bluuebunny/crossref_metadata_2025 huggingface dataset:
Can Preoperative Axillary Ultrasound and Biopsy of Suspicious Lymph Nodes Be An Alternative To Sentinel Lymph Node Biopsy in Clinical Node Negative Early Breast Cancer?
Authors: Ozler İsmail , Aydin Hale , Guler Onur Can , Bostancı Işıl Esen , Güner Bahar Şahin , Karaman Niyazi , Doğan Lütfi , Özaslan Cihangir
Published: January 2021

Aim: The aim of this study was to assess the efficacy of pre-operative
axillary ultrasonography (AUS) and pre-operative axillary fine-needle
aspiration biopsy (FNAB) from suspicious lymph nodes in clinically
node-negative breast cancer to compare with radiologically positive and
sentinel lymph node biopsy (SLNB) positive involvement. Method:
Clinically node-negative early-stage breast cancer patients were
included in the study. These patients under went pre-operative AUS
examination, suspicious lymph nodes were evaluated with FNAB. AUS-FNAB
results were compared with those of SLNB or of axillary dissection.
Results: Of 181 patients undergoing AUS, 32 were reported to have
axillary metastasis, 25 suspicious and 124 benign nodes. The suspicious
group underwent FNAB examination and metastasis was found in 9 of them.
The sensitivity of AUS-FNAB was found to be 64.06%, specificity 100%,
positive predictive value 100% and negative predictive value (NPV)
83.5%. False negativity rate (FN) of this method was 16,4%.
Lymphovascular invasion and tumor size were found statistically
significant factors for false negativity. Conclusion:It was concluded
that axillary AUS-FNAB with its high NPV, low FN rate, may be a clinical
alternative to SLNB for early stage breast cancer patients.
Natural And Human-Induced Land Degradation And Its Impact Using Geospatial Approach In The Kallar Watershed Of Tamil Nadu, India
Authors: Rahaman S. Abdul , Solavagounder Aruchamy
Published: January 2021

Land degradation is human-induced and natural process that adversely affects the land, to function effectively within a complex ecosystem. In recent years, the Kallar watershed has encountered various kinds of multifarious problems on both land and water in the urban and its environs. The upper part of the study area is facing water scarcity problems in the past few years, but which included no such rare occurrences in the past. The mid-portion in the vicinity of foothills are highly affected by soil erosion, whereas the lower portion of the area has faced problems like land degradation, such as an unusual increase of wastelands and conversion of good agriculture lands into construction plots. Apart from these, the study area is frequently affected by nature induced disasters like a landslide, forest fire, flooding, and drought. In this complex situation, the qualitative assessment of human-induced land degradation and its impact is essential. For this, Geospatialbased Multi-Criteria Evaluation (MCE) as a multidisciplinary approach has been adopted. To assess land degradation, six major criterions are preferred such as terrain (slope, elevation), environment (landuse/land cover, NDVI), soil erosion, and demography (population density). Considerable weights and ranks were assigned through an empirical MCE method. Based on the criteria, the land degradation was carefully delineated into five significant categories such as low (38.3%), moderately (23.6%), marginally (15.4%), highly (4.8%), and severely degraded (17.8%). The depletion of vegetation cover on hilly terrain and subsequent cultivation without proper protection measures constitute the possible reason for severe soil erosion and land degradation.
Features of urban public spaces in the context of globalization
Authors: Khomyakova K. L.
Published: January 2021

The article deals with characteristics of urban public spaces, their role in the global transformation of the social relations system is determined. The ambiguity of assessing the impact of globalization on modern cities is due to the theoretical and methodological problems of modern sociological urbanism. There is no single approach among scientists to defining the concept of urban public space, which determines the relevance of the study of its interpretation and definition of essential properties. Public spaces are considered as a connecting element between the system and social levels of urban research, which correspond to the levels of integration identified by the modern sociologist E. Giddens. The article analyzes classical and modern approaches to the study of public space, there is reveals the course of evolution of sociological thought in relation to the formation of differentiation of types of spaces within cities. Based on the analysis of the works of modern sociologists and urbanists, such key features of public spaces as openness, socio-political neutrality, and symbolism were identified. Global processes and contradictions lead to an aggravation of the problem of the presence of the category of “Others” within public urban spaces, which are representatives of various segments of the population, with a variety of claims and interests. One of the consequences of the intensive development of digital technologies is a possible situation of “competition for the citizen” between traditional public spaces and online services. Assumptions are made about future transformations of social relations within public spaces as a result of the impact of the COVID-19 coronavirus pandemic.
Life on display: why it is important to expose your actions on the social network
Authors: Starchenko A. E. , Semina M. V.
Published: January 2021

Social networks have emerged relatively recently in human life, but have already become an integral part of it. Companies tell about themselves, their activities, innovations, promotions and events in their profiles. This helps increase audience coverage, tell more about your brand, products, services. People in personal accounts have the opportunity to share their lives and creativity through photos, videos and texts. Now it is not necessary to receive higher education to become an operator, director or actor whose talent is recognized by society. It is enough to start a page on the social network and start sharing your knowledge and creativity.To find out why people post photos, videos and write texts on their social networks, a pilot sociological study was carried out. The method of deep interview with active users of social networks was chosen to carry out the study. The interview allowed getting unique information, to learn the opinion of users about social networks, the impact of the new way of communication on their life, to identify the reasons why users start and maintain profiles.The respondents were 20 users of social networks between the ages of 19 and 22. Interviewees have profiles on the most popular Instagram and Vkontakte networks. As a result of the analysis of the interview, a tendency was revealed to differ in the perception of users of their actions on the social network and similar actions of other users. Their content is perceived by them as opportunities to be in sight, as a resource to form their social status and an element of influence on their reference group. And the same content published by others is perceived as boasting.
Evaluation of the safety and usefulness of citrus jabara fruit peel powder cream for patients with atopic dermatitis
Authors: Inaba Yutaka , Furukawa Fukumi , Azuma Seisho , Baba Kimiye , Taniguchi Masahiko , Murakami Yoshinobu
Published: January 2021

