bluuebunny/crossref_metadata_2025 huggingface dataset:
How much control do firms exercise over their resources when entering emerging markets? The influence of institutional voids on entry mode degree of control
Authors: Giachetti Claudio , Peprah Augustine Awuah
Published: July 2020

The international management literature has presented inconclusive results about the effect of institutional voids in a host country on entrant firms’ resource commitment. With the lens of institutional theory and transaction cost theory, this article examines how institutional voids in an emerging market influence a firm’s decision to move resources in that market. Resource commitment in an emerging market is examined in terms of the degree of control of the entry strategy employed. The theory presented argues that as institutional voids in a firm’s host country escalate, the firm sets out different priority actions to mitigate behavioral and environmental uncertainties in the host country, that in turn affect the degree of control of its entry modes. By relying on a sample of 90 Italian firms operating in China between 2001 and 2010, the results support the hypothesis that the institutional voids–entry mode degree of control relationship displays an inverted U-shape.

JEL CLASSIFICATION F23; L1
Correction to: Test-retest reliability of the computer-assisted DIA-X-5 interview for mental disorders
Authors: Hoyer Jana , Voss Catharina , Strehle Jens , Venz John , Pieper Lars , Wittchen Hans-Ulrich , Ehrlich Stefan , Beesdo-Baum Katja
Published: July 2020

An amendment to this paper has been published and can be accessed via the original article.
Correction to: Phylogeography of higher Diptera in glacial and postglacial grasslands in western North America
Authors: Solecki Anna M. , Skevington Jeffrey H. , Buddle Christopher M. , Wheeler Terry A.
Published: July 2020

An amendment to this paper has been published and can be accessed via the original article.
Clinical observation of two bone cement distribution modes of percutaneous vertebroplasty in the treatment of thoracolumbar Kümmell’s disease
Authors: Chen Ji-Bin , Xiao Ya-Ping , Chen Dong , Chang Jian-Zhong , Li Te
Published: July 2020

Background

In recent years, percutaneous vertebroplasty (PVP) has provided a new option for the treatment of Kümmell’s disease (KD). This retrospective study aimed to investigate the differences in clinical characteristics, clinical efficacy, and related complications between two types of bone cement distribution patterns in the PVP treatment of KD.

Methods

A total of 63 patients with KD from January 2016 to February 2018 who received PVP treatment were examined at least 24 months. According to X-ray distribution modes of bone cement after PVP treatment, they were divided into 2 groups: blocky group (30 cases) and spongy group (33 cases). Clinical features and disease severity preoperatively, and clinical efficacy and related complications postoperatively were statistically compared between the two groups.

Results

The two groups were followed for at least 24 months. The duration of disease, age, Cobb angle, and vertebral compression rate preoperatively were significantly higher in the blocky group than in the spongy group (P < 0.05, respectively). The height of vertebral anterior margin and BMD were significantly lower in the blocky group than in the spongy group (P < 0.05, respectively). The amount of bone cement injected was significantly greater in the blocky group than in the spongy group (P = 0.000). VAS and ODI of the two groups were significantly reduced at the first day, the first year, and the last follow-up postoperatively (all P = 0.000) and were maintained at the last follow-up. VAS and ODI postoperatively decreased significantly in the spongy group compared with the blocky group (P = 0.000). The correction degrees of kyphosis and vertebral compression postoperatively in the two groups were significantly corrected, but gradually decreased over time (P < 0.05), and these correction degrees were significantly higher in the blocky group than in the spongy group, and the postoperative losses were also more serious.

Conclusions

The disease was more serious in the blocky group than in the spongy group. The amount of bone cement, correction degrees of postoperative kyphosis and vertebral compression were significantly higher in the blocky group than in the spongy group, but its postoperative losses of the correction degrees of kyphosis and vertebral compression were also more serious. However, for pain relief and functional recovery, the spongy group was superior to the blocky group. Therefore, the spongy distribution pattern should be formed during the injection of bone cement to obtain better therapeutic effect.
Lessons learned from the mechanisms of posttraumatic inflammation extrapolated to the inflammatory response in COVID-19: a review
Authors: Teuben Michel P. J. , Pfeifer Roman , Teuber Henrik , De Boer Leonard L. , Halvachizadeh Sascha , Shehu Alba , Pape Hans-Christoph
Published: July 2020

Up to 20% of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) patients develop severe inflammatory complications with diffuse pulmonary inflammation, reflecting acute respiratory distress syndrome (ARDS). A similar clinical profile occurs in severe trauma cases. This review compares pathophysiological and therapeutic principles of severely injured trauma patients and severe coronavirus disease 2019 (COVID-19).

The development of sequential organ failure in trauma parallels deterioration seen in severe COVID-19. Based on established pathophysiological models in the field of trauma, two complementary pathways of disease progression into severe COVID-19 have been identified. Furthermore, the transition from local contained disease into systemic and remote inflammation has been addressed. More specifically, the traumatology concept of sequential insults (‘hits’) resulting in immune dysregulation, is applied to COVID-19 disease progression modelling. Finally, similarities in post-insult humoral and cellular immune responses to severe trauma and severe COVID-19 are described.

