bluuebunny/crossref_metadata_2025 huggingface dataset:
The temporality of remaining trapped. Beauvoir on aging as a gendered phenomenon
Authors: Čičigoj Katja , Miglio Nicole
Published: February 2025

In this contribution, we discuss the phenomenon of aging as gender-based with the help of Beauvoir’s account of aging, temporality, and gender. We explore how the social centring of the reproductive capacities of women’s bodies impacts the ways in which they might tend to experience growing old. The first section frames our analysis within Beauvoir’s philosophical project and thus poses the issue of elderly women as people who cease being able to fulfil their reproductive ‘duties’ in patriarchal societies; in the second section we stress the relationship between temporality and gender as transcendental structures of the self. This methodological basis allows us to explore in the third section the core of the Beauvoirian thesis by addressing the existential dimension of aging for women, who still have – even in an advanced age – to navigate challenging experiences related to sexuality and reproduction.
Anthrax Surveillance and Analysis Protocol v1
Authors: A Chari Tawanda , Gufe claudious
Published: February 2025

This study employs a systematic review and retrospective analysis to assess anthrax incidence, prevalence, and risk factors in Zimbabwe. Data were sourced from peer-reviewed literature, grey veterinary records from the Central Veterinary Laboratory (CVL), and geospatial analysis using GIS. Anthrax prevalence was estimated using weighted prevalence analysis, with a calculated regional prevalence of 17.33% across Zimbabwe, Kenya, Botswana, and Namibia. Logistic regression modelling was applied to examine climate influences, revealing a positive correlation (OR = 2.41, p < 0.05) between outbreaks and post-drought rainfall events. Spatial analysis identified high-risk zones in Midlands, Mashonaland Central, and Matabeleland North using the Getis-Ord Gi hotspot detection method*. This methodology provides a reproducible framework for anthrax surveillance, incorporating epidemiological, statistical, and GIS-based approaches to inform climate-adaptive risk mapping and targeted intervention strategies.
Analysis of Vulnerabilities in the Automatic Reconnection of Devices to Known Wi-Fi Networks
Authors: Vázquez-Naya Jose , Santiago-Cernadas Daniel
Published: February 2025

While modern Wi-Fi security protocols such as WPA2-PSK and WPA3-PSK enhance encryption to protect against password cracking and packet sniffing, they may still be vulnerable to certain attacks. Specifically, under certain conditions, an attacker could spoof a legitimate access point (AP) to establish a man-in-the-middle (MitM) attack. This study investigates whether different devices are able to distinguish between legitimate and spoofed APs, and examines how they respond to such impersonation attempts. By analyzing device behavior in these scenarios, we aim to assess the effectiveness of current security measures and highlight potential vulnerabilities in Wi-Fi network reconnection mechanisms.
Key Principles Involving Ethical and Deontological Issues in Military Stress Management Training in Virtual Reality Environments
Authors: Pereira Javier , Marques António , Curado Henrique , Vianez Ana , Veloso Gomes Paulo
Published: February 2025

The integration of Virtual Reality in military contexts, which simulates realistic combat and high-risk operational scenarios, provides a controlled environment for developing various skills and psychological resilience. This technology has proven to be a valuable tool for enhancing soldiers' training and preparedness. The creation and use of VR programs, especially those involving the collection of biofeedback data to study military stress, carry significant ethical and deontological responsibilities. This study examines the regulation of using powerful algorithms to analyse biofeedback data to study military stress, emphasizing informed consent, privacy and confidentiality, beneficence and nonmaleficence, transparency in data usage and compliance with legal and regulatory standards.
Estimation of Cardiotoxicity in Breast Cancer Patients Using Presmoothing and Cure Models
Authors: Jácome María Amalia , López-Cheda Ana , Saavedra Samuel
Published: February 2025

Breast cancer is the most common type of cancer for women. Nowadays, the side-effects that some treatments against this type of cancer can be a major problem. One example of this is HER2-positive breast cancer patients. Patients are prescribed trastuzumab, a drug with anti-tumour efficacy, but this treatment can cause various undesirable effects such as heart problems, known as cardiotoxicity. With the aim of improving the quality of life of those affected, the question is clear: what is the likelihood of suffering cardiotoxicity? In this work, this probability is estimated using a new approach to the classic cure models: the presmoothed cure models.
Orthogen Autologous Conditioned Serum: An Update of the currently published Clinical Studies
Authors: Hang Nicole , Hamed Glyn , Wehling Jana , Reinecke Julio , Hang Minna
Published: February 2025

Orthogen Autologous Conditioned Serum is a proven non-recombinant autobiological therapeutic for local treatment of pain, inflammation and tissue injury, functional both in humans and animals. Unlike other autobiologics, Orthogen-ACS stands out wielding the full spectrum of mediators released from all cells present in whole blood, the blood cell secretome. Through a process of extended coagulation of whole blood, Orthogen-ACS contains a unique composition of mediators including but not limited to growth factors, cytokines, lipid mediators, mitochondrial derived peptides and extracellular vesicles. Release of these mediators is triggered by the “tissue” blood when artificially confronted with the tasks Stop bleeding, Fend off pathogens and Initiate healing. The clinical effectiveness of local injection treatment with Orthogen-ACS has been shown in a multitude of clinical indications incl. osteoarthritis, radiculopathy, tendinopathy, muscle strain, ligament, meniscal tear, wound healing and others. This review reports on the 44 published human clinical studies dating from early 2000 until recent. Several of these publications report small case number; however, strong clinical evidence exists for knee osteoarthritis, followed by lower back pain and radiculopathy. This broad spectrum of indications suggests that ACS mode of action has profoundly regenerative and immune-modulating properties. In conclusion, ACS therapy is efficacious, safe, simple to process. Orthogen-ACS appears to activate a wide variety of pathways that converge on the attempt of tissue repair and regeneration.
The Growth of the Diversity of social Interests in and Problems of Governance in Information society
Authors:   Saratov State University, Kuznetsov A.V.
Published: February 2025

