bluuebunny/crossref_metadata_2025 huggingface dataset:
Studi Evaluatif: Tingkat Kepatuhan Pasien Pasca Stroke Rawat Jalan RSUD Taman Husada Kota Bontang
Authors: Fauzi Lailla Affianti , Maria Regina , Anwar Adliah
Published: August 2024

Kepatuhan pasien dalam mentaati rekomendasi pengobatan stroke menjadi salah satu faktor yang mempengaruhi kejadian keterulangan stroke. Kepatuhan terhadap obat adalah kunci untuk pencegahan sekunder pada pasien dengan stroke. Kepatuhan pengobatan yang buruk dapat menyebabkan keterulangan, kecacatan, atau kematian pada penderita stroke. Penelitian ini bertujuan untuk mengevaluasi tingkat kepatuhan obat pasien paska stroke dengan kejadian stroke berulang. Penelitian cross-sectional ini melibatkan 60 pasien berusia antara 30 dan 85 tahun, yang semuanya sedang menjalani perawatan stroke rawat jalan di sebuah rumah sakit di Indonesia. Kejadian stroke berulang didefinisikan sebagai mengalami stroke sekunder dalam waktu 30 hari setelah kejadian stroke awal. Dari total partisipan, 12 individu telah mengalami stroke berulang setelah episode awal mereka, sementara 48 pasien tidak mengalami stroke berulang hingga saat pengumpulan data. Data kepatuhan obat dievaluasi dengan menggunakan kuesioner MMAS-8(Morisky  Medication  Adherence  Scale). Hasil penelitian menunjukkan bahwa pada kelompok pasien paska stroke tingkat kepatuhan pasien tinggi 41,7% dan pada kelompok stroke berulang tingkat kepatuhan pasien sedang 41,7%
Studi Aktivitas Antioksidan Dari Ekstrak Etanol Daun Benalu (Dendrophthoe pentandra (L.) Miq) Pada Tanaman Pala
Authors: Besin Cecilia S. M. , Kanter Jabes W. , Maarisit Wilmar , Tumbel Silvana L. , Pareta Douglas N. , Montolalu Friska M.
Published: August 2024

Antioksidan merupakan zat yang menghambat atau mencegah kerusakan sel akibat oksidasi dari radikal bebas. Salah satu tanaman yang berkhasiat sebagai alternatif pengobatan tradisional dan berpotensi sebagai antioksidan adalah benalu pala. Penelitian ini bertujuan untuk mengetahui apakah benalu pala memiliki aktivitas antioksidan dengan melakukan uji skrining fitokimia dan Spektrofotometer UV-Vis. Metode penelitian ini menggunakan benalu pada tanaman pala dan diekstraksi dengan etanol 95% dengan metode maserasi kemudian dipekatkan dengan rotary evaporator pada suhu 40°C untuk mencegah dekomposisi senyawa yang terdapat didalamnya. Setelah itu, dilakukan uji skrining fitokimia yang bertujuan untuk mengetahui kandungan senyawa metabolit yang ada pada sampel. Pengujian aktivitas antioksidan dilakukan secara kualitatif dengan menggunakan metode DPPH pada panjang gelombang 517 nm dan pembanding vitamin C menggunakan Spektrofotometer UV-Vis, sedangkan uji skrining fitokimia secara kuantitatif dengan uji tabung reaksi untuk mengetahui senyawa-senyawa metabot yang ada seperti alkaloid, flavonoid, saponin, taniin, triterpenoid, dan steroid. Berdasarkan hasil penelitian yang dilakukan pada uji skrining fitokimia, menunjukkan bahwa sampel memiliki senyawa metabolit seperti alkaloid, flavonoid, saponin, tanin, dan triterpenoid. Sedangkan untuk hasil uji antioksidan nilai IC50 yang diperoleh dari hasil persamaan regresi linier ialah 4,644 untuk ekstrak kasar dan nilai IC50 vitamin C sebagai pembanding 0,169. Berdasarkan hasil uji analisis yang dilakukan, dapat disimpulkan bahwa  daya antioksidan yang didapatkan tergolong sangat kuat dan berpotensi menangkal radikal bebas DPPH.
Uji Aktivitas Antidiabetes Ekstrak Daun Epazote (Dysphania ambrosioides L.) Pada Tikus Putih (Rattus novergicus) Yang Diinduksi Aloksan
Authors: Tapehe Christian J. A. , Pareta Douglas N. , Tulandi Selvana S. , Potalangi Nerni O.
Published: August 2024

Diabetes mellitus merupakan penyakit gangguan metabolisme kronis dengan multietiologi yang sering ditandai dengan kadar gula darah yang tinggi disertai dengan adanya gangguan metabolisme karbohidrat, lipid, dan protein. Faktor resiko terjadinya diabetes mellitus antara lain genetik, obesitas, serta usia dengan penyakit yang memerlukan pengelolaan untuk mencegah komplikasi. Daun Epazote Dysphania ambrosioides L.adalah jenis tumbuhan herbal yang memiliki kandungan tanin, alkaloid, saponin, steroid yang memiliki kemampuan untuk memperbaiki dan meregenerasi sel ? pankreas serta menghambat peningkatan kadar gula darah. Penelitian yang digunakan adalah eksperimental laboratorium dengan Metode Rancangan Acak Lengkap (RAL) yang terdiri dari tiga perlakuan, masing – masing terdiri dari tiga ekor hewan uji sebagai ulangan.Perlakuan A ekstrak daun Epazote dengan dosis 75 mg/kgBB, Perlakuan B ekstrak daun Epazote 150 mg/kgBB, Perlakuan C Kontrol Negatif. Hasil penelitian menunjukkan bahwa pemberian ekstrak daun Epazote memiliki aktivitas untuk menurunkan kadar gula darah pada hewan percobaan. Pemberian dosis ekstrak 75 mg/kgBB memiliki rata - rata penurunan 64%, 150 mg/kgBB memiliki rata – rata penurunan 33%. Kesimpulan, daun Epazote memiliki aktivitas untuk menurunkan kadar gula darah.
Dynamical Black holes in the FLRW universe
Authors: Kazıcı Ciftci Dilek , Kalender Ozlem
Published: August 2024

