bluuebunny/crossref_metadata_2025 huggingface dataset:
Об образе волка в калмыцких сказках
Authors:   Kalmyk Scientific Center of the RAS (8, Ilishkin St., 358000 Elista, Russian Federation), Chumbaeva Anna S. , Bakaeva Elza P.
Published: January 2024

The purpose of the article is to consider the features of the image of the wolf in Kalmyk fairy tales. The research material was both published and unpublished texts of Kalmyk fairy tales in the original and translated into Russian. Results. Based on the conducted research, it can be concluded that there is a common understanding of the wolf in the culture of the Mongolian peoples, including the Kalmyks. The image of the wolf in Kalmyk fairy tales is multifaceted, ambivalent, due to the variety of qualities inherent in this animal, with the main symbolic meanings used to characterize the wolf in folklore. The ideas about the wolf in the Kalmyk culture are determined by both the ontological characteristics of the animal a s well as its cultural characteristics. Along with the ideas that are defined by its characteristics as a predator, in the culture of the Kalmyks the wolf is revered as a totemic animal that is indirectly reflected in the fairy tales where the wolf is endowed with wisdom and is presented as a leader.
Обзор материалов фонда Р-145 Национального архива Республики Калмыкии — личного фонда профессора Н. Н. Пальмова
Authors:   Kalmyk Scientific Center of the RAS (8, Ilishkin St., 358000 Elista, Russian Federation), Batmaev Maksim M.
Published: January 2024

Introduction. N. N. Palmov, the founder of the archives of Kalmykia, one of the first researchers of the history of Kalmykia during the Soviet period, made a huge contribution to the formation and development of historical science and archival affairs of Kalmykia. The purpose of the article is to give an overview of the affairs of the personal fund of Professor N. N. Palmov, stored in the National Archive of the Republic of Kalmykia. Results. The article presents an overview of the cases included in the personal fund of N. N. Palmov. It is noted that a significant place in the R-145 fund is occupied by information about land problems, about the economic activities of the Kalmyks and about social problems. There are materials on plans for the reconstruction of public life, on the living conditions of the Kalmyk population. Often, the cases of the R-145 foundation are complex in nature — a variety of data included in one case show the process of N. N. Palmov’s research work. Conclusions. The R-145 Fund of the National Archive of the Republic of Kalmykia contains materials that expand the source base of those engaged in the study of Kalmyk history. The case files of this foundation add new positive touches to the image of N. N. Palmov as a historian and just a person.
Личное учетное дело спецпереселенца (выселенца) как исторический источник по изучению депортации калмыцкого народа
Authors:   Kalmyk Scientific Center of  the RAS (8, Ilishkin St., 358000 Elista, Russian Federation), Vaskina Angelika Yu. , Kukanova Viktoria V.
Published: January 2024

Introduction. This article is devoted to a source-based analysis of the personal records of special settlers (evictees) of Kalmyks who were in forced exile in the eastern regions of the country. Without taking into account the content of these archival materials, the research on the life of Kalmyks in exile without the right to return to their former place of residence seems incomplete and unrepresentative, despite the existing wide range of historical sources. To fill this gap, the article analyzes this source based on the material of the personal records of special settlers (evictees) — Kalmyks who lived during exile on the Altai Territory. The purpose of this study is to study the composition and content of documents related to the personal account of a special settler. Results. The personal record of the special settler (evictee) is a valuable, unique and representative historical source, the informative possibilities of which are still not really in demand by researchers who study the deportation of the Kalmyk people. This source has not been used to date in the study of the history of the deportation of the Kalmyk people in the period from 1943–1957. At the same time, the personal record of the special settler (evictee) has a high source potential, since it can be used as the main source for compiling a prosopographic portrait of the special settler-Kalmyk. In addition, this source will give an opportunity to characterize the features of demographic and migration processes of Kalmyk special settlers during the period of exile.
Craniectomía descompresiva en infarto de arteria cerebral media bilateral asociado a
COVID-19. Reporte de caso
Authors: Flores-Maya Marco Antonio , Vázquez-Nieves José Roberto , Arroyo-Zavala Octavio Jesús , Laredo-Gómez Jenner
Published: January 2024

The new severe acute respiratory syndrome due to coronavirus type 2 (SARS-CoV-2), which causes COVID-19 disease, was detected for the first time in December 2019. Where it has been seen that there is a prothrombotic state with involvement of the Central Nervous, with involvement of large vessels such as the middle cerebral artery, is due to mechanisms induced by the infection itself, hypercoagulable state and endothelial damage. Neurological manifestations in COVID-19 are found in 36% of patients. Case description: This is a 36-year-old male patient with fever, cough and general malaise. A COVID test was performed, which came out positive. His condition was getting worse adding photophobia, right hemiparesis and deviation of the corner of the mouth to the left, which is why he went to the doctor, arriving 8 hours after the onset of the clinical picture, where a simple skull tomography was performed, showing extensive infarction of the left middle cerebral artery with malignant cerebral edema. He was transferred to emergency surgical management where a left decompressive craniectomy was performed. After this, mechanical respiratory assistance with intubation and anti-cerebral edema measures were maintained, achieving ventilatory progression; however, a tracheostomy and gastrostomy were performed due to poor predictors of extubation. He was kept under post-surgical observation, leaving him with 3/5 right hemiparesis, without any other deficit, therefore, he was discharged home. Discussion: The case presented was managed with decompressive craniectomy, resulting in an improvement in survival, as reported in the literature where it is recommended that such management should be performed early. Conclusions: This report reveals that patients with COVID-19 present in young men in the fourth and fifth decade of life, without comorbidities, that recieved early treatment with decompressive hemicraniectomy, improved their life prognosis, consistent with the cases presented in the literature. Keywords: COVID-19; brain infarction; decompressive craniectomy; hypercoagulability.
PENGARUH UTANG TERHADAP PEREKONOMIAN NASIONAL (PERTUMBUHAN EKONOMI, KEMISKINAN, DAN PENGANGGURAN)
Authors: Pratiwi Dwi Resti , Dahiri
Published: January 2024