The article examines the idea of diversity of social interests as a factor
that influences on a quality of governance and a level of democracy
in political system. Author analyzes different versions of reducing the
system of governance to necessary level of complexity by the reason
of complication of governance object.
Genesis of Agrarian sociology in Russia
Authors:   Saratov State University, Antonov V.B.
Published: February 2025

The article examines the history of Russian agrarian sociology, stages
of its development and its present-day state.
Political Elite Concept in the Light Contemporary sociological Representations
Authors:   Saratov State University, Pokatov D.V.
Published: February 2025

In the article the peculiarities of the contemporary sociological representations about concept «political elite» are considered.
The contribution of the representatives of different sociological schools in developing characteristic
features of the concept «political elite» and the analyses of it's essence was determined. In this
article the autor 's interpretation of the mention above concept was given.
Globalization of the Russian system of Higher Education: Main Directions
Authors:   Saratov State University, Retrovich O.G.
Published: February 2025

The paper analyzes various ways of definition what globalization of
education is – internationalization, integration, informatization or
westernization. Moreover it briefly analyzes necessity, implementation
and efficiency of these processes in conditions of gradual globalization
of Russian system of higher education.
F.M. Dostoevsky’s «The Writer’s Diary»: Characteristics of Memoir Component
Authors:   Saratov State University, Tzelovalnikova D.N.
Published: February 2025

The memoir pages of “The Writer’s Diary” reflect the public and political
side of Dostoevsky – the man of letters, where the universal and the
private are characteristically for “The Diary…” closely interwoven. The
pages devoted to Dostoevsky’s contemporary authors in particular
help to see deeper into the literary process of the period.
«Plots in the Form of Dialogue»: Author’s notes in Turgenev’s Plays. Aspect of Interpretation
Authors:   Saratov State University, Zorin A.N.
Published: February 2025

Turgenev’s drama work results from his experiments with genre. In
the period of crisis in the Russian theatre, he aimed at searching for
the new stage forms. Psychological plays, the comedy hiding the
archetypal plots of classical tragedy, free mix of traditional plots – all
these are coded in author’s stage-directions, defining the genre. For
more than a century the scholars of Turgenev’s plays attempt to break
these codes.
Certain Aspects of the Poetic Image Functioning in Zabolotskiy’s Early Poetry
Authors:   Saratov State Social and Economic University, Kekova S.V.
Published: February 2025

The article deals with the peculiar imagery in Zabolotskiy’s early
poetry, which is characterized by specific paradoxical and abnormal
semantics. The analysis of macroimages woman and horse in
Zabolotskiy’s poetic works reveals the regularities of the genesis of
the absurd reality.
Urgent Political Problems as seen by Saratov Region Citizens (the Results of sociological Polls)
Authors:   Saratov State University, Vilkov A.A. , Danilov M.B. ,   Saratov State University, Kazakov A.A. ,   Saratov State University, Poponov D.V. ,   Saratov State University
Published: February 2025

The article represents analytical surveys of the sociological polls’ materials which were fulfilled
by the Political Research laboratory of the Chair of Political Science. In the paper main values of
the population were estimated, the level of support of the definite Russian political parties were
analyzed and the principal ideological preferences of different social groups were characterized.
Das Feuilleton im Verständnis Joseph Roths, seine Entwicklungsphasen sowie die Zusammenarbeit Roths mit der Exilpresse
Authors: Gołaszewski Marcin
Published: February 2025

Joseph Roth (1984–1939) belonged to a generation that was affected by two world wars, the collapse of the old world order, emerging nationalism and forced emigration. Columns, journalistic activity and literary works were an expressions of growing frustration, escape from the world, resignation and one’s own helplessness. The columns are a perfect mirror of the changes that have occured in the writer over the decades. At the same time, they became an expression of emotions and experiences and manifested them in various forms and styles of artistic expression. The definition of the feature section, in the sense Joseph Roth understands, stylistic influences on his work and its characteristic features, cooperation with the exile press are the components of the article understood as an attempt to outline the general characteristics of the genre in the author’s work.
Military Engineers and Artillery Production in Milan Under the Sforza (1450–1535). Institutions, Professionalism, Techniques
Authors: Ronchi Matteo
Published: February 2025

The late 15th-century Milanese army boasted an impressive artillery park of several heavy bombards and a multitude of light field artillery pieces. Such war machines were manufactured and operated by the specialised personnel of the ‘ducal munitions and public works office’, i.e., engineers recruited among both Lombards and foreigners, supervised by a general commissar. Unfortunately, the study of Milanese firearms production and its political and diplomatic implications remain practically uninvestigated among contemporary historians, except for a few important studies from the 19th and 20th centuries.
Thanks to the epistolary documentation contained in the archival series Ingegneri e architetti, conserved in the State Archive of Milan, this contribution will focus on providing an overview of the activities of the ammunition office, the professional backgrounds of its engineers and their skill sets, as well as gunmaking processes, production sites, and techniques. Finally, this contribution will stress the impact of artillery production on the Italian and broader European political culture of the time: even in times of peace, the art of gunmaking and its products shaped the diplomatic and economic relations between Italian and other European states, via the constant exchange of specialised gunsmiths and the diffusion of innovative military technology.
K4DD Mpox Health Evidence Summary No 11
Authors: Mujuru Sithandiwe
Published: February 2025