Observations show that massive black holes, thought to be at the center of galaxies and galaxy clusters, are dynamical
objects and interact with their environments. Black holes are characterized by their mass and angular momentum,
and they are time-varying objects embedded in the cosmological Friedman-Lemaitre-Robertson-Walker (FLRW)
universe. Finding analytical solutions for the dynamical black holes with all these properties is very important in
theoretical physics. In the present work, we obtain Einstein’s field equations for our predicted dynamical black
hole geometry and obtain analytical solutions using the energy-momentum tensor obeying imperfect fluid dynamics.
Misner-Sharp-Hernandez mass, turnaround radius, and apparent horizon are analyzed and compared with the recent
observations.
Toxoplasmose congênita: revisão bibliográfica
Authors: Jadjischi Débora Costa , Lougon Isabela Turino , Fim Gustavo Marques , Bausen Tiffany , Souza Lais Cunha de , Xavier Vinicius Spolador , Soares Tatiane Sanches
Published: August 2024

O presente estudo em sua abordagem tem como foco quanto a toxoplasmose congênita dado ao estudo epidemiológico, onde, se refere a mesma sendo uma infecção pelo parasita Toxoplasma gondii, que não causa problemas em adultos saudáveis, mas pode causar doença grave em recém-nascidos e em pessoas com sistema imunológico enfraquecido. Problema de pesquisa: Visa-se abordar a problemática de pesquisa que elucide a questão norteadora sobre o que se configura a toxoplasmose congênita? Justificativa: O estudo se porta a descrever a toxoplasmose congênita, doença que se faz quase que exclusivamente decorrente de uma infecção materna primária durante a gestação, onde, as mulheres infectadas na fase tardia da gestação são responsáveis pelas maiores taxas de transmissão para o feto. Objetivos: Quanto ao objetivo dessa pesquisa se porta averiguar a toxoplasmose congênita que se faz estabelecido ao estudo epidemiológico. Método: metodologia que se fez utilizada compreendeu revisão bibliográfica, que se descrevem na pesquisa como ponto central demonstrar todo conhecimento sobre o tema, justificando seu processo de execução que se concluirá sobre os conteúdos aqui demonstrados e pesquisados. Discussão: Considera-se que para que seja possível atingir os objetivos propostos, foi realizada pesquisa tendo como foco adquirir conhecimentos acerca do assunto, buscando assim a explicação de um problema, analisando publicações referentes a determinado tema, onde, classifica-se que a toxoplasmose é causada por um parasita que vive e multiplica-se em gatos, a infecção pode causar morte em algumas crianças e problemas neurológicos de longo prazo em outras, portanto que a infecção no feto é mais grave se o feto for infectado no início da gravidez.
Hot pressing of SiC additivated with Al2O3 and Y2O3
Authors: Gonçalves Danilo Abílio Corrêa , Sénéchal Naiara Vieira Le , Cardoso Bruno Figueira de Abreu Ferreira , Fortini Jeremias Ismael Nunes , Oliveira Márcio Jardim de , Campos José Brant de , Monteiro Sergio Neves
Published: August 2024

This work investigated the sintering of silicon carbide (SiC) with alumina (Al2O3) and yttria (Y2O3) additives by hot pressing. Mixtures of SiC with 1% and 5% Al2O3 and Y2O3 were used, pressed at 1800 °C and 1850 °C, resulting in specimens that were characterized in terms of density, microstructure, Vickers hardness and fracture toughness. The addition of 5% oxide additives provided greater densification and better mechanical properties. The temperature of 1800 °C proved to be the most effective for sintering due to the microstructure presented. The analysis revealed a homogeneous distribution of additives and grains, concluding that the 5% additive is considerably superior for increasing the densification and mechanical strength of SiC.
Biocarvões e resíduos agroindustriais potencialmente supressores de Meloidogyne incognita no algodoeiro
Authors: Novais João Marcos Pereira , Couto Eduardo Guimarães , Ferreira Paulo Afonso , Vieira Júnior José Olívio Lopes , Martins Heiriane Sousa , Galbieri Rafael
Published: August 2024

As atividades agrícolas geram um excesso de resíduos, e estes, podem ser incorporados diretamente ao solo ou transformados em um material com maior recalcitrância e estabilidade. Entretanto, pouco se sabe sobre seu efeito no manejo de fitonematoides. Este trabalho teve como objetivo avaliar o potencial de resíduos agrícolas e seus respectivos biocarvões na supressão de Meloidogyne incognita na cultura do algodoeiro. O ensaio foi conduzido em casa de vegetação, composto por 12 tratamentos, sendo: controle negativo (C(-)); controle positivo (C(+)); controle químico com abamectina; controle biológico com Bacillus subtilis (BS) e B. amyloliquefaciens (BA); capulho de algodão (CB); dejeto suíno (SW); torta de mamona (CBC); biocarvão de capulho de algodão (CBB); biocarvão de dejeto suíno (SMB); biocarvão de torta de mamona (CBCB) e o mineral zeólita clinoptilolita (MZ), com taxa de aplicação de 2% (grama de resíduo ou biocarvão/ grama de substrato). Cada tratamento foi composto por doze repetições. Como planta hospedeira foi utilizado a cultivar de algodoeiro TMG 44 B2RF, suscetível ao M. incognita. O SW reduziu a quantidade de ovos (-53%), por grama de raiz (-86%) e resultou no menor índice de galhas (3,3) e, simultaneamente, contribuiu para o maior crescimento da parte aérea e massa radicular. O CBCB foi o melhor tratamento entre os biocarvões, com redução de 60% no número de ovos por grama de raiz. A aplicação de dejeto suíno e o biocarvão de torta de mamona podem ser utilizados como ferramentas no manejo do nematoide-das-galhas.
Las maravillas de Quelucas: La niña que teje sueños en hilos
Authors: Orosco Chávez Ana Cecilia
Published: August 2024

