bluuebunny/crossref_metadata_2025 huggingface dataset:
Musculoskeletal Multimorbidity Burden and Trajectory in Relation to Later‐Life Holistic Well‐Being Among Middle‐Aged and Elderly Individuals: A Prospective Study
Authors: Zhu Yuanpeng , Zhang Haoran , Li Qing , Zhang Terry Jianguo , Wu Nan
Published: November 2024

Objectives

Understanding the patterns and implications of coexisting musculoskeletal conditions is crucial for developing effective management strategies and improving care for older adults. This study aimed to examine the associations between musculoskeletal multimorbidity burden and trajectory and holistic well‐being among middle‐aged and older adults.

Methods

This prospective study employed data from nine consecutive waves of the English Longitudinal Study of Aging (ELSA), spanning 2002–2018. We used latent class trajectory models (LCTM) to identify groups based on changes in musculoskeletal multimorbidity status. Subsequently, we employed linear mixed models to investigate the associations between musculoskeletal disease burden, trajectory groups, and seven dimensions of holistic well‐being: Activities of Daily Living (ADLs), Instrumental Activities of Daily Living (IADLs), depression, memory, loneliness, social interactions, and life satisfaction.

Results

In total, 5272 participants (mean age: 71.9 years; SD: 8.9) were included in the final analysis. Four distinct trajectories were identified: a low‐burden group (48.37%), an emerging group (14.76%), a moderate‐burden group (26.00%), and a persistent burden group (10.87%). After adjustment, the findings demonstrate that the musculoskeletal disorder burden significantly impacts ADLs, depression, memory, social interactions, and life satisfaction in middle‐aged and older adults, with minor effects on IADLs and loneliness. Moreover, with the escalation of the burden, its impact significantly intensifies (p for trend is < 0.001). Compared with the low‐burden group, participants in both the moderate and persistent burden groups exhibited significantly lower capabilities in ADLs, poorer memory, increased social interactions, and lower life satisfaction. The emerging group displayed a similar trend, though without statistically significant results.

Conclusions

Our study suggests that the extent and persistence of musculoskeletal disease burden can significantly affect holistic well‐being among middle‐aged and older individuals.
Leaf Photosynthetic and Photoprotective Acclimation in the Ultraviolet‐A1 and Blue Light Regions Follow a Continuous, Shallow Gradient
Authors: Sun Xuguang , Kaiser Elias , Marcelis Leo F. M. , Li Tao
Published: November 2024

Although blue light is known to produce leaves with high photosynthetic capacity, the role of the blue‐adjacent UV‐A1 (350–400 nm) in driving leaf photosynthetic acclimation is less studied. Tomato plants were grown under hybrid red and blue (RB; 95/5 μmol m−2 s−1), as well as four treatments in which RB was supplemented with 50 μmol m−2 s−1 peaking at 365, 385, 410 and 450 nm, respectively. Acclimation to 365–450 nm led to a shallow gradient increase in trait values (i.e., photosynthetic capacity, pigmentation and dry mass content) as the peak wavelength increased. Furthermore, both UV‐A1 and blue light grown leaves showed efficient photoprotection under high light intensity. When treated plants were transferred to fluctuating light for 5 days, leaves from all treatments showed increases in photosynthetic capacity, which were strongest in RB, followed by additional UV‐A1 treatments; RB grown leaves showed reductions in maximum quantum yield of photosystem II, while UV‐A1 grown leaves showed increases. We conclude that both UV‐A1 and blue light effectively trigger photosynthetic and photoprotective acclimation, the extent of acclimation becoming stronger the longer the peak wavelength is. Acclimatory responses to UV‐A1 and blue light are thus not distinct from one another, but follow a continuous gradient.
Pediatric Cutaneous T‐Cell Neoplasms: Clinical and Pathological Features, Updated Classifications, and Critical Differential Diagnoses
Authors: Cheng Jinjun , Wistinghausen Birte , Kirkorian A. Yasmine
Published: November 2024

Cutaneous T‐cell lymphoid neoplasms in childhood are exceedingly rare, presenting with a wide spectrum of clinical presentation and outcomes. Due to numerous clinical and pathological mimics, an integrated evaluation of clinical, histopathological, immunohistochemical, and molecular findings is critical for a diagnosis. Here, we review the clinical and pathological features, updated classifications, and critical differential diagnoses of cutaneous T‐cell lymphoid neoplasms in children.
Pediatric Keloids: A Retrospective, Single‐Institution Cohort Analysis in Korea
Authors: Kim Jin Seop , Lee Ga‐Young , Chae Seoung Wan , Kim Won‐Serk , Choi Young‐Jun
Published: November 2024

Background/Objectives

There are scant established data on the cause, distribution, treatment options, and recurrence rate of pediatric keloids in Asian populations. We characterized clinical features by comprehensively categorizing pediatric keloid patients into prepubertal and postpubertal groups at a single tertiary center.

Methods

We searched the database of Kangbuk Samsung Hospital for pediatric patients (< 18 years) with clinically proven keloids who underwent outpatient‐based treatment from 2007 to 2021. Clinical features, including demographics, distribution, underlying cause, treatment modality, and recurrence, were analyzed.

Results

Of the 93 patients (total 110 keloids), 42 females (45.2%) and 51 males (54.8%), with a mean age of 14.5 ± 4.1 years (range, 1–18 years), were retrospectively analyzed. The mean length of follow‐up was 22.0 ± 14.2 months (range, 6–63). Of the 100 keloids with assessable causes, piercing (22%) and acne (19%) were the most common. In the prepubertal group, the lower and upper limbs (n = 7, 28%; n = 6, 24%) were the two most common locations, suggesting that post‐traumatic keloids are common during this developmental period. In the postpubertal group, the ear (n = 25, 29.4%) was the most common site, which corresponds to the frequency of cosmetic piercing at this age. No differences were found between the effects of treatment methods on relapse rate.

