bluuebunny/crossref_metadata_2025 huggingface dataset:
The doctrine of just war in the development of Christian thinkers of the Middle Ages
Authors:   LLC ", Borysova Olga ,   Kharkiv University"
Published: July 2022

Based on the analysis of the works of medieval Christian thinkers, the article highlights the principles of the Christian doctrine of „just war”, which was formed during the Middle Ages and did not undergo significant changes until the Second Vatican Council (1963-1965). The urgency of the topic lies in the fact that many armed conflicts are now religious in nature, including the latest Russian-Ukrainian war, which is being waged under the slogan of the „Russian world” ideology, developed by Moscow Patriarch Kirill. Such and similar consecration of wars and armed conflicts by religious organizations forces us to turn to political and legal concepts, which seem to have long since disappeared, but they now, as it turns out, acquire a new meaning. The article reveals the purpose of the study, its methods and the state of study in the literature. The main part of the article shows that, although the concept of „just war” dates back to antiquity, the architects of the doctrine of just war were medieval Christian authors – Ambrose of Milan, Aurelius Augustine, Thomas Aquinas, Francisco de Vitoria. The article considers the contribution of each of these authors to the development of the doctrine, emphasizes that, in fact, the concept of „doctrine” should be attributed to the creative legacy of Thomas Aquinas in the concept of „just war”, and noted that this doctrine became the basis of Catholic doctrine of war. which has remained unchanged for many centuries. Later scholastics, and above all Francisco de Vitoria, supplemented the doctrine of just war with their research, without affecting its foundations developed by Thomas Aquinas. However, it is noted that in modern warfare, the concept of „justice” is distorted, the understanding of just war in the Christian religious and ethical tradition has been forgotten, and some church leaders even suggest abandoning the doctrine of just war. The author believes that everything needs to be redesigned, raising the whole layer of works on the theme of just war, starting with ancient and medieval authors. The article concludes with conclusions and formulations of prospects for further research in this area.
New book of a famous historian (Review of the book: Ofitsynskyy R. Zakarpattia long ago. Historical essay. Uzhgorod: Rik-U, 2022. 380 p.)
Authors:   State Institution Luhansk Taras Shevchenko National University, Naboka Oleksandr
Published: July 2022

The article is an extended and detailed review of a new book of the famous Ukrainian scientist and historian from Zakarpattia Roman Ofitsynskyy. The publication is a collection of local lore essays and interviews on various important aspects of Zakarpattia regional history, written by the scientist at different times. The peer-reviewed book structurally has five main parts. First, there is a generalized discussion of the interpretation and falsification of the past through the prism of the concept of „love for the native land”. Reflections on state borders, German and French factors have been focused on the long-term, mostly in the last millennium. „Long XIX century” is personalized by the figures of Mikhailo Baludyanskyy, Yurii Venelin, Vasil Dovgovich, „people’s diplomacy” – the spread of the legacy of Taras Shevchenko and interregional contacts. World War I opens a new era: the course of hostilities, economic and social consequences, and preserved monuments are highlighted. The interwar period is viewed through the prism of the Hutsul Republic, through the eyes of women of Subcarpathian Rus, with an emphasis on the Polish contribution and political visions of Augustyn Voloshin. It should be noted that the new book of Professor Roman Ofitsynskyy „Zakarpattia long ago” was publicly presented on April 20, 2022 in the information and resource center „Window on America” ​​of the Zakarpattia Regional Universal Scientific Library named after Fedor Potushnyak. There was a video broadcast on the library’s Facebook page, and fifty additional history teachers joined Google Meet.
Leishmania: case management and UK transmission
Authors: Wright Ian
Published: July 2022

Leishmania are vector-borne protozoan parasites that cause a wide range of clinical disease (leishmaniosis). Leishmania infantum is the species mainly causing leishmaniosis in European cats and dogs, and has zoonotic potential. Sandflies are the principal vector of transmission, but non-vectorial routes such as venereal, transplacental and blood transfusion have been described. There is no gold-standard diagnostic test, so leishmaniosis is diagnosed using a combination of methods alongside relevant clinical signs. Early diagnosis is essential for assessing prognosis, successfully managing the disease and minimising transmission. This article discusses the epidemiology, diagnosis and management of leishmaniosis in dogs and cats, and the risk of it becoming established in the UK.
Communication surrounding initiation and withdrawal of non-invasive ventilation in adults with motor neurone disease
Authors: Chapman Charlotte , Bayes Sara , Sim Moira
Published: July 2022

Background:

Motor neurone disease causes respiratory weakness that can lead to death. While non-invasive ventilation relieves symptoms, there are complex issues to consider prior to commencement.

Aim:

To identify what is known and understood about the clinician communication of non-invasive ventilation by people with motor neurone disease.

Method:

The Joanna Briggs Institute approach to systematic reviews was followed for literature retrieval and selection.

Data sources:

Research literature published between 1990–2019 in English from the Medline, CINAHL, ProQuest Research Library and the Cochrane Library of Systematic Reviews databases were used.

Results:

A total of two themes emerged: communication challenges doctors face when discussing non-invasive ventilation withdrawal, and the importance of well-timed, effective communication by clinicians–specifically the influence clinicians have on family decision-making.

