bluuebunny/crossref_metadata_2025 huggingface dataset:
Cell Proliferation and Apoptosis—Key Players in the Lung Aging Process
Authors: Ancer-Rodríguez Jesús , Gopar-Cuevas Yareth , García-Aguilar Karol , Chávez-Briones María-de-Lourdes , Miranda-Maldonado Ivett , Ancer-Arellano Adriana , Ortega-Martínez Marta , Jaramillo-Rangel Gilberto
Published: July 2024

Currently, the global lifespan has increased, resulting in a higher proportion of the population over 65 years. Changes that occur in the lung during aging increase the risk of developing acute and chronic lung diseases, such as acute respiratory distress syndrome, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, and lung cancer. During normal tissue homeostasis, cell proliferation and apoptosis create a dynamic balance that constitutes the physiological cell turnover. In basal conditions, the lungs have a low rate of cell turnover compared to other organs. During aging, changes in the rate of cell turnover in the lung are observed. In this work, we review the literature that evaluates the role of molecules involved in cell proliferation and apoptosis in lung aging and in the development of age-related lung diseases. The list of molecules that regulate cell proliferation, apoptosis, or both processes in lung aging includes TNC, FOXM1, DNA-PKcs, MicroRNAs, BCL-W, BCL-XL, TCF21, p16, NOX4, NRF2, MDM4, RPIA, DHEA, and MMP28. However, despite the studies carried out to date, the complete signaling pathways that regulate cell turnover in lung aging are still unknown. More research is needed to understand the changes that lead to the development of age-related lung diseases.
Flavonoids-Enriched Vegetal Extract Prevents the Activation of NFκB Downstream Mechanisms in a Bowel Disease In Vitro Model
Authors: Corbetta Paolo , Lonati Elena , Pagliari Stefania , Mauri Mario , Cazzaniga Emanuela , Botto Laura , Campone Luca , Palestini Paola , Bulbarelli Alessandra
Published: July 2024

Inflammatory bowel disease (IBD) incidence has increased in the last decades due to changes in dietary habits. IBDs are characterized by intestinal epithelial barrier disruption, increased inflammatory mediator production and excessive tissue injury. Since the current treatments are not sufficient to achieve and maintain remission, complementary and alternative medicine (CAM) becomes a primary practice as a co-adjuvant for the therapy. Thus, the intake of functional food enriched in vegetal extracts represents a promising nutritional strategy. This study evaluates the anti-inflammatory effects of artichoke, caihua and fenugreek vegetal extract original blend (ACFB) in an in vitro model of gut barrier mimicking the early acute phases of the disease. Caco2 cells cultured on transwell supports were treated with digested ACFB before exposure to pro-inflammatory cytokines. The pre-treatment counteracts the increase in barrier permeability induced by the inflammatory stimulus, as demonstrated by the evaluation of TEER and CLDN-2 parameters. In parallel, ACFB reduces p65NF-κB pro-inflammatory pathway activation that results in the decrement of COX-2 expression as PGE2 and IL-8 secretion. ACFB properties might be due to the synergistic effects of different flavonoids, indicating it as a valid candidate for new formulation in the prevention/mitigation of non-communicable diseases.
Sulforaphane Effects on Neuronal-like Cells and Peripheral Blood Mononuclear Cells Exposed to 2.45 GHz Electromagnetic Radiation
Authors: Bertuccio Maria Paola , Saija Caterina , Acri Giuseppe , Ientile Riccardo , Caccamo Daniela , Currò Monica
Published: July 2024

Exposure to 2.45 GHz electromagnetic radiation (EMR) emitted from commonly used devices has been reported to induce oxidative stress in several experimental models. Our study aims to evaluate the efficacy of sulforaphane, a well-known natural product, in preventing radiation-induced toxic effects caused by a 24 h exposure of SH-SY5Y neuronal-like cells and peripheral blood mononuclear cells (PBMCs) to 2.45 GHz EMR. Cells were exposed to radiation for 24 h in the presence or absence of sulforaphane at different concentrations (5–10–25 µg/mL). Cell viability, mitochondrial activity alterations, the transcription and protein levels of redox markers, and apoptosis-related genes were investigated. Our data showed a reduction in cell viability of both neuronal-like cells and PBMCs caused by EMR exposure and a protective effect of 5 µg/mL sulforaphane. The lowest sulforaphane concentration decreased ROS production and increased the Mitochondrial Transmembrane Potential (Δψm) and the NAD+/NADH ratio, which were altered by radiation exposure. Sulforaphane at higher concentrations displayed harmful effects. The hormetic behavior of sulforaphane was also evident after evaluating the expression of genes coding for Nrf2, SOD2, and changes in apoptosis markers. Our study underlined the vulnerability of neuronal-like cells to mitochondrial dysfunction and oxidative stress and the possibility of mitigating these effects by supplementation with sulforaphane. To our knowledge, there are no previous studies about the effects of SFN on these cells when exposed to 2.45 GHz electromagnetic radiation.
Photocatalytic Degradation of Organic Dyes by Magnetite Nanoparticles Prepared by Co-Precipitation
Authors: Mbuyazi Thandi B. , Ajibade Peter A.
Published: July 2024

