bluuebunny/crossref_metadata_2025 huggingface dataset:
Satellite DNAs, heterochromatin, and sex chromosomes of the wattled jacana (Charadriiformes; Jacanidae): a species with highly rearranged karyotype
Authors: de Oliveira Alan Moura , Souza Guilherme Mota , Toma Gustavo Akira , dos Santos Natalia , dos Santos Rodrigo Zeni , Goes Caio Augusto Gomes , Deon Geize Aparecida , Setti Princia Grejo , Porto-Foresti Fábio , Utsunomia Ricardo , Gunski Ricardo José , Del Valle Garnero Analía , Herculano Correa de Oliveira Edivaldo , Kretschmer Rafael , Cioffi Marcelo de Bello
Published: February 2024

Charadriiformes, which comprises shorebirds and their relatives, is one of the most diverse avian orders, with over 390 species showing a wide range of karyotypes. Here, we isolated and characterized the whole collection of satellite DNAs (satDNAs) at both molecular and cytogenetic levels of one of its representative species, named the wattled jacana ( Jacana jacana), a species that contains a typical ZZ/ZW sex chromosome system and a highly rearranged karyotype. In addition, we also investigate the in situ location of telomeric and microsatellite repeats. A small catalog of 11 satDNAs was identified that typically accumulated on microchromosomes and on the W chromosome. The latter also showed a significant accumulation of telomeric signals, being (GA)10 the only microsatellite with positive hybridization signals among all the 16 tested ones. These current findings contribute to our understanding of the genomic organization of repetitive DNAs in a bird species with high degree of chromosomal reorganization contrary to the majority of bird species that have stable karyotypes.
Systematics of fully heavy dibaryons
Authors: Weng Xin-Zhen , Zhu Shi-Lin
Published: February 2024

We systematically study the mass spectra of the fully heavy dibaryons in an extended chromomagnetic model, which includes both the colorelectric and chromomagnetic interactions. We find no stable state below the corresponding baryon–baryon thresholds. Besides the masses, we also estimate the relative width ratios of the two-body decay channels. We hope our study will be of help for future experiments.
Relativistic orbits of S2 star in the presence of scalar field
Authors: Bambhaniya Parth , Joshi Ashok B. , Dey Dipanjan , Joshi Pankaj S. , Mazumdar Arindam , Harada Tomohiro , Nakao Ken-ichi
Published: February 2024

The general theory of relativity predicts the relativistic effect in the orbital motions of S-stars which are orbiting around our Milky-way Galactic Center. The post-Newtonian or higher-order approximated Schwarzschild black hole models have been used by GRAVITY and UCLA Galactic Center groups to carefully investigate the S2 star’s periastron precession. In this paper, we investigate the scalar field effect on the orbital dynamics of S2 star. Hence, we consider a spacetime, namely Janis-Newman-Winicour (JNW) spacetime which is seeded by a minimally coupled, mass-less scalar field. The novel feature of this spacetime is that one can retain the Schwarzschild spacetime from JNW spacetime considering zero scalar charge. We constrain the scalar charge of JNW spacetime by best fitting the astrometric data of S2 star using the Monte-Carlo–Markov-Chain (MCMC) technique assuming the charge to be positive. Our best-fitted result implies that similar to the Schwarzschild black hole spacetime, the JNW naked singularity spacetime with an appropriate scalar charge also offers a satisfactory fitting to the observed data for S2 star. Therefore, the JNW naked singularity could be a contender for explaining the nature of Sgr A* through the orbital motions of the S2 star.
Wormhole effective mass and gravitational waves by binary systems containing wormhole
Authors: Kim Sung-Won
Published: February 2024

We considered the generation of gravitational waves by the binary system associated with a wormhole. In the Newtonian limit, the gravitational potential of a wormhole requires the effective mass of the wormhole taking into account radial tension effects. This definition allows us to derive gravitational wave production in homogeneous and heterogeneous binary systems. Therefore, we studied gravitational waves generation by orbiting wormhole–wormhole and wormhole–black hole binary systems before coalescence. Cases involving negative mass require more careful handling. We also calculated the energy loss to gravitational radiation by a particle orbiting around the wormhole and by a particle moving straight through the wormhole mouth, respectively.
Efficiency and energy resolution of gamma spectrometry system with HPGe detector depending on variable source-to-detector distances
Authors: Hafızoğlu Nurgül
Published: February 2024

The high-purity germanium (HPGe) detectors, which are one of the basic instruments in the experimental nuclear physics, are widely used in many areas such as the environmental radioactivity, neutron activation analysis and geology. This study reports the results of energy calibration, energy resolution and efficiency calculations for an HPGe detector (ORTEC), which are necessary to determine the quality of the measurement results obtained from a gamma spectrometry system. For the purpose of examining the effects of gamma-ray energy and the distance between the source and the detector on the detector efficiency, measurements were made at six different source–detector distances for a total of about fourteen energies of the point sources (133Ba, 109Cd, 137Cs, 57Co, 60Co, 152Eu, 22Na, and 65Zn). Basic data were obtained with this detector system for later studies.
The a Priori Procedure (APP) for Estimating the Cohen’s Effect Size for Matched Pairs Under Skew Normal Settings
Authors: Cao Lixia , Wang Cong , Chen Xiangfei , Trafimow David , Wang Tonghui
Published: February 2024

