bluuebunny/crossref_metadata_2025 huggingface dataset:
Low-load blood flow restriction training induces similar morphological and mechanical Achilles tendon adaptations compared with high-load resistance training
Authors: Centner Christoph , Lauber Benedikt , Seynnes Olivier R. , Jerger Simon , Sohnius Tim , Gollhofer Albert , König Daniel
Published: November 2019

Low-load blood flow restriction (LL-BFR) training has gained increasing interest in the scientific community by demonstrating that increases in muscle mass and strength are comparable to conventional high-load (HL) resistance training. Although adaptations on the muscular level are well documented, there is little evidence on how LL-BFR training affects human myotendinous properties. Therefore, the aim of the present study was to investigate morphological and mechanical Achilles tendon adaptations after 14 wk of strength training. Fifty-five male volunteers (27.9 ± 5.1 yr) were randomly allocated into the following three groups: LL-BFR [20–35% of one-repetition maximum (1RM)], HL (70–85% 1RM), or a nonexercising control (CON) group. The LL-BFR and HL groups completed a resistance training program for 14 wk, and tendon morphology, mechanical as well as material properties, and muscle cross-sectional area (CSA) and isometric strength were assessed before and after the intervention. Both HL (+40.7%) and LL-BFR (+36.1%) training induced significant increases in tendon stiffness ( P < 0.05) as well as tendon CSA (HL: +4.6%, LL-BFR: +7.8%, P < 0.001). These changes were comparable between groups without significant changes in Young’s modulus. Furthermore, gastrocnemius medialis muscle CSA and plantar flexor strength significantly increased in both training groups ( P < 0.05), whereas the CON group did not show significant changes in any of the evaluated parameters. In conclusion, the adaptive change in Achilles tendon properties following low-load resistance training with partial vascular occlusion appears comparable to that evoked by high-load resistance training.

NEW & NOTEWORTHY Low-load blood flow restriction (LL-BFR) training has been shown to induce beneficial adaptations at the muscular level. However, studies examining the effects on human tendon properties are rare. The findings provide first evidence that LL-BFR can increase Achilles tendon mechanical and morphological properties to a similar extent as conventional high-load resistance training. This is of particular importance for individuals who may not tolerate heavy training loads but still aim for improvements in myotendinous function.
Muscle pump-induced inhibition of sympathetic vasomotor outflow during low-intensity leg cycling is attenuated by muscle metaboreflex activation
Authors: Katayama Keisho , Barbosa Thales C. , Kaur Jasdeep , Young Benjamin E. , Nandadeva Damsara , Ogoh Shigehiko , Fadel Paul J.
Published: November 2019

Muscle sympathetic nerve activity (MSNA) decreases during leg cycling at low intensity because of muscle pump-induced increases in venous return and loading of the cardiopulmonary baroreceptors. However, MSNA increases during leg cycling when exercise is above moderate intensity or for a long duration, suggesting that the sympathoinhibitory effect of the cardiopulmonary baroreflex can be overridden by a powerful sympathoexcitatory drive, such as the skeletal muscle metaboreflex. Therefore, we tested the hypothesis that high-intensity muscle metaboreflex activation attenuates muscle pump-induced inhibition of MSNA during leg cycling. MSNA (left radial nerve) was recorded during graded isolation of the muscle metaboreflex in the forearm with postexercise ischemia (PEI) after low (PEI-L)- and high (PEI-H)-intensity isometric handgrip exercise (20% and 40% maximum voluntary contraction, respectively). Leg cycling (15–20 W) was performed alone and during each PEI trial (PEI-L+Cycling, PEI-H+Cycling). Cycling alone induced a significant decrease in MSNA burst frequency (BF) and total activity (TA). MSNA BF and TA also decreased when cycling was performed during PEI-L. However, the magnitude of decrease in MSNA during PEI-L+Cycling [∆BF: –19 ± 2% ( P < 0.001), ∆TA: –25 ± 4% ( P < 0.001); mean ± SE] was less than that during cycling alone [∆BF: –39 ± 5% ( P = 0.003), ∆TA: –45 ± 5% ( P = 0.002)]. More importantly, MSNA did not decrease during cycling with PEI-H [∆BF: –1 ± 2% ( P = 0.845), ∆TA: +2 ± 3% ( P = 0.959)]. These results suggest that muscle pump-induced inhibition of sympathetic vasomotor outflow during low-intensity leg cycling is attenuated by muscle metaboreflex activation in an intensity-dependent manner.

NEW & NOTEWORTHY There are no available data concerning the interaction between the sympathoinhibitory effect of muscle pump-induced cardiopulmonary baroreflex loading during leg cycling and the sympathoexcitatory influence of the muscle metaboreflex. In this study, muscle metaboreflex activation attenuated the inhibition of muscle sympathetic nerve activity (MSNA) during leg cycling. This may explain, in part, the response of MSNA to graded-intensity dynamic exercise in which low-intensity leg cycling inhibits MSNA whereas high-intensity exercise elicits graded sympathoexcitation.
Polyphyllin VII Promotes Apoptosis and Autophagic Cell Death via ROS-Inhibited AKT Activity, and Sensitizes Glioma Cells to Temozolomide
Authors: Pang Dejiang , Li Chao , Yang Chengcheng , Zou Yuanfeng , Feng Bin , Li Lixia , Liu Wentao , Geng Yi , Luo Qihui , Chen Zhengli , Huang Chao
Published: November 2019

