bluuebunny/crossref_metadata_2025 huggingface dataset:
Ensuring Security in Crisis: Risk Mitigation Strategies and Response Planning
Authors: Andrii Rohulia
Published: February 2025

Introduction: National security is ensured through the formation and implementation of strategic management policy. The process is aimed primarily at overcoming risks and threats, preventing them and recurrence. Security management is particularly relevant in the current crisis conditions caused by the Russian invasion of Ukraine, external pressure and instability in all areas of national security.
Objectives: The study aims to theoretically analyse and formulate practical recommendations on national security management in a crisis in the context of strategies and mechanisms for ensuring it.
Methods: It uses several scientific methods, including systemic and economic analysis, synthesis, comparison and scientific abstraction, statistical methods (regression and correlation analysis), K-means and multivariate cluster analysis.
Results: The article examines the types of crises likely to occur in the security sector both within society and in the context of external influence. It defines a “fragile state” as a consequence of a crisis in one or more national security subsystems. Among the methodologies for analysing the level of “fragility”, the research suggests the approach of the Peace Foundation, which measures the Fragile State Index. The latter covers the sectors of cohesion (security apparatus, fragmentation of elites, group grievances and divisions), economy (poverty, inequality and economic development, outflow of intellectual labour), politics (state legitimacy, public services, human rights and the rule of law) and society. It is determined that the Fragile State Index for Ukraine reached a critical value in 2023, which makes it necessary to effectively revise management strategies to counter threats in a crisis. Empirical data emphasise the importance of synergy of efforts and a high level of coordination to protect territorial integrity and national sovereignty in the context of the rapidly changing geopolitical situation. It is substantiated that the sustainability of national security is determined, in particular, by the level of integration of digital innovative risk management solutions. The study analyses the National Cyber Security Index (NCSI) cybersecurity rating of digital development and the specifics of integrated information security systems (IPS).
Conclusions: Thus, the study results are of practical value in improving the anti-crisis management paradigm in the field of national security, as well as in the formation of appropriate plans for responding to challenges and preventing risks.
Influence of Global Religious Routes on Holy Sites and Communities: Communication Approaches and Societal Structures in the Growth of Religious Tourism
Authors: Svitlana Panchenko
Published: February 2025

Introduction: The article examines the problem of preserving traditional values and cultural and natural heritage for development and transmission to future generations. Religious tourism aims to satisfy physical and spiritual needs and develop a person's cultural perception. Tourism helps a person to gain experience in cooperation with another culture and helps to gain experience in involvement with the place where he or she is, with its traditions.
Objectives: This study aims to determine the essential aspects of pilgrimage tourism to sacred places as a factor in the development of domestic tourism.
Methods: Our study examined pilgrimages to sacred places of holy springs and fonts. The article states the significance of the impact of religious tourism on the economy of individual countries and regions of the world, as well as religious centres. The article examines specific pilgrimage routes (Athos, Jerusalem) and explores their history and impact on social groups.
Results: The relevance of the theoretical understanding of this phenomenon is due to the current practice of tourism activities, which increasingly requires thoughtful approaches to its implementation, and the need to address methodological issues in determining the directions of further development of religious tourism. It is essential to consider religious tourism as a historical and cultural phenomenon, as it allows for a deeper understanding of its essence as one of the essential creative cultural factors. The analysis of sources leads to the following conclusion: religious tourism is divided into religious and cultural tourism, pilgrimage tourism and special pilgrimage. Many reasons have led to the evolution of these forms, but the main thing is that Christianity is directly related to Christian traditions and culture.
Conclusions: Thus, tourists who choose alternative tourism belong to different economic and age groups, emphasising the tourism industry's multicomponent nature. This allows us to build a media strategy for the development of religious tourism.
Integrative Strategies and Innovations in Managing Hospitality Businesses
Authors: Liliia Honchar
Published: February 2025

Introduction: The integration of differentiated management paradigms from classical to systemic and situational allows hospitality enterprises to effectively navigate and adapt to challenging market conditions and respond flexibly and quickly to external challenges. Implementation of adaptation strategies is a critical aspect of responding to the dynamic and competitive environment of the hospitality sector, where technological innovations and changes in consumer preferences constantly influence business management practices. Innovative approaches in the hospitality sector reflect the specific needs, financial capabilities, and market conditions of different types of establishments, and the importance of a multiparadigm approach to optimise adaptation strategies and develop hospitality innovation is evident.
Objectives: This research aims to analyse the impact of a multiparadigm approach to managing businesses in the hospitality sector on enterprises' adaptability to modern challenges. It will also examine innovative solutions and adaptive strategies that promote increased competitiveness, operational process optimisation, and customer satisfaction.
Methods: A study was conducted using descriptive statistics to identify specific features and characteristics of management strategies and innovative solutions in the hospitality sector. The data for the analysis were collected through a survey of hotel executives and hospitality managers using the MS Forms Pro platform.
Results: The analysis of the survey results showed that growing competition, changes in customer demands and the desire to increase revenues are the main factors that stimulate the introduction of innovations. It has been determined that international chain hotels are highly oriented towards these factors. At the same time, hostels and motels face more significant difficulties due to a limited resource base and less developed staff qualifications.
Conclusions: The practical value of the research is that the obtained results can be used to develop and implement innovative solutions and adaptive strategies in the hospitality sector, which will support the optimisation of management processes.
Legislative Measures for Safeguarding Land Ownership Rights as a National Asset During Martial Law
Authors: Nataliia Petrova
Published: February 2025

