bluuebunny/crossref_metadata_2025 huggingface dataset:
(Re)vision of Religious Education of Children and Youth in Secularized Polish Society
Authors: Zellma Anna
Published: March 2024

Rapidly progressing multifaceted secularization processes in Polish society strongly influence the shape of religious education of children and adolescents in the school environment. They determine a number of dimensions of the social and mental activity of young people. Their effects are visible, es­pecially in the attitudes of children and youth to God, the Church, religious lessons, moral norms, and religious practices. This situation raises new challenges for the religious education of the young. Reading this as a “sign of the times,” this article revises religious education in Polish schools. The need to reor­ganize the model of religious education lessons and to introduce changes in the curricular assumptions of religious education teaching, in student textbooks and methodological guides is pointed out. Pre-evangelization and educational activities, resignation from the mere transfer of religious knowledge, and the development of preconceived skills and attitudes are considered important. The author emphasizes the value of providing opportunities for the construction of knowledge and for the student’s own en­gagement during religious education lessons. In this context, much attention is paid to the role of the re­ligious education teacher, who is to be first and foremost a companion on a journey, an educator and a witness of faith, open to new challenges, able to communicate effectively with students, creative, and tolerant. The right personality traits of the religious education teacher and their multiple competencies (including communicative and interpersonal ones) play a key role in religious education. They guarantee the effectiveness of communication within a group of religious lesson participants. They foster authentic interpersonal relationships and community-building, thus meeting the natural needs of young people. In practice, they require a paradigm shift in the formation of religious education teachers.
Katechetyczne i psychologiczne aspekty przynależności do wspólnoty Kościoła w okresie wczesnej adolescencji
Authors: Kopiczko Tomasz , Dacka Monika
Published: March 2024

Okres wczesnej adolescencji, zarówno z punktu widzenia katechetyki, jak i psychologii, budzi wiele trudności, a zarazem stanowi wyzwanie dla refleksji naukowej i praktyki wychowawczej. Celem tego artykułu jest podjęcie interdyscyplinarnej refleksji nad przynależnością do wspólnoty Kościoła osób w okresie wczesnej adolescencji. Efekty podjętych poszukiwań naukowych pozwoliły na realizację celu w trzech istotnych punktach. Po pierwsze, jest to charakterystyka okresu wczesnej adolescencji z uwzględnieniem potrzeby przynależności. Po drugie, zostały ukazane wyzwania społeczne i kulturowe, które stanowią kontekst dorastającego człowieka. Trzeci element to wskazanie na konkretne propozycje rozwiązań, zmierzających w kierunku praktyki wychowywania w wierze. Dzięki zastosowaniu metody analitycznej i syntetycznej przebadano szereg tekstów teologicznych, psychologicznych oraz badań empirycznych. Pozwoliło to na wypracowanie wniosków oraz wskazanie na potrzebę troski o: właściwe relacje osobowe, wrażliwe towarzyszenie osobom młodym, prawidłowe przeniesienie doświadczeń oraz dbałość o poczucie wspólnoty.
Why More “Exodus” Is Needed in Church and Pastoral Care. Reflections on an Attitude-Forming Paradigm Shift
Authors: Loiero Salvatore
Published: March 2024

The relationship between secularity and religion/religiosity is a main topic of practical theol­ogy and ecclesiastical pastoral care. However, several research papers on religious studies show that the thesis that with disappearing institutionalized religiosity, plural and differentiated forms of religiosity increase is not convincing. In fact, the development shows that where people do not experience religion, it becomes irrelevant to them. This fact is an urgent question for the Church: With and from which basic attitude can and will she be able to encounter religious and secular people in such ways that the Christian gospel of human emancipation and redemption can become a reality in their lives? The Church can real­ize such a fundamental attitude in reference to the biblical Exodus and by generating a pastoral exodus.
Digital Innovations for Effective Management Analysis in the Context of Business Transformation
Authors: Hamkalo O. B. , Demkiv Kh. S.
Published: March 2024

The article considers theoretical and applied aspects of applying digital innovations in the system of organization and conducting management analysis of enterprise activities. The content of the concepts of digital innovations and business transformation in the system of management analysis is disclosed. The role of management analysis in the context of business transformation is determined. The main digital innovations that affect modern business and contribute to the effective management of an enterprise are considered. The study analyzes the use of digital innovations in the preparation and implementation of management decisions, formulates and discloses recommendations for their implementation in order to improve the efficiency of enterprise activities in the field of strategic planning, operational analysis and risk management. Examples of digital innovations for implementation in the enterprise management system for analysis, evaluation and strategic planning of its activities are provided. The main aspects of the use of digital innovations for management analysis are revealed. The challenges and difficulties associated with the introduction of digital innovations in the process of management analysis are analyzed, indicating possible impacts on the organizational structure, decision-making processes and strategic planning. Possible ways to overcome these obstacles are considered. It is determined how digital innovations change the approach to data collection, processing and analysis in the process of management analysis and allow obtaining more accurate and comprehensive data for decision-making. The article also examines the role of management analysis based on digital data in making informed decisions and developing optimal strategies for enterprise development and the ability to assess various scenarios, identify business strengths and weaknesses. The author also considers technological and analytical tools that support the effectiveness of management analysis in the context of digital innovations and affect the quality of enterprise performance. It is substantiated that digital technologies and data analysis are key factors in the successful transformation of enterprises to meet modern requirements. They help to improve the efficiency of business processes, identify new opportunities and provide competitive advantages in the market by changing the approach to business management and the way an enterprise interacts with its customers.
Development of Mechanical Engineering in the Conditions of Globalization (Experience of EU Countries)
Authors: Sozanskyy L. Yo.
Published: March 2024