En la región Amazonas, provincia de Chachapoyas, en las altas montañas de la querida Jalca Grande, en el pueblo llamado Quelucas, vive una niña extraordinaria llamada Majherli Araceli Culqui Huaman, nacida el 24 de agosto de 2016. A sus siete añitos, Majherli destaca por su habilidad para tejer en el telar de cintura, un arte que aprendió de su querida madre Deisy Huaman Puerta. La pequeña niña es una alumna ejemplar de la Institución Educativa N° 18260 Quelucas, una escuela conocida por su enfoque innovador y su dedicación a preservar la cultura local. Aquí, Majherli participa con entusiasmo en el proyecto "Mi escuelita y mi cultura sin límites," un programa que integra el aprendizaje académico con la valorización de las tradiciones del pueblo. Le encanta formar parte de las actividades escolares, especialmente aquellas que involucran la creatividad y la cultura.
“Presupuestos para el efectivo ejercicio de participación, a través del consejo de participación ciudadana y control social del Ecuador”.
Authors: Toscano-Villamarín Nadya Alejandra , Guevara-Cedeño Elly Birmania , Chiriboga-Guzmán Rommel Enrique , Alfonso-Caveda Duniesky
Published: August 2024

El artículo de revisión bibliográfica analiza las diferencias y similitudes en la gestión, la calidad docente y el rendimiento estudiantil entre las escuelas públicas y privadas en Ecuador. El problema central abordado es la disparidad significativa en la calidad de la educación proporcionada por las dos clases de instituciones. El objetivo del estudio es identificar las causas de las desigualdades y proponer estrategias para mejorar la equidad y la calidad educativa en el país. La metodología empleada incluyó la comparación de múltiples revisiones bibliográficas y estudios de campo publicados entre 2019 y 2023. Se utilizaron bases de datos reconocidas como ArXiv, BioRxiv, CiteSeerX, Cogprints, Scielo, Dialnet, Scopus y Elsevier, y se aplicaron criterios estrictos de inclusión y exclusión para seleccionar estudios de alta calidad. En total, se seleccionaron 26 artículos relevantes, que fueron analizados para extraer datos pertinentes sobre gestión escolar, calidad docente y rendimiento estudiantil. Los resultados revelan que las escuelas privadas, con mayores recursos y autonomía, presentan mejores condiciones de infraestructura y recursos educativos, lo que contribuye a un mejor rendimiento académico de sus estudiantes. Los docentes en escuelas privadas tienen acceso a más oportunidades de desarrollo profesional y condiciones laborales más favorables en comparación con los docentes de escuelas públicas, los estudiantes de escuelas privadas tienden a obtener mejores resultados en pruebas estandarizadas y tienen mayores tasas de graduación y acceso a educación superior. Las conclusiones destacan la necesidad de reformas educativas que promuevan la equidad, incluyendo mejoras en la infraestructura escolar, oportunidades de desarrollo profesional continuo para los docentes y una distribución equitativa de recursos. Abordar las disparidades es crucial para garantizar una educación de calidad para todos los estudiantes en Ecuador, independientemente de su contexto socioeconómico.
Combined experimental and theoretical investigation of electronic properties of nitrides
Authors: N. Jandow N.
Published: August 2024

A comprehensive study of the electronic structure of group-III nitrides (AlN, GaN, InN, and BN) crystallizing in the wurtzite, zinc-blende, and graphitelike hexagonal (BN) structures is presented. A large set of the x-ray emission and absorption spectra was collected at the several synchrotron radiation facilities at installations offering the highest possible energy resolution. By taking advantage of the linear polarization of the synchrotron radiation and making careful crystallographic orientation of the samples, the bonds along c axis (rr) and ‘‘in plane’’ (u) in the wurtzite structure could be separately examined. Particularly for AlN we found pronounced anisotropy of the studied bonds. The experimental spectra are compared directly with ab initio calculations of the partial density of states projected on the cation and anion atomic sites. For the GaN, AlN, and InN the agreement between structures observed in the calculated density of states (DOS) and structures observed in the experimental spectra is very good. In the case of hexagonal BN we have found an important influence of insufficient core screening in the x-ray spectra that influences the DOS distribution. The ionicity of the considered nitrides is also discussed.
AVANÇOS NA PREVENÇÃO DO HIV: PROGRESSOS E DESAFIOS NA IMPLANTAÇÃO DA PROFILAXIA PRÉ-EXPOSIÇÃO
Authors: Santos Bráulio Érison França dos , Miranda João Gabriel Barbosa , Matos Neto Celso de , Oliveira José Lucas Duarte de
Published: August 2024

Introdução: A prevenção do HIV constitui um pilar fundamental no combate à epidemia global de AIDS. Recentemente, a introdução da Profilaxia Pré-Exposição (PrEP) revolucionou o cenário de prevenção do HIV, fornecendo uma ferramenta eficaz para diminuir a transmissão do vírus em populações de alto risco. Objetivo: Este artigo explora como a PrEP pode influenciar em futuras estratégias de prevenção ao HIV/AIDS, detalhando os avanços e desafios, e proporcionando uma base sólida para que profissionais de saúde, pesquisadores e formuladores de políticas desenvolvam abordagens mais eficientes no combate ao HIV/AIDS.  Material e Métodos: Este estudo é uma revisão narrativa da literatura, analisando estudos-chave que demonstram a eficácia da PrEP, incluindo regimes de dosagem diária e sob demanda, aplicados em diversos contextos e populações. A análise também incluiu diretrizes globais emitidas por organismos renomados, como a Organização Mundial da Saúde (OMS) e a UNAIDS. Resultados: A PrEP provou ser altamente eficaz na redução da transmissão do HIV entre populações de alto risco. Contudo, desafios como a resistência à medicação, a adesão ao tratamento e o estigma ainda persistem. Identificaram-se estratégias eficazes para melhorar o acesso à PrEP, especialmente em regiões de baixa e média renda. Conclusão: A educação e o envolvimento comunitário são cruciais para promover a PrEP como uma opção de prevenção viável, reduzindo a discriminação nos serviços de saúde. As direções futuras de pesquisa incluem o desenvolvimento de novas formulações, que podem facilitar a adesão e oferecer alternativas práticas para os usuários. A PrEP é reconhecida não apenas como uma ferramenta médica, mas também como um instrumento de empoderamento para comunidades em risco, contribuindo para uma abordagem mais holística e eficaz na prevenção do HIV.
NEUROCISTICERCOSE: ASPECTOS TERAPÉUTICOS
Authors: Neves Marco Antonio Orsini , Silva Cássio Eduardo dos Santos , Padilha Deirdre Barros Ferreira , Prado Katrinny Almeida da Silva , Aquino Mayra Rocha Corrêa de , Tavares Thiago de Mello
Published: August 2024

