bluuebunny/crossref_metadata_2025 huggingface dataset:
Aspect-Based Sentiment Analysis using Machine Learning and Deep Learning Approaches
Authors: Kumar Dinesh , Gupta Avdhesh , Gupta Vishan Kumar , Gupta Ashotosh
Published: July 2023

Sentiment analysis (SA) is also known as opinion mining, it is the process of gathering and analyzing people's opinions about a particular service, good, or company on websites like Twitter, Facebook, Instagram, LinkedIn, and blogs, among other places. This article covers a thorough analysis of SA and its levels. This manuscript's main focus is on aspect-based SA, which helps manufacturing organizations make better decisions by examining consumers' viewpoints and opinions of their products. The many approaches and methods used in aspect-based sentiment analysis are covered in this review study (ABSA). The features associated with the aspects were manually drawn out in traditional methods, which made it a time-consuming and error-prone operation. Nevertheless, these restrictions may be overcome as artificial intelligence develops. Therefore, to increase the effectiveness of ABSA, researchers are increasingly using AI-based machine learning (ML) and deep learning (DL) techniques. Additionally, certain recently released ABSA approaches based on ML and DL are examined, contrasted, and based on this research, gaps in both methodologies are discovered. At the conclusion of this study, the difficulties that current ABSA models encounter are also emphasized, along with suggestions that can be made to improve the efficacy and precision of ABSA systems.
Malarial Diagnosis with Deep Learning and Image Processing Approaches
Authors: Dath Mogalraj Kushal , Nazir Nahida , Dhankhar Amita , Solanki Kamna , Dahiya Omdev
Published: July 2023

Malaria is a mosquito-borne disease that has killed an estimated a half-a-million people worldwide since 2000. It may be time consuming and costly to conduct thorough laboratory testing for malaria, and it also requires the skills of trained laboratory personnel. Additionally, human analysis might make mistakes. Integrating denoising and image segmentation techniques with Generative Adversarial Network (GAN) as a data augmentation technique can enhance the performance of diagnosis. Various deep learning models, such as CNN, ResNet50, and VGG19, for recognising the Plasmodium parasite in thick blood smear images have been used. The experimental results indicate that the VGG19 model performed best by achieving 98.46% compared to other approaches. This study demonstrates the potential of artificial intelligence to improve the speed and precision of pathogen detection which is more effective than manual analysis.
Relationship between impulsivity, aggression and blood ghrelin, vitamin D, lipids levels in borderline personality disorder
Authors: BAYKARA Sema , KARAKAŞ Şahin , KAYA Şuheda , TAŞCI Gülay , TELO Selda
Published: July 2023

Purpose: This study aimed to investigate the correlations between impulsivity and aggression, and blood ghrelin, lipids, and vitamin D levels in Borderline Personality Disorder (BPD).

Materials and Methods: Thirty female patients with BPD and 30 healthy controls were included to the study. Sociodemographic Data Form, Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), Barratt Impulsivity Scale Short Form (BIS-11-SF), Buss-Perry Aggression Questionnaire (BPAQ) were applied.

Results: Ghrelin, cholesterol, and triglyceride (TG) levels were higher in BPD patients (p=0.013, p=0.042, p=0.019, respectively); however, there was no significant difference between the groups based on vitamin D, High-density lipoprotein (HDL) and Low-density lipoprotein (LDL) levels. There was no correlation between ghrelin, and lipid and vitamin D levels. The BIS-11 and BPAQ scores were higher in BPD group. A positive correlation was determined between ghrelin and BIS-11 scores. A positive correlation was found between vitamin D and ‘anger’ subscale score of BPAQ. A negative correlation was identified between triglyceride and the ‘verbal aggression’ subscale score of BPAQ.

Conclusion: BPD is a disorder with several hospital admissions, frequent comorbid conditions, problematic social relationships, and functionality, and the treatment is quite difficult. Regulation of Ghrelin, vitamin D and lipid levels could assist clinicians in the treatment and clinical follow-up of the disease.
Model Component Analysis of Online Storytelling Media via Gamification to Enhance the Digital Literacy Skills of Students in Computer Education Thailand
Authors:   Faculty of Science and Technology, Nakhon Pathom Rajabhat University, Thailand, Aumgri Charinthorn , Apirating Kaiyasith
Published: July 2023

At present, digital literacy skills (DLS) are essential for student teachers for developing the ability to use creative IT which is useful for effective work implementation. However, student teachers do not really possess DLS and are unable to apply them to their teaching methods, so the digital storytelling media via gamification to enhance DLS: DSML(Digital story model learning) is needed as an instrument to support them in acquiring digital literacy. The objectives of this research were to analyze the factors of the DSML and to assess the model appropriateness. The study was implemented through 42 papers of relevant articles and research from specific primary and secondary sources. The research instruments included lesson plans, the learning model, assessments of DLS, and assessments of workpieces. The findings of the study show that the factors of model consist of activities through DSML in 2 aspects with 10 factors and 29 variables. The test was validated by experts for the appropriateness of the learning through DSML. Overall, the DSML was found to have the highest appropriateness level (mean = 4.62, S.D. = 0.13) so it can be used in real learning and teaching situations and it is helpful for enhancing students’ DLS in the design and development of digital media. Based on the findings, the students could extend their learning scope with DLS in building digital media. These skills are necessary for Thai teachers in the future, and the model can be a prototype for doing classroom-based research or presenting research work at a national level.
Design and Implementation of Gamified Learning System for Mutation Testing
Authors:   the Department of Information Engineering and Computer Science, Feng Chia University, Taiwan, Hsueh Nien-Lin , Xuan Zeng Hung , Daramsenge Bilegjargal
Published: July 2023

