bluuebunny/crossref_metadata_2025 huggingface dataset:
Audience-metric continuity? Approaching the meaning of measurement in the digital everyday
Authors: Bolin Göran , Velkova Julia
Published: March 2020

This article argues for an expansion of existing studies on the meaning of metrics in digital environments by evaluating a methodology tested in a pilot study to analyse audience responses to metrics of social media profiles. The pilot study used the software tool Facebook Demetricator by artist Ben Grosser in combination with follow-up interviews. In line with Grosser’s intentions, the software indeed provoked reflection among the users. In this article, we reflect on three kinds of disorientations that users expressed, linked to temporality, sociality and value. Relating these to the history of audience measurement in mass media, we argue that there is merit in using this methodology for further analysis of continuities in audience responses to metrics, in order to better understand the ways in which metrics work to create the ‘audience commodity’.
Regimes of temporality: China, Tibet and the politics of time in the post-2008 era
Authors: Kehoe Séagh
Published: March 2020

While the politics of time are an important dimension of Chinese state discourse about Tibet, it remains insufficiently explored in theoretical and practical terms. This article examines the written and visual discourses of Tibetan temporality across Chinese state media in the post-2008 era. It analyses how these media discourses attempt to construct a ‘regime of temporality’ in order to manage public opinion about Tibet and consolidate Chinese rule over the region. While the expansion of online technologies has allowed the state to consolidate its discourses about Tibet’s place within the People’s Republic of China (PRC), they have also provided Tibetans a limited but valuable space to challenge these official representations through counter readings of Tibet’s past, present and future. In doing so, this article contributes new insights on the production of state power over Tibet, online media practices in China, and the disruptive potential of social media as sites of Tibetan counter discourses.
A linear model for the machine tool assembly error prediction considering roller guide error and gravity-induced deformation
Authors: He Gaiyun , Shi Panpan , Guo Longzhen , Ding Bohui
Published: March 2020

In assembly, error prediction and control according to the error state of the machine parts are the key links to ensuring the accuracy of the entire machine tool. In this study, an assembly error modeling method considering the error of the roller guide and gravity-induced deformation is proposed. First, based on the Hertz contact theory, a nonlinear error propagation model for the roller guide to the moving part is proposed. With this model, the analytical relationship between the straightness error of the guide rail and the errors of the moving part can be established. Then, after the linearization of the guide error model, a machine assembly error model considering the guide error is proposed. This model expresses the linear relationship between the error of the rolling joint surface and the error of the machine tool after the final assembly. Additionally, considering the influence of gravity deformation of structural parts, the gravity deformation is extracted by the finite element analysis method and added to the model by linear superposition. As a result, the model corresponds more with the practical assembly process. Finally, an assembly error prediction method of the precision horizontal machining center is presented, and a case is studied to demonstrate the validity of the proposed model and method.
Optimal path generation in scala tympani and path planning for robotic cochlear implant of perimodiolar electrode
Authors: Wang Zuo , Li Jianjun , Wu Yongzhen , Zhu Ruifeng , Wang Binrui , Zhao Kai
Published: March 2020

In this study, a new idea of the optimal path generation method was proposed and a path planning strategy for robotic cochlear implant of perimodiolar electrode was designed. The centerline of scala tympani channel was taken as the optimal implant path of the perimodiolar electrode, which aimed to reduce the damage of the electrode to the cochlea during implantation. First, the three-dimensional cochlear model was reconstructed based on the micro-computed tomography images of cochlea, and it was re-segmented to obtain the cross sections of the scala tympani at different angles. Then, the image processing method was used to determine the central point of the scala tympani cross sections. The cubic B-spline interpolation method was used to fit these discrete central points to generate the optimal path. Finally, the coordinate information of the optimal path was combined with the stylet extraction state of perimodiolar electrode to conduct the path planning for robotic cochlear implant, and the result was sent to the robot for kinematic inverse solution to obtain the robot motion trajectory. The robotic cochlear implant experiment was performed with the model of scala tympani. The results showed that the maximum implant force based on path planning was 0.084 N, and the maximum implant force without path planning was 0.134 N. The optimal path generation and the path planning method effectively help to reduce the damage of the electrode to the cochlea.
Comprehensive analysis on orthopedic drilling: A state-of-the-art review
Authors: Jamil Muhammad , Rafique Saima , Khan Aqib Mashood , Hegab Hussien , Mia Mozammel , Gupta Munish Kumar , Song Qinghua
Published: March 2020

