bluuebunny/crossref_metadata_2025 huggingface dataset:
Recent Advances in Batteryless NFC Sensors for Chemical Sensing and Biosensing
Authors: Lazaro Antonio , Villarino Ramon , Lazaro Marc , Canellas Nicolau , Prieto-Simon Beatriz , Girbau David
Published: July 2023

This article reviews the recent advances in the field of batteryless near-field communication (NFC) sensors for chemical sensing and biosensing. The commercial availability of low-cost commercial NFC integrated circuits (ICs) and their massive integration in smartphones, used as readers and cloud interfaces, have aroused great interest in new batteryless NFC sensors. The fact that coil antennas are not importantly affected by the body compared with other wireless sensors based on far-field communications makes this technology suitable for future wearable point-of-care testing (PoCT) devices. This review first compares energy harvesting based on NFC to other energy-harvesting technologies. Next, some practical recommendations for designing and tuning NFC-based tags are described. Power transfer is key because in most cases, the energy harvested has to be stable for several seconds and not contaminated by undesired signals. For this reason, the effect of the dimensions of the coils and the conductivity on the wireless power transfer is thoroughly discussed. In the last part of the review, the state of the art in NFC-based chemical and biosensors is presented. NFC-based tags (or sensor tags) are mainly based on commercial or custom NFC ICs, which are used to harvest the energy from the RF field generated by the smartphone to power the electronics. Low-consumption colorimeters and potentiostats can be integrated into these NFC tags, opening the door to the integration of chemical sensors and biosensors, which can be harvested and read from a smartphone. The smartphone is also used to upload the acquired information to the cloud to facilitate the internet of medical things (IoMT) paradigm. Finally, several chipless sensors recently proposed in the literature as a low-cost alternative for chemical applications are discussed.
Recent Advances of Metal–Polyphenol Coordination Polymers for Biomedical Applications
Authors: Qin Jing , Guo Ningning , Yang Jia , Chen Yong
Published: July 2023

Nanomedicine has provided cutting-edge technologies and innovative methods for modern biomedical research, offering unprecedented opportunities to tackle crucial biomedical issues. Nanomaterials with unique structures and properties can integrate multiple functions to achieve more precise diagnosis and treatment, making up for the shortcomings of traditional treatment methods. Among them, metal–polyphenol coordination polymers (MPCPs), composed of metal ions and phenolic ligands, are considered as ideal nanoplatforms for disease diagnosis and treatment. Recently, MPCPs have been extensively investigated in the field of biomedicine due to their facile synthesis, adjustable structures, and excellent biocompatibility, as well as pH-responsiveness. In this review, the classification of various MPCPs and their fabrication strategies are firstly summarized. Then, their significant achievements in the biomedical field such as biosensing, drug delivery, bioimaging, tumor therapy, and antibacterial applications are highlighted. Finally, the main limitations and outlooks regarding MPCPs are discussed.
Detection of Alzheimer’s Disease Using Logistic Regression and Clock Drawing Errors
Authors: Lazarova Sophia , Grigorova Denitsa , Petrova-Antonova Dessislava ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: July 2023

Alzheimer’s disease is an incurable disorder that accounts for up to 70% of all dementia cases. While the prevalence of Alzheimer’s disease and other types of dementia has increased by more than 160% in the last 30 years, the rates of undetected cases remain critically high. The present work aims to address the underdetection of Alzheimer’s disease by proposing four logistic regression models that can be used as a foundation for community-based screening tools that do not require the participation of medical professionals. Our models make use of individual clock drawing errors as well as complementary patient data that is highly available and easily collectible. All models were controlled for age, education, and gender. The discriminative ability of the models was evaluated by area under the receiver operating characteristic curve (AUC), the Hosmer-Lemeshow test, and calibration plots were used to assess calibration. Finally, decision curve analysis was used to quantify clinical utility. We found that among 10 possible CDT errors, only 3 were informative for the detection of Alzheimer’s disease. Our base regression model, containing only control variables and clock drawing errors, produced an AUC of 0.825. The other three models were built as extensions of the base model with the step-wise addition of three groups of complementary data, namely cognitive features (semantic fluency score), genetic predisposition (family history of dementia), and cardio-vascular features (BMI, blood pressure). The addition of verbal fluency scores significantly improved the AUC compared to the base model (0.91 AUC). However, further additions did not make a notable difference in discriminatory power. All models showed good calibration. In terms of clinical utility, the derived models scored similarly and greatly outperformed the base model. Our results suggest that the combination of clock symmetry and clock time errors plus verbal fluency scores may be a suitable candidate for developing accessible screening tools for Alzheimer’s disease. However, future work should validate our findings in larger and more diverse datasets.
Differences in the EEG Power Spectrum and Cross-Frequency Coupling Patterns between Young and Elderly Patients during Sevoflurane Anesthesia
Authors: Zhang Xinxin , Li Ao , Wang Sa , Wang Tingting , Liu Tiantian , Wang Yonghui , Fu Jingwen , Zhao Guangchao , Yang Qianzi , Dong Hailong
Published: July 2023

