bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlation between anthropometric measurements and graft size in anterior cruciate ligament reconstruction: a systematic review and meta-analysis
Authors: Salman Loay A. , Moghamis Isam Sami , Hatnouly Ashraf T. , Khatkar Harman , Alebbini Mohanad Mutasem , Al-Ani Abdallah , Hameed Shamsi , AlAteeq Aldosari Mohamed
Published: September 2023

Purpose

This systematic review and meta-analysis aimed to investigate the correlation between anthropometric measurements and graft size in anterior cruciate ligament (ACL) reconstruction.

Methods

A systematic search of Ovid MEDLINE, Embase, and Cochrane Library databases was conducted for observational studies published until March 2023 that reported the relationship between anthropometric data [height, weight, body mass index (BMI), age, gender, thigh length, and circumference] and ACL graft size. Correlation coefficients (COR) and their associated 95% confidence intervals were used as the primary effect size. This review was conducted in line with PRISMA guidelines.

Results

A total of 42 observational studies involving 7110 patients were included, with a mean age of 29.8 years. Statistically significant, moderately positive correlations were found between graft size and height (COR: 0.49; 95% CI: 0.41–0.57; p-value: < 0.001), weight (COR: 0.38; 95% CI: 0.31–0.44; p-value: < 0.001), thigh circumference (COR: 0.40; 95% CI: 0.19–0.58; p-value: < 0.001), and thigh length (COR: 0.35; 95% CI: 0.18–0.50; p-value: < 0.001). However, age and gender were insignificantly correlated with graft size (p-value: NS). A subanalysis based on graft type showed a significant positive correlation between height and graft diameter, which was more significant in the peroneus tendon than in hamstring grafts (COR: 0.76 vs. 0.45; p-value: 0.020).

Conclusion

This study demonstrated a moderate positive correlation between anthropometric measurements (height, weight, thigh circumference, and length) and ACL graft size, along with a weak positive correlation with BMI. Age and gender showed no significant correlation. These findings support the predictability and selection of ACL graft size based on pre-operative patient anthropometric data.

Level of evidence

Level of Evidence: IV.

PROSPERO registration number: CRD42023416044.
Synergistic effects of low - level magnesium and chromium doping on the electrochemical performance of LiNiO2 cathodes
Authors: Laine Petteri , Välikangas Juho , Kauppinen Toni , Hu Tao , Wang Shubo , King Graham , Singh Harishchandra , Tynjälä Pekka , Lassi Ulla
Published: September 2023

LiNiO2 cathode materials with magnesium and chromium doping were prepared using a simple low - cost and efficient co - precipitation and lithiation procedure. During this procedure, both magnesium and chromium form a concentrated core particle, unto which nickel hydroxide precipitates. During lithiation, the elements in question will redistribute themselves and form a homogenous mixture. Magnesium - containing materials exhibit an excellent electrochemical performance, due to phase stabilizing effects, while for chromium - containing materials, performance remains poor. Rietveld refinement reveals that there is a possible upper limit for Mg doping (~ 2.5 mol %) as a pilar dopant. Washing of the lithiated materials was explored, and it is proposed that this can improve capacity retention in prolonged cycling. However, the inevitable loss of lithium from the surface layer remains a challenge. Two sources for the chromium facilitated capacity decay are proposed, both owing to the highly irreversible redox reaction of hexavalent chromium possibly blocking lithium pathways.
Tumor size, treatment patterns, and survival in neuro-oncology patients before and during the COVID-19 pandemic
Authors: Karamani Lydia , McLean Aaron Lawson , Kamp Marcel A. , Mayer Thomas E. , Müller Wolf , Dinc Nazife , Senft Christian
Published: September 2023

The COVID-19 pandemic has disrupted healthcare delivery worldwide, leading to significant delays in cancer diagnosis and treatment. This study aimed to investigate the impact of the pandemic on the diagnosis and treatment of malignant brain tumors, specifically glioblastoma (GBM) and cerebral metastasis (CM), in a specialized neuro-oncology center. We analyzed data from 236 patients diagnosed with previously unknown malignant brain tumors between January 2018 and December 2021. Patients were classified into two groups: pre-COVID (January 2018 to December 2019) and COVID (January 2020 to December 2021). Tumor volumes were compared between the two groups and factors affecting tumor volumes were studied. Of 236 patients diagnosed with previously unknown malignant brain tumors, 114 were in the pre-COVID group and 122 were in the COVID group. Median tumor volumes at first diagnosis were significantly larger in the COVID group compared to the pre-COVID group (21.7 vs 15.7 cm3; p < 0.05). The survival times for the overall cohort and the GBM and CM subgroups did not differ significantly between the pre-COVID and COVID periods. Delays in diagnosis and treatment during the COVID-19 pandemic led to larger tumor volumes at diagnosis for patients with malignant brain tumors. However, these larger tumors did not result in worse survival outcomes. This counterintuitive finding highlights the crucial role of specialized neuro-oncological centers in mitigating the potential negative impact of delayed treatment and emphasizes the need for continued access to specialized care during times of crisis.
Global Connections and Connected Communities in the African Past: Stories from Cowrie Shells
Authors: Haour Anne , Moffett Abigail
Published: September 2023

