bluuebunny/crossref_metadata_2025 huggingface dataset:
The structural wings of Matthew effects: The contribution of three-level network data to the analysis of cumulative advantage
Authors: Lazega Emmanuel , Jourda Marie-Thérèse
Published: March 2016

The article presents a three-level network approach to the Matthew effect as a multilevel complement to Burt’s (2005) conception of the relationship between networks and performance. We first introduce a three-level dataset and the specificity of this data structure for explorations of cumulative advantage. Second, we present a population of scientists and provide a heuristic visualization—as “paragliders”—of their position in this multilevel structure. Third, we cluster these actors into groups of performance to better understand who is in a multilevel position to make progress with performance measurements over time. We use Ronald Burt’s representation of the combined effect of brokerage beyond group and closure within group to show that several of these performance groups do not follow his own principles very closely. Fourth, we provide evidence, for one of these groups, of the usefulness of combining constraint in the personal network of its members with constraint in their “extended” network—that is, for looking at the relationship between performance and borrowing from “dual alters” in the extended network. This shows that, when it is present, network lift from three-level structural wings is provided by different levels for different actors. Hypotheses induced by the paraglider metaphor can thus be tested progressively to provide new understandings of the structural conditions under which the Matthew effect of cumulative advantage operates. Finally, we list limitations of this three-level approach to the Matthew effect as examined here and suggest further developments for this approach.
How Suitable Are Registry Data for Recurrence Risk Calculations? Validation of Diagnoses on 1,593 Families With Congenital Heart Disease
Authors: Ellesøe Sabrina Gade , Jensen Anders Boeck , Ängquist Lars Henrik , Hjortdal Vibeke Elisabeth , Larsen Lars Allan , Brunak Søren
Published: March 2016

Background:

Congenital heart disease (CHD) occurs in approximately 1% of all live births, and 3% to 8% of these have until now been considered familial cases, defined as the occurrence of two or more affected individuals in a family. The validity of CHD diagnoses in Danish administrative registry data has only been studied previously in highly selected patient populations. These studies identified high positive predictive values (PPVs) and recurrence risk ratios (RRRs—ratio between probabilities of CHD given family history of CHD and no family history). However, the RRR can be distorted if registry data are used indiscriminately. Here, we investigated the consequences of misclassifications for the RRR using validated diagnoses on Danish patients with familial CHD.

Methods:

Danish citizens are assigned a civil registration number (CPR number) at birth or immigration, which acts as a unique identifier in the Danish registries, thus enabling connection of information from several registries. Utilizing the CPR number, we identified Danish patients with familial CHD and reviewed each patient’s file. We compared diagnoses from the registries with those manually assigned, which enabled calculation of the PPVs of diagnoses in the Danish registries, and from this, we deduced the false discovery rate (FDR). To measure the consequences on the RRR, the FDR was applied to a simulated data set with true RRR values of 2 and 10.

Results:

We validated diagnoses of 2,442 patients from 1,593 families. Of these, 874 patients were misclassified corresponding to an FDR of 36%. Applying this FDR on the simulated data sets, we found that the RRR decreased from 2 and 10 to 1.4 and 5.1, respectively. Lastly, we estimated that 11% of all cases with CHD were familial.

Conclusion:

We found that approximately one of nine of all cases with CHD are familial, and we also found that 36% of individuals with CHD in administrative medical registries are misclassified, which distort the RRR in simulated scenarios.
Phenolic Composition and Evaluation of Methanol and Aqueous Extracts of Bitter Gourd (Momordica charantia L) Leaves on Angiotensin-I-Converting Enzyme and Some Pro-oxidant-Induced Lipid Peroxidation In Vitro
Authors: Shodehinde Sidiqat A. , Adefegha Stephen A. , Oboh Ganiyu , Oyeleye Sunday I. , Olasehinde Tosin A. , Nwanna Emmem E. , Adedayo Bukola C. , Boligon Aline A.
Published: March 2016

This study sought to assess the effects of bitter gourd leaf extracts (methanol and aqueous) on enzyme linked with hypertension (angiotensin-I-converting enzyme and some pro-oxidants (iron sulfate, sodium nitroprusside, and cisplatin]–induced lipid peroxidation in rat kidney homogenates. Chromatographic analysis of the extract was done using high-performance liquid chromatography–diode array detection. The results revealed that methanol extract (IC50 = 109.63 µg/mL) had significantly ( P < .05) higher angiotensin-I converting enzyme inhibitory activity than aqueous extract (IC50 = 182.95 µg/mL). Similarly, methanol extract had significantly ( P < .05) higher inhibitory effect on Fe2+- and cisplatin-induced lipid peroxidation than aqueous extract. However, there was no significant ( P > .05) difference in the inhibition of sodium nitroprusside–induced lipid peroxidation of both extracts. High-performance liquid chromatography–diode array detection analysis revealed the presence of quercetin, caffeic, gallic, and chlorogenic acids in the leaf. Thus, inhibition of angiotensin-I converting enzyme activity and the antioxidant properties of the extracts could be linked to the presence of phenolic phytochemicals.
Testing for association between RNA-Seq and high-dimensional data
Authors: Rauschenberger Armin , Jonker Marianne A. , van de Wiel Mark A. , Menezes Renée X.
Published: March 2016

Background

Testing for association between RNA-Seq and other genomic data is challenging due to high variability of the former and high dimensionality of the latter.

