bluuebunny/crossref_metadata_2025 huggingface dataset:
Echocardiographic assessment of left ventricular volumes: a comparison of different methods in athletes
Authors: Kandels Joscha , Denk Verena , Pedersen Maria Weinkouff , Kragholm Kristian Hay , Søgaard Peter , Tayal Bhupendar , Marshall Robert Percy , Denecke Timm , Lindgren Filip Lyng , Hagendorff Andreas , Stöbe Stephan
Published: August 2024

Background

Cardiac magnetic resonance imaging (cMRI) is considered the gold standard for the assessment of left ventricular (LV) systolic function. However, discrepancies have been reported in the literature between LV volumes assessed by transthoracic echocardiography (TTE) and cMRI. The objective of this study was to analyze the differences in LV volumes between different echocardiographic techniques and cMRI.

Methods and results

In 64 male athletes (21.1 ± 4.9 years), LV volumes were measured by TTE using the following methods: Doppler echocardiography, anatomical M-Mode, biplane/triplane planimetry and 3D volumetry. In addition, LV end-diastolic (LVEDV), end-systolic (LVESV), and stroke volumes (LVSV) were assessed in 11 athletes by both TTE and cMRI. There was no significant difference between LVEDV and LVESV determined by biplane/triplane planimetry and 3D volumetry. LVEDV and LVESV measured by M-Mode were significantly lower compared to 3D volumetry. LVSV determined by Doppler with 3D planimetry of LV outflow tract was significantly higher than 2D planimetry and 3D volumetry, whereas none of the planimetric or volumetric methods for determining LVSV differed significantly. There were no significant differences for LVEDV, LVESV, LVSV and LVEF between cMRI and TTE determined by biplane planimetry in the subgroup of 11 athletes.

Conclusion

The choice of echocardiographic method used has an impact on LVSV in athletes, so the LVSV should always be checked for plausibility. The same echocardiographic method should be used to assess LVSV at follow-ups to ensure good comparability. The data suggest that biplane LV planimetry by TTE is not inferior to cMRI.
Analytical and clinical evaluation of a novel real-time PCR-based detection kit for Mpox virus
Authors: Bunse Till , Ziel Anne , Hagen Philipp , Rigopoulos George , Yasar Umit , Inan Hakan , Köse Gurbet , Eigner Ulrich , Kaiser Rolf , Bardeck Nils , Köffer Jasmin , Kolb Melissa , Ren Xiaomei , Tan Deyong , Dai Lizhong , Protzer Ulrike , Wettengel Jochen M.
Published: August 2024

Outbreaks of emerging diseases, like Mpox in 2022, pose unprecedented challenges to global healthcare systems. Although Mpox cases globally decreased since the end of 2022, numbers are still significant in the African Region, European Region, Region of the Americas, and Western Pacific Region. Rapid and efficient detection of infected individuals by precise screening assays is crucial for successful containment. In these assays, analytical and clinical performance must be assessed to ensure high quality. However, clinical studies evaluating Mpox virus (MPXV) detection kits using patient-derived samples are scarce. This study evaluated the analytical and clinical performance of a new diagnostic MPXV real-time PCR detection kit (Sansure Monkeypox Virus Nucleic Acid Diagnostic Kit) using patient-derived samples collected in Germany during the MPXV clade IIb outbreak in 2022. Our experimental approach determined the Limit of Detection (LoD) to less than 200 cp/mL using whole blood samples and samples derived from vesicles or pustules. Furthermore, we tested potentially inhibiting substances and pathogens with homologous nucleic acid sequences or similar clinical presentation and detected no cross-reactivity or interference. Following this, the assay was compared to a CE-marked test in a clinical performance study and achieved a diagnostic sensitivity of 100.00% and diagnostic specificity of 96.97%. In summary, the investigated real-time PCR assay demonstrates high analytical performance and concurs with the competitor device with high specificity and sensitivity.
The influence of air masses on human mortality in the contiguous United States
Authors: Lee Cameron C. , Silva Alindomar , Ibebuchi Chibuike , Sheridan Scott C.
Published: August 2024

Temperature-related mortality is the leading cause of weather-related deaths in the United States. Herein, we explore the effect of air masses (AMs) – a relatively novel and holistic measure of environmental conditions – on human mortality across 61 cities in the United States. Geographic and seasonal differences in the effects of each AM on deseasonalized and detrended anomalous lagged mortality are examined using simple descriptive statistics, one-way analyses of variance, relative risks of excess mortality, and regression-based artificial neural network (ANN) models. Results show that AMs are significantly related to anomalous mortality in most US cities, and in most seasons. Of note, two of the three cool AMs (Cool and Dry-Cool) each show a strong, but delayed mortality response in all seasons, with peak mortality 2 to 4 days after they occur, with the Dry-Cool AM having nearly a 15% increased risk of excess mortality. Humid-Warm (HW) air masses are associated with increases in deaths in all seasons 0 to 1 days after they occur. In most seasons, these near-term mortality increases are offset by reduced mortality for 1–2 weeks afterwards; however, in summer, no such reduction is noted. The Warm and Dry-Warm AMs show slightly longer periods of increased mortality, albeit slightly less intensely as compared with HW, but with a similar lag structure by season. Meanwhile, the most seasonally consistent results are with transitional weather, whereby passing cold fronts are associated with a significant decrease in mortality 1 day after they occur, while warm fronts are associated with significant increases in mortality at that same lag time. Finally, ANN modeling reveals that AM-mortality relationships gleaned from a combined meta-analysis can actually lead to more skillful modeling of these relationships than models trained on some individual cities, especially in the cities where such relationships might be masked due to low average daily mortality.
Daily sunshine grids for Austria since 1961 – combining station and satellite observations for a multi-decadal climate-monitoring dataset
Authors: Hiebl Johann , Bourgeois Quentin , Tilg Anna-Maria , Frei Christoph
Published: August 2024

