bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Fault-Tolerant Operation Capabilities of an Isolated Bidirectional Current-Source DC–DC Converter
Authors: Blinov Andrei , Kosenko Roman , Chub Andrii , Ivakhno Volodymyr
Published: August 2019

Reliable and predictable operation of power electronics is of increasing importance due to continuously growing penetration of such systems in industrial applications. This article focuses on the fault-tolerant operation of the bidirectional secondary-modulated current-source DC–DC converter. The study analyzes possible topology reconfigurations in case an open- or short-circuit condition occurs in one of the semiconductor devices. In addition, multi-mode operation based on topology-morphing is evaluated to extend the operating range of the case study topology. The influence of post-failure modes on the functionality and performance is analyzed with a 300 W converter prototype. It is demonstrated that failure of one transistor in the current-source side can be mitigated without dramatic loss in the efficiency at maximum power, while preserving bidirectional operation capability.
Condition Monitor System for Rotation Machine by CNN with Recurrence Plot
Authors: Hsueh Yumin , Ittangihala Veeresha Ramesha , Wu Wei-Bin , Chang Hong-Chan , Kuo Cheng-Chien
Published: August 2019

Induction motors face various stresses under operating conditions leading to some failure modes. Hence, health monitoring for motors becomes essential. In this paper, we introduce an effective framework for fault diagnosis of 3-phase induction motors. The proposed framework mainly consists of two parts. The first part explains the preprocessing method, in which the time-series data signals are converted into two-dimensional (2D) images. The preprocessing method generates recurrence plots (RP), which represent the transformation of time-series data such as 3-phase current signals into 2D texture images. The second part of the paper explains how the proposed convolutional neural network (CNN) extracts the robust features to diagnose the induction motor’s fault conditions by classifying the images. The generated RP images are considered as input for the proposed CNN in the texture image recognition task. The proposed framework is tested on the dataset collected from different 3-phase induction motors working with different failure modes. The experimental results of the proposed framework show its competitive performance over traditional methodologies and other machine learning methods.
The Use of Acidic Hydrolysates after Furfural Production from Sugar Waste Biomass as a Fermentation Medium in the Biotechnological Production of Hydrogen
Authors: Cieciura-Włoch Weronika , Binczarski Michał , Tomaszewska Jolanta , Borowski Sebastian , Domański Jarosław , Dziugan Piotr , Witońska Izabela
Published: August 2019

This study investigates a simultaneous processing of sugar beet pulp (SBP) for furfural, hydrogen and methane production using various pretreatment methods. In the experiments, sugar beet pulp was first subjected to thermal and thermochemical pretreatment at 140 °C. Then hydrolysates from these operations were investigated for their potential for methane and hydrogen production in batch tests. The experiments showed that thermal pretreatment of SBP resulted in the highest biogas and methane yields of 945 dm3/kg volatile solids (VS) and 374 dm3 CH4/kg VS, respectively, and a moderate hydrogen production of 113 dm3 H2/kg VS, which corresponded to a calculated energy production of 142 kWh/t; however, only low amount of furfural was obtained (1.63 g/L). Conversely, the highest furfural yield of 12 g/L was achieved via thermochemical pretreatment of SBP; however, biogas production from hydrolysate was much lower (215 dm3/kg VS) and contained only 67 dm3/kg VS of hydrogen. Meanwhile, in the experiment with lower amounts of sulfuric acid (2%) used for pretreatment, a moderate furfural production of 4 g/L was achieved with as high as 220 dm3/kg VS of hydrogen and the corresponding energy yield of 75 kWh/t.
Image Analysis to Monitor Experimental Trampling and Vegetation Recovery in Icelandic Plant Communities
Authors: Runnström Micael C. , Ólafsdóttir Rannveig , Blanke Jan , Berlin Bastian
Published: August 2019

With growing tourism in natural areas, monitoring recreational impacts is becoming increasingly important. This paper aims to evaluate how different trampling intensities affect some common Icelandic plant communities by using digital photographs to analyze and quantify vegetation in experimental plots and to monitor vegetation recovery rates over a consecutive three-year period. Additionally, it seeks to evaluate the use of image analysis for monitoring recreational impact in natural areas. Experimental trampling was conducted in two different sites representing the lowlands and the highlands in 2014, and the experimental plots were revisited in 2015, 2016, and 2017. The results show that moss has the highest sensitivity to trampling, and furthermore has a slow recovery rate. Moss-heaths in the highlands also show higher sensitivity and slower recovery rates than moss-heaths in the lowlands, and grasslands show the highest resistance to trampling. Both methods tested, i.e., Green Chromatic Coordinate (GCC) and Maximum Likelihood Classification (MLC), showed significant correlation with the trampling impact. Using image analysis to quantify the status and define limits of use will likely be a valuable and vital element in managing recreational areas. Unmanned aerial vehicles (UAVs) will add a robust way to collect photographic data that can be processed into vegetation parameters to monitor recreational impacts in natural areas.
Interaction Mechanism of Flavonoids and α-Glucosidase: Experimental and Molecular Modelling Studies
Authors: He Chengyun , Liu Xiaoling , Jiang Zhaojing , Geng Sheng , Ma Hanjun , Liu Benguo
Published: August 2019

