bluuebunny/crossref_metadata_2025 huggingface dataset:
Response Analysis of the Three-Degree-of-Freedom Vibroimpact System with an Uncertain Parameter
Authors: Yang Guidong , Deng Zichen , Du Lin , Lin Zicheng
Published: September 2023

The inherent non-smoothness of the vibroimpact system leads to complex behaviors and a strong sensitivity to parameter changes. Unfortunately, uncertainties and errors in system parameters are inevitable in mechanical engineering. Therefore, investigations of dynamical behaviors for vibroimpact systems with stochastic parameters are highly essential. The present study aims to analyze the dynamical characteristics of the three-degree-of-freedom vibroimpact system with an uncertain parameter by means of the Chebyshev polynomial approximation method. Specifically, the vibroimpact system model considered is one with unilateral constraint. Firstly, the three-degree-of-freedom vibroimpact system with an uncertain parameter is transformed into an equivalent deterministic form using the Chebyshev orthogonal approximation. Then, the ensemble means responses of the stochastic vibroimpact system are derived. Numerical simulations are performed to verify the effectiveness of the approximation method. Furthermore, the periodic and chaos motions under different system parameters are investigated, and the bifurcations of the vibroimpact system are analyzed with the Poincaré map. The results demonstrate that both the restitution coefficient and the random factor can induce the appearance of the periodic bifurcation. It is worth noting that the bifurcations fundamentally differ between the stochastic and deterministic systems. The former has a bifurcation interval, while the latter occurs at a critical point.
Application of Circular Thermoeconomics to the Diagnosis of Energy Systems
Authors: Valero Antonio , Torres César
Published: September 2023

This paper reviews the fundamentals of the thermoeconomic diagnosis theory. Thermoeconomic diagnosis is one of the main applications of the exergy cost theory used to identify the causes of additional resource consumption of a system due to inefficiencies in its components, published in the late 1990s. Thermoeconomic diagnosis has usually been applied to diagnose power plants with high consumption of fossil fuels and fixed production. However, it does not consider the final production and waste generation variation. In this paper, Circular Thermoeconomics is applied to analyze in depth the effect of malfunctions on additional waste generation and changes in the final output of the system. This new formulation can be applied to polygeneration systems, where there is a simultaneous variation of final products, and to process integration and industrial symbiosis, where a part of the waste generated by a plant could be reused in other processes or plants.
Investigating the Ignition and Stability Limits of Premixed Methane/Air Combustion in Micro-Channels
Authors: Kutkut Almoutazbellah , Ayoobi Mohsen , Baumgardner Marc E. , Akkerman V’yacheslav
Published: September 2023

Understanding and improving the performance of miniature devices powered by micro-combustion have been the focus of continued attention of researchers recently. The goal of the present work is to investigate the behavior of premixed methane–air combustion in a quartz microreactor with an externally controlled wall temperature. Specifically, the impacts of the flow inlet velocity, the equivalence ratio, and the microreactor channel size are examined. This study is conducted by means of computational simulations, and the results are validated against prior experimental data, as well as by other similar studies in the literature. Utilizing simulation results with detailed chemistry, the present work provides more in-depth insight into a variety of phenomena, such as ignition, flame propagation, flames with repetitive extinctions and ignitions (FREI), and flame stabilization. In particular, the ignition, the flame span, and the FREI-related characteristics are scrutinized to understand the underlying physics of the flame stability/instability modes. It is shown that the flames appear stable at higher inlet velocities, while the FREI mode is detected at a lower inlet velocity, depending on the equivalence ratio and the channel size. The findings also explain how different operating conditions impact the flame characteristics in both stability modes.
New Renewable Hydrothermal Liquefaction (HTL) Biofuel: A Combustion and Emissions Study in an Optical Engine
Authors: Khare Shivang , Bjørgen Karl Oskar Pires , Kohansal Komeil , Haider Muhammad Salman , Castello Daniele , Pedersen Thomas Helmer , Løvås Terese , Emberson David Robert
Published: September 2023

This study involves the investigation of municipal solid waste (MSW) based biofuel in order to demonstrate its utilization as a diesel blendstock in a compression ignition (CI) engine. The biofuel was produced from the Hydrothermal Liquefaction (HTL) process. The tested biofuels represented both distilled (known as nonupgraded HTL biofuel) and hydrotreated (known as upgraded HTL biofuel) fuels, obtained from raw bio-crude. The effects of the HTL biofuel and diesel blending on the combustion and emission characteristics were investigated. A comparative study of nonupgraded and upgraded HTL biofuel in terms of combustion and emissions was conducted. The upgraded HTL biofuel was blended with reference diesel (RD) by 5%, 10%, and 40% by weight, respectively, and the nonupgraded HTL biofuel was blended with RD by 10% by weight. The experiments were conducted in an optically accessible compression ignition chamber (OACIC) with engine-like thermodynamic conditions. The parameters were recorded at a constant speed and at fixed thermodynamic conditions. The heat release rate (HRR), in-cylinder pressure, ignition delay (ID), flame lift-off length (FLOL), and in-flame soot were measured. The PM, CO, NOx, and CO2 were also recorded. In summary, the HTL blends exhibited a close resemblance to the reference diesel across a range of combustion parameters and regulated emissions. Furthermore, the upgraded HTL blends outperformed the nonupgraded blend in terms of both combustion characteristics and emissions.
Design of Planar Transformers for LLC Converters in High Power Density On-Board Chargers for Electric Vehicles
Authors: Son Won-Jin , Lee Byoung Kuk
Published: September 2023

