bluuebunny/crossref_metadata_2025 huggingface dataset:
Précis on Knowing and Checking: an Epistemological Investigation
Authors: Melchior Guido
Published: December 2022

In this Précis, I provide an overview of my Monograph Knowing and Checking: An Epistemological Investigation (Melchior 2019), which is subject to a book symposium organized by the University of Maribor. This volume in Acta Analytica contains contributions by Peter Baumann, Kelly Becker, Marian David, Nenad Miščević, Robert Weston Siscoe, and Danilo Šuster along with my replies.
Cluster-based characterization of consistencies in individuals' thought profiles at rest in a cohort of 1779 French university students
Authors: Cremona Sandrine , Joliot Marc , Mellet Emmanuel
Published: December 2022

Is ongoing conscious thought spontaneous and situation-related, or is it recurrent and dependent on psychological dispositions? The answer is critical for resting-state functional connectivity (RSFC) paradigms that seek to correlate neuroanatomical states with conscious mental states. The goal of the present study was to characterize individual resting state thought profiles (RSTPs) and identify the recurrent ones, i.e., that could both be predicted by personality traits and predict subsequent negative affective states. The 1779 participants had a mean age of 22.1 years, 71.8% were females, and 71.8% were undergraduates. We collected the form and content of their thoughts during a 15-min RSFC session with a computerized retrospective self-questionnaire (ReSQ 2.0). Subsamples of participants also completed online autoquestionnaires assessing their psychological maturity and trait negative affectivity (with a four-day gap on average, N = 1270) and subsequent depressive and anxious states (1.4 years later on average, N = 922). Based on the multiple correspondence and clustering analyses of the ReSQ 2.0 responses, we identified six RSTPs distinctive by their content scope, temporal orientation, empathetic concern, and emotional valence. Multivariate analyses revealed that the probability of experiencing five of the six RSTPs was predicted by trait negative affectivity interacting with psychological maturity. Among them, a negatively valenced RSTP also increased the likelihood of subsequent negative affective states, suggesting its stable and recurrent nature. Identifying recurrent RSTPs is helpful for the future understanding of RSTPs’ contribution to RSFC. Additionally, it will be relevant to test whether acting on psychological maturity can alter the relationship between ongoing conscious thought and negative affectivity.
People or Ideology? Social Conservatism and Intergroup Contact Moderate Heterosexuals’ Responses to a State-sponsored Anti-LGBT Campaign
Authors: Górska Paulina , Tausch Nicole
Published: December 2022

Introduction

Recent years have witnessed the global rise of illiberal regimes, which built widespread support by initiating hate campaigns against minorities. This research examined a government-led anti-LGBT campaign in Poland and its impact upon attitudes of the wider public.

Methods

Our study (N = 2061 heterosexual participants) assessed sexual prejudice (blatant dehumanization and modern homonegativity) and pro- and anti-minority action intentions in two representative surveys, conducted before (fall 2018; N = 821) and after (summer 2019; N = 1240) the beginning of the anti-LGBT campaign.

Results

Prejudice and anti-minority action tendencies increased during the analyzed period. However, there was also an increase in pro-minority action tendencies, demonstrating public resistance. These effects were moderated by respondents’ levels of social conservatism and their prior contact with LGBT people. Low (compared to high) levels of social conservatism reduced (or even reversed) the impact of the state-sponsored anti-LGBT campaign on sexual prejudice, which further translated into pro- and anti-minority collective action intentions. High (compared to low) levels of contact predicted a reduced effect of the campaign on blatant dehumanization, which translated into lower anti-minority action tendencies. Blatant dehumanization and modern homonegativity differentially predicted participants’ willingness to engage in pro- and anti-minority collective action, highlighting the importance of taking a more granular approach when predicting action intentions.

Policy Implications

We discuss implications for interventions aimed at protecting vulnerable groups in the face of anti-minority rhetoric.
Engaging Epistemically with the Other: Toward a More Dialogical and Plural Understanding of the Remedy for Testimonial Injustice
Authors: Carmona Carla
Published: December 2022

The concept of testimonial injustice (TI) has been expanded considerably since Fricker's groundbreaking original formulation. Testimonial void (TV), as well as other kinds of TI identified in the last decade, encourage the idea that the virtue of testimonial justice (TJ) is not the appropriate remedy to battle against injustice in our testimonial exchanges. This paper contributes to the existing literature on the limitations of TJ as the remedy for TI by drawing attention to its shortcomings in the context of other kinds of TI. By contrast, I propose further engaging epistemically with the other (EE) as a corrective to injustice in our testimonial exchanges. I understand EE as a practice in which information regarding epistemic injustice, strategies to fight it and skills training play the leading roles. If the problem lies in lack of appropriate epistemic interaction between knowers, we need to train ourselves to do what we fail to do. Given that we are in the domain of testimony, EE essentially amounts to engaging further with the other in conversation. In the process, EE sheds light on the need for second-order change to fight TI, as enacting EE would require the transformation of our concepts of testimony and credibility.
Concept Revision, Concept Application and the Role of Intuitions in Gettier Cases
Authors: Sękowski Krzysztof
Published: December 2022