Grid datasets of sunshine duration at high spatial resolution and extending over many decades are required for quantitative applications in regional climatology and environmental change (e.g., modelling of droughts and snow/ice covers, evaluation of clouds in numerical models, mapping of solar energy potentials). We present a new gridded dataset of relative (and derived absolute) sunshine duration for Austria at a grid spacing of 1 km, extending back until 1961 at daily time resolution. Challenges in the dataset construction were consistency issues in the available station data, the scarcity of long time series, and the high variation of cloudiness in the study region. The challenges were addressed by special efforts to correct evident breaks in the station series and by adopting an analysis method, which combines station data with satellite data. The methodology merges the data sources non-contemporaneously, using statistical patterns distilled over a short period, which allowed involving satellite data even for the early part of the study period. The resulting fields contain plausible mesoscale structures, which could not be resolved by the station network alone. On average, the analyses explain 47% of the spatial variance in daily sunshine duration at the stations. Evaluation revealed a slight systematic underestimation (− 1.5%) and a mean absolute error of 9.2%. The average error is larger during winter, at high altitudes, and around the 1990s. The dataset exhibits a conditional bias, which can lead to considerable systematic errors (up to 15%) when calculating sunshine-related climate indices.
Heatmap-Based Active Shape Model for Landmark Detection in Lumbar X-ray Images
Authors: Choi Minho , Jang Jun-Su
Published: August 2024

Medical staff inspect lumbar X-ray images to diagnose lumbar spine diseases, and the analysis process is currently automated using deep-learning techniques. The detection of landmarks is necessary in the automatic process of localizing the position and identifying the morphological features of the vertebrae. However, detection errors may occur owing to the noise and ambiguity of images, as well as individual variations in the shape of the lumbar vertebrae. This study proposes a method to improve the robustness of landmark detection results. This method assumes that landmarks are detected by a convolutional neural network-based two-step model consisting of Pose-Net and M-Net. The model generates a heatmap response to indicate the probable landmark positions. The proposed method then corrects the landmark positions using the heatmap response and active shape model, which employs statistical information on the landmark distribution. Experiments were conducted using 3600 lumbar X-ray images, and the results showed that the landmark detection error was reduced by the proposed method. The average value of maximum errors decreased by 5.58% after applying the proposed method, which combines the outstanding image analysis capabilities of deep learning with statistical shape constraints on landmark distribution. The proposed method could also be easily integrated with other techniques to increase the robustness of landmark detection results such as CoordConv layers and non-directional part affinity field. This resulted in a further enhancement in the landmark detection performance. These advantages can improve the reliability of automatic systems used to inspect lumbar X-ray images. This will benefit both patients and medical staff by reducing medical expenses and increasing diagnostic efficiency.
Rural Suicide: Demographics, Causes, and Treatment Implications
Authors: Prazak Michael , Bacigalupi Rachel , Hamilton Stephen C.
Published: August 2024

Suicide rates in rural areas are higher than urban areas and growing, with current treatment developments only exacerbating this discrepancy. Within individual factors, both age and gender relate to and intersect with personal values related to self-reliance and attitudes toward mental health difficulties and treatment to increase suicide risk. The lethality ubiquitous in rural environments and occupations is a leading factor in rural suicide rates, with other factors such as race alternately noted to be a key factor but with more mixed findings. The cultural values of rural communities as typically negative toward mental health disclosure and treatment contribute to the disengagement of rural communities from treatment that may otherwise prevent suicides, exacerbating the physical lack of treatment access many rural communities experience. Working within the primary care system alongside increased telehealth utilization are suggested to reduce rural suicide rates.
“In God We Trust”: An Exploratory Study of the Associations Between Religiosity and the Caregiving Experiences of Parents of Children with Rare Diseases in Poland
Authors: Domaradzki Jan , Walkowiak Dariusz
Published: August 2024

Most children with a rare disease are cared for by their family members but parenting such a child is extremely demanding due to the complexity and severity of symptoms, with serious physical, emotional, social, and financial consequences for caregivers. Although religion may serve as a positive coping strategy, little is known about its role in helping caregivers manage the stress related to the burden of caregiving in Poland. Therefore, we surveyed 925 Polish family caregivers of children with rare diseases to understand the association between caregivers’ religiosity and their caring experiences. The findings suggest that parents’ religiosity is associated with a more positive caregiving experience, perceived quality of life, and experienced caregiving burden. While religious caregivers reported experiencing less distressing emotions and stressed the encouraging impact of their child’s disease on their life more often, non-religious caregivers experienced role captivity and role overload more frequently. Since religion may serve as a source of strength and a protecting factor against mental health problems and the burden of caregiving, healthcare professionals should be aware of the importance of religious and spiritual care, and caregivers’ religiosity should be considered an integral part of a holistic approach.
Persuasion and gender: experimental evidence from two political campaigns
Authors: Galasso Vincenzo , Nannicini Tommaso
Published: August 2024

