bluuebunny/crossref_metadata_2025 huggingface dataset:
Abuse of Firearms Performance by Law Enforcement of the Indonesian Police in the Ferdy Sambo’s Case
Authors: Martini Martini
Published: July 2023

Ownership and use of firearms by the general public or civilian, cannot be separated from several factors, particularly the security factor. For some people, possession of firearms is used to protect themselves, and for others, it may be used to commit crimes, including in the case of Ferdy Sambo. One of Ferdy Sambo's men who was also the shooting suspect, namely Bharada E, was considered to have possessed a weapon in a way that was not according to procedure, based on testimony at trial by one of the members who handled permits for weapons ownership, the complete documents from Bharada E and also the victim Brigadier J were incomplete, both of them have not taken a psychological test, an introduction to the work unit, and a doctor's certificate. Qualifications of Indonesian Police Number 12, 1951 About Changing “Ordonantietijdelijke Bijzondere Strafbepalingen” (Stblt. 1948 Number 17) and Old Indonesian Law Number 8, 1948. Criminal liability for perpetrators of possession of firearms without a permit according to Indonesian Law Emergency, 1951 about changing “Ordonanntietdelijke Bijzondere Strafbepalingen” (stblt. 1948 Number 17) and Indonesian Law Number 8, 1948 clearly set on Article 1 Whoever, without the right to enter Indonesia, makes, receives, tries, obtains, surrenders or tries to surrender, controls, carries, has in his possession, stores, transports, hides, uses, or takes out from Indonesia firearms, ammunition or anything explosives, is punishable by death penalty or life imprisonment or a maximum term of twenty years’ imprisonment.
Politeness Strategies in WhatsApp Text Messaging
Authors: Shalihah Miftahush , Winarsih Tri
Published: July 2023

Lecturers and students frequently interact in both formal and semi-formal settings. Communication between students and professors must, of course, be maintained in such a way that it is always polite, even in informal situations. The availability of social media undoubtedly enhances contact between teachers and students. However, the use of social media has an impact on the language style of lecturers and students. This research aims to explain and examine the ethics of lecturers when responding to students’ text messages using the WhatsApp messaging application. Furthermore, this study examines violations from etiquette norms in short messages from the lecturer to the students. This study was qualitative in nature. The primary data of this research were the screenshots of interactions between instructors and students via the WhatsApp messaging application. This research also employed observation, note-taking, and interviews. According to the preliminary study, there are still numerous short messages between lecturers and students that do not match the courtesy standard. The unfulfilled value of politeness is the use of slang, impolite ways of expressing intentions or the use of inappropriate linguistic aspects.
Aplicación del modelo e- learning y su efecto en el desarrollo de la técnica e interpretación musical en estudiantes de la especialidad de violín del conservatorio regional de música del norte público “Carlos Valderrama” 2021
Authors: Álvarez Moreno Angela Alejandrina , Santos Jiménez Ofelia Carmen , Ocaña-Fernández Yolvi , Teves Quispe Julia
Published: July 2023

El presente título “Aplicación del modelo E-learning y su efecto en el desarrollo de la técnica e interpretación musical en estudiantes de violín del Conservatorio regional de música del Norte “Carlos Valderrama” 2021, determinará el papel del e-learning en el desarrollo de la técnica e interpretación musical y su efecto en la aplicación de estudiantes de violín en instituciones superiores. La investigación es de tipo aplicada, correspondiente a un estudio explicativo de un diseño cuasi-experimental. Se utilizaron como población un total de 60 estudiantes de violín del conservatorio regional de música, de los cuales (30 personas) pertenecían al grupo experimental y (30 personas) al grupo control. Se realizó un diseño hipotético de investigación cuasi-experimental, se testeó el proceso de aprendizaje antes de utilizar el modelo e-learning (pretest) y se testeó a los estudiantes al final (postest) a través de un software de música interactivo y ficha técnica. Para el procesamiento de datos se utiliza el programa estadístico SPSS-25. Sus resultados encontraron que la aplicación del modelo e-learning tuvo un efecto positivo en el desarrollo de la técnica e interpretación musical de los estudiantes de violín, ya que el grupo experimental fue validado en la prueba de seguimiento en comparación con el control según la frecuencia alcanzada. La prueba de Wilcoxon y el grupo de prueba de hipótesis mostraron un efecto positivo en el resultado; del mismo modo, se verificó que hubo una diferencia significativa entre los resultados del pretest y postest del grupo experimental, y se concluyó que las actividades utilizadas durante el cuasi-experimento causaron un efecto positivo en los estudiantes en el desarrollo de la técnica de interpretación musical a través del e-learning.
Competencia directiva y gestión escolar en la IE 3711 Fe y Alegria 12. puente Piedra. Lima
Authors: Garabito Conislla , Flores Cabrera Jesús Ernesto , Sánchez Pinedo Luz Doris
Published: July 2023

