bluuebunny/crossref_metadata_2025 huggingface dataset:
Un modelo univariante para la predicción de crisis empresariales en un contexto macroeconómico turbulento
Authors: Terreno Dante Domingo , Pérez Jorge Orlando
Published: November 2022

Este estudio tiene por objetivo evaluar la utilidad de la relación entre flujos futuros de efectivo con el pasivo, identificado como ratio de capacidad de pago de las deudas, para el pronóstico de la crisis financiera. El análisis es efectuado en empresas del mercado de capitales de Argentina que enfrentan un contexto de fuertes desequilibrios macroeconómicos. Las conclusiones a las que se arriba indican que la capacidad de pago medida por los resultados operativos muestra una mayor precisión que la capacidad de pago por el EBITDA, resultados netos, flujos de efectivo operativos y el Z-score de Altman (1968). Por otro lado, las empresas con un mayor nivel de endeudamiento y una menor rentabilidad tienen una mayor probabilidad de entrar en crisis financiera. Además, se encuentra que la principal causa de la crisis financiera es la caída de los resultados operativos.
Gestión del riesgo climático mediante derivados. Aplicación al sector de líneas aéreas en México y España
Authors: López Domínguez Ignacio , Velázquez Boeta Rebeca
Published: November 2022

El propósito de esta investigación es analizar la utilización de derivados climáticos como cobertura de dicha fuente de riesgo, tanto en el mercado español como en el mercado mexicano. Como objetivo, se busca minimizar el impacto negativo sobre las actividades económicas de las empresas de cada mercado ante el comportamiento del clima. Para ello, se identificó el riesgo climático de las empresas mexicanas y españolas del sector de líneas aéreas, se analizó la gestión del mismo riesgo mediante el empleo de derivados climáticos, y se finalizó con un estudio comparativo de la mejora de la gestión de las compañías respectivas tras la utilización de tales productos. La conclusión más relevante es que la implementación funciona mejor en el sector mexicano, ya que es más sensible al clima. En el caso de España, se percibe una mejora en la calidad de enfrentamiento de riesgos climáticos; sin embargo, es necesario mantener una administración de riesgo climático con el fin de minimizar la incertidumbre por el cambio climático.
Yield Response of Maize to Irrigation and Nitrogen Fertilization
Authors: Rimmi S.N. , Islam M.S. , Alam M.S. , Khan M.A.R. , Binte B.I.
Published: November 2022

Background: A field experiment was conducted during November, 2018 to April, 2019 to evaluate the response of maize to irrigation and nitrogenous fertilizer in shallow red brown terrace soil of Madhupur Tract under AEZ-28 in Bangladesh. Methods: The irrigation was provided as factor A at four distinct rates (irrigation at 20%, 40%, 60% and 80% available water) and nitrogenous fertilizer as factor B at three dosages (75%, 100% and 125% of recommended dose) when each factor was repeated three times. Data relevant to soil and plant parameters were analyzed for variance (ANOVA) using Statistix 10. Result: The yield and yield contributing characters of maize responded significantly to varying degrees of irrigation and N fertilizer, with the treatment I4N2 having the highest cob per plant (1.17), cob yield (16.89 t ha-1), grain yield (9.19 t ha-1), dry matter yield (10.15 t ha-1) and the treatment I3N3 provided statistically identical results as I4N2. The treatment I4N2 also resulted in maximum content of grain N (0.87%), P (0.20%) and K (0.26%). The treatment, irrigation at 80% available water with application of 100% N on recommended dose (I4N2) appeared as the most suitable package for maize cultivation in the stated region.
Detection of Biofilm Formation by Escherichia coli and Staphylococcus aureus Associated with Canine Pyometra
Authors: Amrutha M.S. , Sankar Surya , Mani Binu K. , Harshan Hiron M. , Vidya P. , Paulson Susmi T.
Published: November 2022

Background: Antibiotic resistance is one of the major problems encountered in the therapy of canine pyometra. The ability of bacteria to form biofilm is implicated as one of the factors responsible for this. Escherichia coli and Staphylococcus aureus are the predominant bacteria associated with pyometra in canines and are known for their biofilm formation. Keeping in this view, a preliminary study was conducted to detect the biofilm forming strains of E. coli and S. aureus, if any, associated with canine pyometra. Methods: A total of 25 samples were collected, which included uterine discharges from cases of closed pyometra and anterior vaginal swabs from open pyometra. The isolates of E. coli and S. aureus were identified based on the cultural, morphological and biochemical characteristics. These isolates were subjected to antibiotic sensitivity test employing disc diffusion method. For biofilm detection, the isolates were screened by Congo red agar method, tube method and tissue culture plate method. Result: From 25 samples, two Streptococcus spp., thirteen Staphylococcus spp., seven E.coli, five Klebsiella spp. and two Pseudomonas spp. were isolated. All the isolates were found to be multi-drug resistant on antibiogram. The tissue culture plate and Congo red agar method was found more sensitive to detect the biofilm formation by S. aureus and E.coli isolates, respectively. The biofilm forming strains showed higher degree of antibiotic resistance in comparison with non-formers, indicating it as one of the major reasons for failure of antibiotic therapy in canine pyometra.
Elucidation of Genetic Mechanism Governing Heterosis in Pigeonpea [Cajanus cajan (L.) Millspaugh]
Authors: Gaur Amit Kumar , Verma S.K. , Sharma R.K. , Bhardwaj Rajneesh , Bisht Charu , Deep Harsh , Yadav Harikant
Published: November 2022

