bluuebunny/crossref_metadata_2025 huggingface dataset:
Studying on the solution of fractal composite reservoir seepage model
with linear fault under elastic outer boundary
Authors: Jiang Tingrong , Zheng Pengshe , Xu Lin , Leng Lihui
Published: December 2023

In this paper, a fractal composite reservoir seepage model considering wellbore storage and skin factor is established for composite reservoirs with linear faults. The traditional three ideal external boundary conditions are generalized into elastic external boundary conditions. Through the dimensionless transformation and laplace transformation of the seepage model, combined with the mirror reflection method and the superposition principle, the similar structure solution of the dimensionless bottom hole pressure with the fault located in the inner zone and the mirror well located in the inner and outer zones is obtained by using the similar structure method. The Stehfest numerical inversion method is used to draw the typical characteristic curve of dimensionless bottom hole pressure and pressure derivative in real space, and the sensitivity analysis of the parameters is carried out. The results show that on the one hand, the distance between the fault and the production well has a great influence on the dimensionless pressure at the bottom of the well. On the other hand, the introduction of the elastic outer boundary can better describe the seepage characteristics of the reservoir and is more general. The research results are of great significance to the mining strategy of composite reservoirs, and also provide a new theoretical basis for further study of composite reservoirs with linearfaults.
Effective Tweets Classification for Disaster Crisis based on Ensemble of Classifiers
Authors: Eke Christopher Ifeanyi , Mulenga Mwenge , Phiri Musa , Al-Shamayleh Ahmad Sami , Imran Mohammad , Kwaghtyo Dekera Kenneth
Published: December 2023

In the field of disaster crisis management, the utilization of social media platforms has gained significant recognition. It helps in disseminating and gathering information during disasters, offering real-time updates on events, infrastructure damage reports, and casualty information. However, the information comes with a substantial amount of irrelevant content. Some researchers have utilized machine learning classifiers for classification, which has become ineffective. Thus, this study proposes an ensemble-based approach to disaster tweet classification, using a wide array of linguistic and word embedding features, Additionally, we investigate various supervised learning algorithms and ensemble classifiers for resolving this issue. Our findings reveal that the ensemble feature sets, specifically, the fusion of TF-IDF and word embeddings, when coupled with Bagging, achieved a classification accuracy of 98.92%. This research highlights the potential of leveraging machine learning and ensemble techniques on disaster tweet classification, providing insights for improving real-time disaster response efforts.
Role of respiratory secretion culture in surgical outcome prediction of bacterial empyema
Authors: Liu Chia-Chi , Cheng Ya-Fu , Chen Yi-Ling , Cheng Ching-Yuan , Huang Chang-Lun , Hung Wei-Heng , Wang Bing-Yen
Published: December 2023

Background: Thoracic empyema is a serious infectious disease worldwide. Video-assisted thoracoscopic surgery is strongly recommended as a treatment, and pleural fluid and tissue cultures can be obtained intraoperatively. The combination of a pleural peels tissue culture and a pleural fluid culture improves the positive culture rate. We aimed to investigate the role of respiratory secretion cultures to determine the optimal management for improving surgical outcome.Methods: This retrospective study identified 1197 patients with phase II or III thoracic empyema from our institution. Patients who underwent decortication of the pleura from April 2011 to May 2022 with a positive pleural culture were included.Results: There were 225 empyema patients with either a positive pleural fluid culture or a positive pleural peel tissue culture. Of these, 76 patients had positive respiratory secretion culture findings during hospitalization. The most common species of pathogens were Pseudomonas aeruginosa (44%), Klebsiella pneumoniae (16%), and Staphylococcus aureus (10%) in the respiratory secretion cultures and Streptococcus spp. (38%), Klebsiella pneumoniae (12%), and Staphylococcus aureus (11%) in the pleural cultures. There were 30 patients who had a common pathogen in a respiratory secretion culture and in the pleural fluid/tissue culture. Poor outcome measures were found in these patients, including the longer use of antibiotics preoperatively (19.03 ± 37.66 days versus 9.59 ± 27.09 days, p = 0.006) and a higher mortality rate during hospitalization (40.0% versus 17.4%, p = 0.002).Conclusions: The respiratory secretion culture plays an essential role in prediction of surgical outcome in bacterial empyema. Obtaining the respiratory secretion specimen promptly through proper methods helps to improve the survival of empyema patients.
InChI Isotopologue and Isotopomer Specifications
Authors: Moseley Hunter N.B. , Rocca-Serra Philippe , Salek Reza M. , Arita Masanori , Schymanski Emma L.
Published: December 2023

This work presents a proposed extension to the International Union of Pure and Applied Chemistry (IUPAC) International Chemical Identifier (InChI) standard that allows the representation of isotopically-resolved chemical entities at varying levels of ambiguity in isotope location. This extension includes an improved interpretation of the current isotopic layer within the InChI standard and a new isotopologue layer specification for representing chemical intensities with ambiguous isotope localization. Both improvements support the unique isotopically-resolved chemical identification of features detected and measured in analytical instrumentation, specifically nuclear magnetic resonance and mass spectrometry. This new extension to the InChI standard would enable improved annotation of analytical datasets characterizing chemical entities, supporting the FAIR (Findable, Accessible, Interoperable, and Reusable) guiding principles of data stewardship for chemical datasets, ultimately promoting Open Science in chemistry.
The impact of COVID-19 pandemic on financial performance: Comparison between Egyptian SMEs Tamayoz and EGX30 index
Authors: Sherif Ismail El-Halaby  , Hebatallah Ahmed Soliman  , Hussien Mohsen Ahmed
Published: December 2023

