bluuebunny/crossref_metadata_2025 huggingface dataset:
Майбутні вчителі на шляху до культурної трансмісії засобами музичного фольклору: результати фокус-дослідження
Authors: Кісєль Мірослав , Ніколаї Галина
Published: January 2025

Метою статті є презентація думок майбутніх учителів, які набувають етнокультурної та методичної компетентностей щодо трансляції культури через ресурси музичного фольклору. Міркування ґрунтувалися на результатах аналізу вибраної літератури з теми та звітів фокус-групи. Представлені дослідження є продовженням і доповненням до раніше розпочатого спільного дослідження теоретичних основ розв’язання означеної проблеми. Привернуто увагу до сучасного виміру музичного фольклору та явища культурної трансмісії з наголосом на освітньому вимірі. В емпіричній площині подано висловлювання студентів педагогічних факультетів університетів Польщі та України, що вказують на їхній підхід до музичного фольклору та передачі культурних елементів у формі установок, цінностей, вірувань і моделей поведінки, а також навчання через них. Зроблено спробу розглянути їх у контексті набуття студентами етнокультурної та методичної компетентностей. У роботі зазначено цінні педагогічні та художні рішення прикладної пошукової діяльності. Дослідницький проєкт проводився з використанням стратегії якісних досліджень. На теоретичному рівні використовувався аналіз відповідної літератури, а на емпіричному увагу було зосереджено на прямому спостереженні й опитуванні. Результатом теоретичних та емпіричних розвідок стала презентація феномену культурної трансмісії засобами музичного фольклору крізь призму вибраної літератури та ідентифікація респондентів у сфері музичного фольклору за національною ознакою. Усвідомлена рефлексія над явищами рідної культури допомагала учасникам дослідження зрозуміти своїх ближчих і далеких сусідів, започаткувати творчий діалог у дусі прийнятного різноманіття. Усвідомлення феномену міграції населення змусило респондентів по-новому поглянути на проблему культурної трансмісії з позиції локального, національного, європейського та глобального контекстів. Музичний фольклор, що функціонує в актуальному соціальному просторі на основі окресленої культурної трансмісії, викликав у респондентів різні рефлексії, пов’язані зі спогадами про попередній родинний, шкільний, медійний і громадський досвід, а також зі спостереженнями за мінливою реальністю в умовах воєнної загрози. Участь у фокус-групах стала поштовхом для подальшої діяльності щодо набуття етнокультурної та методичної компетентносте.
Development of metrorythmic skills of beginner students in the process of learning percussion instruments
Authors: Levytska Iryna Mykolaivna
Published: January 2025

The article aims at highlighting the theoretical and methodical aspects of developing metrorhythmic abilities of beginner students in the process of learning to play percussion instruments. The research methodology chosen for this aim included theoretical (analysis, synthesis, abstraction and generalization) and empirical (pedagogical observation) methods. The essence of key concepts, including “abilities”, “musical abilities” and “metrorhythmic abilities” have been considered. Metrorhythmic ability is defined as the basic unity of musical performance, providing the ability to perceive, interpret, and perform musical works with precision, expressiveness, and technical skills. It was revealed that metrorhythmic abilities are formed in ontogenesis gradually, from basic to more complex elements: from feeling the tempo to operating complex rhythmic patterns. Special attention is paid to the role of rhythm in performance on percussion instruments, where it acts as a formative element of musical material, regulating its movement in time. Methodical approaches aimed at the development of metrorhythmic abilities of beginner students are considered, in particular, practical, reproductive, visual-auditory and problem-based methods. A significant role in the educational process is given to improvisation, which contributes to the development of rhythmic sensitivity, technical skills, creative thinking and the ability to integrate individual interpretations into performance. The essence of creative tasks aimed at the development of emotional response, associative thinking and an independent approach to working with musical works is revealed. It is emphasized that the active musical activity of students, which includes performing rhythmic exercises, analyzing works of various genres and styles, using improvisation and interpretive approaches, is the basis of effective learning. Such methods allow students to develop technical, creative and analytical skills that ensure the success of musical performance on percussion instruments.
The Rise of Aging Influencers: Exploring Aging, Representation, and Agency in Social Media Spaces
Authors: Shao Yang , Yin Qingxia
Published: January 2025

Objective: This study investigates the rise of aging influencers on social media, aiming to understand their roles in reshaping societal perceptions of aging, promoting inclusivity, and bridging generational divides.
 
Theoretical Framework: The research is grounded in theories of ageism, the social construction of aging, and the attention economy. These frameworks provide a robust foundation for analyzing how digital platforms mediate representations of aging and influence societal narratives.
 
