bluuebunny/crossref_metadata_2025 huggingface dataset:
Identity development, attraction, and behaviour of heterosexually identified men who have sex with men: scoping review protocol
Authors: Eaton Andrew D. , Scheadler Travis R. , Bradley Cara , McInroy Lauren B. , Beer Oliver W. J. , Beckwell Erin , Busch Adam , Shuper Paul A.
Published: September 2023

Background

Heterosexually identified men who have sex with men (H-MSM) are distinct from other heterosexual men and from gay, bisexual, and other sexual minority men. Specifically, H-MSM experience discordance between their sexual identity (i.e., heterosexual) and behaviours (i.e., sexual encounters with other men). This sexual identity-behaviour discordance can create barriers to obtaining healthcare and social support. Understanding and accepting H-MSM as they self-identify may be necessary to implement effective public health and psychosocial interventions. The aim of the present study is to provide an overview of research on H-MSM.

Methods

A scoping review will be conducted to identify and describe the identity development, attraction, and behaviour of H-MSM. This scoping review will also identify and describe current trends related to the recruitment of H-MSM and recommend directions for future research. Searches will be conducted in Academic Search Complete, APA PsychInfo, CINAHL Plus with full text, Education Research Complete, Gender Studies Database, GenderWatch, Health Source: Nursing/Academic Edition, LGBTQ + Source, MEDLINE, Psychology and Behavioral Sciences Collection, SocINDEX with full text, Sociological Collection, Social Work Abstracts, ProQuest Dissertations and Theses, and ResearchGate. Primary research studies published in peer-reviewed journals will be included. Dissertations and theses that include primary research on H-MSM will also be included. Reference lists, experts in the field, preprint servers, and relevant conferences will also be consulted for extant and in-progress literature. Two reviewers will independently pilot the data extraction form and conduct the title and abstract screening, with consultation from a research librarian. Seven reviewers will then conduct the full-text article screening. Thematic content analysis will guide the review; through independent review and reviewer meetings, themes and subthemes will be identified and reported from the extracted literature.

Discussion

This is the first known knowledge synthesis on H-MSM, seeking to better understand sexual identity-behaviour discordance amongst cisgender men. We anticipate that a theoretical framework of H-MSM’s sexuality, internal processes, and behaviours will be constructed from this review. Alongside implications for further research with H-MSM, this review may be relevant to sexually transmitted infection public health and to clinicians working in the field of male sexuality.

Systematic review registration

Open Science Framework:https://doi.org/10.17605/OSF.IO/MVY9H
Lessons learned from housing first, rapid rehousing trials with youth experiencing homelessness
Authors: Slesnick Natasha , Brakenhoff Brittany , Bunger Alicia , Chavez Laura , Cuthbertson Caleb , Famelia Ruri , Feng Xin , Fitzpatrick Maggie , Ford Jodi , Hatsu Irene , Holowacz Eugene , Jaderlund Soren , Kelleher Kelly , Luthy Ellison , Mallory Allen , Martin Jared , Pizzulo Alexis , Stone-Sabali Steven , Yilmazer Tansel , Wu Qiong , Zhang Jing
Published: September 2023

Background

Youth, 18 to 24 years, experiencing homelessness (YEH) are recognized as having developmental challenges dissimilar to older adults. Yet, research on efforts to end homelessness and prevent or intervene in drug use and mental health problems among youth have lagged behind that of adults. The Housing First (HF) Model which underlies Permanent Supportive Housing (PSH) and Rapid Re-Housing (RRH) has become preferred over treatment-first models.

Methods and results

We provide an overview of PSH and RRH studies to date and summarize our current understanding of their utility for use with YEH. Finally, we review our team’s current and past randomized trials testing RRH with YEH, providing lessons learned and recommendations.

Conclusion

Current research efforts to guide best practices are hampered by a lack of fidelity to HF principles, lack of randomized design, and lack of focus on youth. Lessons learned and recommendations from our work are offered to facilitate the future work of those who seek to end homelessness and address drug use and mental health problems among youth.
Comparative analysis of alignment algorithms for macular optical coherence tomography imaging
Authors: Jones Craig K. , Li Bochong , Wu Jo-Hsuan , Nakaguchi Toshiya , Xuan Ping , Liu T. Y. Alvin
Published: October 2023

Background

Optical coherence tomography (OCT) is the most important and commonly utilized imaging modality in ophthalmology and is especially crucial for the diagnosis and management of macular diseases. Each OCT volume is typically only available as a series of cross-sectional images (B-scans) that are accessible through proprietary software programs which accompany the OCT machines. To maximize the potential of OCT imaging for machine learning purposes, each OCT image should be analyzed en bloc as a 3D volume, which requires aligning all the cross-sectional images within a particular volume.

Methods

A dataset of OCT B-scans obtained from 48 age-related macular degeneration (AMD) patients and 50 normal controls was used to evaluate five registration algorithms. After alignment of B-scans from each patient, an en face surface map was created to measure the registration quality, based on an automatically generated Laplace difference of the surface map–the smoother the surface map, the smaller the average Laplace difference. To demonstrate the usefulness of B-scan alignment, we trained a 3D convolutional neural network (CNN) to detect age-related macular degeneration (AMD) on OCT images and compared the performance of the model with and without B-scan alignment.

