bluuebunny/crossref_metadata_2025 huggingface dataset:
Bridging the Gap between Theoretical Learning and Practical Application: A Qualitative Study in the Italian Educational Context
Authors: Fantinelli Stefania , Cortini Michela , Di Fiore Teresa , Iervese Stefano , Galanti Teresa
Published: February 2024

In the contemporary educational landscape, there is a growing recognition of the transformative impact of practical experiences within traditional learning frameworks. This shift reflects a pedagogical evolution that values contextualized learning and the acquisition of practical skills together with theoretical knowledge. In the Italian educational context, School–Work Alternation (SWA) represents a proactive response to the evolving needs of the workforce and the imperative for educational institutions to prepare students for professional life. This study’s objectives include a deep exploration of students’ SWA experience, evaluating its impact on employability perceptions and the sense of agency, examining the influence of Self-Orientation, and contributing insights to the discourse on integrating practical experiences in education. Employing a mixed methodology and a bottom-up approach, 63 high school students of different Italian regions participated in an online in-depth interview and an ad hoc questionnaire designed to measure the experience of SWA in relation to variables of interest, utility, advantage, perception of support, quality of received mentoring, engagement, and satisfaction. The quantitative results indicate that personal choice significantly influences the perceived usefulness of and satisfaction with SWA, with those students guided by curiosity exhibiting higher utility and satisfaction. Qualitative analysis underscores both positive and negative aspects, with respondents viewing SWA as a useful experience bridging work, corporate, and school realms provided that students are key players in the SWA experience’s choice and that the SWA’s partners are motivated to guide them in this practical training. Moreover, results highlight SWA’s relevance in guiding academic and career paths, emphasizing its potential to offer valuable support to students. This study contributes nuanced insights into integrating practical experiences in education, offering recommendations for educators and policymakers to better prepare students for the dynamic demands of the modern job market.
Motivational Climate, Physical Self-Concept, and Social Relationships in Adolescents in Physical Education Classes: A Systematic Review
Authors: Flores-Piñero María del Carmen , Valdivia-Moral Pedro , Ramos-Mondejar Luis , González-Hernández Juan
Published: February 2024

The aim of the present study was to provide a comprehensive summary of scientific evidence related with the influence on physical self-concept and prosocial behaviours in adolescents, taking into account the motivational climate generated in Physical Education classes by the teacher. Studies with similar samples have shown that special consideration must be given to the motivational climate of involvement with the task and the coach’s style in support of autonomy in a greater occurrence of prosocial behaviours in the sports context, which shows that the social context is the most important variable in the direction of moral behaviours. Following the application of a search protocol in the Web of Science (WoS) database, 131 articles were initially identified, with eight manuscripts finally being analysed according to previously established criteria for the various stages of the PRISMA checklist. Despite only a relatively small number of articles being available to have rigorously evaluated the topic of interest, analysed studies revealed a direct relationship between motivational climate and physical self-concept. In contrast, no relationship emerged with prosocial behaviour.
A Method for Unseen Object Six Degrees of Freedom Pose Estimation Based on Segment Anything Model and Hybrid Distance Optimization
Authors: Xin Li , Lin Hu , Liu Xinjun , Wang Shiyu
Published: February 2024

Six degrees of freedom pose estimation technology constitutes the cornerstone for precise robotic control and similar tasks. Addressing the limitations of current 6-DoF pose estimation methods in handling object occlusions and unknown objects, we have developed a novel two-stage 6-DoF pose estimation method that integrates RGB-D data with CAD models. Initially, targeting high-quality zero-shot object instance segmentation tasks, we innovated the CAE-SAM model based on the SAM framework. In addressing the SAM model’s boundary blur, mask voids, and over-segmentation issues, this paper introduces innovative strategies such as local spatial-feature-enhancement modules, global context markers, and a bounding box generator. Subsequently, we proposed a registration method optimized through a hybrid distance metric to diminish the dependency of point cloud registration algorithms on sensitive hyperparameters. Experimental results on the HQSeg-44K dataset substantiate the notable improvements in instance segmentation accuracy and robustness rendered by the CAE-SAM model. Moreover, the efficacy of this two-stage method is further corroborated using a 6-DoF pose dataset of workpieces constructed with CloudCompare and RealSense. For unseen targets, the ADD metric achieved 2.973 mm, and the ADD-S metric reached 1.472 mm. This paper significantly enhances pose estimation performance and streamlines the algorithm’s deployment and maintenance procedures.
Enhancing Energy Efficiency in IoT-NDN via Parameter Optimization
Authors: Papenfuß Dennis , Gerlach Bennet , Fischer Stefan , Hail Mohamed Ahmed
Published: February 2024

The IoT encompasses objects, sensors, and everyday items not typically considered computers. IoT devices are subject to severe energy, memory, and computation power constraints. Employing NDN for the IoT is a recent approach to accommodate these issues. To gain a deeper insight into how different network parameters affect energy consumption, analyzing a range of parameters using hyperparameter optimization seems reasonable. The experiments from this work’s ndnSIM-based hyperparameter setup indicate that the data packet size has the most significant impact on energy consumption, followed by the caching scheme, caching strategy, and finally, the forwarding strategy. The energy footprint of these parameters is orders of magnitude apart. Surprisingly, the packet request sequence influences the caching parameters’ energy footprint more than the graph size and topology. Regarding energy consumption, the results indicate that data compression may be more relevant than expected, and caching may be more significant than the forwarding strategy. The framework for ndnSIM developed in this work can be used to simulate NDN networks more efficiently. Furthermore, the work presents a valuable basis for further research on the effect of specific parameter combinations not examined before.
The El Niño Southern Oscillation Recharge Oscillator with the Stochastic Forcing of Long-Term Memory
Authors: Li Xiaofeng , Li Yaokun
Published: February 2024

