bluuebunny/crossref_metadata_2025 huggingface dataset:
Análisis histórico-crítico del discurso de la política pública de las pesquerías de abulón en la península de Baja California, México (periodo analizado 1947-1993)
Authors: Lagunas-Vazques Magdalena , Beltrán-Morales Luis Felipe , Ortega-Rubio Alfredo
Published: September 2018

En este artículo se presenta un análisis histórico-crítico de un periodo de 80 años enfocado en el discurso sobre las regulaciones de la pesquería de abulón en México, cuyo objetivo es describir esta actividad comercial y analizarla en un contexto amplio. Para ello, se realiza una revisión de bibliografía especializada y de instrumentos jurídico-normativos; asimismo, se emplea el análisis crítico del discurso y la historia conceptual. Entre los resultados obtenidos, destaca la notoria separación del discurso político en dos periodos, así como la identificación de las transformaciones y de la legitimación de un discurso que desplaza al sector en este periodo. Una de las limitaciones de la investigación fue la falta de datos empíricos desde los actores principales, es decir, los pescadores. La originalidad del estudio se centra en que no existía a la fecha una investigación sobre el análisis crítico del discurso de la pesquería de abulón, pese a que es una pesquería importante socioeconómica y ambientalmente en México. Finalmente, como hallazgo, se puede afirmar que, en la conceptualización histórica, el corpus se puede dividir en dos periodos, y se identificaron transformaciones paulatinas y la legitimación del discurso.
El efecto mediador de la satisfacción laboral en la relación entre la percepción de oportunidades de empleos alternativos y el compromiso organizacional. Un estudio de caso en una maquila tamaulipeca
Authors: Herrera Ledesma Pedro Alberto , Sánchez Tovar Yesenia , Sánchez Limón Mónica Lorena
Published: September 2018

El artículo tiene por objetivo analizar si la satisfacción laboral ejerce un efecto mediador enla relación entre la percepción de alternativas de empleo y el compromiso organizacional en laindustria maquiladora. Para verificar el modelo estadístico se realizó una prueba empírica con 145 operadores de línea en una maquiladora de insumos electrónicos en Victoria, en el estado de Tamaulipas (México). La base datos fue analizada por medio del programa estadístico SPSS. Entre los resultados, se establece que, aunque la percepción de alternativas de empleo afecta de manera negativa el compromiso organizacional, este efecto es mediado totalmente por la satisfacción laboral. El valor de este trabajo radica en que es la primera investigación de este tipo en el mercado laboral de la industria maquiladora. En conclusión, se determina que el efecto de la percepción de alternativas de empleo no es directo, sino indirecto; esto debe alentar a las gerencias de recursos humanos para esforzarse en reducir los comportamientos opuestos al compromiso organizacional. En otras palabras, aunque la percepción de ofertas externas de otros posibles empleadores influye en la decisión de rechazar el compromiso organizacional, es la satisfacción laboral la que finalmente determina la decisión de establecer o no establecer un compromiso organizacional con el actual trabajo.
Carlota de Bélgica. Emperatriz de México
Authors: Ciaramitaro Fernando , García Ávila Jesús
Published: September 2018

Reseña del libro Carlota de Bélgica. Emperatriz de México
Análise qualitativa de notícias veiculadas na mídia impressa sobre dieta alimentar e saúde bucal
Authors: Novaes João Paulo de Almeida , Justo Glaucia Figueiredo , Silva-Junior Manoelito Ferreira , Cavaca Aline Guio , Oliveira Adauto Emmerich
Published: September 2018

Qualitative analysis of print media reports about diet and oral health
Duas faces do mesmo Sistema? Um estudo dos sentidos do Sistema Único de Saúde no jornal Diário do Nordeste
Authors: Cavalcante Clarisse Castro , Lerner Kátia
Published: September 2018

Two sides of the same System? A study of the senses of ‘Sistema Único de Saúde’ in Diário do Nordeste newspaper
Alimentação saudável na mídia de massa e promoção da saúde: percepções sociais de agentes comunitários
Authors: Barros Ione Silva , Costa Mariella Silva de Oliveira , De Oliveira Roberto Carlos , Santa Barbara Rehem Tania Cristina Morais , De Sousa Maria Fátima , Mendonça Ana Valéria Machado
Published: September 2018

Healthy eating in the mass media and health promotion: social perceptions of community agents
Zika e publicidade: reflexões sobre comunicação de risco e emergência em saúde na perspectiva das indústrias culturais e midiáticas
Authors: Antunes Michele Nacif , Oliveira Adauto Emmerich , Rebouças Edgard
Published: September 2018

Zika and press releases: reflections on the communication of risk and emergency under the perspective of culture and media industries
Targeting Nodal and Cripto-1: Perspectives Inside Dual Potential Theranostic Cancer Biomarkers
Authors: Sandomenico Annamaria , Ruvo Menotti
Published: September 2018

Background:

Elucidating the mechanisms of recurrence of embryonic signaling pathways in tumorigenesis has led to the discovery of onco-fetal players which have physiological roles during normal development but result aberrantly re-activated in tumors. In this context, Nodal and Cripto-1 are recognized as onco-developmental factors, which are absent in normal tissues but are overexpressed in several solid tumors where they can serve as theranostic agents.