Results

The mean Laplace difference of the surface map before registration was 27 ± 4.2 pixels for the AMD group and 26.6 ± 4 pixels for the control group. After alignment, the smoothness of the surface map was improved, with a mean Laplace difference of 5.5 ± 2.7 pixels for Advanced Normalization Tools Symmetric image Normalization (ANTs-SyN) registration algorithm in the AMD group and a mean Laplace difference of 4.3 ± 1.4.2 pixels for ANTs in the control group. Our 3D CNN achieved superior performance in detecting AMD, when aligned OCT B-scans were used (AUC 0.95 aligned vs. 0.89 unaligned).

Conclusions

We introduced a novel metric to quantify OCT B-scan alignment and compared the effectiveness of five alignment algorithms. We confirmed that alignment could be improved in a statistically significant manner with readily available alignment algorithms that are available to the public, and the ANTs algorithm provided the most robust performance overall. We further demonstrated that alignment of OCT B-scans will likely be useful for training 3D CNN models.
The efficacy and safety of perioperative administration of dexamethasone: a systematic review and meta-analysis
Authors: Najafzadeh Mohammad Javad , Shafiei Mohadeseh , Sharifi Meraj , Nazari Parvaneh , Nasiri Naser , Hashemian Morteza
Published: October 2023

Background

Perioperative prophylactic dexamethasone is commonly administered to reduce postoperative nausea and vomiting (PONV) and pain after surgery. In this study, we aimed to systematically review the efficacy and adverse effects of perioperative dexamethasone administration.

Methods

We conducted a systematic search until January 2023 in scientific databases, including PubMed, Scopus, Embase, Web of Science, and Google Scholar. After assessing the methodological quality of relevant studies, we synthesized those focusing on PONV, oral food intake tolerance, impaired wound healing, major postoperative complications, and postoperative infections following the perioperative administration of dexamethasone.

Results

A total of 27 studies were included in this systematic review and meta-analysis. The dexamethasone group showed decreased PONV (OR = 0.19; 95% CI 0.06–0.55), increased oral food intake tolerance (OR = 7.38; 95% CI 1.07–51.11), increased risk of impaired wound healing (OR = .48; 95% CI 0.52–4.21), decreased probability of postoperative infection (OR = 0.61; 95% CI 0.51–0.72), and increased risk of major postoperative complications (OR = 1.27; 95% CI 0.68–2.39) compared to the controls.

Conclusions

The results of our pooled data analysis showed that dexamethasone was superior to the control in terms of PONV, oral food intake tolerance, and postoperative infections.
Eating After Acute Psychosocial Stress in Healthy Men and Women: Sex Differences and Endocrine Mechanisms
Authors: Degroote Cathy , Renner Britta , Wickl Julia , Leven Anika , Wirtz Petra H
Published: September 2023

Context

Overweight and obesity have become a major health burden with a higher prevalence of obesity in women than in men. Mental stress has been discussed to play a role in this context.

Objective

We investigated endocrine mechanisms underlying eating after acute psychosocial stress and potential sex differences therein.

Methods

A total of 32 male and 31 female healthy participants underwent the Trier Social Stress Test before they tasted ice cream in a bogus taste test 15 minutes after stress. We repeatedly assessed the stress hormone cortisol and the satiety hormone cholecystokinin (CCK) in saliva as well as perceived hunger before and up to 1 hour after stress.

Results

Lower immediate total cortisol stress reactivity predicted higher hunger (Ps ≤ .004), but was not associated with food intake (Ps ≥ .90) or total CCK release (Ps ≥ .84). As compared to men, women ate less after stress (Ps < .001) and had consistently lower levels of hunger (Ps ≤ .024) and cortisol (Ps ≤ .008) as well as a lower immediate total cortisol stress reactivity (Ps = .002). Further, they differed in the kinetics of CCK over the total experimental procedure (Ps ≤ .011), in immediate reaction to stress (Ps ≤ .038), and after eating (Ps ≤ .072), with women’s CCK levels continuously decreasing while men’s CCK levels were reactive.

Conclusion

We found evidence for lower immediate total cortisol stress reactivity relating to higher perceived hunger, with lower cortisol levels in women. Unlike in men, CCK levels in women were not reactive to acute stress and eating and decreased continuously. Our results may suggest a higher risk for stress-induced eating in women.
Lesions of KNDy and Kiss1R Neurons in the Arcuate Nucleus Produce Different Effects on LH Pulse Patterns in Female Sheep
Authors: Goodman Robert L , Moore Aleisha M , Onslow Kayla , Hileman Stanley M , Hardy Steve L , Bowdridge Elizabeth C , Walters Burgundy A , Agus Sami , Griesgraber Max J , Aerts Eliana G , Lehman Michael N , Coolen Lique M
Published: September 2023

