bluuebunny/crossref_metadata_2025 huggingface dataset:
EVALUATION OF THE OPERATION OF A PUMP USED AS A TURBINE (PAT) UNDER REAL OPERATING CONDITIONS IN A DRINKING WATER TREATMENT STATION (DWTS)
Authors: DÍAZ DORADO ELOY , CIDRAS  PIDRE JOSE , GARRIDO CAMPOS JULIO , CASAL MARTIN , GUITIÁN GUITIÁN FERNANDO , ARIAS BLANCO ALEJANDRO , FERNANDEZ SOÑORA ISABEL , ACEVEDO IGLESIAS DIEGO , FERNANDEZ VILAN ANGEL , Carrillo González Camilo José
Published: June 2023

This paper analyzes the performance under real conditions of an axial flow hydraulic pump used as a turbine (Pump as Turbine or PaT) in a Drinking Water Treatment Station (DWTS).
The DWTS is located at the municipality of Baiona (NW of Spain) and is supplied from a reservoir located at a height of about 50 m above the level of the plant. The existing difference in level at the intake makes it necessary to regulate the flow at the plant inlet by means of a valve, for which, prior to the development of the generation installation, a gate valve was used.
In order to take advantage of the existing difference in level, a 6 kW micro-generation system was put into service using a PaT supported by a butterfly valve for flow regulation. The main reasons for choosing this generation system were the high cost of small turbines for the characteristics of the hydraulic connection of the DWTS and the limited availability of this type of device. The system is in service and being monitored by a SCADA since July 2019 so there is a relevant amount of records that allows analyzing different operating conditions.
In the sizing of a BUTU system it is necessary to estimate the behavior as a turbine since the pump manufacturer only provides data in operation as a pump. There is a large literature proposing methods for estimating the performance of BUTU systems, however, the most widely accepted methods are those validated experimentally, as intended in this article.
Keywords: PaT, renewable generation, micro-hydraulics
INFLUENCE OF SIDE CUTTING EDGE ANGLE ON THE DESIGN OF THE CHIPBREAKER: STUDY OF DYNAMIC AND HIGH FEED TURNING TOOLS IN INCONEL® 718
Authors: AMIGO FRANCISCO JAVIER , FERNANDEZ VALDIVIELSO ASIER , FERNANDEZ DE LUCIO PABLO , PEREIRA NETO OCTAVIO , URBICAIN PELAYO GORKA , CORRALES LACAYO FREDDY , LOPEZ  DE LA CALLE MARCAIDE LUIS NORBERTO
Published: June 2023

Dynamic turning is a recent technology that allows inserts with different cutting edges to be used and the side cutting edge angle to be modified by controlled spindle rotation and synchronised variation of the cutting parameters. This makes it possible to eliminate downtime by reducing tool changes. Chip breaking is a relevant fact in the turning of aeronautical parts, as it allows a higher heat dissipation performance when working with heat-resistant superalloys, materials that degrade inserts rapidly. An initial study has been carried out, using different fixed side cutting edge angles, to test the chipbreaker performance of an experimental dynamic turning insert in order to adapt its design to the machining of aeronautical components, obtaining that, although the cutting performance is good, the chipbreaker does not perform correctly in finishing conditions, and therefore it must be redesigned by reducing its distance to the cutting edge.

Keywords: dynamic turning; high feed; aerospace superalloy; chipbreaker, side cutting edge angle.
Något om läkares tystnadsplikt enligt svensk rätt
Authors: Söderlund Yngve
Published: June 2023

Intet resumé
Narcoanalyse i retspsykiatrien og tavshedspligt.
Authors: Stürup Georg K.
Published: June 2023

Intet resumé
Narkoanalyse og retspsykiatri.
Authors: Strömgren Erik
Published: June 2023

Intet resumé
Dansk, finsk, svensk kronik
Authors: Waaben Knud , Honkasalo Brynolf , Holmberg Carl
Published: June 2023

Intet resumé
Den högre utbildningen av fångvårdstjänstemän i Finland.
Authors: Anttila Inkeri
Published: June 2023

Intet resumé
Dansk og svensk kronik
Authors: Waaben Knud , Holmberg Carl
Published: June 2023

Intet resumé
Reconstruction of a temporal scalp defect without ipsilateral donor vessel possibilities using a local transposition flap and a latissimus dorsi free flap anastomosed to the contralateral side: a case report
Authors: An Jung Kwon , Park Seong Oh , Chang Lan Sook , Kim Youn Hwan , Min Kyunghyun
Published: June 2023

Scalp defects necessitate diverse approaches for successful reconstruction, taking into account factors such as defect size, surrounding tissue, and recipient vessel quality. This case report presents a challenging scenario involving a temporal scalp defect where ipsilateral recipient vessels were unavailable. The defect was effectively reconstructed utilizing a transposition flap and a latissimus dorsi free flap, which was anastomosed to the contralateral recipient vessels. Our report underscores the successful reconstruction of a scalp defect in the absence of ipsilateral recipient vessels, emphasizing the importance of employing appropriate surgical interventions without necessitating vessel grafts.
Penser la notion de frontière dans 'Rêves de femmes' de Fatima Mernissi –de quelques transgressions identitaires, culturelles et génériques–
Authors: Loudiyi Mourad
Published: June 2023

