bluuebunny/crossref_metadata_2025 huggingface dataset:
Pola Komunikasi Penyiar Radio Geronimo 106.1 FM Yogyakarta dalam Menjalin Komunikasi dengan Pendengar
Authors: Khotimah Siti , Agustina Dwi Pela
Published: December 2023

Penelitian ini membahas pola komunikasi penyiar radio Geronimo 106.1FM Yogyakarta dalam menjalin komunikasi dengan pendengar. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana pola komunikasi penyiar radio 106.1FM Yogyakarta berkomunikasi dengan pendengar. Dalam kegiatan penyiaran, peran seorang penyiar sangat dominan mewakili radio dalam menyampaikan informasi dan hiburan menurut pendengarnya. Oleh karena itu, pola komunikasi yang sesuai dengan segmentasi pendengar juga perlu dikuasai oleh penyiar agar pendengar tetap setia mendengarkan Radio Geronimo 106.1FM. Jenis penelitian ini adalah penelitian kualitatif deskriptif dengan menggunakan teori interaksi simbolik. Penelitian ini juga menggunakan pendekatan fenomenologis. Teknik pengumpulan data yang peneliti gunakan adalah wawancara mendalam dan observasi partisipan di Radio Geronimo 106.1FM. Analisis data yang digunakan meliputi reduksi data, penyajian data, penarikan kesimpulan, dan pengujian keabsahan data. Hasil penelitian ini menunjukkan bahwa pola komunikasi radio Geronimo memiliki dua pola komunikasi sekunder dan satu pola komunikasi primer dan mengaitkannya dengan teori interaksi simbolik. Pola komunikasi yang dilakukan oleh penyiar adalah menyesuaikan format siaran yang ditentukan, mulai dari siaran yang santai, seru, humoris, menghibur, serta dengan gaya percakapan dan vokal yang berkarakter. Memutar lagu-lagu hits di awal siaran untuk membahas sapaan di awal siaran, yang kemudian dilanjutkan dengan membaca berita dan informasi menarik yang biasa disebut bridging mastery. Informasi yang dibacakan dengan nyaring, penyiar dituntut untuk dapat membangun Theater of Mind agar pendengar tenggelam dalam esensi siaran serta dapat dengan mudah mencerna dan memahami informasi yang disampaikan.
Emerging Trends in South African Higher Education: A Critical Analysis of Distance Learning Modalities in Music
Authors: Yende Sakhiseni Joseph
Published: December 2023

This study addresses the dynamic shifts in South African higher education, focusing on integrating distance learning into music education. The proliferation of digital platforms has redefined educational paradigms, necessitating a critical examination of its impact on music pedagogy within the South African context. Employing a qualitative critical analysis methodology, this research leverages existing scientific literature to discern patterns, challenges, and opportunities presented by distance learning modalities. Anchored in Jack Mezirow's Transformative Learning Theory, this study investigates emerging trends in distance learning modalities within South African higher education music programmes. Two significant findings emerge: firstly, distance learning fosters student autonomy, enabling self-directed exploration of musical concepts. Secondly, collaborative online environments facilitate cross-cultural musical exchanges, enriching students' cultural understanding and musical proficiency. This study underscores the imperative of harnessing technology for music education in South Africa, emphasising its capacity to democratise access and broaden cultural understanding. The findings contribute to a growing body of literature on transformative learning experiences in music education, offering practical insights for educators and policymakers. As South Africa's educational landscape continues to evolve, this research lays a foundation for the innovative integration of digital platforms, ushering in a new era of inclusive and culturally enriched music education.
PEDAGOGICAL CONDITIONS FOR OVERCOMING THE INDIFFERENCE AND CRUELTY OF TEENAGERS IN THE “BIRTH OF A CITIZEN” BY V.A. SUKHOMLINSKY
Authors:   St. Tikhon Orthodox Humanitarian University, Moscow, Russia, Kuznetsov V.V.
Published: December 2023

The article presents a theoretical analysis of V.A. Sukhomlinsky’s trilogy “The Birth of a Citizen”, aimed at finding pedagogical conditions for overcoming the indifference and cruelty of adolescents. The author presents the problem, topic, its relevance, purpose and objectives of theoretical analysis. The main part of the article gives analysis of scientific sources like a person-centered (K. Rogers), anthropological (L. Feuerbach) and humanistic (Janusz Korczag, etc.) approaches in education, special attention is paid to the philosophy of the heart (A.A. Lebedenko, M.I. Mertsalov, etc.), which allowed modern scientists in the field of education to create cordial pedagogical constructions, which should include the work of Vasily Alexandrovich Sukhomlinsky, which made it possible to prepare the trilogy “The Birth of a Citizen”, in the center of which the reflections of the great teacher, scientist, practitioner about addressing the soul and heart of a pupil in solving complex problems related to overcoming indifference and the cruelty of teenagers.
SPEECH CREATIVITY OF FUTURE TEACHERS: CULTIVATING THROUGH WORDS(IN THE CONTEXT OF V.A. SUKHOMLINSKY’S IDEAS)
Authors:   Orenburg State Pedagogical University, Orenburg, Russia, Zhirnova A.I.
Published: December 2023

