bluuebunny/crossref_metadata_2025 huggingface dataset:
Students perspectives on switching from online to face-to-face learning environments after the COVID-19 pandemic
Authors: Wahid Masyitha , Firdaus Firdaus , Amaliah Nur , Ariandi Ariandi , Firman Firman , Irfan M. , Puspita Sari Arlinda , Rizaldi Trias Jaya Putra Nurdin‬ Muhammad
Published: March 2023

After around two years of having online learning, students in the universities have to come back to face-to-face learning mode as it was before the pandemic. This setting also applied to the biology education study program of Universitas Sulawesi Barat. The current study investigated the students’ perspective on changing online to face-to-face learning after COVID-19. It is a qualitative descriptive study with nine students as respondents from the classes of 2019, 2020, and 2021. The instrument used was an interview guide consisting of indicators regarding online teaching and learning features, assessment, and interactions that students needed to experience in face-to-face settings but would like to. In addition, students' perceptions of the advantages and disadvantages of the shift from online to offline learning were also assessed. The data analysis was performed in three stages: data reduction, data display, and drawing a conclusion or data verification. The result showed that several things they would like to have as it was during online learning were (1) have electronic materials, online-games-based learning, and more time to complete the assignments, (2) get various types of assessments including via online platforms (3) to have online applications or media to discuss learning materials and submit assignments. (4) In addition, for the advantages, the practicums could be conducted in laboratories, they felt more concentrated during offline classes, and became more confident to apply IT skills during offline settings, while the disadvantages were feeling anxious and fear to interacting during offline class and trouble to listen to lecturers’ class while having masks. Overall, students feel face-to-face learning is way more effective and efficient but suggested blended learning as an interesting mode in the learning and teaching implementation.
RANCANG BANGUN SISTEM PEMANTAUAN PARAMETER LINGKUNGAN BERBASIS INTERNET OF THINGS (IoT) DI GUDANG PENYIMPANAN UNTUK PABRIK GULA
Authors: Telaumbanua Mareli , Yana Eka , Suharyatun Siti , Lanya Budianto , Wisnu Febryan Kusuma , Rahmawati Winda
Published: March 2023

Gula merupakan salah satu komoditas kebutuhan pokok. Proses produksi untuk menghasilkan gula di pabrik terdiri dari beberapa tahapan yaitu penggiingan, pemurnian, penguapan, kristalisasi,  pemisahan dan penyelesaian. Setelah itu, gula yang telah dikemas, disimpan dalam gudang sebelum di kirim ke pasar. Kondisi lingkungan gudang penyimpan gula harus sesuai dengan standar. Faktor lingkungan yang tidak sesuai, mampu merusak gula. Beberapa faktor lingkungan penting dalam gudang penyimpanan yaitu suhu, kelembaban, CO2, dan api. Ketersediaan alat ukur portable berbasis internet of things merupakan salah satu bentuk pengawasan keamanan pabrik gula di dalam gudang, sehingga gula yang disimpan tidak menggumpal, meleleh dan menjadi rusak. Tujuan dari penelitian ini adalah untuk membuat alat monitoring gudang pabrik gula menggunakan sistem internet of things (IoT). Alat monitoring ruang yang dibuat terdiri dari komponen utama Wemos D1 R2, sensor MQ-135 untuk deteksi CO2, sensor DHT22 untuk deteksi suhu dan kelembaban dan sensor api. Semua komponen disusun di dalam kotak elektronik berwarna hitam dengan ukuran 15 cm x 9,5 cm x 5 cm. Terdapat 5 alat yang digunakan dalam penelitian ini. Uji kinerja sistem meliputi, tingkat stabilitas, Reliabilitas, respon sistem, akurasi pengiriman data. perhitungan penggunaan daya listrik dan biaya operasional alat diukur dalam penelitian ini. Uji kinerja dilakukan selama 7 hari dengan jarak antar ruang 50-100 meter. Dari hasil uji kinerja, seluruh sistem telah bekerja stabil. Hasil pengujian dengan menggunakan Cronbach Alpha taraf 5% menunjukan alat 1 sampai 5 menghasilkan nilai reliabilitas tinggi. Rerata respon sistem ke 5 alat yaitu 8,28 detik. Rerata akurasi transmisi data dari 5 alat meliputi data suhu adalah 0,00124, kelembaban 0,00434, dan Nilai CO2 adalah 0,00678. Hasil uji kinerja menunjukkan bahwa alat telah bekerja dengan baik sesuai harapan.
Gotong Royong Reflection in The Content of GOTO Advertising at Youtube
Authors: Marta Rustono Farady , Angreani Natasia , Wijaya Mikhael , Kurniasari Nani , Amanda Mercedes
Published: March 2023

This research aims to understand the meaning of 'Gotong Royong' in GOTO's YouTube video by applying Hofstede's Cultural Dimensions. The world keeps on revolving and more technologies has appeared to make life in all aspects easier. GOTO is a newly merged tech giant of Gojek and Tokopedia as one of the most popular e-commerce in Indonesia. In order to be accepted by society, GOTO creates a creative ad with a philosophical message that not only aims to market their products but also to introduce 'Gotong Royong,' which is the culture of Indonesia. Through Philip Mayring, Qualitative Content Analysis helps us to explain the Hofstede six cultural dimensions through the mixture of visual and audio found in GOTO's. In order the emphasize the “Gotong Royong” culture, by using Philip Mayring Qualitative Content Analysis, the video was divided into parts that represent the audio and visual elements, GoTo's video tries to show a cultural message that is "Gotong Royong" which is the culture of Indonesia. This research found that GOTO implemented their 'Gotong Royong' motto and combined it with the goal of establishing GOTO, which is to increase the country's economic growth.
Islamic Education Teachers’ Adaptation in Digital Learning during the Covid-19 Pandemic
Authors: Aisha Sarah , Firdaus Ahmad Zuhdi , Mulyana Deddy
Published: March 2023

