bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Ekstrak Bunga Kembang Sepatu (Hibiscus Rosa-Sinensis Linn.) terhadap Jumlah, Motilitas, Morfologi, Viabilitas Spermatozoa Tikus Jantan
Authors: Julia Dina , Salni Salni , Nita Sri
Published: May 2020

Partisipasi laki-laki dalam KB masih relatif rendah bila dibandingkan dengan keikutsertaan perempuan. Salah satu tanaman obat tradisional yang digunakan adalah  bunga kembang sepatu yang bersifat antifertilitas. Penelitian ini bertujuan untuk menguji pengaruh ekstrak bunga kembang sepatu  terhadap jumlah, motilitas, morfologi dan viabilitas spermatozoa tikus jantan (Rattus norvegicus). Penelitian ini merupakan penelitian eksperimental dengan menggunakan Rancangan Acak Lengkap (RAL). Sampel dalam penelitian ini menggunakan 25 tikus jantan strain Sprague Dawley usia 60-70 hari dengan berat badan 200-210 gram. Lama perlakuan 30 hari dengan dosis 200 mg/kgBB, 300 mg/kgBB, 400 mg/kgBB. Data disajikan dalam bentuk tabel dan diagram serta narasi untuk  menginterpretasikan data tersebut. Hasil penelitian ini menunjukkan adanya penurunan jumlah sperma pada kelompok perlakuan dibanding kelompok kontrol (p=0,000), terjadi penurunan motilitas sperma (p=0,001), terjadi peningkatan morfologi abnormal (p=0,000), dan terjadi penurunan viabilitas spermatozoa antara kelompok perlakuan dibanding kelompok kontrol (p=0,000). Dapat disimpulkan  bahwa ada perbedaan bermakna dari pengaruh ekstrak bunga kembang sepatu terhadap jumlah, motilitas, morfologi, viabilitas spermatozoa.
Efektivitas Ekstrak Etanol Daun Salam (Eugenia polyantha) terhadap GLUT 4 di Jaringan Adiposa dan Kadar Gula Darah Puasa pada Tikus Putih Jantan
Authors: Zanaria Rima , Kamaluddin MT , Theodorus Theodorus
Published: May 2020

Diabetes Mellitus merupakan penyakit epidemik global, cenderung meningkat dengan berbagai kondisi patologis yang menyertainya, sehingga membutuhkan preparat baru yang poten,tidak toksik, efektif dalam  pemberian dan harga terjangkau untuk mengevaluasi efektivitas ekstrak etanol dalam daun salam (Eugenia polyantha) terhadap GLUT 4 di jaringan adiposa dan kadar gula darah puasa tikus putih jantan galur wistar (Rattus norvegicus) yang diinduksi diet tinggi lemak (HFD-dexamethasone. Desain penelitian ini adalah ekperimental, rancangan pre dan post test dengan kelompok kontrol dilakukan di Animal house Fakultas Kedokteran Universitas Sriwijaya. Tiga puluh enam ekor  tikus dengan berat antara 150 - 200 gram secara acak dibagi menjadi 6 kelompok. Setelah di aklimatisasi selama 7 hari dan diinduksi dengan high fat diet 5 ml per oral serta dexamethasone  250 µg/kgbb intraperitoneal selama 35 hari. Kelompok kontrol (-) diberi larutan aquades sebanyak 2 ml, kelompok pertama diberi ekstrak ethanol daun salam dosis 62,5 per kilogram berat badan, kelompok kedua  diberi ekstrak ethanol daun salam dosis 125 mg per kilogram berat badan,  kelompok ketiga diberi ekstrak etanol daun salam dosis 250 mg per kilogram berat badan,  kontrol (+) diberi Pioglithazone dosis 0,02 gram per kilogram berat badan. Semua perlakuan diberikan selama 14 hari. Data diperoleh dengan analisis ANOVA dan post hoct test spss versi 18. Induksi HFD /dexamethasone pada tikus selama 35 hari menujukan peningkatan kadar glukosa darah secara signifikan lalu tikus dieutanasia dengan ketamin 70 mg/kgbb intraperitoneal lalu dilakukan autopsi dan diambil jaringan adiposa. Intervensi ekstrak ethanol daun salam selama 14 hari pada tikus diabetes mellitus efektif meningkatkan kadar GLUT 4 di jaringan adiposa (p<0,05) dibanding kontrol negatif dan Pioglitazone, Ekstrak etanol daun salam dosis 125 mg per kilogram berat badan tikus  merupakan dosis paling efektif dalam meningkatkan GLUT 4 dijaringan adiposa, sedangkan dalam menurunkan kadar gula darah puasa dosis 62,5 mg/kgbb tikus, 125 mg/kgbb tikus,250 mg/kgbb tikus sama efektifnya dengan kontrol positif obat pioglithazone. Ekstrak etanol daun salam  (Eugenia polyantha) berpotensi meningkatkan kadar GLUT 4 di jaringan adiposa tikus dan menurunkan kadar gula darah puasa pada tikus putih jantan (Rattus norvegicus) galur wistar yang diinduksi HFD/dexametasone. Kata kunci : Ektrak Etanol daun salam, HFD/Dexamethasone, GLUT 4 di jaringan adiposa, in Vivo
IFN-Gamma Secretion and IL-10 after Stimulation of ESAT-6-CFP-10 (EC610) Fusion Antigen in Patients with Active Tuberculosis and Latent Tuberculosis
Authors: Prihantika S. Sabrina , Kurniati Nova , Rahadiyanto Kemas Ya'kub , Saleh M Irsan , Hafy Zen , Tanoerahardjo Francisca Srioetami , Nugraha Jusak , Salim Eddy Mart
Published: May 2020

Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis which is still a health problem in the world including in Indonesia. TB infection arises due to interference with the regulation of the body's defense system. Cellular immune system plays a role in fighting TB infection, namely the role of T lymphocytes that differentiate into Th1 cells secrete pro-inflammatory cytokines IFN-? and Th2 cells that secrete IL-10 anti-inflammatory cytokines. The EC610 fusion antigen is specific and has a strong antigenicity to T cell stimulation. The aim of the study was to determine differences in the mean levels of IFN-? and IL-10 after EC610 antigen stimulation in patients with active TB and latent TB. The design of this study was a quasi-in vitro experiment with PBMC culture stimulated by EC610 antigens in the active TB and latent TB groups. The research and examination were carried out at the South Sumatra Province SSR and the Health Research and Development Laboratory Center, Central Jakarta. There were 21 subjects with active TB and 28 subjects with latent TB who met the inclusion criteria. Measurement of IFN-levels? and IL-10 was performed using ELISA-Reader. The results showed the levels of IFN-? and IL-10 after EC610 antigen stimulation were higher in active TB than latent TB. High levels of IFN-? active TB patients showed protective immune responses against M.tb germs while high levels of IL-10 showed their role as anti-inflammatory. There is no significant difference in the average level of IFN-? in patients with active TB and latent TB (p = 0.769) and there was a significant difference in the level of IL-10 levels after EC610 antigen stimulation was higher in active TB than latent TB (p = 0,000).
EVOLUSI KARDIOLOGI SEBAGAI ILMU PENGETAHUAN: TINJAUAN PUSTAKA
Authors: Edo Tondas Alexander , Anwar Chairil , Agustian Rolando
Published: May 2020

Science is a conscious effort to try, find and improve human understanding from various aspects in human nature. The number of medical specialties continues to grow until they reach even smaller branches known as sub-specialties. One type of specialization in medical science is the specialization of cardiology, the science that focuses on the needs of the heart organ. The development of cardiology cannot be separated from the history behind it. The progress of cardiology up to this point is a continuous interrelated journey. Every lesson in the past will be a capital for future experience, as will cardiology, where each phase becomes the foundation for future development.
Factors Affecting Thickening of Carotid Intima Media Thickness in Patients with Chronic Kidney Disease
Authors: Yonata Ade , Ali Zulkhair , Indrajaya Taufik , Effendi Ian , Suhaimi Novadian
Published: May 2020

Chronic kidney disease (CKD) is associated with high mortality rates related to cardiovascular complications. Atherosclerosis, arteriosclerosis and vascular calcification conditions are often found in CKD patients. Carotid intima media thickness (cIMT) thickening is one of the parameters of vascular disorders. A cross sectional study was conducted on patients with chronic kidney disease in the hospital. Mohammad Hoesin Palembang. Patients' blood samples were examined in the hospital laboratory. CIMT thickening was examined using echocardiography. A total of 55 patients with stage 3-5 chronic kidney disease were examined. The median cIMT is 0.8 (0.6-1.45) mm. Spearman's correlation analysis showed a significant correlation between triglyceride levels and thickening of cIMT (r = 0.303, p = 0.025). A significant correlation was also shown between phosphate levels and cIMT thickening (r = 0.290, p = 0.032). There is a significant correlation of triglyceride levels and phosphate levels to cIMT thickening in patients with chronic kidney disease in Palembang
ANALISIS PENGARUH EASY OF USE, QUALITY OF INFORMATION TERHADAP TRUST DAN REPURCHASE INTENTION E-TICKET PADA APLIKASI TRAVELOKA
Authors: Wiwoho Gunarso
Published: May 2020

The purpose of this study is to analyze the effect of easy of use, quality of information on trust, and repurchase intention e-ticket on the Traveloka application in Kebumen Regency. The study was conducted using populations originating from people living in Kebumen Regency and had transacted using Traveloka with a sample size of 100 respondents. The analytical method used in this study consisted of descriptive and quantitative analysis with the type of determination of respondents through purposive sampling. Analysis carried out through quantitative methods is the validity test, reliability test, classical assumption testing, t-test, determination coefficient test, path analysis, and Sobel test. The results showed that based on the validity and reliability tests all variables were declared valid and reliable. Based on the t-test the easy of use variable significantly affects trust, quality of information significantly influences trust, easy of use significantly influences repurchase intention, quality of information, and trust has an effect on repurchase intention. The Sobel test shows that trust cannot mediate easy of use with repurchase intention and trust can mediate the quality of information with repurchase intention.
Species composition and methicillin resistance of staphylococci taken on dairy farms
Authors: Horiuk Y. V. , Kukhtyn M. D. , Salata V. Z. , Horiuk V. V.
Published: May 2020