Flavonoids are known to play a role in hypoglycemia by inhibiting α-glucosidase. However, their interaction mechanism with α-glucosidase still needs to be elaborated. In this study, the α-glucosidase inhibitory activities of 15 flavonoids were investigated. Their molecular volume had a negative effect on inhibitory activity, while the number of phenolic hydroxyl groups on the B ring was positively correlated with inhibitory activity. To explain the significant differences in activity, the interaction behaviors of myricetin and dihydromyricetin, which have similar structures, were compared by spectrofluorimetry, molecular docking, and the independent gradient model (IGM). In the fluorescence analysis, myricetin exhibited a higher binding capacity. Based on molecular docking and IGM analysis, their non-covalent interactions with α-glucosidase could be visualized and quantified. It was found that they had different binding modes with the enzymes and that myricetin possessed stronger hydrogen bonding and van der Waals force interactions, which explained the thermodynamic results.
Foreign Stories and National Narratives: Yiddish and Fictionality in Jurek Becker’s Jakob the Liar and Edgar Hilsenrath’s The Nazi and the Barber
Authors: Woelk Emma
Published: August 2019

This article uses two examples of postwar German Jewish literature to explore the way in which these literary reflections on fictionality can also serve to subvert and complicate the national narratives that were developed in East and West Germany. The novels explored here, Jurek Becker’s Jakob the Liar (1969) and Edgar Hilsenrath’s The Nazi and the Barber (1977), directly thematize storytelling and specifically, storytelling in the context of the Holocaust and its aftermath. Both also share an interest in the intersections between German and Yiddish narrative traditions and reflect on the ways in which the latter was coopted by the former in the decades following the Second World War. Ultimately, this article argues that these two novels of lying create spaces in which the foundational myths of both German states are called into question.
Levels of Urinary Biomarkers of Oxidatively Generated Damage to DNA and RNA in Different Groups of Workers Compared to General Population
Authors: Tranfo Giovanna , Paci Enrico , Carrieri Mariella , Marchetti Enrico , Sisto Renata , Gherardi Monica , Costabile Francesca , Bauleo Lisa , Ancona Carla , Pigini Daniela
Published: August 2019

(1) Background: The products of guanine oxidation in DNA and RNA excreted in urine are 8-oxo-7,8-dihydroguanine (8-oxoGua), 8-oxo-7,8-dihydroguanosine (8-oxoGuo), and 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodGuo). Despite intra and inter-individual variability, it is possible to identify situations that significantly increase the levels of these compounds when comparing urinary concentrations of some workers to those of the general population. (2) Methods: urines from gasoline pump attendants (58 from Saudi Arabia and 102 from Italy), 24 workers of a fiberglass reinforced plastics plant, 17 painters and 6 divers were analyzed by HPLC/MS-MS. To test the individual variability, two subjects provided daily samples for one month, and 132 urine samples from the general population were analyzed. (3) Results: We summarized the results for each biomarker, and found the following were statistically higher than in the general population: 8-oxoGua in fiberglass and Italian gasoline workers; 8-oxodGuo in fiberglass and both Saudi Arabian and Italian gasoline workers; 8-oxoGuo in fiberglass workers, both Saudi Arabian and Italian gasoline workers, and painters after the working shift. (4) Conclusions: these results confirm that both 8-oxodGuo and 8-oxoGuo are valuable biomarkers for occupational exposures to dangerous chemicals and seem to suggest that 8-oxoGuo, related to RNA oxidation, is a suitable biomarker to evaluate short term, reversible effects of occupational exposures even within the health-based limit values.
Public Perception towards Waste-to-Energy as a Waste Management Strategy: A Case from Shandong, China
Authors: Yuan Xueliang , Fan Xiaohan , Liang Jiaxin , Liu Mengyue , Teng Yuqiang , Ma Qiao , Wang Qingsong , Mu Ruimin , Zuo Jian
Published: August 2019

Municipal solid waste (MSW) is posing great challenge for most countries in the world, which can cause severe negative impacts to the environment and human health. Waste-to-energy has great potential in China because of its technological maturity and policy support at the national level. However, there are significant conflicts between the huge market demand and strong public opposition. It is imperative to examine the public perception of waste-to-energy, especially for developing countries where a large number of projects are under construction or have been approved. The public perception of waste-to-energy was carried out by a questionnaire survey in this research. A total of 650 questionnaires were distributed and 629 questionnaires were returned, with a response rate of 96.8%. The results show that the public showed general concern in regard to environmental issues. Respondents had an overall positive attitude towards waste-to-energy, but it varied according to the demographic details of residents, such as age, education, and income. Recognition level of the benefits was higher than the concern of associated risks. Multiple linear regression shows that awareness of environmental issues had no impact on public attitude towards waste-to-energy, while public awareness and perceived benefits had notable positive impacts. Perceived risks had a positive correlation with public attitude. In order to promote the development of MSW incinerators, the government should make more publicity efforts. Rural residents, people over 50 years old, and people with low education and low income are the major groups which should be focused on to enhance the public perception. The findings provide a theoretical and practical reference for enhancing the social acceptance of waste-to-energy development.
Migration, Work, and Health: Lessons Learned from a Clinical Case Series in a Northern Italy Public Hospital
Authors: Arici Cecilia , Tamhid Tishad , Porru Stefano
Published: August 2019

