bluuebunny/crossref_metadata_2025 huggingface dataset:
Density functional theory study of gas molecules inactivation pathway on pristine germanene nanosheet
Authors: Mukherjee Prajna , Kanungo Sudipta
Published: September 2024

By utilizing density functional theory, we investigated the adsorption of gas molecules (NO2 and SO2) on Germanene nanosheets (GeNS). Our findings reveal that GeNS displays notably high reactivity toward these gas molecules, with adsorption energies exceeding 1.00[Formula: see text]eV. The stability of GeNS at elevated temperatures and the thermodynamics of the adsorption process have been thoroughly investigated. These findings point toward promising applications for GeNS in the development of metal-free catalysts. Furthermore, the comprehensive examination of gas molecules inactivation pathways on GeNS enhances the understanding of its properties and opens avenues for exploring its potential as both catalysts and gas sensors.
A computational analysis on thermodynamic changes in liquid and solid states of carbon at liquid-liquid phase coexistence temperature
Authors: Gautam Arvind K. , Shukla Yashwant , Pingua Nandlal
Published: September 2024

The carbon is an important element which belongs to group 14 of the periodic table and shows multiple applications in our daily life as well as at the industrial scale. It is a promising element which represents the liquid–liquid phase transition (LLPT) phenomena. Additionally, it shows interesting anomalous behavior with some usual thermodynamic properties such as heat capacity ([Formula: see text]) near about the liquid–liquid phase coexistence temperature ([Formula: see text]). Hence, it is quite challenging and difficult to simulate carbon at or near the liquid–liquid phase coexistence temperature. This anomalous behavior also creates complications in computing the precise and equilibrated thermodynamic properties close to [Formula: see text]. Therefore, we have studied the thermodynamic behavior of liquid and solid (diamond) states of carbon at liquid–liquid phase coexistence temperature ([Formula: see text]) while transforming from liquid to solid state and achieving the equilibrated liquid and solid states individually. Additionally, we have also performed a similar analysis on melting temperature ([Formula: see text]) to compare the system trends and its thermodynamics behavior in liquid and solid states, respectively. Furthermore, all the predicted thermodynamic results are quite consistent and able to show the equilibrium changes at the liquid–liquid phase coexistence temperature ([Formula: see text]) and melting temperature ([Formula: see text]), respectively.
Synthesis and characterization of ZnO–NiO binary nanocomposites by hydrothermal technique for gas sensing and photocatalytic applications
Authors: Matthew D. F. , Ahemad Huda Imran , Aher Y. B. , Sonawane L. D. , More M. A. , Shinde S. D. , Jain G. H. , Ezema F. I. , Patil Ganesh E.
Published: September 2024

Inorganic photocatalytic materials exhibiting a highly efficient response to ultraviolet-visible light spectrum have become a subject of widespread global interest. Nanocomposite metal oxides, particularly Nickel Oxide (NiO) and Zinc Oxide (ZnO), have gained attention for their diverse applications in gas sensing and photocatalytic processes. In this work, ZnO-NiO (ZnO0.6NiO0.4 and ZnO0.4NiO0.6) binary nanocomposites were synthesized by hydrothermal technique. The binary nanocomposites were analyzed by UV-Visible spectrophotometer, X-ray diffraction (XRD), photoluminescence (PL), Fourier transform infrared spectrophotometer (FTIR), energy dispersive X-ray spectroscopy (EDX), field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM). The XRD pattern revealed that the nanocomposites, the peaks of both ZnO and NiO are present indicating the presence of both crystal structures hexagonal wurtzite and cubic. The miller indices, crystallite size, microstrain and dislocation density were determined from the XRD plot. FESEM and TEM analyses showed the spherical morphology of the synthesized composites with an approximate size of 10[Formula: see text]nm. The detailed analysis of ZnO–NiO binary nanocomposite sensor characteristics in terms of sensitivity, selectivity, response and recovery time were carried out and the nanocomposites were found to be highly sensitive to CO2 100 ppm at 350∘C and Cl2 at 200∘C. The photocatalytic degradation outcome showed 52% degradation of methylene blue at 10 ppm and 90[Formula: see text]w/m2. These results suggest the potential utility of these binary nanocomposites in photocatalytic applications for the degradation of organic pollutants.
Low-temperature sol–gel preparation of single-phase PbZrO3 ceramics
Authors: Zhang Yi , Zhang Xinyu , Qin Jiayi , Huang Xin , Wu Yilin , Wu Liang , Zhang Hui
Published: September 2024

Antiferroelectrics have recently captured widespread attention for their potential applications in energy storage capacitors, electronic and electrothermal devices. PbZrO3, being the first antiferroelectric discovered, remains the focus of antiferroelectric studies. Conventionally, the PbZrO3 ceramics were prepared via a high-temperature solid-state reaction method (higher than 1000∘C). Here, we report a simple sol–gel route to prepare single-phase PbZrO3 ceramic at a much lower calcination temperature of 600∘C. By using the single-phase PbZrO3 ceramics, thin films with outstanding antiferroelectric property showing well-defined double-hysteresis polarization switching were further obtained by pulsed laser deposition.
Comparative Analysis of Visual Field Characteristics and Perceptual Processing in Peripheral Vision Between Virtual Reality and Real World
Authors: Bürger Dan , Schley Marc-Kevin , Loerwald Hannes , Pastel Stefan , Witte Kerstin
Published: September 2024