Debt is the part of the government's fiscal policy which also being the part of the financial management policy. The financial management itself aims to improve people's welfare through the increase of economic growth, poverty reduction, and job creation. The purpose of this study is to analyse the impact of government debt on national economy including economic growth, proverty and unemployment rate. The study used data series of Indonesian economy including government debt, economic growth, poverty level and unemployment rate data from 2000 to 2016. The analytical method used was Granger causality and regression analysis. The result shows that there is a positive relationship between government debt and economic growth.
Analisis Daya Saing Industri Tekstil dan Produk Tekstil (TPT) Indonesia Di Pasar ASEAN
Authors: Pratiwi Dwi Resti
Published: January 2024

Indonesia adalah salah satu dari 15 negara penghasil tekstil & pakaian jadi teratas di dunia dan karenanya juga merupakan salah satu produsen tekstil terbesar di Pasar ASEAN. Penelitian ini mengkaji daya saing TPT Indonesia di pasar ASEAN dengan menggunakan metode RCA dan menganalisis faktor determinan daya saingnya dengan menggunakan metode regresi ordinary least square (OLS). Periode penelitian dari tahun 2000-2019. Berdasarkan perhitungan tingkat daya saing dengan menggunakan RCA, menunjukkan bahwa industri TPT Indonesia memiliki daya saing yang kuat (RCA>1) di pasar ASEAN selama tahun 2000-2005. Namun pada tahun-tahun berikutnya, daya saingnya menurun hingga di bawah 1 poin. Jadi, TPT Indonesia tidak memiliki daya saing yang kuat selama 2006-2019. Faktor-faktor yang mempengaruhi daya saing Industri TPT Indonesia adalah harga ekspor, REER, dan investasi. Pemerintah perlu lebih serius mengidentifikasi dan mengatasi faktor-faktor yang menghambat daya saing industri TPT.
Pengaruh Pengeluaran Pemerintah Di Bidang Subsidi, Pendidikan, dan Kesehatan Terhadap Kemiskinan
Authors: Carolina Martha
Published: January 2024

Masalah kemiskinan terkait dengan aspek lain seperti kesehatan, pendidikan, sosial, ekonomi, budaya, dan aspek lainnya. Aspek pengeluaran merupakan aspek yang krusial bagi pemerintah karena besaran pengeluaran ditentukan langsung oleh pemerintah dan pada akhirnya dapat mempengaruhi angka kemiskinan. Berdasarkan hal tersebut di atas, penelitian ini akan membahas dampak pengeluaran pemerintah untuk pendidikan, kesehatan, dan subsidi terhadap kemiskinan di Indonesia. Data yang digunakan dalam penelitian ini adalah data sekunder berupa periode tahunan dari tahun 1992 sampai dengan tahun 2020. Penelitian ini menggunakan pendekatan kuantitatif dengan metode regresi. Variabel subsidi (X1) berpengaruh terhadap kemiskinan (Y). Ketika subsidi meningkat, kemiskinan meningkat. Hasil ini menunjukkan bahwa anggaran subsidi yang diberikan oleh pemerintah kurang tepat sasaran untuk mengurangi kemiskinan. Pengeluaran pemerintah untuk pendidikan (x2) berpengaruh terhadap kemiskinan (Y). Ketika pengeluaran pendidikan meningkat, kemiskinan menurun. Pengeluaran pemerintah bidang kesehatan (X3) tidak berpengaruh terhadap kemiskinan (Y).
MENINJAU IMPLEMENTASI KEBIJAKAN PUBLIC SERVICE OBLIGATION DI SEKTOR TRANSPORTASI
Authors: Paramita Rastri
Published: January 2024

Penelitian ini bertujuan untuk mengedukasi masyarakat tentang dasar pelaksanaan PSO, bentuk pelaksanaan PSO, dan perbedaan pelaksanaan PSO oleh BUMN sektor transportasi, dengan contoh pelaksanaan PSO di PT Pelni dan PT KAI. Hal ini dimaksudkan agar dengan memahami variasi implementasi PSO oleh BUMN, dapat memberikan saran perbaikan implementasi PSO ke depan. Hasil kajian tentang PSO di PT KAI dan PT Pelni dari jurnal, penelitian, dan media digunakan dalam penelitian ini, yang menggunakan metodologi kualitatif dan data sekunder berupa data perundang-undangan, data pembangunan, dan pelaksanaan PSO. Akibatnya, terdapat ketidaksesuaian dalam pelaksanaan teknologi PSO untuk penyediaan jasa transportasi di Indonesia. Perbedaan ini menjadikan peran PSO tidak hanya sebagai instrumen pemerintah untuk memberikan transportasi yang terjangkau bagi masyarakat, terutama masyarakat miskin, tetapi juga sebagai tujuan lain untuk hadir.
UPAYA PENGUMPULAN PAJAK (TAX EFFORT) SEBELUM DAN SAAT PANDEMI COVID-19 DI INDONESIA
Authors: Aida Ade Nurul
Published: January 2024

Studi ini menganalisis kondisi upaya perpajakan di Indonesia sebelum dan selama pandemi Covid-19 di Indonesia. Data yang digunakan dalam kurun waktu 4 tahun yaitu sebelum dan selama pandemi Covid-19 dari tahun 2018 sampai dengan tahun 2021. Teknik analisis data menggunakan alat analisis uji sampel berpasangan T-Test atau Wilcoxon Non Parametric Test karena penelitian ini dilakukan dengan membandingkan sampel penelitian upaya perpajakan sebelum dan selama Covid-19. Hasil uji empiris menunjukkan bahwa tidak ada perbedaan yang signifikan antara upaya perpajakan sebelum pandemi dan selama pandemi. Meski kondisi perekonomian masih rentan dan belum sepenuhnya stabil, pemerintah tetap harus meningkatkan upaya perpajakannya secara tepat. Upaya perpajakan yang rendah tentunya dapat berimplikasi pada penerimaan negara (terutama dari pajak) dalam pembiayaan pembangunan daerah itu sendiri.
ANALISIS EMPIRIS PRODUKSI KELAPA SAWIT TERHADAP TINGKAT KESEJAHTERAAN PETANI
Authors: Hidayatullah Taufiq
Published: January 2024

