bluuebunny/crossref_metadata_2025 huggingface dataset:
Análise do perfil do estilo de vida de professores universitários e sua relação com a obesidade como fator de risco para morbidade
Authors: Queiroz Rayssa Soares de , Arantes Luciana Mendonça
Published: November 2021

A obesidade representa um preocupante problema de saúde pública por estar aumentando de maneira exorbitante, o que, consequentemente, eleva o risco para as morbidades associadas a ela, além de ser a principal causa de óbitos em pessoas com menos de 60 anos devido à COVID-19. O objetivo do presente estudo foi avaliar, por meio de questionário na plataforma do Google Forms, a qualidade de vida dos professores dos cursos de graduação do Centro Universitário de Patos de Minas (UNIPAM), verificando a importância dos exercícios físicos, tanto resistidos quanto aeróbios, no combate à obesidade como fator de risco para morbidade, bem como compará-los. Trata-se de um estudo transversal descritivo qualitativo-quantitativo, realizado através do Microsoft Excel 2016 e os resultados foram apresentados por meio de gráficos e tabelas. A amostra foi composta por 80 professores universitários do UNIPAM, em que 63,7% eram do sexo feminino e 36,3% eram do sexo masculino. Foi verificado que a maioria dos docentes, tanto dos cursos da área da saúde quanto dos cursos de outras áreas, se apresentaram eutróficos, porém os da área da saúde, relacionando-os com o IMC, possuem maior sobrepeso e obesidade, mas os desta área tiveram amostra maior (n 54). Diante dos dados levantados na pesquisa, conclui-se que ambos os cursos possuem a maioria da população eutrófica, mas ainda há uma quantidade significativa com sobrepeso e obesidade, além de que somente 42,5% não possuírem nenhuma patologia, sendo proposto que mais estudos sejam realizados para maiores resultados e conhecimentos.
Aspectos epidemiológicos da leishmaniose visceral no Estado da Bahia, Brasil
Authors: Cezar Isabela Santos , Abreu Jéssica Santos Dias de , Silva Dahara Keyse Carvalho , Meira Cássio Santana
Published: November 2021

O nordeste brasileiro destaca-se por ter uma elevada prevalência de leishmaniose visceral (LV), sendo indicado como a principal região endêmica do Brasil. Tal fato torna de grande valia estudos epidemiológicos na região, visto que ajudam a traçar políticas públicas de saúde mais assertivas para o controle da LV. Nesse contexto, a presente investigação visa delinear o perfil epidemiológico da LV entre os anos de 2007 e 2019 e traçar um perfil de vulnerabilidade frente a doença no estado da Bahia. Trata-se de um estudo seccional, de caráter exploratório, descritivo, quantitativo e retrospectivo. Os dados utilizados relacionados a casos de LV no estado da Bahia são provenientes da base de dados SINAN (Sistema de Informação e Agravos de Notificação). A análise dos dados foi realizada utilizado o programa GraphPad Prism. A Bahia representa o terceiro estado com maior número de casos notificados de LV no nordeste brasileiro entre os anos de 2007 e 2019, com um total de 4.156 casos notificados. Uma análise espacial dessa distribuição demonstra que Juazeiro (146 casos) e Guanambi (125 casos) são os municípios baianos com o maior número de casos notificados no período avaliado. Através de uma análise estratificada dos dados observamos uma maior vulnerabilidade entre os indivíduos do sexo masculino, pardos, com baixo nível de escolaridade e na faixa etária de 1-4 anos. Com o presente trabalho, reforçamos o caráter endêmico da leishmaniose visceral no estado da Bahia e a necessidade de adotar políticas públicas de saúde visando o combate a LV.
Comparison of the use of Solidago chilensis (Arnica) and low-level laser therapy for the prevention of oral mucositis in patients submitted of head and neck radiotherapy and/or high toxicity chemotherapy
Authors: Lopes Ana Cristina , Gonçalves Giovana Ferreira , Carneiro Anna Cecília Dias Maciel , Santos André Luiz Pantoja dos , Tomas Frederico Nobrega , Oliveira Leonardo Rodrigues de , Devienne Karina Ferrazzoli , Crema Virginia Oliveira
Published: November 2021

The oral mucositis is an adverse event of radiotherapy and/or high toxicity chemotherapy. The Solidago chilensis (Arnica) has been used for its antiseptic, analgesic, healing and anti-inflammatory properties. Objective: The purpose of this study was to evaluate the uses of Arnica for oral mucositis prevention in patients submitted to radiotherapy for head and neck tumors treatment and/or high toxicity chemotherapy. Methodology: The determination of the cytotoxicity index of the aqueous extract was determined in vitro. The oral mucosa was evaluated in days 0, 10 and 14 of patients in the groups: treated with lasertherapy (L, n=18), treated with Arnica (A, n=24) and, treated with lasertherapy associated with Arnica (LA, n=4). It was considered significant p<0.05. Results: It was determined IC50=90,74 μg/mL of Arnica’s aqueous extract in SCC-4 cells. The development of oral mucositis was associated with the type of treatment for oral mucositis prevention: L, A, and LA (χ2 = 24,72, p<0.0001). The level of oral mucositis had significant interaction with the type of prevention treatment [F(2) = 9.545, p<0.0001] and, within 14 days [F(2) = 11.995, p<0.0001]. Conclusions: The results obtained suggest which the use of Solidago chilensis (Arnica) can be an important therapeutic option for treatment with low-level laser therapy for oral mucositis prevention in patients submitted of head and neck radiotherapy and/or high toxicity chemotherapy.
Revisão bibliográfica: presença de microrganismos em aparelhos eletrônicos
Authors: Figueiredo Flaviane Scheeren , Costa Paula Fernanda Pinto da
Published: November 2021