Electroencephalography (EEG) is widely used for monitoring the depth of anesthesia in surgical patients. Distinguishing age-related EEG features under general anesthesia will help to optimize anesthetic depth monitoring during surgery for elderly patients. This retrospective cohort study included 41 patients aged from 18 to 79 years undergoing noncardiac surgery under general anesthesia. We compared the power spectral signatures and phase–amplitude coupling patterns of the young and elderly groups under baseline and surgical anesthetic depth. General anesthesia by sevoflurane significantly increased the spectral power of delta, theta, alpha, and beta bands and strengthened the cross-frequency coupling both in young and elderly patients. However, the variation in EEG power spectral density and the modulation of alpha amplitudes on delta phases was relatively weaker in elderly patients. In conclusion, the EEG under general anesthesia using sevoflurane exhibited similar dynamic features between young and elderly patients, and the weakened alteration of spectral power and cross-frequency coupling patterns could be utilized to precisely quantify the depth of anesthesia in elderly patients.
Application of the Semantic Fluency Test in the Screening of Mandarin-Chinese-Speaking Older Adults with Mild Dementia of the Alzheimer Type
Authors: Lin Ming-Ching , Chih Yu-Chun
Published: July 2023

Semantic fluency tests have been widely used as a screening test for dementia of Alzheimer type. However, few studies have explored the application of semantic fluency tests in Mandarin Chinese speakers. This study aimed to explore the feasibility of using different semantic fluency test categories to distinguish between older adults without cognitive impairments and those with dementia of Alzheimer type in Taiwan. A total of 58 healthy older adults and 54 individuals with dementia of Alzheimer type were recruited. Semantic categories of “animals”, “fruits”, “vegetables”, “birds”, “means of transportations” and “musical instruments” were administered to participants. The scores from two groups of participants for each category were analyzed. Significant differences in the test scores of each category between two groups of participants were found. The results also revealed that the variables related to whether the participant had dementia, gender, age, and years of schooling significantly influenced the semantic fluency scores for each category. Among all the demographic characteristic of participants, the diagnosis of dementia was the most determining factor. Furthermore, this study proposed optimal cutoff points and calculated the AUC for various test durations (i.e., 30 s, 45 s and 60 s) and semantic categories in the semantic fluency test, which may serve as a reference that would help clinical personnel distinguish between older adults without cognitive impairments and those with dementia of Alzheimer type in Taiwan.
Spatial Configuration Effects on the Dissociation between Active and Latent States in Visual Working Memory
Authors: Li Ziyuan , Liu Qiang
Published: July 2023

Visual working memory includes both active, recallable items and latent items not directly available for recall. During the online manipulation of active working memory, latent items gain robust retention. According to the dissociation account, active and passive memories exist in independent states, both of which take up their own cognitive resources. However, it is unclear whether dissociation is a universal phenomenon during memory maintenance. Given that memory information is retained as a binding of identity and location, the spatial proximity of memory items might shield the dissociation property. To test this, we adopted a retro-cue memory task where the cued and uncued items were separated in the active and latent states. In Experiment 1, the memory items were presented at a relatively large spatial distance. The results supported the dissociation account for well-separated items. However, Experiment 2 rejected the dissociation for closer-in items, possibly because items in visual working memory were spatially labeled. These findings suggest that while memory maintenance generally conforms to the dissociation account, the spatial configuration of memory items can affect the dissociation property between the active and latent neural states in visual working memory.
Effect of Space Order on Impulse Buying: Moderated by Self-Construal
Authors: Shi Yi , Joo Jaewoo
Published: July 2023

Objective: Impulse buying is a recognized phenomenon as consumers have abundant shopping opportunities. We investigate whether orderly space encourages consumers to buy impulsively and whether this relationship is moderated by self-construal. Specifically, we hypothesize that consumers show greater impulse buying intentions when space is orderly than disorderly. We also hypothesize that when interdependent self-construal is primed, the effect of orderly space on consumers’ increased impulse buying intentions will be attenuated. Background: Our hypotheses are based on the research about emotions that consumers experience while they shop in a retail store. When the store is orderly, consumers experience pleasure. In contrast, disorganized shelves, unsorted merchandise, and messy clothing racks evoke negative emotions. A recent study shows consumers’ positive emotional responses to a retail environment result in heightened impulse buying. Methods: Two experiments were carried out to test the two hypotheses. Experiment 1 employed a 2 (space order: orderly vs. disorderly) between-subjects design. Participants randomly received one of the two store images and were asked to indicate their impulse-buying intentions. Experiment 2 employed a 2 (space order: orderly vs. disorderly) × 2 (self-construal: independent vs. interdependent) between-subjects design. Participants were randomly given one of the two store images and one of the two self-construal priming tasks to measure their impulse buying intentions. Results: As hypothesized, Experiment 1 demonstrated that participants exerted stronger impulse-buying intentions in an orderly space. Experiment 2 also showed that when participants were primed by interdependent self-construal, their impulse buying intentions did not differ, regardless of whether the space was orderly. Implications: Our findings provide insights for offline store managers. To nudge visitors to buy impulsively, managers should organize their spaces orderly. However, the effect of space order on consumers’ impulse buying will disappear when consumers’ interdependent self-construal is activated. Our findings contribute to the academic research into the factors that lead consumers to buy impulsively.
Building Information Modelling (BIM) Driven Sustainable Cultural Heritage Tourism
Authors: Liu Zhen , Zhang Man , Osmani Mohamed
Published: July 2023

