bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Manganese‐Catalyzed Alkyl‐Heck‐Type Reaction via Oxidative Decarbonylation of Aldehydes.
Authors: Zong Zhenzhen , Wang Wenxiao , Bai Xiaohui , Xi Hui , Li Zhiping
Published: October 2015

An alkyl‐Heck‐type cross‐coupling reaction of primary, secondary, and tertiary aliphatic aldehydes is reported which is catalyzed by MnBr2.
ChemInform Abstract: Dual Catalytic Activity of Palladium Doped with a Rhodium Complex in a One‐Pot, Four Step Process.
Authors: Shapiro Leora , Driess Matthias , Avnir David
Published: October 2015

The H2 pressure is critical for the reaction outcome: lower pressure lowers the conversion, higher pressure favours ethylbenzene as final product.
ChemInform Abstract: Copper‐Catalyzed N—H Insertion and Oxidative Aromatization Cascade: Facile Synthesis of 2‐Arylaminophenols.
Authors: Ding Dong , Lv Xiaobing , Li Jian , Xu Guangyang , Ma Bing , Sun Jiangtao
Published: October 2015

A series of 2‐arylaminophenols is efficiently obtained by a novel reaction of various substituted aniline derivatives with 6‐diazo‐2‐cyclohexenones using molecular oxygen as green oxidant.
ChemInform Abstract: Synthesis of Aldehydes from Tertiary Amides Using a Novel Modified Red‐Al Reducing Agent.
Authors: Shin Won Kyu , Jang Hee Mang , Choi Byung Hoon , Yoo Jaeduk , An Duk Keun
Published: October 2015

The protocol is the first systematic and general study of the partial reduction of tertiary amides (I) to aldehydes (II) using a modified Red‐Al reducing agent.
ChemInform Abstract: A Green Synthesis of Highly Substituted 1,5‐Diketones.
Authors: Liu Lei , Feng Suliu , Li Chunbao
Published: October 2015

In comparison to the organic‐mediated reaction, the aqueous alternative offers several advantages including simple workup, high yields and diastereoselectivities.
ChemInform Abstract: Ni‐Catalyzed Alkenylation of Ketone Enolates under Mild Conditions: Catalyst Identification and Optimization.
Authors: Grigalunas Michael , Ankner Tobias , Norrby Per‐Ola , Wiest Olaf , Helquist Paul
Published: October 2015

Following a scalable reaction procedure, cyclic and acyclic alkyl substituted as well as aryl substituted ketone enolates are efficiently alkenylated with 1‐ or 2‐mono or 2,2‐disubstituted alkenyl bromides.
ChemInform Abstract: Base‐Catalyzed N—N Bond Cleavage of Hydrazones: Synthesis of α‐Amino Ketones.
Authors: Tang Hai‐Tao , Zhou Yun‐Bing , Zhu Yu , Sun Hong‐Chao , Lin Min , Zhan Zhuang‐Ping
Published: October 2015

α‐Amino ketones are synthesized starting from aldehydes, hydrazines, and α‐haloketones via a novel, efficient, Cs2CO3‐promoted cascade condensation/nucleophilic substitution/ N‐N bond cleavage sequence in one‐pot.
ChemInform Abstract: Metal‐Free Direct Aryltrifluoromethylation of Allylic Alcohols with Langlois′ Reagent Through Concomitant 1,2‐Aryl Migration.
Authors: Huang Hong‐Li , Yan Hang , Gao Guo‐Lin , Yang Chao , Xia Wujiong
Published: October 2015

A new metal‐free, oxidative synthetic strategy for difunctionalization of C=C double bonds of allylic alcohols using CF3SO2Na as the CF3 source and (NH4)2S2O8 as the oxidant is presented.
ChemInform Abstract: Palladium‐Catalyzed Synthesis of α‐Diimines from Triarylbismuthines and Isocyanides.
Authors: Kobiki Yohsuke , Kawaguchi Shin‐ichi , Ogawa Akiya
Published: October 2015

A novel synthetic route to α‐diimines is developed.
ChemInform Abstract: A Palladium‐Catalyzed Arylation of N‐Acyl‐N,O‐acetals with Arylboronic Reagents: Synthesis of Diarylmethylamines Protected by Easily Removable Acyl Group.
Authors: Chen Qian , Liu Chao , Guo Fang , Li Liang
Published: October 2015

Attempts upon an asymmetric version of the reaction procedure based on the use of chiral ligands provides the products with low enantiomeric excess only.
ChemInform Abstract: Copper‐Catalyzed γ‐Sulfonylation of α,β‐Unsaturated Carbonyl Compounds by Means of Silyl Dienol Ethers.
Authors: Liu Xiaoguang , Chen Xiaohong , Mohr Justin T.
Published: October 2015

For the first time a regioselective protocol for introduction of sulfonyl groups at the γ‐carbon of enone systems is described.
ChemInform Abstract: Catalytic Oxidative Carbonylation of Amino Moieties to Ureas, Oxamides, 2‐Oxazolidinones, and Benzoxazolones.
Authors: Mancuso Raffaella , Raut Dnyaneshwar S. , Della Ca' Nicola , Fini Francesco , Carfagna Carla , Gabriele Bartolo
Published: October 2015

Conditions for the efficient carbonylation of anilines, β‐amino alcohols, and 2‐aminophenols are elaborated which provide 1,3‐diaryl ureas, 2‐oxazolidinones, or benzoxazolones, respectively.
ChemInform Abstract: Synthesis of 2‐X‐, 3‐X‐4,4′‐Dicyanobiphenyls (X: CH3, OCH3, F) by Cross‐Coupling of the Terephthalonitrile Dianion with Substituted Benzonitriles.
Authors: Peshkov Roman Yu. , Panteleeva Elena V. , Shchegoleva Lyudmila N. , Bagryanskaya Irina Yu. , Rybalova Tatyana V. , Vasilieva Nadezhda V. , Shteingarts Vitalij D.
Published: October 2015

2‐ and 3‐Substituted 4,4′‐dicyanobiphenyls are obtained by a concise and noncatalytic method using the in situ generated terephthalonitrile dianion as para‐cyanophenylation reagent.
ChemInform Abstract: Synthesis of Biaryls by Decarboxylative Hiyama Coupling.
Authors: Katayev Dmitry , Exner Benjamin , Goossen Lukas J.
Published: October 2015

