bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementing the Competence Approach into the School Projects in Primary Grades
Authors:   Plovdiv University “Paisii Hilendarski”, Atanasova Nikolinka
Published: October 2023

The article examines students’ key skills necessary for an independent development of a pedagogical situation in Bulgarian in the kindergarten. It is indicated that the successful execution of this task largely depends on the ability of the students to get familiar with the content of the educational documentation, to properly prepare informational materials related to the educational work and to communicate with the parents. The combination of knowledge, skills and attitudes that fall within the framework of the competence approach, engaging the students with an active role in the educational process, is analysed. An exemplary framework is set regarding the essential methodical elements, necessary for the successful development of a pedagogical situation in Bulgarian and literature, which assists future teachers in their practical work and boosts their confidence when participating in current and state practice.
Education for Sustainable Development with Active Learning Methods in Primary Grades
Authors:   Sofia University, Bazan Maximiliyana
Published: October 2023

The current study presents the results of an experimental study implemented within the framework of a larger scientific work. The focus is on the dynamics in the knowledge and attitude of third and fourth grade students towards sustainable development within one academic year, through work with and without the author's didactic versions of short lessons related to the topics of sustainable development and based on methods and techniques for active learning. Participants in the study are 382 third- and fourth-grade students from different settlements in Bulgaria, divided into a control and an experimental group. The measurement was carried out using a proven author's methodology in the form of a questionnaire. The results testify that the systematic work with the proposed didactic versions leads to an increase in indicators in both dimensions under investigation. The described mathematical-statistical procedures confirm that the obtained results are not accidental, but are due to the applied experimental activity
Effects of the German Dual System and the Bulgarian Traditional System of Vocational Education on the Adolescents’ Personality: A Comparative Analysis
Authors: Asenova Ivanka , Soleva Maria
Published: October 2023

The article presents the results of a longitudinal study aiming to investigate the effects of the type of educational system on the personality of Bulgarian students in the period of late adolescence. Using the adapted Bulgarian versions of three self-assessment tests: the Heubeck и Neill psychological wellbeing scale, the Rosenberg self-esteem scale, and the the Eysenck mental states test, two groups of 32 adolescent students each, were examined at the beginning, at the middle of the second year and at the end of the third year of their education at two different vocational schools applying different educational systems: the German dual educational system, and the Bulgarian traditional vocational educational system, respectively. The results showed statistically significant between-group differences in the mean group scores on the studied personality characteristics. The results were analysed in the context of the impact of schooling on the personality development of young.
Study of the development of milkfish (Chanos-chanos sp.) cultivation based on plankton aspects
Authors: Patang
Published: October 2023

Background: Mandalle Beach, Pangkep Regency, is located in a coastal area with areas consisting of beaches, river estuaries, mangrove forests, rice fields, ponds, and residential areas. This area has potential for fish cultivation, especially milkfish cultivation. To support data and information about the prospects for cultivating milkfish in this region, a study was carried out on biological aspects, especially plankton. Materials and Methods: The research was carried out at five research locations, namely: location 1 is on the coast, which borders the coast of Barru Regency; location 2 is the location around the Pangkep State Agricultural Polytechnic Campus Pier; location 3 is on the beach, where mangrove vegetation grows around it; location 4, namely at the mouth of the river, which borders Mandalle Village and Tamarupa Village; and location 5, namely in the part adjacent to the rice fields and ponds of Mandalle Village. The plankton parameters tested were plankton abundance, variety, and dominance. The data obtained was then processed and analyzed using descriptive analysis. The plankton parameters tested were abundance, uniformity, diversity, and plankton dominance. The data obtained was then processed and analyzed using descriptive analysis. Results: The results showed that plankton abundance (cells/ml) was in the range of 250–300 cells/ml. Each research location has different types of plankton, which have the highest abundance. The plankton uniformity index value is in the range of 0.18108–0.22653, with the highest uniformity value occurring at location 2 and the lowest at location 3. The types of plankton that dominate in each research location are Chaetoceros sp., Gyrodinium sp., Thallasionema sp., Gymnodinium, and Cosconodiscus, but the most dominant type of plankton in all research locations is Chaetoceros sp., namely 0.461538462. Conclusions: Based on the study of the type, abundance, diversity, uniformity, and dominance of plankton, it can be stated that, based on the plankton aspect, the waters of Mandalle Beach, Pangkep Regency, are suitable and meet the requirements for cultivating milkfish; however, due to the large number of fishing activities and the proximity of residential areas and rice fields, the cultivation technique What is recommended is traditional or semi-intensive milkfish cultivation.
Origin of Hydrothermal Barite in Polymetallic Veins and Carbonate-Hosted Deposits of the Cyclades Continental Back Arc
Authors: Wind Sandra C. , Hannington Mark D. , Schneider David A. , Fietzke Jan , Kilias Stephanos P. , Bruce Gemmell J.
Published: October 2023