At present, incorrect or aggressive conservation efforts harm not only the building heritage, but also its cultural significance and authenticity. There is an urgent need to investigate existing studies that utilise proper methods and processes of the digital economy and technology to promote sustainable architecture and building heritage conservation and heritage tourism development and management to achieve the United Nations sustainable development goals (SDGs). Hence, this paper aims to explore the role of digital economy technology, i.e., building information modelling (BIM), in promoting the harmonious development of cultural architectural and building heritage conservation and sustainable cultural heritage tourism, as well as to reveal the current state of the research and hotspots in BIM-driven cultural heritage conservation for sustainable cultural heritage tourism. A mix of a macro-quantitative bibliometric method and a follow-up micro-qualitative content analysis method has been employed to highlight the significance and promise of the interdisciplinary domains of BIM, cultural heritage conservation, and sustainable cultural heritage tourism to the attainment of SDG 11 (sustainable cities and communities) focused on three specific goals, i.e., enhance inclusive and sustainable urbanisation (SDG 11.3), strengthen efforts to protect and safeguard the world’s cultural and natural heritage (SDG 11.4), and reduce the adverse per capita environmental impact of cities (SDG 11.6); and SDG 17 (partnerships) regarding four issues, i.e., stakeholder relationships, public participation, heritage conservation experts, and management. Additionally, three categories of research themes have been identified: cultural heritage conservation, heritage and tourism management, and support of emerging technology. Furthermore, the relationships between BIM and sustainable cultural heritage tourism from the last 26 years (1997 to 2022) have been revealed with visualisations of future research trends in BIM, cultural heritage conservation, and sustainable cultural heritage tourism.
Daylighting Assessment of a Heritage Place of Instruction and Office Building in Alice, South Africa
Authors: Overen Ochuko K. , Meyer Edson L. , Makaka Golden
Published: July 2023

Mitigation of post-occupancy building energy consumption has resulted in the change of building design to utilise ambient weather factors for indoor thermal conditioning and lighting. This has increased the construction of new buildings with large glazing façades and reduced adaptive use of heritage buildings as they are considered not designed to meet modern energy use requirements. This paper evaluates the daylighting performance of a heritage place of instruction and office building. A quantitative research approach based on building information simulation tools was adopted. Autodesk Revit 2021 and Integrated Environmental Solutions Virtual Environment (IESVE) 2021 were used in modelling and simulating the building daylighting performances. The building’s annual daylight performance analysed with climate-based daylight modelling shows that points in the analysed spaces were within the UDI300-2000 for more than 50% of the occupied period (07h00 to 17h00) in a year. The sDA300,50% was found to be 100% in most spaces, which is considered a favourable daylit space according to the Illuminance Engineering Society of North America (IESNA). Further, discomfort glare analysis revealed that the building daylight glare is imperceptible, with an average daylight glare probability of 21.2%. The 1:14 window–wall ratio contributes to the building daylighting relative to orientation without constituting visual discomfort. Overall, climate-based daylight modelling revealed that the building’s annual daylight level meets the IESNA requirements with an imperceptible daylight glare.
Acoustic Performance Investigation of a CLT-Based Three-Floor Building
Authors: Guigou Carter Catherine , Balanant Nicolas , Kouyoumji Jean-Luc
Published: July 2023

The acoustic performance of a CLT-based building mockup was investigated within the scope of the ADIVBois acoustic technical commission with the objective of defining wood building constructions fulfilling requirements. The CLT-based building is a three-floor construction with four rooms on each level. Measurements from junction characterization to airborne and impact sound insulations were taken. The implemented floor systems were first tested in a laboratory to evaluate their acoustic performance. Predictions based on the EN ISO 12354-1 and -2 standards were compared to building acoustic measurements. The effect of using the tapping machine and the rubber ball as impact sources was investigated both in laboratory and in the CLT-based building mockup. The effect of the apparent post between rooms is also presented with an associated simple approach to take it into account in predictions. This paper summarizes the obtained results.
An Experimental Study on Human Thermal Comfort with Thermal-Conductive Bed during Sleep in Summer
Authors: Hu Jinhua , Hao Xiaoli , Huang Minhua , He Yingdong , Li Nianping , Lin Yaolin , Chen Shiqiang
Published: July 2023

Sleep is vital for human health, while sleep quality is affected by indoor thermal environments. This study aims to investigate human thermal comfort with a thermal-conductive bed during sleep in summer. A series of experiments were conducted in a climatic chamber of a university. Subjects slept on a thermal-conductive bed, with or without the supply of water cooling them by flowing through the pipes embedded in the bed. The supply water was set at 20, 25, 28, and 30 °C. The indoor temperature was set at 32 °C. The bed surface temperature (back, buttock, thigh, and calf) and the subject’s skin temperature were measured. Questionnaires after waking up the next morning were conducted. The results show that when there was no water supply in the pipes of the thermal-conductive bed, the bed surface temperature was 0–1.5 °C higher than the indoor temperature, and subjects felt slightly warm. When the supply water temperature was 28 or 30 °C, subjects felt thermally comfortable during a night’s sleep. This study demonstrates that the proposed thermal-conductive bed with supply water temperatures of 28–30 °C can create a comfortable sleep environment for residents who have no air-conditioning systems in summer, which can also help save building energy.
The Green Dimension of a Compact City: Temperature Changes in the Urban Area of Banja Luka
Authors: Okilj Una , Čvoro Malina , Čvoro Saša , Uljarević Zoran
Published: July 2023

