bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of Audio Visual (AV) Aids on improving creative writing skills: A Cross-sectional study conducted in District Peshawar, Pakistan.
Authors: Farooq Akbar  , Sobia Haris  , Muhammad Haris  , Farah Deeba  , Muhammad Jehangir Khan  , Imran Zaman Khan
Published: May 2022

Objectives: To investigate the impact of audio visual (AV) aids on improving creative writing skills and to assess the effectiveness of AV aids in improving students learning outcomes. Study Design: Cross Sectional Quantitative Study. Setting: Hira Secondary School, Peshawar. Period: Sep 2020. Material & Methods: We studied individuals and phenomenon in their natural settings hence, we chose quantitative approaches (Creswell, 2005). Then a sample size of 30 students was taken from the population that was 8th Grade students and was 20% of the target population Sample was collected through simple random sampling technique. The data was collected by distributing questionnaire among the study population who were shown some AV aids in order to improve their writing skills like accuracy, grammar and spelling skills etc. Results: About 38% of the study participants strongly agreed that the AV aids play a prominent role in developing writing skills in students and only 10% disagreed with the statement. Around 52% of the participants strongly agreed with the fact that visual representation of any material clicks the whole context of that material in one single word whereas none of the students disagreed to this fact. Conclusion: We concluded that despite being used to some extent by several teachers, using AV aids in improving writing skills still does not have enough attention as it would deserve, especially considering its benefits it may bring to developing writing skills.
Comparison of 2nd and 3rd wave of SARS-C0V-2 on gender and age basis.
Authors: Ali Aoun  , Noor ul Ain  , Abdul Rehman  , Rashid Sajjal
Published: May 2022

SARS-COV-2 is a deadly virus which emerged in China in late 2019. In this article, the difference in European variant (2nd wave) and UK variant (3rd wave) of COVID-19 in Pakistan was investigated. Polymerase chain reaction (PCR) technique was applied to evaluate the difference in gene sequence of both the variants. The UK variant (3rd wave) was more terrible due to its resistance and genomic mutation. When performed PCR in both the waves, there was nucleocapsid protein (N gene) in UK variant while envelop protein (E) was more prominent in European variant after ORF 1ab in both the strains. People of all age groups were tested and was reported that aged individuals were at more risk of infection as compared to young ones. Similarly females were having more immunity in defence against COVID-19 infection as compared to males that increased more risk of infection to them.
Screening of Blackgram Genotypes for Sulphur Utilization Potential in VerticUstropept
Authors:   Department of Soil Science and Agricultural Chemistry, Tamil Nadu Agricultural University, Coimbatore, Tamil Nadu, India- 641 003, R K Kaleeswari ,   Department of Soil Science and Agricultural Chemistry, Tamil Nadu Agricultural University, Coimbatore, Tamil Nadu, India- 641 003
Published: May 2022

A microplot study was conducted on a medium black soil to screen improved sulphur (S) utilizers among blackgram genotypes. For this experiment, four different S sources including Gypsum, SSP, FeSO4, and ZnSO4, were applied at four levels (S @ 0, 20, 30, and 40 kg ha-1). With the application of high levels of sulphur (40 kg S ha-1), growthand yield parameters (plant height, root length and the number of pods per plant) of black gram increased significantly. Sulphur application in the form of SSP enhanced root length and number of pods per plant. Application of sulphur as FeSO4 recorded maximum consumption by plants (3.17 kg ha-1) followed by ZnSO4 (2.88kg ha-1). Blackgram genotypes VBN 11, CO 6, and VBN 8 were categorized as efficient S utilizers, while CO 7 and MDU 1 were considered inefficient S utilizers
Teologia como Linguagem latino-americana de fé
Authors: Cunha Rogério Ignácio de Almeida
Published: May 2022

Partindo da «Posição da Igreja na atual transformação da América Latina à Luz do Concilio» (II reunião geral do CELAM, Medellín, em 1968), formou-se dentro e fora deste continente uma reflexão que ora se revela uma ‘contralinguagem’, ora se articula como uma nascente linguagem científica. Sua raiz não é uma pesquisa universitária, embora milhares de cientistas sejam perseguidos e prejudicados por causa dela. Sua expressão primária não é a bibliografia especializada — dentro de várias ciências humanas — que já atinge amplidão incontrolável...
Escatologia e Teologia da ação
Authors: Higuet Etienne
Published: May 2022

De alguns anos para cá, a Escatologia reencontrou na Teologia Sistemática o lugar central que nunca deveria ter perdido, dada sua importância tanto no Antigo como no Novo Testamento. A grande geração de teólogos protestantes entre as duas guerras tomou, neste particular, uma ampla dianteira sobre a teologia católica. Entre estes, Paul Tillich, que exerceu sua atividade teológica durante os anos vinte, na Alemanha, e, a partir de 1933, até sua morte em 1965, nos Estados Unidos, foi consciente desde o início da importância capital do problema do porvir na teologia...
Casamento Natural, Casamento-Sacramento e Religiosidade Popular
Authors: Groetelaars Martien
Published: May 2022

No presente artigo queremos refletir sobre toda a problemática pastoral em torno do casamento...
La docencia y sus procesos en instituciones de educación media superior
Authors: López Ramírez Evangelina
Published: May 2022

