bluuebunny/crossref_metadata_2025 huggingface dataset:
An improved method for EMD modal aliasing effect
Authors: Feng Shao-Wei , Chai Kai
Published: November 2020

In order to eliminate the modal aliasing effect of the empirical modal decomposition (EMD) caused by signal interruption (singular event, cycling wave, local impact signal) or the interaction of each component, two elimination methods are proposed, namely, high frequency harmonic method and mask signal method. Firstly, two causes of EMD mode aliasing are analyzed: one is the local oscillation in the signal; the other is the amplitude-frequency relation of the signal. Secondly, the local impact mode aliasing is solved by the high frequency harmonic method. Finally, mask signal method is used to eliminate modal aliasing of similar frequencies. The simulation results show that the two methods of eliminating EMD modal aliasing, which are collected high frequency harmonic method and mask signal method, can quickly and effectively curb the modal aliasing phenomenon on the basis of ensuring the adaptive characteristics of EMD, and provide a novel method to expand the real-time online application of EMD.
Modeling and simulation on engraving process of projectile rotating band based on two-phase flow interior ballistic
Authors: Wang Zhen , Wang Liqun , Yang Guolai
Published: November 2020

This paper explores the transient mechanics mechanism of the projectile with double rotating bands engraving into the rifle and the propellant gas pressure distribution law during the rotating band engraving process. Previous studies usually ignored the coupling of projectile, artillery, and gunpowder parameters during the engraving process. To end this, taking a large-caliber artillery system as the research object, a projectile-barrel-charge coupled finite element model is established based on the two-phase flow interior ballistic theory and the finite element method, followed by numerical simulation. Through the comparison with experimental results, such a modeling method is proved to be effective.
Institutionalising wastewater surveillance systems to minimise the impact of COVID-19: cases of Indonesia, Japan and Viet Nam
Authors: Takeda T. , Kitajima M. , Huong N. T. T. , Setiyawan A. S. , Setiadi T. , Hung D. T. , Haramoto E.
Published: November 2020

This mini review describes the current status and challenges regarding institutionalisation of wastewater surveillance systems against COVID-19. Monitoring SARS-CoV-2 in wastewater has been proposed to be a potential tool to understand the actual prevalence of COVID-19 in the community, and it could be an effective approach to monitor the trend during the COVID-19 pandemic. However, challenges to institutionalise wastewater surveillance systems are still abundant and unfolding at a rapid rate given that the international understanding regarding the scientific knowledge and socio-political impacts of COVID-19 are in the developing stages. To better understand the existing challenges and bottlenecks, a comparative study between Japan, Viet Nam, and Indonesia was carried out in the present study. Through gaining a better understanding of common issues as well as issues specific to each country, we hope to contribute to building a robust multistakeholder system to monitor SARS-CoV-2 in wastewater as an effective disease surveillance system for COVID-19.
Analysis on differences in Canada and China's official attitude and perception on their minority nationalities
Authors: Song Dennis
Published: November 2020

The government’s perceptions and attitudes of their ethnic minorities are in close relation with the ethnic minorities’ welfare policies, and also affect the public’s perception of ethnic minorities. Therefore a government’s definition and attitudes are crucial to maintaining national stability. For instance, Canada is a multi-nation state, comprising multiple ethnic groups in one country, with the two most influential as the French-Canadians and the English-Canadians. French and English Canadians are majority ethnic groups while there are many other minority ethnic groups such as the First Nations. The People’s Republic of China is also a multi-nation state, although the biggest ethnic group, the Hans, comprise 98% of the entire population.11 Although all nations have their own cultural cognition - common descent, history, culture, and language - both Canada and China have their own unique definition for their minority nations: Canada’s minority nations are the Aboriginal People of Canada 22, and China’s minority nations are the 55 officially recognized ethnic groups other than the Han people. This essay aims to compare the official perceptions and attitudes of ethnic minorities in China and Canada, hoping to clarify the relationship between ethnic minorities and mainstream ethnic groups, and help the general public to understand them, hence promoting harmonious societal development.
Pharmaceutical and Biomedical Applications of Green Synthesized Metal and Metal Oxide Nanoparticles
Authors: Zafar Nabila , Madni Ahmed , Khalid Ayesha , Khan Taous , Kousar Rozina , Naz Syeda Sohaila , Wahid Fazli
Published: November 2020

Background:

Due to the rapid growth in life threatening diseases such as cancer, diabetes, chronic
wound and HIV/AIDS along with rise of side effects of the current treatments, world is now focusing to utilize
new treatment options. Currently, the development of green nanotechnology field seems as a potential alternate
for diseases diagnosis and treatment by preparation of various sizes and shapes of nanomaterials.

Objective:

This review is to present the explored biological sources in synthesis of nanomaterials particularly
metal and metal oxides nanoparticles and critical review of the applications of biosynthesized nanoparticles in
pharmaceutical and biomedical fields.

Methods:

In this review, the various biological sources including bacteria, fungi, algae and plants used in synthesis
of nanomaterials and mechanism involved in preparation are elaborated. In addition, biosynthesized nanomaterials
applied as drug delivery system for anticancer, antibiotic, antidiabetic agent and functioned as potential
diagnostic, antimicrobial, anticancer and wound healing candidates are comprehensively reviewed.

