bluuebunny/crossref_metadata_2025 huggingface dataset:
Is Our Attachment Hurting Us? Unraveling the Associations Between Partners' Attachment Pairings, Negative Emotions During Conflict, and Intimate Partner Violence
Authors: Pudelko Apollonia Helena , Ramos Brenda , Emond Marianne , Péloquin Katherine , Daspe Marie‐Ève
Published: February 2025

Attachment insecurities and heightened negative emotions during conflict are significant risk factors for intimate partner violence (IPV). Previous research mainly examined each partner's attachment separately and overlooked negative emotions as a mechanism in the attachment–IPV link. This dyadic observational study conducted among 178 young adult couples examined (1) the interplay between both partners' attachment (i.e., pairings) in association with their IPV perpetration and (2) the contribution of negative emotions during a conflict discussion in these associations. Results revealed that one's avoidance was positively linked with their IPV only when their partner showed low levels of avoidance. One's avoidance was also indirectly associated with their own IPV through their own negative emotions, and to their partner's IPV via their partner's negative emotions. Finally, one's anxiety was indirectly linked with their own IPV through their own negative emotions. Findings support prevention and intervention strategies for IPV that target attachment and negative emotions.
Care Work, Labour Control and the Gendered Social Reproduction of a Semi‐Landless Class in 19th Century Sweden
Authors: Uppenberg Carolina
Published: February 2025

This article shows how the reproductive work in the households of the semi‐proletarianized Swedish group termed crofters (Sw: torpare) ensured subsistence for the crofters and increased capital accumulation for large landowners. Crofters lived under partly proletarianized, partly feudal conditions and their labour organization illuminates the proletarianization during the 19th century. Through two concepts from the field of Marxist‐feminist social reproduction theory, Alessandra Mezzadri's ‘value theory of inclusion’ and Nancy Fraser's ‘contradictions of care’, it is shown how the landowner externalized the costs of reproductive care work to be absorbed by the crofter households. This increased labour control, and the reproductive labour of the crofter household increased the value of the land for the landowner, allowing for capital accumulation. The analysis shows a process in which the crofter institution underwent a formal subsumption of labour, keeping the forms intact but increasingly contributing to capital accumulation through the organization of reproduction.
Retrospective Review of 2851 Female Patients With Telogen Effluvium: A Single‐Center Experience
Authors: Karakoyun Ömer , Ayhan Erhan , Yıldız İsmail
Published: February 2025

Objective

Telogen effluvium, the most common cause of diffuse and non‐scarring alopecia in women, is frequently diagnosed in dermatology outpatient clinics and can be caused by various etiological factors such as medications, trauma, emotional, and physiological stress. In patients presenting with complaints of telogen effluvium, we aimed to investigate abnormal levels of serum ferritin, vitamin B12, folic acid, thyroid function tests, and hemoglobin and determine which of these abnormal values might be significantly associated with telogen effluvium.

Material and Methods

In this study, 2851 female patients diagnosed with telogen effluvium who applied to the Dicle University Dermatology outpatient clinic between January 1, 2010 and June 30, 2024 were retrospectively evaluated. The relationship between these laboratory abnormalities and telogen effluvium, as well as their significance in different age groups, was analyzed using the SPSS‐27.0 program. Associations were analyzed using Kolmogorov–Smirnov test, dependent t‐test, Wilcoxon test, Pearson chi‐square (χ2) test, Yates chi‐square (χ2) test, Fisher chi‐square (χ2) test analysis, Mc‐Nemar test, Pearson/spearman correlation analysis, and logistic regression analysis. A p value of < 0.05 was considered statistically significant.

Results

The mean age of 2851 female patients included in our study was 26.33 years, 12.8% (n = 366) were under 18 years of age, 83.5% (n = 2380) were between 18 and 45 years of age, and 3.7% (n = 105) were over 45 years of age. Hemoglobin values were determined in 2496 of 2851 patients and values below the reference range were found in 317 patients (11.1%). Ferritin was found to be low in 1123 (46.5%) of 2413 patients. Vitamin 12 deficiency was detected in 150 (5.8%), folic acid deficiency in 8 (0.6%), and iron deficiency in 685 (29.5%) patients. As can be seen in our study, deficiency of laboratory parameters, especially ferritin and serum iron, is a common finding in female patients presenting with TE.

Conclusion

This study showed that biochemical tests, complete blood counts, and hormonal tests are important tools in investigating the etiology and guiding the treatment in patients diagnosed with telogen effluvium, as various etiological factors may be present. Furthermore, it was determined that parameters such as vitamin B12, ferritin, TSH, and T3 hold varying levels of importance during significant phases of women's physiological development, such as adolescence and post‐menopausal periods.
Clinician Perspectives on Using Plastic Cannula for Vascular Access in Haemodialysis: Outcomes of a National Web‐Based Survey
Authors: Smith Vicki , Schoch Monica
Published: February 2025

Background

Plastic cannulae were introduced into Australia over a decade ago as a safer alternative to metal dialysis needles for arteriovenous fistula cannulation, decreasing the risk of infiltration resulting in haematoma formation, bruising, and pain for patients.

Objectives

To explore the uptake and current practices for using plastic cannulae for vascular access in Australian dialysis units.

Design

A 31‐item exploratory descriptive web‐based cross‐sectional survey.

