bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigation of How Corneal Densitometry Artefacts Affect the Imaging of Normal and Keratoconic Corneas
Authors: Alanazi Rami , Esporcatte Louise Pellegrino Gomes , White Lynn , Salomão Marcella Q. , Lopes Bernardo T. , Ambrósio Jr. Renato , Abass Ahmed
Published: February 2024

Purpose: To investigate corneal densitometry artefacts found in Pentacam Scheimpflug scans and their potential effect on assessing keratoconic (KC) corneas compared to normal (N) corneas. Methods: The current study utilises Pentacam data of 458 N eyes, aged 35.6 ± 15.8 (range 10–87), referred to as the “N group”, and 314 KC eyes, aged 31.6 ± 10.8 (range 10–72), referred to as the “KC group”, where densitometry data were extracted and analysed via a custom-built MATLAB code. Radial summations of the densitometry were calculated at diameters ranging from 0.5 mm to 5.0 mm. The minimum normalised radial summation of densitometry (NRSD) value and angle were determined at each diameter and then linked. KC cone locations and areas of pathology were determined, and a comparison between N and KC groups was carried out both within the averaged area of pathology and over the corneal surface. Results: Joining minimum NRSD trajectory points marked a clear distortion line pointing to the nasal-superior direction at 65° from the nasal meridian. The findings were found to be independent of eye laterality or ocular condition. Consistency was detected in the right and left eyes among both the N and KC groups. The location of the KC cone centre and the area of pathology were determined, and the densitometry output was compared both within the area of pathology and over the whole cornea. When the average densitometry was compared between N and KC eyes within the KC area of pathology, the N group recorded a 16.37 ± 3.15 normalised grey-scale unit (NGSU), and the KC group recorded 17.74 ± 3.4 NGSU (p = 0.0001). However, when the whole cornea was considered, the N group recorded 16.71 ± 5.5 NGSU, and the KC group recorded 15.72 ± 3.98 NGSU (p = 0.0467). A weak correlation was found between the Bad D index and NGSU when the whole measured cornea was considered (R = −0.01); however, a better correlation was recorded within the KC area of pathology (R = 0.21). Conclusions: Nasal-superior artefacts are observed in the densitometry Pentacam maps, and analysis shows no significant differences in their appearance between N or KC corneas. When analysing KC corneas, it was found that the cone positions are mostly on the temporal-inferior side of the cornea, opposite to the densitometry artefact NRSD trajectory. The analysis suggests that the corneal densitometry artefacts do not interfere with the KC area of pathology as it reaches its extreme in the opposite direction; therefore, weighting the densitometry map to increase the contribution of the inferior-temporal cornea and decreasing that of the superior-nasal area would improve the classification or identification of KC if densitometry is to be used as a KC metric.
Estimation of Validity of A-Mode Ultrasound for Measurements of Muscle Thickness and Muscle Quality
Authors: Lee Ji-Won , Hong Seung-Ug , Lee Ju-Hee , Park Sung-Yun
Published: February 2024

This study aimed to determine whether amplitude modulation (A-mode) ultrasound (US) provides accurate and reliable measurements comparable to those obtained using brightness modulation (B-mode) US under diverse conditions. Thirty healthy participants (15 women and 15 men) underwent measurements of subcutaneous fat thickness (SFT), muscle thickness (MT), and muscle quality (MQ) in the trapezius and biceps brachii muscles using both US modes before and after exercises designed to stimulate the respective muscles. Among the three key indices, the results demonstrated the high validity of the A-mode, with minimal mean differences (MDs) between the two devices less than 0.91 mm and intra-class correlation coefficients (ICCs) exceeding 0.95 for all measures. In addition, the correlation coefficients between the error scores and average scores for the trapezius and biceps brachii suggested no evidence of systematic error. The trapezius MT and MQ significantly increased, and the biceps brachii MT significantly increased after the exercises (p < 0.05). Notably, both the A- and B-modes exhibited the same trend in these post-exercise changes in the muscle. This study suggests that low-cost and low-resolution A-mode US provides measurements of SFT, MT, and MQ similar to the more expensive, high-resolution B-mode imaging. A-mode US is an affordable and portable alternative for muscle assessment.
The Omicron XBB.1 Variant and Its Descendants: Genomic Mutations, Rapid Dissemination and Notable Characteristics
Authors: Giancotti Raffaele , Lomoio Ugo , Puccio Barbara , Tradigo Giuseppe , Vizza Patrizia , Torti Carlo , Veltri Pierangelo , Guzzi Pietro Hiram
Published: February 2024