Results:

The synthesized metal and metal oxides from green protocol proved to have advantages such as being
biocompatible, effective and cheap. Furthermore, the green synthesized metal and metal oxide nanoparticles
showed to possess prominent physical, chemical and biological properties that can be efficiently utilized for
pharmaceutical and biomedical applications.

Conclusion:

The information gathered in this review will provide a baseline for exploring more potential usage of
green synthesized metal and metal oxide nanomaterials for various other applications. However, a concrete understanding
of the safety of these nanomaterials is still needed to minimize the potential side effects.
A Review on Plant Flavonoids as Potential Anticancer Agents
Authors: Kapoor Bhupinder , Gulati Monica , Gupta Reena , Singh Sachin Kumar , Gupta Mukta , Nabi Arshid , Chawla Pooja A.
Published: November 2020

Flavonoids are polyphenolic compounds that are mainly derived from fruits and
vegetables and constitute an essential part of plant-derived beverages such as green tea, wine
and cocoa-based products. They have been shown to possess anticancer effects via different
mechanisms such as carcinogen inactivation, antiproliferation, cell cycle arrest, induction of
apoptosis and differentiation, inhibition of angiogenesis, anti-oxidation and reversal of
multidrug resistance or a combination of any two or more of these mechanisms. The present
review summarizes the chemistry, biosynthesis and anticancer evaluation of flavonoids in
both animal and human studies. A special emphasis has been placed on the flavonoids that are
being screened in different phases of clinical trials for chemoprotective action against various
cancers.
The Role of Metabolism in Toxicity of Polycyclic Aromatic Hydrocarbons and their Non-genotoxic Modes of Action
Authors: Vondráček Jan , Machala Miroslav
Published: November 2020

Polycyclic aromatic hydrocarbons (PAHs) represent a class of widely distributed environmental pollutants
that have been primarily studied as genotoxic compounds. Their mutagenicity/genotoxicity largely depends
on their oxidative metabolism leading to the production of dihydrodiol epoxide metabolites, as well as additional
metabolites contributing to oxidative DNA damage, such as PAH quinones. However, both parental
PAHs and their metabolites, including PAH quinones or hydroxylated PAHs, have been shown to produce various
types of non-genotoxic effects. These include e.g., activation of the aryl hydrocarbon receptor and/or additional
nuclear receptors, activation of membrane receptors, including tyrosine kinases and G-protein coupled receptors,
or activation of intracellular signaling pathways, such as mitogen-activated protein kinases, Akt kinase
and Ca2+-dependent signaling. These pathways may, together with the cellular DNA damage responses, modulate
cell proliferation, cell survival or cell-to-cell communication, thus contributing to the known carcinogenic
effects of PAHs. In the present review, we summarize some of the known non-genotoxic effects of PAHs, focusing
primarily on those that have also been shown to be modulated by PAH metabolites. Despite the limitations
of the available data, it seems evident that more attention should be paid to the discrimination between the
potential non-genotoxic effects of parental PAHs and those of their metabolites. This may provide further insight
into the mechanisms of toxicity of this large and diverse group of environmental pollutants.
Breast Cancer Resistance Protein: A Potential Therapeutic Target for Cancer
Authors: Mehendale-Munj Sonali , Sawant Shivangi
Published: November 2020

Breast Cancer Resistance Protein (BCRP) is an efflux transporter responsible for causing
multidrug resistance (MDR). It is known to expel many potent antineoplastic drugs, owing to
its efflux function. Efflux of chemotherapeutics because of BCRP develops resistance to many
drugs, leading to failure in cancer treatment. BCRP plays an important role in physiology by protecting
the organism from xenobiotics and other toxins. It is a half-transporter affiliated to the ATP-
binding cassette (ABC) superfamily of transporters, encoded by the gene ABCG2 and functions
in response to adenosine triphosphate (ATP). Regulation of BCRP expression is critically controlled
at molecular levels, which help in maintaining the balance of xenobiotics and nutrients inside
the body. Expression of BCRP can be found in brain, liver, lung cancers and acute myeloid
leukemia (AML). Moreover, it is also expressed at high levels in stem cells and many cell lines.
This frequent expression of BCRP has an impact on the treatment procedures and, if not scrutinized,
may lead to the failure of many cancer therapies.
Can Host Cell Proteins Like ACE2, ADAM17, TMPRSS2, Androgen Receptor be the Efficient Targets in SARS-CoV-2 Infection?
Authors: Gupta Vivek K. , Murthy Madhan K. , Patil Shripad
Published: November 2020

:

A novel betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
-2), which caused a large disease outbreak in Wuhan, China in December 2019, is currently spreading
across the world. Along with binding of the virus spike with the host cell receptor, fusion of the
viral envelope with host cell membranes is a critical step in establishing successful infection of
SARS-CoV-2. In this entry process, a diversity of host cell proteases and androgen receptor play a
very important role directly or indirectly. These features of SARS-CoV-2 entry contribute to its
rapid spread and severe symptoms, high fatality rates among infected patients.

