bluuebunny/crossref_metadata_2025 huggingface dataset:
Iris Murdoch e Clarice Lispector: A tradução do romance a cabeça decepada
Authors: Stefani Mônica , Pereira Tiago Ferreira
Published: October 2021

As traduções fomentam um diálogo importante e necessário entre leitores de diferentes grupos linguísticos e culturais e cabe ao pesquisador refletir sobre o fazer tradutório de modo a elucidar seus mecanismos e efeitos. Assim, este artigo apresenta uma análise contrastiva de trechos selecionados do romance A Severed Head (1961), da autora anglo-irlandesa Iris Murdoch, e de A Cabeça Decepada, tradução atribuída a Clarice Lispector (conforme nome na capa), publicada pela editora Artenova em 1973. Murdoch e Lispector celebraram seus centenários de nascimento em 2019 e 2020, respectivamente. Nesta pesquisa, para avaliar como o texto de Murdoch chegou ao público leitor brasileiro, justapomos os excertos e observamos aspectos linguísticos, culturais e intertextuais, tendo Berman (1998), Coracini (2017) e Genette (2009; 2010) como referencial teórico. Este exercício é duplamente esclarecedor: se junta aos demais estudos que abordam Clarice Lispector (como tradutora ou não), e introduz Iris Murdoch no campo dos Estudos Literários (e também de tradução) no Brasil.
A 15-year Study of the Spatial Distribution of Rutilus rutilus and Perca fluviatilis in Late Summer in Two Shallow Lakes With Contrasting Trophic State
Authors: PEKCAN HEKIM Zeynep , LAURİDSEN Torben , SØNDERGAARD Martin , JOHANSSON Liselotte , SHURKHUU Tserenpil , JEPPESEN Erik
Published: October 2021

Roach (Rutilus rutilus) and perch (Perca fluviatilis) are dominant species in northern-temperate lakes of Europe, their relative importance depending on trophic state and habitat complexity. We studied the habitat distribution of roach and perch over a 15-year period in two Danish lakes, Lake Væng, undergoing major changes in water clarity and macrophyte coverage, and the permanent turbid Lake Søbygård. We used multi-mesh sized gill nets in 5-6 different sections of the lakes following the same program in all years. Both species were evenly distributed in the sections and among habitats, in Lake Væng during the turbid period and in Lake Søbygård during the whole study period. During the clear-water period in Lake Væng, however, the distribution of roach and perch was uneven and the density negatively correlated with macrophyte coverage and density, but the strength of the relationship differed between the two species and between small (≤ 8 cm for roach and <10 cm for perch) and larger fish. Our results suggest that water clarity and macrophyte density were of key importance in determining roach and perch distribution in these two shallow lakes.
Limitation of the Right to Acquire and Possess Civilian Weapons for Medical Reasons: An Invitation to Discussion
Authors: Schmidt A. A.
Published: October 2021

The paper analyzes the legal mechanism for issuing permits for the acquisition and possession of civilian weapons, defines the role of legal restrictions, including medical contraindications, in the state licensing and permitting policy. Based on the analysis of the reasons and conditions for deviant behavior with weapons, motives of crimes with the use of civilian weapons, it is concluded that the methods used to identify medical contraindications to the acquisition and possession of weapons are ineffective, and the list of contraindications is inadequate. The author provides a criminal law concept for assessing the impact of mental disorder on the assessment of behavioral risks. The author puts forward hypotheses about the need to take into account the propensity to violence, aggression, depression, suicidal manifestations, as well as the lack of formation of the regulatory mechanisms of the psyche when making a conclusion about the absence of medical contraindications to the possession of civilian weapons. The proposed amendments to the legislation on weapons will make it possible to identify and promptly prevent deviant, including suicidal, behavior of the owners of civilian weapons. The paper analyzes the existing methods and the choice of formalized psychodiagnostic techniques. It is proposed to use psychophysiological examinations to make informed conclusions about the absence of medical contraindications for using a weapon.
A Call to the Profession: Cross-Cultural Competence and Learning from a Sister Profession
Authors: Dieser Rodney
Published: October 2021

Cross-cultural competence has increased in applied professions, including occupational therapy, physical therapy, psychiatry, mental health counseling, and social work. Despite three decades of research and scholarship advocating the need for cross-cultural competence in TR/RT, it remains lacking. This paper is a call for the profession to do better. Based on (1) learning how American Counseling Association and the National Board of Certified Counselors have positioned cross-cultural awareness, knowledge, and skills as core competence in national and international practice, (2) examining cross-cultural research and scholarship in TR/RT, and (3) drawing from ATRA’s Higher Education Committee Task Force, this paper suggests specific recommendations to develop cross-cultural competence in TR/RT.
advogados em cor e gênero
Authors: Dos Santos Eneida Maria , De Lacerda Carelli Rodrigo
Published: October 2021

A pandemia da COVID-19 trouxe importantes consequências para a forma de exercer a advocacia, mas também representou graves impactos econômicos para a categoria. O estudo, baseado em pesquisa empírica realizada junto à advocacia no Estado do Rio de Janeiro, demonstra que os impactos no trabalho e na condição econômica derivados da pandemia foram maiores em relação aos negros e às mulheres, e, em análise interseccional, nas mulheres negras. A conclusão é que há uma distribuição desigual dos efeitos da pandemia em relação a estes grupos, que se demonstram vulneráveis social e economicamente. Com o intuito de se interpretar os dados encontrados, realizou-se uma revisão bibliográfica sobre os estudos raciais, feministas e do feminismo negro, que esclarecem o histórico de opressão e narrativas construídas socialmente que fazem com que ainda negros, mulheres e mulheres negras sejam discriminados no mercado do trabalho, no século XXI, em especial a mulher negra que se encontra em situação mais precarizada, por experimentar os abusos das categorias racial e de gênero conjuntamente, o que é elucidado sob a perspectiva interseccional.
16. ASIR DİVAN ŞAİRLERİNDEN SİRÂCÎ’NİN MANZUM HADİS TERCÜMELERİ
Authors: CEYHAN Adem
Published: October 2021

