bluuebunny/crossref_metadata_2025 huggingface dataset:
Genome-wide association study adjusting for familial relatedness identifies novel loci for food intake in the UK Biobank
Authors: Hoang Tung , Cho Sooyoung , Choi Ji-Yeob , Kang Daehee , Shin Aesun
Published: August 2023

This study aimed to identify genetic risk loci associated with dietary intake using recently revealed data of over 93 million variants from the UK Biobank. By adjusting for familial relatedness among individuals in a linear mixed model, we identified a total of 399 genomic risk loci for the consumption of red meat (n = 15), processed meat (n = 12), poultry (n = 1), total fish (n = 28), milk (n = 50), cheese (n = 59), total fruits (n = 82), total vegetables (n = 50), coffee (n = 33), tea (n = 40), and alcohol (n = 57). Of these, 13 variants in previous study did not reach suggestive significant level (p = 1.0e-5). Under the LDAK model, the heritability (h2) was highest for the consumption of cheese (h2 = 10.48%), alcohol (h2 = 9.71%) and milk (h2 = 9.01%), followed by tea (h2 = 8.34%) and fruits (h2 = 7.83%). Of these, the highest genetic correlation (r2) was observed between milk and tea consumption (r2 = 0.86). Post-GWA analyses were further conducted to identify variant annotations and functional pathways using summary statistics. Overall, by analyzing the updated data with adjustment for familial relatedness in this large-scale database, we identified several novel loci for food intake. Further investigations in other populations are needed to understand the contribution of genetic factors to dietary habits in populations of various ethnic backgrounds.
A multiplex crystal digital PCR for detection and quantitation of porcine circovirus type 2 and type 3
Authors: Shuai Jiangbing , Chen Kexin , Wang Zhongcai , Zeng Ruoxue , Ma Biao , Zhang Mingzhou , Song Houhui , Zhang Xiaofeng
Published: August 2023

Porcine circovirus (PCV) has become one of the major diseases costing huge economic losses in global pig industry, and PCV type 2 (PCV2) and 3 (PCV3) infections are widespread worldwide. A multiplex crystal digital PCR (cdPCR) was developed with three pairs of specific primers and corresponding probes targeting the Rep region of PCV2, the Cap region of PCV3, and an external process control gene (EPC), respectively, after optimization of the concentration of primers and probes, and annealing temperature. The results showed that the multiplex cdPCR exhibited precise and differential detection capabilities for PCV2 and PCV3 with limit of detection of 1.39×101 and 1.27×101 copies/reaction respectively, whereas no cross-reaction with other porcine viruses. The intra-assay and inter-assay coefficients of variation (CV) were less than 8.75%, indicating good repeatability and reproducibility. Then, PCV2 and PCV3 were detected simultaneously in 40 tissue samples and 70 feed samples with cdPCR and quantitative PCR (qPCR). For tissue samples, crystal dPCR and qPCR had similar positive rates for PCV2 (52.17% vs 54.35%), PCV3 (4.35% vs 2.17%) and co-infection of both viruses (13.04% vs 10.87%). However, in feed samples, the positive detection rate of PCV2 (20%) and co-infection (12.86%) by the cdPCR was surprisingly higher than the qPCR (12.86% and 0%). Accordingly, the highly specific and sensitive multiplex crystal dPCR allowed us to accurately detect PCV2 and PCV3 simultaneously, and is particularly well suited for applications that require the detection of small amounts of input nucleic acid or samples with intensive processing and complex matrix.
Diosmetin induces apoptosis and protective autophagy in human gastric cancer HGC-27 cells via the PI3K/Akt/FoxO1 and MAPK/JNK pathways
Authors: Pan Zhaobin , Tan Zhiming , Li Hongyan , Wang Yang , Du Haiyan , Sun Jinhui , Li Chunchao , Ye Shicai , Li Xin , Quan Juanhua
Published: August 2023

Gastric cancer represents a significant global health concern, necessitating the exploration of novel therapeutic options. Diosmetin, a natural flavonoid derived from citrus and vegetables, has demonstrated promising anti-tumor activity against various tumor cells. However, the potential anticancer effect of diosmetin in gastric cancer and its underlying mechanism have yet to be elucidated. In this study, we aimed to investigate the impact of diosmetin on cell proliferation, migration, cell cycle progression and apoptosis in human gastric cancer HGC-27 cells. Our findings revealed that diosmetin effectively suppressed cell proliferation, induced G2/M phase cell cycle arrest, and triggered cell apoptosis. Mechanistically, diosmetin downregulated the expression of antiapoptotic proteins Bcl-2 and Bcl-xL, while upregulated the level of proapoptotic proteins such as Bax, cleaved PARP and cleaved caspase-3. Additionally, diosmetin inhibited Akt and FoxO1 phosphorylation, while activated the MAPK signaling pathway. Notably, pretreatment of IGF-1, an Akt activator, attenuated the diosmetin-induced apoptosis. Furthermore, pretreatment with SP600125, a JNK inhibitor, significantly reduced the protein level of LC3B, while promoted the expression of cleaved caspase-3 and cleaved PARP. Collectively, our results suggest that diosmetin holds promise as an effective therapeutic agent against gastric cancer by inducing apoptosis through inhibition of the Akt/FoxO1 pathway and promoting protective autophagy via the MAPK/JNK signaling pathway.
The silencing of the L1-MET chimeric transcript activates cancer cell death program and inhibits the expression of crucial oncoproteins in lung cancer cells
Authors: Miglio Umberto , Berrino Enrico , Avanzato Daniele , Molineris Ivan , Miano Valentina , Milan Melissa , Lanzetti Letizia , De Bortoli Michele , Sapino Anna , Venesio Tiziana
Published: August 2023