The a priori procedure (APP) provides minimum sample sizes to meet specifications for precision and confidence that, in turn, can enhance trust that the sample statistics to be obtained provide good estimates of corresponding population parameters. A recent advance by Chen et al.3 showed how to perform the APP with respect to Cohen’s [Formula: see text], which is the most popular effect size measure in the social sciences. However, a limitation is that Chen et al.3 assumed normal distributions that compose only a subset of the much larger family of skew normal distributions, which are used as distributions of random errors in many economical models such as stochastic frontier models that are popular and useful models to investigate production efficiency in microeconomics, see Hung.5 Therefore, it would be useful to generalize to skew normal distributions. We perform the mathematical derivations for the generalization and support them with simulations and worked examples. Finally, we provide a free and user-friendly computer program by which researchers can perform the APP to determine minimum sample sizes necessary to meet specifications for precision and confidence, with respect to Cohen’s [Formula: see text], for a matched sample under the large umbrella of skew normal distributions.
Why Markov Switching Models Work Well: An Explanation
Authors: Yamaka Woraphon , Bokati Laxman
Published: February 2024

In general, the probability of the next state depends not only on the current state, but also on the whole pre-history. However, in practice, many real-life processes — including economic processes — can be well described by so-called Markov models, i.e., models in which the probability of the next state depends only on the current state. In this paper, we explain the empirical ubiquity of such models.
A New Inverse Extended Weibull Distribution for Modelling Insurance Loss Data
Authors: Yu Shilin , Li Xuan , Choy S. T. Boris
Published: February 2024

This paper proposes a new three-parameter inverse Weibull-type distribution via a similar way of constructing a skew normal distribution. The additional shape parameter increases the distribution’s modelling capability as other three-parameter inverse Weibull-type distributions. The mathematical properties of this inverse extended Weibull distribution are studied and proven. In the empirical study of four insurance datasets from Australia, Denmark and the USA, we show that the proposed distribution performs very well compared with other three-parameter competitors.
Quantum Entropy and the Mechanism of Gravity
Authors: Watson Christopher N.
Published: February 2024

Quantum entropy measures the number of possible microstates of position and momentum due to quantum uncertainty. Black hole entropy is an example of quantum entropy. Classical entropy, like the Gibbs entropy of a gas, does not depend on quantum uncertainty. This paper is the first to define the quantum entropy of ordinary matter, termed “atomic entropy”. The atomic entropy at the surface of a spherical object depends on its mass and is inversely proportional to its surface area. The entropy scale factor (ESF) is a theory that all changes in the scale of spacetime are due to differences in entropy. Defining atomic entropy allows the ESF to make predictions for systems including ordinary matter. In the ESF, gravitational objects are attracted to one another because gravitational entropy, a form of quantum entropy, increases as the distance between these objects decreases. The increase in gravitational entropy increases the total entropy of the system, in accordance with the second law of thermodynamics. This paper is also the first to use the gradients in the scale of space and time predicted by the ESF to derive Newtonian gravity. Explaining the mechanism of gravity in this way provides a link between quantum physics and gravity.
A Unifying Framework for Incompleteness, Inconsistency, and Uncertainty in Databases
Authors: Kimelfeld Benny , Kolaitis Phokion G.
Published: February 2024

Deploying possible world semantics and the challenge of computing the certain answers to queries.
Entity Footprinting: Modeling Contextual User States via Digital Activity Monitoring
Authors: R. Yousefi Zeinab , Vuong Tung , AlGhossein Marie , Ruotsalo Tuukka , Jaccuci Giulio , Kaski Samuel
Published: February 2024

Our digital life consists of activities that are organized around tasks and exhibit different user states in the digital contexts around these activities. Previous works have shown that digital activity monitoring can be used to predict entities that users will need to perform digital tasks. There have been methods developed to automatically detect the tasks of a user. However, these studies typically support only specific applications and tasks, and relatively little research has been conducted on real-life digital activities. This article introduces user state modeling and prediction with contextual information captured as entities, recorded from real-world digital user behavior, called
entity footprinting
—a system that records users’ digital activities on their screens and proactively provides useful entities across application boundaries without requiring explicit query formulation. Our methodology is to detect contextual user states using latent representations of entities occurring in digital activities. Using topic models and recurrent neural networks, the model learns the latent representation of concurrent entities and their sequential relationships. We report a field study in which the digital activities of 13 people were recorded continuously for 14 days. The model learned from this data is used to (1) predict contextual user states and (2) predict relevant entities for the detected states. The results show improved user state detection accuracy and entity prediction performance compared to static, heuristic, and basic topic models. Our findings have implications for the design of proactive recommendation systems that can implicitly infer users’ contextual state by monitoring users’ digital activities and proactively recommending the right information at the right time.
Seq2Set2Seq: A Two-stage Disentangled Method for Reply Keyword Generation in Social Media
Authors: Liu Jie , Li Yaguang , He Shizhu , Wu Shun , Liu Kang , Liu Shenping , Wang Jiong , Zhang Qing
Published: February 2024

Social media produces large amounts of content every day. How to predict the potential influences of the contents from a social reply feedback perspective is a key issue that has not been explored. Thus, we propose a novel task named reply keyword prediction in social media, which aims to predict the keywords in the potential replies in as many aspects as possible. One prerequisite challenge is that the accessible social media datasets labeling such keywords remain absent. To solve this issue, we propose a new dataset,

