bluuebunny/crossref_metadata_2025 huggingface dataset:
Halogenated building blocks for 2D crystal engineering on solid surfaces: lessons from hydrogen bonding
Authors: Mukherjee Arijit , Sanz-Matias Ana , Velpula Gangamallaiah , Waghray Deepali , Ivasenko Oleksandr , Bilbao Nerea , Harvey Jeremy N. , Mali Kunal S. , De Feyter Steven
Published: March 2019

We test whether the similarities between halogen and hydrogen bonds could be used to design a surface-confined halogen-bond based network.
2-Bromo-6-(chlorodiisopropylsilyl)phenyl tosylate as an efficient platform for intramolecular benzyne–diene [4 + 2] cycloaddition
Authors: Nishii Arata , Takikawa Hiroshi , Suzuki Keisuke
Published: March 2019

An intramolecular benzyne–diene [4 + 2] cycloaddition with broad substrate scope has been realized by using a cleavable silicon tether, allowing access to various polycyclic structures.
Anisotropic strain release in a thermosalient crystal: correlation between the microscopic orientation of molecular rearrangements and the macroscopic mechanical motion
Authors: Seki Tomohiro , Mashimo Takaki , Ito Hajime
Published: March 2019

We report the salient effect of the crystal of gold complex that bridges the gap between macroscopic mechanical movements (i.e., jump) and microscopic changes of the crystal structure.
A simple and general route to prepare functional mesoporous double-metal oxy(hydroxide)
Authors: Jiang Yi-Fan , Jiang Nan , Liang Kuang , Yuan Cheng-Zong , Fang Xiao-Xiang , Xu An-Wu
Published: March 2019

We develop a simple and general solvothermal route to fabricate functional mesoporous double-metal oxy(hydroxides) with abundant oxygen vacancies through selective etching and topotactic transformation of metal hydroxides.
A novel ratiometric SERS biosensor with one Raman probe for ultrasensitive microRNA detection based on DNA hydrogel amplification
Authors: He Yi , Yang Xia , Yuan Ruo , Chai Yaqin
Published: March 2019

A ratiometric SERS biosensor with DNA hydrogel-captured glucose oxidase amplification method was fabricated to detect microRNA 122.
A hierarchical carbon nanotube/SiO2 nanoparticle network induced superhydrophobic and conductive coating for wearable strain sensors with superior sensitivity and ultra-low detection limit
Authors: Gao Jiefeng , Wu Lisheng , Guo Zheng , Li Jiye , Xu Cong , Xue Huaiguo
Published: March 2019

It is desirable to develop strain sensors with large stretchability, high sensitivity, and good anti-corrosive properties, due to their promising applications in wearable electronics.
Two RP-HPLC assay methods with different chromatographic approaches for the simultaneous estimation of bambuterol and its main degradation product, terbutaline
Authors: Walash Mohamed I. , Abo EL Abass Mohamed Samah
Published: March 2019

The present study describes two stability-indicating HPLC methods with two different chromatographic approaches for the simultaneous estimation of bambuterol and its main degradation product, terbutaline in bulk and pharmaceuticals.
A microscale double labelling of GAG oligosaccharides compatible with enzymatic treatment and mass spectrometry
Authors: Przybylski Cédric , Bonnet Véronique , Vivès Romain R.
Published: March 2019

Simultaneous reducing and non-reducing end labelling of GAG oligosaccharides on the microgram scale, compatible with both enzymes and MS analysis.
A strategy to improve the performance of cerium(iii) photocatalysts
Authors: Qiao Yusen , Cheisson Thibault , Manor Brian C. , Carroll Patrick J. , Schelter Eric J.
Published: March 2019

A structural modification strategy to improve the photocatalytic performance of molecular cerium(iii) luminophores was demonstrated.
A laser-induced TiO2-decorated graphene photoelectrode for sensitive photoelectrochemical biosensing
Authors: Ge Lei , Hong Qing , Li Hui , Li Feng
Published: March 2019

Direct-laser-writing of TiO2-decorated graphene on indium-tin oxide glass was demonstrated to fabricate a unique photoelectrode for sensitive photoelectrochemical biosensing.
Red-emitting pyrene–benzothiazolium: unexpected selectivity to lysosomes for real-time cell imaging without alkalinizing effect
Authors: Abeywickrama Chathura S. , Wijesinghe Kaveesha J. , Stahelin Robert V. , Pang Yi
Published: March 2019

Pyrene–benzothiazolium probe for visualizing lysosome in live cells.
Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery
Authors: Nam Keonwook , Kim Taehyung , Kim Young Min , Yang Kyungjik , Choe Deokyoung , Mensah Lawrence B. , Choi Ki Young , Roh Young Hoon
Published: March 2019

The size-tunable polymerized DNA nanoparticles (PDNs) for cancer-targeted drug delivery were synthesized via sequential processes of rolling circle amplification, condensation, and layer-by-layer assembly.
A robust wave-like silver–thiolate chain based metal–organic network: synthesis, structure and luminescence
Authors: Wang Jie , Li Yan-Ling , Wang Zhao-Yang , Zang Shuang-Quan
Published: March 2019

A wave-like silver–thiolate chain based metal–organic network has been prepared via facile one-pot synthesis, and shows ultra-stability and intense luminescence.
Gas-phase reactivity of CH3OH toward OH at interstellar temperatures (11.7–177.5 K): experimental and theoretical study
Authors: Ocaña Antonio J. , Blázquez Sergio , Potapov Alexey , Ballesteros Bernabé , Canosa André , Antiñolo María , Vereecken Luc , Albaladejo José , Jiménez Elena
Published: March 2019

