bluuebunny/crossref_metadata_2025 huggingface dataset:
Mitochondria and Calcium Homeostasis: Cisd2 as a Big Player in Cardiac Ageing
Authors: Yeh Chi-Hsiao , Chou Yi-Ju , Kao Cheng-Heng , Tsai Ting-Fen
Published: December 2020

The ageing of human populations has become a problem throughout the world. In this context, increasing the healthy lifespan of individuals has become an important target for medical research and governments. Cardiac disease remains the leading cause of morbidity and mortality in ageing populations and results in significant increases in healthcare costs. Although clinical and basic research have revealed many novel insights into the pathways that drive heart failure, the molecular mechanisms underlying cardiac ageing and age-related cardiac dysfunction are still not fully understood. In this review we summarize the most updated publications and discuss the central components that drive cardiac ageing. The following characters of mitochondria-related dysfunction have been identified during cardiac ageing: (a) disruption of the integrity of mitochondria-associated membrane (MAM) contact sites; (b) dysregulation of energy metabolism and dynamic flexibility; (c) dyshomeostasis of Ca2+ control; (d) disturbance to mitochondria–lysosomal crosstalk. Furthermore, Cisd2, a pro-longevity gene, is known to be mainly located in the endoplasmic reticulum (ER), mitochondria, and MAM. The expression level of Cisd2 decreases during cardiac ageing. Remarkably, a high level of Cisd2 delays cardiac ageing and ameliorates age-related cardiac dysfunction; this occurs by maintaining correct regulation of energy metabolism and allowing dynamic control of metabolic flexibility. Together, our previous studies and new evidence provided here highlight Cisd2 as a novel target for developing therapies to promote healthy ageing
Ecological Restoration Plasters and Mineral Pigments Designed with Raw Material from the Island of Gavdos
Authors: Fotiou Afroditi , Oiry Claire , Kapetanaki Kali , Perdikatsis Vassilis , Kallithrakas-Kontos Nikolaos , Maravelaki Pagona-Noni
Published: December 2020

Gavdos is an island of ca. 34 km2 located to the south of Crete, Greece, with a local landscape rich in clay material of remarkable diversity in colour and quality. The limited natural and human-made resources are persistently recycled, forming the built structures of the island and determining the island’s sustainable local tradition. In the framework of this research, areas with clay soil were identified through a geological survey and testimonies of local inhabitants. The studied clay samples were characterized with mineralogical and physicochemical analyses. Two out of ten samples with a clay content higher than 50%, after low-temperature thermal treatment (600 °C and 700 °C), functioned as pozzolanic additives enhancing the performance in resistance to salt decay and plasticity of lime mortars. Seven raw clay samples were used as pigments in lime-based colours and their performance and durability, as assessed with the appropriate laboratory analyses, revealed the existence of stable mineral pigments under UV and visible light irradiation. There is great potential in the exploitation of local raw material from the island of Gavdos for the restoration of the traditional building stock on the island in terms of resource efficiency, environmental impact and preservation of the local identity.
Re-Visiting the Incidence of Environmental Factors on a Pre-Imaginal Population of the Red Gum Lerp Psyllid, Glycaspis brimblecombei Moore
Authors: Junk Jürgen , Eickermann Michael , Milenovic Milan , Suma Pompeo , Rapisarda Carmelo
Published: December 2020

The red gum lerp psyllid, Glycaspis brimblecombei Moore (Hemiptera: Aphalaridae), is an invasive pest of Eucalyptus trees worldwide, responsible for serious damage, including the death of plants. Knowledge about the incidence of climatic factors on the insect development are essential to define useful strategies for controlling this pest. To this aim, G. brimblecombei has been sampled by two different methods from April 2012 to February 2013 in eastern Sicily on Eucalyptus camaldulensis in nine different sites, where the main climatic data (air temperature, relative humidity, and precipitation) have been also registered. The Glycaspis brimblecombei population showed a similar trend in all nine sites, positively correlated only with air temperature, but a negative correlation has emerged with precipitation and relative humidity. The results show the need for a deeper understanding of the role played by other abiotic (such as different concentrations of CO2) and biotic (e.g., the antagonistic action of natural enemies, competition with other pests, etc.) factors. The greater sensitivity, even at low densities of psyllid, of sampling methods based on the random collection of a fixed number of leaves compared to methods based on the collection of infested leaves in a fixed time interval has been also outlined.
Microgeographic Wing-Shape Variation in Aedes albopictus and Aedes scapularis (Diptera: Culicidae) Populations
Authors: Oliveira-Christe Rafael , Wilke André Barretto Bruno , Marrelli Mauro Toledo
Published: December 2020