Iron oxide nanoparticles were synthesized by co-precipitation using three different iron salt stoichiometric mole ratios. Powder X-ray diffraction patterns revealed the inverse cubic spinel structure of magnetite iron oxide. Transmission electron microscopic images showed Fe3O4 nanoparticles with different shapes and average particle sizes of 5.48 nm for Fe3O4-1:2, 6.02 nm for Fe3O4-1.5:2, and 6.98 nm for Fe3O4-2:3 with an energy bandgap of 3.27 to 3.53 eV. The as-prepared Fe3O4 nanoparticles were used as photocatalysts to degrade brilliant green (BG), rhodamine B (RhB), indigo carmine (IC), and methyl red (MR) under visible light irradiation. The photocatalytic degradation efficiency of 80.4% was obtained from Fe3O4-1:2 for brilliant green, 61.5% from Fe3O4-1.5:2 for rhodamine B, and 77.9% and 73.9% from Fe3O4-2:3 for both indigo carmine and methyl red. This indicates that Fe3O4-2:3 is more efficient in the degradation of more than one dye. This study shows that brilliant green degrades most effectively at pH 9, rhodamine B degrades best at pH 6.5, and indigo carmine and methyl red degrade most efficiently at pH 3. Recyclability experiments showed that the Fe3O4 photocatalysts can be recycled four times and are photostable.
Temporal Evolution of Defects and Related Electric Properties in He-Irradiated YBa2Cu3O7−δ Thin Films
Authors: Keppert Sandra , Aichner Bernd , Rohringer Philip , Bodea Marius-Aurel , Müller Benedikt , Karrer Max , Kleiner Reinhold , Goldobin Edward , Koelle Dieter , Pedarnig Johannes D. , Lang Wolfgang
Published: July 2024

Thin films of the superconductor YBa2Cu3O7−δ (YBCO) were modified by low-energy light-ion irradiation employing collimated or focused He+ beams, and the long-term stability of irradiation-induced defects was investigated. For films irradiated with collimated beams, the resistance was measured in situ during and after irradiation and analyzed using a phenomenological model. The formation and stability of irradiation-induced defects are highly influenced by temperature. Thermal annealing experiments conducted in an Ar atmosphere at various temperatures demonstrated a decrease in resistivity and allowed us to determine diffusion coefficients and the activation energy ΔE=(0.31±0.03) eV for diffusive oxygen rearrangement within the YBCO unit cell basal plane. Additionally, thin YBCO films, nanostructured by focused He+-beam irradiation into vortex pinning arrays, displayed significant commensurability effects in magnetic fields. Despite the strong modulation of defect densities in these pinning arrays, oxygen diffusion during room-temperature annealing over almost six years did not compromise the signatures of vortex matching, which remained precisely at their magnetic fields predicted by the pattern geometry. Moreover, the critical current increased substantially within the entire magnetic field range after long-term storage in dry air. These findings underscore the potential of ion irradiation in tailoring the superconducting properties of thin YBCO films.
Effects of SRI-32743, a Novel Quinazoline Structure-Based Compound, on HIV-1 Tat and Cocaine Interaction with Norepinephrine Transporter
Authors: Jiménez-Torres Ana Catya , Porter Katherine D. , Hastie Jamison A. , Adeniran Charles , Moukha-Chafiq Omar , Nguyen Theresa H. , Ananthan Subramaniam , Augelli-Szafran Corinne E. , Zhan Chang-Guo , Zhu Jun
Published: July 2024

Prolonged exposure to HIV-1 transactivator of transcription (Tat) protein dysregulates monoamine transmission, a physiological change implicated as a key factor in promoting neurocognitive disorders among people living with HIV. We have demonstrated that in vivo expression of Tat in Tat transgenic mice decreases dopamine uptake through both dopamine transporter (DAT) and norepinephrine transporter (NET) in the prefrontal cortex. Further, our novel allosteric inhibitor of monoamine transporters, SRI-32743, has been shown to attenuate Tat-inhibited dopamine transport through DAT and alleviates Tat-potentiated cognitive impairments. The current study reports the pharmacological profiles of SRI-32743 in basal and Tat-induced inhibition of human NET (hNET) function. SRI-32743 exhibited less affinity for hNET binding than desipramine, a classical NET inhibitor, but displayed similar potency for inhibiting hDAT and hNET activity. SRI-32743 concentration-dependently increased hNET affinity for [3H]DA uptake but preserved the Vmax of dopamine transport. SRI-32743 slowed the cocaine-mediated dissociation of [3H]Nisoxetine binding and reduced both [3H]DA and [3H]MPP+ efflux but did not affect d-amphetamine-mediated [3H]DA release through hNET. Finally, we determined that SRI-32743 attenuated a recombinant Tat1–86-induced decrease in [3H]DA uptake via hNET. Our findings demonstrated that SRI-32743 allosterically disrupts the recombinant Tat1–86–hNET interaction, suggesting a potential treatment for HIV-infected individuals with concurrent cocaine abuse.
Therapeutic Potential of Mesenchymal Stem Cell-Derived Exosomes as Nanomedicine for Peripheral Nerve Injury
Authors: Li Qicheng , Zhang Fengshi , Fu Xiaoyang , Han Na
Published: July 2024

