bluuebunny/crossref_metadata_2025 huggingface dataset:
‘A priori’ external contextual factors and relationships with process indicators: a mixed methods study of the pre-implementation phase of ‘Communities in Charge of Alcohol’
Authors: Burns Elizabeth J. , Hargreaves Suzy C. , Ure Cathy , Hare Susan , Coffey Margaret , Hidajat Mira , Audrey Suzanne , de Vocht Frank , Ardern Kate , Cook Penny A.
Published: November 2022

Background

It is widely recognised that complex public health interventions roll out in distinct phases, within which external contextual factors influence implementation. Less is known about relationships with external contextual factors identified a priori in the pre-implementation phase. We investigated which external contextual factors, prior to the implementation of a community-centred approach to reducing alcohol harm called ‘Communities in Charge of Alcohol’ (CICA), were related to one of the process indicators: numbers of Alcohol Health Champions (AHCs) trained.

Methods

A mixed methods design was used in the pre-implementation phase of CICA. We studied ten geographic communities experiencing both high levels of deprivation and alcohol-related harm in the North West of England. Qualitative secondary data were extracted from pre-implementation meeting notes, recorded two to three months before roll-out. Items were coded into 12 content categories using content analysis. To create a baseline ‘infrastructure score’, the number of external contextual factors documented was counted per area to a maximum score of 12. Descriptive data were collected from training registers detailing training numbers in the first 12 months. The relationship between the baseline infrastructure score, external contextual factors, and the number of AHCs trained was assessed using non-parametric univariable statistics.

Results

There was a positive correlation between baseline infrastructure score and total numbers of AHCs trained (Rs = 0.77, p = 0.01). Four external contextual factors were associated with significantly higher numbers of lay people recruited and trained: having a health care provider to coordinate the intervention (p = 0.02); a pool of other volunteers to recruit from (p = 0.02); a contract in place with a commissioned service (p = 0.02), and; formal volunteer arrangements (p = 0.03).

Conclusions

Data suggest that there were four key components that significantly influenced establishing an Alcohol Health Champion programme in areas experiencing both high levels of deprivation and alcohol-related harm. There is added value of capturing external contextual factors a priori and then testing relationships with process indicators to inform the effective roll-out of complex interventions. Future research could explore a wider range of process indicators and outcomes, incorporating methods to rate individual factors to derive a mean score.

Trial registration

ISRCTN81942890, date of registration 12/09/2017.
Localization of the ilioischial line on axial computed tomography images for preoperative planning of total hip arthroplasty
Authors: Kato Michitaka , Warashina Hideki , Kataoka Akito , Ando Takanori , Mitamura Shingo
Published: November 2022

Background

If the bony region indicating the ilioischial line is established on the preoperative axial computed tomography (CT) image, the distance between the simulated cup and the ilioischial line can be measured on this image so that the surgeon can use these data to define a more accurate preoperative two-dimensional (2D) template of total hip arthroplasty (THA). This study aimed to verify the hypothesis that on the CT axial image, the cortical bone area, indicated by the superimposition of a line (line α) with a perspective projection angle to the ilioischial line on radiography and tangent to the medial acetabular wall, is the cortical bone that represents the ilioischial line on radiography.

Methods

Study 1: If the two measured distances (distance A’ and distance B) are sufficiently equal, then the hypothesis can be supported. Distance A’ was calculated by multiplying the distance A, between the ilioischial line and the medial margin of the metal cup after THA measured at the level of the hip joint center on the pelvic radiograph, by 0.91 to correct for radiographic magnification. Distance B was defined as the distance between the medial margin of the metal cup and line α on the axial CT image at the level of the hip joint center. These two distances were measured for all 51 hip joints included in the study.

Study 2: The difference between distance A and distance A# (distance A on the 2D template) was compared between the group containing 59 primary THAs in which distance B′ was measured (distance B in the simulation) and the control group containing 59 primary THAs.

Results

Study 1: The average distance for A’ was 4.5 ± 2 mm, and the average distance for B was 4.7 ± 2.1 mm. The difference between distances A and B was 0.2 ± 0.2 mm.

Study 2: The mean difference between distance A and distance A# for the measurement and control groups was 1.8 ± 1.3 mm and 3.7 ± 2.4 mm, respectively (P < 0.001).

Conclusions

The ilioischial line is located in the bony region where line α intersects the medial acetabular wall with a maximum overlap on axial CT images.
First-year medical students’ perceptions of a self-regulated learning-informed intervention: an exploratory study
Authors: Boyd Taylor , Besche Henrike , Goldhammer Richard , Alblooshi Afaf , Coleman Bradley I.
Published: November 2022

Background

Students with developed self-regulated learning (SRL) skills demonstrate an ability to set individualized educational goals, select optimal learning strategies for reaching these goals, and reflect on overall progress. The primary aims of this study were to investigate first-year medical students’ perceived utility of a self-regulated learning-informed intervention and to assess the impact of its implementation on students’ intended use of SRL throughout medical school.

Methods

A two-part educational intervention focused on SRL skill development was carried out at Harvard Medical School during the start of the 2021 academic year. For the first component of the intervention, 169 first-year medical students engaged in an interactive class session structured around SRL concept videos, a brief lecture, small group discussions and individual reflection. Students completed pre- and post-intervention surveys which inquired about learners’ current and anticipated application of SRL skills. During the second component of the intervention, 15 first-year medical students participated in a set of one-on-one academic SRL coaching sessions. All coaching participants completed follow-up semi-structured interviews.

