bluuebunny/crossref_metadata_2025 huggingface dataset:
Nanostructured Lipid Carriers Can Enhance Oral Absorption of Khellin, a Natural Pleiotropic Molecule
Authors: Vanti Giulia , Muti Lucrezia , D’Ambrosio Mario , Grifoni Lucia , Bergonzi Maria Camilla , Luceri Cristina , Bilia Anna Rita
Published: December 2021

A novel formulation based on nanostructured lipid carriers (NLCs) was developed to increase solubility and intestinal absorption of khellin. K-NLCs were prepared with stearic acid, hempseed oil, Brij S20, and Labrafil M 1944 CS, using the emulsification-ultrasonication method. Developed nanoparticles were chemically and physically characterized by liquid chromatography, light scattering techniques, and electron microscopy. The size, about 200 nm, was optimal for oral delivery, and the polydispersity index (around 0.26), indicated high sample homogeneity. Additionally, K-NLCs showed a spherical morphology without aggregation by microscopic analysis. The encapsulation efficiency of khellin was about 55%. In vitro release studies were carried out in media with different pH to mimic physiological conditions. K-NLCs were found to be physically stable in the simulated gastric and intestinal fluids, and they preserved about 70% of khellin after 6 h incubation. K-NLCs were also successfully lyophilized testing different lyoprotectants, and obtained freeze-dried K-NLCs demonstrated good shelf life over a month. Lastly, permeability studies on Caco-2 cells were performed to predict khellin passive diffusion across the intestinal epithelium, demonstrating that nanoparticles increased khellin permeability by more than two orders of magnitude. Accordingly, developed NLCs loaded with khellin represent a versatile formulation with good biopharmaceutical properties for oral administration, possibly enhancing khellin’s bioavailability and therapeutic effects.
Scalarane Sesterterpenoids with Antibacterial and Anti-Proliferative Activities from the Mushroom Neonothopanus nambi
Authors: Wisetsai Awat , Lekphrom Ratsami , Bua-art Sureeporn , Suebrasri Thanapat , Boonlue Sophon , Tontapha Sarawut , Amornkitbamrung Vittaya , Senawong Thanaset , Schevenels Florian T.
Published: December 2021

Seven undescribed scalarane sesterterpenoids, nambiscalaranes B–H (1–7), together with two known compounds, nambiscalarane (8) and aurisin A (9) were isolated from the cultured mycelium of the luminescent mushroom Neonothopanus nambi. Their structures were elucidated by thorough analysis of their 1D and 2D NMR spectroscopic data. The absolute configurations of 1–8 were determined by electronic circular dichroism (ECD) calculations and optical rotation measurements. The isolated sesterterpenoids were evaluated against A549, HT29, HeLa, and HCT-116 cancer cell lines, and against five bacterial strains. Compounds 3, 5, and 7 showed strong cytotoxicity against HCT-116 cell line, with IC50 values ranging from 13.41 to 16.53 µM, and showed no cytotoxicity towards Vero cells. Moreover, compound 8 inhibited the growth of Bacillus subtilis with a MIC value of 8 µg/mL, which was equivalent to the MIC value of the standard kanamycin.
Nanogold Particles Suppresses 5-Flurouracil-Induced Renal Injury: An Insight into the Modulation of Nrf-2 and Its Downstream Targets, HO-1 and γ-GCS
Authors: El-Sherbiny Mohamed , Fahmy Eslam K. , Eisa Nada H. , Said Eman , Elkattawy Hany A. , Ebrahim Hasnaa Ali , Elsherbiny Nehal M. , Ghoneim Fatma M.
Published: December 2021

The development of the field of nanotechnology has revolutionized various aspects in the fields of modern sciences. Nano-medicine is one of the primary fields for the application of nanotechnology techniques. The current study sheds light on the reno-protective impacts of gold nano-particles; nanogold (AuNPs) against 5-flurouracil (5-FU)-induced renal toxicity. Indeed, the use of 5-FU has been associated with kidney injury which greatly curbs its therapeutic application. In the current study, 5-FU injection was associated with a significant escalation in the indices of renal injury, i.e., creatinine and urea. Alongside this, histopathological and ultra-histopathological changes confirmed the onset of renal injury. Both gene and/or protein expression of nuclear factor erythroid 2–related factor 2 (Nrf-2) and downstream antioxidant enzymes revealed consistent paralleled anomalies. AuNPs administration induced a significant renal protection on functional, biochemical, and structural levels. Renal expression of the major sensor of the cellular oxidative status Nrf-2 escalated with a paralleled reduction in the renal expression of the other contributor to this axis, known as Kelch-like ECH-associated protein 1 (Keap-1). On the level of the effector downstream targets, heme oxygenase 1 (HO-1) and gamma-glutamylcysteine synthetase (γ-GCS) AuNPs significantly restored their gene and protein expression. Additionally, combination of AuNPs with 5-FU showed better cytotoxic effect on MCF-7 cells compared to monotreatments. Thus, it can be inferred that AuNPs conferred reno-protective impact against 5-FU with an evident modulatory impact on Nrf-2/Keap-1 and its downstream effectors, HO-1 and γ-GCS, suggesting its potential use in 5-FU regimens to improve its therapeutic outcomes and minimize its underlying nephrotoxicity.
Deuterium Isotope Effects on Acid-Base Equilibrium of Organic Compounds
Authors: Liu Meiyi , Gao Jiali
Published: December 2021

