bluuebunny/crossref_metadata_2025 huggingface dataset:
A Framework Model for Assessing Sustainability Strategies for Tourism Green Supply Chain Management
Authors: Chu Chih-Peng , Chung Kuo-Cheng
Published: December 2014

Environmental awareness is growing worldwide. Building green supply-chain management has become a major challenge for corporations as they strive to contribute to sustainable societies. Meanwhile, supply chain management has recently become a new research topic in tourism studies. This study proposed integrating the balanced score card (BSC), a widely used strategic tool, with the analytic network process (ANP) model to develop tourism green supply chain management (TGSCM) indicators. The results indicated that current market dynamics and growth potential can be understood through the TGSCM. Selecting key factors using the BSC can help identify the balance point between a company’s revenues and its responsibility for environmental protection, thus enabling a unique tourism operations model by which companies can profit while protecting the environment.
Segregation of a Spontaneous Klrd1 (CD94) Mutation in DBA/2 Mouse Substrains
Authors: Shin Dai-Lun , Pandey Ashutosh K , Ziebarth Jesse Dylan , Mulligan Megan K , Williams Robert W , Geffers Robert , Hatesuer Bastian , Schughart Klaus , Wilk Esther
Published: December 2014

Current model DBA/2J (D2J) mice lack CD94 expression due to a deletion spanning the last coding exon of the Klrd1 gene that occurred in the mid- to late 1980s. In contrast, DBA/2JRj (D2Rj) mice, crosses derived from DBA/2J before 1984, and C57BL/6J (B6) mice lack the deletion and have normal CD94 expression. For example, BXD lines (BXD1–32) generated in the 1970s by crossing B6 and D2J do not segregate for the exonic deletion and have high expression, whereas BXD lines 33 and greater were generated after 1990 are segregating for the deletion and have highly variable Klrd1 expression. We performed quantitative trait locus analysis of Klrd1 expression by using BXD lines with different generation times and found that the expression difference in Klrd1 in the later BXD set is driven by a strong cis-acting expression quantitative trait locus. Although the Klrd1/CD94 locus is essential for mousepox resistance, the genetic variation among D2 substrains and the later set of BXD strains is not associated with susceptibility to the Influenza A virus PR8 strain. Substrains with nearly identical genetic backgrounds that are segregating functional variants such as the Klrd1 deletion are useful genetic tools to investigate biological function.
Antiandrogenic therapy with ciproterone acetate in female patients who suffer from both androgenetic alopecia and acne vulgaris
Authors: Coneac Andrei , Muresan Adriana , Orasan Meda Sandra
Published: December 2014

Background. Androgenetic Alopecia in Women (AGA) occurs due to an underlying susceptibility of hair follicles to androgenic miniaturization, caused by androgens. Clinically, AGA is characterized by progressive hair loss, with a marked hair thinning in the fronto-parietal area so that the scalp can be easily seen. Acne vulgaris is androgen-dependent and often affects the skin that has an increased number of oil glands: face, back and chest. Although the sebaceous glands are present on the scalp too, it is very rare to get acne at this site, as the hair acts as a wig and allows the sebum to drain and does not block the pores. Both AGA and Acne Vulgaris are signs of hyperandrogenism. Cyproterone acetate/ethinyl estradiol (2mg/0.035mg) products are authorized for the treatment of androgenetic symptoms in women, such as acne, seborrhea, mild forms of hirsutism and androgenetic alopecia. Our study had a double purpose: - To evaluate the result of the study regimen Melleva 35 (one pill per day, for 3 consecutive months) in patients with moderate to severe acne, suffering also from Androgenetic Alopecia; - To establish the efficacy of the drug on acne and alopecia improvement, both from the doctor’s and patient’s point of view. Patients and methods. After being informed of the aims and procedures of the study, participants provided a written informed consent. A number of 35 female subjects with moderate to severe acne vulgaris remained in the study. The subjects had also been diagnosed as suffering from AGA, on the basis of clinical criteria, including the pattern of hair loss and trichoscopy assessment. Results. 83% of study subjects reported that their hair did not continue to fall after 3 months of antiandrogen therapy. The females were evaluated using trichoscopy and the doctor noticed hair regrowth in 77% of the cases. Regarding the improvement of acne lesions after the treatment, 40% of study subjects recorded good improvement and 26% recorded excellent results with Melleva 35. The acceptance of the treatment was very high, 86% patients were compliant with the study therapy. The rate of adverse events (5 cases) was within the limits of the treatment tested by the study. Almost a third of the total number of subjects (28.5%) reached a good satisfaction level after the treatment, while 37.1% claimed moderate satisfaction. Conclusion. There was no correlation between the age of the subjects and the treatment for acne therefore our first hypothesis was rejected. As a conclusion, antiandrogenic therapy with Melleva 35, 1 pill per day, for 3 consecutive months, shows good results for patients who suffer from both Androgenetic Alopecia and Acne Vulgaris.
Theses Originality: An Initial Effort to Examine Students’ Final Projects
Authors: Zulfikar Teuku , Elismawati Elismawati , Yuhardi Yuhardi
Published: December 2014

