bluuebunny/crossref_metadata_2025 huggingface dataset:
Optical coherence tomography and microperimetry in the early diagnosis of glaucoma
Authors: Plyaskina U. S. , Biryukov V. V. , Frolov M. A.
Published: September 2022

The review presents modern possibilities of early diagnosis of glaucoma using optical coherence tomography (OCT), angio-OCT and microperimetry. We analyzed literature data for the last decade, focused on testing patients with suspected glaucoma or diagnosed with glaucoma, including its various stages. The data confirm the advantages of OCT, angio-OCT anf microperimetry, such as fast testing procedures, non-invasiveness, high informativeness, sensitivity and specificity of the methods, as well as real possibilities of early detection of glaucoma, which are especially promising if a combination of methods is used.
Religious Dynamics in Mass Media: A Study on Popular Articles in Kompas and Republika Newspapers
Authors: Khusairi Abdullah , Fata Ahmad Khoirul
Published: September 2022

This paper examines the religious dynamics image in contemporary Indonesia was presented by the printed mass media. Using van Dijk's critical discourse analysis method, and the hierarchy of influence media content of Pamela Shoemaker and Stephen Reese, this paper examines the content of popular articles in the Kompas and Republika for the period 2013-2017. These two print media were chosen because they are two different ideological poles. Kompas was born from Catholic activists and supported by several military officers. Meanwhile, Republika was founded by Islamic activists with government support. The themes of popular articles in both media revolve around issues of the state and democracy, political dynamics and Islamic parties, and spirituality. The religious discourse contest at Kompas and Republika was filled with Muslim scholars and leaders of Islamic mass organizations. Kompas does not provide enough space for new writers so that its popular articles are filled by monotonous scholars. On the other hand, Republika has promoted many new writers. However, Republika also features internal writers. Popular articles from Kompas and Republika put forward a moderate religious face. However, Republika seems to emphasize the Islamic side more, while Kompas appears to be more inclusive.
A Study on the Protection of Fundamental Right of Undocumented Immigrant Children: Focused on the European Countries
Authors:   European Constitutional Law Association, Kim Na Roo
Published: September 2022

About 20,000 undocumented immigrant children live in Korea, but the fundamental rights for their lives are not guaranteed. In particular, they are suffering from problems such as birth registration, the infringement of the right to health and education. With regard to the birth registration of undocumented immigrant children, european countries stipulate that the birth of all children in that country can be registered regardless of their parents’ status and automatically issue birth certificates without further action. Since the universal birth registration system and issuance of related documents are the basic premise for respecting children's dignity as human beings, Korea also needs to introduce such procedures as soon as possible. Regarding the right to health of undocumented immigrant children, providing daily medical services other than emergency medical services is considered a social security area, but children's health is the most significant element for life maintenance and whole-person development, so medical access should be guaranteed regardless of the legality of residence status. We need to guarantee minimum medical access of undocumented children to maintain their health through providing emergency medical services, primary and secondary medical care services to the same extent as Korean children, or providing cost support. And in respect of guaranteeing undocumented immigrant children's right to education, we should strive to ensure that undocumented immigrant children receive education without discrimination in accordance with international society’s good practice of explicitly stipulating all children's right to education including undocumented immigrant children.
The Contact Point and Difference between the Principle of Prohibition of Excessively Abundant Restriction and the Principle of Prohibition of Excessively Deficient Protection as Constitutional Principles
Authors:   European Constitutional Law Association, YI ZOONIL
Published: September 2022

The proportionality principle is a constitutional principle that has a constitutional basis and effect. It is generally agreed that the principle of proportionality consists of four partial principles: the principle of justification for the end, the principle of suitability of means, the principle of minimal harm, and the principle of balance of legal interests. The principle of proportionality is embodied in the principle of prohibition of excessively abundant restriction and the principle of excessively deficient protection in accordance with legal interests guaranteed by constitutional rights. In the case of the defensive right that can demand negative actions from the state, the proportionality principle is embodied as the principle of prohibition of excessively abundant restriction, and in the case of the benefit right that can demand positive actions from the state, the proportionality principle is embodied as the principle of prohibition of excessively deficient protection. Since the principle of proportionality is specified in common between the principle of prohibition of excessively abundant restriction and the principle of prohibition of excessively deficient protection, the four partial principles of the principle of proportionality must be applied whether they are applied as the former principle or the latter. However, the specific contents of the application of the four partial principles included in the proportionality principle may vary because the protected legal interests and restrictions that are problematic in the principle of prohibition of excessively abundant restriction and the principle of prohibition of excessively deficient protection are different.
Antagonistic activity of synbiotics: Response surface modeling of various factors
Authors: Evdokimova Svetlana , Karetkin Boris , Zhurikov Mikhail , Guseva Elena , Khabibulina Natalia , Shakir Irina , Panfilov Victor
Published: September 2022

Synbiotic compositions have a great potential for curing microbial intestinal infections. Novel targeted synbiotics are a promising field of the modern functional food industry. The present research assessed the effect of various fructan fractions, initial probiotic counts, and test strains on the antagonistic properties of synbiotics.