Esta obra analiza el contexto de la educación media superior en México, concentrándose en los procesos más relevantes que caracterizan a la práctica docente (tales como participación en equipos de trabajo, planeación didáctica, instrumentación didáctica y evaluación de los estudiantes); específicamente, en los siguientes subsistemas: Colegio de Bachilleres (COBACH), Colegio de Estudios Científicos y Tecnológicos (CECYTE) y Dirección General de Educación Tecnológica Industrial (DGETI).
Analysis and investigation on the core competitiveness of textile and underwear industry in the mainland and Taiwan of China and Myanmar under the global value chain
Authors: Wu Haichao , Luo Lan , Zeng Yingshan , Wang Rudan , Zhang Yue , Chu Chien Chi
Published: May 2022

All the way in the "area", "comprehensive economic partnership agreement" (RCEP), Association of Southeast Asian Nations (ASEAN) free trade area, the main economic corridor construction under the background of success, the mainland and Taiwan of China and southeast Asia has established the important relations of cooperation, industries are beginning to consider labor costs, raw materials, using the regional to invest policy and market comparative advantage. This paper starts from the investigation of Topline's core competitiveness in China and Myanmar, and focuses on the analysis of lingerie industry in China and Myanmar, and the analysis of women's underwear industry from the perspective of global value chain (GVC). Through the data analysis of the questionnaire survey, this paper summarizes the problems existing in the current situation of the industry, uses the intermediary analysis to analyze the correlation between the two variables, reveals the role of the core competitiveness of enterprises, and uses the GVC theory to analyze the problems existing in the industry of enterprises and their causes. According to relevant theories, the optimization path of enterprise value chain is put forward.
Development of an electronic measuring device for body weight and nutritional status for children under two years old
Authors: Nasution Naimah , Widyawati Melyana Nurul , Ramlan Djamaluddin
Published: May 2022

Background: Measurement of body weight and nutritional status in children under two years are still used manuals. Besides that, there is no tool to measure nutritional status, so it is necessary to develop a tool to make it easier.Purpose: The study aims to develop and test a measuring device for weight and nutritional status in children under two years.Methods: This study is Research and Development (R&D). It consisted of 5 stages, stage I (literature study), stage II (product development), stage III (expert validity and phase I trials), stage IV (product revision and final product), and stage V (phase II trials).Result: The electronic measuring device for weight and nutritional status has been created. The result is that the tool effectively determines the weight and nutritional status. The average value of tool testing is below 5%, which means the calibration value of the tool's sensitivity is valid in determining body weight. In addition, it can also determine nutritional status with a p=0,65, which means that there is no difference between measuring nutritional status using the tool and manually.Conclusion: The electronic measuring device effectively determines the weight and nutritional status.
PERBEDAAN HASIL BELAJAR PESERTA DIDIK MENGGUNAKAN MODEL PEMBELAJARAN DISCOVERY LEARNING DAN MODEL PEMBELAJARAN STUDENT FACILITATOR AND EXPLAINING
Authors: Thelessy Reynaldo Decaprio , Palinussa Anderson Leonardo , Gaspersz Magy
Published: May 2022

Penelitian ini bertujuan untuk mengetahui ada tidaknya perbedaan hasil belajar peserta didik kelas VII SMP Negeri 1 Leksula yang diajarkan dengan model pembelajaran Discovery Learning dan model pembelajaran Student Facilitator and Explaining pada materi Persamaan dan Pertidaksamaan Linear Satu Variabel. Tipe penelitian yang digunakan adalah penelitian eksperimen (Eksperimental Research) dengan desain penelitian Post Test Only Control Group Design. Populasi dalam penelitian ini adalah seluruh peserta didik kelas VII SMP Negeri 1 Leksula. Sampel dalam penelitian ini adalah 25 peserta didik di kelas VII/2 dan VII/3. Kelas VII/2 sebagai kelas eksperimen 1 dan kelas VII/3 sebagai kelas eksperimen 2. Analisis yang digunakan adalah analisis statistik uji-t dan hasil penelitian menunjukan ada perbedaan hasil belajar peserta didik kelas eksperimen 1 dengan model pembelajaran Discovery Learning dan kelas eksperimen 2 dengan model pembelajaran Student facilitator and Explaining. Hal ini dibuktikan dengan hasil perhitungan yang diperoleh yakni, nilai Sig. (2-tailed) lebih kecil dari nilai  α=0,05 yakni 0,000. Berdasarkan hasil penelitian maka dapat disarankan bagi para pendidik untuk mendampingi dan memfasilitasi pelajar dengan metode pembelajaran kooperatif untuk meningkatkan dapat hasil belajar. Pendidik dapat menerapkan metode pembelajaran Discovery Learning dengan menimbulkan rasa ingin tahu serta mengarahkan peserta didik untuk berusaha memahami konsep melalui proses penemuan informasi yang dilakukan oleh peserta didik sendiri
IDENTIFIKASI JENIS DAN KELIMPAHAN MOLUSKA YANG DIMANFAATKAN SEBAGAI BAHAN PANGAN PADA EKOSISTEM HUTAN MANGROVE, MERAUKE
Authors: Merly Sendy Lely , Mote Norce , Basik Bernadetha Basik
Published: May 2022

Mollusc as one of protein sources beside fish and shrimp in contribute to fulfill whether consumption and nutrition of community in coastal area on Merauke regency. This research conducted at mangrove forest ecosystem in Payum beach start on February-April 2020. Moreover, mollusc shell also functioned as decoration, accessories, and powder to sirih pinang activity namely “kahos”, whilst mollusk meat being cooked. The aims of this research were to identified and analyzed the spesies composition and abundance of consumed mollucs by a local community. The research methods consist of interview and purposive sampling method with 10x10 m plots, also followed by three times repetition in three stations. The result shows there are 9 species of consumed mollucs as a food resource such as Cassidula angulifera, Ellobium aurisjudae, Telescopium telescopium, Terebralia palustris, Terebralia semistriata, Cerithidea anticipata, Nerita lineata, Stramonita gradata and Onchidium daemelii. Overall, the highest composition and relative abundance of mollusc at Station I, II and III belongs to Cerithidea anticipata with total approximately 4.609 ind and relative abundance 46.77%, otherwise Ellobium aurisjudae with total 18 ind and relative abundance 0.18% became the lowest.