Objective:

To collect, review and discuss the most relevant papers related to the involvement of Nodal and Cripto-1 in the development, progression, recurrence and metastasis of several tumors where they are over-expressed, with a particular attention to their occurrence on the surface of the corresponding sub-populations of cancer stem cells (CSC).

Results:

We have gathered, rationalized and discussed the most interesting findings extracted from some 370 papers related to the involvement of Cripto-1 and Nodal in all tumor types where they have been detected. Data demonstrate the clear connection between Nodal and Cripto-1 presence and their multiple oncogenic activities across different tumors. We have also reviewed and highlighted the potential of targeting Nodal, Cripto-1 and the complexes that they form on the surface of tumor cells, especially of CSC, as an innovative approach to detect and suppress tumors with molecules that block one or more mechanisms that they regulate.

Conclusion:

Overall, Nodal and Cripto-1 represent two innovative and effective biomarkers for developing potential theranostic anti-tumor agents that target normal as well as CSC subpopulations and overcome both pharmacological resistance and tumor relapse.
Complex Signaling Networks Controlling Dynamic Molecular Changes in Pseudomonas aeruginosa Biofilm
Authors: Guła Grzegorz , Dorotkiewicz-Jach Agata , Korzekwa Kamila , Valvano Miguel A. , Drulis-Kawa Zuzanna
Published: September 2018

The environment exerts strong influence on microbes. Adaptation of microbes to changing conditions is a dynamic process regulated by complex networks. Pseudomonas aeruginosa is a life-threating, versatile opportunistic and multi drug resistant pathogen that provides a model to investigate adaptation mechanisms to environmental changes. The ability of P. aeruginosa to form biofilms and to modify virulence in response to environmental changes is coordinated by various mechanisms including two-component systems (TCS), and secondary messengers involved in quorum sensing (QS) and c-di-GMP networks (diguanylate cyclase systems, DGC). In this review, we focus on the role of c-di-GMP during biofilm formation. We describe TCS and QS signal cascades regulated by c-di-GMP in response to changes in the external environment. We present a complex signaling network dynamically changing during the transition of P. aeruginosa from the free-living to sessile mode of growth.
Coronary Microcirculation and the No-reflow Phenomenon
Authors: Oikonomou Evangelos , Mourouzis Konstantinos , Vogiatzi Georgia , Siasos Gerasimos , Deftereos Spyridon , Papaioannou Spyridon , Latsios George , Tsalamandris Sotiris , Tousoulis Dimitris
Published: September 2018

The no-reflow phenomenon refers to the post-percutaneous coronary intervention condition in which,
despite re-establishing epicardial coronary vessel patency, the flow to the previously ischemic myocardium is
markedly reduced. When it does occur, it attenuates the beneficial effect of reperfusion therapy and substantial
regions of the myocardium fail to receive adequate perfusion. The pathophysiology of this phenomenon is not
completely understood. The possible mechanisms could be related to alterations in the microvascular circulation.
Various mechanisms such as activation of inflammatory pathways, vascular damage and hemorrhage, leukocyte
infiltration, and cellular edema may be responsible. As the no-reflow phenomenon is associated with adverse
clinical consequences, it is of great importance to identify exact responsible mechanisms and apply effective
preventive and therapeutic strategies. In this review, we describe an updated overview of the pathophysiological
mechanisms and the current preventive tools for no-reflow as well as therapeutic interventions in order to improve
coronary blood flow and consequently the prognosis for these patients.
The Value of Biomarkers in Optimizing the Use of Immuno-oncologic Therapy
Authors: Ferreira Carlos G. , Nicolini Andrea , Dalurzo Liliana , Stefani Stephen , Teich Vanessa , Leighl Natasha
Published: September 2018

The development of therapies that restore or activate the host immune response – the socalled
“immuno-oncologic” therapy – has improved the survival of some cancer patients harboring
specific tumor types. These drugs, however, are very expensive which has greatly limited their use and
consequently reduced the number of patients who could likely benefit. Not to mention, the proportion
of patients who display a clinical benefit from therapy is limited. Thus, from a clinical and health economics
perspective, there is a pressing need to identify and treat those patients for whom a given immuno-
oncologic therapy is most likely to be beneficial. At this end, the identification, validation and
use of biomarkers emerge as an important therapeutic tool. Here, we briefly review the state of immunologic
biomarker development and utilization and make suggestions for interested clinicians, health
policy makers and other stakeholders to prepare for the broader use of biomarkers associated with
immuno-oncologic therapy in routine practice. The biomarker field is clearly in its earliest stages and
there is no doubt that continued research will identify new biomarkers with valuable clinical indications.
Of course, the clinical utility of a biomarker must consider patient preferences and perspectives.
In addition, health economic analyses are crucial to better define the value of immunotherapy based on
precision medicine strategies and promote value-based pricing.
Advances in BPA-induced Oxidative Stress and Related Effects and Mechanisms in Liver, 1991-2017
Authors: Zhang Xun , Liu Rutao
Published: September 2018

