bluuebunny/crossref_metadata_2025 huggingface dataset:
Enterocyte-specific deletion of metal transporter Zip14 (Slc39a14) alters intestinal homeostasis through epigenetic mechanisms
Authors: Jimenez-Rondan Felix R. , Ruggiero Courtney H. , McKinley Kelley Lobean , Koh Jin , Roberts John F. , Triplett Eric W. , Cousins Robert J.
Published: December 2022

We show that enterocyte-specific ablation of zinc transporter Zip14 (Slc39a14) results in selective dysbiosis and differential expression of tight junction proteins, claudin 1 and 2, and specific cytokines associated with intestinal inflammation. HDAC activity and zinc uptake are reduced with Zip14 ablation. Using intestinal organoids, the expression defects of claudin 1 and 2 are resolved through zinc supplementation. These novel results suggest that zinc, an essential micronutrient, influences gene expression through epigenetic mechanisms.
Risk Factors Affecting Muscle Mass Decline in Maintenance Hemodialysis Patients
Authors: Song Yiqi , Zhang Qian , Ni Li , Zhang Minmin , Wang Mengjing , Zhang Weichen , Chen Jing
Published: December 2022

Objective. There is a high prevalence of sarcopenia in maintenance hemodialysis (MHD) patients, which is known to be associated with increased mortality. This study is aimed at analyzing the risk factors affecting muscle mass decline in MHD patients. Methods. This retrospective study included MHD patients who underwent two body composition assessments in October 2013 and November 2017. Depending on whether there was muscle loss or not, the patients were divided into a normal muscle mass (NMM) group and a muscle mass decline (MMD) group. According to the muscle mass decline rate, patients in the MMD group were further classified into a low‐rate group and a high‐rate group. Biochemical variables, serum vitamin concentrations, anthropometric data, SGA, muscle mass, handgrip, and daily steps were assessed. Risk factors for muscle mass decline were screened by multivariate logistic analysis and linear regression analysis. Results. Of the 72 MHD patients included in this study, 33 were male and 39 were female with a mean age of 56.80 ± 10.86 years and a mean dialysis duration of 7.50 ± 5.20 years. Age (P = .014) and serum 25(OH)D (P = .040) were found to be associated with a higher risk of muscle mass decline after adjusting for gender, dialysis vintage, albumin, and hs‐CRP (P = .040). Further analysis found that dialysis vintage (β = 0.285, P = .030), 25(OH)D (β = −0.351, P = .007), and log NT‐proBNP (β = 0.312, P = .020) were risk factors associated with the muscle mass decline rate in MHD patients. Conclusion. Age and serum 25(OH)D were associated with a higher risk of muscle mass decline, while 25(OH)D, dialysis vintage, and NT‐proBNP were associated with the muscle mass decline rate in MHD patients.
The Primary Alteration of Ventricular Myocardium Conduction: The Significant Determinant of Left Bundle Branch Block Pattern
Authors: Bacharova Ljuba , de Luna Bayes
Published: December 2022

Intraventricular conduction disturbances (IVCD) are currently generally accepted as ECG diagnostic categories. They are characterized by defined QRS complex patterns that reflect the abnormalities in the intraventricular sequence of activation that can be caused by pathology in the His-Purkinje conduction system (HP) or ventricular myocardium. However, the current understanding of the IVCD’s underlying mechanism is mostly attributed to HP structural or functional alterations. The involvement of the working ventricular myocardium is only marginally mentioned or not considered. This opinion paper is focused on the alterations of the ventricular working myocardium leading to the most frequent IVCD pattern—the left bundle branch block pattern (LBBB). Recognizing the underlying mechanisms of the LBBB patterns and the involvement of the ventricular working myocardium is of utmost clinical importance, considering a patient’s prognosis and indication for cardiac resynchronization therapy.
Phenotypic Diversity within Ugandan Yam (Dioscorea species) Germplasm Collection
Authors: Adjei Emmanuel Amponsah , Esuma Williams , Alicai Titus , Bhattacharjee Ranjana , Dramadri Isaac Onziga , Agaba Rolland , Chamba Emmanuel Boache , Odong Thomas L.
Published: December 2022

A proper understanding of the diversity of the available germplasm is an initial step for the genetic improvement of a crop through breeding. However, there is limited information on the diversity of Uganda’s yam germplasm. The study sought to characterize the diversity of yam germplasm utilized for decades in Uganda together with germplasm recently introduced from West Africa using phenotypic traits. A germplasm collection of 291 genotypes was characterized using 28 phenotypic traits. Data were subjected to multivariate analysis using principal component analysis and cluster analysis. The traits assessed were informative and discriminating, with 62% of the total variation explained among the first six principal components. Results showed that the important phenotypic traits contributing to most of the variability among the genotypes were leaves, flowering, and tuber traits. Ugandan genotypes were identified with amorphous tuber shapes compared to West African genotypes. The study has shown that there is ample phenotypic variability within the major yam genotypes in Uganda yam germplasm that can be used for genetic improvement. More in-depth molecular and biochemical studies to further understand the diversity are recommended. The preprint was made available by research square in the following link: “https://www.researchsquare.com/article/rs-1518551/v1.”
Risk Score for Prediction of Acute Kidney Injury in Patients with Acute ST-Segment Elevation Myocardial Infarction
Authors: Zhao Hui , Miao Runran , Lin Fei , Zhao Guoan
Published: December 2022

