bluuebunny/crossref_metadata_2025 huggingface dataset:
Hypersensitive Reactions During Hemodialysis Treatment: What Do We Need to Know?
Authors: Afsar Baris , Afsar Rengin Elsurer
Published: March 2024

Kidney replacement therapies (KRTs) including hemodialysis (HD) are one of the treatment options for most of the patients with end‐stage kidney disease. Although HD is vital for these patients, it is not hundred percent physiological, and various adverse events including hypersensitivity reactions may occur. Fortunately, these reactions are rare in total and less when compared to previous decades, but it is still very important for at least two reasons: First, the number of patients receiving kidney replacement treatment is increasing globally; and the cumulative number of these reactions may be substantial. Second, although most of these reactions are mild, some of them may be very severe and even lead to mortality. Thus, it is very important to have basic knowledge and skills to diagnose and treat these reactions. Hypersensitivity reactions can occur at any component of dialysis machinery (access, extracorporeal circuit, medications, etc.). The most important preventive measure is to avoid the allergen. However, even with very specific test, sometimes the allergen cannot be found. In mild conditions, HD can be contained with non‐specific treatment (topical creams, antihistaminics, corticosteroids). In more severe conditions, treatment must be stopped immediately, blood should not be returned to patient, drugs must be stopped, and rules of general emergency treatment must be followed.
Full‐length sequence of the novel allele, HLA‐B*58:01:40, identified in a Chinese individual
Authors: Yang Fan , Peng Long , Gao Su‐Qing
Published: March 2024

HLA‐B*58:01:40 differs from HLA‐B*58:01:01 by a single nucleotide change in exon 3, 507 C‐ > T (codon 145.3 CGC‐ > CGT).
Four new intronic variants of HLA‐DQB1 detected by next‐generation sequencing
Authors: Marín Rubio Luis Alberto , Ontañón Jesús
Published: March 2024

Characterization of HLA‐DQB1*02:02:01:18, ‐DQB1*02:02:01:19, ‐DQB1*03:02:01:20 and ‐DQB1*05:03:01:10 alleles in Spanish individuals.
Genomic sequence of the novel HLA‐B*41:02:01:11, and ‐C*08:266 alleles identified in a solid organ recipient
Authors: Kouniaki Diamanto , Fotopoulos Konstantinos , Tsirogianni Alexandra
Published: March 2024

HLA‐B*41:02:01:11 and ‐C*08:266 were detected in a solid organ recipient during the HLA typing process.
‘I sound different, I look different, I am different’: Protecting and promoting the sense of authenticity of ethnically minoritised medical students
Authors: Moula Zoe , Zanting Albertine , Kumar Sonia
Published: March 2024

Background

Being authentic can improve students' well‐being and enhance the medical student–patient communication and patient safety. However, the underrepresentation of ethnically minoritised students in medical education can result in identity suppression, interfering with students' ability to succeed academically and professionally.

Methods

We conducted interviews with 20 ethnically minoritised medical students, which were analysed thematically, to explore the following:

What facilitates and prevents students from being their authentic self during medical school?

What learning and teaching strategies can enable students to be or become their authentic self?

Findings

Experiences of discrimination, microaggressions and/or racism were the main barriers to authenticity, leading to fear of being discriminated again if students expressed their true self. Lack of diversity, cultural awareness and staff representation were also fundamental barriers. Being authentic was often perceived as contradictory to being professional and a risk that could damage students' reputation. However, when students could express their true self, they felt happier, safer and developed a stronger sense of belonging.

Discussion

To enhance authenticity, students need to see better staff representation, role models they can relate and aspire to, such as Black professors. Equity/Diversity/Inclusion/Belonging (EDIB) training needs to become embedded throughout the curriculum and be delivered by facilitators with lived experiences. Other strategies to promote students' authenticity included mentoring, better signposting to complaints procedure and well‐being resources and implementation of ‘zero tolerance’ policies. To our knowledge, this is one of the first studies on the concept of authenticity in medical education and the first study focusing on ethnically minoritised students.
Occurrence of Amaranthus palmeri in Israeli agriculture: Status of spread and response to glyphosate and trifloxysulfuron
Authors: Abu‐Nassar Jackline , Wallach Amit , Winkler Eilon , Eizenberg Hanan , Matzrafi Maor
Published: March 2024

Amaranthus palmeri (Palmer Amaranth) is a dioecious annual weed species, originating from the Southern USA, spreading rapidly beyond its original range into Europe and the Mediterranean region. In Israel, A. palmeri distribution has expanded quickly in recent years, with farmers reporting on weed control failure using acetolactate synthase (ALS) inhibitors. Furthermore, recent studies have documented glyphosate‐resistant cases from other countries in the region, such as Spain, Greece and Turkey. We conducted a survey in order to understand A. palmeri distribution and study the occurrence of herbicide resistance to both glyphosate and trifloxysulfuron in different fields across the country. According to our data, A. palmeri population locations are aligned with the major agricultural areas for summer field crops, including the Hula Valley, Jezreel Valley and the Southern Coastal Plain. Regarding herbicide responses, while several populations showed a reduced response to glyphosate, dose–response assays did not show resistance to the recommended labelled field rate. For the ALS inhibitor trifloxysulfuron, the survival percentage was very high, especially in the southern coastline region (77%). Four populations used for dose–response studies were highly resistant, surviving at four times the recommended labelled field rate of trifloxysulfuron (30 g a.i. ha−1). Sequencing of the ALS gene, Trp574 to Leu alteration in resistant populations was recorded in all populations. The high level of resistance observed in this study, alongside the target‐site mutation found in populations of A. palmeri, endangers the future use of ALS inhibitors in corn, cotton, and other summer crops grown in Israel.
Coactivation in Symmetric Four-Bar Mechanisms Antagonistically Actuated by Cables
Authors: Muralidharan Vimalesh , Chevallereau Christine , Wenger Philippe
Published: March 2024