Türk edebiyatı tarihinde 14. asırdan çağımıza kadar pek çok kırk hadis derleme, tercüme ve şerhinin meydana getirildiği ilgililerce bilinen bir gerçektir. 16. yüzyılda kırk hadis toplama, çeviri ve açıklama çalışmaları, önceki asırlara nazaran kat kat artmış; bu türde –şimdiki tesbitlerimize göre- otuz dolayında eser ortaya konmuştur. Anılan çağda Usûlî, Fuzûlî, Fevrî, Âşık Çelebi gibi kırk veya bu sayıdan bir miktar daha fazla hadis tercüme eden şairlerin bir kısmı divan sahibidir. Divanındaki çeşitli şiirlerden anlaşıldığına göre Sirâcî de 16. asır Osmanlı şairlerinden olup Hz. Peygamber’e, onun Ehl-i Beyt’i, dört dostu, torunları Hz. Hasan, Hüseyin ve on iki imama sevgiyle bağlı bir edebî şahsiyettir. Mütercim, divanının başında yer alması ve okuyanların dua etmesi isteğiyle kırkaltı hadisi ikişer beyitli nazm ve kıtalar şeklinde Türkçeye çevirmiştir. Bu çalışmada Sirâcî’nin hadis tercümeleri ele alınıp şekil ve öz yönünden incelenmiş; anılan kitapçıkta Yenice Vardarlı Usûlî’nin (ö. 945/ 1538) aynı türden eserinin, nazım biçimi, Hz. Peygamber’e ait sözlerin seçilmesi ve çevrilmesi yönlerinden tesirli olduğu, bazı ipuçlarından hareketle ileri sürülmüştür. Şairin yaşadığı çağ ve kişiliği hakkında, divanındaki şiirlere dayanılarak bilgi verilmiş; o asırda bu mahlası kullanan edebî şahsiyetin kimliği, tarihî biyografik kaynaklardan faydalanılarak tesbit edilmeye çalışılmıştır. Nihayet Sirâcî’nin hadis tercümeleri, Latin harflerine ve günümüz Türkçesine çevrilerek okuyucuların incelemesine arz edilmiştir.
MÜSTAKÎMZÂDE SEYYİD SÜLEYMÂN SA’DEDDİN EFENDİ’NİN HULÂSATÜ’L-HEDİYYE’Sİ
Authors: BEKLEN Sadık
Published: October 2021

Bu çalışmada Müstakîmzâde Seyyid Süleyman Sa’deddin Efendi’nin Hulâsatü’l-Hediyye adlı eserinin tanıtımı yapılacaktır. Kendi döneminin önemli şahsiyetlerinden biri olan Müstakîmzâde pek çok alanda eser kaleme almış üretken bir yazardır. Müstakîmzâde’nin Hulâsatü’l-Hediyye adlı eseri, Mustafa Nazmi Efendi adında bir yazarın kaleme almış olduğu Hediyetü’l-İhvân adlı eserin muhtasârıdır. Ancak Müsatkîmzâde, Nazmi’nin dil ve üslup açısından çok ağır bulduğu eserini klasik özet tekniğinin dışında bir yol izleyerek adeta kendi yetkin üslubu ile yeniden kaleme almıştır. Çalışmada bu eser şekil ve içerik özellikleri bakımından tanıtılacaktır.
BİR MEYVEDEN DAHA FAZLASI: LİMON/KLASİK TÜRK EDEBİYATI METİNLERİNDE TESPİTİ VE ANLAM ÇERÇEVESİ
Authors: GÖRE Zehra
Published: October 2021

Tadı bu kadar ekşi olmasına ve üstelik tek başına da yenilmemesine rağmen limon, başka hiçbir meyve ile kıyaslanamayacak ölçüde insan hayatında önemlidir. Limonu bu şekilde kıymetli kılan onun bir mutfak unsuru olması değildir. Dikkatle düşünüldüğünde her zaman evlerde bulundurulmasına özen gösterilen bu meyvenin içinin, dışının hatta kokusunun temizlikten kozmetiğe hayatın her alanına faydalar sunduğu anlaşılır. Hasta olunca şifa bulmak üzere ilk akla gelendir. Rengi sarının en güzel, en tatlı tonudur. Şekli, yuvarlaklığıyla farklı hayaller kurmaya fırsat verir. Dört mevsim yapraklarını dökmediği için her dem bulunduğu bahçede görsel bir şölen yarattığı gibi etrafa yaydığı kokusuyla dimağı şenlendirir. Suyundan elde edilen limonata, yapılması en zahmetsiz ama en ferahlatıcı içecektir. Geçmişten günümüze sanatın her alanında ilgi çekici bulunmuş bir metafordur. Kısacası olmazsa olmaz denilecek türden tabiatın insanlığa armağan ettiği mucizevi bir meyvedir.
Bu makalede önce limonun tarihçesi araştırılmış, adlandırılması ile ilgili kuramsal bir derleme oluşturulmuştur. Klasik Türk edebiyatında insana dair her unsurun bir şekilde yerini bulduğu gerçeğinden hareketle de metinler aracılığıyla bir meyve olarak limonun izi sürülmüştür. Başta divanlar olmak üzere manzum ve mensur eserler taranmış limonun klasik Türk edebiyatı metinlerinde kullanılış biçimleri tespit edilmiştir. Müelliflerin hangi duygu ya da durumu ifade etmek üzere limonu hatırladıkları, hangi çağrışımlarını kullandıkları değerlendirilerek limon etrafında oluşan anlam çerçevesi ele alınmıştır. Tespitlerde limon ve onunla alakalı unsurların edebiyatın mecazlar aynasına yansıyan görüntüleri ortaya konulmuştur.
Fluxo de operações do crime organizado: questões conceituais e metodológicas | Flow of Organized Crime Operations: Conceptual and Methodological Issues
Authors: Adorno Sérgio
Published: October 2021