Most SMEs experience economic collapse and even insolvency due to a lack of sufficient governmental support, particularly those working in growing nations like Egypt with a heavy focus on SMEs’ growth and political and economic instability. As a result, this paper seeks first to measure the consequences of COVID-19 on financial performance (FP) by comparing small and medium enterprises (SMEs) with listed corporations in the Egyptian Stock Exchange (EGX). Second, we examine the impact of governmental interventions on this association. Our sample includes 26 SMEs in the Tamayoz EGX and the highest 30 firms listed in the EGX30. We applied pooled ordinary least square regression, paired sample test, and Barron and Kenny’s test. We used daily stock market returns from January 2020 to November 2020. The proliferation of COVID-19 has an influence on stock prices in both the EGX30 and Tamayoz stock indexes. We furthermore find a partial mediation of income support, facial-covering, school closures, and restrictions on international movements on the linkage between COVID-19 and FP for SMEs. The stock prices listed in EGX30 seem more sensitive to governmental interventions than Tamayoz EGX. The findings confirm governmental interventions would have a significant role in the firm’s FP during the COVID-19 pandemic.
Relationships between demographic factors, job satisfaction, and intention to leave among women employees in Indonesia
Authors: Febriani Rizki , Nurhasanah Siti , Rahman Hakim Arif
Published: December 2023

Job satisfaction is essential for improving company’s performance because the more satisfied employees are, the higher their work performance. The intention to leave has recently become a hot topic related to employees’ desire to leave the company. Such intentions can undoubtedly harm the company. This study aims to analyze the effect of demographic variables on employee job satisfaction and intention to leave. The sample includes 427 female employees in manufacturing companies in Indonesia. SEM-PLS with Smart-PLS software was used as the analysis method. Research findings show that demographic factors affect the intention to leave and job satisfaction. It was also found that demographic factors affect intention to leave, mediated by job satisfaction. Job satisfaction is essential in the relationship between demographic factors and employee intention to leave. This finding adds to existing insight that different demographic factors can affect employee turnover rates, such as high income, which can reduce employee intention to leave the company. Employee job satisfaction is subject to the influence of demographic factors, including age, with older employees generally expressing higher levels of job satisfaction.
Levantamento rápido de mamíferos em duas áreas antropizadas no estado de Santa Catarina, sul do Brasil
Authors: Cherem Jorge , Hadler Patrícia
Published: December 2023

O estado de Santa Catarina apresenta uma mastofauna diversificada, mas algumas áreas ainda permanecem pouco amostradas. Nesse sentido, apresentam-se aqui os resultados obtidos com o levantamento rápido de mamíferos em duas áreas antropizadas na região nordeste do estado de Santa Catarina. As amostragens ocorreram em junho e setembro de 2018 em uma área em Araquari, e em março e setembro de 2021 em uma área em Porto Belo. Foram empregados os métodos de observação direta, levantamento de vestígios (incluindo a análise de dentes e ossos de pequenos mamíferos em fezes de predadores) e armadilhas fotográficas em ambas as áreas, e captura de pequenos mamíferos com armadilhas em Araquari e entrevistas em Porto Belo. Identificaram-se 22 espécies em Araquari e 10 em Porto Belo, totalizando 27 espécies, pertencentes a 13 famílias e sete ordens de mamíferos. A lista inclui duas espécies ameaçadas (Leopardus guttulus e Puma concolor) e duas exóticas invasoras (Mus musculus e Rattus norvegicus). Foram também registradas quatro espécies domésticas, sendo dois exóticos invasores (Canis familiaris e Felis catus). Em Araquari, Oxymycterus quaestor foi o pequeno mamífero mais capturado. Cerdocyon thous foi a espécie de médio e grande porte mais comumente registrada em ambas as áreas.
“As terras do príncipe”: migrações e paisagens de Joinville (SC) em Rodowicz-Oswiecimsky e Leo Waibel (1853-1949)
Authors: Fernandes Duarte Alanna
Published: December 2023

Este artigo objetiva discutir o processo de ocupação antrópica de migrantes europeus (ou não) e o desenvolvimento da agricultura por meio da análise das obras de Rodowicz-Oswiecimsky (1992), originalmente escrita em 1853, e de Leo Waibel (1949), as quais apresentam descrições sobre as paisagens da cidade de Joinville, situada no litoral norte de Santa Catarina. O intuito é perceber como tais obras são fontes históricas que possibilitam aprofundar a noção de paisagem e como, com base nelas, podemos discernir algumas particularidades das experiências migratórias e das mudanças ambientais na então Colônia Dona Francisca (atual Joinville, SC), do século XIX até a segunda metade do século XX.
Review on Heavy Metal Removal and Efficacy of Biosorbents
Authors: Nithyanandam Rajesh , Rajendran Rupika , Rajesh Rajavarsini , Orvy Moontarij Jahan
Published: December 2023

:

Industries release a significant amount of wastewater contaminated with heavy metals.
It is a major cause of pollution and a potential health hazard when discharged into the environment
without treatment. Standard adsorbents for removing heavy metals have certain limitations,
like incomplete metal removal, high energy requirements, and undesirable waste generation.
Therefore, the use of biosorbents is an effective alternative to conventional procedures.
This critical review evaluates and summarizes the optimum results obtained from different papers
covering different parameters such as biosorbent removal efficiency and their adsorption
capacity, adsorbent dosage, and effect of pretreatment for removal of single and combination of
heavy metals. The influence of pH, contact time, and sorbent dose on biosorption has been discussed.
The Langmuir model and the Freundlich model are studied for various biosorbents, and
the respective results are obtained and summarised. The pseudo-first and second-order models
have been evaluated to study the sorption kinetics. Through this review, it can be concluded that
biosorbents can be a promising alternative to treat industrial effluents, mainly because of their
high metal binding capacity, low cost, high efficiency in diluted effluents, and environmentally
friendly nature.
Synthesis, Spectroscopic Characterization, and Adsorption Study of KOH Activated Limonia Acidissima (Kavat Shell Charcoal) for Removal of Metal Ion
Authors: Shirbhate Vaishali A. , Gulwade Deepali P.
Published: December 2023

