bluuebunny/crossref_metadata_2025 huggingface dataset:
The Acute Flaccid Paralysis (AFP) Surveillance System in Yemen, 2010-2015: Descriptive Study Based on Secondary Data Analysis
Authors: Almoayed Khaled Abdullah , Bin Break Ali , Al-Qassimi Mutahar , Assabri Ali , Khader Yousef
Published: October 2019

Background

Acute flaccid paralysis (AFP) surveillance is an essential strategy for poliovirus eradication.

Objective

This study aimed to evaluate the performance of the AFP surveillance system in Yemen from 2010 to 2015, identify components that require strengthening, and compare the indicators by year and governorates.

Methods

This descriptive study was based on secondary analysis of AFP surveillance data reported during 2010-2015 from all Yemeni governorates. The World Health Organization (WHO) minimum performance standards were used to evaluate the performance of the AFP surveillance system.

Results

A total of 3019 AFP cases were reported between January 2010 and December 2015. At the national level, AFP surveillance achieved WHO targets throughout the evaluating period for the nonpolio AFP rate of cases per 100,000 members of the population younger than 15 years of age, proportion of AFP cases reported within 7 days, proportion of AFP cases investigated within 48 hours of notification, proportion of AFP cases with two adequate stool specimens, and proportion of stool specimens from which nonpolio enterovirus was isolated. However, the proportion of specimens that arrived at the central level within 3 days of the first sample collection and the proportion of stool specimens with results sent from the reference laboratory within 28 days of receipt did not reach targets in 2011 and 2015, respectively.

Conclusions

The AFP surveillance system in Yemen has met most of the WHO indicator levels. Nevertheless, the evaluation showed areas of weakness regarding the arrival of specimens at the central level within 3 days of the first sample collection and delays in processing of the results and submitting feedback by the laboratory. Therefore, there is a need to strengthen the follow-up of specimens submitted to the laboratory.
Just Because (Most) Hospitals Are Publishing Charges Does Not Mean Prices Are More Transparent
Authors: Mullens Cody Lendon , Hernandez J Andres , Anderson Evan D , Allen Lindsay
Published: October 2019

Background

The Centers for Medicare and Medicaid Services (CMS) recently mandated that all hospitals publish their charge description masters (CDMs) online, in a machine-readable format, by January 1, 2019. In addition, CMS recommended that CDM data be made available in a manner that was consumer friendly and accessible to patients.

Objective

This study aimed to (1) examine all hospitals across the state of Pennsylvania to understand policy compliance and (2) use established metrics to measure accessibility and consumer friendliness of posted CDM data.

Methods

A cross-sectional analysis was conducted to quantify hospital website compliance with the recent CMS policies requiring hospitals to publish their CDM. Data were collected from all Pennsylvania hospital websites. Consumer friendliness was assessed based on searchability, number of website clicks to data, and supplemental educational materials accompanying CDMs such as videos or text.

Results

Most hospitals (189/234, 80.1%) were compliant, but significant variation in data presentation was observed. The mean number of website clicks to the CDM was 3.7 (SD 1.3; range: 1-8). A total of 23.1% of compliant hospitals provided no supplemental educational material with their CDM.

Conclusions

Although disclosure of charges has improved, the data may not be sufficient to meaningfully influence patient decision making.
Using Mobile Devices to Deliver Lifestyle Interventions Targeting At-Risk High School Students: Protocol for a Participatory Design Study
Authors: Müssener Ulrika , Löf Marie , Bendtsen Preben , Bendtsen Marcus
Published: October 2019

Background

Unhealthy lifestyle behaviors such as insufficient physical activity, unhealthy diet, smoking, and harmful use of alcohol tend to cluster (ie, individuals may be at risk from more than one lifestyle behavior that can be established in early childhood and adolescence and track into adulthood). Previous research has underlined the potential of lifestyle interventions delivered via mobile phones. However, there is a need for deepened knowledge on how to design mobile health (mHealth) interventions taking end user views into consideration in order to optimize the overall usability of such interventions. Adolescents are early adopters of technology and frequent users of mobile phones, yet research on interventions that use mobile devices to deliver multiple lifestyle behavior changes targeting at-risk high school students is lacking.

Objective

This protocol describes a participatory design study with the aim of developing an mHealth lifestyle behavior intervention to promote healthy lifestyles among high school students.

Methods

Through an iterative process using participatory design, user requirements are investigated in terms of technical features and content. The procedures around the design and development of the intervention, including heuristic evaluations, focus group interviews, and usability tests, are described.

Results

Recruitment started in May 2019. Data collection, analysis, and scientific reporting from heuristic evaluations and usability tests are expected to be completed in November 2019. Focus group interviews were being undertaken with high school students from October through December, and full results are expected to be published in Spring 2020. A planned clinical trial will commence in Summer 2020. The study was funded by a grant from the Swedish Research Council for Health, Working Life, and Welfare.

Conclusions

The study is expected to add knowledge on how to design an mHealth intervention taking end users’ views into consideration in order to develop a novel, evidence-based, low-cost, and scalable intervention that high school students want to use in order to achieve a healthier lifestyle.

International Registered Report Identifier (IRRID)

DERR1-10.2196/14588
Use of a Fully Automated Internet-Based Cognitive Behavior Therapy Intervention in a Community Population of Adults With Depression Symptoms: Randomized Controlled Trial
Authors: Schure Mark B , Lindow Janet C , Greist John H , Nakonezny Paul A , Bailey Sandra J , Bryan William L , Byerly Matthew J
Published: October 2019

Background

Although internet-based cognitive behavior therapy (iCBT) interventions can reduce depression symptoms, large differences in their effectiveness exist.

