bluuebunny/crossref_metadata_2025 huggingface dataset:
10. Dutch Peat
Authors: Sintobin Tom
Published: July 2023

In this article Tom Sintobin studies the way Dutch artists have used peat as an artistic material in the 21st century.
20. Mylar Foil: Blankets of Silver and Gold
Authors: Boom Jeroen
Published: July 2023

Within the endless circulation of contemporary media images, a common visual trope has emerged in which refugees arriving on European beaches are covered in blankets of silver and gold. Besides materials such as rubber (life vests, rafts), wood (boats, shelters), and paper (invalid passports, washed-up photographs), these sheets of mylar heat foil belong to an ecology of circulating matter within the Mediterranean border zones. In this chapter, Jeroen Boom will look at several images and video artworks as temporary semiotic fixations of this flow of meaning and matter in the context of what has come to be known as the European "refugee crisis." His focus lies with the materiality of the mylar foil, which, as new materialist thinkers such as Karen Barad and Jane Bennett claim, is not inert or passive, neither permanent nor determinate, but produced in performative materializations, in material enactments of boundaries and fixations. The reflective thermal material, apart from its compression of different plastic and metallic materials, also produces, and is imbued with, conflicting layers of signification. From matter to metaphor, in the specific context of images of migration, the golden foil goes from a tool of humanitarian help to a trope of massification and desubjectification to a symbol of plastic pollution and ecological debris.
Framing Fragments The Image, Modernity, and Architecture
Authors: Sanyal Saptarshi
Published: July 2023

By focusing on how image making practices and architecture are inextricable from one another, in this essay, Saptarshi Sanyal explores some ways in which the photograph is a site of architectural production. Sanyal views the postcard as an artefact of popular cultures over time, draws attention to its representation of fragments of urban and architectural modernity, while also simultaneously underscoring the uneven nature of such modernity. Studying the photographic gaze then becomes an important agenda in uncovering new histories of modernity that, rather than clear, colonial taxonomies and categories linked to places, races or societies, are contested and plural.
The Avatar's Body in Game Spaces
Authors: Günzel Stephan
Published: July 2023

Stephan Günzel explores the relationship between the human body, spatial perception, and the representation of space in computer games. Drawing on phenomenological concepts, the article argues that the body serves as the medium through which individuals experience space. Computer games can modify and extend the body's spatial capabilities, offering unique perspectives and experiences. Furthemore discussed is the role of simulation images in shaping spatial perception and introduces the notion of the avatar as a means of interacting with game-spaces. It compares different game genres, highlighting the ways in which they simulate bodily movement and navigate virtual environments.
Caso Clínico: Retiro de dispositivo de oclusión y cierre de Comunicación Interauricular con redirección de flujo de venas pulmonares
Authors: López Rodríguez Javier Arturo , Flores Siguenza Juan Bernardo , Haro Moyón Luis Felipe , Marín Valencia Lady , Arévalo Placencia Gabriela Elizabeth , Arévalo Placencia Daniela Lisbeth
Published: July 2023

BACKGROUND: Atrial septal defect represents 10 to 15% of congenital heart disease and is more frequent in women with a 2:1 ratio. Sinus venosus atrial septal defect is usually associated with partial anomalous pulmonary venous drainage from the right superior pulmonary vein to the right atrium directly or indirectly through the superior vena cava. Rarer still, is the inferior sinus venosus, which may be associated with partial anomalous venous drainage from the right inferior pulmonary vein. CASE REPORT: 13-year-old patient with a history of intervention for interatrial defect closure with Amplatzer occluder at the age of six. He was brought to receive medical attention for fatigue and dyspnea that had been progressing for 2 years. Cardiac CT reported partial anomalous connection of pulmonary veins and echocardiogram reported a residual atrial septal defect of 10 mm and mild to moderate pulmonary hypertension. Based on the findings, surgical treatment was decided. EVOLUTION: In correction surgery, we observed Amplatzer occluder incorrectly positioned, the device was removed and flow was redirected from right pulmonary veins to left atrium with bovine pericardium patch. After the surgical intervention, the patient had a favorable evolution without no post-surgical complications. At follow-up, 15 days after medical discharge, the patient was asymptomatic, and a cardiac CT scan showed the corrected interatrial defect. CONCLUSION: The treatment of atrial septal defect should be individualized, since it will depend on the size of the defect, the age at the time of diagnosis, the magnitude of the shunt, the severity of the symptoms and the presence of other conditions. If the defect requires repair, it is important to weigh the benefits of choosing percutaneous closure vs. surgical intervention to avoid the need for reintervention, as in the present case. Closure and redirection of pulmonary vein flow with bovine patch is a safe and effective option.
Cover Jurnal Fitopatologi Vol. 19 No. 3, Mei 2023
Authors: Editors Jurnal Fitopatologi Indonesia
Published: July 2023

This editorial contains the front cover, editorial page, and back cover of the Jurnal Fitopatologi Indonesia Vol. 19 No. 3, May 2023
Breastfeeding Self-Efficacy di Wilayah Kerja Puskesmas Batang 1
Authors: Kabariyah Kabariyah , Anggorowati Anggorowati
Published: July 2023