Las competencias directivas influyen en el ascenso o perfeccionamiento con calidad de los aprendizajes y son una tendencia a nivel mundial por las implicancias que tiene no solo en la vida misma de los estudiantes sino porque repercute en la gestión escolar.  Nos inspiró por ello realizar un estudio sobre estas variables en la IE Fe y Alegría N. 12 de Puente Piedra en Lima. Su objetivo fue establecer si existía influencia entre las dos variables a través de un   análisis metodológico con enfoque cuantitativo, diseño de tipo explicativo, correlacional en una muestra de 31 docentes, pudimos comprobarlo. Por lo que a través de la aplicación del estadígrafo Rho de Spearman se contrasta la hipótesis y sus resultados nos induce a rechazar la hipótesis nula que dice que no ha relación significativa entre las dos variables y que efectivamente existe influencia positiva y significativa entre las competencias directivas y la gestión escolar de la muestra institucional. Al amparo de una significancia de 0.05
Cultura organizacional y gestión de la calidad del servicio educativo. IE n°3711 Fe y Alegría 12. Puente Piedra. Lima
Authors: Cámac Fernández Juan Carlos , Muñoz Sosa Rosario Del Pilar , Escalante López María Emperatriz
Published: July 2023

Un directivo administrador de la gestión de una institución educativa tiene responsabilidad en su conducción. La tendencia hoy en día es que los liderazgos directivos tienen vital importancia más aun el liderazgo directivo pedagógico pues conjuga su quehacer en relación al desempeño docente y su labor debe tener un marco transformador de modo que cambiando las condiciones de la escuela en función de un clima empático y autorregulado  a partir de  las buenas costumbres con honestidad, empatía y conocimiento se vea reflejado en un buen desempeño docente que redundará en el logro oportuno y adecuado de los aprendizajes. La dirección debe tener visión de futuro en medio de las tendencias globales de los que significa una revolución tecnológica donde el pensamiento computacional va adquiriendo relevancia en los planes de estudio. Nuestra investigación en el colegio N. 8180 pretende dar aportes en pos de la mejora de la organización que promueva una gestión educativa en favor del desempeño docente.  Es un estudio con enfoque cuantitativo, método hipotético deductivo, transversal, bivariado que trabajo con una muestra no probabilística de 40 docentes. Un análisis estadístico descriptivo e inferencial a través del estadígrafo Rho de Spearman, nos permite concluir que efectivamente en una prueba de contraste de hipótesis con una significancia de 0.05, una correspondencia r=0,746 equivalente a un porcentaje del 76.85 % nos permite concluir que el liderazgo directivo pedagógico se relaciona significativamente con la evaluación del desempeño docente. Que la planificación institucional (r=0,529, 54.30%) los temas financieros (r=0,557, 56.30%), la evaluación y rendición de cuentas (r=0,619, 63.80%) igualmente,  así como la gestión de los procesos pedagógicos (r=0,578, 59.30%) demuestran que efectivamente existe relación significativa del líder pedagógico y el desempeño docente en cada subdimensión.
Atmospheric Corrosion of Steel Infrastructure in Canada Under Climate Change
Authors: Ozkan Istemi F. , Ebrahimi Nafiseh , Zhang Jieying , Markovinovic Dario , Shirkhani Hamidreza
Published: July 2023

Protection against atmospheric corrosion of steel infrastructure and its components requires assessment and prediction of corrosion rates using quantitative and reliable modeling of the environmental parameters that impact the corrosion process. This has become even more critical in the context of climate change. This study demonstrates the feasibility of using ISO dose-response functions (DRFs) to classify atmospheric corrosiveness in Canada to improve the current qualitative approach to the corrosion design of carbon steel infrastructure, especially bridges. The DRF predictions for first-year corrosion rates were first validated using a set of historical field data collected from different locations across Canada. Further examination has revealed a dramatic change in atmospheric corrosiveness at many locations in Canada since the last systematic effort in field data collection in the 1950s to 1960s. It is believed that this was caused by a significant drop in in sulfur dioxide levels in the atmosphere. A projection of future corrosiveness in various Canadian cities with differing climates was also presented by considering the projected impacts of climate change on the temperature and relative humidity. This study has shown a promising precursor for the development of a corrosiveness map in Canada to better guide the corrosion design and protection of steel infrastructure. Furthermore, this study has demonstrated an acute need to understand the current chloride deposition conditions of steel bridges, including the increased local exposure of roadways to corrosiveness by the use of de-icing salts.
Electrochemical Study on Corrosion Damage of 7B04 Aluminum Alloy/Anodic Film/Epoxy Coating System in a Simulated Marine Atmospheric Environment
Authors: Ji Haodi , Ma Xiaobing , Cai Yikun , Wang Han
Published: July 2023

This paper investigates the electrochemical characteristics of the 7B04 aluminum alloy/anodic film/epoxy coating system in a simulated marine atmosphere using electrochemical techniques and surface morphology measurements. The coating system underwent a periodic immersion test for 480 h to simulate the harsh service conditions in a marine environment. Three equivalent circuit models were proposed based on the analysis of the electrochemical failure mechanism of the coating system. Akaike information criterion and Bayesian information criterion were used to selectively choose models for different degradation stages of the coating system, revealing its electrochemical degradation characteristics. Two-stage aging kinetics and gamma models were proposed to describe the time-varying processes of electrochemical low-frequency impedance and corrosion trend, respectively. Ultimately, low-frequency impedance is identified as the most effective and rapid evaluation index for coating performance due to its strong correlation with corrosion trends. The aforementioned models and index provide a foundation for accurately identifying corrosion stages and effectively predicting the corrosion process.
The Irish Background to the De XII abusiuis saeculi
Authors: Cróinín Dáibhí Ó
Published: July 2023