Bisphenol A (BPA) is a widely spreading environmental endocrine disruptor . Its characteristics,
including small doses and frequent contact, make it easy to enter human body through drinking
water, food, air and other pathways, leading to tumors, infertility, and liver damage. The present review
summarizes the underlying mechanism of oxidative stress and its related effects induced by BPA
in the liver. The progress of the mechanism for oxidative stress induced by BPA is summarized, including
mitochondrial dysfunction, lipid peroxidation and inflammation reaction, liver dyslipidemia,
apoptosis, and cell death mechanism. In the future, it is necessary to elucidate the molecular mechanisms
and timing of oxidative stress to clarify the effects on different exposures to different genders
and growth stages. Besides, studying the toxic effects on BPA surrogates, BPA metabolites and BPA
combined with other pollutants in the environment is beneficial to clarify the environmental and human
health effects of BPA and provide technical reference for the development of practical control
measures.
In Vitro and In Vivo Antimetastatic Effects of ZSTK474 on Prostate Cancer DU145 Cells
Authors: Liu Jie , Tan Xiao , Zhao Wennan , Liu Jing , Xing Xiaoxue , Fan Guanwei , Zhang Ping , Zhang Zhe , Zhong Yuxu , Kong Dexin
Published: September 2018

Background:

The lethality of prostate cancer is mainly due to metastasis. Inhibition of
metastasis is expected to be a promising approach for prostate cancer therapy. Phosphatidylinositol
3-kinase (PI3K)/Akt pathway is reported to be closely involved in cell growth, migration, etc.

Objective:

The study investigated the antimetastatic activities of pan-PI3K inhibitor ZSTK474 on
DU145 cells.

Methods:

1. The In vitro effect of ZSTK474 on the migration, invasion and adhesion of DU145
cells was determined with Transwell migration assay and wound healing assay, Tranwell invasion
assay and adhesion assay, respectively. 2. In vitro effect of ZSTK474 on the signal proteins in
DU145 cells was determined with Western blot analysis and ELISA. 3. Moreover, the In vivo antimetastatic
effect of ZSTK474 was evaluated with MicroCT and histology analysis.

Results:

ZSTK474 potently attenuated the capability of migration, invasion and adhesion of DU145
cells, negatively regulated Girdin, Integrinβ1 and matrix metalloproteinases (MMPs). In addition,
the expression of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor
(VEGF), which are known to be related to angiogenesis and metastasis, was also inhibited. Oral
administration of ZSTK474 (200 mg/kg) ameliorated in vivo bone metastasis of DU145 cells, with
improved bone structure and bone mineral density (BMD). Tissue staining indicated a reduction in
metastatic DU145 cells and osteoclasts in the bones of ZSTK474-treated mice, compared with the
non-treated group.

Conclusion:

Our result demonstrated the antimetastatic activity of ZSTK474 on prostate cancer
DU145 cells, suggesting the potential application in prostate cancer patients.
Involvement of Intracellular pH in Vascular Insulin Resistance
Authors: Ramírez Marco A. , Beltrán Ana R. , Araya Jorge E. , Cornejo Marcelo , Toledo Fernando , Fuentes Gonzalo , Sobrevia Luis
Published: September 2018

The maintenance of the pH homeostasis is maintained by several mechanisms including the efflux of protons (H+) via membrane transporters expressed in almost all mammalian cells. Along these membrane transporters the sodium/H+ exchangers (NHEs), mainly NHE isoform 1 (NHE1), plays a key role in this phenomenon. NHE1 is under modulation by several environmental conditions (e.g. hyperglycaemia, protein kinase C activity) as well as hormones, including insulin. NHE1 activation causes intracellular alkalization in human endothelial cells leading to activation of the endothelial Nitric Oxide Synthase (eNOS) to generate NO. Intracellular alkalization is a phenomenon that also results in upregulation of the glucose transporter GLUT4 in cells that are responsive to insulin. A reduction in the removal of the extracellular D-glucose is seen in states of insulin resistance, such as in diabetes mellitus and obesity. Since insulin is a potent activator of eNOS in human endothelium, therefore causing vasodilation, and its vascular effect is reduced in insulin resistance it is likely that a defective signal to activate NHE1 in insulin target cells is expected. This phenomenon results in lower redistribution and activation of GLUT4 leading to reduced uptake of D-glucose and hyperglycaemia. The general concept of a role for NHE1, and perhaps other NHEs isoforms, in insulin resistance in the human vasculature is proposed.
Cancer Cell Metabolism Featuring Nrf2
Authors: Chatterjee Payal , Yadav Mukesh , Chauhan Namrata , Huang Ying , Luo Yun
Published: September 2018

Although the major role of Nrf2 has long been established as a transcription factor for
providing cellular protection against oxidative stress, multiple pieces of research and reviews now
claim exactly the opposite. The dilemma - “to activate or inhibit” the protein requires an immediate
answer, which evidently links cellular metabolism to the causes and purpose of cancer. Profusely
growing cancerous cells have prolific energy requirements, which can only be fulfilled by modulating
cellular metabolism. This review highlights the cause and effect of Nrf2 modulation in cancer that in
turn channelize cellular metabolism, thereby fulfilling the energy requirements of cancer cells. The
present work also highlights the purpose of genetic mutations in Nrf2, in relation to cellular metabolism
in cancer cells, thus pointing out a newer approach where parallel mutations may be the key factor
to decide whether to activate or inhibit Nrf2.
In silicoAnalysis of L-Glutaminase from Extremophiles
Authors: Devi Sarita , Savitri  , Raj Tilak , Sharma Nikhil , Azmi Wamik
Published: September 2018

Background:

L-glutaminase enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. Protein L-glutaminase, which converts amino acid glutamine to a glutamate residue, is useful as antileukemic agent, antiretroviral agent and a new food-processing enzyme.

