bluuebunny/crossref_metadata_2025 huggingface dataset:
Estimation of Soil Characteristic Parameters for Electric Mountain Tractor Based on Gauss–Newton Iteration Method
Authors: Xi Zhiqiang , Feng Tian , Liu Zhijun , Xu Huaijun , Zheng Jingyang , Xu Liyou
Published: May 2024

Future field work tasks will require mountain tractors to pass through rough terrain with limited human supervision. The wheel–soil interaction plays a critical role in rugged terrain mobility. In this paper, an algorithm for the estimation of soil characteristic parameters based on the Simpson numerical integration method and Gauss–Newton iteration method is presented. These parameters can be used for passability prediction or in a traction control algorithm to improve tractor mobility and to plan safe operation paths for autonomous navigation systems. To verify the effectiveness of the solving algorithm, different initial values and soils were selected for simulation calculations of soil characteristic parameters such as internal friction angle, settlement index, and the joint parameter of soil cohesion modulus and friction modulus. The results show that the error was kept within 2%, and the calculation time did not exceed 0.84 s, demonstrating high robustness and real-time performance. To test the applicability of the algorithm model, further research was conducted using different wheel parameters of electric mountain tractors under wet clay conditions. The results show that these parameters also have high accuracy and stability with only a few iterations. Thus, the estimation algorithm can meet the requirements of quickly and accurately identifying soil characteristic parameters during tractor operation. A criterion for the passability of wheeled tractors through unknown terrain is proposed, utilizing identified soil parameters.
Examining the Intersection of Sociopolitical Development and Transformative Social and Emotional Learning Outcomes: An Integrated Approach in Youth Participatory Action Research
Authors: Nash Amia , Kennedy Heather , Abraczinskas Michelle , Ballonoff Suleiman Ahna , Ozer Emily J.
Published: May 2024

Young people need opportunities that support their well-being while enabling them to take meaningful action. There has been strong interest in youth participatory action research (YPAR) as a form of sociopolitical action for marginalized youth seeking to address inequities that undermine individual and community well-being. The rapid growth of the YPAR literature in the last decade has involved studies analyzing the impact of YPAR on dimensions of youth empowerment, sociopolitical development (SPD), and well-being. The relatively new framework of Transformative Social Emotional Learning (tSEL) is potentially fruitful in identifying relevant constructs, skills, and strategies to support well-being during the YPAR process. This article seeks to advance our integrative conceptualization and analysis of the impact of YPAR by (1) considering the overlapping and unique dimensions of SPD and tSEL: agency, belonging, collaborative problem solving, curiosity, identity, societal involvement, and worldview and social analysis; and (2) applying this integrative lens to the analysis of novel data from an updated systematic review of U.S. and international YPAR studies (2015–2022). We summarize youth outcomes reported in 25 studies to assess the evidence for YPAR as an approach for promoting youth SPD and tSEL outcomes, identifying limitations and next steps for advancing our understanding of these impacts.
Gamification in business and entrepreneurship education – theory and applications
Authors: Marinov Eduard , Spasova Elena
Published: May 2024

The aim of this study is to systematize the main advantages and difficulties in the use of game elements in entrepreneurship education. It will examine the expected effects of their application on the quality of education and the level of skills acquired. The first part discusses the need to rethink the way in which entrepreneurship education is conducted in relation to new opportunities provided by technology, but also due to the changing needs and ways of training new generations. The next section analyzes the various possibilities for applying “gaming” practices in training and linking them with a systematic framework for the acquisition of knowledge, skills and competencies. The last part presents the methodology used by the authors to create a gaming platform for entrepreneurship education. The final part summarizes some conclusions and makes recommendations for the use of gamification in education in the field of business, entrepreneurship and economics in secondary and higher education.
Opportunities and limitations of digital educational tools in shaping entrepreneurial mindset and competences
Authors: Kolarov Kostadin , Hadjitchoneva Juliana
Published: May 2024

This paper examines the potential of digital learning environments in preparing future entrepreneurs through higher education. Despite historic doubts regarding the systematic teaching of entrepreneurial skills, in recent decades entrepreneurship education has distinctly evolved. Unlike conventional professions, entrepreneurship encompasses a diverse array of specific challenges in business creation and management. This makes it challenging to adopt a uniform educational approach. Hence, a blend of appropriate educational methods is essential. These range from inspiring learners through entrepreneurial narratives to fostering conceptual and practical skills for recognizing opportunities, validating business ideas, gaining knowledge and skills for managing processes and resources, and cultivating personal attributes crucial for entrepreneurial success. The paper critically evaluates the potential of digital learning environments in nurturing entrepreneurial competencies. This is achieved by juxtaposing the outcomes of existing theoretical and empirical studies on the utilization of digital tools in entrepreneurship education. The research aims to address crucial questions: what, how, and by whom should entrepreneurship be taught; the distinct advantages and limitations of various digital tools in fostering specific entrepreneurial competencies; and to what extent digital learning environments can enhance the overall effectiveness of entrepreneurship education, considering the extent of resources committed. The array of digital tools encompasses virtual learning environments, interactive communication channels, multimedia products, engaging learning content, and specialized software for practical activities. The research adopts an exploratory methodology, applying qualitative methods. An online questionnaire was conducted to explore the perspectives of current entrepreneurship students in two Bulgarian universities. The paper concludes that digital learning environments indeed have the potential to significantly enhance the overall effectiveness of entrepreneurship education. However, a discerning approach is essential when selecting the appropriate digital tools tailored to foster distinct entrepreneurial competencies, considering the specific stage of the entrepreneurial learning process. Different digital facilitators demonstrate varying degrees of efficacy in shaping the mindset and competencies of future entrepreneurs in determining entrepreneurial opportunities, cultivating relationships, conceptualizing, organizing, strategizing, and displaying commitment.
Ways to prevent ISMP by changing the behavioral approach of health care workers
Authors:   Federal State Autonomous Educational Institution of Higher Education «Russian University of Peoples’ Friendship named after Patrice Lumumba», Antushko T. D.
Published: May 2024

