bluuebunny/crossref_metadata_2025 huggingface dataset:
Effectiveness of Organic Waste Material Noise Dampening in Minimizing Noise Levels in Animal Feed Industry Machinery
Authors: Rinawati Seviana , Bolet Atmojo Tutug , Saptati A.S. Dwi , Ciptadi Gatot
Published: November 2023

Animal feed production machine specially in pellet machine to produce cylindrical animal feed, there is a pressing screw which high noise intensity. The industry has production machinery with high noise exposure and organic waste that can function as noise damping material. The aims of study to determine the effectiveness of noise absorbers from organic materials on machines. Methods of research is experimental. The object used the production machinery that will be intervened with organic damper on machines then measured by instruments: Sound Level Meter (noise intensity) and ArcGis 10.3 application for noise mapping areas. Analysis of research data with Wilcoxon test. The results showed that the noise intensity of machines exceeded the threshold limited value, an average of 96,75 and 97,35 dBA per 8 hours/day with the most red color zones. After using noise dampers, the noise intensity on the machine decreased to an average of 84,85 and 85,25 dBA/8 hours/day with the most green color zones. Statistical test results with a p-value of 0.000 show that there is a difference before and after the application of noise absorbers on machines. This study shows the effectiveness of organic waste material noise absorbers in minimizing noise levels in animal feed industry machinery.
Utilization of Biopori Infiltration Holes as a medium for composting in Purwoyoso Village Semarang City
Authors: Sumartono Agus , Wasiq Hidayat Jafron , Rahadian Rully
Published: November 2023

Population growth is directly proportional to the amount of waste produced. Facts on the ground show that almost 70% of the waste generated by households is organic waste. Organic waste is waste that comes from the remains of living things that easily decomposes naturally without human intervention to decompose and be processed again into compost. Utilization of biopore infiltration holes is used as a medium for composting organic waste. Compost sample testing methods to determine compost specifications include C-Organic testing using the Walkley & Black method; The N-Total test used the Wet Destruction + Indophenol method; Phosphate test using the wet destruction method + Ascorbic Acid; Testing for Potassium with the Wet Destruction+AAS method; pH measurement with a pH meter; testing the water content through a Moisture Analyzer and measuring the C/N ratio with a Gravimetric tool. The results obtained showed that only the water content and pH met the compost specifications based on SNI19-7030-2004. Other parameters indicate that the value of C-Organic, low Phosphate and C/N ratio that is too high indicates the composting process is too fast. So that potassium is of low value.
Analysis of Soil Absorption Capacity of Rainwater in Biopori Infiltration Holes in Purwoyoso Village Semarang City
Authors: Sumartono Agus , Hidayat Jafron Wasiq , Rahadian Rully
Published: November 2023

Drought and floods that hit Semarang City were caused by problems with water distribution and capacity. The ongoing conversion of land functions in the city of Semarang has resulted in reduced green open space and increased building density. This resulted in reduced infiltration of rainwater so that surface water runoff increased. Thus, causing a flood disaster that hit the city of Semarang in 2022, in which 7 out of 16 sub-districts were affected. This condition is exacerbated when rainfall is high and causes stagnant water because the existing drainage system is not optimal. The application of biopore infiltration holes in an effort to expand the rainwater infiltration area is a form of defense that can be carried out by the people of Semarang City in minimizing the occurrence of floods and groundwater crises. This study aims to analyze the absorption capacity of soil against rainwater in biopori infiltration holes in Purwoyoso Village. The method used is the Constant Head and Falling Head tests. The results of the groundwater absorption test showed that in sample B.1. and B.2. are 8.976.E-05 cm/sec and 9.488.E-05 cm/sec respectively. These results indicate that the absorption capacity of the soil in the biopori infiltration holes for rainwater is low or lacking.
Effect of Variation of Eco-Enzyme Addition on Macro Nutrient Content of Compost with Biopore Infiltration Holes
Authors: Sarminingsih Anik , Sumiyati Sri , Syafrudin  , Andika Axelino Farrell , Balqis Multika
Published: November 2023

The waste problem is increasing every year. Organic waste has the largest percentage of all types of waste. Research is needed to process organic waste in a shorter time. Eco-enzyme bioactivators are an alternative to speed up the processing of organic waste into compost. One of the composting media is Biopore Infiltration Holes. This study aims to analyze the effect of adding eco-enzyme to the content of macro nutrients (C,N,P,K) in the compost produced. The stages of this research included preparing tools and materials, loading organic waste into the Biopori Infiltration Holes, determining eco-enzyme dosing scenarios and observing time as well as testing the compost's macro nutrient content. The results of laboratory tests showed that there was an effect of adding eco-enzyme concentrations to the macro nutrient content of the compost. In general, the higher the dose of eco-enzyme, the macro nutrient content in the compost also increases.
Biomedical waste during the covid-19 pandemic in Indonesia: Systematic literature review
Authors: Kurnia Setiawan Limijadi Edward , Setio Devi Katrin
Published: November 2023