The study was carried out with the aim of evaluating and substantiating the key systemic problems of the functioning of the national engineering industry of various countries in the conditions of economic globalization. In order to achieve the goal, development trends and key relative indicators of Polish and German mechanical engineering were analyzed during and under the influence of increased economic globalization. It is analytically substantiated that during the period of economic globalization, absolute indicators increased, in particular the volume of production and the number of employees of the Polish mechanical engineering industry, but instead, its innovativeness and technology decreased significantly, and dependence on foreign enterprises increased. It was revealed that the German engineering industry, in particular the automobile industry, has undergone significant destructive changes under the influence of increased economic globalization. First of all, this is a tendency to decrease the number of cars, and a significant decrease in the share of innovative products in the volume of sold industrial products of the production of motor vehicles, trailers and semi-trailers. It is concluded that the identified destructive changes are the result of an irrational, one-sided perception of economic globalization by the main business entities of these countries. In particular, this is the failure to take into account the systemic effects of foreign enterprises and TNCs, excessive export-orientation of products, offshoring, auto-sourcing on the activities of mechanical engineering and the socio-economic development of countries in general.

The obtained results of the study became the basis for the formation and analytical and theoretical-philosophical substantiation of the hypothesis that compliance with a high level of provision of production processes by national, not controlled from the outside, products of intermediate consumption and an optimal level of export-orientation of machine-building industries, along with a decrease in the level of monopolization in high-tech segments of the global economy, in the long term, will contribute to the satisfaction of the interests of both national economies (in particular, entrepreneurship and the social sphere), and TNCs.
Intrinsic apoptotic pathway and G2/M cell cycle arrest involved in tubeimoside I-induced EC109 cell death
Authors:   SchoolofPharmaceuticalSciences,XiamenUniversity, Xiamen361005,China, Yang Xu , Wang Guanghui ,   SchoolofPharmaceuticalSciences,XiamenUniversity, Xiamen361005,China
Published: March 2024

Squamous esophageal carcinoma is highly prevalent in developing countries, especially in China. Tu Bei Mu (TBM), a traditional folk medicine, has been used to treat esophageal squamous cell carcinoma (ESCC) for a long term. tubeimoside I (TBMS1) is the main component of TBM, exhibiting great anticancer potential. In this study, we investigated the mechanism of TBMS1 cytotoxic effect on EC109 cells. A comparative nuclear proteomic approach was applied in the current study and we identified several altered protein spots. Further biochemical studies were carried out to detect the mitochondrial membrane potential, cell cycle and corresponding proteins’ expression and location. Subcellular proteomic study in the nucleus from EC109 cells revealed that altered proteins were associated with mitochondrial function and cell proliferation. Further biochemical studies showed that TBMS1-induced molecular events were related to mitochondria-induced intrinsic apoptosis and P21-cyclin B1/cdc2 complex- related G2/M cell cycle arrest. Considering the conventional application of TBM in esophageal cancer, TBMS1 therefore may have a great potential as a chemotherapeutic drug candidate for ESCC.
LOW-DOSE LIPOSOMAL AMPHOTERICIN B IN REFRACTORY INDIAN VISCERAL LEISHMANIASIS: A MULTICENTER STUDY
Authors:   Kala-azar Medical Research Center, Banaras Hindu University, Varanasi, India, SUNDAR S. , JHA T. K. ,   Kala-azar Research Center, Muzaffarpur, India; Balaji Uthan Sansthan, Patna, India;, THAKUR C. P. ,   Kala-azar Research Center, Muzaffarpur, India; Balaji Uthan Sansthan, Patna, India;,   Kala-azar Research Center, Darbhanga, India; Gilead Sciences, Paris, France, MISHRA M. ,   Kala-azar Research Center, Darbhanga, India; Gilead Sciences, Paris, France, Singh V. P. ,   Kala-azar Research Center, Muzaffarpur, India; Balaji Uthan Sansthan, Patna, India;, BUFFELS D R. ,   Kala-azar Research Center, Muzaffarpur, India; Balaji Uthan Sansthan, Patna, India;
Published: March 2024

In this randomized, double-blind, dose-ranging, multicenter trial, 84 patients with visceral leishmaniasis refractory to antimony therapy were administered liposomal amphotericin B (AmBisome) at cumulative doses of 3.75, 7.5, and 15.0 mg/kg for 5 consecutive days. Posttreatment apparent cure and definite cure were assessed at 2 weeks and 6 months after the end of therapy, respectively. Mild to moderate infusion-related fever and rigors were seen in 29 and 44% of patients, respectively. One patient each in the 3.75- and 7.5-mg groups had detectable parasites on splenic smear at posttreatment evaluation. At 6 months follow-up, however, 2, 1, and 1 patients relapsed in the 3.75-, 7.5-, and 15.0-mg groups, resulting in definite cure rates of 89, 93, and 97%, respectively. There was no significant difference in the cure rates of the 3 groups. Low-dose liposomal amphotericin B given for 5 days can cure most patients with Indian kala-azar
Review: Insight of Medical Imaging for Precision Medicine In Focusing on Radiomics Aspect
Authors:   Department of Internal Medicine, Samarkand State Medical University, 18 Amir Temur St, Samarkand, Uzbekistan, Park Gippeum ,   scholargen Inc.,   Scholargen-Samarkand Inc., Annaev Muzaffar ,   Department of Internal Medicine, Samarkand State Medical University, 18 Amir Temur St, Samarkand, Uzbekistan, Zhang Ken Karl ,   Department of Intervention Radiology, Thomas Jefferson Medical College 11 Waverly PHB,  New York, NY 10003, Lee Hwunjae ,   Department of Radiology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea
Published: March 2024