:

This review is based on the latest published literature including review articles, research articles,
hypothetical manuscript, preprint articles and official documents. The literature search was made
from various published papers on physiological aspects relevant to SARS-CoV and SARS-CoV-2.

:

In this report, we focus on the role of host cell proteases (ACE2, ADAM17, TMPRSS2) and androgen
receptor (AR) in SARS-CoV-2 infection. The hypotheses put forth by us are based on the role
played by the proteases ACE2, ADAM17, TMPRSS2 and AR in SARS-CoV-2 infection, which
were deduced based on various studies. We have also summarized how these host proteins increase
the pathology and the infective ability of SARS-CoV-2 and we posit that their inhibition may be a
therapeutic option for preventing SARS-CoV-2 infection.
Fenugreek Cultivation with Emphasis on Historical Aspects and its uses in Traditional Medicine and Modern Pharmaceutical Science
Authors: Sun Wenli , Shahrajabian Mohamad Hesam , Cheng Qi
Published: November 2020

:

Fenugreek (Trigonella foenum-graecum L.) is a native plant found in the parts of Iran to the
North of India, and is presently planted also in other regions of the world. Fenugreek is considered a
notable multipurpose medicinal and traditional herb in Iran, India, and China for several centuries.
The most important components of fenugreek seeds are protein, neutral detergent fiber, gum, lipids,
moisture, ash and starch. Fenugreek seeds and leaves are anti-cholesterolemic, anti-tumor, antiinflammatory,
carminative, demulcent, deobstruent, emollient, expectorant, galactogogue, febrifuge,
laxative, hypoglycaemic, restorative, parasiticide and uterine tonic and useful in burning sensation.
Traditionally, fenugreek seeds being used worldwide are beneficial for bone and muscles, respiratory
system, gastro-intestinal system, female reproductive system, cardio-vascular system, endocrinology
and hepatic. Fenugreek helps reduce cholesterol, reduce cardiovascular risk, control diabetes, a good
consolation for sore throats, a remedy for acid reflux, constipation, colon cancer prevention, appropriate
for kidney trouble, skin infection, increase milk production, reduce menstrual discomfort, and reduce
menopause symptoms. It is also an appetite suppressant that helps in weight loss. Both modern
science and traditional medicine integration with novel technologies and discoveries will secure the
cultivation of medicinal herbs and promote sustainability in the long-term and a wide-range.
Non-steroidal Anti-inflammatory Drugs as Candidates for the Prevention or Treatment of Alzheimer’s Disease: Do they Still Have a Role?
Authors: Villarejo-Galende Alberto , González-Sánchez Marta , Blanco-Palmero Víctor A. , Llamas-Velasco Sara , Benito-León Julián
Published: November 2020

Purpose of Review:

To provide an updated analysis of the possible use of non-steroidal
anti-inflammatory drugs (NSAIDs) as treatments for Alzheimer´s disease (AD).

Recent Findings:

Neuroinflammation in AD is an active field of research, with increasing evidence
from basic and clinical studies for an involvement of innate or adaptive immune responses in the
pathophysiology of AD. Few clinical trials with anti-inflammatory drugs have been performed in the
last decade, with negative results.

Besides the information gathered from basic research, epidemiological studies have provided
conflicting findings, with most case-control or prevalence studies suggesting an inverse relationship
between NSAIDs use and AD, but divided results in prospective population-based incident
cohort studies. Clinical trials with different NSAIDs are almost unanimous in reporting an absence of
clear benefit in AD.

Conclusion:

The modulation of inflammatory responses is a promising therapeutic strategy in AD.
After three decades of research, it seems that conventional NSAIDs are not the best pharmacological
option, both for their lack of clear effects and for an unfavorable side-effect profile in long-term
treatment. The development of other anti-inflammatory drugs as candidate treatments in AD may
benefit from the knowledge acquired with NSAIDs.
Computational and Experimental Approaches to Investigate Lipid Nanoparticles as Drug and Gene Delivery Systems
Authors: Chan Chun , Du Shi , Dong Yizhou , Cheng Xiaolin
Published: November 2020

Lipid nanoparticles (LNPs) have been widely applied in drug and gene delivery. More than twenty years ago, DoxilTMwas the first LNPs-based drug approved by the US Food and Drug Administration (FDA). Since then, with decades of research and development, more and more LNP-based therapeutics have been used to treat diverse diseases, which often offer the benefits of reduced toxicity and/or enhanced efficacy compared to the active ingredients alone. Here, we provide a review of recent advances in the development of efficient and robust LNPs for drug/gene delivery. We emphasize the importance of rationally combining experimental and computational approaches, especially those providing multiscale structural and functional information of LNPs, to the design of novel and powerful LNP-based delivery systems.
The Effects of Drugs used for the Treatment of Attention Deficit Hyperactivity Disorder (ADHD) on Pregnancy Outcome and Breast-feeding: A Critical Review
Authors: Ornoy Asher , Koren Gideon
Published: November 2020

