bluuebunny/crossref_metadata_2025 huggingface dataset:
Encapsulation of Silicon Nano Powders via Electrospinning as Lithium Ion Battery Anode Materials
Authors: Xiong Man , Bie Xuan , Dong Yawei , Wang Ben , Zhang Qunchao , Xie Xuejun , Liu Tong , Huang Ronghua
Published: May 2023

Silicon-containing polyester from tetramethoxysilane, ethylene glycol, and o-Phthalic anhydride were used as encapsulating materials for silicon nano powders (SiNP) via electrospinning, with Polyacrylonitrile (PAN) as spinning additives. In the correct quantities, SiNP could be well encapsulated in nano fibers (200–400 nm) using scanning electron microscopy (SEM). The encapsulating materials were then carbonized to a Si-O-C material at 755 °C (Si@C-SiNF-5 and Si@C-SiNF-10, with different SiNP content). Fiber structure and SiNP crystalline structure were reserved even after high-temperature treatment, as SEM and X-ray diffraction (XRD) verified. When used as lithium ion battery (LIB) anode materials, the cycling stability of SiNPs increased after encapsulation. The capacity of SiNPs decreased to ~10 mAh/g within 30 cycles, while those from Si@C-SiNF-5 and Si@C-SiNF-10 remained over 500 mAh/g at the 30th cycle. We also found that adequate SiNP content is necessary for good encapsulation and better cycling stability. In the anode from Si@C-SiNF-10 in which SiNPs were not well encapsulated, fibers were broken and pulverized as SEM confirmed; thus, its cycling stability is poorer than that from Si@C-SiNF-5.
Effects of Aging and Immersion on the Healing Property of Asphalt–Aggregate Interface and Relationship to the Healing Potential of Asphalt Mixture
Authors: Haimei  , Li Lili , Guo Qinglin , Zhao Tongmao , Zuo Pan , E Fengming
Published: May 2023

The self-healing ability of asphalt–aggregate bonding interfaces can maintain the mechanical properties of asphalt mixtures. However, the interface’s healing ability will also be affected by moisture and aging. In order to clarify the influence of moisture and aging on the healing ability of a bonding interface, the effects of healing period and temperature on the self-healing level of interfacial strength were measured. The healing master curve of the strength was established. Thereafter, the effects of soaking time, salt solution concentration, and thermal aging on the healing degree of interfacial strength were measured. Based on digital image processing technology and the meso-finite element method, the influence of the interface on the healing performance of the mixture was simulated and analyzed, which was then verified by the beam bend healing test. The results show that the healing index of bonding strength increases with the ascent of healing temperature and period. Healing index gradually decreases with the extension of soaking period, and the higher the concentration of salt in the solution, the worse the healing performance of interfacial strength. After asphalt aging, the healing potential of the interface is weakened. There is a good linear relationship between the healing level of an asphalt–aggregate interface and the level of strength and fracture energy of the mixture. However, the actual healing level of an asphalt mixture is obviously lower than that of the interface, due to the addition of mineral filler. This paper provides a method for predicting the recovery performance of asphalt pavement.
Study on Austenite Transformation and Growth Evolution of HSLA Steel
Authors: Wang Lu , Wang Shaoyang
Published: May 2023

HSLA steel is widely used in various applications for its excellent mechanical properties. The evolution of austenite transformation and growth has been systematically studied in HSLA steel Q960 during the heating process. A thermal expansion instrument and optical microscope were adopted to analyze the kinetics of austenite transformation, which is a nonlinear continuous process and was accurately calculated by the lever rule based on the dilatation curve at the holding time within 10 min. The austenite growth behavior at temperatures above Ac3 was explored using TEM and DSC. The main precipitates in austenite were Nb-rich and Ti-rich (Nb, Ti)(C, N), and the particle size increased and amount decreased with the increase in the heating temperature, which resulted in the rapid growth of austenite. With the increase in holding temperature and time, the growth of austenite progressed through three stages, and a heat treatment diagram was established to describe this evolution.
A Review of Oxygen Carrier Materials and Related Thermochemical Redox Processes for Concentrating Solar Thermal Applications
Authors: Abanades Stéphane
Published: May 2023

Redox materials have been investigated for various thermochemical processing applications including solar fuel production (hydrogen, syngas), ammonia synthesis, thermochemical energy storage, and air separation/oxygen pumping, while involving concentrated solar energy as the high-temperature process heat source for solid–gas reactions. Accordingly, these materials can be processed in two-step redox cycles for thermochemical fuel production from H2O and CO2 splitting. In such cycles, the metal oxide is first thermally reduced when heated under concentrated solar energy. Then, the reduced material is re-oxidized with either H2O or CO2 to produce H2 or CO. The mixture forms syngas that can be used for the synthesis of various hydrocarbon fuels. An alternative process involves redox systems of metal oxides/nitrides for ammonia synthesis from N2 and H2O based on chemical looping cycles. A metal nitride reacts with steam to form ammonia and the corresponding metal oxide. The latter is then recycled in a nitridation reaction with N2 and a reducer. In another process, redox systems can be processed in reversible endothermal/exothermal reactions for solar thermochemical energy storage at high temperature. The reduction corresponds to the heat charge while the reverse oxidation with air leads to the heat discharge for supplying process heat to a downstream process. Similar reversible redox reactions can finally be used for oxygen separation from air, which results in separate flows of O2 and N2 that can be both valorized, or thermochemical oxygen pumping to absorb residual oxygen. This review deals with the different redox materials involving stoichiometric or non-stoichiometric materials applied to solar fuel production (H2, syngas, ammonia), thermochemical energy storage, and thermochemical air separation or gas purification. The most relevant chemical looping reactions and the best performing materials acting as the oxygen carriers are identified and described, as well as the chemical reactors suitable for solar energy absorption, conversion, and storage.
Design and Characteristic Analysis of an Axial Flux High-Temperature Superconducting Motor for Aircraft Propulsion
Authors: Lee Jun-Yeop , Nam Gi-Dong , Yu In-Keun , Park Minwon
Published: May 2023