Background. Acute kidney injury (AKI) is an important comorbidity of ST-Segment Elevation Myocardial Infarction (STEMI) and worsens the prognosis. The purpose of this study was to investigate the relationship between clinical data, test results, surgical findings, and AKI in STEMI patients and to develop a simple, practical model for predicting the risk of AKI. Method. Prognostic prediction research with clinical risk score development was conducted. The data used for model development was derived from the database of the Henan Province Cardiovascular Disease Clinical Data and Sample Resource Bank Engineering Research Center. The data used for external validation was derived from the China Chest Pain Center database. The study endpoint was defined as the occurrence of AKI. Logistic regression analysis was used to identify independent predictors of AKI. Logistic coefficients of each predictor were used for score weighting and transformation. The predictive performance of the newly derived risk scores was validated, respectively, by receiver operating characteristic (ROC) regression in the development population and the external validation population. Result. A total of 364 patients, 57 (15.6%) with AKI and 307 (84.4%) without AKI, were included for score derivation. The validation crowd includes 88 STEMI patients in different institutions. A total of 11 potential predictors were explored under the multivariable logistic regression model. The new risk score was based on five final predictors which were

age
>
72
 
years

, ejection fraction of no more than 40%,

baseline
 
serum
 
creatinine
>
102.7
 
mmol
/
L

,

red
 
blood
 
cell
 
distribution
 
width
>
13.15
,

and culprit lesion located in the middistal segment. With only five predictor variables, the score predicted the risk of AKI with the effective discriminative ability (area under the receiver operating characteristic curve (AuROC): 0.721, 95% confidence interval (CI): 0.652-0.790). In the external validation, the newly developed score confirmed a similar discrimination as the crowd used for derivation (AuROC: 0.731, 95% CI: 0.624-0.838). Conclusion. The newly developed score was proved to have good predictive performance and could be practically applied for risk stratification of AKI in STEMI patients.
Effect of Iron Oxide on Self-Healing and Thermal Characteristics of Asphalt Based on Molecular Dynamics Simulation Perspective
Authors: Li Mingxia , Li Songjian , Zhu Cunzhen , Li Ning , Wang Haipeng
Published: December 2022

To compare the effects of two powders, iron oxide and mineral, on the healing process of asphalt molecules, Fe2O3-asphalt and SiO2-asphalt were constructed by Material Studio software (MS). The mean square displacement, diffusion coefficient, concentration distribution of the asphalt layer, and the thermal conductivity of the two models were analyzed to evaluate the influence of two powders on the diffusion behavior of asphalt molecules on a microlevel. The results show that the effect of Fe2O3 on the diffusion rate of asphalt molecules is greater than that of SiO2 at high temperature, but the effects are similar at low temperature. The diffusion coefficient of the Fe2O3-asphalt model increases faster than that of the SiO2-asphalt model with increasing temperature. Compared with SiO2, Fe2O3 is more conducive to the model’s reaching a state of uniform concentration, which is manifested as the rapid repair of cracks on a macrolevel. The thermal conductivity of the Fe2O3-asphalt model is higher than that of the SiO2-asphalt model.
Mechanical Test on Aluminum Alloy with Maximal Soluble SiC Reinforcement
Authors: Pruthviraju G. , Dambhare Sunil G. , Pathri Bhargav Prajwal , Ramakrishna M. , Gokulanathan L. , Balamurugan K. , Shumet W.
Published: December 2022

This work deals with the characteristics of LM-13alloy under cyclic stress with and without 63% by weight of SiC-reinforced composite particle reinforcements both cast and tempered at ambient condition. The hardness of the composite sample before and after tempering was 112 HV and 134HV. The tempered sample shows 16.4% increment. UTS of base alloy and the composite was determined to be 165 MPa and 149 and 210, and 145 and 192, respectively. The UTS decreases by 12% in cast state and 8% in tempered condition. The tempered base alloy shows an increment of 21%, and the 0.25% proof stress increased by 28%. After heat treatment, the elongation at the break of the base alloy improved to 3.5%. The tempered specimen shows an increased fatigue performance of approximately 43%. The fatigue life was determined to be about 165 repetitions at the 75 MPa level of stress with 75% of UTS utilization. Decohesion of a silicon particulate interaction and in certain circumstances, the subsequent breakdown of SiC particles has led to fractures in composites. The preheated eutectic silicon that had an almost gain round shape will withstand crack growth development, as the aluminum matrix had a higher cohesive force compared to reinforced SiC particles which provide less strain increase locations. Stronger bonds among silica eutectic and aluminum matrices produced the fracture across their contact, silicon breaks owing to the application of the fatigue load and lead to specimen failure.
Acrylamide and Glycidamide Hemoglobin Adduct Levels and Breast Cancer Risk in Japanese Women: A Nested Case–Control Study in the JPHC
Authors: Narii Nobuhiro , Kito Kumiko , Sobue Tomotaka , Zha Ling , Kitamura Tetsuhisa , Matsui Yasuto , Matsuda Tomonari , Kotemori Ayaka , Nakadate Misako , Iwasaki Motoki , Inoue Manami , Yamaji Taiki , Tsugane Shoichiro , Ishihara Junko , Sawada Norie
Published: December 2022

Background:

Acrylamide (AA) is classified as “probably carcinogenic to humans (class 2A)” by the International Agency for Research on Cancer. AA causes cancer owing to its mutagenic and genotoxic metabolite, glycidamide (GA), and its effects on sex hormones. Both AA and GA can interact with hemoglobin to hemoglobin adducts (HbAA and HbGA, respectively), which are considered appropriate biomarkers of internal exposure of AA. However, few epidemiologic studies reported an association of HbAA and HbGA with breast cancer.

