bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of a novel synthetic nanofibre matrix to treat hard-to-heal wounds
Authors: Herron Karena
Published: November 2022

Objective:

Complex hard-to-heal wounds are difficult to manage, generating significant expense to the US healthcare system, costing nearly $25 billion annually. Recently, a resorbable synthetic nanofibre matrix was trialled on a variety of complex hard-to-heal wounds at Astria Sunnyside Hospital to assess clinical efficacy.

Method:

In this case series, five patients with multiple comorbidities presented in both the inpatient and outpatient setting with various hard-to-heal refractory wounds, including a venous leg ulcer (n=1), a diabetic foot ulcer (n=1), a Charcot foot deformity (n=1) and pressure ulcers (n=2). In an effort to treat these hard-to-heal wounds using a different treatment modality, each patient was transitioned to a care regimen utilising the synthetic nanofibre matrix.

Results:

Each patient, regardless of wound type, exhibited the formation of granulation tissue and a reduction in wound size. The application of this synthetic nanofibre matrix also resulted in tissue coverage over exposed structure in three cases, reduction of wound exudate in two cases, and eliminated a recurring infection with and without antibiotics in four cases.

Conclusion:

In this study, the treatment of hard-to-heal refractory wounds with the synthetic nanofibre matrix resulted in the desired biological responses and new tissue formation. Inclusion of the nanofibre matrix in inpatient and outpatient wound care settings may provide a much-needed solution for costly, difficult-to-treat, hard-to-heal wounds, and may offer a reduction in the total cost of care.
For My Teacher, Walterio Carbonell
Authors: Robaina Tomás Fernández
Published: November 2022

This essay is dedicated to Walterio Carbonell (1920-2008), the controversial Afro-Cuban Marxist thinker, on the 50th year of the publication of his masterpiece Como Surgió la Cultura Nacional (“On The Emergence of National Culture”). It was published in a 1961, a year marked by the official declaration of the socialist character of the Cuban Revolution, the victory of Playa Girón (the “Bay of Pigs”), and the launching of a massive literacy campaign. Carbonnell’s text confronts the traditional version of Cuban history, which assigns the leading role of the gestation of Cuban nationality to an enlightened aristocracy of White Creoles of Spanish origin. According to this version, such intellectual groups generated an ideology of independence that led to the beginning of the anti-colonial wars against Spain in 1868. Today, this explanation, with slight modifications, continues to be the most widespread in Cuba.
Groundings in Cuba
Authors: Guerra Zuleica Romay
Published: November 2022

This brief essay places Rodney in the context of the development of trans-Atlantic African Diaspora consciousness and culture, and the development of non-Western contingent Marxist theories from dependency to his underdevelopment thesis. Rodney’s biography and intellectual development are contextualized in their Caribbean, Latin American and Diasporic Black contexts, and in the context of Rodney’s engagement with people, pedagogy and political processes in Jamaica, Tanzania, London and Guyana. Specifics of his Cuban sojourns and evolving conceptions of the revolution, his work on a book while there, and his placement within Cuban research and broader Caribbean and Latin American tendencies are examined.
Colibactin possessing E. coli isolates in association with colorectal cancer and their genetic diversity among Pakistani population
Authors: Tariq Habiba , Noreen Zobia , Ahmad Aftab , Khan Laraib , Ali Mashhood , Malik Muhammad , Javed Aneela , Rasheed Faisal , Fatima Alina , Kocagoz Tanil , Sezerman Ugur , Bokhari Habib
Published: November 2022

Colorectal cancer (CRC) is the third most prevalent cause of tumorigenesis and several pathogenic bacteria have been correlated with aggressive cases of cancer i.e., genotoxin (colibactin) producing Escherichia coli (E. coli). This study was designed to investigate the genetic diversity of clb+clb+ E. coli strains and their association with CRC. Pathogenic E. coli isolates from colorectal biopsies were characterized based on phylotypes, antibiotic resistance pattern, and (Enterobacterial Repetitive Intergenic Consensus Sequence-based Polymerase Chain Reaction) ERIC-PCR. Furthermore, isolates were screened for the presence of the Pks (polyketide synthase) Island specifically targeting colibactin genes A and Q. The selective clb+clb+ isolates were subjected to cytotoxicity assay using Human embryonic kidney (HEK) cell lines. We revealed that 43.47% of the cancer-associated E. coli isolates were from phylogroup B2 comparatively more pathogenic than rest while in the case of healthy controls no isolate was found from B2. Moreover, 90% were found positive for colibactin and pks (polyketide synthase) island, while none of the healthy controls were found positive for colibactin genes. All healthy and cancer-associated isolates were tested against 15 antibiotic agents, we observed that cancer-associated isolates showed a wide range of resistance from 96% against Nalidixic acid to 48% against Doxycycline. Moreover, E. coli isolates were further genotyped using ERIC-PCR, and selected clb+clb+ E. coli isolates were subjected to cytotoxicity assay. We recorded the significant cytotoxic activity of clb+clb+ E. coli phylogroup B2 isolates that might have contributed towards the progression of CRC or dysbiosis of healthy gut microbiota protecting against CRC pathogenesis. Our results revealed a significant p<0.023 association of dietary habits and hygiene p<0.001with CRC. This is the first study to report the prevalence of E. coli phylogroups and the role of colibactin most virulent phylogroup B2 among Pakistani individuals from low socioeconomic setup.
What does it mean to be affiliated with care?: Delphi consensus on the definition of “unaffiliation” and “specialist” in sickle cell disease
Authors: Lamont Andrea E. , Hsu Lewis L. , Jacobs Sara , Gibson Robert , Treadwell Marsha , Chen Yumei , Lottenberg Richard , Axelrod Kathleen , Varughese Taniya , Melvin Cathy , Smith Sharon , Chukwudozie Ifeanyi Beverly , Kanter Julie ,   the Sickle Cell Disease Implementation Consortium
Published: November 2022

