bluuebunny/crossref_metadata_2025 huggingface dataset:
Improving Environmental and Energy Efficiency in Wood Transportation for a Carbon-Neutral Forest Industry
Authors: Palander Teijo , Haavikko Hanna , Kortelainen Emma , Kärhä Kalle , Borz Stelian Alexandru
Published: November 2020

Wood transportation is an important source of greenhouse gas emissions, which should be considered when the carbon neutrality of the forest industry is of concern. The EU is dedicated to improving technology for a carbon-neutral development. This study investigates carbon neutrality by improving road freight transportation fleets consisting of various vehicle size combinations. The environmental emission and energy efficiency of a transportation fleet were analyzed in selected wood procurement regions of Stora Enso corporation (Finland). Based on the enterprise resource planning (ERP) data (2018–2020), the environmental emission efficiency increased by 11% via 76 t-vehicles compared 64 t vehicles. The maximum reduction in fuel consumption was 26% for 92 t vehicles, though this was achieved when operations were fully adjusted to the maximum weight limit. The wood-based energy efficiency measure (wood energy/transport energy) was a useful development indicator. It showed that the adapted fleets of transportation companies support a positive development for a carbon-neutral forestry. In respect to the current legal fleet (64, 68 and 76 t), the use of 76 t vehicles increased energy efficiency most effectively, by 50%, compared to 64 t vehicles in the best region. Currently, transportation service providers and their clients are using ERP information to tailor their energy efficiency metric and to implement them locally in the transportation monitoring systems. A three-year sensitivity analysis demonstrates that the technological development of management tools to improve transportation efficiency is essential for larger and heavier vehicle utilization. In the future, the whole wood supply chain from forest to factory will also be optimized with respect to energy efficiency criterion to ensure a low-carbon forest industry.
Whole Exome Sequence Analysis Provides Novel Insights into the Genetic Framework of Childhood-Onset Pulmonary Arterial Hypertension
Authors: Gelinas Simone M. , Benson Clare E. , Khan Mohammed A. , Berger Rolf M. F. , Trembath Richard C. , Machado Rajiv D. , Southgate Laura
Published: November 2020

Pulmonary arterial hypertension (PAH) describes a rare, progressive vascular disease caused by the obstruction of pulmonary arterioles, typically resulting in right heart failure. Whilst PAH most often manifests in adulthood, paediatric disease is considered to be a distinct entity with increased morbidity and often an unexplained resistance to current therapies. Recent genetic studies have substantially increased our understanding of PAH pathogenesis, providing opportunities for molecular diagnosis and presymptomatic genetic testing in families. However, the genetic architecture of childhood-onset PAH remains relatively poorly characterised. We sought to investigate a previously unsolved paediatric cohort (n = 18) using whole exome sequencing to improve the molecular diagnosis of childhood-onset PAH. Through a targeted investigation of 26 candidate genes, we applied a rigorous variant filtering methodology to enrich for rare, likely pathogenic variants. This analysis led to the detection of novel PAH risk alleles in five genes, including the first identification of a heterozygous ATP13A3 mutation in childhood-onset disease. In addition, we provide the first independent validation of BMP10 and PDGFD as genetic risk factors for PAH. These data provide a molecular diagnosis in 28% of paediatric cases, reflecting the increased genetic burden in childhood-onset disease and highlighting the importance of next-generation sequencing approaches to diagnostic surveillance.
Design, Operation and Optimization of Constructed Wetland for Removal of Pollutant
Authors: Rahman Md Ekhlasur , Bin Halmi Mohd Izuan Effendi , Bin Abd Samad Mohd Yusoff , Uddin Md Kamal , Mahmud Khairil , Abd Shukor Mohd Yunus , Sheikh Abdullah Siti Rozaimah , Shamsuzzaman S M
Published: November 2020

Constructed wetlands (CWs) are affordable and reliable green technologies for the treatment of various types of wastewater. Compared to conventional treatment systems, CWs offer an environmentally friendly approach, are low cost, have fewer operational and maintenance requirements, and have a high potential for being applied in developing countries, particularly in small rural communities. However, the sustainable management and successful application of these systems remain a challenge. Therefore, after briefly providing basic information on wetlands and summarizing the classification and use of current CWs, this study aims to provide and inspire sustainable solutions for the performance and application of CWs by giving a comprehensive review of CWs’ application and the recent development of their sustainable design, operation, and optimization for wastewater treatment. To accomplish this objective, thee design and management parameters of CWs, including macrophyte species, media types, water level, hydraulic retention time (HRT), and hydraulic loading rate (HLR), are discussed. Besides these, future research on improving the stability and sustainability of CWs are highlighted. This article provides a tool for researchers and decision-makers for using CWs to treat wastewater in a particular area. This paper presents an aid for informed analysis, decision-making, and communication. The review indicates that major advances in the design, operation, and optimization of CWs have greatly increased contaminant removal efficiencies, and the sustainable application of this treatment system has also been improved.
Occupants’ Health and Their Living Conditions of Remote Indigenous Communities in New Zealand
Authors: Su Bin , Wu Lian
Published: November 2020

