bluuebunny/crossref_metadata_2025 huggingface dataset:
Microwave-assisted synthesis and in vitro antimycobacterial evaluation of some new N-benzylidene-1H-benzo[d]imidazol-6-amine derivatives
Authors: Almehmadi Mazen , Alsharif Abdualziz , Allahyani Mamdouh , Asif Mohammad
Published: October 2024

N-Benzylidene-1H-benzo[d]-imidazol-6-amines (2a-f) were synthesized by the reaction between 1H-benzo[d] imidazol-6-amine and substituted aromatic aldehydes in the presence of ethyl alcohol and glacial acetic acid using microwave irradiation technique. The structures of the compounds were determined using elemental analysis, infrared, 1HNMR, and MS spectrum data. The microplate alamar blue assay method was used to test the synthesized compounds for their in vitro antimycobacterial activity against strains of Mycobacterium tuberculosis H37RV strain. Among tested compounds, compound 2a with a minimal inhibitory concentration (MIC) value of 6.25 μg/mL and compound 2b with a MIC value of 3.125 μg/mL showed better antitubercular activity than pyrazinamide and streptomycin with a MIC value of 3.125 μg/mL and 6.25 μg/mL, respectively. The electron-withdrawing group (-Cl and -NO2) substituted derivatives exhibited better activity than the electron-donating group (-OH, -CH3, and -OCH3) substituted derivatives.. KEYWORDS :Benzimidazole, Schiff base, Microwave method, Antitubercular activity.
Microwave-assisted synthesis of some new 2-(substituted phenyl)-3-(thiazol-2-yl)imidazo[4,5-b]indoles of biological interest
Authors: Sharma Gyanendra Kumar , Singh Gurvinder Pal , Bhardwaj Harsh , Sharma Umesh Kumar , Singh Manish Pal , Bhardwaj Himanshu , Mishra Akhileshar Prasad
Published: October 2024

In the present investigation, we have synthesized some new 2-(substituted phenyl)-3-(thiazol-2-yl) imidazo[4,5-b]indoles (1b-8b) of biological interest. In the last step of the synthesis, N-(substituted benzylidene)thiazole-2- amines (1a-8a) were reacted with isatin and ammonium acetate using silica gel as the solid support to yield the corresponding substituted thiazolyl imidazo indole derivatives (1b-8b). The reactions were carried out by two different techniques - conventional and microwave irradiation. The microwave irradiation method offers excellent yield, lesser reaction time, and eco-environmental friendly reaction. All the synthesized compounds showed anticancer (Dalton lymphoma ascites cell line and EAC cell line method) and antibacterial activity (cup plate method).. KEYWORDS :Thiazolyl imidazo indole, Microwave-assisted synthesis, Anticancer, Antibacterial.
Comprehensive review on hybridization approach in anti-malarial research
Authors: Singh Priyanka , Narsinghani Tamanna
Published: October 2024

Malaria endures a major health problem worldwide. Over the past few decades, the issue posed by multidrug resistance has reached an alarming level in many countries. The use of most anti-malarial agents is limited not only by the rapid development of drug resistance but also by the measured pipeline of effective pharmaceuticals available against resistant strains. Hybrid molecules, which contain multiple pharmacophoric units covalently linked together through metabolically stable linkage (conjugate), fusion, and merging of two functionalities into single molecule have the prospects to conquer drug resistance, overcome toxicity, and enhancement of efficacy. This review attempted to shed light on the hybridization approach by compiling past to recent studies conducted by researchers on aminoquinoline antimalarial hybrids.. KEYWORDS :Antimalarial drugs, Chloroquine resistance, Plasmodium falciparum, 4-aminoquinolines, Hybrids.
High degree of regioselectivity during the synthesis of new allylcoumarins employing thermal Claisen rearrangement
Authors: Shit Ranjt Kumar , Sinha Nitai Chand
Published: October 2024

Allyloxycoumarins (3,4) and ethyl 2-allyloxycinnamates (27, 28) were converted into 7-hydroxy-8- allylcoumarins (5,6), 2-hydroxy-3-allyl-4-methoxy-E-cinnamate ester (29), and 2-hydroxy-3-acetyl-4-methoxy-5-allyl cinnamate ester (30) by thermal Claisen rearrangement. The compounds 7-hydroxy-8-allylcoumarins (5,6) and 2-hydroxy-3- allyl cinnamate (30) on acylation or benzoylation, followed by Fries rearrangement gave 6-acetyl-7-hydroxy-8-allylcoumarins (15-20), 6-benzoyl-7-hydroxy-8-allylcoumarins (21,22), and 2-hydroxy-3-allyl-4-methoxy-5-acetylcoumarin (31). The compounds (33) and (30) underwent cyclization using boron tribromide in dichloromethane solvent at 0 degree C temperature to give 6-acetyl-7-hydroxy-8-allylcoumarin (15 or 34), that is, starting compound and 6-allyl-7-hydroxy-8-acetyl coumarin (32).. KEYWORDS :Allyl cinnamate, Coumarin, Claisen rearrangement, Regioselectivity.
Introduction Of Carbon Into Sintered Steels By Combining Graphite And Fe-C Masteral-loys
Authors: Hojati Milad , Gierl-Mayer Christian , Danninger Herbert
Published: October 2024

Carbon is typically introduced into sintered steels through admixed fine graphite, the dissolution dur-ing sintering however being relatively slow. An alternative route would be the introduction via a car-bon-rich Fe-C powder containing carbon as cementite. In the present study it is shown that already addition of a minor proportion of carbon through atomized Fe-4.5%C masteralloy powder activates carbothermal reduction of the surface oxides, shifting the CO formation temperature to lower levels, as well as dissolution of graphite in the matrix. This is particularly noticeable in steels prepared from prealloyed steel powder Fe-3%Cr-0.5%Mo. The property most sensitive to carbon dissolution is the coercive force, which offers the chance to nondestructively characterize this important process.
Microstructural And Mechanical Characterization Of A Spark Plasma Sintered Al-Containing Refractory High-Entropy Alloy
Authors: Carlucci Giovanni , Ferrario Edoardo , Lupi Giorgia , Bianchi Andrea , Maranini Giulia , Coduri Mauro , Anselmi-Tamburini Umberto , Casati Riccardo
Published: October 2024