New kinetic data and product distributions have been obtained using the experimental CRESU technique combined with a theoretical analysis of the reaction mechanism. The astrophysical implications of fast CH3O and CH2OH formation are discussed.
Resolution of mixed dyes by in situ near infrared (NIR) spectroelectrochemistry
Authors: Ibáñez David , Pérez-Junquera Alejandro , González-García María Begoña , Hernández-Santos David , Fanjul-Bolado Pablo
Published: March 2019

In situ NIR spectroelectrochemistry is a powerful technique for the resolution of mixtures, it allows to determine the composition of mixtures of molecules with similar structures.
Accurate analysis of Li isotopes in tourmalines by LA-MC-ICP-MS under “wet” conditions with non-matrix-matched calibration
Authors: Lin Jie , Liu Yongsheng , Hu Zhaochu , Chen Wei , Zhang Chenxi , Zhao Kuidong , Jin Xiaoye
Published: March 2019

The Li isotope of tourmalines can be accurately determined with a water-assisted method by (fs)ns-LA-ICP-MS.
Determination of major and trace elements in geological samples by laser ablation solution sampling-inductively coupled plasma mass spectrometry
Authors: Liao Xiuhong , Hu Zhaochu , Luo Tao , Zhang Wen , Liu Yongsheng , Zong Keqing , Zhou Lian , Zhang Junfeng
Published: March 2019

Water-related interferences and matrix effects in ICP-MS are dramatically reduced by using laser ablation solution sampling.
Investigation of the calcium-induced activation of the bacteriophage T5 peptidoglycan hydrolase promoting host cell lysis
Authors: Kovalenko Angelina O , Chernyshov Sergei V , Kutyshenko Victor P , Molochkov Nikolai V , Prokhorov Dmitry A , Odinokova Irina V , Mikoulinskaia Galina V
Published: March 2019

Peptidoglycan hydrolase of bacteriophage T5 (EndoT5) is a Ca2+-dependent l-alanyl-d-glutamate peptidase, although the mode of Ca2+ binding and its physiological significance remain obscure. Site-directed mutagenesis was used to elucidate the role of the polar amino acids of the mobile loop of EndoT5 (111–130) in Ca2+ binding. The mutant proteins were purified to electrophoretic homogeneity, the overall structures were characterized by circular dichroism, and the calcium dissociation constants were determined via NMR spectroscopy. The data suggest that polar amino acids D113, N115, and S117 of EndoT5 are involved in the coordination of calcium ions by forming the core of the EF-like Ca2+-binding loop while the charged residues D122 and E123 of EndoT5 contribute to maintaining the loop net charge density. The results suggest that Ca2+ binding to the EndoT5 molecule could be essential for the stabilization of the long mobile loop in the catalytically active “open” conformation. The possible mechanism of Ca2+ regulation of EndoT5 activity during bacteriophage T5’s life cycle through the Ca2+ concentration difference between the cytoplasm and the periplasm of the host bacteria cell has been discussed. The study reveals valuable insight into the role of calcium in the regulation of phage-induced bacterial lysis.
First report of silver ion recognition via a silatrane-based receptor: excellent selectivity, low detection limit and good applicability
Authors: Singh Gurjaspreet , Singh Akshpreet , Satija Pinky , Sharma Geetika , Shilpy Shilpy , Singh Jandeep , Singh Jasbhinder , Singh Kamal Nain , Kaur Amarjit
Published: March 2019

This study involves the synthesis of a silatrane-based receptor using Knoevenagel condensation and click chemistry approach for the recognition of silver ions in aqueous solution.
From fluorene molecules to ultrathin carbon nanonets with an enhanced charge transfer capability for supercapacitors
Authors: He Xiaojun , Xie Xiaoyu , Wang Jingxian , Ma Xiufang , Xie Yuanyang , Gu Jing , Xiao Nan , Qiu Jieshan
Published: March 2019

We report for the first time the fabrication of ultrathin carbon nanonets with an enhanced charge transfer capability for supercapacitors.
Particokinetics and in vitro dose of high aspect ratio nanoparticles
Authors: Price Seth Richard , Kinnear Calum , Balog Sandor
Published: March 2019

Adapting computational particokinetic models to address the dosage of high-aspect ratio nanomaterials for in vitro nanoparticle toxicology assays involving submerged adherent cell cultures.
C31-Selective substitution of cationic N-heteroaromatic groups into a 3-vinylated chlorophyll-a derivative
Authors: Takahashi Tatsuya , Ogasawara Shin , Echizen Shihoko , Shinozaki Yoshinao , Tamiaki Hitoshi
Published: March 2019

A variety of N-heteroarenes were C31-selectively introduced for a chlorophyll-a derivative through a C–N+ bond by using iodine and a silver(i) salt.
The influence of charging and discharging on the thermal properties of a carbon nanotube/polyaniline nanocomposite electrode
Authors: Duan Zheng , Luo Yufeng , Luo Zhiling , Yu Wei , Liu Changhong , Fan Shoushan
Published: March 2019

Fast charging/discharging process of the supercapacitors would generate a great deal of heat and influence their efficiency. In this paper, we investigate the influence of charging–discharging on the thermal properties of the CNT/PANI electrodes.
Multi-shelled ZnO decorated with nitrogen and phosphorus co-doped carbon quantum dots: synthesis and enhanced photodegradation activity of methylene blue in aqueous solutions
Authors: Song Shaojia , Wu Kun , Wu Huadong , Guo Jia , Zhang Linfeng
Published: March 2019

The presence of organic dyes in wastewater has posed a huge threat to aquatic life and human health.
Tailor-made synthesis of an melamine-based aminal hydrophobic polymer for selective adsorption of toxic organic pollutants: an initiative towards wastewater purification
Authors: Dey Debanjan , Chandra Murmu Naresh , Banerjee Priyabrata
Published: March 2019

