bluuebunny/crossref_metadata_2025 huggingface dataset:
ÇEKİRDEK KAPADOKYA BÖLGESİNDE ATLI DOĞA YÜRÜYÜŞÜ FAALİYETLERİNE KATILAN TURİSTİK TÜKETİCİLERİN PROFİLİNİ BELİRLEMEYE YÖNELİK BİR ÇALIŞMA
Authors: BELBER Burcu Gülsevil , ERDOĞAN Yakup
Published: September 2019

Bu araştırma, Çekirdek Kapadokya olarak adlandırılan Nevşehir’deki, atlı doğa yürüyüşü aktivitelerini gerçekleştiren işletmeleri ziyaret eden yerli ve yabancı turistlerin profilini belirlemek amacıyla gerçekleştirilmiştir. Araştırmada kullanılan anket, 21 soru ve 5’li Likert ölçekli 2 ifadeden oluşmuş, yüz yüze anket tekniğiyle uygulanmıştır. 203’ü yerli, 203’ü yabancı 406 turistle yapılan anketler, frekans dağılımları ile bağımsız örneklem t testinden faydalanılarak incelenmiştir. Araştırmanın bulgularına göre yerli ve yabancı turistler arasındaki farklılıklar incelendiğinde; yerli turistlerden işçilerin, yabancı turistlerden memurların; yerli turistlerden 2000TL’den az ve 2000-3000TL gelire sahip olanların, yabancı turistlerden 2000-4000$ gelire sahip olanların; yerli turistlerden Ankara’dan gelenlerin, yabancı turistlerden Çin’den gelenlerin yoğunlukta olduğu tespit edilmiştir. Ayrıca, yerli turistlerin daha çok aileleriyle, bağımsız olarak; yabancı turistlerin ise arkadaşlarıyla birlikte, seyahat acentesiyle-bağımsız seyahat ettikleri belirlenmiştir. Yerli turistlerin atlı doğa yürüyüşü tesislerini çoğunlukla eğlence, yabancıların ise farklı biniş tarzlarını öğrenme amacıyla ziyaret ettikleri görülmüştür. Atlı doğa yürüyüşü tesislerini, yerli turistlerin geldikten sonra öğrendiği, yabancıların ise internetten öğrendiği görülmüştür. Söz konusu çalışmanın bulgu, yorum ve önerilerine uygun şekilde hizmetlerin hazırlanıp sunulması durumunda, belirtilen turist profilini tatmin edecek bir işletme ortamı oluşturulabilecektir. Bu sayede hem işletme imajının hem de kârlılığının olumlu yönde etkileneceği düşünülmektedir.
TÜRKİYE’DE ACİL SERVİSLERİN TOPLAM FAKTÖR VERİMLİLİKLERİNİN MALMQUİST İNDEKSİ İLE ÖLÇÜLMESİ
Authors: NALDÖKEN Ümit , ÇIRAKLI Ümit
Published: September 2019

Bu çalışma, Türkiye’de acil servislerin 2013-2016 yılları arasında toplam faktör verimliliklerini ve toplam faktör verimliliklerindeki değişimi incelemek amacıyla gerçekleştirilmiştir. Bu kapsamda, Türkiye’de 81 ilde acil servislere ait girdi ve çıktı değişkenleri kullanılarak acil servislerin toplam faktör verimlilikleri Malmquist indeksi yöntemi ile hesaplanmıştır. Çalışma sonucunda, genel olarak Malmquist toplam faktör verimliliği ve bileşenlerindeki değişim açısından 2014-2015 döneminde birtakım gerilemeler olduğu diğer dönemlerde ise Türkiye’de acil servislerin etkin bir şekilde çalıştıkları sonucuna ulaşılmıştır. 2014-2015 döneminde toplam faktör verimliliğindeki azalmada ise özellikle hekim sayısı açısından girdi kontrolünde başarı sağlanamadığı değerlendirilmektedir. Acil vakalara kısa sürede erişimde özelikle ambulans ve diğer sağlık personeli sayısının önemli unsurlar olduğu, bunların sayısındaki artışla birlikte özellikle hekim sayısının artışının daha dikkatli yapılmasının etkinliği artıracağı değerlendirilmektedir.
DO THE ETHICAL DECLARATIONS OF COMPANIES CONSIST OF SIMILAR STEREOTYPICAL CONCEPTS AND TOPICS? OR ARE THEY ORIGINAL COMMITMENTS?
Authors: AYTAR Oğuzhan
Published: September 2019

The core of corporate governance is composed of values such as transparency, accountability, fairness and responsibility. The principles of corporate governance and ethical approach are built on these core values. Consequently, there is a need for guidelines on how managers and other employees should behave ethically on certain issues. In this context, the aim of the study is to identify the concepts emphasized in the ethical declarations of companies and to reveal the focus themes, differences and similarities of the sectors and companies included in the Corporate Governance Index in Turkey. Content analysis method, one of the qualitative research methods, was performed in the study. The reason for the selection of companies included in the BIST Corporate Governance Index as a sample is because of the fact that the companies within this index have certain standards in terms of corporate governance and ethical principles and they are accepted as cynosure for other companies. As a result of this research, the themes that the company and sector groups intensified were determined and significant differences have been identified among companies and sectors.
MÜŞTERİ MEMNUNİYETİ, DUYGUSAL YAKINLIK, MÜŞTERİ SADAKATİ VE AĞIZDAN AĞIZA PAZARLAMA ARASINDAKİ İLİŞKİLERİN İNCELENMESİ: PERAKENDE SEKTÖRÜ ÖRNEĞİ
Authors: EMİNLER Osman , ALTUNIŞIK Remzi , ESKİLER Ersin
Published: September 2019

