bluuebunny/crossref_metadata_2025 huggingface dataset:
Recommendations on the certification of reference standards for structure identification of recombinant therapeutic proteins
Authors: Ustinnikova O. B. , Volkova R. A. , Movsesyants A. A. , Merkulov V. A. , Bondarev V. P.
Published: July 2022

Reference standards for structure identification of recombinant therapeutic proteins are essential for quality assessment of recombinant protein-based biotechnological medicinal products. The development and certification of such reference standards hold special relevance because of, firstly, the absence of international, national or compendial reference standards for a number of new or recently approved proteins and, secondly, the disruption of supply chains providing the biopharmaceutical industry of the Russian Federation with international reference standards. Moreover, international and national regulatory documents contain only general requirements for the procedure of reference standards certification but not the considerations specific to the standards for biotechnologicals’ structure identification, which vary with the production technologies for each individual active moiety. The aim of this work was to provide recommendations on the procedure for the development and certification of reference standards used to identify the structure of recombinant therapeutic proteins. These recommendations define 4 main stages of the procedure: stage 1 covers the development of requirements for the reference standard, including the justification of material and formulation choices, the elaboration of quality specifications, and the assessment of quality; stage 2 comprises the selection of analytical procedures and the establishment of the values for the certified parameters; stage 3 includes stability studies and shelf-life setting; and stage 4 involves the development of documentation for the reference standard. The paper dwells upon the scope of the stages, taking into account the specific considerations for recombinant therapeutic proteins and the use of reference standards. The recommendations are based upon the extensive experience in biotechnologicals testing and standardisation of the employees of the Scientific Centre for Expert Evaluation of Medicinal Products. These recommendations can provide a base for the establishment of protein-specific certification programmes for reference standards used in structure identification. This approach will allow for systematisation of the process for standards development and ensure the traceability of information and the validity of results. The reference standards certified in accordance with these recommendations can be considered primary standards, if necessary.
Evaluation of the Efficacy and Safety of Initial Empirical Antibiotic Therapy for Community-Acquired Pneumonia in Middle-Aged People
Authors: Alexandrova T. V. , Muslimova O. V. , Zhuravleva M. V. , Alexandrov A. A. , Gorodetskaya G. I. , Demchenkova E. Yu. , Demidova O. A. , Sokova E. A. , Mazerkina I. A. , Smirnova Yu. А.
Published: July 2022

β-lactam antibiotics, including cephalosporins, are the drugs of choice for empirical antibiotic therapy (ABT) in patients with community-acquired pneumonia. Unreasonable and irrational use of antibiotics leads to an increased risk of adverse reactions, contributes to the growth of antibiotic resistance.

The aim of the study was to analyse data on the efficacy and safety of initial empirical ABT using cephalosporins for community-acquired pneumonia in middle-aged patients of multidisciplinary hospitals in Moscow.

Materials and methods: the authors analysed 177 archived medical records of the patients admitted to three multidisciplinary hospitals (I.V. Davydovsky City Clinical Hospital, City Clinical Hospital 52 and City Clinical Hospital 4) in Moscow from 2017 to 2019 and prescribed mono- and/or combination therapy including a cephalosporin antibiotic as a starting therapy for community-acquired pneumonia. The initial ABT was considered effective if a patient’s body temperature normalised within 48–72 h following initiation of treatment and safe if no adverse reactions developed during the period of inpatient treatment.

Results: the combination of ceftriaxone and azithromycin was the most frequently prescribed ABT regimen; its effectiveness was 71.9%. Ceftriaxone monotherapy was the second in frequency of prescription; its effectiveness amounted to 77.2%. The third regimen included cefotaxime and azithromycin and was effective in 70% of cases. The patients who needed a change in initial ABT had a significantly higher incidence of developing severe community-acquired pneumonia and complications. The study results indicate that the structure of comorbidity did not affect the effectiveness of initial empirical ABT. Streptococcus pneumoniae was found to be the most common causative agent of community-acquired pneumonia in the studied population (44.8% of cases). Only 13% of the patients faced adverse reactions associated with the use of antibiotics as part of the initial empirical ABT; the most common were leukopenia and diarrhoea.

Сonclusions: the results of the study indicate the feasibility of mono- and/or combination ABT including a cephalosporin antibiotic as a starting empirical therapy for community-acquired pneumonia due to its effectiveness and favourable safety profile.
Therapeutic Drug Monitoring for Evaluation of the Efficacy and Safety of Vancomycin in Patients with Orthopaedic Infections
Authors: Tufanova O. S. , Kasimova A. R. , Bozhkova S. A.
Published: July 2022

Vancomycin is a drug of choice for the infections caused by methicillin-resistant strains of staphylococci. Its use requires individualised dosing and renal function monitoring.

The aim of the study was to evaluate, using therapeutic drug monitoring (TDM), the frequency of reaching target trough serum concentrations (TSCs) and the frequency of renal function impairment in orthopaedic infection patients receiving vancomycin therapy.

Materials and methods: the authors carried out a retrospective analysis of vancomycin TSC test results of 457 patients admitted to a purulent osteology department in 2019–2021. The results were grouped according to the number of TSC determination performed as part of TDM (tests 1, 2, and 3). Each of the 3 groups was further divided into 4 subgroups according to the TSCs of vancomycin: ≤9.9 µg/ml (extremely low), 10–14.9 µg/ml (recommended for mild infections), 15–19.9 µg/ml (recommended for bone and joint infections), ≥20 µg/ml (potentially toxic). The results obtained in each group were analysed separately.

