bluuebunny/crossref_metadata_2025 huggingface dataset:
The ΦPA3 Phage Nucleus is Enclosed by a Self-Assembling, 2D Crystalline Lattice
Authors: Nieweglowska Eliza , Brilot Axel , Méndez-Moran Melissa , Baek Minkyung , Li Junrui , Kokontis Claire , Cheng Yifan , Baker David , Bondy-Denomy Joseph , Agard David
Published: April 2022

A growing number of jumbo bacteriophages, with genomes exceeding 200 kb, have been found to establish a Phage Nucleus—a micron-scale, proteinaceous structure encompassing the replicating phage DNA. Bacteriophage and host proteins associated with replication and transcription are concentrated inside the Phage Nucleus while nucleotide synthesis, translation, and numerous other host and exogenous proteins are effectively excluded, including CRISPR-Cas and restriction endonuclease host defense systems. Here, we show that fragments of the Phage Nucleus isolated from ΦPA3 infected Pseudomonas aeruginosa cells form a square lattice and demonstrate that the recombinantly purified primary Phage Nuclear Enclosure (PhuN) protein spontaneously assembles into sheets also constructed from a square lattice which we resolve to 3.8 Å by cryo-EM. Our structure reveals that the flexible termini and large loops mediate adaptable inter-tetramer contacts that drive shell assembly into a C2-symmetric lattice. While the interfaces between subunits are mostly well packed, two of the interfaces are open, forming clear channels that likely have important functional implications for the transport of proteins, mRNA and small molecules.
Structural evolution is the key to paternal identification in salt-resistant soybean breeding
Authors: lai yongcai , lu jingmei , Yu Haifeng , Yang Guang , Cao Ning , Ma Ying , Bi Ying-Dong , Tao Jing , Gao Wei , Niu Lu , Li Xia , Chen Zi , Wang Ying , Li Yan , Sun Changbin , Li Gang , Wu Dongmei , Liu Cuijing , Zhang Wei , Zhang Ying , Sun Mingchun , Chu Jinmeng , Xia .Fucai , Qi Weichen , Wan Shuyan , M Hassan , Ali Mohammed , Du Xinglin , You Jihong
Published: April 2022

Soybean breeding shows that soybean resources are increasingly narrow due to the depletion of ancestral varieties. We collected salt-tolerant wild soybean samples and seeds from 23 areas affected by heavy salt stress. SEM was used for structural evolution, Plant Print identification, salt and alkali resistance physiology, salt resistance gene and tissue culture experiments. We report here the discovery of Chinese wild soybean salt gland is first reported in the world. The salt tolerance of new soybean varieties is greatly improved by breeding wild soybean with salt gland as the male parent. A batch of new soybean varieties resistant to salt were obtained. The experiment revealed that the diversity of salt tolerance function of wild soybean was closely related to stress tolerance physiology, stress tolerance gene and phylogenetic structure evolution. Our results encourage the use of salt-resistant wild soybeans as paternal breeding to avoid undesirable breeding cycles at the expense of soybean ancestral varieties.
Evaluating ENSO Spatiotemporal Complexity in Climate Model Hindcasts
Authors: Kim Ji-Won , Chang Ting-Huai , Lee Ching-Teng , Yu Jin-Yi
Published: April 2022

Using hindcasts produced by a coupled climate model, this study evaluates whether the model can simulate the observed spatiotemporal complexity in El Niño − Southern Oscillation (ENSO) during 1982 − 2011: the eastern Pacific (EP), central Pacific-I (CP-I) and -II (CP-II) types of El Niño, and the atypical multi-year evolution events of El Niño occurred in 1986‒1988 (i.e., 1986/87/88 El Niño) and La Niña occurred in 1998‒2000 (i.e., 1998/99/00 La Niña). In regards to spatial complexity, it is uncovered that the CP-I type of El Niño is most easily to be hindcasted, CP-II is second, and the EP El Niño type is most difficult to be hindcasted as its amplitude is significantly underestimated. The model deficiency in hindcasting the EP El Niño is related to a warm bias of climatological sea surface temperatures (SSTs) in the tropical eastern Pacific, which is mainly caused by the strengths of the Pacific Walker circulation and South Pacific high that are notably weakened in the model simulation. As for the temporal complexity, the model successfully hindcasts the multi-year evolution of the 1998/99/00 La Niña but fails to hindcast that of the 1986/87/88 El Niño. This contrasting model performance between the ENSO’s multi-year evolution events is related to a cold bias in the model simulation of tropical central Pacific climatological SSTs, which makes La Niña event more easily activate the Pacific basinwide interactions than El Niño event and result in a multi-year evolution pattern.
LncRNA-miRNA crosstalk in HCC cases on top of HCV infection
Authors: El-Araby Rady , Elmorsy Gamal , Saad Ahmed , Elamrosy Hisham , Adel Rana , Elshafie Sara , Helal Hamed , Adel Mohammed , Roshdy Fawzy
Published: April 2022

