bluuebunny/crossref_metadata_2025 huggingface dataset:
Hubungan Faktor Kolestrol Terhadap Gula Darah Diabetes dengan Spline Kubik Terbobot
Authors: Ramdhani Zhazha Alifkhamulki , Islamiyati Anna , Raupong Raupong
Published: April 2020

Diabetes Mellitus (DM) is often recognized through an increase in a person's blood sugar level. Factors that can affect the increase in blood sugar levels of DM patients one of which is cholesterol. It usually contains the bookkeeping of several types of cholesterol, including LDL and total cholesterol. DM data are assumed to experience heterokedasticity so that in this study analyzed using regression of weighted cubic spline nonparametric. The estimation method used is weighted least square (WLS). This study aims to obtain a weighted cubic spline model on cholesterol based DM data. The selection of the best model can be seen based on the criteria for the value of generalized cross validation (GCV) minimum. Based on the analysis obtained weighted cubic spline models for cholesterol factors for blood sugar as follows:
Isolation of a lytic bacteriophage vB_EfaS_PHB08 and its endolysin lys08 against Enterococcus faecalis biofilm
Authors: Yang Dan , Chen Yibao , Sun Erchao , Hua Lin , Peng Zhong , Chen Huanchun , Wu Bin
Published: April 2020

Background: Enterococcus faecalis is an opportunistic pathogen can cause a variety of diseases, such as urinary tract infections and wound infections in human and animals. Recently, bacteriophages and their derivatives represent a good effect on fighting against bacterial infections. Methods: We isolated virulent bacteriophages of E. faecalis using the double-layer plate method. The bio-activities of the phage isolated were determined via one-step growth curve testing and bacterial killing assays. Illumina HiSeq sequencing was performed to determine the genetic characteristics and the lysins of the phage. Protein expression and antibiofilm assays were also performed to highlight the bio-activities of the phage lysins. Results: We isolated a virulent bacteriophage vB_EfaS_PHB08 (thereafter PHB08) from the sewage nearby hospital. PHB08 possessed a linear double-stranded DNA genome with 55,244 bp in length, which encoded 91 putative coding sequences (CDS). We found that PHB08 could inhibit the growth of host bacteria for 12 h. In vegetable models, PHB08 can reduce 1´105 Colony Forming Units (CFU) of E. faecalis per square centimeter at room temperature (25 °C) for 24 h. In addition, PHB08 and its endolysin can remove the biofilm formed by E. faecalis. Conclusions: A virulent phage and endolysin displayed a good effect on reducing and/or eradicating E. faecalis infection and biofilm.
Automatic Ventral Intermediate Nucleus Localization Based on Anterior Commissure and Posterior Commissure
Authors: Sarno Riyanarto , Sungkono Kelly Rossa , Rifqi Mohammad Ardika , Fahmi Achmad , Turchan Agus , Bajamal Abdul Hafid
Published: April 2020

The ventral intermediate nucleus (Vim) of the thalamus is a brain lesion target for decreasing tremors in Parkinson’s disease patients. Determination of the location of the Vim is challenging because magnetic resonance imaging (MRI) cannot detect it. Several Vim targeting methods have been proposed, such as Coordinate-based targeting and Guiot’s methods. However, these methods are manually implemented by doctors based on MRI data, so the accuracy of the targeting depends on their memory and foresight. This paper proposes a method to automate Vim localization using Coordinate-based targeting and Guiot’s method. Firstly, this paper determines the plane of the anterior commissure (AC) and the posterior commissure (PC) because to enforce medical images and determine the centre as the middle of AC-PC. Secondly, the coordinates are converted from millimetres to voxels in determining the Vim location. The converter is needed because Coordinate-based targeting and Guiot’s method measure the Vim location in millimetres while the three-dimensional images are measured in voxels. This paper also calculates similarity percentages and averages of error results to determine the accuracy and the robustness of automatic Coordinate-based targeting and Guiot’s. The experiments verify Coordinate-based targeting is higher accuracy and more robust than Guiot’s.
A novel method for psychotropic drugs education: An interventional study
Authors: Tabandeh Zahra , Zarshenas Ladan , Mehrabi Manoosh , Nekooeian Ali akbar , Sarani Ebrahim Moghimi
Published: April 2020

Background: Familiarity with and management of drugs side-effects are among nurses’ main educational needs with respect to pharmacological care in psychiatry departments. This study aimed to determine the effects of psychoactive drugs education through mobile phone and group discussion on nursing students’ attitude, satisfaction, and learning.Methods: This interventional study was done in Shiraz University of Medical Sciences in 2018. The participants included 40 nursing students passing the mental health apprenticeship in their 6 th educational semester. The 32 students with inclusion criteria were randomly divided into two groups each containing 16 subjects. The first group underwent the educational intervention through group discussion within the first two weeks of apprenticeship. The second group, on the other hand, received the educational intervention through mobile phones over the second two weeks of the course. The students’ learning, attitude, and satisfaction were assessed before and two weeks after the intervention and were compared two groups. After all, the data were entered into the SPSS statistical software, version 16 and were analyzed using descriptive and inferential (paired and independent t-test) statistics. P<0.05 was considered to be statistically significant.Results: The results showed a significant difference in the two groups’ rate of learning before and after the intervention (p=0.00). However, no significant difference was found between the two groups in this regard (p=0.158). The results also revealed a significant difference in the two groups’ satisfaction with the instruction method before and after the intervention. A significant difference was also observed between the two groups in this regard (p=0.043). Finally, the results indicated that the students in the mobile phone group developed a significantly more positive attitude after the intervention compared to baseline (p=0.038).Conclusions: The study results demonstrated that mobile teaching methods could be effective in students’ learning, satisfaction, and attitude. Thus, further studies are recommended to be conducted on other medical and nursing apprenticeships, so that such methods can be used in clinical education in case of obtaining similar results.
Selection and implementation of SNP markers for parentage analysis in a Chinese crossbred cattle population
Authors: Hu Lirong , Li Dong , Chu Qin , Wang Yachun , Zhou Lei , Yu Ying , Zhang Yuan , Zhang Shengli , Usman Tahir , Xie Zhenquan , Hou Shiyu , Liu Lin , Shi Wanhai
Published: April 2020