The article presents foreign experience in implementing a program for the prevention of HAI through changes in behavior and skills acquired during the ongoing training of medical personnel. The need and importance of creating program modules for each target audience of medical personnel is emphasized.
Rehabilitation of burnout patients: medical and psychological aspects
Authors:   SBHI Sanatorium-Resort Complex «Podmoskovye» of the Ministry of Defense of Russia, Moscow, Russia, Sobolev A. V. , Ponomarenko G. N. ,   SBHI Federal Scientific and Educational Centre of Medial and Social Expertise and Rehabilitation named after G. A. Albrecht of the Ministry of Labor of Russia, St. Petersburg, Russia; FSBEI HE North-Western State Medical University named after I. I. Mechnikov of the Ministry of Health of Russia, St. Petersburg, Russia
Published: May 2024

Abstract. Rationale: Determining the therapeutic effects of rehabilitation technologies in patients with burnout is a topical scientific and practical task. Purpose of the study: to determine the therapeutic effects of combinations of rehabilitation technologies in patients with burnout. Methods: 208 patients aged 31.9 (18–52.0) years with burnout (ICD-10 code Z73.0) were studied. The patients were prescribed a set of physical exercises, a course of audiovisual polysensory relaxation, transcranial magnetic therapy, non-selective chromotherapy, therapeutic massage, contrast showers (baths), climatotherapy, clinical nutrition, and psychotherapy. The total duration of the course was 20–30 days. Clinical, instrumental, psychophysical, and integral methods of assessing the condition of patients were used. Results: the study revealed significant dynamics of indicators of subjective well-being: interest in professional activity, attention to detail, psychophysiological status, heart rate, systolic arterial pressure, vital capacity, double product and the Martinet-Kushelevsky test, adaptive potential, and vegetative regulation. The rehabilitation course caused a significant improvement in integral health indicators: the level of somatic health increased from 1.75 ± 0.52 to 2.9 ± 0.58 points (p < 0.001) and physical performance indicators PWC-170 — from 866.6 ± 10.2 to 1,031.1 ± 11.8 mcg/s (p < 0.001). Conclusion: the complex of syndrome and pathogenetically conditioned rehabilitation technologies forms pronounced actoprotective and psychorelaxing therapeutic effects in patients with burnout.
Change in parameters of the microcirculatory tissue system of the peri implant zone in patients with peri implantitis during complex use of mesodiencephalic modulation and ozone therapy
Authors:   Federal State Budgetary Educational Institution of Higher Education «North Ossetian State Medical Academy» of the Ministry of Health of the Russian Federation, Vladikavkaz, Russia, Balaeva M. R. , Nagornev S. N. ,   Federal State Budgetary Institution of Continuing Professional Education «Central State Medical Academy» of the Presidential Administration of the Russian Federation, Moscow, Russia, Remizova A. A. ,   Federal State Budgetary Educational Institution of Higher Education «North Ossetian State Medical Academy» of the Ministry of Health of the Russian Federation, Vladikavkaz, Russia
Published: May 2024

Abstract. Purpose of the study: The article examines the role of microcirculation disorders in the pathogenesis of peri-implantitis in patients after dental implantation. Materials and methods. It is shown that the development of peri-implantitis is characterized by significant changes in the parameters of microhemodynamics and oxygen exchange in the tissue involved in the inflammatory process. The state of oxygen and energy deficiency prompts the progression of inflammatory changes with the formation of signs of tissue destruction around dental implants. The application of a standard scheme of peri-implantitis therapy is accompanied by a correction of the microcirculatory tissue system indicators. The supplementation of standard treatment with course use of medical physical factors promotes the strengthening of the positive dynamics of microcirculation parameters of the peri-implant zone. The corrective influence of MDM-therapy is connected with the activation of the mechanisms of neuroendocrine regulation of vegetative functions, while the basis of ozone therapy is the polymodality of the factor, including the relaxation of the precapillary blood flow, improvement of the rheological properties of the blood, and the stimulating effect on angiogenesis processes. Results. The complex application of medical physical factors, combining systemotropic and local impacts, different modalities and points of application of their corrective activity, contributes to the manifestation of functional potentiation with a maximal corrective effect.
Reducing the number and staff: the final stage
Authors:   Department of Labor Law, Ural State Law University named after V.F. Yakovlev (Ural State University named after V.F. Yakovlev), Yekaterinburg, Ivanchina Ju. V.
Published: May 2024