Since the beginning of the Coronavirus Disease 2019 (COVID-19) outbreak, there has been a significant increase in the quantity of hazardous biomedical waste, which poses a risk to human health and has a negative impact on the environment. There have been no specific studies conducted in Indonesia to assess the potential impact of biomedical waste during the pandemic COVID-19. Therefore, the purpose of this systematic review is to describe the various types of biomedical waste, their implications for health and the environment, as well as the techniques for managing biomedical waste during this pandemic. A total of 141 scientific articles were identified through the Google Scholar database. From these, 17 selected references were systematically analysed. The majority of the studies focused on investigating the environmental impacts of medical waste caused by the COVID-19 pandemic. From the 17 articles, we identified 7 articles that discussed the environmental hazards of biomedical waste, and 4 articles related to health. 6 articles outlined biomedical waste management (BWM) in Indonesia and solutions to implementation issues in BWM. It is recommended to conduct more studies, including meta-analyses, to gain a better understanding of the effects of medical waste on environmental health during the COVID-19 pandemic.
Concept of Waste Management in The Abrasion Puddle Area
Authors: Khoirul Anas Adib , Maryono Maryono , Purnaweni Hartuti
Published: November 2023

Waste management is very important to do considering that waste generation every day is increasing so that it can handle and reduce waste. The concept framework of waste management involves the community for empowerment. Community empowerment in this case is to make the community have the power to be able to manage waste so that it becomes something useful and even worth selling. Each region, district, city, and province already have waste management regulations for the targets and activities carried out by stakeholders should synergize sustainable development to promote an environmentally friendly waste management system and provide benefits for all. As a form of sustainable development, Sustainable Development Goals (SDGs) are developments that maintain the quality of the environment and development that ensures justice and the implementation of governance that can maintain the improvement of the quality of life from one generation to the next
Water Footprint of Constructed Wetlands – Lutopecny Case Study
Authors: Ansorge Libor , Stejskalová Lada , Rozkošný Miloš , Dočkal Martin
Published: November 2023

Constructed wetlands (CWs) are effective low-cost applications of nature-based solutions to the treatment of wastewater from small municipalities and isolated dwellings. One type of evaluation of CWs is focused on the effectiveness of wastewater treatment. Another type of CWs evaluation is focused on water balance because wetland plants are adapted to growth in conditions of unlimited water availability, which is associated with a high rate of evapotranspiration. In this study, the water footprint (WF) was used for joining these two evaluations. The blue WF describes water loss from CWs. The grey WF is an indicator of the effectiveness of CW in terms of pollution reduction. This is the first study of CWs that compares the importance of blue and grey WF under different climatic conditions during the year. Data from different seasons were used to calculate the WF of the CW in a temperate climate zone. During cold days, the grey WF is several times higher than the blue WF. Another situation occurs on hot summer days when the blue WF is higher than the grey WF. On all assessed days, the grey WF reduction was higher than the blue WF reduction; it means that the CW saves more clean water in the recipient (needed to dilute discharged pollution) than losses by evapotranspiration.
Evaluation of Community Development for Fishermen in Tanjung Limau, Bontang, Indonesia
Authors: Ekowati Sri Djuwani , Hadi Sudharto P. , Sasongko Dwi P. , Purnaweni Hartuti , Wijaya Anggono
Published: November 2023

Many people who live in the coastal area of Tanjung Limau in Bontang work as fishermen which is not environmentally friendly (Hadi,2019). Their lives depend on the weather at sea and they cannot go to the sea and catch fish every day. In order to support their lives, they have to owe money from middlemen which is paid by selling the fish they get from the sea to the middlemen with low price so they have to owe money to middlemen. Tanjung Limau is an area which is affected to the business activities of PKT. This is the reason why PKT implements CSR Program of grouper fish and lobsters on floating net cages in Tanjung Limau. PKT prepares the tools and infrastructure of cultivation along with the lobsters and grouper fish seeds, program implementation assistance, capacity improvement and market access. The research method applied in this research is qualitative method with narrative type and the data collection is performed through interview, observation, and document study. The data source sample was selected purposively and snowball sampling. The result from the CSR program of PKT is the fishermen in Tanjung Limau is free from debt from middlemen, they have access to international markets, they become independent with this sustainable program and they can share profit with PKT with the share ratio of 1: 1 when PKT provides the seeds of grouper fish. With the profit share between PKT and Koperasi Nelayan Bontang Ekonomi dan Pariwisata Maritim, thus this PKT CSR Program is considered to exceed the traditional CSR program but this program has not fulfilled the elements of Creating Shared Value (CSV), therefore it is called CSR plus (CSR+).
Critically Analysis The Practice Of Directed Community Development Of PT. Pupuk Kalimantan Timur, Bontang Indonesia
Authors: Ekowati Sri , Hadi Sudharto , Sasongko Dwi , Purnaweni Hartuti , Wijaya Anggono
Published: November 2023