Over the past decade, refractory high-entropy alloys (RHEAs) have been intensively studied due to their excellent high-temperature performances. Significant effort has been dedicated to reducing their density, aiming to make them competitive with Ni-based superalloys. However, RHEAs are typically produced through casting methods, which, given the high melting temperatures of their constitutive elements, may lead to inhomogeneous and coarse microstructures, thereby compromising their mechanical properties. Given this context, powder metallurgy would be a preferable route for manufacturing high-performing RHEA components. In this study, spark plasma sintering was employed to produce the biocompatible MoNbTaTiZr RHEA, later modified with the addition of aluminum to reduce its density. The microstructure and the mechanical properties of both alloys were investigated. Eventually, a component with a gradient of aluminum was also manufactured by a diffusion couple, allowing a more in-depth investigation on the effect of aluminum content on the properties of the RHEA.
Elaboration Of ODS Austenitic Steel From High Energy Horizontal Attritor
Authors: Baret Paul , Boulnat Xavier , de Carlan Yann , Chaffron Laurent , Fabrègue Damien , Malaplate Joël
Published: October 2024

Austenitic steel was the reference cladding material in sodium cooled fast neutron nuclear reactors. These alloys exhibit good high temperature mechanical properties and they can withstand very high irradiation doses. To further increase the performance of these alloys, two distinct ways of improvement are possible: oxides dispersion strengthening or ultra fine grain microstructure. In order to achieve the desired enhanced material, powder metallurgy and in particular mechanical alloying route is promising. However, the high ductility of austenitic steel significantly reduces the powder production yield and worsens the supersaturation of oxides during mechanical alloying. To overcome this issue, multiple batches were produced using high-energy horizontal attritor at times ranging from 5 to 40 hours and consolidated by Spark Plasma Sintering (SPS). This paper tackles the characterization of powders after mechanical alloying and SPS compacts.
L-PBF Printing Of 7075 Aluminium Powder Modified Using A Pure Ti PVD Coating : In-Situ Micro-Alloying
Authors: Kairet Thomas , Godet Stéphane , Malet LoÏc , Hemberg Alex
Published: October 2024

The titanium coated powder has shown promising results for in-situ microalloying. Hot cracking of the 7075 alloy was completely inhibited and grain refinement is massive. This effect is visible with and without preheating of the build plate. Mapping of the alloying elements has shown that precipitation at the grain boundaries is important, hence these elements require solution treatment to be available for precipitation hardening. The best yield strength achieved in this work was 376MPa.
Enhancing Worm Gear Efficiency: Directed Energy Deposition of CuSn10 Alloy Onto Tooth Profiles
Authors: Raghavendra Sunil , Amirabdollahian Sasan , Perini Matteo , Chemello Marco , Benedetti Matteo
Published: October 2024

With the current development in additive manufacturing (AM) processes, such as Laser directed energy deposition (L-DED), efficient usage of raw materials is possible. With the aid of this L-DED process, we aim to develop an efficient way to reduce the use of bronze in worm gears. Our objective is to fabricate worm gears by applying CuSn10 (bronze) alloy onto a stainless steel tooth created through the L-PBF process. We assess the impact of laser power, feed rate, scanning speed, and scanning strategy on the deposition process. The deposited cross-sections undergo analysis for porosity, hardness, dilution, and microstructure at various locations along the tooth profile.
La vie au-delà de la vie: Droits de l’homme, espace politique et revendications de droits.
Authors: Saada Julie
Published: October 2024

Penser les droits humains dans une perspective foucaldienne, telle que celle qui est adoptée dans la présentation du colloque, soulève un paradoxe. Le texte de présentation rappelle en effet que pour Foucault, le pouvoir, compris comme pouvoir du souverain de donner la mort, a longtemps été opposé à la vie. C’est lorsque, par la suite, la vie et le pouvoir se sont articulés, que le pouvoir est devenu un pouvoir sur la vie sous la forme d’une biopolitique. La question des droits humains est posée à partir de ce renversement, notamment dans le contexte des dictatures latino-américaines et singulièrement brésilienne.
 
[1] Je parle des “droits de l’homme” lorsque je me réfère aux déclarations de la Révolution française et de “droits humains” pour les déclarations et conventions depuis 1948. Les droits de l’homme définissent essentiellement les relations entre les citoyens et les gouvernants, leur caractère genré peut être souligné (les femmes n’ayant pas à l’époque accès à l’ensemble des droits de la citoyenneté) ; les droits humains relèvent du droit international et incluent les femmes. En outre, sans ignorer les sources non-occidentales de ces droits, mon propos se centre, surtout dans la première partie, sur les sources européennes puisqu’il s’agit d’identifier la formation des idées qui ont rendu possible et pensable la Déclaration de 1789.
[2] Cette contribution est issue de ma communication au colloque « III Encontro Nacional de Biopolítica – A questão dos Direitos Humanos em questão » organisé par Marcos Nalli (université de Londrina, 27 novembre-1er décembre 2023). Je remercie Marcos Nalli pour son invitation au colloque et pour la possibilité de publier ma communication, ainsi que Lorena Balbino pour la traduction.
espetacularização da política a partir de Agamben e Debord: a construção do migrante e do refugiado como homini sacri e seus direitos humanos sob ameaça
Authors: Junges Marcia Rosane
Published: October 2024

