bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of a novel antiapoptotic molecule, CBP13, from Colla corii asini
Authors: Han Jing , Lupala Cecylia , Zhao Chunyue , Yuan Huiping , Sun Liang , Zhou Qi , Hao Xianghui , Gu Jianjun , Liu Haiguang , Yang Ze
Published: January 2024

For thousands of years, traditional natural medicine has been well
documented to have low toxicity and good curative effects; however, the
bioactive molecules and molecular mechanisms are unclear in many cases
due to the difficulties in identifying pharmacodynamic molecules. Here,
we report the successful identification of a novel active molecule,
CPB13, with antiapoptotic functions from a natural drug (Colla corii
asini, CCA) by combining phenotypic screening with proteomics
approaches. Functional studies in cell and animal models demonstrated
that the molecule CBP13 improves the morphology and functions of
mitochondria in a dose-dependent manner and inhibits mitochondrial
protein reduction and apoptosome activity. Molecular modeling and
docking analysis revealed that CBP13 prefers a concave conformation,
which can potentially bind to human cytochrome C and Apaf-1, providing
hints regarding the molecular basis by which CBP13 inhibits the
apoptosis signaling cascade. The results indicate that CBP13 can be
developed into drugs that regulate apoptosis, providing a new avenue for
antiaging and anti-inflammatory applications.
Estimating the effect of two graph dextran-stearic acid-spermine polymers based on magnetic iron oxide nanoparticles as carrier for gene delivery
Authors: Ashtiyani Mehrnush Kazemi , Hajipour-Verdom Behnam , Satari Mohammad , Abdolmaleki Parviz , Hosseinkhani Saman
Published: January 2024

The approaches of gene therapy are represented as a premeditate modality
of gene expression which could be carried out by introducing nucleic
acids in the designated cells to treat incurable diseases such as
cancers. Non-viral carriers because of their limited side effects,
biocompatibility, simplicity and taking the advantages of electrostatic
interactions due to the physical and chemical continents have a
noticeable potential in the gene delivery systems. The low transfection
rate of non-viral vectors under physiological conditions is a
significant issue. Here, the aim of this study was to investigate the
efficacy of hydrophilic and hydrophobic groups on gene carriers such as
two synthesized amphiphilic polymer of dextran-stearic acid-spermine
(DSASP) with verified lipid and amine conjugations that associated with
Fe3O4 superparamagnetic nanoparticles to promote the target delivery and
decrease the transfection time using static magnetic field. Our findings
illustrated that magnetic nanoparticles are spherical with positive
surface charges and superparamagnetic behaviors. The DSASP–pDNA/MNPs
offered a strong pDNA condensation and protection against DNase
degradation. Significant cell viability in HEK 293T cells was explained
by spermine residues which inhibit cytochrome c release. Although
conjugations of spermine play a critical role in transfection
efficiency, amphiphilic polymer with more derivatives of stearic acid
showed better transfection yields. Therefore, DSASP amphiphilic magnetic
carriers offer new insights for gene delivery due to the amine contents
and ameliorate the uptake of complexes via cell membrane based on its
hydrophilic surface.
Rosuvastatin and fenofibrate combination in the treatment of mixed hyperlipidemia: A narrative review
Authors: Biswas Kaushik , Tiwari Ajoy , Jadhav Prachi , Goel Amit , Chanukya G V
Published: January 2024

Introduction: Patients with mixed dyslipidemia are presented with high
levels of low-density lipid cholesterol (LDL-C), triglycerides (TG), and
reduced high-density lipid cholesterol (HDL-C). Though useful in
lowering LDL-C, therapy with rosuvastatin is insufficient in optimizing
the overall lipid profile, thus putting the patient at risk of residual
cardiovascular risk. A combination of statin with other lipid-modifying
agents has been used with more efficient lipid control and
cardiovascular risk prevention. Of these, fenofibric acid is the most
frequently used, along with rosuvastatin. Methods: Authors conducted a
literature search of published literature to assess the use of
rosuvastatin and fenofibrate combination in the management of mixed
hyperlipidaemia. Results and discussion: The authors selected a total of
47 articles to be included in the review. Due to the small number of
articles and heterogeneity on the combination of rosuvastatin and
fenofibrate combination in mixed hyperlipidemia, the findings herein are
presented using narrative summaries. Based on the thorough assessment of
the selected literature, the essential themes that emerged from the
review include safety and efficacy of rosuvastatin and fenofibrate
combination, place of therapy of rosuvastatin, and fenofibrate
combination, and potential cardiovascular risk reduction with
rosuvastatin and fenofibrate combination. Conclusion: Based on the
review, the authors suggested that the combination therapy with
fenofibric acid was beneficial, well-tolerated with a similar safety
profile compared with statin monotherapy. The combination therapy of
moderate dose rosuvastatin and fenofibric acid led to a reduction of
cardiovascular risk factors via several pathways.
Cool-down Phenomenon in Differentiating Supraventricular Tachycardias
Authors: Sawalha Khalid , Gondhalekar Vikram , Klammer Nathan , Habash Fuad , Vallurupalli Srikanth , Paydak Hakan
Published: January 2024

A 63-year-old male patient with a history of hypertension, type 2
diabetes mellitus, prostate cancer and class two obesity was admitted
for altered mental status and hypertensive emergency. During his
hospital stay he developed narrow complex tachycardia and it was
difficult to definitively diagnose the underlying arrhythmia.
Observation of the cool down phenomenon on electrocardiogram allowed us
to make the diagnosis of atrial tachycardia and elegantly ruled out
other causes on the differential. We report this interesting case of
narrow complex tachycardia.
A draft genome assembly of spotted scat (Scatophagus argus): the first reference genome for Scatophagidae fish.
Authors: Huang Yuanqing , Mustapha Umar Farouk , Huang Yang , Tian Changxu , Yang Wei , Chen Huapu , Deng Siping , Zhu Chunhua , Jiang Dongneng , Li Guangli
Published: January 2024