Accruing evidence reveals best practices for how to help individuals living with Sickle Cell Disease (SCD); yet, the implementation of these evidence-based practices in healthcare settings is lacking. The Sickle Cell Disease Implementation Consortium (SCDIC) is a national consortium that uses implementation science to identify and address barriers to care in SCD. The SCDIC seeks to understand how and why patients become unaffiliated from care and determine strategies to identify and connect patients to care. A challenge, however, is the lack of agreed-upon definition for what it means to be unaffiliated and what it means to be a “SCD expert provider”. In this study, we conducted a Delphi process to obtain expert consensus on what it means to be an “unaffiliated patient” with SCD and to define an “SCD specialist,” as no standard definition is available. Twenty-eight SCD experts participated in three rounds of questions. Consensus was defined as 80% or more of respondents agreeing. Experts reached consensus that an individual with SCD who is unaffiliated from care is “someone who has not been seen by a sickle cell specialist in at least a year.” A sickle cell specialist was defined as someone with knowledge and experience in SCD. Having “knowledge” means: being knowledgeable of the 2014 NIH Guidelines, “Evidence-Based Management of SCD”, trained in hydroxyurea management and transfusions, trained on screening for organ damage in SCD, trained in pain management and on SCD emergencies, and is aware of psychosocial and cognitive issues in SCD. Experiences that are expected of a SCD specialist include experience working with SCD patients, mentored by a SCD specialist, regular attendance at SCD conferences, and obtains continuing medical education on SCD every 2 years.” The results have strong implications for future research, practice, and policy related to SCD by helping to lay a foundation for an new area of research (e.g., to identify subpopulations of unaffiliation and targeted interventions) and policies that support reaffiliation and increase accessibility to quality care.
The use of integrated text mining and protein-protein interaction approach to evaluate the effects of combined chemotherapeutic and chemopreventive agents in cancer therapy
Authors: Samandari Bahraseman Mohammad Rasoul , Khorsand Babak , Esmaeilzadeh-Salestani Keyvan , Sarhadi Solmaz , Hatami Nima , Khaleghdoust Banafsheh , Loit Evelin
Published: November 2022

Combining chemotherapeutic (CT) and chemopreventive (CP) agents for cancer treatment is controversial, and the issue has not yet been conclusively resolved. In this study, by integrating text mining and protein-protein interaction (PPI), the combined effects of these two kinds of agents in cancer treatment were investigated. First, text mining was performed by the Pathway Studio database to study the effects of various agents (CP and CT) on cancer-related processes. Then, each group’s most important hub genes were obtained by calculating different centralities. Finally, the results of in silico analysis were validated by examining the combined effects of hesperetin (Hst) and vincristine (VCR) on MCF-7 cells. In general, the results of the in silico analysis revealed that the combination of these two kinds of agents could be useful for treating cancer. However, the PPI analysis revealed that there were a few important proteins that could be targeted for intelligent therapy while giving treatment with these agents. In vitro experiments confirmed the results of the in silico analysis. Also, Hst and VCR had good harmony in modulating the hub genes obtained from the in silico analysis and inducing apoptosis in the MCF-7 cell line.
A classification of specific movement skills and patterns during sprinting in English Premier League soccer
Authors: Caldbeck Paul , Dos’Santos Thomas
Published: November 2022

The aim of this study was to quantify and contextualize sprinting actions (≥ 7.0 m/s) of English Premier League (EPL) soccer match-play with respect to the movement skills and patterns employed. Video footage (3.2.6, Premier League DVMS, ChyronHego) and raw video-based locomotor coordinates of 901 sprint efforts from 10 matches of an EPL soccer team (2017–2018), were evaluated using the Football Sprint Movement Classification System pertaining to transition, initiation, and actualisation of sprint movement skills and patterns. The results from a one-way ANOVA or independent t-test revealed that, generally, most sprinting actions begun from a linear initiation position compared to lateral or rear (63%,d =5.0–5.3,p< 0.01), without a change of direction (COD) (48%,d= 4.9–5.6,p< 0.01) compared to lateral, front-back, back-front, and from forward travelling (linear and diagonal) transition movements (68%,d= 2.1–5.7,p< 0.01) compared to lateral or rear. Additionally, most sprints were initiated with a rolling acceleration (66%,d= 3.2,p< 0.01) compared to explosive acceleration, often performed with a degree of curvature (86%,d= 7.2,p< 0.01) compared to linear, with torso rotation (62%,d= 2.7,p< 0.01) compared to no rotation, and typically end with an action such as duelling with an opponent or involvement with the ball (49%). Additionally, the sprint movement characteristics proportions slightly differed across playing positions. Overall, this study confirms that sprints during EPL soccer matches are initiated from and performed with a variety of different movement skills and patterns in relation to different sport-specific outcomes. This data can be used to assist in the development of more effective physical preparation programmes, inform position-specific contextualized sprinting drills to achieve better specificity and potential transfer of training, while also informing speed testing protocols.
Does the use of patient-specific instrumentation improve resource use in the operating room and outcome after total knee arthroplasty?–A multicenter study
Authors: Beyer Franziska , Lützner Cornelia , Stalp Michael , Köster Georg , Lützner Jörg
Published: November 2022

