bluuebunny/crossref_metadata_2025 huggingface dataset:
Cardiological Biopharmaceuticals in the Conception of Drug Targeting Delivery: Practical Results and Research Perspectives
Authors: Maksimenko A. V.
Published: July 2019

The results of the clinical use of thrombolytic and antithrombotic preparations developed on the basis of protein conjugates obtained within the framework of the conception of drug targeting delivery in the organism are considered. A decrease has been noted in the number of biomedical projects focused on these derivatives as a result of various factors: the significant depletion of financial and organizational funds, the saturation of the pharmaceutical market with preparations of this kind, and the appearance of original means for interventional procedures. Factors that actively facilitate the conspicuous potentiation of the efficacy of bioconjugates were revealed: the biomedical testing of protein domains and their selected combinations, the optimization of molecular sizes for the bioconjugates obtained, the density of target localization, the application of cell adhesion molecules as targets, and the application of connected enzyme activities. Enzyme antioxidants and the opportunity for further elaboration of the drug delivery conception via the elucidation and formation of therapeutic targets for effective drug reactions by means of pharmacological pre- and postconditioning of myocardium arouse significant interest.
Non-Thermal Plasma Causes P53-Dependent Apoptosis in Human Colon Carcinoma Cells
Authors: Tuhvatulin A. I. , Sysolyatina E. V. , Scheblyakov D. V. , Logunov D. Yu. , Vasiliev M. M. , Yurova M. A. , Danilova M. A. , Petrov O. F. , Naroditsky B. S. , Morfill G. E. , Grigoriev A. I. , Fortov V. E. , Gintsburg A. L. , Ermolaeva S. A.
Published: July 2019

Non-thermal plasma (NTP) consists of a huge amount of biologically active particles, whereas its temperature is close to ambient. This combination allows one to use NTP as a perspective tool for solving different biomedical tasks, including antitumor therapy. The treatment of tumor cells with NTP caused dose-dependent effects, such as growth arrest and apoptosis. However, while the outcome of NTP treatment has been established, the molecular mechanisms of the interaction between NTP and eukaryotic cells have not been thoroughly studied thus far. In this work, the mechanisms and the type of death of human colon carcinoma HCT 116 cells upon application of non-thermal argon plasma were studied. The effect of NTP on the major stress-activated protein p53 was investigated. The results demonstrate that the viability of HCT116 cells upon plasma treatment is dependent on the functional p53 protein. NTP treatment caused an increase in the intracellular concentration of p53 and the induction of the p53-controlled regulon. The p53-dependent accumulation of active proapoptotic caspase-3 was shown in NTP-treated cells. The study was the first to demonstrate that treatment of human colon carcinoma cells with NTP results in p53-dependent apoptosis. The results obtained contribute to our understanding of the applicability of NTP in antitumor therapy.
N-Terminal Fusion Tags for Effective Production of G-Protein-Coupled Receptors in Bacterial Cell-Free Systems
Authors: Lyukmanova E. N. , Shenkarev Z. O. , Khabibullina N. F. , Kulbatskiy D. S. , Shulepko M. A. , Petrovskaya L. E. , Arseniev A. S. , Dolgikh D. A. , Kirpichnikov M. P.
Published: July 2019

G-protein-coupled receptors (GPCR) constitute one of the biggest families of membrane proteins. In spite of the fact that they are highly relevant to pharmacy, they have remained poorly explored. One of the main bottlenecks encountered in structural-functional studies of GPCRs is the difficulty to produce sufficient amounts of the proteins. Cell-free systems based on bacterial extracts from E. coli cells attract much attention as an effective tool for recombinant production of membrane proteins. GPCR production in bacterial cell-free expression systems is often inefficient because of the problems associated with the low efficiency of the translation initiation process. This problem could be resolved if GPCRs were expressed in the form of hybrid proteins with N-terminal polypeptide fusion tags. In the present work, three new N-terminal fusion tags are proposed for cellfree production of the human 2-adrenergic receptor, human M1 muscarinic acetylcholine receptor, and human somatostatin receptor type 5. It is demonstrated that the application of an N-terminal fragment (6 a.a.) of bacteriorhodopsin from Exiguobacterium sibiricum (ESR-tag), N-terminal fragment (16 а.о.) of RNAse A (S-tag), and Mistic protein from B. subtilis allows to increase the CF synthesis of the target GPCRs by 538 times, resulting in yields of 0.63.8 mg from 1 ml of the reaction mixture, which is sufficient for structural-functional studies.
Use of Transgenic Animals in Biotechnology: Prospects and Problems
Authors: Maksimenko O. G. , Deykin A. V. , Khodarovich Yu. M. , Georgiev P. G.
Published: July 2019

During the past two decades, there have been numerous attempts at using animals in order to produce recombinant human proteins and monoclonal antibodies. However, it is only recently that the first two therapeutic agents isolated from the milk of transgenic animals, C1 inhibitor (Ruconest) and antithrombin (ATryn), appeared on the market. This inspires hope that a considerable number of new recombinant proteins created using such technology could become available for practical use in the near future. In this review, the methods applied to produce transgenic animals are described and the advantages and drawbacks related to their use for producing recombinant human proteins and monoclonal antibodies are discussed.
Recombinant Human Butyrylcholinesterase As a New-Age Bioscavenger Drug: Development of the Expression System
Authors: Ilyushin D. G. , Haertley O. M. , Bobik T. V. , Shamborant O. G. , Surina E. A. , Knorre V. D. , Masson P. , Smirnov I. V. , Gabibov A. G. , Ponomarenko N. A.
Published: July 2019

