bluuebunny/crossref_metadata_2025 huggingface dataset:
The Relationship between Resiliency, Psychological Empowerment, and Teacher Burnout across Different Genders: A Psychological Network Analysis
Authors: Xue Danni , Sun Binghai , Li Weijian , Li Xinwei , Xiao Weilong
Published: September 2024

Teacher burnout is one of the main reasons leading to decreased teaching performance and occupational mental health issues among teachers, drawing widespread global attention. Previous research has found that both resiliency and psychological empowerment can alleviate teacher burnout, yet there is no study simultaneously examining the relationships between resiliency, PE, and teacher burnout. Furthermore, previous studies have found gender differences in teacher burnout but have not examined the moderating effects of resiliency and psychological empowerment by gender group. Additionally, traditional analytical methods may overlook the compositional connections between these variables. To bridge this gap, we employed psychological network analysis to evaluate the psychological network of teachers with burnout across different genders. Findings indicate: (1) Female teachers exhibit a stronger link between their sense of departmental control and burnout, while male teachers show a stronger connection between solving instructional challenges and burnout. (2) Patience in male teachers’ approach to teaching may enhance connections with their environment, and mastering job-relevant skills can boost male teachers’ job happiness. (3) Female teachers’ “I feel connected to others” demonstrates higher bridge centrality. In comparison, male teachers’ “My work is vital to me” shows higher bridge centrality, indicating deeper connections with other symptom clusters. This study reveals the complex interactions among the factors of teacher burnout and investigates how gender differences influence the associations between these factors and burnout, by not only filling gaps in previous research but also offering new perspectives and strategies for understanding and intervening in teacher burnout, especially in the context of gender differences.
The Use of Waste Low-Density Polyethylene for the Modification of Asphalt Mixture
Authors: Kovács Róbert , Czímerová Adriana , Fonód Adrián , Mandula Ján
Published: September 2024

In this study, a critical evaluation and the benefits of using a waste and a virgin polymer in an asphalt mixture are presented. The present paper is the result of a three-year research effort to find a suitable recyclate compatible with asphalt binder and setting reaction conditions in the preparation of asphalt mixtures with the mentioned recyclate. This suitable candidate was recycled low-density polyethylene (LDPE), which was produced by recycling old, worn-out bags and films. An amount of 6% of LDPE by the weight of the binder content was suggested as the best amount of the modifier. Physical tests, including penetration, softening point, and kinematic viscosity have been carried out to prove the effectiveness of the modification on the binder properties. The effectiveness of the blending process and the appropriate concentration of additives led to a homogeneous polymer-modified bitumen without any imperfections in the structure. After successful preparation under laboratory conditions, this paper describes the preparation of asphalt mixtures directly in an asphalt-mixing plant and the subsequent implementation of a verification section. The overall composition of prepared polymer-modified asphalt mixtures has been studied. An important result of this study is the preparation of the asphalt mixture with waste LDPE that meets all the technical requirements. Moreover, it has been proven that this type of waste PE is fully applicable in asphalt-mixing plants in Slovakia, with zero or minimal financial burden on construction companies to complete the construction of their production facilities. Using such a technology, we can reduce the amount of waste plastics that otherwise end up in landfill.
Research on Temperature Control of Mass Concrete for Multi-Tower Cable-Stayed Bridge Cap during Construction
Authors: Sun Sheng , Zhang Yongtao , Lv Yanjun , Xu Xingshuang , Wang Zhihao , Liu Zujun
Published: September 2024

In the construction process of mass concrete structures, the large temperature gradient due to exothermic hydration makes the mass concrete highly susceptible to cracking. This paper carried out research on temperature control methods of mass concrete for the purpose of ensuring construction quality based on the construction of Fengyi cable-stayed bridge caps. Firstly, the temperature and stress change rule in the concrete pouring process of the caps was analyzed though the finite element method (FEM). Then, targeted-oriented comprehensive temperature control schemes were formulated according to the structural characteristics and construction environment of the cap, including the optimization of the material ratio, the arrangement of crack-resistant reinforcing steel, the design of a water pipe cooling scheme and reasonable maintenance. Finally, the whole bridge cap construction process using the optimized water pipe cooling solution was monitored, and the temperature gap between inside and outside the concrete satisfied the specification requirements rigorously. In the concrete demolding session, the concrete surface was smooth and no cracks were found, which indicates the temperature control scheme is reasonable and effective. The research results have reference significance for the pouring and temperature control of mass concrete for bridge caps.
Exploring Bid/No-Bid Decision Factors of Construction Contractors for Building and Infrastructure Projects
Authors: Aldossari Khaled Medath
Published: September 2024