Meskipun produksi sawit rakyat dan harga CPO cenderung meningkat, namun kesejahteraan petani tidak sejalan dengan peningkatan tersebut. Penelitian ini bertujuan untuk menganalisis, pertama, pengaruh luas lahan dan produktivitas kelapa sawit terhadap produksi kelapa sawit. Kedua, pengaruh produksi kelapa sawit dan harga CPO terhadap kesejahteraan petani. Data yang digunakan dalam penelitian ini adalah data sekunder yang bersumber dari BPS. Sedangkan metode analisis datanya menggunakan regresi berganda dengan fungsi produksi Cobb-Douglas. Hasil penelitian menunjukkan bahwa pertama, luas lahan dan produktivitas berpengaruh positif terhadap produksi kelapa sawit. Lahan dan produktivitas saling menguatkan, masing-masing menyumbang peningkatan produksi sebesar 1 persen. Kedua, produksi kelapa sawit dan harga CPO berpengaruh positif terhadap kesejahteraan petani. Produksi kelapa sawit dan harga CPO merupakan dua hal yang saling menunjang kesejahteraan petani, masing-masing memberikan kontribusi terhadap peningkatan kesejahteraan petani sebesar 0,22 persen dan 0,34 persen.
PENGARUH ANGGARAN PARIWISATA TERHADAP PRODUK DOMESTIK BRUTO, TENAGA KERJA, DAN DEVISA PARIWISATA
Authors: Bangun Ollani Vabiola , Wulandari Savitri , Ananto Eko , Iranisa
Published: January 2024

Meskipun anggaran pariwisata merupakan yang terendah dibandingkan belanja fungsional nasional lainnya, namun hal ini diharapkan dapat memberikan dampak positif terhadap perekonomian nasional dan daerah tujuan wisata. Kontribusi tersebut dapat tercermin pada PDB, devisa pariwisata, dan lapangan kerja. Untuk mengetahui seberapa besar pengaruhnya, tulisan ini bertujuan untuk menganalisis pengaruh anggaran pariwisata terhadap perekonomian nasional. Penelitian ini menggunakan metode kuantitatif dengan model regresi. Hasil penelitian menunjukkan bahwa anggaran sektor pariwisata mempunyai implikasi positif dan signifikan terhadap PDB pariwisata, devisa pariwisata, dan tenaga kerja di sektor pariwisata. Setiap kenaikan anggaran sektor pariwisata sebesar Rp1 miliar diperkirakan menghasilkan PDB sebesar Rp355.005,30 miliar dan devisa sebesar USD751,12 serta menambah jumlah tenaga kerja sebanyak 543 orang. Oleh karena itu, disarankan agar pemerintah meningkatkan alokasi anggaran sektor pariwisata agar sektor pariwisata dapat memberikan kontribusi yang lebih besar terhadap pertumbuhan perekonomian nasional.
KORUPSI DAN PENANAMAN MODAL ASING: PERBAIKAN KELEMBAGAAN
Authors: Christianingrum Ratna
Published: January 2024

Para sarjana telah mempelajari dampak korupsi terhadap investasi asing langsung (FDI). Beberapa penelitian memberikan bukti adanya hubungan negatif antara korupsi dan penanaman modal asing, sementara penelitian lainnya tidak menemukan hubungan yang signifikan. Studi ini mengkaji dampak korupsi terhadap FDI di Indonesia. Data yang digunakan dalam penelitian ini adalah indeks persepsi korupsi dari Transparency International dan FDI untuk Indonesia dari CEIC. Data tersebut akan dianalisis menggunakan metode regresi untuk memperkirakan dampak korupsi terhadap FDI. Penelitian ini menunjukkan bahwa indeks persepsi korupsi (CPI) berpengaruh signifikan dan negatif terhadap FDI di Indonesia. Tingkat CPI yang rendah berarti tingkat korupsi yang tinggi. Temuan penelitian ini mendukung hipotesis “lumasi roda”. Korupsi bisa menjadi ‘minyak roda’ percepatan ekspansi ekonomi di Indonesia. Kondisi ini bukanlah hal yang baik. Oleh karena itu, diperlukan perbaikan kelembagaan untuk mengurangi praktik korupsi. Hal ini mencakup pengurangan prosedur perizinan dan perbaikan sistem pengawasan. Dukungan anggaran diperlukan.
ANALISIS KAUSALITAS GRANGER PERTUMBUHAN EKONOMI, UTANG LUAR NEGERI, KEMISKINAN, DAN PENGANGGURAN TERBUKA
Authors: Carolina Martha
Published: January 2024

Penelitian ini menganalisis hubungan kausalitas antara pertumbuhan ekonomi Indonesia, utang luar negeri, pengangguran, dan tingkat kemiskinan. Data yang digunakan adalah data time series dengan periode penelitian 1984-2022. Analisis yang digunakan dalam penelitian ini adalah metode analisis deskriptif kuantitatif dengan menggunakan uji analisis Granger. Berdasarkan hasil uji kausalitas Granger dapat disimpulkan bahwa terdapat kausalitas Granger yang searah dari tingkat kemiskinan terhadap pertumbuhan, tidak terdapat kausalitas Granger yang bersifat dua arah antara utang luar negeri dengan pertumbuhan, terdapat kausalitas Granger yang searah dari pengangguran terbuka. terhadap tingkat kemiskinan, terdapat kausalitas Granger yang searah dari tingkat kemiskinan terhadap utang luar negeri, dan terdapat kausalitas Granger yang searah dari tingkat pengangguran terbuka terhadap utang luar negeri.
GRAIN PRICE IMPLIKASI HARGA GABAH TERHADAP KESEJAHTERAAN PETANI TANAMAN PANGAN DAN INFLASI
Authors: Kusumawardhani Rosalina Tineke , Octavia Emillia
Published: January 2024

