bluuebunny/crossref_metadata_2025 huggingface dataset:
New advances in protein engineering for industrial applications: Key takeaways
Authors: Ndochinwa Giles Obinna , Wang Qing-Yan , Okoro Nkwachukwu Oziamara , Amadi Oyetugo Chioma , Nwagu Tochukwu Nwamaka , Nnamchi Chukwudi Innocent , Moneke Anene Nwabu , Odiba Arome Solomon
Published: June 2024

Recent advancements in protein/enzyme engineering have enabled the production of a diverse array of high-value compounds in microbial systems with the potential for industrial applications. The goal of this review is to articulate some of the most recent protein engineering advances in bacteria, yeast, and other microbial systems to produce valuable substances. These high-value substances include α-farnesene, vitamin B12, fumaric acid, linalool, glucaric acid, carminic acid, mycosporine-like amino acids, patchoulol, orcinol glucoside, d-lactic acid, keratinase, α-glucanotransferases, β-glucosidase, seleno-methylselenocysteine, fatty acids, high-efficiency β-glucosidase enzymes, cellulase, β-carotene, physcion, and glucoamylase. Additionally, recent advances in enzyme engineering for enhancing thermostability will be discussed. These findings have the potential to revolutionize various industries, including biotechnology, food, pharmaceuticals, and biofuels.
Effects of normalizing and tempering temperature on the bainite microstructure and properties of low alloy fire-resistant steel bars
Authors: Zheng Zhichao , Ren Jie , Zhang Li , Guan Lanfang , Liu Chengzhi , Liu Yanlian , Cheng Shengwei , Su Zexing , Yang Fei
Published: June 2024

Different combinations of normalizing and tempering were carried out to optimize the microstructure and enhance the high-temperature mechanical properties of HRB400FR fire-resistant steel bars. The results showed that with the increasing of the tempering temperature from 400 to 600°C, the steel bar’s hardness decreases linearly, mainly due to the formation of quasi-polygon ferrite and granular bainite. Besides, the reduced width and the dissolution of the lath bainite also undermine the performance of the tempered steel bars. The highest Vickers hardness of 380 HV is achieved when the steel is normalized at 950°C and then tempered at 400°C, mainly due to precipitation strengthening and bainite strengthening. The hardness of the test steel tempered at 600°C gives the lowest value, only 230 HV since the least amount of bainite is obtained. When the tempering temperature reaches 650°C, the hardness rises to 260 HV due to the formation of the lath bainite. The emergence of needle bainite generally reduces the matrix grain size, and the appearance of lath martensite refines the precipitated carbides.
Der Mensch in der intelligenten Fabrik
Authors: Lück Matthias , Hornung Tim , Teklezgi Joel
Published: June 2024

The seamless merging of the physical and digital worlds, has led to an unprecedented increase in the speed at which automation can be introduced into production. can be introduced. Smart manufacturing systems will, at a fundamental level, enable the use of artificial intelligence (AI) through machine learning (ML). This involves the alignment of information flows through suitable interfaces to humans is essential. is indispensable. This human-centered approach is referred to as Industry 5.0 (I5.0) or the human-centered approach (HCA) [1, 2]. The prioritization of people can be achieved prioritization can be achieved by placing the process-related interests of people at the at the center of production monitoring and relying on technologies that help employees by developing knowledge and skills, initiate optimizations.
Exoskelette in der Intralogistik
Authors: Pupkes Birte , Hoppe Nils , Petzoldt Christoph , Freitag Michael
Published: June 2024

Due to the high physical demands of many manual work activities in intralogistics and the economic consequences of the resulting sickness-related absences, exoskeletons are becoming increasingly important. By physically relieving and actively supporting employees, work tasks can be made more ergonomic and the challenges mentioned can be counteracted. However, the variety of exoskeletons available on the market presents companies with major challenges when it comes to planning and selecting suitable systems. This article therefore presents an exoskeleton morphology that illustrates the different types of exoskeletons and enables the classification of suitable systems. Based on this, the results of a market analysis are visualized. Secondly, a method for the systematic and application-oriented selection of exoskeletons in intralogistics is presented. This method maps the application-specific requirements and ergonomic needs to the morphological characteristics in order to recommend suitable exoskeletons. The method is applied and validated using two intralogistics application examples, container unloading and palletizing.
Anreize für die Rückführung von Produkten in der Kreislaufwirtschaft
Authors: Lang Enno , Fischer Marcel , Metternich Joachim
Published: June 2024

The circular economy is seen as an outstanding opportunity to address the global challenges of climate change and resource scarcity. This is achieved by narrowing, extending and ultimately closing resource cycles. When implementing a circular economy, however, a major challenge is to return a company‘s products after their utilisation phases in order to initiate value-preserving or valueenhancing activities. This article analyses and structures incentives for facilitating the retrieval of products using practical examples and expert workshops.
Eye-Tracking-basierte Analyse des menschlichen Verhaltens
Authors: Naussedat Rolf , Gunnemann Lisa , Potthoff Leonie
Published: June 2024