Deuterium isotope effects on acid–base equilibrium have been investigated using a combined path integral and free-energy perturbation simulation method. To understand the origin of the linear free-energy relationship of ΔpKa=pKaD2O−pKaH2O versus pKaH2O, we examined two theoretical models for computing the deuterium isotope effects. In Model 1, only the intrinsic isotope exchange effect of the acid itself in water was included by replacing the titratable protons with deuterons. Here, the dominant contribution is due to the difference in zero-point energy between the two isotopologues. In Model 2, the medium isotope effects are considered, in which the free energy change as a result of replacing H2O by D2O in solute–solvent hydrogen-bonding complexes is determined. Although the average ΔpKa change from Model 1 was found to be in reasonable agreement with the experimental average result, the pKaH2O dependence of the solvent isotope effects is absent. A linear free-energy relationship is obtained by including the medium effect in Model 2, and the main factor is due to solvent isotope effects in the anion–water complexes. The present study highlights the significant roles of both the intrinsic isotope exchange effect and the medium solvent isotope effect.
The Adsorption Behavior of Gas Molecules on Co/N Co–Doped Graphene
Authors: Xie Tingyue , Wang Ping , Tian Cuifeng , Zhao Guozheng , Jia Jianfeng , Zhao Chenxu , Wu Haishun
Published: December 2021

Herein, we have used density functional theory (DFT) to investigate the adsorption behavior of gas molecules on Co/N3 co–doped graphene (Co/N3–gra). We have investigated the geometric stability, electric properties, and magnetic properties comprehensively upon the interaction between Co/N3–gra and gas molecules. The binding energy of Co is −5.13 eV, which is big enough for application in gas adsorption. For the adsorption of C2H4, CO, NO2, and SO2 on Co/N–gra, the molecules may act as donors or acceptors of electrons, which can lead to charge transfer (range from 0.38 to 0.7 e) and eventually change the conductivity of Co/N–gra. The CO adsorbed Co/N3–gra complex exhibits a semiconductor property and the NO2/SO2 adsorption can regulate the magnetic properties of Co/N3–gra. Moreover, the Co/N3–gra system can be applied as a gas sensor of CO and SO2 with high stability. Thus, we assume that our results can pave the way for the further study of gas sensor and spintronic devices.
Improved Light Harvesting of Fiber-Shaped Dye-Sensitized Solar Cells by Using a Bacteriophage Doping Method
Authors: Koo Sung-Jun , Kim Jae Ho , Kim Yong-Ki , Shin Myunghun , Choi Jin Woo , Oh Jin-Woo , Lee Hyung Woo , Song Myungkwan
Published: December 2021

Fiber-shaped solar cells (FSCs) with flexibility, wearability, and wearability have emerged as a topic of intensive interest and development in recent years. Although the development of this material is still in its early stages, bacteriophage-metallic nanostructures, which exhibit prominent localized surface plasmon resonance (LSPR) properties, are one such material that has been utilized to further improve the power conversion efficiency (PCE) of solar cells. This study confirmed that fiber-shaped dye-sensitized solar cells (FDSSCs) enhanced by silver nanoparticles-embedded M13 bacteriophage (Ag@M13) can be developed as solar cell devices with better PCE than the solar cells without them. The PCE of FDSSCs was improved by adding the Ag@M13 into an iodine species (I−/I3−) based electrolyte, which is used for redox couple reactions. The optimized Ag@M13 enhanced FDSSC showed a PCE of up to 5.80%, which was improved by 16.7% compared to that of the reference device with 4.97%.
High-Level Oxygen Reduction Catalysts Derived from the Compounds of High-Specific-Surface-Area Pine Peel Activated Carbon and Phthalocyanine Cobalt
Authors: Zhao Lei , Lan Ziwei , Mo Wenhao , Su Junyu , Liang Huazhu , Yao Jiayu , Yang Wenhu
Published: December 2021

Non-platinum carbon-based catalysts have attracted much more attention in recent years because of their low cost and outstanding performance, and are regarded as one of the most promising alternatives to precious metal catalysts. Activated carbon (AC), which has a large specific surface area (SSA), can be used as a carrier or carbon source at the same time. In this work, stable pine peel bio-based materials were used to prepare large-surface-area activated carbon and then compound with cobalt phthalocyanine (CoPc) to obtain a high-performance cobalt/nitrogen/carbon (Co-N-C) catalyst. High catalytic activity is related to increasing the number of Co particles on the large-specific-area activated carbon, which are related with the immersing effect of CoPc into the AC and the rational decomposed temperature of the CoPc ring. The synergy with N promoting the exposure of CoNx active sites is also important. The Eonset of the catalyst treated with a composite proportion of AC and CoPc of 1 to 2 at 800 °C (AC@CoPc-800-1-2) is 1.006 V, higher than the Pt/C (20 wt%) catalyst. Apart from this, compared with other AC/CoPc series catalysts and Pt/C (20 wt%) catalyst, the stability of AC/CoPc-800-1-2 is 87.8% in 0.1 M KOH after 20,000 s testing. Considering the performance and price of the catalyst in a practical application, these composite catalysts combining biomass carbon materials with phthalocyanine series could be widely used in the area of catalysts and energy storage.
Nanoimprinted and Anodized Templates for Large-Scale and Low-Cost Nanopatterning
Authors: Navas David , Trabada David G. , Vázquez Manuel
Published: December 2021