Design and development of melamine based polyaminal covalent polymer (CPCMERI-2) for selective adsorption of organic pollutants over water surface: an initiative towards waste water purification.
Preparation, characterization and application in cobalt ion adsorption using nanoparticle films of hybrid copper–nickel hexacyanoferrate
Authors: Long Xinxin , Chen Rongzhi , Yang Shengjiong , Wang Jixiang , Huang Tijun , Lei Qin , Tan Jihua
Published: March 2019

CuxNiyHCF films with appropriate Cu/Ni ratios are expected to be prepared as designed for the recovery of Co2+ from spent LIBs.
Chemical and biological study of aplysiatoxin derivatives showing inhibition of potassium channel Kv1.5
Authors: Tang Yang-Hua , Wu Jing , Fan Ting-Ting , Zhang Hui-Hui , Gong Xiao-Xia , Cao Zheng-Yu , Zhang Jian , Lin Hou-Wen , Han Bing-Nan
Published: March 2019

New aplysiatoxin derivative (oscillatoxin E) exhibiting potent blocking activity against potassium channel Kv1.5 is consistent with molecular docking analysis.
Structural exploration of AuxM− (M = Si, Ge, Sn; x = 9–12) clusters with a revised genetic algorithm
Authors: Huang Ping , Jiang Yan , Liang Tianquan , Wu Enhui , Li Jun , Hou Jing
Published: March 2019

We used a revised genetic algorithm (GA) to explore the potential energy surface (PES) of AuxM− (x = 9–12; M = Si, Ge, Sn) clusters.
Controlling a burn: outer-sphere gating of hydroxylamine oxidation by a distal base in cytochrome P460
Authors: Smith Meghan A. , Majer Sean H. , Vilbert Avery C. , Lancaster Kyle M.
Published: March 2019

One amino acid makes the difference between a metalloenzyme and a metalloprotein in two otherwise effectively identical cytochrome P460s.
Monodisperse polysarcosine-based highly-loaded antibody-drug conjugates
Authors: Viricel Warren , Fournet Guy , Beaumel Sabine , Perrial Emeline , Papot Sébastien , Dumontet Charles , Joseph Benoît
Published: March 2019

A new antibody-drug conjugate (ADC) chemical drug-linker platform based on polysarcosine enables increased drug-loading, improved pharmacokinetics and exquisite in vivo potency.
Davydov splitting and singlet fission in excitonically coupled pentacene dimers
Authors: Basel Bettina Sabine , Hetzer Constantin , Zirzlmeier Johannes , Thiel Dominik , Guldi Rebecca , Hampel Frank , Kahnt Axel , Clark Timothy , Guldi Dirk Michael , Tykwinski Rik R.
Published: March 2019

Singlet fission (SF) allows two charges to be generated from the absorption of a single photon and is, therefore, potentially trans-formative toward improving solar energy conversion.
Upconversion-mediated ZnFe2O4 nanoplatform for NIR-enhanced chemodynamic and photodynamic therapy
Authors: Dong Shuming , Xu Jiating , Jia Tao , Xu Mengshu , Zhong Chongna , Yang Guixin , Li Jiarong , Yang Dan , He Fei , Gai Shili , Yang Piaoping , Lin Jun
Published: March 2019

ZnFe2O4, a semiconductor catalyst with high photocatalytic activity, is ultrasensitive to ultraviolet (UV) light and tumor H2O2 for producing reactive oxygen species (ROS).
Flow-induced translocation of vesicles through a narrow pore
Authors: Han Yunlong , Lin Hao , Ding Mingming , Li Rui , Shi Tongfei
Published: March 2019

We use finite element method to investigate the flow-induced translocation of vesicles through a narrow pore from a dynamic point of view.
MoSSe nanotube: a promising photocatalyst with an extremely long carrier lifetime
Authors: Zhang Shuai , Jin Hao , Long Chen , Wang Tao , Peng Rui , Huang Baibiao , Dai Ying
Published: March 2019

Janus MoSSe nanotube is a promising candidate for water splitting applications and presents an extremely long recombination time for electron–hole pairs.
Spatially confining and chemically bonding amorphous red phosphorus in the nitrogen doped porous carbon tubes leading to superior sodium storage performance
Authors: Wu Ying , Xing Feifei , Xu Rui , Cheng Xiaolong , Li Dongjun , Zhou Xuefeng , Zhang Qiaobao , Yu Yan
Published: March 2019

A rationally designed P/C anode with red P encapsulation into nitrogen doped porous carbon tubes demonstrates excellent sodium storage performance.
PtCu–O highly excavated octahedral nanostructures built with nanodendrites for superior alcohol electrooxidation
Authors: Wu Fengxia , Zhang Ling , Lai Jianping , Niu Wenxin , Luque Rafael , Xu Guobao
Published: March 2019

PtCu–O highly excavated octahedral nanostructures built with nanodendrites were synthesized and exhibit excellent activity for alcohol electrooxidation reaction.
An AIE-active theranostic probe for light-up detection of Aβ aggregates and protection of neuronal cells
Authors: Yang Yaqi , Li Shiwu , Zhang Qin , Kuang Ying , Qin Anjun , Gao Meng , Li Feng , Tang Ben Zhong
Published: March 2019

An AIE-active probe of Cur-N-BF2 is developed for light-up detection of Aβ fibrils and plaques, inhibition of Aβ fibrillation, disassembly of preformed Aβ fibrils, and protection of neuronal cells.
A spiro-silafluorene–phenazasiline donor-based efficient blue thermally activated delayed fluorescence emitter and its host-dependent device characteristics
Authors: Woo Seung-Je , Kim Youheon , Kim Yun-Hi , Kwon Soon-Ki , Kim Jang-Joo
Published: March 2019

A blue TADF emitter based on a spiro-connected silafluorene–phenazasiline donor with an EQE of 20.6% and CIE coordinates of (0.150, 0.184).
Signalling circuits that direct early B-cell development
Authors: Petkau Georg , Turner Martin
Published: March 2019

