bluuebunny/crossref_metadata_2025 huggingface dataset:
A Comprehensive Survey on Deep Graph Representation Learning Methods
Authors: Chikwendu Ijeoma Amuche , Zhang Xiaoling , Agyemang Isaac Osei , Adjei-Mensah Isaac , Chima Ukwuoma Chiagoziem , Ejiyi Chukwuebuka Joseph
Published: October 2023

There has been a lot of activity in graph representation learning in recent years. Graph representation learning aims to produce graph representation vectors to represent the structure and characteristics of huge graphs precisely. This is crucial since the effectiveness of the graph representation vectors will influence how well they perform in subsequent tasks like anomaly detection, connection prediction, and node classification. Recently, there has been an increase in the use of other deep-learning breakthroughs for data-based graph problems. Graph-based learning environments have a taxonomy of approaches, and this study reviews all their learning settings. The learning problem is theoretically and empirically explored. This study briefly introduces and summarizes the Graph Neural Architecture Search (G-NAS), outlines several Graph Neural Networks’ drawbacks, and suggests some strategies to mitigate these challenges. Lastly, the study discusses several potential future study avenues yet to be explored.
PRIMARY BREAKUP INSTABILITY OF LIQUID JET IN CROSSFLOW
Authors: Bhatia Bharat , Johny Tom , De Ashoke
Published: October 2023

The liquid jet in crossflows (LJICF) has been analyzed using the compressible volume of fluid-Lagrangian particle
tracking (VOF-LPT) coupled solver for the instabilities that result in the primary breakup. It is understood that
the dominant force driving the instabilities changes with the Weber number and momentum flux ratio. The Kelvin-
Helmholtz (KH) instability is found to be prevalent at low momentum flux ratio, whereas the Rayleigh-Taylor (RT)
instability is dominant at higher values. In the present work, the instability causing the primary breakup is analyzed for a range of Weber numbers and momentum flux ratios, where the breakup is predominantly caused by either KH or RT instability. It is observed that the transition from KH waves to RT waves happens for the momentum flux ratio values ranging from 20 to 50. Also, the lower Weber number cases show the domination of long KH waves on the liquid jet column with negligible turbulence.
Interpretación de planos ingenieriles basados en los requisitos del Reglamento Colombiano de Construcción Sismorresistente NSR-10
Authors:   Universidad Cooperativa de Colombia, Forero Mayorga Eder , Moreno Sierra Vivian Carolina
Published: October 2023

La presente guía de interpretación de planos de ingeniería tiene como objetivo proporcionar tanto a docentes como a los estudiantes del programa de Ingeniería Civil un apoyo que les permita conocer todos los requisitos indispensables para comprender y analizar los planos ingenieriles, en planta, corte y alzado, basados en los requisitos del Reglamento Colombiano de Construcción Sismo resistente NSR-10. Además, la guía es una herramienta fundamental y precisa en la interpretación de los planos de ingeniería, puesto que es esencial garantizar la correcta implementación de un proyecto. Un entendimiento completo de los diferentes símbolos, códigos y dimensiones presentes en los planos permite una adecuada ejecución de las tareas y a prevención de errores costosos. También se menciona que la interpretación de planos de ingeniería son documentos fundamentales en proyectos de construcción y diseño. Proporcionan información detallada y precisa sobre dimensiones, especificaciones técnicas y mantenimiento de los diferentes elementos. En definitiva, esta guía aborda los siguientes puntos clave: una introducción a los temas centrales con los planos de ingeniería; se ofrece una visión general de los diversos tipos de planos como los arquitectónicos y los técnicos, que incluyen planos estructurales, eléctricos e hidrosanitarios. Cada uno se presenta con sus respectivos símbolos y convenciones para una mejor interpretación.
Position of F&B Service and Customers’ Perception of F&B Service Quality and Revisit Intention in Casino Operations
Authors:   The Tourism Sciences Society Of Korea, Kim Jung-A , Chong Yu-Kyeong
Published: October 2023

The purpose of this study was to examine the perception of F&B service quality at a foreigners-only casino, which is known as a high value-added industry, and to study how F&B service quality at the casino affects customer satisfaction and revisit intention. In the research results, casino F&B service was recognized as a very important component that was divided into a total of four factors: food service, customized service, service environment, and image of employees. The three factors affecting customer satisfaction were food service, service environment, and image of employees. Only the food service and customized service factors significantly affected the retention of customers. Also, customer satisfaction of casino F&B services was found to have a positive (+) impact on revisit intention. As shown in the research results, the factors that customers perceived to be the most important relating to F&B service quality had a significant effect on customer satisfaction and revisit intention. Therefore, based on such results, it can be concluded that F&B service quality improvement plans proposed in this study can provide casinos with new F&B marketing information to maximize sales by improving satisfaction levels and increasing revisit intention.
Take it Personally: What May it Take to Become Designers for Pluriversality?
Authors: Torretta Nicholas B.
Published: October 2023

This paper argues that if we aim to Design for pluriversality, we cannot do so from a universalist notion of what it means to be a Designer. This paper briefly describes the efforts of decolonizing Design, then looks into two Design approaches in socially engaged Design methods that frame how Designers connect to place and people: Situated Design and Design Empathy. These discourses are then further nuanced by adding a decolonial lens, nuancing how Designers are situated and engage through the colonial matrix of power. This then serves as a map of aspects to be taken into consideration for nuancing a Designer’s relation place, history, profession and people in the colonial matrix of power. This paper then suggest the notions of awarenessing, an action-oriented reflective awareness on one’s position, flexibility in Design processes and the incorporation of personal aspects into Designing as possible ways to open up for pluriversal Design stances. The paper concludes by outlining potential implications of opening up for such stances in doing, writing and teaching Design.
Los talleres artesanales y sus prácticas: una agenda de investigación para las transiciones
Authors: Bastidas Pérez Adriana
Published: October 2023