Participants

Renal clinicians who cannulate arteriovenous fistulae or arteriovenous grafts for haemodialysis in Australian haemodialysis units.

Results

A total of 185 clinicians responded to the questionnaire, with the majority of respondents from the Australian east coast Australia, specifically Queensland (36%, n = 66), New South Wales (27%, n = 50) and Victoria (26%, n = 48). Sixty‐five percent of respondents were either registered nurses (47%, n = 88) or clinical nurse specialists (18%, n = 34). Of 140 participants who reported plastic cannula availability, only 62 (44%) used them personally. Plastic cannulae were mainly used with new (n = 55/65, 85%) and established (n = 56/60, 90%) vascular access, but rarely in home haemodialysis (n = 7/60, 11%). Plastic cannula was commonly used for the first 2 weeks with new fistula, then switched to metal needles due to high cost, however 41% (n = 22/54) reported that decisions on long‐term cannula use was based on patient clinical needs. Training and gauge of cannula varied by state, with 16‐guage the most common.

Conclusion

Plastic cannula use is increasing across Australia, but cost and training barriers still exist. Nevertheless, plastic cannulae remain a viable alternative to metal needles.
Cultural Generalizability of the False Signaling Theory: A Replication Study Using a Japanese Sample
Authors: Zhao Xinyu , Watamura Eiichiro
Published: February 2025

Hypocrites are generally viewed unfavorably. According to the false signaling theory, this is because a hypocrite's condemnation falsely manipulates observers into believing in their moral goodness. However, since the false signaling theory has not been tested in cultures other than that of the United States, its cultural generalizability remains unclear. This study replicated two experiments comparing evaluations of hypocrites with those of transgressors and liars (Experiment 1, n = 583) and those of transgressors with those of honest hypocrites (Experiment 2, n = 509) using a Japanese sample. The results generally support the false signaling theory as hypocrites' condemnation also attracted harsh criticism among Japanese participants. However, our results also suggest differences in the definition of false signals between Japanese and U.S. samples. The Japanese participants believed that liars were as morally wrong and hypocritical as hypocrites. We speculate that such cultural differences may stem from the high‐context culture and discuss some directions for future research.
The Moravian Society in the Era of the Nonterritorial Autonomy (1905–1918): Civic Emancipation and National Life as Two Sides of the Same Coin
Authors: Pokludová Andrea , Kladiwa Pavel
Published: February 2025

The Moravian Compromise of 1905 introduced important elements of nonterritorial autonomy (NTA) into the Austrian province of Moravia with a national separation of education, school administration, constituencies and parliamentary mandates. After the introductory passages that outline the basic aspects of the Moravian situation at the end of the 19th century, the first part of the article presents all four acts that constituted the Moravian Compromise and sketches their practical implementation. The second part examines public life and municipal politics in the Moravian ethnically mixed town of Olomouc in the period preceding the Compromise as well as following the installation of the NTA system. It shows that ordinary civic life was increasingly intertwined with public life, including national agitation, even in the last decades before the introduction of the nonterritorial national autonomy, as a direct consequence of the growing intensity of social emancipation and communication. In the third and final part of the study, we outline our understanding of the impact of national identity on the Moravian (and, especially, Olomouc) population and of the role of national identity in everyday life.
Genomic prediction with NetGP based on gene network and multi‐omics data in plants
Authors: Zhao Longyang , Tang Ping , Luo Jinjing , Liu Jianxiang , Peng Xin , Shen Mengyuan , Wang Chengrui , Zhao Junliang , Zhou Degui , Fan Zhilan , Chen Yibo , Wang Runfeng , Tang Xiaoyan , Xu Zhi , Liu Qi
Published: February 2025

Genomic selection (GS) is a new breeding strategy. Generally, traditional methods are used for predicting traits based on the whole genome. However, the prediction accuracy of these models remains limited because they cannot fully reflect the intricate nonlinear interactions between genotypes and traits. Here, a novel single nucleotide polymorphism (SNP) feature extraction technique based on the Pearson‐Collinearity Selection (PCS) is firstly presented and improves prediction accuracy across several known models. Furthermore, gene network prediction model (NetGP) is a novel deep learning approach designed for phenotypic prediction. It utilizes transcriptomic dataset (Trans), genomic dataset (SNP) and multi‐omics dataset (Trans + SNP). The NetGP model demonstrated better performance compared to other models in genomic predictions, transcriptomic predictions and multi‐omics predictions. NetGP multi‐omics model performed better than independent genomic or transcriptomic prediction models. Prediction performance evaluations using several other plants' data showed good generalizability for NetGP. Taken together, our study not only offers a novel and effective tool for plant genomic selection but also points to new avenues for future plant breeding research.
Genetic Variation and Phenotypic Plasticity of Leaf Minimum Water Conductance in Temperate Tree Species
Authors: Wang Songwei , Hoch Günter , Hopf Sven , Kahmen Ansgar
Published: February 2025