1

to study the reply keyword prediction in social media. This task could be seen as a single-turn dialogue keyword prediction for open-domain dialogue system. However, existing methods for dialogue keyword prediction cannot be adopted directly, which has two main drawbacks. First, they do not provide an explicit mechanism to model topic complementarity between keywords which is crucial in social media to controllably model all aspects of replies. Second, the collocations of keywords are not explicitly modeled, which also makes it less controllable to optimize for fine-grained prediction since the context information is much less than that in dialogue. To address these issues, we propose a two-stage disentangled framework, which can optimize the complementarity and collocation explicitly in a disentangled fashion. In the first stage, we use a sequence-to-set paradigm via multi-label prediction and determinantal point processes, to generate a set of keyword seeds satisfying the complementarity. In the second stage, we adopt a set-to-sequence paradigm via seq2seq model with the keyword seeds guidance from the set, to generate the more-fine-grained keywords with collocation. Experiments show that this method can generate not only a more diverse set of keywords but also more relevant and consistent keywords. Furthermore, the keywords obtained based on this method can achieve better reply generation results in the retrieval-based system than others.
Synthesis and Characterization of Flower-Like Cobalt-Doped ZnO Nanostructures for Ammonia Sensing Applications
Authors: Himabindu B. , Latha Devi N. S. M. P. , Nagaraju P. , Kanth B. Rajini
Published: February 2024

The future trajectory of gas sensor development focuses mainly on two key aspects: minimizing power consumption and enhancing the capability to detect hazardous gases at lower concentrations under ambient conditions. The present study used the co-precipitation method to explore the synthesis of zinc oxide and cobalt-doped ZnO sensors, encompassing a range of cobalt concentrations from 1 wt% to 4 wt%. The synthesized samples undergo comprehensive analysis to evaluate their structural, morphological, optical, and gas-sensing properties. X-ray Diffraction (XRD) revealed a hexagonal Wurtzite structure, and the crystallite size decreased from 16.92 to 15.39 nm. Energy-Dispersive X-ray spectroscopy (EDX) and Fourier-Transform Infrared (FTIR) Spectroscopy collectively affirmed the presence of cobalt. Scanning Electron Microscopy (SEM) was used to analyze the morphological characteristics. The Tauc-plot was used to determine the optical bandgap via diffuse reflectance spectroscopy. As cobalt doping increased, the band gap increased from 3.18 to 3.23 eV. Further, Atomic Force Microscopy (AFM) and Brunauer–Emmett–Teller (BET) analysis were used to assess the surface topography and pore size distribution. The AFM measurements indicated roughness increased from 435 to 700 nm. The BET analysis revealed mesoporous properties, with surface area increased from 18.657 to 21.962 m2/g and pore sizes varying from 3.67 to 3.72 nm. Subsequently, the gas-sensing capabilities of the Co-doped ZnO sensors were examined for various volatile organic compounds (VOCs) at room temperature. The experimental results demonstrated excellent performance in detecting NH3 gas precisely. The sensor with 4% cobalt doping exhibited a fast response and recovery time of 21 and 20 s towards 2 ppm of NH3.
Control of Alternaria Leaf Spot of the Common Bean (Phaseolus vulgaris L.) Using Soil-Derived Biological Agents
Authors: Karonji Stella , Odhiambo Nixon Odiwuor , Muli Joshua Kiilu , Mugweru Julius , Mwirichia Romano
Published: February 2024

Phaseolus vulgaris L. is considered one of the most essential legume crops in Kenya. Alternaria alternata is an economically significant plant pathogen that causes Alternaria leaf spot which accounts for over 70% yield losses of beans in Kenya. Chemical fungicides based on copper and sulfur are used to control Alternaria leaf spot in bean plants, but their prolonged use has adversely affected the environment and the health of workers. Herein, we tested the biocontrol potential of bacterial agents from soil planted with Rosecoco bean plants infected with A. alternata. Using bacterial suspensions at different time intervals, we evaluated the putative bacterial biocontrol activity against A. alternata under greenhouse conditions. B. subtilis and B. velezensis bacterial biocontrol agents significantly suppressed disease severity by 20% and 21.2% on the 45th day, respectively. Our study demonstrates that B. subtilis and B. velezensis are promising biocontrol agents that could be integrated in the management of Alternaria leaf spot.
Existence, Blow-Up, and Blow-Up Rate of Weak Solution to Fourth-Order Non-Newtonian Polytropic Variation-Inequality Arising from Consumption-Investment Models
Authors: Li Jia , Bai Xuelian
Published: February 2024

This article obtains the conditions for the existence and nonexistence of weak solutions for a variation-inequality problem. This variational inequality is constructed by a fourth-order non-Newtonian polytropic operator which is receiving much attention recently. Under the proper condition of the parameter, the existence of a solution is proved by constructing the initial boundary value problem of an ellipse by time discretization and some elliptic equation theory. Under the opposite parameter condition, we analyze the nonexistence of the solution. The results show that the weak solution will blow up in finite time. Finally, we give the blow-up rate and the upper bound of the blow-up time.
Impact of Using Processed Urinary Bladder Submucosa and Hydrogel Fabricated from Tendon on Skin Healing Process in Rabbits
Authors: Alkhilani Majid A. , Hammoodi Omar Tariq , Emran Hasanain Abduljabbar , Alhayani Wissam Abdullah
Published: February 2024