Thesis is a prerequisite for graduation in all academic institutions. Higher Education institutions, such as Imam Bonjol Islamic State Institute requires its students to write a thesis in order to graduate. Students write their theses and they were examined before the board of examiners. However, students found it difficult to write ‘good’ theses that show academic honesty and high level of originality. This is a big issue in our institution, this article, therefore examines factors that reduce originality of students’ theses. Having analysed over 10 theses using content analysis method, the authors found that almost all theses contain issues that reduces the originality of the theses. Students frequently commit structural plagiarism, in which they tend to follow the structure of their colleagues’ theses, and only made minor changes. Other finding showed that in stating their research problem, students make a claim without appropriate justification. Issues of referencing and paraphrasing are two important issues that reduce qualities of students’ theses.
Axiology on the Integration of Knowledge, Islam and Science
Authors: Zein Mas’ud
Published: December 2014

The integration of Islamic and science was done through integration-interconnected, referring to ontological, epistemological dan axiological perspectives. This paper will focus on the integration of Islam and science from axiological perspective.  In the view of axiology, science is seen as neutral and value-free; the value of science is given by its users. This condition motivates Muslim scholars to reintegrate science and religion. The first attempt made is my giving ideas on the Islamization of science. The attempt to Islamize the science in the Islamic world is dilemmatic, whether to wrap western science with the label of Islam or Islamic, or transforming religious norms based the Qur’an and the Hadith to fit empirical data. Both strategies are difficult if the effort is not based on the critic of epistemology.
Optimizing Reduced Graphene Oxide with Metallic Nanoparticles for Increasing the Efficiency of Proton Exchange Membrane Fuel Cells
Authors: Isseroff Rebecca , Chen Arthur , Blackburn Lee , Lish Justin , Han Long Tao , Li Hongfei , Rafailovich Miriam
Published: December 2014

The oxidation of CO to CO2 is necessary in the operation of Proton Exchange Membrane Fuel Cells (PEMFCs) since even a small amount of CO that is formed when the PEMFC is operated under ambient conditions is sufficient to poison the Pt catalyst in the electrodes and degrade the performance. Operation using higher loads of Pt catalysts or increasing the purity of the H2 input gas significantly adds to the cost, adversely impacting the commercial development of PEMFCs. We combined graphene oxide (GO) with metallic salts and partially reduced the mixture with sodium borohydride, yielding a metallized form of partially reduced graphene oxide (prGO) platelets that remained in solution. When these platelets were coated on the Nafion membrane of a PEMFC, a 72% increase in the power output was observed, whereas a 62% increase was observed when the membrane was coated with partially reduced graphene oxide without the metallic salts. Results will be presented for AuGO/prGO, PtGO/prGO, and AuPtGO/prGO combinations.
Enhanced Human Bone Marrow Mesenchymal Stem Cell Chondrogenic Differentiation on Cold Atmospheric Plasma Modified Cartilage Scaffold
Authors: Zhu Wei , Keidar Michael , Zhang Lijie Grace
Published: December 2014

Articular cartilage is prone to degeneration and possesses extremely poor self-healing capacity due to its low cell density and absence of blood vessels. It has extensively reported tissue engineered scaffold can be a promising approach for cartilage repair. However, there still remains an inherent lack of desirable scaffolds that stimulate cartilage regrowth with appropriate functional properties. Therefore, in this study, we develop a biomimetic cartilage substitute comprising of electrospun polycaprolactone (PCL) with cold atmospheric plasma (CAP) modified cell favorable surface and sustained bioactive factor (bovine serum albumin (BSA) or transforming growth factor beta 1 (TGF-β1)) incorporated microspheres inside for improving stem cell chondrogenesis and cartilage regeneration. Scanning electron microscopy (SEM) analysis showed the drug delivery spheres homogeneously distribution in the fibrous scaffold. Furthermore, CAP treatment renders the scaffold’s surface more hydrophilic and results in more specific vitronectin adsorption as illustrated by contact angle and ELISA testing. Our results showed that the CAP treated scaffold can greatly improve growth and chondrogenic differentiation (such as increased glycosaminoglycan (GAG) synthesis) of human bone marrow-derived mesenchymal stem cells (MSCs).
Development of a Novel 3D Bioprinted In Vitro Nano Bone Model for Breast Cancer Bone Metastasis Study
Authors: Holmes Benjamin , Zhu Wei , Zhang Lijie Grace
Published: December 2014

Breast cancer (BrCa) is the second commonest cause of cancer-related deaths in women. The metastatic breast cancer exhibits a high affinity to bone, leading to debilitating skeletal complications associated with significant morbidity and poor prognosis. Traditional in vitro and in vivo BrCa bone metastasis models contain many inherent limitations with regards to controllability, reproducibility, and flexibility of design. Thus, the objective of this research is to use a 3D bioprinting system and nanomaterials to recreate a biomimetic and tunable bone model suitable for the effective simulation and study of metastatic BrCa invading and colonizing a bone environment. For this purpose, we designed and 3D printed a series of scaffolds, comprised of a bone microstructure and nano hydroxyapatites (nHA, inorganic nano components in bone). The size and geometry of the bone microstructure was varied with 250 and 150 µm pores, in repeating square and hexagon patterns, for a total of four different pore geometries. 3D bioprinted scaffolds were subsequently conjugated with nHA, using an acetylation chemical functionalization process and then characterized by scanning electron microscope (SEM). SEM imaging showed that our designed microfeatures were printable with the predesigned resolutions described above. Imaging further confirmed that acetylation effectively attached nHA to the surface of scaffolds and induced a nanoroughness. Metastatic BrCa cell 4 h adhesion and 1, 3 and 5 day proliferation were investigated in the bone model in vitro. The cell adhesion and proliferation results showed that all scaffolds are cytocompatible for BrCa cell growth; in particular the nHA scaffolds with small hexagonal pores had the highest cell density. Given this data, it can be stipulated that our 3D printed nHA scaffolds may make effective biomimetic environments for studying BrCa bone metastasis.
Health Outcomes for HIV-Infected Persons Released From the New York City Jail System With a Transitional Care-Coordination Plan
Authors: Teixeira Paul A. , Jordan Alison O. , Zaller Nicolas , Shah Dipal , Venters Homer
Published: December 2014