The high recurrence frequency of gliomas but deficiency of effective treatment and prevalent chemoresistance have elicited interests in exploring and developing new agents. Paris polyphyllins are monomers extracted from rhizome of Paris polyphylla var. yunnanensis. Here, we first reported that polyphyllin VII (PP7) exhibited cytotoxic effect on glioma cells. PP7 significantly suppressed the viability and induced cell death of U87-MG and U251 cells after 24 h, with the IC50 values 4.24±0.87 μM and 2.17±0.14 μM, respectively. Both apoptotic and autophagic processes were involved in the cytotoxic effect of PP7, as PP7 activated the Bcl2/Bax pathway and the inhibition of autophagy partly rescued the toxicity of PP7 in glioma cells. In addition, an inhibition of AKT/mTORC1 activity was found after PP7 administration, and it seemed that the overproduction of reactive oxygen species (ROS) was responsible for this effect. Namely, the removal of ROS by NAC treatment mitigated PP7-induced cell death, autophagy, and its effect on the AKT/mTORC1 signaling. Additionally, a combination assay of PP7 with temozolomide (TMZ), the most used chemotherapy for glioma patients, was performed resulting in synergism, while PP7 reduced TMZ resistance through inhibition of MGMT expression. Thus, our study reports PP7 as a potential agent for glioma treatment and reveals its underlying mechanisms of action.
Evaluation of Cerebrospinal Fluid Pressure by a Formula and Its Role in the Pathogenesis of Glaucoma
Authors: Landi Laura , Casciaro Federica , Telani Serena , Traverso Carlo E. , Harris Alon , Verticchio Vercellin Alice C. , Saint Lauren , Iester Michele
Published: November 2019

Purpose. To investigate potential associations between intraocular pressure (IOP) and cerebrospinal fluid pressure (CSFP) in patients with primary open-angle glaucoma (POAG) and healthy subjects. Methods. Forty-three subjects were recruited. Weight and height were measured to calculate body mass index (BMI), along with blood pressure, heart rate, visual acuity, and IOP. Biometrics exam, corneal pachymetry, peripapillary retinal nerve fiber layer (RNFL) thickness, and macular thickness were assessed. The visual field exam was performed on all patients, and both pattern standard deviation (PSD) and mean deviation (MD) were considered. CSFP was estimated indirectly by using the mathematical formula CSFP = 0.44 × BMI + 0.16 × diastolic pressure − 0.18 × age − 1.91, based on the previous scientific studies. The TLCPD was calculated as follows: IOP−CSFP. Results. A significant (p<0.05) difference was found between the two groups for several parameters. Specifically, the CSFP was lower in patients with POAG than in healthy subjects (8.14 ± 4.52 and 7.43 ± 2.06, p<0.001, respectively). Anamnestic TLCPD was found to be significantly (p<0.001) higher in patients with POAG compared to healthy subjects. A significant (p<0.05) correlation was found between anamnestic TLCPD and MD (r = −0.31), inferior RNFL thickness (r = −0.29), superior RNFL thickness (r = −0.27), IOP (r = 0.22), and CSFP (r = −0.46). Conclusion. The CSFP was lower in glaucomatous patients compared to healthy subjects, whereas the TLCPD was higher in glaucomatous patients compared to healthy subjects, even though this difference was not statistically significant. A higher TLCPD may damage the RNFL, resulting in functional visual field impairment.
Public Procurement Announcements in Spain: Regulations, Data Analysis, and Award Price Estimator Using Machine Learning
Authors: García Rodríguez Manuel J. , Rodríguez Montequín Vicente , Ortega Fernández Francisco , Villanueva Balsera Joaquín M.
Published: November 2019

The largest project managers and adjudicators of a country, both by number of projects and by cost, are public procurement agencies. Therefore, knowing and characterising public procurement announcements (tenders) is fundamental for managing public resources well. This article presents the case of public procurement in Spain, analysing a dataset from 2012 to 2018: 58,337 tenders with a cost of 31,426 million euros. Many studies of public procurement have been conducted globally or theoretically, but there is a dearth of data analysis, especially regarding Spain. A quantitative, graphical, and statistical description of the dataset is presented. Mainly, the analysis is of the relation between the award price and the bidding price. An award price estimator is proposed that uses the random forest regression method. A good estimator would be very useful and valuable for companies and public procurement agencies. It would be a key tool in their project management decision making. Finally, a similar analysis, employing a dataset from European countries, is presented to compare and generalise the results and conclusions. Hence, this is a novel study which fills a gap in the literature.
Effects of Lighting Quality on Working Efficiency of Workers in Office Building in Tanzania
Authors: Katabaro Justine Mushobozi , Yan Yonghong
Published: November 2019

