bluuebunny/crossref_metadata_2025 huggingface dataset:
Guesstimate of thymoquinone diversity in Nigella sativa L. genotypes and elite varieties collected from Indian states using HPTLC technique
Authors: Ravi Y. , Vethamoni Irene P. , Saxena Shailendra N. , Velmurugan S. , Santanakrishnan V. P. , Raveendran M. , Bariya Himanshu , Harsh Mistry
Published: February 2023

Thymoquinone is a valuable metabolite derived from the Nigella sativa L. seeds and has a variety of therapeutic properties. Thymoquinone was estimated using n-hexane:ethyl acetate (8:2, v/v) green solvent system and computed at a wavelength of 254 nm using the high-performance thin-layer chromatography densitometry method in distinct varieties and genotypes congregated from different geographical regions. Genotype Ajmer Nigella-13 has the paramount thymoquinone content (247.60 µg/100 mg seed) followed by Ajmer Nigella 19 (244.5 µg/100 mg seed), while the lowest amount of thymoquinone was recorded in the genotype Ajmer Nigella-6 (42.88 µg/100 mg seed). The hierarchical cluster analysis found that the collected genotypes and elite varieties were classified into four broad clusters, and the identified chemotypes with elevated thymoquinone proportion were positioned in cluster D. Significant genotypic variation in thymoquinone content is available, that can be used in exploiting pharmaceutical applications of N. sativa L. as well as a breeding programme for specific metabolite improvement perspective.
High glucose and high lipid induced mitochondrial dysfunction in JEG-3 cells through oxidative stress
Authors: Duan Yang , Sun Fuqiang , Li Yueqin , Yang Suyan
Published: February 2023

Few studies focused on the roles of high glucose combined with high lipid in placental development or fetal growth. This study was designed to investigate the roles of high glucose combined with high lipid in mitochondrial dysfunction of JEG-3 cells. We determined the cellular proliferation and apoptosis, superoxide dismutase (SOD) activity, concentration of malondialdehyde (MDA), and lactic acid dehydrogenase in control group, high glucose group, high lipid group, and high glucose and high lipid group, together with the mitochondrial dysfunction, Nrf2, HO-1, SMAC, and cytochrome C (Cyt-C) expression. Significant decrease of SOD and significant elevation of MDA was seen in high glucose and high lipid group compared with the other three groups. There was significant decrease in mitochondrial SMAC and Cyt-C in high glucose group, high lipid group, and high glucose and high lipid group compared with those of control group. Nrf2 and HO-1 protein expression in high glucose combined with high lipid group showed significant decrease compared with that of high lipid group or high glucose group. We speculated that combination of high glucose and high lipid induced oxidative stress in JEG-3 cells, and Nrf2/ARE pathway may be related to this process.
The Impact of COVID-19 on Bank Profitability: Cross-Country Evidence
Authors: Augeraud-Véron Emmanuelle , Boungou Whelsy
Published: February 2023

Using data from 5474 banks located in 23 OECD countries over the period 2019Q2–2022Q1, we study the influence of COVID-19 on bank profitability (before and during the COVID-19 vaccination period). Our results show a negative impact of the COVID-19 pandemic on bank profitability, especially at the onset of the health crisis. In addition, we find that vaccination against COVID-19 had a positive effect on bank profitability, not yet sufficient to compensate for the losses generated at the beginning of the pandemic. Finally, we show that these effects depend on the characteristics of banks (notably size and capital) before vaccination and on the severity of the crisis across countries. Overall, we provide the first evidence of the influence of vaccination on bank behavior in terms of profitability.
Technology and analysis of 08Cr9W3Co3VNbCuBN steel large diameter thick wall pipe welding process
Authors: Wang Feng , Zhang Fengshou , Ma Jiang , Ma Xizhen
Published: February 2023

In this article, the welding technology of large diameter thick wall 08Cr9W3Co3VNbCuBN (G115) heat-resistant steel pipes for the main steam pipe of a 650°C ultra-supercritical power station boiler has been investigated, and the mechanical properties and microstructure of welded joints at different wall thickness positions have also been analyzed. The results show that the mechanical properties of narrow gap welded joint of 115 mm thick large diameter 08Cr9W3Co3VNbCuBN heat-resistant steel pipe obtained by Gas tungsten arc welding (GTAW) + shielded metal arc welding (SMAW) + automatic submerged arc welding (SAW) can meet the requirements of relevant standards after tempering at 780°C. The tensile failure of the welded joint occurs in the base metal zone far away from the weld, an obvious necking phenomenon appears at the fracture position, and the welded joint has good tensile properties. No δ ferrite phase was found in the weld and heat-affected zone (HAZ). The microstructures of each zone are tempered martensite.
Effect of inlet gas velocity on gas-solid fluidization characteristics in fluidized bed
Authors: Du Shanlin , Lv Guoqiang , Ma Wenhui , Gu Guangkai , Fu Boqiang
Published: February 2023

