bluuebunny/crossref_metadata_2025 huggingface dataset:
API Entity and Relation Joint Extraction from Text via Dynamic Prompt-tuned Language Model
Authors: Huang Qing , Sun Yanbang , Xing Zhenchang , Yu Min , Xu Xiwei , Lu Qinghua
Published: July 2023

Extraction of Application Programming Interfaces (APIs) and their semantic relations from unstructured text (e.g., Stack Overflow) is a fundamental work for software engineering tasks (e.g., API recommendation). However, existing approaches are rule based and sequence labeling based. They must manually enumerate the rules or label data for a wide range of sentence patterns, which involves a significant amount of labor overhead and is exacerbated by morphological and common-word ambiguity. In contrast to matching or labeling API entities and relations, this article formulates heterogeneous API extraction and API relation extraction task as a sequence-to-sequence generation task and proposes the API Entity-Relation Joint Extraction framework (AERJE), an API entity-relation joint extraction model based on the large pre-trained language model. After training on a small number of ambiguous but correctly labeled data, AERJE builds a multi-task architecture that extracts API entities and relations from unstructured text using dynamic prompts. We systematically evaluate AERJE on a set of long and ambiguous sentences from Stack Overflow. The experimental results show that AERJE achieves high accuracy and discrimination ability in API entity-relation joint extraction, even with zero or few-shot fine-tuning.
Insights into Plastic Localization by Crystallographic Slip from Emerging Experimental and Numerical Approaches
Authors: Stinville J.C. , Charpagne M.A. , Maaß R. , Proudhon H. , Ludwig W. , Callahan P.G. , Wang F. , Beyerlein I.J. , Echlin M.P. , Pollock T.M.
Published: July 2023

Advanced experimental and numerical approaches are being developed to capture the localization of plasticity at the nanometer scale as a function of the multiscale and heterogeneous microstructure present in metallic materials. These innovative approaches promise new avenues to understand microstructural effects on mechanical properties, accelerate alloy design, and enable more accurate mechanical property prediction. This article provides an overview of emerging approaches with a focus on the localization of plasticity by crystallographic slip. New insights into the mechanisms and mechanics of strain localization are addressed. The consequences of the localization of plasticity by deformation slip for mechanical properties of metallic materials are also detailed.
Electrodeposition of Reactive Aluminum-Nickel Coatings in an AlCl3:[EMIm]Cl Ionic Liquid Containing Nickel Nanoparticles
Authors: del Carmen Mejia María , Graske Marcus , Winter Andreas , Baumer Christoph , Stich Michael , Mattea Carlos , Ispas Adriana , Isaac Nishchay A. , Schaaf Peter , Stapf Siegfried , Jacobs Heiko O. , Bund Andreas
Published: July 2023

The electrodeposition of aluminum-nickel coatings was performed by pulsed direct current in the ionic liquid (IL) 1.5:1 AlCl3:EMIm]Cl containing nickel nanoparticles (Ni NPs), for reactive dispersion coating application. Several electrochemical and characterization techniques were used to shed more light on the mechanism of Ni particle incorporation into the Al matrix. Thus, particle incorporation at the early stage of the deposition would mainly take place via particle adsorption at the substrate. However, as the thickness of the coating increases, it seems that the main mechanism for particle incorporation is via the reduction of

Al

2

Cl

7

−

ions adsorbed at the particles surface. Although a considerable high incorporation of Ni NPs has been achieved from the IL containing the highest concentration of Ni NPs (i.e. ∼33 wt% from a 20 g/L of Ni NPs bath), a high concentration of NPs in the IL resulted having a negative effect in terms of quality of the coatings, due to solidification of the electrolyte in a poorly conductive compound. Moreover, almost equivalent amounts of Ni and Al (Ni ∼45 wt.%and Al ∼44 wt.%) have been detected in some areas of the coatings. Such a layer composition would be desired for the targeted application.
Effect of Remineralization Pretreatments on Human Dentin Permeability and Bond Strength
Authors: Abu Hasna Amjad , Martinho Frederico Canato , Sellan Pablo Lenin Benitez , Pampuri Camila Reis , Torres Carlos Rocha Gomes , Pucci Cesar Rogério
Published: July 2023

This study aimed to evaluate Nd:YAG laser, calcium phosphate, and adhesive system effect as different pretreatments in different protocols on dentin permeability (DP) and bond strength (BS). Fifty human dentin discs were used (4 mm in diameter and 1,5 mm in height). Specimens were divided into five groups (n = 10): (A): adhesive system (control); (AL): adhesive system + Nd:YAG laser; (LAL): Nd:YAG laser + adhesive system + Nd:YAG laser; (PAL): calcium phosphate-based dentin desensitizer TeethMate + adhesive system + Nd:YAG laser; and group (PLAL): Nd:YAG laser + calcium phosphate-based dentin desensitizer + adhesive system + Nd:YAG laser. All materials were used according to the manufacturers’ instructions. The specimens were submitted to artificial aging (5,000 thermal cycles and 12 × 104 mechanical cycles) then a bond test was performed. DP was measured using the split chamber model. Data were submitted to one-way analysis of variance (ANOVA), paired t-test, RM ANOVA, and Tukey test (

p
<
0.05

). All treatments were effective in DP reduction. For BS, the groups PAL and PLAL had improved BS with a statistically significant difference of the control group (A). Nd:Yag laser irradiation and calcium phosphate-based desensitizing agents significantly reduced DP, and the association between them could improve the BS on resin–human dentin interface.
Heterogeneity in the Preferences of Potential Users of Automated Transit Network (ATN)
Authors: Kohandel Shirazi Ardeshir , Andreasson Ingmar , Afshar Farshid , Kohandel Shirazi Ashkan , Mokhtarian Hamidreza
Published: July 2023