Combining direct sequencing method in polymerase chain reaction (PCR) products of deoxyribonucleic acid (DNA) pooling and matrix-assisted laser desorption/ionisation time of flight mass spectrometry (MALDI-TOF MS) genotyping method in individuals, a panel consisting of 50 highly informative single nucleotide polymorphisms (SNPs) for parentage analysis was developed in a crossbred Chinese cattle population. The average minor allele frequency (MAF) was 0.43 and the cumulative exclusion probability for single-parent and both-parent inference met 0.99797 and 0.999999, respectively. The maker-set was then used for parentage verification in a group of 81 trios with the likelihood-based parentage-assignment program of Cervus software. Compared with on-farm records, the results showed that this 50-SNP system could provide sufficient and reliable information for parentage testing with the parental mistakes for mother-offspring and sire-offspring being 8.6% and 18.5%, respectively. Knowledge of these results, we provided one low-cost and efficient method of SNP assays for running paternity testing in crossbred cattle population of Simmental and Holstein in China.
Associations of vascular risk factors, APOE ɛ4 allele, and TOMM40 G allele with cognitive function in Chinese older adults: a community-based study
Authors: Gui Wenjun , Qiu Chengxuan , Li Juan
Published: April 2020

Background : The associations of vascular risk factors (VRFs) , apolipoprotein E (APOE) ɛ4 allele, and translocase of outer mitochondrial membrane 40 (TOMM40) G allele with cognitive function have been investigated mostly in western societies. In the present study, we sought to examine the associations of VRFs, APOE ε4 allele, and TMM40 G allele (rs2075650) with global cognitive function among Chinese older adults, with a focus on potential interactions between VRFs and the susceptibility genes. Methods : This is a cross-sectional study that included 422 participants (mean age 69.2 years, 54.3% female) in the China Longitudinal Ageing Study , who were free of dementia. Data were collected through interviews, clinical examinations, and laboratory tests. The clustering of multiple VRFs was scored by counting the number of VRFs potentially related to cognitive function. Global cognitive function was assessed with the Mini-Mental State Examination (MMSE). Data were analyzed with multiple general linear regression models. Results : Physical inactivity and diabetes were independently associated with performance lower MMSE score ( p <0.05). Moreover, physical inactivity interacted with APOE ε4 and TOMM40 G allele (rs2075650), and diabetes interacted with TOM40 G allele to affect cognitive function, such that having physical inactivity in combination with either APOE ε4 allele or TOMM40 G allele, or having diabetes and TOMM40 G allele, compared to having neither, was significantly associated with markedly lower MMSE scores ( p <0.05). Finally, when four modifiable VRFs (i.e., current smoking, physical inactivity, high LDL-C, and diabetes) were aggregated, an increasing number of having these factors was associated with a decreasing MMSE score in a dose-response manner ( p for trend<0.05). Conclusion : Some VRFs (e.g., physical inactivity and diabetes), when concurrently occurring with APOE ε4 or TOMM40 G allele, are associated with substantially poor performance in global cognitive function among the Chinese elderly .
Short-term efficacy comparison between helical tomotherapy and intensity-modulated radiotherapy in patients with locally advanced nasopharyngeal carcinoma
Authors: Cui Zhen , Liu Jia , Sun Qiaoyu , Wang Chaoge , Fang Meifang , He Zelai , Li Duojie , Jiang Hao
Published: April 2020

Background: To evaluate short-term safety and efficacy of helical tomotherapy (HT) versus intensity-modulated radiotherapy (IMRT) in patients with nasopharyngeal carcinoma (NPC).Methods: Retrospective analysis of locally advanced nasopharyngeal carcinoma treated with radiotherapy and concurrent platinum based neoadjuvant chemotherapy (cisplatin 80 mg/m2 every 3 weeks for 1 cycle) in our hospital from February 2017 to October 2019, including 70 patients in HT group and 70 in IMRT group. The target area of ​​the tumor was delineated by magnetic resonance (MRI) imaging. The prescription doses delivered to the gross tumor volume (pGTVnx) and positive lymph nodes (pGTVnd), the high risk planning target volume (PTV1), and the low risk planning target volume (PTV2), were 69.96 Gy, 66-70 Gy, 60 Gy and 50-54 Gy, in 33 fractions, respectively. Acute reactions were evaluated according to the RTOG/EORTC criteria, whereas the therapeutic efficacy was assessed according to RECTST version 1.1 criteria in a 3-months period.Results: The CI of PGTVnx, PGTVnd, PTV1 and PTV2, and HI of PGTVnx, PTV1 and PTV2 in HT group was significantly better than those in IMRT group. The OAR Dmax and Dmean in HT group were better than those in IMRT group with a significant difference (all p <0.05). Patients in the HT group were significantly better than those in the IMRT group in the protection of acute parotid gland injury and hearing damage (p <0.05), but not other acute adverse reaction. No significant difference was found on the short-term efficacy illustrated by ORR between HT group and IMRT group (x2 = 0.119; p = 0.730).Conclusions: Compared with IMRT, HT has better radiophysical-related dosimetric advantages in radiotherapy for locally advanced nasopharyngeal carcinoma. Despite similar on short-term effects, HT has lower incidence of adverse reactions than IMRT.
Prognostic Factors for Outcome and Survival after Laparotomy in Patients with Pancreatic Trauma: One Single-center Experience.
Authors: Yang Chao , Liu Baochen , Wu Cuili , Wang Yongle , Wang Kai , Li Weiqin , ding weiwei
Published: April 2020