In Tanjung Limau coastal community in Bontang City, some of the people make a living as fishing fishermen who are not environmentally friendly. Their lives depend on the weather at sea and cannot go to sea all day long. In order to sustain their life, they owe money to middlemen and are paid when they go to sea and get fish. The fish they get must be paid to the middlemen who give credit at low prices, so they are in debt to thr middlemen. Mr. Ismail, one of the leaders of the Fantasi group from the fishermen of Tanjung Limau, felt that his life was getting tougher, so he tried to cultivate grouper and lobster in the Fixed Net Cages (FxNC) and Floating Net Cages (FNC). His tenacity and patience made his business successful. PKT has the coastal CSR programs around its company; one of which is in Tanjung Limau forming a Creating Shared Value (CSV) Team to carry out the CSR program for grouper and lobster cultivation at the FNC in Tanjung Limau Bontang. At first, they collaborated with the Fantasi Group, and then it developed with several members of other fishing groups in North Bontang District joining. The capacity of fishermen was increased, assisted from the beginning of the program until the program ends and accompanied by access to export markets for the sale of live grouper fish because the price is more expensive. In addition, the program also involved them in planning so that it was successful and has even been replicated in three locations. The research method used was qualitative with the data collection techniques through interviews, observation and documentation studies as well as the type of narrative. The data source sample was selected purposively and snowball sampling. The comdev typology that emerged was a combination of imposed and self-help led to directed typology. The combination of the two brings the Tanjung Limau fishing community to be environmentally friendly, free from the entanglement of middlemen, empowered, independent and sustainable.
The Relationship Between Geological and Environmental Aspects with the Anomalies of Track Elements and Heavy Metal Elements in the Volcanic Area of the Muria Peninsula
Authors: Winarno Tri , Sendjaja Purnama , Rizaldy Wibowo Faris
Published: November 2023

The Muria Peninsula is a complex of volcanic activity located in the back arc of Sunda, which includes Kudus, Jepara, and surrounding districts. Volcanic activity on Mount Muria, can be used to study geological conditions, which were closely related to chemical elements. The presence of chemical elements in the river sediments of the Muria Peninsula was also influenced by anthropogenic heavy metal pollutants present in river deposits along the Muria Peninsula. The purpose of this study was to determine the relationship between the geological conditions and the environmental conditions of the Muria Peninsula with the anomaly of track elements and heavy metal elements. The methods used in this research were the pick test method, XRF geochemistry and the results were correlated into a geochemical anomaly map. The results showed that there were trace elements anomalies of Ce and Nd in Jepara area which were influenced by Muria shoshonitic rocks. Anomaly of Cu element was found in Jepara area, anomaly of Mn element was found in Jepara and Demak, and anomaly of Zn element was found in Jepara and Demak. Anomaly of Cu, M,n and Zn elements were high in upstream area and caused by land use of dry agriculture, paddy fields and settlement areas.
Small Wind Turbine base on PMSG for Battery Charger
Authors: Rizky Wahyu Yanuar , Setiawan Iwan , Handoko Susatyo
Published: November 2023

Nowadays, the use of renewable energy is growing and becoming a positive trend in the world. Wind energy being one of them. In the last few years, small power range capacity below 100 kW, being an option especially for small areas with low wind speeds. The application of PMSG-based wind turbines is becoming widespread among researchers because it has many advantages including high efficiency and low maintenance. In this study, the application of pmsg-based wind turbines is used for battery charging with the CCCV method. The charger will be tested with varying wind conditions.
Design of the Organic Rankine Cycle (ORC) System Using R600 and R600a as Working Fluid
Authors: Megaprastio Bayu , Zaka Ahmad Murtadlo , Zahra Rifda Salsabila , Aisyah Nyayu , Ariyadi Hifni Mukhtar
Published: November 2023

Organic Rankine Cycle (ORC) is one of the alternative technologies for generating electricity from low to medium level heat sources. ORC operates at low temperatures and pressures using two types of organic working fluids. The organic working fluids as the refrigerants were chosen in the ORC system instead of water, which is suitable for high pressure and temperature applications. Since the performance and configuration of the ORC system rely on its working fluids, the selection of the working fluid for the ORC system becomes crucial. The system utilizes low-temperature heat sources as a supply of heat energy that flows through the evaporator and is then received by the working fluid to operate the cycle. In this study, two dry type working fluids, namely butane (R600) and isobutane (R600a), were used to thermally design an ORC to recover geothermal waste heat. The working fluids were designed using mathematical calculations based on thermodynamic laws. The results revealed that a slightly higher thermal efficiency value was achieved when using R600 as the working fluid, which was 12.8% compared to R600a.
Early Detection Information System for Delayed Sputum Conversion Risk Factors
Authors: Wardani Dyah Wulan Sumekar Rengganis , Pramesona Bayu Anggileo , Septiana Trisya , Soemarwoto Retno Ariza Soeprihatini , Wahono Endro Prasetyo
Published: November 2023

Key indicators of tuberculosis control programs, two of them are success and cure rate. Moreover, to measure response to TB treatment, sputum conversion in the first two months is widely used. Low social determinants, presence of co-morbidities, medication nonadherence are risk factors that usually late identified and caused sputum conversion delay. This research aims to design an innovation early-detection system for sputum conversion risk factors in TB patients supported by an expert system. This research is operational research, involving all head of TB programs and head of primary health centres in Bandar Lampung, Indonesia. Research variables consist of social determinants and risk factors of sputum conversion delay. Method and data collection refer to first and second stage of system development life cycle. Results of focus group discussion obtain input and output system design. Input system design consists of risk factors list and yes or no answers choices based on TB patient’s examination. Meanwhile, output system design are expert recommendations based on input system. This information system provides both immediate detection as well as immediate expert recommendations, which will finally increase the chances of sputum conversion in the first two months of TB patient’s treatment.
Et si l’origine des progéniteurs fibro-adipeux contribuait à leur hétérogénéité dans le muscle ?
Authors: Mathieu Maxime , Girousse Amandine , Sengenès Coralie
Published: November 2023