Hızla değişen dünyada artan rekabet neticesinde, firmalar müşterileri ile sürdürülebilir bir ilişkiyi tesis etmenin yollarını aramaktadır. Değişen tüketici davranışları neticesinde müşteriler ile uzun süreli ilişkilerin kurulmasının daha fazla gayret gerektirdiği görülmektedir. Müşteriler ile hedeflenen bu uzun dönemli ilişkinin tesisi için işletmelerin müşteri odaklı bir bakış açısına ihtiyacı olduğu bilinmektedir. Ayrıca, müşteriler ile kurulacak bu çok yönlü ilişkiler firmaların geleceğinin şekillenmesinde son derece önemlidir. Bu çalışmada, işletmeler ile müşteriler arasında yakın ilişki kurulmasında rol oynadığı düşünülen müşteri memnuniyeti, duygusal yakınlık, müşteri sadakati ve ağızdan ağıza pazarlama kavramları arasındaki ilişkilerin incelenmesi amaçlanmaktadır. Araştırma bağlamında kasti örnekleme tekniği ile 486 perakende müşterisinden elde edilen verilerin analizinde, SPSS 20.0 paket programı kullanılmıştır. Verilerin analizinde tanımlayıcı istatistikler, Pearson doğrusal korelasyon analizi ve PROCESS prosedüründen yararlanılmıştır. Bulgular, müşteri memnuniyeti ile ağızdan ağıza pazarlama arasındaki ilişkide hem duygusal yakınlık hem de sadakat değişkeninin kısmi aracılık etkisine sahip olduğunu göstermektedir. Sonuç olarak, müşteri memnuniyeti, duygusal yakınlık, müşteri sadakati ve ağızdan ağıza pazarlama kavramlarının birbirleri ile ilişkili olduğu ve müşterilerin perakende mağaza tercihlerinin şekillenmesinde önemli ölçüde tesir ettiği ifade edilebilir.
DÖNÜŞÜMCÜ LİDERLİK VE ÖRGÜTSEL BAĞLILIK İLİŞKİSİNDE LİDERE OLAN GÜVENİN ARACI ROLÜ ÜZERİNE BİR ARAŞTIRMA
Authors: DEDE Nurten Polat
Published: September 2019

Örgütsel bağlılığın çalışan tutum ve performansını işletme amaçlarına katkı sağlayacak şekilde etkilediği bilinmektedir. Dönüşümcü liderliğin çalışan bağlılığını artırmadaki olumlu etkileri birçok araştırmacı tarafından ortaya konmuştur. Bu çalışma, dönüşümcü liderliğin, örgütsel bağlılığın alt boyutları olan devam bağlılığı, duygusal bağlılık ve normatif bağlılık üzerindeki etkisinde, lidere olan güven değişkeninin aracı rolünü tespit etmeyi amaçlamaktadır. Çalışmanın örneklemini İstanbul Dudullu Organize Sanayi Bölgesinde çalışan, 315 personel oluşturmakta olup, veriler anket yöntemi ile elde edilmiştir. Çalışmada verilerin analizi için SPSS 25.0 ve AMOS 24.0 kullanılmıştır. Yapılan analizler sonrasında, dönüşümcü liderliğin duygusal bağlılık üzerinde anlamlı bir etkisinin olmadığı ancak devam bağlılığı ve normatif bağlılığı anlamlı ve pozitif etkilediği sonucuna ulaşılmıştır. Ayrıca dönüşümcü liderlik ve devam bağlılığı ilişkisinde lidere olan güvenin aracı rolünün olduğu tespit edilmiştir. Bu sonuçlar doğrultusunda liderlerin, dönüşümcü liderlik davranışları göstererek ve çalışanlarda güven duygusu oluşturarak, çalışanların örgütteki varlığını devam ettirme isteklerini artırabilecekleri ifade edilebilir.
MEN1-associated primary hyperparathyroidism in the Spanish Registry: clinical characterictics and surgical outcomes
Authors: Lamas Cristina , Navarro Elena , Casterás Anna , Portillo Paloma , Alcázar Victoria , Calatayud María , Álvarez-Escolá Cristina , Sastre Julia , Boix Evangelina , Forga Lluis , Vicente Almudena , Oriola Josep , Mesa Jordi , Valdés Nuria
Published: September 2019

Primary hyperparathyroidism is the most frequent manifestation of multiple endocrine neoplasia type 1 (MEN1) syndrome. Bone and renal complications are common. Surgery is the treatment of choice, but the best timing for surgery is controversial and predictors of persistence and recurrence are not well known. Our study describes the clinical characteristics and the surgical outcomes, after surgery and in the long term, of the patients with MEN1 and primary hyperparathyroidism included in the Spanish Registry of Multiple Endocrine Neoplasia, Pheochromocytomas and Paragangliomas (REGMEN). Eighty-nine patients (49 men and 40 women, 34.2 ± 13 years old) were included. Sixty-four out of the 89 underwent surgery: a total parathyroidectomy was done in 13 patients, a subtotal parathyroidectomy in 34 and a less than subtotal parathyroidectomy in 15. Remission rates were higher after a total or a subtotal parathyroidectomy than after a less than subtotal (3/4 and 20/22 vs 7/12, P < 0.05), without significant differences in permanent hypoparathyroidism (1/5, 9/23 and 0/11, N.S.). After a median follow-up of 111 months, 20 of the 41 operated patients with long-term follow-up had persistent or recurrent hyperparathyroidism. We did not find differences in disease-free survival rates between different techniques, patients with or without permanent hypoparathyroidism and patients with different mutated exons, but a second surgery was more frequent after a less than subtotal parathyroidectomy.
Circadian clock genes and the transcriptional architecture of the clock mechanism
Authors: Cox Kimberly H , Takahashi Joseph S
Published: September 2019

