bluuebunny/crossref_metadata_2025 huggingface dataset:
PRODUÇÃO CIENTÍFICA DO ENCONTRO DE ESTUDOS ORGANIZACIONAIS SOB A ÓPTICA DA ANÁLISE DE REDES SOCIAIS
Authors: Ribeiro Henrique César Melo
Published: January 2022

O objetivo deste estudo foi investigar o perfil e as características da produção científica dos artigos divulgados nas 10 Edições do EnEO sob a óptica da análise de redes sociais. Metodologicamente, foi uma pesquisa com abordagem quantitativa, utilizando-se de pesquisa documental e análises de redes sociais. Foram mensurados e investigados os seguintes indicadores de redes sociais: (a) redes de coautoria por Edição do EnEO acumulada; (b) redes de coautoria das 10 Edições do EnEO; (c) rede social das IES; (d) rede social dos estados e cidades internacionais; (e) rede social das regiões do Brasil; e (f) rede social dos países. Os principais resultados apontam uma baixa densidade em todas as redes sociais investigadas, contudo, com é perceptível que as redes de coautoria estudadas estão em fase de evolução, influenciando de maneira inerente as outras redes de colaboração, contribuindo com isso para o aperfeiçoamento, desenvolvimento e crescimento da produção científica investigada no panorama científico nacional.
High-performance hybrid time/frequency-domain topology optimization for large-scale photonics inverse design
Authors: Hammond Alec M. , Oskooi Ardavan , Chen Mo , Lin Zin , Johnson Steven G. , Ralph Stephen E.
Published: January 2022

We present a photonics topology optimization (TO) package capable of addressing a wide range of practical photonics design problems, incorporating robustness and manufacturing constraints, which can scale to large devices and massive parallelism. We employ a hybrid algorithm that builds on a mature time-domain (FDTD) package Meep to simultaneously solve multiple frequency-domain TO problems over a broad bandwidth. This time/frequency-domain approach is enhanced by new filter-design sources for the gradient calculation and new material-interpolation methods for optimizing dispersive media, as well as by multiple forms of computational parallelism. The package is available as free/open-source software with extensive tutorials and multi-platform support.
Asymmetrical interface design for unidirectional light extraction from spectrum conversion films
Authors: Shen Lihua , Lou Runnan , Yin Xiaobo
Published: January 2022

In this study, we propose a micro-sized photonic structure that extracts 89% of the intrinsic trapped photons from the spectrum conversion film into free space using the Monte-Carlo ray-tracing method. Furthermore, the spectrum of the spectral-shifting film can be accurately simulated based on a mean free path concept, providing the estimation of its overall performance including the external quantum efficiency and the self-absorption efficiency. The simulations show that the spectrum conversion film with micro-structures shows a two-fold increase in the total external quantum efficiency and a four-fold increase in the external quantum efficiency in the forward viewing direction compared to the planar spectrum conversion films without micro-structures.
Computer-automated design of mode-locked fiber lasers
Authors: Feehan James S. , Yoffe Samuel R. , Brunetti Enrico , Ryser Manuel , Jaroszynski Dino A.
Published: January 2022

We automate the mode-locked fiber laser design process using a modified genetic algorithm and an intuitive optimization loss function to control highly accurate polarization-resolved simulations of laser start-up dynamics without user interaction. We reconstruct both the cavity designs and output pulse characteristics of experimentally demonstrated Yb-fiber all-normal dispersion, dispersion-managed, and wavelength-tuneable all-anomalous dispersion Tm-fiber femtosecond lasers with exceptional accuracy using minimal prior knowledge, and show that our method can be used to predict new cavity designs and novel mode locking states that meet target pulse requirements. Our approach is directly applicable to a broad range of mode locking regimes, wavelengths, pulse energies, and repetition rates, requires no training or knowledge of the loss function gradients, and is scalable for use on supercomputers and inexpensive desktop computers.
Control of spectral shift, broadening, and pulse compression during mid-IR self-guiding in high-pressure gases and their mixtures
Authors: Migal Ekaterina , Pushkin Andrey , Minaev Nikita , Bravy Boris , Potemkin Fedor
Published: January 2022

Precise control of the nonlinear optical phenomena is the limiting factor for the spectral broadening and pulse compression techniques for high-power laser systems. Here we demonstrate that generation of the blue and red components under filamentation of 4.55-μm mid-IR pulses can be easily adjusted independently through the use of inert and molecular gases, while uniform broadening up to 1-μm bandwidth at the 1/e2 level relies on the proper choice of gas mixture and its compounds partial pressure. Such synthesized media provide a feasible route for the free of damage control of pulse spectral broadening and compression for gigawatt peak power laser systems operating in the mid-IR. Additional management of a generated spectrum can be realized through the adjustment of focusing conditions. The resulted pulse is compressed by a factor of 2.6 down to 62 fs pulse duration (4.1 optical cycles) with additional dispersion compensation. Controllable nonlinear compression down to four optical cycles keeping the millijoule energy level of a mid-IR laser pulse provides direct access to extreme nonlinear optics.
Identifying risk factors and implications for beach drowning prevention amongst an Australian multicultural community
Authors: Woods Mark , Koon William , Brander Robert W.
Published: January 2022