Butyrylcholinesterase (BChE) is a serine hydrolase (EC 3.1.1.8) which can be found in most animal tissues. This enzyme has a broad spectrum of efficacy against organophosphorus compounds, which makes it a prime candidate for the role of stoichiometric bioscavenger. Development of a new-age DNA-encoded bioscavenger is a vival task. Several transgenic expression systems of human BChE were developed over the past 20 years; however, none of them has been shown to make economic sense or has been approved for administration to humans. In this study, a CHO-based expression system was redesigned, resulting in a significant increase in the production level of functional recombinant human butyrylcholinesterase as compared to the hitherto existing systems. The recombinant enzyme was characterized with Elman and ELISA methods.
Genetic Diversity of Bacillus thuringiensis from Different Geo-Ecological Regions of Ukraine by Analyzing the 16S rRNA and gyrB Genes and by AP-PCR and saAFLP
Authors: Punina N. V. , Zotov V. S. , Parkhomenko A. L. , Parkhomenko T. Y. , Topunov A. F.
Published: July 2019

The Bacillus cereus group consists of closely related species of bacteria and is of interest to researchers due to its importance in industry and medicine. However, it remains difficult to distinguish these bacteria at the intra- and inter-species level. Bacillus thuringiensis (Bt) is a member of the B. cereus group. In this work, we studied the inter-species structure of five entomopathogenic strains and 20 isolates of Bt, which were collected from different geo-ecological regions of Ukraine, using various methods: physiological and biochemical analyses, analysis of the nucleotide sequences of the 16S rRNA and gyrB genes, by AP-PCR (BOX and ERIC), and by saAFLP. The analysis of the 16S rRNA and gyrB genes revealed the existence of six subgroups within the B. cereus group: B anthracis, B. cereus I and II, Bt I and II, and Bt III, and confirmed that these isolates belong to the genus Bacillus. All strains were subdivided into 3 groups. Seventeen strains belong to the group Bt II of commercial, industrial strains. The AP-PCR (BOX and ERIC) and saAFLP results were in good agreement and with the results obtained for the 16S rRNA and gyrB genes. Based on the derived patterns, all strains were reliably combined into 5 groups. Interestingly, a specific pattern was revealed by the saAFLP analysis for the industrial strain Bt 0376 р.о., which is used to produce the entomopathogenic preparation STAR-t.
Blood Clotting Factor VIII: From Evolution to Therapy
Authors: Orlova N. A. , Kovnir S. V. , Vorobiev I. I. , Gabibov A. G. , Vorobiev A. I.
Published: July 2019

Recombinant blood clotting factor VIII is one of the most complex proteins for industrial manufacturing due to the low efficiency of its gene transcription, massive intracellular loss of its proprotein during post-translational processing, and the instability of the secreted protein. Improvement in hemophilia A therapy requires a steady increase in the production of factor VIII drugs despite tightening standards of product quality and viral safety. More efficient systems for heterologous expression of factor VIII can be created on the basis of the discovered properties of its gene transcription, post-translational processing, and behavior in the bloodstream. The present review describes the deletion variants of factor VIII protein with increased secretion efficiency and the prospects for the pharmaceutical development of longer acting variants and derivatives of factor VIII.
Late Replication of the Inactive X Chromosome Is Independent of the Compactness of Chromosome Territory in Human Pluripotent Stem Cells
Authors: Panova A. V. , Nekrasov E. D. , Lagarkova M. A. , Kiselev S. L. , Bogomazova A. N.
Published: July 2019

Dosage compensation of the X chromosomes in mammals is performed via the formation of facultative heterochromatin on extra X chromosomes in female somatic cells. Facultative heterochromatin of the inactivated X (Xi), as well as constitutive heterochromatin, replicates late during the S-phase. It is generally accepted that Xi is always more compact in the interphase nucleus. The dense chromosomal folding has been proposed to define the late replication of Xi. In contrast to mouse pluripotent stem cells (PSCs), the status of X chromosome inactivation in human PSCs may vary significantly. Fluorescence in situ hybridization with a whole X-chromosome-specific DNA probe revealed that late-replicating Xi may occupy either compact or dispersed territory in human PSCs. Thus, the late replication of the Xi does not depend on the compactness of chromosome territory in human PSCs. However, the Xi reactivation and the synchronization in the replication timing of X chromosomes upon reprogramming are necessarily accompanied by the expansion of X chromosome territory.
Mycobacterium tuberculosis Transcriptome Profiling in Mice with Genetically Different Susceptibility to Tuberculosis
Authors: Skvortsov T. A. , Ignatov D. V. , Majorov K. B. , Apt A. S. , Azhikina T. L.
Published: July 2019

Whole transcriptome profiling is now almost routinely used in various fields of biology, including microbiology. In vivo transcriptome studies usually provide relevant information about the biological processes in the organism and thus are indispensable for the formulation of hypotheses, testing, and correcting. In this study, we describe the results of genome-wide transcriptional profiling of the major human bacterial pathogen M. tuberculosis during its persistence in lungs. Two mouse strains differing in their susceptibility to tuberculosis were used for experimental infection with M. tuberculosis. Mycobacterial transcriptomes obtained from the infected tissues of the mice at two different time points were analyzed by deep sequencing and compared. It was hypothesized that the changes in the M. tuberculosis transcriptome may attest to the activation of the metabolism of lipids and amino acids, transition to anaerobic respiration, and increased expression of the factors modulating the immune response. A total of 209 genes were determined whose expression increased with disease progression in both host strains (commonly upregulated genes, CUG). Among them, the genes related to the functional categories of lipid metabolism, cell wall, and cell processes are of great interest. It was assumed that the products of these genes are involved in M. tuberculosis adaptation to the host immune system defense, thus being potential targets for drug development.
Peculiarities of the Regulation of Gene Expression in the Ecl18kI Restriction–Modification System
Authors: Burenina O. Yu. , Fedotova E. A. , Ryazanova A. Yu. , Protsenko A. S. , Zakharova M. V. , Karyagina A. S. , Solonin A. S. , Oretskaya T. S. , Kubareva E. A.
Published: July 2019