Conclusions:

Guidance on communications around palliative care, non-invasive ventilation introduction and withdrawal exist, however implementation is often not straightforward. Research into the communication surrounding non-invasive ventilation from those living with motor neuron disease, their families and clinicians is required to inform guideline implementation and practice.
Parallel trapping of multiple nanoparticles using a quasi-bound state in the continuum mode
Authors: Wang Jinzhi , Han Zhe , Wang Chao , Tian Huiping
Published: July 2022

In this work, we put forward an all-dielectric nanotweezer using a quasi-bound state in the continuum (quasi-BIC) mode to trap nanoparticles with a radius of 10 nm. The quasi-BIC mode provides not only a very high electric field enhancement but also a high quality factor (

Q

-factor), which gives it potential for the trapping of nanoparticles with low laser power and high stability. The simulation results show that when the input intensity is

1

m
W

/

µ

m

2

, the maximum optical trapping force of the 10 nm particles is 2.24 pN, and the maximum trapping potential is

29.08

k
B

T

. Furthermore, the proposed nanotweezer array provides multiple optical hotspots with high field confinement and enhancement, resulting in multiple trapping sites for the parallel trapping of multiple nanoparticles. The high-throughput trapping of nanoparticles provides a good foundation for studying biological cells and protein molecules, especially for the heterogeneity of cells and the large-scale parallel analyses of basic drugs.
Photonic sampling analog-to-digital conversion based on time and wavelength interleaved ultra-short optical pulse train generated by using monolithic integrated LNOI intensity and phase modulator
Authors: Li Zhengkai , Wang Xuanhao , Zhang Yujia , Shang Chenglin , Lyu Weiqiang , Lyu Yanjia , Zeng Cheng , Zhang Zhiyao , Zhang Shangjian , Li Heping , Xia Jinsong , Liu Yong
Published: July 2022

High-speed analog-to-digital conversion (ADC) is experimentally demonstrated by employing a time and wavelength interleaved ultra-short optical pulse train to achieve photonic sampling and using wavelength division demultiplexing to realize speed matching between the fast optical front-end and the slow electronic back-end. The sampling optical pulse train is generated from a cavity-less ultra-short optical pulse source involving a packaged device that monolithically integrates an intensity modulator and a phase modulator into a chip based on lithium niobate on insulator (LNOI). In the experiment, the fiber-to-fiber insertion loss of the packaged modulation device is measured to be 6.9 dB. In addition, the half-wave voltages of the Mach-Zehnder modulator and the phase modulator in the LNOI-based modulation device are measured to be 3.6 V and 3.4 V at 5 GHz, respectively. These parameters and the device size are superior to those based on cascaded commercial devices. Through using the packaged modulation device, two ultra-short optical pulse trains centered at 1541.40 nm and 1555.64 nm are generated with time jitters of 19.2 fs and 18.9 fs in the integral offset frequency range of 1 kHz to 10 MHz, respectively, and are perfectly time interleaved into a single pulse train with a repetition rate of 10 GHz and a time jitter of 19.8 fs. Based on the time and wavelength interleaved ultra-short optical pulse train, direct digitization of microwave signals within the frequency range of 1 GHz to 40 GHz is demonstrated by using a two-channel wavelength demultiplexing photonic ADC architecture, where the effective number of bits are 5.85 bits and 3.75 bits for the input signal at 1.1 GHz and 36.3 GHz, respectively.
Ultra-long anti-diffracting beam volume imaging using a single-photon excitation microscope
Authors: Guo Yong , Han Hongyi , Wang Luwei , Zhu Yinru , Yang Zhigang , Weng Xiaoyu , Yan Wei , Qu Junle
Published: July 2022

We studied a novel volumetric single-photon excitation microscope with an ultralong anti-diffracting (UAD) beam as illumination. Volumetric fluorescence image direct mapping showed that the axial imaging range of the UAD beam was approximately 14 times and 2 times that of conventional Gaussian and Airy beams, respectively, while maintaining a narrow lateral width. We compared the imaging capabilities of the Gaussian, Airy, and UAD modes through a strongly scattering environment mixed with fluorescent microspheres and agarose gel. Thick samples were scanned layer by layer in the Gaussian, Airy, and UAD modes, and then the three-dimensional structural information was projected onto a two-dimensional image. Benefiting from the longer focal length of the UAD beam, a deeper axial projection was provided, and the volume imaging speed was vastly increased. To demonstrate the performances of the UAD microscope, we performed dynamic volumetric imaging on the cardiovascular system of zebrafish labeled with green fluorescent proteins in the three modes and dynamically monitored substance transport in zebrafish blood vessels. In addition, the symmetrical curve trajectory of the UAD beam and the axial depth of the lateral position can be used for localization of micro-objects.
Sensitive ultrawideband transparent PVDF-ITO ultrasound detector for optoacoustic microscopy
Authors: Liu Yu-Hang , Kurnikov Alexey , Li Weiye , Kazakov Vyacheslav , Ni Ruiqing , Subochev Pavel , Razansky Daniel
Published: July 2022

