectively implemented in accordance with the learning outcomes of class VI B students at SD Negeri 109 Palembang. After being reviewed through the results of the percentage of 90% of children successfully achieving the KKM standard and the average value of N-gain is 0.54 with a medium classification. Pemanfaatan multimedia interaktif berpengaruh besar pada pendidikan, terutama pada matematika materi bagian-bagian, sifat-sifat bangun ruang balok dan kubus. Riset ini bertujuan yaitu menghasilkan multimedia yang valid, praktis, dan efektif. Siswa kelasV B SD Negeri 109 Palembang merupakan subjek dari uji lapangan. Konsep modifikasi pola pengembangan Hannafin dan Peck adalah pola yang digunakan pada penelitian ini, yang mempunyai 3 tahapan yakni menganalisis kebutuhan, kerangka bentuk, dan pengembangan beserta penerapan dengan evaluasi dan revisi di setiap tahapnya. Pengujian terhadap materi, desain, dan media dilakukan kepada ahli dan dinyatakan sangat valid setelah melakukan revisi produk. Multimedia dinyatakan praktis setelah dilakukan evaluasi formatif berdasarkan perolehan klasifikasi sangat praktis. Multimedia pembelajaran matematika efektif dilaksanakan sesuai dengan hasil pembelajaran peserta didik kelas VI B di SD Negeri 109 Palembang. Setelah ditinjau melalui hasil persentase 90% anak berhasil tercapai standar KKM serta besaran nilai rerata N-gain adalah 0,54 dengan klasifikasi sedang.
Pengembangan Media Komik Berbasis Etnosains Materi Usaha dan Pelestarian Lingkungan Kelas V Sekolah Dasar
Authors: Fauziah Hasna , Winahyu Sri Estu , Untari Esti
Published: July 2023

The research and development carried out aims to create comic learning media based on ethnoscience that is valid based on media and material experts, practical based on teachers, and creates interest for students. The research applies ADDIE modeling which consists of 5 stages: 1) analysis, 2) design, 3) development, 4) implementation, 5) evaluation. Instruments in research use questionnaires, then analyze them using qualitative and quantitative data analysis. The results of the development are in the form of ethnoscience-based comic learning media products with science content, especially business materials and environmental conservation. This media is in the form of printed books. The material is presented through a story with interesting color images. The average score of the product evaluated by media experts is 96 percent, material experts 100 percent, and teachers as end users 92.5 percent. The validity and suitability of the product for use, as indicated by the validation findings, does not include any changes to the product. Small-scale testing results in a 90 percent attractiveness score, while large-scale testing results in a 96 percent score. Based on the results of that percentage, it concludes that ethnoscience-based comic learning media is valid based on media and material experts, practical based on teachers as users, and creates interest for fifth grade elementary school students.Penelitian dan pengembangan yang dilaksanakan bertujuan untuk menciptakan media pembelajaran komik berbasiskan etnosains yang valid berdasarkan ahli media dan materi, praktis berdasarkan guru, dan menciptakan ketertarikan untuk siswa. Riset menerapkan pemodelan ADDIE yang terdiri dari 5 tahap: 1) analysis, 2) design, 3) development, 4) implementation, 5) evaluation. Instrumen dalam riset mempergunakan angket, kemudian dianalisisnya mempergunakan menganalisis data kualitatif maupun kuantitatif. Hasil pengembangan berupa produk media pembelajaran komik berbasis etnosains dengan muatan IPA khususnya materi usaha dan pelestarian lingkungan. Media ini berupa buku cetak. Materi disajikan melalui cerita dengan gambar berwarna yang menarik. Skor rerata produk yang dievaluasi oleh ahli media adalah 96%, ahli materi 100%, dan guru sebagai pengguna akhir 92,5%. Validitas dan kesesuaian produk untuk digunakan, seperti yang ditunjukkan oleh temuan validasi, tidak termasuk perubahan apa pun pada produk. Pengujian skala kecil menghasilkan skor daya tarik 90%, sedangkan pengujian skala besar menghasilkan skor 96%. Didasarkan atas hasil persentase itu, menyimpulkan yakni media pembelajaran komik berbasis etnosains valid berdasarkan ahli media dan materi, praktis berdasarkan guru sebagai pengguna, dan menciptakan ketertarikan untuk siswa kelas V SD.
Ohio Journal of Public Health Vol. 5, Issue 2 (July 2023): Full Issue
Authors: Ohio Public Health Association OPHA
Published: July 2023