Over the last 10 years, production systems have been shaped by Industry 4.0, which drives digitalisation and networking in real time. Industry 5.0, on the other hand, focuses on human-centred technologies that support employees and enhance their skills. Personalisation plays a major role here, especially in manual assembly and testing workstations. The challenge is to adapt workstations individually without compromising standardisation. Eye tracking is used to investigate influencing factors at the workplace and analyse the data using software. This research forms the basis for a concept for the personalisation of manual workstations.
Regressionsbasierte Ermittlung von Ausführungszeiten in Mensch-Roboter-Kollaboration
Authors: Jansing Steffen , Jung Lena , Hoffmann Florian , Deuse Jochen
Published: June 2024

The intensifying competitive pressures in manufacturing companies, combined with the expanding array of product variants, are propelling the integration of human-robot collaboration in operational frameworks. Effectively planning assembly processes demands particularly streamlined methods for assessing execution times, especially in the initial planning phases. While predetermined motion time systems are designed for human tasks, this contribution puts forth an approach for the time-economic analysis of robot movements without resorting to simulation.
Prognosebasierte Kompetenzbewertung für einen nachhaltigen Aufbau von Schlüsselkompetenzen
Authors: Jansing Steffen , Schallow Julian , Schulte-Uebbing Nele , Danhausen Paula , Gudergan Gerhard , Deuse Jochen
Published: June 2024

Today‘s economy is undergoing fundamental change with regard to digitalization and automation. Constantly growing market complexity and dynamics as well as the demographic change are shifting the skills required of employees and demanding a high level of flexibility by companies. In addition to the appropriate deployment of employees, there is a need to identify the skills required in the future at an early stage.
Agricultural Decisions and Disagreements in Stalinist Hungary, 1948–1953
Authors: Luka Dániel
Published: June 2024

The purpose of the study. The aim of this study is to explore the inner repression in the state and party apparatus regarding rural affairs, the emerging dissent among the cadres and the conflicts of Stalinist style collectivization related to agricultural decision-making and its implementation. The main research period is the height of party state terror when the symptoms of malfunction of planned economy surfaced more intensively between 1951 and mid-1953. Applied methods. Qualitative analysis was conducted on archival sources, which consists of party organs’ resolutions and documents as well as of reports, minutes and records of the Ministry of Agriculture in particular. Outcomes. The party leadership’s reaction to the challenges and crisis was constant purge, but even persecution of the “enemies” of the state had to be limited. The study highlights that the agricultural apparatus did not implement unreasonable plans without any resistance from 1948 up until mid-1953. It does mean that the communist agricultural policy cannot be seen as a straight line. On the one hand, the failing collectivization drive forced the top brass to reconsider policy; on the other hand, the growing dissatisfaction and disagreement could play a significant role in the process.
Archontologie der Offizierkorps des Komitats Baranya (1790–1849)
Authors: Pintér Tamás
Published: June 2024

The purpose of the article. The main aim of this paper is to present the archontology of the officer corps of Baranya county. The study does not aim to provide a comprehensive overview of archontological research in the Hungarian counties, but the author merely attempts to place the archontology of Baranya County in the context of the other counties. Applied methods. As part of my work, I examined the composition of the county assembly from the assembly of April 1790 until the introduction of the new administrative system in 1850. The primary sources of my research were archival materials. First, I examined the minutes of the county assembly to determine the dates of the restorations. After the restorations, I also searched the county assembly protocols for officials who died or were appointed between the restorations. Using the death registers collected in the parishes, I determined exact date of death of officials and the appointment of the replacement. In cases where neither the records nor the registers were available, I consulted other archival sources, such as the records of the Insurgentions and families. Results. Archontologies can be analyzed scientifically in many areas. In my work, I only carried out basic statistical analyses. I examined and presented the 185 people who held officer positions in Baranya between 1790 and 1849. This list can be found at the end of the study. At the end of my work, I examined how the officers entered and left the county administration.
Leasehold Payments from the Perspective of the Hungarian Chamber of Agriculture
Authors: Fekete Kristóf
Published: June 2024

In this study, the author presents and analyses the proportionality examination of leasehold contracts in the light of recent legislative changes from the viewpoint of the Hungarian Chamber of Agriculture, in this framework, the paper also deals with the practice of the agricultural administrative bodies. Starting from the relevant constitutional and statutory provisions, the study describes, through pragmatic examples, the obligations and possibilities of the Hungarian Chamber of Agriculture regarding the disproportionality of leasehold payments, as well as its emerging practice. The study concludes that the Hungarian Chamber of Agriculture is real support for agricultural administrative bodies in their procedures for determining the disproportionality of leasehold payments and that their decisions can reflect the value and interests of agriculture, as enshrined in law.
Messages of Personal Identity Attempt in Foreign Criminal Rules
Authors: Fenyvesi Csaba
Published: June 2024

Research worldwide and in our country (Hungary) have revealed that false personal identities play a prominent role in “justizmord” cases. That is why it is worthwhile having a closer look at identity rules and methodologies of other countries in this respect as well. In this study, the author examines the Slovenian, Austrian, Swiss, Serbian, Croatian, and distant (but, as it turns out, much the same) Turkish norms, all embedded in the continental legal system just like the Hungarian ones. Based on the legal details and implementation recommendations there, the researcher formulates at the end of his study the lessons learned from the models, the legal and forensic development opportunities available to us, the conclusions for efficiency and fairness, and the current and future messages to legislators and practitioners.
The Principle of Protecting the Best Interests of the Child in Vietnamese Divorce Law
Authors: Huỳnh Thị Trúc Giang
Published: June 2024

