bluuebunny/crossref_metadata_2025 huggingface dataset:
MUDANÇAS NA PERCEPÇÃO E PERCEPÇÃO DAS MUDANÇAS
Authors: Guerra Gutemberg Armando Diniz
Published: October 2020

A frequência ao Município de Salinópolis desde os finais dos anos 80 do século XX, inicialmente em visitas com hospedagem em casas de familiares até a fixação de moradia em dezembro de 2018, me proporcionou uma mudança de percepção sobre esse ambiente e seus múltiplos aspectos...
Bibliometric Analysis on the Research Trends in the Journal of Korean Society of Beauty and Arts using Text Network Analysis
Authors: Kim Shin-Hee
Published: October 2020

The purpose of this study is to identify the research stream and trend in the field of beauty by using bibliometric analysis based on text network analysis. 792 research papers that had been published in The Korean Society of Beauty and Arts from 2008 to 2019 were collected and network analysis was conducted through text mining, pre-processing, purifying of data. key findings are as follows. First, the quantitative and qualitative aspects of the research have improved since 2016, and methodology focused on the words such as influence, use, effect expression, recognition, change, comparison, performance, and actual state. Second, during the introduction period, researches focused on identifying the effects of certain issues related to beauty for women. Third, research methodologies were diversified during the growth period, and business studies related to the satisfaction of beauty services were increased. Fourth, it was expanded to the researches on service satisfaction and follow-up behavior and researches on psychological aspects in the period of maturity. This study is valuable in that it provides useful information that is required for the new research in the beauty field, along with identifying existing research trends.
Vietnamese Women’s Perception of Semi-permanent Makeup
Authors: Kim Kyeong-Ok , Yoo Wang-Keun
Published: October 2020

This study was conducted to provide basic data needed to analyze and develop Korean semi-permanent makeup training and treatment methods in consideration of Vietnamese women’s needs after investigating their perception of semi-permanent makeup. For this purpose, a survey was conducted from May 10 to August 10, 2019 (90 days) on 294 women living in Hanoi, who have been interested in semi-permanent makeup and the results found the followings: When asked how much they were aware of semi-permanent makeup, ‘little’ was responded. When asked how they got to know it, ‘spa’ was most responded. More than half of the respondents were aware of semi-permanent makeup, and 59.2% believed that it is close to plastic surgery. When asked how safe the makeup treatment is, they mostly had a positive response. In comparison to with tattoos, nearly 66% of the respondents were aware of the differences. When asked if they were informed of semi-permanent makeup training institutions, about 70% said ‘Yes’. In terms of relations among disinfection, hygiene and infection, 75.5% were aware of the risk of infection. It is anticipated that the study results would be available as useful basic data needed to develop Korean semi-permanent makeup programs and give related training in Vietnamese aesthetic industry which has been rapidly growing.
Analysis of Self-stretching, Health Promotion Behavior and Scalp Care Attitude in according to the age of Cosmetologists
Authors: Ju Min-Kyung
Published: October 2020

This study investigated the effects of health promotion behavior after self-stretching on scalp care attitude. For this, a questionnaire survey was performed against cosmetologists in Gwangju and Jeollanam-do, and a total of 191 copies were collected. The collected data were analyzed by frequency analysis, descriptive statistics and one-way ANOVA, and the results found the followings: First, according to analysis of self-stretching, self-stretching behavior, health promotion behavior and scalp management behavior, 46.6% revealed ‘good health condition’. Specifically, ‘self-stretching behavior’ and ‘health promotion behavior’ accounted for 2.60% and 2.88% respectively. In other words, most respondents have been well aware of their scalp conditions and problems and handled them properly. Second, in terms of age, as the respondents were younger, stretching was less important in self-stretching and self-stretching behavior. In health promotion behavior, on the contrary, as they were older, health promotion behavior improved. The above results confirmed that health promotion through daily self-stretching have a positive effect on the scalp. It is anticipated that the development of scalp care-related programs would enhance satisfaction because of healthy scalp care and a healthy lifestyle.
The Effects of Long-term Mask Wearing on Aesthetic Behavior: Focusing on the COVID-19 pandemic
Authors: Kim Min-Jeong , Yu Chae-Mok
Published: October 2020

This study attempted to examine self-skin recognition and aesthetic behavior as well as providing basic data needed to develop strategies in preparation for the post-COVID-19 era in the beauty industry. For this, an online survey was performed among a total of 150 adult men and women aged 20 or older who have worn a mask regularly during the COVID-19 pandemic, and the results of the survey revealed the following: First, mask-wearing intention had a positive influence on mask-wearing experiences. Second, in self-skin recognition, mask-wearing revealed a significant effect on the recognition of causes of skin problems, but no significant influence was found in recognition of skin problem symptoms. Third, mask-wearing had a statistically significant effect on hygienic attitudes, but no significant influence on skin problem-solving attitudes or makeup application attitudes. Fourth, mask-wearing had a statistically significant effect on care-persistence behavior, but no significant influence on skin aesthetic consumption. Fifth, according to the analysis of differences in mask-wearing intention and experiences, self-skin recognition, aesthetic attitude, and aesthetic behavioral intention by gender, a statistically significant difference was found among all items. In terms of post-COVID-19 strategies in the beauty industry, this study suggests a necessity of promoting online education and consultation based on skin knowledge, introducing and improving service providers’ competencies, establishing hygienic environments, and developing new programs, which are difficult to implement at home.
The Effects of Awareness of Certification of National Nail-care Technicians on Applicability at Work and Satisfaction with License Acquisition
Authors: Lee (Sun-Hwa , Yang Chung-Eun
Published: October 2020