To minimize additional ‘hits’ to COVID-19 patients, we suggest postponing all elective surgery in endemic areas. Based on traumatology experience, we propose that immunoprotective protocols including lung protective ventilation, optimal thrombosis prophylaxis, secondary infection prevention and calculated antibiotic therapy are likely also beneficial in the treatment of SARS-CoV-2 infections. Finally, rising SARS-CoV-2 infection and mortality rates mandate exploration of out-of-the box treatment concepts, including experimental therapies designed for trauma care.
Good and sustained response to pembrolizumab and pazopanib in advanced undifferentiated pleomorphic sarcoma: a case report
Authors: Arora Shalabh , Rastogi Sameer , Shamim Shamim Ahmed , Barwad Adarsh , Sethi Maansi
Published: July 2020

Background

Conventional cytotoxic agents and pazopanib are approved for advanced soft tissue sarcomas but have low response rates and modest survival benefits. Recently, immune checkpoint inhibitors have shown clinically meaningful activity. The combination of pazopanib and immunotherapy has shown synergism in various other malignancies but has not been fully explored in advanced soft tissue sarcomas.

Case presentation

A 63 year old woman with metastatic undifferentiated pleomorphic sarcoma progressed after two lines of palliative combination chemotherapy—doxorubicin with olaratumab, and gemcitabine with docetaxel. In view of significant symptoms, she was treated with pazopanib in combination with pembrolizumab. She had remarkable radiological and clinical improvement, with a manageable toxicity profile and an ongoing response at ten months of therapy.

Conclusions

Undifferentiated pleomorphic sarcoma is an immunologically active subtype of soft tissue sarcoma, which is particularly amenable to immune checkpoint inhibitors. Pazopanib with immune checkpoint inhibitors is a well-tolerated, yet hitherto underexplored combination that may offer significant clinical benefit in advanced sarcomas—this finding warrants further evaluation in clinical trials.
Evaluation of maxillary sinus floor augmentation with the crestal approach and beta-tricalcium phosphate: a cone-beam computed tomography 3- to 9-year follow-up
Authors: Oba Yoko , Tachikawa Noriko , Munakata Motohiro , Okada Tsuneji , Kasugai Shohei
Published: July 2020

Background

We performed maxillary sinus floor augmentation using the crestal approach and beta-tricalcium phosphate (β-TCP) and a long-term evaluation using cone-beam computed tomography (CBCT).

Methods

Twenty-three patients (30 implants) underwent sinus floor augmentation using the osteotome technique. Subjects underwent CBCT imaging before surgery, immediately after surgery, and at follow-up (≥ 3 years after surgery). We measured the changes in height of the augmented sinus floor (SL), the augmented bone above apex of the implant (BH), and the implant length that projected into the sinus (IL).

Results

The mean SL decreased from 6.54 ± 1.51 (immediately after surgery) to 3.11 ± 1.35 mm (follow-up). The mean BH decreased from 3.17 ± 0.97 to − 0.25 ± 1.19 mm; the maxillary sinus floor in many implants was near the apex at follow-up. The SL at follow-up showed a strong correlation with the IL (p = 0.0057).

Conclusions

Osteotome sinus floor elevation with beta-tricalcium phosphate was clinically effective. Cone-beam computed tomography analysis revealed that ≥ 3 years after surgery, the maxillary sinus floor was near the apex of the implant.
Wyznaczanie okręgów wyborczych we francuskiej tradycji ustrojowej
Authors: Stolicki Dariusz
Published: July 2020

Designing Constituencies in the French Political Tradition The article analyzes the French redistricting process (redécoupage) since 1789, tracing both the evolution of relevant legal norms through the transformations in the political regime and the electoral system, and the actual political practice – what were the driving forces behind consecutive redistrictings, how the districting rules and district boundaries themselves were manipulated for partisan and individual political gain, and how did the resultant district maps measure against standards such as electoral equality and political neutrality. The article concludes that while the French redistricting process remains highly politicized when compared with other European countries, the 2008 constitutional reforms and the changes resulting from them were substantial steps towards greater transparency. Moreover, there is no persuasive evidence that recent redécoupages were systematically manipulated for political purposes by the governing parties.
Dysfunctional democracy vs. direct representation
Authors: Coleman Stephen
Published: July 2020

The challenge democratic politics face at the moment is not how to preserve its pristine stability from radical disturbance, but how to salvage its most fundamental norms from the prevalent drift towards authoritarianism, populism and xenophobia. If there is to be an effective salvage operation, democracies must be open to radical reconfiguration – perhaps even re-invention. To realize this opportunity, however, entails confronting the fundamental mismatch that exists between governmental logic and the increasingly embedded practices of socially networked citizens. This entails drawing upon the fullest range of interactive features of the current media ecology in order to establish a permanent and ongoing conversation between representatives and the citizens they represent, while at the same time facilitating lateral interaction between citizens and between decision-making institutions and those most likely to be affected by their decisions.
Em nome do pai
Authors: Venancio Rafael , Fulaneti Oriana de Nadai
Published: July 2020