Citrus jabara (CJ) is a rare citrus that originally grew wild only in the southern area of the Kii peninsula in Japan. In the relationship between CJ and atopic dermatitis (AD), improvement of AD by oral intake of CJ fruit juice was reported in AD model mice. Our previous study also showed anti-inflammatory potentials of CJ fruit peels in vitro. In this study, the applicability of CJ fruit peel powder (CJ powder) for topical application in patients with AD was investigated. After confirming both the safety of CJ powder in preclinical studies and the safety of 5% CJ powder cream in healthy volunteers, the safety and usefulness of 5% CJ powder cream were evaluated in 20 patients with AD. Evaluation of 5% CJ powder cream in patients with AD for 4 weeks showed improvement in the mean severity score of the affected area (from 3.0 to 2.0, p=0.001 by Student’s t test), improvement in skin lesions (11 of 20 participants), usefulness (16 of 20 participants), and safety (16 of 20 participants). Although aggravation of symptoms on application areas were observed on 4 participants, their aggravation were systemic, resulting from causes other than tested cream. These results suggested that 5% CJ powder cream is useful and safe for patients with AD.
A Case of Covid-19 Patient Presenting with Gastrointestinal-Specific Symptoms in Indonesia
Authors: Simadibrata Daniel Martin , Rumende Cleopas Martin , Mulyadi Rahmad , Simadibrata Marcellus
Published: January 2021

Coronavirus disease 2019 (COVID-19) is an emerging infectious disease officially declared as a pandemic on 11 March 2020 by the World Health Organization (WHO). Indonesia’s COVID-19 case fatality rate remain consistently high, approximately twice the global case fatality rate available. Patients typically present with fever, dry cough and dyspnea. However, there were reports of atypical COVID-19 symptoms such as myalgia, fatigue, diarrhea, nausea, and vomiting. These atypical presentations were suggested to indicate a more severe COVID-19. Here, we present a case of COVID-19 patient presenting with gastrointestinal-specific symptoms in Indonesia.
Liver Metastasis of Malignant Pilomatrixoma: Devastating Outcome from A Possibly Under-Treated Case
Authors: Dameria Flora , Stephanie Marini , Krisnuhoni Ening , Handjari Diah Rini , Rahadiani Nur
Published: January 2021

Malignant of pilomatrixoma, known as pilomatrix carcinoma, is a rare cutaneous adnexal tumor that derives from hair matrix cells.The tumor usually occurs in male, with the predominant age range between 40 to 60 years old, located in the head and neck area. The tumor consisted of atypical basaloid cells aggregation, ghost cells, and keratinous material. We report a case of 54 years old male patient referred to Cipto Mangunkusumo Hospital Jakarta with a mass in his right upper quadrant abdomen and a lump in the axilla. The magnitude resonance imaging (MRI) and positron emission tomography (PET)-scan revealed metastatic lesions in several lymph nodes and internal organs. The patient underwent liver biopsy which showed that tumor was composed of atypical basaloid cells, amyloid-like material, keratin mass, and was diagnosed as pilomatrix carcinoma. This case is being reported due to its rarity, potential pitfalls due to histologic similarity with several other entities, and to show the importance of histopathology examination in patient’s treatment to prevent a devastating outcome.
Characteristics of Non-Alcoholic Fatty Liver Disease Patients at Dr. M. Djamil General Hospital Padang
Authors: Yetti Husna , Prahastiwi Nada Utami , Susanti Restu , Decroli Eva , Miro Saptino
Published: January 2021

Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is emerging as chronic liver disease, both in developed and developing countries. NAFLD affects up to 25% population worldwide. The incidence of NAFLD associated with various risk factors supporting the development of the fatty liver. This study aim is to know the characteristics of NAFLD patients.Method: Retrospective study was conducted from medical records to find the characteristics of patients diagnosed with NAFLD  at Dr. M. Djamil General Hospital from January 2016 – December 2018.Results: Seventy-seven patients were diagnosed with NAFLD. The majority of  NAFLD patients were male and female at 36-45 years old and female at 65 years old. Unemployed females were more prevalent compared to males. Dyslipidemia was the most component of a metabolic syndrome found in NAFLD patients. From laboratory findings, 55.56% of patients have increased aspartate aminotransferase (AST) levels, while 52.78%  have increased alanine aminotransferase (ALT) levels. Ultrasonography used widely as a diagnostic device to detect NAFLD. Pharmacological therapy based on American Asociation for the Study of Liver Disease (AASLD) recommendation that used widely to treat patients with NAFLD was statin.Conclusion: The incidence of NAFLD was found to vary in different age ranges and sexes. Dyslipidemia occurred in most of NAFLD patients. AST and ALT levels increased in about half of the patients. Abdomen ultrasound as a diagnostic modality that was widely used.
Jak uczyć (się) języka ojczystego, czyli szkolne interakcje z językiem (czeskim)
Authors: Niesporek-Szamburska Bernadeta
Published: January 2021

