bluuebunny/crossref_metadata_2025 huggingface dataset:
Lifestyle Practices and Mental Health in Adolescents: Explorative Analysis from Malaysian Health and Morbidity Survey 2017
Authors: Mushaddik Irma Liyana , Khalid Karniza , Anuar Amalina , Che Hat Siti Zulaiha , Jamaluddin Ruzita
Published: October 2022

Many significant psychosocial problems may go undetected and untreated in adolescents. We aim to determine the prevalence of high-risk behaviors among Malaysian adolescents. Retrospective data analysis was performed using data from the National Health and Morbidity Survey (NHMS) 2017 report. The dataset included 27,497 responses from adolescents aged 13 to 17 years old from five established topographic zones: northern peninsular, east coast peninsular, southern peninsular, central, and east Malaysia. The strength of associations between selected high-risk behaviors and different topographical zones were performed using logistic regression analysis. Adolescents from the northern peninsular reported the highest prevalence of suicidal attempt (27.1%) and active drug user (30.1%). The same region reported the highest prevalence of those who ever had sexual intercourse (SI) (27.2%), with 32.5% who had their first SI before 14 years old, while east Malaysia reported the highest prevalence of current smokers (26.1%) and current alcohol consumers (30.6%). Overall poor lifestyle choices were evident in the northern peninsular region. Hence, specific districts breakdown may enable targeted interventional lifestyle strategies for adolescents at risk.
Titanium Oxide and Zinc Oxide Nanoparticles in Combination with Cadmium Tolerant Bacillus pumilus Ameliorates the Cadmium Toxicity in Maize
Authors: Shafiq Tayyab , Yasmin Humaira , Shah Zafar Abbas , Nosheen Asia , Ahmad Parvaiz , Kaushik Prashant , Ahmad Ajaz
Published: October 2022

The efficiency of Cd-tolerant plant growth-promoting bacteria (PGPB), zinc oxide nanoparticles (ZnO NPs), and titanium dioxide nanoparticles (TiO2) in maize growing in Cd-rich conditions was tested in the current study. The best Cd-tolerant strain, Bacillus pumilus, exhibited plant growth stimulation in vivo and in vitro experiments. We determined the toxic concentrations (30 (ppm)) of both NPs for plant growth. B. pumilus, ZnO NPs (20 (ppm)), and TiO2 NPs (10 (ppm)) had a synergistic effect on plant growth promotion in Cd-contaminated soil (120 (ppm)) in a pot experiment. Both alone and in combination, these therapies reduced Cd toxicity, resulting in improved stress metabolism and defense responses. The combined treatments showed increased relative water content, photosynthetic pigments, proline, total sugars, and proteins and significantly reduced lipid peroxidation. Moreover, this combination increased the levels of minerals and antioxidants and reduced Cd bioaccumulation in shoots and roots by 40–60%. Our in silico pipeline presented a novel picture of the participation of ZnO–TiO2 protein interaction in both B. pumilus and maize. These findings provide fresh insights on the use of B. pumilus, ZnO, and TiO2 NPs, both separately and in combination, as a viable and environmentally benign strategy for reducing Cd stress in maize.
Wideband Circularly Polarized Filtering Hybrid Antenna
Authors: Qian Yahui , Xie Shumin
Published: October 2022

In this paper, a wideband circularly polarized (CP) filtering hybrid antenna is presented. The liquid dielectric resonator (DR) is excited by a microstrip-coupled cross-slot to generate CP radiation. Four inverted L-shaped strips are loaded on the ground plane to introduce an additional CP resonant point, then two adjacent axial ratio (AR) minima are combined to improve the bandwidth of the single-feed CP antenna. By etching a U-shaped slot and loading a C-shaped microstrip stub on the microstrip line, two tunable radiation nulls near the edges of the working band can be obtained without any extra filtering circuits. To verify the design, a filtering CP antenna is designed, fabricated, and tested. Measured results show that the antenna provides wider 3-dB AR and an impedance bandwidth of 38.8% from 1.36 to 2.02 GHz and 39.4% from 1.37 to 2.04 GHz, respectively. The realized gain of the proposed antenna is stable at about 7.8 dBi within the whole working band. A reasonable agreement between measured and simulated results is observed.
New Perspectives on Excavation Disturbance Zones: Main Driving Forces
Authors: Kong Xiangyong , Wang Shanyong , Song Zongwu , Tang Chun’an , Yu Chaoyun , Chen Xu
Published: October 2022

The support theory of the excavation disturbance zone (EDZ) cannot provide an accurate physical explanation or theoretical description of the time-dependent properties required for the development of an EDZ. Therefore, the primary factors that cause the formation of an EDZ should be determined to further improve the support theory of the EDZ and grasp the principle underlying the control of the long-term stability of rock masses. Considering the headrace tunnel and nuclear waste repository as the research background, this study aimed to understand the deformation damage evolution process of the surrounding rock after tunnel excavation under different working conditions using the self-developed realistic failure process analysis (RFPA2D) code. The simulation revealed the following. First, an EDZ is formed, although the deformation damage to the surrounding rock is relatively small under the action of environmental factors. Second, under the action of stress in the abovementioned case, the deformation speed, damage degree, and scope of the surrounding rock significantly increase, accelerating the formation and development of the EDZ. Therefore, the boundary of the EDZ expands significantly. Third, when environmental factors are blocked, the range of the EDZ is small due to the small deformation damage to the surrounding rock. Thus, the main factors responsible for the formation of the EDZ are environmental factors, whereas stress is only an auxiliary factor. A numerical simulation method that considers environmental factors can more accurately reproduce the formation of an EDZ. Therefore, a study of the internal mechanism of the EDZ phenomenon can provide a more in-depth understanding of the essential characteristics of an EDZ at the macro level. Furthermore, it can provide a scientific basis and method for the construction and support designs of underground excavation projects and widen the possibilities for further improving the support theory of the EDZ.
Parkin Inhibits RANKL-Induced Osteoclastogenesis and Ovariectomy-Induced Bone Loss
Authors: Hou Weiduo , Chen Mo , Ye Chenyi , Chen Erman , Li Weixu , Zhang Wei
Published: October 2022

