bluuebunny/crossref_metadata_2025 huggingface dataset:
Plasma proteomic profiles of healthy and mastitic cows – host responses to bovine mastitis
Authors: Niu L.L. , Wei C.H. , Du L.X.
Published: January 2019

Abstract. Mastitis is the most common disease in dairy cows and has resulted in a tremendous economic loss in dairy industry. In the present study, differentially expressed proteins (DEP) were identified among healthy, moderate and severe mastitic cows by proteomic profiling. The health status of cows was closely determined by the somatic cell count (SCC). Differentially expressed proteins were resolved using the two-dimensional gel electrophoresis (2-DE) with the pH 4–7 non-linear DryStrips. Subsequently, 8 protein spots, which altered more than 3-fold, were isolated and identified with the matrix-assisted laser desorption/ionisation-time of flight mass spectrometry (MALDI TOF/TOF MS). The identified spots were split into four proteins: α-2-HS-glycoprotein, serum albumin, transthyretin (TTR) and haptoglobin, respectively. Compared with the healthy cows, the expression of haptoglobin was up-regulated in mastitic cows, and the others were down-regulated. Moreover, the proteomic data were consistent with the results of Western blot. All of the identified DEPs were acute phase proteins, which acted together and represented the consequence of serial cascades after mastitic infection. More importantly, the α-2-HS-glycoprotein was novel identified corresponding to the bovine mastitis in Chinese Holstein dairy cows. Taken together, our results indicate that the host responses may play an important role in the pathogenesis of mastitis and provide the potential diagnostic indicator of the underlying mastitis in dairy cows.
A modified Mitscherlich model and its degradation kinetics equations
Authors: Uckardes F.
Published: January 2019

Abstract. The aim of this study was to show how to adapt and convert the Mitscherlich model to animal nutrition studies in a theoretical way. The new form of the model was obtained by applying a mathematical conversion step by step to use the Mitscherlich model in an in vitro gas production or in in situ nylon bag studies which have an important role in animal nutrition. The parameter which is not included in new model but important for digestion was gained for the model. Moreover, it was shown how to obtain important digestion equations by using the new form of Mitscherlich model. Also the equation formulas were obtained for both with and without lag-phase. Consequently, it was shown how to convert a model, which is previously not used in terms of animal nutrition, into a different purposive form and how to obtain the new equations from this form step by step in a theoretical way. Besides, the new form of Mitscherlich model, which is an alternative to other models, will importantly contribute to the literature by obtaining some important equations not found in many of the other models.
Effect of time, amount and frequency of feeding on total egg production, fertility and hatchability in broiler breeders
Authors: Soltanmoradi M. G. , Seidavi A. , Dadashbeiki M. , Delgado F. , Gamboa S.
Published: January 2019

Abstract. The effects of timing, the amount and the frequencies of feeding on the performance of broiler breeders (Ross 308) at the age of 31–38 weeks were studied. The broiler breeders were randomly assigned to each of 15 treatments (T). These included day feedings, in which birds were fed once at 4.00 (T1 = control), twice (T2 to T7), thrice a day (T8 to T13) and four (T14 and T15) times per day. The daily feed allotment was divided into different ratios with different time schedules. The nutritional composition of all experimental groups was similar. Eggs were collected at 8.00, 10.00, 14.00 and 16.00. The results obtained showed that feeding schedule resulted in significant differences (P < 0.05) in egg production (% hen), as well as in fertility and hatchability. Results obtained in our study suggest that allocation of restricted feed two times a day, in a 75 : 25 ratio (4.00 and 12.00) improved egg production, fertility and hatchability.
AVALIAÇÃO DOS SERVIÇOS EM BIBLIOTECA UNIVERSITÁRIA: O CASO DA BIBLIOTECA SETORIAL PROF. CANDIDO ATHAYDE DA UFPI
Authors: Silva Hernandes Andrade , Leite Francisca das Chagas Dias
Published: January 2019

A avaliação é um instrumento indispensável ao planejamento e gestão das bibliotecas universitárias. Neste caso, estas unidades de informação têm a necessidade de acompanhar a evolução das informações e tecnologias, por isso o desempenho eficaz de seus produtos e serviços são fundamentais no processo de transferência e democratização do conhecimento. O objetivo do presente trabalho foi realizar um diagnóstico da Biblioteca Setorial Prof. Cândido Athayde da UFPI - Campus Parnaíba, bem como avaliar o atendimento, acervo e qualidade dos serviços/produtos prestados aos seus consulentes. Metodologicamente a pesquisa ostenta-se em um estudo de caso. Dessa forma refere-se a uma pesquisa de natureza quantitativa e qualitativa com caráter exploratório descritivo. Constatamos, a partir do estudo, que alguns indicadores revelaram desempenho insatisfatório tais como equipamentos de informática, sala de leitura, silêncio, levantamento bibliográfico e orientação à normalização para trabalhos científicos. Esses resultados embasam a necessidade da implementação de ações que visem à melhoria desses serviços, a fim de nortear o planejamento bibliotecário.
SERVIÇO DE INFORMAÇÃO AO CIDADÃO DO MINISTÉRIO DA PREVIDÊNCIA SOCIAL: instrumento de democratização da Informação
Authors: Barros Dirlene Santos , Sousa Renato Tarciso Barbosa de
Published: January 2019

Análise da eficácia do Serviço de Informação ao Cidadão (SIC) do Ministério da Previdência Social (MPS). Trata-se de uma pesquisa bibliográfica e documental de abordagem qualitativa com aplicação de entrevista semiestruturada a Gestora da Assessoria de Gestão Estratégica e Inovação Institucional (AGEIN). Verificou que o SIC proporciona um movimento diferenciado não só no provimento do acesso à informação, mas também, em conduzir o MPS a pensar sobre a sua cultura organizacional, sendo preciso intensificar a divulgação do SIC físico à população. Conclui que o SIC do MPS pelas abordagens desdobradas, de uma forma geral, atua de forma eficaz no provimento das informações ao cidadão.
EL MANEJO DE LA CONFIDENCIALIDAD EN EL TRATAMIENTO DE LA INFORMACIÓN
Authors: Luna Gonzalez Mary Eugenia , Luna Gonzalez Mary Eugenia
Published: January 2019

