bluuebunny/crossref_metadata_2025 huggingface dataset:
Satisfaction with Life and Coping Strategies among Patients with Hidradenitis Suppurativa: A Cross-Sectional Study
Authors: Rymaszewska Julia E. , Krajewski Piotr K. , Matusiak Łukasz , Maj Joanna , Szepietowski Jacek C.
Published: April 2023

Introduction: Hidradenitis suppurativa (HS) is a chronic recurrent inflammatory dermatosis with vast psychosocial burden. The objective of this study is to thoroughly analyze satisfaction with life (SWL) and coping strategies of HS patients in relation to the clinical and psychosocial factors. Methods: 114 HS patients (53.1% females; mean age 36.6 ± 13.1 years) were enrolled. Severity of the disease was measured using Hurley staging and International HS Score System (IHS4). Instruments utilized: Satisfaction with Life Scale (SWLS); Coping-Orientation to Problems-Experienced Inventory (Brief COPE); HS Quality of Life Scale (HiSQoL); Patient Health Questionnaire-9 (PHQ-9); Generalized Anxiety Disorder-7 (GAD-7); General Health Questionnaire (GHQ-28). Results: SWL was low in 31.6% of HS patients. No relation was found between SWL and Hurley staging and IHS4. SWL correlated with GHQ-28 (r = −0.579 p < 0.001), PHQ-9 (r = −0.603 p < 0.001), GAD-7 (r = −0.579 p < 0.001), and HiSQoL (r = −0.449 p < 0.001). Problem-focused coping strategies were most commonly used, followed by emotion-focused coping and avoiding coping strategies. Significant differences were found between the following coping strategies and SWL: self-distraction (p = 0.013), behavioral-disengagement (p = 0.001), denial (p = 0.003), venting (p = 0.019), and self-blame (p = 0.001). Conclusions: HS patients present low SWL which correlates with psychosocial burden. Reducing anxiety–depression comorbidity and encouraging optimal coping strategies may be of great importance in holistic approach to HS patients.
Analysis of Clinical Characteristics of Patients with Recurrent Cytomegalovirus Retinitis after Hematopoietic Stem Cell Transplantation
Authors: Wang Xiaona , Lu Yao , Li Haiping , Ma Zhizhong , Hong Jing , Wang Changguan
Published: April 2023

Objective: To analyze and summarize the clinical and imaging characteristics of patients with cytomegalovirus retinitis (CMVR) relapse after hematopoietic stem cell transplantation (HSCT). Methods: This retrospective case series study recruited patients with CMVR after HSCT. The study compared the patients with stable lesions and CMV-negative aqueous humor after treatment with those with relapse lesions and a CMV DNA load in aqueous humor which had increased again after treatment. The observation indexes were basic clinical information, best-corrected visual acuity, wide-angle fundus photography, optical coherence tomography (OCT), blood CD4+ T lymphocyte count, and aqueous humor CMV load of the patients. We summarized the data and statistically analyzed the differences between the relapse and non-relapse groups, as well as the correlations of the observed indicators. Results: The study recruited 52 patients with CMVR (82 eyes) after HSCT, of whom 11 patients (15 eyes) had recurrence after treatment (21.2%). The recurrence interval was 6.4 ± 4.9 months. The final best-corrected visual acuity of recurrent patients was 0.3 ± 0.3. The number of CD4+ T lymphocytes in recurrence patients at the time of onset was 126.7 ± 80.2/mm3. The median CMV DNA load detected in aqueous humor at the time of recurrence was 8.63 × 103 copies/mL. There was a significant difference in the CD4+ T lymphocyte count between the recurrence and the non-recurrence groups at onset. The onset of visual acuity in recurrence patients was significantly correlated with final visual acuity and recurrence lesion area. The fundus of recurred CMVR showed increased marginal activity of the original stable lesion. Concurrently, yellow-white new lesions appeared around the stable, atrophic, and necrotic lesions. OCT showed new diffuse hyperreflexic lesions in the retinal neuroepithelial layer near the old lesions. Inflammatory punctate hyperreflexes were observed in the vitreous, with vitreous liquefaction and contraction. Conclusion: This study suggests that the clinical features, fundus manifestations, and imaging features of CMVR recurrence after HSCT are different from those at the initial onset. Patients should be closely followed up after their condition is stable to be alert for CMVR recurrence.
Recent Advancements on the Use of Exosomes as Drug Carriers for the Treatment of Glioblastoma
Authors: Galardi Angela , De Bethlen Alexander , Di Paolo Virginia , Lampis Silvia , Mastronuzzi Angela , Di Giannatale Angela
Published: April 2023

Glioblastoma (GBM) is the most common and aggressive cancer of the brain. Presently, GBM patients have a poor prognosis, and therapy primarily aims to extend the life expectancy of affected patients. The current treatment of GBM in adult cases and high-grade gliomas in the pediatric population involves a multimodal approach that includes surgical resection followed by simultaneous chemo/radiotherapy. Exosomes are nanoparticles that transport proteins and nucleic acids and play a crucial role in mediating intercellular communication. Recent evidence suggests that these microvesicles may be used as biological carriers and offer significant advantages in targeted therapy. Due to their inherent cell-targeting properties, circulation stability, and biocompatibility, exosomes are emerging as promising new carriers for drugs and biotherapeutics. Furthermore, these nanovesicles are a repository of potential diagnostic and prognostic markers. In this review, we focus on the therapeutic potentials of exosomes in nano-delivery and describe the latest evidence of their use as a therapeutic tool in GBM.
The Impact of Ammonia Fuel on Marine Engine Lubrication: An Artificial Lubricant Ageing Approach
Authors: Agocs Adam , Rappo Maria , Obrecht Nicolas , Schneidhofer Christoph , Frauscher Marcella , Besser Charlotte
Published: April 2023