Background: The findings of the present research will provide an indepth understanding of important parameters contributing to heterosis in pigeonpea. Methods: Combining ability effects and heterosis of crosses were determined among 45 hybrids developed by crossing 10 elite pigeonpea genotypes in half diallel fashion. The combining abilities were estimated by using Griffing’s, Method II and Model I. Result: The SCA followed by MGCA (mean general combinig ability of parents) were observed as the most reliable parameters to predict heterosis. High per se performance of parents and high genetic diversity does not lead to high heterosis. The parents having high x low per se performance, good x poor GCA effects and medium genetic diversity resulted in high frequency of heterotic hybrids. The results indicated that the hybrid Paras x PA 624 exhibited maximum mid parent, better parent and standard heterosis for seed yield.
Amélioration des Performances du Système de Traitement Tertiaire des Eaux de Rejet par Lagunage Naturel à la Station d’Épuration de Thiès (Sénégal)
Authors: Thiao Yaye Ndew , Faye Mamadou , Toure Alpha Ousmane , Dieng Modou , Sambe Falilou Mbacké
Published: November 2022

Ce présent article aborde la méthode utilisée pour corriger la non-conformité par rapport aux normes sénégalaises de rejet NS-05-061 des paramètres de pollution physico-chimiques des eaux en sortie de traitement de la station d’épuration des eaux usées de Keur Saïb Ndoye à Thiès. La station d’épuration de Keur Saïb Ndoye de Thiès, après onze (11) années de fonctionnement, est confrontée à une baisse de rendement d’épuration qui affecte les paramètres de pollution physiques et organiques en sortie de lagunage. Au début des expériences, pour l’année 2017, la station a obtenu des valeurs moyennes en sortie de 102 contre 50 mg/L pour les MES, 135 contre 40 mg/L pour la DBO5 et 180 contre 100mg/L pour la DCO. Pour observer à nouveau les normes sénégalaises de rejet, il a été préconisé l’isolement complet de l’une des deux séries de lagunes durant le second semestre de l’année 2018, afin de réduire le temps de séjour. Un suivi des paramètres de contrôle a été réalisé aux laboratoires de Thiès et de Cambérène sur la période de 2018 à la fin de l’année 2019 sur des échantillons prélevés à l’entrée de la STEP et en sortie de traitement tertiaire avant, pendant et après isolement de l’une des séries de lagunes. Les résultats de l’année 2019, après un an et demi de fonctionnement avec une seule série de quatre lagunes ont été satisfaisants dans leur globalité avec des rendements moyens annuels tous supérieurs à 90% pour les MES, la DBO5 et la DCO. Des concentrations en sortie en MES, DBO5 et DCO dans l’effluent rejeté, respectivement de l’ordre de 38 mg/L, 42,8 mg/L et 91,3mg/L sont obtenues. Ces valeurs sont nettement inférieures à l’exception près de la DBO5 aux seuils fixés par la Norme sénégalaise.
Internet as a Meeting Place for Spouses: Online Dating, Homogamy and Assortative Mating in Contemporary Italy
Authors: Arosio Laura
Published: November 2022

In this article places where spouses first met in Italy are studied. The focus is on online settings in the most recent marriage cohorts (2000-2016). The aim is to investigate trends over time of using the Internet as a meeting place and to explore whether Internet dating can affect assortative mating and homogamy rules. Information on first marriages is analysed to study highly committed and long-lasting relationships between partners. Data used for the analyses come from the nationally representative survey "Family, Social Subjects and Life Cycle" carried out by the Italian National Statistical Institute (Istat) in 2016 on a sample of about 32,000 individuals made available in 2020. The results allow a preliminary quantification of the phenomenon and document an increase in meetings occurring online in Italy (from 0.4 per cent in the marriage cohort 2000-2009 to 2.5 per cent in the marriage cohort 2010-2016). Furthermore, data support the idea that online contexts show homogamy paths not different from those that characterize offline dating venues. Meeting a partner online does not seem to imply heterogamy.
Maternal-Fetal Attachment Levels in The Prenatal Period and the Factors Affecting It
Authors: DAĞLI Elif , İNAL Sevil
Published: November 2022

Attachment, which begins in the prenatal period, is an important determinant for maternal and fetal/infant health. The mother, who is attached to her baby with love, contributes positively to the healthy growth and development of the baby. This study aimed to determine maternal-fetal attachment levels in the prenatal period and the factors affecting it. The study, which used a cross-sectional design, was conducted on women with pregnancy presenting to the obstetrics outpatient clinic of a state hospital. The study consisted of a total of 170 women with pregnancy who presented to the outpatient clinic for general control. The study data were collected face-to-face using a questionnaire and the Prenatal Attachment Inventory (PAI). The findings also indicated that the mean age of women with pregnancy was 27.26±5.62 (years), the mean current gestational week was 33.48±3.12 (week), and the mean PAI score was 65.54±10.40. A statistically significant relationship was determined between the mean PAI scores of the women with pregnancy and their income level, employment status, sex of baby, and getting the support of the spouse during pregnancy (P
History of Reading in Russia. New Knowledge
Authors: Moreva O. V.
Published: November 2022