Patient-specific instrumentation (PSI) in total knee arthroplasty (TKA) has been introduced to reduce instruments and surgical time and to improve implant alignment. The aim of this study was to compare TKA with patient-specific and conventional instrumentation with regard to the use of resources in the operating room (OR), alignment and patient-reported outcome. A total of 139 TKA with PSI or conventional instrumentation were included in three centers. Economic variables of the surgery (number of instrument trays, setup and cut-sew-time), radiological alignment and patient reported outcomes (VAS Pain Scale, Oxford Knee Score, EQ-5D) were assessed after 6 weeks, 6 and 12 months. There was a significant reduction of instrument trays and of time in the OR in the PSI group. The reduction varied between the centers. With strict reorganization, more than 50% of the instrument trays could be reduced while using PSI. There were no significant differences in cut-sew-time, implant position, leg axis, pain and function. The use of PSI was associated with significantly less OR resources. However, the savings did not compensate the costs for this technology.
Healthcare resource use and costs related to surgical infections of tibial fractures in a Spanish cohort
Authors: Barrés-Carsí Mariano , Navarrete-Dualde Jorge , Quintana Plaza Javier , Escalona Elena , Muehlendyck Christian , Galvain Thibaut , Baeza José , Balfagón Antonio
Published: November 2022

Surgical site infection constitutes a serious complication in the healing process of bone fractures and has been associated with increases in medical resource use and healthcare costs. This study evaluates the economic impact of surgical site infection in tibial fractures in a Spanish cohort. It is a retrospective, single-centre, comparative cohort study of patients with tibial fractures with longitudinal follow-up for up to 18 months post-surgery. Included patients (n = 325) were adults, with tibial fracture, either isolated or polyfracture, or polytrauma with an Injury Severity Score >15. Patients had been surgically treated within 30 days of the tibial fracture by external or internal fixation, or external followed by internal fixation. Most patients (84.9%) had an American Society of Anaesthesiology score of 1–2. 20% of the patients had one open tibial fracture, 12.3% had polytrauma, and 20% had multiple fractures. Most patients were treated with a nail (41.8%) or a plate (33.8%). 56 patients (17.2%) developed surgical site infection. Patients with infection had significantly higher hospital length of stay (34.9 vs 12.0 days; p<0.001; +191%), readmissions (1.21 vs 0.25; p<0.001; +380%) and mean operating theatre time (499 vs 219 min; p<0.001; +128%) than patients without infection. Mean length of stay in intensive care did not significantly increase with infection (2.8 vs 1.7 days; p = 0.25). Total in-hospital costs for patients with infection increased from €7,607 to €17,538 (p<0.001; +131%). Overall, infections were associated with significantly increased healthcare resource use and costs. Preventive strategies to avoid infections could lead to substantial cost savings.
Effects of the poultry red mite (Dermanyssus gallinae) load on the plumage condition in commercial laying hen farms
Authors: Schreiter Ruben , Herzog Marion , Freick Markus
Published: November 2022

Plumage damage (PD) resulting from severe feather pecking (SFP) is a significant problem for animal welfare, performance, and economics in commercial laying hen farms. Genetics, nutrition, and housing conditions are central complexes that contribute to the multifactorial cause of SFP. Practical experience suggests that infestation by the poultry red mite (PRM), which is the most severe ectoparasite of laying hens in cage-free housing systems, may be a risk factor for the occurrence of PD, although evidence-based findings are lacking. The objective of this longitudinal observational field study was to investigate the effects of PRM infestation of commercial laying flocks on the occurrence of PD. Integument scoring (plumage damage and skin lesions) and the quantification of PRM infestation using mite traps were conducted during the laying period of 28 laying flocks, with an average flock size of 12,357 birds in barn (n = 21) or free-range (n = 7) systems. Across all flocks and survey times, the median PRM mass per trap was 0.7 mg (1.-3. quartile: 0.0–19.3 mg/trap), corresponding to a median count of 65.2 mites/trap (1.-3. quartile: 0.0–246.8 mites/trap). Binary logistic regression models revealed an association between PD and skin lesions with hen age, housing system, and hybrid type (p<0.001). The PRM load also affected the plumage condition, where PD increased with increasing PRM infestation (p<0.001). In addition, the PRM load tended to have an effect on skin injuries (p = 0.097). In conclusion, this longitudinal study identified the PRM load in laying hen flocks as a risk factor for PD.
Role of platelet indices as diagnostic and predictive biomarkers for comorbidity of diabetes and metabolic syndrome in southern Ethiopia: A comparative cross-sectional study
Authors: Haile Kassahun , Kedir Rebie , Timerga Abebe , Mose Ayenew , Arkew Mesay
Published: November 2022

Background

Metabolic syndromes (MetS) and diabetes mellitus (DM) comorbidity is a growing major global public health problem with huge morbidity and mortality. It is a pro-inflammatory and prothrombotic disorder characterized by alteration of platelet indices and increased platelet activation, however, the tendency to use them in diagnosis is not yet fully evaluated in our context and there is limited evidence on the role of platelet indices in predicting and differentiating DM+MetS comorbidity in Ethiopia. Thus, this study aimed to evaluate platelet indices in HC, DM, and DM+MetS, and to determine their role in the prediction of DM+MetS comorbidity risk and the distinction between DM+MetS and DM or healthy persons in southwest Ethiopia.

