bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of Severity of Infectious Pneumonia for Newborn Using Ultrasound Image under Adaptive Image Denoising Algorithm
Authors: Liu Jieqiong , Lei Tingting , Wu Fengyun
Published: September 2021

This study was to analyze the ultrasound imaging characteristics of infectious pneumonia of newborn in different conditions and the differences in neurobehavioral development. An adaptive image denoising (AID) algorithm was constructed based on multiscale wavelet features. It was compared with the transform domain denoising (TDD) algorithm and spatial domain denoising (SDD) algorithm and applied to ultrasound images of newborns with infectious pneumonia. It was found that the peak signal-to-noise ratio (PSNR), structural similarity (SSIM), and feature similarity index (FSIM) of the constructed algorithm were higher than those of the TDD and SDD algorithms (

P
<
0.05

). The ultrasound scores of newborns in noncritical group (group A, 1.54 ± 0.62 scores) were all lower than those of the critical group (group B, 3.96 ± 0.41 scores) and extremely critical group (group C, 4.25 ± 0.35 scores) (

P
<
0.05

). The behavioral ability, passive muscle tension, active muscle tension, and original reflection of the newborns in group A were better than other groups (

P
<
0.05

). It indicated that the constructed algorithm showed better denoising effect on ultrasound images, which could effectively evaluate the severity of newborns’ infectious pneumonia.
Concurrent Angiomyolipoma and Clear Cell Renal Cell Carcinoma in the Same Kidney: A Rare Finding in a Patient without Tuberous Sclerosis
Authors: Fekkar Amal , Znati Kaoutar , Zouaidia Fouad , Elouazzani Hafsa , Bernoussi Zakia , Jahid Ahmed
Published: September 2021

Synchronous renal cell carcinomas (RCC) and angiomyolipomas (AML) occurring in the same kidney are rare. Cases in the setting of tuberous sclerosis (TS) have been reported in the literature. However, the association of these tumors in the same kidney without TS is even more rare. We report here a case of a clear cell renal cell carcinoma (CCRCC) associated with an AML in the same kidney in a 42 years old female lacking the TS diagnostic criteria. The patient underwent a radical nephrectomy. Six months after surgery, the patient is healthy without signs of tumor recurrence or distant metastasis.
Anomalous Left Coronary Artery Connected to the Pulmonary Artery in a 15-Year-Old Girl: Case Report and Discussion on Secondary Prevention of Sudden Death
Authors: Laïk Jérémy , Fouilloux Virginie , Aldebert Philippe , Koutbi Linda , Hourdain Jérôme , De Swardt Philippe , Tiger Fabrice , Bellemain-Appaix Anne , Bernasconi François , Jacq Laurent
Published: September 2021

Background. Anomalous left coronary artery connected to the pulmonary artery (ALCAPA) is a rare congenital heart disease. Adaptive development of sufficient heterocoronary collaterality in the newborn may allow survival to a later age. In older children or adults, malignant ventricular arrhythmias can reveal the disease. Case Report. A 15-year-old girl was referred to the local hospital after a resuscitated out-of-hospital cardiac arrest. CT scan and coronary angiography revealed an ALCAPA. Direct aortic reimplantation of the left coronary artery was performed. Postoperative ECG monitoring showed short episodes of nonsustained ventricular tachycardia. Transthoracic echocardiography and cardiac MRI revealed subendocardial fibrosis of the anterolateral papillary muscle. Beta-blockade therapy was initiated at first intention. After hospital discharge, the patient reported several fainting without loss of consciousness. Considering sudden death nonrelated to effort, episodes of nonsustained ventricular tachycardia, and areas of myocardial fibrosis, the patient underwent subcutaneous cardioverter-defibrillator implantation. 6-month follow-up is satisfactory without clinical or rhythmic abnormalities. Discussion. Indication for surgical correction of ALCAPA is well defined, but rhythmic secondary prevention after resuscitated cardiac arrest is less consensual. Cardiac MRI is an essential tool in the identification of a potential rhythmic substrate and should be taken into account in the discussion of a preventive cardioverter-defibrillator implantation.
A Joint Optimization Model of (s, S) Inventory and Supply Strategy Using an Improved PSO‐Based Algorithm
Authors: Deng Huayang , Shi Quan , Wang Yadong
Published: September 2021

This paper mainly discussed the problem of a multiechelon and multiperiod joint policy of inventory and supply network. According to the random lead time and customers’ inventory demand, the (s, S) policy was improved. Based on the multiechelon supply network and the improved, the dynasty joint model was built. The supply scheme in every period with the objective of minimum total costs is obtained. Considering the complexity of the model, the improved particle swarm optimization algorithm combining the adaptive inertia weight and grading penalty function is adopted to calculate this model and optimize the spare part problems in various environments.
Application of Aporrectodea caliginosa to Mitigate the Waste and the Effects of Vermicompost on the Exomorphological Features of Phaseolus vulgaris
Authors: Mir Rouf Ahmad , Shrivastava Sarita , Pawaiya Pragya Singh , Samadhiya Hemant
Published: September 2021