Attention deficit/hyperactivity disorder (ADHD) is a neurobehavioral condition found in
5-10% of school-age children and in 2-5% of adults. Stimulants affecting the dopaminergic, noradrenergic
and/or serotonergic systems are commonly used for treatment in children and adults, including
women of childbearing age. The data on the effects of stimulants (methylphenidate and
amphetamines) in pregnancy are generally reassuring, but methylphenidate might slightly increase
the rate of cardiac malformations and of spontaneous abortions, while amphetamines might slightly
increase the risk for premature birth, low birth weight and other pregnancy complications. Bupropion,
a dopamine and norepinephrine reuptake inhibitor, when used as an antidepressant, appears to
be safe in pregnancy. The data on the use of atomoxetine, guanfacine and clonidine in pregnancy
are scarce. Importantly, there are practically no data on the long-term neurodevelopmental effects of
most of these drugs. The published data on the development of children born to methamphetamineabusing
women may be misleading since these women generally use other drugs, including alcohol,
and the home environment where the child is raised may not be optimal. The treating physician
should judge the need for treatment during pregnancy in relation to the severity of the clinical
symptoms. If needed, methylphenidate is preferred over amphetamines because breast feeding is
possible. If one uses non-stimulant medications, bupropion seems to be the preferred drug.
Chemistry of Iodinated Contrast Media (ICM): A Mini Review
Authors: Joshi Maithili P. , Chaudhari Ameya , Kharkar Prashant S. , Joshi Shreerang V.
Published: November 2020

Historically, the use of Iodinated Contrast Media (ICM) for diagnostic purposes, particularly
radiography and Computed Tomography (CT), is well-known. Many of the ICM are included in
the World Health Organization (WHO)’s List of Essential Medicines. Depending on the chemotype
and the presence of ionizable functional group(s), the ICM are categorized into the ionic/nonionic
monomers/dimers. The lipophilicity, aqueous solubility, viscosity and osmolality are major characteristics
dictating their use for one procedure versus the other. Over the last several decades, substantial
advancement has occurred in the design and development of novel ICM, solely to reduce their propensity
to cause adverse effects. Given the nature of their acute usage, some of the agents with appreciable
toxicity are still used. Understanding their chemistry aspects is crucial to appreciate,
acknowledge and justify the usage of these extremely important torch-bearers of the diagnostic
agent’s class. The present review article presents an in-depth overview of the synthetic methods, therapeutic
indications, potential adverse effects along with the commercial and environmental aspects of
ICM. The safety and tolerability of these agents is a field that has gained significant importance,
which is given due importance in the discussion.
Improved Designs of Multifunctional Covalent-Organic Frameworks: Hydrogen Storage, Methane Storage, and Water Harvesting
Authors: Nemiwal Meena , Sharma Venu , Kumar Dinesh
Published: November 2020

:

Covalent Organic Frameworks (COFs) are covalently bonded polymers which are synthesised applying bottomup approach using molecular building units that have pre designed geometry. COFs are crystalline and have control over the
position of building units in two and three dimensions due to which highly regular, rigid and porous structures can be developed for tuning chemical and physical properties of the network. The present mini-review provides comprehensive overviews about the applications of the COFs in gas storage and water harvesting.
Recent Progress in Graphene Derivatives/Metal Oxides Binary Nanocomposites
Based Chemi-resistive Sensors for Disease Diagnosis by Breath
Analysis
Authors: Kalidoss Ramji , Surya Velappa Jayaraman , Sivalingam Yuvaraj
Published: November 2020

Background:

The scientific and clinical interest of breath analysis for non-invasive disease diagnosis has been focused by the scientific community over the past decade. This was due to the exhalation of prominent volatile organic compounds (VOCs) corresponding to the metabolic activities in the body and their concentration variation. To identify these biomarkers, various analytical techniques have been used in the past and the threshold concentration was established between a healthy and diseased state. Subsequently, various nanomaterials-based gas sensors were explored for their demand in quantifying these biomarkers for real-time, low cost and portable breathalyzers along with the essential sensor performances.

Methods:

We focus on the classification of graphene derivatives and their composites’ gas sensing efficiency for the application in the development of breathalyzers. The review begins with the feasibility of the application of nanomaterial gas sensors for healthcare applications. Then, we systematically report the gas sensing performance of various graphene derivatives/semiconductor metal oxides (SMO) binary nanocomposites and their optimizing strategies in selective detection of biomarkers specific to diseases. Finally, we provide insights on the challenges, opportunity and future research directions for the development of breathalyzers using other graphene derivatives/SMO binary nanocomposites.

Results:

On the basis of these analyses, graphene and its derivatives/metal oxides based binary nanocomposites have been a choice for gas sensing material owing to their high electrical conductivity and extraordinary thickness-dependent physicochemical properties. Moreover, the presence of oxygen vacancies in SMO does not only alter the conductivity but also accelerates the carrier transport rate and influence the adsorption behavior of target analyte on the sensing materials. Hence researchers are exploring the search of ultrathin graphene and metal oxide counterpart for high sensing performances.