Method and materials

A comparative cross-sectional study was conducted in Wolkite University specialized hospital from March to August 2021. A total of 336 study participants (112 healthy controls (HC), 112 DM, 112 DM+MetS) was included in this study. Anthropmetric data were measured and the venous blood sample was collected to determine platelet indices, lipid profiles, and blood glucose levels. The SPSS version 21 statistical software was used to perform receiver operating curve (ROC), one-way ANOVA, and independent T-test analysis. The p-value for statistical significance was set at <0.05.

Result

In the present study, we found a significant difference in the mean value of PLT, MPV, and PDW between DM+MetS, DM, and HC. A statistically significant difference in the mean value of MPV and PDW was observed between HC and DM+MetS as well as DM and DM+MetS (p-value<0.001). At the cutoff value of 9.65fl with a sensitivity of 81.3% and a specificity of 67.9%, MPV differentiates DM+MetS from HC with an AUC of 0.859. MPV can differentiate DM+MetS from DM at a cutoff value of 10.05fl with sensitivity, specificity, and an AUC of 67.9%, 65.2%, and 0.675, respectively. At the cutoff value of 9.65fl with a sensitivity of 69.6% and a specificity of 67.9%, MPV differentiates DM from HC with an AUC of 0.747. The best platelet parameter identified in this study for predicting the presence of DM+MetS comorbidity was MPV (AUC=0.859; 95%CI=0.81-0.90).

Conclusion

In this study, a significant difference in the mean value of PLT, MPV, and PDW was found between DM+MetS, DM, and HC. The mean value of platelet indices showed significant increases in DM+MetS patients in comparison to HC and DM. MPV has been identified as a good potential marker to predict DM+MetS comorbidity and to differentiate DM+MetS comorbidity from the HC or DM. Our results show that MPV could be a good hematological marker to differentiate DM+MetS comorbidity from the HC or DM, and may offer supportive information for early diagnosis, prevention, and control. Thus, the findings of this study should be taken into account for the prevention and control of DM+MetS comorbidity.
A combined imaging, deformation and registration methodology for predicting respirator fitting
Authors: Caggiari Silvia , Keenan Bethany , Bader Dan L. , Mavrogordato Mark N. , Rankin Kathryn , Evans Sam L. , Worsley Peter R.
Published: November 2022

N95/FFP3 respirators have been critical to protect healthcare workers and their patients from the transmission of COVID-19. However, these respirators are characterised by a limited range of size and geometry, which are often associated with fitting issues in particular sub-groups of gender and ethnicities. This study describes a novel methodology which combines magnetic resonance imaging (MRI) of a cohort of individuals (n = 8), with and without a respirator in-situ, and 3D registration algorithm which predicted the goodness of fit of the respirator. Sensitivity analysis was used to optimise a deformation value for the respirator-face interactions and corroborate with the soft tissue displacements estimated from the MRI images. An association between predicted respirator fitting and facial anthropometrics was then assessed for the cohort.
Introducción al dossier: Negacionismos, relativizaciones, banalizaciones, manipulaciones. Las nuevas derechas latinoamericanas y los usos del pasado reciente.
Authors: Lvovich Daniel , Patto Sá Motta Rodrigo
Published: November 2022

.
Banalización, relativización, negacionismo. Un escenario en los campos de batalla por la memoria del pasado argentino reciente
Authors: Lvovich Daniel , Grinchpun Matías
Published: November 2022

Si bien el concepto de negacionismo se empleó originalmente para denotar la negación del Holocausto, su uso pronto se diversificó: es así que en Argentina suele remitir a los discursos que pretenden refutar la existencia y ejecución de un plan represivo que, con antecedentes en los años de María Estela Martínez de Perón, fue desplegado durante la dictadura instaurada en 1976. De forma paralela a tales mecanismos, existe otro uso de la historia que puede llamarse relativización, la cual tiende a disminuir la gravedad del terrorismo de Estado al ubicarlo en una serie narrativa que lo normaliza y/o banaliza. En este trabajo analizaremos la implementación de estas estrategias por un amplio abanico de actores, contextualizándolas en las transformaciones de la historia política y cultural reciente para así dar cuenta, cuando fuera posible, de su eficacia.
Reseña del libro: “Qué digan donde están. Una historia de los derechos humanos en Argentina", de Luciano Alonso
Authors: Manduca Ramiro
Published: November 2022

El presente texto reseña el libro de Luciano Alonso "Qué digan donde están”. Una historia de los derechos humanos en Argentina. Se trata de una obra que plantea un abordaje basto a escala nacional, local y extra-territorial del origen y desarrollo del movimiento derechos humanos en Argentina en debate con algunas premisas fuertemente arraigadas en la academia y fuera de ella sobre este agente colectivo de enorme relevancia en la historia argentina reciente.
Por una poética planetaria en la formación de maestras y maestros de la Universidad de Antioquia
Authors: Moreno Torres Mónica
Published: November 2022