Osteoporosis and osteoporotic fractures comprise a substantial health and socioeconomic burden. The leading cause of osteoporosis is an imbalance in bone formation and bone resorption caused by hyperactive osteoclasts. Therefore, a new strategy to suppress osteoclastogenesis is needed. Parkin is likely closely associated with bone metabolism, although its role in osteoclastogenesis is unclear. In this study, the Parkin protein inhibited the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast formation, osteoclast-specific gene expression, F-actin ring formation, and bone resorption pit formation in vitro. Moreover, depletion of Parkin enhanced RANKL-induced osteoclast formation, osteoclast-specific gene expression, F-actin ring formation, and bone resorption pit formation. Reactive oxygen species (ROS) activity was suppressed, while autophagy was upregulated with the presence of the Parkin protein. ROS activity was upregulated and autophagy was decreased due to Parkin knockdown. In addition, intravenous administration of Parkin rescued ovariectomy-induced bone loss and reduced osteoclastogenesis in vivo. Collectively, Parkin has therapeutic potential for diseases associated with overactive osteoclasts.
Oxytocin: A Multi-Functional Biomolecule with Potential Actions in Dysfunctional Conditions; From Animal Studies and Beyond
Authors: Tsingotjidou Anastasia S.
Published: October 2022

Oxytocin is a hormone secreted from definite neuroendocrine neurons located in specific nuclei in the hypothalamus (mainly from paraventricular and supraoptic nuclei), and its main known function is the contraction of uterine and/or mammary gland cells responsible for parturition and breastfeeding. Among the actions of the peripherally secreted oxytocin is the prevention of different degenerative disorders. These actions have been proven in cell culture and in animal models or have been tested in humans based on hypotheses from previous studies. This review presents the knowledge gained from the previous studies, displays the results from oxytocin intervention and/or treatment and proposes that the well described actions of oxytocin might be connected to other numerous, diverse actions of the biomolecule.
Arctigenin Attenuates Vascular Inflammation Induced by High Salt through TMEM16A/ESM1/VCAM-1 Pathway
Authors: Zeng Mengying , Xie Ziyan , Zhang Jiahao , Li Shicheng , Wu Yanxiang , Yan Xiaowei
Published: October 2022

Salt-sensitive hypertension is closely related to inflammation, but the mechanism is barely known. Transmembrane member 16A (TMEM16A) is the Ca2+-activated chloride channel in epithelial cells, smooth muscle cells, and sensory neurons. It can promote inflammatory responses by increasing proinflammatory cytokine release. Here, we identified a positive role of TMEM16A in vascular inflammation. The expression of TMEM16A was increased in high-salt-stimulated vascular smooth muscle cells (VSMCs), whereas inhibiting TMEM16A or silencing TMEM16A with small interfering RNA (siRNA) can abolish this effect in vitro or in vivo. Transcriptome analysis of VSMCs revealed some differential downstream genes of TMEM16A related to inflammation, such as endothelial cell-specific molecule 1 (ESM1) and CXC chemokine ligand 16 (CXCL16). Overexpression of TMEM16A in VSMCs was accompanied by high levels of ESM1, CXCL16, intercellular adhesion molecule-1 (ICAM-1), and vascular adhesion molecule-1 (VCAM-1). We treated VSMCs cultured with high salt and arctigenin (ARC), T16Ainh-A01 (T16), and TMEM16A siRNA (siTMEM16A), leading to greatly decreased ESM1, CXCL16, VCAM-1, and ICAM-1. Beyond that, silencing ESM1, the expression of VCAM-1 and ICAM-1, and CXCL16 was attenuated. In conclusion, our results outlined a signaling scheme that increased TMEM16 protein upregulated ESM1, which possibly activated the CXCL16 pathway and increased VCAM-1 and ICAM-1 expression, which drives VSMC inflammation. Beyond that, arctigenin, as a natural inhibitor of TMEM16A, can reduce the systolic blood pressure (SBP) of salt-sensitive hypertension mice and alleviate vascular inflammation.
Alprazolam Detection Using an Electrochemical Nanobiosensor Based on AuNUs/Fe-Ni@rGO Nanocomposite
Authors: Sadrabadi Emadoddin Amin , Khosravi Fatemeh , Benvidi Ali , Shiralizadeh Dezfuli Amin , Khashayar Pouria , Khashayar Patricia , Azimzadeh Mostafa
Published: October 2022