In biological systems, the joints are actuated antagonistically by muscles that can be moved coherently to achieve the desired displacement and coactivated with appropriate forces to vary joint stiffness. Inspired by this, there is an interest in developing bio-inspired robots suitable for low- and high-stiffness tasks. Mechanisms actuated by antagonist cables can be a reasonable approximation of biological joints. A study on the anti-parallelogram mechanism showed that the antagonistic forces (>0) positively influence its stiffness, similar to the biological joints. This work investigates more general symmetric four-bar mechanisms with crossed/non-crossed limbs and top and base bars of unequal lengths for this property. First, the cables are attached between the two unconnected pivot pairs in the four-bar mechanism, and their limits of movement are presented. Inside these limits, we show that the cable forces have a positive (resp. negative) influence on the stiffness of the mechanism when its limbs are crossed (resp. non-crossed). These results are validated experimentally in all cases. Subsequently, we consider alternate cable attachments for the mechanisms with non-crossed limbs to achieve coactivation. Examples show that coactivation is possible in these mechanisms but comes at the cost of a diminished range of movement. Among all the four-bar mechanisms considered, the anti-parallelogram mechanism offers the largest orientation range of (−π,π) for the top bar with respect to its base while providing coactivation and is thus the best choice.
Integrating Psychosocial Skill and Characteristic Development Into an English Academy Soccer Coaching Program: A Preliminary Investigation
Authors: Mitchell Tom O. , Cowburn Ian H.J. , Alder Dave B. , Till Kevin , Littlewood Martin A. , Cook Tony , Piggott David
Published: March 2024

This study aimed to assess the impact of a psychosocial development program on academy soccer players with coaches being central design and delivery. The 8 Pillars program (designed to foster Communication, Control, Commitment, Confidence, Concentration, Resilience, Presence, and Self-awareness) was delivered through player workshops, coaching practice, and coach-led environmental manipulation. A total of 25 academy soccer players (Mage 14.7 ± 0.3) completed the Psychological Characteristics of Development Excellence Questionnaire-2 pre- and postseason, and a self-report scale for each of the eight prescribed psychosocial skills and characteristics at five time points across the season. Significant (p < .05) improvement between pre- and postseason for “Imagery and Active Preparation,” “Seeking and Using Social Support,” and “Active Coping” factors within the Psychological Characteristics of Development Excellence Questionnaire-2 were evident. Significant (p < .05) improvements were shown for “Communication,” “Control,” “Commitment,” “Concentration,” and “Resilience” scales across the season. These findings give initial efficacy that a targeted, multifaceted program, largely delivered by coaches, can improve player self-reported psychosocial skills and characteristics in a U.K. academy soccer setting.
Draft genome sequence of halotolerant plant growth-promoting
Bacillus paralicheniformis
MHN12
Authors: Dahiya Priyanka , Kumar Pradeep , Rani Simran , Dang Amita Suneja , Suneja Pooja
Published: March 2024

Bacillus paralicheniformis
MHN12 possesses a 4,245,453-base pair genome with 45.9% G + C content, including 1 CRISPR, 80 tRNA, 8 rRNA genes, and 4,418 predicted coding sequences . MHN12 exhibits high salinity tolerance and plant growth-promoting abilities, making it a promising bioinoculant for enhancing plant growth in saline soils.
Copper and zinc isotopic compositions of methane-derived carbonates: Implications for paleo-methane seepage and paleoenvironmental proxies
Authors: Zhang Ganglan , Deng Yinan , Chen Fang , Li Ming , Cao Jun , Lai Hongfei , Zhu Yangtao , Yang Shengxiong , Liang Qianyong , Kuang Zenggui , Fang Yunxin , Liu Yufei , Jiang Xuexiao , Zhao Mingyu
Published: March 2024

Copper-zinc isotopic excursions in carbonate sedimentary successions are used to trace oceanic chemistry fluctuations that occurred in the geological past. However, whether carbonate sediments can accurately record the Cu-Zn isotopic compositions of coeval seawater is still a matter of debate. We analyzed the Cu-Zn isotopic compositions of well-characterized methane-derived carbonates from drill cores in the South China Sea to decode the effect of the sedimentary environment on Cu-Zn isotopic fractionation. All seep carbonates have uniform δ65Cuauth values (the per mil deviation of the 65Cu/63Cu ratio from the NIST 976 standard; −0.22‰ to 0‰) independent of the sedimentary environment. In contrast, the δ66Znauth values (the per mil deviation of the 66Zn/64Zn ratio from the JMC-Lyon standard) of seep carbonates that precipitated from bottom seawater (intense methane seepage; 0.59‰ to 1.03‰) are significantly higher than those that formed in pore-water environments (low methane flux; −0.07‰ to 0.41‰). This evidence implies that changes in sedimentary environments can affect the Zn isotopic fractionation of carbonate sediments. Furthermore, the strong sedimentary environment-dependent Zn isotopic fractionation proves the validity of using Zn isotopes as a robust proxy for tracing paleo-methane seepage intensity caused by gas hydrate dissociation.
Traditional polar transportation seen from within the culture
Authors: Mustonen Tero
Published: March 2024

This paper explores cultural narratives and oral histories related to two examples of traditional northern transport—long seal hunting journeys in the Baltic region and nomadic reindeer travel in northeastern Siberia. Ample material has been collected and reviewed regarding means of nonmotorised transport in the polar regions. However, scientific literature concerning the experiences and perspectives of the Indigenous and traditional community members who took part in these journeys remains scarce. This article explores the recorded narratives of two people involved in the journeys described. It assesses how these long-distance travels form significance, meaning, observations, and belonging to landscapes for these people. This analysis reveals that, rather than inhabiting northern ice and tundra scapes that are often described as barren and devoid of life, seal hunters and reindeer herders live in story-scapes rich in meaning. The sacred places, surrender to ice flow dynamics, and ways of living “inside” northern habitats that emerge from these testimonies offer a skeleton key for re-reading the misunderstood homelands of Arctic and tundra communities.
Gravitational perturbation in nonlocal modified Tolman VII model
Authors: Jayawiguna Byon N. , Burikham Piyabut
Published: March 2024

In comparison to the original Tolman VII model, Exact Modified Tolman VII (EMTVII) with one additional parameter can increase the compactness of compact object. When the compactness is in the ultracompact regime, the quasinormal modes (QNMs) of the trapped mode as well as the gravitational echoes become more viable. Starting with the EMTVII model, we introduce nonlocality into the matter sector and analyze the effective potential, the QNMs, and the gravitational echoes of the compact and ultracompact object in the nonlocal model. The nonlocal gravity version of EMTVII (NEMTVII) is parametrized by the nonlocal parameter ($$ \beta $$
β
), modified Tolman VII parameter ($$ \alpha $$
α
), and the compactness ($$ {\mathcal {C}}$$
C
). It is found that the nonlocal profile produces the smeared surface and consequently reduce the compactness. The maximum compactness $${\mathcal {C}}_{max}=0.4$$

