bluuebunny/crossref_metadata_2025 huggingface dataset:
Motivational Interviewing Implementation in Primary Care: A “Terrifying Challenge” Becoming a “Professional Revelation”
Authors: Langlois Sophie , Goudreau Johanne
Published: December 2022

Introduction

Motivational interviewing (MI) is an evidence-based counseling approach within primary care. However, MI rarely translates to practice following introductory training programs, and a lack of evidence regarding its implementation persists today. This study describes primary care clinicians’ professional transformation in implementing MI through interprofessional communities of practice (ICP-MI).

Method

Qualitative data collection involved the research journal, participant observation of four ICP-MIs (76 hours/16 clinicians), and focus groups. A general inductive approach was used for data analysis. Results were conceptualized based on the Consolidated Framework for Implementation Research.

Results

Four processes of MI implementation in primary care are presented as a motivational endeavor: ambivalence, introspection, experimentation, and mobilization. The clinicians were initially ambivalent, taking into consideration the significant challenges involved. After introspecting actual practices, they realized the limits of their previous clinician-centered approaches. The experimentation of MI in the workplace followed and enabled clinicians to witness MI feasibility and its added value. Finally, they were mobilized to ensure MI sustainability in their practices/organization. Intrinsic factors of influence included the clinicians’ personal traits and their perception about MI as a clinical priority. Organizational support was also a crucial extrinsic factor in encouraging the clinicians’ efforts.

Conclusion

As described in a fragmented manner in previous studies, MI implementation processes and influencing factors are presented as integrated findings. Incorporating engaging educational activities to provide clinicians with motivational support and collaborating with health care organizations to plan appropriate resources should be considered in the development of MI implementation programs from the onset.
Transformation of Consumer Expectations for Well-Being in Hospitality: A Systems Framework
Authors: Zhang Lu , Wei Wei , Yu Heyao (Chandler) , Sharma Amit , Olson Eric D.
Published: December 2022

Systemic shifts in consumer preferences and expectations are not new, and can often be accelerated by major environmental events. Early evidence suggests that the events of 2020 to 2021 may have created that acceleration to fundamentally alter future consumer preferences. In this study, we argue that consumer expectations are on the path to being essentially transformed. If so, such transformations will require a renewed focus on consumer preferences in the context of an ecosystem comprised of the macro-, meso-, and micro-level factors impacting these changes. Changing consumer expectations will also need to be articulated and incorporated more comprehensively to include physical, mental, and social wellbeing. In this study, we argue that consumer behavior research will need to incorporate these fundamental shifts in factors impacting consumer preferences. We present a conceptual framework that incorporates the changing landscape of factors influencing this transformation along with suggestions for future research, and theoretical and practical implications.
Advantages and Limitations of Monitoring Circulating Tumor DNA Levels to Predict the Prognosis of Patients Diagnosed With Gastric Cancer
Authors: He Wan , Yang Jingxin , Sun Xiao , Jiang Shunda , Jiang Jinchan , Liu Ming , Mu Tianhao , Li Yingmei , Zhang Xiaoni , Duan Jingxian , Xu Ruilian
Published: December 2022

Next-generation sequencing-based genomic profiling facilitates biomarker detection by cell-free DNA (cfDNA) liquid biopsy. However, the efficiency of mutation calling and the prognostic value of cfDNA biomarkers are disputed. We investigated 24 patients with gastric cancer in this study, using a 605-gene sequencing panel to sequence their plasma cfDNA and tumor tissue DNA. The mutation concordance between plasma cfDNA and tumor tissue DNA was 70.6% in stage IV gastric cancer and 30.2% in stage III gastric cancer, indicating insufficient mutation detection rates in stage III and early-stage cancer. When compared with total cfDNA load and blood tumor mutation burden (bTMB), the variant allele frequencies (VAF) of commonly mutated genes are highly accurate in representing disease burden. Further, VAF are a better prognostic indicator compared with serum biomarkers including carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), cancer antigen 125 (CA125), and alpha-fetoprotein (AFP). The use of cfDNA in molecular profiling of patients allows prediction of patient survival and clinical response, as well as the development of personalized therapy regimens.
The Tri-iodothyronine (T3) Level Is a Prognostic Factor for Patients With Advanced NSCLC: Receiving Immune Checkpoint Inhibitors and Is Associated With Liver Metastasis
Authors: Kim Yoonjoo , Koh Jeong Suk , Woo Seong-Dae , Lee Song-I , Kang Da Hyun , Park Dongil , Chung Chaeuk , Kwon In-Sun , Lee Jeong Eun
Published: December 2022

Background:

Endocrine hormones influence tumor progression and the response to treatment. Despite the importance of immune checkpoint inhibitors (ICIs) as treatments for advanced non-small cell lung cancer (NSCLC), few studies have explored the effects of hormone levels in NSCLC patients on the effectiveness of ICI therapies. We thus investigated the effects of baseline blood markers in patients with advanced NSCLC on ICI treatments.

