bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis PIECES Pada Aplikasi WebGIS Pemetaan Ekonomi Kreatif (Ekraf)
Authors: Hetty Meileni  , Oktapriandi Sony , Apriyanti Desi
Published: November 2020

Ekonomi kreatif (Ekraf) merupakan salah satu faktor utama dalam peningkatan perekonomian. Ekonomi kreatif sering dikenal dengan istilah industri kreatif yang merupakan realisasi dari kreativitas dan keterampilan individu. Perkembangan ekonomi kreatif yang begitu pesat menciptakan sinergi yang tak terpisahkan dengan UKM (Usaha Kecil Menengah). Propinsi Sumatera Selatan memiliki ekonomi kreatif yang dapat dijadikan andalan, sektor fasyen dan kuliner menjadi andalan utama dalam peningkatan ekonomi. Ekraf dan UKM merupakan kekuatan tersendiri dalam menggerakan roda perekonomian daerah. Berdasarkan data yang didapat dari Badan Pusat Statistik tahun 2016 jumlah usaha Ekraf yang ada di Propinsi Sumatera Selatan berjumlah 156.322 dan saat ini Pemerintah Propinsi Sumatera Selatan belum mempunyai sebuah sistem atau aplikasi yang dapat digunakan untuk memetakan semua sektor ekonomi kreatif yang ada. Untuk melakukan pemetaan Ekraf yang ada perlu dibuat aplikasi pemetaan Ekraf di Propinsi Sumatera Selatan. Agar aplikasi ini dapat diimplementasikan secara maksimal dan terhindar dari kesalahan baik program maupun aplikasinya, maka perlu dibuat analisis dengan menggunakan metode PIECES sehingga aplikasi ini dapat diterapkan pada Dinas Perindustrian Sumatera Selatan dan dapat digunakan oleh masyarakat umum terkait perkembangan Ekraf yang ada di Propinsi sumatera selatan.
Hubungan Variabel Pemasaran Digital Terhadap Electronic Word Of Mouth (E-WOM): Sebuah Studi Literatur
Authors: Hariyanti Novi Tri , Trianto Edwin Meinardi , Wirapraja Alexander
Published: November 2020

Pemasaran adalah bidang keilmuan yang menarik dan dilengkapi dengan aspek digital menjadikan pemasaran digital sebagai salah satu bidang keilmuan yang memiliki cakupan yang sangat besar, terlebih dengan mengaitkannya kepada keterlibatan konsumen. Pada penelitian terdahulu didapatkan variabel-variabel penelitian yang digunakan untuk mengukur kepuasan dari konsumen, maka dengan menggunakan metode penelitian studi literatur peneliti menemukan variabel-variabel yang dianggap dapat digunakan untuk mengukur persepsi konsumen dari sisi kualitas website, kepuasan dan keinginan konsumen untuk berbagi dengan konsumen lainnya, dengan memanfaatkan literatur ilmiah antara rentang waktu tahun 2015-2020. Hasil pemetaan literatur yang dilakukan didapatkan hasil bahwa variabel yang secara umum digunakan dalam penelitian pemasaran digital adalah kualitas website untuk mengukur kehandalan dari situs, kepuasan konsumen yang diungkapkan secara elektronik (e-satisfaction), kualitas informasi yang diberikan oleh situs dan keinginan konsumen untuk berbagi pengalaman pengunaannya kepada konsumen lain (E-WOM). Selain variabel didapatkan pula metode yang sering digunakan dalam penelitian pemasaran digital adalah menggunakan metode kuantitatif dengan pendekatan Structural Equation Modelling (SEM).
Holy War and a Place in Paradise? Development of the East Roman Holy War from the 4th until the 11th century
Authors: SYVÄNNE Ilkka
Published: November 2020

The article analyses the development of the holy war in East Rome from its beginning until the 11th century. The article takes the stance that it is meaningless what the official religious doctrine was when the soldiers themselves believed and followed the doctrine of holy war which promised a place in heaven for all fallen soldiers.
Historical Metal works named Warsaw in Iran
Authors: KARAMIAN Gholamreza
Published: November 2020

Since long times ago, the artists of Lorestan, have been earning their livelihood through making various types of handicraft a valuable art piece deeply rooted in the province’s history called nickel silver crafts. In Farsi, varsho is actually the word ‘War-saw’. What is the reason for such labeling of these works of art in the Qajar and Pahlavi periods in Iran? Lorestan artists in Borujerd town created such magnificent art at that time. We still don’t know the reason for this naming, but one thing is clear, such metalwork is part of the history of art in both Poland and Iran.
Sprawozdanie z konferencji naukowej „Wojsko Polskie na wschodnich rubieżach Rzeczypospolitej – historia i współczesne wyzwania” (Siedlce, 4-5 września 2019 r.)
Authors: MADEJ Anna
Published: November 2020

A report on the scientific conference ‘Polish Army on the eastern frontiers of Poland – history and modern challenges’, which was held in Siedlce on 4th-5th September 2019.
MEMBANGUN KETAHANAN RELEGIUS ANAK MELALUI ACTIVE PARENTAL INVOLVEMENT
Authors: Bin-Tahir Saidna Zulfiqar
Published: November 2020

The objectives of this study were to 1) determine the behavior of parents in educating children's religiosity; 2) identify children's actions in applying religiosity in society. The location of this research is in Ubung Village, Lilialy District, Buru Regency, because this location is assessed as the role of parents in educating children's religiosity very high and intensively. This research is a qualitative descriptive study. The method in this research is the method of observation with data collection techniques used, namely in-depth interviews, observation, and documentation. The sampling technique used was purposive sampling technique. The results showed 1) parental behavior in educating religiosity in the village of Ubung includes (1) democratic parenting or behavior. In this pattern there are four aspects applied by parents in Ubung Village, namely (a) aspects of affection, (b) aspects of communication, (c) aspects of self-control, (d) aspects of maturity demands; (2) permissive parenting; (3) attachment parenting; (4) authoritarian parenting; (5) helicopter parenting; (6) negligent parenting. 2) As for the children's actions in implementing religiosity in the community in Ubung Village, namely looking happy and happy in their interactions, never learning to control their behavior, having a high sense of care for their surroundings, often less happy, withdrawn, afraid, and less confident When comparing themselves with others, children tend to be afraid of expressing opinions, low self-esteem, and so on.
ACADEMIC INTERACTION IN DISTANCE LEARNING (ON THE EXAMPLE OF STUDENTS-LINGUISTS)
Authors: Brim N.E.
Published: November 2020