C

max

=
0.4

occurs when $$\alpha =0=\beta $$

α
=
0
=
β

, i.e., EMTVII with no smearing. For relatively small value of $$\beta = 0.01$$

β
=
0.01

and the compactness $$ {\mathcal {C}} \lesssim 0.2667$$

C
≲
0.2667

 (with $$M=2.14$$

M
=
2.14

solar masses, $$R=11.835$$

R
=
11.835

km at $$\alpha =1.4$$

α
=
1.4

), the causality condition and the dominant energy condition (DEC) are satisfied. The quasinormal modes of the gravitational perturbation are calculated using Bohr-Sommerfeld (BS) fitting and we find that the nonlocality produces less trapped modes than the original (EMTVII) counterpart. At high compactness, gravitational echoes are simulated numerically. Echoes are found to exist in the parameter space where the dominant energy condition and the causality condition are violated.
Virtual Power Grid Flux-Oriented Vector Control for Three-Phase Voltage-Type PWM Rectifier
Authors: Hu Xiaowei
Published: March 2024

More considerable power distortions are produced by the non-reversible diode-bridge rectifiers in the power system’s AC-DC conversion technology. In addition, bridge-rectifiers worsen energy quality and decrease power factor. Three-Phase Pulse Width Modulation (3phase-PWM) rectifiers have seen rapid growth in use due to recent breakthroughs in power device technology. Its benefits include a unity power factor, no harmonic distortion, and pulsating direct currents. An actual power regulation technique based on a novel virtual power grid controller is suggested to cheaply regulate a 3phase-PWM converter with good performance. The study introduces a new sensorless control scheme to improve the 3phase-PWM-performance rectifier. The proposed control technique employs the virtual power grid flux-oriented vector control with a Second-Order Generic Integral with Instantaneous Phase Lock Loop (SOGI-IPLL) to overcome the problems inherent in relying only on low-pass filter estimates. The virtual power grid flux value may then determine the phase difference. The IPLL takes the phase angle as an input and is utilized to construct the power-oriented vector control. The proposed power grid flux-oriented control strategy combines the VFidea with SOGI-IPLL to circumvent the restrictions imposed by relying only on an integrator of low-pass filters (LPF) to provide an estimate. A refined Virtual flux (VF) estimator with direct power control can improve management at a cheaper cost and more efficiently. The modeling findings demonstrate that the DC voltage input and power grid throughput of the 3phase-PWM rectifier can be successfully regulated in both the rectification and inversion states, allowing for the effective functioning of the 3phase-PWM rectifier.
Inaugural Issue of the International Journal of Artificial Intelligence and Robotics Research (IJAIRR): The Emergence of an Interdisciplinary Nexus
Authors: Sun Yu , Xu Dong , Zhu Xiaorui
Published: March 2024

For the inaugural issue of the International Journal of Artificial Intelligence and Robotics Research (IJAIRR), I am honored to present an editorial that encapsulates the essence and ambition of this cutting-edge publication. IJAIRR emerges at a time when Artificial Intelligence and Robotics (AIR) are not merely technological novelties but fundamental drivers of progress across various scientific and practical domains. This journal aims to be at the forefront of documenting, analyzing, and guiding the interdisciplinary integration of AI, robotics, and fundamental sciences.
Pangenome Analysis of Helicobacter pylori Isolates from Selected Areas of Africa Indicated Diverse Antibiotic Resistance and Virulence Genes
Authors: Yakubu Biigba , Appiah Edwin Moses , Adu Andrews Frimpong
Published: March 2024

The challenge facing Helicobacter pylori (H. pylori) infection management in some parts of Africa is the evolution of drug-resistant species, the lack of gold standard in diagnostic methods, and the ineffectiveness of current vaccines against the bacteria. It is being established that even though clinical consequences linked to the bacteria vary geographically, there is rather a generic approach to treatment. This situation has remained problematic in the successful fight against the bacteria in parts of Africa. As a result, this study compared the genomes of selected H. pylori isolates from selected areas of Africa and evaluated their virulence and antibiotic drug resistance, those that are highly pathogenic and are associated with specific clinical outcomes and those that are less virulent and rarely associated with clinical outcomes. 146 genomes of H. pylori isolated from selected locations of Africa were sampled, and bioinformatic tools such as Abricate, CARD RGI, MLST, Prokka, Roary, Phandango, Google Sheets, and iTOLS were used to compare the isolates and their antibiotic resistance or susceptibility. Over 20 k virulence and AMR genes were observed. About 95% of the isolates were genetically diverse, 90% of the isolates harbored shell genes, and 50% harbored cloud and core genes. Some isolates did not retain the cagA and vacA genes. Clarithromycin, metronidazole, amoxicillin, and tinidazole were resistant to most AMR genes (vacA, cagA, oip, and bab). Conclusion. This study found both virulence and AMR genes in all H. pylori strains in all the selected geographies around Africa with differing quantities. MLST, Pangenome, and ORF analyses showed disparities among the isolates. This in general could imply diversities in terms of genetics, evolution, and protein production. Therefore, generic administration of antibiotics such as clarithromycin, amoxicillin, and erythromycin as treatment methods in the African subregion could be contributing to the spread of the bacterium’s antibiotic resistance.
High Prevalence of A−β+ Ketosis-Prone Diabetes in Children with Type 2 Diabetes and Diabetic Ketoacidosis at Diagnosis: Evidence from the Rare and Atypical Diabetes Network (RADIANT)
Authors: Kubota-Mishra Elizabeth , Huang Xiaofan , Minard Charles G. , Astudillo Marcela , Refaey Ahmad , Montes Graciela , Sisley Stephanie , Ram Nalini , Winter William E. , Naylor Rochelle N. , Balasubramanyam Ashok , Redondo Maria J. , Tosur Mustafa ,   RADIANT Study Group
Published: March 2024