Les progéniteurs fibro-adipogéniques (FAPs), cellules stromales mésenchymateuses (CSMs) résidentes du muscle squelettique, jouent un rôle crucial dans l’homéostasie et la régénération musculaire via leur activité paracrine. Les avancées technologiques récentes dans le domaine du séquençage de l’ARN en cellule unique ont permis la description de l’hétérogénéité de cette population cellulaire. Dans cet article, nous présenterons les différentes sous-populations de FAPs en condition basale, lésionnelle ou de dégénérescence, ainsi que leurs fonctions associées chez la souris et l’homme. Nous discuterons ensuite de l’origine extra-musculaire possible d’une population de FAPs post-lésionnelle. En effet, nos travaux récents démontrent que des CSMs provenant du tissu adipeux et infiltrées dans le muscle pourraient participer à l’hétérogénéité des FAPs.
Les omiques au service de la myologie
Authors: Simon Alix
Published: November 2023

Malgré les efforts de la recherche biomédicale, les mécanismes pathologiques et les cibles thérapeutiques des maladies restent difficiles à identifier. L’essor des technologies à haut débit a conduit au développement de technologies innovantes dites « omiques » (omics en langue anglaise). Elles visent à caractériser de manière exhaustive un ensemble de molécules : gènes, ARN, protéines, métabolites, etc. Ces méthodes sans a priori permettent une caractérisation moléculaire fine des maladies et une meilleure compréhension des mécanismes physiopathologiques complexes. Dans cet article, nous ferons un tour d’horizon des approches omiques, de leur intégration et de leurs applications dans le contexte de la myologie.
Sexualität und Gewalt: Normalitätskonstruktionen junger Menschen
Authors: Fixemer Tom , Henningsen Anja , Rusack Tanja , Tuider Elisabeth
Published: November 2023

Einleitung Ausgangspunkt des vorliegenden Beitrages ist, dass sowohl Fachdebatten als auch gesellschaftlichen Diskursivierungen zu sexualisierter Gewalt gewisse Narrationen, im Sinne von Mythen, über Sexualität eingeschrieben sind, und gleichzeitig die Sichtweisen junger Menschen auf Gewalt und Sexualität kaum eingeholt werden.

Forschungsziele Ziel dieses Beitrags ist es, aktuell bestehende Normalitätskonstruktionen junger Menschen zu Sexualität und sexualisierter Gewalt im Kontrast zu diskursiven Mythenkonstruktionen zu thematisieren.

Methoden Dem Beitrag liegen Forschungen zweier vom Bundesministerium für Bildung und Forschung (BMBF) geförderter Verbundprojekte zugrunde („Safer Places“ 2013–2016, „SchutzNorm“ 2018–2021). Mittels erzählgenerierender Interviews (n = 30 aus „Safer Places“ und n = 38 aus „SchutzNorm“) und zweier nicht-repräsentativer Onlinebefragungen (n = 364 aus „Safer Places“ und n = 1221 aus „SchutzNorm“) werden Normalitätskonstruktionen junger Menschen in Bezug auf Sexualität und Gewalt analysiert und mit hegemonialen Narrationen im Sinne von „Mythen des Alltags“ kontrastiert.

Ergebnisse Im Sexualitätsverständnis der befragten jungen Menschen ist eine Zustimmungsmoral zentral. Diese markiert die Abgrenzung zu sexualisierten Grenzüberschreitungen und Gewalt. Eine Vielfalt von Sexualität und Geschlecht ist ebenso wie ein differenziertes Gewaltverständnis sichtbar; körperliche sowie digitale Gewalt werden vordergründig als Verletzung persönlicher Grenzen benannt. Organisationaler Schutz wird nicht als Normalität wahrgenommen und sexualisierte Gewalt wird als Vergewaltigung und individuelles Problem verstanden. Selbstschuldzuweisungen bei Betroffenheit von sexualisierter Gewalt bestehen ebenso wie die Zurückweisung eines Opfer-Stigmas. Heteronormative Täter-Opfer-Bilder schreiben sich fort und Betroffenheiten von LGBTIQ*s werden übersehen.

Schlussfolgerung Normalitätskonstruktionen junger Menschen zu Sexualität, Gewalt und Schutz sind zukünftig als Ausgangslage in Schutzkonzeptentwicklungen und in den Fachdebatten zu berücksichtigen. Mythenkonstruktionen zu Sexualität und sexualisierter Gewalt von pädagogischen Fachkräften und jungen Menschen sind vertiefend in den forschenden Blick zu nehmen.
„Eine Win-win- Situation für alle Beteiligten“ – Kostenerstattungsverfahren
Authors: Mischner Julia
Published: November 2023

Im Interview berichtet die Ergotherapeutin und Praxisinhaberin Elke Kumar vom Kostenerstattungsverfahren. Es ermöglicht gesetzlich versicherten Patient*innen, Leistungen bei ihrer Krankenkasse abzurechnen, die eigentlich nur Privatversicherten zustehen. Ein Weg, vollen Wartelisten und dem Fachkräftemangel zu begegnen.
BF3@K10: An Efficient Heterogeneous Montmorillonite Catalyst for the Halogenation of N-Heterocycles
Authors: Lazrek Hassan B. , El Mansouri Az-eddine , Lachhab Saida , Mehdi Ahmad , Ait-Ali Mustapha , Sanghvi Yogesh S. , Zahouily M.
Published: November 2023

