bluuebunny/crossref_metadata_2025 huggingface dataset:
A radical S-adenosyl-L-methionine enzyme and a methyltransferase catalyze cyclopropane formation in natural product biosynthesis
Authors: Jin Wen-Bing , Wu Sheng , Jian Xiao-Hong , Yuan Hua , Tang Gong-Li
Published: July 2018

Cyclopropanation of unactivated olefinic bonds via addition of a reactive one-carbon species is well developed in synthetic chemistry, whereas natural cyclopropane biosynthesis employing this strategy is very limited. Here, we identify a two-component cyclopropanase system, composed of a HemN-like radical S-adenosyl-l-methionine (SAM) enzyme C10P and a methyltransferase C10Q, catalyzes chemically challenging cyclopropanation in the antitumor antibiotic CC-1065 biosynthesis. C10P uses its [4Fe-4S] cluster for reductive cleavage of the first SAM to yield a highly reactive 5′-deoxyadenosyl radical, which abstracts a hydrogen from the second SAM to produce a SAM methylene radical that adds to an sp2-hybridized carbon of substrate to form a SAM-substrate adduct. C10Q converts this adduct to CC-1065 via an intramolecular SN2 cyclization mechanism with elimination of S-adenosylhomocysteine. This cyclopropanation strategy not only expands the enzymatic reactions catalyzed by the radical SAM enzymes and methyltransferases, but also sheds light on previously unnoticed aspects of the versatile SAM-based biochemistry.
Involvement of leptin signaling in the development of cannabinoid CB2 receptor-dependent mirror image pain
Authors: Nozaki Chihiro , Nent Elisa , Bilkei-Gorzo Andras , Zimmer Andreas
Published: July 2018

Neuropathic pain typically appears in a region innervated by an injured or diseased nerve and, in some instances, also on the contralateral side. This so-called mirror image pain is often observed in mice lacking CB2 receptors after sciatic nerve injury, but the underlying mechanisms for this phenotype largely remain unclear. Here we focused on peripheral leptin signaling, which modulates neuropathic pain development and interacts with the endocannabinoid system. Leptin production is induced at the site of nerve injury in CB2-deficient mice (CB2-KO) mice and wild type controls (WT). However, induction of leptin receptor expression was only observed in the injured nerve of CB2-KO mice. This was paralleled by a stimulation of the leptin receptor-downstream STAT3 signaling and an infiltration of F4/80-positive macrophages. Interestingly, an upregulation of leptin receptor expression STAT3 activity and macrophage infiltration was also observed on the non-injured nerve of CB2-KO mice thus reflecting the mirror image pain in CB2-KO animals. Importantly, perineurally-administered leptin-neutralizing antibodies reduced mechanical hyperalgesia, blocked mirror image pain and inhibited the recruitment of F4/80-positive macrophages. These results identify peripheral leptin signaling as an important modulator of CB2 signaling in neuropathic pain.
Detection and Discrimination of Bacterial Colonies with Mueller Matrix Imaging
Authors: Badieyan Saeedesadat , Dilmaghani-Marand Arezou , Hajipour Mohammad Javad , Ameri Ali , Razzaghi Mohammad Reza , Rafii-Tabar Hashem , Mahmoudi Morteza , Sasanpour Pezhman
Published: July 2018

The polarization imaging technique is a powerful approach to probe microstructural and optical information of biological structures (e.g., tissue samples). Here, we have studied the polarization properties of different bacterial colonies in order to evaluate the possibility of bacterial detection and discrimination. In this regard, we have taken the backscattering Mueller matrix images of four different bacteria colonies (i.e., Escherichia coli,Lactobacillus rhamnosus,Rhodococcus erythropolis, andStaphylococcus aureus). Although the images have the potential to distinguish qualitatively different bacterial colonies, we explored more accurate and quantitative parameters criteria for discrimination of bacterial samples; more specifically, we have exploited the Mueller matrix polar decomposition (MMPD),frequency distribution histogram (FDH), and central moment analysis method. The outcomes demonstrated a superior capacity of Mueller matrix imaging, MMPD, and FDH in bacterial colonies identification and discrimination. This approach might pave the way for a reliable, efficient, and cheap way of identification of infectious diseases.
Association of Decreased Handgrip Strength with Reduced Cortical Thickness in Japanese Female Patients with Type 2 Diabetes Mellitus
Authors: Nakamura Miyuki , Inaba Masaaki , Yamada Shinsuke , Ozaki Etsuko , Maruo Saori , Okuno Senji , Imanishi Yasuo , Kuriyama Nagato , Watanabe Yoshiyuki , Emoto Masanori , Motoyama Koka
Published: July 2018

LD-100, a quantitative ultrasonic device, allows us to measure cortical thickness (CoTh). Patients with type 2 diabetes mellitus (T2DM) show high prevalence of sarcopenia. This study aimed to clarify the association of handgrip strength (HGS) with cortical porosis, a major risk for fracture of DM. CoTh and trabecular bone mineral density (TrBMD) at the 5.5% distal radius were assessed in T2DM female patients (n = 122) and non-DM female controls (n = 704) by LD-100. T2DM patients aged older 40 years showed significantly lower HGS and CoTh, but not TrBMD, than non-DM counterparts. Although HGS was significantly and positively correlated with CoTh and TrBMD in T2DM patients, multivariate analysis revealed HGS as an independent factor positively associated with CoTh, but not TrBMD, in T2DM patients, suggesting the preferential association of HGS with cortical, but not trabecular, bone component in T2DM female patients. In conclusion, the present study demonstrated an early decline of HGS in T2DM female patients as compared with non-DM healthy controls after the age of 40 years, which is independently associated with thinner CoTh, but not TrBMD in T2DM patients, and thus suggested that reduced muscle strength associated with DM might be a major factor for cortical porosis development in DM patients.
Generation of hydroxyl radicals from reactions between a dimethoxyhydroquinone and iron oxide nanoparticles
Authors: Lyngsie Gry , Krumina Lelde , Tunlid Anders , Persson Per
Published: July 2018

