bluuebunny/crossref_metadata_2025 huggingface dataset:
A Dual Beta Blocker and Calcium Channel Blocker Overdose in a Patient with Substance Abuse
Authors: Louie Pulliam Sarah , Lantz Rebekah
Published: August 2023

Aim: Nearly 25% of hospital admissions have related adverse drug events with 6-7% of these related to beta blockers (BB) or calcium channel blockers (CCB). Introduction: In some cases, patients do not report their noncompliance at home as well as their illicit substance use leading to worsened outcomes. We present a case of BB and CCB toxicity with concomitant substance abuse, its treatment and general outcome. Case: A 49-year-old woman with history of diabetes mellitus, stroke, and hypertension presented with flu-like symptoms including fever, nausea, vomiting, diarrhea and dysuria. She was admitted for treatment of urinary tract infection and possible left lower lobar pneumonia with guideline-directed antibiotic and IV fluids for acute kidney injury. She was elusive about her substance use history and endorsed compliance with her cardiac and other medications. Unfortunately, after administration of her morning medications, she had cardiac decline including hypotension and bradycardia with a subsequent hypoglycemia and left sided deficits leading to further investigation into her medication adherence and substance use history. History evolved that she was noncompliant with her high dose cardiac medications and a urine drug screen was positive for amphetamines, barbiturates, and nonprescription benzodiazepines. Treatment: The patient’s shock was treated with resuscitative fluids, glucagon, and calcium infusion as well as a short round of vasopressor. She was transferred to a higher acuity center for large vessel occlusion at the distal portion of the left vertebral artery as seen on stroke imaging. Her blood and urine cultures ultimately grew extended spectrum beta lactamase bacteria, meanwhile her shock was deemed medication-induced hypovolemic shock with a depressed heart rate response given a normal transthoracic echocardiogram and quick resolution after reversal agent. Despite the severity and progression of the hospitalization the patient elected to leave against medical advice (AMA) prior to neurosurgical evaluation and completion of antibiotics. She has since been seen well in follow up by her outpatient provider. Discussion: Cardiac medications are associated with adverse cardiac effects and should be prescribed carefully in patients with substance abuse. Further elucidation of substance abuse led to improved treatment outcomes in this patient with polysubstance and alcohol abuse.
Quality of Life in Patients with Stiff-Person Syndrome: Evaluation Congruent with Patient Values using the Schedule-Direct Weighting Method
Authors: Kobayashi Chiemi , Makihara Yukiko , Nishida Yusuke
Published: August 2023

Patients with chronic progressive disease have a low health-related quality of life (HRQoL); however, various compensation mechanisms can improve and restore quality of life (QoL) even in cases of severe physical disability. In this study, we evaluate QoL according to patient value by individual QoL evaluation and identify QoL determinants in patients with stiff-person syndrome (SPS) to consider appropriate support measures. By 13 December 2020, SPS patients completed semi-structured interviews. For patients, the positive factors were "family support" and "parental care", while the negative factors were "physical symptoms" and "relationship with doctors". Parental care" was identified as the most important area, but satisfaction was low. Therefore, in each case, support is needed to ensure that the patient is satisfactory. In addition, "physical symptoms" are the strongest negative areas and can be alleviated with appropriate medical assistance. In addition, rehabilitation should work on pain relief caused by muscle spasms and stiffness.
Clinical Pharmacology of Gentamicin
Authors: Maria Pacifici Gian
Published: August 2023

Gentamicin is an important agent for the treatment of many serious gram-negative bacillary infections. Gentamicin is the aminoglycoside of first-choice because the reliable activity against all but the most resistant gram-negative aerobes. Gentamicin preparations are available for parenteral, ophthalmic, and topical administration. The recommended intramuscular or intravenous dose of gentamicin sulphate for treatment of gram-negative organisms in adults with normal renal function is 5 to 7 mg/kg daily. For patients with renal dysfunction the interval between may be extended. The efficacy and safety of gentamicin have been reported but gentamicin may induce nephrotoxicity and/or ototoxicity in some patients. Gentamicin penetrates in significant amounts into bone, skeletal muscle, wound tissue, ischemic foot ulcers, and in subcutaneous tissue. The pharmacokinetics of gentamicin have been studied in febrile neutropenic adult patients and in healthy adult subjects and gentamicin elimination half-life is about 3 hours. The pharmacokinetics of gentamicin have been investigated in tetraplegic and in paraplegic adult patients and in healthy adult subjects and the elimination half-life of gentamicin is about 2 hours. The prophylaxis, treatment, and trials with gentamicin have been extensively reported. Gentamicin penetrates into the cerebrospinal fluid in significant amounts and treats bacterial meningitis in infants. Gentamicin is poorly transferred across the human placenta and poorly migrates into the breast-milk. The aim of this study is to review gentamicin efficacy and safety, toxicity, diffusion into body-tissues, pharmacokinetics, prophylaxis, treatment, trials, penetration into the cerebrospinal fluid, treatment of bacterial meningitis, transfer across the human placenta, and migration into the breast-milk.
A Vaccine for HIV
Authors: Kleinman Alan
Published: August 2023

HIV has been infecting people for more than 30 years. The viral genetic sequence is well known including viral proteins produced. Why haven't any successful vaccines for this infection been produced despite all this time passing and all this understanding of the virus? This paper presents the problems associated with the production of a useful vaccine, not just for HIV but for many other diseases as well.
Platelet-Rich Plasma Injection Versus Combined Fractional Carbon Dioxide Laser with Platelet-Rich Plasma in Treatment of Vitiligo: A Comparative Study
Authors: Ebrahiem El- Shrbeny Yasmen Mohamed , El-Mongy Shaymaa , Mahrous Ghanem Bothyna
Published: August 2023

Vitiligo is an acquired skin disorder characterized by depigmented macules and patches due to the loss of functioning melanocytes in the skin, with a global prevalence around 1%. Vitiligo does not produce direct physical impairment; however, it has a negative social and psychological impact on the afflicted patients when the depigmented lesions occur in exposed areas, such as face, neck, and extremities.
The Design of an ICT Enabled Active Teaching and Learning Model for Use in Teacher Training Institutions in Uganda
Authors:   Nkumba University, Uganda, Mugisha Annet Kajura , Lubega Jude Thedius , Kasujja John Paul
Published: August 2023