The research involved powdered roots of Arctium lappa L. and strains of Bifidobacterium bifidum, Bacillus cereus, and Salmonella enterica. The experiment was based on the central composite rotatable design. A water extract of A. lappa roots was purified and concentrated. Fructan fractions were precipitated at various concentrations of ethanol, dried, and sub jected to carbon-13 nuclear magnetic resonance (13C-NMR) spectrometry. The bifidobacteria and the test strains were co-cultivated in the same medium that contained one of the fractions. Co-cultivation lasted during 10 h under the same conditions. The acid concentrations were determined by high-performance liquid chromatography to define the synbiotic factor.

The obtained fructans were closer to commercial oligofructose in terms of the number and location of NMR peaks. However, they were between oligofructose and inulin in terms of signal intensity. The response surface analysis for bacilli showed that the minimal synbiotic factor value corresponded to the initial probiotic count of 7.69 log(CFU/mL) and the fructan fraction precipitated by 20% ethanol. The metabolites produced by the bacilli also affected their growth. The synbiotic factor response surface for the experiments with Salmonella transformed from parabolic to saddle shape as the initial test strain count increased. The minimal synbiotic factor value corresponded to the lowest precipitant concentration and the highest probiotic count.

The research established a quantitative relationship between the fractional composition of fructans and the antagonistic activity of the synbiotic composition with bifidobacteria. It also revealed how the ratio of probiotic and pathogen counts affects the antagonism. The proposed approach can be extrapolated on other prebiotics and microbial strains in vivo.
The concept of eudaimonia in the context of Aristotelian rational theology
Authors:   Immanuel Kant Baltic Federal University, Svetlov Roman V.
Published: September 2022

The Aristotelian doctrine of the knowledge of God offers two models of this process: by nature and by learning. A careful reading of Nicomachean Ethics allows us to consider this text as an important source for the Stagirite’s teaching on the knowledge of God “by nature”. Eudaimonia in Aristotle’s interpretation means life according to nature. But in human nature the mind is dominant. Therefore, mental activity is the highest and happiest and filled with the highest pleasure. This is precisely the basis for the superiority of theoretical life over the practical. Of course, immortality is unattainable for a person. Man is not only a rational being, but also a social and bodily one. In its highest manifestation, in the act of thinking, he is incorporeal. Intellectual contemplation, which allows one to grasp an object in its being, to see its form, is a way of being outside the body. The kind of being that God undoubtedly possesses. Eudaimonia, contemplation and the most correct, highest pleasure coincide in it. That is, the highest form of a happy life that is available to a person is not just divine happiness, but the very happiness of a deity. The person who has comprehended it will no longer know God through reflection and reason, but directly, through his own experience.
Features of the ecclesiological discourse of St Porphyry Kavsokalivit
Authors:   Russian Christian Academy for the Humanities, Vashchenko Priest Andrey
Published: September 2022

The paper analyzes the approach of St Porphyry Kavsokalivit to ecclesiological issues, in particular his central statement, “The Church is eternal and uncreated”. An attempt to determine the origins and logical justification of this concept is made. The emergence of St Porphyry’s unusual theological formula relates to the literal interpretation of the New Testament metaphor of the Church as the Body of Christ (Eph 1:23, 1 Cor 12). A specific feature of St Porphyry’s ecclesiological discourse is the affirmation of sameness of the Church and Christ, the Church and God, the Church and the Holy Trinity. The relationship of his theological ideas with the ecclesiological constructions of some Christian writers (St Epiphanius of Cyprus) is also shown. Along with the original approach from a theological point of view, St Porphyry Kavsokalivit is quite traditional when he talks about the Church in practical terms, about its significance for salvation and the canonical structure of Christianity. The St Porphyry’s idea of Church is more mystical than theological. His thought is based not on rationalization, but on a subjective experience of the “churchness”. Given the dogmatic uncertainty in ecclesiology in the Orthodox Church, the contradictory and unusual concept of the eternal and uncreated Church of St Porphyry can be qualified as a private theological opinion.
Neuronal Nicotinic Acetylcholine Receptor Agonists
Authors: McDonald Ian A. , Vernier Jean-Michel , Cosford Nicholas , Corey-Naeve Janis
Published: September 2022

In contrast to the considerable effort over many years to design agonists of the muscanmc acetylcholine receptor, until recently little attention has been directed towards agonists of the nicotinic family of acetylcholine receptors (NAChRs). Nevertheless, the structure and function of NAChRs has been a topic of intense research for several decades. Currently available NAChR agonists were discovered either as natural products or have been the result of limited structure-activity relationship studies based on natural products. These agonists were initially identified in classical ligand binding assays and characterized by various in vitro and in vivo models using rodents or rodent tissue preparations. Recent advances in the molecular biology of NAChRs have allowed the generation of stable cell lines expressing recombinant human NAChRs. The incorporation of the .e cell lines into high throughput functional screening assays has stimulated the search for novel, subtype selective NAChR agonists which should have therapeutic utility for the treatment of a number ofCNS disorders, such as Alzheimer's disease, Parkinson's disease, attention deficit disorder and schizophrenia. Some of these agents, for example SIB-1508Y, ABT-418 and DMXB (GTS 21), are presently helping to establish the clinical utility of nicotinic agonists in these diseases. This review focuses on the molecular biology of NAChRs, the development of cell-based functional assays, and the use of these assays to critically support structure-activity relationship studies of two series of compounds from our own laboratories.
5-Hydroxytryptamine (5-HT)3 Receptors: Molecular Biology, Pharmacology and Therapeutic Importance
Authors: Eglen R.M. , Bonhaus D.W.
Published: September 2022

