bluuebunny/crossref_metadata_2025 huggingface dataset:
Copper and lead as environmental pollutant and their elemental toxicity – a review
Authors: Abubakar Usman Sadiq
Published: August 2024

Pollutants are substances in the environment with potential objectionable effects leading to impairment of the welfare of environment, interfering with the quality of life that may eventually result to the organisms being affected. The aim here was to give summary of the review of the toxicity of Copper and Zinc as pollutants in the environment, be it air, water or soil, which may be poisonous and will cause harm to living organisms in the polluted environment. The elemental concentration of sediment therefore and its bioavailability not only depends on anthropogenic and lithogenic sources, but also on organic matter, physical (textural) characteristics as well as mineralogical composition and depositional environment of sediments. Copper causes toxicity and hazards in flora, fauna and human beings. It causes a disease called ‘Wilson’s disease. Excessive exposure to Cu may cause haemolysis, hepatotoxic and nephrotoxic effects. Mucosal irritation, corrosion, widespread capillary damage, hepatic and renal damage and central nervous system irritation are some of the dysfunctions consequent to Cu exposure. Among the various means through which lead toxicity occurs are; the ionic mechanism and the oxidative stress. Several studies indicated that oxidative stress in living cells is caused by the imbalance between the production of free radicals and the generation of antioxidants to detoxify the relative intermediates or to repair the resulting damage.
„Na ratunek dzieciom” – ochronka przy lubelskim Związku Kobiet Żydowskich w świetle lubelskiej prasy jidysz z okresu międzywojennego
Authors: Kubiszyn Marta
Published: August 2024

Previous research regarding the culture and history of the Jewish community in Lublin in the interwar period only to a small extent covered issues related to the nurseries for Jewish children. Since little archival documentary material is available, texts published in Lublin’s Yiddish press in the 1920s and 1930s serve as a valuable source. The article discusses particular aspects regarding the nursery run by the Zionist Association of Jewish Women which had its headquarters at 41 Krawiecka Street, in the middle of the Podzamcze Jewish district of Lublin. Analyzing articles written by Bela Dobrzyńska, a local Zionist activist who was also a co-founder of the nursery, as well as other texts, the author discusses issues regarding educational work carried out by this institution. A broader interpretative and comparative context for the analysis is provided by press articles regarding the orphanage for Jewish children at 11 Grodzka Street run by the Jewish community, as well as by studies on pedagogical ideas developed in the nineteenth and early twentieth centuries.
„Skarb i przyszłość narodu”. Polityka organizacji żydowskich w Lublinie wobec młodzieży w latach 1944–1968
Authors: Klimowicz Teresa
Published: August 2024

The purpose of this article is to present the policy toward Jewish youth carried out by the main Jewish institutions operating in Lublin in the postwar period (until 1968), including the local representation of the Central Committee of Polish Jews (CKŻP) (1945–1950) and the Lublin branch of the Social and Cultural Society of Jews in Poland (TSKŻ), as well as the activities of local Zionist youth organizations. The paper presents the organizational structures of the youth-specialized units operating within the aforementioned institutions, the formal and personal changes within them, as well as the local particularities of their activity. The ideological assumptions of these organizations are analyzed and set in the context of the cultural debate over the possibility of rebuilding Jewish life in Poland: nusekh Poyln and yetsiyes Poyln.
Wizerunek „talusza” w twórczości Icchaka Dowa Berkowicza
Authors: Jaworska Agata
Published: August 2024

In 1904, Yitskhok-Dov Berkovitz published the short story “Talush.” This term came to describe the literary portrayal of a man torn from his natural environment—a theme prevalent in Hebrew prose during that era. Talush evolved into a metaphor for Jews from the diaspora navigating the delicate balance between tradition and the progressive secularization of their world. Scholars, including Gershon Shaked and Avraham Holtz, categorize Berkovitz’s protagonists as “uprooted.” This article aims to compare the destinies of protagonists from previously unexamined stories: “Moshkeli-Hazir,” “Mi-Merhakim,” and “Koah ha-dimyon.” The objective of the author is to assess the extent of their rootlessness and alienation, demonstrating that these character types differ. The analysis of the stories proves that not all of them can be classified as talush.
Diagnosing the stability of large-scale processes using fractal structure analysis of time series
Authors: Abelashvili Nodar , Otkhozoria Nona , Otkhozoria Vano , Akhlouri Eka
Published: August 2024

This paper aims to study large-scale processes that persist over time to describe their stability, and to monitor and diagnose negative changes. By utilizing fractal structure analysis of time series, the research investigates the applicability of the Hurst exponent in diagnosing the stability of various natural and man-made systems. The findings highlight the limitations of standard Gaussian statistics and the effectiveness of fractal analysis in revealing hidden patterns and long-term dependencies in complex systems.
Аналіз способів визначення гранулометричного складу пульпи на виході кульового млина ультразвуковим методом та підвищення ефективності шляхом врахування зміни концентрації пульпи
Authors: Харламенко Вадим Юрійович , Лазарєв Віталій Сергійович
Published: August 2024