Methods:

Patients with advanced NSCLC who received programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors at Chungnam National University Hospital between December 2016 and November 2020 and who lacked any history of thyroid gland-related diseases were analyzed retrospectively. We collected clinical information and baseline laboratory data, including the levels of endocrine hormones, cytokines, complete blood counts (CBCs), and peripheral blood chemistry panels. We explored the relationships of hormone levels with clinical outcomes (overall survival [OS], progression-free survival [PFS], and best response), liver metastasis, and blood markers using the Kaplan–Meier method, Cox’s proportional hazards regression, and logistic regression.

Results:

A total of 113 patients were enrolled. A shorter PFS was independently associated with liver metastasis, higher cortisol levels, and lower hemoglobin (Hb) levels; a shorter OS was associated with liver metastasis, lower tri-iodothyronine (T3) levels, higher lactate dehydrogenase (LDH) levels, and lower albumin levels. Patients with low T3 levels exhibited a shorter PFS and OS, and a poorer best response. Patients with low T3 levels tended to have higher disease progression rates, lower levels of adrenocorticotropic hormone (ACTH), C-peptide, albumin, Hb, and neutrophil-to-lymphocyte ratio, and higher levels of interleukin (IL)-6, white blood cells, platelets, compared with those with normal T3 levels. We found a significant association between a low T3 level and liver metastasis.

Conclusions:

We found the baseline T3 level was associated with both prognosis and the response to ICIs in patients with advanced NSCLC, probably reflecting impaired liver function and systemic inflammation induced by the interaction of T3 with other biomarkers, such as IL-6, ACTH, cortisol, C-peptide, Hb, LDH, and albumin.
Realist evaluation of a transdisciplinary mealtime management service for autistic children
Authors: Chan Wai Ting , Chong Christina Li Ern , Goh Zhao Min , Ling Chrystal Xin Xuan , Tong Ruyi , Davey Madeline , Black Melissa H
Published: December 2022

Autistic children commonly experience mealtime difficulties; however, it is unknown what makes an effective transdisciplinary mealtime service for autistic children. This study used a realist evaluation framework to explore caregivers’ and therapists’ perceptions of the contexts, mechanisms and associated outcomes of a transdisciplinary mealtime management service for autistic children. Semi-structured interviews were conducted with six caregivers of autistic children engaged in a transdisciplinary mealtime service and 10 therapists providing the service, with interview data analysed using a realist evaluation approach. Four-context (child factors, family factors, therapist factors and institutional parameters), three-mechanism (transdisciplinary collaboration, child-centred approach and managing caregiver expectations) and two-outcome (impact on the child and impact on the caregiver) themes were identified. Findings highlighted that transdisciplinary collaboration, a child- and family-centred approach and managing caregiver expectations are key mechanisms providing a foundation for the development of evidence-based mealtime services for autistic children.

Lay abstract

Mealtimes and eating can be difficult for autistic children. A service where different professions work together is required to address the varied and complex mealtime difficulties of autistic children. Little is known about what is needed for such services to be effective. We interviewed six caregivers of autistic children who were engaged in a mealtime service and 10 therapists who are involved in delivering the service to understand their perspectives on the factors that were driving the effectiveness of the mealtime service. We found that different health professionals from different disciplines working together, focusing on adapting intervention to the child and family and managing expectations of the caregiver were important in contributing to outcomes of the mealtime service. The findings of this study can be used to inform the development of more effective interventions and services to support the well-being and development of autistic children.
Implementing NIH Behavior Change Consortium Treatment Fidelity Recommendations in a Multi-Site Randomized Controlled Trial of an Active Music Engagement Intervention for Young Children with Cancer and Parents
Authors: MacLean Jessica A. , Stegenga Kristin A. , Henley Amanda K. , Robb Sheri L.
Published: December 2022

Treatment fidelity is the use of methodological strategies to monitor and enhance reliability and validity of behavioral intervention trials. Despite availability of guidelines and checklists, treatment fidelity remains underreported, hindering evaluation, interpretation, and cross-study comparisons. Treatment fidelity is particularly important for music interventions given the inherent complexity of musical stimuli and flexibility required for tailored delivery. The purpose of this paper is to define and describe treatment fidelity strategies for our trial of a music-based play intervention for young children with cancer and parents grounded in the NIH Behavior Change Consortium Treatment Fidelity Recommendations. We report strategies for all 5 areas: study design, training providers, delivery of treatment, receipt of treatment, and enactment of treatment skills. We also discuss 4 challenges our team encountered, including: (1) standardizing live music delivery, (2) defining boundaries for tailored intervention delivery, (3) managing extended time between participants, and (4) minimizing risk for bias. This paper expands on current fidelity literature and may provide a working model for other investigators examining dyadic and/or active music interventions.
Clinical Delivery and Effectiveness of Music Therapy in Hematology and Oncology: An EMMPIRE Retrospective Study
Authors: Rodgers-Melnick Samuel N. , Rivard Rachael L. , Block Seneca , Dusek Jeffery A.
Published: December 2022

Background:

Music therapy (MT) has been shown to improve outcomes for patients with sickle cell disease (SCD) and patients with hematologic and/or oncologic conditions excluding SCD (HemOnc) in prior randomized trials. While few studies have described the clinical delivery (ie, volume, clinical settings, patient characteristics, referrals, and session characteristics) of MT and examined its real-world effectiveness, no studies have compared responses between hematology/oncology populations. The purpose of this study was to examine the clinical delivery and effectiveness of MT at a freestanding academic cancer center and compare the effectiveness of MT on pain, anxiety, and fatigue between adult patients in the HemOnc and SCD groups.

