bluuebunny/crossref_metadata_2025 huggingface dataset:
Resistance To Antiretroviral Therapy In People With HIV
Authors: Asryadin Asryadin , Yuniati Nilasari Indah , Panjenengan Lalu Addien Faqih , Satriana Baiq Trisna
Published: October 2023

Human Immunodeficiency Virus (HIV) is a virus that damages the immune system, and has RNA genetic material which is converted by the reverse transcriptase enzyme into DNA. This research aims to determine the existence of resistance by identifying mutations related to drug resistance in HIV-1, especially in the genes encoding the PR and RT enzymes which are the targets of ARVs. This research uses the observational method. Research data analysis was carried out in the form of descriptive data analysis of the output of each formula based on the results of HIV measurements. This study contains a series of reviews that focus on the topic and incidence and possibility of HIV drug resistance (ART) in PLHIV/PLWHA. The main and important thing in detecting the possibility of resistance to ARV therapy is by examining the genotype and phenotype. Standardization between laboratories for drug resistance studies through the use of various methods, especially to identify mixed bases that cause estimated resistance mutations. Additionally, sequencing of protease, RT, and/or integrase is used to identify the clinical significance of DRM. There are two genetic mechanisms of NRTI resistance, namely: (1) discriminative mutations that activate RT to differentiate between the dideoxy-NRTI chain terminator and the cell's own dNTP; and (2) unblocking mutations that facilitate phosphorylytic excision of NRTI-triphosphate from viral DNA. Blocking mutations are also referred to as thymidine analogue mutations (TAMs).   ARV resistance can be detected by examining the virus genotype which aims to determine the occurrence of mutations in one of the virus codons compared to ARV-sensitive wild type HIV-1 and by in vitro phenotyping, where this method takes quite a long time and is usually focused on finding a regimen new drug
(NO)TEMATIZACIÓN E IDEOLOGÍAS LINGÜÍSTICAS EN LOS PROGRAMAS DE LOS MIEMBROS DE LA CONVENCIÓN CONSTITUCIONAL CHILENA
Authors: ESPINOZA MARCO , REYES ANTONIA , GÁEZ DIEGO , ORTIZ JOSÉ
Published: October 2023

Desde una perspectiva sociolingüística crítica, en el presente trabajo cualitativo y exploratorio, identificamos, analizamos y discutimos la (no)tematización de las diferentes lenguas del territorio chileno y las ideologías lingüísticas en los programas de los candidatos que resultaron electos para conformar la Convención Constitucional chilena. El análisis de contenido de estos programas, entendidos como discursos y prácticas comunicativas situadas, reveló que las lenguas no constituían un tema para la gran mayoría de los candidatos no-pueblos originarios. Las lenguas indígenas son tematizadas con mayor frecuencia que la lengua de señas, mientras que las lenguas de grupos migrantes no son mencionadas. El castellano solo se menciona una vez. Los candidatos de pueblos originarios tematizaban de manera mayoritaria (y solamente) las lenguas indígenas. Las ideologías predominantes en el caso de las lenguas indígenas son una nación una lengua y la ideología monoglósica. Para el caso de la lengua de señas chilena, predomina la idea de la discapacidad. En tanto prácticas comunicativas, estos programas se constituyen en una política lingüística en la práctica que refuerza un monolingüismo hegemónico en castellano en la esfera discursiva pública. Discutimos las implicancias de estos hallazgos para las luchas políticas de los grupos lingüísticos minorizados, para el actual momento constituyente y para la sociolingüística crítica.
Identidad visual con iconografía ancestral en la industria de la moda
Authors: Ruiz Ruiz Ingrid Ninoshka , Andrade Vargas Jorge Fernando
Published: October 2023

La proyección de imagen empresarial se destaca como un activo fundamental en la estrategia de comunicación. La identidad visual y la incorporación de iconografía ancestral emergen como recursos poderosos para transmitir la historia, tradición y el orgullo de un país. Esta combinación puede convertir a las marcas en íconos competitivos en el mercado internacional. Este artículo explora la relación entre la identidad visual y la iconografía ancestral en las marcas de moda ecuatoriana, analizando cómo fortalecen la identidad cultural y la competitividad global. Realizamos una exhaustiva revisión bibliográfica centrada en la identidad visual, el branding cultural y sus influencias. Además, analizamos casos de marcas de moda ecuatoriana que destacan por promover la identidad cultural a través de iconografía ancestral. La identidad visual es un activo estratégico para las empresas. La forma en que una marca se presenta visualmente impacta en la percepción de los consumidores y su éxito en el mercado. Las marcas que incorporan iconografía ancestral conectan con la historia y cultura de su país, fortaleciendo su identidad y generando orgullo tanto local como internacional. Los casos estudiados revelan marcas de moda ecuatoriana que triunfan en el mercado global gracias a la iconografía ancestral. Estas marcas demuestran que la conexión con la cultura es clave para el éxito internacional. En resumen, este análisis destaca la importancia de la identidad visual y la iconografía ancestral en las marcas de moda ecuatoriana. Las marcas que abrazan su herencia cultural no solo se diferencian en un mercado competitivo, sino que también transmiten respeto y aprecio por sus raíces y la historia de Ecuador. Estos resultados respaldan la idea de que la identidad visual y elementos culturales son herramientas poderosas para competir en el mercado internacional y conectar emocionalmente con los consumidores.
Kinematic and optimal design of a three-wheeled holonomic omnidirectional robot platform for mobile manipulation tasks
Authors: Rutvik Mehenge  , Niket Satoskar  , Anukool Shidhore  , N. Mohamed Arshath
Published: October 2023

