bluuebunny/crossref_metadata_2025 huggingface dataset:
Atuação do enfermeiro na reabilitação da saúde da pessoa com deficiência
Authors: Da Silva Naara Rayssa Nascimento , De Macêdo Amanda Cavalcante , De Melo Géssyca Cavalcante , Duprat Irena Penha , Sobrinha Edivânia dos Santos , Da Silva Ana Lybia de Oliveira Bezerra , Gomes Tales Luiz dos Santos , Carnaúba Maria Clarisse Soares , Rocha Amanda Priscilla Pereira
Published: February 2021

Objetivo: Descrever a atuação do enfermeiro na reabilitação de pessoas com deficiência. Métodos: Revisão integrativa de literatura. As bases consultadas foram Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Base de Dados de Enfermagem (BDENF) e Scientific Electronic Library Online (SciELO). Incluídos artigos científicos que abordam a atuação do enfermeiro na reabilitação da saúde da pessoa com deficiência, escritos em português, inglês e espanhol, disponíveis gratuitamente. Não foi estabelecido limite temporal a fim de contemplar toda a produção até o momento. Excluídos artigos de reflexão, editoriais e revisão. A amostra final foi 18 artigos. Resultados: Estudos brasileiros totalizaram 83,3% da amostra. Após análise, emergiram seis eixos relacionados à atuação do enfermeiro na reabilitação da pessoa com deficiência: enfermeiro como educador (66,6%); enfermeiro como ser político e com compromisso social (55,5%); enfermeiro como implementador de cuidados (50%); enfermeiro como pesquisador (27,7%); enfermeiro como mediador entre paciente, família e equipe multiprofissional (22,2%); e enfermeiro como gerente da equipe de Enfermagem (11,1%). Considerações Finais: O enfermeiro atua de forma multidimensional no cenário relacionado à pessoa com deficiência, envolvendo além do cuidado direto, o gerenciamento de equipes, mediação do processo de trabalho em saúde, gestão através da implementação de políticas públicas e pesquisa científica.
EXPLORING THE HOTSPOTS AND FRONTIERS OF CORPORATE GOVERNANCE IN EMERGING MARKETS: A BIBLIOMETRIC ANALYSIS BASED ON WEB OF SCIENCE CORE COLLECTION AND CITESPACE
Authors: Pasko Oleh , Li Zhang
Published: February 2021

Through using co-citation analysis, this paper presents a general picture of the research hotspots and research frontiers in corporate governance in emerging markets. Paper’s sample for analysis consists of 2980 original research articles and review articles dated 2000-2019, retrieved from Web of Science Core Collection. With the help of the whole variety of tools, CiteSpace offers authors conduct a visual domain analysis of corporate governance in emerging markets research. The findings allow authors to conclude that current research hotspots are corporate governance, emerging markets, corporate social responsibility, firm performance, ownership structure, etc. Besides, thirteen still active terms are collected from the Strongest Citation Bursts that can be considered as the research fronts of corporate governance in emerging markets. The latest citation bursts that smoothly flow into the present are: panel data (2017-2019), Indian firms (2017-2019), moderating role (2017-2019) and institutional ownership (2017-2019) and the longest citation burst streak are associated with audit committee (2016-2019). This study has provided a scientometric review that could be valuable to those who are interested in this topic and complement other types of research in this field.
Yeni Bir Anlam Çerçevesi/Paradigma Arayışı
Authors: GÜLPINAR Mehmet Ali
Published: February 2021

Giriş:Eğitim dahil olmak üzere tüm alanlarda karşı karşıya olduğumuz problemlerin niteliği bizi bu problemleri paradigma düzeyinde ele almaya ve yeni paradigma arayışlarına zorlamaktadır.Yöntem:Derleme (görüş ve değerlendirme) türünde olan bu yazıda, ilgili literatür taranarak tıp eğitimi de dahil olmak üzere bilim ve eğitim dünyasında tartışılan yeni paradigma arayışları ele alınmış ve bu tartışmalar için taslak bir çerçeve ile birlikte öğrenme ve değerlendirmeye ilişkin kavramsal ve kuramsal çerçeveler oluşturma denemesine girilmiştir. Bulgular:Bu taslak çerçevenin makro çerçevesini Varoluş Felsefesi, Karmaşıklık Bilimleri ve eğitimde sosyo-kültürel yapılandırmacı yaklaşım oluşturmuştur. Çerçevenin merkezi kavramları ise şu şekilde belirlenmiştir: “karmaşıklık”, “bağlamsallık”, “sınır, yaratıcı mesafe ve bağlanma”, “karşılıklı etkileşim ve dönüşüm” ve “birlikte yapılandırma ve birlikte gelişim”. Bu makro çerçeve ve merkezi kavramlar esas alınarak eğitim çıktılarına dayalı yaklaşım, yapılandırmacı eğitim ve öğrenme yaklaşımları, eğitim programı, ölçme-değerlendirme, program değerlendirme, öğrenen merkezli öğrenme kuramları ve modelleri ile öğrenme ortamına/iklimine ilişkin mevcut kuramlar tartışılmıştır. Bu yaklaşıma ve kuramlara yönelik son yıllarda yapılan eleştiriler ele alınmıştır. Eğitimde sistem yaklaşımı, “karmaşık sistem” anlayışı çerçevesinde yeniden değerlendirilmiştir. Gerek eğitim programı gerekse ders kurulu, blok, staj ve seçmeli programlar gibi öğrenim programları sadece çıktıya dayalı değil aynı zamanda sürece dayalı gelişimsel bir yaklaşımla “bağlamsal program” kavramlaştırması üzerinden yeniden çerçevelendirilmeye çalışılmıştır. Sosyokültürel yapılandırmacı yaklaşım benimsenerek öğrenme ve değerlendirme süreçleri, “etkileşim merkezli reflektif / bağlamsal öğrenme ve değerlendirme” deneyimleri şeklinde ele alınmıştır. Son olarak “karmaşıklık” ve “bağlamsallık” esas alınarak, program değerlendirme süreçlerinin “süreç”, “bağlam”, “çıktı” ve “etki” arasındaki karşılıklı etkileşim ve dönüşüm çerçevesinde ele alınmasına ilişkin görüşlere yer verilmiştir.Sonuç:Bu yazı ile karmaşıklık, bağlamsallık, karşılıklı etkileşim/dönüşüm ve birlikte yapılandırma/birlikte gelişim kavramları üzerinden öğrenmeye, öğrenme ortamına/iklimine ve program değerlendirmeye ilişkin üç kavramsal ve kuramsal çerçeve geliştirilmiştir. Bu çerçeveler taraflara tıp eğitimi süreçlerini farklı bir paradigma üzerinden ele alma fırsatı sunmaktadır.
Analysis of automatically extracted white blood cell DNA yield
Authors: Олькова М.В. , Балановская Е.В. , Бычковская Л.С. , Балановский О.П.
Published: February 2021