The SARS-CoV-2 virus, which is a major threat to human health, has undergone many mutations during the replication process due to errors in the replication steps and modifications in the structure of viral proteins. The XBB variant was identified for the first time in Singapore in the fall of 2022. It was then detected in other countries, including the United States, Canada, and the United Kingdom. We study the impact of sequence changes on spike protein structure on the subvariants of XBB, with particular attention to the velocity of variant diffusion and virus activity with respect to its diffusion. We examine the structural and functional distinctions of the variants in three different conformations: (i) spike glycoprotein in complex with ACE2 (1-up state), (ii) spike glycoprotein (closed-1 state), and (iii) S protein (open-1 state). We also estimate the affinity binding between the spike protein and ACE2. The market binding affinity observed in specific variants raises questions about the efficacy of current vaccines in preparing the immune system for virus variant recognition. This work may be useful in devising strategies to manage the ongoing COVID-19 pandemic. To stay ahead of the virus evolution, further research and surveillance should be carried out to adjust public health measures accordingly.
Novel Apoplastic Antifreeze Proteins of Deschampsia antarctica as Enhancer of Common Cell Freezing Media for Cryobanking of Genetic Resources, a Preliminary Study
Authors: Short Stefania E. , Zamorano Mauricio , Aranzaez-Ríos Cristian , Lee-Estevez Manuel , Díaz Rommy , Quiñones John , Ulloa-Rodríguez Patricio , Villalobos Elías Figueroa , Bravo León A. , Graether Steffen P. , Farías Jorge G.
Published: February 2024

Antifreeze proteins (AFPs) are natural biomolecules found in cold-adapted organisms that lower the freezing point of water, allowing survival in icy conditions. These proteins have the potential to improve cryopreservation techniques by enhancing the quality of genetic material postthaw. Deschampsia antarctica, a freezing-tolerant plant, possesses AFPs and is a promising candidate for cryopreservation applications. In this study, we investigated the cryoprotective properties of AFPs from D. antarctica extracts on Atlantic salmon spermatozoa. Apoplastic extracts were used to determine ice recrystallization inhibition (IRI), thermal hysteresis (TH) activities and ice crystal morphology. Spermatozoa were cryopreserved using a standard cryoprotectant medium (C+) and three alternative media supplemented with apoplastic extracts. Flow cytometry was employed to measure plasma membrane integrity (PMI) and mitochondrial membrane potential (MMP) postthaw. Results showed that a low concentration of AFPs (0.05 mg/mL) provided significant IRI activity. Apoplastic extracts from D. antarctica demonstrated a cryoprotective effect on salmon spermatozoa, with PMI comparable to the standard medium. Moreover, samples treated with apoplastic extracts exhibited a higher percentage of cells with high MMP. These findings represent the first and preliminary report that suggests that AFPs derived from apoplastic extracts of D. antarctica have the potential to serve as cryoprotectants and could allow the development of novel freezing media.
Biomarkers of Innate Immunity and Immunological Susceptibility to Viral Infection in Patients with Alcoholic Cirrhosis
Authors: Legaz Isabel , Navarro-Noguera Elena , Collados-Ros Aurelia , Bolarín Jose Miguel , Muro Manuel
Published: February 2024

Background: The harmful effect of alcohol on the immune system may be due to both a direct action of the alcohol or its metabolites on immune cells as an indirect action modifying the different mechanisms of intercellular interaction. The interplay between stimulatory (aKIR) and inhibitory (iKIR) natural killer (NK) cell receptors and their corresponding human leukocyte antigen (HLA) ligands influences the outcome of virus infection. The aim was to analyze the influence of the KIR/HLA pair genetic profile in male alcoholic cirrhosis (AC) patients with and without viral infections to find susceptibility biomarkers that can help establish the risks and prevent viral infections. Methods: A total of 281 male AC patients were analyzed. The sociodemographic characteristics, viral hepatitis C (HCV), hepatitis B (HBV), and cytomegalovirus (CMV) infections were analyzed. Genomic DNA was extracted, and genetic the KIR/HLA profiles were investigated. A total of 6 KIR genes and their corresponding ligands (HLA-C) were analyzed. Patients were grouped into two groups: with and without associated viral infection. Results: A statistically significant increase in the combination of KIR2DL2+/C1C1 was observed in male AC patients with viral infection compared to those without viral infection (45.9% vs. 24.5%, p = 0.021). The analysis of KIR2DL3+/C1+ showed a high frequency comparing healthy controls and male AC patients without virus infection (85% vs. 76.4%; p = 0.026). The analysis of KIR2DL3+/C2C2 frequency showed a statistically significant increase comparing male AC patients without viral infection and healthy controls (23.6% vs. 15%; p = 0.026). Conclusions: The genetic KIR2DL2+/C2C2 profiles may play a significant role in determining the vulnerability of male AC patients to viral infections, providing valuable insights for future research and potential therapeutic interventions.
Cutaneous Redox Senescence
Authors: Sarandy Mariáurea Matias , Gonçalves Reggiani Vilela , Valacchi Giuseppe
Published: February 2024