O artigo trata de questões conceituais e metodológicas relacionadas à abordagem sociológica do crime organizado. Seus principais argumentos baseiam-se em pesquisa cujo objeto trata de reconstruir o fluxo de operações que mobiliza o tráfico internacional de drogas ilícitas na América Latina, desde o início da cadeia produtiva nos países andinos até o mercado consumidor brasileiro e internacional. Suas fontes de informação compreendem fundamentalmente documentos e relatórios de organizações governamentais e não-governamentais, além de dados sobre apreensões de drogas. O artigo pretende chamar a atenção para problemas relacionados à aplicação de conceitos e ao emprego de fontes documentais que podem restringir o alcance de resultados.
Teatro horizontal
Authors: Jacopini Juliano Ricci
Published: October 2021

Tratarei da perspectiva teatro horizontal refletida, defendida e experienciada pela Cia. Labirinto de Teatro, elaborada através de uma década junto ao Festival Internacional de Arte-Educação Fronteiras Brasil, estabelecendo um diálogo entre arte e comunidade a partir de um trabalho via partilha de experiências, que apanha os princípios da autoficção como ato criativo poético e político.
Educador social eu sou: quem eu era e no que me tornei, como e com quem...
Authors: Vieira Ana Maria , Vieira Ricardo , Marques José Carlos
Published: October 2021

Este texto resulta da análise dos primeiros dados recolhidos no âmbito de um projeto maior que dá pelo nome de “Educadores sociais em Portugal: quem são, onde estão e o que fazem? Identidades e transformações”. Os seus autores estão ligados ao desenvolvimento da educação/pedagogia social em Portugal e dos seus profissionais, os educadores sociais, que têm acompanhado em formações de licenciatura, mestrado e doutorado, em estágios em diversas instituições socioeducativas, de reinserção social, de acolhimento familiar, e em escolas, que assumem que a educação começa fora da escola, passa por ela e estende-se para além dela. O educador social é, assim, um mediador intercultural, um mediador socioeducativo, um construtor de pontes entre culturas, pessoas, grupos e comunidades, que tem formação académica para o efeito, mas que, como aqui pretendemos apontar, nas palavras dos sujeitos escutados, tem momentos marcantes que só ele pode assinalar, momentos formativos que considera significativos na sua história de vida para chegar a ser o profissional que é.
Monograf Aplikasi Biofertilizer Pada Kedele Tahan Naungan
Authors: Sutarman Sutarman
Published: October 2021

Puji syukur kehadirat Allah SWT atas tersusunnya monograf dengan judul: “Aplikasi Biofertilizer pada Kedele Tahan Naungan” yang merupakan salah satu luaran penelitian sesuai kompetensi penyusun di bidang kesehatan dan penyakit tanaman serta mikrobiologi tanah pertanian. Buku ini disusun berdasarkan hasil penelitian dan kajian literatur yang bersumber pada berbagai artikel jurnal Internasional relevan terkait. Nilai kebaruan penelitian ini adalah pemanfaatan isolat nodul akar tumbuhan liar putri malu (Mimosa pudica) yang diintegrasikan dengan biofertilizer endomikoriza dan Trichoderma dari lantai hutan pada tanaman kedele tahan naungan. Hasil penelitian ini diharapkan dapat menjawab tantangan pewujudan swasembada kedele dengan mengoptimalkan lahan hutan tanaman, perkebunan, dan sistem tumpangsari lahan kering lainnya yang belum pernah ditanami kedele sebelumnya dengan kondisi intensitas sinar matahari yang relatif sedang hingga rendah. Pada kesempatan ini penulis menyampaikan terima kasih kepada: Rektor Universitas Muhammadiyah Sidoarjo (UMSIDA), Dekan, Ketua Program Studi Agroteknologi serta Kepala Laboratorium Agrokompleks Fakultas Pertanian UMSIDA atas dukungan moril dan fasilitas yang disediakan bagi kelancaran penelitian dan penyusunan buku ini. Semoga karya ilmiah ini bermanfaat.
Ketahanan Pangan Rumah Tangga Penerima Bantuan Program Desa Mandiri Pangan di Kabupaten Sumba Tengah
Authors: Sabaora Yosua Umbu Osa , Priyanto Sony Heru , Prihtanti Tinjung Mary Mary
Published: October 2021

English
The Food Resilient Village is a major program of the Ministry of Agriculture to ensure food security of rural households which effectiveness should be evaluated. This study aims to determine status, determinants, and food coping strategies of the household participants of the Food Resilient Village Program in Sumba Tengah Regency. The data was collected through a survey with 85 randomly selected household samples in 2019. The food security status was determined through a cross tabulation of food expenditure share and the level of energy consumption. The determinants of food security were identified using the logistic regression analysis. Food fulfillment strategy was evaluated with a food coping index. Results show that 25.58% sample households were food insecure, 40.00% were vulnerable food insecure, 14.12% were food insufficient, and 20.00% were food insecure. The food security was positively affected by the age of the family head, house hold income, rice prices, dummy balanced areas of paddy fields and dry land. The negative determinants were the number of household members, land size controlled and meat prices chicken. In general the coping strategy was at moderate level with a categorial composition of low 14.12%, medium 51.76%, and high 34.12%.