Methods:

We conducted a nested case–control study within the Japan Public Health Center–based Prospective Study cohort (125 cases and 250 controls). Cases and controls were categorized into tertiles (lowest, middle, and highest) using the distribution of HbAA or HbGA levels in the control group and estimated ORs and 95% confidence intervals (CI) using conditional logistic regression, adjusting for potential confounders.

Results:

No association was observed between HbAA (ORHighestvs.Lowest, 1.34; 95% CI, 0.69–2.59), HbGA (ORHighest vs. Lowest, 1.46; 95% CI, 0.79–2.69), their sum HbAA+HbGA (ORHighest vs. Lowest, 1.36; 95% CI, 0.72–2.58) and breast cancer; however, some evidence of positive association was observed between their ratio, HbGA/HbAA, and breast cancer (ORHighest vs. Lowest, 2.19; 95% CI, 1.11–4.31).

Conclusions:

There was no association between biomarkers of AA and breast cancer.

Impact:

It is unlikely that AA increases breast cancer risk; however, the association of AA with breast cancer may need to be evaluated, with a focus not only on the absolute amount of HbAA or HbGA but also on HbGA/HbAA and the activity of metabolic genes.
Association of Torquetenovirus Viremia with Physical Frailty and Cognitive Impairment in Three Independent European Cohorts
Authors: Giacconi Robertina , Laffon Blanca , Costa Solange , Teixeira-Gomes Armanda , Maggi Fabrizio , Macera Lisa , Spezia Pietro Giorgio , Piacenza Francesco , Bürkle Alexander , Moreno-Villanueva María , Bonassi Stefano , Valdiglesias Vanessa , Teixeira Joao Paulo , Dollé Martijn E.T. , Rietman M. Liset , Jansen Eugène , Grune Tilman , Gonos Efstathios S. , Franceschi Claudio , Capri Miriam , Weinberger Birgit , Sikora Ewa , Stuetz Wolfgang , Toussaint Olivier , Debacq-Chainiaux Florence , Hervonen Antti , Hurme Mikko , Slagboom P. Eline , Schön Christiane , Bernhardt Jürgen , Breusing Nicolle , Pásaro Eduardo , Maseda Ana , Lorenzo-López Laura , Millán-Calenti José Carlos , Provinciali Mauro , Malavolta Marco
Published: December 2022

Introduction: Immunosenescence and inflammaging have been implicated in the pathophysiology of frailty. Torquetenovirus (TTV), a single-stranded DNA anellovirus, the major component of the human blood virome, shows an increased replication rate with advancing age. An elevated TTV viremia has been associated with an impaired immune function and an increased risk of mortality in the older population. The objective of this study was to analyze the relation between TTV viremia, physical frailty, and cognitive impairment. Methods: TTV viremia was measured in 1,131 nonfrail, 45 physically frail, and 113 cognitively impaired older adults recruited in the MARK-AGE study (overall mean age 64.7 ± 5.9 years), and then the results were checked in two other independent cohorts from Spain and Portugal, including 126 frail, 252 prefrail, and 141 nonfrail individuals (overall mean age: 77.5 ± 8.3 years). Results: TTV viremia ≥4log was associated with physical frailty (OR: 4.69; 95% CI: 2.06–10.67, p < 0.0001) and cognitive impairment (OR: 3.49, 95% CI: 2.14–5.69, p < 0.0001) in the MARK-AGE population. The association between TTV DNA load and frailty status was confirmed in the Spanish cohort, while a slight association with cognitive impairment was observed (OR: 1.33; 95% CI: 1.000–1.773), only in the unadjusted model. No association between TTV load and frailty or cognitive impairment was found in the Portuguese sample, although a negative association between TTV viremia and MMSE score was observed in Spanish and Portuguese females. Conclusions: These findings demonstrate an association between TTV viremia and physical frailty, while the association with cognitive impairment was observed only in the younger population from the MARK-AGE study. Further research is necessary to clarify TTV’s clinical relevance in the onset and progression of frailty and cognitive decline in older individuals.
Why Oncologists Should Feel Directly Involved in Persuading Patients with Head and Neck Cancer to Quit Smoking
Authors: Merlano Marco Carlo , Denaro Nerina , Galizia Danilo , Abbona Andrea , Paccagnella Matteo , Minei Silvia , Garrone Ornella , Bossi Paolo
Published: December 2022

Introduction: Among the risk factors for squamous cell carcinoma of the head and neck, smoking is still the most important today. Several studies agree on the effect of smoking on tumor microenvironment, while the definition of former smokers and the time of smoking cessation on biologic effect differs among papers. Methods: We conducted a narrative review on smoking effects in HNSCC. Results: There is evidence that smoker patients have a poorer prognosis than never smokers and former smokers. Translational studies show a relationship between smoking status and gene expression and support the importance of smoking cessation, for instance, demonstrating an inverse relationship between tumor-infiltrating lymphocytes and smoking. Conclusion: Convincing data suggest that quitting smoking at any time may improve patient outcomes. We advocate smoking cessation also after cancer diagnosis.
Current Trends in the Management of Helicobacter pylori Infection in Serbia: Preliminary Results from the European Registry on H. pylori Management
Authors: Milivojevic Vladimir , Babic Ivana , Kekic Dusan , Rankovic Ivan , Sagdati Sabir , Panic Nikola , Spasic Izabela Sekulic , Krstic Miodrag , Milosavljevic Tomica , Moreira Leticia , Nyssen Olga Perez , Mégraud Francis , O’ Morain Colm , Gisbert Javier
Published: December 2022

