bluuebunny/crossref_metadata_2025 huggingface dataset:
The Development of an Ergonomic-Based Roadmap for Improving Passenger Mobility Onboard Intercity Trains in Indonesia
Authors: Sihman Lukman Septaekwara , Hitchcock David , Harding Kimberley , Abdillah Abdul Azis
Published: February 2024

Today in Indonesia, intercity railway service has become an essential part of human mobility and can carry more than 298 million passengers in 2022. It is a reliable service since it can carry many passengers and is a form of time-efficient mode of transport. More and more people are using this service including disabled passengers. They are using the railway to travel between the cities. The railway industry has changed a lot in recent years. If we look at the 90s and before, traveling by train was almost entirely used by non-disabled people and very few of the passengers are people with disabilities. It has now changed while some disabled passengers used the rail, and it created some issues for the industry. This service for disabled passengers is a part of Equality, Diversity, and Inclusion (EDI) and the Author found a mismatch between what the disabled passenger wanted and what the industry responded to. This research will try to understand what is happening in the Indonesian railway industry, compare it with the same issue in another country like the United Kingdom (UK), and what or how to get the ideal design and service for intercity onboard service for disabled passengers. This research uses the triangulation ergonomic principle which consists of measurement, observation, and consultation to combine a literature study and interviews with representatives of 4 stakeholders in the Indonesian railway: 1) A regular user of disabled passenger; 2) Executive Director of one of the Indonesian disability passengers Organization; 3) Traffic coordinator of the Directorate General of Railway (DGR) in the Indonesian Ministry of Transport; 4) A Vice President of the Passenger Division from PT. Kereta Api Indonesia (Persero)/KAI, an intercity railway operator. This interview is then combined with the data from the literature study then analyzed with several methods like Quality Function Deployment (QFD) to get the ideal coach design, Communication-Persuasion Matrix theory to address the communication gap between the parties and make an ideal roadmap solution with phasing approach.
Samenwerken in multidisciplinaire studententeams
Authors: Van Woerden Roosmarijn
Published: February 2024

Docenten en onderwijsontwikkelaars in het hoger onderwijs incorporeren vaak multidisciplinair teamwerk in hun onderwijs om studenten voor te bereiden op het analyseren van complexe problemen in teamverband. De onderzoeksvraag die in dit artikel centraal staat, is: hoe kan een research-informed raamwerk van samenwerken bijdragen aan het vormgeven van onderwijs waarin studenten samenwerken en leren in multidisciplinaire studententeams? Eerst wordt een raamwerk van aspecten van samenwerking gepresenteerd gebaseerd op een systematic review van de literatuur over teamwerk. Dit raamwerk omvat externe invloeden op het team, teaminput, teamproces en teamoutput en subcategorieën daarvan. In de specifieke context van multidisciplinaire studententeams zijn bepaalde aspecten van samenwerking uit het raamwerk extra relevant, zoals de rol van de docent, complexiteit en onzekerheid van de taak, taak- en uitkomstafhankelijkheid, gebrek aan tijd voor teamontwikkeling, teamcompositie, het managen van diversiteit van disciplinaire achtergronden, integratie van inzichten en leiderschapsstructuren.  Voor de ontwikkeling en uitvoering van onderwijs waarin studenten leren samen te werken in multidisciplinaire teams, zijn voor de relevante aspecten van samenwerking reflectievragen geformuleerd om te dienen als reflectietool voor docenten en onderwijsontwikkelaars.
Reflectie binnen technische hbo-opleidingen: ervaringen en behoeften van studenten en docenten
Authors: Mittendorff Kariene , Pullen Annedien
Published: February 2024

Het opleiden van reflectieve professionals wordt in de hedendaagse maatschappij steeds belangrijker. Opleidingen in het hoger onderwijs worden dan ook uitgedaagd om reflectievaardigheden van studenten een plek te geven in hun curriculum. Tegelijkertijd zien we dat docenten het moeilijk vinden om reflectieactiviteiten inhoudelijk goed vorm te geven en te begeleiden. Docenten van technische opleidingen vinden dit veelal nog lastiger, bijvoorbeeld vanwege de talige vorm waarin reflectie ook vaak vorm krijgt. Het thema lijkt niet altijd goed te passen bij hun doelgroep (studenten Techniek), maar ook niet bij hun eigen didactische repertoire. In dit artikel wordt verslag gedaan van een onderzoek naar de ervaringen (en behoeften) van studenten en docenten in vijf technische hbo-opleidingen (case study) als het gaat om de inzet van reflectie binnen hun opleiding. Hiervoor zijn docententeams en studenten van verschillende leerjaren geïnterviewd. De resultaten laten zien dat veel van de studenten en docenten vergelijkbare meningen of ervaringen hebben met betrekking tot de huidige en gewenste situatie. Vier belangrijke thema’s bieden aanknopingspunten om reflectie beter te integreren in de (technische) onderwijspraktijk: het ontwikkelen van een gezamenlijke visie op reflectie (in het team), het verbeteren van reflectieactiviteiten in het curriculum, het verbeteren van de begeleiding bij reflectie, en docentprofessionalisering.
Innovation Interconnected: Exploring The Frontiers Of Computing And Communication Technologies
Authors:   St. Xavier's Catholic College of Engineering, Tamil Nadu, India
Published: February 2024