Aedes albopictus and Aedes scapularis are vectors of several arboviruses, including the dengue, chikungunya, and Rocio virus infection. While Ae. albopictus is a highly invasive species native to Asia and has been dispersed by humans to most parts of the world, Ae. scapularis is native to Brazil and is widely distributed in the southeast of the country. Both species are highly anthropophilic and are often abundant in places with high human population densities. Because of the great epidemiological importance of these two mosquitoes and the paucity of knowledge on how they have adapted to different urban built environments, we investigated the microgeographic population structure of these vector species in the city of São Paulo, Brazil, using wing geometric morphometrics. Females of Ae. albopictus and Ae. scapularis were collected in seven urban parks in the city. The right wings of the specimens were removed and digitized, and eighteen landmarks based on vein intersections in the wing venation patterns were used to assess cross-sectional variation in wing shape and size. The analyses revealed distinct results for Ae. albopictus and Ae. scapularis populations. While the former had less wing shape variation, the latter had more heterogeneity, indicating a higher degree of intraspecific variation. Our results indicate that microgeographic selective pressures exerted by different urban built environments have a distinct effect on wing shape patterns in the populations of these two mosquito species studied here.
Inflammatory Proteins and Clinical Response to Psychological Therapy in Patients with Depression: An Exploratory Study
Authors: Strawbridge Rebecca , Marwood Lindsey , King Sinead , Young Allan H. , Pariante Carmine M. , Colasanti Alessandro , Cleare Anthony J.
Published: December 2020

In people with depression, immune dysfunctions have been linked with treatment non-response, but examinations of psychological therapy outcomes, particularly longitudinal biomarker studies, are rare. This study investigated relationships between inflammation, depressive subtypes and clinical outcomes to psychological therapy. Adults with depression (n = 96) were assessed before and after a course of naturalistically-delivered psychological therapy. In total, 32 serum inflammatory proteins were examined alongside therapy outcomes and depressive subtypes (somatic/cognitive symptom subtype, and bipolar/unipolar depression). Overall, 49% of participants responded to treatment. High levels of tumour necrosis factor (TNFα), interleukin-6 (IL-6) and soluble intracellular adhesion molecule-1 (sICAM1), and low interferon-γ (IFNγ), preceded a poorer response to therapy. After therapy, non-responders had elevated c-reactive protein (CRP), thymus and activation-regulated chemokine (TARC) and macrophage chemoattractant protein-4 (MCP4), and attenuated IFNy. Non-somatic depressive symptoms were universally not associated with proteins, while somatic-depressive symptom severity was positively correlated with several pro-inflammatory markers. In the somatic subgroup only, IL-6 and serum amyloid alpha (SAA) decreased between pre- and post-therapy timepoints. Regardless of treatment response, IL-7, IL-8, IL-15 and IL-17 increased over time. These results suggest that inflammation is associated with somatic symptoms of depression and non-response to psychological therapy. Future work may enhance the prospective prediction of treatment-response by examining larger samples of individuals undertaking standardised treatment programmes.
Cross-Layer Reliability, Energy Efficiency, and Performance Optimization of Near-Threshold Data Paths
Authors: Tahoori Mehdi , Golanbari Mohammad Saber
Published: December 2020

Modern electronic devices are an indispensable part of our everyday life. A major enabler for such integration is the exponential increase of the computation capabilities as well as the drastic improvement in the energy efficiency over the last 50 years, commonly known as Moore’s law. In this regard, the demand for energy-efficient digital circuits, especially for application domains such as the Internet of Things (IoT), has faced an enormous growth. Since the power consumption of a circuit highly depends on the supply voltage, aggressive supply voltage scaling to the near-threshold voltage region, also known as Near-Threshold Computing (NTC), is an effective way of increasing the energy efficiency of a circuit by an order of magnitude. However, NTC comes with specific challenges with respect to performance and reliability, which mandates new sets of design techniques to fully harness its potential. While techniques merely focused at one abstraction level, in particular circuit-level design, can have limited benefits, cross-layer approaches result in far better optimizations. This paper presents instruction multi-cycling and functional unit partitioning methods to improve energy efficiency and resiliency of functional units. The proposed methods significantly improve the circuit timing, and at the same time considerably limit leakage energy, by employing a combination of cross-layer techniques based on circuit redesign and code replacement techniques. Simulation results show that the proposed methods improve performance and energy efficiency of an Arithmetic Logic Unit by 19% and 43%, respectively. Furthermore, the improved performance of the optimized circuits can be traded to improving the reliability.
Indirect Effects of Grazing on Wind-Dispersed Elm Seeds in Sparse Woodlands of Northern China
Authors: Tang Yi , Liu Mingyu , Sun Zhanli
Published: December 2020

Grazing leads to the reduction of biomass and plays a critical role in land degradation in arid and semiarid lands. However, the indirect effects of grazing on the ecosystem, e.g., the effect on seed dispersal, have not been well understood. In this study, we built an agent-based model (ABM) to simulate how grazing intensity affects the seed dispersal of elm trees, one of the native vegetation species of temperate woodlands in semiarid lands. The simulated results from the ABM and observed data from the real world were compared to assess the accuracy and validity of the ABM. The results show that elm seed densities in non-grazing, light, moderate, and heavy grazing lands were 74.97 ± 1.44, 57.63 ± 0.89, 37.73 ± 0.95, and 0.97 ± 0.05 seeds m−2, respectively—an apparently decreasing trend. Moreover, as grazing intensity increased, the values of nugget, sill, and partial sill decreased and the value of the ratio of nugget to sill increased. This study indicates that the grazing indirectly leads to the reduction of elm seed density and the increase of spatial heterogeneity of elm seed on the ground in sparse elm woodlands. Moreover, values of geostatistical indices from the ABM were not significantly different from field observation data except for the ratio of nugget to sill. It shows that ABMs can reasonably replicate the spatial pattern of elm seed densities in the field and thus are useful for simulating long-distance seed dispersal in sandy lands. This finding suggests that the indirect effects of grazing should be considered to effectively protect sparse elm woodlands.
Efficacy of the Newly Invented Eyelid Clamper in Ultra-Widefield Fundus Imaging
Authors: Ozawa Nobuhiro , Mori Kiwako , Katada Yusaku , Tsubota Kazuo , Kurihara Toshihide
Published: December 2020