Transcription regulation in bacterial restrictionmodification (RM) systems is an important process, which provides coordinated expression levels of tandem enzymes, DNA methyltransferase (MTase) and restriction endonuclease (RE) protecting cells against penetration of alien DNA. The present study focuses on (cytosine-5)-DNA methyltransferase Ecl18kI (M.Ecl18kI), which is almost identical to DNA methyltransferase SsoII (M.SsoII) in terms of its structure and properties. Each of these enzymes inhibits expression of the intrinsic gene and activates expression of the corresponding RE gene via binding to the regulatory site in the promoter region of these genes. In the present work, complex formation of M.Ecl18kI and RNA polymerase from Escherichia сoli with the promoter regions of the MTase and RE genes is studied. The mechanism of regulation of gene expression in the Ecl18kI RM system is thoroughly investigated. M.Ecl18kI and RNA polymerase are shown to compete for binding to the promoter region. However, no direct contacts between M.Ecl18kI and RNA polymerase are detected. The properties of M.Ecl18kI and M.SsoII mutants are studied. Amino acid substitutions in the N-terminal region of M.Ecl18kI, which performs the regulatory function, are shown to influence not only M.Ecl18kI capability to interact with the regulatory site and to act as a transcription factor, but also its ability to bind and methylate the substrate DNA. The loss of methylation activity does not prevent MTase from performing its regulatory function and even increases its affinity to the regulatory site. However, the presence of the domain responsible for methylation in the M.Ecl18kI molecule is necessary for M.Ecl18kI to perform its regulatory function.
Metagenomic Analysis of the Dynamic Changes in the Gut Microbiome of the Participants of the MARS-500 Experiment, Simulating Long Term Space Flight
Authors: Mardanov A. V. , Babykin M. M. , Beletsky A. V. , Grigoriev A. I. , Zinchenko V. V. , Kadnikov V. V. , Kirpichnikov M. P. , Mazur A. M. , Nedoluzhko A. V. , Novikova N. D. , Prokhortchouk E. B. , Ravin N. V. , Skryabin K. G. , Shestakov S. V.
Published: July 2019

A metagenomic analysis of the dynamic changes of the composition of the intestinal microbiome of five participants of the MARS-500 experiment was performed. DNA samples were isolated from the feces of the participants taken just before the experiment, upon 14, 30, 210, 363 and 510 days of isolation in the experimental module, and two weeks upon completion of the experiment. The taxonomic composition of the microbiome was analyzed by pyrosequencing of 16S rRNA gene fragments. Both the taxonomic and functional gene content of the microbiome of one participant were analyzed by whole metagenome sequencing using the SOLiD technique. Each participant had a specific microbiome that could be assigned to one of three recognized enterotypes. Two participants had enterotype I microbiomes characterized by the prevalence of Bacteroides, while the microbiomes of two others, assigned to type II, were dominated by Prevotella. One participant had a microbiome of mixed type. It was found that (1) changes in the taxonimic composition of the microbiomes occurred in the course of the experiment, but the enterotypes remained the same; (2) significant changes in the compositions of the microbiomes occurred just 14-30 days after the beginning of the experiment, presumably indicating the influence of stress factors in the first stage of the experiment; (3) a tendency toward a reversion of the microbiomes to their initial composition was observed two weeks after the end of the experiment, but complete recovery was not achieved. The metagenomic analysis of the microbiome of one of the participants showed that in spite of variations in the taxonomic compositions of microbiomes, the functional genetic composition was much more stable for most of the functional gene categories. Probably in the course of the experiment the taxonomic composition of the gut microbiome was adaptively changed to reflect the individual response to the experimental conditions. A new, balanced taxonomic composition of the microbiome was formed to ensure a stable gene content of the community as a whole without negative consequences for the health of the participants.
Modern Aspects of the Structural and Functional Organization of the DNA Mismatch Repair System
Authors: Perevoztchikova S. A. , Romanova E. A. , Oretskaya T. S. , Friedhoff P. , Kubareva E. A.
Published: July 2019

This review is focused on the general aspects of the DNA mismatch repair (MMR) process. The key proteins of the DNA mismatch repair system are MutS and MutL. To date, their main structural and functional characteristics have been thoroughly studied. However, different opinions exist about the initial stages of the mismatch repair process with the participation of these proteins. This review aims to summarize the data on the relationship between the two MutS functions, ATPase and DNA-binding, and to systematize various models of coordination between the mismatch site and the strand discrimination site in DNA. To test these models, novel techniques for the trapping of short-living complexes that appear at different MMR stages are to be developed.
Original Nerve Growth Factor Mimetic Dipeptide GK-2 Restores Impaired Cognitive Functions in Rat Models of Alzheimer’s Disease
Authors: Povarnina P. Yu. , Vorontsova O. N. , Gudasheva T. A. , Ostrovskaya R. U. , Seredenin S. B.
Published: July 2019