The author in his article explores the role and significance of speech creativity in the development of a future teacher and is based on the ideas of the outstanding teacher V.A. Sukhomlinsky devoted to the verbal component of the teaching profession. The study presents a brief analysis of theoretical concepts and practical approaches to the development of speech creativity of a future teacher in the context of modern requirements and the challenge of the educational environment. The analysis was carried out taking into account reliable historical and factually accurate data on the work and experience of V.A. Sukhomlinsky, which included the study of his approaches to upbringing and education, the concept of personality development through the word, as well as real examples of the practical implementation of his ideas in schools and educational institutions. Particular attention is paid to the importance of word education, which allows the teacher to stimulate creative thinking, communication skills and develop the emotional expressiveness of students, which has a positive impact on the results of educational activities. The results of the study confirm that the active development and use of speech creativity in pedagogical practice contributes to the formation of the personal readiness of the future teacher to implement an individual and collective educational process, prevents professional burnout, and allows to quickly adapt to a new audience and any category of the team (parental, work, educational). This article represents an important contribution to the development of speech creativity of future teachers and substantiates the importance of using the ideas of V.A. Sukhomlinsky in pedagogical practice, since the results and recommendations obtained in the course of this study can be used by educational institutions to develop and implement effective programs for the development of speech creativity and improve the quality of domestic education.
THE VIEWS OF V.A. SUKHOMLINSKY TO QUESTIONS OF GIFTEDNESS
Authors:   Orenburg state university, Orenburg, Russia, Kargapoltseva N.A. , D.S. Kargapoltseva ,   Orenburg state university, Orenburg, Russia
Published: December 2023

The article is devoted to the modern state educational paradigm, which focuses on the identification and development of the talents and abilities of each child, which is an important factor for achieving high results in education and in life in general. It is noted that thanks to national projects, more students have the opportunity to use educational platforms of a single high level, as well as equal access for children and youth to competitions that allow everyone to show and develop talents and abilities. One of these projects is Every Child’s Success, which aims to identify, develop and realize abilities. The article also analyzes the Modern School project, which contributes to the modernization of educational institutions and the provision of conditions for obtaining a quality education. The article presents a retrospective analysis of the views of the outstanding Soviet teacher Vasily Alexandrovich Sukhomlinsky on the identification and development of giftedness, talents and abilities of students, who noted that each child is unique and has his own talent. That is why V.A. Sukhomlinsky considered it necessary to create pedagogical conditions for its disclosure and development. An important aspect in the concept of Sukhomlinsky’s views on the upbringing and development of the child is labor, including through which, through diligence and patience, a growing person is given the opportunity to learn how to do something with his own hands, without fail, best of all. The study, comprehension and application of the humanistic views of outstanding representatives of Russian pedagogy in educational activities will certainly allow modern teachers and teachers of preschool and additional education to find a unique approach to recognizing and developing giftedness, talents and abilities of a growing personality.
Identification of Best Practices of Higher Education Leadership in Shaping Student Character following Islamic Guidance
Authors: Rini Fitria  , Abdul Rosid  , Suwarni  , Amirul Syah  , Musyarrafah Sulaiman Kurdi
Published: December 2023

The study aimed to highlight best practices that showcased effective higher education leadership in character development at the university, substantiating these practices with compelling evidence rooted in Islamic principles. In pursuing this objective, a mixed-method approach was employed in the past. Qualitative data was collected through interviews and document analysis, while surveys and questionnaires provided quantitative insights. The study also reviewed relevant literature to contextualize Fatmawati University's character development efforts. The findings from this past study were illuminating. Fatmawati University effectively integrated Islamic ethics and morality into its academic curriculum through courses like "Islamic Ethics and Morality" and "Islamic Principles of Justice." The academic community actively engaged in charitable initiatives, reinforcing compassion and ethical conduct. Inclusivity was promoted through interfaith dialogues and cultural exchange events, fostering tolerance and understanding among students. Additionally, service learning, ethical discussions, and mentorship programs emphasized character development. The university's interdisciplinary approach, integrating Islamic studies across various academic disciplines, facilitated a holistic understanding of character development within Islamic ethics. In summary, Fatmawati University's past best practices in higher education leadership for character development underscored its commitment to Islamic principles, enriching students' character while promoting academic excellence and moral values.
Keywords:  Islamic Ethics, Character Development, Education Leadership
Recurrence of a conjunctival inclusion cyst
Authors: Echieh Chigozie Ifeoma , Dai Vicktoria Vishnevskia
Published: December 2023

Conjunctival cysts are thin-walled benign cystic lesions, lined with a non-keratinising epithelium containing serous fluid. They can cause cosmetic disfigurement, reduced ocular motility and foreign body sensation. The purpose of the study is to report a case of a recurrent conjunctival cyst in a 60-year-old male after drainage. A 60-year-old male was referred to our department with complaints of redness in his right eye for a 3-month duration. There was no history of blurring of vision or ocular trauma. We performed a complete eye examination which showed a visual acuity – 6/6 on both eyes, good ocular motility and pupillary reflexes and slit lamp examination showed on the right eye an oval mobile lesion on the medial bulbar conjunctiva measuring about 3 mm in size which transilluminates. The fundus examination was normal. The drainage attempt of the lesion showed a recurrent growth for several months of a lesion on the same location, and the diameter of the transparent lesion was now 6 mm in size. Anterior segment-optical coherence tomography imaging showed a round lesion with hyporeflective content and a thin hyper-reflective wall. Surgical excision with cryotherapy was carried out. Histopathology showed a two-layered lined conjunctival nonkeratinised epithelium without goblet cells. A diagnosis of a conjunctival inclusion cyst was reported. Surgical excision is a definitive treatment for conjunctival cysts. Recurrence is a major post-operative concern, and thus, a careful and intact removal of the cyst is necessary to prevent recurrence.
Reuse of orthopedic implants in a peri-implant fracture of both forearm bones in an adolescent: A case report
Authors: Aguilar-Chavez Felipe , Jorba-Elguero Pedro , Cruz-Cortés Mónica Alejandra , González-González Fernando
Published: December 2023