Background: Ultra-widefield fundus imaging is widely used for obtaining wide angle images of the retina in one single image. Although it has a potential to obtain a wide area of retinal photographs, images are often obstructed by eyelashes or eye lids. In this study, we used a newly invented eyelid clamper, which can keep an eye open without touching conjunctiva or lid margin, to assess the efficacy in clinical use by comparing with conventional tape fixation. Methods: Ultra-widefield fundus images were captured with an ultra-widefield imaging system in 19 patients who visited to the outpatient clinic of Department of Ophthalmology, Keio University Hospital with the eyelid clamper or a conventional tape fixation. The area of imaged retinas was outlined and quantified with pixels. After obtaining images, patients answered a questionnaire. Results: The average number of pixels in total areas with the eyelid clamper or with tape fixation were 4.31 ± 0.35 and 4.32 ± 0.34 mega pixels, respectively, showing no significant difference between the groups (p = 0.889). The average face pain scale of the eyelid clamper was 1.13 on a scale of 0 to 5. The number of patients who did not feel any pain was nine (47.4%). Conclusions: The eyelid clamper can be applied in clinical setting and can better support obtaining sufficiently wide fundus images compared to a conventional tape fixation.
Any Role of PIK3CA and PTEN Biomarkers in the Prognosis in Oral Squamous Cell Carcinoma?
Authors: Starzyńska Anna , Adamska Paulina , Sejda Aleksandra , Sakowicz-Burkiewicz Monika , Adamski Łukasz Jan , Marvaso Giulia , Wychowański Piotr , Jereczek-Fossa Barbara Alicja
Published: December 2020

Oral squamous cell carcinoma (OSCC) accounts for 95% of the lesions in the oral cavity. Despite development in OSCC management, the outcome is still unsatisfactory. Identification of new therapies in OSCC is urgently needed. One objective of such treatment may be a signaling pathway of phosphatidylinositol 3-kinase. The study group included 92 patients treated for OSCC at the University Clinical Centre in Gdańsk, Poland. Study was performed on formalin-fixed paraffin-embedded samples from primary OSCC. Phosphatidylinositol-4,5-bisphosphate 3-kinase (PIK3CA) and phosphatase and tensin homolog encoded on chromosome 10 (PTEN) protein expression was assessed by immunohistochemistry (IHC). PIK3CA gene copy number was analyzed using chromogenic and silver in situ hybridization where molecular probes are marked by chromogens and silver ions. PIK3CA IHC H-score ≥ 70 was found in 51.65% patients, and loss of PTEN protein was noticed in 31.46% cases. PIK3CA amplification was detected in 5 tumors. In the case of PTEN protein expression, there was an inverse correlation with the T stage of the primary tumor (r = −0.243) and positive correlation with a 5-year survival (r = 0.235). The number of copies of the PIK3CA gene was associated with the tumor grading (r = 0.208). The present study shows that loss of PTEN protein and the grading (p = 0.040), distant metastases (p = 0.033), smoking (p = 0.016), and alcohol abuse (p = 0.042) were prognostic factors for the survival of patients with OSCC. In contrast, the presence of amplification and OSCC on the floor of the mouth resulted in a nearly six-fold increase in the risk of shortening survival (p = 0.037). Our finding suggests a potential prognostic significance of PTEN loss and PIK3CA amplification in OSCC. Future studies are needed to confirm our results.
Numerical Methodology for Determining the Energy Losses in Auxiliary Systems and Friction Processes Applied to Low Displacement Diesel Engines
Authors: Abril Sofia Orjuela , Piero Rojas Jhan , Flórez Eder Norberto
Published: December 2020