Spotted scat (Scatophagus argus) is an economically important marine
cultured fish species in Asia, especially in Southeast China. As an XY
sex-determining type fish species, spotted scat can be used as a model
for understanding the mechanism of novel sex determination system
evolution in vertebrates. However, genomic resources of spotted scat are
lacking, and no highly contiguous reference genome has been released. In
this study, the first chromosome-level genome of spotted scat was
constructed using PacBio’s single-molecule real-time (SMRT) sequencing
and high-throughput chromosome conformation capture (Hi-C) sequencing
technologies. The genome comprised 572.42 Mb, with the contig N50 of
19.60 Mb. A total of 24,256 protein-coding genes were predicted in the
genome, and 96.30% of the predicted genes were functionally annotated.
Evolutionary analysis showed that spotted scat diverged from the common
ancestor of Japanese puffer (Takifugu rubripes) approximately 114.8
million years ago. In addition, doublesex and mab-3 related
transcription factor 1 (dmrt1), a gene associated with sex determination
process, was not found in the high-quality female genome, while it
existed in the re-sequencing data of three XY genotype male fish. The
conserved dmrt1 locus of vertebrates was substituted by its truncated
homologue (dmrt1b), which derives from dmrt1 via allelic diversification
and munitions. The genomic resources offer a strong foundation for
further research on the sex determination of spotted scat and facilitate
the understanding of the evolution of sex chromosomes in teleost
species.
Generalized Holditch Theorem for Homothetic Motions in Cp
Authors: Erişir Tülay
Published: January 2024

In this study, the planar kinematics is studied in generalized complex
plane which is a geometric representation of the generalized complex
number system. Firstly, the one parameter planar kinematic formulas for
homothetic motions in the generalized complex plane mentioned briefly.
Then, the Steiner area formula given areas of the trajectories drawn by
the points taken in generalized complex plane are obtained during the
one parameter planar homothetic motion. Finally, the Holditch theorem,
which gives the relationship between these areas of trajectories, is
expressed for homothetic motions in generalized complex plane. So, this
theorem obtained in this study is the most general form of all Holditch
theorems obtained so far.
Occurrence of Coagulation disorders in hospitalized COVID-19 patients and its relationship with disease outcome: A Cross-sectional study
Authors: Aliasgarzade shafagh , Matin Somaieh , Javaheri Nazli , Aliasgarzade Javad , aghamohammadi vahideh
Published: January 2024

Background: Evidence suggests that patients afflicted with COVID-19 are
subject to significant risks of thromboembolic complications. We aimed
to evaluate the occurrence of coagulation disorders in patients
suffering from COVID-19 and determine its relationship with the disease
outcome. Methods: This cross-sectional study was conducted on 106
COVID-19 patients who were hospitalized in Imam Khomeini Hospital,
Ardabil, Iran. After the preliminary completion of the information
forms, 3 cc of intravenous blood sample was taken from each of the
patients to check the patients’ INR, PT, CBC, and D-dimer. The patients
were monitored. Finally, the results obtained from these clinical
assessments and tests were all recorded in checklists and statistically
analyzed using SPSS Software, Version 19. Results: Of the total 106
COVID-19 patients who entered the study, 69 cases were discharged from
the hospital alive while the other 37 cases died. The mean age of the
patients was 58.99±15.94 years and 56.6% of them were male. There were
significant differences between the survived and the deceased patients
in terms of D-dimer, LDH, PT, and INR levels (p<0.05). Based
on the results of logistic regression analysis, only D-dimer was found
to have a significant effect on predicting mortality. More specifically,
with the increase of each 1 unit in D-dimer level, the mortality risk
increased by 0.99%. Conclusion: D-dimer has a higher sensitivity in
comparison with other markers of coagulation and is of relatively
greater value in terms of intensity. Compared to the high prevalence of
thrombotic events, bleeding is not that common; therefore, standard
anticoagulant therapy is highly recommended.
INCIDENCE AND PROGNOSTIC IMPACT OF NEW-ONSET ATRIAL FIBRILLATION IN PATIENTS WITH SEVERE COVID-19: A RETROSPECTIVE COHORT STUDY
Authors: Kanthasamy Vijayabharathy , Schilling Richard
Published: January 2024

Background Corona virus disease 2019 (COVID-19) contributes to
cardiovascular complications including arrhythmias due to high
inflammatory surge. Nevertheless, the common types of arrhythmia amongst
severe COVID-19 is not well described. New onset atrial fibrillation
(NOAF) is frequently seen in critically ill patients and therefore we
aim to assess the incidence of NOAF in severe COVID -19 and its
association with prognosis. Methods This is a retrospective multicentre
study including 109 consecutive patients admitted to intensive care
units (ICU) with confirmed COVID-19 pneumonia and definitive outcome
(death or discharge). The study period was between 11th March and 5th
May 2020. Results Median age of our population was 59 years (IQR 53-65)
and 83% were men. Nearly three-fourth of the population had two or more
comorbidities. 14.6% developed NOAF during ICU stay with increased risk
amongst older age and with underlying chronic heart failure and chronic
kidney disease. NOAF developed earlier during the course of severe
COVID-19 infection amongst non-survivors than those survived the illness
and strongly associated with increased in-hospital death (OR 5.4; 95%
CI 1.7-17; p=0.004). Conclusion In our cohort with severe COVID-19, the
incidence of new onset atrial fibrillation is comparatively lower than
patients treated in ICU with severe sepsis in general. Presence of NOAF
has shown to be a poor prognostic marker in this disease entity.
A Study on Diabetes Diagnosis Based on Machine Learning
Authors: Ma Xiaopu , Song Handing , Wang Bingrui
Published: January 2024

