bluuebunny/crossref_metadata_2025 huggingface dataset:
Sonhos e desejos da infância Guarani do Pico do Jaraguá, São Paulo
Authors: Maia Lima Antonio Henrique , De Mello Motta Aline Villela
Published: March 2017

A partir do convívio (etnográfico) com crianças nascidas no Tekoa Pyau, aldeia Guarani, próximo ao Parque Estadual do Pico do Jaraguá, em São Paulo, capital, surgiu a necessidade de conhecê-las melhor e pedir-lhes que contassem seu sonhos na forma de desenhos livres. A partir desses desenhos e das músicas discutimos desejos, tradição, desenvolvimento e futuro procurando responder à questão “o que desejam para seu futuro os Guarani-Mbya do Pico do Jaraguá, dado o contexto social e político em que estão inseridos, dentro da metrópole?”.
Feria del Cerrado, Goiânia: la participación social para el desarollo local
Authors: Tuma Raquel Lage , Marques Heitor Romero , Soares Maria Elisabeth Alves Mesquita
Published: March 2017

En esta investigación, se tuvo como propósito el análisis de la ‘Feria del Cerrado’ (Feira do Cerrado), como un instrumento de desarrollo local con la participación social de los artesanos. El objetivo ha sido indicar como una feria de artesanía puede contribuir para el desarrollo local, por medio de un grupo de artesanos. El procedimiento metodológico fue la investigación exploratoria, con revisión bibliográfica, en las áreas de desarrollo local sustentable, participación social y un estudio de caso sobre la ‘Feria del Cerrado’ (Feira do Cerrado), una feria de artesanías, situada en el municipio de Goiânia, Brasil. Se utilizó la técnica del estudio descriptivo e investigación de campo con entrevista semi estructurada aplicada a los dirigentes y feriantes, así como la observación de la feria y conversas informales con los feriantes, con la intención de identificar la situación real y proceder a un análisis de cómo ha sido la relación entre dirigentes y feriantes. A continuación es dado el enfoque a las  actividades de artesanías y el objeto de estudio de la ‘Feria del Cerrado’ (Feira do Cerrado), con la expectativa de que el desarrollo local sea facilitador de mejoría de la calidad de vida de grupos específicos.
Uso da análise envoltória de dados para mensuração da sustentabilidade de hotéis-fazenda em Pernambuco
Authors: Souza Viviane , Melo Andre de Souza , Sobral Marcos Felipe Falcão , Marília Valença Marília
Published: March 2017

O presente artigo fala da eficiência na gestão da responsabilidade socioambiental nos hotéis-fazenda da Região Agreste de Pernambuco. O universo da amostra são seis hotéis-fazenda que possuem algum apelo referente à sustentabilidade em seus sites. A pesquisa caracteriza-se como exploratória, descritiva e de corte transversal. A natureza dos dados é quantitativa usando uma metodologia não paramétrica conhecida como a Análise Envoltória de Dados (DEA).  Os resultados apresentam diferenças em relação à eficiência sustentável dos hotéis em análise. Entretanto há modificação de cenário quando se alteram as variáveis (inputs e outputs) da avaliação geral, alterando a eficiência relativa das unidades. A metodologia utilizada e os resultados podem orientar a aplicação dessa pesquisa em outras realidades.
Caracterização da Colônia de Pescadores Z2 de Cáceres em Mato Grosso
Authors: Façanha Cristiane Lima , Da Silva Carolina Joana
Published: March 2017

Esta pesquisa foi realizada na Colônia de pescadores Z2, em Mato Grosso, com o objetivo de caracterizá-la por meio de pesquisa documental. A Colônia é composta por 692 pescadores, com idade entre 30 e 60 anos e tempo de pesca de menos de 10 anos. A análise evidenciou a crescente participação das mulheres atuando como pescadoras e gestoras administrativas da Colônia. A base de dados apresentou-se como um recurso para subsidiar os pescadores nas demandas de sua inclusão em políticas públicas.
Análise dos determinantes do nível de felicidade subjetiva: uma abordagem local
Authors: Recena Aydos Leonardo , Figueiredo Neto Leonardo Francisco , Machado Teixeira Wladimir
Published: March 2017

A Economia da Felicidade é uma área interdisciplinar envolvendo psicologia, sociologia, economia, entre outras. O presente estudo buscou analisar determinantes econômicos e sociais que explicam os níveis de felicidade da população estudada. Um questionário no estilo survey foi aplicado a 600 indivíduos do município de Campo Grande, MS. Um modelo econométrico multinomial não linear apontou que a escolaridade, a idade, o estado civil e o Estado de origem são variáveis que influenciam nos níveis de felicidade.
Estratégias de Enfrentamento do Câncer Adotadas por Familiares de Indivíduos em Tratamento Oncológico
Authors: Mattos Karine , Blomer Thatiane Hilman , Brunatto Falchetti Campos Ana Carolina , Silvério Maria Regina
Published: March 2017

Trata-se este de um estudo de abordagem qualitativa, do tipo estudo de caso, com o objetivo de avaliar as estratégias de enfrentamento adotadas por familiares de indivíduos em tratamento oncológico. Participaram da pesquisa dez familiares de pacientes atendidos no serviço de oncologia do Hospital Nossa Senhora da Conceição, Tubarão, Santa Catarina, Brasil. Os resultados revelaram que, em sua maioria, a convivência tem sido uma experiência difícil e dolorosa. Quanto às estratégias de enfrentamento adotadas, o estudo demonstrou que procuram realizar atividades que evitem focalização na doença; utilizam drogas lícitas; e buscam suporte familiar ou religioso. Dessa forma, evidencia-se a necessidade de os profissionais da saúde prestarem suporte aos familiares, visto que estes se tornam fragilizados pelas mudanças desencadeadas no processo de adoecimento.
As Estratégias de Coping na Promoção à Saúde Mental de Pacientes Oncológicos: Uma Revisão Bibliográfica
Authors: Pereira Thayanne Branches , Rodrigues Branco Vera Lúcia
Published: March 2017