The author describes an innovative project of teaching/ learning the native language (Czech), emphasizing modern features of the concept, such as: the use of constructivist indications; text-centricity; student activation; respect for their communication needs; application of the criterion of usefulness of acquired skills in the extracurricular life of students; basing the educational process on students’ preconcepts, introducing language learning into a function- al and communicative framework. The author also points to the observance of the language teaching principles that determine the concept, such as: complexity; the relationship between the student’s cognitive and linguistic development, including basing of teaching on a three- -phase model of learning and teaching which uses a constructivist framework of learning (evocation – awareness of meaning – reflection (evokace – uvědomění si významu – reflexe: E-U-R). The further principles are: orientation on learner and the principle of topicality of linguistic knowledge. All of them condition the appropriate innovative concept of language acquisition as a fresh and effective proposal – ready for implementation.
An efficient protocol for mass multiplication of Centella asiatica (L.) Urban and determination of its phenolic content
Authors: Kumari Shweta , Trivedi Maheshwar Prasad
Published: January 2021

The present study was focused on standardizing a protocol for callus induction as well as regeneration in Centella asiatica from leaf and stem as explants. Stem and leaf explants have been inoculated in B5 media supplemented with BAP (0.1-2.5 mg/l), kn (01-04 mg/l) and NAA (0.1-0.5 mg/l), 2, 4-D (0.2mg/l) for callus induction. The combination of BAP and NAA leads to the formation of green, brown, compact and friable calli while Kn and 2, 4-D induced brown calli. Highest shooting was obtained from BAP (1.5 mg/l) and NAA(0.5 mg/l).When the shoots were inoculated in half strength of B5 media fortified with 0.1 mg/l BAP and 0.5 mg/l NAA showed cent percent rooting with the highest number of roots per shoot (11.05 cm) and maximum root length (1.86 cm). Stem showed the best explants for callus induction as compared to leaf explants. A low concentration of plant growth regulators was unable to induced callus response in leaf and stem explants. Phenolic content analysis showed that calluses contain more amounts of phenol (0.81 mg/gmdw) as compared to both leaf (0.63 mg/gmdw) and stem (0.59 mg/gmdw) explants.
Ketamine’s Role in Spirituality: How One Synthetic Drug Catalyzes a Natural Experience
Authors: Woods Samiah
Published: January 2021

This article highlights the potential spiritual effects of a popular anesthetic, ketamine, and how these spiritual effects can be used to help promote the reconciliation of spiritual and physical health. Ketamine, like the prominent psychedelic, psilocybin, has reportedly caused feelings of spiritual revelation and “out of body experiences” that many physicians may not feel qualified to discuss with their patients. This reluctance to address ketamine-induced spiritual experiences may affect the health outcomes of the patient. The primary goal of this project is to bring academic validity to considerations of the spiritual health of patients. This paper (1) investigates the extent that ketamine-induced, non-ordinary experiences can help bring awareness to the compatibility of spiritual and physical health and (2) compares the mechanisms of ketamine and psilocybin, as well as their value to the medical community due to the spiritual experiences that they catalyze. Thus, this research seeks to demonstrate that understanding the spiritual value of ketamine may encourage better communication between the physician and patient and promote more holistic healthcare approaches.
La práctica educativa bajo el lente de la teoría de la actividad
Authors: De-Vincenzi Ariana , Marcano-Gurgullón Dairaliz , Macri Alejandra
Published: January 2021

Se realizó un estudio de caso para analizar la configuración de buenas prácticas educativas en una universidad privada argentina, mediante la observación de clases y entrevistas con profesores y estudiantes. Sustentado en la Teoría dela Actividad y en el enfoque ecológico de la práctica educativa en el sistema áulico que configura una práctica educativa de calidad, estudiantes y docentes se involucran en un proceso formativo caracterizado por el intercambio sociocultural de expectativas, experiencias, actitudes y conocimientos en torno a un objeto consensuado, que es transformado mediante sus interacciones en un producto que evidencia los resultados del aprendizaje. Las mediaciones socioculturales–físicas y simbólicas– entretejen en la construcción de una comunidad con reglas y división de trabajo claramente establecidas. La horizontalidad de la retroalimentación entre estudiantes en instancias de revisión y corrección de los trabajos evidencia el aprendizaje colaborativo.
Caracterización de la gerencia en la deserción estudiantil en instituciones de educación superior del Atlántico, Colombia
Authors: Gutiérrez-Echeverría Rocío
Published: January 2021

El estudio tiene como propósito caracterizar la gerencia en la deserción estudiantil en instituciones de educación superior del sector privado de la ciudad de Barranquilla, Departamento del Atlántico – Colombia. Se estructuró con base en categorías y subcategorías que describen elementos importantes que abordan la temática gerencial y el fenómeno de la deserción estudiantil. Esta investigación se realizó bajo el paradigma epistemológico cualitativo, específicamente con el método fenomenológico, se aplicó un guion de entrevista con ciertos requisitos para la selección de los dicientes entrevistados, los cuales fueron tres sujetos con cargo de coordinador académico en las sedes de la Universidad Simón Bolívar de Barranquilla. En cuanto a la  técnica de análisis de datos se utilizó la categorización axial que permite la codificación y categorización selecta mediante los procesos de integración y refinamiento de las categorías para explicar lo hallazgos del fenómeno, por consiguiente se teorizan los aportes y recomendaciones. Los resultados evidencian las deficientes competencias en habilidades gerenciales ante el problema de la deserción estudiantil; siendo los factores del mismo determinados por aspectos individuales, socioeconómicos, académicos e institucionales; y finalmente tipificarla por cohorte, período y ausencia intersemestral; por lo que se concluye que  los hallazgos se ubican dentro de los postulados teóricos y referenciales, por tratarse de directrices emanadas por el Ministerio de Educación Nacional de Colombia.
Autoeficacia y su asociación con la autoestima, motivación intrínseca y nivel educativo de la madre en estudiantes universitarios
Authors: Fong-Silva Waldyr , Fong-Amarís Wendy , Colpas-Castillo Fredy
Published: January 2021