Modelo do estudo: Revisão integrativa da literatura. Objetivo: Analisar a neurocisticercose e suas formas terapêuticas. Metodologia: Os artigos foram pesquisados nas bases de dados National Library of Medicine (PubMed), Latino-Americana e do Caribe em Ciências da Saúde (LILACS) e Scientific Electronic Library Online (SciELO). Resultados: Dentre os 10 artigos analisados nesta revisão, buscou-se identificar os que tinham o tratamento da neurocisticercose como foco principal, além de artigos que consideraram fatores como definição, diagnóstico, epidemiologia e prevenção. Os resultados da revisão mostraram que o tratamento medicamentoso com albendazol e praziquantel é eficaz na redução da carga parasitária em pacientes com neurocisticercose. A maioria dos estudos incluídos relatou uma melhora nos sintomas clínicos em pacientes que receberam esses medicamentos. Apesar dos resultados favoráveis observados em vários ensaios clínicos, o uso de drogas cisticidas tem sido questionado, levando a confusão e decisões incorretas de manejo. Conclusão: Os estudos apontam que o albendazol e o praziquantel têm mecanismos de ação distintos, mas eficazes no combate à doença. Além disso, a associação da dexametasona tem mostrado benefícios no controle da resposta inflamatória e redução da hidrocefalia. No entanto, ainda há muito a ser feito em termos de desenvolvimento de novas drogas e vacinas mais eficazes, com melhores perfis de segurança e durações reduzidas de tratamento. Portanto, é necessário continuar pesquisando e investindo na área para que se possa oferecer um tratamento cada vez mais eficaz e seguro para os pacientes com neurocisticercose.
National Capital Development Policy as a Strategy for Achieving Sustainable Development Goals in Indonesia
Authors: Azizah Nur , Burhan M. Ghiffari Ramadhan , Irwansyah Irwansyah , Sagena Uni W. , Masjaya Masjaya
Published: August 2024

This study aims to evaluate the implementation of the Nusantara Capital development planning policy as a strategy to accelerate the achievement of the development of sustainable cities and communities. This study uses a normative legal research method. The collected legal material is then qualitatively analyzed to describe the problem and answer the study objectives. The results show that the development of the Nusantara Capital has been strategically integrated with the SDGs. A solid legal and policy foundation has facilitated a holistic approach in planning and implementing this project, covering everything from efficient spatial organization to sustainable resource management. This policy implementation demonstrates a solid commitment to sustainable development principles, including environmentally friendly infrastructure development, social integration, and community participation. Moreover, the development of the Nusantara Capital explicitly supports the achievement of the development of cities and communities, which aims to create inclusive, safe, resilient, and sustainable urban environments. This approach ensures that development targets such as adequate housing, sustainable transportation, cultural heritage preservation, and environmental management are holistically integrated, meeting long-term objectives while addressing urbanization challenges. Therefore, it is recommended that the government should continue to strengthen policies and regulations that support sustainable development practices, ensuring transparency and accountability in every phase of development. For the private sector and industry, it is highly advisable to invest in environmentally friendly technologies and sustainable practices that support the vision of the Nusantara Capital as a model for future cities. Meanwhile, the community should be actively involved in the planning and decision-making processes to ensure that development is inclusive and meets local needs. Cooperation among all parties is essential to achieve inclusive, safe, resilient, and sustainable development goals, in line with SDG 11.
Perfetti method: a sustainable approach to cognitive and functional enhancement in intellectual disabilities
Authors: Sailema Sailema Tannia Gioconda , Cárdenas Medina Jorge Humberto , Fernández Soto Gerardo Fernando , Cashabamba Padilla Franklin Hernán
Published: August 2024

Background: As for the functional and cognitive capacities of people with intellectual disabilities, there has been evidence of a deficit in activities of daily living such as eating, getting dressed, going to the bathroom, moving around, walking, going up and down steps. And as for the cognitive area, functions such as visuospatial, attention, memory, concentration and language were evaluated. A correct treatment has not been given to these areas so they cannot develop a better quality of life. Objective: To apply the Perfetti Method for functional and cognitive abilities improvement in patients with intellectual disabilities. Methods: The research is an observational study with a quantitative approach and with 20 participants. An initial assessment was made and after 12 weeks of intervention with the Perfetti Method a final assessment was carried out. Sociodemographic characteristics, Barthel index assessment scales and the Montreal Cognitive Assessment (MoCA)-Test were used. Results: After 12 weeks of applying the Perfetti Method Guide, it significantly improved functional and cognitive abilities and consequently the participants´ quality of life. The application of the T student test, for related samples, established a relation between the Barthel Index and the Montreal Cognitive Assessment (MoCA)-test, with a significance of (p<0.001); Conclusions: The Application of the Perfetti Method is effective to improve the functional and cognitive capacities of people with intellectual disabilities and their quality of life.
Fornecimento distribuído de água: Uma analogia didática
Authors: Alves Zedequias Machado , De Oliveira Lilian
Published: August 2024