A liberdade de aprender e ensinar é uma garantia consagrada pela Constituição Federal de 1988. Apesar disso, não raro, encontramos tentativas que buscam suprimir essa garantia constitucional por meio da força impositiva do Estado. É o caso da decisão judicial, tomada por uma desembargadora do Tribunal de Justiça de Santa Catarina, em que se permitiu que a deputada estadual Ana Caroline Campagnolo mantivesse seu canal informal de denúncias contra professores doutrinadores. Na decisão, a magistrada relatora não vislumbra ilegalidades na conduta da parlamentar. Nesse contexto, nossa pesquisa, numa conexão entre a Análise do Discurso francesa e o Direito, pretende investigar, no corpus em cena, as marcas discursivas presentes no texto decisório que levam a inferir que a decisão em tela coaduna-se com as ideologias que caracterizam o governo do presidente Jair Bolsonaro e, no limite, incentivam que se vigie e puna professores por expressarem resistência à nova ordem política.
Thyrotoxicosis in patients with COVID-19: the THYRCOV study
Authors: Lania Andrea , Sandri Maria Teresa , Cellini Miriam , Mirani Marco , Lavezzi Elisabetta , Mazziotti Gherardo
Published: July 2020

Objective:

This study assessed thyroid function in patients affected by the coronavirus disease-19 (COVID-19), based on the hypothesis that the cytokine storm associated with COVID-19 may influence thyroid function and/or the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may directly act on thyroid cells, such as previously demonstrated for SARS-CoV-1 infection.

Design and methods:

This single-center study was retrospective and consisted in evaluating thyroid function tests and serum interleukin-6 (IL-6) values in 287 consecutive patients (193 males, median age: 66 years, range: 27–92) hospitalized for COVID-19 in non-intensive care units.

Results:

Fifty-eight patients (20.2%) were found with thyrotoxicosis (overt in 31 cases), 15 (5.2%) with hypothyroidism (overt in only 2 cases), and 214 (74.6%) with normal thyroid function. Serum thyrotropin (TSH) values were inversely correlated with age of patients (rho −0.27; P < 0.001) and IL-6 (rho −0.41; P < 0.001). In the multivariate analysis, thyrotoxicosis resulted to be significantly associated with higher IL-6 (odds ratio: 3.25, 95% confidence interval: 1.97–5.36; P < 0.001), whereas the association with age of patients was lost (P = 0.09).

Conclusions:

This study provides first evidence that COVID-19 may be associated with high risk of thyrotoxicosis in relationship with systemic immune activation induced by the SARS-CoV-2 infection.
Análisis cuantitativo, uso de Escala Braden por enfermería en el servicio de Medicina Interna del Hospital Santo Domingo
Authors: Rodríguez  Díaz Jorge Luis , Cobos Echeverría Daniel Fernando , Romero Salas Patricia Jennifer , Parcon Bitanga Melynn
Published: July 2020

El objetivo de este estudio fue evaluar, mediante un análisis cuantitativo, el uso y aplicación de la Escala de Braden por el personal de enfermería en pacientes de medicina interna del Hospital Santo Domingo, año 2018. Es un estudio cuantitativo, transversal y descriptivo; la población total fue de 1017 pacientes con una muestra de 30 (12 masculinos y 18 feminas), ingresados al área de medicina interna del Hospital General Santo Domingo, provincia Santo Domingo de los Tsáchilas, de julio a agosto del 2018. Se les realizó una revisión de su historia clínica para conocer el puntaje que determinaba el riesgo de desarrollar úlceras por presión (UPP), según la valoración que recibieron mediante la escala. Durante la aplicación de la Escala de Braden, se pronosticó riesgo bajo a 15 pacientes, riesgo medio a 10 y riesgo alto a 5, quienes presentaron alteraciones neurológicas o enfermedades crónicas como: accidente cerebrovascular, diabetes mellitus, cirrosis hepática. Se concluye que el personal de enfermería no realiza una aplicación adecuada de la Escala de Braden ni desde el ingreso del paciente ni durante su reevaluación en el servicio de medicina interna, lo que trae consigo que la atención no se realice con la calidad requerida. Factor favorable para complicaciones como las UPP.
Algunos problemas prácticos de traducción relacionados con el concepto de “traducción filológica” (en el ejemplo de la traducción de las obras de C. Simon del francés al ruso)
Authors: A. G Vishnyakov , O. A Kasatkina , S. V Maslechkina , N. A Filatova , N. A Ivanova
Published: July 2020

El propósito de este trabajo es presentar una hipótesis sobre la “traducción filológica” de textos literarios de mayor complejidad y probarla en el material de obras específicas. Basado en el material de los estudios de traducción rusa y extranjera, el documento formula el concepto de "traducción filológica" en el apéndice de un proyecto editorial específico dentro de la serie "Monumentos literarios" publicada por el Instituto de Literatura Mundial de la Academia de Ciencias de Rusia, y considera los aspectos prácticos más importantes del problema de la traducción adecuada de textos literarios de mayor complejidad. El análisis de la traducción de dos obras por el representante de la Nueva Novela francesa Claude Simon ilustra claramente el ejemplo de una “traducción filológica”. En el curso del estudio, los autores llegaron a la conclusión de que una traducción filológica implica una apelación a un texto que es clásico en su riqueza, complejidad y significado en la literatura mundial. El potencial comercial de traducir un texto de este tipo no es obvio y requiere que el editor renuncie a la rentabilidad a corto plazo, que el traductor renuncie al trabajo de rutina que se ajusta a un marco de tiempo predeterminado y que el lector deje de centrarse en lo no problemático (no conflicto, sin complicaciones), lineal, lectura / consumo de una sola vez del libro a favor de volver a leer / saborear.
Group-Based Micro-Borrowers Social Space Development Policies in Bangladesh
Authors: Rouf Kazi
Published: July 2020