Results

A statistically significant increase was observed between students’ use of skills in all domains of self-regulated learning prior to the intervention and their anticipated use of these skills following the intervention. Prior to the intervention, 60.1% (n = 92) of students reported utilizing evidence-based learning strategies, compared to 92.8% (n = 142) of students (p < 0.001) who anticipated applying this SRL skills at the completion of the classroom session. Six core themes emerged from qualitative analysis of the post-intervention survey including learning plan development, accountability and progress tracking, goals for growth, engagement through active learning, routine reflection, and adapting to the curriculum.

Conclusions

Both classroom-based learning sessions and one-on-one academic coaching programs are feasible approaches for encouraging the use of self-regulated learning techniques in the preclinical setting.
Senior surgeons as role models in the operating theatre: a thematic analysis through the lens of aristotelian ethics
Authors: Leung-Tack Mirana , Khanna Divya , Jones June , Elledge Ross O. C.
Published: November 2022

Background

Surgeons are commonly evaluated by surgical skills and outcomes rather than their character traits. We sought to examine role model behaviours of senior surgeons through the lens of Aristotelian (virtue) ethics.

Methods

Semi-structured focus group interviews were undertaken of anaesthetic trainees at a large university hospital NHS Foundation Trust and transcripts were subjected to thematic analysis to yield themes and subthemes. Participation of the trainees was entirely voluntary and focus groups were conducted using Zoom™.

Results

The overarching themes identified were ‘Teamwork makes the dream work’, ‘Captain of the ship’ and ‘Strong foundations’.

Conclusion

We hope to take lessons learnt in conjunction with our previous work to help refocus surgical training towards a process of character reformation, rather than simply imparting technical skills to trainees.
Involvement in the tumor-infiltrating CD8+ T cell expression by the initial disease of remnant gastric cancer
Authors: Kakiuchi Yoshihiko , Kikuchi Satoru , Kuroda Shinji , Kagawa Shunsuke , Fujiwara Toshiyoshi
Published: November 2022

Background

Remnant gastric cancer (RGC) has been increasing for various reasons such as a longer life span, medical progress, and others. It generally has a poor prognosis, and its mechanism of occurrence is unknown. The purpose of this study was to evaluate the clinicopathological features of and clarify the oncological features of RGC.

Methods

Between January 2002 and January 2017, 39 patients with RGC following distal gastrectomy underwent curative surgical resection at the Okayama University Hospital; their medical records and immunohistochemically stained extracted specimens were used for retrospective analysis.

Results

On univariate analysis, initial gastric disease, pathological lymph node metastasis, and pathological stage were the significant factors associated with poor overall survival (p=0.014, 0.0061, and 0.016, respectively). Multivariate analysis of these 3 factors showed that only initial gastric disease caused by malignant disease was an independent factor associated with a poor prognosis (p=0.014, hazard ratio: 4.2, 95% confidence interval: 1.3–13.0). In addition, tumor-infiltrating CD8+ T cells expression was higher in the benign disease group than in the malignant group (p=0.046).

Conclusions

Initial gastrectomy caused by malignant disease was an independent poor prognostic factor of RGC, and as one of the causes, lower level of tumor-infiltrating CD8+ T cells in RGC may involve in.
T3E: a tool for characterising the epigenetic profile of transposable elements using ChIP-seq data
Authors: Almeida da Paz Michelle , Taher Leila
Published: November 2022

Background

Despite the advent of Chromatin Immunoprecipitation Sequencing (ChIP-seq) having revolutionised our understanding of the mammalian genome’s regulatory landscape, many challenges remain. In particular, because of their repetitive nature, the sequencing reads derived from transposable elements (TEs) pose a real bioinformatics challenge, to the point that standard analysis pipelines typically ignore reads whose genomic origin cannot be unambiguously ascertained.

Results

We show that discarding ambiguously mapping reads may lead to a systematic underestimation of the number of reads associated with young TE families/subfamilies. We also provide evidence suggesting that the strategy of randomly permuting the location of the read mappings (or the TEs) that is often used to compute the background for enrichment calculations at TE families/subfamilies can result in both false positive and negative enrichments. To address these problems, we present the Transposable Element Enrichment Estimator (T3E), a tool that makes use of ChIP-seq data to characterise the epigenetic profile of associated TE families/subfamilies. T3E weights the number of read mappings assigned to the individual TE copies of a family/subfamily by the overall number of genomic loci to which the corresponding reads map, and this is done at the single nucleotide level. In addition, T3E computes ChIP-seq enrichment relative to a background estimated based on the distribution of the read mappings in the input control DNA.

We demonstrated the capabilities of T3E on 23 different ChIP-seq libraries. T3E identified enrichments that were consistent with previous studies. Furthermore, T3E detected context-specific enrichments that are likely to pinpoint unexplored TE families/subfamilies with individual TE copies that have been frequently exapted as cis-regulatory elements during the evolution of mammalian regulatory networks.