Background. In this era of Information Communication Technology, a high-quality working environment is essential to the occupants. Providing quantity rather the quality of work environments is very common in most of the least developed countries, including Tanzania. Existing research asserts that poor indoor environmental quality such as lighting has a detrimental effect on human health, and in case of the office working population, it also affects their work performance. This study aims to analyze the effects of the lighting quality on working efficiency of workers in Tanzania. Methods. Four representative offices from the administration building at Mbeya University of Science and Technology were investigated from June to September 2018. The customized questionnaire survey tool was administered to the randomly selected occupants to survey their perceptions about the quality of lighting in their workplace and its influence on their health and work efficiency. Physical observation and illuminance distribution measurements were also conducted. Results. The statistical analysis indicates that the majority of the occupants are less satisfied with the lighting quality in their working environment, and some respondents reported that it significantly affected their work efficiency and wellbeing. The average desk illuminance and uniformity level were found to be below the recommended values of the Chartered Institution of Building Services Engineers (CIBSE) and the International Commission on lighting (CIE). Conclusion. Despite the suggested improvement measures, this research emphasizes that poorly articulated work environment can adversely affect the productivity and work efficiency of the workers. The workers in such condition are also exposed to occupational diseases. Thus, providing a healthy work environment should be a fundamental right of the workers.
Design, Preparation, and Characterization of Dioscin Nanosuspensions and Evaluation of Their Protective Effect against Carbon Tetrachloride-Induced Acute Liver Injury in Mice
Authors: JU Hong-Ye , Hu Kun-Xia , Zhao Guo-Wang , Tang Zhi-Shu , Song Xiao
Published: November 2019

The purpose of this study was to prepare a dioscin nanosuspension (Dio-NS) that has a better distance and high solubility for oral administration and to evaluate its hepatoprotective effects. Optimal primary manufacture parameters, including shear time, shear speed, emulation temperature, pressure, and cycles of homogenization, were determined by single-factor experiments. The concentrations of dioscin, SDS, and soybean lecithin were optimized using the central composite design-response surface method, and their effects on the mean particle size (MPS) and particle size distribution of Dio-NS were investigated. Characterization of the Dio-NS formulations included examinations of the surface morphology and physical status of dioscin in Dio-NS, the stability of Dio-NS at different temperatures, in vitro solubility, and liver protective effect in vivo. Under optimal conditions, Dio-NS had an MPS of 106.72 nm, polydispersity index of 0.221, and zeta potential of −34.27 mV. Furthermore, the proportion of dioscin in Dio-NS was approximately 21.26%. The observation of particles with a spherical shape and the disappearance of crystalline peaks indicated that the physical and chemical properties of Dio-NS were altered. Furthermore, we observed that the dissolution of Dio-NS was superior to that of a physical mixture and Dio-GZF. Moreover, Dio-NS was demonstrated to have a protective effect against CCl4-induced acute liver damage in mice that was equivalent to that of silymarin (a positive control drug) at the same dose. The good hepatoprotective effect of our Dio-NS preparation can provide a theoretical basis for investigating its absorption mechanisms in the body.
Evaluation of Growth and Development of Late Mixed Dentition Upper Dental Arch with Normal Occlusion Using 3-Dimensional Digital Models
Authors: Yang Dapeng , Liang Shuran , Zhang Ke , Gao Weimin , Bai Yuxing
Published: November 2019

Objective. The purpose of this study was to observe the three-dimensional growth and development of the maxillary arch in 10-year-olds with normal occlusion during the late mixed dentition stage. Methods. Forty-four 10-year-old students (22 males and 22 females) who had normal occlusion during late mixed dentition were selected from an elementary school in Beijing, China. Once per year for three consecutive years, a dental cast was obtained from each subject, and the cast was scanned with a 3D digital scanner (R700 3D). The three-dimensional measurements of the maxillary dental arch and the inclination of the bilateral maxillary first molars were obtained from the digital model. Results. The upper anterior arch length (UAAL), upper total arch length (UTAL), upper inter primary or permanent canine width (UICW), upper intermolar width (UIMW), and upper dental arch length (UDAL) increased by 0.959 mm, 0.583 mm, 0.955 mm, 1.462 mm, and 2.46 mm, respectively, over the two years (P<0.001). UR6BL and UL6BL decreased by 4.416° and 7.133°, respectively, over the two years (P<0.001). The values of the UICW and UIMW were 1.67 mm and 1.86 mm, respectively, larger in males than in females at 12 years old (P<0.01). The change in the UTAL was 0.431 mm greater in males than in females over the 2 years (P<0.05). Conclusion. The UAAL, UTAL, UICW, UIMW, and UDAL in 10- to 12-year-olds with normal occlusion increased with age. The buccolingual inclination of the bilateral maxillary first molars inclined to the palatal side with age. The UICW and UIMW were larger in males than in females at 12 years old. The male UTAL increased more than the female UTAL over the 2 years.
Wheelset‐Bearing Fault Detection Using Adaptive Convolution Sparse Representation
Authors: Ding Jianming , Zhang Zhaoheng , Yin Yanli
Published: November 2019

Wheelset bearings are crucial mechanical components of high‐speed trains. Wheelset‐bearing fault detection is of great significance to ensure the safety of high‐speed train service. Convolution sparse representations (CSRs) provide an excellent framework for extracting impulse responses induced by bearing faults. However, the performance of CSR on extracting impulse responses is fairly sensitive to inappropriate selection of method‐related parameters, and a convolution model for representing the impulse responses has not been discussed. In view of these two unsolved problems, a convolutional representation model of the impulse response series is developed. A novel fault detection method, named adaptive CSR (ACSR), is then proposed based on combinations of CSR and methods for estimating three parameters related to CSR. Finally, the effectiveness of the proposed ACSR method is validated via simulation, bench testing, and a real‐life running test employing a high‐speed train.
Tetramethylpyrazine Analogue T-006 Exerts Neuroprotective Effects against 6-Hydroxydopamine-Induced Parkinson’s Disease In Vitro and In Vivo
Authors: Zhou Hefeng , Shao Min , Yang Xuanjun , Li Chuwen , Cui Guozhen , Gao Cheng , Di Lijun , Zhong Hanbing , Wang Yuqiang , Zhang Zaijun , Lee Simon Ming-Yuen
Published: November 2019

