bluuebunny/crossref_metadata_2025 huggingface dataset:
Who Benefits Most? Interactions between Personality Traits and Outcomes of Four Incremental Meditation and Yoga Treatments
Authors: Matko Karin , Berghöfer Anne , Jeitler Michael , Sedlmeier Peter , Bringmann Holger C.
Published: August 2022

Mind–Body Medicine (MBM) includes a broad range of interventions with proven preventive and clinical value, such as yoga and meditation. However, people differ in their preferences and response to different MBM treatments and it remains unclear who benefits most from what type of practice. Thus, finding moderators of treatment outcome seems to be a promising approach. This was the aim of the present study. We conducted a single-case multiple-baseline study investigating the outcomes and moderators of four different MBM treatments. Fifty-seven healthy participants with no prior experience were randomly assigned to three baselines (7, 14, and 21 days) and four eight-week treatments: mantra meditation alone, meditation plus physical yoga, meditation plus ethical education and meditation plus yoga and ethical education. We analysed the data using effect size estimation, multiple regression and cluster analyses. High anxiety, high absorption, low spirituality, low openness and younger age were associated with a range of positive outcomes, such as increased wellbeing or decentering and decreased mind wandering. Receiving ethical education consistently improved wellbeing, while engaging in physical yoga reduced mind wandering. In the cluster analysis, we found that participants with a more maladaptive personality structure enhanced their emotion regulation skills more. Consequently, people do differ in their response to MBM interventions and more vulnerable people, or those high in absorption, seem to benefit more. These findings could support the development of custom-tailored MBM interventions and help clinicians to make scientifically sound recommendations for their patients.
Results of a Five-Year Experience in First Trimester Preeclampsia Screening
Authors: Capriglione Stella , Gulino Ferdinando Antonio , Latella Silvia , De Felice Giovanna , Filippini Maurizio , Farinelli Miriam , Martire Francesco Giuseppe , Viora Elsa
Published: August 2022

Background and Objectives: The study aimed to evaluate the ability defining the risk of developing preeclampsia by a screening test carried out in the first trimester (between 11 + 0 and 13 + 6 weeks of gestational age), in order to identify high-risk women requiring more intensive health surveillance. The secondary objective was to evaluate the ability of this test to predict the risk of adverse obstetric outcomes such as fetal growth restriction, intrauterine fetal death, gestational hypertension, HELLP syndrome, placental abruption, and preterm birth. Materials and Methods: This was a single-center study, conducted at the Operative Unit of Obstetrics of the State Hospital of the Republic of San Marino. Medical history was collected at the time of enrolment in writing. Subsequently, obstetric outcomes were collected for each enrolled woman, through the analysis of medical records. Results: From October 2014 to May 2019, 589 pregnant women were recruited, of whom, 474 (80.5%) were included in the “low-risk” group, and 115 (19.5%) in the “high-risk” group. At the time of analysis of this population, the obstetric outcomes were available for 498 women (84.5%), while 91 cases (15.5%) were current pregnancies. The PI of the uterine arteries was not significantly different between the two study groups. Otherwise, a significant difference was highlighted for MAP, which is higher in the case of pregnancies at high risk based on the risk factors only, and for PAPP-A, higher in the case of low-risk pregnancies. Regarding the percentage of fetal DNA, according to the most recent literature data, in our series, we report a statistically significant difference of the average between the low and high-risk groups. Conclusions: In our study, we demonstrate that the multiparametric screening test for early PE performed well in identifying women at high risk of early PE, which certainly has the most severe maternal–fetal outcomes. The data reported that ASA intake at low doses is significantly higher in the population with high-risk tests for both early PE and late PE suggest once again that anamnestic evaluation plays an essential role in women’s screening.
Surgical Management of Chiari Malformation Type I Associated with Syringomyelia: Outcome of Surgeries Based on the New Classification and Study of Cerebrospinal Fluid Dynamics
Authors: Nishikawa Misao , Yamagata Toru , Naito Kentarou , Kunihiro Noritsugu , Sakamoto Hiroaki , Hara Mistuhiro , Ohata Kenji , Goto Takeo
Published: August 2022

Introduction: The mainstay of treatment of syringomyelia associated with Chiari malformation type I (CM-I) is the management of CM-I to normalize the cerebrospinal fluid (CSF) flow at the foramen magnum. CM-I is classified into three independent types. Surgical treatment was selected based on the mechanism of hindbrain ptosis in each CM-I type. Materials and Methods: Foramen magnum decompression (FMD: 213 cases), expansive suboccipital cranioplasty (ESCP: 87 cases), and craniocervical fixation (CCF: 30 cases) were performed. CSF flow dynamics were assessed pre- and post-surgery using cine phase contrast magnetic resonance imaging. During surgery, CSF flow dynamics were examined using color Doppler ultrasonography (CDU). Results: ESCP and FMD demonstrated high rates of improvement in neurological symptoms and signs (82.7%), whereas CCF demonstrated a high rate of improvement in neurological symptoms (89%). The pre-operative maximum flow velocity (cm/s) was significantly lower in patients than in controls and increased post-operatively. During surgery, CDU indicated that the volume of the major cistern was 8 mL, and the maximum flow velocity was >3 mL/s. Conclusions: An appropriate surgical treatment should be selected for CM-I to correct hindbrain ptosis. In addition, it is necessary to confirm the normalization of CSF flow at the foramen of Magendie.
Low Doses of Celecoxib Might Promote Phenotype Switching in Cutaneous Melanoma Treated with Dabrafenib—Preliminary Study
Authors: Tudor Diana Valentina , Florea Adrian , Cenariu Mihai , Olteanu Diana Elena , Farcaș Marius , Hopârtean Andreea , Clichici Simona Valeria , Filip Gabriela Adriana
Published: August 2022