Divorce can have adverse effects on children in many ways, which has been extensively studied and demonstrated in scientific literatureworldwide. Therefore, policymakers around the world, including Vietnam, have incorporated the principle of protecting the best interests of the child into their approach to addressing issues related to children during the process of their parents' divorce.This incorporation aims to reduce the negative impact of divorce on children and create a favorable environment for their comprehensive development. This article approaches the subject from the perspective of children's rights. Its objective is to introduce the application of the principle of safeguarding the best interests of children in the enactment and enforcement of divorce laws in Vietnam. It focuses on aspects such as determining the custodial parent, child visitation, child support, and changing the custodial parent
Muammâyî Ahmed Çelebi’nin Muammaları
Authors: Akboğa Songül
Published: June 2024

Klasik Türk edebiyatında ilk örneklerini 15. yüzyılda veren muamma, 16. yüzyılda Edirneli Emrî Çelebi (öl. 1575) ile beraber rağbet edilen bir tür hâline gelmiştir. Emrî, muamma konusunda tezkire yazarları ve edebiyat otoritelerince bu türün en velut ve başarılı şairi olarak kabul edilmekle birlikte Anadolu coğrafyasında bu türde manzumeler kaleme almış başka isimler de mevcuttur. Bunlardan biri, kaynaklarda kendisiyle ilgili çok fazla bilgi bulunmayan ve şu ana kadar tespit edebildiğimiz 297 muammasıyla edebiyat tarihleri arasındaki yerini almayı hak ettiğini düşündüğümüz Muammâyî Ahmed Çelebi’dir (öl.1606/1607).
Muammâyî Ahmed Çelebi’nin kaleme almış olduğu muammaların sayısı; özellikle Emrî’nin muammalarının sayısı ile (600 küsür) kıyaslandığında hatırı sayılır bir yekûn oluşturmaktadır. Şairin aynı zamanda bu türün en başarılı ismi olarak kabul edilen Emrî’nin muammalarını şerh etmiş, dolayısıyla muammaya olan vukufu ve hâkimiyetini ispatlamış bir şârih olması, Muammâyî Ahmed Çelebi’nin muammalarının literatüre kazandırılmasını önemli kılmaktadır.
Bu çalışmada Muammâyî Ahmed Çelebi’nin muammaları, tespit edilen beş yazmadan derlenmiş ve nüsha farkları dipnotta belirtilerek ortaya konulmuştur. Bunun sonucunda Muammâyî Ahmed Çelebi’ye ait 87’si Farsça, 210 tanesi Türkçe olmak üzere 297 muamma tespit edilmiştir.
El estudio del proceso de enseñanza y aprendizaje del pretérito perfeito composto del portugués en hispanohablantes: una revisión sistematizada de la bibliografía
Authors: Alonso Rey Rocio
Published: June 2024

Los estudios en el campo del portugués para hispanohablantes, a partir de las características particulares observadas en el proceso de aprendizaje, han planteado una serie de orientaciones metodológicas específicas para la enseñanza a este grupo de hablantes. Dichas orientaciones no siempre han encontrado un acomodo fácil en el aula, usualmente por ser demasiado generales y poco explícitas para su aplicación. Con el fin de contribuir a la elaboración de propuestas didácticas más específicas y fundamentadas, este trabajo presenta una revisión y mapeo de los trabajos que estudian el proceso de enseñanza y aprendizaje de un aspecto divergente concreto, el pretérito perfeito composto, para determinar cómo se describe su funcionamiento en el marco del portugués para hablantes de español y qué propuestas se hacen para su tratamiento en el aula, presentando el estado actual y las lagunas en la investigación de este aspecto.
Problematization іn the plane of the structure of the scientific subject (Lecture materials on the topic)
Authors: Kozlyk Ihor
Published: June 2024

The scientific-methodological article deals with the analytically systematized materials on the topic «Structure of a scientific subject» from the educational subject «Modern Literary Epistemology». Aim. To present students with adapted material for independent study of the topic. Methods. Analytical systematization and educational and methodical adaptation. Results. A variant of actualization of the traditional literary methodology in the projection on the principles of the system-thought-activity approach is presented. Research novelty. For the first time, a literary study of the problematization phenomenon is presented with a sequential consideration of the developments in the general methodology of H.P. Shchedrovitsky. Practical meaning. The article can be used to prepare lectures, seminar classes and for independent work in “Modern Literary Epistemology”.
Mykhailo Hrushevsky and His Francophonic «Anthologie de la littérature ukrainienne» (1921) in Belgian and French Publications of the 20th and 21stcenturies (in Ukrainian) 7-15
Authors: Kravets Yarema
Published: June 2024