Mobile manipulator robots are increasingly vital in industrial and service sectors, serving roles in assembly, inspection, and hazardous environments. The integration of a manipulator with a mobile robot base imposes unique demands on the vehicle's drive system. This paper introduces a three-wheel holonomic omnidirectional robot designed for mobile applications. It explores kinematic equations, electronic integration, and mechanical design for holonomic motion. This platform excels in mobility, capable of simultaneous translation and rotation, facilitating precise multidirectional motion. Its equilateral truncated triangular structure ensures stability, supporting up to 4 kg. With three omnidirectional wheels and DC motors, controlled by EMS 30A H-Bridge and Arduino Mega 2560, it offers an open platform for research and development. This robust platform aligns kinematic calculations with mathematical models, promising efficiency for diverse mobile manipulation robot applications.
Relationship between serum ferritin level and outcome of septic shock in children
Authors: Dewa Ayu Angga Rainingsih  , I Made Gede Dwi Lingga Utama  , Ida Bagus Gede Suparyatha  , Ida Bagus Subanada  , I Gusti Ngurah Made Suwarba  , Dyah Kanya Wati
Published: October 2023

Background Sepsis is a life-threatening organ dysfunction caused by dysregulation of the immune system against infection. Sepsis that leads to septic shock is one of the causes of morbidity and mortality in children who are treated in intensive care and inpatient rooms. Ferritin is a protein whose synthesis is increased in inflammatory and infectious conditions and can be a marker of active infection. The cut off ferritin in septic shock was not established and not absolutely clear in our patients. Objective To determine the cut-off value of ferritin levels in patient with septic shock and the relationship between high serum ferritin levels with poor outcome (mortality) in pediatric patients with septic shock. Methods This study used an observational-analytic design with prospective cohort study design. The research was conducted in pediatric ward, Prof. Dr. I.G.N.G. Ngoerah hospital from October 2021 to August 2022. Data analysis was done in 2 steps, first by using receiver operator characteristic curves to find the optimal cut-off point value and the second step was bivariate and multivariate analysis to determine the relationship between ferritin levels and the outcome of septic shock in children. The significance level (α) of this study was set with probability value less than 0.05. Results This study involved 76 subjects, 49 subjects died and 27 subjects survive. The Area Under Curve of ferritin levels from ROC curve obtained was ​​83.7% (p=0.001, 95% CI 74.2%-93.1%). The cut off for ferritin level 660.78 ng/ml gave sensitivity 85.7% and specificity 77.8% for mortality in patients with septic shock. The value of ferritin levels ³ 660.78 generate mortality risk 39.50 times (95% CI 8.057 – 183.422) in pediatric patients with septic shock. Conclusion Higher ferritin levels can increase the risk of mortality in pediatric septic shock patients.
The biomedical importance of zinc and its use in treating COVID-19: An overview
Authors: Chaithra G  , Praveen Kumar Gupta
Published: October 2023

Zinc deficiency makes us to realize the importance of zinc to human health becomes obvious. Even a mild zinc deficiency can impair hematopoietic and immune functions, leading to the destruction of pro-inflammatory phenotypes and redox metabolism. Although dysfunction of the immune system is the most obvious effect, zinc deficiency can destroy the function of many types of tissue cells. Decreased adhesion molecules and tight junction proteins and increased cell death lead to barrier dysfunction and possible organ failure. Zn deficiency, when combined, weakens the human body's resistance to pathogens while also increasing the risk of an overactive immune response that can cause tissue damage. The coronavirus disease (COVID-19) pandemic is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This has prompted scientists all over the world to work on finding new treatments for COVID-19. Aside from a weakened immune system, zinc deficiency causes several metabolic changes. The role of zinc in inhibiting covid-19, as well as the negative effects of zinc deficiency, are discussed in this review.
Antibacterial cationic polymers: A novel approach for combating bacterial infections
Authors: Ranjeeta Bansala  , Swagata Chatterjee
Published: October 2023

Bacterial resistance is a growing global health problem that is impeding effective disease treatment. The emergence of multidrug-resistant bacteria threatens the viability of conventional antibiotics. Bacterial adhesion and biofilm formation are critical parameters for establishment of infection in the host. Antimicrobial cationic polymers have emerged as a promising tool for combatting bacterial infections due to their potential to inhibit bacterial adhesion, biofilm formation and growth. Cationic polymers have broad-spectrum antibacterial activity against a variety of bacteria, including strains that are resistant to antibiotics. Optimizing polymer efficacy, reducing potential toxicity, and improving stability remain important research areas. Several nanopolymers (nanoparticle conjugated polymers) naturally have antibacterial properties. They can be utilized by health care institutions to make antimicrobial coatings for surfaces or medical devices, thus lowering the risk of healthcare-associated infections. This review highlights an update on recent advances in the synthesis of cationic polymers and their formulations with minimal host side effects and maximum antibacterial efficacy.
Risk factors associated with hypercoagulability in Covid-19 patients at Ndola Teaching Hospital and Levy Mwanawasa University Teaching Hospital, Zambia
Authors: Alick Mwambungu  , Lydia Korolova  , Bornwell Sikateyo
Published: October 2023