The mammalian circadian clock has evolved as an adaptation to the 24-h light/darkness cycle on earth. Maintaining cellular activities in synchrony with the activities of the organism (such as eating and sleeping) helps different tissue and organ systems coordinate and optimize their performance. The full extent of the mechanisms by which cells maintain the clock are still under investigation, but involve a core set of clock genes that regulate large networks of gene transcription both by direct transcriptional activation/repression as well as the recruitment of proteins that modify chromatin states more broadly.
Infinite point and Riemann–Stieltjes integral conditions for an integro-differential equation
Authors: El-Sayed Ahmed , Gamal Reda
Published: September 2019

In this paper, we study the existence of solutions for two nonlocal problems of integro-differential equation with nonlocal infinite-point and Riemann–Stieltjes integral boundary conditions. The continuous dependence of the solution will be studied.
Existence of common fixed points for linear combinations of contractive maps in enhanced probabilistic metric spaces
Authors: Jafari Shahnaz , Shams Maryam , Ibeas Asier , De La Sen Manuel
Published: September 2019

In this paper, we introduce the concept of enhanced probabilistic metric space (briefly EPM-space) as a type of probabilistic metric space. Also, we investigate the existence of fixed points for a (finite or infinite) linear combination of different types of contractive mappings in EPM-spaces. Furthermore, we investigate about the convergence of sequences (generated by a finite or infinite family of contractive mappings) to a common fixed point. The useful application of this research is the study of the stability of switched dynamic systems, where we study the conditions under which the iterative sequences generated by a (finite or infinite) linear combination of mappings (contractive or not), converge to the fixed point. Also, some examples are given to support the obtained results. In the end, a number of figures give us an overview of the examples.
Modeling the uptake of fluorescent molecules into 3D cellular spheroids
Authors: Astrauskas Rokas , Ivanauskas Feliksas , Jarockytė Greta , Karabanovas Vitalijus , Rotomskis Ričardas
Published: September 2019

Three mathematical models were developed to analyze the dynamics of fluorescent dyes penetration into 3D cellular spheroids. Two fluorescent dyes were chosen to verify mathematical models: rhodamine 6G (R6G) as a small molecule, which can freely penetrate through the cells, and wheat germ agglutinin (WGA) conjugated with Alexa488 fluorescent label, which reacts with the cells plasma membrane, and its cellular penetration is significantly lower. Dye penetration and binding to cells were modeled with nonlinear diffusion–reaction equations. System of differential equations was solved using numerical methods, and good correspondence with physical experiment was shown. Diffusion coefficients in extracellular matrix were determined for both fluorescent dyes, and the influence of reactions parameters to WGA penetration was analyzed. Dynamics of dyes accumulation into cell spheroids were also determined.
EXTRAORDINARY COMMISSIONS AND THE CONTROL OF THE BOLSHEVIKS FOR THEIR ACTIVITY IN UKRAINE DURING THE CIVIL WAR (1918–1920)
Authors: Tykhonenkov D. A.
Published: September 2019

The article examines the connection between the Bolshevik political doctrine and the activity of the extraordinary commissions in the USSR in 1918–1920. The forms and methods of party control over the Cheka are shown. The mechanism of state terror in the context of the activity of the Cheka is investigated.
The legal basis of the activity of the extraordinary commissions is analyzed. Comparatively, the legal regulation of the control of extraordinary commissions by the party bodies and the practice of enforcement. The author analyzes the powers and functions of party bodies in the control over the activities of extraordinary commissions.
Information from archival sources on the activities of party control bodies of the CheK is provided. The author examines the mechanism of the formation of the Chekist bodies and the control of this activity by the Bolsheviks. Archival information on the national composition of a number of extraordinary commissions operating in the territory of Ukraine is provided. The normative basis for the formation of party bodies authorized to control the Chekist bodies is investigated.
The author describes in the article the characteristics of the activities of extraordinary commissions in Ukraine from the side of real eyewitnesses, participants in those events, party figures, and publicists of those times. The provisions of the secret documents issued by the authorities of the Soviet government with the aim of manually managing the activities of the Chekist bodies and its correct
coordination were provided. The author gives a number of statistical data on the results of the activity of party bodies in controlling the activities of the extraordinary commissions in Ukraine.
The genesis of the development of party control by the Bolsheviks over the activities of the Chekist bodies on the territory of Ukraine is explored. The author analyzes the relationship between the Communist Party of the Bolsheviks and the extraordinary commissions.
The process of involvement in the activities of extraordinary commissions of communist youth, the process of recruiting staff to their ranks is explored. The author presents archival information on the practice of bringing to justice the members of the Communist Party of the Bolsheviks.
The author considers this article as the first step towards rethinking the essence of “red terror”, its origins and mechanism of implementation from the standpoint of today.
Histoplasmosis: diagnostic challenges
Authors: Frías-De León María Guadalupe
Published: September 2019