La presente investigación permitió realizar un estudio de relación entre la Autoeficacia y la autoestima, motivación intrínseca y nivel educativo de la madre en estudiantes universitarios de ingeniería de la Universidad de Cartagena. La muestra estuvo compuesta por mil doscientos (1200) estudiantes entre 2016 y 2018. El instrumento utilizado para medir la Autoeficacia fue la Escala de Autoeficacia General creada por Baessler y Schwarcer (1996), para la autoestima se empleó la Escala de Autoestima de Rosenberg (1995), para la motivación intrínseca se empleó el "Inventario de autorregulación del aprendizaje" diseñado por Lindner, Harris y Gordon (1993) y para el nivel educativo de la madre se utilizó la encuesta. Al cruzar la variable dependiente Autoeficacia con las independientes autoestima, motivación intrínseca y nivel educativo de la madre se pudo realizar el diagrama de barras de correlación arrojando significancia estadística entre la autoeficacia con la motivación intrínseca y el nivel educativo de la madre a un nivel de confianza del 95% mientras que con la autoestima no arrojó significancia alguna.
Fabricación de hidrogeles entrecruzados de carboximetil celulosa-SiO2: Composición y estabilidad térmica hacia aplicaciones biomédicas
Authors: Patiño-Ruiz David
Published: January 2021

Nuevos e innovadores materiales para aplicaciones biomédicas y farmacéuticas deben considerar factores como la composición y estabilidad térmica para establecer las propiedades fisicoquímicas adecuadas para sistemas eficientes de liberación controlada de fármacos. En este estudio, hidrogeles de carboximetilcelulosa (CMC) son preparados incorporando nanopartículas de dióxido de sílice (SiO2) previamente modificadas con grupos de aminas primarias (-NH2), buscando evaluar la composición química y mejorar la estabilidad térmica. El método de carbodiimidas es utilizado para promover el entrecruzamiento de la CMC con la formación de enlaces amidas de grupos carboxilo (C=O) activados y su posterior enlace con grupos -NH2. La información morfológica muestra nanopartículas de SiO2 dispersas con superficie lisa, forma regular, y diámetro promedio de 104 nm. La composición del material y la estabilidad térmica son evaluadas mediante espectroscopia infrarroja de la transformada de Fourier y análisis termogravimétrico para establecer una perspectiva preliminar de hidrogeles funcionales para aplicaciones biomédicas y farmacéuticas. La formación de enlaces amidas es confirmado indicando entrecruzamiento exitoso de la estructura de la CMC con nanopartículas de SiO2-NH2, atribuido a la activación de los grupos C=O y su fuerte afinidad a los grupos -NH2. Esta interacción mejoró la estabilidad térmica de los hidrogeles entrecruzados de CMC-SiO2 hasta 469°C siendo el último evento de descomposición, resaltando la contribución de una mayor presencia de nanopartículas de SiO2-NH2. Estos resultados sugieren un adecuado proceso de fabricación de hidrogeles entrecruzados de CMC-SiO2 como material novedoso con propiedades fisicoquímicas prometedoras, contribuyendo en estos campos en sistemas de administración controlada de fármacos.
Modelado del registro automatizado de la gestión docente para una institución universitaria
Authors: Geizzelez-Luzardo María
Published: January 2021

El propósito de este trabajo consiste en diseñar una base de datos para un sistema automatizado de gestión docente, tomando como referencia las experiencias en la Escuela de Nutrición y Dietética de LUZ, a fin de automatizar los procesos relacionados con el registro e inspección de cada una de las actividades docentes que se ejecutan dentro de esta instancia universitaria. Para ello se empleó el método de Ciclo de Vida para el Desarrollo de Sistemas propuesto por los autores Kendall y Kendall (2011) hasta la fase de Diseño. Para la recolección de datos se utilizó la observación directa con la finalidad de definir los requerimientos que debía cubrir el sistema, así mismo se evidenció que el proceso de registro de actividades docentes no alcanzaba las expectativas demandadas, puesto que éstas se realizan de forma manual lo que genera pérdida de tiempo y errores de cálculo en el suministro de la información, por lo cual se llegó a la conclusión de automatizar dicho proceso mediante un sistema de información que proporcione soluciones inmediatas a los requerimientos relacionados con el proceso de gestión docente de la institución, a fin de manejar con mayor confiabilidad y eficacia toda la información a procesar por el mismo.
Profile of circulating MicroRNAs in low density lipoprotein uptake: literature review
Authors: Santos Maria Elisabete Silva , Paraense Ricardo Sousa de Oliveira , Fonseca Ricardo Roberto de Souza , Pereira Danilo Leôncio Aguiar , Cordeiro Carlos Eduardo Silva , Corrêa Thaís Letícia dos Santos , Imbiriba Luciana Carvalho , Feio Patrícia do Socorro Queiroz , De Amorim Emília Maria Paiva , Alves Erik Artur Cortinhas
Published: January 2021