The aim of the paper is to determine the role of intuitions in Gettier cases. Critics of the Method of Cases argue that arguments developed within this method contain a premise that is justified by its intuitiveness; they also argue that intuitions are unreliable sources of evidence. By contrast, Max Deutsch argues that this critique is unsound since intuitions do not serve as evidence for premises. In Gettier cases, an intuitive premise is justified by other arguments called G-Grounds. I propose a different view on the role of intuition in Gettier cases. I introduce a distinction between concept-revision arguments and concept-application arguments. On the basis of this distinction and Craig's and Spicer's distinction between intuitions of intension and intuitions of extension, I show that (1) intuitions of extension do not serve as evidence for any G-Grounds; (2) intuitions of intension do play an evidential role for all G-Grounds, but (3) in the case of G-Grounds which are used as concept-application arguments, they are a poor source of evidence, while (4) in the case of G-Grounds used as concept-revision arguments, they could be a reliable source of evidence if they are intuitions of intension of a speaker immersed in philosophical discourse.
Smartphone-delivered mental health care interventions for refugees: A systematic review of the literature
Authors: El-Haj-Mohamad Rayan , Nohr Laura , Niemeyer Helen , Böttche Maria , Knaevelsrud Christine
Published: December 2022

According to the United Nations, an estimated 26.6 million people worldwide were refugees in 2021. Experiences before, during, and after flight increase psychological distress and contribute to a high prevalence of mental disorders. The resulting high need for mental health care is generally not reflected in the actual mental health care provision for refugees. A possible strategy to close this gap might be to offer smartphone-delivered mental health care. This systematic review summarizes the current state of research on smartphone-delivered interventions for refugees, answering the following research questions: (1) Which smartphone-delivered interventions are available for refugees? (2) What do we know about their clinical (efficacy) and (3) nonclinical outcomes (e.g., feasibility, appropriateness, acceptance, and barriers)? (4) What are their dropout rates and dropout reasons? (5) To what extent do smartphone-delivered interventions consider data security? Relevant databases were systematically searched for published studies, gray literature, and unpublished information. In total, 456 data points were screened. Twelve interventions were included (nine interventions from 11 peer-reviewed articles and three interventions without published study reports), comprising nine interventions for adult refugees and three for adolescent and young refugees. Study participants were mostly satisfied with the interventions, indicating adequate acceptability. Only one randomized controlled trial (RCT; from two RCTs and two pilot RCTs) found a significant reduction in the primary clinical outcome compared to the control group. Dropout rates ranged from 2.9 to 80%. In the discussion, the heterogeneous findings are integrated into the current state of literature.
Impact of temporal modulations on laser-induced damage of fused silica at 351 nm
Authors: Bouyer C. , Parreault R. , Roquin N. , Natoli J.-Y. , Lamaignère L.
Published: December 2022

Laser-induced damage (LID) on high-power laser facilities is one of the limiting factors for the increase in power and energy. Inertial confinement fusion (ICF) facilities such as Laser Mégajoule or the National Ignition Facility use spectral broadening of the laser pulse that may induce power modulations because of frequency modulation to amplitude modulation conversion. In this paper, we study the impact of low and fast power modulations of laser pulses both experimentally and numerically. The MELBA experimental testbed was used to shape a wide variety of laser pulses and to study their impact on LID. A 1D Lagrangian hydrodynamic code was used to understand the impact of different power profiles on LID.
Symmetry-reduced dynamic mode decomposition of near-wall turbulence
Authors: Marensi E. , Yalnız G. , Hof B. , Budanur N.B.
Published: December 2022

Data-driven dimensionality reduction methods such as proper orthogonal decomposition and dynamic mode decomposition have proven to be useful for exploring complex phenomena within fluid dynamics and beyond. A well-known challenge for these techniques is posed by the continuous symmetries, e.g. translations and rotations, of the system under consideration, as drifts in the data dominate the modal expansions without providing an insight into the dynamics of the problem. In the present study, we address this issue for fluid flows in rectangular channels by formulating a continuous symmetry reduction method that eliminates the translations in the streamwise and spanwise directions simultaneously. We demonstrate our method by computing the symmetry-reduced dynamic mode decomposition (SRDMD) of sliding windows of data obtained from the transitional plane-Couette and turbulent plane-Poiseuille flow simulations. In the former setting, SRDMD captures the dynamics in the vicinity of the invariant solutions with translation symmetries, i.e. travelling waves and relative periodic orbits, whereas in the latter, our calculations reveal episodes of turbulent time evolution that can be approximated by a low-dimensional linear expansion.
Water wave cloaking using a floating composite plate
Authors: Iida Takahito , Zareei Ahmad , Alam Mohammad-Reza
Published: December 2022

The trajectory of surface gravity waves in the potential flow regime is affected by the gravitational acceleration, water density and sea bed depth. Although the gravitational acceleration and water density are approximately constant, the effect of water depth on surface gravity waves exponentially decreases as the water depth increases. In shallow water, cloaking an object from surface waves by varying the sea bed topography is possible, however, as the water depth increases, cloaking becomes a challenge because there is no physical parameter to be engineered and subsequently affects the wave propagation. In order to create an omnidirectional cylindrical cloaking device for finite-depth/deep-water waves, we propose an elastic composite plate that floats on the surface around a to-be-cloaked cylinder. The composite plate is made of axisymmetric, homogeneous and isotropic annular thin rings which provide adjustable degrees of freedom to engineer and affect the wave propagation. We first develop a pseudo-spectral method to efficiently determine the wave solution for a floating composite plate. Next, we optimise the physical parameters of the plate (i.e. flexural rigidity and mass of every ring) using an evolutionary algorithm to minimise the energy of scattered waves from the object and therefore cloak the inner cylinder from incident waves. We show that the optimised cloak reduces the energy of scattered waves as high as 99 % for the target wave number. We quantify the effectiveness of our cloak with different parameters of the plate and show that varying the flexural rigidity is essential to control wave propagation and the cloaking structure needs to be at least made of four rings with a radius of at least three times of the cloaked region. We quantify the wave drift force exerted on the structures and show that the optimised plate reduces the exerted force by 99.9 %. The proposed cloak, due to its structural simplicity and effectiveness in reducing the wave drift force, may have potential applications in cloaking offshore structures from water waves.
Inmate Litigation, Legal Access, and Prison Privatization
Authors: Gunderson Anna
Published: December 2022

