bluuebunny/crossref_metadata_2025 huggingface dataset:
Scoping review of the characteristics assessed by vulnerability indices applied to people experiencing homelessness
Authors: Currie Jane , Grech Elizabeth , Longbottom Erin , Yee Jasmine , Hastings Ruth , Aitkenhead Amy , Cason Amy , Obrecht Karin
Published: July 2021

Background

The objectives of this scoping review are to investigate the characteristics assessed by existing vulnerability indices and the health outcomes achieved by applying them to people experiencing homelessness. This review forms part of the development and implementation of a novel tool to prioritise people experiencing homelessness for healthcare based on their need and capacity to access healthcare.

Methods

Included papers were primary research, published in the English language, participants were experiencing homelessness and aged over 18 years at the time of the study, a vulnerability index was used in the study, sample size was greater than 30, and the study had a health focus. Databases searched were MEDLINE, Embase, CINAHL, Scopus, PubMed and Web of Science, between January-April 2020. The Joanna Briggs Appraisal criteria were used to quality appraise the included studies. Results were synthesised narratively.

Results

Six papers were included, a total of 27,509 participants. The reported use of the indices varied; they included screening and profiling homeless populations, comparing homeless populations, and two studies evaluated the predictive capacity, reliability and validity of the indices. One vulnerability index focused on screening for human immunodeficiency virus, one used a 50-item index and four used a nine-item index. No direct health outcomes were reported from applying the vulnerability indices. The studies identified limitations of using vulnerability indices, including the potential bias of relying on self-reported data and two studies highlighted the need for further psychometric testing to ensure validity and reliability of the indices.

Discussion

The sample of included studies was small. Vulnerability indices are reportedly a useful and easily accessible method of gaining valuable data on the health status and health needs of people experiencing homelessness. The variety of characteristics included in the vulnerability indices suggests the importance of tailoring vulnerability indices to the needs of the population to which it is to be applied. Conducting appropriate psychometric testing is critical so that an index can be used to accurately inform decision making and accurately prioritise people experiencing homelessness who are most at risk of mortality and morbidity. A specific tool that prioritises people experiencing homelessness for access to health care is not yet available. The review was funded by a St Vincent’s Network Inclusive Health grant.
Genome-wide identification of the MIOX gene family and their expression profile in cotton development and response to abiotic stress
Authors: Li Zhaoguo , Liu Zhen , Wei Yangyang , Liu Yuling , Xing Linxue , Liu Mengjie , Li Pengtao , Lu Quanwei , Peng Renhai
Published: July 2021

The enzyme myo-inositol oxygenase (MIOX) catalyzes the myo-inositol into glucuronic acid. In this study, 6 MIOX genes were identified from all of the three diploid cotton species (Gossypium arboretum, Gossypium herbaceum and Gossypium raimondii) and Gossypioides kirkii, 12 MIOX genes were identified from two domesticated tetraploid cottons Gossypium hirsutum, Gossypium barbadense, and 11 MIOX genes were identified from three wild tetraploid cottons Gossypium tomentosum, Gossypium mustelinum and Gossypium darwinii. The number of MIOX genes in tetraploid cotton genome is roughly twice that of diploid cotton genome. Members of MIOX family were classified into six groups based on the phylogenetic analysis. Integrated analysis of collinearity events and chromosome locations suggested that both whole genome duplication and segmental duplication events contributed to the expansion of MIOX genes during cotton evolution. The ratios of non-synonymous (Ka) and synonymous (Ks) substitution rates revealed that purifying selection was the main force driving the evolution of MIOX genes. Numerous cis-acting elements related to light responsive element, defense and stress responsive element were identified in the promoter of the MIOX genes. Expression analyses of MIOX genes based on RNA-seq data and quantitative real time PCR showed that MIOX genes within the same group shared similar expression patterns with each other. All of these results provide the foundation for further study of the biological functions of MIOX genes in cotton environmental adaptability.
Effects of interventions for social anxiety and shyness in school-aged children: A systematic review and meta-analysis
Authors: Cordier Reinie , Speyer Renée , Mahoney Natasha , Arnesen Anne , Mjelve Liv Heidi , Nyborg Geir
Published: July 2021