This is the first protocol using nontoxic but rather unreactive organosilanes as partner in the decarboxylative Hiyama coupling giving the biaryls in high yields while keeping halo functions intact.
ChemInform Abstract: Gold‐Catalyzed 6‐Exo‐Dig Cycloisomerization: A Versatile Approach to Functionalized Phenanthrenes.
Authors: Shu Chao , Li Long , Chen Cheng‐Bin , Shen Hong‐Cheng , Ye Long‐Wu
Published: October 2015

Various functionalized phenanthrenes are synthesized with good functional group tolerance by a general and practical method starting from readily available o‐propargyl biaryls under mild reaction conditions.
ChemInform Abstract: CuX2‐Mediated Oxybromination/Aminochlorination of Unsaturated Amides: Synthesis of Iminolactones and Lactams.
Authors: Zhang Zhi‐Qiang , Liu Feng
Published: October 2015

A range of variously substituted γ,δ‐unsaturated amides are transformed via CuBr2‐mediated oxybromination to iminolactones.
ChemInform Abstract: An Umpolung Approach to Alkene Carboamination: Palladium Catalyzed 1,2‐Amino‐Acylation, ‐Carboxylation, ‐Arylation, ‐Vinylation, and ‐Alkynylation.
Authors: Faulkner Adele , Scott James S. , Bower John F.
Published: October 2015

A diverse range of alkene containing oxime esters is transformed with multiple nucleophiles, including tetraaryl borates, (het)aryl, alkenyl, and alkynyl boronates as well as alcohols, with or without concomitant carbonylation.
ChemInform Abstract: Palladium‐Catalyzed Alkene Carboamination Reactions of Electron‐Poor Nitrogen Nucleophiles.
Authors: Peterson Luke J. , Wolfe John P.
Published: October 2015

Substituted pyrrolidines are obtained by coupling of pent‐4‐enylamine derivatives bearing N‐tosyl or N‐trifluoroacetyl moieties with various aryl triflates involving an anti‐aminopalladation of the alkene.
ChemInform Abstract: Diastereoselective Construction of 3‐Aminooxindoles with Adjacent Stereocenters: Stereocontrolled Addition of γ‐Substituted Allylindiums to Isatin Ketimines.
Authors: Aslam Nayyar Ahmad , Babu Srinivasarao Arulananda , Rani Soniya , Mahajan Shivam , Solanki Jagmohan , Yasuda Makoto , Baba Akio
Published: October 2015

An indium‐mediated Barbier‐type C—C bond formation is achieved by addition of γ‐substituted allylic reagents to the C=N bond of isatin ketimines, resulting in the formation of 3‐allyl‐3‐aminooxindoles with a high degree of stereocontrol and without hydrolysis of the isatin ketimines.
ChemInform Abstract: Metal‐Free Direct Cyanoisopropylation/Arylation of N‐Arylacrylamides or N‐Alkyl‐N‐(arylsulfonyl)acrylamides with AIBN: A Simple and Mild Approach to Cyano‐Containing Oxindoles.
Authors: Zhang Mingzhong , Sheng Wenbing , Ji Pengyi , Liu Yufeng , Guo Cancheng
Published: October 2015

A simple and metal‐free direct cyanoisopropylation/arylation of N‐arylacrylamides and N‐alkyl‐N‐(arylsulfonyl)acrylamides with AIBN is developed using MeNO2 as both solvent and oxidant.
ChemInform Abstract: Organocatalytic Asymmetric Reaction of Indol‐2‐yl Carbinols with Enamides: Synthesis of Chiral 2‐Indole‐Substituted 1,1‐Diarylalkanes.
Authors: Liu Chao‐You , Han Fu‐She
Published: October 2015

The title reaction is applicable to a wide variety of indol‐2‐yl carbinols and various enamides.
ChemInform Abstract: Diastereoselective Oxidative C—N/C—O and C—N/C—N Bond Formation Tandems Initiated by Visible Light: Synthesis of Fused N‐Arylindolines.
Authors: Morris Scott A. , Nguyen Theresa H. , Zheng Nan
Published: October 2015

C‐2 and C‐3 fused indolines with a tetrasubstituted carbon stereocenter are obtained with diastereoselectivities higher than 99:1 from both oxygen or nitrogen nucleophiles.
ChemInform Abstract: One‐Pot Preparation of 2,5‐Disubstituted and 2,4,5‐Trisubstituted Oxazoles from Aromatic Ketones with Molecular Iodine, Oxone, and Trifluoromethanesulfonic Acid in Nitriles.
Authors: Imai Sho , Kikui Hiroki , Moriyama Katsuhiko , Togo Hideo
Published: October 2015

The reaction tolerates variously substituted arylmethyl ketones as well as hetarylmethyl ketones and is performed using alkyl nitriles, benzonitrile as well as succinonitrile as the reaction partner.
ChemInform Abstract: Copper(II)‐Catalyzed Oxidative [3 + 2] Cycloaddition Reactions of Secondary Amines with α‐Diazo Compounds: A Facile and Efficient Synthesis of 1,2,3‐Triazoles.
Authors: Li Yi‐Jin , Li Xue , Zhang Shao‐Xiao , Zhao Yu‐Long , Liu Qun
Published: October 2015

The title reaction of secondary amines with α‐diazo compounds proceeds via a cross‐dehydrogenative coupling process involving a sequential aerobic oxidation/[3+2] cycloaddition/oxidative aromatization procedure and provides an efficient method for the construction of 1,2,3‐triazoles in a single step in an atom‐economic manner from readily available starting materials under very mild conditions.
ChemInform Abstract: Silica‐Supported Cationic Gold(I) Complexes as Heterogeneous Catalysts for Regio‐ and Enantioselective Lactonization Reactions.
Authors: Shu Xing‐Zhong , Nguyen Son C. , He Ying , Oba Fadekemi , Zhang Qiao , Canlas Christian , Somorjai Gabor A. , Alivisatos A. Paul , Toste F. Dean
Published: October 2015

The utility of the newly prepared catalysts is demonstrated by their application in the transformation of various allenoic acids to five‐ or six‐membered ring lactones.
ChemInform Abstract: N‐Heterocyclic Carbene‐Catalyzed Enantioselective Annulation of Indolin‐3‐ones with Bromoenals
Authors: Ni Qijian , Song Xiaoxiao , Raabe Gerhard , Enders Dieter
Published: October 2015