Objective

The aim of this study was to evaluate the effectiveness of an iCBT intervention called Thrive, which was designed to enhance engagement when delivered as a fully automated, stand-alone intervention to a rural community population of adults with depression symptoms.

Methods

Using no diagnostic or treatment exclusions, 343 adults with depression symptoms were recruited from communities using an open-access website and randomized 1:1 to the Thrive intervention group or the control group. Using self-reports, participants were evaluated at baseline and 4 and 8 weeks for the primary outcome of depression symptom severity and secondary outcome measures of anxiety symptoms, work and social adjustment, psychological resilience, and suicidal ideation.

Results

Over the 8-week follow-up period, the intervention group (n=181) had significantly lower depression symptom severity than the control group (n=162; P<.001), with a moderate treatment effect size (d=0.63). Moderate to near-moderate effect sizes favoring the intervention group were observed for anxiety symptoms (P<.001; d=0.47), work/social functioning (P<.001; d=0.39), and resilience (P<.001; d=0.55). Although not significant, the intervention group was 45% less likely than the control group to experience increased suicidal ideation (odds ratio 0.55).

Conclusions

These findings suggest that the Thrive intervention was effective in reducing depression and anxiety symptom severity and improving functioning and resilience among a mostly rural community population of US adults. The effect sizes associated with Thrive were generally larger than those of other iCBT interventions delivered as a fully automated, stand-alone intervention.

Trial Registration

ClinicalTrials.gov NCT03244878; https://clinicaltrials.gov/ct2/show/NCT03244878
Understanding Drivers of Resistance Toward Implementation of Web-Based Self-Management Tools in Routine Cancer Care Among Oncology Nurses: Cross-Sectional Survey Study
Authors: de Wit Matthijs , Kleijnen Mirella , Lissenberg-Witte Birgit , van Uden-Kraan Cornelia , Millet Kobe , Frambach Ruud , Verdonck-de Leeuw Irma
Published: October 2019

Background

Supporting patients to engage in (Web-based) self-management tools is increasingly gaining importance, but the engagement of health care professionals is lagging behind. This can partly be explained by resistance among health care professionals.

Objective

The aim of this study was to investigate drivers of resistance among oncology nurses toward Web-based self-management tools in cancer care.

Methods

Drawing from previous research, combining clinical and marketing perspectives, and several variables and instruments, we developed the Resistance to Innovation model (RTI-model). The RTI-model distinguishes between passive and active resistance, which can be enhanced or reduced by functional drivers (incompatibility, complexity, lack of value, and risk) and psychological drivers (role ambiguity, social pressure from the institute, peers, and patients). Both types of drivers can be moderated by staff-, organization-, patient-, and environment-related factors. We executed a survey covering all components of the RTI-model on a cross-sectional sample of nurses working in oncology in the Netherlands. Structural equation modeling was used to test the full model, using a hierarchical approach. In total, 2500 nurses were approached, out of which 285 (11.40%) nurses responded.

Results

The goodness of fit statistic of the uncorrected base model of the RTI-model (n=239) was acceptable (χ21=9.2; Comparative Fit Index=0.95; Tucker Lewis index=0.21; Root Mean Square Error of Approximation=0.19; Standardized Root Mean Square=0.016). In line with the RTI-model, we found that both passive and active resistance among oncology nurses toward (Web-based) self-management tools were driven by both functional and psychological drivers. Passive resistance toward Web-based self-management tools was enhanced by complexity, lack of value, and role ambiguity, and it was reduced by institutional social pressure. Active resistance was enhanced by complexity, lack of value, and social pressure from peers, and it was reduced by social pressure from the institute and patients. In contrast to what we expected, incompatibility with current routines was not a significant driver of either passive or active resistance. This study further showed that these drivers of resistance were moderated by expertise (P=.03), managerial support (P=.004), and influence from external stakeholders (government; P=.04).

Conclusions

Both passive and active resistance in oncology nurses toward Web-based self-management tools for patients with cancer are driven by functional and psychological drivers, which may be more or less strong, depending on expertise, managerial support, and governmental influence.
The True Colours Remote Symptom Monitoring System: A Decade of Evolution
Authors: Goodday Sarah M , Atkinson Lauren , Goodwin Guy , Saunders Kate , South Matthew , Mackay Clare , Denis Mike , Hinds Chris , Attenburrow Mary-Jane , Davies Jim , Welch James , Stevens William , Mansfield Karen , Suvilehto Juulia , Geddes John
Published: October 2019

The True Colours remote mood monitoring system was developed over a decade ago by researchers, psychiatrists, and software engineers at the University of Oxford to allow patients to report on a range of symptoms via text messages, Web interfaces, or mobile phone apps. The system has evolved to encompass a wide range of measures, including psychiatric symptoms, quality of life, and medication. Patients are prompted to provide data according to an agreed personal schedule: weekly, daily, or at specific times during the day. The system has been applied across a number of different populations, for the reporting of mood, anxiety, substance use, eating and personality disorders, psychosis, self-harm, and inflammatory bowel disease, and it has shown good compliance. Over the past decade, there have been over 36,000 registered True Colours patients and participants in the United Kingdom, with more than 20 deployments of the system supporting clinical service and research delivery. The system has been adopted for routine clinical care in mental health services, supporting more than 3000 adult patients in secondary care, and 27,263 adolescent patients are currently registered within Oxfordshire and Buckinghamshire. The system has also proven to be an invaluable scientific resource as a platform for research into mood instability and as an electronic outcome measure in randomized controlled trials. This paper aimed to report on the existing applications of the system, setting out lessons learned, and to discuss the implications for tailored symptom monitoring, as well as the barriers to implementation at a larger scale.
Intelligent Sensing to Inform and Learn (InSTIL): A Scalable and Governance-Aware Platform for Universal, Smartphone-Based Digital Phenotyping for Research and Clinical Applications
Authors: Barnett Scott , Huckvale Kit , Christensen Helen , Venkatesh Svetha , Mouzakis Kon , Vasa Rajesh
Published: October 2019