In this article, the Eulerian–Eulerian TFM model is used to simulate the fluidization of the synthesis process of organosilicon monomers. A new method for analyzing the gas-solid fluidization characteristics is proposed by combining the gas-solid two-phase flow evolution formula with the parameters such as particle concentration and bed voidage. On this basis, the fluidization characteristics of silicon powder particles at constant velocity and variable velocity are compared, and the fluidization characteristics of silicon powder particles with different particle sizes under five sets of variable velocity are discussed. The simulation results show that compared with constant velocity, the mean bed voidage is 0.55 when silicon particles adopt variable velocity, which can not only keep silicon particles fully fluidized but also improve the problem of poor gas-solid contact. For silicon particles with particle diameters of 300.1–515 μm, variable velocity fluidization has the advantages of uniform bed distribution and sufficient gas-solid fluidization. In the five groups of variable velocity function, when the inlet gas velocity and time are the quadratic functions of the opening upward, the fluctuation of pressure fluctuation is small, and the maximum fluctuation range of particle solid phase distribution is only 0.13, indicating that the heat and mass transfer efficiency between silicon particles is better, the gas-solid mixing is sufficient, and the gas-solid fluidization quality is better.
A Study of Academic Library through the Prism of Knowledge Use and Problem Solving Networks
Authors: Ujwary-Gil Anna
Published: February 2023

The article describes a social network approach to understanding the relationships between academic library employees: knowledge use network and problem solving network with the division into strong and weak ties. The author collected the data based on a semi-structured interview and a questionnaire on a selected population of library staff in a major academic library in Poland. Then, collected data was analyzed through the non-parametric network statistics tests (quadratic assignment procedure [QAP] and multiple regression quadratic assignment procedure [MRQAP]) to test dependencies occurring in social networks of librarians. The results show a relationship between knowledge use and problem solving based on strong and weak ties between librarians, with the beta for weak ties higher than for strong ties. The network methodology is becoming a critical research approach used to understand the informal structures and complexity of the academic library. Thus, it is a valuable tool in the hands of library directors.
It’s the emotion, stupid! Emotional responses to televised debates and their impact on voting intention
Authors: Waldvogel Thomas , König Pascal , Wagschal Uwe , Becker Bernd , Weishaupt Samuel
Published: February 2023

How do emotional responses to televised debates impact on voting intention? The present article addresses this question drawing on an original dataset combining survey data and real-time responses gathered in the run-up of the 2017 German federal election. The paper contributes to three major discussions in the literature of political science and psychology. First, we show that emotional responses to media stimuli are independent explanatory factors influencing post-debate voting intention while in part mediating real-time evaluations of candidate statements. Second, our analysis demonstrates that the impact of emotional responses to televised debates can barely be deemed to be structured along one single dimension of valence but that discrete emotions show distinct effects. Third, the paper supports the notion that anger and enthusiasm have an indirect impact on voting intention by increasing the weight of political predisposition and reducing the weight of evaluation of current information on candidates’ issue stances in televised debates. We also find empirical evidence for the indirect effect of anxiety as well; it reverses the pattern and reduces the weight of political conviction while increasing the importance of evaluations about candidate statements. However, the latter finding does not seem to be very robust as in fact, substitutions are also able to generate this pattern. Finally, the paper reviews implications of the findings and discusses limitations and future perspectives of research.
Improving the nutritional quality and bio-ingredients of stored white mushrooms using gamma irradiation and essential oils fumigation
Authors: Aly Amina A. , Mohammed Marwa K. , Maraei Rabab W. , Abdalla Ahmed E. , Abouel-Yazeed Ayman M.
Published: February 2023

Mushrooms are highly perishable in nature and deteriorate within a few days after harvesting due to their high respiration rate and delicate epidermal structure. Consequently, the shelf-life of freshly harvested mushroom is limited to 1–3 days at ambient condition. Hence, the current investigation was carried out to study γ-irradiation effects (1.5 and 2.0 kGy) and essential oils (EOs) fumigation including geranium (60 and 80 μL/L) and lemongrass (40 and 60 μL/L) on nutritional quality (Vitamins C and D2) as well as bio-ingredients such as total soluble proteins, phenolic and flavonoids contents, antioxidant activity were determined as an origin of potential natural antioxidant plus the profile of phenols and flavonoids identified by HPLC. As well as activities of some enzymes (PPO, SOD, PAL, and APX) of Agaricus bisporus mushroom at 4 °C during storage time for twelve days. The findings showed that there was a reduction in the contents of Vit. C and vitamin D2 in all mushroom samples during storage, where the essential oil treatment especially 60 μL/L of geranium and 40 μL/L of lemongrass gave the least decrease (3.42 and 3.28 mg/100 g FW, respectively) of ascorbic acid content compared to the other treatments while the irradiated samples (1.5, and 2.0 kGy) gave the lowest decrease of vitamin D2 (106.30 and 114.40 mg/kg DW, respectively) at the end of storage time. The content of the bio-ingredients content was affected by the storage periods, and the samples treated with oil fumigation gave the best content and the same trend happened with the antioxidant activity. The enzymes activity increased by the storage period, especially after 4 days of storage, and then the activity decreased after that. Quantification of phenolic and flavonoid compounds affected by storage periods in all treatments and the EO-treated mushrooms gave the best amount of them. Thus, samples of mushrooms treated with oil fumigation especially 60 μL/L of geranium and 40 μL/L of lemongrass can successfully increase the nutritional value plus maintain the value of the mushrooms during storage time.
Effect of chemical additives on oil shale natural floatability
Authors: El-Midany Ayman A. , Khairy Nesreen , El-Mofty Salah E.
Published: February 2023

