bluuebunny/crossref_metadata_2025 huggingface dataset:
Multiple keratoacanthomas following the Moderna mRNA-1273 Covid-19 vaccination resolved with 5-FU treatment: Case Report (Preprint)
Authors: Ahmed Fahad , Memon Nashwah , Haque Adel
Published: September 2022

UNSTRUCTURED

Cutaneous reactions have been commonly associated with the Moderna mRNA Covid-19 vaccine. Of the reported cutaneous side effects, there have not been any associations reported yet of keratoacanthoma after Covid-19 mRNA vaccination. We report a novel case of an 86 year old man who had an eruption of multiple keratoacanthomas 2 weeks after inoculation with the Moderna mRNA-1273 vaccine that resolved following treatment with intralesional 5-fluorouracil.
Influence of physical activity in childhood on bone state, physical capabilities of postmenopausal women with osteoporosis and vertebral fractures
Authors: Rybina О.S.
Published: September 2022

Background. To date, the results of scientific research continue to discuss the long-term effect of regular sports in childhood on the prevention of bone quality loss in postmenopausal women, as well as the positive effect of a sufficient level of physical activity in the prevention of osteoporotic fractures in women older age. The purpose was to assess the effect of physical activity (PA) in childhood on the state of BT, physical capabilities of postmenopausal women with osteoporosis and vertebral fractures. Materials and methods. As part of a single-stage study, 115 postmenopausal women aged 50–89 years were examined. For the analysis, the selected individuals were divided into groups: I (control) group— women without any history of osteoporotic fractures (n=84), II (main) group — patients with vertebral fractures at the level of the thoracic and lumbar spine (n = 31). With the help of the author’s questionnaire, the peculiarities of the PA of women were assessed at different age periods of life and at the time of the survey. Results. We did not find significant differences in the frequency and types of sports in childhood between the groups depending on vertebral fractures. Most of the women with vertebral fractures (85.7 %) maintained regular physical activity, sports in childhood up to 10 years (41.7 % in the control group, p = 0.04), moreover, in 57.1% of the surveyed, these activities lasted 1–4 years and did not differ from the indicator of the control group. The type, frequency and duration of FU training and PH procedures, as well as the level of physical activity, did not significantly differ in patients depending on the presence of vertebral fractures, but the group of women regularly exercising in sports sections was significantly higher among patients with vertebral fractures (41.9 %) compared with women without vertebral fractures (10.7 %, p = 0.0002). In addition, the part of women in the control group who regularly maintained a sufficient level of PA (6 or more hours a day) was significantly higher (14.3 %) compared with the corresponding result of the main group (3.2 %, p = 0.04). Conclusions. Women with vertebral body fractures are more likely to engage in PE in sports sections and have a lower level of total PA compared to patients without vertebral fractures. The regularity, duration of PE, and the age at which sports start in childhood may influence the risk of osteoporotic fractures of the vertebral bodies in postmenopausal women, which requires further study.
Comparative evaluation of the effectiveness of parenteral and oral forms of diclofenac sodium and meloxicam in patients with symptomatic osteoarthritis of the knee joints
Authors: Povoroznyuk V.V. , Bystrytska M.A. , Musiienko A.S. , Zaverukha N.V. , Grygorieva N.V. , Tkachuk A.A. , Solonenko T.Y.
Published: September 2022

Nonsteroidal anti-inflammatory drug are considered at the cornerstone drug therapy for osteoarthritis (OA) because their main function is to relieve pain and reduce inflammation. The aim of the study was to compare the efficacy of treatment of patients with symptomatic knee osteoarthritis (KOA) using the diclofenac sodium and meloxicam. Materials and methods. The study included 40 females aged 50–75 years with symptomatic KOA, and were divided into 2 groups: group I — 20 subjects receiving diclofenac sodium; group II — 20 subjects receiving meloxicam. The intensity of the pain syndrome and the functional of the knee were assessed using the WOMAC scale, the four-component VAS, the Lequesne index, and functional tests at each visit. The safety of medication was determined by the frequency adverse events. Results. Patients of two groups did not differ by age and initial level of knee pain. During the treatment, patients in both groups showed a reduction of pain intensity by VAS on 5 and 20 days of therapy (p<0.01) without significant difference between groups, however in the subjects of group I the level of pain intensity by VAS on days 2 and 3 of treatment was significantly lower compared to group II (p = 0.003 and p = 0.03, respectively). In patients of both groups were revealed a significant reduction of pain, stiffness and physical function by WOMAC subscales on 5 and 20 days of treatment, but in group I the intensity of pain after 5 days of treatment was significantly lower (t = 2.8, p < 0.004) compared to group II. Conclusions. The treatment of patients with knee OA using the diclofenac sodium and meloxicam is effective, but in the case of diclofenac sodium analgesic effect were faster, already on 2 and 3 days of treatment were detected significantly lower pain intensity by VAS and on 5 days by WOMAC pain subscale.
Information letter “On innovations in the healthcare system”
Authors: Authors No
Published: September 2022