In this viewpoint we describe the architecture of, and design rationale for, a new software platform designed to support the conduct of digital phenotyping research studies. These studies seek to collect passive and active sensor signals from participants' smartphones for the purposes of modelling and predicting health outcomes, with a specific focus on mental health. We also highlight features of the current research landscape that recommend the coordinated development of such platforms, including the significant technical and resource costs of development, and we identify specific considerations relevant to the design of platforms for digital phenotyping. In addition, we describe trade-offs relating to data quality and completeness versus the experience for patients and public users who consent to their devices being used to collect data. We summarize distinctive features of the resulting platform, InSTIL (Intelligent Sensing to Inform and Learn), which includes universal (ie, cross-platform) support for both iOS and Android devices and privacy-preserving mechanisms which, by default, collect only anonymized participant data. We conclude with a discussion of recommendations for future work arising from learning during the development of the platform. The development of the InSTIL platform is a key step towards our research vision of a population-scale, international, digital phenotyping bank. With suitable adoption, the platform will aggregate signals from large numbers of participants and large numbers of research studies to support modelling and machine learning analyses focused on the prediction of mental illness onset and disease trajectories.
Analisis Location Quotient (LQ) Komoditas Cabai di Kabupaten Kediri
Authors: Astasari Cynthia Paramita , Ibrahim Jabal Tarik , Harpowo Harpowo
Published: October 2019

Chili is vegetables that have an important role in agriculture in Indonesia. Generally, the amount of chili production is determined by the harvested area and productivity of the land. Chili is one of the main horticulture products in Indonesia. Kediri District is potential as a center of chili’s production. According to Ibrahim, 2012 there are four major sub-district in the production of chili commodities, such as Kepung District, Puncu District, Papar District, and Pagu District. The determination of a commodity to be a superior commodity in Kediri District based on the consideration that not all vegetable commodities are suitable to be developed in all places. The purpose of this research is 1) Knowing the growth of chili’s production, 2) Analyze the Location Quotient of chili in Kediri District, 3) Analyze the Location Quotient of cayenne in Kediri District. This research is using secondary data. This research data was analyzed by Location Quotient (LQ). This research shows that the growth of harvested area has fluctuated every year. Chili’s production has fluctuated during 2014-2016. Cayenne’s production has fluctuated during 2014-2016. Mojo sub-district is basis area of harvested area and chili’s production for last three years. Pagu District sub-district is basis area of harvested area and cayenne’s production for last three years.
Analisis Pendapatan Non Halal Perbankan Syariah Di Indonesia: Sumber Dan Penggunaannya
Authors: Hartanto Rudy , Pramono Irena Paramita , Purnamasari Pupung
Published: October 2019

The existence of the regulation for Islamic banking causes it to conduct its activities by the guidance of Islamic principles which avoid some non-halal sources of income. On the other hand, the transactions between Islamic banking and conventional banking are unavoidable because conventional financial institutions still dominate all transactions in each country. This means that non-halal sources of income cannot be avoided, by the way of the transaction is done. This research aims to analyze on the sources of income and its distribution of the non-halal funds of Islamic Banks in Indonesia. This research is quantitative. The method of collecting data documentation uses data from 2015-2017 with a total sample of 102 Islamic banks. The results show that there were differences in the average non-halal funds of Islamic Commercial Banks with Islamic Business Unit Bank. In addition, this study shows that Islamic commercial bank tends to have non-halal funds bigger than Islamic Business Unit Bank. On the other hand, the result shows that non-halal funds sources in the banking industry are dominated by interest income from another conventional bank and the using of non-halal funds is dominated by social activities.
Faktor-Faktor yang Mempengaruhi Pemilihan Model Bagi Hasil Pada Sektor Pertanian di Wilayah Karesidenan Madiun
Authors: Adib Susilo Suyoto Arief , Susilo Adib
Published: October 2019

The purpose of this study was to determine whether socioeconomic factors, production factors, religiosity factors, and transparency factors influence the selection of agricultural production sharing models in the Residency of Madiun. This research is quantitative with multiple regression analysis. Based on the T-test, socioeconomic factors partially have a significant influence on the selection of agricultural production sharing models in the Madiun Residency of 3.701. Meanwhile, the factor of religiosity has a significant effect on the selection of agricultural production sharing models in the Madiun Residency with a significance level of 0.039. Furthermore, the factor of production does not have a significant effect with a significance level of 0.778. Finally, it is a factor that has a significant influence on the selection of revenue sharing models with a significance level of 0.008. While based on ANOVA test results, the F count of 10.288 with a significance level of 0.000 is smaller than 0.05, which means that socioeconomic, religiosity, production, and transparency factors simultaneously have an influence on the selection of revenue sharing models.
The extraction of SR2+ with dicyclohexano-18-crown-6 in conventional organic solvent and ionic liquid diluents
Authors: Wei Zheng , Gao Yang , Zhou Yu , Jiao Caishan , Zhang Meng , Hou Hongguo , Liu Wei
Published: October 2019

