bluuebunny/crossref_metadata_2025 huggingface dataset:
Incorporating Effect Factors into the Relationship between Biodiversity and Ecosystem Functioning (BEF)
Authors: Hou Jian , Feng Haobo , Wu Menghan
Published: April 2022

Generally, the high levels of biodiversity found in natural ecosystems have positive effects on ecosystem functions (EFs), though the intensity and direction of such effects can vary. This is associated with the impacts of other EF-driving factors. In this study, the factors that affect biodiversity-ecosystem functioning (BEF) are reviewed and summarized, and current gaps in the research on the effects of these factors on BEF are discussed. Moreover, a new conceptual model, the generating-presentation model, accounting for links between effect factors and EFs, is built to provide a systematic means of understanding how different factors affect BEF. The model shows that the correlation between biodiversity and EFs can be described as involving a cascade process, while the separation of biodiversity and EFs from ecosystems without considering integrated features is not appropriate for BEF-related research. The generating-presentation model can comprehensively reflect the effects of different factors on EFs and thus has major theoretical and applied implications.
An Evaluation of Choroidal and Retinal Nerve Fiber Layer Thicknesses Using SD-OCT in Children with Childhood IgA Vasculitis
Authors: Simsek Ali , Tekin Mehmet
Published: April 2022

Background: We aimed to evaluate choroidal and retinal nerve fiber layer (RNFL) thicknesses in children undergoing the childhood IgA vasculitis (IgAV). Methods: Fifty-two patients with IgAV aged 1–6 years and 54 healthy children were included. Cases’ age, sex, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), RNFL thicknesses, and choroidal thickness values were recorded. Results: Median foveal center choroidal thickness was 374.0 µm (315.0 to 452.0 µm) in the IgAV group and 349.5 µm (285.0 to 442.0 µm) in the control group (p = 0.001). Median average RNFL thickness was 110.0 µm (91.0 to 134.0 µm) in the IgAV group and 104.0 µm (89.0 to 117.0 µm) in the control group (p < 0.001). Choroidal and RNFL thicknesses were significantly greater in all quadrants in the IgAV group than in the control group. No correlation was determined between ESR or CRP and foveal center choroidal and average RNFL thicknesses. Conclusions: Our findings show that choroidal and RNFL thicknesses increased significantly in children undergoing childhood IgA vasculitis compared to the healthy control group. These findings show that the choroid and RNFL are also affected by the inflammatory process in IgAV, which is a systemic vasculitis. We think that the choroidal and RNFL thicknesses can be used as a biomarker for childhood IgAV.
Discriminating Bacterial Infection from Other Causes of Fever Using Body Temperature Entropy Analysis
Authors: Vargas Borja , Cuesta-Frau David , González-López Paula , Fernández-Cotarelo María-José , Vázquez-Gómez Óscar , Colás Ana , Varela Manuel
Published: April 2022

Body temperature is usually employed in clinical practice by strict binary thresholding, aiming to classify patients as having fever or not. In the last years, other approaches based on the continuous analysis of body temperature time series have emerged. These are not only based on absolute thresholds but also on patterns and temporal dynamics of these time series, thus providing promising tools for early diagnosis. The present study applies three time series entropy calculation methods (Slope Entropy, Approximate Entropy, and Sample Entropy) to body temperature records of patients with bacterial infections and other causes of fever in search of possible differences that could be exploited for automatic classification. In the comparative analysis, Slope Entropy proved to be a stable and robust method that could bring higher sensitivity to the realm of entropy tools applied in this context of clinical thermometry. This method was able to find statistically significant differences between the two classes analyzed in all experiments, with sensitivity and specificity above 70% in most cases.
Firefly Algorithm-Based Optimization of the Additional Energy Yield of Bifacial PV Modules
Authors: Fajuke Ibukun Damilola , Raji Atanda K.
Published: April 2022

A solar bifacial photovoltaic (PV) module is designed so that it permits the addition of the back electrode to the prevailing silicon PV on the front side. Hence, it has the ability to harvest energy using its front and back faces. This study presents an optimization model for calculating the extra energy yield (EY) that can be harvested from the backside of a bifacial PV module using the Firefly Algorithm (FA). Mathematical modelling of the various parameters that influence the extra EY of the backside of a bifacial module was carried out using SIMULINK. Moreover, the mathematical model of the EY of the module was also carried out and then optimized using FA. The optimization model was confined to two orientation states namely the vertical south–north and vertical east–west at Ogbomosho (8.1227° N, 4.2436° E), Nigeria, with different values of albedo and mounting heights. The simulation result shows that the vertical east–west oriented modules outperform the vertical south–north oriented modules in terms of the EY generated. The result also showed that the maximum value of the EY is harvested at a mounting height of 1 m above the ground with row spacing of 2.5 m and a tilt angle of 25 degrees. Therefore, an optimal selection of the mounting surface (albedo) and mounting elevation values can harvest an extra EY of 5 to 45 per cent and help minimize the cost of energy generated using bifacial PV modules for electricity generation.
Out-of-Step Prediction Using DQN-Based Disturbance Observer and Its RTDS Verification
Authors: Yang Sun Jick , Amare Nebiyeleul Daniel , Kim Jun Woo , Son Young Ik
Published: April 2022