In school, shyness is associated with psychosocial difficulties and has negative impacts on children’s academic performance and wellbeing. Even though there are different strategies and interventions to help children deal with shyness, there is currently no comprehensive systematic review of available interventions. This systematic review and meta-analysis aim to identify interventions for shy children and to evaluate the effectiveness in reducing psychosocial difficulties and other impacts. The methodology and reporting were guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement and checklist. A total of 4,864 studies were identified and 25 of these met the inclusion criteria. These studies employed interventions that were directed at school-aged children between six and twelve years of age and described both pre- and post-intervention measurement in target populations of at least five children. Most studies included an intervention undertaken in a school setting. The meta-analysis revealed interventions showing a large effect in reducing negative consequences of shyness, which is consistent with extant literature regarding shyness in school, suggesting school-age as an ideal developmental stage to target shyness. None of the interventions were delivered in a classroom setting, limiting the ability to make comparisons between in-class interventions and those delivered outside the classroom, but highlighting the effectiveness of interventions outside the classroom. The interventions were often conducted in group sessions, based at the school, and involved activities such as play, modelling and reinforcement and clinical methods such as social skills training, psychoeducation, and exposure. Traditionally, such methods have been confined to a clinic setting. The results of the current study show that, when such methods are used in a school-based setting and involve peers, the results can be effective in reducing negative effects of shyness. This is consistent with recommendations that interventions be age-appropriate, consider social development and utilise wide, school-based programs that address all students.
Analysis of individual differences in pelvic and spine alignment in seated posture and impact on the seatbelt kinematics using human body model
Authors: Nishida Norihiro , Izumiyama Tomohiro , Asahi Ryusuke , Jiang Fei , Ohgi Junji , Yamagata Hiroki , Imajo Yasuaki , Suzuki Hidenori , Funaba Masahiro , Sugimoto Shigeru , Fukushima Masanobu , Chen Xian , Sakai Takashi
Published: July 2021

Analysis using human body models has been performed to reduce the impact of accidents; however, no analysis has shown a relationship between lumbar and pelvic/spine angle and seat belts in reducing human damage from accidents. Lumbar and pelvic/spine angles were measured in 75 individuals and the measurements were used to create three different angles for the Total Human Model for Safety model. In the present study, we focused on lumber lordosis (LL) and pelvic angle (PA). A normal distribution and histogram were used for analysis of PA (01, 10, and 50). The Total Human Model for Safety, including LL and PA, was corrected using finite element software. Simulations were conducted under the conditions of the Japan New Car Assessment Programme (JNCAP) 56 kph full lap frontal impact. Using the results of the FEM, the amount of lap-belt cranial sliding-up, anterior movement of the pelvis, posterior tilt of the pelvis, head injury criterion (HIC), second cervical vertebrae (C2) compressive load, C2 moment, chest deflectiou (upper, middle, and lower), left and right femur load, and shoulder belt force were measured. The lap-belt cranial sliding-up was 1.91 and 2.37 for PA10 and PA01, respectively, compared to PA50; the anterior movement of the pelvis was 1.08 and 1.12 for PA10 and PA01, respectively; and the posterior tilt of the pelvis was 1.1 and 1.18 for PA10 and PA01, respectively. HIC was 1.13 for PA10 and 1.58 for PA01; there was no difference in C2 compressive load by PA, but C2 moment increased to 1.59 for PA10 and 2.72 for PA01. It was found that as LL increases and the PA decreases, the seat belt becomes likely to catch the iliac bone, making it harder to cause injury. This study could help to reconsider the safe seat and seatbelt position in the future.
Tooth wear development in the Australian Aboriginal dentition from Yuendumu: A longitudinal study
Authors: Lee Jinyoung , Fung Sarah , Yong Robin , Ranjitkar Sarbin , Kaidonis John , Evans Alistair R. , Fiorenza Luca
Published: July 2021

The analysis of dental wear, at both the microscopic and macroscopic scale, is one of the most widely used tools in archeology and anthropology to reconstruct the diet and lifestyle of past human populations. Biomechanical studies have indicated that tooth wear helps to dissipate the mechanical load over the crown surface, thus reducing the risk of tooth fracture. To date, there are only a few studies that have examined functional tooth wear variation in modern humans. Here we propose to study masticatory efficiency through the use of the Occlusal Fingerprint Analysis method, a well-developed digital approach that allows the reconstruction of the occlusal dynamics occurring during mastication. The aim of this study is to provide the first longitudinal quantitative data of molar and premolar macrowear patterns within a functional context. We examined the mixed and permanent dentition of one Australian Aboriginal child (from ages 8 to 17) from Yuendumu, using high-resolution surface scans of dental casts including both upper and lower arches. Our results suggest that the occlusal macrowear patterns of this individual did not significantly change through time. Occlusal contact parameters such as functional area, inclination and direction remain relatively unaltered throughout childhood and adolescence, indicating little change in the masticatory function of this individual. The functional tooth wear pattern in this individual did not change longitudinally indicating the degree of masticatory efficiency has most probably remained unaltered.
Development and analytical validation of a novel bioavailable 25-hydroxyvitamin D assay
Authors: Berg Anders H. , Tavasoli Mahtab , Lo Agnes S. , Burnett-Bowie Sherri-Ann M. , Bhan Ishir , Karumanchi S. Ananth , Kalim Sahir , Zhang Dongsheng , Zhao Sophia , Thadhani Ravi I.
Published: July 2021

Background

Bioavailable 25-hydroxyvitamin D (25OHD) may be a better indicator of vitamin D sufficiency than total 25OHD. This report describes a novel assay for measuring serum bioavailable 25OHD.

Methods

We developed an assay for 25OHD % bioavailability based on competitive binding of 25OHD tracer between vitamin D-binding protein (DBP)-coated affinity chromatography beads and serum DBP. Bioavailable 25OHD, total 25OHD, albumin, and DBP protein concentrations were measured in 89 samples from hospitalized patients and 42 healthy controls to determine how the DBP binding assay responds to differences in concentrations of DBP and compares to calculated bioavailable 25OHD values.