Multicultural communities in Australia are recognised as a priority area for drowning prevention, but no evidence-based study has addressed their knowledge of beach safety. This study used an online survey tool to identify and examine risk factors relating to swimming ability, beach visitation characteristics and behaviour, and beach safety knowledge of the Australian Southern Asian community to assist in the development of future beach safety interventions. Data was obtained through 249 online and in-person surveys of people aged > 18 years. Most respondents reported poor swimming ability (80%), often swam in in the absence of lifeguards (77%), did not understand the rip current hazard (58%), but reported that they entered the water (76%) when visiting beaches. Close to one-quarter (28%) had not heard, or didn’t know the purpose, of the red and yellow beach flags, which identify lifeguard supervised areas on Australian beaches. Length of time living in Australia is an important beach safety consideration for this community, with minimal differences in terms of gender and age. Those who have lived < 10 years in Australia visit beaches more frequently and are less likely to have participated in swimming lessons, be able to swim, heard of the flags or swim between them, understand rip currents, or have participated in a beach safety program. Very few (3%) respondents received beach safety information from within their own community. The importance of beach safety education and swimming lessons within the Southern Asian community should be prioritised for new and recent migrants to Australia.
Evaluation of the discriminatory power of spoligotyping and 19-locus mycobacterial interspersed repetitive unit-variable number of tandem repeat analysis (MIRU-VNTR) of Mycobacterium bovis strains isolated from cattle in Algeria
Authors: Belakehal Faïza , Barth Stefanie A. , Menge Christian , Mossadak Hamdi T. , Malek Naïm , Moser Irmgard
Published: January 2022

Bovine tuberculosis (bTB) caused by Mycobacterium (M.) bovis and M. caprae is a transmissible disease of livestock, notifiable to the World Organization for Animal Health (OIE). BTB particularly affects cattle and small ruminants and can be transmitted to humans thereby posing a significant threat to veterinary and public health worldwide. M. bovis is the principal cause of bTB in Algeria. In order to better understand the route of spreading and elaborate an eradication program, isolation and characterization of mycobacteria from Algerian cattle was performed. Sixty strains belonging to the M. tuberculosis complex were analyzed by spoligotyping, thereof 42 by 19-locus-MIRU-VNTR-typing. Spoligotyping revealed 16 distinguishable patterns (Hunter-Gaston discriminatory index [HGDI] of 0.8294), with types SB0120 (n = 20) and SB0121 (n = 13) being the most frequent patterns, representing 55% of the strains. Analyses based on 19-locus-MIRU-VNTR yielded 32 different profiles, five clusters and one orphan pattern, showing higher discriminatory power (HGDI = 0.9779) than spoligotyping. Seven VNTR-loci [VNTR 577 (alias ETR C), 2163b (QU11b), 2165 (ETR A), 2461 (ETR B), 3007 (MIRU 27), 2163a (QUB11a) and 3232 (QUB 3232)] were the most discriminative loci (HGDI ˃ 0.50). In conclusion, 19-locus-MIRU-VNTR yielded more information than spoligotyping concerning molecular differentiation of strains and better supports the elucidation of transmission routes of M. bovis between Algerian cattle herds.
Analysis of the spatio-temporal network of air pollution in the Yangtze River Delta urban agglomeration, China
Authors: Yang Chuanming , Zhuo Qingqing , Chen Junyu , Fang Zhou , Xu Yisong
Published: January 2022

The complex correlation between regions caused by the externality of air pollution increases the difficulty of its governance. Therefore, analysis of the spatio-temporal network of air pollution (STN-AP) holds great significance for the cross-regional coordinated governance of air pollution. Although the spatio-temporal distribution of air pollution has been analyzed, the structural characteristics of the STN-AP still need to be clarified. The STN-AP in the Yangtze River Delta urban agglomeration (YRDUA) is constructed based on the improved gravity model and is visualized by UCINET with data from 2012 to 2019. Then, its overall-individual-clustering characteristics are analyzed through social network analysis (SNA) method. The results show that the STN-AP in the YRDUA was overall stable, and the correlation level gradually improved. The centrality of every individual city is different in the STN-AP, which reveals the different state of their interactive mechanism. The STN-AP could be subdivided into the receptive block, overflow block, bidirectional block and intermediary block. Shanghai, Suzhou, Hangzhou and Wuxi could be key cities with an all above degree centrality, betweenness centrality and closeness centrality and located in the overflow block of the STN-AP. This showed that these cities had a greater impact on the STN-AP and caused a more pronounced air pollution spillovers. The influencing factors of the spatial correlation of air pollution are further determined through the quadratic assignment procedure (QAP) method. Among all factors, geographical proximity has the strongest impact and deserves to be paid attention in order to prevent the cross-regional overflow of air pollution. Furthermore, several suggestions are proposed to promote coordinated governance of air pollution in the YRDUA.
A systematic review and meta-analysis uncovering the relationship between alcohol consumption and sickness absence. When type of design, data, and sickness absence make a difference
Authors: S. Hashemi Neda , Skogen Jens Christoffer , Sevic Aleksandra , Thørrisen Mikkel Magnus , Rimstad Silje Lill , Sagvaag Hildegunn , Riper Heleen , Aas Randi Wågø
Published: January 2022

Aim

Earlier research has revealed a strong relationship between alcohol use and sickness absence. The aim of this review was to explore and uncover this relationship by looking at differences in type of design (cross-sectional vs. longitudinal), type of data (self-reported vs. registered data), and type of sickness absence (long-term vs. short term).

Method

Six databases were searched through June 2020. Observational and experimental studies from 1980 to 2020, in English or Scandinavian languages reporting the results of the association between alcohol consumption and sickness absence among working population were included. Quality assessment, and statistical analysis focusing on differences in the likelihood of sickness absence on subgroup levels were performed on each association, not on each study. Differences in the likelihood of sickness absence were analyzed by means of meta-analysis. PROSPERO registration number: CRD42018112078.