Peripheral nerve injury (PNI) is a complex and protracted process, and existing therapeutic approaches struggle to achieve effective nerve regeneration. Recent studies have shown that mesenchymal stem cells (MSCs) may be a pivotal choice for treating peripheral nerve injury. MSCs possess robust paracrine capabilities, and exosomes, as the primary secretome of MSCs, are considered crucial regulatory mediators involved in peripheral nerve regeneration. Exosomes, as nanocarriers, can transport various endogenous or exogenous bioactive substances to recipient cells, thereby promoting vascular and axonal regeneration while suppressing inflammation and pain. In this review, we summarize the mechanistic roles of exosomes derived from MSCs in peripheral nerve regeneration, discuss the engineering strategies for MSC-derived exosomes to improve therapeutic potential, and explore the combined effects of MSC-derived exosomes with biomaterials (nerve conduits, hydrogels) in peripheral nerve regeneration.
Nanoparticles and Airway Epithelial Cells: Exploring the Impacts and Methodologies in Toxicity Assessment
Authors: Lee Claire E. , Rezaee Fariba
Published: July 2024

The production of nanoparticles has recently surged due to their varied applications in the biomedical, pharmaceutical, textile, and electronic sectors. However, this rapid increase in nanoparticle manufacturing has raised concerns about environmental pollution, particularly its potential adverse effects on human health. Among the various concerns, inhalation exposure to nanoparticles poses significant risks, especially affecting the respiratory system. Airway epithelial cells play a crucial role as the primary defense against inhaled particulate matter and pathogens. Studies have shown that nanoparticles can disrupt the airway epithelial barrier, triggering inflammatory responses, generating reactive oxygen species, and compromising cell viability. However, our understanding of how different types of nanoparticles specifically impact the airway epithelial barrier remains limited. Both in vitro cell culture and in vivo murine models are commonly utilized to investigate nanoparticle-induced cellular responses and barrier dysfunction. This review discusses the methodologies frequently employed to assess nanoparticle toxicity and barrier disruption. Furthermore, we analyze and compare the distinct effects of various nanoparticle types on the airway epithelial barrier. By elucidating the diverse responses elicited by different nanoparticles, we aim to provide insights that can guide future research endeavors in assessing and mitigating the potential risks associated with nanoparticle exposure.
Performance of Flow Cytometry-Based Rapid Assay in Detection of Carbapenemase-Producing Enterobacterales
Authors: Pérez-Viso Blanca , Martins-Oliveira Inês , Gomes Rosário , Silva-Dias Ana , Peixe Luísa , Novais Ângela , Pina-Vaz Cidália , Cantón Rafael
Published: July 2024

Carbapenemase-producing Enterobacterales are increasingly being recognized in nosocomial infections. The performance of a flow cytometry-based rapid assay for their detection and differentiation was evaluated. This is a disruptive phenotypic technology, phenotypic and growth-independent, that searches for the lesions produced by drugs acting on cells after a short incubation time. Overall, 180 Gram-negative bacteria were studied, and results were compared with those obtained molecularly by PCR and phenotypically by ‘KPC, MBL and OXA-48 Confirm Kit’. This phenotypic method was used as reference for comparison purposes. Susceptibility to carbapenems (imipenem, meropenem, and ertapenem) was determined by standard broth microdilution. Overall, 112 isolates (62.2%) were carbapenemase producers, 41 KPCs, 36 MβLs, and 31 OXA-48, and 4 strains were KPC + MβL co-producers. Sixty-eight isolates were carbapenemase-negative. The percentage of agreement, sensitivity, and specificity were calculated according to ISO 20776-2:2021. The FASTinov assay showed 97.7% agreement with the reference method for carbapenemase detection. Discrepant flow cytometry results were obtained in four isolates compared with both reference and PCR results. The sensitivity and specificity of this new technology were 95.3% and 98.5%, respectively, for KPCs, 97.6% and 99.3% for MβLs, and 96.9% and 98% for OXA-48 detection. In conclusion, we describe a rapid flow cytometry assay with high accuracy for carbapenemase detection and the differentiation of various carbapenemases, which should impact clinical microbiology laboratories and patient management.
Machine Learning Applied to the Analysis of Prolonged COVID Symptoms: An Analytical Review
Authors: Ariza-Colpas Paola Patricia , Piñeres-Melo Marlon Alberto , Urina-Triana Miguel Alberto , Barceló-Martinez Ernesto , Barceló-Castellanos Camilo , Roman Fabian
Published: July 2024