Neste artigo analisamos como as categorias da glória e do espetáculo são fundamentais na construção dos migrantes e refugiados como homines sacri e a ameaça aos seus direitos humanos. Em primeiro lugar, nos ocupamos do conceito da glória, em Giorgio Agamben, lastreado na teologia política. A seguir, examinamos a categoria do espetáculo, em Guy Debord. Na sequência, discutimos em que aspectos esse cenário configura os alicerces da política do nosso tempo, dentro das democracias liberais de massas, auxiliando na instalação e manutenção do estado de exceção, delineando a ideia do migrante e do refugiado como vidas matáveis sem que se incorra em crime, fragilizando seus direitos humanos.
Michel Foucault: a vida e a humanidade como produções da biopolítica
Authors: Carmo Temple Giovana
Published: October 2024

Resumo: Neste artigo, parto da noção de “soberania sujeita” que Foucault analisa em uma entrevista de 1971 para refletir a produção, pelo direito romano, do discurso humanista e seus efeitos na atualidade. A partir da “soberania sujeita, problematizo o discurso humanista norteador da biopolítica, particularmente com relação à gestão da vida e da noção humanidade para, ao final, refletir as vidas esconjuradas pelo discurso humanista e secularmente silenciadas, violentadas e assassinadas por uma racionalidade política que produz e reforça a violência de gênero, de raça e de classe. Para tanto, retomo textos de Audre Lorde, Silvia Federici, Sueli Carneiro e Paul B. Preciado.
Palavras-chave: Soberania Sujeita. Biopolítica. Gênero. Raça. Classe
Ontotecnologias do corpo e biopolítica na era da pós-humanidade e da pós-emancipação
Authors: Cascais António Fernando
Published: October 2024

Fundamental para entendermos o horizonte generalizadamente “antropofágico” das relações interindividuais, de consumo indiscriminado de tudo e todos por todos, a ideia de “uso dos corpos” mostra ser crucial para a regulação humanista contra o abuso, a instrumentalização e a exploração. Por sua vez, o adquirido da tecnicidade originária, enquanto condição técnica do próprio anthropos, significa que nem corpo, nem linguagem escapam à disponibilidade de todas as coisas na direção indicada pela técnica. Surgindo doravante como grelha de inteligibilidade do mundo e do próprio homem, ela abre a uma teoria crítica pós-humanista da conceção instrumental, protésica da serviçalidade essencial da técnica, ao mesmo tempo que põe em causa que corpo, pertença a um género, desejo ou sexualidade possam ser o locus de resistência às relações de poder-saber tecnicamente mediadas. A animanidade sobre a qual estas operam na era da biopolítica engloba a totalidade sem resto da matéria-prima corpórea a todos os seus níveis, vegetativo, animal, de relação, e projeta-se nas políticas chamadas pós-emancipatórias em que o que está em causa não é já a definição e o exercício de direitos, liberdades e garantias da política iluminista clássica, mas a persecução experimental de modos de vida, de que é exemplo a contrasexualidade tecnoperformativa. A experimental life tecnofílica que funciona no plano da liberdade morfológica, tem, nno entanto, implicações políticas decisivas.
Uma vida filosófica: a PARRESIA socrática contra as coações do poder
Authors: Dal Pozzo Pez Tiaraju , Pavini Renan
Published: October 2024

Foucault demarca os limites da sociedade moderna a partir do conhecido deslocamento do estado soberano para o biopoder, através da relação poder, vida e morte. Sua tese é de que, antes do século XVIII, o soberano era simbolizado pelo gládio, que significava que ele exercia, sobre seus súditos, “o poder de causar a morte ou deixar viver”. A partir da época clássica, por uma transformação profunda nos mecanismos de poder, o direito sobre a morte desloca-se ao apoiar-se nas exigências de um poder que “gere a vida”. Nesta nova configuração, encontramos dois eixos do biopoder: as disciplinas (governo dos corpos dos indivíduos) e a biopolítica (governo da população). Até então, no pensamento de Foucault é marcado por uma constante coação dos mecanismos de poder-saber sobre o sujeito. Entretanto, no último momento do pensamento de Foucault, nomeado de uma “Ética” ou “Estética da existência”, o filósofo se volta aos gregos para encontrar um pensamento crítico em que os indivíduos não são meros efeitos de um poder que coage e assujeita, e sim de uma vida como obra de arte, uma vida filosófica, como pensaremos a partir de Sócrates.
Climate Change and Health: Preparing for the Future
Authors: Hassan Batool
Published: October 2024

Climate change presents a critical public health crisis, disproportionately affecting vulnerable populations worldwide. Rising temperatures lead to increased heat-related illnesses and worsened air quality, exacerbating respiratory and cardiovascular conditions. Wildfires release pollutants that further compromise health, while changes in weather patterns expand the range of infectious diseases. Low-income and indigenous communities face heightened risks due to limited resources and reliance on vulnerable ecosystems. Effective responses require strengthened healthcare systems, enhanced urban planning for resilience, public health campaigns, and advocacy for robust climate policies integrating health considerations.

Keywords: Adaptation, Climate Change, Public Health, Policy Advocacy.
Advocating Problem-Based Learning in Physiotherapy Education in Pakistan
Authors: Zaman Danish , Asif Ushna , Nawaz Aqsa , Khan Areeba
Published: October 2024

This letter advocates for integrating Problem-Based Learning (PBL) into physiotherapy education in Pakistan to bridge the gap between theoretical knowledge and clinical practice. Highlighting the current reliance on traditional teaching methods, it emphasizes PBL's potential to enhance critical thinking, clinical reasoning, and lifelong learning skills essential for effective patient care. Recognizing challenges in adoption due to institutional size and resource constraints, the letter calls for research to evaluate PBL's impact on student satisfaction, competencies, and lifelong learning outcomes, underscoring the need for educational reform in the evolving healthcare landscape of Pakistan.