At present, the number of people suffering from diabetes is increasing.
Diabetes seriously threatens people’s life and health. Therefore, it is
necessary to establish a predictive model of diabetes, assess the risk
of diabetes and provide early warning of diabetes in time. This article
focuses on machine learning combining with diabetes. Machine learning
algorithms have good accuracy and generalization ability in dealing with
complex problems. First, we analyze the risk factors of diabetes and
divide the diabetes sample set into training set and test set. Second,
the KNN (K-Nearest Neighbor) algorithm, decision tree algorithm,
Gaussian Naive Bayes algorithm, and logistic regression linear algorithm
are used to establish machine learning models. At last, experiments show
that the decision tree classification prediction model achieves the
highest accuracy 89.2%, which can better predict and analyze diabetes.
Decision Tree Post-Pruning Without Loss Of Accuracy using the SAT-PP algorithm with An Empirical Evaluation on Oncology Data
Authors: Lazebnik Teddy , Bunimovich-Mendrazitsky Svetlana
Published: January 2024

Decision tree (DT) is one of the most popular and efficient techniques
in data mining. Specifically, in the clinical domain, DTs have been
wildly used thanks to relatively easy interpretation and efficient
computation time. However, some DT models may produce a large tree size
structure which is difficult to understand and often leads to
misclassification of data in the testing process. Therefore, a DT model
which is a simple tree with high accuracy is the desired goal. Post
pruning (PP) algorithms have been introduced to reduce the complexity of
the tree structure with a minor decrease in the accuracy of
classification. We propose a new Boolean satisfiability (SAT) based PP
algorithm (Namely, SAT-PP algorithm) which reduces the tree size while
preserving the accuracy of the unpruned tree, since in medical-related
tasks, decreasing the model’s performance is something we emphatically
try to avoid. Namely, in the case of medical-related tasks, one may
prefer an unpruned DT model to a pruned DT model with worse performance.
To evaluate the proposed algorithm and other PP algorithms, we compare
the performance in terms of the model query response time and accuracy
of classification using three oncology data sets. The SAT-PP DT model
obtained the same accuracy and F1 score as the DT model without PP while
significantly reducing computation time (6.8%).
Comparative Characterization and Risk Stratification of Asymptomatic and Presymptomatic Patients with COVID-19
Authors: Shi Lei , Ding Rong , Zhang Tingting , Wu Wei , Wang Ziyu , Jia Xiuzhi , Li Kening , Liang Yuan , Li Jie , Zhu Mengyan , Huang Bin , Wu Lingxiang , Wu Min , Chen Jing , Wang Chaochen , Huang Bin , Liu Caidong , Shen Hongbing , Wang Qianghu , Xia Xinyi , Li Pengping , Lyu Sali , Xiao Ying
Published: January 2024

The identification of asymptomatic, non-severe presymptomatic, and
severe presymptomatic coronavirus disease (COVID-19) in patients may
help optimize risk-stratified clinical management and improve prognosis.
This single-center case series from Wuhan Huoshenshan Hospital, China,
included 2,980 patients with COVID-19 who were hospitalized between
February 4, 2020 and April 10, 2020. Patients were diagnosed as
asymptomatic (n=39), presymptomatic (n=34), and symptomatic (n=2,907)
upon admission. This study provided an overview of asymptomatic,
presymptomatic, and symptomatic COVID-19 patients, including detection,
demographics, clinical characteristics, and outcomes. Upon admission,
there was no significant difference in clinical symptoms and CT image
between asymptomatic and presymptomatic patients for diagnosis
reference. The mean area under the receiver operating characteristic
curve (AUC) of the differential diagnosis model to discriminate
presymptomatic patients from asymptomatic patients was 0.89 (95% CI,
0.81-0.98). The severe and non-severe presymptomatic patients can be
further stratified (AUC = 0.82). The two-step risk-stratification model
based on 10 laboratory indicators on admission can facilitate early
identification of asymptomatic patients with COVID-19 and predict
illness severity for appropriate clinical management. Moreover,
single-cell data analyses revealed that the CD8+T cell exhaustion
contributed to the progression of COVID-19.
Cochlear Implants and Its Complications: A retrospective study
Authors: Christopher Vinaya Kumar Edwin , Vuppala Rakesh , Koka Rambabu , Saluja Jaswinder Pal , Suravarapu Sruthi , Ganji Srinivas , Indlamuri Srikanth
Published: January 2024

Objective: To estimate the prevalence of complications associated with
CI. Design: Retrospective descriptional study wherein data of surgeries
done during April 1994 - March 2016 was analysed. Setting: Hospital
Participants: Patients who underwent cochlear implant. Outcome measures:
Complications were recorded as surgical and non-surgical; latter were
further classified as major and minor. Results: 1236 surgeries were
performed on 933 pediatric patients (06 months-18 years) and 79 adults.
The cause of the deafness was congenital (90.91%), idiopathic (8.30%),
and meningitis (0.79%). No speech impairment was seen in eight (0.86%)
children. Bilateral profound hearing impairment was common in 99.41%
patients. In addition, Mondini’s deformity (n=05), auditory neuropathy
(n=10), adenoid hypertrophy (n=05) and tongue tie (n=10) were seen in
children. Previous CI was reported in 29.46%. Delayed milestones were
seen in 13.39%. Hypertension (14.29%) and diabetes mellitus (15.18%)
were seen in adult patients. There was history of consanguinity in
60.02% patients. Right cochlear implantation (47.43%), left (31.42%)
and Bilateral implantation (21.15%) were done. Reimplantation was
required 2.96% patients. Surgeries were performed by two surgeons,
55.34% and 41.50% surgeries respectively, and as a team (3.16%). All
pediatric patients had uneventful postoperative period. There were 17
(1.68%) complications in adults; permanent facial nerve paresis (n=04)
and flap necrosis (02) were major complications (n=08); labyrynthitis
(n=04) and wound infection (n=04) were the minor complications (n=09).
Conclusion: CI is a safe procedure for restoration of hearing loss and
the complications are within the acceptable limits.
Simultaneous and Nondestructive Diagnostics of Nitrogen/Magnesium/Potassium-deficient Cucumber Leaf Based on Chlorophyll Density Distribution Features
Authors: Shi Jiyong , Wang Yueying , Li Zhihua , Huang Xiaowei , Shen Tingting , Zou Xiaobo
Published: January 2024