 

ABSTRAK

Moluska sebagai salah satu sumber protein selain ikan dan udang turut menunjang pemenuhan kebutuhan baik konsumsi maupun nutrisi bagi masyarakat pesisir di Kabupaten Merauke. Penelitian ini dilaksanakan pada ekosistem hutan mangrove pantai payum dari bulan Februari-April 2020. Selain memanfaatkan cangkangnya sebagai hiasan, aksesoris, dan kapur untuk aktivitas sirih pinang (kahos), daging moluska juga diolah menjadi makanan. Penelitian ini bertujuan untuk mengidentifikasi dan menganalisis komposisi jenis dan kelimpahan moluska yang dikonsumsi oleh masyarakat lokal. Metode yang digunakan yakni wawancara dan purposive sampling method dengan penggunaan plot 10 x 10 m dengan pengulangan 3 kali pada setiap 3 stasiun pengamatan. Hasilnya terdapat 9 jenis moluska yang dimanfaatkan sebagai sumber makanan yakni Cassidula angulifera, Ellobium aurisjudae, Telescopium telescopium, Terebralia palustris, Terebralia semistriata, Cerithidea anticipata, Nerita lineata, Stramonita gradata, dan Onchidium daemelii. Komposisi jenis dan Kelimpahan relatif tertinggi pada Stasiun I, II maupun III yaitu Cerithidea anticipata yakni total individu mencapai 4.609 individu dengan KR 46.77% sedangkan yang paling sedikit adalah jenis Ellobium aurisjudae dengan total individu sebanyak 18 ind dan KR 0,18%.

Kata Kunci: Kelimpahan, komposisi, moluska, mangrove, Merauke
Utilization of Instagram by Glamping Legok Kondang Ciwidey as a Promotion Media during the Pandemic
Authors: Diniati Anisa , Salma Aqida Nuril , Lestari Martha Tri , Devi Ni Luh Putu Febriyanti Suntari , Tasliman Cassey Adela
Published: May 2022

This research aims to describe how social media Instagram that tourism industry players, and the tourists use during the pandemic, can be utilized as a promotion tool so that more people will be interested in traveling again, especially in the era of the new normal. This research uses a qualitative approach with descriptive research type and data collection techniques carried out through in-depth interviews with one key informant, non-participant observation, and document study. The results show that in carrying out its promotion, Glamping Ciwidey utilizes some features of social media Instagram and emphasizes certain content to attract the attention of their target audiences. In modifying the audiences’ behavior, they optimize the ability of the influencer that was involved in building brand awareness and the interest of tourists’ attraction and maximizing the features of posting and reposting content from the influencers also visitors through Insta Story and Instagram Feeds. In providing the information such as product knowledge and persuading the audiences to be interested in visiting, they utilize some of Instagram’s features and emphasize the digital content creation, such as activities and the view around there, the implementation of health protocol, infographic, and repost content.

Keywords: Nature Tourism, Promotion Media, Social Media For Tourism Marketing
Culinary Practical Online Class: A Development of Study Method amid COVID-19 Pandemic
Authors: Grasielda Ivana , Yuwono Victor Kurniawan
Published: May 2022

This study aims to develop learning methods in online culinary practice classes using MOOC (Massive Open Online Class). This research is descriptive exploratory with qualitative methods to find out stakeholders' weaknesses, strengths, and expectations for an effective MOOC design in online culinary practice classes. Stakeholders consist of students, permanent lecturers, part-time lecturers, and experts spread across all regencies/cities in East Java and other regions in Indonesia. The study results concluded that the MOOC design was able to meet the expectations of stakeholders, namely that practicum classes could be delivered effectively even though the duration was less than the classes before the new normal era. An effective MOOC means that all components must be planned holistically for both lecturers and students, but lecturers are also obliged to complete the teaching components before learning begins. Starting with determining the theme as a focus, then designing teaching methods supported by giving assignments, assessments, and feedback. This component must have a conducive learning atmosphere, which requires full cooperation and trust between lecturers and students. The overall MOOC plan should be visualized and communicated regularly from the first week of learning.

Keywords:   Online, Blended Learning, Project-Based Learning, Practical, Culinary
A Comparison of The Official Tourism Website Effectiveness of Bali And North Sumatra Province: A Content Analysis Approach
Authors: Akbar M Aulia , Wibowo S. Kunto Adi , Fuady Ikhsan
Published: May 2022

This study discusses the comparison of Bali and North Sumatra Tourism website in terms of website effectiveness. A content analysis method consisting of three dimensions, namely Aesthetics (Destination Visualisation and Web Design), Informative (Uniqueness and Cultural Promotion), and Interactive (E-travel planners and Online Communities), is used to analyze and assess tourism website both on the island of Bali and North Sumatra. The results is there are differences in the use of the Destination Visualisation Factor (AES1) and Web Design (AES2). Meanwhile other dimensions are no difference. This analysis can be used by tourism organizations to use the website better to promote and marketing tourism.