Mykhailo Hrushevsky’s presence in French culture dates back to the beginning of the 20th century (a course of lectures in Paris, a review of É. Verhaeren’s drama, a 1912 Paris edition, etc.). Scholar’s most outstanding work in the context of Ukrainian-Francophone literary relations is his «Anthologie de la literature ukrainienne» (1921), which helped Francophone researchers learn about the literary heritage of Ukraine from ancient times to the 19th century. The main thesis of the article is the importance of this anthology in further acquaintance of the French speaking world with Ukrainian literature. The preface to this book written by the French linguist professor Antoine Meillet of College de France was important as it emphasized such an significant fact about the publication as «literature in Ukrainian not well known in other countries». M. Hrushevsky explained that it was only the first step of Ukrainian sociological institute which started its work on creation of the anthology of Ukrainian literature of later period. Materials from the edition of Ukrainian Sociological Institute were partly used in 1928 by the editorship of the Belgian-French magazine «La Nervie», being completed by some other samples of Ukrainian literature of the second half of the 19th century and the first two decades of the 20thcentury. Another fact that testifies about the importance ofHrushevsky’s anthology is that the outstanding French scholar and literary critic Roger Tisserand, the author of numerous encyclopedia articles about Ukrainian writers and the work «Life of a nation. Ukraine», referred to it more than once using some samples of Ukrainian poetry. Two excerpts from Mykhailo Hrushevsky’s edition («Galician–Volhynian Chronicle» (fragment) and «Praise to St. Volodymyr») were reprinted in Vol. 4a (1993) by the compilers of Belgian encyclopaedia «Patrimoine littéraireeuropéen» (12 vols.). A separate chapter about Mykhailo Hrushevsky and an excerpt from his foreword to the «Anthologie…» were included into Sarcelles anthology of Ukrainian literature (2004) by literary scholar Arkady Zhukovsky. The scholar described extensively Mykhailo Hrushevsky with special focus on his scholarly-research work, teaching and organization of academic life.The literary critic illustrated life and creative activity of the scholar by extracts from the preface to «Anthologie de la littérature ukrainienne…» and gave a short explanation of the issues, raised by Mykhailo Hrushevsky in his subsequent works. The material in the article about the resonance of  M. Hrushevsky’s French anthology in the French speaking milieu testifies to the presence of the outstanding scholar, historian and literary critic in European culture. Such works as André Mazon’s memorable article in the Slavic journal «Le Monde Slave» (V. 12, № 1–2, 1935) and A. Joukovsky’s French language research «Mykhailo Hrouchevskyi. Sa vie et son œuvre. Paris, 1997» are of great interest.
Church singing of Mari region in the Soviet period (1917‒1941)
Authors: Simakova Albina
Published: June 2024

This article studies the history of church singing in Mari Region (1917‒1941). This study allows us to solve a number of important problems in the history of Mari region. These include the church singing culture, the position of the Russian Orthodox Church in the Soviet period, the activities of the Mari intelligentsia, &c. The art of church singing in Mari region was of great importance; it infl uenced not only the processes of christianisation and education of the indigenous Mari population, but also the culture, mentality and the very quality of life of local residents. The end of the 19th and the beginning of the 20th centuries were fruitful in this regard. At that time, a foundation was formed, which, during the years of Soviet persecution of the Church, revealed new martyrs and confessors of the Orthodox faith among local clergy, monks, laypeople, as well as choir masters, sextons, and choir members. The study of the mentioned topic allows us to state that the church-singing culture of the Mari land, as well as of other regions of the country, was in a very diffi cult situation. The traditions of church singing, laid down in the pre-revolution period, were virtually interrupted during these years. Many people had to go through hardship associated with the antireligious persecution. Very few were able to endure all the trials and remain to work in the “field of Christ” or at least remain in the Church. Nevertheless, the culture of church singing, ousted from the Church, continued in many secular choirs. Masters of church-singing art now worked in various choirs. In such diffi cult conditions, church singing in many churches remained for more than a dozen years, almost until the end of the 20th century.
Features of the Slavnik notation “The meaning is cleansed” and «Like a crown of light” in the Studio Era
Authors: Trubitsina Yuliya
Published: June 2024

The oldest slavs from the Theotokos Services, which have Byzantine origin, are included early enough in the repertoire of the Mina Stichera of the Studio era. In the notated manuscripts of this period, a strong relationship is established between two of the three Mother of God feasts – the Position of the Belt and the Intercession of the Most Holy Theotokos, whose chants have been included in the repertoire of the Intercession service since the XV century. This article is devoted to the study of the notated lists of hymns "Like the crown of the Most Holy" and "The Meaning is cleansed" during the period of dissemination of the Studio Charter. The main sources of research were the Mine Stichera of the Studio era from the collections of the Russian National Library (RNB), the Library of the Academy of Sciences (BAN), the Russian State Library (RSE), the Russian State Archive of Ancient Acts (RGADA). The author examines in detail the features of notation, the "main editions" of the chants served as a reference material. Due to the lack of the possibility of reconstructing the original source, and even more so of deciphering the notes of the Studio era, the main method of analysis is the comparison of melodic-graphic formulas. As a result of the analysis, the obvious relationship between the sources of both earlier and later ones is clearly demonstrated. For convenience, textual scores were compiled, fixing the "main edition" of each chant in chronological sequence (from earlier lists to later ones).
The language of the Pentateuch translation in the Eupatorian printed edition from 1841
Authors: Işık Murat
Published: June 2024