Self-efficacy berpengaruh dalam pemberian ASI eksklusif, namun cakupan ASI eksklusif di wilayah kerja Puskesmas Batang 1 masih rendah. Penelitian sebelumnya menggambarkan self-efficacy ibu primigravida tinggi, dan hubungan bermakna status pekerjaan ibu dalam pemberian ASI ekslusif, sedangkan belum terdapat penelitian terkait gambaran beastfeeding self efficacy pada ibu bekerja dan tidak bekerja. Penelitian ini bertujuan untuk mengetahui gambaran tingkat breastfeeding self-efficacy pada ibu bekerja dan tidak bekerja. Desain penelitian deskriptif dengan pendekatan survei dengan sampel sebanyak 164 ibu menyusui dengan anak usia 6-12 bulan yaitu 59 ibu bekerja dan 115 ibu tidak bekerja dengan teknik pengambilan sampel purposive. Penelitian dilakukan di wilayah kerja Puskesmas Batang 1 dengan instrumen Breastfeeding Self-Efficacy Scale Short Form (BSES-SF). Data dianalis menggunakan distribusi frekuensi dan presentase. Hasil penelitian menunjukkan bahwa tingkat breastfeeding self-efficacy ibu bekerja 14,3% rendah, 65,3% sedang, dan 20,4% tinggi. Tingkat breastfeeding self-efficacy ibu tidak bekerja yaitu 9,6% rendah, 73,0% sedang, dan 17,4% tinggi. Pelayanan kesehatan diharapkan memberikan edukasi kesehatan untuk meningkatkan pengetahuan, motivasi, keyakinan diri ibu dalam memberikan ASI kepada bayinya. Peneliti selanjutnya diharapkan mengkaji faktor-faktor breastfeeding self-efficacy ibu bekerja dan tidak bekerja memberikan ASI
“The Want of Accurate Maps”: On Using Period Maps in Research for the Battle of Monmouth Courthouse
Authors: Timpanaro Michael , Pidermann Victor
Published: July 2023

This paper presents an analysis of period military maps associated with the Battle of Monmouth Courthouse, and in so doing, encourages researchers of such maps to consult the perspective of the mapmaker and the context surrounding the document. Modernity tends to consider maps as accurate, objective portrayals of events, and modern scholars are overly critical or dismissive of historic maps when divergent or inaccurate features are presented. This mindset may not be appropriate; period maps should not be thought of as merely historic versions of today’s satellite images, but rather as depicting the perspective of the draftsman or commissioner of the map, which of itself may harbor important insights to discover.           

In examining this point, American, French, British, and Hessian maps developed in the aftermath of the battle were consulted, focusing on the important features of each illustration, the backgrounds of the relevant draftsmen and/or commissioners, and their possible motivations and objectives in making the maps. The ultimate goal emphasized by this piece is that the wise historical researcher of military maps from this period should remember that the depiction of positions and events should be perceived through the eyes of the individuals responsible for the map’s creation, and not taken at face value.
The Story Behind the Story: Telling the History of Colonel Tye at Sandy Hook
Authors: Palfreyman Brett
Published: July 2023

The National Park Service and the Sandy Hook Foundation are in the midst of creating an educational experience to tell the story of Colonel Tye, the runaway slave who joined British forces at Sandy Hook and became one of the most feared fighters of the American Revolution in New Jersey. This article summarizes their efforts to create a rich, immersive narrative for public audiences, despite the challenge that surviving documents about him, mostly written by those who enslaved him and fought against him, are scarce and often scant on details.
Denville in World War II
Authors: Chappine Patricia
Published: July 2023

Patricia Chappine reviewing Denville in World War II, by Peter Zablocki.
Erratum: The Shady Side of the Lens: Six Lawbreaking Nineteenth-Century New Jersey Photographers
Authors: Saretzky Gary D.
Published: July 2023

This erratum corrects an oversight in the Winter 2023 publishing of the article "The Shady Side of the Lens: Six Lawbreaking Nineteenth-Century New Jersey Photographers."
State Entrepreneurship in Interwar Poland
Authors: Kaliński Janusz
Published: July 2023

State entrepreneurship, or rather statism, was a strongly developed phenomenon in the economy of interwar Poland. Initially, its source was the legacy of the partition period in the form of the considerable assets of the partitioned states, numerous industrial plants, banks, transport infrastructure, forests and land. In a reborn Poland, in order to strengthen the economy and military potential, the authorities undertook, among other things, a number of industrial investments, developed state-owned banking and transport enterprises and organised profitable treasury monopolies. The share of the state sector in the economy reached 20%, and in some areas even 100%. Researchers of state entrepreneurship, usually, have emphasised its considerable economic efficiency and important social role.
Gagliardo-Nirenberg-type inequalities using fractional Sobolev spaces and Besov spaces
Authors: Dao Nguyen Anh
Published: July 2023

Our main purpose is to establish Gagliardo-Nirenberg-type inequalities using fractional homogeneous Sobolev spaces and homogeneous Besov spaces. In particular, we extend some of the results obtained by the authors in previous studies.
Determination of polyphenols in Chinese jujube using ultra-performance liquid chromatography–mass spectrometry
Authors: Liu Hongxia , Guo Xiaohua , Wu Jingjie , Liu Hui , Deng Benliang , Zhao Xusheng
Published: July 2023

The polyphenolic composition of the same variety of winter jujube was determined using ultra-performance liquid chromatography–mass spectrometry (UPLC–MS/MS). A metabolomic approach was employed to determine polyphenols at different developmental stages (S1, S2, and S3). The total phenolic content of Chinese jujube was quantified, and the metabolites were statistically analyzed using orthogonal partial least squares discriminant analysis (OPLS-DA) for differential metabolite screening and clustering analysis of key components. The findings revealed that 128 polyphenolic components of Chinese jujube had been identified. Different developmental periods could not be clearly distinguished in principal component analysis, and there was a crossover between S2 and S3 stages. In contrast, the OPLS-DA score plot could effectively distinguish between samples of different developmental periods, and its differential metabolites could be visualized by a volcano plot based on OPLS-DA. Ten phenolic differential metabolites in different developmental periods were clustered and analyzed, among which N′-p-coumaroylguanidinium, N-p-coumaroylbutylamine, caffeoyl guanidinium, N-feruloyl guanidinium, pianoside, isorhamnetin 5-O-hexoside, isorhamnetin O-acetyl-hexoside, quercetin, and lignan O-hexosyl-O-pentoside were higher in the S1 period and chrysoeriol 6-C-hexoside was higher in the S2 and S3 periods. In this study, the differences in jujube polyphenols were elucidated, which provided scientific guidance for the application of jujube polyphenols.
A new finite-element procedure for vibration analysis of FGP sandwich plates resting on Kerr foundation
Authors: Do Ngoc-Tu , Tran Trung Thanh , Pham Quoc-Hoa
Published: July 2023