Fractures of both forearm bones in adolescents are common. Many of these fractures are surgically fixed with internal fixation. However, among the complications that can occur are peri-implant fractures, which are somewhat infrequent. They are due mainly to high-energy injuries. Therefore, not much information about them is found in the literature. Reusing implants is not a frequent or well-documented practice, and it is carried out only when the necessary resources are unavailable, particularly in developing countries. We are reporting a 16-year-old male patient who suffered a peri-implant fracture distal to plates that were placed 3 years earlier in both left forearm bones. The material was removed successfully and reused, achieving an adequate reduction and fixation with one dynamic compression plate (DCP) plate for the radius and one reconstruction plate for the ulna. The patient recovered successfully. This case report aimed to understand the lack of resources in a developing country and a possible solution for this problem in this type of scenario.
Free amino acid profiling and quantification of 4-hydroxyisoleucine in Trigonella foenum-graecum (fenugreek) seeds treated with Trichoderma viride and rhizobium
Authors: Addala Haritha , Pappu Lalitha
Published: December 2023

Fenugreek is a legume but regarded as a poor nitrogen fixer. The present study deals with the marked effect of Trichoderma viride and rhizobium on quantification of 4-hydroxyisoleucine content and free amino acid composition of fenugreek seeds. 4-hydroxyisoleucine is regarded as an antidiabetic compound present specifically in fenugreek plants. Fenugreek seeds treated with both T.viride and rhizobium boosted free amino acid concentration and 4-hydroxyisoleucine content compared to control and positive control (NPK treated). Seeds were treated with T.viride suspension (107 spores/seed), rhizobium suspension (108 cells/seed) , combination of T.viride and rhizobium suspension in equal amounts (0.5ml of T.viride  0.5ml of rhizobium suspension /seed), NPK suspension ( 1ml NPK suspension / seed) and untreated seeds (1 ml distilled water/ seed) serving as control sown in pots filled with potting soil and also in a randomized plot ( 55 feet) in the field. In free amino acid composition, isoleucine is the precursor for 4-hydroxyisoleucine compound and its concentration was enhanced by 47.79 % (potted plants) and 26.46 % (field plants) over control and by 27.02 % (potted plants) and 13.03 % (field plants) over positive control. 4-hydroxyisoleucine content was quantified using LCMS method in both potted and field plants. An increase of 37.02 % (potted plants) and 23.61 % (field plants) in 4-hydroxyisoleucine concentration in dual treated plants over control and positive control was observed.
Distinct antibacterial and antioxidative properties of Couroupita guianensis Aubl. plant parts and their relation with polyphenolic contents
Authors: Bhattacharya Rupsa , Sikdar Bratati , Mukherjee Sourav , Raj Adarsha , Roy Sudipta
Published: December 2023

Couroupita guianensis is an arboreal flowering plant of the family Lecythidaceae with diverse pharmacological effects and a myriad of folk-medicinal uses. The study aims to compare the antibacterial and antioxidant efficacies of different plant parts like bark, leaf, flower and fruit with their polyphenolic contents. Methanolic extracts of different plant parts were prepared to assess their bioactivities and to estimate phytochemicals. The antibacterial activities of different extracts against six pathogenic bacteria were examined following the agar diffusion method and broth microdilution assays to determine inhibition zones, MIC and MBC. Among the different plant parts, the fruit methanolic extract represented the highest antibacterial activity with the highest inhibition zones and consequential lowest MIC/MBC values. On the contrary, the antioxidant activities revealed the superiority of bark over other plant parts in the total antioxidant, ferric reducing and radical scavenging assays. Phytochemical analyses by qualitative assays and HPTLC highlighted the presence of diverse phytocomponents in different extracts. Among different plant parts, quantitative estimates of polyphenolic contents exhibited the highest total phenolics (TPC; 37.32±2.47 mg GAE/g extract) in bark, the highest flavonoid content (TFC; 25.78±1.56 mg QE/g extract) in flower while the highest tannin content (TTC) was noted in leaf (34.35±0.40 mg GAE/g extract). Pearson’s correlation analyses concerning the polyphenolic contents and the bioactivities like antioxidant and antibacterial efficacies in different plant parts highlighted an explicit role of total phenols and flavonoids in the antioxidative properties. However, the role of polyphenols in the antibacterial activities of Couroupita was meager and pointed out the involvement of non-phenolic compounds in such activities. Despite the low polyphenol contents in Couroupita fruit extract, its potent antibacterial activities have grown our interest in future studies to find out the bioactive compound(s) with therapeutic potential.
MSSA Infection Due to Cardiac Device
Authors:   Department of Internal Medicine, Marshfield Clinic, USA, Elkhedr Ali EA , Elkhidir Sabri ,   Department of Internal Medicine, Marshfield Clinic, USA
Published: December 2023