The article deals with the problem of organizing distance learning academic interaction based on the provisions of a synergistic and personality-oriented approach to the educational interaction of teachers and students as a self-organizing and mutually enriching system. The effectiveness of this interaction is achieved by identifying and substantiating the relevant pedagogical conditions: pedagogical assistance and technical support, implemented in the structural components of the distance learning interaction program. The article describes the models of distance learning interaction and the algorithm of actions of its participants, draws attention to the selection of optimal educational resources: methods, forms and means of distance learning. The article also presents and analyzes the results of a survey of teachers of Udmurt State University and students-linguists studying a foreign language about the problem of distance learning; some facts from personal experience in this direction are presented. In conclusion, methodological recommendations in the organization of distance learning interaction are given.
Short-term Forecasting of Cumulative Confirmed Covid-19 Cases Pandemic in Somalia
Authors: Ali Dahir Abdi , Sani Muhammad
Published: November 2020

Somalia has recorded the first confirmed Covid-19 case and first death case on March 16, and April 08, 2020, respectively. Since its arrival, it had infected 2,603 people and took the lives of 88 people while 577 patients were recovered as of 14 June, 2020. To fight this pandemic, the government requires to make the necessary plans accordingly. To plan effectively, the government needs to answer this question: what will be the effect of Covid-19 cases in the country? To answer this question accurately and objectively, forecasting the spread of confirmed Covid-19 cases will be vital. To this regard, this paper provides real times forecasts of Covid-19 cases employing Holt's linear trend model without seasonality. Provided that the data employed is accurate and the past pattern of the disease will continue in the future, this model is powerful to produce real time forecasts in the future with some degree of uncertainty. With the help of these forecasts, the government can make evidence based decisions by utilizing the scarce resource available at its disposal.
Design and development of instant linear gel for coal bed methane gas operations
Authors: Murthy R. V. V. Ramana , Murthy K. S. R. , Chavali Murthy
Published: November 2020

Linear gel fracturing fluids are expressed with an extensive range of materials/polymers in an aqueous base. Earlier we developed fracturing linear gel with fossil diesel, bio-diesel and also used suspending anti-settling agents and emulsifiers. Here we report on a novel and an efficient method for the preparation of linear gel direct mix with water, guar gum and sodium acetate together instantly. In this research work, we used water instead of diesel without any need to mix anti-settling agents, suspending agents, emulsifiers that resulted in 30 viscosity linear gel. The degradation pattern observed from the breaker test showed that a reduction in gel viscosity depends on time, temperature & breaker concentration. Ammonium per sulphate or Ammonium per oxidisulphate and enzyme-G were used for oxidation purpose to break the gel gradually at a particular static temperature. Observations from experiments revealed that a small concentration of breaker provides rapid break compared to oxidative breakers. This article, designing of fracturing fluids describes how to use the fluid's viscosity generated by the gelling agents like guar gum for CBM operations.
A rajzó hadviselés és az osztott műveletek kialakulása
Authors: Kiss Roland
Published: November 2020

Az osztott műveletek egy korszerű hadviselési forma, amely azokra a harc­eljárásokra épít, amelyeket már a történelem kezdete óta használnak és jellemzőiket leg­jobban a rajzás foglalja össze. Hasonló az állatvilágban is megtalálható, így például a hangyák, méhek, darazsak, sakálok és farkasok között, amikor a boly, raj vagy falka egye­dei nagyobb területen tevékenykednek, de a zsákmányra vagy valamilyen fenyegetésre összpontosítanak, és azt több irányból támadják és küzdik le. A módszert a hadseregek a hadtörténelem kezdete óta egészen napjainkig alkalmazzák, bár jellege – elsősorban az alkalmazott technológia – folyamatosan változott. Az osztott műveletek alapja a rajzás, de tanulmányozása során a technológiai fejlődés hatásait, a jövő hadviselése szempont­jából különösen fontos elemeket, a hálózatalapúságot és a tűztámogató elemek átgon­doltabb és feladatra szabottabb alkalmazását érdemes inkább kiemelni. Jelen tanul­mány a rajzás és a műveleti koncepciók kialakulását tekinti át. Ismerteti a rajzás alapját képező rajintelligencia fogalmát, a rajzó harceljárásokat és azok mai alkalmazását.
Ludovikás hagyományok a Nemzeti Közszolgálati Egyetemen
Authors: Siposné Kecskeméthy Klára
Published: November 2020

A Nemzeti Közszolgálati Egyetem (NKE) létrehozása 2010-ben kezdődött. A tisztképzés rendszerének korszerűsítése során a honvédelmi miniszter 2010. július 1-jei hatállyal miniszteri biztost,1 a rektor jogkörében eljáró főtitkárt nevezett ki a Zrínyi Miklós Nemzetvédelmi Egyetem élére, valamint 2011. február 1-jén létrejött az MH Ludovika Zászlóalj. 2012. január 1-jén megalakult a Nemzeti Közszolgálati Egyetem, ezen belül a Hadtudományi és Honvédtisztképző Kar. A szerző tanulmányában részletesen áttekinti az egyetemnek otthont adó épületegyüttes átalakítását, felújítását, és láttatja, miként élnek tovább az egykori ludovikás hagyományok az új Ludovika Campuson.
Az önkéntes területvédelmi tartalékos alegységek ABV-védelmi feladatai
Authors: Csóka Attila
Published: November 2020