This article provides a new finite-element procedure based on Reddy’s third-order shear deformation plate theory (TSDT) to establish the motion equation of functionally graded porous (FGP) sandwich plates resting on Kerr foundation (KF). Although Reddy’s TSDT is attractive, it cannot be exploited as expected in finite-element analysis due to the difficulties in satisfying the zero shear stress boundary condition. In this study, the proposed element has four nodes, each with seven degrees of freedom (DOF). The performance of this element is confirmed by conducting various examples, showing its accuracy and range of applications. Then, some studies are performed to present the effects of input parameters on the vibration of FGP sandwich plates resting on KF.
Inverse scattering problem for nonstrict hyperbolic system on the half-axis with a nonzero boundary condition
Authors: Ismailov Mansur I. , Kal’menov Tynysbek S.
Published: July 2023

The paper considers the scattering problem for the first-order system of hyperbolic equations on the
half-axis with a nonhomogeneous boundary condition. This problem models the
phnomennon of wave propagation in a nonstationary medium where an incoming
wave unaffected by a potential field. The scattering operator on the
half-axis with a nonzero boundary condition is defined and the uniqueness of
the inverse scattering problem (the problem of finding the potential with
respect to scattering operator) is studied.
Decoloniality in danger or being boosted? An exploration of ECOWAS positions and conflict management in the Western African region
Authors: Stoica Diana Sfetlana
Published: July 2023

This paper aims to explore the notion of decoloniality by examining the decisions and actions of the ECOWAS in response to the coup d’état in Burkina Faso in 2022, as well as other comparable sanctions imposed on Mali and Guinea during internal crisis challenges. These topics were raised and debated in various mass media outlets. For this purpose, readers are invited to imagine, based on ideas interpreted from official positions of the ECOWAS, or perceptions of them, expressed in academic narratives and the media, if decoloniality could be boosted or is in danger, following the decisions, actions, and positions of the ECOWAS. The interpretations through the lens of decoloniality portrayed in African narratives, and these explorations are characteristic of qualitative analysis. In examining how ECOWAS manages potential crises in the region, particularly in the cases of Guinea, Mali, and Burkina Faso, we can identify basic features of decoloniality. Taking a social-constructivist perspective, we can explore how African narratives of development can inspire critical resistance. Specifically, we must consider how power and relationships based on power can be decolonized to prioritize a people-centric view of development. In analyzing the use of violence and safety in the actions of the ECOWAS, we can determine whether they boost or endanger decoloniality. The academic community has shown considerable interest in the impact of the ECOWAS on the political climate of Western African states. However, it is important to consider the philosophical perspective on how the portrayal of ECOWAS actions and decisions can affect the narratives of opposition, anti-ism, and power dynamics. Specifically, in the case of internal conflicts, these portrayals can direct the debate on whether decolonization, as a theory, cultural movement, or process, can continue the work of African resistance initiated during the decolonization process which remains unfinished.
Radiografía de un pueblo minero, San Pedro de los Pozos Palmar de la Vega en 1743
Authors: Talavera Ibarra Oziel Ulises
Published: July 2023

En este artículo se analizan los datos de un padrón de Pozos, Guanajuato, de 1743, para conocer aspectos fundamentales de su sociedad, como la estructura por grupos de edad; se cruzó la información con bautizos y entierros para identificar la mortalidad, la natalidad y la fecundidad. Se midió la confiabilidad de la edad declarada con los índices de Whipple y de Myers. Se identificaron los tipos de hogares de acuerdo con la tipología de Laslett, además se discute la calidad reportada en los hogares y en los individuos. Se estudia el desarrollo poblacional desde sus primeros momentos y hasta el siglo XX, incluyendo un padrón de 1768. Se describe la relación entre población y actividades económicas, sobre todo con la minería.
Diana Hernández Suárez, Fin de siglo Porfirista: arte y política en la Revista Moderna (1898-1911)
Authors: Oropeza Sánchez Ángel
Published: July 2023

Reseña a: Diana Hernández Suárez, Fin de siglo Porfirista: arte y política en la Revista Moderna (1898-1911)
Deportación de una collera de apaches en la provincia de Coahuila
Authors: Amezcua García Mónica Samantha
Published: July 2023

La frontera norestense de la Nueva España estuvo conformada por diferentes naciones indias, a las que se añadieron nuevos grupos de indios de otras regiones. Esto ocasionó grandes tensiones en el territorio, lo cual produjo una guerra entre ambas sociedades. Las autoridades de la época consideraron diferentes mecanismos para coaccionar a los “indios enemigos” a través del poder del Estado y de su “monopolio de la violencia”. Para que estos individuos no regresaran con sus grupos y reiniciaran la guerra se utilizó la deportación. En el presente trabajo de corte cualitativo se analizarán algunas de las experiencias que vivieron los apaches en las colleras, principalmente en la provincia de Coahuila en el siglo XVIII.
Topofobia en tiempos epidémicos. Un ejercicio en torno a los imaginarios urbanos durante la epidemia de la fiebre amarilla en Buenos Aires, 1871
Authors: Guiastrennec Lucas
Published: July 2023

