bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring Updates to Performance Evaluation Terminology
Authors: Conzelmann Julie D.
Published: February 2022

The goal of this research was to obtain feedback and perspectives from human resource experts regarding the applicability of a newly created performance evaluation document. Reviewed literature includes sources indicating the documentation for employee performance evaluations have not been revised in decades. No recent literature was found regarding updating performance evaluations. Through an exploratory case study, human resource experts helped discern the need to update performance evaluation documents, including the 11 most recognized organizational citizenship behaviors. Purposive and snowball participant selection comprised five qualifying human resources subject matter experts representing healthcare, business, retail, manufacturing, and education from various cities in the United States. Findings revealed the need for organizations to update performance evaluations from the current antiquated and generic documents that only measure basic job-task performance. The outcome was agreement that human resource leaders should update their performance evaluation document to Exhibit B. Results empirically confirmed human resource leaders would support an updated performance evaluation document, substantiating my argument that the newly created performance evaluation document would be beneficial to everyone by fully recognizing and measuring the value of all employee contributions in the workplace.
The Role of Integrated Reporting in Enhancing Corporate Transparency and Communication
Authors: Mock Marcel , Gonzálvez-Gallego Nicolás , Razik Stefan
Published: February 2022

The primary purpose of the research is to analyze and evaluate the prospects for the success of Integrated Reporting in terms of its potential to increase corporate transparency and enhance corporate communication. The relevance of the decision of this scientific problem is that the European Union published a proposal for the Corporate Sustainability Reporting Directive in April 2021 that highlights the importance of intangible assets and value creation. The Directive serves to ensure companies provide consistent and comparable sustainability information. In this context, it places sustainable reporting on par with financial reporting. Systematization of the literary sources and approaches indicates that company reports developed from a financial perspective over the triple bottom line sustainability approach to an integrated approach. Moreover, stakeholders are increasingly demanding more information. Reducing information asymmetries has always been an essential task of company reports. Consequently, the primary purpose of this research is to identify whether Integrated Reporting, according to The International Integrated Reporting Framework, is a successful tool to enhance corporate transparency and communication. Integrated Reporting presents financial and non-financial information against the background of their contribution to value creation. Methodological tools of the research are a research synthesis and meta-analysis literature review. These instruments are developed and enriched using document analysis and systematic content analysis. The research findings suggest that integrated reports enhance transparency and communication, leading to more trust and resilience. Moreover, the results indicate that the principle-oriented framework and the Guiding Principle Materiality enable companies to respond to their specific characteristics to meet the stakeholders’ requirements. The research empirically confirms and theoretically proves that Integrated Reporting can be seen as a suitable instrument for creating greater transparency, thus, a further development step in corporate reporting and communication. Integrated Reporting should therefore not be understood exclusively as a separate reporting tool but rather as a holistic management approach to implement integrated corporate management. The research results are beneficial for academic researchers and practitioners since the research provides an insightful and comprehensive overview of Integrated Reporting. Furthermore, it is also possible to derive practical recommendations for the application of Integrated Reporting.
Trust in Vaccination as a Factor in Public Health During a Pandemic
Authors: Kuzmenko Olha , Kolomiiets Svitlana
Published: February 2022

The article summarizes the arguments in the scientific debate on public trust in vaccination against COVID-19. The main purpose of the research is to model the trend of changes in the trust in vaccination against COVID-19, analyzing time series by exponential smoothing. The object of the study is the public trust in vaccination against COVID-19. The research aims to model the changing trend of the trust in the vaccination against COVID-19 using time series analysis. Systematization of literature sources and approaches to solving the vaccination problem during the pandemic showed that various psychological, social, economic factors, including trust in official information, affect the level of trust in vaccination. Declining confidence in the authorities, medical institutions, social institutions, and the media significantly impacts the effectiveness of pandemic containment measures. The trust of the population in state institutions in scientifically based information on vaccination provides the necessary level of vaccination during the COVID-19 pandemic. The study regarding the changing trend in the level of trust in vaccination against COVID-19 analyzing time series by exponential smoothing in the article is carried out in the following logical sequence: 1) Internet users on the issues of “Trust in vaccination against COVID-19”, “Vaccination against COVID-19”, “Trust in vaccination” was carried out using Google Trends; 3) Statistica software package was used to implement exponential smoothing models. Predictive models of exponential smoothing based on the following indicators: “Trust in vaccination against COVID-19”, “Trust in vaccination”, “Vaccination against COVID-19” are constructed. Time series models related to public confidence in COVID-19 vaccination demonstrate the presence of a seasonal component every two weeks. The results of the study can be useful for the development of scientifically sound recommendations to control the vaccination process during a pandemic, to build predictions of the level of trust in vaccination against COVID-19.
Higher-order topological superconductors from Weyl semimetals
Authors: Jahin Ammar , Tiwari Apoorv , Wang Yuxuan
Published: February 2022

We propose that doped Weyl semimetals with {time-reversal and certain crystalline symmetries} are natural candidates to realize higher-order topological superconductors, which exhibit a fully gapped bulk while the surface hosts robust gapless chiral hinge states. We show that in such a doped Weyl semimetal, a featureless finite-range attractive interaction favors a p+ip pairing symmetry. By analyzing its topological properties, we identify such a chiral pairing state as a higher-order topological superconductor, which depending on the existence of a four-fold rotoinversion symmetry, is either intrinsic, {meaning that the corresponding hinge states can only be removed by closing the bulk gap, rather than modifying the surface states}, or extrinsic. We achieve this understanding via various methods recently developed for higher-order topology, including Wannier representability, Wannier spectrum, and defect classification approaches. For the four-fold rotoinversion symmetric case, we provide a complete classification of the higher-order topological superconductors. We show that such second-order topological superconductors exhibit chiral hinge modes that are robust in the absence of interaction effects but can be eliminated at the cost of introducing surface topological order.
Toward Novel Antioxidant Drugs: Quantitative Structure-Activity Relationship Study of Eugenol Derivatives
Authors: Widiakongko Priyagung Dhemi , Triatmaja Karisma
Published: February 2022