This chapter examines the Irishness of the De XII abusiuis saeculi. It does so with particular reference to Old Irish legal texts, in particular to the Archaic Old Irish text Audacht Moraind (‘The Testament of Morand’), believed by some scholars to predate even the De duodecim abusiuis (thereby placing it before c. AD 650 and earlier than every other Speculum Principis of the Middle Ages), and to the Senchas Már, the ‘Great Collection’ of early Irish laws. It discusses not just the parallels between DDAS and the legal texts, but the difficult question of which came first. There can be little doubt, however, about its original provenance in seventh-century Ireland.
Reflecting on Abuses in Religious Life
Authors: Mews Constant J.
Published: July 2023

The twelfth century is well-known for producing a number of well-known satires on abuses within religious life, notably by Bernard of Clairvaux. Less attention, however, has been given to a treatise of the Augustinian canon, Hugh of Fouilloy, about the twelve abuses of the cloister, clearly inspired by De XII abusiuis saeculi. Hugh then expanded this treatise into a two-book version, De claustro animae (On the Cloister of the Soul), subsequently enlarged into a four-book version. Hugh’s reflections, along with the original treatise on twelve abuses of the age, helped shape awareness of abuses in religious life for over three hundred years.
Addressing Abuses and Injustice in the Court of Philip the Fair
Authors: Lahav Rina
Published: July 2023

The De informatione principum, written for the future Louis X (r. 1314–1316), the eldest son of Philip the Fair and Jeanne of Navarre, gives instruction on the principles of just government through reflecting on Jeremiah (23. 5): A king shall reign and shall be wise and shall execute judgement and justice in the earth. I argue that this (as yet unedited) treatise was written by the Franciscan confessor to Jeanne of Navarre, Durand of Champagne, author of the Speculum dominarum. The verse of Jeremiah establishes the need for a king to identify and fix manifold injustices in the court and society. I argue that these injustices reformulate those identified in the Twelve Abuses of the Age within the very different context of the French royal court.
Exclusionary Texts in ‘A Common Word’
Authors: Speelman Gé
Published: July 2023

The open letter sent by prominent Muslim leaders to the Pope and the Christian community contains many references to texts from the Qur’ān and the Bible. Some of these texts can be interpreted as exclusionary texts vis-à-vis religious others. This contribution describes the ways in which the authors of A Common Word opt for alternative interpretations of a number of such texts, opening up possibilities for a more inclusionary understanding of both the Qur’ānic and Biblical approaches toward religious others.
RECOVERY OF USED LUBRICATING OIL BY GLACIAL ACETIC ACID WITH TWO DIFFERENT ACTIVATED CARBONS
Authors: Anisuzzaman S.M. , Jumaidi Mohammad Hafiz
Published: July 2023

Recovery of used lubricating oil (ULO) generally comprises cleaning, drying, and adsorption in order to eliminate water, sludge, and impurities. As the ULO is one of the hazardous wastes generated in various industrial and automotive industries, it should not be used or disposed of in ways that are harmful to the environment. The main purpose of this study was to investigate the effectiveness of two different types of activated carbons (ACs) which are coconut AC (CAC) and rice husk AC (RHAC) in recovering the ULO. Glacial acetic acid was used in the acid treatment as it does not react with the base oils, and the ACs were substituted with the clay used in the clay treatment. The recovered oil was analysed through analytical characterizations, which are Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible (UV-vis) spectroscopy and atomic absorption spectrometry (AAS). FTIR analysis revealed that the properties of the untreated ULO samples improved by removing the carbonyl compounds. In terms of metal removal, RHAC had shown better performance than CAC as it gave low metal contents in AAS. The response surface methodology (RSM) was used to study the optimum process parameters that would maximise the efficiency of the process. There are two factors that were manipulated, which are the weight of adsorbent (A) and speed of mixing (B). For CAC, the optimum value of factors A was 4.00 g while the B was set to 524.89 rpm.  Meanwhile, for RHAC, the optimum value of factors A was 2.29 g while the B was set to 4000 rpm. CAC has higher desirability with 0.83 compared to RHAC with 0.69.
Use of NUTrition Risk in the Critically Ill and Modified NUTrition Risk in the Critically Ill with C-Reactive Protein Scores as a Prognostic Indicator in COVID-19 Patients
Authors: Çalışkan Gülbahar , Küçükdemirci Kaya Pınar , Dikici Mustafa , Kelebek Girgin Nermin
Published: July 2023

Objective: This study aimed to investigate the applicability of the NUTrition Risk in the Critically Ill and modified NUTrition Risk in the Critically Ill with C-reactive protein scores for assessing nutritional risks and predicting outcomes of these critically ill coro- navirus disease 2019 patients.
Methods: This retrospective study included 246 adult patients admitted to the intensive care unit between March 15, 2020, and August 15, 2021, diagnosed with coronavirus disease 2019 which was confirmed with real-time-polymerase chain reaction, and who received invasive mechanical ventilation. Treatments in the intensive care unit and clinical outcomes of the patients were recorded. The nutritional risk for each patient was assessed using both the NUTrition Risk in the Critically Ill and the modified NUTrition Risk in the Critically Ill with C-reactive protein scores. If the NUTrition Risk in the Critically Ill and modified NUTrition Risk in the Critically Ill with C-reactive protein scores were ≥6, and the nutritional risk was considered to be high.
Results: The median age was 68 (21-93) years, and 61% of them were male. The median duration of invasive mechanical ven- tilation was 9 (1-62) days, the median length of stay in intensive care unit was 15 (1-65) days, and the mortality rate in 28 days was 77.2%. Most of the patients had low nutritional risk according to NUTrition Risk in the Critically Ill score (75.2%) and modi- fied NUTrition Risk in the Critically Ill with C-reactive protein score (69.1%). High NUTrition Risk in the Critically Ill and modified NUTrition Risk in the Critically Ill with C-reactive protein scores were not significantly associated with the duration of invasive mechanical ventilation, length of stay in intensive care unit, and mortality at 28 days.
Conclusion: It was shown that NUTrition Risk in the Critically Ill and modified NUTrition Risk in the Critically Ill with C-reactive protein scores were not correlated with the duration of invasive mechanical ventilation, length of stay in intensive care unit, and 28-day mortality in critically ill coronavirus-19 patients. NUTrition Risk in the Critically Ill score was not an appropriate nutrition risk assessment tool as a prognostic marker in patients with severe acute respiratory syndrome coronavirus 2 infection, which is correlated to interleukin-6 and C-reactive protein levels.
Presentación del V Congreso de Investigación Clínica de la Asociación Colombiana de Hematología y Oncología Clínica
Authors: Ramos Guette Pedro
Published: July 2023

