bluuebunny/crossref_metadata_2025 huggingface dataset:
TỔNG HỢP VÀ ĐÁNH GIÁ HOẠT TÍNH KHÁNG KHUẨN, KHÁNG NẤM VÀ ĐỘC TẾ BÀO CÁC DẪN CHẤT 2-METHYLIMIDAZOL-4,5-DICARBOXAMID BẤT ĐỐI XỨNG
Authors: Huỳnh Nguyễn Hoài Phương , Đỗ Viết Hoàng , Trương Phương , Võ Thị Cẩm Vân
Published: July 2023

Đặt vấn đề: Imidazol là khung cấu trúc dị vòng từ lâu đã nhận được nhiều sự quan tâm trong lĩnh vực hóa dược và xuất hiện trong nhiều hợp chất với hoạt tính kháng khuẩn, kháng nấm, kháng virus, kháng ung thư và giảm đau, kháng viêm. Chúng tôi chọn nghiên cứu các dẫn xuất của 2-methylimidazol-4,5-dicarboxamid và đánh giá hoạt tính kháng khuẩn, kháng nấm, độc tế bào trong nhóm cấu trúc này. Mục tiêu nghiên cứu: Tổng hợp các dẫn chất 2-methylimidazol-4,5-dicarboxamid bất đối xứng và thử hoạt tính kháng khuẩn, kháng nấm, độc tế bào. Đối tượng và phương pháp nghiên cứu: Đối tượng nghiên cứu là các dẫn chất 2-methylimidazol-4,5-dicarboxamid bất đối xứng. Các dẫn chất imidazol-4,5-dicarboxamid bất đối xứng được tổng hợp từ nguyên liệu đầu là 2-methylbenzimidazol thông qua 2 giai đoạn chính là tổng hợp acid imidazol dicarboxylic và tổng hợp diamid. Cấu trúc được xác định bằng các phương pháp phổ. Phương pháp thử hoạt tính kháng khuẩn: Phương pháp khuếch tán trên thạch. Phương pháp thử độc tính tế bào: đánh giá tỉ lệ tế bào sống bằng phương pháp MTT. Kết quả: 4 dẫn chất 2-methylimidazol-4,5-dicarboxamid bất đối xứng được tổng hợp thành công với hiệu suất trung bình (25−37% cho bước cuối). Cả 4 dẫn chất tổng hợp được đều không thể hiện hoạt tính trên các chủng vi khuẩn và vi nấm thử nghiệm, không thể hiện hoạt tính độc tế bào. Kết luận: 4 dẫn chất imidazol-4,5-dicarboxamid bất đối xứng không thể hiện hoạt tính trên kháng khuẩn kháng nấm trên các chủng khảo sát.
Investigation of Social Studies Teacher Candidates' Spiritual and Emotional Intelligence / Sosyal Bilgiler Öğretmeni Adaylarının Ruhsal ve Duygusal Zekâlarının İncelenmesi
Authors: DEMİR Yılmaz
Published: July 2023

Bu çalışmayla sosyal bilgiler öğretmeni adaylarının ruhsal ve duygusal zekâları ile akademik başarıları arasındaki ilişkiyi belirlemek ve ayrıca ruhsal ve duygusal zekâ düzeylerini çeşitli değişkenlere göre incelemek amaçlanmıştır. Bu doğrultuda nicel araştırma yöntemlerinden biri olan genel tarama deseni kullanılmıştır. Araştırmanın katılımcılarını 2022-2023 akademik yılı güz döneminde Kilis 7 Aralık Üniversitesi’nde öğrenim gören 169 sosyal bilgiler öğretmeni adayı oluşturmaktadır. Araştırmanın sonucunda sosyal bilgiler öğretmeni adaylarının akademik başarının iyi, ruhsal ve duygusal zekâ düzeylerinin ise yüksek düzeyde olduğu belirlenmiştir. Ayrıca katılımcıların akademik başarıları ile ruhsal ve duygusal zekâ düzeyleri arasında istatistiksel olarak anlamlı bir ilişkinin olduğu tespit edilmiştir. Katılımcıların ruhsal ve duygusal zekâ düzeylerinin cinsiyete göre anlamlı bir farka sahip olduğu; duygusal zekâ düzeylerinin sınıf düzeyine göre anlamlı bir fark gösterdiği ancak ruhsal zekâ düzeylerinin sınıf değişenine göre anlamlı bir farka sahip olmadığı belirlenmiştir. Bunların yanı sıra katılımcıların ruhsal ve duygusal zekâlarının yaş, sosyoekonomik durum, ebeveyn eğitim düzeyi, internette geçirdikleri süre, TV izleme süresi ve doğup büyüdükleri yerleşim yeri değişkenlerine göre anlamlı bir fark göstermediği sonuçlarına ulaşılmıştır.
Gender and Styles of Leadership in Higher Education
Authors: Renigunta Satya , Mohammed Lubna Ali
Published: July 2023

The presence and absence of differences in leadership styles of men and women were investigated and reviewed in many types of research. The expectations regarding leadership styles of gender stereotyping are that women are inter-oriented, whereas men are task oriented. In contrast to this stereotype, leadership styles are different for genders according to research studies. The current paper attempts to identify the prevalent styles of leadership between both genders, as well as identifies the predominant style of leadership in women in higher educational institutes. The results indicated that the transformational leadership is the most dominant leadership style across the higher educational institutes. It could be useful for academic leaders and be intended at increasing the efficiency of universities. That is by enhancing the capabilities of academic leaders and helping them achieve a profitable performance and productivity.
Supplemental Table 1 from Validating Wave 1 (2014) Urinary Cotinine and TNE-2 Cut-points for Differentiating Wave 4 (2017) Cigarette Use from Non-use in the United States Using Data from the PATH Study
Authors: Edwards Kathryn C. , Khan Asia , Sharma Eva , Wang Lanqing , Feng June , Blount Benjamin C. , Sosnoff Connie S. , Smith Danielle M. , Goniewicz Maciej L. , Pearson Jennifer , Villanti Andrea C. , Delnevo Cristine D. , Bover-Manderski Michelle T. , Hatsukami Dorothy K. , Niaura Raymond , Everard Colm , Kimmel Heather L. , Duffy Kara , Rostron Brian L. , Del Valle-Pinero Arseima Y. , van Bemmel Dana M. , Stanton Cassandra A. , Hyland Andrew
Published: July 2023