This article presents a planar transformer design and optimization method for high power density on-board chargers (OBCs) utilized in electric vehicles (EVs). Owing to considerations of electrical safety, OBCs require an isolated converter, leading to a substantial increase in volume due to the inclusion of a transformer. To address this issue and achieve high power density, a planar transformer is used, and an optimized design method is proposed for pattern arrangement, width, and core shape. The feasibility of the design is verified through the development of a 3.3 kW OBC prototype. Consequently, when compared to conventional transformers, the design method in this article results in a 27% reduction in the transformer’s height and a 20% reduction in its overall volume. This reduction is advantageous for meeting the requirements of high power density OBCs.
Day-Ahead Bidding Strategy of a Virtual Power Plant with Multi-Level Electric Energy Interaction in China
Authors: Sun Hui , Dou Yanan , Hu Shubo , Gao Zhengnan , Wang Zhonghui , Yuan Peng
Published: September 2023

Effective aggregation and rational allocation of flexible resources are the fundamental methods for solving the problem of an insufficient flexibility adjustment ability of a power system. The flexible scheduling resources of a distribution system are often small in scale and distributed mostly by different stakeholders. A virtual power plant (VPP) gathers small resources to participate in the day-ahead electricity market, but, due to the scale and characteristics of a VPP’s internal flexible resources, it cannot reach the access threshold of a peak shaving market in some periods due to small differences. In order to solve the market bidding problem of a VPP limited by capacity, and to achieve economic goals, a virtual power plant operator (VPPO) not only needs to interact with internal subjects but also needs to interact with other subjects with flexible resources in the distribution network. In this study, an electric vehicle (EV) cluster is taken as the interactive object, and a day-ahead bidding strategy of a VPP with multi-level electric energy interaction is proposed. The VPP not only makes full-time game pricing for internal participants but also makes time-sharing bargaining with an EV operator. The validity and the rationality of the proposed strategy are verified by an example.
Distributed Reactive Power Injection-Based Approach for Minimization of Losses in Electrical Networks Considering Heuristic Algorithms and Voltage Deviation
Authors: Filho Gilberto Lopes , Corrêa Henrique Pires , Vieira Flávio Henrique Teles
Published: September 2023

This paper deals with the reduction in electrical losses and the minimization of voltage deviation in electrical power grids. To this end, a novel heuristic-based approach is proposed for controlling reactive power injections along an electrical grid with distributed generation using distributed photovoltaic (PV) generation. The proposed approach consists of applying a heuristic, namely a genetic or firefly algorithm, to solve the loss and voltage deviation optimization problem by controlling PV reactive power injections. The proposed method was tested on a radial 100-bus network with an intense penetration of PV generation. The obtained results indicate that the proposed method consistently yields superior grid performance when compared to algorithms previously proposed in the literature. In fact, it led to a reduction in the active power supplied by the reference bus to the grid, thereby alleviating the burden imposed on the most upstream parts of the distribution network. As a consequence, the proposed method contributes to a power-efficient network, enhancing its loss performance and voltage stability.
Policy Design for Electricity Efficiency: A Case Study of Bottom-Up Energy Modeling in the Residential Sector and Buildings
Authors: Sanchez-Escobar Marlene Ofelia , Noguez Julieta , Molina-Espinosa Jose Martin , Escobar-Castillejos David , Ruiz-Loza Sergio
Published: September 2023

Energy models play a crucial role in the domain of energy policy by serving as essential instruments for decision-making. However, a significant limitation of numerous bottom-up energy models (BUEMs) is their empirical design, which hinders their ability to effectively inform policy design. This study presents a structured framework that can be used to improve the effectiveness of behavior, understanding, and engagement measures in the development of BUEMs for enhancing energy end-use efficiency. The model selected for this case study was provided by the Mexican Commission for the Efficient Use of Energy (CONUEE), and it examines the impact of regulatory instruments on the residential sector and residential buildings. The benefits of the proposed framework were successfully demonstrated through a quantitative comparison of real energy models, using and without using the said framework, revealing the advantages of its use. The framework significantly decreases the time required for model generation in various aspects by 59.43%. The obtained results highlight the effectiveness of the framework, and it could enhance the existing knowledge in the sector.
Heat Budget of Sub-Mediterranean Downy Oak Landscapes of Southeastern Crimea
Authors: Safonova Mariia , Tabunshchik Vladimir , Gorbunov Roman , Gorbunova Tatiana
Published: September 2023