The 5-HT3 receptor is unique among known monoamine receptors in that, rather than being a G­ protein-coupled receptor, it forms a ligand-gated ion channel. In the CNS, this receptor is found in high density in· nuclei of the lower brainstem, area postrema and nucleus of the tractus solitarius. Lower densities of the receptor are found in the cerebral cortex and limbic areas, including the hippocampus. In the periphery, 5-HT3 receptors are located on pre- and postganglionic neurons of both sensory and enteric nervous systems. The receptor is a pentameric protein with multiple agonist and allosteric ligand binding sites. Thus it has structural and functional similarities with nicotinic, GABAergic and, other ligand gated ion channels.

5-HT3 receptor antagonists have been shown to produce beneficial effects in animal models of cognitive and psychiatric disorders. Whether 5-HT3 receptor antagonists may have similar profound effects in the treatment of anxiety, depression or psychosis will be determined by the outcome of ongoing clinical trials. However, it is in the treatment of cancer chemotherapy induced emesis that 5-HT3 receptor antagonists have had their·greatest impact. The cytotoxic agents used in cancer chemotherapy provoke the release of 5-HT from enterochromaffin cells in the gastrointestinal tract. This 5-HT acts on 5-HT3 receptors in the central nervous system or on peripheral vagal afferent fibers to initiate vomit reflexes. 5-HT3 receptor antagonists block this action and thereby greatly reduce the number of emetic episodes that occur during cancer chemotherapy. The marked clinical efficacy of 5-HT3 receptor antagonists such as ondansetron, granisetron and tropisetron together with their lack of adverse side effects has revolutionized the treatment of cancer chemotherapy induced emesis.
Voltage-gated Na+ Channels as Targets for Anticonvulsant, Analgesic and Neuroprotective Drugs
Authors: Taylor C.P.
Published: September 2022

Voltage-dependent Na+ channels have been recognized for many years as targets for local anesthetic and antiarrhythmic drugs. In the past ten years, Na+ channels have increasingly been recognized as a target for anticonvulsant drugs (e.g. phenytoin, carbamazepine, lamotrigine). This same class of drugs has been used to treat neuropathic pain such as from trigeminal neuralgia, diabetic neuropathy or other nerve damage. More recently, it has become clear from results in vitro and with animal models that Na+ channel modulators similar to anticonvulsants have neuroprotective actions against ischemia, trauma and neurodegenerative diseases. This bri f review covers recent advances in the molecular biology of mammalian Na+ channels and the evidence that Na+ channel blockade with both conventional drugs and recently synthesized compounds may be useful for treatment of a variety of CNS diseases.
Is this the end of the road for bio-inspired road construction materials?
Authors: Tabakovic Amir
Published: September 2022

The global road network spans 64.3million km and is of huge significance for the social and economic development. The level of investment in road construction and maintenance is high, e.g. EU €44billion/year (2019), China €614.7billion/year (2019) and US €94billion/year (2019). Despite the level of investment, there has been minimal investment in the development of new asphalt technologies, particularly when compared with R&D investment in other industries, such as the automotive industry.
Despite the limited investment, there have been some innovations in asphalt technology. For the past 20 years, researchers have developed bio-inspired asphalt technology, self-healing and bio-binders and have applied them to asphalt pavements. This research has emerged as a response to global warming and the need to reduce both carbon emissions and reliance on oil in asphalt technology.
This paper charts the development of two bio-inspired technologies and considers their significance in relation to the need to reduce carbon emissions and oil dependence (in line with the UN strategic goals, specifically: SDG 9, 11 and 12). This paper considers the potential benefits of bio-inspired technologies and outlines the current barriers to their further development. This paper aims to begin a conversation with stakeholders on how to speed up the acceptance of bio-inspired asphalt technologies and their adoption in road design, construction and maintenance. Or is it the case that we have reached the end of the road for bio-inspired road construction materials?
Physical exercise as cytokine modulator in inflammatory immune response: a systematic review
Authors: Pertiwi Kartika Ratna , Yulianti Evy , Rustiasari Ukhti Jamil
Published: September 2022