Mutation Testing is used to test case improvement mechanism for evaluating the effectiveness of test cases by generating a large number of mutants. In the past, some approaches are proposed to improve the performance of generating the mutants. In recent years, many studies have begun to explore the software engineering education of mutation testing, trying to make students understand its concept through gamification. In this paper, we apply gamification theory and build a gamified learning system for mutation testing, named code immunity boost (CIB), taking the story of vaccine development as a sense of mission. We invited students to learn mutation testing through the relationship between leukocyte (test case), vaccine (mutant) and human body (program). Students can play the role of a vaccine and stimulate the testing of test cases by writing mutants to improve the quality of the program. We adopted the benchmark programs commonly used in mutation testing research, and developed a code vaccine incubator (CVI) tool to generate a large number of mutants as the experimental cornerstone of this study. Final experiments show that our tool can help mutation testing education, as the performance and quality of the experimental group is better than that of the control group. The response from the questionnaire also shows students like learning by our gamified tool. We therefore recommend to promote such software testing education approach by integrating our tool with popular online programming tools such as Online Judge system.
Forensic Dentistry - The Role of the Dentist in Human Identification
Authors: Vlasiadis Konstantinos , Koutsamani Maria
Published: July 2023

A dentist's role often involves screening, diagnosing, preventing, and treating a variety of oral diseases. However, it is equally important in both the medical and the judicial field through the identification of unidentified deceased individuals. For this reason, the science of Forensic Dentistry has been developed, the contribution of which is valuable, especially in cases of criminal acts or mass disasters, where the number of victims is high. Its work is characterized as demanding, in which case the immediate and effective action of specially trained and experienced professionals is necessary. The methods of identification used work with outline   the collection, careful examination, radiographic and photographic imaging and recording of post-mortem evidence of teeth and their impressions on the skin alongside the jaws, the lips and the palatal rugae of mucosa in order to be compared with existing ante-mortem and to draw conclusions regarding the racial and age identification of the deceased as well as finding other useful information about him/her. The forensic dentist's contribution to the administration of justice is essential through keeping detailed records of patients and excellent cooperation with local authorities towards a valid and reliable identification process.
Francisco del Castillo, el apóstol de Lima
Authors: Nieto Vélez Armando
Published: July 2023

El autor intenta en este libro acercarnos a la época, al ambiente y a la real personalidad de Francisco del Castillo (1615 ? 1673), a quien Juan Pablo II en sus dos visitas al Perú no dudó en proclamar como modelo de existencia sacerdotal.
Religión y evangelización en Vilcabamba (1572-1602)
Authors: Regalado de Hurtado Liliana
Published: July 2023

A lo largo del siglo XVI Vilcabamba estuvo presente en las discusiones y acontecimientos del mundo colonial para después, a partir de 1602, aproximadamente, incorporarse a la memoria común, a veces con tintes legendarios. En varias oportunidades la Iglesia Católica realizó esfuerzos para procurar la evangelización de las poblaciones lugareñas y de la propia élite de los incas. Sus acciones, junto con las promovidas por las autoridades y el desenvolvimiento particular de los colonizadores hacen del espacio vilcabambino y sus anexos un objeto importante para el estudio histórico desde una perspectiva amplia que permita el análisis global de esa realidad, sin restar valor a temas tan importantes como los de la Religión y Evangelización en Vilcabamba, materia de este libro.
Los mineros de la Cerro de Pasco 1900-1930
Authors: Flores Galindo Alberto
Published: July 2023

Los mineros de la Cerro de Pasco, 1900-1930 fue originalmente una tesis presentada en 1972 a la Pontificia Universidad Católica del Perú, y tuvo el propósito de desarrollar los estudios sobre movimientos socials contemporáneos en el Perú. El autor incide en el desencuentro que se produce en 1930 entre un naciente proletariado minero y un recién fundado Partido Comunista del Perú. Posteriormente, este mismo problema fue retomado por Flores Galindo tanto en un libro de conjunto sobre la época titulado Apogeo y crisis de la República Aristocrática (Lima, 1979), como sus trabajos sobre Mariátegui, especialmente en el ensayo La agonía de Mariátegui (Lima, 1982, 2a. ed.)
Trilce, estructura de un nuevo lenguaje
Authors: Vegas García Irene
Published: July 2023

César Vallejo (1892-1938) fue un poeta surrealista peruano "avant la lettre". Deconstruyó el idioma español y el lenguaje poético de una manera que ningún otro poeta de habla hispana lo ha hecho. Este libro es un estudio lingüístico, estilístico y hermenéutico de la estructura del lenguaje poético de Vallejo en su libro de vanguardia Trilce (1922). Se explora sus 77 poemas verso por verso, y frase por frase, aplicando la teoría y el método de Structure du Langage Poétique de Jean Cohen (1966). Buscando las desviaciones fonéticas, sintácticas y semánticas del lenguaje común que hizo Vallejo, se hizo posible comprender sus transgresiones. Luego, se analiza los poemas reconstruyendo cada desviación, a través de una interpretación hermenéutica y estilística.
Tecnologia para treinamento físico durante a pandemia COVID-19
Authors: Amaro Alexandre Slowetzky , Teixeira Paula Fernandes
Published: July 2023

