bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimization of the biological salt removal process from artificial industrial wastewater with high TDS by Spirulina microalga using the response surface method
Authors: Ghalhari Maryam Asadi , Mafigholami Roya , Takdastan Afshin , Khoshmaneshzadeh Behnoosh
Published: August 2022

This study aimed to examine the direct applicability of Spirulina maxima as a new conceptual method for removing total dissolved solids (TDS) from artificial industrial wastewater (AIW). In this study, live microalgal cells were used in a photobioreactor for TDS removal. The effects of TDS levels, pH, light intensity, and light retention time on microalgal growth and TDS removal were investigated, and optimal conditions were determined using the response surface method and Box-Behnken Design (RSM-BBD). The calculated values of coefficient of determination (R2), adjusted R2, and predicted R2 were 0.9754, 0.9508, and 0.636, respectively, which are close to the R2 values and validated the proposed statistical model. A second-order model could optimally determine the interactions between the studied variables according to the one-way analysis of variance (ANOVA). The results showed that increasing TDS levels reduced microalgal growth and TDS removal efficiency in AIW. S. maxima reduced TDS by 76% and 47% at TDS concentrations of 2,000–4,000 mg/L, respectively, when used in AIW. Maximum biomass efficiency (1.8 g/L) was obtained at a TDS concentration of 2,000 mg/L with other parameters optimized.
Bioactive Compounds in Rheumatoid Arthritis
Authors: Vengurlekar Sudha , Chandra Chaturvedi Subhash
Published: August 2022

Rheumatoid arthritis is a severe systemic autoimmune disorder with limited
option available for treatment and no curative therapy available at present. Rheumatoid
arthritis manifests clinically through polyarthralgia related to joint dysfunction, which
triggers the autoimmune responses associated with antibodies against the self.neoepitopes and causes the chronic arthritic attack. Bone destruction is an important
feature to understand the pathology of rheumatoid arthritis, which may lead to a serious
concern for the patient for living a quality life. Available drugs for rheumatoid arthritis
such as methotrexate, hydroxychloroquine, and sulfasalazine exert effects on bone
metabolism in immune cells and cytokines that result in relieving pain, improving the
quality of life but still, the chronic teratogenic and toxic effects are challenging in
management of anti-arthritic drugs. This chapter reviews the current trend of bioactive
compounds for the treatment of rheumatoid arthritis, which may lead to the
development of novel anti-rheumatoid arthritis agents.
Herbal Formulations Useful in the Treatment of Rheumatoid Arthritis
Authors: M. Baheti Akshay , T. Pawar Anil
Published: August 2022

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease of
joints. About 1% of the world's adult population is affected by RA. The commonly
used medications for RA are anti-inflammatory and disease-modifying agents. These
drugs revise the pathology and restore the quality of life but fail to completely cure the
disease. Furthermore, they cause various side effects such as gastrointestinal disorders,
cardiovascular toxicity, immunodeficiency, and irreversible organ damage. This has led
to greater global interest in herbal medicines due to better tolerance and minimum side
effects than synthetic drugs. These herbs are used in traditional forms like vatika,
gutika, medicated oils, medicated ghee, or in different modern formulations such as
tablets, capsules, gels and ointments. A large segment of RA patients has started
adopting herbal formulations and traditional systems of medicines; there is a need to
compile the data on herbal formulations used in RA management. This chapter will
attempt to review herbal formulations of various systems of medicines used for
rheumatoid arthritis.
Pengaruh Pemberian Ekstrak Etanol Biji Pepaya (Carica papaya L.) terhadap Jumlah Folikel Preantral, Antral dan Berat Ovarium Tikus Putih Betina (Rattus norvegicus) Galur Wistar
Authors:   Midwifery Bachelor Program, Faculty of Medicine, Universitas Brawijaya, Ayuningtyas Diah , Anita Kenty Wantri ,   Department of Pathology Anatomy, Faculty of Medicine, Universitas Brawijaya, Irwanto Yahya ,   Department of Midwifery, Faculty of Medicine, Universitas Brawijaya
Published: August 2022

Biji Pepaya (Carica papaya L.) merupakan salah satu bagian tanaman pepaya yang digunakan sebagai obat tradisional. Bahan aktif yang terdapat pada biji pepaya ini dapat mempengaruhi hormon yang dibutuhkan dalam perkembangan folikel ovarium sehingga berpengaruh pada berat ovarium. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak etanol biji terhadap jumlah folikel dan berat ovarium tikus putih betina galur wistar. Studi eksperimental menggunakan randomised post test only control group design dilakukan terhadap hewan coba tikus putih betina (Rattus norvegicus) galur Wistar. Pembagian kelompok meliputi kontrol (K) (0 mg/g BB), perlakuan 1 (P1) (0,1 mg/g BB), perlakuan 2 (P2) (0,2 mg/g BB), dan perlakuan 3 (P3) (0,3 mg/g BB). Parameter dalam penelitian ini meliputi jumlah folikel (folikel preantral dan antral) dan berat ovarium. Hasil penelitian menunjukkan bahwa kenaikan jumlah dosis ekstrak etanol biji pepaya yang diberikan tidak berbeda secara signifikan pada penurunan jumlah folikel preantral (p-value=0,974), namun berpengaruh secara signifikan pada penurunan jumlah folikel antral (p-value=0,044). Terbukti adanya perbedaan rerata berat ovarium yang signifikan pada kenaikan dosis ekstrak etanol biji pepaya yang diberikan kepada tikus putih betina (p-value=0,003). Hasil uji korelasi Rank Spearman yang bermakna hanya ditunjukkan dari hubungan dosis perlakuan dan jumlah folikel antral (p-value=0,016). Kesimpulan: pemberian ekstrak etanol biji pepaya terbukti dapat mempengaruhi penurunan jumlah folikel antral, namun tidak terbukti menurunkan jumlah folikel preantral dan berat ovarium tikus putih betina galur wistar. Dosis ekstrak etanol biji pepaya yang memiliki pengaruh paling besar terhadap jumlah folikel antral tikus putih betina pada dosis 0,3 mg/g BB.
Kebutuhan Khusus pada Permasalahan Psikologi Perempuan pada Kehamilan tidak Diinginkan dengan Hipnoterapi
Authors:   Universitas Borneo Tarakan, Yulianti Ika , Citra Nur ,   Universitas Borneo Tarakan
Published: August 2022

