bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of Endometrial Scratch in UnExplained infertility (RESCUE); A Randomized Clinical Trial
Authors: elkhateeb reham , Bahaa Haitham , Gamal Alaa , Ibrahim Mahmoud , Toni Nisreen , Elsherif Ameer , Mahmoud mohmmed , Mahran Ahmad
Published: November 2021

Background Endometrial natural killer (NK) is thought to play a role in implantation and maintenance of a healthy pregnancy. However, their immunological role in unexplained infertility is yet unknown. The aim of the current study was to investigate the role of endometrial injury in treatment of unexplained infertility and to have more insight on the potential underlying mechanisms of its action methodology randomized controlled trial (RCT) done at Minia university hospital, diagnostic laparoscopy was done for both study and control group, study group had gentle scratch and specimens were sent for histopathological examination while control group had Laparoscopy only .Patients in both groups were followed up at the outpatient clinic for 3 months to assess if pregnancy achieved or not. Patients in the study group who had not achieved pregnancy had a repeated scratch using a pipelle sampler which was also sent for histopathology. Patients were counselled for intrauterine insemination (IUI) with ovulation induction while patient in control group had been counselled for IUI and ovulation induction only. Patients in both groups were followed up for further 3 months to assess patients who achieved pregnancy either naturally or after IUI . Results Baseline characteristics were comparable in both groups. Clinical pregnancy rate (CPR) was significantly higher in scratch group compared with the control group (22%; vs. 7.4%, P = 0.001) in the first three months of follow up. After second scratch and IUI cycles cumulative pregnancy rate was significantly higher in the scratch group compared with the control group (36.7% , vs. 16.2%,, P = 0.001). The mean time achieve pregnancy was found to be significantly shorter in the scratch group as compared to the control group (102 days vs.49.5 days, P = 0.01). Conclusion: Endometrial natural killer cells might play a crucial role in endometrial receptivity and therefore embryo implantation. Endometrial scratch could promote the recruitment of endometrial NK cells and give a more favourable results as regard clinical pregnancy in patients with unexplained infertility. Registration number PACTR201604001405465
Food Insecurity and Associated Factors Among Adult HIV Patients on Anti-Retroviral Therapy in Dessie Referral Hospital, South Wollo Zone, North Central Ethiopia
Authors: Demise Amanuel , Demena Melake , Hawulte Behailu , Mengistu Abrham
Published: November 2021

Background

Food insecurity has a paramount negative impact on the overall nutritional and health status of people living with the human immune deficiency virus, hence leading to opportunistic infections, rapid disease progression, hospitalizations, poor treatment outcomes, and mortality. Both are intertwined and worsen one another in a vicious cycle through a mixture of nutritional, mental health, and behavioral pathways that heighten vulnerability to, and worsen the severity of, each condition. Nevertheless, little is known about the magnitude of food insecurity and associated factors among adults on antiretroviral therapy in sub-Saharan Africa countries including the current study area.
Objectives

To assess the magnitude of food insecurity and associated factors among Adults on Antiretroviral Treatment in Dessie referral hospital South Wollo Zone, Northcentral Ethiopia
Methods and Materials:

An institution-based cross-sectional study was conducted among 420 randomly selected adults living with HIV/AIDS receiving ART in Dessie referral hospital. Data was entered into Epi-data version 3.1 and exported to STATA version 16.0 for cleaning and analysis. Bivariate and multivariate binary logistic regression analysis was carried out to identify factors associated with the outcome variable. Odds ratio along with 95% confidence interval was estimated to measure the strength of the association and the level of statistical significance was declared at a p-value less than 0.05
Results

The magnitude of food insecurity among adults on ART was 62.4% (95% CI: 57.6, 66.8]. CD4 count <350 [AOR=3.51, 95% CI: 1.88, 6.52], average monthly household income ≤ 40 USD [AOR= 2.34, 95% CI: 1.42, 3.84], WHO clinical stage III&IV [AOR=2.85, 95% CI: 1.61, 5.04], not getting any support [AOR= 3.04, 95% CI: 1.45, 6.38] were factors significantly associated with food insecurity.
Conclusion

Around two-thirds of the adult people living with HIV on ART at Dessie referral Hospital were experiencing food insecurity. Thus, social protection interventions targeting patients with CD4 <350, income less than 40 USD/month, WHO clinical stage III &IV, and those patients with no support are crucial interventions for food security.
Proliferative Effect of Aqueous Extract of Sea Cucumber (Holothuria Parva) Body Wall on Human Umbilical Cord Mesenchymal Stromal/stem Cells
Authors: Rasekh Poorya , Kameli Ali , Khoradmehr Arezoo , Baghban Neda , Mohebbi Gholamhossein , Barmak Alireza , Nabipour Iraj , Azari Hossein , Heidari Yaser , Daneshi Adel , Bargahi Afshar , Khodabandeh Zahra , Zare Shahrokh , Shirazi Reza , Almasi-turk Sahar , Tamadon Amin
Published: November 2021