Responsible and rational urban planning is reflected in an integral and multidimensional approach to city development. Contemporary theories of sustainable and resilient urban planning support a clear vision and strategy for city development, emphasizing its identity, specifics, and values. Through its vision and action plans, the city of Banja Luka protects its default identity as a green city while recognizing the current development trend toward a compact city. The paper deals with two theories: green and compact cities, both motivated by ecological and energy planning. The paper aims to show the importance of the green dimension of a compact city and the adoption of the principles of compactness in the green city in order to examine its contribution through synergistic action. Through the comparative analysis of the green structure change toward a compact urban area and temperature rise in the last fifty years and on different scales, it is possible to question the set green goals and effects of environmental urban (non) planning.
Systematic Training to Improve the Transformation of Migrant Workers into Industrial Workers within the Construction Sector in China
Authors: Ke Yanyan , Bian Jing
Published: July 2023

The transformation and modernization of the construction industry in China has introduced higher knowledge, skill, literacy, and innovation ability requirements for construction workers. Subsequently, more than 53 million migrant workers, comprising the main workforce of China’s construction sector, require transitioning into the roles of high-quality and highly skilled construction industry workers. As an important means to improve human capital, systematic training is the key method for the development of migrant workers into industrial workers within China’s construction industry. This paper constructs and verifies the theoretical model underlying the operating mechanism of the training system for migrant workers within the construction industry. As such, a structural equation model was established for the mechanism of transforming construction migrant workers into industrial workers. The results show that as the driving forces, the government and construction industry play important roles in promoting the operation of the training system for migrants in the construction industry as they provide internal vocational and social training. Construction enterprises have a direct role in promoting professional literacy training as one of the direct beneficiaries of construction workers’ training. Therefore, this paper provides a critical reference for policy promoting the transformation of migrant workers into industrial workers through appropriate training within China’s construction industry.
Behaviour of Steel-Concrete-Steel Sandwich Beams with Novel Enhanced C-Channels
Authors: Ayyadurai Ananthakumar , Shanmugam Balaji , Ravindran Gobinath
Published: July 2023

As the load increases, most composite beams generally experience failure in both shear and flexural behavior. This outcome highlights the critical challenges of achieving sufficient strength and structural integrity in such beams. The proposed study has used the cold-formed behavior of an Enhanced C-channel (EC) shear connectors and Light Weight Concrete (LWC) to examine the new Steel-Lightweight Concrete-Steel sandwich Beams (SLCSB). The ECs have provided significant shear resistance at the faceplate-LWC interfacial interface and the tension separation resistance for faceplates (cold form steel) from the LWC core. Cold Form Steel (CFS) is the most often used substitute because of its high productivity and practicality in the field. Four different composite beams are examined in the proposed research with different ECs spacing. The beams’ top and bottom face plates are covered using CFS (1.6 mm). In addition to that, two different types of shear connectors are used. Two unique longitudinal spacing of 100 mm and 150 mm are also used for one with lipped ECs and without lipped ECs. Importantly, self-tapping screws are used to secure ECs in place between the top and bottom of the face plates. The effectiveness of the composite beams with various shear connector spacing subjected to a two-point load test is assessed through a series of experiments.
Distinct Lineage of Slow-Cycling Cells Amidst the Prevailing Heterogeneity in Glioblastoma
Authors: Mahajan Sukrit , Schmidt Mirko H. H.
Published: July 2023

Glioblastoma (GBM) is the most aggressive form of primary brain tumor in adults [...]
Automated Capture and Analysis of Circulating Tumor Cells in Pediatric, Adolescent and Young Adult Patients with Central Nervous System Tumors
Authors: Zaky Wafik , Ragoonanan Dristhi , Batth Izhar , Dao Long , Wang Jian , Xia Xueqing , Daw Najat C. , Gill Jonathan B. , Khatua Soumen , Li Shulin
Published: July 2023

Tumors of the central nervous system (CNS) are the most common and lethal childhood malignancy. Detection of residual disease and longitudinal monitoring of treatment response in patients are challenging and rely on serial imaging. This current standard of care fails to detect microscopic disease or provide molecular characteristics of residual tumors. As such, there is dire need for minimally invasive liquid biopsy techniques. We have previously shown the high specificity of using cell surface vimentin (CSV) to identify circulating tumor cells (CTCs) from patients bearing various types of cancers. Here, we describe the first report of CTCs captured from peripheral blood samples in 58 pediatric CNS tumor patients. In this study, we used a CSV-coated cell capture chip, the Abnova CytoQuest automated CTC isolation system, to boost the CTC capture from pediatric patients with CNS tumors. We successfully isolated CTCs in six glioma patients using immunostaining of histone H3 lysine27-to-methionine (H3K27M) mutations which are highly expressed by this tumor. We show that CSV is a viable marker for CNS CTC isolation and that this is a feasible method for detecting microscopic disease. Larger-scale studies focusing on CTCs in pediatric CNS tumors to explore their diagnostic and prognostic value are warranted.
The Evolving Landscape of Cytoreductive Nephrectomy in Metastatic Renal Cell Carcinoma
Authors: Studentova Hana , Spisarova Martina , Kopova Andrea , Zemankova Anezka , Melichar Bohuslav , Student Vladimir
Published: July 2023