Bi-weekly Mpox Health Evidence Summaries aim to signpost FCDO and others to the latest relevant evidence on Mpox.
Pathogens and diseases affecting large-scale production of black soldier fly
Authors:   University of Florida, USA, Pereira Roberto M.
Published: February 2025

Black soldier flies (BSF) (Hermetia illucens, Diptera: Stratiomyidae) are produced on a large scale using various production methods and food substrates. This chapter reviews organisms that have true pathogenic relationships with the BSF which could cause negative effects on insect culture. These includes viruses, bacteria, fungi, protists and nematodes. The chapter looks at how managing rearing conditions can reduce disease risk as well as specific disease prevention and control measures.
Advances in nutrient/substrate sources/composition for rearing yellow mealworms as a protein source
Authors:   Porto Conte Ricerche S.r.l., Italy, Melis Riccardo , Anedda Roberto ,   Porto Conte Ricerche S.r.l., Italy
Published: February 2025

This chapter focuses on the impact of various substrates on the nutritional quality – in particular protein content - of the yellow mealworm larvae. The authors begin by describing the characteristics of rearing substrates for optimal yellow mealworm growth, including nutritional composition, biomass production, and feed conversion ratio. Next they analyse the yellow mealworm\'s protein content, and consider factors which may influence it. Finally the chapter touches on factors influencing the use of novel biomasses as substrates to increase the yellow mealworm proteins content, and discuss how the yellow mealworm has proven to be able to degrade polymer bio-plastics, thus opening new interesting opportunities to address the global plastic waste problem.
Level of Knowledge of Adolescent Girls of Madrasah Aliyah Pesantren Islam Al-Mukmin Ngruki Sukoharjo on Bullying Behavior
Authors: Kusmiasari Irma Dwi , Basworo Wikan , Artanti Martiana Sucingtyas Tri , Priyambodo Dewanto Yusuf , Pidada Ida Bagus Gede Surya Putra , Poga Adam Juan
Published: February 2025

Bullying is an aggressive behavior carried out intentionally and repeatedly, causing the victim to feel hurt and oppressed. This phenomenon is still prevalent among Indonesian adolescents, including in Islamic boarding schools, which are supposed to be centers for instilling Islamic values. This study aimed to describe the level of knowledge about bullying among female students at Madrasah Aliyah (MA) Pondok Pesantren Islam Al-Mukmin Ngruki Sukoharjo. The research utilized a descriptive quantitative method, targeting female students in grade XI. A total of 129 respondents were involved using total sampling, and data were collected through questionnaires and analyzed descriptively. The results revealed that most female students had a good level of knowledge. Based on majors, the highest knowledge level was found among students in religious studies (98.3%), while based on region, students from outside Solo dominated the good category (97.1%). Raising awareness about bullying can be done through early education that includes its definition, types, effects, and ways to prevent it. These findings can also serve as baseline data for comparing bullying levels among male and female adolescents
Edukasi Penyakit Asam Urat di Desa Dawung Wetan Surakarta
Authors: Wikantyasning Erindyah Retno , Wahyuni Arifah Sri , Julianti Tri Budi , Amalia Nastity Zhahwa , Astuti Devi Dwi
Published: February 2025

Prevalensi penyakit tidak menular, termasuk asam urat, semakin meningkat di Indonesia. Pengabdian kepada masyarakat ini menguraikan pelaksanaan kegiatan pengabdian kepada masyarakat yang difokuskan pada penyuluhan penyakit asam urat di Kelurahan Dawung Wetan, Kota Surakarta, Provinsi Jawa Tengah. Penyuluhan ini bertujuan untuk meningkatkan pemahaman masyarakat tentang penyakit asam urat dan mendorong praktik hidup sehat. Metodologi yang digunakan adalah penyuluhan tentang faktor risiko penyakit asam urat kepada ibu-ibu PKK. dan pencegahan penyakit, dilanjutkan dengan sesi tanya jawab, pemberian pretest sebelum penyuluhan, dan posttest setelah penyuluhan untuk menilai tingkat pengetahuan masyarakat. Hasil penelitian menunjukkan bahwa 66,7% peserta memiliki pemahaman yang komprehensif tentang asam urat, sedangkan 33,3% menunjukkan pengetahuan yang memadai. Temuan ini menunjukkan bahwa edukasi yang disampaikan memberikan pemahaman ibu-ibu PKK tentang asam urat meningkat terlihat dari jawaban pretest dan posttest yang diberikan. Meskipun demikian, temuan ini juga memberikan arahan untuk meningkatkan inisiatif edukasi dan pencegahan. Upaya pengabdian masyarakat ini secara efektif meningkatkan pengetahuan masyarakat tentang asam urat dan mendorong penerapan gaya hidup sehat. untuk mewujudkan masyarakat yang lebih sejahtera dan berkualitas. Kata Kunci: Edukasi, Asam Urat, Gaya Hidup Sehat, Kesehatan The prevalence of non-communicable diseases, including gout, is rising in Indonesia. This community service outlines the execution of community service initiatives centred on gout education in Dawung Wetan Village, Surakarta City, Central Java Province. This counselling seeks to enhance public comprehension of gout and encourage healthy lifestyle practices. The methodology entails instructing PKK moms on risk factors and disease prevention, succeeded by a question and answer session, the administration of a pretest prior to counselling, and a posttest subsequent to counselling to assess the community's knowledge level. The findings indicated that 66.7% of participants possessed a comprehensive awareness of gout, whilst 33.3% demonstrated adequate knowledge. These findings suggest educational initiatives aimed at enhancing public comprehension of gout. Nonetheless, these findings also offer direction for enhancing educational and preventive initiatives. This community service effort effectively enhances public knowledge about gout and promotes the adoption of healthy lifestyles to cultivate a more prosperous and quality society.
Pembuatan Perangkap Tikus Semi Otomatis Dengan Sensor Gerak
Authors: Nurdi Mi’rajzul Hudia , Pramudi Muhammad Indar , Marsuni Yusriadi
Published: February 2025