Ammonia is a prospective zero-carbon-emission fuel for use in large marine diesel engines. Current research focuses on several technical aspects, such as injection strategies or exhaust gas aftertreatment options, but investigations regarding the impact of ammonia on engine oil degradation are largely absent from the literature. This study provides a methodology with which to evaluate this phenomenon via artificial oil alteration. By using an admixture of various contaminations to air, such as ammonia and its partial combustion product nitrogen dioxide, their respective impacts on chemical oil degradation were assessed. Subsequently, the lubricating performance of altered oils was investigated, with a focus on corrosion properties, deposit formation, and load-bearing capability. Although the application of a stoichiometric ammonia–air mixture resulted in less pronounced thermo-oxidative degradation compared to alteration with neat air, static and dynamic deposit formation as well as corrosion properties and load-bearing capability were severely impacted by the presence of ammonia. On the contrary, nitrogen dioxide contamination resulted in higher oxidation and acidification of the oil, but altered samples performed considerably better than ammonia-altered aliquots in terms of coking tendencies, corrosivity, and load bearing.
Extraction of Copper from Sulfuric Acid Solutions Based on Pseudo-Liquid Membrane Technology
Authors: Kostanyan Artak E. , Belova Vera V. , Zakhodyaeva Yulia A. , Voshkin Andrey A.
Published: April 2023

Pseudo-liquid membranes are extraction devices in which a liquid membrane phase is retained in an apparatus consisting of two interconnected chambers while feed and stripping phases pass through the stationary liquid membrane phase as mobile phases. The organic phase of the liquid membrane sequentially contacts the aqueous phases of the feed and stripping solutions in the extraction and stripping chambers, recirculating between them. This extraction separation method, called multiphase pseudo-liquid membrane extraction, can be implemented using traditional extraction equipment: extraction columns and mixer-settlers. In the first case, the three-phase extraction apparatus consists of two extraction columns connected at the top and bottom by recirculation tubes. In the second case, the three-phase apparatus consists of a recycling close-loop, which includes two mixer-settler extractors. In this study, the extraction of copper from sulfuric acid solutions in two-column three-phase extractors was experimentally studied. A 20% solution of LIX-84 in dodecane was used as the membrane phase in the experiments. It was shown that the extraction of copper from sulfuric acid solutions in the apparatuses studied was controlled by the interfacial area in the extraction chamber. The possibility of the purification of sulfuric acid wastewaters from copper using three-phase extractors is shown. To increase the degree of extraction of metal ions, it is proposed to equip two-column three-phase extractors with perforated vibrating discs. To further increase the efficiency of extraction using the pseudo-liquid membrane method, it is proposed to use multistage processes. The mathematical description of multistage three-phase pseudo-liquid membrane extraction is discussed.
Metallurgical Failure Analysis of Closed Water Circuit Containing Molybdate-Based Inhibitor
Authors: Casaroli Andrea , Boniardi Marco Virginio , Rivolta Barbara , Gerosa Riccardo , Iacoviello Francesco
Published: April 2023

In this work, two industrial heating/cooling circuits are compared. One of the two systems failed in a short time showing severe corrosion damage and a through thickness crack close to one of the welds. The main difference between the circuits is the presence of a sodium molybdate-based corrosion inhibitor in the damaged one. The addition of these substances is very frequent in such applications, and they generally work very well in preventing serious corrosion attacks. Nevertheless, the technical literature reports other cases in which systems working with fluids containing such inhibitors failed prematurely. The authors performed a failure analysis of the damaged circuit focusing their attention on the regions where fluid leaks were observed because of through thickness cracks. This damage was located close to the pipe–flange weld. These zones were investigated by visual examination, radiographic and scanning electron microscope (SEM) analyses, metallographic observations by light optical microscope (LOM), Vickers micro-hardness tests and optical emission spectroscopy (OES) chemical analysis. The failure was related to the presence of severe pitting and crevice corrosion in the welded areas with the final activation of a further critical corrosion mechanism, i.e., stress corrosion cracking (SCC). In order to explain the shorter working life of the failed system, a physical model of the corrosion mechanisms acting on the two circuits was proposed.
Maltooligosaccharides: Properties, Production and Applications
Authors: Bláhová Mária , Štefuca Vladimír , Hronská Helena , Rosenberg Michal
Published: April 2023

