bluuebunny/crossref_metadata_2025 huggingface dataset:
El sexo de la persona física en Derecho internacional privado
Authors: Hernández Rodríguez Aurora
Published: November 2024

En este trabajo se tratará de analizar cómo y en qué medida el DIPr ha dado respuesta normativa y tratamiento metodológico al sexo y, en su caso, género de la persona física a lo largo de su historia, teniendo en cuenta la propia concepción del sexo imperante en cada época y su evolución desde un sistema de sexo único (el varón) a un sistema binario: sexo-género (hombre/mujer-femenino/masculino). Cuestiones tales como: la condición jurídica de la mujer, y su toma de consideración por parte del DIPr, la teoría de la personalidad de las leyes de Mancini y con ella la pérdida de la nacionalidad de la mujer casada; la reacción y lucha del movimiento feminista a nivel nacional e internacional contra dicho principio o el gran reto que supuso para la doctrina iusinternacionalprivatista el lento pero firme avance del principio de igualdad jurídica y su incorporación a las normas de conflicto, serán objeto de especial atención.
La vinculación indemnizatoria en la conversión de un subagente en agente principal Soberanía estatal, inmuebles transfronterizos y litigación internacional
Authors: Lara González Rafael
Published: November 2024

El artículo 17, apartado 2, letra a), de la Directiva 86/653/CEE del Consejo, de 18 de diciembre de 1986, relativa a la coordinación de los derechos de los Estados miembros en lo referente a los agentes comerciales independientes, debe interpretarse en el sentido de que la indemnización por clientela que el empresario abonó al agente principal en la medida de la clientela aportada por el subagente puede constituir, para el agente principal, una ventaja sustancial. Sin embargo, el pago de una indemnización por clientela al subagente no puede considerarse equitativo, a efectos de dicha disposición, cuando este siga actuando como agente comercial respecto de los mismos clientes y en relación con los mismos productos, pero en el marco de una relación directa con el empresario principal, y ello en sustitución del agente principal que lo había contratado anteriormente.
Strumenti internazionalprivatistici di tutela del lavoratore
Authors: Marino Silvia
Published: November 2024

Il lavoro affronta i principali metodi di diritto internazionale privato al fine di veri-ficarne l’utilizzo e l’efficacia nell’ambito della protezione del lavoratore quale contraente debole nella cooperazione giudiziaria civile. Dopo aver ricordato i principali sviluppi delle fonti normative, il con-tributo esamina la nozione di lavoratore nel diritto dell’Unione europea. Quindi, analizza i tipici metodi della localizzazione e del principio di prossimità, dell’alternatività e della successione dei titoli di giu-risdizione e dei criteri di collegamento, e dei limiti all’autonomia della volontà, come strumenti idonei a garantire una protezione al lavoratore. Per le sue peculiarità, un paragrafo specifico è riservato alla circolazione delle sentenze nello spazio giudiziario europeo.
A propósito del derecho a la asistencia consular de los ciudadanos de la Unión Europea no representados en terceros Estados
Authors: Moreiro González Carlos J.
Published: November 2024

El derecho a la asistencia consular de los ciudadanos de la Unión sin representación de sus autoridades diplomáticas o consulares en un tercer Estado fue consagrado en el Tratado de Maastricht, pero su desarrollo jurídico tuvo lugar posteriormente. Las decisiones intergubernamentales que inicialmente regularon su ejercicio fueron sustituidas por normas supranacionales, actualmente en vigor, que otorgan mayores garantías jurídicas a sus beneficiarios. Recientemente ha comenzado el proceso legislativo para la modificación de dicho marco normativo con vistas a mejorar el ámbito de aplicación y la exigibilidad de la tutela de este derecho por los poderes públicos competentes.
La economía social y las ayudas de estado
Authors: Piernas López Juan Jorge
Published: November 2024

Esta contribución tiene por objeto analizar de qué forma la disciplina de ayudas estatales, en particular la noción de ayuda de Estado con arreglo al artículo 107(1) TFUE, las normas sobre compatibilidad de las ayudas ex artículo 107(2) y 107(3) TFUE y las relativas a los servicios de interés económico general ex artículo 106(2) TFUE, permiten la concesión de apoyo financiero a los agentes de la economía social. El artículo se basa para ello especialmente en los cambios operados en el Derecho primario por el Tratado de Lisboa, la jurisprudencia de los tribunales de la Unión, y la práctica decisoria de la Comisión Europea. Finalmente se incluyen una serie de consideraciones a modo de conclusión.
El contenido de la propuesta de convenio concursal:
Authors: Quijano González Jesús
Published: November 2024

En la evolución histórica del Derecho Concursal el convenio al que puedan llegar el deudor y sus acreedores ha cumplido una función principal de facilitar la conservación de la actividad, generalmente empresarial, afectada por la insolvencia, aunque con frecuencia los procedimientos concursales conducían a la liquidación de la masa activa como solución inevitable. En el Derecho Concursal actualmente vigente en España, tras la reforma de 2022, el convenio ha adquirido una flexibilidad en cuanto a su posible contenido que le hace especialmente útil para resolver situaciones de insolvencia que se estén tramitando como concursos de acreedores, lo que no impide reconocer que la prioridad está hoy en anticipar la solución en la fase preconcursal o de preinsolvencia a través de las técnicas de reestructuración más diversas.
En el presente trabajo se analiza especialmente el contenido que puede tener la propuesta de convenio concursal en nuestro ordenamiento, con especial atención tanto a la variada tipología de supuestos posibles (convenios con quita y espera, con proposiciones adicionales, con modificaciones estructurales), como al conjunto de prohibiciones que constituyen el límite de dicho contenido, sea porque afectan a los créditos, sea porque realmente implican una liquidación.
La adquisición de obras de arte en subastas
Authors: Rodríguez Benot Andrés
Published: November 2024