Results

Using the negative binomial distribution and a random-effects model, we develop an omnibus test that overcomes both difficulties. It may be conceptualised as a test of overall significance in regression analysis, where the response variable is overdispersed and the number of explanatory variables exceeds the sample size.

Conclusions

The proposed test can detect genetic and epigenetic alterations that affect gene expression. It can examine complex regulatory mechanisms of gene expression. The R package globalSeq is available from Bioconductor.
Cutaneous stimulation at the ankle: a differential effect on proprioceptive postural control according to the participants' preferred sensory strategy
Authors: Pavailler Sébastien , Hintzy Frédérique , Horvais Nicolas , Forestier Nicolas
Published: March 2016

Background

Ankle movements can be partially encoded by cutaneous afferents. However, little is known about the central integration of these cutaneous signals, and whether individual differences exist in this integration. The aim of this study was to determine whether the effect of cutaneous stimulation at the ankle would differ depending on the participants' preferred sensory strategy appraised by relative proprioceptive weighting (RPw).

Methods

Forty‐seven active young individuals free of lower‐limb injury stood on a force platform either barefoot or wearing a custom‐designed bootee. Vibrations (60 Hz, 0.5 mm) were applied either to the peroneal tendons or to the lumbar paraspinal muscles.

Results

The barefoot RPw was strongly negatively correlated to the absolute change in RPw measured in the bootee condition (r = −0.81, P < 0.001). Participants were then grouped depending on their barefoot RPw value. The RPw was significantly higher in the bootee condition than in the barefoot condition only for participants with low barefoot RPw.

Conclusions

The external cutaneous stimulation given by the bootee increased the weight of ankle proprioceptive signals only for participants with low barefoot RPw. This result confirmed that optimization of the ankle proprioceptive signals provided by cutaneous afferent stimulation has a differential effect depending on the participants' preferred sensory strategy.
Algorithm-guided goal-directed haemodynamic therapy does not improve renal function after major abdominal surgery compared to good standard clinical care: a prospective randomised trial
Authors: Schmid Sebastian , Kapfer Barbara , Heim Markus , Bogdanski Ralph , Anetsberger Aida , Blobner Manfred , Jungwirth Bettina
Published: March 2016

Background

Acute kidney injury is a common complication after major surgery. In this study, we investigated whether an algorithm-guided goal-directed haemodynamic therapy (GDT) can improve renal outcome compared to good standard clinical care.

Methods

A total of 180 patients undergoing major abdominal surgery were prospectively and randomly assigned to one of two groups: in the GDT group, patients were treated with a GDT algorithm using transpulmonary thermodilution while standard care was applied to the control patients. Change in creatinine was studied as the primary end point, postoperative complications as well as 1-year mortality as secondary outcomes. Haemodynamics in GDT and control patients were compared calculating goal-achievement rates.

Results

Postoperative change in creatinine (18 ± 39 μmol/l (control) vs. 16 ± 42 μmol/l (GDT); mean difference (95 % confidence interval) 1.6 μmol/l (−10 to 13 μmol/l)) was comparable between the GDT and the control group. Postoperative complications and mortality during hospital stay and after 1 year were not influenced by the use of a GDT algorithm. Achievement rates of haemodynamic goals were not higher in the GDT group compared to the already high (>80 %) rates in the control group. Multivariate regression analysis revealed intraoperative hypotension (MAP < 70 mmHg) and postoperative hypovolaemia (GEDI < 640 ml/m2) as risk factors for postoperative renal impairment.

Conclusions

In this study, GDT was not superior to standard clinical care in order to avoid renal failure after major abdominal surgery. The reason for this finding is most likely the high achievement rate of haemodynamic goals in the control group, which cannot be improved by the GDT algorithm.

Trial registration

Clinicaltrials.gov; NCT01035541; registered 17 December 2009.
Convergence theorems for finite families of total asymptotically nonexpansive mappings in hyperbolic spaces
Authors: Ali Bashir
Published: March 2016

In this paper, using a multistep iterative scheme, we establish strong and Δ-convergence theorems for finite families of total asymptotically quasi-nonexpansive mappings in uniformly convex hyperbolic spaces. We then establish Δ- and polar convergence theorems for finite families of total asymptotically nonexpansive mappings in CAT(0) spaces. These new theorems are extensions, improvements, and generalizations of some recently announced results by many authors.
Post-hatching development of mitochondrial function, organ mass and metabolic rate in two ectotherms, the American alligator (Alligator mississippiensis) and the common snapping turtle (Chelydra serpentina)
Authors: Sirsat Sarah K. G. , Sirsat Tushar S. , Price Edwin R. , Dzialowski Edward M.
Published: March 2016

The ontogeny of endothermy in birds is associated with disproportionate growth of thermogenic organs and increased mitochondrial oxidative capacity. However, no similar study has been made of the development of these traits in ectotherms. For comparison, we therefore investigated the metabolism, growth and muscle mitochondrial function in hatchlings of a turtle and a crocodilian, two ectotherms that never develop endothermy. Metabolic rate did not increase substantially in either species by 30 days post-hatching. Yolk-free body mass and heart mass did not change through 30 days in alligators and heart mass was a constant proportion of body mass, even after 1 year. Yolk-free body mass and liver mass grew 36% and 27%, respectively, in turtles during the first 30 days post-hatch. The mass-specific oxidative phosphorylation capacity of mitochondria, assessed using permeabilized muscle fibers, increased by a non-significant 47% in alligator thigh and a non-significant 50% in turtle thigh over 30 days, but did not increase in the heart. This developmental trajectory of mitochondrial function is slower and shallower than that previously observed in ducks, which demonstrate a 90% increase in mass-specific oxidative phosphorylation capacity in thigh muscles over just a few days, a 60% increase in mass-specific oxidative phosphorylation capacity of the heart over a few days, and disproportionate growth of the heart and other organs. Our data thus support the hypothesis that these developmental changes in ducks represent mechanistic drivers for attaining endothermy.
Activation of a T-box-Otx2-Gsc gene network independent of TBP and TBP-related factors
Authors: Gazdag Emese , Jacobi Ulrike G. , van Kruijsbergen Ila , Weeks Daniel L. , Veenstra Gert Jan C.
Published: March 2016