Maltooligosaccharides (MOS) are homooligosaccharides that consist of 3–10 glucose molecules linked by α-1,4 glycosidic bonds. As they have physiological functions, they are commonly used as ingredients in nutritional products and functional foods. Many researchers have investigated the potential applications of MOS and their derivatives in the pharmaceutical industry. In this review, we summarized the properties and methods of fabricating MOS and their derivatives, including sulfated and non-sulfated alkylMOS. For preparing MOS, different enzymatic strategies have been proposed by various researchers, using α-amylases, maltooligosaccharide-forming amylases, or glycosyltransferases as effective biocatalysts. Many researchers have focused on using immobilized biocatalysts and downstream processes for MOS production. This review also provides an overview of the current challenges and future trends of MOS production.
Tuning Photophysical Properties via Positional Isomerization of the Pyridine Ring in Donor–Acceptor-Structured Aggregation-Induced Emission Luminogens Based on Phenylmethylene Pyridineacetonitrile Derivatives
Authors: Sun Haiya , Chen Shuixin , Zhong Aiguo , Sun Rong , Jin Jiajie , Yang Jiahao , Liu Dongzhi , Niu Junfeng , Lu Shengli
Published: April 2023

A series of aggregation-induced emission (AIE)-featured phenylmethylene pyridineacetonitrile derivatives named o-DBCNPy ((Z)-3-(4-(di-p-tolylamino)phenyl)-2-(pyridin-2-yl)acrylonitrile), m-DBCNPy ((Z)-3-(4-(di-p-tolylamino)phenyl)-2-(pyridin-3-yl)acrylonitrile), and p-DBCNPy ((Z)-3-(4-(di-p-tolylamino)phenyl)-2-(pyridin-4-yl)acrylonitrile) have been synthesized by tuning the substitution position of the pyridine ring. The linkage manner of the pyridine ring had influences on the molecular configuration and conjugation, thus leading to different photophysical properties. The absorption and fluorescence emission peak showed a bathochromic shift when the linking position of the pyridine ring changed from the meta to the ortho and para position. Meanwhile, o-DBCNPy exhibited the highest fluorescence quantum yield of 0.81 and the longest fluorescence lifetime of 7.96 ns as a neat film among all three isomers. Moreover, non-doped organic light-emitting diodes (OLEDs) were assembled in which the molecules acted as the light-emitting layer. Due to the relatively prominent emission properties, the electroluminescence (EL) performance of the o-DBCNPy-based OLED was superior to those of the devices based on the other two isomers with an external quantum efficiency (EQE) of 4.31%. The results indicate that delicate molecular modulation of AIE molecules could endow them with improved photophysical properties, making them potential candidates for organic photoelectronic devices.
Evaluating the Probiotic Potential of Lactic Acid Bacteria Implicated in Natural Fermentation of Table Olives, cv. Cobrançosa
Authors: Coimbra-Gomes Joana , Reis Patrícia J. M. , Tavares Tânia G. , Faria Miguel A. , Malcata F. Xavier , Macedo Angela C.
Published: April 2023

The probiotic features of Lactiplantibacillus (L.) pentosus and L. paraplantarum strains, endogenous in Cobrançosa table olives from northeast Portugal, were assessed in terms of functional properties and health benefits. Fourteen lactic acid bacteria strains were compared with Lacticaseibacillus casei from a commercial brand of probiotic yoghurt and L. pentosus B281 from Greek probiotic table olives, in attempts to select strains with higher probiotic performances than those references. For functional properties, the i53 and i106 strains, respectively, exhibited: 22.2 ± 2.2% and 23.0 ± 2.2% for Caco-2 cell adhesion capacity; 21.6 ± 7.8% and 21.5 ± 1.4% for hydrophobicity; 93.0 ± 3.0% and 88.5 ± 4.5% for autoaggregation ability by 24 h of incubation; and ability to co-aggregate with selected pathogens—from 29 to 40% to Gram+ (e.g., Staphylococcus aureus ATCC 25923 and Enterococcus faecalis ATCC 29212); and from 16 to 44% for Gram− (e.g., Escherichia coli ATCC 25922 and Salmonella enteritidis ATCC 25928). The strains proved to be resistant (i.e., halo zone ≤14 mm) to some antibiotics (e.g., vancomycin, ofloxacin, and streptomycin), but susceptible (i.e., halo zone ≥ 20 mm) to others (e.g., ampicillin and cephalothin). The strains exhibited health-beneficial enzymatic activity (such as acid phosphatase and naphthol-AS-BI-phosphohydrolase), but not health-harmful enzymatic activity (such as β-glucuronidase and N-acetyl-β-glucosaminidase). Additionally, the antioxidant activity and cholesterol assimilation features, respectively, of the strains were 19.6 ± 2.8% and 77.5 ± 0.5% for i53, and 19.6 ± 1.8% and 72.2 ± 0.9% for i106. This study indicated that the addition of L. pentosus strains i53 and/or i106 to Cobrançosa table olives is likely to enhance the added value of the final product, in view of the associated potential benefits upon human health.
Prevalence and Molecular Characterisation of Blastocystis sp. Infecting Free-Ranging Primates in Colombia
Authors: Rondón Silvia , Cavallero Serena , Link Andrés , González Camila , D’Amelio Stefano
Published: April 2023

