bluuebunny/crossref_metadata_2025 huggingface dataset:
PENATAAN RUANG DAGANG PADA PERANCANGAN PASAR WISATA KOTA BATU
Authors: Maharani Caeska
Published: August 2021

Seiring dengan perkembangan dan kemajuan zaman terjadi perubahan tuntutan dan standar konsumen terhadap pasar tradisional, guna mewujudkan fungsi pasar tradisional yang lebih baik, lebih sehat dan lebih nyaman. Pasar Kota Batu merupakan salah satu penyumbang restribusi Pendapatan Asli Daerah (PAD) Kota Batu yang tinggi, namun hal tersebut tidak diimbangi dengan aspek kenyamanan yang mencangkup penataan ruang dagang. Pada Pasar Kota Batu penataan ruang dagang pada penjual kebutuhan sehari-hari masih bercampur aduk, tidak terbagi per zonasi. Kajian penataan ruang dagang merupakan merespon suatu permasalahan yang maih banyak terjadi di pasar tradisional Indonesia, yaitu ruang dagang yang tidak teratur, kotor, kurang terawat, dll. Kajian dengan perumusan berdasarkan dengan standar SNI dan Keputusan Menteri Kesehatan Republik Indonesia nomor 519 tahun 2008 tentang pedoman penyelenggaraan pasar dan berorientasi kepada masyarakat sebagai penggunanya. Untuk mengetahui penyebab permasalahan penataan ruang dagang yang kurang baik dilakukan analisis berdasarkan kriteria-kriteria pasar tradisional. Metodelogi penelitian yang digunakan adalah dengan pendekatan metodologi kualitatif yang selanjutnya akan dianalisis. Perwujudan dari aspek-aspek tersebut untuk mendapatkan hasil perancangan penataan ruang dagang Pasar Wisata Kota Batu yang bercitra modern dan dapat mengembalikan daya saing pasar tradisional.
TEMPAT PENGELOLAAN SAMPAH (R3) DI KAWASAN PASAR BESAR KOTA BATU DENGAN PENDEKATAN ARSITEKTUR EKOLOGIS
Authors: Ruslin Jenisa Karenata Zabrina , DS Dermawati , Rosnarti Dwi
Published: August 2021

Pengelolaan sampah berbasis R3 merupakan satu upaya menangani masalah sampah di kota besar. Sistem R3 merupakan kegiatan mengurangi (Reduce), menggunakan kembali (Reuse) dan mendaur ulang sampah (Recycle). Sistem pengelolaan sampah R3 mampu mengurangi volume sampah, dan menghadirkan nilai ekonomi. Sistem ini harus dilengkapi dengan ketersediaan sarana dan prasarana. Tujuan penelitian ini menganalisa ketersediaan tempat pengelolaan sampah yang layak dengan sistem R3 untuk diterapkan pada kawasan Pasar Besar Batu. Metode yang dilakukan merupakan metode kuantitatif berupa tabel, gambar, skematik, dan pendekatan deduktif. Analisis studi menunjukkan bahwa hampir seluruh TPS memerlukan standar ruang dengan prinsip arsitektur ekologis dan proses pengelolaan sampah yang ideal menggunakan sistem R3.
PENERAPAN ARSITEKTUR HIJAU PADA BANGUNAN APARTEMEN DENGAN PENGGUNAAN KAYU SEBAGAI DOUBLE SKIN FACADE
Authors: Fathia Zahra , Pribadi I. G. Oka Sindhu , Utami Laksmi
Published: August 2021

Indonesia termasuk salah satu negara yang memiliki iklim tropis dengan curah hujan dan panas yang tinggi. Suhu panas yang tinggi akan membuat bangunan juga terasa panas. Penggunaan Double Skin Facade (DSF) pada eksterior bangunan bisa menjadi salah satu solusi untuk mengatasinya. Maraknya pembangunan di Indonesia merupakan salah satu yang dapat menyebabkan terjadinya pemanasan global. Salah satu cara adalah dengan menerapkan konsep arsiktetur hijau pada bangunan. Maka untuk menerapkannya, Double Skin Facade membutuhkan material yang ramah lingkungan dan terbarukan seperti material kayu. Tujuan penelitian ini adalah untuk mengeksplorasi penggunaan material kayu sebagai Double Skin Facade pada bangunan apartemen. Penelitian dilakukkan dengan menggunakan pendekatan deskriptif kualitatif dan metode studi banding. Perwujudan dari aspek-aspek tersebut untuk mendapatkan hasil desain double skin facade dengan menggunakan material kayu.
Acolhimento de gestantes e puérperas suspeitas ou confirmadas de COVID-19 em uma maternidade de referência
Authors: França Josineide de Oliveira Novo , Galvão Drielly da Silva , Holanda Aldina Iacy Paulain , Guimarães Jackeline Vieira , França Neil Silva de , Reis Nailu Flor Chenini de Carvalho , Jacauna Vitória Karoline Maciel , Cardoso Silvani Vieira , Pereira Maria Suely de Souza , Ferreira Alaidistania Aparecida
Published: August 2021