Improving the organic content in oil shale before retorting is a substantial target. The flotation process is proven as a good separation process for hydrophobic particles from their associated impurities. In this study, the natural floatability and the flotation with different types of reagents were investigated to show how effective these reagents are in improving their organic content (kerogen). Frothers such as pine oil and kerosene and collectors such as oleic oil and amine acetate were tested. The results indicated that the addition of any used reagent negatively affects the oil shale floatability. The descending order of flotation using chemical reagents, in terms of combustible grade and recovery, is natural floatability, with frothers, then with collectors. The grade and recovery of the naturally floated fraction are 18% and 92.7%, respectively, from 8.75% in the feed sample. The low dosage from either oleic acid or pine oil effectively reduced the grade and recovery to about 15% and 86%, respectively. Chemical reagents stand as barriers to particle–bubble attachment. The presence of higher dosages of frother leads to the agglomeration of the smaller organic particles, which leads to lower grades and recovery. While collectors play a significant role in increasing the flotation of inorganic particles rather than the organics.
Paracetamol and amoxicillin adsorptive removal from aqueous solution using phosphoric acid activated-carbon
Authors: Iqbal Munawar , Shahid Muhammad , Ali Zahid , Nazir Arif , Alqahtani Fatimah Othman , Zaheer Muhammad , Alshawwa Samar Z. , Iqbal Dure Najaf , Younas Umer , Bukhari Attaullah
Published: February 2023

Charcoal-based materials have attracted much attention for the removal of pharmaceutical agents. The charcoal-based carbon materials have green synthetic routes, high surface area, numerous active site with active functional groups available for physico-chemical interactions with adsorbate for surface-adsorptive removal of toxins. In this study, acid treated activated carbon was developed from the peach seeds using thermal pyrolysis approach. Phosphoric acid activated carbon (PAC) was further modified by HNO3 and employed as an adsorbent for the removal of amoxicillin and paracetamol and process variables were optimized for enhanced removal of amoxicillin and paracetamol. The adsorption of pharmaceutical agents was significantly affected by temperature, pH and reaction time. The amoxicillin and paracetamol sorption process onto PCA followed a pseudo second order kinetics and Langmuir isotherm model with a maximum removal capacity of 51.8 mg/g and 51.1 mg/g, respectively. The results revealed that acid activated carbon has promising efficiency for the removal of amoxicillin and paracetamol from aqueous medium and peach seeds derived PCA could be employed for the removal of these pharmaceutical agents from effluents and PAC is also extendable for the removal of other drugs from pharmaceutical wastewater streams.
Üzleti és PR etika. Az üzleti, a kommunikációs szakmai és a PR etika aktuális kérdései
Authors: Buday-Sánhta Andrea
Published: February 2023

Business and PR EthicsAndrea Buday-Sántha
Economic, political, environmental and technological transformations, that take place both domestically and globally as well as focus on the role of the cultural value crises and value changes, institutions and norms of ethics. It intends to point out the tendencies in the field of ethics, business and PR ethics, their causes and to their current phenomena, it clarifies the basic ethical values, the process of institutionalizing ethics, the practical phenomena and the challenge of ethics. It is a tendency of contradiction that the development ofethical institutions is fuelled  by the devaluation of human and ethical values and new phenomena of our changing world. With the introduction of ethical institutions for professions, markets and organizations, - in this way, by demonstrating and publishing core values and applying innovative, evolving insurance solutions -, they protect existing ethical values, also curb the effects of negative trends, and thirdly, weakening individual, organizational, market and social morality.
A Most az Apokalipszis?
Authors: Boros János
Published: February 2023

The Now is the Apokalypse?János Boros
The Now is the Apokalypse? is the title of the short paper. Following Malte Henk’s article in Die Zeit, I present and analyze his optimistic thesis that Apocalypse is finally a good thing for humankind since it inducated anattitude in Western culture, which lead to the development of humanities, of science and technology.
A Covid19 a természet reneszánsza
Authors: Bendes Ákos
Published: February 2023

Covid19 is a renaissance of natureÁkos BendesThe newly emerged pandemy sheds light on many issues ranging from fragility of our supply chains to economic depression, and all of them have ethical dimensions. To be more precise, we need to clarify the exact nature of a just conduct in the situations arising from crisis. However, the appealing consequentialist theories usually fall short of meeting a fundamental principle, namely the criterion of equal treatment. In the twentieth century, the hegemony of utilitarism started to decline because of the appearance of more sophisticated views. These theories are trying to reconcile the idea of equal moral worth withutilitarist considerations.
Rapid and Chronic Ethanol Tolerance Are Composed of Distinct Memory-Like States inDrosophila
Authors: Larnerd Caleb , Adhikari Pratik , Valdez Ashley , Del Toro Alexander , Wolf Fred W.
Published: February 2023

Ethanol tolerance is the first type of behavioral plasticity and neural plasticity that is induced by ethanol intake, and yet its molecular and circuit bases remain largely unexplored. Here, we characterize the following three distinct forms of ethanol tolerance in maleDrosophila: rapid, chronic, and repeated. Rapid tolerance is composed of two short-lived memory-like states, one that is labile and one that is consolidated. Chronic tolerance, induced by continuous exposure, lasts for 2 d, induces ethanol preference, and hinders the development of rapid tolerance through the activity of histone deacetylases (HDACs). Unlike rapid tolerance, chronic tolerance is independent of the immediate early geneHr38/Nr4a. Chronic tolerance is suppressed by the sirtuin HDACSirt1, whereas rapid tolerance is enhanced bySirt1. Moreover, rapid and chronic tolerance map to anatomically distinct regions of the mushroom body learning and memory centers. Chronic tolerance, like long-term memory, is dependent on new protein synthesis and it induces thekayak/c-fosimmediate early gene, but it depends on CREB signaling outside the mushroom bodies, and it does not require the Radish GTPase. Thus, chronic ethanol exposure creates an ethanol-specific memory-like state that is molecularly and anatomically different from other forms of ethanol tolerance.