The developmental program relies on activating and repressing regulatory influences which are faithfully integrated at the core promoter of individual genes. In vertebrates, the basal machinery recognizing the core promoter includes TATA binding protein (TBP) and two TBP-related factors. In Xenopus embryos the three TBP family factors are all essential for development and required for expression of distinct subsets of genes. Here we report on a non-canonical TBP family-insensitive (TFI) mechanism of transcription initiation that involves mesoderm and organizer gene expression. Using TBP family single and triple knockdown experiments, α-amanitin treatment, transcriptome profiling and chromatin immunoprecipitation, we found that TFI gene expression cannot be explained by functional redundancy, is supported by active transcription, and shows normal recruitment of the initiating form of RNA polymerase II to the promoter. Strikingly, recruitment of Gcn5 (Kat2a), a co-activator which has been implicated in transcription initiation, to TFI promoters is increased upon depletion of TBP family factors. TFI genes are part of a densely connected TBP family-insensitive T-box-Otx2-Gsc interaction network. The results indicate that this network of genes bound by Vegt, Eomes, Otx2 and Gsc utilizes a novel, flexible and non-canonical mechanism of transcription that does not require TBP or TBP-related factors.
Alpha-Spectrin and Integrins act together to regulate actomyosin and columnarization, and to maintain a mono-layered follicular epithelium
Authors: Ng Bing Fu , Selvaraj Gokul Kannan , Mateos Carmen Santa-Cruz , Grosheva Inna , Alvarez-Garcia Ines , Martín-Bermudo María Dolores , Palacios Isabel M.
Published: March 2016

The Spectrin cytoskeleton crosslinks actin to the membrane, and although it has been greatly studied in erythrocytes, much is unknown about its function in epithelia. We have studied the role of Spectrins during epithelia morphogenesis using the Drosophila follicular epithelium (FE). As previously described, we show that α-Spectrin and β-Spectrin are essential to maintain a mono-layered FE, but, contrary to previous work, Spectrins are not required to control proliferation. Furthermore, spectrin cells show differentiation and polarity defects only in the ectopic layers of stratified epithelia, similar to integrin mutants. Our results identify α-Spectrin and integrins as novel regulators of apical constriction-independent cell elongation, as α-spectrin and integrin cells fail to columnarize. Finally, we show that increasing and reducing the activity of the Rho1-myosin-II pathway enhances and decreases multi-layering of α-spectrin cells, respectively. Similarly, higher myosin-II activity enhances the integrin multi-layering phenotype. This work identifies a primary role for α-Spectrin in controlling cell shape, perhaps by modulating actomyosin. All together, we suggest that a functional Spectrin-Integrin complex is essential to balance adequate forces, in order to maintain a mono-layered epithelium.
Clarification of mural cell coverage of vascular endothelial cells by live imaging of zebrafish
Authors: Ando Koji , Fukuhara Shigetomo , Izumi Nanae , Nakajima Hiroyuki , Fukui Hajime , Kelsh Robert N. , Mochizuki Naoki
Published: March 2016

Mural cells (MCs) consisting of vascular smooth muscle cells and pericytes cover the endothelial cells (ECs) to regulate vascular stability and homeostasis. Here, we clarified the mechanism how MCs develop and cover ECs by generating the transgenic zebrafish lines that allow live imaging of MCs and by lineage tracing in vivo. To cover cranial vessels, MCs derived from either neural crest cells or mesoderm emerged around the preformed EC tubes, proliferated and migrated along EC tubes. During their migration, the MCs moved forward by extending their processes along the inter-EC junctions, suggesting the role of inter-EC junctions as a scaffold for MC migration. In the trunk vasculature, MCs derived from mesoderm covered the ventral side of the dorsal aorta (DA), but not the posterior cardinal vein. Furthermore, the MCs migrating from the DA or emerging around intersegmental vessels (ISV) preferentially covered arterial ISVs rather than venous ISVs, indicating that MCs mostly cover arteries during vascular development. Thus, live imaging and lineage tracing enabled us to precisely clarify how MCs cover the EC tubes and to identify the origins of MCs.
ΔΥΟ ΝΕΟ - ΑΤΤΙΚΑ ΗΜΙΕΡΓΑ ΣΤΟ ΕΘΝΙΚΟ ΜΟΥΣΕΙΟ
Authors: ΠΑΛΑΓΓΙΑ ΟΛΓΑ
Published: March 2016

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LA NAISSANC E DU NOUVEL ÉTAT GREC. VUE PAR LA PRESSE TOULOUSAINE ' (Période de 1821 à 1825)
Authors: PETALA ALEXANDRA V.
Published: March 2016