An ultrasound detection scheme based on a transparent polyvinylidene-fluoride indium-tin-oxide (PVDF-ITO) piezoelectric film is developed for ultrawideband sensitive detection of optoacoustic (OA) signals down to a noise equivalent pressure (NEP) of 8.4 Pa over an effective detection bandwidth extending beyond 30 MHz. The high signal-to-noise ratio and low noise performance are facilitated by employing a two-stage amplifier structure. The PVDF-ITO detector is directly mounted on a commercial high numerical aperture objective lens of a scanning optical resolution OA microscopy system to obtain submicron resolution images without signal averaging, as demonstrated both in phantoms and in vivo measurements in mice. The transparent detection scheme further allows for the OA imaging modality to be easily integrated with other imaging techniques for diverse multi-modal biomedical imaging investigations.
Helix 8 in chemotactic receptors of the complement system
Authors: Wisniewski Szymon , Dragan Paulina , Makal Anna , Latek Dorota
Published: July 2022

Host response to infection involves the activation of the complement system leading to the production of anaphylatoxins C3a and C5a. Complement factor C5a exerts its effect through the activation of C5aR1, chemotactic receptor 1, and triggers the G protein-coupled signaling cascade. Orthosteric and allosteric antagonists of C5aR1 are a novel strategy for anti-inflammatory therapies. Here, we discuss recent crystal structures of inactive C5aR1 in terms of an inverted orientation of helix H8, unobserved in other GPCR structures. An analysis of mutual interactions of subunits in the C5aR1—G protein complex has provided new insights into the activation mechanism of this distinct receptor. By comparing two C5aR receptors C5aR1 and C5aR2 we explained differences between their signaling pathways on the molecular level. By means of molecular dynamics we explained why C5aR2 cannot transduce signal through the G protein pathway but instead recruits beta-arrestin. A comparison of microsecond MD trajectories started from active and inactive C5aR1 receptor conformations has provided insights into details of local and global changes in the transmembrane domain induced by interactions with the Gα subunit and explained the impact of inverted H8 on the C5aR1 activation.
Ten simple rules to host an inclusive conference
Authors: Joo Rocío , Sánchez-Tapia Andrea , Mortara Sara , Bellini Saibene Yanina , Turner Heather , Hug Peter Dorothea , Morandeira Natalia Soledad , Bannert Matt , Almazrouq Batool , Hare Elizabeth , Ación Laura , Narváez-Gómez Juan Pablo , Alfaro Córdoba Marcela , Marini Federico , Giordano Rita , Canelón Silvia , Ebou Anicet , Upadhya Adithi R. , Chávez Joselyn , Ravi Janani
Published: July 2022

Conferences are spaces to meet and network within and across academic and technical fields, learn about new advances, and share our work. They can help define career paths and create long-lasting collaborations and opportunities. However, these opportunities are not equal for all. This article introduces 10 simple rules to host an inclusive conference based on the authors’ recent experience organizing the 2021 edition of the useR! statistical computing conference, which attracted a broad range of participants from academia, industry, government, and the nonprofit sector. Coming from different backgrounds, career stages, and even continents, we embraced the challenge of organizing a high-quality virtual conference in the context of the Coronavirus Disease 2019 (COVID-19) pandemic and making it a kind, inclusive, and accessible experience for as many people as possible. The rules result from our lessons learned before, during, and after the organization of the conference. They have been written mainly for potential organizers and selection committees of conferences and contain multiple practical tips to help a variety of events become more accessible and inclusive. We see this as a starting point for conversations and efforts towards building more inclusive conferences across the world. * Translated versions of the English abstract and the list of rules are available in 10 languages in S1 Text: Arabic, French, German, Italian, Japanese, Korean, Portuguese, Spanish, Tamil, and Thai.
The spectrum of covariance matrices of randomly connected recurrent neuronal networks with linear dynamics
Authors: Hu Yu , Sompolinsky Haim
Published: July 2022

A key question in theoretical neuroscience is the relation between the connectivity structure and the collective dynamics of a network of neurons. Here we study the connectivity-dynamics relation as reflected in the distribution of eigenvalues of the covariance matrix of the dynamic fluctuations of the neuronal activities, which is closely related to the network dynamics’ Principal Component Analysis (PCA) and the associated effective dimensionality. We consider the spontaneous fluctuations around a steady state in a randomly connected recurrent network of stochastic neurons. An exact analytical expression for the covariance eigenvalue distribution in the large-network limit can be obtained using results from random matrices. The distribution has a finitely supported smooth bulk spectrum and exhibits an approximate power-law tail for coupling matrices near the critical edge. We generalize the results to include second-order connectivity motifs and discuss extensions to excitatory-inhibitory networks. The theoretical results are compared with those from finite-size networks and the effects of temporal and spatial sampling are studied. Preliminary application to whole-brain imaging data is presented. Using simple connectivity models, our work provides theoretical predictions for the covariance spectrum, a fundamental property of recurrent neuronal dynamics, that can be compared with experimental data.
Haisu: Hierarchically supervised nonlinear dimensionality reduction
Authors: VanHorn Kevin Christopher , Çobanoğlu Murat Can
Published: July 2022