Introduction:

Carbon is widely recognized as a unique element because of
its versatile nature resulting in its variety of applications. The adsorption process is
among the most effective techniques for the removal of many transition metal ions
from adsorbent Kavat Shell carbon (KSC).

Methods:

Activated charcoal is synthesized by a chemical activation technique using
KOH as an activating agent. The objective of this research is to study the elimination of
transition metal ion and their adsorption is discussed under various optimum experimental
conditions. Langmuir, Freundlich, and Temkin adsorption isotherms fitted to
the data well.

Results:

The important scope of this research is to prepare microporous activated carbon
from Limonia Acidissima by chemical activation and to investigate the concentration
of metal ions.

Conclusion:

Similarly, the surface morphological study was also examined via
Scanning Electron Microscopy (SEM), and functional groups were analyzed using energy
dispersive X-ray diffraction spectroscopy (XRD) and Fourier Transform Infrared
spectroscopy technique (FTIR), respectively.
Tuberculosis-related Mood Disorders: Probiotics as a Next-Generation
Strategy
Authors: Bhardwaj Ankit , Gupta Rachna
Published: December 2023

Introduction:

Tuberculosis-related mood disorders are well-known but least researched.
As frequent comorbidity of tuberculosis (TB), depression is linked to poor adherence to treatment
for a number of illnesses. The exact causal mechanism and pathways behind TB disease and associated mental illnesses are unclear. The disease's severity and duration impact the occurrence of depression, and MDR-TB enhances this risk. To summarise the information on the association between depression and unfavourable outcomes of TB treatment, we carried out a narrative review.

Objective:

The objective of this study is to provide an overview of probiotics as a cutting-edge
treatment for mood disorders linked to tuberculosis.

Methods:

A systematic stepwise online database research was done for systematic reviews, original
studies, and review papers published on probiotics and mental disorders associated with tuberculosis
in PubMed/MEDLINE, Google Scholar, and Web of Science. The reference lists for these articles
were also used as sources for the bibliography

Results:

The gut microbiota and the brain are connected by neuroendocrine-immune pathways. The
diversity and abundance of microbiota Proteobacteria, Actinobacteria Bacteroides, and Firmicutes
are reduced in tuberculosis patients. Through the stimulation of different immunological responses
or visceral sensory pathways, these changes in the gut microbiome may be a contributing factor in
emotional instability and mood disorders. Probiotics also lessen the stress response caused by cortisol, in addition to releasing neurotransmitters, including GABA, serotonin, noradrenaline, acetylcholine, and dopamine, in various brain regions. Probiotics are the most prevalent in the sensory
brain network of the brain, which controls the brain's core processing of emotions and sensations. In
addition, they produce short-chain fatty acids (SCAFs) from the bacterial fermentation of fibre in
the colon, such as butyrate, which inhibits histone deacetylase, binds to G protein-coupled receptors,
and serves as an energy metabolite. Butyrate plays a significant role in maintaining brain health by
having antimanic and antidepressant effects. Several clinical research on patients with MDD has
revealed that probiotics have favourable effects on depressive symptoms.

Conclusion:

The central dopamine system, inflammation, the BDNF system, and the gut-brain axis
are all recognised to play crucial roles in the pathogenesis of MDD. Commercial probiotics that
generate butyrate-producing SCFAs and those resistant to metabolic disorders (such as Bacteroidetes) may be beneficial for tuberculosis-related MDD during and after treatment. In this situation,
using bacteria that produce SCFA could be a cutting-edge method of treating clinical MDD.
ChatGPT in Medical Education: A Precursor for Automation Bias?
Authors: Nguyen Tina
Published: December 2023

Artificial intelligence (AI) in health care has the promise of providing accurate and efficient results. However, AI can also be a black box, where the logic behind its results is nonrational. There are concerns if these questionable results are used in patient care. As physicians have the duty to provide care based on their clinical judgment in addition to their patients’ values and preferences, it is crucial that physicians validate the results from AI. Yet, there are some physicians who exhibit a phenomenon known as automation bias, where there is an assumption from the user that AI is always right. This is a dangerous mindset, as users exhibiting automation bias will not validate the results, given their trust in AI systems. Several factors impact a user’s susceptibility to automation bias, such as inexperience or being born in the digital age. In this editorial, I argue that these factors and a lack of AI education in the medical school curriculum cause automation bias. I also explore the harms of automation bias and why prospective physicians need to be vigilant when using AI. Furthermore, it is important to consider what attitudes are being taught to students when introducing ChatGPT, which could be some students’ first time using AI, prior to their use of AI in the clinical setting. Therefore, in attempts to avoid the problem of automation bias in the long-term, in addition to incorporating AI education into the curriculum, as is necessary, the use of ChatGPT in medical education should be limited to certain tasks. Otherwise, having no constraints on what ChatGPT should be used for could lead to automation bias.
DETERMINAN PROLONGED LENGTH OF STAY (PLOS) ICU PADA PASIEN PEDIATRIK YANG MENJALANI PEMBIUSAN DI MASA PANDEMI COVID-19
Authors: Hernawan Agung Diky , Sari Djayanti , Widyastuti Yunita
Published: December 2023