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Software and Hardware Support of the Project “Library of a New Generation in Creative University” at the Kemerovo State Institute of Culture
Authors: Bobrova E. I.
Published: November 2022

The results of the project “Library of a new generation in creative university” within the framework of the federal project “Creative People”, carried out at the Kemerovo State Institute of Culture in the direction of “Library and information activities” in terms of software and hardware implementation, are presented. Goals and objectives of the project were the following: creation of a comfortable environment for students, organization of an accessible environment for servicing people with disabilities, implantation of RFID systems, digital technologies for the formation of digital competencies of students and improvement of the digital information environment of the institute. The software and hardware, the results of their operation are considered. The practical results of the project implementation are outlined: the introduction of new services on the library bases, promotional events, publications in professional editions, the inclusion of the elective “VR-design” in the curriculum, the formation of digital content (electronic library of music publications, 3D modeling), the transfer of the library fund to RFID technology. Project prospects are shown: experiments in the field of work with information support of science and education, the formation of an open information space, including the work with new types of data; enriching the educational experience of students by creating a rich educational environment in physical and virtual space.
Master’s Textbook on Book Studies: Basic Problems and Prospects of Training
Authors: Elyashevich D. A. , Mutyev V. A.
Published: November 2022

The results of the study of master’s programs in the field of training “library and information activities” are presented, their shortcomings in terms of the formation of book-related bibliological competencies are revealed. A new formulation of the object of book studies has been put forward, reflecting its modern essence “author – writing – text – reading – reader”, according to which the structure of the master’s textbook is proposed. The problems of historiography, scientific method and methodology of bibliological research are analyzed. The medialogical approach in the broad context of humanitarian discourse as the main one in the preparation of the textbook is considered.
Religious Books in the Reconstructed Fond in the Library of the Orenburg Theological Seminary
Authors: Bezpalova A. V.
Published: November 2022

The article is devoted to the library of the Orenburg Theological Seminary, which was lost in 1918. It was based on the books of spiritual and religious content. The purpose of the library reconstruction is to create its approximate catalog at the time of the seminary closure. The article describes only that sections of the catalog that reflect physically preserved books: Holy Scripture, Dogmatic Theology, Homiletics, Pastoral Theology, Moral Theology, Asceticism, Ecumenism, Christian apologetics, Schismatic studies, history of non-Christian religions, history of the Russian Orthodox Church, etc. Only 35 copies have been survived to this day. All of them are monuments of book culture and give an idea of both the representativeness of the lost library itself and the preparation of clergymen for missionary activity in the Orenburg Orthodox Diocese.
Allergy is an Immune Disorder Related to a Lack of Regulation: The Gluing Role of IL-2
Authors: Mengel Jose
Published: November 2022

This manuscript provides a new integrated view of the development of allergen-specific TH2 and the lack of their associated Treg cells in a unified model, justifying the need for IL-2 to correct allergy conditions.
Curcumin and Its Affection for Sleep Deprivation
Authors: Pandey Ramendra , Kumar Rohit , Chang Chung-Ming
Published: November 2022

In this review, the following information describes the manifestation of sleep deprivation by human beings and its adverse effect on their health. Sleep deprivation has been demonstrated into namely two types known as REM sleep and NREM sleep affecting our health in so a problematic way that it is making our body immune to many diseases leading to lethal problems. Therefore, great research by many scientists has discovered that the turmeric “Curcuma longa” which is been used in every Indian kitchen since ancient times, has shown a remarkable effect on the problem caused by sleep deprivation but due to its poor solubility and low bioavailability drawn it into a great disadvantage. But the help of the study of nanotechnology and the evolution of curcumin into nano–curcumin made the possibility of the remarkable effect by making the curcumin more potent and enhancing its stability. Immunological changes due to sleep deprivation lead to Alzheimer’s disease, glioma, neuropathic pains, and many more. Therefore, this review has been summarized as it is been providing information related to curcumin and its affection for sleep deprivation.
Evaluation of Some Defense Gene Expression in Soybean Cultivars under Drought Stress
Authors: Mazandarani Abolfazl , Kalaji Mohammad Hazem , Ghasemi Mosremi Ameneh , Abbasi Fereshteh
Published: November 2022

Drought stress on soybean is a research-demanding matter for negative influence that agricultural drought brings about. This study was designated to evaluate the effect of drought stress on some gene expression in flowering and pod elongation stages in soybean. This experiment was carried out in split-plot format with RCBD design with four replicates. Drought stress as the main factor included three levels (irrigation after 50, 100, and 150 millimeters evaporation from the A-class evaporation pot) of which 50 millimeters evaporation is considered as control. The sub-factor included a factorial combination of 3 varieties (DPX, Sari and WE6) and two sampling stages (flowering and pod elongation). The gene expression analysis was carried out by using the QRT-PCR technique. According to our results, all genes have shown overexpression in drought stress despite this result was not the same for all genotypes and stress levels. Some genes have up-regulated in mediate stress (treatment 100) level (like as Gmdreb 2, Gmdreb 5, GmRD20A, GmaxACD2) and other genes up-regulated in serve stress (treatment 150) level. Between genotypes, DPX cultivar and WE6 line were better than of the sari cultivar for all genes up-regulated.
Divulging a Pleiotropic Role of Succinate Receptor SUCNR1 in Renal Cell Carcinoma Microenvironment
Authors: Najm Rania , Al Mashhadani Mahmood , Kandasamy Richard
Published: November 2022