[affording a variety of 3,4‐dihydropyrano[3,2‐b]indol‐2(5H)‐ones].
ChemInform Abstract: KOtBu‐Mediated Annulation of Acetonitrile with Aldehyde: Synthesis of Substituted Dihydropyridin‐2(1H)‐ones, Pyridin‐2(1H)‐ones, and Thiopyridin‐2(1H)‐ones.
Authors: Yadav Abhimanyu , Verma Ajay , Patel Saket , Kumar Amit , Rathore Vandana , Meenakshi Meenakshi , Kumar Shailesh , Kumar Sangit
Published: October 2015

Starting from diversely substituted aryl, heteroaryl, and alkyl aldehydes, the title reaction provides substituted dihydropyridin‐2(1H)‐ones in moderate yields.
ChemInform Abstract: Site‐Selective Synthesis of Arylated Pyridines by Suzuki—Miyaura Reactions of 2,3,5,6‐Tetrachloropyridine.
Authors: Reimann Sebastian , Ehlers Peter , Parpart Silvio , Surkus Annette , Spannenberg Anke , Langer Peter
Published: October 2015

The site selective mono‐, di‐ and triarylation of 2,3,5,6‐tetrachloropyridine is described.
ChemInform Abstract: Iron Oxide‐Silver Magnetic Nanoparticles as Simple Heterogeneous Catalysts for the Direct Inter/Intramolecular Nucleophilic Substitution of π‐Activated Alcohols with Electron‐Deficient Amines.
Authors: Xu Xingzhu , Wu Haibo , Li Zhengyi , Sun Xiaoqiang , Wang Zhiming
Published: October 2015

The method provides a facile and efficient access to allylic amines and 1,2‐dihydroquinolines equipped with diverse substituents.
ChemInform Abstract: Visible‐Light Induced Trifluoromethylation of N‐Arylcinnamamides for the Synthesis of CF3‐Containing 3,4‐Disubstituted Dihydroquinolinones and 1‐Azaspiro[4.5]decanes.
Authors: Gao Fei , Yang Chao , Gao Guo‐Lin , Zheng Lewei , Xia Wujiong
Published: October 2015

The blue LED induced trifluoromethylation of α,β‐unsaturated N‐arylamides with Togni′s reagent gives access to a variety of CF3‐containing dihydroquinolinones.
ChemInform Abstract: A Chiral Phosphoric Acid Catalyst for Asymmetric Construction of 1,3‐Dioxanes.
Authors: Matsumoto Akira , Asano Keisuke , Matsubara Seijiro
Published: October 2015

(E)‐5‐Hydroxy‐1‐arylpent‐2‐en‐1‐ones as well as the corresponding alkyl and alkenyl derivatives are transformed with hexanal according to the title reaction, thus furnishing 1,3‐dioxanes in high yields and with high enantiomeric excess.
ChemInform Abstract: CAN Catalyzed Synthesis of 1H‐Indazolotriones.
Authors: Revathy Krishnan , Lalitha Appaswami
Published: October 2015

A facile multicomponent synthesis of biologically active indazolophthalazinetrione derivatives (IV) is given.
ChemInform Abstract: Study of the Chemoselectivity of Multicomponent Heterocyclizations Involving 3‐Amino‐1,2,4‐triazole and Pyruvic Acids as Key Reagents, and Biological Activity of the Reaction Products.
Authors: Chebanov Valentin A. , et al.
Published: October 2015

Different reaction conditions for controlling the selectivity of multicomponent reactions involving 3‐amino‐1,2,4‐triazole and pyruvic acids are investigated leading to products of several structural classes.
ChemInform Abstract: Copper‐Catalyzed Intramolecular C—C Bond Cleavage to Construct 2‐Substituted Quinazolinones.
Authors: Hu Ben‐Quan , Wang Li‐Xia , Yang Luo , Xiang Jun‐Feng , Tang Ya‐Lin
Published: October 2015

The title quinazolinones are efficiently obtained by selective intramolecular cleavage of the C—C bond at position C‐2 of 2,2‐disubstituted tetrahydroquinazolinones using air as oxidant under basic reaction conditions.
ChemInform Abstract: A Facile and Efficient Synthesis of 4H‐1,3‐Benzoxazine‐4‐one with Electron‐Withdrawing Group Derivatives.
Authors: Li Peng , Zhang Xinwei , Wu Yongqi , Cheng Maosheng , Zhang Dongfeng , Li Gang , Lin Ziyun , Zhang Xiang , Huang Haihong
Published: October 2015

Electron‐withdrawing substituents on the phenyl ring facilitate the base mediated heterocyclization of o‐halobenzoylureas to afford benzoxazinones.
ChemInform Abstract: Annuloselectivity in Reactions of Diacyl Dichlorides and Imines: Combined Experimental and Theoretical Studies.
Authors: Li Xinyao , Jin Xin , Xu Jiaxi
Published: October 2015

The selectivity between [2+2] and cascade annulation of diacyl chlorides and imines in the presence of Et3N leading to bis‐β‐lactams and/or 2,3‐dihydro‐1,3‐oxazin‐4‐ones is studied.
ChemInform Abstract: A Three‐Component Reaction for Rapid Access to Underexplored 1,3‐Thiazine‐2‐thiones.
Authors: Kroeger Denis , Brockmeyer Fabian , Kahrs Christoph
Published: October 2015

Starting from 2,3‐diaryl‐3‐chlorovinyl aldehydes, carbon disulfide and various primary alkyl amines a straightforward access to the title products is elaborated which are further transformed to annulated heterocycles.
ChemInform Abstract: Enantioselective Alkynylation of Benzo[e][1,2,3]‐oxathiazine 2,2‐Dioxides Catalyzed by (R)‐VAPOL‐Zn Complexes: Synthesis of Chiral Propargylic Cyclic Sulfamidates.
Authors: De Munck Lode , Monleon Alicia , Vila Carlos , Munoz M. Carmen , Pedro Jose R.
Published: October 2015

The reaction tolerates aryl, hetaryl, and alkyl substituted acetylenes, and the corresponding products are isolated in moderate to high yields and with moderate to high enantiomeric excess.
ChemInform Abstract: Silver Triflate Catalyzed Cyclopropyl Carbinol Rearrangement for Benzo[b]oxepine and 2H‐Chromene Synthesis.
Authors: Chan Philip Wai Hong , Teo Wan Teng , Koh Shaun Wei Yong , Lee Bo Ra , Ayers Benjamin James , Ma Dik‐Lung , Leung Chung‐Hang
Published: October 2015