The Covid-19 pandemic has disrupted educational communication, as traditional teaching and learning have been replaced by online digital teaching and learning. Thus, teachers must adapt quickly to new technology to meet the lesson objectives and successfully deliver their lessons. This study explores teachers’ adaptation experience throughout the Covid-19 pandemic. Data was gathered in Mutiara Bunda Elementary School, an inclusive private school in Bandung with religious education at its core. In-depth interviews and introspection were conducted with four Islamic education teachers across grades. Thematic analysis was used to analyse the data. The findings revealed that teachers went through five overlapping stages: confusion, trial and error, capacity building, adaptation, and efforts to find new solutions. However, different challenges were faced by each teacher according to the grades they taught. Even though teachers had finally adapted and transformed the teaching and learning experience, traditional face-to-face communication was still preferred by 1st to 3rd-grade teachers to deliver the lessons effectively. Lack of the teachers’ IT skills to deliver the lessons to develop the students’ character, inexperience in online teaching, and the students’ low motivation to learn through the digital platform clearly constitute the main obstacle in this religious, educational process.
Será o Cão o Melhor Amigo da Criança?
Authors: Mota Marina , Henriques Ana Raquel , Sousa Jéssica , Martins Rosa , Neves Ana Margarida
Published: March 2023

Nos últimos anos, tem havido um interesse científico crescente no campo da interação homem-animal, e os resultados têm sugerido vários potenciais benefícios, tanto em adultos como em crianças. Os cães podem desempenhar um papel importante no desenvolvimento social, emocional e cognitivo das crianças. Brincar com o cão pode também contribuir para aumentar a atividade física das crianças melhorando a sua qualidade de vida.No entanto, é inegável que existem efeitos desfavoráveis ou riscos que devem ser considerados. As preocupações mais frequentemente referidas são alergia, asma e transmissão de doenças zoonóticas. Além disso, riscos tais como agressões e mordeduras também devem ser considerados. Tem estado a ser estudado se a idade de exposição ao cão pode influenciar o risco de doença alérgica, não existindo dados suficientes. Não há evidência que suporte a existência de espécies hipoalergénicas.O médico deve informar a família de todos os riscos e benefícios associados à posse de um cão, contribuindo para uma decisão parental informada e consciente. É também aconselhável selecionar cuidadosamente o cão, tendo em conta as suas características intrínsecas, nomeadamente a agressividade. Fatores como o tempo diário disponível, espaço adequado, prestadores de cuidados para períodos de ausência e disponibilidade económica também devem ser ponderados.
Geografias das Juventudes
Authors: Oliveira Victor Hugo Nedel , Simão Mário Pires , Claudino Sérgio , Gamalho Nola Patrícia , Turra Neto Nécio , Cassab Clarice , Severo Ricardo Gonçalves , Silva Joseli Maria , Santos Felipe Eduardo Melo dos , Cesar Tamires Regina Aguiar de Oliveira , Cavalcanti Lana de Souza , Barbosa Jorge Luiz
Published: March 2023

Nessa obra, “a agenda extensionista da universidade faz encontrar um campo científico como a Geografia - que se constitui como um conhecimento do espaço socialmente produzido - com os sujeitos concretos que produzem o espaço, neste caso, jovens, interpretados aqui como um grupo social que deve ser pensado em seu contexto espaço-temporal” (Mário Simão).
“Mais do que uma coletânea de capítulos, este livro é composto por um tecido comum a demonstrar que versar sobre os/as jovens é implicar-se com suas vidas. È traçar um mapa sempre provisório de seus momentos, movimentos e afetos” (Jorge Barbosa).
Memórias sobre si: deslocamentos pessoais, profissionais e acadêmicos de mestrandos/as do PROFEPT/IFAL Volume2
Authors: Israel Jackson , Almeida Roseany Maria Araujo de , Santos Pablo Rodrigo Moura , Macedo Elisabete Henrique Silva de , Moura Renata Alves , Maciel Filho Valdenor Carvalho , Lima Alysson Matias Lopes de , Lira Marco Aurélio Andrade , Homem Edinéia Alves , Melo José Carlos Pessôa de , Silva Adriana Rodrigues de Oliveira da , Lima Jeorge Venancio Santos de , Santos Verônica Ribeiro dos , Lima José Rubens Silva , Silva Josivaldo da , Beirouti Mayara Romeiro Lins , Castro Karine Miranda , Santana Marta Oliveira de , Ribeiro Ricardo Luís Alves de Oliveira , Rocha Renata Maria Wanderley da , Ferraz Edileuza Lima
Published: March 2023

O ato de narrar se configura como uma das mais tenras atividades humanas. Por meio dele, a humanidade cria e recria a sua realidade numa imbricação ?invencionista. Especificamente, a escrita sobre si, nesse caso, na esfera acadêmica, possibilita o contato e a ressignificação com as vivências escolares. Tal empreitada é compreendida desde o momento em que os autores/as se inseriram nos seus processos de escolarização na Educação Básica, passando pelos cursos de graduação, até as suas chegadas à pós-graduação stricto sensu. Há de se enfatizar que a escrita memorialística é uma atividade acadêmica relevante na medida em que significa os processos pelos quais passarão os sujeitos, tendo em vista os seus contatos iniciais nessa esfera de escolarização, em especial, no que tange a um mestrado de cunho profissional, como é o caso do ProfEPT, atualmente, o maior Mestrado Profissional no contexto brasileiro, que é ofertado por 40 Instituições Associadas (IA), e, entre elas, está o Instituto Federal de Educação, Ciências e Tecnologia de Alagoas (Ifal).
TENDÊNCIAS DA LITERATURA BRASILEIRA SOBRE A PREVENÇÃO DO CÂNCER DE COLO UTERINO: UMA REVISÃO INTEGRATIVA
Authors: Batista Andersânya Silva , Cursino Germana Barreto Gondim , Bessa Maria E P
Published: March 2023