Many cities in Iran, including the metropolis of Shiraz, are increasingly car-oriented, resulting in traffic congestion and related issues. Considering the current conditions of Iran, an automated transit network (ATN) can be one of the available solutions to this problem. ATN is an advanced type of public transit consisting of automated vehicles moving passengers on a network of dedicated guideways. As a combination of public, personal, and private transport, ATNs may decrease the use of cars and address related problems. In order to design effective policies aimed at achieving the benefits of ATN, it is necessary to have a better understanding of how people accept an ATN system, especially car users. This research aims at advancing future research on the effects of ATNs on travel behavior through identifying the characteristics of users who are likely to accept ATN services, by examining the heterogeneity in the preferences of these people. To achieve this goal, a stated choice survey was conducted and analyzed using multinomial logit (MNL) and mixed logit (ML) models. The results showed that the parameters of trip purpose, owning a hybrid car, and the level of education affect the preferences toward the ATN system. Additionally, from the comparison of the results of the MNL and ML models, it was found that despite the greater ability of the ML model in estimating possible heterogeneities, likely the MNL model can also help to record some heterogeneities more realistically. In the end, the methodological limitations of the study were also acknowledged. Despite the potential hypothesis bias and the status quo bias, the results captured the directionality and relative importance of the attributes of interest.
Hardware Obfuscation Based Watermarking Technique for IPR Ownership Identification
Authors: Bagul Priyanka , Inamdar Vandana
Published: July 2023

As the reuse of IP cores or the development of frequently used hardware modules is gaining more attention in the semiconductor industry, the misappropriation of the owner’s identity is a rising concern. Therefore, imprinting the owner’s identity in the form of a watermark or signature on the IP core is essential to avoid intellectual property right (IPR) infringement. In view of this, a watermarking technique is proposed in the present manuscript. A constraint-based dynamic watermarking method to generate the owner’s signature is proposed in conjunction with the logic encryption-based hardware obfuscation method. The method formulated in this manuscript consciously makes use of a basic switching component for embedding a watermark with IP core and hardware obfuscation, to achieve a lower overhead budget. Through the switching mechanism, the embedded watermark can be made detectable to legitimate end users off chip via test pin. The logic encryption-based method is set for accessing the watermark. Furthermore, an encrypted functionality is set as the signature generator module for generating owner’s signature. This provides hardware obfuscation and two-stage authentication mechanism for the generation of owner’s signature, and as a result of this, double-layer protection is achieved. Furthermore, a novel method to configure input key for signature generation module and to formulate owner’s signature is proposed. The viability of the present watermark technique for real-life application is checked on the ground of transparency, security, reliability, performance overhead, and robustness. Since the watermark in the proposed method is embedded outside the IP core, it does not cause any latency for the IP core functionality. Thus, even with significantly lower area overhead (∼<1.4%), the proposed method is able to provide higher robustness in terms of lower probability of coincidence (PC = 4.68 e − 97).
A Visualized Method of Airflow between Adjacent Zones inside a Multizone Building Based on Pressure Difference Frequency: Airflow Mapping
Authors: Jing Jiajun , Lee Dong-Seok , Joe Jaewan , Kim Eui-Jong , Cho Young-Hum , Jo Jae-Hun
Published: July 2023

The airflow movement inside a multizone building has a significant impact on pollutant transfer, thermal comfort, and indoor air quality. However, there are difficulties in visualizing the airflow movement with existing methods. This study proposes a visualization method for evaluating airflows between adjacent internal zones inside a multizone building based on the analysis of pressure difference frequency. After the distribution of absolute pressure is measured and the wind pressures on the surfaces of the building are calculated, the variation of pressure differences between each couple of adjacent zones is analyzed for three levels: greater than 0 Pa, equal to 0 Pa, and less than 0 Pa (for any given zones selected as target zones). Finally, an airflow mapping is created for each floor using the visNetwork tool based on the R language. A target building was selected for applying the proposed method. The airflow mappings were derived from a detailed analysis of the pressure difference frequency between each couple of adjacent zones, presenting the variations of airflow direction and the dominant airflow during the measurement period in a visualized form. For example, the airflow direction from 1F_Z2 to 1F_Z3 is 92.0%. The spatial similarity in the variations of the airflow directions can also be observed on certain floors. The results of this experimental study show that the airflows between multiple zones can be easily identified without a complex building zone analysis. The variation in internal airflow direction between adjacent zones can be intuitively visualized, providing insight to the airtightness levels of building components. It is also observed that the airflow rates computed based on the airflow mappings can provide more guidance for the control of HVAC systems.
The Survival Effect of Metformin on Non-Small Cell Lung Cancer Treated with Chemotherapy: A Systematic Review
Authors: Li Qin , Fan Qiao , Wu Ji
Published: July 2023

Objective. Metformin is a common antidiabetic drug that has been reported to serve as an anticancer agent in combination with other therapies. But the effect of the addition of metformin on the survival of non-small cell lung cancer (NSCLC) patients undergoing chemotherapy is still controversial. We conducted this systematic review to evaluate the survival effect of metformin added to chemotherapy in NSCLC patients. Methods. Electronic literature search was performed in the PubMed, Embase, and Web of Science databases from their inception up to April 2023. The study region, study design, histological subtype of the NSCLC, tumor stage, treatment strategy, sample size, follow-up duration, diabetes status, and HR of OS or PFS of the included studies were extracted. The quality was assessed through Cochrane collaboration’s tool for RCT and the Newcastle–Ottawa scale (NOS) for observational studies, respectively. Results and conclusions. Eleven studies with a total of 4606 patients were finally included. Five RCTs showed a high risk of bias due to the open-label nature while six retrospective studies were of high quality. Two studies of NSCLC patients with diabetes reported significant benefits in overall survival from metformin addition, while one study of patients without diabetes reported a negative effect on the survival of metformin addition. The survival impact of metformin added to chemotherapy on unresectable NSCLC patients remains inconclusive. The survival benefit might be more prominent in patients with diabetes, awaiting further evidence.
Population Status and Threats to Galliform Bird in the Arjo-Didessa River Valley, Southwestern Ethiopia
Authors: Aynalem Yihenew , Bekele Afework , Afework Bogale Bezawork
Published: July 2023