Background: The sea cucumber potentials for stem cell proliferation induction and their mechanisms of bioactive compounds in its extract have been studied. Human umbilical cord mesenchymal stromal/stem cells (hUC-MSCs) were exposed to aqueous extract of Holothuria parva body wall. Methods: Using GC-MS analysis on aqueous extract of H. parva, proliferative molecules were detected. The extract concentrations of 5, 10, 20, 40, and 80 µg/mL and 10 and 20 ng/mL of human epidermal growth factor (EGF) as positive controls were used. MTT proliferation, cell count, viability, and cell cycle assays were performed. Using Western blot analysis, effects of aqueous extract of H. parva and EGF on cell proliferation markers were detected. Computational modeling done to detect effective proliferative compounds in aqueous extract of H. parva. Results: MTT assay showed that the 10, 20, and 40 µg/mL aqueous extract of H. parva had proliferative effects on hUC-MSCs. Count of the cells treated with the 20 µg/mL of the extract was increased faster and higher than the control group (P<0.05). This concentration of extract did not have significant effects on hUC-MSCs viability. The cell cycle assay of hUC-MSCs showed that percent of cells in the G2 stage of the extract was biologically higher than the control group (P>0.05). Expression of the cyclin D1, cyclin D3, cyclin E, HIF-1α, and TERT were increased comparing with the control group. Moreover, expression of the p21 and PCNA decreased after treating hUC-MSCs with the extract. However, the CDC-2/cdk-1 and ERK1/2 had almost the same expression as the control group. The expression of the cdk-4 and cdk-6 was decreased after treatment with the extract. Between the detected compounds, 1-methyl-4-(1-methylethenyl)-benzene showed better affinity to cdk-4 and p21 than tetradecanoic acid. Conclusions: The H. parva aqueous extract showed proliferative potential on the hUC-MSCs.
Discovery of Genes Positively Modulating Treatment Effect Using Potential Outcome Framework and Bayesian Update
Authors: Lee Young Keun , Kim Jisoo , Seo Sung Wook
Published: November 2021

BackgroundThe recent explosion of cancer genomics provides extensive information about mutations and gene expression changes in cancer. However, most of the identified gene mutations are not clinically utilized. It remains uncertain whether the presence of a certain genetic alteration will affect treatment response. Conventional statistics have limitations for causal inferences and are hard to gain sufficient power in genomic datasets. Here, we developed and evaluated an algorithm for searching the causal genes that maximize the effect of the treatment.MethodsThe algorithm was developed based on the potential outcome framework and Bayesian posterior update. The precision of the algorithm was validated using a simulation dataset. The algorithm was implemented to a cBioPortal dataset. The genes discovered by the algorithm were externally validated within CancerSCAN screening data from Samsung Medical Center.ResultsSimulation data analysis showed that the C-search algorithm was able to identify nine causal genes out of ten. The C-search algorithm shows the discovery rate rapidly increasing until the 1500 number of data. Meanwhile, the log-rank test shows a slower increase in performance. The C-search algorithm was able to suggest nine causal genes from the cBioPortal Metabric dataset. Treating the patients with the causal genes are associated with better survival outcome in both the cBioPortal dataset and the CancerSCAN dataset which is used for external validation.ConclusionsOur C-search algorithm demonstrated better performance to identify causal effects of the genes than multiple rog-rank test analysis especially within a limited number of data. The result suggests that the C-search can discover the causal genes from various genetic datasets, where the number of samples is limited compared to the number of variables.
Application of Hip Amputation Under Non-Ischemic Condition in the Treatment of Sarcomar
Authors: Zhou Rang , Sun Yang , Pan Zhihao , Shi Qingyu
Published: November 2021

Background: Amputation is an effective treatment for sarcoma of the hip. Traditional amputation is performed by separating the major arteries and veins of the limb and blocking the blood supply to the limb, which may have adverse effects on the patient.Methods: Ten patients with pathologically clearly diagnosed bone and soft tissue sarcoma undergoing hip amputation in a non-ischemic state between April 2019 and April 2021 at the Affiliated Cancer Hospital of Harbin Medical University were selected. Factors related to operative time, intraoperative bleeding, phantom limb pain, incisional infection, and flap necrosis were statistically evaluated at 7 days postoperatively and 3 months postoperatively.Results: Ten patients were followed up for 3-24 months with a mean of 13 months. No bleeding secondary surgical complications occurred in all patients, and none had postoperative infections. Postoperative flap necrosis occurred in one case in the modified hemipelvic amputation patients, and no flap necrosis occurred in the hip disarticulation patients. In the non-ischemic hemipelvic amputation group, the operation time was 4.5-5.5h, with a mean of 5h, and the operation bleeding volume was 300-1000ml, with a mean of 700ml; in the hip disarticulation group, the operation time was 2.5-3.5h, with a mean of 2.9h, and the operation bleeding volume was 300-450ml, with a mean of 357ml; phantom limb pain in the non-ischemic amputation group 7 days after operation, the VAS pain score was 4 -6 points, mean 4.5 points; VAS pain score 3-4 points, mean 3.4 points at 3 months postoperatively.Conclusions: In hip amputation for bone and soft tissue sarcoma, the main arterial and venous approaches to the limb are ligated near the end of surgery, leaving the amputated limb in a non-ischemic state at the distal end of the amputation, without pathological reactions due to limb ischemia. Non-ischemic hip amputation is more suitable for the surgical treatment of locally advanced lesions of sarcoma.Trial registration: retrospectively registered
Comprehensive Analysis of the Immune Microenvironment Reveals that CD52 is a Marker for Breast Cancer Treatment with Immune Checkpoint Inhibitors
Authors: Wang Qiang , Liu Xuxu , Wang Pengfei , Luo Dankun , Gao Wenqi , Sun Yuanyuan , Ma Biao , Xue Dongbo , Sun Hezheng
Published: November 2021