We propose a novel strategy for incorporating hierarchical supervised label information into nonlinear dimensionality reduction techniques. Specifically, we extend t-SNE, UMAP, and PHATE to include known or predicted class labels and demonstrate the efficacy of our approach on multiple single-cell RNA sequencing datasets. Our approach, “Haisu,” is applicable across domains and methods of nonlinear dimensionality reduction. In general, the mathematical effect of Haisu can be summarized as a variable perturbation of the high dimensional space in which the original data is observed. We thereby preserve the core characteristics of the visualization method and only change the manifold to respect known or assumed class labels when provided. Our strategy is designed to aid in the discovery and understanding of underlying patterns in a dataset that is heavily influenced by parent-child relationships. We show that using our approach can also help in semi-supervised settings where labels are known for only some datapoints (for instance when only a fraction of the cells are labeled). In summary, Haisu extends existing popular visualization methods to enable a user to incorporate labels known a priori into a visualization, including their hierarchical relationships as defined by a user input graph.
Risk factors for stillbirth and neonatal mortality among participants in Mobile WACh NEO pilot, a two-way SMS communication program in Kenya
Authors: Hedstrom Anna B. , Choo Esther M. , Ronen Keshet , Wandika Brenda , Jiang Wenwen , Osborn Lusi , Batra Maneesh , Wamalwa Dalton , John-Stewart Grace , Kinuthia John , Unger Jennifer A.
Published: July 2022

Globally, 2.5 million neonates die and 2 million more are stillborn each year; the vast majority occur where access to life-saving care is limited. High quality, feasible interventions are needed to reach, educate and empower pregnant women and new mothers to improve care-seeking behaviors. Mobile WACh (Mobile solutions for Women’s and Children’s health) NEO is a human-computer hybrid mobile health (mHealth) system that allows for two-way short message service (SMS) communication between women and healthcare workers during the peripartum period. We performed a secondary prospective cohort analysis of data from the Mobile WACh NEO pilot study to determine maternal characteristics associated with neonatal death and stillbirth and examine participant messaging associated with these events. Pregnant women were enrolled at two Kenyan public health clinics between 28–36 weeks gestation. They received personalized, educational, action-oriented SMS messages during pregnancy and through 14 weeks postpartum. Participants could message the study at any time and study nurses responded. Standardized questionnaires assessed participant characteristics at baseline and 14 weeks postpartum. Outcomes were ascertained at study visits or by SMS report. Among 798 pregnant women enrolled, median age was 24 years [IQR 21, 29], 37% were primiparous and 92% used SMS as a primary mode of communication. Seventeen neonatal deaths and 13 stillbirths occurred. Older maternal age was associated with increased risk of stillbirth [aRR 1.12 (CI 1.02–1.24), p <0.05]. We found no significant predictors of neonatal death. Participant messaging to study nurse about concerns in the week preceding death was less common prior to infant death after discharge home from facility birth (9%) than prior to stillbirth (23%). We found limited predictors of neonatal death and stillbirth, suggesting identifying women prenatally for targeted support may not be a feasible strategy. Scarce messaging from mothers whose neonates died may reflect difficulties identifying illness or rapid deterioration and needs to be better understood to design and test interventions for this high-risk period. Messaging prior to stillbirth, while at similar levels as other periods, does not appear to have an impact as most women do not experience identifiable signs or symptoms prior to the event.
The impact of IOM recommendations on gestational weight gain among US women: An analysis of birth records during 2011–2019
Authors: Tennekoon Vidhura S.
Published: July 2022

The prevailing guidelines of the Institute of Medicine (IOM) of United States on gestational weight gain (GWG) are based on women’s prepregnancy body mass index (BMI) categories. Previous research has shown that the guidelines issued in 1990 and revised in 2009 had no effect. We investigate the effectiveness of new guidelines issued in 2009 analyzing the records of all singleton births in the U.S. during 2011–2019 (34.0 million observations). We use the discontinuity in recommended guidelines at the threshold values of BMI categories in a regression discontinuity (RD) research design to investigate the effect of IOM guidelines on GWG. We also use an RD analysis in a difference in difference (DID) framework where we compare the effect on women who had any prenatal care to others who did not receive prenatal care. The naïve RD estimator predicts an effect in the expected direction at the threshold BMI values of 18.5 and 25.0 but not at 30.0. After the DID based correction, the RD analyses show that the GWG, measured in kg, drop at the BMI values of 18.5, 25.0 and 30.0 by 0.189 [CI: 0.341, 0.037], 0.085 [CI: 0.179, -0.009] and 0.200 [CI: 0.328, 0.072] respectively when the midpoint of the recommended range in kg drops by 1.5, 4.5 and 2.25. This implies a responsiveness of 12.6%, 1.9% and 8.9% respectively to changes in guidelines at these BMI values. The findings show that the national guidelines have induced some behavioral changes among US women during their pregnancy resulting in a change in GWG in the expected direction. However, the magnitude of the change has not been large compared to the expectations, implying that the existing mechanisms to implement these guidelines have not been sufficiently strong.
Melatonin accelerates the developmental competence and telomere elongation in ovine SCNT embryos
Authors: Nadri Parisa , Ansari-Mahyari Saeid , Jafarpour Farnoosh , Mahdavi Amir Hossein , Tanhaei Vash Nima , Lachinani Liana , Dormiani Kianoush , Nasr-Esfahani Mohammad Hossein
Published: July 2022