Unwanted pregnancy status can have an impact on the psychological Â aspects of pregnancy. Hypnotherapy is one of the special needs that need to be given to overcome psychological problems in unwanted pregnancies. This research has not been done much in Indonesia. The purpose of the study was to find out the effect of hypnotherapy on women's psychological problems in unwanted pregnancies. Methods of using systematic review. Research from as many as 454 articles later analyzed PRISMA into 9 articles came from databases such as Pubmed, Science Direct, google scholar. The results showed that the pooled odds ratio obtained by 0.07 (95% CI 0.04 â€“ 0.15) so that it can be concluded that hypnotherapy can reduce the risk of 0.07 mothers to experience psychological problems and unwanted pregnancies are greater. There is a significant relationship between hypnotherapy and the incidence of psychological problems in pregnant women that are not desirable evidenced by p < 0.05 which is p = 0.00001
FAMILIA BALANOPHORACEAE
Authors:   Instituto de Ecología, A. C., Centro Regional del Bajío, Hernández-Ledesma Patricia
Published: August 2022

Familia de 16 géneros y alrededor de 43 especies distribuidas en regiones tropicales y subtropicales de ambos hemisferios, en el neotrópico se registran siete géneros y ca. 15 especies. En el área de estudio se registra Helosis.
FAMILIA OPHIOGLOSSACEAE
Authors:   Universidad Autónoma Metropolitana-Iztapalapa, Pacheco Leticia , Sánchez Morales Andrés ,   Universidad Autónoma Metropolitana-Iztapalapa, Guzmán Cornejo Laura ,   Universidad Autónoma Metropolitana-Iztapalapa
Published: August 2022

Familia con aproximadamente 112 especies distribuidas en 10 géneros: Helminthostachys, Mankyua, Cheiroglossa, Ophioderma, Ophioglossum, Rhizoglossum, Botrychium, Botrypus, Japanobotrychium y Sceptridium. Se distribuyen principalmente en zonas templadas, boreales, aunque algunas especies son pantropicales. Las plantas son en su mayoría terrestres y se conocen pocas epífitas. Para la región de estudio se registran tres géneros: Botrypus con una especie, Ophioglossum con tres y Sceptridium con dos.
FAMILIA NOLINACEAE
Authors:   Universidad Autónoma de Querétaro, Hernández-Sandoval Luis
Published: August 2022

A diferencia de lo que se propone en APG IV (Stevens, 2017), en este trabajo se considera la familia Nolinaceae en sentido estricto, en espera de mayor clarificación futura, en cuanto a nomenclatura y con relación a sus grupos asociados. La familia s.s. comprende cuatro géneros restringidos en su distribución a Norteamérica, con cerca de 65 especies, de las cuales casi 85% está en México. En este trabajo los cuatro géneros, Beaucarnea, Calibanus, Dasylirion y Nolina, están presentes en la región del Bajío y áreas adyacentes con 13 especies. Del total, Beaucarnea tiene registrada una, Calibanus dos, Dasylirion seis y Nolina cuatro. La mayoría de las especies en la familia tiene usos como plantas ornamentales y en ocasiones las hojas se utilizan para techar casas o hacer artesanías que pueden tener usos ceremoniales.
FAMILIA GRAMINEAE: SUBFAMILIA POÖIDEAE
Authors:   Instituto de Biología, Universidad Nacional Autónoma de México, Vigosa-Mercado J. Luis , Ruíz-Sánchez Eduardo ,   Herbario Luz María Villareal de Puga (IBUG), Centro Universitario de Ciencias Biológicas y Agropecuarias, Universidad de Guadalajara
Published: August 2022

La subfamilia Poöideae es la más diversa a nivel mundial entre las gramíneas, con ca. 202 géneros y 3968 especies (Soreng et al., 2017), aunque no es la mejor representada en México, donde se registran al menos 60 géneros y 260-292 especies (Dávila et al. 2018; Sánchez-Ken 2018). En la región de estudio se registran 29 géneros y 78 especies. Además de los taxones descritos más adelante, también se han reportado en la zona a los géneros Avenella Bluff ex Drejer, Melica L., Secale L. y Stipa L., sin embargo, su registro se hizo con base en identificaciones erróneas, o bien, no se encontró material de herbario que respalde su presencia. Los integrantes de esta subfamilia están distribuidos principalmente en regiones templadas y frías del mundo, también en los trópicos en grandes elevaciones, algunas son cosmopolitas y otras se desarrollan en regiones áridas. En este grupo se incluyen plantas de gran importancia económica como la avena (Avena sativa L.), la cebada (Hordeum vulgare L.), el centeno (Secale cereale L.) y el trigo (Triticum aestivum L.).
Web-Based Educational Intervention to Improve Knowledge of Systematic Reviews Among Health Science Professionals: Randomized Controlled Trial
Authors: Krnic Martinic Marina , Čivljak Marta , Marušić Ana , Sapunar Damir , Poklepović Peričić Tina , Buljan Ivan , Tokalić Ružica , Mališa Snježana , Neuberg Marijana , Ivanišević Kata , Aranza Diana , Skitarelić Nataša , Zoranić Sanja , Mikšić Štefica , Čavić Dalibor , Puljak Livia
Published: August 2022

Background

Lack of knowledge of systematic reviews (SRs) could prevent individual health care professionals from using SRs as a source of information in their clinical practice or discourage them from participating in such research.

Objective

In this randomized controlled trial, we evaluated the effect of a short web-based educational intervention on short-term knowledge of SRs.