90Sr (t1/2 = 28.8 a), one of the most significant fission products in high-level radioactive liquid waste (HLLW), contributes to a large part of the heat load and radiation. Removal of 90Sr from the HLLW is beneficial for the final treatment of nuclear waste. In this paper, the extraction of Sr2+ was carried out using dicyclohexano-18-crown-6 (DCH18C6) in a variety of diluents including conventional organic solvents and novel ionic liquid solvents. The effect of several factors, such as nitric acid concentration, crown ether concentration and initial strontium concentration on the extraction of Sr2+ have been studied comprehensively. The higher distribution ratio and the stripping efficiency of Sr2+ were obtained with the binary diluents consisted of n-octanol and acetylene tetrachloride, which were compared with that using pure n-octanol as diluent. As for the CnmimNTf2 (n = 2, 4, 6) ionic liquid solvent systems, the distribution ratio of Sr2+ was much higher in the nitric acid medium with low concentration than in the traditional solvent systems. The results showed that DC2mimNTf2 > DC4mimNTf2 > DC6mimNTf2, which indicated that shorter carbon chain benefits the extraction of Sr2+.
Evaluation of the effects of the hybrid Pendulum in comparison with the conventional Pendulum appliance
Authors: Bozkaya Erdal , Tortop Tuba , Yüksel Sema , Kaygısız Emine
Published: October 2019

Objective:

To evaluate the anchorage control and distalization of maxillary molars with the hybrid Pendulum appliance and to compare the results with a conventional Pendulum appliance.

Materials and Methods:

This study was carried out on the pre-(T0) and post-(T1) treatment lateral cephalograms and dental casts of 43 patients with Angle Class II molar relationships who were treated with conventional or hybrid Pendulum appliances. The hybrid Pendulum (HP) group consisted of 22 patients (14 females; eight males; mean age 14.3 ± 2.43 years) and treatment results were compared with a conventional Pendulum appliance (CP) group, which consisted of 21 patients (15 females; six males; mean age 14.6 ± 3.39 years). Intragroup comparisons were made with Wilcoxon test and intergroup comparisons were made with Mann-Whitney U-test (P < .05).

Results:

The mean distalization duration was 0.70 ± 0.25 years in the HP group and 0.83 ± 0.4 years in the CP group. Maxillary first molars showed significant distal movement and tipping of 4.25 mm and 9.09° in the HP group, and 3.21 mm and 9.86° in the CP group. Loss of anchorage at the first premolars was significantly smaller in the HP appliance group compared to CP group. The second premolars distalized spontaneously in the HP group while they mesialized significantly in the CP group. Proclination and protrusion of maxillary incisors were greater with the CP appliance compared to the HP appliance.

Conclusions:

Maxillary molar distalization was achieved with both appliances. Mesialization of the anchorage unit was controlled successfully with the hybrid Pendulum; however, the conventional Pendulum appliance caused anchorage loss.
Luisina Perelmiter. Burocracia plebeya. La trastienda de la asistencia social en el Estado argentino. San Martín: Universidad Nacional de San Martín, 2016, 251 pp.
Authors: Guthmann Yanina
Published: October 2019

La literatura que analiza el Estado con una mirada micro-política no es muy amplia en Argentina. Burocracia Plebeya, La trastienda de la asistencia social en el Estado argentino brinda un análisis sociológico del funcionariado medio del Ministerio de Desarrollo Social en Argentina durante los gobiernos de Néstor y Cristina Kirchner y muestra a través de una estrategia etnográfica rigurosa, aspectos esenciales de las prácticas y pensamiento burocrático, detrás de la búsqueda de mayor proximidad con los sectores vulnerables, como meta y forma esencial de lo institucional.
La reconstrucción del sentido en madres de niños con una enfermedad degenerativa
Authors: Mora Huerta Carolina , Rivera Navarro Jesús
Published: October 2019

El artículo presenta los resultados sobre cuidado y maternidad de una investigación que tiene como objetivo explicar los procesos de reconstrucción del sentido en familias con un hijo con una enfermedad degenerativa. La investigación se realiza a través de un proceso cualitativo con enfoque constructivista social. La recolección de datos es a través de método metafórico, entrevista enfocada y observación participante; el análisis se realiza por método metafórico y análisis cualitativo. Se encuentra que el sentido se reconstruye en los diversos discursos socioculturales, puede relacionarse con las creencias religiosas; maternidad y cuidado son procesos corporizados en la mujer.
Referentes formativo-deportivos en el fútbol base español: un escenario socioeducativo complejo
Authors: Merino Orozco Abel , Jarie Laurane , Usán Supervía Pablo
Published: October 2019

El fútbol es la actividad físico-deportiva más practicada en España en edad escolar y posee implicaciones formativas de relevancia para quien lo practica. Existe un interés educativo por intervenir en el deporte a fin de revalorizar las oportunidades formativas únicas que este ofrece. Por ello, se han emprendido acciones que inciden en pautar el comportamiento de formadores y familiares. Este artículo pretende realizar un recorrido exhaustivo por los referentes formativos que contribuyen en los aprendizajes que los niños construyen, desde la premisa de que la no formalidad del escenario facilita la permeabilidad de referentes dando lugar a un espacio dinámico y complejo. Esta percepción pretende favorecer una certidumbre formativa que vincule la convergencia de las buenas prácticas que atiendan la complejidad referencial del escenario formativo-deportivo que es el fútbol escolar.
Tempo despendido durante 12 semanas de treinamento e desempenho tático-técnico no voleibol escolar
Authors: Grisi Raianne De Brito , Pontes Nayara Elis Cabral , Domingos Jarbas Rallison , Silva Leopoldo Sindice da , Costa Yago Pessoa da , Torres Vitor Bruno Cavalcanti , Batista Gilmário
Published: October 2019