Debates over prison privatization neglect to consider differences in legal access across private and public prisons. I argue that private prisons experience lower filing rates than public prisons, and that cases brought against publicly traded private prison companies are less likely to be dismissed and more likely to succeed than similar cases against public prisons. I find evidence consistent with these claims, a result that is not driven by other explanations of judicial decision-making. This paper has implications for skepticism of private interests in public policymaking, and encourages investigation of access to justice for inmates in public and private custody.
INFLUENCE OF AIR PARCELS FROM NORTHERN AND SOUTHERN HEMISPHERES ON RADIOCARBON-BASED INCA CHRONOLOGY
Authors: Ancapichún Santiago , Pawlyta Jacek , Rakowski Andrzej Z , Sieczkowska Dominika
Published: December 2022

The chronology of Machu Picchu was traditionally associated with the period attributed to the reign of Pachacuti Inca Yupanqui. Within the scheme of the so-called “historical chronology”, proposed by John H. Rowe in 1945, the ascension to power of Pachacuti Inca took place around 1438 CE, and the construction of Machu Picchu began by 1450–1460 CE. Several radiocarbon-dated samples may help to understand the chronology of the construction of llaqta of Machu Picchu, Chachabamba, and Choqesuysuy. However, there is a lack of consensus between different radiocarbon-based Inca chronologies because of the lack of information of which calibration curves to use: Northern Hemisphere (NH), Southern Hemisphere (SH), or a mixed calibration curve? Thus, the main goal of the present investigation is to develop a new methodological approach to reconstruct a radiocarbon-based Incan chronology, an approach based on the determination, through modeling, of the proportion of NH and SH air parcels arriving at three relevant Inca settlements. We found air parcel contributions from the NH and SH for Machu Picchu (51% NH and 49% SH), Chamical (29% NH and 71% SH), and Tiquischullpa (41% NH and 59% SH). Thereby, our investigation brings three proportions to mix NH and SH14C curves, based on an empirical method and supported by a high-resolution paleoclimatic tracer, for Inca radiocarbon dating studies. Our study emphasizes that great attention should be paid when applying radiocarbon calibration to radiocarbon measurements of samples originating from regions under the influence of the atmospheric circulation-boundary between hemispheres.
A NOTE: RADIOCARBON DATA COMPARISON OF SMALL GASEOUS SAMPLES MEASURED BY TWO MICADAS AT ETH ZURICH AND OCEAN UNIVERSITY OF CHINA
Authors: Chu M , Bao R
Published: December 2022

A MIni CArbon DAting System (MICADAS) has been recently installed at the Ocean University of China (OUC) mainly for determining the radiocarbon (14C) ages for marine sedimentary organic carbon. In this study, we compared the data from a series of CO2 samples measured independently by the MICADAS at OUC and ETH Zurich to assess whether the data from the OUC MICADAS meet our requirement for carbon cycle research. The measured samples covered a range of 14C ages from 1229 to 12,287 yr, and size from 5 to 162 µg C. The data from the two instruments showed a good linear relationship with only small 14C age offsets, meeting our research demands such as carbon source apportionment. Lastly, we propose that for MICADAS clients, such a cross-lab comparison of the size- and age-dependency of MICADAS using age-known samples is important for 14C data integration.
Who Deserves European Solidarity? How Recipient Characteristics Shaped Public Support for International Medical and Financial Aid during COVID-19
Authors: Heermann Max , Koos Sebastian , Leuffen Dirk
Published: December 2022

International solidarity is indispensable for coping with global crises; however, solidarity is frequently constrained by public opinion. Past research has examined who, on the donor side, is willing to support European and international aid. However, we know less about who, on the recipient side, is perceived to deserve solidarity. The article argues that potential donors consider situational circumstances and those relational features that link them to the recipients. Using factorial survey experiments, we analyse public support for international medical and financial aid in Germany during the COVID-19 pandemic. Our results show that recipient countries' situational need and control, as well as political community criteria, namely, group membership, adherence to shared values and reciprocity, played a crucial role in explaining public support for aid. Important policy implications result: on the donor side, fault-attribution frames matter; on the recipient side, honouring community norms is key to receiving aid.
The intricate inflectional relationships underpinning morphological analogy
Authors: ESHER LOUISE
Published: December 2022