Methicillin-resistant staphylococci can often asymptomatically colonize animals and humans and are capable of causing disease in them. Therefore, their identification and species identification are important for establishing the source of zoonotic infection and the reservoirs of antimicrobial resistance genes. The purpose of the search was to study the spread of methicillin-resistant staphylococci on dairy farms in the Western region of Ukraine. BD Baird-Parker Agar (HiMedia, India) was used to isolate staphylococci. Specific identification of pure cultures was performed using “RapID Staph Plus” kits (Oxord, UK). Staphylococcus sensitivity to methicillin was determined by inoculum application on Muller-Hinton agar with oxacillin (HiMedia, India). The sensitivity of the isolates to antibacterial preparations was determined by disco-diffusion method. The results of our searches show that Staphylococcus aureus is virtually identical in the amount both from cows (50.1 %) and from humans (62.4 %). In this case the frequency of its isolation among other species was 20.3 %. Along with Staphylococcus aureus there are such species as: S. haemolyticus (20.3 %), S. saprophyticus (13.6 %), S. xylosus (14.0 %), S. chromogenes (11.1 %), S. sciuri (8.8 %), S. epidermidis (4.8 %), S. hominis (3.4 %), S. cohnii (2.6 %) and S. warner (0.7 %). In this case, approximately the same irradiation of cows, humans and the environment by species S. haemolyticus (44.5:70.8:58.8 %), S. epidermidis (12.7:16.6:9.1 %), S. xylosus (26.0:37.4:52.9 %) is observed. The share of S. aureus strains on methicillin-resistant dairy farms in the Western Ukraine is 26.8 %. The proportion of S. aureus strains on methicillin-resistant dairy farms in the Western Ukraine is 26.8 %. Methicillin resistance is also shown S. haemolyticus, S. saprophyticus, S. xylosus та S. chromogenes. In this case their number is 1.1, 1.3, 1.6 and 5.5 times lower, respectively, and S. hominis 1.2 times higher than S. aureus. In addition, the selected cultures simultaneously show resistance to two or more antibiotics. Thus, staphylococci circulating on dairy farms are a large reservoir of resistance genes of antimicrobial preparations. Therefore, it is necessary to establish a constant control of the secretion of staphylococci resistant to β-lactam antibiotics.
Analysis of radiouclide contamination of forestry products on the territory of Ukraine 2013–2019
Authors: Malimon Z. V. , Salata V. Z. , Kochetova G. S. , Prokopenko T. O. , Gusak L. M.
Published: May 2020

The analysis of the results of radiological studies of food and feed conducted by the specialists of the state laboratories of the State Consumer Service for 2013–2019 is performed. The analyzed results show that in the territories assigned to the radiation contamination zones, samples with a radionuclide content exceeding the maximum admissible levels of 137Cs and 90Sr are constantly detected. Even 33 years after the Chernobyl accident, the specific activity of 137Cs in mushrooms and berries remains high. Specialists of the state laboratories of the State Consumer Service during this period carried out radiological examinations of food and feed for the contents of 137Cs and 90Sr. Exceedance of the maximum permissible levels (DR) of 137Cs was detected in 3.253 samples, of which 1.277 were fresh mushrooms and yagi and 729 were dried and dried mushrooms and berries. It is established that forest mushrooms and berries (fresh and dried) are the critical dose-forming foods, accounting for the largest proportion of about 62 % of the total positive samples. A much better situation was observed in detecting an excess of DR 90Sr. During the study period, contamination of 90Sr food and feed is of a single nature. The dynamics of detecting excesses of DR 137Cs in forest mushrooms and berries (fresh and dried) for 2013–2019 have significant fluctuations related to environmental conditions and the multidirectional migration of man-made radionuclides in forest ecosystems. The use, even in small quantities, of forest origin products with a maximum specific activity of 137Cs can play a significant role in the internal exposure of long-lived radionuclide to the local population. Therefore, the largest proportion of forest food products (62 %) is in the balance of radionuclide-contaminated products during the last seven years. (2013–2019) and other products and feeds are the basis for further radiological control by their state laboratories of the State Consumer Service.
Morphological particulars of the liver of laying hens of cross “Lohmann Brown” under hepatosis
Authors: Yaremchuk V. Y. , Slivinska L. G. , Stronskyi Y. S.
Published: May 2020

The article presents the results of histological examinations of the liver of laying hens at age 166, 300 and 530 days, in which according to the results of biochemical analysis of blood serum revealed a subclinical course of hepatosis. The purpose of our study was the early diagnosis of this pathology and the study of the histological structure of the liver in different periods of poultry productivity. The work was performed at LLC Agro Firm “Zagai” of Kamianka-Buzkyi district of Lviv region. Autopsy and examination of histological specimens were performed at the Department of Normal and Pathological Morphology and Forensic Veterinary at Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv. The macroscopic examination of the liver showed that in part of laying hens at 166 days of age, in most of laying hens at 300 days old and in all of laying hens at 530 days old examined, the liver was slightly enlarged, of a sluggish consistency and unevenly colored. It should also be noted that, in addition to severe dystrophic changes in the liver, 530 days of laying hens also showed signs of general obesity. The study of histological specimens installed that in part of laying hens at 166 days of age, the liver lobules were disordered, in resulting was disrupted their beam structure. At the same time, cytoplasm of hepatocytes is somewhat cloudy and visible granularity. In laying hens at age 300 and 530 days installed the discomplexation of the beam structure of the organ and the presence of small and large droplets of fat vacuoles in hepatocytes are indicated, which indicate about the development of fatty dystrophy. The results of the morphological study indicate the presence in the liver of laying hens signs of acute and chronic pathological processes, which with age are complicated by dystrophic changes of the organ.
Akhlak Tasawuf Basis Pendidikan Multikultural Di Indonesia
Authors: Rajab Hadarah Rajab
Published: May 2020

