bluuebunny/crossref_metadata_2025 huggingface dataset:
El abuelazgo: enlace intergeneracional en la crianza y cuidado de la primera infancia
Authors: Marín Rengifo Alba Lucia , Palacio Valencia María Cristina
Published: November 2023

Objetivo. Describir algunos procesos de cuidado y crianza en la primera infancia que presentan los abuelos y las abuelas. Metodología. Este artículo se construyó desde una trayectoria hermenéutica, en la cual se cruzaron saberes legos y expertos a través de grupos focales y entrevistas a profundidad que permitieron descifrar los entramados relacionales de la participación de los abuelos y las abuelas en la formación de niños y niñas. Resultados. Se marca una distinción entre la participación central relacionada directamente con la crianza y la participación periférica con el cuidado ocasional o puntual; ya sea la una o la otra, el abuelazgo ―entendido como la participación del abuelo y la abuela en la crianza y cuidado de los nietos y las nietas― se constituye en un umbral de enlaces intergeneracionales que hacen visible algunas pistas de los cambios y transformaciones que se producen a partir de la reconfiguración de la propia maternidad, paternidad y filiación; un proceso que expresa, además, dinámicas parentales y formas de organización familiar diferentes. Conclusión. Se evidencian dilemas emocionales y afectivos, conflictos entre la presión por la solidaridad familiar y el ejercicio de la maternidad y la paternidad, así como tensiones derivadas de las sensibilidades legales y culturales en torno a la crianza y el cuidado de niños y niñas.
cuidado en el marco de la migración infantil
Authors: Sandoval Forero Eduardo Andrés , Román Reyes Rosa Patricia , González Becerril Juan Gabino
Published: November 2023

Objetivo. Exponer algunos aspectos sociodemográficos y la política del cuidado y protección de la migración infantil de México a los Estado Unidos. El artículo hace parte de una investigación que incluye el retorno obligado o voluntario de este sector de la población. Metodología. El trabajo se fundamenta en la perspectiva crítica de los estudios de la población utilizando la metodología comparativa y deductiva a la luz de la información bibliográfica, hemerográfica y estadística disponible. Resultados. Se realiza un diagnóstico sociodemográfico de la migración de niños mexicanos a Estados Unidos; se aborda y discute la política del cuidado y la denominada crisis humanitaria de la movilidad infantil en el contexto internacional. Conclusiones. Esta complejidad de la migración infantil internacional, enmarcada en la globalización económica, además de las crecientes cifras, conduce a conclusiones que atañen a la dimensión social y demográfica y a la violación a los derechos humanos y los derechos de los niños en contradicción con los instrumentos del derecho internacional y con las políticas antimigratorias que violan las garantías de los menores migrantes.
Cuidado, trabajo emocional y mercado: los servicios estéticos y corporales
Authors: Arango Gaviria Luz Gabriela
Published: November 2023

Objetivo. Argumentar sobre un sector laboral del campo del cuidado, a saber: el cuidado de la apariencia, específicamente los servicios estéticos y corporales de peluquería y manicure. Metodología. Se examinaron, desde una perspectiva de género, algunas de las paradojas y tensiones presentes entre género, cuidado y mercado en los servicios de cuidado de la apariencia en las ciudades de Bogotá, Campinas y Belo Horizonte. Resultados y conclusiones. La reflexión se organiza en torno a tres ejes: los efectos de la profesionalización de los servicios de peluquería y manicure sobre el trabajo de las mujeres; la mercantilización de las emociones en el trabajo de las manicuristas y las dimensiones reparadoras del cuidado del cabello en salones ‘étnicos’ brasileños.
La comunicación familiar. Una lectura desde la terapia familiar sistémica
Authors: Rodríguez Bustamante Alexander
Published: November 2023

Objetivo. Analizar la noción de comunicación en terapia familiar a partir de la perspectiva de la Escuela de Palo Alto (MRI). Metodología. Para esta revisión teórica se utilizó el enfoque cualitativo desde la perspectiva hermenéutica. Resultados y conclusiones. El hallazgo más relevante es la validación de la comunicación en la triada elocutiva entre el sistema familiar, el consultante y el terapeuta dando un significado apreciativo en la relación interpersonal que se gesta entre la familia, o alguno de sus subsistemas, con el sistema terapéutico. Se concluye el artículo con una idea que permanece en cada uno de los autores y que, para efectos de la interpretación, es posible denominar como lugares comunes en la terapia familiar: la familia y el terapeuta, una conversación que se construye.
Sentidos de familia en niños y niñas en condiciones de desplazamiento en Medellín (Colombia)
Authors: Uribe Muentes Diana María , Viveros Chavarría Edison Francisco
Published: November 2023

Objetivo. Develar algunos sentidos sobre familia construidos por niños y niñas de familias en condiciones de riesgo y desplazamiento en Medellín. Metodología. El método es cualitativo y se usaron entrevistas, grupos focales y talleres. Resultados y conclusión. En el presente artículo se exponen algunos sentidos sobre familia a partir de las vivencias de los niños y las niñas; el desplazamiento es tomado solo como contexto y no como objeto de estudio. Se concluye que estas vivencias configuran los sentidos de niños y niñas con respecto a sus familias. Estas vivencias son referencia ontológica y existencial, y acceden a ellas a través del lenguaje simbólico, de su discurso, de las narraciones y las formas de relación con sus familias. En este proceso emergieron el juego como forma de relación, las trasformaciones en la identidad y la familia como espacio de inclusión; constituyéndose así el cuidado y la protección como los sentidos más significativos otorgados por los niños y las niñas a sus familias.
Familia y discapacidad: consideraciones apreciativas desde la inclusión
Authors: Abad Salgado Ana María
Published: November 2023