Все более широкое применение поточных методов экстракции ДНК влечет за собой необходимость стандартизации и проверки качества ее выделения. Мы провели детальное количественное изучение процесса выделения и определили стандартизирующие опорные точки для одного из наиболее производительных методов - выделения на магнитных частицах с использованием автоматической станции QIAsymphony SP. Показано, что концентрация ДНК в индивидуальном образце в основном определяется содержанием лейкоцитов в исходном образце крови (корреляция около 0,9). Концентрация ДНК также зависит от метода измерения. Это позволило нам построить линейные регрессионные модели и вывести формулы, точно прогнозирующие концентрацию ДНК в образце для случаев применения двух широко распространенных методов - спектрофотометрического (Nanodrop) и флуоресцентного (Qubit). Обнаружено, что последняя модель Nanodrop OneC, благодаря встроенному алгоритму идентификации примесей и корректировки концентрации, дает более точную оценку концентрации, чем Qubit 4.0. Для быстрого, но приблизительного прогноза концентрации ДНК вместо регрессионных моделей могут применяться стандарты, рассчитанные нами для референсных значений содержания лейкоцитов.

The continuing development of mass DNA extraction methods entails the need to set standardisation and quality verification reference points. A study has been conducted and standards set for one of the many methods of DNA extraction - the automated мagnetic beads-based extraction using QIAsymphony SP station. It was shown that the concentration of DNA in an individual sample is mainly determined by the leukocyte content in the initial blood sample (correlation of about 0.9). DNA concentration also depends on the measurement method. It allowed us to build linear regression models and derive formulae that accurately predict the concentration of DNA in the sample for the use of two widely used methods - spectrophotometric (Nanodrop) and fluorescence (Qubit). It was found that the latest Nanodrop OneC model, thanks to a built-in algorithm for identifying impurities and adjusting the concentration, provides an even more accurate concentration estimate than Qubit 4.0. For a quick but rough forecast of DNA concentration, instead of regression models, standards calculated by us for reference values of the white blood cell count can be used.
Effects of CYP2D6 gene polymorphism 1846G>A on lexotan efficiency and safety in patients with anxiety disorders comorbid with alcoholism
Authors: Закиров Ф.Х. , Застрожин М.С. , Смирнов В.В. , Петухов А.Е. , Панкратенко Е.П. , Застрожина А.К. , Гришина Е.А. , Рыжикова К.А. , Буре И.В. , Скрябин В.Ю. , Шипицын В.В. , Брюн Е.А. , Сычев Д.А. , Рожнова Т.М.
Published: February 2021

Тревожные расстройства, занимая важное место в психиатрии, нередко коморбидны и с другими заболеваниями. При этом актуальным становится изучение факторов, влияющих на индивидуальные различия в эффективности препаратов и выраженности их побочных эффектов у разных пациентов. Одним из важнейших таких факторов является генетический. В данной работе исследовалось влияние полиморфизма 1846G>A гена CYP2D6 на показатели эффективности и безопасности препарата лексотана у пациентов с тревожными расстройствами и алкогольной зависимостью.

Аnxiety disorders are considered a serious problem of psychiatry being comorbid with other states. In this context investigation of factors responsible for unequal drug efficiency and safety in different patients is needed. Among these factors, genetics is considered to be one of the most important. This study assessed the role of CYP2D6 gene polymorphism 1846G>A in Lexotan efficiency and safety in patients with anxiety disorders comorbid with alcoholism.
Association of polymorphic variants of xenobiotic biotransformation genes and glutation metabolizing genes with clinical course of cystic fibrosis, antimicrobial therapy efficacy and adverse reactions
Authors: Новоселова О.Г. , Кондратьева Е.И. , Петрова Н.В. , Шерман В.Д. , Воронкова А.Ю. , Зинченко Р.А.
Published: February 2021

Тяжесть клинических проявлений муковисцидоза может быть обусловлена действием генов-модификаторов. Выяснение причин неэффективности терапии и нежелательных побочных реакций, определение факторов риска позволит улучшить прогноз для данной категории больных. Исследованы ассоциации 18 полиморфных вариантов 10 генов ферментов первой и второй фазы биотрансформации ксенобиотиков: CYP2C9 (c.430C>T, c.1075A> C), CYP2C19 (c.681G>A), CYP2D6 (1846G>A), CYP3A4 (c-392C>T), GSTT1 (del), GSTM1 (del), GSTP1 (c.313A>C), GCLC (TVR GAG, c.-129C>T), GCLM (c.-588C>T), NAT2 (c.282C>T, c.341T>C, c.434A>C, c.481C>T, c.590G>A, c.845A>C, c.857G>A) с тяжестью клинических проявлений муковисцидоза.