À travers sa représentation traversée par l’idéologie féministe islamique, une perspective sur la frontière et sa poétique dans Rêves de femmes : une enfance au harem de Fatima Mernissi, s’ouvre comme un topos sur ce schème basal à la constitution de l’entité humaine (surtout féminine) comme être situé qui se situe. S’attachant à divers ordres de discours, tantôt croisés, tantôt opposés, sur les champs de la littérature, de la sociologie, de la géographie et de la culture, notre trajectoire va naviguer autour de et dans cette notion complexe qu’est la frontière. L’intérêt de cet article se traduit par l’analyse historico-sociologique qui nous permet ainsi de comprendre qu’au-delà des transgressions des frontières géographiques, culturelles et religieuses, les femmes mernissiennes tentent d’imposer leur place dans divers sphères de l’espace publique.
Hélène Bessette, une artiste sans limites?
Authors: Camus Marianne
Published: June 2023

L’œuvre d’Hélène Bessette (1918-2000) est une expérimentation permanente qui fait fi de toutes les limites. Elle transgresse les règles de bienséance et ne censure aucune opinion. Elle se joue de toutes les règles établies par des siècles de pratique littéraire et éditoriale. La progression narrative et la structuration du texte sont bousculées et réinventées. L’effet théâtral, la comptine, les techniques du slogan et de la publicité, la notion de personnage sont tous détournés dans une indifférence jubilatoire à toutes les contraintes. L’écriture est une prose poétique qui appelle la voix et avance comme une partition. Associations de sons, glissements, ruptures et pauses construisent une respiration, parfois posée, souvent à la limite de l’essoufflement. La graphie et la disposition typographique, hors normes elles aussi, participent, par leur impact visuel fort, de cette œuvre d’art totale que voulait Hélène Bessette.
Faire advenir la complexité pour refaire corps : 'Silence du chœur' de Mohamed Mbougar Sarr, une poétique du franchissement des frontières symboliques
Authors: Brinker Virginie
Published: June 2023

Silence du chœur est le deuxième roman de Mohamed Mbougar Sarr. À travers ce roman haletant de plus de 560 pages, décrivant l’arrivée de soixante-douze hommes subsahariens dans un village d’Italie, l’auteur s’emploie à démonter les frontières effectives et déconstruire les frontières symboliques que les hommes érigent entre eux par peur de se perdre ou se remettre en question. Le roman pointe ainsi la nécessité de faire corps social en faisant advenir la complexité des personnages et des situations, tout comme la nécessité de faire « corps avec le lieu » (Sarr, 2022, p. 119) en renouant avec la vérité profonde du mythe. Pour cela, l’auteur déploie toute une poétique au service du franchissement des frontières symboliques, qu’il s’agisse d’outrepasser la frontière des mots eux-mêmes, ou de littéralement déplacer le lecteur, en le conduisant à éprouver la durée (principale ennemie des ragazzi), ou bien la polyphonie (premier pas vers l’examen critique). Les frontières entre l’art et la vie s’en trouvent elles aussi repoussées, comme au théâtre, genre vers lequel tend l’ensemble du récit, peut-être seul à même de garantir la possibilité de « refaire corps » après le chaos.
Qubit dynamics driven by dipole field in thermal noise environment
Authors: Xiong Fan , Chen Yong-Cong , Ao Ping ,   Shanghai Center for Quantitative Life Sciences, Physics Department, Shanghai University, Shanghai 200444, China,   Colloge of Biomedical Engineering, Sichuan University, Chengdu 610065, China
Published: June 2023

Quantum computing is a new way to process quantum information by using superposition and entanglement of the quantum system. Quantum state’s vast Hilbert space allows it to perform operations that classical computers cannot. The quantum computing has unique advantages in dealing with some complex problems, so it has attracted wide attention. Computing a single qubit is the first of seven fundamental stages needed to achieve a large-scale quantum computer that is universal, scalable and fault-tolerant. In other words, the primary task of quantum computing is the careful preparation and precise regulation of qubits. At present, the physical systems that can be used as qubits include superconducting qubits, semiconductor qubits, ion trap systems and nitrogen-vacancy (NV) color centers. These physical systems have made great progress of decoherence time and scalability. Owing to the vulnerability of qubits, ambient thermal noise can cause quantum decoherence, which greatly affects the fidelity of qubits. Improving the fidelity of qubits is therefore a key step towards large-scale quantum computing. Based on the dipole field driven qubit, the stochastic dynamic structure decomposition method is adopted and the Kubo-Einstein fluctuation-dissipation theorem is used to study the qubit control in a thermal noise environment. The dipole field has components in three directions, not just in one plane, which allows more flexible control of quantum states. Without considering the noise, the quantum state can reach the target state 100%. In the noisy environment, thermal noise will cause the deviation between the actual final state and the target final state caused by thermal fluctuation, which becomes the main factor affecting the quantum fidelity. The influence of thermal noise is related to temperature and the evolution trajectory of quantum state. Therefore, this paper proposes an optimal scheme to improve the qubit fidelity in the thermal noise environment. The feasibility of this method is verified by numerical calculation, which can provide a new solution for further guiding and evaluating the experiment. The scheme is suitable for qubit systems of various physical control fields, such as semiconductor qubits and nitrogen vacancy center qubits. This work may have more applications in the development of quantum manipulation technology and can also be extended to multi-qubit systems, the details of which will appear in the future work.
Dispersive Optical Solitons with Radhakrishnan–Kundu–Lakshmanan Equation Having Multiplicative White Noise by Enhanced Kudryashov's Method and Extended Simplest Equation
Authors: Zayed Elsayed , Shohib Reham , Alngar Mohamed , Biswas Anjan , Yildirim Yakup , Dakova Anelia , Moraru Luminita , Alshehri Hashim
Published: June 2023

