bluuebunny/crossref_metadata_2025 huggingface dataset:
Medicine balls training in the sequence of complex handball training versus only handball training: effects on physical fitness in pre-adolescence female handball players
Authors: Chukhlantseva Natalia
Published: December 2023

Introduction: The inclusion of the training process of pre-adolescent female athletes with additional means helps to optimize exercise influences. The study aims to estimate the influence of a 16-week program of handball training with medicine balls in comparison with a program of handball training on the physical and special training of beginner handball players. Methods: Female athletes were randomly divided into an experimental (n = 30; 11.23 ±0.41 years) and a control (n = 32; 10.99 ± 0.4 years) group. Training sessions of both groups were conducted according to the existing curriculum, but the experimental group replaced part of the usual regimen by training with medicine balls once a week. Results: Both groups improved, but more markedly in the experimental group than in the control group in the increase of leg explosive power (Δ% = 7.73, p < 0.05, d = 0.67), trunk muscle strength (Δ% = 16.9, p < 0.05, d = 0.88) and ball handling level indicators: dribbling the ball (δ% = 13.41, p < 0.05, d = 1.07), throwing the handball ball with one hand (Δ% = 28.6, p < 0.05, d = 1.6). Conclusions: A program of workouts with medicine balls enables the improvement of important components of physical performance. Inclusion of the training process of pre-adolescent female athletes with additional means helps to optimize exercise influences.
Análisis de riesgos posturales en trabajadores del lobby bar de una instalación hotelera
Authors: Contreras-Rodriguez Marcia , Avila-Sánchez Pablo Jesús , Acosta-Prieto Juan Lázaro
Published: December 2023

La prevención de riesgos laborales garantiza que los trabajadores realicen un trabajo eficiente, seguro y saludable. Existen diferentes puestos de trabajo en el sector hotelero dentro de la industria del turismo, los cuales, de manera conjunta, brindan un servicio de calidad a los clientes que accedan al mismo. La coctelería, o el servicio de bebidas, son altamente demandados por los clientes. El personal que labora brindando este servicio pasa la mayor parte de la jornada laboral de pie, lo que pudiese ocasionar trastornos músculo-esqueléticos. La presente investigación tiene como objetivo realizar un análisis de riesgos posturales a los trabajadores que ocupan el puesto de cantinero en el Lobby Bar de una instalación hotelera. Se utiliza para identificar zonas corporales afectadas el Diagrama de Corlett y Bishop y como método de evaluación postural el Rapid Entire Body Assessment (REBA) y el empleo del software Kinovea para determinar los ángulos corporales. Se obtiene como resultado que los trabajadores del área del Lobby Bar están expuestos a un nivel de riesgo alto por adoptar posturas repetitivas y por largos períodos de tiempo con puntuaciones REBA de 9, presentando mayor incidencia en brazos y pie. Los cantineros a partir del alto riesgo en la evaluación postural obtenida por REBA presentan una elevada probabilidad de desarrollar algún trastorno músculo-esquelético, por tanto, es necesaria una pronta intervención.
Examining the effectiveness of Guava leaf extract in mitigating corrosion of aluminium in potassium hydroxide solution
Authors: Benson Chinweuba Udeh  , Monday Omotioma  , Sunday Ejiofor Ede
Published: December 2023

This study is on the effectiveness of guava leaf extract in mitigating corrosion of aluminium in potassium hydroxide solution. Functional groups of the extract were revealed using Fourier transform infrared spectroscopy. In addition, qualitative and quantitative analyses of the extract were carried out to ascertain the level of the phytochemicals. Effects of process variables on the effectiveness of guava leaf extract as corrosion inhibitor were determined. Then, modeling of the experimental data of inhibition efficiency of the guava leaf extract was carried using response surface methodology. In the process, modeling of the inhibition efficiency was actualized using design expert software version 11. Analysis of variance and diagnostic analysis of the model on interactive effects of inhibitor concentration, temperature and time on the inhibition efficiency were examined. Analysis of the results showed that the main functional groups of guava leaf are O-H stretch, C-H stretch, N-H bend, CH3C-H bend, C-O stretch and C-H bend. Alkaloid was found to be highly concentrated in the extract; 223.71 ±0.12 mg/100g. Tannins, flavonoids, phytates and saponins were present at moderate (concentrated) levels. Weight loss, corrosion rate, inhibition efficiency and degree of surface coverage were influenced by the inhibitor concentration, temperature and time. Quadratic model adequately described the relationship between inhibition efficiency and process variables. The predicted R² of 0.9311 is in reasonable agreement with the adjusted R² of 0.9867. Guava exhibited high inhibition efficiency. Hence, it can be used to inhibit corrosion of Al in KOH solution.
Correlation between HbA1c levels and left ventricular function in children with Type 1 Diabetes Mellitus
Authors: Desmiyati Natalia Adoe  , Ni Putu Veny Kartika Yantie  , Made Sukmawati  , Ida Bagus Subanada  , Made Gede Dwi Lingga Utama  , I Made Arimbawa
Published: December 2023