Background: Helicobacter pylori (H. pylori) is the most common chronic bacterial infection. Treatment effectiveness remains a subject of debate considering bacterial antimicrobial resistance. Our aim was to analyze the diagnostic methods and eradication treatments for H. pylori infection in Serbia. Methods: An observational multicenter prospective study was conducted in Serbia, as part of the European Registry on H. pylori Management (Hp-EuReg). Demographics, treatment indication, diagnostic methods, previous eradication attempts, and treatment were collected at AEG-REDCap e-CRF. Modified intention-to-treat (mITT) and per-protocol (PP) effectiveness analyses were performed. Safety, compliance, and bacterial antimicrobial resistance rates were reported. Data were quality checked. Results: Overall, 283 patients were included, with a mean age of 55 ± 15 years. Dyspepsia (n = 214, 77%) was the most frequent treatment indication, and histology (n = 144, 51%) was the most used diagnostic method. Overall eradication rate was 95% (PP) and 94% (mITT). Most prevalent first-line therapy was quadruple PPI + clarithromycin + amoxicillin + metronidazole, with a 96% effectiveness (p < 0.001). Second-line main treatment choice was triple amoxicillin + levofloxacin, with a 95% effectiveness (p < 0.05). Single-capsule Pylera® was the most prescribed third-line therapy, with 100% effectiveness (p < 0.05). Longer treatment duration was associated with a higher eradication rate in first-line therapy (p < 0.05). Clarithromycin and quinolone resistance rates in first-line were 24% and 8.3%, respectively. The overall adverse events’ incidence rate was 13.4%, and therapy compliance was 97%. Conclusions: Considering the high eradication rate, 14-day non-bismuth quadruple concomitant therapy is a reasonable first-line choice, while quinolone-based therapy and single-capsule Pylera® should be considered as rescue therapy options.
Improve the performance of automatic voltage regulator for power system using self-tuning fuzzy-PID controller
Authors: Saeed Majeed Wafaa , Ibrahem Nasser Amal , Rasheed Hameed Kassim
Published: December 2022

The optimal design of the automatic voltage regulators for a synchronous machine are positively reflected on the quality of voltage stability. This paper is concerned with the design of an AVR by adopting three control techniques. The first one was designed according to the traditional proportional integration-derived (PID) controller while the fuzzy logic was adopted in design the second powerful controller, finally the fuzzy PID controller for an automatic voltage regulator (AVR) based on fuzzy logic technology, selftuning fuzzy proportional integration-derived (STFPID) have been designed to tuning the gains of the PID controller (KP, KI and KD). To confirm the efficiency of the proposed control systems, a simulation was carried out, and the results showed that the designed STFPID controller achieves the best performance of the AVR system, and gives the preferable tracking low rise time, lower overshoot, least stetting time, minimal steady state error, and gives the ideal response against PID and fuzzy logic technology.
Embedded electronic system for evaluation of photovoltaic modules based on a current-voltage curve tracer
Authors: Yauri Ricardo , Espino Rafael
Published: December 2022

The rapid growth of the market for the use of renewable energy has increased the use of solar energy which has a significant role in power generation. This requires the insertion of equipment capable of providing precise measurements of the photovoltaic modules, either to verify the operation of the installation or to find specific problems. In this scenario, the current versus voltage curve tracer is used to describe the electrical behavior of the photovoltaic system through all the operating possibilities, but it has an excessive cost for small installations. This paper presents the development of a current-voltage curve tracer, capable of performing current, voltage and power measurements, contributing to the creation of equipment to test photovoltaic installations. The methods to obtain the I-V curves are presented and the characteristics of the embedded electronic system, which is based on an electronic load, are defined. As results, the simulations carried out for the variable load control, acquisition circuits and the implemented system are shown. In addition, the operation of the human-machine interface and the comparison with a commercial equipment are shown for reference.
Druken alcohol intelligent detection system IoT based Arduino controller
Authors: Aminah Nordin Siti , Mohd Yussof Zakiah , Nadia Mohammad Nurul
Published: December 2022

An intelligent alcohol detection system has been created to recognize the location of drunken drivers to prevent such road incidents. The project is being enhanced to use the internet of things (IoT) to make it easier for users to track their location and receive messages through their smartphones. The alcohol breath analyzer sensor detects the amount of alcohol in the driver's breath and the liquid crystal display (LCD) will display "Alcohol Detected" and the blood alcohol concentration (BAC) value if the level exceeds the threshold. İn addition, the global system for mobile (GSM) will send short message service (SMS) or make phone calls and telegram will sends BAC value, while the GPS will broadcast the discovered alcohol's location. This project implicitly provides more benefits for current efforts in the development of accident prevention systems in the hopes of putting them into practice in the real world to improve road safety.
An evaluation of automated measurement of slice sensitivity profile of computed tomography image: field of view variations
Authors: Rizqi Widyanti Elvira , Anam Choirul , Hidayanto Eko , Naufal Ariij , Haekal Mohammad
Published: December 2022