Dipeptide mimetic of the nerve growth factor (NGF) loop 4, hexamethylenediamide bis-(N-monosuccinyl-glutamyl-lysine) (GK-2), was synthesized at the V.V. Zakusov Scientific Research Institute of Pharmacology of the Russian Academy of Medical Sciences. GK-2 exhibited in vitro neuroprotective activity at nanomolar concentrations, was efficient in animal models of the Parkinsons disease, ischemic and hemorrhagic stroke, and global cerebral ischemia at doses of 0.015 mg/kg (intraperitoneally) and 10 mg/kg (per os). The mnemotropic effects of subchronic intraperitoneal administration of GK-2 on rat models of the Alzheimers disease are described in this paper. Dipeptide GK-2 at a dose of 1 mg/kg is found to decrease the habituation deficit induced by the septo-hippocampal pathway transsection and, at a dose of 0.5 mg/kg, to significantly prevent spatial memory impairment in Morris water maze induced by intracerebral injection of streptozotocin. Thus, GK-2, an original dipeptide mimetic of NGF, acts on models of the Alzheimers disease upon systemic administration.
The Impact of ADH1B Alleles and Educational Status on Levels and Modes of Alcohol Consumption in Russian Male Individuals
Authors: Borinskaya S. A. , Kim A. A. , Rubanovich A. V. , Yankovsky N. K.
Published: July 2019

Alcohol abuse is one of the main reasons behind the low life span in Russia. Both social and genetic factors affect the alcohol consumption level. The genetic factors are alleles of the alcohol dehydrogenase ADH1B and aldehyde dehydrogenaseALDH2 genes. We have typed and found frequencies for the alleles in a cohort of 642 men, ethnic Russians. The individuals of the cohort were asked to complete a questionnaire in the framework of the Izhevsk Family Study (Leon et al., 2007, 2009) regarding the amount of alcohol consumed and on the type of hazardous alcohol consumption (nonbeverage alcohol consumption and the so-called zapo which is a Russian term for a heavy drinking bout lasting for at least 2 days, when an individual is withdrawn from the normal social life). The ADH1B*48His allele was found among heterozygous individuals only (N=68, 10.6% of the cohort). The ALDH2*504Lys allele was also found among heterozygous individuals only (N=2, 0.3%) The effect of ADH1B alleles and the influence of the education level on the amount and type of alcohol consumed had not previously been studied in Russians. We have found that the amount of consumed alcohol is 21.6% lower (1733 g of ethanol per year) for ADH1B*48His allele carriers in the cohort of Russian men. The amount of consumed alcohol was found to be 9.8% lower (793 g of ethanol per year) in the case when individuals had a higher education as compared to those who had a secondary- or elementary school education level in the same cohort. Hence, the protective effect of the genetic factor (ADH1B*48His allele carriage) has proven to be more pronounced than the influence of the social factor (education level) at the individual level in the cohort of Russian men. Both factors have also proven to have a protective effect against hazardous types of alcohol consumption. Zapo was not scored among individuals of the cohort with ADH1B*48His allele carriage (OR=12.6, P=0.006), as compared to 8.4% of zapo individuals who did not carry the ADH1B*48His allele (genotype Arg/Arg).The percentage of individuals who consume non-beverage alcohol is lower (0.6%) in the subcohort of people with a higher education degree. This percentage is higher (6.0%, OR=10.0, P=0.004) in the subcohort of people without a higher education degree.
Improvements in Simulations for Radiotherapy Wedge Filter dose and AAA-Convolution Factor Algorithms
Authors: Casesnoves Francisco
Published: July 2019

Analytical-convoluted and numerical Gaussian models have been used in recent decades for radiotherapy treatment planning software/calculations, to perform accurately radiation dose delivery –numerical, analytical, or numerical-analytical. The objective of this evoluted-contribution was to obtain an exact dose delivery, 3D analytical-integral-equation solution, for the triple Gaussian model of wedge filters, since previous/initial 2D approximations of other authors, although correct, were not completely exact. Additionally, to set conceptual and mathematical-geometrical differences between the beam modification created by Multi-Leaf Collimator and Wedge Filters, either standard or Conformal. Ever the precision, from mathematical theory algorithms to real laboratory measurements, a series of simulations are presented. The generic triple Gaussian model of Ulmer and Harder sets an Attenuation Exponential Factor, AEF, well approximated in 2 variables, namely, u and z. This evoluted contribution of the research contribution was specially focused on numerical methods and approximation analysis of the integral equation resolution –with extent details about numerical data, Appendix 3. In this paper we set a detailed spatial-spherical geometry discussion/proof towards the determination of a 3D integral form of the delivery dose in water. In other words, with an AEF for magnitude-values of variables u,v, and z. Simulations, based on these new determinations were shown with sharp presentation of the numerical-computational software and functional programming series development. Computing encode techniques are explained with some practical examples for numerical radiotherapy calculus.
浅谈水泥稳定碎石基层裂缝防止与处置方法
Authors: 王 文宇
Published: July 2019

目前,我国大多数公路建设基层均采用水泥稳定碎石结构,但其容易产生裂纹和裂缝,本文结合笔者在建设过程中的工程实践,深入分析总结了引起水稳基层裂缝的内因和外因,对水稳基层裂缝形成的机理进行了详细分析,提出从材料控制、施工控制等方面控制基层裂缝的产生,并针对已经出现的基层裂缝提出了行之有效的处理措施。
探析装配式建筑用预制构件生产线和生产工艺
Authors: 宋 治刚
Published: July 2019

本文重要介绍了装配式建筑的发展历程,并结合工程实例,详细介绍了装配式建筑使用的预制构件的生产线及生产工艺,旨在为业内人士提供有价值的参考意见。
水利水电工程现场安全施工管理措施探讨
Authors: 旷 新建
Published: July 2019