The scarcity of natural resources is a recurring problem in modern daily life. Much has been done to find solutions that generate the least environmental and social impact. Among the various challenges to face the scarcity of resources, this work presents in a playful way the issues involving the scarcity of water resources in a given region and the solutions found by the society of its surroundings. The work addresses the importance of the solutions presented to meet the needs of all. The format of the problem and the solutions presented is based on the text "The fable of the roast pigs". The issue of water scarcity is addressed, and any similarity with the scarcity of energy resources and the use of Distributed Generation (DG) is mere coincidence, or not.
Behaviour of grouted connections of monopile structures at ultimate static and cyclic limit states
Authors: Lotsberg Ivar , Serednicki Andrzej , Cramer Erik , Bertnes Håvard
Published: August 2024

In recent years, reports of offshore wind turbine topside structures settling on their monopile foundation structure have emerged, with the resulting force flow in the structures found to be different from that intended at the design stage. As a result, a joint industry project was carried out by Det Norske Veritas (DNV) between late 2009 and early 2011, to investigate the structural capacity of these connections. It was found that the axial capacity of the grouted connections is more sensitive to the diameter (capacity reducing more than predicted at larger diameters) and surface tolerances than had been accounted for in the existing design standards. This paper reviews the past and present industry practice relating to the design of grouted connections in monopile structures. The physical behaviour of the connections is explained and some of the most critical issues related to the design of large diameter grouted connections are assessed. Based on the experience with the settlements of cylindrical shaped grouted connections, a design procedure with conical shaped connections was developed. The recommended design methodology has been supported by a number of laboratory tests. The main findings from that joint industry project are presented in this paper.
ARTIFICIAL INTELLIGENCE BASED SUSTAINABLE COTTON CROP PRODUCTION USING REMOTE SENSING DATASET
Authors: Salman Qadri  , Ayesha Hakim  , Asiya Khan  , Abdul Razaq  , Muhammad Saifullah  , Abdul Hanan  , Qaim Hassan  , Syed Ali Nawaz  , Aamir Hussain
Published: August 2024

The decline in cotton production in Pakistan has directly impacted the country's foreign exchange earnings, plummeting from twelve million bales in 1991, the number decreased to four million bales in 2020. Considering a substantial portion of Pakistan's exports are linked to the textiles area, with 40% of jobs tied to production, this decline is concerning. Factors such as climate change and changes in biotic and abiotic stresses have contributed to substantial losses in cotton production. In Pakistan, where 90% of farmers face resource constraints, there is a pressing need for more accurate mechanisms to understand the challenges in crop production. Timely acknowledgment and adoption of more flexible approaches to irrigation, fertilizer application, and pest and disease control are crucial. Excessive use of pesticides has exacerbated the situation, leading to the development of resistance among pests and diseases. Traditional visual inspection methods alone are insufficient for predicting crop health effectively, resulting in deprived crop yields and financial losses for agrarians. Enhancing crop health condition requires leveraging information gathered from remote sensing and terrestrial sensors, along with truth field surveys. By processing this data through tools like the Decision Support System for Agrotechnology Transfer (DSSAT) and employing machine learning techniques such as artificial neural networks, more accurate local and field-level advice can be provided to farmers. This approach aims to optimize crop management practices, reduce losses, and ultimately improve farmers' incomes.
UNLOCKING INCLUSIVE COMPETITIVE VALUE CHAINS OF CHICKPEAS IN PUNJAB, PAKISTAN: A WALKING THE CHAIN APPROACH TO IDENTIFY BARRIERS, OPPORTUNITIES, AND OPTIONS
Authors: Burhan Ahmad  , Mubashir Mehdi  , Rajendra Adhikari  , Muhammad Haseeb Raza  , Muhammad Amjed Iqbal  , Elizabeth Petersen
Published: August 2024

Improved and inclusive agricultural value chains by linking all stakeholders’ particularly farmers with the market have remained a challenge in Pakistan. This study is aimed at identifying issues and obstacles that hinder the development of chickpeas’ value chain by using the lens of value sought by consumers. Primary data are collected from consumers, retailers, wholesalers, processors, and farmers to understand consumer value and identify opportunities and options to create and deliver greater consumer value along the chickpea chain. Results of focus group discussion of consumers depict that the important quality parameters are cleanliness, grading, and packaging. Moreover, results of the data analysis of farmers and other stakeholders reveal that mostly households stick to their traditional farm management practices and crop types. Value addition and storage of chickpeas at the farm level is very limited. Farmers are weakly connected with the market indicating the high potential of developing and upgrading chickpeas value chains in Pakistan. Value addition at the stakeholders’ level, such as processors and wholesalers existed but not purely consumer oriented. However, value addition at retailers’ level is consumer oriented. It indicates that information flow from consumers to value chain actors is not adequate. An important option can be to give small cleaning and grading machine to farmers and building their capacity to perform value added activities and adopt appropriate storage techniques at farm level which facilitate them to sell value added products at good price to processors, wholesalers or retailers which could lead to increase the farmers’ profitability and in turn motivate them to increase area under chickpea production.
Mind Unveiled: Cutting-Edge Neuroscience and Precision Brain Mapping
Authors: Singh Ajit Pal , Saxena Rahul , Saxena Suyash , Maurya Neelesh Kumar
Published: August 2024