This policy brief looks at Grameen Bank (GB) microcredit sixteen Decisions policies to examine the degree to which women borrowers of the Grameen Bank are empowered to participate in familial decision-making around the management of income and expenditures, and to examine women borrowers’ engagement in community activities. This policy brief is based on previous GB microcredit research conducted by the author. results show that GB policies have resulted in the increased participation of women in households and communities, but also show a movement toward development. Using the case of Bangladesh, this policy brief recommends that GB should include gender equality in its sixteen Decisions to address the role of women.
Avant-Propos/Foreword
Authors: Dunton Caroline
Published: July 2020

I am happy to introduce the Fall 2015 edition of Potentia, which is the 6th publication of the Centre forInternational Policy Studies’ (CIPS/CEPI) graduate studies journal.
Food Security and Climate Change in Sub-Saharan Africa
Authors: McGowan Chase
Published: July 2020

Climate change is predicted to have a detrimental impact on food security throughout the world, but the poorest regions are likely to be the most affected. The Food and Agriculture Organization identifies four aspects of food security: availability, access, stability and utilization. This literature review examines the predicted impacts of climate change on food security in Sub-Saharan Africa. First, an analysis of the scientific literature was undertaken to investigate the potential impact of climate change on each of these four aspects. Second, policies relating to food security and climate change of key UN bodies, international non-profit organizations, and national governments in Sub-Saharan Africa were examined. Overall, there is extensive evidence that climate change will negatively impact each of the four aspects of food security in Sub-Saharan Africa. Until now, international organizations and national governments have failed to adopt comprehensive policies to adapt to climate change. To be effective, efforts to address the problem should combine social and development aspects.
ToC
Authors: CIPS
Published: July 2020

ToC
La historia como estado de excepción continuo: Sefarad, de Antonio Muñoz Molina
Authors: Arroyo-Rodríguez Daniel
Published: July 2020

En su novela Sefarad (2001), Antonio Muñoz Molina hace partícipe al lector de los procesos de exclusión que experimentan aquellos individuos que, como consecuencia del Holocausto, la guerra civil española (1936-39) o el terror estalinista, son arrollados bajo los engranajes de la historia. Para ello, Muñoz Molina involucra al lector en un diálogo mutuamente informativo entre presente y pasado con el propósito de preservar la memoria, de hacerla relevante para un lector contemporáneo y de incluir a este último dentro de un contradiscurso que se concibe fuera del marco social y totalizador de la historia.
ȻENTOL TŦE TEṈEW̱ (TOGETHER WITH THE LAND)
Authors: Mowatt Morgan , De Finney Sandrina , Wright Cardinal Sarah , Tenning Jilleun , Haiyupis Pawa , Gilpin Erynne , Harris Dorothea , MacLeod Ana , XEMŦOLTW̱ Claxton Nick
Published: July 2020

This article presents reflections from an Indigenous land- and water-based institute held from 2019 to 2020 for Indigenous graduate students. The institute was coordinated by faculty in the School of Child and Youth Care at the University of Victoria and facilitated by knowledge keepers in local W̱SÁNEĆ and T’Sou-ke nation territories. The year-long institute provided land-based learning, sharing circles, online communication, and editorial mentoring in response to a lack of Indigenous pedagogies and the underrepresentation of Indigenous graduate students in frontline postsecondary programs. While Indigenous faculty and students continue to face significant, institutionally entrenched barriers to postsecondary education, we also face growing demands for Indigenous-focused learning, research, and practice. In this article, Part 1 of a two-paper series on Indigenous land- and water-based learning and practice, we draw on a storytelling approach to share our individual and collective reflections on the benefits and limitations of Indigenous land- and water-based pedagogies. Our stories and analysis amplify our integration of Indigenous ways of being and learning, with a focus on local knowledges and more ethical land and community engagements as integral to Indigenous post­secondary education.
Endothelial Progenitor Cells are Increased in Patients with Advanced Pancreatic Cancer Treated with Gemcitabine and Intravenous Omega 3 Compared with Controls
Authors: Isherwood John , Arshad Ali , Chung Wen , Runau Franscois , Cooke Jill , Pollard Cristina , Howells Lynne , Fishwick Jenny , Thompson John , Metcalfe Matthew , Steward William , Dennison Ashley
Published: July 2020

Introduction Pancreatic adenocarcinoma (PAC) is a devastating disease. Endothelial progenitor cells (EPCs) are important mediators in PAC. Omega 3 fatty acids (ω-3FAs) have been shown to have anti-inflammatory properties. Methods This was a single centre study investigating intravenous ω-3FAs and gemcitabine chemotherapy versus gemcitabine therapy alone in patients with APC. The primary outcome measure was the level of EPCs with the secondary outcome measure being the relationship between the EPC levels, progression free survival and overall survival.Results Over the treatment period CD45-, CD31+, CD133+ EPCs and CD45-, CD31+, CD34+ EPCs significantly increased (P=O.O42 and P=0.0001), whilst no change was observed in control EPCs (P=0.705). There was a non-significant downward trend in control EPCs (P=0.930, 95%). There was a significant difference between the trial and control patients over time on logistic regression analysis (P=0.0001). There was a significant increase in CD45-, CD34+, CD31+ and CD133+ EPCs trial EPCs over treatment (P=0.007). There was no significant increase seen in control EPCs (P=0.358, 95%). There was a significant difference between the trial and control patients over treatment on logistic regression analysis (P=0.0001). There was a significant correlation in the trial patients between progression free survival benefit and an increase in EPCs.Conclusion Intravenous ω-3FAs with gemcitabine chemotherapy in APC results in a significantly increased level of EPCs. There appears to be a survival benefit in patients with an increase in EPCs which may be the result of a reduction in pro-inflammatory mediators.
Adolescent Obesity and its association with socio-demographic profile, lifestyle factors, dietary and physical activity patterns; findings from southwestern Nigeria
Authors: Adeomi Adeleye Abiodun , Olodu Monday Daniel , Yaya Sodiq , Ademiju Adediti , Ajibade Raphael
Published: July 2020