Despite all the psychological advantages of alprazolam, its long list of toxic properties and interactions has caused concern and highlighted the need for a reliable sensing method. In this study, we developed a simple, highly sensitive electrochemical nanobiosensor to determine the desirable dose of alprazolam, averting the undesirable consequences of overdose. Gold nanourchins (AuNUs) and iron-nickel reduced graphene oxide (Fe-Ni@rGO) were immobilized on a glassy carbon electrode, which was treated beforehand. The electrode surface was characterized using cyclic voltammetry, Fourier transform infrared spectroscopy, scanning electron microscopy/energy-dispersive X-ray spectroscopy, and differential pulse voltammetry. The fabricated sensor showed two linear ranges (4 to 500 µg L−1 and 1 to 50 mg L−1), low limit of detection (1 µg L−1), high sensitivity, good repeatability, and good recovery. Increased –OH and carboxyl (-COOH) groups on the electrode surface, resulting in improved the adsorption of alprazolam and thus lower limit of detection. This nanobiosensor could detect alprazolam powder dissolved in diluted blood serum; we also studied other benzodiazepine drugs (clonazepam, oxazepam, and diazepam) with this nanobiosensor, and results were sensible, with a significant difference.
Device Exposure and Patient Risk Factors’ Impact on the Healthcare-Associated Infection Rates in PICUs
Authors: Fresán-Ruiz Elena , Pons-Tomás Gemma , de Carlos-Vicente Juan Carlos , Bustinza-Arriortua Amaya , Slocker-Barrio María , Belda-Hofheinz Sylvia , Nieto-Moro Montserrat , Uriona-Tuma Sonia María , Pinós-Tella Laia , Morteruel-Arizcuren Elvira , Schuffelmann Cristina , Peña-López Yolanda , Bobillo-Pérez Sara , Jordan Iolanda ,   on behalf of the Pediatric-ENVIN-HELICS Study Group
Published: October 2022

Healthcare-associated infections related to device use (DA-HAIs) are a serious public health problem since they increase mortality, length of hospital stay and healthcare costs. We performed a multicenter, prospective study analyzing critically ill pediatric patients admitted to 26 Spanish pediatric intensive care units (PICUs) over a 3-month period each year from 2014 to 2019. To make comparisons and evaluate the influence of HAI Zero Bundles (care bundles that intend to reduce the DA-HAI rates to zero) on PICU HAI rates, the analysis was divided into two periods: 2014–2016 and 2017–2019 (once most of the units had incorporated all the Zero Bundles). A total of 11,260 pediatric patients were included. There were 390 episodes of HAIs in 317 patients and the overall rate of HAIs was 6.3 per 1000 patient days. The DA-HAI distribution was: 2.46/1000 CVC days for central-line-associated bloodstream infections (CLABSIs), 5.75/1000 MV days for ventilator-associated pneumonia (VAP) and 3.6/1000 UC days for catheter-associated urinary tract infections (CAUTIs). Comparing the two periods, the HAI rate decreased (p = 0.061) as well as HAI episodes (p = 0.011). The results demonstrate that exposure to devices constitutes an extrinsic risk factor for acquiring HAIs. The multivariate analysis highlights previous bacterial colonization by multidrug-resistant (MDR) bacteria as the most important extrinsic risk factor for HAIs (OR 20.4; 95%CI 14.3–29.1). In conclusion, HAI Zero Bundles have been shown to decrease HAI rates, and the focus should be on the prompt removal of devices, especially in children with important intrinsic risk factors.
Third Trimester Fetuses Demonstrate Priming, a Form of Implicit Memory, In Utero
Authors: Gustafsson Hanna , Hammond Jennifer , Spicer Julie , Kuzava Sierra , Werner Elizabeth , Spann Marisa , Marsh Rachel , Feng Tianshu , Lee Seonjoo , Monk Catherine
Published: October 2022

Research examinations of changes in fetal heart rate (HR) to operationalize fetal memory suggests that human memory capacities emerge in utero. However, there is little evidence for a form of implicit memory or priming. The present aim was to determine if priming is evident in utero. Fetal HR, maternal HR and maternal respiratory rate (RR) were examined in 105 women during the third trimester of pregnancy. Women experienced two counterbalanced laboratory tasks, the Stroop task and the paced breathing task, and their cardiorespiratory activity functioned as a stimulus for fetuses. Repeated measures ANOVAs revealed maternal HR increased during the Stroop task but only when the Stroop task was presented first (89.64 bpm to 92.39 bpm) (p = 0.04). Maternal RR increased during the Stroop task, regardless of task order (17.72 bpm to 21.11 bpm; 18.50 bpm to 22.60 bpm) (p < 0.01). Fetal HR increased during the paced breathing task, but only when it followed maternal exposure to the Stroop task (141.13 bpm to 143.97 bpm) (p < 0.01). Fetuses registered maternal HR and RR reactivity to the Stroop task, which influenced their response during maternal engagement with a related task, suggesting priming. Further study of fetal memory may suggest another pathway by which prenatal exposures impact future development.
Endometriosis in Patients with Mayer-Rokitansky-Küster-Hauser-Syndrome—Histological Evaluation of Uterus Remnants and Peritoneal Lesions and Comparison to Samples from Endometriosis Patients without Mullerian Anomaly
Authors: Steinmacher Sahra , Bösmüller Hans , Granai Massimo , Koch André , Brucker Sara Yvonne , Rall Kristin Katharina
Published: October 2022

Congenital Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a Mullerian-duct anomaly that is characterized by agenesis of the uterus and upper part of the vagina. Uterus remnants of varying sizes can often be found. Although a functional uterus is missing, the existence of endometriosis in this patient group has been described in the literature; however, a histopathological comparison of the characteristics of the endometrium within the uterus remnants versus endometriotic peritoneal lesions in the same patient is lacking. Moreover, the characteristics of endometriotic tissue in patients with MRKH syndrome have not been correlated with those of patients with endometriosis without Mullerian anomaly. Patients who underwent laparoscopic neovagina creation with the removal of uterus remnants and possible resection of endometriotic lesions between 2010 and 2022 at the Department of Women’s health of the University of Tuebingen were included in our study. Uterine remnants and endometriotic tissue were evaluated via histopathology and immunohistochemistry and were compared to endometriotic samples from patients without Mullerian anomaly. Endometriosis was detected in nine MRKH patients; in four patients, endometrial remnants could be sufficiently compared to endometriotic lesions. All samples exhibited increased expression of hormonal receptors. In two patients, Ki67 proliferation index was significantly increased in peritoneal endometriotic lesions compared with the endometrium of the remnants. In contrast, endometrium and endometriotic lesions of endometriosis patients did not exhibit any differences in the Ki67 proliferation index. Our results demonstrate distinctive immunohistochemical variability between uterine remnants and endometriotic lesions in patients with MRKH syndrome compared with patients with endometriosis, indicating a possible explanation model of the yet-unknown etiology of endometriosis. For confirmation, investigation of a broader patient collective is necessary.
Applications and Safety of Sentinel Lymph Node Biopsy in Endometrial Cancer
Authors: Chiu Wan Kam , Kwok Shuk Tak , Wang Yaokai , Luk Hiu Mei , Chan Aaron Hei Yin , Tse Ka Yu
Published: October 2022