Background
Among the antisense chimeric sequences generated by intragenic long interspersed nuclear elements (LINE1s), L1-MET transcript, within MET oncogene, is of particular interest since its expression, activated by promoter hypomethylation, has been associated with the acquisition of cancer phenotype. L1-MET can originate several isoforms, but it is unable to form stable proteins. Presently, its biological functions remain unknown.
Methods
To investigate the role of L1-MET, we silenced its expression on selected lung and breast cancer cells, characterized by variable levels of L1-MET and MET mRNA, using specifically-modified targeting antisense oligonucleotides. In addition to viability and apoptotic rate, the transfected cells were compared for their gene expression profiles and the protein level of identified downregulated cancer genes.
Results
Besides a considerable decrease of cell viability and increase of apoptosis, transiently transfected cancer cells partly rewrote their gene expression profiles, with an effect related to the L1-MET/ MET mRNA level and the type of cells, being particularly strong in lung cancer cells. In particular, MET and EGFR genes, activated in EBC1 lung cancer cells, but at the steady-state level in the other tested cell lines, showed a significant downregulation of MET and EGFR oncoproteins, with a specific loss of the AKT phosphorylation and a decrease of phospho-ERK, in the case of EBC1 cells. No effects were evidenced in non-transformed fibroblasts and human lymphocytes, used as controls.
Conclusions
Our results clearly demonstrate the ability of L1-MET to interfere with the expression of MET and EGFR oncoproteins in selected cancer cells. The expression of L1-MET, strictly limited to transformed cells, makes its silencing an ideal approach to induce tumor cells to death and a potential inhibitor of crucial oncoproteins on which cancer cells rely for their survival and proliferation, such as lung cancer cells.
Morphological and cytoskeleton changes in cells after EMT
Authors: Nurmagambetova Assel , Mustyatsa Vadim , Gladkih Aleena , Vorobjev Ivan
Published: August 2023

Epithelial cells undergoing EMT experience significant alterations at transcriptional and morphological levels. However, changes in the cytoskeleton, especially cytoskeleton dynamics are poorly described. Addressing the question we induced EMT in three cell lines (MCF-7, HaCaT and A-549) and analyzed morphological and cytoskeletal changes there using immunostaining and life cell imaging of cells transfected with microtubule and focal adhesion markers. In all studied cell lines, cell area after EMT increased, MCF-7 and A-549 cells become elongated, while HaCaT cells kept aspect ratio the same. We next analyzed three components of the cytoskeleton: microtubules, stress fibers and focal adhesions. The following changes were observed after EMT in cultured cells: (i) Organization of microtubules becomes more radial; and growth rate of microtubule plus ends was accelerated; (ii) Actin stress fibers become co-aligned forming the longitudinal cell axis; and (iii) Focal adhesions had decreased area in all cancer cell lines studied, and became more numerous in HaCaT cells. We conclude that among dynamic components of the cytoskeleton the most significant changes during EMT happen in the regulation of microtubules.
Crop Diversity Index Assessment for Telangana State Using Remote Sensing
Authors: Kumar Ammaladinne Tharun , Biswal Anima , Sreeni Gade , Venkataramana M. , Madhavi A , Kumari R. Vijaya
Published: August 2023

In this study, crop diversity index (CDI) was computed for Telangana Rabi season at mandal level with the help of crops area calculated by using remote sensing. Sentinel 2A and 2B MSI L2A products were processed and obtained time series normalized difference vegetation index (NDVI) images. Pure cropped pixels were extracted for major Rabi crops based on ground truth data using the NDVI Composite index, which comprises of temporal profiling of time series NDVI. Hybrid method which uses phenology-based decision rules and unsupervised classification was used to delineate Rabi crop area. The cropped area provided by the Govt. agency and the remote sensing based cropped area estimates have showed a good correlation. To measure agricultural diversification at the mandal level, the Gibbs and Martin formula (1962) of crop diversification index was used to generate the crop diversity index values, which solely considers net planted area of crops during Rabi season. The findings demonstrate that, assuming identical geo-climatic and socio-economic conditions, the amount of land cultivated for each crop changes at the Mandal level with changes in terrain, soil types, irrigation capabilities, distance from main crop markets and government policies.
Construct fluorescent solid lipid nanoparticles from bacterial outer membrane vesicles to investigate their characteristics and applications
Authors: Kaliyaperumal Viswanathan , Manivannan vimal , Karuppan Chitra , Gopal Dhinakararj , Muthusamy Raman
Published: August 2023