While contractors may experience financial failure if they bid on an inappropriate project, bidding on the right project may allow them to profit substantially. Therefore, understanding the various factors that influence the bid/no-bid decision is crucial for construction companies in determining whether to pursue a project. The present study aims to identify the critical factors influencing contractors’ bid/no-bid decisions. A total of 112 responses were collected from a questionnaire survey to rate the relative importance of 22 factors, and these factors were then analyzed based on the type of project and the contractor’s years of experience. The results indicate that the client’s ability to pay, clarity of the scope of work, project cash flow, the need for work, and availability of qualified labor are the most critical factors influencing contractors when making bid/no-bid decisions. The factor “previous experience in similar projects” was statistically significant among building and infrastructure projects, while “project location” was statistically significant among contractors with different years of experience. Finally, factor analysis identifies the six major underlying groups: client-related factors, bidding-related factors, contractor-related factors, market-related factors, economy-related factors, and project-related factors. The study’s findings can help contractors better understand the factors influencing their bidding-related decisions.
Enhancing Construction Management Education through 4D BIM and VR: Insights and Recommendations
Authors: Abouelkhier Narmin , Shafiq Muhammad Tariq , Rauf Abdul , Alsheikh Negmeldin
Published: September 2024

Traditional teaching methods in construction management education often face challenges in providing students with practical, real-world experiences crucial for skill development. To address these limitations, this study explores the potential of integrating building information modeling (BIM) and virtual reality (VR) as educational tools for construction management students. Our aim is to assess the effectiveness of a 4D-BIM-based VR simulation in enhancing student’s learning experiences and performance in construction project management. This research employs a mixed-method approach, combining quantitative data and qualitative insights from a comparative experiment involving undergraduate students. Quantitative data were collected through objective error detection measures in construction sequences and processes, while qualitative insights were gathered from participant feedback. The findings highlight that students using VR-based simulations detected more errors in construction sequences and processes than in traditional 2D drawings, showcasing the utility of BIM and VR-enabled approaches in teaching construction management. This study contributes to the ongoing discourse on integrating advanced technologies into educational practices, particularly in construction management, where practical hands-on experiences are crucial for skill development and real-world application.
The Challenges of Earthen Architecture from a Conservation Perspective: St Bartholomew Anglican Church, Wusasa, Nigeria
Authors: Shittu Theophilus A. , Odiaua Ishanlosen
Published: September 2024

This article is a critical analysis of the conservation of a historic earth building: the Saint Bartholomew’s Church in Nigeria. It presents the conservation actions carried out through the application of conservation principles adapted to local context and contributes to building knowledge regarding building conservation in Africa. The conservation actions consisted of diagnostics, technical interventions and developing guidance for future maintenance of the building. The conservation was carried out between August 2021 and April 2023. A dualistic approach that combines local resources and internationally acceptable conservation practices was employed in the conservation of the church. This approach ensured that the appropriate interventions were carried out on the church building fabric simultaneously with training and knowledge exchange between experts from Nigeria and the UNESCO World Heritage site in Djenne, Bamako, Mali. This article highlights the challenges of conserving earthen architectural conservation in the 21st century and how these challenges can be mitigated through repair and documentation.
Material Design and Performance Study of a Porous Sound-Absorbing Sound Barrier
Authors: Cai Lili , Mo Yiran , Yang Suofan , Lu Yaxin , Qian Xiaobin , Lv Chenglin , Zhang Dong , You Chuanhui
Published: September 2024

A new type of porous sound-absorbing sound barrier was developed with quartz sand and self-developed polysiloxane resin. The forming process of the material was studied. The test specimens of the porous sound-absorbing sound barrier were prepared with different mesh numbers of quartz sand and different proportions of resin, and the void properties, compressive strength, durability, and acoustic performance were investigated. Based on the mix design results, it is suggested that 20-mesh quartz sand and a 10:1 mass ratio of quartz sand are used to prepare the porous sound-absorbing sound barrier. The durability study showed that the porous sound-absorbing sound-barrier material had good salt and alkali resistance, poor acid resistance, good water stability, and freeze–thaw stability. The laboratory acoustic test and practical engineering application results showed that the porous sound-absorbing sound barrier had excellent acoustic performance and good noise-reduction effects.
Optimization of Shear Resistance in Horizontal Joints of Prefabricated Shear Walls through Post-Cast Epoxy Resin Concrete Applications
Authors: Chen Peiqi , Zhao Shilong , Xu Pengzhan , Zhou Xiaojie , Li Yueqiang
Published: September 2024

The horizontal joint is a critical component of the prefabricated shear wall structure, responsible for supporting both horizontal shear forces and vertical loads along with the wall, thereby influencing the overall structural performance. This study employs direct shear testing and finite element analysis to investigate the horizontal joint in walls with ring reinforcement. It examines the impact of various factors on joint shear performance, including the type of joint material, joint configuration, buckling length of ring reinforcement, strength of precast concrete, reinforcement ratio of ring reinforcement and dowel bars, and the effect of horizontal binding force. The findings indicate that the shear bearing capacity and stiffness of joints incorporating post-cast epoxy resin concrete and keyways are comparable or superior to those of integrally cast specimens. A larger buckling length in ring reinforcement may reduce shear strength, suggesting an optimal buckling length at approximately one-third of the joint width. As the strength of precast concrete increases, ductility decreases while bearing capacity increases, initially at an increasing rate that subsequently declines. Optimal results are achieved when the strength of precast concrete closely matches that of the post-cast epoxy concrete. Enhancing the reinforcement ratio of ring reinforcement improves shear capacity, but excessively high ratios significantly reduce ductility. It is recommended that the diameter of ring reinforcement be maintained between 10 mm and 12 mm, with a reinforcement ratio between 0.79% and 1.13%. Increasing horizontal restraint enhances stiffness and shear capacity but reduces ductility; thus, the axial compression ratio should not exceed 0.5.
Driving Sustainable Cultural Heritage Tourism in China through Heritage Building Information Modeling
Authors: Zhou Zhiwei , Liu Zhen , Wang Genqiao
Published: September 2024