Nitrogen (N), magnesium (Mg), and potassium (K) deficiency all result in
the decrease of chlorophyll density (CH.D) in cucumber leaf, but it is
difficult to differentiate N/Mg/K-deficient leaves using CH.D. New
indicators based on CH.D distribution features of cucumber leaf were
proposed to simultaneously diagnose N/Mg/K-deficient cucumber plants.
CH.D distribution map of cucumber leaves in N/Mg/K-deficient and control
groups were determined non-destructively using hyperspectral image data.
Compared with control group leaves, a decrease in CH.D could be observed
on the whole area of N-deficient leaves, Mg-deficient leaves presented
pixels with low CH.D between main leaf vein, and pixels with low CH.D
could be observed at the border of K-deficient leaves. Distribution
features were extracted from the CH.D distribution map and were employed
to diagnose N/Mg/K-deficient leaves simultaneously, with the diagnostics
rates of 96.67%. The result indicated that CH.D distribution features
have potential for simultaneous diagnosing N/Mg/K-deficient leaves in
practical applications.
Stagnation Point Propulsion of Radiative Magneto-micropolar liquid past a Heated Stretching Sheet
Authors: Warke A. S. A.S. , Katta Ramesh , Mebarek-Oudina Fateh , Abidi Awatef
Published: January 2024

In this article, we have investigated the two-dimensional MHD steady
boundary layer flow of a viscous magneto-micropolar liquid via an
extending area. The impact of heat source /sink, and chemical reaction
are considered. The governing equations are modeled in Cartesian
coordinate system. Using the suitable similarity transformations, the
partial differential equations system is changed into the nonlinear
ordinary differential equations system. The resulting system of
equations is solved through mathematical renowned software Mathematica.
The impact of diverse parameters on microrotation, concentration,
temperature and velocity are examined via graphs. The present study
reveals that, the velocity is arising function of Soret number,
Richardson number and Grashof number. It is mentioned that the greater
velocity is located in the case of Newtonian liquid as in contrast to
the micropolar liquid. In the absence of chemical reaction parameter the
velocity is more. It is physically justified that, when the chemical
reaction increases in the fluid medium, the velocity of the liquid
reduces. It is also found that radiation parameter, chemical reaction
parameter and Hartmann number augment the temperature. The current study
leads many applications in poro and magneto mechanics.
Detrended analysis for measuring the spatial correlation
Authors: Dong Keqiang , Guo Liao , Gao Xiaojie
Published: January 2024

Spatial correlation plays an important role in spatial economics.
However, there is still room for improvement of this method. We address
the question of whether the correlation may be trivial consequence of
the trends that are entirely unrelated to spatial adjacency. Application
of this analysis to selected economic data demonstrates that some trends
are not sufficient to account for spatial correlation properties. Then
we modify the spatial adjacency matrix using the detrended
cross-correlation analysis method for stock data. The modified spatial
matrix is introduced to spatial Dubin model. Application of this method
to stock data demonstrates that the spatial DCCA coefficient matrix is
an optional method.
Tropicalization of temperate reef fish communities facilitated by urchin herbivory and diversity of thermal affinities
Authors: Schuster Jasmin , Stuart-Smith Rick , Edgar Graham , Bates Amanda
Published: January 2024

Global declines in structurally complex habitats are reshaping both land
and seascapes in directions that may change how biological communities
respond to warming. Here, we test whether the widespread loss of kelp
habitats through overgrazing by sea urchins changes fish community
structure in directions that systematically alter warming sensitivity.
We use simulations and comparisons of communities from 5996 sites across
19 ecoregions to test for thermal diversity shifts related to habitat.
We find that the realized thermal affinities and ranges of fishes from
kelp and urchin barrens differ, but only in regions with high initial
response diversity. Fish communities in warm-temperate barrens host
relatively more warm-affinity species than neighbouring kelp beds,
highlighting that urchin herbivory can exacerbate tropicalization
processes. By contrast, relatively cool-affinity species colonize
cool-temperate barrens and explain apparent lags with ocean warming in
these locations. Evidently, urchins are agents of ecological change with
implications for climate resilience.
Allergy Immunotherapy: Challenges and scope for innovation
Authors: Yadav Sarika , Singh Saurabh , Mandal Payal , Gupta Shailendra , Wolkenhauer Olaf , Tripathi Anurag
Published: January 2024