Nanopatterning to fabricate advanced nanostructured materials is a widely employed technology in a broad spectrum of applications going from spintronics and nanoelectronics to nanophotonics. This work reports on an easy route for nanopatterning making use of ordered porous templates with geometries ranging from straight lines to square, triangular or rhombohedral lattices, to be employed for the designed growth of sputtered materials with engineered properties. The procedure is based on large-scale nanoimprinting using patterned low-cost commercial disks, as 1-D grating stamps, followed by a single electrochemical process that allows one to obtain 1-D ordered porous anodic templates. Multiple imprinting steps at different angles enable more complex 2-D patterned templates. Subsequently, sputtering facilitates the growth of ferromagnetic antidot thin films (e.g., from 20 to 100 nm Co thick layers) with designed symmetries. This technique constitutes a non-expensive method for massive mold production and pattern generation avoiding standard lithographical techniques. In addition, it overcomes current challenges of the two-stage electrochemical porous anodic alumina templates: (i) allowing the patterning of large areas with high ordering and/or complex antidot geometries, and (ii) being less-time consuming.
Green Hydrogels Composed of Sodium Mannuronate/Guluronate, Gelatin and Biointeractive Calcium Silicates/Dicalcium Phosphate Dihydrate Designed for Oral Bone Defects Regeneration
Authors: Gandolfi Maria Giovanna , Zamparini Fausto , Valente Sabrina , Parchi Greta , Pasquinelli Gianandrea , Taddei Paola , Prati Carlo
Published: December 2021

Innovative green, eco-friendly, and biologically derived hydrogels for non-load bearing bone sites were conceived and produced. Natural polysaccharides (copolymers of sodium D-mannuronate and L-guluronate) with natural polypeptides (gelatin) and bioactive mineral fillers (calcium silicates CaSi and dicalcium phosphate dihydrate DCPD) were used to obtain eco-sustainable biomaterials for oral bone defects. Three PP-x:y formulations were prepared (PP-16:16, PP-33:22, and PP-31:31), where PP represents the polysaccharide/polypeptide matrix and x and y represent the weight % of CaSi and DCPD, respectively. Hydrogels were tested for their chemical-physical properties (calcium release and alkalizing activity in deionized water, porosity, solubility, water sorption, radiopacity), surface microchemistry and micromorphology, apatite nucleation in HBSS by ESEM-EDX, FT-Raman, and micro-Raman spectroscopies. The expression of vascular (CD31) and osteogenic (alkaline phosphatase ALP and osteocalcin OCN) markers by mesenchymal stem cells (MSCs) derived from human vascular walls, cultured in direct contact with hydrogels or with 10% of extracts was analysed. All mineral-filled hydrogels, in particular PP-31:31 and PP-33:22, released Calcium ions and alkalized the soaking water for three days. Calcium ion leakage was high at all the endpoints (3 h–28 d), while pH values were high at 3 h–3 d and then significantly decreased after seven days (p < 0.05). Porosity, solubility, and water sorption were higher for PP-31:31 (p < 0.05). The ESEM of fresh samples showed a compact structure with a few pores containing small mineral granules agglomerated in some areas (size 5–20 microns). PP-CTRL degraded after 1–2 weeks in HBSS. EDX spectroscopy revealed constitutional compounds and elements of the hydrogel (C, O, N, and S) and of the mineral powders (Ca, Si and P). After 28 days in HBSS, the mineral-filled hydrogels revealed a more porous structure, partially covered with a thicker mineral layer on PP-31:31. EDX analyses of the mineral coating showed Ca and P, and Raman revealed the presence of B-type carbonated apatite and calcite. MSCs cultured in contact with mineral-filled hydrogels revealed the expression of genes related to vascular (CD31) and osteogenic (mainly OCN) differentiation. Lower gene expression was found when cells were cultured with extracts added to the culture medium. The incorporation of biointeractive mineral powders in a green bio-derived algae-based matrix allowed to produce bioactive porous hydrogels able to release biologically relevant ions and create a suitable micro-environment for stem cells, resulting in interesting materials for bone regeneration and healing in oral bone defects.
Crystallization in Zirconia Film Nano-Layered with Silica
Authors: Larsen Brecken , Ausbeck Christopher , Bennet Timothy F. , DeSalvo Gilberto , DeSalvo Riccardo , LeBohec Tugdual , Linker Seth , Mondin Marina , Neilson Joshua
Published: December 2021

Gravitational waves are detected using resonant optical cavity interferometers. The mirror coatings’ inherent thermal noise and photon scattering limit sensitivity. Crystals within the reflective coating may be responsible for either or both noise sources. In this study, we explored crystallization reduction in zirconia through nano-layering with silica. We used X-ray diffraction (XRD) to monitor crystal growth between successive annealing cycles. We observed crystal formation at higher temperatures in thinner zirconia layers, indicating that silica is a successful inhibitor of crystal growth. However, the thinnest barriers break down at high temperatures, thus allowing crystal growth beyond each nano-layer. In addition, in samples with thicker zirconia layers, we observe that crystallization saturates with a significant portion of amorphous material remaining.
The Fingerprints of Resonant Frequency for Atomic Vacancy Defect Identification in Graphene
Authors: Chu Liu , Shi Jiajia , Souza de Cursi Eduardo
Published: December 2021

