bluuebunny/crossref_metadata_2025 huggingface dataset:
Academic literacy development and professional identity construction in non-native English-speaking novice English language teachers
Authors: Chen Mo , Zhang Wenli , Zheng Qun
Published: August 2023

Studies examining students’ academic literacy development have received increasing attention in the past two decades, with exponential growth in the literature since 2010. Despite this, there have been relatively few empirical studies on novice teachers’ academic literacy learning process and the construction of teachers’ professional identities. To address this issue, this study employed a longitudinal narrative inquiry to trace and evaluate the professional identity construction of two Chinese novice language teachers as they developed academic literacy in their master’s and doctoral programs in the United States. The study adopted a Community of Practice (CoP) framework and drew upon various data sources, such as both novice teachers’ coursework, reflection journals, statements of teaching philosophy, and other supplementary documents, to evaluate how each participant was socially engaged (or disengaged) in a new language education community and how they developed professional identities as language teachers in this process. The findings indicate that the pedagogical knowledge and theories acquired by both participants during their graduate studies informed their teaching methods and promoted their development of a researcher-teacher identity. In addition, the longitudinal data allowed for tracking changes in both participants’ self-efficacy and emotions. While the stories of both novice teachers described the evolution of their teaching beliefs throughout their graduate studies, their narratives also highlighted a lack of micropolitical literacy training at the graduate level. This study contributes to our understanding of the connection between academic literacy development and the formation of teacher professional identity by shedding light on novice language teachers with a non-native English-speaking background. The implications for future research are also provided.
Examining the dimensionality of morphological knowledge and morphological awareness and their effects on second language vocabulary knowledge
Authors: Wang Tuoxiong , Zhang Haomin
Published: August 2023

Morphological knowledge and morphological awareness are multidimensional and both have been confirmed to make important contributions to vocabulary knowledge. However, the extant literature has not made a clear demarcation between morphological knowledge and morphological awareness. The current study examined the underlying components of morphological knowledge and morphological awareness as well as their effects on vocabulary knowledge. The performance of 226 tenth- and eleventh-graders on five tasks was investigated using confirmatory factor analysis and structural equation modeling. Results demonstrated that morphological knowledge and morphological awareness were two distinct constructs. In regard to the direct and indirect effects between morphological knowledge and vocabulary, it was indicated that morphological knowledge made a significant indirect effect on vocabulary knowledge through morphological awareness. However, the direct effect of morphological knowledge on vocabulary knowledge was not significant. Findings from the current study have important implications to adolescent EFL students’ vocabulary instruction and research.
Change processes during intensive day programme treatment for adolescent anorexia nervosa: a dyadic interview analysis of adolescent and parent views
Authors: Colla Amy , Baudinet Julian , Cavenagh Penny , Senra Hugo , Goddard Elizabeth
Published: August 2023

Background

Day programmes for adolescent anorexia nervosa (AN) can function as an alternative to inpatient admissions and/or an increase in outpatient treatment intensity. Processes of change during treatment for AN are currently poorly understood. This study aimed to explore how adolescents with AN and their parents understood the helpful and unhelpful factors and processes that impacted them during day programme treatment.

Method

A critical realist paradigm was used to qualitatively explore the views of 16 participants. Participants were recruited from the Intensive Treatment Programme (ITP) at the Maudsley Center for Child and Adolescent Eating Disorders (MCCAED) at the end of treatment. Dyadic Interview Analysis (DIA) was used to compare and contrast the narratives of the seven adolescent–parent pairs after two inductive reflexive thematic analyses were conducted for the group of eight adolescents and the group of eight parents separately.

Results

Eight subthemes across three themes were identified: 1) “Like me she didn't feel so alone anymore”—families connect with staff, peers, and each other; 2) “You have to eat because ITP say so”—the programme provides families with containment through its structure and authority; and 3) “I found that I was using the skills I learnt there like in multiple aspects of my life, not just around food”—families take in new ideas and generalize these into their lives. These interconnected themes generated hope and change. However, helpful elements individually could be unhelpful if one or more of the other factors were missing. For example, staff firmness, which participants often found helpful (theme two), could be experienced as harshness when adolescents did not feel related to as individuals (theme one).

Conclusion

The findings can be conceptualized within recent descriptions regarding the therapeutic change, including epistemic trust and mentalization. Treatment characteristics, such as intensity and containment, as well as illness-specific factors and processes, such as control and collaboration, the role of peer support, and the potential for family members to experience the impact of the adolescent's AN and treatment non-response as traumatic, are equally important to consider.
People behavioral during health information searching in COVID-19 era: a review
Authors: Alzghaibi Haitham
Published: August 2023

Background

The COVID-19 pandemic has led to an increase in health information-seeking behavior (HISB) on the Internet.

Objective

This review aims to identify and synthesize the available evidence on health information-seeking behavior on the Internet during and after the COVID-19 pandemic.

Methods

Electronic search of databases was conducted on PubMed, ScienceDirect, Scopus, and Taylor and Francis Online to identify relevant articles. Studies that examined health information-seeking behavior on the Internet during or after the COVID-19 pandemic were included. Data from the included studies were subjected to a thematic analysis.

