bluuebunny/crossref_metadata_2025 huggingface dataset:
Heart Failure with Preserved Ejection Fraction: Time to Revisit the Stiff Heart
Authors: Vilaro Juan R. , Ahmed Mustafa , Aranda Juan M.
Published: February 2019

In the current era of cardiovascular disease, the diagnosis of heart failure with preserved ejection fraction (HFpEF) is a well-recognized clinical entity that is equally prevalent but distinctly different from heart failure with reduced ejection fraction (HFrEF). Despite normal EF patients with this disease have similar morbidity and mortality rates compared with HFrEF, as well as a rising rate of hospitalizations. The pathophysiology of HFpEF is incompletely understood. The number of therapies with proven efficacy at improving longterm cardiovascular outcomes is limited. Women with heart failure syndromes, particularly the elderly, are much more likely to have a HFpEF phenotype at the time of their diagnosis. The purpose of this paper is to review the epidemiology, pathophysiology, clinical features, and current management strategies in HFpEF, especially as it pertains to women.
Novel Imaging Approaches for the Diagnosis of Stable Ischemic Heart Disease in Women
Authors: Taqueti Viviany R.
Published: February 2019

Conventional recommendations for diagnostic testing for the evaluation of stable ischemic heart disease in women have largely paralleled those in men. Although they are designed primarily for the identification of obstructive coronary artery disease (CAD), traditional approaches can lead to overtesting in women without differentiating who is truly at risk. Several unique factors related to the presentation, diagnosis, and underlying pathophysiology of stable ischemic heart disease in women necessitate a more specific approach to the assessment of their risk, complete with separate guidelines when appropriate. This overview highlights how advanced noninvasive imaging tools, including cardiac computed tomography angiography, positron emission tomography, and cardiac magnetic resonance imaging, are enabling very sensitive assessments of anatomic atherosclerotic plaque burden, macrovessel- and microvessel-related ischemia, and myocardial fibrosis, respectively. Moving forward, effective diagnostic testing will need to identify women at high risk of adverse cardiovascular events (not anatomically obstructive CAD per se) without overtesting those at low risk. Judicious application of novel imaging approaches will be critical to broadening the definitions of CAD and ischemia to better reflect the whole spectrum of pathological phenotypes in women, including nonobstructive CAD and coronary microvascular dysfunction, and aid in the development of needed evidence-based strategies for their management.
Model-Based Manifest and Latent Composite Scores in Structural Equation Models
Authors: Rose Norman , Wagner Wolfgang , Mayer Axel , Nagengast Benjamin
Published: February 2019

Composite scores are commonly used in the social sciences as dependent and independent variables in statistical models. Typically, composite scores are computed prior to statistical analyses. In this paper, we demonstrate the construction of model-based composite scores that may serve as outcomes or predictors in structural equation models (SEMs). Model-based composite scores of manifest variables are useful in the presence of ignorable missing data, as full-information maximum likelihood estimation can be used for parameter estimation. Model-based composite scores of latent variables account for measurement error in the aggregated variables. We introduce the pseudo-indicator model (PIM) for the construction of three composite scores: (a) the sum score, (b) the weighted sum score, and (c) the average score of manifest and latent variables in SEM. The utility of manifest model-based composite scores in the case of missing values is shown by a simulation study. The use of multiple manifest and latent model-based composite scores in SEM is illustrated with data from motivation research.
Pancreatic prolactin receptor signaling regulates maternal glucose homeostasis
Authors: Nteeba Jackson , Kubota Kaiyu , Wang Wenfang , Zhu Hao , Vivian Jay L , Dai Guoli , Soares Michael J
Published: February 2019

Prolactin (PRL) signaling has been implicated in the regulation of glucose homeostatic adaptations to pregnancy. In this report, the PRL receptor (Prlr) gene was conditionally disrupted in the pancreas, creating an animal model which proved useful for investigating the biology and pathology of gestational diabetes including its impacts on fetal and placental development. In mice, pancreatic PRLR signaling was demonstrated to be required for pregnancy-associated changes in maternal β cell mass and function. Disruption of thePrlrgene in the pancreas resulted in fewer insulin-producing cells, which failed to expand appropriately during pregnancy resulting in reduced blood insulin levels and maternal glucose intolerance. This inability to sustain normal blood glucose balance during pregnancy worsened with age and a successive pregnancy. The etiology of the insulin insufficiency was attributed to deficits in regulatory pathways controlling β cell differentiation. Additionally, the disturbance in maternal blood glucose homeostasis was associated with fetal overgrowth and dysregulation of inflammation and PRL-associated transcripts in the placenta. Overall, these results indicate that the PRLR, acting within the pancreas, mediates maternal pancreatic adaptations to pregnancy. PRLR dysfunction is associated with glucose intolerance during pregnancy and pathological features consistent with gestational diabetes.
Role of neutrophil extracellular traps in chronic kidney injury induced by bisphenol-A
Authors: Tong Shiyun , Yang Shumin , Li Ting , Gao Rufei , Hu Jinbo , Luo Ting , Qing Hua , Zhen Qianna , Hu Renzhi , Li Xuan , Yang Yi , Peng Chuan , Li Qifu
Published: February 2019