This study was intended to evaluate the healing of skin injury by using decellularized urinary bladder submucosa scaffolds and tendon‐derived hydrogel. Thirty‐six adult local breeds of both sex rabbits, with an average weight of 2.0–2.5 kg, were divided randomly into three groups (12 animals for each group). All groups were subjected to an induced injury (2 cm) in diameter at the right side of the abdominal skin, the rabbits of the 1st group (A) were sutured without the application of any substance as a control group, the rabbits of the 2nd group (B) were sutured and treated with the application of decellularized urinary bladder submucosa scaffolds, and in the 3rd group (C), they were sutured and treated with the application of tendon‐derived hydrogel. Postoperative care following had been done for all groups throughout the study period. Specimens from the injured skin were taken for the histopathological study on the postinjury day, 8th, 14th, 21st, and 24th. The study showed a clear effect of materials used in the treatment of wounds through a clear progression in the healing stages with a noticed superiority of the submucosa scaffold group.
Comparative Ranking Preferences Decision Analysis through a Novel Fuzzy TOPSIS Technique for Vehicle Selection
Authors: Dharmalingam Marimuthu , Mahapatra G. S. , Georgise Fasika Bete , Deb Mahuya
Published: February 2024

Acquiring a vehicle or financing its purchase is often considered a luxury, particularly for middle‐class households. In addition to their primary concern, consumers prioritize distinguishing elements such as vehicle type, size, capacity, engine power, fuel efficiency, safety features, and life‐cycle costs. Furthermore, the choice of vehicle has multiple factors and is contingent upon the financial prosperity of the household, allowing for precise expression. The decision‐making process is complex and entails selecting the most appropriate alternatives. This study proposes a novel fuzzy technique for order of preference by similarity to the ideal solution (FTOPSIS) method to solve vehicle selection multi‐criteria decision‐making (MCDM) problems. Decision‐makers express their opinions on each alternative and criterion in linguistic terms, in terms of generalized interval type‐2 trapezoidal fuzzy numbers (GIT2TrFNs). The FTOPSIS process involved utilizing the defuzzification of GIT2TrFNs to acquire the normalization matrix. Finally, the proposed approach prioritizes the options and chooses the best vehicle when faced with conflicting criteria, as illustrated through a numerical illustration.
A Comprehensive Exploration of Bioluminescence Systems, Mechanisms, and Advanced Assays for Versatile Applications
Authors: Dunuweera Asiri N. , Dunuweera Shashiprabha P. , Ranganathan K.
Published: February 2024

Bioluminescence has been a fascinating natural phenomenon of light emission from living creatures. It happens when the enzyme luciferase facilitates the oxidation of luciferin, resulting in the creation of an excited-state species that emits light. Although there are many bioluminescent systems, few have been identified. D-luciferin-dependent systems, coelenterazine-dependent systems, Cypridina luciferin-based systems, tetrapyrrole-based luciferins, bacterial bioluminescent systems, and fungal bioluminescent systems are natural bioluminescent systems. Since different bioluminescence systems, such as various combinations of luciferin-luciferase pair reactions, have different light emission wavelengths, they benefit industrial applications such as drug discovery, protein-protein interactions, in vivo imaging in small animals, and controlling neurons. Due to the expression of luciferase and easy permeation of luciferin into most cells and tissues, bioluminescence assays are applied nowadays with modern technologies in most cell and tissue types. It is a versatile technique in a variety of biomedical research. Furthermore, there are some investigated blue-sky research projects, such as bioluminescent plants and lamps. This review article is mainly based on the theory of diverse bioluminescence systems and their past, present, and future applications.
Evaluation of Activated Carbons Prepared from Bioprecursors for the Removal of Cadmium and Chromium (VI)
Authors: Touzani Ibrahim , El Machrafi Imane , Harboul Kaoutar , Boudouch Otmane , Alouiz Imad , Hammani Khalil , Flouchi Rachid , Fikri-Benbrahim Kawtar
Published: February 2024

Trace metals found in industrial effluents are highly toxic pollutants, and these include cadmium and chromium (VI). The objective of this work is to remove cadmium and chromium (VI) on activated carbons, prepared from biomaterials such as nuclei of Ziziphus lotus and coffee grounds. The characterization of adsorbents was performed by scanning electron microscopy (SEM) and X-ray diffraction (XRD). The results of the characterization showed an important porosity on the activated carbon’s surface, with sizes between 6 and 50 μm. Similarly, the adsorption results showed that the adsorption process is very rapid and that the increase in contact time and temperature improves the efficiency of the Cd and Cr(VI) removal process. Indeed, abatement rates (R%) of 80% for Cr(VI) and 60% for Cd were obtained after 80 minutes of adsorption on activated carbon prepared from Ziziphus lotus, whereas activated carbon obtained from coffee grounds allows a reduction rate of about 50% for Cr(VI) and Cd. Hence, it seems clearly that the activated carbon of Ziziphus lotus is more effective than that of coffee grounds, especially for the Cr(VI) adsorption. The kinetic modeling of the adsorption process followed the pseudo-second-order model, and the Freundlich model has better explained the adsorption isotherm for Cd and Cr(VI). The thermodynamic study showed that adsorption was spontaneous and endothermic.
Effect of Phonological and Phonetic Interventions on Proficiency in English Pronunciation and Oral Reading
Authors: Prahaladaiah Diwakar , Andrew Thomas Kennedy
Published: February 2024

