bluuebunny/crossref_metadata_2025 huggingface dataset:
TRATAMIENTO DE PACIENTES T1DM UTILIZANDO UN ALGORITMO NEURO-DIFUSO DE CONTROL ÓPTIMO INVERSO: UN ENFOQUE DE PROTOTIPADO RÁPIDO
Authors: Rios Yuliana , García-Rodríguez J.A. , Sanchez Edgar , Durán Acevedo Cristhian Manuel
Published: February 2020

Resumen: La condición de Diabetes Mellitus Tipo 1 (DMT1) ocurre cuando el páncreas se comporta de manera anormal e impide la producción de insulina parcialmente o totalmente. Por lo tanto, la glucosa no es metabolizada para convertirse en una fuente natural de energía y permanece en el torrente sanguíneo. Esta enfermedad causa miles de muertes alrededor del mundo. Los sectores de salud, así como la comunidad científica, han fortalecido los esfuerzos para proporcionar tratamientos más efectivos. En este trabajo, se expone un novedoso enfoque de control neuro-difuso para la regulación de la glucosa en sangre en pacientes virtuales con DMT1. La estrategia es diseñada tal que las funciones de membresía están definidas para determinar la tasa de infusión de insulina para evitar eventos de hiperglucemia e hipoglucemia. Adicionalmente, se lleva a cabo un prototipado rápido programando la ley de control óptimo inverso en la tarjeta de desarrollo LAUNCHXL-F28069M de Texas Instruments Inc. El análisis de la variabilidad de control (Siglas en inglés CVGA) obtenido a través del simulador Uva/Padova muestra claramente un desempeño satisfactorio para la reducción de hiperglucemia e hipoglucemia en una población de 10 adultos virtuales. De esta manera, el trabajo tiene como objetivo expandir la investigación de la diabetes hacia el Páncreas Artificial (PA) como un dispositivo programable.
LRS1: UN ROBOT SOCIAL DE BAJO COSTO PARA LA ASIGNATURA “PROGRAMACIÓN 1”
Authors: Pérez Jesús , Castro José
Published: February 2020

Los robots sociales han generado efectos positivos en el contexto educativo a través de diferentes roles: tutor, compañero y aprendiz. Los estudiantes de la asignatura “Programación 1” se han mostrado desmotivados en los últimos semestres. En aras de motivar el aprendizaje de los estudiantes de “Programación 1” se propone la incorporación de un robot social dentro de la dinámica de las clases. La adquisición de robots sociales comerciales es muy costosa, por lo tanto, se construye un robot social minimalista con tres habilidades principales: hablar, cambiar la expresión facial (triste, normal y feliz) y mover el cuello (arriba, abajo, izquierda, derecha y centro). El robot social construido (denominado LRS1) fue incorporado como tutor en una actividad denominada “dictado” que  pertenece al normal desarrollo de la asignatura, cuyos resultados obtenidos favorecen la incorporación de un robot social de bajo costo para motivar el aprendizaje en la asignatura.
PROCESAMIENTO DE SEÑALES EMG EN UN SISTEMA EMBEBIDO PARA EL CONTROL NEURONAL DE UN BRAZO ROBÓTICO
Authors: Cantillo Maldonado Alejandro , Gualdron Guerrero Oscar , Ortiz Sandoval Jesús
Published: February 2020

El objetivo de este trabajo es adquirir las señales EMG del brazo humano, para entrenar una red neuronal que pueda clasificar diferentes movimientos, de al menos 3 grados de libertad para controlar un brazo robótico. Para esto, se diseñó la adquisición y el acondicionamiento del sistema de señales EMG. Los músculos responsables del movimiento de la mano, el antebrazo y el brazo se identificaron para ubicar los electrodos en el músculo indicado. Se empieza con una posición de referencia para el movimiento de la mano, el antebrazo y el brazo. Las señales del sistema de adquisición y acondicionamiento se enviaron a la tarjeta de desarrollo ADC, donde se implementó un algoritmo que analizó la grabación de señales EMG para generar los datos con los que se entrenó la red neuronal. Luego, la red neuronal se implementó en el sistema integrado (BEAGLEBONE Black Rev. C) y se combinó con el brazo robótico.
MODELADO Y SIMULACIÓN DE UN SISTEMA DE ENFRIAMIENTO PARA MANTENER LA TEMPERATURA DE TRABAJO DE UN DINAMÓMETRO HIDRÁULICO.
Authors: Blanco Ojeda Frank Wiliam , Carrillo Pabón Yeyner Alveiro , Bermúdez Santaella José Ricardo , Marcucci Pico David Fernando
Published: February 2020

Este documento describe el procedimiento para el modelado y simulación de un sistema de enfriamiento para mantener la temperatura de trabajo de un dinamómetro hidráulico, este dispositivo es utilizado para la caracterización de motores de combustión interna en términos de velocidad, torque y potencia. Durante este proceso se aumenta la temperatura en el fluido de trabajo del dinamómetro hidráulico debido a la carga ejercida al motor de combustión de interna, dicho aumento de temperatura afecta el correcto funcionamiento del dinamómetro, por lo que se hace necesario emplear un sistema de enfriamiento, el cual es modelado e implementado en la herramienta Matlab-simulink® a través de las ecuaciones que rigen su comportamiento, por último se realizó la validación del modelo matemático a través de la comparación de datos experimentales, observando que el error fue de 4.6 %, obteniendo de esta forma una herramienta validada para el sistema de enfriamiento del dinamómetro hidráulico.
OPTIMIZACIÓN EN EL DISEÑO ESTRUCTURAL DE PÓRTICOS DE CONCRETO USANDO SAP2000
Authors: Mejía Orozco William Alberto , Orozco Ospino Javier Enrique
Published: February 2020