Este estudo objetivou realizar uma revisão integrativa sobre prevenção de câncer de colo uterino na literatura brasileira. Para tanto, realizou-se um levantamento bibliográfico em agosto de 2013 na Biblioteca Virtual em Saúde, referentes aos anos de 2010 a 2013. Compuseram a amostra 10 artigos. Destes, quatro tratam da prevenção dessa neoplasia; dois trouxeram o diagnóstico para este câncer; dois discutem a avaliação do rastreamento, dois apresentam os fatores relacionados a não realização do exame preventivo e um a fatores relacionados à adesão da colpocitologia oncótica. A realização desta pesquisa contribui para a ampliação de sínteses do conhecimento científico nacional, o que subsidia a efetivação de impactos diretos nas ações que tem se desenvolvido no âmbito da prática da enfermagem.
"Contribuições e desafios da Iniciação Científica Júnior"
Authors: SILVA KENIA LEANDRO
Published: March 2023

O estudo da contribuição da Iniciação Cietífica Júnior (IC Jr) como estratégia do ensino de Ciências, que enseja alfabetização cietífica e desenvolvimento de habilidades cognitivas, realizou-se mediante pesquisa qualitativa, Estudo de Caso, do Programa de IC Jr de uma escola técnica localizada em Minas Gerais, Brasil, com doze estudantes de Química Industrial. A motivação veio da necessidade de ações didáticas transformadoras do papel do estudante, para ativo na sua aprendizagem. Para isso, aplicou-se o questionário CTS/VOSTS, adaptação de Canavarro (2000) e outro de autoria própria de habilidades cognitivas. Verificou-se em 65% dos estudantes uma visão realista de questões CTSA, e quanto ao desenvolvimento de habilidades 58% na totalidade das questões, concordaram fortemente que desenvolveram habilidades cognitivas de compreensão da natureza do trabalho científico e pensamento crítico.
Ecoética en la conservación de los ecosistemas de niebla
Authors: Abarca Francisco , Lizana Fabián
Published: March 2023

La crisis ecológica actual ha dejado de manifiesto la incapacidad del ser humano para contrarrestar los efectos devastadores de sus acciones en la naturaleza, evidenciando que gran parte de la responsabilidad se debe a un problema ético. De esta situación, resaltan los valores Ecoéticos como base de entendimiento para resignicar la relación entre el humano y el medio natural. El propósito de este escrito es aproximarse a una revalorización del paisaje desértico desde una mirada ecoética basándose en la resignificación filosófica de la relación ser humano-naturaleza, destacando la responsabilidad del ser humano como parte y miembro, dejando de lado su rol destructor postulado central de “la ética de la tierra” escrita por Aldo Leopold y que marca el inicio del debate sobre la ecoética y la conservación del medio ambiente, evidenciando la importancia ecológica del intercambio energético, viendo en ello, diferentes posturas epistemológicas y losócas sobre la relación ecológica del ser humano y su entorno.
Corporate Criminal Liability in Tax Crime: an Effort to Optimize State Revenue from The Tax Sector
Authors: Yoserwan Yoserwan
Published: March 2023

Tax crimes can be committed by taxpayers which include individuals as personal taxpayers and corporate taxpayers as taxable companies. The problem in the enforcement of tax criminal law is the unclear rules regarding corporate criminal liability in tax crimes. This article aims at discussing corporate criminal liability in tax crimes and its application in the investigation and prosecution process. The research uses normative legal research by collecting secondary data. They are primary legal sources and secondary legal sources. The results show that in handling tax crimes, both the investigators and prosecutors are doubtful to process the criminal liability of a corporation. The cause is the lack of clarity in the tax laws. As a result, criminal liability is just addressed to individual taxpayers as material perpetrators, even though the crime occurred within the scope of work of a corporation. Meanwhile, the corporation cannot be held criminally responsible. Thus, the shareholders, cannot also be held criminally responsible. Therefore, it is necessary to amend the current tax laws, so that a corporation can be prosecuted and punished for corporate crime. It is then expected that the compliance of corporations as the taxpayer will increase, and at the same time, tax evasion by corporations could be prevented. Finally, it is hoped that it will increase state revenue from the tax sector.
The Authority of Badan Penyelesaian Sengketa Konsumen (BPSK) and Tribunal Tuntutan Pengguna Malaysia (TTPM) in Consumer Dispute Resolution
Authors: Wahidi Ahmad , Mustaklima Mustaklima , Jannani Nur
Published: March 2023

The violation of consumer rights is the cause of disputes. Consumer disputes are defined as disputes between the consumers and business actors in which consumers demand compensation due to damage, pollution, and/ or because of consuming products sold by business actors. The existing conditions of Malaysian consumers, consumer dispute resolution in Malaysia and its regulations, which are undergoing improvements, are rational reasons for the subject of comparison. The purpose of this study is to explore the factors behind the success of consumer dispute resolution in Malaysia, in this case the Tribunal Tuntutan Pengguna Malaysia (TTPM) from the side of its authority that can be adopted in Indonesia to reconstruct the Badan Penyelesaian Sengketa Konsumen (BPSK) so that it can be more successful in resolve consumer disputes. The results show that TTPM’s authority is more specific on dispute resolution and only accepts claims with definite value limitations, while BPSK’s authority has no limitations on the value of claims, the limitation on the value of compensation is only in the provision of administrative sanctions to business actors, for parties (business actors) who do not comply with the BPSK decision, the BPSK decision is the initial evidence for carrying out an investigation regarding whether there was a crime in the non-compliance. Meanwhile, non-compliance with the TTPM decision has been considered a criminal act with criminal sanctions of imprisonment and fines.
Evaluation of Physical Stability of Phaleria Macrocarpa’s Leaf Extract Formulated in Nanoemulgel
Authors: Rosa Pratiwi  , Anggun Feranisa  , Elsa Yuliana Sukmawati
Published: March 2023