Rendahnya tingkat kesejahteraan petani tanaman pangan berpotensi mengancam ketersediaan sumber daya manusia, akibat ancaman konversi komoditas. Akibatnya, ada potensi inflasi akibat kelangkaan pangan. Oleh karena itu, makalah ini bertujuan untuk menganalisis implikasi harga gabah terhadap kesejahteraan petani tanaman pangan dan inflasi. Penelitian ini menggunakan metode kuantitatif dengan model regresi. Hasil penelitian menunjukkan bahwa pertama, gabah kering yang dipanen mempunyai implikasi positif dan signifikan terhadap kesejahteraan petani. Sedangkan gabah kering giling tidak signifikan. Kedua, gabah kering panen mempunyai implikasi positif dan signifikan terhadap harga beras, namun harga gabah kering giling tidak berpengaruh signifikan terhadap harga beras. Ketiga, harga beras mampu mempengaruhi tingkat inflasi. Oleh karena itu, pemerintah perlu melakukan upaya yaitu pertama, perlu dilakukan pengelolaan penyimpanan dan distribusi beras yang baik oleh pemerintah sehingga dapat menjaga stok dan stabilitas harga beras. Kedua, pemerintah harus mengatur distribusi tanam agar jumlah hasil panen bisa lebih merata. Ketiga, pemerintah harus meningkatkan peran petani sebagai produsen beras.
VILLAGE PERUBAHAN MASA JABATAN KEPALA DESA 6 TAHUN MENJADI 9 TAHUN: DAMPAKNYA TERHADAP KEUANGAN NEGARA DAN PENGELOLAAN DANA DESA
Authors: Rajab Achmadudin
Published: January 2024

Kemampuan kepala desa dalam mengelola keuangan masih rendah, hal ini disebabkan kurangnya pengetahuan terkait administrasi pengelolaan keuangan. Hal ini dimungkinkan karena masa jabatannya yang singkat. Oleh karena itu, tulisan ini bertujuan untuk menganalisis dampak perubahan masa jabatan kepala desa dari 6 tahun menjadi 9 tahun terhadap keuangan negara dan pengelolaan dana desa. Penelitian ini menggunakan metode kuantitatif dengan statistik deskriptif. Hasil penelitian menunjukkan bahwa pertama, masa jabatan 6 tahun menurut kepala desa kurang ideal, karena adanya permasalahan politik di desa pasca pemilihan kepala desa. Kedua, dampak perubahan masa jabatan dapat menghemat anggaran sebesar Rp17,71 triliun. Ketiga, permasalahan utama di desa adalah pendidikan, bukan masa jabatan kepala desa. Oleh karena itu, pengambil kebijakan harus memikirkan kembali penambahan masa jabatan kepala desa. Masa jabatan kepala desa harus disamakan dengan masa jabatan Presiden dan Wakil Presiden serta masa jabatan lima tahun anggota DPR, DPD, dan DPRD.
Estrategias de trading para el bono del Tesoro estadounidense usando análisis técnico y Bloomberg Professional Services
Authors: Jiménez-Méndez Édgar Ricardo , Álvarez-Lamus GKevin Gustavo
Published: January 2024

Objetivo: determinar al menos una estrategia óptima de trading aplicada al bono del Tesoro de los Estados Unidos usando análisis técnico bursátil basado en indicadores tradicionales que a diario aplican operadores del mercado en mesas de dinero.
Diseño/metodología: se aplicó un estudio de orden cuantitativo donde la información obtenida y el procesamiento de datos fueron realizados usando las funciones BT y BTST de la plataforma Bloomberg. Esta herramienta permitió realizar experimentos basados en backtesting de manera ágil. Fueron seleccionados indicadores técnicos pertenecientes a los grupos de: osciladores, volatilidad y tendencia, como MACD, RSI y bandas de Bollinger.
Resultados: se lograron identificar estrategias como la relacionada con el uso del MACD y la combinación de bandas de Bollinger con RSI, presentando esta última mejores niveles de efectividad, entendida esta como la cantidad de operaciones exitosas.
Conclusiones: a partir de este estudio se puede afirmar que las estrategias de trading diseñadas para operar bonos del Tesoro estadounidense, usando análisis técnico bursátil, en las que se incluye más de un indicador, generan mejores resultados que aquellas realizadas con uno solo de estos.
Originalidad: este estudio presenta aportes empíricos, abordados desde el análisis técnico bursátil, que ayudan a demostrar la efectividad de estrategias de trading aplicadas al bono del Tesoro estadounidense donde usualmente trabajos similares lo hacen con activos de renta variable o divisas.
The Economics of Nuclear Power
Authors: Weibezahn Jens , Steigerwald Björn
Published: January 2024

The levelized costs of electricity from renewables have decreased by up to 90% in the past decade. During the same period, the cost of nuclear power has increased by more than a third. This led to a domination of renewables in new investments worldwide. Even when factoring in integration costs of renewables and new nuclear technologies, building new nuclear power remains multiple times more expensive than new solar or wind projects. Given the financial, project, and technological risks, the role of nuclear in the energy transition should be questioned.
A Brief Economics of Energy Data Space: The EDDIE Project
Authors: Jamasb Tooraj , Giovannetti Emanuele , Llorca Manuel , Davi-Arderius Daniel , Soroush Golnoush
Published: January 2024