A utilização de aparelhos eletrônicos como celulares, tablets, controles remotos, notebooks, computadores foi intensificada durante a pandemia da Covid-19, onde uma grande parte da população utilizou os serviços remotos abdicando os presenciais, como serviços de banco, compras online, encomendas, deliveries, educação, como forma de manter o distanciamento. O presente trabalho objetivou apontar os principais microrganismos presentes em aparelhos eletrônicos, as formas de contaminação e os métodos de controle reportados na literatura. A partir desta revisão foi possível perceber o potencial para veículo de microrganismos e propagação de doenças infecciosas presentes nesses objetos. Estes são contaminados através de contato direto com a pele ou por gotículas salivares. O tempo de permanência pode variar de dias a meses dependendo do microrganismo e do material da composição da superfície. Para a prevenção e controle, já estão disponíveis no mercado recursos como películas de revestimento, baseadas na nanotecnologia que apresentam atividade antimicrobiana, que podem limitar a propagação de microrganismos. No entanto, a pesquisa por agentes químicos destinados ao uso em aparelhos eletrônicos apresenta dados escassos. A partir desse estudo é compreendido a importância das medidas preventivas e cuidados na utilização de objetos que podem ser possíveis veículos para transmissão de patógenos, indicando-se a assepsia das mãos antes e após o uso dos aparelhos eletrônicos e também o uso de películas de revestimento com atividade antimicrobiana. A recomendação de álcool e outras substâncias químicas, apesar de comprovada eficácia, deve ser avaliada com cautela e deve-se seguir as recomendações dos fabricantes dos aparelhos eletrônicos.
Uma revisão narrativa sobre os principais resultados obtidos no estudo de turbulência noturna dentro e acima da floresta Amazônica através do sítio experimental Amazon Tall Tower Observatory
Authors: Costa Valkiria Andrade
Published: November 2021

Este artigo tem o objetivo de entender e documentar quais são os principais resultados obtidos dos estudos de eventos turbulentos intermitentes de intensidade e periodicidade variáveis, que fornecem conexão episódica junto do dossel e a atmosfera e podem provocar procedimentos oscilatórios na camada limite noturna (CLN) feitos exclusivamente no sítio experimental Amazon Tall Tower Observatory (ATTO) através de uma revisão narrativa de literatura dos principais artigos publicados durante o período de 2012 até 2021. Uma pesquisa bibliográfica foi realizada no banco de dados do projeto ATTO, acessado em 24 de setembro de 2021, onde esse banco de dados tem todas as publicações revisadas por pares em periódicos feitas no projeto ATTO entre 2012 a 2021. Todos os artigos foram revisados e destacados aqui de forma que os principais resultados fossem descritos, então a partir de 81 publicações no total desse banco de dados apenas 3 artigos são categorizados como estudos sobre eventos turbulentos intermitentes na CLN. Conclui-se que dentro do dossel, os fluxos de CO2 e o calor latente são dependentes dos processos com longas escalas de tempo. Visto que essa troca de baixa frequência inclina a ser aumentada em condições muito estáveis, o fluxo escalar total dentro do dossel pode ser maior em noites muito estáveis do que em noites fracamente estáveis. Em noites muito estáveis, os fluxos turbulentos são efetivamente suprimidos a 80 m, apontando que a espessura da camada limite rasa pode encontrar-se nessas situações.
Promoção da fitoterapia no emprego de plantas medicinais com ação neurológica: uma revisão integrativa
Authors: Lima Maria Alves de , Pereira Keliene , Souza Gabriel Oliveira de
Published: November 2021

Esta pesquisa teve como objetivo explanar que tipos de protocolos são aplicados para a utilização de plantas medicinais na atuação do sistema nervo, além de analisar a eficácia e segurança das plantas medicinais que agem no sistema neurológico. Para tanto, foram utilizadas as bases de dados eletrônicos MEDLINE/PUBMED, LILACS e SCIELO, que após critérios de exclusão e inclusão obteve-se x estudos. Os resultados mostraram que: Cymbopogon citratus e Melissa officinais apresentaram efeito sedativo e calmante, contra insônia e nervosismo, Curcuma longa L mostra potencial terapêutico no tratamento diversas doenças, inclusive no sistema nervoso central, Passiflora incarnara L. indicaram potencial efeito ansiolítico e sedativo, Lavandula officinalis é utilizado como óleo sendo essencial para uso através da aromoterapia, mostrando efeito calmante sedativo, a Petiveria alliace L. demostram desempenho sobre o sistema nervoso central. Conclui-se que apesar do potencial terapêutico das plantas medicinais frente aos distúrbios do sistema nervoso central, foram encontrados poucos estudos atualizados que avaliam a ação farmacológica dessas plantas medicinais. Vale ressaltar que esse estudo promove uma correlação entre o conhecimento popular e as diversas formas de aplicação do conhecimento científico dessas plantas medicinais.
Pengaruh Penambahan Tepung Biji Durian pada Pembuatan Bioplastik
Authors: Alfarisi Cory Dian , Fitri Yulia , Nisa Detria Khaerun
Published: November 2021

Plastic is a type of packaging that is often used in everyday life, however, in general, the plastic used is synthetic plastic which takes a very long time to decompose. Bioplastic is an environmentally friendly plastic film made from organic materials so that it can decompose naturally with the help of microorganisms. This study aims to determine the effects which have the potential as a supporting material in increasing bioplastic characteristics such as thickness, water absorption and biodegradation. The research method was to use experiment and analysis of varian. Durian seed flour is carried out through a process of sorting, washing, stripping, soaking, slicing, drying, packing and storing. Meanwhile, the method of making bioplastics is done by mixing tapioca flour, cornstarch, durian seed flour of adding various durian seed flour: 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 grams, distilled water, acetic acid and glycerin. The analysis results obtained on the test of bioplastic characteristics, namely, thickness test ranging from 0.63 mm - 0.84 mm and  water resistance test ranging from 71,43%-86,54% which water absorption test ranging from 13.46% - 28.57% and the biodegradability test ranging from 17.78% - 47 , 06%. 