Background: Cutaneous melanoma is a heterogeneous tumor with a rapidly switching molecular and cellular phenotype. The invasive phenotype switching characterized by MITFlow/AXLhigh predicts early resistance to multiple targeted drugs in melanoma. Celecoxib proved to be a valuable adjuvant in cutaneous melanoma in preclinical studies. Our in vitro study evaluated for the first time whether celecoxib could prevent phenotype switching in two human melanoma cell lines treated with dabrafenib. Methods: All in vitro experiments were carried out on BRAF-V600E-positive A375 and SK-MEL-28 human melanoma cell lines, and subjected to a celecoxib and dabrafenib drug combination for 72 h. Melanoma cells were already in the MITFlow/AXLhigh end of the spectrum. Of main interest was the evaluation of the key proteins expressed in phenotype switching (TGF-β, MITF, AXL, YAP, TAZ), as well as cell death mechanisms correlated with oxidative stress production. Results: Celecoxib significantly enhanced the apoptotic effect of dabrafenib in each melanoma cell line compared to the dabrafenib group (p < 0.0001). Even though celecoxib promoted low MITF expression, this was correlated with high receptor tyrosine kinase AXL levels in A375 and SK-MEL-28 cell lines (p < 0.0001), a positive marker for the phenotype switch to an invasive state. Conclusion: This preliminary study highlighted that celecoxib might promote MITFlow/AXLhigh expression in cutaneous melanoma treated with dabrafenib, facilitating phenotype switching in vitro. Our results need further confirmation, as this finding could represent an important limitation of celecoxib as an antineoplastic drug.
Intrapatient Comparison of Coblation versus Electrocautery Tonsillectomy in Children: A Randomized, Controlled Trial
Authors: Choi Kyu Young , Ahn Jae-Cheul , Rhee Chae-Seo , Han Doo Hee
Published: August 2022

Many surgical instruments have been introduced and compared for safety and surgical efficiency in tonsillectomy. This study aimed to compare postoperative pain between coblation and conventional monopolar electrocautery tonsillectomy by intrapatient comparison in children. Thirty pediatric patients over six years of age undergoing tonsillectomies were enrolled. Coblation and electrocautery were used to remove both tonsils in one patient; one was removed by coblation and the other by electrocautery. The coblation side was randomly selected, and it was blinded to the patients. Each side’s daily pain scores were collected on the visual analogue scale (VAS) during ten postoperative days. On the day of surgery, 22 (73%) patients identified less pain on the coblation side, while others felt similar pain. The mean pain scores were significantly lower on the coblation side during the postoperative ten days (except for the 6th and 8th) than on the electrocautery side. The duration of severe pain (VAS > 5) was significantly shorter on the coblation side than on the electrocautery side (2.0 versus 3.7 days, respectively; p = 0.042). Coblation tonsillectomy induced less pain than electrocautery in pediatric patients; therefore, surgeons could choose the coblator as a surgical instrument for tonsillectomy to improve the pediatric postoperative quality of life.
Special Issue “Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: Diagnosis and Treatment”
Authors: Lorusso Lorenzo , Ricevuti Giovanni
Published: August 2022

Chronic fatigue syndrome, or myalgic encephalomyelitis (CFS/ME), is a debilitating disease with unknown causes that is more common in women and tends to develop between patients’ mid-20s and mid-40s [...]
Current Challenges in the Management of Sepsis and Septic Shock: Personalized, Physiology-Guided Treatment
Authors: Chalkias Athanasios
Published: August 2022

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection affecting millions of people each year [...]
Current Status of Internet Gaming Disorder (IGD) in Japan: New Lifestyle-Related Disease in Children and Adolescents
Authors: Imataka George , Sakuta Ryoichi , Maehashi Akira , Yoshihara Shigemi
Published: August 2022

The World Health Organization recognizes internet gaming disorder (IGD) as a disorder that causes problems in daily life as a result of excessive interest in online games. The causes of IGD have become more apparent in recent years. Because of prolonged exposure to games, the mechanisms controlling the reward system, such as the prefrontal cortex, limbic system, and amygdala of the cerebrum, do not function properly in IGD. This mechanism is similar to that of various behavioral addictions, such as gambling addiction. IGD is particularly risky in children and adolescents because it easily causes brain dysfunction, especially in the developing brain. IGD should be regarded as a new lifestyle-related disease in younger individuals, and lifestyle modifications, including counseling and family therapy, are critical for its management.
Gelatin/Cellulose Nanofiber-Based Functional Nanocomposite Film Incorporated with Zinc Oxide Nanoparticles
Authors: Roy Swarup , Biswas Deblina , Rhim Jong-Whan
Published: August 2022