Bone drilling is a well-known internal fixation procedure to drill a hole, fixing the bone fragments to reduce the susceptibility of permanent paralysis. The success of bone drilling is evaluated based on the extent of osteonecrosis in terms of heat generation, tissue damage, quality of hole, and drilling forces. The appropriate control of cutting conditions, drill geometric parameters, and bone-specific parameters offer bone drilling a viable solution through conventional and non-conventional drilling techniques. The majority of the published research work considers only limited parameters and tries to optimize the drilling parameters and performance measures. However, bone drilling involves numerous conventional and non-conventional drilling parameters and technologies. In order to develop a better understanding of all the studied parameters and performance measures, there is a dire need to develop a framework. The key objective of this review study is to establish a hierarchy of the framework by collecting almost all the parameters studied until now and addressed the relationship between parameters and performance measures to diminish the controversies in the published literature. Therefore, this framework is novel in nature, organizing all the parameters, performance measures, logical comparisons, and limitations of studies. This holistic review can help medical surgeons and design engineers to understand the complicated relationship among parameters and performance measures associated with this state-of-art technologies. Also, modeling, simulations, and optimization techniques are included to explore the application of such techniques in recent advancements in orthopedic drilling.
Prevalence and risk factors of strongyloidiasis in patients with systemic lupus erythematosus in Southern Thailand
Authors: Juthong Siriporn , Geater Alan F. , Dekumyoy Paron , Hortiwakul Thanaporn , Siripaitoon Boonjing , Aiewruengsurat Duangkamol , Thongbun Nannapas
Published: March 2020

Background

Strongyloidiasis can be fatal in systemic lupus erythematosus (SLE) patients, but few epidemiological studies have investigated the burden of this tropical disease among the SLE population. This study aimed to assess the prevalence and associated factors of strongyloidiasis among SLE patients in Southern Thailand.

Methods

A cross-sectional study was conducted on 180 SLE patients attending the Rheumatology Clinic at Songklanagarind Hospital. Stool specimens were collected and examined using the direct smear technique and agar plate culture technique. Serum anti- Strongyloides stercoralis IgG was measured by IgG-ELISA.

Results

The overall prevalence of strongyloidiasis by combined parasitologyl and/or serology was 15.6%. The prevalence of strongyloidiasis by parasitological methods was 2.2%. Positive parasitology and/or serology was associated with male sex and a SLE disease duration of less than two years.

Conclusion

Strongyloidiasis is highly prevalent among the SLE population. A combination of serological and parasitological methods increases the rate of diagnosis of strongyloidiasis in SLE patients.
Decision-Making Competence: More Than Intelligence?
Authors: Bruine de Bruin Wändi , Parker Andrew M. , Fischhoff Baruch
Published: March 2020

Decision-making competence refers to the ability to make better decisions, as defined by decision-making principles posited by models of rational choice. Historically, psychological research on decision-making has examined how well people follow these principles under carefully manipulated experimental conditions. When individual differences received attention, researchers often assumed that individuals with higher fluid intelligence would perform better. Here, we describe the development and validation of individual-differences measures of decision-making competence. Emerging findings suggest that decision-making competence may tap not only into fluid intelligence but also into motivation, emotion regulation, and experience (or crystallized intelligence). Although fluid intelligence tends to decline with age, older adults may be able to maintain decision-making competence by leveraging age-related improvements in these other skills. We discuss implications for interventions and future research.
Using Social Ecological Theory to Identify Factors Associated With Risky Sexual Behavior in Cambodian Adolescent Girls and Young Women Aged 10 to 24 Years: A Systematic Review
Authors: Rizvi Farwa , Williams Joanne , Maheen Humaira , Hoban Elizabeth
Published: March 2020

There is an increase in risky sexual behavior (RSB) in Cambodian female youth aged 10 to 24 years, which can contribute to detrimental sexual and reproductive health due to the increased risk of acquiring sexually transmitted infections, unintended pregnancies, or abortions. Bronfenbrenner’s social ecological model was used to identify factors at personal, microenvironment, and macroenvironment levels potentially associated with RSB. A systematic literature review employing PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines was conducted to search 8 databases for articles published between 1994 and 2019. A risk of bias tool was applied for methodological quality of the 4 included studies. RSB is associated with multiple factors including sexual debut at young age, alcohol and substance abuse, multiple partners, living away from parents or orphan status, peer delinquency, non-use of condoms by partners, transactional sex, low education and socioeconomic status, and no access to sexual and reproductive health services. Multipronged preventive strategies operating at different levels are recommended in terms of including sex education and increasing reproductive health literacy programs at the schools and community programs for safe sex, condom use and sexual negotiation skills, and access to modern contraceptive methods.
Childhood Domestic Violence as an Ancestor for Adulthood Mental Health Problems: Experiences of Jordanian Women
Authors: Al-Modallal Hanan , Al-Omari Hasan , Hamaideh Shaher , Shehab Tariq
Published: March 2020

This study was conducted to explore the relationship between women’s history of experiencing different types of abuse during childhood and development of mental health problems in adulthood. A convenience sample of 409 women recruited from health care centers in Jordan provided data for the study. One-way between-groups multivariate analysis of variance was implemented. Results indicated absence of statistically significant differences in mental health problems between physically abused and sexually abused women compared to their counterparts. Further, a statistically significant difference in mental health was found between women who experienced emotional abuse and childhood neglect compared to their counterparts (Wilks’ lambda for emotional abuse = .914, p < .0001; Wilks’ lambda for childhood neglect = .83, p < .0001). Between-groups comparisons using Bonferroni adjustment indicated that all dependent variables (depression, anxiety, stress, and self-esteem) differed significantly between emotionally and nonemotionally abused women and between neglected and nonneglected women. It was concluded that not all childhood abuse experiences lead to long-term impacts on women’s mental health. However, mental health consequences of childhood abuse may alter women’s obligations toward family, children, and home. Therefore, efforts directed toward assessing women’s history of childhood abuse are very important especially for those who are starting a marital relationship.
A preliminary comparison of the Aravind aurolab drainage implant with the Baerveldt glaucoma implant: A matched case-control study
Authors: Hafeezullah Najla , AlHilali Sara , Alghulaydhawi Fahad , Edward Deepak P , Ahmad Sameer , Malik Rizwan
Published: March 2020

Purpose:

The Aurolab® aqueous drainage implant is a low-cost alternative to the Baerveldt glaucoma implant. The aim of this study was to test the hypothesis that the two implants are comparable in terms of surgical success and safety.