Objectives. We sought to assess 6-month outcomes for HIV-infected people released from New York City jails with a transitional care plan.

Methods. Jail detainees in New York City living with HIV who accepted a transitional care plan during incarceration were asked to participate in a multi-site evaluation aimed at improving linkages to community-based care. The evaluation included a 6-month follow-up; HIV surveillance data were used to assess outcomes for those considered lost to follow-up.

Results. Participants (n = 434) completed baseline surveys during incarceration in a jail in New York City. Of those seen at 6 months (n = 243), a greater number were taking antiretroviral medications (92.6% vs 55.6%), had improved antiretroviral therapy adherence (93.2% vs 80.7%), and reported significant reductions in emergency department visits (0.20 vs 0.60 visits), unstable housing (4.15% vs 22.4%), and food insecurity (1.67% vs 20.7%) compared with baseline.

Conclusions. Transitional care coordination services facilitate continuity of care and improved health outcomes for HIV-positive people released from jail.
Non-wood forest products based enterprises’ cooperation and business networking forms in central Serbia
Authors: Nedeljkovic Jelena , Nonic Dragan , Rankovic Nenad , Dragovic Nada
Published: December 2014

Collaboration between enterprises includes all activities, which are
undertaken in order to achieve common goals and interests. Business
networking involves the establishment of various forms of associations and
business communities, with or without the creation of new economic entities.
The aim of the paper was to study the forms of cooperation between non-wood
forest products based small and medium enterprises, as well as to determine
the attitudes of their representatives towards cooperation and business
networking with other enterprises in Central Serbia. Research included 91
non-wood forest product based small and medium enterprises and 19
representatives of leading enterprises, which were selected based on
specifically defined criteria. Both the methods of analysis and synthesis and
comparative and statistical methods were applied in the paper. The results
indicate that almost all analyzed enterprises cooperate with other
enterprises. The most common form of cooperation is present ?during selling?
and ?during purchase?. The majority of leading enterprises? representatives
are members of some of the existing associations of entrepreneurs. Based on
the analysis, it was found that there is a need for development of
cooperation between the analyzed enterprises. In accordance with that,
proposals for the improvement of business networking were given. [Projekat
Ministarstva nauke Republike Srbije, br. 43007: Istrazivanja klimatskih
promena i njihovog uticaja na zivotnu sredinu - pracenje uticaja, adaptacija
i ublazavanje?, podprojekat 43007/16-III: Socio-ekonomski razvoj, ublazavanje
i adaptacija na klimatske promene i br. 37008-TR: Odrzivo gazdovanje ukupnim
potencijalima suma u Republici Srbiji
Mavro Vetranovic and Petrarchism
Authors: Spasic Milivoje
Published: December 2014

Mavro Vetranovic ?s relationship to Petrarchism could be described only as a
partial emulation of the themes, motifs, poetic images and language from
Petrarch?s book of poems Il Canzoniere. Ragusan poet didn?t remain at the
level of imitation or stereotypes. Petrarchan characteristics of his poetry
cannot be linked only to the patterns of love poetry of the time, but became
a sort of spreading of Petrarch?s language and motifs that face secular love
and religious moral values which Christian Renaissance tended to preserve.
Benjamin Franklin incognito among Serbs: New mask of Joakim Vujic
Authors: Vojnovic Zarko
Published: December 2014

Joakim Vujic?s book Istino i verojatno sredstvo obogatiti se i svoju kesu
puniti (Istino i verojatno sredstvo obogatiti se i svoju kesu puniti, Buda,
1829) was so far little noticed in serbian book and literature history. It
was found, however, that it is not his original text, but translation of
famous Bejamin Franklin?s Father Abraham?s Speech (widely known as The Way
to Wealth), which was translated by then in many world languages. Paper also
deals with Franklin?s presence in serbian culture of the 19th century.
Domentian ’s "Peregrinations"
Authors: Jankovic Zivorad
Published: December 2014

The paper discusses an unusual trait in Domentian?s hagiographies of far more
completely and accurately describing events, persons and places located
outside the Serbian lands than in those lands proper. Such an occurrence is
also seen in the depiction of Nemanja?s church-founding work and Sava?s
activities in the country and abroad. The state border simultaneously serves
as the boundary between the author?s two literary approaches.
Umetnost, politika, svakodnevica - tematski okviri prijateljstva Marka Murata i Milana Sevica
Authors: Bozic Sofija
Published: December 2014

nema
Dnevnik pesnika Dusana Kapetanovica iz Prvog svetskog rata
Authors: Peric Djordje
Published: December 2014

nema
Instructions, Independence and Uncertainty: Student Framing in Self-Regulated Project Work
Authors: Eklöf Anders , Nilsson Lars-Erik , Ottosson Torgny
Published: December 2014