Our current understanding of skin cell senescence involves the role of environmental stressors (UV, O3, cigarette smoke, particulate matter, etc.), lifestyle (diet, exercise, etc.) as well as genetic factors (metabolic changes, hormonal, etc.). The common mechanism of action of these stressors is the disturbance of cellular redox balance characterized by increased free radicals and reactive oxygen species (ROS), and when these overload the intrinsic antioxidant defense system, it can lead to an oxidative stress cellular condition. The main redox mechanisms that activate cellular senescence in the skin involve (1) the oxidative damage of telomeres causing their shortening; (2) the oxidation of proteomes and DNA damage; (3) an a in lysosomal mass through the increased activity of resident enzymes such as senescence-associated β-galactosidase (SA-β-gal) as well as other proteins that are products of lysosomal activity; (4) and the increased expression of SASP, in particular pro-inflammatory cytokines transcriptionally regulated by NF-κB. However, the main targets of ROS on the skin are the proteome (oxi-proteome), followed by telomeres, nucleic acids (DNAs), lipids, proteins, and cytoplasmic organelles. As a result, cell cycle arrest pathways, lipid peroxidation, increased lysosomal content and dysfunctional mitochondria, and SASP synthesis occur. Furthermore, oxidative stress in skin cells increases the activity of p16INK4A and p53 as inhibitors of Rb and CDks, which are important for maintaining the cell cycle. p53 also promotes the inactivation of mTOR-mediated autophagic and apoptotic pathways, leading to senescence. However, these markers alone cannot establish the state of cellular senescence, and multiple analyses are encouraged for confirmation. An updated and more comprehensive approach to investigating skin senescence should include further assays of ox-inflammatory molecular pathways that can consolidate the understanding of cutaneous redox senescence.
Constraints on Acceleration in Bilingual Development: Evidence from Word Segmentation by Spanish Learning Infants
Authors: Mateu Victoria , Sundara Megha
Published: February 2024

We have previously shown that bilingual Spanish and English-learning infants can segment English iambs, two-syllable words with final stress (e.g., guiTAR), earlier than their monolingual peers. This is consistent with accelerated development in bilinguals and was attributed to bilingual infants’ increased exposure to iambs through Spanish; about 10% of English content words start with an unstressed syllable, compared to 40% in Spanish. Here, we evaluated whether increased exposure to a stress pattern alone is sufficient to account for acceleration in bilingual infants. In English, 90% of content words start with a stressed syllable (e.g., KINGdom), compared to 60% in Spanish. However, we found no evidence for accelerated segmentation of Spanish trochees by Spanish-English bilingual infants compared to their monolingual Spanish-learning peers. Based on this finding, we argue that merely increased exposure to a linguistic feature in one language does not result in accelerated development in the other. Instead, only the acquisition of infrequent patterns in one language may be accelerated due to the additive effects of the other language.
Green Innovation for Carbon Footprint Reduction in Construction Industry
Authors: López-Malest Argeime , Gabor Manuela Rozalia , Panait Mirela , Brezoi Alina , Veres Cristina
Published: February 2024

The cement-based mixture market or dry mix for the ETICS (External Thermal Insulation Composite System) is a highly competitive market and it is becoming increasingly difficult to comply with European sustainability specifications such as the development of products with a lower carbon footprint, lighter and less energy-intensive materials, lower environmental impacts, the option of recycling, etc. This market plays a highly important role in the construction sector, not only for the technical solutions and green innovation it offers but also for the aesthetic aspects. Since 2005, this market has been growing by more than 20% per year, which makes it increasingly attractive with better opportunities. However, this increase has been reduced not only by the crisis of 2007–2008 but also by the pandemic of recent years. The use of cement type CEM II, 42.5R, B-LL, together with a modified RDP ratio, has visibly improved the properties of the thermal insulation system through the adhesion of the EPS boards, the modulus of elasticity, wear resistance, flexibility, and impact resistance. Our research results as green innovation products are above the minimum values agreed by the ETICS standards; in addition, this product has in its formulation a 30% lower carbon footprint compared to any other adhesive in the construction market applied for ETICS systems; therefore, we are talking about a sustainable and clean product, suitable for rehabilitations and ecological constructions adjusted to the European policies of carbon footprint reduction.
Adhesion of Historic Tile Fragments in Outdoor Architectural Settings
Authors: Musacchi Jessica , Silva Helena M. A. R. , Cabral-Fonseca Susana , Esteves Lurdes , Delgado Rodrigues José , Rodrigues Maria Paula , Pereira Sílvia R. M.
Published: February 2024

Azulejos are part of Portugal’s most important cultural heritage. However, a large part of this heritage is at risk due to lack of or improper conservation treatments. There are, however, not many studies dedicated to the procedures and materials used in their conservation to guide the choices of conservators/restorers. Through this work, the performances of the adhesives commonly used in azulejo conservation are studied considering the extreme conditions they may experience when in an outdoor environment. Three types of adhesives were studied: acrylics, epoxies, and cellulose nitrates. The adhesives were evaluated for their workability and characterized by FTIR, DMA, and bending tests to obtain information on their adhesion effectiveness and compatibility with the azulejo ceramic substrate before and after artificial and natural ageing. When subjected to mechanical loads, the high strength and stiffness of the epoxy resins could lead to the development of new fractures in the previously undamaged ceramic matrix, making them less suitable for the adhesion of historic tile fragments. Cellulose nitrates revealed a high chemical alteration and the highest degradation rate in the mechanical properties with ageing, showing it to be the least stable in the studied conditions. The acrylic resins proved to be the most chemically stable, with less yellowing and with physical properties that revealed to be the most compatible for the adhesion of the studied azulejo fragments in outdoor environments.
Circular Economy Business Model in the Construction Industry: A Systematic Review
Authors: Jayakodi Shashini , Senaratne Sepani , Perera Srinath
Published: February 2024