We investigate differential responses by gender to competitive persuasion in political campaigns. We implemented a survey and a field experiment during two mayoral elections in Italy. Eligible voters were exposed to a positive or negative campaign by an opponent. The survey experiment used on-line videos and slogans. The field experiment used door-to-door canvassing. In both experiments, gender differences emerge. Females vote more for the opponent and less for the incumbent when exposed to positive—as opposed to negative—campaigning. Males do the opposite. These differences cannot be explained by gender identification, ideology, or other voters’ observable attributes.
A Quantitative Method to Measure Oil-Separation Properties of Lubricating Greases
Authors: Hogenberk Femke , van den Ende Dirk , de Rooij Matthijn B. , Lugt Piet M.
Published: August 2024

The oil-separation properties of lubricating greases are responsible for transporting base oil to the bearing contacts. Therefore, a good understanding of these properties is necessary to predict grease life based on physical grease properties. Currently, oil separation for small, aged grease samples collected from bearings, is studied using so-called maintenance tools. These tools give qualitative insight into the grease properties, e.g., increases or decreases in oil separation after ageing of the grease. In this work, a quantitative, lab-scale method to study oil separation is presented. Using this method, the amount of base oil transferred from a grease sample to a piece of blotting paper is measured based on the difference in light transmission through the oil stain and the dry paper. Translation of transmitted light intensity to oil concentration is accomplished using a modified Lambert-Beer’s law. This enables the determination of the instantaneous bleed rate and oil content. In combination with a physical model, this method can help to improve the understanding of the driving forces behind oil separation, e.g., the affinity pressure and permeability.
Beat-to-beat blood pressure variability, hippocampal atrophy, and memory impairment in older adults
Authors: Lohman Trevor , Sible Isabel , Engstrom Allison C. , Kapoor Arunima , Shenasa Fatemah , Head Elizabeth , Sordo Lorena , Alitin John Paul M. , Gaubert Aimee , Nguyen Amy , Rodgers Kathleen E. , Bradford David , Nation Daniel A.
Published: August 2024

Visit-to-visit blood pressure variability (BPV) predicts age-related hippocampal atrophy, neurodegeneration, and memory decline in older adults. Beat-to-beat BPV may represent a more reliable and efficient tool for prospective risk assessment, but it is unknown whether beat-to-beat BPV is similarly associated with hippocampal neurodegeneration, or with plasma markers of neuroaxonal/neuroglial injury. Independently living older adults without a history of dementia, stroke, or other major neurological disorders were recruited from the community (N = 104; age = 69.5 ± 6.7 (range 55–89); 63% female). Participants underwent continuous blood pressure monitoring, brain MRI, venipuncture, and cognitive testing over two visits. Hippocampal volumes, plasma neurofilament light, and glial fibrillary acidic protein levels were assessed. Beat-to-beat BPV was quantified as systolic blood pressure average real variability during 7-min of supine continuous blood pressure monitoring. The cross-sectional relationship between beat-to-beat BPV and hippocampal volumes, cognitive domain measures, and plasma biomarkers was assessed using multiple linear regression with adjustment for demographic covariates, vascular risk factors, and average systolic blood pressure. Elevated beat-to-beat BPV was associated with decreased left hippocampal volume (P = .008), increased plasma concentration of glial fibrillary acidic protein (P = .006), and decreased memory composite score (P = .02), independent of age, sex, average systolic blood pressure, total intracranial volume, and vascular risk factor burden. In summary, beat-to-beat BPV is independently associated with decreased left hippocampal volume, increased neuroglial injury, and worse memory ability. Findings are consistent with prior studies examining visit-to-visit BPV and suggest beat-to-beat BPV may be a useful marker of hemodynamic brain injury in older adults.
Investigation of Chemical Composition, Antioxidant Properties, and Molecular Docking in Different Roasting Stages of Coffee Beans
Authors: Aytar Erdi Can , Aydın Betül
Published: August 2024

This study investigates the chemical composition and antioxidant properties of coffee beans at different roasting stages, namely green coffee, filter-roasted coffee, and espresso-roasted coffee. Using a Golden Roaster machine, specific roasting profiles were developed to achieve distinct flavor characteristics: an intense flavor and balanced acidity for espresso, and a balanced, complex taste for filter coffee. Results indicate that filter-roasted coffee exhibits the highest radical scavenging activity, as evidenced by its lowest IC50 value for 2,2-diphenyl-1-picrylhydrazyl (DPPH) inhibition. Green coffee demonstrates superior iron chelation activity, while filter-roasted coffee contains the highest flavonol content and espresso-roasted coffee has the highest flavonoid content. Bacterial sensitivity tests show that both filter-roasted and espresso-roasted coffee are effective against certain strains, including Klebsiella pneumoniae ATCC 13883. Gas chromatography-mass spectrometry (GC–MS) analysis identifies key compounds such as caffeine and 4,4-dimethyl-3-(3-methylbut-3-enylidene)-2-methylenebicyclo [4.1.0] heptane in filter-roasted coffee, and 2-(2-hydroxyphenyl) buta-1,3-diene in espresso-roasted coffee. Molecular docking and in silico molecule’s absorption, distribution, metabolism, excretion, and toxicity (ADME) studies suggest potential pharmaceutical applications for coffee compounds. These findings provide valuable insights into coffee’s complex chemistry and its health-related properties. Additionally, the importance of coffee profiling in bioprocesses is highlighted by the need to carefully analyze the profiling process to optimize the biological effects and health benefits of these compounds. Coffee profiling not only enhances consumer taste experiences but also contributes to a better understanding of coffee’s potential health benefits by effectively identifying biomolecules and nutrients for use in bioprocesses.