Background: Phaleria macrocarpa’s leaf contains alkaloids, saponins, phenols, tannins, and flavonoids which have antioxidant, anti-inflammatory, and antibacterial activities. The nanoemulgel preparation was chosen because it can penetrate well and quickly into the mucosa thereby increasing absorption. Physical stability tests need to be carried out to ensure the quality, safety and benefits of the gel meet the expected specifications and stable during storage. Objective: This study aims to determine which concentration has the most stable physical stability of pH and viscosity which were observed for 28 days. Materials and Methods: This was an experimental laboratory design, with 30 preparation divided into 3 groups, group of 30%, 40%, and 50% concentration preparation of nanoemulgel leaves of Phaleria macrocarpa. which were tested for pH tests and viscosity tests for 28 days which was observed every 7 days in climatic chamber. The pH and viscosity tests among groups were compared and analyzed by the Repeated Anova and Pos Hoc test. Results: Average pH test and viscosity test 30% concentration with the average baseline and h+28 pH values were 5,02 and 4,97 and the baseline and h+28 viscosity values were 1610 cPas and 1520 cPas. The results of the average concentration of 50% pH value at baseline = 4,65 and h+28 = 4,60. The mean baseline viscosity value=1290 cPas and h+28=1170 cPas. The results of the post-Wilcoxon test showed p>0.05 in the 30% concentration group for pH and viscosity tests showed that there was no significant difference in pH and viscosity values at a concentration of 30%, It means the pH value and viscosity of the 30% concentration preparation of nanoemulgel were relatively constant from baseline to h+28. Conclusion: It can be concluded that the pH and viscosity test of the preparation of nanoemulgel leaves of Phaleria macrocarpa at a concentration of 30% was the most stable pH and viscosity compared to concentrations of 40% and 50%.
Knowledge of Mothers' Behavioral Training About Oral Hygiene of Elementary School Children at RSGM Baiturrahmah
Authors: Sri Pandu Utami  , Atikah Putri Sakinah
Published: March 2023

Background Parents need to know, how to teach and train their children to take care of their teeth from early age because because early age child have reached motor maturity followed by intellectual development. Parents who have low knowledge children's care tend to ignore and not support their children's dental health. Parents and children must work together to maintain good oral hygiene.It can be seen that poor parental attitudes generally reflect poor oral health in children and vice versa. Objectives: to describe mothers’ knowledge about oral hygiene attitudes and practices out how the role of mothers in maintaining children's teeth and to determine the health of children's teeth. Methods: using questionnaires and descriptive analysis of probability sampling approach by combining aspects of stratification and cluster sampling in the IKGA (Ilmu Kedokteran Gigi Anak) lab room, Baiturrahmah University, around 30 respondents were sampled in each place and randomly selected. Results: from the results of the study, it was found that mothers who graduated from school were 34.72% and mothers who graduated from diploma/bachelor were 65.28% of the population, 10 (35%) have only attended elementary school and 20 (65%) mothers  who graduated. Conclusion: Mothers are less aware of dental disease prevention measures, the importance of brushing teeth, and visits to the dentist. Therefore, it is the responsibility of the government and health service providers to provide knowledge on oral health to mothers, because they are role models for their children.
PERLINDUNGAN HUKUM TERHADAP GURU DALAM PENYELENGGARAAN PENDIDIKAN DI KOTA KENDARI
Authors: Hasima Rahman
Published: March 2023

Tujuan penelitian ini adalah untuk mengetahui faktor-faktor penyebab lemahnya perlindungan hukum terhadap guru dalam penyelenggaraan pendidikan di Kota Kendari dan upaya pemerintah Kota Kendari dalam memberikan perlindungan hukum terhadap guru. Tipe penelitian yang digunakan adalah normatif empiris dengan menggunakan metode pengumpulan data melalui studi lapangan dan studi kepustakaan dan di analisis secara deskriptif kualitatif. Hasil penelitian menunjukan bahwa 1) Faktor-faktor lemahnya perlindungan hukum terhadap guru dalam penyelenggaraan pendidikan di Kota Kendari adalah a) Faktor budaya hukum masyarakat menjadi faktor utama lemahnya perlindungan hukum terhadap guru di Kota Kendari, faktor instrumen hukumnya, dan faktor aparat penegak hukumnya. 2) Upaya peningkatan perlindungan hukum terhadap guru dalam penyeleggaraan pendidikan di Kota Kendari adalah sebagai berikut: a) penegakan hukum perlindungan guru, b) sosialisasi atau penyuluhan mengenai perlindungan guru, c) pembentukan lembaga perlindungan guru, dan d) pembentukan peraturan daerah tentang perlindungan guru.
Distribution of Risk Factors and Mode of Delivery in Pregnant and Postpartum Women with Covid-19
Authors: Ayu Nanta Deo Apringga , Rahmadiany Puspita Deasy , Nupikso Wasis , Damanik Andoharman , Hasanah Fitria Nur
Published: March 2023