Introduction: The article examines the relevant legal aspects of protecting land ownership rights under martial law.
Objectives: This article aims to analyse the legal norms and mechanisms that regulate the protection of land ownership rights in emergencies and wartime and develop proposals for their improvement.
Methods: The research methods include a comparative legal analysis, a systematic approach, and an analysis of case law and the legislative framework under martial law.
Results: As a result of the study, critical legal gaps and risks were identified, namely political, social, economic, and legal ones related to martial law, which affect the protection of landowners' rights. The necessity of amending the current Ukrainian legislation regulating land relations is substantiated as an urgent need. First and foremost, it is crucial to ensure precise regulation of the rights of landowners in occupied territories, mainly through compensation mechanisms for loss or damage to property. The study's practical value lies in its potential application to improving the regulatory framework for protecting Ukraine's national wealth in crisis.
Conclusions: Article provides recommendations for improving the legislative framework under such challenging conditions, particularly considering the specifics of national wealth, which is of fundamental importance to Ukraine in martial law. This issue raises new challenges in land ownership protection, including temporary expropriation, control over the use of land resources, and the preservation of national assets.
The Influence of Russia's Self-Perception through the Genocide of Ukrainians on International Legal Systems
Authors: Davit Geperidze
Published: February 2025

Introduction: The article reveals the ways of Russia's self-identification through the genocide of the Ukrainian people and analyses their impact on the system of international legal relations. The relevance of the study is related to the fact that after Russia's full-scale invasion and de-occupation of a part of our country, it was found that Russia resorted to targeted actions aimed at destroying our people. Therefore, it is essential to determine how the genocide of the Ukrainian people was carried out, what methods were used, and how this affected the people's ability to resist the invaders.
Objectives: The article reveals the ways of Russia's self-identification through the genocide of the Ukrainian people and analyses their impact on the system of international legal relations. The essence of the concept of "genocide" and the main characteristics of this term are described.
Methods: Given that the enemy continues the genocide of the Ukrainian people in the temporarily occupied territories, it is necessary to determine how such actions of the enemy are reflected in the system of international legal relations.
Results: The study identifies the reflection of the genocide of a people in the legal documents regulating the protection of human rights. The formation of the essence of the concept of "genocide" in the historical dimension is characterised. The main stages of the genocide of the Ukrainian people are identified. The ways of self-identification of Russia through the genocide of the Ukrainian people are analysed. The place of mass murder and torture in the genocide of the Ukrainian people is revealed. Sexual violence is identified as one of the main ways of committing genocide. The role of forced deportations in the loss of the nation's identity is analysed.
Conclusions: Attention is drawn to massive strikes and shelling, destruction as a factor in the formation of unfavourable living conditions for the population. The impact of Russia's methods of self-identification on the system of international legal relations is described. The role of courts and tribunals in holding war criminals accountable is characterised.
Ukrainian Revolution of Dignity 2013–2014: Origins, Progress, and Impact on Society
Authors: Volodymyr Kotsiuk
Published: February 2025

Introduction: The analysis of the Euromaidan (Revolution of Dignity) events will remain relevant for a long time, both from a scientific and applied point of view. It was the events of November 2013 – February 2014 that laid the foundations for real, not just declared, reforms in Ukraine, shaped the modern Ukrainian nation and identity and demonstrated to the world the aspirations and capacity of the Ukrainian people to be subjective in history, present and future.
Objectives: The aim of the article is to analyse the unity of the milestone revolutionary events in the modern history of Ukraine, focusing on the Revolution of Dignity as a revolution of values and historical and cultural subjectivity of Ukrainians.
Methods: The methodological basis of the article is the method of critical analysis of scientific literature, the historical and comparative method, and the methods of analysis and synthesis.
Results: The main reasons for the revolutionary events were the usurpation of power by former President Viktor Yanukovych and his subsequent refusal to sign the Association Agreement with the European Union. This violation of the aspirations of the Ukrainian people caused a natural wave of protest that grew into the Revolution of Dignity. The Euromaidan was an expression of the will of the Ukrainian people regarding values, freedom of choice, dignity, respect for human beings, and the ability to express their opinions freely. Initially, it was Euromaidan itself which united student and civic activists. The authorities' violent actions against the protesters led to the growth of revolutionary sentiment and brought people to the streets to protest. Adopting dictatorial laws on January 16 2014, only intensified the popular resistance. The storming of Euromaidan by the security forces and the shooting of people on 18-22 February 2014 (the Heavenly Hundred) turned Euromaidan into a Revolution of Dignity. The Euromaidan events unfolded across Ukraine, involving around 10 million people directly or indirectly participating in the protests.
Conclusions: This massive scale and scope of protests demonstrated the powerful potential of Ukrainian society for genuine renewal, the development of civil society, and the readiness to defend its values, even in the face of an arduous struggle and external threats from the Russian Federation.
Developing A Machine Learning Model to Predict Medication Adherence in Chronic Disease Management
Authors: Sinha Rashmi , Kumar Sahu Kishor
Published: February 2025