Results

A total of 355 articles were identified in the initial database search. After screening, 15 articles were included in this review paper, with a population of 33,326. Search engines, social media, and news portals were the most commonly used information sources. The primary motivators for seeking health information online were curiosity, catching up with updated information, and paying attention to the COVID-19 transmission. Participants’ satisfaction with the information obtained online was positive in most studies. The online query for all items related to COVID-19 and health increased during the pandemic. The most searched topics were symptoms of COVID-19, restrictions, current prevalence/spread of COVID-19, and preventive measures. Higher scores in digital health literacy (DHL) were associated with a well-established and effective health information-seeking behavior.

Conclusion

The findings of this review provide insight into the patterns and trends of health information-seeking behavior on the Internet during and after the COVID-19 pandemic. The results suggest that search engines, social media, and news portals remain key sources of information during the pandemic. It also assessed the relationship between the DHL and the HISB and found that having a good DHL generally meant a good HISB.
A novel strategy to avoid sensitivity loss in pooled testing for SARS-CoV-2 surveillance: validation using nasopharyngeal swab and saliva samples
Authors: Millward Georgia G. , Popelka Shane M. , Gutierrez Anthony G. , Kowallis William J. , von Tersch Robert L. , Yerramilli Subrahmanyam V.
Published: August 2023

At the peak of the COVID-19 pandemic, pooled surveillance strategies were employed to alleviate the overwhelming demand for clinical testing facilities. A major drawback of most pooled-testing methods is the dilution of positive samples, which leads to a loss of detection sensitivity and the potential for false negatives. We developed a novel pooling strategy that compensates for the initial dilution with an appropriate concentration during nucleic acid extraction and real-time PCR. We demonstrated the proof of principle using laboratory-created 10-sample pools with one positive and corresponding individual positive samples by spiking a known amount of heat-inactivated SARS-CoV-2 into viral transport medium (VTM) or pooled negative saliva. No Ct difference was observed between a 10-sample pool with one positive vs. the corresponding individually analyzed positive sample by this method, suggesting that there is no detectable loss of sensitivity. We further validated this approach by using nasopharyngeal swab (NPS) specimens and showed that there is no loss of sensitivity. Serial dilutions of the virus were spiked into VTM and pooled with negative saliva in simulated 10-sample pools containing one positive to determine the LOD and process efficiency of this pooling methodology. The LOD of this approach was 10 copies/PCR, and the process efficiencies are ~95%−103% for N1 and ~87%−98% for N2 with samples in different matrices and with two different master mixes tested. Relative to TaqPath 1-step master mix, the TaqMan Fast Virus 1-Step master mix showed better sensitivity for the N2 assay, while the N1 assay showed no Ct difference. Our pooled testing strategy can facilitate large-scale, cost-effective SARS-CoV-2 surveillance screening and maintain the same level of sensitivity when analyzed individually or in a pool. This approach is highly relevant for public health surveillance efforts aimed at mitigating SARS-CoV-2 spread.
An investigation of what protective individual- and community-level factors are associated with life satisfaction in middle-aged and older family carers in Ireland
Authors: McGarrigle Christine A. , Ward Mark , Kenny Rose Anne
Published: August 2023

Background

Family care plays an essential role in providing care in society. However, caring can cause stress, and mental and physical responses to caring vary widely. Different outcomes for carers may reflect different approaches or adaptability to caring and their ability to maintain or recover their mental health and wellbeing following an adverse event (psychosocial resilience). We aim to identify factors that may promote psychosocial resilience, conceptualized as maintaining or recovering subjective wellbeing and operationalized as satisfaction with life, among carers.

Methods

Data were from 6 Waves (2009–2021) of The Irish Longitudinal Study on Aging (TILDA), a prospective biennial nationally representative longitudinal study of older adults aged ≥50 in Ireland. Family caregiving was assessed in Waves 3–6. Participants were asked if they cared for someone, their relationship to the recipient, and the number of hours per week that they provided care. We used growth mixture modeling to identify latent trajectories of satisfaction with life (SWL) before and after caring was initiated. Regression modeling was then used to identify protective factors (at the individual, family, and community levels) associated with resilient trajectories.

Results

Overall, 731 (12.2%) participants became carers during follow-up. We identified three trajectories in SWL in carers following initiation of caring, namely, Resilient-Stable (81%), Resilient-Recovery (12%), and Non-recovery (6%). Membership in Resilient-Stable and Resilient-Recovery trajectories was associated with fewer depressive symptoms (OR = 0.86, 95% CI 0.78, 0.94) and chronic conditions (OR = 0.21, 95% CI 0.06, 0.74), larger social networks (OR = 2.03, 95% CI 1.06, 3.86), more close friends and relatives (OR = 1.15, 95% CI 1.01, 1.32), and caring for someone other than a child (OR = 0.19, 95% CI 0.07, 0.51) compared to the Non-recovery group.