In various domains, virtual reality (VR) has emerged as a valuable tool for simulating specific scenarios and facilitating training within controlled and secure conditions. As peripheral vision plays a crucial role in numerous contexts, it must be duly considered in VR simulations. However, while peripheral vision was examined in VR, comparisons between VR and the real world (RW) are rarely made. Therefore, this study is aimed at comparing RW and VR reaction times (RTs) to peripheral visual stimuli and the field of view (FOV). This comparison is achieved using the peripheral perception‐R (PP‐R) of the Vienna Test System and a programmed virtual replica. The virtual replica underwent additional testing, revealing good reliability for RTs but only moderate to poor for measurements of the participant’s FOV. The comparison between the two environments indicates slower RTs to peripheral visual stimuli in VR than in RW. This observed discrepancy is consistent with the results of previous studies investigating RTs to foveal stimuli and can be partially explained by the latencies in the hardware and software configurations used. Nevertheless, the observed correlations between the RTs in both conditions suggest comparable visual processing within the peripheral visual field and affirm the decent replication of the real PP‐R in VR. Overall, the study’s results support the usage of VR as a tool for practicing and examining specific scenarios, including peripheral vision. The discrepancies revealed in the RTs between VR and RW emphasize the need to continue examining hardware and software components in VR research.
Declining Time‐Trend in Loneliness Levels Among Migrant Children in Urban China, 2006−2019: A Cross‐Temporal Meta‐Analysis of 40 Studies Published From 2006 to 2022
Authors: Ge Lin-Feng , Wu Rui-Yao , Zhong Bao-Liang
Published: September 2024

Loneliness has long been a significant psychosocial problem for migrant children in urban China. In recent years, social changes and enhancements in social welfare equity have lessened the disadvantages faced by these migrant children. The current study investigated the time‐trend of loneliness levels among migrant children from 2006 to 2019. A literature search was performed within major Chinese‐ and English‐language databases, and studies that reported the means and standard deviations of Children’s Loneliness Scale (CLS) scores among Chinese migrant children were included in this cross‐temporal meta‐analysis. Weighted linear regression was conducted to examine the trend of mean CLS scores over the survey year, and Cohen’s d value was calculated to assess the magnitude of change. In total, 40 cross‐sectional studies conducted between 2006 and 2019 (published by 2022), consisting of 47 cohorts of migrant children and a total sample size of 17,090, were included. Overall, there was a significant downward trend between the survey year and mean CLS score (unstandardized coefficient [β] = −0.342, P  < 0.001), and Cohen’s d value of this decline from 2006 to 2019 was 0.411. Similar declining time‐trends were also observed among subgroups when broken down by sex, school type, and geographic regions (β = −0.182 to −0.589, P  < 0.001, d = 0.222–0.719). The loneliness levels of migrant children in urban China decreased from 2006 to 2019. Nevertheless, sustained measures and inclusive policies are still needed to mitigate the loneliness levels of Chinese migrant children.
Comparative Microstructural Evaluation of Wood in Three Dominant Ziziphus Species of Desert Ecosystem (Cholistan), Pakistan
Authors: Bilal Muhammad , Khan Zaheer-ud-din , Muhammad Sohaib , Hanif Uzma , Hussain Khalid , Tayyab Muhammad , Sardar Andleeb Anwar , Nawaz Hassan , Jawad Tariq Khan Muhammad , Mahrukh  , Rasool Aneela , Faisal Summiya , Zahid Muhammad
Published: September 2024

The present microstructural evaluation was carried out on the woods of three ethnobotanically important local fruit trees, namely, Ziziphus mauritiana Lam., Z. spina-christi (L.) Willd., and Z. nummularia (Burm.f.) Wight and Arn., of family Rhamnaceae from Cholistan Desert of Pakistan. Wood samples were sectioned with sliding sledge microtome to make permanent slides for observing different anatomical parameters under the light microscope. All selected species were observed to have diffuse‐porous wood with indistinct growth rings. The vessels were rounded in outline in all the species studied and found mostly solitary or in radial multiples of 2 in Ziziphus mauritiana and Z. nummularia, while in radial multiples of 2 to 5 in Z. spina-christi. The intervessel pits were scalariform to opposite. The rays were uniseriate in Ziziphus mauritiana, while mostly were biseriate in Ziziphus spina-christi. Simple perforation plates and diffuse, confluent, and vasicentric types of axial parenchyma were present in all the selected species. The fibers were thin‐walled and nonseptate. One‐way ANOVA followed by the Tukey test was conducted to observe different anatomical variations within selected species. Principal component analysis revealed correlations among studied anatomical parameters. The number of rays per mm was comparatively larger in Ziziphus nummularia, showing its greater susceptibility to wood‐deteriorating agents than in other selected species. The Runkel ratio indicated the selected species suitable for making paper.
In Vitro Evaluation of α‐Glucosidase and α‐Amylase Inhibition in Thai Culinary Vegetables
Authors: Ratananikom Khakhanang , Juntaree Vichayut , Wichaiyo Woragon , Khunluek Kris , Premprayoon Kantapon , Kubola Jittawan
Published: September 2024

Diabetes management through dietary intervention has gained significant interest, particularly in the use of natural plant‐based inhibitors of key enzymes involved in carbohydrate digestion. The objective of this study was to assess the inhibitory effects of ten Thai culinary vegetables on α‐glucosidase and α‐amylase, including Chinese chive (Allium tuberosum), holy basil (Ocimum tenuiflorum), star gooseberry (Phyllanthus acidus), galangal (Alpinia galanga), bamboo grass (Tiliacora triandra), Turkey berry (Solanum torvum), cassod tree (Senna siamea), dill (Anethum graveolens L.), noni (Morinda citrifolia), and pearl wattle (Leucaena leucocephala). All vegetables were extracted using deionized water at a 1 : 10 ratio in an ultrasonic bath operating at 350 W and a frequency of 50 Hz for 30 minutes. The α‐glucosidase inhibitory activities of the vegetable extracts ranged from 13.42 ± 0.23% to 79.84 ± 0.47%, while the inhibitory activities against α‐amylase were relatively modest, ranging from 4.82 ± 3.32% to 27.49 ± 1.67%. Cassod tree exhibited the highest α‐glucosidase inhibition with the lowest IC50 at 126.38 ± 0.98 μg/mL, followed by galangal (203.17 ± 1.05 μg/mL) and holy basil (1,240 ± 20.31 μg/mL), respectively. These results may hold promise for encouraging the consumption of vegetables as a strategy for diabetes management through the targeting of key enzyme inhibition.
Synthesis of Hydrogel Based on Poly (Acrylic Acid–Co‐Vinyl Acetate) Grafted on Modified Recycled Cellulose for Use in Fertilizer Slow‐Release System
Authors: Nazeri Soheila , Najafi Moghadam Peyman
Published: September 2024