Keywords: durian seeds, bioplastics, biodegradability, flour

ABSTRAK

Plastik adalah jenis pengemas yang sering dimanfaatkan dalam kehidupan sehari-hari, akan tetapi pada umumnya plastik yang digunakan merupakan plastik sintetik yang membutuhkan waktu yang sangat lama untuk  terurai. Bioplastik merupakan film plastik yang ramah lingkungan yang terbuat dari bahan-bahan organik sehingga dapat terurai secara alami dengan bantuan mikroorganisme. Penelitian ini bertujuan untuk mengetahui pengaruh penambahan tepung biji durian yang berpotensi sebagai bahan penunjang dalam meningkatkan karakteristik bioplastik seperti ketebalan, ketahanan terhadap air dan biodegradasi. Metode penelitian adalah menggunakan eksperimen dan sidik ragam data. Tepung biji durian dilakukan melalui proses penyortiran, pencucian, pengupasan, perendaman, pengirisan, pengeringan, penepungan dan penyimpanan. Sedangkan untuk metode pembuatan bioplastik dilakukan dengan mencampurkan tepung tapioka, tepung maizena, tepung biji durian dengan variasi: 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 gram, akuades, asam asetat dan gliserin. Hasil analisa yang didapat pada pengujian karakteristik bioplastik yaitu, uji ketebalan yang berkisar 0,63 mm – 0,84 mm, uji ketahanan terhadap air yang berkisar 71,43%-86,54% dengan penyerapan air berkisar 13,46 % - 28,57% dan uji biodegradibilitas yang berkisar 17,78% - 47,06%.

Kata kunci: biji durian, bioplastik, biodegradibilitas, tepung.
Antidiabetes Serbuk Umbi Tanaman Yakon (Smallanthus sonchifolius) pada Kadar Gula Darah Tikus Putih (Rattus norvegicus)
Authors: Nurmawati Thatit , Sari Yeni Kartika , Ningtyas Fina Ayu
Published: November 2021

The routine and long-term use of oral antidiabetic drugs in DM patients can make the public's perception worried about the side effects of the drug. In the Yakon (SS) plant tuber there is Fructooligosacaraide (FOS) which can reduce blood sugar levels. The research objective was to determine the effect of Yakon plant tubers on blood sugar levels in white rats with type 2 diabetes mellitus model. This type of research was experimental with a pre-post test design with control-group design. Independent variable, administration of Yakon plant tuber powder, dependent variable, blood glucose levels. The sample was divided into 2 groups (dose 1, dose 2) and a control group, each of 6 rats. The mice were given a high carbohydrate diet for 9 weeks. Treatment dose 1 (100 mg / kgBB) for 3 days. Measurement of blood sugar levels using Gluco-Dr. Data analysis used Paired Sample T-test, Independent Sample T-test, and One Way Anova. The results showed that the rats in the treatment group dose 1 experienced a decrease in the average blood sugar level of 122.83 mg / dl (p 0.002) (p 0.009). This shows that there is an effect of using Yakon plant tuber powder on blood sugar levels. The results of this study were the control group and the treatment group dose 1 (Sig. (2-tailed) = 0.000, α = 0.05). Meanwhile, the comparison results showed that there was a difference between the control group and the treatment group at dose 1, Based on the above research, Yakon tubers can be used to reduce blood sugar levels.
Pengaruh Ekstrak Daun Kopi Robusta (Coffea canephora Pierre ex A. Froehner) terhadap Kualitas Spermatozoa Mencit (Mus musculus L.) Yang Terpapar Asap Rokok.
Authors: Saputra I Komang Alit , Ermayanti Ni Gusti Ayu Manik , Sukmaningsih A.A. S. A.
Published: November 2021

This study aims to determine the effect of given robusta coffee (Coffea canephora Pierre ex A. Froehner) leaf extract on the spermatozoa quality of mice (Mus musculus L.) exposed to cigarette smoke. The experiment was using a completely randomized design (CRD) with five treatments and each consisted of six mice as replications. Each treatment was K- (without exposure to cigarette smoke), K+ (exposure to cigarette smoke + 0.5% Na-CMC), P1 (exposure to cigarette smoke + Robusta coffee leaf extract at a dose of 60 mg/kgbw), P2 (exposure to cigarette smoke + Robusta coffee leaf extract at a dose of 120 mg/kgbw) and P3 (exposure to cigarette smoke + Robusta coffee leaf extract at a dose of 180 mg/kgbw). On the 36th day, mice were taken down by anesthesia and followed by surgery to collect spermatozoa. The parameters for this observation were the concentration, motility, viability, morphology, and integrity of the spermatozoa membrane. The data obtained were analyzed statistically with One Way Anova and further tested with DMRT. The results showed that the treatment of robusta coffee leaf exstract in mice exposed to cigarette smoke had a significant effect (P<0,05) on the quality of spermatozoa.
Distribusi dan Frekuensi Alel Golongan Darah Sistem ABO dan Rhesus pada Penduduk Pulau Gili Ketapang Probolinggo
Authors: Rezki Kirana Eka , Oktarianti Rike , Wiyono Hidayat Teguh , Purwatiningsih Purwatiningsih
Published: November 2021