Polymetallic veins and breccias and carbonate-replacement ore deposits in the Cyclades continental back arc, Greece, formed from a range of fluid and metal sources strongly influenced by the dynamics of the late Mesozoic-Cenozoic Hellenic subduction system. These complexities are recorded in the isotopic signatures of hydrothermal barite. We investigated 17 mineral occurrences on four Cycladic islands and from Lavrion on the mainland. Here, barite occurs in almost all deposit types of Miocene to Quaternary age. We used a multiple isotope and geochemical approach to characterize the barite in each deposit, including mineral separate analysis of δ34S and δ18O and laser ablation-inductively coupled plasma-mass spectrometry of 87Sr/86Sr and δ34S. Barite from carbonate-hosted vein and breccia Pb-Zn-Ag mineralization on Lavrion has a wide range of δ34S (2–20‰) and δ18O (10–15‰) values, reflecting a mix of magmatic and surface-derived fluids that have exchanged with isotopically heavy oxygen in the carbonate host rock. Sulfur (δ34S = 10–13‰) and oxygen (δ18O = 9–13‰) values of barite from the carbonate-hosted vein iron and barite mineralization on Serifos are permissive of a magmatic sulfate component. Barite from epithermal base and/or precious metal deposits on Milos has δ34S (17–28‰) and δ18O (9–11‰) values that are similar to modern seawater. In contrast, barite from vein-type deposits on Antiparos and Mykonos has a wide range of δ34S (16–37‰) and δ18O (4–12‰) values, indicating a seawater sulfate source modified by mixing or equilibration of the hydrothermal fluids with the host rocks. Strontium isotope ratios of barite vary regionally, with 87Sr/86Sr ≥ 0.711 in the central Cyclades and 87Sr/86Sr ≤ 0.711 in the west Cyclades, confirming the strong influence of upper crustal rocks on the sources of fluids, Sr, and Ba in the formation of ore.
Trust-wide clinical neuropsychology peer supervision group: A service evaluation
Authors: Piper Charles , King Lorraine , Wall Gemma , Devenney Etain
Published: October 2023

This paper reports an evaluation of a monthly Trust-wide Clinical Neuropsychology peer supervision group set up in 2021 to respond to requests from clinicians for informal case discussions, whilst also providing group supervision for team members undertaking specialist Clinical Neuropsychology training. This evaluation was conducted to review how the group was received by attendees and facilitators, identify improvements, and address barriers to attendance. Group-specific questionnaires were completed by four facilitators and 21 participants. The findings suggested the group met its aims, and is consistent with many of the service and Trust aims and values. The majority of responses suggest the group has several benefits such as facilitating a space for reflection and exploring complex cases collaboratively. Both facilitators and participants felt their clinical practice was enhanced.
Developing an understanding of the Frontal Lobe Paradox through clinical group discussions
Authors: Copstick Sue , Turnbull Lorraine Bobbie , Tibbles Jennifer , Ashworth Sarah , Swanepoel Henk J. , Kinch Julianne , Moffitt Jenna
Published: October 2023

This discussion paper presents reflections from a group of clinical, forensic and neuropsychologists on their clinical caseloads in brain injury rehabilitation services at Cygnet Healthcare. These services specialise in working with people with coexisting mental health or behavioural difficulties where the work involves frequent staff discussions on interpreting an individual’s behaviour, considering its functions and whether it is part of an involuntary neuro-psychological disorder related to their brain injury, specifically the Frontal Lobe Paradox. Through consideration of six patients, the cognitive mechanisms that may relate to, or underlie apparent Frontal Lobe Paradox were highlighted. Several additional reasons were found to explain why people might show this paradox, including testing conditions, slowed processing, reduced attention, disinhibition, self-monitoring problems, and premorbid difficulties. The authors also discuss interventions, which could be used to support these individuals, with the aim of broadening clinical understanding and discussion surrounding the causes of, and treatment approaches for individuals presenting with potential Frontal Lobe Paradox.
EVALUATION OF FUNGICIDES AGAINST TURCIUM LEAF BLIGHT OF MAIZE CAUSED BY EXSEROHILUM TURCICUM
Authors: SHAH JA , KHAN MD , SHAH AUH , FATIMA I , FATIMA S , AHMED B , AKRAM M , SALEEM U , BATOOL Z , MAJEED T
Published: October 2023

Northern Leaf Blight of Maize (NLBM) is a serious disease of Maize crop in Pakistan. The disease causes heavy losses in maize crop every year. To avoid this loss, a research experiment was conducted to check the efficacy of four fungicides and one control against Turcicum Leaf Blight of maize. The experiment was tested against the maize variety Malka-2016. The trial was conducted at Research Area of Plant Pathology Research Institute, Faisalabad, from 2021 to 22. The result of experiment showed that DithaneM-45 (Mancozeb), Tilt 25%EC (propiconazole), Score 25% EC (Difenaconazole), and Topsin-M70%WP (Thiophenate Methyl) significantly reduced the northern leaf blight disease of Maize and increase the yield.  Dithane M45(Mancozeb) controlled the disease by 86% over control ,followed by Tilt (Propiconazole) by 79%, Score (Difenaconazole) by 71 %, and the least effective fungicide was Topsin-M 70% WP (Thiophenate Methyal) which control the disease by 68%.
NUTRIENT TRANSFORMATION THROUGH NANOFERTILIZERS IN SOIL
Authors: REHMAN HU , KAUSAR R , NAWAZ S , AKRAM F , ASIF M , ALI S , KAUSAR S , NADEEM M , IMRAN M , SARWAR MA
Published: October 2023