The study of the Quantitative Structure-Activity Relationship (QSAR) of eugenol compound and its derivatives towards antioxidant activities was conducted using electronic and molecular descriptors. These descriptors were generated from semi-empirical chemical computation with PM3 level of theory. The QSAR model in this research could be used to predict novel antioxidant compounds which are more potent. The activity of the compound determined based on the IC50 value (Inhibition Concentration 50%) was linked with the descriptor results that had been calculated in a QSAR equation. The data showed that the descriptors that had a significant effect were a net charge of C-6, C-7, O-12, and HOMO energy and hydration energy. The best QSAR equations obtained with these descriptors and their parameters are shown as follows.log1/IC50 = - 3,3026 (± 0,4066) qC6 - 4,7450 (± 0,7224) qC7 + 3,2746 (± 0,6752) qO12 + 0,6326 (± 0,0645) HOMO - 0,0086 (± 0,0011) hydration energy + 4,8053 (± 0,6336)(n = 8 ; R = 1,000 ; s = 0,004 ; F = 3655,537 ; p = 0,0003 ; Q2 = 0,988 ; SPress = 0,039 ; SDEP = 0,021)
La declinación de la autoridad docente en la contemporaneidad: una perspectiva psicoanalítica
Authors: Dasuky Quiceno Samir Ahmed , González Vargas Juan Pablo
Published: February 2022

Este artículo presenta una reflexión sobre la autoridad docente en el contexto de la cultura actual, marcada por los discursos del capitalismo y de la ciencia, de los cuales surge una nueva subjetividad. El objetivo de este trabajo es discurrir sobre la incidencia de los discursos del capitalismo y de la ciencia en la declinación de la autoridad docente. En un primer momento, se aborda el proyecto y la subjetividad moderna fundados en los productos de la razón; posteriormente, se indica cómo dicho proyecto entra en una fase de sospecha, por sus efectos en el siglo XX y por la crítica realizada por los maestros de la sospecha. Luego se desarrolla la declinación de la función del padre por la incidencia del discurso del capitalismo, continuando con las consecuencias subjetivas de la declinación de la autoridad docente que genera una nueva subjetividad basada en los derechos individuales hedonistas, para finalizar con la declinación de la autoridad docente, entendida desde dos perspectivas: empresarial y epistémica, que tienen por consecuencia la forclusión de la singularidad. Se concluye que el lugar de la autoridad docente es afectado por dos elementos: primero, por el discurso del capitalismo en su relación con el discurso de la ciencia porque borra la disimetría del lazo social, donde el vínculo docente-estudiante se torna simétrico marcado por el valor de la igualdad; y segundo, por el empuje al Uno de la estandarización del conocimiento dado por políticas educativas internacionales en las que el docente es un instrumento.
Potencial de disparidad o Mismatch negativity y P3a en pacientes con esquizofrenia
Authors: Rojas Bernal Luz Angela , Bareño Silva José , Duque Grajales Jon Edinson , Agudelo Baena Lina María , Castaño Pérez Guillermo Alonso
Published: February 2022

Antecedentes: la esquizofrenia es una enfermedad crónica que genera gran discapacidad, para la cual se han reportado biomarcadores potenciales, pero sin suficiente validez clínica. El mismatch negativity (MMN) y el P3a son potenciales relacionados con eventos que han demostrado ser indicadores neurofisiológicos del procesamiento auditivo pre-atencional y potenciales biomarcadores. Objetivo: evaluar el MMN y P3a en pacientes con diagnóstico de esquizofrenia y su relación con variables sociodemográficas y clínicas. Método: estudio cuantitativo transversal de 23 sujetos con esquizofrenia (ESQ) y 22 controles sanos (SN). Las amplitudes promedio y latencias del MMN/P3a para la condición infrecuente en duración y frecuencia fueron obtenidas mediante un paradigma oddball auditivo en un EEG de 32 canales. Resultados: se encontraron diferencias para la condición frecuencia en la amplitud del MMN (p=0.046; CI 95% 0.009; 0.87) y la amplitud del P3a (p=0.042; CI 95% 0.025; 1.24) entre los grupos; la amplitud del MMN fue menor en el grupo ESQ (-0.36 DE 0.51 µV) en comparación con los participantes del grupo de SN (-0.81 DE 0.89 µV), mientras que la amplitud del P3a fue menor en el grupo SN (0.18 DE 0.97 µV) versus el grupo ESQ (0.82 DE 1.05 µV). En relación con las variables sociodemográficas y clínicas, las asociaciones con el P3a fueron moderadas y con el MMN débiles. Conclusiones: la reducción de la amplitud del MMN a la condición frecuencia exhibe mayor utilidad que el P3a como medida de alta estabilidad en pacientes con esquizofrenia, lo que reitera su posible uso como biomarcador.
Relationship among Materialism, Attitudes Regarding Money, Peer Influence and Satisfaction with Life in Chilean Adolescents
Authors: Denegri Coria Marianela , Peñaloza Verónica , Sepúlveda José , Riquelme Leonor
Published: February 2022