No abstract available.
System dynamics analysis of mortality post allogeneic hematopoietic stem cell transplant
Authors:   Al muthanna medical college, Yousif Nasser , Alamran Fadhil
Published: July 2023

Allogeneic hematopoietic stem cell transplantation is a well-proven treatment for hematologic malignancies and non-malignancies, but it has a high risk of disease recurrence and severe transplant-related morbidity and death. The mortality and long-term survival of post-allogeneic hematopoietic stem cell transplant patients are improving due to improvements in condition procedures, methods, novel medicines, and supportive care practices. Allogeneic hematopoietic stem cell transplant (allo-HCT) findings, nonetheless, still present a chance for recovery. The results of this investigation updated previous research on risk factors for death following allogeneic HCT. We performed a systematic review and meta-analysis to assess mortality post allo-HCT through a comprehensive literature search using PUBMED/MEDLINE, CINAHL, Web of Science, and EMBASE up to April 30, 2023 and extracted clinical outcome data relating to benefits followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The search identified 551 studies. Only 12 studies (n = 450 patients) met our inclusion criteria. OS rates were the subject of the meta-analysis. The following were the outcomes of heterogeneity tests: According to Chi2=9.14, df=6, P=0.17, and I2=34 percent, the study's data did not appear to be heterogeneous. The OS rate did not differ significantly (P>0.05) using the fixed-effect model analysis. In conclusion, the HSCT must offer the best overall survival, quality of life, and cost outcomes compared to any other treatment strategy. More studies will need a lot of data, and careful data analysis will help get clear data on HSCT outcomes.
Analysis of the influence of air quality on the performance of the Boeing 737-800 evaluated during takeoff at El Dorado Airport
Authors: Lugo Juan David , Reina Santiago Marcelo , Martínez Nicolás , Salazar Ruben , Vega Jesus , Longas Luis
Published: July 2023

This paper analyzes how the Bogotá’s air quality and pollutant levels affects the Boeing 737-800 take-off performance in terms of the available runway distances and maximum \newtext{take-off} weight, which are two of the most restrictive factors in airlines' operation. The airport runway's physical characteristics, geographical position, surroundings, and atmospheric conditions affect the maximum aircraft \newtext{take-off} weight. This study examines: (a) the influence of pollutants in Bogotá’s air quality and its subsequent effects in air density; (b) the maximum available polluting agents and relative humidity measures in this city; (c) the maximum take-off weight of the aircraft with and without air degradation due to atmospheric considerations. Software called “Aircraft Take-Off Software” has been developed to determine the B737-800 most limiting take-off weight of in specific geographical and atmospheric conditions. This study reflects the effect of high populated cities pollution on the aircraft operational performance which analysis has demonstrated that the presence of high carbon dioxide concentrations in the air increase the B737-800 payload capacity taking off from Bogotá but in the other hand, relative humidity variation decreases this capacity drastically, showing that considering Bogotá’s relative humidity and pollutant levels, the most restrictive weight situation for the take-off phase is the “Climb Limit Take-Off Weight”; however, as it is an aerodynamic study of the pollutants influence in engine combustion the structural integrity was not considered and for further investigation it should be considered to determine more accurately the most restrictive take-off weight.
Design of Wind Power Generator for Tambak Houses
Authors: Marhatang Marhatang , Nawir Herman , Djalal Muhammad Ruswandi , Maudini Maudini , Syarifuddin Muh Amar
Published: July 2023

Wind Power Generation (WPG) requires specific wind conditions to generate electrical energy. Indonesia's wind potential enables the development of small-scale power plants. Innovations in windmill technology need to be developed to ensure maximum results in low wind speed conditions. This research proposes the design and implementation of WPG using a vertical axis to provide lighting for pond houses. The goal is to benefit pond workers in coastal areas that lack electricity from the National Electric Company. The manufacturing stages include design and testing. Based on the design results, the dimensions of the propeller area are 0.393m, the frame height is 1.5m, and the wind turbine height is 0.75m. The performance test of the WPG yielded the highest turbine power value at 15.30 WITA, with a turbine power output of 25.38 Watts.
Public Relations Strategies in Disseminating Information through Instagram Social Media in DIY Government
Authors: Rahmata Muhammad Ibnu
Published: July 2023