The appeal of decentralised approaches to structure energy generation, transmission and distribution networks, and consumption to scholars and practitioners has grown in the past 20-30 years. Moreover, in the coming years digitalisation will become a key enabler for the sustainable and efficient management of key areas in our economies including the energy sector. A European, decentralised, and open-source energy data space solution such as the one proposed in the Horizon Europe Innovation Action project EDDIE (European Distributed Data Infrastructure for Energy), fits into this trend. In this policy brief the authors outline their initial views on EDDIE and some economic concepts related to the project’s vision.
Intervention of White Spot Lesions. A Contemporary Review of 20 years
Authors: Phang Kun Mun , Sukumaran Prema , Yahya Noor Azlin , Salihu Farook Mohideen
Published: January 2024

White spot lesion is incipient caries and it manifests as white opacity lesion on the demineralised enamel surface. White spot lesions are a common adverse effect among post orthodontic patients. The prevalence of white spot lesions in post orthodontic patients varies from 2% to 97%. Therefore, it is imperative for dental practitioners to be able to manage white spot lesions. Thus, this article is a contemporary review on the management of white spot lesions. After reviewing this article, it comes to a consensus that non- invasive treatments should be the first line management of white spot lesions. Non-invasive treatments such as patient education, motivation, oral hygiene reinforcement, and attempts to remineralise with various forms of fluoride preparation should be prioritised in the treatment plan. If the white spot lesions fail to respond more invasive treatment options might be considered.
Multiple Accessory Cusps Expression at Mandibular Third Molar: A Unique Variation of Dental Crown Morphology - A Case Report
Authors: Mohamad Johar Nur Lyanna Mahfuzah , Tan Yy Jean
Published: January 2024

Accessory cusps are occasional variations in tooth morphology that can be detected clinically. Third molars have a wide range of eruption patterns and shapes but are commonly impacted. Unlike root morphology, variations in the crown morphology of the third molar have rarely been reported. Variations in crown morphology are important because they can affect clinical outcomes. Here, we present a rare case of fully erupted mandibular third molar (MTM) with multiple accessory cusps. This case report describes a case of a 31-year-old female Kenyah with a unique crown morphology of her fully erupted, vital, and functional mandibular third molar (MTM) which has multiple accessory cusps seen on the buccal surface, giving the appearance of a double tooth. Her MTM presented with an incipient caries lesion, which was managed conservatively. Documenting variations in tooth morphology is crucial for individual identification. While most people opt to have their MTMs extracted, early management of well-erupted and functional teeth should be undertaken to prevent disease progression.
Dental Anomalies and Muscle Segment Homeobox1 Gene Polymorphism in Non-syndromic Cleft Lip with or without Palate Children
Authors: B Elgali Amel Elduhrahman , Abd Rahman Normastura , Ahmad Azlina , Ghazali Norliana
Published: January 2024

This study aims to determine the prevalence of dental anomalies and MSX1 gene 799G>T polymorphism and its association with non-syndromic cleft lip with or without palate (NSCL±P) attending Hospital Universiti Sains Malaysia. Clinical and radiological assessments on 37 NSCL±P patients and 80 non-cleft children were done to detect dental anomalies. The buccal cells were collected and polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) was used to identify polymorphism. NSCL±P was higher among males (54%) and mostly unilateral cleft lip and palate (51.3%). The prevalence of dental anomalies in morphology in NSCL±P was 18.9% (95% CI: 5.7%, 32.2%) and non-cleft was 6.3% (95% CI: 0.8%, 11.7%). Hypodontia in NSCL±P was 75% (95% CI: 61.2%, 90.2%) and non-cleft was 7.5% (95% CI: 1.6%, 13.4%). There was a significant association between NSCL±P and anomalies in morphology (P= 0.04; OR=3.5)) and number (P< 0.01; OR= 40). There was an absence of rare 799G>T polymorphism in all NSCL±P and non-cleft children indicating that all samples contain common 799G polymorphism. In conclusion, the prevalence of dental anomalies in morphology and number was significantly higher in NSCL±P compared to non-cleft children. However, it was not significantly associated with MSX1 799G>T polymorphism.
Factors impacting the public social insurance scheme: The developing market study
Authors: Xhaferri Shqipe , Sotirofski Ilindena , Demi Albana , Lika Daniela , Domi Flutura
Published: January 2024

This research deals with the performance and factors of the social insurance system in Albania, which is of great importance for the economy to analyze, and the pension system that is subject to Albania’s government policies that can change over time. The purpose of this research is to analyze the relationship between social entrepreneurship and the social environment by analyzing public revenue, expenditure, fiscal policy, and the changes in minimum and maximum wages of public social contributions in Albania for the period 1999–2020. The authors find that public pension system variables such as income, expenditure, and minimum/maximum wage follow a normal distribution and their respective p-values are greater than 0.05, and income has an impact on public pension expenditure. For this study, the linear model is used, and the statistical tests used to obtain the required results are Kolmogorov–Smirnov and Shapiro–Wilk, and the correlation coefficient (r = 0.986) indicates that there is a strong positive relationship between them. The results are useful for Albanian politicians to manage the public welfare system geared towards social entrepreneurship and encourage the authors to proceed with the analysis of other financial instruments related to this system.
ISLAMIC APPROACHES TO THE ENVIRONMENTAL PRESERVATION: A SYSTEMATIC LITERATURE REVIEW
Authors: Zulkifli  , Nuryaman  , Hafidhoh
Published: January 2024

This study aims to investigate and review the Islamic perspective on the environment, identify Islamic approaches to preserve the environment and examine the effect of the Islamic approach in the empirical reality of the Muslim population. Based on a Systematic Literature Review of journal articles from the Scopus, the review results of 23 articles generated the Islamic perspective on the environment, namely the harmonious relationship of humans and the environment, the caliph’s role, the expression of faith and sharia obligations, and Islamic ethics. In preserving the environment, Islam proposes a theological approach, ethics and Sufism, Islamic law, comparative religion, educational, communication, philosophical, and social movement approaches. The review also found that while most studies demonstrate the positive effect of increasing Islamic environmental awareness, attitude, and actions, the two reveal an ineffective role of the Islamic environmental project and Islamic countries because environmental problems are subject to economic and political considerations. Future research should focus on explaining the diverse Islamic environmental perspectives and practices across different regions and cultures, fostering interdisciplinary collaboration among scholars to provide a comprehensive understanding of the topic.
Azacitidine and venetoclax for post-transplant relapse of CBFA2T3/GLIS2 childhood acute myeloid leukaemia
Authors: MISHRA AVIJEET , Mullanfiroze Khushnuma , Chiesa Robert , Vora Ajay
Published: January 2024