In the beginning of 2020, COVID-19 widely spread from Wuhan City of China causing a global pandemic. Pregnant women are a group that is prone to suffer from this disease due to their physiology and immune response changes. In the early stages of pregnancy, COVID-19 infection has the potential to affect organ growth and fetal development. Risk factors, such as late pregnancy, obesity, diabetes mellitus, and cardiovascular disease have been found to cause more severe manifestation and can increase the risk of premature birth to abortion.  There is also a risk for vertical transmission which further endanger the postnatal outcome. The purpose of this study is to figure out the depiction of distribution of risk factors and mode of delivery in pregnant and postpartum women to better understand the major health problem that commonly found and which mode physicians preferred for safe delivery. This study uses an analytical descriptive approach with cross-sectional design in a period of April 2020 to September 2021 in Regional General Hospital Sidoarjo.. 231 respondents were selected with total sampling of the population and are based on the positive result of antigen swab and/or RT-PCR COVID-19 test and risk factor categories which has been determined. The obtained data then statistically analyzed using The IBM SPSS Statistics and described in a table. The result of this study showed that the majority of respondents are not in the risk category yet certain conditions are commonly found and C-section is preferred for delivery.
Clinical Manifestation of Childhood Diphtheria
Authors: Zulfan Geune Putroe , Sihombing Jumaini Adriana , Amin Desrinawati Muhammad , Widiantari Aninda Dinar , Berti Monalisa Putri Eka , Murtiani Farida
Published: March 2023

Even though diphtheria vaccination has been routinely done all around the world, some of developing country still reported outbreak. Indonesia declared diphtheria outbreak in 2017. Diphtheria is characterized by sore throat, fever and the formation of pseudo-membrane located in the tonsils, pharynx or nasal cavity. Diphtheria is very common in children. This study was conducted to determine the clinical picture of diphtheria in children at Sulianto Saroso Infectious Disease Hospital January 2018 - December 2018. The study was descriptive cross – sectional using medical records of diphtheria patients for the period January 2018 – December 2018. The sample is 141 diphtheria patients with the total sampling method. Data analysis using univariate. In this study, out of 141 children with diptheria, the highest number of cases was recorded boy (58,2%), among 6-11 years old, and fully vaccinated (60.3%). Most patient complained about sore throat (95%), fever (93.6%), and bullneck (32.6%). Majority of diphtheria patients with bilateral tonsillar membranes were also found (71.6%), followed by the majority of negative culture results (66.7%), experienced no complications (78.7%), and discharge (99.3%). Clinical characteristic that commonly appeared were sore throat, fever, and bilateral tonsillar membrane. We found it is important to diagnose and treat early to prevent complication and mortality.
Date Palm (Phoenix dactylifera L.) Flour as an Alternative Culture Media for the Growth of Escherichia coli and Bacillus cereus
Authors: Rini Chylen Setiyo , Saidi Ida Agustini , Rohmah Jamilatur
Published: March 2023

The high cost of bacterial growth culture media can result in obstacles in the process of practicum or research in the field of microbiology. Date palm (Phoenix dactylifera L.) is the oldest fruit plant that grows in the Arabian Peninsula, North Africa and the Middle East. Dates are a source of high energy food with sugar content of 72% - 88%. This research was conducted to test the ability of date palm flour to grow Escherichia coli and Bacillus cereus bacteria as an alternative medium to replace NA media. In this study using total number of bacteria/ TPC (Total Plate Count) method to calculated the number of colonies of bacteria. The results of this study the number of colonies of Escherichia coli bacteria was more than the number of colonies of Bacillus cereus, that is 54 x 105CFU/g on concentration media 8 gr. When compared with NA media, date palm flour media can be used as an inexpensive alternative culture medium for bacteria.
Wide Margin Excision in Patients with Giant Condyloma Acuminata
Authors: Pratama Lucky , Setyowatie Lita , Retnani Diah Prabawati
Published: March 2023

Giant condyloma acuminata (GCA) is one of sexually transmitted infections caused by the Human Papilloma Virus (HPV) infection, specifically HPV types 6 and 11. Giant condyloma acuminata is a rare disease with an incidence of around 0.1%. The age distribution peaked in 25-29 years. The higher prevalence of infection is associated with number of sexual partners, history of chlamydia and gonorrhea infection, smoking and human immunodeficiency virus (HIV) infection. A 24 years old male presented with a cauliflower-like mass on the penis that has been growing slowly for 2 years. Physical examination of the penis revealed a pedunculated reddish verrucous mass, mobile, well-defined, 5x2x1.5 cm in size, and positive acetowhite test. The histopathological picture is in accordance with condyloma acuminata. Surgery with wide margin excision was performed to remove the lump. After 14 days post-surgery, the wound was healed completely without any sign of recurrence.
Prince A. G. Shcherbatov (1850-1915) – an outstanding Russian agrarian educator of the late XIX – early XX century. Part I
Authors: Kozlov Sergey Alekseevich
Published: March 2023

The paper examines the activities of the outstanding Russian landowner, innovator and educator, public figure of the turn of the XIX-XX centuries Prince Alexander Grigoryevich Shcherbatov (1850-1915). The aim of the study is to identify the features of development of A. G. Shcherbatov’s economic and educational work. The scientific novelty of the study lies in highlighting and characterising the main areas of A. G. Shcherbatov’s multifaceted activities. As a result of the study, it has been found that A. G. Shcherbatov attributed the successful conduct of economic and educational work to the support of the rural population, the agrarian innovator analysed the conditions for peasant farming development in Central Russia and proposed specific measures to improve economic work and culture promotion. As a full member and president of the Imperial Moscow Agricultural Society, A. G. Shcherbatov contributed to the elaboration of various scientific and practical issues in the field of agrarian science, as well as to the active introduction of advanced efficient methods into Russian agriculture, at the same time successfully promoting these methods among peasants and land-owning nobles. The research on this topic will be continued in the next publication.
ПРОБЛЕМИ АВТОРСТВА ТВОРІВ НАУКИ У ПЛОЩИНІ АКАДЕМІЧНОЇ ДОБРОЧЕСНОСТІ
Authors: Федоренко Яніна , Дмитренко Марія , Кришталь Аліна , Чубіна Тетяна
Published: March 2023