Keywords:   Content Analysis, Effectiveness, Tourism Website, Bali, North Sumatra
Matt Buckner’s Identity Seeking in Green Street Hooligans Movie (2005): A Semiotic Analysis
Authors: Riza Rivaldi Alvien , Amalia Syahara Dina
Published: May 2022

This research was conducted to analyze how the identity seeking of the main character, Matt Buckner, in Green Street Hooligans (2005) movie was portrayed semiotically.  The term identity can be defined as an expression of the inner self, and the role of ourselves in the world to find the meaning of life and as a guide in life to find happiness. The subject of this research was the Green Street Hooligans (2005) movie directed by Lexi Alexander and the object was the representation of the main character’s identity seeking through images of the scene and dialogues found in the movie. The data were collected through watching and analyzing the movie, reading several related articles, taking notes on the important elements, and classifying the data. In analyzing the data, the researchers used a descriptive qualitative approach and adopted the semiotic analysis technique by Charles Sander Peirce (Hoed, 2007). As A Result, the researchers discovered that Matt Buckner's life before being a Hooligan was just like a normal student’s. Second, Matt Buckner’s identity started to transform when he met Pete and join the GSE firm. The last, and the reasons why Matt Buckner joined the Hooligan was that he felt more appreciated and well-known when he became Hooligan, also he was proud to be a Yankee surrounded by the GSE members. Every sign represented in movie have its meaning, and to comprehend those all signs used a semiotic approach. Based on the result of this research, the researchers able to understand the meaning that represented in the Green Street Hooligans movie.
Social Media Utilization for Self-Regulated English Learning during COVID-19 Outbreaks
Authors: Maulina Maulina , Nasrullah Rahmat , Wanci Risman
Published: May 2022

It is quite challenging at this moment for undergraduate students to study from home (SFH) during the COVID-19 outbreaks. Social distancing practices applied during the coronavirus outbreaks to most of the public settings, including at academic activities at university. Fortunately, there have been many platforms of social media provided and accessed easily in this digital era. This current study aimed at investigating and understanding higher education students’ perspectives on social media in learning English independently in the COVID-19 outbreak. Researchers used an online survey as the main research instrument to gather data from 147 potential students to be the respondents to fill out the survey from three universities in the Sulawesi region, Indonesia. The result showed that 81% of respondents used WhatsApp as the medium to study autonomously at home during the pandemic. Besides, YouTube (77.6%), Instagram (57.8%), Facebook (29.3%), and Twitter (24.5%) also became the additional choices. They used those friendly-users and cheap accessed social media platforms to watch and to listen to English videos (79.6%) also to have the written chats in English with friends and teachers (67.3%) as well as to have the audio and video calling in English (36.1%). Further, during the pandemic, respondents improve their speaking skills (37.4%), listening skills (29.3%), reading skills (17%), and writing skills (16.3%) through social media. Even though the world is distracted, university students in this region keep their motivation to learn English from home autonomously.
Archetypes & Self-Realization in Disney’s Cruella (2021) Movie: Jungian Psychoanalysis
Authors: Fatihah Nadyatul , Mustofa Ali
Published: May 2022

The research focused on archetypal elements in the Disney film Cruella. The goal was to see how Estella's personality reflected Jung's archetype theory. Carl Gustav Jung identified the major archetypes, which are the result of shared ancestral experiences that can be found in art, literature, and religion but are not readily evident to the naked eye. Archetypes are inherited, universal patterns of people, actions, or personalities that have an impact on human behaviour. Watching the movie, reading the movie's transcription, selecting quotes, studying cinematographic elements, identifying the data based on the study's theme, and classifying the data to point out the issues of Jung's archetype in the movie were all used to assemble the data. According to the findings, Jung's archetypes were depicted in the film. The results of the research revealed that the main character's speech and actions reflected Jung's archetypes. According to the discussion, Estella's mental growth is obtained from three aspects: her persona, shadow, and self-realization. Self-realization is attained through breaking free from the constraints of the persona, recognizing and accepting the shadow, and balancing the two sides. Despite being difficult and perhaps dangerous, those are critical stages on the way to mental and psychic developmen
A Modern “machine for living”. The Villa Girasole in Marcellise in Italy
Authors: Pagliuca Antonello , Gallo Donato , Trausi Pier Pasquale
Published: May 2022

In the XX century, Italian architects experimented with the use of new European construction vanguards: concrete and steel materials for building frames, new cladding systems, and many other technologies for structures and envelopes. However, while other countries have imposed heavy economic sanctions on Italy, the Italian Government adopted an economic protection protocol to improve protectionist policies of self-production. This situation has led to the optimization of national resources and the creation of experimental models of architecture, often beyond the “limits of physics”. Villa Girasole in Marcellise (Verona, Italy) by Angelo Invernizzi is a current example of this innovation process, which has enhanced knowledge about construction techniques, domotics, and building energy systems. Villa Girasole has been described as a masterpiece of Italian Rationalism and Futurism architecture. In fact, the building can turn on itself with a revolving and circular rails system (as aeronautical engineering systems). With this movement, the building can follow the daily and seasonal orientation of the sun, improving the building’s energy performance. Moreover, the building adopted a futuristic cladding system (Alumàn), many insulating Italian materials (Eraclit), and important building systems like concrete framework (with Vierendeel beams) and steel frames. The construction and typological analysis of this masterpiece represent a necessary condition to improve the knowledge of the contemporary design process. In fact, from the heritage experience, the architects can design new building systems that follow the requirements of environmental sustainability and energy saving, with domotics systems and new building materials.
DNA Cell Cycle Analysis with Propidium Iodide (PI) in Liver Cancer Patients
Authors:   Dubai Medial College, United Arab Emirates, Hussein Mohamed
Published: May 2022