Despite having extensive research dedicated towards designing methodologies for synchronous out-of-step detection, the risk posed by a large-scale power blackout still makes power system protection an active research area. In recent decades, multiple out-of-step detection techniques such as impedance-based relays and equal-area criterion-analysis-based methods have been widely adopted. However, these conventional techniques have been known to suffer from drawbacks that may be attributed to the inherent assumptions of their foundational design principles. Therefore, to alleviate some of the problems faced in the currently adopted techniques, researchers have been studying the implementation of estimation algorithms for synchronous out-of-step detection. Aiming to contribute to this research area, this paper proposes a synchronous out-of-step detection algorithm that uses a deep Q-network-based disturbance observer, robust to measurement noise. Using the disturbance estimation provided by the observer and a separately gathered critical clearing time data of the power grid, a neural network is trained to relate the magnitude of the estimation with the critical clearing time. The trained neural network is then used to provide an estimation of the critical clearing time for the algorithm, which uses the information to predict whether a fault will result in a stable power swing or a synchronous out-of-step detection. The performance of the proposed algorithm is verified through a real-time digital-simulator-based hardware-in-the-loop simulation. The results show that the proposed algorithm can detect synchronous out-of-step prediction by estimating the disturbance resulting from line fault within two cycles and predicting the critical clearing time at sample fault locations within a 3% margin of error.
Dielectric Response Model for Transformer Insulation Using Frequency Domain Spectroscopy and Vector Fitting
Authors: Hernandez Giovanni , Ramirez Abner
Published: April 2022

This paper proposes a rational approximation-based approach to find positive real parameters for the extended Debye model (EDM), aimed at condition assessment of insulation systems of power transformers. The EDM can model the slow and fast polarization phenomenon, including relaxation mechanisms with different relaxation times within a composite dielectric material. In the proposed approach, the complex permittivity of the transformer’s composite insulation is approximated via rational functions, as given by the vector fitting (VF) software tool, and the EDM parameters are identified from the obtained poles/residues. To guarantee positive real parameters, i.e., a physically realizable circuit, VF is internally modified to calculate the final residues of the rational approximation via a constrained linear least-squares problem without resorting to further post-processing algorithms, as in existing methods, hence without affecting fitting accuracy. The effectiveness of the parametrized EDM is demonstrated in two ways: (a) by reconstructing frequency domain spectroscopy (FDS) curves provided via measurements in new oil-immersed power transformers and (b) by the comparison of the calculated polarization current given by EDM versus real measurements in time domain. The achieved fitting accuracy in most of the cases is above 99 percent for the reconstructed FDS curves, while the polarization current waveform is reproduced with good agreement.
Recovery of Sewage Sludge in the Cement Industry
Authors: Rusănescu Carmen Otilia , Voicu Gheorghe , Paraschiv Gigel , Begea Mihaela , Purdea Larisa , Petre Ivona Camelia , Stoian Elena Valentina
Published: April 2022

This paper presents an analysis of the literature that studies the possibility of sewage sludge being used in the cement industry to reduce carbon dioxide emissions from cement production and thus solve the problem of disposing of sewage sludge so that it is no longer stored, avoiding soil pollution with heavy metals, and reducing pressure on the environment. The ash of sewage sludge is a good pozzolanic material, because when it is finely ground, it can be used as a partial substitute for Portland cement. This reduces waste storage costs. Sewage sludge ash was mixed with cement, and it was analyzed to determine whether the paste obtained could be used as a raw material in the cement industry. The presented results are on the hydration characteristics of the sewage sludge ash, the compressive strength of the cement determined after different days, the workability of the cement, and the porosity of the cement paste and the ash.
Momentum-Dependent Cosmic Ray Muon Computed Tomography Using a Fieldable Muon Spectrometer
Authors: Bae Junghyun , Chatzidakis Stylianos
Published: April 2022

Cosmic ray muon tomography has been recently explored as a non-destructive technique for monitoring or imaging dense well-shielded objects, classically not achievable with traditional tomographic methods. As a recent example of technology transition from high-energy physics to real-world engineering applications, cosmic ray muon tomography has been used with various levels of success in nuclear nonproliferation. However, present muon detection systems have no momentum measurement capabilities and recently developed muon-based radiographic techniques rely only on muon tracking. This unavoidably reduces resolution and requires longer measurement times thus limiting the widespread use of cosmic ray muon tomography. Measurement of cosmic ray muon momenta has the potential to significantly improve the efficiency and resolution of cosmic ray muon tomography. In this paper, we propose and explore the use of momentum-dependent cosmic ray muon tomography using multi-layer gas Cherenkov radiators, a new concept for measuring muon momentum in the field. The muon momentum measurements are coupled with a momentum-dependent imaging algorithm (mPoCA) and image reconstructions are presented to demonstrate the benefits of measuring momentum in cosmic ray muon tomography.
Sectoral Analysis of the Fundamental Criteria for the Evaluation of the Viability of Wave Energy Generation Facilities in Ports—Application of the Delphi Methodology
Authors: Cascajo Raúl , Molina Rafael , Pérez-Rojas Luís
Published: April 2022