El presente artículo intenta aproximarse a la (re) construcción social del espacio urbano experimentado en la ciudad de Buenos Aires cuando asoló la epidemia de fiebre amarilla en 1871. Desde un enfoque interdisciplinario, se emplean las categorías analíticas de imaginarios urbanos, sujeto habitante, lugar, topofilia y topofobia, provenientes de la geografía humanística y de los estudios urbanos para explorar cómo se reconfiguró el espacio urbano durante la epidemia. Se analizan los imaginarios urbanos del espacio como peligroso, infecto y de miedo, por un lado, y en contrapartida, imaginarios del espacio como saludable y esperanzador. Para alcanzar dichos objetivos, el trabajo analiza un corpus documental diverso que abarca estadísticas, artículos periodísticos, tratados médicos, cartografías y autobiografía.
El Ferrocarril Interoceánico en la modernización del Sacromonte en Amecameca. Poder, infraestructura y transformación socioespacial
Authors: Hernández Flores Fabiola
Published: July 2023

El descarrilamiento del Ferrocarril Interoceánico en Temamatla se considera una de las grandes catástrofes decimonónicas en México debido a los numerosos peregrinos heridos. Sin embargo, desde la perspectiva urbana, el suceso se advierte parte de la transformación del Sacromonte en un lugar turístico. Este trabajo analiza los efectos urbanos del ferrocarril y la modernización del santuario en la ciudad de Amecameca de 1880 a 1900; este periodo comprende el inicio de operaciones del tren y las consecuencias del siniestro de Temamatla. El análisis abarca tres temas: las relaciones de poder entre el gobierno, el clero, y los terratenientes que impulsaron las peregrinaciones; la infraestructura construida para el turismo; y los cambios socioespaciales evidentes en el carnaval de Semana Santa.
Redundant Ballistic Chronograph Configuration for Body Armor Testing
Authors: Riley Michael , Barry Dwight , Paulter Nicholas G.
Published: July 2023

A new configuration of the light screen pairs used in a redundant ballistic chronograph is described. This configuration complies with current ASTM International and National Institute of Justice requirements for measuring the ballistic performance of body armor. Although it currently requires dismantling the commercially available light screens and installing them on custom-made mounting frames, the overall configuration is simpler to arrange and to obtain separation uncertainties than the conventional configuration that uses separate mounting frames.
Conhecimento popular e utilização das práticas integrativas e complementares na perspectiva das enfermeiras / Popular knowledge and use of integrative and complementary practices at the perspective of nurse
Authors: Martins Priscila Gomes , Brito Rubia Sousa , Matos dos Santos Pollyane da Costa , Laverde Carolina Rodrigues , De Oliveira Nunila Ferreira , Pilger Calíope
Published: July 2023

Objetivo: analisar o conhecimento dos enfermeiros da Atenção Primária em Saúde sobre as Práticas Integrativas e Complementares em saúde e sua utilização. Método: estudo descritivo, exploratório com abordagem qualitativa. As participantes foram 10 enfermeiras que trabalham em unidades básicas de saúde no interior de Goiás. A coleta de dados foi realizada por meio de entrevista semiestruturada, no período de agosto a dezembro de 2015. Para análise dos dados utilizou análise temática de Bardin. Resultados: as entrevistas evidenciaram a importância que as Práticas Integrativas e práticas populares em saúde exercem na comunidade, ressaltando o uso de plantas medicinais/fitoterapia e cromoterapia. Foi evidenciado que os idosos são os principais praticantes. Conclusões: percebeu-se que as enfermeiras conheciam algumas práticas, seus benefícios, obtiveram experiências advindas dos usuários, contudo, encontrou-se barreiras na comunicação e no vínculo, resultando na ausência de trocas de saberes das diferentes formas de fazer saúde.
Implantação da sistematização da assistência por enfermeiras na atenção básica: facilidades e dificuldades / Implementation of care systematization by nurses in primary care: facilities and difficulties
Authors: Santos Andressa Katiucia Oliveira , Sousa Mayanne Santos , Silva Andrey Ferreira da , Estrela Fernanda Matheus , Lima Nayara Silva , David Rose Ana Rios , Sousa Tamires Jesus , Oliveira Daniela Fagundes de
Published: July 2023

Objetivo: conhecer estratégias que facilitam e dificultam a implementação da Sistematização da Assistência de Enfermagem na Atenção Primária à Saúde. Método: revisão integrativa na Scientific Electronic Library Online e Biblioteca Virtual em Saúde, artigos publicados de 2015 a 2019, descritores em português e inglês: Enfermeiras e Enfermeiros, Atenção Primária à Saúde, Processo de Enfermagem. Realizou-se análise de conteúdo segundo técnica de Bardin. Resultados: 10 artigos analisados e duas categorias temáticas emergidas: “Dificuldades para implementação da Sistematização da Assistência de Enfermagem na Atenção Básica” versando sobre fatores que influenciam negativamente na aplicação do processo de enfermagem; e “Facilidades para implementação da Sistematização da Assistência de Enfermagem na Atenção Básica” abordando viabilidades no que se refere a organização/planejamento da equipe de enfermagem para tal conduta. Conclusão: há extrema relevância da implementação da Sistematização da Assistência de Enfermagem na Atenção Primária à Saúde, pois, promove melhor assistência ao usuário e autonomia do(a) enfermeiro(a).
Combination of Neutrophil Count and Gensini Score as a Prognostic Marker in Patients with ACS and Uncontrolled T2DM Undergoing PCI
Authors: Xu Yanyan , Qin Zhen , Gao Jiamin , Yang Yu , Lu Yongzheng , Yu Fengyi , Lv Yan , Sun Zhaowei , Zhang Jinying , Tang Junnan
Published: July 2023

Background: Several biomarkers have been studied as prognostic indicators among people with diabetes and coronary artery disease (CAD). The purpose of this study was to determine the prognostic value of neutrophil counts and the Gensini score in patients with diabetes and ACS undergoing percutaneous coronary intervention (PCI).