The COVID-19 pandemic continues to constitute a public health emergency of international importance, although the state of emergency declaration has indeed been terminated worldwide, many people continue to be infected and present different symptoms associated with the illness. Undoubtedly, solutions based on divergent technologies such as machine learning have made great contributions to the understanding, identification, and treatment of the disease. Due to the sudden appearance of this virus, many works have been carried out by the scientific community to support the detection and treatment processes, which has generated numerous publications, making it difficult to identify the status of current research and future contributions that can continue to be generated around this problem that is still valid among us. To address this problem, this article shows the result of a scientometric analysis, which allows the identification of the various contributions that have been generated from the line of automatic learning for the monitoring and treatment of symptoms associated with this pathology. The methodology for the development of this analysis was carried out through the implementation of two phases: in the first phase, a scientometric analysis was carried out, where the countries, authors, and magazines with the greatest production associated with this subject can be identified, later in the second phase, the contributions based on the use of the Tree of Knowledge metaphor are identified. The main concepts identified in this review are related to symptoms, implemented algorithms, and the impact of applications. These results provide relevant information for researchers in the field in the search for new solutions or the application of existing ones for the treatment of still-existing symptoms of COVID-19.
Crystal Structure and Anti-Proliferative and Mutagenic Evaluation of the Palladium(II) Complex of Deoxyalliin
Authors: Candido Tuany Zambroti , Quintanilha Mariana Mazzo , Schimitd Bianca Alves , Simoni Déborah de Alencar , Nakahata Douglas Hideki , de Paiva Raphael Enoque Ferraz , Cerqueira Igor Henrique , Resende Flávia Aparecida , Carvalho João Ernesto , Ruiz Ana Lucia Tasca Gois , Lima Carmen Silvia Passos , Corbi Pedro Paulo
Published: July 2024

Platinum(II) and palladium(II) complexes have been investigated as potential anticancer drugs since the serendipitous discovery of the antineoplastic activities of cisplatin in the 1960s. Skin cancer is considered the most common malignant neoplasm that affects humans, and melanoma is the most lethal type of skin cancer. Surgical excision is the main form of treatment, which also may include radiotherapy, systemic chemotherapy, and immunotherapy. In this work, new insights concerning the structural characterization and in vitro anti-proliferative activity of the palladium(II) complex with the amino acid deoxyalliin (Pd-sac) against a panel of thirteen human tumor cells, with emphasis on skin cancer cell lines, are presented. The composition of the complex was confirmed by elemental analysis as [Pd(C6H10NO2S)2]. The structure of the complex was elucidated for the first time by a single-crystal X-ray diffraction technique. Each deoxyalliin molecule coordinates in a bidentate N,S-mode to palladium(II) in a trans-configuration analogous to the platinum(II) deoxyalliin complex early reported. As the main result, the Pd-sac complex showed a selective anti-proliferative activity against melanoma (UACC-62, TGI = 63.5 µM), while both deoxyalliin and K2PdCl4 were inactive against all cell lines. Moreover, Pd-sac did not affect the proliferation of non-tumorigenic keratinocytes (HaCaT, TGI > 586 µM) and was non-mutagenic in the Ames assay. The results open new perspectives for in vivo studies concerning the application of the Pd-sac complex in the treatment of melanoma.
La2C2@D5(450)-C100: Calculated High Energy Gain in Encapsulation
Authors: Slanina Zdeněk , Uhlík Filip , Akasaka Takeshi , Lu Xing , Adamowicz Ludwik
Published: July 2024

The structure and energetics of the clusterfullerene La2C2@D5(450)-C100 are calculated at the B3LYP/6-31G*∼SDD level (including counterpoise correction for the basis set superposition error), and the observed features are confirmed. Its stability is explained by substantial energy gain connected with the encapsulation, viz. 140 kcal/mol per atom of the encapsulate, actually higher than previously found for comparable systems.
Corporate Finance and Environmental, Social, and Governance (ESG) Practices
Authors: Gherghina Ștefan Cristian
Published: July 2024

As global warming progresses, implementing green finance to redirect resources into sustainable initiatives has emerged as a crucial strategy for governments to develop financial systems that are carbon-free, green, and sustainable (Jin et al [...]
Probability Prediction of Curing Process-Induced Deformation for V-Shape Composite Structures Based on FEM Method and Data Mining
Authors: Feng Guangshuo , Liu Bo
Published: July 2024

Continuous fiber-reinforced composites are increasingly used in industry for their superior specific modulus and strength. The curing process-induced deformation (PID) has been a critical problem during manufacturing, which always exhibits dispersed values even if the curing process curve and structural parameters remain consistent. This work conducted probability prediction of PID for V-shape composite structures based on the FEM method and data mining. A sequential coupling thermal–chemical–mechanical coupling FE model is established in ABAQUS. The prediction accuracy of the included angle between two sides is verified by the experimental results. Material parameter uncertainties are considered for V-shape structures with different radii and thicknesses. Based on the dataset from the FE model, a decision tree is established and trained to analyze the sensitivity and to predict the probability distribution of PID. The results show that PID increases with the coefficients of thermal expansion in the in-plane perpendicular fiber direction and out-of-plane normal direction. The data-mining method is accurate enough for the PID prediction, and its efficiency provides an additional calculation option in engineering applications.
Peculiarities of Electric and Dielectric Behavior of Ni- or Fe-Doped ZnO Thin Films Deposited by Atomic Layer Deposition
Authors: Paskaleva Albena , Spassov Dencho , Blagoev Blagoy , Terziyska Penka
Published: July 2024