Bisphenol-A (BPA) is a common environmental pollutant, and exposure to it is associated with proteinuria and may predict the progression of chronic kidney disease; however, the mechanism is not clear. Neutrophil extracellular traps (NETs) are a DNA skeleton coated with various proteases, and it is associated with various types of autoimmune nephritis. In this study, we examine whether NETs is involved in BPA-induced chronic kidney injury. In vivo, BPA exposure resulted in impaired renal function and altered renal morphology, including glomerular mesangial matrix expansion and increased renal interstitial fibroblast markers. Meanwhile, more dsDNA can be detected in the serum, and the NETs-associated proteins, MPO and citH3 were deposited in the renal system. In vitro, BPA and NETs treatment caused podocyte injury, a loss of marker proteins and disorder in the actin skeleton. After NETs inhibition via DNase administration, BPA-induced injuries were significantly relieved. In conclusion, the increase of NETosis in circulation and the renal system during BPA exposure suggests that NETs may be involved in BPA-induced chronic kidney injury.
La publicidad activa en la legislación estatal y gallega de transparencia
Authors: Fernández Rodríguez José Julio , Gude Fernández Ana
Published: February 2019

El trabajo hace un análisis de la publicidad activa en la LGT, en conexión con la norma básica (LETAI), lo que exige examinar críticamente cuestiones tales como los principios de publicidad activa, al información que debe publicarse, el portal de transparencia y las garantías. Asimismo, se realizan valoraciones prospectivas sobre cómo debe evolucionar esta cuestión.
Multiple Pathways Act Together To Establish Asymmetry of the Ventral Nerve Cord in Caenorhabditis elegans
Authors: Taylor Jesse , Hutter Harald
Published: February 2019

The central nervous system of most animals is bilaterally symmetrical. Closer observation often reveals some functional or anatomical left–right asymmetries. In the nematode Caenorhabditis elegans, the most obvious asymmetry in the nervous system is found in the ventral nerve cord (VNC), where most axons are in the right axon tract. The asymmetry is established when axons entering the VNC from the brain switch from the left to the right side at the anterior end of the VNC. In genetic screens we identified several mutations compromising VNC asymmetry. This includes alleles of col-99 (encoding a transmembrane collagen), unc-52/perlecan and unc-34 (encoding the actin modulator Enabled/Vasodilator-stimulated phosphoproteins). In addition, we evaluated mutants in known axon guidance pathways for asymmetry defects and used genetic interaction studies to place the genes into genetic pathways. In total we identified four different pathways contributing to the establishment of VNC asymmetry, represented by UNC-6/netrin, SAX-3/Robo, COL-99, and EPI-1/laminin. The combined inactivation of these pathways in triple and quadruple mutants leads to highly penetrant VNC asymmetry defects, suggesting these pathways are important contributors to the establishment of VNC asymmetry in C. elegans.
Quantum Mechanical Calculations of a Fusion Reaction for Some Selected Halo Systems
Authors: Majeed F. A. , Mahdi F. A.
Published: February 2019

The effect of the breakup channel on the fusion reaction of weakly bound systems by means of a quantum mechanical approach has been discussed. The total fusion reaction cross-section Ofus, the fusion barrier distribution Dfus and the mean angular momentum ⟨L⟩ for the systems 6He+64Zn, 6He+209Bi, 8B+58Ni and 11Be+238U have been calculated. The inclusion of the breakup channel is found to be very essential in the calculations of the fusion reaction for systems involving light halo nuclei especially below the Coulomb barrier Vb. The results of the calculations of Ofus, Dfus and ⟨L⟩ agrees quite well with the corresponding experimental data.
Interfacial Layers and the Shear Elasticity of the Collagen–Water System
Authors: Bulavin L. A. , Zabashta Yu. F. , Vergun L. Yu. , Svechnikova O. S. , Yefimenko A. S.
Published: February 2019

A hypothesis has been put forward that, in collagen hydrogels, there exist interfacial water layers surrounding the collagen helices. A model of interfacial water layer is proposed which does not contradict experimental data on the shear elasticity of collagen hydrogels. Such layers can exist in a loose connective tissue and prove its supporting function.
Titans of Ukraine. UPTI–Laboratory No. 1–KhPTI
Authors: Tan’shyna A.
Published: February 2019

On the basis of archival sources and the recollections of the employees of the Ukrainian Physical-Technical Institute, Laboratory No. 1, and Kharkiv Physical-Technical Institute, some episodes from the history of the National Science Center “Kharkov Institute of Physics and Technology” are described.
Zimbabwe Post Election Violence: Motlanthe Commission of Inquiry 2018
Authors: Mungwari Teddy
Published: February 2019

Zimbabwe held its national elections on 30 July 2018. The electoral process was generally peaceful until 1 August 2018, when demonstrators took to the streets of Harare demanding the immediate release of the presidential election results. Arguably, the police failed to contain the situation and sought the assistance of the military which fired live ammunition to unarmed civilians. By end of 1 August 2018, at least six (6) people had been tragically killed; injury of thirty-five (35), and extensive damage and destruction of property had been caused. Following these incidents, on 12 September 2018, the President of the Republic of Zimbabwe, His Excellency Emmerson Dambudzo Mnangagwa, appointed a Commission of Inquiry in terms of Section 2(1) of the Commission of Inquiry Act [Chapter 10:07] through Proclamation 6of 2018 published in Statutory Instrument 181 of 2018, to investigate matters of public welfare arising out of the tragic events in Harare on 1 August 2018. This article argues that the Motlanthe Commission of Inquiry was biased against main opposition. The article concluded that the coverage of the public hearings was polarized and that Zimbabwe is a divided and polarized state. This article contributes towards policy and reform changes.
Comunicação que constitui e transforma os sujeitos: agir comunicativo em Jürgen Habermas, ação dialógica em Paulo Freire e os estudos organizacionais
Authors: Andrade Luís Fernando Silva , Alcântara Valderí de Castro , Pereira José Roberto
Published: February 2019