Background: Migrant workers (MWs) generally perform dangerous jobs and have reduced access to occupational health (OH) care, therefore being prone to developing occupational diseases (OD). The aim of the work is to describe a case series of MWs and report on related outcomes for OH professionals. Methods: A case series of 724 MWs, sent from January 2001 to June 2013 to a public OH unit for OD or fitness-for-work (FFW) evaluation, was entered in a dedicated database and elaborated for descriptive statistics with Microsoft Excel. Results: MWs were mostly (75%) men, with a mean age of 40. They came mainly from Morocco, Senegal, Albania, Romania, and Pakistan. Main sectors of employment were manufacturing, metal industry, services, construction. OD were found in 210 cases, main diagnoses being: Lumbar disc and upper limb musculoskeletal disorders (51%), contact dermatitis (15%), allergic asthma (8%), noise-induced hearing loss (7%), tumors (3%), psychiatric disorders (2%). Moreover, 136 FFW judgements were formulated, with some limitations/restrictions expressed. Finally, a relevant prevalence of some chronic non-occupational diseases was found. Conclusions: MWs in Italy may suffer from OH inequalities. Qualified public OH professionals and occupational physicians in workplaces should have a proactive role to concretely meet MWs’ health needs.
Predictors of Number of Healthcare Professionals Consulted by Individuals with Mental Disorders or High Psychological Distress
Authors: Simo Béatrice , Caron Jean , Bamvita Jean-Marie , Grenier Guy , Fleury Marie-Josée
Published: August 2019

This study assesses the contribution of predisposing, enabling, and needs factors and related variables that predicted the number of healthcare professionals consulted for mental health reasons among 746 individuals with mental disorders and high psychological distress. The data were drawn from the third (T3) and fourth data collection periods (T4) of a longitudinal study conducted in a Quebec/Canada epidemiological catchment area. Hierarchical linear regression was performed on the number of types of healthcare professionals consulted in the 12 months prior to T4. Predictors were identified at T3, classified as predisposing, enabling, and needs factors (i.e., clinical and related variables) according to the Andersen Behavioral Model. Three needs factors were associated with the number of types of healthcare professionals consulted: Post-traumatic stress disorder, stressful events, and marginally suicide ideation. Three enabling factors: Having a family physician, previous use of mental health services, and employment status were also related to the dependent variable. Poor self-perception of mental health status was the only predisposing factor retained. While needs factors were the main predictors of the number of types of healthcare professionals consulted, enabling factors may reduce the influence of needs factors, by the deployment of various strategies that facilitate continuous and appropriate care.
Skin Conductance Responses Indicate Children are Physiologically Aroused by Their Favourite Branded Food and Drink Products
Authors: Smith Rachel , Kelly Bridget , Yeatman Heather , Johnstone Stuart , Baur Louise , King Lesley , Boyland Emma , Chapman Kathy , Hughes Clare , Bauman Adrian
Published: August 2019

Children’s favourite food and beverage brands use various tactics to foster positive associations and loyalty. This brand-consumer dynamic is frequently influenced by the use of implicit techniques and emotional appeals. Few studies have used physiological methods to examine the connections that brands build with children and the influence this has on their automatic responses. These techniques are potentially less prone to bias than behavioural or cognitive methods. This is the first study to explore the implicit response that children have to images of their favourite food and beverage brands using skin conductance responses as a marker of arousal. Australian children aged 8–11 years (n = 48) were recruited. Images of the participants’ favourite branded food and beverage products, alongside images of the same products unpackaged, their family and friends, and neutral objects were presented in a randomised order with a standard timed interval between images. Children were significantly more aroused by branded images of their favourite food and beverage products than by their unpackaged counterparts (p < 0.042, d = 0.4). The physiological response to the branded products was similar to the response to the children’s family and friends (p = 0.900, d = −0.02). These findings suggest that children may have an implicit connection to their favourite branded products.
The Use of HPLC-PDA in Determining Nicotine and Nicotine-Related Alkaloids from E-Liquids: A Comparison of Five E-Liquid Brands Purchased Locally
Authors: Palazzolo Dominic , Nelson John , Hudson Zuri
Published: August 2019

E-liquid manufacturers are under scrutiny concerning the purity and concentration accuracy of nicotine and the minor nicotine-related alkaloids (NRAs) packaged in their products. In this communication we report concentrations of nicotine and five NRAs (nornicotine, cotinine, anabasine, anatabine, myosmine) from locally purchased E-liquids. Methods: Five brands of E-liquids (three bottles each) were purchased locally. Additionally, three bottles of reference E-liquid were prepared. Concentrations of nicotine and NRAs from each bottle were measured by HPLC. Concentrations of these alkaloids were also determined from electronic cigarette-generated aerosol and traditional cigarette smoke. Results: Nicotine concentrations in E-liquid brands 1, 2, 3, 4, 5 and in the reference E-liquid were 17.8 ± 4.1, 23.2 ± 0.7, 24.0 ± 0.9, 24.9 ± 0.2, 19.7 ± 0.3 and 20.4 ± 0.1 mg/mL, respectively. Concentrations normalized to 100% of product label were 74%, 97%, 100%, 104%, 109% and 102%, respectively. E-liquid brand 1 showed significance (p < 0.001) between bottles, while the reference showed the least variability. Similar results were obtained for the NRAs. Results also indicated the NRAs in aerosol of the reference E-liquid are lower than in cigarette smoke. Conclusions: The amounts of NRAs present in E-liquids and E-liquid aerosol are less compared to cigarettes, however, inconsistencies and variation in nicotine concentrations supports the need for regulatory oversight.
Distribution and Chemical Analysis of Pharmaceuticals and Personal Care Products (PPCPs) in the Environmental Systems: A Review
Authors: Ohoro C.R. , Adeniji A.O. , Okoh A.I. , Okoh O.O.
Published: August 2019