Objetivo: Relatar a experiência obtida por residentes de enfermagem obstétrica, frente a nova realidade instalada no atendimento à mulher no ciclo gravídico-puerperal, em uma maternidade, durante a pandemia de COVID-19. Relato de experiência: Foi produzido a partir da vivência das residentes do programa de enfermagem obstétrica vinculado à uma universidade pública do Amazonas que atuaram em uma maternidade de referência no atendimento às mulheres no ciclo gravídico puerperal com suspeita ou confirmação de infecção por COVID-19 no período de junho de 2020 a junho de 2021. A pandemia da COVID-19 impôs readequações nos atendimentos das residentes de enfermagem obstétrica às mulheres no ciclo gravídico puerperal assistidas na maternidade, dificuldades enfrentadas pelos profissionais de enfermagem no atendimento às gestantes e puérperas com suspeita ou confirmação de COVID- 19, assim como, o aprimoramento da assistência mediante o novo cenário.  Considerações finais: Em decorrência da pandemia de COVID-19 os protocolos de atendimento às mulheres no ciclo gravídico puerperal foram modificados e adaptados, no entendimento de que os profissionais de saúde precisam aplicar estratégias atualizadas para prestar assistência segura e humanizada às pacientes acolhidas na maternidade.
Avaliação da hiperlactatemia em pacientes com diagnóstico de choque séptico
Authors: Gatti Júlia Domingues , Guimarães Aline Vieira , Paranaíba Aline Vilela de Oliveira , Ferrazzo Flavia , Melo Isabella Orlc Figueiredo , Stavro Larissa Giacomelli , Mendes Letícia Freire Rettore , Marcon Victória Gabriela , Thomaz Vitória Miranda , Corrêa Mônica Isaura
Published: August 2021

Objetivo: Realizar uma revisão da literatura acerca de como o aumento do lactato arterial pode influenciar no prognóstico dos pacientes em quadro de choque séptico. Revisão bibliográfica: O choque séptico é definido como uma condição clínica em que o paciente apresenta a necessidade de vasopressor para manter uma pressão arterial média (PAM) de 65mmHg ou mais, e o nível de lactato sérico se encontra maior que 2mmol/L. O lactato é produzido devido a uma resposta de hipoperfusão tecidual, através do metabolismo anaeróbio, e em condições fisiológicas anormais é um composto utilizado como parâmetro do equilíbrio de oxigênio. Além disso, a redução em 10% no valor do lactato é responsável por diminuir cerca de 11% na taxa de mortalidade. Considerações finais: O lactato arterial elevado mostrou-se relacionado ao aumento da taxa de mortalidade, ou seja, quanto maior o nível do composto pior é o prognóstico. Para isso, o diagnóstico precoce e medidas terapêuticas rapidamente instruídas são necessárias para aumentar a taxa de sobrevida dos pacientes em choque séptico.
Application of adaptive identification methods for refining parameters of radiation pressure models
Authors: Черникова Оксана Сергеевна , Толстиков Александр Сергеевич , Четвертакова Юлия Сергеевна
Published: August 2021

Представлены две адаптивные модификации сигма-точечного фильтра Калмана с рекуррентным оцениванием ковариационных матриц шумов системы и измерений, на основе которых выполняется процедура параметрической идентификации нелинейных непрерывно-дискретных систем. Применение процедуры адаптивной параметрической идентификации позволило вычислить с достаточной точностью оценки параметров нескольких моделей радиационного давления солнечного излучения. Полученные результаты повысили качество прогнозирования траектории движения навигационного спутника

Purpose. The paper considers the problem of estimation of unknown parameters for various models of solar radiation based on adaptive modifications of the unscented Kalman filter. The estimations of the obtained parameters are used both in solar radiation models and in construction of trajectory of a navigation satellite. Methodology. To solve the problem of parametric identification of stochastic nonlinear continuous-discrete systems, several adaptive modifications of the unscented Kalman filter are considered. The algorithms assume recurrent estimation of covariance matrices of system noise and measurements. The maximum likelihood method is used for parametric identification of stochastic nonlinear continuous-discrete systems. Adaptive modifications of the unscented Kalman filter are used in the construction of the identification criterion. Estimates of unknown parameters of various solar radiation models are found for the movement for the navigation satellite model as an example. The satellite orbital movement forecast is made. Finding and value. The application of the adaptive parametric identification procedure allows calculating the estimates for the parameters of several models of the solar radiation with sufficient accuracy. The obtained results lead to significant improvement of quality of the prediction for satellite trajectory
Square-root algorithms for robust modifications of the continuous-discrete cubature Kalman filter
Authors: Чубич Владимир Михайлович , Кулабухова Светлана Олеговна
Published: August 2021

Предложены две устойчивые к ошибкам машинного округления и к аномальным данным квадратно-корневые модификации непрерывно-дискретного кубатурного фильтра Калмана, основанные на вариационном байесовском и коррентропийном подходах. Апробация разработанных алгоритмов на модельной задаче со случайным характером расположения аномальных наблюдений показала их работоспособность при сопоставимом качестве фильтрации. Подтверждена алгебраическая эквивалентность представленных квадратно-корневых и стандартных версий