Results

Fifty-nine studies (58% longitudinal) including 439,209 employees (min. 43, max. 77,746) from 15 countries were included. Most associations indicating positive and statistically significant results were based on longitudinal data (70%) and confirmed the strong/causal relationship between alcohol use and sickness absence. The meta-analysis included eight studies (ten samples). The increased risk for sickness absence was likely to be found in cross-sectional studies (OR: 8.28, 95% CI: 6.33–10.81), studies using self-reported absence data (OR: 5.16, 95% CI: 3.16–8.45), and those reporting short-term sickness absence (OR: 4.84, 95% CI: 2.73–8.60).

Conclusion

This review supports, but also challenges earlier evidence on the association between alcohol use and sickness absence. Certain types of design, data, and types of sickness absence may produce large effects. Hence, to investigate the actual association between alcohol and sickness absence, research should produce and review longitudinal designed studies using registry data and do subgroup analyses that cover and explain variability of this association.
Pronominal anaphora resolution in Polish: Investigating online sentence interpretation using eye-tracking
Authors: Wolna Agata , Durlik Joanna , Wodniecka Zofia
Published: January 2022

The mechanism of anaphora resolution is subject to large cross-linguistic differences. The most likely reason for this is the different sensitivity of pronouns to the range of factors that determine their reference. In the current study, we explored the mechanism of anaphora resolution in Polish. First, we explored preferences in the interpretation of null and overt pronouns in ambiguous sentences. More specifically, we investigated whether Polish speakers prefer to relate overt pronouns to subject or object antecedents. Subsequently, we tested the consequences of violating this bias when tracing the online sentence-interpretation process using eye-tracking. Our results show that Polish speakers have a strong preference for interpreting null pronouns as referring to subject antecedents and interpreting overt pronouns as referring to object antecedents. However, in online sentence interpretation, only overt pronouns showed sensitivity to a violation of the speaker’s preference for a pronoun-antecedent match. This suggests that null pronoun resolution is more flexible than overt pronoun resolution. Our results indicate that it is much easier for Polish speakers to shift the reference of a null pronoun than an overt one whenever a pronoun is forced to refer to a less-preferred antecedent. These results are supported by naturalness ratings, which showed that null pronouns are considered equally natural regardless of their reference, while overt pronouns referring to subject antecedents are rated as considerably less natural than those referring to object antecedents. To explain this effect, we propose that the interpretation of null and overt pronouns is sensitive to different factors which determine their reference.
How social learning shapes the efficacy of preventative health behaviors in an outbreak
Authors: Carrignon Simon , Bentley R. Alexander , Silk Matthew , Fefferman Nina H.
Published: January 2022

The global pandemic of COVID-19 revealed the dynamic heterogeneity in how individuals respond to infection risks, government orders, and community-specific social norms. Here we demonstrate how both individual observation and social learning are likely to shape behavioral, and therefore epidemiological, dynamics over time. Efforts to delay and reduce infections can compromise their own success, especially when disease risk and social learning interact within sub-populations, as when people observe others who are (a) infected and/or (b) socially distancing to protect themselves from infection. Simulating socially-learning agents who observe effects of a contagious virus, our modelling results are consistent with with 2020 data on mask-wearing in the U.S. and also concur with general observations of cohort induced differences in reactions to public health recommendations. We show how shifting reliance on types of learning affect the course of an outbreak, and could therefore factor into policy-based interventions incorporating age-based cohort differences in response behavior.
Changes of starch and sucrose content and related gene expression during the growth and development of Lanzhou lily bulb
Authors: Li Weitai , Huang Dengjing , Wang Bo , Hou Xuemei , Zhang Rui , Yan Mei , Liao Weibiao
Published: January 2022

As the main forms of carbohydrates, starch and sucrose play a vital role in the balance and coordination of various carbohydrates. Lanzhou lily is the most popular edible lily in China, mainly distributed in the central region of Gansu. To clarify the relationship between carbohydrate metabolism and bulb development of Lanzhou lily, so as to provide a basis for the promotion of the growth and development in Lanzhou lily and its important economic value, we studied lily bulbs in the squaring stage, flowering stage, half withering stage and withering stage. The plant height, fresh weight of mother and daughter bulbs continued to increase during the whole growth period and fresh weight of stem and leaf began to decrease in the half withering stage. The content of starch, sucrose and total soluble sugar in the lily mother bulb accumulated mostly in the flowering, withering and half withering stages, respectively. Starch, sucrose and total soluble sugar accumulated in the daughter bulb with the highest concentration during the withering stage. In the transcription level, sucrose synthase (SuSy1) and sucrose invertase (INV2) expressed the highest in squaring stage, and the expression was significantly higher in the mother bulb than in the daughter bulb. In flowering stage, the expression levels of soluble starch synthase (SSS1), starch-branching enzyme (SBE) and adenosine diphosphate-glucose pyrophosphorylase (AGP1) genes were higher in the mother bulb than in the daughter bulb. Altogether, our results indicate that starch and sucrose are important for the bulb growth and development of Lanzhou lily.
Preclinical evidence for mitochondrial DNA as a potential blood biomarker for chemotherapy-induced peripheral neuropathy
Authors: Trecarichi Annalisa , Duggett Natalie A. , Granat Lucy , Lo Samantha , Malik Afshan N. , Zuliani-Álvarez Lorena , Flatters Sarah J. L.
Published: January 2022