The succinate receptor, SUCNR1, has been attributed to tumor progression, metastasis, and im-mune response modulation upon its activation via the oncometabolite succinate. Nonetheless, lit-tle is known about SUCNR1 prognostic relevance and its association with tumor immune infil-trates and microbiota in renal cell carcinoma (RCC). Herein, publicly available platforms in-cluding Human Protein Atlas, cBioPortal, TIMER2, and TISIDB were utilized to depict a diver-gent implication of SUCNR1 in the immune microenvironment of clear cell RCC (KIRC) and pa-pillary RCC (KIRP); the two major subtypes of RCC. Our results showed that SUCNR1 expression level was augmented in RCC compared to other solid cancers, yet with opposite survival rate predictions in RCC subtypes. Consequently, higher expression level of SUCNR1 was associated with a good disease-specific survival rate (p=5.797e-5) in KIRC patients albeit a poor prognostic prediction in KIRP patients (p=1.9282e-3). Intriguingly, SUCNR1 was mainly correlated to im-munomodulators and diverse immune infiltrates in KIRP. Whereas the receptor was mostly asso-ciated with a repertoire of microbes including beneficial bacteria that likely influenced a better disease-specific survival rate in KIRC. Our findings illustrate a significant subtype-specific role of SUCNR1 in RCC which potentially modulates tumor immune infiltration and microbiome sig-nature, hence altering the prognosis of cancer patients.
Analysis of Fast Fluorescence Kinetics of a Single Cyanobacterium Trapped in an Optical Microcavity
Authors: Rammler Tim , Wackenhut Frank , Rapp Johanna , Zur Oven-Krockhaus Sven , Forchhammer Karl , Harter Klaus , Meixner Alfred J.
Published: November 2022

Photosynthesis is one the most important biological processes on earth, producing life-giving oxygen and is the basis for a large variety of plant products. Measurable properties of photosynthesis provide information about its biophysical state and, in turn, the physiological conditions of a photoautotrophic organism. For instance, chlorophyll fluorescence of an intact photosystem is not linear as in the case of a single fluorescent dye in solution, but shows temporal changes related to the quantum yield of the photosystem. Commercial photosystem analyzers already use the fluorescence kinetics characteristics of photosystems to infer the viability of organisms under investigation. Here, we provide a novel approach based on an optical Fabry-Pérot microcavity or that enables the readout of photosynthetic properties and activity for an individual cyanobacterium. This approach offers a completely new dimension of information, which would normally be lost due to averaging in ensemble measurements obtained from a large population of bacteria.
Cost-Effective PCR-Based Identification of Tunga penetrans (Siphonaptera) Larvae Extracted From Soil Samples Containing PCR Inhibitor-Rich Material
Authors: Amugune Billy L. , Matharu Abneel K. , Ouma Paul , Mutebi Francis , Elson Lynne , Fillinger Ulrike , Krücken Jürgen
Published: November 2022

Tungiasis is a neglected tropical disease caused by skin-penetrating female Tunga penetrans fleas. Although tungiasis causes severe health problems, its ecology is poorly understood and morphological descriptions of larvae are unavailable. To identify T. penetrans immature stages and sites where they develop, diagnostic PCRs are required. However, flea larvae feed on soil organic matter rich in PCR inhibitors. Here, three DNA preparation methods, a soil DNA kit removing inhibitors, a simple ammonium acetate precipitation approach (AmAcet) and a crude lysate of larvae (CL), were combined with amplification by the highly processive FIREPol® Taq or the inhibitor-resistant Phusion® polymerase. Independent of the polymerase used, frequency of successful amplification, Cq values and PCR efficacies for the low-cost CL and AmAcet methods were superior to the commercial kit for amplification of a 278 bp partial internal transcribed spacer-2 (ITS-2) and a 730 bp pan-Siphonaptera cytochrome oxidase I PCR. For the CL method combined with Phusion® polymerase, costs were approximately 20-fold lower than for methods based on the soil DNA kit, which is a considerable advantage in resource-poor settings. The ITS-2 PCR did not amplify Ctenocephalides felis genomic or Tunga trimammilata ITS-2 plasmid DNA allowing it to be used to specifically identify T. penetrans.
A Novel Algorithm for Histopathological Lung Cancer Detection
Authors: Faria Nelson Filipe Miranda , Campelos Sofia , Carvalho Vítor
Published: November 2022