Conclusion

Becoming a family carer was associated with a decline in SWL over time in some carers. However, most carers either did not experience a decline in SWL or recovered their SWL over time. We found that both individual and community-level supports may be protective for carers' wellbeing. These results will inform the priorities for social and community-level services and support for older carers and contribute to the design of new projects and programs to meet these needs.
“Words are too small”: exploring artmaking as a tool to facilitate dialogues with young South African women about their sexual and reproductive health experiences
Authors: Hartley Felicity , Knight Lucia , Humphries Hilton , Trappler Jill , Gill Katherine , Bekker Linda-Gail , MacKenny Virginia , Passmore Jo-Ann S.
Published: August 2023

Background

Adolescents and young women are at high risk for sexually transmitted infections (STIs) and unintended pregnancies. However, conversations about sexual and reproductive health (S&RH) are difficult and stigmatised. Visual art-based approaches have been a useful adjunct to language-dependent interviews, encouraging embodied memory recall. Here, we explored a novel visual art-based methodology—“Stories from the Edge”—with a cohort of young women to understand how artmaking might facilitate dialogue of how S&RH experiences influenced behaviour, to enrich dialogues captured in the individual in-depth interviews (IDIs).

Methods

Seven isiXhosa-speaking young women (aged 21–25 years) were recruited into a six-session art-based engagement, painting the stories of their S&RH experiences. Large format artmaking and IDIs contributed to the data set. IDIs were audio recorded, transcribed, and translated and then analysed thematically.

Results

Young women felt that the visual art-based methodology eased barriers to communicating experiences of S&RH-seeking behaviours, with one woman commenting that “words are too small” to capture lived experiences. Artmaking provided the opportunity to express emotional complexities of the pleasures of intimate relationships and the heartbreak of betrayal for which they had no language. Significant social relationships (family, partners, peers) influenced sexual and reproduction attitudes and practices more than healthcare facilities and staff and more distal socio-cultural attitudes/practices. These influences shifted from adolescence to adulthood—from family to peer and partners.

Conclusion

Young women valued using the art-based methodology, which facilitated recall and verbalising their S&RH experiences more fully than language-only research. The process outlined here could provide a creative method that builds communication skills to negotiate the needs and desires of young women with partners and staff at S&RH services.
Libifem® (Trigonella foenum-graecum) in conjunction with exercise on muscle strength, power, endurance, and body composition in females aged between 25 and 45 years
Authors: Rao Amanda , Clayton Paul , Briskey David
Published: August 2023

Introduction

This study examined the effects of Libifem® on exercise performance and body composition in females 25–45 years old.

Methods

Participants were randomized to three equal groups to consume: 600 mg Libifem®/day, 300 mg Libifem®/day or a placebo for 8 weeks. Participants completed a whole-body exercise program three times a week for 8 weeks. At baseline, week 4 and week 8, muscle strength and endurance, functional threshold power, body composition, and sex hormones were measured. At week 8, all three groups increased leg press 1RM compared to baseline.

Results

A significant difference between group treatment effect was seen for leg press at week 8 (p = 0.045), with the 600 mg Libifem® group significantly increasing their leg press 1RM compared to placebo (p = 0.014). The 600 mg Libifem® group significantly reduced their total fat mass (0.96 kg loss) from baseline compared to placebo group (0.09 kg gain). There was no significant difference in fat mass for the 300 mg Libifem® group (0.23 kg loss). The 600 mg Libifem® group had a significant increase in lean mass compared to both the 300 mg and placebo groups (p = 0.011 and 0.009, respectively).

Discussion

Overall, there were significant and dose-related changes in body composition and ergogenic parameters, comparable with previous findings in males.

Clinical Trial Registration

This trial was registered with the Australian and New Zealand Clinical Trials registry [ACTRN12618001538235].
Neglected zoonotic helminthiases in wild canids: new insights from South America
Authors: Uribe Manuel , Brabec Jan , Chaparro-Gutiérrez Jenny J. , Hermosilla Carlos
Published: August 2023

The global threat of neglected tropical diseases (NTDs) constitutes a public health issue in underdeveloped countries. Zoonotic helminthiases are the most common human NTD agents in developing countries in sub-Saharan Africa, Asia, and the Americas, causing a global burden of disease that exceeds that of more recognized infectious diseases such as malaria and tuberculosis. Wild canids are well-known mammals that act as natural reservoirs of zoonotic-relevant helminthiasis worldwide, thus playing a pivotal role in their epidemiology and transmission to humans. Here we evaluate the occurrence of zoonotic gastrointestinal helminths in two Neotropical wild canid species from the Amazonian and Andean regions of Colombia, i.e., the bush dog (Speothos venaticus) and the crab-eating fox (Cerdocyon thous). We recovered tapeworm proglottids from bush dog fecal samples and identified them molecularly as the canine-specific lineage of Dipylidium caninum by using cytochrome c oxidase subunit I (cox1) gene sequences. Moreover, examination of a crab-eating fox during necropsy revealed the presence of non-embryonated eggs of the neglected nematode Lagochilascaris cf. minor, in addition to eggs and gravid proglottids of the cestode Spirometra mansoni. These findings represent the first report of zoonotic-relevant cestodes, i.e., D. caninum (“canine genotype”), S. mansoni, and the nematode L. cf. minor, in bush dogs and crab-eating foxes as final hosts. The occurrence of these zoonotic helminthiases in wild canid species calls for regular monitoring programs to better understand the epidemiology and transmission routes of neglected dipylidiasis, lagochilascariosis, and sparganosis in South America.
Flood Protection Partial Analysis of the Olt Bridge in Sântimbru
Authors: Kisfaludi-Bak Zsombor , Gobesz F.-Zsongor
Published: August 2023