Conclusions

Understanding the clinical features of pediatric keloids is important in the therapeutic considerations for pediatric keloids. Future studies should analyze a larger number of children with keloids over longer observation periods.
Furcuncular Myiasis of the Scalp Caused by Chrysomya bezziana
Authors: Gaurav Vishal , Tyagi Mehul , Das Shukla , Pandhi Deepika
Published: November 2024

We report a rare case of furuncular myiasis in a 7‐year‐old boy presenting with a discharging nodule over the scalp. The report details the clinical presentation, examination findings, and dermoscopic features of furuncular myiasis. To the best of our knowledge, Chrysomya bezziana has never been reported to cause furuncular myiasis. In vivo and ex vivo dermoscopy features help in diagnosis by obviating the need for microscopy.
Efficacy of a Video Education Program Regarding Basic Skin Care in Pediatric Atopic Dermatitis: A Randomized Controlled Trial
Authors: Jungwattanavanit Pornthip , Wananukul Siriwan , Tempark Therdpong , Chantawarangul Karaked , Chatproedprai Susheera
Published: November 2024

Background

Basic skin care education holds the potential to improve clinical outcomes in pediatric atopic dermatitis (AD). However, evidence is lacking on the efficacy of video education for patient guardians in Thailand to reduce AD disease severity.

Objectives

To compare the efficacy of a video education program for guardians of pediatric AD patients versus a control group by assessing the severity score of AD (SCORAD), transepidermal water loss (TEWL), and skin hydration (SH).

Methods

A single‐blinded, randomized controlled trial was conducted at a tertiary hospital from June 2023 to February 2024, involving AD patients aged < 18 years and their guardians. Both groups received standard treatment, and the educational group received an additional video education program. SCORAD, TEWL, SH, pruritus, sleeplessness, and parental/guardian confidence and knowledge accuracy were assessed at enrollment and a 4‐week follow‐up.

Results

Seventy patients (educational:control group, 34:36) with a median age of 3.1 years were enrolled. The groups exhibited no significant demographic or disease severity differences between them. At follow‐up, the educational group showed significant SCORAD improvement compared to the control group (mean difference −10.93 [95% CI −16.92–−4.95]; p < 0.001). SH (mean difference 3.82 [95% CI −2.7–10.33]; p = 0.25) and TEWL (mean difference −1.24 [95% CI −5.72–3.24]; p = 0.58) did not differ significantly.

Conclusions

Video education demonstrated efficacy in significantly reducing SCORAD. While there were improvements in SH and TEWL in patients in the education group, these improvements were not statistically significant. Further investigation with a larger sample size is warranted.

Trial Registration: Thai Clinical Trials Registry (TCTR): TCTR20230524001
The Effect of Mobile Application Follow‐Up on Treatment Compliance and Self‐Care Management in Patients With Hypertension: Randomized Controlled Trial
Authors: Yildirim Keskin Alev , Özpancar Şolpan Nurhan , Değirmenci Hasan
Published: November 2024

Background

Hypertension (HT) is a global health problem. Although there are effective treatment protocols, patients have difficulty in adapting to regular use of drugs, diet, and lifestyle changes. Mobile apps can be a potential alternative for managing HT and improving self‐care behavior.

Purpose

This study aimed to determine the effect of mobile application follow‐up on treatment compliance and self‐care management in patients with HT.

Methods

This randomized controlled trial was conducted in November 2021 and March 2022 with 40 experimental and 40 control group patients with HT. Research data were collected using a patient information form, “Hill‐Bone Hypertension Treatment Compliance Scale (HBHTTCS),” “Hypertension Self‐Care Profile‐Motivation Scale (HTSPMS),” a mobile application program (daily blood pressure, pulse, medication, diet, exercise tracking) uploaded to the mobile phones of the patients, and individual motivational messages.

Results

The mean total score of the HBHTTCS at Week 6 was 14.57 ± 1.89 and the mean total score of the HTSPMS was 78.15 ± 2.05. There was a statistically significant difference in mean total HTSPMS (p = 0.000) and HBHTTCS (p = 0.000) scores and mean scores on medical (p = 0.002) and nutrition (p = 0.002) subscales of HBHTTCS between the first interview (1st‐week follow‐up) and the last interview (6th‐week follow‐up) of patients in the intervention group.

Conclusions

This study showed that mobile application follow‐up increased motivation levels and treatment compliance in patients with HT and resulted in better self‐care. These positive findings indicate importance of integrating mobile applications in the disease management of HT patients.