Rounding errors due to the finite length of machine word can significantly affect the quality of estimation and filtering when solving the corresponding problems in various subject areas. In this regard, to improve the reliability of the obtained results, it is advisable to develop and then apply square-root modifications of the used algorithms. Purpose: developing the square-root modifications of the continuous-discrete cubature Kalman filter on the basis of variational Bayesian and correntropy approaches. Methodology: matrix orthogonal QR decomposition. Findings: two robust (resistant to the possible presence of anomalous data and to machine rounding errors) modifications of the continuous-discrete cubature Kalman filter have been developed. The first (variational Bayesian) algorithm is obtained by extending the known discrete equations of the extrapolation stage to the continuous-discrete case. The second algorithm, based on the maximum correntropy criterion, is proposed in this paper for the first time. The developed square-root algorithms for nonlinear filtering are validated on the example of one stochastic dynamical system model with the random location of anomalous observations. In doing so, the filtering quality, estimated by the value of the accumulated mean square error, was quite comparable for both modifications during equivalent results obtained for the corresponding root-free analogues. Value: the proposed square-root versions of robust modifications of the continuous-discrete cubature Kalman filter are algebraically equivalent to their standard analogues. Meanwhile, positive definiteness and symmetry of covariance matrices of the state vector estimates at the extrapolation and the filtration stages are provided. The developed algorithms will be used to develop software and mathematical support for parametric identification of stochastic nonlinear continuous-discrete systems in the presence of anomalous observations in the measurement data
Optimization of a mode-locked fiber laser based on nonlinear polarization rotation using genetic algorithm
Authors: Художиткова Дарья Алексеевна
Published: August 2021

Выполнено математическое моделирование волоконного лазера с синхронизацией мод на основе эффекта нелинейного вращения поляризации. Проведена оптимизация лазера с использованием генетического алгоритма. В результате были определены параметры лазерного резонатора, при которых достигается наибольшая энергия выходного импульса

Purpose. The article addresses optimization of mode-locked fiber laser based on nonlinear polarization rotation. Determination of the resonator parameters corresponding to the single-pulse with the highest energy has been performed using the genetic algorithm. Metodology. Mathematical modelling has been carried out with the help of two models, namely, scalar and hybrid. Scalar model describes signal propagation by generalized nonlinear Schr¨odinger equation. Hybrid model describes section of DCF by pair of generalized nonlinear Schrodinger equations. Numerical simulation has been performed by the split-step Fourier method. Genetic algorithm has been implemented as SteadyState method by GALib library. The value of the fitness function is equal to the energy value for the single-pulse and otherwise zero. Findings. The genetic algorithm has been implemented for solving optimization problem of fiber lasers and modifying the algorithm to reduce the calculation time. The parameters of the laser for the scalar model are determined and agreement with the results obtained by the enumeration method is presented. For the hybrid model, a stable pulse with three times the energy was found. Conclusions. In this work, a determination of the optimal parameters for mode-locked fiber lasers based on nonlinear polarization rotation was presented. The problem was solved using a genetic algorithm. This is the first step towards creating a “smart” self-tuning laser
The determination of the total atmospheric water vapor content over the oceans using the MTVZA-GY microwave radiometer measurements
Authors: Косторная Анжелика Андреевна , Рублев Алексей Николаевич , Голомолзин Владимир Викторович
Published: August 2021

Представлена методика определения интегрального влагосодержания в безоблачной атмосфере над океанскими и морскими акваториями по измерениям микроволнового радиометра МТВЗА-ГЯ, устанавливаемого на российских гидрометеорологических спутниках серии “Метеор-М”. Определение влагосодержания осуществляется с помощью регрессий, предикторами которых являются измеренные интенсивности излучения в выбранных каналах радиометра. В их число могут входить каналы с рабочими спектральными диапазонами внутри и вне полос поглощения водяного пара. Адаптивный поиск оптимального набора каналов для различных районов земного шара проводится в зависимости от типа поверхности и климатической зоны. Критерием выбора каналов и вида регрессии является минимальная среднеквадратичная невязка получаемых оценок влагосодержания атмосферы с контрольными значениями, рассчитанными по данным реанализа Национального центра экологического прогнозирования (NCEP) и специальных атмосферных моделей, разработанных в Европейском центре среднесрочных прогнозов погоды (ECMWF)

The determination of the total atmospheric water vapor content over the cloudless ocean using the MTVZA-GY measurements in microwave range is described. The microwave scanning radiometer MTVZA-GY is located on the Russian meteorological satellites “Meteor-M” and outgoing radiation of the surface-atmosphere system is measured in 29 channels. To calculate the integrated water vapor, the adaptive searching of the optimal set of channels using regression analysis was proposed. Frequencies that are not related to water-vapor absorption lines are used as predictors. The minimum of total approximation error was obtained for selected channels and corresponding regression coefficients values. The quality control of retrieval integrated water vapor (kg/m) was conducted with the help of the set of atmospheric profiles obtained by M. Matricardi and NCEP/NCAR Reanalysis as a priori data using the proposed method. Standard deviations (RMS) obtained by determined adaptive search for the predictors are about 3 kg/m2. Application of the method for cloudless water areas allowed finding a set of 6 channels MTVZA GY (18.7H, 23.8V, 23.8H, 57+0.32+0.025H, 57+0.32+0.01H и 183+1.4V) for which the RMS values are minimal - 4.4 kg/m. The use of all channels of the device in the search allows reducing the error in determining the integrated water vapor content. The proposed method for recovering the content of water vapor from measurements in the channels of the MTVZA-GYa device allows an adaptive search for an optimal set of channels for different regions of the globe and find the best combinations for various climatic zones and surface types
Convergence behavior of popular schemes in case of calculating on adaptive grids problems with layers
Authors: Лисейкин Владимир Дмитриевич , Паасонен Виктор Иванович
Published: August 2021