Method: A systematic literature review was conducted using databases such as Scopus, Google Scholar, and CNKI. The review synthesizes findings from 10 studies published between 2015 and 2024. Thematic analysis identified recurring patterns in content strategies, representation, and audience engagement.
 
Results and Discussion: Aging influencers challenge ageist stereotypes by emphasizing vitality, creativity, and resilience, while also facing pressures from commercialization and algorithm-driven visibility. Cultural variations reveal that Western influencers often highlight individuality, while those in collectivist societies emphasize family and community values. Challenges include marginalizing diverse experiences of aging and ethical concerns regarding influencer autonomy.
 
Research Implications: The study highlights the potential for aging influencers to advocate for systemic change, promote healthy aging, and inspire intergenerational dialogue. It suggests practical applications in policy development, marketing strategies, and public health initiatives.
 
Originality/Value: By synthesizing current research, this study contributes to the emerging discourse on aging influencers, emphasizing their unique role in fostering age inclusivity and redefining digital engagement across generations.
Editorial
Authors: Zalamea Patricia
Published: January 2025

Editorial note for H-ART's issue 19.
La historia del arte en Colombia y sus lugares de enunciación
Authors: Vanegas Zubiría Carlos Mario
Published: January 2025

Editorial note by Carlos Vanegas Zubiría, guest editor and member of the Comité Colombiano de Historiadores del Arte (CCHA).
La construcción de la biografía de artista en el Papel Periódico Ilustrado: Espinosa, Groot, Matís y Torres Méndez
Authors: Toro Henao Diana Carolina
Published: January 2025

This article aims to study four biographical narrations published in Papel Periódico Ilustrado (1881-1187): José María Espinosa, José Manuel Groot, Francisco Javier Matís, and Ramón Torres Méndez, in order to examine how the image of the artist is configured in this relevant nineteenth-century journal that played a pivotal role in Colombia's cultural, literary, and artistic history. The research focuses on the analysis of portraits attached to the texts, the definition of artistic work, education, honors, and awards.
Curar estereotipos. Institucionalidad, turismo e imagen digital en El artista y la fotografía de Joan Fontcuberta
Authors: Soler Reyes Cristian
Published: January 2025

In this work I analyze The Artist and the Photograph, an artwork by Joan Fontcuberta. In the first part, I examine the strategies that Fontcuberta employs, in his purported role as a curator, to create a narrative for the images he is presenting. Secondly, I consider how these exhibitions turn the art of a few artists of Catalan origin into an art that represents the Spanish nation as a whole. Finally, I analyze how Fontcuberta infiltrates various cultural institutions to reflect on the role they play and how they relate to other social phenomena, such as tourism and the entertainment industry.
GRANULOMATOUS ROSACEA. THE EXPERIENCE IN THE TREATMENT OF THE PATIENTS.
Authors: Gallyamova Yulia
Published: January 2025

Granulomatous rosacea is a rare variant of rosacea, which is characterized by a special clinical picture and approaches to patient management that differ from traditional rosacea. The clinical picture of granulomatous rosacea is represented by the monomorphic papules, which tends to be yellow on dermotoscopy. Treatment of this variant of rosacea is difficult, the first-line therapy of rosacea is ineffective. The article presents two cases of granulomatous rosacea similar in clinical picture, gender and age of patients, but with different approaches of treatment. Both patients were prescribed therapy with 0.1% tacrolimus ointment 2 times a day for a month, 10 procedures of photodynamic therapy. One of the patients was planning a pregnancy, in which case treatment with isotretinoin was excluded, and the other patient agreed to systemic therapy with isotretinoin. Systemic isotretinoin has been shown to be effective in a patient with granulomatous rosacea and it has been achieved long-term remission at a dose of less than 0.2 mg/kg body weight for 6 months.
Internet Addiction as Predictor in Marital Relationship among a Sample of Divorced Women
Authors: Harahsheh Ahmad Hasan Muhareb
Published: January 2025