The study was conducted to assess the species composition, population size, public knowledge, and threats to Galliform birds in the Arjo-Didessa River Valley, Southwestern Ethiopia. Data were collected from January 2018 to December 2020, covering both the dry and wet seasons. The study area was classified into four habitat categories: farmland, forest, grassland, and riverine areas. A line transects survey and point count routes were employed in the open habitats and dense habitats, respectively, to collect data. The species’ composition and relative abundance of Galliformes were estimated by timed species counting and encounter rates. To assess public knowledge and threats, direct inventories, questionnaire surveys, key informant interviews, and informal communications were employed. Three Galliform species, namely, Clapperton’s Francolin (Pternistis clappertoni), Helmeted Guineafowl (Numida meleagris), and Stone Partridge (Ptilopachus petrosus), were recorded in the area. The Helmeted Guineafowl were abundant (66.83%), Clapperton’s Francolin was common (30.14%), and Stone Partridge was a rare (3.03%) species. The population size of Galliformes recorded in the area was 461 during the dry season and 365 during the wet season, with a mean population size of 124.5 ± 11.5, 276 ± 33, and 12.5 ± 3.50 individuals of Clapperton’s Francolin, Helmeted Guineafowl, and Stone Partridge, respectively. The recorded flock size of Galliformes ranged from 1 to 22 individuals per flock. There was a statistically significant difference (F = 90.06, df = 3, and

p
<
0.05

) in the population size of Galliformes between habitats, where the highest mean was recorded in the farmland (141.5 ± 7.5) and the lowest in the riverine (61.5 ± 43.5) habitats. The majority of the respondents (86.36%, n = 286) have prior knowledge and awareness about guineafowl and francolin species. They use these species mainly as a source of food (55.06%), eggs and meat consumption, a source of income (28.48%), and other values (16.45%), including foster-rearing and medical practices. In addition, guarding, trapping, scarecrows, and related crop raid protection measures were employed in the area to protect crops from crop damage by these birds. Although there is factual public understanding and a positive attitude towards Galliformes in the study area, habitat destruction and loss, agricultural intensification, overgrazing, fire, fuelwood collection, agrochemicals, and hunting and egg collection were observed as major threats affecting the species and their habitats. Further research and community-based conservation interventions are, therefore, essential to thoroughly monitor the population trends of Galliformes and maintain their habitats in the region.
Supplementary Table S9 from Validation of Immunotherapy Response Score as predictive of pan-solid tumor anti-PD-1/PD-L1 benefit
Authors: Bulen Benjamin J , Khazanov Nickolay A , Hovelson Daniel H. , Lamb Laura E , Matrana Marc , Burkard Mark E , Yang Eddy Shih-Hsin , Edenfield William J. , Claire Dees Elizabeth , Onitilo Adedayo A. , Buchschacher Gary L , Miller Alan M , Parsons Benjamin M. , Wassenaar Timothy R. , Suga Jennifer M. , Siegel Robert D , Irvin William , Nair Suresh , Slim Jennifer N. , Misleh Jamal , Khatri Jamil , Masters Gregory A , Thomas Sachdev , Safa Malek M. , Anderson Daniel M. , Mowers Jonathan , Dusenbery Anna C , Drewery Stephanie , Plouffe Komal , Reeder Travis , Vakil Hana , Patrias Lynnae , Falzetta Amanda , Hamilton Ryan , Kwiatkowski Kat , Johnson D. Bryan , Rhodes Daniel R , Tomlins Scott A.
Published: July 2023

Supplementary Table S9 shows tumor mutation burden and Immunotherapy Response Score status by self -reported race in relevant tumor types from the Strata Clinical Molecular Database compared to Nasser et al.
Supplementary Table S8 from Validation of Immunotherapy Response Score as predictive of pan-solid tumor anti-PD-1/PD-L1 benefit
Authors: Bulen Benjamin J , Khazanov Nickolay A , Hovelson Daniel H. , Lamb Laura E , Matrana Marc , Burkard Mark E , Yang Eddy Shih-Hsin , Edenfield William J. , Claire Dees Elizabeth , Onitilo Adedayo A. , Buchschacher Gary L , Miller Alan M , Parsons Benjamin M. , Wassenaar Timothy R. , Suga Jennifer M. , Siegel Robert D , Irvin William , Nair Suresh , Slim Jennifer N. , Misleh Jamal , Khatri Jamil , Masters Gregory A , Thomas Sachdev , Safa Malek M. , Anderson Daniel M. , Mowers Jonathan , Dusenbery Anna C , Drewery Stephanie , Plouffe Komal , Reeder Travis , Vakil Hana , Patrias Lynnae , Falzetta Amanda , Hamilton Ryan , Kwiatkowski Kat , Johnson D. Bryan , Rhodes Daniel R , Tomlins Scott A.
Published: July 2023

Supplementary Table S8 shows tumor mutation burden and Immunotherapy Response Score status by self -reported race in the Strata Clinical Molecular Database
Supplementary Figure S5 from Targeting the Clear Cell Sarcoma Oncogenic Driver Fusion Gene EWSR1::ATF1 by HDAC Inhibition
Authors: Mae Hirokazu , Outani Hidetatsu , Imura Yoshinori , Chijimatsu Ryota , Inoue Akitomo , Kotani Yuki , Yasuda Naohiro , Nakai Sho , Nakai Takaaki , Takenaka Satoshi , Okada Seiji
Published: July 2023