Precision medicine is a revolutionary medical approach that takes into account individual variations in genes, environment, and lifestyle to tailor treatment and prevention strategies for each patient. One crucial aspect of precision medicine is medical imaging, which plays a fundamental role in the accurate assessment and diagnosis of diseases. By utilizing various imaging modalities, such as MRI, CT scan, and PET scan, doctors can obtain detailed information about a patient's condition and make informed decisions about the most effective therapeutic options. Furthermore, imaging techniques like radiomics have emerged as a promising tool in precision medicine. By extracting quantitative data from medical images, radiomics allows for objective and quantitative analysis of the biological characteristics of diseases. This information can then be correlated and integrated with genomic data to further enhance our understanding of diseases, a concept known as radiogenomics. Imaging plays a vital role in the development of precision medicine. Radiomics, based on high-throughput medical imaging, allows for the extraction of vast amounts of data from medical images to perform objective and quantitative analysis of the biological characteristics of diseases. This is crucial for tumor diagnosis, differential diagnosis, prognosis evaluation, and prediction of treatment response. Medical imaging, specifically radiomics, has greatly advanced the field of precision medicine by providing a comprehensive analysis of tumors and extracting quantitative data from medical images. This data can be correlated and integrated with genomic information to enhance our understanding of diseases and enable personalized treatment plans. In summary, medical imaging, particularly radiomics, plays a central and vital role in the development of precision medicine.
Hidratarea – o problemă de sănătate publică | [Hydration - a public health issue]
Authors: Marin-Ștefan Gabriela , Horhocea (Ștefan) Mihaela , Horhocea Daniel , Badea Mihaela
Published: March 2024

Introduction: Water has many functions in the human body. Hydration is under homeostatic control, through mechanisms that modify the elimination pathways, stimulating the appearance of the sensation of thirst. Dehydration is not a medical condition, but it is a common cause of death. Dehydration occurs when a person loses enough fluid, so the body no longer has enough fluid to perform its normal functions. Objective: This paper aims to highlight the level of knowledge about the importance of hydration in maintaining health. Materials and Methods: A cross-sectional study was designed using 175 subjects from Brasov (Romania), divided into two groups: sedentary group and athletes. The recruitment was thought for a determined period of time in a prospective way. It was administered questionnaires regarding the problem of correct hydration (adapted from the Plant LIBRA-245199 project and Beverage intake questionnaire -BEVQ). Results: Based on the responses of the study participants, it was observed that water is the most consumed liquid by them. The participants of the two groups felt the need to consume more water during the study and physical effort. Volunteers felt sleepier during the day if they don't drink enough fluids. Conclusion: It was observed that proper hydration reduces fatigue and creates a feeling of well-being. Water is the most consumed liquid by volunteers in both groups.
Rezumat
Introducere: Apa are multe roluri în organismal uman. Hidratarea se află sub control homeostatic, prin mecanisme care modifică căile de eliminare, stimulând astfel apariția senzației de sete. Corpul are nevoie de apă pentru a supaviețui și pentru a avea o bună funcționare. Deshidratarea nu este o boală, însă reprezintă o cauză frecventă de deces. Deshidratarea se instalează atunci când o persoană pierde o cantitate considerabilă de lichide, astfel încât organismul nu mai are suficiente fluide pentru a-și îndeplini funcțiile normale. Obiectiv principal al studiului: Lucrarea își propune evidențierea nivelului de cunoaștere despre importanța hidratării în menținerea sănătății ale voluntarilor participanți la studiu. Material și metodă: Studiu realizat este de tip transversal, folosind 175 de subiecți din Brașov (România), împărțiți în două loturi: sedentari și sportivi. S-au administrat chestionare privind problematica hidratării corecte (adaptat din proiectul Plant LIBRA-245199 și Beverage intake questionnaire -BEVQ). Rezultate: Pe baza răspunsurilor participanților la studiu, s-a observat că apa este cel mai consumat lichid de către aceștia. Voluntarii s-au simțit mai somnolenți în timpul zilei dacă nu au băut suficiente lichide. Concluzii: S-a observat că o hidratare adecvată reduce oboseala și creează o stare de bine. Apa este cel mai consumat lichid de către participanții din ambele grupuri.
Aspecte iatro-istorice în evoluția vaccinurilor – o privire sintetică | [Iatro-historical aspects in the evolution of vaccines – a synthetic view]
Authors: Radu Lavinia , Andrea Neculau , Spânu Daniela , Dinu Eleonora , Rogozea Liliana Marcela
Published: March 2024

Introduction: The perception of vaccines in the Romanian population has undergone a series of changes over time, leading to the reduction of the vaccination rate and even to the reappearance of some conditions, previously considered on the way to extinction. Like other countries, in Romania there is an anti-vaccine "movement", which intensified during the pandemic. The purpose of the study was to analyze the historical aspects of the development of different forms of vaccine, highlighting the evolution of concerns in this direction, followed by addressing the main myths and how they influence the acceptance or non-acceptance of vaccines and vaccination. Material and method: Historical documents, articles published in databases, such as Google Scholar, PUBMED, ISI, were analyzed. Results: Over time, vaccines have become an important ally during pandemics, but also in mankind's attempt to successfully eradicate some infectious-contagious diseases. Conclusions: From an ethical point of view, there will always be an attempt to answer the question: What is the ratio between benefit and adverse effects at the individual versus population level, and history can provide, at least partially, answers to this question.
Rezumat:
Introducere: Percepția vaccinurilor în populația României a suferit o serie de modificări de-alungul timpului, ducând la reducerea ratei de vaccinare și chiar la reapariția unor afecțiuni, considerate anterior pe cale de dispariție. Asemeni altor țări și în România există o „mișcare” antivacciniști, care s-a intensificat în perioada pandemiei. Scopul studiului a fost de analiza aspectele istorice ale dezvoltării diferitelor forme de vaccin, punând în evidență evoluția preocupărilor în această direcție, urmând ca ulterior să fie abordate principalele mituri și modul în care acestea influențează acceptarea sau neacceptarea vaccinurilor și vaccinării. Material și metodă: Au fost analizate documente istorice, articole publicate în baze de date, precum Google Scholar, PUBMED, ISI. Rezultate: De-a lungul timpului vaccinurile au devenit un aliat important în perioada pandemiilor, dar și în încercarea omenirii de a reuși eradicarea unor boli infecto-contagioase. Concluzii: Din punct de vedere etic va exista în permanență încercarea de a răspunde la întrebarea: Care este raportul dintre beneficiu și efecte adverse la nivel individual versus populațional, iar istoria poate oferi, cel puțin parțial răspunsuri la această întrebare.
DAMPAK PERTUMBUHAN EKONOMI DAN IPM TERHADAP KETIMPANGAN PENDAPATAN DI KABUPATEN/KOTA PROVINSI KEPULAUAN RIAU
Authors: Randa Fradya
Published: March 2024