Supplemental Table 1 provides demographic and tobacco use characteristics of exclusive and polytobacco users.
Supplementary Table 3 from Sex-specific Associations between Body Mass Index and Thyroid Cancer Incidence among Korean Adults
Authors: Kim Kyoung-Nam , Kim Kyungsik , Lee Sangjun , Park Sue K.
Published: July 2023

Supplementary Table 3 shows the associations between body mass index (BMI) and thyroid cancer incidence in the Korean Multi-center Cancer Cohort (KMCC) using the Western BMI cutoff
Table S8 from Using DEPendency of Association on the Number of Top Hits (DEPTH) as a Complementary Tool to Identify Novel Colorectal Cancer Susceptibility Loci
Authors: Lai John , Wong Chi Kuen , Schmidt Daniel F. , Kapuscinski Miroslaw K. , Alpen Karen , MacInnis Robert J. , Buchanan Daniel D. , Win Aung K. , Figueiredo Jane C. , Chan Andrew T. , Harrison Tabitha A. , Hoffmeister Michael , White Emily , Le Marchand Loic , Pai Rish K. , Peters Ulrike , Hopper John L. , Jenkins Mark A. , Makalic Enes
Published: July 2023

Supplementary Table S8 shows the number of risk regions that are common to both CCFR and GECCO in stage 2 DEPTH analysis, as well as whether they are detected by logistic regression analysis or were in previous CRC GWAS studies.
Table S11 from Using DEPendency of Association on the Number of Top Hits (DEPTH) as a Complementary Tool to Identify Novel Colorectal Cancer Susceptibility Loci
Authors: Lai John , Wong Chi Kuen , Schmidt Daniel F. , Kapuscinski Miroslaw K. , Alpen Karen , MacInnis Robert J. , Buchanan Daniel D. , Win Aung K. , Figueiredo Jane C. , Chan Andrew T. , Harrison Tabitha A. , Hoffmeister Michael , White Emily , Le Marchand Loic , Pai Rish K. , Peters Ulrike , Hopper John L. , Jenkins Mark A. , Makalic Enes
Published: July 2023

Supplementary Table S11 shows the ranking of SNPs at the HLA locus.
Table S10 from Using DEPendency of Association on the Number of Top Hits (DEPTH) as a Complementary Tool to Identify Novel Colorectal Cancer Susceptibility Loci
Authors: Lai John , Wong Chi Kuen , Schmidt Daniel F. , Kapuscinski Miroslaw K. , Alpen Karen , MacInnis Robert J. , Buchanan Daniel D. , Win Aung K. , Figueiredo Jane C. , Chan Andrew T. , Harrison Tabitha A. , Hoffmeister Michael , White Emily , Le Marchand Loic , Pai Rish K. , Peters Ulrike , Hopper John L. , Jenkins Mark A. , Makalic Enes
Published: July 2023

Supplementary Table S10 shows the logistic regression summary statistics for both the CCFR and GECCO datasets.
Figure S2 from Results of an Open-label, Phase Ia/b Study of Pembrolizumab plus Olaratumab in Patients with Unresectable, Locally Advanced, or Metastatic Soft-Tissue Sarcoma
Authors: Schöffski Patrick , Bahleda Rastislav , Wagner Andrew J. , Burgess Melissa A. , Junker Niels , Chisamore Michael , Peterson Patrick , Szpurka Anna M. , Ceccarelli Matteo , Tap William D.
Published: July 2023

Figure S2: Waterfall plot for percent change in tumor size in cohort 1, cohort 2, and the dose-expansion cohort.
Supplementary Data S5 from Genomic Profiling of Metastatic Castration-Resistant Prostate Cancer Samples Resistant to Androgen Receptor Pathway Inhibitors
Authors: Menssouri Naoual , Poiraudeau Loïc , Helissey Carole , Bigot Ludovic , Sabio Jonathan , Ibrahim Tony , Pobel Cédric , Nicotra Claudio , Ngo-Camus Maud , Lacroix Ludovic , Rouleau Etienne , Tselikas Lambros , Chauchereau Anne , Blanc-Durand Félix , Bernard-Tessier Alice , Patrikidou Anna , Naoun Natacha , Flippot Ronan , Colomba Emeline , Fuerea Alina , Albiges Laurence , Lavaud Pernelle , van de Wiel Paul , den Biezen Eveline , Wesseling-Rozendaal Yvonne , Ponce Santiago , Michiels Stefan , Massard Christophe , Gautheret Daniel , Barlesi Fabrice , André Fabrice , Besse Benjamin , Scoazec Jean-Yves , Friboulet Luc , Fizazi Karim , Loriot Yohann
Published: July 2023

Supplementary Data 5 describes the germline mutations in DNA repair genes in patients enrolled in the study.
Supplementary Data S4 from Genomic Profiling of Metastatic Castration-Resistant Prostate Cancer Samples Resistant to Androgen Receptor Pathway Inhibitors
Authors: Menssouri Naoual , Poiraudeau Loïc , Helissey Carole , Bigot Ludovic , Sabio Jonathan , Ibrahim Tony , Pobel Cédric , Nicotra Claudio , Ngo-Camus Maud , Lacroix Ludovic , Rouleau Etienne , Tselikas Lambros , Chauchereau Anne , Blanc-Durand Félix , Bernard-Tessier Alice , Patrikidou Anna , Naoun Natacha , Flippot Ronan , Colomba Emeline , Fuerea Alina , Albiges Laurence , Lavaud Pernelle , van de Wiel Paul , den Biezen Eveline , Wesseling-Rozendaal Yvonne , Ponce Santiago , Michiels Stefan , Massard Christophe , Gautheret Daniel , Barlesi Fabrice , André Fabrice , Besse Benjamin , Scoazec Jean-Yves , Friboulet Luc , Fizazi Karim , Loriot Yohann
Published: July 2023