CF clinical variability could be associated with interaction of modifier genes. Сlarification of the causes of treatment failure and adverse reactions, prediction of risk factors could improve the outcome of therapy. Association of 18 polymorphic variants of 10 genes of xenobiotic biotransformation: CYP2C9 (c.430C>T, c.1075A> C), CYP2C19 (c.681G>A), CYP2D6 (1846G>A), CYP3A4 (c-392C>T), GSTT1 (del), GSTM1 (del), GSTP1 (c.313A>C), GCLC (TVR GAG, c.-129C>T), GCLM (c.-588C>T), NAT2 (c.282C>T, c.341T>C, c.434A>C, c.481C>T, c.590G>A, c.845A>C, c.857G>A) with severity of clinical manifestations were analyzed in 333 CF patients.
Ethical problems of mitochondrial replacement
Authors: Введенская Е.В.
Published: February 2021

Применение любой новой вспомогательной репродуктивной технологии, связанной с манипуляциями человеческими половыми клетками и эмбрионами неизбежно будет спорным с этической точки зрения. Такой технологией является митохондриальное замещение, которое позволяет родить здорового ребенка женщине, страдающей митохондриальным заболеванием.

The use of any new assisted reproductive technology related to the manipulation of human sex cells and embryos will inevitably be controversial from an ethical point of view. This technology is mitochondrial replacement, which allows a woman suffering from mitochondrial dysfunction to give birth to a healthy child.
Genetics and social sciences: common research challenges and opportunities for «convergence»
Authors: Долгов А.Ю.
Published: February 2021

В статье рассматриваются социальные изменения, к которым приводит применение генетических технологий, обсуждается, как результаты генетических исследований влияют на язык социальных наук. Показываются «точки пересечения» генетических и социальных исследований.

The article discusses the social changes resulting from the application of genetic technologies and examines how the genetic research affect the language of social sciences. The «meeting points» between genetic and social research are shown.
The impact of the use of genetic technology on the rights of future generations
Authors: Попова О.В. , Серова О.А.
Published: February 2021

В исследовании определена значимость этических и правовых норм для регулирования применения генетических технологий. Эта задача является важной для современного общества, но не менее актуальной она представляется для определения рисков применения генетических технологий на права будущих поколений. Материалом стали научные статьи и электронные ресурсы. Методами исследования выбраны формально-логический, системный, структурно-функциональный и формально-догматический. Полученные результаты свидетельствуют о том, что тема заботы о будущих поколениях не должна игнорироваться при использовании генетических технологий. Правовые инструменты смогут определить пределы использования генетических технологий с учетом интересов будущих поколений.

The study determines the significance of ethical and legal norms for regulating the use of genetic technologies. This task is important for modern society, but it is no less relevant for determining the risks of applying genetic technologies to the rights of future generations. The material was scientific articles and electronic resources. The research methods are formal-logical, system, structural-functional and formal-dogmatic. The results show that the topic of caring for future generations should not be ignored when using genetic technologies. Legal instruments will be able to determine the limits of the use of genetic technologies, taking into account the interests of future generations.
Current problems of providing medical care for patients with orphan diseases in the Russian Federation
Authors: Гайдук А.Я. , Власов Я.В. , Захарова Е.Ю.
Published: February 2021

В статье обобщен опыт помощи пациентам с редкими заболеваниями, история развития «орфанной» медицины, проводится обзор зарубежных стратегий и основополагающих документов, формирующих современные модели оказания помощи пациентам с орфанными заболеваниями. Освещаются проблемы оказания медицинской помощи данной группе пациентов в Российской Федерации, в том числе в рамках программ «14 высокозатратных нозологий» и «17 нозологий» (17 жизнеугрожающих хронических прогрессирующих редких (орфанных) заболеваний), анализируются механизмы финансирования лекарственного обеспечения, их правовые основы, а также роль медико-генетической службы, как ключевого элемента в системе оказания медицинской помощи пациентам с редкими болезнями. В работе также приведен анализ региональных российских и зарубежных скрининг-программ, обзор актуальных диагностических методов и опыта их внедрения и использования. Авторы также затрагивают вопросы, касающиеся биотехнологических инноваций в российской и зарубежной медицине, подчёркивая актуальность, эффективность и, в некоторых случаях, незаменимость генной терапии. В заключение авторы резюмируют наиболее значимые задачи, стоящие перед орфанной медициной в Российской Федерации, а также вносят предложения по их решению.