In many places in Transylvania, we can observe the ruins and remains of buildings, from which many interesting conclusions can be drawn. As part of a more comprehensive research, in which the flood protection safety of old Transylvanian bridges is examined, in this case the rebuilt road bridge in Santimbru was investigated. Modelling and hydraulic calculations performed on the basis of in situ measurements can reveal the old hydraulic construction requirements used in the design of the bridge, and then the data were also considered in the light of today's standards.
Anomaly Detection with Artificial Intelligence Methods : An Overview
Authors: Sebestyén Pál György , Hangan Lia-Anca , Czakó Zoltán
Published: August 2023

Nowadays, more and more human activities depend on computer-based automated systems. Fully automated (robotized) production lines, energy distribution infrastructures and other urban services or environmental surveillance systems are just some examples of cyber-physical systems that depend entirely on automated control systems. In these cases a significant challenge is to identify abnormal behaviors of the supervised or controlled systems, in order to avoid malfunction or sometimes catastrophic events. Our main research goal was to evaluate the potential of adapting and using AI techniques in the field of anomaly detection. We also developed a platform, called AutomaticAI, which can help specialists in different domains to identify the best approaches to solve a given anomaly detection problem. The platform can select the best AI algorithm and parameter configuration for a given set of data containing normal and abnormal data. The tool was used successfully in a variety of domains, from cyber-physical systems to the medical domain.
Dim Staring Debris Targets Detection Method with Dense Long Trailing Star
Authors: Yu Jiyang , Huang Dan , Li Wenjie , Wang Xianjie , Shi Xiaolong
Published: August 2023

With the gradual increase in spacecraft in orbit, space debris monitoring has become the key to the sustainable development of space missions. A staring debris detection method is proposed for high-density stars with long tails. In order to solve the problem that the gray level of a long trailing image is not stable and continuous, rectangular fitting is used to complete the aggregation of the trailing image and reduce the influence of noise on the trailing information. The occluded state of the target was analyzed, the feature calculation method was improved, the semi-occluded scene was statistically classified, the fully connected network (FCN) based finite point feature was accurately classified, and the semi-occluded image was extracted. Based on the extracted semi-occluded image, the inter-frame association can improve the success probability of target association and realize the effective detection and tracking of debris. The detection accuracy was tested for the changing inter-frame interval and signal-to-noise ratio (SNR), and the relationship between the index parameters and key parameters was given. Compared with previous literature, this design can detect and track the occluded target with a detection rate of more than 90% and a false alarm rate of less than 10%.
Study on the Stress Performance of an Incompletely Prefabricated Profile Steel Reactive Powder Concrete Column in High-Rise Modular Buildings
Authors: Liao Wei , Yang Weijun , Yang Jianyu
Published: August 2023

In this study, 11 PSRPC column specimens were designed and fabricated in order to investigate the stressing performance of incompletely prefabricated steel reactive powder concrete (PSRPC) columns and were subjected to static loading tests. The effects of the strength grade and steel content of reactive powder concrete (RPC) on the axial compression performance of PSRPC columns and the effects of the steel content and eccentricity on the eccentricity performance of PSRPC columns were investigated. The test results show that the external prefabricated RPC, the internal steel section and the internal cast-in-place RPC of the PSRPC column work well together. The damage morphology of the specimens and the load–displacement and strain relationships were analysed, and the damage mechanism and the main factors influencing the compressive load capacity of the PSRPC columns were investigated. The test results are compared with the calculation results of the Chinese code (JGJ 138-2016) and the European and American codes (AISC-LRFD), and the applicability of the existing codes is discussed. Based on the hoop restraint action and limit state design method, formulae for calculating the axial and partial compression load capacity of PSRPC columns were established. The calculated values were in good agreement with the test values, and the calculation errors were within 10%.
In Patients Treated by Selective Internal Radiotherapy, Cellular In Vitro Immune Function Is Predictive of Survival
Authors: Domouchtsidou Aglaia , Beckmann Ferdinand , Marenbach Beate , Mueller Stefan P. , Best Jan , Herrmann Ken , Horn Peter A. , Barsegian Vahé , Lindemann Monika
Published: August 2023

In patients with liver malignancies, the cellular immune function was impaired in vitro after selective internal radiotherapy (SIRT). Because immunosuppression varied substantially, in the current study, we investigated in 25 SIRT patients followed up for ten years whether the lymphocyte function was correlated with survival. Peripheral blood mononuclear cells were stimulated with four microbial antigens (tuberculin, tetanus toxoid, Candida albicans and CMV) before therapy and at four time points thereafter, and lymphocyte proliferation was determined by H3-thymidine uptake. The median sum of the responses to these four antigens decreased from 39,464 counts per minute (CPM) increment (range 1080–204,512) before therapy to a minimum of 700 CPM increment on day 7 after therapy (0–93,187, p < 0.0001). At all five time points, the median survival in patients with weaker responses was 2- to 3.5-fold shorter (p < 0.05). On day 7, the median survival in patients with responses below and above the cutoff of a 2 CPM increment was 185 and 523 days, respectively (χ2 = 9.4, p = 0.002). In conclusion, lymphocyte function could be a new predictor of treatment outcome after SIRT.
CPSF3 Promotes Pre-mRNA Splicing and Prevents CircRNA Cyclization in Hepatocellular Carcinoma
Authors: Huang Ying , Ji Haofei , Dong Jiani , Wang Xueying , He Zhilin , Cheng Zeneng , Zhu Qubo
Published: August 2023