Embora os avanços da medicina tenham possibilitado a descoberta de formas de tratamento mais eficazes da doença do foro oncológico, o câncer continua a ser uma das doenças mais preocupantes para a comunidade científica e sociedade em geral. Desse modo, a respectiva pesquisa com base em referenciais bibliográficos, teve por objetivo geral investigar a utilização de estratégias de coping por pacientes oncológicos e os possíveis benefícios para seu quadro emocional. Em específico, situações de doença como o câncer, as estratégias de coping podem ser utilizadas tanto pelo paciente, quanto pelos familiares, uma vez que o processo de adoecimento tem características estressantes para os personagens envolvidos, desde a suspeita diagnóstica da doença até as etapas da reabilitação e reajuste psíquico do paciente, de forma a requerer esforços de enfrentamento da situação, sendo a tarefa primordial reconquistar o equilíbrio psíquico apropriado, para auxílio na evolução clínica e psicossocial do portador de câncer.
Trabalho em Saúde Mental e Estresse na Equipe: Questões para a Política Nacional de Humanização/SUS
Authors: Bellenzani Renata , Paro Daniela Megliorini , De Oliveira Marina Cardoso
Published: March 2017

Um dos focos da Política Nacional de Humanização (PNH) é promover saúde e bem-estar dos profissionais do SUS; a literatura aponta sua vulnerabilidade ao estresse ocupacional. Um estudo quali-quanti (observações etnográficas e aplicação da Escala de Estresse no Trabalho - 13 respondentes) investigou o estresse na equipe de um CAPS e suas práticas/processos de trabalho. Diagnosticou-se “nível intermediário de estresse” na equipe (M=2,5); 09 de 23 fatores psicossociais tiveram médias acima de 2,5 (altamente estressores). As mais altas: deficiência nas capacitações (M=3,8) e na circulação das informações (M=3,2); discriminação/favoritismo na instituição (M=3,2). A análise qualitativa, construcionista social, elucidou processos psicossociais e sentidos, “por trás” dos fatores objetivos, construídos sobre a assistência, a instituição e seus problemas. Destacam-se: sensações de despreparo técnico, tensões interpessoais, dificuldades comunicacionais e de lidar com a “loucura”. O estresse elevado sugere possível “desumanização” dos/ nos processos de trabalho do serviço e na sua relação com a gestão.
Waist Circumference as The Strongest Factor Related to Blood Glucose Level
Authors: Septyaningrum Nenni , Martini Santi
Published: March 2017

ABSTRACTThe increasing prevalence of overweight and obesity is associated with the increasing incident of type 2 diabetes mellitus. Obesity, especially abdominal obesity is an important risk factor for the onset of diabetes. The objective of this study was to determine the relationship between body mass index, waist circumference and waist hip ratio with blood glucose level. The study design was cross-sectional. The study population was elderly posyandu member aged 45 to 70 years in Menur clinic work area who were registered in elderly posyandu activities in May 2013. The numbers of sample were 60 respondents who drawn by simple random sampling method. The variabels of this study were the characteristics of respondent, body mass index, waist  circumference,  waist hip ratio and fasting blood glucose level. The study showed that respondents classified as overweight (38%), obesity (33, 3%), abdominal obesity based on waist circumference  (77.8%), abdominal obesity based on waist hip ratio (81,7 %) and blood glucose level more than 125 mg/dl (8.3%). Pearson correlation test showed that there was relationship between body mass index with blood sugar levels (p=0,007; r=0,345), between waist circumference with blood sugar levels (p=0,001; r=0,424) and  between waist hip ratio with blood sugar levels (p =0,002; r=0,392). Waist circumference as the strongest factor related to blood glucose level. Waist circumference measurement should be done in elderly posyandu activities to detect high-risk individuals with diabetes. Keywords: Diabetes, body mass index, waist circumference, waist hip ratio,                     blood glucose level
Accuracy of Measles Immunization Records and Reporting in Maternal and Child Health Card and Cohort Book
Authors: Finazis Rekha
Published: March 2017

ABSTRACTInfectious diseases such as diseases that can be prevented by immunization remains a problem in Indonesia, one of which is measles. The government has sought to prevent through measles immunization in infants aged 9 months. Seeing the efforts that have been made through measles immunization program and still finding measles in the community, it is necessary to evaluate the success of programs related to the measles immunization. This study was conducted to determine the problems that occur in terms of recording and reporting of data related to measles immunization in particular measles immunization data quality. The population was 5 posyandu with the highest number of children under five in the region of new health centers Gunung Anyar city of Surabaya. The number of respondents is as much as 50 respondents with details of each neighborhood health center will take 10 respondents. The sample selection is done through a rapid survey method. The variables studied were the quality of immunization data on books maternal and child health card or other health records compared with immunization data on a cohort book. Other variables are the quality of data on infants in posyandu regiter book by book cohort. The results showed that the percentage of the suitability of the data of measles in the community with book five cohort remains low in the neighborhood health center. Meanwhile, the percentage of suitability daata on the register books with babies in posyandu cohort book is also fairly low. This suggests that the quality of data recorded measles immunization is relatively low.Keywords: immunization, measles,infant recording, reporting
Environment Biological and Health Care Efforts Influenced of Lymfatic Filariasis Incidence, Sarmi Distric
Authors: Sipayung Mina , Wahjuni Chatarina Umbul , Devy Shrimarti
Published: March 2017