Background:Breast cancer (BC) is one of the most common tumors in women. Recent years, immune checkpoint inhibitors (ICIs) have brought good news to BC patients. Although significant achievements have been made through treatment with ICIs, some people who experience serious immune-related adverse events (IrAEs) are still insensitive to this approach. The response to ICI treatment depends on the type of tumor microenvironment (TME). Methods:WGCNA (weighted gene co-expression network analysis), ESTIMATE algorithm, LASSO regression analysis, survival analysis, functional enrichment analysis are conducted to analyze the BC data in the TCGA database. Immunohistochemistry was used to verify the expression of CD52 in BC.Results:WGCNA and ESTIMATE algorithm found that the CD52 is closely related to the immune microenvironment. CD52 highly expressed in various breast cancer subtypes, and patients with high expression of CD52 have longer survival time. Compared with the low-CD52 group, the high-CD52 group had more immune cell infiltration. TIMER database verification results showed that CD8+ T cells, activated memory CD4 T cells, memory B cells, γδ T cells, and Tregs were positively correlated with CD52 expression, while M2 macrophages were negatively correlated. CD52 can change the trend of TIC (CD8+ T) and tumor-associated macrophage (TAM) infiltration with respect to the survival time of breast cancer patients. Based on the expression of CD52, we explored the relationship between CD52 and the adaptive immune response (AIR). CD52 is a marker of AIR stratification in breast cancer patients. We constructed a CD52-related adaptive immune response gene signature (CD52rAIRGsig) which is an independent prognostic factor for breast cancer and related to genome instability and the immune cells infiltration in the TME. CD52 and CD52rAIRGsig were associated with PD-1 signaling and immune checkpoint inhibitor markers, which proves that patients with high CD52 expression and low risk of CD52rAIRGsig are more suitable for ICI treatment. We then screened chemotherapeutics for personalized medicine based on CD52rAIRGsig. Conclusion:Therefore, we have discovered a new marker to guide the treatment and prognosis of breast cancer patients with ICIs. This provides a combined treatment strategy including different combinations of ICIs combined with chemotherapeutic drugs to treat breast cancer.
Factors Affecting Titanium Mesh Cage Subsidence in Single-level Anterior Cervical Corpectomy and Fusion for Ossification of the Posterior Longitudinal Ligament
Authors: Tang Yifan , Li Fengning , Geng Xiangwu , Jia Lianshun , Zhou Shengyuan , Chen Xiongsheng
Published: November 2021

Background: To analyze risk factors of titanium mesh cage (TMC) subsidence in single-level anterior cervical corpectomy and fusion (ACCF) for cervical ossification of the posterior longitudinal ligament (OPLL). Methods: Patients with cervical OPLL who were treated with single-level ACCF between January 2019 to December 2019 were retrospectively analyzed in two groups: patients with TMC subsidence as Group S, and patients with no TMC subsidence as Group N during the one-year follow-up period. The degree of distraction between decompression of the vertebral bodies and correction of the cervical curvature was measured to analyze their relationship with TMC subsidence. Results: There was no significant difference in patient demographics and complications between the two groups. The degree of distraction in Group S was significantly higher than that in Group N. The change of C2 to C7 Cobb angle (α) in Group S was significantly greater than that in Group N, and the interspinous process distance (SPD) in Group S was also significantly greater than that in Group N. The JOA score and JOA recovery rate were not statistically different between the two groups.Conclusions: Intraoperative selection of overlength TMC in single-level ACCF for OPLL, over-distraction, and excessive correction of the cervical curvature may cause TMC subsidence after surgery. No significant impact of TMC subsidence on the surgical outcome was observed during the 1-year follow-up period.
Circular RNA CDR1as Promotes Gastric Cancer Growth via miR-299-3p/TGIF1 Axis
Authors: Li Rong , Jiang Jiajia , Wang Junyi , Hou Jie , Wang Dongli , Qian Hui , Zhang Xu , Xu Wenrong
Published: November 2021

Background Gastric cancer (GC) is a common malignancy worldwide. Circular RNA CDR1as has been reported as a crucial regulator in human diseases including cancer. However, its biological roles, mechanisms and clinical values in GC remain largely unknown. Methods and Results CDR1as levels were surveyed in paired GC and adjacent normal tissues, paired blood samples from GC patients and healthy controls by RT-qPCR. Its clinical values were evaluated by ROC analysis, survival analysis and correlations with clinic pathological features. Cell transfection was performed to manipulate gene expression. In vitro CCK8 and colony formation assays and in vivo xenograft mouse model were employed to determine CDR1as effects on GC growth. CDR1as-miRNA and miRNA-mRNA interactions were predicted by bioinformatics analysis and further verified by RIP, dual-luciferase reporter gene assays, RT-qPCR, western blot and functional rescue experiments. Our results showed that CDR1as level was significantly downregulated in GC tissues and correlated with nerve invasion and poor prognosis. GC patients presented higher plasma CDR1as level than healthy controls. Functionally, knockdown of CDR1as inhibited GC cell proliferation and viability while its overexpression promoted GC growth in vitro and in vivo. The proliferation-related proteins PCNA and Cyclin D1 and apoptosis-related proteins Bax, Bcl-2, Caspase-3 and Caspase-9 were regulated. Mechanistically, CDR1as acted as a miR-299-3p sponge to relieve its suppressive effects and upregulate TGIF1 expression to promote GC growth.Conclusions CDR1as may be considered as a potential diagnostic and prognostic biomarker for GC. CDR1as/miR-299-3p/TGIF1 axis promotes GC growth in vitro and in vivo.
Factors Influencing Caregivers’ Health Seeking Behavior for Malaria Treatment of Children Under 5 Years in Busia Municipality, Uganda
Authors: Odimbe David Bwire , Atuhairwe Christine
Published: November 2021