Sistem penggolongan darah pada manusia yang banyak dikenal adalah sistem ABO dan rhesus. Tujuan penelitian ini adalah Mengetahui distribusi golongan darah sistem ABO dan rhesus serta frekuensi alel pada populasi penduduk pulau Gili Ketapang, kabupaten Probolinggo. Pengambilan sampel dilakukan secara acak dengan cara dilakukan pengundian jumlah sampel yang diambil sebanyak 384 jiwa. Identifikasi golongan darah sistem ABO pada penelitian ini dilakukan dengan metode slide dengan prinsip antigen (aglutinogen) yang direaksikan dengan antibodi (aglutinin).  Hasil penelitian menunjukkan distribusi  golongan darah sistem ABO dan Rhesus O+ (46,61%), B+ (24,22%), A+ (23,18%), dan AB+ (5,99%). Frekuensi alel IA(0,16), frekuensi alel IB (0,16),  frekuensi alel i (0,68), dan frekuensi alel rhesus positif (Rh+) adalah 1
Correlates of evidence-based nursing practice among nurses in Saudi Arabia: A structural equation model
Authors: Abuadas Mohammad H
Published: November 2021

Background: Consideration needs to be given to variables that impact the application of evidence-based nursing practice.
Objective: This study aimed to generate and validate a structural model of factors predictive of evidence-based nursing practice.
Methods: A cross-sectional descriptive design was used, with 612 registered nurses in the southern area of Saudi Arabia selected using a convenience sampling procedure. Data were collected during the period from November 2019 to January 2020 using valid and reliable questionnaires, including the novel Registered Nurses’ Competencies, Beliefs, Facilitators, Barriers, and Implementation of the Evidence-based Practice Questionnaire. A structural equation modeling technique was used for data analysis.
Results: Evidence-based nursing practice was significantly influenced by nurses’ competency, beliefs, barriers, and facilitators. 38.75% of the variance was explained by all factors. Specifically, nurses’ beliefs partially mediated the relationship between nurses’ competency and the evidence-based application of nursing practice. In addition, the relationship between nurses’ beliefs and evidence-based application of nursing practice was partially mediated by organizational facilitators. Nurses’ competency and beliefs were significantly influenced by attending the workshop, education level, years of experience, and previous research work.
Conclusion: The current study highlights the significant effect of personal and organizational variables toward the application of evidence-based nursing practice.
FORMATION OF SUPPLY CHAINS FOR THE TRANSPORT OF PERISHABLE GOODS
Authors:   National Transport University, Kyiv, Ukraine, T Anufriyeva
Published: November 2021

The article is a synthesis of theoretical approaches to the definition of «supply chain» and to consider the formation of supply chains, justifying the need to consider the conditions of transportation of perishable goods. In the article analyzes the main characteristics of the supply chain in which it differs from the usual shipping is that it, companies are partners, not competitors, which are set to profit by due to the optimal delivery of goods between all links of the chain. But do not take into account the characteristics of perishable products, which limits the use of existing supply chains for products with unlimited shelf life and requires research in the study of patterns of logistic chains delivering perishable goods. In the article found that the formation of the supply chain do not address specific delivery of perishable goods with limited shelf life. In Ukraine, the commercial merezhayi not always warehouses for storage of goods, so formuivanni supply chain must consider these characteristics and also in more detail to consider when choosing a model of supply chain management KEYWORDS: SUPPLY CHAIN, SUPPLY CHAIN LENGTH, WIDTH OF SUPPLY CHAIN, SHIPPING LOADS, TRADE NETWORKS.
MODELING AND CONFIGURING IP TELEPHONY IN THE PROCESS OF EMULATION OF NETWORKS BY MEANS OF CISCO PACKET TRACER SYSTEM
Authors:   National Transport University, Kyiv, Ukraine, O Budia , M Skopen ,   Kyiv University of Tourism, Economics and Law, Kyiv, Ukraine, O Havrylenko ,   NTUU «Igor Sikorsky KPI », Kyiv, Ukraine
Published: November 2021

This article discusses the features and specifics of IP telephony modeling on the Cisco Packet Tracer system platform. An algorithm for constructing a topology and a software code for configuring IP telephony in a data and voice network are presented. The proposed IP-telephony algorithm can be recommended for use in the training process as well as network simulation at the design stage. KEYWORDS: MODELING, DATA NETWORK, TOPOLOGY, CONFIGURATION, IP- TELEPHONY
THE FEATURES OF STRUCTURE PARAMETERS CHANGES Ag3AsS3 SEMICONDUCTOR
Authors:   National Transport University, Kyiv, Ukraine, Y Gololobov , N Borovoy ,   Taras Shevchenko Kyiv National University, Kyiv, Ukraine, A Nikolaienko ,   Taras Shevchenko Kyiv National University, Kyiv,
Published: November 2021