社会的迅速发展与建设使得我国人民的生活质量不断提高,国民经济处于持续增长阶段,水利水电等基建工程建设规模日益增大,施工技术难度系数也越来越大,对工程建设质量提出了更高的要求。作为在中国经济社会发展的水利水电工程的重要基础设施,施工质量和安全问题开始受到越来越多的关注,以及安全管理的水利水电工程施工涉及人民生命和财产安全的重要方面。文章对水利水电工程施工现场安全管理进行了分析,然后对水利水电工程施工现场安全管理过程中存在的主要问题进行了分析,昀后提出了相应的解决措施。
电力自动化中智能无功补偿技术的应用研究
Authors: 陆 耀超
Published: July 2019

随着生产生活对用电要求越来越高,当前的电力系统已经很难满足电力资源的优化配置和电力管理的高要求。我国生产生活中使用的大多数设备都需要消耗电力,电力能源成为保障正常生产生活和经济持续发展的必备条件。智能无功补偿技术在电力自动化领域有着重要的应用价值。该技术的出现解决了电力输送中电压不稳定的问题,有效提升了电力自动化水平。文章针对智能无功补偿技术在电气工程自动化中的应用展开讨论,并提出合理化建议。
市政施工中地下管线施工技术论述
Authors: 陈 涛
Published: July 2019

随着我国经济的不断发展,我国各领域建设和设施也逐步完善,但极个别部分还存在一定的问题,比如市政工程建设中地下管线施工当中,就存在一些局限性,因此,本文主要结合了市政工程建设中地下管线施工所存在的问题,进一步探究了其施工技术的关键点,力争在确保工程质量和施工人员人参安全的基础上,更好的促进我国城市化建设。
关于BIM建筑结构设计过程的研究与实现
Authors: 刘 友军
Published: July 2019

随着现阶段我国社会经济水平的不断提升,建筑行业的发展也已经进入到了一个新的阶段,社会经济的发展带动了建筑工程行业的发展,随着建筑数量的不断增加,其建筑工程规模也变得越来越大,在这样的时代背景之下,人们对于建筑工程的质量要求也变得越来越高。为了可以使工程建设的质量得到有效保证,更多的科学技术开始在建筑工程中进行应用。对于工程项目建设而言,建筑结构的设计是其中重要的组成部分,同时也是施工活动展开的根本。相关设计工作人员的思想意识应该与时俱进,不断对设计理念进行创新以及改变,综合考虑建筑工程的实际需求情况来展开设计工作,同时还应该重视对工程项目经济效益的提升。随着我国科学技术水平的不断提升,其在建筑工程行业中的应用力度也越来越大,受到了业内人士的广泛欢迎。BIM技术就是其中昀具有代表性的例子,基于此,本文对关于BIM建筑结构设计过程的研究与实现进行了探索分析。
工民建施工中混凝土浇筑施工技术应用研究
Authors: 周 志辉
Published: July 2019

如今,我国的建筑行业取得了有目共睹的成绩,同时人们对工民建工程的需求也随之增多。在工民建施工体系中,混凝土浇筑发挥着至关重要的作用,且混凝土浇筑施工水平也直接决定了整体工程质量。基于此,本文围绕工民建施工中混凝土浇筑施工技术的实践应用展开了探究。
智慧城市的测绘地理信息服务模式分析
Authors: 林 韬略
Published: July 2019

近年来,随着我们国家的测绘地理信息在整个城市建设中的广泛应用,我们将测绘地理技术不断地应用到城市建设中,以社会经济产业的加速发展来完善智慧城市建设的重要途径。在智慧城市建设中,构建城市基础地理信息平台,建立准确、动态、高效的共享型数据平台,全面实现空间数据共享,实现由传统地图制图向综合地理信息服务转变,是城市可持续发展、信息化管理的迫切需要。测绘地理信息技术所发挥的作用就是不同忽视的,对于相应的服务模式进行研究非常必要。本文针对面向智慧城市的测绘地理信息服务模式进行探究。
建筑工程绿色施工技术应用研究
Authors: 李 国水
Published: July 2019

当前我国大力推行的科学发展观对于建筑工程建设提出了更高更为严格的要求,绿色施工技术受到更高的重视。在具体进行建筑工程建设的时候,有效应用绿色施工技术与时代发展相符,该技术的有效应用有效促进了人类社会和环境之间的和谐发展。对于现代建筑企业来说,绿色施工技术及其技术管理,直接影响着企业未来的发展状态。本文主要就建筑工程中绿色施工技术的内涵、主要内容、特点、意义以及实际应用等进行论述。
建筑电气工程低压电气安装施工要点探微
Authors: 程 晨
Published: July 2019

低压电气即在交流电压1200V以下、直流电压1500V以下的电气设备,是低压系统中控制、配电、保护线路及其他电气设备的重要电子元器件。因此为了充分发挥其在建筑工程中的作用,本文阐述了建筑电气工程中的低压电气安装施工特点及其施工要求,对建筑电气工程低压电气安装施工要点进行了探讨分析。
DETERMINAN KEJADIAN COMPOSITE INDEX OF ANTHROPOMETRIC FAILURE (CIAF) DI KABUPATEN SIJUNJUNG, PADANG PARIAMAN DAN PASAMAN BARAT
Authors: Fitri Refliny Yulia
Published: July 2019

Composite Index Of Anthropometric (CIAF) is a tool to measure nutrition, especially to identify children with several anthropometric failures. From WHO data estimates 52 million children under 5 years are thin, 17 million people are very thin and 155 million are short, while 41 million people are obese. About 45% of deaths among children under 5 years of age are related to malnutrition. The aim of the study was to determine the incidence of Composite Index of Anthropometric (CIAF) at the age of 24-59 months in Sijunjung District, Padang Pariaman and West Pasaman.