ABSTRACTDistrict Sarmi is the most endemic area of filariasis in Papua which has rate of microfilaria (mf) (47.06%) up to the year2012. In the Province Papua filarial worm is Wuchereria bancrofti and is transmitted through the bite of a mosquito vectors. Lymphatic filariasis does not cause death, but in chronic cases it causes disability, psychosocial problems, stigma, and decreased productivity. This study was aimed to analyze environment biological and health care efforts that influence the incidence of lymphatic filariasis. This study used case-control method. Samples comprised 32 case samples (mf +) and 32 control samples (mf-). Primary data were collected through interviews and observation. Data were analyzed using Chi-Square and continued with multivariate Logistic Regression. Statistical analysis obtained indicated two variables on the incidence of lymphatic filariasis limfatik in District Sarmi (health care efforts pvalue = 0.002, OR: 7.779, as well as the biological environment pvalue= 0.008, OR: 5.841). Significant variables were health services with sub-variables promotion, prevention and the environmental biology. Suggestion: Mosquito bites should be avoided, the vector should be controlled through mutual cooperation and health promotion should be implemented.Keywords: Wuchereria bancrofti, lymphatic filariasis, vector, health care,                         Sarmi Distric
Relationship Between TB Treatment Phase and Knowledge of MDR TB with TB Patient’s Compliance
Authors: Yuni I Dewa Ayu Made Made
Published: March 2017

Indonesia is in second rank of pulmonary TB cases in the world after India. Forty-six percent total cases in the world are accounted from India, Indonesia and China. It is estimated that 3,3% of new cases is multidrug-resistant tuberculosis (MDR TB), a level that has remained unchanged in recent years. Pulmonary tuberculosis is a cronic infectious disease. Long-time treatment with the amount of medication and variying treatment effects causes sufferers often treatened to drop out treatment during recovery. This research was aimed to analyze relationship between treatment phase and knowledge of MDR TB with TB patient compliance in the treatment. The method was used an observational analitic study with cross sectional design. The questionnaire was conducted on 59 patients TB. Sampling method is simple random sampling. Questionnaire were conducted to obtain more in-depth information about the variables studied. The research variable include patient characteristics (age, gender, education, occupation), treatment phase, knowledge of MDR TB and TBpatient compliance in the treatment. Based on Chi Square test, there was signifi cant relationship between TB treatment phase with TB patient compliance (p = 0.03;PR =1.593). There was relationship between knowledge of MDR TB patient with TB patient compliance (p = 0.039;PR = 1.164). The conclusion is that there was relationship between TB treatment phase and knowledge of MDR TB patient with TB patient compliance in the treatment. Knowledge of MDR TB enable the patient to understand that the disease can be cured with regular medical treatment as instructed.Keywords: treatment phase, knowledge of MDR TB, patient compliance
Risk Factors Correlated with Incidence of Low Birth Weight Cases
Authors: Purwanto Anjas Dwi
Published: March 2017

The infant with Low Birth Weight (LBW) was one of the risk factors that contributed to the high infant mortality, especially in the neonatal period. About 17% from 25 millions birth each year in the world are infant with LBW. LBW could be caused by multifactor that were maternal factors (maternal age, birth interval, parity, anemia), social-economic and behaviour, fetus factor, placental factor, and environmental factor. The research aims was to analyze the risk factors correlated with incidence of LBW. This research was an observational  research with case-control design. The number of samples in this research were 120 mothers who delivered in working area of RSIA Kendangsari in 2014. The subjects were selected used systematic random method. The independent variabels in this research were maternal age, education level, employment status, birth interval, parity, age pregnancy, multiple pregnancy, hypertension, and anemia, while the dependent variable in this research was LBW. Based on correlation analysis used Chi-square test showed there were not significant correlation (p>0,05) between birth interval and parity with LBW cases and there were significant correlations (p<0,05) between age pregnancy, hypertension during pregnancy and anemia with LBW cases. Odds Ratio (OR) were 13,571 on age pregnancy, 2,224 on multiple pregnancy,2,753 on hypertension and 4,030 on anemia. The conlusion showed that the risk factors of LBW cases were age pregnancy, multiple pregnancy, hypertension and anemia. While maternal age, education level, employment status, birth intervaland parity were not had any correlation with LBW cases.Keywords: LBW, risk factors, babies, maternal, pregnancy
Analysis and Application of a Novel Layered Bidirectional Equalizer for Series Connected Battery Strings
Authors: Wang Shubiao , Kang Longyun , Li Wenbiao , Guo Xiangwei , Wang Zefeng , Liu Ming
Published: March 2017

To eliminate the influence of the inconsistency on the cycle life and the available capacity of the battery pack, and improve the balancing speed, a novel inductor-based layered bidirectional equalizer (IBLBE) is proposed. The equalizer is composed of the bottom balancing circuits and the upper balancing circuits, and the two layer circuits both consist of a plurality of balancing sub-circuits, which allow the dynamic adjustment of equalization path and equalization threshold. The battery string is modularized by layered balancing circuits to realize fast active equalization, especially for long battery strings. By controlling the bottom balancing circuits, the individual cells can be balanced in each module. At the same time, the equalization between battery modules can be realized by controlling the upper balancing circuits. Simulation and experimental results demonstrate that the proposed equalizer can achieve fast active equalization for a long battery string, and has the characteristics of multi balancing path, large balancing current and high accuracy. The advantages of the proposed equalizer are further verified by a comparison with existing active equalizer.
Effective Electrons Transfer Pathway of the Ternary TiO2/RGO/Ag Nanocomposite with Enhanced Photocatalytic Activity under Visible Light
Authors: Tian Hongwei , Wan Chenxing , Xue Xin , Hu Xiaoying , Wang Xiaoyi
Published: March 2017