In this study, the new solid lipid nanoparticles were created by combining fluorescent dye, fatty acid, lipid, and bacterial outer membranes. The synthesised particles were roughly 95–100 nm in size. Vero cells cultivated with these nanoparticles showed no cytotoxicity in 5-dimethylthiazol-2-yl-2, 5-diphenyltetrazolium bromide (MTT) assay. In the cell uptake studies, the vero cell line was employed. Cell lines absorbed fluorescent solid lipid nanoparticles (FSL NPs) better, according to the findings. The confocal microscopy results revealed a significant accumulation of FSL NPs in the cytoplasm over time. The results of small animal imaging employing BALB/c mice revealed that the nanoparticles generated provided high contrast signals. Overall, the OMVs-based FSL NPs system offers a unique imaging tool for studying intracellular interactions as well as a viable tool for drug delivery.
Comparative Efficacy of Sodium Metasilicate and Organic Source Combination on Sugarcane (Saccharum officinarum L.) for Reducing the Post-harvest Deterioration Losses
Authors: Anitha R. , Brindavathy R. , Srith N. , Jagathjothi N. , Priya R. Sathya , Yuvaraj M. , Jaiby C. , Dhanushkodi V. , Thirumurugan T. , Sujatha K. B. , Thiruvarassan S. , Jeyakumar P. , Sassikumar D. , Jayachandran M.
Published: August 2023

Sugarcane must be processed quickly after being harvested because it is a destructible commodity. Harvested cane may degrade for a variety of reasons, including exposure to microbes, mechanical or manual harvesting, cultivar, maturity, cut-to-crush interval, and storage. Due to the quick loss of sucrose and deterioration after harvest, sugarcane needs to be treated at the right time and way. The higher sugar content of mature internodes offers the perfect conditions for microbial growth, which enters the harvested stalk through wounds or cut ends. The bacteria Leuconostoc spp. is primarily responsible for these post-harvest losses, which negatively affect sugar percent. The trials were carried out to assess the efficacy of Sodium metasilicate (SMS), Benzalkonium chloride (BKC), Nisin (Lactobacteria), and Neem sources on sugarcane for reducing the post-harvest degradation losses. An investigation is underway now to reveal that foliar spray of neem cake @ 5% + dried neem leaves extract @ 5% (in heaping) is the most effective and eco-friendly substance that might be able to significantly enhance sugar recovery. This treatment was comparable with the chemical formulation of SMS @ 2% (3 days before harvest) + BKC @ 2000 ppm (in heaping) which might be a consequence of controlling the proliferation of Leuconostoc spp. bacterium. Likewise, the juice obtained from these treatments has a lower rate of inclination in pH, reducing sugar, total soluble solids, titrable acidity index, invertase activity, higher sucrose, and commercial cane sugars (CCS) recovery, furthermore with relatively smaller losses in cane weight. Hence, these treatments offer a significant potential role in reducing post-harvest deterioration losses in the sugar industry.
MgAl2O4 nanospinel: Green synthesis, Characterization and effective heterogeneous catalyst for the photocatalytic degradation of Carbol Fuchsin dye and synthesis of 2-Aryl substituted Benzoxazole derivatives
Authors: NITHA T.V. , BRITTO S.
Published: August 2023

In this study we report, plant extract mediated green, expedient, cost effective and environment friendly synthesis of MgAl2O4 nanospinel and their potential application in the field of photocatalytic degradation of organic contaminant and biologically active benzoxazole synthesis. The synthesized spinel material was characterized by XRD, FT-IR, FE-SEM, EDAX, TEM UV-Visible spectra, XPS and BET. Sunlight driven photocatalytic degradation efficiency of this catalyst was performed on a widely used industrial dye carbol fuchsin (CF) which is a major contaminant that is being mixed in water resources. The contamination could be degraded upto 96.84% when its concentration is 30 ppm at pH 9, by the nanospinel of 0.6 g/L. Kinetic model of degradation follows pseudo- first order kinetic with rate constant of 0.043 min− 1. Also the nanospinel has the key benefits in the synthesis of some benzoxazole derivatives as a catalyst, that its shorter reaction time, excellent yield, safety and moderate reaction conditions, non-toxicity and simple work up procedures.
Genetic Predisposition of Diabetes to Coronary Artery Disease Due to ApoE Gene Polymorphism Using Allele Discrimination Real-Time Analysis as a Diagnostic Tool
Authors: Salman Mohammed Noori , aljanabi Abdulhussein Alwan Faraj , Al-Kashwan Thekra Abid Jaber
Published: August 2023

BackgroundThe Apolipoprotein E (ApoE) gene plays a pivotal role in facilitating the removal of lipoproteins and stands as a prominently investigated candidate in the context of type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD). Lipoprotein-linked mechanisms have been implicated in causing cardiovascular impairment among individuals with diabetes. This research was conducted to ascertain the relationship between ApoE genetic variations and the occurrence of T2DM with CAD, as well as its influence on the levels of lipids in the bloodstream within the Iraqi population. These findings offer potential avenues for primary prevention against the onset and progression of bothT2DM and CAD.MethodThis study was conducted based on 400 participants, subdivided into 200 T2DM patients with coronary artery disease and 200 normal individuals. To assess the potential risk association of ApoE, logistic regression analysis was employed to derive odds ratios (OR) and corresponding 95% confidence intervals (CI).ResultsThe frequency ratio of the E3/E4 genotype and the ϵ4 allele among patients affected by both CAD and T2DM exhibited a clear increase. The odds ratios (OR), accompanied by their respective confidence intervals (CI) and p-values, were detailed as follows: for carriers of the E3/E4 genotype, the OR was 4.8 with a 95% CI of 2.4 to 9.46, and a p-value of 0.0001; for E2/E2 carriers, the OR was 1.3 with a 95% CI of 0.18 to 9.21, and a p-value of 0.81; for E2/E3 carriers, the OR was 0.89 with a 95% CI of 0.46 to 1.7, and a p-value of 0.7; for E2/E4 carriers, the OR was 3.84 with a 95% CI of 0.4 to 37.34, and a p-value of 0.25; and for E4/E4 carriers, the OR was 4.3 with a 95% CI of 1.15, and a p-value of 0.03. In comparison to the ϵ3/3 genotype, the E3/4 genotype was significantly associated with an elevated risk in individuals with T2DM and CAD. Notably, the plasma levels of low-density lipoprotein cholesterol (LDL-C) displayed marked variations across the three distinct ApoE isoforms. Moreover, patients carrying genotypes containing the ϵ4 allele exhibited lower levels of high-density lipoprotein cholesterol (HDL-C) when compared to those with the E3/E3 genotype.ConclusionsOur findings suggest an association between ApoE gene variations and the presence of both T2DM and CAD, influencing lipid profiles as well.
Which is better to predict erectile dysfunction and male sexual function in the context of metabolic syndrome: Triglyceride-Glucose Index or Visceral Adiposity Index? A Retrospective Cross-sectional Study
Authors: Bolat Mustafa Suat , Bolat Ipek , Asci Ramazan , Dundar Cihad
Published: August 2023