Methods

Eligible participants were 871 Master’s students of university health sciences studies in Croatia; 589 (67.6%) students who agreed to participate in the trial were randomized using a computer program into 2 groups. Intervention group A (294/589, 49.9%) received a short web-based educational intervention about SR methodology, and intervention group B (295/589, 50.1%) was presented with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) checklist. The participants’ knowledge of SRs was assessed before and after the intervention. The participants could not be blinded because of the nature of the intervention. The primary outcome was the difference in the percentage of correct answers about SR methodology per participant between the groups after the intervention, expressed as relative risk and 95% CI.

Results

Results from 162 and 165 participants in the educational intervention and PRISMA checklist groups, respectively, were available for analysis. Most of them (educational intervention group: 130/162, 80.2%; PRISMA checklist group: 131/165, 79.4%) were employed as health care professionals in addition to being health sciences students. After the intervention, the educational intervention group had 23% (relative risk percentage) more correct answers in the postintervention questionnaire than the PRISMA checklist group (relative risk=1.23, 95% CI 1.17-1.29).

Conclusions

A short web-based educational intervention about SRs is an effective tool for short-term improvement of knowledge of SRs among health care studies students, most of whom were also employed as health care professionals. Further studies are needed to explore the long-term effects of the tested education.

Trial Registration

OSF Registries 10.17605/OSF.IO/RYMVC; https://osf.io/rymvc
Creating and Implementing a Principal Investigator Tool Kit for Enhancing Accrual to Late Phase Clinical Trials: Development and Usability Study
Authors: Higgins Kristin A , Thomas Alexandra , Soto Nancy , Paulus Rebecca , George Thomas J , Julian Thomas B , Hartson Stine Sharon , Markham Merry Jennifer , Werner-Wasik Maria
Published: August 2022

Background

Accrual to oncology clinical trials remains a challenge, particularly during the COVID-19 pandemic. For late phase clinical trials funded by the National Cancer Institute, the development of these research protocols is a resource-intensive process; however, mechanisms to optimize patient accrual after trial activation are underdeveloped across the National Clinical Trial Network (NCTN). Low patient accrual can lead to the premature closure of clinical trials and can ultimately delay the availability of new, potentially life-saving therapies in oncology.

Objective

The purpose of this study is to formally create an easily implemented tool kit of resources for investigators of oncology clinical trials within the NCTN, specifically the NRG Oncology cooperative group, in order to optimize patient accrual.

Methods

NRG Oncology sought to formally develop a tool kit of resources to use at specific time points during the lifetime of NRG Oncology clinical trials. The tools are clearly described and involve the facilitation of engagement of the study principal investigator with the scientific and patient advocate community during the planning, activation, and accrual periods. Social media tools are also leveraged to enhance such engagement. The principal investigator (PI) tool kit was created in 2019 and thereafter piloted with the NRG Oncology/Alliance NRG-LU005 phase II or III trial in small-cell lung cancer. The PI tool kit was developed by the NRG Oncology Protocol Operations Management committee and was tested with the NRG/Alliance LU005 randomized trial within the NCTN.

Results

NRG Oncology/Alliance NRG-LU005 has seen robust enrollment, currently 127% of the projected accrual. Importantly, many of the tool kit elements are already being used in ongoing NRG Oncology trials, with 56% of active NRG trials using at least one element of the PI tool kit and all in-development trials offered the resource. This underscores the feasibility and potential benefits of deploying the PI tool kit across all NRG Oncology trials moving forward.

Conclusions

While clinical trial accrual can be challenging, the PI tool kit has been shown to augment accrual in a low-cost and easily implementable fashion. It could be widely and consistently deployed across the NCTN to improve accrual in oncology clinical trials.

Trial Registration

ClinicalTrials.gov NCT03811002; https://clinicaltrials.gov/ct2/show/NCT03811002
Work Evaluation of the Construction Supervisory Consultants in Denpasar City
Authors: Damayanti Tirtha , Dharmayanti G.A.P Candra , Astana I Nyoman Yudha
Published: August 2022

The purpose of the study is to analyse the work of the supervisory consultant based on the criteria of the Indonesian National Work Competency Standards and to formulate efforts to improve the work of the supervisory consultant using AHP method and gap analysis. The result shows that on the government projects, the work of the supervising consultants in Denpasar City, especially on the criteria of the ability for controlling quality, design dimension, cost, and time; supervising the implementation of the work methods; evaluating and reporting the contractor works; and understanding the contract documents are in “good” category. Meanwhile, the result indicates that on private projects, the work of supervisory consultants, in terms of the ability to control quality, cost, time and design dimensions are in the "very good” category; the ability to supervise the application of work methods is in “good” category. In the government project, the client prioritizes the ability of the supervisory consultants in terms of ability to control quality, dimensions, cost, and time, to understand the contract documents, supervise the work methods, and evaluate and report the contractor's performance. Whereas in private projects, the client prioritizes the capabilities of the supervisory consultants in terms of the ability to control the project quality, design dimensions, cost, and time, to evaluate and report the contractor's performance.
Razonamiento probatorio sobre la admisibilidad de la prueba pericial en responsabilidad médica
Authors: Calahorrano Latorre Edison Ramiro
Published: August 2022

The role of expert evidence in medical liability and the criteria that should be taken into account for its admissibility in a free proof and rational assessment are analyzed. To ensure the expert evidence contributes to the clarification of the facts, its role in the Chilean doctrine and jurisprudence is studied, with application to medical liability, especially, the incidence of the expert opinion in the verification of fault and causation; later identification of the expert evidence with a testimonial character is verified; to immediately analyze the admissibility criteria of the expert evidence, the evidentiary reasoning to each one and the role of the burden of proof, all within the scope of the physician's civil liability; finally, the need to carry out exhaustive scrutiny on the epistemic quality of the admissible expert evidence is explained, establishing the content of the right to evidence as a limit for exclusion.
Cuentos, fábulas y cápsulas científicas. Versión bilingüe español-tseltal de Bachajón
Authors:   CIMSUR-UNAM, Schumann Gálvez Otto , Pérez Silvano César , Gutiérrez Miranda Felipe de Jesús
Published: August 2022