Проведено сравнение качества решений модельного уравнения второго порядка с малым параметром, полученных по трем различным разностным схемам на специальных адаптивных сетках, явно задаваемых координатным преобразованием, а также на равномерных сетках в новых переменных, соответствующих этому преобразованию. Исследуются схемы второго порядка точности с диагональным преобладанием и без него и простейшая противопотоковая схема. На основе оценок погрешностей сделаны прогнозы относительно свойств решений, подтвержденные анализом и численными экспериментами. Показано, что схема второго порядка аппроксимации с диагональным преобладанием сходится равномерно по малому параметру со вторым порядком лишь в частном случае, когда коэффициент при старшей производной мал только в слое; если же он мал также и вне слоя, порядок сходимости первый. Установлено также, что схема без диагонального преобладания имеет существенно более качественные решения без осцилляций в новых переменных на равномерной сетке, чем в соответствующих им исходных физических координатах. В противоположность ей схемы с диагональным преобладанием не чувствительны к выбору системы координат.

The paper compares solution quality to some model second- order equation with a small parameter obtained through three different schemes both on special adaptive grids specified explicitly by coordinate transformations eliminating layers and on uniform grids in a new coordinate related to the transformations. The schemes up to second order in physical and transformation variables both with a diagonal and not diagonal dominance and the simplest counter-flow scheme are analyzed. Predictions of a solution behavior based on estimates of solution errors are described, which are confirmed by numerical experiments and proofs. It is established, in particular, that the scheme of the second order with a diagonal dominance converges uniformly if the coefficient before the second derivative is small at the points of the boundary layer only. It was also demonstrated for the schemes without a diagonal dominance, mach better solutions without oscillations are obtained on uniform grids in new variables than on corresponding adaptive grids in the original physical coordinates.
The explicability factor of the algorithm in the problems of searching for the similarity of text documents
Authors: Краснов Федор Владимирович , Смазневич Ирина Сергеевна
Published: August 2021

С развитием все более сложных методов автоматического анализа текста повышается важность задачи объяснения пользователю, почему прикладная интеллектуальная информационная система выделяет некоторые тексты как схожие по смыслу. В работе рассмотрены ограничения, которые такая постановка накладывает на используемые интеллектуальные алгоритмы. Проведенный авторами эксперимент показал, что абсолютное значение схожести документов не универсально по отношению к интеллектуальному алгоритму, поэтому оптимальную пороговую величину схожести необходимо устанавливать отдельно для каждой решаемой задачи. Полученные результаты могут быть использованы при оценке применимости различных методов установления смысловой схожести между документами в прикладных информационных системах, а также при выборе оптимальных параметров модели с учетом требований объяснимости решения.

The problem of providing a comprehensive explanation to any user why the applied intelligent information system suggests meaning similarity in certain texts imposes significant requirements on the intelligent algorithms. The article covers the entire set of technologies involved in the solution of the text clustering problem and several conclusions are stated thereof. Matrix decomposition aimed at reducing the dimension of the vector representation of a corpus does not provide clear explanatiom of the algorithmic principles to a user. Ranking using the TF-IDF function and its modifications finds a few documents that are similar in meaning, however, this method is the easiest for users to comprehend, since algorithms of this type detect specific matching words in the compared texts. Topic modeling methods (LSI, LDA, ARTM) assign large similarity values to texts despite a few matching words, while a person can easily tell that the general subject of the texts is the same. Yet the explanation of how topic modeling works requires additional effort for interpretation of the detected ones. This interpretation gets easier as the model quality grows, while the quality can be optimized by its average coherence. The experiment demonstrated that the absolute value of documents similarity is not invariant for different intelligent algorithms, so the optimal threshold value of similarity must be set separately for each problem to be solved. The results of the work can be further used to assess which of the various methods developed to detect meaning similarity in texts can be effectively implemented in applied information systems and to determine the optimal model parameters based on the solution explicability requirements.
Application of minimal mathematical models for the dynamics of the signaling pathway of the p53 - miRNA to the analysis of laboratory data
Authors: Сенотрусова Софья Дмитриевна , Воропаева Ольга Фалалеевна , Шокин Юрий Иванович
Published: August 2021

Работа посвящена практическому использованию минимальных математических моделей динамики сигнального пути p53 для описания достаточно широкого круга лабораторных экспериментов, в которых взаимодействие p53 и белковингибиторов p53 опосредуется микроРНК, образующими с p53 петлю положительной обратной связи. Представлены базовая модель, разработанные на ее основе новые минимальные модели, алгоритм численного решения прямых и обратных коэффициентных задач и результаты сопоставления полученных численных решений с экспериментальными данными о динамике уровней белков p53, p21, Bax, белков-ингибиторов Mdm2, Wip1, Sirt1 и различных микроРНК (miR-16, miR-34a, miR-192, miR-194, miR-215) в условиях стрессовых воздействий. С привлечением полученных математических моделей исследованы базовые механизмы функционирования сигнального пути p53 в условиях, приближенных к условиям конкретных лабораторных экспериментов in vitro и in vivo. Продемонстрированы синергический эффект гиперактивации сигнального пути p53, в котором задействованы микроРНК, и механизмы бимодального переключения. Показана ключевая роль p53-зависимых микроРНК в реализации некоторых гипотетических терапевтических стратегий, связанных с управлением механизмом активации апоптоза клеток. В рамках принятой базовой модели даны оценки вероятности рассогласования в диагностике дегенеративных заболеваний, основанной на анализе уровня p53зависимых микроРНК и p53, при слабой и умеренной дерегуляции микроРНК.