A Magyar Honvédség átalakította az önkéntes tartalékos rendszert. Olyan új meghatározások jelentek meg, mint önkéntes területvédelmi tartalékos, önkéntes műveleti tartalékos, illetve önkéntes védelmi tartalékos. Az önkéntes területvédelmi tartalékos századok Magyarország járásaiban szervezve lefedik az ország teljes területét. Interoperabilitásukat megkönnyíti, hogy elvileg azonos alapfelkészítésben részesülnek, így tervezhetően azonos elvárásokat lehet velük szemben támasztani. A különböző járások földrajzi elhelyezkedésükből és a települt ipari létesítmények jellemzőiből adódóan az alegységek eltérő kihívásokkal szembesülnek, ami a kötelékek szakosodását indokolhatja. Az írás összefoglalja az alegységeknek az erők megóvása érdekében teendő ABV-védelmi feladatait, bemutatja az önkéntes területvédelmi tartalékos katonák kiképzését, felhívja a figyelmet az eltérő kihívásokra, valamint vizsgálja a szakkiképzés esetleges szükségességét, különös figyelemmel az ABV-védelem területére.
Financial Factors Affecting Earnings Management and Earnings Quality: New Evidence from an Emerging Market
Authors: Saleh Isam , Afifa Malik Abu , Haniah Fadi
Published: November 2020

The purpose of this study is to examine the effect of financial factors on earnings management and earnings quality. Moreover, the study examines the role of earnings management as a mediator in the effect of the financial factors on earnings quality. It provides some empirical evidences from an emerging market, especially from the Jordanian market. The study uses a panel data analysis method over a ten-year period (2009-2018). The study population includes all Jordanian insurance companies listed in Jordanian market at the end of the year 2019, and the study sample consists of 20 Jordanian insurance companies (a complete population), giving a total of 200 observations for each variable. The results indicate that all financial factors in the model combined affect the earnings management and earnings quality. In addition, earnings management negatively affects earnings quality, and earnings management fully mediates the effect of financial factors on earnings quality. The study advises that policy makers ought to follow good legislation to curb the company's earnings management activities. Hence, the policy makers need to apply regulations which enrich the company’s effectiveness and efficiency whilst protecting the investors and other interested parties from risk.
ECOLOGICAL MARKETING AS A WAY OF ETHICAL PROMOTION AND POPULARIZATION OF GOODS AND SERVICES ON THE TERRITORY OF UKRAINE
Authors: Zakablukivska V. , Kalaida V.
Published: November 2020

The article provides a review of the essence of the concept of ecological marketing, its functions, approaches and methods of using. The importance of the role of the marketing concept of ecological marketing in the business activities of modern Ukrainian enterprises, the problems of implementation and formation of mechanisms for its implementation in the marketing activities of Ukrainian companies is emphasized.
Design And Polarization Scattering Characteristics Of L-Shape Reflector
Authors: Bai Xiaokai , Wang Zhanling
Published: November 2020

This paper presents a new L-shape reflector to enhance the cross-polarization radar cross section (RCS). Cross-polarization component can increase the jamming effect against the polarization radars. Such L-shape reflectors can also be used as radar tags in cars, books and so on for radar target detection. By bending the structure of traditional dipole reflector to L shape, the direction of surface current is changed, which produces the cross-polarization component.
Ambiguitas, Interkulturalitas, Dan Hibriditas Relasional Dalam Relasi Antara Israel Dan Bangsa-Bangsa Lain
Authors: Setio Robert
Published: November 2020

Abstrak: Artikel ini merupakan analisis terhadap hubungan antara Israel dan bangsa-bangsa lainnya dengan menggunakan pemikiran tentang “liyan.” Dalam masyarakat multikultural kehadiran liyan tidak terhindarkan dan menuntut tanggapan yang sungguh-sungguh. Keadaan ini pada gilirannya akan menciptakan ambiguitas, sebagaimana yang dialami oleh Israel. Penemuan arkeologis akhir-akhir ini membuktikan bahwa hubungan antara Israel dengan bangsa-bangsa lain ternyata tidak seperti yang dilukiskan oleh Alkitab. Israel bukanlah sebuah bangsa yang pada suatu masa datang ke Kanaan yang sudah berpenduduk, tetapi mereka muncul secara bertahap dari antara bangsa Kanaan sendiri. Maka, Israel memiliki banyak kesamaan dengan bangsa-bangsa lain itu. Pada pihak lain, Israel juga menumbuhkan sebuah ideologi yang lama-kelamaan akan membentuk mereka menjadi sebuah bangsa. Telah disarankan agar hubungan antara Israel dengan bangsa-bangsa lain itu dipandang sebagai hubungan interkultural. Meskipun pandangan itu masuk akal, namun penulis hendak mengajukan cara pandang lain. Cara pandang itu adalah hibriditas relasional. Dalam pandangan ini, Israel dilihat sebagai sebuah bangsa yang bersifat hibrid, namun bukan dalam arti yang statis. Hibriditas di sini dipandang sebagai sebuah keadaan yang menuntut tanggapan aktif. Dengan kata lain, kesamaan dan perbedaan antara Israel dengan bangsa-bangsa lainnya tidak boleh dianggap sebagai sebuah kondisi yang sudah jadi melainkan terus-menerus dalam proses pembentukan.

Kata-kata kunci: Liyan, ambiguitas, budaya, interkultural, agama, kesamaan, perbedaan, hibriditas relasional.

 

Abstract: This article will analyze the relationship between Israel and other nations using the concept of “the other.” In a multicultural society, the presence of the other is unavoidable and demands a serious response. This, however, creates ambiguity, as experienced by Israel. Recent archeological findings have proven that the relationship between Israel and other nations mentioned in the Bible was unlike the description provided by the Bible. Israel was not a separate nation that came into an already occupied land of Canaan, but rather, it gradually emerged as agroup from within the people of the land. Therefore, it can be expected that this nation shared many similarities with its cohabitants. On the other hand, it also developed a distinctive ideology which over time formed Israel as a separate nation. It has been suggested to consider the relationship between Israel and the others through the lens of interculturality. This article proposes another perspective, that is, a relational hybridity. From this perspective, Israel is seen as a hybrid nation. The hybridity is understood as a state of life, but, as one that always demands an active response. In other words, it is a process continously evolving.