The current model for the synchronization of GnRH neural activity driving GnRH and LH pulses proposes that a set of arcuate (ARC) neurons that contain kisspeptin, neurokinin B, and dynorphin (KNDy neurons) is the GnRH pulse generator. This study tested the functional role of ovine KNDy neurons in pulse generation and explored the roles of nearby Kiss1 receptor (Kiss1R)-containing cells using lesions produced with saporin (SAP) conjugates. Injection of NK3-SAP ablated over 90% of the KNDy cells, while Kiss-SAP (saporin conjugated to kisspeptin-54) lesioned about two-thirds of the Kiss1R population without affecting KNDy or GnRH cell number. Both lesions produced a dramatic decrease in LH pulse amplitude but had different effects on LH pulse patterns. NK3-SAP increased interpulse interval, but Kiss-SAP did not. In contrast, Kiss-SAP disrupted the regular hourly occurrence of LH pulses, but NK3-SAP did not. Because Kiss1R is not expressed in KNDy cells, HiPlex RNAScope was used to assess the colocalization of 8 neurotransmitters and 3 receptors in ARC Kiss1R-containing cells. Kiss1R cells primarily contained transcript markers for GABA (68%), glutamate (28%), ESR1 (estrogen receptor-α) mRNA, and OPRK1 (kappa opioid receptor) mRNA. These data support the conclusion that KNDy neurons are essential for GnRH pulses in ewes, whereas ARC Kiss1R cells are not but do maintain the amplitude and regularity of GnRH pulses. We thus propose that in sheep, ARC Kiss1R neurons form part of a positive feedback circuit that reinforces the activity of the KNDy neural network, with GABA or glutamate likely being involved.
Assessment of relationship among traits and genotypes for melon (Cucumis melo) breeding
Authors: MAGHFIROH RAHMATUN NISFUL , SUWARNO WILLY BAYUARDI , SOBIR SOBIR , GUNAWAN ENDANG
Published: October 2023

Abstract. Maghfiroh RN, Suwarno WB, Sobir, Gunawan E. 2023. Assessment of relationship among traits and genotypes for melon (Cucumis melo) breeding. Biodiversitas 24: 4523-4531. Melon (Cucumis melo L.) is widely consumed as fresh fruit or juice, and therefore deeper analyses of fruit quality are needed for future breeding purposes. Breeders have a role in providing improved melon varieties that suit consumer ideotypes or preferences. This study aimed to (i) evaluate the performance of melon genotypes, (ii) estimate the correlation between quantitative traits, and (iii) determine the clustering among genotypes based on plant and fruit traits. This research evaluated 24 genotypes from inodorus, reticulatus, and makuwa groups that were carried out from March to June 2022 at a greenhouse in the Tajur experimental station of the Center for Tropical Horticulture Studies, Bogor, Indonesia. IPB HD 2-111 and IPB HD 2-100 had good quality based on soluble solids content, fruit shape, flesh texture, and rind color, and G30 was relatively superior on flesh thickness, fruit weight, and vitamin C. Based on the multiple regression analysis, it was known that petal width, petiole length, and days to harvest were significantly affected the proportion of fruit cavity width to the fruit diameter. The adjusted coefficient of determination (R2) was 0.569. Cluster analysis grouped 23 genotypes into three main clusters based on the neighbor-joining method. These results may be useful for selection in melon breeding programs.
Genetic diversity and its association with Phytophthora palmivora resistance in Durian (Durio zibethinus) using RAPD markers
Authors: NUMBA SUDIRMAN
Published: October 2023

Abstract. Numba S. 2023. Genetic diversity and its association with Phytophthora palmivora resistance in Durian (Durio zibethinus) using RAPD markers. Biodiversitas 24: 4542-4548. Durian (Durio zibethinus L.) is a popular tropical fruit that contributes significantly to regional economic value. Root and stem rot disease caused by Phytophthora palmivora has become a serious threat to the growth and development of durian. Indonesia has various local durian varieties that have the potential of resistant to P. palmivora. This study aims to analyze genetic diversity and its association with the resistance of durian to root and stem rot disease caused by P. palmivora using RAPD markers. Ten varieties of durian were compared with those of 2 wild species, namely D. kutejensis (Hassk.) Becc. and Boschia excelsa Korth.. The DNA profile analysis was performed by using 10 RAPD primers. Furthermore, cluster analysis was done using the NTSYS (Numerical Taxonomic and Multivariate Analysis System) ver. 2.0. Observation of the DNA profile (DNA banding pattern) showed that all the primers succeeded in producing amplified DNA fragments. Of the total 78 bands produced, 10 bands were considered monomorphic, while 68 bands (87.20%) were considered polymorphic. The high level of polymorphism causes a low level of similarity between varieties so that not all resistant varieties are grouped in the same cluster. This study found that the 1kb band produced by the OPA-2 primer was a potential gen associated with resistance to P. palmivora. It is suggested to carry out further tests on crosses of resistant and susceptible varieties.
Bioremediation potential of rhizosphere bacterial consortium in lead (Pb) contaminated rice plants
Authors: UBAIDILLAH MOHAMMAD , THAMRIN NURHALIZA , CAHYANI FADIA INTAN , FITRIYAH DINA
Published: October 2023

Abstract. Ubaidillah M, Thamrin N, Cahyani FI, Fitriyah D. 2023. Bioremediation potential of rhizosphere bacterial consortium in lead (Pb) contaminated rice plants. Biodiversitas 24: 4566-4571. Lead (Pb) is one of the toxic heavy metals detected in various chemical fertilizers and pesticides used in Indonesia. These chemicals can increase plant lead (Pb) accumulation and affect other organisms through its circulation with food chain. Excess amounts of Pb in soil may be remediated using different approaches such as bioremediation. Rhizosphere bacteria can be used as bioremediation agents to reduce Pb accumulation in plants and also increase plant growth. Actinomycetes, Azotobacter sp., Azospirillum sp., Rhizobium sp., Pseudomonas sp., Lactobacillus sp., Bacillus sp., and Streptomyces sp. are some of the several bacteria that can reduce lead (Pb) accumulation in plants by the ability to sequester Pb, change its oxidation state, or enable Pb to precipitate. This research was conducted to determine the ability of the rhizosphere bacterial consortium to prevent lead (Pb) accumulation in rice plants. This study confirmed that the application of rhizosphere bacterial consortium to rice plants contaminated with lead (Pb) can reduce the plant's lead (Pb) content by up to 45%. The use of a bacterial consortium did not significantly affect the growth parameters of the plant but increased root length by 41%, fresh weight by 32%, dry weight by 26%, and chlorophyll content by 25%, in rice plants contaminated with Pb.
Probiotics potential of lactic acid bacteria isolated from Slender Walking Catfish (Clarias nieuhofii)
Authors: LINGGA RAHMAD , ADIBRATA SUDIRMAN , ROANISCA OCCA , SIPRIYADI SIPRIYADI , WIBOWO RISKY HADI , ARSYADI AHMAD
Published: October 2023