O objetivo do estudo foi comparar o tempo de treinamento das habilidades motoras do voleibol despendido durante 12 semanas em equipes escolares, tendo como objetivo secundário comparar indicadores de performance durante uma competição. Trata-se de uma pesquisa com delineamento longitudinal. Foram acompanhados durante 12 semanas o treinamento de cinco equipes, sendo suas ações registradas em fichas, em seguida foram filmados 16 jogos do campeonato escolar da Paraíba das referidas equipes. A Anova one-way identificou diferenças entre as equipes no tempo despendido e nos indicadores de performance entre as equipes classificadas de acordo com a posição no ranking da competição. Concluiu-se que o tempo despendido no treinamento é fundamental par o desempenho durante a competição.
Effect of oral administration of gabapentin on the minimum alveolar concentration of isoflurane in dogs
Authors: Johnson Brittney A. , Aarnes Turi K. , Wanstrath Audrey W. , Ricco Pereira Carolina H. , Bednarski Richard M. , Lerche Phillip , McLoughlin Mary A.
Published: October 2019

OBJECTIVE

To determine the effect of oral administration of gabapentin (20 mg/kg) on the minimum alveolar concentration (MAC) of isoflurane in dogs.

ANIMALS

6 healthy adult dogs (3 males and 3 females with a mean ± SD body weight of 24.8 ± 1.3 kg).

PROCEDURES

Each dog was anesthetized twice. Dogs were initially assigned to 1 of 2 treatments (gabapentin [20 mg/kg, PO] followed 2 hours later by anesthesia maintained with isoflurane or anesthesia maintained with isoflurane alone). A minimum of 7 days later, dogs received the other treatment. The MAC of isoflurane was determined by use of an iterative bracketing technique with stimulating electrodes placed in the maxillary buccal mucosa. Hemodynamic variables and vital parameters were recorded at the lowest end-tidal isoflurane concentration at which dogs did not respond to the stimulus. Effect of treatment on outcome variables was analyzed by use of a paired t test.

RESULTS

Mean ± SD MAC of isoflurane was significantly lower when dogs received gabapentin and isoflurane (0.71 ± 0.12%) than when dogs received isoflurane alone (0.91 ± 0.26%). Mean reduction in MAC of isoflurane was 20 ± 14%. Hemodynamic variables did not differ significantly between treatments. Mean time to extubation was significantly less when dogs received gabapentin and isoflurane (6 ± 4 minutes) than when dogs received isoflurane alone (23 ± 15 minutes).

CONCLUSIONS AND CLINICAL RELEVANCE

Oral administration of gabapentin 2 hours before anesthesia maintained with isoflurane had a MAC-sparing effect with no effect on hemodynamic variables or vital parameters of dogs.
Effect of site of sample collection and prandial state on blood glucose concentrations measured with a portable blood glucose meter in healthy dogs
Authors: Guevara Jose L. , Tobias Karen M. , Stokes Jennifer E. , Zhu Xiaojuan , Smith Rebecca A.
Published: October 2019

OBJECTIVE

To compare glucose concentrations in peripheral venous and capillary blood samples collected from dogs before and after consumption of a meal and measured with a veterinary-specific portable blood glucose meter (PBGM).

ANIMALS

12 dogs (96 blood samples).

PROCEDURES

A veterinary-specific PBGM was used to measure blood glucose concentrations. Glucose concentrations in capillary blood samples obtained from the carpal pad, medial aspect of a pinna, and oral mucosa were compared with glucose concentrations in blood samples obtained from a lateral saphenous vein. Samples were collected after food was withheld for 12 hours and again 2 hours after consumption of a meal.

RESULTS

Location of capillary blood collection had a significant effect on glucose concentrations measured with the PBGM. Glucose concentration in capillary blood collected from the medial aspect of the pinna did not differ significantly from the glucose concentration in peripheral venous blood samples, whereas glucose concentrations in blood samples collected from the carpal pad and oral mucosa differed significantly from the glucose concentration in peripheral venous blood samples. There was no significant difference between preprandial and postprandial blood glucose concentrations.

CONCLUSIONS AND CLINICAL RELEVANCE

Glucose concentrations in capillary blood collected from the medial aspect of the pinna of dogs better reflected glucose concentrations in venous blood than concentrations measured in capillary blood collected from the carpal pad or oral mucosa.
Efektivitas Putusan Mahkamah Konstitusi Nomor 18 Tahun 2013 Tentang Akta Kelahiran Yang Melampaui Batas 1 (Satu) Tahun Pada Dinas Kependudukan Dan Pencatatan Sipil Kabupaten Bintan
Authors: A.Karim Zamzai , Budiman Sharil , Syarifuddin M , Junriana
Published: October 2019