Infection with Blastocystis sp. has been reported in free-living and captive non-human primates (NHPs); however, surveys on Blastocystis sp. from north-western South America are scarce. This study aimed to identify Blastocystis sp. in free-ranging NHPs living in Colombia. A total of 212 faecal samples were collected from Ateles hybridus, Cebus versicolor, Alouatta seniculus, Aotus griseimembra, Sapajus apella, and Saimiri cassiquiarensis. Smears and flotation were used for morphological identification. For samples microscopically classified as positive for Blastocystis sp., we used conventional PCR to amplify and sequence two regions of the SSU rRNA gene and used Maximum Likelihood methods and Median Joining Network analyses for phylogenetic analyses. Via microscopy, 64 samples were Blastocystis sp. positive. Through molecular analyses, 18 sequences of Blastocystis sp. subtype 8 (ST8) were obtained. Strain and allele assignment together with a comparative phylogenetic approach confirmed that the sequences were ST8. Alleles 21, 156, and 157 were detected. Median Joining network analyses showed one highly frequent haplotype shared by specimens from Colombia and Peru and close relationships between haplotypes circulating in NHPs from Colombia, Ecuador, Brazil, and Mexico. This survey could support the elaboration of a more accurate epidemiological picture of the Blastocystis sp. infecting NHPs.
Simplified Genomic Data Revealing the Decline of Aleuritopteris grevilleoides Population Accompanied by the Uplift of Dry-Hot Valley in Yunnan, China
Authors: Wei Xue-Ying , Wang Ting , Zhou Jin , Sun Wei-Yue , Jin Dong-Mei , Xiang Jian-Ying , Shao Jian-Wen , Yan Yue-Hong
Published: April 2023

Understanding the evolutionary history of endangered species is crucial for identifying the main reasons for species endangerment in the past and predicting the changing trends and evolutionary directions of their future distribution. In order to study the impact of environmental changes caused by deep valley incision after the uplift of the Qinghai-Tibet Plateau on endangered species, we collected 23 samples belonging to four populations of Aleuritopteris grevilleoides, an endangered fern endemic to the dry-hot valleys (DHV) of Yunnan. Single-nucleotide variation sites (SNPs) were obtained by the genotyping-by-sequencing (GBS) method, and approximately 8085 SNP loci were identified. Through the reconstruction and analysis of genetic diversity, population structure, population dynamics, evolution time, and ancestral geographical distribution, combined with geological historical events such as the formation of dry-hot valleys, this study explores the formation history, current situation, reasons for endangerment and scientifically sound measures for the protection of A. grevilleoides. In our study, A. grevilleoides had low genetic diversity (Obs_Het = 0.16, Exp_Het = 0.32, Pi = 0.33) and a high inbreeding coefficient (Fis = 0.45). The differentiation events were 0.18 Mya, 0.16 Mya, and 0.11 Mya in the A. grevilleoides and may have been related to the formation of terraces within the dry-hot valleys. The history of population dynamics results shows that the diversion of the river resulted in a small amount of gene flow between the two clades, accompanied by a rapid increase in the population at 0.8 Mya. After that, the effective population sizes of A. grevilleoides began to contract continuously due to topographic changes resulting from the continuous expansion of dry-hot valleys. In conclusion, we found that the environmental changes caused by geological events might be the main reason for the changing population size of A. grevilleoides.
LIFE, WORK AND EDUCATION DURING A PANDEMIC (SELECTED ISSUES FROM AN INTERNATIONAL PERSPECTIVE)
Authors: Piwowarski R.
Published: April 2023

The article presents only some of the issues related to the effects of the pandemic on most spheres of life. New problems and studies are likely to arise. In the field of education probably there will be those in which the issues related to the quality of teaching and perception of acquired knowledge and skills should be analyzed.
THE POLYPEDAGOGICAL PRINCIPLE OF TEACHING BY ANTONIO SALIERI AND THE MODERN UNDERSTANDING OF POLYPEDAGOGICAL EFFECTIVENESS
Authors: Yaremenko L.
Published: April 2023

The article deals with the polypedagogical principle of Antonio Salieri's education in the context of the modern understanding of the polypedagogical reality, its phenomenality, and its unique features. The author examines modern trends in the formation of polypedagogical reality, the point of view of scientists on scientific approaches to the description of pedagogical reality. In the context of the works of representatives of artistic pedagogy, the polypedagogical principle in the teaching activity of Antonio Salieri is analyzed. It provided for the ability of one teacher to teach students to play an instrument, vocals, composition, solfeggio, harmony, instrumentation, music theory, polyphony, heterophony, homophony, the basics of counterpoint, and conducting. In the modern plane of «polypedagogical interaction» (work with a student group of several teachers), the main problems for musicians arise when several teachers work with groups (with a choir or an orchestra, where students of the first and second levels of higher education are trained). Such a situation simply cannot pass without a certain number of socio-psychological dilemmas - the problem of the psychological compatibility of teachers (individual-personal, psychophysiological, didactic), the problem of the compatibility of the technologies of these teachers and their teaching styles, the issue of the interaction of the leaders of educational groups with their participants and among themselves. The article shows optimal ways that require the teacher's moral responsibility and moral readiness for "subject-subject" and "subject-object-subject" interactions in large groups. In the context of dyadic and frontal relations between the teacher and students, the author proved that Antonio Salieri, who was uniquely able to coordinate and establish positive relations with the students who studied under him, quickly and simply gained authority, caused sympathy, sincere love among the students, the desire to be like him, to consider him a role model.
PRINCIPLES OF PROFESSIONAL DEVELOPMENT AS REGULATORY NORMS OF THE TEACHER'S PRACTICAL ACTIVITY
Authors: Tovkanets H.
Published: April 2023

