bluuebunny/crossref_metadata_2025 huggingface dataset:
Unveiling tumor invasiveness: enhancing cancer diagnosis with phase-contrast microtomography for 3D virtual histology
Authors: Donato Sandro , Agostino Raffaele G. , Arana Peña Lucia M. , Arfelli Fulvia , Brombal Luca , Longo Renata , Martellani Fulvia , Romano Andrea , Rosano Ida , Saccomano Giulia , Tromba Giuliana , Bonazza Deborah
Published: May 2024

Malignant diseases are characterized by a critical trait known as invasiveness, where tumor cells tend to spread from the primary tissue layer into surrounding healthy tissues and distant organs. Presently, histopathology offers essential insights for diagnosing, classifying, predicting outcomes, and guiding patient-specific treatments. However, histology offers two-dimensional data from chosen cutting planes. Although 3D histological volumes can be generated through serial sectioning or whole slide imaging, this method is laborious, may introduce processing artefacts, and lacks isotropic spatial resolution. These limitations pose a considerable challenge to accurate diagnoses, particularly when dealing with micro-infiltrating carcinomas. These lesions, characterized by minute infiltrations, demand a three-dimensional representation for comprehensive visualization, essential for precise identification and assessment. Emerging X-ray-based virtual histology technology offers three-dimensional visualization of soft-tissue specimens, enabling virtual slicing in any direction or at any point. This approach can assist in guiding tissue sectioning for optimal representation of tumor cross sections during histological analysis. Micro-infiltrating carcinomas from the breast, cervix, and thyroid were imaged using X-ray phase-contrast microtomography (PhC-$$\mu$$
μ
CT) at the Elettra synchrotron facility in Trieste, Italy. Comparative assessment of histological and CT slices by pathologists revealed that PhC-$$\mu$$
μ
CT aids in classifying lesions by highlighting distinct tissue components and, notably, identifying tissue invasion. Reviewing a volume image allows pathologists to trace the entire lesion, identifying invasion sites that might be overlooked in individual or serial histological sections. Consequently, this proposed method could complement pathologists’ tools, potentially enhancing diagnoses by minimizing under-staging and reducing false negative results.
Quantile Effect of Economic Factors and Energy Consumption on Environmental Degradation in Vietnam
Authors: Xuan Hoang Thi , Hai Nguyen Chi , Hung Ngo Thai
Published: May 2024

This study aims to highlight the asymmetric impact of economic growth (GDP), trade openness (TO), energy consumption (EC), foreign direct investment (FDI), and financial development (FD) on carbon dioxide (CO2) emissions in Vietnam over the period 1990–2022, using quantile-on-quantile regression and Granger causality in quantiles techniques. Our mainstream findings indicate that the selected macroeconomic indicators have a strong positive effect on CO2 emissions in this country, and this effect is more pronounced in the lowest and highest quantiles of the respective variables. In addition, the results of Granger causality suggest a bidirectional causal relationship between the examined indicators. These findings suggest that fostering economic growth, promoting trade openness, managing energy consumption, encouraging foreign direct investment, and enhancing financial development can contribute to a sustainable environment in Vietnam.
Identify, Adapt, Persist
Authors: Lee Jarrett G.W. , Lee Bongshin , Choi Soyoung , Seo JooYoung , Choe Eun Kyoung
Published: May 2024

Personal health technologies (PHTs) often do not consider the accessibility needs of blind individuals, preventing access to their capabilities and data. However, despite the accessibility barriers, some blind individuals persistently use such systems and even express satisfaction with them. To obtain a deeper understanding of blind users' prolonged experiences in PHTs, we interviewed 11 individuals who continue to use such technologies, discussing and observing their past and current interactions with their systems. We report on usability issues blind users encounter and how they adapt to these situations, and theories for the persistent use of PHTs in the face of poor accessibility. We reflect on strategies to improve the accessibility and usability of PHTs for blind users, as well as ideas to aid the normalization of accessible features within these systems.
SmallMap: Low-cost Community Road Map Sensing with Uncertain Delivery Behavior
Authors: Hong Zhiqing , Wang Haotian , Ding Yi , Wang Guang , He Tian , Zhang Desheng
Published: May 2024

Accurate road networks play a crucial role in modern mobile applications such as navigation and last-mile delivery. Most existing studies primarily focus on generating road networks in open areas like main roads and avenues, but little attention has been given to the generation of community road networks in closed areas such as residential areas, which becomes more and more significant due to the growing demand for door-to-door services such as food delivery. This lack of research is primarily attributed to challenges related to sensing data availability and quality. In this paper, we design a novel framework called SmallMap that leverages ubiquitous multi-modal sensing data from last-mile delivery to automatically generate community road networks with low costs. Our SmallMap consists of two key modules: (1) a Trajectory of Interest Detection module enhanced by exploiting multi-modal sensing data collected from the delivery process; and (2) a Dual Spatio-temporal Generative Adversarial Network module that incorporates Trajectory of Interest by unsupervised road network adaptation to generate road networks automatically. To evaluate the effectiveness of SmallMap, we utilize a two-month dataset from one of the largest logistics companies in China. The extensive evaluation results demonstrate that our framework significantly outperforms state-of-the-art baselines, achieving a precision of 90.5%, a recall of 87.5%, and an F1-score of 88.9%, respectively. Moreover, we conduct three case studies in Beijing City for courier workload estimation, Estimated Time of Arrival (ETA) in last-mile delivery, and fine-grained order assignment.
Talk2Care: An LLM-based Voice Assistant for Communication between Healthcare Providers and Older Adults
Authors: Yang Ziqi , Xu Xuhai , Yao Bingsheng , Rogers Ethan , Zhang Shao , Intille Stephen , Shara Nawar , Gao Guodong Gordon , Wang Dakuo
Published: May 2024

Despite the plethora of telehealth applications to assist home-based older adults and healthcare providers, basic messaging and phone calls are still the most common communication methods, which suffer from limited availability, information loss, and process inefficiencies. One promising solution to facilitate patient-provider communication is to leverage large language models (LLMs) with their powerful natural conversation and summarization capability. However, there is a limited understanding of LLMs' role during the communication. We first conducted two interview studies with both older adults (N=10) and healthcare providers (N=9) to understand their needs and opportunities for LLMs in patient-provider asynchronous communication. Based on the insights, we built an LLM-powered communication system, Talk2Care, and designed interactive components for both groups: (1) For older adults, we leveraged the convenience and accessibility of voice assistants (VAs) and built an LLM-powered conversational interface for effective information collection. (2) For health providers, we built an LLM-based dashboard to summarize and present important health information based on older adults' conversations with the VA. We further conducted two user studies with older adults and providers to evaluate the usability of the system. The results showed that Talk2Care could facilitate the communication process, enrich the health information collected from older adults, and considerably save providers' efforts and time. We envision our work as an initial exploration of LLMs' capability in the intersection of healthcare and interpersonal communication.
Illumination-Aware Low-Light Image Enhancement with Transformer and Auto-Knee Curve
Authors: Pan Jinwang , Liu Xianming , Bai Yuanchao , Zhai Deming , Jiang Junjun , Zhao Debin
Published: May 2024