In Gévaudan varieties of Occitan (Gallo-Romance), exceptionless syncretism between preterite and imperfect subjunctive forms arises in the first and second person plural (e.g. faguessiám [faɡeˈsjɔn] ‘do.pret/ipf.sbjv.1pl’, faguessiatz [faɡeˈsjat] ‘do.pret/ipf.sbjv.2pl’). Reconstructing the historical emergence of this syncretism pattern reveals that it is crucially dependent on multiple and diverse implicational relationships of form, inferred and productively exploited by speakers: in particular, inherited identity between preterite and imperfect subjunctive stems, and identity between imperfect indicative forms of èstre [ɛsˈtʀe] ‘be’ and preterite or imperfect subjunctive desinences. The observed developments support a view of inflectional analogies as informed by intricate paradigmatic and implicational structure of the type proposed within ‘abstractive’, word-based theories of inflection.
PP70 Enhancing HTA Processes In The Maltese System For Introducing New Medicines
Authors: de Vries Simone , Abraham Katharina , Sammut Sylvana Magrin , Formosa Antonia , Ramos Isaac Corro , Verteegh Matthijs , Dupree Rudy , van der Waal Annemieke , Franken Margreet , Goettsch Wim
Published: December 2022

Introduction

Most European countries use Health Technology Assessment (HTA) as input for decisions on reimbursement of (new) medicines. In 2018, following the approval of European Social Funding, the Directorate for Pharmaceutical Affairs (DPA) within the Malta Ministry for Health led a specific Work Package aimed at enhancing knowledge, skills and HTA processes to inform reimbursement decisions.

Methods

Since the start of the project, the Institute for Medical Technology Assessment (iMTA) and the National Health Care Institute of the Netherlands (ZIN) collaborate in providing guidance and training to DPA on relative effectiveness assessments (REAs) and pharmacoeconomic assessments (PEAs) of pharmaceuticals. Several activities were organized: site visits, face-to face interviews with stakeholders, a qualitative assessment of the core process of the Maltese system, health economics training and tutorials, meetings introducing the European Network for Health Technology Assessment (EUnetHTA) and Dutch HTA processes, development of a new framework for assessment, and a shadow assessment.

Results

Our assessment identified important methodological challenges and crucial processes interdependencies to optimize within the Maltese system. Based on the learnings, DPA created a template based on the EUnetHTA REA assessment format. IMTA created a template to perform PEAs. Currently, a shadow assessment is ongoing in which DPA performs the REA and PEA of a pharmaceutical using the new templates. ZIN and iMTA will provide feedback to DPA on several aspects, including, but not limited to, the PICO, assessment of therapeutic efficacy and safety, identifying uncertainties, input costs and effects, and formulating a clear discussion of the assessment. If necessary, the templates will be adapted during the process. The project will be evaluated and finalized in 2022.

Conclusions

With the guidance and training provided by iMTA and ZIN, DPA structured and aligned their REA and PEA to enhance their assessment process and to improve the presentation of their HTA report to the two appraisal committees. This project emphasizes the importance of international collaboration to enhance HTA processes within the
Perceptual integrality of foreign segmental and tonal information: Dimensional transfer hypothesis
Authors: Choi William , Tsui Rachel Ka-Ying
Published: December 2022

This study investigates whether (a) Cantonese and (b) English listeners integrally or independently perceive Thai tone and segmental information. Listeners completed a modified AX discrimination task that contained a control block (without segmental variation) and an orthogonal block (with segmental variation). Relative to their own performance in the control block, the Cantonese listeners showed increased response time, decreased proportion of accuracy, and decreased sensitivity index in the orthogonal block. By contrast, the English listeners showed similar response time, proportion of accuracy, and sensitivity index across the two blocks. These reflect integral processing among the Cantonese but not the English listeners. This finding motivates the dimensional transfer hypothesis. The hypothesis posits that L1 perceptual experience shapes the perceptual integrality (or nonintegrality) of foreign suprasegmental and segmental information.
Risk factors for Leptospira seropositivity in rural Northern Germany, 2019
Authors: Schmitz Saskia , Princk Christina , Meyer-Schlinkmann Kristin , Mylius Maren , Bier Nadja S. , Baillot Armin , Monazahian Masyar , Ulrich Rainer G. , Mayer-Scholl Anne , Dreesman Johannes
Published: December 2022

We investigated seroprevalence and factors associated with Leptospira spp. infections in humans in rural Northern Germany. Sera of 450 participants were tested for leptospira-reactive IgG antibodies by two enzyme-linked immunosorbent assays (ELISA). A narrow (specific) and a broad (sensitive) case definition were applied and results compared in the analysis. Personal data were collected via questionnaire and associations with the serostatus were investigated by multivariable logistic regression. The seroprevalence estimates were 1.6% (95%-confidence interval (CI) = 0.63–3.2) under the narrow and 4.2% (95%-CI = 2.6–6.5%) under the broad case definition. Few (14%) participants knew about the pathogen. No seropositive participant recalled a prior leptospirosis diagnosis. Spending more than two hours a week in the forest was significantly associated with anti-leptospira IgG in both models (broad case definition: adjusted odds ratio (aOR) = 2.8, 95%-CI = 1.2–9.1; narrow case definition: aOR = 11.1, 95%-CI = 1.3–97.1). Regular cleaning of storage rooms was negatively associated in the broad (aOR = 0.17, 95%-CI = 0.03–0.98) and touching a dead rodent in the past 10 years in the narrow case definition model (aOR = 0.23, 95%-CI = 0.05–1.04). Our findings support risk factors identified in previous investigations. To counter the low awareness for the pathogen, we recommend that health authorities communicate risks and preventive measures to the public by using target-group specific channels.
STRUCTURAL STABILITY OF MEANDERING-HYPERBOLIC GROUP ACTIONS
Authors: Kapovich Michael , Kim Sungwoon , Lee Jaejeong
Published: December 2022