Background. A−β+ ketosis-prone diabetes (KPD) in adults is characterized by presentation with diabetic ketoacidosis (DKA), negative islet autoantibodies, and preserved β-cell function in persons with a phenotype of obesity-associated type 2 diabetes (T2D). The prevalence of KPD has not been evaluated in children. We investigated children with DKA at “T2D” onset and determined the prevalence and characteristics of pediatric A−β+ KPD within this cohort. Methods. We reviewed the records of 716 children with T2D at a large academic hospital and compared clinical characteristics of those with and without DKA at onset. In the latter group, we identified patients with A−β+ KPD using criteria of the Rare and Atypical Diabetes Network (RADIANT) and defined its prevalence and characteristics. Results. Mean age at diagnosis was 13.7 ± 2.4 years: 63% female; 59% Hispanic, 29% African American, 9% non-Hispanic White, and 3% other. Fifty-six (7.8%) presented with DKA at diagnosis and lacked islet autoantibodies. Children presenting with DKA were older and had lower C-peptide and higher glucose concentrations than those without DKA. Twenty-five children with DKA (45%) met RADIANT A−β+ KPD criteria. They were predominantly male (64%), African American or Hispanic (96%), with substantial C-peptide (1.3 ± 0.7 ng/mL) at presentation with DKA and excellent long-term glycemic control (HbA1c 6.6% ± 1.9% at follow-up (median 1.3 years postdiagnosis)). Conclusions. In children with a clinical phenotype of T2D and DKA at diagnosis, approximately half meet criteria for A−β+ KPD. They manifest the key characteristics of obesity, preserved β-cell function, male predominance, and potential to discontinue insulin therapy, similar to adults with A−β+ KPD.
Prevalence and Factors Associated with Iron Deficiency Anaemia among Children Aged 6-23 Months in Southwestern Uganda
Authors: Kajoba Dickson , Egesa Walufu Ivan , Muyombya Solomon , Ortiz Yamile Arias , Nduwimana Martin , Ndeezi Grace
Published: March 2024

Iron deficiency anaemia is still a global public health concern with the highest burden among children 6 to 23 months due to their rapid growth spurt exceeding breastmilk supply. Therefore, nutritional supply is a key source of iron to attain the required nutrients for better growth and development. This was a cross-sectional descriptive study done at Ishaka Adventist Hospital (IAH) and Kampala International University Teaching Hospital (KIUTH) from April to July 2022. Participants were consecutively enrolled in the study. Structured questionnaires, 24-hour dietary recall, and clinical assessment were used to obtain data. Data analysis was done using the statistical package for social scientists (SPSS) V22.0. Bivariable and multivariable analyses were done using logistic regression for associations with significance set at P value < 0.05. A total of 364 participants were enrolled, with the majority being males (198, 54.4%) and born at term (333, 91.5%). The modal age was 12-17 months [163(44.8%)] with a mean age of 14.1 months (SD 5.32). The overall prevalence of IDA was 151/364 (41.5%). The factors associated with IDA included male sex (aOR 1.61), current episode of diarrhoea (aOR 1.71), poor meal frequency (aOR 1.78), no vegetable consumption (aOR 2.47), and consuming fruits once (aOR 1.97) in 7 days preceding the study. The study finds a high prevalence of IDA among infants 6-23 months with at least four in 10 being affected. Screening for IDA should be recommended in male children with current diarrhoea, poor intake of fruits and vegetables, and poor meal frequency. The Mentzer index is an equally good alternative screening test for IDA.
Supplementary Data from Body Weight Correlates with Molecular Variances in Patients with Cancer
Authors: Huang Fengyuan , Xu Peng , Yue Zongliang , Song Yuwei , Hu Kaili , Zhao Xinyang , Gao Min , Chong Zechen
Published: March 2024

Supplementary Figures and Tables
Supplementary tables from AXL/WRNIP1 Mediates Replication Stress Response and Promotes Therapy Resistance and Metachronous Metastasis in HER2+ Breast Cancer
Authors: Marquez-Palencia Mauricio , Reza Herrera Luis , Parida Pravat Kumar , Ghosh Suvranil , Kim Kangsan , Das Nikitha M. , Gonzalez-Ericsson Paula I. , Sanders Melinda E. , Mobley Bret C. , Diegeler Sebastian , Aguilera Todd A. , Peng Yan , Lewis Cheryl M. , Arteaga Carlos L. , Hanker Ariella B. , Whitehurst Angelique W. , Lorens James B. , Brekken Rolf A. , Davis Anthony J. , Malladi Srinivas
Published: March 2024

Supplementary tables 1 and 2
Supplementary Figure and figure legends from DNA-PK–Mediated Cytoplasmic DNA Sensing Stimulates Glycolysis to Promote Lung Squamous Cell Carcinoma Malignancy and Chemoresistance
Authors: Wang Hui , Zhang Yanyang , Tian Yu , Yang Wanlin , Wang Yan , Hou Hui , Pan Hanbo , Pei Siyu , Zhu Hongda , Gu Zenan , Zhang Yanyun , Dai Dongfang , Chen Wei , Zheng Mingyue , Luo Qingquan , Xiao Yichuan , Huang Jia
Published: March 2024

Supplementary Figure and figure legends
Supplementary Data from Chronic Stress Dampens Lactobacillus Johnsonii–Mediated Tumor Suppression to Enhance Colorectal Cancer Progression
Authors: Cao Qiuhua , Zhao Mingrui , Su Yali , Liu Siliang , Lin Yanting , Da Huijuan , Yue Chongxiu , Liu Yiming , Jing Dongquan , Zhao Qixiang , Liu Ning , Du Juan , Zuo Zhanjie , Fu Yao , Chen Anqi , Birnbaumer Lutz , Yang Yong , Dai Beiying , Gao Xinghua
Published: March 2024

Supplementary Materials and Methods.
Supplementary Data from Chronic Stress Dampens Lactobacillus Johnsonii–Mediated Tumor Suppression to Enhance Colorectal Cancer Progression
Authors: Cao Qiuhua , Zhao Mingrui , Su Yali , Liu Siliang , Lin Yanting , Da Huijuan , Yue Chongxiu , Liu Yiming , Jing Dongquan , Zhao Qixiang , Liu Ning , Du Juan , Zuo Zhanjie , Fu Yao , Chen Anqi , Birnbaumer Lutz , Yang Yong , Dai Beiying , Gao Xinghua
Published: March 2024

Figure S4
Supplementary Data from Chronic Stress Dampens Lactobacillus Johnsonii–Mediated Tumor Suppression to Enhance Colorectal Cancer Progression
Authors: Cao Qiuhua , Zhao Mingrui , Su Yali , Liu Siliang , Lin Yanting , Da Huijuan , Yue Chongxiu , Liu Yiming , Jing Dongquan , Zhao Qixiang , Liu Ning , Du Juan , Zuo Zhanjie , Fu Yao , Chen Anqi , Birnbaumer Lutz , Yang Yong , Dai Beiying , Gao Xinghua
Published: March 2024