Physical exercise contributes to maintain our health, through its role in inflammatory immune response. Cytokines are proteins that mediate communication between immune cells, either as pro- or anti-inflammation agents. Nonetheless, the dominance of pro- over anti-inflammatory cytokines during a workout, is harmful to health. This systematic review aimed at determining the effect of physical activity in modulating pro- and anti-inflammatory cytokines during immune response. Following Preferred Reporting Items for Systematic Reviews (PRISMA) guideline, literature searching was conducted in 3 databases which were PUBMED/MEDLINE, DOAJ and GARUDA, using keywords, citation tracking and snowballing. Inclusion and exclusion criterias were used to screen, while the Newcastle Ottawa Scale (NOS) was used to assess the quality of the articles. Data extraction and analysis were conducted descriptively. There were 376 articles identified, of which 329 were sorted and 82 were retrieved. Thirty articles underwent quality assessment, resulting to 12 inclusion studies. In conclusion, physical exercise influences the modulation of cytokine, whereby IL-6 and TNF-α (pro-) which increase at the beginning of exercise, are balanced by the increase of IL-10 (anti-inflammatory), which appears later in exercise or during recovery. For this purpose, physical exercise is recommended as a combination of aerobic and resistance exercise performed regularly at moderate intensity.
Определение глубин полимеризации бессвинцовых пьезокерамических паст для УФ 3D печати
Authors: Тихонов А. , Чугунов С. , Шишковский И.
Published: September 2022

In present study, the polymerization depths for the implementation of the laser stereolithography process in the system (oligomer - piezoceramics) on the wavelengths of 445–465 nm UV range were determined in the original BTO, KNN and NBT lead-free piezoceramic pastes. It was shown that powder pastes, which provide a polymerization depth more than 150 µm, are promising for using in 3D printing. Such depth was chosen to guarantee a sufficient overlap of neighboring layers during polymerization, at the laser beam velocity speed from 1 m/s and the distance between the laser paths of 50 µm. For NBT pastes, successful photo polymerization was carried out for the first time, and for KNN paste the process performance was significantly increased.
Влияние термической пост-обработки на спектральные сдвиги фотополимерных отражательных голограмм и её использование для получения цветоделённых изображений
Authors: Шелковников В.В. , Деревянко Д.И. , Пен Е.Ф.
Published: September 2022

The effect of post heat-treatment on the spectral properties of photopolymer reflection holograms scheme has been studied. It has been established that holograms with protective film retain a high diffraction efficiency of ∼ 90% and do not have additional shrinkage during heat treatment for several days at a temperature of 80–90°C. The holograms without a protective film, removed after exposition, when heated in the temperature range of 40–110°C, show effective shrinkage up to 17% without compromising diffraction efficiency. Addiction the degree of shrinkage from the time of keeping the hologram at a given temperature is described by the function biexponential growth with saturation. The parameters of the approximating function are calculated. The characteristic shrinkage times in the temperature range of 40–110°C decrease from hours to minutes for fast components and from tens of days to tens of minutes for the slow component. Effect large shift of spectral response was used to create color-separated holograms. Color-separated holograms were obtained in two ways: two-layer version with shrinkage of one of the layers, single-layer version using photoresistive pattern and subsequent shrinkage.
Сенсибилизация ионов европия (Eu-=SUP=-3+-=/SUP=-) тербием (Tb-=SUP=-3+-=/SUP=-) в керамике на основе кубического диоксида циркония, стабилизированного иттрием
Authors: Шакирова А.А. , Гусев Г.А. , Дементьева Е.В. , Аверин А.А. , Попова Т.Б. , Заморянская М.В.
Published: September 2022

In this work, stabilized f-ZrO2 ceramic samples with the compositions of (Zr0.82Y0.09Eu0.09)O1.91), (Zr0.82Y0.09Tb0.09)O1.91) and (Zr0.82Y0.09Eu0.045Tb0.045)O1.91 were studied.
The elemental composition was studied by electron probe microanalysis, and the luminescent properties were studied by local cathodoluminescence (CL). An analysis of the Eu3+ CL spectra confirmed the stabilization of the cubic phase in ceramics at room temperature. The study of the obtained CL spectra, the 5D4-7F5 Tb3+ band luminescence decay kinetics, CL images and excitation spectra showed europium sensitization by terbium in (Zr0.82Y0.09Eu0.045Tb0.045)O1.91.
Формирование контрастных изображений заданных объектов акустооптическим гиперспектрометром путем выборочной спектральной регистрации
Authors: Шипко В.В. , Самойлин Е.А. , Пожар В.Э. , Мачихин А.С.
Published: September 2022

The method of selecting the most informative spectral channels when using an acousto-optic hyperspectrometer in the mode of selective spectral registration is presented. The developed technique makes it possible to select spectral channels in which the maximum contrast of objects is observed against a certain background, provided that their spectral properties are known. The results of experimental studies of the technique confirm an increase in contrast compared with panchromatic and hyperspectral shooting modes in the entire optical range. The choice of spectral channels according to the presented technique can also be used both for the formation of transmission functions in a multi-window acousto-optic hyperspectrometer, and for the rapid formation of their high-contrast color-synthesized images.
Newborn Screening in Gaucher Disease: A Bright and Complicated Future
Authors: Ryan Emory , Jong Tiffany , Sidransky Ellen
Published: September 2022

