bluuebunny/crossref_metadata_2025 huggingface dataset:
Mining and the scalar transformations of the state in the Democratic Republic of Congo
Authors: Rubbers Benjamin
Published: June 2023

This article reflects on the effects of the recent mining boom on the (trans-)formation of the state in D.R. Congo. To do so, it proposes to integrate macro- and micro- approaches to the political economy of mining into a broader analysis of the power practices of actors at different levels of the state apparatus. Taking the copper mining sector as a case study, it explores the various means by which the presidency, provincial authorities and customary chiefs have drawn resources from mining in the period from the early 2000s to the present. This analysis highlights the various resources that state actors at different levels use to assert their authority over foreign mining companies. From a broader perspective, it shows that, although the liberalisation of the mining sector has opened up new revenue opportunities for all these actors, it has not resulted in a significant power redistribution between them.
Conservancies, rainfall anomalies and communal violence: subnational evidence from East Africa
Authors: Sánchez Alfonso , Fernandez Alvaro , González Juan B.
Published: June 2023

Are conservancies hotspots for communal violence and if so, do rainfall anomalies increase the likelihood of violence? The consensus from a rich number of case studies suggests that conservancies (e.g. national parks, game reserves) increase tensions between communities, which often lead to violent conflicts. Yet, these insights remain to be empirically tested using a large-N study. We examine this claim and explore if rainfall anomalies have an amplifying effect on violent conflicts. We contend that the spatial convergence between conservancies and rainfall variability can spark conflicts over access to resources in times of scarcity and create strategic opportunities to satisfy secondary goals in times of abundance. To test our expectations, we use sub-national data from East Africa between 1990 and 2018. Our results suggest that regions with conservancies are somewhat more prone to communal violence and find strong evidence that positive rainfall anomalies increase the likelihood of violent communal conflicts in regions with a conservancy.
African regionalism, economic nationalism and the contested politics of social purpose: the East African Community and the ‘new developmentalism’
Authors: O'Reilly Peter
Published: June 2023

Over the last decade, a new developmentalism has taken root across Africa, centred on promoting local production and industrialisation. One unintended consequence of this has been the proliferation of economically nationalist policy measures that have increasingly come into tension with the aims of regional integration in Africa. This article sets out to offer insights as to why these tensions are emerging by focusing on the East African Community (EAC) and the growing trend of economic nationalism among its members. Contrary to what rationalist and structuralist accounts might presume, this article argues that this rise in economic nationalism is instead reflective of a weakening of the discursive imperative – or social purpose – that had initially converged various actors around the EAC's integration agenda when revived in 2000. While drawing from the EAC's experience, it concludes by highlighting a broader legitimacy dilemma facing African regional organisations within this ‘new developmentalism’.
Equality, Proportionality and Statistics: Political Representation from the English to the French and American Revolutions
Authors: Behrisch Lars
Published: June 2023

Debates on the proportionality of political representation surfaced repeatedly, and in similar forms, from the English to the American and French Revolutions. They contributed to shaping those revolutions’ outcomes and, through them, to the emergence of modern democracy – especially so as they were linked up with voting rights: demands to make seats in assemblies more numerically proportionate to electorates – in other words, to weigh all votes equally – implied the equal weight of individual votes and thus also entailed calls for more equal standards regarding the right to vote. This did not yet signify voting rights for all: only specific categories of individuals – as a rule, male and propertied – were considered, even by the most ‘enlightened’ writers, to be politically entitled. Nevertheless, it was only one step from here to envisage voting rights for all individuals – or at least, for the time being, for all male individuals – as can also be seen in all three revolutions. If claims for more proportional and equal representation showed their full impact only on the American and French Revolutions, finally, this was due to the intervening emergence of statistics (or ‘political arithmetic’) as a tool of reflection and debate that gave numbers and calculations increasing persuasive power.
A 94.1 g scissors-type dual-arm cooperative manipulator for plant sampling by an ornithopter using a vision detection system
Authors: Rafee Nekoo Saeed , Feliu-Talegon Daniel , Tapia Raul , Satue Alvaro C. , Martínez-de Dios Jose Ramiro , Ollero Anibal
Published: June 2023

The sampling and monitoring of nature have become an important subject due to the rapid loss of green areas. This work proposes a possible solution for a sampling method of the leaves using an ornithopter robot equipped with an onboard 94.1 g dual-arm cooperative manipulator. One hand of the robot is a scissors-type arm and the other one is a gripper to perform the collection, approximately similar to an operation by human fingers. In the move toward autonomy, a stereo camera has been added to the ornithopter to provide visual feedback for the stem, which reports the position of the cutting and grasping. The position of the stem is detected by a stereo vision processing system and the inverse kinematics of the dual-arm commands both gripper and scissors to the right position. Those trajectories are smooth and avoid any damage to the actuators. The real-time execution of the vision algorithm takes place in the lightweight main processor of the ornithopter which sends the estimated stem localization to a microcontroller board that controls the arms. The experimental results both indoors and outdoors confirmed the feasibility of this sampling method. The operation of the dual-arm manipulator is done after the perching of the system on a stem. The topic of perching has been presented in previous works and here we focus on the sampling procedure and vision/manipulator design. The flight experimentation also approves the weight of the dual-arm system for installation on the flapping-wing flying robot.
The Illusion of Merit in Political Leadership Selection in China
Authors: Zhao Mengxue , Ma Liang , Chan Hon S.
Published: June 2023