The physical properties of ZnO can be tuned efficiently and controllably by doping with the proper element. Doping of ZnO thin films with 3D transition metals that have unpaired electron spins (e.g., Fe, Co, Ni, etc.) is of particular interest as it may enable magnetic phenomena in the layers. Atomic layer deposition (ALD) is the most advanced technique, which ensures high accuracy throughout the deposition process, producing uniform films with controllable composition and thickness, forming smooth and sharp interfaces. In this work, ALD was used to prepare Ni- or Fe-doped ZnO thin films. The dielectric and electrical properties of the films were studied by measuring the standard current–voltage (I–V), capacitance–voltage (C–V), and capacitance–frequency (C–f) characteristics at different temperatures. Spectral ellipsometry was used to assess the optical bandgap of the layers. We established that the dopant strongly affects the electric and dielectric behavior of the layers. The results provide evidence that different polarization mechanisms dominate the dielectric response of Ni- and Fe-doped films.
In Situ Growth Method for Large-Area Flexible Perovskite Nanocrystal Films
Authors: Zhou Xingting , Xu Bin , Zhao Xue , Lv Hongyu , Qiao Dongyang , Peng Xing , Shi Feng , Chen Menglu , Hao Qun
Published: July 2024

Metal halide perovskites have shown unique advantages compared with traditional optoelectronic materials. Currently, perovskite films are commonly produced by either multi-step spin coating or vapor deposition techniques. However, both methods face challenges regarding large-scale production. Herein, we propose a straightforward in situ growth method for the fabrication of CsPbBr3 nanocrystal films. The films cover an area over 5.5 cm × 5.5 cm, with precise thickness control of a few microns and decent uniformity. Moreover, we demonstrate that the incorporation of magnesium ions into the perovskite enhances crystallization and effectively passivates surface defects, thereby further enhancing luminous efficiency. By integrating this approach with a silicon photodiode detector, we observe an increase in responsivity from 1.68 × 10−2 A/W to 3.72 × 10−2 A/W at a 365 nm ultraviolet wavelength.
Self-Healing Thermal-Reversible Low-Temperature Polyurethane Powder Coating Based on Diels–Alder Reaction
Authors: Pojnar Katarzyna , Pilch-Pitera Barbara , Ataei Shahla , Gazdowicz Patrycja , Mossety-Leszczak Beata , Grabowska Beata , Bobrowski Artur
Published: July 2024

This work focused on obtaining a low-temperature powder coating characterized by self-healing properties. To achieve this, acrylic resin, blocked polyisocyanates (bPICs) with 1,2,4-triazole, and unsaturated commercial resin were used. The synthesis of bPICs with triazole enabled the low-temperature curing and reversible Diels–Alder (DA) reaction at 160 °C. The chemical structure of bPICs was confirmed using 1H-NMR. The occurrence of the DA and retro-DA (rDA) reactions in the crosslinked polymer, at temperatures of 60–85 °C and 90–130 °C, respectively, was confirmed using Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA), and FT-IR spectroscopy. The self-healing properties of the powder coating were examined using polarized optical microscopy. Additionally, the occurrence of the DA and rDA reactions between triazole and unsaturated polyester resin was investigated through repeated self-healing tests.
Investigation of the Mechanical Strength of Artificial Metallic Mandibles with Lattice Structure for Mandibular Reconstruction
Authors: Kawamata Shinsuke , Kawai Tadashi , Yasuge Erika , Hoshi Isao , Minamino Tadaharu , Kurosu Shingo , Yamada Hiroyuki
Published: July 2024

Mandibular reconstructive surgery is necessary for large bone defects. Although various reconstruction methods have been performed clinically, there is no mandibular reconstruction method that meets both sufficient strength criteria and the patient’s specific morphology. In this study, the material strength of the cylindrical lattice structures formed by electron-beam melting additive manufacturing using titanium alloy powder was investigated for mandibular reconstruction. The virtual strengths of 28 lattice structures were compared using numerical material tests with finite element method software. Subsequently, to compare the material properties of the selected structures from the preliminary tests, compression test, static bending test and fatigue test were conducted. The results showed that there were correlations with relative density and significant differences among the various structures when comparing internal stress with deformation, although there was a possibility of localized stress concentration and non-uniform stress distribution based on the lattice structure characteristics. These results suggest that the lattice structure of body diagonals with nodes and a cell size of 3.0 mm is a potential candidate for metallic artificial mandibles in mandibular reconstruction surgery.
Study on Expansion Rate of Steel Slag Cement-Stabilized Macadam Based on BP Neural Network
Authors: Wu Hengyu , Xu Feng , Li Bingyang , Gao Qiju
Published: July 2024

The physicochemical properties of steel slag were investigated using SEM and IR, and it was found that free calcium oxide and free magnesium oxide in steel slag produce calcium hydroxide when in contact with water, leading to volume expansion. Thus, the expansion rate of steel slag itself was first investigated, and it was found that the volume expansion of steel slag was more obvious in seven days after water immersion. Then, the cement dosages of 5% and 6% of the steel slag expansion rate and cement-stabilized gravel volume changes between the intrinsic link were further explored after the study found that the cement bonding effect can be partially inhibited due to the volume of expansion caused by the steel slag, so it can be seen that increasing the dosage of cement can reduce the volume expansion of steel slag cement-stabilized gravel with the same dosage of steel slag. Finally, a prediction model of the expansion rate of steel slag cement-stabilized gravel based on the BP (back propagation) neural network was established, which was verified to be a reliable basis for predicting the expansion rate of steel slag cement-stabilized aggregates and improving the accuracy of the proportioning design.
Research on the Influence of HMFI and PWHT Treatments on the Properties and Stress States of MAG-Welded S690QL Steel Joints
Authors: Górka Jacek , Przybyła Mateusz
Published: July 2024