Keywords: Problem-Based Learning, Physiotherapy Education, Pakistan, Educational Reform.
Effects of Center Based vs. Telerehabilitation using an Interval and Continuous Aerobic Training among Post-Coronary Revascularization Patients-A Randomized Controlled Trial
Authors: Zehra Fatima , Khan Muhammad Usman , Junejo Sanaullah , Khan Ammanullah , Memon Sabrina
Published: October 2024

Background: This investigation used continuous aerobic and high-intensity interval training to compare the differences between centre-based and telerehabilitation. This study seeks to identify the most efficient rehabilitation strategy positioned to empower patients on their path to recovery and well-being in the contemporary era of cardiac care.

Methodology: The study was a single-blinded, randomized controlled trial involving 80 patients who had undergone coronary revascularization procedures, were enrolled in the cardiac rehabilitation department, and were eligible for Phase-III CR. Patients were divided into Group A, receiving centre-based Continuous Moderate-Intensity Aerobic Exercise, 3–4 days a week, at 50%-70% of MHR. Group B received high-intensity interval-based training for 3–4 days and at four subsequent intervals. Telerehabilitation was conducted with Group C following the same protocol as Group A and Group D following the same protocol as Group B, while each group had n=20 participants.

Results: The within-group analysis showed significant improvements in the 6-Minute Walk Test (6MWT) and Self-reported Seven-Day Physical Activity Questionnaire (PAR) across all groups (p<0.001). Significant improvements in the Rate of Perceived Exertion (RPE) were found in Groups A and B (p<0.05). ANOVA results indicated that centre-based rehabilitation was significantly more effective than telerehabilitation in improving 6MWT and RPE scores (p<0.05).

Conclusion: Centre-based intervention is more effective than telerehabilitation in Phase-III Cardia Rehabilitation patients. However, high-intensity interval-based training was more effective in centre-based, while continuous moderate-intensity aerobic exercise was effective in telerehabilitation.

Keywords: Aerobic Exercises, Cardiac Rehabilitation, Coronary Artery, Physical Activity.
The Effects of High-Intensity Interval Training (HIIT) on Ovarian Function and Fertility Potential in Women
Authors: Afzal Sara , Kalsoom Faiza , Razzaq Sakina , Atif Namara , Noor Asma , Mahmood Asjad
Published: October 2024

Background: High-Intensity Interval Training (HIIT) has recently been recognized as one of the regimens encompassing various benefits for maintaining health across diverse populations. It is based on intense exercise with brief periods of rest or low-intensity activity, offering a time-efficient approach that appeals to individuals seeking maximal benefits with minimal time commitment.

Methodology: Women aged 18-40 years with regular menstrual cycles and sedentary or moderately active lifestyles attending outpatient physiotherapy clinics in Lahore were divided into HIIT groups which engaged in supervised sessions for 4 days/week for 12 weeks, performed alternating periods of high-intensity exercise on a stationary bike for 1 minute with periods of active recovery for 30 seconds at 80-90% THR. Participants in the control group performed supervised aerobic exercise sessions 5 days/week for 12 weeks and performed moderate-intensity continuous exercises on a stationary cycle at 70-75% THR for 30 minutes. The hormonal markers and the regularity of menstruation were assessed at baseline and post-intervention.

Results: Within-group analysis showed a notable increment in the level of estradiol and progesterone in both groups (p<0.05). Between-group analysis also exposed the HIIT group as being superior to the aerobic. (p<0.001).

Conclusion: The findings of the study demonstrated the effectiveness of HIIT and aerobic exercise in impacting the hormonal markers and the regularity of menstruation among obese women. Although, the HIIT showed greater efficacy in improvising estradiol and progesterone levels and reducing menstrual cycle length.

Keywords: Aerobic Exercise, Fertility, Interval Training, Obesity.
A ressignificação da ginga com tapioca à luz do Movimento Armorial e sua relação com o turismo
Authors: Marília Medeiros Soares  , Fernando Emerson Pereira
Published: October 2024

O presente estudo tem como objeto a ginga com tapioca, iguaria que tem como principal ponto de comercialização o Mercado Público da Praia da Redinha, em Natal/RN. Após ter sido considerada, em 2019, patrimônio imaterial do estado do Rio Grande do Norte, esse prato passou a fazer parte do cardápio de diversos restaurantes da cidade, sendo assim ressignificado através de preparações inovadoras. Dessa forma, o artigo tem como objetivo analisar, sob a perspectiva da gastronomia, as iniciativas de valorização da culinária potiguar através dessa preparação. Para tal foi utilizada a pesquisa documental e bibliográfica, com enfoque qualitativo e caráter exploratório, através de entrevistas junto a chefs de cozinha, do estudo de eventos gastronômicos e da análise dos cardápios de restaurantes da cidade. Para o estudo utilizou-se como referência o Movimento Armorial, lançado pelo dramaturgo e escritor Ariano Suassuna, onde sugere-se uma arte brasileira erudita a partir de suas raízes populares. Ademais, a chamada “gourmetização” de um prato tão popular se constitui em um procedimento de valorização da culinária local, contribuindo para o fomento ao turismo gastronômico e favorecendo a estruturação da praia que é seu berço, com a construção do Complexo Turístico da Redinha, o qual tem como principal produto a ginga com tapioca.
Observatório de Turismo da UEA e destinação do fundo FTI no Amazonas
Authors: Márcia Raquel Cavalcante Guimarães  , Maria Helena de Souza Fonsêca  , Lúcia Cláudia Barbosa Santos  , Ana Maria Oliveira de Souza  , Hugo Luiz da Silva Lima  , Rosângela López Alanís  , Ana Marta Cardoso Soares  , Evanilson dos Santos Ferreira  , Jakeline Cibelle Santos de Seixas  , Maria Vitória Rodrigues de Alvarenga  , Rosana de Araújo Oliveira  , Silvio Jorge Venâncio de Barros
Published: October 2024