The identification of atomic vacancy defects in graphene is an important and challenging issue, which involves inhomogeneous spatial randomness and requires high experimental conditions. In this paper, the fingerprints of resonant frequency for atomic vacancy defect identification are provided, based on the database of massive samples. Every possible atomic vacancy defect in the graphene lattice is considered and computed by the finite element model in sequence. Based on the sample database, the histograms of resonant frequency are provided to compare the probability density distributions and interval ranges. Furthermore, the implicit relationship between the locations of the atomic vacancy defects and the resonant frequencies of graphene is established. The fingerprint patterns are depicted by mapping the locations of atomic vacancy defects to the resonant frequency magnitudes. The geometrical characteristics of computed fingerprints are discussed to explore the feasibility of atomic vacancy defects identification. The work in this paper provides meaningful supplementary information for non-destructive defect detection and identification in nanomaterials.
Coaxial Electrospinning Construction Si@C Core–Shell Nanofibers for Advanced Flexible Lithium-Ion Batteries
Authors: Zeng Li , Xi Hongxue , Liu Xingang , Zhang Chuhong
Published: December 2021

Silicon (Si) is expected to be a high-energy anode for the next generation of lithium-ion batteries (LIBs). However, the large volume change along with the severe capacity degradation during the cycling process is still a barrier for its practical application. Herein, we successfully construct flexible silicon/carbon nanofibers with a core–shell structure via a facile coaxial electrospinning technique. The resultant Si@C nanofibers (Si@C NFs) are composed of a hard carbon shell and the Si-embedded amorphous carbon core framework demonstrates an initial reversible capacity of 1162.8 mAh g−1 at 0.1 A g−1 with a retained capacity of 762.0 mAh g−1 after 100 cycles. In addition, flexible LIBs assembled with Si@C NFs were hardly impacted under an extreme bending state, illustrating excellent electrochemical performance. The impressive performances are attributed to the high electric conductivity and structural stability of the porous carbon fibers with a hierarchical porous structure, indicating that the novel Si@C NFs fabricated using this electrospinning technique have great potential for advanced flexible energy storage.
Can Plant Materials Be Valuable in the Treatment of Periodontal Diseases? Practical Review
Authors: Gościniak Anna , Paczkowska-Walendowska Magdalena , Skotnicka Agnieszka , Ruchała Marek A. , Cielecka-Piontek Judyta
Published: December 2021

Periodontal diseases are one of the most significant challenges in dental health. It is estimated that only a few percent of the worldwide population have entirely healthy teeth, and according to WHO, oral diseases may affect up to 3.5 billion people worldwide. One of the most serious oral diseases is periodontitis, an inflammatory disease affecting periodontal tissues, caused by pathogenic bacteria and environmental factors such as the ageing population, abuse of tobacco products, and lack of adequate oral hygiene due low public awareness. Plant materials are widely and successfully used in the management of many conditions, including periodontitis. Plant materials for periodontitis exhibit antibacterial, anti-inflammatory, antioxidant activities and affect the periodontium structure. Numerous studies demonstrate the advantages of phytotherapy for periodontitis relief and indicate the usefulness of Baikal skullcap root, Pomegranate fruit peel and root cortex, Tea leaves, Chamomile flowers, Magnolia bark, Blackberry leaves and fruits, Cranberry fruits and Lippia sidoides essential oil. This review aims to analyze the use and applicability of selected plant materials in periodontitis management since it is of paramount importance to evaluate the evidence of the traditionally used plant materials in light of continuously growing interest in phytotherapy and its adjuvant role in the treatment of periodontitis.
Therapeutic Potential of Injectable Nano-Mupirocin Liposomes for Infections Involving Multidrug-Resistant Bacteria
Authors: Cern Ahuva , Bavli Yaelle , Hod Atara , Zilbersheid Daniel , Mushtaq Shazad , Michael-Gayego Ayelet , Barasch Dinorah , Feinstein Rotkopf Yael , Moses Allon E. , Livermore David M. , Barenholz Yechezkel
Published: December 2021

Antibiotic resistance is a global health threat. There are a few antibiotics under development, and even fewer with new modes of action and no cross-resistance to established antibiotics. Accordingly, reformulation of old antibiotics to overcome resistance is attractive. Nano-mupirocin is a PEGylated nano-liposomal formulation of mupirocin, potentially enabling parenteral use in deep infections, as previously demonstrated in several animal models. Here, we describe extensive in vitro profiling of mupirocin and Nano-mupirocin and correlate the resulting MIC data with the pharmacokinetic profiles seen for Nano-mupirocin in a rat model. Nano-mupirocin showed no cross-resistance with other antibiotics and retained full activity against vancomycin-, daptomycin-, linezolid- and methicillin- resistant Staphylococcus aureus, against vancomycin-resistant Enterococcus faecium, and cephalosporin-resistant Neisseria gonorrhoeae. Following Nano-mupirocin injection to rats, plasma levels greatly exceeded relevant MICs for >24 h, and a biodistribution study in mice showed that mupirocin concentrations in vaginal secretions greatly exceeded the MIC90 for N. gonorrhoeae (0.03 µg/mL) for >24 h. In summary, Nano-mupirocin has excellent potential for treatment of several infection types involving multiresistant bacteria. It has the concomitant benefits from utilizing an established antibiotic and liposomes of the same size and lipid composition as Doxil®, an anticancer drug product now used for the treatment of over 700,000 patients globally.
Raman Spectroscopy Enables Non-Invasive Identification of Mycotoxins p. Fusarium of Winter Wheat Seeds
Authors: Moskovskiy Maksim N. , Sibirev Aleksey V. , Gulyaev Anatoly A. , Gerasimenko Stanislav A. , Borzenko Sergey I. , Godyaeva Maria M. , Noy Oleg V. , Nagaev Egor I. , Matveeva Tatiana A. , Sarimov Ruslan M. , Simakin Alexander V.
Published: December 2021