Uma análise da ética do profissional de informação, especificamente em relação a alegada ética estabelece os limites entre o que é confidencial e que não; com base nos artigos do código de ética da Associação de bibliotecários e Archivologos da Venezuela, que se relacionam com o acesso à informação.
O PENSAMENTO FUNCIONALISTA NA ARQUIVOLOGIA, NA BIBLIOTECONOMIA E NA MUSEOLOGIA
Authors: Araújo Carlos Alberto Ávila
Published: January 2019

Arquivologia, Biblioteconomia e Museologia se constituíram, como disciplinas científicas, no final do século XIX, a partir da consolidação de um modelo que valorizava os acervos custodiados nas instituições arquivo, biblioteca e museu, bem como os princípios de tratamento técnico destes acervos. Foi com a presença de um pensamento funcionalista que as três áreas ampliaram seu escopo de estudos e problematizações. Nesta ampliação, também se fizeram sentir condições propícias para um maior diálogo e fortalecimento mútuo entre as três áreas.
Capa e páginas iniciais
Authors: Pretto Nelson De Luca
Published: January 2019

Capa e páginas iniciais
RELENDO LÊNIN: UM BALANÇO DO DEBATE CONTEMPORÂNEO SOBRE O IMPERIALISMO
Authors: Pansardi Marcos Vinícius
Published: January 2019

Este texto aborda o surgimento do conceito fecundo de imperialismo, na segunda década do século XX, a desconfiança em seu uso que se instala na década de 1970, seu retorno na década de 1990 e início do século XXI, apropriado por visões reformistas e conciliatórias. Todavia, no seio do contexto atual, retoma-se Lênin e Gramcsi, instala-se na esquerda o debate cuja finalidade não é outra que entender e explicar o mundo, recorrendo a releituras dos clássicos e sua atualização.
PERSPECTIVAS DE ESTUDOS SOBRE A FORMAÇÃO DO SEM-TERRA: O USO DAS CATEGORIAS DO UNIVERSAL, PARTICULAR E SINGULAR
Authors: Garcia Fátima Moraes
Published: January 2019

RESUMO:

Esta produção científica trata de subsídios teóricos com base no materialismo histórico dialético, associado de forma objetiva à relevância de aprofundar a compreensão e apreensão dos engendramentos existentes entre o universal, o particular e o singular na e sobre a formação humana do sem-terra. A necessidade de debater e aprofundar este tema decorre da emergência teórica e metodológica que entendemos estar posta pelos estudos vinculados aos movimentos sociais e seus processos educativos no campo do marxismo.

 

 
Expediente
Authors: Peixoto Elza Margarida de Mendonça
Published: January 2019

Dados Técnicos referentes aos sistema de edição do periódico.
Editorial
Authors: Orso Paulino José
Published: January 2019

Apresentação da temática e do material disseminado número.
DESAFIOS DA HISTÓRIA DA EDUCAÇÃO NA PERSPECTIVA MARXISTA
Authors: Pereira Maria de Fátima Rodrigues
Published: January 2019

O texto desvela os desafios que a teoria marxista e sua concepção de história, em interlocução com a primeira geração da Escola Des Annales, coloca à História da Educação. Este estudo ainda ressalta o caráter ético- político da concepção de história marxista, no debate com setores pós-modernos. Também, apresenta o compromisso revolucionário e emancipatório dessa perspectiva para a pesquisa e o ensino da História da Educação
CONTRIBUIÇÕES DOS POSTULADOS MARXISTAS PARA ENTENDER A HISTORIA DA EDUCAÇÃO
Authors: Carlos da Silva João , Vitorino da Silva Mara Cristine
Published: January 2019

Este artigo discute alguns postulados marxistas, no contexto do debate historiográfico atual. Longe de ser uma ciência neutra, a historia da educação sempre esteve a serviço de determinados objetivos políticos. Buscamos uma visão panorâmica do processo de construção da concepção materialista-dialética da histórica. Pretendemos pontuar algumas questões teórico-metodológicas partindo dos seguintes questionamentos: Os postulados marxistas têm algo a contribuir para entender a história da educação? classe social é uma categoria superada para estudar história da educação? Nossa análise está calcada na leitura de algumas obras de Marx, observando nelas elementos que ajudam nesta compreensão.
EDUCAÇÃO, HISTÓRIA, POSSIBILIDADES E OS LIMITES
Authors: Orso Paulino José
Published: January 2019

Tomando como referência a história e educação, Paulino José Orso, seu artigo denominado “Educação, história, possibilidades e limites”, analisa as possibilidades e os limites da educação. Para isso, por um lado, percorre a educação ao longo da história e verifica as mudanças pelas quais foi ela passando ao longo dos diversos períodos históricos, em função das transformações ocorridas nas forças produtivas materiais da sociedade. Por outro, a partir do significado da Comuma de Paris de 1871, procura extrair as lições para pensar a educação. Com base nisso, tendo presente a sociedade concreta, permeada por antagonismos e contradições, marcada pelas classes sociais, procura depreender as possibilidades e os limites da educação na atualidade.
REFLEXÕES SOBRE A PARTICIPAÇÃO POLÍTICA DO MOVIMENTO DOS EDUCADORES NA SOCIEDADE DE CLASSES
Authors: Santos Slvia Alves dos
Published: January 2019

