bluuebunny/crossref_metadata_2025 huggingface dataset:
Treatment Combining Focused Ultrasound with Gastrodin Alleviates Memory Deficit and Neuropathology in an Alzheimer’s Disease-Like Experimental Mouse Model
Authors: Luo Kaixuan , Wang Yuhong , Chen Wen-Shiang , Feng Xiangjun , Liao Yehui , Chen Shaochun , Liu Yao , Liao Chengde , Chen Moxian , Ao Lijuan
Published: January 2022

Alzheimer’s disease (AD) is the most common type of dementia but lacks effective treatment at present. Gastrodin (GAS) is a phenolic glycoside extracted from the traditional Chinese herb—Gastrodia elata—and has been reported as a potential therapeutic agent for AD. However, its efficiency is reduced for AD patients due to its limited BBB permeability. Studies have demonstrated the feasibility of opening the blood-brain barrier (BBB) via focused ultrasound (FUS) to overcome the obstacles preventing medicines from blood flow into the brain tissue. We explored the therapeutic potential of FUS-mediated BBB opening combined with GAS in an AD-like mouse model induced by unilateral intracerebroventricular (ICV) injection of Aβ1-42. Mice were divided into 5 groups: control, untreated, GAS, FUS and FUS+GAS. Combined treatment (FUS+GAS) rather than single intervention (GAS or FUS) alleviated memory deficit and neuropathology of AD-like mice. The time that mice spent in the novel arm was prolonged in the Y-maze test after 15-day intervention, and the waste-cleaning effect was remarkably increased. Contents of Aβ, tau, and P-tau in the observed (also the targeted) hippocampus were reduced. BDNF, synaptophysin (SYN), and PSD-95 were upregulated in the combined group. Overall, our results demonstrate that FUS-mediated BBB opening combined with GAS injection exerts the potential to alleviate memory deficit and neuropathology in the AD-like experimental mouse model, which may be a novel strategy for AD treatment.
Study of Various Epoxy-Based Surface Coating Techniques for Anticorrosion Properties
Authors: Ramakrishnan T , Raja Karthikeyan K , Tamilselvan V , Sivakumar S , Gangodkar Durgaprasad , Radha H R , Narain Singh Anoop , Asrat Waji Yosef
Published: January 2022

Polyepoxides are a kind of chemical polymerization that is widely employed in several industrial purposes. Due to their macromolecular structure, polyepoxides offer superior superficial treatment and antierosion activity compared to basic organic corrosion inhibitors. During metal-inhibitor interactions, the polyepoxides outlying glacial efficient clusters operate as adsorption centers. Numerous polyepoxides have been employed as anticorrosive coating materials in both pure and cured forms, most notably for ferrite in acidic and NaOH solutions. The majority of polyepoxides operate as inhibitors of interface and mixed-type corrosion. Numerous computer models have been done to illustrate the anticorrosive properties of polyepoxides on metallic shells and their adsorption behavior. However, because the majority of polyepoxides have low solubility, they are best used as anticorrosive coating materials. Numerous polyepoxides-based coatings have been created and effectively applied on ferrite and aluminum in salt-water solution according to a review of the literature. Natural and synthetic additives can be used to further enhance the anticorrosive properties of polyepoxides coatings. This review article compiles published findings on the anticorrosive properties of pure and cured polyepoxides for a variety of metals and alloys in a variety of electrolytes.
Intelligent Diagnosis Method for New Diseases Based on Fuzzy SVM Incremental Learning
Authors: Song-men Shi
Published: January 2022

The diagnosis of new diseases is a challenging problem. In the early stage of the emergence of new diseases, there are few case samples; this may lead to the low accuracy of intelligent diagnosis. Because of the advantages of support vector machine (SVM) in dealing with small sample problems, it is selected for the intelligent diagnosis method. The standard SVM diagnosis model updating needs to retrain all samples. It costs huge storage and calculation costs and is difficult to adapt to the changing reality. In order to solve this problem, this paper proposes a new disease diagnosis method based on Fuzzy SVM incremental learning. According to SVM theory, the support vector set and boundary sample set related to the SVM diagnosis model are extracted. Only these sample sets are considered in incremental learning to ensure the accuracy and reduce the cost of calculation and storage. To reduce the impact of noise points caused by the reduction of training samples, FSVM is used to update the diagnosis model, and the generalization is improved. The simulation results on the banana dataset show that the proposed method can improve the classification accuracy from 86.4% to 90.4%. Finally, the method is applied in COVID-19’s diagnostic. The diagnostic accuracy reaches 98.2% as the traditional SVM only gets 84%. With the increase of the number of case samples, the model is updated. When the training samples increase to 400, the number of samples participating in training is only 77; the amount of calculation of the updated model is small.
Common Fixed Point Theorems for Weakly Contractions in Rectangular
b
-Metric Spaces with Supportive Applications
Authors: Guan Hongyan , Li Jianju , Hao Yan
Published: January 2022