Methods:

A retrospective review was conducted of all MT sessions provided at a freestanding academic cancer center between January 2017 and July 2020. The unadjusted single-session effects of MT on pain, anxiety, and fatigue were assessed among patients reporting symptoms ≥1 out of 10 on a 0 to 10 scale. Adjustments were made for multiple sessions on the same patient using a mixed model to compare pre-session and change scores between the HemOnc and SCD groups. Patients’ comments were analyzed using conventional qualitative content analysis.

Results:

Music therapists provided 4002 sessions to 1152 patients including 1012 in the HemOnc group and 140 in the SCD group. In the combined sample, statistically significant reductions in pain (1.48 units), anxiety (2.58 units), and fatigue (0.84 units) were observed, with changes in pain and anxiety exceeding clinically significant thresholds. After adjustment, the SCD group reported significantly greater pre-session pain (7.22 vs 5.81) and anxiety (6.11 vs 5.17) as well as greater anxiety reduction (2.89 vs 2.23) than the HemOnc group. Patients’ comments contained themes including enjoyment, gratitude, and improvements in mood, pain, and anxiety.

Conclusions:

This study supports the delivery and clinical effectiveness of MT for addressing the needs of patients throughout their course of treatment at an academic cancer center and justifies the inclusion of individuals with SCD within integrative oncology services.
Analysis of scRNA-seq and bulk RNA-seq demonstrates the effects of EVI2B or CD361 on CD8+ T cells in osteosarcoma
Authors: Xie Tianyu , Feng Wenyu , He Mingwei , Zhan Xinli , Liao Shijie , He Juliang , Qin Zhaojie , Li Feicui , Xu Jiake , Liu Yun , Wei Qingjun
Published: December 2022

Osteosarcoma (OS) is a common primary malignant tumor of the bone in children and adolescents. The five-year survival rate is estimated to be ~70% based on the currently available treatment modalities. It is well known that tumor-infiltrating immune cells (TIICs) that are the most important components in the tumor microenvironment can exert a killing effect on tumor cells. Therefore, in the present study, 85 RNA-sequencing OS samples were categorized into high- and low-immune score groups with ESTIAMATE. Based on the immune score groups, 474 differentially expressed genes (DEGs) were acquired using the LIMMA package of R language. Subsequently, 86 DEGs were taken through univariate COX regression analysis, of which 14 were screened out by least absolute shrinkage and selection operator regression analysis. Furthermore, multivariate COX regression analysis was performed to obtain 4 DEGs. Finally, ecotropic virus integration site 2B (EVI2B) or CD361 gene was screened out via Kaplan-Meier analysis. In addition, CIBERSORT algorithm was used to evaluate the proportion of 22 kinds of TIICs in OS. Correlation analysis revealed that the high expression level of EVI2B can elevate the infiltrated proportion of CD8+ T cells. Moreover, analysis of single cell RNA-sequencing transcriptome datasets and immunohistochemical staining uncovered that EVI2B was mainly expressed on CD8+ T cells and that EVI2B could promote the expression of granzyme A and K of CD8+ T cells to exhibit a potent killing effect on tumor cells. Therefore, EVI2B was identified as a protective immune-related gene and contributed to good prognosis in OS patients.
Electroacupuncture ameliorates knee osteoarthritis in rats via inhibiting NLRP3 inflammasome and reducing pyroptosis
Authors: Zhang Wei , Zhang Lelei , Yang Shuo , Wen Bin , Chen Juan , Chang Jun
Published: December 2022