The problem of climate change and the reduction of fossil fuels has motivated the development of research focused on improving the efficiency of internal combustion engines. This research proposes a methodology based on mathematical models to determine the energy losses caused by auxiliary systems and friction processes in the engine. Therefore, models are proposed for calculating the energy losses in fuel injection, lubrication, and cooling system. In the same way, models are proposed for the energy losses due to friction in the piston, valve train, and bearings. Experimental tests are carried out on a single-cylinder diesel engine under different operating conditions to validate the proposed models. The results showed that the energy losses of the fuel injection, lubrication, and coolant system are equal to 0.61%, 0.30%, and 0.31% of the chemical energy of the injected fuel. In the case of the energy losses by friction processes, the piston, valve train, and bearings represent 5.47%, 1.34%, and 1.85% of the fuel energy, respectively. Additionally, the proposed model allows estimating the minimum lubrication film present in the piston, valve train, and bearings, which in the particular case of the present study were 0.63 µm, 0.10 µm, and 0.57 µm, respectively. In general, the methodology developed in the present work stands as a robust tool to evaluate the modifications and/or designs of auxiliary systems and friction processes to reduce the energy losses and protect the system from wear caused by lubrication problems. Additionally, the methodology allows evaluating the effect of different types of fuels on the lubrication conditions of the piston and the crankshaft bearings.
Effect of Absorptivity of Superabsorbent Polymers on Design of Cement Mortars
Authors: Fořt Jan , Migas Przemysław , Černý Robert
Published: December 2020

The functional properties of composites modified by superabsorbent polymers (SAPs) strongly depend on the swelling capacity of applied SAPs. In this sense, three types of commercially available SAPs namely Cablock CT, Hydropam, and Creasorb SIS with different chemical composition and particle size distribution were studied in this manuscript to reveal the differences in absorptivity as can be viewed as pretests for their utilization in concrete composites. In addition, absorptivity in distilled water, tap water, and 0.1 M NaCl solution are examined for determining the SAPs response for the change of the solution pH. To overcome problems with the teabag method inaccuracy, the new method is introduced. Besides to quantitative evaluation of the SAPs absorptivity, the correlation for the absorption and desorption period as the function of SAPs residence time within the examined solution is proposed. To access the effect of selected SAPs on functional properties, optimization based on the flow table test is employed and mechanical parameters are determined after 7, 14, 28, and 90 days of curing. Obtained results refer to substantial differences between particular SAPs and contribute to the understanding of the effect of SAP on the functional properties of cement-based materials.
Treatment of Water Contaminated with Reactive Black-5 Dye by Carbon Nanotubes
Authors: De Luca Pierantonio , B. Nagy Jànos
Published: December 2020

Most of the dyes used today by the textile industry are of synthetic origin. These substances, many of which are highly toxic, are in many cases not adequately filtered during the processing stages, ending up in groundwater and water courses. The aim of this work was to optimize the adsorption process of carbon nanotubes to remove an azo-dye, called Reactive Black-5, from aqueous systems. Particular systems containing carbon nanotubes and dye solutions were analyzed. Furthermore, the reversibility of the process and the presence of possible degradation phenomena by the dye molecules were investigated. For this purpose, the influence of different parameters on the adsorption process, such as the nature of the carbon nanotubes (purified and nonpurified), initial concentration of the dye, stirring speed, and contact times, were studied. The solid and liquid phases after the tests were characterized by chemical-physical techniques such as thermogravimetric analysis (TG, DTA), UV spectrophotometry, BET (Brunauer, Emmett, Teller), and TOC (total organic carbon) analysis. The data obtained showed a high adsorbing capacity of carbon nanotubes in the removal of the Reactive Black-5 dye from aqueous systems. Furthermore, the efficiency of the adsorption process was observed to be influenced by the stirring speed of the samples and the contact time, while purified and nonpurified nanotubes provided substantially the same results.
Methods of Protecting Buildings against HPM Radiation—A Review of Materials Absorbing the Energy of Electromagnetic Waves
Authors: Majcher Krzysztof , Musiał Michał , Pakos Wojciech , Różański Adrian , Sobótka Maciej , Trapko Tomasz
Published: December 2020

The pulsed high power microwave (HPM) technology has been developed worldwide for over 20 years. The sources of HPM pulses are a weapon of mass destruction. They pose danger especially to computer and telecommunications equipment and systems, both the military and civilian ones. This paper presents a survey of literature on electromagnetic wave radiation absorbing and shielding materials to be used in construction. Relevant protective measures should include the shielding of buildings or their parts and the absorption of radiation by building envelopes and their elements. The main focus is on the possibilities of improving the shielding and absorptive properties of common construction materials, such as concrete, mortars and synthetic resins. The survey covers the following groups of materials: carbon-based admixtures, nickel powder, iron powders, ferrites, magnetite and polymers. The final part of the survey is devoted to hybrid foam microwave absorbers in which the shape of the material’s inner structure and that of its surface play a special role.
Investigation of the Dendritic Structure Influence on the Electrical and Mechanical Properties Diversification of the Continuously Casted Copper Strand
Authors: Zasadzińska Małgorzata , Knych Tadeusz , Smyrak Beata , Strzępek Paweł
Published: December 2020