PPCPs are found almost everywhere in the environment especially at an alarming rate and at very low concentration in the aquatic systems. Many methods—including pressurized hot water extraction (PHWE), pressurized liquid extraction (PLE), ultrasound-assisted extraction (UAE), and micro-assisted extraction (MAE)—have been employed for their extraction from both surface waters and biota. Solid-phase extraction (SPE) proved to be the best extraction method for these polar, non-volatile, and thermally unstable compounds in water. However, ultrasonic extraction works better for their isolation from sediment because it is cheap and consumes less solvent, even though SPE is preferred as a clean-up method for sediment samples. PPCPs are in groups of—acidic (e.g., diclofenac, ibuprofen, naproxen), neutral (e.g., caffeine, carbamazepine, fluoxetine), and basic pharmaceuticals, as well as antibiotics and estrogens amongst others. PPCPs which are present in trace levels (ng/L) are more often determined by liquid chromatography-mass spectrometry (LC-MS), gas chromatography-mass spectrometry (GC-MS), and high-performance liquid chromatography-ultraviolent (HPLC-UV). Of these, LC-MS and LC-MS-MS are mostly employed for the analysis of this class of compounds, though not without a draw-back of matrix effect. GC-MS and GC-MS-MS are considered as alternative cost-effective methods that can also give better results after derivatization.
Expressing History through a Geo-Spatial Ontology
Authors: Southall Humphrey , Aucott Paula
Published: August 2019

Conventional Geographical Information Systems (GIS) software struggles to represent uncertain and contested historical knowledge. An ontology, meaning a semantic structure defining named entities, and explicit and typed relationships, can be constructed in the absence of locational data, and spatial objects can be attached to this structure if and when they become available. We describe the overall architecture of the Great Britain Historical GIS, and the PastPlace Administrative Unit Ontology that forms its core. Then, we show how particular historical geographies can be represented within this architecture through two case studies, both emphasizing entity definition and especially the application of a multi-level typology, in which each “unit” has an unchanging “type” but also a time-variant “status”. The first includes the linked systems of Poor Law unions and registration districts in 19th century England and Wales, in which most but not all unions and districts were coterminous. The second case study includes the international system of nation-states, in which most units do not appear from nothing, but rather gain or lose independence. We show that a relatively simple data model is able to represent much historical complexity.
Left Ventricular Hypertrophy: Roles of Mitochondria CYP1B1 and Melatonergic Pathways in Co-Ordinating Wider Pathophysiology
Authors: Anderson George , Mazzoccoli Gianluigi
Published: August 2019

Left ventricular hypertrophy (LVH) can be adaptive, as arising from exercise, or pathological, most commonly when driven by hypertension. The pathophysiology of LVH is consistently associated with an increase in cytochrome P450 (CYP)1B1 and mitogen-activated protein kinases (MAPKs) and a decrease in sirtuins and mitochondria functioning. Treatment is usually targeted to hypertension management, although it is widely accepted that treatment outcomes could be improved with cardiomyocyte hypertrophy targeted interventions. The current article reviews the wide, but disparate, bodies of data pertaining to LVH pathoetiology and pathophysiology, proposing a significant role for variations in the N-acetylserotonin (NAS)/melatonin ratio within mitochondria in driving the biological underpinnings of LVH. Heightened levels of mitochondria CYP1B1 drive the ‘backward’ conversion of melatonin to NAS, resulting in a loss of the co-operative interactions of melatonin and sirtuin-3 within mitochondria. NAS activates the brain-derived neurotrophic factor receptor, TrkB, leading to raised trophic signalling via cyclic adenosine 3′,5′-monophosphate (cAMP)-response element binding protein (CREB) and the MAPKs, which are significantly increased in LVH. The gut microbiome may be intimately linked to how stress and depression associate with LVH and hypertension, with gut microbiome derived butyrate, and other histone deacetylase inhibitors, significant modulators of the melatonergic pathways and LVH more generally. This provides a model of LVH that has significant treatment and research implications.
A Low-Cost Robotic Camera System for Accurate Collection of Structural Response
Authors: Kromanis Rolands , Forbes Christopher
Published: August 2019