Through the stories of four people who carried or traded cowrie shells, this article examines the connections between various parts of the world from a thousand years ago to the present. These connections spanned great distances, linking communities in West Africa and the Indian Ocean islands of the Maldives, and they bring to light the vast land and sea links that connected different regions of the African continent to the wider world in this period. We use cowrie shells to explore how objects participate in creating social relations, shaping senses of self and identity. When viewed in relation to the theme of connections, this offers a springboard for thinking about how things and their biographies fit within our lives today.
Accumulation and within-mushroom distribution of elements in red cracking bolete (Xerocomellus chrysenteron) collected over the extended period from compositionally contrasting substrates
Authors: Andronikov Alexandre V. , Andronikova Irina E. , Sebek Ondrej , Martinkova Eva , Stepanova Marketa
Published: September 2023

We conducted a study of elemental compositions of Xerocomellus chrysenteron samples accompanied by samples of related substrate soils. All samples were collected during the harvesting seasons 2021 and 2022 from three forested sites almost unpolluted by recent human activities and underlain by contrasting bedrock (granite, amphibolite, and serpentinite). Elements such as Ag, Cd, K, P, Rb, S, Se, and Zn were the main elements enriched in the mushroom’s fruiting bodies relative to the substrate. Concentrations of most elements in mushrooms were not site-dependent, with only Ag, As, Rb, and Se concentrations significantly depending on the bedrock composition. Some elements analyzed in mushrooms displayed temporal features, but such features were not systematic and varied for each element. Most analyzed elements were distributed unevenly within the mushroom’s fruiting bodies, with apical parts generally enriched in mobile elements. Mushrooms influenced concentrations of Ag, Cd, K, and Rb and a few other elements in the substrate via uptake, but such influence was very limited and can be responsible for only 2.5–11.5% of total depletion of the affected substrate in the named elements.
Dense subgraphs induced by edge labels
Authors: Kumpulainen Iiro , Tatti Nikolaj
Published: September 2023

Finding densely connected groups of nodes in networks is a widely-used tool for analysis in graph mining. A popular choice for finding such groups is to find subgraphs with a high average degree. While useful, interpreting such subgraphs may be difficult. On the other hand, many real-world networks have additional information, and we are specifically interested in networks with labels on edges. In this paper, we study finding sets of labels that induce dense subgraphs. We consider two notions of density: average degree and the number of edges minus the number of nodes weighted by a parameter $$\alpha$$
α
. There are many ways to induce a subgraph from a set of labels, and we study two cases: First, we study conjunctive-induced dense subgraphs, where the subgraph edges need to have all labels. Secondly, we study disjunctive-induced dense subgraphs, where the subgraph edges need to have at least one label. We show that both problems are NP-hard. Because of the hardness, we resort to greedy heuristics. We show that we can implement the greedy search efficiently: the respective running times for finding conjunctive-induced and disjunctive-induced dense subgraphs are in $$\mathcal {O} \mathopen {}\left( p \log k\right)$$

O

p
log
k

and $$\mathcal {O} \mathopen {}\left( p \log ^2 k\right)$$

O

p

log
2

k

, where p is the number of edge-label pairs and k is the number of labels. Our experimental evaluation demonstrates that we can find the ground truth in synthetic graphs and that we can find interpretable subgraphs from real-world networks.
Efficient generator of mathematical expressions for symbolic regression
Authors: Mežnar Sebastian , Džeroski Sašo , Todorovski Ljupčo
Published: September 2023

We propose an approach to symbolic regression based on a novel variational autoencoder for generating hierarchical structures, HVAE. It combines simple atomic units with shared weights to recursively encode and decode the individual nodes in the hierarchy. Encoding is performed bottom-up and decoding top-down. We empirically show that HVAE can be trained efficiently with small corpora of mathematical expressions and can accurately encode expressions into a smooth low-dimensional latent space. The latter can be efficiently explored with various optimization methods to address the task of symbolic regression. Indeed, random search through the latent space of HVAE performs better than random search through expressions generated by manually crafted probabilistic grammars for mathematical expressions. Finally, EDHiE system for symbolic regression, which applies an evolutionary algorithm to the latent space of HVAE, reconstructs equations from a standard symbolic regression benchmark better than a state-of-the-art system based on a similar combination of deep learning and evolutionary algorithms.
Non-invasive phenotyping for water and nitrogen uptake by deep roots explored using machine learning
Authors: Changdar Satyasaran , Popovic Olga , Wacker Tomke Susanne , Markussen Bo , Dam Erik Bjørnager , Thorup-Kristensen Kristian
Published: September 2023

Background and aims

Root distribution over the soil profile is important for crop resource uptake. Using machine learning (ML), this study investigated whether measured square root of planar root length density (Sqrt_pRLD) at different soil depths were related to uptake of isotope tracer (15N) and drought stress indicator (13C) in wheat, to reveal root function.