The construction business environment is becoming competitive and intense, and Business Models (BMs) are receiving considerable attention as potential sources of sustainable survival and growth. Converse to the Linear Economy (LE) model that industry follows, the Circular Economy (CE) model has the potential to create a sustainable construction industry while also creating a sustainable business environment in construction organisations. Nevertheless, in traditional BMs, value is often concentrated on the financial value for the stakeholders; in the Circular Economy Business Model (CEBM), value is seen more broadly by considering a comprehensive range of value chain partners, the environment, and society. Hence, implementing the CE in the construction industry requires reforms in each value chain. Thus, the aim of this paper is to develop a conceptual model for construction organisations’ adoption of CEBM for their organisations. To accomplish this aim, the objectives of this paper are twofold: (i) to define the concept of CEBM and (ii) to map a conceptual Circular Economy Business Model Canvas (CEBMC) that is applicable in the construction organisational context. This research adopted a systematic document review, including a content analysis of selected papers. This study contributes significantly by proposing a CEBMC where construction organisations can successfully transform their businesses from linear to circular environments.
Experimental Research on Mechanism Impairment and Reinforcement of Empty Bucket Wall
Authors: Diao Rongdan , Cao Yinqiu , Li Jiangen , Sun Linzhu , Yang Fang
Published: February 2024

In this study, the raw material for the empty bucket wall consists of Dalun bricks unique to South Zhejiang. The investigation focuses on the changes in compressive properties of the empty bucket wall with masonry mortar strength grades of M 2.5, M 5.0, M 7.5, and M 10.0 after a designated period of maintenance in both dry and wet environments. Following this, the empty bucket wall undergoes reinforcement, and the compressive properties are studied. The ensuing comparisons yield pertinent conclusions. Unreinforced walls maintained with varying mortar strengths in a wet environment exhibit reduced cracking loads by 5.8 to 30% and damage loads by 5.6 to 10.8% compared to their counterparts in a dry environment. Reinforced walls, maintained with different mortar strengths in wet environments, show reduced cracking loads by 6.2% to 36% and damage loads by 2.5% to 5.7% compared to those in dry environments. The stress–strain curves of unreinforced and reinforced barrel walls of various strength classes are obtained by fitting the test stress–strain data to the stress–strain data derived from corresponding model equations. These stress–strain curves for unreinforced and reinforced walls align well with the model curves, affirming the precision of the tests.
Experimental and Numerical Investigation on Flexural Strengthening of Precast Concrete Corbel Connections with Fiber-Reinforced Plastic Sheet
Authors: Rahgozar Nima , Rahgozar Navid
Published: February 2024

This paper presents the results of experimental and numerical investigations aimed at enhancing the flexural capacity of Precast Concrete Corbel Beam–Column Connections (PC-CBCCs) using Fiber-Reinforced Plastic (FRP) sheets. The experimental study primarily focused on assessing the flexural capacity of pinned PC-CBCCs reinforced with FRP layers, comparing them to a moment-resisting connection. A series of half-scale specimens, including three PC-CBCCs with varying FRP configurations, were tested alongside one in situ concrete fixed connection. The first specimen (PC-1) utilized L-shaped and full-wrap FRPs, whereas PC-2 and PC-3 employed both U-shaped and full-wrap layers. The objective is to quantify the ultimate flexural capacity of PC-CBCCs reinforced by FRP sheets. In PC-3, the external anchorage is introduced to assess its influence on delaying the FRP layer debonding under lateral loading. The effects of the FRP layer thickness, locations, and potential debonding are examined under unidirectional static tests while applying a constant axial compressive load to the columns and subjecting the beams to lateral loads until fracture. The test results illustrate that strengthening the corbel connection with L-shaped FRP or spiral U-shaped FRP sheets without mechanical anchorage cannot result in a significant bending capacity due to debonding. However, with the incorporation of mechanical anchors, the connection manages to enhance the moment capacity to 81% of a fixed connection’s flexural capacity. Additionally, a finite element model of the PC-CBCCs and a fixed joint is developed to simulate nonlinear static analyses of the connections using ANSYS 19.2 software. The simulation model is precise in predicting the initial stiffness and ultimate capacity of the beam–column joints, as verified by the experimental results. A comprehensive comparison is conducted to determine their responses by employing various FRP configurations and properties. Moreover, design parameters such as bond length and thickness of the FRP sheets, along with appropriate mechanical anchorage, are identified as effective in preventing debonding, and delamination. However, wrapping the beam far away from the joint interface has a minimal impact on the failure mode, stress reduction, and load-bearing capacity.
Synergies and Challenges: Exploring Organizational Perspectives on Digital Transformation and Sustainable Development in the Context of Skills and Education
Authors: Tsaples Georgios , Papathanasiou Jason , Manou Dimitra
Published: February 2024