Keywords: The other, ambiguity, intercultural, religion, similarity, difference, hybridity, relational
PENGARUH PENAMBAHAN ASAM BORAT (H3BO3) TERHADAP HASIL KARAKTERISASI NANOKRISTAL TiO2
Authors: Putama Mursal Iin Lidia
Published: November 2020

ABSTRAK

Telah dilakukan elektrodeposisi lapisan tipis nanokristal TiO2 dengan menggunakan larutan TiCl4 1,5 M. Karakterisasi SEM dan XRD yang digunakan mengindikasi terbentuknya nanokristal TiO2. Struktur Kristal TiO2 optimal didapat pada lapisan tipis TiO2 yang dielektrodeposisi dengan penambahan asam borat (H3BO3). Hasil SEM menunjukkan bahwa penggunaan CTAB menghasilkan morfologi permukaan yang merata, ukuran butir yang seragam dan terdistribusi hampir merata.

Kata kunci: Elektrodeposisi, asam borat (H3BO3), lapisan Tipis TiO2

ABSTRACT

TiO2 thin film nanocrytal was successfully prepared by electrodeposition method from TiCl4 solution 1,5 M. SEM and XRD characterization of electrodeposited films indicates the formation of TiO2 nanocrystal. The result showed that the optimal structure of TiO2 nanocrystal has been achieved by TiO2 thin film with borac acid (H3BO3). The optimal morphology was obtained by H3BO3 addition. It caused by the grain morphology showed homogenous morphology, grain size, and evenly distributed.

Keywords: Electrodeposition, borac acid (H3BO3),TiO2 nanocrystal
UJI EFEKTIVITAS ANTIDEPRESAN SUSPENSI EKSTRAK DAUN SIRSAK (Annona muricata, L.) TERHADAP MENCIT PUTIH JANTAN
Authors: Pradiningsih Anna , Zuniarto Ahmad Azrul , Maulana Ndang Ikbal
Published: November 2020

Abstract
ANALISIS HUBUNGAN FAKTOR RISIKO DENGAN KEJADIAN INTERAKSI OBAT POTENSIAL PASIEN GERIATRI DI RUMAH SAKIT SWASTA YOGYAKARTA
Authors: Arfania Maya
Published: November 2020

Abstrak

Dewasa ini populasi di Indonesia meningkat dengan pesat. Diprediksi Indonesia akan menduduki 10 besar tertinggi yang memiliki populasi berusia lebih dari 60 tahun, yaitu sebesar 54 per 1000 orang pada tahun 1980 dan 76 per 1000 orang pada tahun 2000. Kemungkinan proporsi lanjut usia akan mencapai 9,8% dari total populasi pada tahun 2010, bahkan peningkatannya dapat mencapai 3,7% antara tahun 2010 sampai 2020.

Penelitian ini adalah penelitian cross sectional, dimana pengambilan sampel dilakukan secara purposive random sampling. Jumlah sampel yang digunakan adalah sebesar 100 lembar resep. Setelah dilakukan analisis dengan menggunakan chi square diketahui bahwa dalam peneltiian ini, jenis kelamin dan jumlah obat bukanlah menjadi faktor risiko dari potensi terjadinya interaksi obat.

Kata kunci : geriatri, interaksi obat, penyakit kronis

Abstract

The population in Indonesia was increase rapidly nowadays. It is been predicted Indonesia will occupy the highest top 10 who has population over 60 years, wich is equal to 54 per 1000 people in 1980 and 76 per 1000 people in 2000. Itâ€™s possible that the proportion of elderly will reach 9,8% of total population in 2010, even the increase can reach 3,7% between 2010 and 2020. This study was a cross-sectional study, where the sampling was done by purposive random sampling. The number of samples is 100 recipes. After analyzed usig chi square, it was found that in this study, gender and the number of drugs were not the risk factor of potential drug interactions.

Keywords: geriatri, drug interaction, chronic disease
TELAAH FITOKIMIA EKSTRAK ETANOL DAUN JERUK PURUT (Citrus hystrix DC) DI KABUPATEN KARAWANG
Authors: Arfania Maya
Published: November 2020

Abstrak

Jeruk purut (Citrus hystrix DC.) merupakan salah satu keanekaragaman flora di Indonesia. Jeruk purut oleh masyarakat Indonesia dimanfaatkan sebagai penyedap masakan dan aroma terapi. Penelitian mengenai jeruk purut masih terbatas dilakukan dibandingkan ketersediaan jeruk purut di alam yang melimpah. Penelitian ini bertujuan untuk mengetahui kandungan metabolit sekunder ekstrak etanol daun jeruk purut yang terdiri dari flavonoid, alkaloid, polifenolat, kuinon, monoterpenoid dan seskuiterpenoid.

Penelitian ini dilakukan dengan metode ekstraksi kemudian dianalisis penapisan fitokimia simplisia daun jeruk purut secara kualitatif. Hasil penelitian menunjukkan ekstrak daun jeruk purut positif mengandung senyawa alkaloid, flavonoid, polifenolat, kuinon, monoterpenoid dan seskuiterpenoid.

Kata kunci : Daun citrus hystrix, ekstraksi, metabolit sekunder

Abstract

Lime (Citrus hystrix DC) is one of the flora diversity in Indonesia. Lime has been used as a seasoning and aromatherapy by Indonesian people. Research of lime still limited compared to lime availability which is very rich in the nature. The purpose of the research is to discover the content of ethanol extract of lime leaves which is consist of flavonoids, alkaloids, poliphenolics, quinone, monoterpenoin, and sesquiterpenoin.

The research is conducted with extraction method then the phytochemical screebning of lime leaves simplicia has been analyzed with qualitative methode. The result show that lime leeaves extract positively contain alkaloids, flavonoids, polyphenolics, quinone, monoterpenoid and sesquiterpenoid compound.