The article summarizes the world experience in helping patients with rare diseases, the history of the development of “orphan” medicine, reviews foreign strategies and the fundamental documents that form the modern foreign models of care for patients with orphan diseases. The problems of providing medical care to this group of patients in the Russian Federation are highlighted, including in the framework of the programs “14 high-cost nosologies” and “17 nosologies” (17 life-threatening chronic progressive rare (orphan) diseases). The difficulties associated with the operation of the existing system of medical care for orphan patients are highlighted, including data on assessing the lack of information on management and on the procedure for providing information about patients with rare nosologies to the appropriate structures in the medical environment. The work also analyzes regional Russian and foreign screening programs, a review of relevant diagnostic methods and the experience of their implementation and use. The authors also address issues related to biotechnological innovations in Russian and foreign medicine, emphasizing the relevance, effectiveness and, in some cases, the indispensability of gene therapy. In conclusion, the authors summarize the most significant issues and challenges facing orphan medicine in the Russian Federation, as well as make suggestions for their solution.
Helsmoortel-van der Aa syndrome syndrome in a patient with epilepsy, developmental delay, intellectual disability and autism spectrum disorder
Authors: Кожанова Т.В. , Жилина С.С. , Мещерякова Т.И. , Лукьянова Е.Г. , Осипова К.В. , Айвазян С.О. , Заваденко Н.Н. , Притыко А.Г.
Published: February 2021

Синдром Хельсмуртел-Ван дер Аа (OMIM #615873) - аутосомно-доминантная умственная отсталость, тип 28, которая характеризуется наличием черепно-лицевых дисморфий, нарушением поведения и расстройствами аутистического спектра. Развитие редкого синдрома связано с мутациями в гене ADNP. В статье представляется клиническое наблюдение пациентки с задержкой психомоторного и речевого развития, специфическими лицевыми дисморфиями, нарушением поведения и выявленной мутацией в гене ADNP. При проведении таргетного экзомного секвенирования выявлен ранее неописанный вариант нуклеотидной последовательности в гене ADNP (p.Ala1017fs). Мутации в гене ADNP в гетерозиготном состоянии описаны у пациентов с синдромом Хельсмуртел-Ван дер Аа (Helsmoortel-van der Aa syndrome; MIM:#615873). Мутации в гене ADNP могут быть генетической причиной расстройств аутистического спектра у 0,17% пациентов. Целесообразно при интерпретации данных NGS у пациентов с эпилептической энцефалопатией, расстройством аутистического спектра и характерным фенотипом учитывать, что ген ADNP относится к ключевым генам эмбрионального развития нервной системы.

Helsmoortel-van der Aa syndrome (OMIM # 615873) is an autosomal dominant mental retardation 28 type, which is characterized by dysmorphic craniofacial features, impaired behavior and autism spectrum disorders. The development of a rare syndrome is associated with mutations in the ADNP gene. The clinical case is presented in patient with a development delay (psychomotor and speech), characteristic facial dysmorphia, impaired behavior and a detected mutation in the ADNP gene. Previously undescribed variant of the nucleotide sequence in the ADNP gene (p.Ala1017fs) was detected by targeted exome sequencing. Heterozygous mutations in the ADNP gene have been described in patients with Helsmoortel-van der Aa syndrome (MIM: # 615873). Mutations in the ADNP gene can be a genetic cause of autism spectrum disorders in 0,17% of patients. It is advisable to take into account that the ADNP gene is one of the key genes for embryonic neurodevelopment when interpreting NGS data in patients with epileptic encephalopathy, autism spectrum disorder and characteristic facial dysmorphia.
Prenatal cytogenetic diagnostics in Kursk genetic counselling
Authors: Железнова М.А. , Комкова Г.В. , Вялых Е.К.I. , Ржевкина Н.Н. , Кононова М.В.
Published: February 2021

Представлены данные об эффективности пренатальной диагностики хромосомной патологии плода в медико-генетической консультации г.Курска.

The results of analyzes the effectiveness of prenatal diagnostics for identifying the fetal chromosomal pathology in the medical-genetic consultation of Kursk.
Co-expression network analysis of placental transcriptome as the basis for searching signal ways and preeclampsia biomarkers
Authors: Бабовская А.А. , Трифонова Е.А. , Зарубин А.А. , Марков А.В. , Степанов В.А.
Published: February 2021

Проблема профилактики и ранней диагностики преэклампсии (ПЭ) продолжает оставаться одной из ведущих в акушерстве, поскольку данное осложнение беременности несет большой риск материнской и младенческой смертности. Считается, что основная причина ПЭ - это нарушение этапов формирования плаценты, а регуляции экспрессии генов является значимым механизмом развития плацентарной патологии. Классический подход в транскриптомных исследованиях экспрессии основан на поиске дифференциально-экспрессирующихся генов при заболевании, однако такой подход рассматривает гены изолированно, не учитывая их возможные взаимодействия. Более перспективным подходом является анализ коэкспрессии, который описывает гены, вовлеченные в единые биологические пути патологического процесса, а также позволяет выделять в каждом из кластеров наиболее функционально значимый ген в сети - центральный (hub gene).