Resumo Este artigo apresenta contribuições de Jürgen Habermas e Paulo Freire para a constituição de sujeitos crítico-reflexivos e suas implicações nos processos de ensino/pesquisa/extensão no campo dos Estudos Organizacionais. Mostramos que intersubjetividade e dialogicidade são condições para o entendimento entre sujeitos e é justamente por meio delas que ocorre sua constituição em um processo que é dialógico, pedagógico e político. Freire e Habermas oferecem elementos para desconstruir a lógica instrumental dominante e fornecem bases para a reconstrução de possibilidades inéditas/viáveis de formas de organizar e gerir. A partir disso, este artigo destaca a importância dos Estudos Organizacionais ampliarem o foco das possibilidades de ensino/pesquisa/extensão e direciona-os para um engajamento comunicativo e dialógico, ultrapassando as fronteiras das universidades. Essa reconstrução indica aos pesquisadores que participem de diferentes arenas públicas, do debate e da construção de problemas, em processos de resistência, da visibilidade e dramatização de questões problemáticas. Nos caminhos de Freire e Habermas, os Estudos Organizacionais não podem apenas desenvolver uma crítica à distância: é preciso coparticipar, co-agir, co-operar e coconstruir com os públicos em que se engajam.
Razão e Administração: revisitando alguns elementos fundamentais
Authors: Santos Laís Silveira , Serafim Mauricio C. , Pinheiro Daniel Moraes , Ames Maria Clara Figueiredo Dalla Costa
Published: February 2019

Resumo As ações e os processos administrativos parecem estar em um período pós-racional, no qual a racionalidade se tornou uma palavra mal compreendida, sendo a ação racional comumente associada ao cientificismo e à tecnocracia. Acreditamos que esse estereótipo pode ter um fundo de verdade, mas é, sobretudo, baseado em um mal-entendido fundamental que buscamos esclarecer. Assim, o objetivo deste ensaio teórico é revisitar o conceito de razão, base de toda ciência social, a partir da argumentação de que ela é una e indivisível, sendo denominada aqui razão lúcida. Após um resgate da concepção clássica de razão e sua transavaliação do período moderno, essa contextualização forneceu bases para responder a seguinte pergunta: “como formular uma razão da práxis apta a guiar a própria práxis pelos caminhos de um procedimento racional?”. Sugerimos que a resposta se encontra na razão lúcida, constituída pela unidade entre a prudência (phrónesis), pautada por uma lógica contextual e instrumental, e as intenções, baseadas na razão em seu sentido substantivo. É a partir desse conceito que podemos compreender a tensão experimentada nas organizações, inerente à vida da razão, por meio de uma atitude parentética. Concluímos que, assim como a razão enquanto característica humana é única, a discussão da racionalidade no contexto das organizações também deve ser pautada pela não separação literal entre duas ou mais racionalidades, mas reconhecendo a ação administrativa como racional, em seu sentido singular, com as múltiplas faculdades que a compõem.
Gestionando la innovación desde la óptica de los estudios de ciencia, tecnología y sociedad: por una perspectiva constructivista y crítica de la gestión de la innovación
Authors: Espinosa-Cristia Juan Felipe
Published: February 2019

Resumen El presente trabajo elabora una discusión y reflexión teórica sobre la manera en que la gestión de la innovación puede comprenderse e investigarse. Esta discusión se realiza sobre la base del concepto de gestión de la innovación que han definido Dodgson, Gann y Phillips (2013). El texto analiza, en particular, el impacto de la epistemología y comprensión del mundo que se presentan en la literatura de la gestión de la innovación, utilizando para ello la óptica de un estudio constructivista -Ciencia, Tecnología y Sociedad- y crítico de la misma. El análisis muestra la posibilidad abrir nuevos rumbos para la gestión de la innovación. Como resultado, se muestra la necesidad de comprender performativamente, reflexivamente el fenómeno de la gestión de la innovación, operación que conlleva la necesaria agrupación entre el capital y el trabajo para una comprensión cabal de la gestión de la innovación.
Norma Técnica de Padronização e as Delegacias das Mulheres em Santa Catarina
Authors: Oliveira Ana Claudia Delfini Capistrano de , Ghisi Ana Silvia Serrano
Published: February 2019

Resumo: O artigo apresenta os resultados de uma pesquisa realizada com delegados/as que atuam nas Delegacias Especializadas de Atendimento às Mulheres em 19 regiões de Santa Catarina. Os objetivos principais foram compreender o perfil dos delegados/as e analisar a adequação das atividades policiais e das condições estruturais administrativas das Delegacias em relação à Norma Técnica de Padronização das Delegacias Especializadas de Atendimento à Mulher. A abordagem metodológica apoia-se em dados quantitativos obtidos com a utilização de um questionário online, respondido pelos delegados/as. Os resultados da pesquisa mostram que as delegacias são majoritariamente comandadas por delegados homens, que as condições estruturais e atividades executadas nas referidas unidades policiais estão aquém do previsto na Norma.
Encontros e despedidas: migração de mulheres militares da Aeronáutica
Authors: Araujo Thais Ferreira de , Roso Adriane
Published: February 2019

Resumo: Este estudo, de caráter qualitativo, objetivou conhecer os significados das experiências de migração de mulheres no contexto militar. Utilizando um enfoque psicossocial crítico e recorrendo, em especial, às teorias de gênero e a teoria das Representações Sociais, buscou-se, especificamente, compreender de que forma essas experiências contribuíram para a construção da subjetividade. Por meio da narrativa de mulheres militares, concluímos que a experiência de tornar-se uma mulher só, em um lugar desconhecido, está carregada de representações e significados que reforçam permanências em uma cultura de subordinação de gênero, em que as mulheres permanecem em lugares de não poder.
Desvelando afinidades através das diferenças: saberes e estéticas pós/descoloniais
Authors: Harris Leila Assumpção
Published: February 2019