This type of research is quantitative with Cross Sectional research design conducted in May-August 2018. The research population amounted to 9,164 children from three districts namely Sijunjung District, Padang Pariaman and West Pasaman. Samples in the study of children aged 24-59 months with a total of 267 children. The analysis used is univariate, bivariate and multivariate analysis.

The results of this study using logistic regression for the most dominant factors influencing the CIAF event, namely the family economy with P value 0,000 (OR 10,503).The conclusion of this study is that of the three districts that influence the incidence of CIAF are the maternal education and family economy. Posyandu cadres are expected to better monitor the health of the field so that children can report nutritional problems in more detail.

 
The Effectiviness Of Kangaroo Mother Care On Body Temperature Stability Of Low Birth Weight Infants At The Perinatology Room Dr. Achmad Mochtar Hospital Bukittinggi
Authors: Hendayani Weni Lidya
Published: July 2019

Low Birth Weight (LBW) is a baby with a birth weight less than 2500 grams regardless of gestation. The one of complication  is body temperature instability, and to maintain it, the infants are exposed to the Kangaroo Mother Care (KMC) Method. Data WHO and UNICEF in 2013 with 22 million baby birth in the world, where 16 % birth with low birth weight infants. The purpose of this study was to determine the effect of implementation kangaroo mother care on body temperature stability of low birth weight infants at the perinatology room Dr.Achmad Mochtar Hospital Bukittinggi. This research is a Pre-Eksperimental with one-group pretest-postest design in Agust 2018 as many 15 respondents with accidental sampling technique. The statistical test used is dependent T-test. The result of statistical test show a significant influence between body temperature stability before and after implementation kangaroo mother care with p-value = 0,000 (α ≤ 0.05). So it can be concluded that there is a relationship of The Effectiviness kangaroo mother care on body temperature stability of low birth weight infants. Suggestions to hospital can implementation kangaroo mother care because this method an effective, simple, and cheap method to care low birth weight infant.

Kata Kunci   : Kangaroo Mother Care, Body Temperature
DESKRIPSI PENERAPAN PATIENT SAFETY PADA PASIEN DI BANGSAL BEDAH
Authors: Kartika Imelda R
Published: July 2019

Rumah sakit merupakan salah satu sarana pelayanan kesehatan yang bertujuan untuk pemulihan dan pemeliharaan kesehatan yang lebih baik. Patient safety merupakan prioritas utama untuk dilaksanakan di Rumah Sakit dan hal itu terkait dengan isu mutu dan citra Rumah Sakit. Penelitian ini bertujuan untuk mengetahui penerapan patient safety di bangsal bedah RSUD DR. Achmad Mochtar Bukittinggi. Penelitian ini menggunakan desain penelitian kuantitatif dengan pendekatan deskriptif analitik dengan tujuan menganalisa hasil persepsi pasien tentang manajemen penerapan patient safety oleh perawat. Sampel sebesar 167 orang diambil menggunakan accidental sampling, dengan kriteria inklusi adalah pasien yang telah dirawat minimal 3 hari di ruangan agar terlihat bagaimana perawat menerapkan patient safety. Analisis data yang digunakan adalah analisis univariat dan analisis bivariate menggunakan uji chi-square. Hasil penelitian didapatkan 104 responden (62%) mengatakan dengan manajemen patient  safety tinggi. Berdasarkan hasil penelitian dapat disimpulkan bahwa penerapan patient safety  oleh perawat di ruang bedah yang paling baik dilakukan adalah dalam hal memberikan lembar persetujuan sebelum melakukan tindakan operasi dengan mean 3,90 (range 4), dimana hal ini penting dilakukan sebagai bentuk inform concent bagi pasien. Diharapkan rumah sakit dapat mempertimbangkan manajemen penerapan patient safety sebagai rujukan sehingga perawat dapat bekerja secara optimal.

 

 
Effect of Social Responsibility on Management by Value
Authors: Mohammad Majeed Mohsen , Al-shmary May Hmmodi
Published: July 2019

The research aim is to know the effect of social responsibility on the value university's leadership in light of research's problem ,which representative presented in management risk when there isn't social responsibility, this was presented in following question:

What is the extent of the effect of social responsibility by its two dimensions(economic and discretionary) on the Management by value in collage's Depts. ?

The research 's hypotheses' explained there was significant existing effect of social responsibility on the Management by values

Depending on (SPSS 20) program to measure the effect of social responsibility through its dimensions : discretionary ,ethical ,legal, economic , on the Management by value through its dimensions(survival, Ethical, wellbeing),the research achieved to existing of significant effect of social responsible by its two dimensions(economic and discretionary) on the management by variables and recommended to promote the values of the three dimensions and Devoting the concept of social responsibility through the quality units in collages by adopt seasonal evaluation of extent of social responsibility of departments synchronize with studies periods and establishing social responsibility prize to create competition .
Exploring Readiness Oof Iraqi Universities To Achieve The Quality Of Sustainable Education According To (Quacquarelli Symonds) QS Standards
Authors: Al Hassani Kamal Kazem , Shanein Diaa Abdel Sattar
Published: July 2019