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ΠΟΛΙΤΕΙΑΚΑΙ ΜΕΤΑΒΟΛΑΙ ΤΩΝ ΡΟΔΙΩΝ ΑΠΟ TOY ΕΤΟΥΣ 404 π.Χ. ΜΕΧΡΙ ΤΟΥ ΕΤΟΥΣ 351 π.Χ.
Authors: PAMΟY - ΧΑΨΙAΔH AΝΝA
Published: March 2016

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ΑΞΙΩΜΑΤΟΥΧΟΙ ΣΤΗΝ ΑΥΛΗ ΤΟΥ ΑΛΗ ΠΑΣΑ
Authors: ΠΕΤΑΛΑ ΑΛΕΞΑΝΔΡΑ
Published: March 2016

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ΕΝΕΡΓΕΙΕΣ ΤΟΥ ΙΩΑΝΝΟΥ ΦΙΛΗΜΟΝΟΣ ΓΙΑ ΤΗΝ ΕΚΔΟΣΗ ΦΙΛΟΚΑΠΟΔΙΣΤΡΙΑΚΗΣ ΕΦΗΜΕΡΙΔΑΣ
Authors: ΚΑΤΗΦΟΡΗ ΔΕΣΠΟΙΝΑ
Published: March 2016

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Η ΟΙΚΟΝΟΜΙΚΗ ΚΡΙΣΗ ΣΤΟΝ ΕΛΛΑΔΙΚΟ ΧΩΡΟ ΣΤΙΣ ΑΡΧΕΣ ΤΟΥ 19ΟΥ ΑΙΩΝΑ ΚΑΙ ΟΙ ΕΠΙΠΤΩΣΕΙΣ ΤΗΣ ΣΤΗΝ ΕΠΑΝΑΣΤΑΣΗ ΤΟΥ 1821
Authors: ΚΡΕΜΜΥΔΑΣ ΒΑΣΙΛΗΣ
Published: March 2016

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ΑΝΕΚΔΟΤΕΣ ΕΠΙΣΤΟΛΕΣ ΤΟΥ ΜΙΧΑΗΛ ΟΙΚΟΝΟΜΟΥ ΚΑΙ ΤΟΥ ΘΕΟΚΛΗΤΟΥ ΦΑΡΜΑΚΙΔΗ (ΜΑΡΤ.-ΜΑΪΟΣ 1827)
Authors: ΑΓΓΕΛΟΜΑΤΗ - ΤΣΟΥΓΚΑΡΑΚΗ ΕΛΕΝΗ
Published: March 2016

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ΠΑΡΑΓΟΝΤΕΣ ΤΗΣ ΕΜΠΟΡΙΚΗΣ ΝΑΥΤΙΛΙΑΣ ΓΥΡΩ ΣΤΟ 1875
Authors: ΓΑΡΔΙΚΑ ΚΑΤΕΡΙΝΑ
Published: March 2016

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ΚΑΤΑΓΡΑΦΗ ΤΩΝ ΕΜΠΟΡΙΚΩΝ ΠΛΟΙΩΝ ΤΟΥ ΗΡΑΚΛΕΙΟΥ ΤΟ 1751
Authors: ΚΡΕΜΜΥΔΑΣ ΒΑΣΙΛΗΣ
Published: March 2016

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ΑΝΕΚΔΟΤΕΣ ΕΠΙΣΤΟΛΕΣ ΤΟΥ Γ. ΣΚΛΗΡΟΥ ΣΤΟΝ Γ. Ν. ΠΟΛΙΤΗ. Από τις «παλιές καλές μέρες της Ιένας» στην «ανίερον πραγματικότητα» της βιοπάλης στην Αίγυπτο
Authors: ΣΤΑΥΡΙΔΗ - ΠΑΤΡΙΚΙΟΥ ΡΕΝΑ
Published: March 2016

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ΧΕΙΡΟΓΡΑΦΑ ΦΟΥΡΝΑ ΕΥΡΥΤΑΝΙΑΣ
Authors: ΔΗΜΗΤΡΑΚΟΠΟΥΛΟΣ ΦΩΤΙΟΣ ΑΡ.
Published: March 2016

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ΛΗΣΤΕΣ ΚΑΙ ΛΗΣΤΑΝΤΑΡΤΕΣ ΣΤΗΝ ΚΕΝΤΡΙΚΗ ΕΛΛΑΔΑ ΤΟ 1835-1836
Authors: ΚΟΛΙΟΠΟΥΛΟΣ ΓΙΑΝΝΗΣ
Published: March 2016

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Ο ΡΗΓΑΣ ΦΕΡΑΙΟΣ. ΝΕΑ ΣΤΟΙΧΕΙΑ ΑΠΟ ΤΑ ΑΡΧΕΙΑ ΤΗΣ ΤΕΡΓΕΣΤΗΣ
Authors: ΚΑΤΣΙΑΡΔΗ ΟΛΓΑ
Published: March 2016

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ΣΥΓΚΡΙΤΙΣΜΟΣ
Authors: ΔΗΜΑΡΑΣ Κ. Θ.
Published: March 2016

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ΤΟ ΠΡΟΒΛΗΜΑ ΤΩΝ ΓΕΝΙΚΕΥΣΕΩΝ ΣΤΗΝ ΙΣΤΟΡΙΑ
Authors: ΠΡΕΒΕΛΑΚΗΣ ΕΛΕΥΘΕΡΙΟΣ
Published: March 2016

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ΙΣΟΚΡΑΤΟΥΣ ΛΟΓΟΙ ΤΡΕΙΣ: ΦΛΩΡΕΝΤΙΑ c. 1495 Ή ΡΩΜΗ c. 1517; ΓΥΡΩ ΑΠΟ ΜΙΑ ΔΙΟΡΘΩΣΗ ΣΤΟΝ LEGRAND
Authors: ΚΟΚΚΩΝΑΣ ΓΙΑΝΝΗΣ
Published: March 2016