Trial Registration

ClinicalTrials.gov ID: NCT05334446, https://clinicaltrials.gov/ct2/show/NCT05334446.
European approaches to wastewater reuse regulation: A comparison between Spain, Malta and the Netherlands
Authors: Melchers Sophie
Published: November 2024

Wastewater reuse is encouraged and facilitated by legislation and policy across the EU. A recent example is the EU Regulation 2020/741 on minimum requirements for water reuse. This and other regulatory developments have gone hand in hand with an increase in research in technological innovations that facilitate wastewater reuse, including advanced water treatment technologies. Despite these harmonised developments at the EU level, there appear to be large differences across Member States in the volume of reused water, its sources and the purposes of wastewater reuse. These differences are mirrored in the differences in the regulation of wastewater reuse across the European Union. The present paper has two goals. The first is to provide an overview of the regulation of wastewater reuse in three EU Member States, namely, Spain, Malta and the Netherlands. The comparative analysis reveals evidence of variability in the division of roles and responsibilities, substantive provisions on water reuse, and the allocation of costs. The second objective of the paper is to highlight how, even within the boundaries of the theoretical best practices, national regulation can be heterogenous.
Children's consideration of effort and outcome in reward distribution tasks
Authors: Kim Emily , LoBue Vanessa
Published: November 2024

In the current study, we asked whether children recognize initial inequalities in resources and the effect of these inequalities on subsequent outcomes. We presented 6‐ to 8‐year‐old children with a series of vignettes in which characters’ contribution and effort to a joint task were manipulated, along with the tool they had to complete the task, which affected their relative advantage. Each vignette contained a situation where two children had to help a third person dig pails of sand. In each scenario, the number of pails each child dug, as well as the type of shovel (making it easier or harder for them to dig), was manipulated. Children were asked how rewards should be distributed and who they believed worked harder. We found that children weighed outcome, or the number of pails of sand produced, more heavily than other factors, and only the oldest children showed evidence of considering initial inequalities and effort when making decisions about resource allocation.
Beyond coalition and opposition? The effect of councilwide agreements on legislative voting behaviour in Dutch municipalities
Authors: Vos Thijs , Otjes Simon , van Kalken Lianne , Boogaard Geerten
Published: November 2024

A well‐established finding in the field of legislative behaviour is that parliamentary voting behaviour is nearly always strongly structured by the coalition‐opposition dynamic, even beyond the issues agreed on in the coalition agreement. Can parties break the mould of this coalition‐opposition division? Several Dutch municipal councils work with a councilwide agreement (raadsakkoord) with the specific goal that there is no demarcated coalition and opposition. This could open the political process up for more issue‐driven voting. We test whether council agreements change voting behaviour in the local council. By comparing voting in these municipalities before and after implementing councilwide agreements, we show that these agreements lower the extent to which voting is structured by the coalition‐opposition division. Coalition parties are less likely to vote the same when a councilwide agreement is present. The strength of the coalition‐opposition division depends upon the choices of political parties.
Direct Observations of Intergenerational Visits and Activities at Six Local Recreational Parks in Victoria, Australia
Authors: Levinger Pazit , Dreher Bronwyn , Fearn Marcia , Bauman Adrian , Brusco Natasha K. , Gilbert Andrew , Soh Sze-Ee , Burton Elissa , Hallissey Mairead , Hill Keith D.
Published: November 2024

Local parks offer outdoor spaces for active play; they provide a common attractive space in which grandparents and grandchildren can interact and engage in physical activity. This study investigated how multigenerational active spaces within local parks were being used by older people, their grandchildren, and other age groups. Method: This study was an observational design using direct observations of park visitors over three consecutive months and an intercept survey of a subsample of older visitors in six community parks in Victoria, Australia. The number of visitors, activity interaction, type of accompaniment (e.g., intergenerational, family, group), and physical activity level were recorded and reported descriptively. Results: A total of 5,373 visitors were observed with 43.3% (n = 2,327) children and 10% (n = 537) older people. Most visitors attended with company (55.9%–97.7%), with older people’s most common accompaniments being intergenerational groups (n = 164, 30.5%). Within the observed intergenerational instances, 35% were older people and 45.1% children. Most people from all age groups were observed to be physically active (≥78%). Survey respondents (n = 48) reported attending the park alone (47.9%) or with company (e.g., 22.9% grandchildren, 12.5% a partner/friend). Approximately a third of respondents reported exercising with their grandchildren in the designated space. Discussion: A large proportion of older visitors were observed with intergenerational accompaniment in local parks, with most grandparents and their grandchildren observed to be physically active. The active spaces, which include multigenerational outdoor equipment, may be an attractive setting for both children and older adults to foster intergenerational interaction and engagement in physical activity.
Social and Emotional Learning in Finnish Physical Education Teacher Education
Authors: Mäkinen Tommi , Virtanen Anne , Kostiainen Emma
Published: November 2024

Purpose: Teachers’ social and emotional learning (SEL) skills play a central role in physical education to promote holistic youth development and physical activity. The purpose of this study was to explore what SEL skills Finnish physical education student teachers learned during their final study year at university and how they described the meaning of SEL in part of their teacherhood. Method: Data were collected from a questionnaire for four annual courses of Finnish physical education student teachers (n125) and written teaching philosophies (n12). Results: Students reported learning many different SEL skills during their final year. Most learning experiences were reported in self-awareness skills and relationships skills. SEL was also described as (a) a tool for better teaching, (b) a basis for human perception, and (c) changing the way they view their teacherhood. Discussion/Conclusion: The findings indicated that students place a high value on learning SEL skills and that SEL is central to their overall view of physical education.
Oncologic outcomes of incidental serous tubal intraepithelial carcinoma and associated high-grade serous carcinoma in high-risk patients undergoing risk-reducing surgery
Authors: Aoun Eliane , Lawson Barrett , Awujo Chika , Nebgen Denise , Soletsky Beth R , Chisholm Gary B , Lu Karen H , Nitecki Wilke Roni
Published: November 2024

Objective

We sought to describe the oncologic outcomes of isolated serous tubal intraepithelial carcinomas compared to an intraepithelial carcinoma found concurrently with microscopic high-grade serous carcinoma among patients with hereditary predisposition to ovarian cancer who underwent risk-reducing surgery.