Among the problems of authorship in the plane of academic integrity, we include artificial academic promotion and increasing rating indicators; ‘honorary’ and ‘phantom’ authorship; improper financial benefits; hindering the professional development of res
Современные тенденции в химии стероидов
Authors: Соколов Михаил Николаевич , Рожков В. В. , Трухан В. М. , Шимановский Н. Л.
Published: March 2023

В обзоре проанализированы и обобщены литературные данные за последние 10 лет, посвященные поиску новых лекарственных препаратов на основе синтетических стероидов. Описаны современные способы улучшения эффективности стероидных соединений. Рассмотрены способы улучшения и модулирования их фармакологического профиля и биологической активности. Главное внимание уделено зависимости биологической активности от химической модификации стероидного скелета или его боковой цепи. Особо отмечена роль соединений, содержащих стероидный каркас, в терапии гормонозависимых опухолей.
Вопросы определения размеров частиц различных лекарственных средств при оценке их качества
Authors: Гунар Ольга В. , Доренская Анна В.
Published: March 2023

В представленной статье рассмотрены вопросы определения размеров частиц различных лекарственных средств (ЛС) и методы их анализа, а также установленные в нормативной документации (НД) требования к качеству ЛС по показателю «Размер частиц». Анализ НД показал, что общим при нормировании размера частиц для большинства лекарственных форм (ЛФ) является требование отсутствия частиц размером более 100 мкм. Представлены обнаруженные исключения от стандартного подхода к нормированию. Необходимо учитывать, что требования к качеству ЛС по показателю «Размер частиц» имеются в общей фармакопейной статье (ОФС) на каждую ЛФ. Основной применяемый метод оптической микроскопии описан в ОФС 1.2.1.0009.15 «Оптическая микроскопия» Государственной фармакопеи Российской Федерации (ГФ РФ) и ОФС 2.1.9.13 Фармакопеи Евразийского экономического союза (ЕАЭС). В рамках настоящей работы был выполнен ретроспективный анализ качества около 500 наименований различных ЛФ. Результаты выполненных испытаний демонстрируют, что за последние годы 78,2 % испытанных при прохождении фармацевтической экспертизы препаратов относились к ЛФ для местного и наружного применения, среди которых процент несоответствия требованиям составил 1,3.
Влияние новых производных 3-гидроксипиридина на NMDA-индуцированную дегенерацию сетчатки
Authors: Победа Анна Сергеевна , Соловьев Николай Вадимович , Покровский Михаил Владимирович , Скачилова София Яковлевна , Ефименко Светлана Владимировна , Симакина Екатерина Александровна , Башук Виктория Владимировна , Проскурина Оксана Владимировна , Должиков Александр Анатольевич , Нестерова Наталья Игоревна
Published: March 2023

Глутаматной эксайтотоксичности отводится ключевая роль в нейродегенерации сетчатки. Являясь основным возбуждающим нейромедиатором, глутамат в избыточном количестве провоцирует эксайтотоксичность, приводя к гибели ганглионарных клеток сетчатки. Нами была изучена фармакологическая активность новых соединений, производных 3-гидроксипиридина, под лабораторным шифром ЛХТ 1-21 и ЛХТ 6-20, на модели повреждений сетчатки, вызванных интравитреальным введением N-метил-D-аспартата (NMDA) крысам. Через 7 дней после введения NMDA было выявлено, что наибольшей активностью обладало соединение ЛХТ 6-20. ЛХТ 6-20 в дозе 25,5 мг/кг при внутримышечном введении в течение 7 дней приводит к увеличению уровня микроциркуляции в сетчатке на 48 %, по сравнению с этим показателем у животных, получавших NMDA (p < 0,05); а также увеличению амплитуды α-волны на 37,8 % (p < 0,05), β-волны на 53,7 % (p < 0,05) по сравнению с группой повреждений сетчатки; увеличению количества ядер в ганглионарном слое на 87,7 %, по сравнению с группой NMDA (p < 0,05). Высказано предположение о том, что соединение ЛХТ 6 – 20 оказывает ретинопротективное действие на модели NMDA-индуцированной эксайтотоксичности сетчатки.
Антиоксидантные и гепатопротекторные свойства комплексов моноаммонийной соли глицирризиновой кислоты c аминокислотами и фенольными соединениями
Authors: Махмудов Л. У. , Арипов Т. Ф. , Выпова Н. Л. , Нурбекова Н. Б. , Юлдашев Х. А. , Эсанов Р. С. , Гафуров М. Б. , Якубова Р. А. , Тагайалиева Нигора Абдунабиевна
Published: March 2023