The article covers one of the stages of the procedure for reducing the number or staff of employees, i.e. the offer of transfer to another job and the consideration of the motivated opinion of a trade union when dismissing a trade union member. Attention is paid to the distinction between vacant and vacant positions. The requirements for determining vacant positions to be offered to an employee and the procedure for offering them are disclosed. The complexities faced by employers in the process of implementing dismissal on this basis are outlined.
Realization of the right to training and additional professional education of medical workers: analysis of judicial practice
Authors:   Department of Labor Law, V.F.Yakovlev Federal State Budgetary Educational Institution of Higher Education, Yekaterinburg, Kuchina Y.A.
Published: May 2024

The possibility of professional and personal development is considered as a factor that positively affects the quality of working life of medical workers. At the same time, providing the healthcare system with qualified personnel also contributes to the achievement of Russia’s national development goals. To assess the protection of professional skills, the author analyzes judicial practice regarding the implementation of the right of medical workers to training and additional professional education, highlighting the main causes of labor disputes and proposing options for their resolution.
Possibilities of using interim measures in cross-border labor disputes: problem statement
Authors:   Yaroslavl State University named after P.G. Demidov, Maksurov A.A.
Published: May 2024

The article discusses problematic issues of applying interim measures in cross-border labor disputes. The purpose of the work is to clarify the problems of adapting existing interim measures to these types of legal disputes. The results of the work are of scientific importance, since they allow us to streamline knowledge about the use of interim measures when considering cross-border labor disputes, and also represent practical significance for participants in such disputes, their representatives and courts. These issues are considered for the first time in the literature from the point of view of the problems of their resolution not only by the courts, but also by executive authorities called upon to execute judicial acts on measures to ensure claims in individual labor disputes.
La figure mythique du chamane dans ses représentations audiovisuelles occidentales
Authors: Stépanoff Charles
Published: May 2024

Le chamanisme, notion de vulgarisation récente qui tend à recouvrir celle de sorcellerie, est l’objet dans nos sociétés d’une fascination croissante. Le chamane est devenu le héros d’un véritable mythe dont il est intéressant de recueillir les traits caractéristiques. En particulier, les productions audiovisuelles sont autant de variantes du mythe qui, en plus de le reformuler, lui donnent une confirmation objectivante en vertu de la transparence présumée de l’image. Mettant en doute un tel postulat, cet article s’attache à analyser dans plusieurs productions diffusées en France le travail efficace d’un mythe savant.
Chamanisme et transformation sociale à Touva
Authors: Stépanoff Charles
Published: May 2024

Shamanism and social transformation in Tuva

During the last ten years, the Republic of Tuva has seen a rebirth of shamanism in urban areas in radically new institutional forms. After a description of the principal shamanist associations, this article presents the problems of competition and legitimacy connected to these brutal changes.
Le jeu rituel musical (glu/klu rol) du village de Sog ru (Reb gong) en A mdo
Authors: Buffetrille Katia
Published: May 2024

Cet article traite de la question du rapport entre jeu et rite à travers l’étude du jeu rituel musical (glu/ klu rol) de Sog ru, en A mdo (Tibet septentrional). Ce rituel festif, dédié aux divinités locales, est exécuté par les laïcs dans le but d’obtenir prospérité et bonne fortune et de chasser les calamités. Les diverses séquences sont appelées « jeux » (rtsed mo) et les villageois qui les exécutent « joueurs » (rtsed mo rtsed mkhan). L’auteur s’interroge sur les raisons de la présence de « jeux » dans ce rituel alors qu’ils sont absents du culte au « dieu du terroir ».
Les voies du corral. Aspects de l'orientation dans les pratiques pastorales et les performances rituelles contemporaines des éleveurs de rennes du Nord-Kamtchatka
Authors: Plattet Patrick
Published: May 2024

Herding directions. Aspects of orientation in contemporary pastoral practices and ritual performances of reindeer herders in northern Kamchatka

Among the reindeer herders of northern Kamchatka far east Siberia, Russian Federation), pastoral practices and ritual performances reveal a similar connection to orientation. In the village of Ačajvajam, this relationship expresses itself explicitly in the spring, when Chukchee, Even and Konak herders together build a corral in order to separate the female reindeer from the rest of the herd before calving time, and then celebrate the birth of the fawns in the residential outskirts of their village. Never consistently fixed, the pragmatic and symbolic marks of orientation determine a moving topography in which the positions of humans, animals and “spirits” sometimes overlap with one another or even take the place of each other. In this perpetual movement, body gesture (dancing) and vocal gesture (guttural sounds, melodic singings) appear as powerful markers of orientation.
Un espace à l'aune du bétail
Authors: Ferret Carole
Published: May 2024

Space marked out with livestock

Searching for traces of pastoral activity in Turkic-Mongol space categories, we discover that measurement of distance is rather relative, whereas orientation is rather absolute. The norms governing orientation are so strict that inversion of positions is linked to death.
Orientation des monastères mongols
Authors: Charleux Isabelle
Published: May 2024