In this manuscript, two new classes of generalized weakly contractions are introduced and common fixed point results concerning the new contractions are proved in the context of rectangular

b

-metric spaces. Also, some examples are included to present the validity of our theorems. As an application, we provide the existence and uniqueness of solution of an integral equation.
The Association of Trefoil Factors with Gastric Cancer and Premalignant Lesions: A Cross-Sectional Population-Based Cohort Study
Authors: Zan Xiangyi , Chen Zhaofeng , Guo Qinghong , Wang Yuping , Zhang Zhiyi , Ji Rui , Zheng Ya , Zhang Jinhua , Wu Zhengqi , Li Min , Wang Xiang , Ye Yuwei , Li Xiaohua , An Feng , Xu Chuanggui , Lu Linzhi , Fan Ping , Zhang Jun , Guan Quanlin , Li Qiang , Liu Min , Ren Qian , Hu Xiaobin , Lu Hong , Wang Yuling , Zhang Hongling , Zhao Yue , Gou Xi , Shu Xiaochuang , Wang Jun , Hu Zenan , Liu Rong , Yuan Hao , Liu Jiankang , Qiao Liang , Zhou Yongning
Published: January 2022

Background:

A lack of research on the association of trefoil factors (TFF) with gastric cancer and premalignant lesions (PML) in the general population is an important obstacle to the application of TFFs for gastric cancer screening. We aimed to analyze the association of TFFs with gastric cancer and PMLs in a general population.

Methods:

We evaluated 3,986 adults residing in Wuwei, China. We collected baseline characteristics and gastric cancer risk factors, including TFFs, endoscopic diagnosis, and pathologic information. Three logistic regression models were generated to analyze the association between TFFs and gastric cancer, as well as PMLs. Adjusted odds ratio (OR) and 95% confidence intervals (95% CI) were calculated to determine the strength of association.

Results:

Compared with pepsinogen (PG) and anti–Helicobacter pylori immunoglobulin G antibody (Hp-IgG), TFFs had significant association with gastric cancer and PMLs after adjusting for biomarkers and risk factors (P < 0.05). The ORs (95% CI) for TFF1 (1.67; 1.27–2.20), TFF2 (2.66; 2.01–3.51), and TFF3 (1.32; 1.00–1.74) were larger than the ORs for PGI (0.79; 0.61–1.03), PGI/II (1.00; 0.76–1.31), and Hp-IgG (0.99; 0.73–1.35) in the gastric cancer group. In the intestinal metaplasia (IM) group, not only the TFF3 serum level was the highest, but also the OR (1.92; 1.64–2.25) was the highest.

Conclusions:

TFFs were associated with risk of gastric cancer and PMLs.

Impact:

Serum TFFs can improve the screening of high-risk populations for gastric cancer.
Family History and Risk of Bladder Cancer: An Analysis Accounting for First- and Second-degree Relatives
Authors: Yu Evan Yi-Wen , Stern Mariana C. , Jiang Xuejuan , Tang Li , van den Brandt Piet A. , Lu Chih-Ming , Karagas Margaret R. , La Vecchia Carlo , Bosetti Cristina , Polesel Jerry , Golka Klaus , Zhang Zuo-Feng , Villeneuve Paul , Zeegers Maurice P. , Wesselius Anke
Published: January 2022

Although evidence suggests that a positive family history of bladder cancer in first-degree relatives is an important risk factor for bladder cancer occurrence, results remain unclear. The influence of family history of nonbladder cancers and more distant relatives on bladder cancer risk is inconsistent. This research, therefore, aims to increase the understanding of the association between family history and bladder cancer risk based on worldwide case–control studies. In total 4,327 cases and 8,948 non-cases were included. Pooled ORs, with corresponding 95% confidence intervals (CI), were obtained using multilevel logistic regression models, adjusted by age, sex, ethnicity, smoking status, and smoking pack-years. The results show bladder cancer risk increased by having a first- or second-degree relative affected with bladder cancer (OR, 2.72; 95% CI, 1.55–4.77 and OR, 1.71; 95% CI, 1.22–2.40, respectively), and nonurologic cancers (OR, 1.61; 95% CI, 1.19–2.18). Moreover, bladder cancer risk increased by number of cancers affected first-degree relatives (for 1 and >1 first-degree relatives: OR, 1.42; 95% CI, 1.02–2.04; OR, 2.67; 95% CI, 1.84–3.86, respectively). Our findings highlight an increased bladder cancer risk for a positive bladder cancer family history in first- and second-degree relatives, and indicate a possible greater effect for an increment of numbers of affected relatives.

Prevention Relevance:

This study found a positive association between family history and bladder cancer in first- and second-degree relatives, with an added effect attributed to smoking. Given the detriments of bladder cancer, at-risk individuals should receive family history screening and tobacco cessation and avoidance counseling.
The Challenge of Melanoma Chemoprevention
Authors: Elmets Craig A. , Slominski Andrzej , Athar Mohammad
Published: January 2022

Melanoma is a treatment-resistant cancer of melanocytes. There is a serious unmet need for chemopreventive agents that can inhibit their evolution from preexisting dysplastic nevi. Low-dose aspirin and NSAIDs are potential chemopreventive candidates because they inhibit the enzyme COX-2 which has a number of procarcinogenic effects. Unfortunately, the clinical trial reported by Okwundu and colleagues in this issue of Cancer Prevention Research did not show an effect of aspirin on biomarkers associated with progression of premalignant dysplastic nevi to melanomas. Further clinical trials with other aspirin or NSAID biomarkers or clinical trials with other potential chemopreventive agents offer hope to those who are at increased risk for melanomas.