Objective: Knee Osteoarthritis (KOA), is the most common joint disease worldwide. The pathogenesis of KOA is complex and electroacupuncture (EA) is an effective therapy for KOA, but the mechanism remains unclear. In this study, we aim to investigate the potential therapeutic effect of EA on the rat model of KOA induced by monosodium iodoacetate (MIA) and its relationship with NLRP3 inflammasome by immunohistochemistry and western blot. Methods: KOA was induced by intra-articular injection of MIA (3 mg/50 μL) into the right knee joint of rats. Forty-five male rats weighing 250–300 g were randomly divided into 3 groups: control group, KOA group, and KOA + electroacupuncture group (KOA+EA). EA treatment lasted for 2 weeks (6 times a week). Paw withdrawal threshold tests were used to assess mechanical allodynia once a week. Safranin O/Fast Green and hematoxylin and eosin (H&E) staining were used to assess the damage to cartilage, synovium, and subpatellar fat pad (IFP). Immunohistochemistry was used to observe NLRP3 inflammasome-associated protein-positive cells in the same field of view and western blot was used to detect the expression of the associated protein in cartilage tissue. Results: The KOA group showed mechanical hyperalgesia, joint inflammation, and significant cartilage tissue destruction. Safranin O/Fast Green and H&E staining revealed that EA alleviated the joint pathological changes caused by KOA and had a protective effect on cartilage, synovium, and IFP destruction. Mechanical allodynia pain and joint swelling were reduced in KOA rats after EA treatment. Immunohistochemistry and western blot showed significant inhibition of NLRP3 inflammasome-associated protein. Conclusion: The results indicate that EA can inhibit NLRP3 inflammasome and reduce pyroptosis, which results in the protection of cartilage tissue and the treatment of KOA. It provides reliable evidence for the development of EA in the treatment of KOA and the clinical application of acupuncture.
Social media use, mental health, and suicide-related outcomes in Russian women: A cross-sectional comparison between two age groups
Authors: Brailovskaia Julia , Krasavtseva Yulia , Kochetkov Yakov , Tour Polina , Margraf Jürgen
Published: December 2022

Background:

Women who belong to the age group “emerging adulthood” (18 to 29 years) are vulnerable to mental health issues and suicide-related outcomes.

Objectives:

This study investigated potential predictors of suicide-related outcomes in females emerging adulthood and compared them to older women.

Design and Methods:

Data of 2537 women from Russia (group “18 to 29 years”: n = 1123; group “> 29 years”: n = 1414) on lifetime suicide-related outcomes, (problematic) social media use, daily stress, depression and anxiety symptoms, and positive mental health were assessed via online cross-sectional surveys.

Results:

The younger group spent significantly more time on social media use than the older group. It had significantly higher levels of daily stress, problematic social media use, depression and anxiety symptoms, and suicide-related outcomes. The older group showed significantly higher levels of positive mental health. Only in the younger group, problematic social media use significantly mediated the relationship between daily stress and suicide-related outcomes in a moderated mediation analysis. Positive mental health significantly moderated the association between problematic social media use and suicide-related outcomes. Specifically, the higher the positive mental health level, the less close the link between both variables.

Conclusion:

The current results reveal that young women in Russia could be at enhanced risk for daily stress, problematic social media use, and low levels of mental health. The interaction between these variables could foster suicide-related outcomes. Public governmental communication in Russia should call attention to potential negative impact of intensive social media use.
Government public relations, audiovisual communication and the informalisation of Sweden
Authors: Stjernholm Emil
Published: December 2022

This article addresses the role of television as a ‘new media’ in government public relations. Drawing on sociological theories on informalisation, this study analyses three features of the Swedish public information programme Anslagstavlan during the 1970s and 1980s: first, formal techniques such as editing, pacing and use of animations; second, narrative strategies including the utilisation of celebrity advertising and intertextuality; and last, the rhetoric of public information. The study shows that the engineering of informality was a key communication strategy for government agencies and that televised information contributed to the conversationalisation and personalisation of government agencies’ communication in medium-specific ways.
Biomechanical Effects of Surgical Reconstruction for Flexible Progressive Collapsing Foot Deformity: A Systematic Review
Authors: Estes William , Syal Amit , Latt L. Daniel
Published: December 2022

Background

Symptomatic progressive collapsing foot deformity (PCFD) is frequently treated with reconstructive surgery. Multiple studies have documented successful treatment based on improvements in symptoms and physical examination findings. However, it is not well-established whether there are corresponding improvements in gait function following surgical treatment for PCFD.

Methods

A systematic review of biomechanical outcomes of treatments for flexible PCFD was conducted on PubMed. The 4 articles chosen involved patients with symptomatic flexible PCFD who underwent a reconstructive surgery. Surgical interventions included osteotomy, tendon transfer, and/or ligament repair or reconstruction. Primary outcomes involved objective quantifiable measurements of kinematic, kinetic, or temporospatial parameters.

Results

The initial search yielded 605 articles, from which 26 were retained after screening the title and abstract. Twenty-two were eliminated yielding 4 articles. Temporospatial, kinematic, and kinetic parameters were all altered after the patients underwent surgical intervention. Specifically, stride length, cadence, and walking speed all improved postoperatively. Walking kinetics also improved with restoration of normal motion in the frontal and sagittal planes and improvements in the dorsiflexion angle. There were also improvements in sagittal power.

Discussion

Surgical intervention to treat flexible PCFD improves objective biomechanical outcomes; however, more follow-up studies are needed to establish the reliability and durability of these improvements.