This study investigated the effects of the awareness of national nail-care technician certification on its applicability at work, satisfaction with license acquisition and the influence of such job applicability on satisfaction with license acquisition. It is anticipated that the study results would enhance people’s perception on the certification of national nail-care technicians and increase its usefulness at work. For this, a questionnaire survey was conducted among students majoring in cosmetology in Daegu and Gyeongsangbuk-do, who had provided nail-care service at least once and those who earned certification as a national nail-care technician or who had taken the license test before among nail salon workers from July 19 to 25, 2019. For data collection, the questionnaire was distributed to nail salons, private cosmetology academies, colleges and others. The collected data were analyzed through frequency analysis, reliability analysis, correlation analysis, and multiple regression analysis using SPSS 25.0, and the results found the following: First, in sub-factors of the awareness of national nail-care technician certification, ‘value’ and ‘appropriateness of constitution’ had an influence on ‘field applicability’ while ‘cost effectiveness’, ‘necessity’ and ‘utility’ revealed no effect. In addition, while ‘appropriateness of constitution’ and ‘necessity’ affected ‘task applicability’, ‘value’, ‘cost effectiveness’ and ‘utility’ did not show any influence. Second, ‘value’ and ‘appropriateness of constitution’ had an effect on ‘satisfaction with license acquisition’ while no influence was found in ‘cost effectiveness’, ‘necessity’ and ‘utility’. Third, ‘field applicability’ and ‘task applicability’ revealed an influence on ‘satisfaction with license acquisition’.
The Effect of Semi-Permanent Makeup Practitioner's Infection Management Knowledge on the Practice
Authors: Seo Eun-Kyung , Park So-Yeon , Kang Sung-Wook
Published: October 2020

The purposes of this study were to examine the hygienic issues related to the prevention of infection during semi-permanent Makeup procedure s in Korea. The study was conducted from September 2015 to October 2015 with the questionnaire survey about knowledge and practice level regarding the prevention of infection among semi-permanent makeup practitioners in Korea. The survey questions were prepared with managerial guidelines for the prevention of infection. The results showed that the average score of knowledge regarding the prevention of infection was 77.2/100 and that of practice was 3.58/5.00. The results demonstrated that general knowledge on the prevention of infection had positive effects on the practice rate of prevention of infection among semi-permanent makeup practitioners. The authors suggested that both educational programs for the prevention of infection as well as regulation should be established to allow semi-permanent makeup artistry to establish itself as a legal and specialized job field.
The Hair Protection Efficacies of Hair Conditioner Containing Muunsan Extract
Authors: Kim Yu-Ra , Lee Jea-Sook
Published: October 2020

This study attempted to investigate the possibility of using Muunsan extract as a new natural cosmetic ingredient by preparing a hair conditioner containing such an extract, applying it to permed hair, and analyzing its effects with the goal remedying subalhwangrak (yellowish and gray hair losing gloss and smoothness) as defined in oehyeongpyeon (external medicine) of the Donguibogam (Korean medical encyclopedia). According to measurements, ‘V’ was the greatest, followed by ‘C-2’, ‘C-1’, ‘B-2’, ‘A-2’, ‘B-1’, ‘A-1’, and ‘C’ in terms of hair thickness and tensile strength. In other words, ‘C-2 (hair post-treated with a hair conditioner containing Muunsan extract)’ was the best, following only virgin hair in terms of hair thickness and tensile strength. In terms of absorbance, ‘C’ was the highest, followed by ‘A-1’, ‘B-1’, ‘A-2’, ‘B-2’, ‘C-1’, ‘C-2’ and ‘V’. In other words, ‘C-2’ was the lowest, following only virgin hair in terms of the damage index. According to the analysis of cuticle with SEM(Scanning Electron Microscope), scales were most firmly adherent to the scalp and associated hair in ‘C-2’ as exfoliation and unevenness were low. When essential hair components were analyzed by EDS(Energy Dispersive X-ray Spectro mrtry), ‘V’ was the highest with 6.37%, followed by ‘C-2’, ‘C-1’, ‘B-2’, ‘B-1’, ‘A-2’, ‘A-1’ and ‘C’ n terms of sulfur (‘S’) content. The above results proved the hair protection effects of Muunsan extract and confirmed that it would be viable as a new ingredient for hair cosmetics.
Analysis of Volatile Organic Compounds(VOCs) and Cytotoxicity of Hair Dyes
Authors: Kim Jung-Won , Lee Jeong-Hyun
Published: October 2020