In the healthcare industry, chronic disease prediction is crucial. It is crucial to diagnose the illness early. Large amounts of data are generated in computer science as a result of significant technological advancements. Many medical databases are created as clinical information networks advance. Data mining, the process of managing vast amounts of diverse data and extracting insights from it, has emerged as a crucial area of study. Early illness detection, patient treatment, and community services from huge data creation in the biomedical and healthcare communities are all benefited by the accurate analysis of medical data. Nowadays, one of the main areas of research is the management and extraction of knowledge from vast amounts of diverse data. Accurate processing of health data helps the biomedical and healthcare communities by improving patient care, early illness detection, and community services. However, analytical precision is reduced if medical data is not sufficiently consistent. For the domains of biomedical pattern recognition and master learning, the perception and diagnosis of chronic disease are guaranteed to be consistent. Additionally, the decision-making approach's goal is pushed. The study of high-dimensional, multi-modal biomedical data can be effectively addressed by machine learning. In computer science, chronic disease prediction is crucial. Early detection and prediction of chronic disease is crucial. The dataset for chronic obstructive pulmonary disease is used for analysis by the suggested model. Using supervised machine learning techniques such as Random Forest, Multiplayer Perceptron, Logistic Regression, Stochastic Gradient Descent, and XG boost, we provide a chronic obstructive pulmonary disease prediction system. Next, we examine classification techniques for predicting chronic diseases using a variety of criteria, such as accuracy, precision, sensitivity, ROC, and AUC.
Investigating Public Pharmacists' Awareness, Perspectives, and Functions in Pediatric Palliative Management: Facilitators and Obstacles
Authors: Agrawal Ashish , Chandrakar Kunal
Published: February 2025

Pain is a frequent issue, and the use of painkillers is widespread. Public Pharmacists (PP) serve as the main interfaces for patients and may significantly influence the direction of reasonable medication or unconventional pain treatment approaches. Nonetheless, there are no definitive academic programs or standardized norms to facilitate this position, and the awareness of this prospective job remains limited. This research investigated PP's awareness, perspectives, and functions in Pediatric Palliative Management (PPM) at Community-based Pharmacies (CbP) and Pharmaceutical Storefronts (PSs). An exploratory study was performed using SPSS version 25 to collect, analyze, and evaluate the information. The study further examined possible facilitators and obstacles and the application of current regulations. Of the 125 PPs solicited for the research, 100 consented to participate and submitted the survey responses. When evaluating alternative options, 37.2% concur that the exclusive use of analgesics and adjuvant medicines may successfully manage chronic pain, whereas a notable minority (28.1%) either dissent or maintain a neutral stance. Cognitive Behavioral Therapy (CBT) is extensively supported as an early intervention, with 52.8% of individuals in agreement and 17.2% in strong agreement, underscoring its acknowledgment as a non-pharmacological approach for chronic pain management. Ultimately, a significant majority (62.1%) of participants agree that the selection of painkillers should be predicated on pain severity, with 21.3% expressing a strong endorsement of this methodology.
Pharmacokinetics and pharmacodynamics of antimicrobial agents in pediatric patients: a prospective cohort study
Authors: Pandey Rashmi , Nirmal Chandu Himanshu
Published: February 2025

The treatment of bacterial infections requires the use of antimicrobial medicines. Among the medications we take the most frequently are antibiotics. The best way to administer these medicines has not been well understood until recently. Unfortunately, the rate at which new antibiotics are found has been slowing down as the number of multidrug-resistant pathogens in hospital and community settings has increased. This discovery highlights the importance of finding the best regimens to produce favorable clinical and microbiological results, but it also highlights the need to find regimens that will prevent the establishment of resistance pathogens. It is even more important to keep organisms receptive to currently existing medications, as it will take over ten years for doctors to obtain new agents for multidrug-resistant bacteria. Pharmacodynamics may be used to identify the pharmaceutical openness metric that is closely linked to the capacity to destroy living things and impede the spread of safe animal subpopulations.
Perioperative pharmacological management of pain and anxiety in pediatric surgical patients: a randomized controlled trial
Authors: Kumar Sahu Deepak , Srinivasa Rao Varri
Published: February 2025