The properties of copper in its solid state are strongly affected by the crystallization conditions of the liquid material. ETP grade copper (Electrolytic Tough Pitch Copper) contains oxygen, which causes Cu2O oxide to crystallize in the interdendritic spaces during solidification process which due to the shape of continuous casting mould and the feed of liquid copper during the crystallization process in strand casting might cause a high risk of macrosegregation of oxygen in the copper structure. In the current paper the implied interactions of the dendritic structure of the copper strand in terms of homogeneity at the cross-section of its electrical, mechanical and plastic properties determined based on the samples taken parallelly and perpendicularly to the surface of the dendritic boundaries were analysed. The obtained results were confronted with scanning electron microscopy (SEM) images of the fractures formed during uniaxial tensile test. It has been observed that when the crystallites were arranged perpendicularly to the tensile direction the yield strength (YS) was lower and the fractures were brittle. On the other hand, when the crystallites were arranged parallelly to the tensile direction the fractures were plastic and elongated necking was observed along with the higher YS and total elongation values. The differences in values vary in terms of the applied direction of the tensile force. A characteristic positioning of the Cu2O oxide particles inside the fracture depending on the crystallite alignment and the direction of the applied tensile force has been observed.
New Grain Formation by Constitutional Undercooling Due to Remelting of Segregated Microstructures during Powder Bed Fusion
Authors: Rausch Alexander M. , Gotterbarm Martin R. , Pistor Julian , Markl Matthias , Körner Carolin
Published: December 2020

A microstructure has significant influence on the mechanical properties of parts. For isotropic properties, the formation of equiaxed microstructures by the nucleation of new grains during solidification is necessary. For conventional solidification processes, nucleation is well-understood. Regarding powder bed fusion, the repeated remelting of previous layers can cause nucleation under some conditions that are not explainable with classical theories. Here, we investigate this nucleation mechanism with an unprecedented level of detail. In the first step, we built samples with single crystalline microstructures from Ni-base superalloy IN718 by selective electron beam melting. In the second step, single lines with different parameters were molten on top of these samples. We observed a huge number of new grains by nucleation at the melt-pool border of these single lines. However, new grains can only prevail if the alignment of their crystallographic orientation with respect to the local temperature gradient is superior to that of the base material. The current hypothesis is that nucleation at the melt-pool border happens due to remelting microsegregations from former solidification processes leading to constitutional undercooling directly at the onset of solidification. This study offers the opportunity to understand and exploit this mechanism for different manufacturing processes.
Cellulose Modification for Improved Compatibility with the Polymer Matrix: Mechanical Characterization of the Composite Material
Authors: Cichosz Stefan , Masek Anna , Rylski Adam
Published: December 2020

The following article is the presentation attempt of cellulose hybrid chemical modification approach as a useful tool in improving the mechanical properties of plant fiber-filled polymer materials. The treatment process is a prolonged method of the cellulose maleinization and consists of two steps: 1. solvent exchange (altering fiber structure); 2. maleic anhydride (MA) chemical grafting (surface modification). Thanks to the incorporated treatment method, the created ethylene–norbornene copolymer composite specimen exhibited an improved performance, tensile strength at the level of (38.8 ± 0.8) MPa and (510 ± 20)% elongation at break, which is higher than for neat polymer matrix and could not be achieved in the case of regular MA treatment. Moreover, both the Payne effect and filler efficiency factor indicate a possibility of the fiber reinforcing nature that is not a common result. Additionally, the polymer matrix employed in this research is widely known for its excellent resistance to aqueous and polar organic media, good biocompatibility, and the ability to reproduce fine structures which makes it an interesting material regarding healthcare applications. Therefore, plant fiber-based polymer materials described in this research might be potentially applied in this area, e.g., medical devices, drug delivery, wearables, pharmaceutical blisters, and trays.
Mechanical Properties and Strength Reliability of Impregnated Wood after High Temperature Conditions
Authors: Przystupa Krzysztof , Pieniak Daniel , Samociuk Waldemar , Walczak Agata , Bartnik Grzegorz , Kamocka-Bronisz Renata , Sutuła Monika
Published: December 2020

The paper presents the results of the research into the impact of impregnation of wood on its bending strength and elastic modulus under normal conditions and after thermal treatment and investigates its structural reliability. Pinewood, non-impregnated and pressure impregnated with a solution with SiO2 nanoparticles, was used in this research. The use of nanoparticles decreases the flammability of timber among others. Some of the tested samples were treated at 250 °C. This temperature corresponds to the boundary of the self-ignition of wood. This elevated temperature was assumed to be reached by a given speed of heating within 10 min, and then the samples were stored in these conditions for 10 and 20 min. The tests demonstrate that the bending strength of the impregnated wood was slightly improved, the impregnation did not impact the elastic modulus of the material in all such conditions, and the residual strength decreased less for the wood impregnated after being exposed to the elevated temperatures. The reliability analysis proves a positive effect of impregnation with a solution with SiO2 on the durability of wood, both after being exposed to normal and elevated temperatures. The distribution of the failure rates indicates a more intensive degradation of non-impregnated wood. The distribution of the survival function demonstrates a more probable non-destruction of impregnated wood after elevated temperature conditions.
Effective and Apparent Diffusion Coefficients of Chloride Ions and Chloride Binding Kinetics Parameters in Mortars: Non-Stationary Diffusion–Reaction Model and the Inverse Problem
Authors: Jasielec Jerzy , Stec Jakub , Szyszkiewicz-Warzecha Krzysztof , Łagosz Artur , Deja Jan , Lewenstam Andrzej , Filipek Robert
Published: December 2020