Latar belakang: Di Indonesia ruang ICU dengan pemanfaatannya tidak seimbang, dikarenakan terbatasnya ruang ICU atau lamanya perawatan pasien ICU. Pelayanan ICU meliputi pasien dengan disfungsi organ atau pasien paska pembiusan khususnya pediatrik. Periode 1 maret 2020 Indonesia dilanda pandemi COVID-19. Kebutuhan ruang ICU meningkat, sebagian besar pasien terinfeksi jatuh pada kondisi gagal napas baik dewasa maupun pediatrik. Masalah yang saling berhubungan dan menjadi dasar peneliti dalam menentukan determinan PLOS ICU yaitu pasien pediatrik paska pembiusan yang membutuhkan perawatan ICU, terbatasnya ruang ICU dan masalah pandemi COVID-19.

Tujuan: Mengetahui determinan Prolonged Length of Stay (PLOS) ICU pada pasien pediatrik yang menjalani pembiusan di masa pandemi COVID-19.

Metode: Penelitian merupakan studi observasional kohort retrospektif. Sampel penelitian sebanyak 173 pasien pediatrik yang menjalani pembiusan dan perawatan paska operasi di ICU di RSUP Dr Sardjito kurun waktu April 2020 - Maret 2021. Variabel – variabel diuji menggunakan Student’s t-test untuk data numerik, Chi square test untuk data kategorikal/dikotomus. Hasil p<0,25 dilanjutkan dengan uji regresi logistik. Hasil p<0,05 dimasukan pada analisis multivariat dan dianggap bermakna.

Hasil: Faktor yang teridentifikasi sebagai determinan PLOS di ICU RSUP Dr.Sardjito adalah operasi mayor dengan nilai P 0,048 (OR 8,87), transfusi darah dengan nilai P 0,019 (OR 2,34) dan ventilasi mekanik dengan nilai P 0,010 (OR 3,44) merupakan variabel paling signifikan terhadap PLOS di ICU dengan nilai p<0,05.

Kesimpulan: Operasi mayor, transfusi darah dan ventilasi mekanik/ventilator merupakan determinan PLOS di ICU RSUP Dr.Sardjito pasien pediatrik yang menjalani pembiusan di masa pandemi COVID-19
Anesthesia-Related in Recovery Room Complication: Coma and Delayed Emergence
Authors: Siti Chasnak Saleh
Published: December 2023

Pada saat ini anestesi sudah dianggap sebagai tindakan yang aman, karena penyulit pascaanestesi yang serius dan berkaitan langsung dengan anestesi (seperti koma dan kematian) jarang detemukan.Data dari Amerika Serikat menunjukkan bahwa setiap hari hampir 60.000 pasien yang mendapat anestesi umum untuk tindakan pembedahan. Mortalitas perioperatif yang pada era sebelum tahun 1970 diperkirakan 1,06% turun menjadi 0,12% di era 1990-2000 an. Pemanjangan proses pulih sadar bahkan sampai koma, merupakan penyulit yang menggugah perhatian dokter anestesi. Data tahun 2005 menunjukkan bahwa angka kejadian koma pascaanestesi sebesar 0,5%. Berbagai penyebab dapat ditengarai berpengaruh terhadap pemanjangan proses pulih sadar, yang terutama berupa efek farmakologik obat, interaksi dari obat pelumpuh otot, dan adanya gangguan endokrin. Penyebab yang sering dihadapi dokter anestesi berupa adanya sisa pelumpuh otot, obat-obat depresi SSP, hipoksemi, hiperkarbi, hipotensi, hipotermi, hipoglikemi, hiperglikemi, dan gangguan keseimbangan elektrolit dan asam-basa. Pengelolaan dan monitoring anestesi diharapkan dapat meminimumkan penyulit tersebut. Namun untuk mengatasi hal tersebut, maka ketiga faktor harus dianalisis secara bersamaan.
TERAPI OKSIGEN HIPERBARIK
Authors: Synthana Meta Restu , Wisudarti Calcarina Fitriani Retno , Pratomo Bhirowo Yudo
Published: December 2023

Terapi oksigen hiperbarik merupakan terapi dengan memberikan 100% oksigen pada dua sampai tiga kali dari tekanan pada level air laut. Terapi oksigen hiperbarik efektif dalam mengatasi berbagai penyakit antara lain luka karena trauma akut, ulserasi yang tidak membaik dengan terapi, crush injury, luka bakar, gas gangren, dan sindrom kompartemen dapat pula digunakan pada kasus-kasus keracunan gas misal keracunan gas karbonmonoksida. Terapi oksigen hiperbarik memiliki komplikasi dan efek toksik karena hiperoksia. Terapi ini sering digunakan pada pasien-pasien kritis misal karena keracunan karbonmonoksida, luka bakar, gas gangren, abses intrakranial, emboli, sehingga klinisi khususnya anestesiologist perlu mengetahui mekanisme, efek serta komplikasi terapi oksigen hiperbarik.
PERIOPERATIF OPERASI MATA PADA PEDIATRIK
Authors: Jufan Akhmad Yun , Sari Djayanti , Wibowo Adi
Published: December 2023