Results

DBP binding assay showed a linear relationship between DBP-bound 25OHD tracer recovered from bead supernatant and DBP calibrator concentrations (y = 0.0017x +0.731, R2 = 0.9961, p<0.001). Inversion of this relationship allowed interpolation of DBP binding equivalents based upon 25OHD tracer recovered. The relationship between DBP binding equivalents and % bioavailability fits a non-linear curve, allowing calculation of % bioavailable 25OHD from DBP binding equivalents (y = 10.625x-0.817, R2 = 0.9961, p<0.001). In hospitalized patient samples, there were linear relationships between DBP protein concentrations and DBP binding equivalents (y = 0.7905x + 59.82, R2 = 0.8597, p<0.001), between measured vs. calculated % bioavailability (y = 0.9528 + 0.0357, R2 = 0.7200, p<0.001), and between absolute concentrations of measured vs. calculated bioavailable 25OHD (y = 1.2403 + 0.1221, R2 = 0.8913, p<0.001).

Conclusions

The DBP-binding assay for bioavailable 25OHD shows expected changes in 25OHD % bioavailability in response to changes in DBP concentrations and concordance with calculated bioavailable 25OHD concentrations.
Predicting binge drinking among university students: Application of integrated behavioral model
Authors: Gutema Hordofa , Debela Yamrot , Walle Bizuayehu , Reba Kidist , Shibabaw Tebkew , Disasa Tolera
Published: July 2021

Background

Binge drinking is a pattern of harmful use of alcohol and it is defined as four drinks for women and five drinks for men in about 2 hours. This behavior causes public health problems like damaging different body organs.

Objective

To assess binge drinking and associated factors among Bahir Dar University students in Northwest Ethiopia.

Method

A cross sectional study was conducted in November 2017. Systematic sampling technique was used to select 422 participants. Structured questionnaire was used to collect data. Linear and Logistic regression models were used to predict the role of explanatory variables on behavioral intention and binge drinking, respectively. Independent variables with a p-value of <0.05 at 95% confidence interval were considered as statistically significant in the final model.

Result

A total of 413 students participated in this study and 33.4%(95% CI: 28.3–38.9) were engaged in binge drinking. Experiential attitude, instrumental attitude, and self-efficacy were found to be significant predictors of intention to binge drinking (p<0.05). Experiential attitude, environmental constraint, injunctive norm, and knowledge predictors were significantly associated with binge drinking (p<0.05).

Conclusion

Our study indicated that one-third of the students practiced binge drinking. This behavior was associated with experiential attitude, injunctive norm, environmental constraints, and knowledge factors. Additionally, experiential attitude, instrumental attitude, and self-efficacy constructs had explained behavioral intention. This implies focusing on the abovementioned determinant factors is imperative while designing intervention strategy.
A systematic review of controlled studies of suicidal and self-harming behaviours in adolescents following bereavement by suicide
Authors: del Carpio Laura , Paul Sally , Paterson Abigail , Rasmussen Susan
Published: July 2021

Background

Research suggests that being exposed to the suicide of others increases risk of subsequent suicidal or self-harming thoughts or behaviours. What is less clear is whether this applies to adolescents, and if the risk exceeds that following other causes of death, which has implications on suicide prevention approaches. This study aimed to systematically review the evidence on adolescent bereavement experiences by different causes to address this gap.

Methods

A comprehensive literature search using four databases (MEDLINE, PsycInfo, Web of Science, and Embase) identified 21 studies which measured suicidal or self-harm outcomes among bereaved adolescents aged between 12 to 18 years old. The literature was screened, data was extracted using pre-piloted forms, and risk of bias was assessed using versions of the Newcastle-Ottawa Scale; a proportion of papers were double extracted and assessed for bias. The review has been registered with PROSPERO (CRD42016051125).

Results

A narrative synthesis of the literature demonstrated divergent findings depending on the outcome being measured. Suicide bereavement appears to be strongly associated with suicide mortality among parentally bereaved youth, while self-harm or non-fatal suicide attempts (either presenting to hospital or self-reported) showed mixed evidence. Suicidal ideation was not uniquely associated with suicide bereavement. An exploration of circumstances surrounding the death, characteristics of the person who died, and characteristics of the young person across each outcome measure suggested that earlier experiences of loss, shorter timeframes following the death, and maternal death are associated with particularly elevated risk of suicidal outcomes.

Conclusions

Findings suggest that suicide loss is associated with subsequent suicide, and may be associated with non-fatal self-harm. A detailed account of the risk and protective factors surrounding suicide bereavement among young people is crucial to understand the pathways through which suicidal behaviours develop. Researchers, policy makers and practitioners with an interest in suicide prevention will benefit from clarity around the needs of young bereaved individuals.
Effectiveness of a standard clinical training program in new graduate nurses’ competencies in Vietnam: A quasi-experimental longitudinal study with a difference-in-differences design
Authors: Horii Satoko , Nguyen Chinh Thi Minh , Pham Huong Thi Thu , Amaike Naomi , Ho Hien Thi , Aiga Hirotsugu
Published: July 2021

Objective

This study aimed to estimate the effectiveness of a standard clinical training program for new graduate nurses in Vietnam.