Objetivo: O objetivo do presente estudo foi descrever o uso de aplicativos de smartphone para treinamento físico (APP) e a participação em Treinos Mediados por Tecnologia (TMT) em uma amostra de estudantes-atletas (EA) universitários durante a pandemia COVID-19. Método: Nossa pesquisa descritiva transversal avaliou EA de uma Universidade privada do estado de São Paulo usando um questionário adaptado à plataforma Google Forms. Resultado: Participaram da pesquisa 271 EA (Homem=158; Mulher=113; Midade=21,74±2,26 anos); sendo que 163 (60,1%) utilizaram APP, 214 (79%) utilizaram TMT e 247 (91,1%) utilizaram ambos os recursos. Foram citados 46 diferentes APP, sendo os principais: 1. Nike Training Club (n=75, 37,7%); 2. Nike Run Club (n=29; 14,6%); 3. Adidas Running (n=13; 6,5%) e 4. Leap Fitness Group (n=13; 6,5%). O Teste χ2 revelou que as mulheres foram as principais usuárias de tecnologia [APP (p=0,005; V=0,169); TMT (p<0,0001; V=0,216) e; APP+TMT (p=0,009; V=0,158)] durante a pandemia. Os EA amadores utilizaram mais APP (p=0,003; V=0,209) do que EA federados e ex-federados. Considerações finais: Os resultados destacam o extensivo uso de tecnologia na manutenção dos treinamentos físicos dos EA universitários durante a pandemia COVID-19, principalmente entre as mulheres e EA amadores. Estudos futuros devem quantificar os efeitos do uso de tecnologia na saúde física e emocional dos EA universitários.
Práticas corporais na estratégia saúde da família
Authors: Andrade Sabrina Raquel de Lima , Aguiar Milena de Oliveira , Silva Andre Luis Façanha da
Published: July 2023

Introdução: As políticas públicas sobre as práticas corporais e atividade física (PCAF) tem ganhado notoriedade a nível internacional. No Brasil, o Sistema Único de Saúde, incorpora a PCAF na agenda política, apresentando a relevância na produção do cuidado e promoção da saúde. Objetivo: Analisar as percepções sobre as práticas corporais dos profissionais de Educação Física e usuários de grupo de práticas corporais da Estratégia Saúde da Família de Sobral/CE. Metodologia: A pesquisa qualitativa é desenvolvida a partir da avaliação de quarta geração, tipo responsivo, através da interação das entrevistas e negociação consensos e dissensos. Foram entrevistados nove profissionais de Educação Física e cinco integrantes do grupo Corpo e ação. Nessa pesquisa, o método foi adaptado para construção em sete passos: contrato com o campo, organização da avaliação, identificação dos grupos de interesse, desenvolvimento de construções conjuntas, ampliação das construções conjuntas, preparação da agenda de negociação e execução da negociação. Resultados e discussão: A percepção dos usuários é de acolhimento e longitudinalidade através das PCAF, tendo caráter de cuidado, relacional e terapêutico. Os profissionais apresentam a compreensão de saúde ampliada, diversidade das práticas e atuação interprofissional, as quais muitas são reforçadas pelo estudo continuado, principalmente, na residência. Considerações finais: As práticas corporais nesse espaço tornam assegurador de vínculos por proporcionar o espaço grupal como garantia do elo para o cuidado integral e ampliado. Além de transpassar as visões hegemônicas do corpo biológico e epidemiológico e suprir visões dualistas, apesar das dificuldades pontuadas.
BULANIK-GÖSTERGEBİLİM IŞIĞINDA YÂD-I MÂZİ’DE BİÇEM VE ANLAM
Authors: TURAN Taner
Published: July 2023

Yâd-ı Mâzi, küçük hassasiyetlerin öncelendiği Ara Nesil şiirinde dikkati çeker. Bunun nedeni eserin anlatım ve içerik düzleminde Abdülhak Hâmid ve Recaizâde Mahmud Ekrem çizgisini takip etmesidir. Bu savı kanıtlamak adına Yâd-ı Mâzi’den hareketle biçem ve anlamın nasıl oluşturulduğu belirli yöntemlerle incelenebilir. İlk olarak anlatımın biçimini kavramsallaştırmak için biçembilimin kavramları kullanılabilir. Ancak biçembilimciler çoğunlukla anlatımın biçimine odaklanmış ve anlatısallık düzeyinde incelemeler yaparak anlamı belirli yönlerden geri planda bırakmışlardır. Çağdaş biçembilim ise biçembilim ve göstergebilimin verilerinden yararlanarak gösterge-biçembilim kavramıyla biçem ve anlamı birlikte incelemeye çalışmıştır. Bu noktada metnin yüzeyindeki anlamsal yoğunluğu belirlemek ve incelemek için biçemsel ve anlamsal olanaklar dikkate alınabilir ve bulanık mantığın verileri gösterge-biçembilimin kavramsal alanına dâhil edilebilir. Çünkü klasik mantığın aksine bulanık mantık 0 ve 1 arasındaki sürekliliği esas alır ve yazınsal metin bu sürekliliğe koşut olarak anlamı ve biçemi oluşturur. Biçem ve anlamın metni oluşturması, kavramların birtakım yönlerden kesişmesini sağlar. Bu kesişim, metnin farklı düzeylerde çözümlenmesini gerektirir. Biçem ve anlamın kendi içerisinde bir oluşu ifade etmesi biçemsel ve anlamsal tercihlerin birbirlerine olan üyelik derecesini arttırır. Bu durum bulanık mantığın gösterge-biçembilimin kavramsal alanına dâhil edilmesiyle incelenebilir. Bu çalışmada gösterge-biçembilim, bulanık mantığın verileriyle desteklenmiş ve metin çözümleme düzeyleri oluşturularak Yâd-ı Mâzi’de biçem ve anlamın oluşumu araştırılmıştır.