Individuals with coronavirus disease 2019 (COVID-19) may have coagulation abnormalities that create a hypercoagulable state, raising questions about appropriate evaluations and interventions to prevent or treat thrombosis. Since some COVID-19 patients appear to be at higher risk of thrombosis and increased mortality than others, such patients need to be given special protection against SARS-COV-2 infection. To identify these vulnerable groups, the risk factors for hypercoagulability must be found. Additionally, the identification of risk factors can contribute to research into the pathophysiological processes of COVID-19 from which possible treatment strategies can be developed. The aim of this study was to determine risk factors associated with hypercoagulability in COVID-19 patients at Ndola Teaching Hospital (NTH) and Levy Mwanawasa University Teaching Hospital (LMUTH). This was a Hospital based research and utilised cross sectional study design. The study reported statistically significant increased proportion of hypercoagulability in unvaccinated, obese, hypertensive, Cardiovascular Disease and diabetic Covid-19 patients aged above 65 years. It was further revealed that male COVID-19 patients, Chronic Obstructive Pulmonary Disease (COPD), and Asthmatic COVID-19 patients had increased proportion of patients in hypercoagulable state but the differences were not significant.. Further our study reported reduced proportion of hypercoagulability in Blood Group O COVID-19 patients than those with A, B and AB blood Group though these differences were not statistically significant. Univariate and multivariate analysis revealed that age, obesity, hypertension, Diabetes mellitus, CKD, and CVD were independent risk factors for hypercoagulability in COVID-19 patients while gender, Asthma and COPD were not independent risk factors for hypercoagulability in COVID-19 Patients.. Additionally, the study noted that unvaccinated Covid-19 patients were at an increased risk of hypercoagulability compared to vaccinated patients. The study concluded that that age, obesity, hypertension, Diabetes mellitus, Chronic Kidney Disease (CKD), and Cardiovascular disease (CVD) are risk factors for hypercoagulability in COVID-19 patients and unvaccinated COVID-19 patients were at risk of hypercoagulability than the vaccinated patients. To mitigate the risk of hypercoagulable states, it is recommended to closely monitor COVID-19 patients with the above conditions by implementing preventative measures to help reduce the incidence of hypercoagulability in these patients and to intensify COVID-19 vaccination programmes.
Sexual dimorphism, length-weight relationship, and condition factor of Hampala ampalong (Bleeker, 1852) from Kalong Floodplain, Ogan Komering Ilir Regency
Authors: Azmi Afriansyah  , Muslim Muslim  , Reno Irawan
Published: October 2023

Sumatra hampala or kebarau fish, Hampala ampalong (Bleeker, 1852) is one of the fish species found in Kalong Floodplain in the Ogan Komering Ilir Regency, South Sumatra, Indonesia. This study aimed to determine sexual dimorphism, length-weight relationship and condition factor of H. ampalong. The study method used was direct observation with purposive sampling technique. The total fish obtained consisted of 12 male and 12 female. The results showed that almost all morphometric characters of female were longer than male except for head length which determined that male longer than female. The head length of male was 2.28 ± 1.04 while the head length of female was 2.27 ± 0.85 it could be assumed that the sexual dimorphism seen from the difference in head length. While the meristic characteristics there was no difference between male and female; dorsal fin spine and rays (I. 7-8), ventral fin rays (6-8), pectoral fin rays (13), anal fin rays (6-9) and caudal fin rays (18). The length-weight relationship of male obtained a linear regression equation y = 0.0092x3.0418 with R2 = 89.45%, the value of b obtained was 3.0418 which means that the growth pattern of male was isometric (b=3), while the linear model regression equation of female fish y = 0.0238x2.6975 with R2 = 76.74%, the value of b obtained was 2.6975 which indicates that the growth pattern of female includes negative allometric (b<3). The value of the relative condition factor of male and female were K>1 which means the value of fish condition were in good.
Characterization, profiling, and molecular docking analysis of phytochemicals derived from Daucus carota for evaluating their potential role in cardiovascular disease (CVD) assessment
Authors: Lalit Mohan Trivedi  , Sunanda Saxena  , Shweta Sharma  , Ritika  , Meenu Beniwal  , Sudhanshu Kumar Jha  , Avinash Kumar Rao  , Mohd Ruman Khan
Published: October 2023