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Η ΔΟΜΗ ΤΗΣ ΕΛΛΗΝΙΚΗΣ ΟΙΚΟΓΕΝΕΙΑΣ ΣΤΗ ΘΡΑΚΗ
Authors: ΑΛΕΞΑΚΗΣ ΕΛΕΥΘΕΡΙΟΣ Π.
Published: March 2016

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ΜΑΡΤΥΡΙΕΣ ΓΙΑ ΤΗΝ ΠΤΩΣΗ Τ' ΑΝΑΠΛΙΟΥ ΣΤΟΥΣ ΤΟΥΡΚΟΥΣ (9 ΙΟΥΛΗ 1715)
Authors: ΛΙΑΤΑ ΕΥΤΥΧΙΑ Δ.
Published: March 2016

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Η ΕΞΕΛΙΞΙΣ ΤΩΝ ΤΟΥΡΚΟΛΟΓΙΚΩΝ ΣΠΟΥΔΩΝ ΚΑΙ Η ΑΝΑΓΚΗ ΚΑΛΛΙΕΡΓΕΙΑΣ ΑΥΤΩΝ ΕΝ ΕΛΛΑΔΙ
Authors: ΓΙΑΝΝΟΠΟΥΛΟΣ ΙΩΑΝΝΗΣ Γ.
Published: March 2016

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Ο EMM. ΑΝΤΩΝΙΑΔΗΣ ΚΑΙ ΤΑ ΠΕΡΙ ΑΝΑΜΕΙΞΕΩΣ ΤΟΥ ΕΙΣ ΤΗΝ ΠΕΙΡΑΤΕΙΑΝ
Authors: ΚΑΤΗΦΟΡΗ ΔΕΣΠΟΙΝΑ
Published: March 2016

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ΑΝΕΚΔΟΤΑ ΕΓΓΡΑΦΑ ΠΕΡΙ ΤΗΣ ΜΟΝΗΣ ΤΑΞΙΑΡΧΩΝ ΑΙΓΙΟΥ
Authors: ΤΣΙΟΥΡΑΚΗ ΒΑΡΒΑΡΑ
Published: March 2016

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Shots Fired! Switching Between Practices in Police Work
Authors: Schakel Jan-Kees , van Fenema Paul C. , Faraj Samer
Published: March 2016

Fast-response organizations are under increased scrutiny as to their ability to mount a timely and coordinated response to unexpected events. Our inductive study focuses on a high profile murder that occurred in Amsterdam in 2011 where a large multidisciplinary police team faced major coordination challenges and was unsuccessful in switching from the practice of surveillance to that of apprehension when their target was suddenly gunned down. Our analysis suggests that challenges related to relational ambiguity, knowledge flows, communications technology, team composition, and field obstructions, hindered the switching between practices under conditions of surprise and fast response. The paper offers a theoretical framework toward a greater understanding of the persistent coordination challenges that arise when a sudden switch from one practice to another becomes necessary. Our study contributes toward a greater understanding of practice performance and the social and material challenges related to switching between practices.
Stability of the equilibrium points in the circular restricted four body problem with oblate primary and variable mass
Authors: Abduljabar Ansari Abdullah
Published: March 2016

This paper investigates the liberation points and stability of the restricted four body problem with one of the primaries as oblate body and the infinitesimal body is taken as variable mass. Due to oblateness, the equilateral triangular configuration is no longer exists and becomes an isosceles triangular configuration. Moreover, we have found seven equilibrium points out of which three are asymptotically stable (dark black in the tables) and rest four are unstable.
Response Letter to Editor: In response to The Letter to Editor by Dinçer (2016): Concerning “A content analysis and methodological evaluation of meta-analyses on Turkish samples”
"Türkiye örnekleminde meta analiz çalışmalarının içerik analizi ve metodolojik değerlendirilmesi" konusunda Dinçer (2016) "Editöre Mektup"a cevaben
Authors: Başol Gülşah
Published: March 2016

This letter was written in response to Dinçer (2016)’s letter in response to Başol, Doğuyurt and Demir (2016), published in the recent edition of International Journal of Human Sciences. First, the model selection approach followed in the studies by leading author were explained in detail, in order to make it clear that the model selection was not based on a statistical test as it was claimed in Dinçer’s letter.  The second part of the letter includes an explanation to the ethical concerns in the letter. ÖzetBu mektup, Uluslararası İnsan Bilimleri süreli yayınında yayımlanan Dinçer’e (2016) ait, Başol, Doğuyurt and Demir (2016) çalışmasına cevaben yazılmış olan editöre mektuba cevap niteliğindedir. Mektubun birinci bölümünde, Dinçer (2016)'da belirtilen, tarafımın dahil olduğu meta analiz çalışmalarında model seçiminde izlenilen yol açıklanmış; Dinçer (2016)'da bahsi geçtiği üzere hetorojenlik testine bağlı olarak model seçiminin çalışmalarımda söz konusu olmadığı ortaya konmuştur. Mektubun ikinci bölümünde, Dinçer (2016)’da dile getirilen etik kaygılara cevap verilmiştir.
On the Inf-Sup Constant of a Triangular Spectral Method for the Stokes Equations
Authors: Su Yanhui , Chen Lizhen , Li Xianjuan , Xu Chuanju
Published: March 2016