Pada mayoritas kasus anak - anak membutuhkan anestesi umum untuk prosedur mata dan operasi. Tehnik anestesi yaitu mencegah dan menjaga terjadinya peningkatan tekanan intra okuler bola mata, yaitu dengan smoth induction dan smoth intubation, alternatif lain adalah dengan menggunakan Laringeal Mask Airway (LMA) untuk prosedur yang sederhana. Oculocardiac refleks dapat terangsang selama operasi mata dan risiko menyebabkan efek berbahaya bradycardi, yang dapat dicegah dengan premedikasi dengan agen antikolinergik. Mual pasca operasi dan muntah sering terjadi setelah operasi mata pada anak-anak dan mungkin pemberian profilaksis antiemetik. Pada kasus operasi tertentu mungkin sangat nyeri seperti evisceration, enucleation dan operasi vitroretinal pertimbangan pemberian analgetik dengan opioid seperti fentanyl dapat dipertimbangkan.
Pemberdayaan Petani Melalui Penyuluhan dan Pembuatan Pupuk Organik untuk Meningkatkan Sektor Pertanian serta Mendukung Pertanian Berkelanjutan di Kismantoro, Kabupaten Wonogiri
Authors: Qardhawi Ikhsan
Published: December 2023

Kecamatan Kismantoro, Kabupaten Wonogiri, Jawa Tengah merupakan daerah yang memiliki iklim tropis dan terletak pada dataran tinggi yang didominasi oleh lahan pertanian kering di bagian perbukitan dan lahan basah di bagian lembah, serta masih banyak area hutan. Hal tersebut menyebabkan sektor pertanian menjadi sumber mata pencaharian utama penduduk di Kecamatan Kismantoro. Selain pertanian, sektor peternakan khususnya sapi dan kambing juga banyak dikembangkan terutama di Desa Lemahbang dan Pucung. Potensi dari hasil pertanian dan peternakan di kedua desa tersebut cukup besar sehingga pertanian dan peternakan menjadi salah satu sektor unggulan di desa tersebut. Dalam rangka mengoptimalkan pengelolaan pertanian dan peternakan di Desa Lemahbang dan Pucung, Tim KKN-PPM UGM melakukan program kerja berupa penyuluhan dan pembuatan pupuk organik. Bahan dasar pupuk organik yang mudah diperoleh, biaya yang rendah, serta pembuatannya yang mudah dilakukan dapat menjadi nilai ekonomis yang potensial bagi para petani dan peternak rumahan. Tujuan program ini adalah membantu pengoptimalan produksi pupuk organik untuk meningkatkan pengembangan sektor pertanian serta mendukung pertanian berkelanjutan di Kecamatan Kismantoro. Metode yang digunakan dalam kegiatan ini yaitu pengambilan data dengan tiga cara, yakni observasi, wawancara, dan pencatatan. Selain itu, pengambilan sampel dilakukan dengan metode purposive sampling dan teknik analisis data dilakukan dengan deskripsi kualitatif. Pada program ini, dilaksanakan penyuluhan dan bimbingan teknis pembuatan pupuk organik cair Jakaba (Jamur Keberuntungan Abadi) berbahan dasar air leri, pupuk organik cair berbahan dasar limbah rumah tangga, serta pupuk organik padat berbahan dasar kotoran ternak. Produk yang dihasilkan dari program ini yakni pupuk organik yang siap diaplikasikan pada tanah maupun tanaman. Ilmu dan pengetahuan yang diberikan dalam kegiatan ini juga dapat diterapkan dan dipraktikkan langsung secara mandiri maupun kolektif oleh masyarakat sehingga dapat mengoptimalkan sektor pertanian Kecamatan Kismantoro serta dapat mendukung pertanian yang berkelanjutan. Dengan demikian, program ini secara tidak langsung dapat meningkatkan kesejahteraan masyarakat khususnya di Kecamatan Kismantoro.
Pharmacology of Tyrosine Kinase Inhibitors
Authors: Hulin Anne , Gelé Thibaut , Fenioux Charlotte , Kempf Emmanuelle , Sahali Dil , Tournigand Christophe , Ollero Mario
Published: December 2023

Tyrosine kinase inhibitors (TKI) have introduced a significant advancement in cancer management. These compounds are administered orally, and their absorption holds a pivotal role in determining their variable efficacy. They exhibit extensive distribution within the body, binding strongly to both plasma and tissue proteins. Often reliant on efflux and influx transporters, TKI undergo primary metabolism by intestinal and hepatic cytochrome P450 enzymes, with nonkidney clearance being predominant. Owing to their limited therapeutic window, many TKI display considerable intraindividual and interindividual variability. This review offers a comprehensive analysis of the clinical pharmacokinetics of TKI, detailing their interactions with drug transporters and metabolic enzymes, while discussing potential clinical implications. The prevalence of kidney conditions, such as AKI and CKD, among patients with cancer is explored in their effect on TKI pharmacokinetics. Finally, the potential nephrotoxicity associated with TKI is also examined.
El AB“Y” de la fosforilación de tirosinas en bacterias: descripción de las enzimas implicadas y su impacto en la fisiología procarionte
Authors: Andrade Ángel , Alonso Óscar M. , Tavares-Carreón Faviola
Published: December 2023

La fosforilación de proteínas en residuos de serina, treonina y tirosina representa un paradigma central de la señalización celular. No obstante, en procariontes esta modificación postraduccional (MPT) fue desestimada durante varias décadas. Diversos estudios fosfoproteómicos bacterianos, así como la identificación y caracterización exhaustiva de las enzimas responsables de la fosforilación de proteínas en estos organismos ha derivado en una nueva visión del alcance regulatorio asociado a esta MPT. En particular, esta revisión se centra en la fosforilación en residuos de tirosina, las enzimas cinasas y fosfatasas implicadas en este proceso, su mecanismo de acción y el impacto de su actividad sobre la fisiología bacteriana.
Citizen Responsibility for Structural Corruption
Authors: Fragoso Lugo Lucero
Published: December 2023