Neuroscience, a dynamic field at the forefront of scientific exploration, is unravelling the complexities of the human brain. By merging biology, psychology, physics, and computer science, researchers are gaining profound insights into cognition, behaviour, and the neurological underpinnings of diseases. Brain mapping is a key component of recent advancements. Techniques like fMRI, PET, and DTI offer unprecedented views of brain structure and function. The Human Connectome Project and similar initiatives have produced detailed maps of brain connections, revealing how different regions interact to support cognition and behaviour. These maps are crucial for identifying disease biomarkers, predicting treatment responses, and developing targeted therapies. Molecular biology and genetics are also driving progress. Researchers are uncovering the genetic basis of neurological disorders, providing clues about disease susceptibility and progression. Molecular imaging techniques visualise neurotransmitter systems and cellular processes, shedding light on disease mechanisms. The integration of neuroscience with computer modelling and AI is revolutionising research. AI algorithms analyse vast datasets, simulate neural networks, and even decode neural signals for brain-machine interfaces. This has the potential for personalised medicine and ground-breaking treatments. The future holds immense promise. Techniques like optogenetics and single-cell imaging will offer even greater precision in studying brain circuits. However, we must address ethical considerations around data privacy, cognitive enhancement, and brain-altering interventions. Neuroscience is not just about understanding the brain; it's about improving lives. Researchers are striving to conquer neurological disorders and maximize human potential by pushing the boundaries of knowledge and technology while upholding ethical principles.
A Systematic Study on Mirror Repeats in CTLA4 and KCNJ11 Genes of Diabetes
Authors: Yadav Aarti , Sarawag Ritu , Yadav Sandeep
Published: August 2024

All cellular functions are controlled by the regulatory material which is constituted majorly by variety type of repeat elements. Among that types a unique pattern of bases form a Mirror repeat (MR) which thought to plays variety of roles at the genomic level that include regulation of gene expression, genomic integrity, triplex structure formation etc. The present research focused on identification of Mirror repeats in different genes types involved in both diabetes types. Two different genes CTLA4 (T1D) & KCNJ11 (T2D) were targeted to identify these sequence type. A manual method refers as FPCB is utilized to extract out MR sequences. The targeted gene sequences were divided into short regions so that it can be handled out easily while bioinformatics based analysis. Among the both types it was reported that both genes have different pattern of distribution of MR sequences. CTLA4 have 346 MR sequences in total in which MR235 have highest length of 50bps. In case of KCNJ11 a total no of 235 MR sequences were reported in which MR105 having highest length of 58bps. The present study will be helpful to elucidate the roles of MR sequences in diseases development & progression. It will be helpful for sequence based protein finding studies using bioinformatics tools as well as wet lab experiments.
A Comprehensive Review on PARP Inhibitors in Targeted Therapy for Cancers
Authors: Guduri Mounika , Kolluru Samyuktha , Pasupulati Haritha , Padi Satyanarayana SV
Published: August 2024

The poly (ADP-ribose) polymerase (PARP) family of enzymes involves and regulates various cellular processes and essential functions, such as apoptosis, transcription process, and DNA repair. PARPs (PARP-1, PARP-2, PARP-3) are a branch of familiar proteins that play a crucial role in repairing DNA damage in a human gene involved in different cancers and regulate the base excision repair (BER) pathway. As a target-based drug therapy for cancer, inhibition of PARP stops the PARP-1 and -2 from repairing damaged and mutated DNA in cancer cells, and eventually, the cancer cells die. Considering the limited available therapies for the treatment of advanced and recurrent cancers, PARP inhibitors (PARPi) are the first approved cancer drugs that particularly target the response to DNA damage in BRCA (BReast CAncer gene)-1/2 mutated ovarian, pancreatic, prostate, and breast cancers. Recently, six PARPi viz., olaparib, rucaparib, niraparib, talazoparib, fuzuloparib, and pamiparib were approved as monotherapy or in combination with other classes of anticancer agents for the maintenance treatment of advanced or recurrent cancers. Moreover, PARPi appears to improve progression-free survival in women with recurrent platinum-sensitive ovarian cancer as an adjuvant to the conventional treatment. Importantly, the use of PARPi in the management of germline BRCA1/2-associated cancers is a novel therapeutic strategy, representing the first successful targeted therapy in improving outcomes in patients with hereditary cancers. Although resistance to these agents has been reported recently, however, various therapeutic strategies have been employed to overcome resistance and improve the sensitivity of PARPi in the treatment of ovarian, breast, gastric, pancreatic, and prostate cancers.
Anthelmintic Screening of Hylocereus polyrhizus Rind Extracts
Authors: Yesudanam Sinchu , A. S. Aparna Raj , J. Jothika , Sreelakshmi R. S. , Sunil Soniya M.
Published: August 2024

The purpose of this study was to evaluate the rind extract of Hylocereus polyrhizus's anthelmintic efficacy. Ethanol and water were utilized to extract the powdered rind of H. polyrhizus. The phytochemical screening of H. polyrhizus ethanol extract (HPEE) and water extract (HPAE) was done. The adult motility assay and resistance-modifying study were then used to screen for the plant's anthelmintic properties against Eudrilus eugeniae. Due to its morphological and physiological resemblance to the human intestinal roundworm, Eudrilus eugeniae was chosen in the investigation. On E. eugeniae, HPEE and HPAE demonstrated dose-dependent paralytic and fatal effects. The anthelminthic activity of albendazole was also assessed by HPEE and HPAE through resistance-modifying research and the adult worm (E. eugeniae) motility assay. The addition of different concentrations of HPEE and HPAE considerably (p < 0.05) increased the activity of albendazole against E. eugeniae. Against E. eugeniae, they exhibited dose-dependent anthelmintic action. When compared to HPEE, HPAE exhibits the strongest activity. Albendazole's lethality and paralytic action were considerably increased by HPEE and HPAE. HPEE and HPAE underwent phytochemical screening, which identified the presence of coumarins, alkaloids, glycosides,   tannins, and saponins. The findings of this investigation demonstrate the anthelmintic activity of     H. polyrhizus.
Molecular Diagnosis of Hymenolepis nana Parasite in House Rats and Children in Babylon Province, Iraq
Authors: Al-Talla Dyaa H.A. , Al-Bermany Safaa M.K.
Published: August 2024