The Ladyženskaja–Babuška–Brezzi (LBB) condition is a necessary condition
for the well-posedness of discrete saddle point problems stemming from discretizing
the Stokes equations. In this paper, we prove the LBB condition and provide the (optimal) lower bound for this condition for the triangular spectral method proposed by L. Chen, J. Shen, and C. Xu in [3]. Then this lower bound is used to derive an error
estimate for the pressure. Some numerical examples are provided to confirm the theoretical estimates.
Performance Investigation of Membrane Process in Natural Gas sweeting by Membrane Process: Modeling Study
Authors: Ghasemzadeh Kamran , Jafari Mostafa , sari Amir , Babalou Ali A.
Published: March 2016

The main purpose of this work is the numerical investigation of PEBX membrane performance for natural gas sweeting. Hence, a single-stage process for PEBX membrane was considered in various flow patterns, namely, cocurrent, cross flow and countercurrent to separate a typical natural gas mixture. To this target, a black box numerical model was extended for the ASPEN HYSYS commercial package and also its validation was realized by litterature experimental data. The validation results indicated a good agreement between thoritical results and experimental data. After model validation, the effect of the some significant operating parameters (pressure gradient, stage cut and membrane area) on the performance of PEBX membrane was analysed in terms of acid gases removal percentage. The simulation results presented a noticeable performance of PEBX membrane to produce high purity CH4. In particular, concerning the stage cut effect, it was found that the CO2 and H2S compositions in the permeate side were decreased through the enhancment of stage cut from 0.005 to 0.03, whereas the CH4 composition increased for whole the flow patterns. Moreover, a similar effect was achived for membrane surface area. On the other hand, the transmembrane pressure effect was positive on the PEBX membrane performance during natural gas sweeting.
An analytical study of the endoreversible Curzon–Ahlborn cycle for a non-linear heat transfer law
Authors: Páez-Hernández Ricardo T. , Portillo-Díaz Pedro , Ladino-Luna Delfino , Ramírez-Rojas Alejandro , Pacheco-Paez Juan C.
Published: March 2016

In the present article,
an endoreversible Curzon–Ahlborn engine is studied by considering a non-linear heat transfer law, particularly the Dulong–Petit heat transfer law, using the `componendo and dividendo' rule as well as a simple differentiation to obtain the Curzon–Ahlborn efficiency as proposed by Agrawal in 2009. This rule is actually a change of variable that simplifies a two-variable problem to a one-variable problem. From elemental calculus, we obtain an analytical expression of efficiency and the power output. The efficiency is given only in terms of the temperatures of the reservoirs, such as both Carnot and Curzon–Ahlborn cycles. We make a comparison between efficiencies measured in real power plants and theoretical values from analytical expressions obtained in this article and others found in literature from several other authors. This comparison shows that the theoretical values of efficiency are close to real efficiency, and in some cases, they are exactly the same. Therefore, we can say that the Agrawal method is good in calculating thermal engine efficiencies approximately.
Assessment of selected health behaviors of women after breast cancer therapy
Authors: Prokopowicz Katarzyna , Prokopowicz Grzegorz , Molik Bartosz , Kozdroń Ewa
Published: March 2016

Introduction: Health is highly valued by individuals as well as whole social groups. Lifestyle, and related with this health behaviors are believed to be the main factors that largely determine its condition. Poland is a country, where the number of malignant cancer morbidity is systematically increasing. Breast cancer is the most common among women aged 45 years old. Despite the relative stability of the mortality outcomes the rate of it is still high. This situation is influenced by many factors, including the limited awareness of the value of health-related behaviors.

Material and methods: The study included 70 women aged 45-75 years old. The study and control group consisted of: 36 women with breast cancer and 34 women without cancer in history. The specifically developed questionnaire and the Positive Health Behaviors Scale for Women developed by Hildt-Ciupińska were used in this study. IBM SPSS v. 21.0 was used for statistical analysis and non-parametric U-Mann Whitney test.

Results: The study let determine the level of women's health behaviors. The analysis of the results showed that there are much anomalies in health-related behaviors in both studied groups. The lowest point scale values were reported in the "Physical activity" subscale. The highest values were reported in the "Safety behaviors" and "Caring body" subscale. The disappointing results in statements related with the prevention of cancer were the most alarmous.

Conclusions: The introduction of health prevention awareness programs in the group of women over 45 years of age, may contribute to an increase in the frequency of health-promoting behaviors.
Life cycle assessment of dairy farms
Authors: Taufiq Fierly Muhammad , Padmi Tri , Rahardyan dan Benno
Published: March 2016

In 2013 the population of dairy cattle in Indonesia had reached 636,000 head with a 4.61% growth rate per year. The inputs were energy, water, and feed. These inputs produced outputs, such as emissions, solid waste and liquid waste. This research compared the maintenance systems in modern farms and local farms. The data were collected from 30 local farmers and one modern farm. This research used the life cycle assessment (LCA) method. LCA is based on ISO 14040. LCA consists of several stages: the goal and scope definition, inventory analysis, impact assessment, and interpretation. This research used the cradle to gate concept and fat corrected milk (FCM) as the function unit. The impacts of these activities could generate global warming potential (GWP), acidification potential (AP), and eutrophication potential (EP). The calculations showed that the systems in local farms had the greatest emissions result over all impacts. In the case of local farms, the GWP was 2.34 kg CO2 eq/L of milk FCM, AP was 0.12 g SO2 eq/L of milk FCM, and EP was 18.28 g