Indonesian
Program Desa Mandiri Pangan adalah salah satu program utama Kementerian Pertanian untuk mewujudkan ketahanan pangan rumah tangga perdesaan yang perlu diteliti efektivitasnya. Penelitian ini bertujuan untuk menentukan status, mengindentifikasi determinan, dan mengevaluasi strategi penyesuaian pangan rumah tangga penerima program Desa Mandiri Pangan di Kabupaten Sumba Tengah. Data dikumpulkan melalui survei dengan responden sebanyak 85 rumah tangga contoh yang dipilih secara acak sederhana pada tahun 2019. Status ketahanan pangan ditetapkan berdasarkan kombinasi silang antara pangsa pengeluaran pangan dan kecukupan konsumsi energi rumah tangga. Determinan ketahanan pangan dianalisis dengan regresi logit. Strategi penyesuaian pangan diukur dengan food coping index. Hasil penelitian menunjukkan bahwa ketahanan pangan rumah tangga yang dalam kategori tahan pangan sebesar 25,88%, rentan pangan 40,00%, kurang pangan 14,12%, dan rawan pangan 20,00%. Faktor-faktor yang berpengaruh positif terhadap ketahanan pangan adalah umur kepala keluarga, pendapatan rumah tangga, harga beras, dan agroekosistem berimbang lahan sawah dan lahan kering, sedangkan yang berpengaruh negatif adalah jumlah anggota rumah tangga, luas penguasaan lahan, dan harga daging ayam. Secara umum, strategi penyesuaian pangan yang dilakukan responden berada pada tingkatan sedang dengan komposisi kategori rendah sebanyak 14,12%, sedang 51,76%, dan tinggi 34,12% dari total rumah tangga contoh.
The System of Self-Consistent QSPR-Models for Refractive Index of Polymers
Authors: Toropov Andrey A. , Toropova Alla P. , Kudyshkin Valentin O.
Published: October 2021

Quantitative structure-property/activity relationships (QSPRs/QSARs) are a component of modern natural science. The system of self-consistent models is a specific approach to build up QSPR/QSAR. A group of models of refractive index for different distributions in training and test sets compared. This comparison is a basis to formulate the system of self-consistent models. The so-called index of ideality of correlation (IIC) has been used to improve the predictive potential of models of the refractive index of different polymers (n=255). The predictive potential of the suggested models is high since the average value of the determination coefficient for the validation set is 0.885. In addition, the system of self-consistent models may be applied as a tool to assess the predictive potential of an arbitrary QSPR-approach.
Deciphering the Mechanisms of Pre-Attachment Striga Resistance in Sorghum Using Genome-Wide Association Studies
Authors: Mallu Tesfamichael S , Irafasha Gilles , Mutinda Sylvia Mbula , Owuor Erick , Githiri Stephen Mwangi , Odeny Damaris Achieng , Runo Steven
Published: October 2021

Witchweeds (Striga spp.) greatly limit production of Africa’s most staple crops. These parasitic plants use strigolactones (SLs) – chemical germination stimulants, emitted from host’s roots to germinate, and locate their hosts for invasion. This information exchange provides opportunities for controlling the parasite by either stimulating parasite seed germination without a host (suicidal germination) or by inhibiting parasite seed germination (pre-attachment resistance). We sought to determine genetic factors that underpin Striga pre-attachment resistance in sorghum using the genome wide association study (GWAS) approach. Results revealed that Striga germination was associated with genes encoding hormone signaling functions e.g., the Novel interactor of jaz (NINJA) and, Abscisic acid-insensitive 5 (ABI5). This pointed toward abscisic acid (ABA) and gibberellic acid (GA) as probable determinants of Striga germination. To test this hypothesis, we conditioned Striga using: ABA, ABA + its inhibitor fluridone (FLU), GA or water. Unexpectedly, Striga conditioned with FLU germinated after 4 days without SL. Upon germination stimulation using sorghum root exudate or the synthetic SL GR24, we found that ABA conditioned seeds had above 20-fold reduction in germination. Conversely, FLU conditioned seeds recorded above 20-fold increase in germination and conditioning with GA caused at least 1.5-fold reduction in Striga seed germination. Germination assays using seeds of a related parasitic plant (Alectra vogelii) showed similar degrees of stimulation and reduction of germination by the hormones further affirming the hormonal crosstalk. Our findings have far-reaching implications in the control of some of the most noxious pathogens of crops in Africa.
Development of an Optimization Pipeline of Asymmetric PCR Towards the Generation of DNA Aptamer- A Guide for Beginners
Authors: Yeoh Tzi Shien , Anna Andrew , Hock Tang Thean , Citartan Marimuthu
Published: October 2021

Asymmetric PCR is one of the most utilized strategies in ssDNA generation towards DNA aptamer generation due to its low cost, robustness and the low amount of starting template. Despite its advantages, careful optimization of the asymmetric PCR is still warranted to optimize the yield of ssDNA. In this present study, we have developed an extensive optimization pipeline that involves the optimization of symmetric PCR, optimization of primer amounts/ratios, PCR cycles, annealing temperatures, template concentrations, Mg 2+ /dNTP concentrations and the amounts of Taq Polymerase. To further boost the generation of ssDNA, we have also integrated an additional single-stranded DNA generation method via lambda exonuclease and biotin-streptavidin-based separation into the optimization pipeline to further improve the yield of ssDNA generation. We have acquired 700 ± 11.3 and 820 ± 19.2 nM for A-PCR-lambda exonuclease and A-PCR-biotin-streptavidin-based separation, respectively. We urge to develop a separate optimization pipeline of asymmetric PCR for each different randomized ssDNA library before embarking on any SELEX studies.
Collocation Method for Fuzzy Volterra Integral Equation of the Second Kind with Weakly Singular Kernels
Authors: Alijani Zahra , Kangro Urve
Published: October 2021

In this paper we consider fuzzy Volterra integral equation of the second kind with weakly singular kernel. We propose piecewise spline collocation methods with a graded mesh. By increasing the number of collocation points we show that the numerical solution exists and converges to the exact solution. We obtain exact convergence vlues depending on smoothness of the solution and on the grading parameter of the mesh.We give sufficient conditions for the fuzziness of the approximate solution. The proposed method is illustrated by numerical examples which confirm the theoretical convergence estimates.
An Inference of The Wading Depths of The Cranes in Wintering Wetlands Through Photographic Sampling: a Case Study of Black-Necked Cranes (Grus Nigricollis) in Caohai Wetland, China
Authors: Gou Xue , Sun Xijiao , Khattak Romaan Hayat , Zhao Ruisha , Hu Yao , Hu Canshi , Zhang Mingming , Su Haijun
Published: October 2021

