bluuebunny/crossref_metadata_2025 huggingface dataset:
MetaFetcheR: An R Package for Complete Mapping of Small-Compound Data
Authors: Yones Sara A. , Csombordi Rajmund , Komorowski Jan , Diamanti Klev
Published: October 2021

Small-compound databases contain a large amount of information for metabolites and metabolic pathways. However, the plethora of such databases and the redundancy of their information lead to major issues with analysis and standardization. A lack of preventive establishment of means of data access at the infant stages of a project might lead to mislabelled compounds, reduced statistical power, and large delays in delivery of results. We developed MetaFetcheR, an open-source R package that links metabolite data from several small-compound databases, resolves inconsistencies, and covers a variety of use-cases of data fetching. We showed that the performance of MetaFetcheR was superior to existing approaches and databases by benchmarking the performance of the algorithm in three independent case studies based on two published datasets.
Design and Characterization of Maltoheptaose-b-Polystyrene Nanoparticles, as a Potential New Nanocarrier for Oral Delivery of Tamoxifen
Authors: Villetti Marcos Antonio , Clementino Adryana Rocha , Dotti Ilaria , Ebani Patricia Regina , Quarta Eride , Buttini Francesca , Sonvico Fabio , Bianchera Annalisa , Borsali Redouane
Published: October 2021

Tamoxifen citrate (TMC), a non-steroidal antiestrogen drug used for the treatment of breast cancer, was loaded in a block copolymer of maltoheptaose-b-polystyrene (MH-b-PS) nanoparticles, a potential drug delivery system to optimize oral chemotherapy. The nanoparticles were obtained from self-assembly of MH-b-PS using the standard and reverse nanoprecipitation methods. The MH-b-PS@TMC nanoparticles were characterized by their physicochemical properties, morphology, drug loading and encapsulation efficiency, and release kinetic profile in simulated intestinal fluid (pH 7.4). Finally, their cytotoxicity towards the human breast carcinoma MCF-7 cell line was assessed. The standard nanoprecipitation method proved to be more efficient than reverse nanoprecipitation to produce nanoparticles with small size and narrow particle size distribution. Moreover, tamoxifen-loaded nanoparticles displayed spherical morphology, a positive zeta potential and high drug content (238.6 ± 6.8 µg mL−1) and encapsulation efficiency (80.9 ± 0.4 %). In vitro drug release kinetics showed a burst release at early time points, followed by a sustained release profile controlled by diffusion. MH-b-PS@TMC nanoparticles showed higher cytotoxicity towards MCF-7 cells than free tamoxifen citrate, confirming their effectiveness as a delivery system for administration of lipophilic anticancer drugs.
Purification of Chlorophenol Isomers by Stripping Crystallization Combining Melt Crystallization and Vaporization
Authors: Shiau Lie-Ding
Published: October 2021

Stripping crystallization (SC) was introduced in this work to purify p-chlorophenol from the p-chlorophenol-rich liquid mixture and to purify m-chlorophenol from the m-chlorophenol-rich liquid mixture, respectively. Essentially, SC combines melt crystallization and vaporization to produce the solid product and the vapor from a liquid mixture via a series of three-phase transformations at reduced pressures during the cooling process. At the end of the SC, only the solid product remained while the liquid mixture was almost eliminated and the produced vapor was removed. A set of differential equations based on the mass and energy balances were proposed to determine the incremental variations of the amounts of remaining liquid, produced solid and produced vapor during the batch SC process. The experimental yield and product purity of the final product obtained from the batch SC experiments were compared with those predicted by the model.
RNA Activation—A Novel Approach to Therapeutically Upregulate Gene Transcription
Authors: Tan Choon Ping , Sinigaglia Laura , Gomez Valentí , Nicholls Joanna , Habib Nagy A.
Published: October 2021

RNA activation (RNAa) is a mechanism whereby RNA oligos complementary to genomic sequences around the promoter region of genes increase the transcription output of their target gene. Small activating RNA (saRNA) mediate RNAa through interaction with protein co-factors to facilitate RNA polymerase II activity and nucleosome remodeling. As saRNA are small, versatile and safe, they represent a new class of therapeutics that can rescue the downregulation of critical genes in disease settings. This review highlights our current understanding of saRNA biology and describes various examples of how saRNA are successfully used to treat various oncological, neurological and monogenic diseases. MTL-CEBPA, a first-in-class compound that reverses CEBPA downregulation in oncogenic processes using CEBPA-51 saRNA has entered clinical trial for the treatment of hepatocellular carcinoma (HCC). Preclinical models demonstrate that MTL-CEBPA reverses the immunosuppressive effects of myeloid cells and allows for the synergistic enhancement of other anticancer drugs. Encouraging results led to the initiation of a clinical trial combining MTL-CEBPA with a PD-1 inhibitor for treatment of solid tumors.
Support Induced Effects on the Ir Nanoparticles Activity, Selectivity and Stability Performance under CO2 Reforming of Methane
Authors: Nikolaraki Ersi , Goula Grammatiki , Panagiotopoulou Paraskevi , Taylor Martin J. , Kousi Kalliopi , Kyriakou Georgios , Kondarides Dimitris I. , Lambert Richard M. , Yentekakis Ioannis V.
Published: October 2021