The New Zealand Ministry of Health reported that respiratory disease affects 700,000 people, annually costs New Zealand NZ$7.05 billion, and is the third-highest cause of death. The hospitalisation rate for asthma of Māori communities is 2.0 higher than that of other ethnic groups, and hospitalisation rates for deprived homes are 2.3 times higher than those of the least deprived homes. Based on physical data and evidence, which were drawn from a mixed methodology that includes field studies of the indoor microclimate, dust-mite allergens, mould growth, and occupants’ Respiratory Health Survey of a number of sample houses of Māori communities in Minginui, Te Whaiti, Murupara, and Rotorua of New Zealand, the study identifies unhealthy indoor thermal conditions, thresholds or ranges of indoor micro-climate related to different levels of dust-mite allergen and mould growth, the most common type of indoor mould, and correlations between dust-mite and mould and correlations. The study not only identified that the poor health of occupants is closely related to their inadequate living conditions, but also identifies the threshold of indoor micro-climates to maintain indoor allergens at the acceptable level, which can be used as a guideline to maintain or improve indoor health conditions for future housing development or retrofitted old housing.
Self-Medication-Related Behaviors and Poland’s COVID-19 Lockdown
Authors: Makowska Marta , Boguszewski Rafał , Nowakowski Michał , Podkowińska Monika
Published: November 2020

(1) Background: The SARS-CoV-2 pandemic has changed the functioning of Polish health systems. Telemedicine has been developed and access to prescription drugs (Rx) has been facilitated. This study examined whether these changes and the imposition of a three-month lockdown caused Polish people to engage in more self-medication-related behaviors. (2) Method: After the fourth (final) stage of defrosting the Polish economy, an online survey of a quota sample of 1013 Polish respondents was conducted. (3) Results: Almost half of the respondents (45.6%) indicated that they had engaged in at least one behavior associated with inappropriate self-medication during the lockdown (e.g., 16.6% took medication as a precaution, and 16.8% took an Rx formulation without consultation). Some of these people had never engaged in such behaviors prior to the lockdown. Linear regression showed that higher values of a composite (“lockdown”) index of self-medication-related behaviors occurring during lockdown were predicted by greater religiosity and the presence of children in a household. Also, independent samples t-tests showed that people who were afraid for their financial future and people who feared for their health obtained higher lockdown index scores than people not having such worries. (4) Conclusions: Self-medication-related behaviors were more common among Poles before lockdown than during the lockdown (which is unsurprising given that the lengths of the periods compared were hugely different), worryingly, many people exhibited such behaviors for the first time during the lockdown.
INFERENCE: An Evidence-Based Approach for Medicolegal Causal Analyses
Authors: Meilia Putri Dianita Ika , Zeegers Maurice P. , Herkutanto  , Freeman Michael
Published: November 2020

A fundamental purpose of forensic medical, or medicolegal, analysis is to provide legal factfinders with an opinion regarding the causal relationship between an alleged unlawful or negligent action and a medically observed adverse outcome, which is needed to establish legal liability. At present, there are no universally established standards for medicolegal causal analysis, although several different approaches to causation exist, with varying strengths and weaknesses and degrees of practical utility. These approaches can be categorized as intuitive or probabilistic, which are distributed along a spectrum of increasing case complexity. This paper proposes a systematic approach to evidence-based assessment of causation in forensic medicine, called the INtegration of Forensic Epidemiology and the Rigorous EvaluatioN of Causation Elements (INFERENCE) approach. The INFERENCE approach is an evolution of existing causal analysis methods and consists of a stepwise method of increasing complexity. We aimed to develop a probabilistic causal analysis approach that (1) fits the needs of legal factfinders who require an estimate of the probability of causation, and (2) is still sufficiently straightforward to be applied in real-world forensic medical practice. As the INFERENCE approach is most relevant in complex cases, we also propose a process for selecting the most appropriate causal analysis method for any given case. The goal of this approach is to improve the reproducibility and transparency of causal analyses, which will promote evidence-based practice and quality assurance in forensic medicine, resulting in expert opinions that are reliable and objective in legal proceedings.
Association between Overweight, Obesity and the Prevalence of Multimorbidity among the Elderly: Evidence from a Cross-Sectional Analysis in Shandong, China
Authors: Hu Fangfang , Xu Lingzhong , Zhou Jinling , Zhang Jiao , Gao Zhaorong , Hong Zhuang
Published: November 2020

(1) Background: Multimorbidity, defined as the occurrence of two or more chronic diseases, is a global public health problem which has a significant negative impact on individuals, families and the society. The aim of this study was to evaluate the association between overweight, obesity and the prevalence of multimorbidity among male and female older adults; (2) Methods: Cross-sectional data of the 7070 participants from China, aged 60 years and above included in 2017 the Shandong Elderly Family Health Service Survey were analyzed. Multivariate logistic regression analysis was used to examine the relationship between overweight, obesity and the prevalence of multimorbidity in males and females; (3) Results: Among the 7070 participants, of which 40.25% were males and 59.75% were females, the average age of all participants was (69.81 ± 6.45) years old. The prevalence of multimorbidity in older adults was 34.71%, and the overweight and obesity rates were 39.25% and 16.89%. Among the male elderly, the likelihood of multimorbidity was more than two times higher among the obese than the normal BMI population (OR: 2.14; 95%CI: 1.63–2.82). A less strong association was found in the overweight male older population (OR: 1.43; 95%CI: 1.18–1.74). In the females, compared with individuals with normal BMI, the risks for incident multimorbidity were high in the overweight and obese groups, with odds ratios of 1.42 (95%CI: 1.21–1.65) and 1.81 (95%CI: 1.51–2.17), respectively. (4) Conclusions: In this study, overweight and obesity had the strongest association with the prevalence of multimorbidity among Chinese older adults, and the associations were different between the male and female elderly. The prevalence of multimorbidity might be effectively prevented by controlling body mass index. Encouraging the elderly to eat the recommended amount of vegetables and fruits, walk at least 30 min a day and have enough sleep to maintain a healthy weight.
Quantification of the Aluminum Content Leached into Foods Baked Using Aluminum Foil
Authors: Fermo Paola , Soddu Gabriele , Miani Alessandro , Comite Valeria
Published: November 2020