The orientation of Mongolian monasteries

The article treats the question of whether orientation becomes particularly important in the architecture of Mongolian Buddhist monasteries built between the 16th and the 20th century. While the monasteries were oriented, the orientation was multiple: Indo-Tibetan Buddhist influences, Chinese influences, and the Mongolian conception of space all played contrasting roles in the choices of the right setting (by means of geomancy), the monument’s inscription in the landscape, the buildings’ general orientation, the hierarchy between different positions (right and left, high and low, entrance and back), and their general layout. As a consequence, various models coexist: axial temples, maṇḍala temples and stūpa are built according to either an axial progression or centred and oriented cosmological models. Furthermore, some sites are built in an apparently disorderly layout or settlement, which bears little resemblance to a cosmological model. Yet, such sites will be “corrected” in literary or pictorial representations, by evincing telling discrepancies between the discourse and the reality of orientation. Finally we discuss the practice of circumambulation which unites spatial and temporal progressions.
Les mélodies huchées des Touvas et des Ouzbèks. Contexte et système musical
Authors: Léotar Frédéric
Published: May 2024

Tuvinian and Uzbek taming melodies. Context and musical system

Based on concrete examples, this article seeks to illustrate the thesis that songs for animals or so-called taming melodies used by Turkic shepherds proceed from a similar prototypic model. Following a detailed inventory of all descriptions available in the ethno-musical and linguistic literature about the use of a song to incite, for instance, females to produce milk, the analysis focuses on Tuvinian and Uybek taming melodies. The analysis points out recurrences in the melodies, which reveals an underlying common model.
The Seven Rongtsan Brothers in Ladakh. Myth, territory and possession
Authors: Dollfus Pascale
Published: May 2024

Called “local gods” (yul lha), the Seven Rongtsan brothers are found in different places all over Ladakh, but always linked in some way to royal estates. Every year, on fixed festival days, they manifest themselves through a medium — a layman or a monk — in an outdoor séance. They offer advice and deliver prophecies about calamities, weather and the forthcoming harvest. This paper examines the various accounts related to their introduction to Ladakh, and gives a description of each of the Seven Brothers, detailing their temper and attributes. Lastly, it explores the close relations they maintained with rulers, referred to as kings, through the centuries.
Une source cadastrale du district de Temnikov (1613/14). Lecture continue et étude statistique
Authors: Teiro Élisabeth
Published: May 2024

À l’issue du Temps des Troubles fut lancée une description des terres de l’État russe nécessaire au pouvoir nouvellement installé. La dozornaja kniga du district de Temnikov, établie en 1613/14 par Ivan Usov et ses collègues, est une des rares sources cadastrales de ce type qui nous est parvenue. Sa valeur pour l’histoire des cadastres comme pour l’histoire des Tatars est incontestable. L’auteur présente ici les remarques qui se sont imposées à elle lors de la lecture suivie et de l’étude statistique de cette source. Elle aborde notamment les méthodes de compilation du cadastre, les caractéristiques du peuplement et de la population, la question religieuse, le statut de détenteurs de biens-fonds et insiste sur les questions auxquelles ne permet pas de répondre ce document.
Histoire du musée régional V.A. Obručev de Kiakhta
Authors: Smol’nikova E. V. , Xarabadze N. A.
Published: May 2024

L’article retrace les différentes étapes de la fondation du Musée régional de Kiakhta, mettant en lumière le dynamisme des habitants de la ville comme l’aide apportée par les hôtes de passage - notamment les ethnographes G. N. Potanin et D. A. Klemenc. Créé en 1890, le musée ne reçut de statut officiel qu’une fois rattaché à la filiale de Troitskosavsk-Kiakhta de la Société impériale de géographie, créée en 1894. L’histoire de la constitution des collections de même que les transformations subies à la période soviétique par le musée - l’un des plus importants de Transbaïkalie - rendent compte de tout un pan de l’histoire de la ville de la fin du XIXe siècle à nos jours.
ANALISIS KINERJA KEUANGAN BANK UMUM KONVENSIONAL KBMI 3 TAHUN 2017-2022
Authors: Trisnawati Luh Putu Puji , Alfayed Jonathan Tristan
Published: May 2024

In general, the purpose of an established company is to make a profit for its owners. A company that performs well can generate high profits with a long period of time and is able to attract investors to invest its funds. One form of information that can be used to determine the condition and development of a company is the financial statements reported at the end of each period as a report on management accountability for the management of a company. Company performance is a description of the financial condition of a company that is analyzed with various financial analysis tools, so that it can be known about the good and bad financial condition of a company that reflects performance achievements in a certain period. This study aims to analyse the financial performance of core capital group (KMBI) 3 banks using Otoritas Jasa Keuangan (OJK) report data for the period 2017 - 2022 which is processed using the Eviews application. The results of the study found that Capital Adequacy Ratio (CAR) has a significant positive influence on company performance in this case Return On Asset, Non Performing Loan (NPL) does not have a significant effect on Return On Asset, Loan To Deposit Ratio (LDR) has a significant positive influence on Return On Asset and Operating Expense to Opeating Income (BOPO) has a significant negative influence on Return On Asset.