Influence of temperature and optical irradiation is investigated on the parameters of elementary cell and linear coefficients of thermal expansion of Ag3AsS3 proustite crystals. Object of the study - single-crystals of compounds - semiconductor Ag3AsS3. Purpose of the study - to determine an elementary cell parameters change features of Ag3AsS3crystals in the interval of temperatures of T= 120-300 К with presence of optical irradiation. Method of the study - X-rays metod. Temperature dependences of the elementary cell parameters and also linear coefficients of thermal expansion of crystals of proustite Ag3AsS3 are investigated in the temperature range of T=120 - 300 K both in the darken mode and with an intensive laser irradiation. It is discovered, that there is a change of the parameter Ac «0,003A as a height at cooling and reduction at heating at the temperature of T «150 K on condition of laser irradiation. The jump of values of parameter of elementary cell represents the change of character of processes of deserializing of cations of Ag+ in transition from the darken mode to the intensive laser irradiation, because the size of silver ions transition potential barrier between octahedral cavities change as a jump. KEY WORDS: CRYSTALLINE STRUCTURE, PHASE TRANSITION, PARAMETERS OF ELEMENTARY CELL, PROUSTITE.
PROJECT COMMUNICATION MANAGEMENT METHODS
Authors:   National Transport University, Kyiv, Ukraine, I Lebid , V Tkachenko ,   National Transport University, Kyiv, Ukraine, R Lysak ,   National Transport University, Kyiv, Ukraine, A Khrutba ,   Taras Shevchenko National University, Kyiv, Ukraine
Published: November 2021

The effectiveness of the process of solving contemporary social problems is greatly enhanced by the application of models and methods of project management. Projects that have many stakeholders and project team members from various industries have gained considerable popularity and are called distributed. Higher education institutions often introduce “flexible projects” into the educational process, which, when preparing specialists for different industries, contribute to the formation of their respective competences. The process of implementing such projects goes through mini-cycles and involves a complex and extensive communication system, especially with the external environment. The purpose of the work is to choose the method of communication management in different types of projects. The features of communication management in flexible projects are defined in the article and the analysis of existing methods of communication on the example of environmental educational projects is carried out. The method of expert evaluation has identified effective methods of communication in flexible projects, namely educational, environmental and scientific, since the success of their implementation is the basis for the further formation of a stable internal environment of our country. For educational and scientific projects, the most effective are the written methods of communication, while the implementation of environmental projects, electronic communications are the most successful. KEYWORDS: COMMUNICATION MANAGEMENT, FLEXIBLE PROJECTS, ENVIRONMENTAL PROJECTS, EDUCATIONAL PROJECTS, RESEARCH PROJECTS, COMMUNICATION PROCESS.
POSTULATION AND BUILDING OF A NUMERICAL ALGORITHM FOR SOLVING THE PROBLEMS OF THE DYNAMICS OF THE THEORY OF CONICAL SHELLS IN NONORTHOGONAL COORDINATE SYSTEM
Authors:   National Transport University, Kyiv, Ukraine, Y Meish , V Meish ,   Timoshenko Institute of Mechanics of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
Published: November 2021

The paper presents the formulation and numerical algorithm for solving problems of the dynamics of the theory of conical shells in a non-orthogonal coordinate system. The object of the study are conical shells, the equations of which are represented in non-orthogonal coordinate system. Purpose of the work is to formulate and construct a numerical algorithm for solving the problems of the dynamics of conical shells in a non-orthogonal coordinate system. The methods of research include the basic principles of the theory of shells to Tymoshenko's type and numerical methods. The formulation of problems and a numerical algorithm for studying the dynamic behavior of conical shells in a non-orthogonal coordinate system are considered. The results obtained in the work can be used in the design of elements of shell structures in the rocket, aircraft and shipbuilding industries. KEYWORDS: CONIC SHELL, DYNAMIC PROCESSES, NON-ORTHOGONAL COORDINATE SYSTEM, NUMERICAL METHODS
CREATING OF AUTOSERVICE ENTERPRISES FUNCTIONAL MODEL
Authors:   Cherkasy State Technological University, Cherkasy, Ukraine,, L Tarandushka
Published: November 2021

This article analyzes the latest trends in the transport industry and information technology. Functional model of auto-service enterprise (ASE) has been constructed, which together with its parametric and morphological description gives an opportunity to evaluate internal and external factors that affect the quality of services performed and to identify options for improving the properties of the enterprise. The process of ASE functioning was divided into 8 levels, each of which has a specific purpose. Levels A, C, E, G are responsible for executing subprocesses and B, D, F, H for improving them. In the main process, the following main subprocesses were identified: “Planning and maintenance of the activity of the ASE”, “Ensuring the implementation of technological processes”, “Control over the activity of the ASE”, “Optimization of the activity of the ASE on the basis of the intellectual system”. In addition, for all subprocesses the moments of bilateral influence of the environment and the processes of operation of the ASE are defined. The connection between these subprocesses and the external environment is provided by external and internal energy, mass and information flows that form the database of input and output data. Each subprocess can be improved by correcting the data after analyzing the constraints. Improvement of subprocesses is based on optimization methods and models, including models of inventory management with limited storage capacity. The use of intelligent process control systems and decision support systems is envisaged. On the basis of the proposed functional model and its description, it becomes possible to carry out a mathematical description of ASE main operation subprocesses, to develop algorithms of software modules for automated control over the production process of car services and their improvement, which will be included in the integrated quality management system. KEYWORDS: AUTOSERVICE ENTERPRISE, FUNCTIONAL MODEL, PRODUCTION PROCESS, QUALITY
FACTORS AFFECTING THE FORMATION AND DEVELOPMENT OF THE MULTIMODALINE TRANSPORT SYSTEM OF UKRAINE IN MODERN CONDITIONS
Authors:   National Transport University, Kyiv, Ukraine, S Shyriaieva
Published: November 2021