Nearly 40% of the world’s population lives within 100 kilometres of the coast with the risk that this implies in terms of exposure to the effects of climate change. Ocean energy, according to the IPCC (Intergovernmental Panel on Climate Change) in 2019, has been identified as one of the measures for mitigating these effects. In addition, ocean energy can play an essential role in achieving some of the SDGs (Sustainable Development Goals) set at the Paris Climate Summit in 2015, namely SDG 7 (clean and affordable energy) and SDG 13 (climate action) and could have a substantial impact on others such as SDG 1 (poverty eradication), SDG 2 (end hunger), SDG 5 (gender equality), SDG 6 (universal energy access), SDG 8 (promote sustainable economic growth), SDG 9 (build resilient infrastructure), SDG 14 (sustainable conservation of oceans and seas) and SDG 17 (promote sustainable development cooperation). There are several projects under development around the world aimed at extracting energy from waves. However, to date, no technology has been found that, in general terms, is superior to others. There are several conditioning factors that prevent this type of energy from reaching the level of maturity of other marine renewable energies. These are mainly economic, technological, environmental, and regulatory, to mention the most important. This article aims to analyse the approaches that other researchers have adopted to evaluate wave energy projects and, through a prospective method of expert consultation such as the Delphi methodology, will present the most generally accepted criteria for successful wave energy projects. Subsequently, the validity of these results will be analysed for the case of the use of the energy produced for self-consumption in ports.
Climate Adaptation, Drought Susceptibility, and Genomic-Informed Predictions of Future Climate Refugia for the Australian Forest Tree Eucalyptus globulus
Authors: Butler Jakob B. , Harrison Peter A. , Vaillancourt René E. , Steane Dorothy A. , Tibbits Josquin F. G. , Potts Brad M.
Published: April 2022

Understanding the capacity of forest tree species to adapt to climate change is of increasing importance for managing forest genetic resources. Through a genomics approach, we modelled spatial variation in climate adaptation within the Australian temperate forest tree Eucalyptus globulus, identified putative climate drivers of this genomic variation, and predicted locations of future climate refugia and populations at-risk of future maladaptation. Using 812,158 SNPs across 130 individuals from 30 populations (i.e., localities) spanning the species’ natural range, a gradientForest algorithm found 1177 SNPs associated with locality variation in home-site climate (climate-SNPs), putatively linking them to climate adaptation. Very few climate-SNPs were associated with population-level variation in drought susceptibility, signalling the multi-faceted nature and complexity of climate adaptation. Redundancy analysis (RDA) showed 24% of the climate-SNP variation could be explained by annual precipitation, isothermality, and maximum temperature of the warmest month. Spatial predictions of the RDA climate vectors associated with climate-SNPs allowed mapping of genomically informed climate selective surfaces across the species’ range under contemporary and projected future climates. These surfaces suggest over 50% of the current distribution of E. globulus will be outside the modelled adaptive range by 2070 and at risk of climate maladaptation. Such surfaces present a new integrated approach for natural resource managers to capture adaptive genetic variation and plan translocations in the face of climate change.
Study on Comparisons of Bio-Hydrogen Yield Potential and Energy Conversion Efficiency between Stem and Leaf of Sweet Potato by Photo-Fermentation
Authors: Zhang Haorui , Lei Tingzhou , Lu Shijie , Zhu Shengnan , Li Yameng , Zhang Quanguo , Zhang Zhiping
Published: April 2022

The source of raw materials for hydrogen production can be expanded by using vine waste as a substrate. Likewise, the effectiveness of vine waste can also be improved. However, plant parts such as stems and leaves often differ in physicochemical properties, which significantly affects the effectiveness of biochemical transformation. In this research, sweet potato was used as substrate in photo-fermentative hydrogen production (PFHP) to evaluate differences in bio-hydrogen production yield potential and energy conversion efficiency for its stem and leaf. Physicochemical properties were determined using the following techniques: elementary analysis, SEM, and X-ray diffraction. The Gompertz model was adopted to analyze the kinetic parameters, and energy conversion efficiency was calculated. The results showed that stem samples with loose structures produced more hydrogen, with a total cellulose and hemicellulose content of 44.6%, but crystallinity was only 29.67%. Cumulative bio-hydrogen yield of stem was 66.03 mL/g TS, which was 3.59 times higher than that of leaf. An increase of 258.93% in energy conversion efficiency was obtained when stem was used for PFHP. In conclusion, stem samples were more suitable for PFHP than leaf samples.
Gene–Environment Interaction on Type 2 Diabetes Risk among Chinese Adults Born in Early 1960s
Authors: Song Chao , Gong Weiyan , Ding Caicui , Wang Rui , Fang Hongyun , Liu Ailing
Published: April 2022