Подрібнення руди на гірничозбагачувальному комбінаті, що використовує кульові млини, є ключовим етапом у виробництві чорних металів. Цей процес характеризується високою ресурсоємністю та впливає на якість подальшої обробки. Впровадження сучасних інформаційних технологій для автоматизації прийняття рішень під час ремонту та управління дозволяє підвищити ефективність використання обладнання та знизити економічні витрати. Насьогодні існують методи ультразвукового дослідження гранулометричного складу пульпи на виході кульового млина що описані в ряді наукових досліджень, але такі методи, незважаючи на свою перспективність, не знайшли широкого застосування через низку проблем, які необхідно виокремити для подальших досліджень. Одним із таких методів є метод визначення гранулометричного складу пульпи на виході кульового млина. Ультразвуковий метод дослідження пульпи заснований на аналізі відбиття та розсіювання ультразвукових хвиль різної частоти при проходженні через суспензію. Цей метод дозволяє в реальному часі отримувати дані про розподіл розмірів часток, забезпечуючи точний і оперативний контроль процесу подрібнення. Серед переваг методу – висока чутливість до змін гранулометричного складу та можливість безперервного моніторингу. Впровадження ультразвукових систем для контролю пульпи сприяє оптимізації режимів роботи кульового млина, зниженню енергоспоживання та покращенню якості продукту. Однак існує низка проблем, які обмежують широке впровадження ультразвукового методу. Серед основних проблем – висока вартість обладнання та необхідність його регулярного калібрування. Крім того, точність вимірювань може бути знижена через наявність бульбашок повітря в пульпі, варіації у складі та концентрації твердої фази, а також через можливе забруднення датчиків. Інтерпретація отриманих даних потребує високої кваліфікації персоналу та спеціалізованого програмного забезпечення. Подальші дослідження спрямовані на вирішення цих технічних проблем, зниження вартості систем та інтеграцію з іншими автоматизованими системами управління виробничими процесами.
Перспективні напрямки забезпечення надійності радіоелектронних засобів
Authors: Глухов Сергій Іванович , Сакович Лев Миколайович , Бабій Олександр Сергійович
Published: August 2024

В статті на основі аналізу сучасних наукових публікацій встановлено та досліджено перспективні напрямки забезпечення надійності сучасних програмно-керованих радіоелектронних засобів. Вперше розглянута можливість появи і накопичення прихованих дефектів в багаторежимних об'єктах, а також під час їх короткочасного зберігання. Комплексно враховано діагностування аналогових і цифрових частин виробу під час поточного ремонту. Формалізовано порядок забезпечення потрібних значень показників надійності сучасних радіоелектронних засобів як під час проектування, так і в процесі експлуатації з врахуванням можливості появи і накопичення прихованих дефектів. Також вперше формалізований порядок оцінки середнього часу відновлення виробів після короткочасного зберігання. Отримані наукові дослідження доведено до можливості практичного використання із застосуванням інформаційних технологій.
Generalized Stochastic Model of Long-Term “Cap” and “Prudent” Value Estimation
Authors: Yakubovsky Valery , Bychkov Oleksiy , Zhuk Kateryna
Published: August 2024

The objective of this study is to analyze existing approaches to the effect of property value fluctuations over time and develop an analytically based approach to consider its significant role. Samuelson’s Rational Theory of Warrant Pricing is used as the theoretical foundation for estimating upper (“cap”) and lower (“prudent”) property values. Analytical decisions received for the estimation of correction parameters necessary to arrive with a certain level of reliability to both the upper and lower bound of property value stochastically evolving over time. The practical application of the developed generalized methodology is demonstrated using an available residential property database. A generalized analytical approach for estimating property value lower and upper bounds is proposed and tested, combining initial market value, its general trend over time, volatility level, and required estimation reliability. The study investigates the role of these main parameters in determining the property value bounds. This research presents and describes a novel stochastic, analytically based methodology for estimating the evolving lower and upper bounds of property values over time. The results significantly contribute to existing methodologies for estimating both “prudent” and “cap” property value levels. The model development, testing, and results analysis are based on a residential property market dataset.
Особливості та роль комунікацій у закладах охорони здоров’я
Authors: Мирута Наталія
Published: August 2024

стаття висвячує важливість та особливість комунікацій у медичній сфері. Досліджено характеристики комунікації «заклад охорони здоров’я – пацієнт», що формуються та застосовуються при різних підходах до надання медичної допомоги, а саме при патерналістичному та пацієнторієнтованому. Виявлено, що вони відрізняються за наступними характеристиками: мета комунікації «заклад охорони здоров’я – пацієнт», завдання закладу охорони здоров’я, тип відносин «лікар-пацієнт», моделі спілкування «лікар-пацієнт», принципи комунікацій «лікар-пацієнт», наявність зворотного зв’язку «заклад охорони здоров’я – пацієнт», комунікаційні канали передачі повідомлень, засоби комунікації, роль комунікації у діяльності закладу охорони здоров’я, визначення комунікації. За результатами дослідження побудовані схеми комунікацій при різних підходах до надання медичної допомоги. При патерналістичному підході комунікація будується на основі класичних процесів та включає такі етапи: опитування лікарем пацієнта щодо скарг на стан здоров’я, формулювання, кодування та передача лікарем повідомлення – рекомендації щодо вирішення проблем зі станом здоров’я, отримання та декодування повідомлення – рекомендацій пацієнтом, оцінка зрозумілості повідомлення – консультації пацієнтом, виконання рекомендацій. При пацієнторієнтованому підході комунікація включає більш розширений перелік етапів, а саме: виявлення лікарем намірів, релігійних та ін. уподобань пацієнтів, визначення лікарем мети комунікації, опитування лікарем пацієнта щодо скарг на стан здоров’я, формулювання лікарем повідомлення – інформації щодо варіантів шляхів вирішення проблеми зі станом здоров'я, кодування лікарем сформованого повідомлення – інформації у доречний для пацієнта формат, передача лікарем повідомлення – інформації через адекватний, доступний, вагомий та привабливий для пацієнта канал, отримання та декодування пацієнтом отриманого повідомлення – інформації, обговорення лікаря з пацієнтом варіантів шляхів вирішення проблеми зі станом здоров'я та обрання одного у відповідності до намірів, релігійних та ін. уподобань пацієнта, формулювання, кодування та передача лікарем повідомлення – рекомендації щодо вирішення проблем зі станом здоров’я згідно обраному варіанту, отримання та декодування повідомлення – рекомендацій пацієнтом та виконання рекомендацій.
Exploring the Use of Student–Professional Simulation-Based Interprofessional Education: A Preliminary Qualitative Study
Authors: Andrea Catherine M. , Lucas Summer San , Anne Boddy Anne Boddy
Published: August 2024