Vision-based technologies are becoming ubiquitous when considering sensing systems for measuring the response of structures. Availability of proprietary camera systems has opened up the scope for many bridge monitoring projects. Even though structural response can be measured at high accuracies when analyzing target motions, the main limitations to achieving even better results are camera costs and image resolution. Conventional camera systems capture either the entire structure or large/small part of it. This study introduces a low-cost robotic camera system (RCS) for accurate measurement collection of structural response. The RCS automatically captures images of parts of a structure under loading, therefore, (i) giving a higher pixel density than conventional cameras capturing the entire structure, thus allowing for greater measurement accuracy, and (ii) capturing multiple parts of the structure. The proposed camera system consists of a modified action camera with a zoom lens, a robotic mechanism for camera rotation, and open-source software which enables wireless communication. A data processing strategy, together with image processing techniques, is introduced and explained. A laboratory beam subjected to static loading serves to evaluate the performance of the RCS. The response of the beam is also monitored with contact sensors and calculated from images captured with a smartphone. The RCS provides accurate response measurements. Such camera systems could be employed for long-term bridge monitoring, in which strains are collected at strategic locations, and response time-histories are formed for further analysis.
Chronometric Quantitation of Analytes in Paper-Based Microfluidic Devices (MicroPADs) via Enzymatic Degradation of a Metastable Biomatrix
Authors: Jangid Aditya R. , Strong E. Brandon , Escamilla Emiliano , Lore Brittany A. , Tod Nicholas J. , Thiel Robert , Martinez Andres W. , Martinez Nathaniel W.
Published: August 2019

The following article summarizes United States Patent Application No. US20180052155A1, titled ‘Assay Devices and Methods’ (filed 16 August 2016, published 22 February 2018). While lateral flow assays (LFAs) have revolutionized point-of-care diagnostics by enabling accurate, inexpensive, and rapid detection of biomarkers, they typically do not provide quantitative results. Hence, there is a significant need for quantitative assays at the point of care. This patent summary describes a novel method of chronometric biomarker quantitation via enzymatic degradation of a metastable gelatin-based biomatrix, principally suited for use in paper-based microfluidic devices (microPADs). This new quantitation mechanism was designed to meet the ASSURED criteria for point-of-care diagnostic devices laid forth by the World Health Organization and may ultimately provide increased access to healthcare, at a significantly reduced cost, around the world.
Sedentary Time, Physical Activity, and Sleep Duration: Associations with Body Composition in Fibromyalgia. The Al-Andalus Project
Authors: Gavilán-Carrera Blanca , Acosta-Manzano Pedro , Soriano-Maldonado Alberto , Borges-Cosic Milkana , Aparicio Virginia A. , Delgado-Fernández Manuel , Segura-Jiménez Víctor
Published: August 2019

To explore the individual–independent relationships of sedentary time (ST) and physical activity (PA) (light and moderate-to-vigorous intensity (MVPA)), with sleep duration and body composition (waist circumference, body mass index (BMI), body fat percentage, and muscle mass index) in women with fibromyalgia, and to determine whether these associations are independent of physical fitness. This cross-sectional study involved 385 women with fibromyalgia. ST and PA were assessed by triaxial accelerometry, sleep duration was self-reported. Waist circumference was measured using an anthropometric tape, and body weight, body fat percentage, and muscle mass were estimated using a bio-impedance analyzer. In individual regression models, ST and sleep were directly associated with waist circumference, BMI, and body fat percentage (β between 0.10 and 0.25; all p < 0.05). Light PA and MVPA were inversely associated with waist circumference, BMI, and body fat percentage (β between −0.23 and −0.12; all p < 0.05). In multiple linear regression models, ST (β between 0.17 and 0.23), light PA (β between −0.16 and −0.21), and sleep duration (β between 0.11 and 0.14) were independently associated with waist circumference, BMI, and body fat percentage (all p < 0.05). MVPA was associated with waist circumference independent of light physical activity (LPA) and sleep duration (β = −0.11; p < 0.05). Except for MVPA, these associations were independent of physical fitness. These results suggest that longer ST and sleep duration, and lower PA levels (especially light intensity PA), are independently associated with greater adiposity, but not muscle mass, in women with fibromyalgia. These associations are, overall, independent of physical fitness.
Antibody Therapies for Acute Myeloid Leukemia: Unconjugated, Toxin-Conjugated, Radio-Conjugated and Multivalent Formats
Authors: Williams Brent A. , Law Arjun , Hunyadkurti Judit , Desilets Stephanie , Leyton Jeffrey V. , Keating Armand
Published: August 2019

In recent decades, therapy for acute myeloid leukemia (AML) has remained relatively unchanged, with chemotherapy regimens primarily consisting of an induction regimen based on a daunorubicin and cytarabine backbone, followed by consolidation chemotherapy. Patients who are relapsed or refractory can be treated with allogeneic hematopoietic stem-cell transplantation with modest benefits to event-free and overall survival. Other modalities of immunotherapy include antibody therapies, which hold considerable promise and can be categorized into unconjugated classical antibodies, multivalent recombinant antibodies (bi-, tri- and quad-specific), toxin-conjugated antibodies and radio-conjugated antibodies. While unconjugated antibodies can facilitate Natural Killer (NK) cell antibody-dependent cell-mediated cytotoxicity (ADCC), bi- and tri-specific antibodies can engage either NK cells or T-cells to redirect cytotoxicity against AML targets in a highly efficient manner, similarly to classic ADCC. Finally, toxin-conjugated and radio-conjugated antibodies can increase the potency of antibody therapies. Several AML tumour-associated antigens are at the forefront of targeted therapy development, which include CD33, CD123, CD13, CLL-1 and CD38 and which may be present on both AML blasts and leukemic stem cells. This review focused on antibody therapies for AML, including pre-clinical studies of these agents and those that are either entering or have been tested in early phase clinical trials. Antibodies for checkpoint inhibition and microenvironment targeting in AML were excluded from this review.
Best-Evidence for the Rehabilitation of Chronic Pain Part 1: Pediatric Pain
Authors: Harrison Lauren E. , Pate Joshua W. , Richardson Patricia A. , Ickmans Kelly , Wicksell Rikard K. , Simons Laura E.
Published: August 2019