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc), and there is no cure for it at present. We have previously reported that the tetramethylpyrazine (TMP) derivative T-006 exhibited beneficial effects in Alzheimer’s disease (AD) models. However, its effect on PD remains unclear. In the present study, we investigated the neuroprotective effects and underlying mechanisms of T-006 against 6-hydroxydopamine- (6-OHDA-) induced lesions in in vivo and in vitro PD models. Our results demonstrated that T-006 alleviated mitochondrial membrane potential loss and restored the energy metabolism and mitochondrial biogenesis that were induced by 6-OHDA in PC12 cells. In addition, animal experiments showed that administration of T-006 significantly attenuated the 6-OHDA-induced loss of tyrosine hydroxylase- (TH-) positive neurons in the SNpc, as well as dopaminergic nerve fibers in the striatum, and also increased the concentration of dopamine and its metabolites (DOPAC, HVA) in the striatum. Functional deficits were restored following T-006 treatment in 6-OHDA-lesioned mice, as demonstrated by improved motor coordination and rotational behavior. In addition, we found that the neuroprotective effects of T-006 were mediated, at least in part, by the activation of both the PKA/Akt/GSK-3β and CREB/PGC-1α/NRF-1/TFAM pathways. In summary, our findings demonstrate that T-006 could be developed as a novel neuroprotective agent for PD, and the two pathways might be promising therapeutic targets for PD.
Association of Imaging-Based Body Fat Distribution and Mammographic Density in the Multiethnic Cohort Adiposity Phenotype Study
Authors: Maskarinec Gertraud , Ciba Michelle , Ju Dan , Shepherd John A. , Ernst Thomas , Wu Anna H. , Monroe Kristine R. , Lim Unhee , Wilkens Lynne R. , Le Marchand Loïc
Published: November 2019

Background:

As the stronger association of obesity with postmenopausal breast cancer in Asian than white women may be due to body fat distribution, we examined the relation of adiposity measures with percent mammographic density (PMD), a strong predictor of breast cancer incidence.

Methods:

A total of 938 women from five ethnic groups (69.1 ± 2.7 years) in the Adiposity Phenotype Study (APS) underwent DXA and MRI imaging. PMD was assessed in routine mammograms using a computer-assisted method. Spearman correlation coefficients were computed and general linear models were applied to estimate regression coefficients (β) for PMD per 0.5 SD units of adiposity measures while adjusting for known confounders, including DXA total body fat.

Results:

For 701 (75%) of the participants (69.1 ± 2.7 years), valid mammograms were obtained. Whereas total body fat, the trunk-to-periphery fat ratio (TPFR), visceral fat (VAT), and subcutaneous fat (SAT) were inversely correlated with PMD (P < 0.0001), the VAT/SAT ratio correlated positively (rspearman = 0.10; P = 0.01). In fully adjusted models, PMD remained inversely related to TPFR and SAT and disappeared for VAT, while it was strengthened for VAT/SAT (β = 0.51; P = 0.009). This relation was stronger in Japanese Americans than other ethnic groups.

Conclusions:

This is the first study to show an association of a high VAT/SAT ratio with greater PMD, a marker of breast cancer risk after taking into account total body fat.

Impact:

The results indicate a link between the propensity to accumulate VAT and the amount of fat in the breast (1-PMD), which may influence the relation of obesity with breast cancer incidence.
Genomics and Targeted Therapies in Gastroesophageal Adenocarcinoma
Authors: Nagaraja Ankur K. , Kikuchi Osamu , Bass Adam J.
Published: November 2019

Gastroesophageal adenocarcinomas (GEA) are devastating diseases with stark global presence. Over the past 10 years, there have been minimal improvements in treatment approach despite numerous clinical trials. Here, we review recent progress toward understanding the molecular features of these cancers and the diagnostic and therapeutic challenges posed by their intrinsic genomic instability and heterogeneity. We highlight the potential of genomic heterogeneity to influence clinical trial outcomes for targeted therapies and emphasize the need for comprehensive molecular profiling to guide treatment selection and adapt treatment to resistance and genomic evolution. Revising our clinical approach to GEA by leveraging genomic advances will be integral to the success of current and future treatments, especially as novel targets become therapeutically tractable.

Significance:

GEAs are deadly cancers with few treatment options. Characterization of the genomic landscape of these cancers has revealed considerable genetic diversity and spatial heterogeneity. Understanding these fundamental properties of GEA will be critical for overcoming barriers to the development of novel, more effective therapeutic strategies.
Overexpression of miR-150 Inhibits the NF-κB Signal Pathway in Intervertebral Disc Degeneration through Targeting P2X7
Authors: Zhang Yan , Zhang Yi-Shu , Li Xiao-Juan , Huang Chao-Rong , Yu Hui-Jin , Yang Xiao-Xia , Wang Bin-Xiong
Published: November 2019