The role of cytoreductive nephrectomy in metastatic renal cell carcinoma (RCC) has been studied intensively over the past few decades. Interestingly, the opinion with regard to the importance of this procedure has switched from a recommendation as a standard of care to an almost complete refutation. However, no definitive agreement on cytoreductive nephrectomy, including the pros and cons of the procedure, has been reached, and the topic remains highly controversial. With the advent of immune checkpoint inhibitors, we have experienced a paradigm shift, with immunotherapy playing a crucial role in the treatment algorithm. Nevertheless, obtaining results from prospective clinical trials on the role of cytoreductive nephrectomy requires time, and once some data have been gathered, the standards of systemic therapy may be different, and we stand again at the beginning. This review summarizes current knowledge on the topic in the light of newly evolving treatment strategies. The crucial point is to recognize who could be an appropriate candidate for immediate cytoreductive surgery that may facilitate the effect of systemic therapy through tumor debulking, or who might benefit from deferred cytoreduction in the setting of an objective response of the tumor. The role of prognostic factors in management decisions as well as the technical details associated with performing the procedure from a urological perspective are discussed. Ongoing clinical trials that may bring new evidence for transforming therapeutic paradigms are listed.
Delivering Palliative and Supportive Care for Older Adults with Cancer: Interactions between Palliative Medicine and Geriatrics
Authors: Castelo-Loureiro Alicia , Perez-de-Acha Andrea , Torres-Perez Ana Cristina , Cunha Vanessa , García-Valdés Paola , Cárdenas-Reyes Paula , Soto-Perez-de-Celis Enrique
Published: July 2023

The world’s population is aging rapidly, with projections indicating that by 2050 one in six people will be aged ≥65 years. As a result, the number of cancer cases in older people is expected to increase significantly. Palliative care is an essential component of cancer care with a direct impact on quality of life. However, older adults with cancer often suffer from multiple comorbidities, cognitive impairment, and frailty, posing unique challenges in the delivery of palliative care. The complex healthcare needs of older patients with cancer therefore require a comprehensive assessment, including a geriatric evaluation. Collaboration between geriatrics and palliative care can offer a solution to the challenges faced by older people with cancer, since this is a population with overlapping concerns for both disciplines. This review highlights the importance of palliative care for older adults with cancer and the benefits of a multidisciplinary approach. It also addresses the coordination of palliative care and geriatrics for specific symptom management and decision making.
First-Line Treatment of Older Patients with CLL: A New Approach in the Chemo-Free Era
Authors: Urso Antonio , Cavazzini Francesco , Ballardini Maria Pia , Gambara Silvia , Consolo Sara , Rigolin Gian Matteo , Cuneo Antonio
Published: July 2023

Bruton tyrosine kinase inhibitors (BTKi) and the BCL2 inhibitor venetoclax, with or without the anti-CD20 monoclonal antibody Obinutuzumab, represent the preferred options for the first-line therapy of CLL because they are more effective and may improve quality of life. However, patient inclusion criteria are heterogeneous across trials designed for older patients, and the identification of CLL-specific parameters identifying unfit patients at risk of developing drug-specific adverse events is required to guide treatment choice. Due to inclusion/exclusion criteria in trials, higher discontinuation rates with BTKi were reported in real-world studies, and registry analyses provided useful information on factors predicting earlier discontinuation in a real-world setting. Though targeted agents were shown to be cost-effective treatments in high-income countries, the out-of-pocket expenses may limit accessibility to these drugs, and the overall expenditure for new drugs in CLL is projected to increase substantially, posing an issue for sustainability. This being said, the choice of a finite-duration treatment based on venetoclax-containing regimens or treatment until progression with BTKi is today possible in high-income countries, and the therapy choice drivers are represented by coexisting medical conditions rather than age, patient expectations, logistics, and sustainability.
Young Adult Caregiving Daughters and Diagnosed Mothers Navigating Breast Cancer Together: Open and Avoidant Communication and Psychosocial Outcomes
Authors: Fisher Carla L. , Campbell-Salome Gemme , Bagautdinova Diliara , Wright Kevin B. , Forthun Larry F. , Bacharz Kelsey C. , Mullis M. Devyn , Wolf Bianca , Pereira Deidre B. , Spiguel Lisa , Bylund Carma L.
Published: July 2023