Conclusion:

Their impressive properties compared to their bulk counterpart have been uncovered towards sensitive and selective detection of biomarkers for its use in portable breathalyzers.
Efficacy and Cardiovascular Safety of Sulfonylureas
Authors: Fernandez Cornelius James , Raveendran Arkiath Veettil , Htwe Nyi
Published: November 2020

There is a universal agreement that when lifestyle modifications are inadequate to control
the hyperglycemia, metformin should be considered the first line of pharmacological therapy.
However, when metformin monotherapy fails, there is no consensus as to which drug should be
added. Many new classes of drugs that are currently available including DPP-4 inhibitors, GLP-1
agonists and SGLT-2 inhibitors have undergone cardiovascular outcome trials which had been
made mandatory by the regulatory authority and thereby established their cardiovascular safety or
at least neutrality. Though sulfonylureas are one of the widely prescribed drugs both in developed
and developing countries and have proven their efficacy for glycemic control and prevention of microvascular
complications, there is considerable uncertainty about its cardiovascular safety which
has been going on for nearly five decades. In this review, we will critically analyze the efficacy
and cardiovascular safety of sulphonylureas, based on the latest available literature to clarify their
role in our day-to-day clinical practice.
COVID-19 Treatment Success After Repeat Courses of Azithromycin: A Report of Three Cases
Authors: Ghiasvand Fereshteh , Ghadimi Maryam , Sadr Sara , Jafari Fatemeh , Manafi Navid , Ahmadinejad Zahra , Tirgar Samaneh , Seyed Alinaghi Seyed Ahmad
Published: November 2020

Background:

Azithromycin has been considered as a possible therapeutic agent for
COVID-19 patients. However, there is limited data on its efficacy.

Case Presentation:

We describe three patients diagnosed with COVID-19 who did not respond to
the initial treatment but improved dramatically upon adding azithromycin with a successful outcome.

Conclusion:

We have presented evidence of the potential beneficial effect of the azithromycin in
the treatment of patients with COVID-19 in three different clinical settings. More evidence is needed
regarding the microbiological data, safety, and efficacy of this medication in the management of
COVID-19.
Ligand Decorated Primaquine Loaded Nanocarriers for Liver Targeting for Triggered Anti-Malarial Activity
Authors: Mehan Paramjot , Garg Ashish , Ajay Kumar , Mishra Neeraj
Published: November 2020

Objective::

The aim of the current research is to formulate a nano delivery system for effective
delivery of primaquine for liver targeting to achieve the potential anti-malarial activity.
Another objective of current development is to formulate a lactobionic acid conjugated polyphosphazene
based nano delivery of primaquine for liver targeting to distinguish anti-malarial activity.

Methods::

The particle size, entrapment efficiency, in-vitro drug release pattern, hepatotoxicity,
MTT assay, erythrocyte toxicity assay, histopathology study, HepG2 cell uptake study, anti--
malarial study, and organ-distribution was also carried out to estimate the activity and potential features
of a nanoparticle system.

Results::

The results obtained from the above analysis justify the efficiency and effectiveness of the
system. The NMR studies confirm the conjugation pattern and the TEM represents the spherical
morphological features of nanoparticles. The controlled release pattern from the in-vitro release
study was observed and found to be 73.25% of drug release in 20 hrs and in the nano-size range
(61.6± 1.56 nm) by particle size analysis.SGOT level, SGPT, ALP, and Parasitemia level of optimized
drug-loaded PEGylated lactobionic acid conjugated polyphosphazene derivatized nanoparticles
(FF) was found to lie in the safe range, showing that the formulation is non-toxic to the liver.
Primaquine drug-loaded PEGylated lactobionic acid conjugated polyphosphazene polymeric nanoparticles
showed higher cell uptake on HepG2 cell lines as compared to the drug-loaded in PEGylated
polyphosphazene polymeric nanoparticles and plain drug.Percentage cell viability of drugloaded
PEGylated lactobionic acid conjugated polyphosphazene derivatized nanoparticles was decreased
by enhancing the concentration of prepared nanoparticle system accessed by MTT assay.

Conclusion::

From the studies, it can be concluded that the optimized formulation of drug-loaded
PEGylated lactobionic acid conjugated polyphosphazene derivatized nanoparticles showed high liver
targeting, least toxicity to the liver, controlled release of the drug, higher anti-malarial activity
against hepatocytes at a low dose, more effectiveness, and can be treated as a potential candidate
for anti-malarial therapy.
Current Opportunities and Challenges in the Incorporation of the LCA Method in BIM
Authors: Durão Vera , Costa António Aguiar , Silvestre José Dinis , Mateus Ricardo , Santos Ruben , de Brito Jorge
Published: November 2020

Background:

In the last years, Building Information Modelling (BIM) and Life Cycle Assessment (LCA) have been integrated to support the pursuit of sustainability in the built environment. However, the integration of environmental information with different specificity and reliability requirements on distinct Levels of Development (LOD) of BIM objects was not yet exploited considering several environmental impact categories.

Objective:

The objective of this paper is to discuss the complexity and depth of LCA information needed for BIM objects, considering different LOD, and to propose a parametrisation of environmental information be included in BIM objects according to their LODs.