Key words: Financial Performance, Commercial Banks, Core Capital Bank Group 3
PENGARUH HARGA DAN KUALITAS PRODUK TERHADAP KEPUTUSAN PEMBELIAN PRODUK BITTERSWEET BY NAJLA DENGAN KEPUASAN KOSUMEN SEBAGAI VARIABEL MEDIASI
Authors: Pratama Arya Yudha , Wiyadi Wiyadi
Published: May 2024

The research was conducted by measuring the influence that product price and quality have on purchasing decisions by paying attention to consumer satisfaction as a mediating variable. Furthermore, bittersweet by Najla was chosen as the research object because of its popularity. Through the purposive sampling method, measurements using quantitative methods were obtained by distributing questionnaires to consumers of Bittersweet Najla who are 15 years old, as well as people who like sweet foods, so a total of 175 respondents were obtained. The findings show that customer satisfaction and price and product quality influence purchasing decisions, not only a direct influence but also a mediating influence on consumer satisfaction which also has a significant impact on the relationship between price and product quality on purchasing decisions.

Key words: Price, Product Quality, Purchasing Decisions, Consumer Satisfaction
The Effect of Educational Intervention Based on PRECEDE Model on Improving Self-care Behaviors of Diabetic Elderly
Authors: Ghalegolab Farzaneh , Teravatmanesh Samira , Sobhani Ali , Khani Jeihooni Ali
Published: May 2024

Introduction: Improper lifestyle and unfavorable self-care in diabetic patients have led to the emergence and spread of complications and problems caused by the burden of the disease. This study was conducted with the aim of determining the effect of an educational intervention based on the PRECEDE model on improving the self-care behaviors of diabetic elderly. Methods: This is a semi-experimental study that was conducted on 200 elderly people with diabetes referring to Fasa diabetes centers in 2019-2020. The experimental group was trained in self-care skills based on the PRECEDE model in 6 training sessions of 50-55 minutes. Before and after the intervention, the self-care behaviors of the patients and the constructs of the PRECEDE model were measured in both groups using questionnaires. After entering the SPSS version 20 software, the data were analyzed using independent t-test, paired t-test and chi-square test. Results: In the experimental group, the average score of their self-care behaviors increased significantly from 101.31±36.2 to 139.01±35.8 (P<0.001), also in the experimental group, the mean scores of all constructs of the PRECEDE model increased significantly after the intervention (P<0.05). In the control group, there was no significant change in the average score of the constructs of the PRECEDE model and self-care behaviors before and after the intervention (P>0.05). Conclusion: The results of the study indicated the effectiveness of the educational program based on the PRECEDE model on improving the self-care behaviors of the elderly with diabetes.
CRISPR-Cas9 in basic and translational aspects of cancer therapy
Authors: Samareh Salavatipour Maryam , Poursalehi Zahra , Hosseini Rouzbahani Negin , Mohammadyar Sohaib , Vasei Mohammad
Published: May 2024

Introduction: The discovery of gene editing techniques has opened a new era within the field of biology and enabled scientists to manipulate nucleic acid molecules. CRISPR-Cas9 genome engineering has revolutionized this achievement by successful targeting the DNA molecule and editing its sequence. Since genomic changes are the basis of the birth and growth of many tumors, CRISPR-Cas9 method has been successfully applied to identify and manipulate the genes which are involved in initiating and driving some neoplastic processes. Methods: By review of the existing literature on application of CRISPR-Cas9 in cancer, different databases, such as PubMed and Google Scholar, we started data collection for "CRISPR-Cas9", "Genome Editing", "Cancer", "Solid tumors", "Hematologic malignancy" "Immunotherapy", "Diagnosis", "Drug resistance" phrases. Clinicaltrials.gov, a resource that provides access to information on clinical trials, was also searched in this review. Results: We have defined the basics of this technology and then mentioned some clinical and preclinical studies using this technology in the treatment of a variety of solid tumors as well as hematologic neoplasms. Finally, we described the progress made by this technology in boosting immune-mediated cell therapy in oncology, such as CAR-T cells, CAR-NK cells, and CAR-M cells. Conclusion: CRISPR-Cas9 system revolutionized the therapeutic strategies in some solid malignant tumors and leukemia through targeting the key genes involved in the pathogenesis of these cancers.
Application of a Deep Eutectic Solvent for the Synthesis of Novel Imidazole-Containing Quinazoline Derivatives as Potent Cytotoxic Agents
Authors: Azmian Moghadam Fatemeh , Dabirian Sara , Ebrahimi Tavani Amin , Alipour Parisa , Mojabi Mohammad , Evazalipour Mehdi , Yousefbeyk Fatemeh , Ghasemi Saeed
Published: May 2024