Methods

We conducted a retrospective analysis of 32 high-risk patients withBRCA1, BRCA2, RAD51C/D, BRIP1,orPALB2pathogenic variants who were diagnosed with either isolated serous tubal intraepithelial carcinoma or concurrent serous tubal intraepithelial carcinoma and microscopic high-grade serous carcinoma following risk-reducing surgery between January 2006 and December 2023. Our population included patients who underwent surgery at our institution as well as those who had surgery elsewhere, but sought second opinions, follow-up care, or treatment at our institution. Data were gathered from medical and pathologic records, and pathologic specimens were re-reviewed by a gynecologic pathologist. Standard statistical methods were used to describe oncologic outcomes per group.

Results

Among 32 patients in the cohort, we found that 68.7% had a pathologic diagnosis of an incidental serous tubal intraepithelial carcinoma, while 31.3% had a pathologic diagnosis of microscopic high-grade serous carcinoma with associated serous tubal intraepithelial carcinoma. Notably, two patients (9%) with isolated serous tubal intraepithelial carcinoma developed primary peritoneal carcinoma within a median of 29 months after surgery. One-third of patients with microscopic cancer experienced recurrence despite receiving standard staging surgery and chemotherapy for early-stage disease. Most of the patients in the cohort were older at the time of risk-reducing surgery than recommended for their pathologic variant.

Conclusions

The study supports the critical need for timely risk-reducing surgery in high-risk populations, as well as a comprehensive pathologic examination along with vigilant post-operative surveillance. Consensus guidelines for management of serous tubal intraepithelial carcinoma are necessary to identify a group of patients at higher risk of progression to primary peritoneal carcinoma and optimize patient care.
Tmax >4 s volume predicts stroke recurrence in symptomatic intracranial atherosclerotic stenosis with optimal medical treatment
Authors: Yu Ying , Yu Junchao , Hou Zhikai , Chiu Tse-cheng , Liu Xiaobo , Pan Yuesong , Yan Long , Fu Weilun , Jia BaiXue , Lui WT , Wang Yongjun , Wang Rong , Miao Zhongrong , Lou Xin , Ma Ning
Published: November 2024

Background

The time to maximum (Tmax) profile based on computed tomography perfusion (CTP) provides a quantitative assessment of cerebral hemodynamic compromise. We aimed to delineate the Tmax profile in stroke patients with symptomatic intracranial atherosclerotic stenosis (ICAS) and to investigate its predictive role in stroke recurrence after optimal medical treatment.

Methods

Consecutive patients with ischemic stroke within 30 days attributed to 50%–99% ICAS were prospectively enrolled. Baseline tissue volume at different perfusion parameter thresholds based on CTP was automatically calculated using the Rapid Processing of Perfusion and Diffusion (RAPID) software. All patients received optimal medical treatment. The primary outcome was a composite of stroke in the territory of qualifying artery or vascular death within 1 year.

Results

Among 204 patients with symptomatic ICAS, the median volume of Tmax >4 s, Tmax >6 s, and relative cerebral blood flow (rCBF) <30% were 61 mL, 0 mL, and 0 mL, respectively. The 1 year rate of primary outcome was 16.2% (33/204). Tmax >4 s volume was significantly associated with the primary outcome (per 10 mL increase, adjusted hazard ratio (HR), 1.028 (1.008–1.049), P=0.005). The optimal cut-off value of Tmax >4 s volume for predicting the primary outcome was 83 mL. Patients with Tmax >4 s volume >83 mL had a higher risk of the 1 year primary outcome than those with Tmax >4 s volume ≤83 mL (adjusted HR, 7.346 (3.012–17.871), P<0.001), after adjusting for degree of stenosis and stroke mechanisms.

Conclusion

Tmax >4 s volume is a promising perfusion parameter to define hemodynamic compromise in patients with symptomatic ICAS. Patients with a larger volume of Tmax >4 s are likely to have a higher risk of stroke recurrence despite optimal medical treatment.
Validation of a phase-field approach for contact line hysteresis against a sloshing droplet case
Authors: Bodziony Francisco , Govže Viktor , Dupuy Eva-Marie , Marschall Holger
Published: November 2024

Understanding liquid propellants behavior in microgravity conditions is critical for efficient spacecraft design. For a number of operations, ranging from engine restart to orbital propellant storage and transfer, insight is needed to characterize capillary-dominated flows. In such conditions, surface tension and wetting properties, including contact angle hysteresis, can greatly impact the fluid’s behavior and therefore spacecraft performance. Using experimental data from ESA Propulsion Laboratory, a contact line model for the Cahn–Hilliard phase-field method is validated. The case studied is that of a droplet confined between two oscillating plates, which aims to isolate and observe contact angle-driven physics, limiting the effect of gravity on the flow in a simple and reproducible way on ground. The contact line model allows for the prediction of contact line motion without requiring the computation of dynamic contact angles or contact line velocities, thus simplifying implementation and reducing computational overhead. For the validation, contact line pinning and motion under varying oscillation frequencies is investigated. Specifically, the length between the rear and front contact line edges, as well as the shape of the sloshing droplet are compared. The results show good agreement between simulations and experimental data, confirming the model’s accuracy in predicting contact line behavior and pinning.
Bridging IoT Protocols with the Web of Things: A Path to Enhanced Interoperability
Authors: Xun Lei
Published: November 2024