Level of Evidence:

Level III: Systematic review
Healthcare-seeking delay during COVID-19 pandemic among tuberculosis patients in Ilubabor zone health facilities, south-west Ethiopia
Authors: Feyisa Jira Wakoya , Kitila Keno Melkamu , Lemu Jiregna Chalchisa , Hunde Megersa Dinku , Hunde Aboma Diriba
Published: December 2022

Introduction:

Fear of COVID-19 makes tuberculosis (TB) patients seek health care after complications of the case. This can be the reason for serious illness, increased length of infectiousness, poor treatment outcomes, and economic crisis for families and the health system. Despite this, no study has been conducted in Ethiopia and in other African countries with the factor “fear of COVID-19.” Identified preventable factor and other covariates are used to reduce the healthcare-seeking delay.

Objective:

This study assessed the association of fear of COVID-19 with healthcare-seeking delay among TB patients in Ilu Ababor Zone health facilities, south-western Ethiopia.

Methods and materials:

A health institution-based cross-sectional study was conducted among TB patients from October 15, 2020, to March 1, 2021. Using a systematic sampling method, 403 TB patients were selected for face-to-face interviews. The association of fear of getting COVID-19 with healthcare-seeking delay was assessed by a chi-square test. Variables with a p-value <0.25 in the bi-variable binary logistic regression were entered into the multivariable binary logistic regression model. The level of statistical significance in multivariable binary logistic regression was declared at a p-value <0.05.

Result:

In this study, the proportion of patient healthcare-seeking delay was 46.7%. Chi-square test of the association of fear of COVID-19 with healthcare-seeking delay among TB patients showed a significant association ( p-value = 0.042). After controlling for covariates, patients living in rural area (adjusted odds ratio (AOR) = 2.437, 95% confidence interval (CI): 1.385–4.286), patients with poor knowledge (AOR = 3.300, 95% CI: 1.792–6.078), earning monthly income <200 Ethiopian birr (ETB) (AOR = 3.912 95% CI: 1.951–7.841), traveling greater than 30 min (AOR = 2.127, 95% CI: 1.301–3.476), and fear of COVID-19 pandemic (AOR = 3.124, 95% CI: 1.029–9.479) were significantly associated with patient healthcare-seeking delay.

Conclusion:

The study found that healthcare-seeking delay among TB patients was substantial. Patient healthcare-seeking delay was significantly associated with fear of COVID-19.
Neglected wooden foreign body in the parotid gland: A case report
Authors: Neeraj KC , Dubey Tulika , Shakya Dipesh
Published: December 2022

Foreign body anywhere in the body can be a diagnostic challenge to a doctor, especially if it is wooden and hardly symptomatic. A foreign body in the parotid gland, whether from the oral cavity or through the skin is extremely uncommon. We are presenting a case of a wooden foreign body in the parotid gland of a 61-year-old patient who did not want to be examined or treated initially as it was not causing him any troublesome symptoms.
A 6-year-old child with a new diagnosis of perinatal human immunodeficiency virus infection
Authors: Valencia Deray Kristen G , Weyland Cassie , Jeang Diana , Mirani Gayatri , Cameron Lindsay H
Published: December 2022

Perinatal human immunodeficiency virus transmission, while rare in the United States, should be considered in children with a history of recurrent infections, chronic respiratory symptoms and developmental delay. A delayed diagnosis of human immunodeficiency virus in children can lead to significant morbidity and mortality. We present a 6-year-old male who presented for evaluation and management of antibiotic refractory chronic cough and purulent nasal secretions, with a history of recurrent bacterial pneumonias and sinus infections, disseminated varicella zoster, and global developmental delay. He likely had perinatally acquired human immunodeficiency virus. At the time of his human immunodeficiency virus diagnosis, he met the criteria for acquired immunodeficiency syndrome and was ultimately diagnosed with lymphocytic interstitial pneumonia (LIP). Our case illustrates the importance of universal human immunodeficiency virus screening of pregnant women, consideration of human immunodeficiency virus, and the prompt initiation of treatment. We believe this case serves as an important reminder for all medical providers who care for pregnant women and children.
The East Gotland Basin (Baltic Sea) as a candidate Global boundary Stratotype Section and Point for the Anthropocene series
Authors: Kaiser Jérôme , Abel Serena , Arz Helge W , Cundy Andrew B , Dellwig Olaf , Gaca Pawel , Gerdts Gunnar , Hajdas Irka , Labrenz Matthias , Milton James A , Moros Matthias , Primpke Sebastian , Roberts Sarah L , Rose Neil L , Turner Simon D , Voss Maren , Ivar do Sul Juliana A
Published: December 2022