Every year, millions of children in the US undergo outpatient surgery, and the great majority of them experience excruciating perioperative pain and anxiety. Behavioral preparation programs that focus on skill development and modeling, which are considered essential for optimal preparation, are no longer available to most children and families in the outpatient surgery setting. Additionally, what little preparation does occur is typically general rather than tailored to the unique characteristics of the child and family. Untreated anxiety and pain have a substantial impact on children's short- and long-term healing as well as their future interactions in the medical context. In order to fully evaluate the impact of distraction on preoperative anxiety, especially in pediatric patients, we conducted a randomised controlled experiment (RCT). This randomized controlled study (RCT) evaluates the safety and efficacy of pharmacological treatments for perioperative pain and anxiety in pediatric surgical patients. The study looks at how different drug regimens affect pain scores, anxiety levels, side effects, and recovery outcomes.
Pharmacokinetics and pharmacodynamics of medications used in children: a systematic review
Authors: Bharti Sao Dr. Rupali , Chandrakar Kunal
Published: February 2025

Which methylated xanthine is safe and effective for treating apnea of prematurity in underdeveloped nations is still up for debate. The majority of newborns in developing nations are small for gestational age. For both Appropriate for Gestational Age and Small for Gestational Age infants, many doctors use the same dosage of methylxanthines. In order to optimize the dosages of caffeine and aminophylline in preterm infants with apnea, population PKPD models for these drugs must be developed and qualified. The study also aimed to examine the safety and effectiveness of routine prescribed doses of aminophylline and caffeine for apnea of prematurity. Caffeine at the usual suggested dosages for treating preterm apnea can be maintained. Since postnatal age had a major impact on Vd, it was clear that time-related developmental factors had a considerable impact on the pharmacokinetics of aminophylline. Doses determined using mg/kg would be biased. The current study's calculated dose of aminophylline can be used as a substitute for the commonly advised dosage. Comparative evaluation indicates that caffeine and aminophylline are similarly efficient at lowering apnea. There were noticeably fewer tachycardia episodes when caffeine was consumed.
Investigating the role of pharmacogenomics in personalizing medication therapy for children: a pilot study
Authors: Sahu Prerana , Patel Ritesh
Published: February 2025

An antimetabolite that is frequently given for the treatment of both adult and pediatric malignancies is methotrexate (MTX). Because of MTX-related toxicity and pharmacokinetic unpredictability, HDMTX treatment is challenging. Methotrexate disrupts the metabolism of folate by blocking the methylenetetrahydrofolate enzyme (MTHFR). MTHFR polymorphism may affect how well a patient tolerates MTX. Therefore, the study intends to connect the clinical outcome of pediatric ALL patients receiving HDMTX infusions with the serum methotrexate level and MTHFR polymorphism. Between February 2023 and May 2024, a prospective study was conducted at CMC Hospital in Vellore. Acute Lymphoblastic Leukemia (ALL) relapses in children who were younger than 18 years old at enrollment and who are on high doses. Serum methotrexate levels 48 hours following the initiation of HDMTX infusion may be associated with severe methotrexate toxicity. While most patients with the A1298 C homozygous mutant (CC) exhibited increased liver enzymes, we observed that patients with the C667 T variation (CT) had delayed methotrexate elimination. MTHFR genotyping and serum methotrexate drug level prediction are crucial for preventing toxicities in individuals receiving high doses of methotrexate infusion.
Evaluating the safety and efficacy of antenatal corticosteroids in preterm labor: a randomized controlled trial
Authors: Bhoyar Naina , Nirmal Chandu Himanshu
Published: February 2025