In mammals, the B-cell lineage arises from pluripotent progenitors in the bone marrow. During their development, B-cells undergo lineage specification and commitment, followed by expansion and selection. These processes are mediated by regulated changes in gene expression programmes, rearrangements of immunoglobulin (Ig) genes, and well-timed rounds of proliferation and apoptosis. Many of these processes are initiated by environmental factors including cytokines, chemokines, and cell–cell contacts. Developing B-cells process these environmental cues into stage-specific functions via signalling pathways including the PI3K, MAPK, or JAK-STAT pathway. The cytokines FLT3-Ligand and c-Kit-Ligand are important for the early expansion of the B-cell precursors at different developmental stages and conditions. Interleukin 7 is essential for commitment to the B-cell lineage and for orchestrating the Ig recombination machinery. After rearrangement of the immunoglobulin heavy chain, proliferation and apoptosis, and thus selection, are mediated by the clonal pre-B-cell receptor, and, following light chain rearrangement, by the B-cell receptor.
Survival prediction of tuberous sclerosis complex gene variant in patients with advanced non-small-cell lung cancer treated with platinum doublet
Authors: Ryu Jeong-Seon , Lim Jun Hyeok , Kim Hyun-Jung , Kim Min Jeong , Park Mi Hwa , Kim Jung Soo
Published: March 2019

Tuberous sclerosis complex (TSC) 1 and 2 function as tumor suppressors by inactivating the mammalian target of rapamycin (mTOR) pathway. Although the effect of platinum on TSC function has been studied, associations between TSC gene variants and survival of cancer patients treated with platinum-based chemotherapy were not evaluated. Genetic variants of TSC1 and TSC2 were identified by next-generation sequencing and selected for further clinical evaluation based on predetermined criteria. Associations of the gene variants with treatment outcomes (progression-free survival, PFS; overall survival, OS) were evaluated in testing and validation sets of patients with advanced non-small-cell lung cancer (NSCLC). Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated with the multivariable Cox model. The TSC1 Met322Thr (rs1073123) variant met the criteria for further analysis in testing and validation sets each containing 183 patients. The median PFS for the 366 patients was 4.9 months. Fifty-three patients (14.5%) had the TSC1 (Met322Thr or Thr322Thr) variant. TSC1 Met322Thr associated with longer PFS in the testing set (HR adjusted for age, gender, smoking habits, Eastern Cooperative Oncology Group performance status, histology, and stage [aHR] and 95% CI: 0.63 and 0.45–0.87, Cox P=0.009), and this was confirmed in the validation set (aHR and 95% CI: 0.58 and 0.36–0.93, Cox P=0.004). However, no association was found between the TSC1 gene variant and OS. These findings suggest that the TSC1 gene variant is an important predictive marker for platinum doublet chemotherapy outcomes in NSCLC patients.
Non‐alternating stochastic K‐means based on probabilistic representation of solution space
Authors: Lee M.
Published: March 2019

A non‐alternating (NA) form of K‐means is proposed to improve the performance for the most fundamental, yet highly non‐convex clustering problem. The motivation of this Letter is that the non‐convex nature of K‐means can be better handled by stochastic optimisation. However, the alternating update of the Lloyd's algorithm prohibits an effective stochastic optimisation. In order to fully realise the idea, a probabilistic representation is provided for the solution space of K‐means, which leads to a simple yet efficient NA update. Experiments show that the proposed method outperforms the existing variants, especially for large numbers of clusters, with reasonable time complexity.
Structured behaviour prediction of on‐road vehicles via deep forest
Authors: Mou Luntian , Mao Shasha , Xie Haitao , Chen Yanyan
Published: March 2019

Vision‐based vehicle behaviour analysis has drawn increasing research efforts as an interesting and challenging issue in recent years. Although a variety of approaches have been taken to characterise on‐road behaviour, there still lacks a general model for interpreting the behaviour of vehicles on the road. In this Letter, the authors propose a new method that effectively predicts the vehicle behaviour based on structured deep forest modelling. Inspired by structured learning, the structure information of vehicle behaviour is extracted from the detected vehicle, and then the corresponding structured label is constructed. Especially, the structured label visually expresses the vehicle behaviour as contrast to the discrete numerical label. With the structured label, a structured deep forest model is proposed to predict the vehicle behaviour. Experimental results illustrate that the proposed method successfully obtains the implication of semantic interpretation of vehicle behaviour by the predicted structured labels, and meanwhile it achieves comparable performance with traditional methods.
Venus Express radio occultation observed by PRIDE
Authors: Bocanegra-Bahamón T. M. , Molera Calvés G. , Gurvits L. I. , Cimò G. , Dirkx D. , Duev D. A. , Pogrebenko S. V. , Rosenblatt P. , Limaye S. , Cui L. , Li P. , Kondo T. , Sekido M. , Mikhailov A. G. , Kharinov M. A. , Ipatov A. V. , Wang W. , Zheng W. , Ma M. , Lovell J. E. J. , McCallum J. N.
Published: March 2019

Context. Radio occultation is a technique used to study planetary atmospheres by means of the refraction and absorption of a spacecraft carrier signal through the atmosphere of the celestial body of interest, as detected from a ground station on Earth. This technique is usually employed by the deep space tracking and communication facilities (e.g., NASA’s Deep Space Network (DSN), ESA’s Estrack).

Aims. We want to characterize the capabilities of the Planetary Radio Interferometry and Doppler Experiment (PRIDE) technique for radio occultation experiments, using radio telescopes equipped with Very Long Baseline Interferometry (VLBI) instrumentation.

Methods. We conducted a test with ESA’s Venus Express (VEX), to evaluate the performance of the PRIDE technique for this particular application. We explain in detail the data processing pipeline of radio occultation experiments with PRIDE, based on the collection of so-called open-loop Doppler data with VLBI stations, and perform an error propagation analysis of the technique.