Allergen specific Immunotherapy (ASIT) is the only systemic treatment
for “type I hypersensitivity”, however, undesirable minor to severe
allergic reactions are often witnessed during the course of therapy.
Moreover, there are huge variations in the sensitivity of different
patients to an allergen and the composition of allergenic extracts
available for ASIT. For a better predictability of clinical outcome in
ASIT and minimization of side effects, several combinatorial therapies
have been devised which involve administration of allergen extracts with
immunomodulatory or suppressive cytokines like TGF-β, IL-35 & IL-10.
Recently, different endogenous specialized proresolving lipid mediators
such as Lipoxins, Resolvins, Maresins and Protectins have shown promise
as therapeutic agents in the resolution of allergic inflammation.
Another growing concern is the problem of “Polyallergy”, which is
basically a sensitivity of atopic individuals to two or more allergens.
The precise diagnosis of polyallergy stands as a major challenge for
clinicians, before they can initiate ASIT methodically. In this regard,
Component Resolved Diagnosis (CRD) has emerged as a unique technological
solution for detecting polyallergy, which can replace conventional serum
specific IgE assays in near future. However, data interpretation in CRD
is bit complex and ambiguous. In this review, we have provided the
schematics of a prospective strategy, employing unique IgE epitope based
allergen fragment arrays, which can enhance the resolution and
predictability of CRD. We further suggest a technology for selecting a
subset of novel hypoallergen molecules for delivering precise and
thoroughly standardized ASIT with minimal side effects.
Modeling Control, Lockdown & Exit Strategies for COVID-19 Pandemic
Authors: Barman Madhab , Nayak Snigdhashree , Yadav Manoj , Raha Soumyendu , Mishra Nachiketa
Published: January 2024

COVID-19–a viral infectious disease–has quickly emerged as a global
pandemic infecting millions of people with a significant number of
deaths across the globe. The symptoms of this disease vary widely.
Depending on the symptoms an infected person is broadly classified into
two categories namely, asymptomatic and symptomatic. Asymptomatic
individuals display mild or no symptoms but continue to transmit the
infection to otherwise healthy individuals. This particular aspect of
asymptomatic infection poses a major obstacle in managing and
controlling the transmission of the infectious disease. In this paper,
we attempt to mathematically model the spread of COVID-19 under various
intervention strategies. The impact of various factors, such as the
presence of asymptotic individuals, lockdown strategies, social
distancing practices, quarantine, and hospitalization, on the disease
transmission is extensively studied. We consider SEIR type
epidemiological models, incorporated with social contact matrix
representing contact structures among different age groups of the
population. Numerical simulation of the model shows the dependence of
the second wave on the lockdown and its exit policies during the first
wave.
Dynamically observing the level of LYM% can Estimate the Time for SARS-CoV-2 Nucleic Acid Test results Turning Negative in COVID-19 Patients
Authors: Xiao Juan , LIU Peijun , Ding Lu , Wang Ke , Mao Chun , Guo Yabi , Zhan Yan , Yan Qiwen , Zhai Hongyu , Liu Hongqin
Published: January 2024

Until now, there are no parameter available for guiding us the proper
test scheme for COVID-19 patients during hospitalization so that the
physicians will learn their SARS-CoV-2 nucleic acid test results turning
negative timely. This study aims to explore feasible parameters to
fulfill above requirements. We collected clinical data from 69 patients
(31 SARS-CoV-2 positive pneumonia, 38 SARS-CoV-2 negative pneumonia) in
Xiangyang Central Hospital (Xiangyang, China) from Feb 12 to Feb 18,
2020 in this study. The general and laboratory data between two groups
were compared and discrepant parameters were used to assess the
correlation with viral nucleic acid test positive diagnosis. The
sensitivity of these parameters to clinical treatment and their
correlation with the nucleic acid Ct value were also analyzed. WBC,
LYM% and PLT decreased, while CRP and Hb increased significantly in
SARS-CoV-2 positive patients compared to those in common pneumonia
patients. LYM%, Hb and WBC had a good predictive ability to distinguish
the nucleic acid positive from negative pneumonia. The dynamics of WBC,
LYM%, Hb and CRP in nucleic acid positive patients were more sensitive
to clinical treatment and gradually returned to normal level. Only LYM%
had a significant correlation with Ct value. LYM% dynamics was
sensitive to clinical treatment, and significantly correlated with Ct
value, and might be feasible parameter to estimate the time for
SARS-CoV-2 nucleic acid test results turning negative.
TITLE: AN ANALYSIS OF PEDIATRIC BURN CASES IN SOUTHEASTERN ANATOLIA, TURKEY: A 10-YEAR RETROSPECTIVE STUDY
Authors: yigit ebral , yiğit yasemin demir
Published: January 2024

Abstract Background: Burns continues to be a serious global public
health problem all over the world, especially in developing countries.
Materials and Methods: The age, gender, cause of injury, total body
surface area (TBSA) of the burn, complications, and mortality rate of
1,038 patients who were hospitalized in our burn center between January
1, 2010 and January 1, 2020 were analyzed. Results: It was found that
the burned surface area in boys had a higher surface than in girls. The
TBSA was <50% and the mortality rate was 0.2% for all
patients. Hot liquids, such as tea, hot milk, hot water, and oily food,
were the causes of burns in 84.7% of the patients. Hot objects, hot
melted nylon, hot tandoor and embers, and hot asphalt accounted for
7.7% of the burns. Flame burns caused 5.6% of the burns, 1.2 %
suffered from electrical burns, frostbite and other causes of burns
caused the burns in 0.8% of the patients.. Conclusions: It was found
that pediatric burns in our region occurred more often in boys, in
children under the age of three, in children of parents with low
education levels, and in children residing in rural areas. As the
etiological factors of burn injuries vary considerably in different
communities, careful study of the pattern in every community is needed
before a sound prevention program can be planned and implemented. Hence,
this study was conducted to assess the epidemiological, causes, risk
factors, and microbial profile of burn injuries and prevention
strategies in our region. Keywords: Burns, Pediatrics, Epidemiology,
Emergency medicine, microbial profile
Targeting TRK: A Fast Tracked Application of Precision Oncology and Future Directions
Authors: Kojadinovic Arsenije , Laderian Bahar , Mundi Prabhjot
Published: January 2024