In this study, determinations of the aluminum content in meat and fish performed after having cooked these foods using commercially available aluminum foil have been performed. The release of this chemical element was evaluated by cooking beef, chicken, and fish wrapped with commercial aluminum foil using seasoning or without seasoning in order to evaluate the effect on Al leaching into the food. The characterization of the food samples was carried out using two different analytical methods: inductively coupled plasma optical emission spectrometry (ICP-OES), for the quantification of aluminum, and scanning electron microscopy coupled with energy dispersion spectroscopy (SEM-EDS) to evaluate any structural changes occurring inside the aluminum foil after the cooking procedure. It has been demonstrated that the leaching that occurs when the foods are cooked by wrapping them in Al foil is not negligible and that the consumption of these foods, together with the consumption of other foodstuffs, such as, for example, some vegetables that may naturally contain aluminum, can lead to consuming a weekly dose not far from the TWI (tolerable weekly intake).
Change-of-Direction Performance in Elite Soccer Players: Preliminary Analysis According to Their Playing Positions
Authors: Sariati Dorsaf , Hammami Raouf , Chtara Mokhtar , Zagatto Alessandro , Boullosa Daniel , Clark Cain C. T. , Hackney Anthony C. , Granacher Urs , Souissi Nizar , Zouhal Hassane
Published: November 2020

Our objective was to examine the relationship between change of direction (CoD) performance, with (CoDb), and without the ball (CoDwb), and selected measures of physical fitness (jump performance, speed, balance) in elite soccer players, according to players’ positions. Forty elite male soccer players performed the change-of-direction and acceleration test (CODAT) with (CODATb), and without the ball (CODATwb), 5- and 20-m sprint tests, the 5-jump test (5JT), and the Y-balance test (YBT). Analyses of the whole sample showed significant correlations between all CODAT measures (CODATwb and CODATb, respectively) and sprint 5-m (r = 0.72, p < 0.001; r = 0.52, p < 0.01), sprint 20-m (r = 0.54, p < 0.03; r = 0.45, p < 0.05), jump (r = −0.62, p < 0.01; r = −0.64, p < 0.01) and balance (r = −0.50, p < 0.01; r = −0.83, p < 0.001) performances. Correlations were significantly different between player positions (defender, midfielder and striker). When examining the entire sample, the single best predictor of CODATwb was performance in the 5-m test with an explained variance of 52% (p < 0.001). For CODATb, the Y-balance performance explained 68% of the variance of performance (p < 0.001). In conclusion, soccer coaches and fitness trainers are advised to improve players’ CoD using neuromuscular training that mimic crucial match actions. Meanwhile, CoD testing and training should be designed in line with the demands of playing position.
Clinical Characteristics and Survival Analysis in a Small Sample of Older COVID-19 Patients with Defined 60-Day Outcome
Authors: Neumann-Podczaska Agnieszka , Chojnicki Michal , Karbowski Lukasz M. , Al-Saad Salwan R. , Hashmi Abbas A. , Chudek Jerzy , Tobis Slawomir , Kropinska Sylwia , Mozer-Lisewska Iwona , Suwalska Aleksandra , Tykarski Andrzej , Wieczorowska-Tobis Katarzyna
Published: November 2020

The older population is one of the most vulnerable to experience adverse outcomes of COVID-19. Exploring different clinical features that may act as detrimental to this population’s survival is pivotal for recognizing the highest risk individuals for poor outcome. We thus aimed to characterize the clinical differences between 60-day survivors and non-survivors, as well as analyze variables influencing survival in the first older adults hospitalized in Poznan, Poland, with COVID-19. Symptoms, comorbidities, complications, laboratory results, and functional capacity regarding the first 50 older patients (≥60 years) hospitalized due to COVID-19 were retrospectively studied. Functional status before admission (dependent/independent) was determined based on medical history. The 60-day survivors (n = 30/50) and non-survivors (n = 20/50) were compared across clinical parameters. The patients had a mean age of 74.8 ± 9.4 years. Overall, 20/50 patients died during hospitalization, with no further fatal outcomes reported during the 60-day period. The non-survivors were on average older (78.3 ± 9.7 years), more commonly experienced concurrent heart disease (75%), and displayed functional dependence (65%) (p < 0.05). When assessing the variables influencing survival (age, heart disease, and functional dependence), using a multivariate proportional hazards regression, functional dependence (requiring assistance in core activities of daily living) was the main factor affecting 60-day survival (HR, 3.34; 95% CI: 1.29–8.63; p = 0.01). In our study, functional dependence was the most important prognostic factor associated with mortality. Elderly with COVID-19 who required assistance in core activities of daily living prior to hospitalization had a three times increased risk to experience mortality, as compared to those with complete independence. Exploring geriatric approaches, such as assessment of functional capacity, may assist in constructing comprehensive survival prognosis in the elderly COVID-19 population.
Understanding the Relationship between Environmental Arsenic and Prostate Cancer Aggressiveness among African-American and European-American Men in North Carolina
Authors: Parada Humberto , Wu Tianying , Fry Rebecca C. , Farnan Laura , Smith Gary J. , Mohler James L. , Bensen Jeannette T.
Published: November 2020