In line with global environmental regulations, the demand for eco-friendly and highly efficient aircraft propulsion systems is increasing. The combination of axial flux motors and superconductors could be a key technology used to address these needs. In this paper, an axial flux high temperature superconducting (HTS) motor for aircraft propulsion was designed and its characteristics were analyzed. A 2G HTS wire with high magnetic flux characteristic was used for the field winding of the 120 kW axial flux HTS motor, and the rotational speed and rated voltage of the motor were 2000 rpm and 220 V, respectively. The axial flux HTS motor implements a revolving armature type for solid cooling of the HTS field coil. The electromagnetic and thermal features of the motor were analyzed and designed utilizing a 3D finite element method program. The HTS coil was maintained at the target temperature by effectively designing the current lead and cooling system to minimize heat loss. These results can be effectively used in the design of propulsion systems for large commercial aircraft in the future as well as for the design of small aircraft with less than 4 seats.
LSTM-Based Condition Monitoring and Fault Prognostics of Rolling Element Bearings Using Raw Vibrational Data
Authors: Afridi Yasir Saleem , Hasan Laiq , Ullah Rehmat , Ahmad Zahoor , Kim Jong-Myon
Published: May 2023

The 4.0 industry revolution and the prevailing technological advancements have made industrial units more intricate. These complex electro-mechanical units now aim to improve efficiency and increase reliability. Downtime of such essential units in the current competitive age is unaffordable. The paradigm of fault diagnostics is being shifted from conventional to proactive predictive approaches. As a result, Condition-based Monitoring and prognostics are now essential components of complex industrial systems. This research is focused on developing a fault prognostic system using Long Short-Term Memory for rolling element bearings because they are a critical component of industrial systems and have one of the highest fault frequencies. Compared to other research, feature engineering is minimized by using raw time series sensor data as an input to the model. Our model achieved the lowest root mean square error and outperformed similar research models where time domain, frequency domain, or time-frequency domain features were used as input to the model. Furthermore, using raw vibration data also enabled better generalization of the model. This has been confirmed by evaluating the performance of the developed model against vibration data generated by distinct sources, including hydro and wind power turbines.
Unusual Compositions of Fe-Nb Alloy Precipitates in Iron-Implanted LiNbO3
Authors: Zinnatullin Almaz L. , Petrov Andrei V. , Yusupov Roman V. , Valeev Valerii F. , Khaibullin Rustam I. , Vagizov Farit G.
Published: May 2023

The results of a study of heavy implantation of a LiNbO3 crystal with iron ions are reported for the first time. The X-cut LiNbO3 substrate was implanted with 40-keV Fe+ ions to the fluence of 1.5·1017 ions/cm2. The sample reveals pronounced ferromagnetic properties at room temperature. However, the ferromagnetic response observed in the iron-implanted LiNbO3 differs from the magnetic behavior of other oxides implanted with iron ions under the same conditions. This difference occurs from the unusual magnetic phase composition of the implanted surface layer of the LiNbO3 in which the iron implant precipitates in the form of the nanoscale alloy of metallic iron with niobium. Based on Mössbauer spectroscopy data, we estimated the Nb content in the ion-synthesized nanosized alloy as ~12 at.%, which is much higher than the solid solubility limit of Nb in bulk Fe.
The Classification of Application Users Supporting and Facilitating Travel Mobility Using Two-Step Cluster Analysis
Authors: Mašek Jaroslav , Štefancová Vladimíra , Mazanec Jaroslav , Juránková Petra
Published: May 2023

There is a significant and supported trend toward the achievement of ensuring continuous door-to-door travel in the pan-European transport network. Many innovative programs are dedicated to this topic through assigned projects. This paper is based on the concrete partial results of the H2020 project Shift2Rail IP4 to support the deployment of mobility as a service (IP4MaaS). Attitudes towards travel for demonstration sites were assessed based on the outputs of a sample of respondents from two countries. Cooperation in working on the IP4MaaS project was also provided by a partner from Slovakia (UNIZA) and the Czech Republic (OLTIS). Mathematical statistical tools were used to evaluate the available data to find a connection with promoting mobility as a service. This paper aims to identify differences in travelers’ needs with a focus on using applications using two-step cluster analysis. The research resulted in the identification of differences in traffic behavior within MaaS activities when comparing different clusters reflecting preferences for using a website or mobile application.
Efficient and Effective Directed Minimum Spanning Tree Queries
Authors: Wang Zhuoran , Ouyang Dian , Wang Yikun , Liang Qi , Huang Zhuo
Published: May 2023