En el mes de noviembre de 2022 se realizó en la ciudad de Barranquilla el quinto Congreso Nacional de la Sociedad Colombiana de Hematología y Oncología Clínica (ACHO) en Investigación Clínica, evento que convocó a las diferentes especialidades que se enfrentan a diario con los retos que implican la promoción, prevención, diagnóstico, tratamiento, rehabilitación y cuidados paliativos en los pacientes con cáncer.
Propuesta de una matriz de decisión multicriterio (MCDA) para la evaluación de medicamentos en oncología
Authors: Pino Luis , Ordoñez Jaime , Palomares Lila , González Ana , Lema Mauricio , Triana Iván
Published: July 2023

Contexto y Objetivo: la complejidad del cáncer no es exclusivamente biológica; su estructura de costos genera presión sobre los sistemas de salud derivada de la innovación tecnológica, la cual tiene una inmensa velocidad y variabilidad. Por este motivo, los análisis de las tecnologías en salud deben evolucionar para abarcar las nuevas realidades y desenlaces derivados de la oncología moderna y poder así definir las nuevas inclusiones, pero también determinar el verdadero valor terapéutico. Bajo esta óptica se desarrolló una propuesta metodológica consistente en una matriz multicriterio para la decisión (MCDA), aplicada en el escenario clínico de la inmunoterapia para el tratamiento del cáncer de pulmón de célula no pequeña metastásico o avanzado, en el cual dichos medicamentos han cambiado el panorama de resultados clínicos.
Perfiles composicionales de la fórmula leucocitaria como predictores de enfermedad severa en pacientes con infección por SARS-CoV2
Authors: Enciso Olivera Leonardo José , Rodríguez Romero Viviana Alejandra , Mejía Cano Angie Lorena
Published: July 2023

Objetivo: La predicción del riesgo de desarrollar enfermedad severa o crítica en pacientes con infección por SARS-CoV2 requiere la utilización de modelos complejos que incluyen variables clínicas y prueba de laboratorio que no estándisponibles en todos los centros que atienden esta población. Diferentes variaciones de la relación entre poblaciones de leucocitos han demostrado tener implicaciones pronosticas, posiblemente asociadas con mecanismos fisiopatológicos. Alser el hemograma una prueba ampliamente disponible el desarrollo de un modelo de asociación para identificar los casos con mayor riesgo de enfermedad severa o crítica basado en las alteraciones propias del mismo, puede permitir su aplicación en diferentes escenarios clínicos con recursos limitados. El objetivo principal de este estudio fue establecer si existía asociación entre la composición de la fórmula leucocitaria al momento del diagnóstico y el desarrollo de enfermedad severa, críticao muerte en pacientes de 18 años o más con diagnóstico confirmado de infección por SARSCoV2. Los objetivos específicos fueron describir los perfiles composicionales de la fórmula leucocitaria al momento de la presentación inicial en pacientescon infección por SARS-CoV2, utilizando los métodos de análisis composicional, describir las características clínicas, alteraciones de laboratorio y supervivencia global de los pacientes mayores de 18 años con infección con SARS-CoV2 e identificar variables clínicas o de laboratorio asociadas con el riesgo de desarrollar enfermedad severa, crítica o muerte en pacientes mayores de 18 años con infección por SARS-CoV2.
Experiencia con uso de brentuximab vedotin como primera línea de tratamiento en pacientes adultos con linfoma Hodgkin en estadio IV que asisten al Instituto Nacional de Cancerología
Authors: Chaves Karen Milena , Bohórquez Tibavisco Leonardo , Spirko Sánchez María Paola , Martínez Cordero Humberto , Ospina Idarraga Juan Alejandro , Martínez Correa Lina María , Pereira Garzón Alberto Mario , Valdés Céspedes Jaime Fernando , Alcalá Sebastián , Arbeláez Monroy María Isabel
Published: July 2023