The purpose of this essay is to explain what kind of responsibility citizens should assume for structural corruption. To delve into this topic, we analyze the components of a concept of structure as applied to the features of corruption, as well as the notions of guilt, responsibility and political responsibility. Thus, we argue that citizens who do not participate directly in acts of bribery are politically responsible for systemic corruption. Assuming political responsibility implies taking actions in the public sphere to combat the structure of corruption in conjunction with other citizens.
Jürgen Habermas. Baedeker de su propuesta jurídica
Authors: Moreno Cruz Rodolfo
Published: December 2023

Habermas ha elaborado una teoría jurídica a partir de su filosofía de acción comunicativa. Sin alejarse de los fundamentos tradicionales que sustentan al Estado democrático de derecho, ha innovado una posición de legitimación al derecho y a su ejercicio, incluso ofrece nuevas herramientas conceptuales para la función judicial, como es el caso de lo que podría llamarse la adecuación que sustituye a la conocida propuesta de la ponderación de los derechos. El presente artículo pretende servir de guía para adentrase en el territorio de su propuesta.
Sign Language Detection
Authors: Titarmare Mohit , Wankar Gaurav , Thapliyal Gaurav , Raut Yash , Sheikh Dr. Rahila
Published: December 2023

Abstract: Sign language is a crucial means of communication for individuals with hearing impairments, serving as a rich and expressive form of language. As the world becomes increasingly interconnected, there is a growing need for technology to facilitate effective communication between sign language users and the broader community. Sign language detection, a branch of computer vision and artificial intelligence, plays a pivotal role in bridging these communication gaps. This abstract provides an overview of the key aspects related to sign language detection. The primary focus is on the technological advancements and applications that contribute to the seamless integration of sign language into various aspects of daily life. The paper explores the challenges associated with recognizing and interpreting sign language gestures, considering factors such as variations in signing styles, lighting conditions, and diverse signing communities. The proposed paper delves into the methodologies employed in sign language detection systems, including image and video processing techniques, deep learning algorithms, and sensor technologies. It highlights the significance of dataset diversity and the role of machine learning in enhancing the accuracy and robustness of sign language detection models. Additionally, the paper discusses the potential integration of sign language detection into mainstream devices, applications, and assistive technologies to empower individuals with hearing impairments.
Entre tempos, identidades e (trans)territorialidades
Authors: Klausberger Marcos Irineu
Published: December 2023

Neste texto, prospectado sob a égide dos estudos fronteiriços, com enfoque maior no campo da Geografia, reflete-se sobre as cidades-gêmeas de Santana do Livramento, no Brasil, e Rivera, no Uruguai, com base em três frentes de trabalho: 1) a distinção entre os conceitos de limite e fronteira; 2) o exame das origens históricas que marcam o processo de formação dessas cidades e da área que em torno delas se constituiu; 3) as implicações das dinâmicas políticas, econômicas e culturais nas práticas cotidianas de seus habitantes. Do interior desses movimentos, evidencia-se a fronteira como uma totalidade, como um lugar social vivido e redimensionado em seus aspectos simbólicos e imaginários, representado por interações baseadas na cidadania, na binacionalidade, no trânsito diário e nas necessidades da comunidade local.
Propriedade régia e instabilidade climática
Authors: Silva André Filipe Oliveira da
Published: December 2023

O reinado de D. Afonso IV foi um período de intensa ação régia, com uma expansão notável do oficialato régio, conflitos jurisdicionais importantes e intervenção em todos os níveis de administração da res publica portuguesa. A análise da ação dos oficiais régios em tempo de profundas alterações climáticas revela-nos, contudo, uma notável flexibilidade e uma simbiose com o interesse de foreiros e lavradores, contribuindo para um aparente esbatimento das consequências de condições ambientais adversas.
Science communication as interdisciplinary training
Authors: Wood Matthew
Published: December 2023

Science communication education has come a long way thanks in part to broad recognition of the importance of communication skills and the capacity for science communication courses to address that need. Similarly, the current rise in demand for interdisciplinary competencies offers new opportunities for the advancement of science communication education, and for greater contribution to preparing graduates for a rapidly changing world.
Science communication in higher education: global perspectives on the teaching of science communication
Authors: Roche Joseph , Land-Zandstra Anne M. , Lewenstein Bruce V. , Massarani Luisa
Published: December 2023

This special issue focuses on the global landscape of teaching science communication in higher education. Following an open call, we selected seven papers with topics including the geographical distribution of science communication programmes, indicators of quality, programme analysis, self-reporting tools, interdisciplinarity, sustainability, and competencies. Collectively, these contributions highlight how the field has grown and increased in complexity, and highlights challenges faced by educators and the significance of addressing them within local and global contexts.
Law Enforcement Against The Perpetrator of Physical Violence in The Healthcare Service Environment
Authors: Kurnia Perkasa Novian
Published: December 2023

Health workers often experience physical violence in carrying out their work. The research aims to determine the extent to which legal protection applies to health workers. The data used in this research was taken from several hospitals and other health services. The method used is a case study with a qualitative approach involving several parties involved in implementing legal protection for health workers. Legal protection for health workers who experience physical violence while working in health services is regulated in several laws, namely Law Number 36 of 2014 concerning Health, Law Number 29 of 2004 concerning Medical Practice, Law Number 38 of 2014 about health. Nursing, Law Number 4 of 2014 concerning Midwifery. Apart from that, there are still many obstacles and challenges in its implementation. In conclusion, legal protection for health workers who experience physical violence in carrying out their duties in the health service environment is very important and must be provided firmly.
Desenvolvimento de um complexo diagnóstico para o estudo das tradições de educação familiar
Authors: Lykova Irina , Mayer Aleksey , Shestakova Oksana , Voinova Alena
Published: December 2023