Global population growth during the past ten years has compelled the agricultural industry to boost crop yield to meet the requirements of billions of emerging nations. Widespread nutrient shortage in soil has caused a major nutritional value decline and substantial financial losses for farmers. Agriculture can only grow by using modern innovations wisely to raise output. The application of nanotechnology to plant science and agriculture has increased recently. The development of nanotechnology has made it easier to produce physiologically significant metal nanoparticles on a large scale. These nanoparticles are currently utilized to enhance fertilizers formulation for greater plant cell absorption and reducing nutrient loss. Ongoing study provides a fresh impression of nanoparticles (NPs) biosynthesis, their use as nano-fertilizers and nano-pesticides, their application in agriculture, and their contribution to improving the performance of bio factors. An overview of NPs-plant interactions, the destiny and fate of nanomaterials in plants, and the role of NPs in reducing the negative impacts of toxicity and stress has been provided. The information in the current review paper is essential for identifying the restrictions and potential uses of nano-fertilizers as a replacement for traditional fertilizers in the future.
Occurrence of multiple albino seedlings in Madhuca balakrishnanii (Sapotaceae): An endemic species of the Western Ghats in India
Authors: Anusha Panthalattu , Nithyamol Kanjitharayil , Joseph Rejitha , Shylajakumari Sreedharan , Shareef Sainudeen , Kumar Ettickal Sukumaran
Published: October 2023

This paper discusses the occurrence of multiple albino seedlings for the first time in Madhuca balakrishnanii E.S.S.Kumar et al. (Sapotaceae), a critically endangered and endemic tree species of southern Western Ghats.
Effects of dietary mannan oligosaccharides and coated calcium butyrate on performance, carcass parameters, blood biochemistry and meat quality of growing Japanese quails
Authors: GUMUS Erinc , SEVIM Behlul , OLGUN Osman , KUCUKERSAN Seher
Published: October 2023

Aim of study: Despite previous research into mannan oligosaccharides (MOS) and calcium butyrate coated with palm oil (CCB) in poultry, there is a notable gap in the literature regarding the effects of these feed additives, either individually or in combination, on the growth performance, carcass values, blood biochemistry, immune response, and meat quality of growing Japanese quails.
Area of study: Türkiye
Material and methods: A total of 168 mixed-sex one-day-old quails were randomly allocated to one of four treatment groups, with each group containing 7 birds per cage. The control group was fed a basal diet, while the treatment groups received the following additives: 1 g/kg of CCB, 2 g/kg of MOS, and a combination of MOS+CCB added to the basal diet, respectively.
Main results: None of the treatments had a significant impact on performance, relative organ weights, total protein, albumin, globulin, total cholesterol, high-density lipoprotein cholesterol, and lipoprotein lipase concentrations in blood serum, or humoral immunity on day 28. However, the inclusion of MOS and CCB in the diet, either individually or in combination, increased carcass yield and reduced low-density lipoprotein cholesterol and triglyceride levels in the blood serum. Additionally, these additives helped maintain optimal pH levels and lower malondialdehyde concentrations in the breast meat. Moreover, the combination of MOS + CCB significantly improved water holding capacity and antibody titers against the Newcastle Disease vaccine on day 42 in Japanese quails.
Research highlights: The natural feed additives CCB and MOS contribute to enhanced carcass yield, improved meat quality, and strengthened humoral immunity, while simultaneously lowering lipid values in the bloodstream.
Analisis Perilaku Penyeberang Pejalan Kaki Di Zebra Cross Jalan Pemuda Kecamatan Kolaka Kabupaten Kolaka (Studi Kasus Depan SMP Negeri 1 Kolaka)
Authors: Laode Al Tafakur , Rustan Fathur Rahman , Masgode Muhammad Buttomi , Santoso Heri , Dzakir La Ode
Published: October 2023

Pejalan kaki memiliki hak yang sama dengan pemakai jalan lainnya pengendara motor atau mobil yang kerap kali pejalan kaki menjadi korban pengendara lain yang merasa superior. Berdasarkan dengan keselamatan pejalan kaki terutama di lingkungan sekolah, lokasi studi adalah Zebra Cross akses jalan SMP Negeri 1 Kolaka yang terletak di jalan Pemuda, lokasi tersebut dipilih dikarenakan berada di jalan arteri primer yang masuk wilayah perkotaan dan jalan nasional sehingga keberadaan Zebra Cross terhadap lalu lintas kendaraan dianggap sangat penting. Penelitian ini bertujuan untuk mengetahui perilaku dan persepsi penyeberang jalan pada Zebra Cross di jalan pemuda depan SMP Negeri 1 Kolaka. Hasil penelitian ini menunjukkan pada waktu jam masuk dan jam pulang sekolah, untuk perilaku penyeberang SMP Negeri 1 Kolaka yang menyeberang melalui Zebra Cross lebih sedikit di bandingkan dengan penyeberang di luar Zebra Cross, waktu rata-rata penyeberang jalan yaitu 6,88 detik/ 88 orang, jumlah kendaraan pada jam masuk sekolah dari dua arah sebanyak 11.219 kendaraan/minggu dan pada jam pulang sekolah dari dua arah sebanyak 11.380 kendaraan/minggu. Sedangkan untuk persepsi penyeberang jalan dari 88 responden mengatakan pemahaman tentang Zebra Cross 81,81% mengatakan tahu, keamanan menyeberang di Zebra Cross 88,64% merasa aman, sosilalisasi tentang Zebra Cross 7,95%, pernah mengikuti sosialisasi, 92,05% merasa tidak pernah mengikuti sosialisasi, faktor sulitnya menyeberang di Zebra Cross 64,77% mengatakan kendaraan terlalu padat dan kencang, 12,5% merasa pandangan terhalang terhadap parkir liar dan pedagang kaki lima, 22,73% megatakan jarak terlalu jauh, fasilitas pejalan kaki di Zebra Cross 51,14% mengatakan cukup, belum memadai 40,91% dan ditambahkan jembatan penyeberangan 7,95%.
Studi Karakteristik Marshall Pada Campuran Lapis Aspal Beton (Laston) dengan Bahan Tambah Limbah Kain Nilon
Authors: Yusnianti Yusnianti , Sufrianto Sufrianto , Hujiyanto Hujiyanto , Syamsuddin Syamsuddin
Published: October 2023