Results: according to the 1st TDM test, only 9.6% of patients achieved the TSCs of vancomycin recommended for bone and joint infections. Extremely low TSCs, insufficient for treatment of the infections, were found in 64.8% of patients. According to the 2nd and 3rd TSC determinations, dose corrections decreased the percentage of patients with extremely low TSCs to 49.9% and 41.2%, respectively. Potentially toxic TSCs of vancomycin were detected in 48 (10.5%) patients, but renal dysfunction was observed only in 8 (1.75%) of them. The authors exemplify the use of TDM to control the efficacy and safety of vancomycin in patients with pronounced signs of renal function impairment by two clinical cases.

Conclusion: with a standard dose of vancomycin, the concentrations recommended for bone and joint infections were reached only in every tenth patient. There was a large percentage of patients with extremely low serum concentrations of the medicinal product (64.8%), but it decreased after dose adjustments. Monitoring of vancomycin concentrations allows for individualised dosing, efficacy control and significant reduction of the risk of adverse kidney reactions.
Experience of Using Therapeutic Drug Monitoring to Control the Safety of Vancomycin in Intensive Care Unit Patients with Sepsis
Authors: Prokofiev A. B. , Belkov S. A. , Kazakov R. E. , Berdnikova N. G. , Rodina T. A. , Melnikov E. S. , Danko A. A. , Voronova N. E. , Vafina R. Z. , Zavtoniev A. V. , Tsyganko D. V. , Demchenkova E. Yu.
Published: July 2022

Vancomycin is prescribed to patients in serious condition with infections caused by Gram-positive microorganisms; however, if the therapeutic plasma concentration of the medicinal product is exceeded, it can have a nephrotoxic effect.

The aim of the study was to demonstrate the possibility of using therapeutic drug monitoring (TDM) to reduce the risk of developing nephropathy in intensive care unit patients with sepsis.

Materials and methods: the study comprised a retrospective analysis of four clinical cases of patients with sepsis admitted to intensive care units of I.V. Davydovsky City Clinical Hospital in 2021 and treated with vancomycin. TDM of vancomycin plasma levels was performed by reverse-phase high-performance liquid chromatography with mass spectrometric detection.

Results: using the four cases of septic patients, the study demonstrated that vancomycin at adequate case-specific doses may result in plasma concentrations beyond the therapeutic range. TDM of vancomycin concentrations helped to prevent further deterioration of renal dysfunction in one septic patient having developed acute kidney injury and to control the achievement of therapeutic vancomycin concentrations or timely adjust the dose to that effect in the other three cases.

Conclusions: a timely correction of vancomycin dosing with plasma TDM allows for achieving high antimicrobial efficacy in patients with sepsis and minimising the nephrotoxic effect of the medicinal product. Studies of the feasibility of using TDM as a treatment personalisation tool for patients in serious condition will continue in the future.
Efficacy and Safety of Ascites Treatment in Liver Cirrhosis
Authors: Ignatenko G. A. , Kugler T. E. , Taradin G. G. , Rakitskaya I. V. , Kaluga A. A.
Published: July 2022

Cirrhosis is one of the major health problems worldwide; and ascites is often its first and foremost manifestation. Despite the advances in modern hepatology, the presence of ascites is associated with a poor prognosis and high mortality. The aim of the study was to analyse data on the efficacy and safety of ascites treatment options, taking into account the pathophysiology of the condition. The analysis of literature and international guidelines on ascites management showed that cirrhotic ascites is treated with medication or surgery that interfere with pathogenetic mechanisms underlying the condition. Treatment of uncomplicated ascites depends on the severity of clinical manifestations. Patients with grade 1 ascites do not require treatment. Therapy for grade 2–3 ascites is aimed at reducing sodium intake and promoting its excretion with diuretics. The effect of diuretics should be assessed by daily monitoring of body weight. Close monitoring of serum creatinine and electrolyte levels is necessary to avoid severe electrolyte imbalance and mitigate the risk of diuretic-associated acute kidney injury. Another medical option to increase diuresis is the use of vasoconstrictors. Large volume paracentesis is the treatment of choice for patients with grade 3 ascites and refractory ascites. The most dangerous complication of paracentesis is circulatory dysfunction, which is prevented by limiting the volume of fluid removed to 5–6 liters per procedure and using plasma substitutes. If paracentesis is ineffective, new minimally invasive methods of treatment should be considered: transjugular intrahepatic portosystemic shunting and automated low-flow ascitic fluid removal system. However, given the poor prognosis, all patients with refractory ascites should be considered candidates for liver transplantation, which is currently the only effective treatment. The efficacy and safety of therapy may be enhanced by a personalised approach to choosing the treatment for ascites in cirrhosis, as well as further investigation of means to mitigate adverse reactions to medication and minimally invasive surgery.
Evaluation of the Effect of Comorbidity on the Efficacy and Safety of β-Lactam Antibiotics in Patients with Community-Acquired Pneumonia
Authors: Muslimova O. V. , Sokova E. A. , Prokofiev A. B. , Zhuravleva M. V. , Shapchenko A. V. , Alexandrova T. V.
Published: July 2022