This book covers a lot of ground, touching on topics like online intelligence, communication networks, business intelligence and knowledge management, and other areas that have an impact on IT growth. Databases, data mining, communications, embedded systems, web, internet of things, social network analysis, security, privacy, optical communication, and ubiquitous/pervasive computing are only a few of the many subjects covered by the many contributions. The book is useful for academics, students, and practitioners since many of the articles suggest interesting avenues for further study. Plus, it provides a great resource for anyone just entering the area as a reference.
A Study on The Antibiotic Use Pattern Among Patients with Urinary Tract Infections at a County Referral Hospital in Kenya
Authors:   BioRes Scientia LLC, D.K Kithuka , S.M Wainaina , D.J Opwoko
Published: February 2024

Urinary tract infections are a prevalent cause of hospital visits, particularly among females and the elderly. Timely diagnosis and adherence to clinical guidelines are crucial for effective management. This study aimed to evaluate antibiotic usage patterns in urinary tract infection patients at Thika Level 5 Hospital, providing insights into prescribing practices and guideline adherence. A cross-sectional study enrolled 308 participants using purposive sampling. Data were extracted from patient files and supplemented with information on clinical guideline availability and supplies for UTI diagnosis and treatment. Descriptive analysis was conducted using Microsoft Excel, with strict adherence to ethical data protection protocols. The study found that a significant proportion of participants (n=78, 25.4%) fell within the 39-49 years age group. Patients under 49 years old constituted the majority (n=200, 65.1%). Cystitis (41.4%) was the most common specific urinary tract infection diagnosis, followed by pyelonephritis (23.5%) and urethritis (18.9%). Common comorbidities included diabetes mellitus (n=31, 27.0%), benign prostatic hyperplasia (BPH) (n=16, 13.9%), and hydrocele (n=11, 9.6%). Ceftriaxone was the predominant antibiotic prescribed in both outpatient (single STAT doses) and inpatient settings, followed by cefixime (n=105, 34.2%) and azithromycin (n=70, 22.8%). Notably, most prescribed antibiotics belonged to the World Health Organization Watch list. Among the 307 prescriptions reviewed, only 112 (36.7%) adhered to Kenyan Clinical Management and Referral Guidelines Volume III. Non-compliant prescriptions involved incorrect antibiotic choice, inappropriate duration and lack of indication. However, prescription frequency, route of drug administration and total dose generally aligned with recommendations.
Paranoid Therapy Case Communication
Authors:   BioRes Scientia LLC, Jian Yufeng
Published: February 2024

We, the people, pray to ourselves. We know that your might is magnificent however those omnipotent might require growing and developing by ourselves. But you, the Deity, have better position to observe and listen to the voice of our souls. Such that we hope to report our understandings and voices to make you to have better judgement and then exert your powers.
Prevalence And Associated Factors of Anemia Among Reproductive Women in Eastern Ethiopia: A Cross-Sectional Study
Authors:   BioRes Scientia LLC, Gebrerufael Gebru Gebremeskel , Hagos Bsrat Tesfay
Published: February 2024

Background: Anemia for women in reproductive age continues to be a serious public health issue, especially in countries in Africa like Ethiopia. It is the most frequent reason for serious effects for both the mother and the fetus in women. There have been few investigations on the prevalence and determinants of anemia among reproductive women in the Somali regional state of Eastern Ethiopia. Because of this, the purpose of this study was to identify the prevalence and risk factors for anemia in the Somali regional state. Methods: From January 18 to June 27, 2016, a community-based cross-sectional investigation was carried out. STATA version 12 was used for the statistical analysis. We performed descriptive and summary statistics. To identify the significant factors connected to anemia, a multivariable binary logistic regression analysis was carried out after verifying for assumptions. In the multivariable model, risk factors for anemia were identified as adjusted odds ratios (AOR) with a 95% confidence interval (CI) and p-value < 0.05. Results: In this study, the overall prevalence of anemia among reproductive women residing in the Somali regional state was 58.4% (95% CI (0.557–0.611)). Around 8.7%, 40.03% and 51.29% of which anemic level reproductive women (15-49 years) were with severe (hemoglobin level: < 7.0 g per dl), moderate (hemoglobin level: 7.0–9.9 g per dl) and mild (hemoglobin level: 10–10.9 g per dl) type respectively. The multivariable binary logistic analysis revealed, predictors of rural residence (AOR =1.4; 95% CI: (1.08–1.93)), giving birth at older age of maternal 20–29 (AOR = 1.7; 95% CI: (1.19–2.54)), 30–39 (AOR =1.9; 95% CI: (1.27–2.76)), and 40–49 (AOR =1.8; 95% CI: (1.08–2.97)) years, being having antenatal care (ANC) follow-up (AOR = 0.44; 95% CI: (0.224–0.868)), and home place of delivery (AOR =1.5; 95% CI: (1.04–2.21)) were statistically predictors associated with anemia. Conclusions: In general, it is still discovered that the prevalence of anemia among reproductive women in the research area is extremely high (far above the national average). Rural residence, home place of delivery, ANC follow-up, and giving birth at older age of maternal were investigated as significant associated predictors of anemia among the study participants. Therefore, filling in the gaps that were discovered should lessen the anemia that is now an issue for women in this study who are of reproductive age.
Evaluation of Lipid Transfer Protein (Ltp) 1 Gene in Sesame and Other Plants Using Bioinformatics Approach
Authors:   BioRes Scientia LLC, Udensi O.U Edu N.E , F.N Agada , G.M Ubi , R Agbor
Published: February 2024