Methods

In the RadiMax semi-field root-screening facility 95 winter wheat genotypes were phenotyped for root growth in 2018 and 120 genotypes in 2019. Using the minirhizotron technique, root images were acquired across a depth range from 80 to 250 cm in May, June, and July and RL was extracted using a convolutional neural network. We developed ML models to explore whether the Sqrt_pRLD estimates at different soil depths were predictive of the uptake of deep soil nitrogen - using deep placement of 15N tracer as well as natural abundance of 13C isotope. We analyzed the correlations to tracer levels to both a parametrized root depth estimation and an ML approach. We further analyzed the genotypic effects on root function using mediation analysis.

Results

Both parametrized and ML models demonstrated clear correlations between Sqrt_pRLD distribution and resource uptake. Further, both models demonstrated that deep roots at approx. 150 to 170 cm depth were most important for explaining the plant content of 15N and 13C isotopes. The correlations were higher in 2018.

Conclusions

The results demonstrated that, parametrized models and ML-based analysis provided complementary insight into the importance of deep rooting for water and nitrogen uptake.
Exploring and Measuring Quality of Life Determinants of Wage Workers in Egypt: A Structural Equation Modelling Approach
Authors: Zeini Nahed T. , Okasha Ahmed E. , Soliman Amal S.
Published: September 2023

This paper aims to identify the major significant dimensions that contribute to the overall quality of life (QOL) of wage workers in Egypt. As the QOL is a complex, multidimensional, and interdisciplinary concept, forty-seven indicators under five domains were chosen to investigate the QOL determinants of wage workers in Egypt, namely job characteristics, job satisfaction, ICT access, gender equality and women empowerment, and neighborhood services and utilities. Using data from the 2018 wave of the Egypt Labor Market Panel Survey, the paper employed structural equation modelling (SEM) approach to investigate the impact of proposed dimensions on the overall QOL. In addition, multi-group SEM analysis was implemented to measure how people differ in the way they assess their QOL on the basis of various moderating variables such as the geographical region of residence, age group, and years of schooling. The findings showed the significant impact of the chosen dimensions on the overall QOL. Moreover, the multi-group models showed a significant variation among compared groups, in which the weights of dimensions vary due to the differences in socio-cultural characteristics and the surrounding environment, confirming the complexity of such a concept. As people usually differ in the way they assess their QOL, which is affected by their characteristics and priorities.
Does Renal Denervation a Reasonable Treatment Option in Hemodialysis-Dependent Patient with Resistant Hypertension? A Narrative Review
Authors: Mazza Alberto , Dell’Avvocata Fabio , Torin Gioia , Bulighin Francesca , Battaglia Yuri , Fiorini Fulvio
Published: September 2023

Purpose of Review

This narrative review aims to assess the pathophysiology, diagnosis, and treatment of resistant hypertension (RH) in end-stage kidney disease (ESKD) patients on dialysis, with a specific focus on the effect of renal denervation (RDN) on short-term and long-term blood pressure (BP) control. Additionally, we share our experience with the use of RDN in an amyloidotic patient undergoing hemodialysis with RH.

Recent Findings

High BP, an important modifiable cardiovascular risk factor, is often observed in patients in ESKD, despite the administration of multiple antihypertensive medications. However, in clinical practice, it remains challenging to identify RH patients on dialysis treatment because of the absence of specific definition for RH in this context. Moreover, the use of invasive approaches, such as RDN, to treat RH is limited by the exclusion of patients with reduced renal function (eGFR < 45 mL/min/1.73 m3) in the clinical trials. Nevertheless, recent studies have reported encouraging results regarding the effectiveness of RDN in stage 3 and 4 chronic kidney disease (CKD) and ESKD patients on dialysis, with reductions in BP of nearly up to 10 mmhg.

Although multiple underlying pathophysiological mechanisms contribute to RH, the overactivation of the sympathetic nervous system in ESKD patients on dialysis plays a crucial role. The diagnosis of RH requires both confirmation of adherence to antihypertensive therapy and the presence of uncontrolled BP values by ambulatory BP monitoring or home BP monitoring. Treatment involves a combination of nonpharmacological approaches (such as dry weight reduction, sodium restriction, dialysate sodium concentration reduction, and exercise) and pharmacological treatments. A promising approach for managing of RH is based on catheter-based RDN, through radiofrequency, ultrasound, or alcohol infusion, directly targeting on sympathetic overactivity.
Fluctuating asymmetry in third molar agenesis as an aid to estimate socioeconomic status
Authors: Dinis Ana Rita , Teixeira Alexandra , Pérez-Mongiovi Daniel , Caldas Inês Morais
Published: September 2023

Traditionally, dental identification techniques are used to establish identity or assist in reconstructing an individual's biological profile. However, other aspects of identity, namely socioeconomic status (SES), can be estimated through teeth. This work aims to evaluate the influence of SES on third molar agenesis in a Portuguese population. X-rays from 448 subjects (223 belonging to a high and 225 to a low socioeconomic status) were assessed and demographic data (age, sex) and dental history were registered. Frequencies and associations between the variables were analyzed using the chi-square test. For each group, differences between third molar agenesis were studied using the Wilcoxon test. The significance level was 5%. X-rays displaying at least one agenesis were more common in females (in both SES groups). Differences between socioeconomic status were found in female subjects' upper right and lower left third molars, with a higher frequency of agenesis in the lower SES group. Agenesis of lower third molars displayed fluctuant asymmetry in both groups, whereas agenesis of upper third molars was also present in the lower SES group. These results suggest that socioeconomic status can affect third molar agenesis prevalence, and fluctuant asymmetry seems more prevalent in the lower SES, as it affects all third molars.
Honor in the Wild
Authors: Windzio Michael , Baier Dirk
Published: September 2023