Cardiovascular disease (CVD) remains a significant global health challenge, prompting this research manuscript's investigation into the potential contributions of phytochemicals extracted from Daucus carota, commonly known as carrots, in assessing CVD. The study employed a comprehensive approach, including spectral characterization through 1H and 13C NMR, and quantitative profiling using HPTLC, to identify and quantify phytochemical markers, namely, p-hydroxybenzoic acid, caffeic acid, and chlorogenic acid. Spectral characterization using NMR confirmed the presence of saturated and unsaturated moieties within these markers. Subsequently, these phytoconstituents, three in number found in carrot roots, underwent In-silico screening using the protein structure (PDB ID: 5JAD). The results of the molecular docking simulations revealed that these phytoconstituents exhibited higher docking scores and lower glide energies compared to standard drugs like Felodipine. The methodology and key research sections encompassed the collection, identification, and preparation of carrot samples, as and-performance thin-layer chromatographic TLC and (HPTLC) profiling, NMR spectroscopy, and molecular docking studies. The result findings offer valuable insights into the potential health benefits of carrot phytochemicals, encourage further exploration of varietal differences, suggest optimization of extraction techniques, and advocate for the assessment of synergistic effects. Importantly, the promising cardioprotective properties of these phytochemicals highlight their role in preventing and managing cardiovascular disease (CVD). The phytoconstituents derived from Daucus carota, as evidenced by HPTLC and In-silico studies, demonstrate substantial anti-cardiac potential. This positions them as valuable phytochemicals for the development of innovative anti-CVD/anti-CHF medications, offering promising avenues for the treatment of diverse cardiac diseases and disorders in the future.
Design, fabrication and performance evaluation of a solar powered cassava grater
Authors: Chima Kalu Ndukwe  , Musbau Olajide Oluwe
Published: October 2023

This study evaluated some performance indicators of a solar powered cassava grating machine. The designing and fabrication of a prototype solar cassava grating machine was carried out using components that included food grade metal sheet metal bar, wooden roller/ grater encasing, pulley, belt, bolts, nuts. The fabricated grater was then connected via a pulley, roller, belt connection to a 1 horsepower rated Ac motor connected to a solar powering system. The solar powering system comprised of components such as 4units of solar panels (235wats), 1unit of charge controller (50 amp), 1unit of inverter (3.5Kva), and 2units of 200Amh rated batteries in series connection. Also, a mass of cassava weighing 100kg was grated in batches using the solar powered cassava grater and the grating time was determined to be 14.90mins (0.25hr). The value was significantly lower than that obtained from grating the same quantity of cassava roots on the combustion engine powered cassava grater (conventional grater) of similar specification which recorded a grating time of 17.60mins. (0.27hr). Values, obtained for some performance indicators, showed a grating efficiency and rate of 96.16% and 0.0025hr/kg respectively. Also, the throughput capacity was determined to be 400.00kg/hr. while power consideration yielded 0.0019kwh/kg for each kg of cassava roots grated. The result showed an overall improvement in all performance indices evaluated which is indicative of improvement in the efficiency.
Analisa Kelayakan Dasar Unit Pengolahan Ikan Kayu (Keumamah) Di Banda Aceh
Authors: Rahmadani Rahmadani , Apriliani Dwi , Hayuningtyas Afwa
Published: October 2023

Pengolahan ikan kayu (keumamah) merupakan proses pengolahan ikan yang sudah dilakukan sejak lama, proses pengolahan ikan yang berbasis pengolahan makanan khas tradisional menjadi penting untuk melestarikan cagar budaya dalam pengolahan ikan. Masalah keamanan pangan yang membuat konsumen semakin selektif dalam memilih produk dan upaya menjaga kepercayaan konsumen pada suatu produk, mengakibatkan produsen berusaha untuk selalu menjaga mutu produk yang dihasilkannya. Tujuan dari penelitian ini adalah menganalisis kelayakan dasar unit pengolahan ikan kayu  (Keumamah)  yang berada di Kota Banda Aceh. Hasil penelitian menunjukkan kondisi sanitasi dan hygiene dari proses pengolahan ikan kayu tidak sesuai standart. Langkah-langkah perbaikan yaitu perhatian tentang masalah peningkatan mutu proses pengolahan ikan kayu meliputi air pencucian dan es, lokasi dan lingkungan (sarana dan prasarana), kontruksi Bangunan (lantai, ventilasi, tembok, atap, toilet, tempat cuci), peralatan dan pakaian kerja, kesehatan karyawan, bahan kimia, pembersih, saniter, syarat label dan penyimpanan serta pengendalian pest. Kata kunci : Kuemamah, GMP, SSOP
A Detection and Response Architecture for Stealthy Attacks on Cyber-Physical Systems
Authors: Shawly Tawfeeq
Published: October 2023

There has been an increased reliance on interconnected Cyber-Physical Systems (CPS) applications. This reliance has caused tremendous growth in high assurance challenges. Due to the functional interdependence between the internal systems of CPS applications, the utilities' ability to reliably provide services could be disrupted if security threats are not addressed. To address this challenge, we propose a multi-level, multi-agent detection and response architecture built on the formalisms of Hidden Markov Models (HMM) and Markov Decision Processes (MDP). We have evaluated the performance of the proposed architecture on one of the critical smart grid applications, Advanced Metering Infrastructure (AMI). This paper utilizes a simulation tool called SecAMI for performance evaluation. A Stealthy attack scenario contains multiple distinct multi-stage attacks deployed concurrently in a network to compromise the system and stop several critical services in a CPS. The results show that the proposed architecture effectively detects and responds to stealthy attack scenarios against Cyber-Physical Systems. In particular, the simulation results show that the proposed system can preserve the availability of more than 93% of the AMI network under stealthy attacks. A future study may evaluate the effectiveness of various stealthy attack strategies and detection and response systems. The high availability of any AMI should be protected against new attack techniques. The proposed system will also determine a distributed IDS's efficient placement for intrusion detection sensors and response nodes within an AMI.
Geometry Representation Effectiveness in Improving Airfoil Aerodynamic Coefficient Prediction with Convolutional Neural Network
Authors: Zikri Arizal Akbar , Defianti Hanni , Hidayat Wahyu , Purqon Acep
Published: October 2023