SIGNIFICANCE STATEMENTThe pattern and concentration of initial ethanol exposure causes operationally distinct types of ethanol tolerance to form. We identify separate molecular and neural circuit mechanisms for two forms of ethanol tolerance, rapid and chronic. We also discover that chronic tolerance forms an ethanol-specific long-term memory-like state that localizes to learning and memory circuits, but it is different from appetitive and aversive long-term memories. By contrast, rapid tolerance is composed of labile and consolidated short-term memory-like states. The multiple forms of ethanol memory-like states are genetically tractable for understanding how initial forms of ethanol-induced neural plasticity form a substrate for the longer-term brain changes associated with alcohol use disorder.
Czy twórczość Jana Kochanowskiego może być źródłem poznania prawa?
Authors:   Akademia Ekonomiczno-Humanistyczna w Warszawie, Makiłła Dariusz
Published: February 2023

The cognitive function of literary works is usually directly related to the social, historical or cultural context, reflecting, by means of literary fiction, the knowledge of what actually happened, or what could happen, being an expression of the projection of reality in the literary work. In this sense, it is possible for the creator of a literary work to relate to the actual reality in which he operated, legal and systemic relations, if their presentation in the presented work is important for the literary fiction that creates the work. Therefore, if we assume that a literary projection, even a fictional one, presents a sequence of events, and at the same time is embedded in a specific context, appropriate for the time of the work’s creation, in this case also covering legal and systemic relations relevant to the epoch, a literary work may thus fulfill a cognitive function. in the field of learning about the history of law or the political system. Based on these assumptions, the tragedy of Jan Kochanowski, The Greek Envoys, presented in 1578 in the presence of the royal couple during the wedding ceremonies of the then Crown Deputy Chancellor, Jan Zamoyski with Krystyna Radziwiłł, was examined. The current view that the work of J. Kochanowski reflected in the sphere of its literary fiction the course of the sessions of the former Polish Sejm from the second half of the 16th century, which its creator used to present political and ideological issues of that era, was verified in relation to the concept of the sources of learning about law. The result of examining the literary work of J. Kochanowski, especially those parts in which it was possible to demonstrate the Author’s reference to legal and systemic issues, is the recognition that the manner of their presentation can be treated as a special, historical source of learning about law, in which an important role, as an instrument for learning about it, it plays the historical as well as the political context, which is the basis of literary fiction.
Ius caducum w Lublinie w pierwszej ćwierci XVII w.
Authors:   Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Seroka Krzysztof
Published: February 2023

The research objective of the study focuses on the functioning of the escheat law within cities. The research, although undertaken in a limited chronological scope, may contribute to the introduction of an issue that has not yet been recognized. The subject of the findings are the detailed issues of the functioning of the escheat law in former Poland, in particular the implementation of the monarch’s prerogative in the light of its limitations imposed in the parliamentary constitutions, the property scope of the escheat law and the issue of the participation of local royal state authorities, i.e. the starost’s office and local (municipal) government authorities, in the execution of the monarch’s decisions. Apart from persons appointed to the inheritance by virtue of law or will, the monarch could also participate in the inheritance proceedings. A heirless or testamentless inheritance fell to the king who, under the law of the escheat (ius caducum), embraced such an inheritance, which was then known in Poland as the “puścizna”. The ruler’s powers in the field of ius caducum were limited by the parliamentary constitutions requiring the king to grant noble goods acquired under the escheat law only to distinguished persons from among the nobility. These restrictions did not apply to the king’s administration and disposal of the bourgeois escheat goods. The process of granting by the king the caduceus estates of the burghers to the nobility are presented on the basis of royal documents concerning the inheritance of Lublin residents passing down to the nobility in the first quarter of the 17th century. The sources used in the research are eighteen documents found in the books of the Crown Record kept by the royal chancellery. The applied research method relates to research on the sources of law. A feature of the presented findings is reliance on unpublished archival sources, which require taking into account the philological and palaeographic methods related to the preparation of sources for analysis.
O potrzebie studiów nad historią prawa – przemyślenia na tle rozważań Tomasza Opalińskiego zawartych w monografii Stan chłopski w Księstwie Warszawskim w świetle akt sądowych
Authors:   Akademia Pomorska w Słupsku, Kanecki Oskar
Published: February 2023