Penelitian ini bertujuan untuk mengetahui pengaruh Pertumbuhan Ekonomi dan Indeks Pembangunan Manusia (IPM), terhadap ketimpangan pendapatan di Kabupaten/Kota Provinsi Kepulaun Riau. Penelitian ini menggunakan data panel periode 2011 hingga 2021 pada 7 Kabupaten/Kota Provinsi Kepulauan Riau. Hasil penelitian menunjukkan bahwa variabel pertumbuhan ekonomi mempunyai pengaruh positif terhadap ketimpangan pendapatan, tetapi tidak signifikan dan variabel IPM menunjukkan pengaruh negatif dan signifikan terhadap ketimpangan pendapatan. pemerintah perlu mengupayakan pembangunan ekonom secara merata sehingga pertumbuhan ekonomi dapat diarahkan untuk meningkatkan kualitas pembangunan manusia dan akan menurunkan ketimpangan pendapatan di Kabupaten/Kota Provinsi Kepulauan Riau.
Keputusan Pembelian Pangan Segar secara Online pada Masa Pandemi Covid-19
Authors: Safitri Laras , Fathurohman Ferdi
Published: March 2024

Perubahan perilaku konsumen selama pandemi Covid-19 terjadi pula pada keputusan pembelian pangan segar secara online. Penelitian ini bertujuan untuk mengidentifikasi karakteristik konsumen pangan segar secara online dan menganalisis proses pengambilan keputusan pembelian pangan segar secara online. Responden yang digunakan dalam penelitian ini berjumlah 77 orang yang diambil secara sengaja (purposive), sedangkan data yang diperoleh dianalisis secara deskriptif. Konsumen yang membeli pangan segar secara online didominasi oleh perempuan, berusia 24 – 37 tahun, status kawin, bekerja sebagai Ibu Rumah Tangga (IRT), berpendidikan S1 dengan tingkat pendapatan lebih dari Rp 5.000.000 per bulan, serta memiliki anggota keluarga sekitar 4 – 6 orang. Konsumen membeli pangan segar secara online dikarenakan ingin menjaga keamanan dan kesehatan selama pandemi. Sumber informasi yang mempengaruhi konsumen adalah sumber informasi pribadi. Adapun evaluasi alternatif konsumen dalam pembelian pangan segar secara online adalah kesegaran dan kebersihan produk, serta keamanan transaksi. Pembelian dilakukan dengan terencana sebanyak 1 -2 kali dalam sebulan. Setelah pembelian, konsumen cenderung memiliki tindakan untuk berpindah ke toko lain, baik online maupun offline jika terjadi kenaikan harga produk, kenaikan ongkos kirim, ketidaktersediaan produk yang diinginkan, dan ketersediaan promo atau diskon di toko lain.
Solvability of the inverse spectral problem for Sturm-Liouville operator with spectral parameter in the boundary condition
Authors:   Azerbaijan State Oil and Industry University (ASOIU), Mammadova Leyla , Nabiev Ibrahim ,   Baku State University
Published: March 2024

This paper deals with an inverse problem for the Sturm-Liouville operator with non-separated boundary conditions, one of which linearly depends on a spectral parameter. Uniqueness theorem is proved, solution algorithm is constructed and sufficient conditions for solvability of inverse problem are obtained. As spectral data, we only use the spectrum of one boundary value problem and some sequence of signs, and some number.
EULER-TYPE SYSTEM OF EQUATIONS IN VARIATIONAL PROBLEMS WITH DELAYED ARGUMENT
Authors:   Institute of Mathematics and Mechanics, Baku, Azerbaijan, M. Isayeva Aygun , J. Mardanov Misir
Published: March 2024

The article studies a closed-end variational problem with a delayed arguments. As a result, a system of equations with a delayed argument of Euler-type is obtained using the first variation of the functional for the extremum.
GELİR EŞİTSİZLİĞİ, YENİLENEBİLİR ENERJİ TÜKETİMİ VE EKONOMİK BÜYÜME İLİŞKİSİ: PANEL VAR YAKLAŞIMINDAN KANITLAR
Authors: Alev Nigar , Ersezer Özge
Published: March 2024