Lymph node status is important in predicting the prognosis and guiding adjuvant treatment in endometrial cancer. However, previous studies showed that systematic lymphadenectomy conferred no therapeutic values in clinically early-stage endometrial cancer but might lead to substantial morbidity and impact on the quality of life of the patients. The sentinel lymph node is the first lymph node that tumor cells drain to, and sentinel lymph node biopsy has emerged as an acceptable alternative to full lymphadenectomy in both low-risk and high-risk endometrial cancer. Evidence has demonstrated a high detection rate, sensitivity and negative predictive value of sentinel lymph node biopsy. It can also reduce surgical morbidity and improve the detection of lymph node metastases compared with systematic lymphadenectomy. This review summarizes the current techniques of sentinel lymph node mapping, the applications and oncological outcomes of sentinel lymph node biopsy in low-risk and high-risk endometrial cancer, and the management of isolated tumor cells in sentinel lymph nodes. We also illustrate a revised sentinel lymph node biopsy algorithm and advocate to repeat the tracer injection and explore the presacral and paraaortic areas if sentinel lymph nodes are not found in the hemipelvis.
Design and Evaluation of Unsupervised Machine Learning Models for Anomaly Detection in Streaming Cybersecurity Logs
Authors: Sánchez-Zas Carmen , Larriva-Novo Xavier , Villagrá Víctor A. , Rodrigo Mario Sanz , Moreno José Ignacio
Published: October 2022

Companies, institutions or governments process large amounts of data for the development of their activities. This knowledge usually comes from devices that collect data from various sources. Processing them in real time is essential to ensure the flow of information about the current state of infrastructure, as this knowledge is the basis for management and decision making in the event of an attack or anomalous situations. Therefore, this article exposes three unsupervised machine learning models based on clustering techniques and threshold definitions to detect anomalies from heterogeneous streaming cybersecurity data sources. After evaluation, this paper presents a case of heterogeneous cybersecurity devices, comparing WSSSE, Silhouette and training time metrics for all models, where K-Means was defined as the optimal algorithm for anomaly detection in streaming data processing. The anomaly detection’s accuracy achieved is also significantly high. A comparison with other research studies is also performed, against which the proposed method proved its strong points.
Biofertilizer Based on Biochar and Metal-Tolerant Plant Growth Promoting Rhizobacteria Alleviates Copper Impact on Morphophysiological Traits in Brassica napus L.
Authors: Kumar Adarsh , Borisova Galina , Maleva Maria , Tripti  , Shiryaev Grigory , Tugbaeva Anastasia , Sobenin Artem , Kiseleva Irina
Published: October 2022

Metal tolerant plant growth-promoting (PGP) rhizobacteria are promising for enhancing plant productivity under copper (Cu) stress. Present pot scale experiment was conducted on Brassica napus L. to check the efficiency of rhizobacteria isolated from the rhizosphere of Tussilago farfara L. growing on Cu-contaminated soils. Out of fifty Cu tolerant strains, three isolates which showed multiple PGP traits such as indole-3-acetic acid (IAA) synthesis, phosphate (PS) solubilization, siderophore and ammonia production were identified preliminarily by morphological and physiological characteristics followed by 16S rRNA gene sequencing. The best Bacillus altitudinis strain TF16a which showed IAA: 15.5 mg L−1, PS: 215 mg L−1, siderophore halo zone ratio of 3.0 with high ammonia production was selected to prepare a biochar-based biofertilizer (BF). Seedling test showed maximum growth of B. napus shoot and root in presence of 5% of BF and this concentration was selected for further experiment. The pot experiment included four treatments: control (soil), 100Cu (100 mg Cu kg−1 soil), 5%BF (v/v), and 5%BF+100Cu, which were carried out for 30 days, after which the morphological, physiological, and biochemical parameters of B. napus were studied. The Cu treatment caused its accumulation in shoot and root up to 16.9 and 30.4 mg kg−1 DW, respectively, and increased malondialdehyde (MDA) content by 20%. Application of BF with copper led to the decrease in the Cu accumulation by 20% for shoot and 28% for root while MDA content was the same as in the control. Both treatments of BF with and without Cu increased chlorophyll a and b content by 1.3 times on average as well as non-enzymatic antioxidants such as soluble phenolic compounds (1.3 times) and free proline (1.6 times). Moreover, BF + Cu led to the increase in the biomass of shoot and root by 30 and 60%, respectively, while there was no significant effect on the growth characteristics of plants after the addition of BF without Cu. The study elucidates that BF based on B.altitudinis strain TF16a and biochar can be a promising bioformulation which could increase rapeseed growth under the moderate Cu concentration in soil.
Adsorption of Polyethyleneimine on Fine Arsenopyrite and the Effect on Its Xanthate Flotation
Authors: Ming Pingtian , Xing Qingqing , Wang Zhen , Zhao Kaile , Li Fei , Zou Dan , Guan Youguo
Published: October 2022