Materialism has been recognized as an important variable in postmodern societies; however, most of the studies on this concept have focused on the adult population. The aim of the present study is to determine the possible association between materialism and life satisfaction, and the possible mediating role of attitudes towards money and peer influence in this association, in a sample of Chilean adolescents. A sample of 1325 Chilean secondary school students completed a questionnaire measuring materialism, attitudes in regards with money, susceptibility to peer influence, and satisfaction with life. First, a confirmatory factor analysis was conducted to validate the scalers. Secondly, a theoretical model was tested using Hayes (2013) SPSS macro, PROCESS. The theoretical model included materialism as the predictor variable, satisfaction with life as the predicted variable, and attitudes towards money and susceptibility to peer influence as mediator variables. Results indicate that materialistic attitudes regarding money strengthens a negative relation between materialism and satisfaction with life. This tendency is not observed in susceptibility to peer influence despite being positively associated with materialism and attitudes regarding money. These findings suggest that the variables materialism and attitudes regarding money play a relevant role in the life satisfaction of Chilean adolescents.
Psychometric properties of the Perceptions of Organizational Politics -POPS- Scale in Puerto Rico
Authors: Velez Vega Abner
Published: February 2022

Background: perceptions of organizational politics have many consequences on work behavior. Therefore, organizational politics has gained an interest in research examining the influential factors and behaviors in which organizations operate over the past few years. Objectives: this work aims to explore and present the psychometric properties of the Perceptions of Organizational Politics Scale adapted version. Method: a quantitative study of cross-sectional and instrumental type design in a sample of 205 participants representing public and private working sectors in Puerto Rico and the analysis carried out to verify the factorial structure of the scale and the reliability and validity indicators. Results: the Confirmatory Factor Analysis with Structural Equation Modeling showed better fit indices and a three-factor structure according to the original scale and obtained optimal internal consistency values for each factor. Conclusion: this study provides an instrument for both researchers and professionals to study the phenomenon of organizational politics in the workplace and organizations and allows them to contribute new studies and literature in Puerto Rico.
Incorporating non-uniformity and non-linearity of hydrologic and catchment characteristics in rainfall–runoff modeling using conceptual, data-driven, and hybrid techniques
Authors: Vidyarthi Vikas Kumar , Jain Ashu
Published: February 2022

The rainfall–runoff (RR) process in a catchment is non-uniform, complex, dynamic, and non-linear in nature. Although a number of advanced conceptual and data-driven techniques have been proposed in the past, the accurate estimation of daily runoff still remains a challenging task. A majority of conceptual models proposed so far suffer from the assumptions of linearity during their modeling. In this paper, novel hybrid approaches are proposed that are capable of exploiting the strength of both conceptual and data-driven techniques in RR modeling. A conceptual technique is first used to generate sub-basins’ runoff hydrographs in upstream reaches and then data-driven techniques are employed for routing them to the outlet of the catchment. The hybrid models’ performances are compared with standalone conceptual and data-driven models by employing the daily rainfall, runoff, and temperature data derived from the Kentucky River basin, USA. The results show that the proposed hybrid models, which do not assume the RR process to be a linear process to simulate the flow, outperform their individual counterparts. It is concluded that in order to achieve improved accuracy in RR modeling, the real-life process needs to be represented as accurately as possible in the modeling effort rather than making simplified assumptions.
Occurrence of pathogenic microorganisms in small drinking-water systems in Costa Rica
Authors: Barrantes Kenia , Chacón Luz , Morales Eric , Rivera-Montero Luis , Pino Macario , Jiménez Alejandra Gamboa , Mora Diana Campos , Jiménez Pablo Salas , Silva Basilio , Romero-Esquivel Luis G.
Published: February 2022

This study describes the quality of drinking water sampled over 2 years (2018 and 2019) from 20 ASADAS (Spanish acronym for Administrative Associations for Water and Sewer Systems) in Costa Rica. The analysis included Rotavirus (RV), somatic coliphages, fecal coliforms, and Escherichia coli. The ASADAS were categorized into three regions as temperate rainy (region 1), tropical rainy (region 2), and tropical rainy and dry (region 3) according to biogeographic classification. The concentrations of fecal coliforms and E. coli were higher in samples from surface water sources from the ASADAS in region 3 compared to regions 1 and 2. RV-positive samples (24/296) were detected in drinking-water samples from regions 2 and 3 during dry and transition seasons, with higher concentrations more frequently in the dry season. In addition, somatic coliphages were detected in samples from the three regions, with higher concentrations in region 2. Furthermore, a statistically significant relationship was found between somatic coliphages and diarrheal cases, classified as outbreaks or alerts in the region. Thus, the results confirmed that somatic coliphages are a good indicator of the presence of diarrhea cases in a specific region.
Performance evaluation of an HDH desalination system using direct contact packed towers: experimental and mathematical modeling study
Authors: Zarei Taleb , Miroliaei Mohammad Reza
Published: February 2022

Humidification–dehumidification desalination (HDH) is one of the suitable methods for desalination of saline and brackish water in a small scale. In this research, an HDH desalination method with a direct contact dehumidifier has been analyzed theoretically and experimentally. The setup consists of two similar packing towers for humidification and dehumidification, 10 inches in diameter, which are filled up to 1 m with Rushing packing. In this new HDH configuration, seawater and freshwater recirculation has been used in humidifier and dehumidifier sections, respectively. A steady-state mathematical model based on the mass and energy equations for each system component is presented. The effect of various input parameters on the freshwater production, gain output ratio (GOR) and specific energy consumption has been investigated. The results revealed that the inlet seawater and air temperature to the humidification tower had the highest and the lowest effect on the produced freshwater, respectively. Also, the maximum value of the GOR is 3.3, which is obtained in the equilibrium condition of the dehumidifier. The experiments show that the freshwater production of the proposed HDH device is 300 L/day, which can provide water for the domestic consumption of a small family.
Development and performance of a dynamic membrane for anaerobic wastewater treatment – an analysis with different mesh pore sizes and configurations
Authors: Fonseca Paula Rafaela Silva , Mora Erick Javier Centeno , Batista Isabela Ferreira , Chernicharo Carlos Augusto de Lemos
Published: February 2022