This study sought to address a vital issue for Iraqi universities regarding their readiness to implement QS (Quacquarelli Symonds) standards to enhance the quality of sustainable education by focusing Iraqi universities on issues that increase their readiness to improve their educational quality indicators and QS World University Rankings ®). These criteria cover six main areas: academic reputation, employer review, teaching citations, faculty ratio compared to students, international students, and international professors. The researchers conducted a series of structured interviews for a number of faculty members, senior leaders and committees formed at the University of Al-qadissiyah and Al-Muthanna University for the purpose of determining the critical criteria for QS ranking, in which the ranking of the two universities can be improved according to the above standard. The current research found a set of conclusions and recommendations, in order to support its initiative to achieve outstanding levels of educational quality according to the QS ranking, the human resource in Iraqi universities, represented by the professors and teaching staff of the university, needs training and academic improvement in the field of global publishing as well as improving the English language. The most important recommendations were the establishment of training courses and workshops to promote the global academic publication and improving professors and teaching staff's English language as they affect 60% of the degree of the QS academic reputation and the citations.
The Impact Of Senior Management In The Application Of Quality Management
Authors: Ibrahim Khaled Abdullah
Published: July 2019

Since the emergence of the world in the era of the first industrial revolution, and since the human relations took the nature of dealing between companies of different nationality from the countries of the world, and with the intensity of dealing with various facilities and technologies, and the resulting enormity of the quality and quality of different products, and with the intensification of competition between companies and countries, And the growing desire to dominate the local and global markets, which increased its motto, the world witnessed the economic crises and the repercussions of some advanced industrial countries, and the emergence of new centers of gravity of the industrial technology countries were Japan, Korea and Southeast Asian countries and other countries that have added an element For innovation in industrial technology to the global competition circuit.

Hence, the factors and conditions of quality were reviewed and accelerated in accordance with the tastes of customers and the economic price, which imposed its importance based on many data. And the emergence of the comprehensive quality control system or the so-called international standards ISO 9000, all aimed at the liberalization of trade and the development of specific standards for trade, service and commodity.

Taking into consideration all of the above, as well as the growing interest in industry in developing countries, including the Arab countries, and their attempts to innovate in industrial catching up, the international standards have become very important in all developing countries.

Therefore, quality management in educational institutions has been addressed in some of its systems in order to shed light on this issue and to link it with the role of senior management. The concept of TQM has become an effective administrative approach adopted by most organizations. Since TQM in its essence and philosophy, Of its main and important tools and because it is the cornerstone in the management of the quality of the educational service, in which the service was received and developed following scientific methods based on the objective basis for both continuous improvement and quality management service.
Adapting The Outputs Of Education And Training To The Actual Needs Of Reality And Aspirations
Authors: Mohammed Al-Saadi Mohammed Jassim , Abdel Sayed Abdel Fattah Hassan
Published: July 2019

The human element is the main pillar in the implementation of economic development programs, and therefore the countries have been keen to take care of its rehabilitation within the human resources development progress programs focused mainly on educational curricula.

      Education and training has become an effective and influential tool in the science of development, since the human element is the means and purpose of the movement of progress and development. Countries are comparing and measuring their progress not with their natural resources and wealth in the ground or outside, but measured by their ability to exploit these resources to meet the requirements Its population. As an example, a country like Japan does not possess natural resources such as oil, gas or gold, and it does not have important agricultural resources, but possesses the educated and qualified human element that enabled it to be one of the most advanced countries. Despite its natural wealth, its human wealth and quality have been at the core of its growth and progress. Our country is characterized by a wealth of human resources and, in particular, a high proportion of young people compared to direct countries, It puts pressure on resources to productive energy by developing their productive capacities and competencies and providing them with the skills, expertise and renewable knowledge through continuous training.

      The lack of coordination between the quality of the outputs of education and vocational and technical training and the skilled requirements of the labor market, and the lack of attention and awareness among graduates towards self-employment through the establishment of small enterprises due to the lack of guidance and guidance, the low levels of skills and lack of funding, And to activate and activate the role of the private sector in terms of effective partnership in the effective governance of the system of vocational and technical education and training or in the management of the vocational training system.

      Today, we face a great challenge to adapt ourselves in the face of the urgent and imminent economic changes represented by the fall of customs barriers, borders and the ease of labor mobility. Recent global developments, developments in the economic arena, and the global markets have caused serious disruptions and severe recession, Change the economic outlook and keen attention to local economic conditions and self-reliance to the maximum degree to get out of the cycle of loss between the welfare of the major countries.

     It has been proven from the practical reality that relying solely on education is not enough for the graduates to meet the requirements of the jobs and professions that the labor market needs. This requires training as a means to meet the skills required to practice professions and jobs, especially if it is planned and designed by closely linking to the reality of the market the work .
Analysis Of The Relationship Between Academic Freedom And Organizational Loyalty
Authors: Mohsen Majed Abdel Amir , Mutab Hamid Kazem
Published: July 2019

The aim of this research is to analyze the relationship between academic freedom and organizational loyalty, as recognized by faculty members in the Faculty of Management and Economics, Al Qudsiyah University. And to test the significance of differences regarding the exercise of academic freedom by scientific title and gender. A questionnaire was designed for this purpose, which included two axes: academic freedom and organizational loyalty. It included (45) paragraphs to measure the exercise of academic freedom and the organizational loyalty of the college teachers and the relation between the two variables. The study found that there is a relationship between academic freedom and organizational loyalty in general. It also emerged that there is an acceptable level of academic freedom and good organizational loyalty to teaching the college, although there was no significant statistical relationship between some variables of academic freedom and organizational loyalty. Some proposals were presented, including the involvement of teachers in the selection of administrative leaders in the college, providing financial support for scientific research, participation in foreign scientific conferences and their participation in the decisions of appointing new teachers in the scientific department
The Impact of Islamic Finance in Promoting Education for Sustainable Development
Authors: Hamoudi Haidar , Hadi Zainab , Abdul Rahman Salam
Published: July 2019

The world is witnessing major changes in the vision and approach of higher education and its educational and research orientations. These changes have been in response to global developments and developments that have changed many concepts and attitudes towards higher education. According to this vision, the current research aims to identify the possibility of abandoning the civil education in Iraq from the traditional perspective aimed at education and scientific research and turning to the modern perspective which works to build an integrated system to reach the approach of sustainable development in education by focusing on the environmental,