La existencia en Chiapas de más de doce lenguas indígenas y sus diferentes variantes dialectales nos recuerdan el carácter multicultural de México. Sin embargo, dado que la educación gubernamental en áreas indígenas se enmarca en la lengua española, poco se ha hecho para revertir el proceso de pérdida de lenguas originarias. Otto Schumann Gálvez se empeñó a lo largo de toda su vida en el estudio y desarrollo de las lenguas indígenas. Siempre destacó la necesidad de contar con textos de lectura en dichas lenguas y murió dirigiendo la traducción de los materiales publicados en este volumen a la lengua tseltal, la más hablada en Chiapas.
Clamar en el verde desierto. Mujeres en la historia contemporánea del sureste de México
Authors: Lisbona Guillén Miguel , De los Santos Chandomí Patricia , Carrillo Rodríguez Virginia C. , Negroe Sierra Genny , Fernández Repetto Francisco , Martín Díaz Josefa Guadalupe , Rosado Rosado Georgina , Canto Alcocer Alicia , Castro Gamboa Rita Concepción , Cortés Ancona Jorge , López Oliva María de los Milagros , Somosa Ibarra Karla Lizbeth , Villagómez Valdés Gina
Published: August 2022

Este libro realza el aporte de las mujeres en los siglos XIX y XX, siglo este último donde surgió el movimiento feminista en México. Desde diversas actividades, algunas vedadas para ser ejercidas por las mujeres, como el periodismo, la religión y la educación, o mediante el ejercicio de la prostitución o la celebración de congresos nacionales, las mujeres configuraron nuevas formas de ser que las constituirían años después en sujetos de pleno derecho en relación a sus grandes demandas: participación e igualdad política, educación, empleo o salud.
Akıllı Telefonlarda Bulunan Postür Düzeltme Uygulamalarının Boyun Ağrısı ve Fonksiyonuna Etkileri
Authors: BARĞI Gülşah , GÜNGÖRER Kubilay
Published: August 2022

Giriş: Akıllı telefonlar hayat kolaylaştıran birçok özelliklere sahip olduklarından hayatımızın her alanına hızla yerleşmiştir. Uzun süreli kullanımları sonucunda da bireylerde akıllı telefon bağımlılığı ile ilişkili olabilen kas-iskelet problemlerine neden olmuşlardır. Günümüzde öğretmenlerde mesleki maruziyet, COVID-19 pandemi süreci veya akıllı telefon bağımlılığına bağlı olarak kas iskelet problemleri görülebilmektedir. Ancak akıllı telefonlarda bulunan postür düzeltme uygulamalarının öğretmenlerin boyun ağrısı ve boyun fonksiyonlarına olan etkileri henüz bilinmemektedir. Bu sebeple bu çalışmada akıllı telefonlarda bulunan postür düzeltme uygulamalarının öğretmenlerin boyun ağrısı ve boyun fonksiyonlarına etkilerinin araştırılması amaçlandı.Yöntem: Prospektif randomize kontrollü olarak planlanan bu çalışmada öğretmenler rasgele uygulama (n=16, 34,75±5,08 yıl, postür düzeltme uygulaması kullanımı) ve kontrol (n=15, 35,20±4,57 yıl, sadece izleme) gruplarına ayrıldılar. Dört haftalık takip öncesi ve sonrasında tüm öğretmenlerde ağrı algılaması (Sayısal Ağrı Derecelendirme Ölçeği), boyun ağrısına bağlı özürlülük durumu (Boyun Özürlülük İndeksi) ve akıllı telefon bağımlılığı (Akıllı Telefon Bağımlılığı Ölçeği Kısa Formu) değerlendirildi.Sonuç: Öğretmenlerin başlangıç özellikleri gruplar arasında istatistik olarak benzerdi (p>0,05). Gruplar arasında dört haftalık takip öncesine göre uygulama sonrası değişim fark değerleri ve ağrı varlığı, boyun ağrısına bağlı özür durumları ve akıllı telefon bağımlılığı oranlarındaki değişim istatistik olarak benzerdi (p>0,05). Tartışma: COVID-19 pandemi sürecinde aktif olarak çalışan ve en az iki yıldır akıllı telefon kullanan öğretmenlerde boyun ağrısı (%56,3-%73,3), boyun ağrısına bağlı olarak hafif özür (%50-%53,3) ve akıllı telefon bağımlılığı (%12,5-%33,3) vardı. Dört hafta boyunca uygulamaları kullanan öğretmenlerde boyun ağrısı şiddeti, boyun ağrısına bağlı özür durumu ve akıllı telefon bağımlılığı değişmemektedir. Bu sebeple, öğretmenlerde boyun ağrısı ve fonksiyonlarını iyileştirmek için birebir gözetimli rehabilitasyon yaklaşımları düşünülmelidir.
Strategi Pengembangan Wisata Menara Kudus Berbasis Kearifan Lokal sebagai Upaya Pemulihan Ekonomi Masyarakat
Authors: Praatmana Nanang Dwi , Muhammad Arsyad
Published: August 2022

The existence of tourist objects as one of the pillars of the community's economy during the pandemic is decreasing. Along with the increasing number of Covid cases in Indonesia, several tourist attractions were closed due to the PPKM. The research aims to formulate alternative strategies that can be implemented in the development of the Menara Kudus tourist attraction during the pandemic. This is descriptive research with primary data sources consisting of observations and questionnaires. Technical sampling was chosen non probability sampling, because Menara Kudus is one of the popular tourist attractions in Kudus and offers a tourism concept that combines religion and culture. The analytical method used is SWOT. The results show that the position of the Menara Kudus tourist attraction is in quadrant I, meaning that the Menara Kudus tourist attraction is in strong internal and external conditions. An alternative strategy that can be applied is to highlight local wisdom in the form of cultural celebrations whose implementation is carried out by implementing health protocols as the main tourist attraction, with the hope that the community's economy can bounce back after going through the pandemic.
MENGANTISIPASI KESALAHAN PRODUKSI UJARAN UNTUK MENINGKATKAN KEMAMPUAN PUBLIC SPEAKING
Authors: Aisy Nabilah Rihadatul
Published: August 2022