Background: Malaria remains a serious cause of under-five mortality and morbidity worldwide and Uganda inclusive. This burden can be minimized by promptly seeking health care. In Uganda, however, studies around malaria health-seeking behaviors for under-five children in the most malaria prevalent areas are very few. This study aimed at determining the factors influencing caregivers’ health-seeking behavior for malaria treatment of children under five years in Busia Municipality, Uganda. Methods: A cross-sectional research design was used with a structured questionnaire to collect data. Data were analyzed using SPSS Version 22 to establish relationships between the variables. Results: The results showed that the current health-seeking behaviors of the caregivers of under-five children in Busia municipality are associated with caregiver education level (p= 0.008), the health worker’s behavior towards the client (p=0.015), the severity of fever (p<0.001), the severity of last malaria episode (p<0.001), waiting time (p=0.001), the quality of health services (p= 0.001) and age of caregiver (p<0.001). Traditional medicine and home remedies are the most utilized means of malaria management in under-five children in Busia Municipality. Conclusions: Caregivers need to be sensitized about the proper health-seeking behaviors for the management of malaria in children under-five years through radio shows, television, community engagement meetings among others to enhance the knowledge and understanding of communities about the recommended malaria treatment-seeking practices. There is a need to continuously train medical workers on client engagement skills to promote a good relationship with patients and encourage their return.
Community, conflict and conservation: response of mammalian fauna to ecological and anthropological correlates ‒ a critical habitat in Indo-Bhutan transboundary landscape urges multiagency cooperation
Authors: Nath Anukul , Lahkar Bibhuti P , Brahma Namita , Sarmah Pranjit , Das Arup Kr , Das Subhashish , Basumatary Thunu , Islary Rajual , Swargiary Anindya
Published: November 2021

The impacts of conflict on nature are devastatingly adverse but differ widely in different socio-political regimes. Armed conflict often facilitates illegal plunder and unsustainable use of natural resources, variously by rebel groups and impoverished or displaced people challenged with limited subsistence options. We studied the response of mammals in Ripu Reserve Forest (Assam) that suffers prolonged anthropogenic pressure due to armed conflict instigated by social unrest. We used standard single-season (spatial-dependence) occupancy models using sign survey to assess the factors affecting the space use of mammals and subsequently build capacity of conservation volunteers for long-term sustenance of Ripu. Our study revealed that Ripu has a high proportion of occupied area by prey species of large carnivores. Asian elephant, barking deer, and wild pig occupied most of the habitat, whereas gaur, sambar and spotted deer restricted themselves to selected patches within the Ripu. Common leopards found to be positively associated with prey occupancy. The studied mammals responded variably to different ecological and anthropological covariates and urge for species-specific management alongside landscape scale conservation approach. Our ground effort to strengthen community patrolling and operational execution of various alternative livelihood has helped to empower the economic condition of patrolling staff. Strategic implementation of law enforcement could support dispersal of tigers from Phibsoo WLS (Bhutan), potentially linked with the larger tiger and elephant landscape far west (Buxa Tiger Reserve) in the Terai region of India. Community-based conservation initiatives required continuous support from various agencies, including national, international, and local bodies, to restore this critical habitat.
Mapping the planet’s critical natural assets for people
Authors: Chaplin-Kramer Rebecca , Neugarten Rachel , Sharp Richard , Collins Pamela , Polasky Stephen , Hole David , Schuster Richard , Strimas-Mackey Matt , Mulligan Mark , Brandon Carter , Diaz Sandra , Fluet-Chouinard Etienne , Gorenflo Larry , Johnson Justin , Keys Patrick , Longley-Wood Kate , McIntyre Peter , Noon Monica , Pascual Unai , Liermann Cathrine Reidy , Roehrdanz Patrick , Schmidt-Traub Guido , Shaw Rebecca , Spalding Mark , Turner Will , Soesbergen Arnout van , Watson Reg
Published: November 2021

Sustaining the organisms, ecosystems, and processes that underpin human well-being is necessary to achieve sustainable development. Here we analyze 14 of nature’s contributions to people (NCP) for food, water, and climate security. Using spatial optimization, we identify critical natural assets, the most important ecosystems for providing NCP, comprising 30% (for local benefits) to 44% (for local and global benefits) of total global land area and 24% of national territorial waters. Many of these NCP are left out of international agreements focused on conserving species or mitigating climate change, yet our analysis shows that explicitly prioritizing critical natural assets jointly advances development, climate, and conservation goals. Crafting policy and investment strategies that protect critical natural assets is essential for sustaining human well-being and securing Earth’s life support systems.
Association between SNCA Intron and genetic predisposition to sporadic Parkinson's disease: a meta-analysis based on 49576 individuals
Authors: Li Peng , Fu Zuqiang , Yan Lei , Du Ming-yang , Wei-guoLiu
Published: November 2021