Computing directed Minimum Spanning Tree (DMST) is a fundamental problem in graph theory. It is applied in a wide spectrum of fields from computer network and communication protocol design to revenue maximization in social networks and syntactic parsing in Natural Language Processing. State-of-the-art solutions are online algorithms that compute DMST for a given graph and a root. For multi-query requirements, the online algorithm is inefficient. To overcome the drawbacks, in this paper, we propose an indexed approach that reuses the computation result to facilitate single and batch queries. We store all the potential edges of DMST in a hierarchical tree in O(n) space complexity. Furthermore, we answer the DMST query of any root in O(n) time complexity. Experimental results demonstrate that our approach can achieve a speedup of 2–3 orders of magnitude in query processing compared to the state-of-the-art while consuming O(n) index size.
Stability of Traveling Fronts in a Neural Field Model
Authors: Macaluso Dominick , Guo Yixin
Published: May 2023

We investigate the stability of traveling front solutions in the neural field model. This model has been studied intensively regarding propagating patterns with saturating Heaviside gain for neuron firing activity. Previous work has shown the existence of traveling fronts in the neural field model in a more complex setting, using a nonsaturating piecewise linear gain. We aimed to study the stability of traveling fronts in the neural field model utilizing the Evans function. We attained the Evans function of traveling fronts using an integration of analytical derivations and a computational approach for the neural field model, with previously uninvestigated piecewise linear gain. Using this approach, we are able to identify both stable and unstable traveling fronts in the neural field model.
Correction: Bau, S.; Lei, Y. The Groups of Isometries of Metric Spaces over Vector Groups. Mathematics 2022, 10, 4453
Authors: Bau Sheng , Lei Yiming
Published: May 2023

Change in Affiliation Numbers [...]
Electrolytes Play a Role in Detecting Cisplatin-Induced Kidney Complications and May Even Prevent Them—Retrospective Analysis
Authors: Alrfaei Bahauddeen M. , Almutairi Abdulaziz O. , Aljohani Alaa A. , Alammar Hajar , Asiri Abdulaziz , Bokhari Yahya , Aljaser Feda S. , Abudawood Manal , Halwani Majed
Published: May 2023

Background and Objective: Cisplatin is a chemotherapy drug used to treat several types of malignancies. It is a platinum-based compound that interferes with cell division and DNA replication. Cisplatin has been associated with renal damage. This study evaluates the early detection of nephrotoxicity through routine laboratory tests. Materials and Methods: This is a retrospective chart review based on the Saudi Ministry of National Guard Hospital (MNGHA). We evaluated deferential laboratory tests for cancer patients treated with cisplatin between April 2015 and July 2019. The evaluation included age, sex, WBC, platelets, electrolytes, co-morbidities and interaction with radiology. Results: The review qualified 254 patients for evaluation. Around 29 patients (11.5%) had developed kidney function abnormality. These patients presented with abnormally low magnesium 9 (31%), potassium 6 (20.7%), sodium 19 (65.5%) and calcium 20 (69%). Interestingly, the whole sample size had abnormal electrolytes presenting magnesium 78 (30.8%), potassium 30 (11.9%), sodium 147 (58.1%) and calcium 106 (41.9%). Some pathological features were detected, such as hypomagnesemia, hypocalcemia and hypokalemia. In addition, infections that needed antibiotics were dominant in patients treated with cisplatin alone, representing 50% of this group. Conclusions: We report that an average of 15% of patients with electrolyte abnormalities develop renal toxicity and reduced function. Moreover, electrolytes may serve as an early indicator for renal damage as part of chemotherapy complication. This indication represents 15% of renal toxicity cases. Changes in electrolyte levels have been reported with cisplatin. Specifically, it has been linked to hypomagnesemia, hypocalcemia and hypokalemia. This study will help reduce the risk of dialysis or the need for kidney transplant. It is also important to manage any underlying conditions and control patients’ intake of electrolytes.
The Association between COVID-19 Infection and Kidney Damage in a Regional University Hospital
Authors: Žulpaitė Giedrė , Rimševičius Laurynas , Jančorienė Ligita , Zablockienė Birutė , Miglinas Marius
Published: May 2023

Background and Objectives: Kidneys are one of the main targets for SARS-CoV-2. Early recognition and precautionary management are essential in COVID-19 patients due to the multiple origins of acute kidney injury and the complexity of chronic kidney disease management. The aims of this research were to investigate the association between COVID-19 infection and renal injury in a regional hospital. Materials and Methods: The data of 601 patients from the Vilnius regional university hospital between 1 January 2020 and 31 March 2021 were collected for this cross-sectional study. Demographic data (gender, age), clinical outcomes (discharge, transfer to another hospital, death), length of stay, diagnoses (chronic kidney disease, acute kidney injury), and laboratory test data (creatinine, urea, C-reactive protein, potassium concentrations) were collected and analyzed statistically. Results: Patients discharged from the hospital were younger (63.18 ± 16.02) than those from the emergency room (75.35 ± 12.41, p < 0.001), transferred to another hospital (72.89 ± 12.06, p = 0.002), or who died (70.87 ± 12.83, p < 0.001). Subsequently, patients who died had lower creatinine levels on the first day than those who survived (185.00 vs. 311.17 µmol/L, p < 0.001), and their hospital stay was longer (Spearman’s correlation coefficient = −0.304, p < 0.001). Patients with chronic kidney disease had higher first-day creatinine concentration than patients with acute kidney injury (365.72 ± 311.93 vs. 137.58 ± 93.75, p < 0.001). Patients with acute kidney injury and chronic kidney disease complicated by acute kidney injury died 7.81 and 3.66 times (p < 0.001) more often than patients with chronic kidney disease alone. The mortality rate among patients with acute kidney injury was 7.79 (p < 0.001) times higher than among patients without these diseases. Conclusions: COVID-19 patients who developed acute kidney injury and whose chronic kidney disease was complicated by acute kidney injury had a longer hospital stay and were more likely to die.
Effect of Interlayer Construction on TFC Nanofiltration Membrane Performance: A Review from Materials Perspective
Authors: Liu Mingxiang , Zhang Lei , Geng Nannan
Published: May 2023