Recent studies have focused on proposing materials with larger pores and lower cost to replace conventional membranes. This study aims to investigate the performance of an anaerobic dynamic membrane bioreactor (AnDMBR) at pilot scale, acting as a post-treatment for an Upflow Anaerobic Sludge Blanket (UASB) reactor treating sewage, for the removal of complementary organic matter, focusing on the module design, dynamic layer formation and process performance. The configurations tested on this study were: UASB followed by stone filter and three AnDMBRs in series with polyester pore sizes of 100 μm, 50 μm, and 5 μm; UASB followed by disc filter and the three AnDMBRs in series; UASB followed by the three AnDMBRs in series; and UASB reactor with only one AnDMBR module. Regarding the studied configurations, high removals of total suspended solids, chemical oxygen demand, and turbidity were achieved in all experimental setups. The use of stone and disc filters did not bring clear benefits to the system concerning the direct application of filtration with dynamic membranes, therefore, their removal in the system was favorable. The dynamic membrane formation was faster in the 50 μm mesh, and only a few hours were necessary to obtain a permeate quality with a total suspended solids concentration and a turbidity lower than 15 mg·L−1 and 30 NTU, respectively. Thus, the dynamic membrane technology proved to be a potential solution in the post-treatment of UASB reactor effluents.
ENSINO DE PROJETO HABITANDO OS TERRITÓRIOS HABITADOS: DERIVA E CARTOGRAFIA
Authors: Hirao Helio , Zaia Nogueira Ramos Alfredo , Nunes João
Published: February 2022

Trata-se de uma experimentação de procedimento metodológico do ensino de projeto arquitetônico realizada no segundo ano do curso de Arquitetura e Urbanismo da UNESP Campus de Presidente Prudente (2019), a partir da prática espacial de derivas e cartografias de forças e afetos, potencializando uma interlocução transversal com a disciplina de geomorfologia. A experimentação retarda o encontro com as analogias tipológicas para conceber as formas arquitetônicas, realizando uma imersão na tessitura das relações de afetos que atravessam os corpos (humano e arquitetônico). Afasta assim, dos procedimentos lineares e padronizados através da identificação e reconhecimento dos territórios que habitam o espaço. Desse modo, a proposta de elaboração de um centro comunitário em um bairro periférico de Presidente Prudente, SP, não buscou resolver seus problemas, mas ressingularizar práticas e afetos existentes, para potencializar o sentimento de pertencimento dos sujeitos com seu espaço, valorizando a transitoriedade da intervenção projetual de uma realidade em constante movimento e transformação, como também, projetando espaços indeterminados e flexíveis a serem determinados pelos sujeitos dos espaços.
O OLHAR COLETIVO E O PATRIMÔNIO URBANO DE ANTÔNIO PRADO/RS
Authors: Piccinato Junior Dirceu , Reginato Nauana da Costa , Cardoso Grace Tibério
Published: February 2022

Este estudo objetiva compreender a percepção afetiva do patrimônio cultural de Antônio Prado/RS. Mais especificamente, buscou-se identificar, mediante análise centrada na percepção afetiva do sujeito, o elo entre ambiente, sentimento de identidade e grau de pertencimento dos munícipes pradenses para com os bens patrimoniais da cidade, almejando caracterizar o olhar coletivo da comunidade local como vozes ativas para com a salvaguarda patrimonial. Metodologicamente, realizou-se pesquisa de campo com delineamento exploratório, onde aplicou-se um questionário sociocultural junto a uma parcela dos moradores para construir uma visão do tipo aproximativa. Antônio Prado mantém preservado um dos mais importantes testemunhos do legado cultural da imigração italiana no Brasil. Trata-se de construções edificadas pelos imigrantes que se revestem de simbolismo histórico e arquitetônico. Os casarões permaneceram preservados por mais de um século e, no ano de 1990, 48 deles foram tombados pelo IPHAN. Para conquistar o tombamento, um longo e burocrático caminho foi percorrido, já que na época as construções de origem do processo de colonização italiana ainda não eram devidamente valorizadas pelas autoridades e pela própria comunidade local. Para tanto, no ano de 2021, as análises perceptivas demonstram que, ainda não há pleno consenso entre os sujeitos deste estudo de que o tombamento do conjunto se configura, de fato, como um aspecto relevante. Todavia, os resultados obtidos mostraram-se positivos no sentido de uma nova concepção do patrimônio e da sua gestão com espaço para a participação dos diferentes atores sociais que exercem influência sobre a unidade territorial.
Substrate-dependent Inhibition of Hypericin on Human Carboxylesterase 2: Implications
for Herb-drug Combination
Authors: Wang Dalong , Zhao Tingting , Zhao Shan , Chen Jing , Dou Tongyi , Ge Guangbo , Wang Changyuan , Sun Huijun , Liu Kexin , Meng Qiang , Wu Jingjing
Published: February 2022

Background:

Hypericin is the main active ingredient of St. John’s wort, a Chinese herb commonly used
for treating depression. Previous studies shown that hypericin can strongly inhibit human cytochrome P450 (CYP)
enzyme activities; however, its potential interactions that inhibit human carboxylesterases 2 (hCE2) are unclear.

Purpose:

This study aimed to investigate the inhibitory effect of hypericin on hCE2.

Methods:

The inhibition mechanism of hypericin on hCE2 was studied by using N-(2-butyl-1,3-dioxo-2,3-dihydro-
1H-phenalen-6-yl)-2-chloroacetamide (NCEN). The type of inhibition of hypericin on hCE2 and the corresponding
inhibition constant (Ki) value were determined. The inhibition of hypericin on hCE2 in living cells was discussed.
The risk of herb-drug interactions (HDI) of hypericin in vivo was predicted by estimating the area under the drug
concentration-time curve (AUC) in the presence or absence of hypericin. To understand the inhibition mechanism of
hypericin on the activity of hCE2 in-depth, molecular docking was performed.