SCNT embryos suffer from poor developmental competence (bothin vitroandin vivo) due to various defects such as oxidative stress, incomplete epigenetic reprogramming, and flaws in telomere rejuvenation. It is very promising to ameliorate all these defects in SCNT embryos by supplementing the culture medium with a single compound. It has been demonstrated that melatonin, as a multitasking molecule, can improve the development of SCNT embryos, but its function during ovine SCNT embryos is unclear. We observed that supplementation of embryonic culture medium with 10 nM melatonin for 7 days accelerated the rate of blastocyst formation in ovine SCNT embryos. In addition, the quality of blastocysts increased in the melatonin-treated group compared with the SCNT control groups in terms of ICM, TE, total cell number, and mRNA expression of NANOG. Mechanistic studies in this study revealed that the melatonin-treated group had significantly lower ROS level, apoptotic cell ratio, and mRNA expression of CASPASE-3 and BAX/BCL2 ratio. In addition, melatonin promotes mitochondrial membrane potential and autophagy status (higher number of LC3B dots). Our results indicate that melatonin decreased the global level of 5mC and increased the level of H3K9ac in the treated blastocyst group compared with the blastocysts in the control group. More importantly, we demonstrated for the first time that melatonin treatment promoted telomere elongation in ovine SCNT embryos. This result offers the possibility of better development of ovine SCNT embryos after implantation. We concluded that melatonin can accelerate the reprogramming of telomere length in sheep SCNT embryos, in addition to its various beneficial effects such as increasing antioxidant capacity, reducing DNA damage, and improving the quality of derived blastocysts, all of which led to a higherin vitrodevelopment rate.
Gait alterations in Parkinson’s disease at the stage of hemiparkinsonism—A longitudinal study
Authors: Marković Vladana , Stanković Iva , Radovanović Saša , Petrović Igor , Ječmenica Lukić Milica , Dragašević Mišković Nataša , Svetel Marina , Kostić Vladimir
Published: July 2022

Background

Progressive gait impairment in Parkinson’s disease (PD) leads to significant disability. Quantitative gait parameters analysis provides valuable information about fine gait alterations.

Objectives

To analyse change of gait parameters in patients with early PD at the stage of hemiparkinsonism and after 1 year of follow up, taking into account clinical asymmetry.

Methods

Consecutive early PD outpatients with strictly unilateral motor features underwent clinical and neuropsychological assessment at the study entry and after 1 year of follow up. Gait was assessed with GAITRite walkway using dual-task methodology. Spatiotemporal gait parameters (step time and length, swing time and double support time) and their coefficients of variation (CV), gait velocity and heel-to-heel base support were evaluated.

Results

We included 42 PD patients with disease duration of 1.3 years (±1.13). Progression of motor and non-motor symptoms, without significant cognitive worsening, was observed after 1 year of follow up. Significant shortening of the swing time, prolongation of the double support and increase of their CVs were observed during all task conditions similarly for most parameters on symptomatic and asymptomatic bodysides, except for CV for the swing time under the combined task.

Conclusion

Alterations of the swing time and double support time are already present even at the asymptomatic body side, and progress similarly, or even at faster pace, at this side, despite dopaminergic treatment These parameters deserve further investigation in larger, prospective studies to address their potential to serve as markers of progression in interventional disease modifying trials with early PD patients.
A framework for effective face-mask contact modeling based on finite element analysis for custom design of a facial mask
Authors: Kwon Yun-Jae , Kim Jin-Gyun , Lee Wonsup
Published: July 2022

A novel contact model is presented to efficiently solve a face-mask contact problem by using the finite element (FE) method for the optimized design of a custom facial mask. Simulation of contact pressure for various mask designs considering material properties of the face allows virtual evaluation of the suitability of a mask design for a person’s face without conducting empirical measurement of the face-mask contact pressure. The proposed contact model is accomplished by combining three approaches to reduce the calculation cost of simulating the face-mask contact: (1) use of a simplified and modifiable mask model that applies a spline curve to design points; (2) reduction of the FE model of the face by applying static condensation; and (3) application of a contact assumption that uses the Lagrange multiplier method. A numerical case study of a medical mask design showed that the proposed model could calculate the face-mask contact pressure efficiently (0.0448 sec per design). In a pilot usability experiment, the measured contact pressure was found similar values (range of mean contact pressure: 0.0093 ~ 0.0150 MPa) to the estimated values (range of mean contact pressure: 0.0097 ~ 0.0116 MPa).
Effectiveness of couple education and counseling on knowledge, attitude and uptake of cervical cancer screening service among women of child bearing age in Southern Ethiopia: A cluster randomized trial protocol
Authors: Ayanto Samuel Yohannes , Belachew Tefera , Wordofa Muluemebet Abera
Published: July 2022

Background

Cervical cancer occurred nearly in 570 000 women and 311 000 women died from the disease worldwide in 2018. Of the new cases diagnosed globally in 2012, approximately 85% of the burden took place in low- and middle-income countries. Human Papilloma virus is the necessary cause for the development of cervical cancer and the majority of these infections resolves naturally but progress to precancerous lesions whenever there is persistence and delay in treatment. Majority of the cervical cancer cases, over 80% in sub-Saharan Africa including Ethiopia, have been detected at a late stage mainly due to poor early preventive measures. Therefore, utilization of early preventive measures could increase timely detection and treatment of precancerous changes and significantly reduce morbidity & mortality due to advanced disease.