The transformation of education from a traditional perspective to a modern perspective based on sustainable development requires an increase in its capabilities and capabilities. Therefore, educational institutions need to increase their sources of funding and resort to Islamic finance as one of the main sources of funding.                                                                              

In order to achieve the objectives of the research, a questionnaire was designed to show the extent to which Islamic banks have access to the funding structure of the faculties of Islamic studies (Islamic University, Al-Sheikh Al-Tusi College, Al-Kafeel College). The questionnaire was distributed in full, (Spss, v.15), where the results showed a relationship of correlation and effect between the variables of the study. The study also examined the size of the financial qualifications for the Islamic banking sector to enter the field of financing private education. The financial analysis was conducted for a sample of banks which reached (6) banks and over a period of time (2013-2016). The study reached a number of conclusions, the most important of which is that the Islamic banks sample study has the qualifications, capabilities and sufficient resources to enter as a partner or lender to the sector of civil education.
Role Of Managerial Leadership Skills In Enhancing Career Commitment
Authors: Hama Saeed Fayan Sulaiman , Owmar Sherwan Omar , Sadek Zana Majeed
Published: July 2019

The current research aims at identifying the role of managerial leadership skills (mental / intellectual skills, human skills, and managerial skills) in enhancing functional commitment (emotional / emotional commitment, normative commitment, continuous commitment) Erbil in the Kurdistan Region of Iraq. To achieve the goal, a questionnaire was constructed consisting of (30) question distributed to a sample of (39) single and was returned (30) form were all valid for analysis. The research found a relationship between the skills of the administrative leadership and the enhancement of the functional commitment, and the impact of the skills of the administrative leadership in enhancing the functional commitment. Accordingly, the research presented a set of recommendations and proposals, the most important of which is the need to increase attention to management skills to encourage and strengthen them In particular, the results of the field research showed the high level of these skills in the organization in question
EvaluatingThe Reality Of Applying Social Responsibility According To Some Personal Variables For Employees Of Some Scientific And Humanitarian Colleges At Mosul University
Authors: Ahmed Mayson Abdullah , Alsaraf Saja Natheer
Published: July 2019

The purpose of the research is to diagnose the extent to which the respondents in the field are aware of the importance of applying social responsibility, as well as the extent to which there are significant differences in the employees' understanding of the importance of applying the principles and the relationship between some personal variables (experience, educational level, A questionnaire was developed and distributed to a sample of workers in the field. The research reached the following results:

- The results of the research showed that respondents in the field are aware of the importance of applying the principles of social responsibility. The results showed high levels of awareness of all principles.

- There is a significant difference in the perception of the field workers concerned about the importance of applying social responsibility due to some demographic variables (experience, educational level)

- The study showed a statistically significant relationship with the application of social responsibility due to the demographic variables (experience, educational level, job level).

- Based on the results of the research, a number of recommendations and suggestions were presented, including the need to continue to support the senior management and its commitment to the implementation of social responsibility, in addition to embedding these principles in their organizational culture.
Giving Lemna Minor and Mud to the Growth of Tubifex sp.
Authors: Mahendra Mahendra , Damara Doni , Nufus Mursidatun , Putri Vira Riana
Published: July 2019

This study aims to determine the effect of the use of a combination of lemna minor substrates and mud on the biomass of the population of Tubifex sp. This research is experimental, with a completely randomized design (CRD), with five levels of treatment P1 = 100% (lemna minor ) + 2,000 gr (mud), P2 = 75% (lemna minor ) + 2,000 gr (mud), P3 = 50 % (lemna minor ) + 2,000 gr (mud), P4 = 25% (lemna minor) + 2,000 gr (mud), P5 = 0% (lemna minor) + 2,000 gr (mud). Data obtained from research results in analysis of variance (ANOVA) and in further testing with the Smallest Significant Difference test. The main parameters observed were the number of population and biomass of Tubifex sp. The results of the study showed that the combination of Lemna minor substrate and mud significantly (p <0.05) on the growth of biomass and the population of Tubifex sp. The best results were found in the treatment with the treatment formulation P1 = 100% (lemna minor ) + 2,000 gr (mud) which produced a population of 6,250 ind / gr and biomass 8.60 gr / m2.
Related Knowledge and Support Family Mother Pregnant Women Attitudes about Prenatal Care (ANC)
Authors: Aritonang Dor Valda A , Adiwijaya Saputra , Wulandari Anggun , Anita D Nyoman
Published: July 2019

Antenatal care is a service provided to mothers in the process of pregnancy and to provide assurance that the mother and fetus are safe in pregnancy and childbirth. In the 2013 Riskesdas, the coverage of antenatal care for pregnant women increased.However, the coverage of K1 and K4 in East Java still has not reached 100%. The purpose of this study was to determine the mother's knowledge and family support for the attitudes of pregnant women regarding ANC in the work area of Gunung Anyar Public Health Center, Surabaya City. This study used a cross sectional study design. The population was 1089 pregnant women and samples were taken using the Slovin formula of 75 people. The statistical test used is Chi Square test with a confidence level of 95%. The results show that pregnant women who have poor knowledge of 46 people (61.3%), pregnant women who get less family support are 28 people (37.3%), and pregnant women who have a negative attitude about ANC of 42 people ( 56.0%). The p-value between mother's knowledge and family support with the mother's attitude about ANC is 0.012 and 0.744. The conclusion is that there is no relationship between maternal knowledge and family support with the mother's attitude about ANC.