In recent years, applying building information modeling (BIM) digital technologies to cultural heritage management, monitoring, restoration, with the objective of advancing the sustainable development of both cultural heritage protection and tourism in China, has become a prominent research focus. However, there are a few studies that comprehensively investigate the relationship between BIM, Chinese cultural heritage, and sustainable tourism development. In order to explore the application of BIM in the protection and inheritance of Chinese cultural heritage, as well as its potential in promoting the sustainable development of cultural heritage tourism, this paper adopts the quantitative research method of bibliometrics to explore the research hotspots, development background, and evolution trends of BIM-driven sustainable development in Chinese cultural heritage tourism. By using data obtained from the China Knowledge Network database, multi-level bibliometrics analysis has been conducted through visualized knowledge graphs. The results suggest that the popular research keywords for driving sustainable cultural heritage tourism in China through BIM since year 2000 (23 years) include heritage tourism, heritage protection, building heritage, digital technology, and tourism development. Three research hotspots have been identified, which are cultural heritage protection, cultural heritage tourism development, and cultural heritage tourism management. In terms of tourism development and management, building virtual interactive scenes of cultural heritage facilitated by BIM to enhance tourism experience of tourists, using BIM to assist in efficient management, intelligent decision-making, and personalized services of cultural heritage tourism, assist in better promoting the sustainable development of cultural heritage tourism. In terms of coordinating and managing stakeholders in cultural heritage tourism, BIM technology provides technical support to the government, industry managers, and community residents in information communication, and industry management by constructing a digital model of cultural heritage to better balance the rights and interests of stakeholders.
Research on Thermal Comfort Evaluation and Optimization of Green Space in Beijing Dashilar Historic District
Authors: Qi Ling , Li Tianjing , Chang Biyun , Xiong Wen
Published: September 2024

Global warming and urban heat island effects negatively impact the development of urban thermal environments, making them very uncomfortable to live in. Green space plays an essential role in controlling and improving air pollution, regulating the microclimate, and enforcing compliance with public health requirements. Therefore, this study explored the relationship between green space and thermal comfort in the historical neighborhood of Dazhalan in Beijing through questionnaires, observational interviews, and numerical simulations. The current situation of the microclimate environment in the green space of the block was observed first. Then, the microclimate environment was simulated by the ENVI-met 5.6 software. The thermal comfort of the three types of space, such as enclosed space, strip space, and corner space, was also evaluated to explore the coupling relationship between different green space elements and microclimate evaluation factors. It was found that the thermal comfort PET had a positive correlation with the sky openness SVF. The green space morphology was quantitatively measured, and it was found that the thermal comfort PET had a negative correlation with the three-dimensional green quantity of green space. The paper developed managing strategies for optimizing the layout and construction mode of the green space. The ultimate goal was to rationally match the greening planting, improve the pavement of the underlying surface of the block, and optimize the design of the internal space topography.
Impact of Nano-SiO2 on the Compressive Strength of Geopolymer-Solidified Expansive Soil
Authors: Hu Jianlin , Zhao Tianyi , Jia Jilong , Guo Jiangfeng , Yang Wenlong , Dong Shaohui , Li Zhilin , Gao Tongtong
Published: September 2024

Expansive soil is widely distributed and often needs to be improved for engineering and construction needs. Using blast furnace slag and fly ash as precursors and NaOH as an alkali activator, a geopolymer was prepared to solidify expansive soil, and the effect of nano-SiO2 on the compressive strength and water stability of the geopolymer-solidified expansive soil was further studied. The effects of alkali addition ratio, nano-SiO2 addition ratio, and curing agent addition ratio on the unconfined compressive strength and water stability of the cured soil were studied through unconfined compressive strength tests, and the curing mechanism was analyzed by electron microscopy scanning. The experimental results showed that the unconfined compressive strength and water stability of geopolymer-stabilized soil first increased and then decreased with an increase in alkali activator dosage. The optimal dosage of alkali activator was found to be 12.5%. Furthermore, it was found that adding nano-SiO2 can further enhance the strength and water stability of solidified soil. When the content of nano-SiO2 was 3%, the unconfined compressive strength was increased by 15%. With an increase in the content of nano-SiO2 doped polymer (GFNS), the unconfined compressive strength and water stability of the solidified soil showed a trend of first increasing and then decreasing, reaching a peak at a content of 20%. The cementitious materials, such as hydrated calcium silicate and hydrated calcium silicate aluminate, generated by the reaction between nano-SiO2 and geopolymer played a role in bonding and filling in the solidified soil. Under the joint action of the two, the structural arrangement between the solidified soil particles became more compact, which improved the strength of the solidified soil.
Tensile Performance and Aging Increase Factor Constitutive Model of High-Strength Engineered Cementitious Composites under Sulfate Salt Attack
Authors: Li Yangke , Wang Jingyun , Yang Yi , Tang Tengfei
Published: September 2024