Polyamide (PA) thin-film composite (TFC) nanofiltration (NF) membranes, which are extensively utilized in seawater desalination and water purification, are limited by the upper bounds of permeability-selectivity. Recently, constructing an interlayer between the porous substrate and the PA layer has been considered a promising approach, as it may resolve the trade-off between permeability and selectivity, which is ubiquitous in NF membranes. The progress in interlayer technology has enabled the precise control of the interfacial polymerization (IP) process, which regulates the structure and performance of TFC NF membranes, resulting in a thin, dense, and defect-free PA selective layer. This review presents a summary of the latest developments in TFC NF membranes based on various interlayer materials. By drawing from existing literature, the structure and performance of new TFC NF membranes using different interlayer materials, such as organic interlayers (polyphenols, ion polymers, polymer organic acids, and other organic materials) and nanomaterial interlayers (nanoparticles, one-dimensional nanomaterials, and two-dimensional nanomaterials), are systematically reviewed and compared. Additionally, this paper proposes the perspectives of interlayer-based TFC NF membranes and the efforts required in the future. This review provides a comprehensive understanding and valuable guidance for the rational design of advanced NF membranes mediated by interlayers for seawater desalination and water purification.
Preparation of Nitrogen and Phosphorus Doped Porous Carbon from Watermelon Peel as Supercapacitor Electrode Material
Authors: Yang Chi , Li Penghui , Wei Yumeng , Wang Yanting , Jiang Bo , Wu Wenjuan
Published: May 2023

The use of green and sustainable biomass-derived compounds to obtain excellent electrochemical properties is important to address growing environmental and energy issues. In this paper, cheap and abundant watermelon peel was used as a raw material to successfully synthesize nitrogen-phosphorus double-doped bio-based porous carbon by a one-step carbonization method and explore it as a renewable carbon source for low-cost energy storage devices. The supercapacitor electrode exhibited a high specific capacity of 135.2 F/g at a current density of 1 A/g in a three-electrode system. A variety of characterization methods and electrochemical tests indicate that porous carbon prepared by this simple method has great potential as electrode materials for supercapacitors.
Magnetic Bistability for a Wider Bandwidth in Vibro-Impact Triboelectric Energy Harvesters
Authors: Qaseem Qais , Ibrahim Alwathiqbellah
Published: May 2023

Mechanical energy from vibrations is widespread in the ambient environment. It may be harvested efficiently using triboelectric generators. Nevertheless, a harvester’s effectiveness is restricted because of the limited bandwidth. To this end, this paper presents a comprehensive theoretical and experimental investigation of a variable frequency energy harvester, which integrates a vibro-impact triboelectric-based harvester and magnetic nonlinearity to increase the operation bandwidth and improve the efficiency of conventional triboelectric harvesters. A cantilever beam with a tip magnet was aligned with another fixed magnet at the same polarity to induce a nonlinear magnetic repulsive force. A triboelectric harvester was integrated into the system by utilizing the lower surface of the tip magnet to serve as the top electrode of the harvester, while the bottom electrode with an attached polydimethylsiloxane insulator was placed underneath. Numerical simulations were performed to examine the impact of the potential wells formed by the magnets. The structure’s static and dynamic behaviors at varying excitation levels, separation distance, and surface charge density are all discussed. In order to develop a variable frequency system with a wide bandwidth, the system’s natural frequency varies by changing the distance between the two magnets to reduce or magnify the magnetic force to achieve monostable or bistable oscillations. When the system is excited by vibrations, the beams vibrate, which causes an impact between the triboelectric layers. An alternating electrical signal is generated from a periodic contact-separation motion between the harvester’s electrodes. Our theoretical findings were experimentally validated. The findings of this study have the potential to pave the way for the development of an effective energy harvester that is capable of scavenging energy from ambient vibrations across a broad range of excitation frequencies. The frequency bandwidth was found to increase by 120% at threshold distance compared to the conventional energy harvester. Nonlinear impact-driven triboelectric energy harvesters can effectively broaden the operational frequency bandwidth and enhance the harvested energy.
Plasmids Increase the Competitive Ability of Plasmid-Bearing Cells Even When Transconjugants Are Poor Donors, as Shown by Computer Simulations
Authors: Rebelo João S. , Domingues Célia P. F. , Nogueira Teresa , Dionisio Francisco
Published: May 2023