In his 1985 paper, Sullivan sketched a proof of his structural stability theorem for differentiable group actions satisfying certain expansion-hyperbolicity axioms. In this paper, we relax Sullivan’s axioms and introduce a notion of meandering hyperbolicity for group actions on geodesic metric spaces. This generalization is substantial enough to encompass actions of certain nonhyperbolic groups, such as actions of uniform lattices in semisimple Lie groups on flag manifolds. At the same time, our notion is sufficiently robust, and we prove that meandering-hyperbolic actions are still structurally stable. We also prove some basic results on meandering-hyperbolic actions and give other examples of such actions.
Communication within families about advanced pediatric cancer: A qualitative study
Authors: Stanek Charis , Garcia Dana , Olsavsky Anna L. , Hill Kylie N. , Himelhoch Alexandra C. , Kenney Ansley E. , Humphrey Lisa , Olshefski Randal , Gerhardt Cynthia A. , Nahata Leena
Published: December 2022

Objectives

This qualitative study examined how families share information and feelings about advanced pediatric cancer from the perspective of both parents and children, as well as how these perspectives vary by child developmental stage.

Methods

Participants (24 mothers, 20 fathers, 23 youth [children and adolescents]) were from a larger longitudinal study at an academic pediatric hospital. Eligible youth had advanced cancer (physician-estimated prognosis of <60%, relapse, or refractory disease), were aged 5–19 years (>8 years old to participate independently), had an English-speaking parent, and lived within 140 miles of the hospital. Interviews were completed at enrollment and asked how families share information and emotions about the child’s cancer as a family.

Results

Saturation was reached at 20 interviews for mothers, fathers, and youth. Analyses revealed 4 major themes: (A) parents managing cancer-related information based on child age/developmental stage and processing styles of family members; (B) parents withholding poor prognosis information and emotions to maintain positivity; (C) lack of personal and familial emotion sharing; and (D) emotion sharing among their family and externally. Both parents and youth endorsed themes A, C, and D, but only parents endorsed theme B. Adolescents endorsed more themes than children. Parents of children (as opposed to adolescents) endorsed theme A more.

Significance of results

Although both parents and youth with advanced cancer were generally willing to talk about treatment, emotions were not consistently shared. Perspectives varied depending on the child’s developmental stage. Clinicians should assess parent and child information and emotion-sharing needs and provide individualized support to families regarding communication about advanced cancer.
A single case report of using Dummett’s systemic cognitive behavioural formulation to guide treatment of adolescent PTSD
Authors: O'Brien-Venus Bethany , Haines Cara
Published: December 2022

Trauma-focused CBT (TF-CBT) is recommended by NICE for adolescents with post-traumatic stress disorder (PTSD). Whilst caregiver involvement is recommended, no specific guidance on the nature of involvement is provided although it is important that involvement takes account of the nature of the trauma. This case report details how Dummett’s systemic CBT formulation was used to plan an intervention such that systemic sessions were included in TF-CBT treatment of an adolescent female with PTSD which arose following interpersonal trauma. Trauma symptoms, trauma cognitions and depressive symptoms were measured throughout, with trauma symptoms showing clinically significant change over the course of therapy. Clinical implications are considered regarding the applicability of systemic CBT formulation and the inclusion of systemic sessions within TF-CBT for adolescents whose traumas arose interpersonally.

Key learning aims

(1)

To be able to incorporate systemic factors into a formulation of the maintenance of PTSD for adolescents using Dummett’s systemic cognitive behavioural formulation.

(2)

To identify systemic interventions that may facilitate change in interactions between adolescents and parental figures and change in trauma appraisals.
Modulation Effects of Mesoscale Eddies on Sea Surface Wave Fields in the South China Sea Derived From a Wave Spectrometer Onboard the China‐France Ocean Satellite
Authors: Tan K. , Xie L. , Bai P. , Zheng Q. , Li J. , Xu Y. , Li M.
Published: December 2022

This study aims to examine the modulation effects of mesoscale eddies on sea surface wave fields in the South China Sea using data measured by a wave spectrometer named Surface Wave Investigation and Monitoring onboard the China‐France Ocean Satellite from July 2019 to August 2021. The statistical results show that the significant wave heights (SWHs) decrease (increase) from inside to outside of warm (cold) eddies, while the wavelengths have minimum values at the eddy edge in all cases. In cases of strong warm eddies, the maximum variations in SWH, wavelength, and wave direction caused by mesoscale eddy modulation reach up to 18%, 24%, and 28.4°, respectively. The eddy modulation on wave parameters is stronger at low sea states. The correlation analysis reveals that the wave parameter variations across eddies result from the eddy current shear and the direction difference between the eddy current and the waves. The dynamic analysis indicates that the deformation term of the eddy current is a dominant term affecting the SWH at the eddy edge, and the eddy current divergence and its product with wave direction determine the wavelength variation. The eddy vorticity deflects the wave direction by approximately 2°–3°, and the wave‐eddy angle and eddy‐modulated wind variation also contribute to the wave direction variation. The background current‐wave interaction is negligible in the eddy cases studied.
Symptoms of Performance Degradation During Multi‐Annual Drought: A Large‐Sample, Multi‐Model Study
Authors: Trotter Luca , Saft Margarita , Peel Murray C. , Fowler Keirnan J. A.
Published: December 2022