Studies on the history of political systems and law involve a necessity to present historic law institutions with a modern view. This requires from the researcher a good command of legal language and scientific terminology. This article is an attempt to analyze the characteristics of studies dealing with the history of law against the background of Tomasz Opaliński’s thoughts included in the monograph “State of peasantry in the Duchy of Warsaw in the light of court records”. The Author described the situation of peasants in the years 1808–1815 in the light of the judicial documents of courts of peace. This issue is important because the Constitution of the Duchy of Warsaw, abolishing „slavery”, introduced the equality of all citizens in terms of the law, which enabled the establishment of common courts. The historical and legal method was applied in this research. The book consists of four chapters, numerous appendices and its contents were organized according to subject-chronology. The Author discussed general issues (including the organization of the judiciary in the Crown of the Kingdom of Poland and in the Duchy of Warsaw), court records, major social and economic problems of peasants, as well as interstate relations (between peasants, peasants and nobles, peasants and burghers, peasants and Jews, peasants and clergy).
Knockout of murine Lyplal1 confers sex-specific protection against diet-induced obesity
Authors: Vohnoutka Rishel B , Kuppa Annapurna , Hegde Yash , Chen Yue , Pant Asmita , Tohme Maurice E , Choi Eun-Young (Karen) , McCarty Sean M , Bagchi Devika P , Du Xiaomeng , Chen Yanhua , Chen Vincent L , Mori Hiroyuki , Bielak Lawrence F , Maguire Lillias H , Handelman Samuel K , Sexton Jonathan Z , Saunders Thomas L , Halligan Brian D , Speliotes Elizabeth K
Published: February 2023

Human genome-wide association studies found single-nucleotide polymorphisms (SNPs) near LYPLAL1 (Lysophospholipase-like protein 1) that have sex-specific effects on fat distribution and metabolic traits. To determine whether altering LYPLAL1 affects obesity and metabolic disease, we created and characterized a mouse knockout (KO) of Lyplal1. We fed the experimental group of mice a high-fat, high-sucrose (HFHS) diet for 23 weeks, and the controls were fed regular chow diet. Here, we show that CRISPR-Cas9 whole-body Lyplal1 KO mice fed an HFHS diet showed sex-specific differences in weight gain and fat accumulation as compared to chow diet. Female, not male, KO mice weighed less than WT mice, had reduced body fat percentage, had white fat mass, and had adipocyte diameter not accounted for by changes in the metabolic rate. Female, but not male, KO mice had increased serum triglycerides, decreased aspartate, and decreased alanine aminotransferase. Lyplal1 KO mice of both sexes have reduced liver triglycerides and steatosis. These diet-specific effects resemble the effects of SNPs near LYPLAL1 in humans, suggesting that LYPLAL1 has an evolutionary conserved sex-specific effect on adiposity. This murine model can be used to study this novel gene-by-sex-by-diet interaction to elucidate the metabolic effects of LYPLAL1 on human obesity.
Integrierte und automatisierte Cashflow-Planung im Treasury
Authors:   Mietzner
Published: February 2023

Nicht mehr nur Zahlen für die Liquiditätsplanung zusammenstellen und manuell eintragen, sondern aus der Budgetplanung abgeleitete, in sich konsistente Cashflows als automatisiert erzeugte Vorschlagswerte konsumieren? Dieser Artikel beleuchtet den Hintergrund, die verschiedenen Herausforderungen auf dem Weg dorthin und gibt einen Einblick, wie bspw. aus Umsatzerlösen Kundeneinzahlungen modelliert werden können – Erfahrungen und Gedanken bei ZEISS.
Robotic Process Automation
Authors:   Nikiforow,   Wagener
Published: February 2023

Die Herausforderungen in der Finanzabteilung werden immer vielseitiger. Um den steigenden Anforderungen an Menschen und Daten auch in Zukunft gerecht werden zu können, bedarf es Unterstützung, wie sie etwa Robotic Process Automation bietet. Die Software-Roboter für den Einsatz im Büro steigern nicht nur die Effizienz, sondern helfen Unternehmen auch dabei, mit dem Wandel Schritt zu halten. Der Beitrag stellt die Grundlagen und Anwendungsmöglichkeiten von Robotic Process Automation vor.
Künstliche Intelligenz im Finanzcontrolling
Authors:   Derfuß,   Wiesche
Published: February 2023

Ist Künstliche Intelligenz (KI) die Zukunft des Finanzcontrollings? Diese Frage bewegt derzeit Controllingforschung und -praxis. Dieser Artikel konkretisiert die Möglichkeiten und -grenzen der Nutzung von KI-Systemen im Finanzcontrolling. Häufig werden KI-Systeme menschliche Tätigkeiten ergänzen, mit entsprechenden Konsequenzen für die Gestaltung dieser Zusammenarbeit.
Herausforderungen des CFOs für die -Digitalisierung des Controllings
Authors:   Epstein,   Brockmann
Published: February 2023

In einer Ära der digitalen Disruption stellen sich alle Funktionen eines Unternehmens neu auf. Das gilt auch für das Controlling. Finanzexperten erwerben neue Fähigkeiten und nehmen eine aktive Rolle als Business Partner ein: Sie werden zu Co-Piloten des Managements mit strategischem Horizont. Mit innovativen Ansätzen erzielt die Funktion eine höhere Produktivität in ihren etablierten Aufgaben ebenso wie in den vielfältigen neuen Einsatzbereichen. In dem Beitrag wird beschrieben, wie CFOs durch die Transformation des Controllings für die digitale Zukunft attraktive Chancen heben können.
Рецепция агиографической традиции в рассказе А. Варламова «Звездочка»
Authors: Харитонова Анна
Published: February 2023