A novel bio-based nanocomposite film was developed using the combination of gelatine and cellulose nanofiber (CNF) as a polymer matrix and zinc oxide nanoparticles (ZnONP) as nanofillers. The nanocomposite film solution was developed using simple solution mixing and film prepared by the following casting methods. The fabricated nanocomposite film containing 2 wt% of ZnONP shows excellent UV-light barrier properties (>95%) and high transparency (>75%). The presence of ZnONP also improves the mechanical strength of the film by ~30% compared to pristine gelatin/CNF-based film, while the flexibility and rigidity of the nanocomposite film were also slightly improved. The addition of ZnONP slightly increased (~10%) the hydrophobicity while the water vapor barrier properties remain unaltered. The hydrodynamic properties of the bio-based film were also changed in the presence of ZnONP, moisture content and the swelling ratio slightly enhanced, whereas water solubility was decreased. Moreover, the integration of ZnONP introduced antibacterial activity toward foodborne pathogens. The fabricated bio-based nanocomposite film could be useful in active packaging applications.
Impact of Dialysis Clinical Operating Conditions on Human Serum Protein-Mediated Inflammatory Biomarkers Released in Patients Using Polyarylethersulfone Membranes
Authors: Westphalen Heloisa , Saadati Shaghayegh , Bahig Jumanah , Doan Huu , Shoker Ahmed , Abdelrasoul Amira
Published: August 2022

Hemodialysis (HD) is a life-sustaining treatment of crucial importance in managing end-stage renal disease (ESRD). However, this membrane-based therapy is associated with acute side-effects due to bioincompatibility issues and limitations on the removal of uremic toxins. The present study assessed the influence of hydrodynamic conditions applied during HD treatment on protein-mediated inflammatory and thrombotic responses. The membrane modules considered are commonly used in Canadian hospitals and are comprised of a polymer blend of polyarylether sulfone-polyvinylpyrrolidone (PAES). The membranes morphology and hydrophilicity were assessed using SEM, AFM, BET, and zeta potential. An in vitro study evaluated the adsorptive behavior of fibrinogen (FB) to the membrane under different flow conditions. Lower rates of 200 mL/min promoted slower and significant FB adsorption, leading to more severe inflammatory and thrombotic responses. Hydrodynamic conditions also affected the concentration of all inflammatory biomarkers. Lower flow rates triggered more complement activation as well as coagulation, clotting, and inflammatory responses compared to higher flow rates. At the end of the dialysis session, patients treated with a Qb of 200 mL/min presented a significant increase in the concentration of C5a (232%), properdin (114%), serpin (545%), IL-1α (50%), IL-6 (450%), and vWF (212%). IL-1β and TNF-α concentrations declined by 12.5 and 35.5%, respectively. Male patients experienced more severe inflammatory responses than female patients at the operating conditions considered. Comparing the pre- and post-dialysis levels of female and male patients, female patients experienced significantly higher levels of IL-6 and properdin, while male patients presented higher levels of C5a, IL-1α, and IL-6. The results of this study will help clinical doctors evaluate the impact of HD operating conditions on blood activations before prescribing treatment and inform expectations for outcomes in female and male patients.
Dentin Sealing of Calcium Silicate-Based Sealers in Root Canal Retreatment: A Confocal Laser Microscopy Study
Authors: Ortiz-Blanco Blanca , Sanz José Luis , Llena Carmen , Lozano Adrián , Forner Leopoldo
Published: August 2022

The aim of the present in vitro study was to evaluate the intratubular penetration of three bioceramic sealers in root canal retreatment. Here, 30 single-rooted human teeth were instrumented with the Protaper Universal system and filled with gutta-percha and the epoxy-resin-based sealer AH Plus mixed with rhodamine B. After two weeks in a humid environment, they were re-instrumented with Reciproc Blue and divided into three groups according to the endodontic sealer to be used in the re-filling (n = 10): G1: CeraSeal, G2: TotalFill BC Sealer, G3: TotalFill BC Sealer HiFlow. For the filling, a single cone technique was used, and the respective sealers were mixed with fluorescein. The roots were then sectioned at 2, 5, and 8 mm (apical, medial, and coronal measurement points, respectively) from the apex, and the dentinal tubule penetration depth and percentage of penetration around the canal perimeter were evaluated by means of confocal laser scanning microscopy (CLSM). Penetration between groups was compared using the Kruskal−Wallis test, and within each group using the Wilcoxon test. Statistical significance was established at p < 0.05. A non-significant reduction was found in the penetration depths and in a percentage of penetration around the canal perimeter between AH Plus and the tested calcium-silicate-based sealers (p > 0.05). Consequently, this reduction may not affect the three-dimensional seal of the root canal system in a negative manner. The penetration depth and percentage of penetration around the canal perimeter at both the root canal treatment and retreatment were significantly reduced from the coronal to apical points in all groups (p < 0.05).
Trilateral Multi-Functional Polyamide 12 Nanocomposites with Binary Inclusions for Medical Grade Material Extrusion 3D Printing: The Effect of Titanium Nitride in Mechanical Reinforcement and Copper/Cuprous Oxide as Antibacterial Agents
Authors: Vidakis Nectarios , Petousis Markos , Mountakis Nikolaos , Korlos Apostolos , Papadakis Vassilis , Moutsopoulou Amalia
Published: August 2022