Penelitian ini bertujuan untuk memahami lebih dalam kesalahan produksi ujaran yang meliputi senyapan dan kilir lidah, penyebab terjadinya, cara mengantisipasinya, dan bagaimana hal itu berpengaruh untuk meningkatkan public speaking. Kesalahan produksi ujaran adalah kekeliruan yang terjadi dalam proses menghasilkan suatu ujaran, yang membuat ujaran yang dihasilkan tidak sesuai dengan yang diinginkan. Penelitian ini menggunakan pendekatan kualitatif dengan metode analisis deskriptif. Teknik pengumpulan data dilakukan dengan metode dokumentasi dan simak-catat, yang selanjutnya dianalisis menggunakan teori kesalahan produksi ujaran yang meliputi senyapan dan kilir lidah dalam ilmu psikolinguistik. Hasil penelitian menunjukkan bahwa mengantisipasi kesalahan produksi ujaran, yaitu senyapan dan kilir lidah dapat dilalukan dengan mengatasi penyebab terjadinya kesalahan produksi ujaran; senyapan dan kilir lidah, yaitu grogi, tergesa-gesa, tidak konsentrasi, berbicara ketika belum siap, hal ini diketahui melalui analisis contoh-contoh kesalahan produksi ujaran. Mengatisipasi kesalahan produksi ujaran, selain berdampak pada produksi ujaran juga berdampak meningkatkan kemampuan public speaking. Apa yang didapatkan dari mengatisipasi kesalahan produksi ujaran adalah sikap dan sesuatu yang dibutuhkan untuk kemampuan public speaking yang lebih baik lagi, seperti mempersiapkan topik dengan baik, bersikap tenang, fokus, tidak berbicara ketika belum siap, hanya berbicara menggunakan kosa kata yang dikenal.
PEMANFAATAN NOVELTOON SEBAGAI MEDIA PEMBELAJARAN PROSA di SMA
Authors: Mulyaningtyas Rahmawati , Ekafebriyanti Valentina
Published: August 2022

Cybersastra atau sastra siber adalah aktivitas sastra yang memanfaatkan media elektronik atau internet. Sastra bergenre prosa sebagai salah satu sarana hiburan dan bahan pembelajaran saat ini dapat diakses melalui teknologi digital. Salah satu aplikasi daring yang dapat digunakan untuk mengakses prosa secara digital ialah NovelToon. Tujuan penelitian ini untuk menjelaskan cara penggunaan NovelToon, menjelaskan keunggulan dan kelemahan NovelToon, serta pemanfaatan NovelToon sebagaimedia pembelajaran prosa di SMA.Penelitian ini menggunakan pendekatan kualitatif. Metode penelitian ini menggunakan analisis isi (content analysis). Teknik dokumentasi dan catat merupakan teknik pengumpulan data dalam penelitian ini.Hasil penelitian ini menunjukkan bahwa penggunaan aplikasi NovelToon diawali dengan membuat akun pengguna, baik sebagai penulis maupun pembaca karya. Keunggulan NovelToon adalah fitur audio yang bisa ditambahkan pada setiap cerita sehingga pembaca dapat mendengarkan isi cerita selain membacanya. Di samping itu, adanya review karya dari tim NovelToon sehingga karya semakin berkualitas. Salah satu kelemahan aplikasi ini adalah bab cerita terbaru cenderung lama terbit tergantung pada durasi penilaian karya.Selain itu, mayoritas karya bergenre romantis. Pemanfaatan NovelToon sebagai media pembelajaran prosa dapat ditinjau dari pola dan strategi pemanfaatannya di dalam pembelajaran.
Pelatihan Pemanfaatan Sampah Plastik dan Limbah Rumah Tangga Sebagai Peluang Usaha bagi Remaja Desa Jetak Alastuwo
Authors: Alliffiantauri Adhik Audy , Fuad Hasyim
Published: August 2022

Saat ini limbah sampah plastik dan limbah rumah tangga masih menjadi masalah besar bagi kelestarian alam. Untuk menghindari pencemaran lingkungan maka perlu adanya pengolahan kembali limbah tersebut. Kegiatan pengabdian pada masyarakat yang bertema Penguatan Ketahanan Masyarakat Masa Pandemi Covid-19 Berbasis Kearifan Lokal dan Moderasi Beragama di Desa Jetak RT 3 RW 5 Alastuwo bertujuan untuk memberdayakan warga (remaja), memotivasi remaja untuk peduli dan cinta lingkungan, dan dapat menumbuhkan jiwa pemberdayaan remaja. Pengabdian masyarakat ini memberikan pelatihan mendaur ulang limbah plastik dan limbah rumah tangga dengan mengasah kreativitas masyarakat, sehingga sampah plastik bisa didaur ulang menjadi ecobrick atau bata ramah lingkungan. Selain itu pengolahan limbah rumah tangga seperti kulit telur dan kulit bawang dapat didaur ulang menjadi pupuk dan pestisida nabati. Metode yang pengabdi gunakan yakni observasi dan dokumentasi. Hasil dari pelatihan ini yakni warga (remaja) memiliki keterampilan dan kreativitas dalam mengolah sampah plastik dan limbah rumah tangga sehingga dapat nilai jual tinggi. Tujuan dari kegiatan pengabdian ini sudah tercapai, terbukti dengan adanya wawasan dan pengetahuan mengenai pengolahan sampah plastik dan limbah rumah tangga, keterampilan remaja membuat ecobrick, gantungan baju, pupuk dan pestisida, serta dengan sikap hidup remaja yang mau berusaha dengan keterampilan yang dimiliki mampu menambah pendapatan di tengah Pandemi Covid-19.
Pemahaman Pola Asuh Positif bagi Anak Usia Dini
Authors: Veryawan  , Rabitah Hanum Hasibuan  , Suhelayanti
Published: August 2022