The article substantiates the principles of professional development as regulatory norms of the teacher's practical activity. It is noted that the principles always reflect the dependence between the objective regularities of the educational process and its goals. It is a methodical expression of the laws of cognition and regularities, knowledge of the goals, essence, content, and structure of training (education), which is expressed in a form that allows them to be used as regulatory norms of pedagogical practice. The following principles of professional development of teachers are characterized: the principle of continuity, diversification, and synergistic principle; the principles of participation, reflective management of professional training, the principle of communicative partnership and cooperation; principles of facilitation, subjectivity, and electivity. It is emphasized that the innovative development of education is based on the directions of education development and specially developed principles, on the basis of which systemic changes should take place, ensuring its availability, quality, continuity, and investment attractiveness. It is determined that the teacher's professional development acts as a way and means of creative growth of the individual, constructive overcoming of situations of social and professional life crisis. The essence of a teacher's professional development can be presented as comprehensive in its entirety, and individualized in terms of time, pace, and direction, which provides everyone with the opportunity to implement their own program for obtaining it. Continuous additional professional education is the development of a person as an individual throughout his life path. The specificity of the professional development of a teacher consists in the formation of individual consciousness, spiritual and moral values, the development of the artistic and creative potential of an individual, emotional self-regulation, and assumes a continuous, purposeful, dynamic process of interaction between educational structures and social and cultural institutions. It is concluded that the principles of education in Ukraine are a phenomenon of the worldview foundations of educational activity in general. However, the specificity of knowledge determines the institutional necessity of the principles of professional development.
FEATURES OF THE COMMUNICATIVE COMPONENT DEVELOPMENT OF THE NUS TEACHER’S PSYCHOLOGICAL READINESS FOR PROFESSIONAL ACTIVITY
Authors: Ivanova O.
Published: April 2023

The article reveals the problematic aspects of the situation in which Ukrainian teachers found them in connection with the war in Ukraine, who are an intellectual, emotional, and social "resource" for the formation of the younger generation. Due to household, housing, financial and technical difficulties, as well as negative psychological conditions, not all teachers can effectively implement their mission. This problem posed to the psychologists-scientists the task of researching the psychological readiness of the teachers of the NUS for professional activity in the conditions of the war and in the post-war period, in particular, the peculiarities of the development of its communicative component.The author of the article highlighted the results of the research on the development of the communicative component of the psychological readiness of the teacher of the New Ukrainian School for professional activity. The studied phenomenon is defined as a set of purely communicative qualities of a person, his moral-communicative features, and psychological-pedagogical skills, the structure of which is formed by communicative, empathic-reflective, moral-ethical, and emotional-regulatory components. The author reveals the importance of the development of the communicative competence of the teacher of NUS as an indicator of the development of emotional intelligence and psychological readiness for professional activity during the war.
FEATURES OF FORMATION OF FUTURE MUSIC TEACHER’S COMPETENCE IN WORKING WITH CHILDREN'S CHOIR
Authors: Yunda V.
Published: April 2023

The article reveals the peculiarities of the formation of future music teachers' competence in working with children's choirs. It is emphasized that the formation of future professionals' competence is an essential condition for the development of the musical culture of the younger generation, children's interest in the traditions of the musical culture of the Ukrainian people's creative music, and vocal and choral work in children's choir promotes musical abilities and emotional sphere. It is proven that the professional training of future music teachers to work with children's school choirs should be creative, taking into account individual capabilities, music theory, and performance training of students. It is revealed that the future music teacher must be prepared for various types and forms of creative vocal and choral work with children of different school ages, in which the future music teacher will perform as an educational institution, accompanist, accompanist, and illustrator.

It is emphasized that the modern school needs new forms and methods in the organization of musical activity for schoolchildren, which will promote the development of musical culture and interest of pupils in musical creativity.
METHODICAL PREREQUISITES FOR TRAINING MUSIC TEACHERS TO TEACH ART TO PUPILS
Authors: Ying Yue
Published: April 2023

The purpose of the article is to analyze the requirements of general school education regarding the education of art students as determinants of the professional future music teacher methodical training. Scientific sources of Ukrainian and Chinese art pedagogy were involved in the theoretical analysis. The analysis was carried out in the context of identifying the potential of the achievements of Ukrainian artistic pedagogy and science for their possible introduction into the Chinese music and music-pedagogical education system, which is currently being integrated into the world's cultural process. The methods of theoretical analysis are used to determine the essence of the fundamental definition of the music teacher's readiness to teach art students, comparing the positions of scientists to reveal the essence of the requirements for the complex of methodical training of music teachers in Ukraine and China. The analysis of music teacher training requirements in the Ukrainian education system is based on the conceptual ideas of the New Ukrainian School. The differences in the ways of musical and pedagogical education formation in China in the context of historical and cultural processes and national specificities are shown. The joint determinant of the successful teacher-musician's professional activity in the direction of integrative art education of pupils is formulated. It is multi-artistic readiness centered on musical art and systematically encompasses other types of art in practical creativity. The qualities of a music teacher, which are aimed at successful professional activity, are described: as universal, musical and professional (professional musicianship and music-pedagogical), and personal. The content structure of teacher-musician training in teaching art to pupils has been specified, which includes artistic-reflective, artistic-empathic, motivational-value, artistic-active, and artistic-communicative components. Emphasis is placed on increasing the requirements for the spiritual and personal development of the music teacher in the regulatory documents and practice of Chinese music-pedagogical education.
FORMATION OF PRIMARY SCHOOL CHILDREN’S ENVIRONMENTAL COMPETENCE BY MEANS OF THE ECOLOGICAL TRAIL
Authors: Fediy O. , Makarenko Ya. , Miroshnichenko T.
Published: April 2023