Background: Gene–environment interactions on type 2 diabetes (T2D) risk are studied little among Chinese adults. Aim: This study aimed to explore the interactions among Chinese adults born in early 1960s. Methods: The interaction of single nucleotide polymorphisms (SNPs) and environmental factors on T2D risk were analyzed by multiple linear or logistic regression models, and in total 2216 subjects were included with the age of 49.7 ± 1.5 years. Results: High dietary intake increased the effects of rs340874 on impaired fasting glucose (IFG), rs5015480, rs7612463 on T2D (OR = 2.27, 2.37, 11.37, respectively), and reduced the effects of rs7172432 on IFG, rs459193 on impaired glucose tolerance (IGT) (OR = 0.08, 0.28, respectively). The associations between rs4607517 and T2D, rs10906115 and IGT, rs4607103, rs5015480 and IFG could be modified by drinking/smoking (OR = 2.28, 0.20, 3.27, 2.58, respectively). Physical activity (PA) interacted with rs12970134, rs2191349, rs4607517 on T2D (OR = 0.39, 3.50, 2.35, respectively), rs2796441 and rs4607517 on IGT (OR = 0.42, 0.33, respectively), and rs4430796, rs5215, and rs972283 on IFG (OR = 0.39, 3.05, 7.96, respectively). Significant interactions were identified between socioeconomic status and rs10830963, rs13266634 on T2D (OR = 0.41, 0.44, respectively), rs1470579 and rs2796441 on IGT (OR = 2.13, 2.37, respectively), and rs7202877 and rs7612463 on IFG (OR = 5.64, 9.18, respectively). Conclusion: There indeed existed interactions between environmental factors and genetic variants on T2D risk among Chinese adults.
Knowledge of Osteoporosis and Its Associated Factors among Public Health Professionals in a Municipal Office in Japan
Authors: Oba Shino , Kajiyama Naomi
Published: April 2022

Lifelong efforts to maintain bone health are beneficial for preventing osteoporosis, and public health professionals play an important role in that. The current study aimed to assess the knowledge of osteoporosis among public health professionals in a Japanese municipal office and explored associated factors. A questionnaire was distributed to 124 eligible public health professionals in a municipal office in S City, Japan; in total, 89 individuals who returned it were analyzed. Their knowledge of osteoporosis was assessed using the revised Osteoporosis Knowledge Test, its two subscales, and the Facts on Osteoporosis Quiz, translated into Japanese. To compare the level of knowledge between categories of selected factors, the Wilcoxon rank-sum test or the Kruskal–Wallis test was applied. The mean of correct answers ranged from 70 to 79%, depending on the scale. The knowledge level was significantly higher among registered dietitians than among public health nurses. Higher scores were significantly associated with past learning experience in off-the-job training, with having a family history of osteoporosis, and with having had a past osteoporosis test. Japanese public health professionals were likely to have moderate knowledge of osteoporosis. Several factors were implied to be associated with the knowledge level of osteoporosis.
Pharmacy Students’ Attitudes and Perceptions toward Financial Management Education
Authors: Adunlin Georges , Pan Kevin
Published: April 2022

(1) Background: Pharmacy-related financial management training and education are an integral part of the pharmacy curriculum. This study aims to evaluate pharmacy students’ perceptions toward financial management education, their attitudes on its clinical relevance, and their ability to use financial management knowledge in introductory and advanced pharmacy practice experiences. (2) Methods: An online survey was sent to third- and fourth-year pharmacy students. The survey assessed the following three themes: perceptions toward financial management education; attitudes toward the clinical relevance of financial management education; and the student’s ability to use knowledge of financial management in practice. Descriptive statistics were used to summarize the data. (3) Results: The overall response rate for the survey was 60% (139/233). Overall, the study showed a positive perception and attitude toward financial management education. Results indicate that pharmacy students were confident in their ability to use financial management knowledge in pharmacy practice. (4) Conclusions: This survey found an overall optimism in financial management education’s role in pharmacy practice and the ability to obtain financial management competencies in professional pharmacy training. With the evolving practice requirements, pharmacy schools should adapt their financial management curricula with relevant skills to prepare students to become effective entrepreneurs, innovators, and practice leaders.
What Is Genomic High-Risk Myeloma?
Authors: Davies Faith E. , Walker Brian A.
Published: April 2022

Although treatment of multiple myeloma has changed dramatically over time, there is still a subpopulation of patients who do not respond to treatments and are labeled as high risk. A combination of serum and genomic markers can be used to identify and stratify these patients according to associations with outcome. The most common method of identifying the genomic markers of high-risk multiple myeloma is using fluorescence in situ hybridization using probes to identify IgH translocations or copy number changes including the t(4;14), t(14;16), t(14;20), gain 1q, and del(17p). However, as research studies utilize newer technologies, such as whole genome sequencing, more high-risk factors are being identified including mutations of TP53, DIS3, BRAF, and complex structural events. Integration of comprehensive genomic studies into clinical trials will aid in defining the genomic high-risk landscape of multiple myeloma, which in turn can be transferred to individual patient diagnostics and treatment management.
Unique Presentation of Bortezomib-Associated Thrombotic Microangiopathy Responsive to Therapeutic Plasma Exchange and Eculizumab Therapy
Authors: Sterner Robert C. , Rose William Nicholas
Published: April 2022