This study presents an approach to student interaction in self-regulated project work. By combining frame analysis and socio-cultural risk theory, the authors explore the importance of students' framing activities as a basis for their understanding of tasks. The increase in self-regulated work in Swedish schools can be seen as being in line with developments in Europe towards more individualisation. The authors argue that their data provide examples of how the global discourse imposes itself on local discourses. This mode of work, as it appears in the material presented in this article, exemplifies how complex assessment ideas have penetrated the school context. The authors emphasise the concepts of uncertainty, risk and complexity in analysing the framing process, and claim that the focus on these concepts is essential in analysing self-regulated work, contributing to better understanding of self-regulated learning processes.
Macroeconomic Consequences of Accounting: The Effect of Accounting Conservatism on Macroeconomic Indicators and the Money Supply
Authors: Crawley Michael J.
Published: December 2014

This study investigates the macroeconomic consequences of firm-level accounting conservatism. Consistent with conditional conservatism extending to the aggregate level, I demonstrate that annual estimates of aggregate corporate profits and gross domestic product compiled by the U.S. Bureau of Economic Analysis are more sensitive to negative aggregate news than to positive aggregate news. Next, I estimate the dollar value impact of conservatism on measurements of macroeconomic fundamentals. Finally, I show that incorporating the dollar value impact of conservatism increases the explanatory power of a monetary policy reaction function that describes U.S. Federal Reserve interest rate decision behavior. These results suggest that accounting can impact social welfare by altering the measurement attributes of key macroeconomic indicators and by shaping monetary policy decisions that regulate the money supply.

JEL Classifications: M41; E43; E52.
The Association between Extensions in XBRL Disclosures and Financial Information Environment
Authors: Li Shiyou , Nwaeze Emeka T.
Published: December 2014

This study examines the association between XBRL extensions and financial information environments of firms, where “financial information environment” refers to the degree to which a firm's financial information is reflected in the information held/used by investors. An XBRL extension is a customized definition of a financial concept or reporting situation that is not available in the U.S. GAAP Financial Reporting Taxonomy. In 2009, the U.S. Securities and Exchange Commission (SEC) allowed firms to begin to use extensions to add new concepts in their financial disclosures. Critics express concerns that the reporting discretion permitted under the XBRL mandate will reduce comparability of financial disclosures and complicate financial analysis. Proponents contend that XBRL extensions will provide users with new and relevant information. To evaluate the competing views, we employ several proxies for financial information environment and perform analyses for early and later phases of XBRL adoption. We find that XBRL extensions are negatively (positively) associated with financial information environments of firms at the early (later) phases of XBRL adoption. The results for later periods of XBRL adoption provide support for the SEC's policy that allows registrants to use XBRL extensions to increase users' understanding of the information in financial statements.
Progression of Diabetes Retinal Status Within Community Screening Programs and Potential Implications for Screening Intervals
Authors: Leese Graham P. , Stratton Irene M. , Land Martin , Bachmann Max O. , Jones Colin , Scanlon Peter , Looker Helen C. , Ferguson Brian
Published: December 2014

OBJECTIVE

This study aimed to follow the natural progression of retinal changes in patients with diabetes. Such information should inform decisions with regard to the screening intervals for such patients.

RESEARCH DESIGN AND METHODS

An observational study was undertaken linking the data from seven diabetes retinal screening programs across the U.K. for retinal grading results between 2005 and 2012. Patients with absent or background retinopathy were followed up for progression to the end points referable retinopathy and treatable retinopathy (proliferative retinopathy).

RESULTS

In total, 354,549 patients were observed for up to 4 years during which 16,196 patients progressed to referable retinopathy. Of patients with no retinopathy in either eye for two successive screening episodes at least 12 months apart, the conditions of between 0.3% (95% CI 0.3–0.8%) and 1.3% (1.0–1.6%) of patients progressed to referable retinopathy, and rates of treatable eye disease were <0.3% at 2 years. The corresponding progression rates for patients with bilateral background retinopathy in successive screening episodes were 13–29% and up to 4%, respectively, in the different programs.

CONCLUSIONS

It may be possible to stratify patients for risk, according to baseline retinal criteria, into groups with low and high risk of their conditions progressing to proliferative retinopathy. Screening intervals for such diverse groups of patients could safely be modified according to their risk.
The Nature of Mining-Induced Horizontal Displacement of Surface on the Example of Several Coal Mines
Authors: Tajduś Krzysztof
Published: December 2014