Dalam usaha meminimalisir dampak negatif pemakaian bahan kimia untuk memberantas tikus, maka perlu dicari alternatif pengendalian lain dengan menggunakan perangkap. Banyaknya alat perangkap tikus konvensional yang kurang efektif dalam penggunaannya dapat menjadi bumerang bagi diri sendiri. Menyikapi Permasalahan ini, penulis mencoba merancang perangkap tikus semi otomatis yang digabungkan dengan sensorik (gerak). Tujuan dari penelitian ini adalah Pembuatan perangkap tikus semi otomatis serta berbagai desain untuk mengetahui yang lebih efektif untuk menjebak tikus. Metode yang digunakan dalam penelitian ini dengan pengendalian perangkap yang dilakukan di persawahan. Pemasangan perangkap di uji coba keefektifan sensoriknya. Hasil dari penelitian ini menunjukan bahwa sensor gerak yang terpasang pada perangkap mendeteksi adanya pergerakan yang terlihat pada aplikasi android dan berhasil memerangkap tikus.
Efektivitas Kombinasi Bakteri Streptomyces sp Dengan Pestisida Nabati Daun Sirih Dan Daun Kelakai Terhadap Penyakit Antraknosa Pada Cabai Hiyung
Authors: Erlangga Muhammad Dede , Budi Ismed Setya , Mariana Mariana
Published: February 2025

Cabai merupakan komoditas yang mengalami fluktuasi harga akibat tingginya permintaan. Pada 2021 produksi cabai rawit di Indonesia turun 8,09% dibanding 2020. Penyakit antraknosa disebabkan oleh jamur Colletotrichum sp., dapat menurunkan produktivitas hingga 5-30%, bahkan menyebabkan gagal panen. Pengendalian hayati menggunakan Streptomyces sp. dan pestisida nabati seperti daun sirih dan daun kelakai adalah alternatif ramah lingkungan. Penelitian ini mengevaluasi efektivitas kombinasi tersebut terhadap antraknosa pada cabai hiyung. Hasil penelitian menunjukkan bahwa aplikasi bakteri Streptomyches sp., pestisida nabati Daun Kelakai, pestisida nabati Daun Sirih dan kombinasinya  mampu menurunkan kejadian penyakit antraknosa dengan kejadian penyakit berkisar 15.05%-21.33% dibandingkan kontrol yang kejadian penyakitnya 33.24%. Hasil analisis efektivitas pengendalian penyakit terdapat 4 perlakuan yang cukup efektif yaitu Sirih 54.72%, Streptomyces sp. 46.48%, kombinasi Sirih dan Streptomyces sp. 43.65%, serta kombinasi kelakai dan Streptomyces sp 40.94%. Hasil pengamatan juga menunjukkan bahwa perlakuan pestisida nabati Sirih adalah perlakuan terbaik dalam menghasilkan tanaman tertinggi 30.56 cm dan meningkatkan berat basah dengan hasil 83.38 g, diikuti dengan perlakuan Kelakai yang juga menghasilkan hasil panen tertinggi 82.03 g. Selain itu, seluruh perlakuan yang diberikan mampu mempercepat umur pembungaan cabai 56.08-57.52 hari dibandingkan kontrol selama 58.28 hari.
Analisis pengaruh Indeks Pembangunan Manusia (IPM), rasio gini, Tingkat Pengangguran Terbuka (TPT) dan upah minimum terhadap jumlah penduduk miskin di Provinsi Daerah Istimewa Yogyakarta tahun 2014-2023
Authors: Setya Mega Rosaline Tri , Tohirin Achmad
Published: February 2025

Purpose – This study aims to determine the influence of IPM, Gini Ratio, TPT and Minimum Wage on the number of poor people in Yogyakarta Special Region Province.Methods – This study uses a panel data model that combines time series data for 2014-2023 and cross-section data in 5 districts/cities in the Special Region of Yogyakarta Province.Findings – The results of this study show that IPM and the Gini Ratio have a significant and positive effect on the number of poor people. In contrast, TPT and Minimum Wage have a significant and negative impact on the number of poor people in Yogyakarta Special Region Province.Implication – The government is expected to be able to optimize development programs in the health, education and economic sectors which can provide direct benefits for the poor and maintain the policy of setting minimum wages. Originality – This study contributes to developing empirical studies on poverty in the Special Region of Yogyakarta Province using a panel data approach.
AbstrakTujuan – Penelitian ini bertujuan untuk mengetahui pengaruh IPM, Rasio Gini, TPT dan Upah Minimum terhadap jumlah penduduk miskin di Provinsi Daerah Istimewa Yogyakarta. Metode – Penelitian ini menggunakan model data panel yang menggabungkan data time series tahun 2014-2023 dan data cross section pada 5 Kabupaten/Kota di Provinsi Daerah Istimewa Yogyakarta.Temuan – Hasil dari penelitian ini menunjukkan bahwa IPM dan Rasio Gini berpengaruh signifikan dan positif terhadap jumlah penduduk miskin, sedangkan TPT dan Upah Minimum berpengaruh signifikan dan negatif terhadap jumlah penduduk miskin di Provinsi Daerah Istimewa Yogyakarta. Implikasi – Pemerintah diharapkan dapat mengoptimalkan program pembangunan pada bidang kesehatan, pendidikan, dan ekonomi yang dapat memberikan manfaat secara langsung bagi para penduduk miskin serta mempertahankan kebijakan penetapan upah minimum.Orisinalitas – Penelitian ini berkontibusi pada pengembangan kajian empiris tentang kemiskinan di Provinsi Daerah Istimewa Yogyakarta dengan menggunakan pendekatan data panel.
Novel Approach to Enhancing Brain DHA Uptake: The Role of Nannochloropsis Microalgae Extract
Authors: Ma Kunpeng , Xie Shuhui , Zhang Ying , Liu Haixiang , Yu Wei , Chen Peihua
Published: February 2025