Background: Diabetic cardiomyopathy is one of the macrovascular complications in type 1 diabetes mellitus (T1DM). Left ventricular dysfunction primarily reflects diastolic dysfunction which is early sign of diabetic cardiomyopathy. Improved glycemic control can delay the onset and progression of this complication. An important indicator of long-term glycemic control is glycosylated hemoglobin (HbA1c). Objective: The aim of this study is to evaluate the correlation between HbA1c levels with left ventricular diastolic function in children with T1DM. Methods: This study was an observational study with cross-sectional design in children aged 1 month-18 years with T1DM, at Prof Dr. I.G.N.G. Ngoerah Hospital, Denpasar from November 2019–September 2021, using consecutive sampling. Glycosylated hemoglobin (HbA1c) was meassured by blood samping and LV function was assessed by using tissue Doppler imaging (TDI). Statistical analysis was done by Pearson and Spearman correlation test. A p-values of <0.05 was considered statistically significant. Results: A total of 36 subjects were recruited in this study. There was a low positive correlation between HbA1c levels with E/e’ ratio (r=0.284, p=0.047), and MPI (r=0.358, p=0.020). After adjusting body mass index and duration of T1DM as confounding variables, we found a low positive correlation between HbA1c levels and E/e’ ratio (r=0.325, p=0.030), MPI (r = 0.390, p=0.020). Conclusion: HbA1C has a positive correlation with left ventricular diastolic function in children with T1DM.
Study to improve the physical-mechanical behavior of corncob particleboard by adding recycled low-density polyethylene (LDPE)
Authors: Ayarema AFIO  , Sinko BANAKINAO  , Yawo Natê AGBETOSSOU  , Soviwadan DROVOU  , A. Komlan KASSEGNE
Published: December 2023

The aim of this work is to improve the behavior of particleboard made from corn cobs, an abundant resource resulting from the valorization of Togolese agricultural and agro-industrial residues. The methodology adopted consists in manufacturing particleboard by grinding collected corn cobs into flour. The particles obtained will be used to manufacture different types of panels by varying the input parameter for panel production, i.e. the reclaimed low-density polyethylene (LDPE) content, in order to improve the performance of conventional particleboard. The LDPE content was varied from 5% to 20% in 5% increments. The next phase of the work involved determining the physical and mechanical characteristics of the panels produced by subjecting the cut samples to various tests, such as: · Swelling test in water to obtain swelling thickness and water absorption rate ; · Three-point bending test to determine modulus of elasticity (e) and maximum bending moment leading to rupture · Traction test to characterize the modulus of maximum stress at break σr determined as a function of particle size and ldpe content. A total sample of 180 particleboards measuring 300 x 300 x 5 mm was tested. The densities obtained enable the corncob particleboards produced to be classified as high and medium density panels (m-1, s ; m-2, s) according to the american standard ansi a208.1-2009 [7][8]. As far as swelling is concerned, the particleboards have a low resistance to water, and can therefore only be used in dry interior environments, requiring protection against moisture. The thresholds set by ansi a208.1-2009 for modulus of elasticity e and modulus of rupture have largely been reached, and the results increase with increasing ldpe content for smaller grain sizes.
Phytochemical and antibacterial potential of lime (Citrus aurantifolia) and lemon (Citrus limon) juices as bioactivators of charcoal
Authors: Ezinne Oluoma Ozoani  , Uzoamaka Ogechi George-Okafor
Published: December 2023

Citrus juices are widely consumed because of their many health benefits and antimicrobial properties. Biological activators are preferred to the conventional chemical activators for safety and less health hazards thus the need to search for available indigenous biological materials for charcoal activation. Hence, the study on the potentials of lime (Citrus aurantifolia) and lemon (Citrus limon) juices as biological activators for charcoal. Freshly harvested lime and lemon juice were extracted using juice extractor and sterilized through filtration with membrane filter (0.45µl pore size). The phytochemical of the juices was determined and results revealed the presence of (carbohydrates, flavonoids, cardiac glycosides, saponins, terpenoids, ketose(fructose) and reducing sugars). The lime and lemon juices were subjected to antibacterial screening by agar well diffusion method against the test bacterial isolates (Staphylococcus aureus and Salmonella enterica subsp. entericaserovar) at 75%, 50%,25% and 12.5% concentrations respectively. The lime and lemon juice inhibition effects decreased with decrease in concentration. However, lime juice demonstrated higher inhibition across all concentrations in both test organisms with zones of inhibition (12-30mm) in Salmonella and (10-28 mm) in S. aureus while lemon juice demonstrated a low antibacterial activity across the different concentrations with zones of inhibition ranging from (12-17mm) in Salmonella and (9-24mm) in S. aureus. The phytochemical and antibacterial activities of lime and lemon juice revealed their potential utilization as bio activators.
Mixed reality in U.S. retail: A review: Analyzing the immersive shopping experiences, customer engagement, and potential economic implications
Authors: Prisca Ugomma Uwaoma  , Emmanuel Osamuyimen Eboigbe  , Nsisong Louis Eyo-Udo  , Amina Catherine Ijiga  , Simon Kaggwa  , Andrew Ifesinachi Daraojimba
Published: December 2023