This article is about dispersive optical solitons with Radhakrishnan–Kundu–Lakshmanan equation with power-law of nonlinear refractive index in presence of multiplicative white noise by the usage of Itˆo calculus. The soliton solutions contain the Wiener process embedded into its phase component. Two integration algorithms make this retrieval possible and they are enhanced Kudryashov’s method and the extended simplest equation approach.
Long-range DNA end resection supports homologous recombination by checkpoint activation rather than extensive homology generation
Authors: Kimble Michael T , Johnson Matthew J , Nester Mattie R , Symington Lorraine S
Published: June 2023

Homologous recombination (HR), the high-fidelity mechanism for double-strand break (DSB) repair, relies on DNA end resection by nucleolytic degradation of the 5′-terminated ends. However, the role of long-range resection mediated by Exo1 and/or Sgs1-Dna2 in HR is not fully understood. Here, we show that Exo1 and Sgs1 are dispensable for recombination between closely linked repeats, but are required for interchromosomal repeat recombination in Saccharomyces cerevisiae. This context-specific requirement for long-range end resection is connected to its role in activating the DNA damage checkpoint. Consistent with this role, checkpoint mutants also show a defect specifically in interchromosomal recombination. Furthermore, artificial activation of the checkpoint partially restores interchromosomal recombination to exo1∆ sgs1∆ cells. However, cell cycle delay is insufficient to rescue the interchromosomal recombination defect of exo1∆ sgs1∆ cells, suggesting an additional role for the checkpoint. Given that the checkpoint is necessary for DNA damage-induced chromosome mobility, we propose that the importance of the checkpoint, and therefore long-range resection, in interchromosomal recombination is due to a need to increase chromosome mobility to facilitate pairing of distant sites. The need for long-range resection is circumvented when the DSB and its repair template are in close proximity.
A stable, distributed code for cue value in mouse cortex during reward learning
Authors: Ottenheimer David J , Hjort Madelyn M , Bowen Anna J , Steinmetz Nicholas A , Stuber Garret D
Published: June 2023

The ability to associate reward-predicting stimuli with adaptive behavior is frequently attributed to the prefrontal cortex, but the stimulus-specificity, spatial distribution, and stability of prefrontal cue-reward associations are unresolved. We trained head-fixed mice on an olfactory Pavlovian conditioning task and measured the coding properties of individual neurons across space (prefrontal, olfactory, and motor cortices) and time (multiple days). Neurons encoding cues or licks were most common in the olfactory and motor cortex, respectively. By quantifying the responses of cue-encoding neurons to six cues with varying probabilities of reward, we unexpectedly found value coding in all regions we sampled, with some enrichment in the prefrontal cortex. We further found that prefrontal cue and lick codes were preserved across days. Our results demonstrate that individual prefrontal neurons stably encode components of cue-reward learning within a larger spatial gradient of coding properties.
Gene expression plasticity followed by genetic change during colonization a high-elevation environment
Authors: She Huishang , Hao Yan , Song Gang , Luo Xu , Lei Fumin , Zhai Weiwei , Qu Yanhua
Published: June 2023

Phenotypic plasticity facilitates organismal invasion of novel environments, and the resultant phenotypic change may later be modified by genetic change, so called “plasticity first”. Herein we quantify gene expression plasticity and regulatory adaptation in a wild bird (Eurasian Tree Sparrow) from its original lowland (ancestral stage), experimentally implemented hypoxia acclimation (plastic stage) and colonized highland (colonized stage). Using a group of co-expressed genes from the cardiac and flight muscle, respectively, we demonstrate that gene expression plasticity to hypoxia tolerance is more often reversed than reinforced at the colonized stage. By correlating gene expression change with muscle phenotypes, we show that colonized tree sparrows reduce maladaptive plasticity that largely associates with decrease hypoxia tolerance. Conversely, adaptive plasticity that is congruent with increase hypoxia tolerance is often reinforced in the colonized tree sparrows. Genes displaying large levels of reinforcement or reversion plasticity (
i
.
e
., 200% of original level) show greater genetic divergence between ancestral and colonized populations. Overall, our work demonstrates that gene expression plasticity at the initial stage of high-elevation colonization can be reversed or reinforced through selection-driven adaptive modification.
Bacterial DNA on the skin surface overrepresents the viable skin microbiome
Authors: Acosta Ellen M , Little Katherine A , Bratton Benjamin P , Lopez Jaime G , Mao Xuming , Payne Aimee S , Donia Mohamed , Devenport Danelle , Gitai Zemer
Published: June 2023