Mesoporous TiO2/reduced graphene oxide/Ag (TiO2/RGO/Ag) ternary nanocomposite with effective electrons transfer pathway is obtained by an electrostatic self-assembly method and photo-assisted treatment. Compared with bare mesoporous TiO2 (MT) and mesoporous TiO2/RGO (MTG), the ternary mesoporous TiO2/RGO/Ag (MTGA) nanocomposite exhibited superior photocatalytic performance for the degradation of MB under visible light, and the degradation rate reached 0.017 min-1, which was 3.4 times higher than that of MTG. It is proposed that Ag nanoparticles can form the local surface plasmon resonance (LSPR) to absorb the visible light and distract the electrons into MT, and RGO can accept the electrons from MT to accelerate the separation efficiency of carriers. The establishment of MTGA ternary nanocomposite make the three components act synergistic effect to enhance the photocatalytic performance.
Improved Synthesis of Glucosyl Esters
Authors: Chen Yu , Lu Huan , Chen Yanyu , Yu Wansheng , Dai Hui , Pan Xianhua
Published: March 2017

An improved synthesis of glucosyl esters was reported here, avoiding the use of expensive Ag reagent as well as the hydrolysis of instable glucosyl bromide. Notably, ß-configuration product was exclusively obtained in good yield.
ANTIMICROBIAL ACTIVITIES OF SOME SAUDI ARABIAN HERBAL PLANTS
Authors: Shahat Abdelaaty A. , Mahmoud Elsayed A. , Al-Mishari Abdullah A. , Alsaid Mansour S.
Published: March 2017

Background: Several edible plants are used in Kingdom of Saudi Arabia since early time to control microbial

infections. In the present study, twenty-four Saudi Arabian medicinal plants d according to traditionally used were

select and investigated for the antimicrobial activities

Materials and Methods: This study was designed at evaluating the antimicrobial activities of the methanol extracts of

twenty-four species of sixteen plant families used in the traditional medicine by Saudi Arabian people for the treatment

of numerous ailments of the microbial and non-microbial origin against four Gram-positive, four Gram-negative

bacteria and four fungi and yeast using the agar well diffusion method.

Results: Of most of the plants tested were found to be active against two to eight organisms. Five plants were active

against eight organisms. The data appeared that extracts of Echium arabicum (SY-176), Rhantarium epapposum (SY-

180), Rumex vesicarus (SY-181), Ziziphus nummularia (SY-188), Caylusea hexagyna (SY-197) and Artemisia

monosperma (SY-198) have anti-microbial activity against the most of tested bacteria, fungi and yeast. Whereas (SY-

181), the extracts of Teucrium oliverianum (SY-175), Zilla spinosa (SY-187), and Rhazya stricta (SY-195) have poor

action against the tested bacteria, fungi and yeast.

Conclusion: The antimicrobial activity of plant extracts against bacteria was more effective than against fungi
ANTIBACTERIAL AND ANTIOXIDANT POTENTIAL OF STEM BARK EXTRACT OF BOMBAX CEIBA COLLECTED LOCALLY FROM SOUTH PUNJAB AREA OF PAKISTAN
Authors: Rehman Masood- ur- , Akhtar Naveed , Mustafa Rehan
Published: March 2017

Background: Ethnic medication systems have been used extensively by humans since their origin. Now a day, in the

developing countries these systems are being used due to their effectiveness and affordability. Especially inhabitants of

rural areas still rely on these systems as first line of treatment against diseased conditions. Till now, majority of medicines

is derived from the natural origin particularly plants owing to their little side effects and cost effectiveness.

Materials and Methods: In the present work, we evaluated antibacterial and antioxidant activity of methanolic extract of

Bombax ceiba stem bark. Total phenolic and flavonoid contents were also assessed in the extract. The antioxidant capacity

was determined by DPPH, Nitric Oxide scavenging and reducing power activity. For antibacterial activity, Gram-negative

(Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi) and Gram-positive bacteria (Bacillus subtilis,

Staphylococcus aureus) were used.

Results: Phenolic content was 133.21±1.56 μg GAE/mg of extract while Flavonoid content was 997.93±2.14 μg QE/mg.

Plant extract demonstrated strong antiradical activity with EC50 18.78 ± 0.69 and 23.62 ± 1.99μg/ml for Nitric Oxide and

DPPH assay respectively while EC50 in case of reducing power activity was 139.4 ± 0.98μg/ml. Plant extract displayed

inhibitory effect against microbial growth with S. typhi as the most resistant strain and Staphylococcus aureus the most

sensitive one.

Conclusion: This study revealed that Bombax ceiba of local origin has broad spectrum antibacterial activity and it can also

provide defense against oxidative stress.
THERAPEUTIC POTENTIALS OF ETHANOLIC EXTRACT OF LEAVES OF HOLARRHENA FLORIBUNDA (G. DON) DUR. AND SCHINZ (APOCYNACEAE)
Authors: Hoekou Yao Patrick , Tchacondo Tchadjobo , Karou Simplice Damintoti , Yerbanga Rakiswende Serge , Achoribo Elom , Da Ollo , Atakpama Wouyo , Batawila Komlan
Published: March 2017

Background: Holarrhena floribunda is a plant of wide usage in the Togolese folk medicine. A previous ethnobotanical

survey on the latex plants of the Maritime region of the country revealed that this plant was included in several recipes

curing malaria and microbial infections. Therefore, this study aimed to seek for the effectiveness of the ethanolic

extract of the plant in the treatment of these diseases.