The article examines the peculiarities of the ecological path organization as an effective means of younger schoolchildren's ecological competence formation. The content and structure of the pupils' environmental competence are characterized in accordance with the State Standard of General Primary Education. The essence of environmental competence of primary school pupils is revealed as the ability to apply environmental knowledge and effectively solve environmental issues they face in everyday life. The following components are distinguished in the structure of ecological competence: ecological knowledge and skills, ecological thinking, value orientations, and ecologically justifiable behavior. It is emphasized that the effective formation of younger schoolchildren's environmental competence is facilitated by means of nature itself, one of which is an ecological trail. Its purpose is to ensure the education of ecologically competent behavior of the child in the surrounding natural environment and to spread knowledge about nature and man as an integral part of the environment. The purpose, tasks, functions, and role of the educational ecological path in the education of ecologically competent behavior of the child in the environment are determined, and a brief description of the route of the ecological trail is presented. The potential of the means of the ecological path in the formation of ecological competence of children of primary school age has been analyzed. Attention is focused on the aesthetic value of the eco-path, which consists in activating the aesthetic feelings and experiences of younger schoolchildren while observing natural objects. It was found that the most productive direction of work on the ecological path is a practical excursion, the main types of activities of which are working out practical work, observation, project, research, sports and recreation, and game and creative activities.
CONTEMPORARY BLENDED LEARNING BACKGROUNDS OF TEACHING ENGLISH FOR LAW ENFORCEMENT
Authors: Loputko O. , Bohutskyi V. , Romanov I.
Published: April 2023

The article is devoted to the implementation of contemporary blended learning backgrounds into teaching English for specific purposes in the higher educational establishments of the Ministry of Internal Affairs of Ukraine. The analysis of the method’s usage in the special conditions of the war state is introduced. It is underlined that the implementation of such kind of technology will benefit not only the possibility to hold an educational process in the distant form in stressful conditions but also give the opportunity to the formation of a specific discipline’s knowledge using inter­disciplinary ways, to support the skills and abilities of the active self and group work.

The contemporary background of using blended learning technology is worked out in the paper. Special attention is paid to the respectful points of the international language learning centers that work in the sphere of new technologies implemented into teaching English in higher educational establishments. The peculiarities of the special cadets and officers’ regimes of study and daily routine are analyzed, and their advantages and disadvantages for the organization of the educational process are implemented in the process of the model’s building. Many possibilities to make the model flexible with the help of supporting the educational process through the different structural elements and units of the educational establishment are introduced. Active participation and correlation of all the members of the educational process on each level of the model’s organization are considered to be the central idea of the study. The organization of interdisciplinary events and the realization of creative and scientific directions of the educative work are also crucial for the successful realization of the model.
FEATURES OF THE PROFESSIONAL VOCALIST TRAINING IN THE CONDITIONS OF DISTANCE EDUCATION
Authors: Derda I.
Published: April 2023

We study the use of information technologies in the course of vocalist training under the conditions of distance learning. It is noted that the aim of all educational services is to create a unified educational environment with the association of teachers and students. Attention is paid to the fact that distance learning in music education facilitates the learning process, provides quick access to information, and encourages the vocalist to prepare and engage in creative activities in the classroom and independently.

The article analyzes the platforms for conducting online classes and organizing video and audio conferences at music education institutions in Ukraine, which, in particular, are used by teachers during vocal classes at the Department of Music of the Yuri Fedkovych National University of Chernivtsi. The method of using them is described in the example of such platforms as Zoom, Schoology, and Google Drive.

We consider information technologies of vocalist training in distance learning conditions.  They can be divided into online (real-time data exchange) and offline (storage and transmission of information on any electronic device of the addressee, for example, e-mail, video lecture recordings - Gmail, iCloud Mail, I.UA, UKR.NET, Outlook.com, Yahoo! Mail, Zoho Mail, AIM Mail, Inbox.com, ProtonMail, etc.). Offline technologies are effective for organizing consultations, conducting routine monitoring, and checking homework.

It is noted that the COVID-19 pandemic and the outbreak of war by the Russian Federation on the territory of Ukraine have changed the educational process in music education institutions – classes have largely moved from classrooms to online forms. In particular, the most common form of distance learning is a video conferencing platform that provides online communication in the classroom, screen demonstration with sound, video, and audio communication between vocalists and teachers, recordings of the video conference, interactive whiteboard, and administration. The purpose of online services is to provide communication and feedback to all participants in the educational process. The following services and applications are available for collective calls and conferences: Zoom, Google Meet, Google Classroom, Google Hangouts, Moodle, Discord, Skype, Viber, Telegram, etc.