Chemotherapy-induced peripheral neuropathy (CIPN) is a serious dose-limiting side effect of several first-line chemotherapeutic agents including paclitaxel, oxaliplatin and bortezomib, for which no predictive marker is currently available. We have previously shown that mitochondrial dysfunction is associated with the development and maintenance of CIPN. The aim of this study was to evaluate the potential use of mitochondrial DNA (mtDNA) levels and complex I enzyme activity as blood biomarkers for CIPN. Real-time qPCR was used to measure mtDNA levels in whole blood collected from chemotherapy- and vehicle-treated rats at three key time-points of pain-like behaviour: prior to pain development, at the peak of mechanical hypersensitivity and at resolution of pain-like behaviour. Systemic oxaliplatin significantly increased mtDNA levels in whole blood prior to pain development. Furthermore, paclitaxel- and bortezomib-treated animals displayed significantly higher levels of mtDNA at the peak of mechanical hypersensitivity. Mitochondrial complex I activity in whole blood was assessed with an ELISA-based Complex I Enzyme Activity Dipstick Assay. Complex I activity was not altered by any of the three chemotherapeutic agents, either prior to or during pain-like behaviour. These data demonstrate that blood levels of mtDNA are altered after systemic administration of chemotherapy. Oxaliplatin, in particular, is associated with higher mtDNA levels before animals show any pain-like behaviour, thus suggesting a potential role for circulating mtDNA levels as non-invasive predictive biomarker for CIPN.
A Critical Review of Open Innovation in SMEs: Implementation, Success Factors and Challenges
Authors: Wibisono Eristian
Published: January 2022

Abstract

This literature review explores the Open Innovation of SME companies, their application, success factors, impact, and challenges. The theoretical framework is built starting from the definition, a critical pillar, and Open Innovation in SME companies. The main factor in the Open Innovation process stage is finding innovative ideas and establishing network access with the external environment. Balanced, systematic, and thorough collaboration is the key to this process. Although European scholars have done it quite a lot, the study of literature on Open Innovation in SMEs still could continue to be developed. Several research results were found in studies conducted in developing countries such as China, Taiwan, and Korea, distinguishing them from similar studies in Europe.

Keywords: innovation; SMEs; technology; entrepreneurship; open innovation
The Reorientation of Thailand’s National R&D Programmes - Limits and Challenges
Authors: Jutarosaga Anittha , Hengjan Yupadee , Charoenpornpattana Santi , Jitvanichphaibool Kommate
Published: January 2022

Since 2016 Thailand has recognised a significant transition in research and innovation policy, with government increasingly acknowledging the importance of national R&D programmes and favourable institutional conditions as determinants to overcome middle income trap. Drawing a lesson-learned from successful experiences of South Korea and Japan, the Thai government decided to experiment the national large-scaled mission-oriented R&D programme, known as ‘Spearhead R&D Programme’. This novel innovation financing scheme was designed to accelerate the commercialisation and economic impact of R&D outputs. From the outset, it was clear that the outcome and impact of Spearhead R&D Programme was yet to be realized. The purpose of this paper is to investigate the reorientation of Thailand’s research and innovation landscape with the focus on the efficiency of operation in relation to the objective of the Spearhead R&D Programme. It is found that the Spearhead R&D Programme is equipped with four novel conceptual and operational features including strategic national STI agenda, R&D commercialization, multi-year budget allocation and proactive research management. Yet, there were also potential limits and challenges that need to be addressed to move the Programme towards greater sectoral contribution with open innovation and flexibility in policy learning.

 

Keywords: Research & Innovation Reform, Mission-oriented R&D Programme, Policy Experiment, Catch-up, R&D Commercialisation, Thailand
An Empirical Analysis of AI Related Scientific Knowledge and Technologies To Support Elderly Independent Living
Authors: Yuan Fei , Miyazaki Kumiko , Ruiz-Navas Santiago
Published: January 2022

The constant increase of an aging society unveils social and economic problems. Elderly independent living (EIL) is supported by numerous services and technologies that take care of their emotional and physical health. Previous studies have reviewed the potential of Artificial Intelligence (AI) applications to support health care, such as AI robots and intelligent senior well-being support systems. A growing number of scientists and tech companies are working on AI applications to help the elderly independent living. We propose to identify AI technological innovation opportunities when developing AI solutions to help the elderly independent living. The research consists of two steps: 1) Identifying AI solutions to help elderly independent living by implementing scientometric analysis on scientific publications related to AI technologies and the elderly. 2) The review and national-level comparison of the identified AI solutions under the proposed framework of elderly need, supporting function, underlying technologies and scientific knowledge. Based on an analysis of the literature on emerging technology in the third AI Boom, we pinpoint science mapping to grasp the situation of research and development of emerging technologies in various regions, to explore the status of technological and research cooperation, to find out the hot research topics of AI technologies in dealing with the problem of aging, to discover the direction of technological development and innovation opportunities in the future, and to combine with the actual need of EIL for exploring the innovative potential of AI technology. From our analysis we can argue that solutions to support elderly independent living require the integration of knowledge from various disciplines, services and products such as machine learning, sensors, data analysis, IoT, wearable devices, sociology and healthcare.