Gaucher disease (GD) is one of the most common lysosomal storage disorders resulting from biallelic mutations in the GBA1 gene, causing a dysfunction of the lysosomal hydrolase, glucocerebrosidase (acid-β-glucosidase; E.C 3.2.1.45). Clinical manifestations are heterogenous and can include splenomegaly, anemia, and neurological impairments in the case of neuronopathic Gaucher disease types 2 and 3. Newborn screening, arguably the most important public health initiative to date, has been regularly conducted on newborns in the United States since the 1960s. The development of new low-cost screening methods and effective treatments are motivating the inclusion of GD and other lysosomal storage disorders in population-wide newborn screens. In this article, we review the history of newborn screening for GD, the screening methods used, and ethical considerations and challenges regarding the successful implementation of population-based newborn screening for GD.
Digital Storytelling Methods to Empower Young Black Adults in COVID-19 Vaccination Decision-Making: Feasibility Study and Demonstration
Authors: Maragh-Bass Allysha , Comello Maria Leonora , Tolley Elizabeth Ellen , Stevens Jr Darrell , Wilson Jade , Toval Christina , Budhwani Henna , Hightow-Weidman Lisa
Published: September 2022

Background

Despite high rates of novel COVID-19, acceptance of COVID-19 vaccination is low among Black adults. In response, we developed a digital health intervention (Tough Talks-COVID) that includes digital stories created in a workshop we held with young Black adults.

Objective

Our formative research using digital storytelling workshops asked 3 research questions: (1) What issues did participants have in conceptualizing their stories, and what themes emerged from the stories they created? (2) What issues did participants have related to production techniques, and which techniques were utilized in stories? and (3) Overall, how did participants evaluate their workshop experience?

Methods

Participants were workshop-eligible if they were vaccine-accepting based on a baseline survey fielded in late 2021. Final participants (N=11) completed a consent process, all 3 workshops, and a media release form for their digital story. The first 2 workshops provided background information and hands-on digital storytelling skills from pre- to postproduction. The third workshop served as a screening and feedback session for participants’ final videos. Qualitative and quantitative feedback elements were incorporated into all 3 sessions.

Results

Digital stories addressed one or more of 4 broad themes: (1) COVID-19 vulnerability, (2) community connections, (3) addressing vaccine hesitancy, and (4) countering vaccine misinformation. Participants incorporated an array of technical approaches, including unique creative elements such as cartoon images and instant messaging tools to convey social interactions around COVID-19 decision-making. Most (9/11, 82%) strongly agreed the digital storytelling workshops were delivered as expected; 10 of 11 agreed (n=5) or strongly agreed (n=5) that they had some ideas about what story to tell by the end of the first workshop, and most (8/11, 73%) strongly agreed they had narrowed down their ideas by workshop two. Of the participants, 9 felt they would very likely (n=6) or likely (n=3) use digital storytelling techniques for personal use in the future, and even more were very likely (n=7) to use the techniques for professional use.

Conclusions

Our study is one of the first to incorporate digital storytelling as a central component to a digital health intervention and the only one to do so with exclusive focus on young Black adults. Our emphasis on digital storytelling was shown to be highly acceptable. Similar approaches, including careful consideration of the ethical challenges of community-based participatory approaches, are applicable to other populations experiencing both COVID-19 inequities and marginalization, such as other age demographics and people of color.
Dimensions of Interactive Pervasive Game Design: Systematic Review (Preprint)
Authors: Kai Liu , Tan Wee Hoe , Saari Erni Marlina
Published: September 2022

BACKGROUND

As the gaming industry grows around the world, playing pervasive games is becoming an important mode of entertainment. A pervasive game is one in which the game experience extends into the actual world or where the fictive world of the game merges with the physical world. How pervasive games can adapt to the ever-changing nature of technology and design in current society requires a comprehensive review.

OBJECTIVE

In this systematic review, we aimed to measure and analyze 4 dimensions of pervasive games through development, technology, experience, and evaluation. Moreover, we also aimed to discover and interpret their relationship with game, interaction, experience, and service design.

METHODS

We first chose 3 well-known databases, Web of Science, Scopus, and EBSCO, and searched from 2013 to April 2022. A strictly thorough Boolean search for research keywords such as “pervasive game,” “design,” and “interactive” resulted in 394 relevant articles. These articles were identified, screened, and checked for eligibility to find valid and useful articles, which were then categorized and analyzed using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) method.

RESULTS

The systematic selection was finally left with 40 valid and valuable articles. After categorization and analysis, all articles were classified according to 4 main themes, which were design and development (11/40, 28%), interaction and technology (15/40, 38%), users and experience (9/40, 23%), and evaluation and service (5/40, 13%). These 4 main areas can be subdivided into several smaller areas.