Objetivo. Describir y relacionar las características de la dinámica familiar en el marco de la discapacidad, desde los fundamentos de la inclusión, en el municipio de Manizales (Caldas). Metodología. Para alcanzar dicho objetivo se recurre a un estudio cuantitativo, partiendo del enfoque empírico-analítico. Como instrumento se utilizó un cuestionario tipo encuesta, con una muestra de 364 familias, adelantado desde la perspectiva de la inclusión. Resultados. Se encontró que la condición de discapacidad altera la dinámica familiar y que su reconfiguración, desde los principios de la funcionalidad, favorece acciones incluyentes lideradas por la cuidadora tales como la equidad y el reconocimiento de la diferencia. Conclusión. Se concluye que los procesos de atención e intervención dirigidos a este colectivo deben partir de un enfoque centrado en la familia; asumiendo el principio sistémico, el cual sustenta que todo lo que afecta a la familia también afecta directamente a la persona con discapacidades y todo lo que afecte a esta persona incide directamente en su familia.
Seguridad alimentaria nutricional familiar en sectores populares: ¿responsabilidad de varones o mujeres?
Authors: Elisabet Cristaldo Patricia
Published: November 2023

Objetivo. Mostrar la dinámica relacional intergénerica en familias de sectores populares de un barrio de Córdoba, Argentina, para garantizar la seguridad alimentaria nutricional. Metodología. Se recurre a un estudio de casos integrado, realizando entrevistas en profundidad y observación participante; se aplicó para su análisis muestreo teórico y método comparativo constante con triangulación de datos y metodológica. Resultados. Varones y mujeres generan relaciones de poder jerárquicas y de autoridad complementarias para acceder a los alimentos y sus cuidados; ellos priman obtener el ingreso monetario y ellas adquirir alimentos mediante la compra, programas sociales y relaciones de parentesco para dispensar los cuidados alimentario-nutricionales adecuados a las preferencias, etapa evolutiva y condiciones laborales de cada miembro de la familia. Conclusión. Se concluye que los cambios a suscitar en las relaciones de género, para que sean más equitativas y democráticas, deberán abordar acciones positivas con los géneros que deconstruyan los sentidos de desigualdad e inequidad en las familias.
Hacia los enfoques generacionales e intergeneracionales: tensiones y perspectivas en las políticas públicas de juventud en América Latina
Authors: Vommaro Pablo Ariel
Published: November 2023

Objetivo. Analizar el estado de las políticas públicas de juventud en América Latina y el Caribe en los últimos años, en relación con dos elementos fundamentales: las diversidades y las desigualdades sociales. Metodología. El trabajo está basado en los resultados de una investigación colectiva acerca de las políticas públicas de inclusión social dirigidas a los jóvenes que se realizó en 10 países de la región (Argentina, Bolivia, Brasil, Colombia, Costa Rica, Cuba, Ecuador, El Salvador, Honduras y Uruguay). Este estudio estuvo a cargo de un equipo interdisciplinario e internacional, en el marco de un proyecto compartido entre UNESCO y CLACSO. Resultados y conclusiones. Las diversidades y las desigualdades sociales son elementos particularmente importantes entre las juventudes. El artículo enfatiza en las miradas generacional e intergeneracional, como componentes de las políticas públicas de juventud, mostrando las experiencias que se produjeron al respecto en la región.
Estructuras familiares incompletas y el desarrollo humano en las localidades de Bogotá
Authors: Niño Muñoz Diana , Solano Zea Nany , Almanza Rodríguez Martha
Published: November 2023

Objetivo. Analizar si en el corto plazo existe una relación bidireccional entre las estructuras monoparentales y la calidad de vida de los residentes de las localidades de Bogotá. Para ello se identificaron indicadores para diversas libertades instrumentales y para la pobreza multidimensional. Metodología. Se pone a discusión académica, la metodología propuesta por Ragin para evidenciar relaciones como un método para solventar las restricciones de información a largo plazo presentes en la ciudad. Asimismo, se presentan mapas georreferenciados que facilitan identificar patrones en el territorio. Resultados y conclusiones. Dadas las condiciones metodológicas se puede concluir que a corto plazo las familias monoparentales no tienen el protagonismo necesario para influir sobre el desarrollo de la ciudad. Y aunque no hay evidencia suficiente para detectar una relación bidireccional en el corto plazo entre las familias incompletas y la calidad de vida en las localidades, sí se puede encontrar una correspondencia unidireccional.
Efecto programa de cuidado cultural en la funcionalidad familiar: desde personas mayores con discapacidad, Facatativá, Cundinamarca
Authors: Casallas Hernández Nathalya , Velásquez Gutiérrez Florisa
Published: November 2023