Methods: The antimicrobial test was performed using the agar well-diffusion and the NCCLS broth microdilution

methods, while the in vivo antimalarial activity was evaluated following the four-day suppressive test of Peters. The

acute toxic effects of the extract were monitored after a single oral dose (5,000 mg/kg body weight) administration in

NMRI mice.

Results: The results indicated that the ethanolic extract of leaves of H. floribunda was active on Staphylococcus aureus

ATCC 29213 and clinical strains of Staphylococcus aureus, Salmonella typhi and Klebsiella pneumoniae with MICs

ranging from 0.62 to 1.25 mg/mL. The extract also showed significant parasitaemia suppression in a dose-dependent

manner. In the acute toxicity assay, the oral administration of the extract to the mice did not affect the relative weight of

vital organs, and there were no signs of toxicity or death during the study period. The LD50 of the tested extract was

found to be greater than 5,000 mg/kg, indicating its safety.

Conclusion: This study demonstrates the antibacterial and antimalarial activities of leaves of H. floribunda and then,

supports its medicinal use in the treatment of microbial infections.
EFFECT OF THAI SARAPHI FLOWER EXTRACTS ON WT1 AND BCR/ABL PROTEIN EXPRESSION IN LEUKEMIC CELL LINES
Authors: Sangkaruk Rungkarn , Rungrojsakul Methee , Tima Singkome , Anuchapreeda Songyot
Published: March 2017

Background: Saraphi (Mammea siamensis) is a Thai traditional herb. In this study, the cytotoxic effects of crude ethanolic and

fractional extracts including hexane, ethyl acetate, and methanol fractions from M. siamensis flowers were investigated in order to

determine their effect on WT1 expression in Molt4 and K562 cells and Bcr/Abl expression in K562 cells.

Materials and Methods: The flowers of M. siamensis were extracted using ethanol. The ethanol flower extract was further

fractionated with hexane, ethyl acetate, and methanol. Cytotoxic effects were measured by the MTT assay. Bcr/Abl and WT1

protein levels after treatments were determined by Western blotting. The total cell number was determined via the typan blue

exclusion method.

Results: The hexane fraction showed the strongest cytotoxic activity on Molt4 and K562 cells, with IC50 values of 2.6 and 77.6

μg/ml, respectively. The hexane extract decreased Bcr/Abl protein expression in K562 cells by 74.6% and WT1 protein

expressions in Molt4 and K562 cells by 68.4 and 72.1%, respectively. Total cell numbers were decreased by 66.2 and 48.7% in

Molt4 and K562 cells, respectively. Mammea E/BB (main active compound) significantly decreased both Bcr/Abl and

WT1protein expressions by 75 and 49.5%, respectively when compared to vehicle control.

Conclusion: The hexane fraction from M. siamensis flowers inhibited cell proliferation via the suppression of WT1 expression in

Molt4 and K562 cells and Bcr/Abl expression in K562 cells. The active compound may be mammea E/BB. Extracts from M.

siamensis flowers show promise as naturally occurring anti-cancer drugs.
INDUCTION OF CELL CYCLE ARREST AND APOPTOSIS BY ORMENIS ERIOLEPIS A MORROCAN ENDEMIC PLANT IN VARIOUS HUMAN CANCER CELL LINES
Authors: Belayachi Lamiae , Aceves-Luquero Clara , Merghoub Nawel , Mattos Silvia FernÃ¡ndez de , Amzazi SaaÃ¯d , Villalonga Priam , Bakri Youssef
Published: March 2017

Background: Ormenis eriolepis Coss (Asteraceae) is an endemic Moroccan subspecies, traditionally named “Hellala”

or “Fergoga”. It’s usually used for its hypoglycemic effect as well as for the treatment of stomacal pain. As far as we

know, there is no scientific exploration of anti tumoral activity of Ormenis eriolepis extracts.

Materials and Methods: In this regard, we performed a screening of organic extracts and fractions in a panel of both

hematological and solid cancer cell lines, to evaluate the potential in vitro anti tumoral activity and to elucidate the

respective mechanisms that may be responsible for growth arrest and cell death induction. The plant was extracted

using organic solvents, and four different extracts were screened on Jurkat, Jeko-1, TK-6, LN229, SW620, U2OS, PC-3

and NIH3T3 cells.

Results: Cell viability assays revealed that, the IC50 values were (11,63±5,37μg/ml) for Jurkat, (13,33±1,67μg/ml) for

Jeko-1, (41,67±1,98μg/ml) for LN229 and (19,31±4,88μg/ml) for PC-3 cells upon treatment with Oe-DF and Oe-HE

respectively. Both the fraction and extract exhibited no effects on TK6 and NIH3T3. Cytometry analysis accompanied

by DNA damage signaling protein levels monitoring (p-H2A.X), showed that both the Dichloromethane Fraction and

Hexanic extract induce DNA double stranded breaks (DSBs) accompanied by cell cycle arrest in G1 (Jurkat, Jeko -1

and LN22) and G2/M (PC-3) phases which is agreed with the caspase activity observed. Additional experiments with

selective inhibitors of stress and survival pathways (JNK, MAPK, Rho, p53, and JAK3) indicated that none of these

pathways was significantly involved in apoptosis induction. The bioactive compound analysis by CG/MS indicated that

the major compounds in Oe-DF were: Linoleic Acid (15,89%), Podophyllotoxin (17,89%) and Quercetin (22,95%). For

Oe-HE the major molecules were: Linoleic Acid (9,76%), α-curcumene (7,07%), α-bisabolol (5,49%), Campesterol

(4,41%), Stigmasterol (14,08%) and β-sitosterol (7,49%).