Thrombotic microangiopathies (TMA) are a rare group of life-threatening hematological conditions characterized by thrombocytopenia and microangiopathic hemolytic anemia. Although our understanding of the pathophysiology and the availability of diagnostic testing has improved for primary TMAs, such as thrombotic thrombocytopenic purpura, the pathophysiology underlying secondary TMAs, including drug-induced TMAs (DITMAs), remains less clear. In this case report, we present the unique case of a patient with a history of multiple myeloma that presented four months after the initiation of bortezomib therapy with a bortezomib-associated TMA that responded to therapeutic plasma exchange (TPE) with plasma replacement and eculizumab therapy. This case demonstrates the possible utility of TPE with plasma replacement and eculizumab therapy in DITMA patients that fail to respond following a trial of holding the suspected medication.
Root-Zone Amendments of Biochar-Based Fertilizers: Yield Increases of White Cabbage in Temperate Climate
Authors: Grafmüller Jannis , Schmidt Hans-Peter , Kray Daniel , Hagemann Nikolas
Published: April 2022

The use of biochar is an important tool to improve soil fertility, reduce the negative environmental impacts of agriculture, and build up terrestrial carbon sinks. However, crop yield increases by biochar amendment were not shown consistently for fertile soils under temperate climate. Recent studies show that biochar is more likely to increase crop yields when applied in combination with nutrients to prepare biochar-based fertilizers. Here, we focused on the root-zone amendment of biochar combined with mineral fertilizers in a greenhouse trial with white cabbage (Brassica oleracea convar. Capitata var. Alba) cultivated in a nutrient-rich silt loam soil originating from the temperate climate zone (Bavaria, Germany). Biochar was applied at a low dosage (1.3 t ha−1). The biochar was placed either as a concentrated hotspot below the seedling or it was mixed into the soil in the root zone representing a mixture of biochar and soil in the planting basin. The nitrogen fertilizer (ammonium nitrate or urea) was either applied on the soil surface or loaded onto the biochar representing a nitrogen-enhanced biochar. On average, a 12% yield increase in dry cabbage heads was achieved with biochar plus fertilizer compared to the fertilized control without biochar. Most consistent positive yield responses were observed with a hotspot root-zone application of nitrogen-enhanced biochar, showing a maximum 21% dry cabbage-head yield increase. Belowground biomass and root-architecture suggested a decrease in the fine root content in these treatments compared to treatments without biochar and with soil-mixed biochar. We conclude that the hotspot amendment of a nitrogen-enhanced biochar in the root zone can optimize the growth of white cabbage by providing a nutrient depot in close proximity to the plant, enabling efficient nutrient supply. The amendment of low doses in the root zone of annual crops could become an economically interesting application option for biochar in the temperate climate zone.
Soil Water Balance and Shallow Aquifer Recharge in an Irrigated Pasture Field with Clay Soils in the Willamette Valley, Oregon, USA
Authors: Gómez Daniel G. , Ochoa Carlos G. , Godwin Derek , Tomasek Abigail A. , Zamora Re María I.
Published: April 2022

Quantifying soil water budget components, and characterizing groundwater recharge from irrigation seepage, is important for effective water resources management. This is particularly true in agricultural fields overlying shallow aquifers, like those found in the Willamette Valley in western Oregon, USA. The objectives of this two-year study were to (1) determine deep percolation in an irrigated pasture field with clay soils, and (2) assess shallow aquifer recharge during the irrigation season. Soil water and groundwater levels were measured at four monitoring stations distributed across the experimental field. A water balance approach was used to quantify the portioning of different water budget components, including deep percolation. On average for the four monitoring stations, total irrigation applied was 249 mm in 2020 and 381 mm in 2021. Mean crop-evapotranspiration accounted for 18% of the total irrigation applied in 2020, and 26% in 2021. The fraction of deep percolation to irrigation was 28% in 2020 and 29% in 2021. The Water Table Fluctuation Method (WTFM) was used to calculate shallow aquifer recharge in response to deep percolation inputs. Mean aquifer recharge was 132 mm in 2020 and 290 mm in 2021. Antecedent soil water content was an important factor influencing deep percolation. Study results provided essential information to better understand the mechanisms of water transport through the vadose zone and into shallow aquifers in agricultural fields with fine-textured soils in the Pacific Northwest region in the USA.
Perceived Supervisor Support for Health Affects Presenteeism: A Cross-Sectional Study
Authors: Mori Takahiro , Nagata Tomohisa , Nagata Masako , Odagami Kiminori , Mori Koji
Published: April 2022

We investigated the relationship between perceived supervisor support for health (PSSH) and presenteeism by adjusting for psychological distress and employee work engagement. These are the mediators of the two paths shown in the job demands-resources model. A cross-sectional study was conducted using a questionnaire survey among 15,158 non-managerial employees from seven companies in Japan considered to have relatively high perceived organizational support for health (POSH). PSSH was evaluated with a single question, “My supervisor supports employees to work vigorously and live a healthy life”, on a four-point scale. Presenteeism was estimated using the quantity and quality method. Multilevel logistic regression analyses nested by company were conducted. Lower PSSH was more likely to be associated with presenteeism, but after adjusting for psychological distress evaluated by K6 and for work engagement, the relationship between PSSH and presenteeism weakened. Our results suggested that lower PSSH is linked to presenteeism through both psychological states because of its role as a resource, and other independent factors, even with relatively high POSH. Increased PSSH could act as a measure against presenteeism in the workplace. To achieve this, it is important to create an environment where supervisors can easily encourage employees to improve their health.
A Qualitative Study Exploring the Barriers and Facilitators for Maintaining Oral Health and Using Dental Service in People with Severe Mental Illness: Perspectives from Service Users and Service Providers
Authors: Mishu Masuma Pervin , Faisal Mehreen Riaz , Macnamara Alexandra , Sabbah Wael , Peckham Emily , Newbronner Liz , Gilbody Simon , Gega Lina
Published: April 2022