This article presents the findings of a research endeavor focused on the diurnal and seasonal dynamics of heat balance and its constituent elements within an oak forest situated in the expanse of the Karadag Nature Reserve. Computed are the values corresponding to the elements of heat balance, encompassing radiation balance, latent heat fluxes corresponding to heat consumption for evaporation, turbulent heat exchange transpiring within the atmosphere, and heat flux coursing through the soil. The features of changes in the heat balance in two key areas are considered: in the zone of growth of the downy oak forest in an open area and in the forest itself. The study discloses patterns characterizing the apportionment of radiation balance into heat and energetic fluxes within the context of the downy oak landscapes native to the southeastern Crimea. Scrutiny of the data established that a substantial proportion of radiation balance finds application in propelling turbulent heat flux, while a minor share is channeled into processes of evaporation and soil heat flux. Evidenced is that the magnitudes of heat balance components, encompassing radiation balance, latent heat fluxes corresponding to heat consumption for evaporation, turbulent heat exchange transpiring within the atmosphere, and heat flux through the soil within the sub-canopy realm, undergo modifications contingent upon the seasons of the year and the vegetative phases of the downy oak forest. The correlation between air temperature and the constituents of heat balance is subject to analysis both within the confines of the territory in the zone of growth of the downy oak forest in an open area and in the forest itself. Manifest is the constancy of the influence exerted by forest vegetation upon heat balance; nevertheless, the degree of its impact is circumscribed by the cyclical dynamics of foliage upon the trees: a well-developed canopy serves to amplify the influence exerted upon the distribution of heat and energetic fluxes. This study of heat balance and its constituents assumes significance in engendering comprehension regarding the operation of downy oak landscapes that are situated on the periphery of their habitudinal range. Also, it helps to reveal deeper patterns of climate change in forest ecosystems.
Seed Dormancy Characteristics of Kadsura coccinea (Lem.) A. C. Smith, a Unique Medicinal Plant in Southeast Asia
Authors: He Tieding , Zhong Wenbin , Shao Fengxia , Guo Hongyan , Yan Chao , Ge Xiaoning , Wang Jia , Wang Sen
Published: September 2023

Kadsura coccinea (Lem.) A. C. Smith is a significant tree species of non-timber forest. However, the low germination percentage and lengthy germination time of its seeds pose obstacles to industry development. Aiming at the problem of seed dormancy, this study first determined the seed dormancy period through seed germination test, and then comprehensively evaluated the dormancy characteristics by observing the seed coat structure, measuring endogenous inhibitors, and in vitro embryo culture. The results indicated the dormancy of K. coccinea seeds, and that the germination period was up to 80 days. Its seed coat is composed of exotesta and endotesta. The dense seed coat structure causes water absorption and air permeability obstacles to the seeds and causes mechanical restraint to the development of the embryo. Meanwhile, its seeds have substances that inhibit seed germination, and there are germination inhibitors in distilled water, methanol, petroleum ether, and ethyl acetate extracts of kernels and seed coats. The inhibitory activity of kernel petroleum ether extract was the highest, and the inhibitory activity of seed coat methanol extract was the highest. In addition, the embryo of K. coccinea developed completely and could germinate normally under in vitro conditions. This study has basically proved that the dormancy of K. coccinea seeds is caused by the seed coat (physical dormancy) and endogenous inhibitors (physiological dormancy), which provides a scientific theoretical basis to further explore the method of seed dormancy release of K. coccinea.
Vernal Pool Amphibian Inventories in the Temperate Forests of Eastern North America: Can Environmental DNA Replace the Traditional Methods?
Authors: Postaire Bautisse , Dupuch Angélique , Ladent Emilie , Surget-Groba Yann
Published: September 2023

Amphibian populations have been globally declining since at least 1990. In the temperate forests of eastern North America, vernal pools offer important breeding habitats to many amphibians but are usually not considered for forest management because of their small size and temporary status. The effective monitoring and management of amphibians rely on accurate knowledge of their spatiotemporal distributions, which is often expensive to collect due to the amount of fieldwork required. In this study, we tested whether eDNA metabarcoding could identify the same amphibian communities as the traditional inventory protocols. We collected eDNA samples in twelve vernal pools in the spring of 2019 and identified their communities via metabarcoding. At each pool, three traditional amphibian inventory methods were used: call surveys, trapping, and active search surveys. In total, 13 amphibian species were detected, with most of them being detected using both eDNA and the traditional methods. When comparing the results of eDNA with the traditional methods, we found that species ecology and behavior are key factors of its detectability via a specific method. With its higher taxonomical precision and repeatability, eDNA metabarcoding allows for the inventorying of amphibian species living and reproducing in vernal pools and their vicinity with accuracy. As eDNA metabarcoding is inexpensive compared to the traditional methods, we conclude that eDNA sampling should be considered for integration as a standard monitoring tool, after an initial assessment of amphibian diversity.
Species Composition and Diversity of Plants along Human-Induced Disturbances in Tropical Moist Sal Forests of Eastern Ghats, India
Authors: Behera Madhab Chandra , Sahoo Uttam Kumar , Mohanty Tanmay Lalitendu , Prus Piotr , Smuleac Laura , Pascalau Raul
Published: September 2023