This study aims to identify the strategy of the Public Relations Department of the Regional Government of Yogyakarta Special Region in disseminating information through Instagram and to identify the inhibiting and supporting factors in its management. The subjects of this study were the Head of the Public Relations Department of the Regional Government of Yogyakarta Special Region, the administrator of the Regional Government of Yogyakarta Special Region’s social media, and one of its followers on Instagram. The study used a qualitative descriptive approach whose data were compiled through observation, interviews, and documentation. The result showed that in the process of disseminating information through Instagram, the Public Relations Department of the Regional Government of Yogyakarta Special Region applied the following phases: 1) Fact-finding, 2) planning, 3) communication, and 4) evaluation. To manage the Public Relations Department, it applied strategic planning to realize the goal set by the Public Relations Department of the Regional Government of Yogyakarta Special Region itself.
Tasamuh Religion: Study on Simpul Iman Community (SIM-C)
Authors: Syayekti Ela Indah Dwi , Nurrohmah Shinta , Alghozali Ahmad Mirshad
Published: July 2023

Simpul Iman Community is a forum for interfaith theological dialogue between students of Sanata Dharma University, Duta Wacana Christian University, and Sunan Kalijaga State Islamic University, Yogyakarta. This organization was born as a form of maintaining tolerance and the teachings of compassion from every religion. The purpose of this research is to find out how the forms of interreligious communication that occur in SIM C. This study uses a qualitative approach with an observational method that observes how members of the SIM C organization engage in dialogue. The results of this study indicate that all activities are carried out with the awareness that all human beings can live together based on tolerance and compassion. The content and method of dialogue are not only about theological debates but also about how implementing the teachings and values of divinity in each religion affects life in society. The way SIM C dialogue members do not offend one another. They dialogue tolerantly and do not touch the sensitive side of each religion. It is hoped that this research can be a reflection to create spaces for dialogue between faiths to create harmony in the nation's life.
Trends of smokeless tobacco in India- Narrative review
Authors: Bhateja Sumit , Tripathi Riya , Jasrotia Ritika , Arora Geetika , Kumar Ashish
Published: July 2023

South Asia, primarily India, is the major producer and exporter of various forms of tobacco products worldwide. All forms of tobacco (smoke and smokeless/chewable/inhaled) such as cigarettes, pipes, cigars, beedis, paan and snuff have been implicated in the development of oral cancer. Almost 13% of the population of India chews tobacco in the form of pan or gutkha. People in India consume various forms of tobacco such as khaini, mishri, zarda, gutkha, mawa and naas. Areca nut chewing is also widely practised in India. Males have been found more likely to develop oral or esophageal cancer because of tobacco consumption. Children, teenagers and pregnant women are also found using products for pleasure, stress relieving, in social situations etc. Epidemiological studies also suggest tobacco consumption is more prevalent in lower socioeconomic strata. Oral cancer also called squamous cell carcinoma, oral submucous fibrosis (OSMF), leukoplakia, erosive lichen planus, asthma, chronic obstructive pulmonary disease (COPD) and hypertension are a few major manifestations of tobacco consumption. Smokeless tobacco users studies show mortality of 1.2–1.96 (men) and 1.3 (women). Educational intervention, mass media intervention in the form of television ads, public posters, newspaper articles, folk dramas and the most recent cessation camps have been implied to spread awareness about the misbeliefs of consuming tobacco and demonstrating health hazards associated with it.
Comparison of hemodynamic response of small dose ketamine versus midazolam as co- induction agent to propofol: a randomized double blind interventional study
Authors: Chauhan Sunil , Kothari Sandeep , Chaudhary Nitish , Mantan Kiwi
Published: July 2023