Background: Pancreatic trauma results in significant morbidity and mortality. Few studies have investigated the postoperative prognostic factors in patients with pancreatic trauma after surgery. Methods: A retrospective study was conducted on 152 consecutive patients with pancreatic trauma who underwent surgery in Jinling Hospital, a national referral trauma center in China, from January 2012 to December 2019. Univariate and binary logistic regression analyses were performed to identify the perioperative clinical parameters that may affect the morbidity of the patients. Results: A total of 184 patients with pancreatic trauma were admitted during the study period, and 32 patients with nonoperative management were excluded. The remaining 152 patients underwent laparotomy due to pancreatic trauma. Sixty-four patients were referred from other centers due to postoperative complications. Abdominal bleeding caused by pancreatic leakage ( 10 of all deaths) and severe intra-abdominal infection (12 of all deaths) were the major causes of mortality. Twenty-eight (77.8%) of the 36 patients who had damage control laparotomy survived. Univariate analysis showed that age, hemodynamic status, and injury severe score (ISS) as well as postoperative serum levels of C-reactive protein (CRP), procalcitonin, albumin and creatinine and the volume of intraoperative blood transfusion had significant effects on the mortality ( P <0.05). Binary logistic regression analysis showed that the independent risk factors for prognosis after pancreatic trauma surgery were age ( P =0.012), preoperative hemodynamic instability ( P =0.018), postoperative CPR ≥154 mg/L ( P =0.016), and postoperative serum creatinine ≥177 μmol/L ( P =0.017). The 30-day mortality rate was 15.8%. Conclusions: In this single-center retrospective study, we first demonstrated that severe intra-abdominal infection and bleeding were the major factors affecting the prognosis of patients with pancreatic trauma after surgery. Preoperative hemodynamic instability, severe postoperative inflammation (CRP ≥154 mg/L) and acute renal failure (creatinine ≥177 μmol/L) were associated with a significant risk of mortality.
Angiotensin-Converting Enzyme inhibitors (ACE inhibitors) and Angiotensin II Receptor Blockers (ARBs) role in SARS-CoV-2 infection: A Rapid Systematic Review
Authors: Junior Haliton Alves de Oliveira , Matuoka Jessica Yumi , Parreira Patrícia do Carmo Silva , Brito Gabriela Vilela de , Marra Lays Pires , Medeiros Flávia Cordeiro de , Junior Álvaro Avezum
Published: April 2020

No medications specific treatments are known to be effective for COVID-19 until now. Several drug therapies are being used to optimize supportive care to relieve symptoms. Some observational and essentially theoretical studies have shared opposite opinions regarding the use of ACE inhibitors and ARBs in SARS-CoV-2 infected patients. Therefore, the aim of this review is to evaluate the relationship between ACE inhibitors and ARBs use and clinical effects in COVID-19 patients to guide clinicians for their medical early decision. Electronic searches were conducted on Embase, Medline via PubMed and ClinicalTrials.gov. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement was followed and adapted the research as a rapid review. Due to the emergency of the COVID-19 pandemic, any research in English, Portuguese or Spanish that discuss the mechanism of action, in vitro studies and those that draw conclusions based on observational or experimental studies were included. No studies were excluded based on the participant’s clinical or demographical characteristics. The risk of bias was assessed by one reviewer and checked by a second reviewer, using the Joanna Briggs Institute Checklist for Case Series. Any other mechanistic, theoretical or in vitro studies were evaluated as high risk of bias for clinical. Out of 64 studies retrieved, 17 were included in the review. Three studies suggest that both medications may increase the risk of worsening COVID-19, while three suggest they could be beneficial. Currently, there are seven ongoing trials on ARBs and ACE inhibitors. The available evidence does not allow us to draw definite conclusions on either harm or benefit of these medications in the presence of COVID-19. Discontinuing the therapy may be hasty and more robust evidence-based research is needed.
Effects of drought stress and superabsorbent polymer on morpho-physiological and biochemical traits of Caper (Capparis spinosa L.)
Authors: Bagherifard Aminallah , Hamidoghli Yousef , Biglouei Mohammad Hasan , Ghaedi Mehrorang
Published: April 2020

