bluuebunny/crossref_metadata_2025 huggingface dataset:
O Valor do Capital Intelectual da Apple Inc., segundo o Método de Andriessen (2004) em 31 de Dezembro de 2020
Authors: Ramada Óscar
Published: September 2023

Este trabalho tem como objetivo conhecer quanto vale o capital intelectual da APPLE INC, no dia 31 de dezembro de 2020, de acordo com o método de ANDRIESSEN (2004). Trata-se de um método integrado que de uma forma projetiva, permite conhecer neste caso em USD o referido valor. O valor encontrado foi de 785396 milhões de USD. Associado a este valor encontram-se definidas 3 competências nucleares: Desenho e Desenvolvimento de Hardware e Software (Competência Nuclear 1, com o valor de 409058 milhões de USD), Acessórios Diversos (Competência Nuclear 2, com o valor de 175575 milhões de USD) e Serviços Tecnológicos (Competência Nuclear 3, com o valor de 200763 milhões de USD). Trata-se de um método que é, sobretudo, mais indicado para implementar no caso de empresas pertencentes ao setor tecnológico onde a alta tecnologia tem um maior relevo oriundo da existência e utilização do capital intelectual altamente qualificado. No caso da APPLE INC, constata-se que ele surge fortemente associado à existência da inovação particularmente visível no caso de meios de (tele)comunicação (computadores, tablets, telemóveis) bem como acessórios e serviços conexos. A maçã, conclui-se, está longe de aparecer trincada. Pelo contrário, deve aparecer inteira.
Pre-Exposure Prophylaxis and HIV Incidence
Authors: Mann Samuel
Published: September 2023

Pre-Exposure Prophylaxis (PrEP) is a drug that, as demonstrated in clinical trials, when taken makes the user virtually immune to HIV. This has led to numerous countries making the drug available, but little is known about the population level effects of PrEP. Using panel data from 40 European countries I study the effect of countries adopting WHO recommendations to make PrEP available to citizens. I demonstrate that PrEP availability leads to around 15–20 % fewer new HIV infections. My results indicate that PrEP can be an effective tool in reducing HIV incidence.
Genetic markers associated with adverse reactions of radioiodine therapy in thyroid cancer patients
Authors: Denisenko Natalia P. , Kachanova Anastasia A. , Sychev Ivan V. , Shuev Gregory N. , Perfilieva Oksana M. , Mukhamadiev Reis H. , Kazakov Ruslan E. , Milyutina Olga I. , Konenkova Olga V. , Ryzhkin Sergey A. , Zhmaeva Elena M. , Kirienko Sergey L. , Ivashchenko Dmitriy V. , Bure Irina V. , Ametov Alexander S. , Poddubnaya Irina V. , Mirzaev Karin B. , Sychev Dmitry A.
Published: September 2023

Objectives

Radioactive iodine therapy is considered for patients with certain clinicopathological factors that predict a significant risk of recurrence, distant metastases of thyroid cancer or disease-specific mortality. The aim of the study was to investigate the association between polymorphisms of genes, products of which are involved in the processes of DNA damage response and autophagy, and the adverse reactions of radioiodine therapy in thyroid cancer patients.

Methods

The study included 181 patients (37 men, 144 women; median age 56 [41; 66.3] years) with histologically confirmed thyroid cancer and a history of thyroidectomy who received radioiodine therapy. NFKB1, ATM, ATG16L2, ATG10, TGFB1, and TNF polymorphisms were determined by allele-specific realtime-PCR.

Results

The frequency of adverse reactions was the following: gastrointestinal symptoms – 57.9 %, local symptoms – 65.8 %, cerebral symptoms – 46.8 %, fatigue – 54.4 %; signs of sialoadenitis six months after radioiodine therapy – 25.2 %. TT genotype carriers of ATG10 rs1864183 had higher frequency of gastrointestinal symptoms (vs. CC+CT), the CC genotype carriers of ATG10 rs10514231 had significantly more frequent cerebral symptoms (vs. CT+TT), as well as AA genotype carriers of TGFB1 rs1800469 (vs. AG+GG). CC genotype of ATG10 rs10514231 increased the incidence of radioiodine-induced fatigue, whereas GA genotype of the ATM rs11212570 had a protective role against fatigue. TGFB1 rs1800469 was associated with signs of sialoadenitis six months after radioiodine therapy.

Conclusions

Genetic factors may contribute to the occurrence of adverse reactions of radioiodine therapy in thyroid cancer patients.
The archaeal Lsm protein from Pyrococcus furiosus binds co-transcriptionally to poly(U)-rich target RNAs
Authors: Reichelt Robert , Rothmeier Tamara , Grünberger Felix , Willkomm Sarah , Bruckmann Astrid , Hausner Winfried , Grohmann Dina
Published: September 2023

Posttranscriptional processes in Bacteria include the association of small regulatory RNAs (sRNA) with a target mRNA. The sRNA/mRNA annealing process is often mediated by an RNA chaperone called Hfq. The functional role of bacterial and eukaryotic Lsm proteins is partially understood, whereas knowledge about archaeal Lsm proteins is scarce. Here, we used the genetically tractable archaeal hyperthermophile Pyrococcus furiosus to identify the protein interaction partners of the archaeal Sm-like proteins (PfuSmAP1) using mass spectrometry and performed a transcriptome-wide binding site analysis of PfuSmAP1. Most of the protein interaction partners we found are part of the RNA homoeostasis network in Archaea including ribosomal proteins, the exosome, RNA-modifying enzymes, but also RNA polymerase subunits, and transcription factors. We show that PfuSmAP1 preferentially binds messenger RNAs and antisense RNAs recognizing a gapped poly(U) sequence with high affinity. Furthermore, we found that SmAP1 co-transcriptionally associates with target RNAs. Our study reveals that in contrast to bacterial Hfq, PfuSmAP1 does not affect the transcriptional activity or the pausing behaviour of archaeal RNA polymerases. We propose that PfuSmAP1 recruits antisense RNAs to target mRNAs and thereby executes its putative regulatory function on the posttranscriptional level.
A proposed neural network model for obtaining precipitable water vapor
Authors: Al-Eshmawy Hadeer , Abdelfatah Mohamed A. , El-Fiky Gamal S.
Published: September 2023