Docosahexaenoic acid (DHA) plays a pivotal role in sustaining the normal function of human brain and preventing metabolic and neurodegenerative disorders. Despite its significance, the bioavailability of DHA from current supplements is suboptimal due to limited uptake capacity of adult brain. Recent studies have highlighted the role of Mfsd2a transporter in facilitating brain uptake of DHA when esterified to lyso-phosphatidylcholine (LPC). Lyso-diacylglyceryltrimethylhomoserine (LDGTS), a betaine lipid that resembles LPC in structure and is abundant in Nannochloropsis microalgaeoil, presents a promising alternative for enhancing DHA uptake. This study aimed to examine whether LDGTS-containing microalgae oil can increase DHA level by the brain. We established 8 groups of mice fed with different lipid materials for comparison in addition to their regular diet. After 15 days of feeding, and tissue and organ samples of mice were collected for lipid extraction and fatty acid analysis. The mice fed a mixture of microalgae oil and triacylglycerol (TAG)-DHA showed a significant increase in DHA uptake in the brain compared to control. This effect was not observed when mice were administered with TAG-DHA alone, microalgae oil alone, or krill oil. The facilitation of DHA incorporation was accompanied by a notable enhancement of pathways related to cell growth and retinol metabolism in the brain, while pathways associated with cellular apoptosis and inflammation were downregulated. Thus, the inclusion of LDGTS-rich microalgae oil in DHA supplementation may offer a novel and effective strategy for improving the bioavailability of DHA in the brain.
Extravascular leakage of dexrazoxane during treatment of diffuse large B-cell lymphoma: A case report
Authors: Wakamiya Nao , Suzuki Masanori , Isezaki Tatsuya , Funakoshi Ryohkan
Published: February 2025

Background: Dexrazoxane is used to treat extravascular leakage of anthracycline antitumor agents, but its own extravascular leakage and management remain underreported. This case aimed to highlight both doxorubicin and dexrazoxane leakage during treatment for diffuse large B-cell lymphoma.
Case presentation: A 55-year-old man with diffuse large B-cell lymphoma developed doxorubicin leakage during R-CHOP therapy, which was treated with dexrazoxane. Subsequently, dexrazoxane leakage occurred, causing erythema and swelling. Topical clobetasol propionate was applied, leading to symptom resolution without necrosis. The patient successfully completed chemotherapy and achieved long-term remission.
Conclusions: This case report is one of the first to document the management of dexrazoxane extravascular leakage using topical steroids, effectively preventing severe outcomes. The findings suggest that topical steroids may be a desirable treatment approach for dexrazoxane leakage. Prompt intervention and interdisciplinary care contributed to the favorable outcome. This case highlights the need for further research and guideline refinement to optimize the management of inflammatory extravascular leakage.
Factors associated with homogenization management of outpatient services in multi-campus hospitals: a cross-sectional study based on Structural Equation Model
Authors: Wang Huilin , Wang Hao , Fang Hongjun , Guan Sinan , Ge Hourui , Yang Hongyan , Li Jing
Published: February 2025

Background: The multi-campus hospitals have become increasingly prevalent in China over the past few decades, however, how to improve the quality of service and better develop the multi-campus hospitals remain insufficiently understood in the literature. Patient satisfaction is an important indicator of the measurement of service quality. This study aimed to analyze the status of patient satisfaction and its key influencing factors, in order to provide relevant reference on the homogeneous management of service and differentiated strategies aiming at consistent quality in two campuses of a tertiary hospital in Beijing.
Methods: A total of 28155 surveys of outpatients who was willing to be investigated and had not been diagnosed with infectious diseases or in a state of emergency were conducted by a cross-sectional study in Beijing, China from January to April 2024. We use a 5-point likert scale with the choices of 1 (very dissatisfied), 2 (dissatisfied), 3 (Normal), 4 (satisfied), and 5 (very satisfied) to measure patient satisfaction. Statistical description, simple and multivariate logistic regression analysis were employed to analyze patient satisfaction and its associated factors. Additionally, the correlation behind the key influencing factors are revealed by the structural equation model.
Results: Results of this study showed that the waiting time, responsiveness of patientneeds, doctors’ diagnosis, advice on treatment plan, assistive medical technology, and attitude of doctors are important influencing factors on satisfaction in both campuses. Outpatient environment and hygiene situation of the toilet had a significant effect on the central campus, while guidepost, the service group and patients aged 0-44 are important to explain the differences in the new hospital campus.
Conclusion: For the management of multi-campushospitals, more attention should be paid to the waiting time, responsiveness of patientneeds, doctors’ diagnosis, advice on treatment plan, assistive medical technology service, and attitude of doctors in both campuses. In addition, hospital managers should focus on the service group as well as the initial settings in the new campus, while considering the substantial investment in infrastructure in the central campus.
Personalized approach to the treatment of rectal fistulas
Authors:   Samara State Medical University, E. Katorkin Sergei , V. Yarovenko Galina ,   Samara State Medical University, E. Lisin Oleg ,   Samara State Medical University, V. Zhuravlev Andrey ,   Clinic of hospital surgery, chief proctologist of the Ministry of Health of the Samara region, Samara State Medical University, V. Shestakov Evgeniy ,   Clinic of hospital surgery, Samara State Medical University, V. Arustamyan Avetik ,   Clinic of hospital surgery, Samara State Medical University
Published: February 2025