Methods: A total of 694 people with ACS and T2DM who simultaneously had elevated HBA1c received PCI. Spearman rank correlation estimates were used for correlation evaluation. Multivariate Cox regression and Kaplan-Meier analysis were used to identify characteristics associated with major adverse cardiovascular and cerebrovascular events (MACCEs) and patient survival. The effects of single- and multi-factor indices on MACCEs were evaluated through receiver operating characteristic curve analysis.

Results: The Gensini score and neutrophil count significantly differed between the MACCE and non-MACCE groups among patients receiving PCI who had concomitant ACS and T2DM with elevated HBA1c (P<0.001). The Gensini score and neutrophil count were strongly associated with MACCEs (log-rank, P<0.001). The Gensini score and neutrophil count, alone or in combination, were predictors of MACCEs, according to multivariate Cox regression analysis (adjusted hazard ratio [HR], 1.005; 95% confidence interval [CI], 1.002–1.008; P=0.002; adjusted HR, 1.512; 95% CI, 1.005–2.274; P=0.047, respectively). The Gensini score was strongly associated with neutrophil count (variance inflation factor ≥ 5). Area under the curve analysis revealed that the combination of multivariate factors predicted the occurrence of MACCEs better than any single variable.

Conclusion: In patients with T2DM and ACS with elevated HBA1c who underwent PCI, both the Gensini score and neutrophil count were independent predictors of outcomes. The combination of both predictors has a higher predictability.
Terminal differentiation of villus tip enterocytes is governed by distinct Tgfβ superfamily members
Authors: Berková Linda , Fazilaty Hassan , Yang Qiutan , Kubovčiak Jan , Stastna Monika , Hrckulak Dusan , Vojtechova Martina , Dalessi Tosca , Brügger Michael David , Hausmann George , Liberali Prisca , Korinek Vladimir , Basler Konrad , Valenta Tomas
Published: July 2023

The protective and absorptive functions of the intestinal epithelium rely on differentiated enterocytes in the villi. The differentiation of enterocytes is orchestrated by sub‐epithelial mesenchymal cells producing distinct ligands along the villus axis, in particular Bmps and Tgfβ. Here, we show that individual Bmp ligands and Tgfβ drive distinct enterocytic programs specific to villus zonation. Bmp4 is expressed from the centre to the upper part of the villus and activates preferentially genes connected to lipid uptake and metabolism. In contrast, Bmp2 is produced by villus tip mesenchymal cells and it influences the adhesive properties of villus tip epithelial cells and the expression of immunomodulators. Additionally, Tgfβ induces epithelial gene expression programs similar to those triggered by Bmp2. Bmp2‐driven villus tip program is activated by a canonical Bmp receptor type I/Smad‐dependent mechanism. Finally, we establish an organoid cultivation system that enriches villus tip enterocytes and thereby better mimics the cellular composition of the intestinal epithelium. Our data suggest that not only a Bmp gradient but also the activity of individual Bmp drives specific enterocytic programs.
TRIM71 reactivation enhances the mitotic and hair cell–forming potential of cochlear supporting cells
Authors: Li Xiao‐Jun , Morgan Charles , Nadar‐Ponniah Prathamesh T , Kolanus Waldemar , Doetzlhofer Angelika
Published: July 2023

Cochlear hair cell loss is a leading cause of deafness in humans. Neighboring supporting cells have some capacity to regenerate hair cells. However, their regenerative potential sharply declines as supporting cells undergo maturation (postnatal day 5 in mice). We recently reported that reactivation of the RNA‐binding protein LIN28B restores the hair cell–regenerative potential of P5 cochlear supporting cells. Here, we identify the LIN28B target Trim71 as a novel and equally potent enhancer of supporting cell plasticity. TRIM71 is a critical regulator of stem cell behavior and cell reprogramming; however, its role in cell regeneration is poorly understood. Employing an organoid‐based assay, we show that TRIM71 re‐expression increases the mitotic and hair cell–forming potential of P5 cochlear supporting cells by facilitating their de‐differentiation into progenitor‐like cells. Our mechanistic work indicates that TRIM71's RNA‐binding activity is essential for such ability, and our transcriptomic analysis identifies gene modules that are linked to TRIM71 and LIN28B‐mediated supporting cell reprogramming. Furthermore, our study uncovers that the TRIM71‐LIN28B target Hmga2 is essential for supporting cell self‐renewal and hair cell formation.
Contribution of the Professor Daniil M. Puchinyan to the hemostaseology challenges development
Authors: Ostrovskiy Vladimir V. , Ulyanov Vladimir Yu. , Grishin Sergey E. , Fedonnikov Alexander S. , Norkin Igor A.
Published: July 2023

This research follows the scientific career of Professor Daniil M. Puchinyan, who made a significant contribution to the development of Russian theoretical and practical hemostaseology. His name is associated with the designing of a new hemostaseology direction — adaptive (preventive) coagulology focused on considering the reserve capacities of hemostasis system in antithrombotic prophylaxis in patients at risk of postoperative thrombotic complications.
Edukasi Seks Berbasis Permainan Puzzle untuk Meningkatkan Keterampilan Perlindungan Diri Anak
Authors: Agustina Laelatus Syifa Sari , Kusumawati Rafika Nur , Hardjono Hardjono
Published: July 2023