Lower respiratory tract infections, which include community-acquired pneumonia (CAP), are the most common cause of death among all infectious diseases. The presence of a comorbid pathology in a patient with CAP suggests a possibility of mutual influence and changes in the course of both the underlying disease and comorbidities, as well as changes in the effectiveness and safety of ongoing drug therapy. The aim of the study was to analyse literature data on the structure of comorbidity in CAP patients and its impact on the efficacy and safety of therapy with β-lactam antibiotics. It has been established that CAP most often occurs in patients with chronic obstructive pulmonary disease, cardiovascular diseases (ischemic heart disease, arterial hypertension, and chronic heart failure), cerebrovascular disease, chronic kidney disease, diabetes mellitus, bronchial asthma, leukemia, anemia, dementia, neurological disorders, and cancer. The most common causative agent of CAP, regardless of the patient’s age and comorbidity, is pneumococcus (Streptococcus pneumoniae), followed by intracellular pathogens (mycoplasmas, chlamydia) and Haemophilus influenzae, as well as respiratory viruses. With this in mind, the initial empiric therapy for CAP mainly includes β-lactam antibiotics, which are effective against pneumococcus. If patients with CAP have concomitant chronic diseases and conditions, the spectrum of pneumonia pathogens may differ from that in the general population and include rare pathogens and multidrug-resistant strains. The effectiveness of antibiotic therapy in such patients is reduced, which leads to a worsening of the course of both CAP and concomitant diseases. This patient population may require longer treatment with antibiotics, including β-lactams, or the use of antibiotics at doses that provide a higher minimum inhibitory concentration, which is associated with a high risk of adverse reactions and a decrease in the safety of antibiotic therapy.
Determination of the sampling rate of a random process
Authors:   Institute of Radioelectronics, service and diagnostics, 644077, Russia, Omsk, pr. Mira, 57, Veshkurtsev Y.M. , Titov D.A. ,   Omsk State Technical University, 644050, Russia, Omsk, pr. Mira, 11
Published: July 2022

Using an additional coefficient, the sampling rate obtained as a result of applying the Whittaker-Kotelnikov-Shannon theorem to a random process with many probabilistic characteristics is refined. The purpose of this paper is to determine the values of an additional coefficient, allowing to find the value of the sampling rate of a process while maintaining a given error of distortion of any of the set of probabilistic characteristics. A transcendental equation is proposed, the solution of which, using experimenta data from the study of the probabilistic characteristics of real sources of random processes, makes it possible to calculate the value of the additional coefficient. When calculating the value of the additional coefficient, it turns out different when the probabilistic characteristics of the process and the distortion errors vary. It has been established that the use of an additional coefficient greater than one does not violate the fundamentality of the Whittaker-Kotelnikov-Shannon theorem and allows one to reasonably choose the sampling rate of a random process without exceeding the specified error in the distortion of its probabilistic characteristics.
Новый водорастворимый ИК-фотосенсибилизатор в ряду бактериохлорофилла a
Authors: Суворов Никита Владимирович , Сапельников Максим Дмитриевич , Плотникова Екатерина Александровна , Морозова Наталья Борисовна , Плютинская Анна Дмитриевна , Панкратов Андрей Александрович , Грин Михаил Александрович , Филоненко Елена Вячеславовна
Published: July 2022

В настоящее время наиболее перспективными соединениями, используемыми в фотодинамической терапии, являются производные хлоринов и бактериохлоринов. Однако использование указанных фотосенсибилизаторов в клинической практике ограничено из-за их малой растворимости в биологических жидкостях. В настоящей работе был синтезирован водорастворимый конъюгат дипропоксибактериопурпуринимида (ДПБИ) с плюроником F-127. Было показано, что конъюгирование с полоксамером не влияет на физико-химические и фотофизические свойства исходного фотосенсибилизатора (ФС). В ходе биологических испытаний обнаружено, что полученный конъюгат обладает фотодинамическими и фармакокинетическими свойствами, аналогичными таковым у исходного пигмента. При изучении острой токсичности продемонстрированы преимущества полученного ФС, внутривенное введение которого в размере 10 терапевтических доз не вызывает гибели животных, в отличие от водной эмульсии ДПБИ.
Синтез и цитотоксическая активность новых производных азолотриазина при изучении на клеточных культурах
Authors: Хумаири Ахмед Хамид , Сперанский Дмитрий Леонидович , Садчикова Елена Владимировна
Published: July 2022

Работа посвящена синтезу и определению цитотоксической активности новых производных азоло[5,1-c][1,2,4]триазина с целью установления потенциальной возможности их использования в качестве противоопухолевых средств; в том числе — для химиотерапии рака молочной железы. Спектральные характеристики свидетельствуют о высокой чистоте полученных соединений и их стабильности при хранении. В исследовании определена цитотоксичность с помощью метилтетразолиевого теста в отношении клеток линий MCF-7 и CHO. Соединения использованы в конечных концентрациях от 0,25 до 10,0 мкмоль/л. Наиболее токсичными в отношении клеток MCF-7 оказались имидазо[5,1-c][1,2,4]триазины 5a и 5d с расчетной концентрацией половинного подавления пролиферации клеток IC50 ниже по сравнению с препаратом сравнения эпирубицином в несколько раз. В отношении нетрансформированных клеток линии CHO цитотоксичность всех новых тестированных соединений оказалась ниже эффектов эпирубицина; что дополнительно свидетельствует об их потенциальной перспективности. Полученные данные можно использовать как основу для выбора соединений 5a и 5d для дальнейшего изучения их генотоксических и метаболических свойств на клеточных моделях и лабораторных животных в качестве веществ с потенциальной противоопухолевой активностью.
Синтез гидрохлоридов 3,3-диметил- и 3,3-диэтил-замещённых амидов 2-(3,4-дигидроизохинолин-1-ил)-карбоновых кислот и их антиаритмическая, гемостатическая, антигельминтная и ларвицидная активности
Authors: Перетягин Дмитрий Алексеевич , Михайловский Александр Георгиевич , Рудакова Ирина Павловна , Старкова Алла Валентиновна
Published: July 2022