Dinas Kependudukan dan Pencatatan Sipil merupakan instansi pelaksana dalam penerbitan dokumen kependudukan, salah satunya adalah akta. Dalam implementasinya terdapat gejala permasalahan setelah terbitnya Putusan Mahkamah Konstitusi Nomor 18 tahun 2013 tentang Akta Kelahiran Yang Melampaui Batas 1 (satu) Tahun, dimana proses penerbitan akta kelahiran berdasarkan asas peristiwa kelahiran. Tujuan dalam penelitian ini adalah untuk mengetahui Efektivitas Pra dan Pasca Putusan Mahkamah Konstitusi Nomor 18 tahun 2013 tentang Akta Kelahiran Yang Melampaui Batas 1 (satu) Tahun pada Dinas Kependudukan dan Pencatatan Sipil Kabupaten Bintan. Metode Penelitian yang digunakan adalah metode penelitian deskriptif dengan pendekatan kualitatif. Data yang diperoleh melalui data primer dan skunder. Teknik pengumpulan data yang digunakan adalah Focus Group Discussion (FGD) dan wawancara tak berstruktur. Populasi yang digunakan adalah 75 orang dan yang dijadikan sampel sebanyak 25 orang. Teknik sampel yang digunakan adalah purposive sampling dan multistage sampling.Berdasarkan hasil penelitian dari data primer dan skunder yang penulis dapatkan, diketahui Efektivitas Pra dan Pasca Putusan Mahkamah Konstitusi Nomor 18 tahun 2013 tentang Akta Kelahiran Yang Melampaui Batas 1 (satu) Tahun pada Dinas Kependudukan dan Pencatatan Sipil Kabupaten Bintan dilihat dari indikator dan dimensi sebagai pengukurnya bahwa masih terdapat kendala dalam pengurusan akta kelahiran bagi anak yang lahir di luar wilayah Kabupaten Bintan.
UPAYA PEMERINTAH DALAM PENINGKATAN INDUSTRI BATIK BAKARAN DI KABUPATEN PATI MELALUI PROGRAM EKONOMI KREATIF
Authors: Rohmah Usisa , Kusuma Ardli Johan , Rohilie Fachry
Published: October 2019

Tujuan penulisan ini adalah untuk melihat potensi Batik Bakaran di kab. Pati, Jawa Tengah yang mengalami pasang surut dan belum mampu bersaing dengan batik daerah lainnya. Batik Bakaran kembali digalakkan melalui program pemerintah ekonomi kreatif agar mampu bersaing di industri tingkat nasional. Tulisan ini menggunakan metode kualitatif deskriptif, dengan teknik pengumpulan data, menggunakan teknik “librarian research” dan “Interview”. Hasil penelitian ini menunjukkan bahwa pemerintah sudah memberikan dukungan terhadap para pengrajin Batik Bakaran untuk melakukan pengembangan melalui pelatihan SDM untuk merangsang inovasi pengrajin batik dalam hal penciptaan motif dan warna Batik Bakara agar lebih diminati konsumen. Namun ternyata hal tersebut belum mampu meningkatkan daya saing Batik Bakaran di industri nasional. Solusi untuk mengatasi permasalahan tersebut adalah dengan meningkatkan kemampuan para pelaku industri batik bakaran yang meliputi: (1) kemampuan memperkokoh posisi pasarnya, (2) kemampuan menghubungkan dengan lingkungannya, (3) kemampuan meningkatkan kinerja tanpa henti, dan (4) kemampuan menegakkan posisi yang menguntungkan.
Efektivitas Pelaksanaan Musyawarah Perencanaan Pembangunan (Musrenbang) Tingkat Kecamatan di Kota Tanjungpinang
Authors: Setyadiharja Rendra
Published: October 2019

Musyawarah Perencanaan dan Pembangunan (Musrenbang) adalah forum musyawarah dalam menentukan program prioritas dan strategi pencapaian program di tingkat Kecamatan. Dalam prosestersebut terdapat singkronisasi alokasi program pembangunan dan kebutuhan masyarakat. Penelitian ini bertujuan untuk mengetahui apakah dalam pelaksanaan Musrenbang Kecamatan Tanjungpinang Timur kota Tanjungpinang telah efektif dan usulan-usulan yang diajukan dalam Daftar Usulan Pembangunan Kecamatan Tanjungpinang Timur telah memenuhi kebutuhan masyarakat. Metode penelitian yangdigunakan dalam penelitian ini adalah metode kuantitatif. Berdasarkan hasil penelitian yang dianalisis dengan rumus indeks efektivitas dari De Garmo, Sullivan dan Canada, dapat disimpulkan bahwa efektifitasmusrenbang kecamatan memberikan tujuan yang efektif dalam pelaksanaan pembangunan. Dengan perolehan indeks tertinggi pada dimensi tujuan dengan jumlah nilai indeks 4.17 sehingga dapatdikategorikan efektif. Dimensi adaptasi dengan jumlah nilai indeks 3.87 sehingga dapat dikategorikan efektif dan indeks terendah berada pada dimensi integrasi dengan jumlah nilai indeks 3.70 sehingga dapatdikategorikan efektif. Dari keseluruhan hasil Indeks Efektivitas Pelaksaanan Musyawarah Perencanaan Pembangunan Tingkat Kecamatan Tanjungpinang Timur Di Kota Tanjungpinang dengan jumlah nilai indeks 3.96 sehingga dapat dikategorikan efektif.
Aplikasi Systematic Mapping Review Sebagai Upaya Pengukuran Efektivitas Pembangunan Desa Pesisir Natuna
Authors: Septiawan Armauliza
Published: October 2019