Objective:

The sequences representing L-glutaminase from extremophiles were analyzed for different physico-chemical properties and to relate these observed differences to their extremophilic properties, phylogenetic tree construction and the evolutionary relationship among them.

Methods:

In this work, in silico analysis of amino acid sequences of extremophilic (thermophile, halophile and psychrophiles) proteins has been done. The physiochemical properties of these four groups of proteins for L-glutaminase also differ in number of amino acids, aliphatic index and grand average of hydropathicity (GRAVY).

Result:

The GRAVY was found to be significantly high in thermophilic (2.29 fold) and psychrophilic bacteria (3.3 fold) as compare to mesophilic bacteria. The amino acid Cys (C) was found to be statistically significant in mesophilic bacteria (approximately or more than 3 fold) as compared to the abundance of this amino acid in extremophilic bacteria.

Conclusion:

Multiple sequence alignment revealed the domain/motif for glutaminase that consists of Ser-74, Lys-77, Asn-126, Lys-268, and Ser-269, which is highly conserved in all microorganisms.
Association of PPARG Gene Polymorphisms Pro12Ala with Type 2 Diabetes Mellitus: A Meta-analysis
Authors: Li Junyan , Niu Xiaohong , Li JianBo , Wang Qingzhong
Published: September 2018

Background:

Previous studies suggested that the single nucleotide polymorphisms of Pro12Ala located within the PPARG gene were significantly associated with the T2DM. Recently, the genetic studies on Pro12Ala were conducted in the different ethnic groups and the results of each study were shown to be inconsistent. Moreover, the systematic review has not been updated since 2000.

Objective:

To further validate the risk of Pro12Ala for T2DM disease based on the genetic data.

Methods:

The genetic studies on the Pro12Ala in the T2DM were searched in the PubMed and PMC database from January 2000 to October 2017. The meta-analysis was conducted with the CMA software.

Results:

The meta-analysis collected 14 studies including 20702 cases and 36227 controls. The combined analysis of all studies found that Pro12Ala was shown to be significantly associated with T2DM and the Ala allele played the increasing risks for the disease. Nevertheless, publication bias was detected in the combined analysis. The subgroup analysis indicated that Pro12Ala was found to be significant in the Caucasian and Chinese population. There was no heterogeneity and publication bias in these two groups.

Conclusion:

The meta-analysis confirmed the evidence that the Pro12Ala was the susceptible variant for the decreasing risks for the T2DM
A Mini-Review: The Therapeutic Potential of Bone Marrow Mesenchymal Stem Cells and Relevant Signaling Cascades
Authors: Yang Wen , Ma Bo
Published: September 2018

Bone marrow mesenchymal stem cells (BMSCs) characterized multi-directional differentiation, low immunogenicity and high portability, serve as ideal “seed cells” in ophthalmological disease therapy. Therefore, in this mini-review, we examined the recent literature concerning the potential application of BMSCs for the treatment of ophthalmological disease, that includes: the cellular activity of BMSCs transplantation, migration and homing, as well as the immuno-modulatory and antiinflammatory effects of BMSCs and signaling involved. Each aspect is complementary to the others and together these aspects promoted further understanding of the potential use of BMSCs in treating ophthalmological diseases.
Pinocembrin-Enriched Fractions of Elytranthe parasitica (L.) Danser Modulates Apoptotic and MAPK Cellular Signaling in HepG2 Cells
Authors: Kumar Nimmy , Shrungeswara Akhila H. , Mallik Sanchari B. , Biswas Subhankar , Mathew Jesil , Nandakumar Krishnadas , Mathew Jessy , Lobo Richard
Published: September 2018

Background:

Hepatocellular carcinoma (HCC) is the fifth leading cause of cáncer mortality. Elytranthe
parasitica (L.) Danser (EP), a hemiparasitic plant (Loranthaceae) has potent anti-cancer properties.

Objective:

In the study, we investigated the effect of EP fractions on the expression of apoptosis and mitogenactivated
protein kinase (MAPK) markers deregulated in HCC. Bioactivity fractionation was performed to isolate the
phytochemical(s) exerting anti-tumor activity in HepG2 cells.

Method:

Anti-proliferative, clonogenic and anti-metastatic effects of EP fractions were examined in hepatocellular
carcinoma cell line, HepG2 by Sulphorhodamine B, colony formation and scratch wound assays respectively in
hepatocellular cell line, HepG2. The effects of EP fractions on key markers of apoptosis and MAPK signaling pathways
were explored.

Key findings: EP bioactive fractions showed significant anti-tumor potential, reduced clonogenicity and considerably
inhibited cell migration in HepG2 cells in vitro. The fractions augmented annexin V binding and induced apoptosis
by causing cell cycle arrest at G2/M and S phase checkpoints. The fractions increased expression levels of p53, bad,
cleaved PARP (Poly ADP ribose polymerase) and cleaved Caspase-3. Expression levels of phosphorylated ERK1/2
(Extracellular signal-regulated kinase) were downregulated. Pinocembrin-7-O-ß-D-glucoside and chrysin were isolated
and characterized for the first time from Elytranthe parasitica (L.) Danser.