Hepatocellular Carcinoma (HCC) ranks as the fifth most common cancer and, with over 600,000 deaths per annum, it constitutes a major global health problem. The main aetiologies of chronic liver injury are chronic hepatitis C virus (HCV) and hepatitis B virus (HBV) infections, alcohol abuse and, as a result of metabolic syndrome reaching epidemic proportions, an increasing prevalence of non-alcoholic steatohepatitis (NASH). Biomarkers are being developed as alternatives to liver biopsy for predicting liver fibrosis in patients with chronic hepatitis C. The aim of this study was to investigate DNA Cell cycle in HCC, Fibrosis patients and compare with healthy control group. They were classified into three different groups 51 individuals diagnosed Fibrosis patients, 30 Hepatocellular Carcinoma patients and 40 healthy Control individuals with no liver diseases. Tumor Markers including CEA and AFP were estimated using ELISA method, DNA cell cycle was assessed using Flow Cytometry. Results showing sub G1 was increased significantly in both HCC and Fibrosis patients with values 9.55 ± 4.72 and 17.7 ± 5.9; respectively comparing with Healthy control group 5.7 ± 3.36 (p<0.005). On the other hand, G0/G1 was decreased significantly in both HCC and Fibrosis patients with values 62.2 ± 10.02 and 53.4 ± 11.1, respectively while in Healthy control. In addition, AFP and CEA were increased in both HCC and Fibrosis patients comparing with Control. Conclusion based on this study DNA cell cycle could help in assessment of Liver damage especially HCC.
Recent Advancements of Nanotechnology-Based Strategies for Overcoming Tumor Microenvironment Hypoxia
Authors: Wu Jiangchao , Song Jinyuan , Yin Xianghong , Tang Jianghui , Zhang Junlei , Wang Xun , Ji Yongtao , Zhao Yaxing , Chen Dong , Sheng Jianpeng , Bai Xueli , Liang Tingbo
Published: May 2022

Hypoxia is a typical characteristic of most solid malignancies, which has multiple effects on malignant phenotypes and biological behaviors of tumors including epithelial-mesenchymal-transition (EMT), invasion, migration, metastasis, autophagy, stem cell maintenance, pathological angiogenesis, drug resistance, and immunosuppression. Rcentlyumoand reversing the tumor hypoxic environment via nanotechnology has emerged as a novel therapeutic approach for the treatment of malignancies. The main strategies related to nanotechnology to alleviate or ameliorate hypoxic environment are as follows: (1) Bringing external oxygen to tumor hypoxic microenvironment; (2) Generating oxygen based on nanotechnology in situ; (3) Regulating the structure of the tumor microenvironment; (4) Decreasing oxygen consumption in the tumor microenvironment. In this review, we will discuss these nanotechnologies in detail.
A Possible Synergistic Herbal Solution for COVID-19
Authors: Lansky Ephraim Shmaya
Published: May 2022

The COVID-19 pandemic has provided an opportunity for repurposing of drugs, including complex, natural drugs, to meet the global need for safe and effective antiviral medicines which do not promote multidrug resistance nor inflate medical costs. The author herein describes his own repurposing of herbal tinctures, previously prepared for oncology, into a possibly synergistic, anti-COVID 41 “herb” formula of extracts derived from 36 different plants and medicinal mushrooms. A method of multi-sample in vitro testing in green monkey kidney vero cells is proposed for testing the Hypothesis that even in such a large combination, antiviral potency may be preserved, along with therapeutic synergy, smoothness, and complexity. The possibility that the formula’s potency may improve with age is considered, along with a suitable method for testing it. Collaborative research inquiries are welcome.
Transcatheter Tricuspid Valve Replacement: A Feasible Solution to a Real-world Problem
Authors: Nagraj Sanjana , Goldberg Ythan H. , Scotti Andrea , Ho Edwin , Assafin Manaf , Chau Mei , Latib Azeem
Published: May 2022

Background and Objective: As one of the most prevalent valvular pathologies affecting millions globally, moderate-to-severe tricuspid regurgitation (TR) predisposes to increased mortality. Despite the well-established risk of adverse outcomes, an overwhelming majority of TR patients are managed conservatively due to challenges associated with timely diagnosis, clinical course of the disease, competing comorbities that carry prohibitive surgical risk, and poor surgical outcomes. These challenges highlight the importance of transcatheter tricuspid valve replacement (TTVR) which has restructured TR management in promising and innovative ways. Methods: We start with an overview of the pathophysiology of TR considering its implications in management. We then elaborate on the current state of TR management, including its limitations, thereby highlighting the unique role of TTVR. This is followed by a review of perioperative considerations such as careful patient selection, role of multimodality imaging, the various imaging techniques that are available and their contribution towards successful TTVR. We then review the valves that are currently available and under investigation, including the latest data available on device efficacy and safety, and highlight the ongoing clinical trials. Results and Conclusions: TTVR is evolving at an exponential pace and has made its mark in the treatment of severe symptomatic tricuspid regurgitation. The promising results sustained by currently available devices and ongoing investigation of valves under development continue to pave the path for further innovation in transcatheter interventions. However, it is important to acknowledge and appreciate the novelty of this approach, the lack of long-term data on safety, efficacy, morbidity, and mortality, and use the lessons learned from real-world experiences to provide a definitive and reproducible solution for patients with symptomatic TR.
Cardiac Hypertrophy: From Pathophysiological Mechanisms to Heart Failure Development
Authors: Caturano Alfredo , Vetrano Erica , Galiero Raffaele , Salvatore Teresa , Docimo Giovanni , Epifani Raffaella , Alfano Maria , Sardu Celestino , Marfella Raffaele , Rinaldi Luca , Sasso Ferdinando Carlo
Published: May 2022