Figure S5
Supplementary Figures S1-S28 from Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity
Authors: Awad Dominik , Cao Pham Hong Anh , Pulliam Thomas L. , Spradlin Meredith , Subramani Elavarasan , Tellman Tristen V. , Ribeiro Caroline F. , Muzzioli Riccardo , Jewell Brittany E. , Pakula Hubert , Ackroyd Jeffrey J. , Murray Mollianne M. , Han Jenny J. , Leng Mei , Jain Antrix , Piyarathna Badrajee , Liu Jingjing , Song Xingzhi , Zhang Jianhua , Klekers Albert R. , Drake Justin M. , Ittmann Michael M. , Coarfa Cristian , Piwnica-Worms David , Farach-Carson Mary C. , Loda Massimo , Eberlin Livia S. , Frigo Daniel E.
Published: March 2024

28 supplementary figures supporting the main text and main figures.
Supplementary Data from Chronic Stress Dampens Lactobacillus Johnsonii–Mediated Tumor Suppression to Enhance Colorectal Cancer Progression
Authors: Cao Qiuhua , Zhao Mingrui , Su Yali , Liu Siliang , Lin Yanting , Da Huijuan , Yue Chongxiu , Liu Yiming , Jing Dongquan , Zhao Qixiang , Liu Ning , Du Juan , Zuo Zhanjie , Fu Yao , Chen Anqi , Birnbaumer Lutz , Yang Yong , Dai Beiying , Gao Xinghua
Published: March 2024

Figure S7
Supplementary Data from Chronic Stress Dampens Lactobacillus Johnsonii–Mediated Tumor Suppression to Enhance Colorectal Cancer Progression
Authors: Cao Qiuhua , Zhao Mingrui , Su Yali , Liu Siliang , Lin Yanting , Da Huijuan , Yue Chongxiu , Liu Yiming , Jing Dongquan , Zhao Qixiang , Liu Ning , Du Juan , Zuo Zhanjie , Fu Yao , Chen Anqi , Birnbaumer Lutz , Yang Yong , Dai Beiying , Gao Xinghua
Published: March 2024

Supplementary Table.
Figure S1 from Lysine Deacetylation Is a Key Function of the Lysyl Oxidase Family of Proteins in Cancer
Authors: Wu Xingxing , Li Xue , Wang Luwei , Bi Xianxia , Zhong Weihong , Yue Jicheng , Chin Y. Eugene
Published: March 2024

Subcellular distribution of proteins harboring LOXL2-catalyzed deacetylation sites. Gene Ontology (GO) annotation proteome was derived from the UniProt-GOA database. The proteins were classified by Gene Ontology annotation based on cellular component.
Table S2 from The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen
Authors: Malta Tathiane M. , Sabedot Thais S. , Morosini Natalia S. , Datta Indrani , Garofano Luciano , Vallentgoed Wies , Varn Frederick S. , Aldape Kenneth , D'Angelo Fulvio , Bakas Spyridon , Barnholtz-Sloan Jill S. , Gan Hui K. , Hasanain Mohammad , Hau Ann-Christin , Johnson Kevin C. , Cazacu Simona , deCarvalho Ana C. , Khasraw Mustafa , Kocakavuk Emre , Kouwenhoven Mathilde C.M. , Migliozzi Simona , Niclou Simone P. , Niers Johanna M. , Ormond D. Ryan , Paek Sun Ha , Reifenberger Guido , Sillevis Smitt Peter A. , Smits Marion , Stead Lucy F. , van den Bent Martin J. , Van Meir Erwin G. , Walenkamp Annemiek , Weiss Tobias , Weller Michael , Westerman Bart A. , Ylstra Bauke , Wesseling Pieter , Lasorella Anna , French Pim J. , Poisson Laila M. , Woehrer Adelheid , Lowman Allison K , deCarvalho Ana C , Castro Ana Valeria , Transou Andrea , Brodbelt Andrew R , Hau Ann-Christin , Lasorella Anna , Golebiewska Anna , Walenkamp Annemiek , Molinaro Annette M , Iavarone Antonio , Ismail Azzam , Westerman Bart A , Ylstra Bauke , Bock Christoph , Ormond D. Ryan , Brat Daniel J , Kocakavuk Emre , Van Meir Erwin G , Barthel Floris P , Varn Frederick S , D'Angelo Fulvio , Finocchiaro Gaetano , Rao Ganesh , Zadeh Gelareh , Reifenberger Guido , ngNg Ho Keu , Kim Hoon , Noushmehr Houtan , Miletic Hrvoje , Gan Hui K , Datta Indrani , Rock Jack , Snyder James M , Huse Jason T , Connelly Jennifer M , Barnholtz-Sloan Jill S , Niers Johanna M , deGroot John F , Akdemir Kadir C , Kannan Kasthuri S , Ligon Keith L , Aldape Kenneth , Bulsara Ketan R , Johnson Kevin C , Alfaro Kristin D , Poisson Laila M , Garofano Luciano , Stead Lucy F , Nasrallah MacLean P , Smits Marion , van den Bent Martin J , Kouwenhoven Mathilde CM , Weller Michael , Hasanain Mohammad , Khasraw Mustafa , Gould Peter V , Smitt Peter A Sillevis , LaViolette Peter S , Tatman Philip D , Wesseling Pieter , French Pim J , Beroukhim Rameen , Verhaak Roel G.W. , Migliozzi Simona , Niclou Simone P , Bakas Spyridon , Kalkanis Steven , Paek Sun Ha , Short Susan C , Ghazaleh Tabatabai , Malta Tathiane M , Sabedot Thais S , Weiss Tobias , Walbert Tobias , Baid Ujjwal , Vallentgoed Wies , Yung W. K. Alfred , Verhaak Roel G.W. , Iavarone Antonio , Noushmehr Houtan
Published: March 2024