Methods:

We conducted a retrospective case-control study of Aurolab aqueous drainage implant done at our institution from May 2015 and May 2017. Twenty-five consecutive patients who received an Aurolab aqueous drainage implant were matched by age and diagnosis to patients who received a Baerveldt glaucoma implant. Data were collected pre-operative and post-operative visits, including visual acuity and intraocular pressure, number of medications, and complications. Surgical success was defined as intraocular pressure between 5 and 21 mmHg with a minimum 20% reduction from baseline, without loss of light perception or the need for further glaucoma surgery. Cox regression analysis was used to predict factors associated with surgical success.

Results:

The median (interquartile range, IQR) intraocular pressure at 1 year was 16.0 (8.0) mmHg for the Baerveldt glaucoma implant and 13.0 (8.0) mmHg for the Aurolab aqueous drainage implant, p = 0.38. Success (mean ± SE) at 1 year for the intraocular pressure >21-mmHg failure criterion was 65% ± 15% for the Baerveldt glaucoma implant and 79% ± 11% for the Aurolab aqueous drainage implant (p = 0.80). The frequency of complications listed was similar for the two groups (Fisher’s exact p = 0.71). In the Cox regression, the type of implant was not found to be associated with surgical success.

Conclusions:

Our preliminary results suggest that the Aurolab aqueous drainage implant is comparable to the Baerveldt glaucoma implant. Further long-term data in a larger population are needed to confirm these findings.
Distal femoral cortical hypertrophy not associated with thigh pain using a short stem femoral implant
Authors: Crawford David A , Adams Joanne B , Morris Michael J , Berend Keith R , Lombardi Adolph V
Published: March 2020

Background:

Thigh pain following a well-fixed total hip arthroplasty (THA) remains problematic and a source of patient dissatisfaction. The purpose of this study is to evaluate if the development of distal femoral cortical hypertrophy (DFCH) is associated with postoperative thigh pain after THA.

Methods:

All patients who underwent an uncomplicated primary THA via a direct anterior approach with the Taperloc Microplasty (Zimmer Biomet, Warsaw, IN, USA) implant between 2011 and 2015 were mailed a pain drawing questionnaire. Radiographs were reviewed at 1 year minimum to determine cortical thickness change from immediate post-op. Thigh pain was compared to DFCH. 293 patients were included in the study.

Results:

Mean follow-up was 3.2 years. A total of 218 hips (74%) had cortical hypertrophy in Gruen zone 3 and 165 hips (56%) had cortical hypertrophy in Gruen zone 5. 52 hips (18%) had ⩾25% cortical hypertrophy in zone 3 and 91 hips (31%) had ⩾25% cortical hypertrophy in zone 5. A total of 44 patients (15%) reported anterior thigh pain and 43 patients (15%) reported lateral thigh pain. Development of DFCH in either Gruen zone 3 or 5 was not associated with anterior or lateral thigh pain. Stem size was positively correlated with zone 3 hypertrophy and inversely related to zone 5 hypertrophy. Thigh pain was not associated with patient age, gender, activity level or stem size.

Conclusions:

The development of distal femoral cortical hypertrophy after THA with a short stem implant was high, but not associated with patient-reported anterior or lateral thigh pain.
Screening a chemically defined extracellular matrix mimetic substrate library to identify substrates that enhance substrate-mediated transfection
Authors: Hamann Andrew , Thomas Alvin K , Kozisek Tyler , Farris Eric , Lück Steffen , Zhang Yixin , Pannier Angela K
Published: March 2020

Nonviral gene delivery, though limited by inefficiency, has extensive utility in cell therapy, tissue engineering, and diagnostics. Substrate-mediated gene delivery (SMD) increases efficiency and allows transfection at a cell-biomaterial interface, by immobilizing and concentrating nucleic acid complexes on a surface. Efficient SMD generally requires substrates to be coated with serum or other protein coatings to mediate nucleic acid complex immobilization, as well as cell adhesion and growth; however, this strategy limits reproducibility and may be difficult to translate for clinical applications. As an alternative, we screened a chemically defined combinatorial library of 20 different extracellular matrix mimetic substrates containing combinations of (1) different sulfated polysaccharides that are essential extracellular matrix glycosaminoglycans (GAGs), with (2) mimetic peptides derived from adhesion proteins, growth factors, and cell-penetrating domains, for use as SMD coatings. We identified optimal substrates for DNA lipoplex and polyplex SMD transfection of fibroblasts and human mesenchymal stem cells. Optimal extracellular matrix mimetic substrates varied between cell type, donor source, and transfection reagent, but typically contained Heparin GAG and an adhesion peptide. Multiple substrates significantly increased transgene expression (i.e. 2- to 20-fold) over standard protein coatings. Considering previous research of similar ligands, we hypothesize extracellular matrix mimetic substrates modulate cell adhesion, proliferation, and survival, as well as plasmid internalization and trafficking. Our results demonstrate the utility of screening combinatorial extracellular matrix mimetic substrates for optimal SMD transfection towards application- and patient-specific technologies.