The aim of this work is a synthesis of suitable hydrogel to produce slow‐release fertilizer using recycled cellulose which is obtained from waste paper. For this purpose, initially, we extracted alpha cellulose from waste paper and modified it to obtain carboxymethyl cellulose (CMC). Then, the CMC was converted to a suitable hydrogel through in situ graft copolymerization of acrylic acid and vinyl acetate in the presence of methylene bisacrylamide as a crosslinker. The various factors that affect hydrogel synthesis, such as the amounts of CMC, monomers, initiator, and crosslinker, were evaluated. In the optimized formulation, the weight ratio of monomers to CMC is 7, the molar ratio of monomers to each other is 1, and the crosslinker is used as 3 molar percent of monomers. The products were characterized using Fourier transform infrared, thermal gravimetric analysis, and scanning electron microscope analyses. The swelling behavior of the synthesized hydrogels was evaluated in different environments, such as distilled water, tap water, salt water, and different pH levels. The swelling ratio increases with an increase in pH level. Between the synthesized hydrogels, the best one was selected for slow‐release fertilizer production and loaded with 20‐20‐20 fertilizer (NPK), and the release behavior was evaluated. In an alkaline pH, there was a long time for NPK release within a slow‐release medium and even after 361 h, the release process was continued. Also, the performance of the fertilizer‐loaded hydrogel in soil using water holding capacity and water retention ratio tests were evaluated.
The Effect of Okra Seed (Abelmoschus esculentus) Powder Supplementation on Nutritional, Textural, Microstructural, and Sensory Properties of Gluten‐Free Muffins
Authors: Sahan Altan , Ozgoren Capraz Ezgi
Published: September 2024

Celiac disease is an autoimmune‐mediated systemic disorder that develops in those who are genetically predisposed, the management of which is limited to a lifelong gluten‐free diet. Gluten‐free foods contain fewer proteins, dietary fiber, and minerals than their gluten counterparts. Among the appropriate ingredients, okra seed is known for its high protein, fat, and dietary fiber content, its well‐balanced amino acid composition, and its rich unsaturated fatty acid profile. In the present study, muffins were prepared with part of the rice flour substituted by okra seed powder (OSP) (15, 30, and 45%) and the nutritional, textural, microstructural, and sensory properties of the gluten‐free muffins were evaluated. The most preferred formulation was determined using the integrated SWARA‐TOPSIS multicriteria decision‐making method, revealing the 30% OSP‐added muffin to be the optimum alternative, with 2.43% ash, 28.01% fat, 10.0% protein, 7.39% total dietary fiber, and 49.75 mg GAE/100 g total phenolic content. In a mineral matter analysis, the Mg, P, K, Ca, Mn, Fe, and Zn contents of the 30% OSP‐added sample were found to be 4.3, 1.2, 2.3, 2.7, 1.4, 4.9, and 2.0 times higher than the control sample, respectively. The OSP‐added gluten‐free muffin samples were also found to be an important source of essential and nonessential amino acids and a good source of linoleic and oleic acids. All of the muffin samples received acceptable sensory scores (>4/7). A texture profile analysis revealed that the hardness, adhesiveness, gumminess, and chewiness values of the muffins increased with the supplementation of OSP, while scanning electron microscope imaging revealed a homogeneous pore structure in the control samples that decreased as the OSP substitution rate increased. The results of the study revealed OSP to be an appropriate natural source of protein and dietary fiber in gluten‐free muffin production.
Supplementary Figure 4 from Therapeutic Efficacy of IL7/CCL19-Expressing CAR-T Cells in Intractable Solid Tumor Models of Glioblastoma and Pancreatic Cancer
Authors: Ohta Keisuke , Sakoda Yukimi , Adachi Keishi , Shinozaki Taro , Nakajima Masao , Yasuda Hiroyuki , Nagano Hiroaki , Tamada Koji
Published: September 2024

Supplementary Figure 4. Generation and characterization of anti-HER2 CAR-T cells expressing IL-7 and CCL19.
Supplementary Figure 3 from Therapeutic Efficacy of IL7/CCL19-Expressing CAR-T Cells in Intractable Solid Tumor Models of Glioblastoma and Pancreatic Cancer
Authors: Ohta Keisuke , Sakoda Yukimi , Adachi Keishi , Shinozaki Taro , Nakajima Masao , Yasuda Hiroyuki , Nagano Hiroaki , Tamada Koji
Published: September 2024

Supplementary Figure 3. Immunophenotypic analyses of 7×19 CAR-T.
Figure 6 from Therapeutic Efficacy of IL7/CCL19-Expressing CAR-T Cells in Intractable Solid Tumor Models of Glioblastoma and Pancreatic Cancer
Authors: Ohta Keisuke , Sakoda Yukimi , Adachi Keishi , Shinozaki Taro , Nakajima Masao , Yasuda Hiroyuki , Nagano Hiroaki , Tamada Koji
Published: September 2024

Potent therapeutic effects of patient’s PBMC-derived 7 × 19 CAR-T in autologous pancreatic cancer organoids. A, Tumor mass was established in NOG-ΔMHC by subcutaneous inoculation with 1 × 106 pancreatic cancer organoids. After 88 days, the established tumor mass was resected and examined for HER2 expression by IHC staining. B and C, NOG-ΔMHC mice were inoculated subcutaneously with 1 × 106 pancreatic cancer organoids on day 0 and then treated with intravenous injection of 5 × 106 anti-HER2 Conv. CAR-T or 7 × 19 CAR-T cells on day 10 or (left) untreated. Thereafter, the tumor size (B) and the mouse survival (C) were assessed (n = 5 each in all groups, biological replicates). **, P < 0.01; ***, P < 0.001.
Figure 5 from Therapeutic Efficacy of IL7/CCL19-Expressing CAR-T Cells in Intractable Solid Tumor Models of Glioblastoma and Pancreatic Cancer
Authors: Ohta Keisuke , Sakoda Yukimi , Adachi Keishi , Shinozaki Taro , Nakajima Masao , Yasuda Hiroyuki , Nagano Hiroaki , Tamada Koji
Published: September 2024