High-level exposure to arsenic, a known carcinogen and endocrine disruptor, is associated with prostate cancer (PCa) mortality. Whether low-level exposure is associated with PCa aggressiveness remains unknown. We examined the association between urinary arsenic and PCa aggressiveness among men in North Carolina. This cross-sectional study included 463 African-American and 491 European-American men with newly diagnosed, histologically confirmed prostate adenocarcinoma. PCa aggressiveness was defined as low aggressive (Gleason score < 7, stage = cT1–cT2, and PSA < 10 ng/mL) versus intermediate/high aggressive (all other cases). Total arsenic and arsenical species (inorganic arsenic (iAsIII + iAsV), arsenobetaine, monomethyl arsenic, and dimethyl arsenic)) and specific gravity were measured in spot urine samples obtained an average of 23.7 weeks after diagnosis. Multivariable logistic regression was used to estimate the covariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for PCa aggressiveness in association with arsenic tertiles/quantiles overall and by race. The highest (vs. lowest) tertile of total arsenic was associated with PCa aggressiveness ORs of 1.77 (95% CI = 1.05–2.98) among European-American men, and 0.94 (95% CI = 0.57–1.56) among African-American men (PInteraction = 0.04). In contrast, total arsenic and arsenical species were not associated with PCa aggressiveness in unstratified models. Low-level arsenic exposure may be associated with PCa aggressiveness among European-Americans, but not among African-Americans.
Role of qSOFA and SOFA Scoring Systems for Predicting In-Hospital Risk of Deterioration in the Emergency Department
Authors: López-Izquierdo Raúl , Brio-Ibañez Pablo del , Martín-Rodríguez Francisco , Mohedano-Moriano Alicia , Polonio-López Begoña , Maestre-Miquel Clara , Viñuela Antonio , Durantez-Fernández Carlos , Villamor Miguel Á. Castro , Martín-Conty José L.
Published: November 2020

The objective of this study was to analyze and compare the usefulness of quick sequential organ failure assessment score (qSOFA) and sequential organ failure assessment (SOFA) scores for the detection of early (two-day) mortality in patients transported by emergency medical services (EMSs) to the emergency department (ED) (infectious and non-infectious). We performed a multicentric, prospective and blinded end-point study in adults transported with high priority by ambulance from the scene to the ED with the participation of five hospitals. For each score, the area under the curve (AUC) of the receiver operating characteristic (ROC) curve was calculated. We included 870 patients in the final cohort. The median age was 70 years (IQR 54–81 years), and 338 (38.8%) of the participants were women. Two-day mortality was 8.3% (73 cases), and 20.9% of cases were of an infectious pathology. For two-day mortality, the qSOFA presented an AUC of 0.812 (95% CI: 0.75–0.87; p < 0.001) globally with a sensitivity of 84.9 (95% CI: 75.0–91.4) and a specificity of 69.4 (95% CI: 66.1–72.5), and a SOFA of 0.909 (95% CI: 0.86–0.95; p < 0.001) with sensitivity of 87.7 (95% CI: 78.2–93.4) and specificity of 80.7 (95% CI: 77.4–83.3). The qSOFA score can serve as a simple initial assessment to detect high-risk patients, and the SOFA score can be used as an advanced tool to confirm organ dysfunction.
Network Analysis of the Social Environment Relative to Preference for and Tolerance of Exercise Intensity in CrossFit Gyms
Authors: Patterson Megan S. , Heinrich Katie M. , Prochnow Tyler , Graves-Boswell Taylor , Spadine Mandy N.
Published: November 2020

Known for its ability to improve fitness and health, high-intensity functional training (HIFT) focuses on functional movements completed at high intensities, often yielding outcomes superior to repetitive aerobic workouts. Preference for and tolerance of high-intensity exercise are associated with enjoyment of and adherence to HIFT. Similarly, the social environment present within CrossFit, a popular group-based HIFT modality, is important to the enjoyment of and adherence to HIFT. This study aimed to test whether preference and tolerance were related to social connections within CrossFit networks. Linear network autocorrelation models (LNAMs) and exponential random graph models (ERGMs) were computed on sociometric and attribute data from members of three CrossFit networks (n = 197). LNAMs showed the preference and tolerance scores of someone’s social connections were associated with their own in all three gyms, and ERGMs demonstrated preference and tolerance scores were associated with the presence of social ties within all networks. This study is the first to provide evidence for a relationship between social connections and preference and tolerance. Future longitudinal research is needed to determine if the social environment may influence and optimize a person’s preference of and tolerance for HIFT.
Study Protocol for Two-Steps Parallel Randomized Controlled Trial: Pre-Clinical Usability Tests for a New Double-Chamber Syringe
Authors: Parreira Pedro , Sousa Liliana B. , Marques Inês A. , Santos-Costa Paulo , Cortez Sara , Carneiro Filipa , Cruz Arménio , Salgueiro-Oliveira Anabela
Published: November 2020