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eq/L milk FCM. While the impact from the modern farm was GWP of 1.52 kg CO2 eq/L of milk FCM, AP of 0.02 g SO2 eq/L of milk FCM, and EP of 0.353 g

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eq/L of milk FCM. Based on the total-weighted result, the GWP had the greatest impact from the overall life cycle phase of milk production. The total-weighted result obtained was of 0.298 EUR/L of FCM from a local farm and 0.189 EUR/L of FCM from the modern farm. This amount could be used to remediate the global warming, acidification, and eutrophication impacts of milk production.
Protecting health from metal exposures in drinking water
Authors: Armour Margaret-Ann
Published: March 2016

Drinking water is essential to us as human beings. According to the World Health Organization “The quality of drinking-water is a powerful environmental determinant of health” (http://www.who.int/water_sanitation_health/dwq/en/), but clean drinking water is a precious commodity not always readily available. Surface and ground water are the major sources of drinking water. Both can be contaminated, surface water with bacteria while ground water frequently contains salts of metals that occur naturally or are introduced by human activity. This paper will briefly review the metallic salts found in drinking water in areas around the world, as well as list some of the methods used to reduce or remove them. It will then discuss our research on reducing the risk of pollution of drinking water by removal of metal ions from wastewater.
Prenatal cocaine exposure and its impact on cognitive functions of offspring: a pathophysiological insight
Authors: Gkioka Eleana , Korou Laskarina Maria , Daskalopoulou Afrodite , Misitzi Angelica , Batsidis Eleni , Bakoyiannis Ioannis , Pergialiotis Vasilios
Published: March 2016

It is estimated that approximately 0.5%–3% of fetuses are prenatally exposed to cocaine (COC). The neurodevelopmental implications of this exposure are numerous and include motor skill impairments, alterations of social function, predisposition to anxiety, and memory function and attention deficits; these implications are commonly observed in experimental studies and ultimately affect both learning and IQ. According to previous studies, the clinical manifestations of prenatal COC exposure seem to persist at least until adolescence. The pathophysiological cellular processes that underlie these impairments include dysfunctional myelination, disrupted dendritic architecture, and synaptic alterations. On a molecular level, various neurotransmitters such as serotonin, dopamine, catecholamines, and γ-aminobutyric acid seem to participate in this process. Finally, prenatal COC abuse has been also associated with functional changes in the hormones of the hypothalamic-pituitary-adrenal axis that mediate neuroendocrine responses. The purpose of this review is to summarize the neurodevelopmental consequences of prenatal COC abuse, to describe the pathophysiological pathways that underlie these consequences, and to provide implications for future research in the field.
Room temperature synthesis, crystal structure and selected properties of the new compound [Mn2(bipy)4SbS4](ClO4)
Authors: Anderer Carolin , Näther Christian , Bensch Wolfgang
Published: March 2016

The new compound [Mn2(bipy)4SbS4](ClO4) was prepared by a new synthetic route for the preparation of thioantimonates(V) that can be used even at room temperature. Mixing aqueous solutions of [Mn(bipy)3](ClO4)2 and Na3SbS4 · 9H2O leads to immediate crystallization of the pure compound. In the structure an SbS4
3– anion acts as a tetradentate bridge connecting two Mn2+ cations of [Mn(bipy)3]2+ complexes (bipy = 2,2′-bipyridine). The compound features a hitherto unknown [Mn2(bipy)4SbS4]+ cation. Bipy ligands of adjacent cations are arranged parallel to each other leading to weak off-center parallel π-π interactions stabilizing the crystals. Magnetic measurements indicate weak antiferromagnetic exchange interactions between the Mn2+ centers.
Acute Effects of Drop-Jump Protocols on Explosive Performances of Elite Handball Players
Authors: Dello Iacono Antonio , Martone Domenico , Padulo Johnny
Published: March 2016

Dello Iacono, A, Martone, D, and Padulo, J. Acute effects of drop-jump protocols on explosive performances of elite handball players. J Strength Cond Res 30(11): 3122–3133, 2016—This study aimed to assess the acute effects of vertical and horizontal drop jump–based postactivation potentiation (PAP) protocols on neuromuscular abilities in tasks such as jumping, sprinting, and change of direction (COD). Eighteen handball players were assessed before and after PAP regimens, consisting of either vertical single-leg drop-jumps (VDJ) or horizontal single-leg drop-jumps (HDJ) single-leg drop-jumps, on countermovement jump (CMJ), linear sprint, shuttle sprint, and agility performance. The HDJ led to greater improvement of the COD performance in comparison with the VDJ (−6.8 vs. −1.3%; p ≤ 0.05), whereas the VDJ caused greater improvement in the CMJ task compared with the HDJs (+6.5 vs. +1%; p ≤ 0.05). Moreover, the VDJ regimens compared with HDJ induced greater changes in most of the kinetic variables associated with vertical jumping performance, such as peak ground reaction forces (+9.6 vs. +1.3%), vertical displacement (−13.4 vs. −5.3%), leg-spring stiffness (+18.6 vs. +3.6%), contact time (−9.2 vs. −1.3%), and reactive strength index (+7.3 vs. +2.4%) (all comparisons with p ≤ 0.05). Conversely, the HDJ regimens were able to improve the COD performance only by reducing the contact time on COD more than the VDJ (−13.3 vs. −2.4% with p ≤ 0.05). The results showed that both PAPs were able to improve the performances that specifically featured similar force-orientation production. This investigation showed the crucial role that different and specific PAP regimens play in optimizing related functional performances. Specifically oriented vertical and horizontal single-leg drop-jump protocols represent viable means for achieving enhanced explosive-based tasks such as jumping and COD.
Imagens da Realeza, Heroísmo e Mulher em uma narrativa medieval ibérica – a Lenda de Gaia
Authors: Barros José D'Assunção
Published: March 2016