The production of syngas (H2 and CO)—a key building block for the manufacture of liquid energy carriers, ammonia and hydrogen—through the dry (CO2−) reforming of methane (DRM) continues to gain attention in heterogeneous catalysis, renewable energy technologies and sustainable economy. Here we report on the effects of the metal oxide support (γ-Al2O3, alumina-ceria-zirconia (ACZ) and ceria-zirconia (CZ)) on the low-temperature (ca. 500–750 ∘C) DRM activity, selectivity, resistance against carbon deposition and iridium nanoparticles sintering under oxidative thermal aging. A variety of characterization techniques were implemented to provide insight into the factors that determine iridium intrinsic DRM kinetics and stability, including metal-support interactions and physicochemical properties of materials. All Ir/γ-Al2O3, Ir/ACZ and Ir/CZ catalysts have stable DRM performance with time-on-stream, although supports with high oxygen storage capacity (ACZ and CZ) promoted CO2 conversion, yielding CO-enriched syngas. CZ-based supports endow Ir exceptional anti-sintering characteristics. The amount of carbon deposition was small in all catalysts, however decreasing as Ir/γ-Al2O3 > Ir/ACZ > Ir/CZ. The experimental findings are consistent with a bifunctional reaction mechanism involving participation of oxygen vacancies on the support’s surface in CO2 activation and carbon removal, and overall suggest that CZ-supported Ir nanoparticles are promising catalysts for low-temperature dry reforming of methane (LT-DRM).
Dielectric Fluids for Power Transformers with Special Emphasis on Biodegradable Nanofluids
Authors: Šárpataky Miloš , Kurimský Juraj , Rajňák Michal
Published: October 2021

This review is focused on the research of dielectric fluids, especially commonly used power transformer oils enhanced by nanoparticles, i.e., nanofluids. There are differences between various combinations of base fluids and nanoparticles prepared in different ways. The main goal of this review was to present recent research in this field sorted by the used nanoparticles. Nanofluids based on mineral oils, natural, or synthetic esters were investigated in terms of the nature of nanoparticles, particularly Al2O3, TiO2, Fe2O3, Fe3O4, graphene, fullerene, and others. The combinations of environmentally friendly oils and nanoparticles were presented. Finally, the article focused on the description of current dielectric fluids usable in power transformers and the possibilities of improving new and existing fluids with nanoparticles, especially their physical, dielectric, and chemical properties, but with regard to environmental aspects.
Peptide Specific Nanoplastic Detection Based on Sandwich Typed Localized Surface Plasmon Resonance
Authors: Oh Seungju , Hur Hyeyeon , Kim Yoonjae , Shin Seongcheol , Woo Hyunjeong , Choi Jonghoon , Lee Hyun Ho
Published: October 2021

Recently, various waste microplastics sensors have been introduced in response to environmental and biological hazards posed by waste microplastics. In particular, the detrimental effects of nano-sized plastics or nanoplastics have been reported to be severe. Moreover, there have been many difficulties for sensing microplastics due to the limited methodologies for selectively recognizing nanoplastics. In this study, a customized gold nanoparticles (Au NPs) based localized surface plasmon resonance (LSPR) system having bio-mimicked peptide probes toward the nanoplastics was demonstrated. The specific determination through the oligo-peptide recognition was accomplished by chemical conjugation both on the LSPR chip’s 40~50 nm Au NPs and sandwiched 5 nm Au NPs, respectively. The peptide probe could selectively bind to polystyrene (PS) nanoplastics in the forms of fragmented debris by cryo-grinding. A simple UV-Vis spectrophotometer was used to identify the LSPR sensing by primarily measuring the absorbance change and shift of absorption peak. The sandwich-binding could increase the LSPR detection sensitivity up to 60% due to consecutive plasmonic effects. In addition, microwave-boiled DI water inside of a styrofoam container was tested for putative PS nanoplastics resource as a real accessible sample. The LSPR system could be a novel protocol overcoming the limitations from conventional nanoplastic detection.
Multifunctional Nanopolymers for Blood–Brain Barrier Delivery and Inhibition of Glioblastoma Growth through EGFR/EGFRvIII, c-Myc, and PD-1
Authors: Patil Rameshwar , Sun Tao , Rashid Mohammad Harun , Israel Liron L. , Ramesh Arshia , Davani Saya , Black Keith L. , Ljubimov Alexander V. , Holler Eggehard , Ljubimova Julia Y.
Published: October 2021