Introduction: Simulation is commonly used to address interprofessional learning within healthcare programs to develop practice-ready clinicians. However, barriers such as scheduling, and discrepancy of learners’ knowledge and attitudes often pose challenges for educators to implement student-student (S-S) simulation-based interprofessional education (IPE). This study explored student perceptions about a novel simulation-based IPE mode in which students were paired with professionals from other disciplines.

Methods: The qualitative study explored 14 Doctor of Physical Therapy (DPT) students’ perceptions about a simulated-learning activity with professionals from other disciplines. One-on-one semi-structured interviews with students from two private universities were analyzed using a constant comparative method to determine essential themes.

Results: Four main themes emerged from the student experiences: (1) guiding students in professional communication, (2) fostering interprofessional collaboration through a trusted experience, (3) realistic simulation to prepare for future clinical application, and (4) students value professional expertise in a simulated learning experience.

Discussion: Students expressed positive perceptions about student-professional (S-Pr) simulation-based IPE. Student-professional simulation-based IPE may provide new opportunities that advance learning outcomes and increase engagement while minimizing barriers of other modes of IPE. Comparison between S-S and S-Pr modes is needed to determine efficacy and best practices.
Mundo digitais na sala de aula: explorando tablets no ensino fundamental
Authors: Magali Santos Vieira Fábia , Souza Duarte Bianca
Published: August 2024

Mundos Digitais na Sala de Aula: explorando o uso de tablets no Ensino Fundamental. Convidamos você a embarcar em uma jornada pelo fascinante mundo da tecnologia e educação, onde a combinação da sala de aula tradicional com as incríveis possibilidades dos tablets promete revolucionar nosso modo de ensinar e aprender. Este livro tem como objetivo principal apresentar sugestões práticas sobre como incorporar os tablets ao processo de ensino-aprendizagem do Ensino Fundamental e, como objetivos específicos, explorar a forma como eles estão contribuindo para transformar o cenário educacional, proporcionando oportunidades para o desenvolvimento dos estudantes, além de mostrar de perto como as Tecnologias Digitais de Informação e Comunicação (TD) podem ser aliadas poderosas na busca por um ensino mais envolvente, dinâmico e interativo.
Reflections of future Mathematics teachers on Financial Education: perspectives for Basic Education
Authors: Cantareira Ana Beatriz Paiva , Hartmann Andrei Luís Berres , Malheiros Ana Paula dos Santos
Published: August 2024

Since the publication of the Base Nacional Comum Curricular (National Common Curricular Base), Financial Education has become a topic to be developed in the classroom, mainly related to the mathematics curriculum. In this sense, teachers are in charge of addressing it. In view of this, in this paper we aim to discuss understandings of Financial Education aimed at Basic Education and produced by mathematics undergraduates, mobilized in two training meetings. Based on Critical Mathematics Education and the qualitative research paradigm, we identified five topics using content analysis procedures. The results of the analysis of these topics indicate that the future teachers have knowledge of School Financial Education, although they relate the subject to economic aspects and Financial Mathematics.
Critical Financial Education in the interdisciplinary context in Science and Mathematics studies
Authors: Marinho Fabio Cardoso , Pinto Gisela Maria da Fonseca
Published: August 2024

The aim of this study is to present a theoretical essay that integrates Mathematics Education, Financial Education and Critical Environmental Education to weave together, in an interdisciplinary way, strategies that give students access to fundamental skills, with a view to a healthy relationship between consumption, dealing with finances, decision-making and socio-environmental and socio-economic issues. From the studies presented, it was possible to highlight the relationship between environmental impacts, the lifestyle of the citizen-consumer and Critical Education, signaling healthy options for learning to take place more effectively, with possibilities for better harmony between individuals and the environment, through practical actions to build a more balanced society.
Análise da produção escrita de futuros professores de Matemática a partir de uma tarefa de Letramento Financeiro do Pisa
Authors: Ribeiro Raíssa Gomes Freitas , Silva Gabriel dos Santos e
Published: August 2024

O objetivo deste artigo é apresentar uma análise da produção escrita de estudantes de uma disciplina do curso de Licenciatura em Matemática, a partir de uma tarefa de Educação Financeira. Para tanto, selecionou-se uma tarefa do Programa Internacional de Avaliação de Estudantes (Pisa) denominada Ações. Mediante uma adaptação, foram investigadas as resoluções de 10 estudantes do curso de Licenciatura em Matemática da Universidade Federal do Paraná, por meio da análise da produção escrita. Observa-se que os estudantes mobilizaram aspectos do Letramento Financeiro, conforme definido pelo Pisa. No entanto, suas produções escritas não são suficientes para fornecer uma visão completa de como essa mobilização ocorreu.
Safety Assessment on the Safety and Efficacy of an Additive of 25-Hydroxycholecalciferol (Bio D® 1.25%) as a Feed Additive for Poultry for Fattening, Other Poultry (Layers, Broiler, Breeders), Ornamental Birds and All Pigs (RP1335)
Authors: Food Standards Agency  , Food Standards Scotland
Published: August 2024