Vermin biotechnology is an eco-friendly technique and economically beneficent process to mitigate organic waste. India’s agro-industrial sector contributes colossal wealth of plant materials in the form of compost. The present study aims to publicize soil healthiness and its plant growth supplying possessions further corroborating the use of organic amendments instead of fertilizers. Plastic replicates investigation is an exercise in eighteen replicates in which fifteen were soil amendment treatments: one triplicate-control, 0% vermicompost, 50%, 25%, 12.5%, 6.25%, and 3.125% vermicompost of soil. Containers contained 2 kg soil each, in which seeds are sown, and the measurement of studied traits (length of shoot, length of internodes, flowers, leaves number and number of branches, and rate of germination) was noticed. The earthworms (Eudrilus eugeniae and Aporrectodea caliginosa) feed on waste like broiler droppings, the dung of sheep and cow, leaves, and decomposed wood and convert it into vermicompost, which required 72 days to extenuate the waste. Each setup was conducted on plastic containers, and there would be control and the test at respective experiments. Vermicompost was prepared; obviously, it contains better farming nutrients analyzed by different scientific methods and is very efficient for plant growth and other features. The main objective of the study was the effect of quality vermicompost produced by A. caliginosa on the exomorphology and rate of germination of Phaseolus vulgaris. Different ratios of vermicompost in respective replicates affect plant growth and external morphology, which is directly linked with nutrients present in treated and untreated soil. The outcomes suggested that vermicompost can be overworked as an efficacious biofertilizer.
[Retracted] Experimental Analysis of Mechanical Properties and Durability of Cement‐Based Composite with Carbon Nanotube
Authors: Du Yubing , Gao Peiwei , Yang Jianming , Shi Feiting , Shabaz Mohammad
Published: September 2021

In order to study the mechanical properties and durability of cement‐based composite with carbon nanotube, the test and analysis experiments are designed. Raw materials and related pharmaceutical instruments are prepared, to obtain cement‐based composite with carbon nanotube samples by catalytic pyrolysis according to different proportions. The prepared sample is taken as the experimental object, and different bearing capacities are applied on different positions of the sample, to observe the change of the sample, and then, the experimental results of the mechanical properties of composite materials are obtained. The durability test results are obtained by combining the impermeability and frost resistance of the test object. The average compressive strength is 84.09 MPa, the average flexural strength is 16.9 MPa, and the crack resistance index is 22.5. In addition, the structure and diffusion coefficient of the sample also change in different degrees after the solution immersion and freeze‐thaw treatment. Through longitudinal comparison, the more the carbon nanotubes are added into cement‐based composite, the better its mechanical properties and durability are.
Developing ZNF Gene Signatures Predicting Radiosensitivity of Patients with Breast Cancer
Authors: Yan Derui , Shen Mingjing , Du Zixuan , Cao Jianping , Tian Ye , Zeng Ping , Tang Zaixiang
Published: September 2021

Adjuvant radiotherapy is one of the main treatment methods for breast cancer, but its clinical benefit depends largely on the characteristics of the patient. This study aimed to explore the relationship between the expression of zinc finger (ZNF) gene family proteins and the radiosensitivity of breast cancer patients. Clinical and gene expression data on a total of 976 breast cancer samples were obtained from The Cancer Genome Atlas (TCGA) database. ZNF gene expression was dichotomized into groups with a higher or lower level than the median level of expression. Univariate and multivariate Cox regression analyses were used to evaluate the relationship between ZNF gene expression levels and radiosensitivity. The Molecular Taxonomy Data of the International Federation of Breast Cancer (METABRIC) database was used for validation. The results revealed that 4 ZNF genes were possible radiosensitivity markers. High expression of ZNF644 and low expression levels of the other 3 genes (ZNF341, ZNF541, and ZNF653) were related to the radiosensitivity of breast cancer. Hierarchical cluster, Cox, and CoxBoost analysis based on these 4 ZNF genes indicated that patients with a favorable 4-gene signature had better overall survival on radiotherapy. Thus, this 4-gene signature may have value for selecting those patients most likely to benefit from radiotherapy. ZNF gene clusters could act as radiosensitivity signatures for breast cancer patients and may be involved in determining the radiosensitivity of cancer.
Investigating the Effect of VR + Haptics Approach on Students’ Flow Experience and Outcomes: An Empirical Study on VR Laparoscopy
Authors: Shen Yang , Wang Zhaoxue , Hao Aimin , Yu Peng , Zhai Xuesong , Wang Haipeng
Published: September 2021

Background. Virtual reality‐based surgery training has become a promising trend in the sector of clinical education. Prior studies have confirmed the effectiveness of VR‐based surgical simulators on training surgeons. Most existing papers employing subjective methods explored the students’ overall perceptions of surgical skills. However, few studies, from the multidimension perspective of learning performance, investigate how VR improves surgery skills. Participants. 37 college students were recruited in comparative experimental research. The experimental group was equipped with a VR + haptic surgical simulator, while the VR simulator without haptic feedback was used for the control group. Method. The study resorted to physiological approaches to investigate the influence of the VR laparoscopic surgical training system on students’ performance. Results. The experimental group scored higher than the control group in flow experience and has better performance in the four dimensions of operation evaluation skills. Conclusion. The study deposited that learners are more likely to exert to flow experience in a learning situation with haptic feedback, which will further improve medical students’ performance.
Aconitine Induces TRPV2-Mediated Ca2+ Influx through the p38 MAPK Signal and Promotes Cardiomyocyte Apoptosis
Authors: Yang Chunai , Zeng Xiaoyan , Cheng Zhongfeng , Zhu Junbo , Fu Yangshan
Published: September 2021