Penelitian ini bertujuan untuk mendeskripsikan bagaimana sikap aklah yang diajarkam ilmu tasawuf dapat menjadi landasan Pendidikan multicultural. Metode yang digunakan adalah dengan metode penelitian kualitatif fenomenologis, dengan melalui pendekatan wawancara mendalam dan pengamatan langsung di lapangan, serta observasi. Adapaun hasil dari pene;itian ini adalah  desain Pendidikan Multikultural  yang  berbasis Akhlak Tasawuf. Kolaborasi antara konsep pendidikan multicultural di satu sisi dan perilaku sufi  pada ajaran tasawuf dilain sisi. Pada dasarnya kedua unsur tersebut sudah berjalan dengan waktu yang cukup panjang dan telah merimplikasi ke berbagai aspek[1], namun pada bagian ini menawarkan kolaborasi kedua unsur dalam sistim pendidikan multikulturak berdimensi sufi[2] yang dimungkinkan menjadi suatu pola baru yang lebih teduh dan menciptakan kedamaian untuk bangsa Indonesia

This study aims to describe how the attitude that is taught by Sufism can be the basis of multicultural education. The method used is phenomenological qualitative research methods, through in-depth interviews and direct observation in the field, as well as observation. The results of this study are the design of Multicultural Education based on Moral Tasawuf. Collaboration between the concept of multicultural education on the one hand and Sufi behavior on Sufism on the other hand. Basically these two elements have been running for quite a long time and have been implicated in various aspects, but this section offers collaboration between the two elements in a multicultural education system with a Sufi dimension which is possible to become a new pattern that is more shady and creates peace for the Indonesian people

 

[1] Hadarah and Gani, ‘The Implementation of Tarekat Naqsyabandiyah’s Sufism Values in South Celebes’.

[2] Enok Rohayati, ‘Pemikiran al-Ghazali tentang Pendidikan Akhlak’, Ta’dib: Journal of Islamic Education (Jurnal Pendidikan Islam), vol. 16, no. 01 (2011), pp. 93–112.
About agricultural manuals, gardens and coffee plantations: mosaics and landscape transformation in the Paraiba do Sul Valley, Brazil
Authors: Santa Cruz de Assis Brasil Lucas , Oliveira Rogério Ribeiro de
Published: May 2020

Economic cycles have often become the landscape matrix, in a hybrid process of society-nature transformation, leaving distinct legacies in it. The coffee plantation showed great productivity in the Paraíba do Sul Valley to the detriment of forests, resulting in profound changes in geo-hydric cycles. Although the transformation by coffee has been significant on a spatial scale and in environmental changes, the Paraíba do Sul Valley landscape needs to be understood in a broader perspective. There were also other crops in the landscape inside or outside large estates. This work aims to recognize the spatial organization of these cultures and develop an understanding of the pattern of the coffee landscape, showing the performance of different social actors. The methodology consisted of a bibliographic review and analysis of historical agricultural manuals. Spatializing such past activities and social groups in the landscape shows us what was previously hidden, omitted by the traditional historical narrative This research showed that colonial knowledge developed a landscape compartmentalization, spatializing the crops according to pedological and topographic evidence.
Whole-slide image analysis of the tumor microenvironment identifies low B-cell content as a predictor of adverse outcome in patients with advanced-stage classical Hodgkin lymphoma treated with BEACOPP
Authors: Ron Daniel Jachimowicz  , Luise Pieper  , Sarah Reinke  , Artur Gontarewicz  , Annette Plütschow  , Heinz Haverkamp  , Leonie Frauenfeld  , Falko Fend  , Mathis Overkamp  , Franziska Jochims  , Christoph Thorns  , Martin Leo Hansmann  , Peter Möller  , Andreas Rosenwald  , Harald Stein  , Hans Christian Reinhardt  , Peter Borchmann  , Bastian von Tresckow  , Andreas Engert  , Wolfram Klapper
Published: May 2020

A subset of patients with advanced-stage classical Hodgkin Lymphoma (cHL) relapse or progress following standard treatment. Given their dismal prognosis, identifying this group of patients upfront represents an important medical need. While prior research has identified characteristics of the tumor microenvironment, which are associated with cHL outcomes, biomarkers that are developed and validated in this high-risk group are still missing. Here, we applied whole-slide image analysis (WSI), a quantitative, large-scale assessment of tumor composition that utilizes conventional histopathology slides. We conducted WSI on a study cohort with pre-treatment biopsies of 340 advanced-stage cHL patients enrolled in the HD12 and HD15 trials of the German Hodgkin Study Group (GHSG), and tested our results in in a validation cohort of 147 advanced-stage cHL patients within the GHSG HD18 trial. All patients were treated with BEACOPP-based regimens. By quantifying T cells, B cells, Hodgkin-Reed-Sternberg-cells and macrophages with WSI, 80% of all cells in the tumor tissue were identified. Crucially, low B cell count was associated with significantly reduced progression-free survival (PFS) and overall survival (OS), while T cell-, macrophage- and Hodgkin-Reed-Sternberg-cell content was not associated with the risk of progression or relapse in the study cohort. We further validated low B cell content as a prognostic factor of PFS and OS in the validation cohort and demonstrate good inter-observer agreement of WSI. WSI may represent a key tool for risk stratification of advanced-stage cHL that can easily be added to the standard diagnostic histopathology work-up.
Analysis of Superior Commodities in Agricultural Sector in Some Districts of North Sumatera Province
Authors: Lubis Nela Permata Sari , Nugrahadi Eko Wahyu , Yusuf M.
Published: May 2020