Hepatocellular carcinoma (HCC) continues to be a serious issue because of its high morbidity and mortality in the absence of early identification and proper treatment. Increasing evidence reveals that long non-coding RNAs (lncRNAs) and micro RNAS (miRNAs) interact to form a gene regulatory network. Their interactions lead to a variety of complex diseases, such as HCC. So, the current study aims to assess whether the interaction between "HOTAIR, HOTTIP, and H19 as lncRNAs and miRNA-152 as a miRNA" has a significant role in the progression of HCV-genotype (4) patients to hepatocellular carcinoma, in order to employ them as noninvasive prognostic and diagnostic epigenetic biomarkers. By using the online computational tools, we predict the group of miRNAs that may interact with the group of lncRNAs under this investigation. 133 subjects were included in this study. A total of 103 chronic hepatitis C patients were divided into two groups: Group I (chronic liver disease “CLD” without HCC, n = 65) was classified into two subgroups: non-cirrhotic (30) and cirrhotic (35); Group II (CLD with HCC, n = 38). A control (healthy volunteer, n = 30). The expressions of the studied genes were analysed by real-time PCR. The study of lncRNAs has shown a consistent reverse correlation with miRNA-152 in line with the progression of the disease, which leads us to suggest that they should be used as noninvasive prognostic biomarkers for HCV-induced liver cirrhosis and HCC in HCV Genotype 4 patients. MiRNA-152 is not the only one that can interact with the lncRNAs that have been investigated, but there are others, such as miRNA-19a and miRNA-106a, that should be considered.
A computational analysis of E2A gene in B & T-Cells Development
Authors: Choudhury Shouhartha
Published: April 2022

The E2A (TCF3) gene reveals a dominant role during lymphocyte and CNS growth. E2A is an object of the E proteins family of TFs. E proteins encoded by bHLH TFs are a key moderator of B & T cells development. Precisely, sequencing of E proteins and antagonists reveals lymphoid development. The B & T cells lineage commitment suggested E2A, HEB, E2-2, ID2/ID3, and other bHLH TFs are necessary at a proximate phase of cellular maturation. E protein controls the responsibility of various factors and antigen receptor-associated genes that promote Ig and TCR rearrangement coordinate cellular growth and survival via TCR signalling. In this research, I applied a computational technique for the genome-wide examination of bHLH TFs in two different organisms. This application can adapt purpose to gain current knowledge of particular TFs in the genome. My observation suggested E proteins, tissue-specific bHLH domain, and antagonists in two organisms. In light of E2A and other components elicit classical molecular mechanisms that reckon B & T- cells development. Therefore, I documented the results of E2A also illustrated the functional mechanism involved in E protein, ID2/ID3, and tissue-specific bHLH TFs in the mammal. In some conditions, the combined functions of E2A, E2-2, HEB, ID1-ID3, and other molecular interactions lead to tumour suppressor activity in tumour biology.
Association between employment status and suicidal ideation among Korean employees
Authors: Kim Sun Mi , Oh Jae Won , Son Nak-Hoon , Lee San
Published: April 2022

Employment status is a key indicator of socioeconomic status. However, research in Asian cultures for the association between employment status and mental health have been limited. The current study investigated the association between employment status and suicidal ideation. Using data from the 2015, 2017, and 2019 Korea National Health and Nutrition Examination Survey, 6,509 participants aged ≥ 20 years were analyzed. Multivariable logistic regression and subgroup analysis were performed. Unemployed status demonstrated 1.85 times more suicidal ideation than employed (adjusted Odd Ratio (aOR) 1.85, 95% confidence interval (CI) 1.41–2.44, p < .001). Low educational attainment (aOR 2.12, 95% CI 1.51–2.98, p < .001), low income (aOR 1.61, CI 1.22–2.14, p < .001), presence of stress recognition (aOR 3.06, 95% CI 2.33–4.02, p < .001), and depression (aOR 13.0, 95% CI 10.0-16.9, p < .001) were also associated with suicidal ideation. In subgroup analysis, all covariates, except women and low BMI, have combined effects with employment status on suicidal ideation. This study showed the association between employment status and suicidal ideation. Suicidal ideation occurs in a complex manner due to various factors, it is important to provide support based on a comprehensive understanding of suicidal ideation related to employment status.
Anticancer studies of Imine analogues
Authors: Naz Asia , Qazi Syeda Uroos , Javed Aneela
Published: April 2022

A series of imine derivatives (3a-m) including thio-semicarbazone, semicarbazone, thiazole and oxazole functional moieties were examined for anti-cancer activity in-vitro by MTT assay using glioblastoma cell line (U87). Among all compound 3m was most potent compound with IC50 value of 8.86 ± 0.15 µM. Cytotoxicity of compounds were evaluated using normal human embryonic kidney cell line i.e HEK-293. Moreover, antibacterial activity of synthesized derivatives was also evaluated by disc diffusion method.
Morphological characterization and selection of maize genotypes for the semiarid region
Authors: Silveira Eduarda Santos , Lima Beatriz Barreto , Santos Alisson Menezes , Silva Alex Florentino , Feitosa Darliton Alex Silva , Santos Barbara Nascimento , Oliveira Tâmara Rebecca Albuquerque , Oliveira Gustavo Hugo Ferreira
Published: April 2022