Aconitine is the main effective component of traditional Chinese medicine Aconitum, which has been proved to have severe cardiovascular toxicity. The toxic effect of aconitine on cardiomyocytes is related to intracellular calcium overload, but the mechanism remains unclear. The aim of this study was to explore the mechanism of aconitine inducing intracellular Ca2+ overload and promoting H9c2 cardiomyocyte apoptosis through transient receptor potential cation channel subfamily V member 2 (TRPV2). After treated with different concentrations of aconitine, the level of cell apoptosis, intracellular Ca2+, and expression of p-p38 MAPK and TRPV2 of H9c2 cardiomyocytes were detected. The results showed that aconitine induced Ca2+ influx and H9c2 cardiomyocyte apoptosis in a dose-dependent manner and promoted p38 MAPK activation as well as TRPV2 expression and plasma membrane (PM) metastasis. siTRPV2, tranilast, and SB202190 reversed intracellular Ca2+ overload and H9c2 cardiomyocyte apoptosis induced by aconitine. These results suggested that aconitine promoted TRPV2 expression and PM metastasis through p38 MAPK signaling, thus inducing intracellular Ca2+ overload and cardiomyocyte apoptosis. Furthermore, TRPV2 is a potential molecular target for the treatment of aconitine poisoning.
Tumor Biomarker In-Solution Quantification, Standard Production, and Multiplex Detection
Authors: Japp Nicole C. , Souchek Joshua J. , Sasson Aaron R. , Hollingsworth Michael A. , Batra Surinder K. , Junker Wade M.
Published: September 2021

The diagnosis and monitoring of cancer have been facilitated by discovering tumor “biomarkers” and methods to detect their presence. Yet, for certain cancers, we still lack sensitive and specific biomarkers or the means to quantify subtle concentration changes successfully. The identification of new biomarkers of disease and improving the sensitivity of detection will remain key to changing clinical outcomes. Patient liquid biopsies (serum and plasma) are the most easily obtained sources for noninvasive analysis of proteins that tumor cells release directly and via extracellular microvesicles and tumor shedding. Therefore, an emphasis on creating reliable assays using serum/plasma and “direct, in-solution” ELISA approaches has built an industry centered on patient protein biomarker analysis. A need for improved dynamic range and automation has resulted in the application of ELISA principles to paramagnetic beads with chemiluminescent or fluorescent detection. In the clinical testing lab, chemiluminescent paramagnetic assays are run on automated machines that test a single analyte, minimize technical variation, and are not limited by serum sample volumes. This differs slightly from the R&D setting, where serum samples are often limiting; therefore, multiplexing antibodies to test multiple biomarkers in low serum volumes may be preferred. This review summarizes the development of historical biomarker “standards”, paramagnetic particle assay principles, chemiluminescent or fluorescent biomarker detection advancements, and multiplexing for sensitive detection of novel serum biomarkers.
A Risk-Averse Newsvendor Model under Stochastic Market Price
Authors: Zhang Huirong , Zhang Zhenyu , Zhang Jiaping
Published: September 2021

The optimal inventory control is closely related to an enterprise’s operational efficiency, survival, and development. Market price uncertainty is introduced into the newsvendor model and the uncertainty’s impact on the firm's optimal stocking quantity is discussed. The results show that the impact of stochastic market price on the optimal stocking quantity under a given condition mainly depends on the magnitude of inventory cost. When the inventory cost is low, the market price’s uncertainty leads the firm to increase the stocking quantity. In contrast, when the inventory cost is high, market price uncertainty leads the firm to decrease inventory. Besides, the risk-averse behaviour leads the firm to reduce its stocking quantity.
Cancer Etiology and Prevention Principle: “1 + X”
Authors: Liu Hui , Dong Zigang
Published: September 2021

Cancer was previously thought to be an inevitable aspect of human health with no effective treatments. However, the results of in-depth cancer research suggest that most types of cancer may be preventable. Therefore, a comprehensive understanding of the disparities in cancer burden caused by different risk factors is essential to inform and improve cancer prevention and control. Here, we propose the cancer etiology and prevention principle “1 + X,” where 1 denotes the primary risk factor for a cancer and X represents the secondary contributing risk factors for the cancer. We elaborate upon the “1 + X” principle with respect to risk factors for several different cancer types. The “1 + X” principle can be used for precise prevention of cancer by eliminating the main cause of a cancer and minimizing the contributing factors at the same time.
DMRT1: An Ancient Sexual Regulator Required for Human Gonadogenesis
Authors: Zarkower David , Murphy Mark W.
Published: September 2021

Transcriptional regulators related to the invertebrate sexual regulators doublesex and mab-3 occur throughout metazoans and control sex in most animal groups. Seven of these DMRT genes are found in mammals, and mouse genetics has shown that one, Dmrt1, plays a crucial role in testis differentiation, both in germ cells and somatic cells. Deletions and, more recently, point mutations affecting human DMRT1 have demonstrated that its heterozygosity is associated with 46,XY complete gonadal dysgenesis. Most of our detailed knowledge of DMRT1 function in the testis, the focus of this review, derives from mouse studies, which have revealed that DMRT1 is essential for male somatic and germ cell differentiation and maintenance of male somatic cell fate after differentiation. Moreover, ectopic DMRT1 can reprogram differentiated female granulosa cells into male Sertoli-like cells. The ability of DMRT1 to control sexual cell fate likely derives from at least 3 properties. First, DMRT1 functionally collaborates with another key male sex regulator, SOX9, and possibly other proteins to maintain and reprogram sexual cell fate. Second, and related, DMRT1 appears to function as a pioneer transcription factor, binding “closed” inaccessible chromatin and promoting its opening to allow binding by other regulators including SOX9. Third, DMRT1 binds DNA by a highly unusual form of interaction and can bind with different stoichiometries.
Tandem Therapeutic Plasma Exchange Reduces Continuous Renal Replacement Therapy Downtime
Authors: Foglia Matthew J. , Pelletier Jonathan H. , Bayir Hülya , Fleck Annette , Konyk Leslie , McSteen Coleen , Fisher Dawn , Fuhrman Dana Y.
Published: September 2021