“Culture of honor” means that individuals deter others by signaling their commitment to violent retaliation. We develop a multilevel explanation of cross-level interdependence of honor and violence. According to our concept of system-level honor, a social system is loaded with deterrence signaling if culture of honor is highly prevalent in the system. In line with the Smith and Price (1973, in Nature,https://www.nature.com/articles/246015a0) model, we argue that high system-level honor discourages Prober-Retaliator behavior: some individuals might tend to challenge others they assume to be inferior to increase their own reputation. Both individual culture of honor and system-level honor contribute to an increase in violence (H1; H2). However, as system-level honor and deterrence become more prevalent, the impact of individual honor diminishes because engaging in violent behavior becomes increasingly expensive within such a system (H3). As a second contextual effect, inequality in culture of honor should therefore increase violent behavior because it encourages Prober-Retaliator behavior (H4). We analyze the effect of culture of honor on school violence among 15-year-old adolescents. Disentangling the micro- and context-level effects of culture of honor on violent behavior in a multilevel analysis framework allows the estimation of a cross-level interaction using a large data set from more than 25,000 adolescents in more than 1,300 schoolroom contexts. Results are in line with our H3, but not with H4. Model-based predictions show that the deterrent effect must be unrealistically high to generate an equilibrium of average violence.
Noninvasive Electrical Mapping Compared with the Paced QRS Complex for Optimizing CRT Programmed Settings and Predicting Multidimensional Response
Authors: Morales Frances L. , Bivona Derek J. , Abdi Mohamad , Malhotra Rohit , Monfredi Oliver , Darby Andrew , Mason Pamela K. , Mangrum J. Michael , Mazimba Sula , Stadler Robert W. , Epstein Frederick H. , Bilchick Kenneth C. , Oomen Pim J. A.
Published: September 2023

The aim was to test the hypothesis that left ventricular (LV) and right ventricular (RV) activation from body surface electrical mapping (CardioInsight 252-electrode vest, Medtronic) identifies optimal cardiac resynchronization therapy (CRT) pacing strategies and outcomes in 30 patients. The LV80, RV80, and BIV80 were defined as the times to 80% LV, RV, or biventricular electrical activation. Smaller differences in the LV80 and RV80 (|LV80-RV80|) with synchronized LV pacing predicted better LV function post-CRT (p = 0.0004) than the LV-paced QRS duration (p = 0.32). Likewise, a lower RV80 was associated with a better pre-CRT RV ejection fraction by CMR (r =  − 0.40, p = 0.04) and predicted post-CRT improvements in myocardial oxygen uptake (p = 0.01) better than the biventricular-paced QRS (p = 0.38), while a lower LV80 with BIV pacing predicted lower post-CRT B-type natriuretic peptide (BNP) (p = 0.02). RV pacing improved LV function with smaller |LV80-RV80| (p = 0.009). In conclusion, 3-D electrical mapping predicted favorable post-CRT outcomes and informed effective pacing strategies.

Graphical Abstract
Design and Development of a Technological Platform Based on a Sensorized Social Robot for Supporting Older Adults and Caregivers: GUARDIAN Ecosystem
Authors: Ciuffreda Ilaria , Amabili Giulio , Casaccia Sara , Benadduci Marco , Margaritini Arianna , Maranesi Elvira , Marconi Fabrizio , De Masi Alexander , Alberts Janna , de Koning Judith , Cuijpers Raymond , Revel Gian Marco , Nap Henk Herman , Vastenburg Martijn , Naveira Alexandra Villaverde , Bevilacqua Roberta
Published: September 2023

In this paper, a new ecosystem to support older adults and their caregivers in an indoor living environment is proposed. The GUARDIAN ecosystem is designed to address the different needs of end users in different countries. The ecosystem consists of a socially assistive robot (SAR), including sensors, and two mobile applications (one for caregivers and one for the older user). Starting from a user-centred and value-sensitive co-design approach, three key user requirements have been identified: monitoring, reminding, and social companionship. User requirements were translated into technical requirements to develop a flexible system architecture. Usability tests were performed to verify the satisfaction level about the GUARDIAN concept. User tests were carried out in three different countries involving 13 older adults, 14 informal carers and 15 formal carers showing that the proposed ecosystem satisfies the user requirements. These results confirm the feasibility of the application of the GUARDIAN ecosystem in living indoor environments.
Re-considering the Role of Sleep Hygiene Behaviours in Sleep: Associations Between Sleep Hygiene, Perceptions and Sleep
Authors: McAlpine Thomas , Mullan Barbara , Clarke Patrick J. F.
Published: September 2023

Background

Sleep hygiene behaviours are a suggested set of behaviours people can engage in to improve sleep. However, there are numerous issues relating to the measurement of sleep hygiene, primarily, the lack of consensus as to which behaviours impact sleep and should therefore be included in scales.