Conclusion:

Our findings reveal that EP fractions induced cell cycle arrest and triggered apoptosis in HepG2 cells by
upregulating apoptosis and deactivating MAPK pathway. It signifies that pinocembrin glycoside and chrysin are
bioactive phytochemicals contributing to the potent anti-hepatocarcinoma effects on HepG2 cells. Hence, bioactive
EP fractions could be used as a therapeutic agent for effective HCC therapy.
Time and Size-dependent Biogenically Synthesized Nanoparticles Using Fungus Fusarium Oxysporum: A Review on their Preparation, Characterization and Biological Activities
Authors: Gupta Khushbu , Chundawat Tejpal Singh
Published: September 2018

In recent time, green synthesis of Metal Nanoparticles (MNPs) is the latest developing
technology and received exceptional interest because it is simple, eco-friendly, pollutant-free, nontoxic,
and a low-cost approach. Green route of biogenic synthesis of metal nanoparticles via microbes
(bacteria, fungi, virus, yeast, algae etc.) has the potential to deliver clean manufacturing technology.
Fungi are in the great use for the synthesis of nanoparticles and are more advantageous as
compared with other microorganisms in several ways. Fungi grow in the form of a group of mycelia,
which helps them to withstand flow pressure and agitation and various other conditions to which microbes
are subjected to in a bioreactor, used for large-scale production. This review has its major focus
on fungus Fusarium oxysporum, which is capable of synthesizing a large number of different
types of nanoparticles such as titanium, magnesium, platinum, silver, gold, zirconium, and strontium,
titania and silica oxide and many more. Biogenically synthesized nanoparticles are characterized by
different techniques and exhibited biological activity. The fungi with metabolic capabilities can effectively
synthesize a large number of nanoparticles both extracellularly and intracellularly. The biologically
synthesized nanoparticles have wide ranges of applications especially in agricultural and
medicinal industries.
DETERMINING HOUSING AFFORDABILITY FOR YOUNG PROFESSIONALS IN KLANG VALLEY, MALAYSIA: RESIDUAL INCOME APPROACH
Authors: Sohaimi Nor Suzylah , Abdullah Alias , Shuid Syafiee
Published: September 2018

Underprivileged young professionals in housing affordability are prone to an adverse effect on their well-being. This article empirically examines housing affordability among young professionals aged between 25 and 35 years old who work or live in Klang Valley. Young professionals in this paper refer to young graduates with at least a Bachelor’s degree and are registered to professional institutions such as the Institution of Engineers Malaysia (IEM), Malaysian Institute of Architects (MIA), Malaysian Institute of Planners (MIP), and Royal Institution of Surveyor Malaysia (RISM). The aim of this study is to measure housing affordability based on residual income approach and to identify the attribute that affects young professionals’ housing affordability. Adequacy of household income for monthly mortgage or rent as well as other non-housing goods is reflecting for housing affordability. Attributes namely occupation, the presence of children, household expenditure, transportation cost, vehicle instalment, education loan, and household income are analysed by using binary logistic regression. 264 respondents who are either a homeowner, tenant, or parental home resident were selected by using simple random sampling. The survey data were collected through the professional institutions respectively. The study found that only presence of children, occupation of urban planner and education loan III (not taking a loan) were insignificant to the model.
FACTOR ANALYSIS ON HEDONIC PRICING MODEL ON OPEN SPACE AFFECTING THE HOUSING PRICE IN MELAKA AND SEREMBAN
Authors: Asmawi M. Zainora , Abdul Mohit Mohammad , Mohd Noor Norzailawati , Abdullah Alias , Paiman Tuminah
Published: September 2018

Open spaces near residential area often labelled as development constraint since each residential development must provide 10 percent of open space from the total acreage according to Malaysia planning guidelines. Kuala Lumpur has noticeable lost in open space in residential area and this issue might happen with other neighbourhood states such as Negeri Sembilan and Melaka. Therefore, the purpose of this study is to find the resident perspective on the importance of open space while purchasing their housing property. As such, the aim of the research is to study and examine the characteristics of relationship between public openspaces and residential property value using GIS-Hedonic pricing modelling in the selected residential area in Seremban and Melaka. To find the gist of this study, factor analysis has been used to sum the hedonic pricing model output. Seremban and Melaka respondents have chosen the Importance of the House attributes in influencing the house price and Importance of open space following factors in influencing the house price. The research examined the relationship between the open space and house price at selected area in Seremban and Ayer Keroh. As found in the literature reviews, it validates that the relationship established in a positive pattern.
GEN Z’S ACTIVITIES AND NEEDS FOR URBAN RECREATIONAL PARKS
Authors: Ghani Nurfaezah , Mansor Mazlina , Zakariya Khalilah
Published: September 2018