The problem of prevention and early diagnosis of preeclampsia continues to be one of the leading in obstetrics. It`s a major problem that contributes substantially to maternal and perinatal morbidity and mortality worldwide . Gene expression contributes significantly to the pathogenesis of placental diseases. Traditional methods of studying gene expression are based on the search of differentially expressed genes in a disease, but this approach considers genes in isolation. Coexpression analysis describes the genes involved in the unified biological pathways of the pathological process and also allows you to select in each of the clusters the most functionally significant gene in the network - the hub gene.
Transcriptomics of placental tissue: identification of molecular mechanisms and measures for targeted therapy of grate obstetric syndromes
Authors: Трифонова Е.А. , Марков А.В. , Степанов И.А. , Ижойкина Е.В. , Степанов В.А.
Published: February 2021

Многочисленными исследованиями показано, что ключевые патогенетические механизмы больших акушерских синдромов (БАС) связаны с нарушением процессов плацентации. В связи с чем, целью нашей работы являлся поиск новых генетических маркеров этих гестационных осложнений на основе интегративного анализа данных, полученных при полногеномном экспрессионном профилировании плацентарной ткани. Нами выявлено 64 гена, транскрипционная активность которых статистически значимо изменяется как минимум при двух заболеваниях группы БАС. Показана значимая роль нарушения межклеточных взаимодействий и регуляции модификации белков в плацентарной ткани при развитии изученных патологических состояний беременности, идентифицированы мастер-регуляторы, рассматриваемые в качестве потенциальных терапевтических мишеней.

It is shown that the key pathogenetic mechanisms of grate obstetric syndromes (GOS) are associated with impaired placentation. The aim of the work was to search for new genetic markers of GOS on the basis of integrative analysis of genome-wide expression profiling data. We found that the transcriptional activity of 64 genes changes in at least two GOS diseases. The significant role of disturbance of intercellular interactions and regulation of protein modification in placental tissue during the development of the pregnancy complications is shown. Master regulators that are potential therapeutic targets have been identified.
Tissue-specific deconvolution of cell composition using miRNA sequencing data
Authors: Зарубин А.А. , Марков А.В. , Слепцов А.А. , Назаренко М.С.
Published: February 2021

Экспрессия микроРНК (miRNA) изменяется под действием различных факторов, что создаёт проблему интерпретации результатов исследований, поскольку патологические процессы могут изменять не только функциональную активность клеток, но и соотношения клеточных популяций. Возможным решением является применение подходов клеточной деконволюции. Нами был разработан алгоритм создания референсной панели экспрессии miRNA, специфичной для определенных типов клеток, что позволяет оценить представленность различных клеточных популяций в стенке артерий. Показано, что существующие алгоритмы деконволюции подходят для данных miRNA.

The expression of miRNAs is affected by different factors. This poses challenges when interpreting the results of the study. Pathological processes can influence both the functional activity of cells and the ratio of cell populations. A possible solution is to utilize the approaches of deconvolution. We have developed an algorithm to assess reference panel from the microRNA dataset on the example of artery walls. In this study, we have shown that existing deconvolution algorithms are suitable for miRNA data.
The importance for standardization and validation of real-time PCR for the detection of mature miR-21 in the blood of patients
Authors: Шуленина Л.В. , Салеева Д.В.
Published: February 2021

Процессы обнаружения и количественного определения методом ПЦР в реальном времени в крови пациентов зрелых микроРНК, в том числе и miR-21, должны быть стандартизированы и валидированы. Проведенные нами исследования, показывают, что специфичность метода ПЦР для miR-21 в крови здоровых доноров может быть демонстрирована образованием продукта-ампликона размером 67 нуклеотидов, прецизионность в условиях сходимости и воспроизводимости, выраженная в виде коэффициента вариации, составляет менее 2% и 3 % соответственно, а линейность метода подтверждается коэффицентом корреляции r≥0,99.

The processes of detection and quantification by real-time PCR in blood of mature microRNAs, including miR-21, should be standardized and validated. Our studies show that the specificity of PCR method for miR-21 in the blood of healthy donors can be demonstrated by the formation of a 67 bp amplicon product, precision under conditions of convergence and reproducibility, expressed using the coefficient of variation, is less than 2% and 3%, respectively, and the linearity of PCR method for miR-21 is confirmed by the correlation coefficient r≥0.99.
Training of specialists in laboratory genetics: experience in developing the assessment tools and problems in organizing the procedure for primary specialized accreditation
Authors: Вавилова Т.В. , Калинина О.В. , Пуппо И.Л. , Черныш Н.Ю. , Сироткина О.В.
Published: February 2021

В работе рассмотрены вопросы подготовки к процедуре первичной специализированной аккредитации по специальности Лабораторная генетика

The paper considers the issues of preparation for the primary specialized accreditation procedure in the laboratory genetics
Medical Genetics as a discipline translating modern knowledge and achievements of omics technologies into the clinical practice of future doctors
Authors: Солодилова М.А. , Асанов А.Ю. , Бушуева О.Ю. , Иванов В.П. , Полоников А.В.
Published: February 2021

Целью данной публикации был анализ структуры и содержательной части учебных программ и планов, использующихся для преподавания дисциплины «медицинская генетика» в медицинских ВУЗах Российской Федерации. В статье рассматриваются проблемы современного медицинского образования через призму значимости преподавания медицинской генетики, интегрирующей современные достижения омиксных технологий для понимания этиологии и патогенеза болезней с целью внедрения полученных знаний в клиническую практику будущих врачей различных специальностей.