Abstract. Lingga R, Adibrata S, Roanisca O, Sipriyadi, Wibowo RH, Arsyadi. 2023. Probiotics potential of lactic acid bacteria isolated from Slender Walking Catfish (Clarias nieuhofii). Biodiversitas 24: 4572-4580. Probiotics are living microorganisms or bioactive agents that positively impact animal digestion. They have successfully isolated from various sources. Recently, we isolated and characterized lactic acid bacteria (LAB) from slender walking fish (Clarias nieuhofii Valenciennes, 1840). The fish sample was obtained from Batu Rusa and Paya Benua Rivers in Bangka Island, Indonesia. LAB was isolated from the fish intestine using the pour plate method. The isolated LAB was then characterized based on their phenotypic traits, biochemical properties, and the 16S rRNA gene identification. The chosen isolates were tested to determine their ability to produce lactic acid, hemolytic and antibacterial activity, and antibiotic resistance. All isolates have the characteristic of rod-shaped and short rod-shaped cells with Gram-positive properties. Isolate KP1 showed the number of populations (2.89 x 107 CFU/mL) and lactic acid production with a concentration of 1.85%. All isolates exhibited no hemolysis activity and displayed sensitivity to antibiotics. The twelve lactic acid bacteria formed clear zones against Staphylococcus aureus and Escherichia coli. The results of the 16S rRNA gene identification indicated that isolates KB4, KB7, KB8, and KP1 belong to Lactobacillus vaginalis, Lactobacillus fermentum, Limosilactobacillus fermentum, and Levilactobacillus brevis, respectively. Lactic acid bacteria isolated from slender walking fish exhibited potential probiotic traits.
The impact of nickel mining on vegetation index in Molawe Sub-district, North Konawe District, Southeast Sulawesi, Indonesia
Authors: ADIDHARMA MOHAMMAD AFDHAL , SUPRIATNA SUPRIATNA , TAKARINA NOVERITA DIAN
Published: October 2023

Abstract. Adidharma MA, Supriatna, Takarina ND. 2023. The impact of nickel mining on vegetation index in Molawe Sub-district, North Konawe District, Southeast Sulawesi, Indonesia. Biodiversitas 24: 4581-4588. Nickel mining activities in Molawe Sub-district, North Konawe District, Southeast Sulawesi, Indonesia have modified the land cover structure over time due to increased mining exploitation zones. This study intends to assess changes in land cover in the Molawe Sub-district, particularly around mining regions. The NDVI index was applied to Landsat 7 ETM+ satellite imagery data in 2001 to identify land cover conditions before mining activities, then to Landsat 8 OLI imagery data in 2015 and 2020 to identify land cover after mining activities. These data are then used to compute annual changes in the extent of each land cover. The NDVI classification produces four land cover types: non-vegetation, open soil, sparse vegetation, and moderate vegetation. The study shows that non-vegetation and open ground cover types experienced a significant increase in area from 2001 to 2015 and from 2015 to 2020. Meanwhile, sparse vegetation forest cover experienced a reduction in area from 2001 to 2015 and 2015 to 2020. In contrast to sparse vegetation, the moderate vegetation cover is experiencing a minor increase in area. Based on these results, relevant policymakers need to formulate policies to mitigate environmental impacts that may arise in the future.
Microalgal diversity assessment of Laguna Lake (Philippines) tributaries using Next-Generation Sequencing for water quality
Authors: SANTOS JOY ANN , MEJIA JULIUS AARON , GALARION M.A. JOWINA , VITAL PIERANGELI
Published: October 2023

Abstract. Santos JA, Mejia JA, Galarion MAJ, Vital P. 2023. Microalgal diversity assessment of Laguna Lake (Philippines) tributaries using Next-Generation Sequencing for water quality. Biodiversitas 24: 4636-4644. The species composition and density of microalgae have been successfully used as bioindicators of water quality as they respond quickly to any change in the water chemistry brought about by pollution. Laguna Lake in the Philippines, one of the country's most important hotspots for aquaculture, continues to be threatened by eutrophication, yet its microalgal profile has been understudied. The presence of microalgae, especially those identified to become causative agents of harmful algal blooms in lakes, can cause corresponding health effects in humans and the environment. This study determined microalgal diversity in samples from tributaries of Laguna Lake, Philippines, through 18S rRNA metagenomic sequencing or Next-Generation Sequencing (NGS). Out of the five sampling sites, only two sites passed the NGS quality control pipeline. Chlorella M.Beijerinck, dominated the eukaryotic microbial population in the Alabang-Cupang River sample, which is 95% of the total population. While in the Biñan River sample, relevant species found were Cyclotella scaldensis Muylaert & Sabbe, Teleaulax acuta (Butcher) Hill, Cryptomonas curvata Ehrenb., and Peridiniopsis penardii (Lemmerm.) Bourr. This is the first study to use NGS to detect microalgae in Laguna Lake and warrants further elucidation of the microalgal population through increased sampling efforts in other recreational and livelihood hotspots. Furthermore, the study results open the importance of implementing new schemes for water quality assessments focused on molecular-based approaches.
Bean-counting research and the mismanagement of knowledge production in business schools
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Authors: Agafonow Alejandro , Perez Marybel
Published: October 2023