This study aims to evaluate the automated measurement of slice sensitivity profile (SSP) on the American Association of Physicists in Medicine (AAPM) computed tomography (CT) performance phantom for variations of slice thickness and field of view (FOV). The AAPM CT performance phantom was scanned using a Philips MRC 880 CT Scanner for variations of slice thickness and FOV. The slice thickness values were 1, 3, and 5 mm. The FOV values were 240, 300, 340, 400, and 440 mm. The automated SSPs and their fullwidth at half maximums (FWHMs) were automatically measured from the middle stair object of the phantom. To validate the automated measurement results, the FWHM values of SSPs obtained were compared to those from manual measurements. The differences between FWHMs from automated measurements and set slice thicknesses are less than 0.3 mm, while the differences between FWHMs from automated and manual measurements are less than 0.2 mm. The results from automated measurements are closer to the set slice thickness than those from manual measurements. This automated SSP measurement provides high accuracy and precision for both the slice thickness and the FOV variations.
Optimization of retinal blood vessel segmentation based on Gabor filters and particle swarm optimization
Authors: Fauzi Ahmad , Evan Lubis Lukmanda
Published: December 2022

The structure of the retinal blood vessels can be obtained by segmenting the fundus images. A fundus image can be gained through color fundus photography or fluorescein angiography (FA). The fundus image produced by the camera can cause noise which can reduce the quality of the fundus image. To reduce the noise, this research uses the non-local means filter (NLMF). For texture analysis, the study uses Gabor filters due to the frequencies of this filter as the same as the human visual system. The segmenting process of the retinal blood vessel is performed using K-means optimized by particle swarm optimization (PSO). The accuracy of 0.9525, the precision of 0.8330, the sensitivity of 0.5817, and the specificity of 0.9880 are obtained using the proposed method.
Data storage architecture for e-government interoperability: Morocco case
Authors: Benaddi Hanane , Laaz Naziha , Bouhlal Anass , El Kettani Elyoussfi
Published: December 2022

Nowadays, the amount of data created by the government and public sector organizations is growing at an exponential rate. Data sharing and the interoperability of e-government systems pose technological challenges. The lack of technical interoperability prevents the successful exchange and sharing of information among public organizations. To meet this challenge, enhancing interconnection and communication between different public infrastructures is an essential condition. To optimize the provisioning of storage resources, software defined storage (SDS) solutions add flexibility and adaptability to the storage process by isolating the hardware from the software. Hyper-converged infrastructure (HCI) is an emerging set of SDS solutions that provide compute, network and storage in a single platform. This paper presents a storage HCI-based architecture to store public data from different public entities, enhance collaboration and improve technical interoperability. The relevance of this approach of e-government interoperability is to allow public organization to store their data in an efficient and flexible manner on one hand, and to participate to Morocco’s e-government project on the other hand.
Hybrid agile development phases: the practice in software projects as performed by software engineering team
Authors: Yahya Norzariyah , Sarah Maidin Siti
Published: December 2022

The combination of scrum and waterfall is one of the software engineering teams that preferred hybrid agile models. The purpose of combining the two models is to leverage the advantages of each also to tailor the hybrid agile model to the needs of the project. However, to what extent are the phases, stages, and features of scrum and waterfall implemented in a software project remains unclear. Additionally, which phase will employ scrum, and when will waterfall be deemed optimal is also the arising question. This research adopted a qualitative study, and interviews are used as a data collection instrument. The interview is conducted based on an interview protocol, and thematic analysis is utilized to extract the themes from the interviews. This study investigates how the scrum and waterfall models are utilized in a software project, and three themes were identified in answering the research question. The findings indicate five development phases in a hybrid agile project and that waterfall is the preferable model in planning, while development is on scrum, and project testing and deployment could be either waterfall or scrum.
Prediction of movie success based on machine learning and twitter sentiment analysis using internet movie database data
Authors: Tripathi Jyoti , Tiwari Sunita , Saini Anu , Kumari Sunita
Published: December 2022

Nowadays, predicting the success of a new movie is a crucial task. In this work, the hybrid approach considers the movie features as well as sentiment expressed in the movie review to predict the success rate of a movie. Multiple movie features such as title, director, star cast, and writer. Are considered for prediction. The related raw data is collected from the internet movie database (IMDb) website and after pre-processing, the collected data is used to generate the supervised machine learning model. Different supervised learning models are compared and the one with the best results is used further. The mean squared error, root mean squared error and r2 score of the models generated are comparable with existing models. Further, sentiment analysis of the movie-related tweets is performed. The accuracy of best sentiment analysis model is 88.47%. Finally, the two models are combined to give the success prediction rating of new movies and the results of the hybrid model are encouraging. The proposed model may be used to find the top-rated movies of a particular calendar year.
GoMap: Combining step counting technique with augmented reality for a mobile-based indoor map locator
Authors: Atikah Sharin Nursyahirah , Mohd Norowi Noris , Nurliyana Abdullah Lili , Seng-Beng Ng
Published: December 2022

In recent years, indoor navigation and localization has become a popular alternative to paper-based maps. However, the most popular navigation approach of using the global positioning satellite (GPS) does not work well indoors and the majority of current approaches designed for indoor navigation does not provide realistic solutions to key challenges, including implementation cost, accuracy, longer computation processes, and practicality. The step count method was proposed to solve these issues. This paper introduces GoMap - a mobile-based indoor locator map application, which combines the step counting technique and augmented reality (AR). The design and architecture of GoMap is described in this paper. Two small-scale studies were conducted to demonstrate the performance of GoMap. The first study found that GoMap’s performance and accuracy was comparable to other step counting app such as “Google Fit”. The second part of the study demonstrated the feasibility of the application when used in a real-world setting. The findings from the studies show that GoMap is a promising application that can help the indoor navigation process.
António Hespanha e as vésperas das humanidades digitais
Authors: Camarinhas Nuno
Published: December 2022