Fig. S5 A combination of vorinostat and mivebresib is effective for CCS
Supplementary Table S7 from Validation of Immunotherapy Response Score as predictive of pan-solid tumor anti-PD-1/PD-L1 benefit
Authors: Bulen Benjamin J , Khazanov Nickolay A , Hovelson Daniel H. , Lamb Laura E , Matrana Marc , Burkard Mark E , Yang Eddy Shih-Hsin , Edenfield William J. , Claire Dees Elizabeth , Onitilo Adedayo A. , Buchschacher Gary L , Miller Alan M , Parsons Benjamin M. , Wassenaar Timothy R. , Suga Jennifer M. , Siegel Robert D , Irvin William , Nair Suresh , Slim Jennifer N. , Misleh Jamal , Khatri Jamil , Masters Gregory A , Thomas Sachdev , Safa Malek M. , Anderson Daniel M. , Mowers Jonathan , Dusenbery Anna C , Drewery Stephanie , Plouffe Komal , Reeder Travis , Vakil Hana , Patrias Lynnae , Falzetta Amanda , Hamilton Ryan , Kwiatkowski Kat , Johnson D. Bryan , Rhodes Daniel R , Tomlins Scott A.
Published: July 2023

Supplementary Table S7 shows a sub-group analysis of the PD-L1 IHC cohort
Supplementary Table S4 from Validation of Immunotherapy Response Score as predictive of pan-solid tumor anti-PD-1/PD-L1 benefit
Authors: Bulen Benjamin J , Khazanov Nickolay A , Hovelson Daniel H. , Lamb Laura E , Matrana Marc , Burkard Mark E , Yang Eddy Shih-Hsin , Edenfield William J. , Claire Dees Elizabeth , Onitilo Adedayo A. , Buchschacher Gary L , Miller Alan M , Parsons Benjamin M. , Wassenaar Timothy R. , Suga Jennifer M. , Siegel Robert D , Irvin William , Nair Suresh , Slim Jennifer N. , Misleh Jamal , Khatri Jamil , Masters Gregory A , Thomas Sachdev , Safa Malek M. , Anderson Daniel M. , Mowers Jonathan , Dusenbery Anna C , Drewery Stephanie , Plouffe Komal , Reeder Travis , Vakil Hana , Patrias Lynnae , Falzetta Amanda , Hamilton Ryan , Kwiatkowski Kat , Johnson D. Bryan , Rhodes Daniel R , Tomlins Scott A.
Published: July 2023

Supplementary Table S4 shows the characteristics of the patients used in the case cross-over analysis
Supplementary Table S3 from Validation of Immunotherapy Response Score as predictive of pan-solid tumor anti-PD-1/PD-L1 benefit
Authors: Bulen Benjamin J , Khazanov Nickolay A , Hovelson Daniel H. , Lamb Laura E , Matrana Marc , Burkard Mark E , Yang Eddy Shih-Hsin , Edenfield William J. , Claire Dees Elizabeth , Onitilo Adedayo A. , Buchschacher Gary L , Miller Alan M , Parsons Benjamin M. , Wassenaar Timothy R. , Suga Jennifer M. , Siegel Robert D , Irvin William , Nair Suresh , Slim Jennifer N. , Misleh Jamal , Khatri Jamil , Masters Gregory A , Thomas Sachdev , Safa Malek M. , Anderson Daniel M. , Mowers Jonathan , Dusenbery Anna C , Drewery Stephanie , Plouffe Komal , Reeder Travis , Vakil Hana , Patrias Lynnae , Falzetta Amanda , Hamilton Ryan , Kwiatkowski Kat , Johnson D. Bryan , Rhodes Daniel R , Tomlins Scott A.
Published: July 2023

Supplementary Table S3 shows unadjusted restricted mean survival time analysis of for real-world PFS and overall survival in the monotherapy validation cohort
Supplementary Table S12 from Validation of Immunotherapy Response Score as predictive of pan-solid tumor anti-PD-1/PD-L1 benefit
Authors: Bulen Benjamin J , Khazanov Nickolay A , Hovelson Daniel H. , Lamb Laura E , Matrana Marc , Burkard Mark E , Yang Eddy Shih-Hsin , Edenfield William J. , Claire Dees Elizabeth , Onitilo Adedayo A. , Buchschacher Gary L , Miller Alan M , Parsons Benjamin M. , Wassenaar Timothy R. , Suga Jennifer M. , Siegel Robert D , Irvin William , Nair Suresh , Slim Jennifer N. , Misleh Jamal , Khatri Jamil , Masters Gregory A , Thomas Sachdev , Safa Malek M. , Anderson Daniel M. , Mowers Jonathan , Dusenbery Anna C , Drewery Stephanie , Plouffe Komal , Reeder Travis , Vakil Hana , Patrias Lynnae , Falzetta Amanda , Hamilton Ryan , Kwiatkowski Kat , Johnson D. Bryan , Rhodes Daniel R , Tomlins Scott A.
Published: July 2023

Supplementary Table S12 shows a sub-group analysis of the chemotherapy, anti-PD-(L)1, and chemotherapy + anti-PD-(L)1 validation cohort
FIGURE 4 from Targeting the Clear Cell Sarcoma Oncogenic Driver Fusion Gene EWSR1::ATF1 by HDAC Inhibition
Authors: Mae Hirokazu , Outani Hidetatsu , Imura Yoshinori , Chijimatsu Ryota , Inoue Akitomo , Kotani Yuki , Yasuda Naohiro , Nakai Sho , Nakai Takaaki , Takenaka Satoshi , Okada Seiji
Published: July 2023

Depletion of BRD4 from the EWSR1 promoter region suppresses the transcription of EWSR1::ATF1.A, CCS cells were treated with 0–10 μmol/L vorinostat for 24 hours, and the protein expression of BRD4 was detected using Western blotting. B, Genome browser screenshot of the epigenome maps at EWSR1. Tracks visualize CUT&RUN-seq data for BRD4 (n = 2), and scATAC-seq data are shown for treatment with 3 μmol/L vorinostat or vehicle for 24 hours. Blue highlight shows the EWSR1 promoter region. C, CCS cells were treated with 0–3 μmol/L JQ1 for 48 hours, and the number of viable cells was estimated using a WST-8 assay (n = 3). The calculated IC50 values are shown in Table 1. D, CCS cells were treated with 0, 0.3, 1.0, 3.0, or 10.0 μmol/L JQ1 for 24 hours. EWSR1::ATF1 protein expression levels were estimated via Western blotting. E, CCS cells were treated with 0, 0.3, and 3.0 μmol/L JQ1 for 24 hours. EWSR1::ATF1 mRNA levels in CCS cells were quantified using qRT-PCR (normalized to GAPDH; n = 3). Data in C and E are means ± SDs. *, P < 0.05; **, P < 0.01 (Student t test).
FIGURE 3 from Targeting the Clear Cell Sarcoma Oncogenic Driver Fusion Gene EWSR1::ATF1 by HDAC Inhibition
Authors: Mae Hirokazu , Outani Hidetatsu , Imura Yoshinori , Chijimatsu Ryota , Inoue Akitomo , Kotani Yuki , Yasuda Naohiro , Nakai Sho , Nakai Takaaki , Takenaka Satoshi , Okada Seiji
Published: July 2023