Objective: Delineate a profile of circulating miRNA that interfere with the uptake of c-LDL through the regulation of LDL, APOB-100 and PCSK9 genes that can be used as biomarkers for prognosis and treatment of atherosclerosis. Bibliography review: The atherosclerosis, a chronic and inflammatory disease that occurs when there are high levels of LDL on plasma. This important risk factor for development of cardiovascular disease is the main cause of death worldwide. The miRNAs have recently emerged as potential biomarkers and therapeutic target for lipid metabolism disorders. In this review, we will provide profile of circulating miRNAs that have demonstrated being regulators of PCSK9, LDL and APOB100 genes. Recent work has identified the miR-148, miR-128, miR-27a/b, miR-185, miR-301, miR-130 as important regulators of this pathway because they decrease supply of LDL receptors through interaction with PCSK9. Final considerations: We conclude that, when overexpressed, miR-148a, mir128 and miR-27a/b, miR-122 and miR-34 are related to decrease in LDL, facilitating occurrence of atherosclerosis. Detection of miRNAs profile could be used in the future as a biomarker for disturbs linked to c-LDL uptake and in future anti-miRNAs therapies may be used in the treatment of atherosclerosis.
Efeitos adversos dos medicamentos antiparkisonianos e sua influência na qualidade de vida dos pacientes
Authors: Da Rocha Iane Lopes , Nogueira Emanuella de Castro Negreiros , Da Cunha Daniele Cavalcante Medeiros , Guerra Bruno Mendes Moura Dias , Nogueira Jackeline Dias Cunha , Almeida Andrey Sady de Sousa , Arouca Kalliny Luiza Dias , Da Rocha Thaiz Helena Lopes , De Araujo Alyne Rodrigues , Barros Mário Abel Lima
Published: January 2021

Objetivo: Avaliar aspectos relacionados à saúde mental e física do paciente com Parkinson e o impacto dos efeitos adversos do tratamento medicamentoso na qualidade vida. Métodos: Foi realizado um estudo transversal, não experimental e descritivo de abordagem quantitativa que utilizará como instrumento de pesquisa a escala unificada de avaliação da Doença de Parkinson (Unified Parkinsons´ disease Rating Scale – UPDRS-ADAPTADA), com assinatura prévia dos pacientes e/ou responsável do Termo de Consentimento Livre e Esclarecido. Resultados: A amostra foi constituída por 20 pacientes acometidos pela doença de Parkinson e em uso de medicações antiparkinsonianas. Em geral, estes pacientes sentem-se tristes, mas não são diagnosticados com depressão e não possuem pensamentos suicidas. Em relação ao cotidiano, eles percebem uma lentidão, no entanto não se sentem incapazes e a maioria consegue realizar as tarefas diárias sem ajuda. Dor nas discinesias e distonias são os efeitos colaterais mais relatados pelos pacientes entrevistados. Conclusão: A partir desse estudo foi possível observar que o tratamento farmacológico pode contribuir para melhoria da qualidade de vida dos entrevistados e que os resultados encontrados corroboram com estudos já publicados sobre pacientes de outras regiões.
Identification of Bioisosteric Scaffolds using Scaffold Keys
Authors: Ertl Peter
Published: January 2021

Replacement of a central scaffold in a bioactive molecule by another scaffold with similar structural features (a procedure called sometimes "scaffold hopping") is a classical medicinal chemistry technique used to improve molecular properties and explore novel interesting areas of chemical space. The new scaffolds may be identified by database mining, match in physicochemical properties and often just by applying medicinal chemistry knowledge. In this study a novel method to find bioisosteric scaffolds is described when these are identified using similarity in simple substructure features called Scaffold Keys. Performance of the method is illustrated on several examples and a freely-available web tool https://bit.ly/scaffoldkeys allowing to find bioisosteric scaffold analogs is introduced.
Invivo Pharmacokientic and Pharamacodynamic Studies of Optimized Antihyperlipidemic Drug Loaded Solid Lipid Nanoparticle
Authors: Gannimani Veerabhadra Rao  , Gadela Venkata Radha  , Krishnaji Rao M  , Brito Raj S  , Bhaskar Reddy K
Published: January 2021

The purpose of this research is to increase bioavailability by solid lipid nanoparticle (SLN) carrier for low bioavailable drugs (< 5%) such as Lovastatin. Eight SLN loaded Lovastatin was designed and optimised by variables such as Particle Size (PS in nm) and Zeta Potential (ZP in mV) using a micro emulsification technique. SLN 7 was chosen as the optimised formulation according to the findings obtained and the same was chosen for invivo pharmacokinetic and triton-induced antihyperlipidemic operation. SLN7 confirms an improvement in bioavailability of 3.15 percent by an improvement in AUC compared to conventional dosage type (Altoprev) from the pharmacokinetic invivo results. SLN was also an appropriate career in drug delivery for Lovastatin by enhancing bioavailability and therapeutic response. The stability studies of SLN7 revealed that the evaluation parameters of SLN did not change significantly. It was verified from the data that the drug-loaded SLN was stable under varying temperature and humidity conditions. While compare to 25˚c±2˚c/ 60% RH, SLN are more stable in 4˚c±2˚c  and shows good reproducible reports in Particle Size (nm), Zeta potential (mV), PI and EE% data. Therefore, Solid Lipid Nanoparticle is a viable drug carrier mechanism for low bioavailable Lovastatin to improve their bioavailability through efficiently permeating them.
THE INFLUENCE OF PROJECT MANAGER’S MOTIVATION ON PROJECT SUCCESS THROUGH DEVELOPING TRUST AND KNOWLEDGE SHARIN
Authors: Nawaz Javeria , Shahab Hammad , Ziaullah Muhammad , Raza Hassan , Sardar Muhammad Usman
Published: January 2021