See related article, p. 129
Environmental Enrichment Facilitates Anxiety in Conflict-Based Tests but Inhibits Predator Threat-Induced Defensive Behaviour in Male Mice
Authors: dos Anjos-Garcia Tayllon , Kanashiro Alexandre , de Campos Alline Cristina , Coimbra Norberto Cysne
Published: January 2022

Introduction: Environmental enrichment (EE) is a useful and sophisticated tool that improves rodents’ well-being by stimulating social behaviour and cognitive, motor, and sensory functions. Exposure to EE induces neuroplasticity in different brain areas, including the limbic system, which has been implicated in the control of anxiety and fear. However, the effects of EE on ethologically relevant naturalistic behaviours, such as those displayed by prey in the presence of predators, remain largely unexplored. Material and Methods: In the present study, we investigated anxiety- and panic attack-like behaviours in a predator (cat)-prey confrontation paradigm and compared them with those in classical assays, such as the elevated plus-maze (EPM), marble-burying, and open field tests (OFTs), using C57BL/6J male mice housed in enriched or standard environments for 6 weeks. Results: We observed that EE exposure caused enhancement of the levels of anxiety-like behaviours in the EPM and OFTs, increasing risk assessment (an anxiety-related response), and decreasing escape (a panic attack-like response) behaviours during exposure to the predator versus prey confrontation paradigm. Conclusion: Taken together, our findings suggest that enriched external environments can modify the processing of fear- and anxiety-related stimuli in dangerous situations, changing the decision-making defensive strategy.
Erythrodermische CD4-/CD8-doppelt-negative Mycosis fungoides: ein Fallbericht
Authors: Alnasser Monira Abdullah , AlKhawajah Nour Marwan , Al-Qadri Nada , Shadid Asem Mustafa , Alsaif  Fahad M.
Published: January 2022

Unter dem Begriff der kutanen T-Zell-Lymphome (CTCL) wird eine Gruppe lymphoproliferativer Erkrankungen zusammengefasst, die durch Lokalisation neoplastischer T-Lymphozyten in der Haut gekennzeichnet sind. Die Mycosis fungoides (MF) ist die häufigste Form von CTCL; sie macht ∼60 % aller primären kutanen Lymphome aus. Neben der klassischen Form der MF sind zahlreiche klinische und histopathologische Varianten beschrieben worden. Die malignen Lymphozyten bei MF sind meist positiv für CD3, CD4 und CD45RO und negativ für CD8. Ein ungewöhnlicheres immunhistochemisches Profil eines CD4-negativen und CD8-positiven reifen T-Zell-Phänotyps wird bei einer Minderheit der Patienten beschrieben; in bis zu 20 % der Fälle von MF im Frühstadium liegt ein CD8-positiver Phänotyp vor. Über einen für CD4 und CD8 doppelt-negativen MF-Phänotyp gibt es nur einige wenige Berichte in der Literatur. Wir stellen hier den Fall eines 60-jährigen Mannes mit MF mit CD4/CD8-doppelt-negativem Phänotyp vor.
The Spectrum of Genetic Variants Associated with the Development of Monogenic Obesity in Qatar
Authors: AbouHashem Nadien , Zaied Roan E. , Al-Shafai Kholoud , Nofal Mariam , Syed Najeeb , Al-Shafai Mashael
Published: January 2022

Introduction: Monogenic obesity (MO) is a rare genetic disease characterized by severe early-onset obesity in affected individuals. Previous genetic studies revealed 8 definitive genes for monogenic non-syndromic obesity; many were discovered in consanguineous populations. Here, we examined MO in the Qatari population, whose population is largely consanguineous (54%) and characterized by extensive obesity (45%). Methods: Whole genome sequencing data of Qatar Biobank samples from 250 subjects with obesity and 250 subjects with normal weight, obtained in association with the Qatar Genome Programme, were searched for genetic variants in the genes known to be associated with MO (i.e., LEP, LEPR, POMC, PCSK1, MC3R, MC4R, MRAP2, and ADCY3). The impact of the variants identified was investigated utilizing in silico tools for prediction in combination with protein visualization by PyMOL. Results: We identified potential MO variants in more than 5% of the cases in our cohort. We revealed 11 rare variants in 6 of the genes targeted, including two disease-causing variants in MC4R and MRAP2, all of which were heterozygous. Moreover, enrichment of a heterozygous ADCY3 variant (c.1658C>T; p.A553V) appeared to cause severe obesity in an autosomal dominant manner. Conclusion: These findings highlight the importance of implementing routine testing for genetic variants that predispose for MO in Qatar. Clearly, additional studies of this nature on populations not yet examined are required. At the same time, functional investigations, both in vitro and in vivo, are necessary in order to better understand the role of the variants identified in the pathogenesis of obesity.
Decision Support System in Scholarship Acceptance Selection Using The Vikor Method
Authors: Sari Venny Novita , Utami Feri Hari , Asnawati  , Yupianti  , Alinse Rizka Tri , Fredricka Jhoanne
Published: January 2022