Methods

In this interventional study we will randomly assign 16 clusters (kebeles) in to the intervention and the control arm using block randomization. The study will employ a cluster randomized controlled trial. Women are eligible to participate in this study when they satisfy certain eligibility criteria; being in the age range of 30–49 years, no history of hysterectomy, did not receive cervical cancer or pre-cancer treatment and non-pregnant. Home based couple education and counseling will be provided to the eligible participants within the intervention group, while the control group receives standard of care. Base line and end line surveys will be completed by interviewing 288 eligible women to evaluate the effect of couple education and counseling on the knowledge, attitude and cervical cancer screening uptake. Generally the intervention lasts for six months. The results of baseline & end line surveys will be compared between the groups to determine the effectiveness of the intervention. Blinding is not possible due to the clustering of the trial arms.

Discussion

Findings of the study will inform the regional or national scale up of the intervention modality to achieve the screening targets set by the Ethiopian government and world health organization.

Trial registration

PACTR, PACTR202108529472385. Registered on 05 August 2021, https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=16037
NTD-DR: Nonnegative tensor decomposition for drug repositioning
Authors: Jamali Ali Akbar , Tan Yuting , Kusalik Anthony , Wu Fang-Xiang
Published: July 2022

Computational drug repositioning aims to identify potential applications of existing drugs for the treatment of diseases for which they were not designed. This approach can considerably accelerate the traditional drug discovery process by decreasing the required time and costs of drug development. Tensor decomposition enables us to integrate multiple drug- and disease-related data to boost the performance of prediction. In this study, a nonnegative tensor decomposition for drug repositioning, NTD-DR, is proposed. In order to capture the hidden information in drug-target, drug-disease, and target-disease networks, NTD-DR uses these pairwise associations to construct a three-dimensional tensor representing drug-target-disease triplet associations and integrates them with similarity information of drugs, targets, and disease to make a prediction. We compare NTD-DR with recent state-of-the-art methods in terms of the area under the receiver operating characteristic (ROC) curve (AUC) and the area under the precision and recall curve (AUPR) and find that our method outperforms competing methods. Moreover, case studies with five diseases also confirm the reliability of predictions made by NTD-DR. Our proposed method identifies more known associations among the top 50 predictions than other methods. In addition, novel associations identified by NTD-DR are validated by literature analyses.
Mental health literacy of Internet gaming disorder and problematic smartphone use among Korean teenagers
Authors: Jeon Mina , Lee Mi-Sun , Yoon Ji-Young , Bhang Soo-Young
Published: July 2022

The last few decades have seen an increased interest in ‘Mental Health Literacy (MHL)’ which addresses knowledge and beliefs relating to mental health problems and is likely to hinder treatment-seeking behaviors. Although MHL research to date has explored various mental disorders, far too little attention has been paid to Internet Gaming Disorder (IGD) and Problematic Smartphone use (PSU). The objective of this study is to develop an MHL questionnaire for IGD and PSU by adopting the MHL approach in the previous literature and examine MHL of IGD and PSU in Korean teenagers by focusing on their ability to recognize addictions, and perceptions and help-seeking attitudes towards a person with addictions. The current study also aimed to compare Korean teenagers’ MHL depending on low- and high-risk of IGD and PSU. A total of 169 teenagers aged 10 and 16 years were recruited from schools and children’s centers in Seoul and completed the newly developed MHL questionnaire and screening questionnaires for IGD and PSU. The MHL questionnaire for IGD and PSU was designed as a vignette-based questionnaire that depicted behavioral characteristics of a severe problem with Internet and smartphone usage. Korean teenagers had a poor ability to recognize IGD and PSU and were more prone to seek parental help than professional help. The current study also showed that teenagers had better recognition of IGD than PSU and perceived that a person with IGD has a more difficult life than a person with PSU. Furthermore, a low-risk or high-risk group of IGD or PSU showed minimal differences in MHL. The current study provided empirical evidence to support a need to develop educational programs to improve Korean teenagers’ MHL for both IGD and PSU.
An empirical analysis of social public resources digital sharing system: Dissipative structure theory
Authors: Li Shengzhu , Jiang Fan
Published: July 2022

The development of the social public resource digital sharing system (SPRDSS) has been accelerated with the evolution of digital information and communication technologies (ICTs). This paper analyzes the dissipative structure features and formation process of SPRDSS in China. Combined with the Brusselator model and its transformation, this paper empirically analyzes the dissipative structure of SPRDSS using panel data collected from 30 Chinese provinces (excluding Tibet, Hong Kong, Macao, and Taiwan) from 2015 to 2019. The results show that the SPRDSS in China has pre-conditions to form a dissipative structure. At present, the SPRDSSs in most Chinese provinces have not yet formed the dissipative structure, but they are gradually evolving into it. The global orderliness of the sharing system is greater in eastern China than in central China and greater in central China than in western China. The potential for improving global orderliness is greater in western China than in central China and is greater in central China than in eastern China. Therefore, proper policies and measures should be adopted to accelerate the construction of SPRDSS based on the evolution of dissipative structure and to promote the sustainable development of the digital sharing economy.
Elevated alpha-fetoprotein in asymptomatic adults: Clinical features, outcome, and association with body composition
Authors: Jang Sangmi , Choi Gwang Hyeon , Chang Won , Jang Eun Sun , Kim Jin-Wook , Jeong Sook-Hyang
Published: July 2022

Background and aim

Apparently healthy individuals with elevated serum alpha-fetoprotein (AFP) levels (>7 ng/mL) for unknown causes visit clinics. We investigated their clinical characteristics, outcomes, and relationship with body fat deposition and muscle mass.