This paper provides an analysis of the language employed in the Pentateuch section of the Eupatorian print (Gözleve) edition, a comprehensive translation of the Old Testament into the Karaim language published in 1841. The objective of the study is to identify the specific Crimean Karaim variety employed in the translation through an examination of phonological, morphological, and lexical features. The analysis reveals that the translation displays features of both Crimean Kipchak Karaim and Crimean Turkish Karaim, and that the characteristics vary depending on the specific books and chapters of the edition.
Hachan Markas Lavrinovičius’ commitment to the Karaim language Trakai dialect preservation and revitalisation
Authors: Lavrinovič Diana
Published: June 2024

The paper introduces Markas Lavrinovičius’ most significant jobs in the Karaim cultural heritage preservation and revitalisation. Markas Lavrinovičius (1938–2011) was a Doctor of Science, Lithuanian Karaims’ Hachan, and the Chairman of the Lithuanian Karaims’ Religious Community. He was an active Karaim community member who made an important contribution to the language research and its revival. He described Karaim customs and traditions, compiled Karaim literary heritage, and prepared it for publication; he also described the Biblical stories in the Karaim language, translated relative Turkic-speaking nations’ folk fairy tales into Karaim, and compiled and computerised the Russian-Karaim dictionary. In addition, the article contains a review of the Karaim language coursebook titled 100 karaj tiliniń üriatiuviu. Troch karaj sioziu ([100 Karaim language lessons. Trakai dialect]) – one of his most significant works, containing a thorough research on the Karaim grammar, conducted by Markas Lavrinovičius and Diana Lavrinovič. Despite being surrounded by non-Turkic languages for 625 years, the Karaim language Trakai dialect has managed to preserve its purity and remain untouched throughout the centuries. Unfortunately, it currently faces the threat of extinction. Therefore, teaching the mother tongue was Markas Lavrinovičius’ ultimate goal.
Application of activity and time-based costs in the determination of artisanal açaí wine costs
Authors: Nunes Fernandes José Luiz
Published: June 2024

By identifying previous works in which the scouts price the açaí product based on the production costs calculated by them, this result lacks greater accuracy and knowledge about the identification and selection of costs. This is what established in the present work, the objective of measuring the cost of artisanal açaí wine through Activity and Time Based Costing. The research carried out and based on an exploratory methodology added by collecting primary data with theoretical-empirical analysis. As a result, it identified that the costs have two behaviors, one in the Amazonian summer or less rainy phase and the other in the winter of the same region when there is a higher incidence of rain. In the Amazon summer, it found that when the Activity and Time Based Costing is adopted, the transaction costs additional to the transformation costs generate the production of 1 liter of açaí for R$ 7.57. In the winter period, when the same costing method is used, the transaction costs added to the transformation costs generate the production of 1 liter of açaí for R$ 10.24.
Timed fault-tolerant supervisory control
Authors: Leduc Ryan J , Mulahuwaish Aos , Alsuwaidan Amal
Published: June 2024

In Mulahuwaish,1–4 we investigated the problem of fault tolerance in the framework of untimed discrete-event systems (DES). This approach is different from the typical fault-tolerant methodology as the approach does not rely on detecting faults and switching to a new supervisor; it requires a supervisor to work correctly under normal and fault conditions. This is a passive approach that relies upon inherent redundancy in the system being controlled. In this paper we extend the work of Mulahuwaish1–4 to the timed DES (TDES) setting. We introduce our setting, and then provide a set of timed fault tolerant definitions designed to capture different types of fault scenarios and to ensure that our system remains controllable in each scenario. As the nonblocking property is the same for timed and untimed DES, the untimed fault-tolerant nonblocking properties and algorithms from Mulahuwaish1–4 can also be used in the timed setting without any changes. We then present algorithms to verify these properties followed by complexity analyses and correctness proofs of the algorithms. An example is then provided to illustrate our approach.
Effect of angiotensin II receptor blockade combined with a thiazide diuretic on plasma aldosterone escape in healthy subjects
Authors: Burnier Michel , Maillard Marc , Vogt Bruno , Wuerzner Gregoire
Published: June 2024

Objective: The chronic administration of ARBs is associated with an incomplete ALDO suppression suggesting either a partial blockade of adrenal angiotensin AT1 receptors or a breakthrough phenomenon. We have investigated the adrenal response to exogenous Ang II in healthy subjects receiving an ARB alone or in association with a thiazide diuretic. Methods: Thirty subjects participated in this randomised, controlled, single-blind study. The effect of a 1 h infusion of Ang II (3 ng/kg/min) on plasma ALDO levels were investigated in each volunteer before and after a 1-week single-blind administration of either irbesartan 300 mg alone or in association with hydrochlorothiazide (HCTZ) 12.5 or 25 mg. After one week washout period, volunteers were switched to olmesartan 20mg/HCTZ 25 mg or valsartan 160/HCTZ 25 mg or losartan 100/HCTZ 25mg for another week. Results: Compared to pre-treatment values and to irbesartan alone, trough plasma ALDO values were higher in subjects receiving Irb300/12.5, and were significantly increased with Irb300/25 (to 4.9±1.8 and 7.5±1.2 ng/dl respectively, p<0.05). In participants receiving Olm20/25, Vals160/25 and Los100/25, trough ALDO were also significantly elevated. Before any treatment, exogenous Ang II increased plasma ALDO acutely from 3.6±0.7 to 13.2±1.3 ng/dl. With Irb300, the ALDO response to Ang II was blunted by 50-60% independently of the presence of HCTZ (p<0.05). The ALDO response to Ang II was also significantly blunted by about 50-60% with Olm20/25 and Vals160/25, but not with Los100/25. Conclusion: These results demonstrate that recommended doses of most ARBs only partially block the adrenal response to exogenous Ang II when associated with a thiazide diuretic. The ARB-thiazide association accentuates the aldosterone escape thus further justifying the use of mineralocorticoid antagonists in some clinical circumstances such as resistant hypertension or hypertension with severe end organ damage.
Cardiovascular disease prediction with machine learning techniques
Authors: Petreska Anita
Published: June 2024