O objetivo do estudo consiste em identificar as abordagens científicas e sistematizar os métodos de investigação para o estudo das tradições de educação familiar. Os autores analisam 43 fontes de literatura cultural, sociológica, pedagógica, psicológica e linguística. A análise interdisciplinar mostra uma contradição entre a presença de uma multiplicidade de métodos de investigação das tradições de educação familiar e a falta de um instrumento universal para obter dados objectivos sobre a essência e as especificidades da educação familiar. Para resolver esta incoerência, os autores desenvolvem um instrumento de investigação - o complexo de diagnóstico "Tradições de educação familiar". O complexo de diagnóstico permite objetivar os resultados da investigação sobre a relação entre as tradições familiares e as tradições de educação familiar e pode servir de base para o desenvolvimento de tecnologias sócio-pedagógicas de apoio à educação familiar através do reforço e/ou da restauração das tradições familiares.
Metformin: A Potential Treatment for Acne, Hidradenitis Suppurativa and Rosacea
Authors: Cho Minah , Woo Yu Ri , Cho Sang Hyun , Lee Jeong Deuk , Kim Hei Sung
Published: December 2023

Metformin is a widely used drug for treatment of diabetes mellitus, due to its safety and efficacy. In addition to its role as an antidiabetic drug, numerous beneficial effects of metformin have enabled its use in various diseases. Considering the anti-androgenic, anti-angiogenic, anti-fibrotic and antioxidant properties of metformin, it may have the potential to improve chronic inflammatory skin diseases. However, further evidence is needed to confirm the efficacy of metformin in dermatological conditions, This review focuses on exploring the therapeutic targets of metformin in acne vulgaris, hidradenitis suppurativa and rosacea, by studying their pathogeneses.
Increased Rates of Gold and Acrylate Allergy in Individuals with Fibromyalgia Tested with an Extended Dental Patch Test Series
Authors: Hopkins Katharine , Antelmi Annarita , Dahlin Jakob , Olsson Karin , Svedman Cecilia , Åstrand Jacqueline , Bruze Magnus
Published: December 2023

Fibromyalgia is a common chronic pain condition. Rates of contact allergy in individuals with fibromyalgia have not been widely studied. Systemic contact allergy can present with muscle and joint pain and general malaise. The aim of this study is to investigate contact allergy rates in individuals with fibromyalgia to the sensitizers in an extended dental series and compare with control groups. Contact allergy to gold was significantly more common in the fibromyalgia group than the dermatitis control group. When corrected for patch test system, contact allergy to gold was significantly more common in the fibromyalgia group than the dental control group. Contact allergy to hydroxyethyl methacrylate and grouped acrylates and methacrylates was significantly more common in the fibromyalgia group than the dental control group. In conclusion, individuals with fibromyalgia may have a propensity to sensitization to gold, either via an increased exposure or an alteration in the oral environment. Gold is also implicated in systemic contact dermatitis and may be a factor in elicitation of symptoms in individuals with fibromyalgia. Acrylate allergy is also common in the fibromyalgia population and may be a consequence of occupational exposure or dental treatment.
The Western Arctic – Tariuq (Offshore) Accord: A Long Time Coming
Authors: Rayegani Anita
Published: December 2023

On 10 August 2023, representatives of the Inuvialuit Regional Corporation and the governments of the Northwest Territories, Yukon, and Canada signed the Western Arctic–Tariuq (Offshore) Accord.1 The Accord establishes a system for the shared management and regulation of offshore petroleum resources north of the Arctic Circle, west of Nunavut to the limit of Canada’s jurisdiction in the Beaufort Sea and Arctic Ocean and the equitable sharing of benefits. Upon the consent of all Parties, implementing legislation will be introduced to establish the Accord and will, among other things, amend or replace relevant federal legislation. The Accord is a step towards Canada’s implementation of the United Nations Declaration on the Rights of Indigenous Peoples.2 It is also part of a quest for meaningful participation dating back to the initial activities concerning oil and gas in the region that fuelled negotiations leading to the Inuvialuit Final Agreement. This contribution situates the Accord in the context of these developments to illuminate its potential significance.
“Falar de coração para coração”
Authors: Matos Maria Izilda Santos , Tanagino Pedro Ivo Dias
Published: December 2023

Este artigo se concentra na análise das matrizes do pensamento político do intelectual português António Sardinha, particularizando sua fase republicana, período anterior à sua adesão ao movimento do Integralismo Lusitano. Objetiva-se analisar a identificação do autor com o republicanismo como parte de uma atitude de “rebelião cultural” que caracterizou uma geração de intelectuais de direita portuguesa. A pesquisa priorizou a correspondência de António Sardinha para sua noiva Ana Júlia Nunes da Silva, nos anos entre 1910 e 1912.
МЕТОДЫ (АЛГОРИТМ) ОЦЕНКИ ГИГИЕНИЧЕСКОЙ БЕЗОПАСНОСТИ ВОДОЕМОВ, СОДЕРЖАЩИХ ТОКСИНЫ СИНЕ-ЗЕЛЕНЫХ ВОДОРОСЛЕЙ
Authors: Гусев Юрий , Иванов Дмитрий
Published: December 2023