The paper presents the analysis of the phenomenon of horizontal displacement of surface induced by underground mining exploitation. In the initial part, the basic theories describing horizontal displacement are discussed, followed by three illustrative examples of underground exploitation in varied mining conditions. It is argued that center of gravity (COG) method presented in the paper, hypothesis of Awierszyn and model studies carried out in Strata Mechanics Research Institute of the Polish Academy of Sciences indicate the proportionality between vectors of horizontal displacement and the vector of surface slope. The differences practically relate to the value of proportionality coefficient B, whose estimated values in currently realized design projects for mining industry range between 0.23r to 0.42r for deep exploitations, whereas in the present article the values of 0.33r and 0.47r were obtained for two instances of shallow exploitation. Furthermore, observations on changes of horizontal displacement vectors with face advancement indicated the possibility of existence of COG zones above the mined-out field, which proved the conclusions of hitherto carried out research studies (Tajduś 2013).
Investigations on the structural, morphological, optical and electrical properties of undoped and nanosized Zn-doped CdS thin films prepared by a simplified spray technique
Authors: Anbarasi M. , Nagarethinam V. , Balu A.
Published: December 2014

CdS and Zn-doped CdS (CdS:Zn) thin films have been deposited on glass substrates by spray pyrolysis technique using a perfume atomizer. The influence of Zn incorporation on the structural, morphological, optical and electrical properties of the films has been studied. All the films exhibit hexagonal phase with (0 0 2) as preferential orientation. A shift of the (0 0 2) diffraction peak towards higher diffraction angle is observed with increased Zn doping. The optical studies confirmed that the transparency increases as Zn doping level increases and the film coated with 2 at.% Zn doping has the maximum transmittance of about 90 %. The sheet resistance (Rsh) decreases as the Zn-doping level increases and a minimum value of 1.113 × 103 Ω/sq is obtained for the film coated with 8 at.% Zn dopant. The CdS film coated with 8 at.% Zn dopant has the best structural, morphological and electrical properties.
Beyond Borders 2014 – Overview of the Biotechnology Landscape
Authors: Zürcher Jürg
Published: December 2014

The global biotechnology industry rebounded strongly in 2013. Public companies achieved double-digit revenue growth and there was a sharp rise in funds. Product successes have boosted revenues, drawn investors and motivated large companies to invest strongly in R&D. However, much
of the industry's growth was driven by a relatively small group of commercial stage companies, increasing the urgency for the rest of the industry to achieve greater efficiency in their drug development efforts.
Business Angels – A Subspecies of the homo oeconomicus ludens
Authors: Hüsler Laurenz , Platzer Erich M.
Published: December 2014

Business Angels invest in start-up companies in their early stage. This type of investor usually has a good knowledge of the start-up's industry sector, and in addition to the funds he invests, his management experience and his network can be useful for start-ups. Business Angel involvement
has shown to improve the success rate and the profitability of start-ups. The article depicts the relationship between entrepreneurs and Business Angels in four case examples.
Commercializing Academic Research Results and the Role of Spin-off Companies
Authors: Reutimann Herbert
Published: December 2014

The commercialization of academic research results is often difficult and requires a flexible approach that depends on the nature of the project. Most technologies are very early-stage and often not mature enough for industry partners or financial investors. Spin-off companies play
an important role in this process. Through their activities universities make an important contribution to the innovation capacity of industry.
Innovate with the CTI National Thematic Networks
Authors: Fürst Susanne Lauber
Published: December 2014

Winning in the global market place with brilliant innovations is the recipe for success for the Swiss economy. Indeed, Switzerland always stands out in the global rankings when it comes to innovation. Yet there is nothing as dangerous as to rest on one's laurels, and this is particularly
true for R&D-based businesses. For this reason CTI, the Commission for Technology and Innovation, offers Swiss companies quick and effective access to knowledge available at Swiss public research institutions, and to international R&D programs promoting application-oriented research.
Knowledge and technology transfer are promoted – via its KTT support – through National Thematic Networks (NTNs), Innovation Mentors and information platforms. The following article highlights the activities of the National Thematic Networks and invites Swiss companies and research institutes to benefit from the multiple offers and services available.
A Novel Approach to Shear-sensitive Fluids When Research and Industry Get Creative Together
Authors: Heinzelmann Elsbeth
Published: December 2014

ZHAW Wädenswil, a pioneer in single-use technology, and Zurich-based LEVITRONIX, the world leader in bearingless motor technology, are developing a novel centrifugal pump with support from the Commission for Technology and Innovation (CTI). By increasing process efficiency, the
pump sets new standards in biopharmaceutical production.
University Presses in the Twenty-first Century: The Potential Impact of Big Data and Predictive Analytics on Scholarly Book Marketing
Authors: Greco Albert N. , Aiss Chelsea G.
Published: December 2014

The use of ‘big data’ and predictive analytics has transformed a sizeable number of industries, from insurance companies to print and e-book online retailers, and both the mass media and the scholarly literature have covered these developments. Online retailers have used big data systems to capture tremendous amounts of data about consumers and their purchases, which has enabled them to use predictive analytics and collaborative filtering systems to make purchase suggestions to consumers. Unfortunately, many university presses—even the largest presses with substantial endowments—have not been able to capitalize on the formidable marketing assets offered by big data and predictive analytics. In this article, the authors review the published literature and significant data sets, and present suggestions for the Canadian and US university press community to launch a non-profit direct-to-consumer Web site generating continuous-time sales and marketing data.
Thermoluminescent characteristics of nano-structure hydroxyapatite:Dy
Authors: Ziaie F. , Moein N. Farhadi , Shafaei M.
Published: December 2014