This study was aimed at using bioinformatics tools to characterize the Lipid Transfer Protein 1 gene in some selected accessions with special reference to Benny seed (Sesamum indicum) Lipid Transfer Protein 1 sequence as a query sequence. Nucleotide and amino acid sequences of 30 accessions were retrieved from NCBI database and analyzed for homology, physicochemical properties, motifs, GC content as well as phylogenetic relationships. Results showed that nucleotide and amino acid sequence lengths of this gene among the selected accessions differs. Its nucleotide length varied between 599–8461bp, while the amino acids sequence varied between 96–355 residues, Molecular weight range from 10008.77-35532.61daltons. With Sesamum indicum having the lowest molecular weight and Physcomitrium patens having the highest molecular weight. Result on the Theoretical PI was above 4.61 for all the amino acid sequences of Lipid Transfer Protein 1 gene in the selected accessions. It was observed that the total number of negatively charged residues ranged from 1-20. The instability index and aliphatic index ranged from 20.23–69.39, 73.48–102.24 respectively. Some of the proteins are stable, while twelve were considered unstable following the results for instability index. Extinction coefficient was highest for Sesamum indicum (14480). Daucus carota subsp. Sativus (-0213) is the only accessions with a negative GRAVY. The motifs N-glycosylation site, Plant lipid transfer proteins signature, N-myristoylation site, Casein kinase II phosphorylation site, Protein kinase C phosphorylation site were the most common across the selected accessions. GC content analysis revealed that it ranged from ranged from 29.73–54.55%. Analysis of the secondary structure of the amino acid sequences of the Lipid Transfer Protein 1 gene showed that the region covered by random coil was the highest in the sequences compared to alpha helix and extended strand. Alpha helix ranges from 33.11-54.31%, the extended strands ranged from 9.17–15.13%, while the random coil ranges from 32.77–51.16% across the accessions. Following the results of the present study, it can be concluded that Lipid Transfer Protein 1 gene sequence of Sesamum indicum is closely related to Lipid Transfer Protein 1 gene in Brachypodium distachyon and distant to that in Glycine max, Vigna unguiculata, Capsicum annum.
The Effects of Disability Grant Termination on The Livelihoods of Rural Women Aged Between 25-30 Living With HIV. A Case of Wellness Clinic at Vhembe District in Limpopo
Authors:   BioRes Scientia LLC, Mhangwani Chrisen E , Malindini Kholiswa
Published: February 2024

Introduction: The termination of the disability grant is identified as one of the determinants contributing to non-adherence to Anti-Retroviral Treatment (ART) by rural women living with HIV aged between 25-30 attending a Wellness Clinic in Vhembe District. The study has established that once the disability grant is terminated upon improved health outcomes as a result from adhering adequately to ART, the livelihoods of rural women living with HIV are adversely interrupted. Research purpose: The paper sought to explore and examine the effects of disability grant termination on the livelihoods of rural women living with HIV aged between 25-30 attending a Wellness Clinic in Vhembe District Research Approach: The paper adopted a qualitative approach and individual in-depth semi-structured interviews as a data collection technique. A purposive sampling technique was utilised to draw a sample of 20 rural women living with HIV attending a Wellness Clinic in Vhembe District who were enrolled on ART and whose disability grant was terminated upon improved health outcomes. The purpose was to elicit the participants’ views on their experiences on how the termination of the disability grant interferes with their livelihoods towards adhering effectively to ART. Main findings: The findings revealed that the termination of the disability grant for rural women living with HIV has adverse implications on their livelihoods towards adhering effectively to ART as access to the disability plays an important role to incentivise the adequate uptake of ART. Policy implications: Economic incentives for rural women living with HIV with little or no education has proven to contribute to optimal adherence to ART. However, the manner in which these economic incentives are provided for is a cause for concern in areas where poverty trends are prevalent. Therefore, policy makers should consider different modalities of access to the disability grant.
Adaptation of the Healthcare Team as The Key to TAVI Implantation
Authors:   BioRes Scientia LLC, Medina Susana Bailo , Alfageme Consuelo Arroyo , Toral Lorena Chueca , Piquero Virginia Abadía
Published: February 2024