En el mercado mundial de obras de arte, su adquisición en subastas suscita frecuentes cuestiones relacionadas con el Derecho internacional privado. Dentro de la compleja estructura negocial de la operación, en caso de controversia sobre la compraventa del bien es preciso analizar la determinación de la autoridad competente para conocer del asunto y del ordenamiento aplicable al fondo del mismo, donde adquiere peculiar relieve la lex auctionis.
The economy-wide impacts of different approaches to addressing fuel poverty: the importance of where, when and how public funds are spent
Authors: Turner Karen , Katris Antonios , Corbett Hannah , Higginson Sarah , Zhou Long
Published: November 2024

Depending on the metrics and measurement used, at least 3.6 million UK households currently live in fuel poverty (i). This presents a public policy challenge in terms of reducing both fuel poverty and energy demand in ways that are positive for the wider economy, that support employment and income generation, and do not introduce price pressures which further affect the cost of living and doing business. Within the Energy Demand Research Centre (EDRC), the Equity theme has explored the impact of different ways of using of a £9 billion public funding pot, aimed at closing the fuel poverty gap on an annual basis between 2025 and 2030(ii). This figure was arrived at in the following way. The fuel poverty gap is defined by ONS (iii) as the amount of money a household needs to no longer be considered as living in fuel poverty. This amount was estimated by DESNZ (iv) at £417 for 2023, the last year for which an estimate is available. If £417 is allocated to help 3.6 million households for the 6 years between 2025 and 2030, the total pot required is £9 billion. We used an economy-wide model to simulate scenarios where this public funding pot is (a) channelled as a direct energy bill support to 3.6 million UK households in fuel poverty under the English definition or (b) used to fund basic energy efficiency measures for as many homes as possible
The Effect of Smoking Duration and Daily Consumption on Anxiety and Sleep Quality in Smokers
Authors: Çökmen Asiye , Yılmaz Kamil , Akkoyun Sert Özlem
Published: November 2024

Objective: Our aim is to compare the anxiety and sleep quality levels of smokers and non-smokers and to investigate the relationship between smoking duration and daily consumption amounts with anxiety and sleep quality.
Materials and Methods: Eighty individuals, between the ages of 18 and 50, with a mean age of 31.98±10.31 years were participated in the study. Participants were divided into two groups as smokers (n=40) and non-smokers (n=40). The smoker group was divided into two groups as the one smoking less than half a pack (n=20) and the other smoking more than one pack (n=20). Anxiety was evaluated with the Beck Anxiety Inventory (BAI) and sleep quality with the Pittsburg Sleep Quality Index (PSQI).
Results: It was found that the anxiety level of the smoker group was higher and the sleep quality values were lower than the control group (p<0.001). There are relationships among the smoking duration, the amount of cigarette consumption (r = -0.530 , p<0.001) and anxiety (r =0.381 , p=0.015), between the amount of cigarette consumption and anxiety (r = -0.384 , p=0.014) and between the sleep quality and the anxiety (r=0.546 , p<0.001).
Conclusion: Smoking causes an increase in the level of anxiety and a decrease in sleep quality. As the smoking duration increases, the anxiety score increases and as the anxiety level increases, the sleep quality decreases.
Fizyoterapi ve Rehabilitasyon Eğitiminde Farklı Kurumlarda Görev Alan Akademisyenlerin Web 2.0 Araçlarına Yönelik Davranışlarının ve Kullanım Sıklığının Değerlendirilmesi
Authors: Kolaylı Tuba , Doğan Mert , Aksu Yıldırım Sibel
Published: November 2024

Amaç: Teknolojik yeniliklerin hayatımızda kendini gösterdiği alanlardan biri de eğitimdir. Yaşanan gelişimlerle birlikte yükseköğretimde yeni teknolojilerin geleneksel öğretime dahil edilmesi kaçınılmazdır. Bu noktada Web 2.0 araçlarının eğitime entegre edilmesi ve sıklıkla kullanılması önemlidir. Web 2.0 araçlarının eğitimdeki rolünü etkileyen en önemli unsurlardan biri akademisyenlerin tercihleridir. Bu araştırmanın amacı ülkemizde Fizyoterapi ve Rehabilitasyon eğitiminde görev alan akademisyenlerin Web 2.0 kullanımını analiz etmek ve göstermektir.
Gereç ve Yöntem: Literatürde yer alan Web 2.0 araçlarını içeren bir değerlendirme formu araştırmacılar tarafından oluşturuldu. Türkiye’de Fizyoterapi ve Rehabilitasyon Bölümü’nde aktif olarak eğitim veren akademisyenlerden demografik bilgi formu ile araştırmacılar tarafından hazırlanan değerlendirme formunu cevaplamaları istendi. Akademisyenlerin cevapları ‘Google Forms’ üzerinden kaydedildi.
Bulgular: Çalışma, araştırma görevlisi (%32), öğretim görevlisi (%20), doktor öğretim üyesi-doktor (%23), doçent (%12) ve profesör (%11) olmak üzere toplamda 130 akademisyenin katılımıyla tamamlandı. Akademisyenler tarafından en çok tercih edilen Web 2.0 aracı ‘Zoom’(%96,25) olurken en az tercih edilen araç (%5,4) ile ‘Genially’ olarak belirlendi. Akademisyenlerin büyük çoğunluğunun Padlet (%83), Mindmeister (%92), edX (%88) ve Camtasia (%87) araçlarını hiç tercih etmediği bulundu.
Sonuç: Genel olarak ortak çalışma alanı oluşturma, içerik geliştirme, veri toplama, interaktif soru araçları, eğitim platformu ve sosyal medya araçlarının akademisyenler tarafından eğitimde kullanılma oranları düşüktü. ‘Youtube’, ‘Google Forms’ ve ‘Zoom’ uygulamalarının ise sıklıkla tercih edildiği görüldü. Bu çalışmanın sonuçları Fizyoterapi ve Rehabilitasyon eğitiminde akademisyenlerin Web 2.0 aracı kullanımlarının geliştirilmesi gerektiğini göstermektedir.
Sağlıklı Bir Kişide Mental Yorgunluk Dengeyi Bozar Mı?
Authors: Demircan Emine Nur , Ruşen Ece , Köse Nezire
Published: November 2024