Hydrologic models are essential tools to understand and plan for the effect of changing climates; however, they underperform in transitory climate conditions. Existing research identifies models' inadequacy to perform during prolonged drought, but falls short on pinpointing which specific aspects of model performance are affected. We study five conceptual rainfall‐runoff models and their performance in 155 Australian catchments which recently experienced a 13‐year long drought. We use a wide range of performance metrics and a methodology based on ranked differences to a benchmark to fairly compare levels of degradation across metrics and periods. We show model performance degrading extensively during and after the drought, largely driven by overestimation of flow. Representation of shape and variability of hydrograph and flow‐duration curve are more resilient to the prolonged dry climate and rarely more degraded during the multi‐annual drought that on isolated dry years in the pre‐drought record. Conversely, volumetric error suffers from significant exacerbation over the multiple subsequent dry years. This indicates that catchment retention times and rates of storage depletion storage are significantly less affected by the drought than amounts of streamflow produced, pointing to a mismatch between reduction of influxes and out‐fluxes during the drought. We also identify a deficiency of models to delay and remove flow before it reaches the stream and keep track of moisture deficits over multiple dry seasons. By promoting rigorous investigation of models' shortcomings, we hope to foster the development of more robust model structures and/or calibration frameworks to improve applicability within climate change scenarios.
Wave Field Properties in Tropical Cyclones From the Spectral Observation of the CFOSAT/SWIM Spaceborne Instrument
Authors: Le Merle E. , Hauser D. , Yang C.
Published: December 2022

Tropical cyclones (TCs) are extreme events that generate, because of their movement, complex wave fields. The Surface Wave Investigation and Monitoring (SWIM) instrument is a real aperture radar that provides unprecedented detailed information about the waves with dominant wavelength between 70 and 500 m in all directions at the global scale. In this study we collocated 3 years of SWIM data with 67 TCs in the Northern Hemisphere to analyze the impact of the TC characteristics on the wave field. TCs have been classified into three different classes (slow, moderate speed, and fast) estimated based on the ratio between the maximum sustained wind and the displacement velocity. In order to analyze the characteristics of the wave field in the space domain, the observations have been separated according to the distance with the TC center and the quadrant. The results show that the characteristics of the TCs impact the wave field: the more favorable conditions for trapped wave phenomenon appears to be under moderate speed TC conditions. In slow and moderate speed TCs, close to the center the directional spectra are mono‐modal and tend to become bi‐ or multi‐modal when the distance to the center increases whereas in fast‐moving TCs, the directional spectra are always bi‐ or multi‐modal. Omni‐directional spectra show similarities with fetch‐limited spectra in slow and moderate speed TCs whereas in fast‐moving TCs, because of the presence of mixed‐sea, the decrease of energy with frequency is less steep than in fetch‐limited conditions.
Immunogenicity and risks associated with impaired immune responses following SARS-CoV-2 vaccination and booster in hematologic malignancy patients: an updated meta-analysis
Authors: Uaprasert Noppacharn , Pitakkitnukun Palada , Tangcheewinsirikul Nuanrat , Chiasakul Thita , Rojnuckarin Ponlapat
Published: December 2022

Patients with hematologic malignancies (HM) have demonstrated impaired immune responses following SARS-CoV-2 vaccination. Factors associated with poor immunogenicity remain largely undetermined. A literature search was conducted using PubMed, EMBASE, Cochrane, and medRxiv databases to identify studies that reported humoral or cellular immune responses (CIR) following complete SARS-CoV-2 vaccination. The primary aim was to estimate the seroconversion rate (SR) following complete SARS-CoV-2 vaccination across various subtypes of HM diseases and treatments. The secondary aims were to determine the rates of development of neutralizing antibodies (NAb) and CIR following complete vaccination and SR following booster doses. A total of 170 studies were included for qualitative and quantitative analysis of primary and secondary outcomes. A meta-analysis of 150 studies including 20,922 HM patients revealed a pooled SR following SARS-CoV-2 vaccination of 67.7% (95% confidence interval [CI], 64.8–70.4%; I2 = 94%). Meta-regression analysis showed that patients with lymphoid malignancies, but not myeloid malignancies, had lower seroconversion rates than those with solid cancers (R2 = 0.52, P < 0.0001). Patients receiving chimeric antigen receptor T-cells (CART), B-cell targeted therapies or JAK inhibitors were associated with poor seroconversion (R2 = 0.39, P < 0.0001). The pooled NAb and CIR rates were 52.8% (95% CI; 45.8–59.7%, I2 = 87%) and 66.6% (95% CI, 57.1–74.9%; I2 = 86%), respectively. Approximately 20.9% (95% CI, 11.4–35.1%, I2 = 90%) of HM patients failed to elicit humoral and cellular immunity. Among non-seroconverted patients after primary vaccination, only 40.5% (95% CI, 33.0–48.4%; I2 = 87%) mounted seroconversion after the booster. In conclusion, HM patients, especially those with lymphoid malignancies and/or receiving CART, B-cell targeted therapies, or JAK inhibitors, showed poor SR after SARS-CoV-2 vaccination. A minority of patients attained seroconversion after booster vaccination. Strategies to improve immune response in these severely immunosuppressed patients are needed.
ABX-1431 inhibits the development of endometrial adenocarcinoma and reverses progesterone resistance by targeting MGLL
Authors: Ma Xiaohong , Xia Min , Wei Lina , Guo Kui , Sun Rui , Liu Yao , Qiu Chunping , Jiang Jie
Published: December 2022