We present the case of a 79-year-old female patient with a history of ischemic heart disease revascularized with stents and severe aortic stenosis, recently included in the surgical waiting list for treatment. She consulted for syncope and humerus fracture, preceded by chest pain with electrocardiographic changes. During the sequence of diagnostic tests indicated in this context, she suffered a severe clinical worsening, complicating to the point of acute pulmonary edema, cardiogenic shock and requiring mechanical ventilation. The underlying cause was severe aortic stenosis and, therefore, the ideal treatment was urgent percutaneous aortic valve implantation, since he had a peak peak gradient of 64 mmHg. The resolution of the case was not easy, since it required the transfer of a hemodynamically unstable patient from her hospital to the center specialized in TAVI implantation, located only 2 km away. What was new and exceptional was the adaptation of the usual treatment strategy (transfer of the patient to the referral center and scheduled implant) to a patient-centered strategy, which required the transfer of the TAVI expert team (nurses and physicians) together with the implant kit to the hospital where the patient was admitted.
Niemann-pick Disease: A Diagnostic Approach, Evolution Clinic and Review
Authors:   BioRes Scientia LLC, Valadares Flávia de Almeida , Alves Koch Eliza Noêmia , Silva Murilo Pires Ferreira da , Silvino Vasconcelos Pablo Vinícius , toast boiler Bruna Luiza , Da Fonseca Camila Marcelino , Santos Claudio Silva , Almeida Rodrigues Thaís Fernandes Theophilo de , Luz Gabriela Alves , Borelli Andressa Mendes , Zeuri Eduarda , Souza Brandao Sebastiana Julia , Soares Lara Oliveira
Published: February 2024

Introduction: Niemann-Pick disease is a rare autosomal recessive enzymopathy, which causes a deficiency in the activity of the acid sphingomyelinase enzyme found in liposomal cells, resulting in a defect in the degradation of sphingomyelin into ceramide - the product that makes up the lipid bilayer of the cells. In this way, it generates accumulation and deposition of sphingomyelin mainly in the liver, spleen, brain, bone marrow and lungs, which can cause hepatosplenomegaly, pulmonary/neurological diseases and cytopenia. Case presentation: Male patient, 16 years old, seeks care at a health center, accompanied by his mother, due to the drop in school performance in the last year. According to school assessment, the patient presents gradual cognitive impairment, in addition to dysarthria. Discussion: The disease in this report is rare and can occur in both sexes, with incidence and clinical presentation varying according to each subtype of the pathology. Due to its multisystem involvement, its clinical presentation can be nonspecific and make its diagnosis difficult. Conclusion: It should be noted that this work aims to spread knowledge about this rare pathology, showing the importance of recognizing it in childhood so that the diagnosis can be made as early as possible, bringing better survival for those affected.
Knowledge, Attitude and Practice and Associated Factors on Oxygen Therapy Among Nurses and Midwives in Y12 HMC-2022 Gc
Authors:   BioRes Scientia LLC, Kassaw Aragaw Birhane , Berhe Helen Assefa , Tarekegn Tewodros Kassahun , Bitew Seblewongel Esubalew , Hailu Kirubel Tesfaye , Hassen Buure Ayderuss , Betemariam Michael Yefrashowa , Abriha Feven Negasi , Mulu Aberha Hamlet , Lebelo Rediet Habtu , Dagnachew Solomon Endale , Teshome Efrata Sentayehu , Habtezgi Birukti Gebreyohannes , Tsegaye Surafel Alemayehu
Published: February 2024

Background: Oxygen is an essential medical therapy which saves a lot of lives. It is administered as a corrective treatment for conditions resulting in hypoxia (low level of oxygen in the blood). So, the nurse should have more skills and experience to performing this procedure in the aim to maintain the patient's life safe and avoid complications associated with incorrect oxygen administration technique. Objective: The study was conducted to assess the level of knowledge, attitude and practice towards oxygen therapy administration and associated factors among nurses and midwives at Yekatit 12 Hospital Medical college in 2022. Method: To achieve the research objectives a hospital based cross-sectional study was applied. The sample size drawn was 198. Pertinent data for the study were gathered through structured questionnaires. Descriptive and multiple logistic regression were used in the analysis of independent and outcome variables. Result: Data is collected from 211 participants and my response rate is (198)93.8%. Among 198 nurse and midwives 50.5% were males, 49.5% with the range of 30-39yrs and most of them (48.5%) have work experience of 6-9yrs.The mean score of knowledge, attitude and practice were 5.7(SD=1.608),4.01(SD=1.837) and 14.5(3.49) respectively. It is found that the level of knowledge was adequate in 117(59.1%) and poor 81 (40.9%) of participants. Practical skill is found to poor in 63.1% of participants and factors associated with this were absences of oxygen therapy guide line, not participating in any training about oxygen therapy and supply of oxygen delivery system with P-value of 0.01, 0.02 and 0.002 respectively. work experience also contributes for poor practice. Conclusion: There is a clear practical gap among nurses and midwives working in Y12HMC and this study also shows as there is poor attitude in almost have of the participants which high compared to another research. The possible associated factors for poor practice were identified as work experience less than 1yr and absence of training and oxygen guideline. So, to enhance safe use of oxygen therapy the referral hospital needs to push its effort for improving the practice and attitude of nurses and midwives towards oxygen therapy by facilitating trainings, increases the availability of guideline and supply of oxygen.
Prevalence of Gonorrhea and Associated Knowledge, Attitudes, and Practices among High School Students in Burao City, Somaliland
Authors:   BioRes Scientia LLC, Yosef Dek Kahin , Ali Adem Abdiaziz
Published: February 2024