In China, government at all levels relies on the specially selected graduates (SSG) scheme to recruit elite university students as future political leaders. This article examines the mechanism of the SSG scheme and the relationship between elite university education and political selection in China. We show that elite education is increasingly stratified, such that graduates from top elite universities have significant selection advantages in the SSG competition and are more likely to be offered incentives and preferences. We argue that taking elite university education as a hard eligibility criterion reinforces the homophily effects in selection of future political elites and strengthens the political influence of top elite universities on China's politics. Further, because poor and lower-class students have little chance of entering elite universities, the SSG does not provide an effective route of upward mobility for non-elite classes. Merit-based political recruitment as a channel of upward mobility for non-elite classes is largely an illusion.
Striking distance: Investigating the epigraphy and geography of a Late Classic Maya war
Authors: Carter Nicholas P. , Krause Samantha , Lozano Jacob
Published: June 2023

We present a photogrammetric model and new line drawing of Sacul Stela 3 at the ancient Maya site of Sacul 1, Guatemala. Although virtually illegible in person and from photographs, the inscription on the eroded stela can largely be read or reconstructed in the 3D model. Our reading confirms a previous argument that the kingdom based at Sacul 1 was attacked in A.D. 779 by forces from the site of Ucanal. Traveling by night, warriors from Sacul retaliated with a raid at dawn next day on an unidentified site and, months later, followed up with an attack on Ucanal itself. The same narrative appears substantially on a well-known monument, Ixkun Stela 2, but there are differences between the two texts which suggest that Sacul and Ixkun had their own sculptors and record-keepers and which offer insights into the implications of verbs (pul, “to burn” and ch'ak, “to chop”) commonly attested in Classic Maya accounts of war. We then present the results of GIS analysis which suggests that the site area of El Rosario (between Sacul 1 and Ucanal) is an appealing candidate for the unidentified site mentioned in the stela text.
Parental communication satisfaction with the clinical team in the paediatric cardiac ICU
Authors: Walter Jennifer K. , Feudtner Chris , Cetin Arzu , DeWitt Aaron G. , Zhou Michelle , Montoya-Williams Diana , Olsen Rob , Griffis Heather , Williams Catherine , Costarino Andrew
Published: June 2023

Introduction

Understanding parents’ communication preferences and how parental and child characteristics impact satisfaction with communication is vital to mitigate communication challenges in the cardiac ICU.

Methods

This cross-sectional survey was conducted from January 2019 to March 2020 in a paediatric cardiac ICU with parents of patients admitted for at least two weeks. Family satisfaction with communication with the medical team was measured using the Communication Assessment Tool for Team settings. Clinical characteristics were collected via Epic, Pediatric Cardiac Critical Care Consortium local entry and Society for Thoracic Surgeons Congenital Heart Surgery Databases. Associations between communication score and parental mood, stress, perceptions of clinical care, and demographic characteristics along with patient demographic and clinical characteristics were examined. Multivariable ordinal models were conducted with characteristics significant in bivariate analysis.

Results

In total, 93 parents of 84 patients (86% of approached) completed surveys. Parents were 63% female and 70% White. Seventy per cent of patients were <6 months old at admission, 25% had an extracardiac abnormality, and 80% had a cardiac surgery this admission. Parents of children with higher pre-surgical risk of mortality scores (OR 2.875; 95%CI 1.076–7.678), presence of surgical complications (72 [63.0, 75.0] vs. 64 [95%CI 54.6, 73] (p = 0.0247)), and greater satisfaction with care in the ICU (r = 0.93922; p < 0.0001) had significantly higher communication scores.

Conclusion

These findings can prepare providers for scenarios with higher risk for communication challenges and demonstrate the need for further investigation into interventions that reduce parental anxiety and improve communication for patients with unexpected clinical trajectories
Hospital, hospice, or home: A scoping review of the importance of place in pediatric palliative care
Authors: Walker Meaghan , Nicolardi Danielle , Christopoulos Téa , Ross Timothy
Published: June 2023

Background

Palliative care necessitates questions about the preferred place for delivering care and location of death. Place is integral to palliative care, as it can impact proximity to family, available resources/support, and patient comfort. Despite the importance of place, there is remarkably little literature exploring its role in pediatric palliative care (PPC).

Objectives

To understand the importance and meaning of place in PPC.

Methods

We conducted a scoping review to understand the importance of place in PPC. Five databases were searched using keywords related to “pediatric,” “palliative,” and “place.” Two reviewers screened results, extracted data, and analyzed emergent themes pertaining to place.

Results

From 3076 search results, we identified and reviewed 25 articles. The literature highlights hospital, home, and hospice as 3 distinct PPC places. Children and their families have place preferences for PPC and place of death, and a growing number prefer death to occur at home. Results also indicate numerous factors influence place preferences (e.g., comfort, grief, cultural/spiritual practices, and socioeconomic status).