Gelişmiş ve gelişmekte olan ülkelerde gelir eşitsizliği ve yenilenebilir enerji tüketiminde artış yaşanmaktadır. Gelir eşitsizliğinin çevre kalitesi üzerindeki etkisi çeşitli çalışmalarda araştırılmış olsa da gelir eşitsizliğinin yenilenebilir enerji tüketimi üzerindeki etkisi yeterince araştırılmamıştır. Literatüre katkıda bulunmak adına bu çalışmada, MINT (Meksika, Endonezya, Nijerya ve Türkiye) ülkelerinde gelir eşitsizliği (Gini Katsayısı), yenilenebilir enerji tüketimi ve ekonomik büyüme arasındaki ilişki 2002-2020 dönemi için araştırılmıştır. Çalışmada Panel VAR ve Panel Granger Nedensellik metodolojisi kullanılmıştır. Panel VAR analizinden elde edilen bulgular, yenilenebilir enerji tüketimi üzerinde gelir eşitsizliğinin istatistiksel olarak anlamlı ve pozitif etkisinin olduğunu, ekonomik büyümenin olumlu ancak istatistiksel açıdan anlamlı etkisinin olmadığını ortaya koymuştur. Etki-tepki analizi sonuçlarına göre; gelir eşitsizliğindeki artış yönlü şoklar çoğunlukla yenilenebilir enerji tüketimi ve ekonomik büyüme üzerinde artan etkide bulunmakta, varyans ayrıştırma analizine göre ise incelenen dönem boyunca gelir eşitsizliği hem yenilenebilir enerji tüketiminde hem de ekonomik büyüme üzerinde önemli şoklara neden olmaktadır Son olarak Panel Granger Nedensellik analizi bulgularından gelir eşitsizliğinden yenilenebilir enerji tüketimine, gelir eşitsizliğinden ekonomik büyümeye ve yenilenebilir enerji tüketiminden ekonomik büyümeye doğru tek yönlü bir nedensellik ilişkisi tespit edilmiştir.
Accelerated technology for cleaning oil-contaminated soils
Authors: Degtyareva I. A. , Rakhmanova G. F.
Published: March 2024

Relevance. The uniqueness of the practical application of accelerated and environmentally safe technology for the reclamation of oil–polluted lands, which uses local mineral raw materials, a consortium of autochthonous hydrocarbon-oxidizing bacteria with multifunctional positive properties, effective phytomeliorants, is theoretically substantiated. Hydrocarbon pollution is eliminated directly at the spill site, and the rate ofreturn of disturbed soils to agricultural circulation is 3–4 times faster than traditional methods.

Methods. Objects of research: mechanically activated bentopowder and nanobentonite, a consortium of hydrocarbon-oxidizing bacteria composed of three autochthonous strains, soil leached chernozem, spring wheat, Devonian oil. The concentration of oil pollution at the site was 6.4%. Bentopowder and nanobentonite were introduced in doses of 6.0 t/ha and 0.3 t/ha, respectively. Sampling was carried out with a sampler on the 0th, 15th, 30th, and 90th days.

Results. The optimal doses of application of bento powder and nano bentonite to disturbed soil above the average pollution level (6.0 t/ha and 0.3 t/ha respectively) are recommended. After 15 days, the level of contamination is halved (to 51.1 g/kg and 40.8 g/kg with benton powder and nanobentonite respectively). Removal of the introduced mineral sorbent is not required, since it later becomes a source of mineral nutrition for autochthonous microorganisms-destructors and a soil improver. At the second innovative stage, a consortium formed from effective strains and adapted to specific conditions is used. The strains of the consortium fit into an ecological niche, adapt and begin to actively develop, utilizing oil and petroleum products. After a month, the level of contamination decreases to 19.2 g/kg and 9.2 g/kg with the addition of benton powder and nanobentonite respectively.
Soils of xerophytic meadows of the Middle Podesen’ya: on the issues of accumulation of organic substances and biochemical activity
Authors: Potsepai S. N. , Anishchenko L. N. , Semyshev M. V. , Atroshenko P. P.
Published: March 2024

Relevance. Natural meadow communities, belonging to the dry meadows group, in the conditions of a decrease in floodplain of the leading water artery in the Bryansk region — the Desna River are characterized by significant changes in the mode of economic use. However, a significant part of dry meadows is used as pasture lands, so the regime of intensive exploitation of these lands significantly changes the ecological regimes of phytocenoses, reducing the carbon-depositing functions. For xerophytic (dry) meadows of natural origin, the establishment of soil carbon reserves, the identification of biochemical and microbiological activity is especially important in the light of the low stability of these communities under pasture load and wide distribution throughout the territory of the Middle Podesen’ya.

Methods. The research provided for field route studies and in-house data processing using the methods of trial sites, the method of ecological and floral classification, the method of ecological scales (according to G. Ellenberg), ecological and chemical methods — determination of organic carbon, the weight method, biochemical and microbiological methods for the study of the biocompatible body.

Results. For the soils of xerophytic (dry) meadows, for the first time, carbon-absorbing capacity, enzymatic activity for urease, catalase, cellulase, depending on the phytocenotic complex, has been established for the Middle Podesen’ya. A positive strong correlation has been established with organic carbon and average monthly precipitation in June, July and August. Over a two-year observation period, the amount of total organic carbon in the soil changed in a number of associations communities: Festuco ovinae-Koelerium delavignei > control > Agrimonio eupatoriae-Poetum angustifoliae > Caro carvi-Deschampsietum > Anthoxantho-Agrostietum tenuis > Hieracio pilosellae-Agrostietum tenuis > Koelerio delavignei-Festucetum rubrae > Anthyllidi-Trifolietum montani > Polygalo vulgaris-Anthoxanthoetum.
Perspective of probiotic bacteria in the production of soy-based fermented products
Authors: Iakovchenko N. V. , Antsyperova M. A.
Published: March 2024

Relevance. It is worth noting that consumers’ awareness of the environmental burden that milk production carries continues to grow. Consumers are looking for alternatives that are more environmentally friendly and have high nutritional value. The demand for plant-based products is increasing for various reasons, namely, 65% of the world’s population has a reduced ability to digest lactose and 6% of the population is allergic to milk protein. According to statistics, 49% of women and 36.6% of men experience symptoms of functional gastrointestinal disorders. Soybeans are one of the most widely grown and consumed legumes worldwide. Thus, the development of new plant-based fermented products is a particularly actual issue.