O Fundo de Fomento ao Turismo, Infraestrutura, Serviços e Interiorização do Desenvolvimento do Estado do Amazonas (FTI) objetiva contribuir para o desenvolvimento socioeconômico do Estado em concordância com o Plano Estadual de Desenvolvimento. E para compreender as prioridades de destinação do recurso pela Empresa Estadual de Turismo do Amazonas (Amazonastur) entre os anos de 2011 a 2021, o Observatório de Turismo da Universidade do Estado do Amazonas realizou um estudo com base em pesquisa exploratória, utilizando metodologia própria para análise quali-quantitativa de notas de empenho apresentadas no portal da Transparência. Os resultados sinalizam destaque para destinação de recursos relacionados à promoção da marca Amazonas e a necessidade de maior expressividade da governança e planejamento estratégico para a construção de produto turístico bem estruturado e segmentos consolidados.
Editorial
Authors: D'sordi Alves Alegrini da Silva Sidcley
Published: October 2024

Apresentação da segunda edição da Revista Brasileira dos Observatórios de Turismo - ReBOT.
Myocardial Protective Effect of Xuebijing Injection on Extracorporeal Membrane Oxygenation Perfused Isolated Langendorff Heart Based on the PI3K/AKT Pathway
Authors: Yin Shijie , Yue Xiao , Wang Chunhua , Huang Qiangxin , Wu Wei , Qin Guanbin , Luo Lan , He Guixin
Published: October 2024

Objective: This study aimed to investigate the myocardial protective effect of Xuebijing injection in a model of extracorporeal membrane oxygenation (ECMO) isolated heart perfusion and determine the role of the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) pathway. Methods: To establish an ECMO isolated heart perfusion model, Guangxi Bama miniature pigs were randomly divided into two groups: (1) a normal saline group (NS group), in which 50 mL of normal saline was added to the perfusion solution; and (2) a Xuebijing injection group (XBJI group), in which 10 mL of XBJI was added to the perfusion solution and then continuously pumped at 5 mL/h. Perfusion was maintained for 8 h. The hemodynamic changes, inflammatory response, and myocardial enzyme levels at T0, T2, T4, T6, and T8 were evaluated. The protein expression level of the PI3K/AKT pathway was analyzed by Western blot analysis and Reverse Transcription Quantitative Polymerase Chain Reaction (RT-qPCR). Hematoxylin and eosin staining and transmission electron microscopy were used to observe the pathological morphology and ultrastructure of T8 cardiomyopathy. Results: There was no significant difference in hemodynamics between the two groups. XBJI could reduce serum inflammatory factors and myocardial enzyme levels. XBJI also upregulated the expression of PI3K and AKT mRNA and the phosphorylation levels of PI3K and AKT proteins. The results of pathological and electron microscopy showed that XBJI effectively reduced myocardial cell and mitochondrial damage. Conclusion: XBJI can reduce myocardial inflammation and myocardial cell and mitochondrial damage in isolated heart perfusion. XBJI may play a role in the myocardial protection of ECMO isolated heart perfusion by activating the PI3K/AKT pathway.
Pelatihan Branding Produk dan Strategi Konten Kreator Instagram untuk UMKM di Desa Gadingrejo-Juwana-Pati
Authors: Luthfi M. , Kurniawan Fajar Adhi , Nashiruddin Ahmad , Mu’ad Ahmad
Published: October 2024

Tujuan dari kegiatan pengabdian adalah membekali pelaku UMKM di Desa Gadingrejo tentang pentingnya branding produk yang kuat serta strategi membuat konten media sosial Instagram yang efektif. Kegiatan ini diikuti oleh sebanyak 26 peserta yang mayoritas bergerak bada bidang makanan olahan. Pengabdian ini menggunakan pendekatan ABCD. Pendekatan ABCD adalah sebuah paradigma yang menekankan pentingnya mengenali dan mengembangkan aset, potensi, dan kekuatan yang dimiliki oleh komunitas. Dalam pengabdian ini dilakukan dengan empat langkah yaitu discovery, dream, design dan destiny. Hasil pelatihan ini menunjukkan jika semula para pelaku UMKM dalam menjalankan usahanya masih sangat tradisional hanya sebatas membuat produk dan memasarkannya secara terbatas lokal desa. Setelah mengikuti pelatihan muncul semangat baru dan optimisme dalam membesarkan usaha UMKM yang mereka jalankan. Peserta pelatihan sangat antusias mengikuti pelatihan karena wawasan mereka terbuka dan timbul optimisme untuk membesarkan branding produk dan jangkauan pemasaran sehingga dapat meningkatkan omset pendapatan mereka.
Why H. G. Gadamer’s “Philosophical Hermeneutics” Cannot Belong to the “Metaphysics of Presence”?
Authors: Mickevičius Arūnas
Published: October 2024

H. G. Gadamer’s “philosophical hermeneutics” elicited a controversial response in contemporary philosophy. R. Rorty and G. Vattimo tried to impart a more relativistic shade to H. G. Gadamer’s hermeneutics. In contrast, J. Derrida was inclined to consider H. G. Gadamer hermeneutics more dependent on the previous epoch of “metaphysics of presence”. This article purposes to reveal the points of contact and division between the thinking strategies employed by hermeneutics and deconstruction, providing theoretical arguments why H. G. Gadamer hermeneutics should not be reduced to the so-called “metaphysics of presence”. The question whether H. G. Gadamer’s hermeneutics belongs to “metaphysics of presence” or not is closely intertwined with the problem of dogmatism of meaning and relativism of meaning. J. Derrida was inclined to regard H. G. Gadamer’s hermeneutic as a theory of a search for and discovery of a pre-existing or objective meaning which accounts for the theory’s persistent belonging with metaphysical dogmatism. In opposition to such judgement, this article seeks to substantiate the following thesis: in H. G. Gadamer’s hermeneutics which is based on the “good will” to understand, the problem of dogmatism of meaning (there is one universal objective meaning or truth) and relativism of meaning (there is a multitude of meanings open to interpretation without reference to the primary signified) can be solved by taking into consideration the way offered by E. Husserl phenomenology, i.e. by understanding any possible “thing” (die Sache) as a “thing-in-itself” only in different perceptual perspectives (die perspektivischen Abschattungen).
Cuidados paliativos:
Authors: Leal de Oliveira Felipe , Mendes Santos Jéssica , Vinicius Alves dos Santos Lucas , Aparecido de Souza Renato , Honório Pereira Tatiana , Aguiar de Oliveira Thais , Gomes de Araujo Vinicius , Roberto da Silva Júnior Paulo
Published: October 2024