Significance of results

Place influences families’ PPC decisions and experiences and thus warrants further study. Greater understanding of the importance and roles of place in PPC could enhance PPC policy and practice, as well as PPC environments.
Metamaterial-based electromagnetically induced transparency-like sensor design with low-volume sliding dielectric loadings
Authors: Cetin Hasan , Ekmekci Evren
Published: June 2023

In this study, tunability of the electromagnetically induced transparency (EIT)-like transmission window by low-volume dielectric loadings is presented both numerically and experimentally in S-band. The EIT-like transmission behavior is obtained by a metamaterial, composed of an electric resonator and a closed-ring resonator patterned on a dielectric substrate. The frequency tuning is obtained by two applications called horizontal sliding application (HSA) and vertical sliding application based on sliding of the low-volume loadings from the edges to geometric center (i.e., inward). For both applications, the frequency tuning has been investigated for dielectric loadings which have relative permittivity of 2.2, 3, 4.5, and 6.15. The results reveal that the proposed sliding applications are effective on tuning the transmission peak frequency. An achieved 1136 and 971 MHz absolute spectral shifts and corresponding 6.34% and 5.41% absolute sensitivities by simulations and measurements, respectively, are the best results which are obtained for HSA at 5 mm shift value. Moreover, 14.67% sensitivity is obtained in simulations for the complete dielectric loading on the resonator in response to the increase in refractive index from 1 to 1.5. It is believed that the proposed applications will contribute to the existent sensing studies.
Using soybean chaff lining to manage waterhemp (Amaranthus tuberculatus) in a soybean–corn rotation
Authors: Bennett Avery J. , Yadav Ramawatar , Jha Prashant
Published: June 2023

Waterhemp (Amaranthus tuberculatus[Moq.] Sauer) escapes are common in midwestern U.S. soybean [Glycine max(L.) Merr.] fields due to the continued rise in herbicide-resistant (HR) populations. In a conventional harvesting system, weed seeds are harvested with the crop grain and spread back on to the field. Harvest weed seed control methods such as chaff lining concentrate weed seed-bearing crop and weed chaff into a narrow row (chaff line). These chaff lines (30- to 50-cm wide) are undisturbed the following growing seasons, under the assumption that the chaff line creates an environment less favorable for weed seed germination and survival. Field experiments were conducted in a soybean–corn (Zea maysL.) rotation in 2020 and 2021 in Ames, IA, and Roland, IA, to quantify the effectiveness of chaff lining for managingA. tuberculatusseeds. About 70% of theA. tuberculatusseeds were retained on the mother plant at soybean harvest in 2020. The chaff lining system concentrated more than 99% of theA. tuberculatusseeds exiting the combine into the chaff line. AlthoughA. tuberculatuspopulation density in 2021 was 76% higher inside the chaff line than outside the chaff line,A. tuberculatusaboveground biomass was 63% lower inside the chaff line than outside the chaff line at 12 wk after corn planting. Similarly,A. tuberculatusinside the chaff line had delayed emergence compared withA. tuberculatusoutside the chaff line. Application of preemergence herbicides in corn inside the chaff line delayedA. tuberculatusemergence by more than 2 wk compared withA. tuberculatusoutside the chaff line. Additionally, a follow-up postemergence herbicide application in corn was needed only inside the chaff line to manageA. tuberculatus, suggesting the possibility of lower overall herbicide use. These results support implementing chaff lining in soybean-based crop systems of the U.S. Midwest to help manage HRA. tuberculatusseedbanks.
Statistical Uncertainty in the Frequency Dependence of the Intensity Scintillation Index (S4)
Authors: Sun Andrew K. , Pi Xiaoqing , Rino Charles , Lee Jiyun
Published: June 2023

The intensity scintillation index (S4) exhibits a linear frequency dependence derived from a power law phase screen model, with the exponent determined by the phase spectral index (p). However, it is well known that a departure from linearity occurs as S4 increases and saturates under strong scatter conditions. Additionally, statistical errors over a finite time window can also cause the scintillation statistic to deviate from the power law dependence on frequency. This paper presents a parametric analysis on the deviation in the S4 frequency dependence from the power law form. This investigation focuses on the contribution of statistical uncertainty in S4 calculations to the deviation in the frequency dependence according to the selected parameters: S4 and Fresnel frequency (fF). The deviation is determined by comparing p estimates calculated from the power law relationship of S4 at different L‐band frequencies with those inferred from a model‐fitting method using a multi‐frequency global navigation satellite system scintillation data set. The results show the well‐known departure from linearity as S4 increases, and reveal increasing deviations with decreasing fF. The spectral analysis indicates that the variability at the lowest frequencies of intensity spectra contributes to the statistical errors in S4 calculations due to the finite time window, particularly when scintillations are dominated by low‐frequency contributions at low fF. Simulation results of scintillation realizations show much lower deviations with a 30‐min compared to 1‐min window. This suggests a 1‐min window can be too short for reliable S4 calculations due to statistical uncertainty, especially at low fF.
Understanding the mechanism of action and clinical effects of neuroactive steroids and GABAergic compounds in major depressive disorder
Authors: Cutler Andrew J. , Mattingly Gregory W. , Maletic Vladimir
Published: June 2023