Background: we present a 67-year-old male with a history of coronary artery disease and congestive heart failure. He had undergone implantation of an ICD one year ago. Around a year later, he presented with localized discharge, erythema, and swelling around the ICD pocket site. He denied fever, fatigue, and increased shortness of breath. Infectious disease service performed US guided fluid aspirate and culture which tested positive for MSSA. He started him on prolong regimen of cephalexin for a month without improvement. Recommendations were made then for device removal. Case Report: After explanation, the patient’s symptoms improved with antibiotic therapy and the wound showed signs of healing. The infection was successfully eradicated, and the patient’s cardiac function stabilized. The patient was discharged on oral antibiotics for an additional four weeks and scheduled for regular follow-up visits. Conclusion: This case report highlights the occurrence of a cardiac implants pocket infection. Early diagnosis, prompt removal of the infected device, and targeted antibiotic therapy were crucial in achieving successful treatment outcomes. Surgical debridement and wound irrigation played a vital role in preventing further complications. Close monitoring and follow-up are essential to ensure complete resolution of the infection and prevent recurrence.
Quantitative Study, Induction of Labour at Mildura Base Public Hospital, Mildura, a Regional City in North-West Victoria, Australia
Authors:   Department of Obstetrics & Gynecology, Mildura Base Public Hospital, Australia, Aboda Ayman , Aali Shahnaz ,   Department of Obstetrics & Gynecology, Mildura Base Public Hospital, Australia, McCully Brian ,   Department of Obstetrics & Gynecology, Mildura Base Public Hospital, Australia
Published: December 2023

This report discusses Induction of Labour induction (IOL), its global prevalence, and techniques that may be utilised. It provides a critical review of their comparative effectiveness and clinical outcomes. It also provides a perspective of regional Australian hospital practice, demonstrating the implications of induction of labour before and after the COVID pandemic.
Innovative Wound Dressing Coated with Drug-Loaded Adipose Mesenchymal Stem Cells to Promote Wound Healing in Diabetes
Authors:   Department of Infectious Diseases, No. 4 People’s Hospital, Zibo, China, Bao Yinglin , Liu Feng ,   Department of Medical Images, The Affiliated Hospital of Weifang Medical University, China, Xia Qing ,   Department of Medical Images, The Affiliated Hospital of Weifang Medical University, China, Luan Qingxia ,   Department of Pediatrics, The Affiliated Hospital of Weifang Medical University, China, Ammar Albandri Bin ,   Department of Clinical Nutrition, College of Applied Medical Science, University of Hail, Saudi Arabia, Ahmed Nessar ,   Department of Life Sciences, Manchester Metropolitan University, UK, Slevin Mark ,   Department of Life Sciences, Manchester Metropolitan University, UK, Ali Kamela ,   Yanbu College of Applied Medical Sciences, Taibah University, Saudi Arabia, Liu Donghui ,   Department of Life Sciences, Manchester Metropolitan University, UK
Published: December 2023

Impaired wound healing is associated with hyperglycaemia in patients with diabetes. Hyperglycaemia induces protein glycation and the formation of Advanced Glycation End-Products (AGEs). The accumulation of AGEs in the body results in the structural and functional modification of tissue proteins. This study was conducted to evaluate compounds with antiglycation activities (S-Ally1 Cysteine (SAC), N-Acetylcysteine (NAC) and the mimic compound A). The extent of glycation in the presence and absence of several inhibitors was assessed via several methods including fluorescence, Sodium Dodecyl Sulphate-Polyacrylamide Gel Electrophoresis (SDS-PAGE)- silver stain, Western blotting, and Enzyme-Linked Immunosorbent Assays (ELISA). Additionally, this research aimed to evaluate and quantify the potential of Human Adipose Mesenchymal Stem Cells (hADMSCs) to uptake and release these drugs as potential therapeutics. To achieve this, hADMSCs were primed with a combination of SAC/NAC and mimic compound A and their concentrations were analysed using High-Performance Liquid Chromatography (HPLC). The SAC/NAC and mimic compound A prohibit the formation of AGEs while the Conditioned Medium (CM) from SAC/NACand compound A-loaded hADMSCs induced cell migration and tube formation in BAECs. hADMSCs provide a unique opportunity for the development of an innovative targeting and drug-delivery system which could effectively deliver therapeutics to specific regions of wounds or other damaged tissues. The data provided demonstrate the potential of hADMSCs as a drug delivery method with the potential to improve wound healing, and it may offer potential therapeutic targeting for the development of diabetic complications.
Agext and Its Active Compounds as Potential Therapeutic Prevention against Atherosclerosis and Cardiovascular Disease
Authors:   The Affiliated Hospital of Weifang Medical University, Shandong, China, K Liu , Y Mi ,   Department of Pharmacy, The First Affiliated Hospital, Weifang Medical University, Shandong, China, Y Bao ,   No.4 People’s Hospital of Zibo, Shandong, China, Q Luan ,   The Affiliated Hospital of Weifang Medical University, Shandong, China, Y Liu ,   Faculty of Medical Images, Weifang Medical University, Shandong, China, M Zhang ,   Faculty of Medical Images, Weifang Medical University, Shandong, China, AB Ammar ,   College of Applied Medical Science, University of Hail, Saudi Arabia, K Ali ,   Yanbu College of Applied Medical Sciences, Taibah University, Saudi Arabia, A Elosta ,   Department of Life Sciences, Manchester Metropolitan University, Manchester, M1 5GD, UK, M Lin ,   Faculty of Medical Images, Weifang Medical University, Shandong, China, N Ahmed ,   Department of Life Sciences, Manchester Metropolitan University, Manchester, M1 5GD, UK, M Slevin ,   Department of Life Sciences, Manchester Metropolitan University, Manchester, M1 5GD, UK, F Liu ,   Faculty of Medical Images, Weifang Medical University, Shandong, China, D Liu ,   Department of Life Sciences, Manchester Metropolitan University, Manchester, M1 5GD, UK
Published: December 2023