Vorinostat alters EWSR1 promoter activity and histone modification at the promoter region. A, CCS cells were treated with 0, 0.3, 3.0, or 30.0 μmol/L vorinostat for 6 hours. Relative EWSR1 promoter activity was measured via a reporter assay (n = 3). B, MP-CCS-SY and SU-CCS1 cells were treated with 0–10 μmol/L vorinostat for 24 hours, and the protein expression levels of the active acetyl-histone markers H3K27ac and H3K9ac were detected using Western blotting. C, Genome browser screenshot of the epigenome maps at EWSR1. Tracks visualize CUT&RUN-seq data for two acetyl-histone markers (H3K27ac and K3K9ac) (n = 2), and scATAC-seq data are shown for treatments with 3 μmol/L vorinostat or vehicle for 24 hours. Blue highlights indicate the inserted DNA regions used in the reporter assay. Four CCS cells were treated with 3 μmol/L vorinostat or vehicle for 24 hours, and the levels of H3K27ac (D), H3K9ac (E), and H3K4 me3 (F) at three sites within the EWSR1 promoter region were analyzed using CUT&RUN-qPCR (n = 3). The values shown are relative to the input. Data in A and D–F are means ± SDs. *, P < 0.05; **, P < 0.01 (Student t test).
Supplementary Table S1 from Validation of Immunotherapy Response Score as predictive of pan-solid tumor anti-PD-1/PD-L1 benefit
Authors: Bulen Benjamin J , Khazanov Nickolay A , Hovelson Daniel H. , Lamb Laura E , Matrana Marc , Burkard Mark E , Yang Eddy Shih-Hsin , Edenfield William J. , Claire Dees Elizabeth , Onitilo Adedayo A. , Buchschacher Gary L , Miller Alan M , Parsons Benjamin M. , Wassenaar Timothy R. , Suga Jennifer M. , Siegel Robert D , Irvin William , Nair Suresh , Slim Jennifer N. , Misleh Jamal , Khatri Jamil , Masters Gregory A , Thomas Sachdev , Safa Malek M. , Anderson Daniel M. , Mowers Jonathan , Dusenbery Anna C , Drewery Stephanie , Plouffe Komal , Reeder Travis , Vakil Hana , Patrias Lynnae , Falzetta Amanda , Hamilton Ryan , Kwiatkowski Kat , Johnson D. Bryan , Rhodes Daniel R , Tomlins Scott A.
Published: July 2023

Supplementary Table S1 shows the characteristics of the anti-PD-(L)1 monotherapy cohort
Supplementary Figure S8 from Validation of Immunotherapy Response Score as predictive of pan-solid tumor anti-PD-1/PD-L1 benefit
Authors: Bulen Benjamin J , Khazanov Nickolay A , Hovelson Daniel H. , Lamb Laura E , Matrana Marc , Burkard Mark E , Yang Eddy Shih-Hsin , Edenfield William J. , Claire Dees Elizabeth , Onitilo Adedayo A. , Buchschacher Gary L , Miller Alan M , Parsons Benjamin M. , Wassenaar Timothy R. , Suga Jennifer M. , Siegel Robert D , Irvin William , Nair Suresh , Slim Jennifer N. , Misleh Jamal , Khatri Jamil , Masters Gregory A , Thomas Sachdev , Safa Malek M. , Anderson Daniel M. , Mowers Jonathan , Dusenbery Anna C , Drewery Stephanie , Plouffe Komal , Reeder Travis , Vakil Hana , Patrias Lynnae , Falzetta Amanda , Hamilton Ryan , Kwiatkowski Kat , Johnson D. Bryan , Rhodes Daniel R , Tomlins Scott A.
Published: July 2023

Supplementary Figure S8. shows overlap weighting propensity score analysis of the chemotherapy, anti-PD-(L)1, and chemotherapy + anti-PD-(L)1 validation cohort
Supplementary Figure S7 from Validation of Immunotherapy Response Score as predictive of pan-solid tumor anti-PD-1/PD-L1 benefit
Authors: Bulen Benjamin J , Khazanov Nickolay A , Hovelson Daniel H. , Lamb Laura E , Matrana Marc , Burkard Mark E , Yang Eddy Shih-Hsin , Edenfield William J. , Claire Dees Elizabeth , Onitilo Adedayo A. , Buchschacher Gary L , Miller Alan M , Parsons Benjamin M. , Wassenaar Timothy R. , Suga Jennifer M. , Siegel Robert D , Irvin William , Nair Suresh , Slim Jennifer N. , Misleh Jamal , Khatri Jamil , Masters Gregory A , Thomas Sachdev , Safa Malek M. , Anderson Daniel M. , Mowers Jonathan , Dusenbery Anna C , Drewery Stephanie , Plouffe Komal , Reeder Travis , Vakil Hana , Patrias Lynnae , Falzetta Amanda , Hamilton Ryan , Kwiatkowski Kat , Johnson D. Bryan , Rhodes Daniel R , Tomlins Scott A.
Published: July 2023