Results:

The half-maximal inhibitory concentration (IC50) values of hypericin against the hydrolysis of NCEN and
irinotecan (CPT-11) were calculated to be 26.59 μM and 112.8 μM, respectively. Hypericin inhibited the hydrolysis
of NCEN and CPT-11. Their Ki values were estimated as 10.53 μM and 81.77 μM, respectively. Moreover, hypericin
distinctly suppressed hCE2 activity in living cells. In addition, the AUC of hCE2 metabolic drugs with metabolic
sites similar to NCEN was estimated to increase by up to 5 % in the presence of hypericin. More importantly, the
exposure of CPT-11 in the intestinal epithelium was predicted to increase by 2 % - 69 % following the oral coadministration
of hypericin. Further, molecular simulations indicated that hypericin could strongly interact with
ASP98, PHE307, and ARG355 to form four hydrogen bonds within hCE2.

Conclusion:

These findings regarding the combination of hypericin-containing herbs and drugs metabolized by
hCE2 are of considerable clinical significance.
CEA-regulated Oncolytic Virus Anticancer Therapy: A Promising Strategy
for Rare Solid Tumors
Authors: Zha Yan , Li Ning , Yang Yuqi , Wang Shuhang , Ma Peiwen , Tang Qiyu , Li Yandong , Fang Yuan , Zhu Qi , Tao Wei
Published: February 2022

Background:

Rare solid tumors have attracted much more attention due to the great unmet
clinical need, limited treatment options, and poor prognosis. As the most thoroughly studied tumor
marker, carcinoembryonic antigen (CEA) can not only overexpress in various common solid
tumors but also in several rare solid tumors. Oncolytic virus therapy has achieved excellent anticancer
effects in the past decades. Due to the specific high expression of CEA in certain tumor tissues
but not in normal tissues, CEA has been applied to improve the tumor specificity of gene expression.

Methods:

The studies of CEA expression in rare solid tumors and CEA-regulated oncolytic virus
therapy were reviewed.

Results:

We showed the types of rare solid tumors with the overexpression of CEA. Elevated
serum CEA levels can indicate the diagnosis, response of surgery or system therapy, distal metastasis,
recurrence, and survival. Due to high tumor specificity, CEA-regulated OA therapy has demonstrated
a surprising antitumor effect for common CEA-positive tumors in preclinical trials.

Conclusion:

These data suggested that CEA could be a diagnostic and prognostic biomarker for
several rare solid tumors. We proposed the hypothesis that CEA-regulated oncolytic virus therapy
could be a promising therapeutic strategy for CEA-positive rare solid tumors.
Design and Analysis of Pharmacokinetics, Pharmacodynamics and Toxicological
Analysis of Cannabidiol Analogs using In Silico Tools
Authors: Mendes Júnior Carlos Roberto , Costa Eduardo Damasceno
Published: February 2022

Background:

Cannabidiol (CBD), a non-psychoactive phytocannabinoid from Cannabis Sativa,
has become an interesting option for medicinal chemists in the development of new drug candidates.

Objective:

This study aims to propose analogs with therapeutic potential from the CBD scaffold.

Methods:

The 16 analogs proposed were designed using the PubChem Sketcher V. 2.4® software. Already,
CBD analogs were subjected to different in silico tools, such as Molinspiration®; SwissADME®;
SwissTargetPrediction®, and OSIRIS Property Explorer®.

Results and Discussion:

The screening of CBD analogs carried out in this study showed compounds 9
and 16 with a good affinity for interactions with CB1 and CB2 receptors. Pharmacokinetic data showed
that these two compounds have good oral absorption. Finally, in silico toxicity data showed that these
compounds pose no risk of a toxic event in humans.

Conclusion:

CBD analogs 9 and 16 would have a better profile of drug candidates to be further tested in
vitro and in vivo models.
Potential of Caffeic Acid Derivatives as Antimalarial Leads
Authors: Degotte Gilles , Pirotte Bernard , Frédérich Michel , Francotte Pierre
Published: February 2022

Background:

Malaria was one of the deadliest infectious diseases in 2021. Indeed, this infection,
mostly caused by a protozoan called Plasmodium falciparum, is responsible for more than 200 million
cases and around 400 000 related deaths annually, mainly in Africa. Despite the availability of effective
drugs, the number of patients has increased since 2015, which could be due to parasite resistance as
well as resistance in the pathogen's vectors, Anopheles mosquitoes. Consequently, it is necessary to search
for new alternative treatments.

Methods:

Polyphenols, more precisely small phenolic acids, could represent a good starting point for new
antimalarials. Indeed, these molecules, including caffeic acid (1), possess several pharmacological activities
and an interesting pharmacokinetic profile. Therefore, we have developed several small derivatives of
this scaffold to define the potential pharmacophore responsible for the antiplasmodial properties.

Results:

A good to low activity on Plasmodium falciparum (IC50 = 16-241 μM) was observed, especially
for the small ester derivatives (2-6). These molecules were good antiplasmodials compared to their mother
compound (IC50 = 80 μM) and showed selectivity against human cells. These structures have also highlighted
the need for catechol and carboxyl moieties in the anti-Plasmodium effect.

Conclusion:

None of the synthetic caffeate derivatives reported here seemed sufficiently effective to become
a potential antimalarial (IC50 < 1 μM). However, the significant increase of their efficacy on the
malarial agent and the selectivity to human cells highlighted their potential as new leads for future developments.
The Influence of Cultural and Psychological Factors on Mental Health Status during COVID-19 in Saudi Arabia
Authors: Alqahtani Azizah
Published: February 2022

Background:

The World Health Organization (WHO) announced a public health emergency of international concern (PHEIC) on 30 January 2020 due to the rapid increase in the number of COVID-19 cases outside China. Every pandemic is associated with other problems such as psychological and mental health problems.