Maize has great importance in the semi-arid region of Sergipe. The zoning of the culture in the region is due to the studies directed to the selection and adaptability of genotypes to adverse conditions. In view of this, the objective was to characterize and select corn genotypes for grain production in the semi-arid region of Sergipe. For this, 78 corn genotypes were evaluated in Nossa Senhora da Glória, Sergipe, Brazil. Using the BLUE's estimates for grain yield, 43 genotypes were selected. It was observed that the earliest genotypes corresponded to the highest average in grain yield, therefore, the characteristics related to flowering can be used in the indirect selection of genotypes. The experimental XB7530, DGX20 S03, DGX20 S02, DGX20 S01, LG 6036 PRO3 and EX3561L VIP3 were selected, and these provided 551.15 kg ha-1 of genetic gain in the experimental population. Furthermore, these are indicated for the formation of dialels in a breeding program in the semiarid region of Sergipe.
Extensive Myocardial Infarction Complicated with Stroke as the First Presentation of HIV in A Young Sudanese Male: A Case Report
Authors: Eljack Moh. Mah.Fadelallah , ali Najla Fouad Nassir Mohammed , Ahmed Khabab Abbasher Hussien Mohamed , Ahmed Omer Idris , Nour Alshareef B. , Haroun Mazin S. , Abdallah Abdallah M. , Ali Mustafa Mohamed Ibrahim
Published: April 2022

Introduction: As it is a disseminated disease, HIV infection can be associated with significant cardiovascular and neurological complications; however, this commonly occurs late. Here, we highlight the unusual initial presentation of HIV infection, which is myocardial infarction complicated by stroke.Case Presentation: A 30 years old male with a clear medical background presented with severe chest pain with evidence of ischemia on ECG and positive serum troponin. he received anti-ischemic drugs, and was prepared for coronary angiography with routine investigations tested positive for HIV; however, his condition was later complicated by stroke. Conclusion: The presentation of acute coronary syndrome in a young patient should raise suspicion of uncommon causes and needs prompt evaluation from digging up in history, detailed examination and investigations with close follow-up to prevent the complications that may occur. on the other hands known HIV Patients should be screened periodically with electrocardiogram
Spatial-Spectral Hyperspectral Images Classification Based on Krill Herd Band Selection and Edge-Preserving Transform Domain Recursive Filter (KHBS-ETDRF)
Authors: Moharram Mohammed Abdulmajeed , Sundaram Divya Meena
Published: April 2022

Hyperspectral images (HSI) have recently been exploited in several aspects as they contain many contiguous narrow spectral informative-rich bands. The curse of dimensionality in hyperspectral images is an essential challenge as it possesses plenty of redundant bands that lead to the Hughes phenomenon. However, many feature selection or band selection techniques have been performed for dimensionality reduction of HSI. In this manuscript, firstly, a novel approach for spectral bands selection process is presented for hyperspectral images dimensionality reduction using Krill Herd (KH) Algorithm. However, KH is a heuristic search method that seeks to reach the optimum global solution within the search space and evade falling into the local optima. KH relies on simulating the herding behavior of krill in the sea in order to determine the most informative and relevant bands. Secondly, an Edge-preserving filter (EPF) was utilized to extract the spatial characteristics while reducing noise and obtaining a suitable smoothing that improves the performance of the classification process. Finally, the support vector machine (SVM) classifier at pixel level was performed for the classification of HSI. Moreover, the proposed work was compared to the Harmony Search (HS), Genetic Algorithm (GA), Bat Algorithm (BA), Particle Swarm Optimization (PSO), and Firefly Algorithm (FA). In addition, the classification results for overall accuracy (OA) on four popular publicly datasets were 96.54%, 98.93%, 99.78%, and 98.66% for the Indian Pines scene, the Pavia University scene, the Salinas scene, and the Botswana scene, respectively.
Systemic Immune-Inflammation Index and serum albumin predict prognosis in rectal cancer patients undergoing curative resection
Authors: Qiao Yating , Zhang Aimin , Zhang Tao , Bai Tianliang , Peng Xinyu , Lin Hengxue
Published: April 2022

Background: Systemic nutrition and inflammation have been reported to be associated with the prognosis of various cancers. The aim of this study is to explore the predictive value of systemic immune-inflammation index (SII) and serum albumin in postoperative prognosis for patients with rectal cancer(RC) who received curative resection. Methods: A total of 184 eligible RC patients were included in this retrospective study. X-tile software was used to determine the optimal cut-off values for SII and serum albumin. The relationship between serum albumin/SII and clinicopathological parameters was analyzed. The effects of serum albumin and SII on overall survival (OS) were assessed by univariate and multivariate Cox proportional hazards model analysis and Kaplan-Meier curves.Results: The ideal preoperative cut-off points of NLR, PLR, and OPNI were 2.5, 133.3, and 39.5, respectively. Multivariate Cox regression analysis identified that the lymphocyte (P =0.011), Serum albumin (P=0.010), SII (P =0.012) and tumor diameter (P=0.032) were significant prognostic markers for OS. The median OS in the Serum albumin-low and Serum albumin-high groups was 22 months and and not observed (P < 0.001), and that in the SII-high and SII-low groups was 15 months and not observed (P < 0.001), respectively.Conclusions: SII and serum albumin could be feasible and promising biomarkers for prognosis in RC patients who received curative resection.
Isolation of a Novel Antimicrobial Polypeptide from Aspergillus Niger Isolate LC3
Authors: ÜSTÜN Ayşe , YAZICI Ayşenur , ÖRTÜCÜ Serkan
Published: April 2022