Histoplasmosis is an infection usually caused by a fungal pathogen that, in most cases, occurs in the respiratory tract, which explains the high frequency of clinical manifestations in the lungs. (1) This mycosis is endemic in the Americas (Mississippi and Ohio River Valley, USA; Central and South America; and the West Indies), while reports in areas of Asia, Africa, Australia, and Oceania are mainly asso­ciated with the pandemic of acquired immune deficiency syndrome (AIDS). In Europe, cases are on the rise because of the speculation of a global distribution of histoplasmosis, and emphasis has been on improving methods for its diagnosis. (2,3)
Performance evaluation of a novel force measuring device for Friction Stir Welding (FSW) of aluminum alloys
Authors: Hoyos Pulgarín Elizabeth , Zuluaga-Posada María , Montoya Yesid
Published: September 2019

Friction Stir Welding (FSW) has the advantage of generating sound welds on materials that generally present low weldability by traditional fusion welding processes, such as 2xxx and 7xxx aluminum alloys. Force measurement in FSW provides significant information about the process, the machine requirements, the effect of selected parameters, and weld soundness. In this paper, an axial force measuring device was designed, built, and tested to be used in a CNC adapted system. All tests were performed using AA 7075-T6 and a butt joint configuration. The forces obtained by the device match, in profile, key values, and trends, the ones found in literature which allows to conclude that this is a functional and sufficient device for the application.
Incidence of mercerization treatment in the mechanical properties of bamboo fibre bundles "Guadua Angustifolia Kunth" from colombian origin
Authors: Quintero Giraldo Leidy Johana , Cruz Luis Javier , García Jaime Alexis , Alcaraz Alejandro , González Eugenia , Osorio Jairo Alexander
Published: September 2019

In this article, bamboo fibre bundles of "Guadua Angustifolia Kunth" specie were isolated from different locations of the basa zone: upper, middle and lower, through mechanical extraction method. The elastic modulus and the tensile strength were obtained with preliminary tensile tests. Applying the statistical analysis known as ANOVA, it was determined that the mechanical properties are similar in all the extension of the basa zone. From there, fibre bundles were extracted randomly, and a part of the fibre bundles was treated with NaOH (mercerization). Later, tensile tests with different calibration lengths were made for calculate the elastic modulus and the tensile strength of the treated and untreated fibre bundles. Best results belonged to the treated fibre bundles. A good correspondence between the results obtained in this work and the results reported in the literature was concluded.
Radiation forces study of a Laguerre Gaussian beam type TEM∗01 on a dielectric sphere in the Rayleigh scattering regime
Authors: Paez Amaya Darby , Molina Prado Martha Lucía , Arias Hernández Néstor Alonso
Published: September 2019

From the invention of the Optical Tweezer (OT) in 1986, these devices have been considered as high-level tools for research in the areas such as biology and microbiology. A theoretical study obtaining equations for gradient and scattering forces that exert an OT when the illumination beam is a doughnut-shaped mode TEM∗01 linearly polarized is realized. This work focuses on the behavior of radiation forces on a dielectric sphere in the Rayleigh regime. In order to facilitate the phenomenological analysis of the behavior of the radiation forces a graphical user interface is created.
Polymer adsorption isotherms with NaCl and CaCl2 on kaolinite substrates
Authors: Martínez Vertel Jaime José , Villaquirán-Vargas Ana Paula , Moreno Díaz Daniel Fernando , Villar García Álvaro , Rodríguez Castelblanco Astrid Xiomara
Published: September 2019

During polymer – flooding, polymer’s molecules are attached to the surface of the rock as a result of many interactions between both components, leading to a decrease on the injected slug’s concentration. This phenomenon, known as adsorption, depends on rock type, degree of hydrolysis and polymer concentration, reservoir’s temperature, water salinity, among others, and might be predicted by analytical models. This work shows the results of a series of static tests in which water’s salinity (NaCl and CaCl2) and polymer’s concentration were varied, to determine which of the analytical models can predict in a better way the experimental data when kaolinite substrates are used. It is discussed the abnormal trend of the adsorption, where higher NaCl concentrations resulted in lower adsorption results, basically because of a flocculation.
Reference framework for capabilities development in agricultural innovation systems
Authors: Romero Riaño Efren , Guarin Manrique Leidy Dayhana , Dueñas Gómez Monica Gisela , Becerra Ardila Luis Eduardo
Published: September 2019

Agricultural Innovation Systems (AIS) approach, arise as tool for better understanding dynamics and complexity of agricultural innovation. The dynamic approach of organizational capabilities development, is consolidated as a conceptual lens for AIS analysis, but not the systemic approach, which is considered emerging. The objective of this article is present a framework for AIS capability development, taking as a scientific reference, emerging economy countries experiences. A multi-dimensional methodology of literature review and content analysis is implemented, supported in bibliometric and data mining techniques. The networks analysis, the nonlinear perspective of innovation process and research, training, policy and brokering incidence over performance, are some of the main topics in common between AIS and capability development.
Development of a dynamic model for photovoltaic modules and arrays
Authors: Arias García Rodolfo Manuel , Perez Abril Ignacio
Published: September 2019

In the work, a dynamic model is proposed in Simulink, to model the behavior of photovoltaic modules and arrays. A novel methodology is proposed to obtain exactly the five parameters of the simple diode model, through the data provided by the manufacturer in the data sheet. The model proposes the calculation of the Volt-Ampere curve from environmental conditions, solar irradiance, ambient temperature and second-order effects, such as: the influence of temperature on the photocurrent generated and on the open circuit voltage, as well as the spectral and optical effects. The validity and accuracy of the proposed model is checked by comparing its results, with curves and experimental data from the manufacturer's data sheet. In addition, curves of the module are shown, allowing to evaluate its behavior taking in to account the optical and spectral effects.
Behaviour study of an eccentric pulley transmission system using systemic methods
Authors: Esnal Angulo Iñaki , Hernandis Ortuño Bernabé
Published: September 2019