Glioblastoma (GBM) is the most prevalent primary brain cancer in the pediatric and adult population. It is known as an untreatable tumor in urgent need of new therapeutic approaches. The objective of this work was to develop multifunctional nanomedicines to treat GBM in clinical practice using combination therapy for several targets. We developed multifunctional nanopolymers (MNPs) based on a naturally derived biopolymer, poly(β-L-malic) acid, which are suitable for central nervous system (CNS) treatment. These MNPs contain several anticancer functional moieties with the capacity of crossing the blood–brain barrier (BBB), targeting GBM cells and suppressing two important molecular markers, tyrosine kinase transmembrane receptors EGFR/EGFRvIII and c-Myc nuclear transcription factor. The reproducible syntheses of MNPs where monoclonal antibodies are replaced with AP-2 peptide for effective BBB delivery were presented. The active anticancer inhibitors of mRNA/protein syntheses were Morpholino antisense oligonucleotides (AONs). Two ways of covalent AON-polymer attachments with and without disulfide bonds were explored. These MNPs bearing AONs to EGFR/EGFRvIII and c-Myc, as well as in a combination with the polymer-attached checkpoint inhibitor anti-PD-1 antibody, orchestrated a multi-pronged attack on intracranial mouse GBM to successfully block tumor growth and significantly increase survival of brain tumor-bearing animals.
Correction: Fan et al. Efficacy of Ingesting an Oral Rehydration Solution after Exercise on Fluid Balance and Endurance Performance. Nutrients 2020, 12, 3826
Authors: Fan Priscilla Weiping , Burns Stephen F. , Lee Jason Kai Wei
Published: October 2021

The authors would like to make a correction in a recent published paper [...]
Factors Influencing Changes in Food Preparation during the COVID-19 Pandemic and Associations with Food Intake among Japanese Adults
Authors: Hayashi Fumi , Takemi Yukari
Published: October 2021

The primary aim of this study was to evaluate factors associated with changes in food-preparation practices during the Coronavirus Disease 2019 (COVID-19) pandemic in Japan and its associations to food-group intake. To examine this, a cross-sectional online survey was conducted in July 2020. Participants were 2285 adults aged 20–69 years who resided in any of 13 prefectures in Japan where specific COVID-19 regulations had been implemented. Self-reported changes in food-preparation practices when compared to the pre-COVID-19 pandemic period were measured as “increased” (24.6%), “decreased” (7.3%), and “no change” (68.1%), respectively. Stepwise logistic regression analyses indicated that participants who increased the time and effort for food preparation were younger in age, partially working remotely, experiencing reduced household income due to COVID-19, but highly concerned the importance of diet. On the other hand, participants whose household income decreased, and household economic status worsened, as well as those whose importance of diet deteriorated due to COVID-19 were more likely to decrease time and effort for cooking. Although the increased group were more likely to prepare meals with raw ingredients, the decreased group showed higher frequency of using takeout. These results indicated major determinants of changes in time spending on food preparation in consequence of COVID-19, and highlighted essential targets for future nutrition education.
Multifunctional Optical Device with a Continuous Tunability over 500 nm Spectral Range Using Polymerized Cholesteric Liquid Crystals
Authors: Jeong Mi-Yun , Choi Hyeon-Jong , Kwak Keumcheol , Yu Younghun
Published: October 2021

We report that polymerization makes a robust, practically applicable multifunctional optical device with a continuous wavelength tunable over 500 nm spectral range using UV-polymerizable cholesteric liquid crystals (CLCs). It can be used as a circular polarizer generating an extremely high degree of circularly polarized light with |g| = 1.85~2.00. It can also be used for optical notch filters, bandwidth-variable (from ~28 nm to ~93 nm) bandpass filters, mirrors, and intensity-variable beam splitters. Furthermore, this CLC device shows excellent stability owing to the polymerization of CLC cells. Its performance remains constant for a long time (~2 years) after a high-temperature exposure (170 °C for 1 h) and an extremely high laser beam intensity exposure (~143 W/cm2 of CW 532 nm diode laser and ~2.98 MW/cm2 of Nd: YAG pulse laser operation for two hours, respectively). The optical properties of polymerized CLC were theoretically analyzed by Berreman’s 4 × 4 matrix method. The characteristics of this device were significantly improved by introducing an anti-reflection layer on the device. This wavelength-tunable and multifunctional device could dramatically increase optical research efficiency in various spectroscopic works. It could be applied to many instruments using visible and near-infrared wavelengths.
Physical Properties of Shellac Material Used for Hot Melt Extrusion with Potential Application in the Pharmaceutical Industry
Authors: Yan Guangming , Cao Zhi , Devine Declan , Penning Manfred , Gately Noel M.
Published: October 2021

Hot melt extrusion offers an efficient way of increasing the solubility of a poorly soluble drug. Shellac has potential as a pharmaceutical matrix polymer that can be used in this extrusion process, with further advantages for use in enteric drug delivery systems. The rheological property of a material affects the extrusion process conditions. However, the literature does not refer to any published work that investigates the processability of various shellac materials. This work explores various types of shellac and explores their physicochemical and thermal properties along with their processability in the hot melt extrusion application. Physicochemical characterization of the materials was achieved using differential scanning calorimetry, Fourier transform infrared spectroscopy, scanning electron microscopy and energy-dispersive X-ray spectroscopy. Additional processability characterization was achieved using melt flow index and rheology analysis. The results indicated that there was no chemical difference between the various shellac types compared in this study. However, the extrudable temperature ranges and rheological properties of different shellac types varied; SSB 55 Pharma FL had the lowest processing temperature and glass transition temperatures. Due to the shear-thinning behaviours, shellac can be extruded at lower temperatures. This study provides necessary data to determine the processing conditions in hot melt extrusion applications for the range of shellac materials.
3D-Printed Graphene-Based Bow-Tie Microstrip Antenna Design and Analysis for Ultra-Wideband Applications
Authors: Avşar Aydın Emine
Published: October 2021