The pathophysiology of major depressive disorder (MDD) is thought to result from impaired connectivity between key brain networks. Gamma-aminobutyric acid (GABA) is the key inhibitory neurotransmitter in the brain, working primarily via GABAAreceptors, with an important role in virtually all physiologic functions in the brain. Some neuroactive steroids (NASs) are positive allosteric modulators (PAMs) of GABAAreceptors and potentiate phasic and tonic inhibitory responses via activation of synaptic and extrasynaptic GABAAreceptors, respectively. This review first discusses preclinical and clinical data that support the association of depression with diverse defects in the GABAergic system of neurotransmission. Decreased levels of GABA and NASs have been observed in adults with depression compared with healthy controls, while treatment with antidepressants normalized the altered levels of GABA and NASs. Second, as there has been intense interest in treatment approaches for depression that target dysregulated GABAergic neurotransmission, we discuss NASs approved or currently in clinical development for the treatment of depression. Brexanolone, an intravenous NAS and a GABAAreceptor PAM, is approved by the U.S. Food and Drug Administration for the treatment of postpartum depression (PPD) in patients 15 years and older. Other NASs include zuranolone, an investigational oral GABAAreceptor PAM, and PH10, which acts on nasal chemosensory receptors; clinical data to date have shown improvement in depressive symptoms with these investigational NASs in adults with MDD or PPD. Finally, the review discusses how NAS GABAAreceptor PAMs may potentially address the unmet need for novel and effective treatments with rapid and sustained antidepressant effects in patients with MDD.
Border-associated macrophages mediate the neuroinflammatory response in an alpha-synuclein model of Parkinson disease
Authors: Schonhoff A. M. , Figge D. A. , Williams G. P. , Jurkuvenaite A. , Gallups N. J. , Childers G. M. , Webster J. M. , Standaert D. G. , Goldman J. E. , Harms A. S.
Published: June 2023

Dopaminergic cell loss due to the accumulation of α-syn is a core feature of the pathogenesis of Parkinson disease. Neuroinflammation specifically induced by α-synuclein has been shown to exacerbate neurodegeneration, yet the role of central nervous system (CNS) resident macrophages in this process remains unclear. We found that a specific subset of CNS resident macrophages, border-associated macrophages (BAMs), play an essential role in mediating α-synuclein related neuroinflammation due to their unique role as the antigen presenting cells necessary to initiate a CD4 T cell response whereas the loss of MHCII antigen presentation on microglia had no effect on neuroinflammation. Furthermore, α-synuclein expression led to an expansion in border-associated macrophage numbers and a unique damage-associated activation state. Through a combinatorial approach of single-cell RNA sequencing and depletion experiments, we found that border-associated macrophages played an essential role in immune cell recruitment, infiltration, and antigen presentation. Furthermore, border-associated macrophages were identified in post-mortem PD brain in close proximity to T cells. These results point to a role for border-associated macrophages in mediating the pathogenesis of Parkinson disease through their role in the orchestration of the α-synuclein-mediated neuroinflammatory response.
Post-synthetic modification of covalent organic frameworks for CO2 electroreduction
Authors: Liu Minghao , Yang Shuai , Yang Xiubei , Cui Cheng-Xing , Liu Guojuan , Li Xuewen , He Jun , Chen George Zheng , Xu Qing , Zeng Gaofeng
Published: June 2023

To achieve high-efficiency catalysts for CO2reduction reaction, various catalytic metal centres and linker molecules have been assembled into covalent organic frameworks. The amine-linkages enhance the binding ability of CO2molecules, and the ionic frameworks enable to improve the electronic conductivity and the charge transfer along the frameworks. However, directly synthesis of covalent organic frameworks with amine-linkages and ionic frameworks is hardly achieved due to the electrostatic repulsion and predicament for the strength of the linkage. Herein, we demonstrate covalent organic frameworks for CO2reduction reaction by modulating the linkers and linkages of the template covalent organic framework to build the correlation between the catalytic performance and the structures of covalent organic frameworks. Through the double modifications, the CO2binding ability and the electronic states are well tuned, resulting in controllable activity and selectivity for CO2reduction reaction. Notably, the dual-functional covalent organic framework achieves high selectivity with a maximum CO Faradaic efficiency of 97.32% and the turnover frequencies value of 9922.68 h−1, which are higher than those of the base covalent organic framework and the single-modified covalent organic frameworks. Moreover, the theoretical calculations further reveal that the higher activity is attributed to the easier formation of immediate *CO from COOH*. This study provides insights into developing covalent organic frameworks for CO2reduction reaction.
Sparse representation for machine learning the properties of defects in 2D materials
Authors: Kazeev Nikita , Al-Maeeni Abdalaziz Rashid , Romanov Ignat , Faleev Maxim , Lukin Ruslan , Tormasov Alexander , Castro Neto A. H. , Novoselov Kostya S. , Huang Pengru , Ustyuzhanin Andrey
Published: June 2023