This study investigates the uniaxial tensile behavior of high-strength engineered cementitious composites (HS-ECCs) in sulfate erosion environments. Five different sulfate erosion ages were established (0 days, 30 days, 60 days, 90 days, and 120 days), and the development of the macro-mechanical properties of HS-ECCs was revealed from a microscopic perspective using scanning electron microscopy (SEM). The results indicate that, under the influence of sulfate erosion, the strength of HS-ECCs exhibits a trend of initial increase followed by a decrease, while ductility shows a continuous decline. This phenomenon is primarily attributed to changes in the microstructure and reaction products. Based on the test results, an aging growth factor was introduced to fit the stress–strain curve, demonstrating that the model can effectively predict the tensile performance of HS-ECCs with greater accuracy compared to traditional models. This study not only provides data references for the engineering application of HS-ECCs in sulfate environments but also offers a novel approach for constructing predictive models in other environmental contexts.
Evaluating the Impact of Elementary School Urban Neighborhood Color on Children’s Mentalization of Emotions through Multi-Source Data
Authors: Zhang Ruiying , Huang Qian , Peng Zhimou , Zhang Xinyue , Shang Lan , Yang Chengling
Published: September 2024

To address the challenge of quantitatively assessing the mentalization of emotions in color design schemes, this study uses Baidu Street View images and deep learning, integrates multi-source data, and innovatively constructs a color data model based on a comprehensive color indicator system for the quantitative assessment and visual representation of how the color environments of elementary school urban neighborhoods impact children’s mentalization of emotions. This model systematically incorporates physical color indicators, integrates elements such as perceptual frequency, and provides a novel perspective for color planning. The study’s results reveal that color metrics significantly impact children’s mentalization of emotions across multiple dimensions, with gender and age emerging as important influencing factors. Additionally, significant correlations were found between color and environmental elements such as building façades, roads, and signs. The study provides urban planners and architects with a practical color data model and recommendations for the revitalization of elementary school urban neighborhoods, offering a scientific basis for optimizing color design.
Experimental Study and Design Method of Cold-Formed Thin-Walled Steel Unequal-Leg Angles under Axial Compression
Authors: Guo Yanli , Nie Zeyu , Yao Xingyou , Liu Yilin , Chen Chong , Zeng Kaihua
Published: September 2024

An experimental study of cold-formed thin-walled steel unequal-leg angles (CFTWS-ULAs) under axially oriented pressure is presented in this paper. Firstly, the initial imperfections and material properties of the angle specimens were measured in detail. The angle specimens were tested under fixed-ended conditions. The results of the experiments showed that the angle specimens with small slenderness ratios were susceptible to local buckling, the angle specimens whose legs had high slenderness ratios and low width–thickness ratios were found to easily suffer from the occurrence of flexural buckling, and the angle specimens whose legs had high width–thickness ratios were found to easily suffer from the occurrence of interactive buckling between local buckling and flexural buckling. The finite element analysis of the ULAs was conducted using ABAQUS6.14 finite element software by creating a model. The buckling modes and ultimate bearing capacities of the test specimens were compared, and the finite element analysis verified that the established model built using the finite element is credible and subsequent parametric analysis was performed. The slenderness ratio had the most significant impact on the ultimate bearing capacities of the unequal-leg angles, as indicated by the analysis results. When the width–thickness ratio and the width ratio of the legs fell within a specific range, the ultimate bearing capacities of the unequal-leg angles increased as the width–thickness ratio and the width ratio of the legs increased. Finally, the comparison results showed that the design strengths predicted by the specifications were very conservative, because the local buckling and torsional buckling were calculated at the same time. Therefore, a recommendation was proposed that the calculation of the load-carrying capacity of an unequal-leg angle should ignore torsional buckling.
Biphenotypic Sinonasal Sarcoma with Orbital Invasion: A Literature Review and Modular System of Surgical Approaches
Authors: Corvino Sergio , de Divitiis Oreste , Iuliano Adriana , Russo Federico , Corazzelli Giuseppe , Cohen Dana , Di Crescenzo Rosa Maria , Palmiero Carmela , Pontillo Giuseppe , Staibano Stefania , Strianese Diego , Elefante Andrea , Mariniello Giuseppe
Published: September 2024