Objective: To elaborate the mechanism of miR-150 in the regulation of the NF-κB signal pathway in intervertebral disc degeneration (IDD) by targeting P2X7. Methods: The degenerative and normal intervertebral disc tissues were collected to detect the expressions of miR-150 and P2X7. Nucleus pulposus cells were transfected and divided into different groups. Cell apoptosis was determined by flow cytometry and TUNEL staining. The expressions of IL-6, TNF-α, MMP-3, MMP-13, Cox-2, iNOS, collagen II and aggrecan, as well as NF-κB-associated proteins were measured by qRT-PCR and Western blotting. Furthermore, IDD rat models were established to validate the role of miR-150 in vivo.Results: miR-150 was down-regulated but P2X7 was up-regulated in the degenerative intravertebral disc tissues. The apoptosis of nucleus pulposus cells in the IL-1β-induced group with the transfection of miR-150 mimic and siP2X7 was significantly decreased, with reduced levels of IL-6, TNF-α, MMP-3, MMP-13, Cox-2 and iNOS, increased levels of collagen II and aggrecan, as well as decreased P2X7, p-p65/p65 and cleaved caspase-3. However, the above factors showed an opposite tendency after treatment with miR-150 inhibitor. Furthermore, the P2X7 siRNA transfection could reverse the effects caused by miR-150 inhibitor. Simultaneously, pcDNA P2X7 transfection also inhibited the function of miR-150 mimic in IL-1β-induced nucleus pulposus cells. In vivoexperiments further verified the protective role of miR-150 in IDD rats. Conclusion: miR-150 may alleviate the degeneration of the intervertebral disc partially since it could restrict the NF-κB pathway by targeting P2X7, and thereby inhibiting IL-1β-induced matrix catabolism, inflammatory responses and apoptosis of the nucleus pulposus cells.
Frequency of Mia (MNS7) and Classification of Mia-Positive Hybrid Glycophorins in an Australian Blood Donor Population
Authors: Lopez Genghis H. , Wilson Brett , Turner Robyn M. , Millard Glenda M. , Fraser Nicole S. , Roots Naomi M. , Liew Yew-Wah , Hyland Catherine A. , Flower Robert L.
Published: November 2019

Background: MNS blood group system genes GYPA and GYPB share a high degree of sequence homology and gene structure. Homologous exchanges between GYPA and GYPB form hybrid genes encoding hybrid glycophorins GP(A-B-A) and GP(B-A-B). Over 20 hybrid glycophorins have been characterised. Each has a distinct phenotype defined by the profile of antigens expressed including Mia. Seven hybrid glycophorins carry Mia and have been reported in Caucasian and Asian population groups. In Australia, the population is diverse; however, the prevalence of hybrid glycophorins in the population has never been determined. The aims of this study were to determine the frequency of Mia and to classify Mia-positive hybrid glycophorins in an Australian blood donor population. Method: Blood samples from 5,098 Australian blood donors were randomly selected and screened for Mia using anti-Mia monoclonal antibody (CBC-172) by standard haemagglutination technique. Mia-positive red blood cells (RBCs) were further characterised using a panel of phenotyping reagents. Genotyping by high-resolution melting analysis and DNA sequencing were used to confirm serology. Result: RBCs from 11/5,098 samples were Mia-positive, representing a frequency of 0.22%. Serological and molecular typing identified four types of Mia-positive hybrid glycophorins: GP.Hut (n = 2), GP.Vw (n = 3), GP.Mur (n = 5), and 1 GP.Bun (n = 1). GP.Mur was the most common. Conclusion: This is the first comprehensive study on the frequency of Mia and types of hybrid glycophorins present in an Australian blood donor population. The demographics of Australia are diverse and ever-changing. Knowing the blood group profile in a population is essential to manage transfusion needs.
2019 American Heart Association and American Red Cross Focused Update for First Aid: Presyncope: An Update to the American Heart Association and American Red Cross Guidelines for First Aid
Authors: Charlton Nathan P. , Pellegrino Jeffrey L. , Kule Amy , Slater Tammy M. , Epstein Jonathan L. , Flores Gustavo E. , Goolsby Craig A. , Orkin Aaron M. , Singletary Eunice M. , Swain Janel M.
Published: November 2019

This 2019 focused update to the American Heart Association and American Red Cross first aid guidelines follows the completion of a systematic review of treatments for presyncope of vasovagal or orthostatic origin. This review was commissioned by the International Liaison Committee on Resuscitation and resulted in the development of an international summary statement of the International Liaison Committee on Resuscitation First Aid Task Force Consensus on Science With Treatment Recommendations. This focused update highlights the evidence supporting specific interventions for presyncope of orthostatic or vasovagal origin and recommends the use of physical counterpressure maneuvers. These maneuvers include the contraction of muscles of the body such as the legs, arms, abdomen, or neck, with the goal of elevating blood pressure and alleviating symptoms. Although lower-body counterpressure maneuvers are favored over upper-body counterpressure maneuvers, multiple methods can be beneficial, depending on the situation.
Comparative Performance of Prediction Models for Contrast-Associated Acute Kidney Injury After Percutaneous Coronary Intervention
Authors: Ma Bryan , Allen David W. , Graham Michelle M. , Har Bryan J. , Tyrrell Ben , Tan Zhi , Spertus John A. , Brown Jeremiah R. , Matheny Michael E. , Hemmelgarn Brenda R. , Pannu Neesh , James Matthew T.
Published: November 2019

Background:

Identifying patients at increased risk of contrast-associated acute kidney injury (CA-AKI) can help target risk mitigation strategies toward these individuals during percutaneous coronary intervention. Illuminating which risk models best stratify risk is an important foundation for such quality improvement efforts.