Introduction: Continuous renal replacement therapy (CRRT) has become a primary treatment of severe acute kidney injury in children admitted to the intensive care unit. CRRT “downtime” (when the circuit is not active) can represent a significant portion of the prescribed treatment time and adversely affects clearance. The objective of this study was to evaluate factors associated with CRRT “downtime” and to determine whether instituting a tandem therapeutic plasma exchange (TPE) protocol could significantly and robustly decrease circuit downtime in patients receiving both therapies. Methods: This is a retrospective cohort study of 116 patients undergoing CRRT in the pediatric, neonatal, or cardiac ICU at UPMC Children’s Hospital of Pittsburgh from January 2014 to July 2020. We performed multivariable logistic regression to determine factors associated with CRRT downtime. We instituted a tandem TPE protocol whereby TPE and CRRT could run in parallel without pausing CRRT in April 2018. We analyzed the effect of the protocol change by plotting downtime for patients undergoing CRRT and TPE on a run chart. The effect of initiating tandem TPE on downtime was assessed by special cause variation. Results: For 108/139 (77.7%) sessions with downtime data available, the median (IQR) percentage of downtime was 6.2% (1.7–12.7%). Multivariable logistic regression showed that TPE was significantly associated with CRRT downtime (p = 0.003), and that age, sex, race, catheter size, and anticoagulation were not. For patients undergoing TPE, the median (IQR) percentage of downtime was 14.7% (10.5–26%) and 3.4% (1.3–4.9%) before and after initiation of tandem TPE, respectively (p < 0.001). The difference in downtime percentage met criteria for special cause variation. Conclusions: Interruptions for TPE increase CRRT downtime. Tandem TPE significantly reduces CRRT downtime in patients undergoing both procedures concomitantly.
Endoscopic Treatment of an Idiopathic Pancreaticopleural Fistula
Authors: Correia João , Pinho Rolando , Francisco Elsa , Proença Luísa , Fernandes Carlos , Oliveira Manuel
Published: September 2021

A 61-year-old man was diagnosed with an exudative pleural effusion with raised amylase and bilirubin levels. The patient had no previous history of acute pancreatitis or trauma and no clinical or radiological signs of chronic pancreatitis. On thoracoabdominal computed tomography, a pancreatic pseudocyst with a pancreaticopleural fistula was identified. Endoscopic retrograde cholangiopancreatography identified a ductal disruption site in the body of the pancreas. Pancreatic sphincterotomy and stent placement in the duct of Wirsung, combined with medical management, allowed fistula closure, pseudocyst reabsorption, and no relapse of the pleural effusion. The relevance of this case lies not only in its rarity but also as it highlights the importance of a multidisciplinary approach in such uncommon conditions. Optimal management of this condition is debatable due to the absence of prospective studies comparing medical, endoscopic, and surgical approaches.
Congenital Malalignment of the Great Toenail, the Disappearing Nail Bed, and Distal Phalanx Deviation: A Review
Authors: Buttars Benjamin , Scott Steven Gates , Glinka Danielle , Daniel C. Ralph , Brodell Robert T. , Braswell Mark A.
Published: September 2021

Importance: Congenital malalignment of the great toenail (CMGT) is an idiopathic deviation of the nail apparatus. CMGT predisposes patients to recurrent stress forces, microtrauma, and secondary complications. The purpose of this study was to review the current published photographs to determine the relationship between variants of CMGT and the disappearing nail bed (DNB). Observations: A search in PubMed and Google using the terms congenital malalignment of the great toenail, disappearing nail bed, and lateral nail deviation was performed. Of the 53 photographs found in a total of 35 articles, 23 were disqualified due to low picture resolution or poor angle. The remaining 30 photographs were evaluated. Pure nail malalignment with associated dystrophy and DNB was found in 22 of 30 photographs. Four of 30 cases demonstrated pure deviation of the distal phalanx, with nail dystrophy but minimal DNB. The remaining 4 cases demonstrated a combination of toe deviation and nail unit deviation with varying degrees of DNB. Conclusions and Relevance: DNB was associated with all forms of pure CMGT. Moreover, a variant of malalignment of the distal phalanx was noted in 8 photographs. This has potential implications for further studies and treatment to correct secondary complications.
Evaluation and Quantification of Cytomorphometry in Conjunction with Visual Examination and Exfoliative Cytology in Early Diagnosis of Oral Premalignant and Malignant Lesions
Authors: Singh Vasudha , Bhargava Mudita , Varma Kachnar , Misra Vatsala , Singh Richa
Published: September 2021