Identification of specific mycotoxins p. Fusarium contained in infected winter wheat seeds can be achieved by visually recognizing their distinctive phenotypic species. The visual identification (ID) of species is subjective and usually requires significant taxonomic knowledge. Methods for the determination of various types of mycotoxins of the p. Fusarium are laborious and require the use of chemical invasive research methods. In this research, we investigate the possibility of using Raman spectroscopy (RS) as a tag-free, non-invasive and non-destructive analytical method for the rapid and accurate identification of p. Fusarium. Varieties of the r. Fusarium can produce mycotoxins that directly affect the DNA, RNA and chemical structure of infected seeds. Analysis of spectra by RS methods and chemometric analysis allows the identification of healthy, infected and contaminated seeds of winter wheat with varieties of mycotoxins p. Fusarium. Raman seed analysis provides accurate identification of p. Fusarium in 96% of samples. In addition, we present data on the identification of carbohydrates, proteins, fiber and other nutrients contaminated with p. Fusarium seeds obtained using spectroscopic signatures. These results demonstrate that RS enables rapid, accurate and non-invasive screening of seed phytosanitary status.
Thermal Fringe Formation during a Hologram Recording Using a Dry Photopolymer
Authors: Bruder Friedrich-Karl , Fäcke Thomas , Rölle Thomas
Published: December 2021

In this study we investigated the undesired but possible fringe formation during the recording of large size holographic optical elements (HOE) using a dry photopolymer. We identified the deformation of the recording element during hologram exposure as the main source for this fringe formation. This deformation is caused mainly by the one-sided heating of the recording element, namely, the dry photopolymer–recording plate stack. It turned out that the main source for this heating was the heat of polymerization in the dry photopolymer released during the exposure interval. These insights were translated into a physical model with which quantitative predictions about thermal fringe formation can be made depending on the actual HOE recording geometry, recording conditions and characteristics of the dry photopolymer. Using this model, different types of large size HOEs, used as components to generate a steerable confined view box for a 23” diagonal size display demonstrator, could be recorded successfully without thermal fringe formation. Key strategies to avoid thermal fringe formation deduced from this model include balancing the ratio of lateral recording plate dimension R to its thickness h, recording the power density P or equivalently the exposure time texp at a fixed recording dosage E, and most importantly recording the the linear coefficient of thermal expansion (CTE) of the recording plate material. Suitable glass plates with extremely low CTE were identified and used for recording of the above-mentioned HOEs.
Three-Axis Tension-Measuring Vitreoretinal Forceps Using Strain Sensor for Corneal Surgery
Authors: Yang Seongjin , Kim Suhyeon , Hong Seong , Jeon Hyungkook , Cho Seong , Lim Geunbae
Published: December 2021

Precise motion control is important in robotic surgery, especially corneal surgery. This paper develops a new tension-measurement system for forceps used in corneal surgery, wherein contact force is applied only to a specific location for precise control, with precise movements detected by attaching a nano-crack sensor to the corresponding part. The nano-crack sensor used here customizes the working range and sensor sensitivity to match the strain rate of the tip of the forceps. Therefore, the tension in the suture can be sufficiently measured even at suture failure. The printed circuit board attached to the bottom of the system is designed to simultaneously collect data from several sensors, visualizing the direction and magnitude of the tension in order to inform the surgeon of how much tension is being applied. This system was verified by performing pig-corneal suturing.
Synthesis and Spectroscopic Analyses of New Polycarbonates Based on Bisphenol A-Free Components
Authors: Wnuczek Krystyna , Puszka Andrzej , Podkościelna Beata
Published: December 2021

This paper discusses a new synthesis of bisphenol A-free polycarbonates based on four aliphatic-aromatic systems. In the first stage, different types of monomers (with/without sulfur) derived from diphenylmethane were synthesized. Then, new polycarbonates were prepared in the reactions with diphenyl carbonate (DPC) by transesterification and polycondensation reactions. Three different catalysts (zinc acetate, 4-(dimethylamino)pyridine and benzyltriethylammonium chloride) were tested. The structures of the compounds were confirmed by Nuclear Molecular Resonance spectroscopy (NMR) in each stage. The chemical structures of the obtained polycarbonates were verified by means of Attenuated Total Reflectance Fourier Transform infrared spectroscopy (ATR-FTIR). The presence of a carbonyl group in the infrared spectrum confirmed polycarbonate formation. Thermal studies by differential scanning calorimetry (DSC) were carried out to determine the melting temperatures of the monomers. A gel permeation chromatography analysis (GPC) of the polycarbonates was performed in order to investigate their molar masses. Thermal analysis proved the purity of the obtained monomers; the curves showed a characteristic signal of melting. The obtained polycarbonates were characterized as having high resistance to organic solvents, including tetrahydrofuran. The GPC analysis proved their relatively large molar masses and their low dispersity.
Selected Properties of Cement Bound Spruce and Larch Bark Bio-Aggregates
Authors: Urstöger Johannes , Barbu Marius Cătălin , Pacher Thomas , Petutschnigg Alexander , Jorda Johannes , Tudor Eugenia Mariana
Published: December 2021