The use of nylon fabric waste as adding material for concrete asphalt layers can be one of the solutions, because it can reduce pollution in the environment.The level of variation in adding nylon fabric waste is 0%, 5%, 10% and 15%. Sample testing as many as 24 test specimens. . The purpose of this study is to determine the physical properties of the asphalt with the added material of the nylon fabric waste and to determine the properties of the concrete asphalt layer mixture (Laston) with the added material of the nylon fabric waste. The results of testing the addition of nylon fabric waste levels as added material to the asphalt show that the value of the physical properties of asphalt is penetration, soft point, specific gravity, flame point and fuel point and asphalt dactality meets the standard specifications of the 2018 SNI Marga. As well as the addition of nylon substitution waste a number of asphalt at 5%, 10% and 15% content can affect the nature of concrete asphalt layers (Laston). In variations of 5%, 10% and 15% density value of 2,336 gr/cm, 2,327 gr/cm, 2,343 gr/cm, stability of 1892,4 kg, 2239,0 kg, 1953,6 kg, VMA of 15,9%, 16,2%, 15,6%, VIM of 4,4%, 4,7%, 4,1%, VFB of 73,6%, 70,9%, 74,0%, melting of 3,93 mm, 3,43 mm, 3,02 mm and MQ of 480,1 kg/mm, 652,9 kg/mm, 691,5 kg/mm.
International Journal of Higher Education, Vol. 12, No. 5, October 2023 (Special Issue)
Authors: Sun Susan
Published: October 2023

International Journal of Higher Education, Vol. 12, No. 5, October 2023 (Special Issue)
Trends in the Development of Choreographic Education in Ukraine in Conditions of Digitalization: Standards, Innovative Models
Authors: Bigus Olga , Chepalov Oleksandr , Herts Iryna , Mova Liudmyla , Khotsianovska Liudmyla , Babych Olha
Published: October 2023

The aim of this work is to analyze the trends in the development of choreographic education in Ukraine in the context of digitalization, as well as to identify standards and innovative models for further development. Scientific methods of analysis, synthesis, and deduction were used to study the mentioned problems. The results demonstrated the current standards of training of choreographers in Ukraine, the peculiarities of the implementation of digitalization, and its impact on innovative methods of teaching choreography. The importance of using the European experience in the formation of cooperation between educational institutions and potential employers has been proved. The indicated borrowing of experience will make it possible to adapt the Ukrainian training conditions of choreographers to modern educational trends, harmonize individual stages of training and generally increase its level, quality and balance. In Ukraine, the unique approach to innovative choreographer training lies in imparting a diverse range of combinations, predominantly showcasing Ukrainian choreographic displays enriched with a harmonious blend of European traditions. The conclusions noted that further relevant trend of innovative development of choreography education in Ukraine will be attempts to harmonize the Ukrainian and European training systems.
Development of Higher Education of the XXI Century in the World Context in the Face of Global Challenges
Authors: Hrechanyk Nataliia , Vasiuk Oksana , Matsenko Lesya , Folomieieva Nataliia , Koriakin Oleksii , Vyhovska Svitlana
Published: October 2023

The article is devoted to the problem of higher education development in the twenty-first century in the context of global challenges. Since the scientific research did not include an empirical component, theoretical methods of scientific knowledge (analysis, synthesis, abstraction, etc.) became additional components of the methodological toolkit, and the analysis of relevant scientific publications on educational issues for the period of 2019-2023 was taken as a basis. For convenience, the materials were systematized according to the relevant topics: development and implementation of innovative methodology in the educational process; opportunities for integrating digital technologies into education, digitalization; stakeholder requirements for the personality of a specialist and their implementation in the educational process; problems and prospects for the development of the educational sector; transformation of higher education in Ukraine under the influence of a full-scale war. The purpose of the article was to analyze certain aspects of the development of higher education in the twenty-first century. The analysis of publications allowed us to identify visions of ways to solve educational problems and modernize higher education. Particular attention was paid to the peculiarities of the organization of higher education in Ukraine during the war and the factors that will stimulate/hinder the development of post-war Ukrainian higher education. The generalization of information obtained from relevant scientific sources made it possible to model the process of transformation of higher education today, to identify global factors, to point out the incentives and the path of development that the educational sector is currently moving along. The novelty of the proposed research lies in the attempt to systematize existing scientific studies and build a holistic vision of the transformation processes in higher education. The article is aimed at educators, students, educational reformers, and researchers and aims to draw attention to the importance of educational issues.
Implementasi Pendidikan Karakter Berbasis Imtaq di SMP A. Wahid Hasyim Tebuireng Jombang
Authors: A'yun Kurroti , Khomariyah Siti , Khudriyah Khudriyah
Published: October 2023