The quantity for the project is expanding crosswise over numerous divisions and the related difficulties are substantial. Utilizing a field study, we aim to see how project success can be achieved through project manager motivation by having trust and knowledge sharing among employees inside an organization. Furthermore, we propose a research model that shows the relationship between project manager motivation on project success. In view of gathering data, 400 questionnaires were distributed among workers of the telecommunication sector of Pakistan. Where 16 questionnaires were not filled properly and excluded from the studies. 384 questionnaires were analyzed. Furthermore, the outcome of the gathered data is Analyzed from Smart PLS and shows the positive impact of project managers motivation over project success by sharing knowledge and trust with each other.
ANALYSIS OF MICRO-STRIP PATCH ANTENNA FOR WI-FI APPLICATIONS
Authors: Das Hangsa Raj , Dey Rajesh , Bhattacharya Sumanta
Published: January 2021

For the purposes of Wi-Fi applications, the objective of this Rectangular Micro-Strip Patch antenna design. The aim of this research paper is to design, simulate, test and analyses a new form of rectangular micro-stip patch antenna with both RT Duroid and two-feed line substrates. The proposed model consists of the Linear Polarization Moment Process. The latest concept analytical analysis is simulation using the HFSS tool and the ZNB20 vector network analyzer (VNA) is used for experimental validation.
PERFORMANCE EVALUATION OF PKL (PATHOR KUCHI LEAF) ELECTRICITY FOR USE IN TELEVISION AND RADIO
Authors: Khan K.A. , Islam Shahinul , Rasel S. R. , Saime M. A. , Hossain Sazzad , Rahman Md. Atiqur
Published: January 2021

A new method of electricity generation based on Pathor Kuchi (Genus:Kalanchoe,Section:Bryophyllum) Leaf has been designed and developed at the Department of Physics, Jagannath University,Dhaka- 1100,Bangladesh.For accurate sizing of Television and Radio PKL electric modules are necessary to optimize the module size for operation. It was realized that a vast majority of rural households in Bangladesh were left unelectrified by conventional gas based electricity. The field performance studies of the technical aspects, the projected specific capital cost and the average daily generation and efficiency of the PKL module have been found for both Radio and TV from collected data. Attempts have been made to correlate certain measurable parameters with anticipated performance of the PKL system. Chemical, physical and mechanical properties of the PKL, Short Circuit Current (ISC), Open Circuit Voltage (VOC),Temperature effect of the PKL malt, pH of the PKL malt, Titratable acidity of the PKL malt, Generation of PKL electricity, Storage system of the PKL electricity, Practical utilization of PKL electricity use in Load(Television and Radio), Classification of PKL, Longevity of the PKL malt for PKL electricity generation, Preparation of PKL electric unit cell, module, panel, arrays and the constituent elements of the PKL have been studied. In experimental study, it is shown that ,the pH of the PKL malt is ≈ 4.6 (without water), pH of the PKL malt is ≈ 4.8(with 10% solution), the titratable acidity of the PKL malt is ≈ 0.88% and the constituent elements/ ions of the PKL malt is Fe++ and Cl-. Most of the results have been tabulated and graphically discussed.
Co wspólnego ma Wniebowzięcie Marii z Ostatnią Wieczerzą, czyli o genezie formy i ikonografii późnośredniowiecznego obrazu ze zbiorów Muzeum Narodowego w Poznaniu,(...)
Authors: Woziński Andrzej
Published: January 2021

The late medieval panel painting of the Assumption of Virgin Mary from the Collection of the National Museum in Poznań was most likely created in Greater Poland (Wielkopolska), probably in Poznań, in the early 16th century. Scholars have pointed out the connection of its iconography with several other art pieces from the area of Greater Poland. In the light of these findings, our painting seemed to be traditional in the terms of form, as well as of content. This paper shows that some formal solutions and motifs used in the painting from Poznań differ from a typical iconographic practice, and it has only partial coverage in literary sources. The Apostles’ behaviour not fully corresponding to the subject and the chair in which an unidentified Apostle is sitting in a strangely complicated pose by the sarcophagus are the exceptional traits of the Poznań painting. The reason for their presence is the fact that the painter quoted a large part of the copperplate engraving of the Netherlandish Master IAM of Zwolle on a completely different subject: the Last Supper. The painter repeated selected elements quite accurately, without trying too much to adopt them to the new context. The Poznań painting is one of the countless examples of the use of prints as a pattern in the late medieval workshop practice. But at the same time, it belongs to the smaller in number works that were created in a more sophisticated way, through a compilation of motifs taken from various sources, combined with iconographic transformations. The paintings of Jörg Stoker, active in Ulm, and the prominent Antwerp artist Joos van Cleve analysed in the paper, are the examples of the application of a similar creative procedure. The last part of the text is devoted to the reception of the copperplate engraving by Master IAM of Zwolle, which determined so markedly the form and iconography of the painting at the National Museum in Poznań. The range of impact of this pattern, including Northern France, Greater Poland, Austria, Southern Germany (?), Northern Italy, Sardinia and Castilla, illustrates how universal, despite all the regional differences, the visual culture of Latin Europe was at the time.
Nieznany złotniczy znak miejski Gdańska z czwartej ćwierci XVII w.
Authors: Kriegseisen Jacek
Published: January 2021

Goldmisth’s hallmarks, particularly city ones used within the territory of the PolishLithuanian Commonwealth, have been the object of interest of numerous scholars since the late 19th century. The reason being that not only do they facilitate the attribution of definite historic silverware pieces to a definite goldsmithery centre, but they are also helpful when the results of stylistic analysis prove too wide too define a more precise time of their creation.