In this work, for the first time, polyamide 12 (PA12) nanocomposites with binary inclusions in material extrusion (MEX) 3D printing were developed. The aim was to achieve an enhanced mechanical response with the addition of titanium nitride (TiN) and antibacterial performance with the addition of copper (Cu) or cuprous oxide (Cu2O), towards the development of multi-functional nanocomposite materials, exploiting the 3D printing process benefits. The prepared nanocomposites were fully characterized for their mechanical properties. The thermal properties were also investigated. Morphological characterization was performed with atomic force microscopy (AFM) and scanning electron microscopy (SEM). The antibacterial performance was investigated with an agar-well diffusion screening process. Overall, the introduction of these nanofillers induced antibacterial performance in the PA12 matrix materials, while at the same time, the mechanical performance was significantly increased. The results of the study show high potential for expanding the areas in which 3D printing can be used.
Metacognitive and Non-Metacognitive Processes in Arithmetic Performance: Can There Be More than One Meta-Level?
Authors: Csíkos Csaba
Published: August 2022

The nature of the development of arithmetic performance has long been intensively studied, and available scientific evidence can be evaluated and synthesized in light of Nelson and Narens’ model of metacognition. According to the Nelson–Narens model, human cognition can be split into two or more interrelated levels. Obviously, in the case of more than two levels, cognitive processes from at least one level can be described as both meta- and object-level processes. The question arises whether it is possible that the very same cognitive processes are both controlled and controlling. The feasibility of owning the same cognitive processes—which are considered the same from an external point of view of assessment—as both meta- and object-level processes within the same individual opens the possibility of investigating the transition from meta-level to object-level. Modeling cognitive development by means of a series of such transitions calls forth an understanding of possible developmental phases in a given domain of learning. The developmental phases of arithmetic performance are described as a series of transitions from arithmetical facts to strategies of arithmetic word problem solving. For school learning and instruction, the role of metacognitive scaffolding as a powerful educational approach is emphasized.
Responses of Freshwater Calcifiers to Carbon-Dioxide-Induced Acidification
Authors: Ninokawa Aaron T. , Ries Justin
Published: August 2022

Increased anthropogenic carbon dioxide (CO2) in the atmosphere can enter surface waters and depress pH. In marine systems, this phenomenon, termed ocean acidification (OA), can modify a variety of physiological, ecological, and chemical processes. Shell-forming organisms are particularly sensitive to this chemical shift, though responses vary amongst taxa. Although analogous chemical changes occur in freshwater systems via absorption of CO2 into lakes, rivers, and streams, effects on freshwater calcifiers have received far less attention, despite the ecological importance of these organisms to freshwater systems. We exposed four common and widespread species of freshwater calcifiers to a range of pCO2 conditions to determine how CO2-induced reductions in freshwater pH impact calcium carbonate shell formation. We incubated the signal crayfish, Pacifastacus leniusculus, the Asian clam, Corbicula fluminea, the montane pea clam, Pisidium sp., and the eastern pearlshell mussel, Margaritifera margaritifera, under low pCO2 conditions (pCO2 = 616 ± 151 µatm; pH = 7.91 ± 0.11), under moderately elevated pCO2 conditions (pCO2 = 1026 ± 239 uatm; pH = 7.67 ± 0.10), and under extremely elevated pCO2 conditions (pCO2 = 2380 ± 693 uatm; pH = 7.32 ± 0.12). Three of these species exhibited a negative linear response to increasing pCO2 (decreasing pH), while the fourth, the pea clam, exhibited a parabolic response. Additional experiments revealed that feeding rates of the crayfish decreased under the highest pCO2 treatment, potentially contributing to or driving the negative calcification response of the crayfish to elevated pCO2 by depriving them of energy needed for biocalcification. These results highlight the potential for freshwater taxa to be deleteriously impacted by increased atmospheric pCO2, the variable nature of these responses, and the need for further study of this process in freshwater systems.
Short Sea Shipping, Multimodality, and Sustainable Maritime Transportation
Authors: Santos Tiago A.
Published: August 2022

Short sea shipping is an important research topic and is of practical interest for the shipping and transport industries in many regions across the globe [...]
Contribution of Synthetic Data Generation towards an Improved Patient Stratification in Palliative Care
Authors: Hahn Waldemar , Schütte Katharina , Schultz Kristian , Wolkenhauer Olaf , Sedlmayr Martin , Schuler Ulrich , Eichler Martin , Bej Saptarshi , Wolfien Markus
Published: August 2022