Supplementary Data 4 describes the results of mutational signatures of the whole cohort.
Supplementary Materials and Methods from Allele-specific Gene Regulation, Phenotypes, and Therapeutic Vulnerabilities in Estrogen Receptor Alpha–mutant Endometrial Cancer
Authors: Blanchard Zannel , Rush Craig M. , Arnesen Spencer , Vahrenkamp Jeffery M. , Rodriguez Adriana C. , Jarboe Elke A. , Brown Callie , Chang Matthew E.K. , Flory Mark R. , Mohammed Hisham , Modzelewska Katarzyna , Lum David H. , Gertz Jason
Published: July 2023

Supplementary Materials and Methods
Supplemental Figure 8 from Mitochondrial Uncoupling Inhibits Reductive Carboxylation in Cancer Cells
Authors: Jiang Haowen , He Clifford Jiajun , Li Albert M. , He Bo , Li Yang , Zhou Meng-Ning , Ye Jiangbin
Published: July 2023

S8. Mitochondrial uncoupling inhibits proliferation upon anchorage-independent growth.
Supplemental Figure 6 from Mitochondrial Uncoupling Inhibits Reductive Carboxylation in Cancer Cells
Authors: Jiang Haowen , He Clifford Jiajun , Li Albert M. , He Bo , Li Yang , Zhou Meng-Ning , Ye Jiangbin
Published: July 2023

S6. Mitochondrial uncoupling inhibits reductive carboxylation in ccRCC cells.
Supplementary Figure 1 from LncRNA-Encoded Micropeptide ACLY-BP Drives Lipid Deposition and Cell Proliferation in Clear Cell Renal Cell Carcinoma via Maintenance of ACLY Acetylation
Authors: Zhang Shenghua , Zhang Zheng , Liu Xiaolong , Deng Yibin , Zheng Jian , Deng Jieqiong , Wang Yirong , Guo Binbin , Li Fanrong , Chen Xiaoyue , Pan Yacheng , Wang Jieyu , Lu Jiachun , Wu Siqi , Guo Qiang , Zhou Yifeng
Published: July 2023

Screening of candidate lncRNAs and biologic characterization of LINC00887
Supplementary Figure S3 from Progressive Spreading of DNA Methylation in the GSTP1 Promoter CpG Island across Transitions from Precursors to Invasive Prostate Cancer
Authors: Gupta Harshath , Inoue Hitoshi , Nakai Yasutomo , Nakayama Masashi , Jones Tracy , Hicks Jessica L. , Kumar Balasubramanian , Gurel Meltem , Nelson William G. , De Marzo Angelo M. , Yegnasubramanian Srinivasan
Published: July 2023

Supplementary Figure S3 shows the GSTP1 promoter methylation and its corresponding GSTP1 immunohistochemistry expression for PIA and PIN lesions within an individual patient, and notably the heterogeneity of the PIA lesions.
Supplementary Figure S1 from RLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across FGFR2 Alterations and Resistance Mutations
Authors: Subbiah Vivek , Sahai Vaibhav , Maglic Dejan , Bruderek Kamil , Touré B. Barry , Zhao Songping , Valverde Roberto , O'Hearn Patrick J. , Moustakas Demetri T. , Schönherr Heike , Gerami-Moayed Nastaran , Taylor Alexander M. , Hudson Brandi M. , Houde Damian J. , Pal Debjani , Foster Lindsey , Gunaydin Hakan , Ayaz Pelin , Sharon Dina A. , Goyal Lipika , Schram Alison M. , Kamath Suneel , Sherwin Cori Ann , Schmidt-Kittler Oleg , Jen Kai Yu , Ricard Fabien , Wolf Beni B. , Shaw David E. , Bergstrom Donald A. , Watters James , Casaletto Jessica B.
Published: July 2023

Supplementary Figure 1. RLY-4008 is an irreversible inhibitor of FGFR2.
Supplementary Table S1 from Distinct Assemblies of Heterodimeric Cytokine Receptors Govern Stemness Programs in Leukemia
Authors: Kan Winnie L. , Dhagat Urmi , Kaufmann Kerstin B. , Hercus Timothy R. , Nero Tracy L. , Zeng Andy G.X. , Toubia John , Barry Emma F. , Broughton Sophie E. , Gomez Guillermo A. , Benard Brooks A. , Dottore Mara , Cheung Tung Shing Karen S. , Boutzen Héléna , Samaraweera Saumya E. , Simpson Kaylene J. , Jin Liqing , Goodall Gregory J. , Begley C. Glenn , Thomas Daniel , Ekert Paul G. , Tvorogov Denis , D'Andrea Richard J. , Dick John E. , Parker Michael W. , Lopez Angel F.
Published: July 2023

Data collection and refinement statistics for the IL-3R ternary complex crystal structure.
Figure S7 from Distinct Assemblies of Heterodimeric Cytokine Receptors Govern Stemness Programs in Leukemia
Authors: Kan Winnie L. , Dhagat Urmi , Kaufmann Kerstin B. , Hercus Timothy R. , Nero Tracy L. , Zeng Andy G.X. , Toubia John , Barry Emma F. , Broughton Sophie E. , Gomez Guillermo A. , Benard Brooks A. , Dottore Mara , Cheung Tung Shing Karen S. , Boutzen Héléna , Samaraweera Saumya E. , Simpson Kaylene J. , Jin Liqing , Goodall Gregory J. , Begley C. Glenn , Thomas Daniel , Ekert Paul G. , Tvorogov Denis , D'Andrea Richard J. , Dick John E. , Parker Michael W. , Lopez Angel F.
Published: July 2023

Increasing IL3Rα/βc ratios and enforced hexamer signaling lead to reduced differentiation in in vivo engraftments.
Data from Intratumoral Heterogeneity and Clonal Evolution Induced by HPV Integration
Authors: Akagi Keiko , Symer David E. , Mahmoud Medhat , Jiang Bo , Goodwin Sara , Wangsa Darawalee , Li Zhengke , Xiao Weihong , Dunn Joe Dan , Ried Thomas , Coombes Kevin R. , Sedlazeck Fritz J. , Gillison Maura L.
Published: July 2023