It is established that a high level of information competence of a teacher ensures the effective use of information technologies in the course of vocalist training. Therefore, it is a necessary prerequisite for further improvement of their professional competence and one of the most important indicators of the success of activities. It determines the prospect of further research.
Los sectores económicos-sociales y la contaminación del aire en Perú, 1970-2020
Authors: Guevara Mamani Marcial , Calcina Álvarez Dominga Asunción , Huarca Flores Paola , Marca Flores Omar Henry , Ramirez Benavides Carmen , Ancco Torres Rocio
Published: April 2023

La contaminación del aire en estos tiempos está calificada como uno de los problemas ambientales más críticos y preocupantes a nivel mundial, debido a que rompe el equilibrio del aire, modificando la proporción de sus componentes o la introducción en la atmósfera de elementos tóxicos o indeseables que finalmente repercute en la calidad ambiental del entorno. El objetivo del estudio es determinar los sectores económicos y sociales que contribuyen hacia una mayor contaminación del aire en Perú, entre los periodos 1970-2020. Metodológicamente el enfoque fue cuantitativo, tipo analítico descriptivo y no experimental; se utilizaron los datos estadísticos de la base de datos del Instituto Nacional de Estadística e Informática, Banco Central de Reserva del Perú y de la página Datos-Macro, considerando el modelo econométrico de tipo log - log. Se determinó que los sector económicos y sociales que influyeron en la contaminación del aire son la densidad poblacional, el parque automotor, la producción de los sectores agropecuario, construcción y energía. Específicamente, el parque automotor, la producción de los sectores agropecuario, construcción y energía influyeron de manera directa en la contaminación del aire, mientras que la densidad poblacional influye de manera indirecta. Finalmente, ante un incremento en 1% en la producción de los sectores construcción, agropecuario y energía y del parque automotor, la contaminación del aire aumenta en 0.29%, 0.098%, 0.24%, 0.19% respectivamente; con respecto a la densidad poblacional, si incrementa en 1%, la contaminación del aire disminuye en 0.77%.
Dİagnostİc and Prognostic Significance of Inflammatory Parameters in Diverticular Disease of the Colon
Authors: HARMANTEPE Ahmet Tarık , DİKİCİER Enis , GÖNÜLLÜ Emre , CAPOGLU Recayi , YILDIRIM Atik , GULİYEVA Ulviyya
Published: April 2023

Aim
The aim of this study was to determine the presence of inflammation in asymptomatic diverticular disease using inflammatory parameters and to evaluate the relationship between inflammatory parameters and the degree of complication in symptomatic diverticular diseases.
Material and Method
Clinical and dermographic findings of patients with acute diverticulitis, patients with diverticulosis and healthy volunteers were compared.
Results
A healthy control group of 31 people, 40 patients with diverticulosis and 32 patients with acute diverticulitis were included in the study. Thirty-one (43.11%) patients were female and 41 (56.9%) male. RDW and MLR were significantly higher in patients with asymptomatic diverticulosis compared to the control group (p=0.02, p=0.00, respectively). NLR and SII were significantly different among Hinchey groups (p<0.01, p<0.01, respectively).Conclusion
We concluded that there may be a mild inflammation in asymptomatic diverticulosis patients, and NLR and SII can provide information about the degree of acute diverticulitis.
Keywords diverticulosis, inflammation, acute diverticulitis
The Impact of Partial Lockdown During COVID-19 Pandemic on Metabolic Control in People with Type 2 Diabetes Mellitus
Authors: TOKAÇ Ayşe Zülal , UĞUR Tuğde Buse , KURUGÖL Buse Ecem , ALİGÜLÜ Sevilay , HAYRAN Osman
Published: April 2023

Objective: In this study, it was aimed to determine the effects of lockdown due to COVID-19 on the metabolic control in people with type 2 diabetes mellitus.
Methods: This cross-sectional study (Ecological trend study) was conducted based on the medical records of patients with type 2 diabetes between September 20, 2019 and September 20, 2020. The metabolic control changes were evaluated as differences of haemoglobin A1c (HbA1c), fasting plasma glucose (FPG), creatinine (Cr), fasting triglyceride (FTG) and low-density lipoprotein-cholesterol (LDL-C) values during pre-lockdown and lockdown periods. The stratified analysis based on age (due to partial closure measures applied over the age of 65) and gender was also performed.
Results: There are statistically significant increases between FPG levels and FTG levels in the “during lockdown” group compared to the “pre-lockdown” group (p=0.036 and p=0.013 respectively) while the differences between HbA1c, LDL, cholesterol and creatinine levels are not significant. In subgroup analysis, increases in FPG and FTG levels remained in both <65 years and male groups, but no significant difference in any parameter was found in both ≥65 years and female groups.
Conclusion: COVID-19 partial lockdown period negatively impacts metabolic control in people with T2DM according to our study results. Although FPG significantly increased, this increase was not found in HbA1c levels. The worsening was more pronounced in the males and patients <65 years than in females and patients ≥ 65 years possibly because of major changes in lifestyle due to partial lockdown measures conducted in Turkey.
Direitos e limitações à liberdade de expressão na era digital
Authors: De Sousa Francisco de Sales
Published: April 2023