Two-dimensional materials offer a promising platform for the next generation of (opto-) electronic devices and other high technology applications. One of the most exciting characteristics of 2D crystals is the ability to tune their properties via controllable introduction of defects. However, the search space for such structures is enormous, and ab-initio computations prohibitively expensive. We propose a machine learning approach for rapid estimation of the properties of 2D material given the lattice structure and defect configuration. The method suggests a way to represent configuration of 2D materials with defects that allows a neural network to train quickly and accurately. We compare our methodology with the state-of-the-art approaches and demonstrate at least 3.7 times energy prediction error drop. Also, our approach is an order of magnitude more resource-efficient than its contenders both for the training and inference part.
Machine-learning driven global optimization of surface adsorbate geometries
Authors: Jung Hyunwook , Sauerland Lena , Stocker Sina , Reuter Karsten , Margraf Johannes T.
Published: June 2023

The adsorption energies of molecular adsorbates on catalyst surfaces are key descriptors in computational catalysis research. For the relatively large reaction intermediates frequently encountered, e.g., in syngas conversion, a multitude of possible binding motifs leads to complex potential energy surfaces (PES), however. This implies that finding the optimal structure is a difficult global optimization problem, which leads to significant uncertainty about the stability of many intermediates. To tackle this issue, we present a global optimization protocol for surface adsorbate geometries which trains a surrogate machine learning potential on-the-fly. The approach is applicable to arbitrary surface models and adsorbates and minimizes both human intervention and the number of required DFT calculations by iteratively updating the training set with configurations explored by the algorithm. We demonstrate the efficiency of this approach for a diverse set of adsorbates on the Rh(111) and (211) surfaces.
High-throughput screening of zwitterion-based coatings towards improved mechanical stability and drug-loading capacity
Authors: Yang Jingzhi , Ran Yami , Huang Luyao , Ren Chenhao , Hao Xiangping , Ma Lingwei , Zhang Dawei
Published: June 2023

2-hydroxyethyl methacrylate (HEMA), poly(ethylene glycol) (PEG), and zwitterionic polymers are currently considered the most extensively studied antifouling hydrogel coatings. However, systematic identification of these coatings to unleash their potential properties is tremendously under-represented. Here, we report a high-throughput optimizing strategy that combines highly miniaturized hydrogel synthesis and screening to fine design zwitterion-based hydrogel coatings. Compared with the traditional one-by-one synthesis and characterization methods, the proposed high-throughput strategy accelerated the discovery of candidate materials with a high-efficiency and cost-effective approach. To tailor multiple parameters of coatings, 1575 unique coating combinations with continuous gradients were prepared only required 600 μL reactant. The mechanical stability and drug-loading capacity of the coating spots were sequentially evaluated via immersion swelling, flow, tape-peeling, and dye-retaining tests. This strategy could efficiently reveal the composition/structure-function relationships of the hydrogel coatings and also other materials, which is promising for the rapid screening and design of desired implantable device surfaces.
Posterior scleral birefringence measured by triple-input polarization-sensitive imaging as a biomarker of myopia progression
Authors: Liu Xinyu , Jiang Liqin , Ke Mengyuan , Sigal Ian A. , Chua Jacqueline , Hoang Quan V. , Chia Audrey WI. , Najjar Raymond P. , Tan Bingyao , Cheong Jocelyn , Bellemo Valentina , Chong Rachel S. , Girard Michaël J. A. , Ang Marcus , Liu Mengyang , Garhöfer Gerhard , Barathi Veluchamy A. , Saw Seang-Mei , Villiger Martin , Schmetterer Leopold
Published: June 2023

In myopic eyes, pathological remodelling of collagen in the posterior sclera has mostly been observed ex vivo. Here we report the development of triple-input polarization-sensitive optical coherence tomography (OCT) for measuring posterior scleral birefringence. In guinea pigs and humans, the technique offers superior imaging sensitivities and accuracies than dual-input polarization-sensitive OCT. In 8-week-long studies with young guinea pigs, scleral birefringence was positively correlated with spherical equivalent refractive errors and predicted the onset of myopia. In a cross-sectional study involving adult individuals, scleral birefringence was associated with myopia status and negatively correlated with refractive errors. Triple-input polarization-sensitive OCT may help establish posterior scleral birefringence as a non-invasive biomarker for assessing the progression of myopia.
Co-electrolysis of seawater and carbon dioxide inside a microfluidic reactor to synthesize speciality organics
Authors: Rarotra Saptak , Singh Amit Kumar , Mandal Tapas Kumar , Bandyopadhyay Dipankar
Published: June 2023

We report co-electrolysis of seawater and carbon dioxide (CO2) gas in a solar cell-integrated membraneless microfluidic reactor for continuous synthesis of organic products. The microfluidic reactor was fabricated using polydimethylsiloxane substrate comprising of a central microchannel with a pair of inlets for injection of CO2 gas and seawater and an outlet for removal of organic products. A pair of copper electrodes were inserted into microchannel to ensure its direct interaction with incoming CO2 gas and seawater as they pass into the microchannel. The coupling of solar cell panels with electrodes generated a high-intensity electrical field across the electrodes at low voltage, which facilitated the co-electrolysis of CO2 and seawater. The paired electrolysis of CO2 gas and seawater produced a range of industrially important organics under influence of solar cell-mediated external electric field. The, as synthesized, organic compounds were collected downstream and identified using characterization techniques. Furthermore, the probable underlying electrochemical reaction mechanisms near the electrodes were proposed for synthesis of organic products. The inclusion of greenhouse CO2 gas as reactant, seawater as electrolyte, and solar energy as an inexpensive electric source for co-electrolysis initiation makes the microreactor a low-cost and sustainable alternative for CO2 sequestration and synthesis of organic compounds.
Early Pleistocene cut marked hominin fossil from Koobi Fora, Kenya
Authors: Pobiner Briana , Pante Michael , Keevil Trevor
Published: June 2023