We report a case of 17-month-old girl who was diagnosed with
CBFA2T3/GLIS2 rearranged AMKL.Three months after a TCR αβ-CD19 depleted
haploidentical HSCT she presented with decreasing donor chimaerism,
positive flow MRD(0.2%) and more than two log rise in CBFA2T3/GLIS2
transcripts. After one cycle of azacitidine and venetoclax she achieved
molecular remission and donor chimaerism reverted to 100%. This is the
first case report of a CBFA2T3/GLIS2 rearranged AMKL responding to this
combination. This strategy, if proven to be effective in a larger
cohort, could be used to treat relapse after HSCT in this high risk
group of patients.
Nanomaterials applied in wound healing: mechanisms, limitations and perspectives
Authors: Wang Menglei , Huang Xiaowen , Zheng Huanxin , Tang Yingmei , Zeng Kang , Shao Longquan , Li Li
Published: January 2024

Internal and external factors cause various types of wounds on the skin.
Infections, nonhealing chronic wounds, and aesthetic and functional
recovery all cause challenges for clinicians. The development of
nanotechnology in biomedicine has brought many new materials, methods
and therapeutic targets for the treatment of wounds, which are believed
to have great prospects. In this work, the nanomaterials applied in
different stages to promote wound healing and systematically expounded
their mechanisms were reviewed. Then, the difficulties and defects of
the present research and suggested methods for improvement were pointed
out. Moreover, based on the current application status of nanomaterials
in wound treatment, some new ideas for subsequent studies were proposed
and the feasibility of intelligent healing by real-time monitoring,
precision regulation, and signal transmission between electronic signals
and human nerve signals in the future were discussed. This review will
provide valuable directions and spark new thoughts for researchers.
Heterogeneity of cockroach allergen-specific T cell responses in allergic sensitized children
Authors: Antunes Ricardo da Silva , Sutherland Aaron , Frazier April , Schulten Veronique , Pomés Anna , Glesner Jill , Calatroni Agustin , Altman Matthew , Wood Robert A. , O'Connor George , Pongracic Jackie , Hershey Gurjit Khurana , Kercsmar Carolyn , Gruchalla Rebecca , Gill Michelle , Liu Andrew , Zoratti Edward , Kattan Meyer , Busse Paula , Bacharier Leonard , Teach Stephen , Wheatley Lisa , Togias Alkis , Busse William , Jackson Daniel , Sette Alessandro
Published: January 2024

BACKGROUND: Characterization of allergic responses to cockroach (CR), a
common aeroallergen associated with asthma, has focused mainly on IgE
reactivity, but little is known about T cell responses, particularly in
children. We conducted a functional evaluation of CR allergen-specific T
cell reactivity in a cohort of CR allergic children with asthma.
METHODS: Peripheral blood mononuclear cells (PBMCs) were obtained from
71 children, with mild-to-moderate asthma who were enrolled in a CR
immunotherapy (IT) clinical trial, prior to treatment initiation. PBMC
were stimulated with peptide pools derived from 11 CR allergens, and
CD4+ T cell responses assessed by intracellular cytokine staining.
RESULTS: Highly heterogeneous responses in T cell reactivity were
observed among participants, both in terms of the magnitude of cytokine
response and allergen immunodominance. Reactivity against Bla g 9 and
Bla g 5 was most frequent. The phenotype of the T cell response was
dominated by IL-4 production and a Th2 polarized profile in 54.9% of
participants, but IFN production and Th1 polarization was observed in
25.3% of the participants. The numbers of regulatory CD4+ T cells were
also highly variable and the magnitude of effector responses and Th2
polarization were positively correlated with serum IgE levels specific
to a clinical CR extract. CONCLUSIONS: Our results demonstrate that in
children with mild-to-moderate asthma, CR-specific T cell responses
display a wide range of magnitude, allergen dominance, and polarization.
These results will enable examination of whether any of the variables
measured are affected by IT and/or are predictive of clinical outcomes.
Chlorogenic acid mediates JAK-STAT1 and NF-κB pathways to promote M1 phenotype polarization in mouse bone marrow macrophages
Authors: Wang Lu , Yu Jiuwang , Dong Zhiheng , Li Sha , Bao Lidao , Wu Lan
Published: January 2024

Purpose: The aim of this study was to investigate the mechanism of the
polarization response of CGA on mouse bone marrow-derived macrophages
(BMDMs) towards the M1 phenotype in an in vitro model and to verify
whether JAK-STAT1 and NF-κB are involved in the CGA induced polarization
response of M1 macrophages. Results: The purity of F4/80 in BMDMs was
>90% as determined by flow cytometry, and CGA
significantly promoted the expression of MCHⅡ，CD80andCD86 molecules on
the surface of BMDMs， upregulated the expression of M1 macrophage
marker CCR7 (C-C chemokine receptor type7) (P < 0.05) and
decreased the expression of M2 macrophage marker CD206. The expression
of TNF-α, IL-6 and IL-12 mRNA was significantly increased in CGA treated
BMDMs compared to the control group，while the expression of
CD206，Chil3，IL-10 and Arg1 mRNA was significantly decreased (P
< 0.05). 6 and IL-12 in BMDMs (P < 0.05)； In an in
vitro bacterial phagocytosis and killing assay， CGA increased the
uptake of FITC-Dextran by BMDMs and decreased the number of bacterial
survival in Escherichia coli and Staphylococcus aureus；In addition,
iNOS， NF -κBp65 and JAK-STAT1 protein expression levels were
significantly increased in BMDMs (P < 0.05). These data
suggest that CGA for M1 phenotypic polarization and expression of
associated cytokines is closely associated with activation of NF-κBp65
and JAK-STAT1. Conclusion: CGA induces polarization of BMDMs towards
M1-type macrophages and inhibits the trend towards M2-type
macrophages，which is regulated by mediating JAK-STAT1 and NF-κB
signalin
A new device for managing refractory epistaxis in ICU patients with COVID19
Authors: olivier choussy , viault nicolas , Ghanem Wahib , DUBRAY-VAUTRIN Antoine , lamer Christian
Published: January 2024