Objetivo. Determinar el efecto en la funcionalidad familiar de un programa de cuidado cultural en personas mayores con discapacidad en Facatativá, Cundinamarca. Metodología. Estudio cuasiexperimental, sin grupo control, participaron 31 familias con personas mayores con discapacidad física. El programa fue aplicado por la enfermera investigadora con competencia cultural. La información fue recolectada con la escala de efectividad del funcionamiento familiar (ASF-E 20), procesada y analizada con métodos descriptivos y prueba de rango signado de Wilcoxon. Se consideraron aspectos éticos. Resultados y conclusiones. El programa de cuidado cultural de la salud obtuvo un efecto estadísticamente significativo en la funcionalidad familiar global y por metas desde las personas mayores con discapacidad (valor p<0,001); el programa tuvo efectos significativos, influidos principalmente por la comunicación asertiva del adulto mayor con su familia
Descripción de métodos de investigación y referentes teóricos en estudios colombianos que articulan la investigación e intervención con familias
Authors: Charry Higueras Maritza , Uribe López Meggy Andrea
Published: November 2023

Objetivo. Describir las temáticas, población, métodos, tipos de estudio, técnicas de investigación y referentes teóricos encontrados en estudios colombianos a partir de la realización de un estado del arte entre 2000 y 2011. Metodología. La metodología definida para el estado del arte fue cualitativa desde la perspectiva teórica hermenéutica a partir de investigaciones aplicadas sobre familia que expresaran responsabilidad social frente a la comprensión de los fenómenos sociales. Resultados y conclusiones. Se observa que los investigadores tienen la tendencia a usar combinaciones teóricas y no una única teoría para comprender la familia, lo que da cuenta de la renuncia a explicaciones monocausales; además empiezan a dar cuenta del uso de perspectivas epistemológicas liminales en investigación en las que se busca no solo producir conocimiento, sino también intervenir con familias.
Estudios de familia en clave de masculinidades. Estado de la discusión en Colombia
Authors: Gallego Montes Gabriel
Published: November 2023

Objetivo. Presentar la discusión de dos campos de conocimiento en Colombia: los estudios de familia y las masculinidades. Metodología. Se adelantó una revisión de la producción académica en ambas áreas del conocimiento. Resultados y discusión. Se presentan las tendencias de la investigación sobre familia y masculinidades, infiriéndose tres ejes sobre los que hay convergencia: representaciones de los hombres en la vida familiar y conyugal, relaciones de trabajo y familia y los estudios sobre paternidad. Se reconoce la trampa hermenéutica que tienen los estudios de familia en clave de masculinidades, en tanto son pocas las investigaciones donde se capta la voz y subjetividad de los varones al interpretar la vida familiar; se identifican tres áreas donde se requiere mayor investigación: varones y violencia intrafamiliar, trabajo remunerado y cuidado en clave de género y la comprensión de la fecundidad de los varones y su reproducción.
Tejidos para una ética de género desde el reconocimiento de la diferencia en perspectiva narrativa y arquetípica
Authors: Ruiz Gómez Norma Liliana
Published: November 2023

Objetivo. Argumentar los principales fundamentos para configurar una ética de género del reconocimiento de la diferencia narrativa y arquetípica. Metodología. La metodología es la hermenéutica fenomenológica de Paul Ricoeur desde su interpretación, articulada con la interpretación de Carl Gustav Jung. Resultados y conclusión. Este tipo de ética se construye desde la imbricación, con la teoría de la identidad narrativa propuesta por Ricoeur, con la articulación de las identidades de hombres y de mujeres desde la perspectiva de la psicología profunda de Jung, con la ética de la psicología profunda de Erich Neumann y la moral arquetípica de Jean Shinoda Bolen y, por último, las éticas del reconocimiento de Axel Honneth y el propio Ricoeur.
Commentary on Lee and Zaryab: Does groove really influence sexual selection?
Authors: Marin Manuela M.
Published: November 2023

Music is a stimulus that is known to have manipulative potential in different societal contexts. Misattributed arousal is one mechanism through which music may affect perception and behavior. Lee and Zaryab (this volume) present a study that examined the influence of groove on sexual selection in a simulated speed-dating paradigm, building upon research by Marin et al. (2017) and Chang et al. (2021). Their results indicate that groove ratings predicted sexual attraction among males, but not among females. This commentary discusses several methodological issues and suggests possible refinements for future studies on music-induced arousal transfer, which may ultimately enhance our understanding of how music can affect mate choice. Finally, I discuss the topic in the context of the origins of music and musicality.
Editors' Note
Authors: Müllensiefen Daniel , Hansen Niels Chr.
Published: November 2023

No abstract available
Breastfeeding in children with cleft lip and palate and its effect on surgical outcomes
Authors: Jar Alabbas Abdulghani , Alotaibi Adel Shabib , Alqahtani Hussain Ali , Alshaqaqeq Ghaida Ali , Alandanoosi Hosam Ibraheem , Alsulami Sultan Rubayan , Alosaimi Latifa Abdulrahman , Alyahya Awatef Sliman , Alsulami Musab Abdullah , Almohammadi Abdulrhman Awad , Aljaghthami Saud Obaid
Published: November 2023