This study aims to apply the vikor method in the selection of scholarship receipts at Bengkulu Dehasen University. Designing the process by describing how the VIKOR (Visekriterijumsko Kompromisno Rangeranje) method should be used based on criteria (indications, achievements, credits and living expenses) fulfilled by prospective scholarship recipients in accordance with the provisions of Dehasen Bengkulu University in selecting scholarship acceptance. Based on the results obtained it can be proven that the condition of Acceptable stability in decision making is fulfilled (Namely a smaller value than 1) and Intan P Can be proposed to be a compromise solution which is the best ranking of scholarship recipients ranking by this VIKOR (Visekriterijumsko Kompromisno Rangeranje) method.
Predictors Affecting the Level of Work Satisfaction in Relation to the Job Performance Among Secondary School Teachers in the Division of Zambales During SY 2020-2021
Authors: Villanueva Alma G. , Meer Thelma Q.
Published: January 2022

The research aimed to determine the Predictors Affecting the Level of Work Satisfaction in Relation to the Work Performance Among Secondary School Teachers in the Division of Zambales During SY 20120-2021. The descriptive research design were used with survey questionnaire as the data gathering.The study was limited on predictors affecting the level of work performance as to teaching hours, salary/remuneration, school officials/administrators, peer/colleagues, student factor, work environment and community supports predictors respectively. The respondents of the study were Secondary Teachers in the Division of Zambales.

The findings revealed that the teacher-respondent is a typical female in her early adulthood, married, Roman Catholic, Mathematics major, Teacher 1, BS degree with masteral units of education and had been teaching for almost a decade. The teacher-respondent agreed on the predictors affecting the level of work performance as to teaching hours, salary/remuneration, school officials/administrators, peer/colleagues, student factor, work environment factor and community support. The teachers were rated “Very Satisfactory” on their level of work performance. There was a significant difference on the assessment towards salary/remuneration when grouped according to civil status, religion and highest educational attainment; on school officials/administrators when grouped according to position/designation. There was significant difference on the assessment of the teacher-respondents towards predictors affecting the level of work satisfaction. There was no significant relationship between the work satisfaction predictors and the level of work performance as reflected in the IPCRF performance rating.
Development of a Better Solid Waste Management Program for Sustainable Development in a Residential Subdivision
Authors: Almaden Antoniette M.
Published: January 2022

Proper implementation of Solid Waste Management (SWM) is an essential part for the protection of the residents’ health, safety and environmental quality. SWM methods have been adapted by many residential subdivisions into a more practical and effective option to establish sustainability based on the reduce, reuse, and recycle principles. This study aims to contribute a solution to the challenging operation of solid waste management in Modena Mactan subdivision (1) to comprehensively describe the homeowner’s status classification and demographic characteristics, (2) to evaluate volume of waste produced and recycled waste revenue collected, (3) to recognize homeowner’s perception on the current waste management status, and (4) to showcase feasible approaches for sustainable waste management program. The study applied the descriptive research design and was carried out to 93 homeowners who went through the (house-to-house) paper-pencil-questionnaire survey. Results showed that the subdivision produced an average of 33 tons or 16.974 kilograms of solid waste per household per month, and generated an amount of 1,369 PHP or 27.41 USD revenue from the segregated recyclable waste collected from August 1-28, 2021. Moreover, about 87% of the respondents found convenient and sought to change in paperless system. Conclusively, it was revealed that 74% of the respondents found the recycling incentive scheme more inclusive as a feasible approach for waste management strategy to sustain the solid waste management program in Modena Mactan subdivision, Basak, Lapu-Lapu City, Cebu, Philippines.
The Learning Delivery Modalities in Catanduanes State University
Authors: Antonio Julius S.
Published: January 2022

The suspension of conduct of face-to-face learning has shifted the Catanduanes State University (CatSU) to adapt flexible blended learning in delivering instruction and learning experiences to its students. As directed by the Commission on Higher Education, universities and colleges in the Philippines should adapt flexible blended learning. With limited training on blended learning, the CatSU faculty members are prone to some limitations and drawbacks while implementing the adapted Learning Delivery Modalities (LDMs). An investigation on the implementation of LDMs in CatSU revealed that faculty members used blended learning that is a combination of online synchronous or asynchronous classes to offline modular distance learning. The platform used by the faculty members in conducting synchronous classes were Zoom and Google Meet. On the other hand, the platform used in conducting asynchronous sessions was Google Classroom. While the adapted flexible blended learning of CatSU faculty members include online learning, a few faculty members reported that they had trouble in contacting their students since either the students don’t own mobile phones, or they don’t have phone signals at home. Some faculty members considered having not provided with internet service at school as a minor problem. Possible solutions for the different problems encountered by the faculty members have been recommended in this study.
Factors Affecting Teachers' Performance in Public Elementary Schools in Schools Division of City of Meycauayan, Bulacan
Authors: Paz Rosalia M.
Published: January 2022