El texto propone que procesos de investigación desde la perspectiva de ‘diseños otros’ contribuyen a resituar los talleres artesanales y sus prácticas como espacios con capacidad de enactuar el mundo y con la posibilidad de transicionar a procesos productivos y comerciales más humanos y sostenibles. Para exponer esta idea, el artículo realiza un análisis del concepto de taller artesanal desde diferentes miradas y delimita una para el proyecto desde el concepto de transiciones. Posteriormente, se contextualiza la situación histórica y presente de los talleres artesanales en Nariño (Colombia), región con una amplia y reconocida tradición artesanal. La información se soporta en informes estatales, autores reconocidos y datos recopilados por medio de trabajo etnográfico y herramientas de diseño en trabajo participativo (2021-2023).Como resultado se propone una agenda de trabajo para las transiciones en la que se aborda el taller como eje central de estudio—un espacio en el que además de procesos productivos y comerciales se dan prácticas creativas y cooperativas que tienen origen en el saber hacer—. Este conocimiento, conformado por procesos de carácter intelectual, social, ambiental y cooperativo esenciales para la pervivencia de los oficios, incluye además prácticas que pueden cambiar la relación entre talleres, instituciones y el diseño, al potenciar elementos positivos del taller en beneficio de prácticas cotidianas y comunitarias.
Diseño de lo incomún: límites epistemológicos del codiseño entre diseñadores industriales y artesanos
Authors: Montes Cruz José Joaquín , Piracoca Chaves Diego , Andrés Pérez Guillermo , Pardo Gibson Jaime
Published: October 2023

El presente trabajo relata y compila experiencias obtenidas en cuatro visitas de campo a una región de Colombia, en las que se llevaron a cabo varios talleres de codiseño entre tejedoras-artesanas de la etnia wayúu con diseñadores industriales. Este caso de estudio permite cuestionar los escenarios de trabajo entre los artesanos y diseñadores desde el concepto de autonomía. Además, indica algunos cambios que los implicados en el codiseño necesitan para lograr la participación con mayor justicia social además de la modificación de los roles. Al considerar la antropología simétrica y el concepto de incomunes como herramientas desarrolladas en ciencias sociales, emprendemos una reflexión sobre las diferencias entre los participantes de los talleres como diferencias entre mundos conectados y no como epistemologías separadas.Lo que nos diferencia son nuestros recorridos, pero todos habitamos un mundo donde deben caber más mundos, un pluriverso. Este compromiso ético invita a pensar el diseño industrial como un tipo de artesanía y la artesanía como un tipo de diseño, abriendo las puertas para investigaciones posteriores. Bajo esta mirada, la innovación se entiende como lo que propicia cambios sociales y no sólo lo que logra cambiar exitosamente un mercado, así que todos los participantes de los intercambios deben modificar sus prácticas para lograrlo. Defendemos que la enorme diferencia de estatus entre los participantes del taller es la que permite que esta experiencia aclare problemas de participación relacionada con prácticas materiales y experimentales como el diseño industrial y la artesanía en muchos otros lugares del mundo.
Seçilmiş Ekonomik Değişkenlerin Ekolojik Ayak İzine Etkisinin Analizi: BRICS-T Ülkeleri Örneği
Authors: DUMAN Erhan
Published: October 2023

Küreselleşme, hızlı kentleşme, aşırı tüketim, iklim değişikliği ve artan sanayileşme faaliyetleri insanlığın çevre üzerindeki talep baskısının artmasına neden olmuştur. Bu çalışmada BRICS-T ülkelerinde 1992-2018 dönemine ait kişi başına düşen gelir, dışa açıklık, doğrudan yabancı yatırım, yenilenebilir enerji tüketimi ve toplam ar-ge harcamalarının ekolojik ayak izine etkisi FMOLS ve DOLS yöntemleriyle araştırılmıştır. İnceleme sonucunda, BRICS-T ülkelerinde kişi başına düşen gelir, dışa açıklık ve doğrudan yabancı yarımlardaki %1 puanlık artış sırasıyla ekolojik ayak izini %0,21, %0,29 ve 0,39 oranında artırmaktadır. Yenilebilir enerji tüketimi ve ar-ge harcamalarındaki %1 puanlık artış ise ekolojik ayak izini %0,71 ve %0,55 oranında azaltmaktadır.
Öğrenmeye Yönelik Ebeveyn Desteğinin Öğrencilerin Çevrim içi Öğrenme Hazırbulunuşluğundaki Rolü
Authors: DÜZENLİ Ömer , KARA Mehmet
Published: October 2023