Effective flotation of fine particles is a problem for mineral processing. In this paper, a flocculant mostly used in heavy metal ion treatment was used in an arsenopyrite flotation system. The adsorption behavior and flotation performance of PEI on the xanthate flotation of arsenopyrite were investigated through zeta potential and adsorbed amount measurements, XPS and size distribution detections, and micro-flotation tests. Zeta potential results showed that the adsorption of 40 mg/L polyethyleneimine (PEI) caused an increase in the zeta potential of arsenopyrite, and had only a slight depression on the further adsorption of SBX, which was further confirmed by the results of the adsorbed amount measurements. However, when the dosage of PEI was 150 mg/L, the adsorption of SBX was strongly depressed. This was because moderate PEI only bridged different arsenopyrite particles, and most of the active sites for the SBX adsorption were still exposed; when PEI was in excess, the mineral particles would be covered so that there were not enough active sites for SBX adsorption. Fe and As on the mineral surface were the adsorption sites for the PEI molecules, which were resolved from the chemical shifts in the As/Fe peaks of the XPS spectra. PEI can increase particle size, and moderate PEI dosage can make the particle size suitable for flotation with SBX where bridging and hydrophobic effects take place. The flotation results showed that −20 μm arsenopyrite particles had poor flotation recovery with the SBX collector alone, but when they were treated with 40 mg/L PEI, the recovery largely increased. PEI can serve as an effective flocculant for the flocculation flotation of fine arsenopyrite. A comparison model, showing the possible interactions among reagents, particles, and bubbles in the pulp with different PEI dosages, is proposed.
Investigating NAC Transcription Factor Role in Redox Homeostasis in Solanum lycopersicum L.: Bioinformatics, Physiological and Expression Analysis under Drought Stress
Authors: Rai Nagendra , Rai Krishna Kumar , Singh Manish Kumar , Singh Jagdish , Kaushik Prashant
Published: October 2022

NAC transcription factors regulate stress-defence pathways and developmental processes in crop plants. However, their detailed functional characterization in tomatoes needs to be investigated comprehensively. In the present study, tomato hybrids subjected to 60 and 80 days of drought stress conditions showed a significant increase in membrane damage and reduced relative water, chlorophyll and proline content. However, hybrids viz., VRTH-16-3 and VRTH-17-68 showed superior growth under drought stress, as they were marked with low electrolytic leakage, enhanced relative water content, proline content and an enhanced activity of enzymatic antioxidants, along with the upregulation of NAC and other stress-defence pathway genes. Candidate gene(s) exhibiting maximum expression in all the hybrids under drought stress were subjected to detailed in silico characterization to provide significant insight into its structural and functional classification. The homology modelling and superimposition analysis of predicted tomato NAC protein showed that similar amino acid residues were involved in forming the conserved WKAT domain. DNA docking discovered that the SlNAC1 protein becomes activated and exerts a stress-defence response after the possible interaction of conserved DNA elements using Pro72, Asn73, Trp81, Lys82, Ala83, Thr84, Gly85, Thr86 and Asp87 residues. A protein–protein interaction analysis identified ten functional partners involved in the induction of stress-defence tolerance.
Measuring the Operational Efficiency and the Water Resources Management Efficiency for Industrial Parks: Empirical Study of Industrial Parks in Taiwan
Authors: Chiu Chui-Yu , Tang William
Published: October 2022

The efficiency of an industrial park’s operations is an indicator of how well the park can serve the companies located there. These supports include support for environmental water resources and business operations. In this study, a model for measuring water resources management efficiency is developed at the conceptual level using the management mindset of relative efficiency and management by objectives, and a modified Delphi method is used to determine the feasibility of a measurement model for water resources management efficiency. Furthermore, DEA data envelopment analysis was used to analyze the overall operational efficiency of the park. The results of the study showed that the model developed in this study for measuring water resources efficiency is of practical use. In addition, water resource management efficiency can be used as an indicator to assist in the determination of the operating efficiency of the industrial park when it is derived from the DEA analysis. In this study, among the 31 industrial parks in Taiwan, the operating efficiency values were classified into four categories, and the results show that the operating efficiency of most of the industrial parks need to be improved.
Антимонопольное регулирование: приоритеты в меняющемся мире
Authors:   Eurasian Economic Commission., Kachalin Vladimir V.
Published: October 2022

The article focuses on changes in global markets induced by digitalization of economy that caused new challenges to antimonopoly regulation. In this context, the author considers digital platforms and use of algorithmic pricing by economic entities. The author proposes to delineate between different types of platforms and their classification in platforms — exchanges or trade spots and multisided markets and to assess the impact of both types on competition. The article also considers the use of digital algorithms by entities as a factor of concerted conduct and implicit collusion among the market participants. In this context, the author attempts to assess the influence of humans and algorithms on sustainability of implicit collusion. Both problems are considered in the context of global scale of entities. It limits possibilities of law enforcement against their monopolistic conduct by national competition authorities, as well as national sovereignty when faced with global corporations. In conclusion, the author stresses the necessity of search of new means of countering monopolization in digital markets.
The Economic Attack on Russia and the Policy of Counteraction
Authors:   Institute of Economy of the Russian Academy of Sciences., Sukharev Oleg S.
Published: October 2022