This study aims to explore the transformative impact of Mixed Reality (MR) technologies in the U.S. retail sector. It focuses on analyzing how MR reshapes shopping experiences, enhances customer engagement, and influences the economic landscape of retail. The methodology encompasses a comprehensive literature review, utilizing academic journals, conference proceedings, and industry reports. The search strategy involved keyword searches and manual screening, with inclusion and exclusion criteria set to filter relevant literature. The selection criteria prioritized recent studies to capture the latest trends in MR technology. The key findings reveal that MR technologies have evolved significantly, offering immersive and interactive shopping experiences that revolutionize customer engagement and satisfaction. The economic implications of MR in retail are profound, indicating substantial market growth and financial opportunities for retailers. However, the adoption of MR also presents challenges, including the need for integration into existing retail models and the development of user-friendly interfaces. The study also highlights the importance of regulatory frameworks and standardization in the successful implementation of MR technologies in retail. In conclusion, MR technologies hold great potential for the retail sector, offering innovative ways to engage customers and enhance their shopping experiences. However, realizing these opportunities requires overcoming various challenges, including adapting financial strategies and addressing infrastructure needs. As MR continues to evolve, it is poised to play a pivotal role in shaping the future of the retail sector. The study underscores the need for ongoing research to fully understand and leverage the potential of MR in retail.
Ideological discursive structures in political speeches: A critical discourse analysis of selected speeches of Mr. John Dramani Mahama
Authors: Aikins Addae  , Godwin Kusi Danquah  , Alhassan Hamidu  , Kofi Adjei-Yeboah
Published: December 2023

Language continues to be a very important tool in politics. This is because, in political communication, politicians usually employ linguistic structures that have ideological implications so that they will be able to win the trust, confidence and ratification of their audiences. Towards this end, this study looks at the role of language in creating ideology and ideological discursive structures in political speeches. The study specifically explores the linguistic expressions that carry the ideologies of President John Dramani Mahama. The study uses the qualitative research approach and adopts critical discourse analysis (CDA) as the design. The purposive sampling was employed and the theoretical lens of Fairclough and van Dijk’s critical discourse analysis framework was used to analyse the data. The study discovered that Mahama conceals his ideologies in his speeches and that he employs discursive structures such as evidentiality, pronouns, rhetorical questions, metaphors and modal verbs. The study further revealed that the discursive structures also produce and sustain power and unequal power relations between Mahama and his audience. The study afforded much evidence to conclude that politics is a game that can be successfully played through a skillful employment of language.
Drone agrotechnology’s for cotton (Gossypium hirsutum L.) pest and diseases management in Western of Burkina Faso
Authors: Adama ZONGO  , Oumar BADINI  , Emile KABORE  , Adama TRAORE  , Sylvestre SAWADOGO  , Mahamadou SAWADOGO
Published: December 2023

Drone technologies, also known as "unmanned aerial vehicles" (UAVs) or "unmanned aerial systems" (UAS), have a wide range of applications, including mapping, land-use planning, crop/infrastructure damage assessment, fertilizer spraying and precision crop protection. However, its use is still very limited in the agricultural sector in Africa in general and in Burkina Faso in particular. This study was initiated to explore the potential of UAVs for optimizing cotton yields through monitoring and phytosanitary efficiency. To this end, phytosanitary treatments and monitoring of vegetation status using multispectral drone imagery were carried out on cotton. The experimental sample consisted of four (04) cotton fields in four (04) locations. Phytosanitary treatments and aerial photography were respectively carried out using a DJI AGRAS T16 spray drone and a DJI Phantom 4 Multispectral drone. Phytosanitary treatment with DJI AGRAS T16 drone resulted in savings of 32.41% in treatment duration, 23.58% in water, 1% in pesticides and 10.5% in labor compared with manual spraying, but did not have a positive impact on boll yields due to jassid populations attack. The RGB and NDVI vegetation indices generated by photogrammetric processing of multispectral images acquired by drone enabled us to perceive phytosanitary state of cotton plants during their development cycle. Information provided by these vegetation indices and by this study in general can be used to improve the efficiency of phytosanitary treatments against cotton pests and diseases.
Spontaneous penile abscess: A case report with literature review
Authors: Mohamed Bakhri  , Jaafar BENJAAFAR MARRAKCHI  , Mouayad Jadouane  , Mustapha AHSAINI  , Soufiane MELLAS  , Jalal Eddine EL AMMARI  , Mohammed Fadl TAZI  , Mohammed Jamal EL FASSI  , Moulay Hassan FARIH
Published: December 2023

Penile abscess is an unusual pathology in the practice of urologists, given the rarity of cases. It can occur spontaneously or be secondary to trauma, injection, or endourethral procedures. Diagnostic confirmation is achieved through imaging. Treatment involves surgical or radiological drainage, depending on the size and location of the abscess, along with antibiotic therapy. Postoperative complications may include erectile dysfunction and penile deviation, necessitating subsequent surgical repairs.
Bacterial ecology related to healthcare in a Moroccan intensive care unit: A prospective analysis of 53 cases
Authors: Fatima Bouyarmane  , Imad Daoudi  , Nawfal Houari  , Soumaya Touzani  , Abderrahim El Bouazzaoui  , Brahim Boukatta  , Nabil Kanjaa
Published: December 2023