Many applications use symmetric or asymmetric airfoils, such as aircraft design, wind turbines, and heat transfer. Each airfoil has different aerodynamic coefficients. Obtaining the aerodynamic coefficients is a must to optimize the airfoil design. Engineers use various methods to get the airfoil aerodynamic coefficients. A prediction method is an approximation approach that effectively reduces time and cost. This article uses convolutional neural networks (CNN) to get approximation values of those coefficients. In CNN, we collect 8920 aerodynamic coefficients for 223 NACA 4 as labels in datasets by using XFOIL at Â and Â with varying angles of attacks starting Â to Â with increment of . The simulation results are compared to the experiment using E387 airfoil for validation. Then, airfoil geometries as part of input datasets were transformed into Grayscale and RGB images using the signed distance function (SDF) and mesh algorithm. Each airfoil representation was trained using an 80% dataset and tested using a 20% dataset with Adam as an optimizer to generate each prediction model using modified LeNet-5. We use three different layer depths in modified LeNet-5 to obtain the optimal layer number. There is no remarkable improvement when varying the depth layers, so four layers are used instead. Simulation results show that using an SDF with Fast Marching Method on CNN predicts the most effective for the airfoilâ€™s lift, drag, and pitch moment coefficient with varying angles of attack simultaneously. One can extend the method by using SDF to recognize different flow conditions.
The impact of an online technology course on pre-service teachers’ technological knowledge: Strategies and design
Authors: Greene Moe Debbagh , Cheng Sheng-Lun , Jones William Monty
Published: October 2023

This study investigated how pre-service teachers’ technology integration knowledge changed as a result of participating in an online educational technology course for a semester in the Fall of 2020 and the Spring of 2021. The pre-service teachers’ technology integration knowledge development was assessed through their self-reported technological pedagogical content knowledge (TPACK). A total of 194 participants completed a validated TPACK pre- and post-test survey. The results of multilevel modeling analysis suggested that the participants had significant gains in all TPACK domains. Strategies used in designing the online educational technology course were examined for their contribution to pre-service teachers’ TPACK development. Educational technology-based course included activities that facilitated the integration of the components of TPACK framework through peer interactions, lesson planning, and peer feedback. The findings have implications for future research and provide guidance for the design of effective online learning environments to improve pre-service teachers’ technology integration knowledge.
Identification of the Distribution of Asian Redtail Catfish (Hemibagrus nemurus) Based on Geographical Information Systems (GIS) in the Progo River, Magelang, Central Java
Authors: Mujtahidah Tholibah , Siswanto Usman , Hidayati Sri , Jailani Abdul Qadir
Published: October 2023

Identification of the distribution of asian redtail catfish (Hemibagrus nemurus) based on Geographical Information System (GIS) in the Progo Magelang river is a database collection process to determine the distribution patterns of H. nemurus and determine H. nemurus resources with the help of GIS and outlined in the form of a fish resource zoning map so that it can help in domestication efforts that lead to the cultivation of endemic aquatic commodities. The purpose of this study was to identify the distribution of H. nemurus, determine the status of H. nemurus resources based on diversity data to see the existing potential and to describe it in the form of a fish resource zoning map in the progo river. The research method used was a survey method with a GIS approach and the data presented in the form of descriptive analysis included fish identification and a GIS approach. GIS data processing used is in the form of hardware, namely: Personal Computer (PC), color printer and scanner, while the software in the form of software ArcGIS 9.x, Ms. Excel and Ms. Word. The method used in this study is the GIS approach with spatial analysis techniques, namely the techniques used in analyzing spatial / spatial studies. Based on the results of the study, it was shown that H. nemurus in the Progo river were found in areas with sandy clay substrates at a depth of 2 m, namely in the Ngeluwar area. The distribution of H. nemurus in the Progo river tends to be evenly distributed, because the conditions of the Progo river habitat support the life of H. nemurus.Keywords: Hemibagrus nemurus, Geographical Information System, Progo River.
Alcolic liver disease: what’s new in the current decade?
Authors: Trukhan D. I.
Published: October 2023

Alcoholic liver disease (ALD) - damage to the liver parenchyma under the influence of ethanol consumption, which can manifest itself in several ways: steatosis, alcoholic hepatitis (steatohepatitis), fibrosis and cirrhosis of the liver. The present review considers publications of recent years (2020-2023) in the Pubmed and Scopus information databases devoted to the study of various aspects of the current state of the problem of alcohol-associated liver pathology. New data on the epidemiology and burden of ALD have been obtained; the pandemic of a new coronavirus infection has had a certain impact on the course of ALD. The study of individual links in the pathogenesis of ALD is actively continuing, a large number of publications are devoted to the participation and role in the pathogenesis of alcohol-associated liver diseases of the “gut-liver” axis. New therapeutic strategies for alcohol-associated liver disease are classified based on their mode of action: (1) anti-inflammatory therapies, (2) antioxidants, (3) therapies that modulate the gut-liver axis, and (4) therapies that enhance liver regeneration. At the same time, the often unfavorable prognosis and insufficient effectiveness of therapy require further study of alcohol-associated liver diseases.
Steatotic liver disease - an international interpretation of the concept an “umbrella” for all diseases of the hepatic parenchyma
Authors: Lazebnik L. B.
Published: October 2023