The thermoluminescence response of Dysprosium doped hydroxyapatite samples with different mol percentage of 0.5, 1 and 2 were studied and compared with the pure hydroxyapatite. The samples were objected to 60Co gamma rays irradiation with doses of 100 mGy to 10 Gy. The main peak in the sample glow curves were obtained at 310 °C. The sensitivity of the 1 mol% Dy doped hydroxyapatite samples show the highest thermoluminescence response. Fading behavior of the irradiated samples was also studied. The experimental results show that the synthetic Dy-doped hydroxyapatite obtained by the hydrolysis method may be used in gamma radiation dosimetry.
Promising new borehole liquids for ice-core drilling on the East Antarctic high plateau
Authors: Sheldon Simon G. , Popp Trevor J. , Hansen Steffen B. , Steffensen Jørgen P.
Published: December 2014

A drill liquid is essential for the purpose of recovering good-quality scientifically useful ice cores at intermediate to deep depths, i.e. >∼100 m. The pressure produced by the liquid helps to eliminate the detrimental effects of the abrupt release of isostatic pressure in the ice during the drilling process, prevents consequential fractures within the ice core, and is essential to produce an even distribution of hydrostatic pressure to balance the ice isostatic pressure and so minimize borehole deformation. To perform these tasks, while minimizing risks to health and the environment, the liquid needs to exhibit specific physical, chemical and biological characteristics. Here we report on two promising candidate drill liquids, ESTISOL™ 140 and ESTISOL™ 165, for use in the extreme conditions found within the ice sheets of Greenland and Antarctica, where the temperature can range from close to 0°C to below −57°C and pressures can exceed 40 MPa. From both the manufacturer’s data and our laboratory tests and observations we report on the physical, chemical and biological characteristics that both liquids exhibit. We also report on how one of the candidates was field-tested on the Greenland ice sheet and the East Antarctic high plateau.
Technical innovations and optimizations for intermediate ice-core drilling operations
Authors: Triest Jack , Mulvaney Robert , Alemany Olivier
Published: December 2014

The British Antarctic Survey, in collaboration with Laboratoire de Glaciologie et Géophysique de l’Environnement, has in recent years successfully drilled to bedrock on three remote sites around the Antarctic Peninsula. Based on the experience from the multi-season project at Berkner Island (948m depth, 2002–05) we optimized the drill set-up to better suit two subsequent single-season projects at James Ross Island (363m depth, 2008) and Fletcher Promontory (654m depth, 2012). The adaptations, as well as the reasons for them, are discussed in detail and include a drill tent set-up without a trench; drilling without a borehole casing with a relatively low fluid column height; and using a shorter drill. These optimizations were aimed at reducing cargo loads and installation time while maintaining good core quality, productivity and a safe working environment. In addition, we introduce a number of innovations, ranging from a new lightweight cable tensioning device and drill-head design to core storage and protection trays. To minimize the environmental impact, all the drill fluid was successfully recovered at both sites and we describe and evaluate this operation.
Rise-Time of FRET-Acceptor Fluorescence Tracks Protein Folding
Authors: Lindhoud Simon , Westphal Adrie , Van Mierlo Carlo , Visser Antonie , Borst Jan
Published: December 2014

Uniform labeling of proteins with fluorescent donor and acceptor dyes with an equimolar ratio is paramount for accurate determination of Förster resonance energy transfer (FRET) efficiencies. In practice, however, the labeled protein population contains donor-labeled molecules that have no corresponding acceptor. These FRET-inactive donors contaminate the donor fluorescence signal, which leads to underestimation of FRET efficiencies in conventional fluorescence intensity and lifetime-based FRET experiments. Such contamination is avoided if FRET efficiencies are extracted from the rise time of acceptor fluorescence upon donor excitation. The reciprocal value of the rise time of acceptor fluorescence is equal to the decay rate of the FRET-active donor fluorescence. Here, we have determined rise times of sensitized acceptor fluorescence to study the folding of double-labeled apoflavodoxin molecules and show that this approach tracks the characteristics of apoflavodoxinʼs complex folding pathway.
A Novel Three-Dimensional Wound Healing Model
Authors: Chen Zhuo , Yang Jessica , Wu Benjamin , Tawil Bill
Published: December 2014

Wound healing is a well-orchestrated process, with various cells and growth factors coming into the wound bed at a specific time to influence the healing. Understanding the wound healing process is essential to generating wound healing products that help with hard-to-heal acute wounds and chronic wounds. The 2D scratch assay whereby a wound is created by scratching a confluent layer of cells on a 2D substrate is well established and used extensively but it has a major limitation—it lacks the complexity of the 3D wound healing environment. Established 3D wound healing models also have many limitations. In this paper, we present a novel 3D wound healing model that closely mimics the skin wound environment to study the cell migration of fibroblasts and keratinocytes. Three major components that exist in the wound environment are introduced in this new model: collagen, fibrin, and human foreskin fibroblasts. The novel 3D model consists of a defect, representing the actual wound, created by using a biopsy punch in a 3D collagen construct. The defect is then filled with collagen or with various solutions of fibrinogen and thrombin that polymerize into a 3D fibrin clot. Fibroblasts are then added on top of the collagen and their migration into the fibrin—or collagen—filled defect is followed for nine days. Our data clearly shows that fibroblasts migrate on both collagen and fibrin defects, though slightly faster on collagen defects than on fibrin defects. This paper shows the visibility of the model by introducing a defect filled with fibrin in a 3D collagen construct, thus mimicking a wound. Ongoing work examines keratinocyte migration on the defects of a 3D construct, which consists of collagen-containing fibroblasts. The model is also used to determine the effects of various growth factors, delivered in the wound defects, on fibroblasts’ and keratinocytes’ migration into the defects. Thus this novel 3D wound healing model provides a more complex wound healing assay than existing wound models.
Evidence of a Biological Control over Origin, Growth and End of the Calcite Prisms in the Shells of Pinctada margaritifera (Pelecypod, Pterioidea)
Authors: Cuif Jean-Pierre , Burghammer Manfred , Chamard Virginie , Dauphin Yannicke , Godard Pierre , Moullac Gilles , Nehrke Gernot , Perez-Huerta Alberto
Published: December 2014