Bacterial cells often suffer a fitness cost after conjugative plasmids’ entry because these cells replicate slower than plasmid-free cells. Compensatory mutations may appear after tens of or a few hundred generations, reducing or eliminating this cost. A previous work based on a mathematical model and computer simulations has shown that plasmid-bearing cells already adapted to the plasmid may gain a fitness advantage when plasmids transfer into neighboring plasmid-free cells because these cells are still unadapted to the plasmid. These slow-growing transconjugants use fewer resources, which can benefit donor cells. However, opportunities for compensatory mutations in transconjugants increase if these cells become numerous (through replication or conjugation). Moreover, transconjugants also gain an advantage when transferring the plasmid, but the original donors may be too distant from conjugation events to gain an advantage. To understand which consequence prevails, we performed further computer simulations allowing versus banning transfer from transconjugants. The advantage to donors is higher if transconjugants do not transfer plasmids, mainly when donors are rare and when the plasmid transfer rate (from donors) is high. These results show that conjugative plasmids are efficient biological weapons even if the transconjugant cells are poor plasmid donors. After some time, conjugative plasmids gain other host-benefit genes, such as virulence and drug-resistance.
Mineral Assemblage of Olivine-Hosted Melt Inclusions in a Mantle Xenolith from the V. Grib Kimberlite Pipe: Direct Evidence for the Presence of an Alkali-Rich Carbonate Melt in the Mantle Beneath the Baltic Super-Craton
Authors: Golovin Alexander V. , Tarasov Alexey A. , Agasheva Elena V.
Published: May 2023

This report deals with the first mineralogical examination of secondary crystallized melt inclusions (CMIs) in healed cracks within olivine in a mantle peridotite xenolith from the V. Grib kimberlite pipe (Arkhangelsk diamondiferous province). In contrast to micro/nano-inclusions in diamonds, the studied CMIs are quite large (up to 50 µm), so that the mineral composition of the CMIs can be determined via conventional analytical approaches, e.g., Raman spectroscopy and scanning electron microscopy. Garnet peridotite is a coarse-grained mantle rock that equilibrates at 3.3 GPa and 750 °C (corresponding to a depth of ~100 km). The CMIs are therefore tiny snapshots of melt that existed in the shallow lithospheric mantle and were entrapped in olivine. In total, nineteen mineral species were identified among the daughter magmatic minerals of the CMIs. Various Na-K-Ca-, Na-Ca-, Na-Mg-, Ca-Mg-, Mg- and Ca-carbonates; Na-Mg-carbonates with the additional anions Cl−, SO42− and PO43−; alkali sulfates; chlorides; phosphates; sulfides; oxides; and silicates were established. Within the mineral assemblage, carbonates were predominant, with their abundance being more than 62 vol.%. The CMIs contained twelve alkali-rich minerals; nine of them were Na-bearing and showed bulk molar (Na + K)/Ca ≥ 1. The CMIs’ parental melt was an alkali-rich carbonate liquid that contained low amounts of SiO2 (≤9.6 wt%) and H2O (≤2.6 wt%). According to our estimates, the time of complete equilibration between olivine within the healed cracks and host olivine in the mantle at the calculated P-T parameters for the studied xenolith should be no more than several years. Based on this geologically short time span, a genetic link between the studied CMIs and the magmatism that formed the V. Grib kimberlite pipe is suggested.
Antioxidant Capacity and NF-kB-Mediated Anti-Inflammatory Activity of Six Red Uruguayan Grape Pomaces
Authors: Fariña Emiliana , Daghero Hellen , Bollati-Fogolín Mariela , Boido Eduardo , Cantero Jorge , Moncada-Basualto Mauricio , Olea-Azar Claudio , Polticelli Fabio , Paulino Margot
Published: May 2023

Grape pomaces have a wide and diverse antioxidant phenolics composition. Six Uruguayan red grape pomaces were evaluated in their phenolics composition, antioxidant capacity, and anti-inflammatory properties. Not only radical scavenging methods as DPPH· and ABTS·+ were employed but also ORAC and FRAP analyses were applied to assess the antioxidant potency of the extracts. The antioxidant reactivity of all extracts against hydroxyl radicals was assessed with ESR. The phenol profile of the most bioactive extract was analyzed by HPLC-MS, and a set of 57 structures were determined. To investigate the potential anti-inflammatory activity of the extracts, Nuclear Factor kappa-B (NF-κB) modulation was evaluated in the human colon cancer reporter cell line (HT-29-NF-κB-hrGFP). Our results suggest that Tannat grapes pomaces have higher phenolic content and antioxidant capacity compared to Cabernet Franc. These extracts inhibited TNF-alpha mediated NF-κB activation and IL-8 production when added to reporter cells. A molecular docking study was carried out to rationalize the experimental results allowing us to propose the proactive interaction between the NF-κB, the grape extracts phenols, and their putative anti-inflammatory bioactivity. The present findings show that red grape pomace constitutes a sustainable source of phenolic compounds, which may be valuable for pharmaceutical, cosmetic, and food industry applications.
Optimization of Extraction and Separation Process of Notoginsenoside Fc from Panax notoginseng Leaves
Authors: Guo Zhenghong , Luo Zhonghua , Wu Shao , Yang Chunhong , Xiao Ting , Zhao Yuqing
Published: May 2023