Notorious cases of corporate misconduct often revolve around the misapplication of pay to performance. Yet many business schools have too easily given themselves up to these kinds of high-powered incentives in the management of research. This practice is contrary to the very management knowledge taught in business school classrooms and it can wreak havoc with business schools’ mission of knowledge production. The reduction of managing research to a bean-counting performance evaluation, that is, keeping count of discrete units of research outputs as A-class journal hits and citation counts, has arguably tilted the scales in favor of form and against content. This undermines both the quality of knowledge produced and the autonomy that academics need to create knowledge. Much as combat sports, football or soccer, and democratic societies prevent certain traits and actions from conferring an unfair advantage, academics need to reclaim the principle of a level playing field to prevent practices inimical to the academic enterprise.
Variable renewable energy penetration impact on productivity: A case study of poultry farming
Authors: Dupas Marie-Cécile , Parison Sophie , Noel Vincent , Chatzimpiros Petros , Herbert Éric
Published: October 2023

Like all current industrial systems, agriculture overwhelmingly relies on energy supply from controllable sources, mainly fossil fuels and grid electricity. Power supply from these sources can be adapted to perfectly match the timing of power requirements of demand systems. The energy transition largely consists in substituting renewable power—which is intermittent by nature—to controllable sources, leading to disconnection between instantaneous power production and demand. Energy storage is a potential solution for balancing production and demand and safeguarding the operating conditions of the demand system. In this paper we quantify the effects of renewable power supply (solar and wind) on the operation of a standard poultry farm. We model the balance of power generation and demand considering the growth conditions of poultry and local weather data including temperatures, wind speed and solar radiation. We assess scenarios of renewable power supply in function of the size of the power plant, the wind-to-solar power generation mix and energy storage, and assess the impact of power supply patterns on the operating intensity (productivity) of the demand system. We show that, with a limited storage capacity, it is possible to achieve non-negligible shares of renewable power penetration without major loss in farm productivity. However, a full transition to renewable power would require the combination ofi)-large energy storage compared to the annual demand,ii)- significant oversizing of the power production plant, andiii)-the exclusion of power generation combinations (wind/solar) that deviate from the timing of demand. Storage and power plant oversizing is all the more critical as production and demand are uncorrelated over the year. The ratio of useful to unused energy storage by the end of the year varies with the energy mix and operating intensity (productivity) of the farm. We discuss the implications of different energy configurations on the performance of the demand system.
Prevention as a Factor of Economic Sustainability of Workplace Accident Insurance Programs
Authors: Abikenova Sholpan K. , Nasyrova Gulmira A. , Shayakhmetova Aizhan G. , Sarybayeva Inara E.
Published: October 2023

In the scientific article, the positive impact of preventive accident insurance programs in the workplace is studied. Such programs are the most common and strategically significant type of social security in many countries. Insurance programs often include medical services, vocational rehabilitation, and benefits for injured workers or family members of deceased breadwinners. However, considering current trends, preventive measures aimed at stimulating the improvement of working conditions and occupational safety, active support, and funding of informational and preventive measures remain relevant. The article provides an overview of the use of preventive measures in insurance programs and suggests improving their effectiveness in enhancing working conditions. Firstly, it is proposed to create a unified information database for monitoring insurance contracts, controlling insurance flows on an industry-specific basis, for each enterprise and specific profession, as well as supervising the completeness and quality of preventive measures and the timely provision of compensation to injured workers and rehabilitation measures. Secondly, within the framework of assessing insurance risk, it is suggested to implement comprehensive assessment of occupational risk through the insurance fund. The results of the occupational risk assessment will serve as the basis for applying a two-component insurance tariff, taking into account a surcharge if the working conditions are unsafe. Thirdly, it is proposed to provide occupational health and safety training through insurance financing.

Keywords: safe work, risk-oriented approach, insurance, industrial accident, prevention.
Truth in Criminal and Civil Proceedings: Ensuring Sustainable Development of Society and Social Peace
Authors: Kudeikina Inga , Kaija Sandra
Published: October 2023

The right to a fair trial is a key element of the rule of law. It should be noted that the right to a fair trial has a complex structure, because securing this right is both a goal, or a state’s positive commitment to ensuring citizens’ rights, and a means of achieving this goal. The obligation to tell the truth as a principle of procedure constitutes the core of a fair trial. The concept of ‘fair trial’ would be a mere fiction if the state would not demand that parties to the case tell the truth in proceedings. There is no doubt that a dispute can be solved in reliance on true facts, true statements. This is a pre-requisite for the legal resolution of disputes, which means confidence in the judiciary as an element of state’s sustainability in the long run. The objective of the research is to examine the scope of the obligation to tell the truth in procedural relations in conjunction with the need for the fair settlement of legal relationships in the context of the sustainability of society in order to formulate suggestions for improving the legislation, thereby minimising opportunities to avoid the truth for the parties to proceedings.The research has employed descriptive and analytical, deductive and inductive methods. These methods have been used to analyse laws and the opinions of legal scholars and formulate conclusions and suggestions.