Pre-birth corticosteroids (ACS) have been displayed to bring down mortality among early preterm youngsters in low-pay conditions, as per a WHO movement. I primer is at present the best controlled fundamental on ACS security and practicality. One of the most vital pre-birth drugs accessible to improve neonatal results is the utilization of corticosteroids before a commonplace preterm birth. For pregnant women between 24 0/7 weeks and 33 6/7 weeks of bring forth who are at risk for an extemporaneous work in something like 7 days, consolidating those with burst films and various difficulties, a single estimation of corticosteroids is proposed. Regardless of what the number of hatchlings or the condition of layer burst, it could in like manner be contemplated for pregnant women starting at 23 0/7 weeks of agonizing who are at risk for frightening work in the range of 7 days, dependent upon the family's decision concerning reclamation. Here, we review pieces of information acquired from the Action I primer that can be used with an impact helping ACS execution strategy. Significant components included (I) deciding gestational age by ultrasound, (ii) having qualified obstetricians utilize proper determination measures to recognize ladies in danger of preterm birth with the goal that ACS can be regulated, and (iii) offering a fundamental bundle of care to untimely babies in workplaces. This approach effectively diminished baby mortality from ACS utilization by 16% and distinguished a vital number of ladies who in the long run fell pregnant impulsively. To totally scale and weight the benefits of ACS in saving the presences of preterm children, policymakers, program bosses, and experts are asked to ponder this execution plan.
Investigating the role of pharmacogenomics in optimizing medication therapy for pregnant women: a pilot study
Authors: Pratap Dhimar Chandra , Vaishnaw Aayush
Published: February 2025

Each medication that is ordinarily used during pregnancy needs to go through an escalated pharmacokinetic examination. It is trying for a clinician to close whether a prescription's benefits offset its perils when it hasn't been evaluated. Basic thought should be given to getting taught consent, recording patient characteristics, recording drug piece and range, assessing plasma drug levels, and conveying the experience as a case report when clinicians decide to regulate medications that needy individual been completely focused on in pregnancy. Clinicians can augment treatment ampleness by preventing underdosing and limiting overabundance with the associated opposing effects by including improved dosing rules for pregnant patients. Most importantly, specialists could underwrite better medications for the best outcomes and success for both the mother and the undeveloped organism. The most often used intravenous enemy of contamination during pregnancy is cefazolin, which is cleared even more quickly due to extended renal excretion.[10] to stay aware of plasma obsessions above MIC during operation, a higher starting piece and more progressive association are required due to cefazolin's extended volume of movement during pregnancy and its accelerated opportunity.
Assessing the impact of medication therapy management on health outcomes in underserved populations
Authors: Bharti Sao Rupali , Chandrakar Kunal
Published: February 2025

The medication therapy management service in collaboration with psychiatrist was initiated in order to enhance pharmacotherapy and the patient care process. The proactive role of the pharmacist in initiating and providing Patient medication review, Pharmaceutical care plan, Evidence based drug Information and intervention services under MTM services resulted in optimal clinical and economic outcomes for patients with depression, BPAD, ADS, and schizophrenia. Significant improvement in the clinical condition, medication adherence, quality of life and patient satisfaction was observed in test group patients compared to the control group. The pharmacist - psychiatrist collaborative approach helped in early detection and resolution of DRPs, provision of patient education and clinical care services that further resulted in improved clinical and humanistic outcomes besides reduction in economic burden. Patients with psychiatric illness are often has associated with drug related problems. Due to the rapid rise in psychotropic drugs and the increasing prevalence of concurrent medical conditions, pharmaceutical regimens are more complex and more likely to cause drug interactions, side effects, poor adherence, and higher costs. Pharmacists in multidisciplinary psychiatry team as educators, consultants, researchers, and Medication Therapy Management (MTM) services providers for nearly 40 years. To assess the impact of pharmacist-psychiatrist initiated medication therapy management services. The pharmacist - psychiatrist collaborative approach helped in early detection and resolution of DRPs, provision of patient education and clinical care services that further resulted in improved clinical and humanistic outcomes besides reduction in economic burden.
Antimicrobial stewardship in community pharmacies: a mixed-methods study
Authors: Sharma Saurabh , Kumar Sahu Mahendra
Published: February 2025

Although international recommendations support the crucial role that pharmacists play in antimicrobial stewardship (AMS) programs, the degree to which pharmacists participate in AMS programs varies by nation. to investigate the roles that pharmacists play in AMS programs in various income levels and to create interventions tailored to the particular context in order to improve the function of clinical pharmacists in AMS in Kerala, India. There is variance in the degree to which pharmacists participate in the program, which is mostly determined by the AMS training they receive and the backing of hospital administration, even if pharmacist-led or driven AMS treatments are improving patient outcomes. Their involvement in the program can be facilitated by a contextually prepared, standardized, and easily accessible AMS training program, pharmacy curricula that are modified to incorporate AMS, and the acknowledgement of pharmacists' role in AMS. This will help to dismantle long-standing hierarchies and professional boundaries. This would be especially helpful in nations where AMS is severely hampered by a lack of doctors with expertise in infectious diseases.
Clinical applications of MRI in assessing musculoskeletal diseases and injuries
Authors: Pratap Dhimar Chandra , Vaishnaw Aayush
Published: February 2025