This study addresses the practical use of minimal mathematical models of the dynamics of a hypothetical system of the p53 signaling pathway to describe a fairly wide range of laboratory experiments. In such system, the interaction of p53 and p53 inhibitor proteins is mediated by microRNAs that form a positive feedback loop with p53. A basic model, new minimal models developed on its basis, an algorithm for the numerical solution of direct and inverse coefficient problems, and the results of comparing the obtained numerical solutions with experimental data on the dynamics of the levels of p53, p21, Bax proteins, inhibitor proteins Mdm2, Wip1, Sirt1, and various microRNAs (miR-16, miR-34a, miR-192, miR-194, miR-215) under stress conditions are presented. In numerical experiments, the main mechanisms of the p53 signaling pathway were investigated. A synergistic effect of hyperactivation of the p53 signaling pathway and bimodal switching mechanisms has been demonstrated. We show the key role of p53-dependent microRNAs in the implementation of some hypothetical therapeutic strategies associated with the control mechanism for activation of cells apoptosis. Within the framework of the accepted basic model, we estimated the probability of mismatch in the diagnosis of the patient’s status. The status is based on the analysis of the level of p53-dependent microRNAs and p53, with weak and moderate deregulation of microRNAs.
The Value of Collaboration between Psychiatrists and Exorcist Priests
Authors:   Uniwersytet Papieski Jana Pawla II w Krakowie (John Paul II Pontifical University in Kraków), Kraków, Poland, OV Anna M Noworol
Published: August 2021

The article presents the issues of cooperation between psychiatrists and exorcist priests, taking into account the psychiatrist, exorcist priest, patient, and the unusual disease of possession, paying particular attention to when and why the cooperation is essential. And it is necessary mainly in difficult cases of possession. Possession does not only exist as another mental illness; possession is a parapsychological disease, an unusual disease in which supernatural phenomena occur, and is therefore more than a patient’s conviction that he or she will be subjected to demons. Possession is the real seizure of the possessed body by an evil spirit. Possession needs a specific diagnosis and treatment, by a unique specialist, which is an exorcist priest. For the work of exorcist priests, it is very important the cooperation with psychiatrists, who recognize and treat cases of pseudo-possessions and mental illnesses that may coexist with possessions. The article also points out when psychiatrists should refer patients to an exorcist priest. The golden rule turns out to be to give the psychiatrist what belongs to psychiatrists, and to the exorcist priest what belongs to exorcists.
Combination of Topical Use of a Thrombin-Based Hemostatic Matrix and Tranexamic Acid does not have a Synergic Effect on Reducing Postoperative Blood Loss in Minimally Invasive Total Knee Arthroplasty. A Prospective Randomized Controlled Study
Authors:   Department of Orthopaedic Surgery. Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Taiwan, SH Yen , PC Lin ,   Department of Orthopaedic Surgery. Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Taiwan, YD Lu ,   Department of Orthopaedic Surgery. Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Taiwan, JW Wang ,   Department of Orthopaedic Surgery. Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Taiwan
Published: August 2021

Background: There is limited information regarding the blood-conservation effect of combined topical Tranexamic Acid (TXA) and Thrombin-Based Hemostatic Matrix (TBHM) in Total Knee Arthroplasty (TKA). This study is to evaluate whether there is synergic effect of combined use of TXA and TBHM to reduce blood loss during TKA. Materials and Methods: Sixty-nine patients (69 knees) who underwent primary TKA were randomly assigned into a TXA group (n=34), who received intra-articular administration of 3g of TXA in 60mL saline, and a TXA + TBHM group (n=35), who received intra-articular TBHM and TXA (3g) in 60mL saline after TKA. The primary outcomes were Total Blood Loss (TBL) and postoperative Hemoglobin (Hb) level. Secondary outcomes included the transfusion rate and the incidence of Venous Thromboembolism (VTE). Results: The mean TBL in the TXA + TBHM group was 678 ± 203 mL , which was similar to that in the TXA only group at 733 ± 217 mL (p=0.276). There were no differences in the postoperative Hb level between the two groups. The transfusion rate was similar in the TXA + TBHM group and the TXA only group (2.9% versus 0%, p=0.242). No patients in either group developed VTE within 3 months. Conclusions: Our prospective randomized controlled study did not show a synergic blood-conservation effect of combined use of topical TBHM and TXA in patients undergoing TKA. Further investigation with a larger sample size may be required.
Differentiating Disobedients
Authors: Lim Chong-Ming
Published: August 2021

Conscientious disobedients often face the demand to differentiate themselves from criminals whose law-breaking actions are not undergirded by conscientious convictions. In public and philosophical discourse, conscientious disobedients are often criticised on the basis that their actions render them no different from criminals. I provide a qualified defence of disobedients in this essay. I argue that the differentiation demand can be satisfied even by disobedients who engage in what are typically regarded as radical acts of disobedience. In practical terms, this means that even disobedients who engage in actions such as arson, looting, rioting, vandalism or vigilantism can also successfully differentiate themselves from criminals.
Simple models to include influenza vaccination history when evaluating the effect of influenza vaccination
Authors: Martínez-Baz Iván , Navascués Ana , Casado Itziar , Aguinaga Aitziber , Ezpeleta Carmen , Castilla Jesús
Published: August 2021

Background

Most reports of influenza vaccine effectiveness consider current-season vaccination only.