Halogenated N-heterocycles are an essential structural building block in medicinal chemistry. Herein, we describe an economical and efficient protocol for the regioselective halogenation of several N-heterocycles (pyrimidines, a pyrazole, 2-aminopyridine, theophylline, and an imidazo[1,2-a]pyridine) with BF3-doped montmorillonite (BF3@K10). The new catalyst was characterized by FTIR and 11B NMR spectroscopy, XRD, SEM, and EDS. The developed strategy provides easy and fast access to iodo-, bromo-, and chloro-N-heterocycles under mild conditions. This method was used to synthesize nine new halogenated pyrimidine derivatives. The reaction is simple and general, affording good to excellent yields of products under conventional heating or microwave conditions in the presence of BF3@K10 as an ecofriendly, inexpensive, and efficient catalyst. This protocol is clearly superior to the conventional route because it offers short reaction times, high yields, and easy workup.
Chronic Hand Eczema Treated with an Individualised Homoeopathic Ultradilution—A Case Report
Authors: Padigapati Dastagiri , Xavier Xinix
Published: November 2023

Eczema is a skin disease characterised by itching, redness, scaling and can be seen anywhere on the body, and the intensity of the complaints may vary individually. Hand eczema in the acute stage presents with macules, papules, vesicles and oedema; crusting, scaling, hyperkeratosis and fissure are the leading symptoms in the chronic stage if the complaints persist, lasting longer than 3 months or relapsing two or more times per year. However, it can also impact the patient's psychological health, as seen in the current case. Conventional treatment includes topical application and even steroids which can have long-term adverse effects and recurrence. A 48-year-old female presented with eczema on the palm, which had previously been treated by the conventional method. Petroleum 200c was prescribed after case taking and repertorisation, followed by Sulphur 200c as an antipsoric to prevent the recurrence of complaints. This case was followed up for 2 years with no recurrence of the complaints. It shows that the individualised medicine followed by miasmatic prescription will cure the disease. The relationship between treatment and clinical outcome is reaffirmed based on the Modified Naranjo Criteria for Homeopathy score 9, improvement in Dermatology Quality of Life Index and photographic evidence.
Reactivation of Tumor-like Chagas Disease in the Central Nervous System in Cardiac Transplant Patients: A Case Series and Literature Review
Authors: Prates Júnior Antônio Gilson , Macedo Fernando Augusto Medeiros Carrera , Malheiros José Augusto , Pinheiro Maria Letícia Marques , Souza Lucas Rodrigues de , Pinto Ana Luisa Ribeiro , Pohlmann Bruna Kelren Freitas
Published: November 2023

Introduction Chagas disease is an important public health problem in Latin American countries, affecting ∼ 6 million people within the region. In patients with chronic Chagas disease who undergo some type of immunosuppression reactivation of the acute form may occur, and manifestations involve many organs, including the central nervous system. Tumor-like brain reactivations are well described in patients with acquired immunodeficiency syndrome; however, this is a very rare event among Chagasic patients immunosuppressed after a heart transplantation.

Case Report We describe three cases of cardiac transplant patients who had a tumor-like intracranial lesion, whose biopsies were compatible with Chagas disease. All 3 patients were treated with benznidazole, and 2 of them presented parameters of cure after 60 days of treatment, while 1 required a 2nd cycle of treatment.

Discussion A tumor-like Chagas disease reactivation in the central nervous system may happen in heart-transplant patients and, due to the multiple differential diagnoses, we believe that brain biopsies should be considered when feasible.
Craniofacial Distraction Osteogenesis
Authors: Burns Heather R. , Wang Daniel S. , Abu-Ghname Amjed , Dempsey Robert F.
Published: November 2023

Distraction osteogenesis (DO) of the craniofacial skeleton has become an effective technique for the treatment of both nonsyndromic and syndromic conditions. The advent of craniofacial DO has allowed for earlier intervention in pediatric patients with less complication risk and morbidity compared to traditional techniques. In this review, we will discuss current application and technique for craniofacial DO by anatomical region and explore future applications in craniofacial surgery.
Pediatric Microsurgery and Free-Tissue Transfer
Authors: Burns Heather R. , Skochdopole Anna J. , Alfaro Zeledon Richardo , Pederson William C.
Published: November 2023

Advancements in microsurgery, along with increased microsurgical experience in pediatric patients, have made free-tissue transfer a reliable modality for pediatric bone and soft tissue reconstruction today. Free-tissue transfer is most commonly used in children for the coverage of large or complex defects resulting from traumatic, oncologic, or congenital etiologies. While flap success and complication rates between pediatric and adult populations are similar, special considerations must be taken into account within the pediatric population. In this article, we will describe common indications, technical nuances, and clinical considerations for the management of the pediatric free-tissue transfer patient.
Molecular Mimicry between Meningococcal B Factor H-Binding Protein and Human Proteins
Authors: Kanduc Darja
Published: November 2023