Breastfeeding is a fundamental aspect of infant nutrition and development. However, children born with cleft lip and palate face unique challenges in breastfeeding due to structural anomalies in their facial and oral regions. This study explores the intricate landscape of CLP, covering its epidemiology, complex etiology involving genetic and environmental factors, and the specific challenges breastfeeding children with CLP and their mothers encounter. This review emphasizes the critical role of surgical interventions in CLP management, discussing the timing, techniques, and outcomes of these procedures. While surgical repair of CLP can enhance breastfeeding outcomes, it may also introduce temporary complications, including feeding difficulties, pain, and discomfort. Addressing these challenges requires a multidisciplinary approach involving healthcare professionals, specialized feeding equipment, emotional support, and targeted interventions. Moreover, the emotional well-being of mothers of infants with CLP is highlighted as an essential component of breastfeeding success. Maternal stress and emotional distress can hinder breastfeeding, emphasizing the importance of emotional support and counseling services. Successful breastfeeding in children with CLP is achievable with the right strategies and support systems, like comprehensive care, which acknowledges the complexity of CLP and emphasizes the need for a collaborative healthcare approach to ensure that children with CLP receive optimal nutrition and care during their critical early developmental stages.
Study prognostic significance of low platelet count in newborn admitted in neonatal intensive care unit (NICU) at tertiary care center
Authors: Chawda Vidit , Khasavat Shailendra , Patel Vishal , Chaudhari Khushbu , Patadia Jigisha
Published: November 2023

One of the most frequent haematological abnormalities found in new-borns is Thrombocytopenia. In neonates admitted to ICUs, thrombocytopenia develops in 18–35 % of all patients. With decreasing gestational age and birth weight, the incidence are increasing. Platelets are formed by megakaryocytes and are present in the bloodstream for 5–7 days. Platelets are known as regulators of haemostasis and thrombosis. Platelets become active in the blood resulting vascular injury. Thrombopoiesis is the formation of platelets in the Bone marrow. Thrombopoietin is the main regulator of thrombopoiesis. Thrombopoietin affects most aspects of the production of platelets. The process of Thrombopoiesis is caused by the breakdown of proplatelets (mature megakaryocyte membrane pseudopodia projections).

Aim is to assess the prevalence, causes, treatment modalities, and prognostic outcomes of thrombocytopenia in neonates.

Research design was carried out in the Department of paediatrics and neonatology, Government Medical College, Surat from October 2020 to April 2022. Data were collected from MRD section. Platelet numbers were estimated from whole blood EDTA sample taken from neonates for routine medical management. Data were analysed for Age, Sex, Intraventricular haemorrhage, other bleeding manifestation, Necrotising enterocolitis, Sepsis, Fungal infection & final outcome.

Out of 1265 neonates admitted to the NICU at Department of paediatrics and neonatology, GMC, Surat 450 neonates were found to have thrombocytopenia. Male neonates are more significantly affected than female neonates.

The early platelets drop even without the later development of thrombocytopenia is an early indicator of poor outcome and major morbidities, mainly infection.
«Неполезное чтение» печорских крестьян
Authors: Волкова Татьяна
Published: November 2023

В статье анализируются особенности сюжета и композиции рифмованной Повести о купце и жене его лукавой по списку, найденному на Нижней Печоре и хранящемуся в Усть-Цилемском собрании Пушкинского Дома, показывается оригинальность печорского варианта Повести по сравнению со стихотворной фацецией на сходную тему, изданной А.В. Кокоревым в 1941 г.
Петербургская лирика Александра Кушнера в системе сверхтекста русской литературы
Authors: Sadzińska Ewa
Published: November 2023

Статья посвящена феномену сверхтекста, его характеристике и классификациям. Особое внимание уделяется Петербургскому тексту Александра Кушнера. Рассматриваются ключевые для данного сверхтекста образы и их репрезентации в лирике Кушнера, а также делается попытка определить характер диалога со сложившейся литературной традицией.
The hegemony of values: Revisiting Stanisław Pietraszko’s concept of culture with Antonio Gramsci’s theory of hegemony
Authors: Fereński Piotr Jakub
Published: November 2023

In my reinterpretation of Stanisław Pietraszko’s writings, I seek to identify their elements that exhibit some affinity with the concept of cultural hegemony, which germinated from entirely different ideological soil and has been developed under different historical circumstances. The idea of hegemony is usually traced back to Antonio Gramsci’s texts, though also to the work of other scholars inspired by Karl Marx’s thought, including the British philosophers who founded cultural studies. I argue that in distancing himself from all Marxism-underpinned theories, therein those that evolved toward semiology, Pietraszko was prompted not only by his philosophical views on the ontology of culture and possibilities of studying it but also by the social and political conjuncture in which hedeveloped his conception of culture (specifically, the socialist or communist regimes in Eastern Europe). I ponder how the two divergent models of understanding culture (i.e. culture defined in terms of ways of life and the idea of cultural hegemony) can be brought together. In my argument, I consider various media and communication forms in public space, such as murals, graffiti, posters, billboards, monuments and the like. It is in them that I see manifestations of values.
O Programa Patronos da Arte Contemporânea e a coleção da Pinacoteca do Estado de São Paulo
Authors: Tinoco Bianca Andrade
Published: November 2023

Mantido pela Pinacoteca do Estado de São Paulo desde 2012, o programa Patronos da Arte Contemporânea permitiu a aquisição de mais de 130 obras em 11 anos. O quantitativo altera o percentual de mulheres artistas representadas no museu, inclui os primeiros trabalhos de artistas indígenas contemporâneos, amplia o conjunto de artistas afro-brasileiros e insere no acervo categorias de linguagem até então ausentes ou pouco exploradas, como o vídeo e a performance. Favorável para a instituição, a parceria também traz benefícios para os patronos, porém enseja a discussão de questões éticas. A análise do programa inspira a consideração de medidas que permitam um equilíbrio entre interesses relacionados ao patrimônio artístico e aqueles relativos ao mercado de arte.
The Collatz Conjecture: A New Perspective from Algebraic Inverse Trees
Authors: Diedrich Eduardo
Published: November 2023