Abstract
The human papillomavirus (HPV) genome is integrated into host DNA in most HPV-positive cancers, but the consequences for chromosomal integrity are unknown. Continuous long-read sequencing of oropharyngeal cancers and cancer cell lines identified a previously undescribed form of structural variation, “heterocateny,” characterized by diverse, interrelated, and repetitive patterns of concatemerized virus and host DNA segments within a cancer. Unique breakpoints shared across structural variants facilitated stepwise reconstruction of their evolution from a common molecular ancestor. This analysis revealed that virus and virus–host concatemers are unstable and, upon insertion into and excision from chromosomes, facilitate capture, amplification, and recombination of host DNA and chromosomal rearrangements. Evidence of heterocateny was detected in extrachromosomal and intrachromosomal DNA. These findings indicate that heterocateny is driven by the dynamic, aberrant replication and recombination of an oncogenic DNA virus, thereby extending known consequences of HPV integration to include promotion of intratumoral heterogeneity and clonal evolution.
Significance:
Long-read sequencing of HPV-positive cancers revealed “heterocateny,” a previously unreported form of genomic structural variation characterized by heterogeneous, interrelated, and repetitive genomic rearrangements within a tumor. Heterocateny is driven by unstable concatemerized HPV genomes, which facilitate capture, rearrangement, and amplification of host DNA, and promotes intratumoral heterogeneity and clonal evolution.

See related video: https://vimeo.com/845407469

See related commentary by McBride and White, p. 814.

This article is highlighted in the In This Issue feature, p. 799
Supplementary Table 1 from Enhancing CAR T-cell Therapy Using Fab-Based Constitutively Heterodimeric Cytokine Receptors
Authors: Righi Matteo , Gannon Isaac , Robson Matthew , Srivastava Saket , Kokalaki Evangelia , Grothier Thomas , Nannini Francesco , Allen Christopher , Bai Yuchen V. , Sillibourne James , Cordoba Shaun , Thomas Simon , Pule Martin
Published: July 2023

Supplementary Table 1: Key Resources
Supplementary Figure S1-S26 from Enhancing CAR T-cell Therapy Using Fab-Based Constitutively Heterodimeric Cytokine Receptors
Authors: Righi Matteo , Gannon Isaac , Robson Matthew , Srivastava Saket , Kokalaki Evangelia , Grothier Thomas , Nannini Francesco , Allen Christopher , Bai Yuchen V. , Sillibourne James , Cordoba Shaun , Thomas Simon , Pule Martin
Published: July 2023

Supplementary Figure S1-S26
Supplementary Table 1 from Activating Inducible T cell Co-stimulator (ICOS) yields anti-tumor activity alone and in combination with anti-PD-1 checkpoint blockade
Authors: Yadavilli Sapna , Waight Jeremy D , Brett Sara , Bi Meixia , Zhang Tianqian , Liu Yao-Bin , Ellis Catherine , Turner David C , Hahn Ashleigh , Shi Hong , Seestaller-Wehr Laura , Jing Junping , Xie Qing , Shaik Jafar Sadik , Ji Xiao , Gagnon Robert , Fieles William , Hook Laura , Grant Steven , Hopley Stephanie , DeYoung M. Phillip , Blackwell Christina , Chisamore Michael , Biddlecombe Robert , Figueroa David J , Hopson Christopher B , Srinivasan Roopa , Smothers James , Maio Michele , Rischin Danny , Olive Daniel , Paul Elaine , Mayes Patrick A. , Hoos Axel , Ballas Marc
Published: July 2023

Antibodies used for in vitro and in vivo assays, and experimental
model
Supplementary Figure S9 from LNS8801 inhibits Acute Myeloid Leukemia by inducing the production of reactive oxygen species and activating the endoplasmic reticulum stress pathway
Authors: Lee Inyoung , Doepner Miriam , Weissenrieder Jillian S , Majer Ariana D , Mercado Sophia , Estell Angela , Natale Christopher A , Sung Pamela J , Foskett J. Kevin , Carroll Martin , Ridky Todd W
Published: July 2023

Supplementary Figure S9. Mcl-1 is not responsible for LNS8801-induced death in AML  (A) Proliferation assay dose curve of AML cells treated with the Mcl-1 specific inhibitor S63845. Cells were treated with drug for 72 hours. 6 replicates were used per dose. (B) Western blot of U937 cells overexpressing Mcl-1, treated with 250nM LNS8801 for 24 hours. (C) Annexin V flow analysis of U937 cells overexpressing Mcl-1. Cells were treated for 72 hours. 3 replicates were used per condition. Two-way ANOVA was used for statistical analysis for Annexin V+ flow cytometry comparing wild-type and Mcl-1 overexpressing U937 cells.
FIGURE 6 from A Th1-like CD4+ T-cell Cluster That Predicts Disease-free Survival in Early-stage Lung Cancer
Authors: Yanagihara Akitoshi , Yamasaki Satoshi , Hashimoto Kosuke , Taguchi Ryo , Umesaki Tetsuya , Imai Hisao , Kaira Kyoichi , Nitanda Hiroyuki , Sakaguchi Hirozo , Ishida Hironori , Kobayashi Kunihiko , Horimoto Katsuhisa , Kagamu Hiroshi
Published: July 2023

T-cell cluster changes after surgical resection. A, The percentages of CD62Llow CD4+ T cells and Th clusters in the CD62Llow CD4+ T-cell subpopulation were compared before and after surgical resection in patients with no recurrence and those with recurrence. Differences were tested using the paired Welch t test. B, The percentages of Th7R were compared between patients with no recurrence, patients with recurrence, and healthy controls. Differences were tested using ANOVA followed by Tukey multiple comparison test.
Generalized anxiety disorder screening using gad-7 among in-school adolescents of anambra state, nigeria: a comparative study between urban and rural areas
Authors: Victor Mbanuzuru Ahoma , Uwakwe Rechard , Sochukwu Anyaoku Chinekwu , Okwudili Ojimba Anastacia , Chinyere Mbanuzuru Mary , Ezenyeaku Chijioke Amara , Chukwudinma Obi Darlington , Nkiru Okafor Christiana , Prosper Okonkwo Uchenna
Published: July 2023

Background

Previous studies have reported that general anxiety disorder manifestations differ in diverse settings.