Nowadays, the Internet of Things (IoT) is reshaping numerous application domains. Amidst the different communication protocols currently available (MQTT, CoAP, AMQP, DPWS, etc.) and the abundance of management platforms, the IoT domain has stumbled into vertical silos of proprietary systems hindering interoperability. Within this intricate and fragmented ecosystem, the need for an intelligent and scalable architecture promoting interoperability becomes imperative to maximize the potential of IoT. This paper introduces a system designed to enhance the convergence of IoT protocols (e.g., MQTT, CoAP, AMQP, etc.) with the Web of Things (WoT) paradigm. Our proposed gateway-based solution integrates two systems: Stack4Things (S4T) and Data eXchange Mediator Synthesizer (DeXMS). The role of the latter is to adapt, at the gateway level, the IoT protocols and expose the resources/functionalities of the IoT devices as RESTful APIs using HTTP. Meanwhile, the former (i.e., S4T), leveraging its Dynamic DNS system, ensures that these RESTful resources (exposed at the gateway) are accessible over the Web using publicly routable Uniform Resource Locators (URLs) even when the gateway is deployed behind networking middle boxes (e.g., NATs and firewalls).
Cloud Platform Business Scenario Modeling Based on Multi-Model Fusion Recommendation Algorithm
Authors: Li Hui , Zhang Guanyu , Liu Haibin , Feng Junyi
Published: November 2024

In the era of cloud computing, businesses are increasingly relying on cloud platforms to streamline their operations and deliver services efficiently. Recommendation systems play a pivotal role in suggesting suitable services and resources to enhance user experience and optimize resource allocation. This paper presents a novel approach, the Multi-Model Fusion Recommendation Algorithm (MMFRA), which integrates multiple recommendation models using advanced fusion techniques to enhance the accuracy of recommendations in cloud platform business scenarios. The implementation process of MMFRA involves combining diverse recommendation models, such as collaborative filtering, content-based filtering, and matrix factorization, into a unified framework that leverages their strengths while mitigating individual limitations. This fusion process is designed to achieve higher precision in service recommendations by considering various aspects of user behavior and preferences. Through a comprehensive evaluation in a simulated cloud platform environment, MMFRA demonstrates superior performance in terms of recommendation accuracy and user satisfaction. The proposed algorithm offers significant potential for enhancing the effectiveness of cloud platform services, ultimately benefiting both service providers and users.
Cloud Network Collaborative SFC Deployment Under Heterogeneous Resource Of Power White Box Network
Authors: Zhang Rui , Miao WeiWei , Zhang Zhen , Teng ChangZhi , Zeng Zeng , Lin Peng
Published: November 2024

The construction of new electric power systems has led to a multiplication in the number of access nodes for electric power IoT information communication, accompanied by a deepening trend in business cloudification. However, due to the insufficient resource linkage and regulation capabilities of the electric power communication network on the cloud side, network side, and edge side, coupled with the lack of a convenient and unified cloud-network resource convergence and control mechanism, the existing electric power communication architecture is gradually finding it difficult to fully meet the demand for deterministic multi-service bearer. Therefore, it is necessary to evolve the original network equipment within the network toward a white box model, opening up interfaces for fine-grained sensing and full-area control, in order to provide more accurate and controllable network transmission services. In this paper, we first propose a cloud-network cooperative resource scheduling architecture for the electric power white box network. This architecture establishes a bearer network to achieve high consistency and cooperativeness of cloud-side end computing power through white box switches, uniformly schedules the global resources of the cloud-network convergence network, and improves the network service quality between cloud-side and side-side. Furthermore, we design a multi-dimensional re-source scheduling method for cloud-network synergy in the electric power white box network. This involves constructing a white box network virtualized heterogeneous resource (VHR) model and a heterogeneous resource control flow (HRCF) model. We transform the problem of merged deployment of service function chains (SFCs) into an SFC merger deployment problem by jointly controlling heterogeneous information, communication, storage, and arithmetic resources, along with the white box switch-specific pipelining resources in the white box network. We then carry out merger optimization of the same kind of function chains. Additionally, we propose a G-GS algorithm based on heuristic methods. Simulation results demonstrate that the method presented in this paper can significantly reduce the cost consumption of white box pipeline resources in the electric power white box network, thereby reducing the processing delay of SFC and improving the quality of electric power service bearing.
A Cloud-Based Breast Cancer Detection with Optimized Self-Attenuated Deep CNN
Authors: Lokhande Dipali , Rajeswari K.
Published: November 2024

The life of humans faces several disasters that sometimes may be deadly and cause severe effects on future endeavors. One major cause of lifestyle change is the several types of disease among which some are unrecognizable, and some are untreatable. Cancer is one of the chronic diseases that occur due to the uncontrollable cell division and in the category of cancer, breast cancer is the second disease with the lowest survival rate throughout the world. Prediction of breast cancer at its early stage enhances the survival rate. To maximize the survival rate and a healthy environment, researches on various techniques of breast cancer prediction have emerged. Though these researches have paved a better way for prediction, they also had some drawbacks that minimized the efficacy of the research outcomes. To overcome all these drawbacks, the proposed self-attention-based deep Convolutional Neural Network (Self-attention DCNN) is utilized and the classifier’s performance is enhanced with the Smack Echolocation Optimization (SELO). In addition, a better segmentation method called SELO-optimized ensemble masked Region-based CNN (SELO-mask RCNN) is introduced in the research that segments the region of interest to incorporate the fine-grained segmentation as well as the semantic understanding of the image. The performance of research is evaluated with [Formula: see text]-measure, Precision, and Recall that achieved 98.27%, 99.21%, and 98.99%, respectively.
Toward Complex-query Referring Image Segmentation: A Novel Benchmark
Authors: Ji Wei , Li Li , Fei Hao , Liu Xiangyan , Yang Xun , Li Juncheng , Zimmermann Roger
Published: November 2024