Introduction: This study aims to determine the incidence of healthcare-related infections in our structure, identify the different types of healthcare-related infections in order of frequency, and understand the bacterial ecology. Materials and methods: We conducted a prospective observational, descriptive study, which included all patients over 16 years of age who were hospitalized in the Intensive Care Unit (ICU) A4 of the Hassan II University Hospital of Fez. The study was performed over a period of 12 months, from May 2021 to May 2022. Patients hospitalized in the ward during this period were all monitored throughout their stay. The study included those who developed a healthcare-related infection, regardless of the site of the infection. We excluded all patients who did not present with a healthcare-related infection and those who were discharged from intensive care or died within the first 48 hours. Results: Seven hundred and sixty-four patients were admitted to ICU A4 during the study period from May 2021 to May 2022. Out of these, 53 patients developed healthcare-related infections, resulting in an incidence rate of 6.9%. The average age of our patients was 47.42 years, with a significant male predominance. A total of 120 healthcare-related infections were documented during this study period. Bacteremia accounted for the highest percentage at 64.2%, followed by infections related to catheters and pneumopathies acquired under mechanical ventilation, both at 60.4%. Additionally, surgical site infections comprised 22.6%, while urinary tract infections accounted for 18.9%. The average time of infection onset associated with care, compared to hospitalization, was 5.85 days. The evolution was favorable in 13 (24.5%) cases, and unfortunately, there was a significant mortality rate of 40 (75.5%) patients. The isolated germs were mainly Acinetobacter baumannii, with a rate of 88 (61.11%) cases, followed by enterobacteria, which made up 44 (30.55%) cases. In third place comes Pseudomonas aeruginosa with a rate of 13 (9.02%), followed by enterococci with a rate of 10 (6.94%), and Staphylococcus with a rate of eight (5.55%). four (2.77%). Conclusion: Healthcare-related infections are frequent in ICUs and can be serious. The severity of these infections is due to both the infection itself and the compromised immune defense mechanisms of the patient, which reflect their overall health condition. Moreover, prevention is still the best weapon.
Optimization of the various strengths of concrete made from two different types of coarse aggregates using Scheffe’s model
Authors: Ozor Chiwenite Geoffrey  , Celestine Odenigbo  , P.N. Onuamah
Published: December 2023

This research work on the Optimization of the Various Strengths of Concrete Made from Two Different Types of Coarse Aggregates using scheffe’s model. The coarse aggregates (crushed and uncrushed) was obtained from Nkalagu, Ebonyi State. Cement was bought from Kenyatta market, sharp river sand was collected from Nyama River here in Enugu State and water used was gotten from Enugu state water corporation. The practical tests were conducted at Enugu State University of Science and Technology (ESUT) Laboratory, Enugu. Tests that were carried out were series of tests, specific gravity, casting and crushing of the cubes and compressive strength tests were carried out. Natural sand with fineness modulus of 2.27 was used as fine aggregate. Ordinary Portland cement was used as binding material. Mix proportions 1:1:2 with crushed and uncrushed aggregate types were used in the research. The water/cement ratio adopted for the study was 0.59 throughout the experiment. The target mean strength at 28days was 25N/mm2. Twelve concrete cubes (150mm x 150mm x 150mm) were cast for each coarse aggregate type of which three were crushed at each maturing age namely 8, 14, 21, and 28 days from each mix, 12 cubes were cast for each of the two types of coarse aggregate, making a total number of 24 cubes. The concrete cubes are to be casted in laboratory and tested in hydraulic compression testing machine.
Psychiatric aspect of persistent somatic symptoms after COVID-19: A systematic review
Authors: Adwin Setyanagara  , Zuhrotun Ulya  , Dearisa Surya Yudhantara  , Frilya Rachma Putri
Published: December 2023

Persistent somatic symptoms (PSS) represent a prevalent phenomenon frequently co-occurring with mental disorders and a higher incidence of depression and anxiety. There is no clear etiopathophysiology of PSS, which makes the diagnosis process difficult. The prevalence of PSS has been observed to rise in response to the COVID-19 pandemic, with 72.5% of post-COVID-19 patients experiencing persistent symptoms. This condition is predicted to become a public health problem in the future, and researchers need to conduct research on the relationship between the post-COVID-19 condition and PSS to provide comprehensive treatment suggestions. In this study, we tried to investigate and summarize various studies related to PSS after COVID-19, which are discussed from a psychiatric perspective. Three databases, including PubMed, ScienceDirect, and Google Scholar, were used to conduct a systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria. The current search was performed from July to August 2023 by combining the keywords. 21 articles were analyzed descriptively to help describe and summarize the data constructively. The results showed that several studies investigated the prevalence of this case, and all studies that included prevalence information showed that majority of those who recovered from COVID-19 have reported experiencing PSS. Thus, persistent somatic symptoms after COVID-19 are associated with psychiatric problems; this condition requires a multidisciplinary approach to provide appropriate management.
Developing learning media of statistics stake props on mean, median, and mode materials for eighth graders at SMP Negeri 9 Gorontalo, Indonesia
Authors: Erwin Asnawi  , Ismail Djakaria  , Majid
Published: December 2023