Identification of butchery marks on hominin fossils from the early Pleistocene is rare. Our taphonomic investigation of published hominin fossils from the Turkana region of Kenya revealed likely cut marks on KNM-ER 741, a ~ 1.45 Ma proximal hominin left tibia shaft found in the Okote Member of the Koobi Fora Formation. An impression of the marks was created with dental molding material and scanned with a Nanovea white-light confocal profilometer, and the resulting 3-D models were measured and compared with an actualistic database of 898 individual tooth, butchery, and trample marks created through controlled experiments. This comparison confirms the presence of multiple ancient cut marks that are consistent with those produced experimentally. These are to our knowledge the first (and to date only) cut marks identified on an early Pleistocene postcranial hominin fossil.
Cytokine profiles in adults with imported malaria
Authors: de Roquetaillade Charles , Laouenan Cédric , Mira Jean-Paul , Roy Carine , Thuong Marie , Azoulay Élie , Gruson Didier , Jacobs Frédéric , Chommeloux Juliette , Raffi François , Hocqueloux Laurent , Imbert Patrick , Jeantils Vincent , Delassus Jean-Luc , Matheron Sophie , Fitting Catherine , Timsit Jean-François , Bruneel Fabrice
Published: June 2023

The increase in worldwide travel is making imported malaria a growing health concern in non-endemic countries. Most data on the pathophysiology of malaria come from endemic areas. Little is known about cytokine profiles during imported malaria. This study aimed at deciphering the relationship between cytokine host response and malaria severity among imported cases in France. This study reports cytokine profiles in adults with Plasmodium falciparum malaria included in the PALUREA prospective study conducted between 2006 and 2010. The patients were classified as having uncomplicated malaria (UM) or severe malaria (SM), with this last further categorized as very severe malaria (VSM) or less severe malaria (LSM). At hospital admission, eight blood cytokines were assayed in duplicate using Luminex® technology: interleukin (IL)-1α, IL-1β, IL-2, IL-4, IL-10, tumor necrosis factor (TNF)α, interferon (IFN)γ, and macrophage migration inhibitory factor (MIF). These assays were repeated on days 1 and 2 in the SM group. Of the 278 patients, 134 had UM and 144 SM. At hospital admission, over half the patients had undetectable levels of IL-1α, IL-1β, IL-2, IL-4, IFNγ, and TNFα, while IL-10 and MIF were significantly higher in the SM vs. the UM group. Higher IL-10 was significantly associated with higher parasitemia (R = 0.32 [0.16–0.46]; P = 0.0001). In the SM group, IL-10 elevation persisting from admission to day 2 was significantly associated with subsequent nosocomial infection. Of eight tested cytokines, only MIF and IL-10 were associated with disease severity in adults with imported P. falciparum malaria. At admission, many patients had undetectable cytokine levels, suggesting that circulating cytokine assays may not be helpful as part of the routine evaluation of adults with imported malaria. Persisting high IL-10 concentration was associated with subsequent nosocomial infection, suggesting its possible interest in immune monitoring of most severe patients.
Preparation of multifunctional hydrogels with accessible isothiouronium groups via radical cross-linking copolymerization
Authors: Grübel Jana , L. Albernaz Vanessa , Tsianaka Anastasia , Jauch Corinna O. , Quirin Silia , Kerger Christian , Kohl Christina G. , Burger-Kentischer Anke , Tovar Günter E. M. , Southan Alexander
Published: June 2023

Hydrogels can be equipped with functional groups for specific purposes. Isothiouronium groups can enhance adsorptivity, or allow coupling of other functional groups through mild reactions after transformation to thiol groups. Here we present a method to prepare multifunctional hydrogels by introducing isothiouronium groups into poly(ethylene glycol) diacrylate (PEGDA) hydrogels, and convert them into thiol-functionalized hydrogels by the reduction of the isothiouronium groups. For this purpose, the amphiphilic monomer 2-(11-(acryloyloxy)-undecyl)isothiouronium bromide (AUITB), containing an isothiouronium group, was synthesized and copolymerized with PEGDA. In this convenient way, it was possible to incorporate up to 3 wt% AUITB into the hydrogels without changing their equilibrium swelling degree. The successful functionalization was demonstrated by surface analysis of the hydrogels with water contact angle measurements and increased isoelectric points of the hydrogel surfaces from 4.5 to 9.0 due to the presence of the isothiouronium groups. The hydrogels showed a suitability as an adsorbent, as exemplified by the pronounced adsorption of the anionic drug diclofenac. The potential of the functionalization for (bio)conjugation reactions was demonstrated by the reduction of isothiouronium groups to thiols and subsequent immobilization of the functional enzyme horseradish peroxidase on the hydrogels. The results show that fully accessible isothiouronium groups can be introduced into radically cross-linked hydrogels.
Improved psychosocial measures associated with physical activity may be explained by alterations in brain-gut microbiome signatures
Authors: Guan Michelle , Dong Tien S. , Subramanyam Vishvak , Guo Yiming , Bhatt Ravi R. , Vaughan Allison , Barry Robert L. , Gupta Arpana
Published: June 2023