The survival time of trees under drought is intimately linked to leaf minimum water conductance on the leaf surface (gmin), which determines the residual water loss of trees after maximum stomatal closure. Considerable interspecies variation of gmin in trees has been documented, but intraspecific variation resulting from genetic variation (G) and phenotypic plasticity (E) remains unclear. We measured the temperature response (T) of gmin in different provenances of four temperate tree species growing in three common gardens differing in water availability and assessed G, E and G × E of gmin and T. Additionally, we explored how leaf cuticular and stomatal traits are related to the intraspecific variation of gmin. For all species, our results showed strong T, low G and high E for gmin. Interestingly, E was more pronounced in deciduous angiosperm trees than in evergreen conifers. Surprisingly, there was significant E × T in some species. Contrary to our expectation, we found no significant effect of leaf stomatal and cuticular traits on gmin. Our study suggests that E is the most potent driver of intraspecies variation of gmin, possibly contributing to the acclimation of deciduous trees to a future hotter and dryer climate.
Public‐private or public‐public? Exploring factors affecting private participation in China's public‐private partnerships
Authors: Qin Shikun , Zhao Jerry Zhirong
Published: February 2025

Public‐private partnerships (PPPs) in China rose sharply after 2014. However, there are growing concerns regarding the predominance of state‐owned enterprises (SOEs) as partners of PPP projects. The participation of private companies in China's PPP has been decreasing in recent years despite the promotion of the national government. Based on the transaction cost theory, we construct an explanatory framework of private participation that contains government, market, transactional context, and project dimensions. Employing a city‐level panel data containing rich information about partner structure, our analysis shows that strong government capacity and credibility, active local private sector, and proximity both geographically and politically to the national power center promote private participation. In addition, projects with lower investment levels and longer duration tend to have higher private participation. Our findings offer insights into enhancing private infrastructure investment, relevant for both neoliberal and non‐liberal countries facing budget constraints.
A four‐dimensional peabody of constant width
Authors: Arelio Isaac , Montejano Luis , Oliveros Deborah
Published: February 2025

In this paper, we present a unique four‐dimensional body of constant width based on the classical notion of focal conics.
Multilevel Relaxation Model for Describing Magnetization Curves of Nanoparticles
Authors: Lobachev A. V. , Chuev M. A.
Published: February 2025

A theory has been developed to describe the magnetization curves of an ensemble of single-domain particles. This theory includes their temperature-induced excitations and is in fact a generalization of the two-level Stoner–Wohlfarth model and its relaxation version, as well as a multilevel relaxation model for describing Mössbauer spectra. A basically new aspect of this theory is the solution of a system of differential equations for nonequilibrium populations of stochastic states. The resultant model includes the physical mechanisms for the formation of magnetization curves of nanoparticles in real situations and describes self-consistently the qualitative features of the transformation of these curves under the variation of the temperature and the strength and direction of an external field.
Baby Sleep Project Protocol: a realist evaluation of an intervention to reduce preventable infant mortality
Authors: Pease Anna , Lambert Becky , Ingram Jenny , Bradley N , Fleming Peter , Blair Peter S , Farr Michelle
Published: February 2025

Introduction

In the UK, approximately 300 infants each year die suddenly and unexpectedly, with most deaths remaining unexplained. Population-wide ‘Safer Sleep’ messages have brought rates down but remaining deaths now predominantly occur within families experiencing poverty. Many of these deaths may be preventable as the majority have known, avoidable risks present. New resources and tools for health professionals and families have been developed to address modifiable barriers to implementing safer sleep advice in this priority group of families. This study aims to understand how the Baby Sleep Project resources work to improve the uptake of safer sleep advice, including for whom, and in what contexts they work best.

Methods and analysis

Realist evaluation will be used, including both qualitative and quantitative methods. Data will be collected both pre- and post-health professional training in the new resources. We will invite neonatal staff, health visitors and family nurse partnerships nurses, and primary caregivers of infants to take part. We will carry out qualitative interviews with health professionals and caregivers. Quantitative surveys looking at implementation for health professionals, changes in infant care knowledge and practice, and parenting self-efficacy will be conducted with caregivers. Mechanisms of action, contexts and outcomes from the new resources will be tested against the initial programme theory. The findings from this research will inform evidence-based explanations of how to improve the uptake of health advice in priority populations.

Ethics and dissemination

The study was given a favourable opinion by the South West—Frenchay Research Ethics Committee (ref: 23/SW/0119). We will publish our findings in academic journals and talk about them at conferences. We will make sure the people who took part in the study hear about them first. If the resources are shown to be useful, we will work with charities and the National Health Service to roll them out across the whole of the UK.

Trial registration number

NCT3364337
.
Mismatch between climate-based bioenergetics model of fish growth and long-term and regional-scale empirical data
Authors: Grabda Elise E , Flood Peter J , King Katelyn B. S. , Breck James , Wehrly Kevin E. , Alofs Karen
Published: February 2025

Climate-driven decreases in body size have been documented for a variety of taxa and proposed as a universal response to climate change. However, empirical support among taxa, including fishes, has been mixed, with some fishes growing larger at higher temperatures, and causal mechanisms for faster or slower growth under debate. We simulated effects of climate warming on bluegill (Lepomis macrochirus) growth and consumption and used linear regression and boosted regression trees (BRTs) to model length-at-age for bluegill from Michigan lakes from 1945-2019. Bioenergetics models showed bluegill growth and consumption both increase under climate warming. In contrast, linear regression revealed that bluegill ages 1-4 decreased (-0.20 to -0.55 mm/year) in mean length-at-age and that ages 5-8 increased or did not statistically change. BRTs demonstrated that growth had a unimodal relationship with surface water temperature and degree days, peaking at intermediate values. This mismatch between simulations and empirical data may be from increased recruitment leading to increased food limitation at higher temperatures. Future research should empirically test this hypothesis and assess the consequences for ecosystem functions and services.
Reheating dynamics in inflationary cosmology: insights from $$\alpha $$-attractor and $$\alpha $$-Starobinsky models
Authors: Germán Gabriel
Published: February 2025