This paper describes a case study carried out on the behaviour of an eccentric pulley transmission system housed in a manually operated abdominal-intestinal assistant device for human use. The aim is to establish a systemic framework that serves as a validation tool for mechanical systems in the initial stages of the product design processes. The proposed study system describes the device transmission process as a function of the input angle variation (dα), the height of the user’s feet (HF) and the pulley curvature function (C), resulting from the variation of its radius (dR) over time (dt). In order to explore and compare the different behaviours and identify possible solutions four different configurations of curvatures were proposed. Causal diagrams and differential equations describe the simulation scenario. The resulting application model supports the use of a systemic frame and methods as a pre-response to the validation of design proposals.
Sensory acceptance and shelf life of fresh cheese made with dry bromelain extract as a coagulating agent
Authors: Vergara Alvarez Windy Yolani , Arteaga- Márquez Margarita , Hernández-Ramos Elvis J.
Published: September 2019

The objective of this research was to evaluate the sensory acceptance and shelf life of a fresh cheese using dry bromelain extract as a coagulating agent. The dry bromelain extract was used in three concentrations (5%, 10% and 15% w / w) and the milk was used craw and pasteurized, for a total of six treatments under study. A sensory analysis was carried out and the useful life (sensorial, physicochemical and microbiological) of the treatment with greater acceptance was determined. The results showed that the cheeses obtained with greater sensory acceptance were those made with 5% w / w of bromelain dry extract regardless of the type of milk used (raw or pasteurized). The useful life of the selected product (T2) at the physicochemical level is 26 days, however sensory and microbiologically the product is of good quality until day 14. Therefore, the use of dry bromelain extract as a vegetable coagulant showed a great potential as a substitute for traditional rennet.
Rainfall thresholds for shallow landslides based on physical models: application in a sub-basin of the Valle de Aburrá (Colombia)•
Authors: Marín Roberto J. , García-Aristizábal Edwin , Aristizábal Edier
Published: September 2019

An analysis of the rainfall conditions and the influence of the infiltration processes on the slope stability are important in tropical mountain terrains due to the wide occurrence of rainfall-induced landslides. Distributed physical-based models can be coupled with techniques that relate the factor of safety with rainfall thresholds associated with the occurrence of this phenomenon. This study presents a methodology that determines the thresholds of rainfall intensity and duration, for the prediction of shallow landslides, using a distributed physical model called TRIGRS. In the analysis, it is used a percentage of the critical area of failure defined for a study area. The conditions of mean intensity and duration of rain that induce this failing area to be reached are adjusted to a potential equation, within certain ranges of duration and intensity. The model is used in a sub-basin of the Valle de Aburrá (Colombia) and the results are compared with rainfall thresholds defined with another distributed physical model. The obtained results reaffirm that the conditions of rainfall intensity and duration that trigger landslides in a region exhibit scaling properties determined by relationships of potential equations, like those obtained by other researchers in different places of the world.
Reclamation of salinized soils due to excess of fertilizers: evaluation of leaching systems and equations
Authors: Silva José Leôncio de Almeida , Duarte Sergio Nascimento , Da Silva Demetrius David , Miranda Neyton De Oliveira
Published: September 2019

In regions with intense irrigation, the use of fertirrigation increases crop productivity, but excessive fertilizer application increases the risk of soil salinization. Therefore, this work used leaching equations to evaluate systems of remediation of soils salinized by excess fertilizers. The phases of the study were: salinization of soils in lysimeters, remediation of these soils, and measurement of salt concentrations in soils for comparison with estimates of empirical equations. The treatments combined soil remediation systems (continuous and intermittent) with five initial levels of soil salinity (2.0, 4.0, 6.0, 8.0, and 10.0 dS m-1). The experimental design was randomized blocks with six replicates. The Volobuyev equation best represented the salinized soil remediation in relation to the results obtained experimentally. The equations tested showed better performance in the intermittent remediation system compared to the continuous system.
Microstructure, physical and mechanical properties of kaolin–diatomite composite reinforced with CaCO3•
Authors: ROA BOHÓRQUEZ KAROL LIZETH , VERA LÓPEZ ENRIQUE , FONSECA PÁEZ LUIS ALEJANDRO , PEÑA RODRÍGUEZ GABRIEL
Published: September 2019

The present work reports the microstructure, physical and mechanical properties of a material composed of kaolin, diatomite and calcium carbonate reinforcement (CaCO3). The ceramic prototypes were shaped by the slip casting method and sintered at temperatures between 800 °C and 1100 °C. The morphology and average pore size was analyzed by Scanning Electron Microscopy (SEM) and the mineralogical phases were determined by X-Ray Diffraction (XRD). The apparent density was established by the mercury immersion method according to the E – 8B Standard of the Institute of Ceramic Technology (ITC); the percentage of absorption was determined by the boiling method according to ISO 10545-3 standard; linear contraction was studied in three directions: long, wide and high. The study of the mechanical resistance to compression followed the procedure established at ASTM C773–88 standard and the breaking modulus was calculated by the three-point bending test, according to ISO 10545–4. Results show that the material structure is affected with increasing temperature reporting a decrease in quartz phase from 51.16 % to 33.81 %. Percentage of absorption revealed its most significant variation between 950 °C and 1100 °C with a decrease of 21 % approximately. Mechanical resistance values showed wide dispersion which was attributed to the different orientations in which the material failed during each test. According to the pore diameters found, the compound is characterized by being macro and mesoporous facilitating its application in catalysis, photochemistry, microelectronics and other microfiltration media
Urban logístics: origin of a strategy for creating shared value
Authors: Palacio-León Oscar
Published: September 2019