A non-equilibrium diffusion–reaction model is proposed to describe chloride transport and binding in cementitious materials. A numerical solution for this non-linear transport with reaction problem is obtained using the finite element method. The effective chloride diffusion coefficients and parameters of the chloride binding are determined using the inverse method based on a diffusion–reaction model and experimentally measured chloride concentrations. The investigations are performed for two significantly different cements: ordinary Portland and blast furnace cements. The results are compared with the classical diffusion model and appropriate apparent diffusion coefficients. The role of chloride binding, with respect to the different binding isotherms applied, in the overall transport of chlorides is discussed, along with the applicability of the two models. The proposed work allows the determination of important parameters that influence the longevity of concrete structures. The developed methodology can be extended to include more ions, electrostatic interactions, and activity coefficients for even more accurate estimation of the longevity.
Study of Machining Process of SiCp/Al Particle Reinforced Metal Matrix Composite Using Finite Element Analysis and Experimental Verification
Authors: Laghari Rashid Ali , Li Jianguang , Wu Yongxiang
Published: December 2020

In this paper, a two-dimensional orthogonal cutting simulation model of SiCp/Al composite was established. The geometry and material constitutive model of the particle, the matrix, and the interface layer have been modeled respectively. In view of the distribution of the particles in the matrix, this paper proposed respectively a two-dimensional particle random distribution to simulate particles randomly distributed in the matrix. Then, the cutting state of SiC reinforced particles was analyzed, the novel approach was adopted the geometric shapes of SiC particles in this study is taken as an oval shape. Three different locations of SiC particle relative to the cutting tool path were simulated to analyze the cutting state such as particle removal. The interface layer was introduced to the case that the particle was on the cutting path to study the influence on the stress and strain transfer. Through the post-processing of simulation results, the influence of interface property on the composite reinforcement effect was studied quantificationally. Finally, the cutting process of SiCp/Al composite material was simulated. This paper studied the influence on the machined surface morphology, chip morphology, stress distribution, and cutting force of many factors of the cutting speed and the cutting thickness. The single factor orthogonal cutting experiment was designed the influence of cutting speed and feed rate on the cutting force. The cutting force results of the experiment and the simulation were compared through the deviation analysis, which verified the simulation model.
Achieving Ti-5Al-4Sn-2Zr-1Mo-0.25Si-1Nb Alloys with High Strength and Moderate Ductility through Selective Laser Melting
Authors: Ran Jiangtao , Sun Xiaojing , Wei Shiliang , Chen Zhuo , Zhao Hong
Published: December 2020

Ti-5Al-4Sn-2Zr-1Mo-0.25Si-1Nb (TA32) titanium alloy is a kind of near α high temperature titanium alloy with great application prospects in aero-engine afterburners and cruise missiles. However, there are still few studies on the microstructure and mechanical properties of TA32 specimens produced by selective laser melting (SLM) technology. In this study, TA32 specimens with high strength (tensile strength of 1267 MPa) and moderate ductility (elongation after fracture of 8%) were obtained by selective laser melting. The effect of laser power on the microstructure and mechanical behavior was studied and the results demonstrated that the average grain size increases with increasing laser power from 200 W to 400 W. Micro-zone composition analysis was carried out by energy dispersion spectrum (EDS), showing that the Al concentration inner grains is higher than that near grain boundaries. Fracture analysis results demonstrated that the fracture mode of SLM TA32 specimens was cleavage fracture. The tensile strength of the specimens built with a laser power of 250 W at 500 °C, 550 °C and 600 °C was measured as 869 MPa, 819 MPa and 712 MPa, respectively.
Effect of PVP Coating on LiMnBO3 Cathodes for Li-Ion Batteries
Authors: Hong Bolong , He Xiangming , Yi Huihua , Hu Chenglin
Published: December 2020

LiMnBO3 is a potential cathode for Li-ion batteries, but it suffers from a low electrochemical activity. To improve the electrochemical performance of LiMnBO3, the effect of polyvinyl pyrrolidone (PVP) as carbon additive was studied. Monoclinic LiMnBO3/C and LiMnBO3-MnO/C materials were obtained by a solid-state method at 500 °C. The structure, morphology and electrochemical behavior of these materials are characterized and compared. The results show that carbon additives and ball-milling dispersants affect the formation of impurities in the final products, but MnO is beneficial for the performance of LiMnBO3. The sample of LiMnBO3-MnO/C delivered a high capacity of 162.1 mAh g−1 because the synergistic effect of the MnO/C composite and the suppression of the PVP coating on particle growth facilitates charge transfer and lithium–ion diffusion.
Innovative Design and Fuzzy Logic Control for An Underground Moving Sieve Jig
Authors: Shang Deyong , Yang Zhiyuan , Wang Junjie , Wang Yuwei , Liu Yue
Published: December 2020