Table S2: List of 132 pairs (ID of Initial and Recurrent samples)
Table S1 from The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen
Authors: Malta Tathiane M. , Sabedot Thais S. , Morosini Natalia S. , Datta Indrani , Garofano Luciano , Vallentgoed Wies , Varn Frederick S. , Aldape Kenneth , D'Angelo Fulvio , Bakas Spyridon , Barnholtz-Sloan Jill S. , Gan Hui K. , Hasanain Mohammad , Hau Ann-Christin , Johnson Kevin C. , Cazacu Simona , deCarvalho Ana C. , Khasraw Mustafa , Kocakavuk Emre , Kouwenhoven Mathilde C.M. , Migliozzi Simona , Niclou Simone P. , Niers Johanna M. , Ormond D. Ryan , Paek Sun Ha , Reifenberger Guido , Sillevis Smitt Peter A. , Smits Marion , Stead Lucy F. , van den Bent Martin J. , Van Meir Erwin G. , Walenkamp Annemiek , Weiss Tobias , Weller Michael , Westerman Bart A. , Ylstra Bauke , Wesseling Pieter , Lasorella Anna , French Pim J. , Poisson Laila M. , Woehrer Adelheid , Lowman Allison K , deCarvalho Ana C , Castro Ana Valeria , Transou Andrea , Brodbelt Andrew R , Hau Ann-Christin , Lasorella Anna , Golebiewska Anna , Walenkamp Annemiek , Molinaro Annette M , Iavarone Antonio , Ismail Azzam , Westerman Bart A , Ylstra Bauke , Bock Christoph , Ormond D. Ryan , Brat Daniel J , Kocakavuk Emre , Van Meir Erwin G , Barthel Floris P , Varn Frederick S , D'Angelo Fulvio , Finocchiaro Gaetano , Rao Ganesh , Zadeh Gelareh , Reifenberger Guido , ngNg Ho Keu , Kim Hoon , Noushmehr Houtan , Miletic Hrvoje , Gan Hui K , Datta Indrani , Rock Jack , Snyder James M , Huse Jason T , Connelly Jennifer M , Barnholtz-Sloan Jill S , Niers Johanna M , deGroot John F , Akdemir Kadir C , Kannan Kasthuri S , Ligon Keith L , Aldape Kenneth , Bulsara Ketan R , Johnson Kevin C , Alfaro Kristin D , Poisson Laila M , Garofano Luciano , Stead Lucy F , Nasrallah MacLean P , Smits Marion , van den Bent Martin J , Kouwenhoven Mathilde CM , Weller Michael , Hasanain Mohammad , Khasraw Mustafa , Gould Peter V , Smitt Peter A Sillevis , LaViolette Peter S , Tatman Philip D , Wesseling Pieter , French Pim J , Beroukhim Rameen , Verhaak Roel G.W. , Migliozzi Simona , Niclou Simone P , Bakas Spyridon , Kalkanis Steven , Paek Sun Ha , Short Susan C , Ghazaleh Tabatabai , Malta Tathiane M , Sabedot Thais S , Weiss Tobias , Walbert Tobias , Baid Ujjwal , Vallentgoed Wies , Yung W. K. Alfred , Verhaak Roel G.W. , Iavarone Antonio , Noushmehr Houtan
Published: March 2024

Table S1: GLASS surgery-level clinical and molecular characteristics (N=354)
Supplemental Figures Legends from The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen
Authors: Malta Tathiane M. , Sabedot Thais S. , Morosini Natalia S. , Datta Indrani , Garofano Luciano , Vallentgoed Wies , Varn Frederick S. , Aldape Kenneth , D'Angelo Fulvio , Bakas Spyridon , Barnholtz-Sloan Jill S. , Gan Hui K. , Hasanain Mohammad , Hau Ann-Christin , Johnson Kevin C. , Cazacu Simona , deCarvalho Ana C. , Khasraw Mustafa , Kocakavuk Emre , Kouwenhoven Mathilde C.M. , Migliozzi Simona , Niclou Simone P. , Niers Johanna M. , Ormond D. Ryan , Paek Sun Ha , Reifenberger Guido , Sillevis Smitt Peter A. , Smits Marion , Stead Lucy F. , van den Bent Martin J. , Van Meir Erwin G. , Walenkamp Annemiek , Weiss Tobias , Weller Michael , Westerman Bart A. , Ylstra Bauke , Wesseling Pieter , Lasorella Anna , French Pim J. , Poisson Laila M. , Woehrer Adelheid , Lowman Allison K , deCarvalho Ana C , Castro Ana Valeria , Transou Andrea , Brodbelt Andrew R , Hau Ann-Christin , Lasorella Anna , Golebiewska Anna , Walenkamp Annemiek , Molinaro Annette M , Iavarone Antonio , Ismail Azzam , Westerman Bart A , Ylstra Bauke , Bock Christoph , Ormond D. Ryan , Brat Daniel J , Kocakavuk Emre , Van Meir Erwin G , Barthel Floris P , Varn Frederick S , D'Angelo Fulvio , Finocchiaro Gaetano , Rao Ganesh , Zadeh Gelareh , Reifenberger Guido , ngNg Ho Keu , Kim Hoon , Noushmehr Houtan , Miletic Hrvoje , Gan Hui K , Datta Indrani , Rock Jack , Snyder James M , Huse Jason T , Connelly Jennifer M , Barnholtz-Sloan Jill S , Niers Johanna M , deGroot John F , Akdemir Kadir C , Kannan Kasthuri S , Ligon Keith L , Aldape Kenneth , Bulsara Ketan R , Johnson Kevin C , Alfaro Kristin D , Poisson Laila M , Garofano Luciano , Stead Lucy F , Nasrallah MacLean P , Smits Marion , van den Bent Martin J , Kouwenhoven Mathilde CM , Weller Michael , Hasanain Mohammad , Khasraw Mustafa , Gould Peter V , Smitt Peter A Sillevis , LaViolette Peter S , Tatman Philip D , Wesseling Pieter , French Pim J , Beroukhim Rameen , Verhaak Roel G.W. , Migliozzi Simona , Niclou Simone P , Bakas Spyridon , Kalkanis Steven , Paek Sun Ha , Short Susan C , Ghazaleh Tabatabai , Malta Tathiane M , Sabedot Thais S , Weiss Tobias , Walbert Tobias , Baid Ujjwal , Vallentgoed Wies , Yung W. K. Alfred , Verhaak Roel G.W. , Iavarone Antonio , Noushmehr Houtan
Published: March 2024