Method

Cross-sectional correlational methods were used to assess the association between sleep quality, a highly inclusive range of sleep hygiene behaviours, and individual perceptions of those behaviours in a non-clinical sample of 300 participants.

Results

Of the 35 sleep hygiene behaviours assessed, 18 were independently associated with sleep quality. Post-hoc factor analysis revealed that behaviours clustered together across four factors. A ‘routine’ factor included behaviours such as going to bed and waking up at the same time each night, and were important predictors of sleep quality, as were behaviours belonging to the ‘perseverative cognition’ and ‘negative emotionality’ factor. Other behaviours related to physiological processes like exposure to sunlight during the day and going to bed hungry were also significantly associated with sleep. Negative perceptions moderated the relationship between daytime exposure to sunlight and sleep.

Conclusions

Although certain behaviours were significantly related to sleep, almost half were not, supporting the need to examine the association between sleep and behaviours used for sleep hygiene recommendations more critically. Reframing sleep hygiene recommendations into a condensed set of shared underlying mechanisms may be of benefit for the development of sleep hygiene scales and interventions in non-clinical populations.
Use of light-weight foaming polylactic acid as a lung-equivalent material in 3D printed phantoms
Authors: Crowe Scott , Maxwell Sarah , Brar Harsimran , Yu Liting , Kairn Tanya
Published: September 2023

The 3D printing of lung-equivalent phantoms using conventional polylactic acid (PLA) filaments requires the use of low in-fill printing densities, which can produce substantial density heterogeneities from the air gaps within the resulting prints. Light-weight foaming PLA filaments produce microscopic air bubbles when heated to 3D printing temperatures. In this study, the expansion of foaming PLA filament was characterised for two 3D printers with different nozzle diameters, in order to optimise the printing flow rates required to achieve a low density print when printed at 100% in-fill printing density, without noticeable internal air gaps. Effective densities as low as 0.28 g cm− 3 were shown to be achievable with only microscopic air gaps. Light-weight foaming PLA filaments are a cost-effective method for achieving homogeneous lung-equivalency in 3D printed phantoms for use in radiotherapy imaging and dosimetry, featuring smaller air gaps than required to achieve low densities with conventional PLA filaments.
Advantage of ostarine over raloxifene and their combined treatments for muscle of estrogen-deficient rats
Authors: Roch P. J. , Noisser L. , Böker K. O. , Hoffmann D. B. , Schilling A. F. , Sehmisch S. , Komrakova M.
Published: September 2023

Purpose

Selective androgen (ostarine, OST) and estrogen (raloxifene, RAL) receptor modulators with improved tissue selectivity have been developed as alternatives to hormone replacement therapy. We investigated the combined effects of OST and RAL on muscle tissue in an estrogen-deficient rat model of postmenopausal conditions.

Methods

Three-month-old Sprague Dawley rats were divided into groups: (1) untreated non-ovariectomized rats (Non-OVX), (2) untreated ovariectomized rats (OVX), (3) OVX rats treated with OST, (4) OVX rats treated with RAL, (5) OVX rats treated with OST and RAL. Both compounds were administered in the diet. The average dose received was 0.6 ± 0.1 mg for OST and 11.1 ± 1.2 mg for RAL per kg body weight/day. After thirteen weeks, rat activity, muscle weight, structure, gene expression, and serum markers were analyzed.

Results

OST increased muscle weight, capillary ratio, insulin-like growth factor 1 (Igf-1) expression, serum phosphorus, uterine weight. RAL decreased muscle weight, capillary ratio, food intake, serum calcium and increased Igf-1 and Myostatin expression, serum follicle stimulating hormone (FSH). OST + RAL increased muscle nucleus ratio, uterine weight, serum phosphorus, FSH and luteinizing hormone and decreased body and muscle weight, serum calcium. Neither treatment changed muscle fiber size. OVX increased body and muscle weight, decreased uterine weight, serum calcium and magnesium.

Conclusion

OST had beneficial effects on muscle in OVX rats. Side effects of OST on the uterus and serum electrolytes should be considered before using it for therapeutic purposes. RAL and RAL + OST had less effect on muscle and showed endocrinological side effects on pituitary–gonadal axis.
Medical Students’ Opinion of Their Learning Process
Authors: Montané Eva , Vilaplana Cristina , Riera Joan , Pujol Marina , Méndez Maria , Mas Albert , Vara Angel , Parés David
Published: September 2023

Introduction

The opinion of students is of utmost importance to identify areas of improvement in undergraduate studies. Medical schools would use this information to plan actions to ensure that the students achieve the necessary medical knowledge. The aim of this study was to analyse the opinion of medical students about their learning process and to analyse the influence of their experience according to their year of medical degree.

Methods

A questionnaire including 21 items, divided into four sections (motivation, theory lectures, hospital internships, and research) and two overall questions, was distributed among eligible 246 students. Each item was scored from 1 (strongly disagree) to 5 (strongly agree). The opinions of intermediate-year students of medical degree (3rd and 4th) were compared to late-year students (5th and 6th).

Results

A total of 148 students answered the questionnaire (60.2% response rate). The mean scores for overall student motivation and teaching quality were 6.15 and 7.10, respectively. The student–teacher interaction and new learning technological tools were considered important for student motivation. The only differences found between the two groups of students were that late-year students wished to become part of a medical team and to learn writing scientific papers more than the intermediate-year students.