Magnetic Resonance Imaging (MRI) has become an essential diagnostic tool in clinical settings, especially for assessing musculoskeletal diseases and injuries. With its ability to provide high-resolution, non-invasive images, MRI is crucial in evaluating soft tissues, including muscles, ligaments, tendons, cartilage, and bones. This research explores the role of MRI in diagnosing common musculoskeletal conditions such as osteoarthritis, sports injuries, and degenerative diseases. We review advancements in MRI techniques, including high-field imaging and contrast-enhanced MRI, and how these innovations have improved diagnostic accuracy. Furthermore, the paper discusses the clinical benefits of MRI in guiding treatment plans, monitoring disease progression, and enhancing post-injury rehabilitation. The growing use of MRI in musculoskeletal assessments highlights its importance in personalized healthcare, aiding in more targeted and effective therapies.
The future of precision medicine in personalized cancer treatment
Authors: Bhoyar Naina , Nirmal Chandu Himanshu
Published: February 2025

The field of cancer treatment has witnessed significant advancements with the emergence of precision medicine, which tailors treatment based on individual genetic, environmental, and lifestyle factors. This research explores the future of precision medicine in the context of personalized cancer treatment, focusing on the application of advanced technologies such as genomic sequencing, biomarker discovery, and targeted therapies. The integration of artificial intelligence (AI) and machine learning (ML) in precision oncology is revolutionizing the way we diagnose, predict, and treat cancer. By identifying specific genetic mutations and molecular characteristics unique to each patient, personalized cancer treatments can improve efficacy, reduce side effects, and increase survival rates. This paper delves into the challenges and potential of precision medicine in oncology, highlighting future directions and the role of interdisciplinary collaboration in advancing personalized cancer treatment.
Exploring the relationship between mental health disorders and medical compliance in patients with chronic diseases
Authors: Sharma Poorti , Chandrakar Kunal
Published: February 2025

The association between mental health conditions and chronic disease patients' adherence to their treatment plans is investigated in this study. Non-adherence to recommended medical treatments can worsen the progression of chronic conditions, which frequently call for long-term treatment plans. It is well known that mental health conditions such as stress, anxiety, and depression have a detrimental effect on patients' compliance with treatment plans and medical advice. The study looks at how patients' willingness and capacity to adhere to medical advice are influenced by things like the intensity of their symptoms, their mental health, and the support networks they have access to. To enhance medical compliance and general health outcomes in the management of chronic diseases, the study intends to draw attention to the necessity of integrated care approaches that address both mental and physical health through an analysis of patient interviews, clinical records, and treatment outcomes.
Analyzing the impact of aging populations on healthcare system sustainability
Authors: Shrivastava Pranjul , Syed Sabir Ali Syed Sajid Ali
Published: February 2025

An international phenomenon, the aging population presents serious problems for healthcare systems. Increased demand for healthcare services, long-term care, and chronic disease management results from the growing proportion of elderly people brought on by rising life expectancy and falling birth rates. The workforce, financial resources, and infrastructure of the healthcare industry are all severely strained by this demographic change. With a focus on important topics like healthcare costs, labor shortages, and the requirement for policy changes, this study attempts to examine how aging populations affect the sustainability of healthcare systems. The study highlights the opportunities and problems brought about by an aging population by reviewing case studies and trends from around the world. The results underscore the significance of creative approaches, including integrated care models, digital health technologies, and policy changes, in guaranteeing the viability of healthcare systems amidst demographic shifts.
Biomechanical impacts of wearable and implantable technologies in post-surgical rehabilitation
Authors: Agrawal Ashish , Chandrakar Kunal
Published: February 2025

A revolutionary development in healthcare is the incorporation of wearable and implantable technologies into biomechanics and surgical practice. A growing number of implantable devices, including smart implants and orthopedic prosthetics, are built with sensors that allow for real-time physiological response monitoring, facilitating individualized care and recovery. Wearable technology, such as motion sensors, smart braces, and exoskeletons, also makes it possible to continuously track biomechanical functions, allowing for accurate movement analysis and the best possible recovery after surgery. These technologies work in concert to improve surgical accuracy, post-operative care, and biomechanical performance understanding, all of which lead to better long-term health outcomes and more effective rehabilitation. These systems have enormous potential to transform individualized healthcare and rehabilitation, notwithstanding obstacles concerning integration, data privacy, cost, and regulation. To bridge the gap between surgical procedures and biomechanical function and ultimately improve patient care and recovery, this abstract emphasizes the crucial intersection of wearable and implantable technology.
Genetic factors contributing to hereditary cardiovascular disorders
Authors: Anand Das Vaishnav Venu , Patel Ritesh
Published: February 2025