The major concern of this study was to determine the impact of factors affecting teachers' performance of public elementary teachers. The study used the descriptive- correlational method of research in which standardized instruments were the primary data gathering tool. The study respondents were 166 or 55.41 percent of public elementary teachers in cluster A of the Division of Meycauayan City. The results of the study revealed that for the level of contributing factors in teaching performance, much contribution overall rating was obtained in the following factors: (1) Person-related factor, (2) School-related factor, (3) Learner-related Factor and (4) Community-related factor. Meanwhile, on the level of teaching performance, it was revealed based on the result of the study that the following factors were accomplished in terms of (1) Content, Knowledge, and Pedagogy, (2) Learning Environment and Diversity of Learners, (3) Curriculum and Planning, (4) Assessment and Reporting and (5) Plus Factors. The study's findings indicated that the contributing factors in teaching performance such as person-related Factor, school-related Factor, learner-related Factor, and community-related factor correlated to the level of teachers' performance in terms of the five key result areas. The findings of the analysis revealed that the null hypothesis is rejected; hence, the contributing factors significantly impacted teachers' teaching performance.
A Comparative Case Study on the Challenges Encountered by Philippine Private and Public Educational Institutions with their Existing Management Information System
Authors: Zulueta Ma. Cristina E. , Buno Rona Mae V. , Cruz Aaron C. Dela , Sagun Angelita J. , Buenaventura Michaela DC San , Talidano Aileen S. , Cabrera Wendell C.
Published: January 2022

For the last two years, all Philippine educational institutions had to adapt flexible learning. All personnel and students underwent orientation and training to their institution’s Management Information System (MIS). These institutions are utilizing either MIS mandated by the Department of Education, subscribed to or created by the institution itself. Challenges and concerns have been noted on the use of these MIS worldwide. Hence, this study elucidated the experiences and challenges of admistrators, faculty and students with their existing MIS among public and private educational institutions in the Philippines. Using a qualitative comparative case study design, the researchers draw the experiences of the participants on their existing MIS. The findings of the study revealed three main themes on the experiences of the participants with their existing MIS: excellent way to systematize and organize, a work in progress and encompassing of all institutional services. On the resolution of concerns and challenges with their MIS, prevailing themes were: having an efficient and expert Information Technology (IT) team, continuous feedback and improvement, and unresolved due to poor internet connectivity. As to how these challenges affected their performance, themes clustered on: improved and more efficient, negatively affected output and efficiency, and unaffected. This study highlighted the importance of proper orientation and training of all personnel and students, for an effective MIS which must be managed by an expert IT team. Despite the challenges encountered, the use of the MIS led to the better performance of the participants’ duties and responsibilities.
Development of Virtual Laboratory Simulation: e-SCILAB on Waves for Grade 7 Science
Authors: Tongco John , Silvederio Wesley Clarke , Salanawon Pamela Joy , Mercado Justine
Published: January 2022

Virtual Laboratory Simulation (VLS) enhances student understanding, retention of concepts, and promotes active learning through direct visualization and manipulation of computer animations. This study aimed to develop a VLS with complementary manual for Grade 7 physics that can be utilized by the teachers to address the needs of the students in the new normal learning. The developed VLS is composed of a Teacher’s Instructional Manual and Student’s Learning Manual. The study used Research and Development approach with the ADD (Analysis, Design, and Development) model as the instructional method. These allows the researchers to analyze the need of VLS, identify the design of VLS, and develop the VLS. The VLS was evaluated based on the content quality with a mean of 4.68, technical quality with 4.65, and instructional quality with 4.57. The results for the complementary activity manual in terms of the content quality is a mean of 4.62, the technical quality with 4.54, and the instructional quality with 4.55. The result showed that the developed VLS together with the complementary activity manual satisfied the quality components and attained the intended standards. It is recommended that evaluation of the effectiveness of VLS through pilot tests in public and private schools.
Learning of Science among Students at Risk of Dropping out (Sardo) Using Technology-Driven Intervention
Authors: Pañares Mylene Amor Sayson , Ybanez Reggie Sayson
Published: January 2022

The purpose of this study was to determine the efficacy of Technology-Driven Intervention in improving science learning among Alegria National High School students at risk of dropping out. This study focused on two groups of twenty (20) Grade 8 Students at Risk of Dropping Out. Ten SARDOs served as the control group and received work text intervention, while the other ten SARDOs received technology-driven intervention. Both groups performed POORLY in Science knowledge at the start of the experiment, according to the results. T-test results also revealed that both the work text intervention and the technology-driven intervention were effective in the learning of SARDOs. The mean gain scores of SARDOs that used technology-driven intervention, on the other hand, were significantly higher. The study concludes that a technology-based intervention is more effective than a traditional intervention for students at risk of dropping out.
Feasibility of Offering Bachelor of Technical Vocational Teacher Educa-tion (BTVTEd) Major in Computer Hardware Servicing in Sorsogon State University – Bulan Campus
Authors: Medalla Jopet Vincent B. , Dipad Mark Anthony D. , Bongalosa Corazon G.
Published: January 2022

Based on CHEd Memorandum Order No. 79, series of 2017, the Bachelor of Technical Vocational Teacher Education (BTVTEd) Major in Computer Hardware Servicing program is designed to enhance the knowledge, desirable values and skills of computer service technicians in accordance with industry standards. This mixed design research sought to determine the feasibility of offering this program in Sorsogon State University - Bulan Campus (SorSU-BC). It was found that the offering of the program is highly necessary and can expect a moderate sufficiency of enrolees. The program will also provide significant benefits to the different domains of the society such as the government, the community, the business industries and the students. The offering of the program is also highly sustainable in terms of enrolment, faculty, competition and facilities. It is also consistent with the vision and mission of the university and adheres to the pertinent legal foundations. Generally, faculty requirements are complied with but there is a need to hire faculty members with master’s degree in technology education or its equivalent. The laboratories and physical facilities required for the offering of the program are already available considering the existence of the IT-education and teacher-education programs. Therefore, the offering of BTVTEd major in Computer Hardware Servicing is found to be feasible. It is recommended for SorSU Bulan Campus to craft a program curriculum for BTVTEd Computer Hardware Servicing so that it can be offered in the university with the approval of the Commission on Higher Education.
Strengthening the Child’s Protection Program in the Philippines
Authors: Mobo Froilan D.
Published: January 2022