In recent years, the beauty industry has undergone dramatic changes in response to demands for safe and sustainable products. In particular, many consumers have become more interested in the safety and origin of the ingredients in their beauty products. This has led to the improvement of laws and regulations concerned with the development of eco-friendly beauty products. Artificial components and chemicals in beauty products can cause direct and indirect harm to the users. This is because most products contain specific volatile ingredients that can be easily ingested by the human body. Until now, there has been little research into the harmfulness of these volatile organic compounds (VOCs) in workplaces, such as beauty salons. In this dissertation, a VOCs analysis and a cytotoxicity evaluation were conducted simultaneously to examine and verify the safety of hair dyes. The VOC evaluation was conducted using the ‘MS 300 55’ method, a vehicle interior air quality testing program. The cytotoxicity evaluation was also performed using the ‘TTT assay’ method. Based on the above results, this study targets the establishment of emission standards of VOCs in aesthetic products and provide basic data needed to develop eco-friendly products and improve work environments for the purposes of safety and sustainability.
Is periodontitis associated with raised blood pressure or hypertension? Evidence from the National Health and Nutrition Examination Survey (NHANES), 2001-2002
Authors: Guan Jing
Published: October 2020

There is incomplete and inconclusive evidence for the correlation between periodontitis and blood pressure, particularly from large national epidemiological studies. The aim of this cross-sectional study was to assess the relationship between periodontitis and blood pressure and hypertension in people in USA, and to analyze confounding factors in both of them.
Penggunaan Metode Tanya Jawab untuk Meningkatkan Keberanian Mengemukakan Pendapat pada Anak Di TKS PGRI Kalianget Barat Sumenep
Authors: Sutrisno Tri
Published: October 2020

The purpose of the research is a benchmark of all research conducted. The objectives in this study are: (1) Want to know the development of children's courage in improving abilities by using the question and answer method. (2) Want to know the impact of using the question and answer method on children's courage in improving their ability to express their opinions. Based on the results of improved learning about communicating / speaking simply in developing the courage of children to express their opinions in Kalianget Barat TKS. Sumenep. In the first cycle, the highest value achieved by children was 80 as many as 10 children, the lowest value was 20 as many as 4 children and the average grade of 6.46 (67%). While the observation collection of question and answer methods West Kalianget TKS Kab. Sumenep in the first cycle as contained in the observation sheet is known that the teacher uses examples and teaching aids (good), the language used by the teacher is clear and simple (good), the teacher checks the child's understanding by asking questions / giving assignments (good), the teacher gives an opportunity ask questions (enough), children answer questions asked by teachers (enough), logical children's answers (enough), children answer other children's questions (enough), respond by teachers (good), and children discuss (good). In the observations of the first cycle has not shown the active attractiveness of children towards the learning given by the teacher. While in the second cycle the results of improved learning about communicating / speaking simply in developing the courage of children to express their opinions Kalianget Barat TKS Kab. Sumenep. In cycle II, it was found that the highest value achieved by children was 160 by 20 children, and the average grade was 7.9 (75%). While the observation collection of question and answer methods West Kalianget TKS Kab. Sumenep in cycle II as contained in the observation sheet is known that the teacher uses examples and teaching aids (good), the language used by the teacher is clear and simple (good), the teacher checks the child's understanding by asking questions / giving assignments (good), the teacher gives an opportunity ask questions (good), children answer questions asked by teachers (good), logical children's answers (enough), children answer other children's questions (good), responded by teachers (good), and children discuss (good). In observation of the second cycle of learning is smooth and produces a level of completeness that exceeds the target.
Upaya Meningkatkan Motorik Halus dan Kreativitas Anak Melalui Teknik Membatik Sederhana
Authors: Roostin Erna
Published: October 2020

AbstrakTujuan dari penelitian ini yaitu untuk mendeskripsikan peningkatan motorik halus dan kreativitas anak kelompok A Kober Al-Hidayah Desa Rancamulya Kecamatan Sumedang Utara Tahun Pelajaran 2018/2019 setelah penerapan tindakan teknik membatik sederhana dalam pembelajaran.Metode pengumpulan data yang digunakan adalah observasi dan penugasan, melalui lembar penilaian dan lembar pengamatan, dengan teknik analisis data kuantitatif dan kualitatif. Setelah melalui kegiatan teknik membatik sederhana terjadi peningkatan motorik halus anak dari mulai kondisi awal yang masih belum berkembang (BB) sebesar 0%, pada siklus I juga masih belum mencapai peningkatan yang diharapkan karena masih belum berkembang (BB) sebesar 0%, akan tetapi pada siklus II terjadi peningkatan yang cukup signifikan yaitu mulai berkembang (MB) sebesar 41,7%, dan pada siklus III peningkatan yang terjadi sudah mencapai target yang ditentukan yaitu berkembang sangat baik (BSB) sebesar 91,7%. Peningkatan kreativitas anak sama halnya dengan motorik halus dimulai dari kondisi awal yang masih belum berkembang (BB) sebesar 0%, dan pada siklus I belum mencapai peningkatan yang diharapkan karena masih belum berkembang (BB) sebesar 0%, akan tetapi pada siklus II terjadi peningkatan yaitu mulai berkembang (MB) sebesar 41,7%, dan pada siklus III terjadi peningkatan dan mencapai target yang ditentukan yaitu berkembang sangat baik (BSB) sebesar 91,7%. Hal ini membuktikan bahwa melalui teknik membatik sederhana dapat meningkatkan motorik halus dan kreativitas anak.
Penerapan Permainan Maze dalam Pembelajaran untuk Pengembangan Kognitif Anak di TK PKK Jalmak Desa Jalmak Kecamatan Pamekasan Kabupaten Pamekasan Jawa Timur
Authors: Wahyuni Sri , Usman Jamiludin
Published: October 2020