The city is the natural epicenter of a nation's economy. In it coexist not only a large number of extended enterprise but also a large part of the population of a country. Hence, stakeholders in the extended company as a socio-economic system based on the environment, should ensure that it is sustainable and enduring over time. For this reason, this article presents the design of a Win-Win business strategy, supported by a coordination mechanism through collaborative and cooperative contracts, based on the joint inventory in conditions of volatility, uncertainty, complexity and ambiguity, for an urban environment of an extended enterprise of shared economy. As a result, the efficient loading unit as a mechanism for creating shared value balances the technical-economic efficiency, between the contrasting make to stock and make to order strategies.
Reaction kinetic parameters for a distributed model of transport and reaction in Pd/Rh/CeZrO three-way catalytic converters
Authors: Rosero Chicaíza David Camilo , Hoyos Bibian A
Published: September 2019

This paper presents a two-dimensional distributed model for the transport and reaction of combustion gases in channels of three-way catalytic converters, considering a detailed reaction kinetics with 16 chemical reactions in palladium and rhodium catalysts, and taking into account diffusive effects within the coating, to obtain a new set of reaction kinetic parameters that do not depend on the thickness of the coating. The model was solved using a finite volume method with a first order upwind scheme and simulations were conducted using computational fluid dynamics. The model with the new distributed reaction kinetic parameters, produced an excellent agreement with the experimental data of concentration at the end of the channels. Also, the model reproduced the most important concentration changes for the gas components in the specified temperature range and allowed simulations with excess oxygen and different thicknesses.
Determination of the factors of variation of mean velocity in natural channels at steady state.
Authors: Constain Aragón Alfredo José , Peña-Olarte Gina Alexandra
Published: September 2019

From the Chezy-Manning equation, considered valid for the "steady state" of a natural channel, as an extension of the condition of "uniform flow," it is interesting to determine the degree of variation of the average flow velocity, depending on the variations of the factors involved. That is why this article presents a theoretical analysis which yields a first approximation of the sensitivity of the variation of the magnitude of the average speed to changes in the geometry or geomorphology of a section of the channel. It is found that the concept of "stable state" for the thermodynamic state of a natural channel can be assimilated to that of "dynamic equilibrium," in which the values of the state parameters vary slowly, in a "regional" sense.
Pediatric Dental Care in Fanconi Anemia: A Case Report
Authors: Gaitán-Fonseca DDS, MSc, PhD César , Frías-Muñoz DDS Maribel , Guerrero-de la Torre DDS Luis Enrique , Lemus-Rojero DDS, MSc Obed , Aguilera-Galavíz DDS, MSc, PhD Luis Alejandro
Published: September 2019

Fanconi Anemia (FA) is an autosomal-recessive genetic disease that is linked to Chromosome X, which is reported in studies with pancytopenia, congenital malformations, and a predisposition to develop cancer. FA 1,360,000 births, and is a condition that occurs in heterozygous subjects in 0.5% of the population. In Mexico, there are, to our knowledge, no epidemiological data on FA, and it is thought that many cases are underdiagnosed. This document reports the clinical case of a patient diagnosed with FA who   the cardinal signs of this rare pathology. The pediatric approach involved was performed with a preventive and restorative approach, in addition to the design and placement of a palatal shutter. After a follow-up of more than 12 months, a significant reduction in the recurrence of infections, such as otitis, tonsillitis, and pharyngitis, was observed, suggesting a positive influence of the use of the obturator. In turn with the latter, there was a lower need for transfusions, which may also be related to control of the foci of the infection. The pediatric approach employed in to patients with FA may have significant repercussions on both quality of life and on their patients’ general systemic condition, although this is scarcely verifiable due to the rarity of this pathology.
The effects of physical education on changes of basic motor skills of female students in the fifth grade of elementary school
Authors: Nikšić E. , Beganović E. , Rašidagić F. , Mirvić E. , Joksimović M.
Published: September 2019

Purpose: Thanks to the positive health effects of physical exercise, physical education is an integral part of the education system, with two hours per week, which is insufficient to achieve an optimal effect in transforming the anthropological status of children. The aim of the research was to determine the effects of regular and modified physical education with the application of contents from sports games (basketball, volleyball and handball) in the duration of one semester to changes in basic motor skills in pupils of the fifth grade of elementary school. Material: The study included N = 106 students of the V class, aged 10 to 11 years, clinically and mentally healthy, and with no pronounced morphological and locomotor impairments. The sample of examinees was divided into two subgroups. The first was an experimental group of 53 students, who carried out physical education classes according to the modified plan and program of sports games (basketball, volleyball and handball) for a semester. The other was a control group of 53 students who attended regular classes from physical education according to the current curriculum. Results: The results of the research at the descriptive level showed noticeable differences between the same groups in the final versus the initial measurements. Based on the results of the t-test for the control and experimental group, it can be concluded that there have been statistically significant changes in values on all variables of basic motor in the final compared to the initial measurement. By analyzing the results of the t-tests, it can be seen that the groups differ in the initial measurement only in one basic motor variable, MTAPN, and this difference is statistically significant in favor of the control group. In the final measurement, there are no significant differences between the control and the experimental group in the average values of all variables of basic motoring. Conclusions: Improving basic motor skills depends on the teacher's ability, the ability to transform the age with which he is working, and the success of certain training processes. The modified program of the experimental group has led to changes and thus proves the significant effect of the group's work program.
APOL1 Kidney Risk Variants Induce Cell Death via Mitochondrial Translocation and Opening of the Mitochondrial Permeability Transition Pore
Authors: Shah Shrijal S. , Lannon Herbert , Dias Leny , Zhang Jia-Yue , Alper Seth L. , Pollak Martin R. , Friedman David J.
Published: September 2019