Este artigo trata de uma reflexão sobre a participação política do movimento dos educadores no Brasil a partir das mobilizações pela redemocratização do país. Inicia fazendo uma breve discussão sobre as relações entre Estado e sociedade e a importância da participação política dos sujeitos na construção de outra sociedade mais justa e igualitária. Essa luta sempre esteve balizada pelos interesses antagônicos das classes em disputas por projetos políticos no país. Tais conflitos, acirrados pelas crises cíclicas do capital que se reestrutura de tempos em tempos, mostram-nos o desafio em construir mecanismos de contra-hegemonia que possam consolidar-se em ações de enfrentamentos às injustiças sociais que assolam os direitos da classe trabalhadora.
PRODUÇÃO DE CONHECIMENTOS E DEPENDÊNCIA ACADÊMICA: QUAL O NOSSO PROJETO SOCIETÁRIO?
Authors: Gama Zacarias
Published: January 2019

Este texto discute a posição do Brasil e sua possível dependência acadêmica aos países da União Europeia que estão a se organizar no que tem sido chamado de Sociedade e Economia do Conhecimento desde a assinatura do Tratado de Bolonha. A concretizar esta relação, a hipótese é de que a produção de conhecimentos em nosso país e em nossas universidades e centros de pesquisa se restrinjam a conhecimentos básicos, comoditizados, para que os países mais desenvolvidos lhes agreguem valor e intensifiquem os seus processos de acumulação de capital através da venda e cobrança de royalties. Esta dependência acadêmica tende, então, a repetir padrões típicos da exploração colonial: produção de mais-valia absoluta em nossas universidades e centros de pesquisa, e produção de mais-valia relativa fora das nossas fronteiras.
PÓS-GRADUAÇÃO EM TEMPOS DE PRECARIZAÇÃO DO TRABALHO: ALONGAMENTO DA ESCOLARIDADE E ALTERNATIVA AO DESEMPREGO. QUANDO MAIS É MENOS
Authors: Brunetta Antonio Alberto
Published: January 2019

RESENHA
EDUCAÇÃO E ENSINO NA OBRA DE MARX E ENGELS
Authors: Molina Rodrigo Sarruge
Published: January 2019

Após anos de intensas pesquisas José Claudinei Lombardi publicou no ano de 2011 a obra Educação e ensino na obra de Marx e Engels. Texto derivado de sua livre docência pela Faculdade de Educação da Universidade Estadual de Campinas (FE-UNICAMP), o livro está editado pela Alínea, na cidade de Campinas-SP. No geral, o trabalho pretende colaborar com a crítica das atuais transformações político-ideológicas que vêm ocorrendo nas universidades “públicas” do Estado de São Paulo, notadamente neoliberais (elitistas, privatizantes e antimarxistas). Para além das críticas ao atual sistema, o livro também objetiva auxiliar os educadores no empreendimento de uma ruptura com a educação burguesa, vislumbrando a possibilidade de o proletariado conduzir, no futuro, sua educação de forma autônoma e liberta.
LENDO "O CAPITAL"COM DAVID HARVEY
Authors: Rossi Rafael
Published: January 2019

O livro: “A Companion to Marx’s Capital” é de autoria de David Harvey, professor da City University of New York, pesquisador que se tem dedicado há vários anos ao estudo da Geografia Urbana. A perspectiva materialista-dialética do autor se utiliza do paradigma marxista para o enfrentamento da compreensão neoliberal das questões que estruturam o atual processo de produção do espaço urbano, inserido no modo de produção capitalista.
EMANCIPAÇÃO HUMANA (EDITORIAL)
Authors: Rodrigues Pereira Maria de Fátima
Published: January 2019

APRESENTAÇÃO DO N. 5, VOLUME 1 DE GERMINAL: MARXISMO E EDUCAÇÃO EM DEBATE.
EMANCIPAÇÃO X EMANCIPAÇÃO: UMA ANÁLISE A PARTIR DAS ABORDAGENS TEÓRICAS DA EDUCAÇÃO FÍSICA ESCOLAR
Authors: Duarte Zuleyka Da Silva
Published: January 2019

O presente trabalho buscou conhecer o significado do conceito emancipação nas propostas pedagógicas crítico superadora e crítico emancipatória. Como percurso metodológico, optamos por pesquisa bibliográfica com enfoque dialético. Concluímos que a abordagem teórica Crítico Superadora, a partir da Pedagogia Crítico Social dos Conteúdos, concebe emancipação, como parte do conceito emancipação humana de Marx. Já a abordagem Crítico Emancipatória, fundamenta sua análise na concepção kantiana de esclarecimento e da teoria da ação comunicativa de Habermas, na perspectiva da emancipação da consciência, sem necessariamente buscar a transformação social.
EDUCAÇÃO INTEGRAL, INTERCULTURAL E SISTÊMICA: “A HEGEMONIA ÀS AVESSAS” NO PROGRAMA MAIS EDUCAÇÃO
Authors: Silva Jamerson Almeida , Silva Katharine Ninive Pinto
Published: January 2019

Oartigo analisa o Programa Mais Educação desenvolvido pelos Governos Lula /Dilma, desvelando a concepção de Educação Integral que está assentada numaproposta intersetorial e sistêmica de gestão a partir do PDE. Através deanálise documental, evidenciamos que o programa expressa uma propostapolítico-pedagógica eclética, articulando “Educação Intercultural” e“Neotecnicismo”, teorias aparentemente incongruentes, mas que são dimensões da“hegemonia às avessas”, marca essencial do projeto político-ideológico dosgovernos em foco.
MANIFESTO DO PARTIDO COMUNISTA
Authors: Marx Karl
Published: January 2019

Manifesto que contém o Programa do Partido Comunista para a revolução que propõe a superação do modo capitalista de produção da existência.
EXPEDIENTE
Authors: Peixoto Elza
Published: January 2019

Expediente
ORGANISMOS INTERNACIONAIS NO BRASIL E EM PORTUGAL: UMA (CON)FORMAÇÃO VOLTADA PARA O CAPITAL
Authors: Souza Camila Azevedo
Published: January 2019

Este estudo analisa a atuação dos organismos internacionais no Brasil e em Portugal, tendo em vista as repercussões para as políticas educacionais nessas duas formações sociais concretas. Com base no método do materialismo histórico e, mais especificamente, nas formulações de Antonio Gramsci, busca-se evidenciar as relações de hegemonia que atravessam as diretrizes educacionais desses organismos, identificando em que medida a classe dominante reafirma e consolida a concepção burguesa de mundo em projetos educativos.