Objetivo: describir los desenlaces clínicos obtenidos en pacientes con diagnóstico de linfoma Hodgkin en estadio IV que recibieron brentuximab vedotin+AVD como primera línea de tratamiento en el Instituto Nacional de Cancerología. Materiales y Métodos: estudio observacional descriptivo, de características retrospectivas, en el cual se revisaron los registros de las historias clínicas de pacientes que asistieron al Instituto Nacional de Cancerología con diagnóstico de linfoma Hodgkin que tenían estadio IV y recibieron brentuximab vedotin+AVD como primera línea de tratamiento. Este estudio fue aprobado por elComité de Ética institucional en cumplimiento de la normatividad colombiana en investigación. Se describieron características sociodemográficas, clínicas, tasas de respuesta global, respuesta completa y parcial tanto en valoración intermedia como al final del tratamiento. El análisis estadístico fue realizado mediante el R-Project versión 3.6.2 y SPSS versión 25. Las variables incluidas en el estudio fueron descritas de forma estándar, siendo la mediana y el rango intercuartílico la medida de tendencia central en el caso de las variables de naturaleza continua. En el caso de las variables cualitativas, estas fueron representadas mediante frecuencias absolutas y relativas.
Mejoramiento de la calidad de vida y adherencia al tratamiento en pacientes con mieloma múltiple mediante el uso de estrategias educativas digitales basadas en aprendizaje
Authors: Guio Juan Francisco , Melo Andrés , Fuentes Cynthia , Tijaro Natalia , Borda Andrés , Bolaño Elías , Quintero Guillermo , Duarte Mónica , Agudelo Claudia , Cuellar Gina , Páez Marco , Bernal Patricia , Rueda Erica , Aparicio Soraya , Pinzón Oscar , Romero Martha Liliana
Published: July 2023

Objetivo: El mieloma múltiple (MM) es la segunda neoplasia hematológica más frecuente, con alta morbilidad y mortalidad, caracterizada por una proliferación clonal de células plasmáticas que infiltra médula ósea y otros órganos generando daño, manifestado en la anemia, falla renal, compromiso óseo, hipercalcemia, infecciones, entre otras. Para lograr mejores desenlaces y calidad de vida es necesario un adecuado control de la enfermedad y de los síntomas. La mejor adherencia al tratamiento y el fortalecimiento de la educación podrían impactar positivamente en estos procesos. El objetivo de nuestro estudio es medir el impacto de una nueva estrategia educativa digital, auto-dirigida y personalizada en la adherencia al tratamiento, control de complicaciones y el mejoramiento de la calidad de vida en los pacientes con MM.
Mutaciones en los genes PIK3c2B, ERBB3, KIT y MLH1 se correlaciona con la resistencia al uso de temozolomida en pacientes con gliomas de alto grado
Authors: Ortiz Gómez León Darío , Peláez Ronald Guillermo , Contreras Heidi Johana
Published: July 2023

Introducción: el tratamiento en los pacientes con gliomas de alto grado incluye radioterapia y temozolomida. La temozolomida metila las guaninas del ADN, lo cual conlleva a errores de apareamiento entre la guanina y la citosina, cambiándose esta última por timina, lo cual activa el sistema de reparación de errores de emparejamiento del ADN (DNA mismatch repairMMR), el cual repara solo la cadena con la timina, dejando intacta la que tiene la guanina metilada. Estos errores generan apoptosis celular en las células cancerígenas. No obstante, algunos pacientes no responden a la temozolomida, ya que tienen un mecanismo de reversión de la metilación mediante la enzima O6-metilguanina DNA-metiltransferasa (MGMT). La transcripción del gen que codifica para la proteína MGMT está regulado por la metilación de su promotor. Los promotores metilados bloquean la producción de la enzima, mientras los no metilados favorecen su transcripción. Este biomarcador se ha utilizado como un factor pronóstico en los pacientes en tratamiento con temozolomida, esperándose que los pacientes que no producen la enzima respondan al tratamiento. Sin embargo, no todos los pacientes responden de forma similar, lo cual sugiere que deben existir otros genes involucrados con la resistencia a la temozolomida.
Desenlaces de trasplante alogénico de progenitores hematopoyéticos con esquemas de acondicionamiento a base de busulfán e injertos de sangre periférica en pacientes con leucemias agudas de alto riesgo
Authors: Pereira Garzón Alberto Mario , Valdés Céspedes Jaime Fernando , Martínez Correa Lina María , Ospina Idarraga Juan Alejandro , Martínez Cordero Humberto , Spirko Sánchez María Paola , Chaves Karen Milena , Alcalá Sebastián , Arbeláez Monroy María Isabel , Bohórquez Leonardo
Published: July 2023

Objetivos: determinar los desenlaces clínicos de pacientes mayores de 15 años con leucemias agudas (LA) de alto riesgo sometidos a TPH con esquemas de acondicionamiento a base de busulfán e injertos de sangre periférica (PB). Materiales y Métodos: describimos los desenlaces de supervivencia libre de recaída (RFS), supervivencia global (OS), mortalidad relacionada con el trasplante (TRM), recaída postrasplante de pacientes con AL de alto riesgo que fueron llevados a TPH con acondicionamientos a base de busulfán e injertos de PB. Se analizaron los datos mediante R-Project versión 3.6.2 y SPSS versión 25. Se realizó un análisis multivariado con un modelo de regresión de riesgos proporcionales de Cox para buscar asociaciones con recaída postrasplante.
Tasa de supervivencia a cinco años en pacientes diagnosticados con mieloma múltiple y sus factores asociados, en una institución prestadora de servicios de salud de Medellín entre 2013 a 2021
Authors: Jaramillo Arbeláez Patricia Elena , Jeniffer Jeniffer , Gálvez Cardenas Kenny Mauricio , Salazar Flórez Jorge Emilio
Published: July 2023