The current research aimed to know the effect of phonological and phonetic interventions in enhancing proficiency in English pronunciation and oral reading among teacher trainees. This study was of single-group pretest and posttest intervention designs. The sample size was selected through a stratified random sampling technique from teacher training colleges in Bengaluru. Two hundred and seven teacher trainees with L1 proficiency were chosen proportionately from Bangalore strata and orientated. Participants (N = 32) enrolled voluntarily in the intervention program for 20 hr. Intervention modules on phonology and phonetics were developed by the researcher and a segmental approach was adopted to teach modules in 20 sessions. After every session, the participants were allowed to record the modules in Audacity, a multiaudio recorder application. The recorded modules were interpreted, and scores were determined on number of intelligible words pronounced by the participants. Further, it was validated by the experts to authenticate the determined scores. The researcher applied oscillographic and observation methods to analyze the participants’ progress in pronunciation and oral reading proficiency levels during the experiment. The Wilcoxon signed-rank test was used to test the impact of intervention between the pretest and posttest (before and after intervention). The hypotheses testing revealed the difference between preintervention and postintervention scores in phonological and phonetic awareness and oral reading among teacher trainees, and the sig. value is less than 0.05 across all the attributes. This study insists that English phonology and phonetics must be a crucial part of the English language teaching (ELT) curriculum and highlights that teachers must be able to spot the most appropriate pronunciation teaching and train the students of English as a foreign language (EFL) with intricates of intelligible pronunciation. This study navigates the need for language proficiency among teacher trainees, especially in English pronunciation and oral reading, and substantiates the evidence that effective intervention and teachers’ knowledge of pronunciation enhance proficiency levels in pronunciation and oral reading among teacher trainees. Finally, it hopes that B.Ed colleges and teacher educators will be beckoned to use technology-integrated intervention to teach phonology and phonetics.
Endoscopic Thyroidectomy for Large-Sized Goiters: Merits of the Axillo-Breast Approach with Gas Insufflation
Authors: Elzahaby Islam A. , Ali Essam Attia , Farid Ahmed Mohammed , Ghaffar Saleh Mohamed Abd El , Abdallah Ahmed
Published: February 2024

Background. Several minimal access approaches to the thyroid gland have been widely applied; nevertheless, such approaches are still challenging when dealing with large-sized thyroid nodules or goiters. We hereby evaluated the outcomes and highlighted the merits of endoscopic axillo-breast hemithyroidectomy (EABH) for large-sized unilateral goiters. Methods. Patients underwent EABH for unilateral large thyroid nodules ≥6 cm in its greatest dimension or unilateral large goiter (≥60 ml sonographic volume) whatever the size of its contained nodules were identified from a prospectively maintained database. Their demographic data, clinicopathological profiles, and surgical and esthetic outcomes are reported and analyzed. Results. Over a 2-year period, 33 patients matched the selection criteria. Their mean age was 34.75 ± 11.39 years. There were 30 women and 3 men. The majority of nodules were radiologically TIRADS3 and cytologically Bethesda 3. The mean sonographic dominant nodule greatest dimension was 5.29 ± 1.48 cm (range: 3–9.5 cm). The mean sonographic volume of the pathological lobe was 101.86 ± 54.45 ml (range: 60.11–236.88 ml). All cases were completed endoscopically with no conversion to open. The mean operative time was 110.76 ± 18.75 minutes. No significant postoperative complications were reported except for one case with temporary vocal cord paresis. Most (87.9%) of the patients were extremely satisfied with the procedure. Conclusion. EABH with our suggested key steps could be considered an effective valid approach for unilateral large goiters in trained hands and in patients desirous for cosmesis.
Network Pharmacology Analysis of the Therapeutic Potential of Colchicine in Acute Lung Injury
Authors: Sun Fei , Zhang Lijuan , Shen Lulu , Wang Chunman
Published: February 2024

Background. This study employed integrated network pharmacology approach to explore the mechanisms underlying the protective effect of colchicine against acute lung injury (ALI). Methods. We analyzed the expression profiles from 13 patients with sepsis-related ALI and 21 controls to identify differentially expressed genes and key modules. ALI-related genes were curated using databases such as DisGeNET, Therapeutic Target, and Comparative Toxicogenomics Database to curate ALI-related genes. Drug target fishing for colchicine was conducted using the DrugBank, BATMAN-TCM, STITCH, and SwissTargetPrediction. Potential drug-disease interactions were determined by intersecting ALI-associated genes with colchicine target genes. We performed comprehensive pathway and process enrichment analyses on these genes. A protein-protein interaction network was constructed, and topological analysis was executed. Additionally, an ALI mouse model was established to evaluate the effect of colchicine on CXCL12 and CXCR4 levels through western blot analysis. Results. Analysis revealed 23 potential colchicine-ALI interaction genes from the intersection of 253 ALI-associated genes and 389 colchicine targets. Functional enrichment analysis highlighted several inflammation-related pathways, such as cytokine-mediated signaling pathway, CXCR chemokine receptor binding, NF-kappa B signaling pathway, TNF signaling pathway, and IL-17 signaling pathway. The protein-protein interaction network demonstrated complex interactions for CXCL12 and CXCR4 among other candidate genes, with significant topological interaction degrees. In vivo studies showed that colchicine significantly reduced elevated CXCL12 and CXCR4 levels in ALI mice. Conclusion. Our findings suggest that colchicine’s therapeutic effect on ALI might derive from its anti-inflammatory properties. Further research is needed to explore the specific mechanisms of colchicine’s interaction with sepsis-induced ALI.
Supplementary Table S7 from Genetic Factors and Long-term Treatment-Related Neurocognitive Deficits, Anxiety, and Depression in Childhood Leukemia Survivors: An Exome-Wide Association Study
Authors: Petrykey Kateryna , Lippé Sarah , Sultan Serge , Robaey Philippe , Drouin Simon , Affret-Bertout Laurence , Beaulieu Patrick , St-Onge Pascal , Baedke Jessica L. , Yasui Yutaka , Hudson Melissa M. , Laverdière Caroline , Sinnett Daniel , Krajinovic Maja
Published: February 2024