Background: Biphenotypic sinonasal sarcoma is a rare low-grade tumor arising from the sinonasal tract, featuring locally aggressive biological behavior, with a tendency to invade the orbit and skull base. There are no defined guidelines of treatment; thus, the management varies among different institutions. The aim of the present study is to provide a modular system of surgical approaches according to the lesion pattern of growth from a literature review. Materials and Methods: A comprehensive and detailed literature review on the PubMed and Embase online electronic databases on biphenotypic sinonasal sarcoma with orbital invasion was conducted. A personal case exhibiting peculiar features was also added. Demographic (patient’s sex and age), clinical (presenting symptoms and time to treatment), neuroradiological (anatomical origin and pattern of growth), and treatment (type of treatment, surgical approach, extent of resection, peri- and postoperative complications, and adjuvant therapies) data, as well as clinical outcome, recurrence rates, and overall survival, were analyzed. Results: Thirty-one patients harboring biphenotypic sinonasal sarcoma with orbital invasion were identified. Tumors mainly affected female patients (66.7%) and a middle-aged population (median 55.2 years old). Simultaneous skull base involvement occurred in most cases (80.6%). Surgery was performed in all but one case (97%), as unique treatment (59%) or in association with radio—(23.5%) and/or chemotherapy (5.9%/2.9%), allowing for gross total tumor resection in most cases (66.7%). The endoscopic endonasal approach was the most adopted surgical corridor (51.7%). The local recurrence rate was 19.3%, and only two cases of tumor-related mortality occurred. Conclusions: Surgery is the only curative treatment, with the main goal to restore/improve/arrest progression of clinical manifestations. The endoscopic endonasal route represents the master approach for lesions confined to the midline. Microsurgical transcranial and endoscopic transorbital approaches have a complementary role for addressing the lesion’s component with large intracranial extension or affecting the paramedian aspect of the anterior cranial fossa and superior–lateral orbital compartment, respectively. The approach selection should be made case by case according to the tumor pattern of growth.
The Application of Large Language Models in Gastroenterology: A Review of the Literature
Authors: Maida Marcello , Celsa Ciro , Lau Louis H. S. , Ligresti Dario , Baraldo Stefano , Ramai Daryl , Di Maria Gabriele , Cannemi Marco , Facciorusso Antonio , Cammà Calogero
Published: September 2024

Large language models (LLMs) are transforming the medical landscape by enhancing access to information, diagnostics, treatment customization, and medical education, especially in areas like Gastroenterology. LLMs utilize extensive medical data to improve decision-making, leading to better patient outcomes and personalized medicine. These models are instrumental in interpreting medical literature and synthesizing patient data, facilitating real-time knowledge for physicians and supporting educational pursuits in medicine. Despite their potential, the complete integration of LLMs in real-life remains ongoing, particularly requiring further study and regulation. This review highlights the existing evidence supporting LLMs’ use in Gastroenterology, addressing both their potential and limitations. Recent studies demonstrate LLMs’ ability to answer questions from physicians and patients accurately. Specific applications in this field, such as colonoscopy, screening for colorectal cancer, and hepatobiliary and inflammatory bowel diseases, underscore LLMs’ promise in improving the communication and understanding of complex medical scenarios. Moreover, the review discusses LLMs’ efficacy in clinical contexts, providing guideline-based recommendations and supporting decision-making processes. Despite these advancements, challenges such as data completeness, reference suitability, variability in response accuracy, dependency on input phrasing, and a lack of patient-generated questions underscore limitations in reproducibility and generalizability. The effective integration of LLMs into medical practice demands refinement tailored to specific medical contexts and guidelines. Overall, while LLMs hold significant potential in transforming medical practice, ongoing development and contextual training are essential to fully realize their benefits.
Safety Evaluation of Carbon Dots in UM-UC-5 and A549 Cells for Biomedical Applications
Authors: Magalhães Carla M. , Ribeiro Eduarda , Fernandes Sónia , Esteves da Silva Joaquim , Vale Nuno , Pinto da Silva Luís
Published: September 2024

Backgroung: The rising complexity and associated side effects of cancer treatments highlight the need for safer and more effective therapeutic agents. Carbon-based nanomaterials such as CDs have been gaining prominence for their unique characteristics, opening avenues for diverse applications such as fluorescence imaging, drug and gene transport, controlled drug delivery, medical diagnosis, and biosensing. Despite promising advancements in research, it remains imperative to scrutinize the properties and potential cytotoxicity of newly developed CDs, ensuring their viability for these applications. Methods: We synthesized four N-doped CDs through a hydrothermal method. Cell viability assays were conducted on A549 and UM-UC-5 cancer cells at a range of concentrations and incubation times, both individually and with the chemotherapeutic agent 5-fluorouracil (5-FU). Results: The obtained results suggest that the newly developed CDs exhibit suitability for applications such as bioimaging, as no significant impact on cell viability was observed for CDs alone.
Evolution of Liquid Biopsies for Detecting Pancreatic Cancer
Authors: Munnings Ryan , Gibbs Peter , Lee Belinda
Published: September 2024