Results. With the VEX test case and the corresponding error analysis, we have demonstrated that the PRIDE setup and processing pipeline is suited for radio occultation experiments of planetary bodies. The noise budget of the open-loop Doppler data collected with PRIDE indicated that the uncertainties in the derived density and temperature profiles remain within the range of uncertainties reported in previous Venus’ studies. Open-loop Doppler data can probe deeper layers of thick atmospheres, such as that of Venus, when compared to closed-loop Doppler data. Furthermore, PRIDE through the VLBI networks around the world, provides a wide coverage and range of large antenna dishes, that can be used for this type of experiments.
Stellar and substellar companions of nearby stars from Gaia DR2
Authors: Kervella Pierre , Arenou Frédéric , Mignard François , Thévenin Frédéric
Published: March 2019

Context. The census of stellar and substellar companions of nearby stars is largely incomplete, in particular toward the low-mass brown dwarf and long-period exoplanets. It is, however, fundamentally important in the understanding of the stellar and planetary formation and evolution mechanisms. Nearby stars are particularly favorable targets for high precision astrometry.

Aims. We aim to characterize the presence of physical companions of stellar and substellar mass in orbit around nearby stars.

Methods. Orbiting secondary bodies influence the proper motion of their parent star through their gravitational reflex motion. Using the HIPPARCOS and Gaia’s second data release (GDR2) catalogs, we determined the long-term proper motion of the stars common to these two catalogs. We then searched for a proper motion anomaly (PMa) between the long-term proper motion vector and the GDR2 (or HIPPARCOS) measurements, indicative of the presence of a perturbing secondary object. We focussed our analysis on the 6741 nearby stars located within 50 pc, and we also present a catalog of the PMa for ≳99% of the HIPPARCOS catalog (≈117 000 stars).

Results. 30% of the stars studied present a PMa greater than 3σ. The PMa allows us to detect orbiting companions, or set stringent limits on their presence. We present a few illustrations of the PMa analysis to interesting targets. We set upper limits of 0.1−0.3 MJ to potential planets orbiting Proxima between 1 and 10 au (Porb = 3 to 100 years). We confirm that Proxima is gravitationally bound to α Cen. We recover the masses of the known companions of ϵ Eri, ϵ Ind, Ross 614 and β Pic. We also detect the signature of a possible planet of a few Jovian masses orbiting τ Ceti.

Conclusions. Based on only 22 months of data, the GDR2 has limitations. But its combination with the HIPPARCOS catalog results in very high accuracy PMa vectors, that already enable us to set valuable constraints on the binarity of nearby objects. The detection of tangential velocity anomalies at a median accuracy of σ(ΔvT) = 1.0 m s−1 per parsec of distance is already possible with the GDR2. This type of analysis opens the possibility to identify long period orbital companions otherwise inaccessible. For long orbital periods, Gaia’s complementarity to radial velocity and transit techniques (that are more sensitive to short orbital periods) already appears to be remarkably powerful.
Controllability of low Reynolds numbers swimmers of ciliate type
Authors: Lohéac Jérôme , Takahashi Takéo
Published: March 2019

We study the locomotion of a ciliated microorganism in a viscous incompressible fluid. We use the Blake ciliated model: the swimmer is a rigid body with tangential displacements at its boundary that allow it to propel in a Stokes fluid. This can be seen as a control problem: using periodical displacements, is it possible to reach a given position and a given orientation? We are interested in the minimal dimension d of the space of controls that allows the microorganism to swim. Our main result states the exact controllability with d = 3 generically with respect to the shape of the swimmer and with respect to the vector fields generating the tangential displacements. The proof is based on analyticity results and on the study of the particular case of a spheroidal swimmer.
MALDI-TOF mass spectrometry: a new tool for rapid identification of cercariae (Trematoda, Digenea)
Authors: Huguenin Antoine , Depaquit Jérôme , Villena Isabelle , Ferté Hubert
Published: March 2019

Identification of cercariae was long based on morphological and morphometric features, but these approaches remain difficult to implement and require skills that have now become rare. Molecular tools have become the reference even though they remain relatively time-consuming and expensive. We propose a new approach for the identification of cercariae using MALDI-TOF mass spectrometry. Snails of different genera (Radix, Lymnaea, Stagnicola, Planorbis, and Anisus) were collected in the field to perform emitting tests in the laboratory. The cercariae they emitted (Trichobilharzia anseri, Diplostomum pseudospathaceum, Alaria alata, Echinostoma revolutum, Petasiger phalacrocoracis, Tylodelphys sp., Australapatemon sp., Cotylurus sp., Posthodiplostomum sp., Parastrigea sp., Echinoparyphium sp. and Plagiorchis sp.) were characterized by sequencing the D2, ITS2 and ITS1 domains of rDNA, and by amplification using specific Alaria alata primers. A sample of each specimen, either fresh or stored in ethanol, was subjected to a simple preparation protocol for MALDI-TOF analysis. The main spectral profiles were analyzed by Hierarchical Clustering Analysis. Likewise, the haplotypes were analyzed using the maximum likelihood method. Analytical performance and the log-score value (LSV) cut-off for species identification were then assessed by blind testing. The clusters obtained by both techniques were congruent, allowing identification at a species level. MALDI-TOF enables identification at an LSV cut-off of 1.7 without false-positives; however, it requires more data on closely related species. The development of a “high throughput” identification system for all types of cercariae would be of considerable interest in epidemiological surveys of trematode infections.
„Palliative“ Psychotherapie?
Authors: Senf Wolfgang
Published: March 2019