Se han desarrollado distintas investigaciones sobre la optimización de estructuras, implementándose diferentes algoritmos con diversos alcances. En esta investigación se optimiza el diseño de pórticos mediante la Interfaz de Programación de Aplicaciones (API) del programa SAP2000. Fue implementado un algoritmo mediante un código en Visual Basic, que permitió acceder a los comandos de dicha API, para realizar procesos iterativos de diseño estructural. Tomando 10 cm como valor inicial de todas las secciones transversales para incumplir los criterios de diseño en SAP2000, se logró la optimización estructural por medio de un ciclo repetitivo donde se aumentaban las dimensiones de dichas secciones transversales hasta que cada elemento tuviera las menores dimensiones posibles de su sección transversal. El código desarrollado permitió realizar la optimización en siete ciclos repetitivos en un tiempo muy reducido (aproximadamente dos minutos) en comparación con el proceso únicamente con el programa SAP2000 en interacción del usuario con su interfaz.
SOFTWARE MOVIL PARA RECONOCIMIENTO, SEGUIMIENTO Y CONTROL DE LAS PLANTAS DEL VIVERO INTELIGENTE DE LA UNIVERSIDAD FRANCISCO DE PAULA SANTANDER OCAÑA
Authors: Coronel Rojas Luis Anderson , Rico Bautista Dewar , Cuesta Quintero Fabián Ranulfo , Barrientos Avendaño Edwin , Pedraza Villadiego Eimar Alveiro
Published: February 2020

Este artículo tiene como objetivo mostrar los aspectos del desarrollo de una aplicación móvil. Permite dar soporte a los procesos de registro de hoja de vida de las diferentes plantas objeto de estudio del jardín Botánico Jorge Enrique Quintero Arenas de la universidad Francisco de Paula Santander Ocaña. En la primera fase, se realizó un análisis de los diferentes formatos físicos que actualmente lleva el administrador de la granja para la toma de datos de interés. En la segunda, la sistematización de la captura de información a través de interfaces amigables fácil de utilizar sobre una App Móvil con características que permitirán identificar a cada planta con tecnología códigos QR. Se agilizaron las consultas, reportes, trazabilidad e identificación de procedimientos e intervenciones realizadas a cada una de las plantas que están en proceso de supervisión por motivos científicos e investigativos, logrando ser una herramienta de apoyo para la toma de decisiones.
IMPLEMENTACIÓN DE UN SISTEMA PROXY DE NAVEGACION SEGURA EN EL GET DE CIENFUEGOS
Authors: Castellanos Hernández Juan Manuel , López Pérez Borroto Frank Manuel
Published: February 2020

El objetivo fue implementar un sistema de proxy gratuito basado en software libre para el logro de mayor seguridad y control en el Grupo de Electrónica para el Turismo de Cienfuegos (GET). Esta entidad utiliza un proxy Kerio para el control de la red, programa limitado por la compra de licencias. Se identificaron softwares y protocolos existentes para un sistema proxy de navegación segura. Se caracterizó la red de datos del GET de Cienfuegos. Se compararon los softwares existentes para el sistema. Se propuso el Squid como servidor proxy por su fortaleza y seguridad, el E2guardian como filtro web por su potencial, el Squish para el control de cuota por ser el único programa de software libre. Además, se escogieron los métodos de autenticación NTLM por ser el método más seguro entre los tres niveles de autenticación del Squid, Se implementó en una Pc corei3 con el Promox versión 4.4.
EFECTOS DE LAS CARGAS PROGRESIVO EXCENTRICAS EN LOS EXTENSORES DE RODILLA SOBRE LA FUERZA MAXIMA Y FUERZA EXPLOSIVA EN ESTUDIANTES UNIVERSITARIOS. .
Authors: Mariño Landazabal Nelson Adolfo , Diaz Castiblanco Karina , Jaimes laguado Marco Fredy
Published: February 2020

El propósito de este estudio fue analizar los efectos de las cargas progresivo excéntricas en los extensores de la rodilla sobre la fuerza máxima y fuerza explosiva en jóvenes universitarios de 18 a 25 años.  La muestra escogida por método no probabilístico, estuvo conformada por 40 estudiantes, pertenecientes a la tecnología en educación Física, Recreación y Deportes de la Universidad del Magdalena. Dicha muestra fue  dividida en dos grupos en forma aleatoria: Grupo control (22,71 ±1,79 años, 64,06 ± 10,61 Kg, 1,68 ± 0,10 mts) y Grupo Experimental (23 ±1,28 años, 67,89 ± 9,43 Kg, 1,68 ± 0,08 mts).   A partir de la aplicación del programa de entrenamiento a 15 semanas y después del análisis estadístico,  se establecieron como resultados un porcentaje de mejora del 15% en el grupo experimental para la variable fuerza explosiva, y un porcentaje de mejora superior al 40% para la variable fuerza máxima; a su vez una diferencia altamente significativa *** (P<=0.001), entre el grupo experimental con respecto al grupo control en la evaluación final.  Dichos resultados, sugieren que un programa de entrenamiento sistemático  con cargas progresivo excéntricas sobre los extensores de rodilla, produce efectos positivos sobre la fuerza explosiva calculada  través de la altura en los saltos SJ y CMJ y fuerza máxima en el ejercicio de sentadilla.
ESTRATEGIA METODOLOGICA PARA LA ENSEÑANZA-APRENDIZAJE DE LA TECNICA DEL GOLPEO DEL BALÓN CON EL PIE EN EL FÚTBOL
Authors: Zambrano Tony , Vera José Luis , Merchan Rony , Jaimes laguado Marco Fredy
Published: February 2020