Background: Drugs containing the 4-anilinoquinazolines scaffold play a critical role in cancer treatment by inhibiting protein kinases, especially tyrosine kinases. In this study, a novel series of 4-anilinoquinazoline derivatives were synthesized and evaluated as cytotoxic agents. Methods: All final compounds were synthesized using two methods, including a conventional approach using potassium iodide and dimethylformamide as well as a green method using a deep eutectic solvent (DES) comprising choline chloride: urea. The cytotoxicity was tested on the A431, HUVEC, and HU02 cell lines. To evaluate the binding pattern of the compounds with EGFR and VEGFR-2, a molecular docking investigation was performed. Finally, the wound healing assay was carried out to assess the potency of compounds in inhibiting cell migration. Results: The final reaction time was approximately 15-20 min with yields of 60-72% using DES, while the conventional method took 3 to 4 h to complete, with yields between 30% and 42%. Compounds 8k and 8l showed better cytotoxicity against both cell lines compared to vandetanib (IC50=0.11 µM and 0.26 µM on A431 and IC50=5.01 µM and 5.24 µM on HUVEC, respectively). Molecular docking studies revealed that compound 8k, which contained 3-methylaniline at the 4-position of the quinazoline core, showed efficient binding affinity to both EGFR and VEGFR-2. An essential hydrogen bond was formed between quinazoline N1 of 8k and the Met796 residue of EGFR with a docking score of -8.76 kcal/mol. The imidazole N3 of 8k interacted with the Cyc919 residue of VEGFR-2, forming a hydrogen bond with a docking score of -9.03 kcal/mol. Moreover, compound 8k exhibited the best inhibitory activity on cell migration and wound healing. Conclusion: DES significantly improved the time and yield of the final reactions. Compound 8k, which showed the best cytotoxicity and inhibitory activity on cell migration, could be a suitable candidate for further structural optimization.
Risk Factors for Acute Kidney Injury in Patients Receiving Intravenous Colistin
Authors: Katip Wasan , Oberdorfer Peninnah , Taruangsri Puntapong , Nampuan Teerapong
Published: May 2024

Background: Colistin use is primarily associated with nephrotoxicity, which has been shown to be reversible with a low incidence of long-term kidney impairment. This study aimed to investigate the risk factors for acute kidney injury (AKI) in patients receiving intravenous colistin. Methods: A retrospective cohort study was conducted at Nakornping Hospital in northern Thailand from 2015 to 2020. Adult patients who received intravenous colistin were included, while those with chronic kidney disease or prior renal replacement therapy were excluded. The study assessed potential AKI risk factors, including demographics, comorbidities, and concurrent use of medications. Cases of AKI are identified among the cohort, while the control group includes individuals not experiencing AKI during the follow-up but similar to the cases in terms of the exposure. Univariate and multivariable logistic regression analyses were performed to identify risk factors associated with AKI. Results: Among the 206 patients included in the study, a majority were admitted to the intensive care unit, required mechanical ventilation, and experienced septic shock. Univariate analysis revealed diabetes (odd ratio (OR)=2.82, 95% CI: 1.21–6.59, p=0.016), malignancy (OR=2.06, 95% CI:1.12–3.77, p=0.020), and baseline Scr (OR=0.71, 95% CI: 0.51–0.99, p=0.048) as significant risk factors for AKI. Multivariate analysis confirmed the association of diabetes (adjusted odd ratio(aOR)= 3.09, 95% CI: 1.20–7.96, p=0.019), malignancy (aOR= 2.31, 95% CI: 1.18–4.52, p=0.015), septic shock (aOR = 2.80, 95% CI: 1.02–7.69, p=0.045), and vasopressor use (aOR = 2.85, 95% CI: 1.12–7.23, p=0.028) with an increased risk of AKI. Conversely, baseline Scr (aOR = 0.54, 95% CI: 0.36–0.82, p=0.004) were associated with a decreased risk of AKI. Other factors, including concomitant use of aminoglycosides, vancomycin, rifampin, combination therapy, nephrotoxins, hypertension, and intensive care unit admission, did not show significant associations. Conclusion: This study identified diabetes, malignancy, septic shock, and vasopressor use as significant risk factors for AKI in patients receiving colistin. Baseline Scr levels were found to be inversely associated with the risk of AKI. These findings contribute to a better understanding of colistin-related nephrotoxicity and can guide clinical management to mitigate the risk of AKI in this patient population.
Book Review: Surprised Again! The COVID Crises and the New Market Bubble
Authors: Newman Patrick
Published: May 2024

The COVID recession in early 2020 rocked the United States economy. Output and the stock market tanked before unprecedented fiscal and monetary policies brought everything roaring back to life. Surprised Again! by Mises Institute senior fellow Alex J. Pollock and Howard B. Adler tells this story.
Comparación entre Mora-Vahrson y Lógica difusa en la susceptibilidad a movimientos de tierra en el cantón Morona – Amazonía ecuatoriana
Authors: Palacios Orejuela Iván Fernando
Published: May 2024