Graphical Abstract
In vitro models of the choroid plexus and the blood-cerebrospinal fluid barrier: advances, applications, and perspectives
Authors: Schwerk Christian , Schroten Horst
Published: August 2024

The choroid plexus (CP), a highly vascularized endothelial–epithelial convolute, is placed in the ventricular system of the brain and produces a large part of the cerebrospinal fluid (CSF). Additionally, the CP is the location of a blood–CSF barrier (BCSFB) that separates the CSF from the blood stream in the CP endothelium. In vitro models of the CP and the BCSFB are of high importance to investigate the biological functions of the CP and the BCSFB. Since the CP is involved in several serious diseases, these in vitro models promise help in researching the processes contributing to the diseases and during the development of treatment options. In this review, we provide an overview on the available models and the advances that have been made toward more sophisticated and “in vivo near” systems as organoids and microfluidic lab-on-a-chip approaches. We go into the applications and research objectives for which the various modeling systems can be used and discuss the possible future prospects and perspectives.
The Effect of School Principals’ Empowering Leadership Behaviors on Well-Being at Work: The Mediating Role of Organizational Ostracism
Authors: Okçu Veysel , Cemaloğlu Necati , Ay İnan
Published: August 2024

This study investigates the impact of empowering leadership exhibited by school principals on teachers’ perspectives on organizational ostracism and well-being at work in educational settings in Türkiye. Applying a cross-sectional research design, we collected responses from 603 teachers in different provinces. The results reveal that empowering leadership has a positive impact on teachers’ well-being. Furthermore, empowering leadership practices significantly diminish teachers’ perceptions of ostracism, thus cultivating a positive and inclusive work environment. Our findings emphasize the pivotal role of organizational ostracism in mediating the relationship between empowering leadership and well-being at work, highlighting the importance of empowering leadership in creating a healthy and supportive school setting. These insights offer valuable guidance to school leaders, teachers, and policymakers in crafting conducive work environments, enhancing teacher–principal relationships, and promoting overall teacher well-being.
Lubrication performance of graphene in the sliding electrical contact interface
Authors: Wang Lv , Tang Qian , Liang Tao , Liu Chenxu , Sun Deen , Wang Shu , Li Jingchuan , Zhang Sam , Meng Yonggang , Huang Yuehua
Published: August 2024

Electrical contact materials are increasingly widely used, but the existing electric contact lubricants still have lots of room for improvement, such as anti-wear performance and lubrication life. Due to the excellent electrical and lubrication properties, graphene shows great potential in lubricating the sliding electrical contact interface, but there is a lack of relevant research. Some researchers have studied the lubrication performance of graphene between the gold-coated/TiN-coated friction pair at an ultra-low current. However, the lubrication performance of graphene on more widely used electrical contact materials such as copper and its alloys under larger and more commonly used current or voltage conditions has not been reported. In this paper, we study the lubrication performance of graphene in the copper and its alloys sliding electrical contact interface under usual parameters, which is explored through four aspects: different substrates—copper and brass, different test methods—constant voltage and constant current, different normal loads and durability test. The experiments demonstrate that graphene can significantly reduce the friction and wear on brass and copper under the above test methods and parameters, with low contact resistance at the same time. Our work is expected to provide a new lubricant for electrical contact materials and contribute to enriching the tribological theory of graphene.
Activating Fenton-like reaction by hydrochars containing persistent free radicals derived from various pomelo peel components
Authors: Zhang Chaoyang , Jiang Zili , Sun Wanxue , Tang Yuyuan , Zhang Zhanying , Shi Changrong , Ruan Xiuxiu
Published: August 2024

To reveal the influence of the diversity of precursors on the formation of environmental persistent free radicals (EPFRs), pomelo peel (PP) and its physically divided portion, pomelo cuticle (PC), and white fiber (WF) were used as precursors to prepare six hydrochars: PPH-Fe, PCH-Fe, WFH-Fe, PPH, PCH, and WFH with and without Fe(III) addition during hydrothermal carbonization (HTC). PPH-Fe and WFH-Fe had higher EPFRs content (9.11 × 1018 and 8.25 × 1018 spins·g−1) compared to PPH and WFH (3.33 × 1018 and 2.96 × 1018 spins·g−1), indicating that iron-doping favored EPFRs formation. However, PCH-Fe had lower EPFRs content (2.78 × 1018 spins·g−1) than PCH (7.95 × 1018 spins·g−1), possibly due to excessive iron leading to the consumption of the generated EPFRs. For another reason, the required Fe(III) amount for EPFRs formation might vary among different precursors. PC has a lower concentration of phenolic compounds but 68–97% fatty acids, while WF and PP are rich in cellulose and lignin. In the Fenton-like reaction, oxygen-centered radicals of hydrochar played a significant role in activating H2O2 and efficiently degrading bisphenol A (BPA). Mechanisms of reactive oxygen species (ROS) generation in hydrochar/H2O2 system were proposed. EPFRs on hydrochar activate H2O2 via electron transfer, creating ·OH and 1O2, leading to BPA degradation. More importantly, the embedded EPFRs on the hydrochar's inner surface contributed to the prolonged Fenton-like reactivity of PPH-Fe stored for 45 days. This study demonstrates that by optimizing precursor selection and iron doping, hydrochars can be engineered to maximize their EPFRs content and reactivity, providing a cost-effective solution for the degradation of hazardous pollutants.