The NTRK genes encode the tropomyosin-related receptor tyrosine kinases
TrkA, TrkB and TrkC. TRK receptors play a critical role in the
development of nervous system tissues during embryogenesis and early
life. Recurrent genomic alterations in NTRK genes, typically fusions
involving the 3′ region encoding the kinase domain juxtaposed to 5′
sequences from numerous partner genes, occur at a low frequency in a
wide diversity of adult and pediatric cancers. Larotrectinib and
entrectinib are potent first-generation NTRK inhibitors with IC50 in the
nanomolar range in cellular contexts. Clinical trials of both drugs
demonstrated significant and durable responses in patients with tumors
harboring NTRK alterations, leading to first of its kind cancer agnostic
FDA approvals in the United States for drugs targeting a genomic
alteration. Unfortunately, acquired resistance inevitably develops. The
second-generation NTRK inhibitors selitrectinib and repotrectinib are
designed to overcome known mechanisms of resistance.
AN INTRODUCTION TO FUZZY TOPOLOGICAL SPACES
Authors: Zahan Ishrat , Nasrin Rehena
Published: January 2024

Topology has enormous applications on fuzzy set. An attention can be
brought to the mathematicians about these topological applications on
fuzzy set by this article. In this research, first we have classified
the fuzzy sets and topological spaces, and then we have made relation
between elements of them. For expediency, with mathematical view few
basic definitions about crisp set and fuzzy set have been recalled. Then
we have discussed about topological spaces. Finally, in the last
section, the fuzzy topological spaces which is our main object we have
developed the relation between fuzzy sets and topological spaces.
Moreover, this article has been concluded with the examination of some
of its properties and certain relationship among the closure of these
spaces.
Representation of Solutions of Nonhomogeneous Conformable Fractional Delay Differential Equations
Authors: AYDIN MUSTAFA , MAHMUDOV Nazım
Published: January 2024

This paper is about the conformable fractional delay equations. We offer
a conformable delay perturbation of matrix exponential function to give
the representation of solutions for linear nonhomogeneous conformable
fractional delay differential equations. Lastly, the existence and
uniqueness of solutions and Ulam-Hyers stability of the equations are
proved.
Preparation of battery-grade lithium carbonate with lithium-containing desorption solution
Authors: Xu Zhengguo , Sun Shu-Ying
Published: January 2024

A process for preparing battery-grade lithium carbonate with
lithium-rich solution obtained from the low lithium leaching solution of
fly ash by adsorption method was proposed. A carbonization-decomposition
process was used to remove impurities. First, primary Li2CO3 was treated
by CO2 to get the more soluble bicarbonates. The decomposition of LiHCO3
produced insoluble Li2CO3 at 90 ℃. And Li2CO3 was smashed by air stream
pulverization. The final precipitation yielded a high purity (99.6%)
and homogeneous Li2CO3. Some factors affecting the production efficiency
were investigated. The results showed that a liquid-solid ratio of 25:
1, a carbonization temperature of 25 ℃, an air velocity of 2 L/ min, and
a stirring speed of 400rpm; a decomposition temperature of 90 ℃ and a
stirring speed of 400rpm, a molar ratio of EDTA to Ca 2:1; an air
pressure of 0.3Mpa and hot water washing precipitate (L/S mass ratio
2:1) promoted ions removal.
In vitro assessment of polysaccharides immunoregulatory effects on CD3+CD56+ NKT-like cells
Authors: Lu Minghao , Huang Yaobiao , Yang Lianyang , Chen Chun
Published: January 2024

Polysaccharides have shown efficacy in a broad range of applications,
especially in immune regulation. However, there are only few effective
methods available to evaluate and compare the immunoregulatory
properties of the different polysaccharides in vitro. To screen
stringently and extend the fields of application of polysaccharide-based
treatments, a novel in vitro method, based on the use of cord
blood-derived CD3+CD56+ NKT-like cells, was developed in this study.
Four injectable polysaccharides used in clinics, including Lentinan
(LNT), Bacillus Calmette-Guerin polysaccharide nucleic acids (BCG-PSN),
ginseng polysaccharides (GPS), and Shengfu polysaccharides (SFPS), which
all might benefit cancer therapy, were further validated by testing
their effect on cell proliferation and cytotoxicity in vitro. This new
evaluation system could discriminate the effects of the four
polysaccharides. Cells treated for 4 days with either of the four
polysaccharides were fewer than untreated cells. Upon 7-day treatments,
plant- or bacteria-derived BCG-PSN, GPS, and SFPS induced higher level
of IFN-γ, proportion of cells with a CD3+CD56+ phenotype, and cytolytic
activity toward A549 cells, compared to controls. However,
fungus-derived LNT yielded lower IFN-γ, proportion of CD3+CD56+ cells,
and cytolytic activity than control conditions. Conclusively, cord
blood-derived CD3+CD56+ NKT-like cells may represent a powerful tool to
screen and evaluate the immunoregulatory potential of biological or
chemical compounds for clinical developments and applications.
THE RELATIONSHIP BETWEEN ANTI-CCP POSITIVITY AND CLINICAL/RADIOLOGICAL FINDINGS IN PATIENTS WITH PSORIATIC ARTHRITIS
Authors: Isik Ozlem Ozdemir , Cosan Fulya , Yazici Ayten , Cefle Ayse
Published: January 2024