This R&D (Research and Development) research explores the development of the learning media of statistics props on mean, median, and mode materials for eighth graders at SMP Negeri 9 Gorontalo. It refers to the Four-D development model, covering four stages, i.e., Define, Design, Develop, and Disseminate. As regards validation, material and media experts gave scores of 93.8% and 93%, respectively, in the Very Valid category. Learning media of statistics stake props on mean, median, and mode materials were very practical to be used by students, as demonstrated by teacher responses, at a percentage of 100%. The learning media were also considered effective, based on student responses and learning tests, which came with an increase in scores. Before using the learning media, 16 students scored 64.4 on average (below Minimum Completeness Criteria) in the Poor category, and 16 others scored 72.3 (above Minimum Completeness Criteria) in the Acceptable category. After using the learning media, eight students scored 74.38 on average at the Acceptable criteria, 20 scored 84.67 on average at the Good criteria, and four scored 94.38 on average at the Excellent criteria. Based on student response questionnaires, the percentage of using learning media of statistics stake props on mean, median, and mode materials achieved more than 89.71%, indicating very positive student responses. Grounded on the results, we could infer that learning media of statistics stake props on mean, median, and mode materials were valid, effective, and reliable to use.
Development and characterization of Tinospora cordifolia extract-loaded SLNs for the treatment of autoimmune hepatitis
Authors: Savisa Yadav  , Pooja Rani  , Kumari Shanno  , Raman Kumari  , Shamim  , Tarmeen Ali  , Nitin Chandrakant Mohire  , Gita Nitin Mohire  , Ravindra Bhimraj Laware
Published: December 2023

Solid Lipid Nanoparticles (SLNs) have emerged as promising drug delivery systems with the potential to enhance the therapeutic efficacy of bioactive compounds. In this study, T. Cordifolia extract-loaded SLNs were developed and characterized for their application in the treatment of autoimmune hepatitis. T. Cordifolia, known for its immunomodulatory and anti-inflammatory properties, was chosen as the active ingredient. The formulations were systematically evaluated for drug-excipient compatibility, particle size, zeta potential, drug loading efficiency, drug release kinetics, encapsulation efficiency, in-vitro release, and stability. The results indicated "No Change" in drug-excipient compatibility, ensuring the formulation's stability. The SLNs exhibited nanoscale particle sizes (159.30 nm to 172.12 nm) with narrow size distributions, facilitating consistent drug delivery. Negative zeta potentials (-28.28 mV to -35.44 mV) indicated colloidal stability. High drug loading efficiencies (up to 32.23%) and controlled drug release kinetics were observed, suggesting the potential for sustained and targeted drug delivery. Encapsulation efficiencies of up to 83.41% highlighted efficient drug loading within the SLNs. In-vitro release studies revealed that SLN2 and SLN4 exhibited superior drug release profiles compared to other formulations. These findings indicate the potential of these formulations for controlled drug delivery. In-vivo efficacy studies in murine models of autoimmune hepatitis are recommended to assess the therapeutic benefits of T. Cordifolia extract-loaded SLNs. Additionally, stability studies demonstrated the maintenance of critical parameters, such as particle size, zeta potential, and drug loading efficiency, under different storage conditions.
Thermochemistry of alkalization and etherification of cellulose
Authors: Michael Ioelovich
Published: December 2023

In this research, the process of alkalization of cotton cellulose with solutions of sodium hydroxide of different concentrations has been studied. It was found that the enthalpy of cellulose alkalization is exothermic. Moreover, the exothermic enthalpy value of cellulose alkalization with 30-40% NaOH solutions is higher than with 16-20% alkalis. Thus, the cellulose treatment with 30-40% alkalis provides the formation of more reactive alkali cellulose. In addition, the determination of the formation enthalpy of alkali celluloses showed that this thermochemical characteristic is also exothermic, and therefore, the process of cellulose alkalization is energetically favorable. It is most likely that cellulose alkalization is a physicochemical process of forming a molecular adduct of hydrated hydroxide ions with cellulose. A study of the methylation reaction of alkali cellulose with methyl chloride to a degree of substitution of 1.3-1.8 showed that the enthalpy of this reaction is quite exothermic. This means that methylation reaction is energetically advantageous, and obtaining methylcellulose with a higher degree of substitution is preferable.
The potential use of recombinant immunotoxin and BCL-2 inhibitors for leukemic stem cell elimination
Authors: Diondra Eka Rizkiawan
Published: December 2023

Leukemia is a type of hematological malignancy caused by the dysfunctional proliferation of leukocyte cells. According to the Global Burden of Disease 2019 report, there were over 643,579 new cases of leukemia cancer worldwide in 2020, killing 334,592 people. Chemotherapy, an important part of the treatment of leukemia, not only harm cancer cells but also harm healthy cells, which can lead to negative side effects. This article examines the possibility for cutting-edge therapy using targeted recombinant immunotoxins and BCL-2 inhibitors as targeted therapy against leukemic stem cells. Recombinant immunotoxin is a protein-based therapeutic agent composed of toxins combined with specific antibodies or other molecules such as growth factors, cytokines, or toxins. Diphtheria Toxin (DT) is the most commonly used toxin because it is easily expressed, making the toxin easier to take. The toxin kills cancer cells by inhibiting enzymatic cell protein synthesis. While immunotoxins enhance therapeutic outcomes by targeting leukemia stem cells, their efficacy can be compromised in certain patients due to apoptosis resistance mediated by proteins like BCL-2. The presence of anti-apoptotic protein BCL-2 enables cell survival even after exposure to immunotoxins. Consequently, combining recombinant immunotoxins and BCL-2 inhibitors holds promise for eradicating LSC and preventing relapse.
Risk of Bell's Palsy after COVID-19 vaccination
Authors: Pratiwi Soesilawati  , Melza Nur Ramadhania  , Annisa Anggie Tjahyaning Negri  , Yuliati
Published: December 2023