Impact statement

Substrate-mediated gene delivery (SMD) approaches have potential for modification of cells in applications where a cell-material interface exists. Conventional SMD uses ill-defined serum or protein coatings to facilitate immobilization of nucleic acid complexes, cell attachment, and subsequent transfection, which limits reproducibility and clinical utility. As an alternative, we screened a defined library of extracellular matrix mimetic substrates containing combinations of different glycosaminoglycans and bioactive peptides to identify optimal substrates for SMD transfection of fibroblasts and human mesenchymal stem cells. This strategy could be utilized to develop substrates for specific SMD applications in which variability exists between different cell types and patient samples.
Suppression of HDAC by sodium acetate rectifies cardiac metabolic disturbance in streptozotocin–nicotinamide-induced diabetic rats
Authors: Olaniyi Kehinde S , Amusa Oluwatobi A , Areola Emmanuel D , Olatunji Lawrence A
Published: March 2020

Diabetes mellitus, particularly type 2 occurs at global epidemic proportions and leads to cardiovascular diseases. Molecular studies suggest the involvement of epigenetic alterations such as histone code modification in the progression of cardiometabolic disorders. However, short chain fatty acids (SCFAs) are recognized as epigenetic modulators by their histone deacetylase inhibitory property. It is therefore hypothesized that cardiac histone deacetylase activity increases in type II diabetes and SCFA, acetate, would inhibit histone deacetylase with accompanying restoration of glucose dysregulation, cardiac lipid deposition, and tissue damage in male Wistar rats. Twenty-four male rats (240–270 g) were allotted into four groups ( n = 6 per group) namely: vehicle-treated ( p.o.), sodium acetate-treated (200 mg/kg), diabetic, and diabetic+sodium acetate-treated groups. Diabetes was induced by intraperitoneal injection of streptozotocin 65 mg/kg after a dose of nicotinamide 110 mg/kg. The results showed that diabetic rats had, glucose dysregulation, elevated serum and cardiac triglyceride, malondialdehyde, alanine aminotransferase, histone deacetylase, serum aspartate transaminase, cardiac low density lipoprotein cholesterol (LDLc), glutathione/glutathione disulphide ratio (GSH/GSSG), reduced serum and cardiac high density lipoprotein cholesterol (HDLc), and serum GSH/GSSG. Histological analysis revealed disrupted cardiac fiber in diabetic rats. However, sodium acetate attenuated glucose dysregulation and improved serum and cardiac GSH/GSSG. Sodium acetate normalized cardiac triglyceride accumulation, malondialdehyde, serum aspartate transaminase levels and prevented cardiac tissue damage in diabetic rats. These effects were associated with suppressed histone deacetylase activity. Therefore, sodium acetate attenuated but failed to normalize glucoregulation. Nevertheless, it ameliorated oxidative stress- and lipid dysmetabolism-driven cardiovascular complications in diabetic rats by the suppression of histone deacetylase activity.

Impact statement

This study provides evidence that STZ-NA-induced diabetes mellitus is associated with cardiac triglyceride accumulation and tissue disruption with corresponding increase in cardiac HDAC activity. However, sodium acetate suppresses cardiac HDAC activity and normalizes cardiac triglyceride and tissue integrity in diabetic rats. Therefore, the study suggests that sodium acetate is beneficial for cardioprotection in diabetes mellitus.
Detection of ship targets in photoelectric images based on an improved recurrent attention convolutional neural network
Authors: Xu Zhijing , Huo Yuhao , Liu Kun , Liu Sidong
Published: March 2020

Deep learning algorithms have been increasingly used in ship image detection and classification. To improve the ship detection and classification in photoelectric images, an improved recurrent attention convolutional neural network is proposed. The proposed network has a multi-scale architecture and consists of three cascading sub-networks, each with a VGG19 network for image feature extraction and an attention proposal network for locating feature area. A scale-dependent pooling algorithm is designed to select an appropriate convolution in the VGG19 network for classification, and a multi-feature mechanism is introduced in attention proposal network to describe the feature regions. The VGG19 and attention proposal network are cross-trained to accelerate convergence and to improve detection accuracy. The proposed method is trained and validated on a self-built ship database and effectively improve the detection accuracy to 86.7% outperforming the baseline VGG19 and recurrent attention convolutional neural network methods.
An unusual case of remitting seronegative symmetrical synovitis with pitting edema: Case report and literature review
Authors: Joseph Anne DD , Kumanan Thirunavukarasu , Aravinthan Naarani , Suganthan Navaneethakrishnan
Published: March 2020