The atmospheric Precipitable water vapor (PWV) is a variable key for weather forecasting and climate change. It is a considerable component of the atmosphere, influencing numerous atmospheric processes, and having physical characteristics. It can be measured directly using radiosonde stations (RS), which are not always accessible and difficult to measure with acceptable spatial and time precision. This study uses the artificial neural network (ANN) application to propose a simple model based on RS data to estimate PWV from surface metrological data. Ten RS stations were used to develop the new model for eight and a half years. In addition, two and a half years of data were used to validate the developed model. The study period is based on the data accessible between 2010 and 2020. The new model needs to collect (vapor pressure, temperature, latitude, longitude, height, day of year, and relative humidity) as input parameters in ANN to predict the PWV. The ANN model validations were based on the root mean square (RMS), correlation coefficient (CC), and T-test. According to the results, the proposed ANN can accurately predict the PWV over Egypt. The results of the new ANN model and eight other empirical models (Saastamoinen, Askne and Nordius, Okulov et al., Maghrabi et al., Phokate., Falaiye et al. (A&B), Qian et al. and ERA 5) are compared in addition, the new PWV model can achieve the best performance with RMS of 0.21 mm. The new model can serve as a will be of practical utility with a high degree of precision in PWV estimation.
Crystal structure of 2-(5-phenyl-1-(quinolin-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenol, C24H19N3O
Authors: Zeng Dai , Tan Kai , Fang Ziyan , Xing Aiping
Published: September 2023

C24H19N3O, monoclinic, P21/c (no. 14), a = 10.4783(5) Å, b = 11.7171(5) Å, c = 14.9194(6) Å, β = 93.991(2)°, Z = 4, V = 1827.29(14) Å3, R
gt(F) = 0.0521, wR

ref
(F
2) = 0.1508, T = 150(2) K.
Energieeffizienz als Geschäftschance für den Maschinen- und Anlagenbau?
Authors: Rösler Jonathan , Lorenz Selina , Friedli Thomas , Palmié Maximilian
Published: September 2023

Angesichts steigender Energiekosten ist das Thema Energieeffizienz nicht erst seit heute von hoher Bedeutung für die in globaler Konkurrenz stehende produzierende Industrie. Maschinen- und Anlagenbauer versuchen, von der Nachfrage nach energieeinsparenden Lösungen zu profitieren. Paradoxerweise bleiben die erzielten Umsätze mit innovativen Paketen aus Hard- und Software sowie Services jedoch hinter den Erwartungen zurück. Auch der Versuch, Kunden mit neuen Geschäftsmodellen zu überzeugen, gelingt nicht in einem zufriedenstellenden Masse. Eine globale Befragung von Produktionsunternehmen offenbart die Gründe für dieses Phänomen aus Kundensicht und bietet gleichzeitig Ansatzpunkte, wie bestehende Barrieren durch die Anbieter überwunden werden können.
Thesen zur Konvergenz von Trends und Technologien in der Fabrikplanung
Authors: F. Schäfer Simon , Süße Marian , Ihlenfeldt Steffen
Published: September 2023

Die Fabrikplanung ist ein mehrdimensionales Aufgabengebiet und gegenwärtig mit dem Spannungsfeld aus Nachhaltigkeit, wirtschaftlicher Unsicherheit und kürzeren Technologiezyklen konfrontiert. Es werden kontinuierlich methodische Ansätze entwickelt und technologische Fortschritte in die Planungsprozesse integriert. Folglich entsteht der Eindruck, dass sich aktuelle Schlagworte in diesem Konglomerat zunehmend gegenseitig bedingen. In dem Beitrag werden zunächst diese Zusammenhänge grundlegend beschrieben und aktuelle Forschungstrends analysiert. Daran anknüpfend werden Thesen formuliert, die für eine interessierte Community als Diskussionsgrundlage dienen sollen. Abschließend werden die nächsten vermuteten Schritte zur Konvergenz der Trends und Technologien in der Fabrikplanung sowie zur Ableitung notwendiger Folgeinitiativen beschrieben.
Von der Transaktion zum Wert
Authors: Evcenko Dimitri , Kett Holger , Falkner Jürgen
Published: September 2023

Um ein wertbasiertes Geschäftsmodell im Sinne von Equipment-as-a-Service (EaaS) anbieten und betreiben zu können, muss ein Unternehmen spezifische EaaS-Elemente zu einem EaaS-Angebot zusammenführen. Der vom Fraunhofer-Institut für Arbeitswirtschaft und Organisation IAO entwickelte EaaS-Canvas stellt ein Werkzeug dar, mit dessen Hilfe diese EaaS-Elemente anhand eines strukturierten Vorgehens erarbeitet und visualisiert werden können, wobei die Elemente aus dem Veränderungsbedarf abgeleitet werden, der für Unternehmen entsteht, deren Leistungsangebot bisher ausschließlich auf transaktionsbasierten Geschäftsmodellen aufbaut. Im nachfolgenden Beitrag wird eine kurze Einführung in die einzelnen Elemente des EaaS-Canvas gegeben. Weiter wird die Erarbeitung eines EaaS-Angebots auf Basis des EaaS-Canvas schematisch anhand einer Transformation des transaktionalen Geschäftsmodells von TRUMPF Tracking Technologies (TRUMPF) durchgeführt.
Bewertung und Verbesserung des CO2-Fußabdrucks für PKW-Ladeeinrichtungen
Authors: Werrel Max , Becker Victor , Ehmsen Svenja , Tepper Florian , Glatt Moritz , Aurich Jan C.
Published: September 2023