The skin microbiome provides vital contributions to human health. However, the spatial organization and viability of its bacterial components remain unclear. Here, we apply culturing, imaging, and molecular approaches to human and mouse skin samples, and find that the skin surface is colonized by fewer viable bacteria than predicted by bacterial DNA levels. Instead, viable skin-associated bacteria are predominantly located in hair follicles and other cutaneous invaginations. Furthermore, we show that the skin microbiome has a uniquely low fraction of viable bacteria compared to other human microbiome sites, indicating that most bacterial DNA on the skin surface is not associated with viable cells Additionally, a small number of bacterial families dominate each skin site and traditional sequencing methods overestimate both the richness and diversity of the skin microbiome. Finally, we performed an in vivo skin microbiome perturbation-recovery study using human volunteers. Bacterial 16S rRNA gene sequencing revealed that, while the skin microbiome is remarkably stable even in the wake of aggressive perturbation, repopulation of the skin surface is driven by the underlying viable population. Our findings help explain the dynamics of skin microbiome perturbation as bacterial DNA on the skin surface can be transiently perturbed but is replenished by a stable underlying viable population. These results address multiple outstanding questions in skin microbiome biology with significant implications for future efforts to study and manipulate it.
Vita Andreæ Celsii
Authors: Societas Regia Literaria et Scientiarum
Published: June 2023

This file is a facsimile of an obituary for Anders Celsius, published in the Acta (Proceedings) of the Uppsala-based Societas Regia Literaria et Scientiarum (Royal Society of Learning and Sciences, or Kungl. Vetenskaps-Societeten i Uppsala) for the years 1744 to 1750.
Addressing Internet of Things security by enhanced sine cosine metaheuristics tuned hybrid machine learning model and results interpretation based on SHAP approach
Authors: Dobrojevic Milos , Zivkovic Miodrag , Chhabra Amit , Sani Nor Samsiah , Bacanin Nebojsa , Mohd Amin Maifuza
Published: June 2023

An ever increasing number of electronic devices integrated into the Internet of Things (IoT) generates vast amounts of data, which gets transported via network and stored for further analysis. However, besides the undisputed advantages of this technology, it also brings risks of unauthorized access and data compromise, situations where machine learning (ML) and artificial intelligence (AI) can help with detection of potential threats, intrusions and automation of the diagnostic process. The effectiveness of the applied algorithms largely depends on the previously performed optimization, i.e., predetermined values of hyperparameters and training conducted to achieve the desired result. Therefore, to address very important issue of IoT security, this article proposes an AI framework based on the simple convolutional neural network (CNN) and extreme machine learning machine (ELM) tuned by modified sine cosine algorithm (SCA). Not withstanding that many methods for addressing security issues have been developed, there is always a possibility for further improvements and proposed research tried to fill in this gap. The introduced framework was evaluated on two ToN IoT intrusion detection datasets, that consist of the network traffic data generated in Windows 7 and Windows 10 environments. The analysis of the results suggests that the proposed model achieved superior level of classification performance for the observed datasets. Additionally, besides conducting rigid statistical tests, best derived model is interpreted by SHapley Additive exPlanations (SHAP) analysis and results findings can be used by security experts to further enhance security of IoT systems.
miR-455-3p ameliorates pancreatic acinar cell injury by targeting Slc2a1
Authors: Zhan Yinchu , Chen Chenlin , Wu Zhiqiang , Zhou Feng , Yu Xinping
Published: June 2023

Objective

With the number of patients with acute pancreatitis (AP) increasing year by year, it is pressing to explore new key genes and markers for the treatment of AP. miR-455-3p/solute carrier family 2 member 1 (Slc2a1) obtained through bioinformatics analysis may participate in the progression of AP.

Materials and Methods

The C57BL/6 mouse model of AP was constructed for subsequent studies. Through bioinformatics analysis, the differentially expressed genes related to AP were screened and hub genes were identified. A caerulein-induced AP animal model was constructed to detect the pathological changes of mouse pancreas by HE staining. The concentrations of amylase and lipase were measured. Primary mouse pancreatic acinar cells were isolated and subjected to microscopy to observe their morphology. The enzymatic activities of trypsin and amylase were detected. The secretion of inflammatory cytokines in mouse were measured with the ELISA kits of TNF-α, IL-6 and IL-1β to determine pancreatic acinar cell damage. A binding site between the Slc2a1 3′ UTR region and the miR-455-3p sequence was verified by dual-luciferase reporter assay. The expression of miR-455-3p was quantified by qRT-PCR, and Slc2a1 were detected by western blot.

Results

A total of five (Fyn, Gadd45a, Sdc1, Slc2a1, and Src) were identified by bioinformatics analysis, and miR-455-3p/Slc2a1 were further studied. HE staining results showed that the AP models were successfully established by caerulein induction. In mice with AP, the expression of miR-455-3p was reduced, while that of Slc2a1 was increased. In the caerulein-induced cell model, the expression of Slc2a1 was significantly reduced after intervention of miR-455-3p mimics, whereas increased after miR-455-3p inhibitor treatment. miR-455-3p decreased the secretion of inflammatory cytokines in the cell supernatant, reduced the activity of trypsin and amylase, and alleviated the cell damage induced by caerulein. In addition, Slc2a1 3’UTR region was bound by miR-455-3p, and its protein expression was also regulated.