El presente trabajo tuvo como propósito diseñar una estrategia metodológica basada en la enseñanza-aprendizaje fusionando los métodos analítico y global los cuales nos sirvieron para planificar el macrociclo de trabajo con sus respectivos, mesociclos, microciclos y unidades de trabajo diario. Este trabajo de investigación es de perfil casiexperimental cuya población son 450 niños que pertenecen a la institución educativa COLEGIO INTEGRADO PETROLEA; para la selección de la muestra se realizó mediante la modalidad no probabilística seleccionando así niños los cuales cumplían con las características necesarias para llevar a cabo esta investigación. El principal criterio para la selección de los niños fue tener más de 7 años de experiencia laborando en distintas escuelas de formación deportiva en futbol. Luego de terminada la intervención de 5 meses a través de los mesociclos con sus respectivos propósitos, se concluyó que, la aplicación de esta propuesta metodológica obtiene resultados significativos en cuanto al mejoramiento de la técnica del golpeo del balón con las principales superficies de contacto de las dos piernas. Se recomienda a los encargados de las escuelas de formación deportiva hacer mucho más énfasis en la técnica ya que sin este aspecto no se podría llevar a cabo un trabajo táctico acorde a las necesidades de un partido de futbol.
ANALISIS DE ACERO LAMINADO ANTES Y DESPUÉS DE SOLDADO, MEDIANTE PRUEBAS DE METALOGRAFÍA Y MACROATAQUE
Authors: Higuera Fabián , Salamanca Sarmiento Juan Rodrigo , Acosta Joya Luis Fernando , Acero Becerra Mateo
Published: February 2020

Este trabajo estudia el acero AISI-SAE 1020, que se encuentra en el mercado en diversos perfiles y tamaños, mediante el empleo de dos ensayos: Metalografía (en dirección axial y transversal) y Macro ataque. La información referente a propiedades mecánicas se encuentra en catálogos del productor, sin embargo las propiedades evaluadas corresponden a evaluación de  la conformación metalográfica de dos productos laminados (Lamina y perfil cuadrado), en dos direcciones (largo y ancho), antes y después de la soldadura. Paralelo se realizó un macro ataque a  las muestras antes y después de la soldadura, para determinar las variaciones en la estructura del material. El manejo de las muestras se hizo en grupos por cada ensayo. El resultado de estos ensayos, presenta variaciones con respecto a documentos previos (libros y artículos), que se explican mejor al contrastar estas dos técnicas de evaluación de los aceros.
Arah Baru Pengembangan Ulumul Quran
Authors: Yusuf Mustain , Munawir Munawir
Published: February 2020

Muhkam science and mutasyabbih are the results of human construction. Its existence is clearly not absolutely true. As a science, muhkam and mutasyabbih are always open to all developments. This research - using Thomas Kuhn's shifting paradigm framework - analyzes the direction of the development of muhkam-mutasyabbih science starting from normal science, anomaly/crisis, and new paradigm. From this analysis, the answer is obtained that the construction of muhkam-mutasyabbih (normal science) is based on the textuality of the verse. This construction experiences anomaly and even crisis when dealing with maqashidul Qur'an, because by relying solely on verse textuality, there is often a counterproductive product between interpretation based on muhkam science and mutasyabbih with the maqashidul Qur'an itself. Here a new paradigm is born, value-based muhkam-mutasyabbih; muhkam is fundamental and universal values â€‹â€‹(ushul Al-Qur'an), while mutasyabbih are implementational values â€‹â€‹that are local-temporal (furu 'Al-Qur'an).
Exposing and exposing censorship: Backfire dynamics in freedom-of-speech struggle
Authors: Curry Jansen Sue , Martin Brian
Published: February 2020

Censorship can backfire because it is usually viewed as a violation of the right to free expression, which is widely valued as an ideal; under the Charter of the United Nations, freedom of expression is a universal human right. Backfire occurs, for example, when censorious attacks on a film or book cultivate increased demand for the forbidden work rather than restrict access to it. Censors can inhibit this backfire effect in various ways, including covering up the censorship, devaluing the target, reinterpreting the action, using official channels, and using intimidation and bribery. These five methods to inhibit backfire from attacks on free speech are illustrated by a variety of cases, including attacks that backfired and ones that did not. This analysis provides guidance for effectively opposing attacks on free expression.
Bullying the public broadcaster: Threatening the ABC's role
Authors: Dempster Quentin
Published: February 2020

Public broadcasting in Australia has been under sustained attack for around 18-years now, both politically and through reduced funding. Although the Fraser Government (1975-1983) enacted legislation converting the ABC from the old broadcasting commission into a corporation (with its own borrowing and corporate treasury powers), the then Malcolm/Fraser/Doug/Anthony Liberal/National Coalition Government did not seem to hold more than the usual superficial grudges about our current affairs programmes' treatment of some  of their practitioners.
Media ownership policies: Pressures for change and implications
Authors: Barnett Steven
Published: February 2020

We are witnessing a wholesale restructuring of media ownership statutes throughout the world. It is difficult to think of a single developed or developing country which over the last 10 years has not introduced at least one change – and in many cases more – in its media ownership regimes. The direction is almost entirely one-way: towards a more liberal and deregulated environment which allows for more conglomeration of media companies, greater flexibility in foreign ownership, and fewer restrictions on ownership across different media. I want to address two important aspects of this worldwide phenomenon: first, why it is happening and the main forces driving these changes; and second, the implications for a free press, for diversity, and for journalism.
Better journalism or better profits?: A key convergence issue in an age of concentrated ownership
Authors: Quinn Stephen
Published: February 2020