Die Elektromobilität ist ein wichtiger Baustein für eine klimafreundliche Mobilität. Elektrofahrzeuge, insbesondere in Verbindung mit regenerativ erzeugtem Strom, können deutlich zu einer Reduktion der CO2-Bilanz des Mobilitätssektors beitragen. Im Rahmen einer ganzheitlichen Betrachtung gilt es jedoch, nicht nur das Fahrzeug selbst, sondern auch die notwendige Peripherie möglichst klimaschonend zu gestalten. In diesem Beitrag wird zu diesem Zweck die CO2-Bilanz von Ladeeinrichtungen über deren gesamten Lebenszyklus untersucht und Verbesserungspotenziale aufgezeigt.
Bewertung von Verfahren zum Erreichen von CO2-Negativität in der Produktion
Authors: Eboumbou Ebongue Yvonne , Sauer Alexander
Published: September 2023

Dieser Beitrag beschreibt verschiedene Verfahren zur CO2-Abscheidung aus der Umgebungsluft und zur CO2-Abtrennung aus Abgasen und bewertet sie hinsichtlich ihrer Reinheit, spezifischen Kosten zur CO2-Entfernung sowie des Platzbedarfs. Die betrachteten Verfahren umfassen CO2-Abtrennung aus Abgasen mittels Gaswäsche und Membranverfahren sowie CO2-Abscheidung aus der Umgebungsluft mittels Hochtemperatur- und Niedertemperatur-DAC-Verfahren. Es zeigt sich, dass die Kombination von CO2-Abtrennung aus Abgasen mittels Gaswäsche und gezielte Entfernung historisch emittierten CO2s aus der Umgebungsluft durch das Niedertemperatur-DAC-Verfahren entscheidend ist, um CO2-Negativität in der Produktion zu erreichen.
Feminismo contra a criminalização do aborto
Authors: Da Silva Ribeiro Gomes Simone , Do Prá Alano Roberta
Published: September 2023

O artigo anali

sa as mobilizações de ativistas e coletivos feministas em El Salvador durante a

pandemia de Covid

-

19

–

notadamente no que se refere a direitos sexuais e reprodutivos

–

,

entre 2020 e 2022. O trabalho fez uso de metodologia qualitativa com entrevistas

semies

truturadas, estudo de caso e resgate de dados levantados nas edições do Comunica

América Latina, publicação do Observatório de Movimentos Sociais da América Latina

(OMSAL), entre julho de 2020 e fevereiro de 2022. O estudo de caso se dá a partir de dois

ep

isódios que chamaram a atenção para a situação dos direitos reprodutivos das mulheres

em El Salvador, país em que a proibição total do aborto é rigorosamente aplicada: os casos

Manuela e Beatriz. Duas jovens salvadorenhas expostas a violência obstétrica e

à legislação

antiaborto do país no início dos anos 2000. Os resultados apontam para um esforço dos

movimentos feministas salvadorenhos em resistir, no contexto de distanciamento social,

consequência de medidas sanitárias para combater o coronavírus, às tát

icas políticas

autoritárias do presidente Nayib Bukele. Ademais, as histórias de Manuela e Beatriz

mobilizaram importantes ações coletivas durante o período pandêmico e impactaram a

disputa pelo imaginário social a respeito do aborto no país.
As ruas e as urnas na pandemia
Authors: Henrique da Mota Ferreira Daniel , Luis Moreira Nascimento Jefferson , Nunes Raul
Published: September 2023

O presente artigo procura

analisar o impacto da pandemia na relação entre os movimentos

sociais e as eleições no Equador e no Peru. Baseando

-

se na Teoria do Processo Político (TPP),

o artigo busca comparar, a partir da inflexão da pandemia, as semelhanças e diferenças que

podem hav

er na relação entre movimentos e eleições. Na primeira seção, apresentamos a TPP

e discutimos como as análises da economia política podem ajudar a pensar o

s

estallidos

da

América Latina. Na segunda e na terceira seção, descrevemos os processos políticos do

Equador e do Peru, respectivamente. Na quarta, fazemos a comparação entre os dois casos.

Como conclusão, apontamos que a pandemia acirrou clivagens já existentes, provocou a

indignação coletiva e trouxe um resultado eleitoral de rechaço às forças políticas dominantes em cada país: no Equador, o veto ao correísmo veio de dentro do sistema partidário e pela via

da direita neoliberal junto à falta de maior apoio dos movimentos populares, enquanto no

Peru o veto ao fujimorismo rompeu o quadro partidário existente por meio de um marxismo

improvisado.
POTENCIAL TERAPÊUTICO DE CÉLULAS PROGENITORAS ADULTAS MULTIPOTENTES ALOGÊNICAS NO TRATAMENTO DE APLASIA MEDULAR SECUNDÁRIA À ERLIQUIOSE CANINA
Authors: Jardim Clemente Santos Enrico , Mazzeo Angela , Pozzuto Poppi Fabiana , Landim Braga Camila
Published: September 2023

A aplasia medular é uma doença caracterizada por um quadro no qual a medula óssea passa a ser constituída por uma celularidade inferior a 10%, apresentando uma redução ou ausência dos três tipos celulares (eritróide, mielóide e megacariocítica). No presente estudo, as células progenitoras adultas multipotentes, isoladas a partir da polpa dentária de cão saudável (CPAMs-PDC), foram analisadas com base em sua morfologia, potencial de proliferação e diferenciação adipogênica, osteogênica e condrogênica sendo posteriormente criopreservadas. Foram realizadas três aplicações de 6 x 106 CPAMs-PDC, com intervalos de trinta dias, em doze pacientes acometidos por um quadro de aplasia medular, sendo três Schnauzers, dois Beagles, três Bulldogs e quadro SRDs. O grupo de animais foi composto por 8 machos e 4 fêmeas, com idades entre 2 e 6 anos e peso entre 10 e 23 kg. Duas das aplicações foram realizadas pela via intravenosa e uma pela via intramedular. Os resultados demonstraram uma resposta medular, com elevação da porcentagem do hematócrito até a estabilidade total da medula. Nesse sentido, este estudo sugere que em casos de aplasia mielóide derivada do quadro de erliquiose, a terapia com células-tronco se apresenta extremamente promissora.
KIAA1429/VIRMA promotes breast cancer progression by m6A‐dependent cytosolic HAS2 stabilization
Authors: Li Na , Zhu Zhouting , Deng Yufei , Tang Rachel , Hui Hui , Kang Yuqi , Rana Tariq M
Published: September 2023