CircRNAs are crucial in tumorigenesis and metastasis, and are comprehensively downregulated in hepatocellular carcinoma (HCC). Previous studies demonstrated that the back-splicing of circRNAs was closely related to 3′-end splicing. As a core executor of 3′-end cleavage, we hypothesized that CPSF3 modulated circRNA circularization. Clinical data were analyzed to establish the prognostic correlations. Cytological experiments were performed to determine the role of CPSF3 in HCC. A fluorescent reporter was employed to explore the back-splicing mechanism. The circRNAs regulated by CPSF3 were screened by RNA-seq and validated by PCR, and changes in downstream pathways were explored by molecular experiments. Finally, the safety and efficacy of the CPSF3 inhibitor JTE-607 were verified both in vitro and in vivo. The results showed that CPSF3 was highly expressed in HCC cells, promoting their proliferation and migration, and that a high CPSF3 level was predictive of a poor prognosis. A mechanistic study revealed that CPSF3 enhanced RNA cleavage, thereby reducing circRNAs, and increasing linear mRNAs. Furthermore, inhibition of CPSF3 by JET-607 suppressed the proliferation of HCC cells. Our findings indicate that the increase of CPSF3 in HCC promotes the shift of pre-mRNA from circRNA to linear mRNA, leading to uncontrolled cell proliferation. JTE-607 exerted a therapeutic effect on HCC by blocking CPSF3.
A Review of Planned, Ongoing Clinical Studies and Recent Development of BNCT in Mainland of China
Authors: Zhang Zizhu , Chong Yizheng , Liu Yuanhao , Pan Jianji , Huang Cheng , Sun Qi , Liu Zhibo , Zhu Xiayang , Shao Yujun , Jin Congjun , Liu Tong
Published: August 2023

Boron neutron capture therapy (BNCT) is a promising cancer treatment modality that combines targeted boron agents and neutron irradiation to selectively destroy tumor cells. In mainland China, the clinical implementation of BNCT has made certain progress, primarily driven by the development of compact neutron source devices. The availability, ease of operation, and cost-effectiveness offered by these compact neutron sources make BNCT more accessible to cancer treatment centers. Two compact neutron sources, one being miniature reactor-based (IHNI-1) and the other one being accelerator-based (NeuPex), have entered the clinical research phase and are planned for medical device registration. Moreover, several accelerator-based neutron source devices employing different technical routes are currently under construction, further expanding the options for BNCT implementation. In addition, the development of compact neutron sources serves as an experimental platform for advancing the development of new boron agents. Several research teams are actively involved in the development of boron agents. Various types of third-generation boron agents have been tested and studied in vitro and in vivo. Compared to other radiotherapy therapies, BNCT in mainland China still faces specific challenges due to its limited clinical trial data and its technical support in a wide range of professional fields. To facilitate the widespread adoption of BNCT, it is crucial to establish relevant technical standards for neutron devices, boron agents, and treatment protocols.
A Luminex Approach to Develop an Anti-Tumor-Associated Antigen Autoantibody Panel for the Detection of Prostate Cancer in Racially/Ethnically Diverse Populations
Authors: Qiu Cuipeng , Wang Xiao , Batson Serina A. , Wang Bofei , Casiano Carlos A. , Francia Giulio , Zhang Jian-Ying
Published: August 2023

(1) Background: Autoantibodies to tumor-associated antigens (TAAs) have emerged as promising cancer biomarkers. Luminex technology offers a powerful approach for the simultaneous detection of multiple anti-TAA autoantibodies. (2) Methods: We aimed to utilize Luminex technology to evaluate and optimize a panel of anti-TAAs autoantibodies for detecting prostate cancer (PCa), which included autoantibodies to fourteen TAAs. A total of 163 serum samples (91 PCa, 72 normal controls) were screened to determine the levels of the autoantibodies using the Luminex assay. (3) Results: Twelve autoantibodies exhibited significantly high frequencies ranging from 19.8% to 51.6% in the PCa group. Receiver operating characteristic (ROC) curve analysis revealed area under the curve (AUC) values ranging from 0.609 to 0.868 for the twelve autoantibodies individually. We further confirmed the performance of the HSP60 autoantibody by using an enzyme-linked immunosorbent assay (ELISA) in a larger sample comprising 200 PCa sera, 20 benign prostatic hyperplasia (BPH) sera, and 137 normal control sera. The results obtained from the Luminex assay were consistent with the ELISA findings. We developed a panel consisting of three autoantibodies (p16, IMP2, and HSP60) which achieved an impressive AUC of 0.910 with a sensitivity of 71.4% and a specificity of 95.8%. The panel was also evaluated in PCa patients from different races/ethnicities with the best performance observed in distinguishing the Hispanic American patients with PCa from normal controls. (4) Conclusions: We developed an anti-TAA autoantibody panel for the detection of PCa that exhibits promising performance. This panel holds significant potential as a high-throughput tool to facilitate PCa detection.
Reduction of Blood Loss by Means of the Cavitron Ultrasonic Surgical Aspirator for Thoracoscopic Salvage Anatomic Lung Resections
Authors: Wang Yu-Hsiang , Tsai Stella Chin-Shaw , Lin Frank Cheau-Feng
Published: August 2023