Background: Gonorrhea, caused by the bacterium Neisseria gonorrhea, is a prevalent sexually transmitted infection (STI) that significantly impacts the health and well-being of individuals worldwide. It is the second most common preventable and treatable STI. In women, gonococcal infections often do not exhibit noticeable symptoms, leading to undetected and untreated infections. This can result in severe complications such as pelvic inflammatory disease, ectopic pregnancy, and infertility. Hence, the objective of this research was to evaluate the prevalence of gonorrhea infection among high school students in Burao city, Somaliland, while also examining their knowledge, attitudes, and practices associated with this infection. Methods: A quantitative method was employed to conduct an institutional-based cross-sectional study in selected schools in Burao city. The sampling method used was systematically random. To collect the data, a structured questionnaire with four parts was utilized. The collected data underwent a thorough process of checking for completeness, cleaning, coding, and entry using Kobo toolbox software (ODK). Subsequently, the data were exported to the Statistical Package for Social Sciences (SPSS) version 27 for analysis. Descriptive statistics were utilized to describe the study population to relevant variables. Furthermore, the chi-square test and odds ratio were performed at a 95% confidence interval using a p value of less than 0.05. Results: The study included 384 participants, with almost equal sex distributions. The response rate was high at 99%. The majority of participants had a negative attitude toward gonorrhea, while a significant proportion had accepted practices. The prevalence of gonorrhea was 2.1%. Logistic regression analysis revealed that good knowledge and a positive attitude toward gonorrhea were associated with higher levels of acceptable sexual practices. Additionally, practices and attitudes toward gonorrhea were strongly associated with each other. Conclusion: According to this study, the level of awareness regarding gonorrhea infection among schoolchildren in Burao city was significantly inadequate. Even though more than half of the students reported no sexual relationships, a considerable number of them were still engaging in risky sexual behaviors such as unprotected sex.
Knowledge, Attitude, and Practice of Mothers in Reproductive Age Group About Childhood Immunization in Basra, Iraq
Authors:   BioRes Scientia LLC, Naeem Hanna Naser , Ahmed Abdulqader Basra Rasha
Published: February 2024

Background: Childhood immunization preserves children from a variety of dangerous or potentially fatal diseases. World health organization (WHO) study has shown that 2.5 million deaths occurred yearly due to vaccine-preventable diseases, mainly in Asia and Africa among children under 5 years old. Vaccines nowadays protect against many diseases such as whooping cough, measles, and polio, which were the main causes of death for many children before them despite the same germs. In order to protect children from dangerous diseases as well as keep the community from outside diseases by decreasing the spread of diseases, immunization is a simple and effective way to do so. Aims: To assess the mother's knowledge, attitude, and practice concerning childhood vaccination. Methodology: This was a cross-sectional study done in three PHCCs (primary health care centers) from the first sector in the center of Basrah city, for the period from 24th of April to 1st of September 2019 on 414 mothers who visit the PHCCs for vaccination of their children and having at least one child aged less than five years. The data were collected by the researcher by using face to face interview method. Result: The results showed that (52.2%) of participants aged between 20 to less than 30, most of them were housewives and more than half of participants have 2-4 children. The majority of the mothers had good knowledge about childhood immunization apart from knowing of immunization schedule, more than half of the participants (60.4%) received their knowledge about vaccines from doctors and nursing staff in PHCCs and (77.3%) believed that the BCG (Bacillus Calmette-Guerin), hepatitis B or polio vaccines were the vaccines which should be given during the first week after delivery, nearly all of them (99.2%) agreed that the vaccines prevent diseases. Regarding the attitude and practice of the mothers (99.8%) recommend vaccines to every child, all of the mothers thought that compliance with the immunization schedule is important, and (94.2%) encourage mothers to vaccinate their children from campaigns. Nearly all participants fully immunized their children. Conclusion: Mothers had poor knowledge about immunization schedules. Nearly all of the mothers (99.8%) recommend the vaccine to every child. All of the participants thought that adherence to and completion of the immunization schedule are important. The majority of participants encourage vaccination campaigns. Nearly all of the mothers vaccinate their children completely. Recommendations: Explain to the mothers the importance of vaccines for children under five years and their role in the protection of children from serious diseases. Learn the mothers about the vaccines which is used in the immunization schedule.
Brain Death-Do not Resuscitate-End-of-life Care: A Literature Review
Authors:   BioRes Scientia LLC, Tzenalis Anastasios , Vasdeki Maria
Published: February 2024

One of the most discussed topics in the field of Intensive Care Unit is brain death. In 1968, for the first time, the committee of Harvard University in the USA established the change in the concept of death and thus "brain death" was equated with the death of the person. The ethical considerations surrounding brain death end-of-life care are complex and require health professionals to navigate difficult decisions, such as withholding treatment, with compassion and expertise. Nurses, being closely involved in patient care, have a unique perspective and influence on the quality of end-of-life care. Improving the quality of end-of-life care is critical to ensuring patient-centered care and support for patients and their families during this difficult time.
The Different Biologically Active Forms of Alpha-Fetoprotein as Functional Biomarkers in Pregnancy, Disease and Cancer: A Review and Update
Authors:   BioRes Scientia LLC, Mizejewski Gerald J.
Published: February 2024