The hydroxyl radical (·OH) is a powerful oxidant that is produced in a wide range of environments via the Fenton reaction (Fe2+  + H2O2 → Fe3+  + ·OH + OH-). The reactants are formed from the reduction of Fe3+ and O2, which may be promoted by organic reductants, such as hydroquinones. The aim of this study was to investigate the extent of ·OH formation in reactions between 2,6-dimethoxyhydroquinone (2,6-DMHQ) and iron oxide nanoparticles. We further compared the reactivities of ferrihydrite and goethite and investigated the effects of the O2 concentration and pH on the generation of ·OH. The main finding was that the reactions between 2,6-DMHQ and iron oxide nanoparticles generated substantial amounts of ·OH under certain conditions via parallel reductive dissolution and catalytic oxidation reactions. The presence of O2 was essential for the catalytic oxidation of 2,6-DMHQ and the generation of H2O2. Moreover, the higher reduction potential of ferrihydrite relative to that of goethite made the former species more susceptible to reductive dissolution, which favored the production of ·OH. The results highlighted the effects of surface charge and ligand competition on the 2,6-DMHQ oxidation processes and showed that the co-adsorption of anions can promote the generation of ·OH.
Yield effect of applying earthworm castings produced during the oilseed rape-growing season in rice-oilseed rape cropping fields to rice
Authors: Huang Min , Zhao Chunrong , Zou Yingbin , Uphoff Norman
Published: July 2018

In-field earthworm density can be increased by planting oilseed rape during the non-rice growing season as compared to maintaining the rice-growing fields in fallow. This study was conducted to determine the effect on rice yield of earthworm castings produced during the oilseed rape-growing season in rice-oilseed rape cropping fields and to identify the critical factors that contribute to the yield effect. Field microplot experiments were conducted in 2016 and 2017. In 2016, a rice cultivar was grown under a factorial combination of absence (EC0: 0 kg m−2) and presence of earthworm castings (EC1: 17 kg m−2) with three N application rates (9, 12 and 15 g m−2). In 2017, nine rice cultivars were grown under EC0 and EC1 with the moderate N rate as was used in 2016. Results showed that application of earthworm castings produced during the oilseed rape-growing season in rice-oilseed rape cropping fields had a significant positive yield effect on rice. This was attributed to increased panicle m−2 and total aboveground biomass while spikelets panicle−1, spikelet filling percentage, grain weight, and harvest index were not affected. Our study indirectly provides a new evidence that oilseed rape is an excellent previous crop for cereals.
Modulation of gut microbiota by mulberry fruit polysaccharide treatment of obese diabetic db/db mice
Authors: Chen Chun , You Li-Jun , Huang Qiang , Fu Xiong , Zhang Bin , Liu Rui-Hai , Li Chao
Published: July 2018

Increasing evidence indicates that gut microbiota is an important factor in mediating the development of metabolic disorders, especially type 2 diabetes.
Lactoferrin level in breast milk: a study of 248 samples from eight regions in China
Authors: Cai Xiaokun , Duan Yifan , Li Yang , Wang Jie , Mao Yingyi , Yang Zhenyu , Zhao Xianfeng , Zhao Yanrong , Guan Yan , Yin Shian
Published: July 2018

Lactoferrin plays an important role in infant gastrointestinal health and immunity responses.
Programming hierarchical self-assembly of colloids: matching stability and accessibility
Authors: Morphew Daniel , Chakrabarti Dwaipayan
Published: July 2018

A striking correspondence between energetics and kinetics is revealed in the context of optimally programming hierarchical self-assembly pathways for colloidal particles.
Biomonitoring of occupational exposure to 5-FU by assaying α-fluoro-β-alanine in urine with a highly sensitive UHPLC-MS/MS method
Authors: Dhersin Alice , Atgé Benoît , Martinez Béatrice , Titier Karine , Rousset Marine , Sidatt Cheikh El Moustaph Mohamed , Verdun-Esquer Catherine , Molimard Mathieu , Villa Antoine , Canal-Raffin Mireille
Published: July 2018

5-Fluorouracil (5-FU) is one of the most widely antineoplastic drugs handled by healthcare professionals.
Strategy for marker-based differentiation of pro- and anti-inflammatory macrophages using matrix-assisted laser desorption/ionization mass spectrometry imaging
Authors: Khamehgir-Silz Pegah , Schnitter Florian , Wagner Andreas H. , Gerbig Stefanie , Schulz Sabine , Hecker Markus , Spengler Bernhard
Published: July 2018

Mass spectrometric approach for the classification of macrophages, key players in development and progression of atherosclerosis.
Structural differences between toxic and nontoxic HypF-N oligomers
Authors: Capitini Claudia , Patel Jayneil R. , Natalello Antonino , D’Andrea Cristiano , Relini Annalisa , Jarvis James A. , Birolo Leila , Peduzzo Alessia , Vendruscolo Michele , Matteini Paolo , Dobson Christopher M. , De Simone Alfonso , Chiti Fabrizio
Published: July 2018

We have studied two misfolded oligomeric forms of the protein HypF-N, which show similar morphologies but very different toxicities.
1,2-Diarylation of alkenes with aryldiazonium salts and arenes enabled by visible light photoredox catalysis
Authors: Ouyang Xuan-Hui , Cheng Jiang , Li Jin-Heng
Published: July 2018