In this paper, the author describes the theories behind the model that was designed in a study that was conducted in Eastern Region, Uganda. The paper provides examples of the teaching model based upon the model and illustrates the support systems required to facilitate the implementation of the model. The e-Model for Active Teaching and Learning to enhance the teaching and learning process utilizing technologies as a result of the growing use of technology over the past 10 years has been designed. The e-Model targets the teachers in a bid to improve the learning outcomes. The study design was a mixed method which employed qualitative and quantitative approaches and was conducted in the Eastern Uganda with a total population of 313 participants from the 6 participating teacher training colleges. The findings demonstrated a substantial link between teaching methodologies, ICT tools, and tools for active learning. Using the data collected on the relationship between aspects an e-Model for Active Teaching and Learning (e-MATL), to support teacher educators in effective use of technology to enhance active learning strategies.
Pendampingan Simulasi Asesmen Kompetensi Minimum berbasis Literasi Digital untuk Meningkatkan Kemampuan Literasi Numerasi dan Adaptasi Teknologi Siswa Sekolah Dasar
Authors: Aini Sindi Nur , Agnita Siska Pramasdyahsari
Published: August 2023

Kemampuan literasi dan numerasi adalah sebuah konsep penting yang harus dipahami setiap individu untuk mengembangkan bakat dan sumber daya manusia serta ketrampilan teknologi juga menjadi sebuah elemen yang penting sebagai tuntutan pembelajaran abad ke -21. Rendahnya kemampuan literasi dan numerasi juga ditunjukan berdasarkan hasil observasi yang dilakukan di SD Negeri 2 Semampir yang terletak di Kecamatan Jepon Kabupaten Blora yang menunjukkan kemampuan literasi dan numerasi di sana masih kurang, maka dari itu pengabdian ini bertujuan untuk meningkatkan kemampuan literasi numerasi dan adaptasi teknologi pada sampel tersebut. Metode yang digunakan dalam pengabdian ini adalah deskriptif kualitatif dengan observasi. Hasil dari pengabdian ini yaitu adanya upaya dalam program kampus mengajar untuk meningkatkan kemampuan literasi numerasi serta cakap teknologi yaitu dengan pendampingan simulasi AKM berbasis literasi digital. Hasilnya sebanyak 90% siswa memenuhi indikator pertama, 54% indikator kedua serta 63% memenuhi indikator ketiga. Selain itu, siswa merasa siap dan lihai dalam melaksankan ANBK mendatang karena sudah dibekali oleh simulasi AKM. Siswa juga mengalami peningkatan kemampuan literasi numerasinya serta sudah dapat mengoperasikan laptop.
Sosialisasi Quantitative Strategic Planning Matrix (QSPM) Dalam Strategi Promosi Berbasis Digital Pada Toko Pakaian Muslim Di Kota Padangsidimpuan
Authors: Batubara Hery Dia Anata , Pane Pertama Yul Asmara
Published: August 2023

Pengabdian masyarakat ini bertujuan untuk memperkenalkan dan mensosialisasikan metode Quantitative Strategic Planning Matrix (QSPM) kepada pemilik toko pakaian Muslim di Kota Padangsidimpuan, dengan fokus pada strategi promosi berbasis digital. Melalui kegiatan ini, diharapkan pemilik toko dapat memperoleh pengetahuan dan keterampilan yang diperlukan untuk mengembangkan strategi promosi yang efektif dalam era digital. Kegiatan sosialisasi QSPM dilakukan melalui serangkaian workshop, pelatihan, dan diskusi interaktif. Para peserta akan diperkenalkan dengan konsep dasar QSPM, termasuk langkah-langkah dalam mengidentifikasi faktor-faktor strategis dan memilih alternatif strategi yang tepat. Mereka juga akan mendapatkan contoh aplikasi QSPM dalam konteks toko pakaian Muslim. Hasil dari pengabdian masyarakat ini diharapkan dapat memberikan pemahaman yang lebih baik kepada pemilik toko pakaian Muslim tentang pentingnya strategi promosi berbasis digital dan bagaimana QSPM dapat digunakan sebagai alat untuk mengembangkan strategi yang efektif. Dengan pemahaman ini, diharapkan mereka dapat meningkatkan kehadiran online mereka, memanfaatkan media sosial dan platform digital lainnya, serta meningkatkan daya saing mereka di pasar yang semakin kompetitif. Pengabdian masyarakat ini diharapkan dapat memberikan manfaat nyata bagi pemilik toko pakaian Muslim di Kota Padangsidimpuan. Dengan mengadopsi QSPM dan strategi promosi berbasis digital, diharapkan mereka dapat meningkatkan visibilitas, menarik pelanggan baru, dan memperluas jangkauan pasar mereka. Selain itu, kegiatan ini juga dapat mendorong pertumbuhan ekonomi lokal melalui peningkatan daya saing industri pakaian Muslim di Kota Padangsidimpuan.
Patient-Specific Pain Model for Identifying Patients at Risk Following TKA
Authors: Antunes Ricardo , Jacob Paul , Marchand Bob , Justice Elaine , Taylor Kelly , Hampp Emily , Verstraete Matthias
Published: August 2023

Remote patient monitoring provides clinicians with visibility to patients’ recovery beyond what can be achieved with in clinic visits alone. Patients’ pain management is an important aspect of recovery following total knee arthroplasty (TKA), and one that is increasingly tracked remotely through digital applications. Its timely assessment may provide clinicians with a way to detect postoperative complications. We proposed a patient-specific model that predicts the probability of remotely collected pain scores for TKA patients along a 90-day recovery period, aimed at detecting patients with anomalous pain scores, and enable appropriate interventions by clinicians in a timely manner. We fitted and validated the model with a set of 4,782 remotely collected pain scores for 84 patients that underwent unilateral primary TKA.
Sexting is not always wanted: consequences on satisfaction and the role of sexual coercion and online sexual victimization
Authors: Garrido-Macías Marta , Herrera Antonio , Alonso-Ferres María , Herrera M. Carmen
Published: August 2023