Keywords : Artificial Intelligence, Aging society, Elderly independent living, Scientometric, Network analysis
Synthesis and Application of Double Perovskite Bi1.97Eu0.03MoO6 as
Heterogeneous and Recyclable Nanocatalyst for Quinoline Synthesis
Authors: Dharmana Tejeswararao , Naidu B. Nagamani
Published: January 2022

An efficient and economical protocol for the synthesis of substituted quinolines from various 2-amino
aryl ketones and aliphatic ketones in presence of a catalytic quantity of double perovskite
Bi1.97Eu0.03MoO6 catalyst, water at ambient temperature to generate the respective quinolines in good
yields. The accompanied catalyst had high activity and stability and it might be utilized at least a few
times without losing its effectiveness.
Synthesis of CEG-AgNPs as a Promising MMPs/COX-2/Bcl-2
Signaling Pathway Modulator in BaP-Induced Lung Carcinoma
Authors: Emara Ahmed A. , Darwesh Ahmed M. , Mostafa Mohamed A. , Ahmed Ahmed A. , Rashad Khaled W. , Said Abdullah M. , Elsebaay Abdelrahman E. , Nasser Khaled M. , Amin Abdelrehem S. , Gamil Mohamed S. , Mohamed Foad H. , Ahmed Mohamed K. , Alshrief Diana A. , Hassan Mohammed E. , Nassar Zahraa , El-Ella Amr A. , Abdel-Maksoud Mostafa A. , Hussein Mohammed A.
Published: January 2022

Cucurbitacins are a class of highly oxidized tetracyclic triterpenoids. It’s hydrophobic properties and
poor solubility in water, polymeric micellar systems exhibited improved antitumor efficacy because
of a better solubilization and targeting after local and/or systemic administration. The aim of the
present work was to evaluate the anticancer activity of CEG-AgNPs against benzo[a]pyren
(BaP)-induced lung carcinoma. CEG-AgNPs was prepared, characterized and evaluated for its cytotoxic
activity against A549 lung carcinoma cell line. Also, the anticancer activity of CEG-AgNPs (70.25
mg/kg) against BaP-induced lung carcinoma was evaluated in vivo, using 30 adult mice for 43 days.
IC50 of CEG-AgNPs against A549 lung carcinoma cell line were approximately 94.47 μg/mL.
Administration of BaP (50 mg/kg b.w.) to mice induced lung carcinoma with a significant increase in
lung MMP-2, MMP-9, MMP-12, MDA, IL-6 and NF-κB as well as significant decreased in lung CAT,
GPx and GSH level. Also, treatment with BaP produced significant increase in lung VEGF-C, COX-2
and Bcl-2 gene expression as compared to control group. Daily oral administration of CEG-AgNPs to
mice treated with BaP showed a significant protection against-induced increase in lung MMP-2, MMP-9,
MMP-12, MDA, IL-6 and NF-κB levels. The treatment also resulted in a significant increase in lung
CAT, GPx and GSH level. In addition, the CEG-AgNPs could inhibit lung VEGF-C, COX-2 and
Bcl-2 gene expression as compared to BaP treated mice. The histological and MRI examination showed
that a significant normalization has been observed through in CEG-AgNPs treated mice. The
biochemical, histological and MRI results showed that CEG-AgNPs have potent anticancer activity
against BaP-induced lung carcinoma through modulating multiple cellular behaviours and signaling
pathways leading to the suppression of adaptive immune responses.
Theoretical Investigations of State Specific Hydrogen Atom
Transfer in 8-Formyl-7-hydroxy-4-methylcoumarin
Authors: Jagadeesha K. , Ramu Y.L. , Shivalingaswamy T. , Ramegowda M.
Published: January 2022

Excited state intramolecular hydrogen transfer (ESIHT) reaction of 8-formyl-7-hydroxy-4-methyl
coumarin (FC) in its pure and hydrated state FC-(H2O)4 (FCH) has been studied by implementing
state specific time dependent density functional theory (SS-TDDFT) along with the effective fragment
potential (EFP1) method for solvation with discrete water molecules. The intramolecular hydrogen
bond formed between hydroxyl hydrogen (H18) and formyl oxygen (O15) and intermolecular hydrogen
bonds formed due to microsolvation were explored. The studies of electrostatic potential, natural
charge analysis, difference electron density map and UV-Vis spectra of both FC and FCH molecules
establish the intramolecular charge transfer (ICT) states of the molecules. The vertical excitation from
S0 to S1 state causes the transfer of hydroxyl hydrogen to formyl oxygen and from S1 to S3 causes the
transfer of the hydrogen atom back to hydroxyl oxygen. Potential energy surface scans along
intramolecular hydrogen bonding at the ground and excited states confirm the state specific ESIHT
reaction in both FC and FCH molecules.
Identification and Quantification of Bisphenols in Water by Dissipation followed by
Silylation using Gas Chromatography-Mass Spectrometry Analysis
Authors: Raju Katari B.V. Narasimha , Madhu Vemula , Nowduri Annapurna , Kaliyaperumal Muralidharan , Rumalla Chidananda Swamy
Published: January 2022