Bu araştırmanın amacı öğrencilerin çevrim içi öğrenme hazırbulunuşluğunda öğrenmeye yönelik ebeveyn desteğinin rolünün incelenmesidir. Daha özel olarak öz belirleme kuramı çerçevesinde lise öğrencilerinin öğrenmeye yönelik anne ve baba desteği algılarının çevrim içi öğrenmeye yönelik hazırbulunuşluklarını yordama düzeyleri incelenmiştir. Araştırmanın katılımcıları pandemi döneminde çevrim içi öğretime katılan 868 lise öğrencisidir. Araştırma kapsamında veriler çevrim içi bir form aracılığıyla çevrim içi öğrenmeye yönelik hazırbulunuşluk ölçeği ve öğrenmeye yönelik ebeveyn desteği ölçeklerinin anne ve baba formlarıyla toplanmıştır. Toplanan veriler betimsel analizler, Pearson korelasyonu ve çoklu doğrusal regresyon ile analiz edilmiştir. Betimsel bulgulara göre öğrencilerin çevrim içi öğrenme hazırbulunuşluklarının ve öğrenmeye yönelik anne ve baba desteği algılarının ortalamanın üzerinde olduğu belirlenmiştir. Ayrıca, öğrenmeye yönelik baba desteğinin öğrencilerin bilgisayar/internet öz yeterliği ile iletişim öz yeterliğinin anlamlı bir yordayıcısı olduğu görülürken öğrenmeye yönelik anne desteğinin ise öz yönelimli öğrenmenin anlamlı bir yordayıcısı olduğu görülmüştür. Son olarak öğrenmeye yönelik hem anne hem de baba desteğinin öğrenen kontrolü ve öğrenme motivasyonunun anlamlı yordayıcıları olduğu ortaya konulmuştur. İlgili alanyazında yüz yüze öğretim için elde edilen bulgulara benzer şekilde, lise düzeyinde sunulan çevrim içi öğretim için de öğrenmeye yönelik hem anne hem de baba desteğinin kritik rolü ortaya konulmuştur. Araştırmanın bulgularına dayalı olarak hem gelecek araştırmalara hem de uygulamaya dönük öneriler sunulmuştur.
Contribuição do uso de nanomateriais em matriz cimentícia por meio da manufatura aditiva visando uma construção sustentável
Authors: Corso Marla , Leles da Silva Maicon Douglas , Reitz Cardoso Flavia Aparecida Reitz Cardoso , Soto Herek Rezende Luciana Cristina , Marques Sastre Rodolfo
Published: October 2023

Reduzir o impacto ambiental e cumprir com o compromisso social, respeitando o meio ambiente para promover a sustentabilidade em processos produtivos tem sido debatido em diversos setores e, nos processos construtivos, a tecnologia é um aliado, pois a automatização e a inserção de componentes aos materiais, há uma diminuição de resíduos e melhora da qualidade das edificações.  Diante disso, este estudo teve por objetivo avaliar a construtibilidade e a extrudabilidade na construção civil por meio da inserção de grafite e óxido de grafeno em matriz cimentícia. Os filamentos cimentícios produzidos foram avaliados quanto aos parâmetros físicos, químicos e mecânicos. Os resultados obtidos apontaram que a inserção tanto de grafite quanto de óxido de grafite na matriz cimentícia não interferiu na extrudabilidade e na construtibilidade do material. . Foram obtidos valores de 9,34 MPa, 8,99 MPa e 8,91 MPa para a tração na flexão nas amostras acrescidas de 0,04% e 0,1% de grafite e 0,04% de óxido de grafeno, respectivamente. Quando avaliados quanto à compressão axial, as amostras que continham óxido de grafeno com 0,1% e 0,2% e amostra de referência tiveram os valores de 127.546,00 MPa, 127.350,05 MPa, 126.844,12 MPa, respectivamente. A amostra com 0,1% de grafite apresentou comportamento positivo com relação ao teste de tração à flexão, compressão e menor deformação após a impressão, tornando viável a adição dos nanomateriais em filamento cimentício para manufatura aditiva, de forma a possibilitar a produção de materiais mais resistentes.
What are the implications and impacts of current digital health interventions for children and adolescents with diagnoses ADHD? v1
Authors: not provided ajamisam
Published: October 2023

Attention deficit hyperactivity disorder (ADHD) has become increasingly relevant inthe wake of a technology centred and stimulation rich society. ADHD is aneurodevelopment condition which has a multifaceted effect on behaviour, workperformance and sleep. Most cases of ADHD are diagnosed at a young age. Thetreatment for ADHD is typically either medication or various modes of therapy,however many of these aim to only ameliorate the symptoms and not the underlyingcondition. In the evolving landscape of ADHD treatment, digital health interventions(DHIs) have received notable interest for their potential to address the diverse rangeof symptoms exhibited by children and adolescents with ADHD, and to deliver thisremotely. This review aims to examine the evidence and literature to identify patternsamongst interventions which might indicate features which facilitate success. Ourfindings show that DHIs hold promise in improving attention, executive functions, andADHD symptoms. A number of insights relating to outcome measures wereuncovered, highlighting the need for standardised outcome measures which align withthe diverse ADHD care ecosystem, and offer a more accurate representation oftreatment outcomes. Whilst we faced challenged in meta-analysis of the studies,reviews such as this play a crucial role in advancing the digital health space, andelucidating the need for validation and evidence for interventions. As is concluded bythis review, clinicians, innovators and researchers all have a role to play in improvingthe standards of evidence, in the hopes of providing safer, more user-centric andaccessible interventions.
Sputum Sample Processing for Single Cell Isolation and Live Recovery for Single Cell RNA Sequencing v1
Authors: D Limberis Jason , Nalyvayko Alina , Tomasicchio Michele , Jaumdally Shameem , pooran anil , Dheda Keertan , not provided john.metcalfe
Published: October 2023

Processing of clinical sputum samples for single live cell isolation for downstream applications.
PurificaciónPCR desde Gel v1
Authors: Antonio Márquez Diego
Published: October 2023