Keluarga merupakan lingkungan pertama dan utama bagi anak. Dalam suatu keluarga, orang tua memiliki peran yang paling besar dalam memberikan pengaruh pada aspek perkembangan anak. Setiap orang tua tentu mempunyai pola asuh terhadap anak yang berbeda-beda, seperti pola asuh otoriter, pola asuh demokratis, dan pola asuh permisif. Banyak orang tua yang kurang memahami tentang pola asuh positif pada anak usia dini. Adanya kegiatan seminar parenting ini akan menambah pemahaman orang tua terhadap pola asuh yang positif terhadap anak usia dini. Metode yang digunakan dalam pengabdian kepada masyarakat ini adalah diskusi seminar parenting tentang pemahaman orang tua terhadap pola asuh positif. Seminar parenting ini dilaksanakan di KB Islam Al Hidayah Kota Langsa. Hasil dari kegiatan seminar parenting ini adalah orang tua sudah cukup memahami tentang pola asuh positif bagi anak usia dini.
Pelatihan Pembuatan Website Profil Madrasah di MTs Ma’arif Darul Hasan Polokarto pada Masa Pandemi Covid-19
Authors: Kholis Muhammad Nur , Hafidah  , Maslamah  , Ghofur Abdul
Published: August 2022

Pandemi Covid-19 yang melanda dunia termasuk Indonesia saat ini sangat berdampak terhadap berbagai sektor kehidupan masyarakat termasuk sektor Pendidikan. Pandemi mengubah sistem pendidikan yang semula mayoritas dilakukan secara tatap muka, berubah menjadi daring. Bagi Sebagian sekolah yang mempunya kemampuan finansial yang tinggi, perubahan ini dianggap sebagai sesuatu yang tidak terlalu mengejutkan, karena sekolah tersebut mempunyai fasilitas yang lengkap untuk menjalankan kegiatan secara daring. Sedangkan bagi sekolah yang belum mempunyai kemampuan finansial yang kuat hal tersebut menjadi sesuatu yang baru apalagi bagi sekolah yang baru berdiri. Sekolah yang baru berdiri hendaknya mempunyai fasilitas website untuk publikasi dan sosialisasi secara daring mengingat situasi saat ini sedang terjadi pandemi Covid-19. Maka kegiatan pelatihan pembuatan web profil madrasah media sosialisasi di masa pandemi Covid-19 di MTs Ma’arif Darul Hasan Polokarto mempunyai urgensi yang tinggi. Kegiatan pengabdian kepada Masyarakat ini dilakukan dengan tiga langkah yaitu analisis kebutuhan, tindakan dan evaluasi. Peserta dalam pelatihan ini adalah para guru yang berjumlah 24 orang. Hasil dari pengabdian ini berupa terselenggaranya pelatihan pembuatan web profil madrasah kepada para guru di MTs Ma’arif Darul Hasan Polokarto dengan minat dan antusiasme peserta yang tinggi dalam mengikuti kegiatan pelatihan tersebut.
PAST AND PRESENT OF İSTANBUL-BEBEK (HÜMAYÛNABÂD) MOSQUE
Authors: GİRAY KÜÇÜK Sezgi
Published: August 2022

Bebek semtinin simge yapılarından Bebek Camisi, 1725’te Bebek köyü kurulurken kırma çatılı, L plan şemalı bir köy camisi niteliğinde inşa edilmiştir. 1913 yılında ise bu cami yıkılarak yerine farklı bir plan şemasıyla, kubbeli, kâgir, revaklı, dikdörtgen planlı yeni bir cami, Mimar Kemalettin Bey tarafından tasarlanarak inşa edilmiş olup bu cami günümüzde de varlığını sürdürmektedir. Bu çalışmanın amacı, Boğaziçi’nin önemli kültür varlıklarından Bebek Camisi’nin inşasından günümüze geçirdiği değişimi gözler önüne sermektir. Bu kapsamda, Osmanlı ve Cumhuriyet Arşivi belgeleri, eski fotoğraf, gravür ve haritalar, Vakıflar 1. Bölge Müdürlüğü Arşivi’nde yer alan, caminin geçmiş dönem onarımlarına ilişkin dosyalar ve günümüz fotoğrafları kullanılmıştır. Yapılan incelemeler sonucunda, günümüzde ayakta olan Bebek Camisi’nin 1960 yılı onarımında, o dönemde yapılan pek çok eski eser onarımında görüldüğü gibi, çimento esaslı malzemeler ile onarıldığı, özgün alçı revzenlerin sökülerek çimento ile yenilendiği, sıvalarda ve harçlarda çimento kullanıldığı, bu sebeple ve deniz kenarında konumlanması sebebiyle tuz kristallenmesi (çiçeklenme) probleminin yapının genelinde görüldüğü tespit edilmiştir. Bunun yanı sıra plan şemasında yapılan değişiklikler de caminin özgünlükten uzaklaşmasına sebep olmuştur. 2019-2022 restorasyonuyla yapının planı özgün haline getirilmiş, olumsuz tuz etkisi ve diğer problemler giderilerek cami onarılmıştır. Bu çalışmada, bir Cumhuriyet dönemi yapısı olan Bebek Camisi ile sembolize edilmekte olan Bebek semtinin tarihinin aslında çok daha eskiye dayanmakta olduğu ve günümüzde görülen Bebek Camisi’nin yerinde 18. yüzyılda, kırma çatılı bir caminin olduğu gözler önüne serilmek istenmiştir. Hangi döneme ait olursa olsun kentin geçmişinde yeri olan kültür varlıkları korunmalı, özüne uygun malzeme ve tekniklere restore edilerek gelecek kuşaklara aktarılmalıdır.
SUSPECTED CASE OF ERYTHEMA MULTIFORME MAJOR CAUSED BY COMBINATION THERAPY OF GLIMIPRIDE, VOGLIBOSE, AND METFORMIN WITH CLOMIPHENE CITRATE IN POLYCYSTIC OVARY SYNDROME AND TYPE 2 DIABETES PATIENT IN INDIA
Authors: Kumar Hardik , Gangwar Ruby , Kumar Arvind , Sharma amit
Published: August 2022