Convergence has become an accepted form of journalism at media organisations around the world. These organisations are adopting a range of business models to find ways to pay for these innovations. The main drivers behind this radical change in media production are the disruptive forces that these two drivers behind this radical change in media production are consumers' changing media habits, cheaper digital technology, and the disruptive forces that hese two drivers generate. Technology also maes possible new forms of storytelling, which potentially allows jounrlaists the chance to do better jounrlists through convergence. This article focuses on the key issue of whether editorial managers and journalists are embracing convergence to save money, or to do better journalism. It begins by defining convergence (while accepting the wide variety of definitions) and describing two main models of implementation. It then considers the factors that hinder its introduction. Examples are provided of converged media around the world. This article ends with a warning about the dangers for democracy of misapplied convergence in an era of increasing concentration of ownership.
REVIEW: Globalisation for whom?
Authors: Hope Wayne
Published: February 2020

Review of The Three Waves of Globalisation: A History is a Developing Global Consciousness, by Robbie Robertson

Robertson's all-embracing, long dureé conception of globalisation provides important anthropological isights. However, the universalist scale of his narrative leads to over-generalised accounts of structural power and political opposition.
REVIEW: Correcting the myth of East Timor
Authors: Cronau Peter
Published: February 2020

Review of Reluctant Saviour: Australia, Indonesia and the Independence of East Timor, by Clinton FernandesBy trawling through the public record of the events of the time, Fernandes has amassed a convicing collection of little-known evidence showing just how reluctant the Australian Government was to assist the Timorese. He has used often obscure examples, passed-over by the media at the time, to show the true intent of the government.
The Māori public sphere
Authors: Stuart Ian
Published: February 2020

At this moment in New Zealand’s history there is a need for healthy political debate on a range of issues. Specifically, the foreshore and seabed issue has created division and fears between Māori and Pakeha and brought the Treaty of Waitangi to the fore again. As well, settlements of historic grievances with Māori have added to growing Pakeha unease. In this climate there is a need for wide-ranging public discussion of these issues, and the news media seem the obvious site for those discussions. But how well are the New Zealand news media fulfilling that role? This commentary takes the public sphere to be the sum total of all visible decision-making processes within a culture and uses this concept as an analytical tool to examine aspects of the health of New Zealand’s democracy. It uses discourse analysis approaches to show how the mainstream media are in fact isolating Māori from the general public sphere and, after outlining some general aspects of the Māori public sphere, argues that the news media’s methodologies, grounded in European-based techniques and approaches, are incapable of interacting with the Māori public sphere. I am arguing that while there is an appearance of an increased awareness and discussion of cultural issues, the mainstream media are, in reality, sidelining Māori voices and controlling the political discussion in favour of the dominant culture. They are therefore not fulfilling their self-assigned role of providing information for people to function within our democracy.

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REVIEW: Frank insights into Labour's controversial political maverick
Authors: Stokes Jon
Published: February 2020

Review of Black and White : John Tamihere, by John Tamihere with Helen BainA theme in the book is Tamihere's uncanny ability to survive utterances and actions that should have ended the career of almost any other politician. At the time this was true, However, in the now notorious Investigate magazine artcle in April, where he put his blockey boot into a number of powerful Labour Party colleagues, and snapped ties with a few more of his diminishing list of friends, he looks to have shattered an image of seeming invunerability.
REVIEW: 'Embedded' with the invaded Iraqi people
Authors: Robie David
Published: February 2020

Wilson's Long drive Through A Short War is a personal account of their time in Iraq during the invasion and a subsequent post-war visit to the country to see the fate of the people he had met. 

Hersh's Chain of Command provides many of the missing links to those seeking greater insight into the wider struggle of Iraq's civil war unleashed by the failure of US post-invasion policy, even if this is not officially admitted. His 'muckracking' investigations concentrate on the policy failures, corruptions and abuses of power.
The 'liberation' truth is unmentionable in America
Authors: Pilger John
Published: February 2020

Commentary: In Baghdad, the rise and folly of rapacious imperial power is commemorated in a forgotten cemetery called the North Gate. Dogs are its visitors; the rusted gates are padlocked, and skeins of traffic fumes hang over its parade of crumbling headstones and unchanging historical truth. Lieutenant-General Sir Stanley Maude is buried here, in a mausoleum befitting his station, if not the cholera to which he succumbed. In 1917, he declared: ‘Our armies do not come...as conquerors or enemies, but as liberators.’ Within three years, 10,000 had died in an uprising against the British, who gassed and bombed those they called ‘miscreants’. It was an adventure from which British imperialism in the Middle East never recovered.
The need to synthesise industry academy ambitions
Authors: Green Kerry
Published: February 2020

Journalism education in Australia, as it seems in New Zealand, finds itself between a rock and a hard place. On the one hand universities find themselves under pessure to provide courses that meet industry demands and enhance job success rates; on the other hand journalists seek to be recognised as professionals for a wide range of reasons. Among those reasons is the desire to raise the credibility of journalism in the public perception and the need to argue for higer rates of pay and improved conditions.
The politics of the media: A cynical synopsis
Authors: Ratuva Steven
Published: February 2020

"The power of the pen (or keyboard nowadays) can be used to inflame conflict, justify evil, create goodness, undermine political power, 'murder' as well as destroy; inform as well as misinform. Journalists compete to master these set of social and moral dichotomies for diverse reasons: to please their bossess and thus ensure easy social mobility up the busy corporate laddar; make their stories marketable and generate public legitimacy; make a political point or two; or simply to 'survive'. This complex interplay of social and ethical dichotomies provide the basis for media politics and thus the environment within which journalists 'survive' and sometimes 'die'.
Effectiveness of Common Agricultural Policy Implementation in Slovakia – European Project Implemeted by the Association of Agrarian and Environmental Lawyers
Authors: Palšová Lucia , Bohátová Zuzana , Floriš Norbert
Published: February 2020