Resumo: Sob o viés do feminismo multicultural, os conceitos de relacionalidade, de posicionamento dos discursos e das interseccionalidades de opressões são instrumentais para um melhor entendimento das múltiplas perspectivas que norteiam as práticas feministas atuais, ancoradas em saberes e estéticas pós e descoloniais. Nosso objetivo é colocar em pauta as práticas e estéticas políticas adotadas por mulheres de lugares geográficos e sociais bastante diversos. A produção artística que desenvolvem através de linguagens e narrativas variadas promove possibilidades de fomentar poéticas de resistência e descolonização de gênero que desafiam nossa compreensão tradicional sobre o estético, o político e o epistemológico.
Efeito da levodopa na mecânica coclear e no sistema auditivo eferente de indivíduos com doença de Parkinson
Authors: Lopes Marcia da Silva , Melo Ailton de Souza , Corona Ana Paula , Nóbrega Ana Caline
Published: February 2019

RESUMO Objetivo Analisar o efeito da levodopa na dinâmica coclear, bem como na via eferente olivococlear medial de indivíduos com doença de Parkinson idiopática (DP). Método Indivíduos com e sem DP, acompanhados em um hospital universitário, realizaram a pesquisa das emissões otoacústicas por produto de distorção (EOAPD) e do efeito inibitório das EOAPD (EIEOA) na presença de ruído contralateral. Foram estabelecidas as medidas de correlação entre os resultados das EOAPD e do EIEOA com estágio Hoehn&Yahr (H&Y), dose diária de levodopa e tempo de diagnóstico da DP. Além disso, as medidas eletroacústicas foram comparadas entre os indivíduos sem DP e com DP, estratificados de acordo com a dose de levodopa administrada diariamente. Resultados Foi identificada correlação fraca e negativa entre a amplitude das EOAPD com a dose diária de levodopa e correlações positivas, de força moderada e fraca, entre o EIEOA com a dose diária de levodopa e o tempo de diagnóstico da DP, respectivamente. A amplitude das EOAPD foi maior nos indivíduos com DP em uso de levodopa ≤ 600 miligramas quando comparada à de indivíduos sem DP e com DP, em uso de dose superior. Já o EIEOA foi menor nos indivíduos em uso de doses ≤ 600 miligramas, quando comparado aos demais grupos. Conclusão Doses diárias de levodopa iguais ou inferiores a 600 mg/dia aumentam as respostas mecanotransdutoras cocleares nas frequências de 2 e 3 kHz, enquanto que a ação dos sistemas eferentes olivococleares é reduzida nesta região.
Extração e caracterização da lignina proveniente do pré-tratamento de biomassa para produção de etanol de 2a geração
Authors: Bes Káren , Lemões Juliana Silva , Silva Cláudia Fernanda Lemons e , Silva Sérgio Delmar dos Anjos e
Published: February 2019

RESUMO A biomassa destaca-se como um dos poucos recursos disponíveis com potencial de desenvolvimento de biorrefinarias para a inclusão de rotas alternativas sustentáveis na produção de energia e produtos químicos. A lignina é um subproduto do pré-tratamento da biomassa na produção de etanol de segunda geração, basicamente composta de cadeias de carbono e que pode ter alto valor agregado. Contudo, tem sido tradicionalmente utilizada para geração de energia por queima direta. Sendo assim, o objetivo do presente estudo foi investigar a influência do pH na precipitação do licor negro, variando o pH de 1 a 7, bem como caracterizar os componentes da sua estrutura química para possíveis usos futuros. Após a obtenção da massa precipitada, procedeu-se às análises espectrofotométricas no infravermelho e no ultravioleta, além da quantificação de fenóis totais, nas frações sólidas e líquidas das ligninas provenientes dos diferentes pH. Os resultados demonstram que as maiores concentrações de lignina foram obtidas nos menores valores de pH. As análises instrumentais indicaram diferenças nos componentes de cada lignina, sugerindo que sua composição química é influenciada pela alteração do pH. Ainda, a concentração total de fenóis no sobrenadante das amostras foi menor em pH mais baixos, confirmando que há maiores concentrações desses na fração sólida das ligninas.
Biossorção de íons Cr(III) de soluções aquosas sintéticas e efluente de curtume utilizando a macrófita aquática Pistia stratiotes
Authors: Rocker Cristiana , Caetano Josiane , Gonçalves Júnior Affonso Celso , Mees Juliana Bortoli Rodrigues , Dragunski Douglas Cardoso
Published: February 2019

RESUMO O cromo é um metal tóxico amplamente utilizado em processos industriais, por isso a constante preocupação com os efluentes líquidos gerados. Uma vez lançados sem o devido tratamento podem comprometer a qualidade do corpo receptor. Este trabalho teve por objetivo analisar o processo de biossorção na remoção de íons Cr(III) de soluções aquosas sintéticas e efluente de curtume utilizando como biossorvente a macrófita aquática Pistia stratiotes in natura (PN) e quimicamente modificada (PM) com hidróxido de sódio e ácido cítrico. Realizou-se o preparo, a caracterização dos biossorventes e os experimentos de biossorção. Os estudos de equilíbrio indicaram que a capacidade máxima de biossorção foi de 58,16 e 19,80 mg g-1 para PM e PN, respectivamente. Nos testes utilizando efluente bruto de curtume, a remoção de cromo foi de 28,26% para ambos os biossorventes, e no efluente da lagoa de tratamento biológico, a maior taxa de remoção do metal foi obtida pelo biossorvente PM, com 65,44%. Os resultados demonstraram que a utilização de P. stratiotes como biossorvente apresenta-se como uma alternativa eficaz e de baixo custo, porém estudos complementares são necessários a fim de avaliar sua aplicação em escala real.
AGENESIS OF THE POSTERIOR ARCH OF THE ATLAS: AN INCIDENTAL FINDING IN A POLYTRAUMATIZED PATIENT
Authors: Fernandes Rodrigo Mota Pacheco , Pires Lucas Alves Sarmento , Manaia Jorge Henrique Martins , Paula Rafael Cisne de , Babinski Marcio Antonio
Published: February 2019