Chronic pain is a prevalent and persistent problem in middle childhood and adolescence. The biopsychosocial model of pain, which accounts for the complex interplay of the biological, psychological, social, and environmental factors that contribute to and maintain pain symptoms and related disability has guided our understanding and treatment of pediatric pain. Consequently, many interventions for chronic pain are within the realm of rehabilitation, based on the premise that behavior has a broad and central role in pain management. These treatments are typically delivered by one or more providers in medicine, nursing, psychology, physical therapy, and/or occupational therapy. Current data suggest that multidisciplinary treatment is important, with intensive interdisciplinary pain rehabilitation (IIPT) being effective at reducing disability for patients with high levels of functional disability. The following review describes the current state of the art of rehabilitation approaches to treat persistent pain in children and adolescents. Several emerging areas of interventions are also highlighted to guide future research and clinical practice.
Systematic Evaluation of Light-Activatable Biohybrids for Anti-Glioma Photodynamic Therapy
Authors: Inglut Collin T. , Baglo Yan , Liang Barry J. , Cheema Yahya , Stabile Jillian , Woodworth Graeme F. , Huang Huang-Chiao
Published: August 2019

Photosensitizing biomolecules (PSBM) represent a new generation of light-absorbing compounds with improved optical and physicochemical properties for biomedical applications. Despite numerous advances in lipid-, polymer-, and protein-based PSBMs, their effective use requires a fundamental understanding of how macromolecular structure influences the physicochemical and biological properties of the photosensitizer. Here, we prepared and characterized three well-defined PSBMs based on a clinically used photosensitizer, benzoporphyrin derivative (BPD). The PSBMs include 16:0 lysophosphocholine-BPD (16:0 Lyso PC-BPD), distearoyl-phosphoethanolamine-polyethylene-glycol-BPD (DSPE-PEG-BPD), and anti-EGFR cetuximab-BPD (Cet-BPD). In two glioma cell lines, DSPE-PEG-BPD exhibited the highest singlet oxygen yield but was the least phototoxic due to low cellular uptake. The 16:0 Lyso PC-BPD was most efficient in promoting cellular uptake but redirected BPD’s subcellular localization from mitochondria to lysosomes. At 24 h after incubation, proteolyzed Cet-BPD was localized to mitochondria and effectively disrupted the mitochondrial membrane potential upon light activation. Our results revealed the variable trafficking and end effects of PSBMs, providing valuable insights into methods of PSBM evaluation, as well as strategies to select PSBMs based on subcellular targets and cytotoxic mechanisms. We demonstrated that biologically informed combinations of PSBMs to target lysosomes and mitochondria, concurrently, may lead to enhanced therapeutic effects against gliomas.
Tendon Adaptations to Eccentric Exercise and the Implications for Older Adults
Authors: Quinlan Jonathan I , Narici Marco V , Reeves Neil D , Franchi Martino V
Published: August 2019

The purpose of this short review is to discuss the effects of eccentric exercise in modifying the properties of tendon tissue in healthy individuals. The tendon provides a mechanical link between muscle and bone, allowing force transmission to the skeleton, and thus, its properties have significant functional implications. Chronic resistance training has long been shown to increase the stiffness and Young’s modulus of the tendon and even tendon cross-sectional area. However, as the tendon responds to the amount and/or frequency of strain, it has been previously suggested that eccentric training may result in greater adaptations due to the potential for greater training loads. Thus, this review discusses the effects of eccentric training upon healthy tendon tissue and compares these to other training modalities. Furthermore, it has been reported that the tendon may undergo adverse age-related changes. Thus, this review also discusses the potential application of eccentric resistance training as a preferential modality for counteracting these age-related changes. We conclude that while there may be no difference between contraction types for overall tendon adaptation, the lower demands of eccentric contractions may make it more appealing for the elderly population.
Effects of the Soil Property Distribution Gradient on the Wave-Induced Response of a Non-Homogeneous Seabed
Authors: Sui Titi , Jin Yu , Wang Zhaojun , Zhang Chi , Shi Jian
Published: August 2019