Получен ряд супрамолекулярных комплексов моноаммонийной соли глицирризиновой кислоты (моноаммония глицирризинат, MG) с низкомолекулярными биологически активными соединениями: с аминокислотами — аргинин (Arg), метионин (Met), триптофан (Trp), цистеин (Cys), DL-карнитин·HCl (Car); с фенольными соединениями — кверцетин (Que), рутин (Rut), коричная (CinA), метоксикоричная (MethA) и феруловая (FA) кислоты. Проведено изучение антиоксидантной (AOA) in vitro и гепатопротекторной (ГПА) in vivo активности новых соединений в эксперименте. При исследовании AOA аминокислот и полифенолов показана наибольшая активность для Rut, Que и MethA. Комплексообразование изученных антиоксидантов приводит к увеличению AOA соединений в 1,5 – 6,5 раз (p < 0,05). Наиболее активными по AOA оказались комплексы MG с MethA, Car и Met. При внутрижелудочном ведении в дозе 5 мг/кг мышам с CCl4-индуцированным гепатитом высокую степень ГПА проявили комплексы MG/MethA, MG/Met и MG/Que, среднюю степень — MG/Rut, MG/Car и MG/FA. Введение комплексов MG/Car и MG/Cys приводит к снижению весовых коэффициентов печени в среднем на 35 и 30 % соответственно (p < 0,05 относительно контрольных значений). Наиболее активными по изученным параметрам оказались комплексы моноаммония глицирризината с MethA, Met, Que, Car и Cys, перспективные для дальнейшего исследования.
Mechanical Evaluation of Road Durability Test in Battery Electric Buses
Authors: SAVRAN Efe , YILDIRIM Burcu , ÇANDIR Umut , KARPAT Fatih
Published: March 2023

In addition to the significant contribution of electric vehicles to energy consumption and carbon emissions, the fact that they are quiet and highly sustainable in terms of use causes an increase in demand. Buses, which are a type of public transportation vehicle among vehicles, are of great importance for transportation, providing fuel savings for society in general and being a solution to the traffic problem. Gathering two separate phenomena such as electricity and a bus under one roof raises the impact values of the concepts to a higher level. In addition to having systemic differences, electric vehicles should be put into use in a way that is ready to provide long-term service in operating conditions, similar to conventional vehicles. To prove the readiness for use of the vehicles, they are subjected to multiple stages of testing simulating real operating conditions. At the end of the test process, if the vehicle meets the predetermined criteria, the test process is completed, and the vehicle is approved. In this study, two different battery electric bus models were subjected to road endurance tests and critical parts were determined and product reliability was ensured by making product development studies. The results of the study revealed the areas that should be considered in terms of periodic maintenance in electric vehicles.
Is an “Open Innovation” Policy Viable in Southeast Asia? - A Legal Perspective
Authors: Smith Robert , Perry Mark
Published: March 2023

In recent years, particularly in Europe, increasing attention is being paid to managing Intellectual Property (IP) competitive effects. Europe achieves greater innovation output with IP overall whilst also implementing the globally harmonised IP laws. The performance differences in innovation output are due to many variables. However, the EU has focussed on three policy goals: “open innovation”, “open science”, and “open to the world”, aiming to foster access to knowledge for advancement as well as overcoming innovation barriers while retaining alignment with harmonised international IP frameworks. Whilst it is still premature to draw conclusions about the effectiveness of the EU approach, it is possible to hypothesise whether such an approach is a viable option in Asia. In this case, the focus will be on the eleven countries of the Southeast Asia region with their various levels of development, from least developed (Cambodia, Laos, Myanmar and Timor-Leste) to highly developed (Singapore). The paper describes the concept of the EU “open innovation” policy, its drivers and its legal basis. From these examples, a framework will be developed against which to test its viability in Southeast Asia. Analysis shows that each of the ten ASEAN member states, including Singapore, is a net importer of patents rather than a developer. Nonetheless, it is considered that the IP ecosystems in Malaysia, Singapore, Thailand and Vietnam are sufficiently robust to at least consider a trial of the Open Innovation, Open Science and Open to the World concepts as being tested in the European Union. Keywords: “Open Innovation”; European Union; Association of Southeast Asian Nations; Intellectual Property legislation
Métodos e Indicadores para Avaliação de Resultados da Assistência Farmacêutica Hospitalar: uma revisão de escopo
Authors: LEITE Nayara S. , VIEIRA Fabiola S.
Published: March 2023

Objetivos: Identificar métodos e indicadores aplicados à avaliação dos resultados da assistência farmacêutica hospitalar (AFH). Métodos: Realizou-se uma revisão de escopo, considerando as recomendações PRISMA. A busca foi feita nas bases de dados EMBASE, MEDLINE e LILACS. A análise buscou explorar os métodos e indicadores empregados, e identificar as dimensões da qualidade investigadas. Resultados: De 418 artigos analisados, seis foram incluídos no estudo. Todos empregaram métodos quantitativos e os indicadores utilizados analisaram a efetividade, aceitabilidade, eficiência e otimização do cuidado farmacêutico. Conclusão: Conclui-se que os estudos de avaliação de resultados da AFH ainda são escassos e que há uma lacuna de conhecimento, especialmente quanto aos indicadores de eficácia, legitimidade e equidade do cuidado nessa área. Entretanto, foram identificados indicadores simples, de fácil aplicação e baixo custo, que podem ser utilizados na avaliação da AFH quanto à sua efetividade, aceitabilidade, eficiência e otimização.
Binormal and complex symmetric weighted composition operators on the Fock Space over $\mathbb{C}$
Authors: Santhoshkumar C.
Published: March 2023

In this paper, we give simple characterization of binormal weighted composition operators $C_{\psi, \phi}$ on the Fock space over $\mathbb{C}$ where weight function is of the form $\psi(\zeta) = e^{\langle \zeta, c \rangle}$ for some $c \in \mathbb{C}$. We derive conditions for $C_{\phi}$ to be binormal such that $C^*_{\phi}C_{\phi}$ and $C^*_{\phi} + C_{\phi}$ commute. Finally we give some simple characterization of binormal weighted composition operator to be complex symmetric.
La disfuncionalidad del federalismo argentino en el desarrollo económico-social de las provincias: el caso Corrientes. Perspectivas de las regiones como alternativa
Authors: Mariño Fages Jorge Raúl
Published: March 2023