Underground gangue filling technology in coal mines is one of the effective ways to realize green mining. In this paper, a process of underground raw coal primary selection is proposed, which is based on a mechanical sieve jig as the main washing equipment. It refers to the structure of the ground mechanical moving sieve jig. It optimizes and improves the main structure of the jig machine’s driving mechanism and gangue discharge mechanism. It meets the requirements of the technology and the narrow space environment in the underground mine and realizes the effective separation of coal and gangue. In the jigging process of a moving sieve, it is very important to keep the jig bed stable and precisely control the quantity of gangue discharge for improving the system separation accuracy and efficiency. In this paper, a control method based on a fuzzy logic combination is proposed to realize the fuzzy logic control of the motor speed of gangue discharging, which aims at the nonlinear, time-varying uncertainty and pure lag characteristics of the control system of the underground moving sieve jig. Further industrial experiments were carried out and we obtained the variation law of the gangue’s quality in the moving sieve and the output curve of the gangue motor frequency under three working conditions. The experimental results show that the fuzzy logic control algorithm can quickly stabilize the jig bed in the vibrating sieve when the quantity of gangue changes abruptly or fluctuates greatly. It improves the separation efficiency of coal and gangue and effectively solves the problems of nonlinearity, time-varying and hysteresis in the control process of the moving sieve jig.
Progress in Research on Bioactive Secondary Metabolites from Deep-Sea Derived Microorganisms
Authors: Wang Ya-Nan , Meng Ling-Hong , Wang Bin-Gui
Published: December 2020

Deep sea has an extreme environment which leads to biodiversity of microorganisms and their unique physical and biochemical mechanisms. Deep-sea derived microorganisms are more likely to produce novel bioactive substances with special mechanism of action for drug discovery. This article reviews secondary metabolites with biological activities such as anti-tumor, anti-bacterial, anti-viral, and anti-inflammatory isolated from deep-sea fungi and bacteria during 2018–2020. Effective methods for screening and obtaining natural active compounds from deep-sea microorganisms are also summarized, including optimizing the culture conditions, using genome mining technology, biosynthesis and so on. The comprehensive application of these methods makes broader prospects for the development and application of deep sea microbial bioactive substances.
Correlation between the Porosity and Permeability of a Polymer Filter Fabricated via CO2-Assisted Polymer Compression
Authors: Aizawa Takafumi , Wakui Yoshito
Published: December 2020

A porous filter was fabricated by plasticizing polymer fibers with CO2, followed by pressing and adhering; then, its gas permeability, a basic physical property of filters, was measured using N2. The as-obtained filter was well compressed and expected to approximate a sintered porous material. Therefore, the fabricated filter was analyzed by applying the Darcy law, and the correlation between its gas permeability and porosity was clarified. The gas permeability decreased owing to both pore size and porosity reduction upon increasing the degree of compression, which is a feature of the CO2-assisted polymer compression method. In particular, without any contradiction of pore size data previously reported, the gas permeability was clearly determined by the filter porosity and pore size. This study can serve as a guide for designing filters via CO2-assisted polymer compression.
The Effect of Ca on In Vitro Behavior of Biodegradable Zn-Fe Alloy in Simulated Physiological Environments
Authors: Avior Orit , Ben Ghedalia-Peled Noa , Ron Tomer , Vago Razi , Aghion Eli
Published: December 2020

The growing interest in Zn based alloys as structural materials for biodegradable implants is mainly attributed to the excellent biocompatibility of Zn and its important role in many physiological reactions. In addition, Zn based implants do not tend to produce hydrogen gas in in vivo conditions and hence do not promote the danger of gas embolism. However, Zn based implants can provoke encapsulation processes that, practically, may isolate the implant from its surrounding media, which limits its capability of performing as an acceptable biodegradable material. To overcome this problem, previous research carried out by the authors has paved the way for the development of Zn-Fe based alloys that have a relatively increased corrosion rate compared to pure Zn. The present study aims to evaluate the effect of 0.3–1.6% Ca on the in vitro behavior of Zn-Fe alloys and thus to further address the encapsulation problem. The in vitro assessment included immersion tests and electrochemical analysis in terms of open circuit potential, potentiodynamic polarization, and impedance spectroscopy in phosphate buffered saline (PBS) solution at 37 °C. The mechanical properties of the examined alloys were evaluated by tension and hardness tests while cytotoxicity properties were examined using indirect cell metabolic activity analysis. The obtained results indicated that Ca additions increased the corrosion rate of Zn-Fe alloys and in parallel increased their strength and hardness. This was mainly attributed to the formation of a Ca-rich phase in the form CaZn13. Cytotoxicity assessment showed that the cells’ metabolic activity on the tested alloys was adequate at over 90%, which was comparable to the cells’ metabolic activity on an inert reference alloy Ti-6Al-4V.
Comparison between Virgin and Recycled 316L SS and AlSi10Mg Powders Used for Laser Powder Bed Fusion Additive Manufacturing
Authors: Mohd Yusuf Shahir , Choo Edmund , Gao Nong
Published: December 2020