People with severe mental illness suffer from a high burden of oral diseases, which can negatively impact their physical and mental well-being. Despite the high burden, they are less likely to engage in oral health care including accessing dental services. We aimed to identify both the service users’ and service providers’ perspective on the barriers and facilitators for maintaining oral health and dental service use in people with severe mental illness. Qualitative exploration was undertaken using dyadic or one-to-one in-depth interviews with service users in the UK with a diagnosis of schizophrenia, schizoaffective disorder or bipolar disorder. Service providers, including mental health and dental health professionals, and informal carers (people identified as family or friend who are not paid carers) were also interviewed. Thematic analysis of the data revealed three main cross-cutting themes at the personal, inter-personal and systems level: amelioration of the problem, using a tailored approach and provision of comprehensive support. The main barriers identified were impact of mental ill-health, lack of patient involvement and tailored approach, and accessibility and availability of dental services including lack of integration of services. The main facilitators identified were service providers’ effective communication skills and further support through the involvement of carers. The findings suggest that the integration of dental and mental health services to provide tailored support for overall health and well-being, including the oral health of the patient, can better support people with severe mental illness regarding their oral health needs.
The Significance of Angling in Stress Reduction during the COVID-19 Pandemic—Environmental and Socio-Economic Implications
Authors: Karpiński Emil Andrzej , Skrzypczak Andrzej Robert
Published: April 2022

Recreational fishing and other outdoor recreational activities have been proven to have positive effects on mental health, including neutralizing pandemic stress. This study aims to identify the perceptions and behavior of recreational anglers during the COVID-19 pandemic along with identifying the factors that determine attitudes. This study is essential for understanding the complex economic, social, and environmental implications associated with a pandemic. Perceptions of pandemic stress reduction were confirmed by 63.8% of anglers, and nearly 98% felt there was no risk of infection from fishing. These feelings were most strongly positively associated and explained by a preference for fishing with friends and family and the frequency of fishing. Over 26% of respondents fished more frequently during the pandemic. Additional free time and the need to escape the pandemic media hype were the main factors for the increase in angler activity. The balance of benefits from changes in angler pandemic behavior was ambiguous. This was determined by considering the potential increase in pressure on the environmental resources that anglers use. Given the positive effects of angling on stress reduction, it is not advisable for policymakers to restrict recreational fishing access. Instead, best management practices should reduce sanitary bottlenecks to increase safety on fishing grounds.
A Scoping Review of Galectin-3 as a Biomarker of Cardiovascular Diseases in Pediatric Populations
Authors: Smereczyńska-Wierzbicka Ewa , Pietrzak Radosław , Werner Bożena
Published: April 2022

Galectin-3 as a cardiac biomarker has proven to be a significant prognostic tool in adults. However, it has not yet been established in the pediatric population as a biomarker in daily clinical practice. The aim of the study was to summarize the current knowledge on galectin-3 as a biomarker in children with cardiac conditions by reviewing the literature. Bibliographic databases such as PubMed, Web of Science and Embase were searched, and consequently twelve articles met the inclusion criteria. Supplemental handsearching of references delivered one additional source. These prospective studies concerning galectin-3 as a cardiac biomarker present analyses performed in cohorts composed of healthy children and children with cardiovascular diseases. The results, despite being based on small cohort studies, inform that galectin-3 could serve as a potential biomarker in cardiovascular risk stratification in children with heart failure, arrhythmia, Kawasaki disease or in patients undergoing cardiac surgery. The evidence for the usefulness of galectin-3 in the assessment of such pathologies as idiopathic dilated cardiomyopathy, coarctation of the aorta, functionally univentricular heart or tetralogy of Fallot were not completely confirmed. Galectin-3 seems to be a promising biomarker; however, there is a need for further research to establish its use in daily clinical practice.
Between and Within-Country Variations in Infant and Young Child Feeding Practices in South Asia
Authors: Tariqujjaman Md. , Hasan Md. Mehedi , Mahfuz Mustafa , Ahmed Tahmeed , Hossain Muttaquina
Published: April 2022