Background. Rectal fistula is a common anorectal disease of a benign nature, which is a pathological canal between the perianal skin and the rectum. Treatment of rectal fistulas is only possible through surgery. The type of surgical intervention depends on the type of fistula, its topography relative to the fibers of the anal sphincters, length, as well as additional complicating factors such as the presence of scar tissue in the anal canal, branched fistulous tracts and purulent cavities. Materials and methods. In the scientific literature one can find many methods of surgical treatment of complex rectal fistulas, but the statistical results are disappointing - relapses of the disease reach 90%, and postoperative insufficiency of the anal sphincter - 50%. Results and conclusions. This article presents a clinical case of the successful use of a combination of new methods of surgical treatment of a pararectal fistula, and also reflects the dynamics of postoperative observation of the patient for 12 months. The demonstrated combined method of surgical treatment of a patient with a complex high transsphincteric pararectal fistula is sphincter-preserving, and the results of surgical treatment showed its effectiveness in terms of the development of disease relapse.
Comparative analysis of ceftriaxone, cefotaxime and amikacin empirical use in secondary widespread peritonitis in the age aspect
Authors:   Ogarev Mordovia State University, A. Markosyan Sergey , P. Vlasov Aleksey ,   Ogarev Mordovia State University, A. Charyshkin Stepan ,   Ogarev Mordovia State University
Published: February 2025

Background. A significant threat to the children health is posed by widespread forms of secondary peritonitis, which account for 16.8-42.88% of cases, and the postoperative complications frequency reaches 4%. The purpose of the study was to evaluate the empirical use effecacy of ceftriaxone, cefotaxime and amikacin in different age children with secondary widespread peritonitis. Materials and methods. In 63 children (44.4%) of different age groups with secondary widespread peritonitis, the dynamics of changes in inflammatory markers before surgery and in the early postoperative period were assessed, and a bacteriological examination of the abdominal cavity contents was carried out to identify the microflora sensitivity to ceftriaxone, cefotaxime and amikacin. Results. A conducted study of children with secondary widespread peritonitis demonstrated its highest incidence at an early age. The maximum content of inflammatory markers was determined before surgery and 1 day after surgery in all patients without exception. At the same time, at younger age groups of patients, the increase in these indicators occurred to a greater extent, and their normalization was slower, that indicated a more severe course of the purulent-inflammatory process in the abdominal cavity. Bacteriological examination of the abdominal cavity contents demonstrated the most common occurrence of E. coli (38%) both as a monovalent culture and in association with other pathogenic microorganisms. The most effective antibacterial drug was amikacin (88.2%). Ceftriaxone (79.4%) and cefotaxime (82.4%) showed less antimicrobial effect. The sensitivity lack of the microorganisms association to prescribed antibiotics was the reason for the abdominal abscesses development in 2 children in the postoperative period. Conclusion. Empirical antibacterial therapy plays an important role in the treatment of secondary widespread peritonitis. The use of amikacin as a starting antibiotic promotes the most effective effect on pathogenic microflora in secondary widespread peritonitis.
The Role of Nutraceuticals in Chemoprevention and their Therapeutic Effects when Used in Combination with Synthetic Drugs
Authors: Chio Carla Di , Luca Fabiola De , Starvaggi Josè , Previti Santo , Zappalà Maria , Ettari Roberta
Published: February 2025

Recently, increasing attention has been directed toward nutraceuticals, natural
substances extracted from plants, fruits, or cereals. These compounds are well-known
for their antibacterial, anti-inflammatory, antioxidant, and antitumor properties, with the
latter being the primary focus of this review. The use of nutraceuticals, both as standalone
treatments and in combination with standard chemotherapy, has been extensively
studied through in vitro, in vivo experiments, and clinical trials for the prevention and
treatment of various types of cancer, including breast, colon, pancreatic, prostate cancers,
and leukemia. Findings from these studies emphasize the benefits of nutraceuticals
in improving patient compliance and mitigating the adverse effects of conventional
drugs. Specifically, the combination of nutraceuticals with chemotherapy allows for reduced
dosages of synthetic drugs, thereby lessening their often-severe side effects. In
this review, we explore the diverse mechanisms of action underlying the antitumor activity
of key nutraceuticals—including curcumin, resveratrol, tocotrienols, ursolic acid,
fisetin, gambogic acid, catechins, silibinin, berberine, emodin, piperine, deguelin, garcinol,
plumbagin, zerumbone, and ginger. Furthermore, we summarize the most significant
outcomes from clinical trials investigating these compounds. The clinical studies addressed
various aspects of treatment, such as efficacy, safety, maximum tolerated doses,
potential adverse effects, and patient compliance. The majority of the findings highlight
the positive impact of combining nutraceuticals with chemotherapy, demonstrating enhanced
therapeutic outcomes in anticancer treatments.
Changing User Experience of Wearable Activity Monitors Over 7 Years: Repeat Cross-Sectional Survey Study (Preprint)
Authors: Beckett Darcy , Curtis Rachel , Szeto Kimberley , Maher Carol
Published: February 2025

BACKGROUND

Lifestyle behaviors, including physical inactivity, sedentary behavior, poor sleep, and unhealthy diet, significantly impact global population health. Wearable activity trackers (WATs) have emerged as tools to enhance health behaviors; however, their effectiveness and continued use depend on their user experience.