A wide range of functionalized oxygen heterocycles are obtained by a general method starting from 2‐[cyclopropyl(hydroxy)methyl]phenols.
ChemInform Abstract: A Four‐Component Reaction for the Synthesis of Dioxadiazaborocines.
Authors: Flagstad Thomas , Petersen Mette T. , Nielsen Thomas E.
Published: October 2015

The condensation of functionalized hydrazines (I) with boronic acids gives dioxadiazaborocines (III).
ChemInform Abstract: Ni(II)‐Catalyzed Dehydrative Alkynylation of Unactivated (Hetero)aryl C—H Bonds Using Oxygen: A User‐Friendly Approach.
Authors: Liu Yan‐Hua , Liu Yue‐Jin , Yan Sheng‐Yi , Shi Bing‐Feng
Published: October 2015

N‐(2‐pyridinylisopropyl)amide substituted aromatics and hetaromatics are alkynylated with silyl group‐containing alkynes.
ChemInform Abstract: Simplified Preparation of Trialkylvinylsilanes via the Silyl‐Heck Reaction Utilizing a Second Generation Catalyst.
Authors: McAtee Jesse R. , Krause Sarah B. , Watson Donald A.
Published: October 2015

Vinylsilanes are efficiently obtained from styrene derivatives utilizing the new ligand, SGL, in combination with the readily available palladium pre‐catalyst, Pd2(dba)3.
ChemInform Abstract: Sesquiterpene Dimers Esterified with Diverse Small Organic Acids from the Seeds of Sarcandra glabra.
Authors: Wang Peng , Luo Jun , Zhang Yang‐Mei , Kong Ling‐Yi
Published: October 2015

The isolation and structure elucidation of sarglabolides A (I), B‐G, H (IIIa), I (II), J (IIIb) and K (IIIc) is described.
ChemInform Abstract: Xylapyrrosides A and B, Two Rare Sugar‐Morpholine Spiroketal Pyrrole‐Derived Alkaloids from Xylaria nigripes: Isolation, Complete Structure Elucidation, and Total Syntheses.
Authors: Xiong Juan , et al.
Published: October 2015

The moderate antioxidant effects of (I) and (II) are evaluated.
ChemInform Abstract: First Total Synthesis of (6S,1′S,2′S)‐Hydroxypestalotin.
Authors: Mallula Venkata Satyanarayana , Srinivas Batthula , Radha Krishna Palakodety
Published: October 2015

The total synthesis of the title compound (I) is realized in eleven steps with an overall yield of 20%.
ChemInform Abstract: Solution‐Phase Synthesis of Cesium Lead Halide Perovskite Nanowires.
Authors: Zhang Dandan , Eaton Samuel W. , Yu Yi , Dou Letian , Yang Peidong
Published: October 2015

CsPbX3 (X: Br, Cl, I) nanowires (NWs) are prepared by a catalyst‐free, solution‐phase reaction of Cs oleate and PbX2 in presence of oleic acid and oleylamine in octadecene (standard Schlenk technique, 150‐250 °C, 1 h).
ChemInform Abstract: Iron Triad (Fe, Co, Ni) Nanomaterials: Structural Design, Functionalization and Their Applications
Authors: Zhou Wei , Guo Lin
Published: October 2015

Review: 50 refs.
ChemInform Abstract: Nanostructured Electrocatalysts for All‐Vanadium Redox Flow Batteries
Authors: Park Minjoon , Ryu Jaechan , Cho Jaephil
Published: October 2015

Review: 90 refs.
ChemInform Abstract: A Review of Manganese‐Based Molecular Magnets and Supramolecular Architectures from Phenolic Oximes
Authors: Yang Chen‐I. , Zhang Zu‐Zhen , Lin Sheng‐Bo
Published: October 2015

Review: 94 refs.
ChemInform Abstract: Multifunctional Metal—Organic Frameworks: From Academia to Industrial Applications
Authors: Silva Patricia , Vilela Sergio M. F. , Tome Joao P. C. , Almeida Paz Filipe A.
Published: October 2015

Review: functional MOF engineering properties, transposition of the synthesis from the laboratory to the industry and usage in society; 254 refs.
ChemInform Abstract: From Self‐Sorted Coordination Libraries to Networking Nanoswitches for Catalysis
Authors: Schmittel Michael
Published: October 2015

Review: [65 refs.
ChemInform Abstract: Preparation of Stable Metal‐Organic Frameworks for Potential Applications
Authors: Yuan Shuai , Liu Tian‐Fu , Feng Dawei , Zhou Hong‐Cai
Published: October 2015

Review: 6 refs.
ChemInform Abstract: Handbook of Metathesis
Authors: Grubbs Robert H. , Wenzel Anna G. , O'Leary Daniel J. , Khosravi Ezat
Published: October 2015

Review: new edition of the handbook containing 80% new content compared to the first edition with focus on new ligands, diastereoselective metathesis, alkyne metathesis, industrial applications and self‐healing polymers
ChemInform Abstract: The Link that Lasts: A New Frontier in Supramolecular Block Copolymer Design
Authors: Barner Leonie , Barner‐Kowollik Christopher
Published: October 2015

Review: 11 refs.
ChemInform Abstract: Visible‐Light‐Activated Molecular Switches
Authors: Bleger David , Hecht Stefan
Published: October 2015

Review: [conceptual strategies for the design of photochromic compounds that can be toggled between their two switching states by employing only low‐energy visible (or near‐infrared) light; 89 refs.
ChemInform Abstract: Viedma Ripening: A Reliable Crystallization Method to Reach Single Chirality
Authors: Soeguetoglu Leyla‐Cann , Steendam Rene R. E. , Meekes Hugo , Vlieg Elias , Rutjes Floris P. J. T.
Published: October 2015

Review: 50 refs.
ChemInform Abstract: Metal—Organic Frameworks: Versatile Heterogeneous Catalysts for Efficient Catalytic Organic Transformations
Authors: Chughtai Adeel H. , Ahmad Nazir , Younus Hussein A. , Laypkov A. , Verpoort Francis
Published: October 2015

Review: 315 refs.
ChemInform Abstract: Hexaazatriphenylene (HAT) Derivatives: From Synthesis to Molecular Design, Self‐Organization and Device Applications
Authors: Segura Jose L. , Juarez Rafael , Ramos Mar , Seoane Carlos
Published: October 2015