Methods

A quasi-experimental longitudinal study with a difference-in-differences design was conducted. A total of 280 new graduate nurses completed a self-administered questionnaire. The intervention group consisted of 206 respondents (those having participated in standard clinical training) and the control group (those that did not receive training) of 74. Differences in mean increases in competency scores between the intervention and control groups were estimated. The effect size of the intervention was estimated by calculating Cohen’s d. A generalized linear model was employed to identify the factors associated with mean increases.

Results

The mean increase in total competency scores (range: 0–6 points) in the intervention group was 0.73 points greater than in the control group with an intermediate effect size (Cohen’s d = 0.53; 95% CI 0.26 to 0.80). A greater reduction in standard deviation of total competency scores in the intervention group was confirmed. Participation in standard clinical training produced a positive association with a mean increase in total competency score without significance (β = 0.04, P = 0.321). Provincial hospitals as clinical training venues had a significantly positive association (β = 0.11, P = 0.007) with the mean increase in total competency scores. Competency at pre-clinical training was negatively (β = -0.75, P < 0.001) associated with the mean increase.

Conclusion

Findings implied that the standard clinical training program could contribute to both increasing and standardizing new graduate nurses’ competencies in Vietnam. Further studies are needed to more precisely examine the attribution of standard clinical training to better increase new graduate nurses’ competencies.
Partial restoration of immune response in Hepatitis C patients after viral clearance by direct-acting antiviral therapy
Authors: Llorens-Revull Meritxell , Costafreda Maria Isabel , Rico Angie , Guerrero-Murillo Mercedes , Soria Maria Eugenia , Píriz-Ruzo Sofía , Vargas-Accarino Elena , Gabriel-Medina Pablo , Rodríguez-Frías Francisco , Riveiro-Barciela Mar , Perales Celia , Quer Josep , Sauleda Silvia , Esteban Juan Ignacio , Bes Marta
Published: July 2021

Background & aims

HCV CD4+ and CD8+ specific T cells responses are functionally impaired during chronic hepatitis C infection. DAAs therapies eradicate HCV infection in more than 95% of treated patients. However, the impact of HCV elimination on immune responses remain controversial. Here, we aimed to investigate whether HCV cure by DAAs could reverse the impaired immune response to HCV.

Methods

We analyzed 27 chronic HCV infected patients undergoing DAA treatment in tertiary care hospital, and we determined the phenotypical and functional changes in both HCV CD8+ and CD4+ specific T-cells before and after viral clearance. PD-1, TIM-3 and LAG-3 cell-surface expression was assessed by flow cytometry to determine CD4+ T cell exhaustion. Functional responses to HCV were analyzed by IFN-Ɣ ELISPOT, intracellular cytokine staining (IL-2 and IFN-Ɣ) and CFSE-based proliferation assays.

Results

We observed a significant decrease in the expression of PD-1 in CD4+ T-cells after 12 weeks of viral clearance in non-cirrhotic patients (p = 0.033) and in treatment-naive patients (p = 0.010), indicating a partial CD4 phenotype restoration. IFN-Ɣ and IL-2 cytokines production by HCV-specific CD4+ and CD8+ T cells remained impaired upon HCV eradication. Finally, a significant increase of the proliferation capacity of both HCV CD4+ and CD8+ specific T-cells was observed after HCV elimination by DAAs therapies.

Conclusions

Our results show that in chronically infected patients HCV elimination by DAA treatment lead to partial reversion of CD4+ T cell exhaustion. Moreover, proliferative capacity of HCV-specific CD4+ and CD8+ T cells is recovered after DAA’s therapies.
Healthcare worker’s emotions, perceived stressors and coping mechanisms during the COVID-19 pandemic
Authors: Rose Suzanne , Hartnett Josette , Pillai Seema
Published: July 2021

Increasing cases, insufficient amount of personal protection equipment, extremely demanding workloads, and lack of adequate therapies to save lives can contribute to a psychological burden directly related to working during disease outbreaks. Healthcare workers (HCWs) are at a high risk of contracting COVID-19 due to its ability to spread efficiently through asymptomatic and symptomatic individuals. There are limited studies assessing the pandemic’s psychological impact on HCWs, specifically those in close proximity to hospitalized patients with COVID-19. Our study explored the emotions, perceived stressors, and coping strategies of front-line HCWs at high risk of exposure to COVID-19 during the first surge at our community-based teaching hospital, the epicenter of COVID-19 in Connecticut. A validated comprehensive questionnaire derived and modified from previous epidemics was used to inquire about staff feelings, factors that caused stress and factors that mitigated stress. Personal coping strategies and factors that can increase staff’s motivation to work during future events of similar nature were also asked. Emotional reactions, coping mechanisms, and stressors varied by healthcare role, while some experiences and reactions were similar among groups. Willingness to participate in a second wave of the pandemic or future outbreaks is strongly driven by adequate personal protective equipment, financial recognition, and recognition from management, similarly reported in previous disease outbreaks. All groups felt a reduction in stress due to a sense of camaraderie and teamwork, as well as when sharing jokes or humor with colleagues. Our HCWs at high risk of exposure experienced significant emotional distress during the first wave of the COVID-19 pandemic. By understanding the needs and experiences of our HCWs at highest risk, we can improve our psychological support using targeted interventions during future waves of this pandemic or similar devastating events.
Screen time and physical activity in children and adolescents aged 10–15 years
Authors: Dahlgren Anna , Sjöblom Linnea , Eke Helén , Bonn Stephanie E. , Trolle Lagerros Ylva
Published: July 2021