Plant biodiversity data are prerequisites for the sustainable management of a forest. We used quantitative ecological tools to determine the species composition, diversity (richness and evenness), population structure, distribution patterns, and regeneration status of trees in a Tropical Moist Sal Forest of Eastern Ghats, India. For this purpose, a field inventory was conducted during 2020–2022 in sixteen 1.0 ha forest stands along a human-induced disturbance gradient. A total of 161 species (61 trees, 40 shrubs, 60 herbs) belonging to 77 families and 143 genera were recorded in the 16.0 ha of forest area. The results revealed a significant (p < 0.01) decrease in the tree and shrub species density, basal area, species richness, and diversity along the gradient of disturbance. However, in the case of herbs, the Shannon–Weiner diversity index increased significantly (p < 0.01) with increasing disturbance levels. Irrespective of forest types and disturbance levels, the tree diameter class (10–30 cm) accounted for the highest stem density in the forest. A mixed trend was found in the case of the basal area; the >41 cm diameter class constituted the highest basal area in the Pure Sal Forest while the 10–30 cm class was in the Moist Deciduous Forest without Sal. Tree species richness was found higher in lower diameter classes. Disturbances impacted the distribution pattern of trees; in the Pure Sal Forest, the contagious distribution of trees were 61.54%, 40%, and 12.5% in undisturbed, low-disturbed, and moderately disturbed sites, respectively. The percent of trees showing random and regular distribution increased with the increased level of disturbance in all forest types. The number of tree species having good regeneration decreased with the increased disturbance intensity in all forest types. Frequent grazing, repeated forest fires, and poor soil seed banks at the Moderately Disturbed site were the main reasons for the poor/no regeneration of Pterocarpus marsupium, Adina cordifolia, Terminalia bellerica, and some other economical species. Significant changes in structural attributes of the tree community revealed the impact of human-induced disturbances in the Moist Sal Forests of Eastern Ghats. The disturbance mosaics promoted the growth of many invasive weed species and lianas, depleting the number of valuable species in the forest. This study suggests the adaption of sustainable biodiversity conservation approaches through the active participation of the tribal so that the remnants the Moist Sal Forests of Eastern Ghats can be controlled to prevent further degradation.
From Free Tissue Transfer to Hydrogels: A Brief Review of the Application of the Periosteum in Bone Regeneration
Authors: Xin Hai , Tomaskovic-Crook Eva , Al Maruf D S Abdullah , Cheng Kai , Wykes James , Manzie Timothy G. H. , Wise Steven G. , Crook Jeremy M. , Clark Jonathan R.
Published: September 2023

The periosteum is a thin layer of connective tissue covering bone. It is an essential component for bone development and fracture healing. There has been considerable research exploring the application of the periosteum in bone regeneration since the 19th century. An increasing number of studies are focusing on periosteal progenitor cells found within the periosteum and the use of hydrogels as scaffold materials for periosteum engineering and guided bone development. Here, we provide an overview of the research investigating the use of the periosteum for bone repair, with consideration given to the anatomy and function of the periosteum, the importance of the cambium layer, the culture of periosteal progenitor cells, periosteum-induced ossification, periosteal perfusion, periosteum engineering, scaffold vascularization, and hydrogel-based synthetic periostea.
Lost in Translation? Agency and Incommensurability in the Transnational Travelling of Discourses of Sexualized Harm
Authors: Crosby Alison
Published: September 2023

This article argues for incommensurability, incoherence, and difference as the grounds through which to think about sexualized harm and its redress. It seeks to remove the “me” from the “too”, and to instead consider the structures of white supremacy and neocolonial power that have facilitated white Western feminists’ ability to participate in shaping a hegemonic discourse of sexualized harm and its transnational travelling. The article traces the author’s personal genealogy of rights work in the context of shifts in international jurisprudence in relation to wartime sexualized violence. It looks back and reflects on an eight-year feminist participatory action research project that accompanied 54 Mayan women protagonists who survived a multiplicity of harm, including sexual violence, during Guatemala’s 36-year genocidal war. The project documented the protagonists’ engagement with transitional justice mechanisms, including a paradigmatic court case and a national reparations program, as part of their struggles for redress. The concept of “protagonism” is used to understand agency in the aftermath of genocidal violence as relational, co-constructed, and imbued with power. The meaning of sexualized harm is always “in-translation” between Western and Mayan onto-epistemological positionings, as Mayan women seek to suture land-body-territory in their multifaceted strategies for redress that engage but always exceed rights regimes.
The Chloroplast Genome of Endive (Cichorium endivia L.): Cultivar Structural Variants and Transcriptome Responses to Stress Due to Rain Extreme Events
Authors: Testone Giulio , Lamprillo Michele , Gonnella Maria , Arnesi Giuseppe , Sobolev Anatoly Petrovich , Aiese Cigliano Riccardo , Giannino Donato
Published: September 2023

The chloroplast (cp) genome diversity has been used in phylogeny studies, breeding, and variety protection, and its expression has been shown to play a role in stress response. Smooth- and curly-leafed endives (Cichorium endivia var. latifolium and var. crispum) are of nutritional and economic importance and are the target of ever-changing breeding programmes. A reference cp genome sequence was assembled and annotated (cultivar ‘Confiance’), which was 152,809 base pairs long, organized into the angiosperm-typical quadripartite structure, harboring two inverted repeats separated by the large- and short- single copy regions. The annotation included 136 genes, 90 protein-coding genes, 38 transfer, and 8 ribosomal RNAs and the sequence generated a distinct phyletic group within Asteraceae with the well-separated C. endivia and intybus species. SSR variants within the reference genome were mostly of tri-nucleotide type, and the cytosine to uracil (C/U) RNA editing recurred. The cp genome was nearly fully transcribed, hence sequence polymorphism was investigated by RNA-Seq of seven cultivars, and the SNP number was higher in smooth- than curly-leafed ones. All cultivars maintained C/U changes in identical positions, suggesting that RNA editing patterns were conserved; most cultivars shared SNPs of moderate impact on protein changes in the ndhD, ndhA, and psbF genes, suggesting that their variability may have a potential role in adaptive response. The cp transcriptome expression was investigated in leaves of plants affected by pre-harvest rainfall and rainfall excess plus waterlogging events characterized by production loss, compared to those of a cycle not affected by extreme rainfall. Overall, the analyses evidenced stress- and cultivar-specific responses, and further revealed that genes of the Cytochrome b6/f, and PSI-PSII systems were commonly affected and likely to be among major targets of extreme rain-related stress.
Exome-Wide Association Study Identified Clusters of Pleiotropic Genetic Associations with Alzheimer’s Disease and Thirteen Cardiovascular Traits
Authors: Loika Yury , Loiko Elena , Culminskaya Irina , Kulminski Alexander M.
Published: September 2023