OBJECTIVE

This study aims to explore changes in user experiences, preferences, and perceived impacts of WATs from 2016 to 2023.

METHODS

We conducted a cross-sectional online survey among an international cohort of adults (n=475, comprising 387 current and 88 former WAT users). Results were compared with a 2016 cross-sectional online survey (n=237, comprising 200 current and 37 former WAT users) using descriptive statistics and chi-square tests. The survey examined brand preference, feature usefulness, motivations, perceived health behavior change, social sharing behaviors, and technical issues.

RESULTS

In 2023, Apple (210/475, 44%) and Fitbit (101/475, 21%) were the most commonly used devices, compared with the 2016 survey where Fitbit (160/237, 68%) and Garmin devices (39/237, 17%) were most common. The median usage duration in 2023 was 18 months, significantly longer than the 7 months reported in 2016, with most users planning ongoing use. Users in both survey years reported greater improvements in physical activity than diet or sleep, despite lower improvement in physical activity in 2023 compared with 2016, contrasted with greater perceived improvements in diet and sleep. Social media sharing of WAT data notably rose to 73% (283/387) in 2023 from 35% (70/200) in 2016. However, reports of technical issues and discomfort increased, alongside a decrease in overall positive experiences. There was also a noticeable shift in discontinuation reasons, from having learned everything possible in 2016 to dissatisfaction in 2023.

CONCLUSIONS

The study highlights significant shifts in WAT usage, including extended use and evolving preferences for brands and features. The rise in social media sharing indicates a deeper integration of WATs into everyday life. However, user feedback points to a need for enhanced design and functionality despite technological progress. These findings illustrate WAT’s potential in health promotion, emphasizing the need for user-focused design in diverse populations to fully realize their benefits in enhancing health behaviors.
New Risk Associations Between Chronic Physical Illness and Mental Health Disorders revealed by Machine Learning: A Chinese Population Study (Preprint)
Authors: Liang Lizhong , Liu Tianci , Ollier William , Peng Yonghong , Lu Yao , Che Chao
Published: February 2025

UNSTRUCTURED

The mechanisms underlying the mutual relationships between chronic physical illnesses and mental health disorders, which potentially explain their association, remain unclear. Furthermore, how patterns of this comorbidity evolve over time are under-investigated significantly. Here, four Machine Learning models were used to model and analyze the intricate interplay between mental health disorders and chronic physical illnesses. This analysis facilitated an investigation of evolving longitudinal trajectories of patients' “health journeys”. We show that five categories of chronic physical illnesses exhibit a higher risk of comorbidity with mental health disorders. Further analysis of the intensity of comorbidity revealed evidence for correlations between disease combinations. The highest intensity of comorbidity strength was seen between prostate diseases and Organic Mental Disorders (RR = 2.055, Φ = 0.212). Finally, by analyzing the effects of age and gender in different patient population sub-groups, we clarified the variability of comorbidity patterns within the patient population.
IMPROVEMENT OF TRANSVERSE STABILITY OF WHEEL TRACTOR WITH MOUNTED IMPLEMENTS
Authors:   Far East State Agricultural University, Shchitov S.V. , Kuznetsov E.E. ,   Far East State Agricultural University, Krivutsa Z.F. ,   Far East State Agricultural University, Evdokimov V.G. ,   Far East State Agricultural University, Kuznetsova O.A. ,   Far East State Agricultural University, Polikutina E.S. ,   Blagoveshchensk Polytechnic College, Yakimenko A.V. ,   Far East State Agricultural University
Published: February 2025

The possibility of using energy facilities (vehicles, machines) in difficult field environments, such as big slopes, low bearing capacity of the support surface, is a priority for diversification
of agricultural production. Therefore, it is relevant to carry out research aimed at searching new ways
to increase the maneuverability and passability of vehicles working under difficult field conditions.
In order to solve the above problem, it is proposed to install a transverse stabilizer into a wheel tractor
used as a machine-tractor unit with mounted implements. in comparison with serial version, the proposed device can change the location of center of mass, and so reduces load on the weight transfer
wheels of tractor when moving along slopes and transverse slopes of fields, increase tractor anti-roll
capacity and provides safe operation modes. The performance evaluation of the wheel tractor with
the attached transverse stabilizer was carried out on the basis of a combination of design-theoretical
analysis and corresponding experimental studies when moving on slopes and transverse slopes of
fields and making comparisons with respect to the serial version. Theoretical and experimental studies
have shown that when the proposed transverse stabilizer is installed, the left wheel (wheeled mover
located upper on the slope) is loaded, which increases the transverse stability of the machine-tractor
unit. As a result of the studies carried out, it has been found that the use of the proposed device allows
increasing the transverse stability of the tractor by 18-20% compared to the serial version.b.
RETROSPECTIVE ANALYSIS OF CLASSICAL SWINE FEVER IN WILD BOARS IN THE PRIMORYE
Authors:   Primorskaya State Academy of Agriculture, Terebova S.V. , Coltun G.G. ,   Primorskaya State Academy of Agriculture, Podvalova V.V. ,   Primorskaya State Academy of Agriculture, Korotkova I.P. ,   Primorskaya State Academy of Agriculture
Published: February 2025