AI model development for synthetic data generation to improve Machine Learning (ML) methodologies is an integral part of research in Computer Science and is currently being transferred to related medical fields, such as Systems Medicine and Medical Informatics. In general, the idea of personalized decision-making support based on patient data has driven the motivation of researchers in the medical domain for more than a decade, but the overall sparsity and scarcity of data are still major limitations. This is in contrast to currently applied technology that allows us to generate and analyze patient data in diverse forms, such as tabular data on health records, medical images, genomics data, or even audio and video. One solution arising to overcome these data limitations in relation to medical records is the synthetic generation of tabular data based on real world data. Consequently, ML-assisted decision-support can be interpreted more conveniently, using more relevant patient data at hand. At a methodological level, several state-of-the-art ML algorithms generate and derive decisions from such data. However, there remain key issues that hinder a broad practical implementation in real-life clinical settings. In this review, we will give for the first time insights towards current perspectives and potential impacts of using synthetic data generation in palliative care screening because it is a challenging prime example of highly individualized, sparsely available patient information. Taken together, the reader will obtain initial starting points and suitable solutions relevant for generating and using synthetic data for ML-based screenings in palliative care and beyond.
Effectiveness of a Comprehensive Mental Health Literacy Educational Programme for Junior High School Students: A Randomised Controlled Trial Examining Changes in Their Knowledge, Attitudes, and Behaviour
Authors: Mori Ryoichi , Uchino Takashi , Mizuno Masafumi , Yamaguchi Taiju , Katagiri Naoyuki , Nemoto Takahiro
Published: August 2022

Background: This study evaluated the effectiveness of a comprehensive mental health literacy (MHL) educational programme known as “Sanita” for improving junior high school students’ knowledge of mental illness, attitudes towards people with mental health problems, and help-seeking behaviour. Methods: A randomised controlled trial with a parallel-group design was conducted. A total of 125 students (51 in the intervention group and 74 in the control group) received three 50-min classes and completed self-report questionnaires (Mental Illness and Disorder Understanding Scale, MIDUS; Reported and Intended Behaviour Scale, RIBS-J; and an original questionnaire investigating help-seeking behaviour) before and after the programme and three months later. Results: Regarding MIDUS, the post-test and 3-month follow-up test results showed a significant main effect of time-by-group interactions in a linear mixed model. Regarding RIBS-J, the post-test results showed a significant main effect of time-by-group interactions; however, the 3-month follow-up test showed no significant effect. No significant effects of time-by-group interactions were seen in the post-test and 3-month follow-up test results for help-seeking behaviour in a logistic regression-mixed model. Conclusions: The Sanita MHL educational programme was longitudinally effective at improving junior high school students’ knowledge of mental illness, although improvements in attitudes and help-seeking behaviour were insufficient.
Probiotics and Gut Microbiota in Obesity: Myths and Realities of a New Health Revolution
Authors: León Aguilera Xavier Eugenio , Manzano Alexander , Pirela Daniela , Bermúdez Valmore
Published: August 2022

Obesity and its comorbidities are humans’ most prevalent cardio-metabolic diseases worldwide. Recent evidence has shown that chronic low-grade inflammation is a common feature in all highly prevalent chronic degenerative diseases. In this sense, the gut microbiota is a complete ecosystem involved in different processes like vitamin synthesis, metabolism regulation, and both appetite and immune system control. Thus, dysbiosis has been recognised as one of the many factors associated with obesity due to a predominance of Firmicutes, a decrease in Bifidobacterium in the gut, and a consequent short-chain fatty acids (SCFA) synthesis reduction leading to a reduction in incretins action and intestinal permeability increase. In this context, bacteria, bacterial endotoxins, and toxic bacterial by-products are translocated to the bloodstream, leading to systemic inflammation. This review focuses on gut microbiota composition and its role in obesity, as well as probiotics and prebiotics benefits in obesity.
R&D, Industrial Policy and Growth
Authors: Dang Alicia H. , Samaniego Roberto
Published: August 2022

An issue with estimating the impact of industrial support is that the firms that receive support may be politically connected, introducing omitted variable bias. Applying fixed-effects regressions on Vietnamese panel data containing several proxies for political connectedness to correct this bias, we find that firms that receive industrial support in the form of tax holidays experience more rapid productivity growth, particularly in R&D-intensive industries, and less so among politically connected firms. These findings do not appear to be due to the presence of financing constraints. We then develop a second-generation Schumpeterian growth model with many industries, and show that tax holidays disproportionately raise productivity growth in R&D-intensive industries. These results are significant and important for governments, especially those in transition and developing countries, in better targeting their industrial policy to facilitate higher productivity growth.
Predictors Associated with Type 2 Diabetes Mellitus Complications over Time: A Literature Review
Authors: Elhefnawy Marwa Elsaeed , Ghadzi Siti Maisharah Sheikh , Noor Harun Sabariah
Published: August 2022

Early detection of type 2 diabetes mellitus (T2DM) complications is essential to prevent disability and death. Risk prediction models are tools to estimate the probability that an individual with specific risk factors will develop a future condition within a certain time period. A predictive model that incorporates time to quantify the risk of T2DM complications such as cardiovascular diseases (CVD) event is still lacking. Well-established and validated predictive models of T2DM complications are vital to stratify patients based on their risks; thus, individualization therapy could be optimized. New approaches (e.g., the parametric approach) are needed in developing predictive models of T2DM complications by incorporating new and time-varying predictors that may improve the existing models’ predictive ability. This review aimed (1) to summarize the reported predictors for the five main complications of T2DM, which include cardiovascular diseases, ischemic stroke, diabetic nephropathy, diabetic neuropathy, and diabetic retinopathy, and (2) to highlight the persistent need for future risk score models as screening tools for the early prevention of T2DM complications.
A Study of Carbon Stock Changes in the Alpine Grassland Ecosystem of Zoigê, China, 2000–2020
Authors: Qu Rui , He Li , He Zhengwei , Wang Bing , Lyu Pengyi , Wang Jiaxian , Kang Guichuan , Bai Wenqian
Published: August 2022