Methods and Results:

Seven previously published risk prediction models for CA-AKI and 3 models for kidney injury requiring dialysis were validated using 2 definitions for CA-AKI (the Kidney Disease: Improving Global Outcomes definition of ≥0.3 mg/dL within 48 hours or ≥50% increase in serum creatinine from baseline within 7 days and the historical definition of ≥0.5 mg/dL or ≥25% increase in serum creatinine from baseline within 48 hours), and AKI requiring dialysis within 30 days of percutaneous coronary intervention. Model performance was compared based on discrimination, calibration, and categorical net reclassification index before and after model recalibration. Among 7888 patients who underwent percutaneous coronary intervention in Alberta Canada, CA-AKI occurred in 330 patients (4.2%) when CA-AKI was defined using the Kidney Disease: Improving Global Outcomes definition and 571 (7.3%) when using the historical definition. CA-AKI requiring dialysis occurred in 42 (0.6%) patients. When validated using the Kidney Disease: Improving Global Outcomes definition for CA-AKI, the 2 most recently published models for CA-AKI showed better discrimination (C statistics, 0.75–0.76) than older models (C statistics, 0.61–0.68). C statistics of models for kidney injury requiring dialysis ranged from 0.70 to 0.86. The calibration of all models for CA-AKI deviated from ideal, and the proportion of patients classified into different risk categories for CA-AKI differed substantially for the 2 most recent models. Recalibration significantly improved risk stratification of patients into clinical risk categories for some models.

Conclusions:

Recent prediction models for CA-AKI show better discrimination compared with older models; however, model recalibration should be examined in external cohorts to improve the accuracy of predictions, particularly if predicted risk strata are used to guide management approaches.
Arts Nonprofits—Associations and Agencies: A Literature Review
Authors: Stebbins Robert A.
Published: November 2019

An association is “a relatively formally structured nonprofit group that depends mainly on volunteer members for participation and activity and that primarily seeks member benefits, even if it may also seek some public benefits” (Smith, Stebbins, & Dover, 2006, p. 23). The arts that give birth to these organizations can be classified as either fine art or entertainment art. Every art association is embedded each in its own art world and its own social world. Members of these association are mostly amateurs or hobbyists in their art.

Publications on arts-related amateur, hobbyist, professional, and mixed-member associations are reviewed. Their prime mission is to foster, present, and sometimes chronicle the art that its members prize. Many of these works report on the structure of the associations as well as on the recruitment, artistic development, deployment of artists, dissemination of their art, and retention of their members. Also reviewed is a selection of publications bearing on what could be called “arts consumption clubs,” or groups such as book clubs, dance clubs, and jazz clubs established to generate interest in a given art. Some of the publications reviewed center on associational management, use of volunteers, and financial base of the group.
Pinguicula simulans (Lentibulariaceae), a new species from Nuevo León, Mexico

Authors: ZAMUDIO SERGIO , SALINAS-RODRÍGUEZ MARÍA MAGDALENA , QUIRINO-OLVERA RICARDO , HERNÁNDEZ-RENDÓN JULIÁN
Published: November 2019

Pinguicula simulans (Lentibulariaceae), a new species endemic to Sierra Madre Oriental, is described and illustrated from plants collected at Potrero Redondo, municipality of Santiago, Nuevo Léon, Mexico. Its flowers are similar to those of P. gracilis and the new species therefore belongs to Pinguicula subg. Temnoceras, sect. Microphyllum. It differs from other species in the section by the spatulate winter leaves, which are longer than wide, with a slightly recurved apex. In addition, it is distinguished by the long spatulate, ascendant or diffuse, recurved, summer leaves, which form a loose rosette, and by the calyx that has glandular pubescence on both surfaces.
Development of Community, Capabilities, and Understanding through Unmanned Aircraft-Based Atmospheric Research: The LAPSE-RATE Campaign
Authors: de Boer Gijs , Diehl Constantin , Jacob Jamey , Houston Adam , Smith Suzanne W. , Chilson Phillip , Schmale David G. , Intrieri Janet , Pinto James , Elston Jack , Brus David , Kemppinen Osku , Clark Alex , Lawrence Dale , Bailey Sean C. C. , Sama Michael P. , Frazier Amy , Crick Christopher , Natalie Victoria , Pillar-Little Elizabeth , Klein Petra , Waugh Sean , Lundquist Julie K. , Barbieri Lindsay , Kral Stephan T. , Jensen Anders A. , Dixon Cory , Borenstein Steven , Hesselius Daniel , Human Kathleen , Hall Philip , Argrow Brian , Thornberry Troy , Wright Randy , Kelly Jason T.
Published: November 2019

Because unmanned aircraft systems (UAS) offer new perspectives on the atmosphere, their use in atmospheric science is expanding rapidly. In support of this growth, the International Society for Atmospheric Research Using Remotely-Piloted Aircraft (ISARRA) has been developed and has convened annual meetings and “flight weeks.” The 2018 flight week, dubbed the Lower Atmospheric Profiling Studies at Elevation–A Remotely-Piloted Aircraft Team Experiment (LAPSE-RATE), involved a 1-week deployment to Colorado’s San Luis Valley. Between 14 and 20 July 2018 over 100 students, scientists, engineers, pilots, and outreach coordinators conducted an intensive field operation using unmanned aircraft and ground-based assets to develop datasets, community, and capabilities. In addition to a coordinated “Community Day” which offered a chance for groups to share their aircraft and science with the San Luis Valley community, LAPSE-RATE participants conducted nearly 1,300 research flights totaling over 250 flight hours. The measurements collected have been used to advance capabilities (instrumentation, platforms, sampling techniques, and modeling tools), conduct a detailed system intercomparison study, develop new collaborations, and foster community support for the use of UAS in atmospheric science.
Using Visualization Science to Improve Expert and Public Understanding of Probabilistic Temperature and Precipitation Outlooks
Authors: Gerst Michael D. , Kenney Melissa A. , Baer Allison E. , Speciale Amanda , Wolfinger J. Felix , Gottschalck Jon , Handel Scott , Rosencrans Matthew , Dewitt David
Published: November 2019