There is a need to discover new antimicrobial agents due to increasing resistance to antibiotics. Researchers focused on AMPs (antimicrobial polypeptide) for these new agents discovered before antibiotics and did not develop resistance as much as antibiotics. In this study the extracellular proteins from isolate LC3 belonging to Aspergillus were purified for new AMP discovery and then tested for antimicrobial activity against Staphylococcus aureus (ATCC 25923) and Methicillin-resistant Staphylococcus aureus (MRSA). Antimicrobial activity was determined by the trypsin/proteinase K assay, which was polypeptide-based, and it was observed that this protein was a protein of about 11 kDa by gel overlay assay. Then the minimum inhibitory concentration of purified AMP molecule against S. aureus ATCC 25923 and MRSA was 8 µg/ml and 32 µg/ml, respectively and the AMP molecule was confirmed. ITS sequence analysis showed that isolate LC3 was identified as Aspergillus niger, using the Bioedit sequence assembly program, the sequence was deposited with the GenBank database with accession number MK332597. These results indicate that the purified AMP molecule has the potential to be used in infections caused by S. aureus.
Socioeconomic drivers of healthcare utilization among the elderly with reference to working and non-working population: Insights from LASI
Authors: Nath Nayan Jyoti , Chaudhary Aditi , Kumar Shubham
Published: April 2022

Background: The elderly population of India has been escalating exponentially over the past few decades, caused by a decline in fertility and an increase in life expectancy. The increase eventually transcended the disease burden on the public healthcare system. Therefore, it becomes crucial to evaluate the healthcare utilisation pattern of the elderly based on their socioeconomic and working condition.Methods: To measure healthcare utilisation, we have used access to public and private healthcare services. Descriptive analysis and multivariable logistic regression were used to understand utilisation patterns by working status and some selected sociodemographic parameters. All the results were reported at a 95% confidence interval.Results: We have used the data from the first wave of longitudinal ageing study of India (LASI) with a sample of 22,680 older persons 60 years and above. The study identified that 50 per cent of the working elderly access private service; however, 26 per cent access public healthcare services. It was found that working status of the elderly alone did not influence access to healthcare services, but education is also an essential indicator for utilising healthcare services. Further, factors such as gender, marital status, religion, wealth, tobacco usage, self-rated health, ADL and IADL were significant contributors to utilising healthcare services in the elderly.Conclusion: This study suggests that working status and other sociodemographic indicators are associated with the utilisation of healthcare services, highlighting that increasing health needs among the elderly requires strengthening the quality and appropriate public investment in health.
Pan-cancer analysis: Predictive role of TAP1 in cancer prognosis and responses of immunotherapy
Authors: Tu Zewei , Li Kuangxun , Huang Yuyang , Lv Shigang , Li Jingying , Wu Lei , Huang Kai , Zhu Xingen
Published: April 2022

Background: Transporter associated with antigen processing 1 (TAP1) is a transporter that processes and presents the major histocompatibility complex class I (MHC-I) restricted antigens, including tumor-associated antigens. TAP1 is aberrantly expressed in multiple cancer types, and also involves in tumor immunity. Therefore, the predictive role of TAP1 in cancer development and treatment is expected. Methods: Transcriptomic profiles were obtained from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) database. Genetic alteration, protein distribution and interaction information were downloaded from cbioPortal, Human Protein Atlas (HPA) and Compartmentalized Protein-Protein Interaction (ComPPI), respectively. Single-cell analysis was conducted on Tumor Immune Single-cell Hub (TISCH) website. Gene set enrichment analysis (GSEA) was employed to investigate the functioning mechanism of TAP1 by R package “clusterProfiler”. Immune cell infiltration of Pan-cancer was explored by Tumor Immune Estimation Resource (TIMER) 2.0 webtool and visualized by R programming language. Correlation between TAP1 expression and immunotherapy biomarkers was explored using Spearman’s correlation test. Association with immunotherapy responses of TAP1 was investigated using the information of the cancer cohorts with patients received immune checkpoint inhibitors (ICIs). Results: TAP1 expression was elevated in most pan-cancer types and exhibited distinct prognostic value in diverse cancer types. Within tumor tissues, immune cells expressed more TAP1 than malignant cells. TAP1 expression was significantly correlated with immune-related pathways, infiltration of T lymphocytes and immunotherapeutic biomarkers. Cohort validation revealed a significant correlation with immune therapeutic effects and verified the prognostic role of TAP1 in immunotherapy. Western blot assay indicated that TAP1 is upregulated in GBMs compared with adjacent normal brain tissues (NBTs).Conclusion: TAP1 was a robust tumor biomarker, and a novel predictor of clinical prognosis and immunotherapeutic responses in distinct cancer types.
Predicting the risk of acute kidney injury after hematopoietic stem cell transplantation： development of a new predictive nomogram
Authors: Gan Zhaoping , Chen Liyi , Wu Meiqing , Liu Lianjin , Shi Lingling , Li Qiaochuan , Zhang Zhongming , Lai Yongrong
Published: April 2022