In vitro responses of autologous Conv. and 7 × 19 CAR-T against patient-derived pancreatic cancer organoids. A, Surface expression of endogenous HER2 was assessed in patient-derived pancreatic cancer organoids by flow cytometry. Open and filled histograms indicate staining with humanized anti-HER2 Ab and nonstaining, followed by anti–human IgG Ab, respectively. B–D, Anti-HER2 Conv. or 7 × 19 CAR-T or UTD was cocultured with HER2-positive pancreatic cancer organoids at an effector to target (E:T) ratio of 1:1 for 4 days. B, Morphologic images after 4 days of coculture. C, The number of residual tumor cells after coculture was analyzed by flow cytometry. Data are shown as mean ± SD of triplicate samples. D, The supernatants were harvested after 4 days of coculture, and the concentration of IFNγ was assessed by ELISA. Data are shown as mean ± SD of triplicate samples. **, P < 0.01; ***, P < 0.001; N.D., not detected.
Figure 3 from Therapeutic Efficacy of IL7/CCL19-Expressing CAR-T Cells in Intractable Solid Tumor Models of Glioblastoma and Pancreatic Cancer
Authors: Ohta Keisuke , Sakoda Yukimi , Adachi Keishi , Shinozaki Taro , Nakajima Masao , Yasuda Hiroyuki , Nagano Hiroaki , Tamada Koji
Published: September 2024

Massive infiltration of T cells and tumor cell lysis in the tumor tissues by the treatment with 7 × 19 CAR‐T. NOG‐ΔMHC mice were inoculated subcutaneously with 3.5 × 106 U87MG EGFRvIII cells on day 0, followed by intravenous injection of 1 × 107 UTD, Conv. CAR‐T, or 7 × 19 CAR‐T cells on day 10. Tumor tissues were resected from the mice on day 13 to prepare formalin-fixed, paraffin-embedded slices for H&E and IHC staining using rabbit anti–human CD4, CD8, CCR7, caspase-3 mAbs and mouse anti–human EGFRvIII mAb. Stained cells were visualized and observed by microscopic examinations at ×100 and ×400 magnifications. A, Representative images are displayed. Scale bar indicates a length of 200 μm (×100) or 50 μm (×400). B, The number of stained cells per tumor area (mm2) or the percentage of the stained area was calculated using BZ‐X analyzer software. Data are shown as mean ± SD of triplicate samples (n = 3 each per group, biological replicates). *, P < 0.05; **, P < 0.01; ***, P < 0.001; n.s., not significant.
Figure 2 from Therapeutic Efficacy of IL7/CCL19-Expressing CAR-T Cells in Intractable Solid Tumor Models of Glioblastoma and Pancreatic Cancer
Authors: Ohta Keisuke , Sakoda Yukimi , Adachi Keishi , Shinozaki Taro , Nakajima Masao , Yasuda Hiroyuki , Nagano Hiroaki , Tamada Koji
Published: September 2024

Potent therapeutic effects of 7 × 19 CAR-T in the preestablished solid tumor model of human glioblastoma. NOG-ΔMHC mice were inoculated subcutaneously with 3.5 × 106 U87MG EGFRvIII tumor cells on day 0 and then treated with intravenous injection of 1 × 107 Conv. CAR-T, 7 × 19 CAR-T, or UTD on day 10. Thereafter, the tumor size (A) and the mouse survival (B) were assessed (n = 12 each in UTD and 7 × 19 CAR-T groups; n = 13 in Conv. CAR-T group; n values are biological replicates). In A, each line indicates the tumor volume of an individual mouse. Tumor volumes during the initial 56 days of 7 × 19 CAR-T–treated mice are shown in the inset. ***, P < 0.001.
Supplementary Table 4 from Role of Forkhead Box P3 in IFNγ-Mediated PD-L1 Expression and Bladder Cancer Epithelial-to-Mesenchymal Transition
Authors: Zhang Hanwei , Ly Ann , Chou Emily , Wang Liang , Zhang Paul , Prado Kris , Gu Yiqian , Pellegrini Matteo , Chin Arnold I.
Published: September 2024

Genes and level of expression by z score of 271 IFNgamma induced and FOXP3-dependent genes
Supplementary Table 3 from Role of Forkhead Box P3 in IFNγ-Mediated PD-L1 Expression and Bladder Cancer Epithelial-to-Mesenchymal Transition
Authors: Zhang Hanwei , Ly Ann , Chou Emily , Wang Liang , Zhang Paul , Prado Kris , Gu Yiqian , Pellegrini Matteo , Chin Arnold I.
Published: September 2024

FDRs and p-values of FOXP3-dependent genes
Supplementary Table 1 from Role of Forkhead Box P3 in IFNγ-Mediated PD-L1 Expression and Bladder Cancer Epithelial-to-Mesenchymal Transition
Authors: Zhang Hanwei , Ly Ann , Chou Emily , Wang Liang , Zhang Paul , Prado Kris , Gu Yiqian , Pellegrini Matteo , Chin Arnold I.
Published: September 2024

GSEA FDR and p-values
Supplementary Figure 6 from Role of Forkhead Box P3 in IFNγ-Mediated PD-L1 Expression and Bladder Cancer Epithelial-to-Mesenchymal Transition
Authors: Zhang Hanwei , Ly Ann , Chou Emily , Wang Liang , Zhang Paul , Prado Kris , Gu Yiqian , Pellegrini Matteo , Chin Arnold I.
Published: September 2024