Реакцией Риттера 1-(3,4-диметоксифенил)-2-метил-пропанола-2 или 1-фенил-2-этил-бутанола-2 с 2-R-цианоацетамидами (R = Et, n-Pr, i-Pr, n-Bu, n-Am, i-Am) синтезированы соответствующие 3,3-диметил- и 3,3-диэтилзамещённые 2-R-(3,4-дигидроизохинолин-1-ил)-ацетамиды. Гидрохлориды полученных соединений были испытаны на антиаритмическую активность (хлоридкальциевая модель), 3 соединения из 10 показали антиаритмическую активность с максимальным антиаритмическим индексом (АИ) 3,9. В отношении свертываемости крови все соединения оказались гемостатиками, наиболее активное соединение повышает свертываемость крови на 37,9 %. По антигельминтной активности 8 соединений превосходят пирантел и 2 соединения — левамизол. Для 9 соединений обнаружен ларвицидный (инсектицидный) эффект, 2 из них уменьшали продолжительность жизни личинок до 10,6 и 10,4 мин, что превышает эффект диазинона (17 мин).
Разработка способа получения и гиполипидемическая активность липолитического фермента из семян чернушки посевной Nigella sativa
Authors: Худойбердиев Т. А. , Ощепкова Юлия Игоревна
Published: July 2022

С целью разработки безотходной технологии из семян чернушки посевной проведено выделение липолитического фермента после отжима масла. Для получения фермента с наибольшей липолитической активностью осуществлен подбор оптимального температурного режима (37 °C) и pH (10,5) извлечения, при этом липолитическая активность фермента составила 150000 ед/г. Сравнительное изучение липолитического фермента и Себелипазы альфа показало, что применение липолитического фермента при твиновой модели гиперлипидемии у крыс приводит к снижению концентрации общего холестерина на 19,6 %, что свидетельствует о целесообразности рассмотрения возможности его применения для улучшения процессов всасывания в желудочно-кишечном тракте.
Использование кондуктометрического метода в микробиологическом контроле вспомогательных материалов природного происхождения
Authors: Ананьева Елена Петровна , Богданова Ольга Юрьевна , Гурина Светлана Владимировна , Сибирцев Владимир Станиславович
Published: July 2022

Показатель «микробиологическая чистота» является важным критерием качества нестерильных лекарственных препаратов и вспомогательных материалов в фармацевтической промышленности. Импедансный кондуктометрический метод микробиологического анализа (ИКММА) основан на регистрации изменений импеданса (сопротивления переменному электрическому току) жидкой питательной среды, возникающих в результате жизнедеятельности в этой среде микроорганизмов, содержащихся в анализируемой пробе. Целью работы было определение возможности применения ИКММА для определения общего микробного числа (ОМЧ) аэробных микроорганизмов во вспомогательных материалах природного происхождения. В результате установлена сходимость результатов определения ОМЧ кондуктометрическим и фармакопейным двухслойным агаровым методами с коэффициентом корреляции 0,95, что позволяет рекомендовать кондуктометрический метод в качестве рутинного метода определения ОМЧ аэробных микроорганизмов при анализе микробиологической чистоты вспомогательных материалов, предназначенных для фармацевтического производства.
Влияние противоспаечного геля на выживаемость и развитие вторичных осложнений после контузионной травмы спинного мозга у крыс
Authors: Кирсанова Анастасия Юрьевна , Кубрак Надежда Владимировна
Published: July 2022

В эксперименте на 45 крысах линии Вистар оценивали влияние гиалуронсодержащего противоспаечного геля на основе карбоксиметилцеллюлозы на развитие осложнений, возникающих в результате спинномозговой травмы. У животных вызывали однотипную контузионную травму спинного мозга средней степени тяжести. Крысам опытной группы после травмы на твердую мозговую оболочку наносили 0,2 мл противоспаечного рассасывающегося геля «Антиадгезин», крысам контрольной группы дополнительных манипуляций не проводили. Локальное применение противоспаечного геля после травмирования спинного мозга позволило уменьшить тяжесть и частоту возникновения вторичных явлений: встречаемость урологических осложнений в группе с применением исследуемого препарата после травмы была ниже в 1,8 раза, по сравнению с контрольной групой, выявленные изменения мочевыделительной и других систем имели более лёгкое течение. Уровень смертности в результате возникших осложнений среди животных опытной группы был ниже в 4,8 раза в сравнении с контрольной (p < 0,05).
Нарушения обмена железа и пути их фармакологической коррекции
Authors: Миронов Сергей Евгеньевич , Горбунов Александр Анатольевич , Тихонов Дмитрий Александрович , Лемина Елена Юрьевна
Published: July 2022

Рассмотрены основные состояния, характеризующиеся нарушением обмена железа: анемии, гемохроматоз, воспалительные, аутоиммунные и нейродегенеративные заболевания, хроническая почечная недостаточность, инфекционные заболевания – COVID-19 и др. Охарактеризованы принципы их лекарственной коррекции и риски развития нежелательных побочных эффектов. Оценены потенциальные лекарственные мишени и возможные группы лекарственных препаратов: ингибиторы пролил-4-гидроксилазы, средства, снижающие активность морфогенетических протеинов кости (bone morphogenetic proteins 6, BMP 6), ферропортина и гепсидина, ингибиторы фактора, индуцируемого гипоксией (hypoxia-inducible factor, HIF-1α), и переносчика ионов двухвалентных металлов 1 (divalent metal transporter 1, DMT-1).
Qualitative Case Study of the Mothers’ Educational Practices for Children’s Academic Success: Korean Bear Mothers
Authors:   Korean Association for Qualitative Inquiry, Kim Gyeongri , Kim Youngchun , Jo Jaeseong
Published: July 2022