Supplementary Figure S7. shows covariate adjusted Kaplan-Meier analysis of the chemotherapy, anti-PD-(L)1, and chemotherapy + anti-PD-(L)1 validation cohort
Supplementary Figure S5 from Validation of Immunotherapy Response Score as predictive of pan-solid tumor anti-PD-1/PD-L1 benefit
Authors: Bulen Benjamin J , Khazanov Nickolay A , Hovelson Daniel H. , Lamb Laura E , Matrana Marc , Burkard Mark E , Yang Eddy Shih-Hsin , Edenfield William J. , Claire Dees Elizabeth , Onitilo Adedayo A. , Buchschacher Gary L , Miller Alan M , Parsons Benjamin M. , Wassenaar Timothy R. , Suga Jennifer M. , Siegel Robert D , Irvin William , Nair Suresh , Slim Jennifer N. , Misleh Jamal , Khatri Jamil , Masters Gregory A , Thomas Sachdev , Safa Malek M. , Anderson Daniel M. , Mowers Jonathan , Dusenbery Anna C , Drewery Stephanie , Plouffe Komal , Reeder Travis , Vakil Hana , Patrias Lynnae , Falzetta Amanda , Hamilton Ryan , Kwiatkowski Kat , Johnson D. Bryan , Rhodes Daniel R , Tomlins Scott A.
Published: July 2023

Supplementary Figure S5 shows robustness of Immunotherapy Response Score to self-reported race
Supplementary Figure S3 from Validation of Immunotherapy Response Score as predictive of pan-solid tumor anti-PD-1/PD-L1 benefit
Authors: Bulen Benjamin J , Khazanov Nickolay A , Hovelson Daniel H. , Lamb Laura E , Matrana Marc , Burkard Mark E , Yang Eddy Shih-Hsin , Edenfield William J. , Claire Dees Elizabeth , Onitilo Adedayo A. , Buchschacher Gary L , Miller Alan M , Parsons Benjamin M. , Wassenaar Timothy R. , Suga Jennifer M. , Siegel Robert D , Irvin William , Nair Suresh , Slim Jennifer N. , Misleh Jamal , Khatri Jamil , Masters Gregory A , Thomas Sachdev , Safa Malek M. , Anderson Daniel M. , Mowers Jonathan , Dusenbery Anna C , Drewery Stephanie , Plouffe Komal , Reeder Travis , Vakil Hana , Patrias Lynnae , Falzetta Amanda , Hamilton Ryan , Kwiatkowski Kat , Johnson D. Bryan , Rhodes Daniel R , Tomlins Scott A.
Published: July 2023

Supplementary Figure S3 shows how Immunotherapy Response Score adds to tumor mutation burden and microsatellite instability status for anti-PD-(L)1 monotherapy clinical benefit
Supplementary Figure S2 from Validation of Immunotherapy Response Score as predictive of pan-solid tumor anti-PD-1/PD-L1 benefit
Authors: Bulen Benjamin J , Khazanov Nickolay A , Hovelson Daniel H. , Lamb Laura E , Matrana Marc , Burkard Mark E , Yang Eddy Shih-Hsin , Edenfield William J. , Claire Dees Elizabeth , Onitilo Adedayo A. , Buchschacher Gary L , Miller Alan M , Parsons Benjamin M. , Wassenaar Timothy R. , Suga Jennifer M. , Siegel Robert D , Irvin William , Nair Suresh , Slim Jennifer N. , Misleh Jamal , Khatri Jamil , Masters Gregory A , Thomas Sachdev , Safa Malek M. , Anderson Daniel M. , Mowers Jonathan , Dusenbery Anna C , Drewery Stephanie , Plouffe Komal , Reeder Travis , Vakil Hana , Patrias Lynnae , Falzetta Amanda , Hamilton Ryan , Kwiatkowski Kat , Johnson D. Bryan , Rhodes Daniel R , Tomlins Scott A.
Published: July 2023

Supplementary Figure S2 shows a diagram of the overall study
Water level control of small-scale recirculating aquaculture system with protein skimmer using fuzzy logic controller
Authors: Mulyanto Mulyanto , Suprapty Bedi , Gaffar Achmad Fanany Onnilita , Sumadi Muhammad Taufiq
Published: July 2023

The recirculating aquaculture system (RAS) is a land-based aquaculture facility, either open-air or indoors, that minimizes water consumption by filtering, adapting, and reusing water. Solid organic matter from fish waste and food waste directly becomes waste that needs to be eliminated because it is a source of increasing total ammonia nitrogen (TAN), total suspended solids (TSS), total dissolved solids (TDS), and also has an impact on reducing dissolved oxygen (DO). RAS requires a water level control system so the fish tank does not experience water shortages or floods, disrupting the aquatic aquaculture ecosystem. In this study, small-scale RAS is modeled using a 3-coupled tanks system approach with a tank configuration that follows the most straightforward RAS water recirculation process (fish tank, mechanic filter, biofilter). Clean water from the reservoir flows into the fish tank through a protein skimmer. This study applies the fuzzy logic controller (FLC) to control the water level in the protein skimmer and biofilter tanks by controlling the position of several valves where the placement positions of the valves have been determined according to system requirements. The study results show that the tuned single-input FLC has the best average output response characteristics with ts=50, h1ss=49.98, ess=0.02 in protein skimmer and ts=4700, h1ss=39.75, ess=0.25 in the tank system.
A review of the jumping plant-lice (Hemiptera: Psylloidea) of the Canary Islands, with descriptions of two new genera and sixteen new species
Authors: BASTIN SASKIA , BURCKHARDT DANIEL , REYES-BETANCORT J. ALFREDO , HERNÁNDEZ-SUÁREZ ESTRELLA , OUVRARD DAVID
Published: July 2023