Significance Statement

Some variants in APOL1 are associated with high CKD rates in African Americans, but the molecular mechanism of disease remains elusive. Previous studies demonstrated that expression of APOL1 risk variants is associated with mitochondrial dysfunction. In this study, the authors show that import of APOL1 protein into mitochondria is essential for risk variant–mediated cytotoxicity, and map the APOL1 import pathway. They found that whereas APOL1 is mostly monomeric, risk variant APOL1 can form large oligomers and cause opening of the mitochondrial permeability transition pore, ultimately leading to cell death. This difference in propensity of different variants to oligomerize could help explain APOL1 risk variants’ gain-of-function biology despite a recessive mode of inheritance. Understanding APOL1 trafficking and interactions could help inform new therapeutic approaches.

Background

Genetic Variants in Apolipoprotein L1 (APOL1) are associated with large increases in CKD rates among African Americans. Experiments in cell and mouse models suggest that these risk-related polymorphisms are toxic gain-of-function variants that cause kidney dysfunction, following a recessive mode of inheritance. Recent data in trypanosomes and in human cells indicate that such variants may cause toxicity through their effects on mitochondria.

Methods

To examine the molecular mechanisms underlying APOL1 risk variant–induced mitochondrial dysfunction, we generated tetracycline-inducible HEK293 T-REx cells stably expressing the APOL1 nonrisk G0 variant or APOL1 risk variants. Using these cells, we mapped the molecular pathway from mitochondrial import of APOL1 protein to APOL1-induced cell death with small interfering RNA knockdowns, pharmacologic inhibitors, blue native PAGE, mass spectrometry, and assessment of mitochondrial permeability transition pore function.

Results

We found that the APOL1 G0 and risk variant proteins shared the same import pathway into the mitochondrial matrix. Once inside, G0 remained monomeric, whereas risk variant proteins were prone to forming higher-order oligomers. Both nonrisk G0 and risk variant proteins bound components of the mitochondrial permeability transition pore, but only risk variant proteins activated pore opening. Blocking mitochondrial import of APOL1 risk variants largely eliminated oligomer formation and also rescued toxicity.

Conclusions

Our study illuminates important differences in the molecular behavior of APOL1 nonrisk and risk variants, and our observations suggest a mechanism that may explain the very different functional effects of these variants, despite the lack of consistently observed differences in trafficking patterns, intracellular localization, or binding partners. Variant-dependent differences in oligomerization pattern may underlie APOL1’s recessive, gain-of-function biology.
Retrospective Evaluation Of Children After Stem Cell Transplantation: Single Center Experience
Authors: GÜNGÖRER Vildan , YILMAZ KESKİN Ebru , FIŞGIN Tunç
Published: September 2019

AbstractAim: Analysis of the data of children following stem cell transplantation.Materials and Methods: A total of 44 children who received stem cell
transplant between February 2009 and May 2011 were evaluated retrospectively. Results: Among the patients with a mean age of 9.6 ± 4.63 years, 20 (45.5%) were male, whereas 24 (54.5%) were
female. The initial diagnosis of the patients with decreasing order of
frequency was as follows: thalassemia major (n=15), acute leukemia (n=9),
Fanconi aplastic anemia (n=6), aplastic anemia (n=5) and other disorders (n=9).
Disease-free survival in two years was observed in 27 (61.3%) of patients.
Relapse occurred in 8 (18.1%) patients, whereas 9 (20.4%) patients died. The
mortality was transplant-related in two cases, whereas it was due to
progression of the underlying disease in 7 (15.9%) patients.

Conclusion: As the stem cell transplantation has become widespread
in Türkiye recently, its data are valuable. We found high incidence of
mucositis and infection due to myeloablative regimens. The limitation of our
study is the small number of patients included. 
Though, results obtained here are similar to those of national and
international studies.
Economic and mathematical modeling as an effective tool of the analysis of economic processes in industry
Authors: Kulyasova A. S. , Esina A. R. , Svirchevskiy V. D.
Published: September 2019

In conditions of market volatility, an important issue for industrial enterprises is the issue of creating an efficient resource allocation mechanism. The article gives an example about using of individually adapted economic and mathematical model for forecasting the cost of materials and purchased products, that takes into account both internal and external factors affecting the planning figures. In order to create an effective predictive model, an analysis was conducted of statistical data for the period from 2009 to 2016, data was represented by high-tech enterprises of the radioelectronic industry. As a result of analysis it was revealed the presence of statistical regularities in the nature of the distribution of the analyzed data.