The future challenge in education is creating individuals who are able to learn for life. The challenge of shifting values ??in society will bring a value crisis. To avoid it is implementing of character education to improve the quality of faith and piety. This study aims to describe the implementation of character education. This research is a qualitative research. Using interview, observation, and documentation as techniques of collecting data, then the data was analyzed by Miles and Huberman models. The research results showed that the implementation of character education through: habitual worship before school, in the class, rest, and before going home; giving advice inside and outside the learning process; exemplary teacher in starting the application of character education; internalization by focusing on cognition dimension and value, as well as extracurricular and religious programs. The character values ??applied are: sincerity, honesty, responsibility, hard work, and tasammuh.
Design of Solar Thermal Injera Baking System Using Nanofluid as Heat Transfer Fluid
Authors: Yohannis Eyosiyas
Published: October 2023

Solar energy is one of the most promising renewable energy sources since it is free, available at all locations, and non-polluting. During the traditional biomass Injera baking process kitchen environment is highly polluted with soot and smoke that affect the health of household inhabitants. In addition to that, it will highly contribute to climate change. The source for fuel wood is forest and due to deforestation, desertification and soil degradation will happen. The use of solar energy with nanofluid can enhance the system efficiency and remove all problems mentioned above. On this article solar thermal injera baking system by using nanofluid as heat transfer media is designed. Total amount of energy required for a single baking period is  by considering average family size of five and each will consume three injera per day the total amount of injera required per day is 15 injera, for three days 45 injera. From the design process it was observed that the use of nanofluid reduce the size of commoponanats when we compare with other types of conventional fluids. The use of nanofluid for the solar thermal injera baking method reduces the time required for the baking process.
pandemic process in children
Authors: enol Ferda , eci ilkay , Babacan Altay , Arslan Nuray , Toraman Zulal
Published: October 2023

Aim: When compared to adults, it is seen that the COVID-19 disease in children has a milder course. However, considering that there are cases with severe course and even death, it is aimed to analyze the COVID-19 PCR positivity in children according to age and gender.
Materials and Methods: Between March 7, 2020 and August 18, 2021, throat and nose swab samples from children with clinical complaints or a history of contact were evaluated by reverse transcriptase polymerase chain reaction (RT-PCR) and the distribution of positive children by age and gender classified.
Results: The PCR test was positive in 3,181 (30.74%) out of 10,342 children, the highest positivity rate was 33.52% in male and in the 15-18 age range, while this rate was 36.77% in female in the 15-18 age range.
Conclusion: In this study, it was determined that the prevalence of the COVID19 pandemic, which affected the whole world, in childhood age groups was highest in male and between the ages of 15-18.
Cervical Sagittal Curvatures Of Workers In The Textile Industry
Authors: z Abdullah , n Ayd , nc Cevat , er Melih
Published: October 2023

Objective: Workers in the textile industry commonly use their upper extremities, and neck while working . The prevalence of neck and arm pain among workers in the textile industry is well understood. Impaired cervical lordosis is associated with pain and functional disability. Scientific studies have rarely focused on anatomical foundations. Our aim of the study is to measure the cervical lordosis angles (Cobb C2-7) of workers working in the textile industry.
Materials and Methods: Our study is a single-center, non-randomized, retrospective, and observational. Demographic information, clinical and radiological images were analyzed hospital records. Recorded visual analog scale, neck pain, arm pain, and sensory problems were examined hospital records. “Cobb 2-7” angles were measured by a single physician with the program called “Akgün”, which is the electronic database program used by the hospital.
Results: We detected a total of 53 textile workers. 33 (62,26%) were female and 20 (37,73%) were male. All of the cases gave a history of working position with their neck flexion. The demographic information of the patients is shown in the table. The average of the Cobb 2-7 angles of the cases was measured as -6.43±12.17
Conclusion: Textile workers commonly have neck pain. we detected deterioration in the cervical alignment of textile workers. We attribute the cause of neck pain in textile workers to the flexion position of the neck. We think that the continuous neck flexion position impairs cervical lordosis. Further prospective and high-quality studies are needed.
THE INVESTIGATION OF LIPOPROTEIN-RELATED PHOSFOLIPASE A2 (LP-PLA2) V279F MUTATION IN CORONARY ARTERY DISEASE
Authors: LU Hatice , ER Nazl , SUNGUR Mehmet , YILMAZ Dilek , TAMER L
Published: October 2023

Objective: Despite advances in the treatment of cardiovascular diseases, coronary artery disease (CAD) maintains to be the leading cause of death in many nations. The media layer of normal and diseased arteries contains lipoprotein-associated phospholipase A2 (Lp-PLA2), which is mostly made by mast, T lymphocytes, and monocytes. Our research sought to define how the Lp-PLA2 and V279F gene polymorphisms relate to CAD.
Materials and Methods: This study included 71 controls and 109 patients. Fasting blood glucose (FBG) and lipid profiles, were measured the enzymatic colorimetric technique. Lp-PLA2 levels were detected with ELISA. The genomic DNAs were isolated from whole blood. Real-time polymerase chain reaction (RT-PCR) with the V279F mutation detection kit was used to identify the Lp-PLA2 V279F mutation.
Results: In the CAD compared to the controls, serum Lp-PLA2 levels were higher (p 0.001). While FF (mutant) genotypes and VF (heterozygous) genotypes were absent from both groups, the Lp-PLA2 V279F mutation was discovered as the VV (wild) genotype in both control and CAD.
Conclusion: As a result, we determined that the Lp-PLA2 V279F mutation cannot be considered a genetic risk factor for CAD, but that Lp-PLA2 elevation may be an important parameter for CAD.
Serum hypoxia-inducible factor 1 alpha levels in stroke
Authors: ekli Esen , du Asl , Kotan Dilcan , zkan Asuman
Published: October 2023