Response surface methodology (RSM) was used to determine the optimal conditions for ultrasound-assisted extraction (UAE) of Notoginsenoside Fc (Fc) from panax notoginseng leaves. The experiment utilized a Box–Behnken design (BBD) and separation conditions were optimized. The optimum extraction conditions were as follows: extraction time = 1.5 h, ethanol concentration = 86%, liquid-to-solid ratio = 19:1. The experimentally obtained values were in accordance with the values predicted by the RSM model. We determined that the RSM model was able to successfully simulate the optimal extraction of Fc from the leaves. Further, Fc was enriched from Panax notoginseng through nine macroporous resins, and HPD-100 macroporous resins were selected for preliminary enrichment of Fc due to its economic costs and benefits. Subsequently, octadecyl silane (ODS) column chromatography was used to improve the purity of Fc to over 90% after separation by ODS column chromatography. Fc with a purity greater than 95% can be obtained by recrystallization. This is the first study that has focused on the extraction and enrichment of Fc from Panax notoginseng leaves using macroporous resin combined with ODS column chromatography, which provides the possibility for further application of Fc.
NH2-Modified UiO-66: Structural Characteristics and Functional Properties
Authors: Timofeev Konstantin L. , Kulinich Sergei A. , Kharlamova Tamara S.
Published: May 2023

The development of new functional materials based on metal–organic frameworks (MOFs) for adsorption and catalytic applications is one of the promising trends of modern materials science. The Zr-based MOFs, specifically UiO-66, are considered as the supports for metallic catalysts for the 5-hydroxymethylfurfural platform molecule reduction into valuable products. The present work focused on the effect of NH2 modification of UiO-66 on its structure and functional properties. The samples were prepared by a solvothermal method. The structure of the obtained materials was studied by X-ray diffraction, IR spectroscopy, UV–visible spectroscopy, and low-temperature nitrogen adsorption. Basic properties were investigated by HCl and CH3COOH adsorption, and electrokinetic properties were studied by electrophoretic light scattering. UiO-66-NH2 samples with different contents of aminoterephthalate linkers were successfully prepared. A gradual decrease in the specific surface area and the fraction of micropores with a diameter of ~0.9 nm was observed with an increase in the aminoterephthalate content. A proportional increase in the total number of basic sites in UiO-66-NH2 samples was established with an increase in the aminoterephthalate content up to 75%. At the same time, a noticeable decrease in the total number of basic sites and an increase in their strength with higher aminoterephthalate content was observed.
Phytochemical Diversity Comparison in Leaves and Roots of Wild and Micropropagated Latvian Sea Holly (Eryngium maritimum L.)
Authors: Nakurte Ilva , Berga Marta , Mežaka Ieva
Published: May 2023

The goal of the current study was to compare the chemical composition of the roots, shoots, and leaves of wild-growing Eryngium maritimum L., and of in vitro and in field-cultivated plants in Latvia. The essential oil yield obtained by hydrodistillation ranged from 0.14% to 0.54%, while analysis of the chemical composition using GC-MS revealed a total of 44 different volatiles, with differences in the types and amounts of volatiles between the leaves and roots. Using 96-well plate techniques, the concentration of total phenolic compounds, saponins, and sugars in the aqueous ethanolic extracts of E. maritimum were assessed, along with their capacity to scavenge stable DPPH radicals. Extracts from roots had a lower concentration of total phenolic compounds compared to those from the leaves of wild grown and cultivated plants but did not differ from in vitro shoots. Root, leaf, and shoot samples of the same genotype from different growth conditions had approximately the same concentration of total saponins, while total sugar concentrations were higher in the roots. The growth conditions had a significant effect on the concentration of total phenolic compounds and antiradical activity, with differences that were significant observed between plant aboveground and belowground parts. Analysis using UHPLC-ESI-q-TOF-MS revealed 63 compounds, with amino acids and hydroxycinnamic acid derivatives (such as chlorogenic and rosmarinic acid) being the major compound groups that significantly differed between plant growth conditions. We also demonstrated that rapid screening of volatile compounds in in vitro plants using headspace gas chromatography mass spectrometry analyses can predict the formation of marker compounds in the same mericlones grown in field conditions. These findings provide valuable insights into the chemical composition of E. maritimum and its potential for use in various applications.
Use of Euphorbia balsamifera Extract in Precursor Fabrication of Silver Nanoparticles for Efficient Removal of Bromocresol Green and Bromophenol Blue Toxic Dyes
Authors: Aljubiri Salha M. , El-Shwiniy Walaa H. , Younes Ayman A. O. , Alosaimi Eid H. , El-wahaab Badr Abd
Published: May 2023

Silver nanoparticles (Ag-NPs) are attracting great attention for their use in various applications, along with methods for their green and facile production. In this study, we present a new eco-friendly approach based on the use of Euphorbia balsamifera extract (EBE) in the green synthesis of silver nanoparticles (Ag-NPs), which are then applied as a reducing and stabilizing agent for the efficient removal of water-based reactive dyes such as bromocresol green (BCG) and bromophenol blue (BPB). The as-prepared Ag-NPs are quasi-spherical in shape, with an average diameter of 20–34 nm. Diverse characterization methods, including X-ray diffractometry (XRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and Brunauer–Emmett–Teller (BET) analysis, were used to analyze these Ag-NPs. The results reveal that water-soluble biomolecules in the Euphorbia balsamifera extract play an important role in the formation of the Ag-NPs. The removal of toxic dyes was studied under varied operational parameters such as Ag-NP dosage, initial dye concentration, pH, stirring time, and temperature. Under the optimum investigated conditions, nearly 99.12% and 97.25% of the bromocresol green and bromophenol blue dyes, respectively, were removed. Both BCG and BPB adsorption were found to adhere to pseudo-second-order kinetics (r22 = 1 and 0.995) and fit the Langmuir isotherm models well (R12 = 0.998 and 0.994), with maximal monolayer adsorption capacities of 20.40 and 41.03 mg/g, respectively. Their adsorption processes were observed to be intrinsically endothermic. The results confirm the potential of the Euphorbia balsamifera extract as a low-cost, nontoxic, and eco-friendly natural resource for the synthesis of Ag-NPs that may be useful in the remediation of hazardous dye-contaminated water sources.
Synthesis and Antitumor Evaluation of Biotin-SN38-Valproic Acid Conjugates
Authors: Dai Yi , Zhang Yang , Ye Tianxiang , Chen Yue
Published: May 2023