Objective

To determine and compare the prevalence of probable anxiety disorders among in-school adolescents in urban and rural areas of Anambra State.

Methods

A total of 1187 in-school adolescents were recruited using a multi-stage sampling technique. The study instrument was an interviewer-administered pretested questionnaire adopted from General Anxiety Disorder (GAD-7). Data were analyzed with the IBM Statistical Package for the Social Sciences (SPSS) version 22.

Result

One hundred and twenty of the participants out of the 1187 (10.1%) were found to have probable generalized anxiety disorders using GAD-7 as screening tool. The prevalence of symptoms of anxiety disorder revealed that urban participants had a higher prevalence compared to their rural counterparts (11% vs. 8.8%), while females had a higher prevalence compared to the males in the ratio of 3:2 (or 12% vs. 8%). The prevalence of symptoms of anxiety disorders among females was higher than that of males even when compared based on a rural and urban settings. When all other variables are held constant, urban participants were found to have a 50% higher chance of being identified with anxiety disorders compared to their rural participants (OR = 1.500, C.I.:1.002–2.246, p = 0.049).

Conclusion

The prevalence of probable anxiety disorders was found in 10% of the participants. The females have a higher propensity to exhibit symptoms of anxiety disorders than the males. Anxiety status affects how adolescents view their general health. The study started from the date of approval by the West African College of Physicians on the 21 February 2017, but Ethical Clearance from NAUTHEC was given on the 19th December 2016.
Identification of Arbuscular Mycorrhizal Fungi associated with Arabica coffee root (Coffea arabica) in the Arfak Mountains region of West Papua, Indonesia
Authors: SUPARNO ANTONIUS , PRABAWARDANI SARASWATI , NISA DENTYN K. , RUIMASSA REIMAS R.
Published: July 2023

Abstract. Suparno A, Prabawardani S, Nisa DK, Ruimassa RR. 2023. Identification of Arbuscular Mycorrhizal Fungi associated with Arabica coffee root (Coffea arabica) in the Arfak Mountains region of West Papua, Indonesia. Biodiversitas 24: 3207-3213. Coffee is a global commodity widely consumed as a beverage globally and has a high economy. Currently, the trend of drinking coffee is no longer dominated by older people but has become part of the millennial and celebrity lifestyle; therefore, worldwide demand for coffee continues to increase. Efforts to develop area expansion and productivity continue to be pursued. The Arfak Mountains Region of West Papua, located 800 - 2,500 m above sea level (masl), is a potential area for coffee plantations. The local farmers in this area have grown coffee independently and with gradual government support for the last years. Given the benefits of Arbuscular Mycorrhizal Fungi (AMF), which can increase plant growth and productivity, this study aims to identify the types of AMF that are associated with coffee plants in 4 districts, Mokwam, Anggi Giji, Anggi Gida, and Membey in Arfak Mountains region, West Papua. Identification of AMF types was observed based on the morphology of mycorrhizal spores. The research was conducted using the observation method with a purposive sampling technique from November 2022 to March 2023. Based on the observation, the coffee plants in 4 districts were associated with AMF. The types of AMF associated with coffee in Mokwam were more numerous than in other locations, namely the Acaulosporaceae Genus with five species, Glomeaceae Genus with five species, one species of Simiglomus sensu stricto, one species of Funneliformis sensu stricto, and one species of Septoglomus sensu stricto. AMF in Anggi Giji District consisted of Acaulosporaceae Genus with two species, Glomeaceae Genus with four species, while in Anggi Gida District consisted of Acaulosporaceae Genus with one species, Glomeaceae Genus with three species, one species Septoglomus sensu stricto. AMF species in the coffee plants of the Membey District are the Acaulosporaceae Genus with three species, the Glomeaceae Genus with two species, and one species of Septoglomus sensu stricto. From the soil analysis results, the soil fertility level is low; conversely, the mycorrhizal presence level is higher because of the more infertile soil, the more active mycorrhiza.
História do autismo: ideias, conceitos, práticas e instituições (1930-2010)
Authors: Passos-Santos João Paulo dos , Herold Junior Carlos
Published: July 2023

O livro “Outra Sintonia: a história do autismo” (In a Different Key: The Story of Autism), é de autoria dos norte-americanos John Donvan e Caren Zucker. Ele foi publicado nos Estados Unidos em 2016 e traduzido no Brasil em 2017 por Luiz Antônio de Araújo.Em relação aos autores, ambos possuem longa carreira no jornalismo Norte-Americano. Produzem materiais específicos sobre o autismo desde 2000. A obra é dividida em dez partes subdivididas em 46 subtítulos, caracterizadas pelo período histórico e fato principal - que nomeia a subseção -, desde o primeiro diagnóstico do autismo até os dias atuais. Ao final, tem-se um epílogo com uma cronologia do autismo, totalizando 563 páginas de texto.
Dementia and its Relations Between the Late 20th and 21st Century
Authors: Feo Gian Marco Di , Emond Michael , Ghassemkhani Kassra
Published: July 2023

This study was conducted to examine changes in the beliefs and contents of articles on dementia from the 20th century. Factors analyzed included the form of dementia, pharmaceutical drugs, source country and income of the first author, diagnostics, and the year of publication. All articles (N=202) analyzed were published between January 1st, 1984, and December 31st, 2022. Inter-rater reliability was assessed and there was an 89.4 percent agreement amongst raters. All articles were analyzed through both PubMed and PsycInfo. Our results proved that a significant number of articles discussed Alzheimer’s disease. Scientific perspectives on the cause of dementia have not changed significantly between the 20th and 21st century. Additionally, there were no significant differences between high-, middle- and low-income countries discussing pharmaceutical drugs in literature.
Findbuch des Bestandes Abt. 109
Authors: Pingel Wulf
Published: July 2023