Los deslizamientos históricamente han causado mayores daños en el planeta, y representan aproximadamente el 17% del total de muertes provocadas por riesgos naturales a nivel mundial. Lastimosamente, debido a los efectos del cambio climático se pronostica que las pérdidas humanas y económicas no disminuyan. Existen varias metodologías para mapear la susceptibilidad a deslizamientos, de las cuales a nivel regional de Latinoamérica se destaca el uso de los modelos Mora-Vahrson y lógica difusa. Ecuador es un país tropical que ha sufrido varios desastres naturales, el último fue un deslizamiento sucedido en Alausí-Chimborazo donde murieron 65 personas; sin embargo, todavía persisten zonas poco estudiadas, como la región amazónica, la cual se presenta como caso de estudio al cantón Morona. El objetivo principal fue generar un modelo de susceptibilidad a deslizamientos mediante lógica difusa y Mora-Vahrson, y determinar el método que mejor se ajuste a su realidad geográfica. Los modelos resultantes fueron clasificados en cinco niveles de riesgo, donde el 80.73% de los deslizamientos registrados en zonas de alta y muy alta susceptibilidad fueron representados correctamente con lógica difusa, mientras que el 33.03% de precisión se obtuvo con Mora-Vahrson. El cotejamiento entre modelos determinó que las parroquias Macas, Alshi, Zúñac, San Isidro presentaron mayor susceptibilidad, pero con el modelamiento probabilístico difuso se logró identificar más detalladamente el nivel de riesgo a equipamientos presente en el territorio. Esta ventaja se debe a la escala de información cartográfica de las variables que son utilizadas en cada método, y que inciden en la precisión de los resultados, por lo que para fines de gestión de riesgos es recomendable utilizar metodologías como lógica difusa en trabajos a escalas ≥1:25000, en lugares similares a los que se analizó en este estudio, como son los territorios amazónicos del Ecuador
Historia de la Cartografía. La evolución de los mapas. El mundo medieval. De Bizancio al Renacimiento
Authors: Onesti Norberto Jorge
Published: May 2024

En palabras del autor en la Presentación (p. 15) de este segundo volumen de Historia de la Cartografía. La evolución de los mapas, es parte de la obra formado por tres volúmenes que recogen el Mundo Antiguo, el Mundo Medieval y el Mundo Moderno:  …el Mundo Medieval, que abarca el período comprendido desde la caída del Imperio Romano de Occidente hasta los albores del Renacimiento. La Historia se cerrará en el siglo XVII…
Presentación del Máster Universitario en Investigación Biomédica
Authors: Nieto González José Luis
Published: May 2024

El recurso consiste en una animación que presenta de manera detallada la estructura, contenido y proceso del Máster Universitario en Investigación Biomédica de la Universidad de Sevilla. Incluye información sobre los módulos del programa, objetivos y el proceso del Trabajo Fin de Máster (TFM). El recurso está diseñado para proporcionar información detallada sobre el Máster en Investigación Biomédica a estudiantes interesados, profesionales del ámbito biomédico, y personal académico involucrado en programas de educación superior en esta área. La animación proporciona una comprensión clara de la estructura y contenido del Máster en Investigación Biomédica, así como del proceso del TFM. Contribuye a la comprensión de la importancia de la investigación biomédica y cómo se aplica en un entorno educativo y profesional.
SPACE FOR FREE
Authors:   SPACE FOR FREE COLLECTIVE, Roberts Eira , Davidson Stephanie ,   SPACE FOR FREE COLLECTIVE
Published: May 2024

This presentation shares the inception of a new student-driven architecture publication, a poster-zine called SPACE FOR FREE. The zine is an outgrowth of a fourth year option studio course, which asks students to use walking and close observation as a main method in order to learn from existing spaces in our city – in this case, Toronto, Canada. More specifically, students are asked to identify spaces that are available for anyone to use,for any purpose, for free – without paying an admission or the need to patronize a business. The presentation and this project documentation are done by an instructor and student together, underscoring the process that the course tries to cultivate, of bottom-up learning, or quasi-collectivism. Students’ spatial discoveries in the city make-up the course content, and it is student experience that drives weekly discussion about urban space, and more specifically, “free” space.
Designing Out: A Framework for Studying Hostile Design
Authors:   University of Oregon, Kive Solmaz
Published: May 2024

The rising issue of homelessness has led to the deployment of hostile design aimed at discouraging unhoused individuals from using urban and public spaces. A wholistic approach to the problem must address architecture as a cause (not as merely an innocent reflection of an entirely independent problem). This paper provides a literature review of definitions and methods of analyzing hostile design. The growing literature on hostile design mainly focuses on the design strategies and their impact on the unhoused individuals, ignoring the majority, housed population under whose name hostile design is justified. I argue for expanding the study of hostile design to account for the subtle mechanisms of disgusting the true purpose of hostile design.
Innovation through Investigation: Creating a Cooperative Social Community
Authors:   Ferris State University, O'Connor Kate , Karst Makenna ,   University of Michigan
Published: May 2024