Keywords: Citrus hystrix leaves, extraction, secondary metabolite
ANALISIS PENGGUNAAN OBAT GASTROESOPHAGEAL REFLUX DISEASE (GERD) PADA PASIEN RAWAT JALAN DI RUMAH SAKIT UMUM DAERAH KARAWANG
Authors: Dedy Friyanto  , Siti Lestari
Published: November 2020

ABSTRAK

Gastroesophageal Reflux Disease (GERD) adalah suatu kondisi refluksnya HCL dari gaster ke esofagus, mengakibatkan gejala klinis dan komplikasi yang menurunkan kualitas hidup seseorang. Angka pravalensi di Indonesia dari tahun ke tahun meningkat yaitu sebanyak 25,18% pada tahun 2002, peningkatan ini terjadi akibat adanya perubahan gaya hidup yang dapat meningkatkan faktor risiko GERD seperti merokok dan minum kopi. Penelitian ini menggunakan rancangan penelitian analis kuantitatif untuk mengetahui angka kejadian, kerasionalan penggunaan obat dan faktor hubungan penyakit sedangkan kualitatif untuk mengetahui gambaran pola penggunaan obat dan karateristik pasien GERD dengan metode observasional. Hasil penelitian angka kejadian GERD di RSUD Karawang adalah 68 pasien, pada pasien perempuan lebih tinggi sebesar 51,5% (35 pasien) dan Kerasionalan terapi pada pasien GERD di RSUD Karawang menggunakan tiga literatur yaitu Pharmacotherapy Handbook, British National Formulary edition 70 dan Konsensus GERD di Indonesia edisi tahun 2013 diperoleh hasil rata-rata: tepat indikasi sebesar 80,4%, tepat obat sebesar 59,3%, tepat pasien sebesar 89,7% dan tepat dosis sebesar 64%. Pada analisis bivariat menggunakan analisis Kruskal Wallis nilai p sebesar 0,014 menunjukkan jenis kelamin adalah faktor resiko tanda dan gejala Gastroesophageal Reflux Disease (GERD).

 

Kata Kunci : Gastroesophageal Reflux Disease (GERD), Prevalensi, Rasionalitas terapi, Pasien Rawat Jalan.

 

ABSTRACT

Gastroesophageal Reflux Disease (GERD) is a condition of HCL reflux from gastric to esophagus, resulting in clinical symptoms and complications that reduce a person's quality of life. The pravalence rate in Indonesia has increased from year to year by as much as 25.18% in 2002, this increase is due to lifestyle changes that can increase GERD risk factors such as smoking and drinking coffee. This study uses a quantitative analyst research design to determine the incidence, rational use of drugs and disease relationship factors while qualitative to describe the pattern of drug use and characteristics of GERD patients with observational methods. The results of the study of the incidence of GERD in RSUD Karawang were 68 patients, in female patients higher by 51.5% (35 patients) and rationality of therapy in GERD patients in RSUD Karawang using three literature namely Pharmacotherapy Handbook, British National Formulary edition 70 and GERD Consensus in the 2013 edition of Indonesia the average results were obtained: the exact indication was 80.4%, the exact drug was 59.3%, the exact patient was 89.7% and the exact dose was 64%. In the bivariate analysis using the Kruskal Wallis analysis the p value of 0.014 indicates gender is a risk factor for signs and symptoms of Gastroesophageal Reflux Disease (GERD).

 

Keywords : Gastroesophageal Reflux Disease (GERD), Prevalence, Rationality of therapy, Outpatients.
PENGARUH VARIASI KONSENTRASI GELLING AGENT CARBOPOL 940 TERHADAP SIFAT FISIK SEDIAAN GEL HAND SANITIZER MINYAK ATSIRI DAUN KEMANGI (Ocimum Sanctum L.)
Authors: Iin Lidia Putama Mursal  , Anggun Hari Kusumawati  , Devi Hartianti Puspasari
Published: November 2020

ABSTRAK

Hand sanitizer adalah produk efektif dan murah yang dapat mengurangi mikroorganisme pada kulit. Banyak hand sanitizer yang mengandung etanol dan alkohol dengan kadar 60% -95% tetapi kandungan alkohol dalam hand sanitizer dapat menyebabkan resiko kesehatan. Penelitian ini bertujuan untuk melihat pengaruh gelling agent Carbopol 940 terhadap sifat fisik sediaan gel hand sanitizer. Konsentrasi yang digunakan untuk gelling agent Carbopol 940 yaitu 0,5%; 1%; 1,5%. Uji sifat fisik meliputi uji organoleptik, uji homogenitas, uji pH, uji viskositas, uji daya sebar dan uji daya lekat. Hasil penelitian sifat fisik sediaan gel hand sanitizer minyak atsiri daun kemangi yaitu peningkatan kadar gelling agent menyebabkan warna gel semakin pudar, wujud semakin kental, peningkatan viskositas, peningkatan daya lekat dan penurunan daya sebar. Berdasarkan uji sifat fisik sediaan gel hand sanitizer minyak atsiri daun kemangi dapat disimpulkan bahwa (F2) dengan konsentrasi 1% Carbopol 940 adalah formula optimal karena memenuhi semua persyaratan sifat fisik gel.

Kata kunci : gelling agent, carbopol 940, sifat fisik, Ocimum sanctum L.

 

ABSTRACT

Hand sanitizers were effective and inexpensive product that can reduce of microorganims on the skin. Many hand sanitizer have contents up to 60%-95% ethanol and isopropyl alcohol, but using alcohol in hand sanitizer can cause health risks effect. The aim of this work was to determine the effects of gelling agent Carbopol 940 on physical properties of formulation gel hand sanitizer. The concentration that used for the Carbopol 940 gelling agent are 0,5%; 1%; 1,5%. The test of physical properties includes organoleptic, homogeneity, pH, viscosity, dispersive ability, and adhesion The results of this research on the physical properties gel hand sanitizer of basil essensial oil, showed that the increasing of gelling agent consentrasion, makes the gel getting faded, more thicker, increase of viscosity, adhesion and decrease of dispersive ability. Based on the physical properties test, (F2) with 1% concentration of Carbopol 940 is the optimal formula it caused by it suitable all the parameters of the physical properties of gel.