Methods

The case group included asymptomatic 137 individuals with “elevated AFP level” (R772) diagnostic code from 2009 to 2018 in a tertiary hospital. The control group enrolled 274 age- and sex-matched patients with <5 cm hepatic hemangiomas. Hepatic, visceral, and psoas muscle adiposity and psoas muscle index (PMI) were measured in the subgroups of 45 cases and 90 controls with pre-contrast computed tomography (CT) images.

Results

The case group (mean age 47.5 years, male 35.8%) showed higher AFP levels (10.3 vs 2.5 ng/mL, p<0.001) and total bilirubin (0.8 vs 0.7 mg/dL, p<0.001), but a lower body mass index (22.2 vs 23.3 kg/m2, p = 0.011) and alanine aminotransferase levels (17.0 vs 19.0 IU/L, p = 0.047) than the controls. During 13 months of median follow-up, there was no cancer or liver disease development. The AFP levels were stable. In the subgroups with CT images, cases showed a lower proportion of hepatic steatosis (4.4% vs 18.9%, p = 0.023), higher psoas muscle attenuation (48.2 vs 43.8 Hounsfield units, p<0.001) and higher PMI (5.7 vs 4.2 cm2/m2, p<0.001) than the controls.

Conclusion

Elevated AFP levels in asymptomatic individuals may play a role in expressing a protective phenotype against hepatic steatosis, myosteatosis, and sarcopenia. AFP levels in patients with elevated AFP were stable during follow-up without liver injury or cancer development. Interaction between AFP expression and steatosis warrants further study.
Physical activity and sitting time changes in response to the COVID-19 lockdown in England
Authors: Bailey Daniel P. , Wells Amy V. , Desai Terun , Sullivan Keith , Kass Lindsy
Published: July 2022

To reduce the spread of the novel coronavirus disease 2019 (COVID-19), national governments implemented measures to limit contact between citizens. This study evaluated changes in physical activity and sitting in response to the first COVID-19 lockdown in England and factors associated with these changes. A cross-sectional online survey-based study collected data from 818 adults between 29 April and 13 May 2020. Participants self-reported demographic information, physical activity and sitting for a ‘typical’ week before and during lockdown. Participants were grouped into low, moderate and high physical activity, and low and high (≥8 hours/day) sitting. Paired samples t-tests compared physical activity (MET-min/week) before and during lockdown. Pearson’s Chi-squared evaluated the proportion of participants in the physical activity and sitting categories. Logistic regression explored associations of demographic and behavioural factors with physical activity and sitting during lockdown. Walking and total physical activity significantly increased during lockdown by 241 (95% confidence interval [CI]: 176, 304) MET-min/week and 302 (CI: 155, 457) MET-min/week, respectively (P < 0.001). There was a 4% decrease in participants engaging in low physical activity and a 4% increase in those engaging in high physical activity from before to during lockdown (P < 0.001). The proportion engaging in high sitting increased from 29% to 41% during lockdown (P < 0.001). Lower education level (odds ratio [OR] = 1.65, P = 0.045) and higher BMI (OR = 1.05, P = 0.020) were associated with increased odds of low physical activity during lockdown, whereas non-White ethnicity (OR = 0.24, P = 0.001) was associated with reduced odds. Younger age was associated with increased odds of high sitting (OR = 2.28, P = 0.008). These findings suggest that physical activity and sitting both increased during lockdown. Demographic and behavioural factors associated with low physical activity and high sitting have been identified that could inform intervention strategies during situations of home confinement.
Adjuvant antimicrobial activity and resensitization efficacy of geraniol in combination with antibiotics on Acinetobacter baumannii clinical isolates
Authors: Kim Choon-Mee , Ko Young Jin , Lee Seul-Bi , Jang Sook Jin
Published: July 2022

Adjuvant use of geraniol, a plant essential oil component, is known to increase the efficacy of antibiotics by acting as a potent inhibitor of efflux mechanisms. In this study, we assessed the effect of a geraniol–antibiotic combination in 21 Acinetobacter baumannii clinical isolates consisting of high efflux (HE) and low efflux (LE) activity groups. We determined the MIC for geraniol and the four antibiotics and evaluated the adjuvant antimicrobial activity and resensitization efficacy of adjuvant geraniol. Geraniol–antibiotic combinations significantly reduced the MIC of all four antibiotics (P < 0.0001), and the fold change in MIC decreased by 4 to >256-fold for tigecycline, >16 to >4,096-fold for ceftazidime, 1 to >4,096-fold for cefepime, and >2 to >4096-fold for ciprofloxacin. Importantly, geraniol showed adjuvant antimicrobial activity and resensitization efficacy when used in combination with antibiotics in 21 A. baumannii clinical isolates. However, there was no statistically significant difference between the HE and LE groups. Low concentrations (0.125% and 0.0625%) of geraniol showed no cytotoxic or hemolytic activity. Our study shows that geraniol, acting as an antibiotic adjuvant, is a good candidate for in vivo studies of combination therapy for the treatment of MDR/XDR A. baumannii infections.
Development of freeway-based test scenarios for applying new car assessment program to automated vehicles
Authors: Ko Woori , Park Sangmin , Park Sungho , Jeong Harim , Yun Ilsoo
Published: July 2022