Terrestrial carbon sequestration capacity is an important indicator of ecosystem service function, and the carbon storage value can reflect the climate regulation capacity of the regional ecological environment. The Zoigê alpine grassland is a representative area of the Qinghai-Tibet Plateau grassland ecosystem, with carbon sequestration types such as alpine grassland and marsh meadow and also an important water-conserving area in the upper reaches of the Yangtze River and the Yellow River. In this study, based on the land use/cover change pattern of the Zoigê alpine grassland region from 2000 to 2020, the carbon density coefficients corrected by the regional average annual precipitation and temperature factors were used to assess the carbon stocks of the Zoigê alpine grassland for three periods from 2000 to 2020 using the InVEST model. The results showed that the carbon stocks of the Zoigê alpine grassland region were 786.19 Tg, 780.02 Tg, and 775.22 Tg in 2000, 2010, and 2020, respectively, with a cumulative loss of 10.97 Tg and carbon densities of 183.70 t/ha, 182.26 t/ha, and 181.14 t/ha, showing a decreasing trend year by year. The carbon stock of the grassland ecosystem is the absolute contributor to the regional carbon stock, and the carbon stock accounts for 75.28% of the total carbon stock. The increase in the cultivated land area with a lower carbon density and the decrease in the grassland area with a higher carbon density are the main factors leading to the decrease in the carbon stock in the regional ecosystem of the Zoigê alpine grassland.
Coupling Coordination Analysis of the Ecology and Economy in the Yellow River Basin under the Background of High-Quality Development
Authors: An Shi , Zhang Shaoliang , Hou Huping , Zhang Yiyan , Xu Haonan , Liang Jie
Published: August 2022

The concept of high-quality development has become the current theme of China’s economic construction. High-quality development requires maintaining a healthy and cyclical approach to economic development, which is a challenge in the original development approach. Yet, a great deal of evidence suggests that there is a strong interrelationship between economic development and the ecological environment, and developing a method to quantify this interrelationship is important for studying the extent of high-quality development. Here, we propose a new indicator system using the coupling degree model and the coupling coordination degree model to assess the coupled coordination of economic development and the ecological environment in the Yellow River basin as a whole and in each province. We found that: (1) the economic development and ecological health of the Yellow River basin exhibit a slowly increasing trend; (2) the coupling degree of the economic development and ecological environment is high, indicating that the interaction between the economy and ecology is very strong; and (3) the increasing degree of coupling and coordination reflects the trend of continuous improvement and coordination in the relationship between the economy and ecological environment, and the level of high-quality development in the basin has continuously increased. The results of this study indicate that to continue to strengthen the high-quality development in the Yellow River basin, the contradiction between the economy and ecology should be alleviated, and coordinated development of both should be achieved.
Theoretical Development Model for Rural Settlements against Rural Shrinkage: An Empirical Study on Pingyin County, China
Authors: Yu Shangkun , Miao Yi , Li Mengcheng , Ding Xiaoming , Wang Chengxin , Dou Wangsheng
Published: August 2022

China’s rural areas face population loss and expanded residential land in the context of rapid urbanization. The increasing hollowing of villages leads to extensive land use, making it necessary to optimize and consolidate rural settlements immediately. Therefore, how to choose an appropriate development model for rural settlements is at issue. This article builds a theoretical development model for rural settlements based on their primary development conditions and spatial patterns. It determines the development model according to the classification matrix formed by interweaving different elements in each dimension. Finally, it demonstrates the model through a case study on Pingyin County, China. The empirical findings for Pingyin County are as follows. (1) The scale of rural settlements increased from 2010 to 2020, and the agglomeration and spatial correlation intensified, but they tended to be irregular. (2) The various elements of the development foundation showed apparent spatial differentiation, and the spatial distribution of rural settlements at different levels presented a core–edge structure. (3) The development of rural settlements was reduced to six models: in-situ urbanization, satellite urbanization, competitive-industry-driven, characteristic-tourism-driven, modern-agriculture-driven, and village relocation. Finally, the article proposes different development paths for different development models.
Past and Future Land Use/Land Cover Changes in the Ethiopian Fincha Sub-Basin
Authors: Regasa Motuma Shiferaw , Nones Michael
Published: August 2022