The understanding of sexting as a new form of interpersonal communication is increasing; however, little is known about whether the incidence, correlates, and outcomes of sexting vary depending on whether such behavior is done willingly or not. In this non-experimental study, we aimed to investigate the prevalence, predictors, and consequences of sexting among 310 Spanish young adults, who completed an online survey regarding their previous experiences of wanted and unwanted sexting behaviors, their sexual coercion and online sexual victimization experiences, and their levels of sexual and life satisfaction. The results showed that more than half and one third of the sample had been involved in wanted and unwanted sexting behaviors, respectively. Additionally, sexual coercion and online sexual victimization predicted a higher probability of engaging in unwanted sexual behaviors and, with that, a decrease of life satisfaction. Finally, having experienced more instances of sexual coercion was associated with lower life satisfaction by increasing the likelihood of suffering online sexual victimization experiences and engaging in additional unwanted sexting behaviors. Our findings show the importance of discerning between wanted and unwanted sexting and how doing so differently conditions the predictors and consequences of this phenomena.

La comprensión del sexting como una nueva forma de comunicación interpersonal es cada vez mayor; sin embargo, poco se sabe sobre si la incidencia, correlatos y resultados del sexting varían en función de si se realiza de forma voluntaria o no. En este estudio no experimental, nos proponemos investigar la prevalencia, los predictores y las consecuencias del sexting entre 310 jóvenes españoles, que completaron una encuesta online sobre sus experiencias previas de sexting deseado y no deseado, coerción sexual y victimización sexual online, así como sus niveles de satisfacción sexual y vital. Los resultados mostraron que la mitad y un tercio de la muestra habían estado involucrados en comportamientos de sexting deseados y no deseados, respectivamente. Además, la coerción sexual y la victimización sexual online predijeron una mayor probabilidad de participar en conductas sexuales no deseadas y, con ello, una disminución de la satisfacción vital. Por último, haber experimentado mayor coerción sexual se asoció con menor satisfacción vital al aumentar la probabilidad de sufrir victimización sexual online y de participar en conductas adicionales de sexting no deseado. Nuestros hallazgos muestran la importancia de discernir entre el sexting deseado y el no deseado y cómo el hacerlo de forma diferente condiciona los predictores y las consecuencias de este fenómeno.
EXERGETIC ANALYSIS OF THE SOYBEAN DRYING PROCESS WITH SOLAR ENERGY IN HOT-HUMID CLIMATES
Authors: ACOSTA ISRAEL , CASTILLO  TELLEZ MARGARITA
Published: August 2023

Recently, solar dryers research has focused on determining the drying kinetics and its description from mathematical models; however, exergetic studies are relatively limited. Theoretical and experimental studies are required to break the knowledge barrier with this approach, assessing the maximum potential useful work wasted (exergy loss) by a system as it equilibrates with a reference environment (environment). Through the instrumentation of cabinet–type solar dryers, this work presents the exergetic analysis to evaluate the heat and mass transfer processes of soybean in hot-humid climates. The thermal performance of solar dryer with natural and forced convection was compared. The behavior of irradiance, ambient temperature, and relative humidity and their relationship with weight loss were analyzed. For natural and forced convection, the average exergetic efficiencies were 47.40% and 53.67%, respectively. Sustainability indicators were estimated: improvement potential, sustainability index, and wasted energy ratio. The exergetic performance was better in the process with forced convection compared to natural

Keywords: Exergetic analysis, Solar drying technologies, Sustainability indicators.
PERFORMANCE DESIGN OF A SMOKE CONTROL SYSTEM FOR THE BRIDGE PAVILION
Authors: PEREZ CEBRIAN ALFONSO , LAGO PORTO MERCEDES
Published: August 2023

The Bridge Pavilion designed by Zaha Hadid for the International Exposition of Zaragoza in 2008, is a singular construction declared an Asset of Cultural Interest (BIC) by the Government of Aragon. It is a 280-metre-long building overlooking the Ebro River. Initially, the central nucleus was an exterior space with no fire load, whose lateral envelopes were open and perforated. The change of activity to be developed, as an exhibition and museum area with vehicles, required the enclosure of this volume. The uniqueness of the building makes it impossible to comply with the fire safety requirements (CTE DB SI), therefore, alternative solutions were used for the design of the new smoke control system for the enclosed volume for the new activity. The system selected includes an airlock-extract combination that improves the conditions of evacuation without affecting the aesthetics of the Pavilion's envelope. SODECA fume extractor model THT-56-4T-1-F400 with a theoretical flow rate of 12,349 m³/h, connected to COLT KAMALEON airlock 1500x1000 mm, with an opening degree of 45º, aerodynamic surface area 0.519 m²/m².. The new measures were implemented in the building with the approval of the competent authority for Civil Protection, Cultural Heritage and a favorable final report from an Administration Control Entity.

Keywords: Building Evacuation, Fire Safety Engineering, Alternative Solutions. Performance Based Design, Smoke Control
DEVELOPMENT AND VALIDATION OF AN AUTOMATIC MANUFACTURING PROCESS FOR FIBERGLASS COMPOSITES
Authors: Goenaga Goicoechea Garazi , GUTIERREZ  PEREZ DE EULATE NATALIA , URRUTXUA ANDIA MAITANE , ESNAOLA ARRUTI ARITZ , VALLEJO RASERO FRANCISCO JAVIER
Published: August 2023

Fiberglass reinforced polymeric composites are ideal for various applications due to their mechanical properties and lightweight. However, nowadays many fiberglass reinforced composite manufacturing processes are manual, which makes it complicated for them to meet industrial requirements regarding the quality and reliability of the manufactured parts, limiting their applications. The development of automatic and digital processes lead to the reduction of manual labour and, as a consequence, the cost and variability of the process. Nevertheless, the industrial implementation of these automatic processes requires them to be economically affordable, flexible and simple. Therefore, the research work carried out has focused on the development of an automatic fiberglass composite manufacturing process able to produce composites with mechanical properties comparable to those obtained in conventional manufacturing processes. For this purpose, a two-stage manufacturing line has been developed: (i) the automatic manufacture of fiberglass and ultraviolet (UV) resin prepregs, and (ii) the compaction and curing of these prepregs. The process has been validated by measuring the physical and mechanical properties of the manufactured composites and comparing them to those obtained with hand lay-up and infusion processes.