A new double-chamber syringe (DUO Syringe) was developed for intravenous drug administration and catheter flushing. This study presents a protocol for pre-clinical usability tests to validate the golden prototype of this new device, performed in a high-fidelity simulation lab by nurses. A two-steps parallel randomized controlled trial with two arms was designed (with standard syringes currently used in clinical practice and with the DUO Syringe). After randomization, eligible and consented participants will be requested to perform, individually, intravenous drug administration and flushing, following the arm that has been allocated. The procedure will be video-recorded for posterior analyses. After the completion of the tasks, nurses will be asked to answer a demographic survey, as well as an interview about their qualitative assessment of the device. A final focus group with all participants will also be conducted. Primary outcomes will concern the DUO Syringe’s effectiveness, efficiency, and safety, while secondary outcomes will focus on nurses’ satisfaction and intention of use. The pre-clinical protocol was defined according to the legal requirements and ISO norms and was reviewed and approved by the Ethics Committee of the Health Sciences Research Unit: Nursing of the Nursing School of Coimbra.
Efficient Removal 17-Estradiol by Graphene-Like Magnetic Sawdust Biochar: Preparation Condition and Adsorption Mechanism
Authors: Zhou Yahui , Liu Shaobo , Liu Yunguo , Tan Xiaofei , Liu Ni , Wen Jun
Published: November 2020

The occurrence of environmental endocrine disrupting chemicals (EDCs) in aquatic environments has caused extensive concern. Graphene-like magnetic sawdust biochar was synthesized using potassium ferrate (K2FeO4) to make activated sawdust biochar and applied for the removal of 17-estradiol (E2). The characterization showed that the surface morphology of five graphene-like magnetic sawdust biochars prepared with different preparation conditions were quite different. The specific surface area and pore structure increased with the increment of K2FeO4 addition. The results have shown that graphene-like magnetic sawdust biochar (1:1/900 °C) had the best removal on E2. The experimental results indicated that pseudo-first-order kinetic model and the Langmuir model could describe the adsorption process well, in which the equilibrium adsorption capacity (qe,1) of 1:1/900 °C were 59.18 mg·g−1 obtained from pseudo-first-order kinetic model and the maximum adsorption capacity (qmax) of 1:1/900 °C were 133.45 mg·g−1 obtained from Langmuir model at 298K. At the same time, lower temperatures, the presence of humic acid (HA), and the presence of NaCl could be regulated to change the adsorption reaction in order to remove E2. Adsorption capacity was decreased with the increase of solution pH because pH value not only changed the surface charge of graphene-like magnetic sawdust biochar, but also affected the E2 in the water. The possible adsorption mechanism for E2 adsorption on graphene-like magnetic sawdust biochar was multifaceted, involving chemical adsorption and physical absorption, such as H-bonding, π-π interactions, micropore filling effects, and electrostatic interaction. To sum up, graphene-like magnetic sawdust biochar was found to be a promising absorbent for E2 removal from water.
Physiological Responses of Intrinsic Small Abalone Haliotis diversicolor aquatilis under High Temperature Stress by Low Level 60CO Gamma Irradiation-Mediated Hormetic Effect
Authors: Jwa Min-seok , Hong Chang-Yu
Published: November 2020

Haliotis diversicolor aquatilis (H. diversicolor aquatilis) is one of the aquaculture abalone species in Jeju Island, South Korea. The high water temperature in the middle of the summer season frequently limits the aquaculture productivity of abalone. To cope with the problem, this study aimed to investigate viability, attachment rate, changes of immune response, and physiological properties of juvenile small abalone Haliotis diversicolor aquatilis against high water temperature stress under 60CO-gamma irradiation-mediated hormetic effects. To examine physiological changes of abalone, the gamma-ray irradiated and non-irradiated groups were distinguished by grouping a total of 70 abalones in a treated group and a control group (each group included twenty-five female and ten male abalones). The treated group was exposed to 60CO-gamma irradiation using a designed experimental apparatus, the control group was not. Our results revealed that the low level of gamma ray (20 Gy)-irradiated Haliotis diversicolor aquatilis showed a 100% survival rate during the experiment. After gamma ray exposure, all the abalones were cultured without feeding and bioactivities were measured to examine gamma ray-induced physiological responses. The results suggested the potential for selective breeding using gamma ray irradiation hormesis to manipulate the number of eggs, fertilization rate, hatching rate, and attachment rate. The shell length of juvenile abalone was significantly enhanced by a 20 Gy radiation dose. We could presume that the effect of hormesis in the gamma-ray irradiation parent shellfish also had a genetic effect on the offspring. In order to verify changes in immune response and stress tolerance of abalone under high temperature stress, lysozyme activity and survival rates were compared at a water temperature of 30 °C. Interestingly, the 60Co gamma ray-irradiated abalones exhibited almost a 1.65-fold enhanced survival rate along with reduced lysozyme activity after 12 h of high temperature stress. Our results speculate that low levels of 60Co gamma ray-mediated hormetic effects can be an effective strategy for shell length growth and high temperature stress tolerance.
China’s Environmental Vertical Management Reform: An Effective and Sustainable Way Forward or Trouble in Itself?
Authors: Zhou Di
Published: November 2020