The purpose of the study is to show the patterns of the deployment of an economic attack on Russia. The research methodology is a comparative and retrospective analysis, elements of a structural approach. In the course of the analysis, a result was obtained that boils down to the fact that the current model of the world economy with a high level of integration and dependence of the economy poses a threat to the national security of the country. Economic warfare is carried out through damaging sanctions. Good conditions for it were created by the liberal economic policy pursued in Russia, which held back growth. Moreover, such outcomes are typical not only for economic activity, but also for the functioning of science and education — "invisible" sanctions, which creates a long-term perspective of dependent and driven development. It is necessary to ensure control over the distribution of property owners in the domestic market, planning procedures that are reduced to the establishment of thresholds in the field of imports, exports in various areas of activity, as well as the admission of foreign resources and institutional rules to the domestic market. With the implementation of such an institutional policy, sanctions would cause much less damage or their negative effect would be absent. Today, it is necessary to resist the economic attack by maximizing the withdrawal of assets from the dollar denomination, pursuing an anti-devaluation policy, cutting off the banking system from the speculative depreciation game, and intensifying efforts to replace imports in each industry. It is required to close the contours of production to the domestic market with the re-profiling of production, practicing the seizure of foreign property as a response to similar external actions. Such actions require a systematic state policy in all areas of coordination of industries and activities.
The Digital Twin (Artificial Society) of the Socio-Economic System of Russia is a Platform for Experiments in the Field of Managing Demographic Processes
Authors:   Central Economics and Mathematics Institute of the Russian Academy of Sciences, Makarov Valery L. ,   Russian School of Economics,   Lomonosov Moscow State University, Nigmatulin Robert I. ,   Skolkovo Institute of Science and Technology; Institute of Oceanology of the Russian Academy of Sciences; Lomonosov Moscow State University, Ilyin Nikolai I. ,   Central Economics and Mathematics Institute of the Russian Academy of Sciences, Bakhtizin Albert R. ,   Central Economics and Mathematics Institute of the Russian Academy of Sciences, Sushko Elena D. ,   Central Economics and Mathematics Institute of the Russian Academy of Sciences, Sidorenko Milana Yu. ,   State Academic University for the Humanities
Published: October 2022

One of the most promising tools for monitoring and predicting social processes are agent-based models, which are widely used abroad. Their advantage lies in the consideration of the system under study at the level of its individual individuals, which increases the realism of these computer-based assessment methods. In Russia, this direction is also developing, although not so actively. The article discusses the dynamics of the population of Russia, as well as the factors of increasing the birth rate, successful examples of the practical implementation of agent models for studying social processes, a brief description of the model we developed, which includes 146 million agents, is given. With the help of this tool, a forecast of the population of Russia and an assessment of the impact on this indicator of some measures aimed at improving the demographic situation were obtained.
O lugar da “Turma de Creche” numa Escola Municipal de Educação Infantil de Juiz de Fora/Minas Gerais: práticas, tempos e espaços das crianças de três anos de idade
Authors:   , Mello Patrícia Assis Vaz de
Published: October 2022

A presente pesquisa, vinculada à linha de pesquisa Discurso, Práticas, Ideias e Subjetividades em Processos Educativos do Programa de Pós-graduação em Educação da Universidade Federal de Juiz de Fora (UFJF), teve como objetivo investigar o lugar que a “Turma de Creche” ocupa numa Escola Municipal de Juiz de Fora/Minas Gerais, no que tange aos tempos, espaços e práticas voltadas às crianças de três anos de idade. O estudo está ancorado na perspectiva histórico-cultural de Lev Vigotski sobre o desenvolvimento da criança, destacando o papel do meio nesse processo, em diálogo com as ideias de Paulo Freire acerca da educação. Trata-se de uma pesquisa de natureza qualitativa do tipo Estudo de Caso, que utilizou como instrumentos e técnicas de produção de dados a observação participante, a videogravação, a fotografia, a análise documental (Projeto Político-Pedagógico de 2019 e a Proposta Curricular da Rede Municipal de Juiz de Fora de 2010) e a entrevista semiestruturada com a Professora de Referência e a Coordenadora Pedagógica. As observações foram realizadas durante os meses de outubro a dezembro de 2019, duas vezes por semana. Adotou-se como estratégia metodológica a triangulação de dados com vistas a favorecer a maior compreensão do objeto de estudo. O lugar dessa turma na escola foi problematizado a partir do que foi registrado sobre as relações das crianças com os espaços organizados e o planejamento das atividades educativas. Na análise dos dados, fez-se o confronto entre a legislação, as concepções de criança e infância apontadas no Projeto Político-Pedagógico da escola, as falas da professora e coordenadora, e as experiências observadas no chão da escola. As análises indicaram que, apesar de a centralidade das brincadeiras serem reconhecidas nos documentos nacionais e locais sobre o trabalho com as crianças no contexto da Educação Infantil e nas falas dos sujeitos da pesquisa, o brincar se apresenta como atividade secundária ou menor, além de se mostrar escolarizado na organização dos tempos, espaços e materiais. Percebem-se práticas e significados pautados numa educação e cuidado dos corpos para a submissão, a obediência e o controle, indo na contramão das conquistas legais e científicas do campo. Pensar sobre o lugar das crianças de três anos na escola de Educação Infantil é pensar sobre a reapropriação do lugar da criação e da autoria das crianças, suas especificidades de desenvolvimento, e a valorização de práticas comprometidas com as vivências da infância e com o direito à educação de qualidade.
Post-traumatic Stress Disorder and Burnout of Healthcare Providers who cared for Patients with Coronavirus Disease-19 (COVID-19) in a Tertiary General Hospital
Authors: Kim Kyung Deok , Yi Young Hee
Published: October 2022