The influence of the fast-varying variables that have a long-term memory on the El Niño Southern Oscillation (ENSO) is investigated by adding a fractional Ornstein–Uhlenbeck (FOU) process stochastic noise on the simple recharge oscillator (RO) model. The FOU process noise converges to zero very slowly with a negative power law. The corresponding non-zero ensemble mean during the integration period can exert a pronounced influence on the ensemble-mean dynamics of the RO model. The state-dependent noise, also called the multiplicative noise, can present its influence by reducing the relaxation coefficient and by introducing periodic external forcing. The decreasing relaxation coefficient can enhance the oscillation amplitude and shorten the oscillation period. The forced frequency is close to the natural frequency. The two mechanisms together can further amplify the amplitude and shorten the period, compared with the state-independent noise or additive noise, which only exhibits its influence by introducing non-periodic external forcing. These two mechanisms explicitly elucidate the influence of the stochastic forcing on the ensemble-mean dynamics of the RO model. It provides comprehensive knowledge to better understand the interaction between the fast-varying stochastic forcing and the slow-varying deterministic system and deserves further investigation.
Effectiveness of a Remote Monitoring-Based Home Training System for Preventing Frailty in Older Adults in Japan: A Preliminary Randomized Controlled Trial
Authors: Suzuki Yasuhiro , Shimizu Yukiyo , Soma Yuichiro , Matsuda Takaaki , Hada Yasushi , Koda Masao
Published: February 2024

This study examined whether SUKUBARA®, a remotely managed training system that we developed, could improve skeletal muscle mass and muscle strength in community-dwelling older adults. SUKUBARA® is a composite exercise program that combines lower-load resistance training and balance exercises. Participants were instructed to exercise while watching individually assigned videos on YouTube, such that the research administrators could verify the viewing records of each participant. Fifteen participants (69 ± 4 years) were randomly assigned to the intervention (eight participants; the RT group) or the control group (seven participants; the CO group). The primary endpoint was a change in fat-free mass (FFM; kg), whereas the secondary endpoints included a change in knee extension strength (KES; Nm/kg). Correlation analyses were conducted to examine the relationship between FFM and KES. During the 12-week intervention period, significant differences were observed between the RT and CO groups in the changes in FFM (0.5 ± 0.5 vs. −0.1 ± 0.5) and KES (0.20 ± 0.22 vs. 0.02 ± 0.13), and significant positive correlations were found between the changes. Thus, SUKUBARA®-based interventions have the potential to improve muscle hypertrophy and enhance muscle strength among community-dwelling older adults. Thus, SUKUBARA® -based interventions show promise in improving muscle hypertrophy and enhance muscle strength among community-dwelling older adults. However, appropriately powered future research is needed to replicate these findings.
Synergistic Effect of Motivation for the Elderly and Support for Going Out II: Measures to Induce Elderly Men to Go Out
Authors: Tsutsui Kenta , Ukita Shoko , Kondo Masahiro , Toshima Genta , Miyazaki Naoki , Nagashima Kengo , Ohmura Mitsuyo , Tsuchihashi Saki , Tsuji Yoshitaka , Katoh Makoto , Aida Naomi , Kobayashi Yoshiki , Ohtsu Yui , Fujita Yoshihiro , Tanaka Shukichi , Watanabe Hiroki , Naruse Yasushi , Iizuka Isao , Kato Hiromi , Mashimo Yumi , Senbonmatsu Takaaki
Published: February 2024

Background: The second demonstration experiment of supporting elderly people going out with the Choisoko system was conducted. The first study showed that for women, friends, shopping, convenience, and events are factors that have the potential to be effective motivational factors for encouraging these women to go out. On the other hand, these factors did not lead to any behavioral change in men. Since there are approximately 15 million men over the age of 65 in Japan, behavioral changes in the entire elderly population will not occur without guidance for elderly men to go out. Methods: Sixteen elderly men and forty-seven elderly women participated. Interestingly, men are far more passionate about games than women. Therefore, we hypothesized that a preference for games could be a hint as to how we might encourage older men to go out. Then, a second demonstration experiment was conducted, and we analyzed the relationship between six game preferences and the frequency of going out. Results: Among gaming preferences, men with gaming preferences such as Philanthropists, Achievers, and Free Spirits showed a tendency to go out. Conclusions: These stimuli may have the potential to be factors that may encourage elderly men to go out.
How to Treat a Cyclist’s Nodule?—Introduction of a Novel, ICG-Assisted Approach
Authors: Mayer Julius M. , Spies Sophie I. , Mayer Carla K. , Zubler Cédric , Loucas Rafael , Holzbach Thomas
Published: February 2024