As automated driving technology continues to develop, studies are being conducted to develop various scenarios for assessing the functional safety, failure safety, and mobility of automated vehicles (AVs). As the commercialization of AVs progresses, it is necessary to develop a set of test scenarios for new car assessment programs (NCAPs), so as to provide information on the safety and reliability of AVs to consumers. To provide valuable information regarding newly emerged AVs to consumers who are willing to purchase them, it is necessary to derive specific and well-defined test scenarios based on the safety-in-use. Accordingly, to apply NCAPs to AVs, this study established test scenarios targeting freeways where AVs were expected to be commercialized. To this end, based on freeway traffic accident data and opinions of traffic safety and AV experts, we derived possible dangerous situations when an AV is maintaining a lane on a freeway. Functional scenarios were defined based on the derived dangerous situations. The priority of the defined functional scenarios was set using the analytic hierarchy process (AHP). Accordingly, this study presents a logical and concrete scenario construction methodology for deriving the ranges and values of test parameters for functional scenarios.
Increased fat mass index is associated with decreased glomerular filtration rate estimated from cystatin C. Data from Malmö Diet and Cancer cohort
Authors: Laucyte-Cibulskiene Agne , Nilsson Peter M. , Engström Gunnar , Christensson Anders
Published: July 2022

Background

This study aims to describe associations of obesity and CKD in a Swedish urban population. The impact of fat mass, from bioimpedance analysis, on eGFR based on cystatin C and/or creatinine is studied.

Methods

5049 participants from Malmö Diet and Cancer Study the cardiovascular arm (MDCS‐CV) with available body mass composition (single frequency bioimpedance analysis) and cystatin C measured at baseline were selected. Body mass index (kg/m2) was used to define overweight/obesity. eGFR was calculated using cystatin C (eGFRCYS) and creatinine (eGFRCR) equations: Chronic Kidney Disease Epidemiology Collaboration 2012 (CKD-EPICR, CKD-EPICYS, CKD-EPICR-CYS), eGFRCYS based on Caucasian, Asian, pediatric, and adult cohorts (CAPA), the Lund-Malmö revised equation (LMrev), and Modified Full Age Spectrum creatinine-based equation (EKFCCR). Two different fat mass index (FMI) z-scores were calculated: FMI z-scoreLarsson and FMI z-scoreLee.

Results

Lower eGFRCYS and eGFRCR-CYS following multiple adjustments were prevalent in overweight/obese subjects. Increase in FMI z-scoreLarsson or FMI z-scoreLee was related to decrease in predicted CAPA, CKD-EPICYS, CKD-EPICR-CYS and CAPA-LMrev equation.

Conclusion

eGFRCYS, in contrast to combined eGFRCR-CYS and eGFRCR, demonstrate the strongest association between FMI and kidney function.
Mobilization of multilineage-differentiating stress-enduring cells into the peripheral blood in liver surgery
Authors: Kikuchi Koji , Katagiri Hirokatsu , Suzuki Yuji , Nitta Hiroyuki , Sasaki Akira
Published: July 2022

Purpose

This study investigated whether liver damage severity relates to the mobilization of multilineage-differentiating stress-enduring (Muse) cells, which are endogenous reparative pluripotent stem cells, into the peripheral blood (PB) and whether the degree of mobilization relates to the recovery of liver volume following human liver surgery.

Methods

Forty-seven patients who underwent liver surgery were included in the present study. PB-Muse cells were counted before surgery, on postoperative days (PODs) 3 and on POD 7. Liver volume was measured using computed tomography before and after surgery.

Results

The PB-Muse cell count increased after surgery. The number of PB-Muse cells before surgery was higher, but without statistical significance in the group with neoplasms than in the healthy group that included liver donors (p = 0.065). Forty-seven patients who underwent liver surgery were divided into major hepatic resection (MHR; hepatectomy of three or more segments according to the Couinaud classification, n = 22) and minor hepatic resection (mhr; hepatectomy of two segments or less according to the Couinaud classification, n = 25) groups. PB-Muse cells increased at high rates among MHR patients (p = 0.033). Except for complication cases, PB-Muse cells increased at higher rates in the group with advanced liver volume recovery (p = 0.043). The predictive impact of the rate of increase in PB-Muse cells on the recovery of liver volume was demonstrated by multivariate analysis (OR 11.0, p = 0.014).

Conclusions

PB-Muse cell mobilization correlated with the volume of liver resection, suggesting that the PB-Muse cell number reflects the degree of liver injury. Given that the degree of PB-Muse cell mobilization was related to liver volume recovery, PB-Muse cells were suggested to contribute to liver regeneration, although this mechanism remains unclear.