Keywords: civil proceedings, criminal proceedings, obligation to tell the truth
Additional 30-Second Observation of the Right-Sided Colon for Missed Polyp Detection With Texture and Color Enhancement Imaging Compared with Narrow Band Imaging: A Randomized Trial
Authors: Yoshida Naohisa , Inagaki Yoshikazu , Inada Yutaka , Kobayashi Reo , Tomita Yuri , Hashimoto Hikaru , Dohi Osamu , Hirose Ryohei , Inoue Ken , Murakami Takaaki , Morimoto Yasutaka , Okuyama Yusuke , Morinaga Yukiko , Itoh Yoshito
Published: October 2023

INTRODUCTION:

The efficacy of texture and color enhancement imaging (TXI) in the novel light-emitting diode endoscopic system for polyp detection has not been examined. We aimed to evaluate the noninferiority of the additional 30-second (Add-30-s) observation of the right-sided colon (cecum/ascending colon) with TXI compared with narrow band imaging (NBI) for detecting missed polyps.

METHODS:

We enrolled 381 patients ≥40 years old who underwent colonoscopy from September 2021 to June 2022 in 3 institutions and randomly assigned them to either the TXI or NBI groups. The right-sided colon was first observed with white light imaging in both groups. Second, after reinsertion from hepatic flexure to the cecum, the right-sided colon was observed with Add-30-s observation of either TXI or NBI. The primary endpoint was to examine the noninferiority of TXI to NBI using the mean number of adenomas and sessile serrated lesions per patient. The secondary ones were to examine adenoma detection rate, adenoma and sessile serrated lesions detection rates, and polyp detection rates in both groups.

RESULTS:

The TXI and NBI groups consisted of 177 and 181 patients, respectively, and the noninferiorities of the mean number of adenomas and sessile serrated lesions per patients in the second observation were significant (TXI 0.29 [51/177] vs NBI 0.30 [54/181], P < 0.01). The change in adenoma detection rate, adenoma and sessile serrated lesions detection rate, and polyp detection rate for the right-sided colon between the TXI and NBI groups were not different (10.2%/10.5% [P = 0.81], 13.0%/12.7% [P = 0.71], and 15.3%/13.8% [P = 0.71]), respectively.

DISCUSSION:

Regarding Add-30-s observation of the right-sided colon, TXI was noninferior to NBI.
Práticas discursivas do/no Pensamento de vida LGBT+
Authors: Araújo San Thiago de , Hashiguti Simone Tiemi
Published: October 2023

Conforme proposto por Silva (2022), o Pensamento de vida LGBT+ é um universo sociodiscursivo que funciona como um regime doutrinário colocando em circulação os saberes de indivíduos que se autodenominam LGBT+ e materializa-se em diferentes semioses utilizadas nas atividades comunicativas desses sujeitos. Partindo desse conceito orientador, neste artigo tomamos um trecho de vídeo disponível no canal Põe na Roda, do YouTube, como exemplar de funcionamento desse pensamento de vida e apresentamos uma análise dos efeitos de sentido e das condições de possibilidade do que nele se enuncia. Fundamentamo-nos nos estudos discursivos propostos por Michel Foucault e Michel Pêcheux, a partir dos quais entendemos os procedimentos analítico-discursivos e a relação com o dizer que é possível num pensamento específico. Como será exposto, a análise nos permite refletir sobre a vida sociocultural dos sujeitos LGBT+ e perceber saberes inerentes às especificidades de suas interações comunicativas.
algoritmo como materialidade discursiva em um contexto de educação linguística
Authors: Hashiguti Simone Tiemi , Fagundes Isabella Zaiden Zara
Published: October 2023

Baseamo-nos na revisão de estudos sobre casos de opressão e problemas sociais causados por algoritmos e em nossas orientações teóricas sobre educação linguística e processos de produção de sentidos para apresentar um prospecto de análises discursivas que realizaremos no sistema de inteligência artificial de um laboratório virtual para aprendizagem de línguas em construção. Conceitualmente, propomos refletir sobre o algoritmo como materialidade que, tal como a língua, pode funcionar como estrutura de discurso. Metodologicamente, apontamos como a análise discursiva sobre dados e algoritmos se dará. Este artigo contribui para a área de educação linguística ao chamar a atenção para a necessidade de abordar crítica e tecnicamente o uso das tecnologias computacionais dentro e fora da sala de aula de línguas e, para a área de ciências da computação, ao apontar para a importância da consideração, na prática de programação, dos aspectos da linguagem humana.
Toada, abrigo da poesia
Authors: Azevedo Kenedi Santos
Published: October 2023

A relação e o afastamento entre música e poesia têm gerado discussões no decorrer dos séculos, principalmente quando se pensa que, na antiguidade clássica, a poesia não tinha a autonomia angariada na modernidade. Esse fato começa a ser retomado na contemporaneidade, quando ocorre novamente o flerte entre esses gêneros. Sendo assim, o intuito deste trabalho é verificar de que modo a poesia se infiltra nas toadas de Ronaldo Barbosa, por meio de técnicas de composição, temas desenvolvidos e discurso lírico, a ponto de se dizer que essas músicas são “poesias caboclas”, escritas num ato de “inspiração”. Para tanto, são acionados teóricos, filósofos e ensaístas que tratem dessa relação e aqueles que mostram a definição desses gêneros, dentre os quais Aristóteles, com a Poética clássica, Giuliana Ragusa e seu Lira grega: antologia de poesia arcaica, Carlos Reis e o ensaio O conhecimento da literatura, sem interditar outros pesquisadores e pensadores dessa temática.
Entrevista com Júlio de Araújo Gurgel
Authors: Gurgel Júlio de Araújo , Villela Henrique Mascarenhas , Graf Simon , Vaid Nikhlesh
Published: October 2023