Bisphenols are important endocrine disruptors, which were widely used in the variety of food packing
and storage materials which often come into contact with various food products packed in them. The
presence of bisphenols in water is harmful for the health of humans as well as aquatic animals and
also, they accumulate over a period of time. Hence, the present work aimed to develop a simple and
accurate GCMS-SIM method for the quantification of bisphenols in packaged drinking water as well
as the water samples collected in river and lakes in Andhra Pradesh state of India. Bisphenols were
extracted by simple solvent extraction with acetonitrile and silylated by N,O-bis (trimethylsilyl)trifluoro
acetamide and analyzed by GC-MS. Various parameters that affect the recovery of the analytes were
carefully optimized and the developed method was validated. The recoveries of the analytes were in
the range of 80-120 % with quantification limit of 1 ng/L. The calibration curve was linear in the
concentration range of 5 ng/L to 10 μg/L. The method was applied for the quantification of bisphenols
in packaged drinking water at room temperature and at 50 ºC at various time intervals. The results
proved that the water sample kept at room temperature doesn’t shows peaks corresponding to bisphenols.
The water sample exposed to 50 ºC for 30 days bisphenols content 10, 12, 22 and 8 ng/L respectively
for bisphenol G (BPG), bisphenol F (BPF), bisphenol E, (BPE) and bisphenol A (BPA) whereas the
same sample at 180 days of exposer shows 60, 51, 61 and 22 ng/L respectively confirms that the
leaching of plastic due to temperature increases the bisphenols level. Among the real time samples
studied, the bisphenols level was observed to be very high in Kolleru Lake and it is having 17, 14, 8
and 12 ng/L of BPG, BPF, BPE and BPA, respectively confirms that due to high plastic pollution the
bisphenols level was high in these samples. Hence, it can be concluded that the method can be suitable
for the analysis of bisphenols in drinking water as well as in wastewater samples.
Synthesis, Molecular Docking and DFT Studies of Biologically Active
N-((3-(4-Nitrophenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)aniline Derivatives
Authors: Sandhya P.V. , Kumar K.V. Satheesh , Haridas K.R.
Published: January 2022

Some biologically active pyrazole clubbed imino molecules have been designed and synthesized from
1-phenyl-3-nitro phenyl-1H- pyrazol-4-carboxaldehyde and substituted aromatic amines via acid
catalyzed condensation reaction. All the synthesized molecules were characterized by IR, 1H NMR,
13C NMR and mass spectral techniques. The in vitro antibactericidal property of the synthesized
compounds was screened and compared with the results of theoretical molecular docking. Optimization
of molecular geometry, DNA binding interaction and FMO analysis were also investigated by
computational studies using Gaussian 16 package at B3LYP/6-31G(d,p) level. All the synthesized
compounds exhibited moderate to good biological activities both experimentally and theoretically.
Effect of NaBr on the Structural, Thermal and Mechanical
Properties of HPMC:NaBr Composite Films
Authors: Kumar Sunil , Raghu S. , Demappa T. , Sannappa J.
Published: January 2022

The hydroxypropyl methylcellulose (HPMC):sodium bromide (NaBr) composite films were prepared
using different concentrations by solution casting method. The crystalline percentage of the pure
HPMC was reduced from 74% to 60% upon the incorporation of 0.7 wt.% of NaBr salt, which suggests
that the NaBr salt disrupted the host polymer crystalline phase. The two-phase microstructure in the
morphological images reflects the phase separation at different concentrations of dopant. The functional
studies revealed the considerable variation of intensity and the shift of peaks due to the action of NaBr
in the host polymer matrix. The HPMC showed a large increase in the glass transition temperature
(Tg) from 65 ºC to 86 ºC and simultaneously reduction in the weight percent loss was observed. The
mechanical analysis revealed that the added dopant has a significant effect on the mechanical properties
of HPMC.
Photocatalytic Efficiency of Hybrid Titanium Dioxide Nanowires/Reduced Graphene Oxide (TiO2NWs/RGO) for Degradation of Methyl Orange Dye
Authors: Azam B.H. , Md Fauzi M.A.F. , Razali M.H.
Published: January 2022

The aim of this research is to improve the photocatalytic efficiency by implementation of titanium dioxide nanowires/reduced graphene oxide (TiO2NWs/RGO) hybrid photocatalyst for dye degradation. The hybrid photocatalyst TiO2NWs/RGO was prepared using fabrication method. The physico-chemical properties of the photocatalyst was investigated by FTIR, XRD, SEM TGA, BET and their photocatalytic efficiency was evaluated for methyl orange degradation. Almost 100% of methyl orange was degraded by TiO2NWs/RGO hybrid photocatalyst under UV light within 210 min using 1.0 g at initial concentration of methyl orange were 10 and 20 ppm. This is due to the 1D/2D heterostructures of TiO2NWs/RGO hybrid photocatalyst that leads to the larger surface area, unique morphological and crystallinity properties, as well as excellent mobility of charge carriers and thermally stable structure
Plant Based Biosynthesis of Copper Nanoparticles and its Efficacy on
Seed Viability and Seedling Growth in Peanut (Arachis hypogaea Linn.)
Authors: Tulasi S. Lakshmi , Swamy A.V.V.S. , Peddi Pavani , Rani N. Usha
Published: January 2022