Conclusions

T3E is a novel open-source computational tool (available for use at: https://github.com/michelleapaz/T3E) that overcomes some of the pitfalls associated with the analysis of ChIP-seq data arising from the repetitive mammalian genome and provides a framework to shed light on the epigenetics of entire TE families/subfamilies.
Next-generation proteomics of serum extracellular vesicles combined with single-cell RNA sequencing identifies MACROH2A1 associated with refractory COVID-19
Authors: Kawasaki Takahiro , Takeda Yoshito , Edahiro Ryuya , Shirai Yuya , Nogami-Itoh Mari , Matsuki Takanori , Kida Hiroshi , Enomoto Takatoshi , Hara Reina , Noda Yoshimi , Adachi Yuichi , Niitsu Takayuki , Amiya Saori , Yamaguchi Yuta , Murakami Teruaki , Kato Yasuhiro , Morita Takayoshi , Yoshimura Hanako , Yamamoto Makoto , Nakatsubo Daisuke , Miyake Kotaro , Shiroyama Takayuki , Hirata Haruhiko , Adachi Jun , Okada Yukinori , Kumanogoh Atsushi
Published: November 2022

Background

The coronavirus disease 2019 (COVID-19) pandemic is widespread; however, accurate predictors of refractory cases have not yet been established. Circulating extracellular vesicles, involved in many pathological processes, are ideal resources for biomarker exploration.

Methods

To identify potential serum biomarkers and examine the proteins associated with the pathogenesis of refractory COVID-19, we conducted high-coverage proteomics on serum extracellular vesicles collected from 12 patients with COVID-19 at different disease severity levels and 4 healthy controls. Furthermore, single-cell RNA sequencing of peripheral blood mononuclear cells collected from 10 patients with COVID-19 and 5 healthy controls was performed.

Results

Among the 3046 extracellular vesicle proteins that were identified, expression of MACROH2A1 was significantly elevated in refractory cases compared to non-refractory cases; moreover, its expression was increased according to disease severity. In single-cell RNA sequencing of peripheral blood mononuclear cells, the expression of MACROH2A1 was localized to monocytes and elevated in critical cases. Consistently, single-nucleus RNA sequencing of lung tissues revealed that MACROH2A1 was highly expressed in monocytes and macrophages and was significantly elevated in fatal COVID-19. Moreover, molecular network analysis showed that pathways such as “estrogen signaling pathway,” “p160 steroid receptor coactivator (SRC) signaling pathway,” and “transcriptional regulation by STAT” were enriched in the transcriptome of monocytes in the peripheral blood mononuclear cells and lungs, and they were also commonly enriched in extracellular vesicle proteomics.

Conclusions

Our findings highlight that MACROH2A1 in extracellular vesicles is a potential biomarker of refractory COVID-19 and may reflect the pathogenesis of COVID-19 in monocytes.
Dependence of electrical conduction on pore structure in reservoir rocks from the Beibuwan and Pearl River Mouth Basins: A theoretical and experimental study
Authors: Chen Xiaojun , Thanh Luong Duy , Luo Chengfei , Tahmasebi Pejman , Cai Jianchao
Published: November 2022

The electrical conduction of reservoir rocks is crucial for estimating hydrocarbon and water saturation. The dependence of the electrical formation factor as a key parameter of electrical conduction on pore structure is analyzed through theoretical development, petrophysical experiments, error analysis, core-scale displacement experiments, and pore-scale numerical simulations. Through the tortuous fractal capillary bundle pore model, the electric formation factor is theoretically a function of three pore structure parameters: porosity, tortuosity fractal dimension, and pore fractal dimension. Through rock-electrical experiments from 46 reservoir rocks from the Beibuwan and Pearl River Mouth Basins, Thanh’s model can give a satisfactory performance with a suitable value for the ratio of minimum to maximum pore radius. Porosity-based formation factor models, including classical Archie’s law, have an unacceptable error at high formation factor. Our formation factor model provides better predictions with an error factor of ±10. The Archie’s cementation exponent can be expressed as the average tortuous degree of electrical conduction paths. The dependences of hydraulic and electrical conductions on pore structure are distinctly different. Hydraulic conductance has obvious pore-size dependence, the dominant flow channel, and threshold pressure, which are affected by displacement order. However, the case of electrical conduction is the opposite, in which electrical conduction has no dominant channel, and does not reflect the pore-size information under the same porosity.
Stepsize sharing in time-lapse full-waveform inversion
Authors: Fu Xin , Innanen Kristopher A.
Published: November 2022

Full-waveform inversion (FWI) methods can produce high-resolution images of the physical properties of the subsurface. FWI has become a powerful tool for time-lapse or 4D seismic inversion, with applications in the monitoring of reservoir changes with injection and production, and potentially long-term storage of carbon. Current time-lapse FWI strategies include the parallel strategy (PRS), the sequential strategy, the double-difference strategy (DDS), the common-model strategy (CMS), and the central-difference strategy (CDS). PRS time-lapse inversion is affected by convergence differences between the baseline and monitoring inversions, as well as nonrepeatable noise and nonrepeatable acquisition geometries between surveys. The other strategies are largely efforts to fix the sensitivities of PRS, but robust solutions are still sought. We hypothesize that several problems in time-lapse FWI arise from the independence of step lengths during updating. This is supported by synthetic data tests, which indicate that stepsize sharing reduces artifacts caused by the variability in PRS convergence. Two strategies, which we refer to as stepsize-sharing PRS (SSPRS) and stepsize-sharing CMS, are then designed to address these remaining issues. In this paper, we have tested our methods in five scenarios, including noise-free data, nonrepeated noises, nonrepeatable source positions, biased starting models, and a combination of the latter three. The comparisons between the SSPRS and other strategies indicate that the SSPRS can adapt to all tested scenarios well. Especially, except for the DDS which is extremely sensitive to the nonrepeatable source positions, only the SSPRS can provide meaningful results in the latter two scenarios when compared with others. Furthermore, given that SSPRS through its sharing incurs half of the time cost of seeking stepsizes compared with the PRS and DDS, the total computational cost of SSPRS is less than half of that of the CMS and CDS.
Fast-forward modeling of borehole nuclear magnetic resonance measurements acquired in deviated wells and spatially heterogeneous formations
Authors: Albusairi Mohammad , Torres-Verdín Carlos
Published: November 2022