This study aimed to explore variations in Infant and Young Child Feeding (IYCF) practices between different South Asian Countries (SACs) and within their sociodemographic characteristics including place of residence, mother age, mother education, child sex, and wealth quintiles within the SACs. We extracted 0–23 months age children’s data from the nationally representative survey of Afghanistan, Bangladesh, India, Maldives, Nepal, and Pakistan. Among all SACs, the early initiation of breastfeeding (EIBF) practice was 45.4% with the highest prevalence in the Maldives (68.2%) and the lowest prevalence in Pakistan (20.8%). Exclusive breastfeeding (EBF) practice was 53.9% with the highest prevalence in Nepal (67%) and the lowest prevalence in Afghanistan (42%). Only 13% of children had a minimum acceptable diet (MAD), with the highest prevalence in the Maldives (52%) and the lowest prevalence in India (11%). We found higher IYCF practices among the mothers with secondary or higher levels of education (EIBF: 47.0% vs. 43.6%; EBF: 55.5% vs. 52.0%; MAD: 15.3% vs. 10.0%), urban mothers (MAD: 15.6% vs. 11.8%), and mothers from the richest households (MAD: 17.6% vs. 8.6%) compared to the mothers with no formal education or below secondary level education, rural mothers and mothers from the poorest households, respectively. Mothers from the poorest households had better EIBF, EBF, and continued breastfeeding at 1-year (CBF) practices compared to the mothers from the richest households (EIBF: 44.2% vs. 40.7%; EBF: 54.8% vs. 53.0%; CBF: 86.3% vs. 77.8%). Poor IYCF practices were most prevalent in Afghanistan, Pakistan, and India.
The Influence of Perceived Red Tape on Public Employees’ Procrastination: The Conservation of Resource Theory Perspective
Authors: Huang Qiufeng , Zhang Kaili , Bodla Ali Ahmad , Wang Yanqun
Published: April 2022

Procrastination is a prevalent phenomenon in organizations, yet limited knowledge is available on how situational antecedents influence it. Based on the conservation of resource theory, we explore how and when perceived red tape influences public sector employees’ procrastination behavior. Using survey data of 751 public sector employees from China, we revealed that perceived red tape is positively associated with procrastination behavior, and role overload partially mediates the relationship between perceived red tape and procrastination behavior. Employees’ perceived overqualification augments the relationship between role overload and procrastination. Further, the moderated mediation model test illuminates that the indirect effect of perceived red tape on procrastination through role overload depends on perceived overqualification, which means that higher perceived overqualification amplifies the indirect effect. Our research enriches the literature on public sector employees’ procrastination behavior.
A Novel Ex Vivo Approach Based on Proteomics and Biomarkers to Evaluate the Effects of Chrysene, MEHP, and PBDE-47 on Loggerhead Sea Turtles (Caretta caretta)
Authors: Bianchi Laura , Casini Silvia , Vantaggiato Lorenza , Di Noi Agata , Carleo Alfonso , Shaba Enxhi , Armini Alessandro , Bellucci Francesco , Furii Giovanni , Bini Luca , Caliani Ilaria
Published: April 2022

The principal aim of the present study was to develop and apply novel ex vivo tests as an alternative to cell cultures able to evaluate the possible effects of emerging and legacy contaminants in Caretta caretta. To this end, we performed ex vivo experiments on non-invasively collected whole-blood and skin-biopsy slices treated with chrysene, MEHP, or PBDE-47. Blood samples were tested by oxidative stress (TAS), immune system (respiratory burst, lysozyme, and complement system), and genotoxicity (ENA assay) biomarkers, and genotoxic and immune system effects were observed. Skin slices were analyzed by applying a 2D-PAGE/MS proteomic approach, and specific contaminant signatures were delineated on the skin proteomic profile. These reflect biochemical effects induced by each treatment and allowed to identify glutathione S-transferase P, peptidyl-prolyl cis-trans isomerase A, mimecan, and protein S100-A6 as potential biomarkers of the health-threatening impact the texted toxicants have on C. caretta. Obtained results confirm the suitability of the ex vivo system and indicate the potential risk the loggerhead sea turtle is undergoing in the natural environment. In conclusion, this work proved the relevance that the applied ex vivo models may have in testing the toxicity of other compounds and mixtures and in biomarker discovery.
Effect of Chemotherapy Cytarabine and Acute Myeloid Leukemia on the Development of Spermatogenesis at the Adult Age of Immature Treated Mice
Authors: Khaleel Bara’ah , Lunenfeld Eitan , Kapelushnik Joseph , Huleihel Mahmoud
Published: April 2022