Visible light-driven three-component alkene 1,2-diarylation with aryldiazonium salts and arenes involving aryl C(sp2)–H functionalization is described.
Enhancement of photoredox catalytic properties of porphyrinic metal–organic frameworks based on titanium incorporation via post-synthetic modification
Authors: He Junhui , Zhang Yajun , He Juan , Zeng Xiaoliang , Hou Xiandeng , Long Zhou
Published: July 2018

PCN-224 is endowed with greatly enhanced photocatalytic performance for both oxidation and reduction via incorporation of titanium as a metal node.
A biosensor based on a 3D-DNA walking machine network and distance-controlled electrochemiluminescence energy transfer for ultrasensitive detection of tenascin C and lead ions
Authors: Xu Zi-Qi , Zhang Pu , Chai Ya-Qin , Wang Hai-Jun , Yuan Ruo
Published: July 2018

An electrochemiluminescence biosensor was proposed based on distance-controlled energy transfer and a 3D-DNA walking machine network.
Domain engineering and full matrix material constants of the [111]c-poled 0.63Pb(Mg1/3Nb2/3)-0.37PbTiO3 single crystal
Authors: Yuan Zhongyuan , Sang Shijing , Sun Enwei , Qi Xudong , Chang Wei-Yi , Zhang Rui , Yang Bin , Jiang Xiaoning , Cao Wenwu
Published: July 2018

Domain engineering was performed on a [111]c-oriented tetragonal ferroelectric 0.63Pb(Mg1/3Nb2/3)-0.37PbTiO3 (PMN-0.37PT) single crystal in order to achieve better piezoelectric properties.
Vibrational entropy of disorder in Cu3Au with different degrees of short-range order
Authors: Benisek A. , Dachs E. , Grodzicki M.
Published: July 2018

The vibrational entropies of disorder in different short-range ordered Cu3Au were studied by calorimetric and DFT methods.
Exploring the electrochemical performance of graphite and graphene paste electrodes composed of varying lateral flake sizes
Authors: Slate Anthony J. , Brownson Dale A. C. , Abo Dena Ahmed S. , Smith Graham C. , Whitehead Kathryn A. , Banks Craig E.
Published: July 2018

A direct relationship is shown with respect to the lateral flake size comprising graphene and graphite electrodes and their corresponding electron transfer properties, with smaller flake sizes (increased edge plane contributions) resulting in improved performance.
Epitaxial 8YSZ/Y2Zr2O7 multilayers: a conductivity and strain study
Authors: Gilardi Elisa , Gregori Giuliano , Maier Joachim
Published: July 2018

Study of the effect of microstructure and strain on Y2Zr2O7 single layers and YSZ/Y2Zr2O7 multilayers.
Solid-state sensors based on Eu3+-containing supramolecular polymers with luminescence colour switching capability
Authors: Neumann L. N. , Calvino C. , Simon Y. C. , Schrettl S. , Weder C.
Published: July 2018

A europium-based metallosupramolecular polymer is reported that exhibits changes of the luminescence colour in response to different types of analytes.
Synthesis of glycerol carbonate over a 2D coordination polymer built with Nd3+ions and organic ligands
Authors: Franco Chris H. J. , Chagas Poliane , Caldeira Gabriela S. , Oliveira Luiz C. A. , de Souza Patterson P. , Leitão Alexandre A. , Amarante Giovanni W. , Diniz Renata
Published: July 2018

The production of glycerol carbonate from glycerol and urea using a 2D coordination polymer as the heterogeneous catalyst.
Di- and tetranuclear transition metal complexes of a tetrakisguanidino-substituted phenazine dye by stepwise coordination
Authors: Lorenz Roxana , Kaifer Elisabeth , Wadepohl Hubert , Himmel Hans-Jörg
Published: July 2018

Coordination of a tetrakisguanidino-substituted phenazine dye in two steps provides rational access to tetranuclear homo- and heterobimetallic complexes.
A new approach of using polyethylene frits for the quantification of sulphur in copper metals by isotope dilution LA-ICP-MS and comparison with conventional IDMS techniques
Authors: Phukphatthanachai Pranee , Vogl Jochen , Traub Heike , Jakubowski Norbert , Panne Ulrich
Published: July 2018

Polyethylene (PE) frits were used to quantify sulphur in copper and its alloys by isotope dilution combined with LA-ICP-MS as an alternative approach to conventional sample preparation.
Facilitating tumor spheroid-based bioassays and in vitro blood vessel modeling via bioinspired self-formation microstructure devices
Authors: Kuo Ching-Te , Lu Siang-Rong , Chen Wei-Min , Wang Jong-Yueh , Lee Si-Chen , Chang Hsiu-Hao , Wo Andrew M. , Chen Benjamin P. C. , Lee Hsinyu
Published: July 2018

We present a bioinspired self-formation microdevice to boost both tumor spheroid-based bioassays and in vitro modeling of blood vessels.
A tumor treatment strategy based on biodegradable BSA@ZIF-8 for simultaneously ablating tumors and inhibiting infection
Authors: Wu Qiong , Li Mei , Tan Longfei , Yu Jie , Chen Zengzhen , Su Liuhui , Ren Xiangling , Fu Changhui , Ren Jun , Li Laifeng , Cao Feng , Liang Ping , Zhang Yu , Meng Xianwei
Published: July 2018

Biodegradable BSA@ZIF-8 can treat cancer by tumor microwave ablation, while simultaneously inhibiting bacteria and resisting infection.
Ultrasonication-assisted synthesis of ternary-component Ni3AlxFe1−x-layered double hydroxide nanoparticles for the oxygen evolution reaction in a neutral solution
Authors: Jafari Foruzin Leila , Habibi Biuck , Rezvani Zolfaghar
Published: July 2018