Background

The aetiology of Parkinson's disease (PD) is indistinct, but previous studies of different ethnicities have shown that genetic variations in synuclein alpha (SNCA) have an essential character in the risk of PD. The relation between SNCA intronic single nucleotide polymorphisms (SNPs) and the risk of PD is unclear. Based on the general population and five ethnic groups, this article managed a meta-analysis about the connection of SNCA intronic SNPs with the PD genetic predisposition.
Methods

This study was implemented according to the 24-step guideline, with strict criteria. The analysis was performed using Stata 16.0 software. Five genetic models were used to analyze the strength of the association, which was quantified by OR value and 95% CI.
Results

We included 15433 cases and 34143 controls from 31 articles. 6 SNPs in the intron region were screened, and 5 SNPs were statistically significant. Three variants augmented the PD susceptibility (rs2736990, rs3822086, and rs3857059), and two SNPs decreased the risk (rs356186 and rs7684318). Subgroup analysis showed that rs2736990 and rs3822086 carriers added the PD genetic predisposition in the East Asian group. European and Latin group carrying rs3857059 and rs2736990 is the high-risk populations of PD.
Conclusions

This study finally found 5 SNCA intronic SNPs related to the risk of PD. And racial factors should not be ignored.
Legendre-Galerkin Method, Dynamical System, and Optimal Control for Solving Covid-19 Model
Authors: Mahdy A. , lotfy khaled
Published: November 2021

The advancement of numerical demonstrating of irresistible illnesses is a key examination territory in different fields including the nature and the study of disease transmission. One point of these models is to comprehend the elements of conduct in irresistible infections. For the new strain of Covid (Coronavirus), there is no immunization to secure individuals and to forestall its spread up until now. All things being equal, control procedures related to medical services, for example, social separating, isolation, travel limitations, can be adjusted to control the pandemic of Coronavirus. This article reveals insights into the dynamical practices of nonlinear Coronavirus models dependent on strategy: the Legendre-Galerkin strategy. We summon a novel sign stream chart that is utilized to depict the Coronavirus model. Based on the Legendre-Galerkin method, the covid-19 model. Mathematica, as one of the world's leading computational software, was employed for the implementation of solutions. The proposed numerical techniques provide are excellent. Through our numerical investigations, it is uncovered that social removing between possibly tainted people who are conveying the infection and solid people can diminish or intrude on the spread of the infection. The mathematical reenactment results are insensible concurrence with the investigation forecasts. The free balance and dependability focus for the Coronavirus model is researched. Likewise, the presence of a consistently steady arrangement is demonstrate.
USE OF DOBUTAMINE STRESS ECHOCARDIOGRAPHY TO ASSESS MYOCARDIAL VIABILITY BEFORE PCI IN TOTAL OCCLUSION OF CORONARY ARTERY IN A TERTIARY CARE CENTRE
Authors: Rajge Harshad , Kale Keshav , Kane G.R. , Ghosh Roy Falguni
Published: November 2021

Dobutamine stress echocardiography has significant advantages in our country due to its wide availability, portability, low cost and safety.This study was conducted with the aim to assess myocardial viability by Dobutamine Stress Echocardiography (DSE) before PCI in total occlusion of coronary artery.This study confirms that a biphasic response to dobutamine is highly predictive of postoperative recovery of regional contractile function (100% at 6th week follow-up). This studies provide evidence that, at low doses, inotropic stimulation with P- receptor agonists will result in an increase in LV function in areas of viable myocardium but not in areas of myocardial necrosis.
EFFECT OF UTILIZING E-LEARNING AS A LEARNING MEDIA AND THE LEVEL OF DIGITAL LITERATURE ON STUDENT LEARNING OUTCOMES IN PRACTICUM COURSES
Authors:   Lecture, Information Management, STMIK Bina Patria, Magelang., Susilo Gatot , Sutiyatno Sukris ,   Lecture, Information System, STMIK Bina Patria, Magelang., Dewantoro Bambang ,   Lecture, Information Management, AMIK Jakarta Technology Cipta, Semarang.
Published: November 2021

The purpose of this study was to investigate the effect of using e-learning as a learning medium and the level of digital literacy on student learning outcomes in practicum courses. The research was conducted with a quantitative approach with a survey method. The population in this study were STMIK Bina Patria students. Data collection techniques were carried out by giving questionnaires to respondents. The results showed that the use of e-learning as a learning medium and the level of digital literacy had a significant effect on student learning outcomes for practicum courses, namely the variable utilization of e-learning had a significance value of 0.000 (p-value <0.05) and the variable digital literacy had a significant value. significance value of 0.035 (p-value <0.05). The impact of this research can be a means of alternative solution for lecturer to teach practicum courses and improve the outcome of students learning.
THE IMPACT OF TETFUND FUNDING ON THE SCHOLASTIC COMMITMENTS OF NIGERIAN LECTURERS
Authors:   Department of Library and Information Science Kogi State College of Education, Ankpa., O. Adubika Thomas
Published: November 2021