Este artigo objetiva examinar – através de uma narrativa medieval ibérica do século XIII chamada “Lenda de Gaia” – as relações de gênero e aspectos imaginários referentes às relações sociais e políticas do período. A narrativa examinada é apresentada em duas versões incluída em dois dos Livros de Linhagens portugueses, sendo analisadas comparativamente neste artigo.
Does 3D Phenotyping Yield Substantial Insights in the Genetics of the Mouse Mandible Shape?
Authors: Navarro Nicolas , Maga A Murat
Published: March 2016

We describe the application of high-resolution 3D microcomputed tomography, together with 3D landmarks and geometric morphometrics, to validate and further improve previous quantitative genetic studies that reported QTL responsible for variation in the mandible shape of laboratory mice using a new backcross between C57BL/6J and A/J inbred strains. Despite the increasing availability of 3D imaging techniques, artificial flattening of the mandible by 2D imaging techniques seems at first an acceptable compromise for large-scale phenotyping protocols, thanks to an abundance of low-cost digital imaging systems such as microscopes or digital cameras. We evaluated the gain of information from considering explicitly this additional third dimension, and also from capturing variation on the bone surface where no precise anatomical landmark can be marked. Multivariate QTL mapping conducted with different landmark configurations (2D vs. 3D; manual vs. semilandmarks) broadly agreed with the findings of previous studies. Significantly more QTL (23) were identified and more precisely mapped when the mandible shape was captured with a large set of semilandmarks coupled with manual landmarks. It appears that finer phenotypic characterization of the mandibular shape with 3D landmarks, along with higher density genotyping, yields better insights into the genetic architecture of mandibular development. Most of the main variation is, nonetheless, preferentially embedded in the natural 2D plane of the hemi-mandible, reinforcing the results of earlier influential investigations.
FluorescenceIn SituHybridization (FISH)-Based Karyotyping Reveals Rapid Evolution of Centromeric and Subtelomeric Repeats in Common Bean (Phaseolus vulgaris) and Relatives
Authors: Iwata-Otsubo Aiko , Radke Brittany , Findley Seth , Abernathy Brian , Vallejos C Eduardo , Jackson Scott A
Published: March 2016

Fluorescence in situ hybridization (FISH)-based karyotyping is a powerful cytogenetics tool to study chromosome organization, behavior, and chromosome evolution. Here, we developed a FISH-based karyotyping system using a probe mixture comprised of centromeric and subtelomeric satellite repeats, 5S rDNA, and chromosome-specific BAC clones in common bean, which enables one to unambiguously distinguish all 11 chromosome pairs. Furthermore, we applied the karyotyping system to several wild relatives and landraces of common bean from two distinct gene pools, as well as other related Phaseolus species, to investigate repeat evolution in the genus Phaseolus. Comparison of karyotype maps within common bean indicates that chromosomal distribution of the centromeric and subtelomeric satellite repeats is stable, whereas the copy number of the repeats was variable, indicating rapid amplification/reduction of the repeats in specific genomic regions. In Phaseolus species that diverged approximately 2–4 million yr ago, copy numbers of centromeric repeats were largely reduced or diverged, and chromosomal distributions have changed, suggesting rapid evolution of centromeric repeats. We also detected variation in the distribution pattern of subtelomeric repeats in Phaseolus species. The FISH-based karyotyping system revealed that satellite repeats are actively and rapidly evolving, forming genomic features unique to individual common bean accessions and Phaseolus species.
Suppression of F1 Male-Specific Lethality inCaenorhabditisHybrids bycbr-him-8
Authors: Ragavapuram Vaishnavi , Hill Emily Elaine , Baird Scott Everet
Published: March 2016

Haldane’s Rule and Darwin’s Corollary to Haldane’s Rule are the observations that heterogametic F1 hybrids are frequently less fit than their homogametic siblings, and that asymmetric results are often obtained from reciprocal hybrid crosses. In Caenorhabditis, Haldane’s Rule and Darwin’s Corollary have been observed in several hybrid crosses, including crosses of Caenorhabditis briggsae and C. nigoni. Fertile F1 females are obtained from reciprocal crosses. However, F1 males obtained from C. nigoni mothers are sterile and F1 males obtained from C. briggsae die during embryogenesis. We have identified cbr-him-8 as a recessive maternal-effect suppressor of F1 hybrid male-specific lethality in this combination of species. This result implicates epigenetic meiotic silencing in the suppression of F1 male-specific lethality. It is also shown that F1 males bearing a C. briggsae X chromosome are fertile. When crossed to C. briggsae hermaphrodites or F1 females derived from C. briggsae hermaphrodites, viable F2 and backcross (B2) progeny were obtained. Sibling males that possessed a C. nigoni X chromosome were sterile. Therefore, the sterility of F1 males bearing a C. nigoni X chromosome must result from dysgenic interactions between the X chromosome of C. nigoni and the autosomes of C. briggsae. The fertility of F1 males bearing a C. briggsae X chromosome provides an opportunity to identify C. nigoni loci that prevent spermatogenesis, and hence hermaphroditic reproduction, in diplo-X hybrids.