An application was submitted to the Food Standards Agency (FSA) in November 2021 from Huvepharma NV (‘the applicant’) for the authorisation of 25-hydroxycholecalciferol (Bio D® 1.25%) as a feed additive under the category of ‘nutritional’ additives, functional group ‘vitamins, pro-vitamins and chemically well-defined substances having similar effect’. The additive contains a minimum of 1.25% 25-hydroxycholecalciferol and seeks authorisation for a modification of its production process using Pseudonocardia autotrophica M301 (DSM 32858) as a production organism, and to be used at a maximum dose of: 100 µg/kg, 80 µg/kg, 50 µg/kg of complete feed with 12% moisture in poultry for fattening, other poultry and pigs, respectively; 50 µg/kg, 40 µg/kg, 25 µg/kg in drinking water in poultry for fattening, other poultry and pigs, respectively.

The FSA/FSS concluded the additive and production strain were correctly identified. It is not a dusty product, however the particle size distribution was not characterised fully. The additive is stable for 24 months at room temperature and acceptably stable in premixtures and feed. Stability during pelleting could not be determined. Homogeneity in feed was demonstrated. The presence of live cells from the production organism in the final form of the product could not be ruled out.

The FSA/FSS cannot conclude on the safety of the additive Bio D® 1.25% for the target species and consumers as currently formulated when produced by P. autotrophica M301 (DSM 32858).

The additive is not a skin irritant or sensitiser and is not an eye irritant. The additive has a low dusting potential which would limit exposure through inhalation, however, uncertainties remain on its particle size distribution. Conclusions could not be drawn on the systemic toxicity potential of the additive, and the presence of live cells from the production strain in the final product could not be ruled out. These factors pose a concern for the safety for the user/worker.

The additive can be considered safe for the environment.

25-hydroxycholecalciferol can be considered efficacious for the target species at the proposed doses of inclusion. Conclusions on chickens for fattening can be extrapolated to ornamental birds.

This Safety Assessment represents the opinion of the FSA and FSS.
Safety Assessment on the Safety and Efficacy of an Additive of Enterococcus faecium DSM 2121913, Bifidobacterium ⁠animalis spp. ⁠animalis DSM 16284 and Ligilactobacillus salivarius DSM 16351 (Biomin® C3) as a Feed Additive for Its Use in All Poultry Species for Fattening and Reared for Laying/ Breeding (RP1603)
Authors: Food Standards Agency  , Food Standards Scotland
Published: August 2024

An application was submitted to the Food Standards Agency in June 2022 from BIOMIN GmbH (‘the applicant’) for the renewal authorisation of an additive consisting of Enterococcus faecium DSM 21913, Bifidobacterium animalis ssp. animalis DSM 16284 and Ligilactobacillus salivarius DSM 16351 (Biomin® C3), under the category of ‘zootechnical additive’ and functional group ‘gut flora stabiliser’ for its use in chickens for fattening, chickens reared for laying and minor poultry species other than laying and for the extension of use of the additive under the same category for its use in all poultry species for fattening and reared for laying/breeding. The additive is proposed to be used at a minimum inclusion rate of 1 × 108 CFU/kg in complete feed or 5 × 107 CFU/L in drinking water.

The FEEDAP Panel concluded that Biomin® C3 remains safe for chickens for fattening, chickens reared for laying, and minor poultry species other than laying, as well as for consumers and the environment, under the authorized conditions of use.

The Panel concluded that extending the use of the additive to all poultry for fattening and reared for laying/breeding is safe for the target species, consumers, and the environment. The additive is efficacious at a minimum inclusion level of 1 × 108 CFU/kg in complete feed and 5 × 107 CFU/L in water.

The additive should be considered as a potential respiratory sensitiser but as non-irritant to eyes and skin. Conclusions could not be drawn on the potential to cause skin sensitisation.

FSA/FSS has reviewed the applicant’s renewal and extension of use application, supporting documentation, and other regulators risk assessments, most notably the EFSA risk assessment opinion and consider sufficient evidence has been demonstrated to conclude without further questions or risk assessment. This document represents the opinion of the FSA and FSS.
Edukasi Deteksi dan Pencegahan Skabies Kader Puskesmas Pondok Kacang Timur Tangerang Selatan
Authors: Farida Mustifah Etty , Nurusshofa Zahra , Muhammad Khadafi David , Amay Puspita Dinda , Lawuny Hayati Siti
Published: August 2024

Menurut WHO (World Health Organization) terdapat sekitar 300 juta kasus skabies di dunia setiap tahunnya. Insiden skabies di Indonesia masih sangat tinggi, terendah di Sulawesi Selatan dan tertinggi di Jawa Barat. Prevalensi skabies di puskesmas seluruh Indonesia pada tahun 2008 adalah 5,6%-12,95% dan skabies menduduki urutan ketiga dari 12 penyakit kulit tersering. Penelitian ini bertujuan untuk meningkatkan pengetahuan dan keterampilan kader Puskesmas dalam mengidentifikasi dan mencegah skabies di masyarakat. Metode penelitian ini menggunakan pendekatan kuantitatif dengan desain penelitian eksperimen untuk mengevaluasi efektivitas edukasi mengenai deteksi dan pencegahan skabies pada kader Puskesmas Pondok Kacang Timur Tangerang Selatan. Penelitian ini menunjukkan adanya peningkatan pengetahuan yang signifikan mengenai skabies pada kader Puskesmas Pondok Kacang Timur Tangerang Selatan setelah mengikuti program edukasi. Dengan melibatkan 59 kader, hasil pretest menunjukkan rata-rata nilai sebesar 40, sedangkan posttest meningkat menjadi 73,6, mengindikasikan perbaikan yang substansial dalam pemahaman mereka.
Edge-Magic Total Labeling on Vertex Amalgamation Graphs of a Star Graph with a Path Graph
Authors: Suwandi Selfa , Nurdin Nurdin , Nur Muh.
Published: August 2024