A public recreational park for youth is important in promoting leisure activities for their health. Engagement with outdoor activity contributes to healthy growth development physically, mentally and socially. Youth prefers places that offer favourable facilities where they can express themselves with presence friends. The study focuses on Generation Z youth (Gen Z), who are born between the mid of the 1990s through the late 2000s. The study investigates Gen Z activities and needs of recreational parks in Kuala Lumpur. The study obtained 564 respondents who lived in five strategic zones in Kuala Lumpur. Their responses were statistically analyzed using the SPSS. Results showed that the Gen Z frequented recreational parks near their homes. Titiwangsa Lake Garden, KLCC Park and Kepong Metropolitan Park are among their place preference. A recreational park for them should have more natural attributes and meet their active lifestyle. The places encourage them to have an active engagement and positive socialization with others.
THE RELATIONSHIP BETWEEN LEARNING SPACE ATTRIBUTES WITH STUDENTS' SATISFACTION AND PERCEIVED PERFORMANCE
Authors: Abdul Munir Fadhlizil Fariz , Abdul Tharim Asniza Hamimi , Mohd Thuraiya , Said Suzana
Published: September 2018

The shift in the learning patterns of the current generation motivates the changes in the setting of learning spaces. This research objective is to examine the association between Learning Space attributes with student satisfaction and perceived performance. A survey was conducted in Universiti Teknologi MARA (UiTM), Perak Branch, Seri Iskandar Campus, Malaysia. A questionnaire was administered and collected from 410 students, where respondents were asked to select their preferences based on a five-point Likert scale of agreement and satisfaction. The analysis was conducted using PLS-SEM: Smart-PLS Version 3.2 to examine the measurement and structural model of the research. Results indicated that there is a significant relationship between Learning Space attributes with student satisfaction and perceived performance. The overall findings of this research show that the research variables successfully predicted the model.
CLASSIFICATIONS OF CLASSICAL MALAY ARISTOCRATIC ARCHITECTURE: IDENTIFYING GENERIC AND VARIANT FORMS
Authors: Raja Abdul Kadir Tengku Anis Qarihah , Jahn Kassim Puteri Shireen , Abdul Majid Noor Hanita , Kamaruddin Zumahiran
Published: September 2018

The paper reports on a basic classification based on formal and morphological similarities of large vernacular buildings across the Malay region, based on their frontages; with the aim of developing a universal regional language and set of rules of local architecture for urban and multi-storeys typologies. Generally, seen as idiosyncratic and individualistic, Malay regional palaces and mansions across different states and regions under former Sultanates, exhibit different vocabularies, yet have underlying similarities. While form and architecture may arise from the local technology and construction methods of the era, aesthetic expressions of these palaces recall formal archetypes which can be described, and characterised, regardless of location. Focusing on palaces in Malaysia and East Sumatran region from the late 1800s onwards, recurring forms of a Malay-Classical language are observed and classified into generic morphologies of frontages. The aim is towards formal taxonomy that can represent a more inclusive architectural identity of the region, rather than identities based on nations. By defining the ‘generic’ and the ‘variant’, significant palaces across the Malay region are discussed and positioned within a classification based on a range of generic archetypes. Variants include cases which have absorbed external influences yet retain the essences of local form, while some examples, refer to elements that have modernised been yet represent the last offshoot or branch of the same region. To identify generic rules and frameworks of design, the regional roots of form, including frontages, for public buildings is crucial for urbanscape and the urgency of developing guidelines and a set of compositional rules and language of urban architecture derived from the essences of tradition and past forms.
Perspektif Burnout Pada Manajer Proyek Di Indonesia
Authors: Santoso Prasidananto Nur , Hartono Budi
Published: September 2018

Burnout is a psychological syndrome caused by acute stress that characterized by emotional exhaustion and disability to sustain the work productivity. In the project management context, burnout can reduce productivity and increase the idle work. This research aims to examine the concept of burnout in the context of Indonesian project managers. This research was done by the cross-section survey with the questionnaire based on the job demands-resources (JD-R) concept adopted from some earlier research. The response rate of 27.22 percent obtained from 78 project manager in Indonesia with the results indicate that job resources affect job demands, the job demands affect burnout which affects job satisfaction at least.
Analisa Dampak Lingkungan Pada Instalasi Pengolahan Air Minum (IPAM) Dengan Metode Life Cycle Assessment (LCA)
Authors: Irawati Desrina Yusi , Andrian David
Published: September 2018

Babat Drinking Water Treatment Plant (IPAM Babat) is one of the clean water facilities for Lamongan community. The process of clean water requires an appropriate processing. This process requires chemicals and energy that it will adverse effects to the environment. Life Cycle Assessment (LCA) is one of the environmental effects analyze methods for clean water process. The four phases of LCA are Goal And Scope Definition, Life Cycle Inventory, Life Cycle Impact Assessment, and Interpretation. The environmental impacts of the LCA method of processing are divided into three broad categories of impacts, namely the categories of human health, ecosystem quality, and resources. The result of LCA analyzed shows that electrical energy utilization product an environment impact significantly. This impact has consequences on the resource category (fossil fuels) and human health (climate change) due to CO2 combustion. The largest electric consumption is used for tools of pumping water due to the distant length intake and IPAM. The solution for reduced the electric consumption is using the equipment efficiency and water flow system by the power of gravity.
Pengobatan Malaria Kombinasi Artemisinin (ACT) di Provinsi Papua Barat Tahun 2013
Authors: Kinansi Revi Rosavika , Mayasari Rika , Pratamawati Diana Andriyani
Published: September 2018