N6‐methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, plays important roles in many physiological and pathological processes, including the development and progression of cancer. RNA modification by m6A is regulated by methyltransferases, demethylases, and m6A‐binding proteins that function in large part by regulating mRNA expression and function. Here, we investigate the expression of m6A regulatory proteins in breast cancer. We find that expression of KIAA1429/VIRMA, a component of the m6A methyltransferase complex, is upregulated in breast cancer tissue and correlates positively with poor survival. KIAA1429/VIRMA is mislocalized to the cytosol of breast cancer tissues and cell lines, and shRNA‐mediated knockdown inhibits breast cancer cell proliferation, migration, and invasion. Mechanistically, KIAA1429/VIRMA is shown to bind to the m6A‐dependent RNA‐binding protein insulin‐like growth factor 2 mRNA‐binding protein 3 (IGF2BP3), leading to recruitment and stabilization of m6A‐modified hyaluronan synthase 2 (HAS2) mRNA. HAS2 mRNA and KIAA1429/VIRMA mRNA levels correlate positively in breast cancer tissues, suggesting that the KIAA1429/VIRMA–IGF2BP3–HAS2 axis promotes breast cancer growth and contributes to poor prognosis.
Morphological Variation of Rafflesia zollingeriana Koord. and its Recent Distribution in East Java, Indonesia
Authors: Lestari Dewi , Susatya Agus
Published: September 2023

Locals in Lumajang have reported the growth of Rafflesia in Tempursari and Pasirian. Because species identification is fundamental for ecological monitoring, this study aims to identify species and record its geographical distribution. The Rafflesia at two locations were identified as R. zollingeriana after observing the specimens at the site and comparing them to herbaria from THBB and PHPB. This signifies that the distribution of R. zollingeriana in East Java has been updated. R. zollingeriana was formerly thought to only exist in conservation areas like Meru Betiri National Park and Watangan Nature Reserve, but this research demonstrates that it also exists outside of these protected/conservation areas. Only hills and steep cliffs are home to R. zollingeriana in Lumajang. This extremely limited and tough environment is assumed as a result of the conversion of forests into agricultural plantation, which only remained these sites for R. zollingeriana to grow. In order to prevent R. zollingeriana extinction in these areas, conservation strategies are required. This study offers conservation strategy recommendations, both in situ and ex situ. These recommendations expected could be used to establish a long-term conservation strategy for East Java's Rafflesia.
Inventaritation and Potential Utilization of Macroscopic Mushroom in TPKh Tenjo KPH Bogor
Authors: Alfatinnisa Zalfa , Mahardhika Wahyu Aji , Lunggani Arina Tri , Putra Ivan Permana
Published: September 2023

The TPKh Tenjo KPH Bogor is a production forest wood collection area and becomes a production forest for the Acacia mangium wood species. Timber harvesting activities leave a lot of tree stumps, twigs, or piles of wood that do not pass production. Environmental conditions with a lot of harvested wood residue and supported by relatively cool air temperatures and high humidity, it is suspected this area has a diversity of macroscopic fungi with various unknown potentials. This study aims to obtain data on the types of macroscopic fungi and their potential uses. The research method includes the stages of exploration, identification and literature study to obtain the potential of the macroscopic fungi found. The research succeeded in finding 8 types of macroscopic fungi classified into the phylum Basidiomycota, 3 orders, 5 families, and 7 genera. The macroscopic fungi include Coprinellus sp., Lentinus sp., Panus sp., Schizophyllum commune, Pycnoporus sp., Fomitopsis sp. 1, Fomitopsis sp. 2, and Lycoperdon sp. Based on the results of the literature study, the potential uses of macroscopic fungi were found are as food, medicine, natural pigment producer, and enzyme producer.  This data report can be used as basic information on the use of macroscopic mushrooms by communities around the area to be used as food or medicinal ingredients. Further utilization of this data is the development of the potential of macroscopic fungi that produce enzymes, pigments or drugs to be produced on a large scale. Research on the development of potential mushroom conservation strategies can also be carried out for sustainable use.
Effect of Green Tea Extract on Spermatozoa Quality of Peranakan Ongole Bull On Frozen Storage
Authors: Pramesti Giyanita Rahma Ayu , Ducha Nur
Published: September 2023

Low-temperature storage can often result in spermatozoa damage. It occurs due to Reactive Oxygen Species, leading to changes in the lipid composition of the membrane. Antioxidant compounds are needed to prevent ROS. Green tea extract (Camelia sinensis) can be used as an antioxidant agent. This study aimed to determine the effect of green tea extract in tris egg yolk on spermatozoa quality of Ongole Peranakan (PO) cattle. This study used a completely randomized design (CRD) with five extract treatments (0%, 1%, 2%, 3%,4%) and four repetitions. The parameters used were motility, viability, and membrane integrity. The data were analyzed with ANOVA and Duncan's test. Based on the results of the ANOVA test, the addition of green tea extract has a significant effect on spermatozoa quality of PO cattle in frozen storage (P0.005). The best results were obtained by the addition of 3% extract that was able to maintain the quality of post-freezing spermatozoa with average motility, viability, and membrane integrity of 47.44±0.166, 55.14±0.449, and 53.72±0.599. The addition of 3% green tea extract into tris egg yolk can maintain motility, viability, and membrane integrity in spermatozoa of PO cattle inside frozen storage, by adding green tea extract to diluent, spermatozoa can be stored for a long time at low temperatures making it easier for people to carry out artificial insemination.
Rat Liver Function Induced By A High-Fat Diet After Giving Mahogany Seeds Ethanol Extract
Authors: Sijabat Agave Chintya Gabriella , Isdadiyanto Sri , Sitasiwi Agung Janika
Published: September 2023