Nano-fertilizers can easily adsorb into the plant and can increase the reactive points in the plant and
hence are treated as an efficient alternative to the conventional fertilizers. Based on this, the present
study was intended to synthesize copper nanoparticles (CuNPs) using aqueous root extract of Schrebera
swietenioides Roxb. as green reducing agent. The synthesized nanoparticles were studied for its
effectiveness on enhancement of seed germination and plant growth promotion on peanut (Arachis
hypogaea Linn.). The formation of nanoparticles was confirmed by observing colour change in the
reaction mixture, which shows characteristic absorption maxima at 340 nm. The SEM and TEM analysis
confirmed that the nanoparticles were in monodispersed with spherical to irregular shape with an
average particle size of 35 nm. The EDX analysis confirmed that the nanoparticles contain 82.5%
copper metal. The synthesized nanoparticles were applied for its seed germination enhancement activity
on peanut seeds and results confirms that the nanoparticles were significantly enhances the germination
of peanut seeds with decrease in mean germination time. The peanut plant growth also enhances when
compared with metal solution treatment and untreated plants. The root length of CuNPs treated plants
was observed to be 9.27 ± 0.15 cm, which is significantly more than the untreated (6.40 ± 0.10 cm) as
well as treated copper metal (7.13 ± 0.25 cm) plants. The shoot length of 19.13 ± 0.20 cm was observed
for nano-treated plants and is greatly enhanced than the untreated (10.30 ± 0.20 cm) and treated
copper metal (11.27 ± 0.25 cm) plants. The protease activity on day 5 of the germination study was
found to be 0.904 ± 0.004, 0.133 ± 0.002 and 0.095 ± 0.002 units/mL, respectively for the peanut
seeds treated with CuNPs, copper metal solution and untreated conditions. The catalase activity at 5th
day of seed germination studies the activity was observed to be 45.177 ± 0.192, 23.691 ± 0.074 and
18.331 ± 0.209 units/min/g, respectively for CuNPs treated, copper sulphate treated and untreated pea
nut seeds. The water update of the nano treated seeds was observed to be very high along with high
quantity of photosynthetic pigments when compared with the other treatments in the study. Based on the
results achieved, it can be confirmed that the nano-treatment enhances the seed germination and plant
growth promotion on peanut seeds.
Facile Green Synthesis and Characterization of Titanium Dioxide Nanoparticles Using Kigelia
africana (Lam) Benth., Aqueous Leaf Extract and its Antioxidant and Antibacterial Activity
Authors: Rani N. Usha , Pavani P. , Prasad Rao P.T.S.R.K.
Published: January 2022

Titanium nanoparticles are toxic to bacteria and have a widespread applications in different fields of
research. Hence the present study aimed to synthesize the titanium dioxide nanoparticles by adopting
green synthesis methodology using Kigelia africana leave extract as a biological reducing agent. The
UV absorption spectra show characteristic absorption maxima corresponding to TiO2 nanoparticles at
a wavelength of 512 nm confirms the formation of nanosized tin particles. The FT-IR spectrum of
TiO2 nanoparticles show absorption bands at 3609 cm-1 and 3227 cm-1 corresponding to O-H stretching
in alcoholic and carboxylic compounds, respectively. Absorption peaks at 1607, 2834, 1654 and 1324
cm-1 correspond to aromatic C=C vibrations, C-H stretching in aldehydes, C-H bending vibrations and
aromatic C-N stretching vibrations, respectively. This confirms the involvement of bioactive compounds
from the plant extract. The SEM and EDX studies confirmed that the nanoparticles are spherical to oval
shape with an average particle size of 46 nm. The metal content in the nanoparticles was found to be
58.71%. The synthesized nanoparticles have potential growth inhibition activity against Gram-negative
bacteria (Pseudomonas aeruginosa and Escherichia coli). The DPPH radical scavenging activity of
the nanoparticles synthesized was compared with that of aqueous leaf extract and standard ascorbic
acid and proved that the nanoparticles have enhanced activity than aqueous leaf extract. The IC50 of
the leaf extract, nanoparticles and the standard was found to be 31.55, 75.82 and 84.95 μg/mL,
respectively. Kigelia africana leaf is shown in this work to be a valuable bioagent in the biosynthesis
of TiO2 nanoparticles with increased biological activity.
Comparative Assessment of Physico-Chemical Results of Air, Water and
Soil Samples Tested at Accredited and Non-accredited Laboratories
Authors: Singh Battal , Chauhan Abhishek , Rawat Manju Ranjan , Verma V.K. , Jindal Tanu
Published: January 2022

There are thousands of results produced by the environmental testing laboratory for the air, water and
soil parameters. The results produced by the environmental testing laboratories are always basis of the
policy decision on various occasions. The results produced by the environmental testing laboratory
provide the basis for the water whether it is fit for drinking purposes or not. The soil of a particular
area is fit for specific agriculture or not. Similarly, the air of a specific location is under the permissible
limit of the required component or not. Over some time the environmental testing laboratories are
increasing in our county and these laboratories can be segregated broadly into two categories namely
accredited laboratories and non-accredited laboratories. The accreditation is done by the independent
authoritative body as per the international standard ISO/IEC 17025. It is believed that the accredited
laboratory has a quality management system and proven technical competence to perform a specific
type of testing. This work presents the comparative studies of the physico-chemical results of air,
water and soil samples tested by accredited and non-accredited laboratories. In case of soil, the pH
and sulfate is tested by the accredited and non-accredited laboratories in the specific environment.
Similarly, construction water and drinking water are tested for various parameters as per the relevant
standard. The air samples were collected from the same site and analysis was done for the various
parameters like PM2.5, PM10 and other toxic gases present in air. It is observed that there is a considerable
difference between the results produced by the accredited and non-accredited laboratories. It is believed
that the results produced by the accredited laboratory are more reliable in comparison to the
non-accredited laboratory.
Pandemia COVID-19 e Ações do Núcleo Ampliado de Saúde da Família e Atenção Básica na Rede SUS
Authors: Coelho Otamares Castro Simões , Ferreira Anelisa Terrola Martins , Mendonça Raquel de Deus
Published: January 2022