Capparis spinosa, commonly known as caper bush, is native to certain hostile growing conditions including sandy or gravelly soils, rocky hillsides, cliffs, stone walls and rock crevices in Mediterranean coastal regions. Caper plant is used for the prevention of soil erosion in sloppy areas. Synthetic superabsorbent polymer was developed as a soil conditioner to heighten plant establishment and growth in drought-prone growing area. During growing seasons of 2016-2017, the effects of soil amendment with the superabsorbent Polymer A200 in four levels (S1= 0, S2= 75, S3= 150 and S4= 225 g) were investigated for each caper plant, considering three levels of irrigation (I1=0, I2= One irrigation per month and I3= one irrigation every two months) on the physical properties of the soil as well as their physiological parameters (chlorophyll a, b and total chlorophyll, carotenoid, Tss, electrolyte leakage) and plant height, yield per hectare, WUE, Soil moister, RWC and leaf area of an established caper plant under drying conditions. Analyses of variance showed that the interaction effects of treatments were significant (p<0.01) in all the studied traits. The results showed that water stress significantly decreased the height of a plant, yield per hectare, WUE, Soil moister, RWC, leaf area, total Chlorophylla, Carotenoid and electrolyte leakage, whereas the application of superabsorbent polymer compensated for the negative effect of drought stress, especially in high rates of polymer application (150 g), where the maximum effect was attained for all the studied traits. These findings strongly suggested that the irrigation intervals of caper can lead to an increase in the application of the superabsorbent polymer.
Can silicon (Si) influence growth, physiology and postharvest quality of lettuce?
Authors: Neto Hozano de Souza Lemos , Guimarães Marcelo de Almeida , Sampaio Italo Marlone Gomes , Rabelo Janiquelle da Silva , Viana Caris dos Santos , Mesquita Rosilene Oliveira
Published: April 2020

Although it is not considered an essential element for plants, silicon (Si) provides benefits for several species, especially grasses, such as increase in yield and resistance to pests and diseases, reducing the effects of salt and water stress, among others. The aim of this study was to evaluate the effect of silicon on the performance of lettuce in hydroponic system. The experiment was carried out in a completely randomized design, with five doses of silicon (0, 2, 4, 6, 8 mM) in the nutrient solution. Shoot fresh and dry mass, gas exchanges, photosynthetic pigments and post-harvest were evaluated. It was observed that from the dose of 2 mM, there was a reduction in most variables. The dose of 0.4 mM [(-0.572)/(2*-0.7055)] provided a greater increase in shoot fresh mass. The highest photosynthetic rate was at the dose of 3.19 mM. Soluble solids, titratable acidity and pH were higher at the 4 mM dose. Silicon provides better lettuce production, with a dose of 0.4 mM allowing a greater shoot fresh mass, being the most indicated for lettuce cultivation in hydroponic system.
Reaction of Avena spp. to different concentration levels of Meloidogyne javanica and M. incognita inoculum
Authors: Lemes Cláudia Fernanda Carraro- , Deuner Carolina Cardoso , Basso Simone Meredith Scheffer- , Mazzetti Valéria Cecília Ghissi , Novakowiski Jaqueline Huzar
Published: April 2020

The objective of this study was to evaluate the resistance reaction of Avena spp. after inoculation of different concentrations of eggs and juveniles of M. javanica and M. incognita. Ten oat genotypes (Avena sativa: UPFPS Farroupilha, UPFA Ouro, IPR Afrodite, AF1345 Ucraniana; A. strigosa: Agro Quaraí, Agro Esteio, Embrapa 139, Iapar 61 Ibiporã, UPFA 21 Moreninha, AF 12202) were evaluated in bioassays for resistance against the root-knot nematodes, Meloidogyne javanica and M. incognita. Susceptible (Solanum lycopersicum and Glycine max) and resistant (Crotalaria spectabilis) species were used as control treatments. Depending on the inoculum level, the oats showed a different response to nematodes. All genotypes of oats were resistant to M. javanica when a high inoculum level (5,000 eggs and J2 per plant) was used but under low inoculum level (1,500 eggs and J2 per plant), AF 12202, Iapar 61 Ibiporã, Agro Esteio and Agro Quaraí were susceptible. All genotypes of oats were resistant to the inoculation of 2,900 eggs and J2 of M. incognita, except for ‘Iapar 61’ that showed susceptibility in this concentration. At lower inoculum level (1,500 eggs and J2) Agro Quaraí, Agro Esteio and Iapar 61 Ibiporã were susceptible. The reaction of oats to M. javanica and M. incognita depends on the inoculum level. The resistance reaction at low inoculum density of A. sativa ‘AF 1345 Ucraniana’ and ‘IPR Afrodite’ allows its use in breeding programs in oats and suggests the possibility of management tool in areas infested with both root-knot nematode species.
Synthesis and Theoretical Study of a Series of 3,5-disubstitutes Pyrazoles
Authors: Enes Karine Braga , Branco Ana Clara Alves , Lima Maria Eduarda Toledo , Mateus Marcella Fernandes Mano , Guimaráes Luciana , Nascimento Clebio Soares , Couri Mara Rubia Costa
Published: April 2020

In this work, we proposed the synthesis of a series of pyrazoles derivatives with different
substituents on the aromatic rings. We aim to evaluate their influence on the reactivity of the compounds
in reactions of α,β-unsaturated chalcones and sulfonyl hydrazide catalyzed by iodine. In order
to explain their high and low yields, or the impossibility of obtaining some compounds by applied synthetic
methodology, Density Functional Theory (DFT) calculations were performed. The reaction
Gibbs free energy (ΔG) as well as the energy gap of the HOMO-LUMO frontier orbitals (ΔE) of some
selected reactants could explain qualitatively the experimental observations in terms of synthesis yield.
In this way, we believe that the chemical nature of aromatic ring substituents is relevant for the reactivity
of the starting materials as well as the formation of the desired products.
Lemon Juice as a Biocatalyst Under Ultrasound Irradiation: Synthesis and Pharmacological Evaluation of 2-amino 1,3,4-thiadiazoles
Authors: Prasad Malavattu G. , Lakshmi Chapala V. , Katari Naresh K. , Pal Manojit
Published: April 2020

Background:

The 2-amino 1,3,4-thiadiazole framework has attracted considerable interest because of its
prevalence in compounds possessing a wide range of pharmacological properties including anticancer/antitumor
activities. Though a number of methods have been reported for the synthesis of this class of compounds, some of
them are not straightforward, inexpensive and environmentally friendly.