CONCLUSIONS

In the 4 areas of game design, interaction design, experience design, and service design, many scholars have studied pervasive games and made contributions. Although the development and technology of pervasive games have evolved with the times, there is still a need to strengthen emerging design concepts within pervasive games.
Bone Defect Animal Model for Hybrid Polymer Matrix Nano Composite as Bone Substitute Biomaterials
Authors: Kashan Jenan S. , Hamdan Wisam K. , Fakhri Baha
Published: September 2022

Addition of bioactive materials such as Titanium oxide (TiO2), and incorporation of bio inert ceramic such as alumina (Al2O3), into polyetheretherketone (PEEK) has been adopted as an effective approach to improve bone-implant interfaces. In this paper, hot pressing technique has been adopted as a production method. This technique gave a homogenous distribution of the additive materials in the proposed composite biomaterial. Different compositions and compounding temperatures have been applied to all samples. Mechanical properties and animal model have been studied in all different production conditions. The results of these new TiO2/Al2O3/PEEK biocomposites with different compositions were promising, mechanical properties within the range of human cortical bone, suitable for load bearing applications. At the same time, in vivo test shows no inflammation reaction with implanted samples. Sustained viability in contact with the sample over seven-day period, showed evidence of excellent biocompatibility in injured rejoins.
Fractional metric dimension of generalized prism graph
Authors: Goshi Nosheen , Zafar Sohail , Rashid Tabasam
Published: September 2022

Fractional metric dimension of connected graph G was introduced by Arumugam et al. in [Discrete Math. 312, (2012), 1584-1590] as a natural extension of metric dimension which have many applications in different areas of computer sciences for example optimization, intelligent systems, networking and robot navigation. In this paper fractional metric dimension of generalized prism graph Pm × Cn is computed using combinatorial criterion devised by Liu et al. in [Mathematics, 7(1), (2019), 100].
El derecho fundamental al desarrollo social libre de corrupción
Authors: Piña Libien Hiram Raúl , Uribe Arzate Enrique , Flores Martínez Alejandra
Published: September 2022

El presente trabajo tiene como propósito plantear la hipotética construcción del derecho fundamental al desarrollo social libre de corrupción, para constituirse como un intento de superación académica de las nociones de derecho al desarrollo, al desarrollo social, al desarrollo duradero, al desarrollo sostenible y al desarrollo sustentable, así como de la representación gráfica de la corrupción propuesta por Robert Klitgaard, mediante un esquema que propone integrar las funciones del Estado, las obligaciones de las autoridades en materia de derechos humanos, el derecho de acceso a la información pública, la rendición de cuentas y la coordinación entre las autoridades de los órdenes de gobierno competentes en la prevención, detección y sanción de responsabilidades administrativas y hechos de corrupción, así como en la fiscalización y control de recursos públicos, y las responsabilidades de los servidores públicos.
The Effect of Branch Managers' Transformational Leadership on Job Performance: Focusing on the Mediating Effect of Psychological Empowerment in the Financial Sector
Authors:   Korean Academy of Leadership, Jang MiKyung , Shim JiHyun
Published: September 2022

This study was conducted to investigate the effect of branch managers' transformational leadership on job performance and to understand the mediating effect of psychological empowerment in the financial sector. In order to achieve the purpose of the study, a survey was conducted on all employees except the branch manager working at N Bank, and the responses of 243 copies were used for analysis. For hypothesis verification, SPSS 21.0 and AMOS 23.0 were used to analyze factor analysis, correlation analysis, and estimate coefficients in structural equations. As a result of the analysis, it was found that the branch manager's transformational leadership had a positive (+) effect on job performance and psychological empowerment, and psychological empowerment mediated the relationship between transformational leadership and job performance. This study presented theoretical and practical implications in terms of how branch managers should demonstrate leadership for members in the financial sector, which is highly dependent on excellent human resources due to the nature of providing face-to-face services to customers.
Frecuencia de hiponatremia posoperatoria en pacientes sometidos a cirugía mayor en un centro de tercer nivel
Authors: Solis Jose Gabriel , Flores Padilla Guillermo , Paniagua Sierra José Ramón
Published: September 2022

Contexto: la hiponatremia posoperatoria es una complicación frecuente que se encuentra hasta en el 4?% de los pacientes sometidos a cirugía y que además es un factor independiente de mortalidad intrahospitalaria. Hasta ahora, los estudios se enfocan en las primeras horas posteriores a la cirugía, existiendo poca literatura que abarque hasta el periodo posoperatorio tardío.
Objetivo: evaluar la frecuencia y las características de hiponatremia en la primera semana posoperatoria.
Metodología: se incluyeron pacientes sometidos a cirugía mayor durante un periodo de 18 meses. Se determinó el nivel de sodio a las 24 horas, al tercer, quinto y séptimo día del procedimiento. Se clasificó de acuerdo con el tipo de cirugía realizada y se documentó la presencia de datos clínicos y desenlaces de los pacientes.
Resultados: 280 pacientes fueron estudiados, de los cuales 20 (7,1?%) desarrollaron hiponatremia durante el primer día posoperatorio, 34 (12,1?%) en el tercero, 30 (10,7?%) en el quinto día y 31 (11?%) en el séptimo día. En el primer día posoperatorio, los pacientes sometidos a cirugías urológicas y gastrointestinales desarrollaron hiponatremia con mayor frecuencia. Ninguno de los pacientes desarrolló complicaciones graves y no hubo relación entre la edad, el género o el tipo de soluciones y el desarrollo de hiponatremia.
Conclusiones: la hiponatremia es una complicación frecuente de varios tipos de procedimientos quirúrgicos que puede desarrollarse en los primeros siete días posoperatorios.
The Effect of Housing Market Consumer Index and Trends of Sales Price Index on the Auction Bid Price Ratio of Apartments
Authors:   Konkuk Research Institute of Real Estate and Urban Studies, Lim Jin-Young , Yoo Seon-Jong , Shin Bo-Yeon , Shin Eun-Jung
Published: September 2022