Consistently classified among the references for calcite simple prisms, the microstructural units that form the outer layer of the Pinctada margaritifera have been investigated through a series of morphological, crystallographical and biochemical characterizations. It is often said that the polygonal transverse shape of the prisms result from the competition for space between adjacent crystals. In contrast to this classical scheme the Pinctada prisms appear to be composed of four successive developmental stages from the concentrically growing disks on the internal side of the periostracum to the morphological, structural and compositional changes in both envelopes and mineral components at the end of the prisms. These latest structural and compositional changes predate nacre deposition, so that the end of prism growth is not caused by occurrence of nacre, but by metabolic changes in the secretory epithelium. This sequence makes obvious the permanent biological control exerted by the outer cell layer of the mantle in both organic envelopes and mineralizing organic phases.
Applications of Solid-Phase Microextraction and Gas Chromatography/Mass Spectrometry (SPME-GC/MS) in the Study of Grape and Wine Volatile Compounds
Authors: Panighel Annarita , Flamini Riccardo
Published: December 2014

Volatile compounds are responsible for the wine “bouquet”, which is perceived by sniffing the headspace of a glass, and of the aroma component (palate-aroma) of the overall flavor, which is perceived on drinking. Grape aroma compounds are transferred to the wine and undergo minimal alteration during fermentation (e.g., monoterpenes and methoxypyrazines); others are precursors of aroma compounds which form in winemaking and during wine aging (e.g., glycosidically-bound volatile compounds and C13-norisoprenoids). Headspace solid phase microextraction (HS-SPME) is a fast and simple technique which was developed for analysis of volatile compounds. This review describes some SPME methods coupled with gas chromatography/mass spectrometry (GC/MS) used to study the grape and wine volatiles.
Lignin Hydrolysis and Phosphorylation Mechanism during Phosphoric Acid–Acetone Pretreatment: A DFT Study
Authors: Qin Wu , Wu Lingnan , Zheng Zongming , Dong Changqing , Yang Yongping
Published: December 2014

The study focused on the structural sensitivity of lignin during the phosphoric acid–acetone pretreatment process and the resulting hydrolysis and phosphorylation reaction mechanisms using density functional theory calculations. The chemical stabilities of the seven most common linkages (β-O-4, β-β, 4-O-5, β-1, 5-5, α-O-4, and β-5) of lignin in H3PO4, CH3COCH3, and H2O solutions were detected, which shows that α-O-4 linkage and β-O-4 linkage tend to break during the phosphoric acid–acetone pretreatment process. Then α-O-4 phosphorylation and β-O-4 phosphorylation follow a two-step reaction mechanism in the acid treatment step, respectively. However, since phosphorylation of α-O-4 is more energetically accessible than phosphorylation of β-O-4 in phosphoric acid, the phosphorylation of α-O-4 could be controllably realized under certain operational conditions, which could tune the electron and hole transfer on the right side of β-O-4 in the H2PO4− functionalized lignin. The results provide a fundamental understanding for process-controlled modification of lignin and the potential novel applications in lignin-based imprinted polymers, sensors, and molecular devices.
Design and Synthesis of Chalcone Derivatives as Inhibitors of the Ferredoxin — Ferredoxin-NADP+ Reductase Interaction of Plasmodium falciparum: Pursuing New Antimalarial Agents
Authors: Suwito Hery , Jumina  , Mustofa  , Pudjiastuti Pratiwi , Fanani Much , Kimata-Ariga Yoko , Katahira Ritsuko , Kawakami Toru , Fujiwara Toshimichi , Hase Toshiharu , Sirat Hasnah , Puspaningsih Ni
Published: December 2014

Some chalcones have been designed and synthesized using Claisen-Schmidt reactions as inhibitors of the ferredoxin and ferredoxin-NADP+ reductase interaction to pursue a new selective antimalaria agent. The synthesized compounds exhibited inhibition interactions between PfFd-PfFNR in the range of 10.94%–50%. The three strongest inhibition activities were shown by (E)-1-(4-aminophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one (50%), (E)-1-(4-aminophenyl)-3-(2,4-dimethoxyphenyl)prop-2-en-1-one (38.16%), and (E)-1-(4-aminophenyl)-3-(2,3-dimethoxyphenyl)prop-2-en-1-one (31.58%). From the docking experiments we established that the amino group of the methoxyamino chlacone derivatives plays an important role in the inhibition activity by electrostatic interaction through salt bridges and that it forms more stable and better affinity complexes with FNR than with Fd.
Dispersive Fourier Transformation for Versatile Microwave Photonics Applications
Authors: Wang Chao
Published: December 2014