Advanced Glycation End-Products (AGEs) have been implicated in the chronic complications of Diabetes Mellitus (DM) and play an important role in the pathogenesis of atherosclerosis in human arteries. The main active compounds found in Aged Garlic Extract (AGExt) are S-Allyl Cysteine (SAC), N-Acetylcysteine (NAC) and S-allyl Mercaptocysteine (SAMC) and have powerful protective effects against oxidative stress and inhibit cellular damage by AGEs. Aims: To explore the effect of AGExt on the development of atherosclerosis also investigated the endothelial protective effects of AGExt, using Human Coronary Artery-Derived Endothelial Cells (HCAEC). The use of an optimised mixture of the above compounds required to obtain and provide maximal beneficial effects against oxidative stress, cell apoptosis and protein glycation. Results: AGExt has protective effects against the cellular damage of HCAEC. In addition, the in vivo study accessed the activity of SAC and NAC to reduce the severity of atherosclerosis formation in Apolipoprotein (ApoE-/-) DM model mouse. The compounds of AGExt in vitro had strong protective actions against the AGEs induced damage to ECs even at low concentrations (100 ng/ml). Such low concentrations may have therapeutic usefulness in patients with diabetes.
Place and role of science-intensive business segments in vertically integrated oil and gas companies
Authors: Kachalkina K. G.
Published: December 2023

Oil and gas industry development is influenced by global trends, which are mostly negative and restrictive in nature. Improvement and applied use of scientific resources are some of the key factors that allow us to respond to the challenges. The relevance of knowledge-intensive business segment development is noted by the industry expert community. The current versions of the Energy Strategy and the Strategy for Scientific and Technical Development of Fuel and Energy Sector Industries include tasks of developing import-substituting technologies and equipment, conducting R&D for this purpose, and improving scientific competencies. These tasks are translated into the strategies of individual vertically integrated oil and gas companies, and, therefore, there is a need to analyze the place and role of knowledge-intensive business segment of such companies in order to assess its ability to ensure their strategic sustainable development. According to the analysis results, importance of knowledge-intensive business segment for strategic sustainable development of oil and gas companies has been confirmed. The need to actualize the tools and methods of strategic planning for knowledge-intensive segments development in order to align activity to create scientific results with formalized goals and challenges of company development has been identified.
Russian industrial production development
Authors: Titov A. K.
Published: December 2023

The study assesses main factors affecting successful processes of industrial production in Russian regions in recent times. It considers the unfavorable effects of the pandemic and sanctions on industrial enterprises production. The discussion centers on the examination of industrial production in modern Russia and forecasting its further development. The introduction presents a review of scientific literature of financial experts and researchers studying the phenomena of industrial production. The purpose of the study is to examine the state of industrial production development in Russia considering regional economic evolution under sanctions. An exhaustive assessment of the factors determining industrial development, as well as main economic indicators of industrial companies’ performance, has been carried out. The article also includes a study of the works of scientists who participated in assessing this issue from both domestic and foreign points of view. Special attention has been paid to the factors that characterize the industrial production cycle in Russia and its regions. In conclusion, the author summarized the results of the conducted research and review of scientific materials. The essence of this generalization is to endorse continuous transformation of regional industrial production management in the future. Proposals for sustainable development of industrial production in the long term have also been put forward.
Identifying potential threats to economic security in a commercial organization
Authors: Ageeva O. A. , Matytsyna Yu. D.
Published: December 2023

The article reveals methods of identifying potential threats to economic security of commercial organization, primarily the algorithm of express diagnostics of its financial and economic activities. The purpose of the study is to identify threats to economic security of commercial organization and to build an algorithm to eliminate them with the help of internal control tools. The objectives are to conduct a financial analysis of organization, to systematize main indicators subject to evaluation, to identify the most significant threats and, as a consequence, to develop measures to strengthen economic security of commercial organization. The methodology of the research consisted in generalizing existing internal control toolkit, as well as in developing recommendations to improve economic security of commercial organization. The internal control methodology developed by the authors and presented in the article to identify and eliminate threats to economic security of commercial organization differs from existing similar methods in that it supplements internal threats with a new specific type of threats, on the one hand, arising externally, and on the other hand – affecting commercial organization directly at the micro level. It has been proposed to eliminate such threats with the help of the internal control system by expanding its tools.
Adaptation of the Russian enterprises activities to sanctions restrictions
Authors: Panova E. A.
Published: December 2023