Intake of a high-fat diet can cause hyperlipidemia which increases the rate of triglycerides and cholesterol, and decrease the HDL levels. The increase of lipid levels in the blood can cause Non-Alcoholic Fatty Liver Disease (NAFLD) which triggers damage of liver function. Mahogany seeds have bioactive compounds that have the potential to be antioxidants in treating hyperlipidemia. This study aimed to analyze the liver function of rats by inducing a high-fat diet after giving mahogany seeds ethanol extract which was observed through the levels of SGOT and SGPT. Thirty male rats of the Sprague Dawley strain were divided into 6 groups of treatment, that were: P0 (only given commercial feed), P1 (given a high-fat diet), P2 (given a high-fat diet and simvastatin at a dose of 8 mg/200 g BW), P3, P4, and P5 (given a high-fat diet and mahogany seeds ethanol extract of 14, 28, and 56 mg/200gBW). The results showed that there was no significant difference between all treatment groups. Administration of mahogany seeds ethanol extract was able to prevent the increase of SGOT and SGPT levels. Mahogany seeds ethanol extract has the hepatoprotective effect against high-fat diet induced hepatotoxicity, thereby affirming its traditional therapeutic role in liver injury.
Callogenesis of Dayak Onion (Eleutherine palmifolia) Bulb in response of Picloram, 2,4-D, and Kinetin
Authors: Habibah Noor Aini , Lutfiah Ananda , Liana Alin , Sri Tunjung Woro Anindito , Indrowati Meti , Pa’ee Furzani
Published: September 2023

Dayak onion contains bioactive compounds that are traditionally used for medicine. The production of bioactive compounds can be increased through callus culture. This study aims to analyze the effect of the combination of plant growth regulator on the growth of Dayak bulb callus. The design of this study used a completely randomized factorial design with 2 factors. The first factor is the concentration of auxin. While the second factor is the concentration of kinetin. The parameters observed include the percentage of callus, the time of callus formation, fresh weight, dry weight, and callus morphology. In this study, a callus growth curve was also made to determine the best harvest time. The results showed that highest callus fresh weight was obtained in the P3K1 treatment. The percentage of callus formation in the picloram + kinetin treatment was higher than in the 2,4-D + kinetin treatment. The time of callus formation occurred in the combination of picloram + kinetin faster than the 2.4-D + kinetin treatment. The callus color is diverse,  while the texture of the entire callus is compact. The best callus induction medium for Dayak onion bulbs is to use picloram 2-4 ppm + kinetin0.025-0.5 ppm. The results of this study provide optimal growth regulatory information for the induction of dayak onion callus that has never been reported before. This information can be the basis for the development of methods of production of bioactive compounds from dayak onions through callus culture.
Cardiovascular Disease and COVID-19 Vaccines: A Systematic Review and Analysis of Published Cases
Authors: Khaity Abdulrhman , Rababah Ala’ Abdala Mohamad , Abdelwahab Omar A , Albakri Khaled , Diab Rehab Adel , Al-dardery Nada Mostafa , Abbassy Mahmoud , Al-Hanaqtah Balqees M , Awad Ahmed K , Mohamad Tamam
Published: September 2023

As vaccination against COVID-19 became more widespread, side-effects that were not initially detected during clinical trials became more prominent. The aim of this systematic review is to discuss reports of adverse cardiovascular events associated with COVID-19 vaccination. Databases were searched from inception up to August 2022 to identify case reports and case series reporting on patients with cardiovascular disease after COVID-19 vaccination. This study assessed 150 published cases. Of these, 109 were case reports and 41 were case series. The majority of patients were male (n=302, 86.6%), with a mean age of 27.6 ± 16.7 years. Of the included patients, 268 (76.6%) had myocarditis, 50 (14.6%) had myopericarditis, 8 (2.3%) had pericarditis, and only 4 (1.1%) had stress-induced cardiomyopathy. Moreover, 30 (8.6%) and 11 (3.1%) were diagnosed with arrhythmia and ischaemic heart disease, respectively. Ultimately, cardiovascular complications after COVID-19 vaccination include myocarditis, myopericarditis, ischaemic heart disease and arrhythmia. The young population, especially young male patients, could be more vulnerable to myocarditis.
On Hardy and Hermite-Hadamard inequalities for $N$-tuple diamond-alpha integral
Authors: Mao Zhong-xuan , Zhang Wen-bin , Tian Jing-feng
Published: September 2023

In this paper, we aim to construct $n$ dimensional Jensen, Hardy and Hermite-Hadamard type inequalities for multiple diamond-alpha integral on time scales. The cases of Hardy type inequality with a weighted function and Hermite-Hadamard type inequality with three variables are also considered minutely.
Curious harmony in asymmetric & nonlinear variant of Filbert and Lilbert matrices
Authors: Kılıç Emrah , Ersanlı Didem
Published: September 2023

In this paper, we present a new analogue of the Filbert and Lilbert matrices whose indices have different asymmetric and nonlinear rules according to their row numbers. Explicit formulae are derived for the $LU$-decompositions, their inverses and the inverse of the main matrix as well as its determinant. To prove the claimed results we use backward induction method. The asymmetric variants of the Filbert and Lilbert matrices are obtained from our results for a particular $q$ value.
Certain topological properties for almost convergent Catalan-Motzkin sequence space
Authors: Dağlı Muhammet Cihat
Published: September 2023