Education represents a vital tool for human and national development in the modern-day world. Perhaps, the tertiary institutions are the drivers of modern knowledge across the globe, hence, the need for continuous improvement of the higher education sector for quality knowledge. The involvement of the Tertiary Education Trust Fund in lifting the faces of tertiary education in Nigeria is yielding significant progress in attaining its purposes. The primary purpose of the present study was to investigate the impact of Tetfund grants on the academic commitment of Nigerian lecturers in pedagogical and research development. Eighty-three academic lecturers randomly selected from different tertiary institutions in Kogi State, Nigeria, participated in the study. The data for the study was collected using a self-developed instrument designed to ascertain the role of Tetfunds funding on the lecturers motivation and commitment to teaching and research. The finding of the simple regression analysis conducted revealed that Tetfund funding statistically significantly accounted for the variation in scholastic commitments of the lecturers. The study concludes that Tetfund grants are crucial in the development of quality education in Nigerias academia.
Assessment of the economic security in the Bryansk region based on an analysis of the region's socio-economic development indicators
Authors: Савинова Е.А.
Published: November 2021

Статья посвящена оценке показателей, характеризующих уровень социально-экономического развития Брянской области в динамике за 5 лет. На основе анализа ключевых показателей социально-экономического развития региона рассчитаны индикаторы экономической безопасности за период с 2016 по 2020 гг. Проведено сопоставление индикаторов с пороговыми значениями, определены угрозы региональной экономической безопасности. Предложен ряд мероприятий в производственной и социальной сферах, направленных на укрепление уровня региональной экономической безопасности Брянщины.

The article reveals issues related to the assessment of the level of socio-economic development of the Bryansk region over 5 years. The author analyzed the main indicators of the region's economy from 2016 to 2020 and calculated the key indicators of economic security, combined into blocks. A number of measures in the industrial and social spheres aimed at strengthening the level of regional economic security of The Bryansk region have been proposed.
REPRESENTAÇÕES CONCEITUAIS DE DOCENTES DO MERCOSUL ACERCA DA TRANSVERSALIDADE
Authors: Carrazoni  Lopes Viçosa Cátia Silene , Folmer Vanderlei , Fernandes Salgueiro Andréia Caroline
Published: November 2021

Este estudo propõe-se a investigar as concepções de docentes brasileiros, argentinos e uruguaios acerca da transversalidade na educação básica. Trata-se de uma pesquisa qualitativa de caráter exploratório. Participaram 96 docentes de escolas públicas situadas nas regiões periféricas de cidades que fazem parte da tríplice fronteira Brasil, Argentina e Uruguai. Os dados foram coletados por questionários, tratados e categorizados por meio da Análise de Conteúdo. Os resultados originam quatro categorias associadas: i) contextualização; ii) aprendizagem significativa; iii) formação de sujeitos; e iv) interdisciplinaridade. Os temas com maior frequência são semelhantes nos países pesquisados e estão relacionados ao Meio Ambiente e à Saúde. Quanto aos subsídios da formação continuada para o trabalho focado na transversalidade, o Uruguai destaca-se em relação à Argentina e ao Brasil. Conclui-se que as representações sobre transversalidade versam sobre transformação dos conceitos, explicitação de valores e inclusão de procedimentos vinculados ao cotidiano do educando. Assim, infere-se ser incipiente a inserção da transversalidade nas práticas educativas e nas formações continuadas da área fronteiriça visando ampliar os significados elaborados na construção do conhecimento, superar paradigmas tradicionais de ensino e aproximar os segmentos educacionais destes países.
Youth Migration in the Kemerovo Region (Kuzbass)
Authors: Morozova Elena , Kochneva Oksana
Published: November 2021

Youth migration is growing all over the world, including Russia and its regions. Migration is a natural process that cannot be stopped. However, excessive migration can deteriorate the socio-economic situation of the region that keeps losing its population. The research objective was to analyze the factors and motives behind the outflow of young people from the Kemerovo region, as well as to develop some measures that might help to reduce this process. The study was based on statistics and research data conducted by the Regional Sociological Center since 2015. The last two decades have seen a permanent decline in the local population, both due to natural causes and migration. The latter involves young people who leave their native region to study or work somewhere else in Russia or abroad. Potential migrants are driven by the lack of prospects for personal and professional development, the poor choice of attractive jobs, and their desire to live in larger and more comfortable cities. Young people flee from low salaries, bad ecology, poor conditions for cultural development, and low living standards. Therefore, young people believe that the migration can be stopped by higher salaries, more jobs, high-quality social services, better mortgage opportunities, more attractive conditions for self-development and leisure, a more stable economy, a better environmental situation, etc.
Development of Academic Technological Entrepreneurship in Russia
Authors: Korchagin Rudik
Published: November 2021

Technology entrepreneurs play a critical role in modern models of economic growth. At the same time, the features and development trajectories of technological entrepreneurship and gazelle firms in Russia differ from countries with mature market economies. The purpose of the article is to assess the state of academic technology entrepreneurship in Russian universities and to develop recommendations for its development. The methods of two-dimensional classification of universities according to two indicators of technological entrepreneurship development, correlation analysis, assessment of intergroup differences according to the Mann-Whitney U-criterion, qualitative analysis of entrepreneurial ecosystems in universities, methods of constructing algorithms were used. As a result, it was found that the number of start-ups and the likelihood of receiving commercial funding are practically not correlated. There is a group of universities that are not among the largest metropolitan universities, but have a high proportion of entrepreneurial projects that have successfully passed the seed stage and received commercial funding (business angel, venture fund). These top performing universities are distinguished not only by their innovative infrastructure, but also by a wide variety of community centers. Taking into account the results obtained an algorithm for the development of academic technological entrepreneurship on the basis of the university as an innovation hub has been developed. Its important elements are: pre-active marketing of scientific research groundwork, development of the social capital of the ecosystem, and collaboration practices. The results may be of interest to technology entrepreneurs themselves, as well as to universities interested in the development of academic entrepreneurship.
Uncertain time series forecasting method for the water demand prediction in Beijing
Authors: Li Haiyan , Wang Xiaosheng , Guo Haiying
Published: November 2021