No abstract
Objetos de uso corporal del período Formativo en el sur de los Valles Calchaquíes
Authors: Cortés Leticia Inés
Published: September 2022

This work presents a set of objects of bodily use assigned to the Formative period (ca. 1500 BC-1000 AD) recovered from various sites in the Cajón Valley, the Santa María Valley and the western foothills of the Aconquija mountain range in the southern Calchaquíes Valleys of northwest Argentina. The sample comprises 1973 items, including beads, pendants, appliqués, bracelets and rings made of different raw materials: rocks, minerals, shells, ceramics and metals. Items are quantified and analyzed by type, raw material, shape and color. This work offers discussion and contextualization of the sample as it relates to other objects of bodily use published from the study area.
Profilaxis urbana y arquitectura en la epidemia de peste bubónica en el norte de Chile a inicios del siglo XX
Authors: Galeno-Ibaceta Claudio
Published: September 2022

Northern Chile’s port cities experienced bubonic plague epidemics in the early 20th century. The first was in Iquique in 1903. Then, the plague reached Antofagasta in 1904 and devastated Pisagua in 1905. That same year, Chile established a health checkpoint to screen ships entering the country at its northern border with Peru in Arica. Although outbreaks were quelled at times through the lazarettos (isolation hospitals) built to fight the disease and urban prophylactic measures, resurgences of varying intensities continued through the 1920s. The succession of epidemics and the information derived from the urgency of controlling them make it possible to understand and evaluate whether the architectural and urban prevention measures were adequate to control the disease and to identify the impact of these operations.
Konstruksi Ide Xi Jinping dalam Belt And Road Initiative
Authors: Darmawan Arief Bakhtiar , Dwianto Rahmad Agus , Akmala Herdho Husna
Published: September 2022

This paper aims to understand the role of Xi Jinping's ideas and perceptions about China's rise in the Belt and Road Initiative (BRI). It released by Xi Jinping in 2013 as the one of ambitious policy to drive China's rise as the world power. He has a strong position in Chinese politics. In addition to leading the government, Xi is the military's commander-in-chief and has the potential to serve as president for three terms. His thoughts have even entered into the Constitution of the Chinese Communist Party. Xi's accumulation of power began to be juxtaposed with Mao's power who had a sacred position in society. Using constructivist approach, this paper attempts to analyze the role of non-material factor, such as the ideas of leader, in determining the direction of Chinese foreign policy. As the qualitative research, primary data obtained from the analysis of official government documents related to Xi Jinping's speech, the Chinese constitution, BRI, as well as official websites. Meanwhile, mass media news, scientific publications as well as other research reports consider as secondary data. It examines the practice of China's foreign policy is controlled and shaped by Xi Jinping's idea of China's rise. As a result, his ideas have played a role in changing the ways of diplomacy and the use of power that see BRI as China's global strategy, especially in China's relations with the US at the global level and cooperation with Southeast Asian and East Asian countries in order to streamline the BRI project.
The relationship between mentoring function of resort managers in Gangwon region and job satisfaction of resort employees
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lee Kyung-Young , Hwang Chan-Gyu
Published: September 2022

Objectives The purpose of this study is to investigate the relationship between mentoring function and job satisfaction after setting the working period of resort workers as a control variable.
Methods 400 people who work at resorts in Gangwon-do were set as the research subjects, and a written survey through direct visits and an online form were distributed to community sites within the organization. Frequency analysis, descriptive statistical analysis, correlation analysis, regression analysis, and hierarchical regression analysis were performed based on 232 copies of data collected from May 18 to May 26 in 2017 to analyze the relationship between variables.
Results First, the longer the working period of resort workers, the higher the job satisfaction. Second, job satisfaction increases as the mentoring function is strengthened in a situation where the working period is controlled. Third, the career development function among mentoring functions did not increase job satisfaction in a situation where the working period was controlled. Fourth, job satisfaction increases as the psychosocial function among mentoring functions is strengthened in a situation where the working period is controlled. Fifth, job satisfaction increases as the role model function among mentoring functions is strengthened in a situation where the working period is controlled.
Conclusions Due to the role of individual employees of resort companies, the role model function and the guidance function were added among the career development functions, which had the greatest effect on job satisfaction. In other words, rather than relying on the mentoring relationship, it can be seen that the behavior, way of thinking, disposition, attitude, job ability, qualifications, and values of individual workers in senior roles actually affect the mentee's job satisfaction improvement. Therefore, one-on-one mentoring programs between seniors and juniors within the organization should be actively introduced to encourage individual job competency reinforcement and self-development, so that organizational adaptability and continuous learning ability can be improved. In addition, in order to further activate the role model function, it will be necessary to appoint an excellent senior or role model for each job as a mentor, or to seek a way to foster excellent mentors.
Differences in Learning Engagement Depending on Need for Cognition and the Effect of Need for Cognition on Cognitive Competency through Self-Directed Learning Process among College Students
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Jang Nayoung
Published: September 2022