The article deals with the main factors influencing the formation and development of the multimodal transport system of Ukraine in modern conditions. The object of the research is the process of formation of the domestic multimodal transport system. The purpose of the work is to determine the necessary measures for the formation of the multimodal transport system of Ukraine. In Ukraine, multimodal transportation is at the initial stage of development. Among the main factors hindering the formation and development of multimodal transport systems in Ukraine, is the imperfection of regulatory legal regulation of multimodal transport issues; absence of own environmentally friendly rolling stock of different types of transport, especially on road transport, which carries out transportation on long distances; imbalance between levels of capacity of objects of multimodal transport infrastructure and volumes of cargo flows; high risks of multimodal carriers at significant distances with two or more modes of transport; political situation in Ukraine; information provision of all parts of the multimodal logistics chain, etc. To solve these problems, measures have been proposed that will allow the formation and development of the multimodal transport system of Ukraine. The results of the work can be applied for the formation of a national multimodal transport system. Foreseeable assumptions about the development of the research object - the study of the components of the multimodal transport system. KEYWORDS: MULTIMODAL TRANSPORTATION, MULTIMODALINE TRANSPORTATION SYSTEM
Academic Council Meeting of the RIEPL, Timed to Celebrate the 50th Anniversary of the Institute
Authors: Bitkina Inna
Published: November 2021

The article is devoted to the solemn meeting of the Academic Council of the Russian Research Institute of Economics, Politics and Law in Science and Technology (RIEPL), on the occasion of its 50th anniversary. The ceremony of awarding the employees of RIEPL and the election of new members of the Academic Council took place. Participants of the meeting discussed issues devoted to the most topical problems, tasks and trends in the field of science governance.
Integrative Studies of Human Cord Blood Derived Mononuclear Cells and Umbilical Cord Derived Mesenchyme Stem Cells in Ameliorating Bronchopulmonary Dysplasia
Authors: Chen Jia , Chen Yuhan , Du Xue , Liu Guojun , Fei Xiaowei , Peng Jian Ru , Zhang Xing , Xiao Fengjun , Wang Xue , Yang Xiao , Feng Zhichun
Published: November 2021

Bronchopulmonary dysplasia (BPD) is a common pulmonary complication observed in preterm infants that is composed of multifactorial pathogenesis. Current strategies, albeit successful in moderately reducing morbidity and mortality of BPD, failed to draw overall satisfactory conclusion. Here, using a typical mouse model mimicking hallmarks of BPD, we revealed that both cord blood-derived mononuclear cells (CB-MNCs) and umbilical cord-derived mesenchymal stem cells (UC-MSCs) are efficient in alleviating BPD. Notably, infusion of CB-MNCs has more prominent effects in preventing alveolar simplification and pulmonary vessel loss, restoring pulmonary respiratory functions and balancing inflammatory responses. To further elucidate the underlying mechanisms within the divergent therapeutic effects of UC-MSC and CB-MNC, we systematically investigated the long noncoding RNA (lncRNA)–microRNA (miRNA)–messenger RNA (mRNA) and circular RNA (circRNA)–miRNA–mRNA networks by whole-transcriptome sequencing. Importantly, pathway analysis integrating Gene Ontology (GO)/Kyoto Encyclopedia of Genes and Genomes (KEGG)/gene set enrichment analysis (GSEA) method indicates that the competing endogenous RNA (ceRNA) network is mainly related to the regulation of GTPase activity (GO: 0043087), extracellular signal-regulated kinase 1 (ERK1) and ERK2 signal cascade (GO: 0070371), chromosome regulation (GO: 0007059), and cell cycle control (GO: 0044770). Through rigorous selection of the lncRNA/circRNA-based ceRNA network, we demonstrated that the hub genes reside in UC-MSC- and CB-MNC-infused networks directed to the function of cell adhesion, motor transportation (Cdk13, Lrrn2), immune homeostasis balance, and autophagy (Homer3, Prkcd) relatively. Our studies illustrate the first comprehensive mRNA–miRNA–lncRNA and mRNA–miRNA–circRNA networks in stem cell-infused BPD model, which will be valuable in identifying reliable biomarkers or therapeutic targets for BPD pathogenesis and shed new light in the priming and conditioning of UC-MSCs or CB-MNCs in the treatment of neonatal lung injury.
A Critical Review on the Standardization and Quality Assessment of Nonfunctional Laboratory Tests Frequently Used to Identify Inborn Errors of Immunity
Authors: Perazzio Sandro Félix , Palmeira Patricia , Moraes-Vasconcelos Dewton , Rangel-Santos Andréia , de Oliveira João Bosco , Andrade Luis Eduardo Coelho , Carneiro-Sampaio Magda
Published: November 2021

Inborn errors of immunity (IEI), which were previously termed primary immunodeficiency diseases, represent a large and growing heterogeneous group of diseases that are mostly monogenic. In addition to increased susceptibility to infections, other clinical phenotypes have recently been associated with IEI, such as autoimmune disorders, severe allergies, autoinflammatory disorders, benign lymphoproliferative diseases, and malignant manifestations. The IUIS 2019 classification comprises 430 distinct defects that, although rare individually, represent a group affecting a significant number of patients, with an overall prevalence of 1:1,200-2,000 in the general population. Early IEI diagnosis is critical for appropriate therapy and genetic counseling, however, this process is deeply dependent on accurate laboratory tests. Despite the striking importance of laboratory data for clinical immunologists, several IEI-relevant immunoassays still lack standardization, including standardized protocols, reference materials, and external quality assessment programs. Moreover, well-established reference values mostly remain to be determined, especially for early ages, when the most severe conditions manifest and diagnosis is critical for patient survival. In this article, we intend to approach the issue of standardization and quality control of the nonfunctional diagnostic tests used for IEI, focusing on those frequently utilized in clinical practice. Herein, we will focus on discussing the issues of nonfunctional immunoassays (flow cytometry, enzyme-linked immunosorbent assays, and turbidimetry/nephelometry, among others), as defined by the pure quantification of proteins or cell subsets without cell activation or cell culture-based methods.
Physical and Dosimetric Aspects of the Iridium-Knife
Authors: Roussakis Yiannis , Anagnostopoulos Georgios
Published: November 2021