Key Words: Automatic process, fiberglass, prepregs, UV curing, energy efficiency, productive efficiency.
SOLID STATE BATTERIES: CHALLENGES AND PROJECTION (Part 2/2)
Authors: Babaei Azin , LLOPIS SEBASTIAN , ZUBIZARRETA SAENZ DE ZAITEGUI LEIRE , GIL AGUSTI MAYTE , GARCIA GARCIA MARTA , QUIJANO LÓPEZ ALFREDO
Published: August 2023

This article reviews the current status and future prospects of solid-state batteries. The study focuses on the description of the challenges and needs for the technological development of solid-state batteries and the research aimed at solving current and future challenges. Finally, the projects related to this type of technology within the Horizon 2020 programme are reviewed.
COMPARATIVE STUDY ON THE GIRDER ERECTION SCHEME FOR THE CHIBI YANGTZE RIVER HIGHWAY BRIDGE
Authors: She Qincong , Yan Donghuang , Chen Changsong , Ma Yining , Huang Gen
Published: August 2023

The construction process of composite cable-stayed bridges varies, and it closely affects the finished bridge. This study takes the Chibi Yangtze River Highway Bridge, which is the world's largest-span composite cable-stayed bridge, as an example in determining the optimal scheme of girder erection during the construction of the composite cable-stayed bridge. Six girder construction schemes were proposed for comparison and analysis. On the basis of satisfying the objective principles of the finished bridge, the stress safety principle, and the economic principle, qualitative and quantitative methods were used to analyze the girder erection schemes. The refined model of the composite girder segment was established by the finite element software ABAQUS to examine the local stress of the bridge. Subsequently, the optimal scheme of girder erection was determined. Then, the key calculation results of the optimal scheme of girder erection during the construction stages and for the finished bridge were given, which proved the feasibility, safety, economy, and controllability of the proposed optimal scheme. Results show that the measured data of the girder line shapes and the cable forces of the finished bridge agree well with the theoretical values. This agreement verifies the correctness of the determination and demonstration of the proposed optimal scheme. This study provides a certain reference for the determination of the girder erection scheme of composite cable-stayed bridges.

Keywords: Composite girder; cable-stayed bridge; steel girder erection; single segment one cycle; two segments one cycle; construction process;
PENGEMBANGAN MODEL PEMBELAJARAN MENGGUNAKAN E-LEARNING UNTUK KETERAMPILAN PROSES BELAJAR IPA
Authors: HARYATI HARYATI , SUNINGSIH SUNINGSIH , ROSYANTI ROSYANTI , PURWANDARI KIKI , DWI DAMAYANTI ARUM , ASTUTI DEWI , SARI DEWI RATNA
Published: August 2023

Penguasaan kompetensi keterampilan proses IPA diperlukan umpan balik yang berkesinambungan. Penggunaan e-learning menjadi alternatif dalam mengatasi keterbatasan waktu pada pembelajaran tatap muka. Penelitian ini bertujuan untuk mengembangkan model pembelajaran yang terintegrasi pada E-learning untuk keterampilan proses IPA. Metode penelitian yang digunakan adalah  metode penelitian dan pengembangan yang mengacu pada pendekatan penelitian dan pengembangan Willis yang terdiri dari tiga tahapan: analisis kebutuhan, pengembangan dan evaluasi. Pada disetiap tahapan dikombinasikan dengan model model 4C & DO untuk mengembangkan bahan pembelajaran. Evaluasi formatif dimulai dari evaluasi ahli, uji coba perorangan dan kelompok kecil yang bertujuan untuk menilai kelayakan produk pembelajaran yang dikembangkan. Hasil penelitian menunjukkan nilai rata-rata ahli materi 3.6 yang berarti produk tersebut dinilai baik, ahli bahasa 3,9 yang berarti produk tersebut baik, ahli desain pembelajaran 3,5 yang berarti produk tersebut baik, dan ahli media 3,4 yang berarti produk tersebut dinilai baik. Kemudian pada tahap uji coba terhadap peserta didik hasil rata-rata untuk tahap uji perorangan 3,8 yang berarti produk tersebut dinilai sangat baik  dan pada tahap ini uji coba uji lapangan 3.7 dianggap baik. Hasil pre test dan post test menunjukkan peningkatan presentase ketuntasan hasil belajar peserta didik sebesar 37,5%. Sehingga dapat disimpulkan pengembangan model pembelajaran menggunakan E-learning efektif untuk meningkatkan keterampilan proses IPA.
MENINGKATKAN IQ PAUD MELALUI BACA LITERASI DAN BERMAIN PERAN DI RA.AL-MUNAWAROH KAMPUNG BOJONGKONENG TELAGA MURNI
Authors: MUSAROFAH MUSAROFAH
Published: August 2023

Baca tulis literasi perlu diajarkan sejak usia dini untuk meningkatkan IQ nya, dengan bermain peran dapat menumbuhkan keceriaan, pengetahuan yang luas dan wawasan berbahasa. Tujuan penelitian deskriptif menggunakan pendekatan kualitatif dengan teknik pengumpulan data yaitu wawancara, observasi dan dokumentasi. Tujuan baca literasi dan bermain peran disamping dapat meningkatkan kemampuan berbahasa anak usia dini, melatih bicara anak, menyimak peran yang sedang dimainkan seperti menirukan suara binatang dan tokoh peran. Tetapi juga dapat meningkatkan IQ anak usia dini. Hasil penelitian literasi baca yang diterapkan di PAUD untuk meningkatkan kemampuan berbahasa anak usia 4-6 tahun yang dilakukan di RA. Al-Munawaroh Kampung Bojongkoneng Telaga Murni sudah terlaksana dengan baik. Hal ini terlihat dari kemampuan berbahasa anak yang telah dicapai diantaranya: anak sudah bisa mengucapkan kata dengan tepat, anak juga dapat mengenal istilah baru (kata baru yang didengarnya), anak dapat mengenal simbol huruf, anak dapat menghubungkan kata dengan gambar, anak dapat menyambungkan garis putus-putus pada huruf, anak dapat mendengarkan cerita atau dongeng dan menceritakan kembali isi cerita secara sederhana, anak dapat menirukan suara tokoh-tokoh dalam cerita atau dongeng dan anak dapat membedakan suara masing-masing tokoh dalam cerita atau dongeng.
Rancang Bangun Media Pembelajaran Mikrokontroller Berbasis Augmented Reality (AR)
Authors: Mukhlisin Mukhlisin , Gani Hamsu Abdul , Purnamawati Purnamawati , Muhammad Umar
Published: August 2023