Palavras-chave: organismos internacionais; políticas educacionais brasileira e portuguesa; hegemonia
A RELAÇÃO ENTRE A FUNDAMENTAÇÃO DO TRABALHO PEDAGÓGICO DOS PROFESSORES DO CEFD-UFSM E OS PROJETOS PEDAGÓGICOS DE CURSO
Authors: Couto Maíra Lara , Souza Maristela Da Silva
Published: January 2019

Este estudo investigou a relação entre a fundamentação do trabalho pedagógico dos professores do CEFD-UFSM e os Projetos Pedagógicos de Cursos de EF (PPC). Fundamentadas no método do Materialismo Histórico Dialético, foram realizadas entrevistas com professores sobre os PPC dos cursos. Concluímos que os professores do CEFD-UFSM não se baseiam nos PPC para fundamentarem sua prática pedagógica. Isto se torna preocupante já que em breve a Licenciatura Ampliada em EF estará em prática. Apesar disso, entendemos que o novo curso, sendo pauta transitória, na medida em que é expressão de reivindicações da base contribuirá com novos patamares de conhecimento.
 
A POLÍTICA DE EDUCAÇÃO DO CAMPO E A LUTA DE CLASSES NO BRASIL CONTEMPORÂNEO: QUESTÕES PARA ANÁLISE DA CONJUNTURA.
Authors: Santos Cláudio Félix dos , Teixeira David Romão
Published: January 2019

<span style="font-size: 11.0pt; line-height: 115%; font-family: ";Garamond";,";serif";; mso-fareast-font-family: Calibri; mso-bidi-font-family: ";Times New Roman";; mso-ansi-language: PT; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;" lang="PT">O texto<span style="font-size: 11.0pt; line-height: 115%; font-family: ";Garamond";,";serif";; mso-fareast-font-family: Calibri; mso-bidi-font-family: ";Times New Roman";; mso-ansi-language: PT; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;" lang="PT"> tem como objetivo discutir a educação do campo e alguns aspectos da implementação desta política educacional no contexto da crise do capital e listar alguns dos problemas contemporâneos e proposições hegemônicos da Educação em geral e da Educação do campo em especial. No esforço para ter coerência teórica com o materialismo histórico, que além de explicar requer um compromisso de transformar a realidade,  apresentaremos o que consideramos fundamental para a Educação do Campo não se tornar mais uma elaboração da classe trabalhadora subsumida a ordem burguesa.
Excluídos ou sujeitos sociais? A condição de desempregado e a luta coletiva pelo trabalho
Authors: Machado Rita de Cassia Fraga , Leal Giuliana Franco
Published: January 2019

Este artigo é recorte de uma pesquisa de pós-doutorado e de uma pesquisa de mestrado que tiveram como objetivo estudar os sujeitos organizados pelo MTD. Neste sentido, o objetivo é discutir aqui a capacidade de mobilização dos trabalhadores desempregados, trazendo para o debate alguns elementos empíricos: a interpretação que parte deles, organizados num movimento social de luta pelo trabalho, constrói de sua própria condição, bem como seus próprios projetos/propostas políticos de trabalho-renda. Também resgatamos o conceito de trabalho que orienta o fazer político desses sujeitos, organizados em um Movimento Socia, também a partir da pesquisa de cmapo. Argumentamos que os trabalhadores do universo pesquisado não são “excluídos”, mas sim trabalhadores com relações precárias, intermitentes e majoritariamente informais com o mercado de trabalho, fazendo parte, nas posições mais frágeis e marginais, de uma lógica de superexploração e precarização das condições de trabalho presente no capitalismo contemporâneo.
LIBORIO JUSTO: DEL MOVIMIENTO DE NUEVA GENERACIÓN A LA PRIMERA INTERPRETACIÓN TROTSKISTA DE LA REFORMA UNIVERSITARIA (1920-1938)
Authors: Bosch Alessio Constanza Daniela
Published: January 2019

El presente artículo se propone analizar las interpretaciones de Liborio Justo en torno a la Reforma Universitaria en el período 1920-1938, a fines de demostrar cómo sus análisis en relación al proceso evidencian una transformación de su posicionamiento teórico-ideológico. Mientras que sus primeras contribuciones hallan en los postulados americanistas del movimiento “Nueva Generación” la piedra angular del análisis, en 1938 publica la primera interpretación trotskista de la Reforma Universitaria, según la cual, el carácter pequeño-burgués del proceso habría puesto fin a su fase progresiva.

 
A PRECARIZAÇÃO DO TRABALHO E DA EDUCAÇÃO NA CADEIA PRODUTIVA DO SETOR COUREIRO-CALÇADISTA DO VALE DO SINOS (RS)
Authors: Schemes Claudia , Da Silva Cristina Ennes , Kuenzer Acácia Zeneida
Published: January 2019

Este artigo tem como objetivo analisar a articulação entre os processos de precarização do trabalho e da educação na cadeia produtiva do setor coureiro-calçadista do Vale do Sinos, Rio Grande do Sul. Esta investigação se justifica pelo pequeno número de pesquisas que têm sido realizadas na área e, com o intuito de superar estes limites, buscamos integrar diferentes abordagens metodológicas através de procedimentos investigativos interdisciplinares. Para tanto, a pesquisa focalizou a história de empresas que participaram da construção histórica do cluster coureiro-calçadista, uma vez que ela permite apreender, no estudo da história local, as relações entre trabalho, identidade e subjetividade. 
3D Electrophysiological Measurements on Cells Embedded within Fiber‐Reinforced Matrigel
Authors: Schaefer Natascha , Janzen Dieter , Bakirci Ezgi , Hrynevich Andrei , Dalton Paul D. , Villmann Carmen
Published: January 2019