Cardiovascular disease (CVD) remains the leading cause of death globally. In search of advanced techniques for early detection of CVD, recent research has increasingly focused on using machine learning (ML) methods to improve the accuracy and timeliness of diagnosis. A multifactorial machine learning approach offers a comprehensive solution for cardiovascular disease detection, using vast and diverse datasets to develop predictive models that outperform traditional methods. This paper provides a comprehensive examination of various machine learning approaches and their application in the early detection of cardiovascular abnormalities, with special emphasis on their effectiveness compared to traditional diagnostic methods. The research methodology involves the implementation of several ML models trained and tested using large datasets that provide analysis covering various demographic parameters, lifestyle parameters and health status parameters. Key findings show that ML models significantly outperform traditional statistical methods in detecting early signs of CVD. The superior performance of ML models represents a promising tool for healthcare professionals, potentially leading to better strategies for preventive care and reduction of CVD-related mortality. The ongoing development and refinement of these technologies, along with improvements in data collection and interoperability between healthcare systems, will be critical to realizing their full potential in the clinical setting.
Everything, everywhere, all at once
Authors: Sarnecki John
Published: June 2024

The development and early distribution of the COVID-19 vaccine was both a singular achievement and missed opportunity. In this paper, I argue that the consensus regarding the goals of an effective and morally responsible vaccine distribution program were often eschewed in favor of a reversion to the problematic pre-pandemic healthcare distribution practices. I examine the goals of vaccine planning in terms of the public health, economic and social impacts of a distribution plan against the “first come, first served” strategies that were ultimately employed. I maintain that the failure to implement a coherent top- -down vaccine policy resulted in a proliferation of vaccine distribution programs that undermined efforts to combat the virus while also increasing pre-existing inequities in the healthcare system. The distribution of the vaccine according to a phased rollout strategy for individual groups often limited access to the vaccine for those most likely to suffer the worst outcomes of the disease. Future pandemic planning must learn from these outcomes and employ new technologies to limit the contagion and target at-risk groups most effectively.
Enhancing Kuwaiti Teachers’ Technology-Assisted Mathematics Teaching Practices
Authors: Soliman Mamdouh , Lavicza Zsolt , Prodromou Theodosia , Al-Kandari Maryam , Houghton Tony
Published: June 2024

This paper outlines results of the first cycle of a mathematics education project in Kuwait aimed to integrate technology into teaching and learning in Kuwaiti schools. The project design and methods are based on two previous studies carried out in Cambridge, UK and the Geomatech
project in Hungary. Studies showed that adequate preparation of teachers is necessary to have impact on students learning with technology. In the first cycle of this project we carried out an extensive teacher training to introduce practices and resources with the GeoGebra application and
materials developed in the Geomatech project. The research design was based on Design Experimental and Community of Practice approaches involving the close collaboration of teachers and researchers to jointly develop resources and pedagogies. In this paper, we will offer an outline of the
study design and the frameworks based on previous projects as well as highlight some initial findings from interviews conducted in the first cycle of the project.
Vadovo lyderiavimo stiliaus ir kontekstinių kintamųjų sąsajos
Authors: Nedzinskaitė-Mačiūnienė Rasa , Stasiūnaitienė Eglė , Česnavičienė Juratė
Published: June 2024

Šiame straipsnyje remiantis teorinėmis įžvalgomis ir atliktu kiekybiniu tyrimu su skirtingo tipo ugdymo įstaigų vadovais, nagrinėjama, kaip įvairūs kontekstiniai kintamieji (vadybinio darbo stažas, vadovaujamo kolektyvo dydis, ugdymo įstaigos dydis ir vietovė bei kt.) yra susiję su ugdymo įstaigų vadovų lyderystės stiliumi (padalytoji, adaptyvioji, bendradarbiaujanti). Tyrimo rezultatai rodo, kad prisiimamas vadovo lyderystės stilius nežymiai priklauso nuo kontekstinių veiksnių.
Preschool Teachers’ Application of Visual Arts in Kindergartens
Authors: Rochovská Ivana , Brozmanová Monika
Published: June 2024

Research focuses on the application of visual arts in preschool education from the perspective of kindergarten teachers. The research instrument was a questionnaire constructed by the authors. Based on the self-reflection of kindergarten teachers, opportunities to acquire knowledge in visual arts were found to predict kindergarten teachers' attitudes toward visual arts. The attitude of kindergarten teachers toward the visual arts predicts the use of visual arts in preschool education.
Ideologia de gênero e crise da democracia na América Latina em debates legislativos no Brasil e no Uruguai
Authors: Rezende Daniela Leandro , Elias Maria Lígia Ganacim Granado
Published: June 2024

