bluuebunny/crossref_metadata_2025 huggingface dataset:
Lithium intercalation mechanisms and critical role of multi-doping in LiFexMn2-x-yTiyO4 as high-capacity cathode material for Lithium-ion batteries
Authors: Callegari Daniele , Fracchia Martina , Coduri Mauro , Ghigna Paolo , Braglia Luca , Anselmi Tamburini Umberto , quartarone eliana
Published: February 2022

The ever-growing demand for Li-ion batteries requires high-capacity electrode materials that should also be environmentally benign, Co-free, secure and durable, to achieve an optimal compromise between sustainability and functional performances. Spinel LiMn2O4 (LMO) is a state-of-the-art material, which, in principle, could satisfy such requirements. However, an undesired cubic-tetragonal phase transition favors Jahn-Teller (J-T) spinel distortion, leading to severe capacity reduction upon cycling below 3 V. Here, we propose a dual-doping strategy for LMO, based on the partial substitution of Mn(III) with Fe(III) and Ti(IV) to design new active materials for high-capacity cathodes, namely LiFexMn2-x-yTiyO4 (LFMT), with Li/Mn ratio ranging between 1 and 1.7. The substitution of Mn with Fe and Ti suppresses the J-T distortion, which is often still evident in the case of Ti-doped LMO. This allows cycling in a wider voltage range (4.8-1.5 V), thus resulting in higher capacity and significantly improved stability. The lithiation mechanisms were investigated by combining ex-situ X-ray diffraction (XRD) and X-ray absorption spectroscopy (XAS analyses). It demonstrated that the only redox-active metal is Mn, while Fe and Ti are electrochemically inactive. The extensive electrochemical lithiation/delithiation of the LFMT compositions brought to unprecedented results, which give evidence of stabilizing cation disorder through the formation of Mn-rich and Mn-poor domains, which leades to two spinel phases with different Mn:Ti ratios. These insights into the lithiation mechanism pave the way for a better understanding of the doping chemistry and electrochemistry of Mn-based spinels as cathode materials for Li-ion batteries.
Evaluating the use of absolute binding free energy in the fragment optimization process.
Authors: Alibay Irfan , Magarkar Aniket , Seeliger Daniel , Biggin Philip
Published: February 2022

Key to the fragment optimization process is the need to accurately capture the changes in affinity that are associated with a given set of chemical modifications. Due to the weakly binding nature of fragments, this has proven to be a challenging task, despite recent advancements in leveraging experimental and computational methods. In this work, we evaluate the use of Absolute Binding Free Energy (ABFE) calculations in guiding fragment optimization decisions, retrospectively calculating binding free energies for 59 ligands across 4 fragment elaboration campaigns. We first demonstrate that ABFEs can be used to accurately rank fragment-sized binders with an overall Spearman’s r of 0.89 and a Kendall τ of 0.67, although often deviating from experiment in absolute free energy values with an RMSE of 2.75 kcal/mol. We then also show that in several cases, retrospective fragment optimization decisions can be supported by the ABFE calculations. Cases that were not supported were often limited by large uncertainties in the free energy estimates. Comparing against cheaper endpoint methods, namely Nwat-MM/GBSA, we find that ABFEs offer better ranking power and correlation metrics. Our results indicate that ABFE calculations can usefully guide fragment elaborations to maximize affinity.
Nutrient recovery from wastewater in India: A perspective from mass and energy balance for a sustainable circular economy
Authors: Gowd Sarath C. , Rajendran Karthik
Published: February 2022

Limited global phosphorus availability and increased eutrophication due to discharge of nitrogen pushed everyone to rethink the way, on how to recover nutrients. Wastewater is a potential source to recover N and P, while in India, it is scarcely explored. Understanding nutrient recovery systems involve exploring individual unit operations, sizing, and their energy consumption. Most studies on nutrient recovery from wastewater have focussed on retrieving, while least studies focused on mass and energy balance, which holds the key for its application potential. In this work, four different nutrient recovery system was compared, when added to an STP plant for a mid-size city in India. The results indicate that fuel cells consume the lowest energy at 216.2 kWh/1000m3, while microalgae used the highest energy at 943.3 kWh/1000m3. However, from a cost point of view except microalgae (78.6$/1000 m3) other nutrient systems did not yield any savings.
Atomic force microscopy characterization of polyethylene terephthalate grafting with poly(styrene sulfonate)
Authors: Nguyen Tuan , Humblot Vincent , Migonney Veronique , Levy Raphael
Published: February 2022

Polyethylene terephthalate (PET) is widely used to elaborate biomaterials and medical devices in particular for long-term implant applications but tuning their surface properties remains challenging. We investigate surface functionalization by grafting poly(sodium 4-styrene sulfonate, PNaSS) with the aim of enhancing protein adhesion and cellular activity. Elucidating the topography and molecular level organization of the modified surfaces is important for understanding and predicting biological activity. In this work, we explore several grafting methods including thermal grafting, thermal grafting in the presence of Mohr's salt, and UV activation. We characterize the different surfaces obtained using atomic force microscopy (AFM), contact angle (CA), and X-ray photoelectron spectroscopy (XPS). We observe an increase in the percentage of sulfur atoms (XPS) that correlates with changes in (CA), and we identify by AFM characteristic features, which we interpret as patches of polymers on the PET surfaces. This work demonstrates tuning of biomaterials surface by functionalization and illustrates the capability of atomic force microscopy to provide insights into the spatial organization of the grafted polymer.
A Comparative Evaluation of Indirect Sequence-Specific Magnetoextraction-aided Fluorescence and Electrochemical LAMP with SARS-CoV-2 Nucleic Acid as the Analyte
Authors: Tripathy Sayantan , Agarkar Tanvi , Talukdar Arunansu , Sengupta Mrittika , Kumar Ashvani , Ghosh Souradyuti
Published: February 2022