In this study, ultrasonication, a facile and rapid process, was utilized for the preparation of ternary-component layered double hydroxides (LDHs), Ni3AlxFe1−x-LDHs, as the electrocatalyst material for the oxygen evolution reaction (OER) in a neutral solution.
Green synthesis of Pt–Pd bimetallic nanoparticle decorated reduced graphene oxide and its robust catalytic activity for efficient ethylene glycol electrooxidation
Authors: Raj kumar T. , Jin Yoo Dong , Kim Ae Rhan , Gnana kumar G.
Published: July 2018

A simple one-pot green synthesis technique is developed to prepare the Pt–Pd bimetallic nanoparticles decorated reduced graphene oxide nanocomposite and its robust catalytic activity for efficient and durable ethylene glycol oxidation is realized.
Amphiphilic polypyrrole-poly(Schiff base) copolymers with poly(ethylene glycol) side chains: synthesis, properties and applications
Authors: Molina Brenda G. , Cianga Luminita , Bendrea Anca-Dana , Cianga Ioan , del Valle Luis J. , Estrany Francesc , Alemán Carlos , Armelin Elaine
Published: July 2018

New amphiphilic poly(ethylene glycol) (PEG)-grafted random intrinsically conducting copolymers which combine three different functionalities have been engineered, prepared and characterized.
Magnetic mesoporous TiO2 microspheres for sustainable arsenate removal from acidic environments
Authors: Zhao Yujuan , Wang Changyao , Wang Shuai , Wang Chun , Liu Yupu , Al-Khalaf Areej Abdulkareem , Hozzein Wael N. , Duan Linlin , Li Wei , Zhao Dongyuan
Published: July 2018

Unique magnetic mesoporous TiO2 microspheres exhibit superior arsenate removal performance and high stability in acidic environments.
A new method for determination of gas–liquid mass transfer coefficients by direct measurement of gas uptake by flow NMR
Authors: Buser Jonas Y. , Luciani Carla V.
Published: July 2018

Anin situmethod for determination of the overall volumetric mass transfer coefficients by direct observation and quantitation of dissolved gases that contain NMR active nuclei is presented.
Auxetic multiphase soft composite material design through instabilities with application for acoustic metamaterials
Authors: Li Jian , Slesarenko Viacheslav , Rudykh Stephan
Published: July 2018

We investigate the instability-induced pattern transformations in 3D-printed soft composites consisting of stiff inclusions and voids periodically distributed in a soft matrix, and we illustrate an application of these reversible pattern transformations as tunable acoustic metamaterials.
Extracting the surface tension of soft gels from elastocapillary wave behavior
Authors: Shao X. , Saylor J. R. , Bostwick J. B.
Published: July 2018

Elastocapillary waves appear on the surface of soft gels and by measuring the dispersion of these waves we are able to extract the surface tension.
Dendrimer-induced colloids towards robust fluorescent photonic crystal films and high performance WLEDs
Authors: Peng Gang , Zhu Zhijie , Tian Yu , Tong Yu-long , Cui Ting-Ting , Wang Cai-Feng , Chen Su
Published: July 2018

We fabricated dendrimer-modified colloids and utilized them to fabricate PC films with good mechanical strength and high performance WLEDs.
Self-healing responsive chiral photonic films for sensing and encoding
Authors: Chen Jiayao , Xu Lirong , Lin Xiaofeng , Chen Ruilian , Yu Di , Hong Wei , Zheng Zhikun , Chen Xudong
Published: July 2018

Chiral photonic films formed by cellulose nanocrystals co-assembled with self-healing hydrogels exhibit self-healing property, solvent sensitivity and CPL-dependent anti-counterfeiting.
Self-Esteem, Self-Efficacy, and Social Support as Predictors of Communicative Participation in Adults Who Stutter
Authors: Boyle Michael P. , Beita-Ell Carolina , Milewski Kathryn M. , Fearon Alison N.
Published: July 2018

Purpose

This study aimed to identify contributors to communicative participation in adults who stutter. Specifically, it was of interest to determine whether psychosocial variables of self-esteem, self-efficacy, and social support were predictive of communicative participation beyond contributions of demographic and speech-related variables.

Method

Adults who stutter (
N
= 339) completed an online survey that included measures of communicative participation, self-esteem, self-efficacy, social support, self-reported speech-related variables (speech usage, number of years stuttering, history of treatment and self-help support group participation for stuttering, and physical speech disruption severity), and demographics (age, sex, living situation, education, and employment status). Hierarchical regression was performed for prediction of communicative participation, in addition to calculating Spearman correlations between social roles variables, communicative participation, and physical speech disruption severity.

Results

After controlling for demographic and speech-related variables, self-esteem, self-efficacy, and social support each significantly predicted communicative participation in adults who stutter. Large correlations were observed between communicative participation and measures of social roles, whereas medium correlations were observed between physical speech disruption severity and measures of social roles.