Methods. The objects of study were soybean dispersion and microorganisms Lactobacillus, Bifidobacterium and Propionibacterium. The quality indicators of the resulting soy dispersion were determined. The process of acid accumulation during fermentation with probiotic microorganisms were studied. Data on the accumulation of bacterial biomass during the fermentation process were obtained and the effect of the use of selected starter microorganisms on the change in the antioxidant status of fermented dispersions during storage were investigated.

Results. Research results showed that soybean dispersion is a good substrate to produce fermented beverages using Lactobacillus, Bifidobacterium and Propionibacterium microorganisms. The most rapid process occurs when L. bulgaricus and P. schermanii KM-186 are used and the fermentation lasted for 6 hours. All selected strains adapt well to the plant-based media, but the greatest increase in biomass occurs during fermentation with L. bulgaricus, B. longum B379M and B. bifidum. Lactic acid and propionic acid bacteria provide high and stable levels of antioxidant activity on both the 1st and 6th and 12th days of storage.
The use of vitamin complex in combination with chemotherapy in theileriosis of cattle
Authors: Abdulmagomedov S. Sh. , Bakrieva R. M.
Published: March 2024

Relevance. In the Caspian region of Russia, blood parasitic diseases are one of the most common diseases of cattle, which cause significant economic damage to livestock farms due to reduced productivity and death of animals. According to natural and climatic conditions and zonal features, the Republic of Dagestan is a favorable habitat for ixodic mites, the main carriers of pyroplasmidosis pathogens, in particular Theileria annulata. In spring, cattle with impaired resistance, weakened after wintering, are seriously ill with pyroplasmidosis, especially teileriosis, after getting over the gum, rumination, intestinal work, milk yield, and general reaction to the environment recover to physiological norm for a long time. In this regard, further improvement of existing and the search for new methods that ensure maximum conservation of animals from these invasions, with minimal effort and money, remains an urgent task. The aim of the study was to determine the effectiveness of “Delagil” in the combined use of “Ursoferanforte” in spontaneous bovine taileriosis.

Methods. Methods for determining therapeutic efficacy were formed by experimental and control groups of 30 heads of different ages with spontaneous tayleriosis in varying degrees of severity of the disease with a temperature reaction within 40.4 ± 0.03 — 41.5 ± 0.09 °C, parasitemia — 5.47 ± 0.3 — 25.18 ± 0.31% in 100 fields of view of the microscope. In the control group, “Delagil” was used in its pure form at a dose of 2 g / 100 kg (20 mg / kg by DV) (orally) with water in the form of a suspension. In the experimental group, treatment was carried out comprehensively — “Delagil” in the indicated doses in combination with the drug “Ursoferan-forte” in a dose of 10–25 ml (once, intramuscularly).

Results. The use of antimalarial “Delagil” in combination with the drug “Ursoferan-forte” (in combination) increases the effectiveness to 93.3% and avoids significant economic losses. Currently, the safety of susceptible animals from teileriosis is becoming possible with the combined use of chemotherapeutic drugs.
The conjugation of productive features of dairy cattle of the Holstein breed
Authors: Kanev P. N. , Gorelik O. V. , Kharlap S. Yu. , Gorelik A. S. , Rebezov M. B.
Published: March 2024

Relevance. Currently, in the Sverdlovsk region, more than 75% of the total number of cattle belongs to the Holstein breed, created by absorbing domestic black-and-white cattle into Holsteins. The study of the variability of the productive qualities of cows during lactation is important for identifying the possibility of increasing productive longevity and the efficiency of breeding and using Holstein cattle of the Ural selection in the conditions of the Middle Urals.

Methods. The study was conducted in one of the typical livestock complexes of the Holstein black-and white cattle breed in the Sverdlovsk region. All cows that completed four lactation periods were included in the assessment. Milk productivity was assessed by control milks, milk quality indicators: MJ and MDB in milk in an average milk sample from each cow, once a month correlation coefficients between productive characteristics were calculated in the Uralplemcenter dairy laboratory. The automated program “SELEX. Dairy cattle.”

Results. As a result of the conducted studies, it was found that significantly more milk was produced from age-and-sex cows during the third lactation than during the first and second, as well as the fourth lactation (p ≤ 0.01 — for the first, p ≤ 0.05 — for the second and fourth). The live weight significantly increased with age in the second lactation at p ≤ 0.01 relative to the first, and from the third onwards — at p ≤ 0.001 relative to the first lactation. There is a tendency to decrease the mass fraction of fat (MJ) in milk and a simultaneous increase in MDB with age from the first to the fourth lactation. When carrying out breeding work, it is possible to take into account the positive correlation coefficients for predicting the further milk productivity of cows according to the milk yield of the first heifers, the invariance of milk quality indicators with changes in milk yield and the positive effect of live weight of cows on their productivity. The research is exploratory and was carried out within the framework of scientific research of the Ural State Agrarian University (state registration No. AAAA19-1191014000069).
ﺟﻨﺎحﺍﻟﺬل ﻓﻲﻣﻨﻆﻮرﺍﻟﺸﻴﺦ ﻣﺘﻮﻟﻲ ﺍﻟﺷﻌﺮﺍﻮﻱ ﻓﻲ ﺗﻔﺳﻴﺮﻩ
Authors: Fadhlurrahman Zulfi , Mas’ud Abdurrahman
Published: March 2024