Methods:

The current research investigated the relationship between mental health status and demographic variables and the psychological impact of COVID-19. Furthermore, this study explored the relationship between collectivism and low infection rates. The sample included 1700 adults aged 18 years and older. The questionnaire started with demographic questions followed by the Impact of Event Scale-Revised (IES-R), a scale that was applied to the COVID-19 outbreak, and the Depression, Anxiety and Stress Scale (DASS-21).

Results:

Findings indicated that depression, anxiety, and stress were associated with the psychological impact of COVID-19. In addition, students experienced a higher level of psychological impact of COVID-19 than other occupational groups. Finally, cultural collectivism was associated with a lower COVID-19 infection rate.

Conclusion:

It is recommended based on the findings of this paper that the mental health of university students should be observed and assessed during epidemics. Training regarding mental health should be provided to university faculty and staff.
Participatory Development in Community Health for the Pgazkoenyau Ethnic: A Case Study in an Ethnic Community in Thailand
Authors: Kitphati Rungrueng , Seangkeao Khampon , Muangyim Kamolnat , Nak-ai Worayuth
Published: February 2022

Background:

Most ethnic communities in Thailand were settled in remote areas with poor living conditions. Therefore, the “human-centered” concept was adopted to develop community health using the participation process.

Objective:

This research aimed to develop community health using the participation process at two Pgazkoenyau ethnic (Karen) communities whose environmental contexts were similar, in Tha Song Yang and Mae Ra Mard District, Tak Province.

Methods:

The multi-stage mixed methods design was applied for data collection. 24 participants were purposely recruited in the qualitative approach due to their responsibility as community health development operators. Qualitative data were collected using semi-structured interviews and analyzed using content analysis. In addition, quantitative data were gained through interview forms and laboratory test reports. Then they were analyzed using descriptive statistics, t-test to compare mean behavioral variables, and z-test to compare the proportion of two communicable diseases and blood chemical residues, with 95% confident interval.

Results:

The development process consisted of problem finding, data feedback and community stage, capacity building, operation, creative meeting, networking and social capitalizing. They could manage all activities following the community plan: identify helminthiasis and malaria cases, introduce cholinesterase test kits, improve community environmental health, improve healthy behaviors and build capacity for health promotion skills. Evaluated community activities showed increased scores concerning knowledge, attitudes and practices about disease prevention. The prevalence rate of helminths infection decreased significantly. The environmental context was also improved to enable the population’s healthy living conditions.

Conclusion:

Community development should be based on community resources and all available social and human capital for sustainable development.
Pengembangan Desa Pariwisata dengan Pemberdayaan Masyarakat dan Pemanfaatan Sumber Daya di Desa Hargotirto dan Hargowilis
Authors:   Jurusan  Teknologi Industri Pertanian,  Fakultas  Teknologi  Pertanian,  Universitas Brawijaya, Nurika Irnia , Meidiana Christia , Yudono Adipandang ,   Jurusan Perencanaan Wilayah dan Kota, Fakultas Teknik, Universitas Brawijaya, Suhartini Sri ,   Jurusan  Teknologi Industri Pertanian,  Fakultas  Teknologi  Pertanian,  Universitas Brawijaya, Wirawan Irawanto Dodi ,   Jurusan Manajemen, Fakultas Ekonomi dan Bisnis, Universitas Brawijaya
Published: February 2022

Kegiatan Doktor Mengabdi merupakan program yang dilaksanakan pada tahun2020 dan berlokasi di Desa Hargotirto dan Hargowilis, Kecamatan Kokap, Kabupaten Kulon Progo, Daerah Istimewa Yogyakarta. Pengembangan desa wisata bertujuan untuk menarik wisatawan agar mengunjungi desa tersebut sehingga dapat meningkatkan pendapatan. Desa Hargotirto dan Hargowilis memiliki beragam potensi baik sumber daya alam maupun sumber daya manusia yang dapat dikembangkan. Keduanya memiliki beberapa destinasi wisata yang menarik minat wisatawan. Namun masih terdapat permasalahan yaang perlu dicarikansolusinya agar sektor pariwisata di kedua desa tersebut dapat optimal. Program Doktor Mengabdi ini dilaksanankan dengan kegiatan Kuliah Kerja Nyata (KKN) kolaborasi UGM, ITB dan Enhance project. Program tersebut menghasilkan dua masterplan dengan beberapaoutput antara lain executive summary, leaflet, dan booklet. Output yang telah dihasilkan dari kegiatan pada program DM ini diharapkan dapat berguna dan bermanfaat bagi pemerintah setempat serta masyarakat sebagai rekomendasi dalam merencanakan dan mengatasi permasalahan yang ada di Desa Hargotirto dan Hargowilis sebagai desa pariwsata.
Prevention Of Mental Health Problems Among School-Age Children Through Establishment Of Mental Health Alert School
Authors:   Ilmu Keperawatan,Fakultas Kedokteran,Universitas Brawijaya, Hidayah Ridhoyanti
Published: February 2022