The seabed is usually non-homogeneous in the real marine environment, and its response to the dynamic wave loading is of great concern to coastal engineers. Previous studies on the simulation of a non-homogeneous seabed response have mostly adopted a vertically layered seabed, in which homogeneous soil properties are assumed in the governing equations for one specified layer. This neglects the distribution gradient terms of soil property, thus leading to an inaccurate evaluation of the dynamic response of a non-homogeneous seabed. In this study, a numerical model for a wave-induced 3D non-homogeneous seabed response is developed, and the effects of the soil property distribution gradient on the wave-induced response of a non-homogeneous seabed are numerically investigated. The numerical model is validated, and the results of the present simulation agree well with those of previous studies. The validated model is applied to simulate an ideal two-dimensional (2D) vertical non-homogeneous seabed. The model is further applied to model the practical wave-induced dynamic response of a three-dimensional (3D) non-homogeneous seabed around a mono-pile. The difference in pore pressure and soil effective stresses due to the soil distribution gradient is investigated. The effects of the soil distribution gradient on liquefaction are also examined. Results of this numerical study indicate that (1) pore pressure decreases while soil effective stresses increase (the maximum difference of the effective stresses can reach 68.9 % p 0 ) with a non-homogeneous seabed if the distribution gradient terms of soil properties are neglected; (2) the effect of the soil property distribution gradient terms on the pore pressure becomes more significant at the upper seabed, while this effect on the soil effective stresses is enhanced at the lower seabed; (3) the effect of the soil distribution gradient on the seabed response is greatly affected by the wave reflection and diffraction around the pile foundation; and (4) the soil distribution gradient terms can be neglected in the evaluation of seabed liquefaction depth in engineering practice.
Molecular Diagnostics in the Times of Surveillance for Candida auris
Authors: Kordalewska Milena , Perlin David S.
Published: August 2019

Recently, global health professionals have been significantly challenged by the emergence of Candida auris and its propensity to colonize human skin, persist in the healthcare environment, and cause healthcare-associated outbreaks. Additionally, C. auris isolates are often characterized by elevated minimal inhibitory concentration (MIC) values for antifungal drugs. Thus, rapid detection and accurate identification of C. auris together with an assessment of potential antifungal drug resistance has become essential for effective patient management, and infection prevention and control in healthcare facilities. Surprisingly, almost all of the commonly available diagnostic tools rely on recovery (growth) of yeast colonies from collected samples, which delays the diagnostic result by several days or longer. To circumvent these issues, molecular-based DNA amplification assays have been developed to identify C. auris DNA directly from patient samples. Moreover, allele discriminating detection probes can be used to rapidly assess validated mechanisms of echinocandin and azole resistance.
Which Cryptocurrencies Are Mostly Traded in Distressed Times?
Authors: Kyriazis Νikolaos A. , Prassa Paraskevi
Published: August 2019

This paper investigates the level of liquidity of digital currencies during the very intense bearish phase in their markets. The data employed span the period from April 2018 until January 2019, which is the second phase of bearish times with almost constant decreases. The Amihud’s illiquidity ratio is employed in order to measure the liquidity of these digital assets. Findings indicate that the most popular cryptocurrencies exhibit higher levels of liquidity during stressed periods. Thereby, it is revealed that investors’ preferences for trading during highly risky times are favorable for well-known virtual currencies in the detriment of less-known ones. This enhances findings of relevant literature about strong and persistent positive or negative herding behavior of investors based on Bitcoin, Ethereum and highly-capitalized cryptocurrencies in general. Notably though, a tendency towards investing in the TrueUSD stablecoin has also emerged.
Universal Molecular Triggers of Stress Responses in Cyanobacterium Synechocystis
Authors: Mironov Kirill , Sinetova Maria , Shumskaya Maria , Los Dmitry
Published: August 2019

Systemic analysis of stress-induced transcription in the cyanobacterium Synechocystis sp. strain PCC 6803 identifies a number of genes as being induced in response to most abiotic stressors (heat, osmotic, saline, acid stress, strong light, and ultraviolet radiation). Genes for heat-shock proteins (HSPs) are activated by all these stresses and form a group that universally responds to all environmental changes. The functions of universal triggers of stress responses in cyanobacteria can be performed by reactive oxygen species (ROS), in particular H2O2, as well as changes in the redox potential of the components of the photosynthetic electron transport chain. The double mutant of Synechocystis sp. PCC 6803 (katG/tpx, or sll1987/sll0755), which is defective in antioxidant enzymes catalase (KatG) and thioredoxin peroxidase (Tpx), cannot grow in the presence of exogenous hydrogen peroxide (H2O2); and it is extremely sensitive to low concentrations of H2O2, especially under conditions of cold stress. Experiments on this mutant demonstrate that H2O2 is involved in regulation of gene expression that responds to a decrease in ambient temperature, and affects both the perception and the signal transduction of cold stress. In addition, they suggest that formation of ROS largely depends on the physical state of the membranes such as fluidity or viscosity. In cyanobacteria, an increase in membrane turnover leads to a decrease in the formation of ROS and an increase in resistance to cold stress. Therefore: (1) H2O2 is the universal trigger of stress responses in cyanobacterial cells; (2) ROS formation (in particular, H2O2) depends on the physical properties of both cytoplasmic and thylakoid membranes; (3) The destructive effect of H2O2 is reduced by increasing of fluidity of biological membranes.
Blueprint and Implementation of Rural Stand-Alone Power Grids with Second-Life Lithium Ion Vehicle Traction Battery Systems for Resilient Energy Supply of Tropical or Remote Regions
Authors: Nedjalkov Antonio , Meyer Jan , Göken Heiko , Reimer Maximilian V. , Schade Wolfgang
Published: August 2019