The Anaesthesiology Department at Sawai Man Singh Medical College carried out this study. For this, 60 ASA grade I and II patients undergoing planned general surgery were randomly assigned into two groups of 30 each, with Group KP (n=30) receiving injections of ketamine at 0.3 mg/kg and Group MP receiving injections of midozolam at 0.03 mg/kg and Propofol I.V. The main goal of the study was to find the best induction by analysing changes in hemodynamic indicators from baseline to various time points after induction. On the basis of the necessary induction dose and hemodynamic characteristics, the groups were contrasted. The strategy used was to present the categorical data as percentages and compare them between groups using the Chi square test. The mean and standard deviation of the quantitative data were displayed, and students' t-tests were used to compare them. According to the study described above, group MP saw a greater fluctuation in heart rate than did group KP, whose heart rate remained more constant during the anaesthetic time. Group MP's blood pressure dropped more quickly after induction compared to group KP. The ketamine group's blood pressure remained the most stable out of all the groups. Apnea, pain upon injection, and uncontrollable movements were absent in the KP group. Of all the groups, the ketamine-propofol group required the least induction dose. As a result, we came to the conclusion that pretreatment with ketamine at a dose of 0.3 mg/kg results in better hemodynamic stability and requires less propofol for induction than midazolam does. The ketamine-propofol group is therefore the best of the two groups, making it the optimum induction agent
Comparing intravenous clonidine and nalbuphine for attenuating hemodynamic response to laryngoscopy and improving perioperative outcomes in laparoscopic surgeries
Authors: Mantan Kiwi , Chahar Neha , Kothari Sandeep , Rakesh Dr , Joshi Gaurav
Published: July 2023

The Department of Anaesthesia at SPMC Bikaner approved the trial and it was carried out during laparoscopic surgery OT with proper informed written permission. The study was a double-blind, randomised, prospective interventional trial. The study comprised 60 (ASA) Classes I and II patients between the ages of 18 and 60 who were scheduled for elective laparoscopic cholecystectomy. Using a computer-generated random number sequence, patients were divided into two groups of 30 each: Group A received 1.5 mg/kg of clonidine, whereas Group B received.2 mg/kg of nalbuphine in a 50 ml NS solution. Prior to administering the study drug, five minutes after premedication, hemodynamic parameters were recorded. Double-blind administration of the study medication occurred more than 10 minutes before anaesthesia onset. Hemodynamic parameters were recorded following the administration of the study medication, 1 and 5 minutes after intubation, prior to pneumoperitoneum, 5 minutes, 10 minutes, 20 minutes, 30 minutes, and 40 minutes after pneumoperitoneum, and finally following extubation. following 1 minute and 5 minutes after intubation (and following pneumoperitoneum at 5 minutes, 10 minutes, 20 minutes, and post extubation), it was discovered that there was a substantial difference in heart rate, SBP, DBP, and MAP between Group A and Group B. In our investigation, hemodynamics related to heart rate were improved with clonidine. Based on the results of our study and other earlier research conducted by different authors, we came to the conclusion that both clonidine and nalbuphine, when administered 5 minutes prior to intubation in patients undergoing laparoscopic surgery, attenuated the hemodynamic response to intubation and pneumoperitoneum during the surgery. The difference in heart rate, systolic and diastolic blood pressure, and mean arterial pressure is much less with clonidine than with nalbuphine, which leads us to the conclusion that clonidine produced greater hemodynamic response than nalbuphine.
Functional assessment of all polyethylene tibial monoblock component in total knee arthroplasty
Authors: Nadaf Moinuddin , Patil Sharan S , Huchchannavar Raghavendra R
Published: July 2023

Background: In a developing country like India the cost effectiveness of all polyethylene tibial components is a major boon, without compromising the functional outcome. In this study we have attempted to evaluate the functional outcome of all polyethylene tibial monoblock component in total knee arthroplasty. Methodology: The study was carried out on 86 patients who are operated for total knee arthroplasty with all polyethylene tibial monoblock component. Demographic, surgical and follow up data was collected from case sheets of patients and copied in Performa. The patients were called for five years follow up and examined in the outpatient department. Results: The mean age of study population was 62.8 years (range 50 – 72 years) with mean BMI of 27.6 kg/m2. Statistically significant improvement was seen in the range of movements in all the age groups. Both male and female patients had insignificant difference in knee scoring. Assessment of clinical functional abilities of knee scoring have observed to be higher in patients with lower BMI. Conclusion: Significant improvement in range of motion as well as knee score in all age range, emphasizes the fact that total knee arthroplasty with all polyethylene design in osteoarthritis is an excellent surgery to restore near normal life style.
A comparative study of intravenous fentanyl and ultrasound-guided femoral nerve block for positioning during spinal anaesthesia in femur fracture surgeries
Authors: Rajbala Dr , Beniwal Sonali , Khandelwal Mamta , Thomas T Mirthun
Published: July 2023