Esta reflexión está inspirada en mi experiencia como formadora de formadores durante veinte años y en la oportunidad que tuve de coordinar, por un año, la comisión encargada de la actualización del Proyecto Formativo del Programa (PFP) de la Licenciatura en Literatura y Lengua Castellana de la Facultad de Educación de la Universidad de Antioquia. Dichas vivencias, junto con las discusiones sostenidas en 2020 durante la primera actualización del PFP construido en 2013, suscitaron mi interés por la formación política de los maestros y las maestras. Por ello señalo la necesidad de una educación en espiral, cuyo movimiento responda tanto a reflexiones vitales por el derecho a la vida de los sujetos y la naturaleza como al estudio y generación de propuestas donde el desarrollo social, científico, cultural y estético estén al servicio de una economía del bien vivir y de una política de la existencia. Presento, además, un recorrido por los acontecimientos sociales, políticos y educativos trascendentales en los últimos ocho años en Colombia, que se han caracterizado por luchas sociales que evidencian un cansancio de ciertos sectores de la sociedad frente a la pérdida progresiva de valores que deberían, según esta reflexión, estar presentes desde la cuna hasta la tumba para todos y todas. Finalmente, me enfoco en la importancia de pensar la formación desde una poética planetaria que permita la construcción de un mundo otro
El taller de una costuromaestra cosiendo e investigando
Authors: Arroyave Salazar Elvia Adriana , Castro Carvajal Julia
Published: November 2022

Este artículo pretende mostrar la conversión de una profesora de español y literatura en costuromaestra junto a su asesora de Doctorado en Educación. Tras experimentar la relación entre costura y escritura como un modo de investigar para pensar de forma diferente a lo que se ha pensado, y percibir de forma diferente lo que se ha sentido y tejido en el cuerpo laberinto de ellas mismas y de los maestros como una forma de acercarse a las afecciones que subyacen y que muchas veces son sofocadas tras el exceso de productividad en el encuentro educativo. El artículo se fundamenta en nuevas formas de investigación en la formación de formadores, las cuales problematizan el método como una acción para entrelazar investigación e investigadoras, y experimentar lo que se puede cambiar, a través del extrañamiento de lo vivido y sentido en lugar de limitarse a consolidar lo que ya se sabe. En el curso de la investigación, la maestra que deviene en costuromaestra usa una caligrafía disruptiva desde el taller de costura para coser y descoser las afecciones en el mismo gesto como ejercicio para coser afecturas, experimentando, con los maestros, una escritura otra, que permita compartir y convertir con otros maestros las afecturas en aficciones para aumentar su potencia de relacionarse en el encuentro educativo y, por ende, en el poder de educar.
Found Foto-Film
Authors: Praetorius Charlotte
Published: November 2022

Analoge Fotografien begegnen uns im digitalen Zeitalter oft als Dinge, die – nachdem sie verwahrt, verloren oder sogar weggeworfen worden waren – (wieder-)gefunden werden. Die Faszination für solche gefundenen Fotos spiegelt sich auf markante Weise im zeitgenössischen Essay- und Dokumentarfilm wider. Found Foto-Filme sind eine seit der Jahrtausendwende neu entstandene essayistisch-dokumentarische Form: Filme, die mit hinterlassenen, geretteten oder gefundenen Konvoluten fotografischer Bilder arbeiten, diese sammeln, auswählen und in einen neuen Kontext stellen. Sie stehen in einem Spannungsfeld zwischen populärer Ästhetisierung und Re-Auratisierung analoger Medien im Zuge der Digitalisierung sowie einer langen Tradition, die Materialität und Medialität von Film durch die Arbeit mit Fotografie und Found Footage filmisch zu reflektieren. Charlotte Praetorius erkundet solche Aneignungen analoger Fotos anhand eines Korpus internationaler Filme: Wie setzen sich die Filmemacher_innen zu den fotografischen Funden ins Verhältnis? Wie greifen die Erzählungen und die Erzählbarkeit von Fotografie und Geschichte ineinander? Wie wird das fotografische Material angeordnet und inszeniert? Und wie lassen sich die Verhältnisse zwischen verschiedenen Medien und Materialien fassen? Dabei geht es Praetorius auch darum, die Formen des dokumentarischen und essayistischen Films als ein Reflexionsmedium von (Medien-)Geschichte ernst zu nehmen und zugleich auch kritisch infrage zu stellen.
Die globalistische Elite gegen das Volk. Antisemitismus und rechtspopulistisches Elitenbild
Authors: Roepert Leo
Published: November 2022

In the social sciences, it is often argued that in right-wing populism anti-Semitism does not play an important role and that cultural racism has taken over its function. In contrast, this article aims to show that right-wing populism reproduces anti-Semitic patterns in a codified form. First, it will be shown that problematic definitions and explanatory approaches are widespread in social science discourse, which contribute to the fact that the anti-Semitic content of right-wing populism is barely perceived. Subsequently, by analyzing two case studies – an essay by AfD politician Alexander Gauland and a speech by Donald Trump – it is shown that right-wing populist discourses asserting a struggle between the people and the »globalist elite« reproduce anti-Semitic patterns even though »Jews« are not explicitly mentioned. Finally, it is argued that this phenomenon can be grasped with the concept of structural anti-Semitism. With this term, it can be made clear that right-wing populism indeed has an anti-Semitic potential and that the contents and functions of anti-Semitism and racism must be distinguished.
Welfare Effects of Socially Conscious Platforms in Two-Sided Markets
Authors: Abe Hayama , Zennyo Yusuke
Published: November 2022

This note presents a model of platform competition in a two-sided market, with one competing platform pursuing not only its own profit but also consumer surplus. We investigate how the presence of such a socially conscious platform affects market competition. Results indicate that greater emphasis as an objective put on consumer surplus by the socially conscious platform leads to higher market share. Creation of a larger network enhances the total benefits associated with indirect network externalities in the two-sided market. When the extent of indirect network externalities is sufficiently strong, increased network benefits can improve social welfare. By contrast, if indirect network externalities are weak, then the socially conscious platform might be detrimental to society.
Evolution of thyroid cancer biomarkers: from laboratory test to patients’ clinical management
Authors: Garo Maria Luisa , Campennì Alfredo , Petranovic-Ovcaricek Petra , D’Aurizio Federica , Giovanella Luca
Published: November 2022