High-angle and horizontal (HAHz) wells are routinely drilled to enhance reservoir exposure and increase fluid productivity. The interpretation of nuclear magnetic resonance (NMR) measurements entails major technical challenges in horizontal layers penetrated by HAHz wells or through dipping formation layers penetrated by a vertical well. Three-dimensional geometric effects, coupled with spatially and petrophysically heterogeneous rocks, may bias petrophysical estimates obtained from borehole NMR measurements using methods designed for vertical wells and horizontal layers. Reliable interpretation requires an accurate and rapid forward-modeling method that integrates NMR physics and tool/instrument specifications, borehole, and 3D formation geometric properties. The latter is possible with the recent development of a forward-modeling algorithm that accurately and efficiently simulates NMR measurements based on 3D spatial sensitivity functions (SSFs). We implement and quantify this forward-modeling approximation across dipping formations penetrated by deviated wells in the presence of mud-filtrate invasion. We validate and verify the fast approximation against a 3D multiphysics model using challenging synthetic cases, in highly apparent dip wells with the varying radial front of the mud-filtrate invasion. Our work compares the effect of radial length of investigation from the three distinct NMR acquisition shells to better understand borehole NMR measurements acquired in 3D complex geometries. On average, the fast approximation via SSFs reproduces NMR measurements in 3 s of central processing unit time with maximum root-mean-square errors below 1% and can therefore be used for real-time calculations and interpretations. Modeling results indicate that thinly bedded formations and their petrophysical properties can be resolved with relatively low measurement resolution in HAHz wells and dipping formations.
Finding the Center:Mrs Dalloway's Bureaucrats and State Centralization
Authors: Hentea Marius
Published: November 2022

Although the rise of the bureaucratic state was one of the most startling transformations of early twentieth-century British society, novelists raised on a diet of laissez-faire liberalism tended to shy away from direct representations of bureaucracy (with some prominent exceptions, such as the Circumlocution Office in Charles Dickens's Little Dorrit or Anthony Trollope's Three Clerks). Although squarely set within the “governing-class spirit” of Westminster and populated with a bevy of civil servants, Virginia Woolf's Mrs Dalloway tends to be read as maintaining a strict public-private division with a marked preference for the richness and beauty of private life. This article argues that Woolf, no stranger to the civil service through her family and personal networks, had a more strained and ambivalent response to bureaucracy as an idea and government form. A close reading of the structural importance of Hugh Whitbread's character, a minor figure who is often read as an empty, flat Dickensian caricature of the gentleman, shows a more ambivalent response to how bureaucracy and its forms impacted the wider concerns raised about governmentality in Woolf's novel.
The End of the City and the Coming of the Urban: Georges Perec's An Attempt at Exhausting a Place in Paris
Authors: Soule Jacob
Published: November 2022

Georges Perec's short experimental novella An Attempt at Exhausting a Place in Paris documents, with inert fascination, everything that passes through the busy Parisian square of Place Saint-Sulpice over the course of several days, from pedestrians to the continuous stream of buses and taxis. Why, this article asks, does Perec present this magisterial and oft-storied city in centrifugal terms as a place through which things only pass on their way to somewhere else? Once characterized as a rich tapestry of architecture and possible encounters, Paris in 1975 is, from the perspective of this novelist, transformed beyond recognition by the infrastructure of circulation. No longer the imagined center of a productive economy that draws people and objects into its orbit in order to assign them places as characters in the vast amphitheater of class relations—as in the classic city novels of Balzac or Eugène Sue—Perec's experiment shows the social space of the city in the process of becoming only one site among others in the postwar project of urbanization. On this basis, Perec's novella marks the 1970s as an important transition point in the history of the city novel: the old city, once a site of social possibility and conflict, seems to be in its final stage of exhaustion by the centrifugal forces of urbanization. As the process of urbanization becomes legible through its disfigurations of the traditional city novel, the novel forecasts what happens when the spatial development of global capitalism eclipses national culture and its arrangement of people and things.
Loss of WNT4 in the gubernaculum causes unilateral cryptorchidism and fertility defects
Authors: Seth Abhishek , Bournat Juan C. , Medina-Martinez Olga , Rivera Armando , Moore Joshua , Flores Hunter , Rosenfeld Jill A. , Hu Liya , Jorgez Carolina J.
Published: November 2022