Resumo: Este artigo apresenta uma análise comparativa dos movimentos antigênero na América Latina, com foco no Brasil e no Uruguai, e tem o objetivo de investigar como esses se relacionam com processos de desdemocratização. Metodologicamente, foram analisados, a partir da técnica de análise de conteúdo temática (Bardin, 2016), discursos proferidos em câmaras legislativas dos dois países sobre a denominada “ideologia de gênero” na década de 2010. Como resultados, identifica-se que a atuação via poder legislativo tem sido uma estratégia compartilhada dos movimentos antigênero, especialmente com o objetivo de fundar e/ou fortalecer as bases religiosas para avançar nas agendas conservadoras e restringir direitos. No entanto, o sucesso dessa estratégia varia de país para país. Observam-se semelhanças entre os casos brasileiro e uruguaio, mas os movimentos são mais robustos no Brasil. Este trabalho junta-se a uma série de debates que identificam nas questões de gênero um eixo estruturante do processo de desdemocratização pelo qual passam distintas democracias contemporâneas e aponta para o fato de que o posicionamento daqueles que são contrários à ideologia de gênero não se restringe a um debate no campo dos costumes, mas, principalmente, estabelece-se no campo da disputa em torno dos valores democráticos e do próprio sentido da democracia.
Evaluation basal lipid metabolism components and adiposity in trained Arabian horses for Endurance and Racing
Authors: Siqueira Renata Farinelli de , Silva Bianca Ozi , Fernandes Mônica Lente , Fernandes Wilson Roberto
Published: June 2024

ABSTRACT: Endurance and flat race are entirely different efforts and thus require completely different organism adaptations to achieve the performance. This study aimed to examine the difference in basal lipid metabolism in Arabian horses undergoing different training regimens for endurance and race and possible gender differences. The study enrolled sixty male and female’ Arabian horses; thirty were trained for race, and thirty were trained for 80 km endurance races. The analyses included body condition score, body weight, body mass index, % body fat, and blood collected to determine triglycerides, total cholesterol, low-density proteins, high-density proteins, and non-esterified fatty acids. Ultrasonography was used to measure the thickness of the subcutaneous fat layer in the longissimus dorsi muscle, as well as the thickness of the rump fat and the cross-section of the gluteus medius muscle. This study showed that lipid profile is more influenced by type of exercise than by gender, being more efficient on endurance horses.
Influenza A virus surveillance in domestic pigs in Kazakhstan 2018-2021
Authors: Lukmanova Galina , Klivleyeva Nailya , Glebova Tatyana , Ongarbayeva Nuray , Shamenova Mira , Saktaganov Nurbol , Baimukhametova Assem , Baiseiit Sagadat , Ismagulova Dariya , Ismailov Eldar , Baisseyev Galikhan , Mustafin Muafik
Published: June 2024

ABSTRACT: This study described the results of a surveillance program monitoring circulation of influenza A viruses among domestic pigs (Sus domesticus) in Kazakhstan during 2018-2021. PCR data derived from 2,513 samples (nasopharyngeal swabs) collected from swine on large pig complexes and peasant farms located in different regions of Kazakhstan revealed that about 5% of samples were positive for influenza A virus RNA. This result suggested low levels of influenza A virus circulation in Kazakhstan. Subtyping of a set of samples revealed that the main strains circulating in 2018-2019 were A/H1N1 and A/H3N2.Surveillance conducted in 2020-2021 identified only A/H1N1 viruses in swine. The PCR data were confirmed by isolation of six strains: five influenza A/H1N1 viruses and one A/H3N2 virus.
Disability prevention, detection and assistance in primary health care services in the state of São Paulo, Brazil
Authors: Zarili Thais Fernanda Tortorelli , Castanheira Elen Rose Lodeiro , Nunes Luceime Olivia , Mendonça Carolina Siqueira , Couto Caroline Eliane , Rossato Sinara Laurini , Nemes Maria Ines Baptistella
Published: June 2024

Abstract The objective of this study was to assess the performance of primary health care (PHC) services for disability prevention, detection and assistance in the state of São Paulo. The study included 2739 health services, from 514 municipalities. 128 organizational quality indicators of the QualiAB instrument referring to the evaluative dimension “Attention to disability in primary health care services”. The association of health care performance score of each domain with independent variables, health assessment, and support network were tested using of multiple linear regression. The performance percentage was 61.6% for all domains, 73.6% for structure (inputs and human resources), 68.7% for qualification of prenatal care, 56.1% for qualification of child health care, 55.8% for prevention of disabilities related to chronic conditions, and 53.9% for attention to people with disabilities and caregivers. There was a significant association with variables related to the type of service and participation in service evaluations. PHC services still perform incipient actions for the prevention, surveillance and diagnosis of disabilities as well as for comprehensive care for people with disabilities.
Desempenho da atenção primária à saúde no estado de São Paulo, Brasil, no período de 2010-2019
Authors: Sala Arnaldo , Luppi Carla Gianna , Wagner Gabriela Arantes , Pinheiro Junior Raimundo Valdemy Borges , Carneiro Junior Nivaldo
Published: June 2024