Conclusions

This questionnaire revealed that the year of career had little influence on the medical students’ opinion on their learning process during their undergraduate studies. Late-year students rated highest on being more interested in being part of a medical team and their knowledge on writing scientific articles. The use of new technologies and the student–teacher interaction is key to motivate students.
Numerical investigation on blast-induced rock fragmentation with different stemming structures
Authors: Li Xudong , Liu Kewei , Sha Yanyan , Yang Jiacai , Hong Zhixian
Published: September 2023

Stemming is one of the main concerns in blast of rock engineering due to its impact on explosion energy consumption and rock excavation performance. In this study, blast-induced rock fragmentation under different stemming conditions is numerically studied using combined numerical modelling and image processing. After careful determination the parameters of constitutive material models, the developed numerical model in LS-DYNA is verified based on the blast testing results including rock fracturing and fragment size distribution (FSD). The calibrated constitutive models are then used to model the pressure variation and rock disintegration produced by blasting with different stemming structures. The size data of simulated rock fragmentation are obtained by image-processing the cut surfaces of the numerical model with the program ImageJ, and the blast-created rock FSD is characterized using a three-parameter generalized extreme value function. The effects of the combination of explosive, air/sand deck and stemming on blast-induced rock fragmentation are quantitatively analysed, considering various stemming modes, stemming lengths and air/sand deck lengths. The results show that the blast-created fragment size decreases with an increase in stemming length, a decreasing in air/sand deck length, replacement of top stemming (stemming at borehole collar with air deck) with bottom stemming (stemming directly contact explosive) and alteration of air deck to sand deck, while the FSD range exhibits the opposite tendency. Bottom stemming is recommended for practical blasting due to its efficiency in rock fragmentation and robustness with respect to stemming length.
The use of N-of-1 trials to generate real-world evidence for optimal treatment of individuals and populations
Authors: Selker Harry P. , Dulko Dorothy , Greenblatt David J. , Palm Marisha , Trinquart Ludovic
Published: September 2023

Introduction:

Ideally, real-world data (RWD) collected to generate real-world evidence (RWE) should lead to impact on the care and health of real-world patients. Deriving from care in which clinicians and patients try various treatments to inform therapeutic decisions, N-of-1 trials bring scientific methods to real-world practice.

Methods:

These single-patient crossover trials generate RWD and RWE by giving individual patients various treatments in a double-blinded way in sequential periods to determine the most effective treatment for a given patient.

Results:

This approach is most often used for patients with chronic, relatively stable conditions that provide the opportunity to make comparisons over multiple treatment periods, termed Type 1 N-of-1 trials. These are most helpful when there is heterogeneity of treatment effects among patients and no a priori best option. N-of-1 trials also can be done for patients with rare diseases, potentially testing only one treatment, to generate evidence for personalized treatment decisions, designated as Type 2 N-of-1 trials. With both types, in addition to informing individual’s treatments, when uniform protocols are used for multiple patients with the same condition, the data collected in the individual N-of-1 trials can be aggregated to provide RWD/RWE to inform more general use of the treatments. Thereby, N-of-1 trials can provide RWE for the care of individuals and for populations.

Conclusions:

To fulfill this potential, we believe N-of-1 trials should be built into our current healthcare ecosystem. To this end, we are building the needed infrastructure and engaging the stakeholders who should receive value from this approach.
Efficacy of vitamin D2 in maintaining serum total vitamin D concentrations and bone mineralisation in adult dogs fed a plant-based (vegan) diet in a 3-month randomised trial
Authors: Dodd Sarah A. S. , Adolphe Jennifer , Dewey Cate , Khosa Deep , Abood Sarah K. , Verbrugghe Adronie
Published: September 2023

Dogs are considered omnivores based on their evolution consuming diets including animal tissue. Few feeding trials evaluating the nutritional suitability of exclusively plant-based (vegan) diets in dogs have been published, and the efficacy of vitamin D2 in maintaining canine serum vitamin D levels has not been clearly determined. A blinded dietary trial included sixty-one healthy desexed adult dogs: thirty-one fed an experimental extruded vegan diet (PLANT) and thirty fed a commercial extruded meat-based diet (MEAT) for 3 months. Dogs were screened via veterinary examination and routine laboratory analyses prior to enrolment, at baseline and exit timepoints. Body composition was measured by dual-energy X-ray absorptiometry and blood was collected for vitamin D profiling. All dogs maintained health parameters, body weight and composition throughout the study. Dogs maintained on PLANT demonstrated a significant reduction in platelet count, creatinine, blood urea nitrogen and cholesterol, though values remained within normal reference ranges. Dogs fed PLANT also demonstrated a shift from vitamin D3 to vitamin D2 metabolites, though total vitamin D analogue levels were unchanged, with the exception of 24,25-dihydroxyvitamin D. Bone mineral content and density did not differ from baseline values. Health status was maintained in dogs fed PLANT and vitamin D2 appeared efficacious in maintaining serum total vitamin D concentrations and bone mineralisation. Findings support the hypothesis that PLANT was comparable to MEAT for maintenance of healthy adult dogs for at least 3 months and identified areas where further research is warranted to elucidate the potential risks and benefits of plant-based (vegan) diets.
Trajectories of crop–livestock integration in the context of specialization in Northwest Vietnam
Authors: Le Trouher Alice , Moulin Charles-Henri , Huyen Le Thi Thanh , Blanchard Mélanie
Published: September 2023