Endometrial cancer is a common gynecological malignancy. With the onset of EC patients younger, conservative treatment with progesterone has become an important option for patients trying to preserve reproductive function. However, progesterone resistance is a key factor affecting the efficacy of therapy and it is urgent to clarify the mechanism so as to propose a potential target and inhibit the development of endometrial adenocarcinoma and progesterone resistance. MGLL, an important factor involved in lipid mobilization, is overexpressed in many tumors, however the biological function of MGLL in the development of endometrial adenocarcinoma and the process of progesterone resistance still remains unclear. In this study, we first found MGLL was highly expressed in progesterone resistant samples of endometrial adenocarcinoma, and then we verified its expression was increased in endometrial adenocarcinoma. Through in vitro and in vivo experiments, we demonstrated that overexpression of MGLL promoted tumor proliferation, metastasis and the occurrence of progestogen resistance, knockdown MGLL inhibited tumor proliferation, metastasis and reversed progestogen resistance. In addition, knockdown of MGLL can sensitize endometrial adenocarcinoma cells to progesterone, possibly by affecting ROS generation and reducing the expression of AKR1C1. Finally, it was verified that ABX-1431, MGLL inhibitor, reversed progesterone resistance and enhanced the sensitivity of endometrial adenocarcinoma to progesterone both in vitro and in vivo. In conclusion, the high expression of MGLL is involved in the occurrence and development of endometrial adenocarcinoma and progesterone resistance. Targeted inhibition of MGLL by inhibitors may be an effective method for the treatment of progesterone resistance in endometrial adenocarcinoma.
A zebrafish HCT116 xenograft model to predict anandamide outcomes on colorectal cancer
Authors: Maradonna Francesca , Fontana Camilla M. , Sella Fiorenza , Giommi Christian , Facchinello Nicola , Rampazzo Chiara , Caichiolo Micol , Hoseinifar Seyed Hossein , Dalla Valle Luisa , Van Doan Hien , Carnevali Oliana
Published: December 2022

Colon cancer is one of the leading causes of death worldwide. In recent years, cannabinoids have been extensively studied for their potential anticancer effects and symptom management. Several in vitro studies reported anandamide’s (AEA) ability to block cancer cell proliferation and migration, but evidence from in vivo studies is still lacking. Thus, in this study, the effects of AEA exposure in zebrafish embryos transplanted with HCT116 cells were evaluated. Totally, 48 hpf xenografts were exposed to 10 nM AEA, 10 nM AM251, one of the cannabinoid 1 receptor (CB1) antagonist/inverse agonists, and to AEA + AM251, to verify the specific effect of AEA treatment. AEA efficacy was evaluated by confocal microscopy, which demonstrated that these xenografts presented a smaller tumor size, reduced tumor angiogenesis, and lacked micrometastasis formation. To gain deeper evidence into AEA action, microscopic observations were completed by molecular analyses. RNA seq performed on zebrafish transcriptome reported the downregulation of genes involved in cell proliferation, angiogenesis, and the immune system. Conversely, HCT116 cell transcripts resulted not affected by AEA treatment. In vitro HCT116 culture, in fact, confirmed that AEA exposure did not affect cell proliferation and viability, thus suggesting that the reduced tumor size mainly depends on direct effects on the fish rather than on the transplanted cancer cells. AEA reduced cell proliferation and tumor angiogenesis, as suggested by socs3 and pcnp mRNAs and Vegfc protein levels, and exerted anti-inflammatory activity, as indicated by the reduction of il-11a, mhc1uba, and csf3b mRNA. Of note, are the results obtained in groups exposed to AM251, which presence nullifies AEA’s beneficial effects. In conclusion, this study promotes the efficacy of AEA in personalized cancer therapy, as suggested by its ability to drive tumor growth and metastasis, and strongly supports the use of zebrafish xenograft as an emerging model platform for cancer studies.
TAZ promotes osteogenic differentiation of mesenchymal stem cells line C3H10T1/2, murine multi-lineage cells lines C2C12, and MEFs induced by BMP9
Authors: Huang Huakun , Lu Qiuping , Ye Caihong , Wei Mengqi , Yang Chunmei , Zhang Lulu , Huang Yanran , Luo Xiaoji , Luo Jinyong
Published: December 2022

Bone morphogenetic protein 9 (BMP9), also named as growth differentiation factor 2 (GDF-2), is the strongest cytokine that promotes osteogenic differentiation in the BMP family, and has broad clinical application value. Nevertheless, the mechanism of BMP9 promotes osteogenic differentiation remain unclear. TAZ, a transcriptional co-activator, has great effects on cell proliferation, differentiation, and stem cell self-renewal. In this research, we investigated the effects of TAZ in BMP9-induced osteogenic differentiation of mesenchymal stem cell line C3H10T1/2 (MSCs) and murine multi-lineage cell lines C2C12 and MEFs (MMCs) and explored its possible mechanisms. This study has found that BMP9 induces the expression of TAZ and promotes its nuclear translocation. Meanwhile, our study found that Ad-TAZ and TM-25659, a TAZ agonist, can enhance the osteogenic differentiation of MSCs and MMCs induced by BMP9. Conversely, Ad-si-TAZ and verteporfin, an inhibitor of TAZ, have the contradictory effect. Likewise, the promotion of TAZ to the BMP9-induced ectopic bone formation in vivo was confirmed by the subcutaneous transplantation of MSCs in nude mice. Furthermore, we have detected that TAZ might increase the levels of the phosphorylation of Smad1/5/8, p38, ERK1/2, and JNK induced by BMP9. Additionally, we also found that TAZ increased the total protein level of β-catenin induced by BMP9. In summary, our results strongly indicated that TAZ will promote the osteogenic differentiation in MSCs and MMCs induced by BMP9 through multiple signal pathways.
A cyclic heptapeptide-based hydrogel boosts the healing of chronic skin wounds in diabetic mice and patients
Authors: Fu Zhe , Sun Huiling , Wu Yutong , Li Chao , Wang Yinglei , Liu Yixiang , Li Yilin , Nie Junxu , Sun Dandan , Zhang Yingxuan , Liu Naixin , Guo Kun , Yin Saige , Jia Qiuye , Yang Ying , He Li , Wang Ying , Yang Xinwang
Published: December 2022