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy characterised by late diagnosis and poor prognosis. Despite advancements, current diagnostic and prognostic strategies remain limited. Liquid biopsy techniques, including circulating tumour DNA (ctDNA), circulating tumour cells (CTCs), circulating tumour exosomes, and proteomics, offer potential solutions to improve PDAC diagnosis, prognostication, and management. A systematic search of Ovid MEDLINE identified studies published between 2019 and 2024, focusing on liquid biopsy biomarkers for PDAC. A total of 49 articles were included. ctDNA research shows some promise in diagnosing and prognosticating PDAC, especially through detecting mutant KRAS in minimal residual disease assays. CTC analyses had low sensitivity for early-stage PDAC and inconsistent prognostic results across subpopulations. Exosomal studies revealed diverse biomarkers with some diagnostic and prognostic potential. Proteomics, although relatively novel, has demonstrated superior accuracy in PDAC diagnosis, including early detection, and notable prognostic capacity. Proteomics combined with CA19-9 analysis has shown the most promising results to date. An update on multi-cancer early detection testing, given its significance for population screening, is also briefly discussed. Liquid biopsy techniques offer promising avenues for improving PDAC diagnosis, prognostication, and management. In particular, proteomics shows considerable potential, yet further research is needed to validate existing findings and comprehensively explore the proteome using an unbiased approach.
Systemic Therapy of Gastric Cancer—State of the Art and Future Perspectives
Authors: Lordick Florian , Rha Sun Young , Muro Kei , Yong Wei Peng , Lordick Obermannová Radka
Published: September 2024

Background: The prognosis of patients diagnosed with locally advanced and metastatic gastric and esophago-gastric junction cancer is critical. The optimal choice of systemic therapy is essential to optimize survival outcomes. Methods: A comprehensive literature review via PubMed and analysis of major oncology congresses (European Society for Medical Oncology and American Society of Clinical Oncology websites) were conducted to ascertain the current status and latest developments in the systemic treatment of patients with localized or advanced gastric and esophago-gastric junction adenocarcinoma. Results: While neoadjuvant and perioperative chemotherapy for localized tumor stages is the preferred approach in the Western Hemisphere, adjuvant chemotherapy remains the preferred course of action in East Asia. The administration of chemotherapy, typically in the form of combinations comprising platinum and fluoropyrimidine compounds in combination with docetaxel, represents a standard of care. Investigations are underway into the potential of immunotherapy and other biologically targeted agents in the perioperative setting. To select the most appropriate therapy for advanced gastric cancer, including adenocarcinoma of the esophago-gastric junction, it is essential to determine biomarkers such as HER2 expression, PD-L1 combined positive score (CPS) (combined positive score), Claudin 18.2, and microsatellite instability (MSI). In the present clinical context, the standard first-line therapy is a combination of fluoropyrimidine and a platinum derivative. The selection of chemotherapy in combination with antibodies is contingent upon the specific biomarker under consideration. Conclusions: This article reviews the current state of the art based on recent clinical trial results and provides an outlook on the future of systemic therapy.
Use of Radioguided Surgery for Small and Difficult-to-Locate Relapsed MIBG (+) High-Risk Neuroblastoma Lesions
Authors: Krauel Lucas , Pasten Albert , Gorostegui Maite , Mañé Salvador , Martin Giménez Marta Pilar , Coronas Maria , Carrasco Torrents Rosalia , Mora Jaume
Published: September 2024

Introduction: High-risk neuroblastoma, particularly in the relapse/refractory (R/R) setting, poses unique challenges to obtaining the representative-quality tissue that is mostly required for molecular analysis. This study explores the use of 123I-MIBG radioguided surgery to access complex locations of MIBG-positive neuroblastoma as a tool to overcome the difficulties associated with repeated surgeries in these patients. Methods: This study is a retrospective review of all patients with R/R neuroblastoma and MIBG-uptaking lesions who underwent radioguided surgery between February 2020 and 2023 at SJD Barcelona Children’s Hospital. The Europrobe 3.2 gamma probe was used to identify neuroblastoma tissue in the operating room. Results: Ten patients were identified. Radioguided surgery was useful in all patients. One patient with previous multiple operations developed an entero-cutaneous fistula with posterior full recovery. Mean surgical time was 111.7 min. The gamma probe identified 100% of neuroblastoma lesions which were all completely removed (123I-MIBG-SPECT/CT negative post-surgery). Pathology and molecular studies could be successfully performed in all samples. Conclusions: 123I-MIBG radioguided surgery proved effective in obtaining viable tissue from difficult-to-access sites in high-risk relapsed neuroblastoma.
Short-Term Postoperative Outcomes after Resective Colorectal Surgery in Elderly vs. Nonelderly Patients: A Single Centre Retrospective Analysis
Authors: Tondolo Vincenzo , Marzi Federica , Amodio Luca Emanuele , Rizzo Gianluca
Published: September 2024