Images captured under low-light conditions suffer from several combined degradation factors, including low brightness, low contrast, noise, and color bias. Many learning-based techniques attempt to learn the low-to-clear mapping between low-light and normal-light images. However, they often fall short when applied to low-light images taken in wide-contrast scenes because uneven illumination brings illumination-varying noise and the enhanced images are easily over-saturated in highlight areas. In this article, we present a novel two-stage method to tackle the problem of uneven illumination distribution in low-light images. Under the assumption that noise varies with illumination, we design an illumination-aware transformer network for the first stage of image restoration. In this stage, we introduce the Illumination-aware Attention Block featured with Illumination-aware Multi-head Self-attention, which incorporates different scales of illumination features to guide the attention module, thereby enhancing the denoising and reconstruction capabilities of the restoration network. In the second stage, we innovatively introduce a cubic auto-knee curve transfer with a global parameter predictor to alleviate the over-exposure caused by uneven illumination. We also adopt a white balance correction module to address color bias issues at this stage. Extensive experiments on various benchmarks demonstrate the advantages of our method over state-of-the-art methods qualitatively and quantitatively.
Identification of Lipotoxicity‐Related Biomarkers in Diabetic Nephropathy Based on Bioinformatic Analysis
Authors: Nie Han , Yang Huan , Cheng Lidan , Yu Jianxin
Published: May 2024

Objective: This study is aimed at investigating diagnostic biomarkers associated with lipotoxicity and the molecular mechanisms underlying diabetic nephropathy (DN).

Methods: The GSE96804 dataset from the Gene Expression Omnibus (GEO) database was utilized to identify differentially expressed genes (DEGs) in DN patients. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were conducted using the DEGs. A protein–protein interaction (PPI) network was established to identify key genes linked to lipotoxicity in DN. Immune infiltration analysis was employed to identify immune cells with differential expression in DN and to assess the correlation between these immune cells and lipotoxicity‐related hub genes. The findings were validated using the external dataset GSE104954. ROC analysis was performed to assess the diagnostic performance of the hub genes. The Gene set enrichment analysis (GSEA) enrichment method was utilized to analyze the key genes associated with lipotoxicity as mentioned above.

Result: In this study, a total of 544 DEGs were identified. Among them, extracellular matrix (ECM), fatty acid metabolism, AGE‐RAGE, and PI3K‐Akt signaling pathways were significantly enriched. Combining the PPI network and lipotoxicity‐related genes (LRGS), LUM and ALB were identified as lipotoxicity‐related diagnostic biomarkers for DN. ROC analysis showed that the AUC values for LUM and ALB were 0.882 and 0.885, respectively. The AUC values for LUM and ALB validated in external datasets were 0.98 and 0.82, respectively. Immune infiltration analysis revealed significant changes in various immune cells during disease progression. Macrophages M2, mast cells activated, and neutrophils were significantly associated with all lipotoxicity‐related hub genes. These key genes were enriched in fatty acid metabolism and extracellular matrix‐related pathways.

Conclusion: The identified lipotoxicity‐related hub genes provide a deeper understanding of the development mechanisms of DN, potentially offering new theoretical foundations for the development of diagnostic biomarkers and therapeutic targets related to lipotoxicity in DN.
Undergraduate Nursing Students’ Experiences of Virtual Learning during the COVID‐19 Pandemic: A Qualitative Study
Authors: Asgari Tapeh Zahra , Darvishpour Azar
Published: May 2024

Background. With the emergence of the COVID‐19 pandemic, schools and universities were closed, and virtual education replaced face‐to‐face classes. This learning method was a new and different experience for nursing students. Perceiving their experiences could help improve the quality of medical education. Therefore, the present study aimed to describe nursing students’ experiences of virtual learning during the COVID‐19 pandemic. Materials and Methods. This study involved qualitative descriptive research that was conducted in 2022. The participants included 25 undergraduate nursing students studying at the School of Nursing and Midwifery in East Guilan in northern Iran who had experienced virtual learning due to the COVID‐19 pandemic. Purposeful sampling was applied until data saturation. Qualitative content analysis with a conventional approach was performed based on the model proposed by Graneheim and Lundman (2004). Coding was performed with MAXQDA 2007 software. Results. The data analysis led to the emergence of 110 primary codes and two main categories entitled “positive experiences” and “negative experiences.” The first main category was “positive experiences” (included 1 subcategory (benefits of virtual learning) with 3 subsubcategories (saving time, saving money, and increasing the possibility of daily planning)). The second main category was “negative experiences” (included 4 subcategories (reducing quality of education, physical effects, psychological effects, and different exams)). Conclusion. Nursing students had both positive and negative experiences with virtual learning during the COVID‐19 pandemic and were facing multiple educational challenges. The findings of this study could be considered by managers and relevant officials in educational planning to improve the quality of nursing education.
Supplemental Figures 1-10 from Transcriptomic Profiling of Plasma Extracellular Vesicles Enables Reliable Annotation of the Cancer-Specific Transcriptome and Molecular Subtype
Authors: Bahrambeigi Vahid , Lee Jaewon J. , Branchi Vittorio , Rajapakshe Kimal I. , Xu Zhichao , Kui Naishu , Henry Jason T. , Kun Wang , Stephens Bret M. , Dhebat Sarah , Hurd Mark W. , Sun Ryan , Yang Peng , Ruppin Eytan , Wang Wenyi , Kopetz Scott , Maitra Anirban , Guerrero Paola A.
Published: May 2024

Supplemental Figures 1-10 from Transcriptomic Profiling of Plasma Extracellular Vesicles Enables Reliable Annotation of the Cancer-Specific Transcriptome and Molecular Subtype
Figure S6 from Bile Acid Metabolism Mediates Cholesterol Homeostasis and Promotes Tumorigenesis in Clear Cell Renal Cell Carcinoma
Authors: Riscal Romain , Gardner Sarah M. , Coffey Nathan J. , Carens Madeleine , Mesaros Clementina , Xu Jimmy P. , Xue Yizheng , Davis Leah , Demczyszyn Sara , Vogt Austin , Olia Adam , Finan Jennifer M. , Godfrey Jason , Schultz David C. , Blair Ian A. , Keith Brian , Marmorstein Ronen , Skuli Nicolas , Simon M. Celeste
Published: May 2024