The international working group “Multi-Society and Multi-Stakeholder Consensus Revision of the NAFLD Nomenclature” proposed to replace the widely used term NAFLD - Non-alcoholic fatty liver disease with SLD - Steatotic Liver Disease - Steatous Liver Disease, using it in the form of an “umbrella” to include in this concept Metabolic and Alcoholic liver disease, its drug lesions and severe systemic diseases of the hepatic parenchyma.
Unggul dalam Kepelatihan Cabang Olahraga, Pendidikan Jasmani dan Manajemen Olahraga
Authors: Wijayanto Adi
Published: October 2023

Buku ini diharapkan dapat memberi warna dan bisasebagai pedoman dalam menambah ilmu pengetahuan karena didalam pembahasannya terdapat berbagai pemikiran dari para ahli maupun dari pihak yang sudah menguasai keilmuan yang sesuai dengan tema pembahasannya masing-masing. tentunya didalam buku ini menggunakan kata atau narasi yang ringan dan mudah dipahami. Buku ini membahas mengenai berbagai teori-teori tentang pentingnya kesehatan jasmani, berbagai macam cabang olahraga yang sering di perlombakan dan juga pengelolaan didalam penyelenggaraaan suatu event olahraga baik yang dari tingkat dasar hingga internasional.
Characterization and removal of microplastics in Guheshwori wastewater treatment plant in Nepal
Authors: Bastakoti Smriti , Adhikari Asmita , Thaiba Bishan Man , Neupane Bhanu Bhakta , Gautam Bhoj Raj , Dangi Mohan B. , Giri Basant
Published: October 2023

Contamination of river water systems by microplastic particles (MPPs) is one of the emerging global environmental concerns with potentially widespread ecological, socioeconomic, and health implications. Wastewater treatment plant (WWTP) processes and treats wastewater to remove pollutants and release safe water into the environment. There has been limited research on the characterization of microplastics and their removal at a WWTP in South Asia. In this work, we report on the characterization of microplastics in wastewater and sludge samples (n=300) from Guheshwori WWTP located on the bank of the Bagmati River in Kathmandu representing inlet, secondary aeration tank (SAT), outlet, and sludge from November 2021 to November 2022. On average, we detected 31.2±17.3 MPPs/L, 11.2±9.4 MPPs/L, 7.0±5.6 MPPs/L, and 6.6±4.8 MPPs/g in the samples collected from inlet, SAT, outlet, and sludge, respectively. Commonly found MPPs were in the form of fiber, fragment, foam, and pellet. Largely, MPPs were red, yellow, white, blue, and black in color. The most dominant size fractions were 500 µm – 150 µm in inlet, SAT, and sludge, and 150 µm – 44 µm in the outlet sampling unit. The Guheshwori WWTP was able to remove 77.5% MPPs on average, that mostly occurred in the inlet. The effluent released into the river and the sludge still contained a significant number of microplastics particles.
Ilmu Pengetahuan dan Pedagogi dalam Terapan serta Teknologi
Authors: Wijayanto Adi
Published: October 2023

Penguasaan ilmu pengetahuan dan pedagogi memberisokongan yang besar bagi guru untuk menjalankan prosedur kerja yang berkualitas dalam pembelajaran dimulai dari prosedur perencanaan, menjalankan proses pembelajaran sampai melakukan evaluasi dan penilaian atas hasil pembelajaran. Kualitas pembelajaran semakin berkembang tahap demi tahap sejalan dengan terbentuknya pengalamanpengalaman baik yang berhasil dimaknai guru. Proses itu sendiri semakin memperkokoh kemampuan atau kompetensi teknis guru yang terus meningkat secara berkelanjutan seiring dengan kemajuan teknologi saat ini
Fables of the Kingfisher
Authors: Nguyen Minh-Hoang
Published: October 2023

The book by interdisciplinary researcher in economics and social sciences Vuong Quan Hoang includes 25 stories, released in the form of an e-book and print book in English on Amazon. The Kingfisher Story Collection by author Vuong Quan Hoang expresses his observations and reflections on cultural, social, and human aspects through his perspective and experiences. Kingfisher, the main character of the whole story, to the bustling life in the bird village. It can be said that the book provides young readers with lessons on how to be human through the fun, lively, and colorful nature of birds. For older people with some or more experience, the book can provide moments of entertainment and valuable opportunities for reflection. If you read the book many times and read it from many different angles, the reader will discover even more interesting things hidden in the world of bird life
Lord Rama Devotees Algorithm: A New Human-Inspired Metaheuristic Optimization Algorithm
Authors: Gajawada Satish
Published: October 2023

Several Human-Inspired Metaheuristic Optimization Algorithms were proposed in literature. But the concept of Devotees-Inspired Metaheuristic Optimization Algorithms is not yet explored. In this article, Lord Rama Devotees Algorithm (LRDA) is proposed which is a new Devotees-Inspired Metaheuristic Optimization Algorithm.
The Heavy Mineral Map of Australia Project: A Novel, Rapid, Automated Quantitative Mineralogy Workflow
Authors: Walker Alexander , McInnes Brent , de Caritat Patrice , Bastrakov Evgeniy
Published: October 2023