This paper addresses the Collatz Conjecture, an open question in mathematics that postulates all positive integers will eventually reach one when a pair of specific operations are repeatedly applied. Despite its apparent simplicity, the conjecture lacks a formal proof. To tackle this enigma, we introduce Algebraic Inverse Trees (AITs), data structures that trace inverse operations of the Collatz sequence. This new approach not only elaborates our unique methodology but also sheds light on the underlying complexities of the Collatz Conjecture.
Inula helenium subsp. Pseudohelenium: Phenolic Content, In Vitro Antimicrobial, Antioxidant, Antiproliferative, and DNA Protective Activities
Authors: Alan Yusuf , Yılmaz Nimet , Cabuk Mehmet
Published: November 2023

Plants have been used in alternative medicine for centuries in the treatment of many diseases with the metabolites they contain. The goal of this work was to investigate the phenolic profile, antioxidant capacity and biological activity of I. helenium subsp. pseudohelenium extracts. Phe-nolic (HPLC) substances in leaf ethanol (L-EtOH), leaf pure water (L-PW), root ethanol (R-EtOH), and root pure water (R-PW) extracts of Inula helenium subsp. pseudohelenium plant were investi-gated. Also, in vitro the antimicrobial (hollow agar), antioxidant (DPPH, ABTS.+, FRAP, CU-PRAC), antiproliferative (MTT assay against HT-29, MCF-7 and L-929), and DNA (Agarose gel electrophoresis) protective activities of the samples were examined. Although gallic acid was not detected in the extracts, the presence of curcumin was detected only in EtOH extracts. L-EtOH exhibited the best antimicrobial activity. According to the antioxidant results, it was found that the L-EtOH extract had an activity profile close to the standard antioxidants in general. It was also found that the L-EtOH extract stabilized the DNA by disrupting the scavenging effect of H2O2+DMSO. According to the antiproliferative activity results, EtOH extracts exhibited the strongest effect, especially against MCF7. When evaluated in general terms, it was found that L-EtOH extract showed better activity than other extracts. It is important to conduct more in vivo and in vitro studies after isolating the active components of extracts e.g. L-EtOH, which have good effects in terms of biological activity.
Modelling Method for Aeroelastic Low Engine Order Excitation Originating from Upstream Vanes’ Geometrical Variability
Authors: Gambitta Marco , Beirow Bernd , Schrape Sven
Published: November 2023

The manufacturing geometrical variability in axial compressors is a stochastic source of uncertainty, implying that the real geometry differs from the nominal design. This causes the real geometry to lose the ideal axial symmetry. Considering the aerofoils of a stator vane, the geometrical variability affects the flow traversing it. This impacts the downstream rotor, especially when considering the aeroelastic excitation forces. Optical surface scans coupled with a parametrization method allow for acquiring the information relative to the real aerofoils geometries. The measured data are included in a multi-passage and multi-stage CFD setup to represent the mistuned flow. In particular, low excitation harmonics on the rotor vane are introduced due to the geometrical deviations of the upstream stator. The introduced low engine orders as well as their amplitude depend on the stator geometries and their order. A method is proposed to represent the phenomena in a reduced CFD domain, limiting the size and number of solutions required to probabilistically describe the rotor excitation forces. The resulting rotor excitation forces are reconstructed as a superposition of disturbances due to individual stator aerofoils geometries. This indicates that the problem is linear in in the combination of disturbances from single passages.
Age-Related Decline in Brain Myelination: Quantitative Macromolecular Proton Fraction Mapping, T2-Flair Hyperintensity Volume, and Anti-myelin Antibodies 7 Years Apart
Authors: Khodanovich Marina , Svetlik Mikhail , Naumova Anna , Kamaeva Daria , Usova Anna , Kudabaeva Marina , Anan’ina Tatyana , Wasserlauf Irina , Pashkevich Valentina , Moshkina Marina , Obukhovskaya Victoria , Kataeva Nadezhda , Levina Anastasia , Tumentceva Yana , Yarnykh Vasily
Published: November 2023

Age-related myelination decrease is considered one of the likely mechanisms of cognitive decline. The present study is based on the longitudinal assessment of global and regional myelination of the normal adult human brain using the fast macromolecular fraction (MPF) mapping. Additional markers were age-related changes in white matter (WM) hyperintensities on FLAIR-MRI and the levels of anti-myelin autoantibodies in serum. Eleven healthy subjects (33–60 years in the first study) were scanned twice, 7 years apart. An age-related decrease in MPF was found in global WM, GM, and mixed WM-GM, as well as in 48 out of 82 examined WM and GM regions. The greatest decrease in MPF was observed for the frontal WM (2-5%), genu of the corpus callosum (CC) (4.0%) and caudate nucleus (5.9%). The age-related decrease in MPF significantly correlated with an increase in the level of antibodies against myelin basic protein (MBP) in serum (r = 0.69 and r = 0.63 for global WM and mixed WM-GM, correspondingly). The volume of FLAIR hyperintensities increased with age but did not correlate with MPF changes and the levels of anti-myelin antibodies. MPF mapping showed high sensitivity to age-related changes in brain myelination, providing the feasibility of this method in clinics.
Cx4Mab-1: a Novel Anti-mouse CXCR4 Monoclonal Antibody for Flow Cytometry
Authors: Ouchida Tsunenori , Suzuki Hiroyuki , Tanaka Tomohiro , Kaneko Mika K , Kato Yukinari
Published: November 2023