Figure S6
Figure S4 from Bile Acid Metabolism Mediates Cholesterol Homeostasis and Promotes Tumorigenesis in Clear Cell Renal Cell Carcinoma
Authors: Riscal Romain , Gardner Sarah M. , Coffey Nathan J. , Carens Madeleine , Mesaros Clementina , Xu Jimmy P. , Xue Yizheng , Davis Leah , Demczyszyn Sara , Vogt Austin , Olia Adam , Finan Jennifer M. , Godfrey Jason , Schultz David C. , Blair Ian A. , Keith Brian , Marmorstein Ronen , Skuli Nicolas , Simon M. Celeste
Published: May 2024

Figure S4
Figure S2 from Bile Acid Metabolism Mediates Cholesterol Homeostasis and Promotes Tumorigenesis in Clear Cell Renal Cell Carcinoma
Authors: Riscal Romain , Gardner Sarah M. , Coffey Nathan J. , Carens Madeleine , Mesaros Clementina , Xu Jimmy P. , Xue Yizheng , Davis Leah , Demczyszyn Sara , Vogt Austin , Olia Adam , Finan Jennifer M. , Godfrey Jason , Schultz David C. , Blair Ian A. , Keith Brian , Marmorstein Ronen , Skuli Nicolas , Simon M. Celeste
Published: May 2024

Figure S2
Figure S1 from Bile Acid Metabolism Mediates Cholesterol Homeostasis and Promotes Tumorigenesis in Clear Cell Renal Cell Carcinoma
Authors: Riscal Romain , Gardner Sarah M. , Coffey Nathan J. , Carens Madeleine , Mesaros Clementina , Xu Jimmy P. , Xue Yizheng , Davis Leah , Demczyszyn Sara , Vogt Austin , Olia Adam , Finan Jennifer M. , Godfrey Jason , Schultz David C. , Blair Ian A. , Keith Brian , Marmorstein Ronen , Skuli Nicolas , Simon M. Celeste
Published: May 2024

Figure S1
Table S1 from PABPC1L Induces IDO1 to Promote Tryptophan Metabolism and Immune Suppression in Renal Cell Carcinoma
Authors: Shu Guannan , Chen Minyu , Liao Wuyuan , Fu Liangmin , Lin Mingjie , Gui Chengpeng , Cen Junjie , Lu Jun , Chen Zhenhua , Wei Jinhuan , Chen Wei , Wang Yinghan , Zhu Jiangquan , Zhao Tianxin , Liu Xiaonan , Jing Jiajia , Liu Guo-chang , Pan Yihui , Luo Junhang , Zhang Jiaxing
Published: May 2024

Table S1
Figure S3 from DNA of Neutrophil Extracellular Traps Binds TMCO6 to Impair CD8+ T-cell Immunity in Hepatocellular Carcinoma
Authors: Song Mengjia , Zhang Chaoqi , Cheng Shaoyan , Ouyang Dijun , Ping Yu , Yang Jieying , Zhang YaoJun , Tang Yan , Chen Hao , Wang Qi-jing , Li Yong-qiang , He Jia , Xiang Tong , Zhang Yizhuo , Xia Jian-Chuan
Published: May 2024

The representative dotplots used for gating strategies of flow staining for NK, CD4+, CD8+ IFN-γ+, and CD8+ granzyme B+ cells in in-vivo experiments.
Supplementary Data 2 from PABPC1L Induces IDO1 to Promote Tryptophan Metabolism and Immune Suppression in Renal Cell Carcinoma
Authors: Shu Guannan , Chen Minyu , Liao Wuyuan , Fu Liangmin , Lin Mingjie , Gui Chengpeng , Cen Junjie , Lu Jun , Chen Zhenhua , Wei Jinhuan , Chen Wei , Wang Yinghan , Zhu Jiangquan , Zhao Tianxin , Liu Xiaonan , Jing Jiajia , Liu Guo-chang , Pan Yihui , Luo Junhang , Zhang Jiaxing
Published: May 2024

Supplementary Data 2
Figure S14 from DNA of Neutrophil Extracellular Traps Binds TMCO6 to Impair CD8+ T-cell Immunity in Hepatocellular Carcinoma
Authors: Song Mengjia , Zhang Chaoqi , Cheng Shaoyan , Ouyang Dijun , Ping Yu , Yang Jieying , Zhang YaoJun , Tang Yan , Chen Hao , Wang Qi-jing , Li Yong-qiang , He Jia , Xiang Tong , Zhang Yizhuo , Xia Jian-Chuan
Published: May 2024

The expression of TMCO6 and its relationship with CD8+ T cell-immunity in HB.
Figure S13 from DNA of Neutrophil Extracellular Traps Binds TMCO6 to Impair CD8+ T-cell Immunity in Hepatocellular Carcinoma
Authors: Song Mengjia , Zhang Chaoqi , Cheng Shaoyan , Ouyang Dijun , Ping Yu , Yang Jieying , Zhang YaoJun , Tang Yan , Chen Hao , Wang Qi-jing , Li Yong-qiang , He Jia , Xiang Tong , Zhang Yizhuo , Xia Jian-Chuan
Published: May 2024

The expression and prognosis value of NETs in HB.
Supplementary Data from Integrin αvβ3 Upregulation in Response to Nutrient Stress Promotes Lung Cancer Cell Metabolic Plasticity
Authors: Nam Arin , Jain Shashi , Wu Chengsheng , Campos Alejandro , Shepard Ryan M. , Yu Ziqi , Reddy Joshua P. , Von Schalscha Tami , Weis Sara M. , Onaitis Mark , Wettersten Hiromi I. , Cheresh David A.
Published: May 2024

Supplementary files
Figure S1 from Lipid-Encapsulated mRNAs Encoding Complex Fusion Proteins Potentiate Antitumor Immune Responses
Authors: Shuptrine Casey W. , Chen Yuhui , Miriyala Jayalakshmi , Lenz Karen , Moffett Danielle , Nguyen Thuy-Ai , Michaux Jenn , Campbell Kristen , Smith Connor , Morra Marc , Rivera-Molina Yisel , Murr Noah , Cooper Sarah , McGuire Ashlyn , Makani Vishruti , Oien Nathan , Zugates Jeffery T. , de Silva Suresh , Schreiber Taylor H. , de Picciotto Seymour , Fromm George
Published: May 2024

Supplemental Figure 1
Supplementary Table S4 from ATG-101 Is a Tetravalent PD-L1×4-1BB Bispecific Antibody That Stimulates Antitumor Immunity through PD-L1 Blockade and PD-L1–Directed 4-1BB Activation
Authors: Yuwen Hui , Wang Huajing , Li Tengteng , Ren Yijing , Zhang Yun-kai , Chen Peng , Sun Ao , Bian Gang , Li Bohua , Flowers David , Presler Marc , Subramanian Kalyanasundaram , Xue Jia , Wang Jingjing , Lynch Kevin , Mei Jay , He Xiaowen , Shan Bo , Hou Bing
Published: May 2024