Over the past three decades, laboratory medicine has significantly evolved thanks to technological advances made possible by new materials and evidence. Clinicians’ ongoing requests for powerful, rapid, and minimally invasive tests has led manufacturers to develop rapid, accurate, and sensitive tests that can increase diagnostic accuracy and improve follow-up, bringing laboratory medicine ever closer to personalized medicine. The aim of this study was to critically review the main problems of the current Tg and CT biomarkers for the diagnosis/monitoring of DTC and MTC, respectively, and to identify the advantages and challenges of using the new laboratory biomarkers in the clinical management of patients with differentiated and medullary thyroid cancer. Insufficient harmonization of Tg and CT assays and lack of interchangeability of laboratory results and cutoff values pose challenges for comparability and standardization of procedures and methods. New diagnostic and monitoring approaches such as PCT or the Tg doubling time have proven to be effective. Close collaboration between clinicians and laboratory specialists remains essential to translate the advantages and limitations of current assays into appropriate clinical interpretation criteria. Over the years, the journal Clinical Chemistry and Laboratory Medicine (CCLM) has taken many steps to develop advanced research and technology in the diagnosis and monitoring of tumor cancer and to help clinicians translate it into clinical practice.
Finite Element Approximations for PDEs with Irregular Dirichlet Boundary Data on Boundary Concentrated Meshes
Authors: Pfefferer Johannes , Winkler Max
Published: November 2022

This paper is concerned with finite element error estimates for second order elliptic PDEs with inhomogeneous Dirichlet boundary data in convex polygonal domains.
The Dirichlet boundary data are assumed to be irregular such that the solution of the PDE does not belong to

H
2

⁢

(
Ω
)

{H^{2}(\Omega)}

but only to

H
r

⁢

(
Ω
)

{H^{r}(\Omega)}

for some

r
∈

(
1
,
2
)

{r\in(1,2)}

. As a consequence, a discretization of the PDE with linear finite elements exhibits a reduced convergence rate in

L
2

⁢

(
Ω
)

{L^{2}(\Omega)}

and

H
1

⁢

(
Ω
)

{H^{1}(\Omega)}

. In order to restore the best possible convergence rate we propose and analyze in detail the usage of boundary concentrated meshes. These meshes are gradually refined towards the whole boundary. The corresponding grading parameter does not only depend on the regularity of the Dirichlet boundary data and their discrete implementation but also on the norm, which is used to measure the error. In numerical experiments we confirm our theoretical results.
Effect of pipe rotation on heat transfer to laminar non-Newtonian nanofluid flowing through a pipe: a CFD analysis
Authors: Meesala Sai Kiran , Govinda Rao Budda , Yellapragada Datta Bharadwaz
Published: November 2022

The present numerical study is aimed at investigating the effect of rotation on heat transfer to non-Newtonian nanofluid flowing through a pipe. Non-Newtonian fluid flow under laminar condition with heat transfer finds the applications in various industries like food processing, pharmaceutical and polymer etc. Various proportions (1–3%) of copper nanoparticles are mixed with water to study the heat transfer rates non-Newtonian nanofluid flowing through the rotating pipe. Effect of rotation rate on heat transfer rates are also studied. In this study for 1% nanofluid at a constant rotation rate of 0.8, the Nusselt number is increased by 119.45%. The highest thermal performance factor (TPF) is 1.74, observed at N = 0.8, Pe = 5000, and for 1% volume concentration of non-Newtonian nanofluid.
Isomorphisms of Orlicz spaces
Authors: Tabatabaie Seyyed Mohammad , Latifpour Mahdi
Published: November 2022

In this paper, we provide some isomorphism preserving conditions for (weighted) Orlicz spaces, and as a main result, it is proved that if there exist a bicontinuous linear operator

T
:

L

w
1

Φ

⁢

(

G
1

)

→

L

w
2

Φ

⁢

(

G
2

)

{T\colon L^{\Phi}_{w_{1}}(G_{1})\rightarrow L^{\Phi}_{w_{2}}(G_{2})}

and a mapping

a
↦

(

ξ
⁢

(
a
)

,

h
⁢

(
a
)

)

{a\mapsto(\xi(a),h(a))}

from

G
1

{G_{1}}

to

ℂ
×

G
2

{\mathbb{C}\times G_{2}}

with

T
⁢

λ
a

=

ξ
⁢

(
a
)

⁢

λ

h
⁢

(
a
)

⁢
T

{T\lambda_{a}=\xi(a)\lambda_{h(a)}T}

for all

a
∈

G
1

{a\in G_{1}}

, then

G
1

{G_{1}}

and

G
2

{G_{2}}

are isomorphic, where Φ is a

Δ
2

{\Delta_{2}}

-regular Young function,

G
1

{G_{1}}

and

G
2

{G_{2}}

are locally compact groups and

w
1

{w_{1}}

and

w
2

{w_{2}}

are weight functions. Also, for a class of Young functions Φ, we show that if

C
⁢

V
Φ

⁢

(

G
1

)

{CV_{\Phi}(G_{1})}

and

CV
Φ

⁢

(

G
2

)