Anahtar kelimeler: Gösterge-biçembilim, dilbilim, bulanık-göstergebilim, Menemenlizâde Mehmed Tahir.
AŞK MESNEVİLERİNDEKİ KADIN KAHRAMANLARA VERİLEN NASİHATLER
Authors: EREN KAYA Fazile
Published: July 2023

Divan edebiyatında birbirine âşık iki kahramanın âşık olma serüvenleri, karşılaştıkları zorluklar, kavuşmak için verdikleri mücadeleler gibi uzun soluklu hikâyeler mesnevi nazım şekliyle yazılır. Bu mesnevilerde asıl konu aşk olsa da şair çeşitli konulardaki düşüncelerini ve dünya görüşünü okuyucuya aktarmak için eserinde kendisine alan açar. Şairin kendine ait düşünceleri çoğu zaman mesnevilerin giriş ve sonuç bölümlerinde bulunur. Bu bölümlerin yanı sıra asıl konunun anlatıldığı bölümde de kimi vesilelerle şairler kendi seslerini duyururlar. Anlatılan aşk hikâyesindeki kahramanların nezdinde iyi bir hükümdarın özelliklerinin ve iyi bir vezirin sahip olması gereken yeteneklerin yanı sıra kadınların ailelerine ve çocuklarına karşı sorumlulukları gibi konularda fikirlerini belirterek okuyucuyu yönlendirmeye çalışırlar. Bunu kimi zaman hikâyesini anlatmaya başladığı kahramanın özelliklerinden bahsederek kimi zaman da kahramanda olması gereken bir özelliği ona nasihat ederek yaparlar.

16. yüzyıl şairlerinden Fuzûlî’nin Leylâ vü Mecnûn, Taşlıcalı Yahyâ’nın Yûsuf u Zelîhâ, Celîlî’nin Hüsrev ü Şîrîn, Lamiî’nin Vâmık u Azrâ ve Hamîdî’nin Hurşîd ü Hâver isimli mesnevilerinde kadın kahramanlar âşık oldukları, sevgiliden ayrı düştükleri ya da evlendikleri zamanlarda yine hikâye kahramanı olan bir büyükten nasihat alırlar. Bu nasihatler hem eseri yazan şairin hem de eserin yazıldığı dönemin kadına bakışını yansıtması bakımından dikkat çekicidir.

Bu çalışmada şairlerin adı geçen mesnevilerinin kadın kahramanları Leylâ, Zelîhâ, Şîrin, Azrâ ve Hurşîd’den aşka düşen ya da evlenmeye hazırlanan genç bir kadın olarak hangi konularda nasıl davranmasını bekledikleri üzerinde durulacaktır.
YÛNUS EMRE DÎVÂNINDA SUR UR- YAPISI ÜZERİNE
Authors: BAYRAKTAR ERTEN Nesrin
Published: July 2023

Yûnus Emre, hümanizm felsefesinin tartışılmaz önderlerinden biri olarak Türk dili, Türk tarihi ve Türk edebiyatında önemli bir yere sahiptir. Şiirlerinin hem içerik olarak hem de sanatsal olarak değeri çok sevilmesine yol açmıştır. Bu nedenle eserlerinin pek çok nüshası bulunmaktadır.

Bu çalışmada Yunus Emre Dîvânı’nda geçen ve dört büyük melekten biri olan İsrâfil’in Kıyamet Günü’nde üfleyeceği boru olan Sûr ile birlikte kullanılan yapı üzerinde durulacaktır. Ele alınacak olan ür- eyleminin geçtiği şiirler, hemen her nüshada farklı yerde olduğundan şiirlerin ilk dizesi ile ele alınacaktır.

Ür- eylemi, Dîvân’da 3 yerde -IcAk zarf-fiil ekiyle birlikte kullanılmıştır. Eylemin -A ekiyle kullanımları, okuma açısından belirleyici olmamakla birlikte, -IcAk ekiyle kullanımı; ür- mi ur- mı biçiminde olduğunu belirleyici olmasına karşın çoğu araştırmacı tarafından Sûr ur- biçiminde okunmuştur. Bunun nedeni bazı nüshalarda -IcAk zarf-fiil ekinin sonundaki ك harfinin birkaç yerde müstensih hatasıyla ق olarak yazılmasıyla da ilişkilidir.

Bu çalışmada eylemin ür- biçiminde okunması ve değerlendirilmesi gerektiği, delilleriyle açıklanmaktadır.
Inflammasome as an early pathophysiological phenomenon of inflammation in skin diseases and other pathologies
Authors: Klimov V. V. , Zagreshenko D. S. , Urazova O. I. , Klimov A. V. , Naidina O. A. , Tsyplina E. Yu. , Kologrivova E. N. , Koshovkina T. V. , Koshkarova N. S.
Published: July 2023

The review considers the molecular structure of inflammasomes, routes of inflammasome activation, appropriate downstream effects, and their association with autoinflammatory, autoimmune, neurodegenerative, and allergic diseases and malignancies with a focus on the involvement of the skin in these pathologies. Inflammasome activation is interpreted as an early pathophysiological event before the onset of inflammation, and, especially, if inflammasome dysregulation occurs. All research aspects related to the NLRP3 inflammasome are described in detail. The review also considers promising directions for therapeutic interventions in NLRP3-associated diseases.
Factors affecting the development of liver fibrosis in patients who experienced COVID-19
Authors: Kruchinina M. V. , Pershina N. E. , Svetlova I. O. , Kruchinina E. V.
Published: July 2023

The aim of the review is to highlight the main factors affecting the development of liver fibrosis and possible mechanisms of liver damage in patients who have experienced COVID-19. A search was carried out using keywords in the Scopus, Web of Science, and PubMed databases in literary sources of the last three years on factors associated with fibrogenesis in novel coronavirus infection.