The Common Agricultural Policy (CAP) is the oldest EU policy and is one of the supranational areas and policies of the European Union (EU). CAP introduced diverse legal and economic tools for comprehensive and smart restructuralisation of the Slovak agriculture and rural areas. With the purpose to improve the CAP implementation in Slovakia, the project “Effectiveness of Common Agricultural Policy implementation in Slovakia” (CAPE) was prepared and submitted by the Association of Agrarian and Environmental Lawyers. The project was approved by the Education, Audiovisual and Culture Executive Agency and it has been granted from September 2019 (Decision Nr. 2019–1802/001.001, Project Nr. 611792–EPP–1–2019–1–SK–EPPJMO–SUPPA). The idea to submit project proposal aroused from the need to contribute to improving the Common Agricultural Policy implementation in Slovakia. The main aim of the project is to perform the interdisciplinary research in the field of the effectiveness of CAP implementation in Slovakia with the specific objectives to discuss and advise local, regional, national policymakers and decision–makers on different aspects of the CAP implementation, transfer the research results and the expertise to the practice and to disseminate the project outcomes among interested target groups and civil society.
Contractual Cooperation of Municipalities for Performance of Transferred Competencies in the Building Sector
Authors: Marišová Eleonóra , Lichnerová Ivana
Published: February 2020

The reform of the self–governments in Slovakia caused the transfer of competencies from state authorities to municipalities. Every municipality is in accordance with Act no. 369/1990 Coll. on the Municipal Establishment obliged to ensure original and transferred competences for its inhabitants. However, for objective reasons, not all municipalities are able to perform them. Municipalities began to use the possibility of mutual contractual cooperation in accordance with the amendment to the Act on Municipal Establishment, under which municipalities can cooperate with each other for the purpose of carrying out a specific task or activity. Such cooperation between municipalities also exists for the purpose of exercising competence in the field of the building order. Pursuant to Act no. 50/1976 Coll. as amended, each municipality is a building authority. The aim of the paper is to qualitatively assess the reasons for contractual cooperation between the municipalities of the Nitra (NR) and Košice (KE) regions in the area of the building order (by using the method of structured interview). So far, 2 649 municipalities, which are a part of 189 joint building offices (JBO), have used the possibility of mutual contractual cooperation in the SR. Specifically, in the NR region there are 343 municipalities, which are part of 26 JBOs and in the KE region 391 municipalities, which are part of 28 JBOs. The qualitative method was used to find out the opinions of the building offices. Based on the obtained results, an optimal solution for problems of cooperation of municipalities was proposed by adopting new legislation, namely by the allocation of building offices to the seats of registry offices.
A new approach to cardiac fat volume assessment and the correlation with coronary artery calcification
Authors: Torkian Pooya , Langroudi Taraneh Faghihi , Negarestani Amir Masoud , Shabestari Abbas Arjmand , Naderian Mohammadreza , Tabary Mohammadreza , Khaheshi Isa
Published: February 2020

Background. Coronary artery disease (CAD) is the foremost cause of death in the most developed societies. Plaque formation in epicardial coronary arteries and ensuing inflammation are a known pathophysiologic factor of CAD.

Objectives. We aimed to separately and simultaneously evaluate the correlation between pericardial fat pad volume and overall peri-coronary epicardial adipose tissue (EAT) thickness with coronary calcium score (CCS) to improve risk stratification of CAD.

Methods. We retrospectively reviewed patients who underwent a non-invasive contrast-enhanced coronary multidetector CT (MDCT) angiography. Peri-coronary EAT thickness, pericardial fat pad volume and CCS were obtained by an expert radiologist from the patients coronary multidetector CT (MDCT) angiography.

Results. We included 141 symptomatic patients (86 men, 55 women) with an average age of 53.53 ± 12.92. An increment of overall peri-coronary EAT thickness (1/3 × (left anterior descending artery (LAD) + left circumflex artery (LCx) + right coronary artery (RCA)) was associated with a 49% increase in the odds for the presence of coronary artery calcification (CAC) (P = 0.004). Significant predictability of peri-coronary EAT-average was seen in diagnosing calcified plaque. Pericardial fat pad volume was positively correlated with overall peri-coronary EAT thickness in age and body mass index (BMI)-adjusted linear regression models, (P < 0.001).

Conclusion. Our results amplify previous idea that peri-coronary EAT and pericardial fat pad volume might act as useful markers and better indicators of CCS based on Agatston score in comparison with BMI or body weight in order to reveal subsequent CADs.
Differences in the "Inclusion Need Orientation" of Students from a Historically Black University Versus Predominantely White Institutions
Authors: Gurley Kathleen , Herd Ann
Published: February 2020

The importance of inclusion and social adjustment within the college or university setting have been well documented by studies on student retention. The primary purpose of this study was to investigate the difference in "inclusion need orientation" between students at three different universities--a historically Black university (HBCU) and two predominantly White institutions (PWI). Students at the HBCU had significantly lower scores than the students at the PWIs on "expressed and wanted inclusion" using Schutz's FIRO-B (Fundamental Interpersonal Relations Orientation) instrument. Lower scores on expressed inclusion need suggest that students at the HBCU feel less comfortable asking others to join them in activities than students at the PWIs, while lower scores on wanted inclusion need sugges that students at the HBCU have less desire to be invited to join activities than students at the PWIs. Implications of these findings are discussed.
Studi Intensitas Pencahayaan Terhadap Puncak Produksi Ayam Petelur Fase Layer di UD. Mahakarya Farm Banyuwangi
Authors: Kustiawan Erfan , Rukmi Dyah Laksito , Imam Shokhirul , Permadi Sandi Owen
Published: February 2020