ABSTRACT The first cervical vertebra is subject to numerous anatomical variations. One of these is posterior arch agenesis, which is classified into five distinct morphological types. Together, all types of posterior arch agenesis comprise only 4% of atlas variations. Furthermore, complete agenesis of the posterior arch associated with the presence of the posterior tubercle is rare. This work reports a case of posterior arch agenesis with the presence of the posterior tubercle in a 33 year-old male victim of a motor vehicle collision. Despite being asymptomatic, this anatomical variation can present with headaches and neck pain. It is mostly found as an incidental finding in imaging studies performed by the emergency team and, as a result, it is often misdiagnosed as a C1 fracture. Knowledge of the variations relating to the first cervical vertebra is therefore essential to avoid delays in diagnosis and treatment of polytraumatized patients. Level of evidence V; Case report.
IMPACT OF THE MIS-TLIF TECHNIQUE ON THE SPINOPELVIC PARAMETERS OF PATIENTS WITH LUMBAR ARTHRODESIS
Authors: Menezes Cristiano Magalhães , Aguiar Leonardo Fernandes , Arruda André de Oliveira , Cardoso Rodrigo Vieira , Valle Germano Senna Oliveira do , Lima Rodrigo Souza , Bringel Mário Leite , Fernandes Felipe Miranda Mendonça , Pérez Joint Halley Guimbard
Published: February 2019

ABSTRACT Objective: To evaluate the influence of the MIS-TLIF technique on the spinopelvic parameters of patients submitted to lumbar arthrodesis up to three levels for the treatment of vertebral degenerative conditions without deformity. Methods: Retrospective radiographic evaluation of 52 patients submitted to the surgical treatment of lumbar arthrodesis using the MIS-TLIF technique in up to three levels. The spinopelvic parameters – pelvic incidence (PI), pelvic tilt(PT), lumbar lordosis (LL), segmental lordosis (Lseg), and the difference between lumbar lordosis and pelvic incidence (LL-PI mismatch) were analyzed in orthostatic lateral radiographs in the pre- and postoperative periods, with a minimum follow-up of 1 year. The patients were divided into three groups: PI <45°, PI between 45° and 55° and PI >55°. Results: Sixty-nine operated levels were evaluated in 15 patients with PI <45°, 19 with PI between 45° and 55° and 18 with PI >55°. The mean value of the pelvic incidence was 52.3° (± 11.5), lumbar lordosis 46.1° (pre)/45.6° (post); segmental lordosis 20.3° (pre)/20.6° (post); pelvic tilt 18.5° (pre)/18.2° (post); “mismatch” (PI-LL) 7° (pre)/ 6.6° (post), with no statistical difference among all parameters (p>0.05). Conclusions: The MIS-TLIF technique had no influence on postoperative spinopelvic parameters of patients undergoing lumbar arthrodesis surgery. Level of evidence: III. Retrospective comparative study.
A quick reference table for extreme flood hydrology methods at UK dams
Authors: Pether Rachel , Fraser Robert
Published: February 2019

Since the introduction of the Flood Studies Report by Natural Environment Research Council in 1975 there have been a number of changes to the methodology for calculation of extreme flood events at reservoirs. Therefore when presented with historical reservoir flood studies, reservoir owners and panel engineers may wish to understand the extent of changes that have occurred to the methodology since these flow rates were calculated. The table below is a quick reference guide to the changes that have occurred since 1975.
Head injuries - let's face the facts
Authors: Lambert M
Published: February 2019

Head injuries - let's face the facts
Miltenyi MACS Bead Isolation v1
Authors: DK Moore Dannielle , G Loxton Andre
Published: February 2019

This protocol includes the step-by-step used for isolation of a cell popultation of interest using MACS bead technology. The kits used for this protocol were obtained from Miltenyi. Miltenyi isolation kits are based on a simple process, in which biotin conjugated antibody-labelled mononuclear cells are separated from unlabeled cells via a column in the presence of a magnetic field.
PCR Reaction Optimization v3
Authors: Schackart Kenneth
Published: February 2019

How to run nucleic acid amplification using the Thermo scientific PCR Master Mix kit. Each reaction produces 50 μL. For the original protocol, look at: .
Reduplication, Fusion, Inflexion—The Phonetic Proof of Moe Culture in Modern Chinese Language
Authors: Zhuang Xiaotong , Nie Daxin
Published: February 2019

The present paper takes the popular language expressions in Chinese relating to the Moe Culture after its introduction from Japanese as the research object, aiming to analyze the important role of phonetic adjustment in enhancing the effect of Moe culture from the perspective of linguistics. It points out that reduplication, fusion and inflexion may enhance the effect of Moe culture through three specific mechanisms. The conclusion of the present study provides an angle and facts for clarifying the contact between Moe Culture and Chinese language under the development of modern society.
Corrective Feedback in the Saudi EFL Writing Context: A New Perspective
Authors: Al-wossabi Sami Ali Nasr
Published: February 2019

Corrective feedback (CF) in writing classes has been a central issue in the field of SLA. Various SLA studies recommended that raising the awareness towards EFL students' perceptions and attitudes of CF practices might lead to more effective learning of writing skills and more successful teaching methods in the L2 classroom (Ellis, 2009; Ferris, 2007; Lee, 1997; Pawlak, 2014). The present paper proposes a new perspective towards the use of CF practices in writing classes at the Saudi EFL context. The study, therefore, aims at collecting necessary data on students' attitudes towards the proposed practices of CF and finding out whether such practices would be positively or negatively perceived by students. It also aims at finding out whether or not such practices are beneficial for students. The results showed approval on the use of the proposed practices of CF among the majority of participants. Participants were motivated and exhibited patent ability for self-correction.
Developing Critical Reading Skills through Stylistic Analysis in Integrated College English Classroom
Authors: Liu Kang
Published: February 2019