Acute myeloid leukemia (AML) accounts for around 20% of diagnosed childhood leukemia. Cytarabine (CYT) is involved in the AML treatment regimen. AML and CYT showed impairment in spermatogenesis in human and rodents in adulthood. We successfully developed an AML disease model in sexually immature mice. Monocytes and granulocytes were examined in all groups: untreated control, AML alone, CYT alone and AML+CYT (in combination). There was a significant increase in the counts of monocytes and granulocytes in the AML-treated immature mice (AML) compared to the control, and AML cells were demonstrated in the blood vessels of the testes. AML alone and CYT alone impaired the development of spermatogenesis at the adult age of the AML-treated immature mice. The damage was clear in the structure/histology of their seminiferous tubules, and an increase in the apoptotic cells of the seminiferous tubules was demonstrated. Our results demonstrated a significant decrease in the meiotic/post-meiotic cells compared to the control. However, CYT alone (but not AML) significantly increased the count of spermatogonial cells (premeiotic cells) that positively stained with SALL4 and PLZF per tubule compared to the control. Furthermore, AML significantly increased the count of proliferating spermatogonial cells that positively stained with PCNA in the seminiferous tubules compared to the control, whereas CYT significantly decreased the count compared to the control. Our result showed that AML and CYT affected the microenvironment/niche of the germ cells. AML significantly decreased the levels growth factors, such as SCF, GDNF and MCSF) compared to control, whereas CYT significantly increased the levels of MCSF and GDNF compared to control. In addition, AML significantly increased the RNA expression levels of testicular IL-6 (a proinflammatory cytokine), whereas CYT significantly decreased testicular IL-6 levels compared to the control group. Furthermore, AML alone and CYT alone significantly decreased RNA expression levels of testicular IL-10 (anti-inflammatory cytokine) compared to the control group. Our results demonstrate that pediatric AML disease with or without CYT treatment impairs spermatogenesis at adult age (the impairment was more pronounced in AML+CYT) compared to control. Thus, we suggest that special care should be considered for children with AML who are treated with a CYT regimen regarding their future fertility at adult age.
Ionizing Radiation Induces Disc Annulus Fibrosus Senescence and Matrix Catabolism via MMP-Mediated Pathways
Authors: Zhong Jiongbiao , Chen Joseph , Oyekan Anthony A. , Epperly Michael W. , Greenberger Joel S. , Lee Joon Y. , Sowa Gwendolyn A. , Vo Nam V.
Published: April 2022

Previous research has identified an association between external radiation and disc degeneration, but the mechanism was poorly understood. This study explores the effects of ionizing radiation (IR) on inducing cellular senescence of annulus fibrosus (AF) in cell culture and in an in vivo mouse model. Exposure of AF cell culture to 10–15 Gy IR for 5 min followed by 5 days of culture incubation resulted in almost complete senescence induction as evidenced by SA-βgal positive staining of cells and elevated mRNA expression of the p16 and p21 senescent markers. IR-induced senescent AF cells exhibited increased matrix catabolism, including elevated matrix metalloproteinase (MMP)-1 and -3 protein expression and aggrecanolysis. Analogous results were seen with whole body IR-exposed mice, demonstrating that genotoxic stress also drives disc cellular senescence and matrix catabolism in vivo. These results have important clinical implications in the potential adverse effects of ionizing radiation on spinal health.
Anti-Obesity and Anti-Hyperglycemic Effects of Meretrix lusoria Protamex Hydrolysate in ob/ob Mice
Authors: Kim Min Ju , Chilakala Ramakrishna , Jo Hee Geun , Lee Seung-Jae , Lee Dong-Sung , Cheong Sun Hee
Published: April 2022

Meretrix lusoria (M. lusoria) is an economically important shellfish which is widely distributed in South Eastern Asia that contains bioactive peptides, proteins, and enzymes. In the present study, the extracted meat content of M. lusoria was enzymatic hydrolyzed using four different commercial proteases (neutrase, protamex, alcalase, and flavourzyme). Among the enzymatic hydrolysates, M. lusoria protamex hydrolysate (MLPH) fraction with MW ≤ 1 kDa exhibited the highest free radical scavenging ability. The MLPH fraction was further purified and an amino acid sequence (KDLEL, 617.35 Da) was identified by LC-MS/MS analysis. The purpose of this study was to investigate the anti-obesity and anti-hyperglycemic effects of MLPH containing antioxidant peptides using ob/ob mice. Treatment with MLPH for 6 weeks reduced body and organ weight and ameliorated the effects of hepatic steatosis and epididymal fat, including a constructive effect on hepatic and serum marker parameters. Moreover, hepatic antioxidant enzyme activities were upregulated and impaired glucose tolerance was improved in obese control mice. In addition, MLPH treatment markedly suppressed mRNA expression related to lipogenesis and hyperglycemia through activation of AMPK phosphorylation. These findings suggest that MLPH has anti-obesity and anti-hyperglycemic potential and could be effectively applied as a functional food ingredient or pharmaceutical.
Candidate Genes and Pathways in Rice Co-Responding to Drought and Salt Identified by gcHap Network
Authors: Hao Zhiqi , Ma Sai , Liang Lunping , Feng Ting , Xiong Mengyuan , Lian Shangshu , Zhu Jingyan , Chen Yanjun , Meng Lijun , Li Min
Published: April 2022

Drought and salinity stresses are significant abiotic factors that limit rice yield. Exploring the co-response mechanism to drought and salt stress will be conducive to future rice breeding. A total of 1748 drought and salt co-responsive genes were screened, most of which are enriched in plant hormone signal transduction, protein processing in the endoplasmic reticulum, and the MAPK signaling pathways. We performed gene-coding sequence haplotype (gcHap) network analysis on nine important genes out of the total amount, which showed significant differences between the Xian/indica and Geng/japonica population. These genes were combined with related pathways, resulting in an interesting mechanistic draft called the ‘gcHap-network pathway’. Meanwhile, we collected a lot of drought and salt breeding varieties, especially the introgression lines (ILs) with HHZ as the parent, which contained the above-mentioned nine genes. This might imply that these ILs have the potential to improve the tolerance to drought and salt. In this paper, we focus on the relationship of drought and salt co-response gene gcHaps and their related pathways using a novel angle. The haplotype network will be helpful to explore the desired haplotypes that can be implemented in haplotype-based breeding programs.