Reheating in inflationary cosmology is essential for understanding the early universe, influencing particle production, thermalization, and the primordial power spectrum. Crucial quantities defined during the reheating epoc, such as the equation of state parameter

$$\omega _{re}$$

ω

re

, reheating temperature

$$T_{re}$$

T

re

, and the number of e-folds

$$N_{re}$$

N

re

, affect inflationary observables like the scalar spectral index

$$n_s$$

n
s

and the tensor-to-scalar ratio r. We analyze two classes of inflationary models: generalized

$$\alpha $$

α

-attractor models and the

$$\alpha $$

α

-Starobinsky generalization. These models, motivated by supergravity and string theory, exhibit attractor behavior, ensuring strong predictions and have been studied extensively before. An important novelty of this study, compared to previous works, is the inclusion of an analytical expression for the reheating temperature,

$$T_{\text {re}}$$

T
re

, which makes it a dynamical quantity. This is crucial for determining all the cosmological quantities analyzed in this work. Our results show a universal scaling behavior for a tightly bounded

$$T_{re}$$

T

re

in both models. We believe this is the first time that

$$T_{re}$$

T

re

is so closely determined. This work complements previous Bayesian and numerical studies by providing detailed numerical and analytical insights into the evolution of cosmological observables and reheating parameters, offering also constraints on inflationary models based on observational data.
Normalized Laplacian Spectral Ratio of Graphs
Authors: Cai Min , Wang JiaJia , Zhang Shumin
Published: February 2025

The normalized Laplacian spectrum of a graph is the eigenvalues of the associated normalized Laplacian matrix. The quotient between the largest and the second smallest normalized Laplacian matrix eigenvalues of a connected graph, is called the normalized Laplacian spectral ratio. Some bounds of the normalized Laplacian spectral ratio of a connected graph are considered. In the paper, we improve a relation of the normalized Laplacian spectral ratio of regular graphs, and we obtain the effects on the normalized Laplacian spectral ratio of a graph by the Operations.
Additive Screening of LFP/graphite Pouch Cells for High Temperature Cycling at 70 °C
Authors: Azam Saad , Black William , MacLennan Holden , Eldesoky Ahmed , Dahn J. R.
Published: February 2025

In recent years, LiFePO4 (LFP)/graphite cell chemistry has gained renewed interest for commercial use in electric vehicles and grid energy storage due to its low cost, utilization of an abundantly available transition metal, and better intrinsic safety characteristics. However, LFP/graphite cells exhibit inferior cycling performance at high temperatures compared to some Li[NixMnyCoz]O2 (NMC) type materials. This study evaluated three classes of electrolyte additives - vinylene carbonate (VC), fluoroethylene carbonate, and prop-1-ene-1,3-sultone to improve the lifetime of LFP/graphite pouch cells stored and cycled at 60 °C and 70 °C, respectively. Co-additives such as methylene methanedisulfonate, 1,3,2-dioxathiolane-2,2-dioxide, and tris(trimethylsilyl) phosphite were also screened. Once the cells completed their respective testing, cell components were characterized via EIS, μXRF, and NMR. After screening 25 electrolyte combinations, it was found that VC at 4−5% (w/w) is the most effective additive for improving the lifetime of LFP/graphite pouch cells during cycling and storage at high temperatures. This improvement is due to the formation of an efficient negative electrode SEI and the limitation of Fe dissolution from the positive electrode, which maybe responsible for catalyzing further lithium inventory loss. The efficacy of 4−5% VC is largely due to having residual VC remaining in the electrolyte after the formation cycle.
Measuring Flow: Refining Research Protocols That Integrate Physiological and Psychological Approaches
Authors: Wonders Martin , Hodgson Dan , Whitton Nicola
Published: February 2025

Measuring flow, an optimal mental state defined by intense focus and immersion, can provide valuable insights into research on human engagement. However, a review of 69 studies identified significant methodological issues that could be undermining progress in this area of research. We discovered the use of eight nonvalidated psychological flow verification instruments (used in 33 studies), ambiguity and a lack of transparency in the interpretation and reporting of the verification results (36 studies), and a lack of screening of participants with only two studies screening for a disposition to experience a flow state. Additionally, despite the balance of challenge and skill being an essential precondition for inducing a flow state, 33 studies did not appropriately match flow‐inducing activities to participant’s skill levels. These issues with measuring flow through self‐assessment make it impossible to accurately validate hypothesised flow states using physiological approaches. To address these limitations, we propose a set of research protocol guidelines for integrating physiological and psychological measures to triangulate flow indicators. This provides a robust research framework that will allow the identification of physiological measures of flow that can provide a real‐time objective alternative to subjective self‐assessment instruments.
Environmental Responsibility, Environmental Concerns, and Green Banking Adoption in Pakistan: Using the Unified Theory of Acceptance and Use of Technology
Authors: Majeed Abdul , Rasheed Abdul
Published: February 2025