In this study, the effects of graphene and design differences on bow-tie microstrip antenna performance and bandwidth improvement were investigated both with simulation and experiments. In addition, the conductivity of graphene can be dynamically tuned by changing its chemical potential. The numerical calculations of the proposed antennas at 2–10 GHz were carried out using the finite integration technique in the CST Microwave Studio program. Thus, three bow-tie microstrip antennas with different antenna parameters were designed. Unlike traditional production techniques, due to its cost-effectiveness and easy production, antennas were produced using 3D printing, and then measurements were conducted. A very good match was observed between the simulation and the measurement results. The performance of each antenna was analyzed, and then, the effects of antenna sizes and different chemical potentials on antenna performance were investigated and discussed. The results show that the bow-tie antenna with a slot, which is one of the new advantages of this study, provides a good match and that it has an ultra-bandwidth of 18 GHz in the frequency range of 2 to 20 GHz for ultra-wideband applications. The obtained return loss of −10 dB throughout the applied frequency shows that the designed antennas are useful. In addition, the proposed antennas have an average gain of 9 dBi. This study will be a guide for microstrip antennas based on the desired applications by changing the size of the slots and chemical potential in the conductive parts in the design.
Fabrication of 3D Printed Poly(lactic acid)/Polycaprolactone Scaffolds Using TGF-β1 for Promoting Bone Regeneration
Authors: Cheng Cheng-Hsin , Shie Ming-You , Lai Yi-Hui , Foo Ning-Ping , Lee Mon-Juan , Yao Chun-Hsu
Published: October 2021

Our research was designed to evaluate the effect on bone regeneration with 3-dimensional (3D) printed polylactic acid (PLA) and 3D printed polycaprolactone (PCL) scaffolds, determine the more effective option for enhancing bone regeneration, and offer tentative evidence for further research and clinical application. Employing the 3D printing technique, the PLA and PCL scaffolds showed similar morphologies, as confirmed via scanning electron microscopy (SEM). Mechanical strength was significantly higher in the PLA group (63.4 MPa) than in the PCL group (29.1 MPa) (p < 0.01). Average porosity, swelling ratio, and degeneration rate in the PCL scaffold were higher than those in the PLA scaffold. SEM observation after cell coculture showed improved cell attachment and activity in the PCL scaffolds. A functional study revealed the best outcome in the 3D printed PCL-TGF-β1 scaffold compared with the 3D printed PCL and the 3D printed PCL-Polydopamine (PDA) scaffold (p < 0.001). As confirmed via SEM, the 3D printed PCL- transforming growth factor beta 1 (TGF-β1) scaffold also exhibited improved cell adhesion after 6 h of cell coculture. The 3D printed PCL scaffold showed better physical properties and biocompatibility than the 3D printed PLA scaffold. Based on the data of TGF-β1, this study confirms that the 3D printed PCL scaffold may offer stronger osteogenesis.
Effect of Strain Rate and Silica Filler Content on the Compressive Behavior of RTM6 Epoxy-Based Nanocomposites
Authors: Elmahdy Ahmed , Zotti Aldobenedetto , Zuppolini Simona , Zarrelli Mauro , Borriello Anna , Verleysen Patricia
Published: October 2021

The aim of this paper is to investigate the effect of strain rate and filler content on the compressive behavior of the aeronautical grade RTM6 epoxy-based nanocomposites. Silica nanoparticles with different sizes, weight concentrations and surface functionalization were used as fillers. Dynamic mechanical analysis was used to study the glass transition temperature and storage modulus of the nanocomposites. Using quasi-static and split Hopkinson bar tests, strain rates of 0.001 s−1 to 1100 s−1 were imposed. Sample deformation was measured using stereo digital image correlation techniques. Results showed a significant increase in the compressive strength with increasing strain rate. The elastic modulus and Poisson’s ratio showed strain rate independency. The addition of silica nanoparticles marginally increased the glass transition temperature of the resin, and improved its storage and elastic moduli and peak yield strength for all filler concentrations. Increasing the weight percentage of the filler slightly improved the peak yield strength. Moreover, the filler’s size and surface functionalization did not affect the resin’s compressive behavior at different strain rates.
Can Esports Substitute Traditional Sports? The Convergence of Sports and Video Gaming during the Pandemic and Beyond
Authors: Pu Haozhou , Kim Jeeyoon , Daprano Corinne
Published: October 2021