Many things cause mental health problems when children are at school. It is not known by both parents and the school. Therefore, it harms student behavior and academic achievement. These impacts can be addressed through education and training for teachers, staff, parents, and students on promotive and preventive measures for mental health problems. The earlier all people know about mental health, the sooner the child's condition will return to normal. This effort is carried out through collaboration among schools, parents, students, and health workers continuously. The results of the activity showed that most parents, teachers, staff, and students did not know about mental health problems, especially in school-age children, as well as prevention and earlyhandling efforts that could be carried out. Some teachers still have the old paradigm of mental health problems, so the prevention and treatment in overcoming deviant student behavior are still focused on short-term outcomes. The results of this activity can be used as a reference for parents and school to be aware of any signs of actual mental health problems around them. The School Mental Health Unit as a new program in the school is expected to be able to carry out its role as a center for handling mental health problems. Teacher councils and staffs can work together to carry out counselling to parents and students to deal with problems experienced by students. It must be a team that can help students improve their mental health status.
Memanfaatkan Internet of Aquaculture dalam Meningkatkan Kualitas Produksi pada Kelompok Pembudidaya Ikan Koi di Blitar
Authors:   Fakultas Perikanan dan Ilmu Kelautan, Universitas Brawijaya, Kilawati Yuni , Maimunah Yunita ,   Fakultas Perikanan dan Ilmu Kelautan, Universitas Brawijaya, Muttaqin Adharul ,   Fakultas Teknik, Universitas Brawijaya, Primanita Kartikasari Dany ,   Fakultas Ilmu Komputer, Universitas Brawijaya, Bhawiyuga Adhitya ,   Fakultas Ilmu Komputer, Universitas Brawijaya, Amrillah Attabik ,   Fakultas Perikanan dan Ilmu Kelautan, Universitas Brawijaya
Published: February 2022

Budidaya ikan Koi semakin berkembang karena stabilnya nilai jual dan jumlah penggemarnya. Salah satu daerahyang secara geografis memiliki kesesuaian untuk mengembangkan budidaya ikan Koi adalah Blitar. Produksi ikan Koi yang dihasilkan oleh pembudidaya di Blitar terkenal memiliki kualitas yang tidak kalah dibandingkan dengan Koi yang yang berasal dari negara lain sehingga konsumennya tersebar di seluruh dunia. Kondisi ini menuntut para pembudidaya untuk lebih baik lagi mengembangkan sistem budidaya untuk mempertahankan kualitas produksinya. Berdasarkan hasil survei dan komunikasi dengan UKM Garum Koi Community(GKC) di Blitar yang bergerak dalam bidang ini masalah yang sering dihadapi adalah tingginya kematian ikan yang disebabkan oleh penyakit. Penyakit ini diduga bersumber dari menurunnya kualitas lingkungan yang tidak tertangani secara baik sehingga menyebabkan penurunan kekebalan tubuh ikan Koi. Tujuan dari kegiatan ini adalah untuk memberikan edukasi dan pendampingan tentang upaya pencegahan kematian yang terjadi pada ikan Koi melalui pemberian imunostimulan berbahan alami dan kontrol kualitas air menggunakan alat yang berbasis internet kepada pembudidaya ikan Koi di Blitar. penggunaan bahan dan alat serta pemberian bantuan bahan imunostimulan dan alat detektor kualitas air berbasis internet
Pendampingan Perawat Dalam Optimalisasi Keberlanjutan Perawatan Ibu Nifas Dan Bayi Berat Badan Lahir Rendah (Bblr) Di Rumah
Authors:   Jurusan Keperawatan, Fakultas Kedokteran, Universitas Brawijaya, Melani Astari Asti , Choiriyah Muladefi , Evi Nurul , Merdikawati Ayut , Yuliatun Laily , Amaliya Sholihatul , Setyo Rini Ika , Adila Fitri Azizha , Ummu Raehana Niken ,   Jurusan Keperawatan, Fakultas Kedokteran, Universitas Brawijaya
Published: February 2022

Keberlanjutan perawatan ibu nifas dan bayi BBLR di rumah sangat penting dilakukan melalui pendampingan perawat. Tujuan pengabdian masyarakat ini untuk meningkatkan pengetahuan dan keterampilan ibu dalam perawatan nifas dan bayi prematur di rumah. Kegiatan ini dilakukan pada Januari-Maret 2020 dengan metode konseling secara homevisit. Ibu yang berpartisipasi dalam kegiatan ini adalah yang melahirkan bayi BBLR hidup dan bertempat tinggal di wilayah Malang & Batu. Pengumpulan data melalui kuesioner. Dua puluh lima responden ikut berpartisipasi memiliki tingkat pengetahuan baik (88%), parenting self-efficacy dalam kategori tinggi (84%), dan tingkat stress ringan (84 %). Hasil uji korelasi antara tangkas pengetahuan dengan parentingself-efficacy signifikan dan berkorelasi sedang (p-value =0.009; r =0.510). Sedangkan antara pengetahuan dan stress ibu tidak terdapat hubungan yang signifikan dalam merawat bayi BBLR di rumah (p-value =0,404; r =0,175). Kesimpulannya, pentingnya peningkatan pendampingan oleh tenaga kesehatan pada ibu nifas yang memiliki bayi BBLR di rumah
Analisis Dampak Penyebaran COVID-19 Terhadap Daya Beli Konsumen Berbasis Digital Platform. (Studi KasusMitra Go-Food, Gojek Region Malang
Authors:   Jurusan Teknik Industri, Fakultas Teknik, Universitas Brawijaya, L. Tri Wijaya N. Kusuma , Puspita Andriani Debrina , Nur Cahyawati Amanda , A. W Raditya ,   Jurusan Teknik Industri, Fakultas Teknik, Universitas Brawijaya
Published: February 2022