Amaç: Günlük yaşamda hiçbir denge bozukluğu yaşamayan sağlıklı bir kişinin iş yaşantısı sırasında yaşadığı denge bozukluğunun nedeninin mental yorgunluk olup olmadığını belirlemek amacıyla bu çalışma yapıldı.
Gereç-Yöntem: Denge bozukluğu nedeniyle bölümümüze başvuran 24 yaşındaki sağlıklı kadın danışanın, günlük yaşamda hiçbir denge bozukluğu olmadığı, ancak çok yoğun olan iş günleri sırasında denge problemi yaşadığı, yapılan tüm tıbbi incelemelerinde hiçbir olumsuz sonuç bulunmadığı öğrenildi. Alınan hikâyeden sonra ilk olarak bireye alt ekstremite kas kuvveti ve enduransı, propriosepsiyon, bilişsel durum ve denge değerlendirmeleri yapıldı. Daha sonra Sözel Bellek Süreçleri Testi ve Hayvan-KAS Testi ile kişide Mental Yorgunluk (MY) oluşturuldu, arkasından tüm değerlendirmeler tekrar edildi. Bir gün sonra da aynı işlemler, denge testleri ek bir görev ile yaptırılarak tekrar edildi. Böylece denge testleri hem biraz daha zorlaştırılmış hem de ikili görevin denge aktivitesi ile bilişsel durum üzerindeki etkisi de incelenmiş oldu.
Bulgular: Çalışma sonunda MY ile kişinin statik ve dinamik dengesinin olumsuz yönde etkilendiği, ek bir görev ile yapılan denge aktivitesinde dengenin daha da bozulduğu, ilave olarak bu aktivite sonrasında bilişsel işlevin de azaldığı, ayrıca MY sonrası, bireyin kas kuvveti, endurans ve propriyosepsiyon yönünden daha zayıf olan ekstremitesi üzerinde durma dengesinin daha da bozuk olduğu belirlendi.
Sonuç: Çalışma sonunda; kişilerde tıbbi açıdan denge problemi oluşturabilecek bir problem olmasa da MY’nin ve ikili görev aktivitelerinin denge üzerinde olumsuz etki oluşturabileceği, alt ekstremite kas kuvveti, enduransı ve propriyosepsiyonun da MY’e ek olarak dinamik denge üzerinde olumsuz etkiyi artırabileceği sonucuna ulaşıldı. Bundan yola çıkarak sağlıklı yetişkinlerde denge gerektiren günlük yaşam aktiviteleri ve egzersiz programları planlanırken MY, bilişsel durum, kas kuvveti, endurans ve propriyosepsiyon duyusunun göz önünde bulundurulması gerektiği kararına varıldı.
Etkileşimli Kitap Okumanın Gelişimsel Dil Bozukluğuna Etkileri: Ön Çalışma
Authors: Karahan Tığrak Tuğçe , Özcebe Esra
Published: November 2024

Amaç: Bu çalışma, gelişimsel dil bozukluğu olan çocukların dil ve konuşma terapilerine ek olarak etkileşimli kitap okuma ile karşılaşmaları sonucunda dil ve öz düzenleme becerilerinde nasıl bir farklılık olacağını belirlemek amacıyla yapılmıştır.
Gereç ve Yöntem: Gelişimsel dil bozukluğu olan kontrol grubunda bulunan 48-72 ay arasındaki 10 çocuğa standart dil ve konuşma terapisi uygulandı. Çalışma grubunda bulunan 10 çocuğa ise dil ve konuşma terapisi yanı sıra etkileşimli kitap okuma uygulandı. Çocuklara 8 hafta boyunca dil konuşma terapisi ve/veya etkileşimli kitap okuma uygulandı. Çocukların hem dil becerileri hem de öz düzenleme becerileri müdahale öncesi ve sonrasında parametrik olmayan analizler ile incelendi.
Bulgular: Dil ve konuşma terapisine ek olarak etkileşimli kitap okuma müdahalesi alan gelişimsel dil bozukluğu olan çocukların dil becerileri ile öz düzenleme becerilerine dair dikkat dürtü kontrol boyutu daha fazla ilerleme göstermiştir.
Sonuç: Gelişimsel dil bozukluğu olan çocukların yaşadığı bilişsel zorluklarının gözden kaçırılmaması için dil ve konuşma terapisi müdahale planlarında düzenlemeler yapılmalıdır. Bu çocukların sadece dil zorluğu değil öz düzenleme becerileri için de etkileşimli kitap okumanın uygun bir öneri olduğu düşünülmektedir.
Does Smart Phone Usage in Young Adults Have an Effect on Static and Dynamic Balance?
Authors: Özdemir Kadirhan , Dönmez Batuhan , Zeren Melih , Yürekdeler Şahin Nilay , Karakurum Eshan , Eroğlu Rumeysa
Published: November 2024