This research examines the various ways that video games, particularly esports, have been leveraged for content production and fan engagement (i.e., gamification) in traditional sports during the COVID-19 pandemic, as well as sports fans’ reactions in relation to their motives, points of attachment, and other consumer behavior. The study presents a sports–gaming convergence framework and identifies six popular gamification modes where video games and traditional sports converge during the pandemic. The survey results further reveal that gamification content is not consumed as simply a “substitute” for traditional sports, but instead a complementary yet unique product. In conclusion, we suggest that it is critical to recognize the differences between fans of video games and fans of traditional sports concerning market segmentation. Nevertheless, esports could effectively bridge these two industries and their consumers by enriching the content offering and extending distribution channels.
Differences in the Proportional Contributions of Particulate Radiocesium Sources under Base- and High-Flow River Conditions: A Case Study in the Central Region of Fukushima
Authors: Arai Hirotsugu , Fujita Kazuki , Yoshita Hirofumi , Taniguchi Keisuke
Published: October 2021

Due to the Fukushima Daiichi Nuclear Power Plant accident in 2011, large amounts of radiocesium were deposited over forest ecosystems in the headwater regions of rivers in Fukushima Prefecture, Japan. There is considerable concern about whether the runoff from these regions will result in recontamination of lower-lying areas further downstream after heavy rainfall events and typhoons. This study examined the sources and levels of cesium-137 (137Cs), the most abundant radioisotope in river sediments, in total suspended solids (TSS) in river water. In addition, changes in the predominant source of TSS associated with changes in river conditions were investigated. The properties of total organic carbon (TOC) in TSS (concentrations and isotopic compositions) were also measured to identify differences among sources. The results showed reductions in 137Cs and TOC properties in TSS when the river conditions changed from base flows to high flows, indicating the existence of a dilution effect through the addition of mineral particles from extraneous sources. Simulation results obtained using a mixing model suggested that forest soils are the primary source of TSS regardless of river conditions, but that the relative contribution of TSS from forest soils was decreased under high-flow conditions. Meanwhile, the relative contributions of both riverbank soil and river sediments were increased under high-flow conditions. Due to the low 137Cs concentrations in riverbank soils and river sediments, it is unlikely that heavy rainfall events will cause serious recontamination of areas downstream in the study area.
Parsimonious Models of Precipitation Phase Derived from Random Forest Knowledge: Intercomparing Logistic Models, Neural Networks, and Random Forest Models
Authors: Campozano Lenin , Robaina Leandro , Gualco Luis Felipe , Maisincho Luis , Villacís Marcos , Condom Thomas , Ballari Daniela , Páez Carlos
Published: October 2021

The precipitation phase (PP) affects the hydrologic cycle which in turn affects the climate system. A lower ratio of snow to rain due to climate change affects timing and duration of the stream flow. Thus, more knowledge about the PP occurrence and drivers is necessary and especially important in cities dependent on water coming from glaciers, such as Quito, the capital of Ecuador (2.5 million inhabitants), depending in part on the Antisana glacier. The logistic models (LM) of PP rely only on air temperature and relative humidity to predict PP. However, the processes related to PP are far more complex. The aims of this study were threefold: (i) to compare the performance of random forest (RF) and artificial neural networks (ANN) to derive PP in relation to LM; (ii) to identify the main drivers of PP occurrence using RF; and (iii) to develop LM using meteorological drivers derived from RF. The results show that RF and ANN outperformed LM in predicting PP in 8 out of 10 metrics. RF indicated that temperature, dew point temperature, and specific humidity are more important than wind or radiation for PP occurrence. With these predictors, parsimonious and efficient models were developed showing that data mining may help in understanding complex processes and complements expert knowledge.
Evaluation of Drainage Water Detention Efficiency of Off-Line Ditch-Pond Systems and Its Influencing Factors
Authors: Shen Tao , Wang Rao , Jiao Pingjin , Wang Youzhen
Published: October 2021

Ditch-pond systems can effectively alleviate the adverse effects of agricultural drainage on downstream canals and flood control in downstream areas. In this study, peak flow reduction rate (PFR) and drainage volume detention rate (DVD) are used to evaluate the effectiveness of an off-line ditch-pond system for reducing peak flow, retarding agricultural drainage water, and examining the key influencing factors. The results show that the PFR and DVD of the off-line ditch-pond system are significantly affected by three parameters: weir depth (Ld), weir width (Lw), and pond area-to-drainage area ratio (Ksp). Both the PFR and DVD increase with the increase in Ld, Lw, and Ksp. The effects of Ld and Lw on the PFR and the DVD are significant, whereas that Ksp is relatively small. Adjusting Ld and Lw increases both the PFR and DVD up to 80%. Specifically, Ld contributes 75% of the variations in the PFR and the DVD, and Lw affects only 17% of the PFR variations and 11% of the DVD variations. These findings confirm that an off-line ditch-pond system can be effectively used for the detention of agricultural drainage water. Thus, when such a system is designed with an appropriate diversion weir, the impact of agricultural drainage water on downstream canals and downstream areas can be reduced remarkably.
BIOPOLITICS AND BIOPOWER: THE ESSENCE OF CONCEPTS IN SOCIAL AND PHILOSOPHICAL DIMENSIONS
Authors: Shapovalova Iryna
Published: October 2021