Purpose: The purpose was to predict the risk of acute kidney injury (AKI) within 100 days after hematopoietic stem cell transplantation (HSCT) in patients with hematologic disease by using a new predictive nomogram.Methods: Collect clinical data of patients with hematologic disease undergoing HSCT in our hospital from August 2012 to March 2018. Parameters with non-zero coefficients were selected by the Least Absolute Selection Operator (LASSO). Then these parameters were selected to build a new predictive nomogram model. Receiver operating characteristic (ROC) curve, calibration curve, C-index, and decision curve analysis (DCA) were used for the validation of the evaluation model. Finally, the nomogram was further evaluated by internal verification.Result: According to 2012 Kidney Disease Improving Global Guidelines (KDIGO) diagnostic criteria, among 144 patients, the occurrence of AKI within 100 days after HSCT The rate was 29.2% (42/144). The C-index of the nomogram was 0.842. The C-value calculated by the internal verification was 0.809. The AUC was 0.842, and The DCA range of the predicted nomogram was from 0.01 to 0.71.Conclusion: This article established a high-precision nomogram for the first time for predicting the risk of AKI within 100 days after HSCT in patients with hematologic diseases. The nomogram had good clinical validity and reliability. For clinicians, it was very important to prevent AKI after HSCT.
A comparative NMR-based metabolomics study of lung parenchyma of severe COVID‑19 patients
Authors: Hurtado Joaquín I. , López-Radcenco Andrés , García José Luis Izquierdo , Moyna Guillermo , Rodriguez Fernando , Greif Gonzalo , Nin Nicolas
Published: April 2022

The COVID-19 pandemic was the leading cause of mortality due to a single infectious agent in 2020 and 2021. The fatality rate for individuals admitted to the ICU for this condition was over 60%. A metabolomic analysis based on nuclear magnetic resonance was performed on patients who died in the ICU due COVID-19 and other fatal respiratory diseases. Although there is information on metabolic signatures in COVID-19 patients' serum and plasma, little is known about the infection site in the lungs. We found statistically significant differences between metabolites related to energy metabolism and inflammatory processes, revealing a unique metabolic profile.
Time-varying spatial accessibility of primary healthcare services based on temporal variations in demand, supply, and traffic conditions: A case study of Seoul, South Korea
Authors: Kim Kyusik , Kwon Kyusang
Published: April 2022

Background: Although demand, supply, and traffic conditions are interdependent, scholars have considered them separately when measuring the accessibility of healthcare services. Additionally, the temporal variations in these three factors is given relatively less attention in healthcare accessibility research, which mislead the wise policy decisions of healthcare planners. This study aims to examine the spatiotemporal variability of accessibility to primary healthcare services and identify areas with spatial discrepancy between time-varying and static accessibility models in Seoul, South Korea. Methods: Using the generalized two-step floating catchment area method, we measure time-varying spatial accessibility with de facto population from hourly-collected mobile-based data, available healthcare facilities, and actual traffic conditions in Seoul, South Korea. Additionally, the bivariate Local Moran’s I allowed for the identification of the areas with discrepancy between the two accessibility models.Results: The results show that a geographical pattern of time-varying accessibility significantly differs with that of static accessibility. Time-varying accessibility is lower in commercial areas and higher in residential areas, compared with static accessibility, whose accessibility is higher in central Seoul. The result of the bivariate Local Moran’s I analysis highlights that ignoring time variations of the three factors will result in overestimation in commercial areas and underestimation in residential areas. Based on the discrepancy between the two models, we typified overestimated areas and underestimated areas as attention needed and false attention areas, respectively.Conclusion: We suggest areas in which the healthcare policy needs to pay more attention by identifying areas with spatial discrepancies between time-varying accessibility and static accessibility. Considering the time variations will provide a more realistic impression of spatial accessibility to primary healthcare.
Association between arsenic concentration of groundwater and mortality from leukemia and urological cancers in the northwest of Iran
Authors: khamutian samira , Rahmani Alireza , Doosti-Irani Amin , Shokoohizadeh Mohammad J. , Razdari Roya Ahmaddoost , Niksiar Sharareh
Published: April 2022

Arsenic is one of the most important toxic elements in the environment and considered as a challenging threat to human health. The present study aims to determine the relationship between arsenic concentration in groundwater and mortality rates due to urological, and leukemia malignancies in Hamadan, Iran, as a hotspot of arsenic concentration. A total of 370 samples of tap water from urban and rural areas in all 9 counties of the Hamadan province was collected by grab sampling method. IBM SPSS Statistics V22.0 and linear regression model were applied to investigate the relationship between arsenic levels and mortality rates. The inverse distance weighting (IDW) method in ArcGIS 10.8 software was used to show spatial patterns of arsenic concentration and to estimate the unknown points. According to the results, in rural regions of Kaboodarahang, including Qapaqtapeh-ye Kord, Churmaq, Quhurd-e Olya, Qohurd-e Sofla, Jaganlu, the concentration of arsenic in groundwater were obtained 91.73±19.81, 100.45±20.3, 185.4±69.05, 180.5±31.2, 160.75±41.64 ppb, respectively. In some areas of Malayer and Nahavand, the As concentration ranged 1.7 - 10 times higher than standard values. Based on linear regression fitting, the risks of mortality for urological cancer, were 4.25 per 100,000 for men, and 1.28 per 100,000 for women, and regarding leukemia, they were 4.56 and 6.76 per 100,000 for men and women, respectively. In conclusion, this study provides an evidence that an exposure to high levels of arsenic was significantly associated with mortality rate due to leukemia and urological cancer.
The Human Well-being and Environmental Degradation Nexus in Africa
Authors: Aladejare Samson Adeniyi
Published: April 2022