Evolusi virus Covid-19 dan dampak ekonominya yang tidak pasti menyulitkan untuk merumuskan respons kebijakan ekonomi yang tepat. Khususnya daya beli konsumen terhadap offline market. Dengan diimplemementasikannya kebijakan social distancing, hampir seluruh aktivitas dilakukan secara online. Termasuk aktivitas perdagangan online kebutuhan bahan pokok sehari-hari. Fitur aplikasi delivery online akan sangat berdampak. Salah satu fiturnya adalah pemesanan dan pengiriman makanan, Go-Food, sebagai perantara antara restoran, pengemudi, dan konsumen. Sebagai salah satu layanan digital platform, Go-Food juga mendorong pertumbuhan ekonomi Indonesia. Bukti ini mendukung pentingnya konsumsi Go-Food sebagai aplikasi mobile pemesanan makanan di Indonesia di masa pandemi. Namun, hanya beberapa riset yang menganalisis perilaku konsumen Indonesia dalam mengadopsi teknologi ini akibat dampak penyebaran Covid-19. Penelitian ini meyakini pentingnya memperhatikan pemetaan pola tingkat konsumsi masyarakat memandang teknologi aplikasi Go-Food dan korelasinya terhadap dampak dari kebijakan social distancing. Model hipotesis akan diuji menggunakan pemodelan korelasi linier dengan respons dari 200 konsumen Go-Food dan Mitra Merchant Go-Food yang dikumpulkan oleh survei online dan offline. Hasil penelitian ini akan memberikan wawasan yang akan bermanfaat tidak hanya untuk tujuan akademis dan teoritis melalui analisis yang kami lakukan, tetapi juga memberikan kontribusi kepada praktisi untuk meningkatkan manajemen logistik mereka dan memahami pasar mereka terutama di Indonesia selama masa pandemi
Optimalisasi Proses Produksi Nata de Coco Melalui Monitoring dengan Metode Absorbansi Serat Optik Berbasis Internet Of Things
Authors:   Jurusan Fisika, Fakultas MIPA, IPB University, Thalia Ananda , Hadinata Siregar Artha , Aviani Nurwinda Yulisa , Nurwinda Aviani ,   Jurusan Fisika, Fakultas MIPA, IPB University
Published: February 2022

Kegagalan produksi akan selalu ada dalam proses produksi nata de coco. Faktor kegagalan adalah suhu, kualitas air kelapa, kualitas bakteri Acetobacter xylinium, serta penggunaan cara manual dalam memantau proses produksi nata de coco. Faktor-faktor tersebut menyebabkan kualitas dan kuantitas nata de coco tidak optimal. Ditawarkan teknologi Moto-Coco yang bertujuan membantu produsen mengoptimalkan proses produksi nata de coco melalui monitoring produksi mulai dari bahan baku hingga proses produksi, dan menerapkan konsep Internet of Things. Teknologi tersebut menggunakan metode absorbansi serat optik melalui gelombang evanescent berbasis Internet of Things.
Otak Otak Bandeng Milenial, Diversifikasi Produk Bandeng Cabut Duri Untuk Segala Umur Dari Cv Anugrah Mitra Lestari
Authors:   Teknologi Hasil Perikanan, FPIK UB, Jl Veteran Malang, Kartikaningsih Hartati , Asmara Wati Lina , Primyastanto Mimit , Supriyadi Supriyadi , Ayu Christianty Putri Rhytia ,   Universitas Brawijaya
Published: February 2022

UMKM Anugrah Mina Lestari berkecimpung dalam usaha bandeng asap dan otak-otak bandeng milenial, yang berasa gurih dan disukai terutama anak-anak serta remaja. Permasalahan yang dialami mitra adalah bentuk dan berat setiap kemasan otak-otak bandeng tidak sama, dikemas tidak menggunakan pengemas vakum dan mencampur bahan baku ikan bandeng dan produk dalam satu freezer. Solusi yang ditawarkan untuk mengatasi permasalahan tersebut adalah dengan memberikan bantuan freezer, sausage stuffer dan vacuum sealer. Adanya bantuan peralatan ini mitra UMKM Anugrah Mina Lestari bisa memperbanyak produk, waktu pengolahan lebih singkat serta produk lebih awet
Gerakan Pakan Mandiri (Gepari) : Teknologi Pelet Ikan Solusi Pemberdayaan Kewirausahaan Santri (Santripreneur) di Pondok Pesantren Bahrul Maghfiroh Malang
Authors:   Fakultas Perikanan dan Ilmu Kelautan, Universitas Brawijaya, Maftuch Maftuch , Wilujeng Ekawati Arning , Yahya Yahya , Widya W Denny , Dedi Pratama Vian , Nadhila Nurin Febi ,   Fakultas Perikanan dan Ilmu Kelautan, Universitas Brawijaya, Sebastian Andhang
Published: February 2022

Unit usaha agrokompleks Pondok Pesantren Bahrul Maghfiroh ini dirintis untuk pengembangan di bidang budidaya ikan air tawar, mulai dari maksimalisasi produksi bahan bakupelet hingga pemenuhan sektor pembesaran ikan air tawar (lele, nila). Potensi permintaan pasar yang lebih tinggi di Malang menjadi peluang bagi pondok pesantren untuk berpartisipasi di bagian ini. Permasalahan yang dialami oleh seluruh pembudidaya yaitu lemahnya formulasi pakan ikan yang kurang, terutama limbah dan kurangnya pengetahuan formulasi pakan serta harga pakan saat ini melambung tinggi dan mulai membebani para pembudidaya. Oleh karena itu diperlukan inovasi baru untuk gerakan pakan mandiri yang memiliki kandungan gizi yang lebih baik dengan harga yang jauh lebih terjangkau serta menghasilkan keuntungan yang nyata. Permasalahan yang dialami oleh Pondok Pesantren Bahrul Maghfiroh dapat diatasi melalui penerapan Gerakan Pakan Mandiri (Gepari) dengan memanfaatkan bahan baku limbah peternakan, limbah sayuran. Hal ini dikarena kandungan nutrisi dan nutrisinya yang memenuhi konsep inovatif rampung majemuk