Aim:
In order to survive, human cells must adapt to changes in the oxygen level of their environment. Many endogenous mechanisms operate in hypoxia. Hypoxia-inducible factor 1 (HIF-1) is a transcriptional protein involved in the head of the cascade that regulates the response of brain and other tissues to hypoxia. HIF-1 alpha (HIF-1α) is the main molecule that responds to hypoxia and is an important marker of cerebral hypoperfusion.
Materials and Methods:
39 acute stroke patients aged between 18-80 years and 38 control patients included in our study. We aimed to examine the serum HIF-1α levels in early period of acute ischemic stroke. We also aimed to evaluate its usefulness in determining tissue damage due to hypoxia and the prognosis of the disease.
Results:
Serum HIF-1α levels were higher in acute ischemic stroke patients compared to the control group (p= 0.000). There was no significant correlation between infarct volumes, NHISS scores, blood pressure and HIF-1α values of the stroke patients.
Conclusion:
HIF-1α could be an important biomarker in detecting cerebral hypoxia. It is possible to study this in human peripheral blood. Its usability in stroke may become widespread with studies on its therapeutic target.
The Evaluation of Dynamic Thiol/Disulfide Homeostasis in Papillary Thyroid Carcinoma
Authors: Akhanl P , en Sema , er Hakan , l Muhammed , lu Salim , Erel zcan , akal Erman
Published: October 2023

Objectives: Aim of this study is to analyze the correlation between thiol/disulfide homeostasis (TDH) and papillary thyroid carcinoma (PTCA) and to reveal the possible impact of TDH on the development of PTCA.
Material and Methods: Preoperative venous blood sampling was obtained from the patients having applied to our hospital due to euthyroid nodular goiter and detected with suspected malignancy or malignant cytology in FNAB, according to the BETHESDA system. Those whose postoperative histopathological results proved the presence of PTCA were involved in this study. Healthy volunteers who were without any thyroid nodules and thyroid dysfunction.
Results: The number of participants in the patient and control groups was 34 and 101, respectively. Compared to the control group, native thiol (μmol/L), total thiol (μmol/L), and native thiol/total thiol × 100 values were ascertained to be lower in the patient group with PTCA; however, these values were not statistically significant. Disulfide, disulfide/native thiol × 100, and disulfide/total thiol × 100 values were detected to be lower in the patient group with PTCA, but not statistically significant. When the patients with PTCA were assessed within themselves, TDH parameters were not associated with the PTCA subtype, the number of foci, the presence of lymphovascular invasion, and the presence of metastatic lap.
Conclusion: Considering the parameters of PTCA and TDH, the results were not statistically significant. And besides postoperative histopathological findings such as the PTCA subtype, the number of foci, the presence of lymphovascular invasion, and presence of metastatic lap were not correlated with THD parameters.
Opinions of Healthcare Professionals on Hand Hygiene Use and Evaluation of Hand Hygiene Compliance Rates
Authors: elik Mehmet , Ceylan Mehmet , lu G , Durna Meryem , Atasoy P , Alkan Sevil
Published: October 2023

Objective: The aim of this study was to determine the hand hygiene habits, beliefs, and practice levels of healthcare workers.
Materials and Methods: A total of 238 healthcare workers were included in this cross-sectional survey study. The first part of the questionnaire included sociodemographic data and questions about hand hygiene habits, while the second part included questions from the Hand Hygiene Belief Scale (HHBS) and Hand Hygiene Practice Inventory (HHPI).
Results: Results: The mean age of the participants was 33.16±8.54 years and 147 (61.8%) of them were male. The majority of the participants were nurses/health officers (n=92, 36.8%). The rate of those who had previously participated in in-service training was 58.4%. The mean HHBS score was 79.79 and the mean HHPI score was 60.08. The mean HHBS score was higher in women than in men (p=0.003). In terms of occupational groups, the mean HHBS score of physicians (p=0.024) and the mean HHPI score of nurses/health officers (p=0.006) were higher. It was determined that the mean HHPI score of the employees working in internal clinics was higher than those working in surgical clinics (p=0.044), while there was no significant difference in terms of the mean HHBS score. The mean HHPI was higher in participants who received in-service training on hand hygiene (p=0.004). Participants who spent <15 seconds on average while washing their hands had a lower mean HHPI than participants who spent a longer time washing their hands (p=0.003).
Conclusion: In the study, it was found that the belief in hand hygiene was high and the practice was generally adopted. The fact that employees especially in surgical departments paid less attention to hand hygiene practice was an important problem. Increasing the frequency of in-service pieces of training to increase compliance with hand hygiene and eliminating the preventive factors will be extremely beneficial for reducing nosocomial infections.
ECG changes in male patients with alcohol and methamphetamine use disorder: Can alcohol have an antiarrhythmic effect?
Authors: Aras Neriman , Yontar G
Published: October 2023