O Núcleo Ampliado de Saúde da Família e Atenção Básica (NASF-AB) visa ampliar as ações desenvolvidas pela Estratégia de Saúde da Família. Entretanto, suas atividades sofreram alterações temporárias, devido à pandemia da COVID-19. O objetivo deste trabalho é descrever as atividades e serviços realizados pelos profissionais do NASF-AB de uma regional na rede SUS-BH durante a pandemia de SARS-CoV-2. Trata-se de um estudo transversal com amostra de conveniência em Belo Horizonte-MG. Os dados foram coletados por um questionário online autoaplicado. Participaram 38 profissionais, dos quais 71% atuavam na Atenção Básica há  mais de 5 anos. Na pandemia, observou-se falta de acesso a treinamentos (71%) e equipamentos tecnológicos (53%) para acompanhamento dos usuários. Os grupos operativos foram 100% suspensos e 90% relataram acesso aos Equipamentos de Proteção Individual. Apesar dos desafios que dificultaram a reorganização dos trabalhos e o acompanhamento dos usuários durante eventos excepcionais, o NASF-AB apresenta-se como uma potente estratégia de cuidado.
Controle glicêmico à distância dos idosos diabéticos insulinizados: uma experiência da atuação do Núcleo de Apoio à Saúde da Família (NASF) em tempos de pandemia da COVID-19
Authors: Brasileiro Hélida Maria de Lima Maranhão , Monte Conciana Duarte , Santos Washington José dos , Meira Mateus do Amaral , Pereira Ana Nery Xavier , Ramos Rosa Luiza de Lima , Nascimento Rafaela , Morais Ana Fabrícia , Feitosa Emília Maria Carvalho
Published: January 2022

O Diabetes Mellitus (DM) é um importante problema de saúde mundial. Com o aumento da expectativa de vida, aumenta-se a prevalência da doença com suas complicações crônicas nos idosos. O tratamento efetivo do DM com insulina é complexo e difícil de ser realizado corretamente pelo idoso, pois requer a execução de várias etapas para o preparo e aplicação do medicamento. O Núcleo de Apoio à Saúde da Família (NASF), dentro da sua dimensão clínico-assistencial, realiza educação de saúde em DM, visando práticas seguras para o manejo correto da insulina por parte dos idosos/cuidadores. Com a pandemia da COVID-19, o telemonitoramento foi a estratégia de trabalho utilizada pelo NASF para promover o controle glicêmico dos idosos à distância. A avaliação dos teleatendimentos identificou erros no preparo e aplicação da insulina, verificou o perfil glicêmico dos idosos, permitiu estratificação de risco desses pacientes e reforçou medidas necessárias para a corresponsabilização do cuidado.
A Atenção Primária à Saúde e o enfrentamento à pandemia da COVID-19: um mapeamento das experiências brasileiras por meio da Iniciativa APS Forte
Authors: Fernandez Michelle , Carvalho Wellington , Borges Vanessa , Klitzke Dirceu , Tasca Renato
Published: January 2022

A Iniciativa APS Forte tem como objetivo principal identificar, reconhecer e divulgar boas práticas em Atenção Primária à Saúde que ocorrem no território brasileiro, sistematizando processos e transformando conhecimento tácito em explícito. A partir de uma parceria entre a OPAS/OMS e o Ministério da Saúde, busca-se dar visibilidade e promover iniciativas locais, municipais, regionais ou estaduais gerando conhecimento de forma ascendente e horizontal com vistas ao aumento da cooperação e solidariedade entre os trabalhadores, gestores, usuários e especialistas. O presente artigo tem como objetivo apresentar e descrever a Iniciativa APS Forte realizada em 2020, que foi dedicada a mapear o enfrentamento à pandemia da COVID-19 na APS no Brasil.
A Importância da Educação em Saúde Bucal de Pais e Educadores como Fator de Impacto na Saúde Bucal da Criança: Uma Revisão da Literatura / The Importance of Oral Health Education for Parents and Educators as an Impact Factor on Children's Oral Health: A Literature Review
Authors: Máximo Samara Santos , Aguiar Caique Dos Santos , Pinchemel Edite Novais Borges
Published: January 2022

Resumo: A participação tanto de pais como educadores envolve um impacto surpreendente sobre as mudanças de hábitos da criança. O objetivo deste estudo foi verificar, por meio da literatura, o quanto a participação de pais e educadores como modelos pode impactar nas condições de saúde bucal dessa população. Tratou-se de uma revisão da literatura com pesquisa na base de dados Lilacs, Scielo e Medline; foram selecionadas publicações de 2010 a 2021, perfazendo um total de 27 textos analisados. Assim, a educação em saúde bucal de pais, educadores e responsáveis influencia na saúde bucal da criança e, quanto mais alto for o nível de educação em saúde dos envolvidos, menor será a incidência de doenças que acometem a cavidade bucal, como a cárie e doenças periodontais em crianças.---Abstract: The participation of both parents and educators has a surprising impact on children's changing habits. The aim of this study was to verify, through the literature, how much the participation of parents and educators as role models can impact the oral health conditions of this population. This was a literature review with a search in Lilacs, Scielo and Medline databases; publications from 2010 to 2021 were selected, totaling 27 texts analyzed. Finally, the oral health education of parents, educators and guardians influences the child's oral health and, the higher the level of health education of those involved, the lower the incidence of diseases that affect the oral cavity, such as caries and periodontal diseases in children.Keywords: Oral health education. Literacy in oral health. Pediatric Dentistry.