Psoriatic arthritis (PsA) is a chronic inflammatory disease in the
spondyloarthropathy group with the history of psoriasis. Although some
PsA findings are similar to rheumatoid arthritis (RA), rheumatoid factor
negativity, some radiological and clinical findings are different in
PsA. There is no spesific laboratory examination for diagnosis of PsA.
On the other hand, anti-CCP antibody positivity is a spesific finding
for the diagnosis of RA. Objectives: We aimed in this study to analyse
the frequency of anti-CCP positivity in PsA and the association with
clinical and radiological findings. Methods: The study group is
consisted of 100 PsA patients, who fulfilled the CASPAR cirteria for PsA
and 100 healthy controls (HC). We filled a form for all patients, which
included clinical and laboratory findings of patients. We analyzed
anti-CCP antibody with micro ELISA in the sera of patients. Results: In
our study, the anti-CCP positivity was detected in 15% of PsA group and
4% of healthy controls. The difference was statistically significant
(p=0,014; OR=4.24, 95% CI=1.35–13.25). Nine out of 15 anti-CCP
positive patients were female, the remaining 6 were male. Thirteen
patients (86,7%) had peripheral arthritis, 1 patient (6,7%)had
sacroiliitis, 1 patient (6,7%) had peripheral arthritis and
sacroiliitis. 42,8% of PsA patients with peripheral arthritis had
asymetric olygoarthritis (6/14), 28,5% had monoarthritis (4/14) and
28,5% had symetric polyarthritis (4/14). Anti-CCP antibody positivity
had no effect on the involvement of peripheral arthritis. Sacroiliitis
and dactilitis were more frequent in the anti-CCP negative group. No
patient with dactylitis had anti-CCP positivity (p=0.005). While, 43,5%
of RF positive patients were detected anti-CCP positivity, 6,5% of RF
negative patients were detected anti-CCP positivity (p=0,000).
Conclusions: Our data reveals that anti-CCP positivity is more frequent
in PsA compared to HC. We found no statisticall association between
anti-CCP positivity and clinical or radiological findings
Still no clarity on parity: A survey accessing interpretation of the word parity amongst obstetricians and midwives and a literature review.
Authors: Maraj Hemant , Kumari Sujatha
Published: January 2024

Objectives: We assessed clinical interpretation of the word parity
amongst obstetricians and midwives in Wales and performed a literature
review to identify a standardised definition. Design: A survey was
conducted by electronic questionnaire followed by a literature review
using dictionaries, standard texts, professional bodies and websites.
Setting: Obstetricians across Wales and midwives across North Wales.
References were obtained for the UK, USA, India, Malaysia and West
Indies. Methods: The questionnaire was distributed to obstetricians
using the Wales Information System. Midwives were surveyed using a
health board wide distribution list. Results: There were 143 responses
from 63 doctors and 80 midwives. 5% of doctors and 49% of midwives did
not include stillbirths after 24 completed weeks in their definition of
parity. 84% of all surveyed described having a previous twin delivery
as Para 2. 23 references were obtained for a definition of parity.
Parity was variability defined as the number of conceptions,
pregnancies, births, and babies. Only 12 sources offered a definition in
reference to multiple pregnancy. Of these, 8 sources defined multiple
births as a single parous event. Conclusions: There are variations in
definitions for the term parity from referenced sources and variation in
understanding amongst staff surveyed. We recommend UK professional
bodies take into consideration the findings of this study and provide a
standard consensus definition of parity.
Analysis of Opsin Gene Family of Crimson Snapper (Lutjanus erythropterus)
Authors: liang qiulu , Afriyie Gyamfua , Cheng Zizhao , Xu Zhenmin , Du Juan , Huang Jiahui , Dong Zhongdian , Wang Zhongduo , Guo Yusong
Published: January 2024

Opsin is a fellow of the G protein-coupled receptors (GPCRs)
superfamily. It can be divided into visual and non-visual opsins
according to whether they are directly involved in visual imaging. Opsin
plays an important role in visual image formation and the regulation of
non-image forming functions such as circadian entrainment in the growth,
development and evolution of fish. Crimson snapper is mainly found in
the Indo-West Pacific and the southern part of the East China Sea and
the South China Sea. It is one of the most influential economic fish in
the South China Sea. In order to study the existence and expression of
opsin gene in Crimson snapper, we sequenced the genome and tissue sample
transcriptome of Crimson snapper. In this study, 32 opsin genes were
identified from the genome with the length of 1061 bp - 86203 bp
distributed on 15 different chromosomes. The analysis of opsin gene
family of Crimson snapper showed that the sws2 was expanded with two
copies than that of Zebrafish. Domain and motif analysis revealed that
all the 32 opsin sequences had 7TM receptors, and Crimson snapper opsin
family contained 10 common motifs. The expression level of opsin gene,
confirmed by RT-qPCR, was analyzed by using nine tissues transcriptome
databases of Crimson snapper. The results showed that almost opsin genes
were highly expressed in the retina and brain,except opn7a and opn7b
which were expressed in intestine and red skin, and almost no expression
in other tissues.
Analysis of the determining factors of detectable P-wave and amplitude of QRS complex sensed by implantable loop recorder
Authors: Ahn Jang Ho , Ryu Hyunho , OH IL-YOUNG , Cho Youngjin , Lee Ji Hyun
Published: January 2024