Penelitian ini bertujuan mengetahui Penerapan Permainan Maze dalam Pembelajaran untuk Pengembangan Kognitif Anak di TK PKK Jalmak Pamekasan. Jenis penelitian ini yang digunakan adalah Penelitian Kualitatif metode bermain yang dilaksanakan di TK PKK Jalmak Pamekasan. Subjek penelitian ini adalah Kelompok TK-A2 yang berjumlah 20 anak, yang terdiri dari 13 anak laki-laki dan 7 anak perempuan. Objek yang diteliti adalah pengembangan kognitif anak. Teknik pengumpulan data dari penelitian adalah wawancara, observasi, dan dokumentasi.Hasil penelitian menunjukkan bahwa: pertama, penerapan permainan maze dalam pembelajaran untuk pengembangan kognitif anak di TK PKK Jalmak Pamekasan dilakukan dengan cara guru menjelaskan atau mempraktikkan kepada anak-anak. Setelah guru menjelaskan kepada anak lalu anak tersebut melakukan permainan tersebut hingga selesai dengan cara mewarnai jalan mana yang harus dituju. Jika ada yang kurang paham atau mengerti guru mengulangnya lagi penjelasan tentang bagaimana permainan maze. Kedua, faktor pendukung dari penerapan permainan maze dalam pembelajaran untuk pengembangan kognitif anak yaitu guru selalu memberikan motivasi terhadap anak dan sarana bermain yang disediakan untuk merangsang dan mendorong eksplorasi anak. Ketiga, faktor penghambat dari penerapan permainanmaze dalam pembelajaran untuk pengembangan kognitif anak yaitu media penunjang lain berupa permainan edukatif yang belum begitu lengkap, sehingga mengambil gambar di internet dan diprint out sebagai media pembelajaran. Hasil penelitian menyimpulkan bahwa pengembangan kognitif anak di TK PKK Jalmak Pamekasan mulai berkembang secara maksimal dibuktikan dari 20 anak, 2 anak belum berkembang dan 18 anak sudah mulai berkembang.
On the spectral properties and positivity of solutionsof a periodic boundary value problemfor a second-order functional differential equation
Authors: Alves Manuel J. , Labovskiy Sergey M.
Published: October 2020

For a functional-differential operator
Lu = (1/ρ)(-(pu')' + ∫_0^l▒〖u(s)d_s r(x,s)〗)
with symmetry, the completeness and orthogonality of the eigenfunctions is shown. Thepositivity conditions of the Green function of the periodic boundary value problem areobtained.
On the possibility of obtaining the optimal order of accuracy when restoring the impact by the dynamic method
Authors: Vdovin Andrey Yu. , Rubleva Svetlana S.
Published: October 2020

Yu. S. Osipov and A. V. Kryazhimsky proposed a method of dynamic regulationto restore an unknown effect in a controlled model. In the framework of this approach, inthe present work we study the property of another method based on the use of the implicitEuler method for the problem of numerical differentiation. The choice of the parameters ofthe method is indicated, which makes it possible to increase its efficiency, reduce the noiselevel of the approximate solution, and obtain the optimal order of accuracy in the metricL(T); equal to 1/2.
The Description of Family Functioning in Mental Disorder
Authors: Rizqa Aulia Alfafa , Yusuf Ah , Dian Tristiana Rr
Published: October 2020

Introduction: Marriage with a spouse who has a mental disorder is not easy. Many couples divorce when married with mental disorder patients because they feel difficulties in their marital relationships, but some of them can maintain it for years. The purpose of this research is to describe family functioning in mental disorders.Method: The design of this study was cross-sectional. The sample was 31 wives of people with mental disorder and they were obtained using an accidental sampling technique. The instrument of this research are Family Assessment Device and The Investment Model Scale then analyzed with Pearson correlation test (α < 0,05). Results: There was a significant relationship between family functioning with marital commitment (p = 0,022; r = 0,411). Conclusion: The higher of family functioning then the higher of marital commitment experienced by wives of people with a mental disorder. This finding can be used as a consider in improving mental health nursing services to wives of people with a mental disorder by providing adequate information through counseling about mental disorder and the treatment.
E-learning in the Department of Library Science of UIN Alauddin Makassar Based on Claroline
Authors: Mathar Taufiq , Akbar A. Khaidir , Arifin Nur
Published: October 2020