Conclusion: Our data suggest that bioactive compounds present in Ormenis eriolepis show significant anti proliferative

activity inducing cell cycle arrest and cell death operating through apoptosis pathway.
THE BIOLOGICAL ACTIVITIES OF MOLTKIA AUREA BOISS., AN ENDEMIC SPECIES TO TURKEY
Authors: Balpinar Neslihan , Okmen Gulten
Published: March 2017

Background: Staphylococcus aureus is the direct reason of mastitis. Mastitis is a disease characterized by pathological

changes in mammary glands as well as physical, chemical, bacteriological changes in milk. This disease causes loses in

milk yield and quality. In recent years, it is reported that mastitis pathogens have developed a resistance to antibiotics

as a natural consequence of widespread use of it. Today’s researches are focused on discovering and using new

antibiotics against bacteria. The aim of this paper is to examine the antibacterial properties of Moltkia aurea Boiss.][o]

(an endemic species to Turkey), and its other biological activities.

Materials and Methods: All of the extracts were tested by disc diffusion assay in order to screen antibacterial activity.

MIC values were evaluated as antibacterial activities of plant extracts. The non-enzymatic antioxidative activities

including DPPH radical scavenging effects were studied in vitro.

Results and Conclusions: Results shown that the extracts had strong antibacterial effects on three bacteria (S. aureus-

17, S. aureus-18 and CNS-37) and the range of inhibition zone was 4-6mm. This three bacteria screened the lowest

sensitivity to 65000 μg /mL concentration. Besides, the extracts were tested for non-enzymatic antioxidant activities.

As a result, the methanol extract of the flower displayed a strong antioxidant activity. The various extracts of Moltkia

aurea have different antibacterial and antioxidant properties.
ANTITUMOR AND APOPTOTIC EFFECTS OF CUCURBITACIN A IN A-549 LUNG CARCINOMA CELLS IS MEDIATED VIA G2/M CELL CYCLE ARREST AND M-TOR/PI3K/AKT SIGNALLING PATHWAY.
Authors: Wang Wen-dong , Liu Yan , Su Yuan , Xiong Xian-zhi , Shang Dan , Xu Juan-juan , Liu Hong-ju
Published: March 2017

Background: The main aim of this study was to demonstrate the antitumor potential of cucurbitacin A on A-549 NSCLC

(non-small cell lung cancer cells). The effects of Cucurbitacin A on apoptotic induction, cell physic, cell cycle failure and

m-TOR/PI3K/Akt signalling pathway were also investigated in the present study.

Materials and Methods: MTT assay and clonogenic assay were carried out to study effects of this compound on cell

cytotoxicity and colony forming tendency in A-549 cells. Moreover, phase and fluorescence microscopic techniques were

used to examine the effects on cell morphology and induction of apoptosis. The effects on cell cycle phase distribution were

investigated by flow cytometry and effects on m-TOR/PI3K/Akt signalling proteins were assessed by western blot analysis.

Results: Results showed that cucurbitacin A induced dose-dependent cytotoxic effects along with suppressing the colony

forming tendency in these cells. Cucurbitacin A also induced morphological changes in these cells featuring chromatin

condensation, cell shrinkage and apoptotic body formation. G2/M phase cell cycle collapse was also induced by

Cucurbitacin A along with inhibition of expression levels of m-TOR/PI3K/Akt proteins.

Conclusions: In conclusion, cucurbitacin A inhibits cancer growth in A-549 NSCLC cells by inducing apoptosis, targeting

m-TOR/PI3K/Akt signalling pathway and G2/M cell cycle.
BIOACTIVE COMPONENTS OF GYNURA DIVARICATA AND ITS POTENTIAL USE IN HEALTH, FOOD AND MEDICINE:A MINI-REVIEW
Authors: Xu Bing-Qing , Zhang Yu-Qing
Published: March 2017

Background: G. divaricata (L.) DC belongs to genus the Gynura Cass which is a kind of perennial herb that has good

health protection efficacy and is especially used widely in medicine and functional food. It is one of the most famous

traditional Chinese medicinal herbs and is usually used to cure bronchitis, pulmonary tuberculosis, kink cough,

rheumatism, diabetes, and so on. It has a long history for the treatment of diabetes mellitus in the folk medicine. This

review is aimed at gathering all information relating to G. divaricata and obtaining new insights for further studies on G.

divaricata

Materials and Methods: PubMed, Springer Link, Web of Science, Science Direct and Research Gate were used for the

literature search. The key search terms included G. divaricata isolation and identification, flavonoids and their

combinations without language restriction. The period for the search is from year 1979 to 2016.

Results: The main chemical components were listed, and the folk application, the extraction and separation methods of

main chemical components, pharmacological effects of G. divaricata were discussed, which further demonstrated the

plant’s value as health food and medicine.

Conclusion: The present review is of great significance to the development of new medicinal resources and health food

of G. divaricata
PURIFICATION AND FRACTIONAL ANALYSIS OF METHANOLIC EXTRACT OF WEDELIA TRILOBATA POSSESSING APOPTOTIC AND ANTI-LEUKEMIC ACTIVITY
Authors: Venkatesh Uday , Javarasetty Chethan , Murar Satish Kumar
Published: March 2017

Background: Wedelia trilobata (L.) Hitch (WT), commonly known as yellow dots or creeping daisy, is a shrub

possessing potent biological activities, and is traditionally used a medicinal plant in Ayurveda, Siddha and Unani

systems of medicines, and it has also been tried against leukemia cell line MEG- 01. In the present study, purification

and screening of the plant was done for bioactive compounds in methanolic extract of WT for apoptotic and antileukemia

activity.