Undescended testis (UDT) affects 6% of male births. Despite surgical correction, some men with unilateral UDT may experience infertility with the contralateral descended testis (CDT) showing no A-dark spermatogonia. To improve our understanding of the etiology of infertility in UDT, we generated a novel murine model of left unilateral UDT. Gubernaculum-specific Wnt4 knockout (KO) mice (Wnt4-cKO) were generated using retinoic acid receptor β2-cre mice and were found to have a smaller left-unilateral UDT. Wnt4-cKO mice with abdominal UDT had an increase in serum follicle-stimulating hormone and luteinizing hormone and an absence of germ cells in the undescended testicle. Wnt4-cKO mice with inguinal UDT had normal hormonal profiles, and 50% of these mice had no sperm in the left epididymis. Wnt4-cKO mice had fertility defects and produced 52% fewer litters and 78% fewer pups than control mice. Wnt4-cKO testes demonstrated increased expression of estrogen receptor α and SOX9, upregulation of female gonadal genes, and a decrease in male gonadal genes in both CDT and UDT. Several WNT4 variants were identified in boys with UDT. The presence of UDT and fertility defects in Wnt4-cKO mice highlights the crucial role of WNT4 in testicular development.
Mitochondria-associated niches in health and disease
Authors: Milani Mateus , Pihán Philippe , Hetz Claudio
Published: November 2022

The appreciation of the importance of interorganelle contacts has steadily increased over the past decades. Advances in imaging, molecular biology and bioinformatic techniques allowed the discovery of new mechanisms involved in the interaction and communication between organelles, providing novel insights into the inner works of a cell. In this Review, with the mitochondria under the spotlight, we discuss the most recent findings on the mechanisms mediating the communication between organelles, focusing on Ca2+ signaling, lipid exchange, cell death and stress responses. Notably, we introduce a new integrative perspective to signaling networks that is regulated by interorganelle interactions – the mitochondria-associated niches – focusing on the link between the molecular determinants of contact sites and their functional outputs, rather than simply physical and structural communication. In addition, we highlight the neuropathological and metabolic implications of alterations in mitochondria-associated niches and outline how this concept might improve our understanding of multi-organelle interactions.
Liraglutide as an innovative and multifunctional drug for patients with obesity – the current state of knowledge and future prospects
Authors: Grodkiewicz Maria , Kozieł Paweł , Artykiewicz Klaudia , Gorczyca Kamila , Czarkowski Marcin , Słupczyńska Aleksandra , Urbaś Weronika , Podgórska Klaudia , Puła Aleksandra , Krzysiek Urszula
Published: November 2022

Obesity is considered a disease of civilization representing a global health and social problem. Currently, 21% of adult Poles suffer from obesity, so every fifth patient contacted by a doctor is obese. Obesity is a chronic disease, associated with excessive accumulation of adipose tissue, which causes a deterioration in the health and quality of life of an obese patient. It also consequently leads to an increased risk of developing many diseases - including cardiovascular, metabolic and neoplastic diseases. Excessive body weight ranks sixth in importance as a risk factor responsible for the number of deaths worldwide. The mainstay of obesity treatment is lifestyle modification. It includes changing eating habits and increasing physical activity. However, due to the high prevalence of obesity in developed countries, its serious consequences and the unsatisfactory effect of weight loss in some patients with an appropriate diet, pharmacological methods of obesity treatment were searched for. Currently, there are three drugs approved for the treatment of obesity in Poland: orlistat, a combined preparation of naltrexone + bupropion and liraglutide – agonist of a glucagon-like peptide-1 receptor. The effectiveness of one of them - liraglutide - is particularly significant, and the effect of this drug in reducing cardiovascular risk is also promising, which is extremely important in obese patients. For this reason, in the latest recommendations of the Polish Obesity Treatment Association, liraglutide is indicated as the drug of first choice for obese or overweight patients with a BMI ≥27 kg / m2, in whom coexisting: pre-diabetes, type 2 diabetes, arterial hypertension, polycystic ovary syndrome, nonalcoholic fatty liver disease, metabolic syndrome, atherosclerosis or sleep apnea syndrome. Due to the presence of GLP-1 receptors in many organs, the use of liraglutide in the future would probably extend to more diseases than obesity and type 2 diabetes.
Multiple Myeloma Presenting as Acute Kidney Failure Secondary to Lambda Light Chain Deposition
Authors: Emond-Boisjoly Marie-Eve , Lemieux-Blanchard Emilie , Maietta Antonia , Forté Stéphanie
Published: November 2022

Renal monoclonal immunoglobulin deposition disease (MIDD) is a rare disease defined by deposition of monoclonal light chains and/or heavy chains on basement membranes and vascular walls of the kidney. We describe a case of a 71-year-old woman with kidney failure secondary to monoclonal immunoglobulin deposition disease lambda in association with plasma cell dyscrasia. Her initial serum protein electrophoresis did not demonstrate a monoclonal protein, and classic cast nephropathy was absent on renal biopsy. However, lambda light chain deposits and associated changes confirmed MIDD. She achieved a very good partial response (VGRP) after 8 cycles of CyBorD (cyclophosphamide, bortezomib, dexamethasone) and her kidney function improved. This case highlights the importance of an early diagnostic with renal biopsy to prevent end-stage renal disease. A review of the existing literature and a discussion on the management of the disease is presented.
Bilateral Full-Thickness Macular Hole Formation After Single Dose of Intravitreal Conbercept Injection
Authors: Wu Min , Min Jie , Sheng Zhichao
Published: November 2022

Aim: To report a case of bilateral full-thickness macular hole formation after a single dose of conbercept injection.