Supplemental Figures Legends
Supp Figures from The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen
Authors: Malta Tathiane M. , Sabedot Thais S. , Morosini Natalia S. , Datta Indrani , Garofano Luciano , Vallentgoed Wies , Varn Frederick S. , Aldape Kenneth , D'Angelo Fulvio , Bakas Spyridon , Barnholtz-Sloan Jill S. , Gan Hui K. , Hasanain Mohammad , Hau Ann-Christin , Johnson Kevin C. , Cazacu Simona , deCarvalho Ana C. , Khasraw Mustafa , Kocakavuk Emre , Kouwenhoven Mathilde C.M. , Migliozzi Simona , Niclou Simone P. , Niers Johanna M. , Ormond D. Ryan , Paek Sun Ha , Reifenberger Guido , Sillevis Smitt Peter A. , Smits Marion , Stead Lucy F. , van den Bent Martin J. , Van Meir Erwin G. , Walenkamp Annemiek , Weiss Tobias , Weller Michael , Westerman Bart A. , Ylstra Bauke , Wesseling Pieter , Lasorella Anna , French Pim J. , Poisson Laila M. , Woehrer Adelheid , Lowman Allison K , deCarvalho Ana C , Castro Ana Valeria , Transou Andrea , Brodbelt Andrew R , Hau Ann-Christin , Lasorella Anna , Golebiewska Anna , Walenkamp Annemiek , Molinaro Annette M , Iavarone Antonio , Ismail Azzam , Westerman Bart A , Ylstra Bauke , Bock Christoph , Ormond D. Ryan , Brat Daniel J , Kocakavuk Emre , Van Meir Erwin G , Barthel Floris P , Varn Frederick S , D'Angelo Fulvio , Finocchiaro Gaetano , Rao Ganesh , Zadeh Gelareh , Reifenberger Guido , ngNg Ho Keu , Kim Hoon , Noushmehr Houtan , Miletic Hrvoje , Gan Hui K , Datta Indrani , Rock Jack , Snyder James M , Huse Jason T , Connelly Jennifer M , Barnholtz-Sloan Jill S , Niers Johanna M , deGroot John F , Akdemir Kadir C , Kannan Kasthuri S , Ligon Keith L , Aldape Kenneth , Bulsara Ketan R , Johnson Kevin C , Alfaro Kristin D , Poisson Laila M , Garofano Luciano , Stead Lucy F , Nasrallah MacLean P , Smits Marion , van den Bent Martin J , Kouwenhoven Mathilde CM , Weller Michael , Hasanain Mohammad , Khasraw Mustafa , Gould Peter V , Smitt Peter A Sillevis , LaViolette Peter S , Tatman Philip D , Wesseling Pieter , French Pim J , Beroukhim Rameen , Verhaak Roel G.W. , Migliozzi Simona , Niclou Simone P , Bakas Spyridon , Kalkanis Steven , Paek Sun Ha , Short Susan C , Ghazaleh Tabatabai , Malta Tathiane M , Sabedot Thais S , Weiss Tobias , Walbert Tobias , Baid Ujjwal , Vallentgoed Wies , Yung W. K. Alfred , Verhaak Roel G.W. , Iavarone Antonio , Noushmehr Houtan
Published: March 2024

Supp Figures
Supplementary Figure4 from Adipocyte Precursor-Derived NRG1 Promotes Resistance to FGFR Inhibition in Urothelial Carcinoma
Authors: Hosni Sana , Kilian Viola , Klümper Niklas , Gabbia Daniela , Sieckmann Katharina , Corvino Dillon , Winkler Anja , Saponaro Miriam , Wörsdörfer Karin , Schmidt Doris , Hahn Oliver , Zanotto Ilaria , Bertlich Marina , Toma Marieta , Bald Tobias , Eckstein Markus , Hölzel Michael , Geyer Matthias , Ritter Manuel , Wachten Dagmar , De Martin Sara , Alajati Abdullah
Published: March 2024

Supplementary Figure4
Supplementary Figure1 from Adipocyte Precursor-Derived NRG1 Promotes Resistance to FGFR Inhibition in Urothelial Carcinoma
Authors: Hosni Sana , Kilian Viola , Klümper Niklas , Gabbia Daniela , Sieckmann Katharina , Corvino Dillon , Winkler Anja , Saponaro Miriam , Wörsdörfer Karin , Schmidt Doris , Hahn Oliver , Zanotto Ilaria , Bertlich Marina , Toma Marieta , Bald Tobias , Eckstein Markus , Hölzel Michael , Geyer Matthias , Ritter Manuel , Wachten Dagmar , De Martin Sara , Alajati Abdullah
Published: March 2024

Supplementary Figure1
Data from AXL/WRNIP1 Mediates Replication Stress Response and Promotes Therapy Resistance and Metachronous Metastasis in HER2+ Breast Cancer
Authors: Marquez-Palencia Mauricio , Reza Herrera Luis , Parida Pravat Kumar , Ghosh Suvranil , Kim Kangsan , Das Nikitha M. , Gonzalez-Ericsson Paula I. , Sanders Melinda E. , Mobley Bret C. , Diegeler Sebastian , Aguilera Todd A. , Peng Yan , Lewis Cheryl M. , Arteaga Carlos L. , Hanker Ariella B. , Whitehurst Angelique W. , Lorens James B. , Brekken Rolf A. , Davis Anthony J. , Malladi Srinivas
Published: March 2024

Abstract
Therapy resistance and metastatic progression are primary causes of cancer-related mortality. Disseminated tumor cells possess adaptive traits that enable them to reprogram their metabolism, maintain stemness, and resist cell death, facilitating their persistence to drive recurrence. The survival of disseminated tumor cells also depends on their ability to modulate replication stress in response to therapy while colonizing inhospitable microenvironments. In this study, we discovered that the nuclear translocation of AXL, a TAM receptor tyrosine kinase, and its interaction with WRNIP1, a DNA replication stress response factor, promotes the survival of HER2+ breast cancer cells that are resistant to HER2-targeted therapy and metastasize to the brain. In preclinical models, knocking down or pharmacologically inhibiting AXL or WRNIP1 attenuated protection of stalled replication forks. Furthermore, deficiency or inhibition of AXL and WRNIP1 also prolonged metastatic latency and delayed relapse. Together, these findings suggest that targeting the replication stress response, which is a shared adaptive mechanism in therapy-resistant and metastasis-initiating cells, could reduce metachronous metastasis and enhance the response to standard-of-care therapies.
Significance:
Nuclear AXL and WRNIP1 interact and mediate replication stress response, promote therapy resistance, and support metastatic progression, indicating that targeting the AXL/WRNIP1 axis is a potentially viable therapeutic strategy for breast cancer.
Data from Pooled CRISPR Screening Identifies P-Bodies as Repressors of Cancer Epithelial–Mesenchymal Transition
Authors: Fang Liang , Zhang Li , Wang Mengran , He Yuhao , Yang Jiao , Huang Zengjin , Tan Ying , Fang Ke , Li Jun , Sun Zhiyuan , Li Yanping , Tang Yisen , Liang Weizheng , Cui Huanhuan , Zhu Qionghua , Wu Zhe , Li Yiming , Hu Yuhui , Chen Wei
Published: March 2024