The three-dimensional iridium-192 (192Ir) high-dose-rate (HDR) brachytherapy manifests itself as a high-precision, hypofractionated, dose-escalating, minimally invasive method in the armamentarium of contemporary radiation oncology clinical applications. In this study, the physical aspects of the 192Ir radionuclide are presented. Its dosimetric application in HDR brachytherapy for different anatomical sites (prostate, gynecological malignancies, liver, and intrathoracic tumors) as well as the corresponding dosimetric comparison with the stereotactic body radiation therapy (SBRT) techniques based on a representative selection of dosimetric publications is reviewed and illustrated.
Navigating Calcium and Reactive Oxygen Species by Natural Flavones for the Treatment of Heart Failure
Authors: Yu Tianhao , Huang Danhua , Wu Haokun , Chen Haibin , Chen Sen , Cui Qingbin
Published: November 2021

Heart failure (HF), the leading cause of death among men and women world-wide, causes great health and economic burdens. HF can be triggered by many factors, such as coronary artery disease, heart attack, cardiomyopathy, hypertension, obesity, etc., all of which have close relations with calcium signal and the level of reactive oxygen species (ROS). Calcium is an essential second messenger in signaling pathways, playing a pivotal role in regulating the life and death of cardiomyocytes via the calcium-apoptosis link mediated by the cellular level of calcium. Meanwhile, calcium can also control the rate of energy production in mitochondria that are the major resources of ROS whose overproduction can lead to cell death. More importantly, there are bidirectional interactions between calcium and ROS, and such interactions may have therapeutic implications in treating HF through finely tuning the balance between these two by certain drugs. Many naturally derived products, e.g., flavones and isoflavones, have been shown to possess activities in regulating calcium and ROS simultaneously, thereby leading to a balanced microenvironment in heart tissues to exert therapeutic efficacies in HF. In this mini review, we aimed to provide an updated knowledge of the interplay between calcium and ROS in the development of HF. In addition, we summarized the recent studies (in vitro, in vivo and in clinical trials) using natural isolated flavones and isoflavones in treating HF. Critical challenges are also discussed. The information collected may help to evoke multidisciplinary efforts in developing novel agents for the potential prevention and treatment of HF.
Black Carbon and Its Effect on Carbon Sequestration in Soil
Authors: Kopecký Marek , Kolář Ladislav , Váchalová Radka , Konvalina Petr , Batt Jana , Mráz Petr , Menšík Ladislav , Hoang Trong Nghia , Dumbrovský Miroslav
Published: November 2021

The properties of black carbon (BC) are described very differently in the literature, even when determined by the same methodological procedure. To clarify this discrepancy, BC was investigated in the clay Cambisols of southern Bohemia, Czech Republic, in groups of soils with lower and higher deposition of its atmospheric fallout. The BC determination was performed according to a modified method of Kuhlbusch and Crutzen (1995). The amount of the free light fraction, the occluded light fraction of soil organic matter and its ratio, the amount of heavy soil fraction DF, and its soil organic matter DFOM were determined. Other soil characteristics were identified. It was found that there are two very different types of BC in soils. Historical BC from biomass fires, and new, anthropogenic, from the furnace and transport fumes. Historical BC has a significant effect on the organic matter of the heavy soil fraction, on the ratio of the free and occluded soil organic matter fraction, and the number of water-resistant soil aggregates. Anthropogenic BC does not have this effect. Because this form of BC is not significantly stabilized by the colloidal mineral fraction, it is necessary to take general data on BC’s high stability and resistance to mineralization in the soil with circumspection.
Repurposing Eltrombopag for Multidrug Resistant Staphylococcus aureus Infections
Authors: Lee Hyunjung , Lee Jaehoan , Hwang Juchan , Park Sinyoung , Kim Namyoul , Kim Kideok , Lee Honggun , Shum David , Jang Soojin
Published: November 2021

The continuous rise of antimicrobial resistance urgently demands new therapeutic agents for human health. Drug repurposing is an attractive strategy that could significantly save time delivering new antibiotics to clinics. We screened 182 US Food and Drug Administration (FDA)-approved drugs to identify potential antibiotic candidates against Staphylococcus aureus, a major pathogenic bacterium. This screening revealed the significant antibacterial activity of three small molecule drugs against S. aureus: (1) LDK378 (Ceritinib), an anaplastic lymphoma kinase (ALK) inhibitor for the treatment of lung cancer, (2) dronedarone HCl, an antiarrhythmic drug for the treatment of atrial fibrillation, and (3) eltrombopag, a thrombopoietin receptor agonist for the treatment of thrombocytopenia. Among these, eltrombopag showed the highest potency against not only a drug-sensitive S. aureus strain but also 55 clinical isolates including 35 methicillin-resistant S. aureus (Minimum inhibitory concentration, MIC, to inhibit 50% growth [MIC50] = 1.4–3.2 mg/L). Furthermore, we showed that eltrombopag inhibited bacterial growth in a cell infection model and reduced bacterial loads in infected mice, demonstrating its potential as a new antibiotic agent against S. aureus that can overcome current antibiotic resistance.
A New Orthodontic-Surgical Approach to Mandibular Retrognathia
Authors: Vale Francisco , Queiroga Joana , Pereira Flávia , Ribeiro Madalena , Marques Filipa , Travassos Raquel , Nunes Catarina , Paula Anabela Baptista , Francisco Inês
Published: November 2021