Objetivos: Mieloma múltiple, supervivencia global, supervivencia libre de progresión. Introducción: el mieloma múltiple es una neoplasia clonal de células B, que se presenta por la acumulación de células plasmáticas neoplásicas en la médula ósea. Es la segunda neoplasia hematológica más frecuente (15%), responsable de casi el 20% de todas las muertes relacionadas con neoplasias hematológicas. La mediana de supervivencia es de aproximadamente 6 a 7 años.
Características clínicas y supervivencia de una cohorte de pacientes con cáncer de mama triple negativo en un país de recursos medios
Authors: Ramos Pedro , Athenas Ramos María , Silva Diana
Published: July 2023

Objetivos: 1) Evaluar la supervivencia global de pacientes con cáncer de mama triple negativa no metastásico, 2) Evaluar la supervivencia libre de enfermedad de pacientes con cáncer de mama triple negativo no metastásico y, 3) Evaluar la asociación de factores pronósticos con desenlace de supervivencia global y libre de enfermedad.Métodos: este estudio se realiza con la información de la Clínica Oncocare en el periodo comprendido entre el 1° de enero del 2007 hasta el 31 de diciembre de 2021. Se incluyeron todas las pacientes con diagnóstico de cáncer de mama triple negativo no metastásico (estado I a IIIC). Se realizaron descripciones de las características clínicas y demográficas con estadística descriptiva, medidas de tendencia central y dispersión. Se construyeron curvas de supervivencia con el método de Kaplan-Meier, se compararon con método rangos logarítmicos y se realizó regresión de Cox.
Cáncer de pulmón de célula pequeña en el Instituto Nacional de Cancerología
Authors: Bruges Ricardo , Ballén Diego , Jurado Natallie , Beltrán Rafael , Alarcón Martha Liliana , Vallejo Camilo , Núñez Marcela , Parra Rafael , Carvajal Carlos
Published: July 2023

Objetivos: el objetivo de este estudio fue describir las características clínicas, los resultados de supervivencia y los factores asociados con el pronóstico de los pacientes con cáncer de pulmón de célula pequeña (CPCP) manejados en el Instituto Nacional de Cancerología (INC) entre 2013 y 2018
¿Cáncer de Próstata T1c, una única enfermedad con buen pronóstico?
Authors: Villegas Mejía Carlos Raúl , Villegas Jaramillo Manuel , Villegas Jaramillo Pedro , Rojas Uribe Gustavo Adolfo
Published: July 2023

Introducción: se analiza el perfil epidemiológico de pacientes con cáncer de próstata en subetapa clínica T1c definido como el diagnóstico por biopsia en pacientes con enfermedad no palpable, solo con un nivel de PSA elevado, representando el tercer cáncer más común y la primera neoplasia en hombres en nuestra área.
Mecanismos de resistencia a osimertinib de primera línea en pacientes hispanos con cáncer de pulmón de células no pequeñas mutante en EGFR
Authors: Cardona Zorrilla Andrés Felipe , Ruiz Patiño Alejandro , Sotelo Rodríguez Diana Carolina , Santoyo Sarmiento Nicolás David , Mejía Espinosa Sergio Andrés , Jaller Corrales Elvira Isabel , Carranza Isaza Hernán , Otero Bernal Jorge Miguel , Rodríguez Ariza July Katherine , Archila Gómez María del Pilar , Bermúdez Díaz Maritza Alejandra , Gámez Porras Yarlin Tatiana , Polo Torres Carolina , Viola Muñoz Lucia Carolina , Vargas Báez Carlos Alberto
Published: July 2023

Introducción: el osimertinib es un EGFR-TKI de tercera generación aprobado para el tratamiento del cáncer de pulmón de célula no pequeña (CPCNP) en estadio avanzado, inicialmente en el escenario de recaída con mutación T790M, actualmente también aprobado como tratamiento de primera línea. Uno de los principales desafíos en el tratamiento de pacientes con terapias dirigidas es la aparición de resistencia a los medicamentos, impulsada por la aparición de mecanismos biológicos que dan lugar a mecanismos de escape del tumor adquiridos que se conocen parcialmente. Uno de los mejores ejemplos es la resistencia a los inhibidores de la tirosina quinasa (TKI) del EGFR de primera o segunda generación por la mutación EGFR T790M. La mutación T790M disminuye la afinidad de los TKI de primera y segunda generación por el bolsillo de unión a ATP de EGFR. En este contexto, el osimertinib TKI de tercera generación, dirigido tanto a la resistencia T790M como a las mutaciones sensibilizantes del EGFR restaura la vía de señalización descendente del EGFR. Cada vez hay más evidencia sobre los mecanismos de resistencia al osimertinib en el entorno de primera línea; sin embargo, los datos sobre la población hispana y la progresión después del tratamiento son escasos
Análisis de eficiencia presupuestal (ahorro) generado en el sistema de salud colombiano debido a la implementación de estudios clínicos oncológicos con financiación externa
Authors: González Fernández Manuel Enrique , Aruachan Vesga Sandra Eugenia , Duque Santiago , Mestra Rojas Danis , Ángel Andrés , Ospina Martínez Javier
Published: July 2023