Das vorliegende Findbuch schließt eine Lücke im Zugang zu der archivalischen Überlieferung des Kreises Stormarn. Erschlossen ist damit die heute im Landesarchiv Schleswig-Holstein verwahrte und als Abteilung 109 bezeichnete Überlieferung der drei Ämter Reinfeld, Rethwisch und Traventhal, die zusammen mit den Ämtern Reinbek, Trittau und Tremsbüttel ungefähr das Gebiet des heutigen Kreises Stormarn abdeckten. Ämter waren in den Herzogtümern Schleswig und Holstein bis 1867, also bis zum Beginn der preußischen Zeit, die unteren landesherrlichen Verwaltungsbezirke. Etwas vereinfacht kann man sie als die Vorgänger der heutigen Landkreise bezeichnen. Die Ämter hatten administrative, rechtliche und fiskalische Aufgaben wahrzunehmen.

Der mit diesem Findbuch jetzt komfortabel benutzbare Bestand der Abt. 109 umfasst 60 laufende Meter Archivalien, mit denen über dreihundert Jahre Stormarnscher Geschichte von der Mitte des 16. Jahrhunderts bis 1867 greifbar werden.

Die überlieferten Akten, Amts- und Protokollbücher sowie die nahezu lückenlos vorhandenen Amtsrechnungen dokumentieren die Sozial- und Alltagsgeschichte der ländlichen Bevölkerung, die wechselseitigen Beziehungen zwischen Stadt und Land, die Arbeit der Verwaltung und Rechtsprechung, die Entwicklung von Dienstleistungen und Steuern, aber auch die Auswirkungen kriegerischer Auseinandersetzungen auf die Ämter. Wer heute etwas über diese und ähnliche Themen zur Stormarnschen Geschichte wissen möchte, kann die einschlägigen Archivalien über eine sachthematische Systematik und zusätzlich über ein ausführliches Personen-, Orts- und Sachregister ermitteln.
On Problems in 2D Viscous Flows Simulation at Higher Values of the Reynolds Numbers by Vortex Methods Using the VM2D Code
Authors: Korobova Irina Aleksandrovna , Ryatina Evgeniya Pavlovna , Khorosheva Anna Aleksandrovna
Published: July 2023

Vortex methods of computational fluid dynamics are an efficient tool in engineering practice for estimating hydrodynamic loads acting on bodies placed in a flow. Their usage allows for solving of coupled hydroelastic problems with relatively small computational cost. In many applications, the cross flow around structural elements with large elongation is considered, that allows one to use the flat cross-sections method providing the acceptable accuracy. Thus, flat flows simulation around airfoils is required. Modern modifications of vortex particle methods make it possible to simulate flows of a viscous incompressible medium. Based on the method of viscous vortex domains in 2017-2022 the VM2D code have been developed in Bauman University and Ivannikov Institute for System Programming. This code allows for flow simulating around airfoils with acceptable accuracy at low Reynolds numbers, while for higher Reynolds numbers, correct results are observed only for airfoils with sharp edges and corner points, and only in regimes where the most intensive flow separation takes place at these points. The reason for the error in the results for other regimes is seen in incorrect modeling of the flow separation on smooth airfoil surface line at high Reynolds numbers, which, in turn, is a consequence of incorrect modeling of vorticity evolution in the vicinity of separation points (zones). Some results of flow simulations around different airfoils at different values of the Reynolds number are presented and a hypothesis explaining the reason for the discrepancy between numerical results and experimental data is proposed. It is shown that the kinetic energy spectrum of turbulence corresponds to “two-dimensional turbulence”.
Monitoring Convergence in the European Union with the convergEU Package for R
Authors: Stefanini Federico Mattia , Nikiforova Nedka Dechkova , Peruffo Eleonora , Bisello Martina , Litardi Chiara , Mascherini Massimiliano
Published: July 2023

Upward convergence, that is an improvement of Members States’ economic and social indicators’ performance, is a core policy target of the European Union. This concept isembodied in the European Pillar of social rights (EPSR) proclaimed by EU leaders in 2017. In 2018 Eurofound has developed a methodology to measure convergence, which has beenimplemented in the convergEU R package described in this work (rel. 0.5.0). The package extends the original STATA toolbox developed by Eurofound beyond the calculations ofthe four main measures of convergence as it provides functions to download, filter, impute, smooth indicators. Country and indicator fiches are automatically prepared and compiledin HTML format. Graphical output includes qualitative patterns of change along time to emphasize the key behaviour of an indicator with respect to the average of an aggregationof Member States. Besides EU Member States, the analysis of other collections of regions is supported for general indicators if context information is provided. A user-friendly,no coding required, shiny-based web application provides policy makers with a tool to produce convergence reports on selected indicators and countries.
TM Plane Wave Scattering from a Trapezoidal Cavity
Authors: Bozorgi Mehdi
Published: July 2023

The scattering problem of TM-plane wave from an isosceles trapezoidal cavity in a perfect electric conductor (PEC) is investigated. The modal expansion method and region-matching technique are employed to obtain a rigorous solution for this problem. The analyzed region is divided into three sub-regions by two arc-shaped borders. The tangential fields in each sub-region are expanded by appropriate wave functions which satisfy the Helmholtz equation and boundary conditions, simultaneously. After applying the boundary conditions on the auxiliary borders, four algebraic equations are constructed and solved for the unknown coefficients of the series. Some comparisons are taken to verify the validity of the procedure used in this study. Also, some typical examples are given to inspect the effect of the trapezoidal cavity parameters on scattering patterns.
Potential cognitive and neural benefits of a computerised cognitive training programme based on Structure Learning in healthy adults: Study protocol for a randomised controlled trial.
Authors: Liu Chialun , Cheng Xiaoqin , Choo Boon Linn , Hong Min , Teo Jia Li , Koo Wei Ler , Tan Jia Yuan Janet , Ubrani Marisha Barth , Suckling John , Gulyás Balázs , Leong Victoria , Kourtzi Zoe , Sahakian Barbara , Robbins Trevor , Chen Annabel Shen-Hsing
Published: July 2023