For many diagnosed mothers and their daughters, breast cancer is a shared experience. However, they struggle to talk about cancer. This is particularly true when the daughter is in adolescence or young adulthood, as they tend to be more avoidant, which is associated with poorer biopsychosocial outcomes. When daughters are their mother’s caregivers, daughters’ burden and distress are heightened. Young adult caregiving daughters (YACDs) are the second most common family caregiver and encounter more distress and burden than other caregiver types. Yet, YACDs and their diagnosed mothers receive no guidance on how to talk about cancer. Thirty-nine mother/YACD pairs participated in an online survey to identify challenging topics and strategies for talking about cancer, and to explore associations between openness/avoidance and psychosocial outcomes. YACDs and mothers reported the same challenging topics (death, treatment-related issues, negative emotions, relational challenges, YACDs’ disease risk) but differed on why they avoided the topic. YACDs and mothers identified the same helpful approaches to navigate conversations (openness, staying positive, third-party involvement, avoidance). Avoidance was correlated with more distress whereas openness was correlated with better psychosocial outcomes. These results provide a psychosocial map for a mother-YACD communication skills intervention, which is key to promoting healthy outcomes.
Tumor and Nodal Disease Growth Rates in Patients with Oropharyngeal Squamous Cell Carcinoma
Authors: Farber Nicole I. , Li Yimin , Solis Roberto N. , Chen Joy , Masheeb Zahrah , Wilson Machelle , Bewley Arnaud F. , Abouyared Marianne , Rao Shyam , Rong Yi , Birkeland Andrew C.
Published: July 2023

Though specific growth rate (SGR) has potential prognostic value for oropharyngeal squamous cell carcinoma (OPSCC), there is sparse literature defining these rates. Our aims were to establish the SGRs of primary tumors (PTs) and lymph nodes (LNs) in OPSCC and to correlate SGR with oncologic outcome. A pilot study was designed with a retrospective analysis examining 54 patients from the University of California, Davis with OPSCC (diagnosed 2012–2019). Radiation oncology software and pretreatment serial CT scans were used to measure PT and LN volumes to calculate SGR and doubling time (DT). The mean PT-SGR was 1.2 ± 2.2%/day and the mean LN-SGR was 1.6 ± 1.9%/day. There was no statistically significant difference between slow-growing and fast-growing cohorts in terms of age, gender, smoking status, tumor subsite, HPV status (as determined with p16 staining), initial volume, or overall stage. SGR had no impact on 2-year overall survival, disease-free survival, or disease-specific survival. We found the average daily growth rates for OPSCC to be 1.2%/day and 1.6%/day. Our findings suggest PT- and LN-SGR are independent factors, not heavily influenced by known biomarkers and patient characteristics, without a statistical impact on prognosis. This information has value in patient counseling regarding tumor growth and in providing patients worried about fast-growing tumors the appropriate reassurance.
The Multikinase Inhibitor AD80 Induces Mitotic Catastrophe and Autophagy in Pancreatic Cancer Cells
Authors: Lima Keli , de Miranda Lívia Bassani Lins , Del Milagro Bernabe Garnique Anali , de Almeida Bruna Oliveira , do Nascimento Mariane Cristina , Alcântara Guilherme Augusto Sousa , Machado-Santelli Glaucia Maria , Rego Eduardo Magalhães , Machado-Neto João Agostinho
Published: July 2023

Significant advances in understanding the molecular complexity of the development and progression of pancreatic cancer have been made, but this disease is still considered one of the most lethal human cancers and needs new therapeutic options. In the present study, the antineoplastic effects of AD80, a multikinase inhibitor, were investigated in models of pancreatic cancer. AD80 reduced cell viability and clonogenicity and induced polyploidy in pancreatic cancer cells. At the molecular level, AD80 reduced RPS6 and histone H3 phosphorylation and induced γH2AX and PARP1 cleavage. Additionally, the drug markedly decreased AURKA phosphorylation and expression. In PANC-1 cells, AD80 strongly induced autophagic flux (consumption of LC3B and SQSTM1/p62). AD80 modulated 32 out of 84 autophagy-related genes and was associated with vacuole organization, macroautophagy, response to starvation, cellular response to nitrogen levels, and cellular response to extracellular stimulus. In 3D pancreatic cancer models, AD80 also effectively reduced growth independent of anchorage and cell viability. In summary, AD80 induces mitotic aberrations, DNA damage, autophagy, and apoptosis in pancreatic cancer cells. Our exploratory study establishes novel targets underlying the antineoplastic activity of the drug and provides insights into the development of therapeutic strategies for this disease.
Clinical Possibility of Caenorhabditis elegans as a Novel Evaluation Tool for Esophageal Cancer Patients Receiving Chemotherapy: A Prospective Study
Authors: Sato Yuta , Futamura Manabu , Tanaka Yoshihiro , Tsuchiya Hiroshi , Fukada Masahiro , Higashi Toshiya , Yasufuku Itaru , Asai Ryuichi , Tajima Jesse Yu , Kiyama Shigeru , Hatakeyama Hideyuki , Morishita Masayo , Hirotsu Takaaki , Luccio Eric di , Ishihara Takuma , Matsuhashi Nobuhisa , Yoshida Kazuhiro
Published: July 2023