The short sediment core EMB201/7-4 retrieved from the East Gotland Basin, central Baltic Sea, is explored here as a candidate to host the stratigraphical basis for the Anthropocene series and its equivalent Anthropocene epoch, still to be formalized in the Geological Time Scale. The core has been accurately dated back to 1840 CE using a well-established event stratigraphy approach. A pronounced and significant change occurs at 26.5 cm (dated 1956 ± 4 CE) for a range of geochemical markers including 239+240Pu, 241Am, fly-ash particles, DDT (organochlorine insecticide), total organic carbon, and bulk organic carbon stable isotopes. This stratigraphic level, which corresponds to a change in both lithology and sediment colour related to early anthropogenic-triggered eutrophication of the central Baltic Sea, is proposed as a Global boundary Stratotype Section and Point for the Anthropocene series.
“The pandemic has added to my miseries”: Bangladeshi migrant workers’ social protection revisited
Authors: Rashid Syeda Rozana , Ansar Anas , Md. Khaled Abu Faisal
Published: December 2022

The protection of migrant workers has received renewed attention in the wake of the COVID-19 pandemic. This article depicts how unpreparedness, inadequate social security and support services, and pre-existing socio-economic disparities disproportionately impacted Bangladeshi migrant workers during the pandemic. Adopting a qualitative approach based on findings from existing literature and surveys and primary data collected through interviews with returnee Bangladeshi migrants from the Gulf States, the article argues that the dearth of institutional, legal, social, and political understanding of the needs of migrants remains the main impediment to a comprehensive social protection system. The findings call for designing a crisis response and recovery policy, preparing a returnee database and leveraging bilateral, regional, and global processes to ensure migrants’ uninterrupted protection at home and abroad. The article also underscores the importance of a nuanced understanding and practice of gendered social support, and above all, adopting a rights-based approach to labor migration.
Enhancing Student Authorship and Broadening Personal Latitude in the Mathematics Classroom With Rich Dialogic Discourse
Authors: Cheng (郑永健) Wing Kin , Ng (吴蔼蓝) Oi-Lam , Ni (倪玉菁) Yujing
Published: December 2022

Purpose

In this article, we explore how student authorship may be enhanced among learners in mathematics classrooms in a Hong Kong primary school through rich dialogue discourse.

Design/Approach/Methods

Using qualitative methods, that is, coding and discourse analysis, we examine the relationship between student authorship and personal latitude through a case study of two Grade 4 mathematics lessons taught by two primary mathematics teachers, respectively.

Findings

We discuss the study's findings in relation to how teachers can engage themselves and their students in dialogic discourse to offer student choices and opportunities and generate original voices.

Originality/Value

Personal latitude was found when the students were given the choice to use their original voices. The learners assumed the role of author; consequently, authorship was enhanced in ensuing rich dialogic discourse.
Automated and Human Interaction in Written Discourse: A Contrastive Parallel Corpus-based Investigation of Metadiscourse Features in Machine-Human Translations
Authors: Afzaal Muhammad , Imran Muhammad , Du Xiangtao , Almusharraf Norah
Published: December 2022

The rise of the internet has generated a need for fast online translations, which human translators cannot meet. Statistical tools such as Google and Baidu Translate provide automatic translation from one written language to another. This study reports the descriptive comparison of the machine-translation (MT) with human translation (HT), considering the metadiscoursal interactional features. The study uses a parallel corpus consisting of 79 texts translated from Chinese to English by professional human translators and machine translations (Baidu translate & Google translate) and a comparable reference corpus of non-translated English text. The statistical analysis revealed no statistically significant difference between Baidu and Google translate regarding all types of metadiscoursal indicators. However, the findings of this study demonstrate significant disparities in the interactional characteristics of various HT and MT groups. Compared to the metadiscourse features in non-translated English political texts, human translators were found to outperform machine translations in the use of attitude markers. In contrast, the distribution of directives in machine-translated texts is more native-like. In addition, MT and HT have utilized a significantly smaller number of hedges, self-mention, and readers than non-translated texts. Our results indicate that the MT systems, though still calling for further improvement, have shown tremendous growth potential and may complement human translators.
The effect and safety of periarticular multimodal drug injection without morphine and epinephrine in anterior cruciate ligament reconstruction
Authors: Han Changhun , Hashimoto Yusuke , Nakagawa Sunao , Takahashi Shinji , Nishida Yohei , Yamasaki Shinya , Takigami Junsei , Nakamura Hiroaki
Published: December 2022

Background

Periarticular multimodal drug injection (PMDI) is a safe and effective pain management technique after anterior cruciate ligament reconstruction (ACLR); however, adding morphine and epinephrine sometimes causes adverse effects. Therefore, we evaluated the efficacy of PMDI without morphine and epinephrine after ACLR.

Methods

This retrospective matched case-control study included patients who had undergone primary double-bundle ACLR with PMDI and were then matched one-to-one with a control group without PMDI based on sex, age, and body mass index using propensity-matched analysis. The following clinical outcomes were compared between the groups: visual analog scale (VAS) score, C-reactive protein (CRP) concentration, number of times the patients used additional analgesics, complication rate, and postoperative time to achieve straight leg raise (SLR).