Mixed crop–livestock systems, the world's most widespread farming systems, promote farm resilience through diversification and allow for crop–livestock integration (CLI). Intensification and specialization challenge these systems. In Northwest Vietnam, the standard farm model is based on mixed crop–livestock family farms but is shifting towards more specialized farming systems. The aim of the current study was to identify the new balance between livestock and crops on farms in Northwest Vietnam and to examine the effects of specialization on CLI practices and production system intensification by identifying current CLI practices and performing a retrospective analysis of changes in these practices. One hundred farms were surveyed and 24 interviews on farm trajectories were conducted in Dien Bien district (Dien Bien province) between January and April 2022. Based on the level of CLI and farm diversification, seven types of farms were identified and classified into three categories: (B) mixed farms, (A) farms specializing in livestock and (C) farms specializing in crops. The study of farm trajectories revealed three main changes: the conversion of mixed crop–livestock farms into more specialized crop systems, a change from mixed crop–livestock to more specialized family livestock farms and a change in the management of large ruminant herds and their feed system from free grazing to forage-fed systems. Understanding these changes will help identify drivers and potential constraints to the development of new practices for the integration of crop and livestock farming.
A first genome survey sequencing of alvinocaridid shrimp Shinkaicaris leurokolos in deep-sea hydrothermal vent environment
Authors: Wang Aiyang , Cheng Jiao , Xin Qian , Sha Zhongli , Hui Min
Published: September 2023

The alvinocaridid shrimp Shinkaicaris leurokolos Kikuchi and Hashimoto, 2000, is an evolutionarily important deep-sea species in hydrothermal vents of north-western Pacific. A genome survey of S. leurokolos was carried out in order to provide a foundation for its whole-genome sequencing. A total of 599 Gb high-quality sequence data were obtained in the study, representing approximately 118× coverage of the S. leurokolos genome. According to the 17-mer distribution frequency, the estimated genome size was 5.08 Gb, and its heterozygosity ratio and percentage of repeated sequences were 2.85 and 87.03%, respectively, showing a complex genome. The final scaffold assembly accounted for a total size of 9.53 Gb (32,796,062 scaffolds, N50 = 597 bp). Repetitive elements nearly constituted 45% of the nuclear genome, among which the most ubiquitous were long interspersed nuclear elements, DNA transposons and long-terminal repeat elements. A total of 12,121,553 genomic simple sequence repeats were identified, with the most frequent repeat motif being di-nucleotide (70.27%), followed by tri-nucleotide and tetra-nucleotide. From the genome survey sequences, the mitochondrial genome of S. leurokolos was also constructed and 71 single nucleotide polymorphisms were identified by comparison with previous published reference. This is the first report of de novo whole-genome sequencing and assembly of S. leurokolos. These newly developed genomic data contribute to a better understanding of genomic characteristics of shrimps from deep-sea chemosynthetic ecosystems, and provides valuable resources for further molecular marker development.
On the origins and emergence of the Qaŋlï Turks
Authors: Erkoç Hayrettin İhsan
Published: September 2023

The Qaŋlï (Qangli) Turks were a numerous people, active in Eurasia in the twelfth to thirteenth centuries, but their ultimate origins remain a matter of debate. Often considered by modern scholars to be a part of the Kipchaks (Cumans), others have different opinions. One of these links them to cart-riding early medieval Turkic tribes called Tägräks, known in Chinese sources as Tiele 鐵勒, among other forms. This article examines the earliest possible (eighth-century) references to the Qaŋlïs in the historical sources, and points to the potential links between them and various tribes seen among Turko-Mongol groupings of the ninth to tenth centuries mentioned in the Chinese sources, such as the Black Carts (Heichezi 黑車子). Another aspect that this article focuses on is how both historical and mythological texts of the Mongol period show the Qaŋlïs to be a people distinct from the Kipchaks. Ultimately, this study, which is based on both historical sources and modern research, proposes to locate the origins of the Qaŋlï Turks among Tägräk tribes.
Cultural Unconscious: A Theory of Cultural Criticism
Authors: Gu Ming Dong
Published: September 2023

‘Cultural unconscious’ is a vague term in literary and cultural studies. It has not yet been systematically examined from the conceptual standpoint. As a concept, it is not a simple idea that combines ‘culture’ and ‘unconscious’, but refers to the mechanism of cultural psychology and epistemology structured on the interaction of history, psychology, discourse, ideology and other factors. By investigating how culture and the unconscious work together to form a concept from the integrated approach of psychoanalysis and semiotics, this article aims to turn a vague idea into a clearly defined theory of criticism with practical applicability for cultural studies. After a conception of its logic and mechanism in terms of Freud’s unconscious, Lacan’s renovation, Peirce’s semiosis, and Barthes’s semiology, the article applies the new theory to the analysis of a literary text to see how it may not only help reveal deep dimensions and mechanism of cultural consciousness but also has the potential of becoming a theory of cultural criticism.
Supermarket Transaction Records In Dietary Evaluation: the STRIDE study: validation against self-reported dietary intake
Authors: Jenneson Victoria , Greenwood Darren C , Clarke Graham P , Rains Tim , Tempest Bethan , Shute Becky , Morris Michelle A
Published: September 2023

Objective:

Scalable methods are required for population dietary monitoring. The Supermarket Transaction Records In Dietary Evaluation (STRIDE) study compares dietary estimates from supermarket transactions with an online FFQ.