Método para purificar productos de PCR de hasta 1000 pb
AGRESSÕES SEXUAIS CONTRA CRIANÇAS E ADOLESCENTES NA REGIÃO METROPOLITANA DE RECIFE
Authors: Alves Maria Flávia , Almeida Adriana Conrado de , Silva Maria Beatriz Araújo , Silva Katyane Tabosa Mendes da , Silva João Alberto Marques da , Oliveira Filho José Marcos de Lira , Furtado Betise Mery alencar Sousa Macau , Bushatsky Magaly
Published: October 2023

Este estudo tem o objetivo identificar a incidência de agressões sexuais em crianças e adolescentes na região Metropolitana do Recife, PE no período 2020 a 2021, através de um mapeamento geográfico. Trata-se de um estudo ecológico, do tipo descritivo e exploratório de natureza quantitativa, utilizou-se técnicas de análise espacial de dados para investigar a existência de associação entre a localização geográfica e a ocorrência de agressões sexuais contra crianças e adolescentes na região metropolitana do Recife, PE. Os dados foram coletados em laudos, de exames periciais realizados no instituto de Medicina Legal Antônio Persivo Cunha. Destaca-se o Recife com a maior frequência relativa, tanto em 2020 como em 2021, com os valores de 37,64% e 32,03%, respectivamente, seguido de Jaboatão dos Guararapes e Paulista, contabilizando esses três municipios juntos aproximadamente 66% das notificações de agressões sexuais a crianças e adolescentes na Região Metropolitana do Recife em 2020 e 64,3% em 2021. Foi observado que 87% das vitimas eram do sexo feminino, em 30% o agressor era uma pessoa conhecida da vítima, em 77% dos casos as denuncias foram realizadas pelo menor ou pela genitora, em 41% a faixa etária prevalente foi de 11 a15 anos, o tipo de lesão com 77% dos casos foi a presença dos atos libidinosos e conjunção carnal. A elevada frequência de violência sexual contra crianças e adolescentes evidenciada neste estudo  vem  auxiliar na visibilidade desse grave problema de saúde pública e corroborar com a  necessidade de um olhar mais direcionado as políticas públicas preventivas.
A TERCEIRIZAÇÃO E OS DIREITOS SOCIAIS NA ERA DIGITAL
Authors: Silva Alex Dylan Freitas , Soares Carlos Henrique
Published: October 2023

O artigo aborda a crescente precarização do trabalho resultante das terceirizações na era digital, onde a subordinação do empregado pode ser dissimulada, comprometendo a configuração dos vínculos empregatícios. Explorando a interseção entre terceirizações e tecnologia, o estudo revela como a flexibilidade do trabalho é explorada para obscurecer a relação empregatícia. Nesse contexto, as crises econômicas exacerbam esse processo, levando à deterioração dos direitos sociais. O artigo destaca a importância de compreender essa dinâmica e propõe a necessidade de equilibrar a inovação tecnológica com a proteção dos direitos dos trabalhadores, a fim de preservar a dignidade e a estabilidade das relações de trabalho em meio às transformações digitais e às adversidades econômicas.
National Map of Security Threats as a Citizen Involvement Tool for Planning Safer Urban Public Spaces
Authors: Polko Paulina , Kimic Kinga
Published: October 2023

The National Map of Security Threats (NMST) implemented in Poland in 2016 is a GIS-based tool for digital crime and threat mapping involving citizens in the processes of shaping local security by reporting hazards in their neighbourhood (volunteered geographic information). The map—open for external users—is a source of information about common threats to the safety of human life and health, property, and public order, taking into account their spatial distribution, in the opinion of its users. Among 26 reportable hazards, there are categories related to (1) Traffic, (2) Greenery, (3) Water, (4) Demoralisation and Vandalism, (5) Poverty, (6) Alcohol and Drugs, and (7) Animals. The study aims to investigate which threats reported by citizens are the most represented on the NMST. The study covered data collected based on public access to the map in the period from January–December 2022. The analysis of the results allowed us to conclude that the most common threats belong to the following categories: (1) Traffic, (2) Alcohol and Drugs, and (3) Greenery. While the first two categories are not a surprise for researchers, and their importance is confirmed by other studies, the category of Greenery—its condition, damage, etc.—becomes more and more important, which was not confirmed in previous studies. Recognizing this is crucial to support processes of planning and designing more secure public spaces.
Entanglements of Improvisation, Conviviality, and Conflict in Everyday Encounters in Public Space
Authors: Horgan Mervyn , Liinamaa Saara
Published: October 2023

The everyday life of public space is characterised by many kinds of convivial, conflictual, and improvisational encounters between people of diverse backgrounds and experiences. Because public spaces are, in principle at least, freely accessible to all, they are of central importance to everyday life and intrinsically interesting to social scientists. This thematic issue brings together a range of disciplinary and interdisciplinary perspectives on everyday encounters in public space. In the introduction to this thematic issue, we appeal to urban scholars of all backgrounds to take the social life of public space seriously; as essential social infrastructure, public space is key to the collective well-being of city-dwellers, and it provides a crucial bridge between urban planning and the social sciences. Here, we briefly survey research on everyday encounters and introduce each of the contributions to the issue. While the articles in this issue are organised around the three core themes of conviviality, conflict, and improvisation, we argue for the entanglements of each within the everyday life of public spaces.
JUSTIFICATION OF INDICATORS OF FAILURE RESISTANCE OF THE AUTOMATED CONTROL SYSTEM OF THE CENTER OF OPERATIONAL MANAGEMENT OF THE ARMED FORCES OF UKRAINE
Authors:   The National Defence University of Ukraine named after Ivan Cherniakhovskyi, Katsalap V.O. , Omelyanchuk A.V. ,   General Staff of the Armed Forces of Ukraine, Sivak O.V. ,   General Staff of the Armed Forces of Ukraine
Published: October 2023