Objectives The purpose of this study was first to explore whether high/low need for cognition groups differ in the level of learning engagement, and second to examine the effect of the need for cognition on cognitive competency development through the self-directed learning process.
Methods Using the data of 1,110 students in four-year colleges from the 9th-year (2014) Korean Education Longitudinal Study 2005, independent sample t-tests and three-step linear regression analysis suggested by Baron and Kenny (1986) were conducted.
Results First, t-tests found that students with a high need for cognition showed higher mean scores for the self-directed learning process, classroom engagement, reading books, taking classes, and studying than those with low need for cognition. Second, after controlling for a variety of control variables, the higher need for cognition predicted a higher self-directed learning process and higher cognitive competency development. In addition, the self-directed learning process was found to have a partial mediation effect on the relationship between the need for cognition and cognitive competency.
Conclusions This study found the significant role that the need for cognition, which has received limited attention in higher education research, plays in learning engagement and in cognitive competency development through self-directed learning process. The results added empirical evidence to the individual-level predictors that are important for college student learning and cognitive competency development among college students.
An Ontological narrative Inquiry on Art Therapist’ Art Diary Experience
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Je Sukhee , Choi Sunnam
Published: September 2022

Objectives The purpose of this study is to understand what art therapists experience in the process of painting diary and what meaning those experiences have in the life of an art therapist.
Methods The inquiry method was an autobiographical inquiry, and among the qualitative research methods, the method of narrative inquiry was used. The research procedure was conducted from January 2021 to April 2022, and the analysis contents of the art therapist's analysis process and the researcher's flower drawings and diary writing were used as artifacts.
Results As a result of the investigation, the picture diary is a promise to the father, a pure record that connects the past and the present, and the image, that is, the flower painting, freed emotions and experiences. Also, although the analysis was painful, it became the basis for growth and healing, and the picture diary was a process of having time to immerse myself in my inner voice.
Conclusions This investigation was a courageous challenge for me as an art therapist to look back on my life through a picture diary, and it was a process of loving myself.
Effects of Design Play Program Using d.School Design Thinking Model on the Creativity of Early Childhood
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lee Jong-gil , An Yung-hea
Published: September 2022

Objectives This study aims to provide basic data for the field application of design play by verifying the effect on the creativity of infants and developing design play programs using the d.School design thinking model.
Methods To this end, a design play program was developed through related literature analysis, expert consultation, play draft development, and field suitability verification process, and pre-creativity and post-creativity tests were conducted to verify the effectiveness. Covariance analysis (ANCOVA) was performed for the collected data using the SPSS 19.0 Program.
Results First, the developed design play program is as follows. The goals of the program were to develop infants' empathy, develop infants' collaboration, develop infants' problem-solving skills, and develop infants' usefulness skills, and seven activities were selected in connection with the revised Nuri course's life theme. The teaching and learning method was reorganized into six stages, and the evaluation consisted of a formal evaluation of problem-solving ability, expression ability, and attitude as a process-based evaluation and an informal evaluation of infants' language expression, design play results, usefulness. Second, as a result of pre- and post-creativity tests, design play programs were found to have a positive effect on improving children's creativity, and among the sub-elements of creativity, there was a positive effect on the abstraction and sophistication of the title.
Conclusions This study is meaningful in that it suggested the possibility of field application of design play programs using design thinking models through development of design play programs and verification of creativity effects at a time when learning and play support through children's voluntary play is emphasized.
Analysis of Bettelheim's Psychoanalysis Using Traditional Fairy Tale
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Oh Eun Soon , Ahn Mee In
Published: September 2022