The discourse surrounding digital transformation (DT) and sustainable development (SD) is pervasive in contemporary business and organizational operations, with both processes considered indispensable for sustainability. The success or failure of these endeavors hinges significantly on factors such as the behavior and skill sets of individuals within organizations. Thus, the purpose of the paper is twofold: to investigate the perceptions of organizations on digital transformation and sustainable development with regards to skills and education, and, secondly, to use the insights from these perceptions as a starting point for the use of systems thinking as a tool that could assist in achieving these states. To achieve the objective, a research effort was conducted that included desktop research, interviews with experts, and the development of a survey that was disseminated across Europe with questions on digital transformation and sustainable development. Finally, a general causal loop diagram was designed, illustrating the processes of digital transformation and sustainable development within organizations from a top-down view. The study reveals commonalities between DT and SD, recognizing both processes as advantageous with shared deficiencies in specific skill sets. It highlights a synergistic relationship between initiating DT and fostering SD activities. Furthermore, the research underscores the temporal aspects of these processes, acknowledging delayed positive effects and immediate implementation costs that challenge decision-makers to balance long-term benefits with short-term viability. In conclusion, the exploration emphasizes the dynamic nature of DT and SD, urging continual attention to the evolving landscape and the imperative for a shared understanding within organizational contexts.
Eco-Friendly Technology Derivation and Planning for Rooftop Greenhouse Smart Farm
Authors: Lee Jieun , Lim Eunteak , Byun Nahyang , Shon Donghwa
Published: February 2024

Rooftop greenhouse-type smart farms are a promising solution to the climate and food crises because they can utilize waste heat and CO2 from buildings for plant growth and supply fresh produce to urban areas at a low price. However, legal and structural constraints make it difficult to expand existing rooftops to accommodate smart farms, and standardized glass greenhouses are often installed as is, which may not be the most efficient or eco-friendly approach. The purpose of this study is to present a plan for integrating eco-friendly technologies between buildings and smart farms. In the study, 214 eco-friendly and smart farm cases were collected, and a database was built from the perspective of the environment and eco-friendly technology for plant growth. Thirty experts from architects, professors, and greenhouse installation companies were evaluated to determine which eco-friendly technologies can be applied to smart farms. From a building integration perspective, eco-friendly technologies applicable to smart farms were derived from a plant growth perspective. Based on the derived eco-friendly elements, it can be used in planning a rooftop greenhouse-type smart farm.
Field Test and Numerical Study of Three Types of Frame Beams Subjected to a 600 kN Anchoring Force
Authors: Qin Mengchun , Dou Guosong , Yang Jianmin , Wei Shaowei
Published: February 2024

Frame beams with anchor cables constitute a crucial method for slope reinforcement projects. With the development of fabricated structures, there has been an increasing focus on precast prestressed frame beams with anchor cables. This paper presents a field test conducted in Yunnan, China and numerical simulations to analyze the structure behavior of three types of frame beams with a 600 kN anchoring force: cast-in-situ frame beams, precast prestressed frame beams, and precast prestressed frame beams with connections. The results showed that: (1) Although all three types of frame beams met the design requirements for a 600 kN anchoring force capacity, the volume of precast prestressed frame beams constituted only 57% of that of the cast-in-situ frame beams. (2) The maximum bending moment for the precast prestressed frame beams with connections was 60 kN·m less than that for the cast-in-situ frame beams. (3) The field test results for bending moments exceeded the values obtained from the numerical simulation. When using a numerical simulation to study the bending moments of the anchor frame beams, it is acceptable to apply appropriate amplifications to the numerical results. (4) Among the three types of frame beams with cables, the precast prestressed frame beams with connections exhibited the best structural performance.
Literature Review on the Structural Health Monitoring (SHM) of Sustainable Civil Infrastructure: An Analysis of Influencing Factors in the Implementation
Authors: Wang Guangbin , Ke Jiawen
Published: February 2024

Structural health monitoring (SHM) of civil infrastructure is significant for sustainable development. This review aims to identify the factors influencing sustainable civil infrastructure SHM implementation and analyze the properties, paths, and conditions under which they have an impact. The method adopted is a coding study based on Grounded Theory. First, the SHM implementation process in the literature is categorized through open coding to obtain an implementation framework that contains phase and activity levels. Second, based on this framework, a synthesis is conducted to categorize the influencing factors in dimensions of contents and properties through open coding and axial coding. Finally, selective coding is used to extract the factors that interacted across activities to propose a scheme of influencing factor relationships. The main findings of the synthesis are shown as follows: (1) sensor work scheduling and data transmission are promising endeavors to balance economic and environmental sustainability, while social sustainability is mainly in terms of safety and user experience; (2) the success of sustainable civil infrastructure SHM requires a collaborative technical and organizational effort; (3) since the influencing factors at different phases may interact with each other, the implementation process should emphasize forward-looking and holistic thinking.
Artificial Intelligence Applied to Non-Invasive Imaging Modalities in Identification of Nonmelanoma Skin Cancer: A Systematic Review
Authors: Foltz Emilie A. , Witkowski Alexander , Becker Alyssa L. , Latour Emile , Lim Jeong Youn , Hamilton Andrew , Ludzik Joanna
Published: February 2024