The purpose of this paper is to introduce a new almost convergent sequence space by means of a matrix involving Catalan and Motzkin numbers. It is demonstrated that this novel sequence space and the space of all almost convergent sequences are linearly isomorphic and the $\beta$-dual of this new space is deduced. In addition, by defining Catalan-Motzkin core of a complex-valued sequence, certain inclusion relations are derived for it.
DO ESPAÇO AO LUGAR
Authors: Yllas Yayenca  Frachia , Tozato Heloisa de Camargo , Firmo Heloisa Teixeira
Published: September 2023

O presente artigo parte da premissa da importância que têm os coletivos na construção de um novo espaço pedagógico. O texto foi elaborado a partir de um recorte do estudo de caso realizado na Escola Municipal Pedro Ernesto, localizada no bairro da Lagoa, no Rio de Janeiro, Brasil. A investigação objetiva a análise crítica e reflexiva do processo de apropriação e do sentimento de pertencimento na construção coletiva da horta pedagógica agroecológica da unidade escolar. As sequências didáticas foram desenvolvidas entre maio de 2021 e maio de 2023. O conjunto metodológico foi centralizado na pesquisa-ação, complementado por rodas de conversa. Contou com a participação direta de 350 estudantes pertencentes a 9 turmas do 1° ao 5° ano do Ensino Fundamental I, 10 docentes, 1 coordenadora pedagógica, 2 diretoras, 2 agentes educacionais, 3 merendeiras, 2 pessoas de manutenção e 1 pesquisadora. Para a coleta de resultados, foram utilizadas as entrevistas semiestruturadas e a sistematização de sentimentos das crianças por meio de nuvens de palavras produzidas coletivamente. Observou-se, ao longo da construção coletiva na horta, que as/os estudantes foram ganhando seu próprio lugar, tendo voz e autonomia, gerando um sentimento de cuidado, carinho e identidade, pois o espaço lhes pertence. Esse sentimento favoreceu a consolidação e a real introjeção do aprendizado, estimulando os fazeres-saberes.
PERIFERIA EM FOCO
Authors: Conceição Deise Guilermina da
Published: September 2023

O presente artigo tem como principal temática as reflexões de estudantes de uma escola que oferta os anos finais do ensino fundamental e que atende aos alunos moradores de uma favela de um bairro da periferia carioca. A maior parte do corpo discente é formada por estudantes pretos e pardos, que durante muito tempo não enxergaram a escola enquanto território. Na narrativa que segue, traremos os debates insurgentes que se deram entre discente e alunos de uma das turmas da escola sobre racismo e discriminação racial e as ideias acerca de hierarquias entre os grupos humanos, tendo o branco caucasiano como padrão e os demais grupos étnicos como negros e indígenas posições subalternas. Nesse contexto, esse artigo tem como principal temática, analisar os desdobramentos da supervalorização da estética de matriz europeia na identidade de estudantes de escolas públicas do estado do Rio de Janeiro, situadas nas periferias da região metropolitana do estado. Assim, temas como negritude, periferia, estética e juventude permearam os relatos dos estudantes e revelaram um processo educativo que reinventa não apenas o pertencimento e a ocupação do espaçotempo da escola pelos estudantes, como também a perenidade das lutas antirracistas no Brasil. A reflexão que segue contribui para produção de ações mais horizontalizadas e para uma ecologia dos saberes que emerge das práticas que vêm permitindo o reencantamento do mundo por essa comunidade interpretativa.
State-Business Relations and Arenas as a Legitimate Space for State-Corporate Crimes: The Case of Modern Slavery in Brazil
Authors: Paganini Paulo , Medeiros Cintia Rodrigues de Oliveira
Published: September 2023

This article aims to explore the genesis of arenas as an interorganizational relation space that can promote, or at least cleave, the path for corporate crimes. Based the scenario in which Brazil eradicated slavery, we argue there has been the creation of dynamic arenas and counter-arenas as spaces for avoiding or promoting corporate crimes, while the state has played the role of facilitator in such crimes. This paper asserts that promotion and prevention of corporate crimes are both legitimate actions by the state in its regime of permission, and every single actor who play in this field through arenas. In order to map the key elements of these arenas, our investigation is based on the techniques of shadowing, in-depth interviews, and field observation. After building our data pool, we analysed the phenomena mostly through open, axial, and selective coding, based on the Grounded Theory approach as a mean for categorization.
Modern approaches to auditing the quality and safety of agricultural products
Authors: Shibarshina Olʹga , Lyashchuk Yuliya
Published: September 2023

The article reflects the results of audits of the quality and safety of dairy raw materials from farms-suppliers in the Ryazan region in 2021. To assess the degree of influence of the animal morbidity factor on the quality of milk, an analysis was made of the main indicators of raw milk obtained from suppliers of the Starozhilovsky Dairy Plant. Like all natural products, milk and dairy products are a breeding ground for the growth and development of microorganisms. Of course, dairy products normally contain certain standards for the number of microorganisms of various etiologies (the total number of bacteria). As practical production experience shows, even with an acceptable quantitative level of microorganisms, there is a risk of a decrease in the quality of milk and dairy products under the negative influence of a certain number of factors. A risky situation can be realized at any stage of the production-consumption cycle. At the same time, the highest level of risk exists from the moment of milking to the beginning of the processing process and the receipt of finished products. At subsequent stages, the biological risks of spoilage of dairy products are significantly reduced due to the positive impact of technological processes. Currently, dairy cattle breeding is one of the most rapidly developing sectors of the national economy. The efficiency of milk production depends on many factors, including the health, general well-being and milk production of animals. In a positive way, the above factors are influenced by comfortable conditions for keeping and feeding animals. A balanced diet is the basis for the health and milk productivity of cattle. Also, one of the important activities is to conduct audits of the quality and safety of dairy raw materials in supplier farms, which are discussed in detail in this paper using the example of dairy cattle breeding. The article considers the main indicators of the quality and safety of dairy products, assesses the impact of the animal morbidity factor on the quality of raw milk, compiled an up-to-date list of biopathogens that are significant in the production and processing of milk and dairy products.
Implementation of design solutions for the creation of an automated information system for monitoring the movement of raw materials in the warehouse of an industrial enterprise
Authors: Movchan Irina , Belousova Irina , Starkov Alexander , Trofimov Evgeny
Published: September 2023