Generation of MB49 FOXP3 knockout cells by flow cytometry and Western blot. Immunofluorescence of chromogranin A and NSE.
Supplementary Figure 5 from Role of Forkhead Box P3 in IFNγ-Mediated PD-L1 Expression and Bladder Cancer Epithelial-to-Mesenchymal Transition
Authors: Zhang Hanwei , Ly Ann , Chou Emily , Wang Liang , Zhang Paul , Prado Kris , Gu Yiqian , Pellegrini Matteo , Chin Arnold I.
Published: September 2024

Composite Z-scores of FOXP3-dependent IFNgamma-inducible genes in HT1376 cells
Supplementary Figure 2 from Role of Forkhead Box P3 in IFNγ-Mediated PD-L1 Expression and Bladder Cancer Epithelial-to-Mesenchymal Transition
Authors: Zhang Hanwei , Ly Ann , Chou Emily , Wang Liang , Zhang Paul , Prado Kris , Gu Yiqian , Pellegrini Matteo , Chin Arnold I.
Published: September 2024

Dependency on FOXP3 in IFNgamma- and cisplatin-mediated PD-L1 expression in SW780 cells
Supplementary Figure 1 from Role of Forkhead Box P3 in IFNγ-Mediated PD-L1 Expression and Bladder Cancer Epithelial-to-Mesenchymal Transition
Authors: Zhang Hanwei , Ly Ann , Chou Emily , Wang Liang , Zhang Paul , Prado Kris , Gu Yiqian , Pellegrini Matteo , Chin Arnold I.
Published: September 2024

Complete Western blot membranes for respective figures
Supplemental Table S7 from Secondary Endpoint Utilization and Publication Rate among Phase III Oncology Trials
Authors: Beck Esther J. , Sherry Alexander D. , Florez Marcus A. , Kouzy Ramez , Abi Jaoude Joseph , Lin Timothy A. , Miller Avital M. , Passy Adina H. , Kupferman Gabrielle S. , Patel Roshal R. , Chino Fumiko , Higbie Victoria Serpas , Parseghian Christine M. , Overman Michael J. , Minsky Bruce D. , Thomas Charles R. , Tang Chad , Msaouel Pavlos , Ludmir Ethan B.
Published: September 2024

Full multivariable model evaluating the association between the number of SEPs and the percentage of SEPs published among sensitivity analysis SEPs from both the protocol and ClinicalTrials.Gov, from trials with multiple protocols available.
Table S5 from High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial
Authors: Paller Channing J. , Zahurak Marianna L. , Mandl Adel , Metri Nicole A. , Lalji Aliya , Heath Elisabeth , Kelly William K. , Hoimes Christopher , Barata Pedro , Taksey Jason , Garrison Dominique A. , Patra Kartick , Milne Ginger L. , Anders Nicole M. , Nauroth Julie M. , Durham Jennifer N. , Marshall Catherine H. , Markowski Mark C. , Eisenberger Mario A. , Antonarakis Emmanuel S. , Carducci Michael A. , Denmeade Samuel R. , Levine Mark
Published: September 2024

Table S5 shows AEs with Attribution Possible, Probable or Definite to Treatment (HDVIC or Placebo) listed by types and grades
Table S4 from High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial
Authors: Paller Channing J. , Zahurak Marianna L. , Mandl Adel , Metri Nicole A. , Lalji Aliya , Heath Elisabeth , Kelly William K. , Hoimes Christopher , Barata Pedro , Taksey Jason , Garrison Dominique A. , Patra Kartick , Milne Ginger L. , Anders Nicole M. , Nauroth Julie M. , Durham Jennifer N. , Marshall Catherine H. , Markowski Mark C. , Eisenberger Mario A. , Antonarakis Emmanuel S. , Carducci Michael A. , Denmeade Samuel R. , Levine Mark
Published: September 2024

Table S4 shows Adverse Events Included in the Co-primary Endpoint: Worst Grade by Patient
Supplemental Table S5 from Secondary Endpoint Utilization and Publication Rate among Phase III Oncology Trials
Authors: Beck Esther J. , Sherry Alexander D. , Florez Marcus A. , Kouzy Ramez , Abi Jaoude Joseph , Lin Timothy A. , Miller Avital M. , Passy Adina H. , Kupferman Gabrielle S. , Patel Roshal R. , Chino Fumiko , Higbie Victoria Serpas , Parseghian Christine M. , Overman Michael J. , Minsky Bruce D. , Thomas Charles R. , Tang Chad , Msaouel Pavlos , Ludmir Ethan B.
Published: September 2024

Full multivariable model evaluating the association between nonsignificant trial-level factors and the percentage of SEPs published.
Table S2 from High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial
Authors: Paller Channing J. , Zahurak Marianna L. , Mandl Adel , Metri Nicole A. , Lalji Aliya , Heath Elisabeth , Kelly William K. , Hoimes Christopher , Barata Pedro , Taksey Jason , Garrison Dominique A. , Patra Kartick , Milne Ginger L. , Anders Nicole M. , Nauroth Julie M. , Durham Jennifer N. , Marshall Catherine H. , Markowski Mark C. , Eisenberger Mario A. , Antonarakis Emmanuel S. , Carducci Michael A. , Denmeade Samuel R. , Levine Mark
Published: September 2024

Table S2 shows Association of HDIVC Treatment with PSA Response Adjusting for Prior Docetaxel Exposure
Supplemental Table S4 from Secondary Endpoint Utilization and Publication Rate among Phase III Oncology Trials
Authors: Beck Esther J. , Sherry Alexander D. , Florez Marcus A. , Kouzy Ramez , Abi Jaoude Joseph , Lin Timothy A. , Miller Avital M. , Passy Adina H. , Kupferman Gabrielle S. , Patel Roshal R. , Chino Fumiko , Higbie Victoria Serpas , Parseghian Christine M. , Overman Michael J. , Minsky Bruce D. , Thomas Charles R. , Tang Chad , Msaouel Pavlos , Ludmir Ethan B.
Published: September 2024