Alzheimer’s disease (AD) and cardiovascular traits might share underlying causes. We sought to identify clusters of cardiovascular traits that share genetic factors with AD. We conducted a univariate exome-wide association study and pair-wise pleiotropic analysis focused on AD and 16 cardiovascular traits—6 diseases and 10 cardio-metabolic risk factors—for 188,260 UK biobank participants. Our analysis pinpointed nine genetic markers in the APOE gene region and four loci mapped to the CDK11, OBP2B, TPM1, and SMARCA4 genes, which demonstrated associations with AD at p ≤ 5 × 10−4 and pleiotropic associations at p ≤ 5 × 10−8. Using hierarchical cluster analysis, we grouped the phenotypes from these pleiotropic associations into seven clusters. Lipids were divided into three clusters: low-density lipoprotein and total cholesterol, high-density lipoprotein cholesterol, and triglycerides. This split might differentiate the lipid-related mechanisms of AD. The clustering of body mass index (BMI) with weight but not height indicates that weight defines BMI-AD pleiotropy. The remaining two clusters included (i) coronary heart disease and myocardial infarction; and (ii) hypertension, diabetes mellitus (DM), systolic and diastolic blood pressure. We found that all AD protective alleles were associated with larger weight and higher DM risk. Three of the four (75%) clusters of traits, which were significantly correlated with AD, demonstrated antagonistic genetic heterogeneity, characterized by different directions of the genetic associations and trait correlations. Our findings suggest that shared genetic factors between AD and cardiovascular traits mostly affect them in an antagonistic manner.
Observational Prospective Study to Determine the Efficacy of ‘Non-Slip Socks’ vs. ‘Adequate Footwear’ Regarding the Number of Falls Observed among Admitted Patients
Authors: Moreno Rodríguez Rosa M. , Solas Gómez Beatriz , Gallego Marcuello Laura , Diaz Martinez Maria del Carmen , Fernández del Palacio Encarnacion , Santiago-Sáez Andrés
Published: September 2023

Background: Fall prevention is an important indicator of the quality of patient care. Prevention includes the use of adequate footwear. Our objective is to determine the differences in the number of falls between patients with “adequate footwear” and “non slip socks”, and their associated consequences, to support their use in the prevention of falls among hospitalized patients. Methods: This is an observational prospective study on inpatient falls. Patient characteristics, fall circumstances, and injuries were collected through Clinical Report Forms, a review of fall reports, and medical records. Admitted patients over 18 years old were recruited from Geriatric and Internal Medicine Units over a brief period of 3 months. Results: A total of 158 hospitalized patients were recruited. In total, 77 patients (48.73%) were assigned to the non-slip socks group, and 81 (51.27%) were assigned to the adequate footwear group. There were 21 falls during the study period, all of which were experienced by the adequate footwear group (p < 0.0001). The mean age of the patients who fell was 83.14 (range 60–100) years old. The most frequent reasons for admission among the patients who fell were COVID-19 infection (19%) and oncological complications (19%). Overall, 61.9% of patients had a high risk of falling. Most falls (76.1%) occurred in patient rooms, and most of these occurred while wandering around. The most frequent reason for falls was slipping (14/21). For 16 of 21 patients, falls did not have immediate consequences, while 5 had contusions and 1 suffered a wound. Nobody needed to be admitted to the ER or suffered external hemorrhages or loss of consciousness. Conclusions: Non-slip socks represent an adequate alternative to well-fitting rubber-soled footwear. It seems that non-slip socks could prevent falls among hospitalized patients; nevertheless, further studies are necessary to clarify their role in preventing hospital falls and reducing injury rates.
Effects of Four Photo-Selective Colored Hail Nets on an Apple in Loess Plateau, China
Authors: Zhang Yutian , Chu Baohua , Zhang Dongdong , Li Qi , Li Qianjin , Li Xuewei , Liu Zeyuan , Ma Fengwang , Guan Qingmei , Zhang Dehui , Zou Yangjun
Published: September 2023