Background: The nematode Caenorhabditis elegans (C. elegans) possesses a sophisticated sense of smell and is used for a novel cancer screening test that utilizes the chemotaxis index. We designed a single-institution, prospective study to confirm the ability of Nematode Nose (N-NOSE) to determine preoperative chemotherapy’s efficacy for esophageal cancer patients. Patients and Methods: We investigated the predictability of N-NOSE screening for the clinical effects of preoperative chemotherapy for esophageal cancer patients receiving radical surgery. The index reduction score (IRS) was calculated via the chemotaxis of C. elegans at three points: before treatment, before surgery, and after surgery, and its clinical relevance was examined. Result: Thirty-nine patients with esophageal cancer were enrolled from August 2020 to December 2021, and 30 patients receiving radical surgery were examined. Complete response or partial response was achieved in 23 cases (76.7%). When the target of the treatment effect was complete response only, the prediction accuracies of the IRS calculated by area under the curve was 0.85 (95% Confidence interval: 0.62–1) in clinically achieving complete response group, and the sensitivity and specificity were 1 and 0.63, respectively. Conclusion: Index reduction score using N-NOSE screening may reflect the efficacy of chemotherapy for esophageal cancer patients. A large-scale prospective study at multiple centers is desired in the future.
Endoscopic Treatment of T1 Colorectal Cancer
Authors: Metter Klaus , Weißinger Stephanie Ellen , Várnai-Händel Alinda , Grund Karl-Ernst , Dumoulin Franz Ludwig
Published: July 2023

Commonly accepted criteria for curative resection of T1 colorectal cancer include R0 resection with horizontal and vertical clear margins (R0), absence of lympho-vascular or vessel infiltration (L0, V0), a low to moderate histological grading (G1/2), low tumor cell budding, and limited (<1000 µm) infiltration into the submucosa. However, submucosal infiltration depth in the absence of other high-risk features has recently been questioned as a high-risk situation for lymph-node metastasis. Consequently, endoscopic resection techniques should focus on the acquisition of qualitatively and quantitively sufficient submucosal tissue. Here, we summarize the current literature on lymph-node metastasis risk after endoscopic resection of T1 colorectal cancer. Moreover, we discuss different endoscopic resection techniques with respect to the quality of the resected specimen.
Treatment and Prognosis of Patients with Lung Cancer and Combined Interstitial Lung Disease
Authors: Mauclet Charlotte , Dupont Michaël V. , Roelandt Kerwin , Regnier Maxime , Delos Monique , Pirard Lionel , Vander Borght Thierry , Dahlqvist Caroline , Froidure Antoine , Rondelet Benoît , Vanderick Jean , Remouchamps Vincent , Duplaquet Fabrice , Ocak Sebahat
Published: July 2023

Background: Interstitial lung disease (ILD) is associated with a higher lung cancer (LC) risk and may impact cancer’s clinical characteristics, treatment strategies, and outcomes. This impact’s extent is unclear, particularly in Caucasians. Methods: In this retrospective observational study, we reviewed the files of all LC patients diagnosed in a 38-month period. Expert radiologists reviewed the computed tomography scans performed at diagnosis. Patients with LC and ILD (n = 29, 7%) were compared to those without ILD (n = 363, 93%) for population and cancer characteristics, treatments, and clinical outcomes. Results: Patients with LC and ILD were older (73 ± 8 vs. 65 ± 11 years; p < 0.001). There was no significant difference in LC histology, localization, stage, or treatment modalities. The respiratory complication rate after cancer treatment was significantly higher in the ILD group (39% vs. 6%; p < 0.01). Overall survival rates were similar at 12 (52% vs. 59%; p = 0.48) and 24 months (41% vs. 45%; p = 0.64) but poorer in the ILD group at 36 months, although not statistically significant (9% vs. 39%; p = 0.06). The ILD group had a higher probability of death (hazard ratio (HR) = 1.49 [0.96;2.27]), but this was not statistically significant (p = 0.06). In a Cox regression model, patients with ILD treated surgically had a significantly higher mortality risk (HR = 2.37 [1.1;5.09]; p = 0.03). Conclusions: Patients with combined LC and ILD have worse clinical outcomes even when similar treatment modalities are offered.
Impact of [177Lu]Lu-PSMA-617 Radioligand Therapy on Reference Organ Uptake Assessed by [68Ga]Ga-PSMA-11-PET/CT
Authors: Groener Daniel , Wichert Jennifer , Adams Magdalena , Mader Nicolai , Klimek Konrad , Nguyen Ngoc Christina , Baumgarten Justus , Happel Christian , Mandel Philipp , Chun Felix K. H. , Tselis Nikolaos , Grünwald Frank , Sabet Amir
Published: July 2023