In centrally located lung tumors, salvage pulmonary resections pose challenges due to adhesions between the pulmonary parenchyma, chest wall, and hilum. This study aimed to investigate the surgical outcomes associated with Cavitron Ultrasonic Surgical Aspirator (CUSA) usage in thoracoscopic salvage pulmonary resections. Patients with centrally located advanced-stage lung tumors who underwent salvage anatomic resections following systemic or radiotherapy were included. They were categorized into CUSA and non-CUSA groups, and perioperative parameters and surgical outcomes were analyzed. Results: The study included 7 patients in the CUSA group and 15 in the non-CUSA group. Despite a longer median surgical time in the CUSA group (3.8 h vs. 6.0 h, p = 0.021), there was a significant reduction in blood loss (100 mL vs. 250 mL, p = 0.014). Multivariate analyses revealed that the use of CUSA and radiotherapy had opposing effects on blood loss (β: −296.7, 95% CI: −24.8 to −568.6, p = 0.034 and β: 282.9, 95% CI: 19.7 to 546.3, p = 0.037, respectively). In conclusion, while using CUSA in the salvage anatomic resection of centrally located lung cancer may result in a longer surgical time, it is crucial in minimizing blood loss during the procedure.
The Transport and Optical Characteristics of a Metal Exposed to High-Density Energy Fluxes in Compressed and Expanded States of Matter
Authors: Volkov Nikolay B. , Lipchak Alexander I.
Published: August 2023

This article presents a theoretical study of the optical and transport properties of metals. Iron, as an example, was used to discuss, through a theoretical description, the peculiarities of these properties in the compressed and expanded states under the influence of high-density energy fluxes. By solving the semi-classical Boltzmann equation for conduction electrons for a broad range of densities and temperatures, the expressions of electrical conductivity, electronic thermal conductivity, and thermoelectric coefficient calculations were derived. The real and imaginary parts of the iron permittivity and the energy absorption coefficient for the first and second harmonics of Nd:YAG laser radiation were obtained. The calculation peculiarities of the metal’s optical characteristics of matter in an expanded state in a broad range of densities and temperatures were considered. The analysis of the obtained results shows their agreement with the theoretical description for cases of ideal non-degenerate and dense degenerate electron plasmas. It is shown that the behavior of the electrical conductivity and optical characteristics in the critical and supercritical regions of density and temperature are in agreement with the known experimental results.
Dehydration of Isopropanol: A Comparative Review of Distillation Processes, Heat Integration, and Intensification Techniques
Authors: Nhien Le Cao , Agarwal Neha , Lee Moonyong
Published: August 2023

The dehydration of isopropanol (IPA) is a crucial process in numerous industries, and the optimization of its efficiency and economic viability is essential. This review provides a comprehensive analysis and comparison of various distillation processes, heat integration (HI) strategies, and process intensification (PI) techniques employed for IPA dehydration. The advantages, limitations, and applicability of distillation processes, such as extractive distillation, heterogeneous azeotropic distillation, and pressure swing distillation, are discussed. In addition, this review explores the potential of HI techniques to optimize energy consumption and reduce operating costs of IPA dehydration processes. PI techniques, including thermally coupled arrangements and dividing wall columns, are examined for their ability to improve the process efficiency and sustainability. It is crucial to conduct thorough evaluations, as well as energy and economic analyses, when choosing the appropriate distillation process, HI approach, and PI technique for specific IPA dehydration applications. This review emphasizes the potential for improving the energy efficiency, product purity, and cost-effectiveness of IPA dehydration through the integration of advanced distillation processes and PI techniques.
Investment and Bidding Strategies for Optimal Transmission Management Dynamics: The Italian Case
Authors: Di Persio Luca , Fraccarolo Nicola
Published: August 2023

This paper explores the allocation process of Financial Transmission Rights (FTRs) in the Italian electricity market. FTRs are financial instruments allowing market participants to hedge against transmission congestion, also playing a critical role in ensuring the efficient use of the transmission system. We present a linear programming (LP) model that simulates the FTRs allocation process, taking into account the transmission capacity limits of the electric network when the total revenue is considered as the utility function. Obtained results highlight that our solution allows us to develop better investment and bidding strategies for optimal transmission management dynamics. In particular, numerical simulations show good results, with an overall MAPE of approximately 7%, indicating that the model accurately predicts the allocation of transmission rights across the network. Overall, the paper provides insights into the inner workings of the FTR allocation process in Italy, also providing improved market efficiency while increasing revenue for market participants.
Comparison between Mullite-Based and Anorthite-Based Porcelain Tiles: A Review
Authors: Li Kun , Cordeiro Eloise de Sousa , De Noni Agenor
Published: August 2023