The banking industry has been criticized for its role in contributing to climate change, whether directly or indirectly. In response to these concerns, the “green banking” concept has emerged as a proactive approach to mitigating banks’ environmental impact. However, there is still limited research on adopting green banking from customers’ perspectives in developing countries, notably Pakistan. Therefore, this research is aimed at exploring and examining the factors influencing customers’ intention to adopt green banking and their usage behavior by employing the unified theory of acceptance and use of technology (UTAUT). The UTAUT model was integrated with customers’ environmental responsibility and environmental concerns to identify the primary drivers of green banking proliferation. The research was carried out in Lahore, Pakistan, and involved 280 customers from private banks, and a convenience sampling technique was employed to gather data. The empirical findings have revealed that facilitating conditions and performance expectancy are the primary drivers of green banking proliferation, followed by environmental responsibility and environmental concerns. The study has discovered that behavioral intention plays a significant mediating role in the relationship between performance expectancy, effort expectancy, social influence, facilitating conditions, environmental responsibility, environmental concerns, and green banking usage behavior. The banking professionals should consider these factors when formulating and advancing green banking products or services and strategies to encourage the widespread adoption of green banking in conventional markets, fostering hope for a more sustainable future. The study provides new insights into customers’ inclination to adopt green banking and their subsequent usage behavior. This research will help to shape future studies in this particular field.
Identification and Functional Characterization of a Novel PRPS1 Variant in X‐Linked Nonsyndromic Hearing Loss: Insights From Zebrafish and Cellular Models
Authors: Wan Yining , Li Jinqiu , Guo Yingyuan , Guo Fang , Zhao Ying , Li Yue , Yang Xia , Chen Huidan , Xie Shimin , Wang Mingyong , Guan Guofang , Zhu Yilong , Li Xiao
Published: February 2025

Purpose: The study was aimed at identifying the pathogenic gene responsible for X‐linked nonsyndromic hearing loss (NSHL) in a five‐generation Chinese family and at elucidating the gene’s function both in vivo using a zebrafish model and in vitro using PRPS1 knockdown HEI‐OC1 cells.

Methods: Exome sequencing (ES) and Sanger sequencing were used to identify the pathogenic variants. A transgenic zebrafish model overexpressing the novel PRPS1 variant (c.494G>A: p.Cys165Tyr) was constructed, and PRPS1 was knocked down in HEI‐OC1 cells using siRNA to explore the underlying mechanisms. Hair cell development and behavior were assessed in zebrafish, and mitochondrial function and cell viability were analyzed in HEI‐OC1 cells.

Results: A novel missense variant (c.494G>A: p.Cys165Tyr) in the PRPS1 gene was identified as the pathogenic variant causing progressive X‐linked deafness‐1 (DFNX1). The variant led to hair cell death in zebrafish, with disrupted swimming behavior. In HEI‐OC1 cells, PRPS1 knockdown resulted in downregulation of the nicotinamide adenine dinucleotide (NAD+)/sirtuin 3 (SIRT3)/superoxide dismutase 2 (SOD2) pathway, increased reactive oxygen species (ROS) accumulation, mitochondrial dysfunction, and apoptosis, which were partially rescued by pretreatment with nicotinamide mononucleotide (NMN), a precursor of NAD+.

Conclusion: The study reports a novel PRPS1 variant contributing to the variant spectrum of PRPS1 and highlights the role of PRPS1 deficiency in increasing oxidative stress‐induced hair cell apoptosis via the NAD+/SIRT3/SOD2 pathway. These findings provide new insights into the molecular mechanisms of PRPS1‐related hearing loss and potential therapeutic targets.
Cryptocurrency Trend Prediction Through Hybrid Deep Transfer Learning
Authors: Jahanbin Kia , Chahooki Mohammad Ali Zare
Published: February 2025

The impact of sentiment analysis of comments on social networks such as X (Twitter) on the cryptocurrency market’s behavior has been proven. Also, traditional sentiment analysis and not considering the possible aspects of tweets can cause the deep model to be misleading in predicting the price trend of cryptocurrencies. In this research, a model using transfer learning and the combination of pretrained DistilBERT networks, BiGRU deep neural network, and attention layer is presented to analyze the sentiments based on the aspect of tweets and predict the price trend of eight cryptocurrencies. These tweets are the opinions of 70 cryptocurrency expert influencers. After preprocessing, these tweets are injected into the hybrid model of DistilBERT, BiGRU, and attention layer (HDBA) to extract the aspect and determine the polarity of each aspect. The output of the HDBA model is entered into the combined model of BiGRU and the attention layer (HBA) to predict the price trend of each cryptocurrency in intervals of 1–10 days. The output of the HBA model is the best time interval of the influence of the sentiments of tweets on the price trend of cryptocurrencies. The results show that the HDBA model has improved the performance of the aspect‐based sentiment analysis task by an average of 3% in the benchmark datasets. The results of the HBA model also show that this model has been able to predict the best time frame of the impact of sentiments on the behavior of the cryptocurrency market with an average accuracy of 68% and a precision of 73%.
Figure S4 from Expression Patterns of DLL3 across Neuroendocrine and Non-neuroendocrine Neoplasms Reveal Broad Opportunities for Therapeutic Targeting
Authors: Lozada John R. , Elliott Andrew , Evans Mark G. , Wacker James , Storey Kathleen M. , Egusa Emily A. , Zorko Nicholas A. , Kumar Akhilesh , Crymes Anthony , Heath Elisabeth I. , Carneiro Benedito A. , Soares Heloisa P. , Cichocki Frank , Miller Jeffrey S. , Lou Emil , Beltran Himisha , Antonarakis Emmanuel S. , Ryan Charles J. , Hwang Justin H.
Published: February 2025