Method: A 46-year-old high myopic female developed full-thickness macular hole in both eyes at 7 and 19 days after intravitreal injection of conbercept. The myopic foveoschisis was misdiagnosed as macular edema. The macular holes in both eyes were repaired surgically.

Results: The macular holes in both eyes were repaired successfully by surgery.

Conclusion: The full-thickness macular hole formation could occur after anti-VEGF treatment. The possible reasons for this case might be traction caused by anti-VEGF agent or progression of myopic foveoschisis and PVD.
TRADUCCIÓN, ÉTICA E IDEOLOGÍA EN LA ÉPOCA DE LA GLOBALIZACIÓN
Authors: Tymoczko Maria
Published: November 2022

Maria Tymoczko, University of Massachusetts
OS SERTÕES (RE)ESCRITO POR ENRIQUE PÉREZ MARILUZ: EL RESUMEN COMO OBRA NUEVA
Authors: Gomes Mitizi
Published: November 2022

Mitizi Gomes, Universidade Federal do Rio Grande do Sul
RECEPCIÓN DE LA LITERATURA RUSA SOVIÉTICA EN ESPAÑA: EL MAESTRO Y MARGARITA Y OTRAS OBRAS DE MIJAÍL BULGÁKOV.
Authors: MYCHO-MEGRIN Irina
Published: November 2022

Irina Mychko-Megrin, Universitat de Barcelona
TRANSLATING THE AFRICAN AMERICAN EXPERIENCE ON THE STAGE: THE CASE OF ADRIENNE KENNEDY
Authors: Requena-Pelegrí Teresa
Published: November 2022

Teresa Requena Pelegrí, Universitat de Barcelona
Algunos apuntes sobre la traducción cultural
Authors: Selva Pereira Tatiana Antonia
Published: November 2022

In the complex existing relations between translation and culture, this article intends not only to analyze some of the issues involved in the so-called “cultural translation”, but to point out the strategic role of the translator as a cultural mediator in the whole process.
Crítica literaria y traducción cultural: una problematización del “boom” de la narrativa latinoamericana
Authors: Mallmann Vallerius Denise
Published: November 2022

Bearing in mind the important role of literary mediators –translators, critics, editors, etc,- in building up the world literary space, this study intends to do research on the image of the Spanish America that was discursively built by those mediators, departing from the so-called "boom" of the Spanish-speaking America, and from the viewpoint of the empowered literary systems.
La intertextualidad y el problema de la autoría literaria en la obra de J.L. Borges
Authors: MYCHO-MEGRIN Irina
Published: November 2022

This paper deals with the intertextuality in the works of Jorge Luís Borges, who is well known as a great experimentalist in the field of literature and as a “blind librarian” devoted to books. His “literary exercises”, as he called them, are woven of quotations of other texts and it’s often difficult to distinguish between his fiction-stories and critical essays. Borges’ concept of literature is based on continuity, where the problem of authorship hardly exists. A brief analysis of some of his short stories shows the way he understands the mechanism of quotation and it’s relation to other kinds of distortion and multiplication of reality, expressed through the images of the “mirror” and the “double”.
Jiménez Bellver, Jorge: Reseña del libro Translator’s Agency
Authors: Jiménez Bellver Jorge
Published: November 2022

Jiménez Bellver, Jorge: Review of Tuija Kinnunen & Kaisa Koskinen (eds.). (2010). Translators’ Agency. Tampere: Tampere University Press, 187 pp.
MYCHO-MEGRIN, Irina (UB): EL LENGUAJE “INTRADUCIBLE” DE ZÓSCHENKO: EN EL REINO DE LA INCONGRUENCIA
Authors: MYCHO-MEGRIN Irina
Published: November 2022

Existen varios factores que pueden influir en la recepción de un determinado autor o una determinada obra en el extranjero. Uno de estos factores es la resistencia del texto a la traducción, es decir, su grado de conexión con la cultura de origen, con una cosmovisión, una realidad concreta. La “intraducibilidad” del texto a menudo radica en el estilo del autor, en su manera particular de narrar y el lenguaje empleado. Mijaíl Zóschenko puede ser considerado un autor “difícil” en este sentido, un verdadero quebradero de cabeza para los traductores. De esta forma, el propósito del presente artículo es revelar los motivos de esta dificultad y estudiar los problemas traductológicos que implican los relatos satíricos de Zóschenko desde el punto de vista cultural y lingüístico.
LUNA ALONSO, Ana (U. Vigo): Estudio de las antologías poéticas gallegas traducidas al castellano. Análisis cuantitativo y cualitativo.
Authors: LUNA ALONSO Ana
Published: November 2022

El importante volumen de antologías poéticas traducidas hacia y desde la lengua galle-ga surgidas en el ámbito ibérico durante los primeros años de la democracia nos ha llevado a reflexionar sobre el rendimiento de largo recorrido que han tenido este tipo de textos para el sistema literario. Hemos delimitado el objetivo de este artículo al fenómeno antológico de la exportación de la poesía gallega hacia el campo cultural del castellano en la Península Ibérica y nos hemos centrado en los últimos cuarenta años. Para ello, comenzamos por enunciar algunas consideraciones metodológicas que pretenden delimitar el objeto de estudio, al tiempo que tratamos de reconocer algunas áreas de problematicidad que afectan a los términos pertinentes en este análisis. A continuación, examinamos la fun-ción desempeñada por los agentes y empresas editoriales, a fin de permitir deducir las principales estrategias implicadas en los procesos de recepción poética. Nos interesa saber qué textos se han exportado y cómo se ha presentado la cultura gallega en el exterior a través de la antología y para ello analizamos a modo de ejemplo algunos de los paratextos de publicaciones de los años setenta (Genette 1982) en los que se expresan las motivaciones del formato elegido, los objetivos e intencio-nes frente a modelos más actuales. Dicho análisis servirá para destacar el carácter particular de las antologías líricas, identificar tendencias en la publicación de este tipo de obras en el ámbito hispano y ofrecer un balance provisional de las prácticas de exportación de la poesía gallega.
¿CUÁN “NATURAL” ES “LO NATURAL”? ECOCRÍTICA Y TRADUCCIÓN
Authors: Camps Assumpta
Published: November 2022