Obesity contributes to physical comorbidities and mental health consequences. We explored whether physical activity could influence more than metabolic regulation and result in psychological benefits through the brain-gut microbiome (BGM) system in a population with high BMI. Fecal samples were obtained for 16 s rRNA profiling and fecal metabolomics, along with psychological and physical activity questionnaires. Whole brain resting-state functional MRI was acquired, and brain connectivity metrics were calculated. Higher physical activity was significantly associated with increased connectivity in inhibitory appetite control brain regions, while lower physical activity was associated with increased emotional regulation network connections. Higher physical activity was also associated with microbiome and metabolite signatures protective towards mental health and metabolic derangements. The greater resilience and coping, and lower levels of food addiction seen with higher physical activity, may be explained by BGM system differences. These novel findings provide an emphasis on the psychological and resilience benefits of physical activity, beyond metabolic regulation and these influences seem to be related to BGM interactions.
Inflammatory biomarkers at different stages of Sarcopenia in older women
Authors: da Costa Teixeira Leonardo Augusto , Avelar Nubia Carelli Pereira , Peixoto Marco Fabrício Dias , Parentoni Adriana Netto , Santos Jousielle Marcia dos , Pereira Fabiana Souza Máximo , Danielewicz Ana Lúcia , Leopoldino Amanda Aparecida Oliveira , Costa Sabrina Paula , Arrieiro Arthur Nascimento , Soares Luana Aparecida , da Silva Lage Vanessa Kelly , Prates Ana Caroline Negreiro , Taiar Redha , de Carvalho Bastone Alessandra , Oliveira Vinicius Cunha de , Oliveira Murilo Xavier , Costa Henrique Silveira , Nobre Juliana Nogueira Pontes , Brant Franciane Pereira , Duarte Tamiris Campos , Figueiredo Pedro Henrique Scheidt , Mendonça Vanessa Amaral , Lacerda Ana Cristina Rodrigues
Published: June 2023

In recent years, studies have found that Sarcopenia alters inflammatory biomarkers. However, the behavior of inflammatory biomarkers at different stages of Sarcopenia is not well understood. This study aimed to compare a broad panel of inflammatory biomarkers in older women at different stages of Sarcopenia. The study included 71 Brazilian community-dwelling older women. Muscle Strength was assessed by using handgrip strength (Jamar dynamometer). The Short Physical Performance Battery (SPPB) was performed to assess the physical performance, and body composition was assessed by DEXA. Sarcopenia was diagnosed and classified according to the EWGSOP2 criteria. Blood was drawn, and inflammatory biomarkers associated with Sarcopenia (IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, TNF, adiponectin, leptin, resistin, BDNF, sTNFr-1 and sTNFr-2) was analysed. After diagnosis and classification of sarcopenia, 45% of women did not present Sarcopenia (NS, N = 32), 23.9% were diagnosed with Sarcopenia Probable (SP, N = 17), 19,7% with Sarcopenia Confirmed (SC, N = 14), and 11.3% with Severe Sarcopenia (SS, N = 8). The analysis of inflammatory biomarkers revealed that the more advanced the stage of Sarcopenia, the higher the levels of BDNF, IL-8, sTNFr-1, and sTNFr-2. The assessment of BDNF, IL-8, sTNFr-1, and sTNFr-2 levels may be an adjuvant tool in diagnosis and severity classification of Sarcopenia in older Brazilian women.
Modelling COVID-19 pandemic control strategies in metropolitan and rural health districts in New South Wales, Australia
Authors: Rahman Azizur , Kuddus Md Abdul , Ip Ryan H. L. , Bewong Michael
Published: June 2023

COVID-19 remains a significant public health problem in New South Wales, Australia. Although the NSW government is employing various control policies, more specific and compelling interventions are needed to control the spread of COVID-19. This paper presents a modified SEIR-X model based on a nonlinear ordinary differential equations system that considers the transmission routes from asymptomatic (Exposed) and symptomatic (Mild and Critical) individuals. The model is fitted to the corresponding cumulative number of cases in metropolitan and rural health districts of NSW reported by the Health Department and parameterised using the least-squares method. The basic reproduction number $$({\mathrm{R}}_{0})$$

(

R
0

)

, which measures the possible spread of COVID-19 in a population, is computed using the next generation operator method. Sensitivity analysis of the model parameters reveals that the transmission rate had an enormous influence on $${\mathrm{R}}_{0}$$