BackgroundThe prevalence of adolescent obesity is rising in all parts of the world, but only very few studies have considered factors influencing obesity among Nigerian adolescents. This study therefore aimed to determine the prevalence of obesity and its association with socio-demographic profile, lifestyle factors, dietary patterns and physical activity patterns among in-school adolescents in Southwest, Nigeria.MethodA total sample size of 400 in-school adolescents was selected through a multi-stage sampling technique from secondary schools in Ile-Ife. The dietary patterns were assessed using a 92-item QFFQ, while the activity patterns were assessed using the physical activity questionnaire for older children and adolescents. Data were analyzed using IBM SPSS.ResultThere were 211 (52.8%) males and 189 (47.3%) females, with mean ages of 14.8 ± 2.1 and 14.4 ± 1.9 years respectively. The prevalence of overweight/obesity was 12.8%, and the associated factors were age, sex, class, the number of children in the family, birth orders and the dietary pattern dominated by starchy foods, roots and tubers (p < 0.05). However, no significant relationship existed between adolescents’ obesity and lifestyle factors, as well as physical activity patterns (p > 0.05). After controlling for confounders, age, number of children and birth orders remained significant.ConclusionThe prevalence of overweight/obesity was relatively high among the respondents, and this was associated with the age, number of children in the family and the birth order of the adolescents. The findings of this study underscore the importance of family planning to the control of the obesity epidemic in Nigeria.
Microglial Cathepsin B and Porphyromonas gingivalis Gingipains as Potential Therapeutic Targets for Sporadic Alzheimer’s Disease
Authors: Nakanishi Hiroshi , Nonaka Saori , Wu Zhou
Published: July 2020

Many efforts have been made to develop therapeutic agents for Alzheimer’s Disease (AD)
based on the amyloid cascade hypothesis, but there is no effective therapeutic agent at present. Now,
much attention has been paid to infiltrate pathogens in the brain as a trigger of AD. These pathogens,
or their virulence factors, may directly cross a weakened blood-brain barrier, reach the brain and cause
neurological damage by eliciting neuroinflammation. Moreover, there is growing clinical evidence of
a correlation between periodontitis and cognitive decline in AD patients. Recent studies have revealed
that microglial cathepsin B is increasingly induced by lipopolysaccharide of Porphylomonas gingivalis,
a major pathogen of periodontal disease. Moreover, gingipains produced by P. gingivalis play
critical roles in neuroinflammation mediated by microglia and cognitive decline in mice. Furthermore,
an orally bioavailable and brain-permeable inhibitor of gingipain is now being tested in AD patients. It
is largely expected that clinical studies countering bacterial virulence factors may pave the way to establish
the prevention and early treatment of AD.
Genetic Management Algorithm in High-Risk Fabry Disease Cases; Especially in Female Indexes with Mutations
Authors: Sezer Ozlem , Ceylaner Serdar
Published: July 2020

Background:

Fabry Disease (FD, OMIM#301500) is a progressive, life-threatening, multisystemic,
rare lysosomal storage disease. Today, approximately 1000 mutations are recorded in the
Human Gene Mutation Database (www.hgmd.org) for GLA. Among the identified mutations, genetic
variants of unknown significance (GVUS) and novel mutations cause problems in terms of diagnosis
and treatment approach.

Methods:

In our study, 510 high-risk patients were enrolled. 229 out of 510 were Male (45%) (Mean
age was 40.8 ±15.0) and 281 of were Female (55%) (Mean age was 39, 7±15.5). The definite diagnosis
of the FD was confirmed by GLA gene sequence analysis. GLA mutation was found in 15 cases
(3.4%). Family members of the relevant indexes were included in the screening programs according to
the X-linked inheritance pattern. And then we conducted family screening on 74 family members of 15
index cases. Of those 74 cases, 39 had mutations (53%). In males, α-GalA activity and in both gender
Lyso-Gb3 levels were measured and multisystem evaluation was performed in all cases with the mutation.

Results:

We found six different familial mutation types; two of them pathogenic; p.D170N (1),
p.P205S (13), one of them GVUS; p.Q330R (1), three of them likely benign; p.D313Y (12), p.S126G
(25), c.-30G>A (2) mutations were detected.

Conclusions:

The purpose of this retrospective study is to approach Fabry disease on a genetic basis
and to improve its management and to draw attention to the importance of early diagnosis. We also
aimed to evaluate the appropriate algorithms to determine whether the mutation is the FD-causing mutation
or not.
Predictors of COVID-19 Information Sources and Their Perceived Accuracy in Nigeria: Online Cross-sectional Study (Preprint)
Authors: Erinoso Olufemi , Wright Kikelomo Ololade , Anya Samuel , Kuyinu Yetunde , Abdur-Razzaq Hussein , Adewuya Abiodun
Published: July 2020

BACKGROUND

Effective communication is critical for mitigating the public health risks associated with the COVID-19 pandemic.