Background of the study: Since established in 1999, the Department of Library Science of Universitas Islam Negeri (UIN) Alauddin Makassar has been teaching its degree students throughout conventional way of teaching, in which whiteboards and classrooms are still mostly used as learning media till current days. The department challenges with the growing education technology, media such as e-learning.Purpose: This paper is aimed to describe the strategic planning to build and implement an e-learning in the department and to configure e-learning software called Claroline.Method: The data were gathered by discussing with all lecturers and several students as the basic sources to plan and build e-learning.Findings: As the research findings, Panrita 4.0 was determined as its e-learning’s name in order to make the engaged users (lecturers and students) be more familiar with.Conclusion: In addition, the study highlighted challenges faced by most lecturers in implementing such learning media although trainings have been conducted. However, most students were more enjoy learning with Panrita 4.0, even though it was their first experience dealing with such media.
Motivation and Awareness of Institutional Repositories by Students of Yogyakarta Islamic University of Yogyakarta and Yogyakarta State University
Authors: Sembiring Santana
Published: October 2020

Background of the study: Institutional repositories are considered as one of the appropriate tools used by universities to store, preserve, and disseminate the scientific work of students and lecturers. Open access to institutional repositories allows students to access scientific works openly and they can get more complete parts of the work. However, there is another side of the institutional repository that has not received much attention, namely motivation and awareness about institutional repositories. Supported by data on student access to very high institutional repositories, this research was conducted at two universities in Yogyakarta, UII, and UNY.Purpose: This study aims to find out what motivations UII and UNY students to use institutional repositories and what is the awareness of UII and UNY students about institutional repositories.Method: The method used is qualitative with data collection techniques in the form of interviews with six UII and UNY students obtained based on snowball sampling techniques.Findings: The main motivation of UII students to use institutional repositories is to obtain references while the motivation of UNY students is because the institutional repositories are easy to use tools. In terms of awareness, UII and UNY students have a different awareness about institutional repositories which lie in knowledge, semester, understanding, medium, and willingness to store academic work in institutional repositories.Conclusion: Motivation and awareness are the two main keys that students must possess to succeed in the sustainability of the institution's repository.
A Hybrid Approach: Dynamic Diagnostic Rules for Sensor Systems in Industry 4.0 Generated by Online Hyperparameter Tuned Random Forest
Authors: Mallak Ahlam , Fathi Madjid
Published: October 2020

In this work, A hybrid component Fault Detection and Diagnosis (FDD) approach for industrial sensor systems is established and analyzed, to provide a hybrid schema that combines the advantages and eliminates the drawbacks of both model-based and data-driven methods of diagnosis. Moreover, spotting the light on a new utilization of Random Forest (RF) together with model-based diagnosis, beyond its ordinary data-driven application. RF is trained and hyperparameter tuned using 3-fold cross-validation over a random grid of parameters using random search, to finally generate diagnostic graphs as the dynamic, data-driven part of this system. Followed by translating those graphs into model-based rules in the form of if-else statements, SQL queries or semantic queries such as SPARQL, in order to feed the dynamic rules into a structured model essential for further diagnosis. The RF hyperparameters are consistently updated online using the newly generated sensor data, in order to maintain the dynamicity and accuracy of the generated graphs and rules thereafter. The architecture of the proposed method is demonstrated in a comprehensive manner, as well as the dynamic rules extraction phase is applied using a case study on condition monitoring of a hydraulic test rig using time series multivariate sensor readings.
An Outline of the Basic Theory of Accident Science based on the Safety Science Methodology in Risk Process
Authors: Luo Tongyuan , Wu Chao
Published: October 2020

In order to establish a new discipline specializing in accident science from the perspective of safety science. Under the guidance of the current research theories and methods of safety science, combined with the research paradigm of humanities and social medicine, this paper puts forward new viewpoints, new theories and new models about accident research. First of all, through literature retrieval, this paper analyzes the relevant research results of accidents at home and abroad, and expounds the existing problems and the basic trend of accident science research. Secondly, it puts forward eight kinds of attribute relations of the accident, and makes clear the characteristics and connotation of the accident. In the study of accident types, a hierarchical classification model based on accident cognition is created for the first time. It also points out the logical relevance of five levels of accident science research and the realistic relevance of three levels. At the same time, according to the thought of science of science, this paper puts forward a new definition of safety under the thinking of accident science and other basic concepts related to safety science, and explains the connotation. In addition, it creates and constructs the basic concept of accident science, establishes the conceptual model of accident science, and points out the “3-4-5” model of accident science research and its connotation. Thirdly, draw lessons from the interdisciplinary paradigm to study the relevant theoretical basis and discipline classification relationship of accident science, and construct the tree of accident science. Finally, the research contents of three main aspects of accident science are summarized. The results show that the research results in this paper not only play a fundamental role in the basic construction of accident science, but also further enrich and perfect the discipline system of safety science, which has a certain theoretical significance.
Application of Tracer-Based Workflow for Calibrating Reservoir Heterogeneity
Authors: Doorwar Shashvat , Purswani Prakash , Ambastha Anil , Jain Lokendra , Thach Sophany
Published: October 2020