The aim of this study was to analyze the effect of the HFMI (high-frequency mechanical impact) treatment of each weld bead on the properties of a butt joint with a ceramic backing welded by robotic method 135 (MAG—metal active gas welding method) and to determine the effect of HMFI on the stress level. This analysis was based on a comparison of three butt joints made of a S690QL plate, in the as-welded condition, with the HFMI of each bead and with the heat treatment carried out with PWHT stress relief annealing. The high-frequency (90 Hz) peening of each weld bead was linked with a stress reduction in the weld via the implementation of compressive stresses into the joint. The HFMI pneumatic hammer was used for this. The correctness of treatment was achieved when 100% of the surface of each bead including the face was treated. As part of the post-welding tests, basic tests were carried out based on the standards for the qualification of welding technology, and as a supplementary test, a stress state analysis using the Barkhausen effect was carried out. The tests carried out showed that the use of high-frequency peening after each pass did not affect the negative results of all the required tests when qualifying the welding technology of S690QL sheet metal compared to the test plates in the as-welded condition and after heat treatment—stress relief annealing. Inter-pass peening of the welded face and HAZ (heat-affected zone) resulted in a reduction in post-weld residual stresses at a distance of 12 mm from the joint axis compared to the stress measurement result for the sample in the as-welded condition. This allowed for a positive assessment of peening in the context of reducing the notch, which is the concentration of tensile stresses in the area of the fusion line and HAZ. The tests carried out showed that the peening process does not reduce the strength properties of welded joints, and the results obtained allow the technology to be qualified based on applicable standards.
Investigation into Effects of Coating on Stress Corrosion of Cable Bolts in Deep Underground Environments
Authors: Wu Saisai , Zhang Wanyi , Chen Jianhang , Skrzypkowski Krzysztof , Zagórski Krzysztof , Zagórska Anna
Published: July 2024

Due to the intricate and volatile nature of the service environment surrounding prestressing anchoring materials, stress corrosion poses a significant challenge to the sustained stability of underground reinforcement systems. Consequently, it is imperative to identify effective countermeasures against stress corrosion failure in cable bolts within deep underground environments, thereby ensuring the safety of deep resource extraction processes. In this study, the influence of various coatings on the stress corrosion resistance of cable bolts was meticulously examined and evaluated using specifically designed stress-corrosion-testing systems. The specimens were subjected to loading using four-point bending frames and exposed to simulated underground corrosive environments. A detailed analysis and comparison of the failure patterns and mechanisms of specimens coated with different materials were conducted through the meticulous observation of fractographic features. The results revealed stark differences in the stress corrosion behavior of coated and uncoated bolts. Notably, epoxy coatings and chlorinated rubber coatings exhibited superior anti-corrosion capabilities. Conversely, galvanized layers demonstrated the weakest effect due to their sacrificial anti-corrosion mechanism. Furthermore, the effectiveness of the coatings was found to be closely linked to the curing agent and additives used. The findings provide valuable insights for the design and selection of coatings that can enhance the durability and reliability of cable bolts in deep underground environments.
Mechanical Properties and Microscopic Study of Recycled Fibre Concrete Based on Wind Turbine Blades
Authors: Wang Jiajing , Wang Chenghao , Ji Yongcheng , Qie Ruihang , Wang Dayang , Liu Guanxun
Published: July 2024

In recent years, wind energy has begun to receive a significant amount of attention as clean energy is utilised and demanded in large quantities, resulting in a sharp increase in the use of wind turbines. The demand for wind turbines has gradually risen due to the clean and recyclable nature of wind energy. The current blade life of wind turbines in China is about 20 years, which means that the disposal of obsolete used blades can become a difficult problem in the future. Therefore, this study is of great significance to explore the regeneration performance of the blades after recycling and disposal. In this paper, wind turbine blades were mechanically recycled into recycled macrofibres, which were added to concrete as a reinforcing material to make wind impeller fibre concrete (WIC), and the three proportion ratios of 1%, 1.5%, and 2% were explored to compare the performance. The performance of WIC was also evaluated and its performance was compared to that of glass fibre concrete (GC). In addition, the material physical properties of second-generation recycled aggregate concrete (RAC) based on WIC were explored. The strength and peak strain variations and their causal mechanisms were analysed both macroscopically and microscopically by means of the classical mechanical tests (compression and bending tests), SEM, and XRD. The results show that the compressive strength of WIC was negatively correlated with the fibre content and increased by 6.04–18.12% compared to that of ordinary concrete (OG), with a maximum of 19.25 MPa; the flexural strength was positively correlated with the fibre content, with an increase of 5.37–18.5%. The microstructural analysis confirmed the macroscopic results and the intrinsic model better validated the experimental results.
Extending Multi-Output Methods for Long-Term Aboveground Biomass Time Series Forecasting Using Convolutional Neural Networks
Authors: Noa-Yarasca Efrain , Osorio Leyton Javier M. , Angerer Jay P.
Published: July 2024