Graphical abstract
Effect of Na2SiO3/NaOH rate and natural zeolite content on basalt fiber reinforced eco-efficient slag-based geopolymer mortar synthesis
Authors: Efe Murat , Öz Ali , Bayrak Barış , Kaplan Gökhan , Aydın Abdulkadir Cüneyt
Published: August 2024

Considering that industrial wastes such as granulated blast furnace slag (GBFS) and fly ash (FA) will be released less or more in the future, developing geopolymer composites with natural pozzolans is a critical issue today. In this study, geopolymer composites with different SS (sodium silicate)/SH (sodium hydroxide) rates (2.0, 2.5 and 3.0) were produced by NZ reinforcement at 5%, 10% and 15%, and their physicomechanical, transport, high-temperature resistance, microstructure, carbon footprint and cost features were investigated. Geopolymer composites had been heat-cured for 8 h at 80 °C. The porosity of geopolymer composites varies between 5.2 and 7.2%, while their water absorption is between 3.4 and 6.9%. The dry unit weight of all geopolymer composites is less than 2300 kg/m3. The compressive strength of the geopolymer composite with an SS/SH rate of 3 and an NZ rate of 5% was about 75 MPa, and the compressive strength of the geopolymer composite with an SS/SH rate of 2 and an NZ rate of 15% was about 40 MPa. The capillary water absorption value of geopolymer composites is generally less than 1 kg/m2. While the compressive strength of geopolymer composites exposed to 600 °C ranged from 21.2 to 40.5 MPa, using 5% and 10% NZ generally improved the high-temperature resistance. The carbon emission of geopolymer composites was between 391.4 and 400.8 kgCO2/kg, while the cost increased only slightly with increasing NZ content. As a result, NZ content of 10% when the SS/SH rate is 2.5 and NZ content of 5% when the SS/SH rate is 3 improves many features of geopolymer composites.
Optimized Technique for College Students Job Searching Strategies Using Fuzzy Logic Control with Cuckoo Search Algorithm
Authors: Xiao Youping , Liu Fei
Published: August 2024

College students face uncertainties during job searches due to a lack of career planning, unclear objectives, and ineffective search strategies, leading to poor employment outcomes. Fuzzy Control (FC) based Job Search Strategies (JS2) are proposed in this research as an optimized technique named FC-JS2-TSC. This technique combines Takagi-Sugeno (TS) fuzzy inference with Cuckoo (C) search optimization. The primary goals are improving individualized advice and creating an integrated system to deal with job search concerns. The FC uses fuzzy logic and sets to model uncertainties such as vague job desires and ever-changing market circumstances. Individual student profiles and preferences are used to fine-tune methods by cuckoo search. Through experimental validation, we can see that FC-JS2-TSC outperforms previous methods in terms of both job strategy selection and results. As a measure of system efficacy, the results demonstrate a high Cronbach's alpha reliability of 0.96, a low RMSEA of 0.04 and 96.6% regarding job offers. By adjusting tactics in response to uncertainty, the innovative FC-JS2-TSC algorithm facilitates data-driven, personalized decision-making, ultimately leading to more efficient job searches. It has an integrated design that combines optimization with fuzzy logic's uncertainty handling to ensure students have the best possible chance of success in their job searches.
Reflection: Moral Firms and the Future of Capitalism
Authors: Henderson Rebecca M.
Published: August 2024

Capitalism has taken many forms over the last 500 years. This short essay asks whether rediscovering the idea that corporations have a moral duty to contribute to the social good might help create a form of capitalism capable of addressing the massive problems that we face. I argue that the property view of the corporation, or the idea that the sole goal of the corporation should be to maximize investor returns, might once have been appropriate, but is currently causing enormous damage. I suggest that the entity view of the corporation, or the view that the primary purpose of the corporation is to serve the common good, has a long history, and is currently remerging in ways that have the potential to help reform capitalism in powerful ways.
Radical Mercantilism and Fascist Italy’s East African Empire
Authors: Turtur Noelle
Published: August 2024

This article traces the evolution of Italian strategies for imperial expansion from the decades after unification—when many came to believe that imperial conquest would more advantageously position Italy in the liberal capitalist global economy—to the height of the fascist colonial project in the Horn of Africa—when the fascists tried to break with the liberal global economy and construct a new, radical mercantilist and corporatist empire. Taking inspiration from their predecessors, the fascist regime extracted capital, resources, and labor from Africans and Italians to finance its war against the Ethiopian empire and its colonization of the Horn. While the war temporarily stimulated Italian industry, employed hundreds of thousands of work-hungry Italians, and consolidated the regime’s many corporatist institutions, it drained Italy’s reserves and alarmed the Duce’s allies among Italy’s industrial and financial elite. The regime, thus, shifted strategies, focusing on reducing the cost of the empire by exploiting African workers, eliminating inefficient small enterprises, and creating vast concessions for Italian industrialists. Conquering new territories and markets, acquiring a variety of primary resources, and empowering industry, Mussolini and the radical mercantilist-corporatists aimed to resolve Italy’s perceived under-development, by placing Italy at the center of a great fascist Eurafrican empire that could dictate the terms of its engagement with the rest of the world.
A Reappraisal of Albert Aftalion’s Theory of Structural Transformation in an Era of Decarbonization
Authors: Coffman D'Maris , Scazzieri Roberto
Published: August 2024