Objective:

To synthesize 2-amino-1,3,4-thiadiazole derivatives that could act as potential anticancer agents.

Methods:

The use of lemon juice as an inexpensive and readily available biocatalyst was explored in the synthesis
of 2-amino 1,3,4-thiadiazole derivatives. Accordingly, a convenient method has been developed for the rapid synthesis
of this class of compounds under a mild and non-hazardous reaction condition in good yields. The methodology
involved the reaction of various acid hydrazides with TMSNCS in the presence of lemon juice in PEG-400 at
room temperature (25-30ºC) under ultrasound irradiation. These compounds were assessed for their cytotoxic properties
against two different metastatic breast cancer cell lines e.g., MDAMB-231 and MCF-7 and subsequently
against SIRT1.

Results:

The 2-amino 1,3,4-thiadiazole derivatives 3a, 3i, 3j and 3l showed promising growth inhibition of MDAMB-
231 and MCF-7 cell lines and SIRT1 inhibition in vitro. Indeed, 3i was found to be a potent inhibitor of SIRT1.

Conclusion:

An ultrasound-assisted method facilitated by lemon juice has been developed to synthesize 2-amino-
1,3,4-thiadiazole derivatives that could act as potential anticancer agents.
3 (2) Factorial Design Assisted Crushed Puffed Rice-HPMC-Chitosan based Hydrodynamically Balanced System of Metoprolol Succinate
Authors: Soni Shashank , Ram Veerma , Verma Anurag
Published: April 2020

Introduction:

Hydrodynamically balanced system (HBS) possesses prolonged and continuous
delivery of the drug to the gastrointestinal tract which improves the rate and extent of medications
that have a narrow absorption window. The objective of this work was to develop a Hydrodynamically
Balanced System (HBS) of Metoprolol Succinate (MS) as a model drug for sustained stomach specific
delivery.

Materials and Methods:

Experimental batches were designed according to 3(2) Taguchi factorial design. A total of 9
batches were prepared for batch size 100 capsules each. Formulations were prepared by physically
blending MS with polymers followed by encapsulation into hard gelatin capsule shell of size 0. Polymers
used were Low Molecular Weight Chitosan (LMWCH), Crushed Puffed Rice (CPR), and Hydroxypropyl
Methylcellulose K15 M (HPMC K15M). Two factors used were buoyancy time (Y1) and
time taken for 60% drug release (T60%; Y2).

Results:

The drug excipient interaction studies were performed by the thermal analysis method which
depicts that no drug excipient interaction occurs. In vitro buoyancy studies and drug release studies revealed
the efficacy of HBS to remain gastro retentive for a prolonged period and concurrently sustained
the release of MS in highly acidic medium. All formulations followed zero-order kinetics.

Conclusion:

Developed HBS of MS with hydrogel-forming polymers could be an ideal delivery system
for sustained stomach specific delivery and would be useful for the cardiac patients where the prolonged
therapeutic action is required.
SVM Ensemble-based Noise Detection Method for Image Denoising
Authors: Jia Xiaofen , Wang Chen , Guo Yongcun , Zhao Baiting , Huang Yourui
Published: April 2020

Background:

To preserve sharp edges and image details while removing noise, this paper
presents a denoising method based on Support Vector Machine (SVM) ensemble for detecting
noise.

Methods:

The proposed method ISVM can be divided into two stages: noise detection and noise
recovery. In the first stage, local binary features and weighted difference features are extracted as
input features vector of ISVM, and multiple sub-SVM classifiers are integrated to form the noise
classification model of ISVM by iteratively updating the sample weight. The pixels are divided into
noise points and signal points. In the noise recovery stage, according to the classification results of
the previous stage, only the gray value of the noise point is replaced, and the replacement value is
the weighted mean value with the reciprocal of the quadratic square of the distance as the weight.

Results:

Finally, the replacement value at the noise point and the original pixel value of the signal
point are reconstructed to get the denoised image.

Conclusion:

The experiments demonstrate that ISVM can achieve a noise detection rate of up to
99.68%. ISVM is highly effective in the denoising task, produces a visually pleasing denoised image
with clear edge information, and offers remarkable improvement compared to that of the BPDF
and DAMF.
Artificial Intelligence–Assisted System in Postoperative Follow-up of Orthopedic Patients: Exploratory Quantitative and Qualitative Study
Authors: Bian Yanyan , Xiang Yongbo , Tong Bingdu , Feng Bin , Weng Xisheng
Published: April 2020

Background

Patient follow-up is an essential part of hospital ward management. With the development of deep learning algorithms, individual follow-up assignments might be completed by artificial intelligence (AI). We developed an AI-assisted follow-up conversational agent that can simulate the human voice and select an appropriate follow-up time for quantitative, automatic, and personalized patient follow-up. Patient feedback and voice information could be collected and converted into text data automatically.

Objective

The primary objective of this study was to compare the cost-effectiveness of AI-assisted follow-up to manual follow-up of patients after surgery. The secondary objective was to compare the feedback from AI-assisted follow-up to feedback from manual follow-up.

Methods

The AI-assisted follow-up system was adopted in the Orthopedic Department of Peking Union Medical College Hospital in April 2019. A total of 270 patients were followed up through this system. Prior to that, 2656 patients were followed up by phone calls manually. Patient characteristics, telephone connection rate, follow-up rate, feedback collection rate, time spent, and feedback composition were compared between the two groups of patients.