Objectives The purpose of this study is to examine Bettelheim's psychoanalytic interpretation of using traditional fairy tales as a psychotherapeutic tool for children with emotional disorders.
Methods A literature review was conducted focusing on Bettelheim's literature and related studies. Conclusions were drawn based on the contents of the study focusing on Bettelheim's life, the relationship between fairy tales and children, and Bettelheim's psychoanalytic interpretation.
Results It was found that fairy tales are effective as a psychiatric treatment medium along with a literary function through Bettelheim's psychoanalytic interpretation study. Therefore, it is necessary to try cooperative research between teachers in early childhood education and medical staff in the field of psychiatry to solve children's problems as a whole.
Conclusions Since the field of fairy tales has been expanded by Bettelheim, it is necessary to continue various studies on the value of fairy tales.
Effects of Mothers’ Emotional Expressiveness on Young children’s Resilience: Mediated by Fathers’ Parenting Involvement
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Ju Si-yeon , Kim Kyung Sook
Published: September 2022

Objectives This study was conducted to examine the mediating effect of fathers’ parenting involvement on the effects of mothers’ emotional expressiveness on young children’s resilience.
Methods For this study, it examined 269 five-year-old iyoung children enrolled in a child care centers located at J-do. young children’s resilience was evaluated by their teachers in charge of them and their mothers and fathers evaluated mothers’ emotional expressiveness and fathers’ parenting involvement in each home. The Pearson correlation analysis and Baron and Kenny’s three-step mediated regression analysis on the data collected were conducted by using SPSS WIN21.0, and then, the Sobel test of them was implemented.
Results The findings are as follows: First, there were significant correlational relationships among mothers’ emotional expressiveness, young children’s resilience, and fathers’ parenting involvement. Second, mothers’ emotional expressiveness had positive effects on young children’s resilience and the effect of mothers’ emotional expressiveness on young children’s resilience was mediated by fathers’ parenting involvement.
Conclusions The results of this study suggests that it is possible to more reliably understand the effects of mothers’ emotional expressiveness on iyoung children’s resilience, by considering fathers’ parenting involvement together and to enhance young children’s resilience based on variables in homes.
The effect of professor’s emotional leadership, the professor trust and the class concentration on the campus-life satisfaction among university students
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Hey Kyoung
Published: September 2022

Objectives The purpose of this study was to investigate the effect on the campus-life satisfaction by the professor’s emotional leadership, the professor trust and the class concentration.
Methods A survey was held to the university students living in Seoul and Chungcheong cities from June 10 to 21, 2021. 196 copies were in the final analysis for data analysis, Pearson’s Correlation Coefficient and hierarchical regressions was used.
Results As a result, the professor’s emotional leadership, the professor trust and the class concentration in university students all showed significant positive correlations with one another. accounted for 41.6% of the total variance in the campus-life satisfaction among university students.
Conclusions Therefore, this study could be used as a basic data for the counseling and developing and activation education programs to increase satisfaction with campus-life, to promote interaction with professors and to immerse in the class.
Exploring the Direction of Early Childhood Parent Education through Theory and Research Trends
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Min Hee
Published: September 2022

Objectives This study aims to present guidelines for parent education through the exploration of theories, programs, and research trends.
Methods The theories and programs related to the education of parents of young children were reviewed, and a total of 143 domestic journals were analyzed.
Results Results Five theories and four programs related to parent education were compared and analyzed, and the results of analysis of trends in domestic academic journals related to parent education were presented by research period, research method, and research topic. 1) Research on education of parents of young children has continued to increase since 2000. 2) In terms of research methods, quantitative studies were mainly conducted, and investigatory research studies and program development studies were the most frequent. In the second phase, qualitative research increased markedly. 3) In terms of themes, during the first phase, many studies were conducted in relation to parent education programs, whereas during the second phase, many studies were conducted in relation to the social aspects of parent education.
Conclusions The direction of education proposed for parents of young children derived through the exploration of parent education theories, programs and research trends is the strengthening of each of the following: expert-parent cooperative parent education; diversification of parent education according to changes in family form; parent education focused on young children of a future society; sustainable development parent education; reinforcement of preliminary parental education. In addition, a practical alternative to early childhood institution- centered parental education was suggested. The results of this study is intended to provide direction for future research on parent education, provide practical guidelines for parent education in early childhood education institutions, give policy direction in the education of parents of young children, and serve as the impetus for finding a solution for the low fertility rate problem.
Comparing Learners’ Perception Gap on PBL Applied ‘Global Citizenship Course’
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lee Eunjin
Published: September 2022