Background:Male sexual function is influenced by various factors, including metabolic disorders such as metabolic syndrome (MetS) and insulin resistance. We aimed to investigate the effects of two metabolic indices, the triglyceride-glucose (TyG) index and the visceral adiposity index (VAI), on erectile function and other aspects of male sexual function.
Methods: A total of 400 men having erectile and ejaculatory dysfunction were included. Age, body weight and waist circumference (WC) were calculated and comorbidities and contributing factors such as diabetes mellitus, hypertension, atherosclerotic disease, smoking, and alcohol use were recorded. Hormonal analysis was performed using the enzyme-linked immunosorbent assay (ELISA) for total testosterone, prolactin, and estradiol. The male sex-specific VAI was calculated using the [(WC/39.68)+(1.88xMI)]x(TG/1.03)x(1.31/HDL) formula. The TyG index was calculated logarithmic formula: Ln (fasting triglycerides) x (fasting glucose) / 2] (9). The participants were given the Turkish-validated 15-item long-form of the International Index of Erectile Dysfunction (IIEF) questionnaire to fill. Ejaculatory function was assessed using male sexual health questionnaire (MSHQ) consisting of four questions. The participants completed the 21-item Beck Depression Inventory. Kolmogorov-Smirnov and Chi-square tests were used for normal distribution of continuous and categorical variables, respectively. The ROC analysis was used to evaluate the predictive abilities of TyG and VAI cut-off values for ED risk. Statistical significance was set at p < 0.05.
Results: Both the TyG index and the VAI were significantly associated with ED. A higher TyG index and VAI were associated with an increased risk of ED. The presence of MetS further worsened sexual function, with lower scores in sexual satisfaction, orgasm, desire, and general satisfaction. The TyG index and VAI demonstrated similar predictive abilities for ED, as indicated by their respective area under the curve rates. Additionally, patients with MetS had poorer ejaculation quality compared to those without MetS.
Conclusions: These findings highlight the potential of the TyG index and VAI as convenient tools for predicting and assessing sexual dysfunction in men, particularly in the context of metabolic disorders. Early detection and intervention for metabolic syndrome and insulin resistance may help mitigate their negative impact on male sexual function.
Seasonal dynamics of Amblyomma cajennense (Fabricius, 1787) sensu stricto in a degraded area of the Amazon biome, with notes on Rickettsia amblyommatis infection
Authors: Araújo Flávio Eduardo Saraiva , Martins Thiago Fernandes , Ramos Carlos Celso Mendonça , Nogueira Rafael Michael Silva , Faccini João Luiz Horacio , Tavares Mariana Avelar , Lima Nicolas Jalowitzki , Bezerra Carlos Eduardo , Sousa-Paula Lucas Christian , Dantas-Torres Filipe , Krawczak Felipe Silva , Costa-Junior Livio Martins , Labruna Marcelo Bahia , DallAgnol Leonardo Teixeira , Luz Hermes Ribeiro
Published: August 2023

Background
The tick Amblyomma cajennense sensu stricto (s.s.) frequently parasitizes animals and humans in the Amazon biome, in addition to being a vector of Rickettsia amblyommatis. In the present study, we evaluated the population dynamics of A. cajennense s.s. in a degraded area of the Amazon biome, and the presence of rickettsial organisms in this tick population.
Methods
The study was carried out in a rural area of the Santa Inês municipality (altitude: 24 m), Maranhão state. Ticks were collected from the environment during 24 consecutive months, from June 2021 to May 2023. The region is characterized by two warm seasons: a rainy season from November to May, and a dry season from June to October. We characterized the temporal activity of A. cajennense s.s. on the vegetation, by examining questing activity for each life stage (larvae, nymphs, adults [males and females]), in relation to the dry and rainy season. Ticks collected in this study were randomly selected and individually tested by a TaqMan real-time PCR assay that targeted a 147-bp fragment of the rickettsial gltA gene.
Results
Overall, 1,843 (62.4%) adults (52.6% females and 47.4% males), 1,110 (37.6%) nymphs and 398 larval clusters were collected. All adult females and nymphs were morphologically identified as A. cajennense s.s. Larval activity was observed from April to December, with a peak from June to September (dry season). Nymphs peaked from September to November (transition period between dry and rainy seasons). Adult ticks were abundant from October to May (spring/summer/early autumn). The infection rate by R. amblyommatis in A. cajennense s.s. ticks were at least 7% (7/99).
Conclusion
Our data suggest a 1-year generation pattern for A. cajennense s.s., with a well-defined seasonality of larvae, nymphs and adults in the Amazon biome. Larvae predominating during the dry season, nymphs in the dry-rainy season transition and adults in the dry season. The presence of R. amblyommatis in adults suggest that animals and humans in the study region are at risks of infection by this spotted fever group rickettsial agent.
Recursive MILP algorithm to find alternate solutions in Linear Programming models
Authors: Kakkad Dev A. , Grossmann Ignacio E , Springub Bianca , Galanopoulos Christos , de Asis Leonardo Salsano , Tran Nga , Wassick John M.
Published: August 2023