Accurate aboveground vegetation biomass forecasting is essential for livestock management, climate impact assessments, and ecosystem health. While artificial intelligence (AI) techniques have advanced time series forecasting, a research gap in predicting aboveground biomass time series beyond single values persists. This study introduces RECMO and DirRecMO, two multi-output methods for forecasting aboveground vegetation biomass. Using convolutional neural networks, their efficacy is evaluated across short-, medium-, and long-term horizons on six Kenyan grassland biomass datasets, and compared with that of existing single-output methods (Recursive, Direct, and DirRec) and multi-output methods (MIMO and DIRMO). The results indicate that single-output methods are superior for short-term predictions, while both single-output and multi-output methods exhibit a comparable effectiveness in long-term forecasts. RECMO and DirRecMO outperform established multi-output methods, demonstrating a promising potential for biomass forecasting. This study underscores the significant impact of multi-output size on forecast accuracy, highlighting the need for optimal size adjustments and showcasing the proposed methods’ flexibility in long-term forecasts. Short-term predictions show less significant differences among methods, complicating the identification of the best performer. However, clear distinctions emerge in medium- and long-term forecasts, underscoring the greater importance of method choice for long-term predictions. Moreover, as the forecast horizon extends, errors escalate across all methods, reflecting the challenges of predicting distant future periods. This study suggests advancing hybrid models (e.g., RECMO and DirRecMO) to improve extended horizon forecasting. Future research should enhance adaptability, investigate multi-output impacts, and conduct comparative studies across diverse domains, datasets, and AI algorithms for robust insights.
Numerical Study of Temperature Field and Melt Pool Properties during Electron Beam Selective Melting Process with Single Line and Multiple Line Scanning
Authors: An Zhibin , Wang Bo , Yu Minghao
Published: July 2024

Electron beam selective melting is a metal powder bed fusion additive manufacturing technology. In order to study the temperature field and melt pool changes of high Nb-TiAl electron beam selective melting on a single scan line and multi-scan lines. In this paper, two three-dimensional thermal-fluid models are established to simulate the evolution of the melt pool and temperature field at different electron beam scanning speeds under a single scan line and the evolution of the temperature field under multi-scan lines. The simulation results of a single scan line show that the length of the bath increases with the increase in the electron beam scanning speed, while the width and depth of the bath decrease with the increase in the speed. The scanning speed has a significant impact on the length and depth of the micro-bath, but the impact on the width is relatively small. The simulation results of multi-scan lines show that the preheating temperature has a greater influence on the melting temperature field, while the size of the scanning current has a smaller influence on the temperature field. The conclusion drawn from the results obtained through simulation is that the temperature during the preheating process must be strictly controlled, and the melting process speed must be appropriately set in order to obtain high-quality samples.
Cell-Death Metabolites from Cocconeis scutellum var. parva Identified by Integrating Bioactivity-Based Fractionation and Non-Targeted Metabolomic Approaches
Authors: Sanchez-Arcos Carlos , Mutalipassi Mirko , Zupo Valerio , von Elert Eric
Published: July 2024

Epiphytic diatoms growing in Mediterranean seagrass meadows, particularly those of the genus Cocconeis, are abundant and ecologically significant, even in naturally acidified environments. One intriguing aspect of some benthic diatoms is their production of an unidentified cell-death-promoting compound, which induces destruction of the androgenic gland in Hippolyte inermis Leach, 1816, a shrimp exhibiting protandric hermaphroditism, principally under normal environmental pH levels. The consumption of Cocconeis spp. by this shrimp is vital for maintaining the stability of its natural populations. Although many attempts have been made to reveal the identity of the apoptotic compound, it is still unknown. In this study, we strategically integrated a bioactivity-based fractionation, a metabolomic approach, and two different experimental avenues to identify potential apoptotic metabolites from Cocconeis scutellum var. parva responsible for the sex reversal in H. inermis. Our integrated analysis uncovered two potential candidate metabolites, one putatively identified as a lysophosphatidylglycerol (LPG) (16:1) and the other classified as a fatty acid ester. This is the first time LPG (16:1) has been reported in C. scutellum var. parva and associated with cell-death processes. These candidate metabolites mark substantial progress in elucidating the factors responsible for triggering the removal of the androgenic gland in the early post-larval phases of H. inermis.
Reply to Saleh, C. Comment on “Bažadona et al. The Interconnection between Carotid Intima–Media Thickness and Obesity: Anthropometric, Clinical and Biochemical Correlations. Medicina 2023, 59, 1512”
Authors: Bažadona Danira , Matovinović Martina , Krbot Skorić Magdalena , Grbavac Hrvoje , Belančić Andrej , Malojčić Branko
Published: July 2024

We would like to begin by expressing our gratitude for the interest shown in our research [...]
Isolation and Characterization of Escherichia coli from Brazilian Broilers
Authors: Pilati Giulia Von Tönnemann , Salles Gleidson Biasi Carvalho , Savi Beatriz Pereira , Dahmer Mariane , Muniz Eduardo Correa , Filho Vilmar Benetti , Elois Mariana Alves , Souza Doris Sobral Marques , Fongaro Gislaine
Published: July 2024