O presente estudo de revisão bibliográfica, tem o escopo de compreender a relevância das questões sobre os "Direitos e Limitações à liberdade de Expressão na Era Digital". Na primeira parte, uma investigação sucinta sobre a história e evolução dos meios de comunicação e a sua relação com a sociedade. Na segunda parte, uma reflexão sobre as leis existentes que garantem e limitam a liberdade de expressão e de manifestação de pensamento e suas implicações nas esferas penal e civil. Com isso não se pretende oferecer respostas definitivas sobre o tema, mas sim trazer elementos que possam contribuir para a discussão sobre o uso das tecnologias como forma de emancipação na sociedade atual.
Análise da eficácia do uso terapêutico da trimetazidina nas principais síndromes coronarianas agudas
Authors: Souza Marcos Vijano da Silva , Pacheco Luyla Oliveira Paes Landim , De Freitas Júnior Wellington Ubaldino , Guterres Maria Eduarda Mendes , De Almeida André Lucas Barros Damasceno , Mendes Filho Kleber de Jesus Serrão , Mendes Neto Pedro Cunha , Fonseca Leonardo Alencar Barros , Arouche Rodrigo Borges , Silva Fábio Augusto Oliveira do Carmo , Marques Katherynne Bezerra , Cantanhede Ana Beatriz Santos , Rocha Vítor Esdras Pinheiro Correia , Castôr Karoline Sampaio , Silva Júnior Robson Waldeck , De Freitas Luca Ferreira , De Oliveira Isabele Arruda , Alves Tatianne de Sousa , Bogéa Bruna Costa de Albuquerque , Furtado Poliana da Silva Rêgo , Braga Robertha de Cássia Cavalcante Dias , Castro Christian Ribeiro , Santos João Manoel Almeida , Cavalcante Adriana Valéria Gomes , De Brito Letícia Sá , Gonçalves Larissa Terra , Castro Jonathan Barbosa , Da Silva Amanda Alves Cardoso , Barcelos Pollyana Corrêa , Portela Camylla Mesquita , Costa Déborah Braga , Ferraz Renato Ezon Melo , Da Silva Tácio Tenório
Published: April 2023

A injúria de reperfusão, ou isquemia, é um mecanismo fisiopatológico que ocorre nas etiopatogenias do miocárdio, como na angina instável. Assim, são utilizados fármacos adjuvantes citoprotetores, como a trimetazidina (TMZ), que visam à diminuição do tempo de hospitalização e melhora na função cardíaca com ação profilática contra essa lesão. No entanto, apesar dos seus potenciais benefícios no tratamento da síndrome coronariana aguda, ainda não está clara a sua eficácia em relação a outras terapias disponíveis. Nesse sentido, o objetivo do estudo é analisar a eficácia do uso terapêutico da trimetazidina nas principais síndromes coronarianas agudas. Foi realizada uma revisão sistemática usando as bases de dados PubMed, Cochrane Library e Embase. Um total de 3 estudos foi incluído na análise. Os resultados mostraram que a terapia com trimetazidina reduziu significativamente a incidência de eventos cardíacos adversos maiores (ECAM) (OR = 0,33, IC 95% 0,15-0,75, p = 0,007), menor dano miocárdico (p < 0,05) e fração de ejeção ventricular esquerda mais elevada e menos eventos adversos em comparação com o grupo placebo (p < 0,05). Não foram observadas diferenças significativas entre os grupos de trimetazidina e controle em termos de mortalidade por todas as causas, mortalidade cardiovascular ou incidência de eventos adversos. Os resultados deste estudo sugerem que a terapia adjuvante com trimetazidina pode melhorar os resultados clínicos e a função cardíaca em pacientes com IAM sem aumentar o risco de eventos adversos. No entanto, são necessários mais ensaios clínicos randomizados em larga escala para confirmar esses resultados e determinar a duração e dose ideais da terapia com trimetazidina nessa população de pacientes.
Radioatividade: experienciação de uma sequência didática em um pré-vestibular social da cidade do Rio de Janeiro
Authors: Braga Bruno Matassoli , Rocha Angela Sanches
Published: April 2023

The 20th and 21st centuries are marked by the great number of technological advances in different areas of society. It is possible observe that equipment, procedures and technological systems become obsolete with almost the same speed and facility in which were implemented. It is from this great change, that appear questions about the role of education, especially regarding science teaching, to make a population more critical and participatory that could make its decisions in the globalized world. From this point of view, traditional teaching no longer meets the demand in the teaching-learning process, consequently changes are needs to perform a critical debate on science with the large population in a more inclusive way. In order to contribute to improve the teaching of Chemistry, the present work consists of the elaboration of a didactic sequence (DS) on Radioactivity and application of this in a social preparatory course. Audiovisual resources and texts were used to direct the DS, under the aspect of the significant learning methodology, with emphasis on the social role of science teaching. The approach was guided by documentaries about the accident that occurred in Goiânia with the radioactive material Césio-137 in 1987, which emphasizes the social and environmental consequences of non-understanding in the manipulation of radioactive materials. Debates were also used as a pedagogical tool in the formation of students as a critical individual and active participant in society. The results indicated that students felt motivated to learn the subject and actively participate in the class, making them more aware of the importance of science learning, emphasizing that this knowledge is not unique and important only for people who are or will specialize in the area.