Conclusions

Communicative participation in adults who stutter is associated with a variety of demographic, speech-related, and psychosocial variables. Speech-language pathologists should be aware of predictors of communicative participation such as self-esteem, self-efficacy, and social support, in addition to severity of physical speech disruptions. They should consider and evaluate these factors in clients who stutter and target them in treatment if necessary.
The VLT-FLAMES Tarantula Survey
Authors: Schneider F. R. N. , Ramírez-Agudelo O. H. , Tramper F. , Bestenlehner J. M. , Castro N. , Sana H. , Evans C. J. , Sabín-Sanjulián C. , Simón-Díaz S. , Langer N. , Fossati L. , Gräfener G. , Crowther P. A. , de Mink S. E. , de Koter A. , Gieles M. , Herrero A. , Izzard R. G. , Kalari V. , Klessen R. S. , Lennon D. J. , Mahy L. , Maíz Apellániz J. , Markova N. , van Loon J. Th. , Vink J. S. , Walborn N. R.
Published: July 2018

The 30 Doradus (30 Dor) nebula in the Large Magellanic Cloud (LMC) is the brightest HII region in the Local Group and a prototype starburst similar to those found in high redshift galaxies. It is thus a stepping stone to understand the complex formation processes of stars in starburst regions across the Universe. Here, we have studied the formation history of massive stars in 30 Dor using masses and ages derived for 452 mainly OB stars from the spectroscopic VLT-FLAMES Tarantula Survey (VFTS). We find that stars of all ages and masses are scattered throughout 30 Dor. This is remarkable because it implies that massive stars either moved large distances or formed independently over the whole field of view in relative isolation. We find that both channels contribute to the 30 Dor massive star population. Massive star formation rapidly accelerated about 8 Myr ago, first forming stars in the field before giving birth to the stellar populations in NGC 2060 and NGC 2070. The R136 star cluster in NGC 2070 formed last and, since then, about 1 Myr ago, star formation seems to be diminished with some continuing in the surroundings of R136. Massive stars within a projected distance of 8 pc of R136 are not coeval but show an age range of up to 6 Myr. Our mass distributions are well populated up to 200 M⊙. The inferred IMF is shallower than a Salpeter-like IMF and appears to be the same across 30 Dor. By comparing our sample of stars to stellar models in the Hertzsprung–Russell diagram, we find evidence for missing physics in the models above log L/L⊙ = 6 that is likely connected to enhanced wind mass loss for stars approaching the Eddington limit. Our work highlights the key information about the formation, evolution and final fates of massive stars encapsulated in the stellar content of 30 Dor, and sets a new benchmark for theories of massive star formation in giant molecular clouds.
Deep LOFAR 150 MHz imaging of the Boötes field: Unveiling the faint low-frequency sky
Authors: Retana-Montenegro E. , Röttgering H. J. A. , Shimwell T. W. , van Weeren R. J. , Prandoni I. , Brunetti G. , Best P. N. , Brüggen M.
Published: July 2018

We have conducted a deep survey (with a central rms of 55 μJy) with the LOw Frequency ARray (LOFAR) at 120–168 MHz of the Boötes field, with an angular resolution of 3.98″ × 6.45″, and obtained a sample of 10 091 radio sources (5σ limit) over an area of 20 deg2. The astrometry and flux scale accuracy of our source catalog is investigated. The resolution bias, incompleteness and other systematic effects that could affect our source counts are discussed and accounted for. The derived 150 MHz source counts present a flattening below sub-mJy flux densities, that is in agreement with previous results from high- and low- frequency surveys. This flattening has been argued to be due to an increasing contribution of star-forming galaxies and faint active galactic nuclei. Additionally, we use our observations to evaluate the contribution of cosmic variance to the scatter in source counts measurements. The latter is achieved by dividing our Boötes mosaic into 10 non-overlapping circular sectors, each one with an approximate area of 2 deg2. The counts in each sector are computed in the same way as done for the entire mosaic. By comparing the induced scatter with that of counts obtained from depth observations scaled to 150 MHz, we find that the 1σ scatter due to cosmic variance is larger than the Poissonian errors of the source counts, and it may explain the dispersion from previously reported depth source counts at flux densities S <  1 mJy. This work demonstrates the feasibility of achieving deep radio imaging at low-frequencies with LOFAR.
Investigation on the melting process of phase change material in a square cavity with a single fin attached at the center of the heated wall
Authors: Arıcı Müslüm , Tütüncü Ensar , Karabay Hasan , Campo Antonio
Published: July 2018

In this study, melting of a phase change material (PCM) in a square cavity with a single fin attached at the center of the heated wall is studied numerically employing the enthalpy-porosity method. The opposite wall to the heated wall in the square cavity is cold. The other two adjacent walls are thermally insulated. Paraffin wax is chosen as a PCM due to its demonstrable favorable properties. The thermophysical properties of the paraffin wax are assumed to be a dual function of temperature and phase. The influence of the fin length on the melting process of the paraffin wax is examined. Moreover, the orientation of the square cavity on the melting process is scrutinized. The numerical results elucidate that the melting rates increase significantly by embedding the fin into the paraffin wax. As the fin length is incremented, the melting rate intensifies considerably during the early stages of melting. However, the effect of the fin length on the melting rate diminishes after a long period of heating has happened. It is also observed that the melting rate can be augmented significantly by changing the orientation of the heated wall in the square cavity.
State hyperstructures of tree automata based on lattice-valued logic
Authors: Ghorani Maryam
Published: July 2018

In this paper, an association is organized between the theory of tree automata on one hand and the hyperstructures on the other hand, over complete residuated lattices. To this end, the concept of order of the states of a complete residuated lattice-valued tree automaton (simply L-valued tree automaton) is introduced along with several equivalence relations in the set of the states of an L-valued tree automaton. We obtain two main results from this study: one of the relations can lead to the creation of Kleene’s theorem for L-valued tree automata, and the other one leads to the creation of a minimal v-valued tree automaton that accepts the same language as the given one.
Analysis of a discrete-time repairable queue with disasters and working breakdowns
Authors: Gao Shan , Wang Jinting , Van Do Tien
Published: July 2018