Objectives This study intends to investigate the perception gap on problem based learning (PBL) applied global citizenship course. Specifically, it compares two groups of learners with different majors, health science and engineering.
Methods For analysis, Q-methodology was employed, which is useful for exploring people’s subjectivity on a specific subject. Particularly, this method was useful in this research for analyzing and comparing how different or similar perspectives learners had on PBL applied global citizenship course, and further being able to provide deeper insights into the future PBL applied class.
Results The total of 30 statements was selected and 54 respondents, 27 in each group, participating in the PBL applied global citizenship course at K University, expressed their perspectives on the statements. Based on the results of the factor analysis using PQ-Method, three distinctive types in each group appeared to be significant: ‘Teamwork & Learning Materials Centered,’ ‘Motivation & Interest Centered,’ and ‘Confidence & Teamwork Centered’ in the group A; ‘Learning Materials & Textbook Centered,’ ‘Familiarity & Learning Process Centered,’ and ‘Familiarity & Individual Task Centered’ in the group B. Even though there is no statement both groups agreed or disagreed with, considering the distinctive types from the results and important points to be considered in PBL applied global citizenship course, there were implications: motivation or confidence, teamwork and learning materials.
Conclusions The findings of this research can be meaningful in identifying different attitudes towards PBL applied global citizenship class. Furthermore, it can contribute to providing right directions for the future PBL applied global citizenship course.
Adult Attachment and Employment-Preparation Behavior of College Students: Sequential Mediating Effects of Self-Soothing Ability, Intolerance of Uncertainty, and Job-Seeking Anxiety
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Park Yeo Sim , An Ha Yan
Published: September 2022

Objectives In this study, researchers established a major relational environmental factor and personal internal factors predicted to affect job-seeking anxiety. The purpose of this study is to examine the sequential mediating effects of personal internal factors (self-soothing ability, intolerance of uncertainty) in the process that a relational environmental factor (insecure adult attachment) affects employment-preparation behavior through job-seeking anxiety.
Methods For this study, a survey was conducted online. The data were collected from 301 college students who are juniors or seniors at a four-year college in 14 regions across the country. The participants in this survey were 137 male students (45.5%) and 164 female students (54.5%). Among these participants, college students preparing for employment were 251 (83%). The collected data were analyzed using SPSS 21 and R program Package ‘boot’.
Results As a result of the study, it was found that the higher the job-seeking anxiety, the higher the employment-preparation behavior. Through the additional analysis, it was confirmed that the employment-preparation behavior may appear differently based on the critical point of the job-seeking anxiety level. Next, the mediating effect of insecure adult attachment going to employment-preparation behavior through only job-seeking anxiety was not significant, but the mediating effect of sequentially going through two mediator variables, ‘self-soothing ability & job-seeking anxiety’, was significant. In the case of ‘intolerance of uncertainty & job-seeking anxiety’, the analysis conditions for the mediated model were not satisfied. However, in the influence of insecure adult attachment on employment-preparation behavior, it was found that the triple-mediated effect of ‘self-soothing ability, intolerance of uncertainty, and job-seeking anxiety’ was significant. It was confirmed that between two individual internal factors, self-soothing ability acted as a leading factor.
Conclusions This study verified the model integrally considering a relational environmental factor and individual internal factors that can have a major impact on job-seeking anxiety and employment-preparation behavior. According to this study, researchers identified the specific areas that can be provided or intervened in counseling and education. Based on the result of this study, it presented the significance, implications of the study, and suggestion about the follow-up research.
Exploring the meaning of identity formation through the experiences of preliminary early childhood teachers
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Chung Daeryun , Choi Sooyeon
Published: September 2022

Objectives This study investigated the meaning of identity formation as early childhood teachers through the experiences of preliminary early childhood teachers.
Methods Six preliminary early childhood teachers enrolled at universities located in Seoul and Gyeonggi-province were selected as research participants, and in-depth interviews were conducted to understand their experiences without exaggeration. Based thereon, Giorgi's “existential phenomenological analysis” was used to understand the meaning of lived experiences of preliminary early childhood teachers more concretely and reveal the meaning of it.
Results Preliminary early childhood teachers were forming their identity through: first, the memories of their own childhood and early childhood teachers, second, self-esteem and values to pursue that are formed based on personal beliefs as early childhood teachers, and third, the experiences of learning and practice encountered during the preparation process of becoming preliminary early childhood teachers.
Conclusions Time spent as preliminary early childhood teachers is important in order to form a positive early childhood teacher identity. In addition, it is necessary to provide various opportunities for teachers to talk to each other about the image and meaning of early childhood teachers from their own experiences. Furthermore, it is important to enhance the understanding of the field by strengthening practical training. It is also necessary to bring them to a sense of conviction that they are professionals by striving to improve the low social awareness on early childhood teachers, improving the working environment, and providing appropriate salaries.
Competitive ability of sweet sorghum (Sorghum bicolor (L.) Moench) cultivars against hairy beggarticks (Bidens pilosa L.)
Authors: Galon Leandro , Santin Carlos Orestes , Radünz André Luiz , Andres André , Concenço Germani , Da Silva Alexandre Ferreira , Nonemacher Felipe , Perin Gismael Francisco , Aspiazú Ignácio
Published: September 2022