Full multivariable model evaluating the association between significant trial-level factors and the percentage of SEPs published.
Table S17 from High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial
Authors: Paller Channing J. , Zahurak Marianna L. , Mandl Adel , Metri Nicole A. , Lalji Aliya , Heath Elisabeth , Kelly William K. , Hoimes Christopher , Barata Pedro , Taksey Jason , Garrison Dominique A. , Patra Kartick , Milne Ginger L. , Anders Nicole M. , Nauroth Julie M. , Durham Jennifer N. , Marshall Catherine H. , Markowski Mark C. , Eisenberger Mario A. , Antonarakis Emmanuel S. , Carducci Michael A. , Denmeade Samuel R. , Levine Mark
Published: September 2024

Table S17 shows Comparison of F2-Isoprostanes Control and Intervention Changes 60 minutes after Cycle 6
Supplemental Table S2 from Secondary Endpoint Utilization and Publication Rate among Phase III Oncology Trials
Authors: Beck Esther J. , Sherry Alexander D. , Florez Marcus A. , Kouzy Ramez , Abi Jaoude Joseph , Lin Timothy A. , Miller Avital M. , Passy Adina H. , Kupferman Gabrielle S. , Patel Roshal R. , Chino Fumiko , Higbie Victoria Serpas , Parseghian Christine M. , Overman Michael J. , Minsky Bruce D. , Thomas Charles R. , Tang Chad , Msaouel Pavlos , Ludmir Ethan B.
Published: September 2024

Distribution of the percentage of PROs published per trial.
Table S13 from High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial
Authors: Paller Channing J. , Zahurak Marianna L. , Mandl Adel , Metri Nicole A. , Lalji Aliya , Heath Elisabeth , Kelly William K. , Hoimes Christopher , Barata Pedro , Taksey Jason , Garrison Dominique A. , Patra Kartick , Milne Ginger L. , Anders Nicole M. , Nauroth Julie M. , Durham Jennifer N. , Marshall Catherine H. , Markowski Mark C. , Eisenberger Mario A. , Antonarakis Emmanuel S. , Carducci Michael A. , Denmeade Samuel R. , Levine Mark
Published: September 2024

Table S13 shows Comparison of F2-Isoprostanes at Baseline between Treatment and Control Arms
Table S11 from High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial
Authors: Paller Channing J. , Zahurak Marianna L. , Mandl Adel , Metri Nicole A. , Lalji Aliya , Heath Elisabeth , Kelly William K. , Hoimes Christopher , Barata Pedro , Taksey Jason , Garrison Dominique A. , Patra Kartick , Milne Ginger L. , Anders Nicole M. , Nauroth Julie M. , Durham Jennifer N. , Marshall Catherine H. , Markowski Mark C. , Eisenberger Mario A. , Antonarakis Emmanuel S. , Carducci Michael A. , Denmeade Samuel R. , Levine Mark
Published: September 2024

Table S11 shows FACT-P Change (on Study Minus Baseline) Scores
Data from Therapeutic Efficacy of IL7/CCL19-Expressing CAR-T Cells in Intractable Solid Tumor Models of Glioblastoma and Pancreatic Cancer
Authors: Ohta Keisuke , Sakoda Yukimi , Adachi Keishi , Shinozaki Taro , Nakajima Masao , Yasuda Hiroyuki , Nagano Hiroaki , Tamada Koji
Published: September 2024

Abstract
Cancer immunotherapy using immune checkpoint inhibitors and its combination with other anticancer therapies has emerged as a new standard of care because of the encouraging therapeutic effects in various solid cancers. Nonetheless, glioblastoma and pancreatic cancer remain resistant to immunotherapy and represent intractable cancers with the poorest prognosis. We investigated the therapeutic effects of next-generation chimeric antigen receptor (CAR) T cells producing IL7 and chemokine (C–C motif) ligand 19 (CCL19; referred to as 7 × 19 CAR-T) in these intractable cancers. Cytotoxic activities and therapeutic effects of 7 × 19 CAR-T were evaluated in vitro and in vivo, in a model using EGFR variant III (EGFRvIII)–positive glioblastoma and anti-EGFRvIII CAR-T generated from healthy donor peripheral blood mononuclear cells (PBMC), or a model using HER2-positive pancreatic cancer organoids and anti-HER2 CAR-T generated from the same patient’s PBMC. Anti-EGFRvIII 7 × 19 CAR-T exhibited cytotoxic activity specific to EGFRvIII-positive tumor, induced complete rejection of glioblastoma with massive T-cell infiltration and tumor cell death in the tumor tissues, and consequently prolonged mouse survival. Anti-HER2 7 × 19 CAR-T demonstrated a potent cytotoxic activity against autologous HER2-positive pancreatic cancer organoids and induced complete rejection of autologous tumor along with prolonged mouse survival. Our results suggest that 7 × 19 CAR-T could become a therapeutic option for glioblastoma and pancreatic cancer. To the best of our knowledge, this is the first study to demonstrate the therapeutic efficacy of next-generation CAR-T in an autologous model using patient-derived tumor organoids and CAR-T generated from the same patient’s PBMC, in which unwanted allogeneic immune responses are fully excluded.
Significance:
Despite the clinical development of CAR T-cell therapy, its efficacy in solid cancers has yet to be established. This study explored the therapeutic potential and immunologic mechanisms of IL7/CCL19-producing CAR-T therapy in preclinical solid cancer models of glioblastoma and pancreatic cancer. We found that IL7/CCL19-producing CAR-T cells generated from the patient’s PBMC showed potent therapeutic effects against the solid cancer model established by inoculating organoids from the autologous tumor tissue.
Comparison of Hidden Blood Loss between Laparoendoscopic Single-Site Myomectomy and Conventional Laparoscopic Myomectomy
Authors: Tao Jiayu , Zhu Sennan , Chen Ziqi , Chen Qiuyu , Du Wenzhuo , Sun Jindan , Yu Mengqi , Zhou Yi , Zhao Yu , Zhang Qiong
Published: September 2024