The objective of this case study was to evaluate good lighting levels in laying hens. The data were collected for three months at UD. Mahakarya Farm Banyuwangi. A total of 4.400 heads of layer chicken were used in this study. The lighting intensityused were 15 lux in cage A and 10 lux in cage B. The average of egg production were75.91% and 73.57% for cage A (15 lux) and cage B (10 lux), respectively. The average of egg weight were 59.37 g and 59.23 gfor cage A (15 lux) and cage B (10 lux), respectively. The results of this study presented that layer chicken aged 25 weeks produced better production efficiency values by 10 lux. At the end of production period(38 weeks) increased production efficiency by 15 lux.
Transnacionāla krāpšana: starptautiskās tiesiskās sadarbības modernizācijas problēmas
Authors: Ārensone Kristīne
Published: February 2020

Aktuālas kriminoloģiska rakstura problēmas analīzei ir veltīts arī Kristīnes Ārensones raksts. Noziedzībai, tostarp krāpšanām, globalizācijas apstākļos aizvien izteiktākas kļūst transnacionālas iezīmes, kas nosaka nepieciešamību nodrošināt starptautisko tiesisko sadarbību. K. Ārensone lasītāju uzmanību pievērš sadarbības modernizācijas virzieniem un problēmām.

Kristīne Ārensone’s article also presents analysis of the issue of a topical criminological nature. Criminality, including embezzlement, possesses more and more transnational features due to the ever-increasing globalisation, which calls for urgent need for international legal cooperation. K. Ārensone intrigues readers through addressing modernisation trends and problems of such cooperation approaches.
Association between socio-demographic factors and blood groups with risk of diabetes mellitus in Dangila hospital, Awi Zone, North West Ethiopia
Authors: Berhanie H. , Mihretie Z. , Anandapandian K. T. K.
Published: February 2020

Introduction:

Diabetes mellitus (DM) is a metabolic disease which is categorized as hyperglycemia. This disease is a multi-factorial trait that appears by interactions of genetic, immunological, and environmental factors.

Materials and Methods:

The study was conducted through case–control method of study in Dangila, Ethiopia. The total number of individuals included as study subjects was 403, of these 201 were diabetic patients (81 type I and 120 type II diabetic patients) and 202 were non-diabetics patients. From 403 participants, 225 were males and 178 were females. The data were analyzed using SPSS version 21.0.

Results:

A significant association was obtained between sex, age, marital status, blood group and Rh factors with diabetes mellitus but not with residence and family histories. Male from sex, above 40 years from age, married from marital status were more susceptible for diabetes, contrary females, 16-40 years and singles were lower risk of diabetic than other comparable categories. In case of blood group, type A was more susceptible and blood type O and AB were lower risk rate of diabetes mellitus. Additionally blood AB/Rh negative individuals were not affected by type I diabetes mellitus.

Conclusion:

The socio-demographic factor sex, age, and marital status showed a significant association but family history and residence did not show a significant association with DM. In blood groups, the other important point that observed was, no one founds who had AB blood groups that diagnose type one DM. The majority of the study participants had Rh-positive, though the significant difference between diabetic and non-diabetic was observed only in Rh negatives.
Photo-Crosslinkable, Insulating Silk Fibroin for Bioelectronics with Enhanced Cell Affinity
Authors: Ju Jie , Hu Ning , Cairns Dana , Liu Haitao , Timko Brian
Published: February 2020

Bioelectronic scaffolds that support devices while promoting tissue integration could enable tissue hybrids with augmented electronic capabilities. Here, we demonstrate a Photo-crosslinkable Silk Fibroin (PSF) derivative and investigate its structural, electrical and chemical properties. Lithographically-defined PSF films offered tunable thickness and <1 μm spatial resolution, and could be released from a relief layer yielding freestanding scaffolds with cm-scale uniformity. These constructs were electrically insulating; multi-electrode arrays with PSF-passivated interconnects provided stable electrophysiological readouts from HL-1 cardiac model cells, brain slices and hearts. Compared to SU8, a ubiquitous biomaterial, PSF exhibited superior affinity toward neurons which we attribute to its favorable surface charge and enhanced attachment of poly-d-lysine adhesion factors. This finding is of significant importance in bioelectronics, where tight junctions between devices and cell membranes are necessary for electronic communication. Collectively, our findings are generalizable to a variety of geometries, devices and tissues, establishing PSF as a promising bioelectronic platform.
Protein Unfolding in Freeze Frames: Intermediates of Ubiquitin and Lysozyme Revealed by Variable Temperature Ion Mobility-Mass Spectrometry
Authors: Ujma Jakub , Upton Rosie , Benoit Florian , Bellina Bruno , Barran Perdita
Published: February 2020

As experimentalists, we normally rely on assessing observables. However sometimes, the most fascinating phenomena are not noticeable directly. An example of such is our data and the corresponding interpretation presented in this manuscript. We have designed and constructed a ion mobility mass spectrometer (acs.analchem.6b01812) capable of taking ion mobility measurements over a temperature range from 150-500K. We chose to benchmark this new instrument, using the small proteins Ubiquitin and Lysozyme extensively studied as a “model proteins” in many in-silico, -solution and -vacuo studies focusing on conformational dynamics.In this work, we activate and subsequently thermally equilibrate the protein ions at several temperatures prior to collision cross section measurement. For Ubiquitin at 300K and above, the protein unfolds in a “step-wise” fashion as previously reported (by David Clemmer) and for other proteins including lysozyme, and cytochrome c by us and also by Martin Jarrold. However, to our surprise, activation and equilibration of ubiquitin at 150K yields a plethora of highly extended forms of the protein. We attribute these as kinetically trapped unfolding intermediates. Since the activation process is the same at both temperatures we infer that the unfolding must always proceed via these extended intermediate forms, which then converge to commonly reported conformations. Intriguingly, this “convergence” appears to occur mostly below the temperature of irreversible conformational thermal transition of Ubiquitin reported in many solution phase studies. For Lysozyme the same experiment is performed and similar results are obtained although we cannot activate the gaseous ensemble too far from the native fold and the activation barrier to refolding is low enough to allow it to be re-accessed on the experimental timescale we use.
Rethinking the Magnetic Properties of Lepidocrocite: A Density Functional Theory and Cluster Expansion Study
Authors: Pope Daniel , Clark Aurora , Prange Micah , Rosso Kevin
Published: February 2020