Conclusion

miR-455-3p alleviated caerulein-induced mouse pancreatic acinar cell damage by regulating the expression of Slc2a1.
Effects of thermal stress caused by the 2015–2016 El Niño on the biochemical composition, exoskeleton structure, and symbiont density of the fire coral Millepora alcicornis
Authors: Olguín-López Norma , Hernández-Elizárraga Víctor H , Hernández-Matehuala Rosalina , Rojas-Molina Juana I , Guevara-Gonzalez Ramón , Ibarra-Alvarado César , Rojas Molina Alejandra
Published: June 2023

Reef-forming cnidarians are essential for maintaining ecological balance. Unfortunately, coral reefs are endangered due to coral bleaching, which interrupts mutualistic symbiosis between Symbiodiniaceae algae and their coral hosts. Bleaching events result in very high coral mortality and the rapid deterioration of reef structures. Studies aimed at explaining the causes, mechanisms, and consequences of coral bleaching have been mainly conducted with anthozoans, while the impacts of thermal stress responsible for coral bleaching have been scarcely studied in hydrozoans, such as Millepora species (phylum Cnidaria, class Hydrozoa), which are the second most important reef-forming cnidarians. In the present study, the effects of thermal stress caused by the 2015–2016 El Niño on symbiont abundance, exoskeleton structure, and the biochemical composition of Millepora alcicornis were analyzed. Unbleached M. alcicornis specimens exhibited a higher abundance of Breviolum and Durisdinium species, which suggests that unbleached hydrocoral colonies might counteract thermal stress by hosting thermotolerant symbionts of the Durisdinium genus. Bleached hydrocorals exhibited lower levels of calcification than unbleached hydrocorals as well as changes in the microstructure of trabeculae and zooid pores. In contrast, thermal stress did not affect total calcium carbonate and carbohydrate content. Bleached tissues showed significantly higher levels of protein and refractory material, whereas their lipid content decreased considerably. The present study provides evidence that bleached M. alcicornis colonies suffered a decline in calcification and changes in the structure of their exoskeletons after being exposed to the 2015–2016 El Niño. The significant decrease in lipid content suggests that M. alcicornis primarily uses energy stores to maintain vital cellular processes at the expense of calcification.
Climbers of Rourkela Forest Division, Odisha, India: Food, Medicinal, Ecological and Economical Aspects
Authors: Sethi Jashabanta , Marndi Sugimani , Kumar Sanjeet
Published: June 2023

Sunlight is a scarce resource for plants growing on forest floors, yet climbers could scale trees and bushes to reach the light. Climbers are vital because they help to lower temperature and keep the forest cooler on a hot season. They provide food, shelter and many more to the wildlife and local communities. Still, they are not much explored. Therefore, a survey was carried out in Rourkela Forest Division took place during March – April 2023, and enumerated climbers along with uses. Results revealed that about 53 species of climber belonging to 20 families are available in the study areas. They are used by local communities as food, medicine, source of livelihood and have ecological values. Therefore, authors summarised the diversity of climber and documented it in a scientific manner for future restoration and making plant for value addition in study areas.
Teaching Competence Model of Secondary Teachers in Filipino
Authors: Gapol Avelino T. , Limpot Marilou Y.
Published: June 2023

Objectives: To determine the best fit model of teaching competences of Filipino teachers in secondary.

Methodology: The respondents were 400 Filipino teachers from public schools in Region 11, Southern Mindanao, Philippines. The respondents were chosen using stratified random sampling. The data were collected using google forms.

Results and Discussion: The overall results showed that the respondents had a high level of professional identity, competence of teachers, professional competencies and teaching competences. It also showed a significant relationship between three variables: professional identity, competence of teachers and professional competencies in teaching competences of teachers. Among the five models, model 5 best fits the study.

Recommendations: Based on the results of the study, the researcher proposed the recommendation to continue and maintain the valuation of the four variables of professional identity, teachers' competence, professional competence, and teaching competence by using them as a basis for the selection of good teachers who possess teaching ability. Moreover, they both obtained the highest descriptive level.
Efficacy and Safety of High Dose of Lansoprazole Pretreatment in Patients with Breast Cancer Receiving Neo-Adjuvant Chemotherapy
Authors: Mohamed Samah Hussein , Alagizy H. A. , Mostafa Tarek M. , El-Afify Dalia
Published: June 2023

Background: High dosage of lansoprazole (LPZ) can be used to control acidic microenvironment surrounding the cancerous cells thus improving tumor response.

Aim: The study aimed at investigating the possible antitumor efficacy and safety of high dose of LPZ pretreatment in patients with breast cancer (BC) receiving neo-adjuvant chemotherapy (NAC).

Study Design:  Single blinded, randomized placebo-controlled study.

Place and Duration of Study: The study was conducted between June 2021 and November 2022 at Clinical Oncology and Nuclear Medicine Department, Menoufia University Hospital, Egypt.

Methodology: 66 females with stage II and III BC were randomly assigned into two groups; the LPZ group (n=33) which started LPZ capsules 60 mg orally bid 4 days before starting NAC and the control group (n=33) which received placebo capsules and the same NAC regimen as LPZ group. Evaluation of tumor response was done according to the Response Evaluation Criteria in Solid Tumors (RECIST, v1.1). Permeability-glycoprotein (P-gp) and Ki-67 levels were assessed in the two groups before and after treatment. Adverse events were documented and graded using National Cancer Institute-Common Terminology Criteria for Adverse Events (NCI-CTCAE, v5). Trial Registration: ClinicalTrials.gov identifier: NCT04874935.

Results: Lansoprazole group showed more favorable response especially within luminal B/HER2 negative subtype. Lansoprazole group showed non-significant decrease in P-gp (P = 0.19) and Ki-67 (P = 0.44) levels as compared to the control group. Dyspepsia was the only significant adverse effect reported with LPZ group (P = 0.011).