Decarbonization is a momentous challenge for capitalism and makes one ask which changes in its morphology may be necessary to achieve that objective. The contribution by the French economist Albert Aftalion (1874–1956), with its emphasis on intermediate levels of aggregation (the “meso“ approach), the differentiated time profiles of economic actoivities, and their differential speeds of reaction to dynamic impulses, provides an invaluable heuristic for conceptualizing the structural transformations required by transition to a low energy regime. Aftalion’s analysis of industrial capitalism emphasizes that structural changes occur along multiple co-existing time horizons. This provides tools to analyze the time constraints on the sequencing of structural changes for different sectors on a decarbonization trajectory without neglecting the strict time requirements for implementing effective climate change mitigation. This interplay of time horizons is central to decarbonization, and it will require a new balance between the invisible hand of markets and the visible hand of states and other public bodies. Moreover, Aftalion’s emphasis on material constraints offers a novel approach to conceptualizing the importance of intermediate levels of aggregation in economic theory, thereby offering a new basis for sectoral policymaking and a fundamental challenge to institutionalist accounts of the morphology of capitalism.
The Bend on the Haiyuan Strike‐Slip Fault Leads to Segmented Activity of the Minle‐Damaying Thrust Fault in the Qilian Shan, the Northeastern Tibetan Plateau
Authors: Liu Qingri , Xiong Jianguo , Zhang Peizhen , Tao Wei , Huang Luyuan , Yang Xuhang , Zhang Yihui , Huang Feipeng , Zhang Xiuli , Zhang Huiping , Li Chuanyou , Li Youli
Published: August 2024

The present tectonic regime of the Qilian Shan is dominated by large northeast and northwest striking strike‐slip faults and northwest striking thrust faults. Deformation distribution between the subparallel Haiyuan Strike‐slip Fault and the Minle‐Damaying Thrust Fault (MDF) is crucial for understanding the orogenic mechanism of the northeastern Tibetan Plateau. However, the uncertain kinematics of the MDF and the stress variation along the strike‐varying Haiyuan Fault inhibit further discussion of their relationship. Five key sites along the MDF were selected for analysis of terrace abandonment ages and vertical offsets to determine the slip rates. Two finite element models were constructed to calculate the stress‐strain relationship between the Haiyuan Fault and MDF. We find that the activity of the MDF can be divided into two segments by a stepover with less activity and lower terrain at the Xida River site. Shortening rates of the MDF vary between 0.2 and 2.4 mm/a since the late Pleistocene with trapezoidal trends on both fault segments. The two finite element models and GPS data reveal that the strain rates are lower at the Xida River site but higher at the Menyuan Bend on the Haiyuan Fault. We infer that long‐term strain accumulation at the Menyuan Bend may have mitigated the tectonic activity northeast to the bend under the northeastward stress field, including the activity of the MDF at the Xida River site, and resulted in the segmentation of the MDF.
Aerosol‐Calibrated Matched Filter Method for Retrievals of Methane Point Source Emissions Over the Los Angeles Basin
Authors: Feng Chenxi , Chen Sihe , Zeng Zhao‐Cheng , Luo Yangcheng , Natraj Vijay , Yung Yuk L.
Published: August 2024

Methane, with a global warming potential roughly 86 times greater than carbon dioxide over a 20‐year timeframe, plays a crucial role in global warming. Remote sensing retrieval is a pivotal methodology for identifying methane emission sources, with accuracy influenced largely by surface and atmospheric properties, including aerosols. In this study, we propose an Aerosol‐Calibrated Matched Filter (ACMF) algorithm to improve the traditional Matched Filter (MF) method. Our new approach incorporates an aerosol scattering correction factor to reduce the aerosol‐induced bias on methane retrievals. Validating our algorithm through simulated spectra, we demonstrate that considering the aerosol scattering effect significantly reduces retrieval errors compared to MF methods by an average of approximately 90%. We apply our newly developed algorithm to hyperspectral data obtained from the Airborne Visible/Infrared Imaging Spectrometer—Next Generation in the Los Angeles Basin and focus on 11 plumes identified through case studies. Our results reveal that ACMF estimates of emission rates and inversion uncertainties exhibit an average reduction of approximately 4% compared to corresponding MF results, with deviation increasing with aerosol optical depth (AOD).
Lunar Lava Tube Revealed Beneath Collapsed Pit
Authors: Cartier Kimberly
Published: August 2024

The Sea of Tranquility is home to at least one lunar lava tube, which could preserve a pristine and unweathered record of lunar volcanism.
Unveiling the Transition From Paleolake Lisan to Dead Sea Through the Analysis of Lake Paleoshorelines and Radiometric Dating of Fossil Stromatolites
Authors: Jara‐Muñoz Julius , Agnon Amotz , Fohlmeister Jens , Tomás Sara , Mey Jürgen , Frank Norbert , Schröder Birgit , Schröder‐Ritzrau Andrea , Garcin Yannick , Darvasi Yaniv , Melnick Daniel , Mutti Maria , Strecker Manfred R.
Published: August 2024