Teknologi computer vision yang merupakan cabang dari kecerdasan buatan atau artificial intelligence berkembang sangat cepat. Dengan memanfaatkan komputer, dapat dibuat sangat banyak produk-produk berbasiskan teknologi. Salah satunya yaitu teknologi Augmented Reality (AR). Saat ini penggunaan teknologi AR telah banyak dimanfaatkan dalam berbagai bidang salah satunya bidang pendidikan. Tujuan penelitian ini adalah mengetahui desain dan bentuk media pembelajaran mikrokontroller berbasis arduino yang dapat digunakan pada kegiatan pembelajaran. Metode penelitian yang digunakan adalah  metode  ekperimen.  Pengujian  dilakukan  dengan  melakukan  pengukuran  jarak  dan  sudut  keterbacaan  kamera terhadap marker objek AR. Hasil penelitian menunjukkan jarak ideal yang dapat dideteksi oleh kamera berada pada jarak 10  –  60  cm.  Sedangkan  sudut  ideal  yang  dapat  dideteksi  oleh  kamera  berada  pada  sudut  90º  –  170º.  Hasil  pengujian keseluruhan tampilan program aplikasi menunjukkan hasil yang baik.
Implementasi Sistem Monitoring COS φ Sebagai Kendali Konsumsi Daya Reaktif Berlebih
Authors: B Hendri , Prasetia Abdul Muis
Published: August 2023

Pada suatu sistem jaringan instalasi suatu perusahaan produk atau industri tidak menutup kemungkinan untuk mengkonsusmsi beban yang sangat besar. sebagian besar industri memiliki mesin produksi berkapasitas beban yang sangat besar terutama beban induktif. beban induktif sangat berpengaruh pada kualitas φ di sistem jaringan yang akan mengakibatkan kerugian besar baik itu dari pihak PLN (Perusahaan Milik Negara) maupun dari pihak industri. Dari hal tersebut, perlu dilakaukan pemonitoringan nilai cos φ. Selain itu juga perlu dilakukan solusi agar beban reaktif pada industri tersebut tidak melampaui batas yang telah di tetapkan PLN. Dalam penelitian ini telah dilakukan pemonitoringan cos φ pada sistem kemudian akan memutus beban dengan mengontrol sircuit breaker ketika cos φ diketahui melampaui batas yang telah ditentukan yaitu 0,85. Pada penelitian yang saya terapkan ketika cos φ jatuh sebesar 0,76 ketika daya reaktif terputus maka cosphi kembali normal sebesar 0,86. Relay tersputus menyesuaikan seberapa besar nilai cos φ yang jatuh.
Pemanfaatan Framework Codeigniter Pada Aplikasi Pembayaran Air Sumur Bor
Authors: Tahir Tamus Bin , Rais Muhammad
Published: August 2023

Penelitian ini bertujuan untuk merancang dan membuat aplikasi yang dapat mengelola data transaksi pembayaran air sumur bor dari pelanggan, serta mengelola pembuatan laporan transaksi. Pemilihan framework codeigniter karena memiliki banyak library yang sangat mempermudah dalam membuat sebuah aplikasi. Metode pngujian pada sistem ini menggunakan pengujian black box yang bertujuan untuk mengetahui fungsi-fungsi yang tidak berjalan dengan baik atau error dari suatu sistem. Dari hasil pengujian pada modul-modul pada sistem ini yaitu login, user, tarif, pelanggan, pembayaran, dan laporan secara keseluruhan dapat berfungsi dengan baik. Dengan demikianaplikasi ini dapat digunakan oleh usaha pembayaran sumur air bor.
Perancangan Sistem Monitoring Penggunaan Daya Listrik Dan Load Controller Menggunakan Mikrokontroller
Authors: Muhammad Umar , Darwis Rendra
Published: August 2023

Ditengah krisis listrik seperti saat ini konsumen juga harus turut berperan aktif membantu PLN dalam hal ini sebagai pengatur listrik di Indonesia agar tidak terjadi pemadaman bergilir dalam waktu lama karena kurangnya pasokan listrik. Oleh karena itu,  konsumen harus mengatur pemakaian listrik seoptimal mungkin. Sehingga perlu adanya suatu sistem yang dapat membantu dalam mengamati penggunaan daya listrik. Dengan demikian kami merancang sistem monitoring dan control beban yang dapat di jadwalkan. Sistem ini dapat memberikan informasi mengenai penggunaan daya dan mengendalikan beban sesuai jadwal yang telah ditentukan secara otomatis,sehingga pengunaa daya listrik bisa lebih efisien.
SAÚDE DA MULHER NO ESTADO DO TOCANTINS: UM ESTUDO EPIDEMIOLÓGICO SOBRE O CÂNCER DE MAMA
Authors: Nayanne Hardy Lima Pontes  , Ayla Cristina Duarte Neiva  , Daiene Isabel da Silva Lopes  , Durval Nolasco das Neves Neto
Published: August 2023