Classical swine fever belongs to cross-border diseases. The Primorsky Krai has been having unfavorable situation in relation to classical swine fever of wild boars since 2015. The article
presents retrospective analysis of the detection and territorial spread of the disease in the wild nature.
The studies revealed the presence of natural nidus of classical swine fever in six districts of the Primorsky Krai, which are of anthropogenic origin.
Development of academic burnout during COVID-19 pandemic: The role of perceived social support
Authors: Malcic Borka , Maric-Jurisin Stanislava , Bekic Simona , Gajic Olivera
Published: February 2025

University life plays a crucial role in providing social support to its
academic community, whilst also serving as a protective factor for
developing mental health issues. However, the advent of the Coronavirus in
2019 left substantial changes in the education system. In this article, the
authors? main goal was to examine the correlation of perceived social
support and academic burnout levels during the COVID-19 pandemic. The
research was conducted online, using the MBI-SS and the Scale for Assessing
the Degree of Social Support. Based on survey data of 528 students from 11
different faculties from the University of Novi Sad, the findings
demonstrate students? levels of academic burnout and perceived social
support, as well as their relationship with demographic characteristics such
as gender, level of study, academic achievement, and model of study payment.
The findings revealed a negative correlation between perceived social
support and academic burnout. The authors underscore the importance of
academic burnout prevention during crisis periods like the pandemic, as well
as university support in providing adequate burnout rehabilitation programs.
Kids' Environment and Health Cohort: Database Protocol
Authors: Akaraci Selin , Macfarlane Alison , Rammah Amal , Courtin Emilie , Lewis Esther , Miller Faith , Powell-Bavester Jason , Mitchell Jessica , Cruz Joana , Lilliman Matthew , Shoari Niloofar , Hajna Samantha , Cummins Steven , Adedire Tolu , Nafilyan Vahe , Hardelid Pia
Published: February 2025

IntroductionEnvironmental exposures are known to affect the health and well-being of populations throughout the life course. Children are particularly susceptible to environmental impacts on educational and health outcomes as they spend more time in their local environments compared to adults. In England, no national, longitudinal dataset linking information about the physical and social environment in and around homes and schools to children's health and education outcomes currently exists. This limits our understanding of how environments might impact the health and well-being of children as they grow up.
ObjectiveTo establish the Kids' Environment and Health Cohort, a research-ready, de-identified and annually updated national birth cohort of all children born in England from 2006 onwards.
MethodsThe Kids' Environment and Health Cohort will link birth and mortality records, health and educational attainment datasets, to maternal health (up to 12 months prior to their child's birth), and environmental data for all children born in England from 2006 -- approximately 11 million children at first build. A subset of children born between 2010 and 2012, and between 2020 and 2022 will be linked to their mothers' 2011 or 2021 Census records, respectively. The cohort database will be held in, and accessed via, a trusted research environment (TRE) at the Office for National Statistics (ONS). All geographical identifiers in the cohort, allowing for linkage to further environmental data, will be securely held by the ONS, separately to the main cohort, and will be encrypted before being shared with researchers.
ConclusionThe Kids' Environment and Health Cohort will, for the first time, link administrative health and education data to longitudinal environmental exposures for children at national level in England. It will serve as a data resource to support research about the health and well-being of children via improved home and school environments.
Integrált ütemes menetrend a Dunakanyartól a Kékestetőig
Authors: Borza Viktor , Vincze Béla György
Published: February 2025

Magyarország autóbusz-közlekedési rendszere kitűnő területi lefedettséggel rendelkezik, ugyanakkor az utazások időbeli rugalmasságot egyelőre csak a legnagyobb forgalmú viszonylatokon biztosítanak az utasok számára. Bár ezen a téren is folyamatos a fejlődés, ha a közvetlen (átszállásmentes) eljutások elsődleges prioritásából továbbra sem engedünk, akkor nem fogjuk tudni aránytalan forrásbevonás nélkül a kis- és közepes települések számára is biztosítani az egyéni közlekedéssel versenyképes időbeli lefedettséget (két-, fél-, illetve órás ütemes eljutási lehetőségek hajnaltól késő estig).
A 100a vasútvonal üzemeltetési és szolgáltatásfejlesztési tapasztalatai
Authors: Csaba Zsolt Márton
Published: February 2025

A 100a (Budapest-Cegléd-Szolnok) vasútvonal Magyarországon utasforgalom szempontjából a legforgalmasabb. A vasútvonal 2018 és 2022 között számos probléma elé állította a pályahálózat-üzemeltető és személyszállítási szolgáltató vasútvállalatokat.
Gyalogos átkelés és elsőbbségadás-szabályozás módszerei és továbbfejlesztési lehetőségeinek vizsgálata Vissim forgalomszimulációs programban
Authors: Szigeti Szilárd , Aba Attila , Földes Dávid
Published: February 2025

Cél a Vissim forgalomszimulációs szoftver működésének vizsgálata gyalogátkelőhely környezetében. Elsődleges fókuszterület az elsőbbségadás szabályozási módok működési elvének bemutatása, összevetésük, hiányosságaik feltárása, valamint a továbbfejlesztési lehetőségek bemutatása.