To date, the most complete paleolake‐level reconstructions for the late Pleistocene water bodies that once occupied the Dead Sea depression have been based on the combination of dating of lake sediments and terrestrial materials. However, despite these major accomplishments, there is still limited spatial control regarding the water levels, suggesting some degree of uncertainty concerning the magnitude and rate of lake‐level changes. Here, we re‐examine the late Pleistocene lake‐level changes in the Dead Sea during the transition from paleolake Lisan to the present‐day Dead Sea. We rely on systematic dating of fossil stromatolites including 84 radiocarbon and 15 U‐series ages, stable‐isotope measurements, paleobiology, high‐resolution topography, and numerical modeling to assess lake‐level changes. Our results indicate that the highstand of paleolake Lisan was of shorter duration and the transition between Lake Lisan and the Dead Sea occurred at least 5 Kyrs earlier than previously indicated. By refining the timeline and accuracy of lake‐level positions during the transition paleolake Lisan—Dead Sea, our study offers new insights into the regional and local paleo‐climatic conditions during the last glacial period in this region.
Unloading Uplift Caused by Surface Processes in New Zealand's Southern Alps
Authors: Liu Shaozhuo , Moulin Adrien , Jónsson Sigurjón
Published: August 2024

The Southern Alps experiences rapid bedrock uplift and intense surface processes like erosion and deglaciation. We quantify how the erosion and deglaciation contribute to the ongoing vertical motions using geophysical models. The erosional unloading uplift is found to be 0.5–1.5 mm/yr throughout the central Southern Alps, whereas the recent deglaciation may locally produce uplift up to 1–3 mm/yr. The estimated unloading uplift accounts for 10%–40% of the GNSS‐observed uplift. After correcting the unloading uplift, the GNSS‐observed uplift can be explained by about 4–6 mm/yr dip‐slip motion on the Alpine fault, which is 10%–50% below previous geodetic estimates. Hence, unloading uplift must be evaluated when interpreting geodetic observations in tectonically active mountain ranges subjected to intense surface processes.
Basaltic Pulses and Lithospheric Thinning—Plio‐Pleistocene Magmatism and Rifting in the Turkana Depression (East African Rift System)
Authors: Cancel Vazquez Sahira M. , Rooney Tyrone O. , Brown Eric L. , Bollinger Andrew , Bastow Ian D. , Steiner R. Alex , Kappelman John
Published: August 2024

The East African Rift System (EARS) provides an opportunity to constrain the relationship between magmatism and plate thinning. During continental rifting, magmatism is often considered a derivative of strain accommodation—as the continental plate thins, decompression melting of the upper mantle occurs. The Turkana Depression preserves among the most extensive Cenozoic magmatic record in the rift. This magmatic record, which comprises distinct basaltic pulses followed by periods of relative magmatic quiescence, is perplexing given the lack of evidence for temporal heterogeneity in the thermo‐chemical state of the upper mantle, the nonexistence of lithospheric delamination related fast‐wave speed anomalies in the upper mantle, and the absence of evidence for sudden, accelerated divergence of Nubia and Somalia. We focus on the Pliocene Gombe Stratoid Series and show how lithospheric thinning may result in pulsed magma generation from a plume‐influenced mantle. By solving the 1D advection‐diffusion equation using rates of plate thinning broadly equivalent to those measured geodetically today we show that despite elevated mantle potential temperature, melt generation may not occur and thereby result in extended intervals of quiescence. By contrast, an increase in the rate of plate thinning can generate magma volumes that are on the order of that estimated for the parental magma of the Gombe Stratoid Series. The coincidence of large‐volume stratiform basalt events within the East African Rift shortly before the development of axial zones of tectonic‐magmatic activity suggests that the plate thinning needed to form these stratiform basalts may herald the onset of the localization of strain.
Targeting Lactobacillus johnsonii to reverse chronic kidney disease
Authors: Miao Hua , Liu Fei , Wang Yan-Ni , Yu Xiao-Yong , Zhuang Shougang , Guo Yan , Vaziri Nosratola D. , Ma Shi-Xing , Su Wei , Shang You-Quan , Gao Ming , Zhang Jin-Hua , Zhang Li , Zhao Ying-Yong , Cao Gang
Published: August 2024

Accumulated evidence suggested that gut microbial dysbiosis interplayed with progressive chronic kidney disease (CKD). However, no available therapy is effective in suppressing progressive CKD. Here, using microbiomics in 480 participants including healthy controls and patients with stage 1–5 CKD, we identified an elongation taxonomic chain Bacilli-Lactobacillales-Lactobacillaceae-Lactobacillus-Lactobacillus johnsonii correlated with patients with CKD progression, whose abundance strongly correlated with clinical kidney markers. L. johnsonii abundance reduced with progressive CKD in rats with adenine-induced CKD. L. johnsonii supplementation ameliorated kidney lesion. Serum indole-3-aldehyde (IAld), whose level strongly negatively correlated with creatinine level in CKD rats, decreased in serum of rats induced using unilateral ureteral obstruction (UUO) and 5/6 nephrectomy (NX) as well as late CKD patients. Treatment with IAld dampened kidney lesion through suppressing aryl hydrocarbon receptor (AHR) signal in rats with CKD or UUO, and in cultured 1-hydroxypyrene-induced HK-2 cells. Renoprotective effect of IAld was partially diminished in AHR deficiency mice and HK-2 cells. Our further data showed that treatment with L. johnsonii attenuated kidney lesion by suppressing AHR signal via increasing serum IAld level. Taken together, targeting L. johnsonii might reverse patients with CKD. This study provides a deeper understanding of how microbial-produced tryptophan metabolism affects host disease and discovers potential pathways for prophylactic and therapeutic treatments for CKD patients.
The structure and catalytic mechanism of a pseudoknot-containing hammerhead ribozyme
Authors: Zhan Xuelin , Wilson Timothy J. , Li Zhenzhen , Zhang Jingjing , Yang Yili , Lilley David M. J. , Liu Yijin
Published: August 2024