Modern approaches to substantiating the failure-tolerance indicators of the automated control system of the operational command center of the Armed Forces of Ukraine are based on the fact that any process of accumulating, collecting and storing information is invariably cyclic in nature. This essence determines the need to justify the indicators that allow data to be backed up in the automated management system. Such indicators of fault tolerance of the automated control system of the operational management center include: target recovery point - RPO; target recovery time - RTO; continuity of IT-services. The given indicators determine the effectiveness of the information support of the automated management system, which consists in providing management with timely and reliable information. This is especially relevant in the conditions of full-scale armed aggression of the Russian Federation against Ukraine and requires improvement of approaches to ensure the resilience of the automated control system of the operational command center of the Armed Forces of Ukraine. The model of IT-service continuity threats developed in the article makes it possible to compare classes of threats with their frequency of occurrence and typical means of protection. Based on them, it is possible to compare the corresponding indicators of scheduled recovery, in particular backup and archiving of data on a remote server (Crossite backup). In addition, the work considers approaches based on the application of financial indicators of the effectiveness of automation processes (Total cost of ownership), which allow to estimate the total costs of information technologies (equipment, tools, processes of supporting information systems.
TÜRK HALK MÜZİĞİNE ADANMIŞ BİR ÖMÜR: HAMDİ ÖZBAY
Authors: Doğan Can , İlgar Koray , Uludağ Erdal
Published: October 2023

Türk halk müziğinin birbirinden seçkin eserlerinin dinleyicilerle buluşturulduğu, birbirinden kıymetli sanatçıların sahne aldığı ve ustaların izinden giden çırakların yetiştiği TRT İstanbul Radyosu, halk müziğine kazandırdıkları bakımından oldukça önemli bir yere sahiptir. TRT İstanbul Radyosu sanatçıları aynı ortam içerisinde birbirlerinin eğitimine katkı sağladıkları gibi, aynı zamanda da geleneksel halk kültürünün taşıyıcılığını üstlenmişlerdir. Bu topluluk içerisindeki şahsiyetlerden birisi de kendi yöre kültürünü tanıtan, sazı ve sesiyle yurdun çeşitli folklorik değerlerini yansıtan bağlama sanatçısı Hamdi Özbay’dır. TRT İstanbul Radyosu’nda kadrolu bağlama sanatçısı olarak görev yapan Özbay, yaptığı plak çalışmaları ve derlediği türküler ile Türk halk müziği repertuvarına önemli eserler kazandırmış ve aynı zamanda aktif bir şekilde koro şefliği yapmıştır. Bu çalışmada, Hamdi Özbay tarafından TRT repertuvarına kazandırılan türkülerin ele alınması, Özbay’ın biyografisi ve sanatçı kimliği, bağlama icracılığı ve eğitimciliği, TRT repertuvarına kazandırdığı türkülerdeki makam dizileri, form ve usul yapıları hakkında bilgi verilmesi amaçlanmıştır. Nitel araştırma yöntemi doğrultusunda yapılandırılan bu çalışmada Hamdi Özbay’ın biyografisine, sanatçı kimliğine ve derlediği türkülere ilişkin verilerin elde edilmesinde literatür tarama, doküman inceleme ve görüşme tekniklerinden yararlanılmıştır. Sanatçının bağlama icracılığının değerlendirilmesi ve ortaya koyulması aşamasında ise içerik analizi yöntemi kullanılmıştır. Son aşamada ise çalışma kapsamında işlenerek bulgulara dönüştürülen veriler betimsel analiz yöntemiyle yorumlanarak sonuçlandırılmıştır.
Distribution of connexin 43 in the human pineal gland
Authors: Sufieva Dina A. , Fedorova Elena A. , Yakovlev Vladislav S. , Grigor’ev Igor P.
Published: October 2023

BACKGROUND: Connexin 43 (Cx43) is one of the important gap junction proteins of astrocytes and is necessary for intercellular communication. To date, data on gap junctions in the human pineal gland are limited, and Cx43 has not been examined in this organ.
AIM: This study aimed to investigate the distribution of gap junctions in the human pineal gland by simultaneous detection of Cx43 and the astrocyte marker glial fibrillary acidic protein (GFAP).
METHODS: Fixed and paraffin-embedded samples of the human pineal gland (n=4) were used. The study participants were between 19 and 34 years old. For the simultaneous detection of Cx43 and GFAP in the human pineal gland, immunohistochemistry was used, followed by analysis using an LSM 800 confocal laser scanning microscope (Carl Zeiss, Germany).
RESULTS: For the first time, our immunohistochemical study showed the presence of Cx43 in the human pineal gland. The confocal microscopy with double immunolabeling of Cx43 and GFAP visualized the individual clusters of Cx43-containing structures that were undistinguishable under transmitted light microscopy and showed the localization of the Cx43 on the membrane of astrocytes.
CONCLUSION: The proposed method makes it possible to determine Cx43-positive structures in human pineal tissue, which are localized mostly in the area of astrocyte processes.
Prevention of postoperative pain after total hip arthroplasty in patients with proximal femur fractures
Authors: Han H. Zh. , Akhtiamov I. F. , Ardashev S. A. , Karimov M. Yu.
Published: October 2023

Introduction Proximal femur fractures can be associated with nailing and total hip arthroplasty (THA). Treatment of elderly inpatients necessitates adequate postoperative pain relief. Obese patients require specific inpatient and outpatient treatments.