Remitting seronegative symmetrical synovitis with pitting edema is a rare but well-recognized clinical entity that is easily overlooked due to lack of clinical vigilance. It is classically described as an acute onset of symmetrical tenosynovitis of both upper and lower extremities with pitting edema, mostly noted in elderly population. Young patients with other rheumatological diseases and unilateral involvement had also been reported, but symmetrical remitting seronegative symmetrical synovitis with pitting edema in a young patient is a rare observation. We hereby report a case of a remitting seronegative symmetrical synovitis with pitting edema in a young male affected by no rheumatological diseases in the past, typically fulfilling the diagnostic criteria and well responded to low-dose steroid therapy. The salient features of the present case in terms of age, remitting seronegative symmetrical synovitis with pitting edema possibly related to undifferentiated arthropathy, reactive arthritis, or diabetes mellitus.
Lumbar Decompression and Interbody Fusion Improves Gait Performance, Pain, and Psychosocial Factors of Patients With Degenerative Lumbar Spondylolisthesis
Authors: Haddas Ram , Sandu Cezar D. , Mar Damon , Block Andrew , Lieberman Isador
Published: March 2020

Study Design:

Prospective cohort study.

Objective:

Evaluate changes in gait, pain, and psychosocial factors among degenerative lumbar spondylolisthesis (DLS) patients before and 3 months after surgical intervention.

Methods:

Forty-four symptomatic DLS patients performed clinical gait analysis 1 week before surgery and 3 months after surgery. Patients performed a series of over-ground gait trials at a self-selected speed. Twenty-two matched asymptomatic controls underwent the same battery of tests. Three-dimensional motion tracking was used to analyze gait kinematics. Patient-reported outcomes, gait range of motion, and spatiotemporal parameters compared before and after lumbar decompression with fusion.

Results:

Surgical intervention resulted in significant improvements in walking speed ( P = .021), stride time ( P = .020), step time ( P = .014), and single-support time ( P = .038). Significant improvements in joint range-of-motion were found for knee ( P = .002) and hip flexion ( P = .006). Degenerative lumbar spondylolisthesis patients reported significant reductions in pain, disability, and improved psychological perceptions for fear-avoidance of pain and motion (all P < .001).

Conclusions:

Surgical treatment of DLS resulted in a faster, more efficient gait in addition to significant reductions in pain, disability, and psychological fear associated with pain and motion. These beneficial changes that we identified early in the postoperative period indicate that patients return to the quality of life they seek early on. Clinical gait analysis provides objective, quantifiable measures of gait parameters that provide new insight into both the preoperative disability associated with DLS and into the early postoperative function of patients during their rehabilitation.
The Community Union model of organizing in Rio Grande Valley colonias
Authors: Rivera Danielle Z
Published: March 2020

In theorizing community organizing, Saul Alinsky’s model still forms the dominant narrative in the United States. Yet, countless communities do not map neatly onto this model. In particular, there is growing recognition of César Chávez’s organizing in South Texas and, additionally, how this work differs from Chávez’s more well-known organizing in California. In the 1960s, Chávez created the Community Union model, which forms the basis of contemporary organizing in much of the region’s colonias, extralegal communities within 150 miles of the United States/Mexico border that suffer from a dearth of basic services and infrastructures. By providing these basic services and political support, the Community Union model has become the dominant mode of organizing and engagement in South Texas colonias. Through an insurgent historiography provided by colonia organizers in the Rio Grande Valley of South Texas, a counternarrative of colonia organizing shows the past, present, and potential future of the Community Union model in South Texas colonias. This counter narrative was composed through archival research on the United Farmworkers and open-ended interviews with colonia organizers conducted between 2014 and 2017. Ultimately, this analysis of the Community Union model suggests that Latinx organizing may be marginalized in organizing literature due to their “everyday” characteristics: slow movements, non-direct actions, and (re)questioning of priorities. From this, the role of organizing theories from organizers on-the-ground becomes central: we cannot assume organizers everywhere operate under universally applied theories. As such, it is important to see organizers as dynamic and context-specific in their motivations and guiding theories.
Co-curing behaviour of thermoset composites with a thermoplastic boundary layer for welding purposes
Authors: Brauner Christian , Nakouzi Sawsane , Zweifel Lucian , Tresch Jens
Published: March 2020

The primary objective of this study is to determine the interphase behaviour of a thermoset epoxy resin that is commercially used for carbon fibre–reinforced composite materials in aerospace structures and a suitable thermoplastic material that can be used as a boundary layer. The thermoplastic boundary layer will be used for welding purposes to join structural components with a fraction of the effort compared to conventional gluing processes. In this study, the interphase formation of an epoxy resin with several thermoplastic materials, namely, polyetheretherketone, polyvinylidenfluoride, polyphenylensulfide and polyetherimide (PEI), is studied via hot-stage microscope experiments. Based on this study, PEI was selected, and a detailed study was performed to determine the dependency of dissolution, diffusion and phase separation mechanisms under various isothermal conditions. Additionally, the welding behaviour was investigated by a resistance welding rig whereby the process parameters were statistically varied to optimize the lap shear strength. The results of this study will enable a statement about the interphase development, the morphology and the mechanical properties which is a key element of fully understanding the process.
Commentary on “Constraints on the Equations of State of stiff anisotropic minerals: rutile, and the implications for rutile elastic barometry” [Miner. Mag. 83 (2019) pp. 339–347]
Authors: Angel Ross J. , Alvaro Matteo , Schmid-Beurmann Peter , Kroll Herbert
Published: March 2020