Referring Image Segmentation (RIS) has been extensively studied over the past decade, leading to the development of advanced algorithms. However, there has been a lack of research investigating how existing algorithms should be benchmarked with complex language queries, which include more informative descriptions of surrounding objects and backgrounds (e.g.,
the black car
vs.
the black car is parking on the road and beside the bus
). Given the significant improvement in the semantic understanding capability of large pre-trained models, it is crucial to take a step further in RIS by incorporating complex language that resembles real-world applications. To close this gap, building upon the existing RefCOCO and Visual Genome datasets, we propose a new RIS benchmark with complex queries, namely
RIS-CQ
. The RIS-CQ dataset is of high quality and large scale, which challenges the existing RIS with enriched, specific, and informative queries, and enables a more realistic scenario of RIS research. Besides, we present a niche targeting method to better task the RIS-CQ, called Dual-Modality Graph Alignment (
DuMoGa
) model, which outperforms a series of RIS methods. To provide a valuable foundation for future advancements in the field of RIS with complex queries, we release the datasets, pre-processing and synthetic scripts, and the algorithm implementations at
https://github.com/lili0415/DuMoGa
.
Tiaozhuan: A General and Efficient Indirect Branch Optimization for Binary Translation
Authors: Li Xinyu , Guo Guangyao , Lan Yanzhi , Xue Feng , Han Chenji , Niu Gen , Zhang Fuxin
Published: November 2024

Binary translation enables transparent execution, analysis, and modification of the binary program, serving as a core technology that facilitates instruction set emulation, cross-platform compatibility of software, and program instrumentation. Handling indirect branch instructions is widely recognized as a significant performance bottleneck in binary translation. While the target of direct branch can be determined during the translation phase, indirect branch requires a run-time lookup from the guest program counter to the host program counter, significantly influencing the performance of translator. Although several methods have been proposed to accelerate this process, each guest indirect branch instruction still translates into approximately ten host instructions, resulting in considerable overhead.

This paper introduces Tiaozhuan, which addresses this issue by employing two optimization schemes. Firstly,
Full Address Mapping
uses a larger address space to store address mappings from guest to host, effectively reducing the number of instructions required to lookup the target of an indirect branch. Secondly,
Exception Assisted Branch Elimination
further eliminates branch instructions that check target correctness of targets in the lookup process. These two approaches enable indirect branches target lookup to be completed within 1-2 instructions, noticeably decreasing the overhead of indirect branches. Compared to state-of-the-art mechanisms, the SPEC CPU2006 benchmark suite showed a reduction in the number of instructions by an average of 4.2%, with the highest observed performance improvement reaching 19.4% and an average increase of 3.9%.
A Renaissance of Atoll Ecology
Authors: Steibl Sebastian , Bunbury Nancy , Young Hillary S. , Russell James C.
Published: November 2024

The approximately 320 atolls of the world, scattered across the tropical oceanic basins, constitute a unique type of ecosystem in that they are each an integrated unit consisting of island, coral reef, and lagoon components. Atolls have a complex geology, ecology, and biogeography, which can be fully appreciated only by transcending the classic boundary thinking of marine and terrestrial realms. The atolls we observe today were shaped by Quaternary sea-level fluctuations, which imposed strong environmental filters on their communities. As entirely biogenic, reef-borne structures, the islands of atolls depend upon marine productivity, which catalyzes island community assembly. Island species communities exist in complex dynamic equilibria with the surrounding oceanographic conditions. Energy fluxes and element cycles of the atoll system readily cross habitat boundaries and create a productive, diverse, and biomass-rich ecosystem on land and underwater. Past human disturbances and future global change put atolls at the forefront of conservation and ecological restoration.
Cobalt Ferrite-Modified Nickel Foam as Electrochemical Uric Acid Sensor Towards Biological and Food Sensing Applications
Authors: John Josfel Flora , Dhinasekaran Durgalakshmi , Subashchandran Shanthi
Published: November 2024

Ferrites are effectively used in electrochemical uric acid (UA) sensing applications. Herein, we synthesised cobalt ferrite (CoFe2O4) nanoparticles synthesised by one step solution combustion method. The prepared CoFe2O4 was coated on nickel foam (NF) substrate to fabricate the electrode and tested using phosphate buffer saline (PBS). The small crystallite size of 14 nm as well as the large area of active sites of 0.139 cm2 contributed towards the enhanced sensitivity of 0.735 mA.mM−1 cm−2. The limit of detection (LOD) of CoFe2O4@NF sensor is 26.24 μM. The UA sensing occurs by an adsorption-controlled kinetics by electrostatic interaction at a pH ∼7.2 where UA anion is negatively charge while CoFe2O4 surface is positively charged and it displays a quasi-reversible reaction. Additionally, the repeatability, selectivity, reproducibility of the UA sensor and the electrode kinetics were investigated. The real-time application of CoFe2O4@NF was validated using spot-urine, commercial milk and Barracuda fish samples, which show recovery percentage between 99.5% and 101.8%. The shelf-life of the CoFe2O4@NF electrode is observed to be 28 days. Hence, this highly sensitive cobalt ferrite UA sensor can be used for clinical diagnosis of hyperuricemia and food safety purposes.
The Effect of Metallographic Preparation on the Surface Characteristics and Corrosion Behaviour of Ti-6Al-4V Alloy in Simulated Physiological Solutions
Authors: Milošev Ingrid , Sačer Denis , Kapun Barbara , Rodič Peter
Published: November 2024