Background/Objectives: Life expectancy for people in their 60s is 24.3 years in high-income countries. Health systems face the burden of disease in the elderly population and must assess the impact of treatments such as major surgery. The aim of this study is to quantify the impact of advanced age on short-term postoperative outcomes after resective colorectal surgery (RCRS). Methods: All patients who underwent RCRS at our institution between July 2022 and November 2023 were entered into a database. Preoperative, perioperative, and early (within 30 days) postoperative data were recorded. Patients were categorized into a young group (under 75 years, YG) and an elderly group (over 75 years, EG). A retrospective comparative analysis of postoperative outcomes was performed between the two groups; postoperative complications were graded according to the Clavien classification. Results: Fifty-three and ninety-five patients were in the EG and YG, respectively. Indications for RCRS was cancer in 83% of EG patients and 61.1% of YG patients (p = 0.006), and the clinical presentation, localization, and rate of neoadjuvant treatment in oncological patients were comparable. Another indication for RCRS was complicated diverticular disease (17% of EG patients and 38.9% of YG patients; p = 0.006). With respect to the baseline characteristics, the ASA and CCI scores were worse in the EG (p = 0.001). No significant differences in the surgical approach, mini-invasive approach, conversion rate, definitive stoma creation, or number of harvested lymph nodes were found between the two groups. Overall, EG reported a higher relative risk (RR) of short-term postoperative complications (1.64, CI: 1.03–2.63), but no significant differences were found in terms of grade ≥3 complications (RR: 0.9, CI: 0.23–3.44). In the EG, a higher risk of ICU admission (RR:2.69, CI: 1.5–4.8) and a one-day longer postoperative hospital stay (6 vs. 5 days) were reported. Conclusions: Advanced age does not seem to contraindicate RCRS, especially in colorectal cancer patients. The impact of elderly age on short-term outcomes seems to be minimal and acceptable.
Histone Deacetylase Inhibitors for Peripheral T-Cell Lymphomas
Authors: Irimia Ruxandra , Piccaluga Pier Paolo
Published: September 2024

Histone deacetylase inhibitors (HDACis) are being recognized as a potentially effective treatment approach for peripheral T-cell lymphomas (PTCLs), a heterogeneous group of aggressive malignancies with an unfavorable prognosis. Recent evidence has shown that HDACis are effective in treating PTCL, especially in cases where the disease has relapsed or is resistant to conventional treatments. Several clinical trials have demonstrated that HDACis, such as romidepsin and belinostat, can elicit long-lasting positive outcomes in individuals with PTCLs, either when used alone or in conjunction with conventional chemotherapy. They exert their anti-tumor effects by regulating gene expression through the inhibition of histone deacetylases, which leads to cell cycle arrest, induction of programmed cell death, and,the transformation of cancerous T cells, as demonstrated by gene expression profile studies. Importantly, besides clinical trials, real-world evidence indicated that the utilization of HDACis presents a significant and beneficial treatment choice for PTCLs. However, although HDACis showed potential effectiveness, they could not cure most patients. Therefore, new combinations with conventional drugs as well as new targeted agents are under investigation.
Prognostic Study of Colorectal Cancer: Differences between Screen-Detected and Symptom-Diagnosed Patients
Authors: Novotny Sergio A. , Rodrigo Amador Vidina A. , Seguí Orejuela Jordi , López-Pineda Adriana , Quesada José A. , Pereira-Expósito Avelino , Carratalá-Munuera Concepción , Hernandis Villalba Juan , Gil-Guillén Vicente F.
Published: September 2024

Background and objective: Colorectal cancer (CRC) is the leading cause of mortality in Spain, with screening programs, such as the faecal occult blood test and colonoscopy, having shown effectiveness in reducing CRC incidence and mortality. Despite these advancements, CRC screening uptake remains low in Spain, highlighting the need for studies comparing outcomes between screening-diagnosed and symptom-diagnosed patients to better understand the impact on overall survival and to quantify the clinical benefit in prognosis at diagnosis and at the end of follow-up. Methods: We conducted a retrospective cohort study with the following objectives: to compare stage at diagnosis, all-cause mortality, and disease-specific mortality among people diagnosed with CRC based on screening and based on symptoms; to identify the risk factors associated with mortality in this population; and to evaluate the effectiveness of screening on survival and early detection. Our study included people diagnosed with CRC in the public hospital of Elda (Spain) from 2014 to 2018; follow-up was until 2023 or death. Our primary outcome was all-cause mortality, which we analysed using Kaplan–Meier curves. We also investigated CRC-specific mortality and other-cause mortality. Results: Our sample included 315 people (186 with symptom-based diagnoses, 129 with screening-based diagnoses). The mean length of follow-up was 62.8 months. The screening group had a higher prevalence of a family history of CRC (p = 0.008), a distal tumour location (p = 0.002), and a cancer stage of 0 or I (p < 0.001). The symptoms group had a higher prevalence of a proximal CRC (p = 0.002), other chronic diseases (p < 0.001), and stages II, III, and IV (p < 0.001). Two variables were associated with mortality: stage IV at diagnosis and previous cancers. People with a symptom-based diagnosis had a higher prevalence of stage IV at diagnosis and a higher cumulative incidence of CRC mortality and all-cause mortality at the end of follow-up (p < 0.05). The Kaplan–Meier curves also showed a higher rate of all-cause mortality in the symptoms group throughout the follow-up. Conclusion: CRC screening enables an earlier diagnosis and improves survival. These findings support public health policies that promote accessible and effective screening.
Review of p.(Val429Met), a Variant of LDLR That Is Associated with Familial Hypercholesterolemia
Authors: Jotch Eric F. , Kindy Mark S.
Published: September 2024