The review presents the main mechanisms of liver damage in COVID-19: direct effects on hepatocytes and cholangiocytes, hypoxia, and immune-mediated and drug-induced damage. We analyzed the significance of factors affecting fibrosis development in patients with COVID-19: chronic diffuse liver diseases, against which COVID-19 occurs, such as non-alcoholic fatty liver disease, alcohol-associated liver disease, chronic hepatitis B, C, and cirrhosis of the liver.

Damage to the liver in coronavirus infection develops by several mechanisms. The development of COVID-19 against the background of diffuse liver pathology of various genesis is associated with progression of these diseases (increased fibrogenesis) and a poorer prognosis.
A clinical case of migrainous stroke
Authors: Plotnikov D. M. , Alifirova V. M. , Mosienko E. S.
Published: July 2023

Migrainous stroke is a rare combination of frequently occurring diseases; only a few cases have been described in the domestic literature. The complexity of differential diagnosis is due to the fact that at the stage of initial manifestations, these two conditions can mimic each other. Treatment strategy and further prevention for each of these diseases is different, so timely and convincing early diagnosis is crucial. The presented clinical case describes a case of ischemic stroke in a young woman who had been suffering from migraine for a long time, which did not fully meet the criteria for migrainous infarction. The patient was treated at the regional vascular center of the Tomsk Regional Clinical Hospital, there was a positive trend in the neurological status. The catamnesis of the disease was tracked. It was suggested that endothelial dysfunction is the main pathogenetic factor in the formation of an ischemic focus against the background of a protracted migraine attack.
Gypsogenin Fighting for A Position in The Pentacyclic Triter-penes Game of Thrones on Anti-Cancer Therapy: A Critical Review
Authors: Radwan Mohamed , Abd-Alla Howaida I. , Elmezayen Hatem , Abourehab Mohammed A.S. , El‐Beeh Mohamed E. , Tateishi Hiroshi , Otsuka Masami , Fujita Mikako
Published: July 2023

Abstract: In the last decade, gypsogenin has widely grabbed the attention of medicinal chemists by virtue of its prominent anti-cancer potential. Despite its late identification, gypsogenin proved itself as a new an-ti-proliferative player battling for a front position among other classic pentacyclic triterpenes such as oleanolic acid, glycyrrhetinic acid, ursolic acid, betulinic acid, and celastrol. Herein, we present insights into the anti-cancer activity of gypsogenin and its semisynthetic derivatives and go further by introducing our perspective to judiciously guide the prospect rational design. The present article opens a new venue for better exploitation of gypsogenin chemical entity as a lead compound in cancer chemotherapy. To the best of our knowledge, this is the first review article exploring the anti-cancer activity of gypsogenin derivatives.
Wettability Alterations of Sui Main Limestone Carbonate Rocks Using Methylene Blue and Alumina Based Nanofluids: Implications for EOR
Authors: Shar Abdul Majeed , Qureshi Muhammad Furqan , Bhutto Darya Khan , Memon Faisal Hussain
Published: July 2023

The wettability of the oil-brine-rock systems is very challenging mainly for the carbonate reservoirs and it plays a significant role to enhance the oil recovery (EOR). Carbonate rocks are mad-up of complex lithology, hence these requires careful treatments in controlling their wetting behavior for enhanced oil recovery. Therefore, it is extremely important to modify their wettability from an oil-wet rock behavior to a water-wet so that the residual oil can be produced efficiently. Thus, the present study has examined the effectiveness of alumina nanofluid as well as a new chemical methyl blue to alter the wettability. The methyl blue is released on massive scale from various industries i.e. pharma, textile and food industry which is a key environmental concern which contaminates the water table. Hence the study, explores the effects of MB and alumina nanofluid on the wettability. The effect of nanofluids formulated via dispersing the alumina nanoparticles in aqueous solutions at various concentration (0. 0.05, 0.3, 0.50, 0.75 and 1.0 wt. %) were tested for wettability modification under different physio-thermal conditions. Subsequently, the wettability change was examined for the samples treated with different concentrations of MB (10, 15, 30, 50 and 100 mg/L) for 7-days at two different temperatures of (25 and 50 0C). The results showed that hydrophobicity of the SML carbonate rock has significantly reversed while treating with alumina nanofluids and MB. Thus, the wettability modification/reversal via treatment of MB and alumina nanofluid can be an effective mechanism to hydrogen injection and for EOR processes.
Strategic Synergies between 5G and Beyond and Smart Grids
Authors: Martinelli Marina , Mazoni Alysson Fernandes , Consoni Flávia Luciane , Furtado André Tosi
Published: July 2023

This article provides a comprehensive review of the intersection of 5G technology and Beyond, and Smart Grids, focusing on the potential of Vehicle-to-Fog as an industrial alternative for addressing energy efficiency challenges in data processing. This study aims to investigate relevant articles and patents to understand the collaborative potential between 5G and Smart Grids. It explores how to establish new regulatory standards within the architectural framework of 5G to facilitate decentralized data processing and remodel energy consumption patterns. The hypothesis suggests that decentralized 5G architecture and Smart Grids can be most effectively applied through vehicular fogging powered by solar energy. A combined quantitative and qualitative methodology guides the exploration of articles and patents. The study concludes by advocating for new standards that embrace decentralized 5G data processing, emphasizing the potential of Vehicle-to-Fog and the future deployment of 6G technology in Smart Grids. These advancements can significantly enhance energy efficiency in the context of 5G and pave the way for future innovations.
Do More With Less? Lobectomy vs Segmentectomy for Patients With Congenital Pulmonary Malformations
Authors: MD Beatrice Trabalza Marinucci , MD Cecilia Menna , MD Paolo Scanagatta , MD Silvia Fiorelli , MD Matteo Tiracorrendo , MD Giuseppe Naldi , MD Alessandro Inserra , MD Francesco Macchini , MD Erino Angelo Rendina , MD Mohsen Ibrahim
Published: July 2023