This present case report will help all healthcare professionals aware
and vigilant about the adverse drug reaction caused by drug combination
glimipride, voglibose, metformin, and clomiphene citrate.
Changes in Global Warming Potential induced by vegetation restoration on the Loess Plateau, China
Authors: Wang Ke , Zhao Dongsheng , Zhu Yu , Cui Yaoping
Published: August 2022

The vegetation cover of the Loess Plateau in China has been markedly
restored through implementation of land management measures and
ecological engineering. Previous studies of the effects of vegetation
restoration on climate focused primarily on carbon sequestration and
ignored biogeophysical effects. In this study, we used remote sensing
data from 2001–2017 to quantify land cover change, vegetation
restoration, and the corresponding differences in radiative forcing
(RF). Furthermore, we derived the carbon dioxide (CO )
equivalent for vegetation restoration from the 100-year global warming
potential (GWP). Our results showed that cropland and forestland areas
increased continuously from 2001–2017, with positive average rates of
13.76% and 33.24% per year, respectively. Vegetation greenness
(expressed as the Normalized Difference Vegetation Index) also showed an
increasing trend, indicating a gradual increase in vegetation activity.
Conversely, surface albedo showed a decreasing trend closely related to
the vegetation greenness increase. During the whole study period, both
RF and GWP showed an increasing trend, with average annual rates of 0.13
W/m /yr and 0.19 kgCO /m
/yr, respectively. The global average RF was 1.58 W/m
and the global average GWP was 3.7 kgCO
/m . Vegetation restoration on the
Loess Plateau induced an overall decrease in surface albedo, thus an
increase in surface energy, or warming effect, equivalent to an emission
of 3.7 kgCO /m . We concluded that
it is essential to consider the biogeophysical effect of vegetation
restoration when quantifying the global effect of vegetation on climate.
Do the size, site and activity of tympanic membrane perforations relate to hearing loss in Aboriginal and Torres Strait Islander children? An observational study.
Authors: Morris Jack , Lee Zoe , Carney Andrew , Sanchez Linnett
Published: August 2022

Objective: To investigate the effect of size, site and activity of
tympanic membrane (TM) perforation on hearing loss (HL) in Aboriginal
and Torres Strait Islander (ATSI) children. Design: Observational study
Methodology: Children aged 5-18 years who identified as ATSI at 7 Anangu
community schools within the APY Lands and Maralinga Lands of South
Australia underwent 4 frequency pure-tone audiometry (0.5, 1, 2 and
4kHz) and video-otoscopy (VO). VO data was reviewed by surgeons for a
middle ear diagnosis and VO files with TM perforations were then
classified by perforation site (AS, AI, PS, PI, A, P, I) and size
(<25%, 25–50%, 50–75% or 75–100%). Results: 575 VO
files with matching audiological data were obtained. Active perforations
(35dBHL; 28-44 IQR) demonstrated greater HL than inactive perforations
(31dBHL; 29-39 IQR) p=0.0029. For inactive perforations there was a
significant difference between <25% and all larger
perforations (p<0.0001) whereas for active perforations the
significance changed to between <25% (p<0.0001) and
25-50% (p<0.05) when compared to larger perforations. When
perforation site was compared within all size/activity groups, no
statistically different findings were identified. In all analyses
findings did not change when individual frequencies were compared to
4-frequency pure tone average dBHL. Conclusion: In ATSI children from
remote communities HL is greater in ears with larger perforations and
active middle ear disease but there was no relationship between
perforation site and HL.
Type 2 Diabetes, Independent of Obesity and Age, Is Characterized by Senescent and Dysfunctional Mature Human Adipose Cells
Authors: Gustafson Birgit , Nerstedt Annika , Spinelli Rosa , Beguinot Francesco , Smith Ulf
Published: August 2022

Obesity with dysfunctional adipose cells is the major cause of the current epidemic of type 2 diabetes (T2D). We examined senescence in human adipose tissue cells from age- and BMI-matched individuals who were lean, obese, and obese with T2D. In obese individuals and, more pronounced, those with T2D, we found mature and fully differentiated adipose cells to exhibit increased senescence similar to what we previously have shown in the progenitor cells. The degree of adipose cell senescence was positively correlated with whole-body insulin resistance and adipose cell size. Adipose cell protein analysis revealed dysfunctional cells in T2D with increased senescence markers reduced PPAR-γ, GLUT4, and pS473AKT. Consistent with a recent study, we found the cell cycle regulator cyclin D1 to be increased in obese cells and further elevated in T2D cells, closely correlating with senescence markers, ambient donor glucose, and, more inconsistently, plasma insulin levels. Furthermore, fully differentiated adipose cells were susceptible to experimentally induced senescence and to conditioned medium increasing cyclin D1 and responsive to senolytic agents. Thus, fully mature human adipose cells from obese individuals, particularly those with T2D become senescent, and SASP secretion by senescent progenitor cells can play an important role in addition to donor hyperinsulinemia.
Symptoms of Anxiety and Depression Are Independently Associated With Impaired Awareness of Hypoglycemia in Type 1 Diabetes
Authors: Pieri Beatrice A. , Bergin-Cartwright Gabriella A.I. , Simpson Anna , Collins Julian , Reid Anna , Karalliedde Janaka , Brackenridge Anna , Hotopf Matthew , Hussain Sufyan
Published: August 2022

OBJECTIVE

We tested the hypothesis that impaired awareness of hypoglycemia (IAH) is independently associated with symptoms of anxiety and depression in type 1 diabetes.