One of the topic graph theories is graph labeling. Let  be a finite simple connected graph, a bijection  from  to  where  and  is called an edge-magic total labeling of  if there exists a contant (called the magic sum of ) such that  for any edge  of . The super edge-magic total labeling on a graph  is the edge-magic total labeling which maps  into the set . Let  be a connected graph with a fixed vertex . The vertex amalgamation of graph  onto a fixed vertex  called terminal denoted by  is a graph formed by taking all elements (vertices and edges) in  with . In this study, we will show that vertex amalgamation graphs of a star graph with a path graph are edge-magic total and super edge-magic total labeling, with constructed vertex labelings and edge labelings to obtain intervals of the magic sums .
Critical Review of the Journey of Democracy in Indonesia: Functions and Authorities of the Regional Representative Council (DPD) in the Constitutional System
Authors: Dorisara Maximus
Published: August 2024

The aim of this research is to analyze and explain the function and authority of the Regional Representative Council (DPD) in the Indonesian constitutional system and to see objectively how the function and authority of the Regional Representative Council (DPD) is implemented according to the Indonesian constitution. This research uses descriptive normative law to explain the function and role of regional representative bodies in the constitutional system. Normative legal research only uses literature studies to collect data.
Design and Implementation in Frontend Development of the PLN UP3 Yogyakarta SIBER Project with Tailwind and Bootstrap
Authors: Septina Annisa Dinda , Ramadhani Erika
Published: August 2024

In the Society 5.0 era which is characterized by mobility high and integration technology in everyday life, PLN UP3 Yogyakarta experienced operational obstacles, especially related to manual data processing and static websites. To overcome these challenges, a Joint Information System (SIBER) was developed as an application web- based which allows real-time data access for all employees. In SIBER development, the Scrum method is used for possible project management clear planning and flexibility in sprint iterations. In addition, the implementation of the Tailwind CSS framework and Bootstrap in the development of the SIBER user interface ensures a responsive and attractive appearance, with Tailwind providing detailed design flexibility and Bootstrap providing UI components that are tested and easy to use.
Comparative Analysis of the Crime of Overspel (Adultery) in the Articles of the New Criminal Code and the Old Criminal Code Related to Adultery
Authors: Wahyumah Ida , Saputra Trias
Published: August 2024

Law in Indonesia is still largely influenced by Dutch law, both in terms of legal logic, legal concepts and theories. One of them is the regulation of the crime of adultery which is regulated by Article 284 of the Criminal Code. This setting is considered no longer relevant so it must be updated. The Criminal Code has reformed articles that are no longer in accordance with Indonesian culture. one of which is Article 411 concerning adultery which has been adapted to the norms and culture that apply in Indonesia. The problem taken from this research is a comparative analysis of the crime of overspel (adultery) in the articles of the new criminal code and the old criminal code related to adultery. The research method used in this research is Normative Juridical with the approach used being a statutory approach by analyzing the provisions contained in Articles 284 of the Criminal Code and 411 of the Criminal Code, research sources namely by law, secondary legal sources with scientific articles and books, tertiary book materials with dictionaries. The method of collecting legal materials with reference sources related to research, and the method of analyzing legal materials by understanding and reviewing the data collected. The results of the research concluded that the aim of updating the adultery article in the Criminal Code includes a value reorientation that attempts to accommodate the Indonesian value system in the offenses of adultery and cohabitation in the Criminal Code whose philosophy is in the form of safeguarding and respecting the institution/institutions of marriage, lineage, and upholding the values of marriage. moral values contained in Indonesian society. The aim of this research is to find out the comparison of the adultery article in article 284 of the old Criminal Code. and article 411 of the new Criminal Code. The changes to the adultery article in the Criminal Code are in accordance with the culture and norms that apply in Indonesia.
Revisão sobre energia relativística no espaço-tempo contínuo de 4-dimensões de Minkowski
Authors: Meira Filho Damião Pedro , Silva Guilherme Damasceno , Monteiro Nayra Gabryelle Silva , Lima Pedro Dimas da Cunha , Silva Jakelyne Machado Lima , Moutinho Pedro Estevão da Conceição , Nascimento Leonardo Oliveira do , Kamassury Jorge Kysnney Santos
Published: August 2024

Objetivo: A teoria da relatividade especial ou teoria da relatividade restrita de Einstein admite que os fenômenos físicos de maneira geral bem como qualquer sequência de eventos encenam e ocorrem em um espaço-tempo contínuo e plano de quatro-dimensões classificado como espaço-tempo contínuo de Minkowski, sendo possível estabelecer grandezas tensoriais de ordem-0, ordem-1 e ordem-2, grandezas estas capazes de descrever a evolução de sistemas bem como realizar transformações entre sistemas de referência. Este trabalho de revisão de conteúdo dedica-se a detalhar alguns aspectos da estrutura da energia relativística total com base na apresentação algébrica do tensor de posição, tensor de velocidade, tensor de momento linear em quatro-dimensões dando ênfase às relações entre componentes covariantes e contravariantes. Durante a última subseção calcula-se a expressão de energia relativística total bem como analisa-se a energia total sob contexto de regime de relatividade de Galileu ou regime do tipo não-relativístico, usufruindo do método de expansão em série infinita de Taylor seguido de plotagem e análise do comportamento da curva da energia total  e do fator de Lorentz ambos em termos de .
Image Guided Minimally Invasive Internal Fixation Pilon Fracture with Distraction Arthroplasty
Authors: Slater Gordon
Published: August 2024