Introduction: Incidence of oral epithelial dysplasia and oral squamous cell carcinoma (SCC) is very high in south Asian countries as compared to western population owing to a greater use of tobacco in these regions. While visual examination and exfoliative cytology are the most common screening and diagnostic modalities at present, it is a subjective analysis. Quantitative analyses such as nuclear size, cell size, and nuclear-to-cytoplasmic ratio may provide an accurate diagnosis and improve reproducibility. The aim of the study was to evaluate the role of morphometry as a diagnostic adjunct to exfoliative cytology and to derive a significant cutoff to identify the population at risk for development of SCC among chronic tobacco users. Material and Methods: This was an outpatient-based prospective study done in a tertiary hospital over a period of 2 years. Hundred and fifty cases with a history of chronic tobacco use for a minimum period of 5 years were evaluated. Visual inspection using acetic acid was done. Oral scrapes were taken for cytological and morphometric analysis followed by incision biopsy for histopathological evaluation, wherever possible. Results: On morphometrical analysis, mean nuclear area and nuclear:cytoplasmic (N:C) ratio increased, while the cytoplasmic area decreased from smears with normal cytology to oral dysplasia to SCC. Analysis of variance and post hoc Tukey’s honest significant difference test showed a statistically significant difference among the 3 groups (p value <0.05). A cutoff value for a significant N:C ratio was calculated as ≥0.08 using Youden’s index with a sensitivity and a specificity of 88% and 94%, respectively. Conclusion: In high-risk cases, morphometry can be a useful adjunct to exfoliative cytology and visual examination for an early and accurate diagnosis and timely intervention in oral potentially malignant and malignant lesions, thereby improving the prognosis.
Clinical Implementation and Initial Experience of Neutrophil Gelatinase-Associated Lipocalin Testing for the Diagnostic and Prognostic Assessment of Acute Kidney Injury Events in Hospitalized Patients
Authors: Côté Jean-Maxime , Lyons Liam , Twomey Patrick J. , Fitzgerald Ted J. , Teh Jia Wei , Holian John , O’Riordan Aisling , Watson Alan , Clince Michelle , Malik Fahad , O’Regan John , Murray Patrick T.
Published: September 2021

Introduction: The use of novel kidney injury biomarkers has been shown to improve diagnostic assessment and prognostic prediction in various populations with acute kidney injury (AKI), but their use in a standard clinical practice have been rarely reported. Methods: We reported the clinical implementation of neutrophil gelatinase-associated lipocalin (NGAL) measurement for routine AKI diagnostic workup of patients receiving nephrology consultation in a tertiary academic centre. Specific focus was made on the diagnostic performance to discriminate functional (“pre-renal”) from intra-renal AKI and to predict AKI progression. Results: Forty-five urine NGAL (uNGAL) and 25 plasma NGAL (pNGAL) samples in the first 50 consecutive patients were analysed. KDIGO Stage 1, 2, 3 AKI, and renal replacement therapy occurred in 10%, 40%, 50%, and 24% of cases, respectively. The uNGAL was lower in patients with transient AKI (<48 h) and no sign of urinary tract infections (37 [25–167] ng/mL) than sustained or progressive AKI (298 [74–1,308] ng/mL) (p = 0.016), while pNGAL did not discriminate transient (264 [100–373] ng/mL) from persistent AKI (415 [220–816] ng/mL) (p = 0.137). The median uNGAL level was 63 (35–1,123) ng/mL for functional/pre-renal AKI and 451 (177–1,315) ng/mL for intra-renal AKI (p = 0.043), while the pNGAL was 264 (114–468) and 415 (230–816) ng/mL (p = 0.235), respectively. Conclusion: NGAL, as part of the routine workup, is useful for diagnostic and prognostic assessment of new-onset AKI in clinical practice. Interpretation of an increased NGAL level should be clinically evaluated in its clinical context, particularly considering concomitant infection (urinary or systemic). Clinical adoption of emerging AKI biomarkers as diagnostic tests in clinical practice should be further encouraged.
The Postoperative Course of Choroidal and Central Retinal Thickness in Epiretinal Membranes with Respect to Membrane Severity
Authors: Zobor Gergely , Sacu Stefan , Hollaus Marlene , Aliyeva Leyla , Schmalek Alexandra-Stephanie , Schmidt-Erfurth Ursula , Georgopoulos Michael
Published: September 2021

Introduction: The aim of this study was to evaluate the relation between choroidal thickness (CT), central retinal thickness (CRT) and best-corrected visual acuity (BCVA) after surgery for idiopathic epiretinal membrane (iERM). Methods: Patients with 4 severity stages of iERM, who underwent vitrectomy with membrane- and internal limiting membrane peeling, were included in this prospective study. CRT, CT, and BCVA were assessed at baseline (BSL), 1 week, 1 and 3 months postoperatively. Results: Twenty-one eyes were phakic, 11 eyes pseudophakic at BSL, in 14 cases combined cataract surgery was performed. BCVA was highest in stage 1 and 2, lowest in stage 4 iERM (p < 0.001) and correlated with CRT. After surgery, CRT decreased and BCVA increased significantly (p < 0.05). CT did not show significant differences among stages (p = 0.23). BSL CRT did not differ between phakic and pseudophakic eyes, the least reduction after surgery was detected in patients who underwent combined cataract surgery and vitrectomy. BSL CT was greater in phakic than in pseudophakic eyes (p = 0.033). Postoperative CT decreased in pseudophakic and phakic eyes, but remained higher after combined surgery (p = 0.0048). Conclusion: CT is not related to the severity of iERM. Choroidal changes did not influence the BCVA. Additional cataract surgery seems to cause longer recovery in CT and CRT.
Nonsyndromic Early-Onset Epileptic Encephalopathies: Two Novel KCTD7 Pathogenic Variants and a Literature Review
Authors: Binaafar Sima , Garshasbi Masoud , Tavasoli Ali Reza , Badv Reza Shervin , Hosseiny Seyyed Mohammad Mahdi , Samanta Debopam , Rabbani Bahareh , Mahdieh Nejat
Published: September 2021