The iron oxyhydroxide lepidocrocite (γ-FeOOH) is an abundant mineral critical to a number of chemical and technological applications. Of particular interest is the ground state and finite temperature magnetic order, and the subsequent impact this has upon crystal properties. The magnetic properties, investigated in this work are governed primarily through superexchange interactions, and have been calculated using density functional theory and cluster expansion methods. Quantification of these exchange terms has facilitated the determination of the ground state magneto-crystalline structure and subsequent calculation of its lattice constants, elastic moduli, cohesive enthalpy, and electronic density of states. Further, using a collinear magnetic configuration model, the magnetic heat capacity versus temperature has been studied and the N ́eel temperature obtained.
Cooperative and Fully Reversible Photocatalytic Colour Switching Activation in Graphene-Copper-TiO2 Nanoparticles
Authors: Tobaldi David Maria , Lajaunie Luc , Dvoranova Dana , Figueiredo Bruno , Seabra Maria Paula , Calvino José , Brezova Vlasta , Labrincha Joao Antonio
Published: February 2020

Nanostructured systems showing reversible colour switching are envisaged to play a significant role in photo-switches, photo-optical sensors, smart windows, displays, optical storage memories. Most of the materials exhibiting reversible colour switching are organic compounds. However, their UV-light activation, low thermal and chemical stability, as well as harmful synthesis methods, are of limit for their extensive use. In this research, we have created an inorganic switchable photochromic material exploiting: (i) TiO2 ability of creating an exciton upon excitation, (ii) copper as the chromophore, and (iii) graphene’s extraordinarily high electron mobility. Our material showed itself to be able to work under visible-light, its photochromic property being three times faster than conventional titania based photochromic materials, reaching a stable change in colouration after only 30 mins of visible-light irradiation (versus > 120 min in conventional Cu-TiO2). With the addition of just 1 wt% graphene, the material exhibited a staggeringly stable photochromic switching over repeated cycles. These results relate to the best previously reported values for any form of TiO2-based photochromic material. This is therefore an excellent candidate for smart self-cleaning windows, and other chromic devices and applications.
Dual Cobalt and Photoredox Catalysis Enabled Intermolecular Oxidative Hydrofunctionalization
Authors: Sun Han-Li , Yang Fan , Ye Wei-Ting , Wang Jun-Jie , Zhu Rong
Published: February 2020

A general protocol has been developed for the Markovnikov-selective intermolecular hydrofunctionalization based on visible-light-mediated Co/Ru dual catalysis. The key feature involves the photochemical oxidation of an organocobalt(III) intermediate derived from hydrogen atom transfer, which is supported by electrochemical analysis, quenching studies and stoichiometric experiments. This unique redox process enables the efficient branch-selective alkylation of pharmaceutically important nucleophiles (phenols, sulfonamides and various N-heterocycles) using a wide range of alkenes including moderately electron-deficient ones. Moreover, light-gated polar functionalization via organocobalt species was demonstrated.
Halogen Bonding: An Underestimated Player in Membrane–drug Interactions
Authors: Nunes Rafael , Vila Viçosa Diogo , Costa Paulo J.
Published: February 2020

Halogen bonds (HaBs) are noncovalent interactions where halogen atoms act as electrophilic species interacting with Lewis bases. These interactions are relevant in biochemical systems being increasingly explored in drug discovery, mainly to modulate protein–ligand interactions. In this work, we report evidence for the existence of HaB-mediated halogen–phospholipid recognition phenomena as our molecular dynamics simulations support the existence of favorable interactions between halobenzene derivatives and both phosphate (PO) or ester (CO) oxygen acceptors from model phospholipid bilayers, thus providing insights into the role of HaBs in driving the permeation of halogenated drug like molecules across biological membranes. This represents a relevant molecular mechanism, previously overlooked, determining the pharmacological activity of halogenated molecules with implications in drug discovery and development, a place where halogenated molecules account for a significant part of the chemical space. Our data also shows that, as the ubiquitous hydrogen bond, HaBs should be accounted for in the development of membrane permeability models.
Azetidinimines as a Novel Series of Non-Covalent Broad-Spectrum Inhibitors of β-Lactamases with Submicromolar Activities Against Carbapenemases of Classes A, B and D
Authors: Romero Eugénie , Oueslati Saoussen , Benchekroun Mohamed , D’Hollander Agathe C. A. , Ventre Sandrine , Vijayakumar Kamsana , Minard Corinne , Exilie Cynthia , Tlili Linda , Retailleau Pascal , Zavala Agustin , Elisée Eddy , Selwa Edithe , Nguyen Laetitia A. , Pruvost Alain , Naas Thierry , Iorga Bogdan I. , Dodd Robert , Cariou Kevin
Published: February 2020