Ao longo do seu percurso como historiador, António Hespanha cultivou a inovação metodológica, colocada sempre a serviço de um enorme rigor com a escolha e a exploração das fontes. Parte muito relevante do pioneirismo do seu trabalho está ligada à permanente abertura ao que as tecnologias da informação e as ferramentas digitais poderiam trazer à historiografia, não apenas enquanto utensílios de trabalho analítico mas também como potentes instrumentos de divulgação e disponibilização, em larga escala, de dados e de trabalho crítico. Este texto, fazendo um breve conspecto do trabalho de António Hespanha com forte investimento nos meios tecnológicos, procura demonstrar o seu papel pioneiro na aplicação e divulgação do que hoje conhecemos como humanidades digitais.
Fazer e desfazer história: a contribuição historiográfica de António Manuel Hespanha
Authors: Dantas Monica Duarte , Barbosa Samuel
Published: December 2022

Este dossiê discute as contribuições de António Manuel Hespanha (1945-2019) para a história política e a história do direito, bem como o seu pioneirismo no campo das humanidades digitais.
Os usos do direito na América ultramarina portuguesa: entre o pragmatismo dos rústicos e a argumentação refinada dos letrados
Authors: Alveal Carmen , Fonseca Marcos Arthur Viana da
Published: December 2022

Este texto se propõe a dialogar com a obra do jurista António M. Hespanha, mais especificamente com o artigo “Porque é que existe e em que é que consiste um direito colonial brasileiro” e o livro Como os juristas viam o mundo. A partir de suas contribuições em torno do direito, pretende-se debater a existência de um direito local e o seu uso por instâncias locais em contraposição à concepção de um direito erudito, letrado, utilizado pelos oficiais régios. No período moderno, convivia-se com uma miríade de direitos: direito romano, canônico, comum (ius commune), régio, local e costumeiro. A primeira parte deste texto analisa processos judiciais referentes a questões fundiárias oriundas da Comarca de Paranaguá. A segunda foca alguns casos nos quais os oficiais também utilizaram as diferentes ordens normativas coexistentes em proveito próprio tendo como foco as Capitanias do Norte do Estado do Brasil. O objetivo é perceber o uso local do direito, aproximando-se do que o professor Hespanha afirmava, da existência de um direito “brasileiro” no período colonial.
Prospective Association of Daily Steps With Cardiovascular Disease: A Harmonized Meta-Analysis
Authors: Paluch Amanda E. , Bajpai Shivangi , Ballin Marcel , Bassett David R. , Buford Thomas W. , Carnethon Mercedes R. , Chernofsky Ariel , Dooley Erin E. , Ekelund Ulf , Evenson Kelly R. , Galuska Deborah A. , Jefferis Barbara J. , Kong Lingsong , Kraus William E. , Larson Martin G. , Lee I-Min , Matthews Charles E. , Newton Robert L. , Nordström Anna , Nordström Peter , Palta Priya , Patel Alpa V. , Pettee Gabriel Kelley , Pieper Carl F. , Pompeii Lisa , Rees-Punia Erika , Spartano Nicole L. , Vasan Ramachandran S. , Whincup Peter H. , Yang Shengping , Fulton Janet E. ,   for the Steps for Health Collaborative
Published: December 2022

Background:

Taking fewer than the widely promoted “10 000 steps per day” has recently been associated with lower risk of all-cause mortality. The relationship of steps and cardiovascular disease (CVD) risk remains poorly described. A meta-analysis examining the dose–response relationship between steps per day and CVD can help inform clinical and public health guidelines.

Methods:

Eight prospective studies (20 152 adults [ie, ≥18 years of age]) were included with device-measured steps and participants followed for CVD events. Studies quantified steps per day and CVD events were defined as fatal and nonfatal coronary heart disease, stroke, and heart failure. Cox proportional hazards regression analyses were completed using study-specific quartiles and hazard ratios (HR) and 95% CI were meta-analyzed with inverse-variance–weighted random effects models.

Results:

The mean age of participants was 63.2±12.4 years and 52% were women. The mean follow-up was 6.2 years (123 209 person-years), with a total of 1523 CVD events (12.4 per 1000 participant-years) reported. There was a significant difference in the association of steps per day and CVD between older (ie, ≥60 years of age) and younger adults (ie, <60 years of age). For older adults, the HR for quartile 2 was 0.80 (95% CI, 0.69 to 0.93), 0.62 for quartile 3 (95% CI, 0.52 to 0.74), and 0.51 for quartile 4 (95% CI, 0.41 to 0.63) compared with the lowest quartile. For younger adults, the HR for quartile 2 was 0.79 (95% CI, 0.46 to 1.35), 0.90 for quartile 3 (95% CI, 0.64 to 1.25), and 0.95 for quartile 4 (95% CI, 0.61 to 1.48) compared with the lowest quartile. Restricted cubic splines demonstrated a nonlinear association whereby more steps were associated with decreased risk of CVD among older adults.