Water demand prediction is crucial for effective planning and management of water supply systems to handle the problem of water scarcity. Taking into account the uncertainties and imprecisions within the framework of water demand forecasting, the uncertain time series prediction method is introduced for water demand prediction. Uncertain time series is a sequence of imprecisely observed values that are characterized by uncertain variables and the corresponding uncertain autoregressive model (UAR) is employed to describe it for predicting future values. The main contributions of this paper are shown as follows. Firstly, by defining the auto-similarity of uncertain time series, the identification algorithm of UAR model order is proposed. Secondly, a new parameter estimation method based on the uncertain programming is developed. Thirdly, the imprecisely observed values are assumed as the linear uncertain variables and a ratio-based method is presented for constructing the uncertain time series. Finally, the proposed methodologies are applied to model and forecast Beijing's water demand under different confidence levels and compared with the traditional time series, i.e. ARIMA method. The experimental results are evaluated on the basis of performance criteria, which shows that the proposed method outperforms over the ARIMA method for water demand prediction.
GERENCIAMENTO DE RESULTADOS CONTÁBEIS À LUZ DAS DIFERENÇAS ENTRE O LUCRO CONTÁBIL E TRIBUTÁRIO (BOOK-TAX DIFFERENCES): UMA ANÁLISE DE DADOS EM PAINEL BALANCEADO
Authors: Furtado Lorena Lucena , Souza João Antônio Salvador , Sarlo Neto Alfredo
Published: November 2021

Este artigo teve por objetivo analisar a influência das práticas tributárias como incentivos para o gerenciamento de resultados contábeis das empresas brasileiras. A amostra foi composta das companhias de capital aberto que possuíam ações negociadas na BM&FBovespa, perfazendo o período de 1999 a 2012. Para operacionalizar o estudo, foram geradas as estimativas tanto para o modelo de Jones modificado (1995), a fim de obter os accruals discricionários, quanto para o modelo desenvolvido por Tang (2006) modificado, a fim de captar a parte anormal relativa ao desalinhamento entre as regras contábeis e tributárias na apuração do lucro contábil e do lucro tributário (Book-Tax Differences). Os resultados revelaram que as práticas tributárias, adotadas pelas empresas, influenciaram em geral o gerenciamento de resultados praticados pelos gestores, sendo essa relação negativa. À luz desse fato, o mercado compreende que o maior alinhamento entre as formas de apuração do lucro contábil e tributário deteriora a fidedignidade dos números contábeis reportados pelas empresas.Palavras-chave: Gerenciamento de resultados contábeis; Book-Tax Differences; Lucro tributário.
Riscos e desastres relacionados a eventos extremos (climáticos e meteorológicos) no estado da Paraíba
Authors: Costa Jonatas Nascimento da , Silva Júnior Josué Barreto da , Araújo Sérgio Murilo Santos de
Published: November 2021

Os desastres caracterizam-se enquanto fenômenos excepcionais ou extremos que afetam diretamente uma dimensão social, econômica, ambiental, político-institucional, etc. Compreendendo a complexidade que envolve os riscos e desastres, o presente estudo, objetivou desenvolver uma analise dos eventos extremos (climáticos-meteorológicos) no estado da Paraíba, relacionando: registros oficiais, tipologias, condicionantes físicos-ambientais, intensidade dos fenômenos, dimensão social impactada, entre outros. Desta forma, constata-se a grande variabilidade tipológica de desastres atuantes no estado, com forte presença de eventos climáticos e meteorológicos. Assim foram identificados os seguintes eventos extremos: Enxurradas, Inundações, Alagamentos, Vendavais, Granizos, Trovoadas, e processos integrados de convecção
Expansão da fronteira agrícola sobre o Cerrado: o mapeamento do uso da terra no município de Diamantina - MT.
Authors: Avelino Edcassio Nivaldo
Published: November 2021

A expansão da fronteira agrícola no Centro-Oeste brasileiro deu-se por meio da transformação das áreas ocupadas pelo bioma Cerrado em terras de cultivos agrícolas ligados ao agronegócio. Este artigo tem o objetivo de elaborar o mapeamento do uso da terra, no contexto do município de Diamantino, estado de Mato Grosso. A pesquisa fundamentou-se nas concepções teóricas de Natureza (PORTO-GONÇALVES, 2006); Geografia Socioambiental (Mendonça, 2001); Sensoriamento Remoto (NOVO, 2008); e Sensoriamento Remoto da Vegetação (PONZONI, 2012), buscando aplicar a técnica de classificação supervisionada, método MAXVER sobre as cenas da imagem do satélite Landsat 8, sensor OLI,  órbita 227, ponto 70, de 17/09/2016. Os resultados mostraram que as lavouras com cultivo mecanizado ocupam 60,5% da área estudada enquanto o Cerrado florestal e savânico distribuem-se por 39,4%. Os resultados podem contribuir para a gestão territorial.
Estratégia para acurária de mapas de cobertura da terra no semiárido brasileiro: Estudo de caso no município de Martins/RN.
Authors: Fernandes Guedes Jânio Carlos , Cestaro Luiz Antonio
Published: November 2021