Banyaknya kasus Kekerasan Seksual pada Anak (KSA) terjadi karena anak tidak memahami kejahatan seksual. Selain itu, anak tidak menyadari bahwa mereka adalah golongan yang rawan menjadi korban KSA. Di sisi lain, masih banyak orang tua yang kurang terampil memberikan pendidikan seks yang tepat pada anak, bahkan masih menganggapnya sebagai hal yang tabu. Untuk itu, peneliti mencoba membuat metode pembelajaran edukasi seks kepada anak melalui permainan puzzle. Pemberian pengetahuan dan keterampilan melalui metode permainan adalah cara yang sangat tepat bagi anak. Hal ini juga mempermudah orang tua atau guru untuk mengajarkan anak tentang perlindungan diri dalam edukasi seks. Tujuan penelitian ini adalah untuk mengetahui pengaruh permainan puzzle edukasi seks pada keterampilan perlindungan diri anak. Penelitian ini melibatkan 17 anak usia 5-6 tahun. Metode dilakukan dengan eksperimen one group pretest-posttest. Analisis dalam penelitian ini menggunakan paired sample t-test dengan bantuan program pengolah data, untuk menguji apakah terdapat perbedaan keterampilan perlindungan diri antara sebelum dan sesudah intervensi dilakukan pada sebuah kelompok eksperimen. Eksperimen dilakukan menjadi dua sesi pertemuan yang didampingi oleh fasilitator. Hasil menunjukkan terdapat perbedaan yang signifikan terhadap keterampilan perlindungan diri anak sebelum dan sesudah pemberian permainan puzzle seks edukasi dengan taraf signifikansi 0,000. Many cases of childhood sexual abuse occurred because children do not understand what sexual abuse is. Furthermore, children do not realize that they are a vulnerable group to become victims of childhood sexual abuse. On the other hand, there are still many parents who are not skilled enough to provide proper sex education to their children, and even consider it a taboo. For this reason, the researcher tried to make a method of learning sex education to make a method of learning sex education to children through puzzle games. Providing knowledge and skills to children through play methods is a very appropriate way for children about self-protection in sex education. The purpose of this study was to determine the effect of educational sex puzzle games on children’s self protection skills.  This study involved 17 children aged 5-6 years. The method was carried out by experimenting with one group pretest-posttest. The analysis in this study used a paired sample t-test with SPSS software, to test whether there were differences in self-protection skills between before and after the intervention was carried out in an experimental group. The experiment was carried out into two meeting sessions facilitated by the facilitator. The results showed that there were significant differences in children’s self-protection skills before and after giving the educational sex puzzle games with significant level at 0,000.
Bone metastases from differentiated thyroid cancer: characteristics and prognostic factors in a multicenter series
Authors: Piñar-Gutiérrez Ana , Romero-Lluch Ana R , Dueñas-Disotuar Suset , de Lara-Rodríguez Irene , Gálvez-Moreno María Ángeles , Martín-Hernández Tomás , García-Alemán Jorge , Martínez-de Pinillos Guillermo , Navarro-González Elena
Published: July 2023

Objective

The aim of this study is to describe the characteristics, survival and prognostic factors of a cohort of patients with bone metastases (BMs) from differentiated thyroid carcinoma (DTC).

Methods

This was a multicenter retrospective observational study including patients diagnosed with BMs from DTC between 1980 and 2021. A Cox regression was performed to study prognostic factors for 5- and 10-year survival. Kaplan–Meier and log-rank tests were performed for the survival analysis and comparison between groups.

Results

Sixty-three patients were evaluated. Median follow-up from BM diagnosis was 35 (15–68) months. About 30 (48.4%) patients presented with synchronous BMs. Regarding histology, 38 (60.3%) had the papillary variant. BMs were multiple in 32 (50.8%) patients. The most frequent location was the spine (60.3%). Other metastases were present in 77.8%, mainly pulmonary (69.8%). Concerning treatment, 54 (85.9%) patients received I131, with BM uptake in 31 (49.2%) and 25 (39.7%) received treatment with multikinase inhibitors. Regarding complications, 34 (54%) patients had skeletal-related events, 34 (54%) died and 5- and 10-year overall survival was 42.4% and 20.4%, respectively. Significant prognostic factors in the multivariate analysis were the presence of lymph node involvement (hazard ratio (HR): 2.916; 95% confidence interval (CI): 1.013–8.391; P = 0.047) and treatment with I131 (HR 0.214 (95% CI 0.069–0.665); P = 0.008) at 5 years, the presence of other metastases (HR 6.844. 95% CI 1.017–46.05; P = 0.048) and treatment with I131 (HR 0.23 (95% CI 0.058–0.913); P = 0.037) at 10 years.

Conclusions

Our study reflects the management of patients with bone metastases from differentiated thyroid carcinoma in real clinical practice in several centers in southern Spain. Overall survival at 5 and 10 years was lower in patients who were not treated with I131, had nodal involvement and/or had other metastases.
La caída de una camarera mayor
Authors: García Pérez Francisco José
Published: July 2023