The Heavy Mineral Map of Australia (HMMA) is the world’s first project aiming to define acontinental heavy mineral baseline. It utilises a novel sample processing workflow andautomated mineralogy techniques to rapidly generate and analyse mineralogical data from1315 archived samples of catchment outlet sediments collected from 1186 catchmentsacross the Australian continent.Heavy minerals were extracted and concentrated from the 75–425 μm fraction of eachsample via an optimised workflow to accelerate output while maintaining integrity and quality of produced heavy mineral concentrates. Automated mineralogy facilitated rapid and consistent collection of mineral data from each heavy mineral concentrate, and anassociated bespoke mineral library incorporates more than 160 unique mineral phases,including minerals that will be of interest to both researchers and mineral explorers. Apublicly accessible mineral network analysis application has been developed in parallel with the HMMA project to facilitate exploration and interpretation of the resulting >140 million mineral grain identifications dataset.Upon completion in late 2023 the HMMA will provide a heavy mineral baseline acrossapproximately 80% of Australia, with processing of samples and data acquisition undertaken in a standardised and uniform manner enabling easy replication of techniques and both internal and external comparability.
Approaching coherent turbulence and the roll-cell transition with Lagrangian coherent structures and objective fluxes
Authors: Aksamit Nikolas , Katurji Marwan , Zhang Jiawei
Published: October 2023

We present the first analysis of objective and material vortices in Large Eddy Simulations of atmospheric boundary layer turbulence. We extract rotating fluid features that maintain structural coherence over time for near-neutral, transitional, and convective boundary layers. In contrast to traditional analysis of coherent structures in turbulent boundary layers, we provide the first objective (frame-indifferent) identification of temporally coherent vortex boundaries that are responsible for organizing tracer distributions. We compare these rotating structures with qualitative descriptions of horizontal rolls and convective cells arising from decades of observational studies. We also quantify their contribution to turbulent fluxes of heat under varying atmospheric stability. Using recently developed tools from the theory of objective transport barriers, we derive connections between the relative orthogonality of objective momentum and heat transport with the presence of rolls and cells. This suggests the relationship between momentum and heat transport through vortex surfaces may help explain the physics behind roll-cell transitions.
Field Report No. 1 - Tabor Tree Project Report 2021
Authors: gossen candace
Published: October 2023

In this Survey, the Tabor Tree Project identified 130 trees randomly in all 12 zones of the park called Mt. Tabor in Portland, Oregon. The Majority of the Trees at Mt. Tabor Park are conifers, and specifically Douglas Fir who can live longer than 1,000 years. The oldest one in the park is 496 years old, and sprouted sometime around 1520 AD. Through the efforts of Tree Medicine hikes and Citizen Science this data was collected over a year in 2021.
Rano Kao & Ava Ranga Uka: Rapa Nui Report 2014
Authors: gossen candace
Published: October 2023

29 March 2014 Objective: Sampling and testing Rano Kao water depth, evaporation and volume. Compare with previous results from 2005, 2008 and 2014 coring expeditions and detect the rate of change in lake water evaporation as compared to Global Meteoric Water Line.
Can templates-for-rejection suppress real-world affective objects in visual search?
Authors: Brown Chris Robert Harrison , Derakshan Nazanin
Published: October 2023

Previous evidence has suggested that feature-based templates-for-rejection can be maintained in working memory to suppress matching features in the environment. Currently, this effect has only been demonstrated using abstract neutral shapes, meaning that it is unclear whether this generalises to real-world images, including aversive stimuli. In the current investigation, participants searched amongst an array of real-world objects for a target, after being pre-cued with either a Distractor template, Target template, or a No template baseline. In Experiment 1, where both Distractor and Target template cues were presented randomly on a trial-by-trial basis, there was moderate evidence of increased capture by aversive distractors after the Distractor template cue. In Experiment 2a, however, when Distractor templates were the only available cue and more time was given to encode the cue features, there was moderate evidence of effective distractor inhibition for real-world aversive and neutral stimuli. In Experiment 2b, when the task required a slower more effortful comparison of target features to stereotypical object representations, there was weaker evidence of inhibition, though there was still modest evidence suggesting effective inhibition of aversive distractors. A Bayesian meta-analysis revealed that across Experiment 2, aversive distractors showed strong cumulative evidence of effective inhibition, but inconsistent inhibition for neutral distractors. The results are interpreted from a rational search behaviour framework, which suggests that individuals utilise informative cues when they enable the most beneficial strategy and are accessible, and apply these to distractors when they cause sufficient disruption, either to search speed or emotional state.
Examining the Influence of Politicians’ Emotional Appeals on Vote Choice using a Visualized Leader Choice Task
Authors: Homan Maaike , Schumacher Gijs
Published: October 2023

Do the emotional appeals of politicians affect our voting decisions? Or do these morefleeting effects of emotions disappear when taking into account individuals’ ideologicalagreement with a candidate? To test this, we present four preregistered online surveyexperiments (total N = 4,954, Obs = 57,042) conducted in the Netherlands and the US.We use an innovative Leader Choice Task, a visual conjoint experiment displaying twoelection posters simultaneously. Each election poster shows a political candidate with amanipulated emotional expression, a statement regarding different political issues withdifferent positions on that issue, using different emotional tones. Across the four studies,we find consistent evidence that people are attracted by positive emotional appeals (intone and expression) and are repulsed by negative emotional appeals. We find theseresults across different manipulations of issue agreement, issue salience, issues concerningthreat, slogans, and politicians’ facial dominance. Overall, our study shows that emotionsare influential, even when fundamental vote choice predictors such as issue position andissue salience are included.
A reply to Dr. Erik Hoel’s post regarding the overpromotion of IIT
Authors: Lee Alan L. F.
Published: October 2023