Background

Previous research studies have demonstrated a relationship between low levels of physical activity and high amounts of screen time in children and adolescents. However, this is usually based on self-reported data. Therefore, the aim of this cross-sectional study was to investigate the association between objectively measured smartphone screen time and physical activity among children and adolescents aged 10–15 years.

Methods

During seven consecutive days, we objectively assessed smartphone screen time, using the SCRIIN smartphone application, and physical activity, using the SCRIIN activity tracker, in children and adolescents recruited from two schools in Stockholm County, Sweden. Moreover, the children/adolescents and their parents responded to a questionnaire, obtaining among other things: self-reported screen time, physical activity, sleep and health-related quality of life.

Results

A total of 121 children and adolescents (mean age: 12.1 ± 1.5) were included in the study. Objectively measured smartphone screen time was 161.2 ± 81.1 min/day. Mean physical activity, measured with the SCRIIN activity tracker, was 32.6 ± 16.5 active min/day. Minutes of screen time and physical activity did not differ between the children and adolescents from the two schools, despite located in different socioeconomic areas. Further, we found no association between smartphone screen time and physical activity. However, girls aged 14–15 years, had more smartphone screen time (p<0.01) and were significantly more physically active (p<0.01) than girls aged 10–12 years. In addition, boys reported more than five times more time spent on computer and video games than girls did.

Conclusion

Smartphone screen time was not associated with physical activity level among children and adolescents aged 10–15 years.
Micro-computed tomography with contrast enhancement: An excellent technique for soft tissue examination in humans
Authors: O. Jehoon , Kwon Hyun-Jin , Cho Tae-Hyeon , Woo Seung Hoon , Rhee Yun-Hee , Yang Hun-Mu
Published: July 2021

Manual dissection and histologic examination are commonly used to investigate human structures, but there are limitations in the damage caused to delicate structures or the provision of limited information. Micro-computed tomography (microCT) enables a three-dimensional volume-rendered observation of the sample without destruction and deformation, but it can only visualize hard tissues in general. Therefore, contrast-enhancing agents are needed to help in visualizing soft tissue. This study aimed to introduce microCT with phosphotungstic acid preparation (PTA-microCT) by applying the method to different types of human tissue. Specimens from human cadavers were used to examine the orbicularis retaining ligament (ORL), nasolabial fold (NLF), and the calcaneal tunnel of the sole. Using PTA-microCT, relevant information of human structures was identified. In the ORL study, tiny and delicate ligamentous fibers were visualized in detail with multidirectional continuity. In the NLF study, complex structural formation consisting of various types of soft tissue were investigated comprehensively. In the calcaneal tunnel study, the space surrounded by diverse features and its inner vulnerable structures were examined without damage. Consequently, we successfully applied the PTA-microCT technique to the analysis of specific human soft tissue structures that are challenging to analyze by conventional methods.
The methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism is associated with breast cancer subtype susceptibility in southwestern China
Authors: Li Zhen , Zhang Ji , Zou Wei , Xu Qi , Li Siyuan , Wu Jie , Zhu Li , Zhang Yunjiao , Xu Lei , Zhang Ying , Luo Qingsong , Nie Jianyun , Li Xingxu , Zou Tianning , Chen Ceshi
Published: July 2021

Methylenetetrahydrofolate reductase (MTHFR), a folate-dependent enzyme, is reportedly involved in several cancer types. The MTHFR C677T polymorphism influences many biological processes, including tumorigenesis. However, the association between the MTHFR C677T polymorphism and breast cancer (BC) subtypes is not fully understood. In this study, the MTHFR C677T polymorphism was genotyped in 490 individuals with or without BC from southwestern China. Analysis of the association between the MTHFR C677T polymorphism and BC revealed that there was a significant association between the MTHFR C677T polymorphism and triple-negative breast cancer (TNBC) (OR = 2.83, 95% CI: 1.12–9.51, P = 0.0401). Furthermore, the MTHFR C677T polymorphism can also serve as a protective factor in luminal A breast cancer (OR = 0.57, 95% CI: 0.34–0.94, P = 0.0258). Evaluation of the association between the MTHFR C677T polymorphism and clinical characteristics indicated that people who suffered from hypertension had an increased risk for BC (OR = 2.27; 95% CI: 1.08–4.6; P = 0.0264), especially TNBC (OR = 215.38; 95% CI: 2.45–84430.3; P = 0.0317). Our results suggest that the MTHFR C677T polymorphism is significantly associated with susceptibility to luminal B breast cancer and TNBC.
The consequences of chaos: Foraging activity of a marine predator remains impacted several days after the end of a storm
Authors: Barreau Emmanuelle , Kato Akiko , Chiaradia Andre , Ropert-Coudert Yan
Published: July 2021