In this study, the comparison of properties between fresh (virgin) and used (recycled) 316L stainless steel (316L SS) and AlSi10Mg powders for the laser powder bed fusion additive manufacturing (L-PBF AM) process has been investigated in detail. Scanning electron microscopy (SEM), electron-dispersive X-ray spectroscopy (EDX), and X-ray diffraction (XRD) techniques are used to determine and evaluate the evolution of morphology, particle size distribution (PSD), circularity, chemical composition, and phase (crystal structure) in the virgin and recycled powders of both materials. The results indicate that both recycled powders increase the average particle sizes and shift the PSD to higher values, compared with their virgin powders. The recycled 316L SS powder particles largely retain their spherical and near-spherical morphologies, whereas more irregularly shaped morphologies are observed for the recycled AlSi10Mg counterpart. The average circularity of recycled 316L SS powder only reduces by ~2%, but decreases ~17% for the recycled AlSi10Mg powder. EDX analysis confirms that both recycled powders retain their alloy-specific chemical compositions, but with increased oxygen content. XRD spectra peak analysis suggests that there are no phase change and no presence of any undesired precipitates in both recycled powders. Based on qualitative comparative analysis between the current results and from various available literature, the reuse of both recycled powders is acceptable up to 30 times, but re-evaluation through physical and chemical characterizations of the powders is advised, if they are to be subjected for further reuse.
Capsaicin and Gut Microbiota in Health and Disease
Authors: Rosca Adrian Eugen , Iesanu Mara Ioana , Zahiu Carmen Denise Mihaela , Voiculescu Suzana Elena , Paslaru Alexandru Catalin , Zagrean Ana-Maria
Published: December 2020

Capsaicin is a widespread spice known for its analgesic qualities. Although a comprehensive body of evidence suggests pleiotropic benefits of capsaicin, including anti-inflammatory, antioxidant, anti-proliferative, metabolic, or cardioprotective effects, it is frequently avoided due to reported digestive side-effects. As the gut bacterial profile is strongly linked to diet and capsaicin displays modulatory effects on gut microbiota, a new hypothesis has recently emerged about its possible applicability against widespread pathologies, such as metabolic and inflammatory diseases. The present review explores the capsaicin–microbiota crosstalk and capsaicin effect on dysbiosis, and illustrates the intimate mechanisms that underlie its action in preventing the onset or development of pathologies like obesity, diabetes, or inflammatory bowel diseases. A possible antimicrobial property of capsaicin, mediated by the beneficial alteration of microbiota, is also discussed. However, as data are coming mostly from experimental models, caution is needed in translating these findings to humans.
Probing Substrate/Catalyst Effects Using QSPR Analysis on Friedel-Crafts Acylation Reactions over Hierarchical BEA Zeolites
Authors: Elvas-Leitão Ruben , Martins Filomena , Borbinha Leonor , Marranita Catarina , Martins Angela , Nunes Nelson
Published: December 2020

Attempts to optimize heterogeneous catalysis often lack quantitative comparative analysis. The use of kinetic modelling leads to rate (k) and relative sorption equilibrium constants (K), which can be further rationalized using Quantitative Structure-Property Relationships (QSPR) based on Multiple Linear Regressions (MLR). Friedel-Crafts acylation using commercial and hierarchical BEA zeolites as heterogeneous catalysts, acetic anhydride as the acylating agent, and a set of seven substrates with different sizes and chemical functionalities were herein studied. Catalytic results were correlated with the physicochemical properties of substrates and catalysts. From this analysis, a robust set of equations was obtained allowing inferences about the dominant factors governing the processes. Not entirely surprising, the rate and sorption equilibrium constants were found to be explained in part by common factors but of opposite signs: higher and stronger adsorption forces increase reaction rates, but they also make the zeolite active sites less accessible to new reactant molecules. The most relevant parameters are related to the substrates’ molecular size, which can be associated with different reaction steps, namely accessibility to micropores, diffusion capacity, and polarizability of molecules. The relatively large set of substrates used here reinforces previous findings and brings further insights into the factors that hamper/speed up Friedel-Crafts reactions in heterogeneous media.
Synthetic Peptide ΔM4-Induced Cell Death Associated with Cytoplasmic Membrane Disruption, Mitochondrial Dysfunction and Cell Cycle Arrest in Human Melanoma Cells
Authors: Santa-González Gloria A. , Patiño-González Edwin , Manrique-Moreno Marcela
Published: December 2020

Melanoma is the most dangerous and lethal form of skin cancer, due to its ability to spread to different organs if it is not treated at an early stage. Conventional chemotherapeutics are failing as a result of drug resistance and weak tumor selectivity. Therefore, efforts to evaluate novel molecules for the treatment of skin cancer are necessary. Antimicrobial peptides have become attractive anticancer agents because they execute their biological activity with features such as a high potency of action, a wide range of targets, and high target specificity and selectivity. In the present study, the antiproliferative activity of the synthetic peptide ΔM4 on A375 human melanoma cells and spontaneously immortalized HaCaT human keratinocytes was investigated. The cytotoxic effect of ΔM4 treatment was evaluated through propidium iodide uptake by flow cytometry. The results indicated selective toxicity in A375 cells and, in order to further investigate the mode of action, assays were carried out to evaluate morphological changes, mitochondrial function, and cell cycle progression. The findings indicated that ΔM4 exerts its antitumoral effects by multitarget action, causing cell membrane disruption, a change in the mitochondrial transmembrane potential, an increase of reactive oxygen species, and cell cycle accumulation in S-phase. Further exploration of the peptide may be helpful in the design of novel anticancer peptides.