In this paper, we analyse a discrete-time queue with a primary server of high service capacity and a substitute server of low service capacity. Disasters that only arrive during the busy periods of the primary server remove all customers from the system and make the primary server breakdown. When the primary server fails and is being repaired, the substitute server handles arriving customers. Applying the embedded Markov chain technique and the supplementary variable method, we determine the distribution of the system length at departure epochs and the joint distribution of the queue length and server’s state at an arbitrary instant. Then we derive the sojourn time distribution. We also provide the probability generating function of the time between failures. Some numerical examples are delivered to give an insight into the impact of system parameters on performance measures and a cost function.
A robust possibilistic programming model for water allocation problem
Authors: Fazli-Khalaf Mohamadreza , Fathollahzadeh Karo , Mollaei Amir , Naderi Bahman , Mohammadi Mohammad
Published: July 2018

Over the past few years, water allocation problem has increasingly spotlighted by governments, researchers and practitioners. As water plays an important role in people’s life and business environment, the problem of water allocation should be considered carefully to properly satisfy demand of water consumers. In the real world applications, problems like water allocation are uncertain owing to long-term planning horizon of such problems. Therefore, employing efficient methods for tackling uncertainty of parameters should be regarded by field researchers. In this regard, this paper proposes a bi-objective mathematical programming model for water distribution network design. The extended model maximizes total profit of water distribution as well as maximizing priority of water transferring among water customer zones. Then, to cope effectively with uncertainty of parameters, a novel robust possibilistic programming method is applied. Then, fuzzy and robust fuzzy programming models are compared against each other and output results confirm superiority and effective performance of the robust fuzzy model in the water allocation problem. Also, output results of the extended model show its accurate performance that results in applicability of the model as a strong planning tool in real world cases.
Nous allons à Mons. Du régime à l’adjet
Authors: Roig Audrey
Published: July 2018

Si elle paraissait évidente hier, l’identification de la fonction du complément à Mons dans Nous allons à Mons pose aujourd’hui beaucoup de problèmes aux enseignants et aux concepteurs de manuels. Depuis la séparation des compléments du verbe et des compléments de phrase prônée par le Ministère dans les années 1970 en France, il est en effet devenu difficile d’indexer les compléments comme à Mons, non suppressibles comme les COD/COI mais renseignant sur les circonstances comme les compléments circonstanciels (CC), sinon en en faisant une catégorie à part (e.g. le complément essentiel de lieu). La distinction COD/COI et CC ne va pas sans rappeler l’opposition des actants et des circonstants chez Tesnière (1959) qui, cependant, reconnaissait très vite déjà les limites de ce binôme en français. C’est en réponse à cette difficulté que le terme d’adjet a vu le jour, lequel n’apporte pas, cependant, toutes les réponses espérées.
Le statut énonciatif des unités dites “transposées” en discours indirect libre
Authors: Gollut Jean-Daniel , Zufferey Joël
Published: July 2018

La transposition, concept central de l’approche grammaticale du discours rapporté, a été remise en question par la redéfinition du champ en termes de représentation du discours autre. Le changement de paradigme a imposé de renoncer au schéma selon lequel un énoncé, censément premier, serait transféré dans un discours d’accueil. Tout en adoptant l’ordre sémiologique de la représentation, les auteurs proposent ici de réhabiliter l’opération de transposition dans la compréhension du discours indirect libre, non sans réévaluer le statut énonciatif des unités concernées. Car si, dans ce cadre, les pronoms de troisième personne, l’imparfait et les temps qui lui sont associés, de même que les localisateurs spatiotemporels sont des formes censées convenir au régime cotextuel de base (plan énonciatif de l’histoire pour le récit classique), elles conservent, en tant que produit d’une transposition, une part de la subjectivité propre au discours représenté. En dépit de leur forme anaphorique, ce ne sont pas de purs morphèmes narratifs amenés à se combiner, dans la syntagmatique du DIL, avec d’autres éléments de nature discursive : ils fonctionnent eux-mêmes à titre de quasi-indicateurs. Cette spécificité des unités transposées par rapport aux domaines d’emploi définis par Benveniste ne va pas sans rendre problématique la conception habituelle du discours indirect libre comme « mélange de voix ».
Rituels épistolaires dans les lettres des poilus peu et moins lettrés : une analyse contrastive
Authors: Vicari Stefano
Published: July 2018

Dans cet article, on propose une analyse contrastive des rituels épistolaires dans les lettres des poilus selon le niveau d’instruction des scripteurs, des moins aux plus lettrés. Suite à la présentation des remarques méthodologiques, des objectifs et de la constitution du corpus, il s’agira d’exposer le cadre théorique et les recherches déjà menées sur les lettres des scripteurs peu lettrés afin de mieux cerner les enjeux des analyses. Enfin, on passera à l’analyse des formules d’ouverture et de clôture des lettres ainsi que des transitions entre ces parties formulaires et le corps de la lettre, dans le but de dégager les différences et les ressemblances entre les scripteurs peu lettrés et plus lettrés.
Francographe : un outil d’évaluation des compétences orthographiques d’enfants entre 7 et 12 ans
Authors: Rodi Mireille , Geoffre Thierry , Epars et Florence
Published: July 2018

Cet article présente le projetFrancographe, fruit de la collaboration de chercheurs canadiens, français et suisses. Cette recherche a pour objectif l’étude de la dynamique développementale des habiletés orthographiques d’élèves francophones. Le recueil de données se fera auprès de 1’000 élèves, de la 1è re à la 6eprimaire, dans trois pays différents. Après un état des lieux des épreuves psychométriques permettant d’évaluer qualitativement et quantitativement les compétences orthographiques, la présente communication détaille un des volets de la rechercheFrancographe, à savoir un nouveau test en orthographe grammaticale, susceptible de permettre un étalonnage des réussites progressives des élèves de primaire et des procédures qu’ils utilisent. Les résultats obtenus pourront définir les priorités d’apprentissage à l’école primaire afin de favoriser, notamment, un enseignement de la morphographie du français en lien avec l’évolution des habiletés des élèves. L’ambition, à terme, est de parvenir à proposer des outils de positionnement affinés et étalonnés en orthographes lexicale et grammaticale, à destination des enseignants et des professionnels intervenant auprès d’enfants présentant des troubles spécifiques du langage écrit.
Does first word development in bilingual French-Portuguese toddlers mirror monolingual one? A study exploring executive function abilities
Authors: Valente Daniela , Kern Sophie , dos Santos Christophe
Published: July 2018