Realization of regional economic development requires policies that are endogenous development. Each region has a base sector as the main driving force in economic growth. The base sector must have resilience between other sectors and have a high contribution to the formation of total regional economic output. North Sumatra is one of the provinces in Indonesia which has a tendency towards economic structure in the agricultural sector. Viewed from the field of business, the agricultural sector provides the highest contribution in the formation of GRDP. North Sumatra has 25 districts with a variety of geographical conditions having varied natural resources that need to be intensified and explored. The purpose of this study is to analyze the leading commodities of the agricultural sector and find out how much the impact of the leading sector on the growth of North Sumatra GRDP in the period 2014 - 2018. The method of analysis in this study uses the Location Quotient (LQ) analysis, Revelead Comparative Advantage (RCA) analysis, and Panel Data Regression Analysis. The estimation results show that the agriculture, livestock, hunting and services sub-sectors, the forestry sub-sector and the fisheries sub-sector have a positive and significant effect on the economic growth of the province of North Sumatra. The economic growth variables can be explained by 89 percent by the variables of the agriculture, livestock, hunting and service subsectors, the forestry subsector and the fisheries subsector while the rest are explained by variables not included in this study.
The Difference between in a 5K race running on the Tartan Track and the Asphalt Road Track against the Injury Risk on the Men Athletic Club of Dragon and Pandawa Salatiga
Authors: Sari Nugrahani Febrina , Kristiyanto Agus , Sabarini Sri Santoso
Published: May 2020

The purpose of this study was to determine the difference between 5K long distance running on the Tartan track and the Asphalt Highway on the risk of injury to the Men’s Athlete Club of Dragon Athletics and Pandawa Salatiga. This study uses a descriptive qualitative research method using an ex post facto approach in which data taken on respondents based on events that have been experienced before. The number of samples was 14 Men’s Athlete of Pandawa Club and 10 Men’s Athlete of Dragon Salatiga Club. The total number of samples was 34 athletes and samples were taken using purposive sampling technique. Data collection techniques using Triangulation techniques, namely questionnaire or questionnaire, interviews and documentation. The validity of the questionnaire test or questionnaire was carried out and agreed upon by experts in the field of running injuries and linguists (Expert Judgment) and the hypothesis was tested using the Chi Square test with SPSS. Observation was carried out for four weeks by taking data through questionnaires and interviews by researchers to respondents or research samples namely athletes and trainers. The results of this study indicate that the asphalt highway running track has a higher risk of injury than running on the tartan track. Asphalt highway has a hard structure on the surface, when running footstool meets a hard surface so this will cause the risk of injury to the foot such as archilles tendinitis injuries where large tendon muscles behind the ankles that connect the calf muscles to the heel bones experience irritation or inflammation. Knowing the risk of injury that occurs in certain types of trajectories can help athletes and coaches in designing training programs and minimize injury.
Social Engagement as an Initial Capital for the Development of Civic Engagement Students in Boarding Schools
Authors: Saputra Ikrimah , Muchtarom Moch. , Triyanto Triyanto
Published: May 2020

Civic engagement is defined as the active participation of citizens individually or collectively in community life based on skills, expertise, knowledge, which combines with values, motivation and commitment to make changes in order to improve the quality of people's lives for the better. The progress of information technology and the very rapid development of science in the current era of globalization, have a negative impact on social change in society. Today's young generation tends to be individualistic and hedonistic. They focus life orientation more on self-achievement rather than being involved in social problems in society. Boarding schools are a suitable environment in an effort to develop civic engagement, especially among boarding students because they have a good social attachment to one another. This study aims to find out how social engagement of students in boarding schools is an important initial capital for the development of civic engagement. This research uses a qualitative method using purposive sampling technique. The subjects of this study include Civics Education teachers, Boarding Advisors, and students. Data collection was carried out using document study techniques, interviews, and observations. Data analysis technique is done by data reduction, data presentation, drawing conclusions, and verification. The results of this study indicate that social engagement among boarding students is influenced by factors of fate, equality of interest, and the presence of intense and continuing interactions. This social attachment is the initial capital for the development of civic engagement, especially in the stages of growing empathy.
Development of PPKn Module for the Love of the Environment Material Using Example Non Example Learning Model to Increase Student Learning Activities in Class II Public Elementary School 040446 Kabanjahe T.P. 2018/2019
Authors: Ginting Sari Jusnita Br , Ruslan Dede , Rahman Arif
Published: May 2020

This study produced a PPKn module on environmental love by using the example non example learning model to increase student learning activities. The research method used is the Research and Development method which refers to the development of Borg and Gall (in Tegeh et al, 2014: 7-13). The module development process is carried out with three stages, namely the preliminary study stage, initial product development and product trials. The results of the study show that the assessment of eligibility by material experts obtained an average of 91.6%, the feasibility assessment by linguists obtained an average of 92, 1%, Feasibility assessment by design experts obtained an average of 80%. Individual trials with an average of 80.5% in the good category, small group trials with an average of 85.4% in the excellent category, and limited field trials with an average of 88.4% in the very good category. The results of observations of student activities observed an average of 92.4%, The results of observations of student activities asked an average of 85.6%, The results of observations of student activities tried with an average of 84.9%, The results of observations of student activities associated with reasoning an average of 89.4%, the results of observations of student activities communicate with an average of 83.9%. The average score at 69.8 pretest and 82.3 at posttest. This proves that the PPKn module of environmental love material by using the example non example learning model is feasible, easy, and effective for use in class II grade students. This research has implications for the use of the PPKn module on environmental love material by using the example non example learning model to increase student activity and activity
Spatial Modeling of Social Expenditure in EU Countries
Authors: Monika Miśkiewicz-Nawrocka  , Katarzyna Zeug-Żebro
Published: May 2020