The community of Idlewild, located in Yates Township, Michigan, possesses a significant history as the largest historic African American resort community established during the Jim Crow Era. Established in 1912, it thrived for more than fifty years but declined with the passing of the Civil Rights Act in 1964. However, Idlewild has begun to revitalize, with new full-time residents seeking work-life balance in a rural context and, most importantly, residency in a safe community. However, Idlewild was originally designated for seasonal residents, resulting in a new set of needs for community sustainment.A special focus on research that engages with community visioning to develop planning that realigns community, township, and county goals for Idlewild is a significant driver in this exercise. The use of community visioning will be coupled with the township master planning process with focus on sustain-ability; the implementation of social solidarity economics, as well as open book management, will solidify the continued success of the community in the spirit of “co-opetition”. The application of these theories and their effect on the sustain-ability of Idlewild will be of particular interest. In addition to the environment, sustainability will include concern for people and economy to develop a balanced community structure. Social solidarity economic principles refer to a set of values and practices aimed at promoting economic systems that prioritize cooperation, social justice, and sustainability. It is an alternative model to the mainstream capitalist system and seeks to address the inequalities and environmental challenges created by traditional market economies. The principles of solidarity economy emphasize the well-being of individuals and communities over profit maximization. Key Principles that will be addressed in this paper are: 1. Solidarity and Cooperation 2. Social Justice and Equity 3. Democratic Governance 4. Sustainable Development5. Localization and Autonomy 6. Diverse Economic Forms 7. Ethical Consumption 8. Education and Awareness A critical factor in the planning process is preserving historical community values while not stifling progress that will allow for a continued longevity. Embracing the African American heritage of Idlewild makes this instance of cooperative community living a unique example, amplified by its resort identity. Extensive literature review, community engagement, and active group communication will serve as the basis for planning.The strategic conversation of the Idlewild community members will be formulated through the lens of social solidarity economic principles and community theory, leading to documentation of solutions for the future of Idlewild. The aspiration for this process is to create a successful case study for other rural communities to begin planning and applying cooperative community modeling.
Architectures of White Supremacy: Measuring Racism in College Campus Design
Authors:   University of Colorado Boulder, Randolph Aspen , Nicklas Chloe ,   University of Colorado Boulder, Roudbari Shawhin ,   University of Colorado Boulder
Published: May 2024

In her study of law schools in the US, sociologist Wendy Leo Moore identifies such academic institutions as hegemonic white spaces. Drawing upon the racist history of the legal system and the legal profession in the US, she shows that law schools are complicit in upholding white supremacist ideologies. In her study, Moore also noted the role that the architecture of law schools played in reproducing racism. In her analysis, she cites classroom seating layouts, symbolism in interior design, and alienating circulation through the building. Scholars of race and space offer powerful theoretical frameworks for understanding space’s role in perpetuating, inflicting, and creating racialized harms. But most do so by considering urban scales of space (e.g. the role of redlining or urban renewal). What is unique about Moore’s study of white spaces is her attention to architectural scales of space. In an effort to deepen this thread of inquiry, in this paper, the authors investigate how members of a university communityexperience white and racist spaces of a predominantly white campus. The authors conducted twenty participant-led go-alongs where participants guide walks through the campus spaces they navigate. Participants reported ways architectural elements such as material, spatial hierarchy, threshold, and framed views perpetuate white supremacy. This research aims to document ways that members of campus communities experience white supremacist architecture. The findings of this project contribute to theorizing ways white supremacy is reproduced at architectural scales of space.
“What to Build and Rebuild, Whom to Protect?”: Digital Technology, Climate Justice, and Housing Affordability
Authors:   Morgan State University, Sturlaugson Brent , Panthi Kamalesh ,   Morgan State University
Published: May 2024

The intersection of housing affordability, climate change, and social inequity in the mature years of the digital age raises a series of critical questions concerning the design professions. How can building designers adapt the urban environment to improve access to affordable housing? What opportunities exist for the integration of digital technologies throughout the design and construction process? How can these adaptations be applied in historic urban centers to reduce material consumption and preserve existing morphology? Most importantly, who benefits from these processes and how? In this paper, we address these questions by outlining a multiyear, interdisciplinary research and design project that uses Baltimore as a case study. While the specific nature of the built environment in Baltimore dictates much of the research and design process, the purpose of working with digital tools is to promote a wider application of our findings in broader and more diverse contexts. The project builds on a growing catalog of research regarding the integration of digital technology in the design professions, and while we aspire to contribute to this catalog with novel methods and new insights, our motivations remain guided by philosopherOlúfẹ́mi O. Táíwò’s critically important question, clearly articulated: “what to build and rebuild, whom to protect?”
IDEA Climate Justice Research: House 360 Prototypes
Authors:   Prairie View A&M University, Ward Jessica April
Published: May 2024

Architecture, Integrated Design for Environmental and Climate Justice Research (IDEA-CJR) aims to strengthen resilience in previously segregated and historically significant communities in the City of Houston most impacted by the compounded effects of environmental injustice over time. This regional disaster resilience research-based design studio in the Gulf Coast identified and addressed stakeholder needs through a regenerative, integrated design, service-learning approach (for the past 8 years). Resident homes in the Gulf Coast are disproportionately negatively impacted during extreme weather events. Fourth-year architecture students in the IDEA-CJR studio conducted qualitative and quantitative stakeholder need assessments during pre-design meetings with seniors aging in place during and after extreme weather events associated with; hurricanes, power grid failure, poor indoor air quality and flooding. Student designs of pocket communities with smart homes emerged from community- driven feedback, meetings with industry professionals in building performance and municipal leaders in Houston.