This study calls attention on molecular mimicry and the consequent autoimmune cross reactivity as the molecular mechanism that can cause adverse events following meningococcal B vaccination and warns against active immunizations based on entire antigen.
Exploring and understanding perceived relationships between doctoral students and their supervisors in China
Authors: Xu Yanru , Liu Ji’an
Published: November 2023

Fit in supervisory relationships is crucial for doctoral students’ outcomes, where supervisory relationships are influenced by cultural and disciplinary contexts. This article qualitatively explores fit or misfit between students’ perceptions and those of their supervisors on supervisory relationships in STEM in the cultural context of Chinese Confucianism. Considered through the lens of person-supervisor fit, two dimensions, consisting of four distinctions of supervisor-doctoral student fit or misfit in supervisory relationships, are identified: (1) a conceptual dimension consisting of supplementary fit or misfit; and (2) a practical dimension consisting of complementary fit or misfit. Supplementary fit is illustrated through three conceptual congruences regarding the nature of doctoral learning, students’ dispositions and the modelling and nurturing roles of supervisors. The term supplementary misfit refers to a conceptual incongruence regarding supervisors’ familial roles, which demonstrates contradictions between sustained cultural influences and the present-day academic profession. Complementary fit includes needs–supplies fit and demands–abilities fit, which bear disciplinary characteristics in modern STEM doctoral education. Complementary misfit refers to supervisors’ strict practices as against students’ demands for autonomy. This article advances the application of the person-supervisor fit perspective in STEM doctoral supervision and contributes to the understanding of disciplinary and cultural influences on the present-day academic supervisory relationships in China.
Loaded nanoparticles improve combination cancer treatments
Authors: Johnson-Groh Mara
Published: November 2023

Novel fabrication of specialized nanoparticles streamlines their use in phototherapy and chemotherapy treatments.
Effect of nanoparticles on piezoelectric response in polymer composites by quantitative evaluation
Authors: Wang Si-jiao , Yang Le , Chen Mengmeng
Published: November 2023

The effect of the intrinsic properties of silicone rubber and barium titanate (BaTiO3) nanoparticles on the piezoelectric properties of BaTiO3/silicon rubber composites was studied by the finite element analysis. The data of the simulation show that the stress and voltage of the composite were greatly increased when the concentration of the BaTiO3 nanoparticle increased from 5 to 30 vol. %. As Young’s modulus of silicone rubber increased from 5 to 20 MPa, the compressive stress of the composites raised linearly. With the Poisson’s ratio rising from 0.41 to 0.49, the compressive stress increased by 0.18 MPa in the process. When the dielectric constant of the BaTiO3/silicon rubber composite was less than 30, the potential difference of the piezoelectric film gradually raised with the dielectric constant increasing. When the dielectric constant of the composite was higher than 30, the output voltage of the composite gradually decreased. Therefore, the lower Young’s modulus and Poisson’s ratio of the silicone rubber composite is beneficial to improve the piezoelectric properties of the composite. This article will provide a reference for designing the preparation of spherical BaTiO3 composite materials.
Scalable and highly tunable conductive oxide interfaces
Authors: Cohen-Azarzar Dana , Baskin Maria , Lindblad Andreas , Trier Felix , Kornblum Lior
Published: November 2023

Conducting oxide interfaces have attracted considerable attention, motivated by both fundamental science and potential for oxide electronic devices. An important gap for maturing such device technology is scalability and routes to control the electronic properties, which can narrow the device engineering space. Here, we demonstrate and explain the mechanisms of highly tunable conductive oxide interfaces. We synthesized amorphous–crystalline Al2O3/SrTiO3 interfaces using the scalable and industry-compatible atomic layer deposition (ALD) technique. An NH3 plasma pretreatment is employed in the ALD chamber, and its duration is used as a tuning parameter for the electrical properties, where a span of three orders of magnitude in the sheet resistance is observed at room temperature. For the most conductive sample, our results are comparable to the highest carrier density values reported for all-crystalline oxide interfaces prepared with state-of-the-art epitaxial growth techniques, such as pulsed laser deposition. We pinpoint the origin of conductivity to oxygen vacancies caused by the SrTiO3 reduction by the NH3 plasma pretreatment. These results present a simple, scalable, and industry-compatible route for realizing conductive oxide interfaces, with a broad parameter space, offering a versatile and flexible toolkit for oxide device engineering.
Gastrointestinal infections after earthquake
Authors: Beşli Yeşim , Sancak Banu
Published: November 2023

Natural disasters such as earthquakes resulting in infrastructural damage in affected areas can also result in outbreaks of infectious diseases, with infections usually beginning within 4 days of the initial impact. Gastrointestinal diseases are prevalent due to the lack of food and water supplies. The rates of diarrheal illnesses following natural disasters are mainly influenced by the (i) endemicity of intestinal pathogens before the disaster, (ii) the availability of safe water and sanitation facilities, (iii) the severity of the disaster, (iv) the degree of crowding and (v) the availability of healthcare resources. Among the causative agents of gastroenteritis, viral infections are the most common ones, followed by bacterial and parasitic infections. Maintenance of sanitation and availability of primary healthcare are critical for early diagnosis, treatment and prevention of infectious disease outbreaks following natural disasters.
Cultural conceptualizations of sight and cultural values
Authors: Baranyiné Kóczy Judit
Published: November 2023