In den Essentials in diesem Heft wird die palliative Psychotherapie neben anderen
psychotherapeutischen Ansätzen für Menschen am Lebensende aufgeführt. Dies weist
auf die Notwendigkeit hin, Psychotherapie – unabhängig von der jeweiligen
Grundorientierung – einer stärkeren Binnendifferenzierung zu unterziehen. Der
palliative Ansatz betrifft außerdem noch andere Problembereiche, die
psychotherapeutisch schwer oder nicht zu bewältigen sind.
Verwendung von Fotos in Werbematerial für die eigene Praxis
– Was muss ich beachten?
Authors: Bossenmayer Jörg
Published: March 2019

„Wer nicht wirbt, der stirbt!“ – diese alte unternehmerische „Weisheit“ gilt
auch für den Gesundheitsmarkt. Denn auch die Akteure auf dem
Gesundheitsmarkt sind darauf angewiesen, ihre Angebote bekannt zu machen und
über ihre Dienstleistungen zu informieren. Das Recht auf Werbung ist Teil
der Berufsausübungsfreiheit, die ein Grundrecht ist (Artikel 12 Absatz 1
Grundgesetz (GG)). Aber gerade im Gesundheitsbereich gibt es einige
Einschränkungen bezüglich der Werbefreiheit. Dieser Beitrag soll einen
Überblick verschaffen, was insbesondere bei der Verwendung von Bildern in
Werbematerial zu beachten ist.
Bei Trost Seelsorgliche Begleitung sterbender und
trauernder Menschen
Authors: Burgdörfer Ludwig
Published: March 2019

Die Sorge um die Seele ist die größte Herausforderung angesichts extremer
Lebenskrisen und Schwellenängste. Ihr Qualitätsmerkmal ist die
menschenfreundliche Begleitung zwischen Abstand und Nähe. Seelsorge agiert mit
dem Vorbehalt, keine letzten befriedigenden Lösungen oder Antworten zu haben.
Sie ist ehrlich im Ertragen von Rätseln und Zumutungen. Sie setzt eine
befreundete Beziehung zu der Tatsache voraus, dass neben dem Begreifen das
Loslassen die Königsdisziplin aller Herausforderungen des Lebens ist.
Bis zuletzt leben können – spezialisierte ambulante
Palliativversorgung (SAPV)
Authors: Becker-Annen Annette , Lander Klaus
Published: March 2019

Im Zentrum der palliativen Versorgung steht die Verbesserung der Lebensqualität,
nicht die Verlängerung der verbleibenden Lebenszeit der PatientInnen. Im
Mittelpunkt der Arbeit eines SAPV-Teams stehen die individuellen Bedürfnisse und
Wünsche der PatientInnen. Durch Unterstützung der PatientInnen und deren
Angehörigen soll es den Erkrankten ermöglicht werden, zuhause sterben zu
können.
Müssen wir alles psychotherapieren?
Authors: Broda Michael , Wilms Bettina
Published: March 2019

In der Regel werden Geburten weder psychotherapeutisch begleitet noch mit einer
F-Diagnose aus dem ICD-10 versehen. Sie werden als integraler Bestandteil des
Menschseins und somit des Lebens verstanden. Warum sollte dies am Lebensende anders
sein?
Checkpoint-Inhibitoren: Die neue Immuntherapie bei gastrointestinalen Karzinomen
Authors: Moehler Markus , Foerster Friedrich
Published: March 2019

Die Immuntherapie erfährt viel Aufmerksamkeit in der Krebsmedizin wegen beachtlicher therapeutischer Erfolge bei zahlreichen Tumorarten. Die zentrale Medikamentengruppe sind die Checkpoint-Inhibitoren (CI) – für ihre Entdeckung wurde 2018 der Nobelpreis für Medizin verliehen. Dieser Beitrag gibt einen Überblick über die bereits vorhandene Evidenz und den aktuellen Stellenwert von CI bei der Therapie gastrointestinaler Tumoren.
Entscheider-Blog: TSVG: Wer legt eigentlich die Standards für die Patientenakte fest?
Authors: Krohne Christian
Published: March 2019

Bei der zweiten Anhörung zum Terminservice- und Versorgungsgesetz (TSVG) war das Thema „Interoperabilität“ ein heiß diskutierter Punkt. Worum geht es? Die Kassenärztliche Bundesvereinigung (KBV) soll dabei die umfassende Verantwortung für die Interoperabilität elektronischer Patientenakten erhalten und dabei unter anderem festlegen, welche inhaltlichen und technischen Standards dafür gelten sollen. Zum Jahr 2021 ist die Einführung der elektronischen Patientenakte verpflichtend, die Zeit drängt also.
Viasalus-Insolvenz: Bangen im Westerwald
Authors: Kohrs Jens
Published: March 2019

Weil die Zahlungsunfähigkeit drohte, hat der Klinik- und Heimbetreiber ViaSalus in Dernbach Ende Januar überraschend Insolvenz angemeldet. Vier seiner fünf Krankenhäuser schreiben Miese. Kaufinteressenten stehen schon bereit – und 2 350 Mitarbeiter fürchten um ihre Jobs.
23. Symposium zum Gesundheitsmanagement: Regionaler Versorgungsbedarf: Wie Kliniken die richtige Strategie finden
Authors: Rumpel Ralf
Published: March 2019

Zu wenige Ärzte auf dem Land, zahlreiche Kliniken mit ähnlichen Angeboten in Ballungsgebieten. Die regionale Versorgungssituation stellt eine zentrale Herausforderung für die Positionierung von Kliniken dar. Am 4. April 2019 greift das 23. Symposium zum Gesundheitsmanagement dieses hochaktuelle Thema auf. Darüber sprachen wir auch mit Veranstalter Prof. Dr. Michael Lingenfelder von der Phillips Universität Marburg.
Digitale Pathologie: „Schnellere, zuverlässigere und reproduzierbarere Ergebnisse“
Authors: Rößing Sabine
Published: March 2019