The psyllid fauna of the Canary Islands is reviewed on the basis of recent field work on Tenerife, La Gomera, La Palma Gran Canaria and Lanzarote, as well as the examination of material deposited in several collections. Two new genera and 16 new species are described: Drepanoza Bastin, Burckhardt & Ouvrard gen. nov., Percyella Bastin, Burckhardt & Ouvrard gen. nov., Agonoscena atlantica Bastin, Burckhardt & Ouvrard sp. nov., A. sinuata Bastin, Burckhardt & Ouvrard sp. nov., Arytaina meridionalis Bastin, Burckhardt & Ouvrard sp. nov., Cacopsylla crenulatae Bastin, Burckhardt & Ouvrard sp. nov., C. falcicauda Bastin, Burckhardt & Ouvrard sp. nov., Diaphorina gonzalezi Bastin, Burckhardt & Ouvrard sp. nov., Drepanoza canariensis Bastin, Burckhardt & Ouvrard sp. nov., D. fruticulosi Bastin, Burckhardt & Ouvrard sp. nov., D. molinai Bastin, Burckhardt & Ouvrard sp. nov., Euphyllura confusa Bastin, Burckhardt & Ouvrard sp. nov., Percyella benahorita Bastin, Burckhardt & Ouvrard sp. nov., P. canari Bastin, Burckhardt & Ouvrard sp. nov., P. gomerita Bastin, Burckhardt & Ouvrard sp. nov., P. guanche Bastin, Burckhardt & Ouvrard sp. nov., Strophingia canariensis Bastin, Burckhardt & Ouvrard sp. nov. and S. paligera Bastin, Burckhardt & Ouvrard sp. nov. Arytaina insularis Loginova, 1976, stat. nov. is elevated from a subspecies of A. devia Loginova, 1976 to species rank. Five new combinations are proposed: Drepanoza fernandesi (Aguiar, 2001) comb. nov., D. lienhardi (Burckhardt, 1981) comb. nov., D. montanetana (Aguiar, 2001) comb. nov., D. pittospori (Aguiar, 2001) comb. nov. and Lauritrioza laurisilvae (Hodkinson, 1990) comb. nov., all transferred from Trioza. The hitherto unknown last-instar immatures are described for Megadicrania tecticeps Loginova, 1976, Cacopsylla atlantica (Loginova, 1976) and Lauritrioza laurisilvae (Hodkinson, 1990). We also report Agonoscena targionii (Lichtenstein, 1874) for the first time from the Canary Islands. Our review increases the number of known psyllid taxa from the Canary Islands to 24 genera and 62 species (one of which remains undescribed). Endemism, host plant relationships and biogeographic patterns are discussed. Keys for the identification of adults and immatures are provided, as well as information on host plants, distribution and predators.
Pacific–North American Teleconnection Tumbles Snowfall Records West of the Cascades during Christmas Week 2021
Authors: Guan Bin , Nigam Sumant
Published: July 2023

During the week of Christmas 2021, winter storms pummeled the Pacific Northwest and broke daily temperature and snowfall records in scores, especially west of the Cascades and notably in Oregon. With La Niña ruling the tropical Pacific, the record-setting, disruptive snowfall during Christmas week raised questions about its origin, especially as the seasonal outlook was for below-normal precipitation. We show that Pacific–North American (PNA) teleconnection—a well-documented subseasonal variability pattern during winter—reigned over the region in its negative phase; it was the strongest 7-day PNA episode in December in more than 50 years. It led to robust northwesterly onshore flow, whose interaction with the Coastal, Cascade, and Sierra ranges led to blockbuster snowfall and precipitation. Note that one seldom encounters circulation anomalies consisting of just one winter teleconnection pattern. Also worth noting is the tremendous power of subseasonal variability in recharging Western water resources in the context of the seasonal gloom from a La Niña–intensified West Coast drought.
Technification and Securitisation: The Mechanism of ‘Rendering Technical’ in Polish Nuclear Energy Politics
Authors: Berling Trine Villumsen , Surwillo Izabela
Published: July 2023

Technology is changing how we live our lives – of this there is no doubt. But how technology affects political deliberation, through which pathways, and how such processes compare to other forms of social mechanisms at play are less clear. Critical security studies have yet to reflect much on this. While the Copenhagen School outlined the workings of the securitisation mechanism and inspired further research into its dynamic together with analytical enquiries into other grammars, logics and security mechanisms operating in different sectors, the role of ‘the technical’ in the broader political processes remains under-researched. The article conceptualises the social mechanism of technification, outlines three possible forms to be found in practice and illustrates them using the example of the development of the nuclear energy program in Poland.

Technification et sécurisation : « Techniciser » les politiques énergétiques nucléaires en Pologne
Use of Reclaimed Asphalt Pavement Aggregates in Pervious Concrete: A Pilot Field Study
Authors: Sahdeo Surya Kant , Ransinchung R.N. G.D. , Thakur Sanjay Singh
Published: July 2023

Pervious concrete (PC) is emerging as a novel pavement material for its unique characteristics of reducing storm-water runoff and mitigating urban heat islands. This makes it well suited for low-volume pavement applications. It is also expected that reclaimed asphalt pavement (RAP) aggregates as a replacement for natural aggregates will improve the porosity and permeability of PC pavement mixtures. As a result, this study checks the feasibility of using RAP-based PC mixes in a parking space. The construction process will offer a guide to the field engineer on how to push this technology further when recycled materials are used. The PC parking space, with a capacity of 5 tonnes laden weight, was developed by replacing natural aggregate with 25% RAP aggregate (30% of 10 mm and 70% of 4.75 mm). Field mixtures were found to have higher porosity and lower density when compared with laboratory-prepared mixes. The field infiltration capacity was observed to be in the range of 0.50–1.75 cm/s while maintaining a flexural capacity of 2.36 MPa to 3.17 MPa (342.28 pounds per square inch (psi) to 460 psi). This suggests that using binary-graded RAP aggregates helps create an interconnected pore network, enhancing PC mixtures’ transport capabilities. The present study illustrates the step-by-step construction process of PC pavements for field applications. Based on the findings, it is recommended that 50% could be the maximum feasible limit for the usage of RAP aggregates in PC field mixes.
A Longitudinal Analysis of Residential Mobility and Experience of Client Violence Among Women Who Exchange Sex in Baltimore
Authors: Hendrickson Zoé Mistrale , Tomko Catherine , Galai Noya , Sisson Laura Nicole , Glick Jennifer L. , Sherman Susan G.
Published: July 2023