The age structure of EU countries has changed significantly in recent years. These changes are mainly due to longer life expectancy, low fertility rates, and population migrations. Countries are trying to cope with the consequences of demographic changes by reforming the social care system, extending the retirement age, introducing additional social benefits promoting parenthood and supporting large families. Social security programs in EU countries are very diverse. The financial aspect plays an important role in social security systems. Social security is based on the redistribution of income between persons receiving remuneration from work and persons who, due to reaching retirement age, poor health, lack of employment or having many children receive social benefits. In view of the changing demographic situation, social security functions such as health care, pensions and benefits for large families require Member States to take immediate structural and financial change. In the study will carry out spatial analysis of social care system development in the European Union and will research the impact of social spending on the unemployment rate, household structure, birth rate or poverty level. In addition, the forecast of social expenditure in the EU will be designated. The use of spatial analysis will allow to determine the existing relations between the studied countries due to the level of development of the studied phenomenon. The analysis will be carried out on the basis of actual data from Eurostat.
Analysing How the Shift in Discourses on Social Media Affected the Narrative Around the Indian General Election 2019
Authors: Devansh Manu  , Radhika Krishnan  , Ponnurangam Kumaraguru
Published: May 2020

The Lok Sabha Elections 2019 in the world’s largest democracy, India, was the biggest electoral event on the planet. These elections are key in the selection of the Prime Minister, the highest authority in the cabinet. Keeping in pace with the global trend, the Indian elections saw a very prominent use of Online Social Media by political parties to create a major discourse around the event. We focus our study on Twitter, collecting over 45 Million tweets, tracking more than 3500 hashtags and over 2500 political handles while monitoring their network interactions. In this work, we have analysed tweets from all these political handles to see how narratives were shaped and altered over time. We study these narratives formed by the party already in power and how they were supported or challenged by other parties. Spanning over 5 months, January to May 2019, we analysed the monthly changes in the rhetoric created by the leading political parties and leaders. We then discern the impact of these changes on existing narratives during the campaigning and the elections.
Foraging success in planktivorous fish increases with topographic blockage of prey distributions
Authors: Aarflot JM , Dalpadado P , Fiksen Ø
Published: May 2020

Banks and shelves are productive zones of the ocean, and often home to large fish stocks. Can shallower bottom topographies improve foraging opportunities for pelagic fish by blocking zooplankton from hiding in deep, darker water? We use mechanistic principles of visual prey search and an extensive dataset of zooplankton depth distributions to model foraging success in planktivorous fish across a large marine ecosystem. Our results show that zooplankton distribute deeper with deeper bathymetry, and that fish find exponentially less food with increasing bottom depths. Over shallow banks, zooplankton are forced into higher light exposure, providing higher prey encounter rates for fish despite lower abundance of prey. Stomach data analyses from a key planktivore support these predictions and suggest that fish foraging on copepods are more successful over shallower grounds. Our study demonstrates that prey availability for planktivorous fish is not proportional to zooplankton abundance, while the bottom depth is an important factor in fish foraging success and zooplankton mortality rates.
Is serum TWEAK a useful biomarker of neuropsychiatric systemic lupus erythematosus?
Authors: Balajkova V. , Olejarova M. , Moravcova R. , Kozelek P , Posmurova M. , Hulejova H. , Senolt L.
Published: May 2020

The aim of this study was to determine the role of the tumor necrosis factor like weak inducer of apoptosis (TWEAK) as a serum biomarker of neuropsychiatric involvement in systemic lupus erythematosus (NPSLE). Levels of TWEAK levels were measured in sera of 92 patients with systemic lupus erythematosus (SLE), including 28 patients with neuropsychiatric lupus, and in 59 healthy controls using ELISA. All SLE patients underwent rheumatological, neurological and psychiatric assessments. We found no significant differences in TWEAK levels, between SLE patients and the healthy controls (p=0.2411). Similarly, no difference was observed between the subgroup of NPSLE and healthy controls (p=0.7658). The mean SLE disease activity (SLEDAI) was 13.25. No correlations between TWEAK levels with disease activity (SLEDAI, r=0.2113, p= 0.2805) or the most common NPSLE manifestations such as headache (r=0.2079), seizures (r=0.1101), cerebrovascular disease (r= 0.2347), cognitive dysfunction (r=0.1597) and anxiety (r=0.1397) were observed. Our data do not support the use of serum TWEAK as a discriminating biomarker for NPSLE. The role of the TWEAK in NPSLE remains to be investigated.
Relationship Between Marital Adjustment and Infant Attachment in Turkish Fathers
Authors: DEMİRBAĞ Birsel , KURTUNCU Meltem , YASAR KIVIK Sümeyye
Published: May 2020