The combined use of peptides, nanomaterials, and hydrogels is a promising strategy for chronic skin wound healing, which remains a huge clinical challenge. Here, we optimized the RL-QN15 peptide, which was shown to be a pro-healing drug candidate in our previous research, to obtain the cyclic heptapeptide (CyRL-QN15) with considerable therapeutic potency against skin wounds. Furthermore, a Zn2+-crosslinked sodium alginate (ZA) hydrogel containing hollow polydopamine (HPDA) nanoparticles loaded with CyRL-QN15 (HPDAlCyRL-QN15/ZA hydrogel) was prepared and characterized, which significantly enhanced the pro-healing potency of CyRL-QN15. At the cellular level, this nontoxic hydrogel accelerated the proliferation, migration, tube formation, and scratch healing of skin cells, regulated the secretion of cytokines from macrophages, directly scavenged free radicals, and decreased reactive oxygen species. Moreover, the HPDAlCyRL-QN15/ZA hydrogel significantly accelerated the healing of full-thickness skin wounds in type 2 diabetic mice by promoting the transition of macrophages to the M2 phenotype to reduce inflammation and cause re-epithelialization, formation of granulation tissue, deposition of collagen, and angiogenesis. Of note, the hydrogel also facilitated wound healing of diabetic patient skin cultured ex vivo. Overall, the HPDAlCyRL-QN15/ZA hydrogel presents a novel therapeutic strategy for clinical chronic skin wound (diabetic ulcer) healing.
Topical cyclosporine A cationic ophthalmic emulsion in paediatric vernal keratoconjunctivitis: pooled analysis of randomised NOVATIVE and VEKTIS trials
Authors: Leonardi Andrea , Doan Serge , Aragona Pasquale , Amrane Mourad , Ismail Dahlia , Montero Jesús , Németh János , Bremond-Gignac Dominique
Published: December 2022

Background/Objectives

Cyclosporine A cationic ophthalmic emulsion (CsA CE) was evaluated in paediatric and adolescent patients with vernal keratoconjunctivitis (VKC) in the NOVATIVE (NCT00328653) and VEKTIS (NCT01751126) trials. The similarity of these studies permitted pooled assessment of the effect of CsA CE on corneal damage as well as safety and tolerability.

Subjects/Methods

Pooled outcomes were assessed for the first 28 days of treatment. In NOVATIVE, 118 patients were randomised to 4 times daily (QID) CsA CE 0.05%, 0.1%, or vehicle eye drops. In VEKTIS, 169 patients were randomised to CsA CE 0.1% QID or twice daily (BID) or vehicle. For these analyses, treatment groups comprised: (1) pooled CsA CE 0.1% QID arms (high-dose; n = 96); (2) pooled CsA CE 0.05% QID arm from NOVATIVE and CsA CE 0.1% BID data from VEKTIS (low-dose; n = 93); and (3) pooled vehicle QID arms (vehicle; n = 98).

Results

Changes from baseline to day 28 (mean ± standard deviation) in corneal fluorescein staining (CFS) scores for CsA CE high-dose, low-dose, and vehicle groups were −1.6 ± 1.47 (95% CI: −0.9, −0.1; p = 0.0124 vs vehicle), −1.7 ± 1.39 (95% CI: −1.1, −0.3; p = 0.0015 vs vehicle), and −1.0 ± 1.55, respectively. Adverse events (AEs) of any type were reported in 37.5%, 34.4%, and 37.8% of the high-dose, low-dose, and vehicle groups, respectively. Most were mild or moderate in severity.

Conclusions

CsA CE significantly decreased corneal damage and was safe and well tolerated in patients with VKC. These data support CSA CE as a treatment option for the management of VKC.
Ligand recognition and activation of neuromedin U receptor 2
Authors: Zhao Wenli , Zhang Wenru , Wang Mu , Lu Minmin , Chen Shutian , Tang Tingting , Schnapp Gisela , Wagner Holger , Brennauer Albert , Yi Cuiying , Chu Xiaojing , Han Shuo , Wu Beili , Zhao Qiang
Published: December 2022

Neuromedin U receptor 2 (NMU2), an emerging attractive target for treating obesity, has shown the capability in reducing food intake and regulating energy metabolism when activated. However, drug development of NMU2 was deferred partially due to the lack of structural information. Here, we present the cryo-electron microscopy (cryo-EM) structure of NMU2 bound to the endogenous agonist NmU-25 and Gi1 at 3.3 Å resolution. Combined with functional and computational data, the structure reveals the key factors that govern the recognition and selectivity of peptide agonist as well as non-peptide antagonist, providing the structural basis for design of novel and highly selective drugs targeting NMU2. In addition, a 25-degree rotation of Gi protein in reference to NMU2 is also observed compared in other structures of class A GPCR—Gi complexes, suggesting heterogeneity in the processes of G protein-coupled receptors (GPCRs) activation and G protein coupling.