Статья посвящена изучению агиографической традиции в рассказе А. Варламова «Звездочка». Установлена генетическая связь образа главной героини Лизы Непомилуевой с житийными образами на ценностном и структурном уровнях. Рассказ также связан с текстом поэмы Э. Багрицкого «Смерть пионерки», где в центре стоит противоположный мотив: отказ маленькой девочки надеть на смертном одре крест. Рассказ А. Варламова можно рассматривать как аксиологическую антитезу тексту Э. Багрицкого и, шире, идее нового, революционного типа героя, активно утверждаемого в советской литературе 1930-х гг. В рассматриваемом рассказе представлен иной тип литературного идеала, основанный на евангельских ценностях. Центральный образ первоклассницы Лизы Непомилуевой имеет характерные черты, присущие агиографическому герою, а художественное пространство рассказа, связанное с образом Лизы, включает в себя идею сакрального. Рисунок образа героини определяется доминантой кардиогнозиса, или, иначе, постижения мира сердцем. Категория кардиогнозиса не только помещает образ Лизы в пространство заповедей блаженства, но и является сюжетообразующей, определяющей всю архитектонику произведения. Авторское обращение к агиографии выявлено и в особом мотивном комплексе: мотивах страдания, креста и крестоношения, кроткого несения поругания, которые могут быть рассмотрены как аллюзия к мученическому житию. Таким образом, рецепция агиографической традиции в тексте А. Варламова позволяет говорить об идеальности образа главной героини, возводящей его к идее святости, и о принадлежности произведения национальной духовной традиции.
Veterinary pharmaceuticals in aquaculture wastewater as emerging contaminant substances in aquatic environment and potential treatment methods
Authors: Senarathna DDTT Darshana , Abeysooriya KHD Namal , Vithushana T , Dissanayake DMNA
Published: February 2023

Veterinary pharmaceuticals are still unregulated and their residues in the environment have the potential to cause considerable impact on ecosystems. Water pollution due to veterinary pharmaceuticals gained worldwide attention because they deteriorate the water quality and impart a toxic effect on living organisms. Therefore, the effective aquaculture wastewater treatment for veterinary pharmaceuticals removal before releasing into the environment is necessary to prevent the risk of environmental contamination and subsequent negative health and economic impacts on both the human and aquaculture industry. This review provides an overview of currently available methods to remove veterinary pharmaceuticals available in aquaculture wastewater while reviewing some methods already studied for other types of pharmaceuticals but possible to use in aquaculture in the future and the scope of the review has been limited to aquaculture antibiotics used as veterinary medicines. Several water refinement techniques such as conventional mechanical, chemical, biological and physical wastewater treatment methods are practiced but they are not with suitable efficiency. Several studies were published covering small or special sections of water pollution by pharmaceuticals. But most of these studies have been done targeting to remove the antibiotics coming from hospital effluent, livestock or animal farm, and veterinary practices. There are very few research studies done specifically for aquaculture wastewater treatment against veterinary pharmaceuticals. Therefore, more attention and efforts must be given to this topic to be developed and to know all details concerning the toxicity of veterinary pharmaceuticals and how they can be removed from the aquaculture wastewaters.
Evaluation of shallow groundwater in Rural Kebbi State, NW Nigeria, using multivariate analysis: implication for groundwater quality management
Authors: Wali Saadu Umar , Gada Murtala Abubakar , Hamisu Isah , Umar Kabiru Jega , Abor Isa Garba
Published: February 2023

This study assessed shallow groundwater in rural Kebbi State using Pearson’s Correlation (r), Factor Analysis (FA), and Hierarchical Cluster Analysis (HCA). One hundred (100) shallow groundwater samples were drawn randomly from hand-dug shallow wells in 10 Local Government Areas (LGAs). Physical parameters (pH, temperature, TDS, EC, salinity) were analysed in situ using hand-held metres. Separate water samples were taken to analyse ions (Fe, Zn, K, Mg, Mg, HCO3, Ca). Results revealed that shallow groundwater is lightly acidic, except in Zuru and Fakai LGAs, where an alkaline condition occurred. Correlation analysis revealed that the dissolved solids in shallow aquifers result from natural geological and anthropogenic influences. However, FA had shown that most of the variability in shallow groundwater is influenced by natural geological factors with little evidence from anthropogenic inputs. The HCA categorised shallow groundwater into three groups: those shallow wells having higher concentrations of Zn and Cl with more elevated salinity and temperature; those shallow wells having very low salinity in central Kebbi State, and those shallow aquifers having alkaline waters. Except for higher Fe and Zn concentrations, the shallow aquifers contained water of excellent quality for drinking. Correlation analysis, FA, and HCA present simple statistical tools for assessing the hydrochemistry of groundwater.
Literacidad crítica en contextos interculturales: el caso de la Escuela Primaria Bilingüe Emiliano Zapata
Authors: Vázquez Ahumada María Andrea , Zamudio Ana Lucía , Martínez Buenabad Elizabeth
Published: February 2023

El presente trabajo describe la experiencia del proyecto Los siete ratones ciegos dan la vuelta al mundo desarrollado en la Escuela Primaria Bilingüe Emiliano Zapata del Sector 02 de Educación Indígena del estado de Puebla, México, y cómo profesores, alumnos y alumnas, madres y padres, así como colaboradoras y colaboradores de todos los rincones del mundo, se unieron para celebrar el Día Internacional de las Lenguas Maternas.