The first definition of biopolitics M. Foucault offered in a series of his lectures on "It is necessary to protect society", which he gave to students at the Collège de France in 1975-1976. Under biopolitics, the scientist understood "a set of processes that include the proportion of births and deaths, the level of reproduction, population growth" [11, p. 257]. It should be noted that in M. Foucault's concept, biopolitics is meaningfully connected with biopower. Central to the concept of biopolitics (biopower) is the state, which provides the conditions for the reproduction of the population, supports its livelihoods and pursues policies in the health care system. Further conceptualization of the phenomena of biopolitics and biopower is due to the research efforts of J. Agamben, A. Negri and many other scientists. According to scholars, the power constructs of bourgeois society and capitalist relations of the late eighteenth century. - early XIX century ensured the socialization of the human body as a labor force and an element of the production process. Society's control over man began to be exercised not only through consciousness, ideology, "but also in the body and with the body." The human body has come to be seen as a biopolitical reality, and medicine with its technology as a political strategy. It should be noted that biopolitics (biopower) is a unique and extremely dynamic phenomenon that is undergoing constant transformation, which causes a constant expansion of the semantic range of biopolitics and biopower in modern social and philosophical discourse.
FROM BOOLE’S LOGIC TO BOOLEAN APPLICATIONS IN COMPUTER SCIENCE
Authors: Awwad Mohamad
Published: October 2021

The developments of an algebraic logical language of thoughts by G. Boole are considered using historical and theoretical perspectives. The technical implementations of Boolean logic in combinational circuits and in modern cryptography show strong influences of a 19th century logic on the latest technologies of computing.
FEATURES OF THE ORGANIZATION OF BLENDED LEARNING WITH THE USE OF DIGITAL TECHNOLOGIES
Authors: Marienko Maiia , Sukhikh Alisa
Published: October 2021

The domestic experience of the introduction of distance and blended learning in secondary schools of Ukraine is presented. In particular, combinations of various forms and systems of education are established. The experience of using digital technologies is reflected (mainly within the framework of distance learning organization). Criteria for selecting digital technologies for the implementation of blended learning in general secondary education: forms of presentation of educational material and multimedia, the structure of information presentation, interaction with educational content, variability of educational content.
APPLICATION OF COMPUTER MODELING POSSIBILITIES IN THE STUDY OF PHYSICAL MODELS
Authors: Kindrat Pavlo , Voitovych Ihor , Mashchenko Vladimir
Published: October 2021

The advantages and disadvantages of using a virtual laboratory and computer models in the educational process in physics are identified. The expediency of using virtual laboratories and computer models in the context of mixed physics education is substantiated. To teach future physics teachers to create and use computer models of physical phenomena and processes is carried out in a professionally oriented author's course "Methods of using computer technology in professional activities." The stages of development of a physical model for the formulation of a mathematical problem are described and the implementation on the example of development and use of the program "Dynamic model of an ideal gas" is shown.
PARTICULARITIES OF COMMUNICATIVE INTERACTION OF SUBJECTS OF PEDAGOGICAL PROCESS IN THE EDUCATIONAL ENVIRONMENT WITH THE APPLICATION OF REMOTE TECHNOLOGIES
Authors: Zadorozhna Olha
Published: October 2021

The learning situation is first of all revealed as a situation of communicative interaction.
The difficulties of communication lie in the essence of distance learning, namely in the fact that its subjects are divided in space and possibly in time.
When organizing the communicative interaction of the subjects of the pedagogical process in the educational environment with the use of remote technologies, it becomes especially important to create appropriate conditions for the development of the subjective position of students through updating and enriching of their own subjective experience (appeal to previously accumulated knowledge and skills to the use of different methods and independent choice of the task, creating situations of moral choice, encouraging the search for non-standard options for solving cognitive issues (problems), the organization of cognition through experience, the actualization of sensory experience, etc.); development of action in educational activity (encouragement of initiative, creation of situations of choice, organization of project activity, etc.).
Pengembangan Sistem Informasi Pencatatan Riwayat Dan Notifikasi Penjadwalan Donor Darah Berbasis Website Menggunakan Framework Codeigniter
Authors: Widiastuti Rosalina Yani , Setyawati Endang , Langobelen Angela Marici Uba
Published: October 2021

The Indonesian Red Cross is a national association organization in Indonesia that is engaged in the social and humanitarian field. One of PMI's main activities is blood donation. Currently, in handling the need for blood donors, UDD PMI Banyumas Regency has a system that helps in the donor process, namely SIMDONAR. SIMDONAR is an information system from the central IT provided to UDD PMI Banyumas Regency in the operation of blood donors, but in some aspects of blood donation, such as donor recording and notification of donor scheduling to donors, there is still no available so that it can run efficiently. Data collection in the blood donor history recording system still cannot be recorded properly, causing donors to also not be able to know the history of the last donor, when and how many times the donor has donated, there is also no notification of blood donor scheduling for donors, this makes the information conveyed to donors is incomplete so that donors are confused in taking action when to donate again. Therefore, to support the smooth running of the blood donor system, it is necessary to rebuild an appropriate information system that can provide a solution for the process of recording blood donation history at UDD PMI Banyumas Regency. The purpose of this system is to provide accurate and efficient information related to blood donation history records, and scheduling notifications to officers and donors. The benefit of this system is that it helps provide information related to donor history records for UDD PMI Banyumas Regency so that they can find out donor history records from donors, also helps donors to find out donor history or how many times the donor has donated blood. In this case, the system development method uses the prototype model method. Based on the results of the benefit test, the average value of the Efficiency value is 98.33%, the Usability value is 94.33%, the Correctness value is 95.56%, the Integrity value is 96.67%, and the Testability value is 96.67%. From the results of the benefit test, it can be concluded that the development of this system can be applied and used to facilitate the process of recording blood donor history and notification of blood donor scheduling at UDD PMI Banyumas Regency.
Kewenangan Kurator Dalam Pengurusan Dan Pemberesan Harta Pailit Dalam Hal Negara Sebagai Kreditor Preferen
Authors: Keliat Venia Utami , Sunarmi Sunarmi , Nasution Bismar , Azwar T. Devi Keizerina
Published: October 2021