Early-onset epileptic encephalopathies (EOEE) affect cognitive, sensory, and motor development. Genetic variations are among the identifiable primary causes of these syndromes. However, some patients have been reported to be affected by EOEE without any other clinical symptoms and signs. We study the genotype and phenotype of patients with nonsyndromic early-onset epileptic encephalopathy (NSEOEE) and report 2 novel patients from Iran. A comprehensive search was conducted in PubMed, John Willy, Springer, Elsevier, and Google Scholar databases to collect related information of all the previously reported cases with KCTD7 mutations. Fifty-four patients (from 40 families) were investigated. Using trio-whole-exome sequencing (trio-WES) and Sanger sequencing, the possible genetic causes of the disorder were checked. The probable impacts of the identified variants on the KCTD7 protein structure and function were predicted. This study provided a detailed overview of all published KCTD7 mutations and 2 de novo ones. We identified 2 novel homozygous variants of uncertain significance, c.458 G > A p. Arg153His and c.529C > T (p.Arg177Cys), in KCTD7 (NM_153033.4) (Chr7(GRCh37)). There is a significant wide distribution of the KCTD7 gene causing NSEOEE among different populations. In conclusion, KCTD7 mutations demonstrate a diverse geographical distribution alongside a wide range of ethnicities. This highlights the importance of careful consideration in the WES data analysis. Mutations of this gene may be a common cause of NSEOEE. Also, this study imprints targeted therapeutic opportunities for potassium channelepsies such as KCTD7-related NSEOEE.
Cardioneuroablation for Treatment of Atrioventricular Block
Authors: Aksu Tolga , Gopinathannair Rakesh , Bozyel Serdar , Yalin Kivanc , Gupta Dhiraj
Published: September 2021

Background:

The contribution of autonomic influences to atrioventricular block (AVB) is unclear. Although cardioneuroablation has been used to treat cardioinhibitory vasovagal syncope, its role in treating functional paroxysmal and persistent AVB has not been formally evaluated.

Methods:

We used a stepwise protocol in 241 consecutive patients presenting with symptomatic AVB to identify 31 (12.9%) patients with functional or vagally mediated AVB. All patients had episode(s) of syncope in previous 12 months, and AVB was persistent in 17 (54.8%) patients. All 31 patients received targeted catheter-based cardioneuroablation, and their follow-up outcomes were evaluated with serial Holter monitoring.

Results:

Twenty-eight patients received biatrial or left-sided cardioneuroablation while 3 received only right-sided cardioneuroablation because of structural factors that precluded safe attempts at transseptal puncture. Procedural success, as defined as acute reversal of AVB and complete abolition of atropine response, was achieved in 30 (96.7%) cases, while the remaining patient received a pacemaker. Over a mean follow-up of 19.3±15 months, AVB episodes were observed in 2 (6.7%) of 30 cases, and 3 (9.6%) patients required pacemaker implantation during follow-up.

Conclusions:

Functional AVB can be identified in a minority of patients presenting with high-grade AVB. Cardioneuroablation for these patients results in encouraging medium-term outcomes.
Was Henry VIII Infertile? Miscarriages and Male Infertility in Tudor England
Authors: Shrimplin Valerie , Jayasena Channa N.
Published: September 2021

Although fertility has traditionally been viewed as the responsibility of women, recent studies suggest that reduced sperm function is a major cause of the recurrent pregnancy loss that affects 1 to 2 percent of couples. The reproductive and nutritional history of King Henry VIII indicates that 70 percent of the legitimate pregnancies attributed to Henry and his six wives resulted in miscarriage or stillbirth. By comparison, only 10 percent of the recorded pregnancies of the thirty-one noblemen closely associated with Henry had the same outcomes. Henry’s reproductive health likely contributed to the fertility problems for which his wives took the blame. The disregard of male infertility in Henry’s case may offer a clue to the reasons for the under-reporting of male reproductive health, then and now, to the detriment of both men and women.
Intersections of gender and age in accessing River Basin Resources in Tanzania: a comparative analysis of fishing and agro-pastoralist communities in rural areas of Tanzania
Authors: Shitima Christina M.
Published: September 2021

This paper applies intersectionality theories to investigate how informal social relations factors in terms of age and gender interact to affect people’s access to river basin resources (RBR) in Tanzania. Access to RBR is defined as practical rights to use RBR and benefits that are accrued from the use of RBR. Data were collected from a survey conducted among households living along the Kilombero River in Tanzania. Three villages that differ in cultural backgrounds i.e. a fishing community, an agro-pastoralist community and a village with people from multi-cultural groups were included in the survey. A multivariate probit model is used to determine access in terms of practical rights to use RBR, and a generalized ordered logit model is used to determine access in terms of benefits from the use of RBR. Findings show that both practical rights to use RBR and benefits from the use of resources are highly gendered, though their impact differs according to age groups and cultural groups. One common feature in all cultural groups is that the norms that deny women rights to use RBR result in a gendered distribution of labour, especially when access to RBR leads to income-generating activities. The findings also highlight that women are less likely to benefit from the use of resources. Within a single cultural group, a fishing community, the study found that benefits from the use of RBR vary according to age. In line with intersectionality theories, we conclude that, both men and women are heterogeneous groups in societies. While it is generally perceived that women in rural areas are the victims of norms that deny their development, this is not the case for all women. Findings also reveal the importance of distinguishing between practical rights to use resources and benefits derived from their use.
Influence of institutions on value creation activities of micro and small enterprises in rural Tanzania
Authors: Msamula Jasinta , Vanhaverbeke Wim , Tutuba Nicholaus B.
Published: September 2021