Lung cancer is the leading cause of cancer mortality worldwide, and it is urgently necessary to diagnose it as early as possible. Usually, the diagnostic process begins with a radiological examination which, when a possible tumour is present, is followed by a biopsy to extract tissue samples from the patient's lungs. Therefore, the purpose of this study is the development of an artificial intelligence algorithm that will analyse the Whole Slide Image (WSI) generated by the digitisation of the glass slides obtained from the extracted samples and detect if there is a tumour. The developed learning algorithms as well as the tested neural networks (NNs) were trained on a dataset composed of previously annotated WSI tiles, classified as Tumour or Non-Tumour. From these, four developed convolutional neural networks stood out and were selected to be compared with each other and with the tested NNs. When the best result of each of the developed architectures was compared to the highest result of the tested NNs, it was possible to denote that version 4 of CancerDetecNN achieved an average accuracy of 89.749 \% and an average loss of 0.220. Furthermore, the results for the four selected versions are in agreement with the results reported in the literature, however, the limited size of the given dataset must be considered. Given the results obtained, the fourth version has the potential to optimise the lung cancer diagnosis process.
Analyzing Brand Awareness Strategies on Social Media in the Luxury Market: the Case of Italian Fashion
Authors: Brambilla Marco , Badrizadeh Hoda , Malek Mohammadi Narges , Javadian Sabet Alireza
Published: November 2022

The rapid penetration of social media has been redefining every facet of the old marketing and customer engagement tactics, not only for the low-end and mass products but also for luxury brands. In this context, brands are dealing with the challenge of keeping the balance between using mass marketing strategies concurrent with accentuating the exclusivity of their offerings. Social media can be considered a boon if brands employ them to reach the right audience and use the right platform by incorporating the right content. In this work, we propose a sector-specific, integrated, and holistic investigation of the social media strategies of luxury brands, together with the impact they generate in terms of the engagement level of the users as an indicator of their success. We provide empirical validation of the method in the sector of luxury fashion brands in the Italian market, providing qualitative and quantitative analysis of the content shared on social media, considering the type, timing, and modality of the sharing. We evaluate consumer-brand engagement in different contexts, including important live events in the field.
Review on Epidemiological Interface of Tuberculosis At Human Livestock Wildlife in Ethiopia
Authors: Mulatu Henok , Mohammed Shaban
Published: November 2022

Bovine tuberculosis (BTB) is endemic in Ethiopian cattle. BTB is caused by Mycobacterium bovis (M. bovis) and has economic and public health significance. which has significant impact on the health of livestock and human. It has been significantly a cause for great economic loss in animal production. Associated risk factors contributed to the prevalence of the disease in cattle and its transmission. Moreover, the majority of cattle owners lack awareness about the disease and its public health significance. The presence of multiple hosts including wild animals, inefficient diagnostic techniques, absence of defined national controls and eradication programs could impede the control of bovine TB. Awareness rising about the disease, its transmission andzoonotic implication however, in Ethiopia Bovine Tuberculosis in Human-Livestock-Wildlife Interface is not well studied in the country and there were no studies concerning the burden of the disease between human ,animal and wild life which is of great importance for reduction and control measures. This paper aims to review the potential health and economic impact of bovine tuberculosis control in order to safeguard human and animal population in Ethiopia
The Ultrasound Action on the Laser– Induced Breakdown and Spectral Elemental Analyzes of Seawater
Authors: Bulanov Alexey V. , Krikun Vladimir A. , Nagorny Ivan G.
Published: November 2022

This paper develops the study of the effect of powerful ultrasound on the laser breakdown of liquids and a comparative study of the possibilities of acoustic and optical diagnostics of breakdown. The method of laser-induced breakdown spectroscopy (LIBS) for elemental analysis of liquids, along with high efficiency, continues to be less sensitive compared to traditional chemical methods. The paper develops a method of using additional ultrasound irradiation of the laser breakdown area in order to increase the efficiency of LIBS. Using the developed technique, spectral lines of chemical elements such as potassium, manganese, sodium, calcium, etc. were obtained for the first time depending on the frequency and power of ultrasound. It is shown that a sharp increase in the intensity of spectral lines of elements in water during laser breakdown is observed in the field of high-power ultrasound. It indicates an increase in the sensitivity of the combined method of ultrasonic LIBS. Along with the optical spectrum, the spectral and energy characteristics of acoustic emission were studied. An automated complex for hydrophysical and spectral studies is described, which was tested in the Sea of Japan during the voyage No. 81 of the research vessel RV "Professor Gagarinsky" in August 2022.
Alterations in Kidney Structures Caused by Age Vary According to Sex and Dehydration Condition
Authors: Cognuck Susana Quirós , Almeida Lucas Ferreira de , Reis Wagner L. , Silva Márcia S. , Pereira Gislaine Almeida , Zorro Sandra V. , Mecawi André S. , Coimbra Terezila Machado , Elias Lucila L.K. , Antunes Rodrigues José Antunes
Published: November 2022