2D electrophysiology is often used to determine the electrical properties of neurons. In the brain however, neurons form extensive 3D networks. Thus, performing electrophysiology in a 3D environment provides a closer situation to the physiological condition and serves as a useful tool for various applications in the field of neuroscience. In this study, 3D electrophysiology is established within a fiber‐reinforced matrix to enable fast readouts from transfected cells, which are often used as model systems for 2D electrophysiology. Using melt electrowriting (MEW) of scaffolds to reinforce Matrigel, 3D electrophysiology is performed on a glycine receptor‐transfected Ltk‐11 mouse fibroblast cell line. The glycine receptor is an inhibitory ion channel associated when mutated with impaired neuromotor behavior. The average thickness of the MEW scaffold is 141.4 ± 5.7 µm, using 9.7 ± 0.2 µm diameter fibers, and square pore spacings of 100, 200, and 400 µm. For the first time, the electrophysiological characterization of glycine receptor‐transfected cells is demonstrated with respect to agonist efficacy and potency in a 3D matrix. With the MEW scaffold reinforcement not interfering with the electrophysiological measurement, this approach can now be further adapted and developed for different kinds of neuronal cultures to study and understand pathological mechanisms under disease conditions.
Asymmetric Diarylethenes with Oxidized 2‐Alkylbenzothiophen‐3‐yl Units: Chemistry, Fluorescence, and Photoswitching
Authors: Uno Kakishi , Bossi Mariano L. , Konen Timo , Belov Vladimir N. , Irie Masahiro , Hell Stefan W.
Published: January 2019

Reversibly photoswitchable diarylethenes (DAEs) with fluorescent closed forms are applied in biology‐ and material science‐related super‐resolution microscopy. Yet, their full photoswitchable capacities remain unrevealed and unexplored. Due to limitations in synthesis, only 1,2‐[bis‐(2‐ethyl‐1‐benzothiophene‐1,1‐dioxide‐3‐yl)]perfluorocyclopentenes with two identical or very similar aryl groups attached to C‐6 and C‐6′ have been prepared so far. DAEs with increased Stokes shifts related to asymmetric structures and the presence of “push–pull” substituents are introduced in the present study, and their switching power is studied. The new “simplified” asymmetric DAEs possess higher cycloreversion quantum yields, but lower emission efficiencies than their known analogs with extended π‐conjugation paths. Fatigue resistance in organic (acetonitrile and methanol) and aqueous solvents is studied, and the performance in reversible saturable optical fluorescence transition (RESOLFT) microscopy is evaluated. The push–pull structures show an outstanding increase in fatigue resistance, compared with a reference (H/H) diarylethene. Fatigue resistances on the order of thousands of cycles have been observed in acetonitrile solutions without exclusion of air oxygen. The structure–property relationships and facile preparation procedures enable rational design of DAEs applicable as photoswitchable fluorescent probes. A new setup and methodology for measuring switching performance of fluorescent DAEs are introduced.
Dungeness crab commercial fishermen's perceptions of injuries inform survey development
Authors: Kincl Laurel , Nery Mara , Syron Laura N. , Bovbjerg Viktor , Jacobson Kaety
Published: January 2019

Introduction

The West Coast Dungeness crab fishery is high‐risk for occupational fatalities. The Fishermen Led Injury Prevention Program (FLIPP) explored this worker population's nonfatal injuries and safety perspectives.

Methods

Focus groups were held along the West Coast to (a) review reported injuries, (b) discuss risk factors, and (c) identify content to inform future FLIPP research activities, including survey development. Focus group data were transcribed and analyzed qualitatively. The FLIPP survey was pilot tested with groups of fishermen before broad distribution.

Results

Nineteen fishermen participated in focus groups and 21 pilot tested the FLIPP survey. These discussions illuminated injury risk perceptions, crews’ current safety provisions, and what survey items would be relevant for fishermen.

Conclusion

To engage fishermen in the process of identifying and developing injury prevention efforts, focus groups, and pilot testing were effective methods for incorporating their ideas into a survey.
Solid tumor screening recommendations in trisomy 18
Authors: Farmakis Shannon G. , Barnes Ann M. , Carey John C. , Braddock Stephen R.
Published: January 2019

The purpose of this study was to determine whether trisomy 18 patients are at an increased risk of tumor development and require formal tumor screening recommendations. A literature search of trisomy 18 patients with reports of tumors or malignancies, and compilation of all previously reported as well as new unreported cases was performed. 67 patients with trisomy 18 were found to have documented malignancies. 44 patients had hepatoblastomas, 21 patients had Wilms tumors, one patient had a functional neurogenic neoplasia, and one patient had Hodgkins lymphoma. The increasing numbers of reported malignancies in patients with trisomy 18 supports the indication for an early screening process. Specific screening recommendations are outlined consisting of imaging exams and laboratory values performed at specific intervals.
Phenotypic spectrum of NDE1‐related disorders: from microlissencephaly to microhydranencephaly
Authors: Abdel‐Hamid Mohamed S. , El‐Dessouky Sara H. , Ateya Mohamed I. , Gaafar Hassan M. , Abdel‐Salam Ghada M.H.
Published: January 2019

Biallelic variants in the NDE1 gene have been shown to occur in extreme microcephaly. Most of the patients displayed microlissencephaly but one with microhydranencephaly. We report on three sibs in which the brain MRI and CT scans demonstrated variable degree of reduced volume of cerebral hemispheres and ventriculomegaly. Further, they had agenesis of corpus callosum, cerebellar, and brainstem hypoplasia. Fetal ultrasound at 32 weeks' gestation of the third sib revealed severe micrencephaly with extensive hydranencephaly and an anomaly consistent with non cleaved (fused) thalami. Because of the fused thalami, the STIL gene was targeted initially but showed negative results. His postnatal MRI showed that the cerebral hemispheres are markedly reduced in size (with no definite frontal, parietal, or occipital lobes) and replaced by a large sac filled with CSF. An intact falx cerebri was identified. This extensive hydarencephaly led us to consider the NDE1 and to identify a novel homozygous nonsense variant (c.54G>A, p.W18*). The variability of the degree of brain malformations and the apparent fusion of the thalami were illusive and delayed the recognition of the genetic etiology. Our results provide the first antenatal description of this rare syndrome. Further, we expand the genetic architecture and the neuroradiologic phenotype of NDE1‐related disorders.
Access to Sulfides through Free Radical Reaction of Vinyl Halides with Thiols
Authors: Shi Zi‐Fa , Xu Li‐Ning , Chen Jie , Luo Hui‐Xing , Zhang Juntao , Cao Xiao‐Ping
Published: January 2019