Human alpha-fetoprotein (HAFP) has been known to manifest in multiple structural forms as previously reported in the biomedical literature. Such structural forms of HAFP have included isoforms, epitopes, carbohydrate and pH heterogenetic forms, and structural variants. However, within the last decade, studies have reported variant forms of HAFP not necessarily of a structural nature as reported in the literature. These newer forms of HAFP are largely functional forms in contrast to structural variants. Such functional forms are a result of slightly denatured intermediates (molten globule forms), conformational variants, misfolded proteins, conformationally transformed HAFP molecules, non-secreted forms, and synthetic peptide segments/sequences derived from the HAFP polypeptide. These latter bioactive functional forms of HAFP have been discussed in the present report. Such recently described forms of the oncofetal protein are deemed of importance since they can be utilized as functional bioactive markers during pregnancy, perinatal, perineurium and juvenile stages, in addition to benign and/or malignant tumor growths in adults.
High-Grade Chondrosarcoma of Nasal Septum-A Rare Case Report and Review of Literature
Authors:   BioRes Scientia LLC, Khairwa Anju
Published: February 2024

Chondrosarcoma of the nasal septum is a rare malignancy. Since 1927 to date, 69 cases of chondrosarcoma of nasal septum have been reported. In addition to the 70th case, we reported here. Mostly chondrosarcoma is present on the ends of long bones and 5-10% in the head-neck region. In our case, 50 years old female presented a bilateral nasal obstruction, and a biopsy was sent for nasal mass. Histomorphology suggested high-grade chondrosarcoma, which is positive for S-100 immunohistochemistry. Early intervention through radiology and biopsy will manage the patient with chondrosarcoma.
School Intervention: An experience focused on Initial Education Teachers
Authors:   BioRes Scientia LLC, Ison Zintilini Mirta Susana , González Daniela Fernanda
Published: February 2024

This study describes a project for and research on the implementation of program to strengthen socio-cognitive and emotional abilities in initial-level education of children (PHSCE), focused on training teachers on its implementation in the classroom. This work had two objectives: first, to explore the grade of acceptance of teachers regarding the training process both before and during the pandemic; and, second, to analyse the teachers' perceptions of the socio-cognitive and emotional performance of their students after they implemented the PHSCE. The results indicate that, before the pandemic, the degree of acceptance of teachers on the PHSCE was 79.1%. However, during the pandemic period, this percentage increased to 96.9%. The greatest improvements in children were in attentional performance, working memory, and peer relationships. The foundation for these psycho-educational programs is that socio-cognitive and emotional skills can be enhanced in early educational settings by providing supportive educational contexts.
Learning to Cope with Trauma and Moving Forward
Authors:   BioRes Scientia LLC, Taute Connie
Published: February 2024

Stages to processing trauma are basically nonexistent. Clients who have been through trauma and are struggling with emotions, irrational thoughts/fears, etc. are the inspiration for developing the stages of validating feelings/emotions, combating irrational thoughts/fears, developing and implementing healthy coping skills and avoiding negative coping skills, regaining control and power, and being able to move forward. Too many who have experienced trauma turn to drugs (methamphetamine, cocaine, heroin) or alcohol to “numb” the pain and the memories. This paper is to assist in developing healthy techniques for processing and moving forward after a traumatic event.
Is There a Relationship between Psychological Status and Posture in Chronic Low Back Pain?
Authors:   BioRes Scientia LLC, Khezami Mehrzia Amani , Bahlouli Emna , Ben Jeddou Imededdine , Ben Salah Fatma Zohra , Soltani Mouna , Aloulou Ines , Ghidaoui Leïla , Miri Imen , Lebib Sonia , Dziri Catherine
Published: February 2024

Context: Chronic non-specific low back pain (CNLBP) is a major public health. Numerous studies have evaluated the contribution of post urology in the assessment and the rehabilitation of this pathology. Nevertheless, the relationship between post urology and muscle assessment is still a subject of controversy and no clear cause and effect relationship between the two could be established. Aim: The aim of our work was to investigate the relationship between post urological and muscular assessments in patients with CNLBP. Methods: It’s about an observational, descriptive, and cross-sectional study. The muscle assessment included Quadriceps Femoris flexibility using the heel-to-buttock distance and Hamstrings flexibility using the popliteal angle. Isometric muscle strength of the extensor and flexor muscles of the trunk was assessed by the Biering-Sorensen test and the Shirado test, respectively. The evaluation of static postural control was performed by the SATEL® force platform in two conditions (opened eyes/closed mouth) and (closed eyes/closed mouth). The selected parameters were S (mm2), XY (mm), X (mm), Y (mm), support (%), and Romberg Quotient (RQ). The chi-square test or Fisher's exact test was used to assess differences between categorical variables, and means were compared using Pearson's or Spearman's correlation tests depending on the distribution of the variables. Comparison between qualitative and quantitative variables was done by ANOVA test for normally distributed variables and Mann-Whitney or Kruskall-Wallis tests for non-normally distributed data. Results: Forty patients were included. The study of muscle flexibility according to force platform parameters showed that left Hamstring stiffness was significantly correlated with XY (p=.037) and with instability in the sagittal plane (p=.036). On the other hand, the stiffness of the anterior rectus muscles (right and/or left) was significantly correlated with XY (p=0.019 for the right muscle and 0.011 for the left muscle) and with postural instability in the frontal plane (p=.015 for the right muscle and .026 for the left muscle). We also founded a significant association between the increase in Romberg quotient and right Hamstring stiffness (p=.003). Conclusions: Our study as well as literature findings suggest that the Quadriceps Femoris and the Hamstrings play have a significant role in core stability of patients with chronic non-specific back pain. However, the origin of the population is also an important factor in the postural evaluation. A larger number of patients and a control group would have made it possible to establish a cause- effect relationship between Quadriceps Femoris, Hamstrings and static postural control abnormalities.
The Disappearing Body in Anorexia Nervosa: Observation, Dissension, and Jouissance
Authors:   BioRes Scientia LLC, Makwana Gautam
Published: February 2024