Environmental degradation continues to attract interest from academics, policymakers, and other stakeholders. However, empirical studies have been limited particularly in the choice of human well-being indicators. Therefore, this study extends the literature by broadening the nexus between human well-being and environmental degradation in 29 African countries from 1970 to 2019. Preliminary tests adaptable to effects of cross-sectional dependency and heterogeneity in panel dataset were adopted, alongside the cross-sectional auto-regressive distributed lag model and the Dumitrescu-Hurlin causality approach. Findings from the study showed that the adopted human well-being indicators such as globalisation, life expectancy and human capital development were environmentally enhancing both in the short and long term. In contrast, growth in income was found to be environmentally degrading in the short and long term. At the same time, urbanisation was only environmentally detrimental in the long term with no significant short-term effect. Natural resource rent which served as a control variable was environmentally degrading both in the short and long term. Also, a bidirectional association between human well-being and environmental degradation was confirmed. Consequently, this study implies a win-win symbiotic nexus between the environment and human well-being in African countries.
Combined Influence of Rainfall and Groundwater on the Stability of an Inner Dump Slope
Authors: Wang Zhiliu , Liu Bo , Han Yanhui
Published: April 2022

Landslides are a commonly encountered natural disaster throughout the worldwide. Among the various contributing factors, water is one of the major factors to induce slope instability. This work investigates the landslide problem induced by the combined action of rainfall infiltration and groundwater. To explore the correlation characteristics between the stress and stability of the dump slope under the coupling action of groundwater and rainfall, a mechanical model of the dump slope under the coupling action of groundwater and rainfall was established and a theoretical solution of FoS was developed to accommodate the effects of the seepage action of water and the strength reduction of soil in the process of water migration. It was determined that the primary factor inducing slope instability can change with groundwater and rainfall conditions. There exists a critical wetting front and critical groundwater depth where the dominant factor affecting slope safety changes, and a method for calculating the critical depth for slope instability is proposed. As groundwater depth increases, the critical wetting front depth increases; correspondingly, the critical FoS decreases. As the depth of the wetting front extends, the critical groundwater depth rises and FoS decreases. Meanwhile, the theoretical solutions are validated in a case study for the Shengli #1 open-pit mine. The results of the study may provide directional guidance for the stability analysis of similar slopes.
Diabetes treatment cost analysis in Jilin Province in 2016- 2019 using the structural change method
Authors: Zhou Zheng , Yu Jianxing , Jia Huanhuan , Feng Tianyu , Yu Xihe
Published: April 2022

Aim: To analyse the development trend of diabetes treatment costs in Jilin Province and its related factors from 2016-2019 and to provide a theoretical basis for the reform of the health care system in Jilin Province, the reduction of residents' disease burden and the formulation of relevant policies.Method: Based on the SHA2011 method of health cost accounting, the data on diabetes treatment expenses in Jilin Province were collated. The change trend of diabetes treatment cost and project constitution in Jilin Province was analysed by structural analysis.Results: The total cost of diabetes treatment increased from 2 billion 348 million yuan in 2016 to 2 billion 833 million yuan in 2019, with an average annual growth rate of 6.46%. The average outpatient expenses for diabetes in Jilin increased from 240.53 yuan to 304.61 yuan, corresponding to an average annual increase of 8.19%. The average hospitalization expenses related to diabetes in Jilin Province decreased from 7280.63 yuan to 6707.33 yuan, a decrease of 2.70%.Conclusion: The cost of diabetes treatment in Jilin Province showed a rapid growth trend. The increase in hospitalization expenses was mainly due to the increase in the number of outpatients. The increase in outpatient expenses was mainly due to the increase in average outpatient expenses.
A pattern of Covid morbidity expression in the industrial backdrop of Paschim Burdwan
Authors: Chatterjee Rishika , Mukherjee Rishav , Mitra Arup kumar , Das Satadal
Published: April 2022

Objectives: The study was conducted to know how Covid-19 and TB affected the people of Paschim Burdwan, India for 12 months period (from August 2020 to July 2021).Materials and Methods: Covid-19 cases were studied in terms of age groups (viz.≤19,≥20 to≤45,≥46 to ≤60 years and >60 years)and genders forfirst and second waves of Covid -19 in the mentioned part of our country.Results and Conclusions: It was found that most of the peopleof ≥20 to≤45 years of age were affected more compared with other groups. In the 0-19 age group, females were more affected (7.44%) than males (4.74%)and few of them were statistically evaluated.Pollution parameters viz. Nitrogen oxides(NOx), Carbon oxides(COx), Sulphur oxides(SO2), particulate matters ( PM2.5, and PM10) in the Asansol area of Paschim Burdwan were studied for the month of July 2019,2020 & 2021but there was no significant change and they are not linked to increased Covid-19 cases.
Mental health and associated factors for Vietnamese migrants in Japan during the COVID-19 pandemic: A comparative analysis on resident status
Authors: Thi Hue Tran , Kitajima Tsutomu , Takeshi Sawada , Hiroko Miyakubi
Published: April 2022