The aim of this study is to investigate the suitability of spruce and larch bark for the production of cement-bonded composites. At the beginning of this research, the curing behaviour of the admixtures was quantified with temperature profiles when testing spruce, larch, pine and poplar bark, to determine the compatibility between the components of the bio-aggregates, to analyse the cement curing and to establish which bark species should be successfully included in cement bonded composites. Considering the results, it was observed that the average densities of 600–700 kg/m3 of bio-aggregates are 40–55% lower than that of established products on the market, although spruce and larch bark are in a similar range. The situation is different for the compressive strength, as larch bark showed up to 30% higher values than spruce bark. This study revealed also different hardening characteristics of the two cement types used as binders for spruce and larch bark. The results of this study demonstrated that tree bark of Picea abies and Larix decidua Mill. can be successfully utilized for the production of a cement-bonded composite material.
A Multi-Analytical Approach for Studying the Effect of New LED Lighting Systems on Modern Paints: Chemical Stability Investigations
Authors: Pintus Valentina , Szabó Ferenc , Noel Tóth Dávid , Wieland Karin , Csuti Péter , Anghelone Marta , Santorelli Ottavia , Salvadori Carlotta , Haisch Christoph , Sterflinger Katja , Schreiner Manfred
Published: December 2021

This study aims to investigate the chemical stability of some modern paint samples exposed to a new Light Emitting Diode (LED)-lighting system and a halogen lamp by using micro-attenuated total reflectance of Fourier transform infrared spectroscopy (µ-ATR-FTIR), µ-Raman, pyrolysis—gas chromatography/mass spectrometry (Py-GC/MS), and thermally assisted hydrolysis and methylation of GC/MS (THM-GC/MS). Those investigations were performed before and after the exposure of the samples to lightings for 1250, 2400, 3300, and 5000 h. The results obtained with µ-Raman spectroscopy show the high stability of the selected inorganic pigments after the exposure to the lighting systems; while similar to the UV/Vis/NIR results reported in a previous study, µ-ATR-FTIR and THM-GC/MS results evidence greater chemical changes occurring principally on the linseed oil binder-based mock-ups among the acrylic and alkyd-based samples. Moreover, principal component analyses (PCA) and hierarchical cluster analyses (HCA) of THM-GC/MS results highlight that those changes were mostly dependent on the exposure time and on the type of pigment, while being independent of the lighting system used. Finally, semi-quantitative µ-ATR-FTIR results show slight pigment enrichment at the paint surface due to the auto and photo-oxidative degradation of the linseed oil binder.
Application of Failure Criteria on Plywood under Bending
Authors: Merhar Miran
Published: December 2021

In composite materials, the use of failure criteria is necessary to determine the failure forces. Various failure criteria are known, from the simplest ones that compare individual stresses with the corresponding strength, to more complex ones that take into account the sign and direction of the stress, as well as mutual interactions of the acting stresses. This study investigates the application of the maximum stress, Tsai-Hill, Tsai-Wu, Puck, Hoffman and Hashin criteria to beech plywood made from a series of plies of differently oriented beech veneers. Specimens were cut from the manufactured boards at various angles and loaded by bending to failure. The mechanical properties of the beech veneer were also determined. The specimens were modelled using the finite element method with a composite modulus and considering the different failure criteria where the failure forces were calculated and compared with the measured values. It was found that the calculated forces based on all failure criteria were lower than those measured experimentally. The forces determined using the maximum stress criterion showed the best agreement between the calculated and measured forces.
A Versatile Equilibrium Method for the Synthesis of High-Strength, Ladder-like Polyphenylsilsesquioxanes with Finely Tunable Molecular Parameters
Authors: Ershova Tatyana O. , Anisimov Anton A. , Temnikov Maxim N. , Novikov Maxim A. , Buzin Mikhail I. , Nikiforova Galina G. , Dyuzhikova Yulia S. , Ushakov Ivan E. , Shchegolikhina Olga I. , Muzafarov Aziz M.
Published: December 2021

A versatile equilibrium method for synthesizing ladder-like polyphenylsilsesquioxanes (L-PPSQs) with various molecular weights (from 4 to 500 kDa) in liquid ammonia was developed. The effect of diverse parameters, such as temperature, monomer concentration, reaction time, addition or removal of water from the reaction medium, on the polycondensation process was determined. The molecular weight characteristics and structure of the L-PPSQ elements obtained were determined by GPC, 1H, 29Si NMR, IR spectroscopy, viscometry, and PXRD methods. The physicochemical properties of L-PPSQs were determined by TGA and mechanical analyses.
Preparation of Graphene Oxide/Cellulose Composites with Microcrystalline Cellulose Acid Hydrolysis Using the Waste Acids Generated by the Hummers Method of Graphene Oxide Synthesis
Authors: Miao Yuanyuan , Wang Xiuya , Liu Yixing , Liu Zhenbo , Chen Wenshuai
Published: December 2021