Puncheons used to stamp city hallmarks on silver, as is proven by the preserved historic pieces, depending on the intensity of use and degree of wear, were in service either for a shorter time: a year or several years, or a longer time, sometimes some dozen years. For this reason it is hard or almost impossible to ascertain which Guild’s Elder, alternating yearly, authorized to stamp the city hallmark, actually marked the product. The problem disappeared only when in Gdansk the duty to stamp a peculiar countersignature, namely an additional control sign, was introduced in 1730.

The hallmark presented in the paper is a previously unrecorded version of the city of Gdansk’s hallmark, whose use can now be dated to 1683–1688, though it was in actual use for a shorter time. However, already with such-defined chronology of the use of hallmarks Nos. 5A–E, a more precise dating of historic pieces of Gdańsk goldsmithery is possible.
La salvaguardia: El caso de la industria del acero en México
Authors: Núñez García Aleida , Lechuga Cardozo Jorge Isaac
Published: January 2021

El objetivo de este artículo es mostrar evidencia de la aplicación de medidas arancelarias y no arancelarias como la salvaguardia para la defensa comercial de la industria del acero en México, aunado a la importancia de la correcta clasificación arancelaria de los productos sensibles como el acero. Se definió un estudio cuantitativo, no experimental, de tipo explicativo, se utilizó como técnica de investigación la minería de datos. Los resultados de dicho estudio indican que existe una caída en las importaciones de acero probablemente por la publicación que realizó la Secretaría de Economía sobre Modificaciones a la Tarifa de la Ley de los Impuestos Generales de Importación y de Exportación para las mercancías originarias de América del Norte, en función de la salvaguardia del acero en México. Se concluye que la correcta clasificación arancelaria de las mercancías en materia de acero permitirá cumplir las regulaciones y restricciones no arancelarias, el pago de contribuciones al comercio exterior, las diversas a estas, y el pago de cuotas compensatorias, en el caso que éstas últimas apliquen, lo que evitará consecuencias jurídicas y administrativas significativas por la autoridad aduanera.
Mediación Familiar en México. Avances en Justicia alternativa para conflictos familiares
Authors: Castillo Caraveo Araceli
Published: January 2021

El presente artículo es resultado de una revisión que tuvo por objetivo analizar el desarrollo de la mediación dirigida a las entidades federativas y su impulso en la mediación familiar, así como los avances que estas han tenido respecto a los desarrollos de este proceso de justicia alternativa a nivel nacional, por lo que para hacer propuestas en la materia, se necesita indagar respecto a cómo se encuentra este proceso alternativo en la actualidad y de qué manera la contemplan actualmente, desde sus legislaciones especializadas hasta los números de asuntos que han resuelto en el último año, de modo que, se analizará conforme a las estadísticas y las legislaciones, aquellos avances que han tenido en la mediación familiar.
TO STUDY THE IMPACT OF DETERMINANTS OF GROWTH ON FIRM’S PERFORMANCE WITH RESPECT TO IT INDUSTRY
Authors: Saxena Mayank , Maru Sumeet
Published: January 2021

Firm growth is an important indicator of a thriving economy. Although the determinants of firm growth have been studied in various disciplines, an integrated analysis is still lacking. Many determinants of firm growth are summarized and classified into three dimensions: individual, organizational, and environmental determinants. The present paper attempts to provide an integrated analysis on the determinants of firm growth. It gives an opportunity to investigate the determinants of firm growth in a comprehensive way.

The close-ended questionnaire was developed from standard questions of relevant literature as a research instrument. The sample size taken for the research is of 110 IT firms entrepreneurs.

Among the individual determinants, need for achievement, risk taking propensity and self-efficacy are positively conducive to firm growth. Among the organizational determinants, formulation, preparedness to grow, organizational learning, financial performance have positive impacts on firm growth. Market orientation, Entrepreneurial orientation, competitive intensity shows a negative relationship. Among the Entrepreneurial determinants, munificence, heterogeneity has positive impacts on firm growth. Market dynamism shows a negative relationship. Growth Barriers shows negative relationship.

Our study shows that firm growth is a complex phenomenon. It cannot be explained by one particular dimension or one determinant. The most important determinants have been identified from the individual, environmental and organizational dimensions. Organizational determinants have the greatest influence on firm growth.
OPTIMIZATION OF EDIBLE FILM FORMULA BASED ON MAIZENA, CARRAGEENAN, AND RICE BRAN FOR HAND CANDY PACKAGING
Authors: Purwoto Heri , Ismawanti Ratih Dwi , Harianto Harianto , Djafar M. Jusuf , Putri Widya Dwi Rukmi , Murtini Erni Sofia
Published: January 2021