Objectives: This study aimed to investigate the effects of talking and note-taking on a smartphone on static and dynamic balance.
Materials and Methods: In the study, healthy young adults (n=36) were asked to maintain postural balance while standing on static and dynamic platforms in different tasks: (Task I) without using a smartphone, (Task II) while taking notes on a smartphone, and (Task III) while talking on a smartphone. Center of pressure (CoP) on mediolateral (CoPx) and anteroposterior (CoPy), CoP path length, CoParea, and trunk deviation length were used to measure static and dynamic postural balance.
Results: On a static platform, CoPy and CoParea were different between the tasks (p<0.001, p=0.017). Task II and Task III impaired CoPy more than the task I (p<0.001, p=0.004). Task III affected CoParea more negatively than task II (p=0.027). CoP path length was lower in task II and task III (p<0.001). CoP path length was significantly higher in task III compared to task II (p<0.001). On a dynamic platform, there were differences in CoPy between the tasks (p=0.038). There was a difference in CoPy between task II and task III (p=0.005). The CoParea was significantly different between the tasks (p=0.023). CoParea and CoP path length was higher in task II compared to task I (p=0.035, p<0.001).
Conclusion: The study showed that smartphone use during specific tasks, including talking and/or note-taking on a smartphone, could increase the risk of falls and accidents by affecting center of pressure and postural sway.
Determining the Relationship Between Frailty and Fall Risk in Elderly People Living in Nursing Homes
Authors: Şişman Hamide , Alptekin Dudu , Dağlı Elif
Published: November 2024

Objective: The study aimed to determine the relationship between the level of frailty and the risk of falls in the elderly living in nursing homes and to draw attention to this issue.
Method: The cross-sectional and descriptive study was conducted in two state-owned nursing homes in Adana between January 2, 2023, and January 15, 2023. The study was conducted by face-to-face interviews with a total of 220 elderly people who met the research criteria and agreed to participate in the study. Data were collected using the Personal Information Form, Itaki Fall Risk Index, and Edmonton Frailty Scale.
Results: 63,6% of the participants were women, and the average age was 76±8 (min=60, max=98). Female gender (58,3%), normal BMI (54,9%), lack of regular exercise (85,4%), presence of chronic disease (55,6%), use of assistive devices (85,6%), history of falling A statistically significant relationship was found between (63,9%) and hospitalization history (61,1%) and fall risk level (p<0.05). Normal BMI (60%), lack of regular exercise (70%), presence of chronic disease (70%), number of medications used 1-3 (55%), use of assistive devices (97,5%), history of falling (100%), a statistically significant relationship was found between the history of hospitalization (72,5%) and the risk level of severe frailty (p<0,05). A statistically significant relationship was found between frailty level and fall risk (p = 0,00).
Conclusion: Elderly people with moderate and severe frailty were found to be at high risk of falls.
Hamilelerde Yenidoğan İşitme Taraması ve Risk Faktörleri Farkındalığı
Authors: Baş Banu , Akdemir Gülse , Biber Elif Zehra
Published: November 2024

Amaç: Hamile bireylerin işitme kaybında erken müdahalenin önemine, yenidoğan işitme tarama programına (YDİTP) ve tarama sürecinin işleyişine, işitme kaybının çocuk üzerindeki etkilerine yönelik bilgilerinin ve farkındalıklarının ortaya çıkarılmasıdır.
Gereç ve Yöntem: 18 sorudan oluşan farkındalık değerlendirme soruları YDİTP’nin içeriği, risk faktörleri, ebeveynin kendine olan güveni, tanısal süreç, işitme kaybının etkileri gibi konulardan oluşmaktadır. Farkındalık değerlendirme sorularında beşli likert ölçek kullanılmıştır.
Bulgular: Çalışmaya katılan 113 hamile bireyin %74’ü işitme kaybı risk faktörleri ve YDİTP hakkında farkındalık sorularına “Katılıyorum” yanıtı vermiştir. Gebelik ilk yarısı ve son yarısında olanların farkındalık oranlarında anlamlı bir fark çıkmadığı gibi farklı eğitim seviyelerinde olanlar arasında da fark çıkmamıştır. Ancak en az bir çocuğu olanların farkındalık seviyesi hiç çocuğu olmayanlardan yüksek bulunmuştur.
Sonuç: Bebeğe bakım verenlerin işitme sağlığı konusunda bilinçli olması taramanın başarısı açısından önemlidir. Özellikle annelerin farkındalıklarının ve motivasyonunun yüksek olması erken tanı ve erken müdahalede etkili bir faktördür.
Concomitant Arthroscopic Superior Labral and Rotator Cuff Repair
Authors: Rowe Dana G. , Hurley Eoghan T. , Bethell Mikhail A. , Doyle Tom R. , Meyer Alex M. , Lorentz Samuel G. , Klifto Christopher S. , Lau Brian C. , Dickens Jonathan F.
Published: November 2024

Background:

The aim of this study was to systematically review the literature on concomitant repair of superior labral and rotator cuff tears, in light of the paucity of published clinical evidence.

Methods:

A Preferred Reporting Items for Systematic Reviews and Meta-Analyses compliant search of PubMed, Embase, and Cochrane Library databases was performed for clinical studies of patients undergoing combined repairs of the rotator cuff and superior labrum.