Among the weeds that interfere with the growth and development of sweet sorghum, beggar ticks stands out, because it has a high competitive capacity for the available resources. This study aims to compare the competitive ability of sweet sorghum (Sorghum bicolor (L.) Moench) against hairy beggarticks (Bidens pilosa L.), as a function of cultivar and plant proportion. Experiments were conducted in a greenhouse in a completely randomized design with four replications and six treatments. Treatments were arranged in replacement series in the proportions of 100:0, 75:25, 50:50, 25:75, and 0:100% (sorghum:weed) equivalent to 20:0, 15:5, 10:10, 5:15 and 0:20 plants per pot with 8 dm3 capacity of sweet sorghum (cultivars ‘BRS 506’, ‘BRS 509’ or ‘BRS 511’) against hairy beggarticks. Fifty days after emergence, plant leaf area (LA), aboveground dry mass (DM), photosynthesis (A), and transpiration rates (E) were measured. Competitive ability was analyzed by using the graphical analysis method and building diagrams based on total and relative productivity. Competitiveness, clustering coefficient, and aggressiveness were also determined. Sorghum cultivars, in general, showed losses independently of the proportion of hairy beggarticks. Statistical analysis showed small differences in competitive ability among sorghum cultivars; ‘BRS 509’ was also demonstrated to be slightly more competitive than ‘BRS 506’ and ‘BRS 511’ against hairy beggarticks. This, however, is unlikely to provide a competitive advantage for ‘BRS 509’ in production fields, and hairy beggarticks should be efficiently controlled early in the crop cycle to avoid productivity losses, independently of the sorghum cultivar.
INNOVATIVE DRUG DELIVERY SYSTEMS FOR INFECTIOUS DISEASES OF THE SKIN
Authors: Türkmen Ayyüce , Esentürk-Güzel İmren , Kara Bilge Ahsen
Published: September 2022

Introduction: Skin is the organ of the body that is exposed mostly to the microorganisms. Bacteria, fungi, and viruses are usually responsible for the infection of the skin. Due to lack of penetration through the stratum corneum of conventional systems used in infectious diseases of the skin leads to a decrease in bioavailability. For this reason, nanoscale drug delivery systems that could be used in infectious diseases of the skin are currently being investigated.
Areas covered: In this review, innovative studies conducted over the years are presented. New topical formulations such as nanoparticles, microemulsions, liposomes, nanofibers and micelles etc are widely used and topic of research for many researchers.
Conclusion:  Studies have shown that the smaller size and control of these delivery systems provide more effective treatment by increasing drug penetration into the skin. It has been found that drug delivery systems provide a better antimicrobial effect, especially in resistant infections caused by MRSA.
Keywords: drug delivery systems, modified release dosage forms, skin infectious diseases, topical.
                      
Peer Review History:
Received: 17 July 2022; Revised: 16 August; Accepted: 4 September, Available online: 15 September 2022
Academic Editor: Dr. Rola Jadallah, Arab American University, Palestine, rola@aauj.edu
UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. 
Received file:                                Reviewer's Comments:
Average Peer review marks at initial stage: 5.0/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Prof. Dr. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, shmahe@yemen.net.ye
Dr. Nuray Arı, Ankara University, Turkiye, ari@ankara.edu.tr
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Non-trivial symmetries in quantum landscapes and their resilience to quantum noise
Authors: Fontana Enrico , Cerezo M. , Arrasmith Andrew , Rungger Ivan , Coles Patrick J.
Published: September 2022

Very little is known about the cost landscape for parametrized Quantum Circuits (PQCs). Nevertheless, PQCs are employed in Quantum Neural Networks and Variational Quantum Algorithms, which may allow for near-term quantum advantage. Such applications require good optimizers to train PQCs. Recent works have focused on quantum-aware optimizers specifically tailored for PQCs. However, ignorance of the cost landscape could hinder progress towards such optimizers. In this work, we analytically prove two results for PQCs: (1) We find an exponentially large symmetry in PQCs, yielding an exponentially large degeneracy of the minima in the cost landscape. Alternatively, this can be cast as an exponential reduction in the volume of relevant hyperparameter space. (2) We study the resilience of the symmetries under noise, and show that while it is conserved under unital noise, non-unital channels can break these symmetries and lift the degeneracy of minima, leading to multiple new local minima. Based on these results, we introduce an optimization method called Symmetry-based Minima Hopping (SYMH), which exploits the underlying symmetries in PQCs. Our numerical simulations show that SYMH improves the overall optimizer performance in the presence of non-unital noise at a level comparable to current hardware. Overall, this work derives large-scale circuit symmetries from local gate transformations, and uses them to construct a noise-aware optimization method.
Existential migration during the pandemic in Latvia: insight into solutions at the intersection of religious science and human geography
Authors:   University of Latvia, Kiope Mara
Published: September 2022