Materials and methods: The methanolic extract of WT was initially purified through thin layer chromatography

(TLC) and screened for the apoptotic and anti-leukemia activities. The positive band of TLC was subjected to silica gel

column chromatography for further purification and the fractions obtained from it were screened again for antileukemia

activity through thymidine uptake assay and apoptotic activity by DNA fragmentation, nuclear staining and

flow cytometry assays. The fraction with positive result was subjected to HPLC for analysis of bioactive components.

Results: Out of many combinations of solvents, the methanol and dichloromethane combination in the ratio 6:4 has

revealed two bands in TLC, among which the second band showed positive results for apoptotic and anti-leukemic

activities. Further purification of second band through silica gel chromatography gave five fractions in which the 3rd

fraction gave positive results and it shows single peak during compositional analysis through HPLC.

Conclusion: The single peak revealed through HPLC indicates the presence of pure compound with apoptotic and antileukemia

activities encouraging for further structural analysis.
ANTI-VIRAL EFFECT OF HERBAL MEDICINE KOREAN TRADITIONAL CYNANCHUM PANICULATUM (BGE.) KITAG EXTRACTS
Authors: Kim Woong , Oh Tae-Seok , Park Youn-Jin
Published: March 2017

Background: Pestiviruses in general, and Bovine Viral Diarrhea (BVD) in particular, present several potential targets

for directed antiviral therapy.

Material and Methods: The antiviral effect of Cynanchum paniculatum (Bge.) Kitag (Dog strangling vine: DS)

extract on the bovine viral diarrhea (BVD) virus was tested. First, a cytotoxicity test in MDBK (Madin-Darby bovine

kidney) cells was done with all organic extract concentrations.

Results: The cytotoxic concentration CC50 for the ethyl acetate (EA) extracts was 18.2 ug/ml. In the tissue culture,

infectious dose (TCID50) assay, the BVD virus decreased when treated with 18.2 ug/ml of the ethyl acetate extracts.

Conclusion: Ethyl acetate extracts and fractions of the DS extract could be used as a potential antiviral for BVD.
INVESTIGATION ON CHEMICAL COMPOSITION, ANTIMICROBIAL, ANTIOXIDANT, AND CYTOTOXIC PROPERTIES OF ESSENTIAL OIL FROM DRACOCEPHALUM KOTSCHYI BOISS
Authors: Ashrafi Behnam , Ramak Parvin , Ezatpour Behrouz , Talei Gholam Reza
Published: March 2017

Background: Dracocephalum kotschyi Boiss is a herb with wide-spread applications. Lorestan traditional healers have

applied it for the treatment of rheumatoid diseases and stomach disorders.

Materials and methods: Hydrodistillation process was used for essential oil extraction, the extracted essential oil was

then analyzed through combination of capillary GC–FID, GC–MS and RI. The in vitro antimicrobial, antioxidant and

cytotoxic activities of this essential oil were examined. Results indicate that the essential oil has a broad range of antimicrobial

activity against all of the tested microorganisms.

Results: The 50% of cytotoxic concentrations was 26.4 μg/ml and 4266.7 μg/ml for Hela cells and human

lymphocytes, respectively. The oil cytotoxicity against the human tumor cell line was far higher than the amount

required for human healthy cells. Conversely, the essential oil’s IC50 value of 49.2 μg/ml in the DPPH assay, could be

regarded as its strong antioxidant potential.

Conclusion: According to the data obtained, it can be concluded that D. kotschyi essential oil could be applied as a safe

antibacterial and antioxidant agent for food and pharmaceutical purposes.
SURVEY OF DENTAL STUDENTS’ ATTITUDE REGARDING ORIENTAL MEDICINE/COMPLEMENTARY AND ALTERNATIVE MEDICINE: COMPARISON BETWEEN TWO JAPANESE DENTAL SCHOOLS
Authors: Kameyama Atsushi , Toda Kazuo
Published: March 2017

Background: The present study aimed to examine the impact of “curricula for undergraduate education in oriental

medicine (OM)/complementary and alternative medicine (CAM)” on student awareness of OM. A questionnaire survey

was conducted involving the Nagasaki University School of Dentistry (NUSD), a university that implements education

in OM as part of its undergraduate curriculum, and Tokyo Dental College (TDC), which does not teach OM.

Materials and methods: The third- and fifth-year students of both NUSD and TDC underwent the anonymous

questionnaire survey, which included questions regarding their knowledge of OM and CAM, interests in these subjects,

and their opinions on the necessity of teaching OM in the undergraduate dental education, and the results were

collected for analysis.

Results: Whereas 33% of 5th year NUSD students had knowledge of OM/CAM was 33%, only 10% of 5th year TDC

students reported knowledge on the subject. 69% of 5th year NUSD students interested in OM/CAM, while 5th year

TDC students who interest them were only 45%. Although 77% of 5th year NUSD students were in favor of OM

education implemented in the Faculty of Dentistry, the percentages of TDC students of that were smaller (46% in 3rd

year and 48% in 5th year). Whereas 26% of 5th year TDC students did not recognize the necessity of oriental medicine

education, only one 5th year NUSD student (2%) did not so.

Conclusion: Introduction of education in OM in the undergraduate dental education program helps students to increase

their interests in dental clinical applications.
IN VITRO EFFECTS OF A COMMERCIAL HERBAL MEDICINE USED AS AFRICAN TRADITIONAL MEDICINE ON HUMAN NEUTROPHILS
Authors: Mothibe Mmamosheledi Elsie , Kahler-Venter Christinah , Osuch Elzbieta
Published: March 2017

Background: Commercial herbal medicines (CHMs) being marketed as immune boosters or tonics, have gained

widespread popularity. The many herbal mixtures sold have not been tested for efficacy and safety, despite their

modern packaging and presentations. It is imperative that these herbal mixtures be investigated for their effects on

human neutrophils.