Penelitian ini mengkaji berbagai permasalahan pembangunan yang mencakup potret minimnyapartisipasi masyarakat desa dalam aktivitas perencanaan, alokasi sumber daya, pelaksanaan maupunpengawasannya. Dalam eksistensinya, problem pembangunan desa juga terjadi pada desa pesisir disekitar wilayah perbatasan dan terluar Indonesia, sehingga secara signifikan menginterpretasikannyasebagai inefektivitas pembangunan desa pesisir yang memotivasi dan menarik minat perhatian parapeneliti di Indonesia. Berbagai penelitian banyak dilakukan, namun belum ditemukan penelitian yangmemetakan pemikiran tentang efektivitas pembangunan desa pesisir secara sistematis (Riset Indeks,Inklusif Filtrasi dan Pemetaan). Studi ini mempergunakan pendekatan kualitatif dan secara teknis datayang dikumpulkan melalui filtrasi atau screening of paper terhadap 99 topik penelitian yang relevan danselanjutnya dianalisis menggunakan teknik systematic literature review yang menghasilkan diskusi danbahasan agregasi tentang arah penelitian kontemplatif yang dilakukan melalui analisis sistematisterhadap 21 topik penelitian terindeks yang telah dikumpulkan menggunakan teknik screening of papersdan dikelompokkan berdasarkan klasifikasi tertentu. Hasil analisis data penelitian inklusif secarasistematis, menjelaskan bahwa letak penelitian yang concern terhadap proses membangun desa secaraefektif mencakup perilaku agen pembangunan desa pesisir saat ini masih minim sehingga memerlukanupaya pngukuran keberhasilan proses pembangunan yang tepat bagi desa pesisir.
Uma análise sobre as estratégias utilizadas por alunos do Nível Superior perante questões envolvendo o Teorema de Pitágoras
Authors: Costa Júnior Wilson Souza , Perovano Ana Paula
Published: October 2019

Apresentaremos aqui o recorte de um estudo que analisou as estratégias adotadas por alunos recém-ingressados no Ensino Superior na Licenciatura em Matemática de uma universidade pública do interior da Bahia, diante da resolução de questões que envolvem o Teorema de Pitágoras. Adotamos por uma abordagem qualitativa e optamos pela pesquisa descritiva com a aplicação de um questionário a 32 alunos do referido curso, antes que tivessem contato com tal conteúdo na Universidade. Do total de questões analisadas, mais da metade eram respostas erradas, deixadas em branco ou incompletas. A maior parte das estratégias erradas foi classificada como estratégia com indícios de conhecimento do Teorema de Pitágoras, mas com erro nos procedimentos de resolução. Tais resultados nos dão indícios que alunos que ingressam no Ensino Superior ainda apresentam dificuldades que poderiam ter sido sanadas na Educação Básica.
On the new travelling wave solution of a neural communication model
Authors: YEL Gülnur
Published: October 2019

The aim of this study is to present some new travelling wave solutions of conformable time-fractional Fitzhugh–Nagumo equation that model the transmission of nerve impulses.  For this purpose, the improved Bernoulli sub-equation function method has been used.  The obtained results are shown by way of the the 3D-2D graphs and contour surfaces for the suitable values.
Preprocedural high - sensitivity C-reactive protein (hsCRP) decrease during intensive atorvastatin therapy: the presumable impact on atherosclerosis progression after coronary stenting
Authors: Shchinova A M , Shlevkova G V , Filatova A Yu , Potekhina A V , Osokina A K , Romasov I V , Zharova E A , Noeva E A , Samko A N , Masenko V P , Arefieva T I , Provatorov S I
Published: October 2019

Proinflammatory status is the risk factor for coronary atherosclerosis progression after coronary stenting (CS). Intensive statin treatment is associated with hsCRP concentration decline. Aim: to evaluate prognostic significance of preprocedural hsCRP level reduction with intensive statin regimen for coronary atherosclerosis progression during one year after CS. Materials and methods. We enrolled 102 patients with stable angina who were on list for scheduled CS. Group I (n=37) patients received atorvastatin 80 mg for 7 days before and 3 months after CS with further dose adjustment according to LDL; group II (n=65) patients received atorvastatin 20-40 mg/day for LDL goal achievement. HsCRP level was assessed at baseline, before CS and after 1, 3, 6 and 12 months. Coronary atherosclerosis progression was defined as new ≥50% stenosis or ≥30% increase of ≥20% pre - existing stenosis according to coronary angiography (CA) 1 year after CS. Results. Baseline concentration of hsCRP was comparable: 0.21 (0.13; 0.38) vs. 0.20 (0.1; 0.44) mg/dl in groups I and II, respectively (p>0.05). In group I significant hsCRP level decrease to 0.14 (0.07; 0.32) mg/dl (p
Endothelial dysfunction in patients with controlled and uncontrolled arterial hypertension
Authors: Podzolkov V I , Safronova T A , Natkina D U
Published: October 2019

Aim. To conduct a comparative analysis of the level of asymmetric dimethylarginine (ADMA) in two groups of patients with a diagnosis of essential arterial hypertension (AH). Group I - patients with uncontrolled hypertension (UCAH) and group II - patients with controlled course of hypertension (CAH). Materials and methods. The study included 109 patients: group I - 73 patients with UCAH, group II - 36 patients with CAH. Groups were comparable. Clinical, laboratory and instrumental examination was performed, including determination of ADMA concentration in blood plasma. Results. The concentration of ADMA in patients with UCAH was significantly higher than in the group with CAH. In patients with UCAH, a pronounced positive correlation was found between the concentration of ADMA and creatinine level (r=0.615, p
Therapeutic aspects of the choice of antithrombotic therapy in patients with multifocal lesions of peripheral arteries
Authors: Oynotkinova O Sh , Nikonov E L , Kryukov E V , Baranov A P
Published: October 2019