As extreme weather is expected to become more frequent with global climate change, it is crucial to evaluate the capacity of species to respond to short-term and unpredictable events. Here, we examined the effect of a strong storm event during the chick-rearing stage of little penguins (Eudyptula minor) from a mega colony in southern Australia. We investigated how a 3-day storm affected the foraging behaviour of little penguins by comparing their foraging activities and body mass change before, during and after the storm event. As strong winds deepened the mixed layer in the birds’ foraging zone during the storm, penguins increased their foraging trip duration, had a lower prey encounter rate and a lower body mass gain. The adverse effects on the foraging efficiency of little penguins continued several days after the storm ceased; even though the water column stratification had returned as before the storm, suggesting a prolonged effect of the storm event on the prey availability. Thus, short-term stochastic events can have an extended impact on the foraging efficiency of penguins. When occurring at a crucial stage of breeding, this may affect breeding success.
Exploring willingness to participate in future Human Infection Studies in Lusaka, Zambia: A nested qualitative exploratory study
Authors: Kunda-Ngándu Evelyn Muleba , Chirwa-Chobe Masuzyo , Mwamba Chanda , Chipungu Jenala , Ng’andu Esnart , Mwanyungwi Chinganya Hope , Simuyandi Michelo , Chilengi Roma , Sharma Anjali
Published: July 2021

Human Infection Studies (HIC) involve intentional infection of volunteers with a challenge agent or pathogen with the aim of understanding and developing vaccines as well as understanding the disease pathophysiology in a well-controlled environment. Though Africa carries the highest burden of vaccine-preventable diseases, the region is only now being primed to conduct HIC relevant to its population. Given the imminent introduction of HIC in Zambia, we sought to understand potential participants’ willingness to volunteer for such studies. We used a qualitative exploratory approach to understand the potential participants’ perceptions on willingness to participate in HIC using the example of typhoid. Healthy adults, recruited using random selection and purposive sampling from higher learning institutions in Lusaka, participated in 15 in-depth interviews (IDIs) and 5 Focus Group Discussions (FGDs) respectively. Participants considered typhoid a serious disease with potential for life-long consequences and death. After sharing audio-visual materials introducing the concepts of HIC, some participants expressed open willingness to participate or alternatively the need to consult parents and professors, and expressed fear of death and illness. Though willing to be quarantined for up to six months, participants expressed concerns regarding separation from family and duties, having insufficient information to decide, inadequate access to care, severe disease, life-long injury or side-effects, death, and vaccine failure. These concerns along with possibility of underlying conditions that compromise individual immunity, competing priorities, parental refusal, and distrust of study or vaccine efficacy could lead to refusal to participate. Reasons for willingness to participate included monetary compensation, altruism and being part of a team that comes up with a vaccine. Though afraid of deliberate typhoid infection, potential participants are willing to consider participation if given adequate information, time to consult trusted persons, compensation and assurance of adequate care.
Nexus of regional integration, socioeconomic determinants and sustainable development in belt and road initiative countries
Authors: Ullah Atta , Pinglu Chen , Ullah Saif , Hashmi Shujahat Haider
Published: July 2021

This study evaluates the nexus of regional integration, socioeconomic determinants and sustainable development (SD) by investigating the effect of health, humans and age structure on sustainable development, with the regional integration (RI) as the moderating variable. Socioeconomic determinants have an important role in sustainable development, while regional integration has fueled up the development process. The sample is based on 64 Belt and Road (BRI) countries from 2003–2018. Pair-wise correlation results indicate that human development, health expenditure and age structure showed a positive relationship with sustainable development. Two-step System-GMM direct effect outcomes are mixed and reveal that human development, health expenditure per capita, age structure, governance index and population size have a positive impact on sustainable development. On the other hand, e-government, government size, and globalization showed negative effects on SD. Apart from that, the moderating channel of regional integration (RI), interaction term with human development and health expenditure, showed a significant and positive impact on sustainable development. However, age structure interaction with regional integration showed a negative impact on SD. Other socio-economic factors, i.e., governance index and population contribute positively towards SD. It can be concluded that the dynamic nature of sustainable development is positive and the net present value is increasing. Therefore, BRI countries are on the sustainable path from 2003–2018, as suggested by economic and social welfare theory. The integration of BRI can be labeled as an entrance to successful sustainable development. However, weak e-government systems, globalization and government resources need to be utilized amicably in Belt and Road countries. Driscoll-Kraay standard-errors regression confirmed and validated the two-step System-GMM results. The findings of the current research have important policy implications for balanced and sustainable growth.
Translation and validation of caring behaviors inventory among nurses in Iran
Authors: Ghafouri Raziyeh , Nasiri Malihe , Atashzadeh-Shoorideh Foroozan , Tayyar-Iravanlou Faraz , Rahmaty Zahra
Published: July 2021

Background and objectives

Nurses’ caring behaviors, professional activities, and behaviors for the benefit of patients, influence patients’ perception of care and satisfaction with the quality of care provided. Caring behaviors of nurses are contextual and various factors such as patients’ social structure, lifestyle, culture, and interests, as well as their biographical, social, and physiological characteristics, can influence perceptions of caring behaviors of nurses, as caring behaviors are an interactive and mental process between patients and nurses. This study was conducted to provide a transcultural translation and psychometric analysis of Caring Behaviors Inventory (CBI) among nurses in Iran.