Methods:

A literature review on LCA methodology, sources of LCA information, integration of LCA in BIM, and LOD of BIM objects was initially performed, followed by a detailed characterisation of the different types of sources of LCA information to include in BIM models. These steps contributed to the development of the proposed parametrisation of environmental data.

Results:

A parametrisation of environmental information to be included in BIM objects was developed. This parametrisation considered the degree at which the element’s information has been specified (LOD) and the respective detail and reliability of the environmental information to include.

Conclusion:

A new approach is proposed that allows an evolutive integration of environmental information in BIM objects according to their growing LODs.
science in Islamic perspective
Authors: Muslimah Muslimah , Hamdanah Hamdanah , Nina Nina
Published: November 2020

This study aimed to discuss the importance of science and the Islamic perspective's position controller. The data collection of this research was carried out using the library method. Therefore, it is included in library research, preceded by collecting printed and electronic references, sourced from books and articles relating to the meaning, scope, and position of knowledge. We continued to review and explore the connections. The results explain the importance of science from the perspective of Islamic studies, namely that it cannot be separated between human life and progress/civilization. In this context, science and technology are among the branches of knowledge that provide great benefits and benefits to human survival in this world and the hereafter. Islam has glorified people who master science. Even since the Prophet Muhammad was sent to become a prophet, he always exemplified and reminded him to strive for it because he expected Allah SWT's pleased.
Strong state and weak minority in post-civil war Sri Lanka: A study based on state-in-society approach
Authors: Fowsar Mohamed Anifa Mohamed , Fazil Mansoor Mohamed
Published: November 2020

This study aims to analyze the strong state of Sri Lanka that emerged after the civil war during the regime of Mahinda Rajapaksa. The Liberation Tigers of Tamil Eelam (LTTE) was the leading Tamil militant social force, which was waging war against the government to form a separate state in the northern and eastern regions of Sri Lanka. The government ended both the separatist struggle of the LTTE and the civil war in May 2009 by winning a major military victory. This study is a qualitative analysis based on text analysis and field interviews, supplemented with limited observations. The study reveals that the state introduced enhanced security measures to avoid possible LTTE regrouping and re-commencement of violence in the country. The state also attempted to fragment minority parties to weaken the state reconstitution process through penetration and regulation of the social order.
Effect of investment, GRDP percapita, and original local government revenue on regional financial independence through capital expenditure as intervening variables
Authors: Yusiawati Diana , Marhaeni A.A.I.N.
Published: November 2020

This study aims to see the significance of investment, GDRP per capita, Original Local Government Revenue on regional finance independence. This population in this study were districts/cities in Bali Province from 2014 to 2018. This study used a sample with the census method. The data analysis technique used is path analysis. These results showed that investment has a positive and insignificant effect on capital expenditure and has a positive and significant effect on regional finance independence, GRDP per capita has a significant negative effect on capital expenditure and has a significant positive effect on regional financial independence, Original Local Government Revenue (PAD) has a significant positive effect on regional financial independence while the positive and insignificant effect of capital expenditure on regional financial independence.
Causes of interpersonal conflict and biparti institution contribution in handling conflict towards tourism industry
Authors: Sudharma Kadek Januarsa Adi , Haes Putri Ekaresty
Published: November 2020

This article contains the results of interpersonal interactions that occur in the tourism industry. This research is a qualitative study using three data collection techniques, namely observation, interviews, and documentation. The following data retrieval results produce the final results about the causes of interpersonal conflict in the tourism industry, namely (1) differences in the meaning of information to cause discrepancies in the work done, (2) the influence of priorities from tourists. This personal characteristic is caused by the self-concept formed in a person, (3) Unresolved old conflicts so that a compilation of new interpersonal conflicts occurs, old conflicts also contribute. (4) Interpersonal conflict also arises because the leadership style that is applied so that it causes discomfort in work which in the end the work productivity does not decrease.
role of development entrepreneurial orientation and market orientation in improving the performance of creative industry SMEs in Denpasar
Authors: Idawati Ida Ayu Agung , Sumartini Ade Ruly
Published: November 2020

Bali is an area that relies on the tourism industry. The management of the tourism industry cannot be separated from other sectors, such as the creative industry. The creative industry is a supporter of economic growth in increasing employment opportunities and reducing the low population in Indonesia. Fashion and handicrafts are the mainstays of Bali's sub-sectors, with a proportion of 18 percent and 15.4 percent, respectively. The ability of human resources to express their creativity and skills plays an essential role in improving the performance of the relevant SMEs. The purpose of this study was to determine the position of entrepreneurial orientation development and market orientation in enhancing performance and to determine efforts to improve the performance of creative industry SMEs. The analysis technique using multiple linear regression analysis assisted by the SPSS program. The population in this study was the Creative Industry SMEs in the fashion and handicraft sub-sector. The research sample was 40 respondents with the sampling method using convenience sampling. The results of this study indicate that entrepreneurial orientation does not have a significant effect on improving performance.
use of e-commerce during COVID-19 pandemic towards revenue and volume of MSMEs sales
Authors: Mandasari I.A. Cynthia Saisaria , Pratama I Gede Surya
Published: November 2020