Conclusion: However, LPZ didn't reveal a statistically significant anti-tumor effect as compared to placebo; it produced a clinically important improvement in tumor response which was translated by higher number of patients who achieved complete response. Furthermore, the high dose of LPZ used during this study was tolerable and safe.
Histopathological Cellular and Diagnostic Features of Tuberculous Lymphadenitis
Authors: Jain Sonal , Singh Kalpana
Published: June 2023

Background: Tuberculosis (TB) remains a global health problem with 25% of the world’s population infected from the causative agent Mycobacterium tuberculosis(MTB). Indian ranks first amongst the eight countries reported to have highest burden of MTB across the globe. TB is categorized into pulmonary and extrapulmonary(EPTB); the most common clinical manifestation of EPTB being tuberculous lymphadenitis(LNTB). LNTB generally occurs due to reactivation of latent infection and cervical lymph nodes are the most common sites.

Objective: The present research work was conducted to explore disease spectrum of LNTB highlighting specific histopathologic features.

Materials and Methods: Twenty-one patients with clinically diagnosed LNTB were included and one lymph node biopsy was obtained from each patient. The formalin-fixed paraffin tissue sections were subjected to standard hematoxylin & eosin staining (H & E stain) to understand different histologic features of LNTB.

Results: LNTB displayed a disease spectrum which can be categorized into four broad categories as: 1. Early granulomas(n=2); 2. Non-caseating granulomas(n=12); 3. Caseating granulomas(n=6); 4. Massive extensive caseation without Langhan’s giant cells(n=1). The well-formed, non-necrotic, epithelioid cell granulomas were prominent feature of LNTB in our study.

Conclusion: The above study supports the existence of a disease spectrum of LNTB with histologic features ranging from early granulomas to massive caseation necrosis. This can aid clinicians for better diagnosis of LNTB so to aid for early detection and an appropriate treatment of the disease.
Antecedents of Consumer Purchase Intention of Fashion Products
Authors: Sutanto Eddy Madiono , Widianto Yana
Published: June 2023

Fashion products are such dynamic products. Therefore, understanding well to consumer intention is very important for producers as well as distributors. This study aimed to determine the effect of credibility, attractiveness, product suitability with personality, and celebrity recognition on consumer purchase intentions of Greenlight fashion products. The research data was collected using a questionnaire distributed to 109 respondents aged 15–31 years who knew Ariel Noah as a Greenlight product ad star, had seen Greenlight product advertisements, and had bought Greenlight fashion products. The data was processed using the multiple linear regression method. The results suggested that the credibility, attractiveness, and suitability of products with celebrity personalities positively and significantly affected consumers' purchase intentions of Greenlight fashion products. However, ce­lebrity re­cognition had no significant effect on consumer purchase intentions for Greenlight fashion products. By con­si­dering the results, the stakeholders shall adjust their strategies to keep and enlarge their market shares further.
Identificação do Perfil Tecnológico da UEPB: mapeamento de pesquisas com potencial inovador
Authors: Santos Flavia , Lopes Simone , Prazeres Yedda
Published: June 2023

Com intuito de identificar o perfil tecnológico da UEPB e as pesquisas com potencial inovador, foram analisadas tecnologias protegidas, traçando o perfil tecnológico da instituição. Posteriormente, foram mapeadas as pesquisas com potencial inovador submetidos aos editais de iniciação científica e tecnológica nos anos de 2011-2021, a escolha foi de acordo com as grandes áreas da Capes e Classificação Internacional de Patentes (CIP). Foi identificado que a maior parte das tecnologias protegidas ocorreu na forma de patentes, seguindo pelo registro de software, não sendo observados outros tipos de proteção. Quanto ao perfil tecnológico, a área de Ciências da Saúde destaca-se em termos de produção tecnológica. Contudo, 76% das pesquisas possuem potencial inovador, podendo ser protegidas. Logo, é possível traçar o retrato tecnológico institucional por meio do monitoramento periódico dessas tecnologias, contribuindo para o planejamento de ações e visando a estimular a proteção intelectual e a transferência tecnológica na UEPB.
Prospecção de Aeronaves Remotamente Pilotadas (RPA) para Agricultura no Brasil
Authors: Severino Elcio Manoel , Basso Micheli Cristiani Aiello , Melotti Leonardo Marcondes Domingues
Published: June 2023

Na agricultura, os sistemas de RPAs são utilizados para realizar diversas atividades, por exemplo, pulverização, mapeamento agrícola, vigilância, entre outros. O objetivo deste trabalho foi realizar uma pesquisa quantitativa de patentes relacionadas à utilização dos sistemas de RPA voltados para a agricultura no Brasil nos últimos 20 anos, se propondo a identificar os principais setores do agronegócio que utilizam a tecnologia, cenários futuros e tendências de uso. Para isso, adotou-se uma abordagem quantitativa, de caráter exploratório, por meio da prospecção tecnológica tendo como base de dados o Orbit e o INPI. Como resultado, foram identificadas 33 patentes relacionadas ao tema, sendo 39,4% com direitos garantidos, 42,4% pendentes, 15,2% revogadas e 3% em domínio público. Conclui-se que o agronegócio brasileiro vem utilizando, cada vez mais, drones, VANT ou RPA devido às diversas possibilidades de uso dentro do setor e por causa das vantagens oriundas da sua utilização, como redução dos custos ou melhores práticas de manejo.
The Scope and Legal Implications of Tracking Technologies on Hospital Websites
Authors: McCoy Matthew S. , Friedman Ari B. , Hoffman Allison K.
Published: June 2023