Background: Cognitive flexibility refers to the capacity to shift between conceptual representations particularly in response to changes in instruction and feedback. It is enables individuals to swiftly adapt to changes in their environment and has significant implications for learning. The present study focuses on investigating changes in cognitive flexibility following an intervention programme – Structure Learning training.
Methods: Participants are pseudo-randomised to either the Training or Control group, while matched on age, sex, intelligence and cognitive flexibility performance. In the Training group, participants undergo around two weeks of training (at least 13 sessions) on Structure Learning. In the Control group, participants do not have to undergo any training and are never exposed to the Structure Learning task. The effects of Structure Learning training are investigated at both the behavioural and neural level. We measured covariates that can influence an individual’s training performance before the training phase and outcome measures that can potentially show training benefits after the training phase. At the behavioural level, we investigated outcomes in both cognitive and social aspects with a primary focus on executive functions. At the neural level, we employed a multi-modality approach and investigated potential changes to functional connectivity patterns, neurometabolites concentration in the frontal brain regions, and brain microstructure and myelination,
Discussion: We reported the development of a novel training program based on Structure Learning that aims to hone a general learning ability to potentially achieve extensive transfer benefits across various cognitive constructs. Potential transfer benefits can be exhibited through better performance in outcome measures between Training and Control participants, and positive associations between training performance and outcomes after the training in Training participants. Moreover, we attempt to substantiate behavioural findings with evidence of neural changes across different imaging modalities by the Structure Learning training.
Trial registration: National Institutes of Health U.S. National Library of Medicine ClinicalTrials.gov NCT05611788. Registered on 7 November 2022. Protocol version: 11 May 2023. https://clinicaltrials.gov/ct2/show/NCT05611788.
Risk factors for epidural anesthesia blockade failure in cesarean section: a retrospective study
Authors: Chao Wei-Hsiang , Cheng Wen-Shan , Hu Li-Ming , Liao Chia-Chih
Published: July 2023

Background:
Epidural anesthesia (EA) is the preferred regional anesthesia technique in pregnant women who require cesarean section for delivery. Failure of EA requires additional sedation or convert it into general anesthesia (GA). It may be hazardous during sedation or GA conversion due to a potentially difficult airway. Therefore, this retrospective study aimed to determine the risk factors for epidural failure during cesarean section anesthesia.
Methods:
We retrospectively analyzed parturients who underwent cesarean section under EA and catheterization at Chang Gung Memorial Hospital in Taiwan between January 1 and December 31, 2018. Patient data were collected from medical records. EA failure was defined as the administration of any intravenous anesthetic at any time during the cesarean section, converting it into GA or even tube GA.
Results:
A total of 534 parturients who underwent cesarean section were recruited for this study. Of these, 94 (17.6%) parturients experienced failure of EA during the cesarean section. Compared to the patients with successful EA, those with EA failure were younger (33.0 years vs. 34.7 years) and have received EA previously (60.6% vs. 37%), were parous (72.3% vs. 55%), and had a shorter waiting time (14.9 mins vs. 16.5 mins) (p < 0.05). Younger age (OR 0.91, 95% CI 0.86–0.95), history of epidural analgesia (OR 2.61, 95% CI 1.38–4.94), and shorter waiting time (OR 0.91, 95% CI 0.87–0.97) were estimated to be significantly associated with a higher risk of epidural anesthesia failure.
Conclusion:
The retrospective study found that parturients with younger age, previous epidural catheterization history, and inadequate waiting time may have a higher risk of EA failure. Previous epidural catheterization increases the risk of EA failure by 2.6-folds compared to those with no catheterization history.
Early-stage chronic venous disorder as a cause of leg pain overlooked for lumbar spinal disease
Authors: Yang Dong-Hoon , Kim Mansu , Yang Joong Won , Cho Jae Man , Kwon Heum Dai , Park Sang Jin
Published: July 2023

Leg pain can be caused by both lumbar spinal disease and chronic venous disorder (CVD) of leg veins, but their clinical differences have not been thoroughly investigated. This study aimed to determine the incidence of CVD among patients visiting a spine center for leg pain. A total of 196 cases underwent ultrasound examination with a diagnosis rate were 85.7% (168 cases). CVD-diagnosed cases were divided into two groups based on the severity of lumbar spinal disease. The Clinical grades, symptom areas, and symptom types were compared. The differences in symptom improvements with vasoactive medication were also assessed. The most common symptom area was calf then the foot in CVD, while calf then thigh in lumbar spinal disease. Tingling-paresthesia was the most common symptom type for both, with pain and cramping similarly common in CVD and pain more common than cramping in lumbar spinal disease. Considering that the majority of CVD cases (78.6%) had minor cutaneous changes and almost half of cases (41.7%) had refluxes only in tributaries, significant differences in symptom improvement in CVD-dominant group suggested that early-stage venous reflux is a symptomatic disease and a possible cause of leg pain and other symptoms.
Multi-mode joint modulation of array wireless power transfer
Authors: Li Da , Wu Xusheng , Gao Wei , Gao Jianxin
Published: July 2023

In this paper, an array multi-mode wireless power transfer system for UAV is proposed. The system realizes the joint modulation of a single transmitting coil, double transmitting coil, and four transmitting coils in the array wireless power transmission system through PI closed-loop control and realizes the stable output of the WPT system in three different working modes. It effectively compensates for the shortcomings of the single transmitter coil and effectively improves the robustness of the wireless power transfer system.
His1-tagged DM or DDM detergent micelles are reversibly conjugated by nickel ions
Authors: Lal Mitra , Wachtel Ellen , Pati Soumyaranjan , Namboothiri Irishi. N. N. , Patchornik Guy
Published: July 2023