Five Key points COVID 19 treatment generate nose bleeding Covid 19
treatment necessitate prone position Nasal packing is useful but
sometimes insufficient CAVI-T is a new treatment of epistaxis CAVI-T is
especially adapted to COVID patient in prone position due to its
specific form
Addition of Roxadustat to Erythropoiesis-stimulating Agent (ESA) Effectively Corrects ESA-hyporesponsive Anemia in Peritoneal Dialysis Patients
Authors: Dai Shuqi , Chen Yun , Hao Chuanming , Ge Xiaolin , Xie Qionghong , Shang Da , Zhu Tongying
Published: January 2024

Background Erythropoiesis-stimulating agent (ESA) hyporesponsiveness is
an important cause for the undertreatment of anemia. This study aimed to
investigate the effectiveness and safety of adding HIF-PHI (roxadustat)
to ESA for the treatment of ESA-hyporesponsive anemia in Peritoneal
Dialysis (PD) patients. Methods This was a single-center
prospective-designed study in PD patients of Huashan Hospital, Fudan
University. Patients with ESA-hyporesponsive anemia were enrolled from
January 2020 to April 2020 with a 24-week follow-up period. Patients
were added with roxadustat at a starting dose of 50 or 100 mg thrice
weekly without changing the ESA dose. Roxadustat and ESA dose
adjustments were made as needed to maintain Hb levels within 11.0–13.0
g/dL. Efficacy outcomes and safety were assessed. Results A total of
nine patients were recruited in the study. Both the cumulative
responsive rate and the maintenance rate of patients with
Hb>11g/dL were 100%. Six out of nine patients had ESA dose
reduced from 15,000 UI/week or more to 7000 IU/week or less at week 24.
No drug-related severe adverse event was reported in this study.
Conclusion The present study showed that the addition of roxadustat not
only effectively corrected anemia in patients who were resistant to ESA,
but also reduced the dose of ESA.
COVID 19 infection as a cause of COPD exacerbation in a vaccinated patient
Authors: Radosavljevic Sladjana , Andrijevic Ilija , Matijasevic Jovan , Vukoja Marija
Published: January 2024

According to a largest systematic review, COPD is a significant risk
factor for hospitalization, ICU admission and mortality in patients with
COVID-19. According to British Thoracic Society patients with severe
COPD are considered Clinically Extremely Vulnerable and should receive
COVID-19 vaccine. Pfizer’s vaccine showed significant effectiveness
against COVID-19. In our case patient had severe form of COPD
exacerbation after vaccination, which required hospitalization and the
non-invasive ventilation but without intubation and radiology verified
pneumonia.
Relationships between maternal gene polymorphisms in one carbon metabolism and adverse pregnancy outcomes: a prospective mother and child cohort study in China
Authors: Wang Shuxia , Duan Yifan , Jiang Shan , Bi Ye , Pang Xuehong , Liu Changqing , Yang Zhenyu , Lai Jianqiang
Published: January 2024

Objective: To investigate relationships between maternal genes involved
in one carbon metabolism and adverse pregnancy outcomes. Design:
Prospective mother and child cohort study Setting: Wuqiang, China
Population or Sample: Pregnant women (n=939). Methods: A structured
questionnaire was used to collect pregnancy outcomes. The maternal serum
folate concentration was measured by using Abbott Architect i2000SR
chemiluminescence analyzer in the first prenatal care visit. The type of
DNA was processed by Sequenom MassARRAY iPLEX Platform. Main Outcome
Measures: Pregnancy outcomes (PTB, LBW and SGA), DNA genotyping of
methylenetetrahydrofolate reductase (MTHFR), methionine synthase
reductase (MTRR), methionine synthase (MTR) and thymidylate synthetase
(TYMS). Results: Totally, 849 dyads of women and infants were included
in the analysis. The prevalence of PTD, LBW, and SGA were 3.76%,
1.58%, and 5.31% respectively. The average serum folate concentration
was 11.95 ng/ml and the folate deficiency rate was 0.47%. There were no
significant associations between MTHFR C677T, MTHFR A1298C, MTRR A66G,
MTR A2756G, TYMS rs3819102 alleles and PTD, LBW, SGA
(P>0.05). Conclusion: In the population with adequate
folate status and low prevalence of adverse pregnancy outcomes, MTHFR
C677T, MTHFR A1298C, MTRR A66G, MTR A2756G, TYMS rs3819102 alleles may
not be related to PTD, LBW, and SGA. Funding: Program for Healthcare
Reform from the Chinese National Health and Family Planning Commission.
Keywords: Polymorphism, MTHFR, MTR, TYMS, Preterm delivery, Low birth
weight, Small-for-gestational-age Tweetable abstract No significant
relationships were found between MTHFR, MTRR, MTR, TYMS and PTD, LBW and
SGA in the population with adequate folate status.
On admission hemoglobin and albumin; two novel factors associated with thrombosis in COVID-19 pneumonia
Authors: Sadeghi Somayeh , Nasri Peiman , Nasirian Maryam , Mirenayat Maryam Sadat , Nasri Elaheh , Toghyani Arash , Hashemi Huriyeh , Fakhim Hamed , Safaei Ali , Raofi Elham , Nemati Koorosh , Khaksar Mohammadsaeid , Keivany Elaheh
Published: January 2024