Results

There was no statistically significant difference in age, gender, or disease between the two groups. There was no significant difference in telephone connection rate (manual: 2478/2656, 93.3%; AI-assisted: 249/270, 92.2%; P=.50) or successful follow-up rate (manual: 2301/2478, 92.9%; AI-assisted: 231/249, 92.8%; P=.96) between the two groups. The time spent on 100 patients in the manual follow-up group was about 9.3 hours. In contrast, the time spent on the AI-assisted follow-up was close to 0 hours. The feedback rate in the AI-assisted follow-up group was higher than that in the manual follow-up group (manual: 68/2656, 2.5%; AI-assisted: 28/270, 10.3%; P<.001). The composition of feedback was different in the two groups. Feedback from the AI-assisted follow-up group mainly included nursing, health education, and hospital environment content, while feedback from the manual follow-up group mostly included medical consultation content.

Conclusions

The effectiveness of AI-assisted follow-up was not inferior to that of manual follow-up. Human resource costs are saved by AI. AI can help obtain comprehensive feedback from patients, although its depth and pertinence of communication need to be improved.
Parent Perspectives on Family-Centered Pediatric Electronic Consultations: Qualitative Study (Preprint)
Authors: Verma Rhea , Krishnamurti Tamar , Ray Kristin N
Published: April 2020

BACKGROUND

Electronic consultations, which use store-and-forward transfer of clinical information between a primary care physician and a specialist, improve access to specialty care. Adoption of electronic consultations is beginning in pediatric health care systems, but little is known about parent perspectives, informational needs, and preferences for interaction with this new model of care.

OBJECTIVE

This study aimed to examine parent perspectives about electronic consultations, including perceived benefits and risks, anticipated informational needs, and preferences for parent engagement with electronic consultations.

METHODS

We recruited caregivers of pediatric patients (aged 0-21 years) attending visits at an academic primary care center. Caregivers were eligible if their child had ever been referred for in-person specialty care. Caregivers participated in a semistructured interview about electronic consultations, including general perspectives, desired information, and preferences for parental engagement. Interviews were transcribed and qualitatively analyzed to identify parent perspectives on electronic consultations in general, information parents would like to receive about electronic consultations, and perspectives on opportunities to enhance parent engagement with electronic consultations.

RESULTS

Interviewees (n=20) anticipated that electronic consultations would reduce the time burden of specialty care on families and that these had the potential to improve the integrity and availability of clinical information, but interviewees also expressed concern about data confidentiality. The most detailed information desired by interviewees about electronic consultations related to data security, including data confidentiality, availability, and integrity. Interviewees expressed concern that electronic consultations could exclude parents from their child’s health care decisions. Interviewees saw value in the potential ability to track the consultation status or to participate in the consultation dialogue, but they were more ambivalent about the idea of read-only access to consultation documentation.

CONCLUSIONS

Parents identified the potential risks and benefits of pediatric electronic consultations, with implications for communication with families about electronic consultations and for incorporation of features to enhance parent engagement.
The acceptability and feasibility of an online pathway for depression treatment via decision support: a cross-sectional survey. (Preprint)
Authors: Barr Paul J , Dannenberg Michelle D , Alam Shama S , Fortuna Karen L , Nguyen Theresa , Bruce Martha L
Published: April 2020

BACKGROUND

Individuals often turn to the internet seeking answers to their mental health problems. In 2014, Mental Health America (MHA) began the online program MHA Screening, including the PHQ-9, and since then has collected data from nearly 2.5 million people. Among those who complete a depression screening online, 83% report moderate to severe depression. Despite a range of evidence-based treatments for depression, 60% of these individuals do not seek care. A lack of both knowledge of and access to treatment are major barriers to help-seeking. Decision aids (DAs) are tools that can increase treatment knowledge, yet it is unclear if individuals with depression symptoms would use such a tool online.

OBJECTIVE

The objective of this project was to determine the views of individuals with depression toward an online DA for depression, and to determine the characteristics those most likely to review a DA and are willing to seek care online.

METHODS

MHA offers web-based depression screening using the Patient Health Questionnaire (PHQ-9). For this pilot, MHA made a link to a depression DA available to all individuals completing PHQ-9 screening from October – November 2017. The DA consisted of information on frequently asked questions pertaining to three treatment approaches: watchful waiting, talk therapy and antidepressants. Respondents viewing the DA could complete a short survey assessing the perceived helpfulness of the DA, and whether they would be “willing to consult a doctor online” about symptoms. Descriptive statistics were calculated, while a multiple logistic regression model identified characteristics associated with viewing the DA.

RESULTS

Of 74,936 PHQ-9 screens completed, 599 (8%) proceeded to review the depression DA; 92% of these respondents screened positive for moderate to severe depression and 86% had never sought prior treatment. Of the 599, 527 (88%) completed the DA survey: 46% found the DA to be helpful, 45% were unsure, while only 8% said the DA was not helpful. Higher levels of depression severity, female sex and older age were associated with increased likelihood of viewing the DA, while higher income levels and Black/African Americans were less likely to view the DA. A majority of respondents (72%) stated they would be willing to discuss their symptoms with a doctor online.