At the close of 2019, a global health crisis known as COVID-19, or coronavirus (2019-nCoV), broke out. Vaccination is used as a means of prevention. The COVID-19 vaccines may be categorized into four groups: viral vector, entire virus, subunit protein, and nucleic vaccines. Upon evaluating the advantages of vaccinations, it becomes evident that there are adverse side effects that may develop. Bell's palsy is regarded as a significant adverse reaction after immunization. This observational essay aims to consolidate knowledge about the SARS-CoV-2 infection and its association with the risk of Bell's palsy after COVID-19 vaccination.
Evaluation of Teaching Methods and Technical Opportunities for the Distance Education Process of Veterinary Faculty Students in Turkey during the COVID -19 Pandemic
Authors: ASLIM Gökhan , TEKİNDAL Mustafa Agah , YİĞİT Ali , MENTEŞ GÜRLER Ayşe , SANAL Şule
Published: December 2023

Covid-19 has caused the death of nearly 5 million people and severe problems in education and all areas of life. When the first case was detected in Turkey, education was suspended in all educational institutions on March 16, 2020. It was decided to continue education in the digital environment through distance and open education for the 2019-2020 spring academic semester. The survey study aimed to evaluate the opinions and thoughts of veterinary students about the methods and technical possibilities of distance education courses. The survey was conducted with 2nd, 3rd, 4th, and 5th-year 1,599 students studying at Veterinary Faculty in Turkey who have experience in both face-to-face and distance education via “Google Docs” between December 10, 2020, and January 11, 2021. It was determined that the rate of those using their computer is 67.2%. However, the difficulties of online courses were determined by the lack of professional development (75.4%), technical problems (73.3%), accessing the Internet (56.8%), etc. Although students find the course time sufficient, courses should be supported with PDF, Word, and PowerPoint documents (78.2%). In addition to the safety concerns of distance education, students say they do not prefer it since it is an application-oriented field in veterinary medicine education and technical problems. It can be suggested that the concerns of students, such as professional development and professional-social interaction due to being away from school, can be eliminated with support training to be held after the pandemic.
Analisis Sistem Kompensasi (Studi Kasus PT XYZ)
Authors: Safira Hasan Elsya , Christian Wiradendi Wolor  , Marsofiyati
Published: December 2023

Perusahaan harus mampu menciptakan kondisi yang mendorong dan memungkinkan pembangunan dan perbaikan kemampuan dan keterampilan yang ada untuk dilakukan secara optimal. Satu cara sebuah perusahaan dapat mencapai hal ini adalah dengan memberikan kompensasi kepada semua karyawannya. Kompensasi adalah segala sesuatu yang diberikan kepada karyawan sebagai penyelesaian pada pekerjaan mereka. Dengan kompensasi yang baik, bentuk pembayaran, manfaat, dan insentif yang baik dapat memotivasi karyawan untuk meningkatkan produktivitas mereka di tempat kerja dan dilakukan secara optimal. Penelitian ini menggunakan pendekatan deskriptif kualitatif yang menggambarkan dan menganalisis problem-problem yang ditemukan. Penelitian kualitatif didasarkan pada data primer dan sekunder. Data utama dalam penelitian ini diperoleh melalui pengamatan langsung dan tidak langsung seperti penelitian, wawancara, dan dokumentasi, sementara data sekunder diperoleh melalui buku-buku yang berhubungan dengan penelitian, penelitian sebelumnya, dan artikel. Tujuan studi ini adalah untuk mengetahui dan menjelaskan sistem kompensasi yang digunakan di XYZ mencakup aplikasi kompensasi langsung dan aplikasi kompensasi tidak langsung. Hasil studi ini mungkin diketahui bahwa PT XYZ telah memberikan kompensasi langsung dan tidak langsung dan telah menerapkan kompensasi tidak langsung, tetapi belum diberikan pada waktunya dan para karyawan belum menerima kompensasi langsung maupun tidak langsung. Yang dapat dibuktikan dengan wawancara dan riset yang dilakukan.
Deprem Sonrası Açık Yeşil Alan Kullanım Olanaklarının Kilis Kentsel Sit Alanında İrdelenmesi
Authors: TAŞÇIOĞLU Saliha
Published: December 2023