Background: Perineal nodular induration (PNI) is a benign proliferation of the soft tissue in the perineal region that is associated with saddle sports, especially road cycling. The etiology has not been conclusively clarified; however, repeated microtrauma to the collagen and subcutaneous fat tissue by pressure, vibration and shear forces is considered a mechanical pathomechanism. In this context, chronic lymphedema resulting in the development of fibrous tissue has been suggested as an etiological pathway of PNI. The primary aim of this study was to introduce and elucidate a novel operative technique regarding PNI that is assisted by indocyanine green (ICG). In order to provide some context for this approach, we conducted a comprehensive review of the existing literature. This dual objective aimed to contribute to the existing body of knowledge while introducing an innovative surgical approach for managing PNI. Methods: We reviewed publications relating to PNI published between 1990 and 2023. In addition to the thorough review of the literature, we presented our novel surgical approach. We described how this elaborate approach for extensive cases of PNI involves surgical excision combined with tissue doubling and intraoperative ICG visualization for exact lymphatic vessel obliteration to minimize the risk of recurrence based on the presumed context of lymphatic congestion. Results: The literature research yielded 16 PubMed articles encompassing 23 cases of perineal nodular induration (PNI) or cyclist’s nodule. Of these, 9 cases involved females, and 14 involved males. Conservative treatment was documented in 7 cases (30%), while surgical approaches were reported in 16 cases (70%). Notably, a limited number of articles focused on histopathological or radiological characteristics, with a shortage of structured reviews on surgical treatment options. Only two articles provided detailed insights into surgical techniques. Similarly to the two cases of surgical intervention identified in the literature research, the post-operative recovery in our ICG assisted surgical approach was prompt, meaning a return to cycling was possible six weeks after surgery. At the end of the observation period (twelve months after surgery), regular scar formation and no signs of recurrence were seen. Conclusion: We hope that this article draws attention to the condition of PNI in times of increasing popularity of cycling as a sport. We aimed to contribute to the existing body of knowledge through our thorough review of the existing literature while introducing an innovative surgical approach for managing PNI. Due to the successful outcome, the combination of tissue doubling, intraoperative ICG visualization and postoperative negative wound therapy should be considered as a therapeutic strategy in cases of large PNI.
Polyps’ Extension and Recurrence in Different Endotypes of Chronic Rhinosinusitis: A Series of 449 Consecutive Patients
Authors: Calvanese Leonardo , Fabbris Cristoforo , Brescia Giuseppe , Di Pasquale Fiasca Valerio Maria , Deretti Alessandra , Finozzi Francesco , Franz Leonardo , Frigo Anna Chiara , Marioni Gino
Published: February 2024

Different inflammatory endotypes reflect the heterogeneity of chronic rhinosinusitis with nasal polyps’ (CRSwNPs) clinical presentation. This retrospective study aimed to analyze the distribution of polyps in nasal cavities and paranasal sinuses to establish a possible association between CRSwNP endotypes, prognosis, and polyps’ extension. This study included 449 adult patients who underwent endoscopic sinus surgery for CRSwNPs between 2009 and 2022. Patients were categorized based on the number of paranasal sinuses involved by polyps. Statistical analyses, including Cox regression, were performed to identify associations between demographic, clinical, and histopathological factors and disease recurrence. CRSwNP patients were stratified into four groups based on the extent of polyp involvement. Asthma and acetylsalicylic acid (ASA) sensitivity were associated with more sinuses involved (p-values = 0.0003 and 0.0037, respectively). Blood eosinophil counts increased with the number of sinuses affected (p-value < 0.0001). The distribution of eosinophilic and non-eosinophilic histotypes varied significantly among these groups (p-value < 0.0001). The risk of CRSwNP recurrence was higher in patients with asthma, higher basophil percentages, and eosinophilic histotype (p-value 0.0104, 0.0001, 0.0118, and 0.0104, respectively). This study suggests a positive association between the number of paranasal sinuses involved by polyps and the severity of CRSwNPs, particularly in patients with eosinophilic histotype, asthma, and ASA sensitivity.
Anti-CGRP and Anti-CGRP Receptor Monoclonal Antibodies for Migraine Prophylaxis: Retrospective Observational Study on 209 Patients
Authors: Schweiger Vittorio , Bellamoli Paola , Taus Francesco , Gottin Leonardo , Martini Alvise , Nizzero Marta , Bonora Eleonora , Del Balzo Giovanna , Donadello Katia , Secchettin Erica , Finco Gabriele , Santis Daniele De , Polati Enrico
Published: February 2024

Background: Migraine is a neurological disorder characterized by attacks of head pain with prevalent unilateral localization, moderate to high intensity and specifically associated accompanying symptoms. Methods: In this retrospective observational study, we analyzed data regarding 209 patients who had previously been diagnosed with migraine and who were prescribed, between 2019 and 2022, subcutaneous injections of anti-CGRP monoclonal antibodies (mAbs) fremanezumab or galcanezumab or anti-CGRP receptors mAb erenumab regardless of the concomitant assumption of any other acute-phase or prophylactic migraine medication. Results: Regarding efficacy, in the 205 analyzed patients, the change from baseline in terms of MIDAS, HIT-6, MMDs and MAD scores was statistically significant for erenumab and galcanezumab, while for fremanezumab a statistical significance was not achieved likely due to the small sample size. In the treated population, 36 patients (17.5%) reported AEs (pain during injection, transient injection site erythema, nausea, constipation and fatigue). Only 5 patients (2.4%) discontinued the treatment for AEs while 15 patients (7.3%) left for lack of efficacy. Conclusions: this retrospective study comes out in favor of both significant efficacy and safety of anti-CGRP and anti-CGRP receptors mAbs in migraine patients. Further methodologically stronger studies are necessary to validate our observation.
Development and Internal Validation of a Model for Predicting Overall Survival in Subjects with MAFLD: A Cohort Study
Authors: Bonfiglio Caterina , Campanella Angelo , Donghia Rossella , Bianco Antonella , Franco Isabella , Curci Ritanna , Bagnato Claudia Beatrice , Tatoli Rossella , Giannelli Gianluigi , Cuccaro Francesco
Published: February 2024