Visually communicating temperature and precipitation climate outlook graphics is challenging because it requires the viewer to be familiar with probabilities as well as to have the visual literacy to interpret geospatial forecast uncertainty. In addition, the visualization scientific literature has open questions on which visual design choices are the most effective at expressing the multidimensionality of uncertain forecasts, leaving designers with a lack of concrete guidance. Using a two-phase experimental setup, this study shows how recently developed visualization diagnostic guidelines can be used to iteratively diagnose, redesign, and test the understandability the U.S. National Oceanic and Atmospheric Administration (NOAA) Climate Prediction Center (CPC) climate outlooks. In the first phase, visualization diagnostic guidelines were used in conjunction with interviews and focus groups to identify understandability challenges of existing visual conventions in temperature and precipitation outlooks. Next, in a randomized control versus experimental treatment setup, several graphic modifications were produced and tested via an online survey of end users and the general public. Results show that, overall, end users exhibit a better understanding of outlooks, but some types of probabilistic color mapping are misunderstood by both end users and the general public, which was predicted by the diagnostic guidelines. Modifications lead to significant gains in end-user and general public understanding of climate outlooks, providing additional evidence for the utility of using control versus treatment testing informed by visualization diagnostics.
Prognostic Value of Lipoprotein(a) Levels in Patients Undergoing Coronary Angiography for Premature Acute Coronary Syndromes
Authors: Wang Le , Cong Hongliang , Zhang Jingxia , Hu Yuecheng , Wei Ao , Zhang Yingyi
Published: November 2019

Little is known about the association between lipoprotein(a) [Lp(a)] levels and future ischemic cardiovascular events in patients with premature acute coronary syndrome (ACS). A total of 1464 consecutive patients who underwent coronary angiography for premature ACS (males <45 years and females <55 years) were enrolled in this study. Patients were divided into quartiles according to serum Lp(a) levels (Q1: ≤11.1 nmol/L; Q2: 11.1-27.7 nmol/L; Q3: 27.7-79.3 nmol/L; and Q4: >79.3 nmol/L). Major adverse cardiovascular events (MACEs) increased with Lp(a) quartiles after 2-year follow-up (among quartiles, respectively; P = .001). Kaplan-Meier curves revealed significant differences in event-free survival rates among Lp(a) quartile groups ( P = .001). Multivariate Cox proportional hazards regression analysis indicated that serum Lp(a) level was an independent predictor of MACE either as a continuous variable (hazard ratio [HR]: 1.002, 95% confidence interval [CI]: 1.001-1.004; P = .009) or as a categorical variable (HR: 1.443, 95% CI: 1.074-1.937; P = .015). Furthermore, Lp(a) levels (as a variable) significantly improved the prognostic value for MACE. These findings suggest that Lp(a) measurement has value for cardiovascular risk stratification in patients with premature ACS.
Handheld X-ray Fluorescence (XRF) Versus Wavelength Dispersive XRF: Characterization of Chinese Blue-and-White Porcelain Sherds Using Handheld and Laboratory-Type XRF Instruments
Authors: Simsek Franci Gulsu
Published: November 2019

Almost all archaeometric studies on Chinese ceramics are carried out on the excavation materials. Therefore, a detailed, comparable database that defines different workshops and production periods already exists. But the masterpieces preserved at museums, art galleries, and/or private collections, which are artistically considered as genuine artifacts, also require similar scientific investigations to define their provenance and authenticity. The research on artworks is only possible with the use of portable, noninvasive techniques that are developing daily concerning their capability of detection limits, rate of measurement, and ease of use. In this study, the results obtained with a handheld X-ray fluorescence (XRF) (also called portable XRF) and wavelength dispersive XRF instrument were compared to evidence the efficiency and drawbacks of the portable model. To achieve this goal, 12 sherds, which represent blue-and-white porcelains of Yuan and Ming Dynasties (China), were analyzed and the chemical composition of the body, glaze, and blue decor were identified. The comparison of the results with the measurements carried out on the excavation materials, which are produced in both southern and northern China, revealed the authenticity of the artifacts. Even sodium cannot be detected with portable XRF, the distinction of different production centers is possible with the detection of major (Mg, Al, Si, K, Ca), minor (Fe, Ti), and trace elements (Zr, Sr, Rb).
Effects of long-term antipsychotics treatment on body weight: A population-based cohort study
Authors: Bazo-Alvarez Juan Carlos , Morris Tim P , Carpenter James R , Hayes Joseph F , Petersen Irene
Published: November 2019

Background:

Antipsychotics are often prescribed for long-term periods, however, most evidence of their impact on body weight comes from short-term clinical trials. Particularly, impact associated with dosage has been barely studied.

Aims:

The aim of this study was to describe the short- and long-term change in body weight of people initiated on high or low doses of the three most commonly prescribed second-generation antipsychotics.