(1) Background: Mandibular deficiency is one of the most common growth disorders of the facial skeleton. Recently, distraction osteogenesis has been suggested as the treatment of choice for overcoming the limitations of conventional orthognathic surgery; (2) Methods: A new custom-manufactured dental-anchored distractor was built and anchored in the first molar and lower canine. It consists of a stainless-steel disjunction screw, adapted and welded to the orthodontic bands through two 1.2 mm diameter connector bars with a universal silver-based and cadmium-free solder; (3) Results: The distractor described can be a useful tool to correct mandibular retrognathia and is better tolerated by patients, especially in severe cases; (4) Conclusions: The dental-anchored distractor increases the anterior mandibular bone segment without affecting the gonial angle or transverse angulation of the segments and avoids posterior mandibular rotation, overcoming the limitations of conventional surgical treatment.
Calcium Signaling Involves Na+/H+ Exchanger and IP3 Receptor Activation in T. cruzi Epimastigotes
Authors: Usorach Melina , Gimenez Alba Marina , Peppino Margutti Micaela , Racagni Graciela E. , Machado Estela E.
Published: November 2021

The calcium ion (Ca2+) plays a fundamental role in the metabolism and cell physiology of eukaryotic cells. In general, increases in cytosolic Ca2+ may come from both of the extracellular environment through specific channels and/or calcium release from intracellular stores. The mechanism by which the ion calcium (Ca2+) is released from intracellular stores in higher eukaryotes is well known; however, in lower eukaryotes is still a subject of study. In the present work, it was elucidated that Trypanosoma cruzi epimastigotes can release Ca2+ from intracellular stores in response to high osmolarity, in a process involving a protein kinase-regulated Na+/H+ exchanger present in the acidocalsisomes of the parasite. In addition, we demonstrated that epimastigote membranes are able to release Ca2+ in response to exogenous activators of both inositol 1,4,5-triphosphate (IP3) and Ryanodine receptors. Furthermore, we also summarize the involvement of calcium-related signaling pathways in biochemical and morphological changes triggered by hyperosmotic stress in T. cruzi epimastigotes.
Metabolic Profiles, Bioactive Compounds, and Antioxidant Capacity in Lentinula edodes Cultivated on Log versus Sawdust Substrates
Authors: Nam Miso , Choi Ji Yeon , Kim Min-Sun
Published: November 2021

Lentinula edodes (shiitake) is a popular nutritious edible mushroom with a desirable aroma and flavor. Traditional cultivation of L. edodes on beds of logs has been replaced by cultivation on sawdust, but the effects of cultivation changes on L. edodes mushrooms have not been well characterized. We determined the metabolic profile, bioactive compounds, and antioxidant capacity in L. edodes grown on log or sawdust substrates. Metabolic profiles of L. edodes extracts were determined by 1H nuclear magnetic resonance (NMR) and ultra-performance liquid chromatography to quadrupole time-of-flight mass spectrometry. Principal component analysis score plots from 1H NMR analysis showed clear differences between samples. Concentrations of primary metabolites, especially amino acids, generally decreased in L. edodes grown on logs compared to sawdust. Phenolic compounds showed variations in concentration depending on the cultivation method. Bioactive compounds and their antioxidant capacity were analyzed spectrophotometrically. L. edodes cultivated on logs had high concentrations of bioactive compounds with strong antioxidant capacity compared to L. edodes cultivated on sawdust. Thus, the concentration of primary metabolites was high in L. edodes grown on sawdust, which produces a high growth rate. In contrast, log-cultivated L. edodes, which were similar to wild mushrooms, had high levels of bioactive compounds and high antioxidant capacity. This information is useful for determining optimal cultivation conditions for nutritional and medicinal uses of L. edodes mushrooms.
Analyzing Large Microbiome Datasets Using Machine Learning and Big Data
Authors: Krause Thomas , Wassan Jyotsna Talreja , Mc Kevitt Paul , Wang Haiying , Zheng Huiru , Hemmje Matthias
Published: November 2021

Metagenomics promises to provide new valuable insights into the role of microbiomes in eukaryotic hosts such as humans. Due to the decreasing costs for sequencing, public and private repositories for human metagenomic datasets are growing fast. Metagenomic datasets can contain terabytes of raw data, which is a challenge for data processing but also an opportunity for advanced machine learning methods like deep learning that require large datasets. However, in contrast to classical machine learning algorithms, the use of deep learning in metagenomics is still an exception. Regardless of the algorithms used, they are usually not applied to raw data but require several preprocessing steps. Performing this preprocessing and the actual analysis in an automated, reproducible, and scalable way is another challenge. This and other challenges can be addressed by adjusting known big data methods and architectures to the needs of microbiome analysis and DNA sequence processing. A conceptual architecture for the use of machine learning and big data on metagenomic data sets was recently presented and initially validated to analyze the rumen microbiome. The same architecture can be used for clinical purposes as is discussed in this paper.
3D Printed Chromophoric Sensors
Authors: Brounstein Zachary , Ronquillo Jarrod , Labouriau Andrea
Published: November 2021

Eight chromophoric indicators are incorporated into Sylgard 184 to develop sensors that are fabricated either by traditional methods such as casting or by more advanced manufacturing techniques such as 3D printing. The sensors exhibit specific color changes when exposed to acidic species, basic species, or elevated temperatures. Additionally, material properties are investigated to assess the chemical structure, Shore A Hardness, and thermal stability. Comparisons between the casted and 3D printed sensors show that the sensing devices fabricated with the advanced manufacturing technique are more efficient because the color changes are more easily detected.