Background: Congenital Pulmonary Malformations (CPMs) are rare benign lesions potentially causing infective complications and/or malignant transformation requiring surgery even when asymptomatic. CPMs are infrequent in adult but potentially detected at any age. There is not a consensus indicating the correct extent of resection in both adults and paediatrics. This retrospective multicentric study aims to identify the appropriate surgical resection to prevent the recurrence of related respiratory symptoms. Methods: Between 2010 and 2020, a total of 96 patients (adult and pediatric) underwent surgery for CPMs in 4 centers. A 2:1 propensity score matching (considering sex and lesion side) was performed, identifying 2 groups: 50 patients underwent lobectomy (group A) and 25 sub-lobar resections (group B). Clinical and histopathological characteristics, early and late complications and symptom’s recurrence were retrospectively analyzed and compared between the two groups by univariate and multivariate analyses. Results: Patients who underwent lobectomy had a statistically significant lower rate of recurrence (4% vs 24% of group B, p = 0.014) and a lower rate of intraoperative complications (p = 0.014). Logistic regression identified sub-lobar resection (p=0.040), intra- and post-operative complications (p=0.105 and 0.022) and associated developed neoplasm (p=0.062) as possible risk factors for symptoms recurrence after surgery. Conclusions: Pulmonary lobectomy seems to be the most effective surgical treatment for CPMs, guaranteeing stable remission of symptoms and a lower rate of intra- and postoperative complications. To our knowledge this is one of the largest studies comparing lobectomy and sub-lobar resections in patients affected by CPMs, considering the low incidence worldwide.
Preferential Tissue Sites of Different Cancer-risk Groups of Human Papillomaviruses
Authors: Okodo Mitsuaki , Okayama Kaori , Sasagawa Toshiyuki , Teruya Koji , Settsu Rei , Mizuno Shuichi , Ishii Yasuyoshi , Oda Mizue
Published: July 2023

The oncogenic potential of human papillomavirus (HPV) may be used to determine the tissue tropism of each HPV type. Cervical cancer develops in the squamo-columar junction of the cervices, and most such lesions are induced by high-risk (HR) HPV types. This suggests that HR types preferentially infect the cervix, whereas the preferential infection site for low-risk (LR) types is not well defined. Determination of HPV tropism when using cytology samples can be uncertain since it is difficult to avoid contamination of cell samples between the cervix and the vagina. Herein, cell samples were carefully collected by independently scraping the cervix and vagina, after which the HPV types were determined. HPV tissue tropism was determined by considering what HPV types were positive at only one of the sites (the cervix or the vagina) as the viruses that preferentially infected that site. This method revealed that all LR types were only identified in vaginal samples, whereas 87% of HR types were identified in cervical sites. Thus, LR types may preferentially infect the vagina, whereas HR types infect the cervix. These findings suggest that preferential tissue tropism of certain HPV types is a probable factor for malignant progression.
Probiotics in Cancer Treatment: From the Laboratory to Clinical Practice
Authors: Patil Abhinandan
Published: July 2023

Probiotics are now being looked at as a possible addition to cancer treatments in both study and clinical settings. This study tries to give an overview of probiotic research as it relates to cancer, with a focus on how it might help avoid cancer, treat it, and improve the health of cancer patients. We look at developmental studies that use cell culture and animal models to look at how well probiotics work in cancer. We focus on how probiotics change the immune system, inflammation, and gut bacteria. The results of clinical studies that looked at probiotics as an add-on therapy for cancer patients are looked at to see how they affected the treatment success, side effects, and quality of life of the patients. We look at the possible benefits of probiotics for certain types of cancer, such as colorectal cancer, breast cancer, and stomach tumors. We also find the best probiotic strains for each type of cancer. We also look at the synergistic benefits of combining probiotics with standard cancer treatments like chemotherapy, radiation therapy, and immunotherapy to improve the effectiveness of treatment and lower side effects. Lastly, we talk about the present problems and future directions of probiotic research for cancer. We focus on personalized methods, ideal doses and treatment plans, finding signs of treatment success, and making probiotic-based therapies. By learning more about how probiotics could be used to treat cancer, we can create personalized, successful, and well-tolerated probiotic treatments to improve cancer outcomes.
GIS-Facilitated Germination of Stored Seeds from Five Wild-Growing Populations of Campanula pelviformis Lam. and Fertilization Effects on Growth, Nutrients, Phenol Content and Antioxidant Potential
Authors: Anestis Ioannis , Pipinis Elias , Kostas Stefanos , Papaioannou Evgenia , Karapatzak Eleftherios , Dariotis Eleftherios , Tsoulpha Parthena , Koundourakis Emmanouil , Chatzileontari Eleni , Tsoktouridis Georgios , Hatzilazarou Stefanos , Krigas Nikos
Published: July 2023