Kentlerin temel çekirdeği konumundaki Kentsel Sit alanları, şehrin ana karakterini yansıtan özelliklere sahiptir. Yeşil alanlar ise, kentlerin estetik değerini arttırmanın yanısıra, yaşam kalitesine katkı sunmaktadır. Bu katkı kullanıcılar üzerinde olumlu yönlü ruhsal ve psikolojik desteği içermektedir. Kilis Kentsel Sit Alanı 6 Şubat 2023’de ülkemizde gerçekleşen Kahramanmaraş merkezli depremde, birçok tarihi yapının etkilendiği ve hasarın oluştuğu alandır. Çalışmada öncelikle Kentsel Sit alanı içerisinde yer alan ve imar planında park olarak belirlenen 8 adet alan belirlenmiştir. Sonraki aşamada ise, bu parkların kullanımı irdelenmiş, bitki türleri ve mahallelere dair kişi başı park kullanım alanı hesaplanmıştır. Çalışma alanında en büyük yeşil alan miktarı ve sert zemin alanı İslambey Parkı’nda, en fazla bitki çeşitliliği ise Ayşecik Çay Bahçesi’nde tespit edilmiştir. Çalışmada, bu alanların planlanma aşamasında, deprem sonrasında kullanımı destekleyici mekan kullanımı, donatı elemanları ve malzeme seçiminin önemine vurgu yapılmıştır.
WREN: A Deliberative Design Tool Supporting Systemic Change
Authors: Rose Phillippa , Betton Victoria
Published: December 2023

There is a lack of consideration of power dynamics and wider influences,
context and system in Western dominant design models
pioneered by the likes of the Hasso Plattner Institute and IDEO’s
Design Thinking frameworks. The focus on human desirability,
balanced against feasibility and viability has shifted. Over the last
decade, global events, seismic technological advances, increasingly
wicked problems and the effects of climate change have
heightened the awareness of the fragility of humanity, society
and economies.
Eliminative Design for Sustainable Futures in Service Design: Using our erasers as design tools
Authors: Havasi Zoltán
Published: December 2023

I have often pondered the crucial question that should precede
any design endeavour: Do we truly require what the design
process may yield? Would we not be wiser to judiciously employ
existing solutions? Shouldn’t we consider elimination not only as
a means, but also an end for our design? Perhaps the starting
point for our design activities should be the eradication of false
needs. This is what’s known as ‘eliminative design’.
Trayectoria de las primeras universitarias en Valladolid: de la excepción a la depuración
Authors: Gómez Cuesta Cristina , Rodríguez Serrador Sofía
Published: December 2023

Presentamos en este estudio una radiografía de las mujeres que estudian en la Universidad de Valladolid, influidas por momentos políticos diferentes. La panorámica sobre el acceso de las pioneras y las mentalidades acerca de la condición social de las mujeres de finales del xix, nos permite profundizar en lo ocurrido durante la dictadura de Primo de Rivera y, especialmente, en la Segunda República, analizando cifras y cambios. A partir de aquí, rescatamos las trayectorias de mujeres singulares no solo por llegar a la universidad, sino porver condicionadas, cuanto menos, sus aspiraciones profesionales, fruto de la depuración franquista. El análisis cuantitativo y cualitativo de las fuentes documentales custodiadas en el Archivo de la Universidad de Valladolid quiere arrojar luz sobre la evolución y condicionantes de la presencia femenina en esta universidad y reconstruir aquellas vidas marcadas por el estallido de la guerra civil y la dictadura franquista.
Una vida destrozada por la Guerra Civil española: el caso de Polonia Mateos Pérez
Authors: García Carrero Francisco Javier , Ruiz Berdún Mª Dolores
Published: December 2023

Durante la Guerra Civil española los consejos de guerra sumarísimos a la población civil fueron una de las estrategias utilizadas por elejército sublevado para extender el terror y acabar con la resis- tencia de quienes defendían la República. Juicios sin ninguna garantía legalque se iban celebrando según los territorios caían en manos rebeldes. Aunque la cifra de hombres que fueron ejecutados tras estos juicios esmucho mayor que la de las mujeres, no fueron pocas las que sufrieron el mismo destino. Este artículo se centra en la vida de una de esas mujeresanónimas que fueron ejecutadas durante la guerra. Se trata de Polonia Mateos Pérez, una matrona extremeña que después de un breve consejo de guerra sumarísimo acabó delante de un piquete de ejecución en Cáceres en enero de 1938.
EFL Teachers’ Perceptions of the Challenges of Technology-Based Professional Development
Authors: ZHOU GUANBING , ESLAMI ZOHREH R.
Published: December 2023

Pre-service teacher professional development could assume an urgent part in raising teaching quality and learning outcomes. Evolving technologies allow for new and different forms of professional development. However, teacher professional development opportunities are limited and outcomes are controversial. In this study, to capture the challenges of a technology-based professional development, the researchers examined teachers’ perceptions of the barriers to technology integration and instructional practices. Three hundred participants were recruited through an online survey- Technology-Based Professional Development Questionnaire. Through employing Structural Equation Modeling (SEM), the researchers analysed the data. The results of the study indicated that the gap between information and the use of technology-based apparatuses was viewed as related with the difficulties confronting teachers with technology-based directions. Technology-literate teachers knew how to integrate their insight into their commonsense instructing and had higher students’ commitment and inspiration. In any case, technology-illiterate teachers had mechanical troubles that reduced their education. A few ramifications can be drawn from the review, for example, the requirement for teacher instruction projects to further develop teacher consciousness of new educational innovative learning strategies, and the significance of giving chances to get computerized proficiency. Our findings have both theoretical and practical implications for pre-and in-service teacher training programs. Based on these discoveries, suggestions for the plan of online professional development and gaps for future examinations are discussed.
Exploring Chinese EFL teachers’ professional identity tensions in the senior high school context: A dissonance theory perspective
Authors: PAN MINGQIONG , KIRKPATRICK ROBERT
Published: December 2023