The conclusion of Zaffiroet al.(2019; Constraints on the Equations of State of stiff anisotropic minerals: rutile, and the implications for rutile elastic barometry.Mineralogical Magazine,83, 339–347) that the Mie–Grüneisen–Debye (MGD) Equation of State (EoS) cannot fit the available data for rutile is shown to be incorrect, even though rutile exhibits significant anisotropic thermal pressure which invalidates the quasi-harmonic approximation used as the basis for the MGD EoS. The refined parameters for the MGD EoS of rutile are:KTR0= 205.05(25) GPa,$K_{TR0}^{\prime} $= 7.2(5), θD= 399(20) K, γ0= 1.40(2) andq= 1.5(7). This EoS predicts volumes, bulk moduli and volume thermal expansion coefficients for rutile at metamorphic conditions that are statistically indistinguishable from those predicted by the ‘isothermal’ type of EoS reported previously.
Diagnosis of chronic thromboembolic pulmonary hypertension after acute pulmonary embolism
Authors: Klok Fredrikus A. , Couturaud Francis , Delcroix Marion , Humbert Marc
Published: March 2020

Chronic thromboembolic pulmonary hypertension (CTEPH) is the most severe long-term complication of acute pulmonary embolism (PE). Untreated CTEPH is fatal, but, if diagnosed in time, successful surgical (pulmonary endarterectomy), medical (pulmonary hypertension drugs) and/or interventional (balloon pulmonary angioplasty) therapies have been shown to improve clinical outcomes, especially in case of successful pulmonary endarterectomy. Early diagnosis has however been demonstrated to be challenging. Poor awareness of the disease by patients and physicians, high prevalence of the post-PE syndrome (i.e.persistent dyspnoea, functional limitations and/or decreased quality of life following an acute PE diagnosis), lack of clear guideline recommendations as well as inefficient application of diagnostic tests in clinical practice lead to a reported staggering diagnostic delay >1 year. Hence, there is a great need to improve current clinical practice and diagnose CTEPH earlier. In this review, we will focus on the clinical presentation of and risk factors for CTEPH, and provide best practices for PE follow-up programmes from expert centres, based on a clinical case.
Association between physical activity and risk of hospitalisation in bronchiectasis
Authors: Alcaraz-Serrano Victoria , Gimeno-Santos Elena , Scioscia Giulia , Gabarrús Albert , Navarro Adria , Herrero-Cortina Beatriz , Amaro Rosanel , Fernández-Barat Laia , Torres Antoni
Published: March 2020

Background

Patients with bronchiectasis have a less active lifestyle than healthy peers, but the association with hospital admission has not been explored. The aim of this study was to investigate the association between 1) any physical activity variable; and 2) sedentary time, with hospitalisation due to exacerbation in adults with bronchiectasis.

Methods

In this prospective observational study, baseline lung function, quality of life, exercise tolerance, severity of bronchiectasis and physical activity were recorded. Physical activity was objectively assessed over a week using a SenseWear armband and the results were expressed in steps·day–1and sedentary time. Number of hospitalisations due to a bronchiectasis exacerbation and time to first event were recorded after 1-year follow-up.

Results

Sixty-four patients with bronchiectasis were analysed, of whom 15 (23%) were hospitalised during the follow-up. Hospitalised patients showed poor baseline clinical and severity outcomes, fewer steps walked per day and more sedentary behaviour than the non-hospitalised group. Patients who walked ≤6290 steps·day–1or spent ≥7.8 h·day–1in sedentary behaviour had an increased risk of hospital admission due to bronchiectasis exacerbation at 1-year follow-up. Specifically, ≥7.8 h·day–1of sedentary behaviour was associated with a 5.9-fold higher risk of hospital admission in the following year.

Conclusions

Low levels of physical activity and high sedentary time at baseline were associated with a higher risk of hospitalisation due to bronchiectasis exacerbation. If these findings are validated in future studies, it might be appropriate to include physical activity and sedentary behaviour as an item in severity scores.
Overdiagnosis of lung cancer with low-dose computed tomography screening: meta-analysis of the randomised clinical trials
Authors: Brodersen John , Voss Theis , Martiny Frederik , Siersma Volkert , Barratt Alexandra , Heleno Bruno
Published: March 2020

In low-dose computed tomography (LDCT) screening for lung cancer, all three main conditions for overdiagnosis in cancer screening are present: 1) a reservoir of slowly or nongrowing lung cancer exists; 2) LDCT is a high-resolution imaging technology with the potential to identify this reservoir; and 3) eligible screening participants have a high risk of dying from causes other than lung cancer. The degree of overdiagnosis in cancer screening is most validly estimated in high-quality randomised controlled trials (RCTs), with enough follow-up time after the end of screening to avoid lead-time bias and without contamination of the control group.