Aim

We evaluated a method to estimate the effect of influenza vaccinations (EIV) considering vaccination history.

Methods

We used a test-negative design with well-documented vaccination history to evaluate the average EIV over eight influenza seasons (2011/12–2018/19; n = 10,356). Modifying effect was considered as difference in effects of vaccination in current and previous seasons and current-season vaccination only. We also explored differences between current-season estimates excluding from the reference category people vaccinated in any of the five previous seasons and estimates without this exclusion or only for one or three previous seasons.

Results

The EIV was 50%, 45% and 38% in people vaccinated in the current season who had previously received none, one to two and three to five doses, respectively, and it was 30% and 43% for one to two and three to five prior doses only. Vaccination in at least three previous seasons reduced the effect of current-season vaccination by 12 percentage points overall, 31 among outpatients, 22 in 9–65 year-olds, and 23 against influenza B. Including people vaccinated in previous seasons only in the unvaccinated category underestimated EIV by 9 percentage points on average (31% vs 40%). Estimates considering vaccination of three or five previous seasons were similar.

Conclusions

Vaccine effectiveness studies should consider influenza vaccination in previous seasons, as it can retain effect and is often an effect modifier. Vaccination status in three categories (current season, previous seasons only, unvaccinated) reflects the whole EIV.
Bilateral acute renal infarction treated by endovascular therapy: A case report and literature review
Authors:   1Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan,   2Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan,   3Department of Internal Medicine, Faculty of Medicine, School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Published: August 2021

Renal infarction is a rare emergency and the estimated incidence is extremely low according to the literature. In addition, simultaneous bilateral renal infarction was only about 20% in these rare cases. Herein we reported a case of acute renal failure related to bilateral renal infarction and successfully treated by endovascular therapy including angioplasty and catheter-directed thrombolysis. His renal function also significantly improved after the intervention. This rare case reminds physician that early endovascular therapy might improve renal function and result in better renal outcome for patients with simultaneous bilateral renal infarction.
Türkiye’de Bilimsel Okuryazarlık Alanında Yapılan Araştırmaların İçerik Analizi
Authors: ARDUÇ Mehmet Akif , KAHRAMAN Sibel
Published: August 2021

Amaç: Bu çalışmanın amacı 2010-2019 yılları arasında bilimsel okuryazarlık alanında Türkiye’ de yayımlanan çalışmaların içerik analizini yapmak ve bu çalışmaların eğilimlerini belirlemektir. Bu amaçla bilimsel okuryazarlık kavramı ile ilgili araştırmalar türü, yılı, amacı, örneklem düzeyi, örneklem sayısı, örneklem seçim şekli, yöntem ve deseni, veri toplama araçları, verilerin analiz şekli, tezlerin yayımlandığı üniversiteler ve makalelerin yayımlandığı dergiler açısından değerlendirilmiştir.

Yöntem: Çalışma yöntemi nitel araştırma yöntem türlerinden doküman incelemesidir. Araştırmada toplam 55 yüksek lisans, 7 doktora tezi ve 28 makale analiz edilmiştir. Elde edilen çalışmalar yayın sınıflama formundan yararlanarak sınıflandırılmıştır.

Bulgular: Çalışma sonucunda bilimsel okuryazarlık çalışmalarının en fazla yüksek lisans tezi olduğu, en fazla çalışmanın 2019 yılında yayımlandığı, örneklem olarak daha çok ortaokul-lise öğrencileri üzerinde çalışıldığı ve örneklem şekli olarak daha çok kolay ulaşılabilir örneklem seçildiği görülmüştür. İncelenen çalışmalarda daha çok nicel araştırma yöntemleri kullanılmıştır. Çalışmalar amaçlarına göre sınıflandırıldığında, çoğunlukla bilimsel okuryazarlık ile çeşitli değişkenler arasındaki ilişkilerin belirlendiği çalışmalar tespit edilmiştir. Bilimsel okuryazarlık alanında Marmara Üniversitesi’nde diğer üniversitelere göre daha fazla tez çalışmasının yapıldığı sonucu elde edilmiştir.

Sonuçlar ve Öneriler: Çalışmanın sonuçlarına göre, araştırmacıların tezlerden yayın üretmeye teşvik edilmesi önerilebilir.Kolay örnekleme yöntemleri yerine tabakalı örnekleme, rastgele örnekleme, sistematik örnekleme vb. kullanılmalıdır;ortaokul-lise grupları dışındaki gruplarla da çalışılmalıdır.
Self-health Monitoring and Reporting System for COVID-19 Patients Using CAN Data Logger
Authors: Deshpande Uttam U. , Hulajatti Pooja , Suryavanshi Shraddha , Balgi Vrunda
Published: August 2021

In the evolving situation of highly infectious coronavirus, the number of confirmed cases in India has largely increased, which has resulted in a shortage of health care resources. Thus, the Ministry of Health and Family Welfare- Government of India issued guidelines for the ‘Home isolation of COVID-19 positive patients’ methodology for asymptomatic patients or with mild symptoms. During home isolation, the patients are required to monitor and record the pulse rate, body temperature, and oxygen saturation three times a day. This paper proposes a system that can request data from the required sensor to measure the pulse rate, body temperature, or oxygen saturation. The requested data is sensed by the respective sensor placed near the patients’ body and sent to the CAN data logger over the CAN bus. The CAN data logger live streams the sensor values and stores the same to an excel sheet along with details like the patient’s name, patient’s age, and date. The physicians can then access this information.
Changes in profibrotic activity in cardiovascular diseases
Authors: Ivaneta D Yoncheva  , Denislav E Biserov  , Maria N Negreva MD
Published: August 2021