The increasing human pressure on African regions is recognizable when looking at Land Use Land Cover (LULC) change maps, generally derived from satellite imagery. Using the Ethiopian Fincha watershed as a case study, the present work focuses on (i) identifying historical LULC change in the period 1989–2019; (ii) estimating LULC in the next thirty years, combining Geographical Information Systems (GIS) with Land Change Modelling (LCM). Landsat 5/8 images were combined with field evidence to map LULC in three reference years (1989, 2004, 2019), while the Multi-Layer Markov Chain (MPL-MC) model of LCM was applied to forecast LULC in 2030, 2040, and 2050. The watershed was classified into six classes: waterbody, grass/swamp, built-up, agriculture; forest; and shrub. The results have shown that, in the past 30 years, the Fincha watershed experienced a reduction in forest and shrubs of about −40% and −13%, respectively, mainly due to ever-increasing agricultural activities, and such a trend is also expected in the future. In fact, for the period 2019–2050, LCM simulated a significant decrease in both forest and shrubs (around −70% and −20%, respectively), in favor of more areas covered by grass (19%) and built-up (20%). It is worth noting that a decrease in natural forests can drive an increase in soil erosion, fostering siltation in the water reservoirs located in the sub-basin. The study pointed out the urgency of taking actions in the sub-basin to counteract such changes, which can eventually lead to a less sustainable environment.
Livelihood Vulnerability Index: Gender Dimension to Climate Change and Variability in REDD + Piloted Sites, Cross River State, Nigeria
Authors: Basiru Adeniyi Okanlawon , Oladoye Abiodun Olusegun , Adekoya Olubusayo Omotola , Akomolede Lucas Aderemi , Oeba Vincent Onguso , Awodutire Opeyemi Oluwaseun , Charity Fredrick , Abodunrin Emmanuel Kolawole
Published: August 2022

Vulnerability to climate change and variability impacts has been identified as a major cog in the wheel of both livelihood and resilience, particularly in vulnerable groups in rural areas. This study aims to assess genders’ vulnerability dimension to climate change and variability in REDD + (Reducing Emission from Deforestation and Forest Degradation+) piloted site/clusters, Cross River State, Nigeria. Data were proportionately collected from selected 200 respondents on gender disaggregated level using questionnaires. The assessment adopted the sustainable livelihood approach (livelihood vulnerability index) and compared the results with the IPCC vulnerability standard of exposure, sensitivity and adaptive capacity weighted mean. The results revealed a significant difference in the vulnerability dimension of both women and men disaggregated levels (LVI: men 0.509, women 0.618). The women category was more vulnerable to six out of seven major components of LVI assessed: (livelihood strategies (0.646), social networks (0.364), water (0.559), health (0.379), food and nutrition (0.507), and natural hazards and climate variability (0.482), while men only vulnerable to socio-demographic major component (0.346). Vulnerability indices also showed women to be more exposed (0.482), and sensitive (0.489) with the least adaptive capacities (0.462) to the climate change and variability impacts. Overall, on the IPCC-LVI index, women are more vulnerable (0.0098) to climate change and variability impacts than men (−0.0093). The study recommends that the women’s category resilience and adaptive capacity should be empowered in adaptation projects in climate change such as REDD + (Reducing Emissions from Deforestation and Forest Degradation+) to reduce their vulnerability to impacts of climate change and variability in the context of exposure, sensitivity, and adaptive capacities. This will be instrumental in formulating policies to address the specific needs of gender categories in reducing vulnerability to climate change and variability. This pragmatic approach may be used to monitor gender vulnerability dimension, and livelihood enhancement and evaluate potential climate change adaptation programs. Additionally, the introduction of IPCC-LVI as a baseline instrument will enhance information on gender resilience and adaptive capacity for policy effectiveness in a data-scarce region particularly Africa.
How Governance Tools Facilitate Citizen Co-Production Behavior in Urban Community Micro-Regeneration: Evidence from Shanghai
Authors: Wu Jinpeng , Xiong Jing
Published: August 2022

Citizen participation and input in urban community micro-regeneration is a co-production behavior that is conducive to improving citizens’ sense of belonging, thereby promoting community governance. In the context of low co-production levels amongst citizens, how the government adopts mobilization instruments is an important challenge. This paper investigates whether governance tools can facilitate citizen co-production behavior in an urban community micro-regeneration setting using a structural equation modeling method and the stimulus organism response theory. Based on a survey of citizens who participated in community micro-regeneration co-production in Shanghai, this paper demonstrates the significant positive effects associated with information- and incentive-based tools in citizen in-role and extra-role co-production behavior; however, the effect degree was shown to differ. Moreover, the level of perceived benefits is a significant mediating variable between governance tools and in-role co-production behavior. In this study, we constructed and verified a novel and valuable theoretical perspective with which to explore urban regeneration. It was concluded that policymakers should follow the governance principle of classified development and tool matching for citizen co-production behavior in urban community micro-regeneration.
New Insights into Non-Alcoholic Fatty Liver Disease and Coronary Artery Disease: The Liver-Heart Axis
Authors: Cazac Georgiana-Diana , Lăcătușu Cristina-Mihaela , Mihai Cătălina , Grigorescu Elena-Daniela , Onofriescu Alina , Mihai Bogdan-Mircea
Published: August 2022

Non-alcoholic fatty liver disease (NAFLD) represents the hepatic expression of the metabolic syndrome and is the most prevalent liver disease. NAFLD is associated with liver-related and extrahepatic morbi-mortality. Among extrahepatic complications, cardiovascular disease (CVD) is the primary cause of mortality in patients with NAFLD. The most frequent clinical expression of CVD is the coronary artery disease (CAD). Epidemiological data support a link between CAD and NAFLD, underlain by pathogenic factors, such as the exacerbation of insulin resistance, genetic phenotype, oxidative stress, atherogenic dyslipidemia, pro-inflammatory mediators, and gut microbiota. A thorough assessment of cardiovascular risk and identification of all forms of CVD, especially CAD, are needed in all patients with NAFLD regardless of their metabolic status. Therefore, this narrative review aims to examine the available data on CAD seen in patients with NAFLD, to outline the main directions undertaken by the CVD risk assessment and the multiple putative underlying mechanisms implicated in the relationship between CAD and NAFLD, and to raise awareness about this underestimated association between two major, frequent and severe diseases.
The Role of the Left Atrium: From Multimodality Imaging to Clinical Practice: A Review
Authors: Beltrami Matteo , Dei Lorenzo-Lupo , Milli Massimo
Published: August 2022