The article explores a case of a 28-year-old woman who sustained a closed comminuted pilon fracture with a segmental fibula fracture after a horse-riding accident. Treatment consisted of Open Reduction and Internal Fixation (ORIF) using a minimally invasive image guided technique with distraction arthroplasty to promote cartilage healing and PRP injections. The patient’s initial recovery was complicated by persistent pain and nerve compression. X-rays showed bony union after a year. Within this time the ankle’s range of motion had improved from the initial surgery (60% compared to the other ankle). Ultimately, she was able to return to work, although can competitively horse ride again with some limitations. Overall, the combination of ORIF and distraction arthroplasty for this comminuted fracture is a safe and effective treatment with successful outcomes currently. We believe this case highlights principles to be used in joint regenerative surgery.
Efficacy and Tolerability of an Advance Face Night Cream in Reducing Facial Pigmentation and Wrinkles in Women
Authors: Choudhary Sanjay
Published: August 2024

Background: The efficacy and tolerance of Advance Face Night Cream in reducing facial pigmentation and wrinkles in women was evaluated.

Methods: This was a monocentric, single-group, comparative, open-label study involving healthy adult women with mild to-moderate wrinkles and at least one pigmented spot on the face. The Advance Face Night Cream was to be applied every night before bedtime along with sunscreen lotion (with sun protection factor [SPF] 50) during the day. Evaluations included clinical examination and grading of wrinkles in the crow’s feet area, nasolabial region, forehead and under the eyes. Skin lightening and skin hydration effects along with subjective efficacy were also evaluated.

Results: Thirty-three women completed the study (mean age: 44.03±5.41 years). A significant decrease in the mean score of wrinkles in the crow’s feet area (7.5%; p=0.004) and on the forehead and under-eye region (12.5%; p=0.001) was noted at 45 days. The 3-dimensional imaging revealed a significant decrease in the mean overall size of wrinkles after 21 and 45 days (10.0% and 9.0%; p=0.002 and p=0.003, respectively) and the mean width of wrinkles (3.5% and 4.4%; p=0.007 and p=0.001, respectively). Comparable benefits in skin radiance, color and hydration were noted at both 21 and 45 days. Other benefits included improved skin moisture, reduced visible pigmentation and wrinkles and improved overall skin appearance.

Conclusion: The topical application of Advance Face Night Cream and the appropriate usage of sunscreen lotion with SPF 50 led to a significant reduction in fine lines and the overall size and width of facial wrinkles in 3 and 6 weeks. The cream could significantly hydrate the skin, brighten the skin tone and lighten the skin color of the pigmented area in 3 weeks. No adverse events were reported by any participant during the study.
After Math of COVID Through Eyes of Tricoscopy
Authors: Madarka Mahajabeen
Published: August 2024

Background: Across the globe from December 2019 until today (COVID -19) has rapidly spread causing pandemic. We have obsevered acute hair loss (TE) in intiating 3-4 months of post COVID infection. Telogen effluvium is a diffuse, non scarring shedding of hairs, resulting from the early entry of the hairs into the telogen phase. Classic TE is self limited and acute, defined as lasting less than 6 months. Trichoscopy is a simple and non invasive technique that can be performed with both handheld dermatoscope and digital videodermoscopy system. Trichogram is simple minimally invasive rapid and economic technique for measuring hair follicle activity.

Objective: To assess hair loss occurring after COVID-19 infection. The aim of our study is to assess hair loss occurring after COVID-19 infection using trichoscopy and trichogram to investigate the possible findings related to COVID 19 infection.

Materials and Methods: Prospective, observational study included 80 patients with post COVID TE.

Results: Out of 80 patients, hairpull test was positive in 63%. Trichogram parameters showed positive telogen effluvium in 70 patients (as the rate was more than 20%) with anisotrichosis.

Conclusion: In the current era, SARS-CoV-2 infection should be suspected in a patient who presents with acute TE. This study shows some variations in the trichoscale as hair density had significantly decreased in 70 patients. Dermoscopic features suggested of peripilar sign, yellow dots, anisotrichosis and perifollicular scaling as the diagnostic criteria.
Piodermatite-Pioestomatite Vegetante: relato de caso e revisão de literatura
Authors: Roldão Juliana de Assis , Saad Victoria Lemos de Almeida , Campos Gabriela Oliveira , Leal Lara Sousa
Published: August 2024