The Hummers method is the most commonly used method to prepare graphene oxide (GO). However, many waste acids remain in the raw reaction mixture after the completion of this reaction. The aim of this study was to reuse these waste acids efficiently. In this study, microcrystalline cellulose (MCC) was directly dissolved in the mixture after the high-temperature reaction of the Hummers method. The residual acid was used to hydrolyze MCC, and the graphene oxide/microcrystalline cellulose (GO/MCC) composites were prepared, while the acid was reused. The effects of MCC addition (0.5 g, 1.0 g, and 1.5 g in 20 mL) on the properties of the composites were discussed. The structure, composition, thermal stability, and hydrophobicity of GO/MCC composites were characterized and tested by SEM, XRD, FTIR, TG, and contact angle tests. The results showed that MCC could be acid hydrolyzed into micron and nano-scale cellulose by using the strong acidity of waste liquid after GO preparation, and it interacted with the prepared GO to form GO/MCC composites. When the addition amount of MCC was 1 g, the thermal stability of the composite was the highest due to the interaction between acid-hydrolyzed MCC and GO sheets. At the same time, the hydrophobic property of the GO/MCC composite is better than that of the GO film. The freeze-dried GO/MCC composites are more easily dispersed in water and have stronger stability.
Non-Isothermal Free-Surface Viscous Flow of Polymer Melts in Pipe Extrusion Using an Open-Source Interface Tracking Finite Volume Method
Authors: Fernandes Célio , Fakhari Ahmad , Tukovic Željko
Published: December 2021

Polymer extrudate swelling is a rheological phenomenon that occurs after polymer melt flow emerges at the die exit of extrusion equipment due to molecular stress relaxations and flow redistributions. Specifically, with the growing demand for large scale and high productivity, polymer pipes have recently been produced by extrusion. This study reports the development of a new incompressible non-isothermal finite volume method, based on the Arbitrary Lagrangian–Eulerian (ALE) formulation, to compute the viscous flow of polymer melts obeying the Herschel–Bulkley constitutive equation. The Papanastasiou-regularized version of the constitutive equation is employed. The influence of the temperature on the rheological behavior of the material is controlled by the Williams–Landel–Ferry (WLF) function. The new method is validated by comparing the extrudate swell ratio obtained for Bingham and Herschel–Bulkley flows (shear-thinning and shear-thickening) with reference data found in the scientific literature. Additionally, the essential flow characteristics including yield-stress, inertia and non-isothermal effects were investigated.
Use of Novel Non-Toxic Bismuth Catalyst for the Preparation of Flexible Polyurethane Foam
Authors: El Khezraji Said , Thakur Suman , Raihane Mustapha , López-Manchado Miguel Angel , Belachemi Larbi , Verdejo Raquel , Lahcini Mohammed
Published: December 2021

Foam products are one of the largest markets for polyurethane (PU) and are heavily used in many sectors. However, current PU formulations use highly toxic and environmentally unfriendly production processes. Meanwhile, the increasing environmental concerns and regulations are intensifying the research into green and non-toxic products. In this study, we synthesized flexible polyurethane foam (PUF) using different weight percentages (0.025%, 0.05% and 0.1%) of a non-toxic bismuth catalyst. The bismuth-catalyzed foams presented a well evolved cellular structure with an open cell morphology. The properties of the bismuth-catalyzed flexible PUF, such as the mechanical, morphological, kinetic and thermal behaviors, were optimized and compared with a conventional tin-catalyzed PUF. The bismuth-catalyst revealed a higher isocyanate conversion efficiency than the stannous octoate catalyst. When comparing samples with similar densities, the bismuth-catalyzed foams present better mechanical behavior than the tin-catalyzed sample with similar thermal stability. The high solubility of bismuth triflate in water, together with its high Lewis acidity, have been shown to benefit the production of PU foams.
Albanian Migrants in Cyclades: Contact with Mental Health Services and Implications for Practice
Authors: Pantelidou Stella , Manolesou Sofia , Apostolopoulou Antigoni , Giannakopoulou Katerina , Stylianidis Stelios
Published: December 2021

The purpose of this study was to examine the potential differences between Albanian migrants and Greeks in the islands of Paros and Antiparos with regard to seeking help from the local public mental health service, namely the Mobile Mental Health Unit of NE Cyclades Islands (EPAPSY-NGO). The study’s instruments include the Global Assessment of Functioning (GAF) and a questionnaire for recording psychosocial profile data and information concerning contact with the services. The results showed that significantly less Albanian migrants contacted the mental health services in the past in comparison to Greeks. When using the service, the Albanians were more likely to see a psychiatrist in the Unit, rather than a psychologist-psychotherapist, and they more often received prescriptions for medication. There was a significantly higher dropout rate among Albanian migrants. This study highlights the different aspects of access and use of mental health services among Albanian migrants compared with native residents. Further research should focus on the factors related to early dropouts and difficulties accessing mental health services in rural areas, in order to develop more focused and effective interventions and improve the quality of care provided.
Best Available Technology for P-Recycling from Sewage Sludge—An Overview of Sewage Sludge Composting in Austria
Authors: Stürmer Bernhard , Waltner Melanie
Published: December 2021

In order to close the phosphorus cycle in the long term, efficient recycling processes are necessary to ensure that this critical nutrient can be returned to arable land. Sewage sludge recycling is of particular importance due to the relatively high phosphorus content of sewage sludge. In this article, the current recycling paths of Austrian sewage sludge are highlighted, focusing on the advantages and limitations of sewage sludge composting. In addition to nutrient contents, pollutant loads were also analyzed in order to also discuss the limitations of this recycling pathway. Therefore, data from Austrian composting plants with focus on sewage sludge are used. The results show that the currently relevant pollutants (heavy metals) are predominantly below the limits prescribed for recycling and spreading on arable land. However, in order to decide on a recycling path at an early stage, a pollutant monitoring system must be in place. Due to pollution, mono-incineration with subsequent phosphorus recovery is also currently being discussed in Austria. Mono-incineration can represent an important component of sewage sludge disposal, because some sewage sludges are not suitable for composting due to potential environmental hazards. Therefore, it is important that evidence-based limit values and measures for the reduction in pollutants for input sources are determined.
Considering Spiritual Care for Religiously Involved LGBTQI Migrants and Refugees: A Tentative Map
Authors: Fensham Charles James
Published: December 2021