Results:

Ten studies comprising 241 shoulders were included, with a mean age of 52.6 years and mean follow-up of 29.0 months; 67.9% were male patients. Functional outcomes included the mean postoperative American Shoulder and Elbow Surgeons Standardized Shoulder Score of 88.6, University of California at Los Angeles Shoulder Score of 30.6, constant score of 90.4, Simple Shoulder Test score of 8.6, and visual analog scale score of 1.1. Range of motion outcomes demonstrated mean postoperative forward flexion of 159°, external rotation of 68°, and internal rotation of 17°. The overall return-to-play rate was 76.8%, with 67.9% returning to preinjury level. The overall complication rate was 4.1% with an 18.9% rate of rotator cuff retear and 2.4% reoperation rate.

Conclusion:

Arthroscopic concomitant repair of superior labral and rotator cuff tears results in good functional outcomes and range of motion, along with a low reoperation rate. Among athletes, there are moderate rates of return but lower rates of return to the same level of play.

Level of Evidence:

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Improving aquatic placement practices for beneficial use of dredged material in the Great Lakes
Authors: Miller Jennifer , Theiling Charles , McQueen Andrew , McFall Brian , Krafft Douglas , Hayhurst Brett , Unghire Joshua , Hannes Andrew , Hinterburger Bryan , Selegean James , Bosman Melissa , Suedel Burton , Keil Karen
Published: November 2024

The Great Lakes Navigation System is an economically critical waterway. To maintain safe and navigable waterways, approximately 3–5 million yd³ (2.3–3.8 million m³) of sediments are dredged annually. The US Army Corps of Engineers (USACE) and others now recognize that beneficial use of these sediments can achieve positive economic, environmental, and social outcomes. However, historically less than 25% of dredged sediments have been beneficially used in the nearshore environment. Improvements are needed in dredged material management practices in the Great Lakes to achieve the goal of using 70% of dredged sediments beneficially by 2030. Therefore, to overcome these challenges this report reviews beneficial use of dredged material projects with the goal of improving and in-creasing beneficial-use-placement practices in the Great Lakes. Identified needs to advance beneficial-use placement in the Great Lakes include the following: (1) improved modeling of sediment-placement methods; (2) better documentation regarding the cost, benefits, and drawbacks of various placement methods; (3) demonstration of some sediment-placement techniques used successfully in other coastal environments; and (4) monitoring before and after conditions, particularly for sediments that contain greater than 10% fines. Several demonstration projects should be implemented to obtain information addressing the data gaps.
Cautiously optimistic about data-driven algorithms in paediatric critical care, nurses’ perspectives in low-resource settings: a pre-implementation and human-centred design study in Malawi
Authors: Rakers Margot , Mwale Daniel , de Mare Lieke , Chirambo Lezzie , Bierling Bart , Likumbo Alice , Langton Josephine , Team IMPALA Study , Chavannes Niels , Os Hendrikus van , Calis Job , Dellimore Kiran , Villalobos-Quesada María
Published: November 2024

Introduction
Paediatric critical care nurses face challenges in promptly detecting patient deterioration and delivering high-quality care, especially in low-resource settings (LRS). Patient monitors equipped with data-driven algorithms that integrate monitor and clinical data can optimise scarce resources (e.g. trained staff) offering solutions to these challenges. Poor algorithm output design and workflow integration are important factors hindering successful implementation. This study aims to explore nurses' perspectives to inform the development of a data-driven algorithm and user-friendly interface for future integration into a continuous monitoring system for critical care in LRS.
Methods
Human-centred design methods, including contextual inquiry, semi-structured interviews, and co-design sessions, were carried out at the high-dependency units of Queen Elizabeth Central Hospital and Zomba Central Hospital in Malawi. Triangulating these methods, and employing qualitative content analysis principles, we identified what algorithm could assist nurses and used co-creation methods to design a user interface prototype.
Results
Workflow observations demonstrated the effects of personnel shortages and limited monitor equipment availability for vital sign monitoring. Interviews emphasised the advantages of predictive algorithms in anticipating deterioration, underlining the need to integrate the algorithm’s output, the (constant) monitoring data, and the patient's present clinical condition. Nurses preferred a scoring system represented with familiar scales and colour codes. During co-design sessions, trust, usability and context specificity were emphasized as requirements for these algorithms. Four prototype components were examined, with nurses favouring explainable and transparent scores represented by colour codes and visual representations of score changes.
Conclusions
Nurses in LRS perceive that data-driven algorithms, especially for predicting patient deterioration, could improve the provision of critical care. This can be achieved by translating nurses' perspectives into design strategies, as has been carried out in this study. The lessons learned are summarised as actionable pre-implementation recommendations for the development and implementation of data-driven algorithms in LRS.
Health facility revisit and its associated factors among clients utilizing public health facilities in Zanzibar
Authors: Abdul Ramadhani , Bajaria Shraddha , Haji Abdul-Latif , Mselem Mwinyi , Marwa Heri , de Wit Tobias F. Rinke , Risha Peter , Dieteren Charlotte
Published: November 2024