Hereditary cardiovascular disorders (HCDs) represent a group of conditions with a significant genetic component, contributing to the development of various heart-related diseases. These disorders are influenced by mutations in specific genes that affect cardiac structure, function, and susceptibility to cardiovascular events. Hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), congenital heart defects, and arrhythmogenic right ventricular cardiomyopathy (ARVC) are some of the prominent HCDs linked to genetic factors. Recent advancements in genomic technologies, such as whole-exome sequencing (WES) and next-generation sequencing (NGS), have facilitated the identification of pathogenic variants and their role in disease pathology. These technologies have not only improved the accuracy of genetic diagnosis but have also enabled the development of precision medicine strategies tailored to individual genetic profiles. Additionally, gene editing tools, such as CRISPR/Cas9, are being explored for potential therapeutic applications, offering hope for correcting specific genetic mutations responsible for HCDs. This study reviews the current understanding of genetic factors contributing to HCDs, explores novel diagnostic and therapeutic approaches, and discusses the challenges associated with translating genetic findings into clinical practice.
Analyzing medical images to detect adverse drug reactions and toxicity
Authors: Dewangan Tripti , Vaishnaw Aayush
Published: February 2025

It is believed that sentiment analysis is the pinnacle of natural language processing. It can be difficult to analyze and comprehend customer reviews and comments. These days, social media sites like Facebook and Twitter allow users to share their thoughts about a product or movie. Online health community platforms like Daily Strength, Me Help, Patients Like Me, and others also offer health-related conversations. Serious negative effects on human bodies brought on by careless medication use without a prescription are known as adverse drug reactions, or ADRs. In the field of pharmacovigilance, the difficult research problem of automatically detecting adverse drug reactions (ADRs) from social media information has drawn a lot of attention. ADR can benefit from the vast amount of data discussion on social media. Therefore, to address the casual vocabulary and misspellings prevalent in social media, effective machine learning approaches are required. Creating deep learning models to identify and enhance ADR performance is the aim of this study. Numerous approaches and algorithms have been put forth to identify adverse medication reactions. To detect ADR, this research study suggests a more accurate and efficient framework called the "Adverse Drug Effect Aware Recommendation System." This study focuses on reviews of a specific drug reaction that were gathered from Twitter.
Analyzing the risk of cyberattacks on pharmacy information systems
Authors: Agrawal Ashish , Chandrakar Kunal
Published: February 2025

As the world moves closer to a cashless and paperless economy, digitization is essential for any firm to succeed. Although initiatives to encourage digitization have been started, cyber risk was overlooked, and the danger of cyberattacks has been rising and is far more than the perceived risk of cyber. Globally, there has been a startling rise in cyberattacks of all kinds, which have in certain cases caused some businesses to become unstable and taken days or months to recover. In addition to the other operational problems, the recovery period resulted in cost and market share loss. This study aimed to determine the factors that influence an individual's readiness to manage cyber risks by examining the role of respondents' online behavior, awareness of cyber risks, experience with cyber risks, and attitude toward cyber risks in lowering the incidence of cyber risks. 385 respondents were given a structured questionnaire by the researcher, and the information gathered was coded and revised for additional analysis. The data was subjected to univariate, bivariate, and multivariate analysis, and the researcher employed regression, t-test, and Anuva to highlight the study's framework. The findings show that an individual's online behavior and awareness of cyber hazards contribute to their readiness to manage those risks. An individual will be able to improve their readiness to manage cyber hazards with the help of the findings
Pharmacy informatics and health information technology a systematic review
Authors: Pandey Rashmi , Nirmal Chandu Himanshu
Published: February 2025

In many developing nations, e-government has become a focal point of governance initiatives. e-Government is thought to be a way to cut expenses, enhance services, save time, boost efficacy, and improve efficiency. The first significant move towards e-governance was the creation of the National Informatics Centre (NIC) in 1977 after the Government of India established the Authority of Electronics in 1970. Information and communication technology has made its way into Indian administration and is already demonstrating its efficacy. In the fields of management and administration, e-governance adaption meets numerous obstacles and difficulties. This study focuses on investigating the elements that influence e-governance's success or failure in relation to the Food and Drugs Control Administration's (FDCA) ten years of e-governance implementation. To expand the uses of eGovernment, it has investigated the potential of geospatial technology and created a spatial decision support system. The Gujarati FDCA's e-governance system is called "eXtended Licensing, Laboratory & Legal Node (XLN)." Since 2007, it has been in operation.
Pharmacists-led interventions to improve medication adherence in global health settings
Authors: Ranjan Dash Smruti , Kumar Sahu Mahendra
Published: February 2025