Genetic marker or signature genes for cell subtypes described in scRNAseq analysis
Supplementary Table S3 from ATG-101 Is a Tetravalent PD-L1×4-1BB Bispecific Antibody That Stimulates Antitumor Immunity through PD-L1 Blockade and PD-L1–Directed 4-1BB Activation
Authors: Yuwen Hui , Wang Huajing , Li Tengteng , Ren Yijing , Zhang Yun-kai , Chen Peng , Sun Ao , Bian Gang , Li Bohua , Flowers David , Presler Marc , Subramanian Kalyanasundaram , Xue Jia , Wang Jingjing , Lynch Kevin , Mei Jay , He Xiaowen , Shan Bo , Hou Bing
Published: May 2024

ScRNAseq data reavealed the cell types and differential expressed genes of TILs from IgG and ATG-101 groups
Supplementary Data from ATG-101 Is a Tetravalent PD-L1×4-1BB Bispecific Antibody That Stimulates Antitumor Immunity through PD-L1 Blockade and PD-L1–Directed 4-1BB Activation
Authors: Yuwen Hui , Wang Huajing , Li Tengteng , Ren Yijing , Zhang Yun-kai , Chen Peng , Sun Ao , Bian Gang , Li Bohua , Flowers David , Presler Marc , Subramanian Kalyanasundaram , Xue Jia , Wang Jingjing , Lynch Kevin , Mei Jay , He Xiaowen , Shan Bo , Hou Bing
Published: May 2024

Supplementary Methods, Supplementary Figures and Supplementary Table S1-2
Data from Bile Acid Metabolism Mediates Cholesterol Homeostasis and Promotes Tumorigenesis in Clear Cell Renal Cell Carcinoma
Authors: Riscal Romain , Gardner Sarah M. , Coffey Nathan J. , Carens Madeleine , Mesaros Clementina , Xu Jimmy P. , Xue Yizheng , Davis Leah , Demczyszyn Sara , Vogt Austin , Olia Adam , Finan Jennifer M. , Godfrey Jason , Schultz David C. , Blair Ian A. , Keith Brian , Marmorstein Ronen , Skuli Nicolas , Simon M. Celeste
Published: May 2024

Abstract
Clear cell renal cell carcinoma (ccRCC) incidence has risen steadily over the last decade. Elevated lipid uptake and storage is required for ccRCC cell viability. As stored cholesterol is the most abundant component in ccRCC intracellular lipid droplets, it may also play an important role in ccRCC cellular homeostasis. In support of this hypothesis, ccRCC cells acquire exogenous cholesterol through the high-density lipoprotein receptor SCARB1, inhibition or suppression of which induces apoptosis. Here, we showed that elevated expression of 3 beta-hydroxy steroid dehydrogenase type 7 (HSD3B7), which metabolizes cholesterol-derived oxysterols in the bile acid biosynthetic pathway, is also essential for ccRCC cell survival. Development of an HSD3B7 enzymatic assay and screening for small-molecule inhibitors uncovered the compound celastrol as a potent HSD3B7 inhibitor with low micromolar activity. Repressing HSD3B7 expression genetically or treating ccRCC cells with celastrol resulted in toxic oxysterol accumulation, impaired proliferation, and increased apoptosis in vitro and in vivo. These data demonstrate that bile acid synthesis regulates cholesterol homeostasis in ccRCC and identifies HSD3B7 as a plausible therapeutic target.
Significance:
The bile acid biosynthetic enzyme HSD3B7 is essential for ccRCC cell survival and can be targeted to induce accumulation of cholesterol-derived oxysterols and apoptotic cell death.
Data from PABPC1L Induces IDO1 to Promote Tryptophan Metabolism and Immune Suppression in Renal Cell Carcinoma
Authors: Shu Guannan , Chen Minyu , Liao Wuyuan , Fu Liangmin , Lin Mingjie , Gui Chengpeng , Cen Junjie , Lu Jun , Chen Zhenhua , Wei Jinhuan , Chen Wei , Wang Yinghan , Zhu Jiangquan , Zhao Tianxin , Liu Xiaonan , Jing Jiajia , Liu Guo-chang , Pan Yihui , Luo Junhang , Zhang Jiaxing
Published: May 2024

Abstract
The tumor microenvironment (TME) in renal cell carcinomas (RCC) is marked by substantial immunosuppression and immune resistance despite having extensive T-cell infiltration. Elucidation of the mechanisms underlying immune evasion could help identify therapeutic strategies to boost the efficacy of immune checkpoint blockade (ICB) in RCC. This study uncovered a mechanism wherein the polyadenylate-binding protein PABPC1L modulates indoleamine 2,3-dioxygenase 1 (IDO1), a prospective target for immunotherapy. PABPC1L was markedly upregulated in RCC, and high PABPC1L expression correlated with unfavorable prognosis and resistance to ICB. PABPC1L bolstered tryptophan metabolism by upregulating IDO1, inducing T-cell dysfunction and Treg infiltration. PABPC1L enhanced the stability of JAK2 mRNA, leading to increased JAK2-STAT1 signaling that induced IDO1 expression. Additionally, PABPC1L-induced activation of the JAK2-STAT1 axis created a positive feedback loop to promote PABPC1L transcription. Conversely, loss of PABPC1L diminished IDO1 expression, mitigated cytotoxic T-cell suppression, and enhanced responsiveness to anti-PD-1 therapy in patient-derived xenograft models. These findings reveal the crucial role of PABPC1L in facilitating immune evasion in RCC and indicate that inhibiting PABPC1L could be a potential immunotherapeutic approach in combination with ICB to improve patient outcomes.
Significance:
PABPC1L functions as a key factor in renal cell carcinoma immune evasion, enhancing IDO1 and impeding T-cell function, and represents a potential target to enhance the efficacy of immune checkpoint blockade therapy.
Data from Integrin αvβ3 Upregulation in Response to Nutrient Stress Promotes Lung Cancer Cell Metabolic Plasticity
Authors: Nam Arin , Jain Shashi , Wu Chengsheng , Campos Alejandro , Shepard Ryan M. , Yu Ziqi , Reddy Joshua P. , Von Schalscha Tami , Weis Sara M. , Onaitis Mark , Wettersten Hiromi I. , Cheresh David A.
Published: May 2024

Abstract
Cancer stem/tumor-initiating cells display stress tolerance and metabolic flexibility to survive in a harsh environment with limited nutrient and oxygen availability. The molecular mechanisms underlying this phenomenon could provide targets to prevent metabolic adaptation and halt cancer progression. Here, we showed in cultured cells and live human surgical biopsies of non–small cell lung cancer that nutrient stress drives the expression of the epithelial cancer stem cell marker integrin αvβ3 via upregulation of the β3 subunit, resulting in a metabolic reprogramming cascade that allows tumor cells to thrive despite a nutrient-limiting environment. Although nutrient deprivation is known to promote acute, yet transient, activation of the stress sensor AMP-activated protein kinase (AMPK), stress-induced αvβ3 expression via Src activation unexpectedly led to secondary and sustained AMPK activation. This resulted in the nuclear localization of peroxisome proliferator-activated receptor-gamma coactivator 1α (PGC1α) and upregulation of glutamine metabolism, the tricarboxylic acid cycle, and oxidative phosphorylation. Pharmacological or genetic targeting of this axis prevented lung cancer cells from evading the effects of nutrient stress, thereby blocking tumor initiation in mice following orthotopic implantation of lung cancer cells. These findings reveal a molecular pathway driven by nutrient stress that results in cancer stem cell reprogramming to promote metabolic flexibility and tumor initiation.
Significance:
Upregulation of integrin αvβ3, a cancer stem cell marker, in response to nutrient stress activates sustained AMPK/PGC1α signaling that induces metabolic reprogramming in lung cancer cells to support their survival.