Background & Aims: Fatty liver disease with metabolic dysfunction (MAFLD) is a new concept proposed to replace the previous concept of Non-Alcoholic Hepatic Steatosis (NAFLD). We developed and internally validated a prognostic model to predict the likelihood of death in a cohort of subjects with MAFLD. Methods: Our work involved two steps: the first was the construction of a bootstrapped multivariable Cox model for mortality risk prognosis and the second was its validation. Results: The study cohort included 1506 subjects, of which 907 were used for internal validation. Discriminant measures for the final model were R2D 0.6845 and Harrell’s C 0.8422 in the development and R2D 0.6930 and Harrell’s C 0.8465 in the validation. We used the nine independent prognostic factors selected by the LASSO Cox procedure and fitted by the bootstrap Cox survival model, and observed β were: Gender 0.356 1.42 (p < 0.008), Age 0.146 (p < 0.001), Glycemia 0.004 (p < 0.002), Total Cholesterol −0.0040 (p < 0.009), Gamma Glutamyl Transpeptidase 0.009 (p < 0.001), SBP 0.009 (p < 0.036), DBP −0.016 (p < 0.041), ALP 0.008 (p < 0.071) and Widowhood 0.550 (p < 0.001). Conclusions: We produced and validated a model to estimate the probability of death in subjects with MAFLD. The instruments we used showed satisfactory predictive capabilities.
Microbiome Dynamics: A Paradigm Shift in Combatting Infectious Diseases
Authors: Kamel Mohamed , Aleya Sami , Alsubih Majed , Aleya Lotfi
Published: February 2024

Infectious diseases have long posed a significant threat to global health and require constant innovation in treatment approaches. However, recent groundbreaking research has shed light on a previously overlooked player in the pathogenesis of disease—the human microbiome. This review article addresses the intricate relationship between the microbiome and infectious diseases and unravels its role as a crucial mediator of host–pathogen interactions. We explore the remarkable potential of harnessing this dynamic ecosystem to develop innovative treatment strategies that could revolutionize the management of infectious diseases. By exploring the latest advances and emerging trends, this review aims to provide a new perspective on combating infectious diseases by targeting the microbiome.
Non-Pharmacological Intervention for Personalizing Sleep Quality through Gentle Rocking Motion
Authors: Vulturar Damiana-Maria , Moacă Liviu-Ștefan , Chețan Ioana Maria , Vesa Ștefan Cristian , Alexescu Teodora-Gabriela , Grigorescu Cristina , Trofor Antigona Carmen , Stoia Mirela-Anca , Nemes Alexandra Floriana , Todea Doina-Adina
Published: February 2024

Introduction: Achieving restorative sleep is crucial for overall well-being, yet sleep difficulties affect a substantial portion of the adult population. Sleep disturbances are associated with diminished quality of life, physical complaints, cognitive impairment, and emotional regulation challenges. Objective: This study explores the influence of an innovative experimental bed designed to generate rocking motions on sleep parameters. Methods: A prospective observational study enrolled 60 adult participants, assessing their sleep on a regular stationary bed and the Inoveris bed, providing gentle rocking movements. Polysomnography was conducted, recording electroencephalography, electrooculogram, electromyogram, respiratory effort, and other parameters. Results: The rocking bed significantly increased total sleep time (TST) and reduced N1 sleep stage duration (p < 0.001). Participants also experienced a quicker transition to the N2 sleep stage (p = 0.01), indicative of a faster shift from wakefulness to deeper sleep. Additionally, rocking led to a higher percentage of N1 sleep stages (p = 0.01) and a significant increase in N3 sleep stage duration (p = 0.004). While some results lacked statistical significance, notable trends in the rocking bed group have clinical relevance, consistently improving sleep parameters, including increased TST. The rocking bed also showed a trend towards higher sleep efficiency (SE) and sleep duration percentage, hinting at a potential overall enhancement in sleep quality. Conclusion: This study contributes valuable insights into the potential benefits of rocking motions on sleep architecture. Despite variations in outcomes across studies, our results underscore the potential of rocking beds as a non-pharmacological intervention for enhancing sleep quality. Notable improvements in total sleep time (TST), N1 sleep stage reduction, and accelerated transitions to deeper sleep stages highlight the clinical relevance of rocking interventions. Further research, collaboration, and addressing the identified limitations will advance our understanding of the therapeutic applications of rocking motions in sleep science.
UVC Box: An Effective Way to Quickly Decontaminate Healthcare Facilities’ Wheelchairs
Authors: Adam Cloé , Colin Marius , Stock Romuald , Weiss Laurent , Gangloff Sophie C.
Published: February 2024