Since the beginning of the SARS-CoV-2 pandemic, nucleic acid amplification test (NAAT) such as quantitative real-time reverse transcriptase PCR (qRT-PCR) has remained the primary intervention for diagnostics and containment of SARS-CoV-2. Despite its remarkable clinical as well as analytical specificity and sensitivity, qRT-PCR necessitates pure nucleic acid free of any polymerase inhibitors (from complex biological matrices) as its substrate. Similarly, isothermal NAATs (iNAATs), despite their advantage over qRT-PCR in terms of thermal cycler independence, still require pure nucleic acid as a template. The requirement of pure nucleic acid in turn warrants the use of spin-column mediated extraction with centralized high-speed centrifuges. Additionally, utilization of centralized real-time fluorescence readout and use of sequence-specific molecular probes like TaqMan further prevent their deployment in decentralized locations. To circumvent these disadvantages, we have envisioned a sample-to-answer workflow comprising of indirect sequence-specific magneto-extraction (also referred to as magnetocapture, magneto-preconcentration, or magneto-enrichment in this manuscript) followed by in situ fluorescence or electrochemical LAMP. This study, using SARS-CoV-2 nucleic acid as the analyte, compared the analytical effectiveness of indirect and direct sequence-specific magneto-extraction followed by LAMP. Since contamination carryover may affect the efficacy of sequence-specific indirect magnetocapture, its performance in presence of excess host nucleic acid or serum was probed. Through these experiments, we have established a comprehensive limited resource-adoptable and highly specific nucleic acid detection method with the limit of detection of 2.5 copies/L. Its advantage lies in the flexibility of using either centralized real-time SYBR-based fluorescence LAMP or portable electrochemical LAMP as the readout. Simultaneously, the performance with magneto-capture aided fluorescence and electrochemical LAMP readouts were weighed against each other in terms of analytical sensitivity, specificity, and turnaround time. Additionally, the analytical efficacy of the magnetocapture-LAMP workflow was also checked against that of LAMP using pure nucleic acid as a template. Besides being the first report utilizing electrochemical LAMP to detect SARS-CoV-2 nucleic acid, this would probably be the first study to make the analytical comparative assessment of magnetic preconcentration combined with in situ fluorescence and electrochemical LAMP. It is probably also the first study (to the best of our knowledge) to compare the analytical efficacy of a sequence-specific magnetic target enrichment-LAMP (fluorescence and electrochemical) to that of a LAMP assay using pure nucleic acid as a template.
History of the discovery and study of tick-borne encephalitis in Russia: three Far Eastern expeditions (1937–1939)
Authors: Kolyasnikova Nadezhda M. , Zlobin Vladimir I. , Ishmukhametov Aidar A. , Maleev Viktor V.
Published: February 2022

The review provides a brief historical outline of the discovery and study of tick-borne encephalitis (TBE) during three expeditions to the Far East (19371939). As a result of the Far Eastern expeditions, the TBE virus was discovered, numerous strains were isolated, a vector-borne transmission pathway was established, the main features of epidemiology, clinic and pathomorphology of the disease were described, serotherapy was tested, first inactivated "brain" vaccine against TBE was developed and its effectiveness was proved. The history of the discovery and study of TBE is marked by the heroism of researchers and tragic events illness of some participants, death during the development of the first vaccine, arrest of L.A. Zilber and two performers.
Varicella-pox virus infection: features of the course, clinical manifestations, complications, and possibilities for prevention
Authors: Prikhodchenko Nelli G.
Published: February 2022

Varicella zoster virus (VZV) is a pathogenic human herpes virus that causes chickenpox as a primary infection, after which it persists for a long time and latently in the peripheral ganglia. Decades later, the virus can reactivate spontaneously, or after exposure to a number of triggering factors, causing herpes zoster (shingles). The reasons for the long-term persistence of VZV are gradually being revealed, but some issues remain unknown at the moment. Chickenpox and its complications are especially difficult in immunocompromised patients, but they are often found in people without risk factors. The most frequent and important complication of VZV reactivation is postherpetic neuralgia; encephalitis, segmental motor weakness and myelopathy, cranial neuropathies, and gastrointestinal complications often develop. The only scientifically proven effective and affordable way of mass prevention at the moment is vaccination. Chickenpox vaccines are safe and effective in preventing morbidity and mortality associated with the disease.
The problem of diagnosis and differential diagnosis of botulism in pregnant women. Case report
Authors: Malov Valerii A. , Tsvetkova Natalia A. , Baka Kirill N. , Volchkova Elena V. , Konnova Yulia A. , Maleyev Viktor V. , Gruzdeva Olga Yu. , Archngelskaya Irina V. , Maloletneva Natalya V. , Dmitrieva Lyudmila N.
Published: February 2022

The article describes a clinical observation of a severe course of a sporadic case of foodborne botulism in a woman at 32 weeks gestation with a successful resolution of pregnancy by independent childbirth. No adverse effects of botulism on pregnancy, delivery, and fetal development were noted. Anti-botulinum serum was administered to the patient no earlier than 96 hours from the onset of the disease. The paper analyzes the clinical picture of botulism, on the basis of which it is necessary to carry out a differential diagnosis.
COVID-19 in haemodialysis patients: result analysis of the first year of the pandemic
Authors: Zubkin Mikhail L. , Frolova Nadiya F. , Kim Irina G. , Ushakova Anzhela I. , Usatiuk Sergei S. , Iskhakov Rustam T. , Diakova Ekaterina N. , Chervinko Valeriy I. , Volodina Elizaveta V. , Tomilina Natalia A. , Kryukov Evgeniy V.
Published: February 2022