In handling and settling of bankruptcy debtor wealth is carried out by the curator under the supervision of a judge with the main objective of using the sale of these assets to pay all debts of the bankrupt debtor proportionally (prorate parta) and based on the structure. The existence of a state towards a bankrupt company in collecting tax which is a state right. With the Constitutional Court Verdict No. 67 / PUU-XI / 2013 results in uncertainty. Which should be paid first, tax debt or labor wages. Therefore a problem arises namely what is the responsibility of the curator in handling and settlement of bankrupt assets, how Law Number 37 of 2004 Concerning Bankruptcy and Delaying Obligations of Debt Payment in protecting the duties of the curator in terms of handling and settlement bankrupt assets, how is the State's position as the preferred creditor after the Constitutional Court's verdict No. 67 / PUU-XI / 2013. The type of writing method applied in this research is normative legal research. The method of approach used is the method of legislation approach using primary, secondary and tertiary legal materials. The data needed is collected by means of library research and field research by conducting interviews and then analyzed by qualitative deductive analysis methods to produce descriptive data. Based on the results of the study it can be concluded that the. The curator cannot be punished if he has carried out his duties according to the Judge's provisions. The dispute over the right to precede only arises when there are bills for labor wages and tax debts all at once.
Implementasi Kebijakan Program Komando Strategis Pembangunan Pertanian (Kostratani) di Kecamatan Sukodono Kabupaten Sidoarjo
Authors: Izmi Dyas Syahlia , Yulaicho Mahmudalia Rosa , Nawangsari Ertien Rining
Published: October 2021

The Agricultural Development Strategic Command Program (Kostratani) emerged as the government's effort to realize national food sovereignty. Sidoarjo Regency, which has an area of 71,424.3 km2 and an area of 23,566 hectares of rice fields, with the agricultural sector being a leading commodity, seeks to realize the objectives of the program through the District Agricultural Extension Center (BPP), one of which is in Sukodono. The purpose of this study is to determine the extent of the implementation of the Strategic Agricultural Development Command Program (Kostratani) in Sukodono District, Sidoarjo Regency. This research uses descriptive qualitative research methods with data collection techniques through interviews with related parties and data observation. The theory used in this study is the theory of policy implementation from Merilee S.Grindle. The results of this study are expected to provide knowledge of public administration related to agriculture, especially the Strategic Agricultural Development Command Program (Kostratani). In addition, it is hoped that this research can help farmers to further increase agricultural potential and the urgency of agricultural progress in supporting the realization of national food sovereignty.
Pemaknaan Islam Moderat Sebagai Sebuah Terminologi
Authors: Sahputra Dedi
Published: October 2021

This article aims to find out the meaning of the term moderate Islam as a terminology. The problem is focused on reviewing the language and its history, as well as from the context of the political interests that lie behind it. In order to approach the problem, this article uses a reference to the theory of terminology. The data were collected through a literature review of various similar studies that have been conducted. Furthermore, the data obtained were analyzed qualitatively. This study concludes that there is a bias in understanding the terminology of moderate Islam which lies in equating the word "Islam" with the word "ummah", so that the term "ummatan wasatan" is then equated with "moderate Islam". This interpretation bias is strongly influenced by the global political context related to the emergence of the term terrorism and the concept of the global war on terrorism (GWOT) which was coined by the United States during the George W. Bush Junior administration.
Analisis Hasil Gambar Ilustrasi Berdasarkan Aspek Proporsi, Perspektif dan Pencahayaan
Authors: Apriliani Rizky , Zulkifli Zulkifli
Published: October 2021

This study aims to determine the students' ability to draw illustrations in applying the work of drawing illustrations in class VIII SMP Muhammadiyah 7 Medan based on proportions, perspectives and lighting. With the theme of the atmosphere of activities commemorating Indonesia's independence day. The population in this study were all students' works of class VIII SMP Muhamadiyah 7 Medan, namely all students' works and the sample was 21 students' works of class VIII-1 using the purposive sampling technique. This study uses a descriptive qualitative method to find out how the work of illustration images by class VIII students of SMP Muhammadiyah 7 Medan is viewed from the perspective of proportion, perspective and lighting. The findings of this study indicate that the overall ability of class VIII-1 students in drawing illustrations based on proportion, perspective and lighting has a good category with an average value (r) = 85.
Ornamen Flora Teknik Kolase pada Toples Makanan Berbahan Stiker Berdasarkan Prinsip-Prinsip Seni Rupa
Authors: Ilmi Rahmita , Azmi Azmi
Published: October 2021