Malaria is still a disease with highest incidence rate in Indonesias. Based on Riskesdas 2013, the prevalence of malaria in West Papua was generally increasing. This study aimed to find the correlation of  type of malaria found in blood examination and distribution status of ACT.  Samples of data obtained by stratified random sampling from 1490 people who had suffered from malaria in West Papua. Data analysis using univariate descriptive and correlation analysis The result showed that the most common type of malaria was tertiana malaria caused by Plasmodium vivax (51%). Early detection performed within the first 24 hours when the patient is suffering from fever can be used as the basis for a policy that early detection can reduce malaria morbidity. It can be concluded ACT suitable for any type of malaria. The concistency of provision of ACT can be implemented by increasing public awareness of taking prophylactic. In addition the ideal combination antimalarial drugs be  able to heal in a short time and if the patients performs the compliance of taking the drug, it will not be antimalarial resistance.
Daya Saing Kawin Nyamuk Jantan Steril (Culex quinquefasciatus) Skala Laboratorium: Studi Awal Penggunaan Teknik Serangga Mandul dalam Pengendalian Vektor Filariasis Limfatik di Kota Pekalongan
Authors: Ramadhani Tri , Hadi Upik Kusuma , Soviana Susi , Irawati Zubaidah , Sunaryo Sunaryo
Published: September 2018

Culex quinquefasciatus is the main vector of limfatic filariasis in Pekalongan City. Sterile Insect Tehnique could be an alternative vector control efforts to eliminate filariasis. The success of this technique is depend on the ability of laboratory-reared sterile males with the wild-type females. Indicator of SIT Aplication is determined by the value of the mating competitiveness and sterility to Culex quinquefasciatus (Diptera:Culicidae). The design of the research is an experimental. Gamma irradiation on the pupae (age . 15 hours) with the  doses of 0 Gy, 60 Gy, 65 Gy,70 Gy, 75 Gy and 80 Gy in BATAN Jakarta.  Male mosquitoes which emerged from the pupa then matting with a normal female. This research observed the mean  of females laying eggs ,fecundity, fertility and  mating competitiveness. This experimental research was conducted in the laboratory and the data were analyzed by ANOVA.The result showed that irradiation at the trial doses had an effect on fertility of Culex quinquefasciatus, but not  had significant effect on  fecundity and mating competitiveness . A dose of 70 Gy is the optimum dose with a fertility rate of 1.8% (sterility 98.2%) and C indexs 0,568 can be recommended for futher  semi field assays. The number of sterile males were six times compared with the wild population to increase the chances of  mating with wild-type females.
Parameter Entomologi pada Daerah Endemis Demam Berdarah Dengue Tinggi dan Rendah di Jawa Tengah (Studi di Kabupaten Kudus dan Wonosobo)
Authors: Ikawati Bina , Wahyudi Bondan Fajar , Astuti Novia Tri , Sunaryo Sunaryo
Published: September 2018

Kudus district is a district with high DHF cases in  Central Java in 2013 (IR=57.50). Wonosobo District is new area with low DHF cases (IR=11.92). Aedes aegypti is the main vector of DHF in both. The purpose of this study was to determine the difference of entomological parameter in high and low DHF endemic area. This research was continued analysis of entomologycal data from study of The Resistance Map of Aedes aegypti (Linn)  Agains Cypermethrin 0,05%, Malathion 0,8% and Temephos inn Purworejo, Kebumen, Pekalongan, Demak, Wonosobo, Cilacap, Kudus, Klaten, Banjarnegara  at 2014, that use cross sectional design. The results showed that HI, CI, BI and  PI  in Kudus (40,67%,21,40%, 233,67 and 113,67%), higher than in Wonosobo (14,33%, 10,93%, 15,33 dan 38,33%). In all location bathing tub were the potential breeding places of Ae. aegypti. In Kudus, Breeding Preference Ratio (BPR) in barrel and water tank for “wudhu” had the highest as much as 4.03. In Wonosobo the highest BPR was in jar as much as 9.15. Multivariat analysis showed that in Kudus container covers were most closely correlated to the presence of  Ae. aegypti larvae, while in Wonosobo illumination around containers is the main factor.
Re-Transmission Assessment Survey Filariasis Pasca Pengobatan Massal di Kabupaten Agam, Provinsi Sumatera Barat Tahun 2016
Authors: Santoso Santoso , Cahyaningrum Sri
Published: September 2018

Agam District finished the repetition of Filariasis treatment for 2 years, so Agam must be conducting the Re-TAS. Re-TAS was conducted on elementary school students grade 1 and 2 in the district of Agam. Survey design using the school cluster. The number of schools selected were 40 schools. Selection of the sample schools were calculated using sample survey builder (SSB). All students grades 1 and 2 in selected schools were examined using Brugia Rapid test to assess the presence of specific antibodies against Brugia malayi and B. timori worms. The  number of students who registered as many as 1,999 children, while being examined by RDT as many as 1,717. A total of 282 students were absent during the examination or refused to be examined.Test results showed that 3 positive, 1694 negative, 20 invalid and 3 samples were excluded. The number of samples taken into account to assess the transmission of filariasis as many as 1,697, which is only positive and negative samples. The survey found that the minimum sample was adequate and the number of positive children under the cut off point, so Agam passed TAS 1.
Software Quality Assurance A Study Based on Pakistan’s Software Industry
Authors: Iftikhar Asim , Ali Sheikh Muhammad
Published: September 2018