An environmental management system provides the institutional foundation for sound environmental governance. Conventional environmental management systems, deriving from the combination of the vertical management of competent authorities and the localized management of local governments, can lead to local protectionism and implementation deviation at the local level. Since 2016, environmental vertical management reform has been performed as a significant part of the overall promotion of the ecological civilization in China. Representing the most fundamental reform of China’s local environmental management system since the Environmental Protection Law of 1989, the environmental vertical management reform focuses on the reconstruction and adjustment of the environmental management functions among the local governments, and their environment protection authorities at the provincial, city, and county levels. In this paper, we provide an overview of the basic theory of the vertical management model, as well as the motivation for—and the legal/policy background, focuses/content, local practices, and results of—the environmental vertical management reform in China. In the discussion section, we analyze the current problems that impede the effectiveness and sustainability of this reform. On the basis of the analysis of the present and the problems, we raise the question of whether this round of reform is effective and will be sustainable in the future. In response to the challenges, feasible recommendations are proposed. These suggestions include firmly promoting the rule of law in the process of implementing the reform, enhancing the institutional supply and capacity building at the grassroots level, and taking advantage of the holistic governance under the leadership of the Communist Party of China (CPC).
Selected Physicochemical Properties of Diamond Like Carbon (DLC) Coating on Ti-13Nb-13Zr Alloy Used for Blood Contacting Implants
Authors: Antonowicz Magdalena , Kurpanik Roksana , Walke Witold , Basiaga Marcin , Sondor Jozef , Paszenda Zbigniew
Published: November 2020

Despite high interest in the issues of hemocompatibility of titanium implants, particularly those made of the Ti-13Nb-13Zr alloy, the applied methods of surface modification still do not always guarantee the physicochemical properties required for their safe operation. The factors that reduce the efficiency of the application of titanium alloys in the treatment of conditions of the cardiovascular system include blood coagulation and fibrous proliferation within the vessel’s internal walls. They result from their surfaces’ physicochemical properties not being fully adapted to the specifics of the circulatory system. Until now, the generation and development mechanics of these adverse processes are not fully known. Thus, the fundamental problem in this work is to determine the correlation between the physicochemical properties of the diamond like carbon (DLC) coating (shaped by the technological conditions of the process) applied onto the Ti-13Nb-13Zr alloy designed for contact with blood and its hemocompatibility. In the paper, microscopic metallographic, surface roughness, wettability, free surface energy, hardness, coating adhesion to the substrate, impendence, and potentiodynamic studies in artificial plasma were carried out. The surface layer with the DLC coating ensures the required surface roughness and hydrophobic character and sufficient pitting corrosion resistance in artificial plasma. On the other hand, the proposed CrN interlayer results in better adhesion of the coating to the Ti-13Nb-13Zr alloy. This type of coating is an alternative to the modification of titanium alloy surfaces using various elements to improve the blood environment’s hemocompatibility.
Analysis of the Part Distortions for Inconel 718 SLM: A Case Study on the NIST Test Artifact
Authors: Martínez Silvia , Ortega Naiara , Celentano Diego , Sánchez Egea Antonio J. , Ukar Eneko , Lamikiz A.
Published: November 2020

The present paper evaluates the misalignment and geometry distortion of the standard National Institute of Standards and Technology (NIST) test artifact in Inconel 718 alloy, when several layers with and without supports are employed to manufacture it by the Selective Laser Melting (SLM) process. To this end, a coordinate-measuring machine (CMM) is used to measure the geometrical distortion in each manufacturing configuration, following the same measurement protocol. The results show that the laser path strategy favors a thermal gradient which, consequently, induces geometrical distortions in the part. To prove this hypothesis, a numerical simulation is performed to determine the thermal gradient and the pattern of the residual stresses. It was found that the geometrical distortion certainly depends on the position of the feature position and laser strategy, where thermal cycles and residual thermal stresses had an impact in the end-part geometry, especially if a high strength-to-weight ratio commonly used in aeronautics is present.
The Formation of Perovskite during the Combustion of an Energy-Rich Glycine–Nitrate Precursor
Authors: Komova Oksana , Mukha Svetlana , Ozerova Anna , Odegova Galina , Simagina Valentina , Bulavchenko Olga , Ishchenko Arcady , Netskina Olga
Published: November 2020

The effect of different regimes of combustion of glycine–nitrate precursors on the formation of perovskite phases (LaMnO3 and LaCrO3) without additional heat treatment was studied. The following three combustion regimes were compared: the traditional solution combustion synthesis (SCS), volume combustion synthesis (VCS) using a powdered precursor, and self-propagating high-temperature synthesis (SHS) using a precursor pellet. The products of combustion were studied using a series of physicochemical methods (attenuated total reflection infrared spectroscopy (ATR FTIR), X-ray diffraction (XRD), high-resolution transmission electron microscopy (HRTEM), and thermal analysis). SHS was found to be the most productive regime for the formation of perovskite because of its ability to develop high temperatures in the reaction zone, which led to a reduced content of the thermally stable lanthanum carbonate impurities and to an increased yield and crystallite size of the perovskite phase. The reasons for the better crystallinity and purity of LaCrO3 as compared with LaMnO3 is also discussed, namely the low temperatures of the onset of the thermolysis, the fast rate of combustion, and the favorable thermodynamics for the achievement of high temperatures in the reaction zone.
Mechanical Characterisation of Single-Walled Carbon Nanotube Heterojunctions: Numerical Simulation Study
Authors: Pereira André F. G. , Antunes Jorge M. , Fernandes José V. , Sakharova Nataliya
Published: November 2020