Purpose : This study aimed to identify post-traumatic stress disorder (PTSD) and burnout experienced by healthcare providers who cared for patients with Coronavirus Disease 2019 (COVID-19) and their influencing factors.Methods : Data were collected from 135 healthcare providers who cared for patients with COVID-19 in a tertiary general hospital from June 8 to September 2, 2021, using a questionnaire. Descriptive statistics, Mann-Whitney U test, Kruskal-Wallis test, t-test, ANOVA and Scheffe’s test, Pearson’s correlation coefficients, and multiple regression were used for analysis using SPSS/WIN 27.0.Results : Participants’ average PTSD score was 9.31 ± 11.80, and 8.9% were in the high-risk group. Participants’ average burnout score was 51.77±21.28, and 62.2% were at high risk. PTSD scores differed significantly according to participants’ age, education, job, position, and current workplace. Burnout scores differed significantly according to their age, gender, marital status, parental status, and education. There was positive correlation between participants’ PTSD and burnout. The factors influencing participants’ PTSD were term of self-isolation and age (R2=.09). There were no significant influencing factors on participants’ burnout.Conclusion : This study reconfirmed that healthcare providers who cared for patients with COVID-19 experienced both PTSD and burnout, suggesting that interventions are needed such as regular pre-training or simulation training and establishing a support system.
Risk Factors and Clinical Outcomes of Unplanned Reintubation after Planned Extubation in Adult Patients admitted to the Intensive Care Unit after Cardiac Surgery
Authors: Lee Ju-Hee , Choi Hye-Ran
Published: October 2022

Purpose : This study aimed to identify risk factors for unplanned reintubation after planned extubation and to analyze the clinical outcomes in patients admitted to the intensive care unit after cardiac surgery.Methods : The study examined patients who underwent intubation and planned extubation admitted to the intensive care unit after cardiac surgery between January 1, 2017, and December 31, 2021. The reintubation group comprised 58 patients underwent unplanned reintubation within 7 days of planned extubation. The maintenance group comprised 116 patients who did not undergo reintubation and were matched with the reintubation group using the rational for matching criteria. Data were collected retrospectively from electronic medical records. We used the independent t-test, Mann-Whitney U test, χ2-test, Fisher’s exact test, and logistic regression analysis with SPSS/WIN 27.0.Results : The multivariate logistic regression analysis demonstrated that albumin (odds ratio [OR]=0.38, 95% confidence interval [CI]=0.20-0.72), surgery time (OR=1.54, 95% CI=1.20-1.97), PaO2 before extubation (OR=0.85 per 10 mmHg, 95% CI=0.75-0.97), postoperative arrhythmia (OR=2.82, 95% CI=1.22-6.51), reoperation due to bleeding (OR=4.65, 95% CI=1.27-17.07), and postoperative acute renal failure (OR=2.97, 95% CI=1.09-8.04) were risk factors for unplanned reintubation. The reintubation group had a higher in-hospital mortality rate (χ2=33.74, p＜.001), longer intensive care unit stay (Z=-7.81, p＜.001), and longer hospital stay than the maintenance group (Z=-8.29, p＜.001).Conclusion : These results identified risk factors and clinical outcomes of unplanned reintubation after planned extubation after cardiac surgery. These findings should be considered when developing and managing an intervention program to prevent and reduce the incidence of unplanned reintubation.
Polypragmasia and interdrug interactions as risk factors of falling in elderly patients
Authors: Ильина Е.С. , Шалыгин В.А. , Богова О.Т. , Потапов В.Н. , Болотокова А.В. , Савельева М.И. , Синицина И.И. , Доскина Е.В. , Сычев Д.А.
Published: October 2022

В статье представлены результаты анализа данных у пациентов многопрофильного стационара старше 75 лет с сердечно-сосудистыми заболеваниями и коморбидными состояниями. Был проведен анализ фармакотерапии геронтологических пациентов, имеющих несколько факторов риска падения, с точки зрения наличия полипрагмазии и межлекарственных взаимодействий, опасных по риску падения. У группы пациентов, испытавших падение в стационаре, по сравнению с пациентами без падения, аудит листов назначений показал преобладание лекарственных средств и их комбинаций, скомпрометированных по повышенному риску этого серьёзного нежелательного явления. Аудит лекарственных назначений пациентам с повышенным риском падений как средство борьбы с полипрагмазией и выявления лекарственных средств, способных вызвать падение, можно проводить с использованием «Светофорной классификации лекарственных средств, повышающих риск падений» и drug-чекера (Drug Interactions Checker интернет-ресурса www.drugs.com) для выявления клинически значимых комбинаций. Использование этих клинико-фармакологических инструментов может способствовать повышению качества и безопасности оказания медицинской помощи в условиях стационара.

This article presents the results of the analysis of data from patients over 75 years of age from a multidisciplinary hospital with cardiovascular disease and comorbid conditions. Pharmacotherapy of gerontological patients with multiple risk factors for falls was analysed in terms of the presence of polypragmasy and drug-drug interactions hazardous to the risk of falls. In the group of patients who experienced a fall in hospital compared to patients without a fall, the prescription lists audit showed a predominance of medicines (drugs) and drug combinations compromised by an increased risk of this serious adverse event. An audit of prescriptions of patients at increased risk of falls as a means of combating polypharmacy and identifying drugs that may cause falls can be conducted using the «Traffic light classification of FRIDs» and drug checkers to identify clinically relevant combinations. The use of these clinical and pharmacological tools can improve the quality and safety of medical care in a hospital setting.
Instagram Filtering Hashtags using the hits Algorithm and Crowd Tagging
Authors: Janarthanan Dr.Vignesh , Keerthana S. , Manideep M. , Sowmya Y. , Kumar Prasanna
Published: October 2022