The article discusses the features of the development and course of the atherosclerotic process in various vascular basins. Variability of factors such as local hemodynamics, differences in the structure of the arteries can influence the formation of atherosclerotic plaque and the progression of the atherosclerotic process. A better understanding of the nature and causes of these differences can help improve the tactics of treatment and prevention of vascular complications. Analysis of the results of the COMPASS study (cardiovascular outomes for people using anticoagulation stategies - evaluation of cardiovascular outcomes in patients receiving anticoagulant therapy) showed for the first time the effectiveness of combination therapy using rivaroxaban direct anticoagulant at a dose of 2.5 mg 2 times a day in combination with acetylsalicylic acid at a dose of 100 mg per day. It was shown that, against the background of combination therapy, patients with coronary heart disease or atherosclerotic peripheral artery disease showed a significant decrease in the incidence of events of the primary end point of efficacy: a reduced risk of stroke, cardiovascular mortality and myocardial infarction, and also a reduction in the risk of major lower amputations extremities and total mortality in patients with stable forms of atherosclerosis. The emergence of combination therapy can help to achieve both an improvement in the overall prognosis and the prognosis of limb preservation in patients with multifocal arterial lesion.
Fibrinolytics: from the thrombolysis to the processes of blood vessels growth and remodeling, neurogenesis, carcinogenesis and fibrosis
Authors: Tkachuk V A , Parfyonova Ye V , Plekhanova O S , Stepanova V V , Menshikov M Yu , Semina E V , Bibilashvili R Sh , Chazov E I
Published: October 2019

One of the most outstanding scientific achievements in the thrombolysis is the development and administration of fibrinolysin - the first Soviet drug that lyses blood clots. Intracoronary administration of fibrinolysin reduced the mortality of patients with myocardial infarction by almost 20%. For his work in this field Yevgeny Chazov was awarded the Lenin Prize in 1982. Over the next decades, under his leadership, the Cardiology Center established scientific and clinical laboratories that created new generations of drugs based on fibrinolytics for treating patients with myocardial infarction, restoration of blood flow in ischemic tissue, and also studying the mechanisms of remodeling of blood vessels involving the fibrinolysis system. It have been found new mechanisms of regulation of the navigation of blood vessels and nerves growth, tumor growth and its metastasis with the participation of the fibrinolysis system proteins. The review reports the role of the fibrinolysis system in the thrombolysis, blood vessels growth and remodeling, neurogenesis, carcinogenesis and fibrosis. The article is dedicated to the 90th anniversary of academician E.I. Chazov.
Aflibercept or ranibizumab for the treatment of diabetic macular edema; a retrospective study
Authors: Khlood M. Aldossary  , Anfal Alruzuq  , Ghady Almohanna  , Hessa Almusallam  , Sara Alamri  , Fatima Alshehri  , Arwa Alzahrani  , Attiqa Chaudhary
Published: October 2019

Diabetic macular edema (DME) is a significant cause of diabetic retinopathy and a major cause of vision loss. In this study, we aimed to evaluate and compare the efficacy of two injectable drugs; intravitreal Aflibercept and intravitreal Ranibizumab for the treatment of DME of the eyes. A retrospective chart review was conducted for patients diagnosed with DME from March 2014 to January 2019 who received either intravitreal Aflibercept or intravitreal Ranibizumab injection. A total of 57 eyes were included, of which 19 eyes were treated with intravitreal Ranibizumab injection, and 38 eyes were treated with intravitreal Aflibercept injection; all eyes were examined for 3 months. Two outcomes were assessed in this study, namely; visual acuity (VA) and central macular thickness (CMT). The mean age in the Ranibizumab group was 61.1±9.5 vs 64.3±10.2 in the Aflibercept group with no significant difference (p-value=0.25). The ratio of improvement in visual acuity (VA) in the Ranibizumab group was 68.4% vs 44.7% in the Aflibercept group; (p-value=0.038) which demonstrates the superiority of Ranibizumab over Aflibercept concerning visual acuity result. However, there is no statistically significant difference between the ratio of improvement in central macular thickness (CMT) results in both groups; (p-value=1.00). In fact, the ratio of improvement in CMT in both groups was the same 78.9% for both the groups. The pre and post results demonstrated improvement in post-procedural for CMT among both the groups but only Ranibizumab group showed VA improvement post-procedural. Through this study, we concluded that both injectable drugs improve visual acuity (VA) and decrease central macular thickness (CMT) in eyes with DME. However, Ranibizumab is superior in improving visual acuity compared to Aflibercept. Further comparative effectiveness trials between Aflibercept and Ranibizumab are still warranted.
Cloud point extraction for separation, preconcentration and determination zinc (ii) in different pharmaceutical samples
Authors: Ghusoon Jawad Shabaa
Published: October 2019

Joining solvent extraction with cloud point extraction methods obtained a susceptible method for separation, pre-concentration, extraction and categorization of  Zn (II), after forming an ion-pair association complex between Zn+2 and 4-(3-methyl phenyl azo)-4,5- diphenyl imidazole (MPADPI) with wavelength for maximum absorbance λmax.=496 Nm. This study shows optimum conditions for the formation and exaction ion-pair association complex under pH=9 and 0.5 mL Tritonx-100, 1×10-4 M (MPADPI) and heating at 80 Co for 20 minutes so that this study involved the effect of electrolyte and interferences along with the spectrophotometric determination of Zinc (II) in diverse samples.
Better in solubility enhancement : salt or cocrystal?
Authors: Iyan Sopyan  , Tazyinul Qoriah Alfauziah  , Dolih Gozali
Published: October 2019

Nowadays, most of marketed APIs are in the salt form. But not every single API was ionizable. Thus cocrystallization technique arised to overcome the problem. The aim of this review is to compare the solubility profile of salt and cocrystal. Both salt or cocrystal were used to improve the solubility of APIs and claimed for each other, which is the most effective in solubility enhancement. The salt was formed by ionic interaction, whilst cocrystal formed by hydrogen. Both interactions changed the interaction energy and crystal packing, thus changing the physicochemical properties of APIs. Besides, other factors affecting the solubility of the binary system were melting point, particle morphology, and solubility of coformer. The solubility comparison led to understand the underlying mechanism on solubility enhancement of salt and cocrystal itself.