Background. Present concepts of the novel coronavirus infection prognosis in haemodialysis (HD) patients are rather controversial. There is little information on therapy efficiency and safety in such patients. We studied COVID-19 course specifics, prognostic factors associated with fatal outcomes, therapy efficiency and its transformation at different stages of the pandemic first year.
Materials and methods. Single-centre retrospective uncontrolled study included 653 COVID-19 HD-patients treated at Moscow City Nephrology Centre from April 1 to December 31, 2020.
Results. This period mortality rate was 21.0%. Independent predictors of COVID-19 unfavourable outcome in HD patients were pulmonary lesion extension (CT grades 34), high comorbidity index, and mechanical ventilation. Approaches to COVID-19 treatment modified significantly at different periods. Immunomodulatory drugs (monoclonal antibodies to IL-6, corticosteroids) were used largely at later stages. With tocilizumab administration, mortality was 15.1%, tocilizumab together with dexamethasone 13.3%; without them 37.8% (р0,001). Tocilizumab administration in the first 3 days after hospitalization of patients with CT grades 12 was associated with more favourable outcomes: 1 out of 29 died vs 6 out of 20 (tocilizumab administered at later periods); p0.04. There was no significant difference in death frequency in patients with CT grades 34 depending on tocilizumab administration time.
Conclusion. COVID-19 in HD patients can manifest in a severe course with unfavourable outcome. It is urgent to identify reliable disease outcome predictors and develop efficient treatment in this population.
CYP2C8, PTGS-1, 2 gene polymorphisms prevalence associated with sensitivity to non-steroidal anti-inflammatory drugs among North Caucasus ethnic groups
Authors: Abdullaev Sherzod P. , Denisenko Natalia P. , Mirzaev Karin B. , Shuev Gregorii N. , Sozaeva Zhannet A. , Kachanova Anastasia A. , Mammaev Suleiman N. , Kasaeva Elvira A. , Gafurov Danial M. , Grishina Elena A. , Sychev Dmitry A.
Published: February 2022

Aim. Find the prevalence of CYP2C8*3 (rs10509681; rs11572080), PTGS-1 (rs10306135; rs12353214) and PTGS-2 (rs20417) alleles and genotypes in four ethnic groups among Laks, Avars, Dargins and Kumyks.
Materials and methods. The study involved 400 volunteers from four ethnic groups living in Republic of Dagestan: 100 participants from each group. Carriage of polymorphic markers was determined by reverse transcription polymerase chain reaction.
Results. Minor allele frequency of the CYP2C8 (rs10509681) was 5.5% in Avars, 10% in Dargins, Laks and Kumyks 6.5% both; CYP2C8 (rs11572080) was 5.5% in Avars, 9.5% in Dargins, 6.5% in Laks, 8.5% in Kumyks; PTGS-1 (rs10306135) in Avars 10.5%, in Dargins 13.0%, in Laks 9.5% and Kumyks 7.5%; PTGS-1 (rs12353214) in Avars 9.0%, in Dargins 4.5%, in Laks 7.5%, in Kumyks 8.0%; PTGS-2 (rs20417) in Avars 1.0%, in Dargins 2.5%, in Laks 3.5%, in Kumyks 5.0%. There were no significant differences between groups.
Conclusion. The study of CYP2C8 and PTGS-1 and 2 gene polymorphisms is promising for predicting the effectiveness and safety of non-steroidal anti-inflammatory drug therapy, due to the high prevalence of these polymorphisms in ethnic groups in the North Caucasus.
Criteria for the optimal use of interleukin-6 receptor blockers in patients with COVID-19
Authors: Kruglova Tatyana S. , Fomina Darya S. , Poteshkina Nataliуa G. , Frolova Nadija F. , Beloglazova Irina P. , Mutovina Zinaida Yu. , Samsonova Inna V. , Kovalevskaja Elena A. , Zagrebneva Alena I. , Serdotetckova Sofya A. , Chernov Anton A. , Lysenko Maryana A.
Published: February 2022

Aim. To determine the criteria for the optimal use of IL-6 receptor blockers in patients with COVID-19 community-acquired pneumonia based on predictors of adverse outcomes.
Materials and methods. The single-center, non-randomized prospective study included 190 patients with community-acquired pneumonia caused by coronavirus 2 between the beginning of March and the end of May 2020. Of these, 89 patients received tocilizumab and 101 patients received sarilumab. The study inclusion criterion for the patient was indications for initiating therapy with one of the inhibitors of IL-6 receptors (anti-IL-6R) according to the Interim guidelines (versions 4 and 5). The exclusion criterion was the need to re-prescribe genetically engineered biological therapy (GEBT). The severity of the patient's condition was assessed according to the early warning score (NEWS2), the volume of lung tissue lesions was assessed according to computed tomography (CT). Laboratory monitoring included counting the absolute (abs) number of lymphocytes, serum levels of C-reactive protein (CRP), interleukin 6 (IL-6), D-dimer, lactate dehydrogenase, fibrinogen. Statistical data processing was conducted by nonparametric methods using the IBM SPSS Statistics V-22 software.
Results. The phenotype of a patient with a negative outcome prognosis was described: a male patient over 50 years of age with aggravated premorbid background (with cardiovascular diseases, obesity and/or chronic renal disease), lung lesion CT 34, saturation less than 93% upon inhalation of atmospheric air, persisting for 2448 hours after GEBT. According to the blood test, lymphopenia was below 1000 U/L and CRP levels were above 50 mg/L. The laboratory parameters and clinical picture of the patient progressively worsened after 911 days of illness, regardless of the use of Anti-IL-6R. The features of patients monitoring when administering IL-6 receptor blockers have been determined.
Conclusion. IL-6 receptor blockers should be administered to patients hospitalized with severe COVID-19 before the development of hyperinflammatory reactions. The optimal "therapeutic window" is 78 days of illness.
Shining Light On The Laying Hen Brain: The Effect Of Light During Incubation Depends On Cognitive Task And Hybrid
Authors: Manet Maëva , Kliphuis Saskia , Rodenburg T. Bas , Goerlich Vivian , Tuyttens Frank , Nordquist Rebecca
Published: February 2022