Aging is a complex biological process, with gradual and progressive decline in structure and function in many organ systems. Our objective is to determine if structural changes produced by aging, vary with sex, in a stressful situation such as dehydration. The expression of Slc12a3 mRNA in renal cortex, α-smooth muscle actin (α-SMA) and fibronectin, was evaluated in male and female rats aged 3 and 18 months submitted or not to water deprivation (WD) for 48 hours. When comparing ages, 18-month-old males showed lower expression of Slc12a3 mRNA than 3-month-old males, and control and WD 18-moth-old male and female rats exhibited higher expression of α-SMA than respective 3-month-old rats. Fibronectin was higher in both control and WD 18-month-old males than respective 3-month-old males. In females, only control 18-month-old rats showed higher fibronectin than control 3-month-old rats. When we compared sex, control and WD 3-month-old female rats had lower expression of Slc12a3 mRNA than re-spective males. WD 18-month-old male rats presented higher expression of fibronectin and α-SMA than WD 18-month-old female rats. When we compared hydric condition, WD 18-month-old males displayed lower relative expression of Slc12a3 mRNA and higher α-SMA expression than control 18-month-old males. Aging, sex, and dehydration lead to alteration in kidney structure.
A Study on the Bilateral Trade Relations between China and ASEAN Ten Countries Based on Lotka-Volterra Model
Authors: Ruan Wen-Xi , Yu Xin , Wang Sheng-Yuan , Zhao Tian-Cheng , Liu Ya-Zhen
Published: November 2022

The bilateral trade relationship between PRC and ASEAN is close. As early as 2012, China has been the largest trading partner of ASEAN, and ASEAN has also taken the place of the United States as PRC’s second largest trading partner in 2019.This paper uses the theory of ecological population evolution, selects the total import and export volume of PRC and the ten ASEAN countries from 2000 to 2019 as the data sample, studies the bilateral trade relations between PRC and the ten ASEAN countries, analyzes the competition and symbiotic relationship of bilateral trade between PRC and the ten ASEAN countries and the possibility of trade friction according to the results, and proposes corresponding improvement strategies. According to the results of the population evolution competition model, China has a competitive relationship with Indonesia, Malaysia, the Philippines, Singapore and Thailand, which is most likely to cause trade friction. China has a biased relationship with Brunei, Cambodia, Laos, Myanmar and Vietnam, which is more likely to cause trade friction. On this basis, in order to further strengthen the trade relations between PRC and the ten ASEAN countries, this paper puts forward policy suggestions on improving infrastructure, strengthening independent innovation, seeking cooperation fields and actively investing abroad.
Coordination of LMO7 with FAK Sustains Epithelial Integrity in Renal Epithelia Exposed to Osmotic Pressure
Authors: Zhen Yen-Yi , Wu Chien-Hsing , Chen Hung-Chun , Chang Eddy Essen , Lee Jia-Jung , Chang Jer-Ming , Chen Wei-Yu , Tseng Pei-Yun , Wang Yue-Fang , Hung Chi-Chih
Published: November 2022

In kidney, epithelial barrier has diverse functions in body fluid and electrolyte homeostasis, and urine production. Maintaining epithelial integrity fundamentally builds up physiological functionality of the renal epithelial barrier (REB). Specially, the REB) states regularly in osmotic dynamics. The osmotic dynamics gives rise of osmotic pressure that is a physical force. Overloading of osmotic pressure can crack epithelial integrity and damage REB. How REB endures the osmotic pressure force yet remains enigmatic. LMO7 (LIM domain only 7) is a protein associated with cell-cell junctional complex and cortical F-actin. LMO7 upregulation was observed in cells cultured in hypertonic condition. In kidney, LMO7 predominantly distributes in epithelial cells in renal tubules. Hypertonic stimulation leads to assembly of LMO7 and F-actin in cortical stress fibers in renal epithelial cells. Hypertonic-isotonic alternation as pressure force pushing plasma membrane inward/outward was set as osmotic disturbance and was applied to test FAK signaling and LMO7 functioning in maintaining junctional integrity. Along with junctional integrity, LMO7 depleted cells resulted in loss of junctional integrity in the epithelial sheet cultured hypertonic medium or hypertonic-isotonic alternation. On the other hand, FAK inhibited by PF-573228 leads to failure in robust cortical F-actin assembly and association of LMO7 with cortical F-actin in epithelial cells responding upon hypertonic stress. Epithelial integrity in context of osmotic stress, LMO7 and FAK signaling both involves in assembling robust cortical F-actin and maintaining junctional integrity. The LMO7 elaborately manages FAK activation in renal epithelial cells, which was evidently demonstrated in NRK-52E cells who have excessive FAK activation and lost epithelial integrity when cells with LMO7 depletion exposed to hypertonic environment. Our data suggests that LOM7 manages FAK activation and is responsible for maintaining REB under osmotic disturbance.
Genomic Diversity and Chromosomal Rearrangements in Neisseria Gonorrhoeae and Neisseria Meningitidis
Authors: Shaskolskiy Boris , Kravtsov Dmitry , Kandinov Ilya , Dementieva Ekaterina , Gryadunov Dmitry
Published: November 2022

Chromosomal rearrangements in N. gonorrhoeae and N. meningitidis were studied with the determination of mobile elements and their role in rearrangements. The results of whole-genome sequencing and de novo genome assembly for 50 N. gonorrhoeae isolates collected in Russia were compared with 96 genomes of N. gonorrhoeae and 138 genomes of N. meningitidis from the databases. Rearrangement events with the determination of the coordinates of syntenic blocks were analyzed using the SibeliaZ software, the minimum number of events that allow one genome to pass into another was calculated using the DCJ-indel model using the UniMoG program. Population-level analysis revealed a stronger correlation between changes in the gene order and phylogenetic proximity for N. meningitidis in contrast to N. gonorrhoeae. Mobile elements were identified, including Correa elements, Spencer-Smith elements (in N. gonorrhoeae), Neisserial intergenic mosaic elements, IS elements of IS5, IS30, IS110, IS1595 groups, Nf1-Nf3 prophages, NgoФ1-NgoФ9 prophages, Mu-like prophages Pnm1, Pnm2, MuMenB (in N. meningitidis). More than 44% of the observed rearrangements most likely occurred with the participation of mobile elements, including prophages. No differences were found between the Russian and global N. gonorrhoeae population both in terms of rearrangement events and in the number of transposable elements in genomes.
Electron Tunneling in Biology: When Does it Matter?
Authors: Sarhangi Setare M. , Matyushov Dmitry V.
Published: November 2022