Supplementary Figure S4: Genetic dependencies in neuroendocrine cancer cell lines. Scatterplot displaying gene depletion effects in NEN lines represented in DepMap. Data points represent the mean gene depletion effect of each gene target. Highlighted genes represent potential dependencies (gene effect < -0.5).
ВИКОРИСТАННЯ СУЧАСНИХ ІНСТРУМЕНТІВ ЦИФРОВОЇ ПАТОЛОГІЇ У ДІАГНОСТИЦІ ГЕПАТИТІВ
Authors: Ільченко В. В.
Published: February 2025

У роботі розглянуто питання використання сучасних доступних інструментів цифрової патології (перед усім програмного забезпечення з відкритим кодом), що можуть полегшити роботу лікаря-патологоанатома при морфологічній діагностиці гепатитів різного генезу та метаболічної жирової хвороби печінки (MAFLD). Головне завдання полягало в аналізі доступного програмного забезпечення, а також розробленні або доопрацюванні окремих його модулів для побудови системи управління зображеннями (СУЗ), перегляду цифрових сканів мікропрепаратів і спрощення оцінювання експресії імуногістохімічних (ІГХ) маркерів CD3, CD68, CD163, CD34 та α-SMA з кінцевою метою покращення вивчення ролі різних субпопуляцій печінкових макрофагів, синусоїдальних ендотеліальних клітин і фібробластів у прогресуванні захворювань печінки та розвитку фіброзу. За результатами проведеної роботи встановлено можливість розроблення програмного забезпечення для дослідження кількості та співвідношення різних популяцій клітин макрофагів, синусоїдальних ендотеліальних клітин, фібробластів і лімфоцитів у тканині печінки з використанням програмного забезпечення з відкритим кодом. Розроблене та вдосконалене автором програмне забезпечення дозволило створити зручний масив даних із цифрових сканованих зображень мікропрепаратів тканин печінки, з пришвидшеним і зручним доступом до відповідних даних. Модель потребує подальшого вдосконалення для покращення її чутливості в сенсі розпізнавання клітин конкретного типу.
НОВЕ БАЧЕННЯ ОСВІТНЬО-НАУКОВОЇ ПРОГРАМИ ЗА СПЕЦІАЛЬНІСТЮ 091 «БІОЛОГІЯ ТА БІОХІМІЯ»
Authors: Бабінцева Л. Ю. , Горовенко Н. Г. , Кирик Д. Л. , Соловйов С. О. , Суханова О. О. , Подольска С. В. , В’юницька Л. В.
Published: February 2025

Дослідження загальних властивостей і закономірностей розвитку живих організмів, вивчення видового різноманіття, а також хімічні процеси, що відбуваються всередині живих організмів, – ці знання, які надають науки біологія та біохімія, сприяють розв’язанню проблем людства: доступності достатньої кількості їжі, збереження здоров’я населення, збереження та покращення якості довкілля. Перебуваючи в постійному розвитку та вивчаючи ці важливі питання сучасні біологія та біохімія являють собою трансдисциплінарні галуззі знань, що потребують конкурентоспроможних, ініціативних, кваліфікованих, інтегрованих в європейський і світовий науково-освітній простір спеціалістів. Біологія та біохімія поряд із іншими природничими науками сприяють новим відкриттям, що істотно підсилюють рівень світової сучасної охорони здоров’я: від персональної медицини до біологічних основ психології людини, від розроблення нових біонічних матеріалів і пристроїв до клітинної інженерії. Життя розглядається на різних рівнях його організації – від молекули до біосфери, а узагальнення біохімії допомагають висвітлити еволюцію органічного світу та питання про виникнення життя на Землі.Отже, представлено новітнє бачення здобуття освіти майбутніх докторів філософії за спеціальністю 091 «Біологія та біохімія» галузі знань 09 «Біологія». Серед особливостей сучасної біології та біохімії виділяємо: комплексність та невизначеність умов, що передбачають застосування законів, теорій і методів природничих наук; вивчення взаємозв’язку біологічного та соціального розвитку людини; системну біомедицину; процедури і методи для вивчення діагностики та терапії захворювань і оцінювання здоров’я. Безумовно, ці особливості та всі напрями спеціальності, пов’язані із застосуванням інформаційних і цифрових технологій, штучного інтелекту.По завершенню навчання, здобувачі вищої освіти третього рівня мають оволодіти загальнонауковими компетентностями, здобути універсальні навики дослідника та мовні компетентності. Тематика курсу професійної підготовки розроблена з метою сприяння здатності інтегрувати знання та розв’язувати складні завдання в мультидисциплінарних і трансдисциплінарних контекстах.
Cardiomyocyte PRL2 Promotes Cardiac Hypertrophy via Directly Dephosphorylating AMPKα2
Authors: Han Xue , Shi Qiaojuan , Tu Yu , Zhang Jiajia , Wang Mengyang , Li Weiqi , Liu Yanan , Zheng Ruyi , Wei Jiajia , Ye Shiju , Zhang Yanmei , Ye Bozhi , Wang Yi , Ying Huazhong , Liang Guang
Published: February 2025

BACKGROUND:

Pathological cardiac hypertrophy can result in heart failure. Protein dephosphorylation plays a primary role in the mediation of various cellular processes in cardiomyocytes. Here, we investigated the effects of a protein tyrosine phosphatase, PRL2 (phosphatase of regenerative liver 2), on pathological cardiac hypertrophy.