Multivariable regression analysis for the Moderate-severe anxiety, male participants.
Figure S2 from Potential for Cure by Stage across the Cancer Spectrum in the United States
Authors: Hubbell Earl , Clarke Christina A. , Smedby Karin E. , Adami Hans-Olov , Chang Ellen T.
Published: February 2024

Median cure fraction by cancer type and stage at diagnosis,
stratified by age group from 40–84 years at diagnosis from 2006–2015, followed for
mortality through 2020, Surveillance, Epidemiology, and End Results (SEER) 17
registries
Supplementary Figure S3 from The Influence of Smoking and Occupational Risk Factors on DNA Methylation in the AHRR and F2RL3 Genes
Authors: Pelland-St-Pierre Laura , Pham Michael C. , Nguyen Alice Quynh Huong , Pasquet Romain , Taylor Sherryl A. , Bosson-Rieutort Delphine , Koushik Anita , Ho Vikki
Published: February 2024

Supplementary Figure S3 shows, for each graph, the effect estimate and the 95% CI plotted across all 33 CpG sites in the AHRR gene. Multivariable models included adjustment for age, phase of blood sampling, education level, ethnicity,
and smoking (CSI - cumulative smoking index). The interpretation of the effect estimate is the difference in mean methylation
level relative to those never exposed to each agent (reference group). Categorization of occupational exposures was based on the FWI as
never exposed (FWI=0, reference group), Low exposure (>0 and lower than the population median, in blue square) and High
exposure (≥population median, in red triangle). * Denotes a p-value < 0.05.
Data from Patterns of Anticoagulation Use and All-Cause of Mortality in Cancer Patients with Atrial Fibrillation
Authors: Han Xu , Yang Xiaolei , Hidru Tesfaldet H. , Wang Chengfang , Xia Yunlong
Published: February 2024

AbstractBackground:
There is uncertainty regarding the clinical benefit of anticoagulant (AC) treatment in patients with cancer with atrial fibrillation (AF). We aimed to evaluate the distribution and patterns of AC use and its impact on all-cause mortality in cancer patients with AF.
Methods:
A total of 1,653 patients with cancer diagnosed with AF were included in this retrospective cohort analysis. Multivariable logistic regression was applied to identify the clinical predictors of anticoagulant prescription. Kaplan–Meier curve with a log-rank test was used to compare the probability of survival between the AC and non-AC groups. Multivariate Cox proportional hazard regression models were implemented to evaluate the influences of various variables on all-cause death.
Results:
Of 1,653 patients with cancer with AF, 971 (58.7%) did not receive a prescription for AC. Among patients with CHA2DS2-VASC ≥2 in men or ≥3 in women and HAS-BLED <3, 56.5% were not prescribed AC. Rivaroxaban and warfarin are more frequently used than dabigatran, mainly in patients with lung and breast cancer. Over a median follow-up of 36 months, 776 deaths were identified. The Kaplan–Meier curve suggested that patients with AC prescriptions had better clinical outcomes. On multivariate Cox proportional risk regression analysis, AC prescription was significantly associated with a lower risk of all-cause mortality (hazard ratio, 0.78; 95% confidence interval, 0.66–0.91; P = 0.002).
Conclusions:
The prescription of anticoagulants in patients with cancer with AF was suboptimal. AC prescription at discharge was associated with a decreased risk of all-cause mortality.
Impact:
This study highlights the importance of AC prescriptions in patients with cancer with AF.
Discovery and Preclinical Activity of BMS-986351, an Antibody to SIRPα That Enhances Macrophage-mediated Tumor Phagocytosis When Combined with Opsonizing Antibodies
Authors: Chan Henry , Trout Christina V. , Mikolon David , Adams Preston , Guzman Roberto , Mavrommatis Konstantinos , Abbasian Mahan , Hadjivassiliou Haralambos , Dearth Lawrence , Fox Brian A. , Sivakumar Pallavur , Cho Ho , Hariharan Kandasamy
Published: February 2024

In normal cells, binding of the transmembrane protein CD47 to signal regulatory protein-α (SIRPα) on macrophages induces an antiphagocytic signal. Tumor cells hijack this pathway and overexpress CD47 to evade immune destruction. Macrophage antitumor activity can be restored by simultaneously blocking the CD47-SIRPα signaling axis and inducing a prophagocytic signal via tumor-opsonizing antibodies. We identified a novel, fully human mAb (BMS-986351) that binds SIRPα with high affinity. BMS-986351 demonstrated broad binding coverage across SIRPα polymorphisms and potently blocked CD47-SIRPα binding at the CD47 binding site in a dose-dependent manner. In vitro, BMS-986351 increased phagocytic activity against cell lines from solid tumors and hematologic malignancies, and this effect was markedly enhanced when BMS-986351 was combined with the opsonizing antibodies cetuximab and rituximab. A phase I dose-escalation/-expansion study of BMS-986351 for the treatment of advanced solid and hematologic malignancies is underway (NCT03783403).