This Viewpoint analyzes the scope and legal implications of tracking on hospital websites, including potential HIPAA and state privacy law violations, and suggests that hospitals limit such tracking.
The Gregor Mendel Bicentennial Tribute—Enduring Mementos of the Founder of Genetics
Authors: Mulvihill John J. , Grody Wayne W.
Published: June 2023

This Arts and Medicine feature summarizes events and scholarship honoring Abbot Gregor Mendel, founder of the science of modern genetics, on the occasion of the bicentennial of his birth.
Injury Patterns and Hospital Admission After Trauma Among People Experiencing Homelessness
Authors: Silver Casey M. , Thomas Arielle C. , Reddy Susheel , Sullivan Gwyneth A. , Plevin Rebecca E. , Kanzaria Hemal K. , Stey Anne M.
Published: June 2023

Importance

Traumatic injury is a major cause of morbidity for people experiencing homelessness (PEH). However, injury patterns and subsequent hospitalization among PEH have not been studied on a national scale.

Objective

To evaluate whether differences in mechanisms of injury exist between PEH and housed trauma patients in North America and whether the lack of housing is associated with increased adjusted odds of hospital admission.

Design, Setting, and Participants

This was a retrospective observational cohort study of participants in the 2017 to 2018 American College of Surgeons’ Trauma Quality Improvement Program. Hospitals across the US and Canada were queried. Participants were patients aged 18 years or older presenting to an emergency department after injury. Data were analyzed from December 2021 to November 2022.

Exposures

PEH were identified using the Trauma Quality Improvement Program’s alternate home residence variable.

Main Outcomes and Measures

The primary outcome was hospital admission. Subgroup analysis was used to compared PEH with low-income housed patients (defined by Medicaid enrollment).

Results

A total of 1 738 992 patients (mean [SD] age, 53.6 [21.2] years; 712 120 [41.0%] female; 97 910 [5.9%] Hispanic, 227 638 [13.7%] non-Hispanic Black, and 1 157 950 [69.6%] non-Hispanic White) presented to 790 hospitals with trauma, including 12 266 PEH (0.7%) and 1 726 726 housed patients (99.3%). Compared with housed patients, PEH were younger (mean [SD] age, 45.2 [13.6] years vs 53.7 [21.3] years), more often male (10 343 patients [84.3%] vs 1 016 310 patients [58.9%]), and had higher rates of behavioral comorbidity (2884 patients [23.5%] vs 191 425 patients [11.1%]). PEH sustained different injury patterns, including higher proportions of injuries due to assault (4417 patients [36.0%] vs 165 666 patients [9.6%]), pedestrian-strike (1891 patients [15.4%] vs 55 533 patients [3.2%]), and head injury (8041 patients [65.6%] vs 851 823 patients [49.3%]), compared with housed patients. On multivariable analysis, PEH experienced increased adjusted odds of hospitalization (adjusted odds ratio [aOR], 1.33; 95% CI, 1.24-1.43) compared with housed patients. The association of lacking housing with hospital admission persisted on subgroup comparison of PEH with low-income housed patients (aOR, 1.10; 95% CI, 1.03-1.19).

Conclusions and Relevance

Injured PEH had significantly greater adjusted odds of hospital admission. These findings suggest that tailored programs for PEH are needed to prevent their injury patterns and facilitate safe discharge after injury.
Sudden-Onset Bilateral Mydriasis in a Young Girl
Authors: Shaath Deena S. , Scheidt Abigail F. , Stiff Heather A.
Published: June 2023

A 3-year-old girl presented to the emergency department with 1 day of abnormal gait and bilateral mydriasis. Repeat magnetic resonance imaging demonstrated diffuse enhancement of the lower thoracic and cauda equina nerve roots and enhancement of the left oculomotor nerve.
History and Trends in Industrial Toxicology
Authors: Saghir Shakil A. , Ewert Donald H. , Ansari Rais A.
Published: June 2023

The first recognition of occupational diseases along with long working hours, poor ventilation, and use of child labor was in 1835. Recognition of relationship between workplace chemical agents and disease evolved rapidly in Europe, stimulated by 1885 Germany's Bismarck Workingmen's Insurance Law, establishing insurance fund for contribution from both employers and employees for free medical care and compensation for injuries. By the 1930s, three of the largest U.S. chemical companies (Dow, DuPont, Union Carbide) established in‐house laboratories specializing in toxicology to handle exposures and occupational toxicity. Walsh‐Healey Public Contracts Act was passed in 1936 mandating government contractors to meet standards for sanitation and safety. ACGIH and AIHA were founded in 1939. In 1958, Congress amended the FDCA of 1938 requiring proof of safety from lifetime exposures. The
Journal of Industrial Hygiene and Toxicology
began publication in 1923 and joined the
Archives of Industrial Hygiene and Occupational Medicine
in 1950. First edition of Patty's Toxicology and Industrial Hygiene was published in 1948. SOT was established in 1961 and launched journal, Toxicology and Applied Pharmacology. Cancer is of great concern in industrial toxicology and historically, some of the most relevant research in carcinogens has come from the industries based on human and experimental studies. Short‐term tests and MOA (
in silico
,
in vitro
, and/or
in vivo
) are now commonly used to determine potential hazards. U.S. EPA is furthering the use of all existing and emerging technologies for risk assessment through NAMs to reduce animal testing. This chapter covers trends in industrial toxicology from observational toxicology to present.
Chemical Toxicity Information Sources
Authors: Holmgren Stephanie
Published: June 2023