An efficient radical‐mediated carbon‐sulfur bond formation reaction of vinyl halides with thiols has been developed. This reaction tolerated vinyl chloride substrates, which are barely tolerated in metal‐catalyzed reactions, providing vinyl sulfide products. When vinyl iodides were used as substrates, the reactions were regulated by the solvents, yielding vinyl sulfide products in protic solvents (methanol) and alkyl sulfides in aprotic solvents (toluene).
Zirconium‐β Zeolite‐Catalyzed Continuous‐Flow Friedel‐Crafts Acylation Reaction
Authors: Rao Xiaofeng , Ishitani Haruro , Yoo Woo‐Jin , Kobayashi Shū
Published: January 2019

H‐β Zeolites, doped with various metal salts, were investigated as heterogeneous catalysts for continuous‐flow Friedel‐Crafts acylation reactions. It was found that Zr‐β zeolites possessed excellent catalyst activity and stability, which enabled its use as a catalyst, up to 5 days, for Friedel‐Crafts reactions between various activated arenes and acid anhydrides. Challenging substrates, such as toluene and m‐xylene, were also successfully applied for the continuous‐flow process.
The effectiveness of correction & republication as quality control in scholarly communication – A bibliometric analysis
Authors: Peterson Gabriel M.
Published: January 2019

The practice of correction and republication is a mechanism for identifying and updating non‐maleficent yet message‐distorting errors in the biomedical literature. Inappropriate use of anomalous literature is evinced by citation of invalidated scholarly works, and though it is known that republished versions of articles are cited more often than corrected versions, the strength of the effect of invalidation, correction, and republication has not been previously quantified. Robust analysis of 15,000+ citations to 548 articles indexed in PubMed indicates that the practice of correction and republication is a strong predictor of reduced post‐republication citation relative to controls. This bibliometric analysis shows that corrected articles are cited on average 51% less than controls overall and that the practice of correction and republication results in a fast‐acting and long‐lasting reduction in citation of flawed works by downstream researchers.
Uncovering unintended and shadow practices of users of decision support system dashboards in higher education institutions
Authors: McCoy Chase , Rosenbaum Howard
Published: January 2019

Higher education institutions' (HEI) have begun to develop decision support system data dashboards (DSS‐DD) to improve the data‐informed decision making practices of institutional decision makers. This qualitative study examines the practices of decision makers as they engage with DSS‐DD at a large U.S. Midwestern university and uncovers the socio‐technical characteristics that lead to limited or non‐use of dashboards. To examine these practices and characteristics, this study presents a framework grounded in socio‐technical interaction networks from social informatics and sociomateriality from information systems that explores the socio‐technical practices of users within organizations, while acknowledging the impact of the users' socio‐technical contexts on their DSS‐DD practices. The results show that during the design and implementation phases of these dashboards the institutional contexts that the dashboards are meant to inform are often ignored; and that as users interact with these systems they develop unintended and shadow practices that lead to limited or non‐use of the dashboards for decision making purposes. Additionally, the study finds that users' practices are influenced by their local socio‐technical networks, which includes their prior experiences using institutional data, other actors within their institutional unit, and the political and social contexts which shape the users' decision making behavior and data‐use practices.
The Social Informatics of Ignorance
Authors: Greyson Devon
Published: January 2019

Social informatics researchers use a variety of techniques to explore the intersections between technology and society. Current interest has turned to making more explicit our commonly tacit knowledge processes that involve people and technology. Knowledge creation, sharing, and management processes are commonly hidden, and this is even more the case regarding ignorance processes such as the denial and obfuscation of knowledge. Understanding the construction, generation, and perpetuation of ignorance can: (i) provide insights into social phenomena that might otherwise seem inexplicable (for instance, persistence of “urban myths”), and (ii) enable development of interventions to either facilitate (as with privacy‐sensitive material) or combat (as with malicious disinformation) ignorance. Although several pressing information issues relate to ignorance, agnotology (the study of ignorance) has only recently entered into the information science literature. An agnotologic approach expands the repertoire of methods and approaches in social informatics, better enabling the field to grapple with pressing contemporary issues of mis/dis/lack of information. Using Robert Proctor's typology of constructions of ignorance, this article describes ways that each type may be germane to and within social informatics, highlighting social informatics topics that would benefit from agnotologic exploration, and suggesting theoretical and methodological approaches useful to a social informatics of ignorance.
Stereodivergent Synthesis of Bispyrrolidinoindoline Alkaloidal Scaffolds and Generation of a Lead Candidate with Stereospecific Antiproliferative Activity
Authors: Wada Mitsuhiro , Suzuki Hiroyuki , Kato Mitsuyasu , Oikawa Hideaki , Tsubouchi Akira , Oguri Hiroki
Published: January 2019

The fungal secondary metabolites (+)‐WIN 64821 and (−)‐ditryptophenaline are biosynthesized through condensation of l‐tryptophan and l‐phenylalanine, followed by reductive dimerization with generation of stereochemical variations. Inspired by the stereodivergent biogenetic process, we designed and synthesized a collection of bispyrrolidinoindoline diketopiperazine alkaloids and their analogues with systematic diversification of the stereochemistry of the privileged structural motif of the fungal alkaloids. Not only the stereochemical modifications of (+)‐WIN 64821 at the 3‐/3′‐, 11‐/11′‐, and 15‐/15′‐positions, but also ring cleavage of the diketopiperazine moieties, allowed the generation of a lead compound exhibiting potent growth inhibitory activity (IC50=3.03 μm) toward human colon cancer cells. Structure–activity relationship studies revealed that all six stereogenic centers were essential for the pharmacophore. High cell densities dramatically intensified the cytotoxic activities of the lead compound.
Protrusion of a loop‐shaped 0.035‐inch wire without the fracture of the self‐expanding nitinol stent: A case report and experimental study
Authors: Karashima Eiji , Kawasaki Daizo , Yoda Shunsuke , Yasuda Shioto , Kaneko Takeo
Published: January 2019