In recent years, new interest is growing in the left atrium (LA). LA functional analysis and measurement have an essential role in cardiac function evaluation. Left atrial size and function are key elements during the noninvasive analysis of diastolic function in several heart diseases. The LA represents a “neuroendocrine organ” with high sensitivity to the nervous, endocrine, and immune systems. New insights highlight the importance of left atrial structural, contractile, and/or electrophysiological changes, introducing the concept of “atrial cardiomyopathy”, which is closely linked to underlying heart disease, arrhythmias, and conditions such as aging. The diagnostic algorithm for atrial cardiomyopathy should follow a stepwise approach, combining risk factors, clinical characteristics, and imaging. Constant advances in imaging techniques offer superb opportunities for a comprehensive evaluation of LA function, underlying specific mechanisms, and patterns of progression. In this literature review, we aim to suggest a practical, stepwise algorithm with integrative multimodality imaging and a clinical approach for LA geometry and functional analysis. This integrates diastolic flow analysis with LA remodelling by the application of traditional and new diagnostic imaging techniques in several clinical settings such as heart failure (HF), atrial fibrillation (AF), coronary artery disease (CAD), and mitral regurgitation (MR).
Atopic Dermatitis: Background, Objectives and Future Perspectives (Superresponders)
Authors: Ruiz-Villaverde Ricardo , Domínguez-Cruz Javier , Navarro-Triviño Francisco J. , Galán-Gutiérrez Manuel , Armario-Hita Jose Carlos , Pereyra-Rodriguez Jose Juan
Published: August 2022

In this Special Issue entitled Atopic Dermatitis: New Perspectives, we have tried to collect research of special interest related mainly to the incorporation of pathophysiological aspects and therapeutic novelties in this regard [...]
3-[(1H-Benzo[d][1,2,3]triazol-1-yl)oxy]propyl 9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysene-3a-carboxylate
Authors: Jiang Ai , Anyanwu Margrate , Leong Kafai , Li Jinxin , Gianoncelli Alessandra , Coghi Paolo , Ribaudo Giovanni
Published: August 2022

We herein report on the synthesis of a pentacyclic triterpene functionalized through derivation of betulinic acid with hydroxybenzotriazole. The compound was fully characterized by proton (1H-NMR), carbon-13 (13C-NMR), heteronuclear single quantum coherence (HSQC) and distortionless enhancement by polarization transfer (DEPT-135 and DEPT-90) nuclear magnetic resonance. Ultraviolet (UV), and Fourier-transform infrared (FTIR) spectroscopies as well as and high-resolution mass spectrometry (HRMS) were also adopted. Computational studies were conducted to foresee the interactions between compound 3 and phosphodiesterase 9, a relevant target in the field of neurodegenerative diseases. Additionally, preliminary calculation of physico-chemical descriptors was performed to evaluate the drug-likeness of compound 3.
Silica- Iron Oxide Nanocomposite Enhanced with Porogen Agent Used for Arsenic Removal
Authors: Mladin Georgiana , Ciopec Mihaela , Negrea Adina , Duteanu Narcis , Negrea Petru , Ianasi Paula , Ianași Cătălin
Published: August 2022

This study aims to remove arsenic from an aqueous medium by adsorption on a nanocomposite material obtained by the sol–gel method starting from matrices of silica, iron oxide and NaF (SiO2/Fe(acac)3/NaF). Initially, the study focused on the synthesis and characterization of the material by physico–chemical methods such as: X-ray diffraction, FT-IR spectroscopy, Raman spectroscopy, atomic force microscopy, and magnetization. Textural properties were obtained using nitrogen adsorption/desorption measurements. The zero load point, pHpZc, was also determined by the method of bringing the studied system into equilibrium. In addition, this study also provides a comprehensive discussion of the mechanism of arsenic adsorption by conducting kinetic, thermodynamic and equilibrium studies. Studies have been performed to determine the effects of adsorbent dose, pH and initial concentration of arsenic solution, material/arsenic contact time and temperature on adsorption capacity and material efficiency. Three theoretical adsorption isotherms were used, namely Langmuir, Freundlich and Sips, to describe the experimental results. The Sips isotherm was found to best describe the experimental data obtained, the maximum adsorption capacity being ~575 µg As(III)/g. The adsorption process was best described by pseudo-second order kinetics. Studies have been performed at different pH values to establish not only the optimal pH at which the adsorption capacity is maximum, but also which is the predominantly adsorbed species. The effect of pH and desorption studies have shown that ion exchange and the physiosorption mechanism are implicated in the adsorption process. From a thermodynamic point of view, parameters such as ΔG°, ΔH° and ΔS° were evaluated to establish the mechanism of the adsorption process. Desorption studies have been performed to determine the efficiency of the material and it has been shown that the material can be used successfully to treat a real-world example of deep water with a high arsenic content.