This study aimed to determine the effect of surface metallographic preparation (grinding, diamond polishing, and chemo-mechanical polishing using silica and hydrogen peroxide) on the surface roughness, morphology, chemical composition, and electrochemical behaviour of Ti-6Al-4V alloy. Roughness decreases from ca. 0.2 μm to 0.02 μm from grinding to polishing. A typical α+β microstructure can be observed only after chemo-mechanical polishing. The average composition of ca. 6 wt% Al, 4 wt% V, and rest Ti was determined regardless of the surface preparation. X-ray photoelectron spectroscopy revealed that the thickness of the oxide layer formed on chemo-mechanical polished samples is half that of ground samples. The metallographic preparation largely affects the corrosion behaviour of Ti-6Al-4V, which was investigated using electrochemical impedance spectroscopy and potentiodynamic polarisation in 0.9 wt% NaCl and artificial saliva at 37°C. At the open circuit potential, the chemo-mechanically polished Ti-6Al-4 samples showed superior corrosion resistance over ground samples. At potentials over 2.5 V vs Ag/AgCl, increased current densities were noted for chemo-mechanically polished samples, presumably related to the oxidation to a thicker oxide.
The Annealing Temperature Effect Enhances the Structural and Optical Parameters of Bi2Te3 Thermally Evaporated Thin Films
Authors: Salwa A. S. , Imam Amal M. , Satti Amira A. E.
Published: November 2024

The current work investigates the influence of the annealing temperature (373, 473 K) on the structural and optical properties of Bi2Te3 thin films produced by the thermal evaporation technique. The crystal structure of samples is examined using an X-ray diffraction, indicating that Bi2Te3 thin films have a Rhombohedral structure with space group R-3m. The crystallite size (D) increased from 10.85 to 14.46 nm by increasing the annealing temperature. Additionally, increasing the annealing temperature reduces the micro-strain and the dislocation density from (3.33 × 10−3 to 2.5 × 10−3) and (8.49 × 1015 to 4.78 × 1015)

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respectively. These micro-strain and dislocation density reductions refer to the crystallinity enhancement of sample Bi2Te3 thin films. The transmittance and reflectance spectra were measured using an Fourier transform infrared spectrometer. All samples reveal direct and indirect transition types and both direct and indirect optical energy gap decreased with increased annealing temperature from (0.325 to 0.29 eV) and (0.24 to 0.274 eV), respectively. From transmittance and reflectance data, the refractive index is calculated. These results reveal the refractive index decreasing as temperature annealing increased from (2.45–1.79) at 3250 nm. Other optical parameters such as absorption index, dielectric constant, energy loss function, and optical conductivity were estimated.
A bovine model of hypoxia-induced pulmonary hypertension reveals a gradient of immune and matrisome response with a complement signature found in circulation
Authors: Williams Jason , Iheagwam Franklyn N. , Maroney Sean P. , Schmitt Lauren R. , Brown R. Dale , Krafsur Greta M. , Frid Maria G. , McCabe Maxwell C. , Gandjeva Aneta , Williams Kurt J. , Luyendyk James P. , Saviola Anthony J. , Tuder Rubin M. , Stenmark Kurt , Hansen Kirk C.
Published: November 2024

Extensive immune cell infiltration and matrisome alterations associated with hypoxia-induced pulmonary hypertension in a large mammal model. Matrisome components correlate with increased resistance to identify candidate alterations that drive biomechanical manifestations of the disease.
The HIF2α-dependent upregulation of SETDB1 facilitates hypoxia-induced functional and phenotypical changes of pulmonary microvascular endothelial cells
Authors: Zhou Yin , Yang Kai , Zhang Zizhou , Wei Feng , Chen Lishi , Luo Dongling , Yang Ziyang , Zhao Kaixun , Xie Nanshan , Li Wenrui , Liang Shuxin , Xiong Mingmei , Tang Haiyang , Wang Jian , Zhang Caojin
Published: November 2024

Abnormal histone modification plays vital role in pulmonary hypertension (PH). This study reports the regulation and role of a histone 3 lysine 9 (H3K9) methyltransferase, SETDB1, in primarily cultured rat pulmonary microvascular endothelial cells (PMVECs). Hypoxia induces significant upregulation of SETDB1 at both mRNA and protein levels, in a HIF2α-dependent manner. The hypoxic upregulation of SETDB1 leads to significant apoptosis, senescence, and endothelial-to-mesenchymal transition in PMVECs. Treatment of a specific inhibitor of histone methyltransferase, Chaetocin, effectively attenuates the disease pathogenesis of PH rat model induced by SU5416/hypoxia.
Post-exercise hot-water immersion is not effective for ribosome biogenesis in rat skeletal muscle
Authors: Kotani Takaya , Tamura Yuki , Kouzaki Karina , Sasaki Kazushige , Nakazato Koichi
Published: November 2024

Ribosome biogenesis is crucial in resistance exercise (RE)-induced skeletal muscle hypertrophy. This study examined the effects of hot-water immersion (HWI) on ribosome biogenesis after RE. HWI and post-exercise HWI increased c- Myc and transcription initiation factor-IA mRNA but did not alter ribosomal RNA transcription or ribosomal protein content. HWI tended to decrease 28S and 18S ribosomal RNA. These findings suggest that HWI, as a recovery strategy, does not effectively promote ribosome biogenesis or muscle protein synthesis.
Comparative analysis of acute eccentric contraction-induced changes to the skeletal muscle transcriptome in young and aged mice and humans
Authors: Boykin Jake R. , Steiner Jennifer L. , Laskin Grant R. , Roberts Michael D. , Vied Cynthia , Willis Craig R. G. , Etheridge Timothy , Gordon Bradley S.
Published: November 2024