Avian pathogenic Escherichia coli (APEC) causes colibacillosis, one of the main diseases leading to economic losses in industrial poultry farming due to high morbidity and mortality and its role in the condemnation of chicken carcasses. This study aimed to isolate and characterize APEC obtained from necropsied chickens on Brazilian poultry farms. Samples from birds already necropsied by routine inspection were collected from 100 batches of broiler chickens from six Brazilian states between August and November 2021. Three femurs were collected per batch, and characteristic E. coli colonies were isolated on MacConkey agar and characterized by qualitative PCR for minimal predictive APEC genes, antimicrobial susceptibility testing, and whole genome sequencing to identify species, serogroups, virulence genes, and resistance genes. Phenotypic resistance indices revealed significant resistance to several antibiotics from different antimicrobial classes. The isolates harbored virulence genes linked to APEC pathogenicity, including adhesion, iron acquisition, serum resistance, and toxins. Aminoglycoside resistance genes were detected in 79.36% of isolates, 74.6% had sulfonamide resistance genes, 63.49% showed β-lactam resistance genes, and 49.2% possessed at least one tetracycline resistance gene. This study found a 58% prevalence of avian pathogenic E. coli in Brazilian poultry, with strains showing notable antimicrobial resistance to commonly used antibiotics.
Magnetic Hardening: Unveiling Magnetization Dynamics in Soft Magnetic Fe–Ni–B–Nb Thin Films at Cryogenic Temperatures
Authors: Masood Ansar , Belova Liubov , Ström Valter
Published: July 2024

Recent advancements in amorphous materials have opened new avenues for exploring unusual magnetic phenomena at the sub-nanometer scale. We investigate the phenomenon of low-temperature “magnetic hardening” in heterogeneous amorphous Fe–Ni–B–Nb thin films, revealing a complex interplay between microstructure and magnetism. Magnetization hysteresis measurements at cryogenic temperatures show a significant increase in coercivity (HC) below 25 K, challenging the conventional Random Anisotropy Model (RAM) in predicting magnetic responses at cryogenic temperatures. Heterogeneous films demonstrate a distinct behavior in field-cooled and zero-field-cooled temperature-dependent magnetizations at low temperatures, characterized by strong irreversibility. This suggests spin-glass-like features at low temperatures, which are attributed to exchange frustration in disordered interfacial regions. These regions hinder direct exchange coupling between magnetic entities, leading to magnetic hardening. This study enhances the understanding of how microstructural intricacies impact magnetic dynamics in heterogeneous amorphous thin films at cryogenic temperatures.
Medication Adherence in Adults with Chronic Diseases in Primary Healthcare: A Quality Improvement Project
Authors: Oliveira Claúdia Jorge , José Helena Maria Guerreiro , Costa Emília Isabel Martins Teixeira da
Published: July 2024

(1) Background: Medication adherence is influenced by a variety of intricate factors, presenting hurdles for nurses working to improve it among adults with chronic conditions. Pinpointing the reasons for non-adherence is crucial for customizing interventions. The objective of this quality improvement project was to improve medication adherence among adults with chronic diseases in primary healthcare by promoting evidence-based practices, identifying barriers and facilitators to compliance, and developing strategies to ensure optimal adherence through engaging the nursing team, enhancing knowledge, and evaluating the effectiveness of the implemented strategies. (2) Methods: This study was a quality improvement project that utilized the JBI Evidence Implementation framework, the Practical Application of Clinical Evidence System, and the Getting Research into Practice audit tool across three phases: (i) forming a project team and conducting a baseline audit, (ii) offering feedback via the GRiP tool, and (iii) conducting a follow-up audit to assess best practice outcomes. The study was conducted between September 2021 and March 2022 in the community care unit of Algarve Regional Health Administration, targeting adults with chronic illnesses. (3) Results: A total of 148 individuals were audited, including 8 nurses, 70 baseline patients, and 70 post-implementation patients. Initial compliance with key best practices was low, with several criteria at 0% compliance at baseline. Post-intervention, we observed significant improvements; compliance with key best practices improved dramatically, with many reaching 100%. Notable improvements included enhanced patient education on medication management, regular medication adherence assessments, and increased engagement of healthcare professionals in adherence activities. (4) Conclusions: This quality improvement project demonstrated that structured, evidence-based interventions could significantly enhance medication adherence among adults with chronic diseases. The success of the project highlights the potential of similar strategies to be applied broadly in primary healthcare settings to improve health outcomes.
Palliative Care Coordination Interventions for Caregivers of Community-Dwelling Individuals with Dementia: An Integrative Review
Authors: Layne Diana , Logan Ayaba , Lindell Kathleen
Published: July 2024

Alzheimer’s disease is a serious illness with a protracted caregiving experience; however, care coordination interventions often lack the inclusion of palliative care. The purpose of this integrative review is to identify and synthesize existing care coordination interventions that include palliative care for individuals with dementia and their caregivers living in community settings. The Whittemore and Knafl framework guided the review, with data analysis guided by the SELFIE framework domains. Study quality was assessed using the Mixed Methods Appraisal Tool, while the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines informed reporting results. Nine care coordination interventions involving family caregivers across eighteen publications were identified. Only a single intervention explicitly mentioned palliative care, while the remaining interventions included traditional palliative care components such as advance care planning, symptom management, and emotional support. Many of the identified interventions lacked theoretical grounding and were studied in non-representative, homogeneous samples. Further research is needed to understand the lived experiences of people with dementia and their caregivers to alleviate care coordination burden.