The authors have requested that this preprint be removed from Research Square.
Numerical and Experimental Photoelasticity Topology Optimization
Authors: BG Avilasha , DS Ramakrishna
Published: August 2023

The photoelasticity experimental technique is developed, which extends the topology optimization method to realistic engineering design problems. The new approach enables the efficient design of complex engineering structures by allowing the designer to control the material distribution among the design areas during the optimal design process, thereby allowing the use of multiload mechanical components in a variety of applications. This study enables a novel approach to topology optimization using the photoelasticity method. The primary objective of this research is to demonstrate the viability and efficacy of using photoelasticity in topology optimization for stress-constrained design problems. The proposed methodology involves of a number of essential steps, including material selection, specimen preparation, photoelastic testing, image processing, and optimization algorithms. The integration of photoelasticity into the optimization process permits more accurate and insightful evaluations of stress distributions within structures as well as more realistic stress constraints, resulting in designs that are not only structurally efficient but also resistant to failure. The methodology presented here provides an innovative and practical approach to solving real-world engineering problems, particularly in fields where accurate stress analysis is crucial, including aerospace engineering, civil engineering, and biomechanics. The photoelasticity experimental method is demonstrated for the linking plate design problem associated with the brake drum end. The case study illustrates the potential significance of the newly developed capability for a wide variety of engineering design problems, which reduces the amount of material by 50%. This methodology expands upon conventional topology optimization techniques that rely solely on numerical simulations.
A Machine Learning Driven Computationally Efficient Horse Shoe Shaped Antenna Design for Wearable Internet of Medical Things
Authors: Khan Umhara Rasool , Sheikh Javaid A. , Junaid Aqib , Ashraf Shazia
Published: August 2023

With bio-medical wearables or sensors becoming an essential part of future generations for monitoring the health of workers and others in industrial and other environments. Computationally efficient Antenna as sensors or radiating interface being an indispensable part of such wearables. In this paper a novel Horse shoe shaped antenna (HSPA) meant for such wearables is presented in this work. Inspired by the artificial intelligence, a regression-based Machine learning (ML) techniques are used to facilitate the design of Horse shoe shaped patch antenna to predict the various on body measuring parameters. The ML models so developed are used to predict the desired responses of antenna for given physical and geometrical parameters of the design. This helps us to design an optimized antenna design while efficiently using the available resources. The optimized HSPA designed has a footprint area of 0.272λ0 x 0.224λ0 and resonates at 2.45 GHz in the frequency band of 1.9–3.05 GHz with SAR of 1.89 W/kg for an input power of 16.98 dBm, peak gain of 1.91 dBi and radiation efficiency of 62.07% when mounted on the human body. Further, a detailed comparison of the five regression-based ML algorithms is also presented and proved more efficient.
A Framework for the Optimization of Efficient Network Data Transfer using SPT Algorithm
Authors: Preet Shiv , Sharma Chirag , Bagga Amandeep , Garg Rachit
Published: August 2023

The wireless network is the engine that powers the new world's economy, and it has invaded space in the form of a satellite-powered interplanetary network. Due to signal attenuation, slowed transmission speeds, complete signal unavailability due to inclement weather, and an abundance of connected users, the wireless network's productivity must be increased as soon as possible. Another issue for IoT applications is the outdated TCP protocol, which is unsuitable for low-consumption and limited-storage IoT objects because the data buffer in these devices is negligible. The revolutionary SPT (Squeeze Pack and Transfer) method has been introduced to improve mobile network efficiency while reducing data file storage by more than 90 percent. Rather than textual symbols, binary patterns are used to compress data, resulting in a higher compression ratio and faster compression performance.
Creating safer cancer care with ethnic minority patients: A qualitative analysis of experiences of cancer service staff
Authors: Chauhan Ashfaq , Newman Bronwyn , Manias Professor Elizabeth , Joseph Ms Kathryn , Leone Desiree , Walpola Ramesh Lahiru , Seale Associate Professor Holly , Smith Associate Professor Allen Ben , Harrison Associate Professor Reema
Published: August 2023

Introduction

Effective consumer engagement practices can enhance patient safety. This is important for consumers from ethnic minority backgrounds who are exposed to increased risk of patient safety events. Using the Systems Engineering Initiative for Patient Safety (SEIPS) model, this study explored staff experiences of creating opportunities for engagement with consumers from ethnic minority backgrounds to contribute to their cancer care safety.

Method

A qualitative study was conducted using semi-structured interviews with cancer service staff from four cancer services across two states in Australia. Purposive sampling was used to recruit healthcare staff from diverse range of professions. Data was analysed using the Framework Analysis method.