Disinfection in the hospital environment remains challenging, especially for wide and structurally complex objects such as beds or wheelchairs. Indeed, the regular disinfection of these objects with chemicals is manually carried out by healthcare workers and is fastidious and time-consuming. Alternative antibacterial techniques were thus proposed in the past decades, including the use of naturally antimicrobial UVC. Here, the antibacterial efficiency of a large UVC box built to accommodate wheelchairs was investigated through testing bacterial burden reductions on various parts of a wheelchair, with various support types and with several treatment durations. The results demonstrate a time-dependent antibacterial effect, with a strong burden reduction at only five minutes of treatment (>3-log median reduction in Escherichia coli and Staphylococcus epidermidis). The UVC flux and residual bacterial burden both significantly varied depending on the spatial location on the wheelchair. However, the nature of the support impacted the antibacterial efficiency even more, with residual bacterial burdens being the lowest on rigid materials (steel, plastics) and being the highest on tissue. On metallic samples, the nature of the alloy and surface treatment had various impacts on the antibacterial efficiency of the UVC. This study highlights the efficiency of the tested UVC box to efficiently and quickly decontaminate complex objects such as wheelchairs, but also gives rise to the warning to focus on rigid materials and avoid porous materials in the conception of objects, so as to ensure the efficiency of UVC decontamination.
A Federated Database for Obesity Research: An IMI-SOPHIA Study
Authors: Delfin Carl , Dragan Iulian , Kuznetsov Dmitry , Tajes Juan Fernandez , Smit Femke , Coral Daniel E. , Farzaneh Ali , Haugg André , Hungele Andreas , Niknejad Anne , Hall Christopher , Jacobs Daan , Marek Diana , Fraser Diane P. , Thuillier Dorothee , Ahmadizar Fariba , Mehl Florence , Pattou Francois , Burdet Frederic , Hawkes Gareth , Arts Ilja C. W. , Blanch Jordi , Van Soest Johan , Fernández-Real José-Manuel , Boehl Juergen , Fink Katharina , van Greevenbroek Marleen M. J. , Kavousi Maryam , Minten Michiel , Prinz Nicole , Ipsen Niels , Franks Paul W. , Ramos Rafael , Holl Reinhard W. , Horban Scott , Duarte-Salles Talita , Tran Van Du T. , Raverdy Violeta , Leal Yenny , Lenart Adam , Pearson Ewan , Sparsø Thomas , Giordano Giuseppe N. , Ioannidis Vassilios , Soh Keng , Frayling Timothy M. , Le Roux Carel W. , Ibberson Mark
Published: February 2024

Obesity is considered by many as a lifestyle choice rather than a chronic progressive disease. The Innovative Medicines Initiative (IMI) SOPHIA (Stratification of Obesity Phenotypes to Optimize Future Obesity Therapy) project is part of a momentum shift aiming to provide better tools for the stratification of people with obesity according to disease risk and treatment response. One of the challenges to achieving these goals is that many clinical cohorts are siloed, limiting the potential of combined data for biomarker discovery. In SOPHIA, we have addressed this challenge by setting up a federated database building on open-source DataSHIELD technology. The database currently federates 16 cohorts that are accessible via a central gateway. The database is multi-modal, including research studies, clinical trials, and routine health data, and is accessed using the R statistical programming environment where statistical and machine learning analyses can be performed at a distance without any disclosure of patient-level data. We demonstrate the use of the database by providing a proof-of-concept analysis, performing a federated linear model of BMI and systolic blood pressure, pooling all data from 16 studies virtually without any analyst seeing individual patient-level data. This analysis provided similar point estimates compared to a meta-analysis of the 16 individual studies. Our approach provides a benchmark for reproducible, safe federated analyses across multiple study types provided by multiple stakeholders.
Formation Mechanisms and Crack Propagation Behaviors of White Etching Layers and Brown Etching Layers on Raceways of Failure Bearings
Authors: Zhang Xiaochen , Wu Di , Zhang Yaming , Xu Lijia , Wang Jianqiu , Han En-Hou
Published: February 2024

White etching layers (WELs) and brown etching layers (BELs), formed on the upper layer of bearing raceways generally lead to surface crack initiation and propagation and significantly affect the stable operation of precision bearings. In this study, the microstructure features of WELs and BELs from two failure bearings have been characterized and analyzed. The BEL mainly consists of quenched martensite with higher hardness values. The bainite simultaneously exists at the boundary of the BEL/matrix. Owing to the relative roll and slip, temperature increases and rapid decreases are the main formation mechanisms of the BEL in this study (thermal-induced effect). The WEL can be only found on one sample, and elongated and coarse grains are found in this region. It can be speculated that the WEL may originate from the surface region temperature increasing again and then slowly decreasing. Cracks can initiate at the boundaries of the WEL/BEL/matrix. The crack propagation behaviors are significantly affected by the properties of the WEL and BEL microstructure. It is difficult for the cracks to propagate from a softer WEL into a harder BEL. Thus, the depth of cracks in the WEL is shallower. However, because of the brittle nature of quenched martensite in the BEL, cracks can easily propagate downward under contact stress. Thus, the depth of cracks can exceed 100 μm easily. The formation mechanisms of the WEL/BEL and crack propagation behaviors have been further proved and discussed in this study.
Complex Connections between Symmetry and Singularity Analysis
Authors: Qadir Asghar
Published: February 2024

In this paper, it is noted that three apparently disparate areas of mathematics—singularity analysis, complex symmetry analysis and the distributional representation of special functions—have a basic commonality in the underlying methods used. The insights obtained from the first of these provides a much-needed explanation for the effectiveness of the latter two. The consequent explanations are provided in the form of two theorems and their corollaries.
Endoscopic Management of Difficult Biliary Stones: An Evergreen Issue
Authors: Manti Magdalini , Shah Jimil , Papaefthymiou Apostolis , Facciorusso Antonio , Ramai Daryl , Tziatzios Georgios , Papadopoulos Vasilios , Paraskeva Konstantina , Papanikolaou Ioannis S. , Triantafyllou Konstantinos , Arvanitakis Marianna , Archibugi Livia , Vanella Giuseppe , Hollenbach Marcus , Gkolfakis Paraskevas
Published: February 2024