Methods: The selected herbal mixture (HM), Stametta™ Body healing liquid, is common in retail outlets in Pretoria,

South Africa (SA) and is used as an immune booster or intended to strengthen the body. Isolated neutrophils as well as

those in whole blood phagocytes were obtained from blood samples collected from consenting healthy adult volunteers.

The neutrophils were incubated with the HM at different strengths, and taken through a luminol-enhanced

luminescence assay, using activators- phorbol myristate acetate and N-formyl-methionyl-leucyl-phenylalanine.

Results: The HM had variable stimulatory and inhibitory effects on the luminescence activity of healthy isolated and

non-isolated human neutrophils. The effects, ranging from weak to potent were either directly or inversely related to

the concentration of the HM and were mediated through a direct protein kinase C activating mechanism and an indirect

formyl peptide receptor-linked mechanism.

Conclusion: The findings have shown the immunomodulatory potential of Stametta TM. The in vitro inhibitory and

stimulatory effects on neutrophils which are furthermore time-based, suggest variable effects on the immune system,

which may be beneficial as well as risky. The effects at different concentrations highlight the importance of appropriate

dosing. It would therefore be prudent to caution users of this commercial herbal medicine accordingly.
Para onde nos leva a principal política de mobilidade urbana na Região Metropolitana do Recife? Do Modelo Tradicional às Novas percepções sobre desenvolvimento
Authors: Béhar Alexandre Hochmann , Dourado Débora Paschoal
Published: March 2017

Diversas são as críticas direcionadas ao modelo tradicional de desenvolvimento, marcado pelo viés econômico. Neste sentido, o Estado apresenta-se como principal agente, a cidade o palco desta crise, e a mobilidade urbana uma de suas significativas representações. Assim, este estudo se propõe a analisar as perspectivas de desenvolvimento subjacentes a uma política pública de mobilidade urbana na Região Metropolitana do Recife. Foi realizada uma pesquisa qualitativa básica, consolidada por meio da análise de conteúdo, cujos resultados apresentados indicam que, apesar do discurso dos governantes, tais políticas públicas ainda encontram-se direcionadas às antigas práticas desenvolvimentistas.
Stromme Syndrome: New Clinical Features
Authors: Dorum Bayram Ali , Tanal Şambel Irmak , Özkan Hilal , Kırıştıoğlu İrfan , Köksal Nilgün
Published: March 2017

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Peningkatan keterampilan proses sains melalui percobaan sederhana anak usia 5-6 tahun di TK-IT Albina Ternate
Authors: Wahid Santi M. J. , Suyanto Slamet
Published: March 2017

Penelitian ini bertujuan untuk mengetahui peningkatan keterampilan proses sains melalui percobaan sederhana pada anak usia 5-6 tahun di TK IT Albina Kota Ternate. Jenis penelitian ini adalah penelitian tindakan kelas (kolaboratif) yang terdiri dari tiga siklus & enam pertemuan. Subjek penelitian adalah anak-anak kelas B2 yang berjumlah 19 anak terdiri dari 8 anak laki-laki dan 11 anak perempuan. Teknik pengumpulan data yaitu observasi dan catatan lapangan. Instrumen menggunakan lembar observasi Keterampilan Proses Sains (KPS) anak dan lembar observasi kegiatan guru selama kegiatan pembelajaran. Data yang terkumpul dianalisis secara deskriptif  kualitatif dan kuantitatif. Hasil penelitian ini menunjukkan bahwa peningkatan keterampilan proses sains anak secara keseluruhan pada siklus I sebesar 59,38%, siklus II sebesar 66,12% dan siklus III sebesar 78,82% dengan keterampilan proses sains masing-masing indikator KPS selama tiga siklus sebagai berikut: (1) KPS Membuat dugaan adalah 53,84%, 60,53%, 73,55%, (2) KPS mengamati adalah 65,02%, 71,71%, 85%, (3) KPS mengklasifikasi adalah 64,25%, 69,08%, 84,01%, dan (4) KPS mengkomunikasikan sebesar 54,39%, 63,08%, 72,70%. Aktivitas kegiatan guru mengalami peningkatan sebesar 36,84% dan 47,37% siklus I, 63,16% dan 73,68% siklus II, 89,47% dan 94,74% siklus III.Kata kunci: keterampilan proses sains, percobaan sederhana, anak usia 5-6 tahun Improving KPS Through the Simple Experiment for the 5-6 Year-Old Students in TK-IT Albina Ternate AbstractThis research is aimed to find out the improvement of the science skill through the simple experiment for the 5-6 year-old students in TK IT Albina, Ternate. This research was a Classroom Action Research (collaborative) consisted of three cycles with six meetings. The subjects of the research were the students of Class B2 in TK IT Albina Ternate which were 19 students consisting of 8 boys and 11 girls. The data collection techniques were by observing and making field notes. The instruments of the research used the students Science Process Skills (SPS) observation sheets and teacher observation sheets during the process of studying. The data then were analyzed by using descriptive qualitative and quantitative methods. The results of this research indicats the improvement of science process skill entirely in the Cycle I is 59.38 %, in Cycle II is 66.12%, and in Cycle III is 78.82% with each SPS indicator as (1) SPS made judgment is 53.84%, 60.53%, 73.55%, (2) SPS observing is 65.02%, 71.71%, and 85%, (3) SPS classifiying is 64.25%, 69.08%, 84.01%, and (4) SPS communicating is 54.39%, 63.08%, 72.70%. In Cycle I The teacher’s activities improve from 36.84% to 47.37%, in Cycle II much as 63,16% and 73.68%, and in cycle III is 89.47%.Keywords: science process skill, simple experiment, 5-6 years-old students