Capturing the correct reservoir heterogeneity in a geological model is critical for designing and accurately forecasting expected production benefits from improved/enhanced oil recovery processes. In simple terms, reservoir heterogeneity is often considered as a measure of statistical variation of static properties, such as porosity and permeability. The Lorenz coefficient and Dykstra-Parsons coefficient are two such measures of reservoir heterogeneity that account for these static effects. These measures are considered simplistic because the spatial distribution and arrangement of these properties is more critical for reservoir characterization than its statistical variation. The dynamic Lorenz coefficient is one such measure that accounts for the spatial distribution and arrangement of porosity and permeability. The dynamic Lorenz coefficient cannot be directly measured in the field but can be implicitly inferred from tracer data. This inferred heterogeneity will be influenced by the spatial distribution of static properties and can also be significantly influenced by multiphase flow effects, such as viscous fingering and gravity over/underride, which often arise from the differences in the viscosities and densities of the different phases involved. The dynamic Lorenz coefficient interpreted from a tracer test response lumps both static and multiphase (dynamic) effects into one measure of heterogeneity. During geological model construction, the dynamic Lorenz coefficient is also used to rank the model in terms of heterogeneity to select the most representative model. However, the geological models are ranked using fast single-phase/streamline simulations and are devoid of complications caused by adverse mobility or density effects. This creates a disconnect between the heterogeneity measures used to characterize a geological model and those available to characterize a reservoir. Thus, calibrating a geological model to field data is a laborious task.

In this paper, we present a workflow that bridges this gap by decoupling the effect of adverse mobility to obtain an approximate measure of heterogeneity that can be cross-checked against the geological realizations to select the most representative model. The workflow developed in this paper is for inverted, seven-spot patterns and is mainly focused on water-wet reservoirs.
A multi-stakeholder approach to the co-production of the research agenda for medicines optimisation
Authors: Fellenor John , Britten Nicky , Courtenay Molly , Payne Rupert A , Valderas Jose , Denholm Rachel , Duncan Polly , McCahon Deborah , Tatnell Lynn , Fitzgerald Richard , Warmoth Krystal , Gillespie David , Turner Katrina , Watson Margaret
Published: October 2020

Background Up to 50% of medicines are not used as intended, resulting in poor health and economic outcomes. Medicines optimisation is ‘a person-centred approach to safe and effective medicines use, to ensure people obtain the best possible outcomes from their medicines’. The purpose of this exercise was to co-produce a prioritised research agenda for medicines optimisation using a multi-stakeholder (patient, researcher, public and health professionals) approach. Methods A three-stage, multiple method process was used including: generation of preliminary research questions (Stage 1) using a modified Nominal Group Technique; electronic consultation and ranking with a wider multi-stakeholder group (Stage 2); a face-to-face, one-day consensus meeting involving representatives from all stakeholder groups (Stage 3). Results In total, 92 research questions were identified during Stages 1 and 2 and ranked in order of priority during stage 3. Questions were categorised into four areas: ‘Patient Concerns’ [e.g. is there a shared decision (with patients) about using each medicine?], ‘Polypharmacy’ [e.g. how to design health services to cope with the challenge of multiple medicines use?], ‘Non-Medical Prescribing’ [e.g. how can the contribution of non-medical prescribers be optimised in primary care?], and ‘Deprescribing’ [e.g. what support is needed by prescribers to deprescribe?]. A significant number of the 92 questions were generated by Patient and Public Involvement representatives, which demonstrates the importance of including this stakeholder group when identifying research priorities. Conclusions A wide range of research questions was generated reflecting concerns which affect patients, practitioners, the health service, as well the ethical and philosophical aspects of the prescribing and deprescribing of medicines. These questions should be used to set future research agendas and funding commissions.
Anthropometric changes in children under 7 years old in Nanjing, China from 1995 to 2015
Authors: Chen Ling , Chen Ying , Dong Jing , Li Xi Ling , Yao Tian Hong , Li Yue , Tong Mei Ling , Zhang Min
Published: October 2020

Background: To date, there have been several reports about long-term changes in physical growth in children of different races around the world. However, limited studies on this change have been reported in Nanjing, China. We decided to assess long-term changes in body weight, length/height and head circumference in children (0-7 years old) in Nanjing over the past two decades from 1995 to 2015 and the relationship between socioeconomic development and the change of physical growth.Methods: The results for body weight, length/height and head circumference in 0-to 7-year-old children were obtained from three repeated cross-sectional surveys that were performed by using the same methods in the same urban and suburban areas of Nanjing in 1995, 2005 and 2015. The differences in mean values between urban and suburban boys and girls and the increases per decade were compared. Socioeconomic indicators were collected and analysed.Results: There was positive long-term growth in height and weight of children in Nanjing from 1995 to 2015, measurements increased 0.3-3.00 kg in weight and 1.0-3.8 cm in height for boys, 0.23-2.18 kg in weight and 1.3-3.6 cm in height for girls in urban areas (except children under 15 months), as well as 0.32-4.15 kg in weight and 1.1-7.4 cm in height for boys, 0.26-2.95 kg in weight and 1.2-6.3 cm in height for girls in suburban areas (except children under 8 months). Compared with the first decade, the changes of mean values in height and weight of urban children in the second decade were smaller. In contrast, the long-term change of suburban children still kept fast growth rate. Before 2.5 years old, negative increases in weight and height in urban children were observed. Urban-suburban difference of weight and height became smaller in 2015. The growth of head circumference from 1995 to 2015 underwent a small long-term change, especially of urban children. Conclusion: The increased long-term physical growth due to rapid social and economic development would disappear, and genetic potential might have been seen. In future, health strategies in Nanjing may focus on controlling rapid weight gain and preventing obesity.
Impact of exercise training on symptoms of depression, physical activity level and social participation in people living with HIV/AIDS: A systematic review and meta-analysis
Authors: Ibeneme Sam Chidi , Uwakwe Victor C , Myezwa Hellen , Irem Franklin Onyedinma , Ezenwankwo Fortune Elochukwu , Ajidahun Tunde Adedayo , Ezuma Amarachi Destiny , Okonkwo Uchenna Prosper , Fortwengel Gerhard
Published: October 2020