Cardiac hypertrophy develops in response to increased workload to reduce ventricular wall stress and maintain function and efficiency. Pathological hypertrophy can be adaptive at the beginning. However, if the stimulus persists, it may progress to ventricular chamber dilatation, contractile dysfunction, and heart failure, resulting in poorer outcome and increased social burden. The main pathophysiological mechanisms of pathological hypertrophy are cell death, fibrosis, mitochondrial dysfunction, dysregulation of Ca2+-handling proteins, metabolic changes, fetal gene expression reactivation, impaired protein and mitochondrial quality control, altered sarcomere structure, and inadequate angiogenesis. Diabetic cardiomyopathy is a condition in which cardiac pathological hypertrophy mainly develop due to insulin resistance and subsequent hyperglycaemia, associated with altered fatty acid metabolism, altered calcium homeostasis and inflammation. In this review, we summarize the underlying molecular mechanisms of pathological hypertrophy development and progression, which can be applied in the development of future novel therapeutic strategies in both reversal and prevention.
ВІЗУАЛІЗАЦІЯ НАВЧАЛЬНОГО МАТЕРІАЛУ В ПРОЦЕСІ ПІДГОТОВКИ МАЙБУТНІХ УЧИТЕЛІВ МАТЕМАТИКИ ЗАСОБАМИ СЕРЕДОВИЩА GEOGEBRA
Authors: Дубовик Віталій , Рудницький Сергій
Published: May 2022

Формулювання проблеми. Навчання майбутніх вчителів математики потребує високий рівень візуалізації навчального матеріалу. Інтеграція динамічного середовища GeoGebra у навчальний процес може допомогти покращити навички та знання студентів, а також підвищити рівень викладання для досягнення бажаних цілей навчання.
Матеріали і методи. У ході роботи використовувались наступні методи: теоретичні (аналіз науково-методичної літератури для дослідження стану проблеми застосування засобів візуалізації методами комп’ютерної математики); емпіричні (спостереження та систематизація інструментів GeoGebra на лекційних і практичних заняттях дисциплін «Лінійна алгебра» та «Диференціальна геометрія і топологія»). Показано, як за допомогою GeoGebra можна будувати та досліджувати просторові та плоскі криві; виконувати дії над матрицями.
Результати. Розглянуто особливості використання авторських аплетів та інших розробок GeoGebra під час викладання дисциплін диференціальна геометрія та лінійна алгебра у процесі підготовки майбутніх вчителів математики, зокрема описано можливості застосування даного інструмента для дослідження властивостей просторових кривих і формування практичних вмінь та навичок виконання операцій над матрицями, знаходження обернених матриць. Висвітлено переваги та недоліки використання середовища GeoGebra в освітньому процесі з лінійної алгебри та диференціальної геометрії.
Висновки. В сучасному світі впровадження інформаційних технологій в освітній процес є необхідною компонентою успішного засвоєння навчальних дисциплін з математики. Однією з потужних систем комп’ютерної математики для динамічної візуалізації, розрахунків під час розв’язування задач, обробки даних та науково-дослідницької роботи є середовище GeoGebra. В роботі на прикладі окремих математичних дисциплін показано переваги використання даної системи в освітньому процесі.
ФОРМУВАННЯ У МАЙБУТНІХ УЧИТЕЛІВ МАТЕМАТИКИ НАВИЧОК КОМП’ЮТЕРНОГО МОДЕЛЮВАННЯ У ПРОЦЕСІ РОЗВ’ЯЗУВАННЯ ТЕКСТОВИХ ЗАДАЧ
Authors: Семеніхіна Олена , Друшляк Марина
Published: May 2022

Формулювання проблеми. Розвиток інформаційних технологій і засобів зумовив появу спеціалізованого програмного забезпечення математичного спрямування, в якому є можливим процес математичного моделювання різних класів математичних задач, у т.ч. й текстових. Проте аналіз науково-методичних розвідок засвідчив відсутність напрацьованих методик формування у майбутніх учителів математики навичок комп’ютерного моделювання у процесі розв’язування текстових задач.
Матеріали і методи. Використано теоретичні (теоретичний аналіз, систематизація та узагальнення результатів наукових розвідок для виявлення стану розробленості проблеми, обґрунтування її актуальності в умовах професійної підготовки вчителів математики; моделювання для теоретичного обґрунтування методики формування у майбутніх учителів математики навичок комп’ютерного моделювання у процесі розв’язування текстових задач), емпіричні (педагогічний експеримент для отримання емпіричних результатів упровадження авторської методики) та статистичні (статистичний аналіз (критерій знаків) для підтвердження ефективності розробленої методики формування у майбутніх учителів математики навичок комп’ютерного моделювання у процесі розв’язування текстових задач) методи.
Результати. Розроблена методика формування у майбутніх учителів математики навичок комп’ютерного моделювання у процесі розв’язування текстових передбачає три кроки: 1 крок – викладачем пропонується приклад візуальної моделі текстової задачі, а студенти при цьому мають самостійно скласти алгоритм побудови моделі; 2 крок – викладач пропонує надає готовий алгоритм, за яким студенти самостійно відтворюють візуальну модель; 3 крок – студентам пропонується тип текстової задачі (задача на рух, на спільну роботу, на суміші та сплави тощо), вони підбирають відповідну задачу та самостійно конструюють візуальну модель.
Висновки. Розроблена методика зорієнтована не лише на формування у майбутнього вчителя навичок моделювання інструментами GeoGebra, а й завдяки рольовій грі на третьому етапі своєї реалізації уможливлює усвідомлення як власних помилок у майбутній професійній діяльності, так і типових помилок учнів, які можливі у процесі побудови моделей до текстових задач. Перспективними науковими розвідками вбачається поширення розробленої методики на підготовку вчителів природничих спеціальностей (біології, хімії, географії) та перевірку її ефективності на базі іншого спеціалізованого програмного забезпечення.
ЗАСТОСУВАННЯ ПРОГРАМИ GEOGEBRA ДО ФОРМУВАННЯ ДОСЛІДНИЦЬКИХ УМІНЬ ПІД ЧАС СТВОРЕННЯ ДИНАМІЧНИХ РОЗРОБОК З ГЕОМЕТРІЇ
Authors: Тушев Анатолій , Чупордя Василь
Published: May 2022