Reading is a dynamic and interactive process between the reader and the writer, which goes beyond the literal study of the text. It requires readers to actively engage in analysis, judgment and evaluation of information. However, integrated college English classes focus more on students’ language proficiency and restrain students’ critical competence. The deficiency of critical thinking skills and disposition defects the students’ power of creativity and innovation competence. So it is obligated for college English teachers to improve critical awareness and employ stylistic analysis method to help students to develop critical reading skills, building up students’ ability to predict, reason, analyze and evaluate the reading materials.
From Sensibility to Sense—An Analysis on the Shift of Marianne’s Views on Marriage in Sense and Sensibility
Authors: Zhang Yuchao
Published: February 2019

Jane Austen is an excellent female writer in the United Kingdom. Many of her works appeal to generation after generation of readers. She wrote and published six novels in total. Sense and Sensibility was one of her popular novels and first named as Elinor and Marianne. Elder sister Elinor is a rational girl who can control her temper appropriately. She loves Edward very much. However, the younger sister Marianne is very emotional. She pursues romantic love and fails to control her temper after the lovelorn. After experiencing many setbacks, Marianne understands many principles and corrects her childish viewpoints. Luckily, both of them get their true love finally.By researching original book and other literatures as well as analyzing the shift of Marianne’s behaviors and views on marriage from sensibility to sense, we can understand wise attitudes towards marriage. That is to say, when a woman chooses her Mr. Right, she should be more rational in love. This paper has great guiding importance for current women to seek their guidance in love. The paper will lead us to find what the rational views on marriage are and what we should do in marriage.
Outcomes of combination therapy for stage IIA–IIIB cervical cancer
Authors: Reyes Santiago D. K. , Khadzhimba A. S. , Sobolev I. V. , Ilyin A. A. , Maksimov S. Ya.
Published: February 2019

Objective: to analyze treatment outcomes in patients with stage IIA–IIIB cervical cancer.

Materials and methods. The study included 278 women with stage IIA–IIIB cervical cancer. Study participants were divided into 2 groups. Group 1 comprised 165 patients who received chemoradiotherapy + surgery (radical hysterectomy). Patients in group 2 received standard radiotherapy.

Results. Patients receiving combination therapy demonstrated better overall and relapse-free survival compared to those receiving standard treatment.

Conclusion. Both publications of other authors and our own results suggest high efficacy and safety of combination therapy for stage IIA–IIIB cervical cancer.
Lymphatic cysts after gynecological cancer surgery: risk factors, diagnosis and treatment
Authors: Rogovskaya Т. Т. , Berlev I. V.
Published: February 2019

Lymphatic cysts, also known as lymphocele, are one of the most common complications after pelvic and paraaortic lymph node dissection in patients with gynecological cancers. Despite the high incidence of this complication, no specific guidelines on the diagnosis and treatment of lymphocele have been developed so far. This article analyzes the incidence of lymphatic cysts, risk factors, and currently available options for their diagnosis and treatment.
MEGATRENDS OF DEVELOPMENT OF GLOBAL INNOVATION NETWORKS
Authors: Rylach N.
Published: February 2019

Under the megatrend, we mean large-scale technological, economic, social, political changes that occur slowly, but in the long run, when they are rooted, they substantially and permanently affect most of the processes in society. Such relative stability in the trajectory of the main forces of change can predict some elements of medium and long-term future changes. The article investigates such megatrends of the development of global innovation networks as the structural nature of the global innovation system, the development of systemic interconnections in the field of innovation, the interaction of national innovation systems and global, the internationalization of innovation activity, and the paradigm of "open innovation". The methodological principles and structural elements of the concept of the national innovation system are determined in the paper, the connection of national innovation systems with the phenomenon of internationalization of the innovation sphere is explored. The theoretical principles of the phenomenon of internationalization of innovation activity are investigated, as well as the preconditions for the emergence of the concept of "open innovation" and its current trends have been established. The concept of open innovation is an important precondition for the emergence and functioning of global innovation networks. The paper analyzes the genesis and specificity of the phenomenon of global innovation networks, outlines their structure and dynamics. It has been determined that global innovation networks play an important role in the development of the modern world economy, as they stimulate international cooperation in the innovation sphere, transfer of knowledge to the world economy and general scientific and technological development and growth of world production.
Öznitelik Seçme ve Makine Öğrenmesi Yöntemleriyle Eğitmen Performansının Tahmin Edilmesi
Authors: ÇİFÇİ Fatih , KALELİ Cihan , ÜNAL Serkan
Published: February 2019

Günümüzde hayatın her sektöründe işlenen veri miktarının

artması, veri madenciliğin giderek daha popüler hale gelmesine yol açmış ve

yüksek miktarda verinin artan bir karmaşıklıkta işlenmesi ihtiyacı doğmuştur.

Finanstan, sağlığa, savunmadan eğitime onlarca sektörün sorunlarını çözmek

adına gün geçtikçe farklı yöntemler geliştirilmekte, sosyal, ekonomik, bilimsel

birçok problemin çözümü adına veri madenciliği yöntemlerine başvurulmaktadır.

Eğitilen ve eğiten sayısının gün geçtikçe arttığı eğitim sektöründe ise,

sistemin başarısının geliştirilebilmesi için, gerek eğitilen gerekse

eğitimcilerinin performanslarının takip edilmesi ve kıymetlendirilmesi

ihtiyacı, eğitimsel veri madenciliği kavramını doğurmuştur. Bu alanda yapılan

çalışmalar genel olarak, öğrenci performansı konularına yoğunlaştığından,

eğitmen performansı konusunda daha çok çalışmaya ihtiyaç duyulmaktadır.