See related commentary by Rainero, p. 1543
Suppl Table S9 from Targeting CCL2/CCR2 Signaling Overcomes MEK Inhibitor Resistance in Acute Myeloid Leukemia
Authors: Modak Rucha V. , de Oliveira Rebola Katia G. , McClatchy John , Mohammadhosseini Mona , Damnernsawad Alisa , Kurtz Stephen E. , Eide Christopher A. , Wu Guanming , Laderas Ted , Nechiporuk Tamilla , Gritsenko Marina A. , Hansen Joshua R. , Hutchinson Chelsea , Gosline Sara J.C. , Piehowski Paul , Bottomly Daniel , Short Nicholas , Rodland Karin , McWeeney Shannon K. , Tyner Jeffrey W. , Agarwal Anupriya
Published: May 2024

CRISPR data from resistant cells
Suppl Table S5 from Targeting CCL2/CCR2 Signaling Overcomes MEK Inhibitor Resistance in Acute Myeloid Leukemia
Authors: Modak Rucha V. , de Oliveira Rebola Katia G. , McClatchy John , Mohammadhosseini Mona , Damnernsawad Alisa , Kurtz Stephen E. , Eide Christopher A. , Wu Guanming , Laderas Ted , Nechiporuk Tamilla , Gritsenko Marina A. , Hansen Joshua R. , Hutchinson Chelsea , Gosline Sara J.C. , Piehowski Paul , Bottomly Daniel , Short Nicholas , Rodland Karin , McWeeney Shannon K. , Tyner Jeffrey W. , Agarwal Anupriya
Published: May 2024

AML feature annotations
Supplementary Tables 1-4 from Xevinapant Combined with Pembrolizumab in Patients with Advanced, Pretreated, Colorectal and Pancreatic Cancer: Results of the Phase Ib/II CATRIPCA Trial
Authors: Voisin Allison , Terret Catherine , Schiffler Camille , Bidaux Anne-Sophie , Vanacker Hélène , Perrin-Niquet Marlène , Barbery Maud , Vinceneux Armelle , Eberst Lauriane , Stéphan Pierre , Garin Gwenaële , Spaggiari Dany , Pérol David , Grinberg-Bleyer Yenkel , Cassier Philippe A.
Published: May 2024

RRID compliant
Supplementary Figure 1-3 from Xevinapant Combined with Pembrolizumab in Patients with Advanced, Pretreated, Colorectal and Pancreatic Cancer: Results of the Phase Ib/II CATRIPCA Trial
Authors: Voisin Allison , Terret Catherine , Schiffler Camille , Bidaux Anne-Sophie , Vanacker Hélène , Perrin-Niquet Marlène , Barbery Maud , Vinceneux Armelle , Eberst Lauriane , Stéphan Pierre , Garin Gwenaële , Spaggiari Dany , Pérol David , Grinberg-Bleyer Yenkel , Cassier Philippe A.
Published: May 2024

Supplemetary figures S1, S2 and S3
Suppl Table 5 from Xevinapant Combined with Pembrolizumab in Patients with Advanced, Pretreated, Colorectal and Pancreatic Cancer: Results of the Phase Ib/II CATRIPCA Trial
Authors: Voisin Allison , Terret Catherine , Schiffler Camille , Bidaux Anne-Sophie , Vanacker Hélène , Perrin-Niquet Marlène , Barbery Maud , Vinceneux Armelle , Eberst Lauriane , Stéphan Pierre , Garin Gwenaële , Spaggiari Dany , Pérol David , Grinberg-Bleyer Yenkel , Cassier Philippe A.
Published: May 2024

Representativeness
Supplementary Table S2 from Developing Novel Genomic Risk Stratification Models in Soft Tissue and Uterine Leiomyosarcoma
Authors: Dermawan Josephine K. , Chiang Sarah , Singer Samuel , Jadeja Bhumika , Hensley Martee L. , Tap William D. , Movva Sujana , Maki Robert G. , Antonescu Cristina R.
Published: May 2024

Supplementary Table S2. Clinicopathologic summary of uterine leiomyosarcoma (ULMS)
Supplemental Table 1 from Molecular Profiling and the Impact of Treatment on Outcomes in Adenoid Cystic Carcinoma Type I and II
Authors: Hanna Glenn J. , Grover Punita , Elliott Andrew , McGrath Julie , Xiu Joanne , Sukari Ammar , Johnson Jennifer M. , Wise-Draper Trisha
Published: May 2024

Supplemental Table 1. Overall survival stratified by MYC and TP63 expression patterns and adenoid cystic carcinoma (ACC)-type I and II phenotyping.
Supplementary Figure S2 from Tumor-Infiltrating Lymphocytes Refine Outcomes in Triple-Negative Breast Cancer Treated with Anthracycline-Free Neoadjuvant Chemotherapy
Authors: Martín Miguel , Yoder Rachel , Salgado Roberto , del Monte-Millán María , Álvarez Enrique L. , Echavarría Isabel , Staley Joshua M. , O'Dea Anne P. , Nye Lauren E. , Stecklein Shane R. , Bueno Coralia , Jerez Yolanda , Cebollero María , Bueno Oscar , García Saenz José Ángel , Moreno Fernando , Bohn Uriel , Gómez Henry , Massarrah Tatiana , Khan Qamar J. , Godwin Andrew K. , López-Tarruella Sara , Sharma Priyanka
Published: May 2024

Pathologic response categories
Supplementary Figure S1 from Targeting SMAD3 Improves Response to Oxaliplatin in Esophageal Adenocarcinoma Models by Impeding DNA Repair
Authors: Ballout Farah , Lu Heng , Bhat Nadeem , Chen Lei , Peng Dunfa , Chen Zheng , Chen Steven , Sun Xiaodian , Giordano Silvia , Corso Simona , Zaika Alexander , McDonald Oliver , Livingstone Alan S. , El-Rifai Wael
Published: May 2024