The purpose of this publication was to analyze the structure and content of educational programs and plans used in medical universities of the Russian Federation for teaching subject Medical Genetics. The article discusses the problems of modern medical education through the prism of the importance of teaching Medical Genetics integrating the modern achievements in omics technologies for understanding the etiology and pathogenesis of diseases with subsequent application of this knowledge to clinical practice of future doctors of various medical specialties.
ANALYSIS OF COOPERATION BETWEEN CLASS XII IIS 2 STUDENTS IN MUHAMMADIYAH 1 PONTIANAK HIGH SCHOOL
Authors: Isman Heryana M
Published: February 2021

This study aimed to describe the spontaneous cooperation, contracts, and traditional inter IIS 2 class XII students at SMA Muhammadiyah 1 Pontianak. The method used is qualitative approach. The results showed that spontaneous cooperation among students have been executed better, but not perfect because there are students who are less well spontaneous cooperation. Besides the cooperation contract between the students has been reached with the good, it is characterized by cooperation between students when carrying picket class and their prayer materials to other students. While the traditional cooperation between students has also been going well between them visible influence each other as well as snacks at canteen, there is always one of the students who invited more friends for snacks at canteen together, and call it received good response by other friends to be said that these interactions may affect the behavior of other individuals by creating social relations among them
ANALISIS UPAYA GURU DALAM MEMOTIVASI SISWA PADA PROSES PEMBELAJARAN SOSIOLOGI KELAS XI IPS2
Authors: Berry Berry
Published: February 2021

The title of this research is "Analysis of Teacher Efforts to Manage Students in the Learning Process IPS2 Sociology Class XI". The purpose of this study was to determine and describe the efforts of teachers to motivate students in the learning process IPS2 sociology class XI. The approach used in this study is a qualitative approach with descriptive methods. The process of implementation is carried out with test instruments such as observation, interviews, and documentation.The results showed that the efforts of teachers to motivate students in the learning process of sociology in general have been implemented but have not carried out to the maximum. Constraints implementation of motivation by teachers, teacher attendance factors and methods of teaching, the student's social environment, and infrastructure are less supportive. The response of students is very worth noting that the way teachers deliver the material time in the classroom, because the volume is not loud teachers.
MAKNA SIMBOLIK BARU PADA MASJID AGUNG JAWA TENGAH
Authors: Kasim Muhammad Aqil
Published: February 2021

This study aims to find out the new symbolic meaning that lies in the Masjid Agung Jawa Tengah (MAJT) and the commodification process that occurs. This study uses a qualitative method and interpretivism approach. The source of the data resulted from interviews conducted with the administrators, merchants, and visitors in the Masjid Agung Jawa Tengah and observations of archives, photos, and electronic media about Masjid Agung Jawa Tengah. The result of this study shows that the visitors come to Masjid Agung Jawa Tengah for tourism and to fulfill their curiosity desire about the magnificent architecture of Masjid Agung Jawa Tengah. Later, the visitors feel excited and satisfied after they visit Masjid Agung Jawa Tengah. Furthermore, Masjid Agung Jawa Tengah becomes the medium to deliver spiritual and material value to the visitors. Today, many people are looking for economic benefits from Masjid Agung Jawa Tengah. The administrator makes Masjid Agung Jawa Tengah as a place to earn a living. It is the same condition with the merchant and travel startup which looking for economic benefits from the imagery of the Masjid Agung Jawa Tengah
Peningkatan Keterampilan Menulis Cerita Pendek Menggunakan Media Pop Up Pada Siswa Kelas V Sdn 36 Sungai Ambawang Kabupaten Kubu Raya
Authors: Kariyah Kariyah
Published: February 2021

The purpose of the study was to improve short story writing skills using POP UP media for fifth grade students of SDN 36 Sungai Ambawang, Kubu Raya Regency. This research method is descriptive method, the form of classroom action research, and the nature of collaborative research. Teachers' researchsubjects, and grade V students of State Elementary Schools totaling 20 students. The technique used in this study is direct observation techniques and data collection tools used are observation guidelines. The results of the study are based on observations using POP UP media in improving short story writing skills. By using POP UP media can improve short story writing skills. This can be seen from the learning outcomes of students in writing short stories seen from the achievement score of wholeness of the firstcycle 88.33% Cycle II 100%, Integrity of the essay score of the first cycle achievement 68.33%, second cycle 88.33%, while the achievements score on language and spelling cycle I 60% cycle II 86.66%. Based on the description, in general the use of POP UP media can improve the short story writing skills of fifth grade students at SDN 36 Sungai Ambawang, Kubu Raya Regency. Thus the POP UP media can be used in learning short story writing skills.
Pemberdayaan Masyarakat Nelayan Di Desa Sejahtera Kecamatan Sukadana Kabupaten Kayong Utara
Authors: Sikwan Agus
Published: February 2021

The title of this research is: “The Empowerment Program Model of the Poor Society in Sungai Raya Subdistrict which at Bengkayang Regency of West Borneo Province”. Background overshadow by writer desire to lay open until where program the Economic Empowerment of Coastal area Society (EECS) especially to fisherman Society which has been programmed by ambulatory Regency Government. Internal issue formulation this research is “What will be implementation process program the Economic Empowerment of Coastal area Society (EECS) at Sungai Raya Sub-district, Regency Bengkayang ? Research Type use qualitative and technique of data collecting use the in-depth interview and observation. While data analysis uses descriptive analysis. Program EECS at Sungai Raya Subdistrict of Regency Bengkayang to in the implementation of since the year 2007 is not re-continued. This matter because of some problems and factor influencing its implementation, so that program the EECS 2007 is even transferred to Regency area/other Subdistrict. Therefore, need the correct stages: steps and quickly in handling it, is good the then Government of Regency of Bengkayang and also institution or institute which have the competence of so that program EECS earn the implementation and re-continued because very needed by fisherman society especially in Sungai Raya Subdistrict.
Pengendalian Sosial Penggunaan Smartphone Anak Bersekolah Di Madrasah Aliyah Babussalam Desa Peniraman
Authors: Sulaiman Sulaiman
Published: February 2021