The CXC chemokine receptor 4 (CXCR4, CD184) is a member of the G protein-coupled receptor family that is expressed in most leukocytes. Overexpression of CXCR4 is associated with poor prognosis in not only hematopoietic malignancy but also solid tumors. Because CXCR4 is an attractive target for tumor therapy, reliable preclinical murine models using anti-CXCR4 monoclonal antibodies (mAbs) have been warranted. This study established a novel anti-mouse CXCR4 (mCXCR4) mAb using the Cell-Based Immunization and Screening (CBIS) method. Flow cytometric analysis showed that an anti-mCXCR4 mAb, Cx4Mab-1 (rat IgG2a, kappa), recognized mCXCR4-overexpressed Chinese hamster ovary-K1 (CHO/mCXCR4) cells and endogenously mCXCR4-expressing mouse myeloma P3X63Ag8U.1 (P3U1) cells. Furthermore, Cx4Mab-1 did not recognize mCXCR4-knockout P3U1 cells. The dissociation constants of Cx4Mab-1 for CHO/mCXCR4 and P3U1 were determined as 6.4 × 10−9 M and 2.3 × 10-9 M, respectively, indicating that Cx4Mab-1 possesses a high affinity to both endogenous and exogenous mCXCR4-expressing cells. These results indicate that Cx4Mab-1 could be a useful tool for preclinical mouse models.
Validation of the Comprehensive Feeding Practices Questionnaire (CFPQ) With Portuguese Caregivers of 2-to-8-Year-Olds
Authors: Santos Ana F. , Fernandes Marília , Fernandes Carla , Barros Luísa , Veríssimo Manuela
Published: November 2023

Recent findings have demonstrated an increase in the prevalence of childhood obesity and overweight in Portugal, urging the need to study modifiable risk factors such as parental feeding practices. The Comprehensive Feeding Practices Questionnaire (CFPQ) is an important self-report measure assessing a broad range of responsive and non-responsive feeding practices. However, the CFPQ has not yet been validated in Portugal. Therefore, the present study aimed to test the validity of this measure with Portuguese parents of 2- to 8-year-old children. A sample of 409 parents completed a Portuguese-adapted version of the CFPQ and the already validated Child Feeding Questionnaire (CFQ). Confirmatory Factor Analysis (CFA), Exploratory Factor Analysis (EFA), and psychometric analysis were conducted. CFA demonstrated the original 12-factor structure did not fit the sample. EFA identified an 8-factor structure, comprising 29 items: Monitoring, Modeling, Environment, Involvement, Emotion Regulation, Restriction for Weight Control, Restriction for Health, and Pressure. Findings suggest that parental feeding practices are sensitive to parents’ background culture and children’s developmental period.
Equity Price Dynamics Under Shocks: In Distress or Short Squeeze
Authors: Hui Cho-Hoi , Lo Chi-Fai , Liu Chi-Hei
Published: November 2023

A simple bounded stochastic motion is employed for modelling equity price dynamics under shocks, where the prices are constrained to lie between two positive bounds. While the stochastic process has an inaccessible boundary, the other boundary is quasi-bounded, implying that the boundary can be breached if the probability leakage condition is met. The quasi-boundedness of the process at the boundary can thus provide an indicator of possible risk of equities under price shocks. Empirical calibration of model parameters of the proposed process for equities can be performed easily due to the availability of an analytically tractable probability density function which generates fat-tailed distributions consistent with empirical observations. The volatility and mean-reversion of the S&P500 dynamics calibrated by the process is positively and negatively co-integrated respectively with the VIX index representing the level of market distress. The process captures the high likelihood of Hertz’s default about two months earlier, using only information until that point, and before the firm filed for Chapter 11 bankruptcy in May 2020 as a result of the Covid-19 pandemic. Empirical calibration of the process for GameStop’s stock price shows that the short squeeze of the stock occurred when the condition for breaching an upper boundary was met on 14 January 2021, i.e., about two weeks before major short sellers closed out their positions with significant losses. The trading volume of the stock was positively co-integrated with the probability leakage ratio.
Chromatic Effects of Supplemental Light on Fruit Quality of Strawberries
Authors: Tang Ni , Wang Jiyong , Zhang Baofeng , Chen Hao , Qiu Min
Published: November 2023

Supplemental light is widely applied in greenhouses for promotions of the product and flavors of strawberries in global markets. Present selections of colored lights are, however, quite empirical or qualitative, from the aspect of photometry or colorimetry. The accurate control of chromatic parameters of supplemental light and their chromatic influences on fruit quality has been under-studied. In this study, color parameters including correlated color temperatures (CCTs) and illuminance of supplement lights are precisely controlled using a digitally color-coding method. We systematically investigate the chromatic effect of supplemental light on five parameters of strawberries: plant height, single weight, fruit hardness, soluble solids, and titratable acids. Results show that the supplement light generally lowers down the single weight and the fruit hardness, increases the plant height, the contents of soluble solids and titratable acids. The chromatic dependences for the five parameters are different and might be strengthened, weakened, or shifted by light illuminance. We demonstrate the beneficial roles of supplemental light in accelerating the maturation and enhancing the flavor of strawberries in greenhouses cultivation. The results pro-vide valuable guidance for the effective cultivation of strawberries. Moreover, the controlling method for accurate colors is ready for the implementation of supplemental lights in other fruits or plants.
The Nexus between ESG Reporting and Individual Investment Decisions: Evidence from Vietnam
Authors: Dzung Nguyen Thi Phuong , Toan Phan Huy , Hieu Le Trung , Linh Nguyen Thi , Hang Hoang Thi
Published: November 2023