Instagram is a great place to look for descriptive tags for photographs and other types of information. Inaccordance with the learning by example paradigm, the tags–image pairs can be utilised to train automated image annotation (AIA) systems. In earlier research, we found that, on average. Approximately 22% of Instagram hashtags are related to the image's visual content,accompany, in the sense that they are descriptive hashtags, whereas there are many irrelevant hashtags, in the sense that they are not descriptive hashtags.Stop using hashtags on completely different photographs merely to get more clicks and likes.Enhancement of searchability We provide a revolutionary methodology in this study that is based on the collective intelligence principles that aid in the discovery of those hashtags. We demonstrate this in particular that the use of a modified version of the widely used hyper link induced topic search. In the context of crowd tagging, the (HITS) algorithm provides an effective and consistent method for locating pairs of Instagram photographs and hashtags, resulting in representative and noise-free results. Content-based image retrieval training sets We used crowdsourcing as a proof of concept platform Figure-eight to enable for the collection of collective intelligence in the form of tag selection.For Instagram hashtags, this is known as (crowdtagging). Figure-crowdtagging eight's data is utilised to create bipartite networks in which the first kind of node relates to the annotators and the second type of node corresponds to the annotations input the hashtags they've chosen. The HITS algorithm is used to rank the annotators in the first place,in terms of their efficiency in the crowdtagging activity, and then to find the appropriate hashtags for each situation image.
Sağlık Bilimleri Fakültesi Acil Yardım ve Afet Yönetimi Bölüm Öğrencilerinin Afetlere Bireysel Dirençliliklerinin Değerlendirilmesi: Çanakkale ve Aksaray Örneği
Authors: AKİL Kübra , INAL ONAL Ebru
Published: October 2022

Afetler küresel boyutta kabul edilemez bir risk düzeyindedir. Afetlerden mümkün olan en az şekilde zarar görebilmek için ise bireylerin ve toplumların incinebilirliklerinin azaltılıp, dirençliliklerinin arttırılması gereklidir. Özellikle afetlerde görev yapacak saha çalışanlarının dirençliliklerinin yüksek olması çok önemlidir. Bu çalışmada Çanakkale Onsekiz Mart Üniversitesi ve Aksaray Üniversitesi’nde yer alan Acil Yardım ve Afet Yönetimi bölümü öğrencilerinin afetlere bireysel dirençliliklerinin değerlendirilmesi amaçlanmıştır. Araştırmanın verileri sosyodemografik özellikleri ve afet deneyimlerinden oluşan 17 soruluk bir anket formu ile “Bireysel Afet Dirençlilik Değerlendirme Ölçeği” (20 madde) kullanılarak toplanmıştır. Verilerin analizinde tanımlayıcı istatistikler ile t test ve One-Way Anova Testi uygulanmıştır. Çalışmaya katılan öğrencilerin cinsiyetleri, ailelerinin ekonomik durumu ve kardeş sayıları ile afetlere bireysel dirençlilikleri arasında anlamlı bir ilişki bulunmuştur (p<0,05). Kadınların, az kardeşe sahip olanların ve ailesinin ekonomik durumu iyi olanların afetlere bireysel dirençlilikleri puan ortalamaları daha yüksek bulunmuştur. Kadınların her alanda güçlendirilmesi için eğitim şarttır. Afetlerde direncin arttırılması ve kırılganlıkların azaltılması için en temel faktör eğitimdir.
Dinar (Afyonkarahisar, Batı Türkiye) Bölgesindeki Kömür Oluşumlarının Uranyum Potansiyeli: Uranyum Birikimini Kontrol Eden Jeolojik Faktörler
Authors: SOYLU Anıl , DONER Zeynep , UNLUER Ali Tugcan , FİŞNE Abdullah , KUMRAL Mustafa
Published: October 2022

Dünyada enerji kaynaklarının rastgele dağılmış olması, yükselen enerji fiyatları, küresel ısınma ve iklim değişikliği gibi çevresel sorunlar, yakın gelecekte fosil yakıtların tükenecek olması, bu enerji kaynaklarının çevre ve insan sağlığı üzerindeki etkileri, yabancı kaynaklara ve az sayıda enerji zengini ülkeye bağımlılık sebebiyle ülkeler farklı enerji kaynaklarına yönelmiştir. Uranyumu yakıt olarak kullanan nükleer enerji üretimi Türkiye için alternatif bir kaynak olarak ele alınmaktadır. Türkiye’nin kanıtlanmış uranyum rezervi 32.4 kiloton olup, halen uranyum içerebilecek havzaların araştırılması devam etmektedir. Bu kapsamda, Pliyo-Miyosen genişlemeli rejim sonucu gelişen Dinar (Afyonkarahisar, Batı Anadolu) kömür oluşumları ekonomik açıdan önem arz edebilecek uranyum içerikleri bakımından ilgi çekebilmektedir. Çeşitli derinliklerden ve 5 sondaj kuyusundan toplam 17 adet kömür numunesi alınmıştır. Bu numunelerin uranyum içeriklerinin 1065 μg/g mertebelerine kadar çıktığı görülmüştür. Havzada mevcut olan uranyumun, kömürleşme süreci ve kömür tabakalarının üzerinin volkanoklastik sedimanlar tarafından örtülmesinden sonra, hidrotermal akışkanlar ile karışan yeraltı sularının etkisiyle katmanlı epijenetik köken modeline uygun şekilde oluştuğu düşünülmektedir. Ayrıca, yüksek uranyum içeriğinin, linyit damarlarının üst katmanlarında yoğunlaşması sebebiyle havza diğer epijenetik linyit oluşumları ile benzerlik göstermektedir.