Anti-Russian sanctions represent a large-scale range of restrictions imposed by the coalition of countries. They include blocking financial, investment, import, and export operations with Russia. The sanctions have affected almost all economic entities, even those not directly dependent on foreign markets. The purpose of the study is to identify main areas of the sanctions impact on Russian enterprises in combination with a set of adaptation measures to the restrictions imposed. The study is based on the methods of comparative analysis, generalization, and systematization. The article considers difficulties faced by enterprises after the sanctions introduction and ways of building new business relationships with counterparties from “friendly” countries. The results obtained can be useful for enterprises of various activity spheres when solving issues of increasing commodity flows and improving economic results under the current conditions.
Illegal imports of tobacco and tobacco products into Russia from the EAEU countries: assessment and areas of minimization
Authors: Salnikova A. V. , Goryacheva D. D.
Published: December 2023

Tobacco and tobacco products are in demand in Russian domestic market, which is characterized by shadow segment growth in recent years. Main share in Russian shadow tobacco market structure is represented by imported and counterfeit products. The article assesses the scale of illegal importation of tobacco and tobacco products into Russia from the Eurasian Economic Union countries (hereinafter – EAEU) in 2018–2022. The authors consider the factors contributing to illegal imports of tobacco products growth from the territories of the EAEU member states. The urgent problems of counteracting violation of the order of tobacco and tobacco products importation from the union states have been identified. Measures aimed at ensuring legality of mutual trade in the goods under consideration within the EAEU and reducing the volume of their illegal import into Russia from the territories of the Union member states have been proposed.
Role of emotional intelligence in PR specialist’s career
Authors: Musatova S. A.
Published: December 2023

The article studies the relevance of the problems of emotional intelligence (EI) in the framework of PR-specialist’s career. The article presents concepts of emotional intelligence from the point of understanding specifics of the phenomenon, considers the typology of EI models, and investigates the problem of measuring emotional intelligence and prospects for developing this type of intelligence in PR-specialists. Emotional intelligence is a person’s ability to recognize and understand their own emotions, explain them, and, using the same ability, understand emotional reactions of others. The role of EI in PR-specialist’s career from the point of competence approach to professional activity has been considered. Vacancies content analysis data with employers’ requirements to the PR-specialist position have been compiled, table of references to personal qualities that can be attributed to the EI sphere made, and theoretical analysis of emotional intelligence carried out.
Designing in students’ training in the field of law
Authors: Titor S. E.
Published: December 2023

According to the Ministry of Labor and Social Protection of the Russian Federation, there is an opinion among leading employers that only 8 % of professional educational organizations graduates are fully prepared to perform their job duties. Modern economy, especially in the stage of import substitution and sanctions, requires a strong and highly qualified competitive employee. Modern vocational education has special requirements, it needs transformation. Professional competencies of modern graduates continue to be the center of attention. Continuous development of techniques and technologies requires mobility, flexibility, and timely actualization from professional education. The study analyzes experience of Law project training of students as a way to increase the demand for law graduates in labor market. The analysis has been conducted on legal specialists training.
Amplification of factors of regional markets transformations in the context of generation theory
Authors: Blizkiy R. S. , Divaeva E. A.
Published: December 2023

The article summarizes scientific ideas about essence of Russian regions and regional markets as actively transforming systems of economic relations in complex geopolitical and socio-economic conditions. The authors propose a process-role model of Russian regional markets functioning, consider relationship and dependence of median number and age structure of the country’s population, highlight the dominant problem of aging and decline in the number of able-bodied population. The researchers propose to consider combinatorics of the generations theory factors within the framework of Russian regional markets development. The research achievement consists in theoretical and methodological provisions development justifying amplification of market development factors considering different archetypes of consumer generations, consumer triggers presented, as well as regulatory aspects of regional policy aimed at strengthening the all-Russian civil identity and social stability in society. Methods of scientific research: system analysis, synthesis, economic and statistical method, methods of abstraction and inductive logic. The purpose of the study is to determine the content of regional markets meaning on the basis of the analysis of Russian regional markets regularities of transformations and corresponding regional specifics, to develop a process-role model considering existing paradigms of regional economy, realizing the dilemma of contradictions of consumers generations, business and state in the demands, values, and space of the market, entailing causal relationship of amplification of Russian markets transformation factors. The scope of application of the results obtained is multifaceted – from market infrastructure organizations to state structures. The latter will find the results useful in implementing state programs.
Real Shear Thickening Fluid (STF) Flow in Converging-Diverging Channels: Analytical and Lattice Boltzmann Study
Authors: Vishal Garima , Garg Ashish , Sarkar Jayati , Pattanayek Sudip Kumar
Published: December 2023