Background: Cardiac complications due to methamphetamine and alcohol play an important role in mortality.
Aims: This study aims to investigate ECG markers and possible arrhythmia risk in both patients with methamphetamine use disorder (MUD) and alcohol use disorder (AUD) and compared them with healthy controls.
Methods: The study included 26 patients with methamphetamine use disorder, 27 patients with alcohol use disorder, and gender, and age-matched controls (27 controls for MUD, and 28 controls for AUD). ECG measurements were obtained using the ImageJ program which is a reliable program that can be used to measure images in medicine. ECG parameters included heart rate, PR, QRS, and QT intervals, P and QT dispersion, QTc, Tp-e, Tp-e/QTc, and iCEB, a new biomarker for predicting drug-induced cardiac arrhythmias.
Results: All of the participants were men. The mean age of patients with MUD was 28.46±7.1, and AUD was 40.41±10.9. In both groups, most of the patients did not describe cardiac symptoms in the past (73.1% for MUD, and 66.7 for AUD). Patients with MUD and AUD had a higher mean heart rate than controls (p<0.005 and p<0.05, respectively). Mean heart rate was significantly higher in both patient groups than in controls. Sinus tachycardia was detected in 26.9% of patients with MUD, and 22.2% of AUD. In the MUD group, mean QTc values were longer than controls (p<0.001), and prolonged QTc interval was detected in 11.5% of patients. In the AUD group, the mean QT dispersion was shorter than controls (p<0.05).
Conclusion: Our data support the well-known previous data of methamphetamine and alcohol on the heart such as increased heart rate, tachycardia, QTc prolongation, and also the effectiveness of ECG in monitoring alcohol and methamphetamine-induced cardiac effects. Interestingly, it replicates previous data that alcohol may have antiarrhythmic effects through decreased mean QT dispersion.
The Role of Mean Platelet Volume/Platelet Count in Differentiation of Simple and Complex Febrile Seizures
Authors: r Bilge , k Serkan , cel g , karada meral
Published: October 2023

Background and Aim: Our study aimed to find the relationship between MPV (Mean Platelet Volume) levels, a marker of inflammation, and platelet counts between simple and complex febrile seizures.
Materials and Methods: In this retrospective comparative study, we analyzed the records of 283 children between the ages of 6 months and 6 years who were diagnosed with simple and complex febrile seizures (BFN/CFN) in the Pediatric Neurology Clinic of XXX University, Faculty of Medicine between January 2021 and December 2022.
Results: The mean age and gender characteristics of the patients were similar in both groups. The MPV of the CFN group (69 patients) (6.53±0.39fl) was lower than that of the BFN group (214 patients) (7.81±0.43fl) and this difference was statistically significant (p<0.01). The platelet count of the CFN group (257.42×103±126.01×103) was higher than that of the BFN group (191.23×103±68.29×103) and the difference was statistically significant (p<0.01).
Conclusion: There was a significant difference between BFN and CFN groups in terms of both MPV values and platelet counts. This study suggests that detailed and comprehensive studies on MPV and platelet counts may guide cases where clinical findings are suspicious and the distinction between BFN and CFN cannot be clearly differentiated.
Childhood Trauma And Emotion Regulation In Psoriazis Patients
Authors: L BEDR , ZAYMAN ESRA , SARA G
Published: October 2023

Aim: The aim of the present study was to determine if there is any relationship between childhood traumas, emotion regulation, depression, and anxiety with psoriasis severity; it also attempted to find out whether these factors affect the development of psoriasis.
Materials and Methods: This study enrolled 100 patients with psoriasis aged 18-65 years and 100 healthy volunteers who were free of any form of psychiatric treatment, active psychiatric symptoms, and dermatological diseases. Sociodemographic Data Form, Childhood Traumas Scale (CTS), Difficulties in Emotion Regulation Scale (DERS), Hamilton Anxiety Scale (HAM-A), and Hamilton Depression Scale (HAM-D) were filled by the study subjects.
Results: The patients and controls were compared with respect to HAM-D, HAM-A, CTS, and DERS scales. The patients had higher HAM-D, HAM-A, CTS Physical abuse, CTS Physical neglect CTS Emotional neglect, CTS Sexual abuse, CTS Total, DERS Clarity, DERS Impulse scores than the controls (Table 2) (p<0.001, p:0.011, p:0.021, p:0.005, p<0.001, p:0.045, p<0.001, p<0.001, respectively).
Conclusions: Psoriasis should be treated in collaboration of dermatology, psychiatry, immunology, rheumatology, and even medical pharmacology departments.
Inflammatory Biomarkers in Rosacea Patients
Authors: rok Ne
Published: October 2023

Aims: Rosacea is a chronic inflammatory skin disease characterized by telangiectasia, papules and pustules associated with immune response. Several factors, especially inflammatory factors, have been investigated in its etiopathogenesis. The Systemic Immune Inflammation Index (SII) is a novel inflammation marker. It has recently been used to evaluate the inflammatory and immune status of the patients. Also, several studies investigated other inflammation markers such as neutrophil/lymphocyte (NLR) and platelet/lymphocyte (PLR) ratios. The present study aims to investigate the correlation between rosacea, an inflammatory disease, and inflammatory markers such as platelet (PLT), lymphocyte (LYM), neutrophil (NEU), NLR, PLR, and especially SII.
Methods:The study was conducted with 100 papulopustular rosacea patients and 100 healthy controls. The patient and control groups were similar in age and gender. Participant data and laboratory results were obtained retrospectively from the patient files.
Results: Seventy-eight of the rosacea patients were female and 22 were male. The mean participant age was 47.97. There was no significant difference between rosacea patients and the control group based on age and gender. The PLT and LYM markers were significantly lower in the patient group when compared to the control group, and NLR, PLR and SII markers were significantly higher in the patient group (p<0.05).
Conclusion: The significant difference between the investigated inflammatory parameters suggested that rosacea could be a systemic inflammatory disease rather than a simple skin inflammation. More comprehensive studies are required to clarify this premise and the correlation between rosacea and systemic inflammation.
THE IMPORTANCE OF OBSTRUCTIVE SLEEP APNEA SCORE AND END-TIDAL CO2 LEVEL IN ADOLESCENT CHILDREN WHO UNDERWENT OROPHARYNGEAL SURGERY
Authors: zer Hayel , m lker , zl Tolga
Published: October 2023