Esta pesquisa buscou analisar as estratégias adotadas por profissionais da psicologia nos cuidados paliativos a pacientes com câncer e a seus familiares, além de avaliar os progressos e limitações nesse campo. A metodologia empregada foi qualitativa e exploratória, com uma revisão bibliográfica integrativa de artigos científicos relevantes e a realização de entrevistas presenciais com duas psicólogas atuantes no contexto oncológico. A análise revelou que um desafio vivenciado pelas psicólogas refere-se à amenização do desespero de uma família ou cuidador que deseja fazer de tudo para que seu ente permaneça vivo, sem considerar, muitas vezes, a vontade do principal envolvido. Outro desafio refere-se à limitação do tempo para auxiliar o paciente dentro de sua individualidade a ressignificar sua vida frente à morte, levando-se em consideração a terminalidade rápida em alguns tipos de câncer. Conclui-se que os cuidados paliativos têm como objetivo oferecer proteção e conforto aos/às pacientes e familiares em momentos difíceis, e o profissional da Psicologia cumpre um importante papel nesse processo, mas deve estar atento sobre como a sobrecarga emocional e as dúvidas sobre como ajudar pacientes terminais podem afetar sua saúde mental.
A educação contemporânea:
Authors: Starlin Erse Cristiano
Published: October 2024

O presente artigo científico tem como objetivo realizar uma análise crítica da educação contemporânea, questionando a ideia de ruptura entre metodologias tradicionais e modernos. A partir de uma revisão de literatura e dados documentais, demonstra-se que muitas metodologias tratadas como inovadoras são adaptações de ideias clássicas de autores como John Dewey e Paulo Freire. O estudo discute também a interdependência entre o ensino de conteúdo e o desenvolvimento de habilidades, desmistificando uma possível dicotomia entre ambos. Por fim, o artigo sugere que o discurso de inovação na educação pode ser mais uma estratégia mercadológica do que uma realidade substancial, defendendo a integração equilibrada de métodos tradicionais e inovadores para uma educação eficaz.
Intoxicação por teobromina em cães:
Authors: Cardoso Bertolino Fábio , Gomide do Valle Pillar
Published: October 2024

Este trabalho busca reunir informações acerca do fruto do Cacau (Theobroma cacao) e o seu potencial tóxico aos cães devido à um alcaloide presente em seu fruto e derivados, encontrado em quantidades suficientemente tóxicas em chocolates, chamado de teobromina. Inúmeros trabalhos relatam a gravidade do consumo de chocolate por cães e poucos abrangem as características do cacau e o mecanismo de ação da teobromina no organismo dos cães e é de extrema importância que seja elucidado para correta intervenção veterinária (KWIK-URIBE, 2005; LATIF, 2013). Avalia-se o teor das metilxantinas, teobromina e cafeína que são encontrados em subprodutos do Cacau, seu potencial tóxico, dose letal, sinais clínicos descritos na literatura e o tratamento adequado para estabilização do quadro de intoxicação desencadeados pelo consumo acidental ou espontâneo do chocolate por cães (ASHIHARA, 2006). A presença do chocolate nas casas é mais frequente em feriados como a Páscoa, cuja tradição de presentear alguém com ovos elaborados com os mais diversos ingredientes e tendo como base o chocolate, pode aumentar a incidência de atendimentos de emergência e urgência de casos de intoxicação em clínicas veterinárias (RODER, 2002).
O Instituto da guarda compartilhada aplicada ao direito do animal
Authors: Reis Rocha Rafael , Gomes dos santos Luciano
Published: October 2024

O presente estudo aborda a relevância do debate e da reflexão acerca da guarda compartilhada de animais domésticos no contexto brasileiro, subsequente à dissolução matrimonial e à ruptura da união estável. Destaca-se a integração do animal doméstico no núcleo familiar, configurando o que se denomina família multiespécie, e procura-se examinar a abordagem jurídica conferida a esses seres no seio da entidade familiar. Para tanto, procede-se a uma análise doutrinária e jurisprudencial, assim como um estudo comparativo com a legislação nacional e o direito internacional.
Use of Mixed Reality Technologies by Orthopedic Surgery Residents: A Cross-Sectional Study of Trainee Perceptions
Authors: Gupta Nithin , Walker Jamison , Turnow Morgan , Kasmenn Maxwell , Patel Hursch , Sydow Emily , Manes Taylor , Williamson Tyler , Patel Jignesh
Published: October 2024

Introduction

Recently within surgical education, the development of extended reality (XR) devices has become a topic of interest to improve trainees’ surgical technique outside of the operating room. There is a growing body of literature which supports the use of XR, and it is important to understand the perceptions of orthopedic surgery trainees on the use of XR as an adjunct during training.

Purpose

Understand the perceptions of orthopedic trainees on the use of XR as an adjunctive surgical training tool.

Methods

An internally validated 18-question survey was sent to all US orthopedic residency program coordinators with the intent for distribution to each program’s respective residents. Responses with ≥ 70% completion were considered complete.