Several overwintering crane species like Black-necked cranes (Grus nigricollis) mainly depends on wetlands for foraging or roosting, preferring stable water depths. Understating the wading depths of cranes is a pressing concern for the better management of wetlands and robust conservation of the overwintering cranes populations. Yet, practically it is very difficult to precisely measure the wading depths due to several limitations like, inaccessibility and sampling difficulties. In the current study a sample of 1288 wading photographs of cranes, based on the constancy of proportion of tibiotarsus to tarsometatarsus were taken in Caohai wetland situated in the Northwest Guizhou Province of south west China. Caohai Wetland is the biggest overwintering wetland around the world, and a very promising area to infer the exact ranges of wading depths of these cranes. The ratio of tibiotarsus to tarsometatarsus of the cranes standing on the lands and the ratio of tibiotarsus to the rest of tarsometatarsus of the cranes standing in water were measured; to infer the projection depths of the part of tarsometatarsus submerged in water, which was used to calculate the accurate depth range of the cranes by comparing with the referenced values. According to the results, 89.92% of individuals preferred the water depths from (0-20]cm, 76.11% preferred (0-10]cm% while water depths for 49,04% individuals was (0-5]cm. Thus we conclude that the Black-necked Cranes prefer a depth range of (0-10]cm. This water depth may be relative to the swamps around the lake, which are very important foraging and roosting sites for cranes, For better habitat management, we strongly recommend to pay special attention to swamps with specific water depth ranges, particularly when the water level changes.
Future Changes in Precipitation Over Northern Europe Based on a Multi-model Ensemble From CMIP6: Focus on Tana River Basin
Authors: Moradian Sogol , Haghighi Ali Torabi , Asadi Maryam , Mirbagheri Seyed Ahmad
Published: October 2021

Accurate climate predictions help policymakers mitigate the negative effects of climate change and prioritize environmental issues based on scientific evidence. These predictions rely heavily on the outputs of GCMs (General Circulation Models), but the large number of GCMs and their different outputs in each region confuses researchers in their selection. In this paper, we analyzed the performance of a CMIP6 (Climate Model Intercomparison Project Phase 6) multi-model ensemble for precipitation data over Northern Europe. We first evaluated the overall performance of 12 CMIP6 models from GCMs in thirty years of 1985-2014. In addition, future projections were analyzed between 2071 and 2100 using SSP1-2.6 and SSP5-8.5 (Shared Socioeconomic Pathways). Then, simulations were statistically improved using an ensemble method to correct the systematic error of the CMIP6 models and then the capacity of postprocessed data to reproduce historical trends of climate events was investigated. Finally, the possible spatio-temporal changes of future precipitation data were explored in Tana River Basin. The results of this study show that different CMIP6 models do not have the same accuracy in estimating precipitation in the study area. However, the ensemble method can be effective in increasing the accuracy of the predictions. In addition, this study projected a change in the monthly precipitation data over Tana River Basin by 2.46% and 2.06% from 2071 to 2100 compared to the historical period, based on SSP1-2.6 and SSP5-8.5, respectively.
Recent Changes in Temperature Extremes in Subtropical Climate Region and the Role of Large-Scale Atmospheric Oscillation Patterns
Authors: Mallick Javed , Salam Roquia , Islam H. M. Touhidul , Shahid Shamsuddin , Kamruzzaman Mohammad , Pal Subodh Chandra , Bhat Shakeel Ahmad , Elbeltagi Ahmed , Rodrigues Thiago Rangel , Ibrahim Sobhy M. , I Abu Reza Md. Towfiqul
Published: October 2021

Understanding the recent variations in temperature extremes is crucial to anticipate the forthcoming incidences of extreme phenomena. However, Knowledge on temperature extremes' spatial and temporal patterns, as well as their links to atmospheric oscillation and topography, is scarce in Bangladesh. To this end, this research intends to analyze the spatial and temporal trends in recent extreme temperatures and their relationships with oscillation indices and the topography of Bangladesh. Daily temperature data obtained from 20 meteorological stations for 1980–2017 were employed for this purpose. Results revealed that the rises in summer days (SU25), tropical nights (TR20), warm days (TX90p), warmest days (TXx) and warm nights (TN90p), while declinations in coldest days (TNn), cold days (TX10p) and cold nights (TN10p) in Bangladesh. Spatial distribution of trends revealed an increase in SU25 and TN90p by 1.9–2.38, 2.33–2.90 days/decade, and a decrease in TX10p and TN10p by 1.7–3.3 days/decade in most regions. Besides, TR20 showed an increase of 3.22–4.17 days/decade in all sub-regions. The temperature extremes of Bangladesh showed a significant connection with multivariate ENSO index (MEI) and Sea Surface Temperature (SST). Besides, the extremes in most regions of the country showed a significant connection with Southern Oscillation Index (SOI) and Indian Ocean Dipole (IOD). The influence of atmospheric oscillation indices was more evident on cold days/nights than on warm days/nights. TN10p and SU25 also showed a significant correlation with elevation, suggesting an increase in cold night and summer day temperature with the increase in elevation in Bangladesh. Large-scale climate mode reanalysis revealed that a strong (weak) wind speed, enhancing (decreasing) geopotential height, and fast warming (cooling) over the northwestern (southeast) region have attributed to the variations in extreme temperature in Bangladesh to several extents. Climate change adaptation and disaster mitigation in Bangladesh will benefit from these findings.
A Crucial Interaction of p62 and Nrf2 in Mediating Metastasis of Esophageal Squamous Cell Cancer
Authors: Chen Xiuying , Yu Li , Zhou Junyang , Ren Ji , Wang Shan , Tan Yujie , Ding Yan
Published: October 2021