Review: 236 refs.
ChemInform Abstract: Carbon‐Centered Radical Addition to C=X Bonds for C—X Bond Formation
Authors: Liu Dong , Liu Chao , Lei Aiwen
Published: October 2015

Review: [56 refs.
ChemInform Abstract: Asymmetric Epoxidation Using Hydrogen Peroxide as Oxidant
Authors: Wang Chuan , Yamamoto Hisashi
Published: October 2015

Review: [51 refs.
ChemInform Abstract: Ionic Liquids with Weakly Coordinating [MIII(ORF)4]‐ Anions
Authors: Rupp Alexander B. A. , Krossing Ingo
Published: October 2015

Review: 59 refs.
ChemInform Abstract: High‐Generation Organometallic Rotaxane Dendrimer
Authors: Chen Chuanfeng
Published: October 2015

Review: 2 refs.
ChemInform Abstract: Lithiations and Grignard Reactions on Pyrimidine and Quinazoline
Authors: Kolarovic Andrej
Published: October 2015

Review: 117 refs.
ChemInform Abstract: Recent Advances of Modern Protocol for C—C Bonds ‐ the Suzuki Cross‐Coupling
Authors: Soloducho Jadwiga , Olech Kamila , Swist Agnieszka , Zajac Dorota , Cabaj Joanna
Published: October 2015

Review: 85 refs.
ChemInform Abstract: Asymmetric Organocatalytic Reactions under Ball Milling
Authors: Machuca Elizabeth , Juaristi Eusebio
Published: October 2015

Review: 147 refs.
ChemInform Abstract: Enantioselective Catalytic Reactions with N‐Acyliden Penta‐Atomic Aza‐Heterocycles. Heterocycles as Masked Bricks To Build Chiral Scaffolds
Authors: Desimoni Giovanni , Faita Giuseppe , Quadrelli Paolo
Published: October 2015

Review: 106 refs.
ChemInform Abstract: Copper Nanoparticles in Click Chemistry
Authors: Alonso Francisco , Moglie Yanina , Radivoy Gabriel
Published: October 2015

Review: 77 refs.
ChemInform Abstract: Metalloisoporphyrins: from Synthesis to Applications
Authors: Bhuyan Jagannath
Published: October 2015

Review: 100 refs.
ChemInform Abstract: Macrocycles Embedding Phenothiazine or Similar Nitrogen and/or Sulfur Containing Heterocycles
Authors: Rednic Monica Irina , Hadade Niculina D. , Bogdan Elena , Grosu Ion
Published: October 2015

Review: synthesis, structural analalysis and selected applications as host molecules, NA intercalating agents or enzyme inhibitors; 101 refs.
ChemInform Abstract: The Phenomenon of Negative Magnetization and Its Implications
Authors: Kumar Amit , Yusuf S. M.
Published: October 2015

Review: 257 refs.
ChemInform Abstract: DNA Aptamer Based Nanodrugs: Molecular Engineering for Efficiency
Authors: Liu Qiaoling , et al.
Published: October 2015

Review: [50 refs.
ChemInform Abstract: Emerging Trends in Enzyme Inhibition by Multivalent Nanoconstructs
Authors: Kanfar Nasreddine , Bartolami Eline , Zelli Renaud , Marra Alberto , Winum Jean‐Yves , Ulrich Sebastien , Dumy Pascal
Published: October 2015

Review: 87 refs.
ChemInform Abstract: Organometallic Water Splitting ‐ from Coordination Chemistry to Catalysis
Authors: Klahn Marcus , Beweries Torsten
Published: October 2015

Review: 85 refs.
ChemInform Abstract: Light: A Very Peculiar Reactant and Product
Authors: Balzani Vincenzo , Bergamini Giacomo , Ceroni Paola
Published: October 2015

Review: 117 refs.
ChemInform Abstract: Nanostructured Conductive Polymers for Advanced Energy Storage
Authors: Shi Ye , Peng Lele , Ding Yu , Zhao Yu , Yu Guihua
Published: October 2015

Review: 54 refs.
ChemInform Abstract: Evaluation on the Potential with Channel‐Type and Cage‐Type Metal‐Organic Frameworks as Absorbents in Solid‐Phase Microextraction
Authors: Huang Hsi‐Ya , Lirio Stephen , Shih Yung‐Han , Lin Chia‐Her
Published: October 2015

Review: 3 refs.
ChemInform Abstract: Anion Recognition and Sensing by Transition‐Metal Complexes with Polarized N‐H Recognition Motifs
Authors: Chang Kai‐Chi , Sun Shih‐Sheng , Odago Maurice O. , Lees Alistair J.
Published: October 2015

Review: 113 refs.
ChemInform Abstract: Unraveling the Mechanism of Chemical Reactions Through Thermodynamic Analyses: A Short Review
Authors: Meunier F. C. , Scalbert J. , Thibault‐Starzyk F.
Published: October 2015

Review: 44 refs.
ChemInform Abstract: Multidimensional Electronic Spectroscopy of Photochemical Reactions
Authors: Nuernberger Patrick , Ruetzel Stefan , Brixner Tobias
Published: October 2015

Review: 242 refs.
ChemInform Abstract: NMR Studies of Dynamic Biomolecular Conformational Ensembles
Authors: Torchia Dennis A.
Published: October 2015

Review: 173 refs.
ChemInform Abstract: Elucidating Organic Reaction Mechanisms Using Photo‐CIDNP Spectroscopy
Authors: Goez Martin
Published: October 2015

Review: 78 refs.
Comparison of the clinicopathologic features and prognosis of bilateral versus unilateral multifocal papillary thyroid cancer: An updated study with more than 2000 consecutive patients
Authors: Wang Weibin , Su Xingyun , He Kuifeng , Wang Yanli , Wang Haiyong , Wang Haohao , Zhao Yinu , Zhao Wenhe , Zarnegar Rasa , Fahey Thomas J. , Teng Xiaodong , Teng Lisong
Published: October 2015

BACKGROUND

Bilaterality is common in papillary thyroid cancer (PTC), but its clinical and prognostic implications are still controversial, and it remains unclear whether its behavior is more aggressive than multifocality.

METHODS

The clinicopathologic features of 2211 consecutive patients with PTC who underwent surgical treatment at the authors’ institute between 1997 and 2011 were reviewed. Among these surgical patients, 425 (19.2%) had bilateral PTCs, and 1786 had unilateral PTCs. The patients who had unilateral PTCs were subdivided into a group with unilateral‐multifocal PTCs (210 patients) and a group with solitary PTCs (1576 patients). The 10‐year disease‐free survival (DFS) rates were calculated to compare the prognosis between groups. B‐Raf proto‐oncogene, serine/threonine kinase (BRAF) mutation status was examined by direct DNA sequencing.