Varios críticos han señalado recientemente la relevancia de la Ecocrítica para la teoría y la práctica de la Traducción, y han puesto de manifiesto algunos de los muchos enfoques desde los cuales desarrollar una conciencia ecológica de la Traducción, que incluya –sin limitarse a– la conciencia medioambiental.      Más allá del reconocimiento de la globalización como una de las múltiples fuerzas que impactan y, a su vez, se ven impactadas por la labor de los traductores/ intérpretes, y más allá también de la conciencia de la traducción como un fenómeno global y una práctica que puede trabajar en pro o en contra de los derechos humanos (incluidos los derechos de los grupos socialmente más desfavorecidos), nuestro punto de partida en este artículo es el convencimiento de que los espacios sociales en la era global son, en realidad, zonas traslacionales donde tienen lugar encuentros lingüísticos tanto como culturales. El estudio de la economía geopolítica propia de los intercambios entre culturas, identidades, comunidades e individuos a escala global muestra que dichos intercambios están lejos de ser simétricos y bidireccionales, a pesar de que tal desequilibrio no siempre es percibido, especialmente en el/los discurso(s) oficial/es sobre la diversidad. En ese sentido, llevar a cabo el análisis de dichos espacios y procesos asimétricos (que actualmente son cada vez más etnodiversos, multilingües y multiculturales) desde el punto de vista de la Traducción y con una perspectiva ecocrítica puede ser significativamente relevante para trabajar en pro de la cohesión social en sociedades multiculturales, ya sea en lo concerniente a la negociación de la diferencia o al desarrollo de la equidad, incluida la equidad de género.      Partiendo de una breve panorámica sobre la evolución de la Ecocrítica, en este artículo nos proponemos analizar las aportaciones del pensamiento ecológico cultural a la Traducción en las últimas décadas, así como las oportunidades y los retos que esto ha comportado. En este sentido, reflexionaremos sobre conceptos clave como “naturaleza” y “lo natural” aplicados a este campo, y tomaremos en consideración la necesidad de una nueva ética de la traducción con perspectiva ecocrítica.
Image Gathering and Digital Restoration: End-To-End Optimization for Visual Quality
Authors: Huck Friedrich O. , John Sarah , McCormick Judith A. , Narayanswamy Ramkumar
Published: November 2022

Image gathering and digital restoration are commonly treated as separate tasks. However, it is possible to gain significant improvements in fidelity, resolution, sharpness, and clarity when these two tasks are optimized together. In this paper, we demonstrate the improvements that can be gained when (1) the design of the image-gathering system is optimized for high information density rather than for conventional image reconstruction, and (2) the digital restoration of the image accounts for the aliasing as well as the blurring and noise in image gathering and practically eliminates the degradations that occur due to the blurring and raster effects in image reconstruction.
Effects of character size and chromatic contrast on reading performance
Authors: Knoblauch Kenneth , Arditi Aries
Published: November 2022

Recent work on the psychophysics of reading has concentrated primarily on achromatic (or luminance) contrast factors (Legge et al, 1985, 1986, 1987). In general, reading is fastest with text of high contrast defined by luminance contours. In the real world, however, chromatic as well as luminance edges abound. While several studies have examined the interaction of chromatic and luminance contrasts on stimuli near threshold (e.g., Mullen, 1987; Knoblauch et al, 1984; Jameson, 1985; Switkes et al, 1988), only a few have investigated suprathreshold levels. Legge et al, (1986) demonstrated that for observers with normal vision, the luminance contrast and not the color of text on a dark background determines reading rate. This finding is consistent with threshold studies that show that the color of a grating does not affect luminance contrast sensitivity either (Nelson and Halberg, 1979), provided that one avoids frequencies near the diffraction limit (Pokorny et al, 1968; Van Nes and Bouman, 1967).
Numerical approach to quantify depth-dependent blood flow changes in real-time using the diffusion equation with continuous-wave and time-domain diffuse correlation spectroscopy
Authors: Helton Michael , Rajasekhar Suraj , Zerafa Samantha , Vishwanath Karthik , Mycek Mary-Ann
Published: November 2022