Objective: This study aims to assess the relationship between marital adjustment and paternal-infant attachment.Methods: This descriptive-cross sectional study was conducted between March and April 2017. No sampling was performed, the study wasconducted with 110 fathers who could be accessed between the aforementioned dates and who had babies aged between 0 to 12 monthsold. Questionnaires were asked fathers by researchers.The outcome measurements: Socio-demographic Information Form, Marital AdjustmentTest, and PIAQ. Statistical analysis was performed using SPSS 13.0 program.Results: Fathers’ MAT mean score was found 44.182±5.17, and PIAQ mean score was found 77.935±8.08. There was a positive, weak, butsignificant relationship between MAT and PIAQ (r=0.25; p=0.009). Marital adjustment scores were found to increase with the increase in“patience”, “tolerance”, and “pleasure in interaction” subscale scores. MATsubscales were found to affect each other positively, and this effectwas found to have a significant relationship with paternal-infant attachment level (p<0.05). Good relationship with the spouse was found havestatistically significant relationship with paternal-infant attachment (MWU=165.500; p=0.000).Conclusion: This study revealed that marital adjustment has effects on paternal-infant attachment.
Optimising Potato (Solanum tuberosum L.) Cultivation by Selection of Proper Soils
Authors: Koco Štefan , Vilček Jozef , Torma Stanislav , Michaeli Eva , Solár Vladimír
Published: May 2020

This paper presents an attempt to differentiate the Slovak rural landscape with respect to the possibility of effective potato cultivation and to characterise soil parameters of current potato cultivation areas with the aim to increase the sustainability of the potato production. The selection was based on soil climatic, production and economic parameters. By using the GIS tools and existing databases on soil characteristics in Slovakia, maps of soil suitability categories for potato cultivation were generated. In Slovakia, it was found that 12.3% of farmland is very suitable for potato cultivation and that as much as 43.1% is not suitable. Later, the specified categories were characterised in detail and specified with respect to geographic, soil, climatic, production and economic parameters. Currently, most potato crops are cultivated on Cambisols (27%), Chernozems (20%) and Fluvisols (18%). Loamy soils (content of particles <0.01 mm is 30–45%), soils without gravel (gravel content in the depth 0.0–0.6 m is <10%), deep soils (>0.6 m) and soil situated on plains (slope 0°–3°) are dominant in these regions. We suggest that potato cultivation should be concentrated on the most suitable areas, thereby increasing the economic profitability, improving the ecological stability of the country and supporting the sustainability of the agriculture.
Tigecycline Therapy for Infections Caused by Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae in Critically Ill Patients
Authors: Yu Wen-Liang , Lee Nan-Yao , Wang Jann-Tay , Ko Wen-Chien , Ho Chung-Han , Chuang Yin-Ching
Published: May 2020

We aimed to evaluate tigecycline on the clinical effectiveness in treating complicated skin and soft tissue infections (cSSTI), complicated intra-abdominal infections (cIAI), and pneumonia, caused by extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae, as data are limited. From three medical centers in Taiwan, we retrospectively studied the cSSTI, cIAI, and/or pneumonia caused by ESBL-producing Enterobacteriaceae. Among the 71 patients, including 39 patients infected with Klebsiella pneumoniae, 30 infected with Escherichia coli and others, the clinical success rate of tigecycline-based therapy was 80–90% for pneumonia and cSSTI caused by E. coli and 50–60% for cIAI caused by K. pneumoniae and E. coli. Microbiological and clinical outcome of pneumonia caused by carbapenem-resistant K. pneumoniae was poor. Univariate Cox analysis showed that dyspnea, SOFA score, septic shock, thrombocytopenia, prolonged prothrombin time, and lesser microbiological eradication were significant factors associated with 30-day mortality after the end of therapy. Cox regression proportional hazards model revealed dyspnea and a SOFA score > 8 to be independently associated with time to death. For ESBL producers, tigecycline showed good effects for cSSTI and pneumonia by E. coli, ordinary for cIAI, but ineffective for pneumonia by K. pneumoniae. Dyspnea and a high SOFA score predict a poor outcome.
Redox and Thiols in Archaea
Authors: Rawat Mamta , Maupin-Furlow Julie A.
Published: May 2020

Low molecular weight (LMW) thiols have many functions in bacteria and eukarya, ranging from redox homeostasis to acting as cofactors in numerous reactions, including detoxification of xenobiotic compounds. The LMW thiol, glutathione (GSH), is found in eukaryotes and many species of bacteria. Analogues of GSH include the structurally different LMW thiols: bacillithiol, mycothiol, ergothioneine, and coenzyme A. Many advances have been made in understanding the diverse and multiple functions of GSH and GSH analogues in bacteria but much less is known about distribution and functions of GSH and its analogues in archaea, which constitute the third domain of life, occupying many niches, including those in extreme environments. Archaea are able to use many energy sources and have many unique metabolic reactions and as a result are major contributors to geochemical cycles. As LMW thiols are major players in cells, this review explores the distribution of thiols and their biochemistry in archaea.
Role of Selenoproteins in Redox Regulation of Signaling and the Antioxidant System: A Review
Authors: Zhang Ying , Roh Yeon Jin , Han Seong-Jeong , Park Iha , Lee Hae Min , Ok Yong Sik , Lee Byung Cheon , Lee Seung-Rock
Published: May 2020