Cada vez son más los estudios que centran su atención en el poder informal que se daba en espacios cortesanos aparentemente no ligados a los principales núcleos de poder político, como eran los consejos de la monarquía. En este sentido, el cuarto de la reina fue uno de esos espacios, por lo que tiene sentido pensar que los principales cargos que allí servían fuesen elegidos con extremo cuidado. Precisamente por eso, la camarera mayor, máximo puesto de gobierno dentro de la cámara de la reina, era cuidadosamente elegida. Este artículo persigue estudiar el caso atípico de la duquesa de Terranova, camarera mayor de María Luisa de Orleans, que fue despedida a los pocos meses de empezar sus funciones. A lo largo de estas líneas, se analizarán los diferentes intereses que hubo en su sustitución, así como las principales partes interesadas, que, al contrario de lo que tradicionalmente se ha defendido, iban mucho más allá de las preferencias de la reina María Luisa. Demostrando, de ese modo, que la colocación de una camarera mayor en el cuarto de la reina no se reducía nunca a simples asuntos domésticos de la corte.
Comunicar novedades, representar al patrón y disfrutar de mercedes. Los informadores del cardenal Francisco de Dietrichstein en Flandes
Authors: Nováková Anna
Published: July 2023

El objetivo principal de este trabajo es estudiar el papel de las relaciones clientelares en el proceso de la comunicación política y cultural entre la corte de Bruselas y el Reino de Bohemia en la época de la guerra de los Treinta Años. A través del epistolario del cardenal Francisco de Dietrichstein, conservado en el Archivo Regional de Moravia en Brno, analizaremos las actividades desarrolladas por sus informadores de la zona de Flandes: Guillermo Verdugo y Martin Somogyi. Mientras que el primer mencionado, coronel del ejército español y gobernador del Palatinado Renano, informaba a Dietrichstein sobre los asuntos de guerra, el barón Somogyi era miembro de la casa del archiduque Alberto y servía a Dietrichstein como defensor de sus intereses particulares en la corte archiducal. De este modo, se inscribe dentro de una reciente línea de investigación historiográfica sobre la corte, el fenómeno de los agentes y las redes clientelares.
“Per la conservasion di questa piazza”: Arab Ahmed Pasha y las múltiples visiones de Argel en el Mediterráneo después de Lepanto (1572-74)
Authors: Caprioli Francesco
Published: July 2023

Durante su gobierno argelino (1572-74), Arab Ahmed Pasha mantuvo una intensa correspondencia con la corona francesa. En una de las cartas que dirigió a Carlos IX, el gobernador otomano pidió a los Valois que intercedieran en su favor ante el sultán Selim II para defenderse de las acusaciones de mal gobierno formuladas por Arnaud Mami, a la sazón jefe almirante de los corsarios argelinos. Sin embargo, el apoyo francés no pudo evitar que la Sublime Puerta decidiera destituir a Arab Ahmed de su cargo y nombrar a su sucesor para administrar la provincia de Argel. Siguiendo los hilos de esta historia desde tres puntos de vista diferentes (francés, otomano y argelino), este artículo trata de explorar las distintas funciones desempeñadas por la ciudad de Argel en el Mediterráneo después de Lepanto. Junto a las funciones clásicas de Argel como gran centro corsario y primera provincia otomana en el norte de África, esta investigación subraya también la presencia de una política privada decidida por el gobernador local y no siempre en consonancia con la de los sultanes de Estambul o con la de los principales actores del contexto argelino.
Models of the Mediterranean, Camocio’s Isolario, and Early Modern Showings and Tellings in light of Lepanto
Authors: Brummett Palmira
Published: July 2023

This essay proposes three models of Mediterranean space and action that emerge out of early modern narratives and visuals (particularly maps). These overlapping models, for the long sixteenth century, are: 1) itinerary; 2) empire; and 3) predator, all of which appear under the broader frame of geographic-commercial space that is either conflicted or pacific. I employ a preliminary narrative, The Deeds of Commander Pietro Mocenigo, by Coriolano Cippico, a galley commander in the Ottoman-Venetian conflict of 1470-1474; then, the isolario of Giovanni Camocio, as it appeared in the aftermath of the Battle of Lepanto in 1571. Camocio’s maps focus attention on that battle and on imperial conflict. But his vision of the Mediterranean is that of a range of familiar, maritime spaces dotted with fortresses and harbors, sometimes enmeshed in conflict and more often not.
Frecuencia de hospitalizaciones por síndrome urémico hemolítico en niños de 0 a 14 años en el Perú, periodo 2015 a 2022
Authors: Atamari-Anahui Noé , Cabello-Coca Stephanie , Alvarado-Gamarra Giancarlo , Apeña-Cabrera Carla Lisette
Published: July 2023

Introducción. Existen limitados reportes epidemiológicos del síndrome urémico hemolítico (SUH) en Latinoamérica. Objetivo. Describir la frecuencia y características de las hospitalizaciones por SUH en niños de 0 a 14 años. Métodos. Se realizó un estudio descriptivo de análisis secundario con datos de hospitalizaciones por SUH de instituciones de salud de Perú en el periodo 2015-2022. Resultados. Se registraron 228 hospitalizaciones. El 52,2% fueron varones. El 88,6% fue menor de cinco años y el 11% menor de un año. Los departamentos con más hospitalizaciones fueron Lima y Arequipa con 133 y 46 casos. Las instituciones del Ministerio de Salud (MINSA) y del Seguro Social (EsSalud) reportaron el 42,5% y 27,6% de las hospitalizaciones. Del 2015 al 2022, la incidencia varió de 0,42 a 1,13 casos/100 000 niños menores de cinco años. Conclusiones. Las hospitalizaciones por SUH fueron más frecuentes en menores de cinco años y en las instituciones del MINSA.
Prevalencia de Giardia lamblia por ecorregiones en preescolares y escolares peruanos: Propuesta de estratificación de riesgo
Authors: Cabrera Rufino , Whittembury Alvaro , Terashima Angélica
Published: July 2023