The influence of early life on animal welfare later in life is increasingly recognized as important. In chickens, a promising early-life intervention is the exposure to light during incubation. Due to the position of the embryo in the egg, the two brain hemispheres receive different amounts of light stimulation via the eyes. This unequal stimulation results in increased lateralization of the brain, which is the specialization of brain hemispheres on certain functions. In current commercial practice, chickens are incubated in complete darkness. Information about the effect of light during incubation on laying hen cognition is scarce, although stronger effects are expected in hybrids coming from white eggs than brown eggs. In this experiment, we therefore incubated eggs of ISA Brown (ISAb) and Dekalb White (DW) layer hybrids (N = 1200) either in a green light-dark cycle (light), or in complete darkness (dark). At hatching, brains were collected from 80 individuals. Tyrosine hydroxylase and DoubleCortin levels were investigated, but no significant differences were found between incubation treatments or hybrids. Then, cognition tests were performed on the surviving females. In a detour test (N = 198), light-exposed chicks showed 24% more lateralized behavior (i.e., turned left from the obstacle) than chicks incubated in the dark, regardless of the hybrid. In a 5-day holeboard test (N = 78), adult hen performance results were inconsistent. Finally, during a social recognition test (N = 76), ISAb-dark showed significantly greater interest for the familiar hen, whereas DW-light showed greater interest for the unfamiliar hen. To conclude, light during incubation affected the brains and cognition of laying hens at different life stages post-hatching, although the effects were not consistent across tests or hybrids.
Do bats use scent cues from guano and urine to find roosts?
Authors: Brown Bridget , Carter Gerald
Published: February 2022

Selection of habitat is a key determinant of reproductive success, and the process of finding and choosing these sites is often influenced by the presence of conspecifics. Many bats frequently switch roosts, and some bats repeatedly find new roosts. To find roosts with conspecifics or group members, bats can use social cues. However, most research on how bats use social cues for roost-finding has focused on acoustic cues. Here, we review and discuss the evidence for bat roost selection using scent cues from guano and urine stains, which are present at most bat roosts. We outline reasons why bats might, or might not, use scent in roost detection and selection, and we review evidence on the possible use of guano and urine in roost-finding from eight studies with 12 bat species (across four families). Overall, the sparse evidence that exists indicates that scent cues from guano and urine are not a strong and consistent lure in the species and situations that were tested. Most studies had unclear results or found no effect. Two of the eight studies found weak experimental evidence for bats using guano or urine to select a roosting site. Even if guano and urine can indicate the presence of bats at a roost, it is possible that the resulting olfactory cues do not contain sufficient social information to be used in roost selection, in contrast to olfactory cues from scent marking. Studies of how bats use sensory cues beyond sound could contribute to a better understanding of bat social behavior and roosting ecology.
Proteomic landscape of SARS-CoV-2– and MERS-CoV–infected primary human renal epithelial cells
Authors: Kohli Aneesha , Sauerhering Lucie , Fehling Sarah K , Klann Kevin , Geiger Helmut , Becker Stephan , Koch Benjamin , Baer Patrick C , Strecker Thomas , Münch Christian
Published: February 2022

Acute kidney injury is associated with mortality in COVID-19 patients. However, host cell changes underlying infection of renal cells with SARS-CoV-2 remain unknown and prevent understanding of the molecular mechanisms that may contribute to renal pathology. Here, we carried out quantitative translatome and whole-cell proteomics analyses of primary renal proximal and distal tubular epithelial cells derived from human donors infected with SARS-CoV-2 or MERS-CoV to disseminate virus and cell type–specific changes over time. Our findings revealed shared pathways modified upon infection with both viruses, as well as SARS-CoV-2-specific host cell modulation driving key changes in innate immune activation and cellular protein quality control. Notably, MERS-CoV infection–induced specific changes in mitochondrial biology that were not observed in response to SARS-CoV-2 infection. Furthermore, we identified extensive modulation in pathways associated with kidney failure that changed in a virus- and cell type–specific manner. In summary, we provide an overview of the effects of SARS-CoV-2 or MERS-CoV infection on primary renal epithelial cells revealing key pathways that may be essential for viral replication.
Isolasi Enzim Bromelin dari Buah Nanas dan Aplikasinya pada Pembuatan Kecap Berbahan Baku Keong Mas
Authors: Febrianto Adi Nugroho
Published: February 2022