RESULTS

Patients who had bilateral PTCs were likely to have larger tumors, higher rates of extrathyroid extension and lymph node metastasis, and more advanced tumor stage than those who had unilateral‐multifocal PTCs. Multivariate analysis identified only lymph node metastasis as an independent risk factor for PTC recurrence (P < .001). The 10‐year DFS rate for patients with bilateral PTCs was much lower than that for those with unilateral‐multifocal and solitary PTCs (78.8% vs 85.7% and 89.3%, respectively; P = .005). It is noteworthy that patients who had bilateral PTCs with lymph node metastasis had the worst prognosis in terms of DFS. Incidence of the BRAF V600E mutation (valine to glutamic acid mutation at position 600) was higher in the bilateral PTC group than that in the unilateral and unilateral‐multifocal PTC groups.

CONCLUSIONS

The current results provide initial evidence that bilateral PTCs are more aggressive than unilateral‐multifocal PTCs, and patients who have bilateral disease have more advanced stage and shorter DFS. The poorer outcome of patients with bilateral PTCs may be caused in part by their high incidence of lymph node metastasis. Cancer 2016;122:198–206. © 2015 American Cancer Society.
Another look at the informed consent process: The document and the conversation
Authors: Wall Louisa K. , Pentz Rebecca D.
Published: October 2015

In their study, Koyfman et al report an innovative research strategy analyzing the simplicity of both the consent document and conversation. In this editorial, the authors offer modifications to the 2 recommendations made by Koyfman et al.
Inhibitors of bacterial protease enzymes for periodontal therapy
Authors: Hosn Kalid N. , Jefferson Mary Margaret , Leding Carlton , Shokouh‐Amiri Solomon , Thomas Edwin L.
Published: October 2015

Locally applied therapeutic agents have become established in the treatment of periodontal disease. Inhibition of human metalloproteases by metal‐chelating antibiotics contributes to the utility of local therapy. Adding inhibitors of bacterial proteases might extend and improve local therapy. The periodontal pathogen Porphyromonas gingivalis (Pg) produces two extracellular cysteine proteases (gingipains Rgp and Kgp) that are virulence factors and contribute to destruction of oral tissues. Our aims were to compare efficacy of protease inhibitors against gingipains and evaluate bactericidal activity of the inhibitors. Protease activity was measured in fluorescent assays with specific Rgp and Kgp substrates. Bacterial viability was measured with BacLight™ (Invitrogen, Inc., Carlsbad, CA) reagents. Pairs of inhibitors of Rgp and Kgp, respectively, were leupeptin and cathepsin B inhibitor II, KYT‐1 and KYT‐36, and PPACK and Z‐FK‐ck. The cysteine‐protease inhibitor E64 was also tested. Rgp activity was higher than Kgp activity, and activity was higher in Pg 33277 and 49417 cell suspensions than in media. Concentrations required for 50% inhibition of Rgp in cell suspensions were 2 × 10−9, 2 × 10−9, 2 × 10−8, and 5 × 10−5 M for KYT‐1, PPACK, leupeptin, and E64, respectively. Concentrations required for 50% Kgp inhibition were 5 × 10−10, 1 × 10−9, and 5 × 10−8 M for Z‐FK‐ck, KYT‐36, and cathepsin B inhibitor II. E64 did not inhibit Kgp. Inhibition of Rgp could be accounted for by competition for binding between the arginine residue of the substrate and the guanidinobutane portion of E64. PPACK was the least selective, with a 10‐fold difference in concentrations that inhibited Rgp and Kgp. KYT‐1 and Z‐FK‐ck inhibited both Rgp and Kgp, but inhibitory concentrations differed by 10,000‐fold. At up to 1 × 10−4 M, only Z‐FK‐ck was bactericidal. KYT‐1 and KYT‐36 were remarkably effective even when used in cell suspensions in which bacterial proteins could bind inhibitors or compete for binding to gingipains. These inhibitors might prove useful as an addition to locally applied therapeutic agents.
Antibodies produced in vitro in the detection of periodontal bacteria by using surface plasmon resonance analysis
Authors: Nakka Sravya Sowdamini , Lönn Johanna , Starkhammar Johansson Carin , Bengtsson Torbjörn , Nayeri Fariba
Published: October 2015

Porphyromonas gingivalis (P. gingivalis) is a major etiological agent associated with periodontitis. This study aims to develop antibodies to P. gingivalis in vitro for real‐time detection of bacteria in clinical samples. Lymphocytes were isolated from whole blood of patient treated for periodontitis and were stimulated with P. gingivalis ATCC 33277. B‐cell maturation to long‐living antibody secreting‐plasma cells was studied using flow cytometry and immunofluorescence staining. The antibodies developed in vitro were immobilized onto a CM‐5 sensor chip of a biosensor to detect the presence of P. gingivalis in the gingival crevicular fluid of patients with periodontitis compared to periodontally healthy controls (n = 30). Surface plasmon resonance (SPR) analysis was performed to evaluate specific interactions of bacteria in samples with the immobilized antibodies. The results of SPR analysis were compared to the detection of P. gingivalis in the samples using DNA–DNA checkerboard hybridization technique. A clear and distinct change in lymphocyte morphology upon stimulation with P. gingivalis was observed. Anti‐P. gingivalis antibodies secreted by CD38+ plasma cells showed the presence of all the four IgG subclasses. The results of DNA–DNA checkerboard analysis were in agreement with that of SPR analysis for the detection of P. gingivalis in patient samples. Furthermore, incubation with anti‐P. gingivalis attenuated the bacterial response in SPR. The in vitro method for antibody production developed during this study could be used for an efficient real‐time detection of periodontitis, and the attenuating effects of in vitro antibodies suggest their role in passive immunization to prevent periodontitis and their associated risk factors.
Variable source contributions to river bed sediments across three size fractions
Authors: Haddadchi Arman , Olley Jon , Pietsch Timothy
Published: October 2015