Aim
Children with obstructive sleep apnea have an increased postoperative risk of adverse respiratory events. In our study, we calculated Obstructive Sleep Apnea Scores using the modified STOP-Bang questionnaire in children undergoing oropharyngeal surgery. The groups determined according to this score were compared in terms of mask ventilation levels in the intraoperative period, postoperative complications and postoperative ETCO2 levels.
Methods
A total of 90 patients, aged 7-15 years, who will undergo oropharyngeal surgery, classified as ASA I-II, and who have undergone a modified STOP-Bang questionnaire at the preoperative examination, were included in the study. Obstructive sleep apnea score (OSAs) was determined according to the modified STOP-Bang questionnaire, and the patients were divided into 3 groups as low, medium, and high-risk. Difficult mask ventilation level was noted in the intraoperative period. At the end of the operation, end-tidal carbon dioxide concentration (ETCO2) values at 0, 3, 5, 10, and 15 minutes after the patient was extubated and whether the patient had spasms were recorded.
Results
Among the 8 parameters in the modified STOP-Bang questionnaire, it was found that there was a significant difference between the groups for the other 6 parameters except for snoring and learning disability. Diffucult mask ventilation increased significantly from Group I to Group III. There is a significant difference between Group I and II, Group II and III, and Group I and Group III (p= 0.001). Although there were small differences within the groups and between the measurements of ETCO2 at different minutes, these differences were not statistically significant (p≥0.05)
Conclusion
In conclusion, associations between the results of the modified STOP-Bang questionnaire and the level of intervention required for difficult mask ventilation, this information could serve as a useful indicator for a higher level of care in the perioperative period for future patients
What is the best treatment for anemia in pregnant women in the third trimester: Ferric carboxymaltose or oral iron therapy?
Authors: Eren Elif , Karakurt Yakup , Sadri Sevil , Demirel Gamze
Published: October 2023

Objective: Iron deficiency anemia (IDA) is a significant health problem in pregnant women. We aimed to evaluate the effect of gestational IDA and to compare the results of iron therapy in pregnant women.

Methods: This retrospective cohort study of pregnant women in the third trimester analyzed the records of 63 women not taking any iron supplements, 70 women receiving intravenous ferric carboxymaltose therapy (FCM), and 73 pregnant women receiving oral iron therapy. It compared maternal and neonatal outcomes of the three groups.

Results: The mean age of the 206 pregnant women included in the study was 29.19±4.34 (19-44; min–max). Only 1% of anemic women received a blood transfusion in the postpartum period. There was no difference between the groups' mean age and gestational week. The median values of gravida and parity were the same in all 3 groups (Gravida=2, Parity=1). Maternal hemoglobin (Hb) value of the non-iron group was lower than that of the other groups (p<0.001). Although the mothers' Hb levels at birth were different, the newborns' Hb values were not affected (p=0.547). Neonatal height and weight were lower in the non-iron group than in the FCM and oral iron groups (p=0.048 and p<0.001, respectively). Neonatal head circumference, 1-minute Apgar, and 5-minute Apgar scores were similar in all three groups.

Conclusion: FCM is effective in pregnant women with IDA in late pregnancy and women undergoing this treatment deliver healthier newborns.
Pure Endoscopic Endonasal Treatment of Acromegaly; Classification, Remission Rates, Factors Affecting Remission, and Complications
Authors: DU DERYA , NACAR OSMAN
Published: October 2023

Aim
This study aims to evaluate the effectiveness of the pure endoscopic endonasal transsphenoidal (PEET) approach in treating acromegaly, focusing on remission criteria set by the 2002 and 2010 consensus guidelines. It also seeks to identify variables that affect remission and to analyze early postoperative IGF-1 levels 24 hours after surgery to determine their predictive value for remission.
Material and Methods
The study retrospectively reviewed the medical records of 129 acromegaly patients who underwent the PEET (Pure Endoscopic Endonasal Transsphenoidal) surgical approach between November 2010 and March 2016 at Ankara Numune Training and Research Hospital. Out of these, 124 patients with complete follow-up and laboratory data were included in the analysis. The study evaluated a range of variables including patients' symptoms, pre- and postoperative GH and IGF-1 levels, imaging results, and remission statuses based on the 2002 and 2010 consensus guidelines. Inclusion criteria for the study required patients to have specific preoperative and postoperative data and a minimum follow-up duration of at least 6 months.
Results
The study found statistically significant differences between the remission rates based on the 2002 and 2010 consensus criteria for acromegaly, with a 73.4% remission rate under the 2002 criteria and a 65.3% remission rate under the 2010 criteria (p=0.002). Multivariate logistic regression analysis indicated that the atypical nature of the adenoma (p=0.018) and surgical intervention due to recurrence (p=0.028) were significant negative factors affecting cure rates. The study also identified that advanced stages in Hardy Wilson (p=0.008) and Knosp (p<0.001) classifications had a statistically significant negative impact on achieving a cure. No statistically significant predictive value was found for early postoperative IGF-1 levels in relation to cure (p=0.612).
Conclusion:
PEET is currently the preferred treatment option for GH-secreting pituitary adenomas and has high remission rates.