Residential mobility remains an underexplored yet critical construct that may influence the risk of violence among women who exchange sex. This study examined the longitudinal relationship between residential mobility and experience of client-perpetrated physical or sexual violence among women who exchange sex in Baltimore, Maryland. Participants were at least at 18 years of age, were cisgender women, reported having engaged in transactional sex three or more times within the last 3 months, and were willing to be contacted for 6-, 12-, and 18-month follow-up visits. Analyses of responses from 370 women who exchange sex participating in at least one study visit were conducted. Unadjusted and adjusted Poisson regression models of the association over time between residential mobility and recent experience of physical or sexual violence were fit. Generalized estimating equations with an exchangeable correlation structure and robust variance estimation were used to account for clustering of participants’ responses over time. Findings demonstrated that those who had lived in at least four places in the past 6 months had a 39% increased risk of client-perpetrated physical violence (aRR: 1.39; 95% CI: 1.07–1.80; p < .05) and a 63% increased risk of sexual violence (aRR: 1.63; 95% CI: 1.14–2.32; p < .01) compared to their less-mobile counterparts. These findings provide necessary evidence of correlations over time between residential mobility and experience of client-perpetrated violence among women who exchange sex. Strengthening our understanding of how residential mobility intersects with violence is critical for the development of public health interventions that are relevant to women’s lives and needs. Future interventions should explore including residential mobility, a critical pillar of housing instability, with efforts to address client-perpetrated violence.
Cognitive Reserve Potential: Capturing Cognitive Resilience Capability in Adolescence
Authors: Conte Federica , Rinaldi Luca , Gerosa Tiziano , Mondini Sara , Costantini Giulio , Girelli Luisa
Published: July 2023

Cognitive reserve (CR) represents the adaptive response of the cognitive system responsible for preserving normal functioning in the face of brain damage. Experiential factors such as education, occupation, and leisure activities influence the development of CR. Theoretically, such factors build up from childhood and across adulthood. Thus, appropriate tools to define and measure CR as early as adolescence are essential to understand its developmental processes. To this aim, we introduce the construct of “Cognitive Reserve Potential” (CRP) and its corresponding index of experiential factors tailored to youth. We investigated prototypical youth exposures potentially associated with the lifelong development of CR (e.g., sport practice, musical experiences, cultural activities, and relationships with peers and family). Principal component analysis and confirmatory factor analysis identified and replicated the CRP factor structure on two independent samples of Italian students: N = 585 (295 F) and N = 351 (201 F), ages 11 to 20. CRP was associated mainly with family socio-cultural status (i.e., socioeconomic status [SES], Home Possessions, and Books at Home). Results confirmed the strength of the factorial model and warranted the proposal of the CRP-questionnaire as an innovative tool for understanding CR evolutionary dynamics.
Adaptive backstepping dynamic sliding mode control for maglev turning motor spindle based on limited time preset performance
Authors: Liu Houcai , Cao Zheng , Kang Huimin , Ouyang Zhihai , Duan Lianghui
Published: July 2023

In the process of turning a maglev motorized spindle, there are problems such as system model time-varying, cross-coupling of control parameters, difficult measurement of system state variables, and nonlinear characteristics of active magnetic bearings, which lead to the inevitable cutting chatter phenomenon, difficult control algorithm design, and then the reduction of workpiece surface quality and accuracy, affecting machining efficiency and tool life. In this paper, the “multimodal-distributed parameter” model is extended to the “magnetic bearing-rotor-workpiece” variable mass turning process. An adaptive backstepping fast dynamic terminal sliding mode control is designed to address the model’s time-varying parameters and cross-coupling issues. In view of the difficulty in measuring the vibration displacement at the cutting point, the displacement field reconstruction method was introduced to reconstruct the vibration displacement field online and provide effective feedback for the previously designed control strategy. Finally, the proposed controller is applied to adjust and control the turning process of a maglev motorized spindle and compared with other advanced controllers. The simulation results show that the proposed control method has a better control effect than other control methods in the presence of unmodeled dynamics, uncertainties, and external disturbances.
Monitoring prisoners preparing for release: Who ‘fails’ in open prison conditions?
Authors: Goodley Gary , Pearson Dominic
Published: July 2023

Open prisons play a vital role in offender rehabilitation and resettlement but absconds, temporary release failures (TRFs) and re-offences have damaging implications for the legitimacy of these institutions. Identifying and mitigating the risk for such ‘failures’ is crucial. The present study examined predictors of failure in a sample of 316 adult male prisoners in two open prisons in England and Wales. Almost one-third ( n = 100) of the sample failed in open conditions, the greatest proportion ( n = 83 , 26.3%) instigated by the prison to maintain security and good order (security recall). Yet, only seven re-offended in the year following custodial release . Absconds, custodial re-offences, and TRFs were rare events. Regression analysis identified five factors predicting security recall. Current behaviour, rather than static/historical risk factors, more reliably predicted such failures. Behavioural monitoring and systemic policy re-evaluation are proposed as way of mitigating failures in open prisons.
Mpro-targeted anti-SARS-CoV-2 inhibitor-based drugs
Authors: She Zhuxin , Yao Yinuo , Wang Conglong , Li Yi , Xiong Xiaohui , Liu Yuanyuan
Published: July 2023

The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 is a global health emergency. The main protease is an important drug target in coronaviruses. It plays an important role in the processing of viral RNA-translated polyproteins and is highly conserved in the amino acid sequence and three-dimensional structure, making it a good drug target for which several small molecule inhibitors are available. This paper describes the various anti-severe acute respiratory syndrome coronavirus 2 inhibitor drugs targeting Mpro discovered since the severe acute respiratory syndrome coronavirus 2 outbreak at the end of 2019, with all these compounds inhibiting severe acute respiratory syndrome coronavirus 2 Mpro activity in vitro. This provides a reference for the development of severe acute respiratory syndrome coronavirus 2 Mpro-targeted inhibitors and the design of therapeutic approaches to address newly emerged severe acute respiratory syndrome coronavirus 2 mutant strains with immune evasion capabilities.