Apesar dos avanços na saúde pública no que tange a saúde da mulher, o câncer de mama ainda é uma neoplasia incidente na população feminina. O Tocantins é o estado mais novo da federação e estudos que evidenciem particularidades epidemiológicas sobre saúde da mulher são necessários. Nesse sentindo, o objetivo desse estudo foi evidenciar o perfil de mulheres acometidas pelo câncer de mama entre os anos de 2013 a 2021 utilizando como referência o banco de dados do DataSUS. Nossos resultados evidenciaram que no período estudado cerca de 4% dos casos pertenciam ao norte do país, no qual a faixa etária mais acometida foi entre 35 a 69 anos, com o maior índice entre 50 a 59 anos apresentando 4.101 casos (27,72%) seguido por 40 aos 49 anos e 60 a 69 anos com 4.079 casos (25,57%) e 2.772 casos (18,73%), respectivamente. Além disso, o estado do Tocantins totalizou 1.498 casos de câncer de mama, em que a faixa etária entre 50 aos 69 anos foi responsável por 687 casos (45,86%) e entre 40 aos 49 anos culminou em 416 casos (27,77%). Ademais, foram realizadas 99.545 mamografias no estado no período de estudo a fim de se obter o diagnóstico de câncer de mama. Em adição, uma mortalidade de 7,5 de mortes a cada 100.000 mulheres entre os anos.  Em conclusão, apesar do câncer de colo de útero ser descrito como o mais incidente na região, faz-se necessário políticas públicas que incorporem medidas de promoção e prevenção à saúde da mulher no que tange o rastreio do câncer de mama na população do estado.

Palavras-chave: Câncer de mama. Tocantins. Saúde da mulher.
PENGARUH KOMPETENSI DAN DISIPLIN KERJA TERHADAP KINERJA PEGAWAI DI UPT PUSKESMAS KARANGANYAR KABUPATEN LEBAK
Authors: Didi Wandi  , Ahmad Maulana Hakiki
Published: August 2023

Penelitian ini, dapat diambil kesimpulan sebagai berikut,  Rata-rata tanggapan responden atas variabel kompetensi dalam keadaan tinggi, dimana nilai rata-rata skor jawaban responden sebesar 3,822 berada pada skala 3,41-4,20, tanggapan responden atas variabel kinerja dalam keadaan tinggi, dimana nilai rata-rata skor jawaban responden sebesar 3,850 berada pada skala 3,41-4,20, tanggapan responden atas variabel kinerja dalam keadaan tinggi, dimana nilai rata-rata skor jawaban responden sebesar 3,850 berada padaskala 3,41-4,20. Hasil pengujian didapatkan bahwa Kompetensi tidak berpengaruh signifikan terhadap kinerja Pegawai Di UPT Puskesmas Karanganyar Kabupaten Lebak. Pengujian didapatkan bahwa disiplin kerja berpengaruh signifikan dan positif terhadap kinerja Pegawai di UPT Puskesmas Karanganyar Kabupaten Lebak. Sedangkan hasil pengujian didapatkan bahwa kompetensi dan disiplin kerja secara bersama-sama berpengaruh terhadap kinerja pegawai di UPT Puskesmas Karanganyar Kabupaten Lebak.
MEKANISME CORPORATE GOVERNANCE: DAMPAKNYA PADA PEMBENTUKAN INTELLECTUAL CAPITAL PERUSAHAAN INDEKS LQ45
Authors: Yulaikah  , Indah Purnamasari Mutiara , Mujianing Shalwa Renata
Published: August 2023

Penelitian ini bertujuan untuk menguji pengaruh corporate governance yang diproksi dengan struktur kepemilikan saham institusional maupun manajerial dan komposisi komisaris independen terhadap intellecetual capital. Objek penelitian dilakukan pada perusahaan yang terdafar pada indeks LQ45 dengan jumlah sampel diambil 19 perusahaan. Analisis data menggunakan metode regresi linier berganda yang diolah dengan program SPSS. Berdasarkan hasil uji statistik diperoleh hasil 1) Kepemilikan institusional berpengaruh positif dan signifikan terhadap intellectual capital dibuktikan dengan nilai koefisien regresi 0,564 dan signifikasi 0,025. 2) Kepemilikan manajerial tidak berpengaruh terhadap intellectual capital dibuktikan dengan nilai koefisien regresi 0,061 dan signifikasi 0,294. 3) Komisaris independen berpengaruh positif dan signifikan terhadap intellectual capital dibuktikan dengan nilai koefisien regresi 0,806 dan signifikasi 0,047.
PENGARUH KOMUNIKASI INTERPERSONAL, TEAMWORK TERHADAP KINERJA KARYAWAN DI PT LUHAI INDUSTRIAL
Authors: Romli Ahmad , Irawan
Published: August 2023

Kinerja karyawan diasumsikan secara signifikan dipengaruhi oleh komunikasi interpersonal, teamwork yang berkaitan dengan organisasi. studi kausal yang dilaporkan di sini bertujuan untuk menguji hipotesis. itu dilakukan melalui survei di pt luhai industrial, terhadap sampel 53 karyawan dengan metode boring sampling. data untuk setiap variabel dikumpulkan secara terpisah oleh responden yang mengisi kuesioner. teknik jalur diterapkan untuk menganalisis data yang sebelumnya diperlakukan dengan prosedur regresif dan korelasi. hasilnya membuktikan bahwa kinerja karyawan secara langsung dipengaruhi oleh komunikasi interpersonal dan teamwork. temuan menunjukkan bahwa variasi kinerja karyawan telah dipengaruhi oleh komunikasi interpersonal dan teamwork dalam organisasi. ini lebih lanjut menyiratkan perlunya untuk mempertimbangkan variabel kinerja karyawan, komunikasi interpersonal, dan teamwork dalam perencanaan strategis pengembangan sumber daya manusia di pt luhai industrial yang diteliti.
PENGARUH PENERAPAN ORIENTASI LAYANAN PELANGGAN DAN MOTIVASI PELAYANAN PUBLIK TERHADAP KINERJA PEGAWAI BIDANG KESEHATAN LINGKUNGAN
Authors: Hari Lusinto Widodo
Published: August 2023