The elastic properties of single-walled carbon nanotube heterojunctions were investigated using conventional tensile, bending and torsion tests. A three-dimensional finite element model was built in order to describe the elastic behaviour of cone heterojunctions (armchair–armchair and zigzag–zigzag). This comprehensive systematic study, to evaluate the tensile, bending and torsional rigidities of heterojunctions, enabled the formulation analytical methods for easy assessment of the elastic properties of heterojunctions using a wide range of their geometrical parameters.
Impact of Acidity Profile on Nascent Polyaniline in the Modified Rapid Mixing Process—Material Electrical Conductivity and Morphological Study
Authors: Golba Sylwia , Popczyk Magdalena , Miga Seweryn , Jurek-Suliga Justyna , Zubko Maciej , Kubisztal Julian , Balin Katarzyna
Published: November 2020

Polyaniline (PANI) was synthesized chemically with the modified rapid mixing protocol in the presence of sulfuric acid of various concentrations. A two-step synthetic procedure was utilized maintaining low-temperature conditions. Application of the modified rapid mixing protocol allowed obtaining a material with local ordering. A higher concentration of acid allowed obtaining a higher yield of the reaction. Structural characterization performed with Fourier-transform infrared (FTIR) analysis showed the vibration bands characteristic of the formation of the emeraldine salt in both products. Ultraviolet–visible light (UV–Vis) spectroscopy was used for the polaronic band and the p–p* band determination. The absorption result served to estimate the average oxidation level of PANI by comparison of the ratio of the absorbance of the polaronic band to that of the π–π* transition. The absorbance ratio index was higher for PANI synthesized in a more acidic solution, which showed a higher doping level for this polymer. For final powder products, particle size distributions were also estimated, proving that PANI (5.0 M) is characterized by a larger number of small particles; however, these particles can more easily agglomerate and form larger structures. The X-ray diffraction (XRD) patterns revealed an equilibrium between the amorphous and semicrystalline phase in the doped PANI. A higher electrical conductivity value was measured for polymer synthesized in a higher acid concentration. The time-of-flight secondary ion mass spectrometry (TOF-SIMS) analysis showed that the molecular composition of the polymers was the same; hence, the difference in properties was a result of local ordering.
Particle Focusing under Newtonian and Viscoelastic Flow in a Straight Rhombic Microchannel
Authors: Kwon Joo-Yong , Kim Taehoon , Kim Jungwoo , Cho Younghak
Published: November 2020

Particle behavior in viscoelastic fluids has attracted considerable attention in recent years. In viscoelastic fluids, as opposed to Newtonian fluids, particle focusing can be simply realized in a microchannel without any external forces or complex structures. In this study, a polydimethylsiloxane (PDMS) microchannel with a rhombic cross-sectional shape was fabricated to experimentally investigate the behavior of inertial and elasto-inertial particles. Particle migration and behavior in Newtonian and non-Newtonian fluids were compared with respect to the flow rate and particle size to investigate their effect on the particle focusing position and focusing width. The PDMS rhombic microchannel was fabricated using basic microelectromechanical systems (MEMS) processes. The experimental results showed that single-line particle focusing was formed along the centerline of the microchannel in the non-Newtonian fluid, unlike the double-line particle focusing in the Newtonian fluid over a wide range of flow rates. Numerical simulation using the same flow conditions as in the experiments revealed that the particles suspended in the channel tend to drift toward the center of the channel owing to the negative net force throughout the cross-sectional area. This supports the experimental observation that the viscoelastic fluid in the rhombic microchannel significantly influences particle migration toward the channel center without any external force owing to coupling between the inertia and elasticity.
Advances in Optical Detection of Human-Associated Pathogenic Bacteria
Authors: Locke Andrea , Fitzgerald Sean , Mahadevan-Jansen Anita
Published: November 2020

Bacterial infection is a global burden that results in numerous hospital visits and deaths annually. The rise of multi-drug resistant bacteria has dramatically increased this burden. Therefore, there is a clinical need to detect and identify bacteria rapidly and accurately in their native state or a culture-free environment. Current diagnostic techniques lack speed and effectiveness in detecting bacteria that are culture-negative, as well as options for in vivo detection. The optical detection of bacteria offers the potential to overcome these obstacles by providing various platforms that can detect bacteria rapidly, with minimum sample preparation, and, in some cases, culture-free directly from patient fluids or even in vivo. These modalities include infrared, Raman, and fluorescence spectroscopy, along with optical coherence tomography, interference, polarization, and laser speckle. However, these techniques are not without their own set of limitations. This review summarizes the strengths and weaknesses of utilizing each of these optical tools for rapid bacteria detection and identification.
Mediterranean Personalized Diet Combined with Physical Activity Therapy for the Prevention of Cardiovascular Diseases in Italian Women
Authors: Di Renzo Laura , Cinelli Giulia , Dri Maria , Gualtieri Paola , Attinà Alda , Leggeri Claudia , Cenname Giuseppe , Esposito Ernesto , Pujia Alberto , Chiricolo Gaetano , Salimei Chiara , De Lorenzo Antonino
Published: November 2020