This thesis is entitled: social control by parents in the use of smartphones in children who are still in school at Madrasah Aliyah Babussalam Peniraman Pinyuh River District. The general problem of this research is social control by parents in the use of smartphones in children who are still in school at Madrasah Aliyah Babussalam Peniraman Pinyuh River sub-district. Sub problem in this research is 1: How persuasive social control by parents of children in the use of smartphones 2: How repressive social control by parents of children in the use of smartphones 3: How curative social control by parents of children in the use of smartphones. This study used a qualitative approach with descriptive methods. Observation data collection techniques, interviews, and documentation study with data collection tool guide observation, interviews, books, and archival records. Informal in this study are the parents and children. The positive impact for children to use the smartphone is to facilitate the child to seek material from school assignments, and berkomonikasi. But the negative impact of such children concentrates less on learning, lazy learning. The results of this research show that parents have been doing social control in children's benefit persuasive, repressive, and curative. But the negative impact of such children concentrates less on learning, lazy learning. The results of this research show that parents have been doing social control in children's benefit persuasive, repressive, and curative. But the negative impact of such children concentrates less on learning, lazy learning. The results of this research show that parents have been doing social control in children's benefit persuasive, repressive, and curative.
RUSSIAN ETATISM AND RUSSIAN PATERNALISM IN THE POLITICAL PROCESS OF RUSSIA ON THE EVE OF PETER THE GREAT’S REFORMATION
Authors: Omelchenko N. A.
Published: February 2021

The article сonsiders ideological, political and cultural prerequisites of the Peter the Great state reforms that, according to the author, were formed long before the Peter`s Reformation, and had a significant impact on the course and model of the “regular” (military- police) state created by Peter the First. Among the main prerequisites are the etatization (nationalization) of society and the associated paternalistic nature of state relations, which formed the traditional foundations of national statehood and strengthened in the 17th century in the context of Russia’s withdrawal from the Turmoil and the restoration of the national statehood destroyed in the time of troubles. The paper investigates the reasons for the formation of these features of the development of national statehood, the main of which the author proposes to search in the civilizational and geopolitical features of the formation and evolution of the Russian state, the weakness of the institutional foundations of Russian politics, stylistic peculiarities of Russian Orthodoxy and a number of other factors.
ALL-RUSSIAN CIVIL IDENTITY IN THE OFFICIAL DISCOURSE OF THE REPUBLICS OF NORTHERN CAUCASUS
Authors: Karsanova E. S.
Published: February 2021

The article considers the issue of formation of the all-Russian civil identity, actualized in the domestic political discourse. The paper reviews the phenomenon of identity as a dialogical and discursive phenomenon. In order to determine the main trends in the development of the North Caucasian republics, the author investigates regional practices of implementing the Strategy of State National Policy, internal political and inter-ethnic relations, migration processes. The study emphasizes the necessity of finding special formats of socio- political organization of the subjects of the Northern Caucasus region, expressing not only their local and ethno-cultural characteristics, but coping with the function of consolidation and co-optation of local communities in national socially and politically significant processes. As a result of the analysis of the problem of general civil identity generation the author concludes that these problems are primarily due to the contradictory dichotomy of identification processes that provoke competition and confrontation between ethnic and civil identities. In different objectively proposed circumstances the ambivalent manifestation of identity in the majority of Northern Caucasus peoples can act as a destructive, and a factor in the growth of All-Russian civil identity.
Data-Driven Discovery and Synthesis of High Entropy Alloy Hydrides with Targeted Thermodynamic Stability
Authors: Witman Matthew , Ek Gustav , Ling Sanliang , Chames Jeffery , Agarwal Sapan , Wong Justin Chuan-Chi , Allendorf Mark , Sahlberg Martin , Stavila Vitalie
Published: February 2021

Solid-state hydrogen storage materials that are optimized for specific use cases could be a crucial facilitator of the hydrogen economy transition. Yet the discovery of novel hydriding materials has historically been a manual process driven by chemical intuition or experimental trial-and-error. Data-driven materials' discovery paradigms provide an alternative to traditional approaches, whereby machine/statistical learning (ML) models are used to efficiently screen materials for desired properties and significantly narrow the scope of expensive/time-consuming first-principles modeling and experimental validation. Here we specifically focus on a relatively new class of hydrogen storage materials, high entropy alloy (HEA) hydrides, whose vast combinatorial composition space and local structural disorder necessitates a data-driven approach that does not rely on exact crystal structures in order to make property predictions. Our ML model quickly screens hydride stability within a large HEA space and permits down selection for laboratory validation based not only on targeted thermodynamic properties, but also secondary criteria such as alloy phase stability and density. To experimentally verify our predictions, we performed targeted synthesis and characterization of several novel hydrides that demonstrate significant destabilization (70x increase in equilibrium pressure, 20 kJ/molH2 decrease in desorption enthalpy) relative to the benchmark HEA hydride, TiVZrNbHfHx. Ultimately, by providing a large composition space in which hydride thermodynamics can be continuously tuned over a wide range, this work will enable efficient materials selection for various applications, especially in areas such as metal hydride based hydrogen compressors, actuators, and heat pumps.
Efficient and High Colour Purity RGB OLEDs Employing Densely Packed Dimers
Authors: Wang Kai , Fan Xiao-Chun , Tsuchiya Youichi , Shi Yi-Zhong , Tanaka Masaki , Lin Zesen , Lee Yi-Ting , Zhang Xiang , Liu Wei , Dai Gao-Le , Chen Jia-Xiong , Wu Bing , Zhong Jun , Yuan Jian-Yu , Zheng Cai-Jun , Yu Jia , Lee Chun-Sing , Adachi Chihaya , Zhang Xiaohong
Published: February 2021