Eğitimsel veri madenciliği alanında öznitelik seçme ile birleştirilmiş makine

öğrenmesi kullanan çalışmaların genel olarak öğrenci performansı üzerine

yoğunlaştığı, ancak az sayıdaki çalışmanın eğitmen performansı üzerinde durduğu

görülmüştür. Bu çalışmamızda, eğitmen performansının eğitimsel veri madenciliği

yöntemleriyle nasıl tespit edilebileceği üzerinde durulmuştur.  Çalışma kapsamında Gazi Üniversitesi

öğrencilerinin eğitmenleri hakkında doldurdukları bir Likert Ölçekli Anket veri

seti üzerinde çalışılmış, çeşitli öznitelik indirgeme algoritmaları ve farklı

makine öğrenme yöntemleriyle veri seti kıymetlendirilmiş ve eğitmenlerin

performansları tahmin edilmiştir. Elde edilen sonuçlara göre genetik algoritma

ile öznitelik seçmenin, kullanılan veri seti için diğer yöntemlere kıyasla en

iyi sonucu verdiğini göstermiş ve 33 tane öznitelik yerine 19 öznitelik

kullanılabileceği ortaya çıkarılmıştır. Genetik algoritma ile birlikte makine

öğrenmesi yöntemi olarak derin öğrenme kullanımı ile birlikte %97,70 bir tahmin

doğruluk performansına ulaşılmış ve bu değerin tüm özniteliklerin kullanılması

ile elde edilebilecek değerden yüksek olduğu görülmüştür. Bu çalışmayı

diğerlerinden farklı kılan özelliği ise, indirgenmiş öznitelik sayısı ve makine

öğrenmesini birleştirmesinin yanında, eğitmen performanslarının sıralanması

işlemini de somut olarak yapmasıdır.
Reliability and Validity Work of Conflict Resolution Skill Scale
Authors: GÜRDOĞAN-BAYIR Ömür , GÜLTEKİN Mehmet
Published: February 2019

Bu çalışmada ilkokul dördüncü sınıf öğrencilerinin çatışma çözme becerisi ölçülmesine ilişkin geçerli ve güvenilir bir ölçme aracının geliştirilmesi amaçlanmıştır. Ölçek kapsamına alınacak maddelerin yazımında alanyazında benzer konuda yer alan ölçeklerden yararlanılmıştır. Alanyazında çatışma çözme becerisine yönelik yapılan sınıflandırmalar ve uzman görüşleri göz önünde bulundurularak belirlenen boyutlara toplam 38 madde yazılarak madde havuzu oluşturulmuştur. Ölçek açımlayıcı faktör analizi için 277, doğrulayıcı faktör analizi için ise 146 öğrenciye uygulanmıştır. Açımlayıcı faktör analizi sonucunda ölçeğin “uzlaşmaya başvurma” ve “şiddete başvurma” faktörlerinden oluştuğu ve toplam varyansın %49.89’unu açıkladığı sonucuna ulaşılmıştır. Ayrıca ölçeğin belirlenen iki faktörlü yapısı doğrulayıcı faktör analizi sonucunda bir model olarak doğrulanmıştır. Ölçeğin güvenirlik çalışmaları ise Cronbach Alpha katsayısı, test yarılama,   madde toplam korelasyonları ve alt-üst %27’lik grupların karşılaştırılması yoluyla yapılmıştır. Elde edilen değerler sonucunda ölçeğin güvenilir olduğu belirlenmiştir. Bu kapsamda geliştirilen Çatışma Çözme Becerisi Ölçeği’nin ilkokul dördüncü sınıf öğrencilerinin çatışma çözme becerilerinin belirlenmesinde geçerli ve güvenilir bir ölçme aracı olduğu sonucu ortaya çıkmıştır.
Institutional Determinants of Higher Education Students’ International Mobility within the Erasmus Programme Countries
Authors: Bartha Zoltán , S. Gubik Andrea
Published: February 2019

One of the major EU policy objectives is to enhance the international mobility of students. The Leuven Communiqué published in 2009 set an objective of increasing the ratio of European Higher Education Area (EHEA) higher education graduates participating in a study or a training period abroad to at least 20% by 2020. However, currently the majority of European Union Member States perform significantly below the target in this respect. Also, since a low number ofstudents are interested in mobility programmes, the funds of the Erasmus-type student mobility programs remain unused.This study focuses on highlighting the factors that represent barriers to student participation in mobility programs. After conducting a literature review on international student mobility and presenting major statistics describing outbound mobility, this study investigates factors related to institutional components of the higher education system that affect the international mobility of Erasmus young people. Among the explanatory factors related to Erasmus-type student mobility, cultural factors including Hofstede’s indulgence and uncertainty avoidance seem to have the greatest influence on studentmobility intentions in Europe. The findings revealed that better planned Erasmus processes (pre-, during and postmobility activities such as departure, course choice, staying in a host country, etc.) and better communicated career opportunities and labour market values of the mobility could considerably contribute to an increase in the number of outbound students. One of the main lessons learned from the conducted analyses is that Europe’s rich cultural diversity needs to be considered in the course of promoting the Erasmus Programme in Europe. In addition to adopting common communication, promotion and direction strategies, programmes need to be elaborated that take national specificities into account.
Speech/music classification using PLP and SVM
Authors: R Thiruven Gatanadhan
Published: February 2019