OBJECTIVE

This study assesses the source(s) of COVID-19 information among people in Nigeria, as well as the predictors and the perceived accuracy of information from these sources.

METHODS

We conducted an online survey of consenting adults residing in Nigeria between April and May 2020 during the lockdown and first wave of COVID-19. The major sources of information about COVID-19 were distilled from 7 potential sources (family and friends, places of worship, health care providers, internet, workplace, traditional media, and public posters/banners). An open-ended question was asked to explore how respondents determined accuracy of information. Statistical analysis was conducted using STATA 15.0 software (StataCorp Texas) with significance placed at P<.05. Approval to conduct this study was obtained from the Lagos State University Teaching Hospital Health Research Ethics Committee.

RESULTS

A total of 719 respondents completed the survey. Most respondents (n=642, 89.3%) obtained COVID-19–related information from the internet. The majority (n=617, 85.8%) considered their source(s) of information to be accurate, and 32.6% (n=234) depended on only 1 out of the 7 potential sources of COVID-19 information. Respondents earning a monthly income between NGN 70,000-120,000 had lower odds of obtaining COVID-19 information from the internet compared to respondents earning less than NGN 20,000 (odds ratio [OR] 0.49, 95% CI 0.24-0.98). In addition, a significant proportion of respondents sought accurate information from recognized health organizations, such as the Nigeria Centre for Disease Control and the World Health Organization.

CONCLUSIONS

The internet was the most common source of COVID-19 information, and the population sampled had a relatively high level of perceived accuracy for the COVID-19 information received. Effective communication requires dissemination of information via credible communication channels, as identified from this study. This can be potentially beneficial for risk communication to control the pandemic.
CoV-Seq, a New Tool for SARS-CoV-2 Genome Analysis and Visualization: Development and Usability Study (Preprint)
Authors: Liu Boxiang , Liu Kaibo , Zhang He , Zhang Liang , Bian Yuchen , Huang Liang
Published: July 2020

BACKGROUND

COVID-19 became a global pandemic not long after its identification in late 2019. The genomes of SARS-CoV-2 are being rapidly sequenced and shared on public repositories. To keep up with these updates, scientists need to frequently refresh and reclean data sets, which is an ad hoc and labor-intensive process. Further, scientists with limited bioinformatics or programming knowledge may find it difficult to analyze SARS-CoV-2 genomes.

OBJECTIVE

To address these challenges, we developed CoV-Seq, an integrated web server that enables simple and rapid analysis of SARS-CoV-2 genomes.

METHODS

CoV-Seq is implemented in Python and JavaScript. The web server and source code URLs are provided in this article.

RESULTS

Given a new sequence, CoV-Seq automatically predicts gene boundaries and identifies genetic variants, which are displayed in an interactive genome visualizer and are downloadable for further analysis. A command-line interface is available for high-throughput processing. In addition, we aggregated all publicly available SARS-CoV-2 sequences from the Global Initiative on Sharing Avian Influenza Data (GISAID), National Center for Biotechnology Information (NCBI), European Nucleotide Archive (ENA), and China National GeneBank (CNGB), and extracted genetic variants from these sequences for download and downstream analysis. The CoV-Seq database is updated weekly.

CONCLUSIONS

We have developed CoV-Seq, an integrated web service for fast and easy analysis of custom SARS-CoV-2 sequences. The web server provides an interactive module for the analysis of custom sequences and a weekly updated database of genetic variants of all publicly accessible SARS-CoV-2 sequences. We believe CoV-Seq will help improve our understanding of the genetic underpinnings of COVID-19.
Avaliação da imagem dos ápices de primeiros pré-molares superiores em radiografias dissociadas
Authors: Furlan Santos Antonio , Elisa da Silva Ana , Leites Larentis Naiara , Fontanella Vania
Published: July 2020

A dissociação radiográfica de raízes e condutos, amplamente utilizada em odontologia, resulta em imagens com graus variáveis de distorção. Com o objetivo de avaliar se a perda de nitidez associada à distorção compromete a identificação de ápices dentários, foram analisados 100 pares de radiografias de primeiros pré-molares superiores (orto e mesiorradial). Três observadores calibrados avaliaram, em condições ideais de interpretação, as raízes vestibular e palatina de cada dente na imagem dissociada, quanto à identificação de cada ápice, atribuindo-lhes escores de 0 a 4 (0 = não; 1= mal; 2 = razoavelmente; 3= bem; 4= muito bem identificado). Observou-se que a raiz palatina apresentou escores mais altos e que a vestibular apresentou escores mais baixos (teste de Wilcoxon, p =0.01). Conclui-se que a dissociação radiográfica de primeiro pré-molar superior compromete a nitidez da imagem do ápice da raiz vestibular.
Analysis of Factors Affecting Earnings Management Moderated by Institutional Ownership
Authors: Wirianata Henny
Published: July 2020