{\mathrm{CV}_{\Phi}(G_{2})}

are isometrically isomorphic, then

G
1

{G_{1}}

and

G
2

{G_{2}}

are isomorphic,

CV
Φ

⁢

(

G
i

)

{\mathrm{CV}_{\Phi}(G_{i})}

is the space of all convolution operators on the Orlicz space

L
Φ

⁢

(

G
i

)

{L^{\Phi}(G_{i})}

for

i
=

1
,
2

{i=1,2}

.
Spectrality of homogeneous Moran measures on ℝ
n
Authors: Fu Yan-Song , Tang Min-Wei
Published: November 2022

A Borel probability measure on

ℝ
n

{\mathbb{R}^{n}}

is called a spectral measure if the Hilbert space

L
2

⁢

(
μ
)

{L^{2}(\mu)}

has an orthonormal basis consisting of exponentials. In the present paper we show that, under a mild condition, compatible pairs and lacunary sequences generate homogeneous Moran spectral measures μ on

ℝ
n

{\mathbb{R}^{n}}

. As a consequence we show that compatible pairs are necessary and sufficient conditions for certain planar homogeneous Moran measures to become spectral ones.
How vector space models disambiguate adjectives: A perilous but valid enterprise
Authors: Montes Mariana , Geeraerts Dirk
Published: November 2022

The present study is part of a larger research project developing computational tools for large-scale corpus-based semantic analyses. One such tool represents semantic structure with vector space models (VSMs). The paper shows that this tool and the models built require a deeper understanding, especially with a view to how its results relate to cognitive theories of meaning. Although token-based VSMs are increasingly used in corpus-based cognitive semantics, we believe it is insufficiently appreciated how alternative parameter settings deal with a range of semantic issues, such as granularity of meaning, prototypicality of the domain of application and interaction with syntactic patterns. For the purpose of this paper, we will focus on only one of those issues, viz. the prototypicality of the domain of application, presenting the results of three of our case studies on the Dutch adjectives heilzaam, hoekig, hachelijk and geldig. The models presented are built from a 520MW corpus of contemporary Dutch and Flemish newspapers and by varying parameters such as window size, part-of-speech and frequency thresholds in the selection of features. The resulting VSMs are evaluated through visual analytics: although multidimensional, they can be reduced to 2D and represented in scatterplots where more similar tokens appear closer to each other. The color-coding with manual sense tags employed here makes it possible to compare the groupings provided by human annotators with those of the computational models in a way consistent with the cognitive approach to meaning and categorization.
Lexical Integrity: A mere construct or more a construction?
Authors: Cappelle Bert
Published: November 2022

This paper reviews the so-called Lexical Integrity Principle, resting on the assumption that morphology and syntax are distinct components of grammar. In the forty-odd years since its original formulation, this principle has repeatedly come under fire. Phrasal compounds ([[Lexical Integrity]NP
Principle]N being an example!) are often adduced as counterevidence, but I here argue that phrases generally don’t appear inside compounds and that the principle therefore cannot be so easily discarded. The claim that parts of words cannot be syntactically manipulated has remained relatively unchallenged, which is another reason to uphold some aspects of Lexical Integrity. The separability of particle verbs, though, presents a well-known potential problem. I address recent voices that particle verbs, despite neuroscientific evidence of their lexical status, are not words, maintaining they can be items with word status, given for example their occurrence in the [V the Ntaboo-word
out of NP] construction. A constructionist approach to alternation phenomena offers a solution to the separability issue, which consists in having schematic particle verb constructions whose grammatical status (and not just word order) is underspecified. As words, particle verbs stay together; as phrases, their parts can separate. To salvage the Lexical (or, better, Morphological) Integrity of words, this paper proposes a principle –a construction of sorts – that is a generalization emerging from how we use words.
Cognitive Linguistics meets Interactional Linguistics: Language development in the arena of language use
Authors: Behrens Heike , Pfänder Stefan
Published: November 2022

We take as our point of departure the usage-based assumption that grammar emerges from language use and briefly review the claims regarding the storage of linguistic experiences and the gradual nature of generalization. We argue that in addition to studying the long-term effects of distributional evidence in the input, the usage-based paradigm should take up related research in pragmatics and cognitive linguistics with a focus on the “online” properties of the situation. By putting interaction center-stage, we can study the development of children’s emerging conversational skills, but also draw on the full richness of the situation, which provides further cues to language learning.
Constructionist approaches to creativity
Authors: Hoffmann Thomas
Published: November 2022

Humans are an incredibly creative species – our minds have evolved to a degree that has enabled us to think original thoughts and come up with novel solutions to a great number of problems. One domain of human cognition that has recently received considerable attention is linguistic creativity. The present contribution will take a closer look at how Construction Grammar can account for various types of verbal creativity. In addition to this, it will also explore the implications of creative utterances for Construction Grammar as a mental theory of language.
Some identities on degenerate hyperharmonic numbers
Authors: Kim Taekyun , Kim Dae San
Published: November 2022

The aim of this paper is to investigate some properties, recurrence relations and identities involving degenerate hyperharmonic numbers, hyperharmonic numbers and degenerate harmonic numbers. In particular, we derive an explicit expression of the degenerate hyperharmonic numbers in terms of the degenerate harmonic numbers. This is a degenerate version of the corresponding identity representing the hyperharmonic numbers in terms of harmonic numbers due to Conway and Guy.
Resting heart rate variability as a diagnostic marker of cardiovascular dysautonomia in postural tachycardia syndrome
Authors: Inbaraj Ganagarajan , Udupa Kaviraja , Vasuki Prathyusha P. , Nalini Atchayaram , Sathyaprabha Talakad N.
Published: November 2022

Objectives

Postural orthostatic tachycardia syndrome (POTS) is a disorder of the autonomic nervous system characterised by orthostatic intolerance and orthostatic tachycardia without hypotension. Heart rate variability (HRV) is the most reliable and objective tool for assessing autonomic dysfunction severity. In the present study, we aimed to investigate HRV changes in resting supine position, predicting severity and cardiovascular risk in patients with POTS.