A large number of MSMEs in Denpasar City must be able to overcome the challenges caused by the COVID-19 virus and must be able to reach changes around it. Marketing communication must be done as well and as effectively as possible to potential customers. The use of online strategies with e-commerce media is currently the best solution for MSMEs. This is because promotion through online media is easier to reach consumers in terms of introducing or selling their products without having to meet face to face. E-commerce makes it easier for consumers and producers to make transactions. The purpose of this research is to examine the effect of e-commerce on the income and sales volume of MSMEs in Denpasar City. Targeting MSMEs as research respondents. The data collection technique used is a questionnaire technique with a sample of 100 MSME owners. The data obtained will be analyzed using a partial least square (PLS) based structural technique. The results of this study are expected to be able to contribute ideas to related parties, in this case, the community, government, and MSMEs players related to the effect of e-commerce on the income and sales volume of MSMEs.
Leadership and human resource management: response to the COVID-19 outbreak
Authors: Sudarmo Sudarmo
Published: November 2020

This project reviewed the potential for leadership and human resource management in response to the emergence of the COVID-19 pandemic. In any emergency in a country, the role of a leader with the ability and seriousness of human resource management is believed to be very important. To prove this belief, we have collected many-related literature, such as understanding deeply the aspects of leadership and HR management that have been applied successfully in various international contexts. How this leadership role with good management of HR is effectively applied. Because we conducted this study in the pandemic era, an era where restrictions on public movement are being treated, the method of data collection was through engine searches by relying on keyword utility, for example, "leadership potential", "HR management", "responding to the COVID-19 outbreak", and "qualitative studies". Because this study is categorized, we present the results of the study in the descriptive analysis method under the phenomenological approach. For the findings of this review study to meet the principles of validity and trustworthiness, we, the findings of this study, must be able to answer research questions.
Language learning motivation in collaborative online international learning: an activity theory analysis
Authors: Nishio Tomoe , Fujikake Chie , Osawa Masataka
Published: November 2020

This study investigated the development of language learning motivation in an American student of Japanese, Jason, during a mobility-based Collaborative Online International Learning (COIL) project with a Japanese institution. Drawing on an activity theory perspective, this qualitative case study analyzed the student artifacts of the project as well as of interview and fieldnote data to illustrate the transformational process. Findings demonstrate how Jason’s pre-COIL motives (pragmatic, cultural, linguistic, and intellectual) were negotiated while participating in the COIL project. Through interacting with Japanese students, Jason’s preexisting linguistic demotivation was reversed by his positive reevaluation of his own oral skills, which enhanced his desire for higher proficiency. The project also stimulated Jason’s intellectual motive to learn Japanese using technology, leading to his autonomous choice to research language learning and technology, and to create a podcast. It is argued that Jason’s motivation for Japanese learning was enhanced through the social process, during which motives were transformed along with personal significance to him.
Studi Awal Distribusi Temperatur Elemen Bahan Bakar Reaktor Cepat Berpendingin Gas
Authors: Laila Saro Balya Lutviana
Published: November 2020

Tujuan dari penelitian ini adalah menganalisis desain reaktor berdasarkan aspek termalhidrolik dan melakukan perhitungan distribusi temperatur elemen bahan bakar pada kondisitunak. Perhitungan dilakukan secara komputasi dengan menggunakan MATLAB (MATrixLABoratory). Metode yang digunakan ialah studi literatur dan perhitungan komputasi. Studi awal distribusi temperatur elemen menggunakan bahan bakar reaktor cepat berpendingin gas atau Gas cooled Fast Reactor (GFR). GFR ini didesain dengan bahan bakar uranium metal (U-10%wtZr), pendingin Helium (He), kelongsong stainless steel 316 (SS316) dan daya 500 MWt. Untuk menghitung distribusi temperatur elemen bahan bakar maka akan digunakan dengan asumsi distribusi kerapatan daya di dalam bahan bakar merata ke segala arah baik untuk arah radial maupun aksial dan transfer panas berlangsung pada keadaan tunak untuk 1 kanal pendingin. Perhitungan distribusi temperatur elemen bahan bakar pada kondisi tunak dilakukan dengan menggunakan persamaan-persamaan yang diadaptasi dari Duderstadt dan Hamilton. Hasil penelitian ini menunjukan bahwa reaktor berada dalam batas aman dengan temperatur maksimum berada di bawah nilai titik leleh bahan bakar, sehingga dari keadaan ini dapat menunjang keamanan pengoperasian reaktor.PRELIMINARY STUDY OF THE ELEMENT TEMPERATURE DISTRIBUTION OF GAS-COOLED FAST REACTORT. The study was aimed at analyzing the design of the reactor based on thermal-aspects and calculating the temperature distribution of the fuel element under steady conditions. The calculations were done computationally using MATLAB (MATrix LABoratory). The method used was the study of literature and computational calculations. Preliminary studiesof the temperature distribution of the elements using a gas-cooled Fast Reactor (GFR). The GFR is designed with uranium metal fuel (U-10% wtZr), Helium cooler (He), 316 stainlesssteel cladding (SS316) and 500 MWt power. To calculate the temperature distribution of the fuel element, assuming the distribution of the power density in the fuel is evenly distributed in all directions. All directions for both radial and axial direction and heat transfer took place under steady-state for 1 cooling channel. The calculation of the temperature distribution of the fuel element under steady-state performed using equations adapted from Duderstadt and Hamilton. The results of this study indicate that the reactor is within safe limits with maximumtemperatures below the value of the melting point of the fuel.The conclusion was it is able to support the safety of the reactor operation.
ANALISIS USABILITY PADA SISTEM INFORMASI AKADEMIK MAHASISWA UNIVERSITAS MUHAMMADIYAH RIAU MENGGUNAKAN METODE SYSTEM USABILITY SCALE (SUS)
Authors: Sari Widad Ulfika
Published: November 2020