O Dr. Júlio Gurgel é um clínico de renome, com um interesse especial em Ancoragem Esquelética. O seu entusiasmo em ensinar e publicar nessa área da Ortodontia é aclamado e apreciado mundialmente. Ele realizou sua formação em Ortodontia e doutorado na Universidade de São Paulo, entre 1992 e 1999, e mais tarde fez o pós-doutorado na Faculdade de Medicina da Universidade do Texas (Houston, EUA). É professor da Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP) e de outras universidades no Brasil. É membro do Conselho Editorial da Revista Ciências Odontológicas e revisor de 12 revistas internacionais e nacionais.
Expansor maxilar de Haas modificado para interceptação de mordida cruzada anterior e posterior em paciente Classe III esquelética
Authors: Machado Andre Wilson
Published: October 2023

INTRODUÇÃO: As mordidas cruzadas anteriores e posteriores podem ser tratadas por diversas técnicas e são más oclusões bastante abordadas na literatura. Porém, o tratamento de pacientes com ambas as mordidas cruzadas é pouco documentado. OBJETIVO: O presente artigo apresenta o caso clínico de uma criança, na dentição decídua, com mordida cruzada posterior e anterior, associada a padrão esquelético de Classe III. O tratamento proposto consistiu no uso do aparelho expansor maxilar de Haas associado a molas digitais. RESULTADOS: Os resultados clínicos foram excelentes e o controle de cinco anos e sete meses demonstrou não só a eficácia da mecânica adotada, mas também, a sua estabilidade.
As seis chaves para aprimorar a precisão de um setup para alinhadores
Authors: Drumond André
Published: October 2023

INTRODUÇÃO: A construção de um setup digital para alinhadores envolve vários detalhes importantes e de responsabilidade do ortodontista. Definir a movimentação dos dentes no software exige uma série de competências únicas que vão além da habilidade no uso de programas de computador. Um setup baseado unicamente no encaixe virtual dos dentes e desconsiderando informações clínicas, aspectos da estética do sorriso, limites biológicos e os mecanismos de ação das forças ortodônticas irá predispor o tratamento ao insucesso. OBJETIVOS: Apresentar questões relevantes e discutir soluções, usando ferramentas digitais, visando aprimorar a precisão dos setups para alinhadores. CONCLUSÃO: O cuidado com a reprodução das condições clínicas atuais do paciente, a integração dos modelos digitais com outros exames, a incorporação da dinâmica funcional aos modelos digitais, e uma criteriosa execução dos movimentos dos dentes são importantes elementos adicionais ao setup digital, e transformam os simples modelos digitais, criados em um ambiente 3D aleatório de software, em um verdadeiro paciente virtual.
TCL1A+ B cells predict prognosis in triple-negative breast cancer through integrative analysis of single-cell and bulk transcriptomic data
Authors: Hou Peifeng , Luo Yang , Wu Ningzi
Published: September 2023

Triple-negative breast cancer (TNBC) is an aggressive subtype with limited treatment options and high mortality rates. It remains a prevailing clinical need to distinguish whether the patient can benefit from therapy, such as chemotherapy. By integrating single-cell and global transcriptome data, we have for the first time identified TCL1A+ B cell functions that are prognostically relevant in TNBC. This finding broadens the perspective of traditional tumor-infiltrating lymphocytes in predicting survival, especially the potential value of B cells in TNBC. Single-cell RNA-seq data from five TNBC patients were collected to identify the association between immune cell populations and clinical outcomes. Functional analysis was according to gene set enrichment analysis using pathways from MsigDB. Subsequently, the gene signature of TCL1A+ B cells based on differential expression genes of TCL1A+ B cells versus other immune cells was used to explore the correlation with tumor microenvironment (TME) and construct a prognostic signature using a non-parametric and unsupervised method. We identified TCL1A+ B cells as a cluster of B cells associated with clinical outcomes in TNBC. Functional analysis demonstrated its function in B cell activation and regulation of immune response. The highly enriched TCL1A+ B cell population was found to be associated with a thermal TME with anti-tumor effects. A high abundance of TCL1A+ B cell population is positively correlated with a favorable therapeutic outcome, as indicated by longer overall survival. The present study suggests that TCL1A+ B cells play a key role in the treatment and prognostic prediction of TNBC, although further studies are needed to validate our findings. Moreover, the integration of transcriptome data at various resolutions provides a viable approach for the discovery of novel prognostic markers.
Microbiological transglutaminase: Biotechnological application in the food industry
Authors: Kolotylo Vitaliy , Piwowarek Kamil , Kieliszek Marek
Published: September 2023