Economic development initiatives in Tanzania recognise the importance of enterprises in the country’s economy. Similarly, rural entrepreneurship has the potential to stimulate the rural economy. The promotion of rural entrepreneurship can help to fulfil that potential, with creation of value for customers as one of the promotion initiatives. Institutions govern the value creation activities of enterprises. By focusing on the wood furniture industry, this research article analyses the influence of institutions on the value creation activities of rural Micro and Small Enterprises (MSEs) in Tanzania. The institution theory and the value chain model are its theoretical bases. The Mvomero district is the study area. Interviews and discussions are the data collection methods used in this qualitative study and 14 cases are analysed. The study finds that four institutional concerns influence the value creation activities of enterprises and these are: regulations compliance; regulations enforcement; regulations knowledge; and regulatory costs. However, the study excludes informal institutions. Its findings may be beneficial to stakeholders such as policymakers, development stakeholders, researchers – as well as rural MSEs.
Review of the Chinese species of Deleaster Erichson, 1839 (Coleoptera, Staphylinidae, Oxytelinae) with a mitogenome of Deleaster bactrianus Semenov, 1900
Authors: WANG LIN-FEI , LÜ LIANG
Published: September 2021

Deleaster Erichson is an oxyteline genus with only 12 species worldwide, but its members have very distinctive appearance and bear primitive characters, which are particularly critical in understanding the evolution of Oxytelinae. Here we review the species in China and provide a new record species, Deleaster bactrianus Semenov, to Chinese fauna of this genus. Additionally, we describe the first complete mitochondrial genome of Deleaster.
Holotypes for three Caspian gastropods of the family Hydrobiidae tracked down: description and taxonomic interpretations
Authors: ANISTRATENKO VITALIY V. , SITNIKOVA TATIANA YA. , ANISTRATENKO OLGA YU.
Published: September 2021

Type series of three nominal taxa of the hydrobiid gastropods inhabiting the Caspian Sea were traced recently in the uncatalogued part of the malacological collection of the Zoological Institute of Russian Academy of Sciences, Saint-Petersburg. Images of the holotypes and some paratypes of Pyrgula isseli Logvinenko & Starobogatov, 1969, P. sowinskyi Logvinenko & Starobogatov, 1969 and P. derzhavini Logvinenko & Starobogatov, 1969 are presented. The first two species belong to the genus Clathrocaspia (subfamily Caspiinae) and P. sowinskyi is considered a junior synonym of C. pallasii (Clessin & W. Dybowski in W. Dybowski, 1887). The attribution of the third species, P. derzhavini, to Laevicaspia (Pyrgulinae) is confirmed based on the newly discovered type material. Based on the additional information we update ecological data and distribution ranges of the species, provide comments on their nomenclature, systematic position and taxonomic rank.
One new genus and six new species (Orthoptera: Tettigoniidae: Meconematini) from Yunnan, China
Authors: SHI FUMING , ZHANG LIDAN
Published: September 2021

The paper reported one new genus and six new species from Yunnan, China. The new genus, Neoteratura gen. nov. is similar to the genus Alloteratura Hebard, 1922, but differs from the latter by: apical segment of maxillary palpus slightly shorter than subapical one; humeral sinus indistinct; tegmina shorter, not reaching or slightly surpassing apex of abdomen, but longer than hind wings; male genitalia sclerotized, simple; cercus divided into two branches, or with branches. It resembles the genus Borneratura Gorochov, 2008, but differs from the latter by: tegmina and hind wings shorter; male genitalia sclerotized, cercus with branches.
When Running for Office Runs in the Family: Horizontal Dynasties, Policy, and Development in the Philippines
Authors: Dulay Dean , Go Laurence
Published: September 2021

Political dynasties exist in practically every type of democracy, but take different forms in different places. Yet the types of dynastic structures have remained unexplored. We argue that horizontal dynasties—multiple members from the same political family holding different political offices concurrently—affect policymaking by replacing potential political rivals, who may oppose an incumbent’s policy choices, with a member of the family. But in developing countries, the policy change that accrues from dynastic status may not lead to higher levels of economic development. We test this argument’s implications in the Philippines. Using a close elections regression discontinuity design on a sample of mayors, we show that (i) horizontally dynastic mayors have higher levels of government spending, (ii) direct institutional constraints are the mechanism that drives this core result, and (iii) horizontally dynastic mayors do not lead to higher economic growth economic growth or lower poverty.
How Moral Expectancy Violations Influence Audiences’ Affective Dispositions Toward Characters
Authors: Matthews Nicholas L. , Bonus James Alex
Published: September 2021