Despite the strong anticancer activity of SN38 (7-ethyl-10-hydroxy-camptothecin), the severe side effects and loss of anticancer activity caused by the lack of selectivity to cancer cells and hydrolysis of ring E prevent its clinical application. To address the issue, herein a multifunctional SN38 derivative (compound 9) containing biotin (tumor-targeting group) and valproic acid (histone deacetylase inhibitor, HDACi) was synthesized via click chemistry and evaluated using MTT assay. The in vitro cytotoxicity study showed that compound 9 exhibited superior cytotoxicity than irinotecan against human cervical cancer HeLa cells, albeit it was inferior to SN38. More significantly, compound 9 significantly reduced toxicity in mouse embryonic fibroblast NIH3T3 cells, indicating that compound 9 had the capacity to enhance tumor targeting due to its cell selectivity. Further studies demonstrated that, compared with irinotecan, compound 9 induced similar apoptosis of cancer cells. Consequently, compound 9 can not only improve its tumor-targeting ability mediated by biotin but also exert potent anticancer activity through the effect of SN38 and valproic acid, indicating that the design concept is an effective strategy for the structural modification of SN38.
Highly Efficient Synthesis of Chlorogenic Acid Oleyl Alcohol Ester under Non-Catalytic and Solvent-Free Conditions
Authors: Sun Cong , Liu Hui , Chen Yanran , Wei Xianzhi , Liang Shaohua
Published: May 2023

As a natural polyphenolic compound, chlorogenic acid (CGA) has attracted increasing attention for its various biological activities, such as antioxidant, liver protection, intestinal barrier protection, and effective treatment of obesity and type II diabetes. However, the poor solubility of CGA in hydrophobic media limits its application in the food, drug and cosmetic industries. In order to obtain new hydrophobic derivatives, a highly efficient synthesis approach of CGA oleyl alcohol ester (CGOA) under non-catalytic and solvent-free conditions was developed in this study. The influences of reaction temperature, reaction time, substrate molar ratio, and stirring rate on the CGA conversion were investigated. The results showed that the optimal conditions were as follows: reaction temperature 200 °C, reaction time 3 h, molar ratio of CGA to oleyl alcohol 1:20, and stirring rate 200 rpm. Under these conditions, the CGA conversion could reach 93.59%. Then, the obtained crude product was purified by solvent extraction and column chromatography, and the purify of CGOA was improved to 98.72%. Finally, the structure of CGOA was identified by FT-IR, HPLC-MS and NMR. This study provides a simple and efficient strategy for the preparation of CGOA with the avoidance of catalysts and solvents.
Thermo-Chemical Modification of Cellulose for the Adsorptive Removal of Titan Yellow from Wastewater
Authors: Rahman Ubaid Ur , Humayun Muhammad , Khan Abbas , Farooq Saima , Sadiq Muhammad , Bououdina Mohamed , Shah Nasrullah
Published: May 2023

This research work focuses on the isolation and thermo-chemical modification of cellulose and its application as an adsorbent for the removal of organic pollutants. The used cellulose was collected from a locally available plant (Olive Europa) commonly called Zaitoon. The stem branches of Zaitoon were collected and then kept in water for 40–45 days at room temperature to extract the cellulose fibers. These cellulose fibers were then kept in the Soxhlet apparatus for washing in n-hexane for 72 h. The purified cellulose was divided into three parts: one part was subjected to thermal activation (TAC), the second was modified chemically (CMC) with Benzyl Chloride, while the last one remained un-functionalized (UFC). All the three forms of cellulose were characterized via FTIR and SEM, then utilized for the removal of Titan Yellow (TY) dye from aqueous media via adsorption process by varying the contact time, temperature, concentration of dye and type, and dose of adsorbent. The adsorption efficiencies of all adsorbents were compared under different experimental variables. Thermally activated cellulose showed the best results for the removal of TY compared with other materials. The calculated removal percentage of TY was found to be 97.69, 94.83, 94.83, and 98% under equilibrium conditions of contact time, temperature, adsorbent dose, and TY concentration. Similarly, the uptake capacities of TAC under optimal experimental conditions were found to be 19.56, 18.96, 18.52, and 18.75 mg/g. Thermodynamic studies of TAC, CMC, and UFC showed that the values of ΔG are negative, while those of ΔH and ΔS are positive in all cases and at all temperatures. This indicates that the TY elimination process is endothermic and spontaneous with an entropy-driven nature. The obtained results indicate that the as-fabricated low-cost biomaterials can effectively remove dyes from wastewater through physicochemical interactions. The removal process was influenced by the nature of the adsorbent and the operating variables.
MSM Supplementation Is Associated with Reduced Inflammation and Improved Innate Immune Response following In Vitro LPS-Stimulation in Humans after a Bout of Downhill Running
Authors: McFarlin Brian K. , Vingren Jakob L. , Hill David W. , Bridgeman Elizabeth A.
Published: May 2023