Konsep New Public Management (Manajemen Publik Baru) meliputi Penerapan Motivasi Pelayanan Publik atau yang dikenal Public Service Motivation (PSM) dan orientasi layanan pelanggan atau Customer Service Orientation (CSO), Penerapan Orientasi Layanan Pelanggan dan Motivasi Pelayanan Publik pada Sektor Publik belum banyak dilakukan, termasuk di Pemerintah Pusat dan Pemerintah daerah di Indonesia. Oleh karena itu penelitian ini berfokus kepada penerapan pada sektor Pemerintahan Bidang Kesehatan Lingkungan pada Dinas Kesehatan Pemerintah Kota Tangerang Selatan, Indonesia. Berdasarkan perkembangan terkini, Penelitian Orientasi layanan pelanggan dan Motivasi Pelayanan public terhadap Kinerja PNS di Unit kerja pelayanan publik di Kota Tangerang Selatan Indonesia belum pernah dilakukan, hal ini merupakan sebab utama mengapa kajian kuantitatif ini dijalankan. Sampel dalam penelitian ini sebanyak 56 (lima puluh enam) orang PNS yang bekerja dibidang Pelayanan publik di Unit Kerja masing-masing. Jenis penelitian ini termasuk penelitian kuantitatif menggunakan Metode Bawang Penelitian, dan Model SEM-PLS (Structural Equation Modeling - Partial Least Square). Kajian ini menunjukan bahwa terdapat 12 dimensi yang mengandungi variabel Orientasi layanan pelanggan, variabel Motivasi Pelayanan publik dan Variabel Kinerja PNS. Hasil kajian menunjukkan bahwa Orientasi Layanan Pelanggan mempunyai pengaruh positif dan signifikan terhadap Kinerja PNS. Kedua, Orientasi Layanan Pelanggan mempunyai pengaruh positif dan signifikan terhadap Motivasi Pelayanan Publik. Ketiga, Motivasi Pelayanan Publik mempunyai pengaruh positif dan signifikan terhadap Kinerja PNS. Orientasi Layanan Pelanggan mempunyai pengaruh tidak langsung dan signifikan terhadap Kinerja PNS melalui Variabel Motivasi Pelayanan publik sebagai variabel Mediasi. Pengaruh Total Hubungan antara Orientasi Layanan Pelanggan dan Kinerja PNS dengan Motivasi Pelayanan Publik sebagai variabel mediasi: menunjukkan bahwa total hubungan merupakan hubungan Partial Mediation.
Halal Tourism: Trend, Opportunities, Challenges and Impact of Halal Tourism on Conventional Tourism
Authors: Muharis  , M. Saidi  , Dani Alfatwari  , Ahmad
Published: August 2023

This study aims to analyze and find out how the trend of halal tourism in the West Nusa Tenggara region and its impact on conventional tourism is investigated. The results of this study show first, the trend of halal tourism in terms of opportunities and challenges, the opportunity for halal tourism in West Nusa Tenggara is very large seeing the intensity of visits every year is so high, especially middle eastern tourists. This is a business investment opportunity for the country's economic income. However, regulations on aspects of halal certification for accommodation and tourism products such as hotels, restaurants and cafes are still an obstacle in the development of halal tourism. Secondly, the presence of halal tourism does not necessarily change and shift pre-existing conventional tourism, but halal tourism is present as a complement and supporter in the expansion of services and facilities to tourists who visit both in terms of accommodation and all the needs of tourists in general.
Improving Local Economy Through Independent Enterpise Community (KUM); Rempung, Indonesia
Authors: Muh Hilmi Pauzi  , Budi Setiawan
Published: August 2023

The research aimed to determine the role of community microeconomic programs in local enterprise community in Rempung with qualitative research approach. The finding shows that the implementation of microeconomic programs channelled through the program of local enterprise community reflected in three pillars. First, KUM activities function as a forum that provides capital loans to local communities. Second, the KUM program is a place of learning to get training and coaching in the developed business units. Third, KUM activities as a forum to develop business partnerships. The significant impact of the independent business group (KUM) program launched by the government can (a) create job opportunities for the community, (b) develop their potential and (c) foster an entrepreneurial spirit.
Factors Affecting Women’s Motivation To Choose Entrepreneurship In East Lombok
Authors: Muh. Fahrurrozi  , M. Juaini  , Heru Cahyono
Published: August 2023

This research aims to examine the effects of self-development factor (X1), family background factor (X2), and income factor (X3) partially and simultaneously on women entrepreneurship in East Lombok. Employing a descriptive quantitative, data are categorized into primary and secondary data. Population in this research is business woman in East Lombok with data sample as many as 100 people. The data were analyzed by using double linear regression t-test (partial), and f-test (simultaneous) with the regression formula MWB= 13.760 +  0,008 PD + 0,056 KLG + 0,188 PND. The result shows that the self-development variable with significant degree is as many as 0,024, significant family background as many as 0,030 and significant income as many as 0,035. Thus, it can be concluded that income affects women’s motivation of entrepreneurship in Selong District, East Lombok, since the significance value is < 0,05. The degree of F significance is 0,044 with probability 0,05, thus, it is proven that self-development variable, family background variable, and income variable affect the motivation of entrepreneurship (Y). The variable of self-development, family background, and income affect women’s motivation in entrepreneurship in Selong District as many as 56,7 %, while 58% of them are influenced by other factors beyond this research.
Peran dukungan sosial dan penyesuaian diri pada kesejahteraan psikologis mahasiswa tahun pertama di masa pandemi COVID-19
Authors: Rossallina Lia , Rifameutia Tjut
Published: August 2023

Pandemi COVID-19 membuat berbagai pihak melakukan perubahan. Di dunia pendidikan, perubahan yang besar adalah bergantinya metode pembelajaran tatap muka menjadi metode Pembelajaran Jarak Jauh (PJJ). Mahasiswa di tahun pertama perkuliahan, termasuk pihak yang turut terkena perubahan ini. Penelitian ini bertujuan menguji pengaruh penyesuaian diri dalam memediasi hubungan dukungan sosial dan kesejahteraan psikologis. Pengambilan data dilakukan pada mahasiswa angkatan 2020 (N=605), dengan teknik convenience sampling. Hasil uji regresi menunjukkan penyesuaian diri secara signifikan memediasi hubungan dukungan sosial dan kesejahteraan psikologis mahasiswa tahun pertama pada masa pandemi COVID-19. Semakin besar dukungan sosial yang diterima dari orang tua dan teman, maka akan membuat mahasiswa melakukan usaha-usaha penyesuaian diri yang akan berpengaruh terhadap tingkat kesejahteraan psikologis mereka. Terdapat saran yang dapat diperhatikan oleh mahasiswa tahun pertama, saran kebijakan untuk perguruan tinggi, serta saran penelitian selanjutnya yang kami uraikan di penelitian ini.
Resiliensi personal para guru dan dosen semasa COVID-19: Menelaah dampak dari kesehatan fisik, mental, dan finansial
Authors: Saputra Nopriadi , Nugroho Riant , Tuti Retnowati WD
Published: August 2023