Keywords : gelling agent, carbopol 940, physical properties, Ocimum sanctum L.
EVALUASI KUALITATIF PENGGUNAAN ANTIBIOTIK PADA PASIEN ANAK DENGAN METODE GYSSENS DI RSUD KARAWANG
Authors: Diany Astuti  , Yuli Nurhayati
Published: November 2020

ABSTRAK

            Peresepan antibiotik untuk pasien anak-anak paling banyak digunakan dalam terapi. Penggunaan Antibiotik untuk anak-anak harus diawasi dan dikendalikan karena penggunaan antibiotik yang tidak terkontrol dan tidak tepat dapat berdampak pada kegagalan efek terapi yang diharapkan dan kemungkinan dapat meyebabkan resistensi antimikroba.  Pemakaian antibiotik harus dianalisis untuk mengendalikan resistensi antibiotik.  Tujuan penelitian ini untuk menilai rasionalitas terapi antibiotik pada pasien anak. Penelitian ini merupakan analisis deskriptif retrospektif dengan pengambilan data purposive sampling. Subjek dari penelitian adalah rekam medis dari bangsal anak RSUD Karawang. Rasionalitas penggunaan antibiotik adalah penilaian melalui metode gyssens. 147 data dianalisis untuk penelitian ini terdiri dari anak laki-laki (54,40%) dan perempuan (45,60%) dengan kasus demam tifoid (53,10), diare (24,5%) dan bronkopneumonia (22,4%). Antibiotik yang digunakan sefotaksim (71,43%), amoksisilin (5,44%) dan kloramfenikol (4,76%). Penilaian antibiotik melalui metode Gyssens adalah skala IVA (93,20%), skala IIB (6,12%) dan skala IIIA (0,68%).

Kata Kunci: Antibiotik, Rasionalitas, Metode Gyssens.

 

ABSTRACT

            Antibiotics prescription for pediatric patients is most widely used in therapy. Antibiotic use for pediatric must be watched and controlled because uncontrolled and inappropriate use of antibiotic can impact on failure of expected therapeutic effect and can also cause the possibility of antimicrobial resistance. Antibiotic consumption is must analyzed for controlling the antibiotics resistance. The aim of study The aim of this study was to assess the rationality of antibiotic therapy in pediatric patients. This research is a retrospective descriptive analysis with purposive data sampling. Subject of study are medical record from pediatric ward in RSUD Karawang. Rationality used of antibiotic is asses through Gyssens method. 147 data was analyzed for this study consist of boys (54,40%) and girls (45,60%) with case of typhoid  fever (53,10), diarrhea (24,5%) and bronchopneumonia (22,4%). Antibiotic was use Cefotaxime (71,43%), Amoxicillin (5,44%), Chloramphenicol (4,76%)etc.  Assessment  antibiotic through Gyssens method are IVA scale (93,20%), IIB scale ( 6,12%) and IIIA scale (0,68%).

Keyword : Antibiotic, Rationality, Gyssens Method.
STATISTICAL ANALYSIS OF VERATRUM ACUTE POISONINGS DURING 2014-2018 IN MOSCOW, SAINT PETERSBURG, OMSK, CHITA, AND KHANTY-MANSIYSK AUTONOMOUS OKRUG – UGRA
Authors: Melnik E. V. , Belova M. V. , Lodyagin A. N. , Sabaev A. V. , Yatsinyuk B. B. , Afonkin I. A. , Tyurin I. A. , Ramenskaya G. V.
Published: November 2020

Acute hellebore poisoning is characteristic for the Russian Federation because of the use of this plant for the treatment of alcoholism at home. The varying severity of clinical symptoms, which sometimes become lifethreatening, the lack of anamnestic reliable information about the use of hellebore and the difficulties of chemical and toxicological confirmation of its use complicate the diagnosis of acute poisoning, and do not allow timely medical care. In addition, there is no classification of hellebore poisoning in ICD-10, block (T51-T65), which also affects the assessment of the actual frequency of this acute intoxication. The purpose of this work is to clarify the number of acute hellebore poisoning in the Russian Federation. The analysis of medical records of patients hospitalized with acute hellebore poisoning in toxicological departments of a number of subjects of the Russian Federation for 2014 - 2018 was carried out. The dynamics of such acute poisoning over the specified period, the gender and age composition of victims, and the circumstances of poisoning were revealed. The relevance of developing methods of chemical and toxicological analysis for the determination of hellebore alkaloids is confirmed, which will increase the reliability of diagnosis and detection of cases of hellebore poisoning.
DETERMINATION OF RICIN IN ENVIRONMENTAL SAMPLES USING BIOASSAY
Authors: Rogovskaya N. Yu. , Gorbunov A. Yu. , Dubrovskii Ya. A. , Khlebnikova N. S. , Babakov V. N.
Published: November 2020

A bioassay of ricin toxicity in environmental samples using real-time cell index monitoring is proposed. The halfmaximal inhibitory concentration (IC50) of ricin was estimated at 6,7 ng/ml for human hepatoma HepaRG cells proliferation. The antibodies to A- and B-subunits in HepaRG cell media lead to cytoprotective and antiapoptotic effects against the cytotoxicity of ricin. The antibodies neutralised activation of JNK kinase (phosphorylated at Thr183/Tyr185) and prevented accumulation of the active forms of caspase 8 (hydrolysed to Asp384) and caspase 9 (hydrolysed to Asp315) induced by ricin in HepaRG cells. The tested antibodies also prevented a decrease in the intracellular levels of the active forms of Akt 1 kinase (phosphorylated at Ser473) and transcription factor p53 (phosphorylated at Ser46) caused by ricin. The bioassay with antibodies can be considered as a specific method for identifying the toxin in environmental samples.
Kupfer, Klunker und Klamotten: Das Notizbuch des Schreibers Thutmose
Authors: Müller Matthias
Published: November 2020