La Argentina adoptó por la Constitución Nacional de 1853/60 la forma Federal de estado, por lo que se crearon dos órdenes jurisdiccionales: el nacional y el provincial, reconociendo incluso la preexistencia de las provincias a la Nación y en orden a ello se establecieron competencias reservadas de las provincias, competencias delegadas a la nación y competencia concurrentes entre ambas. Para que la autonomía de las provincias fuera efectiva tenían que contar con los recursos económicos y financieros suficientes para su subsistencia y desenvolvimiento. Por ello en la Carta Magna se reguló también el sistema rentístico, que con el tiempo fue perdiendo funcionalidad, por un proceso de concentración poblacional y de recursos económicos alrededor de la ciudad de Buenos Aires que se ha vuelto estructural, que compromete el desarrollo de las provincias. Ante esta realidad la reforma constitucional de 1994, contempla la posibilidad de que las provincias se reúnan en regiones. En ese sentido la Provincia de Corrientes se ha integrado a la región del Norte Grande.
Fractalkine levels in patients with type 2 diabetes mellitus with various body weight
Authors: Kobrynska O. Y.
Published: March 2023

The obesity and diabetes mellitus (DM) are considered as concomitant pathologies in the most cases. The risk of developing cardiovascular and overall mortality increases even when the upper limit of normal body weight is reached. The chemokine family is important in the pathogenesis of cardiovascular diseases, as it activates leukocytes and provokes their adhesion to the vascular wall, i.e., increases inflammation in the endothelium, and plays an important role at all stages of cardiovascular diseases (CVD).
Objective — to investigate the fractalkine level in patients with type 2 diabetes mellitus with various body weights and to establish correlations between fractalkine and cardiovascular risk factors, cytokine levels, and morpho functional parameters of the heart.
Materials and methods. Examinations involved 100 patients with type 2 DM with normal, overweight, and obesity of varying degrees; the control group consisted of 10 practically healthy subjects. The mean age of patients was 47.9±3.4 years. Patients didn’t have history of CVD or CVD signs during examinations, part from arterial hypertension. Echocardiography and assessment of fractalkine levels were performed to all patients.
Results. A significantly higher fractalkine level was found in all patients with type 2 DM compared to the control group. There was a significant increase in the levels of this indicator depending on body mass index. It was found that there was a direct correlation between average strength with body mass index (r=0.45; p=0.0001), thickness of the left ventricular posterior wall (r=0.53; p=0.0005), left ventricular myocardial mass index (r=0.589; p=0.0005), and left atrium (r=0.49; p=0.0005); a strong correlation with waist circumference (r=0.72; p<0.0001), a moderate correlation with total cholesterol (r=0.46; p=0.0005), a significant correlation (r=0.62; p<0.00001) with glycated hemoglobin. There was also a significant relationship between fractalkine level and interleukin‑6 (0.69; p=0.0005) and C‑reactive protein (0.63; p<0.00001), a significant relationship (r=0.63 p<0.00001) between fractalkine and leptin levels.
Conclusions. The study results demonstrated that in patients with type 2 DM, and an increase in body mass index, the level of blood fractalkine significantly increases, which closely correlates with waist circumference, indicators of carbohydrate and lipid metabolism, and pro‑inflammatory cytokines. A significant relationship was found between fractalkine levels and left ventricular posterior wall thickness, left ventricular, and left atrial myocardial mass index.
Thyroid follicular carcinomas: current state of the problem and long-term results of treatment
Authors: Bolgov M. Y. , Zelinska H. V. , Tarashchenko Y. M. , Melnik M. D.
Published: March 2023

Thyroid follicular tumors remain a difficult category for both cytological and histological diagnosis, due to the lack of reliable cellular signs of malignancy. An important innovation of the 2022 classification is the appearance of a whole group of low‑risk thyroid neoplasms, which took an intermediate place between the groups of benign and malignant neoplasms. Despite the success of cytological diagnosis of thyroid neoplasms, there are unresolved issues related to the diagnosis of follicular neoplasias, which are considered a «gray zone» of cytological diagnosis.
Objective — to perform a retrospective analysis of the long‑term results of diagnosis and surgical treatment of patients with thyroid follicular carcinoma.
Materials and methods. The research material was the results of treatment of 113 patients who were operated on in the surgical clinic of the V.Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Sciences of Ukraine due to the thyroid follicular carcinoma. All patients had a pre‑operative cytological conclusion from the Institute's laboratory and were observed by specialists for at least five years (maximal term 35 years).
Results. Bethesda group IV («follicular neoplasia») was established in 24.8% of cases. A cytological conclusion about a malignant process (Bethesda VI) or a suspicion of it (Bethesda V) was established in 27.4% (15% and 12.4%, respectively). In 41.6% of cases, the Bethesda II group («benign process») was determined, i.e., there were no doubts about the benign nature of the formation at all. According to the final pathological diagnosis, 8 cases were classified as widely invasive follicular carcinoma, 15 were classified as angioinvasive, and 90 were minimally invasive. The combination of signs of thyroid carcinoma with papillary carcinoma was indicated in 5 cases, 4 of them were present in the presence of minimally invasive carcinoma, in one case — widely invasive. In general, the obtained data indicated a favorable prognosis of minimally invasive follicular carcinomas and allowed to confirm the opinion that in general they do not require radioiodine therapy. The performance of definitive thyroidectomy concluded to be debatable.
Conclusions. The obtained results have shown that thyroid cancer remains difficult to diagnose and predict, but in the most cases, it is effectively cured. In the past decades, the attitude towards all follicular carcinomas was more «aggressive», which needs to be revised in view of new data and corresponds to modern world trends.