This work investigates the role of South Korean mothers in their children’s academic success. The researchers conducted a qualitative case study on a total of 20 mothers and their children. The results are as follows. First, Korean mothers physically, mentally, and behaviorally build an environment where their children naturally internalize the value of studying. Second, mothers pass down effective studying methods to their children. Korean mothers help their children improve grades and understand study materials based on the mothers’ past learning experience. Third, they invest heavily in shadow education. To provide timely shadow education meeting the needs of their children, mothers financially sacrifice themselves regardless of their income. Lastly, mothers gather and sort out information about admission, schools, and shadow education. They collect useful information from parents’ groups, school teachers, private tutors, and online communities, and curate it for their children. This work sheds light on the systematic educational strategies of Korean mothers from a novel perspective. The researchers call them “bear mothers” based on their wisdom and sacrifice. The researchers hope that this study helps scholars conceptualize the importance of educational involvement and that it encourages future studies to discover the factors behind Korean students’ academic success.
An Itinerant Teacher’s Experience in Adapting at Facilities for Students with Disabilities
Authors:   Korean Association for Qualitative Inquiry, Lee Jeongmi , Lim Kyoungwon
Published: July 2022

This study was aimed to reflect on myself and to find socio-cultural meaning by sharing my experiences as an itinerant teacher and my interactions with the surrounding culture, using self-cultural descriptive papers, and to give implications for special education. In order to achieve the purpose of this study, the researcher collected memory data, self-reflection data, cultural artifacts, self-observation data, call records, and transcripts of various conferences related to itinerant education for 4 years and 3 months. The collected data were analyzed by applying a comprehensive analysis procedure based on pragmatic eclecticism. The result of the study showed, first, it was not only an individual ability problem that caused itinerant teachers to have difficult in class. Second, the answer to the frustration and confusion caused by the students was eventually found in the students. Third, the most important thing in relation to facilities was how to build a rapport. Fourth, it was the receptive atmosphere and interest in the school that help itinerant teachers feel positive about teacher efficacy. Fifth, all the difficulties and confusion that itinerant teachers may have in the field of itinerant education could be overcome through cooperative relationships with higher-level institutions including the learning community of itinerant teachers, not through individual efforts of the itinerant teachers. The results of this study will be the basis to better understand the itinerant education, which has not been getting much attention in the past. In addition, it will be of comfort to itinerant teachers who, including myself, are struggling with itinerant education.
A Qualitative Study on Counseling and Psychotherapy Experiences of Female College Students
Authors:   Korean Association for Qualitative Inquiry, You Eunhae , Han Kyeonga , Park Sojung , Lee Jihyun
Published: July 2022

The purpose of this study is to explore and understand various meanings of female college students’ counseling and psychotherapy experiences. In-depth interviews were conducted with 7 female college students aged 20-24 at A University in Seoul, and as a result of data analysis, a total of 5 themes and 14 sub-themes were derived. The conclusions based on the research results are as follows. First, participants felt burdened and dissatisfied in the early stages of counseling and psychotherapy, but as they began to understand the counseling and psychotherapy process and counselors, they experienced changes, accepting their inner self. Second, participants expanded perception and gained confidence in themselves in the course of counseling and psychotherapy, and mentioned that various media and counselors were significant factors to promote change. Third, the participants showed a desire for counseling and psychotherapy to build solidarity and feel empathy with the unique experience they had as female college students. Fourth, participants were actively using counseling and psychotherapy services offered at student counseling centers in the university, but said there was room for improvement for the counseling structure, showing the need of continuous counseling services. This study is meaningful in that it explored the experience of female college students in counseling and psychotherapy and discussed ways to address practical needs.
PERLINDUNGAN HUKUM KORBAN INVESTASI BINARY OPTIOM BERKEDOK TRADING
Authors: H Ferrario M
Published: July 2022

Pandemi COVID-19 telah menghancurkan roda perekonomiam, berbagai lapisan masyarakat terkena dampak  dari pandemic ini, akibat dari pandemic ini roda perekonomian masyarakat menjadi tidak stabil. Masyarakat Indonesia mulai mencari cara dalam mengelola keuangan dengan lebih baik agar dapat bertahan dalam situasi pandemi ini, salah satu caranya dengan berinvestasi. Binary Option Trading menjadi hal yang cukup banyak dibicarakan publik belakangan ini, dikarenakan banyak influencer dan iklan-iklan bertebaran mengenai keuntungan besar yang bisa didapatkan melalui Binary Option Trading. dalam Peraturan Bappebti No. 3 Tahun 2019 tentang Komoditi, Binary option tidak termasuk dalam subjek yang tertulis di Pasal 1. Hal ini secara tidak langsung dapat diartikan bahwa Binary Option ilegal.
KEABSAHAN PERJANJIAN PINJAM NAMA (NOMINEE) DALAM PERJANJIAN PINJAMAN UANG DI INDONESIA
Authors: Wardhana Tri Aji Nur Dewa Kusuma
Published: July 2022

Perjanjian pinjam nama (nominee) adalah perjanjian yang belum ada pengaturannya secara khusus dalam Kitab Undang-Undang Hukum Perdata (KUHPerdata), tetapi tumbuh dan berkembang dimasyarakat. Perjanjian pinjam nama ini masuk ke dalam perjanjian khusus atau sering disebut perjanjian inominaat. Penelitian ini dilatarbelakangi dan dilakukan dengan tujuan mendeskripsikan pengaturan perjanjian pinjam nama(nominee) sebagai bentuk perjanjian dalam pinjaman uang yang telah berkembang dan dilakukan masyarakat saat ini. Metode penelitian menggunakan penelitian hukum normatif. Berdasarkan temuan penelitian diketahui bahwa tidak tersedianya aturan secara khusus untuk  perjanjian pinjam nama yang diatur dalam undang-undang (KUHPerdata). Selama para pihak bisa menjalankan perjanjian dengan baik sesuai ketentuan Undang-Undang tentang sahnya perjanjian dan mengenai perjanjian pinjaman yang sudah diatur di dalam KUHPerdata, perjanjian tersebut bisa dikatakan sah di mata hukum jika telah sesuai dengan syarat perjanjian dalam KUHPerdata
ANALISIS PUTUSAN MK NO.91/PUU-XVIII/2020 TERHADAP PERPRES NO.113 TAHUN 2021 TENTANG STRUKTUR DAN PENYELENGGARAAN BANK TANAH
Authors: Windyantoro Widy Angga , Simangunsong Frans
Published: July 2022