Conclusions:

For older adults, taking more daily steps was associated with a progressively decreased risk of CVD. Monitoring and promoting steps per day is a simple metric for clinician–patient communication and population health to reduce the risk of CVD.
Nomenclatural acts in zoological nomenclature
Authors: DUBOIS ALAIN
Published: December 2022

The present work proposes a precise formal definition and an expansion of the concept of ‘nomenclatural act’ which is present in the Code but not clearly delimitated from other related concepts, and provides a list of the published statements that correspond to this concept, a terminology for this and related acts, as well as for information affecting zoological nomenclature. These technical terms will be useful for unambiguous designation of the concepts of zoological nomenclature related to this concept, which are denoted in the Code by ‘common language’ terms having often widely different meanings. They will also be of great help for a future computerisation of the Rules of the Code, which will be possible only if distinct concepts are identified and pointed to by distinct terms. An important outcome of the present work is that genuine nomenclatural acts (onomatergies), as well as statements about nomenclatural status (cataphasy), acquire nomenclatural availability (i.e., existence) only if promulgated in paper or electronic publications complying with Article 8 of the Code, but cannot be made available online in electronic databases or other labile documents failing to comply with these Rules as revised in 2012.
Taxonomic revision of the genus Amaranthus (Amaranthaceae) in Saudi Arabia
Authors: HASSAN WALAA A. , AL-SHAYE NAJLA A. , ALGHAMDI SALMA , KORANY SHEREEN M. , IAMONICO DUILIO
Published: December 2022

A taxonomic revision of the genus Amaranthus (Amaranthaceae) in Saudi Arabia, based on both field surveys and examination of harbarium specimens, is here presented. Collected exsiccata are kept the Herbaria PNUH and RO. An extensive literature was also analysed. Sixtheen non-hybrid taxa (twelve species) are recognized. Data about nomenclature (accepted names, main synonyms, and types), morphology, chromosome number, chorology (for native taxa) or alien status (for exotic taxa), occurrence in Saudi Arabia, ecology (preferential habitat, phenology, elevation), and taxonomic annotations are provided for each taxon. A diagnostic key is proposed. Four taxa (A. graecizans subsp. graecizans, A. graecizans subsp. sylvestris, A. graecizans subsp. thellungianus, and A. sparganicephalus) are native, whereas the other ones are to be considered aliens. A. dubius and A. blitoides var. blitoides are new for the national flora. Furthermore, the name A. sparganicephalus is neotypified on a specimen deposited at E and a nomenclatural change (A. blitum var. nanus comb. nov.) is proposed.
One new species and one new record for the genus Mesogastrura (Collembola, Hypogastruridae) from Korean caves, with DNA barcodes
Authors: CHANG GYU-DONG , KIM SUN-SOOK , PARK KYUNG-HWA
Published: December 2022

We collected one new species and one new record in the genus Mesogastrura Bonet, 1930 (family Hypogastruridae) from three caves with different origins in the Korean Peninsula; Mesogastrura seotalensis sp. nov. and Mesogastrura ojcoviensis (Stach, 1919). The genus Mesogastrura Bonet, 1930 is newly recorded from the Korean Peninsula. Mesogastrura seotalensis sp. nov. shows various body color (light brown or much less and light purple), 3 + 3 eyes and unguis with three inner teeth. On the other hand, Mesogastrura ojcoviensis (Stach, 1919) is characterized by white body color, 2 + 2 eyes and unguis without inner tooth (rarely with 1). These species were found in piles of bat’s guano inside of caves, so they are considered as troglophilous and guanophilous species. Partial DNA sequences of mitochondrial cytochrome c oxidase subunit I (COI) gene were used as DNA barcodes to clarify the species delimitation.
The unexpected discovery of the Afrotropical genus Tricorythus Eaton, 1868 (Ephemeroptera: Tricorythidae) from the Oriental region with description of a new species
Authors: SRINIVASAN PANDIARAJAN , SIVARUBAN T. , BARATHY S. , ISACK RAJASEKARAN
Published: December 2022

Tricorythus meenakshi sp. n., is described based on all the stages from Tamil Nadu, Southern India. This new Indian species is most closely related to the Afrotropical species T. discolor Burmeister and T. tener Kluge. The new species can be separated from others in the genus by: In male imago, i) body dorsally with a colorless median stripe from head to abdomen; ii) femur and base of the tibia of all legs dark, rest mostly colorless; and iii) penis shape; and in the larva, i) body slender with a light median stripe as in adult; ii) protoptera dark in both sexes; iii) mouthparts details; iv) tarsal claws denticulation; and v) shape of denticles on hind margins of abdominal terga. Previously, the genus Tricorythus Eaton was known only from the Afrotropical realm; this is the first record of this genus from the Oriental realm.
A new species of Dicaelotus Wesmael (Hymenoptera, Ichneumonidae, Ichneumoninae) parasitizing Asclerobia sinensis (Lepidoptera) in seed pods of Caragana spp.
Authors: SHENG MAO-LING , YANG JIAN-JUN , GUO HUI-MEI , LI TAO
Published: December 2022