The objective of this research is to examine the empirical evidence of leverage, profitability, growth, and institutional ownership on earnings management in manufacturing companies listed in Indonesia Stock Exchange. This research used 54 listed manufacturing companies in Indonesia Stock Exchange, selected using a purposive sampling method, during the research period 2016 until 2018. Data were analyzed using multiple regression analysis. The result of the research indicates that leverage proxied by DAR has a negative significant influence on earnings management. Size and growth have a positive significant influence on earnings management. Profitability proxied by ROA and institutional ownership has no significant influence on earnings management. The results also show that institutional ownership could moderate but not significant the influence of leverage, profitability, and growth towards earnings management of manufacturing companies listed in Indonesia Stock Exchange period 2016-2018.
Mitigasi Spritual dalam Naskah Lontar Roga Sanghara Bhumi
Authors: Ardiyasa I Nyoman Suka
Published: July 2020

The island of Bali is an island very vulnerable to disaster, it is proven with historical records that Bali has experienced a major earthquake better known as Gejer Bali. Various efforts have been made by the community from the past until now in the effort of mitigation done in sekala and niskala.   In the community, people believe that if they want to avoid the disaster then the community must implement the tri hita karana, while niskala (theologically) done with various upakara. Upakara sources and the types of disasters that occur in this world are believed to be contained in the Lontar Roga Sanghara Bhumi manuscript. But the existence of the manuscript is not much to know so it is necessary to conduct a more in-depth review so that it can be disseminated to the public. To focus on these reviews, we focused on three problem formulas: analyzing the summary of the Roga Sanghara Bhumi lontar manuscripts, the types of disasters mentioned in the Roga Sanghara Bhumi lontar, 
and the theological attempts made in dealing with the disasters mentioned in lontar Roga Sanghara Bhumi.
From the results of the study conducted it is briefly known that the lontar Roga Sanghara Bhumi contains about the causes of catastrophe or disaster occurred in the world, the types of catastrophes or disasters that can occur in the world and some characteristics of the coming disaster or disaster, while the types The disaster mentioned in the lontar of Roga Sanghara Bhumi is a type of disaster that repeats every sasih it and the kind of disaster that occurs which is seen from the bad gesture, in the concept of Lontar Roga Sanghara Bhumi called Durmanggala. The theological efforts undertaken in tackling the disasters mentioned in the lontar of Roga Sanghara Bhumi are performing ceremonies that are shown to Ida Sang Hyang Widhi Wasa with the aim of pleading for salvation such as Prayascita Ceremony, Master Piduka, Labuh Gentuh, Jagat, Pamahayu Bumi and Nangluk Mrana. All these ceremonies are theological (mitigation) efforts in reducing disaster risks that occur on earth.
Prinsip Hidup Kawruh Begja dalam Perspektif Anton Bakker
Authors: Marsono Marsono
Published: July 2020

This article outline aims to understand the principle of life in this kind of Javanese society based on Anton Bakker’s metaphysical theory. Describes the position of the Javanese as being there among other creators in a structure of reality. Javanese people in this context are assumed to have metaphysics, namely placing themselves as subjects as well as objects of metaphysics, and occupying a position as a being for themselves as well as being for others. The principle of kawruh thus is more dominant showing mental aspects in the form of the soul but, it is emphasized again that the soul and the body remain a unity of reality inseparable with their respective roles. The Javanese do not merely look at reality through their own perspective, but also look at the physical reality of the world outside themselves, then see the range of connectedness between themselves and the reality outside themselves.
Vibrasi Pikiran, Kerusakan Ozon dan Bencana Alam Satu Kesatuan Sistem Kesadaran Kosmos Perspektif Teo-Kosmologis Post Metafisika
Authors: Donder I Ketut
Published: July 2020

The Vedas have various concepts and theories about the creation of the universe. Vedic concepts are accepted by revelation, while Vedanta theories are created through contemplative research on macrocosms and microcosms. Creation theories in Vedanta, are: Manah theory or the theory of Virat, this theory states that the universe created from the mind of God. The second is the theory of Sabda, this theory states that the universe is created from the Voice of God, this theory is similar to the Big Bang theory. Other theory is the theory of Apah, this theory states that the universe came from water, and there are also many other theories. These theories seem to be compatible with modern scientific theories. This shows that the Vedic teachings have been an inspiration for scientists.
The Manah theory, sabda theory, Apah theory, and other theories are embedded by Hiranyagarbha theory. This theory states that the human mind, the mind of the cosmos, and the human mind, historically-theo-cosmologically, have a very close relationship. Hiranyagarbha theory that became the foundation of Hindu Cosmology describes that before the universe was created, there was an element of astaprakriti, the eight subtle elements without size (tan matra). The eight supernatural elements are buddhi (intellect), manas (mind), ahamkara (ego), akhasa (ether), vayu (air), teja (fire), apah (water), and pritivi (land), all within the warehouse. The universe is called Hiranyagarbha. Based on the Hiranyagarbha theory, the creation of the macrocosm begins with the consciousness of God, then moves the mind of God (Manas) connected to the manas that is on Hiranyagarbha. After the macrocosm, humans were created, then the mind of God, the mind of the cosmos, and the human mind have connectivity with each other. Therefore, do not ever think negative about anything.
KEBIJAKAN FORMULASI JUDI ONLINE DALAM HUKUM INDONESIA
Authors: Bunga Dewi
Published: July 2020