Background
The ongoing Coronavirus disease 2019 (COVID-19) pandemic has had wide-ranging health and socio-economic effects on the global population. This impact, however, is not uniform across all sections of the population. It has been observed that migrants to other countries, who relocate from their home countries for better living conditions, are more vulnerable to such disruptions than the general population. This study attempts to assess the health and economic challenges faced by Vietnamese migrants living in Japan.
Methods
We conducted a cross-sectional study of 589 Vietnamese residents in Japan using a self-administered questionnaire that included a 20-item tool from the Center for Epidemiologic Studies – Depression Scale (CES-D) as well as questions related to the pandemic and socio-demographic information. We examined to what extent and how, (1) pandemic-related risk factors such as COVID-19 infection, access to health care, job and food insecurity; (2) socio-demographic factors such as age, gender, length of stay, language proficiency; and (3) protective factors such as perceived social support, were associated with mental health outcomes. We also investigated who were more vulnerable among this group of migrants.
Results
The results showed that nearly half the participants had depressive symptoms higher than the general population in Japan. Students reported a higher prevalence of depressive symptoms (47.6%, 16.9 ± 9.0) than those with other resident statuses. Multivariable logistic regression analysis revealed that more severe depressive symptoms were associated with self-perceived poor health conditions, and difficulties in accessing health facilities. Perceived social support, however, was observed to be a protective factor against depression.
Conclusions
Although measures are taken to protect people from COVID-19, it has created depression and uncertainty among the Vietnamese migrants, which needs to be addressed immediately. Findings from this study can guide efforts to build more effective public health approaches to reduce the burden of mental health among vulnerable populations within Japan and globally.
Bioinformatic Characterization and Phylogenetic Analysis of Cold-Regulated Genes Across the Genus Eucalyptus
Authors: Malakar Ayushman , Barthwal Santan , Chandra Girish
Published: April 2022

Cold or frost stress is one of the severest abiotic stresses which hinders the distribution, productivity and yield of Eucalyptus worldwide. Almost all aspects of cellular functions are affected under the exposure of cold stress. Being an economically important species, development of cold tolerance in Eucalyptus is very important. Different signalling cascades are known to be activated under cold stress. ICE1-CBF pathway is found to play master regulatory role in cold stress sensing pathways in majority of woody forest plants. In this study, across the genus Eucalyptus, 24 cold-regulated genes (CORs) are identified, divided in 3 gene families namely ICE, CBF and DHN, characterized by the presence of signature motifs and conserved domains in the sequences. Exhaustive location on chromosomes and sequences for these genes are acquired from several databases. These sequences are further analysed with several bioinformatic tools to establish evolutionary relationships among them. Predicted protein sequences from BLASTX are subjected to multiple sequence analysis and percentage similarity matrices are constructed with BLOSUM62. Phylogenetic trees for every gene family are developed using MEGA X using the Maximum Likelihood (ML) method and statistically validated through bootstrapping method. The analysis of these ICE, CBF and DHN genes directed towards cross-talk of different stress response pathways. Cluster of CBF genes are found in Eucalyptus resembling high similarity suggesting a major duplication event during the evolutionary track of this genus. The results of this study will prove to be beneficial in understanding the cold acclimation process and developing genetically improved cold tolerant Eucalyptus.
A Novel Technique for Monitoring Infant Feelings Using IoT
Authors: prasad saurabh , Prasad Ramjee
Published: April 2022

Human bond communication( HBC ) is a concept where we try to communicate our feelings observed by the five sensory organs namely eye, ear, nose, tongue, skin. This concept is in initial stage and till date we are able to transfer only those data which is observed by the eye and ear using modern communication technology. To communicate data we generally use human understandable communication language and advance technology. Main problem arises when we try to get information from an infant. Infant does not know any type of human understandable communication language or technology. To know infant feelings observed by the sensory organs is a challenging task. The objective of research is to protect infant by knowing what they are feeling and to develop, manufacture cost effective, efficient with highest level of efficiency to aggregate or segregate data point based on local, domestic, regional and global level .Our proposed paper, a prototype system which is capable enough to know and transfer infant’s feelings. Here we have used Internet of Things ( IoT ) technology to know feelings of an infant and protecting them from Sudden Infant Death Syndrome ( SIDS ).
GEOLOGICAL AND ECONOMIC ASSESSMENT OF ORE URANIUM DEPOSITS IN A MARKET ECONOMY
Authors:   Transbaikal State University, Chita, Ovseychuk V.
Published: April 2022