In recent years, the implementation and disclosure of ESG information has become indispensable for companies around the world. Companies need to publish ESG reports to meet the requirements of shareholders, investors, and society. Therefore, this article aims to study the impact of ESG report information on the investment decisions of individual investors at Vietnamese stock markets. We apply Theory of Planned Behavior (TPB) to examine the "attitude" of individual investors towards ESG reports and the "investment intentions” on ESG reported companies. We employ logistic regression to analyze a usable sample of 232 individual investors. It is found that ESG reports have a nexus with the decision- making of individual investors. The investors pay more attention to Governance (G) information than Social (S) information and Environmental (E) information in ESG reports when making investment decisions. These findings would promote the listed companies and regulatory agencies to disclosure more information and issue regulations on ESG reports to encourage individual investors at emerging stock markets.
Thermosensitive Chitosan Hydrogels as a Vehicle for Iron Dextran as a Potential Strategy for Parenteral Nutrient Supplementation
Authors: Durán Emerson , Neira-Carrillo Andrónico , Oyarzun-Ampuero Felipe , Valenzuela Carolina
Published: November 2023

Iron deficiency anemia (IDA) is a world health problem for humans and other mammals; affecting critical stages of development. Pigs have been used as an experimental model for the study and prevention of anemia because of physiological and metabolic similarities with humans. Iron dextran particles (IDP) are used for intramuscular (IM) IDA treatments in pigs, but are insufficient for prevention of anemia due to quick metabolization. Therefore, the objective of this study was to develop chitosan thermosensitive hydrogels (CTH) formulations and to study their potential as a mammalian parenteral iron dextran supplementation strategy. CTH were loaded with IDP at increasing iron concentrations (0.1, 0.2 and 0.4 g of theorical iron/g of chitosan) and characterized as an IM iron supplement. All the CTH-IDP formulations were thermosensitive and can be injected IM at ~4 °C, with a significant rise in viscosity between 25-37 °C. IDP content was physically trapped in the chitosan hydrophobic gel at 37 °C, without evidence of chemical bonding. We conclude that CTHs are a promising strategy for IM delivery strategy of IDP, and these results may be useful for future iron supplementation studies in pigs, humans and other mammals.
Fatal SARS-CoV-2 Infection in a Domestic Cat in Hungary
Authors: Szilasi Anna , Kertész Péter , Dénes Lilla , Déri Dániel , Henczkó Judit , Pályi Bernadett , Mándoki Míra , Balka Gyula
Published: November 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide since its emergence and is causing the disease COVID-19. According to WHO, this is a zoonotic disease. Several cases have already been discovered where companion animals were affected due to virus spillover from humans, however, the symptoms are mild in most cases. We report the first documented case of SARS-CoV-2 infection and death of a domestic cat (Felis silvestris catus) in Hungary, where no other disease could be detected.
Impact of [18F]PSMA-1007 PET/CT Comparative to [18F]FLUOROCHOLINE PET/CT on Treatment Decision for Prostate Cancer Patient on Biological Recurrence: A Multicentric Prospective Observational Study
Authors: FEVRIER Agathe , Bouron Clément , De Vries Manon , Medhioub Ouassim , Lacoeuille Franck , Mention Pierre-Jean
Published: November 2023

Purpose: Prostate cancer is the most common male prevalent malignancy in Europe. Biological recurrence occurs in 20-40% of patients within 10 years following treatment. [18F]F-Choline PET/CT is the most used technique for detecting recurrent disease but is rarely positive for low PSA levels. [18F]PSMA-1007 PET/CT allows early detection of recurrence sites.
Methods: We conducted a prospective multicenter study. Each patient had access to a [18F]F-Choline and [18F]PSMA PET/CT. The primary endpoint was to determine the therapeutic impact of the [18F]PSMA comparative to [18F]F-Choline PET/CT. Secondary endpoints were the diagnostic performance and the correlation between PET/CT parameters and prognostic factors of prostate disease.
Results: 47 patients were included. A therapeutic modification was observed in 36% of them between what the clinicians expected after the [18F]F-Choline PET/CT and what they finally decided after the [18F]PSMA PET/CT. Diagnostic performance of [18F]F-Choline was 28% versus 70% for [18F]PSMA with a significant difference. With [18F]PSMA PET/CT, there was a significative correlation between PSA level of biological recurrence and SUVmax but not between ISUP score and SUVmax of the selected lesion.
Conclusion: This study found a modification in therapeutic management following [18F]PSMA PET/CT in one third of patients. This change could result in earlier and better management with detection of lesions at a lower PSA level than is possible with [18F]F-Choline.
Prediction Approach of Crack Width for FRP Reinforced Concrete Flexure Members of Pavement and Girder in Highway Structures
Authors: Lu Tao , Dong Fenghui , Zhang Yongjie , Liu Min , She Mingxing , Ma Chaohui
Published: November 2023