Supplementary Figure 1. SMAD3 knockdown with two different pools of siRNA induces DNA damage in OE33 cells
Supplementary Table S3 from Response Rate and Molecular Correlates to Encorafenib and Binimetinib in BRAF-V600E Mutant High-Grade Glioma
Authors: Schreck Karisa C. , Strowd Roy E. , Nabors Louis B. , Ellingson Benjamin M. , Chang Michael , Tan Sze K. , Abdullaev Zied , Turakulov Rust , Aldape Kenneth , Danda Neeraja , Desideri Serena , Fisher Joy , Iacoboni Michaella , Surakus Trisha , Rudek Michelle A. , Bettegowda Chetan , Grossman Stuart A. , Ye Xiaobu
Published: May 2024

Supplementary Table S3: Adverse events.
Supplementary Figure S1 from The Irreversible FGFR Inhibitor KIN-3248 Overcomes FGFR2 Kinase Domain Mutations
Authors: Balasooriya Eranga R. , Wu Qibiao , Ellis Haley , Zhen Yuanli , Norden Bryanna L. , Corcoran Ryan B. , Mohan Adithi , Martin Eric , Franovic Aleksandra , Tyhonas John , Lardy Matthew , Grandinetti Kathryn B. , Pelham Robert , Soroceanu Liliana , Silveira Vanessa S. , Bardeesy Nabeel
Published: May 2024

Supplementary Figure S1. KIN-3248 activity against C492F mutation
Supplementary Figure S2 from FDA Approval Summary: Enfortumab Vedotin plus Pembrolizumab for Cisplatin-Ineligible Locally Advanced or Metastatic Urothelial Carcinoma
Authors: Maguire William F. , Lee Daniel , Weinstock Chana , Gao Xin , Bulik Catharine C. , Agrawal Sundeep , Chang Elaine , Hamed Salaheldin S. , Bloomquist Erik W. , Tang Shenghui , Pazdur Richard , Kluetz Paul G. , Amiri-Kordestani Laleh , Suzman Daniel L.
Published: May 2024

Figure S2 is a schematic diagram of key datasets supporting the FDA’s safety review for accelerated approval of enfortumab vedotin plus pembrolizumab for cisplatin-ineligible patients with locally advanced or metastatic urothelial cancer
Supplemental Table 5 from A Phase 0/I Pharmacokinetic and Pharmacodynamics and Safety and Tolerability Study of Letrozole in Combination with Standard Therapy in Recurrent High-Grade Gliomas
Authors: Desai Pankaj B. , Karve Aniruddha S. , Zawit Misam , Arora Priyanka , Dave Nimita , Awosika Joy , Li Ningjing , Fuhrman Bethany , Medvedovic Mario , Sallans Larry , Kendler Ady , DasGupta Biplab , Plas David , Curry Richard , Zuccarello Mario , Chaudhary Rekha , Sengupta Soma , Wise-Draper Trisha M.
Published: May 2024

Supplemental Table 5: List of differentially expressed genes
Supplemental Table 1 from A Phase 0/I Pharmacokinetic and Pharmacodynamics and Safety and Tolerability Study of Letrozole in Combination with Standard Therapy in Recurrent High-Grade Gliomas
Authors: Desai Pankaj B. , Karve Aniruddha S. , Zawit Misam , Arora Priyanka , Dave Nimita , Awosika Joy , Li Ningjing , Fuhrman Bethany , Medvedovic Mario , Sallans Larry , Kendler Ady , DasGupta Biplab , Plas David , Curry Richard , Zuccarello Mario , Chaudhary Rekha , Sengupta Soma , Wise-Draper Trisha M.
Published: May 2024

Supplemental Table 1: Cohort Doses
Supplemental Figure 1 from A Phase 0/I Pharmacokinetic and Pharmacodynamics and Safety and Tolerability Study of Letrozole in Combination with Standard Therapy in Recurrent High-Grade Gliomas
Authors: Desai Pankaj B. , Karve Aniruddha S. , Zawit Misam , Arora Priyanka , Dave Nimita , Awosika Joy , Li Ningjing , Fuhrman Bethany , Medvedovic Mario , Sallans Larry , Kendler Ady , DasGupta Biplab , Plas David , Curry Richard , Zuccarello Mario , Chaudhary Rekha , Sengupta Soma , Wise-Draper Trisha M.
Published: May 2024

Supplemental Figure 1: Consort Diagram
Supplementary Figure S9 from A Phase II Open-Label Randomized Clinical Trial of Preoperative Durvalumab or Durvalumab plus Tremelimumab in Resectable Head and Neck Squamous Cell Carcinoma
Authors: Kim Chang Gon , Hong Min Hee , Kim Dahee , Lee Brian Hyohyoung , Kim Hyunwook , Ock Chan-Young , Kelly Geoffrey , Bang Yoon Ji , Kim Gamin , Lee Jung Eun , Kim Chaeyeon , Kim Se-Heon , Hong Hyun Jun , Park Young Min , Sim Nam Suk , Park Heejung , Park Jin Woo , Lee Chang Geol , Kim Kyung Hwan , Park Goeun , Jung Inkyung , Han Dawoon , Kim Jong Hoon , Cha Junha , Lee Insuk , Kang Mingu , Song Heon , Oum Chiyoon , Kim Seulki , Kim Sukjun , Lim Yoojoo , Kim-Schulze Seunghee , Merad Miriam , Yoon Sun Och , Kim Hyun Je , Koh Yoon Woo , Kim Hye Ryun
Published: May 2024

Enumerization of tumor-infiltrating T cells by immunohistochemostry stain.
Supplementary Table S3 from First-in-Human Study of the Ataxia Telangiectasia and Rad3-Related (ATR) Inhibitor Tuvusertib (M1774) as Monotherapy in Patients with Solid Tumors
Authors: Yap Timothy A. , Tolcher Anthony W. , Plummer Ruth , Mukker Jatinder Kaur , Enderlin Marta , Hicking Christine , Grombacher Thomas , Locatelli Giuseppe , Szucs Zoltan , Gounaris Ioannis , de Bono Johann S.
Published: May 2024

Table S3. Grade ≥3 clinical laboratory anomalies by Worst On-Treatment NCI-CTCAE V5.0 Toxicity Grade (FAS/SAF Analysis Set)
Supplementary Table S2 from First-in-Human Study of the Ataxia Telangiectasia and Rad3-Related (ATR) Inhibitor Tuvusertib (M1774) as Monotherapy in Patients with Solid Tumors
Authors: Yap Timothy A. , Tolcher Anthony W. , Plummer Ruth , Mukker Jatinder Kaur , Enderlin Marta , Hicking Christine , Grombacher Thomas , Locatelli Giuseppe , Szucs Zoltan , Gounaris Ioannis , de Bono Johann S.
Published: May 2024