Results

Fifty-four interviews were conducted with healthcare staff. Analysis of the qualitative interview data identified enablers and associated challenges that contributed to creating shared understanding between consumers and staff of the information, processes, expectations and problems arising in care. Enablers and challenges are reported in relation to four themes: (1) consumer- service provider dyad; (2) resources to support consumer engagement for safety; (3) organisational and policy levers; and (4) formal tasks incorporate consumer engagement more readily than informal interactions.

Conclusion

The availability of infrastructure and resources to support communication with consumers from ethnic minority backgrounds was limited to specific tasks across the cancer care continuum. Strategies implemented by health services to foster effective communication during formal interactions now need expansion to support and create conditions for effective consumer engagement during informal and everyday care tasks. Use of innovative language support tools and cultural considerations are required at service and system level to support consumer engagement in all type of care interactions.

Public and patient involvement

This study was embedded within a larger project that included a consumer investigator and was guided by a consumer advisory group (CAG). These consumer team members have lived experience of cancer and are from diverse ethnic backgrounds. The CAG members provided feedback on the draft interview guide and participant information for this study.
Assessment of maternal mortality rate and associated risk factors at tertiary hospitals in Burundi (2020-2021): A retrospective cohort study
Authors: Moise Miburo , Murithi Rachael Gakii , Wenjie Dai
Published: August 2023

Background:Burundi continues to struggle with maternal mortality (MM). It has been demonstrated that other variables, whether direct or indirect, contribute to the majority of maternal deaths that take place in healthcare institutions. Early risk factor identification is crucial for thorough intervention measures to be developed to prevent pregnancy-related problems.Objective:To investigate maternal mortality rate (MMR) and identify its associated risk factors among women aged 15 to 49 years at four tertiary hospitals in Burundi.Methods:We collected data describing all pregnancies from January 2020 to December 2021 among women enrolled in Centre Hospital-University of Kamenge (CHUK), Military Hospital of Kamenge (MHK), Prince Regent Charles Hospital (PRCH), and Clinical Hospital Prince Louis Rwagasore (CHPLR) referral hospitals. We reported the proportion of mothers who died per pregnancy and the MMR. Multivariate regression models were used to determine the maternal, pregnancy-related, delivery, and postpartum factors that were associated with maternal death.Results:There were 31,968 deliveries in total in CHUK, MHK, PRCH, and CHPLR referral hospitals, 125 of which resulted in maternal fatalities that could be verified. The total live births were 31,067, yielding an MMR of 402 per 100,000 live births. The mean age of women with maternal deaths was 33 years. When adjusted for study site and the other variables, our findings suggest a significant association between MMR and direct and indirect causes of maternal death, (F (8, 116) = 2.18, p < .05). There was a significant association between MMR and haemorrhage and uterine rupture, where in both cases p is less than 0.05. There was a significant association between MMR and community-level characteristics, (F (7, 117) = 9.91, p < .05). Additionally, there was a significant association between MMR and type of delay, (F (3, 121) = 2.76, p < .05). Whereas, second delay (delayed identification and arrival at the referral hospitals for treatment) was significantly associated with MMR, with p = 0.005.Conclusion:The main contributing factors to MM in 2020-2021 were haemorrhage, uterine rupture, and second delay. Reducing maternal fatalities in CHUK, MHK, PRCH, and CHPLR requires the implementation of ANC programs on the management of obstetric problems.
Analisis Nilai Moral dalam Novel Kami Bukan Jongos Berdasi Karya J. S Khairen sebagai Alternatif Bahan Ajar Sastra di SMK PGRI 3 Nganjuk
Authors: Kopsoh Nikmatul , Mulyaningtyas Rahmawati
Published: August 2023

This research is motivated by problems regarding the decline in moral values ​​that still often occur in everyday life. To be able to minimize problems regarding poor morale, especially students, namely through learning activities at school. Literary works can be used by educators to instill, shape, and develop the morale of students. One of the literary works that can be used is the novel We're Not Jongos Berdasi. This study aims to 1) describe the manifestation of the moral values ​​contained in the novel We're Not Jongos Berdasi by J.S Khairen, 2) describe the suitability of the novel We're Not Jongos Berdasi by J.S Khairen as an alternative material for teaching literature at SMK PGRI 3 Nganjuk. This study uses descriptive qualitative methods, data collection techniques are documentation and interviews. The results of this study are 1) The moral values ​​contained in the novel We're Not Jongos Berdasi are divided into three, namely the relationship between humans and God, the relationship between humans and themselves, and the relationship between humans and other humans. The moral value of man's relationship with God consists in thanking God and remembering God. The human relationship with oneself consists of self-confidence, unyielding, patient, firm, independent, and regretful. Human relations with other humans consist of caring for others, polite, honest, maintaining feelings, openness, and greeting. 2) Our novel is not Jongos Berdasi, suitable for use as an alternative literature teaching material at class XI SMK PGRI 3 Nganjuk. This is because the novel has fulfilled the aspects of language, psychology, and cultural background.
Impurity Knight shift in quantum dot Josephson junctions
Authors: Pavešić Luka , Pita Vidal Marta , Bargerbos Arno , Žitko Rok
Published: August 2023