This paper investigates the role of quality management practices in software industry of Pakistan. We present a comparison between the more-experienced and less-experienced firms with respect to the critical factors of quality management. The critical factors of quality management practices in the software industry are first identified from the literature survey and validated through an empirical study. The study attempts to probe the influence of “age of quality” and “use of software” over software quality management practices and programs. The results of the study shows that the ‘age of quality” and “use of software” have partial influence over the software quality management.
Use of Technology Acceptance Model for Turnitin®
Authors: Alam Dr. Abu Turab
Published: September 2018

A useful Information System is difficult to conceive and develop. Research on technology has revealed that end-user likes or dislikes may matter towards the success or failure of information system (IS). A highly complicated system in which developers have put lots of development efforts may fail if the end-user dislikes it after its initial installation. In software engineering literature it is claimed that system rejection is mostly caused by not meeting the non-functional requirements. In this paper, a study is being done on ‘turnitin®’ as technology and its acceptance to a group of students in order to find out confirmation of result as claimed by TAM while it is a post implementation research activity for technology acceptance.
New Exact Solutions of Steady Plane Flows of an In Compressible Fluid of Variable Viscosity
Authors: Younus Sobia
Published: September 2018

Some new exact solutions to the equations governing the steady plane motion of an in compressible fluid of variable viscosity for the chosen form of the vorticity distribution are determined by using transformation technique. In this case the vorticity distribution is proportional to the stream function perturbed by the product of a uniform stream and an exponential stream
Do local and global macroeconomic variables help forecast volatility of Pakistani stock market?
Authors: Iqbal Javed , Javed Mariam
Published: September 2018

Emerging markets are characterized by higher volatility and higher associated returns as compared to developed markets. The excessive volatility in emerging markets is often considered a result of inherent instability and unpredictability of country’s political, institutional and macroeconomic environment. Increasing globalization and integration of financial markets imply that volatility of emerging markets may also be affected by global macroeconomic and business conditions. We investigate this issue for an emerging market namely Pakistan. An important objective of this research is to provide empirical evidence on whether local and global macroeconomic variables help forecast volatility of this market over and above the GARCH models which predict volatility on the basis of past shocks and past accumulated variance. Using monthly data over the post liberalization period from early 1990 to 2010 we show that global variables have higher explanatory power to affect Pakistani stock market volatility compared to the global information variables.
Relationship Between Faculty’s Self Actualization and Student’s Faculty Evaluation: A Case-study
Authors: Ali Khan MoinUddin
Published: September 2018

The objective of this research is to find, if there exists some correlation between self actualization scores of faculty with student’s faculty’s evaluation scores.. The study is based upon the instrument that measures self actualization score, a questionnaire designed by Dr. Richard Boyum and the standard student’s feedback proforma. The faculty’s self actualization and student’s evaluation scores are compared using regression and correlation analysis, a scatter dot diagram is also used for the same purpose. The result concludes, that no significant correlation exists between faculty’s self actualization level and student’s faculty’s evaluation. Whereas separate analysis of surveys concludes that senior faculty (Senior Fellows and Head of Academic departments) are higher self actualized than younger faculty and students. The study recommends that faculty evaluation should be summation of student’s, peer, self and management’s evaluation. Also, while hiring a new faculty, self actualization level should also be a criteria for selection. The young faculty level of self actualization can improve with support and better environment.
The Conditional Relationship between Risk and Return: Evidence from an Emerging Market
Authors: Azher Sara
Published: September 2018

This paper examine whether the conditional relationship between beta
and return proposed by Pettengill et al. (1995) exist in an emerging
stock market namely Pakistan. We applied this approach to Karachi
Stock Exchange (KSE-100) returns data over the period of 1992-2008,
and found that there is a flat unconditional relationship between beta
and return which is consistent with previous research. And when we
split our sample into up market and down market return months, our
result supported the conditional relationship.
Exploring University Students Perceptions about Using Mobile Phone as Learning Aid
Authors: Naqvi Rabab , Bhamani Shelina
Published: September 2018

This study examined the perception of students’ in using mobile
phones as a learning aid within universities in Karachi. The prime
objective of the study was to evaluate the student’s readiness and
acceptance in incorporating m-learning in their learning process.
For this purpose data was collected from different universities in
Karachi aged between 22-40 years with a sample size of N=204. To
test the data Mobile learning survey was used, consisted of 16
items with a Likert response scale providing ranges from 1-5 from
strongly disagree to strongly agree, followed by asking their ability
to use their phones for educational purposed and later captivating
their idea of mobile phones integration into their classrooms. Results
of the study showed that students’ spent plenty of time on their cell
phones and they use it for a variety of applications. The results also
indicated that they knew almost all of its function and were using
them in their daily lives. They were already using their mobile phones
for retrieval of information and according to them it had removed
learning barriers. However students’ were not sure if m-learning
should be incorporated into their classrooms
Requirement Correctness Problems and Strategies for Web Applications
Authors: Naeem M. Athar , Waheed Usman , Raza Syed Furqan Ali
Published: September 2018

Correctness means that application planned tasks as defined by its specification. This
research paper conversing that if poor requirements are not executed in the application
there is some difficult existing in the application. Some other resembling problems like
ambiguous requirements and inappropriate constraints also exist in the application. For
these problems some solution techniques provided like documentation, verifying
techniques of requirements, and use case of completeness validation.