The relationship between visual experience and cognition manifested in thethinking/knowing/understanding is seeingmetaphor, is claimed to be the primary vision metaphor in various languages. However, only a few studies considered its extension to less central domains such ascultural values. The paper seeks to understand how the figurative usages of Hungarian vision verbs refer to the cultural values ofmorality,respect, andhospitality. Three verbs of vision are invesitaged employing Cultural Linguistic and cognitive semantic analyses, namely,néz‘look/watch’,lát‘see’, andtekint‘look/glance’. It is demonstrated that visual perception in Hungarian has a significant role in moral reasoning; however, there are substantial differences in the ways these vision verbs relate to them. To find a motivational explanation for these differences, the semantic properties of the verbs are identified through contrastive analysis and by observing their semantic profiles within thevisionscenario. As a result, a cultural model of each verb is reconstructed. The study gives a refined view on the linkage ofsightandcultural valuesin Hungarian, furthermore, the proposed methodology can be effectively applied to various areas of perception research in a cultural context.
Rethinking basic taste terms
Authors: Luo Yongxian
Published: November 2023

The general consensus about four basic tastes, sweet,
bitter, sour and salty, is rooted in Aristotle’s
writings. This inventory was expanded with the addition of
umami (or savoury) in the early years of last century, a
taste that wasn’t fully scientifically recognized until the mid-1980s. Work on
this area of human cognition from various fields – psychology, physiology,
chemistry and particularly food science – has led to new discoveries that allow
us to have a better understanding of the mechanism of taste. However, linguistic
work on this aspect of human perception is lacking. Questions remain to be asked
as to the size of the vocabulary of basic tastes, and how language can reflect
the organization of the taste domain. This paper proposes to look at basic
tastes by examining Chinese historical texts with an aim to reveal how the
ancient Chinese people classified and categorized tastes. It will be
demonstrated that the Chinese concept of “taste” boasts a long history, going
back to pre-historic times. The word for “taste”, 味 wèi, can also refer to “smell;
flavour.” The term is primarily used as a category noun, which gets borrowed
into Japanese to become the head element
-mi
of
the compound word umami in Japanese. Significantly, a form with
a similar sound shape, 美 měi, was found in ancient Chinese
with the meaning “tasty”, an adjective describing the taste, flavour of fresh
meat, akin to “savoury.” This indicates that we are dealing with a morphological
process or doublet in this semantic field. It also indicates that the idea of
“good taste, tasty, savoury” existed long before that of umami.
Equally important is the form with related meaning, 鲜 xiān, which is made up of two
graphic forms, “fish” （鱼） + “lamb” （羊）. This form etymologically denotes the
flavour of fresh fish, now carrying the sense of “fresh, delicious, tasty,
savoury” in Chinese, which further illustrates the point. Still another form,
旨 zhǐ “(n) good flavour; pleasant
taste,” is the source of the meaning of umami, as defined in
Japanese dictionaries. Several other tastes are also analysed. Their
implications for the expansion of basic tastes are discussed. The connections
between the taste domain and olfaction domain are explored, with insights from
some neighbouring languages.
Spherical seepage model of Bingham fluid in rough and low-permeability porous media
Authors: Yang Shanshan , Zhao Ke , Zheng Sheng
Published: November 2023

Based on the microstructure of porous media that exhibits statistical self-similarity fractal features, this paper investigates the radial flow characteristics of non-Newtonian fluids within rough porous media. The analytical equation of permeability and starting pressure gradient of Bingham fluid in low permeability rough porous media are established. It is found that the relative roughness is inversely proportional to the permeability and proportional to the starting pressure gradient. In addition, it is also found that the permeability of low permeability porous media decreases spherically with the increase of radial distance and curvature fractal dimension, and increases with the increase of pore area fractal dimension and porosity. Furthermore, the staring pressure gradient is directly proportional to the radial distance, yield stress and curvature fractal dimension. By comparing the model in this paper with the existing experimental data, the correctness and rationality of the spherical seepage fractal model are effectively verified.
Effect of laser welding and laser wire filling on forming and properties of dissimilar steel welded joints
Authors: Lina Sun , You Lu , Junxiang Jiang
Published: November 2023

In order to study the effects of different welding methods and different butt gaps on the microstructure and properties of welded joints of steel with unequal thickness, the medium carbon steel of 2 mm 50CrV and low carbon steel of 6 mm SPHE were used as test materials, and the welding was carried out by single laser and laser wire filling welding. The results show that the laser wire filling welding can reduce the welding cracks, and with the increase of the butt gap, the melt height gradually decreases, and the weld morphology transitions from Y shape to H shape. With the increase of the butt gap, the weld defects form. The hardness of weld center decreases with the increase of butt gap. The average hardness of weld formed by laser welding alone is the highest, and the highest hardness of welded joint is located in the heat affected zone of 50CrV medium carbon steel. The tensile strength of welded joints first increases and then decreases with the increase of butt gaps. When the butt gap is 0.6 mm, the surface morphology is good and the tensile strength is the highest. The fracture position of the welding test is on the side of the 2 mm 50CrV medium carbon steel.
A fringe jump counting method for the phase measurement in the HCN laser interferometer on EAST and its FPGA-based implementation
Authors: YAO 姚 Yuan 远 , YANG 杨 Yao 曜 , TI 提 Ang 昂 , SONG 宋 Yang 扬 , ZHANG 张 Jiamin 家敏 , WANG 王 Yan 琰 , ZHANG 张 Yao 耀 , LIU 刘 Haiqing 海庆 , JIE 揭 Yinxian 银先
Published: November 2023