METHODS:

The PRL2 knockout mice were subjected to angiotensin II infusion or transverse aortic constriction to induce myocardial hypertrophy and cardiac dysfunction. RNA-sequencing analysis was performed to explore the underlying mechanisms. Mass spectrometry and bio-layer interferometry assays were used to identify AMPKα2 (AMP-activated protein kinase α2) as an interacting protein of PRL2. Mutant plasmids of AMPKα2 were used to clarify how PRL2 interacts and dephosphorylates AMPKα2.

RESULTS:

A significant upregulation of PRL2 was observed in hypertrophic myocardium tissues in mice and patients with heart failure. PRL2 deficiency alleviated cardiac hypertrophy, fibrosis, and dysfunction in mice challenged with angiotensin II infusion or transverse aortic constriction. Transcriptomic and biochemical analyses showed that PRL2 knockout or silence maintained AMPK
T172
phosphorylation and subsequent mitochondrial integrity in angiotensin II-challenged heart tissues or cardiomyocytes. Mass spectrometry-based interactome assay indicated AMPKα2 subunit as the substrate of PRL2. Mechanistically, PRL2 binds to the C-terminal domain of AMPKα2 and then dephosphorylates AMPKα2
T172
via its active site C46. Adeno-associated virus 9-mediated deficiency of cardiomyocyte PRL2 also protected cardiac mitochondrial function and showed cardioprotective effects in angiotensin II-challenged mice, but these benefits were not observed in AMPKα2
−/−
mice.

CONCLUSIONS:

This study reveals that PRL2, as a novel AMPK-regulating phosphatase, promotes mitochondrial instability and hypertrophic injury in cardiomyocytes and provides PLR2 as a potential target for future drug development treating heart failure.
Regulation and Clinical Application of Exosomes in Venous Thrombosis
Authors: Shao Fei , He Ruchang , Jin Yang , Pang Yunfeng , Sun Ziqiang , Zhang Bin , Jin Song
Published: February 2025

Exosomes refer to a group of extracellular vesicles naturally released from mammalian cells with a diameter of 30–150 nm. Exosomes contain a variety of biologically active molecules, such as cytoplasmic proteins, chemokines, cytokines, and microRNA (miRNA). They are widely involved in intercellular communication and regulate the behavior of recipient cells. Venous thrombosis is a pathological change caused by vascular endothelial cell damage, hemodynamic changes, and the hypercoagulable state of blood. Exosomes from different cell sources are involved in the process of venous thrombosis. Exosomes can also be used as therapeutic carriers for tissue regeneration and drug delivery. Therefore, the study of exosomes is crucial for the formation, diagnosis, and treatment of venous thrombosis. In this review, we summarize the biological characteristics of exosomes and their mechanism of action in venous thrombosis. In addition, we also focused on its potential clinical applications, including as a diagnostic marker and therapeutic carrier for venous thrombosis.
Determination of the biological variation and reference change value of lipoprotein (a)
Authors: Antwi Kofi , Downie Paul , Mbagaya Wycliffe
Published: February 2025

Background

Understanding lipoprotein (a) [Lp(a)] measurement variability is essential in establishing its coronary heart disease (CHD) association, and optimizing assessment and management of atherosclerotic cardiovascular disease (ASCVD) risk. We established the components of biological variation (BV) and reference change value (RCV) of Lp(a) in a UK cohort.

Method

22 healthy individuals were recruited to the study. Blood samples were collected for six consecutive weeks and analysed in duplicate using the Lp(a) assay by Sentinel Diagnostics on the Beckman Coulter AU5800. Outlier, heterogeneity, normality, and trend analysis were performed, followed by CV-ANOVA to determine estimates of BV, adhering to the 14 BIVAC quality items. RCV was calculated based on estimated CVA and CVI.

Results

Four participants were excluded from the analysis as their mean Lp(a) levels fell below the functional sensitivity of the assay. Mean Lp(a) concentration ranged from 14 to 241 nmol/L. The overall estimate of CVI for all participants was 10.9% (95% CI of 9.1 – 13.0%). The RCV for Lp(a) was +31.6%/-24.0%.

Conclusion

Our study obtained a CVI estimate for Lp(a) that aligned consistently with recent studies adhering to the quality specifications outlined in the BIVAC checklist. The CVI estimate was significantly lower than Lp(a) estimates reported in studies up to 2003. The CVI estimate highlights the limitations of relying solely on a single Lp(a) measurement for prognosticating ASCVD risk and identifying candidates for novel Lp(a) therapies, particularly when the measured value is near clinical decision thresholds.
Rappresentare la Cultura Target: l’Italia nei manuali d’italiano in Cina
Authors: Cai Shijin , Gao Ru , Sanviti Ilaria
Published: February 2025