Background: Sequestosome 1 (SQSTM1), also referred to as p62 and nuclear factor erythroid 2-related factor 2 (Nrf2) have implicated into the pathogenesis of esophageal squamous cell carcinoma (ESCC). While p62 and Nrf2 interact and influence each other in diverse pathological settings, in whether such interaction contributes to ESCC remains unclear. In this study, we aimed to explore the functional significance of p62 and Nrf2 in ESCC, and uncover a interaction between p62 and Nrf2 in mediating ESCC.Results: Herein, we show a critican interaction betwwen p62 and Nrf2 in ESCC. Huamn GEPIA database analysis revealed the expression of p62 and Nrf2 is upregulated in ESCC, which is further verified by biochemical assessements using a human tumor tissue bank. Genetic knockdown of p62 and/or Nrf2 demonstrated a mediator role of p62 and Nrf2 in the proliferation, migration and movement ability of ECSS cells. In addition, the downregulation of p62 or Nrf2 could change the morphology of ESCC cells, transforming them from shuttle to round shape, and inhibit their EMT. The knockdown approach also reveal a synergy between p62 and Nrf2 in promoting EMT and the invasive growth of ESCC cells. The xenograft assay in vivo revealed similar effects of p62 and/or Nrf2 knockdown on tumorigenesis and metastaisis of ESCC. Conclusions: These results indicate that p62 and Nrf2 promote EMT and metastasis of ESCC in a synergistic manner. Simultaneously targeting of p62 and Nrf2 may have a therapeutic potential in treating ESCC.
The Mental Representation of Occupational Stereotypes is Driven As Much By Their Affective As By Their Semantic Content
Authors: Kocsor Ferenc , Ferencz Tas , Kisander Zsolt , Tizedes Gitta , Schaadt Blanka , Kertész Rita , Kozma Luca , Vincze Orsolya , Láng András
Published: October 2021

Background: Studies on person perception showed that stereotypes can be activated by presenting either characteristic traits of group members, or labels associated to these groups. However, it is not clear whether these pieces of semantic information activate negative and positive stereotypes directly, or via an indirect cognitive pathway leading through brain regions responsible for affective responses. To disentangle the effects of semantic and affective contents, first we intended to scrutinize whether the representation of occupational labels is independent of the emotions they evoke.Methods: Participants (N = 71, M=27.0, SD=9.1, 31 men 42 women,) were asked to complete two tasks presented online. In the first task they had to arrange 20 occupational labels—randomly chosen from a pool of 60 items— in a two-dimensional space, moving the mouse pointer along two undefined axes. In a second task the axes’ names were defined a priori. Subjects were asked to arrange the labels according to valence, the extent to which the word evoked pleasant or unpleasant feelings, and arousal, the extent to which the word evoked excitement or calmness. Results: Based on the final coordinates of the labels, two cluster analyses were carried out separately in the two tasks. The two clusters were compared with Fisher’s exact test, which revealed that the cluster structures overlap significantly.Conclusions: The results suggest that the semantic representation of occupations relies largely on the affective state they evoke. We propose that affective content might have a primacy over detailed semantic information in many aspects of person perception, including categorization and face recognition.
Efficacy of Stereotactic Body Radiation Therapy in Patients With Pd-1 Inhibitor–transarterial Chemoembolization Refractory Intermediate-stage Hepatocellular Carcinoma: a Retrospective Controlled Study
Authors: Xiang Yan-Jun , Wang Kang , Zheng Yi-Tao , Feng Shuang , Yu Hong-Ming , Li Xiao-Wei , Cheng Xi , Cheng Yu-Qiang , Wang Wei-Jun , Feng Jin-Kai , Qin Ying-Yi , Zhou Li-Ping , Meng Yan , Zhai Jian , Shan Yun-Feng , Cheng Shu-Qun
Published: October 2021

Introduction: Transarterial chemoembolization (TACE) combined with PD-1 inhibitor is a novel and effective combination therapy. However, there is currently a gap in subsequent treatment when patients are diagnosed with PD-1 inhibitors-TACE refractoriness.Methods: This retrospective cohort study included enrolled patients with intermediate stage HCC who were diagnosed with PD-1 inhibitor-TACE refractoriness between January 2019 and December 2020 in the Eastern Hepatobiliary Surgery Hospital and the First Affiliated Hospital of Wenzhou Medical University. They were divided into two cohorts, (1) those who switched from TACE combined with PD-1 to stereotactic body radiation therapy (SBRT) combined with PD-1 and (2) those who continued TACE combined with PD-1. Progression free survival (PFS), overall survival (OS), and tumor response were assessed in both groups after refractory to PD-1 inhibitors combined with TACE.Results: Of the seventy-six patients included in this study, the median PFS was 19.6 months in the SBRT group (n=31) and 10.1 months in the TACE group (n=45, p<0.05). The SBRT group also had a significant higher OS than the TACE group (p<0.05). Objective response rate (ORR) and disease control rate (DCR) were also better in the SBRT group (ORR, 71.0% vs. 15.6%, OR=8.483, 95%CI 3.319-21.680, P < 0.001; DCR, 80.6% vs. 31.1%, OR=9.226, 95%CI 3.096-27.493, P < 0.001). Conclusions: SBRT combined with PD-1 inhibitor improves PFS and OS in patients refractory to PD-1 inhibitor combined with TACE. Therefore, SBRT is recommended in case of failure of treatment with PD-1 inhibitors combined with TACE.
Interaction-driven breakdown of dynamical localization in a kicked quantum gas
Authors: Cao Alec , Sajjad Roshan , Mas Hector , Simmons Ethan , Tanlimco Jeremy , Nolasco-Martinez Eber , Shimasaki Toshihiko , Kondakci Hasan , Galitski Victor , Weld David
Published: October 2021