The impact of the COVID-19 Pandemic greatly affects not only the economy but also the society because the majority of the Filipino were unemployed which makes their lives and situations more devastated. There are many reports in the Philippines that violence on child at home – predominantly those children already living in vicious or dysfunctional family situations, (Ramirez, 2020).  It was also reported that during the lockdown period in March 2020, The Philippine justice agencies and child protection shareholders rescued at least 136 victims, seized 30 suspects, and found 18 convictions. The Local Government Unit with the collaborations of the Barangay must strengthen the child protection program amidst the COVID-19 Pandemic this is to reduce child victims from violence to achieve the 17 sustainability and development of the United Nations.
Course Crediting and Academic Evaluation System of The College of Communication and Information Technology
Authors: Sepillo Geoffrey S.
Published: January 2022

The study aimed to develop a Course Crediting and Academic Evaluation System of the College of Communication and Information Technology (CCIT) in President Ramon Magsaysay State University – Iba Campus to offer an online system to ease the procedures of crediting and evaluation of the student academic records. Descriptive research design and descriptive statistics were utilized in this study. The dean, program chairpersons, and students of Bachelor of Science in Computer Science, Bachelor of Science in Computer Engineering and Bachelor of Science in Computer Engineering are the respondents of the study. The findings revealed that the respondents evaluated the software quality of the system using the International Organization for Standardization and the International Electrotechnical Commission (ISO/IEC): 25010:2011 as excellent. The respondents evaluated as strongly recommended on the degree of recommendation of the acquisition and implementation of the system. The Course Crediting and Academic Evaluation System is recommended to implement to improve the present procedures. Training to the end-users is advised to be conducted to know how to use the system. The maintenance and continuous enhancement of the system to adapt to the changing trends in information technology.
The Effect of Budget Participation and Organizational Commitment on Budgetary Slack
Authors: Agustina Duwi , Suhaidar
Published: January 2022

This study aims to measure the effect of employee participation in budgeting and organizational commitment to budgetary slack in Bangka Belitung Islands Provincial Government Agencies, in particular the Public Works and Spatial Planning Office of the Bangka Belitung Islands Province. The analytical method used for testing the variables in this study uses PLS (Partial Least Square) using Smart PLS.3 software. The sample used in this study were 50 employees at the Department of Public Works and Spatial Planning of the Bangka Belitung Islands Province. The first hypothesis in this study is accepted, namely budget participation has a positive effect on budgetary slack, but the second hypothesis in this study is rejected, namely organizational commitment has a negative effect on budgetary slack. This identifies that the participation of many parties in a company or scope of work to jointly exchange information in determining and compiling a budget to achieve an organizational goal.
Appointment of Leader Position: Study on the Regional Government of West Nusa Tenggara
Authors: Anwar Raihan , Luddin Muchlis Rantoni , Wibowo Agus
Published: January 2022

This study aims to develop a model for leadership appointment positions in the Regional Government of Nusa Tenggara Barat. Using Yin multi case study method, data collection was carried out through observation, tracing and document analysis as well as in-depth interviews with informants consisting of two clusters (K-I and K-II). This research found that competence supports meritocracy, because the higher the competence, the better the meritocracy value. Meritocracy get the most dominant element, and political intervention has a negative role on employees and hinders the implementation of meritocracy, however, political functions in policy formulation and political control over the bureaucracy are needed. Local wisdom strengthens values ​​of morality and integrity so as to fortify the unfair competition between civil servants and the discretion of regional heads. Talent management as urgent factor considering that more than half of the human resources are in a critical age. The study recommends developing a model for leadership appointment position with local wisdom and talent management elements that reinforce competence and meritocracy and inhibit political discretion towards superior performing leaders.
The Role of The Press Council in Enforcement of The Press Law
Authors: Firdausi Indrianti Azhar
Published: January 2022

This study aims to examine the role of the press council in enforcing the press law and journalistic code of ethics where digital developments are currently very developed, especially media that utilize new media platforms. Not all online mass media are legal entities and not all news that is conveyed through online media follows a journalistic code of ethics, giving rise to overlapping perceptions and activities due to the lack of understanding of journalists and the public in the midst of easy access to information. This research uses a descriptive qualitative approach with a case study method, data collection is collected through observation and documentation sourced from literature and document studies that examine the phenomenon of digitalization dynamics around press laws and journalistic codes of ethics. There are a number of efforts from the press council, including enforcing the press law on online mass media by carrying out a number of verification processes including administrative verification, factual verification and content verification. The third verification cannot be carried out because of the constraints of human resources and budget. A mass media that receives a report will be handled and mediated by the press council if the mass media is already a legal entity. Meanwhile, the enforcement of the press code of ethics is carried out by first classifying journalism activities based on whether the mass media is a legal entity or not, then screening complaints of violations of the code of ethics, and reprimanding the problematic mass media to apologize and clarify the misinformation that has been published.
Evaluation Performance Covid-19 Tasikmalaya Task Unit
Authors: Kusumah Danial , Aji Dede
Published: January 2022