Background: Symptoms of depression are prevalent in people living with human immune deficiency virus/acquired immune deficiency syndrome (PLWHA), and worsened by lack of physical activity/exercises, leading to restriction in social participation/functioning. This raises the question: What is the extent to which physical exercise training affected symptoms of depression, physical activity level (PAL) and social participation in PLWHA compared to other forms of interventions, usual care, or no treatment controls? Objectives: To assess the impact of physical exercise training on symptoms of depression, PAL and social participation in PLWHA. Data sources: Eight databases were searched up to July 2020, according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) protocol. Study eligibility criteria: Only randomised controlled trials involving adults who were either on HAART/HAART-naïve and reported in the English language, were included. Data collection and analysis: Two independent reviewers determined the eligibility of the studies, extracted data, assessed their quality, and risk of bias using the Physiotherapy Evidence Database (PEDro) tool. Standardised mean difference (SMD) was used as summary statistics for the mean primary outcome (symptoms of depression) and secondary outcomes (PAL and social participation) since different measuring tools/units were used across the included studies. Summary estimates of effects were determined using a random-effects model (I2). Results: Thirteen studies met the inclusion criteria with 779 participants (n=596 participants on study completion) randomised into the study groups, comprising 378 males, 310 females and 91 participants with undisclosed gender, and with an age range of 18-86 years. Across the studies, aerobic or aerobic plus resistance exercises were performed 2-3 times/week, at 40-60 minutes/session, and for between 6-24 weeks, and the risk of bias varied from high to low. Comparing the intervention to control groups showed significant difference in the symptoms of depression (SMD=-0.74, 95% confidence interval (CI)=-1.01,-0.48,p=<0.0002;I2=47%;5studies; 205participants) unlike PAL (SMD=0.98,95%CI=-0.25,2.17,p=0.11;I2=82%;2studies;62 participants) and social participation (SMD=0.04,95%CI=-0.65,0.73,p=0.91;I2=90%; 6 studies; 373 participants).Conclusion: Physical exercise training could have an antidepressant-like effect in PLWHA but did not affect their PAL and social participation. However, the high heterogeneity in the included studies, imply that adequately powered RCTs with clinical/methodological similarity are required in future studies.Registration number: INPLASY202040048
Quantifying the adhesive strength between the SARS-CoV-2 S-proteins and human receptor and its effect in therapeutics
Authors: Torre Mauricio Ponga de la
Published: October 2020

The binding affinity and adhesive strength between the spike (S) glycoproteins of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the human angiotensin-converting enzyme 2 (ACE2) receptor is computed using molecular dynamics (MD) simulations. The calculations indicate that the binding affinity is eRS= 12.6 +/- 1 kCal mol-1 with a maximum adhesive force of ~102 pN. Our analysis suggests that only 27 (13 in S-protein, 14 in ACE2) residues are active during the initial fusion process between the S-protein and ACE2 receptor. With these insights, we investigated the effect of possible therapeutics in the size and wrapping time of virus particles by reducing the binding energy. Our analysis indicates that this energy has to be reduced significantly, around 50\% or more, to block SARS-CoV-2 particles with radius in the order of R < 60 nm. Our study provides concise target residues and target binding energy reduction between S-proteins and receptors for the development of new therapeutics treatments for COVID-19 guided by computational design.
Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity
Authors: Vanderbeke Lore , Mol Pierre Van , Herck Yannick van , Smet Frederik De , Humblet-Baron Stephanie , Martinod Kimberly , Antoranz Asier , Arijs Ingrid , Boeckx Bram , Bosisio Francesca , Casaer Michael , Dauwe Dieter , Wever Walter De , Dooms Christophe , Dreesen Erwin , Emmaneel Annelies , Filtjens Jessica , Gouwy Mieke , Gunst Jan , Hermans Greet , Jansen Sander , Lagrou Katrien , Liston Adrian , Lorent Natalie , Meersseman Philippe , Mercier Toine , Neyts Johan , Odent Julie , Panovska Dena , Penttila Pier Andree , Pollet Emily , Proost Paul , Qian Junbin , Quintelier Katrien , Raes Jeroen , Rex Steffen , Saeys Yvan , Sprooten Jenny , Tejpar Sabine , Testelmans Dries , Thevissen Karin , Buyten Tina Van , Vandenhaute Jessica , Gassen Sofie Van , Pereira Leydi Velasquez , Vos Robin , Weynand Birgit , Wilmer Alexander , Yserbyt Jonas , Garg Abhishek , Matthys Patrick , Wouters Carine , Lambrechts Diether , Wauters Els , Wauters Joost
Published: October 2020