هذه رسالة تحاول كشف معنى كل ألفاظ في القرآن الكريم من ناحية أسرار اللغة  وبدراسة دلالية تحليلية. وعلى سبيل المثال، لفظ جناح الذلّ، كثير من الباحثين وبعض المفسرين يستخدمون تفسير لفظ جناح الذلّ في سورة الإسراء الآية 24 لنتائج التربية فحسب. ولذالك يبحث الباحث لفظ جناح الذلّ من ناحية دقيق علم اللغة العربية من تفسير خواطري حول القرآن الكريم للشيخ متولي الشعراوي، وكما يعرف الباحث أن الشيخ متولي الشعراوي حينما يفسر كل ألفاظ في القرآن دقيقا وواسعا بنظرية العلوم اللغوية. وفي هذه الرسالة، استخدم الباحث طريقة الدراسة المكتبية في مطالعة الكتب المتعلقة بوثائق العلوم عن لفظ جناح الذلّ خصوصا في كتاب تفسير خواطري حول القرآن الكريم للشيخ متولي الشعراوي وبعض كتب التفسير الأخرى. ولحلّ المسألة في هذه الرسالة العلمية استخدم الباحث طريقتين وهما المنهج الوصفي لجمع البيانات ذات الصلة ووصفها، والمنهج التحليلي لتحليل البيانات التي قد جمعت من قبل. ونتائج البحث في هذه الرسالة أن الشيخ متولي الشعراوي يقول أن لفظ جناح الذلّ هو أن الحق سبحانه وتعالى يدعونا أن نقتدي من امثلة الطائر وأن نعامل الوالدين هذه المعاملة كاطائر الذي يحنو على صغاره، ولفظ جناح الذلّ كناية عن الطاعة والحنان والتواضع للوالدين، وينهى الشيخ متولي الشهراوي أن نكون كالطائر الذي يرفع جناحيه ليطير بهما متعاليا على غيره والمقصود هو التكبر على الوالدين وغيرهما، ومن آداب المعاملة للوالدين من معنى لفظ جناح الذلّ يعني الطاعة والحنان والخضوع والتواضع لهما
РОЗРОБЛЕННЯ ТЕХНОЛОГІЇ ПРЯНО-АРОМАТИЧНИХ ЕКСТРАКТУ І ЙОГО ВИКОРИСТАННЯ ПРИ ВИГОТОВЛЕННІ ФРУКТОВО-ОВОЧЕВОГО СМУЗІ
Authors: Жмудь Альона , Осипова Лариса , Коваленко Лілія
Published: March 2024

Це дослідження зосереджено на розробці передових методів виготовлення продуктів функціонального харчування, зокрема на ефективності використання кропу та петрушки в рецептурі смузі. Вивчається оптимальний метод вилучення хлорофілу та інших біоактивних складових з кропу та петрушки, де застосовується інтегрований підхід, що включає пресування та водне екстрагування. Встановлено, що соки кропу та петрушки мають високий вміст хлорофілу, незважаючи на його обмежену розчинність у воді. Дослідження показує, що в водному середовищі хлорофіл утворює розчинні комплекси з білками, що значною мірою переходять у сік під час пресування. Решта хлорофілу, асоційована з біополімерами, зберігається у жмиху, який після пресування може додатково абсорбувати біоактивні речовини з води завдяки своїй гігроскопічності. Процес включає сорбцію ароматичних і барвних компонентів біополімерами, що знаходяться у продуктах, здатних взаємодіяти з кількома молекулами цих речовин, що пояснює переваги екстрагування для отримання більшої кількості комплексних сполук. Проведено вибір та аналіз первинної сировини та напівфабрикатів, демонструючи сумісність компонентів, таких як яблуко, топінамбур і пряно-ароматичний екстракт, і розроблено рецептуру смузі на їх основі. Вказано на дієтичну та біологічну цінність готового напою, а також на його спосіб запобігання потемнінню завдяки використанню барвних складових кропу та петрушки. Розроблений смузі рекомендовано до включення в щоденний раціон для підтримки здорового способу життя, вважаючи подальше дослідження важливим для розширення асортименту продукції з використанням пряно-ароматичних екстрактів.
ВИЗНАЧЕННЯ ОСОБЛИВОСТЕЙ КОНТУРІВ ДНА ВЕРХНЬОЩЕЛЕПНИХ ПАЗУХ У ПАЦІЄНТІВ ІЗ РІЗНОЮ ФОРМОЮ ЛИЦЕВОГО СКЕЛЕТА ПІД ЧАС ПІДГОТОВКИ ДО ОПЕРАЦІЇ ВІДКРИТОГО СИНУС-ЛІФТИНГУ
Authors: Мокрик О.Я. , Сороківський І.С. , Ружицька О.В. , Лещишин Н.І. , Касіян Д.В.
Published: March 2024