La presente ricerca esamina l’evoluzione delle rappresentazioni della cultura italiana all’interno dei manuali di italiano come lingua straniera, utilizzati nel contesto didattico cinese. Attraverso un’analisi diacronica di tre manuali pubblicati in differenti periodi storici (1972, 1991, 2022), emerge un evidente spostamento dell’enfasi dalla cultura cinese verso una maggiore centralità della cultura italiana. L’analisi mette in luce dinamiche specifiche nella rappresentazione delle varie dimensioni della cultura italiana: si osserva un graduale equilibrio nelle rappresentazioni delle differenti dimensioni culturali, con una resa esplicita delle pratiche culturali e una presenza in crescita, seppur ancora marginale, delle prospettive culturali. Inoltre, si rileva un bilanciamento quasi paritetico tra rappresentazioni esplicite e implicite. Infine, l’analisi evidenzia la complessa interazione tra obiettivi educativi, contesti socio-storici e rappresentazioni culturali nei manuali di lingua, sottolineando come la rappresentazione della cultura italiana in tali testi costituisca un elemento attivo e plasmante nel contesto dell’educazione linguistica.
Machine learning frameworks to accurately predict coke reactivity index
Authors: Adhab Ayat Hussein , Mahdi Morug Salih , Vaghela Krunal , Yadav Anupam , B Jayaprakash , Kundlas Mayank , Srivastava Ankur , Jagtap Jayant , Mansoor Aseel Salah , Radi Usama Kadem , Abd Nasr Saadoun , Sherzod Samim
Published: February 2025

Precisely forecasting coke reactivity index (CRI) plays a critical role in the metallurgical industry, as it enables optimization of coke quality, leading to cost-effective production and efficient resource utilization. In this research, several machine learning predictive models based on extra trees, decision tree, support vector machine, random forest, multilayer perceptron artificial neural network, K-nearest neighbors, convolutional neural network, ensemble learning, and adaptive boosting using a dataset gathered from a coke plant are developed to predict CRI. To minimize overfitting in each algorithm, K-fold cross-validation methodology is employed during the training phase. The efficacy of each algorithm is visually represented through graphical methods and quantitatively evaluated using performance metrics. The findings indicate that maximum fluidity and mean maximum reflectance (MMR) exhibit a direct correlation with CRI while being indirectly relevant to moisture content, ash content, sulfur content, basicity index, plastic layer thickness, and MMR. Among the various predictive models evaluated, the random forest model emerged as the most accurate tool, according to the performance metrics of R-squared, mean square error, and average absolute relative error (%), with numerical values of 0.958, 3.718, and 2.545%, respectively, for the total datapoints. The developed tool can be easily used to accurately estimate CRI without needing experimental or field data reliably.
All the Lonely People: An Integrated Review and Research Agenda on Work and Loneliness
Authors: McCarthy Julie M. , Erdogan Berrin , Bauer Talya N. , Kudret Selin , Campion Emily
Published: February 2025

Decades of studies spanning multiple disciplines have provided insight into the critical role of loneliness in work contexts. In spite of this extensive research, a comprehensive review of loneliness and work remains absent. To address this gap, we conducted a multidisciplinary review of relevant theory and research and identified 213 articles reporting on 233 empirical studies from management, organizational psychology, sociology, medicine, and other domains to uncover why people feel lonely, how different features of work can contribute to feelings of loneliness, and the implications of employee loneliness for organizational settings. This enabled a critical examination of the distinct conceptualizations and operationalizations of loneliness that have been advanced and the theories underpinning this scholarship. We developed a comprehensive conceptual model that integrates cognitive discrepancy theory, the affect theory of social exchange, and evolutionary theory. This model elucidates the core antecedents, mediators, outcomes, moderators, and interventions forming the nomological network of work related loneliness, including cross-level influences within teams and among leaders. Our review also identifies a number of promising areas for future inquiry to improve our understanding and measurement of loneliness, the process of experiencing and managing loneliness in the workplace, and potential interventions to reduce it. Finally, we provide tangible guidance for organizations and practitioners on how to address and mitigate employee loneliness. Ultimately, our review underscores the complex nature of loneliness and work and establishes a foundation for advancing both scholarly discourse and organizational practices in this critical domain.
Functionalized hydrogels promote the repair of large segmental bone defects by simultaneously regulating angiogenesis and osteogenesis
Authors: Liu Bangding , Tang Yongliang , Li Ni , Ren Bo
Published: February 2025

The treatment of large segmental bone defects has always been a difficult problem in orthopedic treatment, which is characterized by local microenvironment with impaired blood supply and absolute or relatively insufficient osteogenic ability. In these clinical scenarios, the bone repair process is often hindered, and the incidence of complications is increased. Therefore, obtaining a coordinated microenvironment of angiogenesis and osteogenesis will be an effective treatment strategy. In this study, we incorporated ophiopogon D (OPD) into a hydrogel matrix network with amino polyethylene glycol and sodium alginate oxide as raw materials to construct an injectable functional biomaterial for promoting angiogenesis and osteogenic differentiation. In vitro studies showed that the constructed hydrogel material had satisfactory injectability and self-healing properties, and could continuously release OPD locally, thus promoting the migration and angiogenesis of human umbilical vein endothelial cells in vitro, and promoting the osteogenic differentiation of bone marrow mesenchymal stem cells. After the functional hydrogel was implanted into the large segmental bone defect of the radius in a rabbit model, it could enhance the expression of local angiogenic and osteogenic protein, improve the osteogenic microenvironment, and thus accelerate bone repair. This study provides a new strategy and theoretical basis for the design of minimally invasive bone tissue engineering materials and the treatment of large segmental bone defects.