Choledocholithiasis is one of the most common indications for endoscopic retrograde cholangiopancreatography (ERCP) in daily practice. Although the majority of stones are small and can be easily removed in a single endoscopy session, approximately 10–15% of patients have complex biliary stones, requiring additional procedures for an optimum clinical outcome. A plethora of endoscopic methods is available for the removal of difficult biliary stones, including papillary large balloon dilation, mechanical lithotripsy, and electrohydraulic and laser lithotripsy. In-depth knowledge of these techniques and the emerging literature on them is required to yield the most optimal therapeutic effects. This narrative review aims to describe the definition of difficult bile duct stones based on certain characteristics and streamline their endoscopic retrieval using various modalities to achieve higher clearance rates.
The Efficacy of Lactobacillus delbrueckii ssp. bulgaricus Supplementation in Managing Body Weight and Blood Lipids of People with Overweight: A Randomized Pilot Trial
Authors: Chu Pei-Yi , Yu Ying-Chun , Pan Yi-Cheng , Dai Yun-Hao , Yang Juan-Cheng , Huang Kuo-Chin , Wu Yang-Chang
Published: February 2024

This study aimed to evaluate the efficacy of Lactobacillus delbrueckii ssp. bulgaricus (L. bulgaricus) in improving body weight, obesity-related outcomes, and lipid profiles of overweight people. Thirty-six overweight participants were randomly assigned to either a probiotic or a placebo group. A placebo powder or L. bulgaricus powder (containing 1 × 108 colony-forming unit (CFU) of the probiotic) was administered daily for 12 weeks. Body composition was determined, and blood tests were performed before and after the intervention. L. bulgaricus supplementation under the present condition did not affect the body weight, fat percentage, or body mass index (BMI) of the participants, while it resulted in a notable decrease in blood triglyceride (TG) levels, which corresponded to a lowering of the TG proportion in the composition of large VLDL (L–XXL sized fractions) and HDL (M and L fractions) in the probiotic-treated group. These results suggest that L. bulgaricus supplementation under the current conditions may not be helpful for losing weight, but it has the potential to decrease blood TG levels by modulating TG accumulation in or transport by VLDL/HDL in obese patients. L. bulgaricus supplements may have health-promoting properties in preventing TG-related diseases in overweight people.
Association of Dietary Protein Sources and Their Adequacy, Body Composition and Risk of Sarcopenic Obesity in South Korean Populations: A Cross-Sectional Study
Authors: Kim Jieun , Jeong Kyoungsik , Lim Sueun , Lee Siwoo , Baek Younghwa
Published: February 2024

Dietary protein sources and protein adequacy are crucial modulators of muscle quality and body composition. We investigated the association between dietary protein sources (and their adequacy) and body composition and the risk of sarcopenic obesity (SO) in South Korean populations. The participants (n = 1967) were classified into SO, obese, sarcopenia, and normal groups. A cross-sectional survey was conducted using the KS-15 questionnaire, short-form food frequency questionnaire, and anthropometric measurements. The percentage of body fat (male: 35.36 ± 0.51%; female: 44.14 ± 0.36%) was significantly high, while appendicular skeletal muscle (ASM; male: 36.39 ± 0.30%, female: 30.32 ± 0.19%) was low in the SO group. Beef and pork consumption was negatively associated with ASM (%) but positively associated with body fat (%) in the normal group and positively associated with ASM (kg/m2: beta = 0.002, p = 0.02) and BFM (kg: beta = 0.012, p = 0.03) in the SO group, respectively. The highest quintile (Q5: 173.6 g/day) showed a decreased risk of SO prevalence (AORs: 0.46, CI: 0.22–0.94) compared with that in the lowest quintile (Q1: 21.6 g/day) among the people with inadequacy protein intake. Daily poultry and egg intake was positively linked with body composition in the participants with SO, while red meat showed a negative effect on imbalanced body composition in participants in the normal and SO groups. Furthermore, a lower intake of poultry and eggs was strongly associated with SO prevalence in people who consumed inadequate amounts of daily dietary protein.
In Silico Identification of Sugarcane Genome-Encoded MicroRNAs Targeting Sugarcane Mosaic Virus
Authors: Wenzhi Wang , Ashraf Muhammad Aleem , Ghaffar Hira , Ijaz Zainab , Zaman Waqar ul , Mazhar Huda , Zulfqar Maryam , Zhang Shuzhen
Published: February 2024