Найчастішим інтраопераційним ускладненням відкритого синус-ліфтингу є перфорація мембрани Шнайдера. Топографо-анатомічні особливості верхньощелепної пазухи, форма та контури її дна можуть суттєво впливати на ефективність елевації слизової оболонки дна пазухи під час цього хірургічного втручання. Розміри та конфігурація верхньощелепних пазух статистично значуще корелюють із параметрами середньої частини лицевого скелета. Мета дослідження – визначити на комп’ютерних томограмах індивідуально-анатомічні особливості контурів дна верхньощелепних пазух у пацієнтів із різною формою лицевого скелета та встановити серед них можливі предиктори перфорації мембрани Шнайдера під час операції відкритого синус-ліфтингу. Матеріали дослідження. Краніометричні дослідження проводили на КТ-зображеннях 92 черепів. Визначали лицевий індекс за формулою Гарсона, в коронарній проєкції черепів виявляли контури дна верхньощелепних пазух, при їх зрізах на рівні лунок першого та другого молярів, згідно з класифікацією L. Niu, J. Wang та співавторів (2018). Для встановлення вірогідних відмінностей у топографо-анатомічних показниках, отриманих у групах порівняння, обчислювали критерій узгодженості Пірсона χ2. Наукова новизна. Уперше виявлено залежність деяких контурів дна верхньощелепних пазух від форм лицевого відділу черепів пацієнтів. Встановлено серед них можливі анатомічні предиктори перфорації мембрани Шнайдера під час операції відкритого синус-ліфтингу. У хамепрозопів у 27,8% випадків діагностувались контури дна верхньощелепних пазух неправильної форми – нерівні з виїмками (заглибинами) чи зигзагоподібні або з наявністю перегородок/екзостозів. Контури дна пазухи вузької (конічної) форми найчастіше присутні у лептопрозопів – χ2 = 4,02 (р˂ 0,05). Ці топографо-анатомічні чинники ускладнюють механічне відшарування мембрани Шнайдера від кортикальної пластинки дна верхньощелепної пазухи, сприяють її розриву. Водночас у мезопрозопів виявлено у 22,5% випадків контури дна верхньощелепної пазухи квадратної форми, а у 32,5% – овальної форми, вони не перешкоджають повноцінній елевації мембрани Шнайдера. Висновки. Контури дна верхньощелепних пазух неправильної форми (із заглибинами чи зигзагоподібні, з наявністю перегородок/екзостозів) частіше трапляються у хамепрозопів (широколицих) – у 27,8% випадків, а дно цієї пазухи вузької (конічної) форми частіше присутнє у лептопрозопів (вузьколицих) – χ2 = 4,02, р˂ 0,05, що є прогностичними факторами перфорації мембрани Шнайдера у разі відкритого синус-ліфтингу й необхідно враховувати під час планування цього хірургічного втручання.
How do the Swiss Spend their Time?
Authors: Winkler Caroline , Axhausen Kay W.
Published: March 2024

Time use statistics are widely documented in order to track societal trends. The most reliable and widely used collection method for time use data are diaries in which a person documents all activities participated in for a given period. This study uncovers daily time use patterns across the entire adult population of German-speaking Switzerland with such data. The findings are the first diary-based account of time use for the region and illuminate important differences between genders and based on parenthood status in terms of paid and unpaid work, as well as working from home.
The role of manual correction methods and extracorporeal shock wave therapy in the prevention of chronic tension headaches
Authors: Guseva T. S. , Naprienko M. N. , Smekalkina L. V.
Published: March 2024

Introduction. Tension-type headache is an urgent problem in the modern medicine due to a significant decrease in the efficiency and quality of patient′s life, despite the benign nature of the disease.

The aim of the study is to develop and scientifically substantiate the comprehensive application of extracorporeal shock wave therapy and manual methods of preventive treatment of the chronic tension-type headache.

Materials and methods. The prospective randomized study included 90 patients with tension-type headache (chronic), G44.2, and 20 healthy patients in the age from 24 to 50 years. Participants were divided into 3 equal groups with 30 participants in each one. In the I group the pharmacotherapy with amitriptyline was performed, in the II group — manual treatment, and in the III group — complex rehabilitation with manual methods of treatment and extracorporeal shockwave therapy. Additionally, 20 healthy patients were included in the study (group IV). To assess the treatment effectiveness the following methods were used: a headache diary, manual examination, NRS scale, HADS scale.

Results. The data obtained demonstrated that the combined use of manual treatment and extracorporeal shock wave therapy, as well as single-impact manual treatment methods, contributes to clinical improvement to a greater extent than pharmacotherapy. A comparative analysis of the study groups in the long-term follow-up period (after 3 months) showed more significant results in the group with comprehensive rehabilitation, which is clearly reflected in the form of a significant decrease in pain intensity and overall pain score. The methods used significantly improved the psycho-emotional status of patients, however, pharmacotherapy with amitriptyline was accompanied by side effects.

Conclusion. The comprehensive application of extracorporeal shock wave therapy and manual methods of treatment leads to a significant improvement in both clinical and psycho-emotional states of patients with tension-type headache.
Radiological and morphological features of vanishing lung syndrome development in patients with COVID-19 community-acquired viral pneumonia
Authors: Yakovenko O.K. , Lynnyk M.I. , Liskina I.V. , Ignatieva V.I. , Gumeniuk G.L. , Palivoda M.G.
Published: March 2024

BACKGROUND. Presently actively new direction develops in digital treatment of CТ images – radiomics, that presents the result of co-operation on verge of different sciences (radiology, computer sciences and mathematical statistics). Inaccessible for the unarmed eye additional information of CT images can be got by means of their mathematical treatment and creation of the segmented histograms. Last it is possible to compare and analyse both isolated and with regard to the dynamics of physiopathology descriptions of organs and fabrics at the different human diseases.

OBJECTIVE. To define the roentgenologic and morphological features of development of vanishing lung syndrome for patients with non-hospital viral pneumonia.

MATERIALS AND METHODS. Data of CТ are analysed in a dynamics for patients with non-hospital viral pneumonia of COVID-19, that were on treatment in SI “National institute of phthisiology and pulmonology named after F.G. Yanovsky of the NAMS of Ukraine” or were directed from other medical establishments. The Dragonfly program from Object Research Systems (Montreal, Canada), which performs micro-X-ray structural analysis of the examined tissues, was used to analyze CT images of chest. Pathomorphological examination was performed in the laboratory of pathomorphology of the institute.

RESULTS. Monitoring of CT is conducted in the group, that consisted of 90 patients with non-hospital viral pneumonia of COVID-19. 27 (30,0 %) patients (18 men and 9 women in age from 23 to 68) are educed with the roentgenologic signs of vanishing lung syndrome. 12 from them (9 men and 3 women in age from 23 to 56) were on treatment in the institute in an acute period of disease. Other 15 patients (9 men and 6 women in age from 26 to 68) directed from other curative establishments, where they treated oneself 3-4 months ago.

CONCLUSIONS. Micro-X-ray structural analysis of data of CT allows to educe the features of changes of parenchima at development of vanishing lung syndrome. These changes are confirmed by the educed changes at pathomorphological research of postoperative preparations of lungs.