A new species of Ichneumoninae, Dicaelotus caraganae Sheng & Li, sp. nov.,is described and illustrated. Specimens were reared from the cocoon of Asclerobia sinensis (Caradja, 1937) (Lepidoptera, Pyralidae), from Hangjinqi, Inner Mongolia Autonomous Region, China. The new species is characterized by face very short, median length shorter than clypeus; clypeus 2.9 × as wide as long, apical margin with weak median convex; area basalis of propodeum very short, lateral carinae indistinct; hind coxa partly irregularly black; fourth and subsequent metasomal tergites black. A key to species of Dicaelotus known in China is provided.
Spatiotemporal Trends in Near-Natural New Zealand River Flow
Authors: Queen Laura E. , Dean Sam , Stone Dáithí , Henderson Roddy , Renwick James
Published: December 2022

Anthropogenic climate change is affecting rivers worldwide, threatening water availability and altering the risk of natural hazards. Understanding the pattern of regional streamflow trends can help to inform region-specific policies to mitigate and adapt to any negative impacts on society and the environment. We present a benchmark dataset of long, near-natural streamflow records across Aotearoa New Zealand (NZ) and the first nationwide analysis of observed spatiotemporal streamflow trends. Individual records rarely have significant trends, but when aggregated within homogenous hydrologic regions (determined through cluster analyses), significant regional trends emerge. A multitemporal approach that uses all available data for each region and considers trend significance over time reveals the influence of decadal variability in some seasons and regions, and consistent trends in others. Over the last 50+ years, winter streamflow has significantly increased in the west South Island and has significantly decreased in the north North Island; summer streamflow has significantly decreased for most of the North Island; autumn streamflow has generally dried nationwide; and spring streamflow has increased along the west coast and decreased along the east coast. Correlations between streamflow and dynamic and thermodynamic climate indices reveal the dominant drivers of hydrologic behavior across NZ. Consistencies between the observed near-natural streamflow trends and observed changes in circulation and thermodynamic processes suggest possible climate change impacts on NZ hydrology.
Surgical Treatment of the Five Most Common Types of Cancer in Brazil: 7 Years Analysis Overview
Authors: Oliveira Trindade Bruna , Brandao Gabriela R. , Reis de Oliveira Marina , Bueno Motter Sarah
Published: December 2022

Background

Surgery is the main treatment for the majority of solid cancers. Studies investigating surgical interventions are a critical asset in improving patient health outcomes. We aim to analyze the temporal and spatial distribution of the surgical treatment of Brazil’s 5 most common types of cancer.

Methods

The selected cancers were stomach, colorectal and rectosigmoid junction, bronchial and lung, breast, and prostatic. Surgical data were collected from the DATASUS database from 2013 to 2019. Statistical analyses included linear regression tests with a significance level of .05.

Results

From 2013 to 2019, 19.72% of the diagnoses of all cancers were treated surgically. Only breast cancer didn’t have a significant linear increase in surgeries ( P = .702). Prostatic cancer had the highest annual increase rate and breast the lowest. Analyzing the Brazilian regions, the Southeast had the highest incidence of oncological surgeries, and the Midwest had the lowest.

Discussion

Brazil’s surgical oncology scenario is progressing positively through the analyzed period. The analysis of the 5 most common types of cancer in Brazil and their progression over the years provides an idea of the cancer surgery capacity in Brazil. There were disparities between the Brazilian regions in all types of cancer. Our study is the first step to better comprehending cancer care in Brazil and the access issues that some areas have. With that, it will be possible to provide better care to cancer patients needing surgical treatment.
The War on Drugs has Unduly Biased Substance Use Research
Authors: Stone Bryant M.
Published: December 2022

After working in the substance use field for several years and conducting research on substance use, it has come to my attention how deeply ingrained the War on Drugs propaganda is in substance use research. The lines of research demonstrating the potential benefits of substance use (including illicit substances), delineation of harm from stigma, and the societal impact of the War on Drugs is rather weak and lacking, despite numerous recent studies showing the benefits of certain substances and reports of individuals in therapy and online suggesing that illicit substances help them in some respects. There are numerous critical implications of this bias in substance use research. Suppose the field primarily produces studies that show that all substances are harmful in almost any circumstance and that substance use disorders (SUDs) are primarily driven by psychological deficits (e.g., willpower). In that case, we, as researchers, would be feeding into the War on Drugs, which is known for marginalizing individuals, promoting organized crime, exacerbating SUDs, feeding into a police and prison state, and killing individuals due to tainted substances. Substance use researchers and clinicians are among the first to recognize that the War on Drugs has failed. Yet, despite this belief, we seem to have not quite fully noticed how the propaganda has influenced how we conduct our jobs and the research we produce. In the current letter, I inform researchers who study substance use and clinicians who treat SUDs to acknowledge their own learned biases against substances and those who use substances; to be more cautious when interpreting substance use data in the future.
When and How Tourists Engage in Citizenship Behavior: The Interactive Effect of Trait Gratitude and Positive Resident–Tourist Contact
Authors: Tu Hongwei , Zhang Zhihui , Jiang Ziming
Published: December 2022

This study investigates when and how trait gratitude stimulates tourist citizenship behavior (TCB). Building on trait activation theory, the present study proposes a mediated moderation model in which tourists’ trait gratitude and positive resident–tourist contact jointly influence TCB. In driving TCB, the interactive effect of trait gratitude and positive contact is mediated by perceived insider status. Data were collected from 497 Mount Wuyi tourists and analyzed using structural equation modeling. The results reveal that trait gratitude positively influences TCB, and this relationship is moderated by positive contact. Furthermore, positive contact moderates the association between trait gratitude and perceived insider status. Additionally, perceived insider status, which is positively related to TCB, significantly mediates the moderating effects of positive contact on the link between tourists’ trait gratitude and TCB.