Epidemiological and clinical reports have indicated that the host immune response to SARS-CoV-2, more so than viral factors, determines COVID-19 disease severity. To elucidate the immunopathology underlying COVID-19 severity, cytokine and multiplex immune profiling was performed in mild-moderate and critically-ill COVID-19 patients. Hypercytokinemia in COVID-19 differed from the IFN-γ-driven cytokine storm in macrophage activation syndrome, and was more pronounced in critical versus mild-moderate COVID-19. Systems modelling of cytokine levels followed by deep-immune profiling showed that classical monocytes drive this hyper-inflammatory phenotype and that a reduction in T-lymphocytes correlates with disease severity, with CD8+ cells being disproportionately affected. Expression of antigen presenting machinery was reduced in critical disease, while also neutrophils contributed to disease severity and local tissue damage by amplifying hypercytokinemia and neutrophil extracellular trap formation. We suggest a myeloid-driven immunopathology, in which hyperactivated neutrophils and an ineffective adaptive immune system act as mediators of COVID-19 disease severity.
The experiences of pregnant and lactating women during the earthquake emergency in Abruzzo: ten years later, what have we learned?
Authors: Giusti Angela , Marchetti Francesca , Zambri Francesca , Pro Elide , Brillo Eleonora , Colaceci Sofia
Published: October 2020

Background

Emergencies have a great impact on infant and young child feeding. Although the evidence, the recommended feeding practices are still not implemented in the emergency response, undermining infant and maternal health. The aim of this study was to explore the experiences of pregnant and lactating women during the earthquake emergency that occurred in L’Aquila on April 6, 2009.
Methods

The study design was qualitative descriptive. Data were collected by individual semi-structured interviews, investigating the mother’s experiences of pregnancy, childbirth, breastfeeding, infant formula or complementary feeding during the emergency and the post emergency phase. Data analysis was categorical and was performed by using N-Vivo software.
Results

Six women who were pregnant at the time of the earthquake were interviewed in January 2010. In addition to the essential needs of pregnant and lactating women, such as those related to the emergency shelters conditions, the main findings emerged from this study were: the reconfiguration of relationships and the central role of partners and family support; the need of spaces for sharing experiences and practices with other mothers; the lack of breastfeeding support after the hospital discharge; the inappropriate donations and distribution of Breast Milk Substitutes.
Conclusions

During and after L’Aquila earthquake, several aspects of infant and young child feeding did not comply with standard practices and recommendations. The response system appeared not always able to address the specific needs of pregnant and lactating women. It is urgent to develop management plans, policies and procedures and provide communication, sensitization, and training on infant and young child feeding at all levels and sectors of the emergency response.
Juvenile fibromyalgia: A call for diagnostic refinement, a case report
Authors: Peterson Elisha , Yao Caylynn , Sule Sangeeta D. , Finkel Julia C.
Published: October 2020

BackgroundFibromyalgia is a clinical syndrome consisting of widespread musculoskeletal tenderness and various somatic complaints including nonrestorative sleep, mood disorders such as anxiety or depression, abdominal pain, and/or headaches. There is a great deal of heterogeneity in its expression which leads to difficulty in identifying predisposing factors. A singular review of patients in an academic pediatric pain clinic reveal immune system dysfunction, mood disorders, infection, postural orthostatic tachycardia syndrome, complex regional pain syndrome, and hypermobility are premorbid conditions. It is unclear if these premorbid conditions confer a distinct fibromyalgia clinical phenotype that can provide insight into targeted therapies. Current diagnostic measures for fibromyalgia do not allow for this level of discrimination and are not validated in children.Case Presentation20 children who demonstrated widespread musculoskeletal pain, tenderness to pressure on exam and multiple somatic complaints were diagnosed with fibromyalgia. Average time from start of pain to diagnosis is 2 years. Over half the patients have psychopathology, a third have an immune system dysfunction related to autoimmunity or an infectious exposure, a third with orthostatic intolerance or postural orthostatic tachycardia syndrome, a quarter relating to hypermobility, and a quarter of the cohort with dysmenorrhea were pre or comorbid conditions. Effective therapeutic regimens among patients varied widely from responding to medical monotherapy to multimodal treatment. Trigger point injections worsened pain in one fibromyalgia patient but decreased pain in another. Patients with comorbid autoimmunity report appreciating a difference between a flare in their arthritis as opposed to a flare in their fibromyalgia. Such varying responses within the same clinical syndrome suggest distinct phenotypes within fibromyalgia which is difficult to distinguish using our current diagnostic tools.ConclusionThere is a need for clear diagnostic criteria for both the recognition of juvenile fibromyalgia and tools to distinguish phenotypes within fibromyalgia. Currently, the recognition of clinical symptoms renders it an often-overlooked neuropathic pain condition. This case series suggest there are different phenotypes within fibromyalgia. Some patients respond remarkably to serotonin norepinephrine reuptake inhibitors alone whereas others require multidisciplinary therapy. A diagnostic tool refined to capture these nuances can facilitate targeted treatment recommendations.