While human activities and climate change are threatening available natural ecosystems, targeted studies on the biological cycle, propagation, and cultivation of threatened species are crucial both for their conservation and sustainable exploitation. This study was designed to bridge extant research gaps regarding the vulnerable local endemic Campanula pelviformis, a wild edible green traditionally consumed in Crete (Greece) with agro-alimentary and medicinal interest as well as ornamental value. New knowledge was obtained on the abiotic environmental conditions prevailing in its wild habitats (natural distribution mapped in Geographical Information Systems and linked with open-source databases). We collected seeds from wild-growing populations (three lowland, two semi-mountainous), we tested their germination at four different temperatures (10, 15, 20 and 25oC) and under different light conditions (light/dark and darkness), and we performed fertilization trails [integrated nutrient management (INF), chemical fertilization (ChF), control] examining morphological and physiological characteristics, above- and below-ground macro- and micronutrients contents, as well as their phenol content and antioxidant capacity. There were population and temperature effects on seed germination and their interaction was statistically significant. Campanula pelviformis germinated better at 10 and 15 oC (>85% for all populations) with no preference on light conditions (98.75% and 95% in light and dark conditions). The INF application increased root dry mass, chlorophyll content index and chlorophyll fluorescence compared to other treatments and was beneficial for macro- and micronutrients concentrations in above-ground parts compared to previously studied wild-growing material, while below-ground parts were positively impacted by both fertilization types. Total phenols and antioxidant capacity were both increased by ChF fertilization. The data furnished herein led to the re-evaluation and upgrade of the feasibility and the readiness timescale for its sustainable exploitation in different economic sectors.
Multi-scale Friction Simulation of Carbon Nanotube-Reinforced Nitrile Butadiene Rubber Composites Based on Molecular Dynamics and Finite Element Analysis
Authors: Liang Ce , Shuai Changgeng , Yang Xue
Published: July 2023

Nitrile butadiene rubber (NBR) and its various composites are extensively studied as matrix materials for oil-free lubricated mechanical friction surfaces. While numerous macroscopic friction experiments can compare the frictional performance of different NBR composites, the complex material preparation and low experimental efficiency pose challenges. Nanoscale molecular dynamics (MD) simulations can help develop materials with improved friction properties, but they cannot directly provide the friction coefficients of actual macroscopic friction surfaces. Therefore, it is important to integrate the advantages of macroscopic and nanoscale friction studies and perform a synergistic analysis to modify the friction properties of composite materials. In this study, a multi-scale approach is proposed to simulate the frictional characteristics of carbon nanotube (CNT)-reinforced NBR by combining the MD friction simulation， micromechanical bridging model, and macroscopic finite element analysis (FEA) methods. The results of the multi-scale friction simulation of copper (Cu)-CNT/NBR composites show that the addition of CNTs significantly improves the frictional properties of NBR, and the extent of the improvement is related to the mass fraction of CNTs. As the mass fraction of CNTs increases (0%, 1.25%, 2.5%, 5%), the coefficient of friction decreases from 0.50 to 0.38. The results are validated by ring-block friction experiments at the same scale as the simulations.
Reproducible Quantification of the Microstructure of Complex Quenched and Quenched and Tempered Steels using Modern Methods of Machine Learning
Authors: Bachmann Björn-Ivo , Müller Martin , Britz Dominik , Staudt Thorsten , Mücklich Frank
Published: July 2023

Current conventional methods of evaluating microstructures are characterized by a high degree of subjectivity and a lack of reproducibility. Modern machine learning (ML) approaches have already shown great potential in overcoming these challenges. Once trained with representative data in combination with an objective ground truth, the ML model is able to perform a task properly in a reproducible and automated manner. However, in highly complex use cases, it is often not possible to create a definite ground truth. This study addresses this problem using the underlying showcase of microstructures of highly complex quenched and quenched and tempered (Q/QT) steels. A patch-wise classification approach combined with a sliding window technique provides a solution for segmenting entire microphotographs where pixel-wise segmentation is not applicable due to the problem of reproducibly creating unambiguous training masks. Using correlative microscopy, consisting of light optical microscope (LOM) and scanning electron microscope (SEM) micrographs as well as corresponding data from electron backscatter diffraction (EBSD), a training dataset of reference states that covers a wide range of microstructures was acquired in order to train accurate and robust ML models. Despite the enormous complexity associated with the steels treated here, classification accuracies of 88.8% in the case of LOM images and 93.7% for high-resolution SEM images were achieved. These high accuracies are close to super-human performance, especially in consideration of the reproducibility of the automated ML approaches compared to conventional methods based on subjective evaluations through experts.
MPP8 Governs the Activity of the LIF/STAT3 Pathway and Plays a Crucial Role in the Differentiation of Mouse Embryonic Stem Cells
Authors: Zhang Heyao , Yang Tenghui , Wu Hao , Yi Wen , Dai Chunhong , Chen Xi , Zhang Wensheng , Ye Ying
Published: July 2023

Mouse embryonic stem cells (mESCs) possess remarkable characteristics of unlimited self-renewal and pluripotency, which render them highly valuable for both fundamental research and clinical applications. A comprehensive understanding of the molecular mechanisms underlying mESC function is of utmost importance. The Human Silence Hub (HUSH) complex, comprising FAM208A, MPP8, and periphilin, constitutes an epigenetic silencing complex involved in suppressing retroviruses and transposons during early embryonic development. However, its precise role in regulating mESC pluripotency and differentiation remains elusive. In this study, we generated homogenous miniIAA7 tagged Mpp8 mouse ES cell lines. Upon induction of MPP8 protein degradation, we observed impaired proliferation and reduced colony formation ability of mESCs. Furthermore, this study unveils the involvement of MPP8 in regulating the activity of the LIF/STAT3 signaling pathway and Nanog expression in mESCs. Finally, we provide compelling evidence that degradation of the MPP8 protein impairs the differentiation of mESC.
ChatGPT and the Generation of Digitally Born “Knowledge”: How Does a Generative AI Language Model Interpret Cultural Heritage Values?
Authors: Spennemann Dirk H.R.
Published: July 2023