Nine RCTs investigating LDCT screening were identified. Two RCTs were excluded because lung cancer incidence after the end of screening was not published. Two other RCTs using active comparators were also excluded. Therefore, five RCTs were included: two trials were at low risk of bias, two of some concern and one at high risk of bias. In a meta-analysis of the two low risk of bias RCTs including 8156 healthy current or former smokers, 49% of the screen-detected cancers were overdiagnosed. There is uncertainty about this substantial degree of overdiagnosis due to unexplained heterogeneity and low precision of the summed estimate across the two trials.

Key points

Nine randomised controlled trials (RCTs) on low-dose computed tomography screening were identified; five were included for meta-analysis but only two of those were at low risk of bias.

In a meta-analysis of recent low risk of bias RCTs including 8156 healthy current or former smokers from developed countries, we found that 49% of the screen-detected cancers may be overdiagnosed.

There is uncertainty about the degree of overdiagnosis in lung cancer screening due to unexplained heterogeneity and low precision of the point estimate.

If only high-quality RCTs are included in the meta-analysis, the degree of overdiagnosis is substantial.

Educational aims

To appreciate that low-dose computed tomography screening for lung cancer meets all three main conditions for overdiagnosis in cancer screening: a reservoir of indolent cancers exists in the population; the screening test is able to “tap” this reservoir by detecting biologically indolent cancers as well as biologically important cancers; and the population being screened is characterised by a relatively high competing risk of death from other causes

To learn about biases that might affect the estimates of overdiagnosis in randomised controlled trials in cancer screening
LncRNA HULC induces the progression of osteosarcoma by regulating the miR-372-3p/HMGB1 signalling axis
Authors: Li Yong , Liu Jing-Jing , Zhou Jia-Hui , Chen Rui , Cen Chao-Qun
Published: March 2020

Background

Osteosarcoma is a malignancy that normally affects children, adolescents, and young adults. Although accumulating evidence has demonstrated the importance of HULC in osteosarcoma, little is reported about its functional roles and molecular mechanisms.

Methods

The expression of HULC and miR-372-3p in osteosarcoma tissues was quantified by qRT-PCR. The regulatory roles of HULC and miR-372-3p on cell proliferation, apoptosis, migration and invasion were determined by CCK-8, colony formation, flow cytometry, wound healing, and transwell assays, respectively. The bioinformatics prediction software RAID v2.0 was used to predict the putative binding sites. The interactions among HULC, miR-372-3p and HMGB1 were explored by luciferase assay and western blot assay.

Results

Our results revealed elevated HULC and decreased miR-372-3p expression in both osteosarcoma tissues and cell lines. Overexpression of HULC or knockdown of miR-372-3p promoted osteosarcoma cell proliferation, migration and invasion and induced cell apoptosis. Bioinformatics and luciferase assays verified that HULC directly interacted with miR-372-3p to attenuate miR-372-3p binding to the HMGB1 3′-UTR. Furthermore, mechanistic investigations confirmed that activation of the miR-372-3p/HMGB1 regulatory loop by knockdown of miR-372-3p or overexpression of HMGB1 reversed the in vitro roles of HULC in promoting osteosarcoma cell proliferation, migration and invasion.

Conclusion

Our study is the first to demonstrate that HULC may act as a ceRNA to modulate HMGB1 expression by competitively sponging miR-372-3p, leading to the regulation of osteosarcoma progression, which provides new insight into osteosarcoma diagnosis and treatment.
The cerebellum is associated with 2-year prognosis in patients with high-frequency migraine
Authors: Liu Hung-Yu , Lee Pei-Lin , Chou Kun-Hsien , Lai Kuan-Lin , Wang Yen-Feng , Chen Shih-Pin , Chen Wei-Ta , Wang Shuu-Jiun
Published: March 2020

Background

The increase of headache frequency is associated with higher headache related disability and lower quality of life in patients with migraine. However, the pathophysiology of migraine progression, persistence, or remission is elusive. The purpose of this study is to identify the brain signatures that are predictive of the long-term outcomes among patients with high-frequency migraine (HFM: 10–30 headache days/month).

Methods

We prospectively enrolled patients with HFM and healthy controls and collected their baseline clinical profiles and brain-MRI data at first visit. We longitudinally followed the patients and determined their outcomes at 2-year follow-up. Good outcome was defined as ≥50% reduction of baseline headache days and poor outcome was defined as reduction < 50% or frequency increase. Voxel-based morphometry was used to study gray matter volume (GMV), and structural covariance was used to investigate structural connectivity.

Results

Among 56 patients with HFM, 37 had good outcome and 19 poor outcome. Compared to the healthy controls (n = 37), patients with poor outcome had decreased GMV over the left posterior cingulate gyrus, and increased GMV over the bilateral cerebellum and the right precentral gyrus. Further, patients with poor outcome had greater GMV over the right and the left cerebella compared to patients with good outcome, and the GMVs of the cerebella were correlated to 2-year headache frequencies (right: r = 0.38, P = 0.005; left: r = 0.35, P = 0.009). Structural connectivity were increased between the cerebellum and the cuneus, the calcarine cortex, and the temporal lobe, respectively, in patients with poor outcome, and was decreased between the cerebellum and the prefrontal cortex in patients with poor outcome. The structural covariance integrities between the right cerebellum and the right cuneus were correlated to 2-year headache frequencies (r = 0.36, P = 0.008).