Background: The objective of this study is to systematically analyze the current state of the literature regarding novel artificial intelligence (AI) machine learning models utilized in non-invasive imaging for the early detection of nonmelanoma skin cancers. Furthermore, we aimed to assess their potential clinical relevance by evaluating the accuracy, sensitivity, and specificity of each algorithm and assessing for the risk of bias. Methods: Two reviewers screened the MEDLINE, Cochrane, PubMed, and Embase databases for peer-reviewed studies that focused on AI-based skin cancer classification involving nonmelanoma skin cancers and were published between 2018 and 2023. The search terms included skin neoplasms, nonmelanoma, basal-cell carcinoma, squamous-cell carcinoma, diagnostic techniques and procedures, artificial intelligence, algorithms, computer systems, dermoscopy, reflectance confocal microscopy, and optical coherence tomography. Based on the search results, only studies that directly answered the review objectives were included and the efficacy measures for each were recorded. A QUADAS-2 risk assessment for bias in included studies was then conducted. Results: A total of 44 studies were included in our review; 40 utilizing dermoscopy, 3 using reflectance confocal microscopy (RCM), and 1 for hyperspectral epidermal imaging (HEI). The average accuracy of AI algorithms applied to all imaging modalities combined was 86.80%, with the same average for dermoscopy. Only one of the three studies applying AI to RCM measured accuracy, with a result of 87%. Accuracy was not measured in regard to AI based HEI interpretation. Conclusion: AI algorithms exhibited an overall favorable performance in the diagnosis of nonmelanoma skin cancer via noninvasive imaging techniques. Ultimately, further research is needed to isolate pooled diagnostic accuracy for nonmelanoma skin cancers as many testing datasets also include melanoma and other pigmented lesions.
Cellular, Molecular and Clinical Aspects of Aortic Aneurysm—Vascular Physiology and Pathophysiology
Authors: Domagała Dominika , Data Krzysztof , Szyller Hubert , Farzaneh Maryam , Mozdziak Paul , Woźniak Sławomir , Zabel Maciej , Dzięgiel Piotr , Kempisty Bartosz
Published: February 2024

A disturbance of the structure of the aortic wall results in the formation of aortic aneurysm, which is characterized by a significant bulge on the vessel surface that may have consequences, such as distention and finally rupture. Abdominal aortic aneurysm (AAA) is a major pathological condition because it affects approximately 8% of elderly men and 1.5% of elderly women. The pathogenesis of AAA involves multiple interlocking mechanisms, including inflammation, immune cell activation, protein degradation and cellular malalignments. The expression of inflammatory factors, such as cytokines and chemokines, induce the infiltration of inflammatory cells into the wall of the aorta, including macrophages, natural killer cells (NK cells) and T and B lymphocytes. Protein degradation occurs with a high expression not only of matrix metalloproteinases (MMPs) but also of neutrophil gelatinase-associated lipocalin (NGAL), interferon gamma (IFN-γ) and chymases. The loss of extracellular matrix (ECM) due to cell apoptosis and phenotype switching reduces tissue density and may contribute to AAA. It is important to consider the key mechanisms of initiating and promoting AAA to achieve better preventative and therapeutic outcomes.
Integrating “Super Skills for Exams” Programme in the School Curriculum to Support Adolescents Preparing for Their National Examinations in Turkey
Authors: Uzun Bilge , Orman Asli , Essau Cecilia A.
Published: February 2024

Examination stress is the most common stressor reported by adolescents across the globe. Exam stress involves mental distress related to anticipated academic challenges or fear of failure in the examinations, test anxiety, or fear of being unable to meet certain expectations of themselves or others. The aim of this study was to determine the effectiveness of a transdiagnostic resilience program (Super Skills for Exams; SSE), when integrated in the school curriculum and delivered by the school counsellors, in reducing exam stress among adolescents who are preparing for their national examinations. SSE is based on the principles of Cognitive Behaviour Therapy (CBT), behavioural activation, and social skills training, and includes sessions in promoting healthy lifestyles. Participants were 7129 (3661 female and 3468 male) adolescents in grades 7 and 8, from all the 245 secondary schools from Ugur College in seven regions and 31 cities across Turkey. All the participants completed a set of questionnaires to measure self-efficacy for learning and test anxiety, academic stress, emotion regulation, and lifestyles. Results revealed significant reduction in academic stress (i.e., test anxiety, work pressure, self-expectation, and despondency) and maladaptive emotion regulation strategies, and significant increase in self-efficacy and adaptive regulation strategies following the intervention. Adolescents who participated in SSE reported an increase in the consumption of healthy food. This study provides preliminary empirical support for the integration of SSE within the school curriculum for helping adolescents cope with exam stress as they prepare for their national exams.
Interference Management Based on Meta-Heuristic Algorithms in 5G Device-to-Device Communications
Authors: Benbraika Mohamed Kamel , Kraa Okba , Himeur Yassine , Telli Khaled , Atalla Shadi , Mansoor Wathiq
Published: February 2024

Device-to-Device (D2D) communication is an emerging technology that is vital for the future of cellular networks, including 5G and beyond. Its potential lies in enhancing system throughput, offloading the network core, and improving spectral efficiency. Therefore, optimizing resource and power allocation to reduce co-channel interference is crucial for harnessing these benefits. In this paper, we conduct a comparative study of meta-heuristic algorithms, employing Genetic Algorithms (GAs), Particle Swarm Optimization (PSO), Bee Life Algorithm (BLA), and a novel combination of matching techniques with BLA for joint channel and power allocation optimization. The simulation results highlight the effectiveness of bio-inspired algorithms in addressing these challenges. Moreover, the proposed amalgamation of the matching algorithm with BLA outperforms other meta-heuristic algorithms, namely, PSO, BLA, and GA, in terms of throughput, convergence speed, and achieving practical solutions.
Pathological Findings in Hanging: Is the Traditional Knowledge Correct?
Authors: Crudele Graziano Domenico Luigi , Amadasi Alberto , Franceschetti Lorenzo , Cattaneo Cristina
Published: February 2024