Quantum interference can terminate energy growth in a continually kicked system, via a single-particle ergodicity-breaking mechanism known as dynamical localization. The effect of many-body interactions on dynamically localized states, while important to a fundamental understanding of quantum decoherence, has remained unexplored despite a quarter-century of experimental studies. We report the experimental realization of a tunably-interacting kicked quantum rotor ensemble using a Bose-Einstein condensate in a pulsed optical lattice. We observe signatures of a prethermal localized plateau, followed for interacting samples by interaction-induced anomalous diffusion with an exponent near one half. Echo-type time reversal experiments establish the role of interactions in destroying reversibility. These results quantitatively elucidate the dynamical transition to many-body quantum chaos, advance our understanding of quantum anomalous diffusion, and delimit some possibilities for protecting quantum information in interacting driven systems.
Consultation Rates in People with Type 2 Diabetes with and without Vascular Complications: A Retrospective Analysis of 141,328 Adults in England
Authors: Abner Sophia , Gillies Clare L , Shabnam Sharmin , Zaccardi Francesco , Seidu Samuel , Davies Melanie J , Adeyemi Tobi , Khunti Kamlesh , Webb David
Published: October 2021

Objective
To assess trends in primary and specialist care consultation rates and average length of consultation by cardiovascular disease (CVD), type 2 diabetes mellitus (T2DM), or cardiometabolic multimorbidity exposure status.
Methods
Observational, retrospective cohort study used linked Clinical Practice Research Datalink primary care data from 01/01/2000- 31/12/2018 to assess consultation rates in 141,328 adults with newly diagnosed T2DM, with or without CVD. Patients who entered the study with either a diagnosis of T2DM or CVD and later developed the second condition during the study are classified as the cardiometabolic multimorbidity group. Face to face primary and specialist care consultations, with either a nurse or general practitioner, were assessed over time in subjects with T2DM, CVD, or cardiometabolic multimorbidity. Changes in the average length of consultation in each group were investigated.
Results
696,255 (mean 4.9 years [95% CI, 2.02-7.66]) person years of follow up time, there were 10,221,798 primary and specialist care consultations. The crude rate of primary and specialist care consultations in patients with cardiometabolic multimorbidity (N=11,881) was 18.5 (95% CI, 18.47-18.55) per person years, 13.5 (13.50, 13.52) in patients with T2DM only (N=83,094) and 13.2 (13.18, 13.21) in those with CVD (N=57,974). Patients with cardiometabolic multimorbidity had 28% (IRR 1.28; 95% CI: 1.27, 1.31) more consultations than those with only T2DM. Patients with cardiometabolic multimorbidity had primary care consultation rates decrease by 50.1% compared to a 45.0% decrease in consultations for those with T2DM from 2000-2018. Specialist care consultation rates in both groups increased from 2003-2018 by 33.3% and 54.4% in patients with cardiometabolic multimorbidity and T2DM, respectively. For patients with T2DM the average consultation duration increased by 36.0%, in patients with CVD it increased by 74.3%, and in those with cardiometabolic multimorbidity it increased by 37.3%.
Conclusions
Annual primary care consultation rates for individuals with T2DM, CVD, or cardiometabolic multimorbidity have fallen since 2000, while specialist care consultations and average consultation length have both increased. Individuals with cardiometabolic multimorbidity have significantly more consultations than individuals with T2DM or CVD alone. Service redesign of health care delivery needs to be considered for people with cardiometabolic multimorbidity to reduce the burden and health care costs.
Comparison of the Bone Cement Leakage on Vertebroplasty with High-Viscosity Cement Versus Decompressed Kyphoplasty: A Retrospective Study
Authors: Cheng Shih-Hao , Chou Wen-Hsiang , Tsuei Yu-Chuan , Sun Shih-Sheng , Au Man-Kuan , Chu William , Chu Woei-Chyn
Published: October 2021

Cement leakage is a concerning complication of percutaneous kyphoplasty or vertebroplasty, as it may lead to neurologic injury. High viscosity cement has been recently used in vertebroplasty to prevent cement leakage. In this study, we aimed to compare the results between vertebroplasty with high viscosity cement to a novel technique “decompressed kyphoplasty” that used a low viscosity cement. A total of 136 patients with a single level osteoporotic compression fracture were retrospectively included in our study. 70 patients received vertebroplasty with high viscosity cement while the other 66 patients received decompressed kyphoplasty with low viscosity cement. The overall cement leakage rate was not significantly different between the two groups (18.6% and 9.1%, p = 0.111). However, the risk of intradiscal leakage was lower for the decompressed kyphoplasty group (p = 0.011), especially when the pre-operative x-ray did not display a cleft sign. The change in the kyphotic angle and the risk of adjacent segment collapse were similar (p = 0.739 and 0.522 respectively). We concluded that decompressed kyphoplasty can reduce intradiscal cement leakage rate compared to high viscosity cement vertebroplasty. The technique is particularly useful for patient without cleft sign on x-ray to prevent intradiscal leakage.
Routine Use of DHIS2 Data: A Scoping Review
Authors: Byrne Elaine , Saebø Johan Ivar
Published: October 2021