Significance:

Increasing the phagocytotic capabilities of tumor-associated macrophages by modulating macrophage–tumor cell surface signaling via the CD47-SIRPα axis is a novel strategy. Molecules targeting CD47 have potential but its ubiquitous expression necessitates higher therapeutic doses to overcome potential antigen sink effects. The restricted expression pattern of SIRPα may limit toxicities and lower doses of the SIRPα antibody BMS-986351 may overcome target mediated drug disposition while maintaining the desired pharmacology.
Successful Management of Familial Exudative Vitreoretinopathy with a Large Macular Hole Using Inverted Internal Limiting Membrane Flap Technique
Authors: Akada Masahiro , Nagasawa Toshihiko , Tabuchi Hitoshi
Published: February 2024

Introduction: This case report aims to shed light on a rare presentation of familial exudative vitreoretinopathy (FEVR) co-existing with a large full-thickness macular hole (FTMH) in a 16-year-old male and discuss its successful surgical management, thereby adding to the limited existing knowledge on this topic. Case Presentation: Over an 8-month period, the patient had experienced progressively worsening visual blurring and distortion in his left eye. Following a comprehensive examination, diagnosis confirmed FEVR and an accompanying large FTMH. It was hypothesized that this unusual manifestation resulted from the tractional forces exerted by a thick posterior vitreous membrane and a thin epiretinal membrane – a distinctive attribute of FEVR. The patient underwent surgical intervention, which included pars plana vitrectomy (PPV), internal limiting membrane (ILM) peeling, gas tamponade, and the inverted ILM flap technique. Postoperative outcomes were favorable, with the FTMH successfully closed and substantial improvement observed in the patient’s visual acuity at the 3-month follow-up visit. Conclusion: This case report highlights a rare association of FEVR with FTMH, thereby broadening our understanding of potential complications in patients with FEVR. The successful surgical intervention reinforces the utility of the PPV and the inverted ILM flap technique in managing such complications. It underscores the need for clinicians to maintain vigilance for such atypical manifestations in FEVR patients.
Solid Papillary Carcinoma with Invasion in the Male Breast: A Case Report and Literature Review
Authors: Hoshina Hideko , Kubouchi Kouichi , Takei Hiroyuki
Published: February 2024

Introduction: Solid papillary carcinoma (SPC) accounts for approximately 1% of all breast cancer cases and occurs primarily in postmenopausal women. We report a rare SPC with invasion in the male breast. Case Presentation: A 73-year-old Japanese man presented with bloody nipple discharge and a palpable left breast mass. Mammography revealed a well-defined high-concentration mass. Ultrasonography scans demonstrated an intracystic 10 mm mass under the left nipple without enlarged axillary lymph nodes. A core needle biopsy revealed a ductal carcinoma with nuclear grade 1, which excluded an invasive carcinoma. Magnetic resonance imaging exhibited a 7 mm intense early enhancement in the left breast. A left mastectomy and sentinel lymph node biopsy were performed. The patient was diagnosed with pathological stage IA (T1b N0 M0) breast carcinoma, an invasive pure SPC type without neuroendocrine markers. The patient was treated with oral tamoxifen and survived without any recurrence for 12 months. Conclusion: Invasive SPC of the male breast may occur as a palpable mass or nipple discharge in older men and has a good prognosis.
Survival of a Rhino-Orbital-Cerebral Mucormycosis Patient after Localized Combination Liposomal Amphotericin B Medications: A Case Report
Authors: Zhou Yang
Published: February 2024

Introduction: The aim of this study was to report a case of ROCM related to nasogastric intubation who was survived by liposomal amphotericin B (LAmB) combination therapy in situ without orbital exenteration. Case Presentation: A 44-year-old woman presented with a 1-week history of rapidly enlarging swelling on the right nose, cheek, and lower eyelid after underwent gastrointestinal decompression. The lesions were derived from the nasal area where the nasogastric tube had been placed. Based on the biopsy results and clinical manifestations, ROCM was diagnosed. Immediate combination therapy with intravenous LAmB and micafungin and multisection debridement of the right facial region were applied. Postoperative treatment included cleaning, irrigating, and local dressing of the wound area using LAmB. LAmB was also used daily as binocular eye drops against deep infection on the eyeballs. The patient recovered well 4 months later and remained free of disease after 40 months of follow-up. Conclusion: This case adds to our knowledge on the potential risk of nasogastric intubation for mucormycosis infection. Nasogastric tube may be the source of infection associated with ROCM. This report evaluates the beneficial effect of LAmB combination therapy in situ for cleaning, irrigating, local wound dressing, and eye drops on lesion areas. The combination of LAmB as cleaning, irrigating, local dressing solution, and eye drops to control intraocular and intraorbital ROCM infection has not been previously reported to our knowledge. These methods provide multiple choices to substitute for orbital exenteration on the survival of ROCM patients.
Hemostasis with Metallic Stent for Multiple Metastatic Pancreatic Tumors Complicated with Hemobilia
Authors: Ito Hiroyuki , Omura Yuji , Makuuchi Tomonori , Chou Tsubomi , Ito Ayano , Fujimoto Ryutaro , Yokota Masashi , Tsuda Shingo , Nagata Junko , Hirose Shunji , Yoshii Hisamichi , Izumi Hideki , Sugiyama Tomoko , Tajiri Takuma , Suzuki Takayoshi
Published: February 2024