The increasingly worrisome situation of antimicrobial resistances has pushed synthetic chemists to design original molecules that can fight these resistances. To do so, inhibiting β-lactamases, one of the main modes of resistance to β-lactam antibiotics, is one of the most sought-after strategies, as recently evidenced by the development and approval of avibactam, relabactam and vaborbactam. Yet molecules able to inhibit simultaneously β-lactamases belonging to different molecular classes remain scarce and currently there is no metallo-β-lactamase inhibitor approved for clinical use. Having recently developed a synthetic methodology to access imino-analogues of β-lactams (Chem. – Eur. J. 2017, 23, 12991,see ref) we decided to evaluate them as potential β-lactamase inhibitors and specifically against carbapenemases, which can hydrolyze and inactivate penicillins, cephalosporins and carbapenems. Herein we eport our findings that show that our newly developed family of molecules are indeed excellent β-lactamase inhibitors and that our lead compound can inhibit NDM-1 (0.1 µM), KPC-2 (0.4 µM), and OXA-48 (0.6 µM) even though these three enzymes belong to three different molecular classes of carbapenemases. This lead compound also inhibits the ESBL CTX-M-15 and the cephalosporinase CMY-2, it is metabolically stable, and can repotentiate imipenem against a resistant strain of Escherichia coli expressing NDM-1.
ĐIỀU KIỆN TẠO MÀNG VÀNG – ĐỒNG TRÊN ĐIỆN CỰC THAN THỦY TINH ĐỂ XÁC ĐỊNH LƯỢNG VẾT HgII BẰNG PHƯƠNG PHÁP VON-AMPE HÒA TAN ANOT XUNG VI PHÂN
Authors: Nhi Phương Nguyễn Thị , Diễn Phan Thị , Long Hoàng Thái
Published: February 2020

Điện cực màng hỗn hợp vàng – đồng trên nền điện cực than thủy tinh có thể được dùng để xác định lượng vết HgII bằng phương pháp von-ampe hòa tan anot xung vi phân. Điện cực này được chế tạo bằng kỹ thuật in-situ với dung dịch phân tích HgII chứa HClO4 5 × 10−3 M, AuIII 0,2 mg/L và CuII 0,05 mg/L ở thế –1100 mV. So với điện cực màng Au trên nền điện cực than thủy tinh thì điện cực màng hỗn hợp Au–Cu có độ lặp lại tốt hơn trong lúc chỉ cần sử dụng một lượng vàng nhỏ hơn để tạo màng. Giới hạn phát hiện HgII là 0,09 g/L ở thời gian điện phân làm giàu 250 s. Độ lặp lại của Ip là rất tốt (n = 20) ngay với mức nồng độ thấp của HgII (5 g/L, RSD = 2,6%).
ĐẶC TÍNH ĐIỆN HÓA CỦA ACID URIC, XANTHINE VÀ HYPOXANTHINE TRÊN BỀ MẶT ĐIỆN CỰC THAN THỦY TINH BIẾN TÍNH BẰNG POLYTHIOPHENE – CHITOSAN
Authors: Nhàn Đặng Thị Thanh , Phong Nguyễn Hải , Phương Huỳnh Thị Linh , Thắng Lê Quốc
Published: February 2020

Trong nghiên cứu này, điện cực than thủy tinh biến tính với polythiophene – chitosan đã được sử dụng để phân tích đồng thời xanthine (XA), hypoxanthine (HX) và acid uric (UA) bằng phương pháp von-ampe hòa tan anốt xung vi phân (DP-ASV). Đặc tính điện hóa trên bề mặt điện cực biến tính được nghiên cứu thông qua khảo sát sự ảnh hưởng của pH và tốc độ quét thế. Kết quả cho thấy số electron và số proton trao đổi trong phản ứng oxi hóa xảy ra trên bề mặt điện cực của các chất phân tích UA, XA và HX là bằng nhau. Quá trình xảy ra trên bề mặt điện cực biến tính là quá trình bất thuận nghịch. Quá trình điện hóa được kiểm soát bởi quá trình hấp phụ đối với HX, đồng thời bởi quá trình khuếch tán và hấp phụ đối với XA và UA.
LO LẮNG VỀ SỰ PHÚ DƯỠNG: NGHIÊN CỨU TRƯỜNG HỢP MỘT SỐ HỒ Ở THÀNH PHỐ ĐÔNG HÀ, TỈNH QUẢNG TRỊ
Authors: Hải Nguyễn Trung , Hùng Nguyễn Việt , Hợp Nguyễn Văn
Published: February 2020

Ba hồ đại diện ở thành phố Đông Hà, tỉnh Quảng Trị (hồ Khe Sắn, Đại An và Khe Mây) được lựa chọn để lấy mẫu và phân tích các thông số chất lượng nước: nhiệt độ, pH, DO, độ trong, TSS, độ dẫn điện (EC), COD, BOD5, TN, NH4+, NO3–, NO2–, TP, PO43– và chlorophyll-a (Chl-a) trong thời gian từ tháng 6 đến tháng 8 năm 2017. Các kết quả cho thấy mức ô nhiễm các chất hữu cơ (BOD5, COD) và các chất dinh dưỡng (TN, TP) ở hồ Khe Sắn và hồ Đại An cao hơn so với hồ Khe Mây (p < 0,05); nồng độ Chl-a trong các hồ cũng khá cao, trung bình dao động trong khoảng 9–84 μg/L, biểu hiện của sự phú dưỡng. Đối với cả 3 hồ, photpho là yếu tố quyết định sự phú dưỡng (90 % trường hợp có tỷ số TN/TP ≥ 6). Mức phú dưỡng của các hồ được đánh giá dựa vào chỉ số dinh dưỡng Carlson (TSI) và Wollenweider (TRIX): hồ Đại An và hồ Khe Sắn đã bị phú dưỡng (các giá trị TSI > 60 và TRIX = 6÷ 8), riêng hồ Khe Mây ở mức phú dưỡng trung bình – phú dưỡng với TSI > 50 và TRIX = 5÷6. Tương quan giữa chỉ số TSI, TRIX và các thông số chất lượng nước cũng được đánh giá.
Spin observables of (d,p) reactions off $^{12}$C within the Paris potential
Authors: Trần Hào Viết Nhân , Hồ Nguyên Khắc , Phạm Vinh Nguyễn Thành
Published: February 2020

Deuteron elastic scattering off $^{12}$C is described in the framework of three-body Faddeev-type equations. Analyzing powers are calculated using the PEST16 potential which is a separable rank-one representation of the Paris potential. Satisfactory agreement with the experimental data is found.