Igualmente propone una reflexión acerca de las implicaciones tanto pedagógicas como interculturales y humanas de un ejercicio colectivo. Desde la perspectiva crítica tanto de la literacidad como del análisis del discurso y de la diversidad lingüística, se da cuenta de cómo se articula lo escolar-académico, lo literario y lo personal e identitario, así como lo emotivo, en un ejercicio horizontal y transversal de construcción de saberes dentro de la educación intercultural. A través del ejercicio pedagógico descrito se logró que los estudiantes indígenas de esta escuela conformaran su identidad desde el valor de su primera lengua en el diálogo con otras lenguas y no desde la concepción de grupo vulnerable.
Continuous Wave of Condensation Improves the Filling of Curved Canals: a Micro-CT Study
Authors: Pinto Jader Camilo , Pivoto-João Mariana Mena Barreto , Guerreiro-Tanomaru Juliane Maria , Reyes-Carmona Jessie Fabiola , Tanomaru-Filho Mario
Published: February 2023

The aim of this study was to compare the filling capacity in curved root canal using a new continuous wave of condensation technique (Termo Pack II, Easy Dental Equipments, Brazil) or lateral compaction. The percentage of voids in the filling of mesial root canals of mandibular molars was assessed by micro-computed tomography (micro-CT). Mesial root canals (n=24) of mandibular molars with a degree of curvature between 20° and 40° were prepared using rotary system (ProDesign Logic, Easy, Brazil) up to #35, .05 taper. The root canals were filled by using the continuous wave of condensation system or lateral compaction and AH Plus sealer (n=12). Scanning at 9 µm was performed after preparation and after filling by using micro-CT SkyScan 1176. The volumetric percentage of filling material and voids (total length and in each root canal third) were calculated. Data were analyzed using ANOVA/Tukey and Student’s t tests (α=0.05). Before the filling techniques, the root canals volume after preparation was similar (p>0.05). The root canals filled by the continuous wave of condensation technique presented the lowest percentage of voids, and the greatest percentage of filling material in total length and thirds (cervical, middle and apical) (p<0.05). Both techniques were not able of completely filling the root canals. The continuous wave of condensation technique Termo Pack II promoted better root canal filling in curved root canals, when compared with lateral compaction.
Effect of Final Irrigation Protocols on Radicular Dentin Permeability and Push-Out bond Strength in Endodontically Treated Teeth
Authors: Benavides Marianella , Hernández Meza Erick , Reyes-Carmona Jessie
Published: February 2023

This study aimed to analyze the effect of several final irrigation protocols on tubular permeability and push-out bond strength of an epoxy resin-based cement to radicular dentin. The crowns of 110 human teeth were removed to standardize at 17mm in length. The root canals were instrumented and irrigated with 5ml of 5% NaOCl and 17% EDTA. The samples were then randomly divided into 5 groups (n=22) according to the final irrigation protocol. Subsequently, the samples were subdivided into two different groups to assess dentin permeability or the evaluation of the push-out bond strength. In Group 1, all samples displayed the formation of brown-like precipitates. Group 2 and Group 5 demonstrated cleaner dentin walls. The push-out bond test after 72 hours denoted a significant difference when comparing Group 1 vs Group 2 and Group 1 vs Group 3. After thermocycling, a significant difference is observed between Group 1 and all remaining groups. The irrigation protocol using distilled water prior to irrigation with chlorhexidine significantly reduces the formation of intracanal precipitates by avoiding interactions between irrigants. The push-out bond strength of epoxy resin-based cement is directly influenced by the precipitates formed in the root canal after irrigation and the time of thermocycling.
INCLUSIÓN DE DERECHOS IGUALITARIOS EN AGENDA PÚBLICA DURANTE SEGUNDA RONDA ELECTORAL 2018
Authors: Hütt Herrera Harold
Published: February 2023

El objetivo de la presente investigación es analizar la inclusión de los derechos igualitarios de la población LGTBIQ+ en la agenda pública, en el marco de la segunda ronda electoral de las elecciones 2018 en Costa Rica. La metodología utilizada se basó en un monitoreo de medios de comunicación durante el periodo del 4 de febrero al 1 de abril del 2018, así como la sistematización de la información con base en el modelo de coaliciones promotoras. La investigación se realizó durante el período 2018-2019, y permitió identificar el impacto mediático en la agenda política.
Adenogenesis Factors FGF7, FGF10, FGF23, IFN-τ and HGF in Endometriosis Tissue Respect to Eutopic Endometrium: An Immunohistochemical Study
Authors: Signorile Pietro G. , Baldi Alfonso , Viceconte Rosa , Vincenzi Bruno , Montella Marco
Published: February 2023