Diffuse correlation spectroscopy (DCS) is a non-invasive optical technique that can measure brain perfusion by quantifying temporal intensity fluctuations of multiply scattered light. A primary limitation for accurate quantitation of cerebral blood flow (CBF) is the fact that experimental measurements contain information about both extracerebral scalp blood flow (SBF) as well as CBF. Separating CBF from SBF is typically achieved using multiple source-detector channels when using continuous-wave (CW) light sources, or more recently with use of time-domain (TD) techniques. Analysis methods that account for these partial volume effects are often employed to increase CBF contrast. However, a robust, real-time analysis procedure that can separate and quantify SBF and CBF with both traditional CW and TD-DCS measurements is still needed. Here, we validate a data analysis procedure based on the diffusion equation in layered media capable of quantifying both extra- and cerebral blood flow in the CW and TD. We find that the model can quantify SBF and CBF coefficients with less than 5% error compared to Monte Carlo simulations using a 3-layered brain model in both the CW and TD. The model can accurately fit data at a rate of <10 ms for CW data and <250 ms for TD data when using a least-squares optimizer.
Random laser in ordered colloidal suspensions
Authors: Jiménez-Villar Ernesto , Gomes Anderson A. V. , Wetter Niklaus U. , Dipold Jessica , Mestre Valdeci , Dominguez Christian T.
Published: November 2022

Random lasing is achieved in an ordered photonic colloidal (TiO2@Silica) suspension. Stronger correlation in the scatterers’ (TiO2@Silica) position, induced by stronger and longer-range Coulomb interaction improves light localization and random laser performance.
Digital Lensless holographic microscopy based on an optical pick-up unit
Authors: Tobón-Maya Heberley , Gómez-Ramírez Alejandra , Garcia-Sucerquia Jorge
Published: November 2022

Digital lensless holographic microscopy (DLHM) supported on an optical pickup unit (OPU) is presented. The whole OPU is utilized to replace the costly and fragile pinhole-based illumination in DLHM to image micrometer-sized specimens.
Laser photonic techniques applied to soil analysis for achieving low carbon agriculture
Authors: Bento Lucas R. , Oliveira Patrícia P. A. , Pezzopane José R. M. , de C. Bernardi Alberto C. , Magalhães Aida , Milori Débora M. B. P. , Martin-Neto Ladislau
Published: November 2022

Agriculture can stock carbon on soil increasing the organic matter content, and mitigating greenhouse gas emissions. LIBS and LIFS were used to evaluate different pasture systems, which showed that well-managed pastures can increase soil carbon stock.
Evaluation of Organic Matter Quality in cotton crop soil employing the Laser Induced Fluorescence Spectroscopy
Authors: Tadini Amanda M. , Gonçalves Evelyn C. , Souza Edicarlos D. , Milori Débora M.B.P. , Martin-Neto Ladislau
Published: November 2022

Soil organic matter (SOM) quality is fundamental for sustainable management practices. LIFS and Elemental Analysis showed increase of more stable SOM in systems with cotton rotation with other crops and pasture.
Experimental results of a quadrangular OLED prism topographer prototype with Dynamic Point Shifting
Authors: Valderrama-Juárez Carlos Enrique , Díaz-Uribe Rufino
Published: November 2022

Experimental results of the evaluation of three convex surfaces using the Null Screen method with DyPoS. Error reduction achieved to less of 1% on the radius of curvature and 15 m in RMS were obtained.
U-shaped POF sensor coated with Cu2O applied to H2S sensing
Authors: Lopez Juan D. , Cuenca Juan P. , Dante Alex , Bellini Renato T. , Silva Paulo H. , Allil Regina C. , Werneck Marcelo M.
Published: November 2022

This work presents two U-shaped Plastic Optical Fiber (POF) coated with Cu2O applied in Hydrogen sulfide (H2S) sensing. The POF sensors presented a rise time of around 10 min when tested with 200 ppm H2S.
Synthesis and characterization of NaY(MoO4)2 :Yb3+/Er3+-particles and cellulose based film- and its thermometry application
Authors: Do Marco Izabela Z. , da Silva Douglas L. , Caiut José Maurício A.
Published: November 2022

molybdates Er3+/Yb3+ ions co-doped were obtained by hydrothermal synthesis, and self-supported luminescent films based on bacterial cellulose were prepared with these particles. Up-conversion process was observed and the materials were intended for studies at different temperatures.
Simulating a hybrid 2D optomechanical crystal in anisotropic silicon
Authors: Kersul Cauê M. , Benevides Rodrigo , Moraes Flávio , Aguiar Gabriel , Groblacher Simon , Alegre Thiago P. M.
Published: November 2022

Here we study the effects of mechanical anisotropy in a 2D optomechanical crystal geometry. Our results show that the device orientation deeply affects its mechanical band structure, leading to the hybridization of different mechanical modes and degrading its optomechanical performance
Multiphoton interference of distinguishable photons based on photonic inner mode structure.
Authors: Alarcón J. , Villalobos Miguel , Quintero Andres Camilo , Valencia Alejandra
Published: November 2022

Two photon interference in transverse momentum variables is presented via spatially resolved correlation measurements. Interest is devoted to study theoretically and experimentally the interference when the input photons are distinguishable in their spatial variables.
Study of optical properties of zinc-tellurite glasses doped with Yb3+, Tm3+ and Er3+: Analysis of the influence of rare-earth ions doping on host matrix modification.
Authors: Chacaliaza-Ricaldi J. , Clabel H. J.L. , Lozano C. G. , Rivera V.A.G. , Marega E.
Published: November 2022

By means of UV-VIS absorption measurements to zinc-tellurite glasses doped with Yb, Tm and Er, we obtained the band gaps, Urbach energies, the polarizability values and the Judd-Ofelt parameters, which indicated an increase in the structural disorder in the host matrix.