Methods:

Retrospective cohorts of individuals with a diagnosed psychotic disorder observed from 2005 to 2015 in the UK primary care. The exposure was the first prescription of olanzapine, quetiapine or risperidone. The main outcome was change in body weight four years before and four years after initiation of antipsychotic treatment, stratified on sex and ‘low’ or ‘high’ dose.

Results:

In total, 22,306 women and 16,559 men were observed. Olanzapine treatment was associated with the highest change in weight, with higher doses resulting in more weight gain. After 4 years, given a high dose of olanzapine (> 5 mg), women gained on average +6.1 kg; whereas given a low dose (⩽ 5 mg), they gained +4.4 kg. During the first six weeks of olanzapine treatment, they gained on average +3.2 kg on high dose and +1.9 kg on low dose. The trends were similar for men. Individuals prescribed risperidone and quetiapine experienced less weight gain in both the short- and long-term.

Conclusions:

Olanzapine treatment was associated with the highest increase in weight. Higher doses were associated with more weight gain. Doctors should prescribe the lowest effective dose to balance mental-health benefits, weight gain and other adverse effects.
Characterizing pulsatility in distal cerebral arteries using 4D flow MRI
Authors: Vikner Tomas , Nyberg Lars , Holmgren Madelene , Malm Jan , Eklund Anders , Wåhlin Anders
Published: November 2019

Recent reports have suggested that age-related arterial stiffening and excessive cerebral arterial pulsatility cause blood–brain barrier breakdown, brain atrophy and cognitive decline. This has spurred interest in developing non-invasive methods to measure pulsatility in distal vessels, closer to the cerebral microcirculation. Here, we report a method based on four-dimensional (4D) flow MRI to estimate a global composite flow waveform of distal cerebral arteries. The method is based on finding and sampling arterial waveforms from thousands of cross sections in numerous small vessels of the brain, originating from cerebral cortical arteries. We demonstrate agreement with internal and external reference methods and show the ability to capture significant increases in distal cerebral arterial pulsatility as a function of age. The proposed approach can be used to advance our understanding regarding excessive arterial pulsatility as a potential trigger of cognitive decline and dementia.
Caregiver Decision-Making for Terminally Ill Children: A Qualitative Study
Authors: Pinto Taylor Emily , Doolittle Benjamin
Published: November 2019

Introduction:

Many children are born with life-limiting illnesses. Medical decision-making for these children by caregivers is complex and causes significant psychosocial distress, which can be partially alleviated by effective communication with medical providers. In order for providers to support caregivers, this study explores how caregivers make decisions regarding the medical care of their terminally ill children.

Methods:

Semistructured interviews were conducted among caregivers of terminally ill children. Participation was voluntary and confidential. The institutional review board approved the protocol. Transcripts were read and coded by 2 authors using inductive, concurrent analysis to reach thematic saturation and generate common themes.

Results:

Nine interviews were completed, discussing the care of 10 children. Caregivers described decision-making as impacted by their relationships with medical providers of 2 distinct types—trusting and nontrusting. Trusting relationships were notable for a longitudinal relationship with medical staff who empowered caregivers and treated the patient primarily as a child. Nontrusting relationships were noted when the medical team objectified their child as a “patient” and appeared to withhold information. Also, nontrusting relationships occurred when caregivers felt frustration with needing to educate health-care providers about their child’s illness.

Conclusion:

Decision-making by caregivers of terminally ill children is complex, and supporting families in this process is a critical role of all medical providers. A trusting relationship with medical team members was identified as an effective tool for well-supported decision-making, which can potentially alleviate the suffering of the child and distress of the caregivers during this emotionally charged time.
Characterization and evaluation of a novel O-carboxymethyl chitosan films with Mimosa tenuiflora extract for skin regeneration and wound healing
Authors: Valencia-Gómez Laura-Elizabeth , Martel-Estrada Santos-Adriana , Vargas-Requena Claudia-Lucia , Acevedo-Fernández Juan-José , Rodríguez-González Claudia-Alejandra , Hernández-Paz Juan-Francisco , Santos-Rodríguez Elí , Olivas-Armendáriz Imelda
Published: November 2019

In this study, films of O-carboxymethyl chitosan with Mimosa tenuiflora extract were manufactured, characterized, and evaluated. In this work, both the synthesis of O-carboxymethyl chitosan and the extraction of the active ingredient of Mimosa tenuiflora extract from the cortex are described. First, the extract of Mimosa tenuiflora in water was obtained by precipitation with ethanol, filtering, and concentrating. Subsequently, a study was conducted of scratch wound healing to determine the optimal concentration of extract to be used in the manufacture of films. The produced O-carboxymethyl chitosan films and the Mimosa tenuiflora extract were mixed, and their chemical composition, tensile properties, and wettability were characterized by Fourier-transform infrared spectroscopy, mechanical tests, and contact angle measurement. The antimicrobial properties of the films were tested by turbidimetry using two types of bacteria. In addition, a study of the enzymatic degradation of the films with the enzyme lysozyme was performed. Finally, in vitro studies to assess the biocompatibility and cytotoxicity of films with fibroblastic cells were carried out as well as the kinetic analysis of healing in mice. It was found that the addition of Mimosa tenuiflora extract in the polymer matrix of the films made with O-carboxymethyl chitosan improves the proliferation of fibroblast and accelerates wound healing, thus providing a novel biomaterial for skin regeneration.