Background: Anorexia nervosa is a prevalent psychopathological illness characterized by anorexia nervosa, where individuals reject the affective-pulsional aspect of the body and focus on its physiological aspects, denying the body's dimension, similar to Ponty's distinction between corpse propre and corps objective. The anorexic subject's body as a dead, desireless entity, rejecting food and language, creating a spiral of pure jouissance, isolating them from the outside world. Aim: The study aims to explore the mind-body connection and the potential for deterioration into psychopathological relationships between the subject and their body. Conclusion: The study explores the opposition between the physical body and the lived body in anorexia, focusing on the weave of past, present, and future, which is rejected by the anorexic subject, leading to death.
Hybrid Mode Psycho-Education and Supportive Psychotherapy for Depressive Symptoms: Observation Report
Authors:   BioRes Scientia LLC, Kumari Swati , N. K Mishra
Published: February 2024

Short-term approaches therapy for depressed adults, the patient was assigned to a short-term therapeutic approach. During covid -19, we all faced the lockdown; during this duration, everyone closed their homes; at the same time, online work mode came to intend, and teletherapy and Tele counseling also became popular in this period. This study was planned to see the efficacy of the hybrid mode of therapy. The patient was introduced to psycho-education, supportive therapy, relaxation, and behavioral activation (Activity Scheduling, Breathing Exercises, and JPMR) as a therapeutic intervention. The treatment outcome was based on self-reported and semi-structured clinical interviews for depressive episodes and current episodes of mild depression. After treatment, patients with the therapeutic approaches showed significant symptomatic improvement at the approaches level and clinical significance at the individual level.
Recurrent Ceot of Maxilla- A Case Report
Authors:   BioRes Scientia LLC, Kumar Prasanna , CH Mahableshwara , Lal Sahya S , Palekar Madhuri G
Published: February 2024

CEOT is a rare benign, locally aggressive odontogenic neoplasm, that affects the jaw. This slow-growing neoplasm occurring as intraosseous (94%) and extraosseous (6%) variants and with a frequency of 1-2%. The presentation of both intraosseous and extraosseous types is similar and both have similar histological features. Intraosseous CEOT is more aggressive, with a reported recurrence rate of 14%. The intraosseous CEOT shows a maxilla: mandible site ratio of 1:2 and are mainly located in the premolar/molar region. Even though, maxillary neoplasms should be treated more aggressively because of their close proximity to vital structures than mandibular lesions. Treatment modalities varies depends on the tumour size, location and histology. This case report emphasizing the importance of treatment modalities for a rare recurrent case of CEOT of maxilla.
Potential Use of Propolis as Endodontic Irrigant
Authors:   BioRes Scientia LLC, Carvalho Claudemir De , De Lima Elizandra Mara , Santos Moraes Ana Paula Dos , Da Silva Pereira
Published: February 2024

Objective of this work was to review the use of propolis as an endodontic irrigant. For this, keywords were searched in the PubMed database, from April to October 2022. There are many chemical compounds in propolis from different geographic regions; Flavonoids are one of the most important agents that have anti-inflammatory, anti-viral, anti-allergic, anti-cancer, anti-bacterial and antioxidant effects. According to the mentioned properties, propolis can be used as a canal irrigation solution, as well as intracanal medicine in endodontic treatments. The results described in the literature are practically unanimous in showing the antibacterial and antifungal effects of different propolis extracts at different concentrations. In addition to flavonoids, other components of propolis such as resin, pollen, vitamins and phenols, indicate that propolis can be used not only as an intracanal irrigation solution, but for various purposes, with a promising role in endodontics as well as dentistry.
More Orally Transmitted Aphorisms (OTA’s-2) in Dentistry
Authors:   BioRes Scientia LLC, Touyz Louis Z.G.
Published: February 2024