Specific conjugation of decyl β-D-maltoside (DM) or dodecyl β-D-maltoside (DDM) detergent micelles is accomplished between pH 7.0-8.5 in the presence of an amphiphilic analog of the amino acid histidine, bound to a 10-carbon hydrocarbon chain (His1-C10) and Ni2+ ions. Following addition of 10–15 wt% PEG-6000 as precipitant, phase separation in the form of oil-rich globules (30–600 µm) is observed by light microscopy. Other divalent cations: Zn2+, Fe2+, Cu2+ lead to dark precipitates rather than colorless globules; while Mg2+, Ca2+ do not promote any phase separation at all. Even in the absence of precipitant, dynamic light scattering (DLS) measurements demonstrate that DM micelles (hydrodynamic size ~ 6 nm) or DDM micelles (8 nm) self-associate into larger particles (9 nm and 411 nm for DM; 10 nm and 982 nm for DDM) in the presence of His1-C10 and nickel ions. Micellar conjugation is partially reversible in the presence of water soluble 50 mM EDTA, histidine or imidazole chelators. Cryo-transmission electron microscopy (cryo-TEM) imaging revealed the formation of non-uniformly dense detergent aggregates for both DM and DDM micelles in the presence of precipitant. The possible utility of such His1-tagged DM or DDM micelles for promoting crystallization of integral membrane proteins is discussed.
Localization of NPY Immunoreactivity in the Proximal and Distal Intestinal Region of Teleost Fish, Notopterus
Authors: Khadse Tulika A.
Published: July 2023

The purpose of the present study was to investigate the immunocytochemical aspects of the intestine of the teleost fish Notopterus notopterus. The distribution and relative frequency of the endocrine cells in the intestine were studied immunocytochemically using Streptavidin biotin peroxidase complex method. The aim was analyse the distribution and localization of immunoreactivity in the intestine of Notopterus notopterus against the antisera NPY. The samples were taken from the proximal and distal intestine. The NPY immunoreactive endocrine cells were found in the distal intestine at low frequencies than proximal intestine. These immunoreactive cells were distributed among more in mucosa epithelium and very low in the lamina propria and submucosa of intestine of N.notopterus.
Effects of Combinational Use of Additional Differential Diagnostic Generators on the Diagnostic Accuracy of the Differential Diagnosis List Developed by an Artificial Intelligence–Driven Automated History–Taking System: Pilot Cross-Sectional Study
Authors: Harada Yukinori , Tomiyama Shusaku , Sakamoto Tetsu , Sugimoto Shu , Kawamura Ren , Yokose Masashi , Hayashi Arisa , Shimizu Taro
Published: July 2023

Background

Low diagnostic accuracy is a major concern in automated medical history–taking systems with differential diagnosis (DDx) generators. Extending the concept of collective intelligence to the field of DDx generators such that the accuracy of judgment becomes higher when accepting an integrated diagnosis list from multiple people than when accepting a diagnosis list from a single person may be a possible solution.

Objective

The purpose of this study is to assess whether the combined use of several DDx generators improves the diagnostic accuracy of DDx lists.

Methods

We used medical history data and the top 10 DDx lists (index DDx lists) generated by an artificial intelligence (AI)–driven automated medical history–taking system from 103 patients with confirmed diagnoses. Two research physicians independently created the other top 10 DDx lists (second and third DDx lists) per case by imputing key information into the other 2 DDx generators based on the medical history generated by the automated medical history–taking system without reading the index lists generated by the automated medical history–taking system. We used the McNemar test to assess the improvement in diagnostic accuracy from the index DDx lists to the three types of combined DDx lists: (1) simply combining DDx lists from the index, second, and third lists; (2) creating a new top 10 DDx list using a 1/n weighting rule; and (3) creating new lists with only shared diagnoses among DDx lists from the index, second, and third lists. We treated the data generated by 2 research physicians from the same patient as independent cases. Therefore, the number of cases included in analyses in the case using 2 additional lists was 206 (103 cases × 2 physicians’ input).

Results

The diagnostic accuracy of the index lists was 46% (47/103). Diagnostic accuracy was improved by simply combining the other 2 DDx lists (133/206, 65%, P<.001), whereas the other 2 combined DDx lists did not improve the diagnostic accuracy of the DDx lists (106/206, 52%, P=.05 in the collective list with the 1/n weighting rule and 29/206, 14%, P<.001 in the only shared diagnoses among the 3 DDx lists).

Conclusions

Simply adding each of the top 10 DDx lists from additional DDx generators increased the diagnostic accuracy of the DDx list by approximately 20%, suggesting that the combinational use of DDx generators early in the diagnostic process is beneficial.
Economic Activity of Older People in Selected EU Countries
Authors: Wasilewska Ewa
Published: July 2023

The paper presents an analysis of changes in activity of the population in older age people (50-64 years) in selected EU countries: Finland, Germany, the Netherlands and Estonia in the context of demographic aging. The study period covered the years 2000 to 2012. It was low participation of people aged 50+ in most European countries and the EU average. At the same time there was an increase in the labor market involvement of people in this age group in recent years. Also presented are examples of good practices used in those countries that have successfully improved the situation on the labor market, leading to an increase in employment of people around the age of retirement.
The efforts of the Madrasah Principal to Improve the Quality of Islamic Education Post of the Natural Disaster in Palu City
Authors: Risman Risman , S. Pettalongi Sagaf , Saude Saude
Published: July 2023

This research discusses the efforts of the madrasah principal to improve the quality of Islamic education after the 2018 disaster. This research aims to examine the actions of the madrasah principal in improving the quality of Islamic education and identify the supporting and inhibiting factors faced by the madrasah principal in improving the quality of Islamic education after the 2018 natural disaster. This research uses a qualitative method with a descriptive approach. The study was conducted at State Islamic Senior High School 1 Palu. Data were collected through direct observation, in-depth interviews, and written documents. The results of this research show that the efforts made by the madrasah principal in improving the quality of Islamic education after the natural disaster include improving the quality of education and teaching, collaborating in the field of human resources, implementing education following the madrasah's vision and mission, maximizing the use of existing facilities and infrastructure, and proposing the construction of a building to the government and donors. Several factors that support the madrasah principal's efforts include the collaboration between the madrasah principal, teachers, educational staff, parents, and the community in achieving the goals of the madrasah principal.