Hail, known as an agricultural meteorological disaster, can substantially constrain the growth of the apple industry. Presently, apple orchards use a variety of colored (photo-selective) hail nets as a preventative measure. However, it is unclear which color proves most effective for apple orchards. This study provides a systematic investigation of the impact of four photo-selective colored hail nets (white, blue, black, and green; with white being the control) on the microenvironment of apple orchards, fruit tree development, fruit quality, and yield over a two-year period (2020–2021). Different photo-selective nets do not evidently alter the intensity of light, although the nets’ shading effects decrease in the order from black to green to blue. Among them, blue nets increased the proportion of blue light, while green nets enhanced the proportion of green light. On the other hand, black, green, and blue nets diminished the proportion of red and far-red light. Such photo-selective nets effectively lowered soil temperature but did not have an impact on relative humidity and air temperature. Encasing apple trees with blue nets promoted growth, increasing shoot length, thickness, leaf area, and water content, while simultaneously decreasing leaf thickness. Black nets had comparable effects, although the impacts of green nets were inconsistent. Different photo-selective nets did not significantly influence the leaf shape index or overall chlorophyll content. However, black and green nets reduced the chlorophyll a/b ratio, while blue nets slightly boosted this ratio. Additionally, blue nets proved beneficial for apple trees’ photosynthesis. With the employment of a principal component analysis and comprehensive evaluation, this study concludes that blue nets offer the most favorable environmental conditions for apple growth while protecting apple orchards against hail, compared to black, white, and green nets.
Assessment of Electrical Brain Activity of Healthy Volunteers Exposed to 3.5 GHz of 5G Signals within Environmental Levels: A Controlled–Randomised Study
Authors: Jamal Layla , Yahia-Cherif Lydia , Hugueville Laurent , Mazet Paul , Lévêque Philippe , Selmaoui Brahim
Published: September 2023

Following the recent deployment of fifth-generation (5G) radio frequencies, several questions about their health impacts have been raised. Due to the lack of experimental research on this subject, the current study aimed to investigate the bio-physiological effects of a generated 3.5 GHz frequency. For this purpose, the wake electroencephalograms (EEG) of 34 healthy volunteers were explored during two “real” and “sham” exposure sessions. The electromagnetic fields were antenna-emitted in an electrically shielded room and had an electrical field root-mean-square intensity of 2 V/m, corresponding to the current outdoor exposure levels. The sessions were a maximum of one week apart, and both contained an exposure period of approximately 26 min and were followed by a post-exposure period of 17 min. The power spectral densities (PSDs) of the beta, alpha, theta, and delta bands were then computed and corrected based on an EEG baseline period. This was acquired for 17 min before the subsequent phases were recorded under two separate conditions: eyes open (EO) and eyes closed (EC). A statistical analysis showed an overall non-significant change in the studied brain waves, except for a few electrodes in the alpha, theta, and delta spectra. This change was translated into an increase or decrease in the PSDs, in response to the EO and EC conditions. In conclusion, this studhy showed that 3.5 GHz exposure, within the regulatory levels and exposure parameters used in this protocol, did not affect brain activity in healthy young adults. Moreover, to our knowledge, this was the first laboratory-controlled human EEG study on 5G effects. It attempted to address society’s current concern about the impact of 5G exposure on human health at environmental levels.
Enhancing Food Literacy and Food Security through School Gardening in Rural and Regional Communities
Authors: Holloway Timothy P. , Jayasinghe Sisitha , Dalton Lisa , Kilpatrick Michelle L. , Hughes Roger , Patterson Kira A. E. , Soward Robert , Burgess Kylie , Byrne Nuala M. , Hills Andrew P. , Ahuja Kiran D. K.
Published: September 2023

A qualitative case study approach with in-depth, semi-structured interviews of key school staff, and student feedback was used to assess a school kitchen and garden program in the regional area of North-West Tasmania, Australia. A detailed program description was produced to conduct a realist evaluation with a Context-Mechanism-Outcome configuration, followed by a program theory evaluation through the construction of a retrospective program logic model. Dedicated kitchen and garden spaces, knowledgeable teachers committed to the program, provision of sufficient materials and consumables, and support from the school and community were found to be the basic requirements to establish a program. Additionally, it is essential to integrate both the kitchen and garden teaching components into the school curriculum. The positive outcomes (e.g., engagement, participation, knowledge, skills, behavioral change) of the program were dependent on the underlying factors, including dedicated support of school leadership, teaching staff, and the parent body for effective student engagement in the teaching spaces and for wider engagement from families and the community. The students’ feedback provided supporting evidence of increased food literacy with improvements in their understanding, abilities, and attitudes towards gardening, producing healthy food, and preparing food. This may further lead to enhanced food security for students’ families and the broader community.
Dental Pain Medication Prescriptions in Minas Gerais, Brazil (2011–2021): A Time-Series Analysis
Authors: Cruz Alex Junio Silva , Martins Maria Auxiliadora Parreiras , Batista Victor Santos , de Aguilar Penido Henrique Pereira , Santos Jacqueline Silva , dos Santos Thiago Rezende , Sohn Woosung , de Castilho Lia Silva , Abreu Mauro Henrique Nogueira Guimarães
Published: September 2023