This paper describes research relevant to spiritual care for LGBTQI refugees and migrants. The literature indicates some distinct challenges faced by religiously involved LGBTQI migrants and refugees. LGBTQI migrants and refugees may not be able to experience family and religion as supportive compared to migrants and refugees who do not identify as LGBTQI. Such migrants and refugees thus face elevated levels of mental health challenges compared to non-LGBTQI refugees and they also face additional mental health risks compared to non-refugee LGBTQI adults and youth. Such risks include suicidality, depression, substance abuse, social isolation, internalised religious homonegativity, shame and risks to sexual health and a breakdown in the ability to trust others and caregivers. The paper identifies five seminal areas for extending care in the light of the research. These include building trust and properly assessing risk, working towards relational health, helping clients move to new ways of constructing and conceiving of family, easing the influence of internalised homonegativity and shame, and finding written and human resources that will be helpful to clients. These areas of care only present a tentative map as this issue requires more research and reflection.
Long-Term Lake Area Change and Its Relationship with Climate in the Endorheic Basins of the Tibetan Plateau
Authors: Wang Junxiao , Li Mengyao , Wang Liuming , She Jiangfeng , Zhu Liping , Li Xingong
Published: December 2021

Lakes are sensitive indicators of climate change in the Tibetan Plateau (TP), which have shown high temporal and spatial variability in recent decades. The driving forces for the change are still not entirely clear. This study examined the area change of the lakes greater than 1 km2 in the endorheic basins of the Tibetan Plateau (EBTP) using Landsat images from 1990 to 2019, and analysed the relationships between lake area and local and large-scale climate variables at different geographic scales. The results show that lake area in the EBTP has increased significantly from 1990 to 2019 at a rate of 432.52 km2·year−1. In the past 30 years, lake area changes in the EBTP have mainly been affected by local climate variables such as precipitation and temperature. At a large scale, Indian Summer Monsoon (ISM) has correlations with lake area in western sub-regions in the Inner Basin (IB). While Atlantic Multidecadal Oscillation (AMO) has a significant connection with lake area, the North Atlantic Oscillation (NAO) does not. We also found that abnormal drought (rainfall) brought by the El Niño/La Niña events are significantly correlated with the lake area change in most sub-regions in the IB.
Outbreak of Negative Narrow Bipolar Events in Two Mid-Latitude Thunderstorms Featuring Overshooting Tops
Authors: Liu Feifan , Zhu Baoyou , Lu Gaopeng , Ma Ming
Published: December 2021

Lightning discharges are the electrical production in thunderclouds. They radiate the bulk of radio signals in the very low-frequency and low-frequency (VLF/LF) that can be detected by ground-based receivers. One kind of special intra-cloud lightning discharges known as narrow bipolar events (NBEs) have been shown to be rare but closely linked to the convective activity that leads to hazardous weather. However, there is still lack of understanding on the meteorological conditions for thunderstorm-producing NBEs, especially for those of negative polarity, due to their rare occurrence. In this work, we aim to investigate what meteorological and electrical conditions of thunderclouds favor the production of negative NBEs. Combining with the VLF/LF radio signal measured by Jianghuai Area Sferic Array (JASA), S-band Doppler radar observation and balloon sounding data, two mid-latitude thunderstorms with outbreaks of negative NBEs at midnight in East China were analyzed. The comparison with the vertical radar profile shows that the bursts of negative NBEs occurred near thunderclouds with overshooting tops higher than 18 km. Manifestation of negative NBEs is observed with a relatively low spectrum width near thundercloud tops. Our findings suggest that the detection of negative NBEs would provide a unique electrical means to remotely probe overshooting tops with implications for the exchange of troposphere and stratosphere.
Enhanced Pre-STAP Beamforming for Range Ambiguous Clutter Separation with Vertical FDA Radar
Authors: Wang Weiwei , Wan Pengfei , Zhang Jun , Liu Zhixin , Xu Jingwei
Published: December 2021

Medium pulse repetition frequency (MPRF) is an important mode in airborne radar system. Since MPRF mode brings both Doppler and range ambiguities, it causes difficulty for the airborne radar to suppress ground or sea clutter. In recent years, it has been pointed out that the frequency diverse array (FDA) radar is capable of separating the range ambiguous clutter, which is helpful for the airborne radar in detecting weak moving targets originally buried in ambiguous clutter. To further improve the ambiguous clutter separation performance, an enhanced pre-STAP beamforming for range ambiguous clutter suppression is proposed for the vertical FDA planar array in this paper. With consideration of range dependence of the vertical spatial frequency, a series of pre-STAP beamformers are designed using a priori knowledge of platform and radar parameters. The notches of the beamformers are aligned with the ambiguous clutter to extract echoes from desired range region while suppressing clutter from ambiguous range regions. The notches can be widened by using covariance matrix tapering technique and the proposed method can improve the performance of range ambiguous clutter separation with limited degrees-of-freedom (DOFs). Simulation examples show the effectiveness of the proposed method.