Формулювання проблеми. Важливим завданням сучасної освіти є формування у здобувачів умінь самостійно висувати ідеї та знаходити способи їх реалізації, застосовувати знання з різних галузей, самостійно знаходити відсутню інформацію, вміння формулювати гіпотези і встановлювати причинно-наслідкові зв'язки. Пошук ефективних засобів та способів формування та розвитку таких умінь є неодмінною складовою роботи вчителя. Стаття присвячена реалізації формування дослідницьких умінь під якими розуміються вказані уміння. У якості засобу реалізації розглядається програма динамічної математики GeoGebra. Однією з можливостей програми є здатність наявних об’єктів реагувати певним чином на зміни об’єктів даної розробки. У роботі запропоновано використання такої можливості до створення динамічних розробок із залученням здобувачів задля формування та розвитку згаданих умінь.
Матеріали і методи. Аналіз та систематизація науково-педагогічної літератури з використання та впровадження в освітній процес спеціалізованих програмних комплексів, зокрема, програми динамічної математики GeoGebra. Емпіричний аналіз можливостей програми GeoGebra у контексті створення динамічних розробок для навчання геометрії.
Результати. Запропоновано використання можливостей програми GeoGebra показувати/приховувати наявні в області побудови об’єкти до створення динамічних розробок з геометрії та впровадження їх в освітній процес. На прикладі створення розробок з побудови висоти трикутника, побудови ортоцентра трикутника та визначення типу чотирикутника показано впровадження відображення додаткових побудов та відповідних написів в залежності від типу трикутника/чотирикутника.
Висновки. Запропонований підхід із залученням здобувачів освіти до створення динамічних розробок у програмі GeoGebra сприятиме як засвоєнню відповідного матеріалу так і формуванню та розвитку дослідницьких умінь. Зокрема, якісна візуалізація процесу розв’язання поставленої задачі дасть змогу бачити результати впровадження сформульованих гіпотез, знаходити та аналізувати помилки, виправляти їх і одразу перевіряти результат виправлень.
A single nucleotide variant on chromosome 16 residing within KARS distinguishes patients with luminal A breast cancer.
Authors: Mamoor Shahan
Published: May 2022

Molecular subtypes including the most common subtype luminal A drive patient outcomes in human breast cancer but the biological basis for this is not completely understood. We mined published microarray data (5, 6) to discover in an unbiased fashion the most distinguishing genetic and transcriptional features of tumors of each breast cancer molecular subtype. We identified a single nucleotide polymorphism, rs7189895, residing within KARS, as among the most significant genetic differences in the tumors of patients with luminal A breast cancer. In a separate cohort of patients with luminal A subtype breast cancer, we observed transcriptome-wide differential expression of a KARS transcript. Analysis of patient survival data revealed that KARS primary tumor expression was correlated with overall survival in human breast cancer. Sequence variation in the KARS gene may be important in understanding differences in genetic background that favor development of luminal A subtype human breast cancer.
Essays on the Vietnam Stock Market
Authors: Mai Nhat Chi
Published: May 2022

This thesis consists of three substantive studies about the Vietnam stock market. In particular, I study the asymmetric information, corporate governance (CG) practices, and foreign investment of publicly listed companies in Vietnam, presented in Chapters 2, 3, and 4, respectively.In Chapter 2, I investigate the effectiveness of a market surveillance system (MSS) on improving the market quality of the Vietnam stock market, as measured by liquidity and informed trading level. I find that market liquidity decreased after the introduction of the MSS, and that the effect is more pronounced for small firms. Although informed trading, on average, does not change significantly after the MSS, subsample analysis indicates a significant decrease in informed trading among large and liquid firms.In Chapter 3, I investigate the relationship between firms’ CG practices and informed trading. I find a negative relationship between the two variables. Firms with better CG practices have a lower level of informed stock trading. Moreover, a natural experiment on a shock of firms’ CG practices generated by the CG policies shows that the negative relationship between CG practices and informed trading is a causal one, in which a change in the former causes a change in the latter. In another analysis around the implementation of the MSS, I find that the implementation of the surveillance system affects the relationship between the two variables, and this effect is driven by large and liquid firms.In Chapter 4, I investigate whether foreign investors in the Vietnam stock market are informed about firms’ performance. Using the residuals of foreign investor ownership as a measure of the abnormal foreign investor holding, I find that the abnormal foreign investor holding is positively correlated with firm performance in the following one year. I also find a positive correlation between abnormal foreign investor holding and the stock returns in the next three quarters. These findings indicate that foreign investors are informed about the firms up to a one-year period.
Tugas metodolodi penelitian rizki mawarni
Authors: Mawarni Rizki
Published: May 2022