Thermally activated delayed fluorescence (TADF) has been considered an important development in organic light-emitting diodes (OLEDs) for significantly enhancing efficiency of pure organic emitters. However, TADF is often associated with boarder emission spectra not meeting the requirements of modern high-performance flat-panel displays. A recent breakthrough in TADF emitters is the development of multiple resonance (MR) emitters which have a narrow spectral band width, i.e., good colour purities. However, so far molecular design for MR emitters is still much restricted and their emission peaks are covering only in a very limited range between ~ 460 to 510 nm. Herein, by exploiting a new emitting mechanism of densely packed dimer enhanced MR TADF, we demonstrate for the first time of highly efficient electroluminescence covering the RGB full colour with narrow spectral widths using pure organic emitters. MR-structured compounds with symmetry-forbidden n-π* transition for fluorescence are employed. They form intimate molecular interaction in their dimer states, leading to substantial changes in the S1 electronic structure into π-π* transition and much smaller singlet-triplet energy offset, which can significantly enhance TADF characteristics. The fluorescence efficiency increases tremendously to approach unity upon dimer formation. More importantly, molecular relaxations are strongly restricted in the systems due to their robust MR typed monomer frameworks as well as their strong dimer interaction. By applying these MR dimers in OLEDs, highly efficient narrow emission spectra can be achieved with full-width at half maximum of 32, 44, and 64 nm for blue, green, and red, respectively. Particularly, the green OLED realizes a remarkable maximum external quantum efficiency of 31%. Our strategies not only provide a pathway for realizing narrow emission covering full RGB emission range via intermolecular emitting systems (dimers, excimers, exciplexes, etc.) for the first time, but also exploit a new emitting mechanism leading to state-of-the-art performance among all reported OLEDs.
Bone mineral density in patients with thalassemia major, the experience of a single institute
Authors: Ahmed I Ansaf  , Safa A Faraj  , Rahan A Mohammed
Published: February 2021

Thalassemia is an inherited disorder causing an imbalance in the development of the globin chain with ineffective erythropoiesis and increased peripheral consumption. Expansion of bone marrow decreases bone mineral density. Bone disease in thalassemia is manifested as diffuse bone pain, scoliosis, spinal deformities, nerve compression, spontaneous fracture. Bone Mineral Density (BMD) is a useful indicator for bone monitoring and assessment and significant predictor of bone disease in thalassemia. The purpose of this study is to evaluate Bone Mineral Density in thalassemia patients and its correlation with other factors. The study was conducted in Hematology Center at Al-Karama Teaching Hospital, Wasit, Iraq, from the first of January to the thirty of April 2019. Fifty-eight thalassemia patients were enrolled in this study. Bone mineral density was assessed using Dual-Energy X-ray Absorptiometry technique (DEXA scan) for the lumber spine (L1-L4) at the Dexa unit in the rehabilitation Center in KUT. The patients were divided according to BMD by Z-Score ≤ 15 years old patients, T score for adults (>15 years old) into three groups: a score ≥ -1 defined as Normal BMD, Osteopenia (between −1 and −2.5 SD), and Osteoporosis (below −2.5 SD). The effect of Gender, Age, frequency of blood transfusion, Hb level, Serum Calcium, and Serum Ferritin on BMD was evaluated. Young patients (with age equal to or younger than 15 years) showed lower bone density than older patients. Also, Patients with Suboptimal blood transfusion had lower bone density than patients than good compliance blood transfusion program, P-value 0.001, 0.012, respectively. The results indicated a direct relationship between the age of the thalassemia patients and bone mass density, P-value = 0.0001, Pearson Correlation = 0.7. Low bone density was reported in young age and suboptimal blood transfusion.
Biological control methods in Piper nigrum Linn. leaves infected with galls caused by Liothrips karneyi
Authors: Asha Renjith  , Payal Lodha
Published: February 2021

Piper nigrum Linn. (Black pepper)  belongs to the family Piperaceae and an economically and medicinally important spice and is a native of Southern India. Leaf marginal gall is transmitted by Liothrips karnyi belonging to family Phlaeothripidae of order Thysanoptera (Thrips). Insect induced galls arise due to growth reaction of plants due to the attack of cecidozoa, also known as zoocecidia. The growth and development of the host plant alter due to the infestation of the insect, which involves certain complex phenomena. The different groups of cecidozoa influence the plants in such a way as to produce galls at different stages in their life history. Most of the cecidozoa cause galls only in their developmental stages, but some of them are capable of inducing galls both in larval as well as adult stages. The crop production in India has been adversely affected due to the infestation of pests. And it is necessary to use different approaches of disease management to curb the infestation, and significant researchers have shown progress to protect the crops in an eco-friendly manner. Piperine exhibits diverse pharmacological activities like antihypertensive, antiplatelets, antioxidant, antitumor, antipyretic, analgesic, anti-inflammatory, anti-diarrheal, antibacterial, antifungal, anti-reproductive, insecticidal activities. In the present investigation, the biological method of disease management of marginal leaf gall transmitted by Liothrips karnyi has been undertaken. The biological control of leaf diseases has been significant on the increased reflection of environmental problems over pesticide uses.