Objetivo: desarrollar un análisis de impacto presupuestal que permita evidenciar el costo total del tratamiento financiado, gracias al ingreso oportuno de estudios clínicos oncológicos y a un 100 % de adherencia a los protocolos y tratamientos. Además, evidenciar el ahorro generado en las finanzas del sistema de salud colombiano, basado en la implementación de estudios clínicos para patologías oncológicas, con una financiación externa, en el área de investigación de IMAT Oncomédica. También medir el ahorro en el presupuesto de las aseguradoras, gracias a la financiación externa de los estudios de investigación, por cada paciente/cohorte ingresada en el estudio clínico oncológico.
Reporte de cuatro casos con carcinoma neuroendocrino de próstata
Authors: Quiroga Echeverri Alicia , González Pérez Luis Gabriel , Arango Rivas Ana María
Published: July 2023

Objetivos: describir cuatro casos de pacientes con carcinoma neuroendocrino de próstata
THE REASON FOR THE DEATH OF A PERSON IN CASE OF REFUSAL OR TERMINATION OF OFFICE WORK: PROBLEMS AND SOLUTIONS
Authors:   University of Public Security of the Republic of Uzbekistan, Ataniyazov Jasurbek
Published: July 2023

This article discusses the procedural problems associated with the refusal or termination of proceedings in connection with the death of a person, as well as aspects of the legal regulation of these issues. The article also discusses the problems associated with the fact that the procedural status of the person to be brought as an accused in a criminal case was preserved in the legislation at the time of his death, but there was no further mechanism for resolving the case of his death during the pre-trial investigation and during the procedural period associated with the status of the person as a suspect and the subject of a legal conflict. The existing legal gap in the application by civil courts to the Criminal Procedure Legislation of the legal consequences of recognizing persons as deceased has been studied both theoretically and practically. According to this analysis, proposals have been developed for amendments and additions to the relevant legislative and by-laws to improve legislation. The article also systematically presents the state and analysis of the reflection in the legislation of the legal consequences associated with the deaths of individuals. The study used such methods as analysis, synthesis, induction, deduction, and comparative legal analysis. The research work analyzes advanced foreign experience, scientific and theoretical views, and investigative and judicial practice.
THE CONCEPT AND CHARACTERISTIC SIGNS OF THE CRIME OF PROFESSIONAL FAILURE TO FULFILL DUTIES
Authors:   Tashkent State University of Law, Shukhratjon Khaydarov
Published: July 2023

This article describes the concept of the crime of improper performance of duties by medical personnel, specific features of the crime, and issues related to the basic concepts of this crime. Also, it is based on the article that the crime of medical personnel not performing their duties properly is increasing year by year in our republic, which means that there is a need to further improve the system of combating these crimes. In addition, the main concepts of the crime of improper performance of duties by medical personnel were analyzed based on the opinions of scientists. In addition, in the article, the shortcomings of the legal norms related to ensuring the proper performance of their duties by medical personnel, the insufficient level of legal protection of the relevant permitting or prohibiting systems in the field of public services, and some relations are also based on the fact that there are cases like insufficient regulation. In the article, suggestions and recommendations are also given regarding the improvement of the legal norms, which stipulate responsibility for the crime of improper performance of duties by medical personnel.
FUNDAMENTALS OF ENSURING THE SAFETY OF PARTICIPANTS IN CRIMINAL PROCEEDINGS AT THE JUDICIAL STAGES
Authors:   University of Public Safety Republic of Uzbekistan, Umarkhonov Azizkhon
Published: July 2023

Strengthening guarantees of citizens’ rights and freedoms, further consolidation of their personal, social, economic, and other rights in legislation, and ensuring genuine independence and openness of the justice system, in turn, require the adoption of appropriate regulatory legal acts, amendments, and additions to existing ones, as well as the abolition of certain legislative acts. Further strengthening of human rights guarantees when considering cases in courts and the implementation of the principle of adversarial parties are today’s most important links in a just society. Taking into account the need for scientific (doctrinal) substantiation in the article of the problem of ensuring the safety of participants in criminal proceedings at judicial stages and sufficient accumulation of the quantitative part of scientific research, along with the adopted legal acts. It was effective to apply measures of criminal procedural security in judicial practice, both for a person contributing to criminal justice and for other participants in modern criminal proceedings. Several opinions and considerations have been expressed on this issue.
ORGANIZATIONAL AND LEGAL ISSUES OF STATE SUPPORT FOR INTELLECTUAL PROPERTY RIGHTS MANAGEMENT AND TECHNOLOGY TRANSFER
Authors:   Tashkent State University of Law, Khojaev Bakhshillo
Published: July 2023

This article discusses the role and importance of state support in the management of intellectual property rights and technology transfer. The issues of domestic and foreign experience of state programs in this direction are discussed. In particular, the organizational and legal framework of IT technology transfer in Uzbekistan, as an example of India and the Republic of Belarus, was analyzed. The aspect of state participation in intellectual property management from the perspective of not only public but also private law is touched upon. This is demonstrated by the experience of the European Union. At the same time, the issues of improving contractual and legal mechanisms for regulation of technology transfer in IT parks and the expected results were discussed. Comparative legal analysis, methods of logical interpretation, and systematization were chosen as the main methods in this study. Also in the study, the expression of norms of technology transfer is analyzed, and ideas for further improvement of the existing situation in comparison with the legislation of foreign countries are put forward.
THE CONCEPT OF AN INTERNATIONAL CONSTRUCTION CONTRACT
Authors:   University of World Economy and Diplomacy, Murodjonova Mokhirakhon , Imamova Dilfuza ,   University of World Economy and Diplomacy
Published: July 2023