Results

Overall, 33% and 18% of residents agreed XR is needed, and all programs should offer XR, respectively. There was overall agreement (67%) for XR’s ability to improve procedural confidence and improve skill progression (65% agreed). Only 25% of respondents felt XR could accurately simulate orthopedic procedures and 36% agreed it could effectively model patient-specific anatomy for preoperative planning. Regarding XR’s ability to reduce intraoperative navigational error, 45% of respondents agreed. However, responses were more neutral for XR’s ability to reduce inpatient length of stay (40%) and ability to improve the accuracy of hardware/prosthetic placement (31%). Finally, 53% of respondents agreed that the largest barrier to integration of XR is cost, while 35% felt that a lack of dedicated time to use the technology during their training program was a major barrier.

Conclusion

The need for adjunctive surgical training outside of the operating room is clearly demonstrated from our results. Although it is unclear if XR will become a standard tool across all residency programs, orthopedic surgery residents do feel that the technology is useful in terms of skills progression and operative confidence. Thus, this study provides a preliminary framework which suggests a potential role for XR in orthopedic surgery training and the need for further study to address barriers to widespread integration.
Issues and Challenges of Implementing Special Education (SPED) Curriculum in the Philippines: A Systematic Literature Review
Authors: Espeño Sheena , Babiano Emilia H. , Bucoy May Lanie R. , Busime Eleonor L. , De Borja Joanna Marie A.
Published: October 2024

This systematic literature review examines the issues and challenges in implementing the Special Education (SPED) curriculum in the Philippines. Despite legislative efforts, numerous obstacles hinder effective implementation, including inadequate funding, insufficient teacher training, curriculum inflexibility, social stigma, and infrastructural barriers. This review synthesizes findings from various academic articles, government reports, and organizational publications to comprehensively understand these challenges. It recommends policy enhancements, resource allocation, teacher training, curriculum adaptation, and stakeholder involvement to improve SPED implementation in the Philippines. The research uses Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to determine and choose the articles used in this systematic literature review. From over a thousand related articles, the researchers narrowed it down to fifteen (15) related articles following inclusion and exclusion criteria. The report offers evidence-based recommendations to address these difficulties, with the goal of policy reforms and improving their efficacy.
EFFECTIVE TEACHING METHODS FOR TURKISH LEARNERS OF KOREAN BY CONTRASTIVE TYPE: EVALUATED BY DETAILED ACCESSMENT ITEMS
Authors: Yang Soyoung
Published: October 2024

In order to develop an effective teaching method in the perspective of contrastive analysis on Korean and Turkish, the two languages were contrasted and categorized into six contrastive types. Effective teaching methods for each contrastive type were analyzed according to the experimental group—the Consecutive Translation and Back Translation teaching methods, and the control group—the Focus on Form teaching method. Afterwards, the effectiveness of the teaching methods according to evaluation items were verified by contrastive type for beginner’s level group. The results showed that between the two translation teaching methods, Consecutive Translation method is effective for types of 'Korean same as Turkish', ‘Many in Turkish corresponding to one in Korean’, and the type most requiring the Turkish language in teaching, the 'Korean different from Turkish' type. Additionally, the Back Translation method is most effective for ‘Absent in Turkish but split in Korean’ type, which was ranked to be the most difficult to learn. In addition, with Focus on Form method for ‘One Turkish corresponding to many in Korean’ type, which was ranked the highest in terms of importance, learning priority. This study applied the Contrastive Analysis approach to utilize the contrastive types, and thus verified the effectiveness of the translation method in identifying teaching methods.
Korece ve Türkçe üzerinde Karşılaştırmalı Analiz perspektifinde etkili bir öğretim yöntemi geliştirmek için iki dil karşılaştırılmış ve altı karşılaştırmalı yapıya ayrılmıştır. Her bir karşılaştırmalı yapı için etkili öğretim yöntemleri deney grubu - Ardıl Çeviri ve Tersine Çeviri öğretim yöntemleri ve kontrol grubu - Biçim Odaklı öğretim yöntemine göre analiz edilmiştir. Bu şekilde değerlendirme alanlarına göre öğretim yöntemlerinin etkililiği, başlangıç seviyesi grubu için karşılaştırmalı yapıya göre doğrulanmıştır. Sonuçlar, iki çeviri öğretim yöntemi arasında Ardıl Çeviri yönteminin, 'Korece Türkçe ile aynı', ‘Türkçede çoklu karşılıklı’ ve Türkçeye en çok ihtiyaç duyulan ‘Türkçe ile farklı’ yapılarında etkili olduğunu göstermiştir. Ayrıca, Tersine Çeviri yöntemi, öğrenilmesi en zor olarak sıralanan ‘Türkçede bulunmayıp Korecede bölünmüş olan’ yapısında en etkili yöntemdir. Buna ek olarak, önem ve öğrenme önceliği açısından en üst sırada yer alan ‘Korecede çoklu karşılıklı’ yapı için Biçim Odaklı yöntem en etkili yöntemdir. Bu çalışma, Karşılaştırmalı Analiz yaklaşımını uygulamış ve böylece çeviri yönteminin öğretim yöntemlerini belirlemedeki etkinliğini doğrulamıştır.
DEPARTAMENTALIZAÇÃO NAS ORGANIZAÇÕES EMPRESARIAIS: CONCEITOS E APLICAÇÕES
Authors: Teixeira Moacir José , Moreira dos Santos Pinheiro Michel
Published: October 2024