The objective was to evaluate the effectiveness of pain relief in obese patients at the stages of rehabilitation after primary THA performed for a proximal femur fracture.

Material and methods VAS score was compared in two groups of 60 clinical cases to evaluate the effectiveness of postoperative multimodal pain relief using the author's method.

Results Comparable results of an effective and stable pain relief were obtained in the two groups by the time the patient was discharged from the hospital 5-6 days after THA. Multimodal analgesia with a glucocorticosteroid injected in the projection of the sacroiliac joint provided an effect being greater by 29 % than with use of opioids after two postoperative days and by 11 % after five postoperative days.

Discussion Old age, comorbidities are associated with optimal surgical strategy. THA in patients with extra-articular proximal femur fractures can improve the rehabilitation potential early after surgery and general clinical and functional results providing high quality of life in the late rehabilitation period.

Conclusion THA demonstrated a stable positive effect of pain relief in the study group of patients with proximal femur fractures, regardless of the weight and the height. Positive dynamics in pain relief was seen in patients with elevated BMI of any gradation, including those with BMI ≥ 40.
Clinical profile of hemophilia children admitted in a tertiary care hospital in South India: a cross sectional study
Authors: Vantaku Venkata Vijayalakshmi , K. Jhansi Padma , M. Madan Mohan , D. Manikyamba
Published: October 2023

Background: Hemophilia is a rare inherited genetic blood disorder that needs a high index of suspicion and appropriate laboratory facilities for diagnosis. Unfortunately, it has not received the same patronage as other bleeding disorders like thalassemia and sickle cell anemia. Its management is expensive and requires lifelong treatment.
Methods: This is a hospital-based cross-sectional study done at a hemophilia treatment center in a tertiary hospital in South India to study the clinicoepidemiological profile and complications in hemophilia children admitted during the period of January 2022 to June 2023.
Results: 40 children with hemophilia were included in the study, and all of them had Hemophilia A with the majority being of severe type (62.5%). The mean age of diagnosis was 10 months. Hemarthrosis was the presenting complaint in about 50 % of children at admission while the majority had bruises and ecchymosis as clinical presentation at the time of first diagnosis (40%). 5 children tested positive for inhibitors among those tested. Intracranial hemorrhage was the most common occurring complication (17.5%). Knee (60%), elbow (47.5%) and ankle (40%) were the most common target joints.
Conclusions: There is a need for awareness of this disease among clinicians and people for appropriate diagnosis. The government should ensure the availability of factor replacement therapy and other treatment modalities even at District hospitals for easy accessibility of patients. Management goals should shift from on-demand therapy to prophylactic therapy for hemophilia children for better living standards and prevent complications like arthropathy in these patients.
A study of etiological and clinico-hematological profile of pancytopenia in children in a tertiary care hospital
Authors: Panda Priyabrata , Behera Jnanindranath , Nanda Chumki Rani
Published: October 2023

Background: Pancytopenia is a disorder in which all three major formed elements of blood are reduced below the lower limit of normal for the age and sex. Pancytopenia is a striking feature of many serious life-threatening illnesses ranging from simple drug-induced bone marrow hypoplasia, and megaloblastic anemia to fatal bone marrow aplasia and leukemias. In India, pancytopenia causes vary and still are more varied among the pediatric population. So, the present study was carried out to evaluate the various causes and clinic-hematological factors of pancytopenia in the pediatric age group.
Methods: It was a hospital-based analytical cross-sectional study conducted in the department of pediatrics, SVPPGIP & SCB Medical College, Cuttack from September 2016 to October 2018. A total of 106 children between 6 months to 18 years with Pancytopenia were enrolled in our study. Bone marrow aspiration was conclusive in most of the cases. All data were analyzed using SPSS. Chi-square test was used to analyze any association and a p-value of <0.05 was considered significant.
Results: Out of 106 patients, the majority were 10-14 years old. Female to male ratio was 1.4:1. The most common etiological factors were ALL (58.5%), Aplastic Anemia (19.8%), and others. Fever and Weight loss were the most common presenting symptoms. The most common signs were Pallor and Hepatomegaly.
Conclusions: The present study concludes that detailed primary hematological investigations along with bone marrow aspiration are really helpful for understanding the disease process, diagnosing the etiology of pancytopenia, and helpful in planning further investigations and management of pancytopenia patients.
Clinical outcome of babies born through meconium stained liqour
Authors: Parveen Akhila , S. Udayakumar , K. Pushpalatha , N. Karthik R.
Published: October 2023

Background: Meconium aspiration syndrome (MAS) is as a  result of  aspiration of meconium-stained amniotic fluid antepartum or postpartum in term or near-term infants resulting in respiratory morbidity of varying severity. The present study was conducted to assess the clinical outcome of babies born through meconium stained liquor.
Methods: This is a prospective observational study of babies born through meconium stained liquor at ESIC Medical College and Post Graduate Institute of Medical Science and Research over a period of 18 months from March 2021 to August 2022.
Results: Majority of the babies were born through thin MSL. The highest incidence of MSL is seen in term babies. Normal vaginal delivery was the predominant mode of delivery. Thick MSL babies had low APGAR score at 1min .Majority of the thick MSL group had moderate to severe respiratory distress. Thick MSL babies required invasive mechanical ventilation compared to thin MSL group. Thick MSL study group had moderate to severe meconium aspiration syndrome compared to thin MSL study group. Perinatal depression was the most commonly associated complication in this study. Sepsis and PPHN were the complications that lead to mortality among the study group. Higher morbidity was seen in thick MSL group. The overall mortality was 1.6% and morbidity 55.2%.
Conclusions: Thick meconium stained amniotic fluid is associated with increased risk perinatal depression, persistent pulmonary hypertension, sepsis, severe meconium aspiration syndrome and mortality.
Is it a teratoma? is it a nephroblastoma? no, it is a teratoma with nephroblastoma: a rare tumor in pediatric oncology
Authors: Smith Erlyn , Montilla Adriana , Krishnan Chandra
Published: October 2023