Dispersive Fourier transformation (DFT) maps the broadband spectrum of an ultrashort optical pulse into a time stretched waveform with its intensity profile mirroring the spectrum using chromatic dispersion. Owing to its capability of continuous pulse-by-pulse spectroscopic measurement and manipulation, DFT has become an emerging technique for ultrafast signal generation and processing, and high-throughput real-time measurements, where the speed of traditional optical instruments falls short. In this paper, the principle and implementation methods of DFT are first introduced and the recent development in employing DFT technique for widespread microwave photonics applications are presented, with emphasis on real-time spectroscopy, microwave arbitrary waveform generation, and microwave spectrum sensing. Finally, possible future research directions for DFT-based microwave photonics techniques are discussed as well.
Impact of probiotic Lactobacillus plantarum TENSIA in different dairy products on anthropometric and blood biochemical indices of healthy adults
Authors: Hütt P. , Songisepp E. , Rätsep M. , Mahlapuu R. , Kilk K. , Mikelsaar M.
Published: December 2014

The blood pressure-lowering effect of dairy products holds the potential to decrease the risk of cardiovascular disease (CVD). An open question is if the successful expression of functional properties of the probiotic strain depends on host biomarkers and/or food matrix properties. The probiotic Lactobacillus plantarum strain TENSIA® (DSM 21380) is a novel microorganism with antimicrobial and antihypertensive functional properties. The aim of this study was to characterise the functional properties of the probiotic L. plantarum TENSIA and compare its effects on host anthropometric, clinical, and blood biomarkers when consumed with cheese or yoghurt. This study involved two double-blinded randomised placebo-controlled exploratory trials (ISRCTN15061552 and ISRCTN79645828) of healthy adults over a three-week period. The three-week consumption of probiotic L. plantarum TENSIA in a daily dose of 1×1010 cfu in probiotic cheese or a daily dose of 6×109 cfu in yoghurt with different content of carbohydrates, proteins, and lipids did not significantly change the body mass index (BMI), plasma glucose and lipid levels, or inflammatory markers in the blood. Reduced lowered systolic and diastolic blood pressure values were detected, regardless of food matrix or baseline values for blood pressure and BMI. In conclusion, our study showed that three-week consumption of the probiotic L. plantarum TENSIA either in cheese or yoghurt lowered diastolic and systolic blood pressure regardless of food matrix and baseline values of blood pressure and BMI, confirming the impact of the functional properties of the probiotic strain in decreasing CVD risk.
Risk Factor Outcome Comparison Between Exercise-Based Cardiac Rehabilitation, Traditional Care, and an Educational Workshop
Authors: Adams Jenny L. , Nuss Terri , Banks Carolyn , Hartman Julie , Segrest Wendy , Spears Joanne , Yount Phyllis , Bryant Lona
Published: December 2014

Background:

This study examined risk factor outcomes among patients who attended cardiac rehabilitation sessions, those who received traditional care, and those who attended Leap for Life® workshops.

Methods:

A non-equivalent, three-group design was used in this observational study. Baseline and 12-month measurements were collected for 217 participants. Analysis of covariance was performed to determine differences between groups on outcome variables.

Results:

The only significant finding was in participants with an initial high-density lipoprotein value of less than 40. High-density lipoprotein levels increased more in the cardiac rehabilitation group than in the traditional care group (30.54 to 37.48 versus 30.17 to 33.67 [
F
= 4.577,
p
= .035]).

Conclusions:

Based on these findings, a strong case can be made for the transition to more individually intense and focused risk factor modification strategies for patients in cardiac rehabilitation programs.
Planning and Implementing an Interdisciplinary Diabetes Workshop for Healthcare Professionals
Authors: Valdez Gloria M. , Dadich Karen A. , Boswell Carol , Cannon Sharon , Irons Brian K. , Vickers Patricia , Esperat Christina
Published: December 2014

A diabetes education program for healthcare professionals evolved out of a series of discussions among healthcare providers. This group realized the importance and the necessity of developing a current knowledge base for themselves, their clients, and their clients’ families. The target audiences for this program were physicians, nurses, pharmacists, and dietitians who could be eligible to work toward becoming a certified diabetes educator. This article discusses the process used to develop and conduct these workshops. The lessons learned during this project are provided for consideration by others seeking to address common concerns and challenges in other areas of clinical practice.
The Need for a Community Diabetes Education Curriculum for Healthcare Professionals
Authors: Irons Brian K. , Vickers Patricia , Esperat Christina , Valdez Gloria M. , Dadich Karen A. , Boswell Carol , Cannon Sharon
Published: December 2014

Healthcare professionals need valuable up-to-date information on diabetes management and skills to treat and educate patients with diabetes mellitus. The Diabetes Education for Healthcare Professionals program was developed to provide healthcare professionals with current diabetes management skills. It was also designed to increase the number of certified diabetes educators in the area in which it was delivered. The program enrolled 147 participants and was delivered on four different occasions. Fifty-five of those participants stated a strong interest in pursuing certified diabetes educator certification, which may significantly increase the number of certified diabetes educators in both rural and urban areas of West Texas.