The sword with two sides, Although medicine has the power to cure diseases, it also has the unspoken potential to damage patients if not used properly. Every healthcare system should prioritize ensuring that patients receive the appropriate medication for their clinical condition at the appropriate time, via the appropriate route, and in the appropriate dosages. Polypharmacy can be helpful because various morbidities are so common, but it can also have unintended harmful effects. In order to forecast the course of treatment, the co-morbidity-polypharmacy score correlates the patient's physiological age rather than their chronological age. Any departure from the medication's anticipated positive effect may be seen as a drug-related issue. In this study, the cost-benefit analysis of clinical pharmacy services and the effects of clinical pharmacist interventions on drug-related issues in polypharmacy prescriptions were examined. Finding and addressing drug-related issues, determining the level of health care providers' acceptance of clinical pharmacist interventions, analyzing the cost-benefit of clinical pharmacy services, and creating and recommending a clinical pharmacists intervention form to standardize and record drug-related issues were the specific goals.
Naturally multiplying the effect of vitamin D in white mushrooms and studying its effect on intestinal microbiota and individual health
Authors: Kareem Rahi Al-Magsoosi Suhad , Almuharib Omar , Hussien S.A. , Anees H. Essa
Published: February 2025

Mushrooms naturally contain vitamin D2, and exposure to UV light can enhance the amounts of vitamin D2 in mushrooms. It is crucial to acknowledge that vitamin D2 is less physiologically potent than vitamin D3 and may not offer the same advantages as vitamin D3 pills or foods containing vitamin D3. In addition, ultraviolet (UV) radiation can also lead to the deterioration of other advantageous chemicals found in mushrooms. Thus, we advise avoiding subjecting mushrooms to ultraviolet (UV) radiation for the purpose of obtaining vitamin D3 supplements. Approach The procedure entails choosing freshly harvested mushrooms from the market and quantifying their vitamin D concentration in 122-gram increments. Remove the caps and halve the mushrooms lengthwise. Once the mushrooms have been divided lengthwise, position them with the gills facing upwards on metal trays. In this orientation, the nostrils are directed upwards. Retrieve the trays and enclose the mushroom pieces in wrapping to prevent moisture accumulation. Solar exposure during the hours of 10 a.m. and 6 p.m. might result in harm. On the second day, the trays weighing 122 grammes had a vitamin D concentration. To increase the concentration, the trays were exposed to sunlight again, this time without being covered. Both males and females were seen to have an increase in vitamin D levels as a result of consuming genetically engineered mushrooms. Prior to meal consumption, the mean concentration of vitamin D3 in males was 13.4 mg/100 ml. However, after ingesting the modified food, it rose by 32 mg/100 ml. This implies that diet has a crucial impact on substantially increasing the concentration of vitamin D in the body. The initial concentration of vitamin D in women was 12.2 mg/100 ml. However, after consuming the modified diet for an entire month, the concentration climbed to 38.6 mg/100 ml. This demonstrates that the modified diet had a substantial impact on boosting the concentration of vitamin D in both genders. an edible resource. The study investigated the impact of vitamin D intake on the bacteria count in adult individuals of both genders. In men, the overall microbial count reduced dramatically to 10,000 cells/ml of culture media following ingestion, in contrast to the initial count of 13,233 cells/ml. After intake, the overall microbial count in women reduced to 12,000 cells/mL, as opposed to the initial level of 20,000 cells/ml.
Green Synthesis of Copper Nanoparticles Using Boerhaavia diffusa: Evaluation of Cytotoxic and Anti-Diabetic Activities
Authors: Vennila Mahendran Kayal , Rajan KV Ranjeth , Priyadarshini Priyadarshini , R. Ramesh.
Published: February 2025

Background: Traditional nanoparticle synthesis methods often involve toxic chemicals, posing risks to the environment and human health. Green synthesis using plant extracts offers a sustainable and eco-friendly alternative. Boerhaavia diffusa, a medicinal herb, is rich in bioactive compounds and has potential for producing biocompatible nanoparticles with therapeutic applications.
Aim: To synthesize copper nanoparticles (CuNPs) using Boerhaavia diffusa extract and evaluate their cytotoxic and anti-diabetic activities.
Materials and Methods: Boerhaavia diffusa leaves were processed to obtain an extract used as a reducing and stabilizing agent for synthesizing CuNPs. The cytotoxicity of the nanoparticles was tested using brine shrimp assays at varying concentrations, while their anti-diabetic activity was assessed through α-amylase inhibition and DPPH assays. Statistical analysis was performed using the Shapiro-Wilk test for data normality, the Kruskal-Wallis test for group comparisons, and Spearman’s rank correlation to evaluate relationships between concentration and observed effects.
Results: CuNP synthesis was confirmed by a color transition and UV-Vis spectroscopy. Cytotoxicity assays revealed survival rates of 70–100%, indicating low toxicity. Anti-diabetic assays demonstrated effective α-amylase inhibition and free radical scavenging. Statistical analysis confirmed significant dose-dependent cytotoxicity and wavelength-dependent absorbance properties.
Conclusion: Boerhaavia diffusa-mediated CuNPs are biocompatible and exhibit promising therapeutic potential, particularly for anti-diabetic applications, highlighting the feasibility of green synthesis for nanomedicine development.