The role of the Covid-19 Task Force determines the effectiveness of handling the pandemic in Tasikmalaya City. Performance evaluation is an instrument to measure the gap between the established policies and the resulting achievements. The analytical method in this study uses a literature study through a qualitative approach. By using the indicators of transparency, participation, responsiveness, and accountability, it was found that the Covid-19 Task Force has shown good performance in efforts to accelerate the handling of the corona virus in the City of Tasikmalaya. However, continuous performance improvement is needed to be able to significantly reduce the number of positive cases
Um vazio paradoxal? Entre pascal e a psicanálise
Authors: Beserra Abel dos Santos
Published: January 2022

O presente artigo procura desvelar como Pascal e a abordagem psicanalítica, em sua vertente freudiana e lacaniana, pensaram a experiência de um ser humano finito diante de uma situação paradoxal. Com efeito, as propostas da psicanálise e de Pascal, embora separadas por mais ou menos dois séculos, apresentam pontos comuns que talvez ajudem a elucidar suas próprias posições. Nesse cenário, a hipótese que discutimos a seguir é a de que tanto Pascal quanto a psicanálise tecem suas categorias a partir de uma observação atenta do comportamento do homem que procura compreender o porquê de uma constante sensação de vazio marcar a experiência humana. Assim, nossa investigação será realizada por meio, de um lado, do cotejo dos conceitos pascalianos de divertissement e de graça com, de outro lado, as ideias metapsicológicas de das Ding, de representação, de pulsão e de fantasia da psicanálise.
Ética, de Baruch de Espinosa
Authors: Oliva Luís César Guimarães
Published: January 2022

Resenha da tradução da Ética, de Baruch de Espinosa, da Editora Relógio d'Água (2020)
Espinosa: a política da liberdade
Authors: Chaui Marilena de Souza
Published: January 2022

Resenha do livro Conflito e resistência na filosofia política de Espinosa, de Daniel Santos da Silva
Notícias
Authors: Espinosanos Cadernos
Published: January 2022

Notícias do segundo semestre de 2021
Transformações da China narradas pela literatura em língua portuguesa
Authors: Antunes Sérgio Pereira
Published: January 2022

Desde o final do século XIX, a China vem passando por marcantes transformações econômicas, culturais, sociais, enfim transformações de todos os tipos. Neste mundo globalizado, as notícias a esse respeito chegam ao Ocidente e, em especial, ao Brasil, sempre intermediadas pelos grandes e poderosos grupos da mídia mundial. A literatura em língua portuguesa, por sua vez, com toque próprio da latinidade, em diferentes momentos históricos destes últimos 110 anos, no apresenta essas transformações em relatos interessantíssimos de Wenceslau de Moraes, Ligia Fagundes Telles, Henfil, João Alves entre outros. As transformações da China podem, portanto, ser aprendidas por testemunhos oculares e com delicioso toque literário.
Um breve percurso histórico sobre o Budō: de arte marcial japonesa à prática esportiva mundial
Authors: Ito Narumi
Published: January 2022

O presente artigo tem como objetivo principal apresentar o conceito de Budō (caminho do guerreiro), traçando um percurso histórico desde o que compreendemos como arte marcial tradicional japonesa até a contemporaneidade. O Budō passou por transformações que causaram alterações em seu significado, sendo hoje considerado uma prática esportiva através de artes marciais como o Aikidō, Judō, Iaidō, Karatê, Kendō e Kyudō e outras. Para tanto, foi de suma relevância a reflexão e discussão em torno do equilíbrio entre os aspectos físico e mental como um de seus princípios, além de aprofundarmos sobre o bushidō (código de honra dos bushi). Desse modo, percebemos que este é um assunto que ainda foi pouco explorado em pesquisas brasileiras e que possui amplo potencial para pesquisas posteriores.
Fábulas do “Consolo dos Poderosos”
Authors: Jarouche Mamede Mustafa , Criado Pedro Martins
Published: January 2022

Composto no século XII na Sicília muçulmana pelo letrado mequense Muhammad Ibn Zafar (1104-1169), o "Consolo dos Poderosos" se insere na longa linhagem, fundada por Ibn Almuqaffa' no século VIII, de tratados políticos que se apresentam na forma de aconselhamentos aos reis e potentados para os quais foram escritos. Tais tratados eram acompanhados de amthal, "exempla", que podiam adquirir a forma de anedotas históricas ou semi-históricas, e, mais raramente, de fábulas. No presente trabalho, são traduzidas as fábulas constantes do capítulo quarto (ou "consolo quarto") desse trabalho, o único espelho de príncipes em árabe produzido na Sicília.
Contos folclóricos coreanos: perspectivas para uma tradução colaborativa no Brasil
Authors: Im Yun Jung , Girão Luis Carlos , Guimarães Carolina , Murari Jennifer , Torelli Laura , Brito Mariane , Okabayashi Natália
Published: January 2022