Introdução: A piodermatite-pioestomatite vegetante (PD-PSV) é uma doença mucocutânea rara caracterizada por múltiplas pústulas e é considerada um marcador de doença inflamatória intestinal. Objetivo: Assim, o presente estudo tem como objetivo relatar o caso de um paciente com Doença Inflamatória Intestinal (DII) que cursou com piodermatite-pioestomatite vegetante. Materiais, sujeitos e métodos: Foi realizada uma revisão da literatura, sendo utilizadas as bases de dados: BVS e PUBMED. Resultados e discussão: Paciente com história de Doença Inflamatória Intestinal há 4 anos, cursou com início insidioso de lesões pustulosas e vesiculosas, pruriginosas, dolorosas, em mucosa labial e nasal, evoluindo com placas vegetantes recobertas por pápulas e vesículas, com base eritematosa. Ao estudo histopatológico foi identificada ulceração e hiperplasia epitelial adjacente, com infiltrado inflamatório misto predominantemente eosinofílico, com distribuição perianexial e intersticial, ocorrendo remissão das lesões após uso de 40 miligramas de prednisona. A associação da PD-PSV com DII ocorre em aproximadamente, 70% dos casos, porém ainda não se sabe a origem desta associação. Considerações finais: A porcentagem de DII associada ao envolvimento oral destaca o valor da investigação gastrointestinal, mesmo na ausência de sintomas abdominais, sendo necessária a realização de mais estudos a fim de esclarecer a origem desta associação e instituir metas terapêuticas eficazes para estes pacientes.
Nevo da Epidermólise Bolhosa: caso clínico e revisão da literatura
Authors: Oliveira Isabella Lopes de , Meira Jessica Lais Caragnato de , Silva Denny Augusta Teixeira da , Ciccozzi Maria Elisa Alcântara da Cruz , Rodovalho Bárbara
Published: August 2024

Introdução: O nevo da epidermólise bolhosa (NEB) é uma manifestação cutânea rara e distrófica associada à epidermólise bolhosa (EB), um grupo de doenças genéticas caracterizadas pela fragilidade da pele e das membranas mucosas, levando à formação de bolhas e erosões cutâneas frequentes. Objetivo: Com o resultado desta revisão, pretende-se facilitar o diagnóstico e o manejo adequado desta dermatopatia incomum de ser encontrada na prática clínica. Materiais e métodos: Foram utilizados como meios para busca dos artigos, as bases de dados eletrônicas PubMed, Scopus, Web of Science e Scholar google, Resultados e discussão: A maioria das lesões apresentou resultados falso-positivos quando as regras do ABCD e Sete-Pontos da dermatoscopia foram aplicadas.  Isso significa que o NEB representa uma exceção aos algoritmos diagnósticos da dermatoscopia, porém na avaliação dermatoscópica global é possível estimar a sua natureza benigna. Considerações finais: Enfatiza-se a importância do estudo clínico, dermatoscópico e histopatológico desses nevos para evitar erros diagnósticos e intervenções desnecessárias. Apesar do seu curso benigno, destacamos a necessidade do diagnóstico diferencial com melanoma e do monitoramento regular, desde que uma evolução maligna ainda não pode ser totalmente excluída.
Paracoccidioidomicose da genitália externa: relatório de seis novos casos e revisão da literatura
Authors: Corrêa Lianna Paula Guterres , Tassara Laura Helena Dias , Leite Ana Carolina Sudário , Oliveira Roberta Helena Marques de , Tomazzi Larissa Calderan
Published: August 2024

Introdução: A Paracoccidioidomicose (PCM) é a principal micose sistêmica no Brasil, é mais relacionada com o meio rural e peri-urbano, tem caráter insidioso e a principal porta de entrada do fungo no organismo é por via inalatória. Os órgãos comumente afetados são os pulmões (50%-100%), seguidos da pele, mucosas, linfonodos, adrenais, sistema nervoso central, fígado e ossos. Classicamente, o envolvimento do trato genital ocorre por disseminação hematogênica em pacientes com a forma crônica da doença. O diagnóstico é clínico e laboratorial. Não havendo medida de controle disponível, o tratamento precoce e correto torna-se essencial para evitar complicações e consequentemente o óbito do paciente. Objetivo: O presente estudo tem como objetivo reconhecer as manifestações clínicas e laboratoriais da PCM, principalmente sua apresentação rara na região genital, comparando-a com as literaturas específicas. Materiais e métodos: Para a formulação deste trabalho acadêmico, foram estudados artigos científicos e de revisão publicados e referenciados na Medline/PubMED, SciELO e no II Consenso Brasileiro em Paracoccidioidomicose. Resultados e discussão: Alerta-se sobre a epidemiologia da doença, maior acometimento no sexo masculino, a alta frequência de lesões cutâneas isoladas ou associadas às lesões mucosas e o diagnóstico tardio na maioria dos casos. Considerações finais: Há escassos relatos abordando essa temática, mesmo sendo uma enfermidade que está entre as dez principais causas de morte por doenças infecciosas e parasitárias, crônicas e recorrentes no país. Dessa forma, este relatório engrandecerá a literatura médica, dando ênfase ao reconhecimento precoce e tratamento correto.
Linfoma do colo do útero: relatório de dois casos e revisão da literatura
Authors: Costa Ricardo Sousa Amancio da , Silva Julia Gomes , Santos Aryanny Furtado Lucena dos , França Nathália de Almeida , Menusi Gabrielly
Published: August 2024