Results

Twenty-nine patients with PMDI and 29 controls were enrolled. The VAS score at 1 day postoperatively was lower in the PMDI than the control group (1.93  ±  1.44 vs. 3.41  ±  1.75, respectively; P < 0.001). The CRP concentration at 1 and 3 days was lower in the PMDI than the control group (0.46  ±  0.47 vs. 1.00  ±  0.69 mg/dL, P < 0.001; and 1.93  ±  1.71 vs. 4.01  ±  2.55 mg/dL, P < 0.001, respectively). The average number of additional analgesics used was significantly lower in the PMDI than the control group. There were no significant differences in the frequency of occurrence of postoperative complications between the two groups. The number of patients who could achieve SLR within 1 day was 27/29 (93%) in PMDI group, which was significantly higher than the control group (12/29, 41%) ( P < 0.001).

Conclusion

PMDI without morphine and epinephrine after ACLR reduced patients’ subjective pain level, objective inflammatory response without complications and enabled patients to achieve early functional recovery.
National Education Policy 2020 and Challenges to the Bar Council of India
Authors: Mitra N. L. , Sinha Manoj Kumar
Published: December 2022

Every field of higher education, including the arts, social sciences, physical sciences, technology, and law, as well as every form of education, whether general, professional, or technical, has something to ‘take’ from the National Education Policy (NEP) 2020. This is the first time in the history of the National Education Policy that legal education is referenced within the context of higher education. All stand-alone universities, such as National Law Universities, must be turned into multidisciplinary universities under Policy 2020. By 2030, all institutions that provide professional or general education will strive to organically evolve into institutions that provide both fluidly and integrated manner. The Policy called for the complete abolition of the affiliation system and the conversion of affiliated institutions into either constituent colleges of the university under the direct management and control of the university or autonomous multidisciplinary degree conferring colleges, or for a few affiliated colleges to be bundled together through mergers and acquisitions and then converted into either autonomous institutions or universities, and affiliated colleges in phase manner will be converted into autonomous colleges. Under the NEP 2020, there will be a single regulatory structure for all forms of education, with the exception of medical and legal education. However, the Policy did not establish or mention a distinct regulator for law and medicine. Whereas the National Medical Commission (NMC), the successor to the Medical Council of India, was established to regulate medical education, the Bar Council of India (BCI) was established by the Advocates Act solely to establish a professional body for practising advocates (Bar Council of India and States). If the BCI is to function as a regulatory body for legal education, it must walk a mile in order to implement the NEP 2020 for all stages of legal education, undergraduate, postgraduate, and research studies, as well as for all types of education, academic, professional, and clinical skill learning. Assuming that the deadline specified in the NEP 2020 is final and that a new shape of education is required under the NEP, BCI will need to emphasize what needs to be done and then how such changes in all levels can be accomplished within the timeframe!
Social Exclusion and Education: Analysing the Rights of Dalit Children Through the Lens of Democracy and Citizenship
Authors: Singh Vikram , Sharma Kabir
Published: December 2022

The educational concerns of the Dalit community must be addressed from a perspective of social justice, as the Dalit community has historically been subject to social discrimination and restricted access to education. ‘The social justice framework is significant because it emphasises worries about the meaning of one’s education on one’s sense of self and one’s prospects for the future, as opposed to focusing solely on concerns about educational equity, including issues of access, participation, and outcomes. It also sheds light on the pledges made by educational institutions to the most vulnerable people and how these promises are carried out in practice’ (Nambissian, 2006). The children of Dalit community have in the contemporary context come under analysis across the world. They always faced social exclusion by the majority, the state and its institutions; still, the strong law pertains. This has hampered their growth and development. In countries such as India, the social exclusion of Dalits is also a concern. Therefore, this article attempts to describe, in broad terms, Societies’ manifest behaviours and tendencies that exclude (i.e., exclusion as a citizen in a democratic country) those deemed undesirable or useless from the predominate systems of protection and integration, thereby limiting their opportunities and means of survival. It also attempts to investigate the educational disadvantages of Dalit children in India. It looks at social exclusion, concerning the idea of democracy and citizenship. Furthermore, it explains the development and use of the concept of social exclusion in the Indian context concerning Dalit children and how it is also a helpful policy concept for the integration of various philosophical conceptions like equality, justice, and emancipation on the primary purpose of the welfare state into a single social model. Lastly, it examines the impact of social exclusion in elementary education and its impact on the educational and social conditions of Dalit children in India.
Statistical assessment of the prognostic and the predictive value of biomarkers-A biomarker assessment framework with applications to traumatic brain injury biomarker studies
Authors: Bantis Leonidas E , Young Kate J , Tsimikas John V , Mosier Brian R , Gajewski Byron , Yeatts Sharon , Martin Renee L , Barsan William , Silbergleit Robert , Rockswold Gaylan , Korley Frederick K
Published: December 2022