Microbial transglutaminases (mTGs) belong to the family of global TGs, isolated and characterised by various bacterial strains, with the first being Streptomyces mobaraensis. This literature review also discusses TGs of animal and plant origin. TGs catalyse the formation of an isopeptide bond, cross-linking the amino and acyl groups. Due to its broad enzymatic activity, TG is extensively utilised in the food industry. The annual net growth in the utilisation of enzymes in the food processing industry is estimated to be 21.9%. As of 2020, the global food enzymes market was valued at around $2.3 billion USD (mTG market was estimated to be around $200 million USD). Much of this growth is attributed to the applications of mTG, benefiting both producers and consumers. In the food industry, TG enhances gelation and modifies emulsification, foaming, viscosity, and water-holding capacity. Research on TG, mainly mTG, provides increasing insights into the wide range of applications of this enzyme in various industrial sectors and promotes enzymatic processing. This work presents the characteristics of TGs, their properties, and the rationale for their utilisation. The review aims to provide theoretical foundations that will assist researchers worldwide in building a methodological framework and furthering the advancement of biotechnology research.
Diagnostic performance of automated red cell parameters in predicting bone marrow iron stores
Authors: Paabo Triin , Mihkelson Piret , Beljantseva Jelena , Rähni Ain , Täkker Signe , Porosk Rando , Kilk Kalle , Reimand Katrin
Published: September 2023

Objectives

The aim of the study was to determine the diagnostic performance of novel automated red cell parameters for estimating bone marrow iron stores.

Methods

The study was a retrospective single-centre study based on data from an automated haematology analyser and results of bone marrow iron staining. Red cell parameters were measured on a Sysmex XN-series haematology analyser. Bone marrow iron stores were assessed semiquantitatively by cytochemical reaction according to Perls.

Results

The analysis included 429 bone marrow aspirate smears from 393 patients. Median age of patients was 67 years, 52 % of them were female. The most common indication for bone marrow examination was a plasma cell dyscrasia (n=104; 24 %). Median values of percentage of hypochromic and hyperchromic red blood cells (%HYPO-He, %HYPER-He), reticulocyte haemoglobin equivalent (RET-He) and microcytic red blood cells (MicroR) were statistically significantly different between cases with iron deplete and iron replete bone marrow. In a logistic regression model, ferritin was the best predictor of bone marrow iron stores (AUC=0.891), outperforming RET-He and %HYPER-He (AUC=0.736 and AUC=0.722, respectively). In a combined model, ferritin/MicroR index achieved the highest diagnostic accuracy (AUC=0.915), outperforming sTfR/log ferritin index (AUC=0.855).

Conclusions

While single automated red cell parameters did not show improved diagnostic accuracy when compared to traditional iron biomarkers, a novel index ferritin/MicroR has the potential to outperform ferritin and sTfR/log ferritin index for predicting bone marrow iron stores. Further research is needed for interpretation and implementation of novel parameters and indices, especially in the context of unexplained anaemia and myelodysplastic syndromes.
Auditivierung des textkritischen Apparats
Authors: Cividini Iacopo
Published: October 2023

Since their emergence in the 19th century, the aim of critical editions has not only been to publish philologically reliable texts, but also to make the decisions on the basis of the editorial process as transparent as possible. In the specific case of the music edition, however, the formulation of editorial decisions in a critical apparatus is complicated by the semiotic discrepancy between the sign system of musical text and its verbalised annotation in the fundamentally different sign system of linguistic text. This unbridgeable medial gap between the musical text and its verbal account caused the original editorial object to be split apart within printed editions of the 20th century: between the edited text and the critical report on the one hand, and again between practical editions for the general public and scholarly editions for the small circle of qualified musicologists on the other hand.

Using the Digital Mozart Edition as an example, this article shows how a digital format can, through its audio-visual multimedia, both create spaces for the integration of the critical apparatus into the edited text and enable a ‘deverbalization’ of the critical vocabulary that conveys the documentation of editorial decisions in musical form more intuitively and more precisely. The digital medium makes it possible for critical editions of music to come closer to the ideal of an open edition in the sense of an ‘edition of the edition’, in which not only the text itself, but also the editorial process that led to this text is, in turn, edited and made immediately accessible to the user.
Kleider machen Leute
Authors: Busch Nathanael
Published: October 2023

The appraisal and evaluation of the 16th century poet Hans Sachs is dominated by stereotypes and often made without knowledge of the texts. The edition of the complete works edited by Adelbert von Keller and Edmund Goetze (1870–1908), which is still in use today, perpetuates these stereotypes and devalues the poet. On the groundwork of various aspects (order, paratexts, variance, errors, normalisation), objections to the edition are discussed and suggestions are made as to what a new edition should look like.
Pörtner & Wühr: Spuren des Original-Ton-Hörspiels zwischen Wuppertal und München
Authors: Lukas Wolfgang , Machwitz Dana , Politycki Bastian
Published: October 2023

The Wuppertal exhibition Pörtner & Wühr: Spuren des Original-Ton-Hörspiels zwischen Wuppertal und München, which was shown from November 2022 to January 2023 in the University Library of Wuppertal represented an attempt to provide an insight into the production workshop of two pioneers of original tone radio plays, Paul Pörtner (1925–1984) and Paul Wühr (1927–2016). Selected handwritten and typewritten documents from the bequests of the two authors made the genesis and production aesthetics vivid. The analogue exposition was complemented by a media station that offered an additional digital exhibition space for in-depth exploration.
50 Jahre Texte und Varianten
Authors: Martens Gunter
Published: October 2023

In 1971, more than 50 years ago, the anthology Texte und Varianten was published by C. H. Beck in Munich. Gunter Martens, who edited the volume together with the Swiss philologist Hans Zeller, recalls in this article the background to the preparation of this historical monument of scholarly editing. With quotations from the minutes of two colloquia, organized by the Deutsche Forschungsgemeinschaft in Bad Godesberg in October 1967 and in Marbach am Neckar in May 1968, and excerpts from letters of the two editors, the article documents the reasons that led to the anthology.