Background: In forensic pathology, asphyxia presents a problem as frequently as it is thorny and challenging. Some knowledge in forensic pathology is still considered to be traditionally acquired and is not critically assessed with modern statistical or technical tools. In this study, we seek to examine the injuries that are considered to be typical of cases of hanging (neck lesions, haemorrhages, and pleural and epicardial petechiae). Methods: We evaluated whether there was, indeed, a statistically significant association between these injuries and deaths from hanging as compared to non-hanging deaths. We collected 399 cases (32 deaths by hanging and 367 cases of non-hangings), built contingency tables and performed chi-square tests for each variable (lesion) examined; we also analysed this association in various subgroups of the sample (according to sex, age and weight ranges). Results: Our results did not deviate from the expected outcome based on traditional knowledge, although they do provide a more detailed demonstration and clarification of traditional knowledge regarding this topic. Conclusions: These findings provide valuable insights for future discussion, examination and deepening of knowledge that is traditionally accepted but often undersupported in the literature.
Advanced Characterization of a Hybrid Shielding Solution for Reducing Electromagnetic Interferences at Board Level
Authors: Victoria Jorge , Suarez Adrian , Martinez Pedro A. , Amaro Andrea , Alcarria Antonio , Torres Jose , Herraiz Roberto , Solera Victor , Martinez Víctor , Garcia-Olcina Raimundo
Published: February 2024

The development of new advanced functionalities, miniaturization, and the aim of obtaining optimized performance in electronic devices significantly impacts their electromagnetic compatibility (EMC). As electronic components become more densely packed on a printed circuit board (PCB), unintended coupling between components can cause electromagnetic interference (EMI). These requirements result in design restrictions that make using a board level shield (BLS) essential in reducing intra-system EMI in PCB designs. This contribution focuses on studying and characterizing a BLS solution based on combining a noise suppression sheet (NSS) with an aluminum layer to reduce intra-system EMI coupling. This hybrid solution has the advantage of providing a shielding option that does not require any electronic redesign. It does not need a footprint or a ground connection as it can be affixed over the EMI source. The solution is expected to provide higher attenuation levels than using only an NSS by combining the absorbing properties of the magnetic material and the loss mechanism of the metal. In order to verify the effectiveness of the hybrid BLS proposed solution, the magnetic near-field emissions of an EMI source are analyzed in this study. The experimental measurements and simulated results demonstrate a significant increase (51.6 dB at 1 GHz) in the shielding effectiveness (SE) provided by the proposed solution compared to a conventional NSS.
Alternative Performance Indices-Based Control Technique for a Unity Power Factor Three-Phase Rectifier
Authors: Zhang Shaoru , Liu Xiaoyan , Jia Yikun , Wang Pingjun , Wang Jingmin , Zhang Jielu
Published: February 2024

The implementation of a unity power factor (UPF) three-phase rectifier has the potential to enhance the power factor (PF). However, the PF and total harmonic distortion (THD) experience degradation in low-output regions due to the utilization of a “critical input inductor” under rated load conditions. In this study, an analysis of the operation principle of a UPF three-phase rectifier is conducted and a reference compensation current technique based on alternative performance indices is proposed. The optimal control algorithm is utilized to calculate the single harmonic phase delay of each phase and determine the compensator gain, taking into account factors such as the single harmonic distortion limit, THD limit, PF, and active power consumption. The output of the current compensator serves as the desired current source, which in turn drives the bidirectional switches. The simulation and experimental results demonstrate that the proposed control technique can significantly mitigate power supply current distortion, and the input power factor has been effectively improved within a wider load range.
Cultivating Ensemble Diversity through Targeted Injection of Synthetic Data: Path Loss Prediction Examples
Authors: Sotiroudis Sotirios P.
Published: February 2024

Machine Learning (ML)-based models are steadily gaining popularity. Their performance is determined from the amount and the quality of data used at their inputs, as well as from the competence and proper tuning of the ML algorithm used. However, collecting high-quality real data is time-consuming and expensive. Synthetic Data Generation (SDG) is therefore employed in order to augment the limited real data. Moreover, Ensemble Learning (EL) provides the framework to optimally combine a set of standalone ML algorithms (base learners), capitalizing on their individual strengths. Base learner diversity is essential to build a strong ensemble. The proposed method of Targeted Injection of Synthetic Data (TIoSD) combines the EL and SDG concepts in order to further diversify the base learners’ predictions, thus giving rise to an even stronger ensemble model. We have applied TIoSD in two different Path Loss (PL) datasets, using two well-established SDG methods (namely SMOGN and CTGAN). While the conventional ensemble model reached a Minimum Absolute Error (MAE) value of 3.25 dB, the TIoSD-triggered ensemble provided a MAE value of 3.16 dB. It is therefore concluded that targeted synthetic data injection, due to its diversity-triggering characteristics, enhances the ensemble’s performance. Moreover, the ratio between synthetic and real data has been investigated. The results showed that a proportion of 0.1 is optimal.
Virtual/Augmented Reality Applications in Education & Life Long Learning
Authors: Paliokas Ioannis , Theodorou Paraskevi
Published: February 2024