Bromelin merupakan enzim proteolitik yang berasal dari buah nanas (Ananas comosus dan Ananas bracteatus). Sebagai enzim proteolitik, bromelin mampu memecah molekul-molekul protein menjadi bentuk asam amino. Pada penelitian ini enzim bromelin digunakan dalam pembuatan kecap dari keong mas sebagai katalis. Pembuatan kecap dari keong mas tersebut bertujuan untuk memanfaatkan kandungan protein yang terdapat pada keong mas. Diharapkan masyarakat khususnya petani akan mendapatkan manfaat dan nilai tambah dari pengolahan tersebut dengan mengusahakan

kecap keong mas sebagai penghasilan sampingan. Variabel yang dipelajari pada penelitian ini adalah perbandingan penggunaan komposisi antara bonggol nanas dengan keong mas pada perbandingan 1: 1 (A), 1: 2 (B), dan 1 : 3 (C) serta waktu proses hidrolisa enzimatis terhadap keong mas. Berdasarkan penelitian yang dilakukan, diperoleh hasil bahwa kecap yang paling disukai adalah kecap yang dibuat dengan perbandingan 1 : 2 dengan lama proses pembuatan 3 hari.
Karateristik Proses Pelapisan Emas pada Plastik Resin ABS
Authors: Abrianto Akuan
Published: February 2022

Penelitian ini bertujuan untuk membuat lapisan logam pada material dasar plastik yang bersifat non konduktor dengan menggunakan metode lapis listrik (electroplating). Dengan proses pelapisan ini diharapkan akan meningkatkan sifat fisik dan bertambah nilai estetika dari material plastik.

Lapis listrik adalah suatu proses pengendapan logam (misalnya: Ni, Cu, Zn, Au, dan sebagainya) pada permukaan material lain yang akan dilindungi dengan menggunakan proses elektrolisa. Kesulitan yang terjadi pada pelapisan ini adalah karena plastik bersifat non konduktor sehingga tidak dapat menghantarkan arus listrik. Supaya permukaan plastik dapat mengendapkan logam yang akan dilapiskan, maka harus diupayakan supaya permukaan plastik dapat menghantarkan arus listrik.

Pengendapan lapisan emas secara elektroplating tergantung pada larutan, rapat arus, dan tempertur yang digunakan. Penelitian ini menggunakan larutan tetap dengan memyvariasikan rapat arus, temperatur dan waktu pelapisan. Hasil pelapisan yang baik 2 A/dm2 denga
Henry's Constants Prediction Study of VOC in Several Types Solvents by UNIFAC-FV
Authors: Hendriyana
Published: February 2022

Absorption of hydrophobic volatile organic compounds (VOC) such as toluene, was studied. In order to characterise the absorption capacity of toluene/oil solvent systems, the Henry's constant (H) was determined. Prediction of Henry's constants are also carried out using UNIFAC-FV model which is known to be suitable for hydrocarbon gases and high-boiling point hydrocarbon solvent.kg/cm2, 220 kg/cm2 dan 260 kg/cm2.
Penjadwalan Batch pada Dua Mesin Homogen untuk Meminimasi Makespan
Authors: Rinto Yuriski
Published: February 2022

Prosedur batching atau teknik penjadwalan batch merupakan salah satu metoda yang banyak diterapkan dalam memecahkan masalah penjadwalan Penelitian ini akan membahas pemecahan masalah penjadwalan batch pada dua mesin homogen dengan tujuan untuk meminimasi Makespan. Motivasi pemecahan masalah diangkat dari permasalahan yang terjadi pada perusahaaan â€œMRâ€ yang bergerak dalam produksi pakaian jadi. Fokus pembahasan masalah terdapat pada pesanan baju ekslusive yang merupakan pesanan baju dengan jumlah tertentu dan dalam pengerjaanya hanya bisa dikerjakan oleh dua orang tenaga kerja ahli. Masalah yang timbul dari penerapan metoda penjadwalan perusahaan adalah sering ditemukan pembebanan yang kurang seimbang antar operator dan berdampak pada panjangnya lead time manufacturing (Makespan) suatu order. Solusi penjadwalan batch pada masalah ini terletak pada menentukan jenis pekerjaan yang harus dipotong, ukuran pemotongan (ukuran batch) dan urutan penjadwalan pekerjaan pada setiap mesin. Hasil pengujian analitik menunjukkan bahwa algoritma penjadwalan usulan dapat mereduksi Makespan hingga 2046 bila dibandingkan penjadwalan eksisting
Pemurnian Isopropanol Menggunakan Membran Alginat
Authors: Febrianto Adi Nugroho
Published: February 2022

Pemurnian Isopropanol agar mencapai kadar lebih dari 85% umumnya dilakukan dengan distilasi bertingkat yang membutuhkan banyak energi dan biaya. Untuk menghemat biaya, pemurnian Isopropanol dapat dilakukan dengan teknik pervaporasi menggunakan membran. Pada penelitian ini dilakukan teknik pervaporasi menggunakan bahan-bahan utama yaitu : Na-Alginat dengan variasi konsentrasi 4% dan 7%.; larutan CuSO4, dan CaCI2, (0.1 M, 0.5 M, IM) sebagai crosslinker. Hasil penelitian menunjukkan konsentrasi alginat paling optimum untuk pemisahan membran adalah Na-alginat 7%, sedangkan konsentrasi crosslinker optimum adalah 1M CuSO4 (É‘= 147 dan DOS= 4,72) bagi Na-alginat 7% dan 0.5M CaCl2 (É‘= 97 dan DOS= 36,90) bagi konsentrasi alginat 4%. Kondisi operasi dehidrasi isopropanol optimum dicapai pada suhu 50oC dengan konsentrasi umpan 75%.
The Figurative Language Used In Ayu Meutia's Poetry Tigress Based On Gibbs & Colston's Theory
Authors: Rejeki Christina Sri , Yulianti Fitri , Kustantinah Indri
Published: February 2022