The housing market consumer index, the trends of sales price index and the auction bid price ratio are used as indicators to judge and the real estate market. Whereas there have been several studies that analyzed the relationship between the auction bid price ratio and the housing market consumer index, studies on the trends of sales price index are insufficient. This study examined the determinants of the auction bid price ratio in apartment auctions, and through empirical analysis with the housing market consumer index and the trends of sales price index, it tried to find out how the two indices affect the real estate auction market. The study set the time scope to 6 years between January, 2015 and December, 2020 and the space scope to Gangnam-gu, Seocho-gu, and Songpa-gu of Seoul. Independent variables were set as housing market, auction, local, location, article, and time of a successful bid. The analysis method used multiple linear regression analysis using a hedonic price model. As a result of analysis, it was found that the housing market consumer index and the trends of sales price index have a positive effect on the auction bid price ratio. Moreover, the failure in bidding, the land registration, the tenants with opposing power, and the lien have a negative effect on the auction bid price ratio, and the number of bidders has a positive effect on the auction bid price ratio. In addition, more than 30 years of elapsed years, small and medium sized space, and medium-large sized space have a positive effect on the auction bid price ratio, and the timepoint of 2018, 2019, and 2020 were found to have a positive effect on the auction bid price ratio. It is expected that auction bidders will be able to make rational decisions by judging and predicting the situation of the real estate market and auction market.
Podcasts sobre autismo
Authors: Vidica Ana Rita , Pavan Ricardo , Abreu Tiago
Published: September 2022

O Transtorno do Espectro do Autismo é uma categoria diagnóstica que, socialmente, se traduz na existência de uma comunidade formada por pessoas engajadas pelo tema e representação social de pessoas autistas. Com base nesta premissa, aproximamos os estudos críticos do autismo com os Estudos Culturais. A partir destas aproximações conceituais, propomos uma análise de capas de podcasts brasileiros sobre autismo presentes nas plataformas digitais a partir do modelo de análise cultural e as reflexões sobre como pensam as imagens, para observar as conjunturas envolvidas nos elementos das imagens, as questões políticas abordadas nos estudos críticos do autismo e suas representações midiáticas. Obtemos como resultados a percepção de que as capas de podcasts produzidos por autistas carregam diferenças culturais em relação àquelas produzidos por profissionais e especialistas em autismo.
Workplace democracy and employee productivity in construction firms
Authors: Odiwo Williams Omokhudu , Agol Nefisat Margaret , Egielewa Peter Eshioke , Ebhote Oseremen , Akhor Sadiq Oshoke , Ogbeide Frederick , Ozuomode Daniel Charles
Published: September 2022

The research looked at workplace democracy and employee productivity in a few construction enterprises in Edo State, Nigeria. The study’s population consisted of employees from four different construction enterprises in Edo State to meet the objectives. Yamane’s (1967) algorithm was used to generate a sample size of about 302 from the whole population, of which 261 were received but only 251 were legitimate, while 10 were rejected. A structured questionnaire that has undergone a reliability test was used to obtain the necessary information from the respondents. Descriptive statistics and regression analysis were used to assess the information gathered from the respondents. The study discovered that the ideal workplace democracy feature that existed among the workforce of chosen construction enterprises in Edo State was justice. It also revealed that the workplace democracy characteristics of participation-criticism, transparency, and equality are negatively associated with employee productivity. Still, the justice and accountability dimensions are positively related to employee productivity. Concerning these findings, the study suggests that firms ensure that management is committed, visible, and accessible to employees at all levels, establish a grievance system through which employees can make complaints in a protected manner, and implement effective training programs to improve workplace democracy
COMPARATIVE ANALYSIS OF THREE MACHINE LEARNING MODELS FOR EARLY PREDICTION OF SKELETAL CLASS-III MALOCCLUSION FROM PROFILE PHOTOS
Authors: AKSOY Selahattin , KILIÇ Banu , SÜZEK Tuğba
Published: September 2022