Recent research trends related to the understanding of the meaning of philosophy and its use in interdisciplinary research in human geography. Therefore, the article aims to demonstrate a pilot model of an innovative methodology that forms the interface between human geography and philosophy. The terms “home experience” and “existential migration”, conceptualized by psychotherapist and philosopher Greg Madison, have been used to summarize interviews with migrants who have voluntarily chosen to integrate into another country, society, and culture in order to find a place to live in harmony with their individual being. Research on authenticity of life as a motive for migration has not developed so far, but it makes it possible to link the analysis of human experience, which is the focus of phenomenology, with empirical data sources. The mediation of human geography findings and axiological theory ensures that concepts of a philosophical nature form the architecture of a unified system of knowledge, in which empirical data are organically incorporated. In this case, they are the data from the many large-scale studies conducted in Latvia on the impact of the Covid-19 pandemic, particularly of the lockdown, on the population of Latvia. They all form a single text, which is examined by qualitative content analysis and cohort methods, revealing the nature of interpersonal relations in Latvian society, which are important in solving migration issues.
The impact of outdoor signage on the streetscapes of Old Riga
Authors:   University of Latvia, Kuceruka Alisa , Peneze Zanda ,   University of Latvia
Published: September 2022

Visual pollution caused by insufficiently considered usage of outdoor signage in urban areas can negatively influence the visual quality of public outdoor space. Like other urban areas, Riga is exposed to the risk of this type of visual pollution. As Old Riga is included on the UNESCO World Heritage List, it is important to keep it clean from such contamination. So far, no in-depth research on visual pollution in Old Riga has been carried out. Therefore, the aim of our study was to explore and assess the occurrence and impact of outdoor signage in the main shopping streetscapes of Old Riga. The study was based on spatial preference and observation, street colour photomontages, on sociological investigation methods and on analysis of regulatory and planning documents. The studies showed that the existing outdoor signage on the facades of the buildings of Old Riga causes visual pollution, which, in its turn, negatively affects the appearance of historical monuments and buildings and lowers the visual quality of public outdoor space. The development of appropriate design guidelines or a design code containing specifications for outdoor signage, windows, facades and their elements and design would promote the development of aesthetically consistent, expressive and high-quality urban space.
Situation of common ash (Fraxinus excelsior) in Latvia of the active phase of forest destruction. Forest stand dynamics and distribution in the last 80 years (1940 2020)
Authors:   Latvian State Forest Research Institute ", Laivins Maris ,   Silava", Krampis Ilmars ,   Latvian State Forest Research Institute "Silava", Snepsts Guntars ,   Latvian State Forest Research Institute "Silava"
Published: September 2022

At the beginning of the 19th century, common ash was a rare species in the forests of Latvia. Back then, the first ash plantations were cultivated in Western Latvia (Cīrava), but the attempt was not successful. After that, the ash spread gradually, with a particularly sharp increase during the second half of the 20th century. In 58 years (1940-1998), as a result of intensive natural regeneration and planting efforts, the area of ash stands in forests increased 9.2 times, reaching 0.79% of the forest area, a large proportion of which (62%) was covered by young stands (up to 40 years old). In the first twenty years (2001-2020) of the 21st century, with the onset of the pandemic of fungal pathogen Hymenoscyphus fraxineus, the area of ash stands has decreased 1.9 times. During the pandemic, ash young stands and pure ash stands have suffered the greatest loss. Therefore, when growing future ash stands, it is necessary to maintain a balanced age structure of stands and to create ash mixed stands.
Minority groups in the largest cities of Latvia
Authors:   University of Latvia, Berzins Maris , Spude Magnuss ,   University of Latvia
Published: September 2022

Spatial segregation of minority ethnic groups is a returning issue in public and political debates across many parts of the world. The degree of spatial concentration and segregation of ethnic minorities in European cities is well documented. However, despite Latvia's diverse migration history and relatively high minority population, particularly in the largest cities, these issues have received scant attention. This study examines the residential patterns of minority ethnic groups, presenting data on the levels and dynamics of urban residential segregation. The study includes five ethnic minorities: Russians, Belarusians, Ukrainians, Poles, and other ethnicities. We adopted a widely used methodology to examine changes in ethnic residential segregation between 2000 and 2019. The information comes from the 2000 census and the population register. We are confident in stating that overall ethnic residential segregation levels do not appear to be increasing. However, there are some differences not only between ethnic groups in the same city, but also between similar groups in different cities. Furthermore, demographic change reinforces both minority representation in established residential patterns and ethnic segregation in urban Latvia as a whole. Certain characteristics of the Latvian context, such as the dominance of owner-occupied dwellings and relatively low residential mobility, may explain the findings.
Trends and prospects of cartographic production development in Russia and abroad
Authors: Vereschaka T.V. , Orlov M.Yu.
Published: September 2022