Introduction – Determining factors for sufficient QRS amplitude and
discernible P-wave sensing in ILR are unknown. We aimed to investigate
determining factors and ILR implantation angle that may improve QRS
complex and P-wave sensing in ILR. Methods and Results – We
retrospectively reviewed 220 patients who underwent ILR implantation or
follow-up analysis. Patient demographic, clinical, echocardiography,
electrocardiography, heart angle, and ILR angle data were collected as
predictor variables. Associations between ILR QRS amplitude/P-wave
detectability and each predictor variable were investigated. Univariate
linear regression showed that ILR QRS amplitude was significantly
associated with age, height, ILR angle, and QRS amplitudes of 12-Lead
ECG [lead I, II, -aVR (inverted aVR), aVF, V1-V6] and Holter ECG
(lead V3, V5). Among discrete variables, only left ventricular
hypertrophy (LVH) affected ILR QRS amplitude (P=0.016). A multivariate
linear regression analysis revealed that ILR angle (β= -0.008,
P<0.001), lead -aVR amplitude (β=0.469, P=0.003), Holter lead
V5 amplitude (β=0.116, p=0.049), Age (β=-0.005, P=0.014), and LVH
(β=0.213, P= 0.031) were independent determinants of ILR QRS amplitude.
Logistic regression revealed that heart angle significantly affected ILR
P-wave detectability (β=0.12, P=0.008). Multiple logistic regression
revealed that heart angle (β=0.121, P= 0.013) and lead V1 amplitude
(β=28.1, P= 0.034) were independent determinants of ILR P-wave
detectability. Conclusion – ILR insertion angle, lead -aVR QRS
amplitude, Holter lead V5 QRS amplitude, age, and LVH are determinants
of ILR QRS amplitude. Heart angle and lead V1 P-wave amplitude of
12-Lead ECG are determinants of ILR P-wave detectability.
Acute Bartholin’s Gland Abscess Treatment by Simple Needle Aspiration: A Prospective Cohort Study
Authors: Charavil Axelle , MIQUEL Laura , Tourette Claire , Pivano Audrey , Castel Pierre , Crochet Patrice , Agostini Aubert
Published: January 2024

Objective: To examine the success rate of simple needle aspiration (SNA)
for acute Bartholin’s gland abscess (ABGA). Design: Prospective cohort
study. Setting: Academic Hospital of La Conception, Marseille, France.
Population or Sample: Women who presented with AGBA between June 2013
and October 2017. Methods: The study cohort was subdivided into two
treatment groups, SNA or incision and drainage (ID), according to their
preference. Success was considered the absence of surgical treatment
(failure treatment) within one month of the initial treatment.
Recurrence was considered the occurrence of a new ABGA requiring
surgical treatment (recurrence treatment) between one and 12 months
after the initial treatment. Main Outcome Measures: Rate of women
without failure or recurrence treatment after SNA. Comparison of success
and recurrence rates between SNA and ID treatment for ABGA. Results: The
rate of women without failure or recurrence treatment after SNA was
68/134 (51% (95% CI: 42-59%)). The success rate was lower in the SNA
group than in the ID group: 93/134 (69%) versus 38/42 (90%) (relative
risk [RR]: 0.77, 95% confidence interval [CI]: 0.66-0.89, p
< 0.05). The rate of women without failure or recurrence
treatment was similar in the SNA and ID group, respectively: 68/134
(51%) versus 25/42 (60%) (RR: 0.85, 95% CI: 0.63-1.15, p = 0.3).
Conclusions: SNA can be offered as first-line treatment for ABGA. SNA
can be performed as an outpatient procedure without anaesthesia and
remove the need for secondary surgery in half of the cases one year
post-treatment surgery.
Pathogen spectrum changes of respiratory tract infections in children in Chaoshan area under the influence of COVID-19
Authors: Lin Chuang-xing , Lian Hao-bin , Lin Guang-Yu , Zhang Dan-gui , Cai Xiao-Ying , Cai Zhi-Wei , Wen Fei-qiu
Published: January 2024

Abstract Background: From January 24, 2020 to May 18, 2020, Chaoshan
took measures to limit the spread of COVID-19, such as restricting
public gatherings, wearing masks, and suspending classes. This study
explored the effects of these measures on the pathogen spectrum of
children in the Chaoshan area. Methods: Pharyngeal swab samples were
collected from children hospitalized for respiratory tract infection. We
used liquid chip technology to analyze 14 respiratory pathogens. Data
were used to explore group differences, age related differences and
seasonal variations in respiratory pathogens. Results: The study
included 4075 children. The number of cases in the outbreak group (1222)
was 42.8% of that in the pre-outbreak group (2853). The virus-detection
rate was similar in the outbreak (48.3%, 590/1222) and pre-outbreak
groups (51.5%, 1468/2853; χ2 = 3.446, P = 0.065), while the
bacteria-detection rate was significantly lower in the outbreak group
(26.2%, 320/1222) than in the pre-outbreak group (44.1%, 1258/2853; χ2
= 115.621, P < 0.05). With increase in age, the proportions of
RSV and CMV infections gradually decreased, while those of MP, SP, and
Adenovirus infections increased. SP, CMV, and Rhinovirus infections
peaked in autumn and winter, while RSV infections peaked in summer and
winter. Conclusion: Anti-COVID-19 measures significantly reduced the
number of children hospitalized for respiratory tract infections,
significantly altered the pathogen spectrum of respiratory tract
infections, and decreased the overall detection rates of 14 common
respiratory pathogens. The proportion of bacterial infections decreased,
but that of viral infections did not.
A case report on SARS-CoV2 induced croup
Authors: Tsoi Kathleen , Chan Kate , Chan Chi Ngong Lawrence , Mok Geoffrey , Li Albert , Lam Hugh
Published: January 2024

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection
usually causes no or mild coryzal symptoms in the paediatric population.
In this case report, we describe a 21-month-old boy infected with
SARS-CoV-2 who presented atypically with features compatible with croup.
With the current Coronavirus Disease 2019 (COVID-19) pandemic, infection
control measures need to be appropriately heightened and early
diagnostic sampling for SARS-CoV-2 should be carried out even in
symptomatology that is atypical of COVID-19.