Abstract
Epithelial–mesenchymal transition (EMT) is a fundamental cellular process frequently hijacked by cancer cells to promote tumor progression, especially metastasis. EMT is orchestrated by a complex molecular network acting at different layers of gene regulation. In addition to transcriptional regulation, posttranscriptional mechanisms may also play a role in EMT. Here, we performed a pooled CRISPR screen analyzing the influence of 1,547 RNA-binding proteins on cell motility in colon cancer cells and identified multiple core components of P-bodies (PB) as negative modulators of cancer cell migration. Further experiments demonstrated that PB depletion by silencing DDX6 or EDC4 could activate hallmarks of EMT thereby enhancing cell migration in vitro as well as metastasis formation in vivo. Integrative multiomics analysis revealed that PBs could repress the translation of the EMT driver gene HMGA2, which contributed to PB-meditated regulation of EMT. This mechanism is conserved in other cancer types. Furthermore, endoplasmic reticulum stress was an intrinsic signal that induced PB disassembly and translational derepression of HMGA2. Taken together, this study has identified a function of PBs in the regulation of EMT in cancer.
Significance:
Systematic investigation of the influence of posttranscriptional regulation on cancer cell motility established a connection between P-body–mediated translational control and EMT, which could be therapeutically exploited to attenuate metastasis formation.
Table S2 from PUMA/RIP3 Mediates Chemotherapy Response via Necroptosis and Local Immune Activation in Colorectal Cancer
Authors: Chen Dongshi , Ermine Kaylee , Wang Yi-Jun , Chen Xiaojun , Lu Xinyan , Wang Peng , Beer-Stolz Donna , Yu Jian , Zhang Lin
Published: March 2024

Table S2. PCR primers used in the experiments described in this manuscript are listed.
Table S1 from PUMA/RIP3 Mediates Chemotherapy Response via Necroptosis and Local Immune Activation in Colorectal Cancer
Authors: Chen Dongshi , Ermine Kaylee , Wang Yi-Jun , Chen Xiaojun , Lu Xinyan , Wang Peng , Beer-Stolz Donna , Yu Jian , Zhang Lin
Published: March 2024

Table S1. Key reagents used in the experiments described in this manuscript are listed.
Figure S7 from PUMA/RIP3 Mediates Chemotherapy Response via Necroptosis and Local Immune Activation in Colorectal Cancer
Authors: Chen Dongshi , Ermine Kaylee , Wang Yi-Jun , Chen Xiaojun , Lu Xinyan , Wang Peng , Beer-Stolz Donna , Yu Jian , Zhang Lin
Published: March 2024

Figure S7. 5-FU-induced and RIP3-mediated necroptosis could be restored by WT p53 or p53-independent inducers of PUMA in p53-deficeint CRC cells.
Figure S6 from PUMA/RIP3 Mediates Chemotherapy Response via Necroptosis and Local Immune Activation in Colorectal Cancer
Authors: Chen Dongshi , Ermine Kaylee , Wang Yi-Jun , Chen Xiaojun , Lu Xinyan , Wang Peng , Beer-Stolz Donna , Yu Jian , Zhang Lin
Published: March 2024

Figure S6. 5-FU-induced apoptosis in LoVo and Lim1215 cells was mediated by the induction of DR5.
Figure S9 from ERBB4-Mediated Signaling Is a Mediator of Resistance to PI3K and BTK Inhibitors in B-cell Lymphoid Neoplasms
Authors: Arribas Alberto J. , Napoli Sara , Cascione Luciano , Barnabei Laura , Sartori Giulio , Cannas Eleonora , Gaudio Eugenio , Tarantelli Chiara , Mensah Afua A. , Spriano Filippo , Zucchetto Antonella , Rossi Francesca M. , Rinaldi Andrea , Castro de Moura Manuel , Jovic Sandra , Bordone Pittau Roberta , Stathis Anastasios , Stussi Georg , Gattei Valter , Brown Jennifer R. , Esteller Manel , Zucca Emanuele , Rossi Davide , Bertoni Francesco
Published: March 2024

Ridgeplot on surface levels of ERBB4 by FACS in Karpas1718 resistant cells upon genetic silencing (siRNA) of ERBB2 (yellow), ERBB4 (red) or concomitant ERBB2 and ERBB4 (brown). Silencing control in grey and negative control in black. Data derived from two independent experiments. Statistically significant differences (p<0.05) were evaluated by t-test performed on mean MFI values.
Figure S5 from ERBB4-Mediated Signaling Is a Mediator of Resistance to PI3K and BTK Inhibitors in B-cell Lymphoid Neoplasms
Authors: Arribas Alberto J. , Napoli Sara , Cascione Luciano , Barnabei Laura , Sartori Giulio , Cannas Eleonora , Gaudio Eugenio , Tarantelli Chiara , Mensah Afua A. , Spriano Filippo , Zucchetto Antonella , Rossi Francesca M. , Rinaldi Andrea , Castro de Moura Manuel , Jovic Sandra , Bordone Pittau Roberta , Stathis Anastasios , Stussi Georg , Gattei Valter , Brown Jennifer R. , Esteller Manel , Zucca Emanuele , Rossi Davide , Bertoni Francesco
Published: March 2024

Parental (green) and resistant (orange) levels of DNA promoter methylation (A) and gene expression (RNA-seq, B) of DUSP4, and p-ERK upon 1µM of idelalisib (Flow cytometry).
Figure S4 from ERBB4-Mediated Signaling Is a Mediator of Resistance to PI3K and BTK Inhibitors in B-cell Lymphoid Neoplasms
Authors: Arribas Alberto J. , Napoli Sara , Cascione Luciano , Barnabei Laura , Sartori Giulio , Cannas Eleonora , Gaudio Eugenio , Tarantelli Chiara , Mensah Afua A. , Spriano Filippo , Zucchetto Antonella , Rossi Francesca M. , Rinaldi Andrea , Castro de Moura Manuel , Jovic Sandra , Bordone Pittau Roberta , Stathis Anastasios , Stussi Georg , Gattei Valter , Brown Jennifer R. , Esteller Manel , Zucca Emanuele , Rossi Davide , Bertoni Francesco
Published: March 2024

(A) Heatmap of functionally annotated genes showing log2-scaled fold change and -log10 adjusted P-value (FDR) by RNA-seq comparing K1718 parental and resistant cells. (B) Gene set enrichment analyses (GSEA, Broad Institute) comparing parental and resistant per each line. Statistically significant differences with values of absolute NES higher than1, P <0.05 and FDR <0.25.