Spectroscopy of a Josephson junction device with an embedded quantum dot reveals the presence of a contribution to level splitting in external magnetic field that is proportional to \cos\phicosϕ, where \phiϕ is the gauge-invariant phase difference across the junction. To elucidate the origin of this unanticipated effect, we systematically study the Zeeman splitting of spinful subgap states in the superconducting Anderson impurity model. The magnitude of the splitting is renormalized by the exchange interaction between the local moment and the continuum of Bogoliubov quasiparticles in a variant of the Knight shift phenomenon. The leading term in the shift is linear in the hybridisation strength \GammaΓ (quadratic in electron hopping), while the subleading term is quadratic in \GammaΓ (quartic in electron hopping) and depends on \phiϕ due to spin-polarization-dependent corrections to the Josephson energy of the device. The amplitude of the \phiϕ-dependent part is largest for experimentally relevant parameters beyond the perturbative regime where it is investigated using numerical renormalization group calculations. Such magnetic-field-tunable coupling between the quantum dot spin and the Josephson current could find wide use in superconducting spintronics.
Bilingualism in Kurdish and Turkish and Its Semantical Result in Turkish
Authors: GEYİK Resul , ÇELEBİ Sedat
Published: August 2023

The aim of this study is to determine how bilingual people understand two languages and to see the influence of bilingualism in different situations from a semantic viewpoint. By way of example, sentences are chosen from the daily communication and dialogues of Kurdish and Turkish speakers—not from written texts. In the case of Kurdish, the speakers will probably be uneducated in their mother tongue, whereas their education in Turkish will be what they are taught through the curriculum in Turkish schools, where Kurdish is offered as an elective subject in competition with the Arabic of elective religious subjects. The intention is to scrutinize the mutual influence of Kurdish and Turkish and to understand and explain how one and the same person processes thoughts in one language to another. Observing and classifying in a way as to bring out thought patterns between the two languages should shape how they transfer or translate on a regular basis, whether cognitively or non-cognitively.
Biosorptive removal of selected metal ions from simulated wastewater using highly metal-resistant bacteria
Authors: Hussain Ali , Hasan Ali , Sherzada Shahid , Noor Tahir , Ahmad Shehzad , Kaoma Mwansa , Elsehly Emad M.
Published: August 2023

In the current scenario of the need for cost-effective remediation, our study aimed to assess the remedial potential of bacteria obtained from metal-rich wastewater. To simulate the conditions, we prepared wastewater containing five toxic metals (Cu, Cr, Ni, Fe, and Pb). Two types of metal-resistant bacteria were isolated from a prominent wastewater drain in Lahore, Pakistan. These isolated bacteria were thoroughly characterized, both phenotypically and genotypically. Subsequently, the isolated bacteria were exposed to the wastewater solution containing each of the aforementioned metals at a concentration of 250 ppm. The exposed isolates were then incubated for a duration of 15 days. After 5 days, we measured the uptake of metals by the bacterial isolates. Following the 15-day incubation period, we observed that the bacterial isolates demonstrated the maximum efficiency in removing metals, with approximately 47.5% of Fe, 77% of Ni, 75.75% of Cu, 64% of Cr, and 82.5% of Pb being removed. These findings have significant implications for the development of environmentally friendly and cost-effective strategies for metal ion remediation.
Sobre la definición de contrato aleatorio y sus implicancias legales
Authors: Vásquez Rebaza Walter
Published: August 2023

El presente artículo tiene como propósito principal esclarecer el concepto de contrato aleatorio en el marco del sistema legal peruano, así como puntualizar algunas de las principales consecuencias jurídicas de dicha categoría. A tales fines, se hará hincapié en ciertas nociones relevantes, tales como la noción de riesgo y alea normal. Este artículo analiza también la dispersa regulación del Código Civil que alude al contrato aleatorio.
Algunas consideraciones sobre el riesgo permitido en el derecho penal
Authors: Caro John José Antonio
Published: August 2023

El presente trabajo emplea como criterio el riesgo permitido utilizado en el ámbito de la imputación objetiva. El análisis de este escrito, además de ser dogmático, incluye jurisprudencia a fin de llevar a la práctica las hipótesis señaladas.
Experimental Determination of the Mechanical Properties of Onyx Material
Authors: ČUCHOR D.
Published: August 2023

Abstract. The main objective of the study is to determine the mechanical properties of the composite material produced by 3D printing. Experimental verification of the influence of the orientation and thickness of the layers was carried out. The test specimens for the experiment are fabricated by 3D printing from Onyx material using the Fused filament fabrication (FFF) method. The investigation of the mechanical properties is carried out using static tensile testing on the Inova FU-O-160-1260-V1 machine. The shape and dimensions of the test specimens are defined by the ASTM D638-14 standard. The study aims to determine the mechanical properties of Onyx material and specify the influence of the orientation of the layers and the thickness of the specimens on these mechanical properties.
High-Temperature Oxidation of High-Entropy FeNiCoCrAl Alloys
Authors: GUMEN O.
Published: August 2023