This paper begins with an introduction to porcelain tiles. A review of the major scientific and technological features of mullite-based porcelain tiles (MPTs) and anorthite-based porcelain tiles (APTs), focusing primarily on the raw material, processing, phase evolution and mechanical behavior, is then presented. Based on the porcelain tile firing behavior and a series of physical and chemical changes that can occur, a comprehensive comparison is described. In the last part, the prospects for further developments related to MPTs and APTs are discussed.
Real-World Utilization of Molnupiravir during the COVID-19 Omicron Surge in Israel
Authors: Weil Clara , Bergroth Tobias , Eisenberg Anna , Whiteside Yohance Omar , Caraco Yoseph , Tene Lilac , Chodick Gabriel
Published: August 2023

Molnupiravir (MOV) was introduced in Israel in January 2022 during the SARS-CoV-2 Omicron surge for high-risk patients contraindicated for nirmatrelvir/ritonavir. This retrospective cohort study aimed to describe characteristics of patients offered COVID-19 antiviral treatment in Maccabi Healthcare Services (antiviral treatment-eligible cohort; n = 5596) between 12 January and 28 February 2022, and the subset of these who were dispensed MOV (MOV-treated cohort; n = 1147), as well as outcomes following MOV dispensation. Median (interquartile range) age in the antiviral treatment-eligible and MOV-treated cohorts were 70.5 (61.1, 77.3) and 74.1 (64.3, 81.7) years, respectively. The MOV-treated cohort (male: 53.2%) had high rates of COVID-19 vaccination (91.4%) and comorbidities, including immunosuppression (40.0%) and chronic kidney disease (67.0%; eGFR < 30 mL/min/1.73 m2: 28.8%), and most used comedications either contraindicated or with major potential for drug–drug interactions with nirmatrelvir/ritonavir (87.3%). At 28 days post-MOV dispensation, the cumulative incidence (95% CI) of COVID-19-related hospitalization and/or all-cause mortality was 3.6% (2.5%, 4.6%), with similar rates across sexes and age groups (18–64 vs. ≥65 years), and lower rates among recently vaccinated and/or recently SARS-CoV-2-infected patients. These data describe the characteristics and outcomes for MOV-treated patients in Israel, whose clinical characteristics may preclude the use of nirmatrelvir/ritonavir to treat their COVID-19 infection.
Potential Carbon Sequestration and Economic Value Assessment of the Relict Plant Ginkgo biloba L. Based on the Maximum Entropy Model
Authors: Zhang Xiaoting , He Ping , Guo Longfei , Meng Fanyun
Published: August 2023

As global warming intensifies, plant carbon sequestration is becoming increasingly important. Studies have shown that Ginkgo biloba L. is a kind of tree with a high carbon sequestration capacity and is one of the dominant tree species suitable for urban ecosystems. Predicting the changes in the potential suitable areas, carbon sequestration amount and carbon sink value of G. biloba under current and future climate change will provide some references for the resource utilization of urban green tree species and the realization of carbon sink value. In this study, we used ‘kuenm’, an R package that uses MaxEnt, as a modeling algorithm to predict the potential suitable areas of G. biloba under nine climate scenarios, and the carbon sequestration and the carbon sink values under the fair-value measurement model were calculated. We found that: (1) the optimized MaxEnt model improved the prediction accuracy (AUC = 0.97 ± 0.004) significantly. (2) The total current potential suitable area of G. biloba was 175.11 × 104-km2, representing 21.63% of China’s total territorial area, and the highly suitable area was 26.86 × 104-km2, accounting for 2.83% of China’s total territorial area, concentrated primarily in the regions of Sichuan and Chongqing, southern Jiangsu, and Zhejiang Province. (3) The eight future climate scenarios predict that the suitable area of G. biloba will initially decrease and then increase, and the newly expanded area will be distributed primarily in the middle and upper reaches of the Yangtze River as well as near the estuary of the Yangtze River, while the region suffering losses will move from Sichuan and Chongqing to Hunan, Jiangxi and Zhejiang Province as well. Hf and bio2 are the major factors affecting the distribution of G. biloba. (4) The total annual carbon sequestration of G. biloba was 1.60 × 106-t, 1.50 × 106-t and 1.57 × 106-t under different environmental conditions in the present, the 2050s and the 2090s, respectively. Over these three time periods, we obtained total carbon sequestration values of 5.63 × 107 CNY, 5.28 × 107 CNY and 5.53 × 107 CNY.
An Efficient Approach to Solving the Fractional SIR Epidemic Model with the Atangana–Baleanu–Caputo Fractional Operator
Authors: Riabi Lakhdar , Hamdi Cherif Mountassir , Cattani Carlo
Published: August 2023

In this article, we study the fractional SIR epidemic model with the Atangana–Baleanu–Caputo fractional operator. We explore the properties and applicability of the ZZ transformation on the Atangana–Baleanu–Caputo fractional operator as the ZZ transform of the Atangana–Baleanu–Caputo fractional derivative. This study is an application of two power methods. We obtain a special solution with the homotopy perturbation method (HPM) combined with the ZZ transformation scheme; then we present the problem and study the existence of the solution, and also we apply this new method to solving the fractional SIR epidemic with the ABC operator. The solutions show up as infinite series. The behavior of the numerical solutions of this model, represented by series of the evolution in the time fractional epidemic, is compared with the Adomian decomposition method and the Laplace–Adomian decomposition method. The results showed an increase in the number of immunized persons compared to the results obtained via those two methods.
Molecular and Cellular Advances in Endometriosis Research: Paving the Way for Future Directions
Authors: Laganà Antonio Simone , Ferrari Federico , Mangione Donatella , Fiorino Fabio , Vassiliadis Alessandra , Venezia Renato
Published: August 2023