Key Clinical Message

We report a case of a loop‐shaped 0.035‐inch wire protruding through self‐expanding nitinol stent struts. Our in vitro experiment suggests that, even if there are no stent fractures, the loop‐shaped 0.035‐inch wire has a potential to protrude through the struts of the self‐expanding nitinol stents.
Mizuo‐Nakamura phenomenon in an Indian male
Authors: Agarwal Rohit , Tripathy Koushik , Bandyopadhyay Gopal , Basu Koushik
Published: January 2019

Key Clinical Message

The authors present a 20‐year‐old myopic male who showed golden color of fundus (Mizuo‐Nakamura phenomenon) in light and normal color after long dark adaptation. This phenomenon is associated with an abnormally slow dark adaptation and is typically noted in Oguchi disease, a variant of congenital stationary night blindness.
Extended Limits of Reversible Electrochemical Lithiation of Crystalline V2O5
Authors: Itkis Daniil M. , Krivchenko Victor A. , Kozmenkova Anna Ya. , Pakhotina Margarita S. , Napolskiy Filipp S. , Gigli Lara , Plaisier Jasper , Khasanova Nellie R. , Antipov Evgeny V.
Published: January 2019

Although lithium intercalation into vanadium (V) oxide was studied over decades, exact compositional stability limits for γ‐LixV2O5 phase, which can be reversibly lithiated and delithiated, are still not clear. Using operando and ex‐situ synchrotron X‐ray diffraction, we traced phase composition of the V2O5 electrodes containing reduced graphene oxide during its lithiation and delithiation. We found that coating of micron‐sized V2O5 particles by reduced graphene oxide yields the material providing electrochemical capacity of more than 300 mA h g−1 manifesting insertion of more than 2 lithium ions per mole of V2O5 as confirmed by ICP MS analysis of the electrodes. The obtained electrode material can be sustainably cycled with capacity retaining at ca. 220 mA h g−1 at 500 mA g−1 current over 200 cycles.
Sliding Polymeric Layers and Anion Displacement Coupled with Spin Crossover in Two‐Dimensional Networks of [Fe(hbtz)2(CH3CN)2](BF4)2
Authors: Książek Maria , Weselski Marek , Ilczyszyn Maria , Kusz Joachim , Bronisz Robert
Published: January 2019

The abrupt high spin (HS)→low spin (LS) transition (T↓1/2=136 K) in [Fe(hbtz)2(CH3CN)2](BF4)2 (hbtz=1,6‐di(tetrazol‐2‐yl)hexane) is finished at 100 K and further thermal treatment influences the spin crossover. Subsequent heating involves a change of the spin state in the same way (T↑1/2=136 K) on cooling. In contrast, cooling below 100 K triggers different behavior and T↑1/2 is shifted to 170 K. The extraordinary structural changes that occurred below 100 K are responsible for the observed diversity of properties. A unique feature of the low‐temperature phase is the rebuilding of the anion network expressed by a shift of anions inside the polymeric layer at a distance of 1.2 Å as well as the relative shift of neighboring layers at over 4 Å. These structural alterations, connected with a phase transition, become the origin of the strain, which in most cases causes crystal cleaving. In a sample composed from crystals crushed as a result of the phase transition or as a result of mechanical crumbling, the hysteresis loop vanishes; however, annealing the sample allows to its partial restoration. A replacement of acetonitrile by other nitriles leads to preservation of the polymeric structure and spin crossover, but no phase transition follows.
Multilevel Coupled Hybrids Made of Porous Cobalt Oxides and Graphene for High‐Performance Lithium Storage
Authors: Hu Chao , Yang Juan , Yu Chang , Li Shaofeng , Mu Ye , Bai Silin , Wang Man , Liang Sucen , Qiu Jieshan
Published: January 2019

Metal oxide coupling with carbon materials holds great promise for lithium storage. Herein, multilevel coupled cobalt oxide–graphene (CoO/CO3O4–G) hybrids were fabricated by in situ assembly of Co hydroxide precursors and a calcination process. The oxygen‐containing functional groups on the graphene surface act as bridging sites and tend to bond with Co2+ ions, effectively modifying the morphology and structure of the Co species. The as‐obtained CoO/CO3O4–G hybrids are composed of unique CoO/CO3O4 porous nanoparticles uniformly anchored on graphene sheets, as confirmed by a series of characterization analyses. Benefiting from these structural characteristics, the CoO/CO3O4–G hybrids used as an anode can deliver a high capacity of about 1080 mA h g−1 reversibly at 0.1 Ag−1 in the voltage range between 3.0 and 0.01 V, which is remarkably superior to that of the CoO hexagonal sheets in the absence of graphene. The high reversible capacity of the CoO/CO3O4–G hybrids is retained at elevated current densities, for example, a capacity of approximately 455 mA h g−1 can be achieved at a current rate as high as 4 A g−1, indicative of its potential for high‐performance lithium‐ion batteries.
Direct Carboxylation of Electron‐Rich Heteroarenes Promoted by LiO‐tBu with CsF and [18]Crown‐6
Authors: Shigeno Masanori , Hanasaka Kazuya , Sasaki Keita , Nozawa‐Kumada Kanako , Kondo Yoshinori
Published: January 2019