Introdução: O linfoma de colo uterino é uma patologia pouco frequente, sendo responsável por aproximadamente 1 a 3 em 100 casos das doenças neoplásicas ginecológicas. Ao contrário do câncer de colo uterino, nos casos de linfoma, não existe a exposição sexual como fator de risco. O sangramento vaginal anormal é o sintoma mais prevalente, seguido por dispareunia e dor pélvica. Até o momento, não foram estabelecidos protocolos sistematizados de diagnóstico e tratamento específicos para essa condição, sendo opções terapêuticas a quimioterapia, radioterapia e ressecção cirúrgica. Materiais, sujeitos e métodos: Para a elaboração deste artigo de revisão foram consultados artigos científicos e de revisão publicados e referenciados na PubMed, SciELO, Revista Brasileira de Ginecologia e Obstetrícia e Revista de Saúde Pública, entre 2008 e 2019. Resultados e discussão: O diagnóstico de linfoma de colo uterino é majoritariamente obtido pela realização de biópsia, visto que a citopatologia não possui papel relevante para o estabelecimento do diagnóstico. O tratamento baseado em quimioterapia mostrou-se eficaz para combater a evolução da doença, enquanto a ressecção cirúrgica é limitada a lesões pequenas. Considerações finais: Observa-se que o linfoma de colo uterino é uma afecção extremamente rara, com opções terapêuticas eficazes nos casos observados, porém sem consenso na literatura quanto ao custo-benefício das terapias instituídas.
Eficácia e segurança da vacinação HPV em populações específicas: uma revisão de literatura
Authors: Salles Luiza Cáceres , Almeida Beatriz Martins Guerra Pantuza , Peres Rebeca Mendes Carlos , Lucena Thallita Alves Dy , Pereira Pollyana Silva Nonato
Published: August 2024

Introdução: A infecção pelo papilomavírus humano (HPV) é uma infecção sexualmente transmissível (IST) viral de alta prevalência em todo o mundo, com grande potencial oncogênico. A vacina contra o HPV, distribuída desde 2014 pelo Sistema Único de Saúde (SUS) brasileiro, desempenha um papel profilático crucial para o câncer de colo do útero. Além disso, a vacina tem funções preventivas que não se limitam à saúde feminina. Esta revisão de literatura visa analisar a segurança e eficácia da vacinação contra o HPV em populações específicas, como indivíduos imunocomprometidos, homens, e pessoas de diferentes regiões geográficas e contextos socioeconômicos. Materiais, sujeitos e métodos: Para a elaboração desta revisão de literatura, foi realizado um levantamento bibliográfico entre os anos 2008 e 2023 nas bases de dados Medline/PubMed, Portal Regional da BVS e SciELO, utilizando seis descritores que atendem à finalidade da pesquisa. Resultados e discussão: A vacinação contra o HPV oferece proteção contra câncer do colo do útero, vaginal e vulvar, além de verrugas genitais, e também previne o câncer anal em ambos os sexos. Evidências mostram que, apesar do benefício e do acesso gratuito à vacina no Brasil, há baixa adesão, especialmente entre a população masculina. Conclusão: A vacina contra o HPV demonstrou ser altamente segura, com poucos efeitos colaterais, e eficaz na prevenção da infecção pelo vírus e suas consequências. Apesar disso, a população brasileira mostrou baixa adesão ao método, particularmente entre os homens. Portanto, apesar da vacinação ser uma estratégia eficaz na redução das complicações relacionadas ao HPV, existe resistência entre a população.
Eficácia e segurança de produtos biológicos para psoríase e artrite psoriática e seu impacto nas comorbidades: uma revisão da literatura
Authors: Schlindwein Bianca Batista , Damacena Heloísa Barros , Nascimento Manuella Martins do , Silva Mariana Maria de Freitas , Xavier Caroline
Published: August 2024

A psoríase e a artrite psoriática são doenças inflamatórias crônicas que impactam significativamente a qualidade de vida dos pacientes. Produtos biológicos têm sido utilizados como tratamento eficaz para essas condições, mas sua segurança e impacto nas comorbidades ainda são áreas de investigação ativa. Esta revisão sistemática da literatura visa avaliar a eficácia e segurança dos produtos biológicos para o tratamento da psoríase e artrite psoriática e seu impacto nas comorbidades associadas. A pesquisa foi conduzida em bases de dados eletrônicas, incluindo PubMed, Scielo e LILACS, abrangendo estudos publicados entre 2010 e 2023. Os resultados indicam que os produtos biológicos são eficazes no controle dos sintomas e na melhoria da qualidade de vida dos pacientes, com um perfil de segurança aceitável. No entanto, o impacto nas comorbidades varia, destacando a necessidade de mais estudos para uma compreensão abrangente.
Demographic diversity of participants in clinical trials conducted in Singapore
Authors: Bin Wen Jun Jerome , Chow Aloysius , Smith Helen Elizabeth , Lee Eng Sing
Published: August 2024

Introduction: The under-representativeness of participants in clinical trials limits the generalisability of results. This review evaluates the representativeness within pharmaceutical randomised controlled trials (RCTs) in Singapore.

Method: Four bibliographic databases were searched for papers on pharmaceutical RCTs which included Singapore adults (≥18 years old), published between 2017 and 2022. The demographic characteristics of study participants were compared against the population in the 2020 Singapore census. Recruitment strategies and authors’ comments on the generalisability of their findings were reviewed.

Results: Thirty-three publications were included (19 Singapore-only studies and 14 multiregional trials which included Singapore). Where data were available, we found that females and Indians were under-represented compared to the census (41.3% versus [vs] 51.1%, P<0.05; 7.3% vs 9.0%, P<0.05). Ethnic diversity varied between individual studies, and less than half (46.2%) of Singapore-only studies achieved census levels. However, more than one-third of the trials provided no data (31.6%) or partial data (5.3%) on ethnicity. Half of the multiregional publications stated the number of participants recruited from Singapore, but only 1 reported any detail beyond Asian participants. Recruitment strategies were mentioned in fewer than half (42.4%), and almost a quarter (24.2%) commented on sample representativeness or the external validity of the evidence generated.

Conclusion: There is room for improvement regarding the recruitment of RCT participants in Singapore, with particular attention to female gender and Indian ethnicity. Demographic data should also be presented in full. RCTs should be designed and reported such that clinicians can ascertain the generalisability to the Singapore population and the potential benefits from the studied interventions in clinical practice.