Sediment tracing using geochemical properties is an efficient way to identify the spatial sources of transported sediments delivered to waterways. Here, the contribution of soil sources to river bed sediments has been quantified in Emu Creek, a headwater catchment in south eastern Queensland, Australia. Soil samples were collected from the eight major rock types present in the catchment and were related to river bed sediments collected from eight sites along the main channel. Geochemistry, as characterized by 39 elemental concentrations, was measured using inductively coupled plasma mass spectrometry and inductively coupled plasma optical emission spectrometry. Three particle size fractions were examined, <10, 10–63 and 63–212 µm, with the three resultant mixing models showing divergent results. We conclude that the results of sediment mixing models based on the analysis of one grain size should not be assumed to apply across the entire particle size range of transported sediment, emphasizing the need to match the size fraction used in tracing studies to that size fraction of interest in downstream sinks. Furthermore, we present results highlighting the control transport distance plays in source dominance, with this particularly evident in the coarser fraction, where local sources dominate over more distant sources. Copyright © 2015 John Wiley & Sons, Ltd.
CD73 regulates vascular smooth muscle cell functions and facilitates atherosclerotic plaque formation
Authors: Yang Jiayin , Jian Rongrong , Yu Jiangang , Zhi Xiuling , Liao Xiaohong , Yu Jerry , Zhou Ping
Published: October 2015

Extracellular adenosine, generated by ecto‐5′‐nucleotidase (CD73) via enzymatic catalyzation, has been found to facilitate atherosclerosis (AS). Thus, suppressing CD73 may attenuate AS. In this study, we evaluated the role of CD73 during AS development and further explored cellular and molecular mechanism in smooth muscle cells (SMCs). In a mouse model of carotid artery ligation, inactivation of CD73 inhibited migration and proliferation of vascular SMCs. In in vitro experiments, RNA interference of CD73 inhibited migration, proliferation, and foam cell transformation of human umbilical artery smooth muscle cells. Further, we established an atherosclerotic model using ApoE−/− mice fed with a western diet for 16 weeks. Inactivation of CD73‐attenuated AS and hyperlipidemia in ApoE−/− mice. In conclusion, our data suggest that CD73 facilitates AS by promoting migration, proliferation, and foam cell transformation of vascular SMCs and elevating serum lipid levels. Thus, inhibition of CD73 may be beneficial for prevention and treatment of AS. © 2015 IUBMB Life, 67(11):853–860, 2015
Evidence synthesis activities of a hospital evidence‐based practice center and impact on hospital decision making
Authors: Jayakumar Kishore L. , Lavenberg Julia A. , Mitchell Matthew D. , Doshi Jalpa A. , Leas Brian , Goldmann David R. , Williams Kendal , Brennan Patrick J. , Umscheid Craig A.
Published: October 2015

BACKGROUND

Hospital evidence‐based practice centers (EPCs) synthesize and disseminate evidence locally, but their impact on institutional decision making is unclear.

OBJECTIVE

To assess the evidence synthesis activities and impact of a hospital EPC serving a large academic healthcare system.

DESIGN, SETTING, AND PARTICIPANTS

Descriptive analysis of the EPC's database of rapid systematic reviews since EPC inception (July 2006–June 2014), and survey of report requestors from the EPC's last 4 fiscal years.

MEASUREMENTS

Descriptive analyses examined requestor and report characteristics; questionnaire examined report usability, impact, and requestor satisfaction (higher scores on 5‐point Likert scales reflected greater agreement).

RESULTS

The EPC completed 249 evidence reviews since inception. The most common requestors were clinical departments (29%, n = 72), chief medical officers (19%, n = 47), and purchasing committees (14%, n = 35). The most common technologies reviewed were drugs (24%, n = 60), devices (19%, n = 48), and care processes (12%, n = 31). Mean report completion time was 70 days. Thirty reports (12%) informed computerized decision support interventions. More than half of reports (56%, n = 139) were completed in the last 4 fiscal years for 65 requestors. Of the 64 eligible participants, 46 responded (72%). Requestors were satisfied with the report (mean = 4.4), and agreed it was delivered promptly (mean = 4.4), answered the questions posed (mean = 4.3), and informed their final decision (mean = 4.1).

CONCLUSIONS

This is the first examination of evidence synthesis activities by a hospital EPC in the United States. Our findings suggest hospital EPCs can efficiently synthesize and disseminate evidence addressing a range of clinical topics for diverse stakeholders, and can influence local decision making. Journal of Hospital Medicine 2016;11:185–192. © 2015 Society of Hospital Medicine
Improved synthesis and biological evaluation of Tc‐99m radiolabeled AMO for miRNA imaging in tumor xenografts
Authors: Kang Lei , Fan Zhongyi , Sun Hongwei , Feng Yingying , Ma Chao , Yan Ping , Zhang Chunli , Ma Huan , Hao Pan , Chen Xueqi , Zheng Zhibing , Xu Xiaojie , Wang Rongfu
Published: October 2015

MicroRNAs (miRNAs) have been considered as important biomarkers for malignant tumors. In this study, we introduced an improved 99mTc labeling method for noninvasive visualization of overexpressed miRNAs in tumor‐bearing mice. Anti‐miRNA‐21 oligonucleotide (AMO) with partial 2′‐O‐methyl and phosphorothioate modification was designed and chemically synthesized. After conjugated with NHS‐MAG3, AMO was labeled with 99mTc. Optimization was made to shorten reaction time and to improve labeling efficiency. Labeling efficiency was 97%, and specific activity was 2.78 MBq/ng. During 12 h, 99mTc‐AMO showed no significant degradation by gel electrophoresis. Its radiochemical purity was stable, between 95.8% and 99.1%. Further, 99mTc‐AMO decreased the level of miR‐21 and increased the expression of PTEN protein at cellular level, shown by qRT‐PCR and Western blot. Fluorescent protein labeled AMO displayed specific distribution and good stability in tumor cells. After the administration in tumor‐bearing mice, 99mTc‐AMO showed more radioactive uptake in the miR‐21 over‐expressed tumors than scramble control. Biodistribution results further proved the significant difference of tumor uptake between 99mTc‐AMO and 99mTc‐control. Therefore, this study presents an improved method with shorten time to prepare a 99mTc radiolabeled AMO. In addition, it supports the role of 99mTc‐AMO for noninvasive visualization of miR‐21 in malignant tumors.
Identification of phase I and II metabolites of the new designer drug α‐pyrrolidinohexiophenone (α‐PHP) in human urine by liquid chromatography quadrupole time‐of‐flight mass spectrometry (LC‐QTOF‐MS)
Authors: Paul Michael , Bleicher Sergej , Guber Susanne , Ippisch Josef , Polettini Aldo , Schultis Wolfgang
Published: October 2015