Experimentally, a Shear Thickening Fluid (STF) combines parts-wise Newtonian, shear thinning, and shear thickening regions in the viscosity-shear rate plot. The flow characteristics of the STF fluids through the complex geometries of narrow space are essential in developing impact-resistant systems. Here, we have used the mesoscopic numerical simulation technique, the Lattice Boltzmann method (LBM), in a D2Q9 framework to study the flow characteristics of a real shear thickening fluid through converging-diverging channels. In addition, we have developed a theory based on the lubrication assumptions in the shallow cross–section of the channels. We compare the numerical results with the theoretical results for the flow of Newtonian and non-Newtonian fluids through converging-diverging conical channels followed by uniform height channels. Numerical results indicate sizable differences in the pressure distribution in the converging-diverging regions. The difference in the theoretical calculations and numerical predictions depends on the viscosity and angle of the converging and diverging sections. Further, we compare the effect of the flow of a real STF through the above channels. We find that the pressure drop is higher near the throat region than the uniform part of the channel, and consequently, shear rates are high. Due to that thickening, fluid flow happens in the throat region, which gets further displaced towards the outlet of the channel. The theory also gives approximately similar predictions as found by the LBM study.
Hexahydropyrrolo-[2,3-b]-indole Containing Alkaloids as a SARS-CoV-2 Inhibitors: An Integrated Multi-Target Based in-silico Approach
Authors: Mandal Debasish
Published: December 2023

The discovery of potential drug molecules which can inhibit multiple targets at a single shot is extremely efficient in combating modern diseases. In continuation of this effort, this manuscript represents a multi-targeted based virtual screening approach aimed at identifying the most promising natural alkaloids based on Hexahydropyrrolo-[2,3-b]-indole backbone as a potential inhibitor against SARS-CoV-2. In this pursuit, eight traditional and understudied SARS-CoV-2 viral targets like the main protease (Mpro), RNA polymerase (RdRp), Envelope protein (Evp), Receptor binding domain (S-RBD), Human receptor angiotensin (hACE2), Spike protein, uridine specific endoribonuclease (nsp15) and capping protein (nsp16) are selected. The virtual screening of a series of naturally occurring alkaloids across these eight binding sites of SARS-CoV-2 proteins demonstrated great binding affinity. In fact, these sets of small natural product molecules highlight similar or greater binding affinity with multiple proteins compared to traditional-approved drugs like Ramdesivir, Nirmatrelvir and Molnupiravir. Based on the ADMET profiling, it can be verified that these sets of natural products exhibit the optimal pharmacokinetic parameters. Furthermore, analysis of the key amino acid-ligand interactions and time-dependent DFT calculation of top leads support the possibility of the multi-targeting capability of these moieties to fight persistently against the rapidly evolving SARS-CoV-2.
Recent Advancement in Synthesis of Isothiocyanates
Authors: Maeda Bumpei , Murakami Kei
Published: December 2023

Isothiocyanates exhibit various biological characteristics, including antimicrobial, anti-inflammatory, and anticancer properties. Their significance extends to synthetic chemistry, where they serve as valuable platforms for versatile transformations. Consequently, they have attracted the attention of biologists and chemists. This review summarizes recent advancements in the synthesis of isothiocyanates. Access to a variety of starting materials is important to prepare isothiocyanates with diverse structures. This review categorizes synthetic methods into three types based on the starting materials and functional groups: (i) Type A, derived from primary amines; (ii) Type B, derived from other nitrogen functional groups; and (iii) Type C, derived from non-nitrogen groups. Recent trends in synthetic methods have revealed the prevalence of type-A reactions derived from primary amines. However, Type B reactions have rarely been reported. Notably, over the past four years, there has been a notable increase in Type C reactions, indicating a growing interest in non-nitrogen-derived isothiocyanates. Overall, this review not only outlines the advancements in the synthesis of isothiocyanates but also highlights trends in the methodology.
A Mechanism to Open Academic Chemistry to High-Throughput Virtual Screening
Authors: Bedart Corentin , Shimokura Grace , West Frederick G , Wood Tabitha E , Batey Robert A , Irwin John J , Schapira Matthieu
Published: December 2023

Computationally screening chemical libraries to discover molecules with desired properties is a common technique used in early-stage drug discovery. Recent progress in the field now enables the efficient exploration of billions of molecules within days or hours, but this exploration remains confined within the boundaries of the accessible chemistry space. While the number of commercially available compounds grows rapidly, it remains a limited subset of molecules that could be synthesized. Here, we present a workflow where chemical reactions typically developed in academia and unconventional in drug discovery are exploited to dramatically expand the chemistry space accessible to virtual screening. We use this process to generate a first version of the Pan-Canadian Chemical Library, a collection of nearly 150 billion diverse compounds that does not overlap with other ultra-large libraries such as Enamine REAL or SAVI and could be a resource of choice for protein targets where other libraries have failed to deliver bioactive molecules. A 127 million compound subset of the library is available at https://pccl.thesgc.org/.
Stöber Method to Amorphous Metal Organic Frameworks
Authors: Zhang Wei , Liu Yanchen , Jeppesen Henrik , Pinna Nicola
Published: December 2023