Background: Dentistry training is based on biomedical sciences. Previous clinical experience has produced principles that influence the practice of dentistry. Some of these oral advisories have been recorded. Aim: This article reports some more important orally transferred aphorisms (OTAs: Tapping-tooth-pain, Vertical Movement, Biopsies, Recognition, Ruboffable, ODD principle, and Show-up plaque), Assumption, and deconstructs their implications, reasons and significance. Discussion: These reported OTAs evolve from clinical expertise and each act as a guiding policy in the execution of dentistry. Conclusion: OTA’s have been inherited from succedaneous progressive generations of dentists; those reported here may be supplemented in future as long as dentistry evolves as a profession to produce more accumulating wisdom among dental health care workers.
The Effectiveness of Educational Mobile Messages on Prevention of Dental Caries in Group of Preschool Children
Authors:   BioRes Scientia LLC, Elsakkar Walaa F. , Mostafa Mohammed H. , Hashem Sara N.
Published: February 2024

Purpose: To estimate the impact of providing mobile educational messages on prevention of dental caries in group of preschool children. Materials and methods: 100 high caries risk children aged between 3 and 5 years from both genders were randomly allocated into two groups (n=50) regarding to receiving educational messages: test group; included children whose parents received educational messages and control group; included children whose parents didn’t receive any messages. Every 14 days the test group received educational messages via Whats Application Messenger (WhatsApp). Visible plaque index (VPI), the decayed, missed, filled (dmf) and the International Caries Detection and Assessment System (ICDAS) indices were measured at the start of the study, 3-, 6- and 9-month follow-ups, whereas Health Literacy levels and dietary habits were determined by HEALS literacy questionnaire at the start of the study and 9-month follow-up. Results: Educational messages increased parental HEALS scores, enhancing children’s oral health and reducing the severity of dental caries. Conclusion: Mobile educational messages provided through WhatsApp were efficient in reducing dental caries among preschool children and enhancing health literacy of the parents.
Ossified Inflammatory Epulis: A Case Report
Authors:   BioRes Scientia LLC, Moalla Hassen , Hachicha Ines , ketata Salma , Zouche Imene
Published: February 2024

Introduction: Etymologically, the epulis is a lesion that develops at the level of the gum. It is classically defined as a benign circumscribed hyperplastic pseudotumor of the gums. Observation: A 59-year-old patient consulted for a posterior left mandibular gingival mass related to 37 and 38 dilapidated. The lesion being well limited, of firm consistency and slow evolution without underlying osteolysis, evoked a fibrous epulis. The treatment consisted of eliminating the local irritant (RSD, extraction of the dental roots) and the complete excision of the lesion. Histological examination reveals the diagnosis of ossified inflammatory epulis. Discussion: Epulis is a common pseudotumor of the oral mucosa. Several varieties of epulis are described. Ossifying epulis is a controversial entity from a terminology point of view but it has the particularity of having bone and sometimes cemental metaplasia within the connective stroma which can sometimes be detectable on radiography. The success of the treatment remains dependent on the technique used by the practitioner, the follow-up, and the patient's degree of motivation for oral hygiene. The role of the first-line dentist remains important in the diagnosis, prevention, and treatment of this type of lesion as well as in the clinical follow-up.
State of Oral Health of Women in Rural Areas in an Underdeveloped Country: A Prospective Observational Descriptive Study
Authors:   BioRes Scientia LLC, Moalla Hassen , Karray Marwa , Ketata Salma , Zouche Imene
Published: February 2024

Introduction: Oral health is important in rural areas. It is necessary to have the good health of the women who have an axial role in the Tunisian rural economy. The objective of this study was to describe the state of oral health of women in rural areas. Materials and methods: We conducted a prospective observational descriptive study carried out at the delegation of Graïba in Sfax Tunisia within the framework of the medical caravan of the pink train. The form proposed by the World Health Organization for adults was used. Results: We included 121 women. The general sample's characteristics have been described. The prevalence of caries was 37.1%. The DMFT index is 2.5. Consumption of sweets concerned 9.1% of patients. Women had a bad brushing method at 77.7%. Periodontal inflammation affected 91.7% of women (111 patients). Conclusion: The state of oral health of women from rural areas in Tunisia was bad and it is necessary to act to improve it and raise awareness in rural areas by more supervision.
Intentional Replantation to Seal Apical and Lateral Canals in A Failed Endodontically Treated Tooth: A Case Report
Authors:   BioRes Scientia LLC, Asgary Saeed
Published: February 2024

Intentional replantation (IR) is often viewed as a last-resort intervention for failed endodontically treated teeth. This case report presents the successful management of symptomatic apical and lateral lesions through IR, highlighting its potential as an effective solution for challenging endodontic cases. A 45-year-old female patient presented with persistent pain and recurrent labial swelling in the vicinity of her left anterior tooth. Cone-beam computed tomography revealed endodontic lesions at both the apical and mesial aspects of tooth #21, leading to a diagnosis of symptomatic apical periodontitis. The IR procedure involved meticulous preparation and sealing of both apical and lateral canals with calcium-enriched mixture cement. One-year post-treatment, the patient remained asymptomatic, with clinical and radiographic assessments demonstrating a favorable prognosis and evidence of bone healing. This case demonstrates the successful management of symptomatic apical and lateral lesions through IR, offering an effective solution for challenging endodontic cases.