Electron can tunnel between cofactor molecules positioned along biological electron transport chains up to the distance of ≃20 Å on the millisecond time scale of enzymatic turnover. This tunneling range mostly determines the design of biological energy chains facilitating cross-membrane transport of electrons. Tunneling distance and cofactors’ redox potentials become main physical parameters of this design. The protein identity, flexibility, or dynamics are missing from this picture assigning universal charge-transport properties to all proteins. This paradigm is challenged by dynamical models of electron transfer showing that the hopping rate is constant within the crossover distance R*≃12 Å, followed with an exponential tunneling falloff at longer distances. In this view, energy chains for electron transport are best designed by placing redox cofactors near the crossover distance R*. Protein flexibility and dynamics affect the magnitude of the maximum hopping rate within the crossover radius. Protein charge transport is not driven by universal parameters anymore and protein identity matters.
How Do Variable Fertilizer and Irrigation Treatments Impact Greenhouse Gas Fluxes from an Aridland Agroecosystem?
Authors: Duval Benjamin , Martin Jamie , Marsalis Mark A.
Published: November 2022

Greenhouse gas (GHG) emissions from agriculture are significant contributors to global change. We experimentally manipulated biogeochemical control points of irrigation and nitrogen (N) to examine management strategies that could impact GHG flux, i.e., carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O) and soil physiochemical changes over a growing season in an arid New Mexico sorghum (Sorghum bicolor (L.) Moench) cropping system. Sorghum is water and N efficient and amenable to environmental stress. Interrogating how crop systems perform in intense heat, aridity and ultraviolet stress of the southwestern US climate can inform future management in areas that produce more food currently, but that will undergo these stresses in the near future. Water was applied at regionally typical rates, or at ~30% below those rates. Timing N to plant needs may reduce N loss and N2O emissions, and we tested this hypothesis by adding equal amounts of fertilizer to all plots, with half receiving all fertilizer at planting versus plots fertilized at 50:50 planting and 30 days post-planting. Gas flux from soil was analyzed via FTIR. More biomass was harvested from the fully irrigated plots; N timing did not significantly affect biomass. Soil pH fluctuated throughout the season in response to both treatments. Carbon dioxide emissions significantly increased in fully irrigated plots through time. Methane uptake was depressed by full irrigation. Nitrous oxide flux was lower in split N plots, but N2O emissions were not impacted by reduced irrigation. These results suggest that arid adapted crops can maintain economically feasible yield, and biogeochemical monitoring within a growing season can help manage for GHG flux.
Methylidyne Cavity Ring-Down Spectroscopy in a Microwave Plasma Discharge
Authors: Nemes László , Parigger Christian
Published: November 2022

This work communicates cavity ring-down spectroscopy (CRDS) of methylidyne (CH) in a chemiluminescent plasma that is produced in a microwave cavity. Of interest are the rotational lines of the 0-0 vibrational transition for the A-X band and the 1-0 vibrational transition for the B-X band. The reported investigations originate from CH-radical research in 1996 that constituted the first case of applying CRDS to the CH radical. The report also includes recent analysis that shows excellent agreement of measured and computed data, and it communicates CH line strength data.
RePlant Alfa: Integrating Google Earth Engine and R coding to Support the Identification of Priority Areas for Ecological Restoration
Authors: Morales Narkis S , Fernández Ignacio C , Durán Leonardo P , Pérez Waldo A
Published: November 2022

Land degradation and climate change are among the main threats to the sustainability of ecosystems worldwide. Therefore, the restoration of degraded landscapes is essential to maintain the functionality of ecosystems, especially those with greater social, economic and environmental vulnerability. Nevertheless, policy-makers are frequently challenged by deciding on where to prioritize restoration actions, which usually includes to deal with multiple and complex needs under an always short budget. If these decisions are not taken based on proper data and processes, restoration implementation can easily fail. To help decision-makers taking informed decisions on where to implement restoration activities, we have developed a semiautomatic geospatial platform to prioritize areas for restoration activities based on ecological, social and economic variables. This platform takes advantage of the potential to integrate R coding, Google Earth Engine cloud computing and GIS visualization services to generate an interactive geospatial decision-maker tool for restoration. Here, we present a prototype version called "RePlant alpha" which was tested with data from the Central Zone of Chile. This exercise proved that integrating R and GEE was feasible, and that the analysis, with at least six indicators and for a specific region was also feasible to implement even from a personal computer. Therefore, the use of a virtual machine in the cloud with a large number of indicators over large areas is both possible and practical.
Screening Aromatic Rice Genotypes by RAPD Markers for Breeding Salinity Stress Tolerant Rice Variety
Authors: Azim Md Abdul , Rahman Md Mahbubur , Gupta Dipali Rani , Sarker Aniruddha , Islam Tofazzal
Published: November 2022