Automatic audio classification is very useful in audio indexing; content based audio retrieval and online audio distribution. This paper deals with the Speech/Music classification problem, starting from a set of features extracted directly from audio data. Automatic audio classification is very useful in audio indexing; content based audio retrieval and online audio distribution. The accuracy of the classification relies on the strength of the features and classification scheme. In this work Perceptual Linear Prediction (PLP) features are extracted from the input signal. After feature extraction, classification is carried out, using Support Vector Model (SVM) model. The proposed feature extraction and classification models results in better accuracy in speech/music classification.
#WhyWeDoResearch: Raising research awareness and opportunities for patients, public and staff through Twitter
Authors: Yhnell Emma , Smith Hazel A. , Walker Kay , Whitehouse Claire L.
Published: February 2019

The #WhyWeDoResearch campaign was set up in 2014 and was originally planned to run locally, in Norfolk, at the James Paget University Hospitals NHS Foundation Trust (JPUH) for 12 days in December. Within four days, the campaign was being utilized nationally by other trusts and charities.
By the New Year of 2015 it became international and had reached Australia and Canada. The intended audience for the campaign is broad and includes: patients, the general public, all staff working in health care and/or research including (but not limited to) National Health Service (NHS), commercial
companies, charities and schools. The campaign has become a community where patients, staff and public alike can share their voices about health research on an equal playing field. Each year, to coincide with International Clinical Trials Day (ICTD) on 20 May, a #WhyWeDoResearch 'Tweetfest'
is hosted. This includes a number of 'tweetchats' at set times throughout the Tweetfest. Tweetchats are hosted by experts in particular diseases or other areas. Patients and patient groups are included in this group of experts. This article uses the #WhyWeDoResearch campaign annual Tweetfest
to demonstrate how social media can be utilized to raise awareness of health research around the world.
Theatrical performance as a public pedagogy of solidarity for intercultural learning
Authors: Harvey Lou , McCormick Brad , Vanden Katy , Collins Ree , Suarez Patricia
Published: February 2019

This article is a post-hoc reflective theorization of a public engagement event based on research into UK-based international students' experiences of learning English. The event was a work-in-progress theatrical performance called The Translator, devised and produced by theatre
company Cap-a-Pie and associates, and staged on two nights in June 2017 in Leeds. Our aim was to create an active learning experience for the public about how they relate to 'otherness' and difference in communication, and how they think about their own responses to difficult communicative
situations. Lou first outlines her understanding of intercultural learning (Harvey, 2016, following Bakhtin, 1981), her engagement with Gert Biesta's pedagogy in the interest of publicness, and Biesta's own dialogue with Hannah Arendt on freedom and plurality. We then present filmed
rehearsal footage and a written description of some of the scenes from The Translator. This is followed by audience responses, which demonstrate the audience's discomfort arising from different aspects of misunderstanding in the performance and how this prompted them to consider their
own 'otherness' and their responsibilities for successful communication. The subsequent discussion draws on Lou's recent thinking in critical human rights theory to demonstrate how The Translator functioned as a public pedagogy of solidarity, in which the audience reflected on
our mutual responsibility to work to understand each other regardless of our cultural backgrounds and the languages we speak.
Actividad fotocatalítica de recubrimientos de óxidos de titanio depositados por pulverización catódica reactiva
Authors: Orozco-Rodríguez Diana , Cernyb Pavel , Cvcerk Ladislav
Published: February 2019

El objetivo de este proyecto es medir la actividad fotocatalitica de capas delgadas de óxidos de Titanio depositadas por Pulverización Catódica con Magnetrón. Los recubrimientos se depositaron en sustratos de silicón utilizando una mezcla de gases Ar – O2 y titanio puro como target. Como resultados, se obtuvo una composición química de Ti1-xOx donde x varía de 2,25 a 0,45. De acuerdo a los resultados de las pruebas de Adhesión, la carga mínima obtenida fue de 14,43 N mientras que la mayor fue de 72,01 N. Los resultados de las pruebas para la actividad fotocatalítica mostraron que las muestras no eran reactivas ya que no se obtuvo un cambio de color en el ácido naranja, sustancia en la cual fueron sumergidas, luego de que las muestras estuvieran expuestas a la luz ultravioleta.
Caracterización bromatológica de pellets elaborados a partir de subproductos agropecuarios para la alimentación de bovinos
Authors: López-Varela David
Published: February 2019

Con el propósito de caracterizar nutricionalmente una mezcla de Yuca (YC) (Manihot esculenta),Gallinaza (GA), Harina de Soya (HS), Harina de Arroz (HA), Aceite de Soya (AS), Cultivo deLactobacilos (CL), se realizó un análisis bromatológico a pellets a partir de estas materiasprimas, con los siguientes niveles de incorporación en la mezcla, (YC) 15%, (GA) 30%, (HS)15%, (HA) 30%, (AS) 5%, (CL) 5%. El estudio bromatológico se llevó a cabo en el Departamentode Zootecnia (DZO) de la Universidad Federal de Viçosa (UFV), Brasil. Se realizaron pruebaspara Proteína Cruda (PC), Materia Seca (MS), Cenizas (CEN), Fibra Detergente Neutro (FDN),Fibra Detergente Acido (FDA), Extracto Etéreo (EE), Materia Orgánica (MO), CarbohidratosNo Fibrosos (CNF), para los cuales se obtuvieron los siguientes resultados: PC: 13,16%, MS:93,61%, CEN: 29,98%, FDN: 30,91%, FDNcp: 16,88%, FDA: 21,20%, FDAcp: 11,90%, EE: 12%,MO: 70,02%, CNF: 27,98%. Se concluye que los pellets de la mezcla de subproductos presentancaracterísticas nutricionales con alto potencial para ser utilizados como una alternativa dealimentación para ganado bovino en tiempos de escasez de alimento a partir de subproductosagropecuarios disponibles en toda la Región Huetar Norte de Costa Rica.