L ’objectif de ce travail est d’évaluer le dédeveloppement lexical, précoce chez les enfants bilingues et d’explorer le lien possible entre la, taille du vocabulaire et les fonctions exécutives. Nous avons testé 15,bilingues français-portugais (7 de 16 mois et 8 de 24 mois). Leur, développement langagier a été évalué avec l'Inventaire du développement, communicatif français et portugais (adaptations du CDI MacArthur-Bates, Fenson et al., 2007). Des questionnaires parentaux ont été utilisés pour,évaluer la dominance linguistique (PaBiQ, Tuller, 2015), les stades de, développement (ASQ-3™, Squires et al., 2009) et les fonctions exécutives,(BRIEF-P, Gioia, Aspy, … Isquith, 2003). Nous avons calculé la taille du, vocabulaire dans chacune des langues, le vocabulaire total et le vocabulaire, conceptuel total et comparé avec les normes des monolingues. Presque, tous les participants ont un vocabulaire total dans chacune des langues,(français ou portugais) et un vocabulaire conceptuel total similaire à celui, des monolingues portugais et français. Leur vocabulaire total,(français+portugais) est par contre supérieur à celui des monolingues. Il, existe une corrélation entre la taille du vocabulaire et la mémoire de travail,(Stokes & Klee, 2009), mais aucune avec l'inhibition. Ces résultats donnent, un meilleur aperçu du processus de développement du langage bilingue.
Reformulations avec et sans marqueurs : étude de trois entretiens de l’oral
Authors: Eshkol-Taravella Iris , Grabar Natalia
Published: July 2018

La communication porte sur l’analyse des reformulations produites dans le discours oral. La reformulation est prise au sens large en tant que procédé de modification d’un segment par un autre mais elle garde toujours un lien sous-jacent entre les deux segments reformulés. Ce lien se manifeste à différents niveaux linguistiques : lexical, morphologique, sémantico-pragmatique. Généralement, les études sur la reformulation se fondent sur la présence de marqueurs. Le travail présenté montre que la reformulation peut être réalisée sans marqueurs également. Le segment source est interrompu et suivi par un segment reformulé. Cette interruption peut être « remplie » par un élément lexical : un marqueur qui introduit la reformulation (marqueur de reformulation « classique », marqueur de correction, marqueur d’exemplification, marqueur de conclusion), un élément disfluent (amorce, interjection, hésitation, marqueur discursif), un présentateur. Les raisons de la modification peuvent être nombreuses : correction, paraphrase, explication, définition, justification, conclusion, précision, dénomination, exemplification, etc. A partir de cette définition du procédé de reformulation, celui-ci est modélisé par un jeu d’étiquettes correspondantes selon lesquelles le corpus est annoté manuellement. La démarche est inductive et permet d’appréhender la reformulation sous un autre angle, ainsi que d’observer et de quantifier certaines de ses caractéristiques.
Pour une micro-diachronie de l’oral : le corpus ESLO-MD
Authors: Abouda Lotfi , Skrovec Marie
Published: July 2018

Extrait des Enquêtes Socio-Linguistiques à Orléans, corpus oral constitué en deux temps à 40 ans d'intervalle (ESLO 1968-1971, ESLO2 2008-), ESLO-MD (ESLO Micro-Diachronie) est un corpus oral échantillonné d’un million de mots, quantitativement et qualitativement équilibré entre ses deux parts micro-diachroniques. Constitué initialement en 2014 pour les besoins d’une étude particulière, le corpus ESLO-MD a montré, au fil des ans et des recherches, une certaine efficacité à éclairer sous un jour nouveau un certain nombre de phénomènes linguistiques. Par la prise en compte d’une dimension micro-diachronique inédite, ESLO-MD permet en effet utilement de compléter l’éventail des données disponibles pour l’étude de la variation et du changement en français oral hexagonal contemporain. Cette contribution, qui entend présenter le travail de constitution de ce corpus, parallèlement à sa mise à disposition pour la communauté scientifique, expose les critères de sélection des données ainsi que les modalités de leur diffusion, dans la perspective d'un accès facilité à des données sources susceptibles d'être réexaminées ou réexploitées par d'autres membres de la communauté.
Les alternances objet / oblique en français : goûter (à) un vin, dévaler (de) la colline, chercher (après) ses clés, etc.
Authors: Huyghe Richard , Corminboeuf Gilles
Published: July 2018

L’étude porte sur le cas où deux constructions, l’une à complément d’objet, l’autre à complément oblique, sont en concurrence pour un même verbe (goûter X / goûter à X, chercher X / chercher après X, pousser X / pousser sur X). Nous définissons dans un premier temps les conditions exactes des alternances étudiées et clarifions plusieurs points relatifs à la polysémie verbale, au statut syntaxique du SP et à l’extension d’emploi de l’alternance. Nous consacrons la seconde section du papier à l’étude des contreparties sémantiques éventuellement associées à l’existence de deux constructions distinctes. Nous établissons une tripartition des alternances, fondée sur la littérature scientifique à disposition, et nous montrons que la classification proposée ne couvre pas l’ensemble des cas répertoriés en français. Nous proposons une approche multifactorielle du phénomène, qui ménage notamment une place aux faits de variation inter-locuteurs.
La construction à un point X en relation avec l’exclamative en à quel point
Authors: Nakamura Takuya , Marque-Pucheu Christiane
Published: July 2018