Adanya UU Cipta Kerja yang baru tidak serta merta membuat produk hukum yang baik dan dapat diterima oleh masyarakat merupakan mutlak adanya harus berlaku di dalam sistem perundang undangan di Indonesia. Adanya UU Cipta Kerja tentang pengadaan bank tanah sebagaimana dimaksud apabila dilihat di dalam putusan MK NO.91/PUU-XVIII/2020 memiliki banyak konsekuensi hukum diantaranya bank tanah merupakan salah satu kebijakan strategis dimana kebijakan strategis dan berdampak luas itu harus ditangguhkan. Metode penelitian yang digunakan dalam penelitian ini adalah penelitian hukum normatif. Dalam penelitian ini digunakan beberapa pendekatan, yaitu pendekatan perundang-undangan, pendekatan konseptual dan pendekatan kasus. Adapun hasil dari penelitian diketahui bahwa mendorong adanya perubahan yang mendasar dan segera terhadap UU Cipta Kerja. Hal tersebut, secara praktis, agar tujuan-tujuan idealis yang ingin dicapai dari hadirnya UU Cipta Kerja dapat tetap terlaksana sekaligus meminimalisasi konsekuensi negatif yang ditimbulkan dengan menghindari ‘sanksi’ dari MK berupa putusan inkonstitusional terhadap UU Cipta Kerja Perbaikan-perbaikan yang diperlukan.
PERLINDUNGAN HUKUM TERHADAP PHK IPEKERJA SEPIHAK AKIBAT GUGATAN INDUSTRIAL YANG MASIH DALAM PROSES
Authors: Zein Mochamad Adam Fahreza
Published: July 2022

Perlindungan dan jaminan kepastian hukum Ketenagakerjaan mulai mendapatkan tempat setelah keluarnya Undang-undang No 13 Tahun 2003 tentang Ketenagakerjaan dimana posisi Pekerja/buruh dan Pengusaha/Perusahaan mendapatkan posisi yang seimbang, Mekanisme penyelesaian perselisihan hubungan industrial yang diatur Undang-Undang Nomor 2 Tahun 2004 seakan menjadi kontradiktif ketika putusan batal demi hukum dengan kewajiban pengusaha untuk mempekerjakan kembali pekerja yang telah dilakukan PHK sepihak banyak tidak dilaksanakan pengusaha termasuk putusan yang  dikeluarkan oleh pengadilan sekalipun. Pemutusan Hubungan Kerja (PHK) dapat dilakukan jika dilakukan tidak dengan cara sepihak dan merugikan para pekerja/buruh. Perlindungan hukum mengenai Pemutusan Hubungan Kerja (PHK) secara sepihak telah diatur dalam Pasal 153 Undang-Undang Cipta Kerja,yang dimana dalam pemutusan hubungan kerja pengusaha memiliki larangan untuk melakukan pemutusan hubungan kerja (PHK). Pemutusan Hubungan Kerja (PHK) secara sepihak sangat tidak diperbolehkan
KEWENANGAN PEMERINTAH DAERAH DALAM PENGAWASAN PERTAMBANGAN MINYAK
Authors: Pratiwi Diah Ayu , Suhartono Slamet
Published: July 2022

Penelitian ini bertujuan untuk mengetahui dan memahami dimana letak kewenangan pemerintah daerah dalam pengawasan tambang minyak. Bentuk penelitian ini menggunakan penelitian hukum normatif dengan menggunakan spesifikasi penelitian menjadi penelitian eksploratif dimana penelitian ini bertujuan untuk memperdalam asas dan asas pengaturan yang terkait dengan aspek pengaturan kewenangan pemerintah pusat dan daerah untuk pengawasan penyidikan dan penyidikan industri perminyakan. . Kewenangan izin pertambangan mineral dan batubara ada di pemerintah pusat dan provinsi. Pemerintah kabupaten/kota tidak berwenang menentukan diberikan atau tidaknya izin pertambangan. Pada prinsipnya, kewenangan penerbitan izin pertambangan ada pada Kementerian ESDM. Pasal 11 (1) Undang-Undang Pemerintah Daerah Nomor 23 Tahun 2014 menyebutkan: Urusan Pemerintahan Serentak Dalam pengertian Pasal 9 (3) yang menjadi kewenangan daerah meliputi urusan pemerintahan wajib dan pemerintahan preferensial. UU Pertambangan dan Pertambangan No. 4 Tahun 2009 tidak hanya memberikan kewenangan kepada pemerintah provinsi tetapi juga pemerintah kabupaten/kota. Pasal 8(1) Undang-Undang Pertambangan Mineral dan Batubara Nomor 4 Tahun 2009 menyebutkan bahwa kewenangan pemerintah kabupaten/kota dalam pengelolaan pertambangan mineral dan batubara berbeda dengan Undang-Undang Nomor 23 Tahun 2014 tentang pemerintahan daerah. Undang-undang ini tidak mengatur kewenangan pemerintah kabupaten/kota untuk menerbitkan Izin Usaha Pertambangan (IUP) dan Izin Usaha Pertambangan Rakyat (IPR).
ATENDIMETOS POR COVID-19 REALIZADOS PELO SERVIÇO MÓVEL DE URGÊNCIA AVANÇADO NA REGIÃO DE TAQUARA/RS.
Authors: QUADROS ALEXANDER DE , Ficanha Dalvan , Carollo Fernandes Morgana Thaís
Published: July 2022