Sistem informasi akademik merupakan media yang dapat membantu proses berjalannya kegiatan akademik. Kelancaran proses akademik dipengaruhi oleh kualitas sistem informasi yang dimiliki. Sistem dapat dikatakan memiliki tingkat usability yang tinggi apabila pengguna bisa memperoleh apa yang mereka butuhkan dan mengerti dengan sistem tersebut. Universitas Muhammadiyah Riau menerapkan sistem informasi untuk membantu proses akademiknya yaitu SIAM. Saat ini, terdapat beberapa kendala dalam mengakses sistem tersebut. Kendala tersebut berasal dari beberapa kekurangan yang dimiliki oleh sistem tersebut. Oleh karena  itu, penelitian ini bertujuan untuk mengidentifikasi permasalahan pada SIAM, mengetahui tingkat usability nya, dan memberikan rekomendasi perbaikan SIAM.  Penelitian ini dilakukan dengan menggunakan metode System Usability Scale (SUS). Hasil yang diperoleh adalah SIAM memiliki skor SUS sebesar 72,27 yang berarti bahwa SIAM sudah acceptable, memiliki skala nilai C+ dan memiliki rating good atau baik serta nilai percentile rank berada pada nilai 63,34. Pada identifikasi masalah diketahui bahwa fungsi dan fitur pada SIAM dinilai masih belum dirancang dengan baik dan memiliki banyak inkonsistensi. Oleh karena itu diberikan beberapa rekomendasi perbaikan yang diharapkan dapat dijadikan sebagai rujukan bagi tim pengembang sistem dalam melakukan perbaikan usability sistem sehingga SIAM memiliki tingkat usability yang tinggi dan dapat mencapai kepuasan pengguna.
SINTESIS ANALOG KURKUMIN 2,6-BIS-(E)-4-HIDROKSI-3-METOKSI BENZILIDIN)-SIKLOHEKSA-1-ON BERBAHAN DASAR VANILIN DENGAN KATALIS HCl
Authors: Martha Rahma Diyan
Published: November 2020

Kurkumin merupakan senyawa yang potensial untuk dikembangkan. Stabilitas kurkumin dipengaruhi oleh pH lingkungan dan cahaya karena ada gugus metilen aktif pada β-diketon. Oleh karena itu, dibutuhkan modifikasi gugus β-diketon sehingga dapat meningkatkan stabilitas dari analog kurkumin. Dalam penelitian ini, sintesis senyawa analog kurkumin berbahan dasar vanillin sebagai sumber benzaldehida dan sikloheksanon sebagai sumber keton dengan katalis asam (HCl) telah dilakukan. Metode analisis dilakukan secara kualitatif yaitu dianalisis dengan KLT dan instrumentasi FTIR, direct-MS, 1H NMR dan 13C NMR. Dari hasil analisis titik leleh, KLT, FTIR, direct-MS, 1H- dan 13C-NMR dapat disimpulkan bahwa senyawa target telah terbentuk berupa padatan warna kuning kehijauan, memiliki titik leleh 210-212 °C dan rendemen 53,00% serta hasil KLT terdapat spot baru yang berfluorosensi
Image representation based on fractional order Legendre and Laguerre orthogonal moments
Authors:   Department of Mathematics, Faculty of Science, Zagazig University, Zagazig, Egypt, Farouk R. M. , Awad Qamar A. A. ,   Department of Mathematics, Faculty of Science, Zagazig University, Zagazig, Egypt
Published: November 2020

In this paper, we have introduced new sets of fractional order orthogonal basis moments based on Fractional order Legendre orthogonal Functions (FLeFs) and Fractional order Laguerre orthogonal Functions (FLaFs) for image representation. We have generated a novel set of Fractional order Legendre orthogonal Moments (FLeMs) from fractional order Legendre orthogonal functions and a new set of Fractional order Laguerre orthogonal Moments (FLaMs) from the fractional order Laguerre orthogonal functions. The new presented sets of (FLeMs) and (FLaMs) are tested with the recently introduced Fractional order Chebyshev orthogonal Moments (FCMs). This edge detection filter can be used successfully in the gray level image and color images. The new sets of fractional moments are used to reconstruct the gray level image. The numerical results show FLeMs and FLaMs are promised techniques for image representation. The computational time of the proposed techniques is compared with the computational time of Chebyshev orthogonal Moments techniques and gives better results. Also, the fractional parameters give the flexibility of studying global features of the image at different positions of moments.