O presente texto pretende trazer uma reflexão breve sobre o processo de tradução colaborativa realizado pelo grupo de pesquisa "Hallyu - Estudos Coreanos" (CNPq/USP) para uma coletânea de contos folclóricos coreanos. Além de acompanhar o percurso de criação e estabelecimento do grupo-embrião, formado por pesquisadores ligados ao curso de Língua e Literatura Coreana da USP, pretendemos desenvolver uma discussão sobre dois aspectos tradutológicos que residem na base dessas composições ficcionais de extremo caráter oral: as onomatopeias e as expressões idiomáticas. Movidos por um pensar crítico ainda em desenvolvimento sobre o traduzir esse gênero popular da língua coreana para a língua portuguesa, questionamos e exemplificamos as escolhas feitas por quem traduz individualmente e as possibilidades de ampliação, revisão, retradução de termos, frases e construções quando se traduz coletivamente, nas trocas com outros que traduzem uma mesma obra. Por se tratar de um projeto de tradução em andamento, revisitamos alguns passos já dados e vislumbramos horizontes no que tange às metodologias testadas e aplicadas pelo grupo, assim como apontamos desafios presentes no exercício de traduzir de maneira coletiva, seja na teoria, seja na prática. O que apresentamos aqui é apenas um resultado parcial do que estamos ensaiando enquanto tradutores em formação na coletividade, todos com os olhares dirigidos a um título de construções poéticas tão plurais quanto quem integra o grupo.
Pericoronary Fat Attenuation Index Is Associated With Vulnerable Plaque Components and Local Immune‐Inflammatory Activation in Patients With Non‐ST Elevation Acute Coronary Syndrome
Authors: Sun Jia Teng , Sheng Xin Cheng , Feng Qi , Yin Yan , Li Zheng , Ding Song , Pu Jun
Published: January 2022

Background

The pericoronary fat attenuation index (FAI) is assessed using standard coronary computed tomography angiography, and it has emerged as a novel imaging biomarker of coronary inflammation. The present study assessed whether increased pericoronary FAI values on coronary computed tomography angiography were associated with vulnerable plaque components and their intracellular cytokine levels in patients with non‐ST elevation acute coronary syndrome.

Methods and Results

A total of 195 lesions in 130 patients with non‐ST elevation acute coronary syndrome were prospectively included. Lesion‐specific pericoronary FAI, plaque components and other plaque features were evaluated by coronary computed tomography angiography. Local T cell subsets and their intracellular cytokine levels were detected by flow cytometry. Lesions with pericoronary FAI values >−70.1 Hounsfield units exhibited spotty calcification (43.1% versus 25.0%,
P
=0.015) and low‐attenuation plaques (17.6% versus 4.2%,
P
=0.016) more frequently than lesions with lower pericoronary FAI values. Further quantitative plaque compositional analysis showed that increased necrotic core volume (Pearson’s r=0.324,
P
<0.001) and fibrofatty volume (Pearson’s r=0.270,
P
<0.001) were positively associated with the pericoronary FAI, and fibrous volume (Pearson’s r=−0.333,
P
<0.001) showed a negative association. An increasing proinflammatory intracellular cytokine profile was found in lesions with higher pericoronary FAI values.

Conclusions

The pericoronary FAI may be a reliable indicator of local immune‐inflammatory response activation, which is closely related to plaque vulnerability.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT04792047.
Neuromodulation of Inflammation to Treat Heart Failure With Preserved Ejection Fraction: A Pilot Randomized Clinical Trial
Authors: Stavrakis Stavros , Elkholey Khaled , Morris Lynsie , Niewiadomska Monika , Asad Zain Ul Abideen , Humphrey Mary Beth
Published: January 2022

Background

A systemic proinflammatory state plays a central role in the development of heart failure with preserved ejection fraction. Low‐level transcutaneous vagus nerve stimulation suppresses inflammation in humans. We conducted a sham‐controlled, double‐blind, randomized clinical trial to examine the effect of chronic low‐level transcutaneous vagus nerve stimulation on cardiac function, exercise capacity, and inflammation in patients with heart failure with preserved ejection fraction.

Methods and Results

Patients with heart failure with preserved ejection fraction and at least 2 additional comorbidities (obesity, diabetes, hypertension, or age ≥65 years) were randomized to either active (tragus) or sham (earlobe) low‐level transcutaneous vagus nerve stimulation (20 Hz, 1 mA below discomfort threshold), for 1 hour daily for 3 months. Echocardiography, 6‐minute walk test, quality of life, and serum cytokines were assessed at baseline and 3 months. Fifty‐two patients (mean age 70.4±9.2 years; 70% female) were included (active, n=26; sham, n=26). Baseline characteristics were balanced between the 2 arms. Adherence to the protocol of daily stimulation was >90% in both arms (
P
>0.05). While the early mitral inflow Doppler velocity to the early diastolic mitral annulus velocity ratio did not differ between groups, global longitudinal strain and tumor necrosis factor‐α levels at 3 months were significantly improved in the active compared with the sham arm (−18.6%±2.5% versus −16.0%±2.4%,
P
=0.002; 8.9±2.8 pg/mL versus 11.3±2.9 pg/mL,
P
=0.007, respectively). The reduction in tumor necrosis factor‐α levels correlated with global longitudinal strain improvement (r=−0.73,
P
=0.001). Quality of life was better in the active arm. No device‐related side effects were observed.

Conclusions

Neuromodulation with low‐level transcutaneous vagus nerve stimulation over 3 months resulted in a significant improvement in global longitudinal strain, inflammatory cytokines, and quality of life in patients with heart failure with preserved ejection fraction.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03327649.