The purpose of this article is to find the truth of Gibbs & Colston theory in Meutia’s poetry and to find out the types of figurative language and the most dominant kind of figurative language in Meutia’s poetry. The study focused figurative language in Meutia’s poetry Tigress. The study used descriptive qualitative method and Gibbs & Colston’s theory (2012) is used for identifying the figurative language. The writer chooses six poetries randomly. There are Moonset, Migration, Materialism, Your City, What Your Heart is Not, and Awkward Silence. Gibbs & Colston theory (2012) conducted about evaluating the use of metaphors, metonymy, irony, idioms, and proverbs. Gibbs & Colston (2012 : 19) state that special feature of figurative language may have much to do with their meaning products as with the cognitive processes used to create those meaning. The result of the study is idiom 1 data, irony 5 data, metaphor 133 data, and metonymy 2 data. Proverbs are not found in this study. Figurative language is found metaphor, metonymy, idiom, and irony.  The most dominant figurative language in Poetry Tigress is metaphor. Figurative language in poetry gives sense and beauty to the poem. It helps people to expression, description of something, to make easy people to reference of something, to give inspiration and motivation.  Keywords: Figurative Language, Poetry, Poetry Tigress
OPTIMIZATION OF ELEMENTS OF WINTER WHEAT CULTIVATION TECHNOLOGY USING NO-TILL TECHNOLOGY
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, DREPA E.B. , GOLOSNAYA E.L. , GOLUB A.S. , PSHENICHNIY R.N. , KALMYKOVA D.O.
Published: February 2022

The study aims to improve winter wheat cultivation technology in the arid zone of the Stavropol Krai based on the optimization and renewal of the variety base of winter wheat grown by No-Till technology. The authors carried out the work in 2019–2020 in the arid zone of the Stavropol Krai. In the experiment to evaluate winter wheat varieties grown on pea and sunflower forerunners, there were 15 varieties of different breeding. The variety Yuka was used as a control. The total size of the experimental plot – 1.9 ha. Pea forerunner yield was 23.92–39.44 c/ha, depending on the variety. The highest yielding variety was Tanya (39.44 c/ha), 12.6% higher than the farm variant Yuka (35.04 c/ha). The varieties Aksinya and Volny Don increased 4.8–7.1% compared to the Yuka variety. All studied varieties showed a relatively high degree of resistance to the development of pathogens. The highest coefficient of prevalence and intensity of pyrenophorosis in winter wheat plants sown after peas were observed in the variety Alekseich with 67% prevalence and 0.63% intensity, and the lowest in the variety Aist with 22% and 0.33%, respectively. The highest prevalence and intensity factor for pyrenophorosis in winter wheat plants sown after sunflower was in the variety Krasa Dona, with 47% prevalence and 0.63% intensity, and the lowest in the variety Niva Stavropolia, with 21% and 0.33%, respectively.
FROM IDEALISM TO NEW MARXISM. PART 3. BORIS ASAFIEV
Authors:   Russian State University for the Humanities, Markov Alexander V.
Published: February 2022

Although the merits of the major Soviet musicologist Boris Asafiev to the sociology of art are obvious, usually his system of studying melody and intonation as social phenomena is seen as a problematization of musical art rather than as a stimulus for his own thought. Using the example of Asafiev’s opera criticism from 1914 to 1947, I prove that his sociology of art was a constructivist system that focused on the permanence of implicit aesthetic notions such as manner and style, while allowing for variability in the explicit reference concepts of criticism. The ideological pressure to construct national character and the historical unity of popular life allowed him to reinterpret studio opera as a way of isolating its supra-personal principles, and by asserting the historical and transitory nature of opera art, to protect its sustained rhetorical potential. The unity of the rhetorical and melodic elements of opera, declared by Asafiev to support the work of Prokofiev and Shostakovich, was the dynamic formula that led to the development of a new sociology of art, which can be compared with the current actor-network models.
Efectos de la experiencia cultural en la percepción de excelencia e impacto económico de los asistentes al Festival Internacional Cervantino
Authors: González-Rosas Erika Lourdes , Cárcamo-Solis María de Lourdes , Navarrete-Reynoso Ramón
Published: February 2022

El Festival Internacional Cervantino (FIC) es el evento turístico cultural más importante de la ciudad de Guanajuato, que atrae cada año a miles de visitantes. El objetivo de esta investigación fue determinar los factores que forman la experiencia de los asistentes al FIC, así como su relación con la percepción de la excelencia y del impacto económico, mediante la adaptación de un modelo estructural teórico basado en el modelo escandinavo de “Skot-Hansen y Linko y Silvanto”. Se empleó una metodología cuantitativa, sustentada en un modelo de ecuaciones estructurales, basado en una encuesta hecha de manera no aleatoria por conveniencia a 709 visitantes en 2017. Los resultados identificaron que los factores ilustración, empoderamiento y entretenimiento, provocaron en los asistentes del festival, una experiencia memorable que anima, profundiza y enaltece de forma significativa sus vidas, aspecto que no siempre se ha valorado en este tipo de actividades. Además, la experiencia influye en la excelencia apreciada, impactando en la percepción de la calidad y profesionalismo de la organización y el nivel artístico del FIC. Los asistentes de este festival también percibieron que la excelencia apreciada en los factores de ilustración, empoderamiento y entretenimiento, beneficia la imagen positiva de Guanajuato; al fortalecerla como destino turístico, lo que repercute económicamente. Se concluye que el FIC logra buenas prácticas y políticas culturales, lo que es arduo de alcanzar y puede ser un argumento a favor de su propuesta.
PENGARUH GREEN INNOVATION DAN KINERJA KEUANGAN PADA COMPETITIVE ADVANTAGE DAN NILAI PERUSAHAAN TAHUN 2015-2020
Authors: Putri Fabiola Vera , Khusnah Hidayatul
Published: February 2022