The article presents one of the possible solutions to the problem of controlling the movement of raw materials in the warehouse of an industrial enterprise. The relevance of the study is determined by the need to improve the management of material and information flows of the enterprise. One of the important directions is to increase the efficiency of operations management in the warehouse of an industrial enterprise. The solution to the problem is proposed by designing an automated information system for monitoring the receipt and movement of raw materials in the warehouse, which will allow you to monitor the process of receiving and storing raw materials, store and analyze data for any period of time, and search for the necessary information according to various selection criteria. The article substantiates the relevance of creating and implementing an automated information system in the activities of enterprises in order to increase their competitiveness. The introduction of an automated information system will provide an opportunity to reduce management costs by freeing up human resources and maintaining operational records of business transactions. Considering the possibility of integrating modules of ready-made solutions for the introduction of an automated raw material accounting system at an enterprise, the authors carried out a comparative analysis of some workflow automation systems. The study is based on a general scientific methodology, which provides for the application of a systematic approach to solving problems of improving the manageability of an enterprise. In this regard, the methodologies of structural and object-oriented approaches to the analysis, design and implementation of design solutions were used as research methods. The authors in the paper presented in detail a description of the key modules of the automated system for controlling the movement of raw materials in the warehouse. The results of the study can be used to develop recommendations for improving the activities of the warehouse of a manufacturing enterprise.
Key features of the analysis of financial risks of a gas producing enterprise
Authors: Serov Sergey
Published: September 2023

In this article, the author considers the problem of financial risks of organizations. In more detail, this topic is revealed by him on the example of PJSC Gazprom. First of all, the author draws attention to the fact that the category of risk can be interpreted in different aspects, and gives examples of the definition of the concept of "risk", including according to GOST. In the process of considering the theoretical aspects of the risk management system, the author identifies the goals that are universal for each company in this system. In addition, the article formulated the concept of economic risks and analyzed their essence. The table compiled by the author indicates the main types of economic risks and their description. In addition, other classifications of types of risk are given and their distinctive features are indicated. Further, the author proceeds to consider the risk management system operating in Gazprom: its main goal and a number of main tasks are indicated. For a clearer understanding, the author presents a risk management scheme at PJSC Gazprom. The author also compiled a risk map of the company to identify its weakest points. For a broader analysis of the selected problem, an assessment is made of the company's maximum exposure to credit risk in the period from 2020 to 2022. the dynamics of credit debt and loans of the company for the same period is analyzed. Based on the data obtained, expressed in the form of tables, the author comes to the conclusion that the need to develop new directions and risk management and risk assessment methods is quite acute in PJSC Gazprom.
The impact of the development of the world monetary fund on international financial and economic relations
Authors: Samusevich Vladimir , Akhmetov Minnegaley
Published: September 2023

This article raises the issue of the development of the world currency market, as well as its influence on the development of international economic relations. For a deeper understanding of this problem, the author first of all considers the concept of a monetary and financial organization, the direction of its activities and lists the leading international monetary and stock organizations, namely: the IMF, WTO, World Bank. Further, the author proceeds to a more detailed consideration of these currency and stock organizations: their functions, goals and objectives are analyzed, the structure of organizations is indicated, and historical information is given. The author also draws attention to the fact that there are special currency and stock organizations whose activities are aimed at regulating the debts of foreign borrowers (for example, the London and Paris Club of creditor banks). The author comes to the conclusion that it is thanks to the functioning of currency and stock organizations that the regulation of credit activities, trade relations between countries, their debts and financial flows between them is carried out. The author then proceeds to consider the International Monetary Fund. The article provides the history of the emergence of this organization, the share of the authorized capital. In addition, the author examines the current structure of the IMF, its functions. Particular attention is paid to the role of the IMF in currency regulation. Within the framework of this aspect, the concept of SDR (special drawing rights), its course and purpose is revealed. The role of the IMF in providing
short-term and medium-term loans in case of a deficit in the state's balance of payments is considered in more detail. Such aspects as the reserve share and its size, credit shares and its framework, stand-by stand-by loans are analyzed. In the final part, the author summarizes the importance of the world currency market in the global economy and international relations.
Motion velocity as a preattentive feature in cartographic symbolization
Authors: Cybulski Paweł , Krassanakis Vassilios
Published: September 2023

The presented study aims to examine the process of preattentive processing of dynamic point symbols used in cartographic symbology. More specifically, we explore different motion types of geometric symbols on a map together with various motion velocity distribution scales. The main hypothesis is that, in specific cases, motion velocity of dynamic point symbols is the feature that could be perceived preattentively on a map. In a controlled laboratory experiment, with 103 participants and eye tracking methods, we used administrative border maps with animated symbols. Participants’ task was to find and precisely identify the fastest changing symbol. It turned out that not every type of motion could be perceived preattentively even though the motion distribution scale did not change. The same applied to symbols’ shape. Eye movement analysis revealed that successful detection was closely related to the fixation on the target after initial preattentive vision. This confirms a significant role of the motion velocity distribution and the usage of symbols’ shape in cartographic design of animated maps.
LAPAROSKOPİK ADRENALEKTOMİ’DE PREOPERATİF DEMOGRAFİK VE KLİNİK ÖZELLİKLERİN POSTOPERATİF KOMPLİKASYONLAR ÜZERİNDEKİ ETKİSİ
Authors: BAYLAN Burhan , UZUN Recep
Published: September 2023

Amaç

Laparoskopik adrenalektomi (LA), primer aldosteronizm (PA) veya Cushing sendromu (CS) ile ilişkili olanlar da dahil olmak üzere küçük benign adrenal tümörlerin cerrahi tedavisinde altın standarttır. LA’da, postoperatif dönem komplikasyonlar ile başta vücut kitle indeksi olmak üzere diğer özelliklerin ilişkisini araştırmayı planladık.