The pre-adolescent growth period is the best time for the skeletal Class-III malocclusion treatment. Diagnosis and treatment during this period continue to be a complex orthodontic problem. Class-III malocclusion is complicated to treat with braces frequently requiring surgical intervention after a pubertal growth spurt. In addition, delayed recognition of the problem will yield significant functional, aesthetic, and psychological concerns. This study presents the first fully automated machine learning method to accurately diagnose Class-III malocclusion applied across mobile images, to the best of our knowledge. For this purpose, we comparatively evaluated three machine learning approaches: a deep learning algorithm, a machine learning algorithm, and a rule-based algorithm. We collected a novel profile image data set for this analysis along with their formal diagnosis from 435 orthodontics patients. The most successful method among the three was the machine learning method, with an accuracy of %76.
Online sexual harassment among young female students in Ward 10, Baneshwor, Kathmandu, Nepal
Authors: Sharma Krishna , Shrestha Prabin , Shrestha Vijaya Laxmi , Shrestha Ram Bahadur
Published: September 2022

Background: Incidences of sexual harassment that occur over the internet
are growing with the development of new technologies and virtual
communities. This is a hidden form of sexual harassment that emerges
unpredictably and poses a public health challenge. The objective of this
study was to determine the extent of online sexual harassment
experienced by female students (aged 15–24 years) in Baneshwor (Ward
10), Kathmandu, Nepal. Methods: A total of 382 female students aged
15–24 – high school (10+2 level) to bachelor level – participated in
a quantitative cross-sectional study. A semistructured questionnaire, in
the English language, was designed for selfadministered data collection.
It comprised six sections: sociodemographic information, internet
accessibility, use of social media, experience of online sexual
harassment, student’s awareness and online behaviour.

Results: Around 66.5% of respondents reported having been exposed to
online sexual harassment at least once, and most of the respondents
(73.2%) had been exposed to online sexual harassment multiple times.
Just under twothirds (62.8%) of the respondents had been exposed to
online sexual harassment before they reached 18 years of age. The mean
age at which the young women experienced online sexual harassment was
18.94±1.79 years. Respondents studying in high school (10+2 level),
those residing in urban areas and those accepting friend requests on
social media from people they did not know offline were at higher risk
of experiencing frequent online sexual harassment (P=0.000, P=0.011, and
P=0.013 respectively). Conclusion: The rate of online sexual harassment
recorded was high. This shows an urgent need to address the problem;
universities and the government need to play a part. A new module of
comprehensive sexuality education for virtual communication is suggested
as an addition to current academic curriculums.
Prevalence and Factors Associated with Depression, Anxiety, and Stress among Undergraduate Management Students in Kathmandu, Nepal
Authors: Sharma Krishna , Shakya Anita
Published: September 2022

Background The commonness of psychological illness occurring within the
university curriculum, along with the socioeconomic or behavioral status
of students, is growing with the development of the deteriorating
education system. It is gradually developing into a mental health issue
among undergraduate students in Nepal and poses a significant challenge
for public health globally. This research study aimed to determine the
prevalence and factors associated with depression, anxiety, and stress
among undergraduate management students in Kathmandu, Nepal. Methods:
Out of 600 sample sizes, 516 students participated in the descriptive
cross-sectional study carried out among undergraduate management
students in Kathmandu. Depression, anxiety, and stress were measured
using the DASS21 (depression, anxiety, and stress scale 21) tool,
designed for self-administered data collection in Nepali and English.
The questionnaire comprises four sections: socio-demographic
information, depression, anxiety, and stress, to measure the different
emotional states of the student.

Findings: The overall prevalence of depression, anxiety, and stress was
found to be 57.8 %, 60.9 %, and 43 %, respectively, among
undergraduate management students in Kathmandu, and most female students
experienced it in contrast to male students. Almost all students (100
%) who participated in the research study have experienced the
unnecessary pressure of college studies as the most significant cause of
depression, anxiety, and stress. Students, those having less family
income (< 20000 NPR per month), those breaking up with loved
ones, those having no daily physical exercise, and having pressured
college studies were at higher risk of experiencing depression (P=0.004,
P=0.007, P=0.023, and P=0.000 respectively). The prevalence rate of
extremely severe depression, anxiety, and stress was about 9.1 %, 23.8
%, and 7 %, respectively. Conclusion: The study found that
undergraduate management students in Kathmandu had high rates of
anxiety, depression, and stress. Special attention and necessary
psychological health intervention from their respective
colleges/universities and government sectors are highly recommended.
An Efficient ADE-WLP-FDTD Method with new WLPs and Factorized Splitting scheme for Dispersive Media Simulation
Authors: Liu Gui-Ying , Chen Wei-Jun , Zhao Min
Published: September 2022

Based on an auxiliary differential equation (ADE) and new weighted
Laguerre polynomials (WLPs), an efficient 3-D finite-difference
time-domain method (FDTD) with factorized-splitting (FS) scheme is
proposed to calculate wave propagation in general dispersive materials.
In order to model general dispersive materials, the ADE technique is
introduced because it can establish the relationship between the
electric displacement vector and the electric field intensity. Using a
new temporal basis, the new WLPs can improve computational efficiency
and save computing resources. The FS scheme is used to efficiently solve
the huge sparse matrix equation of WLP-FDTD method into a sub-steps
procedure. A numerical example is given to verify the accuracy and the
efficiency of the proposed method. Compared with existing methods, the
results from the proposed method show its superiority for dispersive
media simulation.