The article explores the concept of an international construction contract. The relevance of this topic is due to the increase in the number of international construction contracts concluded and the growth of disputes in courts, which creates the need to qualify contracts with a foreign element. Despite the rapid pace of urbanization and the development of construction, in particular international construction, the concept of an international construction contract has not yet been formulated either in the convention order or in the legislation of countries. In the doctrine of private international law, the opinions of scientists differ in the formation of this concept. However, against the backdrop of the development of international construction, it is worth formulating the concept of an international construction contract, both in the doctrine and in the legislation of the country, for the further development of this industry. The information in the article is based on the opinions of domestic and foreign scientists, as well as the legislation of various countries. The formation of the concept of an international construction contract opens the way not only for the development of the scientific component of construction law but also creates fertile ground for the proper resolution of disputes arising from international construction contracts and the improvement of construction law.
THEORETICAL AND LEGAL ASPECTS OF THE CONCEPT OF FOREIGN INVESTMENTS
Authors:   Tashkent State University of Law, Yuldashbekov Avazbek , Kadyrova Dildora ,   Tashkent State University of Law
Published: July 2023

Protection of the rights of foreign investments and investors, improvement of legal documents for their registration, and determination of prospects in a market economy are one of the urgent tasks of our time. The reforms consistently carried out by our state in the social and economic spheres are yielding positive results. Today, when foreign enterprises and joint ventures with foreign investments operate in our republic, we can observe that, first of all, laws have been adopted that protect their rights and interests, and due to this, investment transparency has been ensured. Despite the ongoing reforms, the analysis shows that foreign investors do not have full rights to carry out their activities, the mechanism for their implementation is not sufficiently developed, and the presence of certain obstacles, including conflicting norms in the legislation, indicates the need to explore this area. This article analyzes the interpretation of the concept of “foreign investment” in our national legislation and the attitude of scientists toward this concept.
LEGAL REGULATION OF CONSULTING SERVICES
Authors:   Tashkent State University of Law, Asadov Shahriddin
Published: July 2023

Consulting services have become an integral part of modern business, and regulatory oversight is necessary to ensure that they operate ethically and professionally. In recent years, the consulting industry has experienced tremendous growth due to the growing demand for professional expertise and market knowledge. However, the industry has also faced numerous legal and ethical challenges, which have revealed the need for even more effective legal regulation. In this article, in order to determine more effective methods of regulation, various legal issues related to the provision of consulting services were discussed. Applying several general and private legal methods of legal research as a cognitive method, a method of analysis and synthesis, etc., the analysis of the legal conjuncture of the consulting services market was carried out. As a result of this work, results have been obtained in the form of scientific definitions and when applied can be effective tools for the legal regulation of consulting services.
Gamification in teachers for the teaching of history at the baccalaureate level
Authors: Quinto Saritama Enrique Vicente , Romero Serrano Marjorie Maribel , Fajardo Fajardo Jonathan Patricio , Jiménez Calva Rubia Estrella , Logroño Mendoza Henry Nicolas
Published: July 2023

The present work is based on a didactic proposal in gamification as a teaching strategy for the subject of History, in order to provide teaching staff with an approach towards the application of this strategy as a response to the problems that arise in the classroom classes at the time of having a continuous traditionalist methodology. The methodological change constitutes for the teacher the overcoming of traditional linear approaches, for this reason the importance of innovating the teaching methodology with activities that motivate and promote the integral formation of students is exposed (Fidalgo, 2020), likewise, it is detailed in detail. clear and simple the elements of a gamified project that allow its joint development. The activities proposed in this project have the purpose of developing together with the participants a didactic unit in the subject of history and they can acquire by themselves an experience in gamification, facilitating its implementation in the classroom and above all serving as a reference for the next projects that each participant plans to carry out, according to the needs of their students and the theme that is being taught.
ADOLESCÊNCIA E A ESCUTA PSICANALÍTICA
Authors: Rocha Vânia Lúcia Rodrigues , Góis Arquimedes Martins , Reis Orimar Batista dos
Published: July 2023

Este trabalho tem o objetivo de analisar o adolescente contemporâneo, bem como seus desconfortos, questionamentos, buscas, encontros e desencontros. Neste sentido o presente estudo pretende investigar, refletir e contribuir, a partir da escuta psicanalista, sobre características e particularidades desse adolescente frente aos desafios e mudanças em seu desenvolvimento físico, emocional, intelectual e social, que provocam alterações em seu comportamento, muitas vezes não compreendido pela família e sociedade. Esse ser humano adolescente está em processo de formação e amadurecimento psíquico e é constantemente bombardeado pela mídia, com seus poderes apelativos, muitas vezes causando inversões de valores, inseguranças e medos, principalmente pela ditadura da beleza, gerando angústia, insatisfação e infelicidade, por não se considerar dentro deste padrão. É necessário que o psicanalista tenha conhecimento dos fatores angustiantes desse adolescente que está em seu divã trazendo sua demanda, apresentando sintomas físicos e emocionais para ajudá-lo a enfrentar esta fase da melhor maneira possível. Sendo fundamental que o analista ouça o adolescente com afetividade e atenção e conduza-o a uma vida menos estressante, com mais saúde mental. A escuta ocupa um lugar importantíssimo na psicanálise por ela analisar palavras ditas e silenciadas, palavras que causam inquietudes, desconfortos, medo, insegurança, mas ao serem ditas abrem acesso a ressignificação.