Mixed extragonadal teratoma with malignant nephroblastoma (TWN) is an exceptionally rare and complex combination of solid tumors which has been referred to as “teratoid Wilms tumor,” “teratoid nephroblastoma,” or “teratoma with nephroblastoma.”  Here we report a seven-year-old male who presented with a large retroperitoneal mass outside of the right kidney with lung metastases and diagnosed with a malignant mixed germ cell tumor with mature teratoma and extensive malignant nephroblastoma. Our case report highlights the controversial pathogenesis of this rare tumor and describes the variety of treatment regimens delivered for this type of tumor.  In this case report, we described a young child with metastatic TWN who was successfully treated with multimodal approach based on Wilms tumor management including surgery, chemotherapy, and radiation.
Kikuchi Fujimoto disease with macrophage activation syndrome, seizures, and pleuritis in a young child
Authors: Otiv Madhumati , Shah Pawan , Botre Abhijeetbotre , Subramaniyan Kannan
Published: October 2023

Kikuchi Fujimoto disease (KFD) is rare in children and generally a benign, self-limiting disease that rarely runs a complicated course. We report a rare case of KFD in a young girl that had a complicated course with macrophage activation syndrome (MAS), posterior reversible encephalopathy syndrome (PRES) and pleuritis needing ventilatory support and prolonged immunosuppression with good recovery. This illustrates KFD can rarely also have unusual presentation needing advanced immunosuppression and a careful follow up.
A rare case of juvenile primary lateral sclerosis
Authors: Agrawal Anjali O. , Pandya Jay , Morwal Abhijit , Dhanuka Ramkumar
Published: October 2023

Primary lateral sclerosis (PLS) is a rare, neurodegenerative disorder, which affects the upper motor neurons (UMN), predominantly the large pyramidal cells of corticospinal and corticobulbar tracts, common during fourth to fifth decade of life. Juvenile PLS is an autosomal recessive form with ALS2 gene mutation on 2q33.2 chromosome affecting infants and children. A 6-year-old girl presented with complaints of difficulty in walking and climbing stairs noticed by parents in the last 2 months and frequent falls associated with stiffness of lower limbs for 15 days with no other significant history. Central nervous system (CNS) examination was normal except for spasticity in bilateral lower with exaggerated lower limb reflexes with spastic gait. Baseline laboratory investigations were normal. Magnetic resonance imaging (MRI) brain and spine showed symmetrical signal abnormality along corticospinal tracts bilaterally. Diagnosis of primary lateral sclerosis was made after ruling out possible causes.
Arthrogryposis multiplex congenita in twin 1 of a twin pregnancy: case report
Authors: Dsouza Stephanie Rachel , Wasdev Abhey , Gowda Prashanth
Published: October 2023

Arthrogryposis multiplex congenita (AMC) is a rare congenital syndrome characterized by multiple joint contractures. It usually affects the joints of hands, wrists, elbows, shoulders, hips, feet, knees, jaw and back. This case report discusses a mild variety of AMC in a twin where the other twin had no musculoskeletal abnormalities. There has been no published case report of such a case in a twin delivery. Prompt recognition of the syndrome complex and early start of stretching exercises and physiotherapy is the mainstay treatment protocol to give relative contracture free mobility to the child.
Biopsy tract seeding in musculoskeletal sarcomas: myth or reality?
Authors: Shanmugam S. Subbiah , Aravind S.
Published: October 2023

Background: It is a common practice in oncology in general and musculoskeletal oncology that the biopsy tract must be resected together with the tumor while performing limb-sparing surgery. Our study aims to assess the need for routine excision of biopsy scars in musculoskeletal malignancies by analyzing the presence of tumor in the biopsy tracts.
Methods: We conducted a prospective study from January 2021 to April 2023, including 48 soft tissue and bone sarcoma patients. Neoadjuvant chemotherapy was administered to all cases of Ewings sarcoma and osteosarcoma. All of them underwent surgical resection with appropriate reconstruction. Biopsy tracts were sent separately and analyzed for tumor infiltration.
Results: Two of the 48 patients included in the study had tumor deposits in their biopsy tracts. One patient with undifferentiated pleomorphic sarcoma and another patient with high-grade myxoid liposarcoma had tumor seeding in their biopsy tracts.
Conclusions: The rate of biopsy tract seeding in our study was 4.2% (2 out of 48). Even though this might seem very less, it is still significant considering the rarity of bone and soft tissue sarcomas. Despite the low risk of tumor seeding, it is advisable to continue routinely excising the biopsy tract. Whether inappropriately placed biopsy tracts warrant an amputation instead of limb salvage is a question that will be best answered in the future with large-scale prospective randomized studies.
¿Cuáles son las destrezas futuras necesarias para una transición hacia las energías renovables? (What future skills will be transformed towards renewables?)
Authors: Goti Elordi Aitor ,   Universidad de Deusto, Akyazi Tugce ,   Universidad de Deusto, Oyarbide Zubillaga Aitor
Published: October 2023