The myocardium consists of several types of cells: cardiomyocytes, cardiac fibroblasts, endothelial cells and smooth muscle cells. Fibroblasts are cells of mesenchymal origin and are present in all tissues in the body. Cardiac damage can activate available CFBs, provoke transformation of endothelial or epithelial cells into fibroblasts, or induce the production of CFBs from hematopoietic cells and bone marrow. The change in ECM is a key point in the remodeling of the heart in response to the disease process. Disruption of the reticular structure of the ECM alters the connection between myocardial cells and blood vessels, thereby disrupting the structure and function of the heart muscle. Type I and III collagen fibrils are the predominant part of the ECM of the heart. They are synthesized as procollagen, which is converted to a mature collagen molecule. Procollagen type I propeptide (PICP), amino-terminal propeptide type I procollagen (PINP) and N terminal type III collagen peptide (PIIINP) are released in proportional amounts in the synthesis of collagen types I and III and can be used as serum markers for these processes. On the other hand the differentiation from CFBs to myoFB is supported by the transforming growth factor beta (TGF-β), connective tissue growth factor (CTGF), a number of cytokines in the ECM and others. The scientific community is faced with the question of which biomarkers to use to identify the early stages of development of cardiac fibrosis, as well as how to assess the degree of progression of this pathological process.
Generation of general system parameters for Rainbow electronic signature scheme for 384 and 512 security bits
Authors: Yesina M.V. , Kandiy S.O. , Ostryanska E.V. , Gorbenko I.D.
Published: August 2021

Today, there is rapid progress in the creation of quantum computers to solve various computational problems and for different purposes. At the same time, special efforts are made to create such a quantum computer that can solve the problems of cryptanalysis of existing cryptosystems:  asymmetric ciphers, key encapsulation protocols, electronic signatures, etc. Prevention of such threats can be achieved by developing cryptographic systems that will be protected against both quantum and classical attacks, and be able to interact with existing protocols and communication networks. There is also a significant need for protection against attacks by side channels. Currently, significant efforts of cryptologists are focused on the NIST PQC open competition. The main idea of the NIST PQC competition is to define mathematical methods based on which standards for asymmetric cryptotransformations, primarily electronic signatures, as well as asymmetric ciphers and key encapsulation protocols can be developed. Three electronic signature schemes – Crystals-Dilithium, Falcon and Rainbow become the finalists of the third stage of the NIST PQC competition according to the results of the second stage. The first two are based on the mathematics of algebraic lattices, and Rainbow is based on multivariate transformations. Currently, a comprehensive analysis of the finalists is an important task for the entire global crypto community. The vast majority of schemes that have become finalists or alternative algorithms are based on problems in the theory of algebraic lattices. Special attention was also paid to the Rainbow electronic signature scheme based on multivariate transformations. The purpose of this work consists in a preliminary analysis of existing attacks on promising electronic signature Rainbow, definition of requirements to the system-wide parameters to ensure cryptographic stability of at least 512 bits against classical and 256 bits against quantum cryptanalysis, as well as development and practical implementation of Rainbow algorithms for generating system-wide parameters for 512 bits against classical and 256 bits against quantum cryptanalysis.
Some results of development of cryptographic transformations schemes using non-abelian groups
Authors: Kotukh E.V. , Severinov O.V. , Vlasov A.V. , Tenytska A.O. , Zarudna E.O.
Published: August 2021

Implementation of a successful attack on classical public key cryptosystems becomes more and more real with the advent of practical results in the implementation of Shor's and Grover's algorithms on quantum computers. Modern results in tackling the problem of building a quantum computer of sufficiently power justify the need to revise the existing approaches and determine the most effective in terms of solving problems of post-quantum cryptography. One of these promising research priorities is the study of the cryptosystems based on non-abelian groups.

The problems of conjugacy search, membership search, and others are difficult to solve in the theory of non-abelian groups and are the basis for building provably secure public key cryptosystems. This paper gives an overview of the most frequently discussed algorithms using non-abelian groups: matrix groups braid groups, semi direct products, and algebraic erasers (AE). The analysis of the construction of encryption and decryption schemes, key establishment mechanisms is given. Many non-abelian group-based key establishment protocols are associated with the Diffie – Hellman (DH) protocol. The paper analyzes the properties of non-abelian group public key encryption schemes. Various cryptographic primitives using non-commutative groups as a basis for post-quantum schemes are considered.
Listening to NFC at higher harmonic frequencies
Authors: Kryzhanovskyi V.G. , Serhiienko S.P. , Chernov D.V. , Kryzhanovsky V.V.
Published: August 2021