Table S2. Dose-limiting toxicities as per the SMC (DLT analysis set).
Supplementary Methods S1 from First-in-Human Study of the Ataxia Telangiectasia and Rad3-Related (ATR) Inhibitor Tuvusertib (M1774) as Monotherapy in Patients with Solid Tumors
Authors: Yap Timothy A. , Tolcher Anthony W. , Plummer Ruth , Mukker Jatinder Kaur , Enderlin Marta , Hicking Christine , Grombacher Thomas , Locatelli Giuseppe , Szucs Zoltan , Gounaris Ioannis , de Bono Johann S.
Published: May 2024

Supplementary Methods
Supplementary Figure S6 from A Phase II Open-Label Randomized Clinical Trial of Preoperative Durvalumab or Durvalumab plus Tremelimumab in Resectable Head and Neck Squamous Cell Carcinoma
Authors: Kim Chang Gon , Hong Min Hee , Kim Dahee , Lee Brian Hyohyoung , Kim Hyunwook , Ock Chan-Young , Kelly Geoffrey , Bang Yoon Ji , Kim Gamin , Lee Jung Eun , Kim Chaeyeon , Kim Se-Heon , Hong Hyun Jun , Park Young Min , Sim Nam Suk , Park Heejung , Park Jin Woo , Lee Chang Geol , Kim Kyung Hwan , Park Goeun , Jung Inkyung , Han Dawoon , Kim Jong Hoon , Cha Junha , Lee Insuk , Kang Mingu , Song Heon , Oum Chiyoon , Kim Seulki , Kim Sukjun , Lim Yoojoo , Kim-Schulze Seunghee , Merad Miriam , Yoon Sun Och , Kim Hyun Je , Koh Yoon Woo , Kim Hye Ryun
Published: May 2024

Comparison between pathologic response, radiologic response, and time of neoadjuvant period.
Supplementary Figure S4 from A Phase II Open-Label Randomized Clinical Trial of Preoperative Durvalumab or Durvalumab plus Tremelimumab in Resectable Head and Neck Squamous Cell Carcinoma
Authors: Kim Chang Gon , Hong Min Hee , Kim Dahee , Lee Brian Hyohyoung , Kim Hyunwook , Ock Chan-Young , Kelly Geoffrey , Bang Yoon Ji , Kim Gamin , Lee Jung Eun , Kim Chaeyeon , Kim Se-Heon , Hong Hyun Jun , Park Young Min , Sim Nam Suk , Park Heejung , Park Jin Woo , Lee Chang Geol , Kim Kyung Hwan , Park Goeun , Jung Inkyung , Han Dawoon , Kim Jong Hoon , Cha Junha , Lee Insuk , Kang Mingu , Song Heon , Oum Chiyoon , Kim Seulki , Kim Sukjun , Lim Yoojoo , Kim-Schulze Seunghee , Merad Miriam , Yoon Sun Och , Kim Hyun Je , Koh Yoon Woo , Kim Hye Ryun
Published: May 2024

Tumor regression, necrosis and residual viable tumor in response to the treatment administered.
Supplementary Table S9 from Biomarkers of Efficacy and Safety of the Academic BCMA-CART ARI0002h for the Treatment of Refractory Multiple Myeloma
Authors: Oliver-Caldes Aina , Español-Rego Marta , Zabaleta Aintzane , González-Calle Verónica , Navarro-Velázquez Sergio , Inogés Susana , de Cerio Ascensión López-Díaz , Cabañas Valentín , López-Muñoz Nieves , Rodríguez-Otero Paula , Reguera Juan Luis , Moreno David F. , Martínez-Cibrian Nuria , López-Corral Lucía , Pérez-Amill Lorena , Martin-Antonio Beatriz , Rosiñol Laura , Cid Joan , Tovar Natalia , Sáez-Peñataro Joaquín , López-Parra Miriam , Olesti Eulalia , Guillén Elena , Varea Sara , Rodríguez-Lobato Luis Gerardo , Battram Anthony M. , González Marta Sonia , Sánchez-Salinas Andrés , González-Navarro Azucena , Ortiz-Maldonado Valentín , Delgado Julio , Prósper Felipe , Juan Manel , Martínez-López Joaquín , Moraleda José M. , Mateos Maria Victoria , Urbano-Ispizua Álvaro , Paiva Bruno , Pascal Mariona , Fernández de Larrea Carlos
Published: May 2024

Table 9. Measurable residual disease results at different timepoints.
Supplementary Table S4 from Biomarkers of Efficacy and Safety of the Academic BCMA-CART ARI0002h for the Treatment of Refractory Multiple Myeloma
Authors: Oliver-Caldes Aina , Español-Rego Marta , Zabaleta Aintzane , González-Calle Verónica , Navarro-Velázquez Sergio , Inogés Susana , de Cerio Ascensión López-Díaz , Cabañas Valentín , López-Muñoz Nieves , Rodríguez-Otero Paula , Reguera Juan Luis , Moreno David F. , Martínez-Cibrian Nuria , López-Corral Lucía , Pérez-Amill Lorena , Martin-Antonio Beatriz , Rosiñol Laura , Cid Joan , Tovar Natalia , Sáez-Peñataro Joaquín , López-Parra Miriam , Olesti Eulalia , Guillén Elena , Varea Sara , Rodríguez-Lobato Luis Gerardo , Battram Anthony M. , González Marta Sonia , Sánchez-Salinas Andrés , González-Navarro Azucena , Ortiz-Maldonado Valentín , Delgado Julio , Prósper Felipe , Juan Manel , Martínez-López Joaquín , Moraleda José M. , Mateos Maria Victoria , Urbano-Ispizua Álvaro , Paiva Bruno , Pascal Mariona , Fernández de Larrea Carlos
Published: May 2024

Table 4. Cox regression analysis of the impact of the expression of exhaustion markers in progression-free (PFS) and overall survival (OS).
Supplementary Table S10 from Biomarkers of Efficacy and Safety of the Academic BCMA-CART ARI0002h for the Treatment of Refractory Multiple Myeloma
Authors: Oliver-Caldes Aina , Español-Rego Marta , Zabaleta Aintzane , González-Calle Verónica , Navarro-Velázquez Sergio , Inogés Susana , de Cerio Ascensión López-Díaz , Cabañas Valentín , López-Muñoz Nieves , Rodríguez-Otero Paula , Reguera Juan Luis , Moreno David F. , Martínez-Cibrian Nuria , López-Corral Lucía , Pérez-Amill Lorena , Martin-Antonio Beatriz , Rosiñol Laura , Cid Joan , Tovar Natalia , Sáez-Peñataro Joaquín , López-Parra Miriam , Olesti Eulalia , Guillén Elena , Varea Sara , Rodríguez-Lobato Luis Gerardo , Battram Anthony M. , González Marta Sonia , Sánchez-Salinas Andrés , González-Navarro Azucena , Ortiz-Maldonado Valentín , Delgado Julio , Prósper Felipe , Juan Manel , Martínez-López Joaquín , Moraleda José M. , Mateos Maria Victoria , Urbano-Ispizua Álvaro , Paiva Bruno , Pascal Mariona , Fernández de Larrea Carlos
Published: May 2024