Conclusions

Structural volume and connectivity changes of the cerebellum may underlie headache persistence in patients with HFM.
Application of cook balloon during aorta replacement in a pregnant Marfan-syndrome patient: a case report
Authors: Zhang Lu , Yan Bin , Cui Xue , Liu Jinghong , Shi Fangxin
Published: March 2020

Background

Aortic dissection is a rare and emergent condition. Aortic dissection during pregnancy is not much known but it is quite lethal to both mother and infant. Earlier reports published show that clinicians conducted hysterectomies during cesarean section to avoid anticoagulant-induced uterine bleeding during the following aortic surgery.

Case presentation

A woman (38, gravida 1, para 0) in the 37th gestational week suffered an acute, severe, sharp pain in the chest and back. She was diagnosed with Standford type A aortic dissection and suspected with Marfan syndrome. An emergency cesarean section was performed immediately to deliver the baby. Since the patient was on anticoagulants during aortic replacement, so Cook balloon was inserted into the uterus to prevent postpartum hemorrhage. This helped to maintain the uterus intact. Family genetic testing showed that the patient was a carrier of FBN1 mutation which was inherited from the patient’s mother, and the newborn also carried the mutation. Hence the patient was concluded to be positive for Marfan syndrome.

Conclusion

It is important that clinicians should pay attention to the possibility of aortic dissection in a pregnant woman with chest, abdominal or back pain. In this case study, we employed Cook balloon during cesarean section to avoid anticoagulant-induced uterine bleeding during the following aortic surgery.
Undergraduate dental students’ perspective on the implementation of digital dentistry in the preclinical curriculum: a questionnaire survey
Authors: Schlenz Maximiliane Amelie , Michel Karin , Wegner Kerstin , Schmidt Alexander , Rehmann Peter , Wöstmann Bernd
Published: March 2020

Background

Digitalisation is an expanding field in dentistry and implementation of digital teaching methods in dental education is an essential part of modern education. Therefore, two digital training modules were implemented in the preclinical curriculum at the Justus Liebig University Giessen. The aim of this study was to assess the students’ perspective on the implementation with a questionnaire survey.

Methods

Since the fall term 2017/18, students of the course of dental prosthodontics I attended the training module I, where they learned to use computer-aided learning (CAL) approaches for the digital analysis of tooth preparations. In training module II, students of the course of dental prosthodontics II learned how to manufacture a computer-aided design/computer-aided manufacturing restoration. After the completion of the training modules, all students starting with the fall term 2017/18 to the spring term 2019 were asked to fill in a questionnaire regarding the aspects of handling, didactic benefit, motivation, and overall assessment.

Results

Students rated the implementation of digital aspects in teaching as positive in terms of handling, didactic benefit, and motivation, but gave preference to the assessment of the tooth preparations by dental instructors. In addition, students assessed the feedback from the faculty regarding tips and tricks better than the digital feedback. More than 90% of the students indicated that they could imagine using an intraoral scanner for treatment of patients in the dental office in future.

Conclusions

The results of the present study revealed a positive perspective of students on the implementation of digital dentistry in the preclinical curriculum. However, difficulties with CAL systems were reported and most students preferred evaluation of preparation by dental instructors. Thus, CAL approaches offer an additional teaching method besides the traditional teaching of manual skills.
Mining and visualizing high-order directional drug interaction effects using the FAERS database
Authors: Yao Xiaohui , Tsang Tiffany , Sun Qing , Quinney Sara , Zhang Pengyue , Ning Xia , Li Lang , Shen Li
Published: March 2020

Background

Adverse drug events (ADEs) often occur as a result of drug-drug interactions (DDIs). The use of data mining for detecting effects of drug combinations on ADE has attracted growing attention and interest, however, most studies focused on analyzing pairwise DDIs. Recent efforts have been made to explore the directional relationships among high-dimensional drug combinations and have shown effectiveness on prediction of ADE risk. However, the existing approaches become inefficient from both computational and illustrative perspectives when considering more than three drugs.

Methods

We proposed an efficient approach to estimate the directional effects of high-order DDIs through frequent itemset mining, and further developed a novel visualization method to organize and present the high-order directional DDI effects involving more than three drugs in an interactive, concise and comprehensive manner. We demonstrated its performance by mining the directional DDIs associated with myopathy using a publicly available FAERS dataset.

Results

Directional effects of DDIs involving up to seven drugs were reported. Our analysis confirmed previously reported myopathy associated DDIs including interactions between fusidic acid with simvastatin and atorvastatin. Furthermore, we uncovered a number of novel DDIs leading to increased risk for myopathy, such as the co-administration of zoledronate with different types of drugs including antibiotics (ciprofloxacin, levofloxacin) and analgesics (acetaminophen, fentanyl, gabapentin, oxycodone). Finally, we visualized directional DDI findings via the proposed tool, which allows one to interactively select any drug combination as the baseline and zoom in/out to obtain both detailed and overall picture of interested drugs.

Conclusions

We developed a more efficient data mining strategy to identify high-order directional DDIs, and designed a scalable tool to visualize high-order DDI findings. The proposed method and tool have the potential to contribute to the drug interaction research and ultimately impact patient health care.

Availability and implementation

http://lishenlab.com/d3i/explorer.html