The widespread use of the NFC technology (Near Field Communication) arouses interest to various security aspects. There are known examples of information exchange with card at a distance greater than standard 5-10 cm. It is also interesting to use signals of higher harmonics, which potentially may be radiated in the form of electromagnetic waves, rather than exists as a magnetic field of scattering. In this work, the radiation of third harmonic by card of standard ISO 14443-3А with the fundamental frequency 13.56 MHZ for various excitation modes using the RFID-RC522 reader, smartphone Sony Xperia Z5 Premium, and continuous 10% amplitude modulated 13.56 MHz signal from generator with the subcarrier of imitated smart card response 847.5 kHz was investigated. The card response at third harmonic was simulated in circuit analysis software. Both simulation and experiment proved, that the third harmonic with its side frequencies 40,68 ± 0,8475 MHz have the highest level after the fundamental. To receive the third harmonic signal, the resonant loop antenna in the form of ring vibrator loaded on capacitor was used. This allows the sizes of the received system to be reduced, but the problem of complex field structure in the near-field zone remains. Due to narrow bandwidth of the receiver antenna, the registration of card response signal was complicated. The experiments with three methods of signal generation proved, that third-harmonic signal is registered at the distance more than 1.5m, which may pose a threat for contactless smart-cards transactions security. At the same time, the influence of high level of noise at such a distance may cause difficulties to decode the short-duration signals, which requires further study.
Theoretical Substantiation of the Use of Sildenafil in the Treatment of Chronic Prostatitis
Authors: Gurzhenko Yurii , Spyrydonenko Volodymyr
Published: August 2021

Every year, the number of patients with chronic prostatitis (CP) in the world is increasing and improving the effectiveness of treatment of this pathology is becoming a priority topic in modern urology. One of the complications of CP is sexual dysfunction, primarily premature ejaculation, as well as erectile dysfunction (ED). Treatment of CP and its sexual complications is an individual and complex complication. It is undeniable that sildenafil citrate plays an important role in the treatment of ED as a complication of CP.
The hypothetical mechanism of the effectiveness of PDE-5 in CP is mediated by the relaxation of the smooth muscles of the ducts of the software, the effect of increasing the drainage of the components that are formed due to reflux in the interstitial tissue. The above phenomenon can suppress inflammation and cause a reduction in prostatic symptoms. Increased activity of NO-synthetase and PDE-5 in the tissues of PO promotes the formation of muscle relaxant effects, drainage of the acinus, reduced activity of the autonomic nervous system and activation of vascular circulation in the PVC and structures of the lower urinary tract.
Current scientific evidence indicates that PDE-5 inhibitors can improve lower urinary tract symptoms by relaxing bladder smooth muscle fibers and PO, by signaling NO / cGMPc, or by improving RhoA / Rho kinase. Some results suggest that in addition to the effects of reducing the hyperactivity of the autonomic nervous system, dilation of cavernous vessels and antiproliferative effect, PDE-5 have a direct anti-inflammatory effect, increasing the level of cGMP. The accumulation of the latter can inhibit inflammation and can be a potential mechanism for preventing the development of diseases in which inflammation plays a central role.
Given that inflammation is a major factor in the progression of CP, sildenafil citrate is able to restore PO function because they act as potent anti-inflammatory drugs.
Thus, PDE-5 inhibitors can not only mediate smooth muscle relaxation, but can also directly reduce inflammation in the software by increasing cGMP levels.
Based on theoretical data on the positive effect of sildenafil on the erectile component and symptoms of the lower urinary tract in persons with CP with complications such as ED, it can be considered that the inclusion of sildenafil citrate in sequential standard therapy for CP reduces indicators of erectile function. The appointment of sildenafil citrate in patients with complications of CP in the form of ED improves the quality of erections in patients, and also has a positive effect on various other indicators of male sexual function (enhances orgasm, increases the duration of sexual intercourse).
Morphological Changes of the Ureter in Patients with Ureterolithiasis Depending on the Duration of Clinical Manifestations
Authors: Vozianov Oleksandr
Published: August 2021

Urolithiasis (URL) is a common urological disease that often appears in the population, has a high recurrent rate and a significant impact on the social status of the population. Almost half of patients with URL disease are people with ureteric stones, 95% of which have secondary genesis. The main methods of treatment of such patients are extracorporeal shock-wave lithotripsy (ESWL) and ureterolithotripsy (URS). It is important in these cases to determine morphological changes (inflammation, edema, sclerosis, necrosis, etc.) that appear in the ureter in the placement of the stone and may reduce the effectiveness of minimally invasive treatment or/and removal of fragments during URS.
The objective: studying morphological changes of the ureter wall in patients with ureterolithiasis in the zone of the calculus in dependence of the duration of clinical manifestations.
Materials and methods. We have studied histological changes of the ureter wall in the location of the stone in patients with ureterolithiasis. We explored the ureter wall in patients depending on duration of typical manifestations of ureterolithiasis, which were 7-en days long, 30 days, and more than 2 months.
Results. If the stone in the ureter is up to 7 days, it does not cause significant microscopic changes of the ureter wall. If the stone been in the ureter during 1 month, more significant morphological changes are determined with desquamation of the urothelium, edema and inflammatory changes in the submucosal membrane. In case of the duration of the calculi in the ureter is more than 2 months, we noted the exfoliation of the urothelium with the denudation of the basement membrane. In the submucosal layer there is an edema, diffuse disorganization of connective tissue fibers, fragments of growth of granulation tissue and dense connective tissue in the form of separate layers.
Conclusion. With increasing duration of the disease in the wall of the ureter increases the manifestations of inflammatory, sclerotic and necrotic changes. Such changes have a direct impact on the quality of visualization of the calculus during endoscopic interventions, the rate of fragmentation and extraction (elimination) of fragments, as a consequence, increase the overall duration of the operation and the risk of intra- and postoperative complications.