This study aims to test Green Innovation and Financial Performance on Competitive Advantage and Firm Value in manufacturing companies. This study uses secondary data, where secondary data is data obtained from the annual financial statements listed on the IDX during the 2015-2020 period. The sample in this study were 37 companies. In this study using purposive sampling method and in analyzing data using the WarpPLS 6.0 application. The results of the analysis show that Green Innovation has a positive and significant effect on Competitive Advantage. Meanwhile, Green Innovation has no effect on company value. Green Innovation has a positive and significant effect on financial performance. Meanwhile, Competitive Advantage has a negative and significant effect on financial performance. And financial performance has a positive and significant effect on firm value.
Detection of Essential Thrombocythemia based on Platelet Count using Channel Area Thresholding
Authors: Destarianto Prawidya , Noviana Ainun Nurkharima , Fitri Zilvanhisna Emka , Imron Arizal Mujibtamala Nanda
Published: February 2022

Essential Thrombocythemia is one of the Myeloproliferative Neoplasms Syndrome where the mutation of the JAK2V617F gene causes the bone marrow to produce excessive platelets. For early detection of Essential Thrombocythemia disease using a full blood count and peripheral blood smear examination. The main characteristic is that giant platelets are found as large as young lymphocytes with a number of more than 21 cells in one field of view. The purpose of this research is to detect Essential Thrombocythemia by counting the number of platelets in the peripheral blood smear image. This research utilizes computer vision technique where the research stages consist of peripheral blood smear image, color conversion, image enhancement, segmentation, labeling process, feature extraction and K-Nearest Neighbor classification. There are three features used, namely the number of platelet cells, area and perimeter. The K-Nearest Neighbor method is able to classify 215 training data with an accuracy of 98.13% and classify 40 testing data with an accuracy of 100% based on the value of K = 3.
Prediksi Harga Saham Menggunakan BiLSTM dengan Faktor Sentimen Publik
Authors: Afrianto Nurdi , Fudholi Dhomas Hatta , Rani Septia
Published: February 2022

Stock market is one economic driver. It has roles in growth and development of a country. Stock is an attractive investment due to the huge profit. Many people buy and sell their stock. Stock investors try to choose the good investment company to get profits with small risk. Therefore, stock investors need to be careful and must evaluate a company. With machine learning technology, stock prediction problems can be solved. Deep learning is a subset of machine learning with own network. Deep learning has good performance in managing large amounts of data. This study used stock price history data and public sentiment data on a company. The method used in this research is Bidirectional Long-Short Term Memory (BiLSTM). The features used were closing price and compound score value of the public sentiment. Four scenarios were used in finding the best predictive model. The four scenarios use the same test data with different lengths of training data window. From the modelling, predictions with the model built using BiLSTM resulted in the smallest MSE value of 0.094 and the smallest RMSE value of 0.306.
E-commerce Recommender System Using PCA and K-Means Clustering
Authors: Andra Dendy , Baizal Abdurahman Baizal
Published: February 2022

Recently, recommender system has an important role in e-commerce to market products for users. One of recommender system approach that used in e-commerce is Collaborative Filtering. This system works by providing product recommendations based on products liked by other users who have similar preferences. However, sparse conditions in user data will cause sparsity problems, namely the system is difficult to provide recommendations because of the lack of important information needed. Therefore, we propose an e-commerce product recommendation system based on Collaborative Filtering using Principal Component Analysis (PCA) and K-Means Clustering. K-Means is used to overcome sparsity problems and to form user clusters to reduce the amount of data that needs to be processed. While PCA is used to reduce data dimensions and improve clustering performance of K-Means. The test results using the sports product dataset on the Olist e-commerce show that the proposed system has a lower RMSE value compared to other methods. For the number of neighbors of 10, 20, 30, and 40, our system obtains values of 0.771806, 0.75747, 0.75304, 0.75304, and 0.75270.
CLINICAL IMAGE QUALITY EVALUATION OF MAMMOGRAPHY FOR BREAST CANCER SCREENING
Authors: Cabero Flávia Vidal , Freitas-Junior Ruffo , Corrêa Rosângela da Silveira , Rodrigues Danielle Cristina Netto , Soares Leonardo Ribeiro , Freitas Paola Ferreira de
Published: February 2022