In his post on the Intrinsic Perspective, Dr. Erik Hoel argues, in response to an earlier letter signed by 124 authors regarding the integrated information theory (IIT) of consciousness, that the media have not exaggerated the empirical support for IIT. He claims that the letter "comes from some alternative reality in which IIT is taken as gospel, all the media celebrate it". The present article is a short reply arguing otherwise (and presenting the reality), with the support of a sample of 20 quotes from different articles in the media.
Precise Individual Measures of Inhibitory Control
Authors: Lee Hyejin J. , Smith Derek Martin , Hauenstein Clifford , Dworetsky Ally , Kraus Brian T. , Dorn Megan , Nee Derek , Gratton Caterina
Published: October 2023

Inhibitory control is essential to daily function and is a key factor in numerous psychiatric disorders. One popular measure of inhibitory control is the congruency effect, but recent research has highlighted its low reliability, limiting its use for clinical and basic research questions. Here, we asked whether it is possible to obtain precise individual estimates of the congruency effect. We sampled more than 5,000 trials from nine participants across four inhibitory control tasks. This dataset, made public for the community, demonstrates that precise individual estimates are achievable but with higher numbers of trials than typically collected with common tools. Using a combination of datasets and simulations, we show that extensive sampling is necessary to reveal true individual differences and improve observations from alternative modeling approaches. We share our dataset as a resource to further understand sources of variation in inhibitory control, ultimately advancing research in this critical field.
Prevalence and impact of falls as domestic injury among rural housewives of Raipur District, Chhattisgarh, India
Authors: Mondal Jaita , Singh Maharaj
Published: October 2023

Introduction: The most common domestic injury among housewives is falling from stairs and ramps or on the floor. The present study aimed to find and associate the prevalence of falls with various agents, risk factors causing falls and the impact of falls among rural housewives.
Methods: A cross-sectional survey was carried out among 500 randomly selected housewives from rural areas of Raipur district, Chhattisgarh in the month of March to June 2019. Demographic data and information regarding the occurrence of falls, various agents & factors associated with falls were collected by questionnaires, lux meter, anemometer and sound level meter through interviews, and observation techniques. The Nordic questionnaire was used to assess the impact of falls. Collected data were analyzed by using SPSS 20 statistical package.
Results: 295 out of 500 housewives had domestic injuries which included 12.8 % of fall injuries. Fall had a significant association with various physical agents like illumination in the living room (χ2=11.004, df=1), relative humidity of the kitchen (χ2=18.03, df=2) and presence of adequate natural light (χ2=11.232, df=1). Even various personal risk factors were significant causes of falls like wearing slippers on a wet floor (χ2=11.845, df=1), presence of open electric wires (χ2=4.84, df=1), self-cleaning of toilet & floor (χ2=11.371, df=1) and self-cooking (χ2=10.959, df=1). Heavy works like carrying water in a big container (χ2=6.025, df=1), working under direct sunlight (χ2=4.195, df=1), prolonged standing while cooking or on an agricultural field (χ2=32.073, df=1) and using of hand pump per day to draw water (χ2=42.329, df=1) were highly significant causes of domestic fall.
Conclusion: Findings of the study concluded that fall was very much prevalent among housewives, and being at home still housewives are exposed to various agents and personal risk factors causing fall.
Assessment of Knowledge, Attitude, and Practices of Personal Protective Equipment among Health Care Providers in Tamil Nadu, South India
Authors: Lavanya Dominic Savio , Sony Paul , Kannan Iyanar , Thenmozhivalli PR
Published: October 2023

Introduction: Personal protective equipment provides considerable protection from hospital-acquired infections. Ample knowledge with a positive attitude and best practices of personal protective equipment by healthcare workers is indispensable to get protection themselves and to serve humanity. The study aimed to assess the knowledge, attitude, and practice (KAP) regarding personal protective equipment (PPE) among healthcare workers along with possible determinant factors.
Methods: An observational cross-sectional study was conducted from August - September 2022 among 386 healthcare workers in Tamil Nadu, South India. The structured self-administered questionnaire was used for data collection. The study comprised questions evaluating a socio-demographic profile, knowledge, attitude, and practice of personal protective equipment. Descriptive statistics (percentage, frequency, mean) and inferential statistics (Chi-square test) were used for the data analysis.
Results: The overall knowledge of the participants was satisfactory (73.3%). Physicians had a good knowledge level against non-physicians (p<0.05). It was observed that the 30 and more years of experience group has less knowledge (p<0.05). A positive attitude toward PPE was noted in 58.3% of the participants. Statistical significance in the attitude of participants with education, occupation, and experience was not observed (p>0.05). Good practice of PPE was followed by 66.8% of participants. Nurses(91.7%) showed good practice of PPE than physicians and laboratory technicians and was found to be statistically significant (p<0.05).
Conclusion: The findings demonstrated that most healthcare workers had an overall good knowledge, positive attitude, and good practice regarding PPE however they need periodical training and auditing.