A busca pela eficiência e eficácia no ambiente empresarial faz com que as empresas desenvolvam estratégias para maximizar o uso dos recursos disponíveis, em especial, os recursos humanos. Nesse sentido, uma das atividades empresarias mais antigas, e aplicadas até os dias atuais, é a divisão do trabalho em departamentos, ou departamentalização. Diante do exposto, o objetivo deste estudo é apresentar a departamentalização como ferramenta de gestão para as organizações, ressaltando seu caráter estruturalista e hierárquico, e adicionando à essas bases iniciais novas visões que surgiram ao longo do tempo. Para isso, realizou-se um estudo envolvendo uma empresa nacional de pequeno porte e, posteriormente, uma comparação com uma empresa multinacional de grande porte. Constatou-se que a empresa de pequeno porte, pelo fato de possuir menor contingente de recursos humanos, tem mais dificuldade na divisão do trabalho, quase sempre culminando com acúmulo de funções nos departamentos.
TASKS FOR THE PREVENTION OF NATURAL EMERGENCIES IN THE WATER AREAS OF THE SEAS OF THE RUSSIAN ARCTIC (BASED ON THE MATERIALS OF THE MARITIME DOCTRINE OF THE RUSSIAN FEDERATION)
Authors: Gordienko Aleksey
Published: October 2024

This article provides an overview of the main organizational and managerial tasks to ensure protection from natural emergencies during marine activities in the Arctic zone of the Russian Federation.
The main mechanism for ensuring the safety of maritime economic activity in the Arctic is called the prevention of emergency situations by forecasting them. The problems of natural (climatic extremes) emergencies are emphasized, the main directions of obtaining predictive information, scientific and scientific-technical activities, and the tasks of legal regulation are briefly outlined.
The guideline for the presentation of the topic of the article is the Maritime doctrine of the Russian Federation – a strategic act of the Head of state, which contains the main provisions on the principles and mechanisms of maritime activities in the Russian Federation.
The result of this study is the positioning of emergency forecasting as an inseparable segment of activity in the Arctic from the economy.
SOME PROBLEMS OF THE RECEPTION OF FOREIGN LAW BY RUSSIAN CIVIL LEGISLATION
Authors: Sidorova Valentina
Published: October 2024

The article examines the problems that have arisen as a result of the reception of foreign law by modern Russian civil law and civil legislation in terms of money and securities, and also substantiates the need to change the methods of protection for monetary obligations. The author believes that the conclusions obtained as a result of the conducted research allow us to speak about the relevance of the development of a unified economic and legal theory of money and the need to introduce a new comprehensive interdisciplinary economic and legal direction in Russian science and in Russian legislation.
ISSUES OF IMPROVING REGULATION IN THE FIELD OF REMUNERATION (MONETARY ALLOWANCE) OF RESCUERS AND FIREFIGHTERS WORKING (SERVING) IN THE ARCTIC ZONE OF THE RUSSIAN FEDERATION: LAW-MAKING ASPECT
Authors: Zozulya Alexandr , Nemchenko Stanislav , Smirnova Anna , Utkin Nikolay , Sulima Timofey
Published: October 2024

The article considers legal incentives in the field of remuneration (monetary allowance) of firefighters and rescuers of the Arctic group of EMERCOM of Russia, in order to identify the existing problems of regulation. The study systematized the guarantees and compensations provided for by the legislation in the designated area, conducted a comparative analysis of the legal regulation
of the relations under consideration for various categories of employees (employees) of EMERCOM of Russia in terms of modern goals and objectives of state policy in the Arctic, taking into account differentiation by territories of the Arctic zone. Some differences have been established in the procedure for applying a percentage supplement to the wages (monetary allowance) of rescuers and firefighters, which are not due to the peculiarities of the legal status of these entities, but are a consequence of the fragmentation of legal regulation. A number of proposals have been formulated to improve the applicable legislation.
Evaluación de la NOM-037: Un estudio descriptivo de caso en una universidad particular
Authors: García Parada Ricardo , Silva Maynez Lucía Xiomara , Marrón Ramos Domingo Noe , Avila Pérez Tagle Alfonso , Hernández Ramírez Luis Fernando
Published: October 2024

El estudio tiene como propósito principal es identificar las prácticas exitosas y los desafíos que surgen al aplicar esta normativa, y cómo impacta en la experiencia y bienestar de los docentes involucrados. El enfoque de la investigación fue cuantitativo y exploratorio, basado en encuestas aplicadas a diez profesores de posgrado que imparten clases en modalidad de teletrabajo. Se utilizó una lista de verificación basada en los lineamientos de la NOM-037, evaluando aspectos ergonómicos, iluminación, ventilación, conectividad, entre otros. Los datos se procesaron mediante el software SPSS para analizar las respuestas y medir la confiabilidad de los elementos evaluados mediante el coeficiente alfa de Cronbach (0.897). El estudio reveló que la implementación de la NOM-037 en esta institución presenta resultados positivos, con una mayoría de profesores satisfechos con las condiciones de teletrabajo y la capacitación recibida. Sin embargo, se identificaron áreas de mejora en aspectos como la calidad del mobiliario y el ruido ambiental, que afectan la salud visual y postural de los docentes. En términos generales, la aplicación de la norma ha mejorado la seguridad y salud en el teletrabajo, pero se requieren ajustes en la infraestructura para optimizar las condiciones laborales y prevenir problemas de salud a largo plazo.
Profesores: intelectuales, profetas y víctimas. La valorización de la figura del docente
Authors: Alvarado Borgoño Miguel Ernesto
Published: October 2024

Este artículo trata el tema de la visión social y la contingencia concreta de la profesión docente en el contexto chileno, abordando el período que va desde principios del siglo XX hasta la actualidad. Se trata de plantear que la ubicación desmedrada de la figura del profesor en el imaginario social y por tanto en la conciencia colectiva, es substancialmente una forma de violencia estructural que está normalizada, que guarda relación antes que nada con un proyecto político y específicamente geopolítico, desarrollado durante la dictadura militar chilena (1973-1989), y que vio al profesorado como un enemigo. Los efectos de este proceso de desmedro de la función docente y de la imagen social del profesor aún no son superados, y a pesar de algunas medidas concretas que son altamente valorables, no existe un giro sociocultural y sociopolítico que radicalmente reubique la visión del profesor en aquello que fue el educador durante las primeras décadas del siglo XX.