The Stöber method is a widely-used sol-gel route for synthesizing amorphous SiO2 colloids and conformal coatings. Recently, further enrichment of this methodology has been achieved by extending it to other materials such as TiO2 and a resorcinol–formaldehyde polymer. Nonetheless, there are still limited materials that can be synthesized by the Stöber method. Herein, by mimicking the Stöber method, we have extended the approach to metal organic frameworks (MOFs), a category of organic-inorganic hybrid materials with exceptionally customizable composition and properties. It is important to note that amorphous MOFs have demonstrated unique performances in energy storage and conversion and drug delivery applications, but achieving controllable synthesis has remained a challenge. Herein, we introduce a general synthesis route to amorphous MOFs by making use of a vapor diffusion method, which allows to precisely control the growth kinetics. Twenty-two different amorphous MOF colloids were successfully synthesized by selecting 11 metal ions and 17 organic ligands. Moreover, by introducing pre-formed core-nanoparticles (NPs), a conformal and homogeneous amorphous MOFs coating with controllable thickness can be grown on core-NPs to form core-shell colloids. The versatility of this amorphous coating technology was demonstrated by synthesizing over 100 new core-shell composites from 19 amorphous MOF shells and over 30 different core-NPs. Besides, various multifunctional nanostructures, such as conformal yolk-amorphous MOF shell, core@metal oxides, and core@carbon, can be obtained through one-step transformation of the core@amorphous MOFs. This work significantly enriches the Stöber method and introduces a platform, enabling the systematic design of colloids exhibiting different level of functionality and complexity.
Statistical modelling and analysis of NCEA and New Zealand Scholarship assessment data
Authors: Johnston Michael , Lillis David
Published: December 2023

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The New Zealand Association of Scientists Awards for 2011
Authors: Editors
Published: December 2023

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Nurturing genius: the childhood and youth of Kelvin and Maxwell
Authors: Lekner John
Published: December 2023

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Principles of scientific method
Authors: Popper Karl
Published: December 2023

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Analisis Faktor Risiko Serangan Stroke Berulang pada Pasien Usia Produktif
Authors: Firuza Kencana Noor , Khamsiyati Siti Istiqomah , Lahdji Aisyah , Yekti Murwani
Published: December 2023

Latar Belakang:Perubahan zaman menyebabkan perubahan gaya hidup yang tidak sehat. Perubahan gaya ini meningkatkan insidensi stroke yang kini telah merambah ke usia produktif. Stroke sendiri dapat mengalami rekurensi apabila tidak ada perubahan pola hidup pasien dimana stroke berulang ini lebih fatal meningkatkan morbiditas dan mortalitas. Stroke yang dialami pasien dengan usia produktif berdampak negatif terhadap kinerja dan mengurangi angka produksi kinerja di usia produktif. Metode:Penelitian ini menggunakan desain kasus kontrol pada catatan rekam medis pasien terdiagnosis stroke di usia produktif 15 - 64 tahun selama periode Januari 2018-Desember 2020. Kelompok kasus adalah pasien stroke berulang. Kelompok kontrol adalah pasien stroke primer. Perbandingan sampel kelompok kasus dan kontrol adalah 1 : 1 yaitu dengan total sampel sebesar 66 partisipan. Kedua kelompok ditelaah variabel jenis kelamin, riwayat hipertensi, diabetes melitus dan dislipidemia.Hasil:Hasil penelitian menunjukkan bahwa seluruh populasi pasien dengan hipertensi terdapat hubungan bermakna (p<0,05; OR = 2,941) dengan kejadian stroke berulang. Pada seluruh populasi pasien dengan dislipidemia terdapat hubungan bermakna (p<0,05; OR = 3,750) dengan kejadian stroke berulang di pasien stroke usia produktif. Pada faktor risiko diabetes melitus dan jenis kelamin tidak terdapat hubungan bermakna antara kedua faktor risiko tersebut dengan kejadian stroke berulang. Kesimpulan:Terdapat hubungan antara riwayat hipertensi dan dislipidemia terhadap serangan stroke berulang di usia produktif. Diabetes dan jenis kelamin menunjukkan hubungan terhadap kejadian stroke berulang.
Hubungan Ekspresi LMP-1 dengan Overall Survival Pasien Diffuse Large B-Cell Lymphoma di RSUP Dr Kariadi Semarang
Authors: Hamidiyah Silpi , Sadhana Udadi , Istiadi Hermawan , Karlowee Vega , Miranti Ika Pawitra
Published: December 2023

Latar Belakang: Latent membrane protein 1 (LMP1) merupakan onkoprotein abnormal yang paling utama ditemukan pada infeksi virus Epstein-Barr (EBV). LMP1 sering terekspresi pada berbagai keganasan terkait EBV, salah satunya adalah diffuse large B cell lymphoma (DLBCL). Beberapa literatur telah menjelaskan keterlibatan EBV terhadap outcome klinis pasien namun nilai prognostik dari ekspresi LMP1 terhadap overall survival pasien DLBCL terkait EBV masih belum dapat dijelaskan.Metode: Penelitian dengan desain cross sectional ini melibatkan 50 pasien DLBCL yang didiagnosis antara Januari 2017 sampai Juni 2018. Pengamatan dilakukan selama 60 bulan. Data yang dikumpulkan meliputi usia, gejala B, stadium tumor, subtipe molekuler, dan survival 5 tahun. Analisis data menggunakan uji beda dan kurva Kaplan-Meier.Hasil: Dari 50 pasien, sebagian besar berusia diatas 40 tahun (88%), jenis kelamin laki-laki (60%), subtipe non GCB (62%), mengeluhkan semua gejala B (30%) dan stadium I (38%). Sebanyak 21 pasien meninggal (42%). Pasien dengan skor LMP1 yang tinggi menunjukkan overall survival yang lebih buruk secara bermakna dibandingkan dengan skor LMP1 yang rendah (P <0.001).Kesimpulan: DLBCL yang mengekspresikan LMP1 berhubungan dengan rendahnya overall survival 5 tahun dibandingkan dengan yang tidak mengekspresikan LMP1.