Objectives: To evaluate mammographic image quality in a real clinical practice scenario for breast cancer screening. Materials and Methods: Observational prospective study where images from digital mammograms from Diagnostic Service (DS) in the state of Goiás in 2019 were analyzed. A specific protocol was created based on evaluation criteria of the Brazilian College of Radiology, European Guidelines, and American College of Radiology. For each variable, score 1 was attributed to conformity and zero for nonconformity. Logistic regression model was utilized using the following independent variables: location (city vs. country), Public health system – Sistema Unico de Saude (SUS) (public vs. private), number of monthly examinations (≤300 vs. >300), device manufacturing year (≤2011 vs. >2011), and breast density (≤75% vs. >75% of the parenchyma). Results: Of the 163 fully functioning mammograms, 151 (92.6%) were eligible, providing 1,024 images. We evaluated 12,032 items, of which 4,096 were craniocaudal projections, 4,608 mediolateral oblique projections, and 3,328 equipment related. On the clinical image analysis as to the positioning of the patient, the higher conformity for symmetry parameters, in both projections (>90%), was observed. The conformity rate among the other parameters varied from 18.6% to 100%. In the multivariable analysis, it was observed that only the variables monthly examinations (OR 3.44; 95%CI 1.67–7.09; p=0.0008) and mammogram device manufacturing year (OR 2.46; 95%CI 1.02–5.95; p=0.04) were related to a higher conformity rate. After the percentage consolidation conformity rate per DS, as to the final clinical mammography quality, no DS presented desirable conformity (>90%), 20 DS obtained acceptable conformity (between 70% and 89%), and 10 DS presented conformity below 70%. Conclusion: Conformity rate of mammographic examination is extremely low and varies according to the multiple parameters analyzed. Mammographies performed at centers with less productivity (≤300/monthly) and with newer devices (>2,011) presented higher chances of conformity at the clinical imaging evaluation.
SURVEY OF BREAST CANCER CASES: PATIENTS WHO OBTAINED A COMPLETE PATHOLOGICAL RESPONSE AFTER NEOADJUVANT CHEMOTHERAPY AT THE CANCER INSTITUTE DR. ARNALDO VIEIRA DE CARVALHO IN THE YEARS 2013 AND 2014
Authors: Rodrigues Fábio Francisco de Oliveira , Barros Rebeca Belleza Ramacharaka , Pinheiro Lethicia Borges , Fristachi Carlos Elias , Carvalho Rodrigo Macedo de , Izar Ana Carolina Tretini , Bastos Etienne de Albuquerque , Borges Vinicius Miranda
Published: February 2022

Neoadjuvant treatment in breast cancer has some advantages, in that the treatment of micrometastatic disease has increased because of the higher degree of performing conservative surgery and reducing tumor burden. The complete pathological response (CPR) is defined as the absence of invasive carcinoma in the anatomopathological study of breast tissue and axillary lymph nodes. The aim of this study is to analyze patients diagnosed with breast cancer between the years 2013 and 2014, taking into account the following variables: age, chemotherapy (type of medication and duration), CPR, and histological subtypes. Medical records were analyzed. Of 31 patients who underwent neoadjuvant chemotherapy, three obtained a CPR. Of these, two had hybrid HER2 histological subtype, one negative triple, and one Luminal A. Method: A study was conducted in which the eligible population was composed of women diagnosed with breast cancer (cid c50) whose treatment and follow-up was performed by the mastology team of the Dr. Arnaldo Cancer Institute. Patients who were diagnosed from 2013 to 2014 were selected. For the description of the cases, variables such as tumor subtype, age, Qt neo performance, and CPR were analyzed. Clinical and pathological characteristics were collected regarding diagnosis and type of treatment, laterality, tumor staging, and the number of compromised lymph nodes. Subsequently, the response to the end of the first treatment — Qt neo, a classification, was performed: no evidence of the disease, partial remission, disease in progression, death, or CPR. Results: We evaluated 163 patients diagnosed with breast cancer between 2013 and 2014 at the Dr. Arnaldo Cancer Institute and also included 31 patients who underwent Qt neo. It was observed that of these three had CPR, 68 were older than 60 years and the most common histological type was invasive ductal carcinoma.
EFFECTS OF RESISTANCE TRAINING ON MUSCLE STRENGTH, BODY COMPOSITION, AND ANXIETY IN BREAST CANCER SURVIVORS
Authors: Siqueira Gabriel , Santos Wanderson , Siqueira Luane , Pereira Naiany , Gomes Ellen , Vieira Carlos
Published: February 2022

Objective: The aim of this study is to compare the effects of resistance training (RT) on muscle strength (MS), body composition (BC), and anxiety indicators in eutrophic, overweight, and obese breast cancer survivors (BCS). Methodology: Twentysix BCS women (56.07±6.94 years old; body mass index [BMI]: 68.29±11.18 kg), who were undergoing hormone therapy, performed 8 weeks of RT once a week. The BCS were divided into three groups as follows: eutrophic (BMI ≤ 24.4 [23.72±1.41], n=9), overweight (BMI 25–29.9 [27.21±1.26], n=9), and obese (BMI ≥ 30 [33.37±2.06], n=8). For the MS, the 10-repetition maximum test (normalized 10-RM/BM) on the bench press (BP) and the leg press (LP); for BC, the dual-energy X-ray absorptiometry; and for anxiety, the state-trait anxiety inventory were performed. For overtime analysis, the paired t-test for MS and BC and the Wilcoxon test for anxiety indicators were conducted. For analyses between groups, the mean difference (∆ [post-baseline]) was calculated using the one-way analysis of variance for MS and BC and the Kruskal– Wallis test for anxiety indicators. Results: There were no differences between the groups. All groups improved on the BP (p≤0.001) and the LP (p<0.001) overtime (eutrophic [BP, ∆=0.050±0.03; LP, ∆=0.401±0.10], overweight [BP, ∆=0.069±0.03; LP, ∆=0.406±0.15], and obese [BP, ∆=0.037±0.02; LP, ∆=0.375±0.11]). In the BC analyses, it was verified and improved only for the eutrophic BCS in the fat percentage (∆=-1.122±1.11, p=0.016) and lean mass (∆=0.650±0.78, p=0.036). There was a significant reduction in the state-trait anxiety in the eutrophic (∆=-7.444±8.13, p=0.030) and obese (∆=-9.125±9.70, p=0.042) groups. Conclusions: All BCS groups improved their MS. The eutrophic BCS may have a better response in BC compared with overweight and obese BCS. With regard to state-trait anxiety, the eutrophic and obese BCS groups showed better response than the overweight BCS group. The results suggest that the eutrophic BCS can present improvements in more components with a weekly session of RT; however, further studies should be performed.