Pyrrolidinophenones represent one emerging class of newly encountered drugs of abuse, also known as ‘new psychoactive substances’, with stimulating psychoactive effects. In this work, we report on the detection of the new designer drug α‐pyrrolidinohexiophenone (α‐PHP) and its phase I and II metabolites in a human urine sample of a drug abuser. Determination and structural elucidation of these metabolites have been achieved by liquid chromatography electrospray ionisation quadrupole time‐of‐flight mass spectrometry (LC‐ESI‐QTOF‐MS). By tentative identification, the exact and approximate structures of 19 phase I metabolites and nine phase II glucuronides were elucidated. Major metabolic pathways revealed the reduction of the ß‐keto moieties to their corresponding alcohols, didesalkylation of the pyrrolidine ring, hydroxylation and oxidation of the aliphatic side chain leading to n‐hydroxy, aldehyde and carboxylate metabolites, and oxidation of the pyrrolidine ring to its lactam followed by ring cleavage and additional hydroxylation, reduction and oxidation steps and combinations thereof. The most abundant phase II metabolites were glucuronidated ß‐keto‐reduced alcohols. Besides the great number of metabolites detected in this sample, α‐PHP is still one of the most abundant ions together with its ß‐keto‐reduced alcoholic dihydro metabolite. Monitoring of these metabolites in clinical and forensic toxicology may unambiguously prove the abuse of the new designer drug α‐PHP. Copyright © 2015 John Wiley & Sons, Ltd.
Physics‐based mathematical model of 2DEG sheet charge density and DC characteristics of AlInN/AlN/GaN MOSHEMT
Authors: Jena Kanjalochan , Swain Raghunandan , Lenka T. R.
Published: October 2015

In this paper, a physics‐based analytical model for threshold voltage, two‐dimensional electron gas (2DEG) sheet charge density and DC characteristics of the proposed spacer layer‐based AlxIn1−xN/AlN/GaN metal‐oxide‐semiconductor high electron mobility transistor is presented by considering the quasi‐triangular quantum well. 2DEG sheet charge density (ns) is obtained by the variation of Fermi level (Ef) with supply voltage and the formation of energy subbands E0 and E1. An expression for the 2DEG sheet charge density (ns), valid in all regions of device operation, is studied and applied to derive drain current. The proposed model results for sheet charge density and drain current are calculated and verified with experimental data over a full range of applied gate and drain voltages. Scaling of DC performance is studied as a function of gate length to explore the design space of proposed metal‐oxide‐semiconductor high electron mobility transistor. Suppression in the forward gate current is observed because of the insertion of AlN spacer that made it possible to apply a high gate voltage in the transistor operation and is very useful for high power and high frequency applications. Copyright © 2015 John Wiley & Sons, Ltd.
The call for an increased role of replication, extension, and mixed‐methods study designs in organizational research
Authors: Wright Thomas A. , Sweeney Dennis A.
Published: October 2015

Examples from previously published work by the lead author on the role of employee health indicators on individual and organizational outcomes provide an intriguing backdrop through the use of illustration for suggesting some of the many benefits obtained by the incorporation of replication, extension, and mixed‐methods study designs in organizational research. Copyright © 2015 John Wiley & Sons, Ltd.
Correlation of size and oxygen bonding at the interface of Si nanocrystal in Si–SiO2 nanocomposite: A Raman mapping study
Authors: Rani Ekta , Ingale Alka A. , Chaturvedi A. , Kamal C. , Phase D. M. , Joshi M. P. , Chakrabarti A. , Banerjee A. , Kukreja L. M.
Published: October 2015

Raman spectroscopy/mapping is used to investigate the variation of Si phonon wavenumbers, i.e., lower wavenumber (LW ~ 495–510 cm−1) and higher wavenumber (HW ~ 515–519 cm−1) phonons, observed in Si–SiO2 multilayer nanocomposite (NCp) grown using pulsed laser deposition. Sensitivity of Raman spectroscopy as a local probe to surface/interface is effectively used to show that LW and HW phonons originate at surface (Si–SiO2 interface) and core of Si nanocrystals, respectively. The consistent picture of this understanding is developed using Raman spectroscopy monitored laser heating/annealing and cooling experiment at the site of the desired wavenumber, chosen with the help of Raman mapping. Raman spectra calculations for Si41 cluster with oxygen and hydrogen termination show strong mode at 512 cm−1 for oxygen terminated cluster corresponding to the vibration of surface Si atoms. This supports our attribution of LW phonons to be originating at the Si–SiO2 surface/interface. These results along with XPS show that nature of interface (oxygen bonding) in turn depends on the size of nanocrystals and LW phonons originate at the surface of smaller Si nanocrystals. The understanding developed can conclude the ongoing debate on large variation in Si phonon wavenumbers of Si–SiO2 NCps in the literature. Copyright © 2015 John Wiley & Sons, Ltd.
The venae comitantes clipping test for the evaluation of the venous drainage of the radial forearm free flap
Authors: Razzano Sergio , Esposito Luigi , Schonauer Fabrizio
Published: October 2015

Risks of failure of the radial forearm free flap (FRFF) are mainly related to venous congestion. Two different venous drainage system have been described for the FRFF, but the choice of the best one is still controversial. The superficial systems have a larger diameter and a thicker wall veins which makes them easier to anastomose. The deep system provides most part of the venous outflow if the caliber of the venae comitantes (VCs) is adequate. We propose an intra‐operative method to evaluate the FRFF venous drainage: the VCs clipping test. The test has been used in the choice of the vein to anastomose in 12 consecutive patients with oral cavity post oncological defects reconstructed with the FRFF. The cephalic vein was included in the flap; the VCs were individually clipped with small liga‐clips and divided with the radial artery still patent. The flap was kept with arterial inflow and superficial venous outflow till the recipient site was ready. If there were no signs of venous stasis, the VCs were kept clipped and the cephalic vein anastomosis was made. If clinical signs of venous stasis were revealed, the largest of the VCs was anastomosed to a vein of adequate caliber in the neck. No signs of flap venous congestion were observed in the postoperative period. No flap necrosis occurred. In this small series of patients the venae comitantes clipping test showed to be an easy, reliable and reproducible method to assess intra‐operatively which vein to anastomose. © 2015 Wiley Periodicals, Inc. Microsurgery 36:647–650, 2016.