Abstract. Phase composition and mechanical properties and the formation of oxide layers on Fe40-xNiCoCrAlx (x = 5 and 10 at.%) alloys in long-term oxidation at 900 and 1000°C were studied. In the initial cast state, depending on the aluminum content and valence electron concentration, the alloys contain only an fcc solid solution (VEC = 8 e/a) or a mixture of fcc and bcc phases (VEC = 7.75 e/a). Thin continuous oxide scales containing Cr2O3 and NiCr2O spinel formed on the surface of both alloys oxidized at 900°C for 50 h. A further increase in the annealing time to 100 h leads to the formation of aluminum oxide Al2O3 in the scale on the Fe30Ni25Co15Cr20Al10 alloy, having high protective properties. An increase in the oxidation temperature to 1000°C results in partial failure of the protective layer on the alloy with 10 at.% Al. Long-term holding at 900°C (100 h) + 1000°C (50 h) does not change the phase composition of the Fe35Ni25Co15Cr20Al5 alloy matrix, being indicative of its high thermal stability. In the two-phase Fe30Ni25Co15Cr20Al10 alloy, the quantitative ratio of solid solutions sharply changes: the amount of the bcc phase increases from 4 to 54 wt.% and its B2-type ordering is observed. The mechanical characteristics of the starting alloys and those after long-term high-temperature annealing were determined by automated indentation. The hardness (HIT) and elastic modulus (E) of the cast Fe35Ni25Co15Cr20Al5 alloy are equal to 2 and 147 GPa, respectively, and decrease to 1.8 and 106 GPa after a series of long-term annealing operations. The Fe30Ni25Co15Cr20Al10 alloy shows the opposite dependence: HIT increases from 2.5 in the initial state to 3.1 GPa after annealing and E decreases from 152 to 134 GPa. This indicates that the Fe30Ni25Co15Cr20Al10 alloy is promising as a high-temperature oxidation-resistant and creep-resistant material. Introduction
Geometrical Accuracy of Flexspline Prototypes Made by FDM/MEM Methods
Authors: PACANA J.
Published: August 2023

Abstract. This article presents an analysis of the geometrical accuracy of flexspline prototypes that were a component of harmonic drive. To produce the test models, a MEM (Melting and Extrusion Modeling) method was used. This additive method allows the production of elements with very complicated shapes from various polymeric materials. As the test model, a flexspline made of ABS (acrylonitrile-butadiene-styrene) was assumed. Such a special gear with a complicated construction was chosen, because its unique design allows one to obtain clear conclusions from the analysis. To expand the scope of research, models of flexspline with four different construction solutions were made and tested. As a step of the analysis, contact measurements were performed for several flexspline models on the coordinate measuring machine to check their dimensions. The verification of the geometrical accuracy of flexspline models will allow to assess the usefulness of additive methods for the production of prototypes and finished products.
Comparing Qualitative Raster Maps
Authors: WIECZOREK M.
Published: August 2023

Abstract. Spatial diversity of the natural environment can be presented using raster qualitative data. They can be the result of collecting field data or be the result of stochastic modelling of a certain complexity of the environment. One example of such modelling is the determination of similar elements of relief forms on the basis of morphometric variables. The use of unsupervised methods for clustering raster data in modelling can produce different maps. It is necessary to assess the compatibility of the obtained maps in order to assess how significant the differences between them are. The article presents selected stochastic and deterministic methods for assessing the spatial distribution of data. Exemplary methods of measuring variability at the global and local level were discussed.
Evaluation of Safe and Hygienic Work Conditions in the COVID-19 Era: A Case Study in a Production Company
Authors: KIELESIŃSKA A.
Published: August 2023

Abstract. In recent times, the importance of occupational health and safety has escalated for modern enterprises. This shift can be attributed to the emergence of the COVID-19 virus, which compelled numerous businesses to adopt crisis management strategies and embrace remote work arrangements. It can be argued that the pandemic necessitated employers to implement suitable health and safety measures in order to sustain their operations in the labor market. The objective of this study is to evaluate occupational risks, considering the implications arising from the pandemic, and subsequently assess the provision of safe and hygienic conditions during this period. It is important to note that workplace hygiene requirements can vary based on the company, industry, and job role. Different work environments will entail distinct hygiene demands, and certain occupations or industries may even entail additional risks warranting extra protection. Hence, the assessment focused solely on production positions such as machine operators, fitters, quality inspectors, and warehouse workers.
How to Enhance the Management and Quality of Electronic Publications?
Authors: HRABOVSKYI Y.
Published: August 2023

Abstract. The electronic publication format has become valuable and easy to access for a modern person. Many readers prefer electronic publications to print ones. Publication houses that want to access more customers and enhance their sales should consider including electronic formats in their product offers. Managing a publishing company requires constant modification and diversification of products. To a large extent, the offer of publications in electronic format has a chance to attract more customers than the traditional printed form. It is primarily about easy access to the searched reading items. The customers can purchase the publication in various electronic formats, e.g., PDF, MOBI, or ePUB format, according to their needs. It does not require going to the library, reading room, stationery store, or waiting for the parcel at the place of residence. The purchased product, paid or free, immediately becomes available after downloading to the appropriate device. It is a very convenient and quick way to get to publications. Therefore, publishing houses should keep up with the times and offer publications in electronic format. However, a number of factors must be taken into account before such a product is created. Often, there is a need to convert the print version of publications into electronic format - a need to convert documents on formats of computer editorial systems in electronic formats. In the paper, the method of changing the orientation of the page of the elevation publication is proposed. Then a set of parameters of the arrangement elements is developed. The algorithm for the automatic change of page orientation of the viewing edition is created. Based on this algorithm, tools have been developed to automatically change the edition page as an appropriate prototype of automation tools (Adobe, USA product) in HTML format using JavaScript programming language (Japan). For the qualitative work of the prototype, the basic rules of the set and layout were analyzed. The designed complex of typical page layouts, in terms of laying elements on the page. An orientation change algorithm with its restrictions has been developed for each typical layout.