Dans cette étude préalable à une description plus générale des exclamatives en à quel point (AQP), nous examinons les distributions des SP à un point X (AUPX) comportant un déterminant indéfini. Ces derniers doivent sous-tendre AQP exclamatif (et interrogatif) selon une hypothèse présuppositionelle sur les phrases interrogatives et exclamatives mettant en jeu un élément Qu- (cf. Michaelis & Lambrecht). Nous démontrons que, contrairement à la distribution générale de quel, AQP ne possède que l’emploi exclamatif indirect, excluant l’exclamatif direct et les interrogatifs direct et indirect, ce qui va à l’encontre du jugement d’acceptabilité de linguistes comme J.-C. Milner. Les syntagmes AUPX reliés au syntagme AQP expriment exclusivement le haut degré, en raison 1) du sens lexical de « seuil/limite » que le nom point y revêt et 2) d’un paradigme de modifieurs qui exclut une variation libre, condition préalable de la question en quel. Ils peuvent être considérés comme une construction. Ces modifieurs (adjectif ou relatif), en distribution complémentaire avec une forte intonation exclamative, décrivent l’incrédulité ou l’indicibilité du locuteur, traduisant son appréciation subjective vis-à-vis du haut degré. Ils constituent souvent le prédicat principal d’une exclamative indirecte. AQP n’est alors qu’une variante syntaxique subordonnée d’AUPX.
Appropriation du français en contexte plurilingue africain : le nouchi dans la dynamique sociolinguistique de la Côte d’Ivoire
Authors: Atsé N’Cho Jean-Baptiste
Published: July 2018

La Côte d’Ivoire est l’un des pays d’Afrique linguistiquement hétérogène où aucune de ses langues locales n’a le statut de langue nationale ou ne sert de moyen de communication interethnique. L’objectif de cette contribution est de montrer comment, dans le contexte du plurilinguisme ivoirien, le nouchi qui, autrefois était utilisé comme un code secret par les jeunes des quartiers populaires d’Abidjan, s’étend désormais dans toutes les sphères de la vie privée et publique du pays. Après analyse, l’étude révèle que cette variété argotique joue un rôle véhiculaire indéniable au point de s’imposer comme la langue nationale de la Côte d’Ivoire. S’appuyant sur un corpus de mots et d’expressions nouchi extraits d’affiches publicitaires et de chansons zouglou, l’approche théorique de cette étude relève de la sociolinguistique variationniste et descriptiviste.
Modified Fe3O4/HAp Magnetically Nanoparticles as the Carrier for Ibuprofen: Adsorption and Release Study
Authors: Mohammadi-Aghdam Sarvin , Valinezhad-Saghezi Bahareh , Mortazavi Yousef , Qhoreishi Seyedeh
Published: July 2018

The adsorption capacity and release attributes of magnetic Fe3O4@hydroxyapatite (Fe3O4/HAp) nanoparticles for drug molecules can be improved by modified their surfaces with logical chosen organic groups. The internal surface of nanoparticles was functionalized with (3-aminopropyl) trimethoxysilane (APTS). Comparative studies of their adsorption and release properties for various model drug molecules (such as pure hydroxyapatite, Fe3O4@hydroxyapatite and functionalized Fe3O4@hydroxyapatite) were then conducted. The characteristic of the obtained materials was performed with X-ray-diffraction (XRD), energy dispersive X-ray microanalysis (EDS), fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), UV-Vis analysis, vibrating sample magnetometer (VSM) and transmission electron microscopy (TEM). Results show that functionalized magnetic Fe3O4@hydroxyapatite nanoparticles leads than a substantial decrease of the drug delivery rate in pH=6.8 after investigated drug release in intestine environment. In addition, the results demonstrate that high adsorption capacity for drug and slower drug release rate was obtained after functionalized nanoparticles than Fe3O4@hydroxyapatite and pure hydroxyapatite.
Triterpenoids from Momordica balsamina with a Collateral Sensitivity Effect for Tackling Multidrug Resistance in Cancer Cells
Authors: Ramalhete Cátia , Mulhovo Silva , Lage Hermann , Ferreira Maria-José
Published: July 2018

The collateral sensitivity effect is among the most promising strategies for overcoming multidrug resistance in cancer. In this work, 28 cucurbitane-type triterpenoids (1–28), previously isolated from the African medicinal plant Momordica balsamina and its derivatives, were evaluated for their collateral sensitivity effect on three different human cancer entities, gastric (EPG85-257), pancreatic (EPP85-181), and colon (HT-29), each with two different multidrug-resistant variants. One was selected for its resistance to daunorubicin (EPG85-257RDB, EPP85-181RDB, HT-29RDB) and the other was selected for its resistance to mitoxantrone (EPG85-257RNOV, EPP85-181RNOV, HT-29RNOV). On gastric cell lines, the best results were obtained for compounds 3 and 10, which exhibited a collateral sensitivity effect together with high antiproliferative activity. In turn, on colon cancer cell lines, the best multidrug resistance-selective antiproliferative effects were observed for derivatives 11, 13, and 15, which showed collateral sensitivity effects against both resistant variants. Compounds 11 and 3 were also the most selective against the multidrug resistance pancreatic cells lines. Some compounds, such 6, 10, 11 and 15, were previously found to be strong P-glycoprotein modulators, thus highlighting their potential as promising leads for overcoming multidrug resistance in cancer cells.