Introduction: The unrelenting storm of coronavirus disease (COVID-19)
since late 2019 has turned into a crucial health matter of the globe.
There is increasing evidence in terms of a hypercoagulable state by this
infection. Therefore, the current study aims to clarify the association
between thromboembolic events in COVID-19 and the patient, the
infection, and in-hospital related characteristics. Methods: The current
case-control study has been conducted on 243 COVID-19 pneumonia patients
(83 cases with thrombotic events and 160 controls without thrombosis) in
2020. The thrombotic events included deep venous thrombosis (DVT) (n=9),
pulmonary thromboembolism (PTE) (n=48), acute myocardial infarction
(AMI) (n=17), cerebrovascular accidents (CVA) (n=4) and arterial
thrombosis (n=5). On admission, hemodynamic parameters, on admission
laboratory assessments, mobility during hospitalization, type of
oxygenation, intensive care unit (ICU) admission requirement, duration
of ICU and hospital stay were recorded in the checklist. Results:
According to logistic regression assessment, on admission O2 saturation
(OR: 0.97, 95%CI: 0.94-0.99), hemoglobin level (OR: 0.87, 95%CI:
0.77-0.97) and albumin level (OR: 0.53, 95%CI: 0.3-0.86) were
independently correlated with thrombosis due to COVID-19. Other factors,
including demographic, infection severity, laboratory and in-hospital
characteristics, were not significantly associated with thrombotic
events. Conclusion: Based on this study’s findings, hemoglobin and
albumin levels were the independent factors associated with the
thrombotic events in COVID-19 patients.
Adverse events after Anti TNF treatment for Rheumatoid Arthritis, Psoriatic Arthritis, And Ankylosing Spondylitis. A Meta-analysis.
Authors: Li Ju , Zhang Zhongyuan , Wu Xinhua , Zhou Jie , Meng Deqian , Zhu Ping
Published: January 2024

Background: The present meta-analysis was carried out to assess the risk
of infection and other side effects after anti TNF- α use to treat
Rheumatoid Arthritis, Psoriatic Arthritis, and Ankylosing Spondylitis.
Methods: To assess the impact of anti-TNF medicines on the prevalence of
infectious adverse events (serious infections; tuberculosis;
opportunistic infections; any infection; risk of cancer), we performed a
meta-analysis. We searched PubMed, Cinahl (via Ebsco), Scopus, and Web
of Sciences databases for trials comparing anti-TNF medications to
placebo or no therapy in adult patients with rheumatoid arthritis,
psoriatic arthritis, or ankylosing spondylitis from August 2006 to
August 2020. A total of 27 articles were used for the data analysis. The
risk of bias (RoB) in included studies was evaluated using the QUADAS-2
tool. The odds ratio of these studies was used to construct the forest
plot. The random-effects model was used to pool the data. Also, the
random-effects model was used with statistical significance at a p-value
less than 0.05 to assess the risk of infections and cancer after
anti-TNF treatment. Results: The risk of developing cancer (OR=1.13;
95% CI 0.79 to 1.62; p<0.05) which is lesser than serious
infections (OR= 1.5; 95% CI 1.0257 to 2.2276; p<0.05) after
anti TNF treatment. However, the risk of developing tuberculosis
infection is highest in the patients on anti-TNF treatment (OR=3.96;
95% CI 2.87-5.45) followed by skin and soft tissue infections, i.e.
(OR= 2.4598; 95% CI 1.0481 to 5.7732; p<0.05). Conclusion:
With the growing use of TNF inhibitors in adult patients with rheumatoid
arthritis, psoriatic arthritis, and ankylosing spondylitis, it is
critical to keep track of their safety profiles using additional
resources (e.g., registries and long-term epidemiological studies). The
present meta-analysis is recent evidence which suggests that there is a
definite high risk of tuberculosis and cancer after anti-TNF treatment.
PDL1 expression on monocytes is associated with plasma cytokines in Tuberculosis and HIV
Authors: TAMENE WEGENE , Abebe Meseret , Wassie Liya , Mollalign Helina , Bauer Katrin , Kebede Amha , Marconi Vincent , Howe Rawleigh , Sack Ulrich
Published: January 2024

Introduction: PDL1 and its interaction with PD1 is implicated in immune
dysfunction in TB and HIV. The expression of PDL1 on multiple subsets of
monocytes as well as their associations with cytokines and microbial
products have not been well studies. Method HIV (n=35), TB (n=34) and
TBHIV co-infected patients (n=12), primarily treatment naïve and
apparently healthy controls (n=39) were recruited. Monocyte subsets were
evaluated for PDL1 expression by flow cytometry; plasma TNFα, IL6, IP10,
IL10 were measured by Luminex; and cytokine mRNA from purified monocytes
quantitated by qPCR. The association of PDL1 with cytokines, clinical
and microbial indices, including HIV viral load, TB smear microscopy and
TB urinary lipoarabinomannan (LAM) were assessed. Results: Monocyte
expression of PDL1 was significantly higher in TB, HIV and TBHIV
co-infected patients compared with healthy controls (p=0.0001), with the
highest levels in TBHIV co-infected patients. The highest expresser of
PDL1 was intermediate (CD14+CD16+) monocytes in all participant groups.
PDL1 moderately correlated with viral load and smear positivity in HIV
and TB respectively, whereas weakly with LAM in TBHIV co-infection. PDL1
levels strongly correlated with plasma TNFα, IL6, IP10 and IL10 level in
TB subjects, and TNFα and IP10 in HIV patients. However, cytokine mRNA
from purified monocytes showed no association with either plasma
cytokines or monocyte PDL1, implying that if cytokines modulate PDL1,
there are likely not originating from circulating monocytes themselves.
These results underscore the importance of further characterization of
multiple monocyte subsets and their phenotypic and functional
differences in different disease states.