Methods

We compared 100 POTS patients with 160 healthy controls matched for age and gender in a case-control design. Along with clinical characterization, heart rate variability was evaluated using ambulatory 5 min ECG in lead II and expressed in frequency and time-domain measures.

Results

The resting heart rate of patients with POTS was significantly higher than that of healthy controls. In HRV measures, root mean square successive difference of RR intervals (RMSSD), total and high frequency (HF) powers were statistically lower with an increased low frequency (LF) to high-frequency ratio in patients with POTS compared to healthy controls. Further, stepwise logistic regression analysis showed increased basal HR and LF/HF as significant predictors of POTS and its severity.

Conclusions

This is the first study on a large cohort of patients with POTS from India wherein HRV was assessed. The study showed reduced parasympathetic activity and increased sympathetic activity in patients with POTS compared to healthy controls. These findings of increased resting heart rate and LF/HF were found to be potential predictors of POTS and future cardiovascular risks, which need to be replicated in a larger and more homogenized cohort.
The Long and Winding Road to Local Fiscal Equity in the United States: A Fifty-Year Retrospective
Authors: Martinez-Vazquez Jorge , Timofeev Andrey
Published: November 2022

Unlike many other countries, the United States does not have a comprehensive federal transfer scheme for explicit fiscal equalization but rather employs an array of categorical and block grants, some of which are formula-based while others are project-driven. However, the allocation of many of these grants has equalization effects resulting in the narrowing of fiscal disparities among jurisdictions. Few studies have attempted to quantify the extent of equalization achieved with federal and state grants in a manner that would allow comparisons across states and over time. In this study, we set out to measure the extent of equalization across local governments in the United States that is implicit in the federal grants system and more explicit in the grants implemented by the individual states. Rather than focusing on specific types of local services, we look at the evolution of per capita resources available to all types of local governments combined.
The Manchester Voices Accent Van: taking sociolinguistic data collection on the road
Authors: Drummond Rob , Dann Holly , Tasker Sarah , Ryan Sadie Durkacz
Published: November 2022

This article details the methodology behind the Manchester Voices Accent Van, and the accompanying online Virtual Van. In 2021, the project travelled around Greater Manchester in a van converted into a mobile recording booth, asking people to climb aboard and take part in an unsupervised interview about language and identity in the region. Participants could also take part from their own home through a bespoke website, called the Virtual Van, which asked the same interview questions as the physical Van and recorded speakers through their computer/phone microphone. With a view to informing others who might want to use similar methods in the future, we present a detailed description of the methodology here, as well as an overview and sample of the data collected. We conclude with a reflection on the elements of the data collection that went well, and a discussion of improvements and considerations for future research using this methodology.
Site-specific genome editing in treatment of inherited diseases: possibility, progress, and perspectives
Authors: Huang Chao , Li Qing , Li Jinsong
Published: November 2022

Advancements in genome editing enable permanent changes of DNA sequences in a site-specific manner, providing promising approaches for treating human genetic disorders caused by gene mutations. Recently, genome editing has been applied and achieved significant progress in treating inherited genetic disorders that remain incurable by conventional therapy. Here, we present a review of various programmable genome editing systems with their principles, advantages, and limitations. We introduce their recent applications for treating inherited diseases in the clinic, including sickle cell disease (SCD), β-thalassemia, Leber congenital amaurosis (LCA), heterozygous familial hypercholesterolemia (HeFH), etc. We also discuss the paradigm of ex vivo and in vivo editing and highlight the promise of somatic editing and the challenge of germline editing. Finally, we propose future directions in delivery, cutting, and repairing to improve the scope of clinical applications.
Flexible graphene oxide/polyacrylonitrile composite films with efficient ultraviolet shielding and high transparency for the protection of paper-based artifacts
Authors: Teng Cheng , Liu Ximei , Lin Mingjun , Li Jianlin
Published: November 2022

Paper-based artifacts, such as ink and wash paintings, paper cuts, etc., when exposed in environment for a long time, are prone to embrittling, yellowing and ageing because of ultraviolet light and weather elements. In a museum, special measurements are adopted to avoid these damages, but for common households, a functional coating is a good solution. However, this is not an easy task as the coating must be removable and cannot damage the articles. Graphene oxide (GO) has the potential as ultraviolet shielding material for the protection of paper-based artifacts, but the application of monolithic GO coatings on paper-based artifacts is difficult. In this work, feasible GO/polyacrylonitrile composite films were prepared and their protection properties for rice paper were explored experimentally. When GO loading reached 2 %, the UV-A and UV-B blocking percentages of the film were 57.47 % and 70.86 %, respectively, with a visible light transmittance of 77.09 %. These films also performed good moisture resistance. With a good flexibility, they could be easily transferred onto and peeled off the rice paper surface without damaging the paper texture and patterns on it. These films basically meet the demand of paper-based artifacts protection.