Background
Since 1964, healthcare in Zanzibar has been funded by the government through taxes and is free for all at all points of care. As this system is financially unsustainable, Zanzibar’s healthcare system is undergoing a reform. The current inadequate funding allocation and poor adherence to the referral system lead to an inefficient health system. To gain insights into how precisely inefficient healthcare utilization is concentrated within the Zanzibar healthcare system, we used the capabilities of a relatively new digital healthcare reporting system that uses individual patient-level information. This study determined the magnitude of patient revisits to health facilities and analyzed the factors associated with these revisits.
Methods
This longitudinal prospective study included all clients enrolled in Zanzibar’s digital healthcare utilization system and who had at least one public health facility visit between January 2021 and June 2022. Revisit was defined as revisiting any public health facility within the study period. The time taken to revisit a health facility was calculated as the difference in days between the consecutive multiple visit dates. We applied logistic and lineair regression models to assess the factors associated with revisits to health facilities.
Results
Of the 554,264 enrolled clients, 45,675 (8.2%) visited a health facility during the 18-month study period, of which 28.3% had revisited. Of these, 86.8% revisited the same facility, whereas the rest visited multiple different facilities. Over 10% of the revisit patients had a revisit within ten days. Children under five years of age, females, individuals with higher socio-economic status, those insured, and those diagnosed with non-communicable diseases (NCDs) were more likely to revisit. In addition, patients diagnosed with NCDs, non-residents, children under five years of age, and individuals with a low socioeconomic status were most likely to revisit a health facility within a short time window. Undiagnosed conditions were common at lower-level facilities.
Conclusion
The findings suggest a need to enhance the effectiveness and efficiency of health services delivery, especially at lower levels, to reduce avoidable revisits and consequently reduce the cost per patient. The findings can also be used as a resource to inform ongoing healthcare reform in Zanzibar.
Solubility of ʟ-arginine in twelve mono-solvents: Solvent effects, molecular simulations and model correlations
Authors: Xiao Yusheng , Hu Shen , Zhao Long , Xing Xin , Li Junjie , Ding Min , wang Peng , Li Bingbing
Published: November 2024

The solubility data of ʟ-arginine were measured by the static gravimetric method in twelve mono-solvents (water, methanol, ethyl acetate, ethanol, n-hexane, 2-butanone, isopropanol, 2-butanol, dichloromethane (DCM), dimethylformamide (DMF), 1,4-dioxane and acetonitrile) at T = 283.15-323.15 K and P = 101.2kPa. In the solvents used, solubility increases with increasing temperature. The solubility order of ʟ-arginine at 298.15 K in 12 mono-solvents was ranked as: water > methanol > ethyl acetate > ethanol > n-hexane > 2-butanone > isopropanol > 2-butanol > DCM > DMF > 1,4-dioxane > acetonitrile. According to the results, among the factors affecting the dissolution behavior, Dimroth and Reichardt’s polarity parameters (ET(30)) plays a dominant role, and is also affected by hydrogen bond and cohesive energy density. Molecular modeling including Hirshfeld surface (HS) analysis and molecular electrostatic potential surface (MEPS) were employed to understand internal interactions within ʟ-arginine crystals. The results of interaction region indicator (IRI) and interaction energy show that the solubility of ʟ-arginine in the selected alcohol solvents decreases with the growth of the solvent carbon chain The modified Apelblat model, Yaws model and the Margules model can be well used to correlate the solubility data. Moreover, The Akaike information criterion method was used to evaluate the fitting accuracy of the three models. The evaluation results show that the Yaws model is more suitable for this work. This study enriches the solubility data of ʟ-arginine and provides basic data for the production application of ʟ-arginine.
Deep Generative Optimization of mRNA Codon Sequences for Enhanced Protein Production and Therapeutic Efficacy
Authors: Xie Zhi , Li Yupeng , Wang Fan , Yang Jiaqi , Han Zirong , Chen Linfeng , Jiang Wenbing , Zhou Hao , Li Tong , Tang Zehua , Deng Jianxiang , He Xin , Zha Gaofeng , He Yao
Published: November 2024

Messenger RNA (mRNA) therapeutics show immense promise, but their efficacy is limited by suboptimal protein expression. Here, we present RiboCode, a deep learning framework that generates mRNA codon sequences for enhanced protein production. RiboCode introduces several advances, including direct learning from large-scale ribosome profiling data, context-aware mRNA optimization and generative exploration of a large sequence space. In silico analysis demonstrate RiboCode’s robust predictive accuracy for unseen genes and cellular environments. In vitro experiments show substantial improvements in protein expression, with up to a 72-fold increase, significantly outperforming past methods. In addition, RiboCode achieves cell-type specific expression and demonstrates robust performance across different mRNA formats, including m1Ψ-modified and circular mRNAs, an important feature for mRNA therapeutics. In vivo mouse studies show that optimized influenza hemagglutinin mRNAs induce ten times stronger neutralizing antibody responses against influenza virus compared to the unoptimized sequence. In an optic nerve crush model, optimized nerve growth factor mRNAs achieve equivalent neuroprotection of retinal ganglion cells at one-fifth the dose of the unoptimized sequence. Collectively, RiboCode represents a paradigm shift from rule-based to data-driven, context-sensitive approach for mRNA therapeutic applications, enabling the development of more potent and dose-efficient treatments.
Comprehensive genome-wide identification and expression profiles of SAUR family genes in Fagopyrum tataricum
Authors: Yuan Yi , Qi Huanhuan , Zou Juan , Gui Zihao , Li Yun , Zu Qihang , Gao Yingying , Feng Chenglu , Dong Guoqing , Du Dengxiang
Published: November 2024