Design:

Participants were recruited in four waves, accounting for seasonal dietary variation. Purchases were collected for 1 year during and 1 year prior to the study. Bland–Altman agreement and limits of agreement (LoA) were calculated for energy, sugar, fat, saturated fat, protein and sodium (absolute and relative).

Setting:

This study was partnered with a large UK retailer.

Participants:

Totally, 1788 participants from four UK regions were recruited from the retailer’s loyalty card customer database, according to breadth and frequency of purchases. Six hundred and eighty-six participants were included for analysis.

Results:

The analysis sample were mostly female (72 %), with a mean age of 56 years (sd 13). The ratio of purchases to intakes varied depending on amounts purchased and consumed; purchases under-estimated intakes for smaller amounts on average, but over-estimated for larger amounts. For absolute measures, the LoA across households were wide, for example, for energy intake of 2000 kcal, purchases could under- or over-estimate intake by a factor of 5; values could be between 400 kcal and 10000 kcal. LoA for relative (energy-adjusted) estimates were smaller, for example, for 14 % of total energy from saturated fat, purchase estimates may be between 7 % and 27 %.

Conclusions:

Agreement between purchases and intake was highly variable, strongest for smaller loyal households and for relative values. For some customers, relative nutrient purchases are a reasonable proxy for dietary composition indicating utility in population-level dietary research.
Clinical and cognitive effects of external trigeminal nerve stimulation (eTNS) in neurological and psychiatric disorders: a systematic review and meta-analysis
Authors: Westwood Samuel J. , Conti Aldo Alberto , Tang Wanjie , Xue Shuang , Cortese Samuele , Rubia Katya
Published: September 2023

This pre-registered (CRD42022322038) systematic review and meta-analysis investigated clinical and cognitive outcomes of external trigeminal nerve stimulation (eTNS) in neurological and psychiatric disorders. PubMed, OVID, Web of Science, Chinese National Knowledge Infrastructure, Wanfang, and VIP database for Chinese technical periodicals were searched (until 16/03/2022) to identify trials investigating cognitive and clinical outcomes of eTNS in neurological or psychiatric disorders. The Cochrane Risk of Bias 2.0 tool assessed randomized controlled trials (RCTs), while the Risk of Bias of Non-Randomized Studies (ROBINS-I) assessed single-arm trials. Fifty-five peer-reviewed articles based on 48 (27 RCTs; 21 single-arm) trials were included, of which 12 trials were meta-analyzed (N participants = 1048; of which ~3% ADHD, ~3% Epilepsy, ~94% Migraine; age range: 10–49 years). The meta-analyses showed that migraine pain intensity (K trials = 4, N = 485; SMD = 1.03, 95% CI[0.84–1.23]) and quality of life (K = 2, N = 304; SMD = 1.88, 95% CI[1.22–2.53]) significantly improved with eTNS combined with anti-migraine medication. Dimensional measures of depression improved with eTNS across 3 different disorders (K = 3, N = 111; SMD = 0.45, 95% CI[0.01–0.88]). eTNS was well-tolerated, with a good adverse event profile across disorders. eTNS is potentially clinically relevant in other disorders, but well-blinded, adequately powered RCTs must replicate findings and support optimal dosage guidance.
Lysine methyltransferase SMYD2 inhibits antiviral innate immunity by promoting IRF3 dephosphorylation
Authors: Wu Jiacheng , Hu Ye , Song Jiaying , Xu Jia , Zhang Qian , Chai Yangyang , Wang Xin , Wang Bingjing , Zhao Yong , Cao Xuetao , Xu Xiaoqing
Published: September 2023

Abstracts

Phosphorylation of IRF3 is critical to induce type I interferon (IFN-I) production in antiviral innate response. Here we report that lysine methyltransferase SMYD2 inhibits the expressions of IFN-I and proinflammatory cytokines in macrophages upon viral infections. The Smyd2-deficient mice are more resistant to viral infection by producing more IFN-I and proinflammatory cytokines. Mechanistically, SMYD2 inhibits IRF3 phosphorylation in macrophages in response to viral infection independent of its methyltransferase activity. We found that SMYD2 interacts with the DNA-binding domain (DBD) and IRF association domain (IAD) domains of IRF3 by its insertion SET domain (SETi) and could recruit phosphatase PP1α to enhance its interaction with IRF3, which leads to decreased phosphorylation of IRF3 in the antiviral innate response. Our study identifies SMYD2 as a negative regulator of IFN-I production against virus infection. The new way of regulating IRF3 phosphorylation will provide insight into the understanding of IFN-I production in the innate response and possible intervention of the related immune disorders.