The headlines on bisphenol‐A, glyphosate, triclosan, and many other exposures exemplify how accurate and current toxicology information played a critical role in making sound decisions related to characterizing the hazard and risk from exposure to those substances. Information is necessary to understand the health hazard and contributing underlying mechanisms, determine dose response, assess exposure risk, treat exposed patients, establish exposure limits, set regulations, develop safer alternatives, among many other actions. The above examples illustrate the importance of being able to obtain relevant, up‐to‐date information about the adverse effects of a chemical to protect the health of man and the environment. The challenge is how to locate and evaluate the necessary information given the magnitude of available information and the multiple ways one can access it. Therefore, the intent of this chapter is to direct readers to useful starting points for chemical toxicity and related information. In addition, guidance is provided at the end of the chapter on how to successfully search the web and literature databases to find the relevant information one seeks.
Fiberglass (Glass Wool)
Authors: Houghton Carol , de Reydellet Aymon
Published: June 2023

This chapter contains information on glass wool only. Chemical and physical properties, production and use, workplace assessment of exposure, assessment of toxic effects, and regulatory classifications are given.

In October 2001, the International Agency for Research on Cancer (IARC) re‐classified glass wool and other commercially available insulation wools as Group 3 (not classifiable as to its carcinogenicity in humans), i.e., not suspected of causing cancer in humans.

Current regulatory guidance and the health classifications for biosoluble glass wools used in the United States and Europe show no concerns for human carcinogenicity, and exposure levels are very low.
Metallocenes
Authors: Bade Steffen
Published: June 2023

Metallocenes are organometallic sandwich complexes that have been used in or investigated for multiple application fields, such as chemical intermediates, antiknock additives to gasoline, lubricants or anti‐cancer agents. The main application of metallocenes, however, is the use as catalysts during plastic production. Due to the widespread applications and increasing plastic production interest increased on potential health effects induced by metallocenes. The chapter describes commonly used metallocenes and summarizes available toxicological data and assessments.
Beryllium
Authors: Rossman Milton D. , Wambach Paul F. , Ziegler‐Skylakakis Kyriakoula , Kolanz Marc
Published: June 2023

Beryllium, found in a variety of different forms, has become indispensable in modern high‐technology industries, especially aerospace. It has many attractive properties, including light weight, high strength, and heat resistance. Unfortunately, beryllium is associated with a number of toxic effects. Even under controlled conditions, beryllium metal, oxide, and alloys can cause chronic lung disease among individuals exposed to dust or fume.

Identifying properties of different forms of beryllium are described in Section 1 followed by sections which describe the properties and characteristics of beryllium. These include production and use, toxic effects, standards, and exposure assessment.
Aromatic Nitro and Amino Compounds
Authors: Johnson Mark S.
Published: June 2023

Aromatic nitro and amino compounds have various commercial, governmental, and public applications. Their uses include manufacturing of dyes, pesticides, drugs, and explosives. These substances are typically considered high‐nitrogen compounds and as such share many of the same chemical and biological properties. Many have amines and/or nitrate groups on the ring and because of this exhibit properties where they are not highly water or lipid soluble and many tend to form crystals. When released to the environment, nitrate‐containing moieties are often reduced to amines by bacteria in wet soils and sediments. Acute effects typically target the nervous system; however, sublethal effects from repetitive exposures include anemia, methemoglobinemia, and often male reproductive effects. Cyanosis has been described from relatively high repetitive exposures. Oral exposures can affect the liver. Many are absorbed through the skin where dermal exposures can significantly contribute to systemic dose. Skin sensitization and irritation have been observed from exposure to some compounds. Many are eliminated via the urine; however, conjugated metabolites can be eliminated via the feces. Nitroso metabolites are suspected as having influence in observation of cancer, particularly in the bladder. Other similar nitramine compounds are also briefly described.
Genetic Toxicology: Basics and Practical Insights into Its Appropriate Application
Authors: Pottenger Lynn H. , Gollapudi B. Bhaskar , Moore Martha M.
Published: June 2023

Genetic toxicology data play an important role in a variety of regulatory applications. Thus, industrial hygienists and toxicologists need a basic understanding of the principles and testing approaches for the evaluation of genotoxicity. Genetox tests are used for hazard assessment, to support the classification of chemicals as carcinogens or mutagens, and to support the evaluation of modes of action for tumor induction. Genetic toxicology has primarily been used in the evaluation of potential carcinogens, and for predicting potential germ cell and heritable risk. More recent considerations include using genetic damage as a standalone adverse outcome. Many genetox tests are recommended for regulatory use, with OECD test guidelines that describe conduct and data interpretation. Since these recommendations have evolved over the years, data from older studies must be carefully evaluated before accepting study conclusions.
In silico
models now contribute by complementing the biological tests. This chapter includes our insights into strategies for selecting appropriate tests and generating optimal data sets to address specific questions and advice for conducting weight of the evidence evaluations on information from multiple endpoints and tests. Genetic toxicology data provide not only qualitative results, but with careful study design, can also provide information useful to address dose–response issues.