Recent advancements in educational technology highlight the significance of disruptive technologies in enhancing Learning Experiences (LX) in a more targeted, personalized, and engaging context [...]
Sensitivity Assessment of Building Energy Performance Simulations Using MARS Meta-Modeling in Combination with Sobol’ Method
Authors: Nouri Amin , van Treeck Christoph , Frisch Jérôme
Published: February 2024

Large discrepancies can occur between building energy performance simulation (BEPS) outputs and reference data. Uncertainty and sensitivity analyses are performed to discover the significant contributions of each input parameter to these discrepancies. Variance-based sensitivity analyses typically require many stochastic simulations, which is computationally demanding (especially in the case of the large number of input parameters involved in the analysis). To overcome these impediments, this study proposes a reliable meta-model-based sensitivity analysis, including validation, Morris’ method, multivariate adaptive regression splines (MARS) meta-modeling, and Sobol’ method, to identify the most influential input parameters on BEPS prediction (annual energy consumption) at the early building design process. A hypothetical building is used to analyze the proposed methodology. Six statistical metrics are applied to verify and quantify the accuracy of the model. It is concluded that the cooling set-point temperature and g-value of the window are the most influential input parameters for the analyzed case study.
A Multi-Step Ensemble Approach for Energy Community Day-Ahead Net Load Point and Probabilistic Forecasting
Authors: Ruano Maria da Graça , Ruano Antonio
Published: February 2024

The incorporation of renewable energy systems in the world energy system has been steadily increasing during the last few years. In terms of the building sector, the usual consumers are becoming increasingly prosumers, and the trend is that communities of energy, whose households share produced electricity, will increase in number in the future. Another observed tendency is that the aggregator (the entity that manages the community) trades the net community energy in public energy markets. To accomplish economically good transactions, accurate and reliable forecasts of the day-ahead net energy community must be available. These can be obtained using an ensemble of multi-step shallow artificial neural networks, with prediction intervals obtained by the covariance algorithm. Using real data obtained from a small energy community of four houses located in the southern region of Portugal, one can verify that the deterministic and probabilistic performance of the proposed approach is at least similar, typically better than using complex, deep models.
COVID-19 Impacts on Mexican Power Sector
Authors: Salgado-Conrado Lizbeth , Álvarez-Macías Carlos , Pérez-García Laura-Andrea , Loera-Palomo Rodrigo
Published: February 2024

The study investigated the changes that occurred in the Mexican power sector before, during, and after the COVID-19 pandemic and its repercussions on the electricity sector and energy sustainability goals. The study was based on the variability of the installed capacity, consumption, generation, and demand of the National Electric System (SEN), covering the period from 2017 to 2021. The data were collected from the Development of the National Electric System (PRODESEN), the Ministry of Energy, the National Energy Balance, and the government’s official website. The results indicated that installed capacity and generation increased by 22.83% and 27.86%, respectively, despite the pandemic. This growth was attributed to clean energy, mainly from photovoltaic solar and wind sources. Another finding was that the gross domestic product (GDP), consumption, and demand were seriously affected by COVID-19. They had a fall of 8.2%, 2.2%, and 4.4%, respectively, which translates into a significant economic lag and a slowdown in energy self-sufficiency and the Mexican Energy Transition (TEM). Moreover, the objective of generating 35% and 40% of electrical energy through clean energy will be achieved by 2031 and 2035, instead of 2021 and 2035, respectively.
Influence of the Shrinkage of the Inner Layer of Steel Tubes on Permissible Thermal Load
Authors: Zieliński Mateusz , Koniorczyk Piotr , Surma Zbigniew
Published: February 2024

This paper presents the results of numerical simulations of heat transfer in a tube with a protective chromium layer on the inner surface made of steel, with different shrinkage temperatures. Shrinkage in the steel is an unfavorable phenomenon because it causes cracks in the chrome coating. The cracks contribute to the peeling of the protective material on the inner surface of the tube. Wear and damage to the chrome layer significantly shortens the tube’s service life. The influence of the type of steel with medium carbon content on heat transfer for a sequence of ten, thirty, and sixty heat impulses was examined. Simulations were carried out for two selected steels with clearly different shrinkage temperatures, i.e., 30HN2MFA and X37CrMoV5-1 (1.2343). In 30HN2MFA steel, the shrinkage effect occurred at a temperature of approx. 750 °C, while in X37CrMoV5-1 steel it occurred at a temperature of approx. 870 °C. In the computational model, 30 cross-sections of the three-meter-long tube were analyzed. A time-dependent heat transfer coefficient was calculated in each zone. Heat transfer simulations were carried out using COMSOL version 6.1 software. This paper shows that for X37CrMoV5-1 steel, the shrinkage temperature on the inner surface of the tube was reached after approx. 60 heat impulses, while for 30HN2MFA steel, it was reached after approx. 30. The greatest differences in the number of impulses occurred for a pipe with a 200 µm thick chrome layer.