Analisis jurnal PICO adalah penggunaan masing-masing komponen untuk menentukan Populasi, Problem (masalah), Intervensi, Komparasi (perbandingan), dan Luaran (Outcome). Mendeley adalah aplikasi yang memudahkan mengelola database berupa karya ilmiah. Sehingga seseorang tidak akan kesulitan saat menuliskan daftar pustaka. OSF adalah singkatan dari Open Science Framework yang dapat menjadi solusi menerbitkan tulisan dalam waktu yang singkat, memiliki DOI dan langsung terindex ke google scholar.
Nghiên cứu - Trao đổi: Về vai trò của nghiên cứu trong giáo dục Việt Nam thời đại 4.0
Authors: Hoàng Vương Quân
Published: May 2022

Cách mạng 4.0 đã và đang mang đến sự thay đổi lớn trong đời sống của người dân Việt Nam. Sự tiện dụng của Grab, khả năng cập nhật 24/24 của Facebook, hay sự đa dạng về nội dung của YouTube thúc đẩy xã hội tiến tới thời đại mới của khởi nghiệp điện toán (Vuong, 2019). Ở đó, mỗi cá nhân đều có cơ hội để khởi nghiệp thông qua sự kết nối đến khắp mọi nơi trên thế giới của Internet và sức mạnh tính toán nằm gọn trong long bàn tay. Hiện nay, sản xuất video trên YouTube, cho thuê nhà qua AirBnb, hay chạy xe cho Grab tạo ra công việc có khả năng tạo lợi nhuận cho người tham gia thị trường, dù là người lao động, hay tổ chức cung ứng dịch vụ.
PHÂN TÍCH TÁC ĐỘNG CỦA TỶ GIÁ HỐI ĐOÁI VÀ LẠM PHÁT LÊN GIÁ VÀNG TẠI VIỆT NAM
Authors: Mai Nhat Chi
Published: May 2022

Chính phủ, các nhà đầu tư tổ chức và cá nhân đầu tư vào vàng vì những lý do khác nhau. Có thể là nhằm mục đích bảo hiểm rủi ro chống lạm phát hoặc có thể là đầu tư mang tính đầu cơ. Trong thời điểm hiện tại, nền kinh tế của Việt Nam là vô cùng phức tạp; khó khăn đối với chính sách kinh tế vĩ mô, cũng như ảnh hưởng đến quyết định của các nhà đầu tư tìm kiếm lợi nhuận. Từ biến động của giá vàng, các nghiên cứu về mối quan hệ giữa giá vàng, tỷ giá USD/VND và lạm phát sẽ giúp các nhà đầu tư để phòng ngừa rủi ro và phát triển thị trường vàng ở Việt Nam cũng như giúp đưa ra các chính sách phù hợp.
Trend of Antenatal Bookings in a Teaching Hospital in South Western Nigeria
Authors: Oloyede Olufemi A. , Adefuye Peter O. , Akiseku Adeniyi K.
Published: May 2022

Introduction: The age-long practice of late booking is gradually changing towards early pregnancy booking because of the benefits. Implementation of new medical guidelines is however often delayed in developing countries. Aim: The study proposes to observe the trend in antenatal booking in respect of booking gestational age, and the relationship with maternal socio-demographic and obstetric characteristics. Methodology: A retrospective study of antenatal bookings between 2016 and 2020 in Olabisi Onabanjo University Teaching Hospital, Sagamu Ogun State, Nigeria was carried out. Data were collected from pregnant women that had a minimum of 4 clinic attendances and delivered in the hospital. Data analysis was by descriptive statistics and presented in simple frequency tables. Results: Six thousand, eight hundred and ninety-nine pregnancies were booked, with early bookings (< 13 weeks) in 23.9% and late bookings in 64.6% (14-26 weeks) and 11.5% (27-36 weeks). The proportion of early bookings (23.9%) was higher compared with 18.8% reported in 2014 in same centre. Every year, the number of early bookings was initially stable at 20.4%, but rose to 26.7 - 30.8 in the last 2 years of study. Maternal age < 30 years, secondary or tertiary educational level and previous caesarean delivery were the predominant variables among women that booked in early pregnancy. Previous or on-going medical disorders and/or delivery complications were not strongly associated with early booking. Conclusions: The practice of late pregnancy booking is still a major issue, though the proportion of early bookings has continued to increase compared with previous study. Improvement in education, economic empowerment and health education that emphasizes preventive rather than curative role of ANC is advised.
A TLBO-Tuned Neural Processor for Predicting Heating Load in Residential Buildings
Authors: Almutairi Khalid , Algarni Salem , Alqahtani Talal , Moayedi Hossein , Mosavi Amir
Published: May 2022

Recent studies have witnessed the remarkable merits of metaheuristic algorithms in optimization problems. Due to the significance of early analysis of thermal load in energy-efficient buildings, this work is carried out to introduce and compare four novel optimizer techniques of firefly algorithm (FA), optics inspired optimization (OIO), shuffled complex evolution (SCE), and teaching-learning-based optimization (TLBO) for accurate prediction of heating load (HL). The models are applied to a multilayer perceptron (MLP) neural network to surmount its computational shortcomings. The models are fed by a literature-based dataset obtained for residential buildings. The results revealed that all used models are capable of properly analyzing and predicting the HL pattern. A comparison between them, however, showed that the TLBO-MLP with the co-efficients of determination 0.9610 vs. 0.9438, 0.9373, and 0.9556 (respectively for FA-MLP, OIO-MLP, and SCE-MLP) and also root mean square error of 2.1103 vs. 2.5456, 2.7099, and 2.2774 presents the most reliable approximation of the HL. It also surpassed several methods used in previous studies. Thus, the developed TLBO-MLP can a beneficial model for subsequent practical applications.