Background
Plant development and environmental adaptation are intricately regulated by hormones, with auxins playing a pivotal role in these processes. Within the auxin response family, the Small Auxin Up-regulated RNAs (SAURs) family holds a significant position in controlling plant development and responding to abiotic stress. However, investigations into this family in tartary buckwheat (Fagopyrum tataricum)are still lacking. The whole genome sequence of buckwheat offers a precious opportunity for comprehensive research on the genome-wide expression profile of the SAURs family.
Results
Based on the SAUR domain, 95 FtSAURs genes were identified in buckwheat. Additionally, the structure, evolution, and expression patterns of FtSAURs members were also analyzed. The FtSAURs genes exhibit diverse expression profiles across various developmental tissues and stages, revealing 27 tissue-specific expression genes and 35 hormone-responsive genes. Furthermore, under drought and salt stress conditions, 19 and 13 genes with current changes were detected, respectively. Notably, genes like FtSAUR30 have undergone significant changes after treatment, emerging as potential candidates for stress response.
Conclusions
Our research lays a valuable foundation for further analysis of the abiotic stress resistance mechanism in buckwheat.
WITHDRAWN: Translation of Code-Mixed and Code-Switched Tweets Using LLMs for Enhanced Sentiment Analysis Outcomes
Authors: Sharma Durga , Johari Rahul , Gupta Kalpana
Published: November 2024

The full text of this preprint has been withdrawn by the authors while they make corrections to the work. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Assessment of Atherogenic Risk indices and Dyslipidemia in Libyan Smokers
Authors: Alemam Hafsa , Mustafa Ariej , Shebani Afaf , Attayeb Marwa , Akarem Abdurrahman , Elzagheid Adam , Eltaib Farag
Published: November 2024

Background
The atherogenic index of plasma (AIP) is a novel indicator for assessing the risk of atherogenicity and cardiometabolic health. The study was aimed to investigate the correlation between smoking behaviours and atherogenic indices among cigarettes smokers.
Methods
The study was conducted at the Libyan Biotechnology Research Centre in Tripoli, Libya. Two hundred Libyan male subjects were divided into two groups: a group of smokers and a group of non-smokers (as the control group). After an overnight 12-hour fast, five millilitres of fasting whole blood were collected for analysis. Plasma lipid profiles, including total cholesterol (TC), triglycerides (TGs), low-density lipoprotein (LDL), and high-density lipoprotein (HDL), were assessed, and levels of atherogenic index of plasma (AIP) were determined.
Results
The results of the study showed that the smokers' group had significantly elevated levels of total cholesterol (TC), triglycerides (TGs), and low-density lipoprotein (LDL) compared to the non-smokers. Interestingly, all smoker participants exhibited AIP levels greater than 0.1, indicating an increased risk of atherogenicity. In contrast, only 15% of the control group had AIP levels indicating intermediate risk, while the remaining 85% had low risk.
Conclusion
Based on these findings, the study concluded that there is a significant association between smoking and atherogenic indexes. It also suggested that AIP may serve as an alternative screening tool in situations where all other atherogenic parameters are normal.
Research on Automatic Generation Method of Spiral Cooling Channel for Injection Mold Based on Spring Model
Authors: Wang Jing , Cheng Fangqi
Published: November 2024

The conformal cooling channel is increasingly favored by mold enterprises for its excellent cooling effect, and more and more designers are using conformal cooling channel in mold design cases. Among numerous cooling channel structures, spiral cooling channel is a very typical and widely used channel structure. Due to its free and flexible spiral shape, designing this channel is not an easy task. For a long time, designers can only rely on basic modeling tools to complete design work through a large number of interactive operations, which often requires a lot of time and effort. Inspired by the spring structure, this paper proposes an automatic generation method for spiral cooling channel. Its basic idea is to first project the spiral line onto the offset surface of the mold surface through the projection curve method, thereby obtaining the initial trajectory line. Then, control points are generated on the initial trajectory line, and finally, spline curves are used to string all control points together to form a scanning trajectory line, and scan along the scanning trajectory line with the specified cross-section to form a cooling channel. Experimental results show that this method is simple and practical, and can quickly generate spiral cooling channels that meet the requirements, greatly saving design time, reducing design errors, and improving design efficiency.
Cytological Observation of Distant Hybridization Barrier and Preliminary Investigation of Hybrid Offspring in Tea Plants
Authors: Mo Xiaoli , Wang Yihao , Huang Yahui , Yan Changyu , Zeng Zhen
Published: November 2024

This study focuses on the reproductive barriers of distant hybridization in Camellia sinensis and the characteristics of its hybrid offspring. As a crop with significant economic value, the leaves of Camellia sinensis are not only widely popular for making tea but also have various health benefits. However, although wild tea germplasm resources have unique functional components, their processing quality is often not satisfactory. To improve tea plant varieties, this study employs distant hybridization techniques to break through species boundaries and increase genetic variation, with the aim of cultivating new varieties with superior quality. In this study, utilizing Camellia sinensis cv. Jinxuan as the maternal parent, C. gymnogyna Chang and C. sinensis cv. Yinghong No.9 as the paternal parents, interspecific distant hybridization (DH) and intraspecific hybridization (IH) were conducted. The study found that the pollen tubes of the distant hybridization combinations (DH) grew rapidly in the early stages after pollination, but their growth was hindered upon reaching the base of the style, making it difficult to combine with the ovules to complete fertilization. Despite the barriers, some pollen tubes successfully fertilized, and the early stages of embryo development were normal after fertilization. However, the high rate of fruit drop and low seed germination rate in the distant hybrid offspring limited the success of distant hybridization. A study of the phenotype and biochemical components of 30 offspring obtained from successful distant hybridization revealed that the offspring exhibited rich genetic diversity in both phenotype and biochemical composition. Although distant hybridization has a certain degree of affinity, the problem of fruit drop in the later stages severely affects the success of hybridization. To obtain more distant hybrid offspring, it is recommended to adopt embryo rescue techniques. This study not only provides important theoretical and practical basis for the distant hybridization of tea plants but also offers new ideas and methods for improving tea plant varieties and enhancing the economic benefits of tea production. Through in-depth research on the distant hybrid offspring, it is expected to cultivate new tea varieties with better quality and stronger adaptability.
Enhancing Security in CPS Industry 5.0 Using Lightweight MobileNetV3 with Adaptive Optimization Technique
Authors: Aleisa Mohammed A.
Published: November 2024