¿Cuáles son las destrezas futuras necesarias para una transición hacia las energías renovables? quiere trasladar los resultados de RENSKILL que define cómo serán los perfiles ingenieriles de puestos de trabajo futuros vinculados a la sostenibilidad, demostrando un impacto social creciente, pudiendo influir en el diseño de programas de asignaturas de centros educativos, en la priorización de políticas formativas gubernamentales relacionadas con el ámbito de la sostenibilidad y en la orientación de los planes formativos de las empresas. // What future skills will be transformed towards renewables? seeks to disseminate RENSKILL’s results on how to define what profiles will be required for future engineering jobs linked to sustainability, demonstrating a growing social impact for being able to influence the design of school subject programmes, the prioritization of government training policies related to the field of sustainability and the orientation of companies’ training plans.
Reductıon of thermal tensıons and temperatures formed ın the trıbonodes and surfaces of the equıpment and tools used ın well workover and restoratıon works
Authors:   Azerbaijan State Oil and Industry University, Mustafayev Amir G. , Nasirov Chingiz R. ,   Azerbaijan State Oil and Industry University
Published: October 2023

The maintenance of equipment and tools used in the workover of oil and gas wells depends on keeping them in good working condition, maintaining the reliability, strength, and temperature endurance of the tool. To restore wells after an accident and bring them back into operation, it is necessary to speed up the drilling and repair work by choosing the right repair equipment and following the existing rules and regulatory documents. The cutting elements of tools working under high pressure and loads are deformed, a tense situation is created in the cutting – a destruction zone and high temperatures (1000–1200°C) occur because of corrosion in the triboknots. The stress-deformation state in the cutting-destruction zone causes the formation of microcracks in the working area of the tool. Microcracks grow after a certain period. Cutting elements are quickly worn, in some cases break and fail quickly. Such cases affect the structural composition of the cutting elements, an increase in temperatures; as a result, riveting occurs. In order to keep the equipment and tools used in the repair in normal working condition, adjusting the mode parameters is one of the important requirements, in addition to taking special care of them. Optimum results obtained in repair and restoration depend on the efficiency of the cutting-destructive tool, longevity, material selection, construction manufacturing technologies, tools that meet modern requirements, dimensions, weight, and internal condition of the well being restored. It is necessary to keep the heat generated in the moving parts of the tool at the required level for the safe performance of restoration work. The thermal regime of cutting and rock-destroying tools depends on the physical-mechanical properties of the objects subjected to destruction, and the effect of thermomechanical stresses generated on the contact surfaces of the tool and the amount of heat released from the working surface. Studying the problems related to heat issues will ensure the temperature tolerance of not only the repair equipment, but also the equipment and tools used in other areas of the oil-field industry.
Review of basic equations for evaluating drilling efficiency
Authors:   Azerbaijan State Oil and Industry University, Mehtiyev Rafail K. , Tanriverdiyev Yusif A. ,   Azerbaijan State Oil and Industry University
Published: October 2023

The main goal of the reviewed article is to provide statistically determined relationships between the parameters of disintegration processes and the properties of rocks. The results of theoretical and experimental studies are discussed and analysed in the article. In relation to drilling, the formulas of drilling speed, depending on various parameters as an indicator that fully reflects the efficiency of the process, are given and compared. Thus, the drilling speed for percussion drilling is related to the characteristics of the rock and, at the same time, taking into account the constructional characteristics of the drilling tool. In percussion drilling, a new formula for drilling speed is presented, considering each impact and the frequency of the impact. The expression for the drilling speed was determined taking into account the degree of crushing of the rock matrix during drilling. Thus, the drilling speed is determined by considering the contact strength of the rock being drilled in the mechanical drilling method. The distribution of the stress state in the drilling zone was determined. Also, the shape and development characteristics of the cracks formed in the rock during the operation of the drilling tool (especially the dynamic percussions of the tool in the bottom zone of the well) were investigated. It should be noted that the energy intensity of the drilling process in the rock was determined by studying the next stages of the process of breaking the rock. The technical and economic indicators of the drilling works have been evaluated. Corresponding mathematical formulas are presented as a reliable calculation of drilling rates. The relevant mechanical and geophysical properties of the excavated rocks were considered. In the article, the drilling tools are selected depending on the drilling method, physical-mechanical properties of the rocks and geological conditions of the rock mass. The results of the obtained studies can be used in the design of the technological parameters of the drilling. The observations and results expressed in the article have a theoretical and practical aspect.
The method for calculating technological indicators in the development of gas wells while considering the thermobaric and thermodynamic conditions within the “reservoir-well” system
Authors:   Azerbaijan State Oil and Industry University, Gadasheva Elmira V. , Novruzova Sudaba H. ,   Azerbaijan State Oil and Industry University
Published: October 2023

Considering the substantial prevalence of gas fields in the pool of developed fields, their development requires specialized approaches with the primary objective of optimizing the production process. The effectiveness of gas field development hinges on achieving the highest possible gas recovery factor. Achieving a high limit of the ultimate return of gas fields relies on decisions that vary depending on the precision of design estimates carried out at different stages of development and their timely execution. The accuracy of such estimates is, if possible, directly contingent on the thorough consideration of geological, technical, and technological factors when formulating methods for determining field development and operation indicators. Given the above considerations, this article proposes a methodology for determining the technological indicators of gas reservoir development, which enables to anticipate changes in reservoir pressure, temperature, and porosity of the gas reservoir, while accounting for the gas-dynamic interplay within the “reservoir-well” system in the depletion phase. The developed approach makes it possible to reliably ascertain reservoir development metrics by factoring in well conditions, temperature distribution within the reservoir, and reservoir deformation. In addition, it facilitates the necessary assessment for determining optimal well operations in light of reservoir conditions.