To describe trends of dentist-prescribed non-steroidal anti-inflammatory drugs (NSAIDs) and analgesics, from January 2011 to December 2021, as well as to examine the relationship between these trends and characteristics of public oral health services in Minas Gerais, Brazil. In this time-series analysis, all drugs were classified according to the Anatomical Therapeutic Chemical classification system. Drugs categorized as NSAIDs (M01A), and other analgesics and antipyretics (N02B) were included for analysis. The outcome was the number of Defined Daily Doses (DDDs)/1000 inhabitants/year for NSAIDs and analgesics in each town. Covariates referred to characteristics of public oral health services, such as coverage, estimates of dental procedures, and frequency of toothache. Linear time-series regression models were used to determine the influence of covariates on the outcome. Overall, there were 58,482 prescriptions of NSAIDs recorded in thirty-eight towns, while 47,499 prescriptions of analgesics in forty-three towns. For each year, there was a 0.38 (p < 0.001), and 0.28 (p < 0.001) increase in the average log of DDD/1000 inhabitants/year for NSAIDs and analgesics, respectively. A positive association was detected between toothache (p < 0.001) and the prescription of NSAIDs. Over the eleven years, there was a general rising trend in the prescriptions. Toothache was the only characteristic of public oral health services associated with the prescription rates of NSAIDs, implying that as the frequency of toothaches increase, so do the prescriptions of NSAIDs in the studied towns.
A Route for Investigating Psoriasis: From the Perspective of the Pathological Mechanisms and Therapeutic Strategies of Cancer
Authors: Wu Xingkang , Ma Yushuang , Wang Lu , Qin Xuemei
Published: September 2023

Psoriasis is an incurable skin disease that develops in about two-thirds of patients before the age of 40 and requires lifelong treatment; its pathological mechanisms have not been fully elucidated. The core pathological process of psoriasis is epidermal thickening caused by the excessive proliferation of epidermal keratinocytes, which is similar to the key feature of cancer; the malignant proliferation of cancer cells causes tumor enlargement, suggesting that there is a certain degree of commonality between psoriasis and cancer. This article reviews the pathological mechanisms that are common to psoriasis and cancer, including the interaction between cell proliferation and an abnormal immune microenvironment, metabolic reprogramming, and epigenetic reprogramming. In addition, there are common therapeutic agents and drug targets between psoriasis and cancer. Thus, psoriasis and cancer share a common pathological mechanisms–drug targets–therapeutic agents framework. On this basis, it is proposed that investigating psoriasis from a cancer perspective is beneficial to enriching the research strategies related to psoriasis.
Soft Tissue Manipulation Alters RANTES/CCL5 and IL-4 Cytokine Levels in a Rat Model of Chronic Low Back Pain
Authors: Marciano Carmela L. , Hiland Taylor A. , Jackson Krista L. , Street Sierra , Maris Carson , Ehrsam Andrew , Hum Julia M. , Loghmani Mary Terry , Chu Tien-Min G. , Kang Kyung S. , Lowery Jonathan W.
Published: September 2023

Low back pain (LBP) is a common musculoskeletal complaint that can impede physical function and mobility. Current management often involves pain medication, but there is a need for non-pharmacological and non-invasive interventions. Soft tissue manipulation (STM), such as massage, has been shown to be effective in human subjects, but the molecular mechanisms underlying these findings are not well understood. In this paper, we evaluated potential changes in the soft tissue levels of more than thirty pro- or anti-inflammatory cytokines following instrument-assisted STM (IASTM) in rats with chronic, induced LBP using Complete Freund’s Adjuvant. Our results indicate that IASTM is associated with reduced soft tissue levels of Regulated on Activation, Normal T cell Expressed and Secreted (RANTES)/Chemokine (C-C motif) ligand 5 (CCL5) and increased soft tissue levels of Interleukin (IL)-4, which are pro-inflammatory and anti-inflammatory factors, respectively, by 120 min post-treatment. IASTM was not associated with tissue-level changes in C-X-C Motif Chemokine Ligand (CXCL)-5/Lipopolysaccharide-Induced CXC Chemokine (LIX)–which is the murine homologue of IL-8, CXCL-7, Granulocyte-Macrophage-Colony Simulating Factor (GM-CSF), Intercellular Adhesion Molecule (ICAM)-1, IL1-Receptor Antagonist (IL-1ra), IL-6, Interferon-Inducible Protein (IP)-10/CXCL-10, L-selectin, Tumor Necrosis Factor (TNF)-α, or Vascular Endothelial Growth Factor (VEGF) at either 30 or 120 min post-treatment. Combined, our findings raise the possibility that IASTM may exert tissue-level effects associated with improved clinical outcomes and potentially beneficial changes in pro-/anti-inflammatory cytokines in circulation and at the tissue level.
Interaction of Substrates with γ-Secretase at the Level of Individual Transmembrane Helices—A Methodological Approach
Authors: Pauli Theresa M. , Julius Ayse , Costa Francesco , Eschrig Sabine , Moosmüller Judith , Fischer Lea , Schanzenbach Christoph , Schmidt Fabian C. , Ortner Martin , Langosch Dieter
Published: September 2023