Introducción. La giardiasis es ocasionada por el protozoario intestinal Giardia lamblia, su transmisión tiene variabilidad geográfica y a pesar de ser muy frecuente, no existe una herramienta de estratificación de riesgo para priorizar las intervenciones. Objetivo. Estimar la prevalencia de G. Lamblia en preescolares y escolares peruanos por ecorregiones entre 1990 a 2018. Métodos. A partir de un metaanálisis previo, se realizó un subanálisis por ecorregiones de la prevalencia de G. lamblia en 26 estudios en preescolares y escolares peruanos entre 1990 a 2018. Se extrajeron los datos por distrito y utilizando Google Earth fueron clasificados en ecorregiones. La heterogeneidad fue analizada mediante la prueba de Q de Cochrane y el sesgo de publicación mediante el método de Egger con StatsDirect versión 3.2.7. Se utilizó el método de riesgo absoluto para estratificar la prevalencia a nivel de distrito y se definió 4 estratos en base a los percentiles o arbitrariamente. Resultados. Se identificaron 43 datos de prevalencia a nivel de distrito que incluyeron 7606 participantes. Las prevalencias combinadas más altas por el método de efectos aleatorios de G. lamblia fueron de 47,0% (intervalo de confianza (IC) 95%: 40,0 -54,0) en el desierto del Pacífico; 27,9% (IC95%: 22,8 - 33,2) en selva baja y 26,9% (IC95%: 22,5 - 31,5) en la Puna. Conclusiones. De cada 100 preescolares y escolares que viven en las ecorregiones del desierto del Pacífico, selva baja y Puna, 47, 28 y 27 menores de edad, respectivamente, están infectados con G. lamblia. Asimismo, se propone 4 estratos de riesgo en función de la prevalencia: esporádico (0 a <1%), hipoendémico (1 a <25%), mesoendémico (≥25 a <50%) e hiperendémico (≥50%).
Aportes sobre los mecanismos de deformación en las rocas sedimentarias de la Formación Cachíos, Yura, región de Arequipa
Authors: Vivanco Leguia Rosa Liliana , Alba Peña Robert Spier , Hurtado Enriquez Christian Augusto , Alvan De la Cruz Aldo Alfonso
Published: July 2023

La Formación Cachíos de la Cuenca sedimentaria Arequipa es la unidad litoestratigráfica más distinguible del Grupo Yura, debido a sus atributos litológicos y sus inusuales características deformacionales. La Fm. Cachíos (± 603 m) se compone de una intercalación de limolitas y arcillitas de grano muy fino, todas de coloración negra a gris muy oscuro, y representadas por las facies Fl de A. Miall. Es común encontrar como intercalaciones algunos estratos delgados (<0.5 m) de areniscas cuarzosas gris verdosas, y eventuales estratos más gruesos (de hasta ca. 12 m) del mismo material litológico deformado como olistolitos. Tales estructuras se encuentran frecuentemente con flexuras, eventuales pliegues, slumps, fallas normales sin sedimentarias, y con eventuales diques siliciclásticos, los cuales reflejan un proceso continuo de deformación. Tal asociación de características es distinguible para la Fm. Cachíos, y es atribuible muy probablemente a su composición litológica. La presente investigación, plantea reportar, con aumento de detalle, el cartografiado de tales deformaciones, refinar el espesor estratigráfico, y explicar secuencialmente la geodinámica contemporánea al Calloviano en esta parte de la Cuenca Arequipa.
Evaluación del reaprovechamiento de los residuos sólidos orgánicos generados por los servicios de un catering
Authors: Castillo Zavaleta Carlos Orlando , Del Valle Jurado Carlos
Published: July 2023

El presente artículo tiene como finalidad comparar alternativas de reaprovechamiento de residuos sólidos orgánicos generados por los servicios de un catering, esta investigación se realizará mediante la verificación de estudios de no mayor a 5 años de antigüedad a la fecha actual, denotando sus avances en cada método a utilizar, mediante la comparación de métodos y resultados de cada estudio, para poder deslindar la mejor alternativa de reaprovechamiento, teniendo en cuenta el costo beneficio, las ventajas, desventajas y la viabilidad de cada estudio. Por lo cual en la presente investigación se tuvo como resultado optar por el reaprovechamiento de compostaje, debido a que es un proceso que genera grandes ganancias a poco costo, en lo general se reaprovecha un 80% de los residuos orgánicos, por otro lado, tenemos el aprovechamiento mediante la generación de energía mediante la obtención de biogás, siendo un proceso un poco más complicado debido a la mayor incidencia en costo/beneficio de esta alternativa de reaprovechamiento. Por ende, el artículo concluye en que estos 2 procesos de reaprovechamiento son efectivos, claro uno más económico y sencillo que el otro, pero destacando que ambos generan beneficios económicos.
Percepción de metodologías colaborativas en obras públicas en la Municipalidad Provincial de Puno
Authors: Huaricallo Vilca Yvan
Published: July 2023

Esta investigación busca determinar la percepción de metodologías colaborativas en la Municipalidad Provincial de Puno para garantizar una adecuada inversión pública. Se utilizó una encuesta como instrumento para medir la percepción de los niveles de conocimiento de metodologías colaborativas. Los funcionarios y servidores públicos involucrados en el diseño, ejecución y supervisión de obras fueron el público objetivo. Se determinó que todas las obras ejecutadas en el periodo 2017-2021 presentan ampliaciones de plazo, pero no todas las obras tienen adicionales de obra.La percepción del conocimiento y utilización de softwares colaborativos es alta en funcionarios y servidores públicos involucrados en proyectos de inversión.Se percibe una comunicación baja entre las oficinas de diseño, ejecución y supervisión; este problema recurrente se debe a que todo funcionario no quiere asumir más trabajo de lo que ya tiene, los trabajadores municipales se basan en los instrumentos de gestión municipal como el MOF y ROF.