Objective: To assist in the administration of spinal anesthesia for patients undergoing femur fracture procedures, we conducted comparison research to compare the analgesic efficiency of intravenous fentanyl against ultrasound-guided femoral nerve block (FNB). Material and Methods: A group of 112 patients ranging in age from 18 to 70 years old who had ASA Physical Status I and II and were having femur fracture procedures under spinal anaesthesia participated in the randomised, prospective, interventional trial. These individuals were divided into two groups through a random assignment process. Group FENT (n = 56) received Intravenous fentanyl 1 microgram/kilogram (µg/kg) and five minutes before positioning for spinal anaesthetic, group FNB (n = 56) received ultrasound-guided FNB with 20 millilitres (ml), 1.5% lignocaine and adrenaline (1:200,000). Results: Comparison of pain scores during positioning using the Visual Analog Scale (VAS) revealed that Group FENT had a score of 1.95 ± 0.585, whereas Group FNB had a score of 0.61 ± 0.562 (p-value 0.001). The FNB group demonstrated superior patient positioning quality. Patient satisfaction was similar in both groups, and no significant side effects were observed. Conclusion: FNB offers enhanced analgesia, improved patient positioning, higher patient satisfaction, reduced reliance on additional analgesia, and fewer side effects compared to intravenous fentanyl for spinal anesthesia.
Astudy on prognostic significance of neutrophil-lymphocyte ratio in patients with stemi
Authors: M Nallathambi , G Anurekha , C Paranthakan
Published: July 2023

Atherosclerosis, the clinically manifested form of cardiovascular disease (CVD), mainly accounts for most deaths worldwide. Inflammatory disorders that elevate CVD risk have been associated with circulating inflammatory markers that encompass neutrophil-lymphocyte ratio (NLR), which could be employed as an economical prognostic tool for the diagnosis of the same.

Hence, this study focused on assessing the extrapolative implication of NLR among ST-Elevation Myocardial Infarction (STEMI) patients.

The observational study included 55 STEMI patients (Mean age – 52.08 years) at Thanjavur medical college (December 2015 to February 2016). The patients were delineated into two groups based on NLR values (high >3.0 and low <3.0).

Among the 55 patients, the post-MI complication was observed in 44 subjects, among which 10% of them expressed a high NLR value. A notable proportion of patients displaying arrhythmia and LV dysfunction had higher NLR values.

Henceforth, the study reveals the independent and vital prognostic association between NLR and atherosclerosis that could be designated as a reliable marker in the early diagnosis of the disease as well post MI complications.
Is fixed dose combination of rosuvastatin with fenofibrate more effective than high dose Rosuvastatin inpatients with stable coronary artery disease with mixed dyslipidemia? A study
Authors: Bharti Rupendra Kumar , Kosawara Pratima , Negi P S , Kaundal P K
Published: July 2023

: We aimed to compare lipid lowering efficacy and safety of fixed dose combination (FDC) of rosuvastatin and fenofibrate with high dose rosuvastatin (HDR) in patients of stable coronary artery disease (CAD) with mixed dyslipidemia.

: 165 patients with stable CAD with mixed dyslipidaemia were randomly assigned to HDR group, 40mg per day (n=79) and FDC group; fenofibrate with rosuvastatin, 145 mg and 20 mg per day respectively (n=88). The lipid profile was measured at baseline and at 12 weeks. The safety profile was measured by recording self-reported adverse reactions during follow up visits and by measuring serum levels of transaminases, creatinine phosphokinase (CPK) at 4 weeks. The lipid lowering efficacy was compared by estimating differences in percentage mean change from baseline values of the lipid fractions and percentage of patients achieving target goals between study groups using unpaired t test and Xtest respectively.

: The FDC achieved greater reduction compared to HDR in LDL-C, -11.0% 95% C.I. (-17.7% to -4.3%) p<0.001, NHDL-C levels, -10.1% (-16.0% to -4.2%) p<0.001, triglyceride, -18.4% (-32.0% to -4.7%) p<0.0001. The increase in HDL-C was significantly higher in FDC arm, 14.9% (8.3% to 21.4%) p<0.001.The percentage of patients achieving LDL-C and Non HDL-C target goals were higher in FDC arm but difference was statistically not significant. The FDC was tolerated well than HDR regimen.