Methodology

Transcultural translation of the 16-item CBI was performed. Then, face validity (qualitative), content validity (quantitative and qualitative), and construct validity were examined in a cross-sectional study of 509 patients. A demographic questionnaire and the 16-item CBI were sent to enrolled patients via online questionnaires. The reliability of the instrument was assessed by internal consistency using Cronbach’s alpha. Then, construct validity of the single factor CBI was assessed using Confirmatory Factor Analysis (CFA). Since one factor CBI was not confirmed, construct validity was examined using Exploratory Factor Analysis (EFA). The final number of factors was confirmed using CFA.

Results

The internal consistency of the instrument was good with Cronbach’s alpha 0.89. Based on EFA, the CBI were loaded on two factors, eigenvalues >1, no item was removed. The emergent factors were named "Communicating respectfully" and "Professional knowledge and skill". These two factors explained 50.197% of the total variance. Then, CFA showed an acceptable fit for the two factors CBI.

Conclusion

The results showed that the Persian version of the 16-item CBI had adequate validity and reliability. Accordingly, this instrument can be used to study nurses’ caring behaviors.
Variation of B cell subsets with age in healthy Malawians
Authors: Mandala Wilson L. , Longwe Herbert
Published: July 2021

Although a number of previous studies have shown that different lymphocyte subsets, including B cells, vary with age, how different B cell subsets vary with age in Malawian population has not been shown before. We recruited Malawian participants of different ages and analyzed their venous blood samples for different B cell subsets. We found that both percentage and absolute counts of B cells varied with age peaking in the 7 to 12 months age group. Proportion of naïve B cells was highest in neonates and decreased with age whereas the percentage of memory B cells was lowest in neonates and increased with age. When we zeroed in on the age band within which the proportion of B cells was highest, both classical and activated memory B cells increased with age and the naïve followed the opposite trend. These results provide additional knowledge in our understanding of the dynamics of B cell subsets in individuals of a specific ethnicity as they age.
Public understanding of climate change-related sea-level rise
Authors: Priestley Rebecca K. , Heine Zoë , Milfont Taciano L.
Published: July 2021

Sea-level rise resulting from climate change is impacting coasts around the planet. There is strong scientific consensus about the amount of sea-level rise to 2050 (0.24–0.32 m) and a range of projections to 2100, which vary depending on the approach used and the mitigation measures taken to reduce carbon emissions. Despite this strong scientific consensus regarding the reality of climate change-related sea-level rise, and the associated need to engage publics in adaptation and mitigation efforts, there is a lack of empirical evidence regarding people’s understanding of the issue. Here we investigate public understanding of the amount, rate and causes of sea-level rise. Data from a representative sample of New Zealand adults showed a suprising tendency for the public to overestimate the scientifically plausible amount of sea-level rise by 2100 and to identify melting sea ice as its primary causal mechanism. These findings will be valuable for scientists communicating about sea-level rise, communicators seeking to engage publics on the issue of sea-level rise, and media reporting on sea-level rise.
Maintaining oxygen delivery is crucial to prevent intestinal ischemia in critical ill patients
Authors: Schoettler Jochen J. , Kirschning Thomas , Hagmann Michael , Hahn Bianka , Fairley Anna-Meagan , Centner Franz-Simon , Schneider-Lindner Verena , Herrle Florian , Tzatzarakis Emmanouil , Thiel Manfred , Krebs Joerg
Published: July 2021

Background

Intestinal ischemia is a common complication with obscure pathophysiology in critically ill patients. Since insufficient delivery of oxygen is discussed, we investigated the influence of oxygen delivery, hemoglobin, arterial oxygen saturation, cardiac index and the systemic vascular resistance index on the development of intestinal ischemia. Furthermore, we evaluated the predictive power of elevated lactate levels for the diagnosis of intestinal ischemia.

Methods

In a retrospective case-control study data (mean oxygen delivery, minimum oxygen delivery, systemic vascular resistance index) of critical ill patients from 02/2009–07/2017 were analyzed using a proportional hazard model. General model fit and linearity were tested by likelihood ratio tests. The components of oxygen delivery (hemoglobin, arterial oxygen saturation and cardiac index) were individually tested in models.

Results

59 out of 874 patients developed intestinal ischemia. A mean oxygen delivery less than 250ml/min/m2 (LRT vs. null model: p = 0.018; LRT for non-linearity: p = 0.012) as well as a minimum oxygen delivery less than 400ml/min/m2 (LRT vs null model: p = 0.016; LRT for linearity: p = 0.019) were associated with increased risk of the development of intestinal ischemia. We found no significant influence of hemoglobin, arterial oxygen saturation, cardiac index or systemic vascular resistance index. Receiver operating characteristics analysis for elevated lactate levels, pH, CO2 and central venous saturation was poor with an area under the receiver operating characteristic of 0.5324, 0.52, 0.6017 and 0.6786.