The authors substantiate the relevance of cartographic production study in Russia, its dynamics and development trends in the view of further improvement. Conceptual and methodological approaches to the research are given, based on examining political, economic, scientific and technical factors of influence in terms of quantitative indicators and those of progressive development and regression, as well as on the construction of an integral graphical model of impacts. The features of the cartographic production functioning are characterized, covering international experience in the period from 2017 to the present, the typical of which will inevitably affect the next stage. The dynamics of world exports and imports of cartographic products of the main world manufacturers (state and commercial) for types of cartographic products is shown. Recommendations for improving production based on the analysis of problems and development trends are proposed.
Covid-19, marginalidad y pobreza: El desafío fundamental
Authors: Vargas Solís Luis Paulino
Published: September 2022

Este escrito forma parte de una serie de documentos elaborados por investigadoras e investigadores del Centro de Investigación en Cultura y Desarrollo de la UNED, donde a manera de ensayo se presentan análisis y reflexiones sobre el cómo diversos aspectos de nuestra realidad cotidiana se han visto afectados a partir de la aparición del COVID-19.
Juventud: entre la reproducción, el diálogo y la confrontación/conflicto con el mundo adulto
Authors: González Sancho Roy
Published: September 2022

Para este artículo, se pretende presentar un primer acercamiento a la compresión de la juventud como una estructura relacional que se construye desde tres principios pilares, a saber: la reproducción, el diálogo y la confrontación o el conflicto con lo adulto; mediante un ensayo científico, llevado a cabo desde un enfoque cualitativo y con un alcance interpretativo. De esta forma, se discute sobre varias de las configuraciones que conceptos como la juventud, lejos de limitarse a describir un proceso de oposición a todo aquello cuanto refiera al mundo de lo adulto o de responder a sus estereotipos, expresa en su dinámica la composición de la sociedad y momento histórico en el que se desempeña.
Synthesis and Anti Proliferative Activity of Thiosemicarbazone and 4-Thiazolidinones
Authors: Gupta Monika
Published: September 2022

Thiosemicarbazone and 4-Thiazolidinones are heterocyclic compounds with a broad spectrum of biological activities such as anti-inflammatory, anti-viral, anti-bacterial, anti-fungal and anticancer. A series of ten derivatives of thiosemicarbazone and 4-thiazolidinones derivatives was synthesised and evaluated for their antiproliferative activity against human breast cancer cells (MCF-7). The structure of compounds was established by IR and 1HNMR spectral studies. The synthesized compounds possessed good to moderate anticancer activity using Adriamycin as a standard. Out of ten synthesized compounds eight have GI50 value of <10 µg/ml demonstrating their potential activity. TGI for compound 6d was found to be comparable to Adriamycin (<10 µg/ml).
Antioxidant and Antiseptic Properties of Volatile Oils from Different Medicinal Plants: A Review
Authors: Tiţa Ovidiu
Published: September 2022

The use of preservatives is increasingly common in the food industry. The extension of the term of validity of the food products, as well as the preservation of their appearance for a longer period, is an increasingly common condition among food processors. Unfortunately, most synthetic preservatives are used, omitting the use of natural preservatives. The antiseptic potential of essential oils from different medicinal plants may be a natural alternative to the synthetic preservatives used. The daily stress that surrounds us produces in the human body a significant amount of free radicals that over time affect our health. To eliminate these free radicals we need antioxidants from the outside. A very good variant of consumption of these antioxidants is directly through the food we consume. Medicinal plants have a high content of antioxidants, and their use in our diet as volatile oils can be a solution. This review includes published articles on the antioxidant and antiseptic properties of essential oils from different medicinal plants. We classified the plants according to their properties and highlighted the most important compounds that they have.
Can definite integral solve the 'aul problem?
Authors: Musthofa Muhammad Wakhid , Malahayati Malahayati
Published: September 2022

There is a similarity in concept between 'aul and the definite integral. 'Aul deals with the issue of the quantity of inheritance which must be divided into smaller quantities in order to be handed over to the heirs, while definite integral relates to the problem of calculating the broad of an area by dividing the area into smaller ones, followed by summing up the broad of each area. Achmad Yani used the definite integral to solve the problem of 'aul. But, in our opinion, the concept he used was wrong and there were still some errors in the construction that he described. This article aims to provide some corrections to such errors and provide some notes that as far as our research, the definite integral has not been able to be used in solving the problem of 'aul yet.