Plastic packaging has dominated the waste, and the number is increasing every year. Candy plastic packaging waste is most often considered trivial because of its small size, so it is usually disposed of carelessly. Due to its non-biodegradable, it causes environmental pollution. Edible film packaging is an alternative to reduce the impact of candy packaging waste pollution. The purpose of this study was to obtain the optimum formula of the edible film between corn starch, carrageenan, and rice bran as a hard candy packaging with the Response Surface Methodology (RSM) Central Surface Composite Design using the Design Expert 10.0.7. The prediction data obtained is then verified and tested by t-test at a 5% reliance interval.The optimum formulation of RSM results is 3.4% of corn starch, 1.1% of carrageenan and 0.38% of rice bran with predicted response of water content of 14.51%, WVTR 61,06 g/m2/hour, viscosity of 258.8 cP, tensile strength of 107.9 kgf/cm2, elongation of 19.41%, and modulus of response young 586.28 kgf/cm2. The verification of the optimum formula had a moisture content of 14.37%, WVTR 63.34 g/m2/hour, viscosity of 244.9 cP, tensile strength of 96.9 kgf/cm2, elongation of 20.96%, and young modulus of 462.49 kgf/cm2.
ANTI-VANDALISM SYSTEM FOR MONITORING SMART LEVEL CROSSING PROPERTY: A COMPREHENSIVE REVIEW
Authors: Rosyidi M. , Fiantika Thiya , Irawati Novi , Nugroho Sinung
Published: January 2021

This research addresses the problem of vandalism incident related to the smart level crossing technology. Smart level crossing system is essential as a safety system inside the level area, because of that any failure related to the System will endanger the railway and road user. Another subsystem that protects smart level crossing property is critical. This research will show the plan for applying anti-vandalism technology and analysis another possibility of technology related to the System.
IMPLEMENTATION OF ROOT CAUSE ANALYSIS METHOD TO INVESTIGATE FAILURE OF FRONT WALL TUBE BOILER
Authors: Febriyanti Eka , Suhadi Amin , Sari Laili Novita
Published: January 2021

Root cause analysis is a method that observes all of the possible causes that make the system or components fail. This research is implemented such a method to investigate the failed front wall tube on the boiler. The purpose of this research is to find out the main cause of failure on the front wall tube to avoid a similar problem in the future.  Considering all aspects that have the potential to be the main cause of failure, therefore, many tests and examinations are done, including visual tests, fractography, metallography, chemical analysis, hardness test, SEM, and EDS analysis.  Examination result on the fracture surface shows two bulges on a tube and some longitudinal cracks spread on bulges outside the surface area. At the same time, the thick scale is also found on the inside surface of these bulges. Moreover, microstructure and hardness changes are also found in this area.  From the analysis of all test result that obtained it is concluded that the main cause of failure is the presence of scales which reduce heat transfer so that local overheating occurred.  Consequently, its tensile strength in this area is decreased, and finally, the tube could not support operational pressure and deformed to make a bulge.
MECHANOSYNTHESIS OF MMC Cu-C DOPED WITH Ti FOR APPLICATION OF PANTOGRAPH CONTACT STRIP (PCS)
Authors: Rahmanullah Andhika Abdan , Pawawoi Pawawoi , Prajitno Djoko Hadi
Published: January 2021

This research was conducted to determine the effect of the addition of Titanium (Ti) and the sintering temperature variation on MMC CuC alloys as reinforcing elements. The process of this research uses powder metallurgical method with an alloying technique in Mechanical Alloying using a Planetary Ball Mill (PBM) machine with a speed of 600 rpm for 2 hours, the ratio of powder to the ball mill is 10:1. The compacting process is carried out using dies 11 mm in diameter and compacting pressure of 90 Kg/cm2. The sintering process is carried out three times, with variations in sintering of 800oC, 900oC, and 1000oC with sintering time for 1 hour in the tube furnace in the argon gas vacuum environment. The number of samples used in this study amounted to 9 samples with variations in alloy and temperature sintering, consist of MMC CuC alloy with addition of Ti 0%, 0.5%, 1.5% (T=800 oC), MMC CuC with  addition of Ti 0%, 0.5%, 1.5% (T=900 oC), and MMC CuC with addition of Ti 0%, 0.5%, 1.5% (T=1000 oC). The tests included Vickers hardness testing, metallography testing, XRD testing, and SEM-EDS testing. The addition of Ti elements and varying sintering temperature had an effect on the hardness value of MMC CuC material with the highest hardness value in samples with 1.5% Ti alloy (800oC) which is 87.25 HV, and the lowest porosity value is 2.491% in the sample of 1.5% Ti (1000oC).
The Art of Making Workplace Innovative: Conceptual Integration of Leader-Member Exchange, Workplace Innovation and Employee Creativity
Authors: Ul ain Aslam Qurat , Ali Rabia , Choudhary Ali Iftikhar
Published: January 2021

An increased engagement in innovative activities has become an essential requirement for modern ventures to respond to the threats and opportunities they face. Due to increased globalisation and digitalisation, SME ventures are currently looking for ways to cultivate innovation at different levels such as individual, team and organisational levels to remain competitive. SME ventures need to focus on employee creativity in order to stimulate innovation at the individual level. Moreover, a favourable working environment is required for such cultivation. This short commentary aims to conduct an extant literature review proposing that Leader-Member Exchange (LMX) impacts employee creativity and workplace innovation mediates the relationship between them. Based on the social exchange theory, the literature on LMX, employee creativity, and workplace innovation is reviewed. This study's conceptual model opens new avenues for empirical studies and may help leaders cultivate innovation for improved organisational performance. The current study suggests that SME ventures should implement better LMX practices and better interaction with employees to cultivate ideas aimed to improve employee creativity.