Acute eccentric muscle contractions in rodents are used to model resistance exercise in young and aged humans, including changes to the muscle transcriptome. This work defines the utility of the rodent model at mimicking the transcriptional features observed in young and aged humans.
Chest Tube Clearance Strategies Versus Conventional Chest Tubes After Cardiac Surgery
Authors: Chan Veronica F. , Vervoort Dominique , Tam Derrick Y. , Fremes Stephen E.
Published: November 2024

Standard chest tubes (CTs) used to drain retained blood can become occluded from blood clots, leading to ineffective drainage and postoperative complications such as cardiac tamponade. Chest tube clearance strategies (CTCSs) were developed to improve CT patency. Our meta‐analysis compared the safety and efficacy of CTCS versus CT following cardiac surgery. The PubMed/MEDLINE, Embase, Web of Science, and Scopus databases were searched from 1946 to 2023 for studies that compared CTCS to CT. Two investigators independently reviewed, screened, extracted, and assessed the data prior to performing a random effects meta‐analysis using R. The primary outcome was re‐exploration and the secondary outcomes were retained blood syndrome, mortality, blood products, stroke, cardiac arrest, atrial fibrillation, ventilation time, intensive care unit (ICU) time, hospital length of stay, and chest drainage. Five studies (2288 patients) were included. There were two clinical trials (n = 620) and three observational studies (1668 patients). Compared to CT, CTCS had a significant reduction of postoperative atrial fibrillation (risk ratio (RR) 0.80, 95% CI 0.70 to 0.92, I2 = 17%, p < 0.01). There was no significant difference in re‐exploration, retained blood syndrome, hospital length of stay, and ICU length of stay. However, with the addition of four unmatched studies (n = 2583), CTCS was associated with a significant reduction in re‐exploration (RR 0.52, 95% CI 0.37 to 0.73, I2 = 34%, p < 0.01), retained blood syndrome (RR 0.71, 95% CI 0.53 to 0.95, I2 = 72%, p = 0.02), hospital length of stay (mean difference (MD) −0.40, 95% CI −0.78 to −0.01, I2 = 49%, p = 0.04), and chest drainage (MD 0.80, 95% CI 0.70 to 0.92, I2 = 17%, p < 0.01). Drawing from results including the unmatched studies, CTCSs are associated with fewer postoperative complications compared to CT. This was achieved without major differences in chest drainage, supporting the important role of preventing even small accumulations of blood in the pericardial space.
Supplemental Table 4 from Targeting YES1 Disrupts Mitotic Fidelity and Potentiates the Response to Taxanes in Triple-Negative Breast Cancer
Authors: Piemonte Katrina M. , Ingles Natasha N. , Weber-Bonk Kristen L. , Valentine Mitchell J. , Majmudar Parth R. , Singh Salendra , Keri Ruth A.
Published: November 2024

Overlapping DEGs in YES1i
Supplementary Table S7 from KHSRP Stabilizes m6A-Modified Transcripts to Activate FAK Signaling and Promote Pancreatic Ductal Adenocarcinoma Progression
Authors: Xu Zilan , Zhou Yifan , Liu Shaoqiu , Zhao Hongzhe , Chen Ziming , Li Rui , Li Mei , Huang Xudong , Deng Shuang , Zeng Lingxing , Zhao Sihan , Zhang Shaoping , He Xiaowei , Liu Ji , Xue Chunling , Bai Ruihong , Zhuang Lisha , Zhou Quanbo , Chen Rufu , Lin Dongxin , Zheng Jian , Zhang Jialiang
Published: November 2024

Supplementary Table S7
Supplementary Table S4 from KHSRP Stabilizes m6A-Modified Transcripts to Activate FAK Signaling and Promote Pancreatic Ductal Adenocarcinoma Progression
Authors: Xu Zilan , Zhou Yifan , Liu Shaoqiu , Zhao Hongzhe , Chen Ziming , Li Rui , Li Mei , Huang Xudong , Deng Shuang , Zeng Lingxing , Zhao Sihan , Zhang Shaoping , He Xiaowei , Liu Ji , Xue Chunling , Bai Ruihong , Zhuang Lisha , Zhou Quanbo , Chen Rufu , Lin Dongxin , Zheng Jian , Zhang Jialiang
Published: November 2024

Supplementary Table S4
Supplemental Figure 7 from Targeting YES1 Disrupts Mitotic Fidelity and Potentiates the Response to Taxanes in Triple-Negative Breast Cancer
Authors: Piemonte Katrina M. , Ingles Natasha N. , Weber-Bonk Kristen L. , Valentine Mitchell J. , Majmudar Parth R. , Singh Salendra , Keri Ruth A.
Published: November 2024

YES1 inhibition re-sensitizes paclitaxel-resistant SUM159 cells, in vitro.
Supplemental Figure 3 from Targeting YES1 Disrupts Mitotic Fidelity and Potentiates the Response to Taxanes in Triple-Negative Breast Cancer
Authors: Piemonte Katrina M. , Ingles Natasha N. , Weber-Bonk Kristen L. , Valentine Mitchell J. , Majmudar Parth R. , Singh Salendra , Keri Ruth A.
Published: November 2024

YES1 silencing alters mitotic gene expression and cell cycle progression in SUM159 cells.