Sugarcane mosaic virus (SCMV) (genus, Potyvirus; family, Potyviridae) is widespread, deleterious, and the most damaging pathogen of sugarcane (Saccharum officinarum L. and Saccharum spp.) that causes a substantial barrier to producing high sugarcane earnings. Sugarcane mosaic disease (SCMD) is caused by a single or compound infection of SCMV disseminated by several aphid vectors in a non-persistent manner. SCMV has flexuous filamentous particle of 700–750 nm long, which encapsidated in a positive-sense, single-stranded RNA molecule of 9575 nucleotides. RNA interference (RNAi)-mediated antiviral innate immunity is an evolutionarily conserved key biological process in eukaryotes and has evolved as an antiviral defense system to interfere with viral genomes for controlling infections in plants. The current study aims to analyze sugarcane (Saccharum officinarum L. and Saccharum spp.) locus-derived microRNAs (sof-miRNAs/ssp-miRNAs) with predicted potential for targeting the SCMV +ssRNA-encoded mRNAs, using a predictive approach that involves five algorithms. The ultimate goal of this research is to mobilize the in silico- predicted endogenous sof-miRNAs/ssp-miRNAs to experimentally trigger the catalytic RNAi pathway and generate sugarcane cultivars to evaluate the potential antiviral resistance surveillance ability and capacity for SCMV. Experimentally validated mature sugarcane (S. officinarum, 2n = 8X = 80) and (S. spp., 2n = 100–120) sof-miRNA/ssp-miRNA sequences (n = 28) were downloaded from the miRBase database and aligned with the SCMV genome (KY548506). Among the 28 targeted mature locus-derived sof-miRNAs/ssp-miRNAs evaluated, one sugarcane miRNA homolog, sof-miR159c, was identified to have a predicted miRNA binding site, at nucleotide position 3847 of the SCMV genome targeting CI ORF. To verify the accuracy of the target prediction accuracy and to determine whether the sugarcane sof-miRNA/ssp-miRNA could bind the predicted SCMV mRNA target(s), we constructed an integrated Circos plot. A genome-wide in silico-predicted miRNA-mediated target gene regulatory network was implicated to validate interactions necessary to warrant in vivo analysis. The current work provides valuable computational evidence for the generation of SCMV-resistant sugarcane cultivars.
Tailings Behavior Assessment Using Piezocone Penetration Test
Authors: Wróżyńska Magdalena
Published: February 2024

Intensive economic development is associated with an increasing demand for raw materials, including minerals. An illustrative example of this issue is the development of the copper industry. A significant problem arising from the scale of copper production is the management of an ever-growing amount of post-flotation tailings. This necessitates the need to ensure the continuity of safe storage. This study presents the results of studies on the behavior of deposits in the Żelazny Most Tailings Storage Facility (Poland). The primary objective of this study was to estimate the settlements of tailings under variable deposition conditions. The results were assessed using two methods: indirect and direct; this was based on cone penetration test (CPTU) results. The results were verified using Modified Cam Clay (MCC) modeling. Depending on the type of test, settlements ranged from several dozen centimeters to over three meters. Despite the observed differences, the results of both CPTU methods indicate a convergent trend in tailings behavior. Conversely, the results estimated using the direct method and numerical modeling demonstrate a high level of agreement.
Elemental Fingerprinting of Pecorino Romano and Pecorino Sardo PDO: Characterization, Authentication and Nutritional Value
Authors: Mara Andrea , Caredda Marco , Addis Margherita , Sanna Francesco , Deroma Mario , Georgiou Constantinos A. , Langasco Ilaria , Pilo Maria I. , Spano Nadia , Sanna Gavino
Published: February 2024

Sardinia, located in Italy, is a significant producer of Protected Designation of Origin (PDO) sheep cheeses. In response to the growing demand for high-quality, safe, and traceable food products, the elemental fingerprints of Pecorino Romano PDO and Pecorino Sardo PDO were determined on 200 samples of cheese using validated, inductively coupled plasma methods. The aim of this study was to collect data for food authentication studies, evaluate nutritional and safety aspects, and verify the influence of cheesemaking technology and seasonality on elemental fingerprints. According to European regulations, one 100 g serving of both cheeses provides over 30% of the recommended dietary allowance for calcium, sodium, zinc, selenium, and phosphorus, and over 15% of the recommended dietary intake for copper and magnesium. Toxic elements, such as Cd, As, Hg, and Pb, were frequently not quantified or measured at concentrations of toxicological interest. Linear discriminant analysis was used to discriminate between the two types of pecorino cheese with an accuracy of over 95%. The cheese-making process affects the elemental fingerprint, which can be used for authentication purposes. Seasonal variations in several elements have been observed and discussed.
Electrolyte Optimization Strategy: Enabling Stable and Eco-Friendly Zinc Adaptive Interfacial Layer in Zinc Ion Batteries
Authors: Cao Bozhong , Xu Chunyan , Jiang Bingchun , Jin Biao , Zhang Jincheng , Ling Lei , Lu Yusheng , Zou Tianyu , Zhang Tong
Published: February 2024

Aqueous zinc ion batteries (AZIBs) have emerged as a promising battery technology due to their excellent safety, high capacity, low cost, and eco-friendliness. However, the cycle life of AZIBs is limited by severe side reactions and zinc dendrite growth on the zinc electrode surface, hindering large-scale application. Here, an electrolyte optimization strategy utilizing the simplest dipeptide glycylglycine (Gly-Gly) additive is first proposed. Theoretical calculations and spectral analysis revealed that, due to the strong interaction between the amino group and Zn atoms, Gly-Gly preferentially adsorbs on zinc’s surface, constructing a stable and adaptive interfacial layer that inhibits zinc side reactions and dendrite growth. Furthermore, Gly-Gly can regulate zinc ion solvation, leading to a deposition mode shift from dendritic to lamellar and limiting two-dimensional dendrite diffusion. The symmetric cell with the addition of a 20 g/L Gly-Gly additive exhibits a cycle life of up to 1100 h. Under a high current density of 10 mA cm−2, a cycle life of 750 cycles further demonstrates the reliable adaptability of the interfacial layer. This work highlights the potential of Gly-Gly as a promising solution for improving the performance of AZIBs.
Stiffness Modulation in Flexible Rotational Triboelectric Nanogenerators for Dual Enhancement of Power and Reliability
Authors: Li Feng , Yin Ao , Zhou Yaao , Liu Tao , Liu Qingqing , Ruan Weijie , Bu Ling
Published: February 2024