Due to the great importance of professional identity in teachers’ development and success, researchers’ attention has recently been confined to the tensions that may challenge teachers’ identities. Despite the importance of these tensions in the EFL context, only a few studies have addressed them by employing qualitative research methods. The present study aims to investigate the professional identity tensions of EFL teachers by a psychometric scale. Therefore, an instrument was developed and validated for measuring Chinese EFL teachers’ professional identity tensions from the Dissonance Theory perspective by adopting the Professional Identity Tension Scale (PITS). To this end, based on the convenience sampling method, 452 Chinese EFL teachers from senior high schools participated in the study. Exploratory and SEM analyses were performed to identify and confirm the weight of the influencing factors respectively. The final instrument is a 5-point Likert-type item including 30 items measuring six different tensions related to professional identity. The findings were an indication of the applicability of PITS in the EFL context with six contributive factors. Implications of the study and suggestions for further research are discussed.
Investigating the effects of emotion regulation and creativity on Chinese EFL teachers’ burnout in online classes
Authors: LI HOATING
Published: December 2023

The spread of the Coronavirus and the emergence of new technology have led to an abrupt shift in education and changed the mode of instruction. The new mode of instruction has faced teachers with new challenges, which may enhance the rate of job burnout. To avoid this phenomenon, the causes of teacher burnout in online classes should be widely identified. With this in mind, this inquiry investigated the effects of emotion regulation and creativity on EFL teachers’ burnout in online classes. We hypothesized that teachers’ creativity and ability to regulate their emotions can minimize the rate of burnout. To test this hypothesis, 329 Chinese EFL teachers were invited to respond to three validated questionnaires. The collected data were analysed through Structural Equation Modelling (SEM). The study outcomes revealed a significant correlation between Chinese EFL teachers’ creativity, emotion regulation, and burnout. The results also showed that creativity and emotion regulation can make a significant change in the rate of teacher burnout. The present results are hoped to be illuminating for all online English teachers.
FUNDING INFORMATION. This work was supported by Ningbo University Teaching Research Project “Research on teaching strategy of ideological and political theory course based on acceptable psychology of college students” (JYXMXZD2023040).
A phenomenological inquiry into prospective EFL teachers’ perceived sense of belonging in school placement
Authors: ÜNSAL-GÖRKEMOĞLU BÜŞRA , SOLHI MEHDI
Published: December 2023

While the sense of belonging has seen a surge of interest in the field of social psychology, there has been a scarcity of research on the construct during school placement in initial teacher education (ITE) programs. The present study set out to explore the sense of belonging experiences of three prospective English as a foreign language (EFL) teacher during school placement along with the contributing factors involved in establishing a sense of belonging. The findings from exploratory focus group interviews with the participants and their graphic elicitation tasks revealed that interpersonal relationships and institutional factors possess essential roles in establishing a sense of belonging during school placement. Finally, pedagogical implications are discussed so as to enhance the effectiveness of school placement designs in ITE.
Assessing the effectiveness of educational work in a general education organization: Classification of information to be used in the document-oriented system ‘MongoDB’
Authors: Bazhenova Valentina Valeryevna , Leont’eva Nataliya Vladimirovna , Miroshnichenko Alexey Anatolyevich , Voronchikhina Olga Sergeevna
Published: December 2023

The study aims to substantiate the process of obtaining information to assess the effectiveness of educational work in a general education organization based on big data technologies. The paper presents the results of an online survey of specialists in the educational work of education organizations. Within the framework of this survey, the sources of information necessary for assessing the effectiveness of educational work in a general education organization are specified and ranked. The big data technologies that are most suitable for assessing the effectiveness of educational work in a general education organization are analyzed. The scientific novelty of the study lies in the fact that the sources of information and a system of attributes that allow classifying the information necessary to be used when assessing the effectiveness of educational work in a general education organization based on big data technologies are specified. As a result of the study, it has been found that the document-oriented system ‘MongoDB’ can be used to assess the effectiveness of educational work in a general education organization.
Features of professional self-actualization of university students – future secondary school teachers taking into account the level of development of the non-verbal component of their social intelligence
Authors: Dmitrieva Anna Vsevolodovna
Published: December 2023

The work aims to identify the features of professional self-actualization of university students – future secondary school teachers in connection with the development of the non-verbal component of their social intelligence. The paper describes the process of conducting a study consisting of the theoretical and the empirical stages and oriented towards achieving the specified aim. The scientific novelty of the research lies in identifying the nonlinear nature of the relationships between the features of professional self-actualization of future teachers and the level of development of the non-verbal component of their social intelligence. As a result, the work has shown that the majority of future teachers have an average level of development of socio-perceptual abilities (the non-verbal component of social intelligence) and an average level of self-actualization. Concerning university students – future secondary school teachers, self-actualization and the level of development of the non-verbal component of their social intelligence are interrelated, but these relationships are nonlinear. Teachers with the low level of socio-perceptual abilities have less pronounced components of self-actualization, such as time orientation, values and creativity (compared with teachers with both high and medium levels of socio-perceptual abilities).