Developed societies with advanced economic performance are undoubtedly coupled with the availability of electrical energy. Whilst industrialized nations already started to decrease associated carbon emissions in many business sectors, e.g., by substituting combustion engines with battery-powered vehicles, less developed countries still lack broad coverage of reliable electricity supply, particularly in rural regions. Progressive electrification leads to a need for storage capacity and thus to increasing availability of advanced battery systems. To achieve a high degree of sustainability, re-used batteries from the electromobility sector are appropriate, as they do not consume further primary resources and still have sufficient residual capacity for stationary electrical storage applications. In this article, a blueprint for the electrification of a remote region by utilizing second-life lithium ion traction batteries for an integrated energy system in a stand-alone grid is presented and the implementation by the example case of a Tanzanian island in Lake Victoria is demonstrated. First, economic potentials and expected trends in the disposability of second-life lithium ion batteries and their foreseeable costs are outlined. Subsequently, key decision variables are identified to evaluate logistic aspects and the feasibility of the implementation of an off-grid electrical system in remote areas for economically and geographically unfavorable environments. The practical realization is pictured in detail with a focus on technical performance and safety specificities associated with second-life applications. Therefore, a new type of battery management system is introduced, which meets the special requirements of climate compatibility, low maintenance, enhanced cell balancing capability and cell configuration flexibility, and combined with a fiber-optical sensor system, provides reliable status monitoring of the battery. By carrying out on-site measurements, the overall system efficiency is evaluated along with a sustainability analysis. Finally, the socioeconomic and humanitarian impact for the people on the island is debated.
Linguistic Picture Fuzzy Dombi Aggregation Operators and Their Application in Multiple Attribute Group Decision Making Problem
Authors: Qiyas Muhammad , Abdullah Saleem , Ashraf Shahzaib , Abdullah Lazim
Published: August 2019

The aims of this study are to propose the linguistic picture fuzzy Dombi (LPFD) aggregation operators and decision-making approach to deal with uncertainties in the form of linguistic picture fuzzy sets. LPFD operators have more flexibility due to the general fuzzy set. Utilizing the Dombi operational rule, the series of Dombi aggregation operators were proposed, namely linguistic picture fuzzy Dombi arithmetic/geometric, ordered arithmetic/ordered geometric and Hybrid arithmetic/Hybrid geometric aggregation operators. The distinguished feature of these proposed operators is studied. At that point, we have used these Dombi operators to design a model to deal with multiple attribute decision-making (MADM) issues under linguistic picture fuzzy information. Finally, an illustrative example to evaluate the emerging technology enterprises is provided to demonstrate the effectiveness of the proposed approach, together with a sensitivity analysis and comparison analysis, proving that its results are feasible and credible.
Optimization of Queueing Model with Server Heating and Cooling
Authors: Dudina Olga , Dudin Alexander
Published: August 2019

The operation of many real-world systems, e.g., servers of data centers, is accompanied by the heating of a server. Correspondingly, certain cooling mechanisms are used. If the server becomes overheated, it interrupts processing of customers and needs to be cooled. A customer is lost when its service is interrupted. To prevent overheating and reduce the customer loss probability, we suggest temporal termination of service of new customers when the temperature of the server reaches the predefined threshold value. Service is resumed after the temperature drops below another threshold value. The problem of optimal choice of the thresholds (with respect to the chosen economical criterion) is numerically solved under quite general assumptions about the parameters of the system (Markovian arrival process, phase-type distribution of service time, and accounting for customers impatience). Numerical examples are presented.
Thromboembolic Events Following Atrial Fibrillation Cardioversion and Ablation: What’s the Culprit?
Authors: De Sensi Francesco , Miracapillo Gennaro , Addonisio Luigi , Breschi Marco , Cresti Alberto , Baratta Pasquale , Paneni Francesco , Limbruno Ugo
Published: August 2019

Stroke is a rare but possible complication after atrial fibrillation (AF) ablation. However, its etiopathogenesis is far from being completely characterized. Here we report a case of stroke, with recurrent peripheral embolism after AF ablation procedure. In our patient, an in situ femoral vein thrombosis and iatrogenic atrial septal defect were simultaneously detected. A comprehensive review of multiple pathophysiological mechanisms of stroke in this context is provided. The case underlines the importance of a global evaluation of patients undergoing AF ablation.
Role of Obesogens in the Pathogenesis of Obesity
Authors: Shahnazaryan Urszula , Wójcik Marta , Bednarczuk Tomasz , Kuryłowicz Alina
Published: August 2019

Obesity is considered to be a 20th century pandemic, and its prevalence correlates with the increasing global pollution and the presence of chemical compounds in the environment. Excessive adiposity results from an imbalance between energy intake and expenditure, but it is not merely an effect of overeating and lack of physical activity. Recently, several compounds that alter the mechanisms responsible for energy homeostasis have been identified and called “obesogens”. This work presents the role of obesogens in the pathogenesis of obesity. We reviewed data from in vitro animal and human studies concerning the role of obesogens in the disturbance of energy homeostasis. We identified (i) the main groups and classes of obesogens, (ii) the molecular mechanisms of their action, (iii) their deleterious effect on adipose tissue function and control of appetite, and (iv) possible directions in limiting their influence on human metabolism. Obesogens have a multifactorial detrimental influence on energy homeostasis. Focusing on limiting exposure to obesogens and improving early life nutrition seems to be the most reasonable direction of action to prevent obesity in future generations.