Conclusion

There was a significant correlation for mean and minimum oxygen delivery with the incidence of intestinal ischemia for values below 250ml/min/m2 respectively 400ml/min/m2. Neither hemoglobin, arterial oxygen saturation, cardiac index, systemic vascular resistance index nor elevated lactate levels could be identified as individual risk factors.
Electrophysiological priming effects demonstrate independence and overlap of visual regularity representations in the extrastriate cortex
Authors: Makin Alexis D. J. , Tyson-Carr John , Derpsch Yiovanna , Rampone Giulia , Bertamini Marco
Published: July 2021

An Event Related Potential (ERP) component called the Sustained Posterior Negativity (SPN) is generated by regular visual patterns (e.g. vertical reflectional symmetry, horizontal reflectional symmetry or rotational symmetry). Behavioural studies suggest symmetry becomes increasingly salient when the exemplars update rapidly. In line with this, Experiment 1 (N = 48) found that SPN amplitude increased when three different reflectional symmetry patterns were presented sequentially. We call this effect ‘SPN priming’. We then exploited SPN priming to investigate independence of different symmetry representations. SPN priming did not survive changes in retinal location (Experiment 2, N = 48) or non-orthogonal changes in axis orientation (Experiment 3, N = 48). However, SPN priming transferred between vertical and horizontal axis orientations (Experiment 4, N = 48) and between reflectional and rotational symmetry (Experiment 5, N = 48). SPN priming is interesting in itself, and a useful new method for identifying functional boundaries of the symmetry response. We conclude that visual regularities at different retinal locations are coded independently. However, there is some overlap between different regularities presented at the same retinal location.
Clinical utility of the BioFire FilmArray Blood Culture Identification panel in the adjustment of empiric antimicrobial therapy in the critically ill septic patient
Authors: Rule Roxanne , Paruk Fathima , Becker Piet , Neuhoff Matthew , Chausse Julian , Said Mohamed
Published: July 2021

Sepsis and septic shock are key contributors to mortality in critically ill patients and thus prompt recognition and management thereof is central to achieving improved patient outcomes. Early initiation of appropriate antimicrobial therapy constitutes a crucial component of the management strategy and thus early identification of the causative pathogen is essential in informing antimicrobial therapeutic choices. The BioFire FilmArray blood culture identification (BCID) panel is a US Food and Drug Administration (FDA) approved rapid, multiplex polymerase chain reaction assay for use on positive blood cultures. This study evaluated its clinical utility in the intensive care unit (ICU) setting, in terms of amendment of empiric antimicrobial therapy in critically ill patients with sepsis. The assay proved useful in this setting as final results were made available to clinicians significantly earlier than with conventional culture methods. This, in turn, allowed for modification of empirical antimicrobial therapy to more appropriate agents in 32% of patients. Additionally, the use of the BioFire FilmArray BCID panel permitted the prompt implementation of additional infection prevention and control practices in a sizeable proportion (14%) of patients in the study who were harbouring multidrug resistant pathogens. These findings support the use of the BioFire FilmArray BCID panel as a valuable adjunct to conventional culture methods for the diagnosis and subsequent management of critically ill patients with sepsis.
Research on corn production efficiency and influencing factors of typical farms: Based on data from 12 corn-producing countries from 2012 to 2019
Authors: Wang Jiamei , Hu Xiangdong
Published: July 2021

Globally, corn is characterised by high production and high export concentrations, yet the world is experiencing an unprecedented, huge change in this regard. Ensuring the global supply of corn, and thereby the energy and food security of nations has become particularly important. To understand the importance of corn production as an influencing mechanism of global food supplies, the present study researched the corn production of typical farms in major corn-producing and importing countries around the world. I selected the corn input and output data of 18 typical farms in 12 countries from 2012 to 2019, used the data envelopment analysis (DEA) model to calculate the technical efficiency of corn production, and built a tobit model to explore the impact of farming methods, input elements, supporting services, and other factors on efficiency. The study established that the average comprehensive technical efficiency of corn production on a typical farm was 0.863, and the average loss was 13.7%. In addition, it concluded that intensive tillage and conservation tillage have high technical efficiency. It also demonstrated that the proportion of mechanical labour and technical efficiency is in a ‘U’-shaped relationship, among others.
The nature of ICT in technology convergence: A knowledge-based network analysis
Authors: Jung Sungdo , Kim Keungoui , Lee Changjun
Published: July 2021

This study aims to understand the nature of information and communication technology in technology convergence. We form a knowledge network by applying social network theories to Korean patent data collected from the European Patent Organization. A knowledge network consists of nodes representing technology sectors identified by their International Patent Classification codes and edges that link International Patent Classification codes when they appear concurrently in a patent. We test the proposed hypotheses using four indices (degree centrality, E-I index, entropy index, and clustering coefficient). The results show that information and communication technology is easily attached but tends to converge with similar technology and has the greatest influence on technology convergence over other technologies. This study is expected to help practitioners and policymakers understand the structure and interaction mechanisms of technology from a systematic perspective and improve national-level technology policies.