Review article on the edition of P. Vienna ÄS 10321 by Regina Hölzl, Michael Neumann & Robert J. Demarée. The paper discusses the general contents of the entries relating mainly to transfers of copper. In addition, various issues regarding new or known lexical items are highlighted. Finally, a list with sundry observations to the edition ensues.
Risk estimation and decision making in management (in selected areas of science)
Authors: Galanc Tadeusz , Kołwzan Wiktor , Pieronek Jerzy , Skowronek-Grądziel Agnieszka
Published: November 2020

Risk is a category that is inseparably connected with uncertainty and probability, which means that the nature of risk as a category of science is complex, and the concept of risk is very difficult to define by one conceptual system of modern science. Due to the above, the main research hypothesis of the work is oriented to the assumption that the complexity of the risk category is determined by the diversity (variety) of reality, as a result of which in science there is currently no uniform methodology for risk assessment and estimation. As a result, the main goal of the article is to describe the research area based on selected representative methods of risk estimation and logical decision-making schemes, as well as to systematise the knowledge about the methodology used in them. In the article, the authors illustrate risk estimation with examples developed by themselves and quoted from various fields of science, differing from one another in formal terms in quantitative and qualitative (numerical and content-verbally) dimensions. Strategic risk, risk of fraction estimation, Bayesian risk, Bayesian methods for estimation of population distribution parameters, risk of econometric model assessment, interest rate risk, banking risk, and adverse event as a measure of risk are here addressed. The article also focuses on the problem of risk estimation in terms of the theory of fractals. The work is to have not only cognitive but also practical meaning. The created source of knowledge should prove helpful for decision-makers in the area of management since effective process management requires the expertise of risk estimation in various dimensions and using various mathematical tools.
EFFECTIVENESS EVALUATION OF REHABILITATION OF PATIENTS AFTER MICROSURGICAL DISCECTOMY ON THE LUMBAR SPINE IN CLINICAL SANATORIUM
Authors: Brekhov А. N. , Ponomarenko Уи. N. , Khashchuk А. V. , Kobets У. V. , Tkach А. V. , Malchenko А. G.
Published: November 2020

In the article was providedanalysis of the results of rehabilitation of patients after microsurgical discectomy on the lumbar spine. A comparative assessment was made with the control group for clinical symptoms and quality of life.
PREVENTION AND TREATMENT OF COMPARTMENT SYNDROME DURING CLOSED LOCKABLE INTRAMEDULLARY OSTEOSYNTHESIS OF SHIN BONES
Authors: Tkach A. V. , Тikhonenko A. А. , Andrianov М. V. , Brekhov А. N. , Kobets Уи. V. , Malchenko A. G. , Plotkin А. V. , Тikhonenko А. А. (Jr.)
Published: November 2020

The aim of our study: to make an analysis of the development of MGIS with closed reposition and tibial metal osteosynthesis with a rod, to formulate the basics of the prevention of the compartment syndrome, using preventive fasciotomy, closed and half-closed. Carrying out preventive fasciotomy shin of technological cuts for the implantation of the locking rod can prevent the development of MGIS. Carrying out preventive fasciotomy semi-shin of technological cuts for the synthesis of the tibia does not affect the functional and cosmetic results of treatment of fractures of the tibial shaft, but It will improve prognosis significantly. Because of reducing risks of compartment-syndrome developing.
Ethnomedicinal use value of the flora of the Hill “La Botica” used by the Andean
Community of Cachicadán - Perú
Authors: Alipio-Rodríguez Anavely , Mostacero-León José , Lopéz-Medina Eloy , De La Cruz-Castillo Anthony J , Gil-Rivero Armando Efraín
Published: November 2020

The present investigation was aimed at determining the value of ethnomedicinal use
that is given to the flora of the Hill "La Botica", by the Andean Community of
Cachicadán, Santiago de Chuco, Perú. 96 semi-structured interviews were applied,
following the “snowball” technique. Collections were made by botanical explorations.For
each of the species, family data, scientific and common name, part used, disease or
disease treated, location in UTM and use value index (IVU) were detailed. 48 species of
flora are used ethnobotanically by the Andean Community of Cachicadán, distributed in 46
genera and 26 families, of which they stand out for their number of species: Asteraceae
(10), Rosaceae (5) and Lamiaceae (3). Of these, 72% (35 species) are very important for
the cure or treatment of their diseases, according to their use value (IVU). In addition
the inhabitants of the Andean Community of Cachicadán, report suffering from 38 diseases
or ailments; grouped into 10 categories, where they prevail, those of the systems:
respiratory (FCI = 0.88), digestive and gastrointestinal (FCI = 0.85), reproductive (FCI
= 0.84), urinary (FCI = 0.84), nervous (FCI = 0.83), Musculoskeletal (FCI = 0.82),
cardiovascular (FCI = 0.82) and rituals (FCI = 0.81).
PROSPECTS OF COMBINING INTERLEUKIN-2 WITH IMMUNE CHECKPOINT INHIBITORS FOR CANCER THERAPY
Authors: Kiselevskiy Mikhail , Chikileva Irina , Zharkova O. , Ziganshina N. , Korolenkova Lyubov , Sitdikova Suriya
Published: November 2020

The review summarizes results of pre-clinical and clinical investigations of combination therapies with interleukin-2 and immune checkpoint inhibitors. It presents data of the current registered clinical trials of immune checkpoint combinations either with interleukin-2 or the cytokine-activated lymphocytes. The up-to-date experimental and preliminary clinical data evidence that such an immune therapy strategy is highly promising for cancer treatment.
HIGH-INTENSITY FOCUSED ULTRASOUND IN THE TREATMENT OF MALIGNANT AND BENIGN TUMORS
Authors: Bespalov Vladimir , Tochilnikov Grigoriy , Senchik Konstantin , Yermakova Yelena , Kovalevskaya Yelizaveta , Gafton Georgiy , Berkovich A.
Published: November 2020