Background: Hymenolepiasis in humans is typically caused by the dwarf tapeworm Hymenolepis nana, or occasionally by the rodent tapeworm Hymenolepis diminuta. The current study aimed to detect and Hymenolepis nana infecting Children and House rate using molecular techniques.
Methods: Seventy five samples of Children and seventy five of House rats were examined from December 2023 to March 2024 by the molecular techniques.
Results: The results showed that the overall percentage of Hymenolepis nana infection was 13.3 (10 out of 75) in (Children) (female 31 and male 44) and in House rats was 16% (12 out of 75). These results also found that the infected males recorded the highest infection rate compared with infected females, where the percentages were (Children) male 10.9% (7/44) and female 9.7% (3/31), and (House rats) respectively. In addition, 75 stool samples of humans (children) in different areas (Al- Qasim, Al- Musayyib, Al- Hilla, Al- Kifl, Al- Hamza Al- Gharbi, and Al- Shomali) and study the effects of sex and areas with ages in humans. The infection rates of Hymenolepis parasite in humans by using molecular, the study revealed in humans on the infection rates by molecular. In humans H. nana was showed an infection rate 13.3% (10/75), the high infection rate was 20% (2/10) in Al Musayyib and 12.5% (1/8) in Al Kifl and it was 5.9% (1/17) in Al- Qasime with no significant difference, 20% (2/10) in Al- Hamza Al Gharbi, and 10% (1/10) in Al Shomali.
Conclusion: The results were showed the parasite H. nana of the infected humans in this study tack three gropes (1-5) years about 20% (5/25), (6-10) years, 9.4% (3/32) and (11-15) years 11.1% (2/18).
W czasach pandemii i wojny. Bezpieczeństwo dostaw gazu ziemnego do odbiorców w Rumunii i Bułgarii (styczeń 2020 – sierpień 2023)
Authors: Skrzyński Tomasz
Published: August 2024

Do kwietnia 2022 roku zdecydowanie największym zewnętrznym dostawcą gazu ziemnego do Bułgarii i Rumunii była Rosja. Dla Bułgarii gaz rosyjski miał znaczenie podstawowe. W Rumunii uzupełniał własne wydobycie. Porównano, w jakim stopniu pandemia, kryzys energetyczny i konflikt zbrojny wpłynęły na dostępność gazu dla odbiorców bułgarskich i rumuńskich. W 2020 roku w tych krajach bezpieczeństwo dostaw gazu do odbiorców pogorszył m.in. wzrost jego konsumpcji, dalszy spadek wydobycia (w Bułgarii i Rumunii) i tranzytu przez te kraje. Rozbudowa infrastruktury po kwietniu 2022 roku była w dużej mierze przyspieszeniem realizacji działań zaplanowanych przed 2020 rokiem. Bułgaria skupiła się na dywersyfikacji dostaw za pośrednictwem Grecji i Turcji. Rumunia m.in. kontynuowała starania o zbudowanie infrastruktury umożliwiającej wykorzystanie gazu ze złóż pod dnem Morza Czarnego.
Cultural Adaptation as the Basis of a Civilizational System
Authors:   Yerevan State University, Hovhannisyan David , Gevorgyan Anna ,   Yerevan State University
Published: August 2024

The article discusses the concepts of "civilization" and "culture" and addresses several fundamental questions related to them. It attempts to analyze the transformation in the understanding of the concept of "freedom" amidst the changes in civilizational systems and the development of cultural systems. Civilization is interpreted as a unity of rules and institutions, while culture is seen as the freedom constrained by these rules and institutions. The article also touches on the necessity for Armenians to adapt to the emerging new civilizational system and proposes the idea of a "network state" as the best solution for this adaptation.
Observing Ocean Boundary Currents: Lessons Learned from Six Regions with Mature Observational and Modeling Systems
Authors:   Laboratoire d'Etudes en Géophysique et Océanographie Spatiales (LEGOS), French National Centre for Scientific Research, Ayoub Nadia , Chidichimo María , Dever Edward , Guo Xinyu , Krug Marjolaine , Míguez Belén , Morris Tamaryn , Sprintall Janet , Tanaka Kiyoshi , Todd Robert , Wilkin John , Álvarez-Fanjul Enrique , Andres Magdalena , Bosse Anthony , Edwards Christopher , Gula Jonathan , Kerry Colette , Roughan Moninya , Miyazawa Yasumasa , Oddo Paolo , Oka Eitarou , Zaba Katherine , Kim Sung Yong
Published: August 2024

Ocean boundary currents are complex and highly variable systems that play key roles in connecting the open and coastal ocean through cross-slope circulation and upwelling of nutrient-rich water. The structure, strength, and variability of boundary currents are associated with a broad range of spatial and temporal scales. For that reason, long-term boundary current monitoring is challenging and requires the use of complementary observing platforms and sensors coupled with numerical simulations. The Ocean Observations Physics and Climate Panel Boundary Systems Task Team recently held a virtual dialogue series to discuss six mature boundary current monitoring systems. The goal of the series was to examine strategies for developing a conceptual design for sustained observing activities applicable to a wide range of boundary current systems. This article provides a brief overview of the six systems, including users and the observational and modeling components needed to achieve scientific, operational, and societal goals. Ocean observing best practices and recommendations are shared to provide guidance for the coordination and sustainability of observing systems at ocean boundaries and to strengthen and integrate partnerships across and within the global observing networks.
Actitudes hacia la sexualidad en el adulto mayor y la salud mental
Authors: Velasco Rodríguez Víctor Manuel , Limones Aguilar María de Lourdes , Suárez Alemán Gabriel Gerardo , Moreno Castruita Lizbeth Yaremi , Palomares Mejía Ana Karen , Sánchez Gómez Lesly Marlene , Orozco Hernández Ivanna Nazareth
Published: August 2024