This study aims to see the ability of students to apply decorative styles with the collage technique made from stickers in class VII SMP Negeri 1 Perbaungan based on the principles of fine arts, namely unity, balance, and rhythm. The theme used is flora with food jars as media. Based on the researchers 'initial observations, the students' decorative works using paint on paper media were still not optimal. As well as the lack of student knowledge in applying the principles of fine arts is a factor driving student work to be less than optimal. The population in this study was all class VII students of SMP Negeri 1 Perbaungan with 277 students. The sample was 21 students of class VII-1 (superior) using the purposive sampling technique. This study used the descriptive qualitative method. The findings of this study indicate that, in total, the application of the ornamental variety of class VII-1 collage techniques based on the principles of unity, balance, and rhythm has an average value of = 79.5 with a reasonably good category. In detail, the average value is based on the following three aspects: unity = 79.7 (good enough), balance = 79.5 (good enough), and rhythm = 79.3 (good enough) with performance indicators: unity, balance, and rhythm.
Pelatihan Pemanfaatan Mobile Aplikasi Edmodo Pada Guru Seni Budaya
Authors: Budiman Agus , Rohayani Heny , Nugraheni Trianti
Published: October 2021

The purpose of this study was to determine the results of online learning training for art teachers in Pandeglang-Banten through Edmodo Mobile-Application to be applied in art learning in schools. This qualitative study used a research sample of 40 training participants with a purposive sampling technique. The research data were obtained from the results of questionnaires and observations. The results showed that the mobile-application edomodo is one of the applications that can be accessed via smartphones or other technological devices such as laptops and computers, which can be used as a forum or means of art learning by both teachers and students through several features that can be used as access to learning media taught by students and teachers. The results of this training are able to improve the pedagogical ability and professionalism of teachers in implementing technology-based art learning. The conclusion of this study is that the skills of teachers in using technology in art learning in the industrial era 4.0 need to be improved as an effort to adapt to various technological and information developments that must be utilized in art education.
Analisis Yuridis Tindak Pidana Pencucian Uang (Studi Putusan No. 311/Pid.Sus/2018/Pn. Mdn)
Authors: Pratama Andika , Zulyadi Rizkan , Pinem Sri
Published: October 2021

The panel of judges adjudicating the money laundering case found the defendant guilty of the crime of money laundering from the narcotics crime, and therefore sentenced the defendant to 7 (seven) years imprisonment. Based on this, the formulation of the problems in this study: 1) How are the legal rules regarding money laundering in Indonesia, 2) How is law enforcement against the crime of money laundering in the Medan District Court, 3) What is the basis for the judge's consideration in imposing crimes against money laundering offenders in the Decision Number 311 / Pid.sus / 2018 / PN. Mdn. The research method used is descriptive method, while the data analysis technique used is descriptive qualitative. The results showed that the crime of money laundering is regulated in Law no. 8 of 2010 concerning the Prevention and Eradication of the Crime of Money Laundering (UU PP - TPPU). The threat of money laundering is regulated in Article 3, namely imprisonment for a maximum of 20 (twenty) years and a maximum fine of Rp. 10,000,000,000. The panel of judges at the District Court that adjudicates money laundering crimes acts decisively in imposing crimes, especially because the examination process usually receives public scrutiny, such as money laundering from narcotics and corruption crimes. The basis for the consideration that the panel of judges, the defendant has participated in the circulation of narcotics by receiving, transferring money as payment for narcotics, this is commonly done by the perpetrators of the Crime of Money Laundering to disguise or hide the origin of the proceeds of crime. However, the panel of judges had imposed a sentence that was too low on the defendant, namely 7 years in prison, far below the threat of money laundering in Article 3 of the TPPU Law where the defendant was found guilty, namely 20 years in prison.
Pergeseran Mata Pencaharian Petani
Authors: Hentihu Idrus , Umanailo M Chairul Basrun , Abd Radjak Darwin , Lionardo Andries
Published: October 2021

This paper aims to examine the problem of decreasing agricultural land in Namlea village which has become a new infrastructure development area so that it shifts the function of land out of the agricultural sector. The problem is focused on shifting land use which makes workers in the agricultural sector less and less which affects productivity. This study seeks to identify the impact of urbanization and the diversification actions taken by the community on their agricultural land as an effort to fulfill their daily needs. This study uses a qualitative approach and the number of informants to be interviewed is 15 people who are taken purposively. The research was conducted in Namlea Village, Buru Regency with informants including village officials, BPD members, representatives of community leaders, traditional leaders and religious leaders plus community representatives who are considered to have competencies related to the research objectives. This study uses observation data collection techniques and in-depth interviews. The analytical technique used in this research is qualitative data analysis following the concept given by Miles and Huberman and Spradley. This study concludes that the impact of land conversion results in the limitations of farmers in Namlea Village to access the jobs they have been getting to meet their daily needs and have to do other jobs of course with low pay, all of this is done solely to meet household needs.