Die digitale Pathologie ist auf dem Vormarsch in deutschen Krankenhäusern. Der Ersatz der konventionellen Mikroskopie durch die Befundung am Computerbildschirm in Verbindung mit dem digitalen Datenmanagement verspricht zahlreiche Vorteile.
Ärztliche leistungen Delegieren? Guck mal, wer hier scannt
Authors: König Romy
Published: March 2019

Seit Jahren wird in Deutschland darüber debattiert, wer in Kliniken und Arztpraxen Ultraschalluntersuchungen durchführen darf. Fachverbände sperren sich dagegen, die Leistung an nicht-ärztliches Personal zu delegieren, wie es im Ausland üblich ist. Jetzt nimmt die Diskussion an Schärfe zu.
Das vernetzte Patientenbett: Wie man sich bettet, so liegt man
Authors: Glied Karsten
Published: March 2019

Schon die Herkunft des Begriffs „Klinik“ – altgriechisch klinē „Bett“ – legt nahe, dass die Liegefläche Mittelpunkt vieler Patienten ist und gleichzeitig zum Arbeitsplatz von Pflegern und Ärzten gehört. Digital vernetzte Patientenbetten können Daten erfassen und verarbeiten. Das erleichtert etwa die Koordination von Kontrollbesuchen, das Abrufen des Patientenzustandes und rechtzeitiges Eingreifen in Notsituationen.
Healing Architecture: Wenn Architekten Ärzten helfen
Authors: Kohrs Jens
Published: March 2019

Wie die Architektur eines Krankenhauses die Genesung von Patienten unterstützen kann, beschäftigt auch deutsche Klinikplaner zunehmend. Im Interview erklärt die Münchner Architektin Prof. Christine Nickl-Weller, was genau hinter dem Konzept der Healing Architecture steckt.
Effect of Homeopathic Medicines and a Nosode on Larvae of Cochliomyia hominivorax (Diptera: Calliphoridae)
Authors: de Barros Giuliano Pereira , Seugling Jaqueline , Bricarello Patrizia Ana
Published: March 2019

Background Cochliomyia hominivorax is the major fly causing primary myiasis in livestock animals in Brazil; its larvae develop in the host's living tissues, causing mutilations, which can even lead to death. In conventional treatments of myiasis, chemo-synthetic insecticides have been employed directly on larvae present in the wounds. Homeopathy may represent a healthy and sustainable alternative both to prevent and to treat myiasis in animals and humans. The current study evaluated how the emergence of adult insects is affected by the use of the homeopathic medicines Sulfur 12cH and Pyrogenium 12cH, and the nosode produced from C. hominivorax larvae at potencies 8cH and 12cH, on third-stage larvae of a C. hominivorax colony.

Materials and Methods The homeopathic medicines and the nosodes were produced according to the Brazilian Homeopathic Pharmacopoeia. Control groups were distilled water, alcohol, no substance, and the organophosphate insecticide trichlorfon. For each group, 10 replicates were performed. Emergence rate of adult insects was evaluated by descriptive statistics followed by analysis of variance. Homogeneity of variances was verified by F-test and group means were compared with Tukey's test.

Results Mortality rates in control groups were 2.7% for 30% (v/v) alcohol, 4.3% for distilled water, 3.2% for no substance (p > 0.05). In the trichlorfon group, the mortality rate of larvae was 90.8%. For Sulfur 12cH, the mortality of larvae was 94.6%, and for Pyrogenium 12cH it was 98.6%. The latter three means were not statistically different from each other or from the mean found for the trichlorfon group. The mortality rates of larvae were 61.3% and 66.6% for nosode C. hominivorax 8cH and 12cH, respectively (p > 0.05).

Conclusions Results suggest that homeopathy could be used therapeutically to prevent and treat animals and humans with myiasis caused by C. hominivorax.
On modules for meromorphic open-string vertex algebras
Authors: Qi Fei
Published: March 2019

We study modules of the meromorphic open-string vertex algebra (MOSVAs hereafter), a noncommutative generalization of vertex (operator) algebra defined by Yi-Zhi Huang. We start by recalling the definition of a MOSVA V and left V-modules given in Huang’s paper. Then we define right V-modules and V-bimodules that reflect the noncommutative nature of V. When V satisfies a condition on the order of poles of the correlation function (which we call pole-order condition), we prove that the rationality of products of two vertex operators implies the rationality of products of any numbers of vertex operators. Also, the rationality of iterates of any numbers of vertex operators is established and is used to construct the opposite MOSVA Vop of V. It is proved here that right (respectively, left) V-modules are equivalent to left (respectively, right) Vop-modules. Using this equivalence, we prove that if V and a grading-restricted left V-module W are endowed with a Möbius structure, then the graded dual W′ of W is a right V-module. This is the only proof in this paper that needs the grading-restriction condition. Also, this result is generalized to not-grading-restricted modules under a strong pole-order condition that is satisfied by all existing examples of MOSVAs and modules.
Thermodynamics and multiferroicity in PbTiO3 due to 4/5d electrons doping
Authors: Nazir S. , Tariq A.
Published: March 2019