Gereç ve Yöntemler

Kliniğimizde adrenalektomi yapılan 47 hasta retrospektif incelendi. Hastaların tümünde preoperatif Vucut Kitle İndeksinin (VKİ) içinde bulunduğu demografik özellikler, İntraoperatif verilerde işlem yaklaşımı, kitle tarafı, kitle boyutu, operasyon süresi ve hesaplanan kan kaybı değerleri kaydedildi. Postoperatif veriler erken ve geç komplikasyonlara dair Modifiye Clavien-Dindo dereceli komplikasyonların sınıflandırılmasını içermektedir.

Bulgular

LA uygulanan hastaların %31.91'i erkek (n=15) idi. Ortalama yaş 53,4 idi. Ortalama VKİ 24,15(20,2-28,9) kg/m2 idi. VKİ normal (18,5-24,9 kg/m2 ) olan 16 hasta, VKİ kilolu olan (25-29 kg/m2 ) 31 hasta mevcuttu. Postoperatif dönem komplikasyonlar Modifiye Clavien-Dindo sınıflamasına Grade 1 %70,2; Grade 2 %23,4, Grade 3%0,2, Grade 4 %0,4 olarak bulundu. Ortalama hastanede kalış süresi 2,91(1-5) gündü. VKI kilolu olan hastalarda, VKI normal olan hastalara göre Grade 2 komplikasyon görülme riski istatistiksel olarak daha fazlaydı.

Sonuç

LA endikasyonu olan ve VKI kilolu (25-29 kg/m2 ) grupta yer alan hastalarda Clavıan Dındo grade 2 komplikasyon gelişme riski yüksek olması nedeniyle postoperatif dönemde yakın takip edilmedir.
AN ECOFEMINIST ANALYSIS OF MARY SHELLEY’S MATHILDA: THE FEMALE NARRATOR WRITING HER OWN TABOO FICTION
Authors: KARABULUT Tuğba
Published: September 2023

Re-reading Mary Wollstonecraft Shelley’s novelette, Mathilda, in the twenty-first century from an ecofeminist perspective sheds a new light on contemporary criticism, opening up multifaceted perspectives. There was a critical moment in British literary history when Elizabeth Nitchie transcribed Mathilda from the microfilm of the manuscript and published it in 1959, which unveiled this piece of revolutionary taboo fiction suppressed for over a century by the author’s male relatives, chiefly Shelley’s father, William Godwin. Written in 1819-1820, Mathilda is the only work completed during Shelley’s lifetime. It is an artfully crafted epistolary work depicting the traumatic confessions and suicidal tendencies of the protagonist, Mathilda, a woman who isolated herself from society by integrating herself with nature due to her father’s confession for his incestuous passion towards her. Regarded as an underrated work, Mathilda has often been interpreted from biographical and incest-related perspectives by literary critics, which relegates its literary merits although it is in accordance with feminist and ecological theories and feminine writing. This paper, avoiding biographical accounts and the author’s life experiences and with theories consistent with those of ecofeminism, intends to show how nature functions as an effective instrument for the female writer to fictionalize her taboo story. By blending ecofeminism with feminine writing, this paper also investigates the interplay between woman and nature, and navigates how a female character courageously relocates her taboo story on a textual level from a feminist perspective in a natural setting, challenging the male-dominant Romantic tradition of the nineteenth century.
HABER MEDYASI OKURYAZARLIĞI DÜZEYLERİNİN İNCELENMESİ: ÇUKUROVA ÜNİVERSİTESİ ÖRNEĞİ
Authors: ATEŞGÖZ Kenan
Published: September 2023

Çalışmada lisans öğrencilerinin haber medyası okuryazarlık düzeylerinin belirlenmesi amaçlanmaktadır. Çalışmanın örneklemini Çukurova Üniversitesi’nde eğitim gören 633 lisans öğrencisi oluşturmaktadır. Bu doğrultuda, çalışmada, Haber Medyası Okuryazarlığı Ölçeği veri toplama aracı olarak kullanılmıştır. Haber medyası okuryazarlık düzeylerinin belirlenmesi için kümeleme analizi tekniklerinden biri olan k-ortalamalar analizi, çeşitli değişkenlere göre incelenmesinde ise bağımsız örneklemler için t-testi ve tek faktörlü ANOVA kullanılmıştır. K-ortalamalar analizi sonuçları katılımcıların öz yeterlik düzeylerinin yüksek, eleştirel performans düzeylerinin düşük, genel haber medyası okuryazarlık düzeylerinin ise orta düzeyde olduğunu göstermiştir. Katılımcıların haber medyası okuryazarlık düzeylerinin cinsiyet ve aylık gelir düzeyine göre farklılık göstermediği ancak öğrenim görülen fakülte ve haber takibinde kullanılan medya aracına göre değiştiği bulgulanmıştır. Araştırma bulguları, Tıp ve Mühendislik Fakülteleri’nde öğrenim gören öğrencilerin haber medyası okuryazarlık düzeylerinin benzer ve diğer fakültelerde (Eğitim, Fen-Edebiyat, Hukuk, İletişim, İktisadi ve İdari Bilimler) öğrenim gören öğrencilerden daha düşük olduğunu ortaya koymaktadır. Ayrıca, Telegram, Twitter ve YouTube platformlarını kullanan lisans öğrencilerinin haber medyası okuryazarlık düzeylerinin benzer, haber sitesi-dijital gazete ve Instagram platformunu kullananlardan ise yüksek olduğu sonucuna ulaşılmıştır.