Endometriosis is a pathological condition defined by the occurrence of endometrial glandular and stromal structures in anatomical compartments different from the uterine cavity. Endometriosis is a genetic polymorphism, estrogen-dependent inflammatory disease. This very common pathological entity causes a high level of morbidity in patients; it is also considered one of the most important causes of infertility. We and others have proposed as a pathogenetic mechanism of endometriosis a modification in the fine tuning of the processes of organogenesis of the uterus. We have correlated the immunohistochemical expression in deep endometriotic lesions and in normal endometrial tissue of several molecular factors that are implicated in the embryonic development of the uterine glands. We noticed a significant higher expression both for epithelium and stroma in the controls respect to the endometriosis samples for FGF7, FGF-10 and HGF. Interestingly, regarding FGF-23 and IFN-τ, we observed a significant higher expression in the ectopic endometrial stroma compared to the eutopic endometrium, while thepithetlium expression did not display a significant differential expression in endometriosis tissues respect to normal endometrium. The data generated support the fact that endometriosis tissues, both the epithelial and stromal component, have a different phenotype respect to the eutopic endometrium and sustain the hypothesis that alterations in the molecular mechanisms in control for adenogenesis and survival of endometrial structures are linked to the genesis and survival of endometriosis lesions outside of the uterus.
Comprehensive Associations between Acidosis and the Skeleton in Patients with Kidney Disease
Authors: Levy Rebecca V. , McMahon Donald J. , Agarwal Sanchita , Dempster David , Zhou Hua , Misof Barbara M. , Guo X.E. , Kamanda-Kosseh Mafo , Aponte Maria Alejandra , Reidy Kimberly , Kumar Juhi , Fusaro Maria , Brown Denver D. , Melamed Michal L. , Nickolas Thomas L.
Published: February 2023

Significance Statement

Renal osteodystrophy (ROD) contributes substantially to morbidity in CKD, including increased fracture risk. Metabolic acidosis (MA) contributes to the development of ROD, but an up-to-date skeletal phenotype in CKD-associated acidosis has not been described. We comprehensively studied associations between acidosis and bone in patients with CKD using advanced methods to image the skeleton and analyze bone-tissue, along with biochemical testing. Cross-sectionally, acidosis was associated with higher markers of bone remodeling and female-specific impairments in cortical and trabecular bone quality. Prospectively, acidosis was associated with cortical expansion and trabecular microarchitectural deterioration. At the bone-tissue level, acidosis was associated with deficits in bone mineral content. Future work investigating acidosis correction on bone quality is warranted.

Background:

Renal osteodystrophy is a state of impaired bone quality and strength. Metabolic acidosis (MA) is associated with alterations in bone quality including remodeling, microarchitecture, and mineralization. No studies in patients with CKD have provided a comprehensive multimodal skeletal phenotype of MA. We aim to describe the structure and makeup of bone in patients with MA in the setting of CKD using biochemistry, noninvasive imaging, and histomorphometry.

Methods:

The retrospective cross-sectional analyses included 180 patients with CKD. MA was defined as bicarbonate ≤22 mEq/L. We evaluated circulating bone turnover markers and skeletal imaging with dual energy x-ray absorptiometry and high-resolution peripheral computed tomography. A subset of 54 participants had follow-up. We assessed associations between baseline and change in bicarbonate with change in bone outcomes. Histomorphometry, microCT, and quantitative backscatter electron microscopy assessed bone biopsy outcomes in 22 participants.

Results:

The mean age was 68±10 years, 54% of participants were male, and 55% were White. At baseline, acidotic subjects had higher markers of bone turnover, lower areal bone mineral density at the radius by dual energy x-ray absorptiometry, and lower cortical and trabecular volumetric bone mineral density and impaired trabecular microarchitecture. Over time, acidosis was associated with opposing cortical and trabecular effects: cortical expansion but trabecular deterioration. Bone-tissue analyses showed reduced tissue mineral density with increased heterogeneity of calcium distribution in acidotic participants.

Conclusions:

MA is associated with multiple impairments in bone quality. Future work should examine whether correction of acidosis improves bone quality and strength in patients with CKD.
Gráficos con R-Studio para estadística descriptiva en ingeniería
Authors:   Universidad Cooperativa de Colombia, Nova Martínez Manuel Arturo , Sorza Álvarez Elkin Giovani
Published: February 2023

La estadística descriptiva proporciona herramientas que tienen por objeto resumir, representar e interpretar información contenida en un conjunto de datos; entre ellas se encuentran los gráficos estadísticos. En ingeniería resulta importante desarrollar competencias para el diseño y la creación de gráficos, principalmente por la necesidad de comunicar información de manera visual, que sea comprendida fácilmente, incluso por personas que carezcan de conocimientos de estadística. Existen programas no estadísticos de uso general (por ejemplo, Excel) que integran funciones para construir algunos gráficos, a raíz de la necesidad transversal de presentar información; sin embargo, cuando se estudia estadística es más conveniente hacerlo en un entorno estadístico que tenga todas las funcionalidades propias del área. R es actualmente el software estadístico más potente, el programa más flexible y de mayor capacidad para la construcción de gráficas. En esta guía se muestra cómo construir los gráficos estadísticos básicos, propios de un curso de introducción a la estadística descriptiva, en el entorno de desarrollo integrado (IDE) R-Studio.
Coronavirus Disease-2019 Conspiracy Theories are Alive and Breathing on the Internet
Authors:   Boos Health, Saddle Brook, NJ, USA, Boos John
Published: February 2023

The more detailed origin stories of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and the coronavirus disease2019 (COVID-19) vaccines are both unknown to the layperson. These unknowns serve as opportunities for misinformation messaging to the layperson. How did pharmaceutical companies create a vaccine within a matter of months to a year for a relatively new virus? Were aborted fetal cells used to make the COVID vaccines? What if there are long-term side COVID-19 vaccine effects not yet known to scientists and the public? While the internet, without a fact-checker and combined with opportunity and individual attitudes and information preferences, may flourish with misinformation and conspiracy theories. Scientists have a professional duty to publish evidence-based data in all pursuits, but recently the scientific community has spent much time educating the public in hopes of neutralizing many of the COVID fallacies we see every day on social media.