Coexistence of ferromagnetism (FM) and spontaneous ferroelectric polarization (SP) is of great interest from both a fundamental and technological applications point of view in spintronic and high-density data storage devices. Here, we systematically investigated the possibility of FM and SP together in the PbTi87.5X12.5O3 (X=Zr, Nb, Mo, Hf, Ta, and W) systems by means of density functional theory calculations. Energetic stability of the doped systems is analyzed under appropriate thermodynamic conditions. We found that doped systems can be formed spontaneously at 0 K under Ti-poor and oxygen-poor/rich conditions. All the doped systems exhibit metallicity with a reasonable charge carrier density (∼1021 cm−3) and SP magnitude, except Zr and Hf due to the same valence as that of Ti. The microscopic origin of the conductivity in these doped structures is the charge distribution of extra electrons provided by Nb, Mo, Ta, and W dopants when doped at the Ti site. Interestingly, our calculations reveal that Mo and W doped PbTiO3 (PTO) systems show magnetism, which, further, strongly react with the on-site Coulomb repulsion (U), and the W@Ti doped system becomes half-metallic (one channel is a conductor and other is an insulator) FM. Moreover, the Ta-doped PTO system also shows a propensity to magnetism with the implementation of U. It is our belief that these findings open a new simple route to achieve multiferroics in perovskites and other related ferroelectric materials via 4/5d dopants.
Analysis on one-off subsidy for renewable energy projects based on time value of money
Authors: Yang Dongxiao , Jiang Minxing , Chen Ziyue , Nie Puyan
Published: March 2019

Due to the incentive policies of governments, renewable energy plays an increasingly important role in the global energy supply system. Among the subsidy schemes, the one-off subsidy is mainly applied in the projects with a long investment period where the time value of money cannot be ignored due to the long payback period. In this article, a microeconomic model of enterprises with a discount factor is established. The impact of the one-off subsidy by the government is discussed in different periods. The results show that only when the investment period is long enough, the government would give the enterprise one-off subsidy and the given subsidy is positively correlated with the investment period. Besides, the enterprise is more willing to invest in the project when getting close to the end of the investment period and the subsidy increases with the growth of capital-output elasticity. This article analyzes the optimal period of giving the one-off subsidy under the condition of different internal rates of return (IRRs). Based on the extended framework of subsidy analysis by game theory, it is found that if IRR of the enterprise is larger than that of the government, the subsidy is suggested to be given at the beginning of the project.
Germanium doping of cubic GaN grown by molecular beam epitaxy
Authors: Deppe M. , Gerlach J. W. , Shvarkov S. , Rogalla D. , Becker H.-W. , Reuter D. , As D. J.
Published: March 2019

We present a study of germanium as an alternative to silicon for n-type doping of cubic GaN. We find that Ge is a well-suited donor impurity. Our layers were grown by plasma-assisted molecular beam epitaxy on 3C-SiC/Si (001) substrates. Germanium-doped layers were fabricated with donor concentrations ranging over several orders of magnitude up to 3.7 × 1020 cm−3. For comparison, silicon-doped layers with donor concentrations of up to 3.8 × 1019 cm−3 were also grown. Incorporation of germanium into the cubic GaN layers was verified by time-of-flight secondary ion mass spectrometry. The crystalline quality of our layers was analyzed using high-resolution x-ray diffraction. Germanium- as well as silicon-doped layers with donor concentrations above 1019 cm−3 exhibited an increase of the dislocation density with increasing dopant concentration. The surface topography of our layers was investigated by atomic force microscopy. Comparable values for the surface roughness were measured for germanium- as well as silicon-doped layers. Optical properties were investigated by photoluminescence spectroscopy at 13 K. Doping with silicon resulted in a spectrally slightly narrower luminescence than doping with germanium. Donor concentrations and carrier mobilities were determined by Hall effect measurements at room temperature and we observe 20% higher electron mobilities for Ge-doping compared to Si-doping in the case of high dopant concentrations.
Unraveling the diverse nature of electric field induced spatial pattern formation in Gray-Scott model
Authors: Giri Amitava , Kar Sandip
Published: March 2019

We have considered a Gray-Scott kind of model chemical reaction-diffusion system that comprises ionic reactants and auto-catalysts to investigate the possibilities of mobility induced spatial pattern formation under the influence of an external electric field. Our study reveals that applying a uni-directional electric field can deform the already existing Turing patterns obtained due to diffusion driven instability, but cannot produce mobility driven instability and consequent spatial patterns in the absence of diffusion driven instability for a Gray-Scott like system. However, application of the electric field along two mutually perpendicular directions produces a mobility induced pattern in the absence of any differences in the diffusivities of the corresponding chemical reactants. Additionally, we have shown a systematic way to predict the range of absolute values of the pair of electric field intensities along two directions that will lead to spatially heterogeneous patterns in the absence of diffusion driven instability. Our study further demonstrates that the stability of the patterns formed and the nature of the patterns evolved varies with the increasing level of electric field intensities. The insights gained from this study will allow us to develop future experimental strategies to produce diverse range of stable and unique spatial patterns.
On reversals in 2D turbulent Rayleigh-Bénard convection: Insights from embedding theory and comparison with proper orthogonal decomposition analysis
Authors: Faranda D. , Podvin B. , Sergent A.
Published: March 2019

Turbulent Rayleigh-Bénard convection in a 2D square cell is characterized by the existence of a large-scale circulation which varies intermittently. We focus on a range of Rayleigh numbers where the large-scale circulation experiences rapid non-trivial reversals from one quasi-steady (or meta-stable) state to another. In previous work [B. Podvin and A. Sergent, J. Fluid Mech. 766, 172201 (2015); B. Podvin and A. Sergent, Phys. Rev. E 95, 013112 (2017)], we applied proper orthogonal decomposition (POD) to the joint temperature and velocity fields at a given Rayleigh number, and the dynamics of the flow were characterized in a multi-dimensional POD space. Here, we show that several of those findings, which required extensive data processing over a wide range of both spatial and temporal scales, can be reproduced, and possibly extended, by application of the embedding theory to a single time series of the global angular momentum, which is equivalent here to the most energetic POD mode. Specifically, the embedding theory confirms that the switches among meta-stable states are uncorrelated. It also shows that, despite the large number of degrees of freedom of the turbulent Rayleigh Bénard flow, a low dimensional description of its physics can be derived with low computational efforts, providing that a single global observable reflecting the symmetry of the system is identified. A strong connection between the local stability properties of the reconstructed attractor and the characteristics of the reversals can also be established.