On the basis of the calculated distribution parameters, a prediction procedure was performed using the exponential smoothing method and the total projected cost of materials and purchased products was obtained. The use of elements of probability theory and mathematical statistics, as well as methods for forecasting time series as basic methods of the model allows to take into account probabilistic economic factors, such as, for example, a change in the exchange rate of a foreign currency, as well as the presence of defects in the production process. Application of a special mathematical apparatus provides an ability to create a flexible, individually-adapted forecasting model. As a result of application of the model intended for forecasting the cost of materials and purchased products at one of industry enterprises it was revealed that the developed model has lover calculation error than the method that is used at the enterprise at present. Thus economic and mathematical model allows increasing the efficiency of the enterprise’s planned system and ensuring a rational resource allocation by increasing the accuracy of the forecasting process.
Metodologias ativas no ensino superior: o hibridismo da sala de aula invertida
Authors: Dos Santos Colvara Jonas , Do Espirito Santo Eniel
Published: September 2019

Neste artigo discutimos a utilização das metodologias ativas, abordando o hibridismo tecnológico da sala de aula invertida no ensino superior e seus desafios relacionados. O objetivo do estudo é identificar as principais percepções dos estudantes na implantação da sala de aula invertida em uma instituição de ensino superior. Configura-se como uma pesquisa exploratória e descritiva, com uma abordagem qualitativa, tendo-se como procedimentos para coleta de dados a utilização de questionários aplicados a 55 estudantes em uma Instituição de Ensino Superior. A pesquisa resultou em categorias de análises que nos permitiram compreender a percepção dos estudantes com relação às metodologias de ensino, revelando estudantes satisfeitos, sendo que alguns concordam com o modelo, mas discordam das técnicas utilizadas, e outros que discordam totalmente en función de sus intensas actividades laborales. Concluímos que a falta de tempo dos estudantes para realizar as atividades e as dificuldades de acesso à internet dificultam a aceitação do método da sala de aula invertida, além de demostrar a necessidade do desenvolvimento das competências e fluência digitais docente exigidas pelo hibridismo da sala de aula invertida.
New B.ED. Programme in India: A Convergent Parallel Study on ICT-Integration
Authors: Kanvaria Vinod Kumar , Nagpal Bharti
Published: September 2019

O presente trabalho visa a explorar e compartilhar a integração das TICs e a sua condição no novo programa de dois anos de bacharelado em educação (B.Ed.), o qual foi implementado em 2015, na Índia, por meio de um órgão regulatório chamado Conselho Nacional para a Formação de Professores (NCTE). O projeto de pesquisa convergente de método misto paralelo foi utilizado nesse estudo, no qual os pesquisadores coletaram dados qualitativos e quantitativos simultaneamente e compararam ou convergem ambos os tipos de dados para obter um entendimento aprofundado relacionado ao problema de pesquisa. Amostragem aleatória estratificada, amostragem intencional, amostragem aleatória sistemática e técnicas de amostragem convencional foram usadas de acordo com a necessidade de vários grupos de amostras. O resultado principal do estudo foi descrever os processos e as práticas atuais bem como as recomendações futuras para a integração de TICs no novo programa de bacharelado implementado em 2015 na Índia. Os esclarecimentos resultados desse estudo podem ser implementados em outros países ao redor do mundo.
Protein gel sample preparation v1
Authors: B. Cleo
Published: September 2019

Sample preparation for tricine SDS-page gels and polyacrylamide SDS-page gels.
Protein purification strep-tag on gravity column v1
Authors: B. Cleo
Published: September 2019

Protein purification of a protein with a strep-tag on a gravity column.
Cerca y lejos del indio: cuatro novelas históricas de tema indígena en Antioquia (1896-1993)
Authors: Orrego Arismendi Juan Carlos
Published: September 2019

en el amplio corpus de la novela latinoamericana de tema indígena, diverso temática y formalmente, pueden establecerse periodos y procesos regulares que dejan clasificar y relacionar algunas obras de modo inteligible. En el caso antioqueño, el estudio concentrado de cuatro novelas históricas deja ver —cuando se las observa en su sucesión cronológica— las diversas maneras en que el mito se funde con la narración histórica. Esa evolución se traduce en un proceso de acercamiento gradual al universo indígena que, sin alcanzar su culminación, deviene en alejamiento.
Eco-ficciones americanas: crisis ambiental y social en La novia oscura (1999) de Laura Restrepo y Le Club des miracles relatifs (2016) de Nancy Huston
Authors: Averis Kate
Published: September 2019

este artículo analiza la relación entre degradación ambiental y crisis social en dos eco-ficciones americanas recientes: La novia oscura (1999) de Laura Restrepo y Le Club des miracles relatifs (2016) de Nancy Huston. Adoptando un acercamiento comparatista y ecocrítico, el análisis demuestra las intersecciones entre la consciencia ecológica y las estrategias narrativas que se observan en estas dos narrativas que presentan crisis ambientales y sociales fundadas en las relaciones entre degradación ambiental, masculinidades hegemónicas y violencia de género. El análisis concluye con una discusión de esta tríada en relación a las ecologías naturales, culturales y humanas de las dos novelas.
As tutelas de urgência na judicialização da saúde e a medicina baseada em evidências
Authors: Tavares Luiz Marcelo Cabral
Published: September 2019

This essay aims to address the issue of judicialization of health, more specifically the granting of emergency relief; the use of evidence-based medicine as an alternative to alleviate this institutional crisis; and foster debate around viable proposals to minimize the deleterious impacts of judicialization on health system management.
Coletânea Direito à saúde: boas práticas e diálogos institucionais
Authors: Alves Juliane Aparecida
Published: September 2019

The compendium presents, briefly, the thematic responsibilities of the National Council of Health Secretaries - CONASS, as well as its functional premises and strategies used to fulfill the Council's objectives, one of them being publications of collective authorship, as has been since 2015. These publications include contributions from state health department officials, university professors, judges, auditors of the Federal Court of Audit (TCU, in Portuguese), prosecutors, state prosecutors, judges specializing in the right to health, which present the need for increased institutional dialogues and good health practices.