Cardiovascular diseases (CVDs) and inflammatory risk indexes are used to calculate the exposure to morbidity. Most of them are suggested by the American College of Cardiology/American Heart Association to predict the risk of CVDs diagnosis in primary prevention, instead of treating the ongoing pathology. Prevention starts from habit changes with the prescription of diet and physical activity (PA). The aim of the study is to investigate the effectiveness of a personalized Mediterranean Diet (MD) and a PA intervention, on the risk indexes Atherogenic Index of Plasma (AIP), Lipid Accumulation Product (LAP) and Fatty Liver Index (FLI) in a population of women at risk of CVDs with different pathological conditions. After treatment, patients achieved the best results in body composition (BC) and laboratory tests. The BC analysis showed a significant reduction of total body Fat Mass (FM). CVDs risk indexes significantly decreased, except for Neutrophil/Lymphocyte (NLR) and Platelet/Lymphocyte Ratios (PLR). The reduction of the CVDs indexes associated with lipid profile was linked to both weight and FM decrease. AIP and LAP were significantly reduced when losing fat mass and body weight, respectively. A personalized MD therapy plus a PA program led to body weight loss, BC remodelling and risk indexes reduction.
Vitamins in Alzheimer’s Disease—Review of the Latest Reports
Authors: Mielech Anita , Puścion-Jakubik Anna , Markiewicz-Żukowska Renata , Socha Katarzyna
Published: November 2020

Alzheimer’s disease (AD) is the most common form of dementia, and the aging of the population means that the number of cases is successively increasing. The cause of the disease has not been established, but it is suggested that many factors affect it, including nutritional aspects. As part of the work, the PubMed database has been searched, beginning from 2005, for terms related to key nutritional aspects. A diet rich in antioxidant vitamins can improve the cognitive functions of patients. Thanks to an adequate intake of B vitamins, homocysteine levels are reduced, which indirectly protects against the development of the disease. A properly balanced diet, as well as the use of appropriate supplementation, can contribute to improving the clinical condition of patients with AD.
Omega-3 Eicosapentaenoic Acid Is Related to Happiness and a Sense of Fulfillment—A Study among Female Nursing Workers
Authors: Tsuboi Hirohito , Sakakibara Hiroyuki , Matsunaga Masahiro , Tatsumi Asami , Yamakawa-Kobayashi Kimiko , Yoshida Naoko , Shimoi Kayoko
Published: November 2020

Background: Omega (ω) 3 fatty acid (FA) is a polyunsaturated FA (PUFA) that can modulate some mental statuses. However, most studies have not considered the functional differences between eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). We investigated associations among happiness, a sense of fulfillment and serum ω3 PUFA levels. Methods: Participants were 133 female staff from a hospital and nursing homes. Happiness was measured using the Japanese version of the subjective happiness scale (SHS); a sense of fulfillment was assessed using a visual analogue scale. Serum FA concentrations were measured. A partial correlation test and a regression model were applied. Results: The SHS scores showed significantly positive correlations with a sense of fulfillment, DHA% and EPA% (p < 0.05, < 0.05 and < 0.005, respectively), after controlling for age, BMI, menopause, snacking habits and leisure-time physical activities. A sense of fulfillment was significantly negatively correlated with α-linoleic acid%, and positively correlated with DHA% and EPA% (p < 0.05, < 0.05 and < 0.005, respectively), after controlling for the confounders. A regression model showed that a sense of fulfillment, EPA, and not stopping menstruation explained happiness (standardised beta, B = 0.18, p < 0.05; B = 0.24, p < 0.01; and B = 0.32, and p < 0.05, respectively), whereas age, BMI and snacking habits could not. Simultaneously, a regression model could not explain the association between DHA and happiness. Conclusion: Happiness was related with serum EPA%, a sense of fulfillment, and premenopause.
Variation in Infant Formula Macronutrient Ingredients Is Associated with Infant Anthropometrics
Authors: Young Bridget
Published: November 2020

Background: There is wide variation in the macronutrient ingredient base of infant formula. How variation in macronutrient ingredients may impact infant growth remains largely unknown. Methods: The 2015–2016 National Health and Nutrition Examination Survey (NHANES) dataset was utilized, including infant anthropometrics and dietary intake. The protein, fat, and carbohydrate sources of formulas consumed were assembled and considered as potential predictors in multivariable models of infant Z-scores among infants < 6 months, 6–12 months and all infants combined (0–12 months). Results: The following relationships represent ingredient covariates within the final multivariable models of infant Z-scores. Consuming formula with palm oil was associated with higher weight-for-length Z-scores among infants < 6 months, but lower weight-for-age and weight-for-length Z-scores among infants 6–12 months. Consuming soy-protein formulas was associated with lower weight-for-length, head circumference-for-age and abdominal circumference-for-age Z-scores among infants < 6 months. Consuming sucrose-containing formula was associated with higher weight-for-length and abdominal circumference-for-age Z-score among infants 0–12 months. Conclusions: These data provide proof-of-concept that all formulas are not the same. Variation in macronutrient ingredients within the standard formula category is associated with differences in infant anthropometric outcomes. Long-term and mechanistic studies are warranted to pursue these findings; especially for palm oil, soy protein, and sucrose.