: The combination of moderate dose rosuvastatin and fenofibrate is more effective in reducing atherogenic lipid fractions and increasing the HDL-C level compared to high dose rosuvastatin and had better safety profile.
Clinical outcome of in-hospital cardiac arrest: An observational study in Indian setting
Authors: Kabi Ankita , Patel Sanket M , Verma Aakash , Tamilarasu Kumaresh Pillur , Asokan Reshma , Alok
Published: July 2023

The studies on In-Hospital Cardiac Arrest are limited by the fact that most of them are carried out for patient admitted in ICU. Particularly for ward patients, there lies a big void in literature and hence this research study was undertaken in order to study the clinical outcome of in-hospital cardiac arrest for the patients admitted in ward.

A hospital based observational study among 119 patients was undertaken to evaluate the clinical outcome of In-Hospital cardiac arrest in patients presented to Deenanath Mangeshkar Hospital & Research Centre, Pune over a period of 2 years.

Male to female ratio of cardiac arrest patients was 1.8:1 with higher incidence in age group 61-70 years (28.6%). 44 patients that were admitted in ward in first place, 25% (11 patients) survived 24 hours post resuscitation and a total of 4 patients were discharged from the hospital. Rest 75 patients required ICU admission initially and were later sent to ward where they sustained a cardiac arrest. 24 patients (32%) from this group survived 24 hours post cardiopulmonary resuscitation and 12 patients (16%) were discharged from the hospital later.Out of 119 patients, 55.5% patients had revival immediately post resuscitation and 44.5% patients died post resuscitation.

Patient with shockable initial rhythm on monitor had better outcomes than non-shockable rhythm so early defibrillation is advised in shockable rhythm. Of all the patients who had a cardiac arrest, those with cardiac causes and electrolytes disturbance as a preceding cause of arrest had a better outcome.
Water inflow sealing method for casing annulus in water well construction
Authors: Romanov A.A
Published: July 2023

The results of practical use of bentonite cords for annulus sealing in water wells are given. The studies have shown that using bentonite cords such as Ikopal or Aquastop tightly seals the casing shoe against water of upper quaternary aquifers. When the bentonite cord swells up, a water-tight plug is created, which prevents near-surface water to penetrate the annulus.
Forms of Child Sexual Abuse in the European Space
Authors: Khmelnitskaya T.V , Nesterenko S.E
Published: July 2023

This article examines the forms of child sexual abuse in European countries. What criminal liability exists for these crimes? Which country has the most effective programs to protect children from sexual abuse?
Современные технологии в сельском хозяйстве
Authors: Дедюлин В.Л
Published: July 2023

Статья освещает одну из актуальных схем развития сельского хозяйства - внедрение современных технологий, точного земледелия (в том числе беспилотной) с последующей автоматизацией, что позволит значительно повысить эффективность сельского хозяйства, увеличить его товарооборот, путѐм снижения затрат.
Использование сверточной нейронной сети для системы автоматической диагностики и контроля состояния устройства для очистки колонны насосно-компрессорных труб
Authors: Иванов И.В.
Published: July 2023

В данной статье исследуется использование сверточной нейронной сети (СНС/CNN) для автоматической диагностики и контроля состояния устройства, которое очищает колонну насосно-компрессорных труб. СНС обрабатывает данные от датчиков, установленных на устройстве, и выдает прогноз о его состоянии. Этот подход позволяет операторам быстро реагировать на проблемы и предотвращать аварии. Эксперименты подтвердили эффективность СНС в этой задаче
Причины и факторы наезда подвижного состава
Authors: Иващенко Г.И
Published: July 2023

Наезд подвижного состава – это серьезная проблема, которая может привести к различным последствиям, включая травмы, смерть и материальные потери. Факторы, которые могут привести к наезду подвижного состава, могут быть различными и включать в себя как человеческие, так и технические проблемы
Влияние физической активности на примере скандинавской ходьбы на вариабельность сердечного ритмa
Authors: Имамов Р.Э , Тимофеева А.М. , Тимофеева Е.Б
Published: July 2023