Studies that investigate the performance of prognostic and predictive biomarkers are commonplace in medicine. Evaluating the performance of biomarkers is challenging in traumatic brain injury (TBI) and other conditions when both the time factor (i.e. time from injury to biomarker measurement) and different levels or doses of treatments are in play. Such factors need to be accounted for when assessing the biomarker’s performance in relation to a clinical outcome. The Hyperbaric Oxygen in Brain Injury Treatment (HOBIT) trial, a phase II randomized control clinical trial seeks to determine the dose of hyperbaric oxygen therapy (HBOT) for treating severe TBI that has the highest likelihood of demonstrating efficacy in a phase III trial. Hyperbaric Oxygen in Brain Injury Treatment will study up to 200 participants with severe TBI. This paper discusses the statistical approaches to assess the prognostic and predictive performance of the biomarkers studied in this trial, where prognosis refers to the association between a biomarker and the clinical outcome while the predictiveness refers to the ability of the biomarker to identify patient subgroups that benefit from therapy. Analyses based on initial biomarker levels accounting for different levels of HBOT and other baseline clinical characteristics, and analyses of longitudinal changes in biomarker levels are discussed from a statistical point of view. Methods for combining biomarkers that are of complementary nature are also considered and the relevant algorithms are illustrated in detail along with an extensive simulation study that assesses the performance of the statistical methods. Even though the discussed approaches are motivated by the HOBIT trial, their applications are broader. They can be applied in studies assessing the predictiveness and prognostic ability of biomarkers in relation to a well-defined therapeutic intervention and clinical outcome.
Collective decision-making under changing social environments among agents adapted to sparse connectivity
Authors: Mann Richard P
Published: December 2022

Humans and other animals often follow the decisions made by others because these are indicative of the quality of possible choices, resulting in ‘social response rules’, that is, observed relationships between the probability that an agent will make a specific choice and the decisions other individuals have made. The form of social responses can be understood by considering the behaviour of rational agents that seek to maximise their expected utility using both social and private information. Previous derivations of social responses assume that agents observe all others within a group, but real interaction networks are often characterised by sparse connectivity. Here, I analyse the observable behaviour of rational agents that attend to the decisions made by a subset of others in the group. This reveals an adaptive strategy in sparsely connected networks based on highly simplified social information, that is, the difference in the observed number of agents choosing each option. Where agents employ this strategy, collective outcomes and decision-making efficacy are controlled by the social connectivity at the time of the decision, rather than that to which the agents are accustomed, providing an important caveat for sociality observed in the laboratory and suggesting a basis for the social dynamics of highly connected online communities.
Eosinophilic granulomatosis with polyangiitis: case report and literature review
Authors: Alam Vardah , Nanzer Alexandra M.
Published: December 2022

Eosinophilic granulomatosis with polyangiitis (EGPA), previously known as Churg–Strauss syndrome, is a multisystem disorder characterised by asthma, blood and tissue eosinophilia and small-vessel vasculitis. Eosinophilic tissue infiltration and extravascular granuloma formation can lead to damage in any organ, but it is classically seen to cause pulmonary infiltrates, sino-nasal disease, peripheral neuropathy, renal and cardiac involvement, and rashes.

EGPA is part of the anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis syndromes, with the antibody being detected in ∼30–40% of cases and mostly against myeloperoxidase. Two genetically and clinically distinct phenotypes, defined by the presence or absence of ANCA have been identified. Treatment for EGPA focuses on inducing and maintaining disease remission. To date, oral corticosteroids remain first-line agents whilst second-line treatments include immunosuppressants such as cyclophosphamide, azathioprine, methotrexate, rituximab and mycophenolate mofetil. However, long-term steroid usage results in multiple and well-known adverse health effects and new insights into the pathophysiology of EGPA have allowed for the development of targeted biologic therapies, like the anti-eosinophilic, anti-interleukin-5 monoclonal antibodies.
Cell size, body size and Peto’s paradox
Authors: Maciak Sebastian
Published: December 2022

Carcinogenesis is one of the leading health concerns afflicting presumably every single animal species, including humans. Currently, cancer research expands considerably beyond medicine, becoming a focus in other branches of natural science. Accumulating evidence suggests that a proportional scale of tumor deaths involves domestic and wild animals and poses economical or conservation threats to many species. Therefore, understanding the genetic and physiological mechanisms of cancer initiation and its progression is essential for our future action and contingent prevention. From this perspective, I used an evolutionary-based approach to re-evaluate the baseline for debate around Peto’s paradox. First, I review the background of information on which current understanding of Peto’s paradox and evolutionary concept of carcinogenesis have been founded. The weak points and limitations of theoretical modeling or indirect reasoning in studies based on intraspecific, comparative studies of carcinogenesis are highlighted. This is then followed by detail discussion of an effect of the body mass in cancer research and the importance of cell size in consideration of body architecture; also, I note to the ambiguity around cell size invariance hypothesis and hard data for variability of cell size across species are provided. Finally, I point to the new research area that is driving concepts to identify exact molecular mechanisms promoting the process of tumorigenesis, which in turn may provide a proximate explanation of Peto’s paradox. The novelty of the approach proposed therein lies in intraspecies testing of the effect of differentiation of cell size/number on the probability of carcinogenesis while controlling for the confounding effect of body mass/size.