Resumo O artigo apresenta uma análise do desempenho da APS no estado de São Paulo na última década, em contexto de crise econômica e retração dos investimentos em saúde. Utilizaram-se indicadores de desempenho, determinantes em saúde e sistema de saúde, em série temporal (2010 a 2019), a partir de matriz conceitual adaptada. Foram calculadas variações percentuais anuais (VPA) de cada indicador em modelo log-linear. Os indicadores de desempenho apresentaram, no geral, evolução favorável; no entanto, ocorreu piora em indicadores relacionados à qualidade do cuidado (sífilis congênita, partos cesáreos e rastreamento de câncer de colo uterino). Verificou-se, ainda, um potencial aumento das demandas ao SUS (envelhecimento da população e redução da cobertura da saúde suplementar) e aumento das despesas em saúde em contexto de redução do PIB per capita.
Pests, development and inequalities
Authors: Santana José Francisco Nogueira Paranaguá de , Silva José Agenor Alvares da , Penna Gerson Oliveira , Morais Rafael Santos Gonçalves de Assis , Nogueira Roberto Passos , Lopes Cecília de Almeida , Carmo Eduardo Hage , Amorim Manoel de Araújo , Campos Roberta de Freitas
Published: June 2024

Abstract This article discusses questions concerning the future of humanity in the face of threats to the health of populations, whose impact has been exacerbated in the course of inequalities in all parts of the world, pari passu with global development in the hegemonized model since last century. The COVID-19 pandemic is a good example that illustrates this dissonance between development and inequalities. Questions were formulated to be debated about the construction of the future of world society, based on the understanding of the evolutionary character of life on the planet vis-à-vis the evils that affect large contingents of the population and represent powerful risks for this evolutionary process. These questions call attention to the discussion around social participation in the definition and control of public policies, as opposed to the hegemony of private interests in the formulation and execution of these policies, both in the scenarios of each country and in the international context.
Community experiences and strategies of risk management within chemsex practices: a qualitative study
Authors: Cano-Ruiz Oscar , Íñiguez-Rueda Lupicinio
Published: June 2024

Abstract The rise in the study of sexualised drug use among gay, bisexual and other men who have sex with men (MSM), known as chemsex, has generated a multiplicity of data that contribute to its problematisation as a public health issue through the link with HIV and addictions. The study of these practices, from a biomedical paradigm, has focused on risk and has contributed to its reduction as a unique and quantifiable phenomenon. This study aims to explore the experience of risk in the course of the practices, to find out what management strategies they employ in the face of risk and how they are generated. Semi-structured interviews were conducted with five chemsex practitioners in the Metropolitan Area of Barcelona and, subsequently, a thematic analysis was applied. The findings show how these men detect, assume and confront the risks present in these practices, where the type of relationships that take place and the social circle available to them are relevant. This study also highlights the creation of strategies based on experience and how the transmission of this knowledge among participants facilitates decision-making and risk management.
Breast cancer cultural representations: a scoping review
Authors: Maroun Pedro Senise , Gomes Romeu , Silva Adriano da
Published: June 2024

Abstract This article aims to map the global scientific production on social or cultural representations and breast cancer in Public Health and discuss how it is presented in the literature. We conducted a scoping review guided by the question: “How are cultural or social representations in the context of breast cancer described in the global scientific Public Health production?”. We searched for works in five scientific literature sources and included 45 studies. The analytical process followed the content analysis technique in the thematic modality. The analyzed collection can be thematized into the following categories: (1) Compromised body image and interactions, (2) Spirituality, (3) Loss of control over life, (4) Going on with life, and (5) Association with ethnic-racial issues. Despite advances in biomedicine, we observed that representations of breast cancer still have metaphors associated with cancer in the last century. We conclude that, among other aspects, care for women with breast cancer cannot be guided only by biomedical and epidemiological approaches since this disease is traversed by knowledge that competes with these approaches.
Reflexões sobre práxis investigativa cogestora em contexto de emergência sanitária
Authors: Gutiérrez Adriana Coser , Campos Gastão Wagner de Sousa , Jandoso Bruna , Cunha Marcela Silva da , Mattos Mauricio Pereira de , Silva Rafaela de Oliveira Lopes da
Published: June 2024

Resumo O artigo trata do interesse do campo científico em sistematizar a práxis investigativa cogestora em cenário de emergência sanitária a partir da análise de uma pesquisa de abordagem qualitativa multicêntrica, valendo-se do referencial da pesquisa-apoio e da análise da hermenêutica critica. Como resultados, identificou-se que a elaboração de um guia-mapa contribuiu como documento norteador, com o objetivo de organizar diferentes técnicas para a preparação e formação dos pesquisadores de campo, também como instrumento de análise dos dados. A formação de pesquisadores para o referencial teórico da pesquisa-apoio, assim como a cogestão e a implicação deles nas diferentes etapas da pesquisa, mostrou-se como diferencial para produção de sujeitos e coletivos com a práxis investigativa, permitindo a troca dialógica dentre coordenadores e pesquisadores e o compartilhamento regular dos resultados. Conclui-se que a forma como a metodologia foi proposta possibilitou a ampliação da capacidade reflexiva e de compreensão sobre a realidade, contribuindo para a formação de pesquisadores como sujeitos ativos e críticos no processo de coleta, análise e discussão dos dados, incentivando a atuação sensível e atenta ao mesmo tempo em que buscou identificar as particularidades de cada contexto.