Estudos relacionados ao desenvolvimento sustentável e ao planejamento adequado dos recursos naturais são um dos desafios da sociedade atual, caracterizando padrões ambientais como, por exemplo, o levantamento da cobertura da terra. Com o advento das geotecnologias, estudos acerca da cobertura da terra, possibilitam gerar mapas distinguindo diferentes tipos de cobertura da terra. Por sua vez, a exatidão de um mapa é uma etapa primordial no final de qualquer classificação. A avaliação da acurácia de mapas, por sua vez, permite verificar erros oriundos da classificação. Pretende-se com este trabalho aplicar estratégias para verificar a acurácia de mapas de cobertura da terra. Para tanto, utilizou-se de um mapa de uso e cobertura da terra do município de Martins/RN, realizado pelo INPE em 2011, e o software ArcGis 10.2. Em campo foram observados e coletados às coordenadas de 125 pontos de controle, e posteriormente elaborado uma matriz de confusão e aplicados o índice de Exatidão Global e o índice Kappa. Em suma, a classificação do INPE obteve um índice de Exatidão Global de 55,20%, e um índice Kappa de 43,21%, enquadrando-se como “Boa” segundo Landis & Kock (1977).
Caracterização fitogeográfica em unidade de conservação como subsídio à proteção de espécies da Caatinga.
Authors: Balbino Cavalcante Márcio , Belarmino Alves Carlos Antônio , Ribeiro da Silva Ginaldo , Vieira de Arruda Luciene
Published: November 2021

Atualmente os estudos sobre a biogeografia e fitogegrafia são insuficientes na produção acadêmica da ciência geográfica. No caso desses estudos em Unidades de Conservação, ainda torna-se mais escassos, em especial, em área da caatinga nordestina. Diante do exposto, a presente pesquisa teve como objetivo caracterizar a fitogeografia do Parque Estadual da Pedra da Boca, localizado em Araruna - PB, como subsídio à proteção de espécies endêmicas do bioma caatinga da área. Sendo assim, a metodologia foi dividida em três etapas: pesquisa bibliográfica e documental, elaboração dos instrumentos de pesquisa de campo, trabalhos de campo, sistematização e análise dos dados. Diante dos resultados, o ambiente fitogeográfico do PEPB é de Savana Estépica nordestina - Caatinga, alcançando seus aspectos hipoxerófila e hiperxerófila. Na região, além da Caatinga, ainda se podem observar algumas espécies de mata serrana, vegetação do tipo subcaducifólia que aparece nas áreas mais úmidas, próximas às vertentes. Diante dos resultados, conclui-se que o Parque Estadual da Pedra da Boca por sua função precípua de proteção de recursos naturais, são fornecedoras de serviços ambientais por excelência a região. Entre elas a proteção da fauna e flora endêmica do bioma caatinga.
A Contribuição da Geodiversidade na prestação dos Serviços Ecossistêmicos do manguezal.
Authors: Oliveira Rabelo Thiara , Marques Santos Nayara , Félix da Silva Costa Diógenes , Leite do Nascimento Marcos Antônio , Carvalho Lima Zuleide Maria
Published: November 2021

Os Serviços Ecossistêmicos (SE) são bens tangíveis e intangíveis produzidos pelos ecossistemas, utilizados pela sociedade em busca do bem estar humano. Porém, mais recentemente tem se considerado a diversidade das características abióticas de uma paisagem para fins de conservação, ou seja, considerando a geodiversidade local e sua contribuição para a prestação destes serviços. O ecossistema manguezal caracteriza-se como uma área de elevada importância ecológica. Neste ambiente ocorrem áreas de intensos processos biológicos e geoquímicos, além de representar fonte de alimento e renda para populações ribeirinhas. Contudo, para que seja possível essa intensa produtividade, o manguezal depende do aporte de sedimentos fluviais e marinhos, oscilações da maré, redução da energia de ondas, relevo plano e etc. Considerando estes pressupostos, o objetivo deste trabalho foi analisar a importância de compreender a relação entre Geodiversidade e Serviços Ecossistêmicos, enfatizando a influência dos recursos abióticos na dinâmica de prestação dos serviços por este ecossistema.
Potential Papain-like Protease Inhibitors Against COVID-19: A Comprehensive
In Silico Based Review
Authors: Agrawal Neetu , Pathak Shilpi , Goyal Ahsas
Published: November 2021

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The entire world has been in a battle against the COVID-19 pandemic since its first appearance
in December 2019. Thus researchers are desperately working to find an effective and safe
therapeutic agent for its treatment. The multifunctional coronavirus enzyme papain-like protease
(PLpro) is a potential target for drug discovery to combat the ongoing pandemic responsible for
cleavage of the polypeptide, deISGylation, and suppression of host immune response. The present
review collates the in silico studies performed on various FDA-approved drugs, chemical compounds,
and phytochemicals from various drug databases and represents the compounds possessing
the potential to inhibit PLpro. Thus this review can provide quick access to a potential candidate to
medicinal chemists to perform in vitro and in vivo experiments who are thriving to find the effective
agents for the treatment of COVID-19.