Objetivo: caracterizar o perfil dos pacientes com a COVID-19, atendidos pelo Serviço Móvel de Urgência (SAMU) no município de Taquara, Rio Grande do Sul. Métodos: estudo descritivo e exploratório, retrospectivo com abordagem quantitativa, realizado a partir de dados obtidos nos boletins de atendimento do SAMU de Taquara/RS, no período de março de 2020 a março de 2021. Amostra composta por 66 pacientes. Resultados: Foi observada a predominância do sexo masculino, 69,7 % (n=46), com média de idade de 59,7 (dp=14,8) anos. Quanto ao destino, prevaleceu o setor de UTI, 53,0 % (n=35). Obteve-se associação estatisticamente significativa quanto ao tipo de atendimento realizado ao paciente (p=0,023), onde o sexo feminino associou-se ao atendimento, 65,0% (n=13). Associou-se estatisticamente também os pacientes com a COVID-19 confirmada ao turno das 12:00 às 17:59 min, 50,0 % (n=16) (p=0,039). Foi possível inferir que é relevante a caracterização destes atendimentos para subsidiar a consolidação de políticas públicas e ações em saúde.
Innovation Behavior of Small and Medium Enterprises in the Philippines
Authors:   De La Salle University, Philippines, Lim Cristina Teresa N.
Published: July 2022

Due to the emergence of technology, there has been a rapid transformation of the way things are done as a result of digitalization innovation for small and medium enterprises (SMEs) in the Philippines to remain competitive. The purpose of this study is to present an overview of innovative behavior and perception among SMEs surveyed from the 2015 World Bank Enterprise Survey and from the 2015 Survey of Innovation and Activities of Establishments for the Philippines. Analysis of the innovation components such as product innovation, process innovation, and mapping of the main innovative activities was examined. The results showed that SMEs spend less on formal research and development and have less purchase or license of any patented or non-patented inventions. Moreover, SMEs provide less formal training to any of its employees specifically for the development and/or introduction of new or significantly improved product services and processes. Innovation showed a negative covariance which means that innovation and R&D expenditures tend to move in inverse directions. This situation should allow the government to come up with national policy interventions that support and encourage innovation especially for the SMEs.
The Popularity of Milk Tea Amidst Covid-19 Pandemic: Perspectives of Selected Entrepreneurs in Minglanilla, Cebu Philippines
Authors:   University of San Carlos (Philippines), St. Cecilia's College Cebu Inc. (Philippines), University of the Visayas (Philippines), Bastasa Kriszia Dimpsy S. , Maravilla Vicente S. Jr , Espellita Simplicio R. Jr , Calzada Ritchell Dela , Alqueza Jessalyn M.
Published: July 2022

Milk tea became so popular that numerous entrepreneurs tried to venture into this business. The Philippines is dubbed the second-most populous country in Southeast Asia regarding bubble tea users. Though the Philippines was dubbed as such, it was not until late 2019 that Pearl Milk Tea exploded its popularity in the country. It paved the way for the tea-enthusiast to venture into the business by experimenting with various creamers, flavors, and sweeteners. In Minglanilla, Cebu, Philippines, there is also a growing Milk tea shop on every corner of the street; however, before the boom reached a year, a pandemic halted every operation on every establishment. Through a phenomenological approach, the researchers of this study interviewed the owners and management of milk tea businesses in this new level of difficulty. The study's significant findings merged the theme scope, including Covid-19 Business Impact, Digital Marketing, Adapt Delivery Services, Safety and Security Protocols, and Menu Engineering. Furthermore, findings suggest that Covid-19 negatively impacted business establishments. Nevertheless, the management and entrepreneurs still push through and invest more in their business, with a clear perspective of success and execute modern alternatives that keep the business operating.
VISÃO DOS PROFISSIONAIS DA ATENÇÃO BÁSICA DE SAÚDE SOBRE A EDUCAÇÃO POPULAR EM SAÚDE DO HOMEM
Authors: BARBOSA ANICETO GYNA KARINE
Published: July 2022

A saúde é um direito de todos e um dever do Estado no Brasil, onde dentre os sistemas de saúde nacional encontra-se os serviços de Atenção Básica de Saúde representada atualmente, principalmente pelas Estratégias de Saúde da Família que dentre suas atribuições está a saúde do homem e a realização de educação em saúde. Desta maneira, esta pesquisa tem por objetivo verificar a visão dos profissionais da atenção básica de saúde de Passira – PE acerca da educação popular em saúde do homem. Foi atribuído como percurso metodológico, uma pesquisa descritiva opinativa de abordagem qualiquantitativa realizada com profissionais de saúde atuantes nas Estratégias de Saúde da Família de Passira – PE, na qual a coleta de dados ocorreu por instrumento indexado em plataforma online sendo distribuído por meio de mídias digitais. Quanto a análise de dados ocorreu por dois meios, estatística descritiva e análise de conteúdo. No que se refere aos principais resultados, identificou-se na visão dos participantes um bom nível de conhecimento acerca da saúde dos homens, seus principais aspectos e da educação em saúde. Verificou-se também que a educação em saúde é uma pratica corriqueira executada pelos profissionais participantes inclusive com a população masculina. Todavia foi visto que mesmo a educação em saúde considerada majoritariamente como provocadora de efeitos benéficos positivos para os homens, existem desafios na inserção deste público nos processos educativos. Sendo assim, concluiu-se que os achados desta pesquisa conseguiram cumprir os objetivos propostos.
O DESAFIO DO USO DAS TECNOLOGIAS NA FORMAÇÃO DOS PROFESSORES DA ZONA RURAL DO MUNICÍPIO DO CAREIRO CASTANHO
Authors: LIRA DE PAULA IZAQUE
Published: July 2022