As the general acceptance of fiber-reinforced polymer (FRP) in the concrete construction industry continues to rise, it is increasingly imperative that the crack width of FRP reinforced concrete members of pavement and girder be predicted with good accuracy due to strengthening of RC pavement, slabs or beams structures using FRP is known to control crack width. However, no specific provisions are provided by most international design codes for predicting crack width in FRP reinforced concrete flexure members. In this paper, five formulas for predicting the crack width for FRP reinforced structures are derived from three common computational theories which including statistical method, comprehensive theory, and bond-slip theory. The formula of statistical method is simplest, but the parameters depend on much sample data. The comprehensive and slippage theory based on semi-empirical statistical crack spacing are obtained through the calculation of non-uniformity coefficient of strain. The comprehensive and slippage theory based on semi-empirical axial force balance are obtained through the calculation of tensile reinforcement factor. The comparative analysis of performance of five formulas is carried out. The results indicate that the formula from comprehensive theory based on semi-empirical statistical crack spacing is recommended for predicting the crack width of FRP reinforced concrete flexural structure.
Lateral Control Calibration and Testing in a Co-simulation Framework for Automated Vehicles
Authors: Bui Duc-Tien , Li Hexuan , De Cristofaro Francesco , Eichberger Arno
Published: November 2023

Lateral vehicle control is a high importance in automated vehicles as it directly influences the vehicle’s performance and safety during operation. The Linear Quadratic Regulator (LQR) controller stands out due to its high-performance characteristics and is used in the open source for self driving functions. However, a notable limitation of the current approach is the manual calibration of LQR controllers based on the experience and intuition of the designers, leading to empirical uncertainties. To address this issue and enhance the lateral control performance, this paper concentrates on refining the LQR by employing three optimization algorithms: Artificial Bee Colony Optimization (ABC), Genetic Algorithm (GA), and Particle Swarm Optimization (PSO). These algorithms aim to overcome the reliance on empirical methods and enable a data-driven approach to LQR calibration. By comparing the outcomes of these optimization algorithms to the manual LQR controller within an offline multibody simulation as testing platform, the study highlights the superiority of the best-performing optimization approach. Following this, the optimal algorithm is implemented on a real-time system for the full vehicle level, revealing the Model-in-the-Loop and the Hardware-in-the-Loop gap up to 78,89% with lateral velocity when we use Relative Error Criterion (REC) method to validate and 2.35m with lateral displacement when considering by maximum absolute value method.
Non-Fusion Versus Fusion Surgery in Pediatric Idiopathic Scoliosis
Authors: Larson A. Noelle , Marks Michelle Claire , Gonzalez Sepulveda Juan Marcos , Newton Peter O. , Devlin Vincent J. , Peat Raquel , Tarver Michelle E. , Babalola Olufemi , Chen Allen L. , Gebben David , Cahill Patrick , Shah Suken , Samdani Amer , Bachmann Keith , Lonner Baron ,   the Harms Study Group
Published: November 2023

Background:

Vertebral body tethering and other non-fusion techniques for the treatment of pediatric idiopathic scoliosis are increasing in popularity. There is limited physician consensus on this topic as the result of a paucity of published data regarding which patients most benefit from non-fusion strategies. Thus, much of the decision-making is left to patients and parents, who must select a treatment based on their goals and values and the information available from health-care providers, the internet, and social media. We sought to understand patient and family preferences regarding the attributes of fusion versus non-fusion surgery that drive these choices.

Methods:

Patients and families were recruited from 7 pediatric spine centers and were asked to complete a survey-based choice experiment that had been jointly developed with the U.S. Food and Drug Administration (FDA) to evaluate patient preferences. Choices between experimentally designed alternatives were analyzed to estimate the relative importance of outcomes and requirements associated with the choice options (attributes). The attributes included appearance, confidence in the planned correction, spinal motion, device failure, reoperation, and recovery period. The inclusion criteria were (1) an age of 10 to 21 years and (2) a diagnosis of adolescent idiopathic scoliosis in patients who were considering, or who had already undergone, treatment with fusion or non-fusion surgery. Preference weights were estimated from the expected changes in choice given changes in the attributes.

Results:

A total of 344 respondents (124 patients, 92 parents, and 128 parent/patient dyads) completed the survey. One hundred and seventy-three patients were enrolled prior to surgery, and 171 were enrolled after surgery. Appearance and motion were found to be the most important drivers of choice. For the entire cohort, fusion was preferred over non-fusion. For patients who were considering surgery, the most important attributes were preservation of spinal motion and appearance.

Conclusions:

Patients and families seeking treatment for idiopathic scoliosis value appearance and preservation of spinal motion and, to a lesser extent, reoperation rates when considering fusion versus non-fusion surgery.
Integration of Customer Needs in Sativa Mouthwash Design With Quality Function Development (QFD) Approach
Authors: Zafriana Lusi , Setiawatie Ernie Maduratna
Published: November 2023

Public awareness of oral-hygiene and health has influenced the increase demand for mouthwash products. To support the green innovation program, a mouthwash made from herbs and halal is needed. Sativa mouthwash is an innovative product using 3% Nigella Sativa extract. The QFD method is used as an evaluation of the productivity of Sativa mouthwash through the preparation of the HoQ matrix. It shows the level of connectedness between Customer and Technical Importance to get priority on the main technical interests that must be carried out immediately by the production company. The results of HoQ matrix calculation shows the highest-ranking attributes of the product is Nigella Sativa content, Raw Material Management, and Halal Label Design. The technical priority to achieve the customer interest attributes is packaging type. This means that the attributes of adding and processing Nigella Sativa ingredients that are right and labelled as halal have unique characteristics that greatly affect the sales productivity of Sativa Mouth Wash products. However, on the attribute of the type of packaging, Sativa Mouth Wash has not yet produced in sachets or small bottles which provide convenience and practicality that is needed by the customers