Exercise-induced muscle injury and the subsequent release of Damage-Associated Molecular Patterns (DAMP) result in soreness and inflammation. Dietary supplements may accelerate the rate of recovery by supporting resolution of inflammation. The purpose of this study was to determine if methylsulfonylmethane (MSM) supplementation (30 d prior to exercise and during recovery) altered mRNA expression in LPS-exposed blood leukocytes after a bout of downhill running. Exercise consisted of 60 min of downhill running (−15% grade). Blood (baseline, pre-exercise, 4, 24, 48, and 72 h post-exercise) was diluted (1:10) and combined with LPS (20 µg/mL) for 24 h. Total RNA was isolated from leukocytes and analyzed for 574 immune-associated mRNA (Nanostring nCounter; ROSALIND.BIO). Data were expressed as log2 fold change from baseline for each condition (MSM and placebo). Compared to placebo, MSM supplementation was associated with an improved inflammation response (15 mRNA) and viral immune response (2 mRNA). The largest number of changes were found at 4 and 24 h post-exercise. The key finding in the present study is that MSM supplementation can improve inflammation management and the innate immune response after exercise.
Facile Fabrication of TiO2 Quantum Dots-Anchored g-C3N4 Nanosheets as 0D/2D Heterojunction Nanocomposite for Accelerating Solar-Driven Photocatalysis
Authors: Lee Jin-Hyoek , Jeong Sang-Yun , Son Young-Don , Lee Sang-Wha
Published: May 2023

TiO₂ semiconductors exhibit a low catalytic activity level under visible light because of their large band gap and fast recombination of electron–hole pairs. This paper reports the simple fabrication of a 0D/2D heterojunction photocatalyst by anchoring TiO₂ quantum dots (QDs) on graphite-like C₃N₄ (g-C₃N₄) nanosheets (NSs); the photocatalyst is denoted as TiO₂ QDs@g-C₃N₄. The nanocomposite was characterized via analytical instruments, such as powder X-ray diffraction, X-ray photoelectron spectroscopy, scanning electron microscopy, transmission electron microscopy, t orange (MO) under solar light were compared. The TiO₂ QDs@g-C₃N₄ photocatalyst exhibited 95.57% MO degradation efficiency and ~3.3-fold and 5.7-fold higher activity level than those of TiO₂ QDs and g-C₃N₄ NSs, respectively. Zero-dimensional/two-dimensional heterojunction formation with a staggered electronic structure leads to the efficient separation of photogenerated charge carriers via a Z-scheme pathway, which significantly accelerates photocatalysis under solar light. This study provides a facile synthetic method for the rational design of 0D/2D heterojunction nanocomposites with enhanced solar-driven catalytic activity.
Synthesis and Sensing Performance of Chitin Fiber/MoS2 Composites
Authors: Zhang Yuzhi , Wu Zhaofeng , Sun Jun , Sun Qihua , Chen Fengjuan , Zhang Min , Duan Haiming
Published: May 2023

In this study, chitin fibers (CFs) were combined with molybdenum sulfide (MoS2) to develop high-performance sensors, and chitin carbon materials were innovatively introduced into the application of gas sensing. MoS2/CFs composites were synthesized via a one-step hydrothermal method. The surface properties of the composites were greatly improved, and the fire resistance effect was remarkable compared with that of the chitin monomer. In the gas-sensitive performance test, the overall performance of the MoS2/CFs composite was more than three times better than that of the MoS2 monomer and showed excellent long-term stability, with less than 10% performance degradation in three months. Extending to the field of strain sensing, MoS2/CFs composites can realize real-time signal conversion in tensile and motion performance tests, which can help inspectors make analytical judgments in response to the analysis results. The extensive application of sensing materials in more fields is expected to be further developed. Based on the recycling of waste chitin textile materials, this paper expands the potential applications of chitin materials in the fields of gas monitoring, biomedicine, behavioral discrimination and intelligent monitoring.
Recent Advances in Nanopore Technology for Copper Detection and Their Potential Applications
Authors: Vaneev Alexander N. , Timoshenko Roman V. , Gorelkin Petr V. , Klyachko Natalia L. , Erofeev Alexander S.
Published: May 2023

Recently, nanopore technology has emerged as a promising technique for the rapid, sensitive, and selective detection of various analytes. In particular, the use of nanopores for the detection of copper ions has attracted considerable attention due to their high sensitivity and selectivity. This review discusses the principles of nanopore technology and its advantages over conventional techniques for copper detection. It covers the different types of nanopores used for copper detection, including biological and synthetic nanopores, and the various mechanisms used to detect copper ions. Furthermore, this review provides an overview of the recent advancements in nanopore technology for copper detection, including the development of new nanopore materials, improvements in signal amplification, and the integration of nanopore technology with other analytical methods for enhanced detection sensitivity and accuracy. Finally, we summarize the extensive applications, current challenges, and future perspectives of using nanopore technology for copper detection, highlighting the need for further research in the field to optimize the performance and applicability of the technique.