R
0

, which may be an option for controlling this disease. Two time-dependent control strategies, namely preventive (it refers to effort at inhibiting the virus transmission and prevention of case development from Exposed, Mild, Critical, Non-hospitalised and Hospitalised population) and management (it refers to enhance the management of Non-hospitalised and Hospitalised individuals who are infected by COVID-19) measures, are considered to mitigate this disease’s dynamics using Pontryagin’s maximum principle. The most sensible control strategy is determined through the cost-effectiveness analysis for the metropolitan and rural health districts of NSW. Our findings suggest that of the single intervention strategies, enhanced preventive strategy is more cost-effective than management control strategy, as it promptly reduces COVID-19 cases in NSW. In addition, combining preventive and management interventions simultaneously is found to be the most cost-effective. Alternative policies can be implemented to control COVID-19 depending on the policymakers’ decisions. Numerical simulations of the overall system are performed to demonstrate the theoretical outcomes.
Outcomes of professional development activities for selected Texas school personnel helping students cope with behavioral and mental health issues
Authors: Wingenbach Gary , Koswatta Taniya J. , Engels Josephine , Freeny Jamie , Haddad Sana
Published: June 2023

School personnel help youth cope with life and school stressors. However, help may depend on each person’s confidence or knowledge of such issues. In 2019 and 2020, more than 13,800 Texas educators participated in Emotional Backpack Project (EBP) training to support youth coping with behavioral and mental health issues. Post-intervention results revealed significant gains in self-perceived understanding of students’ behavioral and mental health issues, improved confidence in approaching students, parents, or other school staff to discuss students’ harmful behaviors, understanding of mindfulness activities, and increased knowledge of trauma informed schools and trauma informed educators. Teachers and other school personnel were less confident in approaching parents or guardians to discuss youth mental health issues than in approaching students, counselors, and other staff. School personnel’s knowledge, perceptions, and confidence to help students cope with behavioral and mental health issues was significantly better after EBP interventions. EBP training should be adopted widely and occur more than once annually.
Effectiveness of a probiotic combination on the neurodevelopment of the very premature infant
Authors: Baucells Benjamin James , Sebastiani Giorgia , Herrero-Aizpurua Leyre , Andreu-Fernández Vicente , Navarro-Tapia Elisabet , García-Algar Oscar , Figueras-Aloy Josep
Published: June 2023

Probiotics have shown a benefit in reducing necrotising enterocolitis in the premature infant, however the study of their effect on premature neonates’ neurodevelopment is limited. The aim of our study was to elucidate whether the effect of Bifidobacterium bifidum NCDO 2203 combined with Lactobacillus acidophilus NCDO 1748 could positively impact the neurodevelopment of the preterm neonates. Quasi-experimental comparative study with a combined treatment of probiotics in premature infants < 32 weeks and < 1500 g birth weight, cared for at a level III neonatal unit. The probiotic combination was administered orally to neonates surviving beyond 7 days of life, until 34 weeks postmenstrual age or discharge. Globally, neurodevelopment was evaluated at 24 months corrected age. A total of 233 neonates were recruited, 109 in the probiotic group and 124 in the non-probiotic group. In those neonates receiving probiotics, there was a significant reduction in neurodevelopment impairment at 2 years of age RR 0.30 [0.16–0.58], and a reduction in the degree of impairment (normal-mild vs moderate-severe, RR 0.22 [0.07–0.73]). Additionally, there was a significant reduction in late-onset sepsis (RR 0.45 [0.21–0.99]). The prophylactic use of this probiotic combination contributed to improving neurodevelopmental outcome and reduced sepsis in neonates born at < 32 weeks and < 1500 g.
Fetal sex and risk of pregnancy-associated malaria in Plasmodium falciparum-endemic regions: a meta-analysis
Authors: Unger Holger W. , Hadiprodjo Anastasia Jessica , Gutman Julie R. , Briand Valerie , Fievet Nadine , Valea Innocent , Tinto Halidou , D’Alessandro Umberto , Landis Sarah H. , Ter Kuile Feiko , Ouma Peter , Oneko Martina , Mwapasa Victor , Slutsker Laurence , Terlouw Dianne J. , Kariuki Simon , Ayisi John , Nahlen Bernard , Desai Meghna , Madanitsa Mwayi , Kalilani-Phiri Linda , Ashorn Per , Maleta Kenneth , Tshefu-Kitoto Antoinette , Mueller Ivo , Stanisic Danielle , Cates Jordan , Van Eijk Anna Maria , Ome-Kaius Maria , Aitken Elizabeth H. , Rogerson Stephen J.
Published: June 2023

In areas of moderate to intense Plasmodium falciparum transmission, malaria in pregnancy remains a significant cause of low birth weight, stillbirth, and severe anaemia. Previously, fetal sex has been identified to modify the risks of maternal asthma, pre-eclampsia, and gestational diabetes. One study demonstrated increased risk of placental malaria in women carrying a female fetus. We investigated the association between fetal sex and malaria in pregnancy in 11 pregnancy studies conducted in sub-Saharan African countries and Papua New Guinea through meta-analysis using log binomial regression fitted to a random-effects model. Malaria infection during pregnancy and delivery was assessed using light microscopy, polymerase chain reaction, and histology. Five studies were observational studies and six were randomised controlled trials. Studies varied in terms of gravidity, gestational age at antenatal enrolment and bed net use. Presence of a female fetus was associated with malaria infection at enrolment by light microscopy (risk ratio 1.14 [95% confidence interval 1.04, 1.24]; P = 0.003; n = 11,729). Fetal sex did not associate with malaria infection when other time points or diagnostic methods were used. There is limited evidence that fetal sex influences the risk of malaria infection in pregnancy.