Esta dissertação realiza uma análise acerca da dos desafios do uso da tecnologia no processo de formação do professor. A sociedade contemporânea vem passando por processos de constantes mudanças, sobretudo com destaque para o uso das tecnologias informação e comunicação e também as digitais, nas mais variadas áreas da sociedade e no desenvolvimento das atividades humanas, inclusive na área educacional. Parte-se da premissa que, a educação é um instrumento de transformação social, que acompanha as mudanças ocorridas na esfera global, implicando numa concepção nova das ações e estrutura da instituição educacional, influenciando os programas que promovem os processos de formação inicial e continuada dos professores. O objetivo geral desta pesquisa consiste em: Analisar os desafios promovidos pelo uso da tecnologia no processo de formação de professores da zona rural do município do careiro castanho. Os Objetivos específicos definidos por esta pesquisa são: Apresentar os principais aspectos da formação de professores diante da legislação brasileira; Compreender a Política de Educação destinada a formação inicial e continuada de professores; Refletir acerca dos desafios contemporâneos pelo uso das tecnologias no contexto da formação de professores. Diante dos objetivos traçados, optou-se pela metodologia de pesquisa bibliográfica refletindo acerca da problemática que apreende a formação do professor e o uso das tecnologias, desta forma, a pesquisa, inicialmente realizou um mapeamento bibliográfico, onde foi possível selecionar livros, artigos, teses, revistas eletrônicas e legislação na área presente temática, o que forneceu subsídios teóricos para a elaboração dessa tese. Através desta pesquisa, observou que, as transformações contemporâneas vêm ocorrendo em vários campos da sociedade promovidos pelas tecnologias que exigem novas posturas em relação à incorporação desses recursos tecnológicos à prática educativa. Por fim, através desta pesquisa, foi possível verificar que as tecnologias da informação e comunicação e as digitais oferecem muitos subsídios para a vida cotidiana, sendo que a área educacional ao acompanhar os avanços propiciados por essas tecnologias vem fazendo uso das mesmas nos processos de formação de professores.
Implementation of the system for maintenance management of road structures at the Nikola Tesla Airport in Belgrade
Authors: Nešković Nemanja , Kovačević Goran , Vajdić Nevena
Published: July 2022

At the Nikola Tesla Airport in Belgrade, the need for the introduction of the Airport Pavement Management System (APMS) has been recognized for a long time, which would improve the existing procedures and enable the most optimal use of funds intended for maintenance. In 2019, testing and configuration of such a system began. The paper presents the characteristics of the system itself and the challenges that arose during implementation.
Degradation of chlothianidin from Dantutso 50WG in electrochemical process: Kinetics and role of reactive species
Authors: Nguyen Tien Hoang
Published: July 2022

The kinetic degradation of clothianidin (CLO) (in Dantuso 50 WG) during electrochemical oxidation (EO) process using sulfate- and chloride-supporting electrolytes was comprehensively investigated. The degradation of CLO was not due to direct electron oxidation, but was mainly due to •OH and other radicals generated from supporting electrolytes. The degradation of CLO was significantly inhibited when increasing the concentration of nitrobenzene (NB), methanol (MeOH) and benzoic acid (BA). The second-order rate constant of •OH toward CLO was determined to be 3.23×109 M-1 s-1 using competition kinetics method. When SO42- and Cl- were used as supporting electrolytes, the degradation of CLO by •OH was the same with kCLO = 0.0084 min-1. Meanwhile, the higher removal of CLO in SO42--supporting electrolyte was due to the contribution of (SO4•-/S2O82-) more than that of (Cl•/HClO/ClO-).
The prediction of pKa values for phenolic compounds by the DFT theory
Authors: Nguyen Nguyen Thi My, Nguyen Van Din, Mai Van Bay
Published: July 2022

The acid dissociation constant is an important parameter that affects the physicochemical properties of molecules in solution. A set of 20 phenolic compounds were used to establish a model to predict  values of phenolic compounds. Calculations in aqueous medium were performed with a polarizable continuum solvent model (PCM) and three hybrid DFT functionals (B3LYP, PBE0, ωB97XD and M062X) with the basis set 6-311++G(d,p). The directly calculated value of  gives less accurate results with an average absolute error (MAE) of 1.74  units when using the ωB97XD functional and phenol as reference compound. In the case of using statistical correction, the accuracy of  is greatly improved. In the case of using statistical correction, the accuracy of  is greatly improved with the lowest MAE value of 0.14  units (M062X; ). The calculated results of  in this study have the same accuracy as the experimental measurements.The acid dissociation constant is an important parameter that affects the physicochemical properties of molecules in solution. A set of 20 phenolic compounds were used to establish a model to predict  values of phenolic compounds. Calculations in aqueous medium were performed with a polarizable continuum solvent model (PCM) and three hybrid DFT functionals (B3LYP, PBE0, ωB97XD and M062X) with the basis set 6-311++G(d,p). The directly calculated value of  gives less accurate results with an average absolute error (MAE) of 1.74  units when using the ωB97XD functional and phenol as reference compound. In the case of using statistical correction, the accuracy of  is greatly improved. In the case of using statistical correction, the accuracy of  is greatly improved with the lowest MAE value of 0.14  units (M062X; ). The calculated results of  in this study have the same accuracy as the experimental measurements.
Cash flows – investment sensitivity under financial constraints: The case of Vietnam
Authors: Thai Thai Thi Hong An, Ha Le Hong Ngoc
Published: July 2022

This paper focuses on examining the relation between cash flow and investment within different corporate financial status in the context of Vietnamese market. Using a sample of non-financial quoted firms over the 13-year period from 2005 to 2017; We document a strong positive correlation between corporate investments and cash flows. Importantly, our results indicate that firms suffering lower level of financial constraints appear to experience stronger investment to cash flow sensitivity and vice versa. This finding provides new evidence to re-examine the existing controversy on the use of investment & cash flow co-movement as a measurement of corporate financing constraints.