This study aims to assess the change in uptake to reference organs, including the liver, parotid and salivary glands after radioligand therapy (RLT) with [177Lu]Lu-PSMA-617 in relation to pretreatment imaging metrics. Eighty-five patients with mCRPC underwent [68Ga]Ga-PSMA-11 PET/CT imaging prior to (pre RLT PET) and after (post RLT PET) a median of 3 (IQR 2-6) RLT cycles with [177Lu]Lu-PSMA-617. PSMA-positive tumor burden was stratified into 4 groups based on modified PROMISE criteria (oligofocal, multifocal, disseminated, diffuse). Uptake (SUVmean, SUVmax) in liver tissue, parotid and submandibular glands was measured. A control group was established with 54 patients who had received two separate PET acquisitions following the same protocol (PET1, PET2) within 12 months for localized or oligofocal prostate cancer without RLT in the interim. Baseline uptake values (SUVmean, SUVmax) in parotid (10.8 ± 3.2, 16.8 ± 5.4) and submandibular glands (11.3 ± 2.8, 18.1 ± 4.7) are 2-fold compared to liver uptake (4.9 ± 1.4, 7.7 ± 2.0), with no significant change between PET 1 and PET 2 in the control group. In the RLT group, increasing tumor burden class is significantly associated with decreasing uptake in the liver (p = 0.013), parotid (p < 0.001) and submandibular glands (p < 0.001); this tumor sink effect by respective tumor burden is widely maintained after RLT (p = 0.011, p < 0.001, p < 0.001). RLT has a significant impact on salivary gland uptake with decreasing values per patient in all groups of disease burden change (up to −30.4% in submandibular glands, p < 0.001), while liver tissue shows rising values in patients with declining tumor burden throughout RLT (+18.6%, p = 0.020). Uptake in liver tissue and salivary glands on [68Ga]Ga-PSMA-11 PET/CT imaging is inversely related to tumor burden prior to and following RLT with [177Lu]Lu-PSMA-617. Per patient, salivary gland uptake is further reduced throughout RLT independently from tumor burden, while changes in liver uptake remain burden-dependent. Liver and salivary gland uptake-derived metrics and segmentation thresholds may thus be of limited value when used as reference for response assessment to RLT.
Surgical Treatment of Carcinomas of the Oral Minor Salivary Glands—Oncological Outcome in Dependence of Tumor Entity and Therapeutic Strategies
Authors: Moratin Julius , Horn Dominik , Semmelmayer Karl , Ristow Oliver , Engel Michael , Hoffmann Jürgen , Bleymehl Moritz , Held Thomas , Zittel Sven , Freudlsperger Christian
Published: July 2023

The aim of this study was to analyze the clinical outcomes of three types of minor salivary gland carcinomas (adenoid-cystic carcinomas (ACC), adeno carcinomas not otherwise specified (AC-NOS), and mucoepidermoid carcinomas (MEC)) after primary surgical therapy. A retrospective cohort study was designed and patients with cancer of the minor oral salivary glands treated in our department in the years 2011 to 2022 were included. Clinicopathological data were evaluated to compare overall survival and progression-free survival between the entities. Eighty-one patients were included. The rates of cervical metastases were 38.9% for ACC, 25% for MEC, and 9.1% for AC-NOS. ACC exhibited significantly higher rates of local and systemic disease recurrence (p = 0.02), and the presence of neck node metastases was confirmed as an independent prognostic factor for progression-free survival (p = 0.014). Treatment success in terms of oncological outcome varied significantly between the different entities and implies different treatment regimens for each tumor entity.
Evaluation of Potential Targets for Fluorescence-Guided Surgery in Pediatric Ewing Sarcoma: A Preclinical Proof-of-Concept Study
Authors: Jeremiasse Bernadette , Rijs Zeger , Angoelal Karieshma R. , Hiemcke-Jiwa Laura S. , de Boed Ella A. , Kuppen Peter J. K. , Sier Cornelis F. M. , van Driel Pieter B. A. A. , van de Sande Michiel A. J. , Wijnen Marc H. W. A. , Rios Anne C. , van der Steeg Alida F. W.
Published: July 2023

Fluorescence-guided surgery (FGS), based on fluorescent tracers binding to tumor-specific biomarkers, could assist surgeons to achieve complete tumor resections. This study evaluated potential biomarkers for FGS in pediatric Ewing sarcoma (ES). Immunohistochemistry (IHC) was performed to assess CD99, CXCR4, CD117, NPY-R-Y1, and IGF-1R expression in ES biopsies and resection specimens. LINGO-1 and GD2 evaluation did not work on the acquired tissue. Based on the immunoreactive scores, anti-CD99 and anti-CD117 were evaluated for binding specificity using flow cytometry and immunofluorescence microscopy. Anti-GD2, a tracer in the developmental phase, was also tested. These three tracers were topically applied to a freshly resected ES tumor and adjacent healthy tissue. IHC demonstrated moderate/strong CD99 and CD117 expression in ES tumor samples, while adjacent healthy tissue had limited expression. Flow cytometry and immunofluorescence microscopy confirmed high CD99 expression, along with low/moderate CD117 and low GD2 expression, in ES cell lines. Topical anti-CD99 and anti-GD2 application on ES tumor showed fluorescence, while anti-CD117 did not show fluorescence for this patient. In conclusion, CD99-targeting tracers hold promise for FGS of ES. CD117 and GD2 tracers could be potential alternatives. The next step towards development of ES-specific FGS tracers could be ex vivo topical application experiments on a large cohort of ES patients.
Metabolites and Immune Response in Tumor Microenvironments
Authors: Cortellino Salvatore , Longo Valter D.
Published: July 2023

The remodeled cancer cell metabolism affects the tumor microenvironment and promotes an immunosuppressive state by changing the levels of macro- and micronutrients and by releasing hormones and cytokines that recruit immunosuppressive immune cells. Novel dietary interventions such as amino acid restriction and periodic fasting mimicking diets can prevent or dampen the formation of an immunosuppressive microenvironment by acting systemically on the release of hormones and growth factors, inhibiting the release of proinflammatory cytokines, and remodeling the tumor vasculature and extracellular matrix. Here, we discuss the latest research on the effects of these therapeutic interventions on immunometabolism and tumor immune response and future scenarios pertaining to how dietary interventions could contribute to cancer therapy.