The review article discusses the possibilities of using high-intensity focused ultrasound (HIFU) in oncology. The technical principles and features of HIFU ablation, a brief history of the development of HIFU therapy, the principles of HIFU therapy, the physical basis of the HIFU ablation method, and the mechanisms of antitumor action of HIFU therapy are presented. The results and benefits of HIFU therapy for various malignant and benign tumors are discussed.
PROGNOSTICATION OF THE RISK OF ERG’S LYMPH NODE METASTASIS FOR PATIENTS WITH EARLY GASTRIC CANCER, WHICH GOES BEYOND EXPANDED INDICATIONS FOR ENDOSCOPIC RESECTION
Authors: Mochalnikova Valeriya , Perevoshchikov Aleksandr , Malikhova Olga
Published: November 2020

Additional surgical operation with lymph dissection is necessary after early gastric cancer’s (ERG) endoscopic resection (ER) and if tumor’s characteristics exceed certain JGCA [1] extended ER indications. However, during the research of surgical material from patients, who have undergone not radical ER, regional lymphogenic metastatic spreading is detected in small number of cases [2, 3, 4, 5]. Considering the low risk of lymph node metastasis and this patients group’s survivability, the issue of additional surgical operation’s importance is still questionable. In our research, we formed a rule for determining a tactic to treat ERG with expanded indications. The research consisted of two stages. During the first stage, we selected 229 patients with expanded indications from a total group with ERG (404 patients). Considering the low mortality risk from progressing ERG (14,4%, 33/229) during 10 years of observation (observation time median = 132 months), and using multi-dimensional logical analysis, we developed a regression equation to measure the risk of ERG’s lymph node metastasis amongst this category of patients. During the second stage, we divided 229 patients into 2 groups - with low and high risk of ERG’s lymph node metastasis - using the regression equation. The level of metastasis correlates with indications of tumor-specific survivability and survivability without indications of progression. The frequency of correct predictions is 83, %.
LATE ANASTOMOTIC LEAKAGE AFTER ANTERIOR RESECTION OF THE RECTUM
Authors: Kit Oleg , Gevorkyan Yuriy , Soldatkina Natalya , Kharagezov Dmitriy , Dashkov Andrey , Milakin Anton , Ilchenko Sergey , Kaymakchi Dmitriy
Published: November 2020

We analyzed literature data and our results of treatment of 37 patients with cancer of the middle and lower rectal ampulla (Т2-4аN0-2М0) who underwent low anterior resection of the rectum with colorectal anastomosis. The purpose of the study was to reveal characteristics of late colorectal anastomotic leakage. The results demonstrated differences in the clinical course of early and late colorectal anastomotic leakage, the site of anastomotic defect, anastomosis characteristics and the need for repeat surgery. There were some pathogenetic aspects distinguishing early and late anastomotic leakage, such as technical problems in early leakage and association with preoperative radiotherapy in late anastomotic leakage. Conclusions: timely diagnostics of microleakage of colorectal anastomosis will allow changing the further tactics of the patient management and avoiding the manifestation of late anastomotic leakage.
REPEATED CRANIOSPINAL IRRADIATION IN PATIENTS WITH RECURRENCE OF MEDULLOBLASTOMA
Authors: Trunin Yuriy , Golanov Andrey , Antipina A. , Ryzhova Marina , Absalyamova Oksana , Zagirov R. , Cherkesov I.
Published: November 2020

Medulloblastoma is the most common malignant CNS tumor in children, which occurs in the posterior cranial fossa and has a high risk of metastasis along the cerebrospinal fluid. A modern approach to treatment for patients older than 3 years includes the removal of the tumor with mandatory postoperative craniospinal irradiation with “boost” on the postoperative bed, followed by chemotherapy with platinum-containing drugs, which allows reaching a level of 80% for 5-year progression-free survival. In case of recurrence of the disease, the prognosis remains unfavorable. With multiple recurrence of supra-sub tentorial localization, it may be necessary to conduct repeated craniospinal irradiation. In this work, we considered the possibility of repeated craniospinal irradiation, which in some cases, subject to the use of modern radiation therapy techniques with a high degree of conformity, can be an effective form of treatment for multiple relapses of meduloblastoma with an acceptable level of toxicity.
THE MODERN ASPECTS OF THE BREAST CONSERVING SURGERY AFTER NEOADJUVANT CHEMOTHERAPY IN PATIENTS WITH BREAST CANCER CT1-3N0-3M0
Authors: Volchenko Nadezhda , Bosieva A. , Zikiryakhodzhayev A. , Ermoshchenkova M.
Published: November 2020

Introduction. While the “no tumor on ink” approach is generally accepted for breast-conserving surgery (BCS) in patient with breast cancer, it remains unclear whether it is oncologically safe for BCS after neoadjuvant chemotherapy therapy (NACT). The aim of the study is to investigate the optimal width of the resection edges in BCS after NALT and the influence on disease-free and overall survival in patients with breast cancer. Materials and methods. Retrospectively, the medical documentation of 76 patients with breast cancer, who were performed BCS after NACT, was studied. The distribution by stage of breast cancer was as follows: I St. -5 patients, II St. - 55, III St. - 16 (excluded IIIB St.). Invasive cancer of non-specific type was diagnosed in 81.6% of cases, in 6.5% - lobular cancer, in 1.3% - combined breast cancer. Radical breast resections in the classic version were performed in 28 cases, and oncoplastic resections in various modifications were performed in 48 Cases. Results. We present the retrospective data of 76 patients with breast cancer who underwent OSA after NALT in the Department of breast and skin cancer OF the Moscow Institute of medical research. P. A. Herzen. The results of our study demonstrated the oncological safety of OSO with respect to new sizes of tumor nodes after NALT followed by remote radiotherapy. The method of “absence of tumor cells” at the edges of resection demonstrated a high percentage of 1, 3, 5-year relapse - free and overall survival, the frequency of relapse was 2.6%. There was no statistically significant difference in 1, 3, 5-year relapse-free and overall survival when the width of the resection edges was more or less than 1 mm. Conclusion. The results of numerous studies have demonstrated that the breast- conserving surgery is the safe method of surgical treatment from an oncological point of view and is an alternative for radical mastectomies for patients with the breast cancer after neoadjuvant chemotherapy.