Rotational nanogenerators with flexible triboelectric layers have wide applications and high reliability. However, flexible materials cause a severe reduction in contact force and thus triboelectric output power. Unlike previous works devising complex auxiliary structures to solve this issue, this paper focuses on improving the contact material mechanics and proposes a stiffness modulation method. By introducing fine patterns to the contacting rotor–stator pairs, the effective elastic modulus was regulated from approximately 103 to 105 MPa, and the output voltage was modulated from approximately 24.39% to 375.87% compared to the non-patterned rotor–stator pairs, corresponding to a maximal a 14 times increase in output power. A maximal power density of 18.75 W/m2 was achieved on 10 MΩ resistance at 9.6 Hz, which is even beyond the power density of most rigid triboelectric interfaces. Moreover, high reliability could be maintained when the volume ratio of the horizontal patterns exceeded a threshold value of 33.5% as the stator and 63.6% as the rotor for a 0.5 mm linewidth. These results prove the efficacy of the stiffness modulation method for jointly achieving high output power and high reliability in flexible rotational triboelectric nanogenerators.
Enhancement of Carrier Mobility in Multilayer InSe Transistors by van der Waals Integration
Authors: Li Zhiwei , Liu Jidong , Ou Haohui , Hu Yutao , Zhu Jiaqi , Huang Jiarui , Liu Haolin , Tu Yudi , Qi Dianyu , Hao Qiaoyan , Zhang Wenjing
Published: February 2024

Two-dimensional material indium selenide (InSe) holds great promise for applications in electronics and optoelectronics by virtue of its fascinating properties. However, most multilayer InSe-based transistors suffer from extrinsic scattering effects from interface disorders and the environment, which cause carrier mobility and density fluctuations and hinder their practical application. In this work, we employ the non-destructive method of van der Waals (vdW) integration to improve the electron mobility of back-gated multilayer InSe FETs. After introducing the hexagonal boron nitride (h-BN) as both an encapsulation layer and back-gate dielectric with the vdW interface, as well as graphene serving as a buffer contact layer, the electron mobilities of InSe FETs are substantially enhanced. The vdW-integrated devices exhibit a high electron mobility exceeding 103 cm2 V−1 s−1 and current on/off ratios of ~108 at room temperature. Meanwhile, the electron densities are found to exceed 1012 cm−2. In addition, the fabricated devices show an excellent stability with a negligible electrical degradation after storage in ambient conditions for one month. Electrical transport measurements on InSe FETs in different configurations suggest that a performance enhancement with vdW integration should arise from a sufficient screening effect on the interface impurities and an effective passivation of the air-sensitive surface.
Cement/Sulfur for Lithium–Sulfur Cells
Authors: Hung Tzu-Ming , Wu Cheng-Che , Hung Chung-Chan , Chung Sheng-Heng
Published: February 2024

Lithium–sulfur batteries represent a promising class of next-generation rechargeable energy storage technologies, primarily because of their high-capacity sulfur cathode, reversible battery chemistry, low toxicity, and cost-effectiveness. However, they lack a tailored cell material and configuration for enhancing their high electrochemical utilization and stability. This study introduces a cross-disciplinary concept involving cost-efficient cement and sulfur to prepare a cement/sulfur energy storage material. Although cement has low conductivity and porosity, our findings demonstrate that its robust polysulfide adsorption capability is beneficial in the design of a cathode composite. The cathode composite attains enhanced cell fabrication parameters, featuring a high sulfur content and loading of 80 wt% and 6.4 mg cm−2, respectively. The resulting cell with the cement/sulfur cathode composite exhibits high active-material retention and utilization, resulting in a high charge storage capacity of 1189 mA∙h g−1, high rate performance across C/20 to C/3 rates, and an extended lifespan of 200 cycles. These attributes contribute to excellent cell performance values, demonstrating areal capacities ranging from 4.59 to 7.61 mA∙h cm−2, an energy density spanning 9.63 to 15.98 mW∙h cm−2, and gravimetric capacities between 573 and 951 mA∙h g−1 per electrode. Therefore, this study pioneers a new approach in lithium–sulfur battery research, opting for a nonporous material with robust polysulfide adsorption capabilities, namely cement. It effectively showcases the potential of the resulting cement/sulfur cathode composite to enhance fabrication feasibility, cell fabrication parameters, and cell performance values.
Contacts at the Nanoscale and for Nanomaterials
Authors: Wong Hei , Zhang Jieqiong , Liu Jun
Published: February 2024

Contact scaling is a major challenge in nano complementary metal–oxide–semiconductor (CMOS) technology, as the surface roughness, contact size, film thicknesses, and undoped substrate become more problematic as the technology shrinks to the nanometer range. These factors increase the contact resistance and the nonlinearity of the current–voltage characteristics, which could limit the benefits of the further downsizing of CMOS devices. This review discusses issues related to the contact size reduction of nano CMOS technology and the validity of the Schottky junction model at the nanoscale. The difficulties, such as the limited doping level and choices of metal for band alignment, Fermi-level pinning, and van der Waals gap, in achieving transparent ohmic contacts with emerging two-dimensional materials are also examined. Finally, various methods for improving ohmic contacts’ characteristics, such as two-dimensional/metal van der Waals contacts and hybrid contacts, junction doping technology, phase and bandgap modification effects, buffer layers, are highlighted.