The Industrial Revolution of technologies such as the Industrial Internet of Things (IIoT), cloud and Artificial Intelligence (AI) is breaking new frontiers in industrial process automation. Under the Industry 5.0 revolution, AI based manufacturing units are more sophisticated Cyber-Physical Systems (CPS) that allow the interaction of people, objects and machines at any given supply chain level. One of the key advantages of this transformation is that it enables implementing individual-focused and adaptable manufacturing systems. However, this interconnection poses various threats, especially the phenomenon referred to as attacks that are sophisticated in nature sometimes known as distributed denial of service (Ddos) attacks. In the quest to prevent cyber security challenges in the CPS Industry 5.0, this paper proposes a simple and effective System based on Deep Learning architecture. The very first stage concerns data acquisition which entails careful monitoring and collection of raw data from inbuilt sensors for real time performance. In this case, the data is also processed further in order to clean the data, handle missing values within the data set and fix any errors present in the data set, improving it. The next step involves Normalization and feature extraction which takes on the shape of reducing the data into shapes acceptable by the key features; flow-based, time-based and statistical features as well as deep features using ResNet-101. To process the models, MobileNetV3 which are light weight models of deep learning, are predicted to be utilized in the edge devices that are low in resources through quantization and pruning methods. This quantization and pruning is going to reduce the weight of the model or data. The efficient local search method CTPOA is applied for adjustment of parameters, data optimization and performance improvement of the model. Finally, the data in the CPS is safeguarded by the use of AES encryption and Discretionary Access Control policies.
Machine Learning-Based Prediction of Soil Compaction Parameters
Authors: Senturk Muharrem Atakan , Ordu Ertugrul , Tan Rabia Korkmaz
Published: November 2024

This study aims to predict the soil compaction parameters maximum dry density (MDD) and optimum moisture content (OMC) using machine learning models. As a result of this aim, fast and much less costly advanced machine learning models can be used as an alternative to traditional methods such as proctor test, which are time-consuming and costly in geotechnical engineering. The study conducts a comparative analysis of various machine learning models such as decision tree, random forest, gradient boosting and group method of data handling (GMDH) to determine the most accurate and efficient model. As a result of this comparative analysis, the random forest model was the most successful model. According to the 5-fold cross-validation results of the random forest model, the average training coefficient of determination (R²) value is 0.95 and the average testing R² value is 0.71. Surely, if we had a dataset with more data, higher performance results could be achieved with existing machine learning models. The results obtained demonstrate that machine learning models increase project efficiency and reduce costs by reducing reliance on laboratory testing, and offer an approach with the potential to improve soil compaction applications in geotechnical engineering.
Factors Association with Experience of Violence Across Generation Ages: A Gender-based Analysis
Authors: Yomai Korravarn , Charupoonphol Phitaya , Taechaboonsermsak Pimsurang , Fongsatitkul Prayoon , Pitikultang Supachai , Munsawaengsub Chokchai , Sresumatc Vanvisa , Thongworn Sittichai
Published: November 2024

Background Violence is a critical public health issue that impacts the physical, metal, and social well-being of individuals and community, necessitating comprehensive prevention and intervention strategies. a
Methods This cross-sectional survey aims to assess the experience of violence among Thai families and to determine the factors associated with violence across difference generation. A total 6,000 subjects were randomly selected from twelves provinces across six regions of Thailand. Respondents were interviewed using a structured questionnaire administered by well-trained data collectors. Data analysis was conducted using logistic regression to determine the significant predictors of violence within families.
Finding The prevalence of violence was 11.9%, 7.8%, 7.0%, and 5.2% across Generation Z, Generation Y, Generation X, and Baby Boomers, respectively. This study examines factors influencing experiences of violence across generational cohorts. Among Generation Z, non-traditional family structures (OR = 2.30, 95% CI [1.30-4.03]), residing with substance abusers (OR = 1.64, 95% CI [1.13-2.63]), inadequate family income (OR = 1.98, 95% CI [1.26-2.89]), low family strengths (OR = 2.56, 95% CI [1.58-4.16]), and poor violence literacy (OR = 4.78, 95% CI [2.43-9.39]) were significant factors. In Generation Y, being single (OR = 2.20, 95% CI [1.53-3.15]), family income sufficiency (OR = 1.50, 95% CI [1.03-2.19]), moderate (OR = 1.57, 95% CI [1.08-2.28]) and poor family strengths (OR = 3.12, 95% CI [1.77-5.49]), and moderate (OR = 1.52, 95% CI [1.01-2.28]) and poor violence prevention literacy (OR = 3.55, 95% CI [1.53-8.22]) were influential. Generation X was notably affected by residing with substance abusers (OR = 1.46, 95% CI [1.02-2.09]), while Baby Boomers experienced impacts from poor violence prevention literacy (OR = 3.03, 95% CI [1.09-8.41]) and moderate community prevention measures (OR = 1.92, 95% CI [1.03-3.59]). Additionally, across each generation, these factors demonstrate divergent correlations with experiences of violence based on gender.
Discussion This study highlights that experiences of violence differ across generations, shaped significantly by gender norms with each era. Furthermore, that factors influencing these experiences vary distinctly among different age cohort. Each generation exhibits unique attitudes, ideologies, and lifestyles, necessitating customized approaches for violence prevention. Addressing these differences is crucial as societal transitions impact health outcomes and experiences differently across generations.