CONCLUSIONS

Screening for depression and providing DA outside of traditional settings is viewed positively and holds significant potential for those seeking care online. This knowledge is timely given the rising interest in the use online therapies, and the detrimental impact on psychological health of social isolation measures in response to the Coronavirus pandemic. Future work will determine the best placement of such decision support tools to maximize DA access, and assess the potential for an online pathway to treatment facilitated by screening and decision support.
Digital Health Management During and Beyond the COVID-19 Pandemic: Opportunities, Barriers, and Recommendations (Preprint)
Authors: Inkster Becky , O’Brien Ross , Selby Emma , Joshi Smriti , Subramanian Vinod , Kadaba Madhura , Schroeder Knut , Godson Suzi , Comley Kerstyn , Vollmer Sebastian J , Mateen Bilal A
Published: April 2020

UNSTRUCTURED

During the coronavirus disease (COVID-19) crisis, digital technologies have become a major route for accessing remote care. Therefore, the need to ensure that these tools are safe and effective has never been greater. We raise five calls to action to ensure the safety, availability, and long-term sustainability of these technologies: (1) due diligence: remove harmful health apps from app stores; (2) data insights: use relevant health data insights from high-quality digital tools to inform the greater response to COVID-19; (3) freely available resources: make high-quality digital health tools available without charge, where possible, and for as long as possible, especially to those who are most vulnerable; (4) digital transitioning: transform conventional offline mental health services to make them digitally available; and (5) population self-management: encourage governments and insurers to work with developers to look at how digital health management could be subsidized or funded. We believe this should be carried out at the population level, rather than at a prescription level.
SOFT ROBOT POSITIONING USING ARTIFICIAL NEURAL NETWORK
Authors: Kovandžić Marko , Nikolić Vlastimir , Simonović Miloš , Ćirić Ivan , Al-Noori Abdulathim
Published: April 2020

The experiment investigated the performance of an artificial neural network in solving the inverse kinematic problem of a soft robot. For this purpose, a simple soft robot was designed of building blocks, stringed on three rubber hoses, and an actuating system, to provide the hydraulic pressure. An axial extending of a hose, while the others are in the relaxed state, results in bending of the robot. The network was employed, as a black box, to approximate the behavior of the system. In accordance with the purpose, the input consisted of the desired spatial coordinates and the output of the step motor angular displacements. The network was trained and tested using records collected at 200 randomly chosen robot positions. The relative testing error of positioning, about 5%, confirmed a predictable robot behavior. The solution proposed is competitive in terms of simplicity, safety and price of realization. The experiment provided basics for the future research of the design of modular soft robots.
DETECTION OF TEXTURE-LESS OBJECTS BY LINE-BASED APPROACH
Authors: Cvetković Stevica , Grujić Nemanja , Ilić Slobodan , Stančić Goran
Published: April 2020

This paper proposes a method for tackling the problem of scalable object instance detection in the presence of clutter and occlusions. It gathers together advantages in respect of the state-of-the-art object detection approaches, being at the same time able to scale favorably with the number of models, computationally efficient and suited to texture-less objects as well. The proposed method has the following advantages: a) generality – it works for both texture-less and textured objects, b) scalability – it scales sub-linearly with the number of objects stored in the object database, and c) computational efficiency – it runs in near real-time. In contrast to the traditional affine-invariant detectors/descriptors which are local and not discriminative for texture-less objects, our method is based on line segments around which it computes semi-global descriptor by encoding gradient information in scale and rotation invariant manner. It relies on both texture and shape information and is, therefore, suited for both textured and texture-less objects. The descriptor is integrated into efficient object detection procedure which exploits the fact that the line segment determines scale, orientation and position of an object, by its two endpoints. This is used to construct several effective techniques for object hypotheses generation, scoring and multiple object reasoning; which are integrated in the proposed object detection procedure. Thanks to its ability to detect objects even if only one correct line match is found, our method allows detection of the objects under heavy clutter and occlusions. Extensive evaluation on several public benchmark datasets for texture-less and textured object detection, demonstrates its scalability and high effectiveness.
HYDROSTATIC SYSTEMS FOR ENERGY RECUPERATION IN EARTHMOVING MACHINES
Authors: Jovanović Vesna , Janošević Dragoslav , Ćirić Ivan , Pavlović Jovan
Published: April 2020

The first part of the paper contains the results of a study into the change in the energy parameters of earthmoving machines during manipulation tasks. The results of the research show that during certain operations of manipulation tasks, in the stop phase, the required energy of the machines has negative values. Modern earthmoving machines have hydrostatic drive systems that accumulate potential negative energy by recuperation and, if necessary, return it to the drive system of the machine for use in other operations of a manipulation task. In the second part of the paper, the analysis of the concepts of hydrostatic drive systems of earthmoving machines that enable energy recuperation is performed in detail.
ISLAMISASI ILMU PENGETAHUAN (Upaya “Dehegemoni” Ilmu Pengetahuan Barat)
Authors: Haris Abdul
Published: April 2020

ISLAMISASI ILMU PENGETAHUAN(Upaya “Dehegemoni” IlmuPengetahuan Barat)Abdul Haris *)*)FAI UMMABSTRACTThe issue of Islamization of knowledge is actually a problem that is long enoughdiscussion of the 80s when Ismail Raji al-Faruqi and his colleagues put forwardthe idea to rebuild the architecture of knowledge based on Islamic principles, evenat 70 years old Syed Muhammad Naguib al-Attas was also initiated this.However, discussion of science Islamization problem lately started to bloomagain in Indonesia, especially after changing a few IAIN be UIN. Ismal Raji al-Faruqi and his colleagues that includes understanding, background presence, anddevelopment principles.PendahuluanPersoalan islamisasi ilmupengetahuan sebenarnya merupakanpersoalan yang sudah cukup lamadiperbincangkan yakni pada tahun 80-an ketika Ismail Raji al-Faruqi dankawan-kawan mengemukakan gagasanuntuk mem-bangun kembali rancangbangun ilmu pengetahuan berdasarkanpada prinsip-prinsip Islam, bahkanpada tahun 70- an Syed MuhammadNaquib al-Attas sudah pula menggagashal ini. Namun demikian, perbincanganmasalah islamisasi ilmuKeyword:Islamisasi, Ilmu Pengetahuan
DAFTAR ISI JURNAL Progresifa Vol 4, Nomor 1, Agustus 2010
Authors: Isi Daftar
Published: April 2020