PJSC "Priargunskoye Production Mining and Chemical Association" (PJSC PPGHO) has been mining rock uranium ores since 1968. The overwhelming volume of ore is extracted by the "horizontal layers with a hardening bookmark" system. The cost of the extracted ore is very high. Over a fairly long period of field operation, the raw material base has been largely depleted. The applied mining technology does not provide a cost-effective production of finished products of the enterprise "nitrous oxide-uranium oxides". A massive transition to physical and chemical technologies for the extraction and processing of uranium ores could ensure profitable production, but this requires a geological and economic reassessment of the remaining reserves of uranium ores. The object of the research is uranium mines. The subject is presented by the geological and economic assessment of ore uranium deposits. The purpose of the study is to adapt the methodology of geological and economic assessment of deposits to the conditions of mining uranium deposits. The objective of the study is to establish the dependences of the economic indicators of the development of uranium deposits on the mining and geological characteristics of these deposits. The research methodology is the collection of initial information, its mathematical and statistical processing, and establishment of relationships between indicators, the formulation of methods of geological and economic assessment of uranium deposits. The research methods are presented by mathematical statistics. The article proposes a method for automated recalculation of uranium ore deposits according to changing operational conditions. The methodology is based on the following conditions: close dependence of changes in the reserves of uranium ores in the subsurface on the onboard content of uranium and the power of rock inclusion in the contour of the ore body; identity of the linear reserves of uranium ores with the volume indicators of the reserves of these ores. The calculations, performed according to this method on the basis of the reserves of the conditional operational block, mineralization parameters which correspond to the average ore indicators of the Streltsovsky ore field deposits, have allowed to generally assess the remaining reserves and recommend this method for use on an industrial scale. The results of calculations show that the remaining reserves can provide a cost-effective production of uranium nitrous oxide at a price of $ 60 per kg, while the profitability of production will be 19 %
SIMULATION OF HIGHER EDUCATION (UNIVERSITIES) SYSTEM PERFORMANCE IN THE VOLGA FEDERAL DISTRICT
Authors:   Mari State University, Yoshkar-Ola, Bakumenko L.
Published: April 2022

The article is devoted to the multidimensional classification method application - a generalized discriminant analysis for the classification of universities in the Volga Federal District by the level of efficiency. The subject of the research is the possibility of classifying universities according to the effectiveness and results of their activities. The purpose of the work is to determine the real situation and positions of 90 universities in the Volga Federal District according to three levels of efficiency: high，medium，low. Discriminant analysis was used as a research method. With the help of discriminant analysis，a predictive model is created (the formation of classification functions)，which makes it possible to classify other universities according to the selected system of indicators to check the possible assignment of them to one of the groups according to the level of their effectiveness. To carry out the classification，the variable “Expert assessment”，categorical predictors have been determined as a dependent variable: “Type of university”，“Accreditation”，“Dormitory”，continuous predictors (these are the numerical variables “Number of students”，“Average score of the Exam”，“Number of training areas” and “Number of publications of the RSCI”). Thus, according to the results of the analysis, an automatic classification has been created, which allows it to be used in the future to more accurately determining of a particular university class without contacting with experts. To improve the accuracy of the classification, it has been determined which of the observations are classified incorrectly and the relevant expert assessments have been corrected. To do this, the values of the squares of mahalanobis distances and a posteriori probabilities have been analyzed. Thus, using classification methods with training, it is possible to build models that can be used for the purposes of preliminary analysis and forecasting of the activities of both higher education institutions based on the results of their activities, and other enterprises and firms
POVERTY IN PANDEMIC COVID-19: SOCIAL AND POLITICAL ANALYSIS (PART 2. POLITICAL CAUSES OF POVERTY IN MODERN SOCIETY)
Authors:   Transbaikal State University, Chita, Ivanova M.
Published: April 2022

The article dea丨s with the problem of pandemic poverty in the context of public po丨icy and internationa丨 relations. The re丨evance of the topic is due to the growing number of needy popu丨ation on the p丨anet in conditions of COVID-19 and the need for policy measures to reduce it. The object of the study: the phenomenon of poverty in the context of the pandemic. The subject of the research: the main political factors influencing the dynamics of poverty in the context of the pandemic. The aim of the study is to identify the potential of public policy and internationa丨 relations in the fight against poverty in the context of the pandemic. The research objectives are the following: 1) to clarify the categorical apparatus of poverty research, 2) to give a system characteristic of the features of the world community in the XX-XXI centuries, which changed the phenomenon of consumption,3) to analyze the influence of international relations on the dynamics of poverty during the pandemic, 4) to determine the difficulties and opportunities of Russian state policy aimed at overcoming poverty in the conditions of the pandemic■丨n the study a systemic approach, formational, stadia丨-civilizational, anthropological and logical methods have been used. As a result of the poverty study and the current political situation in the world, scientists defined the concept of poverty, its criteria, presented a classification of its types and causes, as well as ways to combat it. The impact of the pandemic on the growth of poverty has been analyzed, the main contradictions in modern international relations were identified. The author's scientific contribution consists in the analysis of the main political factors of influence on the dynamics of poverty in the pandemic. The author's contribution is represented by the following results. If before the middle of the XX century the technical and technological causes of poverty were the determining ones, in the modern society the political causes of poverty dominate. In the conditions of the pandemic, such traditional political factors of negative impact on the dynamics of poverty, as a high level of corruption in the field of management and instability in international relations, distracting a huge part of the budget to the sphere of defense are intensified. This article is divided into two parts. The first part deals with the social analysis of poverty and its causes in the XX-XXI centuries. The second part presents an analysis of the political factors influencing the dynamics of poverty in the pandemic