We herein demonstrate that the combination of LiO‐tBu, CsF, and [18]crown‐6 efficiently promotes the direct C−H carboxylation of electron‐rich heteroarenes (benzothiophene, thiophene, benzofuran, and furan derivatives). A variety of functional groups, including methyl, methoxy, halo, cyano, amide, and keto moieties, are compatible with this system. The reaction proceeds via the formation of a tert‐butyl carbonate species.
Copper‐Catalyzed Electrophilic Thiolation of Organozinc Halides by Using N‐Thiophthalimides Leading to Polyfunctional Thioethers
Authors: Graßl Simon , Hamze Clémence , Koller Thaddäus J. , Knochel Paul
Published: January 2019

(Hetero)aryl, benzylic, and alkyl zinc halides were thiolated with N‐thiophthalimides at 25 °C within 1 h in the presence of 5–10 % Cu(OAc)2⋅H2O to furnish the corresponding polyfunctionalized thioethers in good yields. This electrophilic thiolation was extended to the introduction of trifluoromethylthio (SCF3), thiocyanate (SCN), and selenophenyl (SePh) groups. The utility of this method was shown in a seven‐step synthesis of a potent cathepsin D inhibitor in 34 % overall yield.
Exploration of New Birefringent Crystals in Bismuth d0 Transition Metal Selenites
Authors: Gong Ya‐Ping , Hu Chun‐Li , Kong Fang , Mao Jiang‐Gao
Published: January 2019

The first examples of bismuth fluoride selenites with d0‐TM/TeVI polyhedrons, namely, Bi4TiO2F4(SeO3)4 (1), Bi4NbO3F3(SeO3)4 (2), Bi4TeO4F2(TeO3)2(SeO3)2 (3), Bi2F2(MoO4)(SeO3) (4) and Bi2ZrO2F2(SeO3)2 (5) have been successfully synthesized under hydrothermal reactions by aliovalent substitution. The five new compounds feature three different types of structures. Compounds 1–3, containing TiIV, NbV and TeVI respectively, are isostructural, exhibiting a new 3D framework composed of a 3D bismuth oxyfluoride architecture, with intersecting tunnels occupied by d0‐TM/TeVI octahedrons and selenite/tellurite groups. Interestingly, compound Bi4TeO4F2(TeO3)2(SeO3)2 (3) is the first structure containing SeIV and mixed‐valent TeIV/TeVI cations simultaneously. Compound 4 features a new 3D structure formed by a 3D bismuth oxyfluoride network with MoO4 tetrahedrons and selenites groups imbedded in the 1D tunnels. Compound 5 displays a novel pillar‐layered 3D open framework, consisting of 2D bismuth oxide layers bridged by the [ZrO2F2(SeO3)2]6− polyanions. Theoretical calculations revealed that the five compounds displayed very strong birefringence. The birefringence values of compounds 1–3, especially, are above 0.19 at 1064 nm, which are larger than the mineral calcite. Based on the structure and property analysis, it was found that the asymmetric SeO3 groups (and TeO3 in compound 3) displayed the largest anisotropy, compared with the bismuth cations and the d0‐TM/Te polyhedra, which is beneficial to the birefringence.
Thermodynamic and kinetic performance of an S2O82‐/CaO2 solution for NO removal
Authors: Wang Zhiping , Zhang Yanguo , Tan Zhongchao , Li Qinghai
Published: January 2019

The thermodynamic and kinetic performance of the oxidative absorbent S2O82‐/CaO2 for NO removal was evaluated. The results indicated that the optimal molar ratio of Na2S2O8/CaO2 was 0.1:0.2 mol/mol. The experimental results showed that the combination of Na2S2O8 and CaO2 had a positive synergistic effect on the NO removal. The results of the thermodynamic calculation verified that the use of the oxidative absorbent S2O82‐/CaO2 was effective for NO removal. The results of the kinetic study showed that the NO reaction was a 1.1‐order equation and the average activation energy of the reaction was 53.0 kJ/mol. The oxidative absorbent S2O82‐/CaO2 shows potential for the simultaneous wet removal of NO and SO2 with high efficiency, no secondary pollution, and low cost.
New efficient tool diagnoses asphaltene stability: Utilization of refractive index
Authors: Ahmadi Mohammad Ali , Zendehboudi Sohrab
Published: January 2019

Asphaltene precipitation/deposition is considered a critical issue in the petroleum industry as it causes damages and blockage in various process equipment (e.g., pipe, pump, and vessel) and porous formation. To prevent this obstruction, it seems necessary to attain a reasonable estimate of the precipitation time, in other words, the time of asphaltene stability in crude oils. The gene expression programming (GEP) technique is utilized in this study to develop a correlation for the prediction of this important parameter using real refractive index (RI) data. The independent variables considered for the development of the correlation are the composition of aromatics, saturates, and resins in weight percentage. The predicted outputs show a better match with the real data, compared to the results obtained from other available predictive tools and/or correlations. Besides its simplicity, the developed correlation can have a broad range of applications in oil production plants in order to ensure that proper strategies are determined to avoid asphaltene precipitation/deposition throughout various stages of oil production and processing.
Production‐limited delayed detached eddy simulation of turbulent flow and heat transfer
Authors: Ding Puxian , Wang Shuangfeng , Chen Kai
Published: January 2019

A hybrid RANS/LES model based on the BSL k‐ω RANS model, termed the production‐limited delayed detached eddy simulation (PL‐DDES) model, was developed for simulating turbulent flow and heat transfer. The PL‐DDES model was obtained by limiting the production of turbulence kinetic energy with the proposed control resolution function. The PL‐DDES model was tested by simulating turbulent flow and heat transfer in a plane and a wavy channel with different thermal boundary conditions and different Reynolds numbers in this paper. The results of the plane channel flow show that the performance of the PL‐DDES model is better than that of the improved delayed detached eddy simulation (IDDES) model for alleviating the log‐law layer mismatch (LLM) issue. With a much coarser grid resolution, although the resolved turbulent scales decrease, the time‐averaged velocity and temperature are successfully predicted. The capability of predicting turbulent flow and heat transfer over a wavy wall manifests, and the PL‐DDES model has considerable potential in industrial and environmental applications.