DAFTAR ISI1 – 20 RomlahPENGEMBANGAN MODEL PEMBELAJARAN PENDIDIKAN AGAMA ISLAM (PAI) BERBASIS CONTEXTUAL TEACHING AND LEARNING (CTL), SEBAGAI UPAYA MENINGKATKAN KUALITAS PEMBELAJARAN GURU, DI SMP KOTA MALANG21 – 32 Moh. NurhakimREKONSTRUKSI PEMIKIRAN A. MALIK FADJAR TENTANG PEMBAHARUAN MADRASAH MENUJU SEKOLAH MODEL33 – 44 Fita MasrurohDAMPAK SERTIFIKASI SEBAGAI PROGRAM PENINGKATAN PROFESIONALISME GURU TERHADAP KESEJAHTERAAN DAN KINERJA GURU45 – 60 HN. TaufiqPOLA PEMBINAAN KEAGAMAAN DAN AKHLAK MAHASISWA (Studi Kasus di Universitas Muhammadiyah Malang)61 – 70 FaridiPERSEPSI MAHASISWA TERHADAP MATA KULIAH AL ISLAM DAN KEMUHAMMADIYAHAN (AIK): INTERNALISASI NILAI‐NILAI AIK BAGI MAHASISWA71 – 82 SunartoSTUDI HUMAS DI MADRASAH ALIYAH MUHAMMADIYAH 1 MALANG83 – 104 Chandra M.PRESERVASI AL‐QUR’AN DALAM MENDIDIK MORAL105 – 114 Ahmad FathoniSTRATEGI PENGAJARAN ILMU MA’ANI115 – 124 Saiful AmienANALISIS DESAIN PESAN PEMBELAJARAN BAHASA ARAB DALAM BUKU AJAR AL‐‘ARABIYAH BAINA YADAIK LEVEL 1125 – 136 Erik BudiantoPENDIDIKAN KARAKTER MELALUI PEMBELAJARAN PAI BERBASIS KONTEKSTUAL
Teologi Toleransi; Dari Toleransi Recognize menuju Toleransi Nilai
Authors: Hanafi Imam
Published: April 2020

This article wants to redefine tolerance, it also wants to show that religious plurality becomes a necessity that cannot be sued. In addition, this article wants to see the negative side of the emergence of a single logical reasoning on religious truth. This topic is examined using a qualitative-descriptive approach, emphasizing the importance of humans being actively tolerant, reviving values in the natural diversity of the country. At the end of this article, the author also wants to show that plurality as a necessity, can be read from theological perspective. Therefore, the reconstruction of Islamic theology is needed to re-read the meaning of true tolerance.
Povos Indígenas e plano diretor de Araquari, SC: presença Guarani na conservação da biodiversidade
Authors: Nunes Jr. Orivaldo
Published: April 2020

O Planejamento Territorial no nordeste de Santa Catarina, Brasil, passa pela elaboração do Plano Diretor nos municípios onde o Povo Indígena Guarani habita milenarmente como parte de seu extenso Território (ES, RJ, SP, PR, SC, RS, Uruguai, norte da Argentina, Paraguai Oriental e Bolívia Oriental) e suas Terras Indígenas no município de Araquari, SC, estão em processo de regularização pela União conforme Art. 231 da Constituição Federal de 1988. Assim, este artigo busca analisar as alterações nas áreas de vegetação deste território Guarani em Araquari, SC, que envolve áreas de vegetação, Terras Indígenas e seu entorno, desde as décadas de 1980 a 2010. Demonstraremos a importância da presença Indígena Guarani para a conservação da Biodiversidade no âmbito das discussões do Plano Diretor municipal.
Editorial
Authors: Tonezer Cristiane , Fossá Juliano Luiz
Published: April 2020

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Comparative analysis of the infrastructure basis for the transition to the digital economy of Latin America
Authors: Revinova Svetlana Yu. , Chavarry Galvez Diana Pamela
Published: April 2020

In the last decade, almost all countries of the world have developed strategies for the transition to a digital economy. The introduction of digital technologies is observed in all spheres of our life: from simple household consumption to public administration. Latin American countries have not been left out of this process. However, the readiness for such a transition varies for the countries of the region. The purpose of this article is a comparative analysis of the infrastructure base of Latin American countries for the transition to a digital economy. The starting point for this transition is the provision of public access to the Internet and the ability of the population to take advantage of the opportunities provided by digital technologies. The basis for the study was the database of the World Bank, the online portal “Statista” and other open sources. Comparison and pattern matching methods were used in the process. The analysis showed that Chile, Argentina, Uruguay, Costa Rica are among the leading countries in the readiness of the infrastructure base for the transition to a digital economy. Countries lagging in this indicator - Haiti, Nicaragua, Honduras, Venezuela. It is noted that in these countries it is necessary to create new institutions, stimulate innovation. In general, the Latin American region at the moment belongs to the middle group of digitalization but has great potential and good prospects.