Objective: Laparoendoscopic single-site myomectomy (LESS-M) is widely applied for the treatment of uterine leiomyoma. The purposes of this study were to investigate differences in hidden blood loss between LESS-M and conventional laparoscopic myomectomy (CLM) during treatment of uterine leiomyoma and to identify the associated risk factors. Design: This is a retrospective study. Participants: The participants of this study were patients who underwent laparoscopic myomectomy (114 and 156 for LESS-M and CLM, respectively) between July 1, 2019, and October 10, 2020, at the Second Affiliated Hospital of Wenzhou Medical University. Setting: The study was conducted at the Second Affiliated Hospital of Wenzhou Medical University. Methods: We enrolled a total of 114 and 156 patients who were treated with LESS-M and CLM, respectively, between July 1, 2019, and October 10, 2020. We collected clinical data, then applied the Nadler and Gross formula and multiple linear regression analysis to calculate the HBL and identify the associated risk factors, respectively. Results: Patients in the LESS-M group had a VBL of 115.4 ± 180.6 mL and an HBL of 364.3 ± 252.6 mL, accounting for 74.4 ± 22.4% of true TBL. On the other hand, patients in the CLM group had VBL of 187.9 ± 198.5 mL, and HBL of 306.8 ± 304.7 mL, accounting for 58.9 ± 30.2% of true TBL. HBL was significantly higher in the LESS-M than the CLM group (p = 0.000). Limitations: This study was the small sample size used. Conclusions: HBL accounted for a significant percentage of TBL in laparoscopic myomectomy, especially in patients treated with LESS-M. Paying attention to perioperative blood changes coupled with fully understanding HBL might promote postoperative recovery of patients.
“Flux in the Belly:” A History of Infantile Gastroenteritis
Authors: Obladen Michael
Published: September 2024

Background: Although a major cause of infant mortality for centuries, little research was done on the causes of infants’ diarrhea. Artificial feeding, teething, and summer heat were believed to cause the severe disease that spared breastfed infants. Summary: Since antiquity, infants’ digestive disorders were termed dyspepsia, flux of the belly, diarrhea, gastroenteritis, watery gripes, the runs, dysentery, or cholera, without definitions. Alois Bednar discerned 3 grades (dyspepsia, diarrhea, and cholera) of the same disease. Infants’ neurologic symptoms were interpreted as alimentary toxicosis. Chronic diarrhea caused emaciation and dehydration. In 1950, Laurence Finberg found diarrhea with hypernatremia causing cerebral damage. Seasonal influence was known since Hippocrates. Baudelocque recommended obtaining infant milk fresh from the cow because it decomposes in the summer heat. In the cities, summer diarrhea caused a third of total infant mortality. Physicians debated whether heat acted directly on the infant or spoiled the food. The discovery of microorganisms in the 1860s revolutionized medical understanding. However, influential researchers such as Adalbert Czerny classified nutritional disturbances by assumed pathogenesis (“ex alimentation, ex infection, ex constitution”), but denied the possibility of bacterial infection via milk. Heating baby food, practiced for centuries, was introduced in Denmark, Sweden, and France, whereas in Britain and Germany, professional and public debate on pasteurization persisted. Key Messages: It took half a century to implement effective hygienic measures once the bacterial origin became known. Foodborne infection was rejected, and the prejudice that raw milk possesses essential “living” properties, adopted by influential scientists, contributed to delaying pasteurization.
Artistic Expertise and Free Viewing of Modern Art
Authors: Sorek Yishai , Nahari Tal , Pertzov Yoni
Published: September 2024

Visual art and vision science had long been intertwined, both revealing and sharing countless insights on human vision over their respective histories. Deep artistic experiences and extensive artistic knowledge are often associated with “artistic expertise,” which in vision science traditionally echoes visual expertise from other professional domains (e.g., medicine, sports, driving). However, unlike other visual domains, artistic experiences involve more spontaneous and imaginative aspects, and no explicit success parameters. We hypothesized that viewing of artworks would lead to nuanced effects of expertise that may differ from other types of visual expertise. In our study, art experts and non-experts observed modern paintings and were free to view them within a relatively long time window. Higher expertise in art was associated with viewing modern paintings for significantly longer durations, and liking the paintings significantly more. However, contrary to other visual expertise studies, eye movement patterns exhibited little to no effect of artistic expertise. Based on these findings, we suggest a recontextualization of visual artistic expertise and discuss potential research directions, alongside methodological challenges in the experimental design.
Two new species and a new record of Entolomatoid fungi (Entolomataceae, Agaricales) from Pakistan
Authors: KHALID ABDUL NASIR , RAZZAQ FAUZIA , NASEER AROOJ , QASIM TAYYABA , KANWAL SOBIA
Published: September 2024

Taxonomic investigations on the family Entolomataceae were conducted in Pakistan from 2018 to 2022. Morphological characteristics and molecular phylogenetic analyses using ITS and LSU sequences revealed two new species, Entoloma pakistanicum and Rhodophana margallensis, and a new record, E. albotomentosum. Rhodophana margallensis is the first report of the genus Rhodophana from Pakistan. We present illustrated descriptions of the three species and comparison with morphologically similar or related species. Furthermore, we provide a key to the known species of Entoloma from Pakistan.
Two new synonyms of Lindenbergia philippensis (Orobanchaceae)
Authors: SINGH S.K. , PATIL SAMEER , BHATTACHARYYA SUBHASMIT , GHOSH POULAMI
Published: September 2024

N/A
Does economic globalization promote civil peace in developing countries?
Authors: Kollmeyer Christopher
Published: September 2024