The public release of ChatGPT, a generative artificial intelligence language model, caused wide-spread public interest in its abilities but also concern about the implications of the application on academia, depending on whether it was deemed benevolent (e.g., supporting analysis and simplification of tasks) or malevolent (e.g., assignment writing and academic misconduct). While ChatGPT has been shown to provide answers of sufficient quality to pass some university exams, its capacity to write essays that require an exploration of value concepts is unknown. This paper presents the results of a study where ChatGPT 4 (release May 2023) was tasked with writing a 1500-word essay to discuss the nature of values used in the assessment of cultural heritage significance. Based on an analysis of 36 iterations, ChatGPT writes essays of limited length of about 50% of the stipulated word count which are primarily descriptive without any depth or complexity. The concepts, which are often flawed and suffer from inverted logic, are presented in an arbitrary sequence with limited coherence and without any defined line of argument. Given that it is a generative language model, ChatGPT often splits concepts and uses one or more words to develop tangential arguments. While ChatGPT provides references as tasked, many are fictitious, albeit with plausible authors and titles. At present ChatGPT has the ability to critique its own work but seems unable to incorporate that critique in a meaningful way to improve a previous draft. Setting aside conceptual flaws such as inverted logic, several of the essays could possibly pass as a junior school assignment, but fall far short of what would be expected in senior school, let alone at a college and university level.
The geo-distribution and spatial characteristics of tulou dwellings in Chaozhou, Guangdong, China
Authors: Chen Dan , Su Jia-ying , Ye Jian-ping
Published: July 2023

Tulou dwellings in Southeast China have captivated global interest due to their distinctive appearance, sustainable construction materials and technologies, and their defensive and collective housing functions. Despite several recognized as World Cultural Heritage sites, the vast majority of tulou buildings are undergoing irreversible decline and destruction, necessitating a comprehensive and systematic study. Taking 83 Tulou buildings in Raoping County, Chaozhou City, Guangdong Province as the research object, this study reconstructs the historical scenes and systematically reveals the emergence, popularity, and consolidation process of tulou dwellings as integrated defensive and residential buildings for ordinary people by conducting a comprehensive analysis of historical documents and local chronicles. Based on an extensive field investigation, the study systematically analyzes the geospatial distribution and the spatial characteristics of Raoping tulou and its residential unit. The results demonstrate the adaptability and flexibility of tulou dwellings, showcasing their developmental process and revealing the inclusive nature of these traditional residences, as well as the initiative of those who reside within them. The research findings contribute to a more dynamic, comprehensive, and authentic understanding of tulou and Chinese traditional residences, providing valuable references for the preservation and sustainable development of tulou architectural heritage.
Book Review: “The Power of Geography” – Understanding the Inﬂuence of Geopolitical Dynamics and Territoriality
Authors: Ahn Young-Jin , Juraev Zuhriddin
Published: July 2023

This book review addresses the contribution of Tim Marshall’s “The Power of Geography”. The purpose of this essay is to highlight the significant role of geography in shaping political landscapes, alliances, and global affairs through the book review. What is new about this essay is its accessible presentation of complex geopolitical concepts, making it a valuable resource for students of geography and readers interested in global politics. Through the analysis of case studies and historical background, the book illuminates the interplay between physical landscapes, territoriality, and power dynamics. The findings highlight the continuing influence of geography on nations, regional identities, and the evolving global order.
Isoamyl (E)-3-(3,4-dimethoxyphenyl)acrylate
Authors: Pamela Egar , Atmaja Lukman , Santoso Mardi
Published: July 2023

Isoamyl (E)-3-(3,4-dimethoxyphenyl)acrylate (1) was obtained 95% yield by 2-methyl-6-nitrobenzoic anhydride (MNBA)/4-dimethylaminopyridine (DMAP)-catalyzed reaction at room temperature for 190 minutes in dichloromethane. The structure of isoamyl (E)-3-(3,4-dimethoxyphenyl)acrylate (1) was established by NMR, FTIR, and the high resolution of mass spectroscopies. In vitro sun protection factor evaluation exhibited value of 37.10 ± 0.03 which indicates that isoamyl (E)-3-(3,4-dimethoxyphenyl)acrylate (1) as a sunscreen agent with high protection.
Virological and Clinical Outcomes in Adults Treated with Ribavirin Aerosol for COVID-19 Pneumonia
Authors: Messina Emanuela , Morsica Giulia , Bagaglio Sabrina , Galli Laura , Lolatto Riccardo , Sampaolo Michela , Barakat Maxime , Israel Robert J , Castagna Antonella , Clementi Nicola
Published: July 2023

The emergence of new SARSCoV-2 variants can affect vaccine efficacy, laboratory diagnosis and therapies already available, triggering interest in the search for antiviral agents for SARSCoV-2 infections. Ribavirin (RBV) is a broad-spectrum antiviral with demonstrated in vitro activity against multiple viruses, including SARSCoV-2. Methods. This retrospective study evaluated the dynamic and viral clearance of SARSCoV-2 in hospitalized adult participants (PTs) with COVID-19 pneumonia who received RBV aerosol within a compassionate use study. Was also assessed the impact of RBV on the clinical outcome and the mutational profile of SARSCoV-2. Results. The median RNA values measured in nine PTs included in the study de-creased from baseline to discharge (at BL, threshold cycle (Ct)=22.4, IQR 19.84-5.07; at discharge, Ct=27.92, IQR 26.43-36.11). Seven/9 PTs experienced a clinical improvement, while two PTs deceased during hos-pitalization. In PTs with a favorable outcome the virus clearance rate at discharge was 28.6%. The cumulative clearance rate was 71.4% within day 14th from discharge.
A mutational pattern after RBV was detected in 3/5 PTs in whom was available whole genome sequencing.
Conclusions. RBV may limit SARSCOV-2 replication resulting in a favorable clinical outcome. Ribavirin may also contribute to the mutational spectrum of SARSCoV-2.