Patients affected by familial hypercholesterolemia possess elevated low-density lipoprotein cholesterol and therefore have greater risk for cardiovascular disease. About 90% of familial hypercholesterolemia cases are associated with aberrant LDLR. Over 3500 LDLR variants have been identified, 15% of which are considered “pathogenic.” Given the genetic diversity of LDLR variants, specific variants rarely receive attention. However, investigators have proposed the critical evaluation of individual variants as a method to clarify knowledge and to resolve discrepancies in the literature. This article reviews p.(Val429Met) (rs28942078) in the areas of pathology, epidemiology, lipid-lowering therapy, and genetic testing. The p.(Val429Met) variant is associated with a missense point substitution in exon 9 of chromosome 19. Biochemical studies have found severely reduced low-density lipoprotein receptor protein in autologous and heterologous expression systems. Additionally, there are inconsistencies regarding the functional classification of p.(Val429Met). Considered to be of European origin, p.(Val429Met) is found in extant populations due to founder effects. Evidence from clinical trials have also demonstrated variable responses to newer lipid-lowering therapies in patients with a p.(Val429Met) variant. Proper clinical detection and adequate genetic testing have been shown to greatly improve outcomes. Future research may be aimed at resolving discrepancies to better comprehend the implications of familial hypercholesterolemia.
The Research Progress of Ruthenium-Based Catalysts for the Alkaline Hydrogen Evolution Reaction in Water Electrolysis
Authors: Lin Bi-Li , Chen Xing , Niu Bai-Tong , Lin Yuan-Ting , Chen Yan-Xin , Lin Xiu-Mei
Published: September 2024

The performance of the cathodic hydrogen evolution reaction (HER) in alkaline water electrolysis, an attractive hydrogen production technology, is highly dependent on efficient catalysts. Ruthenium (Ru), which is more affordable than platinum (Pt) and has a metal–hydrogen bond strength comparable to that of Pt, shows exceptional catalytic activity for the alkaline HER. Consequently, in recent years, research in the field of hydrogen production through alkaline water electrolysis has increasingly focused on Ru as a key element. This review first discusses the fundamentals of the alkaline HER, including principles, factors affecting its performance, and regulation strategies for its performance improvement. The research progress of ruthenium-based catalysts for the alkaline HER is then summarized with selected examples. The electronic structures of various ruthenium nanoparticles, ruthenium-M (M = noble metals and transition metals) heterogeneous catalysts, and ruthenium-based compounds are regulated by modulating the components and ligands of Ru atoms, aiming to achieve low water dissociation energies and optimal binding energies for hydrogen (H) and hydroxyl (−OH) groups, thereby enhancing the alkaline HER catalytic performance. Finally, the problems, challenges, and future development directions of the alkaline HER are proposed.
Hierarchical Ag3VO4 Nanorods as an Excellent Visible Light Photocatalyst for CO2 Conversion to Solar Fuels
Authors: Bafaqeer Abdullah , Chennampilly Ummer Aniz , Dhamodharan Duraisami
Published: September 2024

The potential of photocatalytic CO2 conversion is significant for the production of fuels and chemicals, while simultaneously mitigating CO2 emissions and addressing environmental concerns. Despite the current drawbacks of single metal-based photocatalysts, such as lower performance, uncontrollable selectivity, and instability, this study focuses on the synthesis of Ag3VO4 nanorods using the sol–gel method. The goal is to create a highly effective catalyst for visible light-responsive CO2 conversion. The successful synthesis of Ag3VO4 nanorods with a nanorod structure, functional under visible light, resulted in the highest yields of CH4 and dimethyl ether (DME) at 271 and 69 µmole/g-cat, respectively. The optimized Ag3VO4 nanorods demonstrated performance improvements, with CH4 and DME production 6.4 times and 4.5 times higher than when using V2O5 samples. This suggests that Ag3VO4 nanorods facilitate electron transfer to CO2, offer short pathways for electron transfer, and create empty spaces within the nanorods as electron reservoirs, enhancing the photoactivity. The prolonged stability of Ag3VO4 in the CO2 conversion system confirms that the nanorod structure provides controllable selectivity and stability. Therefore, the fabrication of nanorod structures holds promise in advancing high-performance photocatalysts in the field of photocatalytic CO2 conversion to solar fuels.