Salinity is abiotic stress, which causes adverse environmental conditions for rice cultivation. In particular, local aromatic rice cultivation is heavily influenced by soil salinity stress, which has an impact on global food security. This study aimed to screen local aromatic rice genotypes in a hydroponics experiment using Yoshida solutions to evaluate the effect of increasing NaCl concentrations on the early growth stages of rice seedlings. Genetic diversity along with phylogenetic relationship was assessed using the random amplified polymorphic DNA (RAPD) markers. Out of 20 RAPD markers, 17 markers produced reproducible polymorphic bands. Individuals of all genotypes shared 88 (89.80%) of the 98 total RAPD elements amplified. The genetic distance-focused similarity index ranged from 0.05 to 0.94. The highest genetic distance (0.94) was discovered between genotypes Nayanmoni and Kalijira Barisal, and the lowest was between Badshabhog and Kataribhog (0.05). In addition, the OPS 3(510bp) and OPA 14(1100bp) markers could be used to identify salt-tolerant genotypes. According to genetic distance, the salt stress tolerant check genotype, Pokkali was genetically related to Chinigura as well as Kalijira Barisal. This study established a simple and consistent method for evaluating variability across various aromatic rice genotypes, which will benefit in genotype selection for breeding salinity stress tolerant aromatic rice varieties in Bangladesh.
Hydrogen Evolution Volcano(es) – From Acidic to Neutral and Alkaline Solutions
Authors: Gebremariam Goitom K. , Jovanović Aleksandar Z. , Dobrota Ana S , Skorodumova Natalia V. , Pašti Igor A.
Published: November 2022

As the global energy crisis continues, efficient hydrogen production is one of the hottest topics these days. In this sense, establishing catalytic trends for hydrogen production is essential for choosing proper H2 generation technology and catalytic material. Volcano plots for hydrogen evolution in acidic media are well-known, while volcano plot in alkaline media was constructed ten years ago using theoretically calculated hydrogen binding energies. Here we show for the first time that the volcano-type relationships are largely maintained in a wide range of pH values, from acidic to neutral and alkaline solutions, using theoretically calculated hydrogen binding energies on clean metallic surfaces and experimentally measured hydrogen evolution overpotentials. If metallic surfaces are exposed to high anodic potentials, hydrogen evolution can be boosted or significantly impeded, depending on the metal and the electrolyte in which the reaction occurs. Such effects are discussed here and can be used to properly tailor catalytic materials for hydrogen production via different water electrolysis technologies.
The impact of BMI on Ovarian Cancer- An Updated Systematic Review and Metanalysis
Authors: Tzenios Nikolaos , Tazanios Mary , Chahine Mohamed
Published: November 2022

A significant number of research studies have focused on determining whether BMI influences various types of cancer. The findings of these studies showed that people have to manage their BMIs to decrease their risk of developing various types of cancer, one of which is ovarian cancer. A PRISMA guideline for systematic review and meta-analysis was used to identify 20 research studies related to the topic to establish the truth or falsity of the findings. Later, their findings were synthesized. The synthesis of the findings of such research articles suggests that overweight and obesity increase an individual’s risk of developing ovarian cancer and experiencing severe symptoms of the disease. In such a manner, the current research study can conclude that effective management of BMI is necessary for decreasing the prevalence and mortality rates associated with ovarian cancer.
Experimental Study on Failure Model of Tailing Dam Overtopping under Heavy Rainfall
Authors: Wang Guangjin , Zhao Bing , Lan Rong , Liu Dianwen , Wu Bisheng , Li Yaoji , Li Quanming , Zhou Hanmin , Liu Mingsheng , Liu Wenlian , Liu Xinjie
Published: November 2022

Unusual rainfall is the primary cause of the failure of the tailing dams, and overtopping is the most representative model of the tailing dam failure. The upstream tailing dam was selected as the research object to study the whole process of breach extension and the overtopping dam-failure mechanism under the full-scale rainfall condition. The results showed that the significant size grading phenomenon in the front, middle, and end of the tailing pond was obvious due to the flow separation effect, and its average particle diameter was D50. At different moments of rainfall, the height of the infiltration line at different positions of the dam body was different; at the rainfall of 3600 s, the height of the infiltration line lagged behind the height of the tailing pond, and this phenomenon from the tail of pond to the outside of the dam slope became more obvious. After the rainfall of 3600 s, the height of the infiltration line lagging behind the water level in the pond basically disappeared, and the rate of infiltration line rise kept pace with the rate of water level. The process of overtopping dam-failure experienced dam overtopping (gully erosion), formation of a multistepped small “scarp,” breach rapid expansion, formation of large “scarp,” and burst (fan-shaped formation). The width and depth of the breach showed a positive correlation, and the widening rate of the breach was 3 to 8 times of the deepening rate, especially in the middle of the dam break, widening behavior occupied the dominant factor. The shape of the dam body after failure was parabolic, and the dam body had obvious elevation changes. These results provide the theoretical guidance and engineering application value for improving the theory and early warning model of the upstream tailing dam.