Para pendidik merupakan aktor yang berpengaruh dalam suatu masyarakat, karena itu daya tahan atau resiliensi para pendidik semasa musibah COVID-19 adalah penting. Artikel ini berupaya untuk membahas mengenai resiliensi personal dari para guru dan dosen serta menguji secara empirik pengaruh dari kesehatan fisik, mental, dan finansial terhadap resiliensi personal tersebut. Sebanyak 538 orang pendidik yang berpartisipasi sebagai responden. Mereka terdiri dari para guru (51%) dan dosen (49%). Sebagian besar adalah perempuan (59%), berusia kurang dari 46 tahun (93%), berlatar pendidikan S1 dan S2 (68%), memiliki pengalaman kerja lebih dari lima tahun (87%), dan berdomisili di pulau Jawa (87%). Data yang diperoleh diolah dan dianalisis menggunakan PLS SEM dan aplikasi SmartPLS. Hasil analisis menjelaskan bahwa kesehatan mental memainkan peranan mediator dalam hubungan antara kesehatan finansial dan personal resiliensi. Para pendidik di Sumatra mengalami bahwa finansial tidak berpengaruh terhadap personal resiliensi dan kesehatan fisik. Untuk meningkatkan resiliensi masyarakat terhadap krisis COVID-19, dapat diawali dengan inisiatif untuk meningkatkan kesehatan mental para pendidik.
What AlphaFold tells us about cohesin’s retention on and release from chromosomes
Authors: Nasmyth Kim A. , Lee Byung-Gil , Roig Maurici B. , Löwe Jan
Published: August 2023

Cohesin is a trimeric complex containing a pair of SMC proteins (Smc1 and Smc3) whose ATPase domains at the end of long coiled coils (CC) are interconnected by Scc1. During interphase, it organizes chromosomal DNA topology by extruding loops in a manner dependent on Scc1’s association with two large hook shaped proteins called SA (yeast: Scc3) and Nipbl (Scc2). The latter’s replacement by Pds5 recruits Wapl, which induces release from chromatin via a process requiring dissociation of Scc1’s N-terminal domain (NTD) from Smc3. If blocked by Esco (Eco)-mediated Smc3 acetylation, cohesin containing Pds5 merely maintains pre existing loops, but a third fate occurs during DNA replication, when Pds5-containing cohesin associates with Sororin and forms structures that hold sister DNAs together. How Wapl induces and Sororin blocks release has hitherto remained mysterious. In the twenty years since their discovery, not a single testable hypothesis has been proposed as to their role. Here, AlphaFold 2 (AF) three-dimensional protein structure predictions lead us to propose formation of a quarternary complex between Wapl, SA, Pds5, and Scc1’s NTD, in which the latter is juxtaposed with (and subsequently sequestered by) a highly conserved cleft within Wapl’s C-terminal domain (CTD). AF also reveals how Scc1’s dissociation from Smc3 arises from a distortion of Smc3’s CC induced by engagement of SMC ATPase domains, how Esco acetyl transferases are recruited to Smc3 by Pds5, and how Sororin prevents release by binding to the Smc3/Scc1 interface. Our hypotheses explain the phenotypes of numerous existing mutations and are highly testable.
Combinatorial expression of gamma-protocadherins regulates synaptic specificity in the mouse neocortex
Authors: Zhu Yi-Jun , Deng Cai-Yun , Fan Liu , Wang Ya-Qian , Zhou Hui , Xu Hua-Tai
Published: August 2023

During the process of synaptic formation, neurons require not only certain principles for selecting partners to form synapses but also additional mechanisms to avoid undesired cells. However, the means to get around unwanted partners remains largely unknown. In this study, we have identified that the combinatorial expression of clustered protocadherin gammas (γ-PCDHs) is essential in regulating such specificity in the mouse neocortex. Using single-cell sequencing from the 5-prime end, we revealed the combinatorial expression pattern of γ-PCDH variable isoforms in neocortical neurons. Whole-cell patch-clamp recordings demonstrated that increasing the similarity level of this combinatorial pattern in neurons reduced their synaptic connectivity. Our findings reveal a delicate molecular mechanism for assembling the neural network in the mouse neocortex.
Structural basis for kinase inhibition in the tripartite E. coli HipBST toxin-antitoxin system
Authors: Bærentsen René L. , Nielsen Stine Vang , Skjerning Ragnhild Bager , Lyngsø Jeppe , Bisiak Francesco , Pedersen Jan Skov , Gerdes Kenn , Sørensen Michael A. , Brodersen Ditlev. E.
Published: August 2023

Many bacteria encode multiple toxin-antitoxin (TA) systems targeting separate, but closely related, cellular functions. The toxin of the
E. coli hipBA
system, HipA, is a kinase that inhibits translation via phosphorylation of glutamyl-tRNA synthetase. Enteropathogenic
E. coli
(EPEC) O127:H6 encodes the
hipBA
-like, tripartite TA system;
hipBST
, in which the HipT toxin specifically targets the tryptophanyl-tRNA synthetase, TrpS. Notably, in the tripartite system, the function as antitoxin has been taken over by the third protein, HipS, but the molecular details of how activity of HipT is inhibited remain poorly understood. Here, we show that HipBST is structurally different from
E. coli
HipBA and that the unique HipS protein, which is homologous to the N-terminal subdomain of HipA, inhibits the kinase through insertion of a conserved Trp residue into the active site. We also show how auto-phosphorylation at two conserved sites in the kinase toxin serve different roles and affect the ability of HipS to neutralize HipT. Finally, solution structural studies show how phosphorylation affects overall TA complex flexibility.