Electron density in fusion plasma is usually diagnosed using laser-aided interferometers. The phase difference signal obtained after phase demodulation is wrapped, which is also called a fringe jump. A method has been developed to unwrap the phase difference signal in real time using FPGA, specifically designed to handle fringe jumps in the hydrogen cyanide (HCN) laser interferometer on the EAST superconducting tokamak. This method is designed for a phase demodulator using the fast Fourier transform (FFT) method at the front end. The method is better adapted for hardware implementation compared to complex mathematical analysis algorithms, such as field programmable gate array (FPGA). It has been applied to process the phase measurement results of the HCN laser interferometer on EAST in real time. Electron density results show good confidence in the fringe jump unwrapping method. Further possible application in other laser interferometers, such as the POlarimeter-INTerferometer (POINT) system on EAST tokamak is also discussed.
Hydrogen production through electrolysis and power generation through the fuel cell: an experimental and computational fluid dynamics study
Authors: Srinivas T , Subramanian Akhilesh , Reddy K Sreethan , Srinivas G
Published: November 2023

The most prevalent element found in nature is hydrogen. It functions as fuel that could be used in cells or as automotive fuel when it is in the diatomic state rather than just a gas. There are many ways to produce hydrogen, and the current effort focuses on one of them: producing hydrogen using electrolysis. The present study aims to determine the influence of various parameters such as electrode length, electrode diameter, electrode material, electrolyte concentration, and volume of the electrolyzer. The amount of hydrogen produced by the various compositions has been contrasted. The hydrogen yield has been found to be increase with increases in the electrolyte concentration and electrode length, but it has been found to be decrease with increases in electrode diameter. The graphite electrode has produced higher yield than the stainless steel electrode. The hydrogen produced by the system had been utilized as a source for the fuel cell module in the simulation tests, and it showed that the hydrogen electrolysis integrated with the fuel cell module may be able to generate power.
Considerations and limitations of buprenorphine prescribing for opioid use disorder in the intensive care unit setting: A narrative review
Authors: Erstad Brian L , Glenn Melody J
Published: November 2023

Purpose

The purpose of this review is to discuss important considerations when prescribing buprenorphine for opioid use disorder (OUD) in the intensive care unit (ICU) setting, recognizing the challenges of providing detailed recommendations in the setting of limited available evidence.

Buprenorphine is a partial mu-opioid receptor agonist that is likely to be increasingly prescribed for OUD in the ICU setting due to the relaxation of prescribing regulations. The pharmacology and pharmacokinetics of buprenorphine are complicated by the availability of several formulations that can be given by different administration routes. There is no single optimal dosing strategy for buprenorphine induction, with regimens ranging from very low-dose to high dose regimens. Faster induction with higher doses of buprenorphine has been studied and is frequently utilized in the emergency department. In patients admitted to the ICU who were receiving opioids either medically or illicitly, analgesia will not occur until their baseline opioid requirements are covered when their preadmission opioid is either reversed or interrupted. For patients in the ICU who are not on buprenorphine at the time of admission but have possible OUD, there are no validated tools to diagnose OUD or the severity of opioid withdrawal in critically ill patients unable to provide the subjective components of instruments validated in outpatient settings. When prescribing buprenorphine in the ICU, important issues to consider include dosing, monitoring, pain management, use of adjunctive medications, and considerations to transition to outpatient therapy. Ideally, addiction and pain management specialists would be available when buprenorphine is prescribed for critically ill patients.

Conclusion

There are unique challenges when prescribing buprenorphine for OUD in critically ill patients, regardless of whether they were receiving buprenorphine when admitted to the ICU setting for OUD or are under consideration for buprenorphine initiation. There is a critical need for more research in this area.
Extracellular vesicles modulate key signalling pathways in refractory wound healing
Authors: Yang Bowen , Lin Yumeng , Huang Yibo , Zhu Nanxi , Shen Ying-Qiang
Published: November 2023

Chronic wounds are wounds that cannot heal properly due to various factors, such as underlying diseases, infection or reinjury, and improper healing of skin wounds and ulcers can cause a serious economic burden. Numerous studies have shown that extracellular vesicles (EVs) derived from stem/progenitor cells promote wound healing, reduce scar formation and have significant advantages over traditional treatment methods. EVs are membranous particles that carry various bioactive molecules from their cellular origins, such as cytokines, nucleic acids, enzymes, lipids and proteins. EVs can mediate cell-to-cell communication and modulate various physiological processes, such as cell differentiation, angiogenesis, immune response and tissue remodelling. In this review, we summarize the recent advances in EV-based wound healing, focusing on the signalling pathways that are regulated by EVs and their cargos. We discuss how EVs derived from different types of stem/progenitor cells can promote wound healing and reduce scar formation by modulating the Wnt/β-catenin, phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin, vascular endothelial growth factor, transforming growth factor β and JAK–STAT pathways. Moreover, we also highlight the challenges and opportunities for engineering or modifying EVs to enhance their efficacy and specificity for wound healing.