This study questions the widely supported claim that economic globalization benefits developing countries by enhancing their prospects for civil peace. Drawing on ideas from across the social sciences, this study questions the nature of causation between economic globalization and civil peace and how it should be conceptualized and modeled. Instead of assuming a straightforward and static relationship whereby economic globalization directly increases the likelihood of civil peace, a range of alternative hypotheses are considered, including those about reverse and reciprocal causation and about dynamic and path-dependent effects. Using dynamic panel regression and vector autoregression, the study empirically examines how trade openness and foreign direct investment affect civil violence in a sample of all countries classified by the United Nations as developing. The results find positive links between economic globalization and civil peace, as much of the literature predicts, but show that this relationship mainly arises from complex patterns of causation rather than from the pacifying effects of economic globalization. These results are robust to various model specifications and sampling strategies. The study ends by considering whether economic globalization may indirectly promote civil peace by fostering long-term economic development.
Remixing The center: Missional frameworks from young adult lenses via Hip Hop culture
Authors: Radcliff Dwight A.
Published: September 2024

This article contends that mission practice can learn from Hip Hop culture. The article looks to Hip Hop culture to glean tools and frameworks for missionally engaging youth and young adults. Specifically, the article describes the processes of sampling, mixing, and poiesis and, then, offers missional applications. There is an explicit invitation for youth and young adults to be involved in sampling and mixing the missional and missiological classics in order to engage in a poiesis. In providing this application there is also the positing of understanding our current societal conditions under the heading of pericolonial, as opposed to postcolonial. The term pericolonial is not offered as it is used in archaeology and anthropology. Rather the state of perimenopause is centered, as one of the foci of the article is also how mission can make space for women and marginalized voices.
From critical theory to critical therapy: Towards a permanent psycho-political revolution between subjective and objective disalienation
Authors: Dyson Emily M
Published: September 2024

Critical theory has historically assumed an undialectical either/or between reformist therapy and revolutionary politics. Frantz Fanon’s dialectical, psycho-social approach to recovery as disalienation offers us a way out. Lying at the intersection of critical theory, political strategy and the history of political thought, this article highlights a lesser-known French tradition of Freudo-Marxist psycho-politics contemporaneous with the first generation of the Frankfurt School, but which placed therapeutic imperatives front and centre of its psycho-political praxis. This article uses Fanonian institutional psychotherapy to contest the anti-psychiatric conceit that madness is liberating and that therapy obstructs freedom. Fanon’s critical therapy speaks to the recent care-ethical turn of the contemporary organized left, whilst maintaining a structural critique of the aetiology and treatment of mental illness. This article concludes that recovery involves a permanent psycho-political revolution between the subjective and objective, which requires a radical transformation of both mental healthcare and the pathogenic social world to and within which it responds.
The association between milk and dairy products intake and insomnia symptoms among Japanese adults in community-based cohort
Authors: Sato Yuki , Yokokawa Hirohide , Suzuki Reiko , Goto Tomoko , Naito Toshio
Published: September 2024

Objective: To examine the association between habitual intake of milk and dairy products and insomnia. Design: Cross-sectional study by using cohort study data among 60,633 participants (22,721 men and 37,912 women) aged 20–74 years in eastern Japan. The data of milk and dairy products intake, sleep status and other lifestyle habits were collected by self-administered questionnaires. The question about milk and dairy products included whole milk, low-fat milk, cheese, yogurt, and lactic acid bacteria beverages, and were assessed by frequency (< 1 time/week, 1–2 times/week, 3–6 times/ week, and ≥ 1 time/day). Sleep status was scored with the Athens Insomnia Scale. Results: Logistic regression analysis showed that adjusted odds ratio (OR) and 95% confidence interval (95% CI) for insomnia were statistically significantly lower for whole milk intake > 1 time/day compared to < 1 time/week in all (OR: 0.91; 95% CI: 0.86–0.96; P = 0.001). The similar results were shown for women (OR: 0.90; 95% CI: 0.85–0.97; P = 0.002), not for men. In contrast, the adjusted odds for insomnia were high in the group that had frequencies of 3–6 times/week of lactic acid bacteria beverages compared to <1 time/week (OR: 1.20, 95% CI: 1.11–1.29; P < 0.001 in all; OR: 1.36; 95% CI: 1.19–1.55; P < 0.001 in men; OR: 1.13; 95% CI: 1.03–1.24; P = 0.009 in women). Conclusions: This cross-sectional study of Japanese populations showed a tendency for no insomniacs to consume whole milk more frequently.
Providing Emotional Support During the Process of Multiple Sclerosis Diagnosis (PrEliMS): A Feasibility Randomised Controlled Trial
Authors: das Nair Roshan , Mhizha-Murira Jacqueline R , Topcu Gogem , Tindall Tierney , Bale Clare , Moghaddam Nima , Scheffler-Ansari Grit , Drummond Avril , Fitzsimmons Deborah , Evangelou Nikos
Published: September 2024

Objectives

To evaluate the feasibility and acceptability of an emotional support programme for newly diagnosed people with multiple sclerosis.

Design

Three-arm, mixed methods, randomised controlled trial comparing usual care, versus usual care plus nurse-specialist support, versus usual care plus nurse-specialist support plus peer support.

Participants

Community-dwelling adults within two years of diagnosis or undergoing diagnosis.

Interventions

PrEliMS involves information provision, emotional support, and strategies and techniques based on psychoeducation, Acceptance and Commitment Therapy principles, supportive listening. One version of the intervention was provided by nurse-specialists alone and the other was provided by nurse-specialists plus peer support.

Main measures

The main outcome of interest was the feasibility of proceeding to a definitive trial, exploring recruitment rate, acceptability, completion of outcome measures (perceived stress, mood, self-efficacy, psychological impact, and service use), and signal of efficacy.

Results

Of 40 participants randomised (mean age 36.2 years (SD = 14.8); 54% women; 85% with relapsing-remitting MS), 36 and 38 returned 3- and 6-month questionnaires, respectively. Participant interviews suggested the trial was largely feasible, and the intervention acceptable, with some amendments to trial procedures and intervention delivery noted. There were, however, no statistically significant differences between groups at followup for any measures, and effect-size estimates were small.

Conclusion

A definitive trial combining nurse-specialist and peer support adjustment to diagnosis intervention is warranted, but more work exploring the delivery and fidelity of the intervention is needed before this is pursued