Токсические эффекты сине-зеленых водорослей на диких животных, пьющих воду из австралийского озера впервые описаны в статье Джорджа Фрэнсиса в 1878 году [1]. Токсины могут синтезировать морские, почвенные и пресноводные цианобактерии и их часто обнаруживают в источниках водоснабжения населения, в воде для полива сельскохозяйственных культур и в растениях [2,3].
В настоящее время проблема «цветения» водоемов стала более актуальной в связи с глобальным потеплением, когда рост водорослей значительно усиливается [4]. «Цветение водоемов» обычно более выражено в августе и наблюдается во многих регионах России. Помимо источников питьевого водоснабжения, оценка качества воды актуальна и в рекреационных водоемах, которые население использует для отдыха и туризма. В летний период в открытой зоне Саратовского водохранилища отмечено преобладание представителей отдела сине-зеленых водорослей, которые составляли около 74% от общей численности [5].
По химической структуре цианобактериальные токсины в основном подразделяются на циклические пептиды, алкалоиды, липопептиды, небелковые аминокислоты и липогликаны [6]. Многие из них обладают достаточной устойчивостью к физическим факторам, а также способны аккумулироваться в организмах водной экосистемы. Все это создает значительные риски для здоровья населения. Поэтому Всемирная организация здравоохранения в 1997 году установила гигиенический норматив в питьевой воде для токсина микроцистина-LR, который синтезируют различные виды цианобактерий [7].
В последние годы в России врачи-гигиенисты все чаще обращают внимание на проблему оценки рисков для здоровья, связанную с токсинами цианобактерий различных источников водоснабжения населения [8,9,10]. Однако считать данную проблему в России полностью решенной нельзя. Особенно это относится к контролю рекреационных водоемов и источников водоснабжения в малых городах и селах.
Целью настоящей статьи является обзор современных методов оценки гигиенической безопасности водоемов, содержащих токсины сине-зеленых водорослей.
Reimagining Healthcare Workers and COVID-19 in Demotivational Posters During Pandemic
Authors: Gukosyants O. Yu.
Published: December 2023

The study examines the metaphors presented in demotivational posters during the COVID-19 pandemic. Images related to healthcare workers and the coronavirus infection are identified. The iconic (and less frequently verbal) components of the demotivational posters are analyzed, which explicitly convey the author’s assessment of these objects and model their perception by the audience. The most frequent metaphors identified in the study include ‘virus as a monster’, ‘virus as a criminal’, ‘virus as a swamp’, ‘virus as shackles’, and ‘virus as a trap’ to represent the COVID-19 infection. Metaphors such as ‘doctor as a warrior’, ‘doctor as a superhero’, ‘doctor as a champion’, ‘doctor as a disinsector’, ‘doctor as a builder’, and ‘doctor as a guardian angel’ are used by the authors of the demotivational posters to represent healthcare workers. By demonstrating these metaphorical characteristics of the objects, the authors of the demotivational posters model the desired perception of these objects by the audience, emphasizing the speed of disease spread, its devastating impact, the importance of adhering to quarantine measures, and expressing gratitude and appreciation to healthcare workers for their selfless work and for saving patients’ lives.
Linguosemiotic Mechanisms of Manipulative Potential Formation in Polycoded Nomination in Advertising Discourse
Authors: Zakharov R. I.
Published: December 2023

The article is dedicated to the linguo-semiotic analysis of the functioning of polycode names as a manipulative tool in advertising discourse. The aim of the study is to describe the influence of non-verbal components on the expression of the illocutionary force of the name. The material of the study consists of polycode commercial designations identified through the author’s own internet monitoring and direct observation from 2021 to 2023. An examination of the situational context has been conducted, dominant signs in the structure of nomination have been identified, and the expressed meaning has been established. Word-formation models for creating names have been identified, classified according to the means of expressing illocutionary force. The use of similar models by commercial organizations from different fields of activity allows us to speak about the main trends in naming in advertising discourse. The author puts forward a projective hypothesis of manipulative influence: a stimulus-response situation is applied in advertising communication, and manipulation is realized through the tactic of imposition. It has been established that different situations are implicitly related in the message, for which loosely structured stimuli are used, which influence the formation of the addressee’s attitudes and program their behavior. It is concluded that in polycode commercial nominations, the technique of exploiting linguistic and non-linguistic behavioral stereotypes is used.
Unadapted Foreign Language Insertions in Spoken Language of Tundra Yukaghir
Authors: Kurilova S. N.
Published: December 2023

The foreign language insertions in the language of the tundra Yukagirs-polyglots of the Lower Kolyma in Yakutia are considered for the first time. The relevance of the study is primarily dictated by the lack of research on contact phenomena in the Yukagir language as a whole, the decreasing number of speakers, and the importance of documenting this ancient language of Northeast Siberia. The goal of the study is to identify the functioning features of insertions in the modern spoken language of the tundra Yukagirs. The material consists of recordings of oral speech by Yukagirs in the form of polylogue, dialogue, and monologue, fragments of transcripts of which are introduced into scientific circulation for the first time. The analysis shows that insertions in Yukagir speech are realized through Yakut and Russian insertions, originating from various parts of speech of the guest languages. The author concludes the relevance of the Yakut language as the second language after the ethnic one, due to the higher frequency of Yakut elements in Yakut speech compared to Russian ones. It has been established that insertions are marked by empty and filled pauses, vocal, lexical-semantic, and paralinguistic hesitations. It is noted that the creative function is realized through the manner of using insertions by individual Yukagir polyglots in their speech.