Molecular and cellular research in the field of endometriosis is moving forward in giant steps [...]
A Novel Role of Medicago truncatula KNAT3/4/5-like Class 2 KNOX Transcription Factors in Drought Stress Tolerance
Authors: Iannelli Maria Adelaide , Nicolodi Chiara , Coraggio Immacolata , Fabriani Marco , Baldoni Elena , Frugis Giovanna
Published: August 2023

Class 2 KNOX homeobox transcription factors (KNOX2) play a role in promoting cell differentiation in several plant developmental processes. In Arabidopsis, they antagonize the meristematic KNOX1 function during leaf development through the modulation of phytohormones. In Medicago truncatula, three KNOX2 genes belonging to the KNAT3/4/5-like subclass (Mt KNAT3/4/5-like or MtKNOX3-like) redundantly works upstream of a cytokinin-signaling module to control the symbiotic root nodule formation. Their possible role in the response to abiotic stress is as-of-yet unknown. We produced transgenic M. truncatula lines, in which the expression of four MtKNOX3-like genes was knocked down by RNA interference. When tested for response to water withdrawal in the soil, RNAi lines displayed a lower tolerance to drought conditions compared to the control lines, measured as increased leaf water loss, accelerated leaf wilting time, and faster chlorophyll loss. Reanalysis of a transcriptomic M. truncatula drought stress experiment via cluster analysis and gene co-expression networks pointed to a possible role of MtKNOX3-like transcription factors in repressing a proline dehydrogenase gene (MtPDH), specifically at 4 days after water withdrawal. Proline measurement and gene expression analysis of transgenic RNAi plants compared to the controls confirmed the role of KNOX3-like genes in inhibiting proline degradation through the regulation of the MtPDH gene.
Progressive Thinning of Retinal Nerve Fiber Layer/Ganglion Cell Layer (RNFL/GCL) as Biomarker and Pharmacological Target of Diabetic Retinopathy
Authors: Zerbini Gianpaolo , Maestroni Silvia , Viganò Ilaria , Mosca Andrea , Paleari Renata , Gabellini Daniela , Galbiati Silvia , Rama Paolo
Published: August 2023

Diabetes-driven retinal neurodegeneration has recently been shown to be involved in the initial phases of diabetic retinopathy, raising the possibility of setting up a preventive strategy based on early retinal neuroprotection. To make this possible, it is crucial to identify a biomarker for early retinal neurodegeneration. To this end, in this study, we verified and confirmed that, in the Akita mouse model of diabetes, the thinning of the retinal nerve fiber layer/ganglion cell layer (the RNFL/GCL—the layer that contains the retinal ganglion cells) precedes the death of these same cells, suggesting that this dysfunction is a possible biomarker of retinal neurodegeneration. We then confirmed the validity of this assumption by starting a neuroprotective treatment (based on nerve growth factor eye drops) in concert with the first demonstration of RNFL/GCL thinning. In this way, it was possible not only to avoid the loss of retinal ganglion cells but also to prevent the subsequent development of the microvascular stage of diabetic retinopathy. In conclusion, in the case of diabetes, the thinning of the RNFL/GCL appears to be both a valid biomarker and a pharmacological target of diabetic retinopathy; it precedes the development of vascular dysfunctions and represents the ideal starting point for prevention.
Transplant Immunobiology: Many Answers Raising Even More Questions
Authors: Oltean Mihai
Published: August 2023

Immunologic complications following organ, cell, or tissue transplantation still raise significant challenges related to their diagnosis and treatment [...]
Conditional Loss of MEF2C Expression in Osteoclasts Leads to a Sex-Specific Osteopenic Phenotype
Authors: Maisuria Ravi , Norton Andrew , Shao Cynthia , Bradley Elizabeth W. , Mansky Kim
Published: August 2023

Myocyte enhancement factor 2C (MEF2C) is a transcription factor studied in the development of skeletal and smooth muscles. Bone resorption studies have exhibited that the reduced expression of MEF2C contributes to osteopetrosis and the dysregulation of pathological bone remodeling. Our current study aims to determine how MEF2C contributes to osteoclast differentiation and to analyze the skeletal phenotype of Mef2c-cKO mice (Cfms-cre; Mef2cfl/fl). qRT-PCR and Western blot demonstrated that Mef2c expression is highest during the early days of osteoclast differentiation. Osteoclast genes, including c-Fos, c-Jun, Dc-stamp, Cathepsin K, and Nfatc1, had a significant reduction in expression, along with a reduction in osteoclast size. Despite reduced CTX activity, female Mef2c cKO mice were osteopenic, with decreased bone formation as determined via a P1NP ELISA, and a reduced number of osteoblasts. There was no difference between male WT and Mef2c-cKO mice. Our results suggest that Mef2c is critical for osteoclastogenesis, and that its dysregulation leads to a sex-specific osteopenic phenotype.