We have determined the crystal structure of a pseudoknot (PK)-containing hammerhead ribozyme that closely resembles the pistol ribozyme, with essentially identical secondary structure and connectivity. The activity is more sensitive to deletion of the G8 2’OH than to the absence of magnesium ions, indicating that the catalytic mechanism is the same as the extended hammerhead, and distinct from the pistol ribozyme. Here we show that nucleophilic attack is almost perfectly in-line, and the G8 2’OH is well positioned to act as general acid, being directed towards the O5’ leaving group, and 2.9 Å away from it. Despite the similarity in overall structure to the pistol ribozyme, the local structure close to the cleavage site differs, and the PK hammerhead retains its unique mechanistic identity and demonstrates enhanced activity over other hammerhead ribozymes under standard conditions.
p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells
Authors: Majewska Julia , Agrawal Amit , Mayo Avi , Roitman Lior , Chatterjee Rishita , Sekeresova Kralova Jarmila , Landsberger Tomer , Katzenelenbogen Yonatan , Meir-Salame Tomer , Hagai Efrat , Sopher Ilanit , Perez-Correa Juan-Felipe , Wagner Wolfgang , Maimon Avi , Amit Ido , Alon Uri , Krizhanovsky Valery
Published: August 2024

The accumulation of senescent cells promotes ageing and age-related diseases, but molecular mechanisms that senescent cells use to evade immune clearance and accumulate in tissues remain to be elucidated. Here we report that p16-positive senescent cells upregulate the immune checkpoint protein programmed death-ligand 1 (PD-L1) to accumulate in ageing and chronic inflammation. We show that p16-mediated inhibition of cell cycle kinases CDK4/6 induces PD-L1 stability in senescent cells via downregulation of its ubiquitin-dependent degradation. p16-expressing senescent alveolar macrophages elevate PD-L1 to promote an immunosuppressive environment that can contribute to an increased burden of senescent cells. Treatment with activating anti-PD-L1 antibodies engaging Fcγ receptors on effector cells leads to the elimination of PD-L1 and p16-positive cells. Our study uncovers a molecular mechanism of p16-dependent regulation of PD-L1 protein stability in senescent cells and reveals the potential of targeting PD-L1 to improve immunosurveillance of senescent cells and ameliorate senescence-associated inflammation.
An activity-regulated transcriptional program directly drives synaptogenesis
Authors: Yee Callista , Xiao Yutong , Chen Hongwen , Reddy Anay R. , Xu Bing , Medwig-Kinney Taylor N. , Zhang Wan , Boyle Alan P. , Herbst Wendy A. , Xiang Yang Kevin , Matus David Q. , Shen Kang
Published: August 2024

Although the molecular composition and architecture of synapses have been widely explored, much less is known about what genetic programs directly activate synaptic gene expression and how they are modulated. Here, using Caenorhabditis elegans dopaminergic neurons, we reveal that EGL-43/MECOM and FOS-1/FOS control an activity-dependent synaptogenesis program. Loss of either factor severely reduces presynaptic protein expression. Both factors bind directly to promoters of synaptic genes and act together with CUT homeobox transcription factors to activate transcription. egl-43 and fos-1 mutually promote each other’s expression, and increasing the binding affinity of FOS-1 to the egl-43 locus results in increased presynaptic protein expression and synaptic function. EGL-43 regulates the expression of multiple transcription factors, including activity-regulated factors and developmental factors that define multiple aspects of dopaminergic identity. Together, we describe a robust genetic program underlying activity-regulated synapse formation during development.
Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer’s disease model mice
Authors: Sasmita Andrew Octavian , Depp Constanze , Nazarenko Taisiia , Sun Ting , Siems Sophie B. , Ong Erinne Cherisse , Nkeh Yakum B. , Böhler Carolin , Yu Xuan , Bues Bastian , Evangelista Lisa , Mao Shuying , Morgado Barbara , Wu Zoe , Ruhwedel Torben , Subramanian Swati , Börensen Friederike , Overhoff Katharina , Spieth Lena , Berghoff Stefan A. , Sadleir Katherine Rose , Vassar Robert , Eggert Simone , Goebbels Sandra , Saito Takashi , Saido Takaomi , Saher Gesine , Möbius Wiebke , Castelo-Branco Gonçalo , Klafki Hans-Wolfgang , Wirths Oliver , Wiltfang Jens , Jäkel Sarah , Yan Riqiang , Nave Klaus-Armin
Published: August 2024

Amyloid-β (Aβ) is thought to be neuronally derived in Alzheimer’s disease (AD). However, transcripts of amyloid precursor protein (APP) and amyloidogenic enzymes are equally abundant in oligodendrocytes (OLs). By cell-type-specific deletion of Bace1 in a humanized knock-in AD model, APPNLGF, we demonstrate that OLs and neurons contribute to Aβ plaque burden. For rapid plaque seeding, excitatory projection neurons must provide a threshold level of Aβ. Ultimately, our findings are relevant for AD prevention and therapeutic strategies.