BACKGROUND:In terms of health service planning and delivery the use of information at different levels in the health system is vital, from influencing policy, to program action, and to evidence informed practices. However, having good data or access to good data does not necessarily imply data use. For information to be used relevant data needs to be collected, processed and analysed in an accessible format. The problem of little or no data use is widespread and has been evident for decades.The DHIS2 software platform supports routine health management for an estimated 2.4 billion people and is used in over 70 countries. DHIS2 is by far the largest and most widespread software for this purpose and adopts a holistic socio-technical approach to development and implementation. With this approach and the rapid and extensive scaling of DHIS2 we questioned whether this has been matched with the increased scaling of improved information use. To date there has been no rigorous review of the documentation on how DHIS2 data is routinely being used for action and decision-making. This scoping review addresses this gap. METHODS:The five stage approach of Arksey and O’Malley and progressed by Levac et al., was followed. Three databases (PubMed, Web of Science and Embase) were searched, along with relevant conferences and postgraduate thesis. In total approx. 300 documents were reviewed with 18 documents being fully reviewed. RESULTS:Overall DHIS2 data is being used but there are few detailed descriptions of this in peer reviewed or grey literature. We find that there is commonly a centralised versus decentralised pattern of use in terms of access to data and reporting data up in the system, and that the different conceptualisations of data use and how data use is conceptualised is not made explicit. CONCLUSIONS:We conclude with some suggestions on the way forward, namely: the need to document in more detail and share how data is being used, investigating how data was created and who uses the data, designing systems based on work practices and exploring and promoting forums in which we can have ‘conversations’ around data.
Neoadjuvant Chemotherapy for Stage II–III Breast Cancer: A Single-center Experience
Authors: Zaher Haidi Abd El , Fathy Hamdad , Abozeid Mohamed , Faisal Mohammed
Published: October 2021

Introduction: We conducted this study to reflect a single-center experience with the use of neoadjuvant systemic chemotherapy for the management of women with operable breast cancer.Methods: We conducted a retrospective chart review on all women presenting with operable, stage II-III, breast cancer and were scheduled for neoadjuvant systemic chemotherapy at Suez Canal University Hospital. The primary outcome of this study was to estimate the proportion of patients with operable breast cancer who become eligible for breast conservative surgery (CBS) after neoadjuvant systemic chemotherapy.Results: A total of 147 patients were included. Before the initiation of chemotherapy, only 66 (44.9%) patients were indicated for breast conservative surgery (CBS). A total of 40 (50.6%) new patients, out of the 81 patients who were ineligible before chemotherapy, became eligible for breast conservative surgery after neoadjuvant chemotherapy (95% CI 39.3 – 61.9%). On the other hand, nine (13.6%) patients became ineligible for breast conservative surgery after neoadjuvant chemotherapy. Out of the 98 eligible patients for breast conservative surgery after chemotherapy, 72 (73.5%) patients underwent the surgery and the remaining 26 patients chose total modified radical mastectomy (MRM). A total of 55 (76.4%) patients achieved pathological complete response pCR. One woman (0.1%) experienced relapse at the 3rd year of follow-up and three women (2%) experienced relapse at the 5th year of follow-up. The difference between patients who underwent breast conservative surgery and total mastectomy was not statistically significant (p =0.22 and 0.07, respectively).Conclusion: Neoadjuvant chemotherapy can play a crucial role in increasing the rate of eligibility for breast conservative surgery among women with operable, stage II-III, breast cancer.
Paleotsunami History of Hachinohe, Northern Japan: A Multiproxy Analysis and Numerical Modeling Approach
Authors: Velasco-Reyes Erick R. , Goto Kazuhisa , Sugawara Daisuke , Nishimura Yuichi , Shinohara Takahiro , Chiba Takashi
Published: October 2021

Paleotsunami studies along the Pacific coast of Tohoku, northern Japan, have been considerably developed recently, particuvclarly after the massive impact of the 2011 Tohoku-oki tsunami. Nevertheless, in the southernmost Shimokita Peninsula, studies pertaining to paleotsunami are underdeveloped, leading to vague understanding of the tsunamigenic sources northward of the Tohoku region, along with incomplete hazard evaluation. Paleotsunami deposits in Shimokita can be related not only to the Japan trench along the Sanriku coast, but also to the Kuril trench along the Pacific coast of Hokkaido. In this study, we unveiled the paleotsunami history of Hachinohe in northern Tohoku. Using a combination of sedimentological, geochemical, paleontological, and mineralogical proxies, we characterized seven sand layers that dated from ca. 2700 to ca. 5500 yr BP based on radiocarbon (14C) ages as event deposits of marine origin. Sedimentological and paleontological evidence coupled with ground penetrating radar imagery revealed a marsh environment comprising successive extinct ponds, controlling the depositional environment. Numerical modeling ruled out the possibility of storms as genetic sources, leading to the conclusion that the presence of event deposits with marine sediments in the study area would be associated with tsunami inundation episodes. Based on 14C dating, the average frequency of recurrence of tsunamis is estimated as 545–736 years with a 2σ error range. This interval is shorter than that estimated in Harashinai, northern Sanriku Coast, near our survey site, which suggests an average of 530 to 956 years (2σ) for the same time frame. The previously recorded limited paleotsunami evidence and absence of an estimated recurrence interval in the Shimokita Peninsula reaffirms the importance of Hachinohe as a tsunami record site for the activity of both trenches.
Arsenic Contamination of Groundwater and Its Clinical Impact on Inhabitants in Central East India
Authors: Tripathi Seema , Mishra Nikhil , Jonnalagadda Sreekanth B , KUMAR ANIL
Published: October 2021

We have worked on the As concentrations present in the groundwater samples in the Rajnandgaon region of India, as well as the clinical assessment of the impact of Arsenicosis on the human population. Out of twenty groundwater samples from eight villages, arsenic was found to be above the permissible limit in eighteen samples. The people in the affected area were found suffering from diffused and spotted melanosis, diffused and nodular keratosis, leucomelanosis, hepatomegaly, and splenomegaly. The hematological parameters, viz. low Hemoglobin, high ESR, and low PCV, with RBC, WBC, and Platelet counts adversely altered and increased Prothrombin time. The change in biochemical parameters reflects the toxic effect of prolonged exposure to arsenic viz. – low Serum Glucose, high LDL, HDL, and TG, decreased Total Protein, Albumin, and Globulin. Total Bilirubin, Creatinine, Urea, and SGPT were at higher levels, but the activity of Alkaline phosphatase was found lower. The study reveals the severe health impact on humans, especially on the liver, kidney, and skin caused by arsenic toxicity in Kaurikasa village and adjoining area.