Various electronic devices equipped with internet networks have opened up opportunities for emerging crimes in cyberspace. Online gambling is a form of traditional crime transformation that turns into a crime operating in cyberspace. In the formulation of legal policies in various countries, not all countries declare online gambling as a criminal act. There are countries that legalize online gambling, there are countries that are in the gray area, and some are banning
online gambling. In this study there are two issues discussed, namely the application of jurisdiction in the criminal acts of online gambling and criminal law policies against online gambling. The application of jurisdiction in criminal acts of online gambling must pay attention to the rules of international law, where a country cannot enforce its rule of law in another country. Provisions regarding online gambling jurisdiction are regulated in Article 2 of Act Number 11 of 2008
concerning Electronic Information and Transactions. International cooperation in law enforcement on online gambling can be carried out as long as there are international agreements between countries and both countries alike establish online gambling as a crime. Criminal law policy on online gambling in Indonesia formulates online gambling as a criminal act as stipulated in Article 27 paragraph (2) of Act Number 11 of 2008 concerning Information and Electronic Transactions.
Upacara Sapuh Leger Sebagai Aplikasi Ajaran Manusa Yadnya di Lingkungan Padang Griya Kelurahan Padangsambian Denpasar Barat
Authors: Ratih Ida Ayu , Dharma Putra Anggara Putu , Laksana Utama Putu Kussa
Published: July 2020

In Hindu, someone who is born to coincide with wuku wayang is a child who falls into the category of "cemer", because it has the same birthday as Bhatara Kala. Bhatara Kala will eat every child who has the same birth day as him, so to avoid the pursuit of Bhatara Kala every child is required to carry out the Sapuh Leger Ceremony. This study aims to address several issues including: (1) The procession of the Sapuh Leger Ceremony, (2) Application of the teachings of Manusa Yadnya, (3) the meaning of symbols in the Sapuh Leger Ceremony in the Padang Griya Environment, Padangsambian Village, West Depasar.

This type of research is qualitative, with the determination of informants using the purposive sampling method. As well as collecting data using non-participant observation, structured interviews with recording techniques, recording and shooting, and literature study methods. Data analysis conducted in this study used a descriptive qualitative method.

The results of the study showed that the procession of the Sapuh Leger Ceremony in the Padang Griya Environment Padangsambian Village, West Denpasar was carried out from morning to noon, starting from offering offerings to Ida Sang Hyang Widhi as a manifestation of Oton God, licking to cleanse themselves in beji and in the Lord Shiva Buddhist temple. The application of the teachings of Manusa Yadnya in the Sapuh Leger Ceremony lies in the procession of the implementation of the Natab Banten Oton procession. Meaning of symbols in the Sapuh Leger Ceremony is found in the Facilities used in the ceremony and staging of the Sapuh Leger Puppet. So that through each symbol used in the ceremony to form a communication to deliver a message so that children born in wuku wayang always find prosperity in their lives.
Development and Application of High-Precision Algorithm for Non-Target Identification of Organohalogens Based on Ultrahigh-Resolution Mass Spectrometry
Authors: Fu Qing-Long , Fujii Manabu , Kwon Eunsang
Published: July 2020

The brominated and/or chlorinated organic compounds (referred to as organohalogens) are frequently detected in natural and engineered environments. However, the ultrahigh resolution mass spectrometry (UHR-MS)-based non-target identification of the organohalogens remains challenging due to the presence of vast number of halogenated and non-halogenated organic molecules in the same aqueous sample. In this study, a new algorithm, namely NOMDBP Code, was developed, based on natural organic matter (NOM) chemistry, to simultaneously identify organohalogens and non-organohalogens from the UHR-MS spectra of natural and engineered waters. In addition to isotopic pattern extraction, for the first time, three optional filter rules (namely selection of minimum non oxygen heteroatoms, inspection of newly formed halogenated disinfection byproducts [X23 DBPs] and precursors) were incorporated in our code, which can accurately identify DBPs associated peaks and further elucidate the X-DBPs generation and transformation mechanisms. The formulae assignment rate against previously reported 2,815 unique organohalogens and their 11,583 isotopologues was determined to be >97%. Application of our algorithm to disinfected NOM indicated that oxygen-containing X-DBPs species accounted for a majority of X-DBPs. Further, brominated X-DBPs (Br-DBPs) during disinfection process were characterized by higher degree of unsaturation compared to chlorinated X-DBPs (Cl-DBPs). Our algorithm also suggested that, in addition to electrophilic substitution and electrophilic addition reactions, the decomposition/transformation is another important mechanism in Br-DBPs formation. Results of this study highlight the superior potential of this code to efficiently detect yet- unknown organohalogens (including organohalogens with non-oxygen heteroatoms) in a non-target manner and identify their generation mechanism during the disinfection process
A study of correlation between thyroid disorders and menstrual disorders in reproductive age group
Authors: Moulika Shirish Shah  , Patange R. P
Published: July 2020

Present study to evaluate and detect thyroid dysfunction and its correlation in patients with a menstrual disorder in the reproductive age group. Research objectives are to study the prevalence of thyroid disorders in relation to menstrual disorders and study the correlation between menstrual irregularities and thyroid dysfunction. Precise assessments of thyroid hormones in serum become achievable easily and accurately with the introduction of new hormographical research techniques. Hypothyroidism diagnosis is advantageous because it typically relieves the patient of all symptoms. Therefore, the assessment of thyroid activity forms an essential component for the evaluation of a female with menorrhagia or otherwise menstrual irregularities. The individuals are rescued from repeated curettage from hysterectomy by early diagnosis of hypothyroidism Objectively measured menstrual blood losses were 35 ml per menstrual cycle (patients in the age group exposures.