RESEARCH DESIGN AND METHODS

In this cross-sectional observational study in 950 adults with type 1 diabetes, associations were examined using multiple regression models, adjusting for sociodemographic and clinical characteristics.

RESULTS

Prevalence for probable anxiety, depression, and IAH were 9.4%, 9.8%, and 22.6%, respectively. When included in separate regression models, both depression and anxiety were independently associated with an increased odds of IAH and robust to adjustment (odds ratio 3.64 [95% CI 2.19–6.04] and 2.46 [1.46–4.14], respectively). Further analysis demonstrated a dose-response relationship between increased severity of probable mental disorder and increased odds of having IAH (P < 0.001).

CONCLUSIONS

The robust independent relationship between probable anxiety and depression with IAH demonstrates the need for routine psychological assessment and management of people with type 1 diabetes and IAH.
Symptoms of anxiety and depression are independently associated with impaired awareness of hypoglycaemia in type 1 diabetes
Authors: Pieri Beatrice A. , Bergin-Cartwright Gabriella A. I. , Simpson Anna , Collins Julian , Reid Anna , Karalliedde Janaka , Brackenridge Anna , Hotopf Matthew , Hussain Sufyan
Published: August 2022

  

OBJECTIVE 

We tested the hypothesis that impaired awareness of hypoglycemia (IAH) is independently associated with symptoms of anxiety and depression in type 1 diabetes.

RESEARCH DESIGN AND METHODS

Cross-sectional observational study in 950 adults with type 1 diabetes. Associations were examined using multiple regression models, adjusting for sociodemographic and clinical characteristics. 

RESULTS

Prevalence for probable anxiety, depression and IAH were 9.4%, 9.8%, and 22.6%, respectively. When included in separate regression models, both depression and anxiety were independently associated with increased odds of IAH and robust to adjustment, OR 3.64(95% CI 2.19–6.04), and OR 2.46(95% CI 1.46–4.14) respectively. Further analysis demonstrated a dose-response relationship between increased severity of probable mental disorder and increased odds of having IAH (p<0.001). 

CONCLUSIONS 

The robust independent relationship between probable anxiety and depression with IAH demonstrates the need for routine psychological assessment and management of people with type 1 diabetes and IAH. 
2021 Census to Census Coverage Survey Matching Results.
Authors: Tomlin Charlie , Edwards David
Published: August 2022

The 2021 England and Wales Census was matched to the Census Coverage Survey (CCS). This was an essential requisite for estimating undercount in the Census. To ensure outputs could be produced within a year of census day, matching had to be completed in eight weeks.

We used the Data Access Platform to write efficient and accurate automatic matching algorithms. Probabilistic and associative matching methods were used to present candidate pairs that could not be automatically matched but likely consisted of many true matches. These were resolved by matchers in the clerical matching system. Active learning was used to iteratively improve probabilistic parameters as matches were made.

We also developed a pre-search algorithm that simplifies clerical matching by replacing clerical searching (here’s a record, can you find a match?) with clerical resolution (here are two records, do they match?).

As a result of our improvements, we increased our automatic matching rates from 70% (2011 Census) to 93% (2021 Census) for person matching and from 60% to 95% for household matching, without loss of accuracy. Precision and recall were estimated to both be 99.96% for person matching and 100% and 99.78% respectively for household matching. For both persons and households, the same trends seen in 2011 are seen here too; however, most of the biases have decreased and most match rates have increased.

Dual system estimation using the matched and unmatched records enabled us to estimate that coverage in the 2021 England and Wales Census was 97%.

The matching methodology implemented for the 2021 Census to CCS matching improved both person and household matching greatly when compared with the 2011 matching. The clerical matching system enabled clerical matching at scale and at pace. Thus, we successfully completed all clerical matching within our eight-week deadline.
Neonatal mortality in NHS maternity units by timing of birth and method of delivery: a retrospective linked cohort study.
Authors: Carty Lucy , Cortina-Borja Mario , Plachcinski Rachel , Grollman Chris , Macfarlane Alison
Published: August 2022

ObjectivesPotential ‘weekend effects’ in healthcare prompt concerns that care could be of lower quality during non-working hours, but may reflect differences in case mix or other factors This research aimed to compare neonatal mortality in English hospitals from 2005 to 2014 by time of day and day of the week.

ApproachWe analysed data from a retrospective cohort of 6,054,536 singleton births in England 2005—2014, created by linking ONS birth and death registration and birth notification data with Hospital Episode Statistics.

Working hours were defined as 07:00—19:00 on weekdays, and non-working hours were all other times on weekdays and all weekends and public holidays.

The primary outcome was all-cause neonatal mortality unattributed to congenital anomaly. We also modelled cause-specific neonatal mortality attributed to asphyxia, anoxia or trauma (AAT). On advice through our public involvement and strategy, analysis was stratified by mode of onset of labour and method of delivery.

ResultsAfter adjustment for confounders, the odds of all-cause neonatal mortality outside of working hours were similar to those during working hours for spontaneous births, instrumental births and emergency caesareans. Planned caesareans occurring in non-working hours had a high crude risk compared to planned caesareans in working hours, but were considered to be unreliably recorded and likely to reflect emergency caesarean delivery of babies originally scheduled for planned caesarean birth.

Further stratification of emergency caesareans by onset of labour showed higher odds of cause-specific neonatal mortality (AAT) during non-working compared with working hours for emergency caesareans without labour recorded but not for emergency caesareans after spontaneous or induced onset of labour.

ConclusionIt may be that the apparent ‘weekend effect’ is caused by deaths among the relatively small number of babies who were born by caesarean section apparently without labour outside normal working hours. Obstetric staffing should be planned to allow for these relatively unusual emergencies.