Affective disposition theory (ADT) explains that the moral judgments of character behavior inform dispositions toward characters. These dispositions bias moral judgments of characters’ subsequent behaviors and establish behavioral expectations. We used expectancy violations theory to help specify people’s dispositions toward characters. In study 1, we modified the footbridge dilemma to develop experimental stimuli and predictions. Studies 2 and 3 observed the disposition formation process longitudinally and validated our stimulus: a custom-built visual novel. Study 4 tested our predictions. Studies 2 through 4 used pre-registered hypotheses, sampling, and data analyses. Results demonstrated that the current disposition (positive vs. negative) changes how a novel (im)moral behavior affects that disposition. Schema-violating behaviors provoked larger mean differences in participants’ dispositions toward protagonists compared to antagonists. Specifically, people were hyper-scrutinous of moral paragons and entrenched despised characters in moral skepticism. Additionally, we observed differences in dispositions toward characters who did not act when they could (inaction).
Amyloid-β disrupts unitary calcium entry through endothelial NMDA receptors in mouse cerebral arteries
Authors: Peters Emily C , Gee Michael T , Pawlowski Lukas N , Kath Allison M , Polk Felipe D , Vance Christopher J , Sacoman Juliana L , Pires Paulo W
Published: September 2021

Transient increases in intracellular Ca2+ activate endothelium-dependent vasodilatory pathways. This process is impaired in cerebral amyloid angiopathy, where amyloid- β(1-40) accumulates around blood vessels. In neurons, amyloid- β impairs the Ca2+-permeable N-methyl-D-aspartate receptor (NMDAR), a mediator of endothelium-dependent dilation in arteries. We hypothesized that amyloid- β(1-40) reduces NMDAR-elicited Ca2+ signals in mouse cerebral artery endothelial cells, blunting dilation. Cerebral arteries isolated from 4-5 months-old, male and female cdh5:Gcamp8 mice were used for imaging of unitary Ca2+ influx through NMDAR ( NMDAR sparklets) and intracellular Ca2+ transients. The NMDAR agonist NMDA (10 µmol/L) increased frequency of NMDAR sparklets and intracellular Ca2+ transients in endothelial cells; these effects were prevented by NMDAR antagonists D-AP5 and MK-801. Next, we tested if amyloid- β(1-40) impairs NMDAR-elicited Ca2+ transients. Cerebral arteries incubated with amyloid- β(1-40) (5 µmol/L) exhibited reduced NMDAR sparklets and intracellular Ca2+ transients. Lastly, we observed that NMDA-induced dilation of pial arteries is reduced by acute intraluminal amyloid- β(1-40), as well as in a mouse model of Alzheimer’s disease, the 5x-FAD, linked to downregulation of Grin1 mRNA compared to wild-type littermates. These data suggest that endothelial NMDAR mediate dilation via Ca2+-dependent pathways, a process disrupted by amyloid- β(1-40) and impaired in 5x-FAD mice.
Winning the Australasian Reporting Awards: An analysis of accounting and economic outcomes
Authors: Adrian Christofer , Choi Ka Wai (Stanley) , Garg Mukesh , Truong Cameron
Published: September 2021

Despite the intuition that winning reporting awards should be primarily based on reporting quality, we find no evidence that Australian Securities Exchange (ASX)-listed firms winning the Australasian Reporting Awards (ARA) over the period 2003–2016 exhibit higher financial reporting quality. However, we find that winning reporting awards is associated with higher annual report readability. Next, firms winning the ARA neither show superior future accounting performance nor higher market valuation. We also find that investors are not compensated with higher stock returns. Taken together, our findings suggest that the criteria applied to decide the ARA winners capture higher levels of readability but do not correlate with common academic signals of financial reporting quality. Users of the ARA outcomes should also be cautious with the immediate interpretation that the ARA are reliable signals of superior corporate performance.

JEL Classification: D82, L15, M41
Childhood Sexual Abuse and Exposure to Peer Bullying Victimization
Authors: Kennedy Reeve S. , Font Sarah A. , Haag Ann-Christin , Noll Jennie G.
Published: September 2021

Females exposed to child sexual abuse (CSA) are at an increased risk of experiencing further victimization in adolescence. Associations between CSA and several forms of cyber and in-person peer bullying victimization were assessed in a prospective, longitudinal study. Females exposed to substantiated CSA and a matched comparison group (N = 422) were followed over a two-year period. Bullying experiences were assessed in both survey and qualitative interviews. Qualitative data were coded and used to describe the types (e.g., cyber, physical, verbal), and foci (e.g., threats, physical appearance) of bullying victimization. Logistic regression was used to assess the odds that CSA was associated with subsequent bullying victimization, adjusted for demographics, social networking use, and prior bullying. CSA-exposed females were at an increased risk of multiple forms of bullying victimization with a persistent risk of bullying victimization over time. Specifically, they had 2.6 times higher odds of experiencing any bullying at follow-up, 2.9 times higher odds of experiencing cyberbullying at follow-up, and 2 times higher odds of experiencing combined cyber/in-person bullying at follow-up. CSA-exposed females were more likely than comparison females to experience bullying regarding their appearance/weight and dating relationships. Findings provide further insight into the unique circumstances of the cyberbullying and in-person bullying experienced by CSA-exposed females. Females exposed to child sexual abuse (CSA) are at an increased risk of experiencing bullying victimization, specifically cyberbullying and combined cyber/in-person bullying, as well as bullying about their appearance and dating relationships. These findings indicate that bullying prevention needs to include trauma-focused components to target these uniquely vulnerable females.