Вариабельность сердечного ритма (ВСР)— физиологическое явление, проявляющееся в изменении интервала между началами двух соседних сердечных циклов. Оценивается по изменениям интервала времени между соседними сердечными сокращениями (сердцебиениями). Изучение вариабельности сердечного ритма (ВСР) важно, поскольку оно дает ценную информацию о здоровье и функционировании вегетативной нервной системы, которая контролирует многие жизненно важные функции организма, такие как частота сердечных сокращений, артериальное давление и пищеварение. ВСР является мерой изменения времени между каждым ударом сердца и отражает способность вегетативной нервной системы реагировать на изменения в окружающей среде. Исследования показали, что ВСР связана с различными последствиями для здоровья, включая сердечно-сосудистые заболевания, диабет, депрессию и тревогу. Низкая ВСР была связана с повышенным риском этих состояний, в то время как высокая ВСР была связана с лучшими результатами для здоровья. Изучение ВСР также может быть полезно для оценки влияния различных вмешательств, таких как физические упражнения, методы управления стрессом и прием лекарств, на вегетативную нервную систему. Отслеживая ВСР, медицинские работники могут получить представление об эффективности этих вмешательств и соответствующим образом адаптировать планы лечения.
Инженерно-экологическое состояние анализируемого участка автомобильной дороги
Authors: Дормидонтова Т.В , Шкотина А.В
Published: July 2023

В статье рассматривается уровень загрязнения атмосферного воздуха, радиационноэкологические исследования, химические загрязнения, биологическое загрязнение почв, анализ уровня шума участка автомобильной дороги. Представлены мероприятия по ликвидация последствий негативных воздействий на экологическую ситуацию автомобильной дороги. Приведены цели экологического мониторинга, контроль экологического состояния территории.
Исследование применения шумозащитных экранов
Authors: Карпова Е.С , Павлова Л.В
Published: July 2023

В статье рассматриваются вопросы исследования проблем дорожного шума, с которыми сталкиваются многие страны мира. Шум оказывает отрицательное влияние на здоровье людей и животных, а также на окружающую среду. Дорожные шумозащитные экраны - это один из возможных способов борьбы с этой проблемой. Выбор правильных материалов и конструкции является важным для создания эффективных шумозащитных экранов. статьи.
Двухфазные термосифоны: технология эффективного и рационального использования энергии
Authors: Маслов И.Н , Фахразов А.С.
Published: July 2023

В этой статье предложена технология двухфазных термосифонов как реальная альтернатива целенаправленному решению проблемы эффективного использования энергии в различных производственных секторах страны. Описан способ работы данной технологии, материал изготовления и возможности применения в многих областях
Дорожные ограждения, повышающие безопасность движения на автомобильных дорогах
Authors: Говердовская Л.Г , Костырь Д.В
Published: July 2023

Сегодня тысячи человек расстаются с жизнью на автомобильных дорогах в дорожнотранспортных происшествиях. Дорожные ограждения позволяют увеличить безопасность дорожного движения на автомобильных дорогах, но возможность получения травм пассажирами при столкновении с ограждением велика. Именно поэтому необходимо создание и применение такого дорожного барьерного ограждения, которое будет обладать не только большой удерживающей способностью, но и определенной гибкостью для более «мягкого» удара и сохранения человеческих жизней в транспортном средстве.
Концепция построения автоматического регулирования температуры судовых дизелей
Authors: Тимофеев В.Н , Тихонов Н.Ф
Published: July 2023

Проанализированы системы автоматического регулирования температуры, отражены наиболее перспективные и экономически выгодные из них. Рассмотрены основные этапы по повышению эффективности и технико-экономических показателей судовых энергетических установок (СЭУ) за счѐт применения термоэлектрических регуляторов, комплексной автоматизации систем, повышению их коэффициента полезного действия. Произведен анализ основных задач и перспектив развития эксплуатационных достоинств современных систем регулирования температур.
Роль искусственного интеллекта в будущем развитии военных систем связи в России
Authors: Данилюк А.И. , Чеботарь И.Т , Ренсков Д.А
Published: July 2023

Искусственный интеллект (ИИ) становится все более важным во многих областях жизни, и военные системы связи не являются исключением. В данной статье рассматривается роль ИИ в будущем развитии военных систем связи в России. Проанализированы потенциальные преимущества, вызовы и перспективы применения ИИ в области военной связи, а также обсуждаются возможные направления исследований и разработок в этой области.