Intramembrane proteases, such as γ secretase, typically recruit multiple substrates from an excess of single-span membrane proteins. It is currently unclear to which extent substrate recognition depends on specific interactions of their transmembrane domains (TMDs) with TMDs of a protease. Here, we investigated a large number of potential pairwise interactions between TMDs of γ secretase and a diverse set of its substrates using two different configurations of BLaTM, a genetic reporter system. Our results reveal significant interactions between TMD2 of presenilin, the enzymatic subunit of γ secretase, and the TMD of the amyloid precursor protein, as well as of several other substrates. Presenilin TMD2 is a prime candidate for substrate recruitment, as has been shown from previous studies. In addition, the amyloid precursor protein TMD enters interactions with presenilin TMD 4 as well as with the TMD of nicastrin. Interestingly, the Gly-rich interfaces between the amyloid precursor protein TMD and presenilin TMDs 2 and 4 are highly similar to its homodimerization interface. In terms of methodology, the economics of the newly developed library-based method could prove to be a useful feature in related future work for identifying heterotypic TMD−TMD interactions within other biological contexts.
Green Hydrogen Production through Ammonia Decomposition Using Non-Thermal Plasma
Authors: Moszczyńska Julia , Liu Xinying , Wiśniewski Marek
Published: September 2023

Liquid hydrogen carriers will soon play a significant role in transporting energy. The key factors that are considered when assessing the applicability of ammonia cracking in large-scale projects are as follows: high energy density, easy storage and distribution, the simplicity of the overall process, and a low or zero-carbon footprint. Thermal systems used for recovering H2 from ammonia require a reaction unit and catalyst that operates at a high temperature (550–800 °C) for the complete conversion of ammonia, which has a negative effect on the economics of the process. A non-thermal plasma (NTP) solution is the answer to this problem. Ammonia becomes a reliable hydrogen carrier and, in combination with NTP, offers the high conversion of the dehydrogenation process at a relatively low temperature so that zero-carbon pure hydrogen can be transported over long distances. This paper provides a critical overview of ammonia decomposition systems that focus on non-thermal methods, especially under plasma conditions. The review shows that the process has various positive aspects and is an innovative process that has only been reported to a limited extent.
Scopolamine-Induced Memory Impairment in Mice: Effects of PEA-OXA on Memory Retrieval and Hippocampal LTP
Authors: Belardo Carmela , Boccella Serena , Perrone Michela , Fusco Antimo , Morace Andrea Maria , Ricciardi Federica , Bonsale Roozbe , ELBini-Dhouib Ines , Guida Francesca , Luongo Livio , Bagetta Giacinto , Scuteri Damiana , Maione Sabatino
Published: September 2023

Transient global amnesia, both persistent and transient, is a very common neuropsychiatric syndrome. Among animal models for amnesia and testing new drugs, the scopolamine test is the most widely used for transient global amnesia (TGA). This study examined the scopolamine-induced deficits in working memory, discriminative memory, anxiety, and motor activity in the presence of intranasal PEA-OXA, a dual antagonist of presynaptic α2 and H3 receptors. Male C57BL/6 mice were treated with intraperitoneal scopolamine (1 mg/kg) with or without pre-treatment (15 min) or post-treatment (15 min) with intranasal PEA-OXA (10 mg/kg). It was seen that scopolamine induced deficits of discriminative and spatial memory and motor deficit. These changes were associated with a loss of synaptic plasticity in the hippocampal dentate gyrus: impaired LTP after lateral entorhinal cortex/perforant pathway tetanization. Furthermore, hippocampal Ach levels were increased while ChA-T expression was reduced following scopolamine administration. PEA-OXA either prevented or restored the scopolamine-induced cognitive deficits (discriminative and spatial memory). However, the same treatment did not affect the altered motor activity or anxiety-like behavior induced by scopolamine. Consistently, electrophysiological analysis showed LTP recovery in the DG of the hippocampus, while the Ach level and ChoA-T were normalized. This study confirms the neuroprotective and pro-cognitive activity of PEA-OXA (probably through an increase in the extracellular levels of biogenic amines) in improving transient memory disorders for which the available pharmacological tools are obsolete or inadequate and not directed on specific pathophysiological targets.
Hepatocellular Carcinoma Prevention in the Era of Hepatitis C Elimination
Authors: Lazarus Jeffrey V. , Picchio Camila A. , Colombo Massimo
Published: September 2023

The hepatitis C virus (HCV), a single-stranded RNA virus belonging to the Flaviviridae family, is a major cause of hepatocellular carcinoma (HCC) worldwide. Tumors caused by HCC have an increased mortality rate globally, which is more accentuated in Western countries. The carcinogenic potential of this virus is mediated through a wide range of mechanisms, spanning from the induction of chronic inflammation to oxidative stress and deregulation of cellular pathways by viral proteins. As the number of new infections continues unabated, HCC-related mortality should be prioritized through early detection, continued prevention of HCV transmission, and treatment of HCV with safe and efficacious direct antiviral agents (DAAs). People who inject drugs (PWID) are a significant reservoir of new HCV infections globally, and in order to eliminate hepatitis C as a global health threat, as set out by the World Health Organization, an integrated approach based on the optimization of care delivery and increased access to harm reduction and treatment for PWID is needed. Thanks to the development of safe and effective antiviral agents, eradication of the infection is now possible in almost all treated patients, leading to a significant reduction but not the elimination of the risk for HCC in cured patients. This is particularly relevant among aged populations who have cofactors of morbidity known to accelerate HCC progression, such as diabetes, obesity, and excessive alcohol consumption. Given the restless accumulation of individuals with cured HCV infection, the implementation of risk-stratified surveillance programs becomes impellent from a cost-effectiveness perspective, whereas the availability of a performant biomarker to predict HCC in cured patients remains an unmet clinical need.