Selenium is a vital trace element present as selenocysteine (Sec) in proteins that are, thus, known as selenoproteins. Humans have 25 selenoproteins, most of which are functionally characterized as oxidoreductases, where the Sec residue plays a catalytic role in redox regulation and antioxidant activity. Glutathione peroxidase plays a pivotal role in scavenging and inactivating hydrogen and lipid peroxides, whereas thioredoxin reductase reduces oxidized thioredoxins as well as non-disulfide substrates, such as lipid hydroperoxides and hydrogen peroxide. Selenoprotein R protects the cell against oxidative damage by reducing methionine-R-sulfoxide back to methionine. Selenoprotein O regulates redox homeostasis with catalytic activity of protein AMPylation. Moreover, endoplasmic reticulum (ER) membrane selenoproteins (SelI, K, N, S, and Sel15) are involved in ER membrane stress regulation. Selenoproteins containing the CXXU motif (SelH, M, T, V, and W) are putative oxidoreductases that participate in various cellular processes depending on redox regulation. Herein, we review the recent studies on the role of selenoproteins in redox regulation and their physiological functions in humans, as well as their role in various diseases.
Potential Cytoprotective Activity of Ozone Therapy in SARS-CoV-2/COVID-19
Authors: Martínez-Sánchez Gregorio , Schwartz Adriana , Di Donna Vincenzo
Published: May 2020

(1) Background: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) in China at the end of 2019 has caused a large global outbreak. Systemic ozone therapy (OT) could be potentially useful in the clinical management of several complications secondary to SARS-CoV-2. The rationale and mechanism of action has already been proven clinically in other viral infections and has been shown in research studies to be highly effective at decreasing organ damage mediated by inflammation and oxidative stress. This review summarizes the OT studies that illustrate the possible cytoprotective mechanism of action of ozone and its physiological by-products in target organs affected by SARS-CoV-2. (2) Methods: This review encompasses a total of 74 peer-reviewed original articles. It is mainly focused on ozone as a modulator of the NF-κB/Nrf2 pathways and IL-6/IL-1β expression. (3) Results: In experimental models and the few existent clinical studies, homeostasis of the free radical and antioxidant balance by OT was associated with a modulation of NF-κB/Nrf2 balance and IL-6 and IL-1β expression. These molecular mechanisms support the cytoprotective effects of OT against tissue damage present in many inflammatory diseases, including viral infections. (4) Conclusions: The potential cytoprotective role of OT in the management of organ damage induced by COVID-19 merits further research. Controlled clinical trials are needed.
Multi-Task Learning U-Net for Single-Channel Speech Enhancement and Mask-Based Voice Activity Detection
Authors: Lee Geon Woo , Kim Hong Kook
Published: May 2020

In this paper, a multi-task learning U-shaped neural network (MTU-Net) is proposed and applied to single-channel speech enhancement (SE). The proposed MTU-based SE method estimates an ideal binary mask (IBM) or an ideal ratio mask (IRM) by extending the decoding network of a conventional U-Net to simultaneously model the speech and noise spectra as the target. The effectiveness of the proposed SE method was evaluated under both matched and mismatched noise conditions between training and testing by measuring the perceptual evaluation of speech quality (PESQ) and short-time objective intelligibility (STOI). Consequently, the proposed SE method with IRM achieved a substantial improvement with higher average PESQ scores by 0.17, 0.52, and 0.40 than other state-of-the-art deep-learning-based methods, such as the deep recurrent neural network (DRNN), SE generative adversarial network (SEGAN), and conventional U-Net, respectively. In addition, the STOI scores of the proposed SE method are 0.07, 0.05, and 0.05 higher than those of the DRNN, SEGAN, and U-Net, respectively. Next, voice activity detection (VAD) is also proposed by using the IRM estimated by the proposed MTU-Net-based SE method, which is fundamentally an unsupervised method without any model training. Then, the performance of the proposed VAD method was compared with the performance of supervised learning-based methods using a deep neural network (DNN), a boosted DNN, and a long short-term memory (LSTM) network. Consequently, the proposed VAD methods show a slightly better performance than the three neural network-based methods under mismatched noise conditions.
Design Optimization and Experimental Verification of Permanent Magnet Synchronous Motor Used in Electric Compressors in Electric Vehicles
Authors: Baek Soo-Whang , Lee Sang Wook
Published: May 2020

In this study, a shape design optimization method is proposed to improve the efficiency of a 3 kW permanent magnet synchronous motor (PMSM) used in an electric compressor intended for use in an electric vehicle. The proposed method improves the efficiency performance of the electric compressor by improving the torque characteristics of the initial PMSM model. The dimensions of the rotor were set as the design variables and were chosen to maximize efficiency and reduce cogging torque. During the determination of the design points with conventional Latin hypercube design, the experimental points may be closely related to each other. Therefore, the optimal Latin hypercube design was used to optimally distribute the experimental points evenly and improve the space filling characteristics. The Kriging model was used as an interpolation model to predict the optimal values of the design variables. This allowed the formulation of more accurate prediction models with multiple design variables, complex reactions, or nonlinearities. A genetic algorithm was used to identify the optimal solution for the design variables. It was used to satisfy the objective function and to determine the optimal design variables based on established constraints. The optimal design results obtained based on the proposed shape optimization method were confirmed by finite element analyses. For practical verification, the optimal model of the prototype PMSM of an electric compressor was manufactured, and a 1.5% improvement in its efficiency performance was confirmed based on an experimental dynamometer test.