Table 10. Multivariate analysis of the impact in progression-free survival of clinical variables at baseline.
Supplementary Methods S1 from Biomarkers of Efficacy and Safety of the Academic BCMA-CART ARI0002h for the Treatment of Refractory Multiple Myeloma
Authors: Oliver-Caldes Aina , Español-Rego Marta , Zabaleta Aintzane , González-Calle Verónica , Navarro-Velázquez Sergio , Inogés Susana , de Cerio Ascensión López-Díaz , Cabañas Valentín , López-Muñoz Nieves , Rodríguez-Otero Paula , Reguera Juan Luis , Moreno David F. , Martínez-Cibrian Nuria , López-Corral Lucía , Pérez-Amill Lorena , Martin-Antonio Beatriz , Rosiñol Laura , Cid Joan , Tovar Natalia , Sáez-Peñataro Joaquín , López-Parra Miriam , Olesti Eulalia , Guillén Elena , Varea Sara , Rodríguez-Lobato Luis Gerardo , Battram Anthony M. , González Marta Sonia , Sánchez-Salinas Andrés , González-Navarro Azucena , Ortiz-Maldonado Valentín , Delgado Julio , Prósper Felipe , Juan Manel , Martínez-López Joaquín , Moraleda José M. , Mateos Maria Victoria , Urbano-Ispizua Álvaro , Paiva Bruno , Pascal Mariona , Fernández de Larrea Carlos
Published: May 2024

Supplementary Methods
Supplementary Video S1 from Circulating microRNA Analysis in a Prospective Co-clinical Trial Identifies MIR652–3p as a Response Biomarker and Driver of Regorafenib Resistance Mechanisms in Colorectal Cancer
Authors: Hedayat Somaieh , Cascione Luciano , Cunningham David , Schirripa Marta , Lampis Andrea , Hahne Jens C. , Tunariu Nina , Hong Sung Pil , Marchetti Silvia , Khan Khurum , Fontana Elisa , Angerilli Valentina , Delrieux Mia , Nava Rodrigues Daniel , Procaccio Letizia , Rao Sheela , Watkins David , Starling Naureen , Chau Ian , Braconi Chiara , Fotiadis Nicos , Begum Ruwaida , Guppy Naomy , Howell Louise , Valenti Melanie , Cribbes Scott , Kolozsvari Bernadett , Kirkin Vladimir , Lonardi Sara , Ghidini Michele , Passalacqua Rodolfo , Elghadi Raghad , Magnani Luca , Pinato David J. , Di Maggio Federica , Ghelardi Filippo , Sottotetti Elisa , Vetere Guglielmo , Ciracì Paolo , Vlachogiannis Georgios , Pietrantonio Filippo , Cremolini Chiara , Cortellini Alessio , Loupakis Fotios , Fassan Matteo , Valeri Nicola
Published: May 2024

1021BL co-culture
Supplementary Figure S11 from Biomarkers of Efficacy and Safety of the Academic BCMA-CART ARI0002h for the Treatment of Refractory Multiple Myeloma
Authors: Oliver-Caldes Aina , Español-Rego Marta , Zabaleta Aintzane , González-Calle Verónica , Navarro-Velázquez Sergio , Inogés Susana , de Cerio Ascensión López-Díaz , Cabañas Valentín , López-Muñoz Nieves , Rodríguez-Otero Paula , Reguera Juan Luis , Moreno David F. , Martínez-Cibrian Nuria , López-Corral Lucía , Pérez-Amill Lorena , Martin-Antonio Beatriz , Rosiñol Laura , Cid Joan , Tovar Natalia , Sáez-Peñataro Joaquín , López-Parra Miriam , Olesti Eulalia , Guillén Elena , Varea Sara , Rodríguez-Lobato Luis Gerardo , Battram Anthony M. , González Marta Sonia , Sánchez-Salinas Andrés , González-Navarro Azucena , Ortiz-Maldonado Valentín , Delgado Julio , Prósper Felipe , Juan Manel , Martínez-López Joaquín , Moraleda José M. , Mateos Maria Victoria , Urbano-Ispizua Álvaro , Paiva Bruno , Pascal Mariona , Fernández de Larrea Carlos
Published: May 2024

Figure 11. Progression-free survival according to MRD-negative sensitivity on day 28.
Supplementary Data 1 from Onvansertib in Combination with FOLFIRI and Bevacizumab in Second-Line Treatment of KRAS-Mutant Metastatic Colorectal Cancer: A Phase Ib Clinical Study
Authors: Ahn Daniel H. , Barzi Afsaneh , Ridinger Maya , Samuëlsz Errin , Subramanian Ramanand A. , Croucher Peter J.P. , Smeal Tod , Kabbinavar Fairooz F. , Lenz Heinz-Josef
Published: May 2024

Supplementary figure and tables
Supplementary Table S5 from Integrative Molecular Analyses of the MD Anderson Prostate Cancer Patient-derived Xenograft (MDA PCa PDX) Series
Authors: Anselmino Nicolas , Labanca Estefania , Shepherd Peter D.A. , Dong Jiabin , Yang Jun , Song Xiaofei , Nandakumar Subhiksha , Kundra Ritika , Lee Cindy , Schultz Nikolaus , Zhang Jianhua , Araujo John C. , Aparicio Ana M. , Subudhi Sumit K. , Corn Paul G. , Pisters Louis L. , Ward John F. , Davis John W. , Vazquez Elba S. , Gueron Geraldine , Logothetis Christopher J. , Futreal Andrew , Troncoso Patricia , Chen Yu , Navone Nora M.
Published: May 2024

Clinical, morphological and molecular features of MDA PCa PDXs pairs derived from the same patient
Supplementary Figure S4 from Integrative Molecular Analyses of the MD Anderson Prostate Cancer Patient-derived Xenograft (MDA PCa PDX) Series
Authors: Anselmino Nicolas , Labanca Estefania , Shepherd Peter D.A. , Dong Jiabin , Yang Jun , Song Xiaofei , Nandakumar Subhiksha , Kundra Ritika , Lee Cindy , Schultz Nikolaus , Zhang Jianhua , Araujo John C. , Aparicio Ana M. , Subudhi Sumit K. , Corn Paul G. , Pisters Louis L. , Ward John F. , Davis John W. , Vazquez Elba S. , Gueron Geraldine , Logothetis Christopher J. , Futreal Andrew , Troncoso Patricia , Chen Yu , Navone Nora M.
Published: May 2024

Detail of manually curated full or partial copy number/ transcript loss