La sexualidad es una parte esencial de la vida de los seres humanos, pero tiende a menospreciarse en los adultos mayores, lo que conduce al desarrollo de creencias y prejuicios negativos hacia ella, sin embargo, se ha mencionado que es una dimensión que influye importantemente en la salud física y mental, por lo que se efectúa este estudio para determinar la asociación existente entre las creencias sobre sexualidad y la salud mental en adultos mayores. Se efectuó un estudio transversal de entrevista en 100 adultos mayores seleccionados mediante un muestro no probabilístico por conveniencia. Previa explicación y firma consentimiento informado se aplicaron cuestionario CASV y el instrumento Yesavage. Se analizan asociaciones entre ambas mediciones mediante X2 y regresión lineal en el paquete estadístico SPSS V21. Se encuentra asociación de actitudes negativas hacia la sexualidad y puntuaciones del instrumento de Yesavage mayores a 5 puntos, principalmente en las dimensiones de prejuicios y mitos, así como las actitudes positivas se asocian a puntuaciones menores. La actitud positiva hacia la sexualidad en esta etapa de la vida puede estar asociada con un mejor bienestar psicológico. Sin embargo, son necesarios más estudios para explorar en profundidad esta relación
Pemanfaatan Sumber Daya Alam Pesisir Pantai Selatan Sebagai Penunjang Pembangunan Pariwisata Pantai Gemah
Authors: Dwi Astuti Wahyu Nurhayati  , Novi Tri Oktavia
Published: August 2024

Penulisan karya ini bertujuan untuk menjelaskan Pemanfaatan Sumber Daya Alam Laut dan Pesisir Sebagai Pendukung Pengembangan Objek Wisata di Pantai Selatan (Pantai Gemah) Kabupaten Tulungagung. Latar belakang dalam penulisan karya ini adalah karena Indonesia merupakan negara yang memiliki kekayaan keanekaragaman sumber daya alam yang melimpah. Kekayaan sumber daya alam yang melimpah yang dimiliki oleh negara Indonesia dapat dimanfaatkan sebagai upaya untuk melaksanakan pembangunan ekonomi dalam rangka meningkatkan kesejahteraan masyarakat. Salah satu bentuk realisasi pemerintah dalam melaksanakan pembangunan ekonomi adalah dengan membuat Jalur Lintas Selatan (JLS) yang berada di pesisir pantai selatan Kabupaten Tulungagung. Pembangunan Jalur Lintas Selatan (JLS) di pesisir pantai selatan Kabupaten Tulungagung memberikan dampak positif bagi perekonomian masyarakat di sekitar pesisir pantai selatan, salah satunya adalah kemudahan akses menuju Pantai Gemah. Adanya Jalur Lintas Selatan (JLS) memudahkan akses menuju Pantai Gemah sehingga banyak wisatawan yang datang ke Pantai Gemah. Dengan banyaknya wisatawan yang datang ke Pantai Gemah, masyarakat sekitar memanfaatkan keadaan tersebut dengan melakukan kegiatan ekonomi seperti berjualan di kawasan Pantai Gemah.
Pengelolaan Objek Wisata Danau Timbang Bunga Pengantin Oleh Bumdes Aur Kuning Di Kabupaten Kuantan Singingi
Authors: Sonia Anggraini  , Mimin Sundari Nasution
Published: August 2024

Pengelolaan objek wisata merupakan bentuk dalam memanfaatkan potensi alam yang ada di suatu daerah yang menjadi sumber pendapatan daerah. Pengelolaan adalah proses yang membantu merumuskan kebijaksanaan dan tujuan memberikan pengawasan pada semua hal yang terlibat dalam pelaksanaan dan pencapaian tujuan. Kata management sendiri sudah diserap kedalam bahasa Indonesia menjadi kata manajemen yang berarti sama dengan “pengelolaan”, yakni sebagai suatu proses mengoordinasi dan mengintergrasi kegiatan kegiatan kerja agar dapat diselesaikan secara efisien dan efektif. Objek wisata danau timbang bunga pengantin merupakan objek wisata yang terletak di Kabupaten Kuantan Singingi. Tujuan pengelolaan ini untuk mengetahui bagaimana pengelolaan objek wisata danau timbang bunga pengantin oleh BUMDes Aur Kuning di Kabupaten Kuantan Singingi. Metode penelitian ini menggunakan metode penelitian kualitatif dengan teknik pengumpulan data menggunakan data primer dan data sekunder yang diperoleh dari hasil observasi, wawancara, dan dokumentasi yang dianalisa peneliti dalam mendapatkan data. Penelitian ini menggunakan teori dari George R.Terry tentang fungsi pengelolaan yaitu perencanaan, pengorganisasian, pelaksanaan,dan pengawasan. Hasil penelitian menunjukkan bahwa pengelolaan objek wisata danau timbang bunga pengantin oleh BUMDes Aur Kuning masih belum optimal, dikarenakan masih terdapat beberapa perencanaan pengelolaan yang yang belum terealisasi dan perlu adanya perbaikan dalam pengelolaan objek wisata danau timbang bunga pengantin.
Guest Satisfaction to Stay in The Four-Star Rating Hotel in Padang: The Influence Of Hospitableness and Guest Engagement
Authors: Arifandi Ilham  , Wanda Melisa Nurlita  , Wira Tri Annisa  , Feri Ferdian
Published: August 2024

The purpose of this research is to find out how the hospitableness and guest engagement that exists between employees and guests have an impact on guest satisfaction. This type of research is a quantitative descriptive research with a causal associative method. The population in this study were all guests who had stayed at a four-star hotel in the city of Padang. The sampling technique is non-probability sampling using purposive sampling. The number of samples in this study amounted to 97 responses. Data collection techniques were carried out using a questionnaire with a Likert scale that had been tested for validity and reliability. The data analysis used in this research is descriptive analysis with the help of SPSS version 20.00. From the results of the research that has been done, the Friendliness and Guest Involvement variables have a positive and significant effect on guest satisfaction at four-star hotels in the city of Padang. It can be said that based on this research, guest satisfaction can occur if the hotel can provide hospitableness and guest engagement good relations with guests during their stay, then guests will feel satisfied.