Introduction: Hemobilia, which refers to bleeding from the bile duct, is rare and difficult to treat. We report a case of successful hemostasis of a pancreatic tumor complicated by hemobilia. Case Presentation: A 76-year-old man was referred to our hospital with a pancreatic head tumor. Endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic ultrasonography-FNA were performed, and the patient was diagnosed with pancreatic metastasis of renal cell carcinoma. After discharge, the patient noted worsening jaundice and progressive anemia and was readmitted. ERCP reveals active bleeding from the duodenal papillae. The patient was placed on a fully covered metallic stent and discharged after confirming hemostasis. Conclusion: Renal cell carcinoma is a tumor with abundant blood flow. If hemobilia occurs, bleeding from pancreatic metastatic tumors should be considered. Additionally, hemostasis using a fully covered metallic stent is useful for treating hemobilia in tumors.
Connected Language Performance in Neurotypical and Persons with Aphasia: Use of the Brazilian-Portuguese Story Retell Procedure
Authors: Ortiz Karin Zazo , Tognin Juliana , de Medeiros Juliana Silveira Ferreira , Fossett Tepanta R.D. , McNeil Malcolm R.
Published: February 2024

Introduction: It is important to analyze the micro- and macrostructure of connected language production across languages in neurotypical and impaired speakers such as people with aphasia (PWA). However, the validity, reliability, sensitivity, or specificity of the available Brazilian-Portuguese connected language production batteries remains untested. Objective: The purpose of this study was to provide a preliminary assessment of the translated Brazilian-Portuguese Story Retell Procedure (SRP-BP) in PWA and neurotypical control participants (NCPs) and investigate whether the SRP can serve as a measure of overall communication impairment in PWA. Methods: This cross-sectional study was developed at the Federal University of São Paulo. Seven right-handed PWA and 14 NCPs were recruited. PWA had a single left-hemisphere post-stroke lesion and were without severe aphasia or non-fluent aphasia that might interfere with performing the SRP. The connected language measures calculated from the SRP-BP were the numbers of words, information units, and propositions produced. The data were analyzed with the non-parametric Mann-Whitney test. Results: The NCPs produced significantly more information units and propositions in each of the 12 SRP-BP stories than the PWA group. The same group results were found for the number of words for 11 of the 12 stories, with no statistically significant difference between groups for the Água (Water) story. Conclusion: The SRP-BP distinguished the connected language production of PWA from that of NCPs. These results motivate additional psychometric assessment and test development of the SRP-BP in neurotypical, PWA, and other language and cognitively impaired populations.
Terapias tópicas para cicatrização de lesão por pressão: identificando a efetividade em pesquisas dos últimos cinco anos
Authors: Vasconcelos Anailda Fontenele , Nascimento Thiago Santos Viana do , Dias Rômulo Soares , Nunes Maria Paula Vieira , Leardini Guilherme Maccagnan , Araújo Glória Stéphany Silva de , Rodrigues Daiane Alexsandra Smaniotto , Macedo Andreia Barcellos Teixeira
Published: February 2024

Objetivo: identificar na literatura científica a efetividade de terapias tópicas para a cicatrização lesão por pressão em adultos. Método: Trata-se de uma revisão integrativa construída em seis etapas, realizada nas bases de dados BVS, SCIELO, PUBMED e Google Acadêmico. Os descritores foram “Lesão por pressão” e “Cicatrização” separados pelo operador booleano AND. Foram incluídos ensaios clínicos publicados de 2018 a fevereiro de 2023, e excluídos artigos duplicados ou que não estivessem disponíveis na íntegra. Para a extração foi construído um quadro sinóptico e os dados foram analisados de forma descritiva. Resultados: A identificação resultou em 424 artigos e a amostra final em 17 produções científicas, sendo 16(94,1%) em inglês. As terapias testadas nos últimos cinco anos foram medicações e extratos naturais tópicas, derivados sanguíneos, estímulo elétrico, gelatina e terapia a laser de baixa intensidade. Identificou-se efetividade em 16 (94,1%) dos tratamentos propostos nas publicações selecionadas. Conclusão: Identifica-se que terapias combinadas, além do curativo convencional, aceleram o processo de cicatrização das LP, podendo contribuir para redução de lesões crônicas e trazer melhorias na qualidade de vida dos pacientes acometidos.
A Revolução de Jasmin entre rupturas e continuidades
Authors: Spina Larissa Docal , Takeuti Shiro
Published: February 2024

This paper aims at reecting on processes of rupture and continuity considering the Jasmine Revolution – the Tunisian movements of the Arab Spring between 2010 and 2011. We analyzed the relationship between Mohamed Bouazizi’s self-immolation after conicts with the Tunisian guard and his image, followed by a section of narratives presented by the British newspaper The Guardian.We regard this episode’s representations and its eects on the Western media, while taking into account the East/West relations. Finally, a deeper investigation of the socio-political context was carried out in order to think about the colonial context, the colonizer and colonized identity constructions and the limits they place on changes. The studies carried out here point to ruptures in the symbolic sphere, such as the change of the political regime, and continuities in the economic eld, given Tunisia’s dependence on foreign investments and the continuity of poverty and unemployment of the Tunisian population.