This study investigates the predictive relationship between Internet addiction and marital incompatibility among a sample of divorced women. Given the rapid technological advancements and the pervasive influence of the Internet on marital compatibility, this research examines the extent to which Internet addiction serves as a predictor for marital enhancers and inhibitors of compatibility. Utilizing a sample of 123 divorced women, the study employs the Internet Addiction Scale (IAS) (Cronbach’s alpha= .86) and the Marital Compatibility Inhibitors and Enhancers Scale (MCIES) (Cronbach’s alpha= .76, .72, respectively). The findings reveal a high prevalence of Internet addiction (M=4.23, SD=.57), elevated levels of inhibitors (M=4.18, SD=.64) affecting marital adjustment, and a diminished presence of enhancers (M=1.75, SD=.60) promoting marital compatibility. Statistical analysis demonstrates significant and robust correlations between Internet addiction and both marital adjustment inhibitors (r = .789) and enhancers (r = -.991) among divorced women. Furthermore, Internet addiction accounts for 61.9% of the variance in inhibitors and negatively correlates with 98.2% of the variance in enhancers. The study concluded that the Internet addiction affects the marital relationship, and thus negatively affecting the cohesion of the family and society.
O impacto da terapia de reposição hormonal na saúde cognitiva de mulheres pós-menopausa
Authors: Motta Julia Magalhaes , Almeida Beatriz Caroline Pazzini de , Carvalho Déborah Batista de , Mendes Laura Andrade , Calixto Marcela Rotband , Francisquine Maria Eduarda D’Avila , Santos Mila Schiavini Beiriz , Aranda Osvaldo Luiz
Published: January 2025

Objetivo: O objetivo do presente estudo foi analisar o impacto da Terapia de Reposição Hormonal (TRH) sobre a saúde cognitiva de mulheres pós-menopausa. Métodos: Para esse fim, foi utilizado um compilado de pesquisas bibliográficas de abordagem qualitativa e caráter descritivo, por meio de uma revisão integrativa da literatura em periódicos indexados nas bases de dados PubMed e LILACS. Resultados: Os resultados demonstraram que a TRH, quando iniciada na perimenopausa ou em seu período inicial, está relacionada à melhoria no desempenho em vários campos do domínio cognitivo, sobretudo acerca do déficit cognitivo, fluência verbal, memória e velocidade psicomotora, contudo, se utilizada a curto e médio prazo. Em contrapartida, evidenciaram possíveis impactos negativos em mulheres já menopausadas e idosas. Considerações finais: Desse modo, os estudos apontam relação entre a saúde cognitiva da mulher pós-menopausa e a TRH, sendo esta, benéfica quando de início precoce e possivelmente maléfica quando instituída tardiamente, sendo necessários mais estudos que comprovem esta relação.
Hesitação e recusa vacinal entre profissionais da saúde
Authors: Siqueira Vinicius de Oliveira , Baitelo Caio Biazoto , Rocha Aline Marques Perez da , Santos Giovanna Villar dos , Aranha Ana Beatriz Reis , Simarelli Mariana Malagô Gerola , Milagres Maria Alice Santana , Cressoni Valéria Dulce , Meira Denilson Guimaraes , Milagres Clarice Santana
Published: January 2025

Objetivo: Analisar a hesitação e recusa vacinal entre os profissionais de saúde. Métodos: Trata-se de uma revisão de literatura integrativa com artigos publicados entre os anos de 2017 e 2023. Foram utilizadas as bases de dados eletrônicos PubMed e Scielo, sendo empregados os seguintes descritores em inglês e português para a seleção primária dos artigos: “refusal to vaccination” (“recusa vacinal”), “health professionals” (“profissionais da saúde”), “vaccination refusal" (“recusa vacinal”), hesitation (hesitação), vaccination (vacinação). Resultados: Foram avaliados 8 artigos que atenderam aos critérios propostos. Predominaram estudos realizados na Itália e no Canadá.  Quanto ao ano de publicação, o ano de 2022 e 2019 apresentaram juntos, metade dos trabalhos analisados na presente revisão. Todos os artigos incluídos na presente revisão possuem metodologia de análise transversal, com utilização de questionário semiestruturado e entrevistas para obtenção dos dados. Considerações finais: Os trabalhadores da saúde apresentam importante papel ao desempenharem ações na promoção e na aceitação das vacinas. Contudo, também estão sujeitos à hesitação e recusa vacinal, especialmente após o advento da pandemia da covid-19, uma vez que são o principal público influenciador de decisões sobre a imunização.
O manejo da intoxicação por opioides na emergência e formas de prevenção
Authors: Carvalho Alícia de Alencar , Suzuki Érica Harumi Kanai , Santos Gabriel Barbosa dos , Fruet Giovanna Santos , Mello Maria Luiza Felipe Rocha , Preta Maria Paula Goulart de Abreu Catta , Vasconconcelos Mariana Ribeiro Ramos Abdalla de , Bezerra Pedro Miranda Vieira , Simão Salma Sarkis , Juliani Alisson
Published: January 2025

Objetivo: Analisar as formas de manejo e prevenção da síndrome de intoxicação por opioides na emergência. Revisão bibliográfica: Os opioides são medicamentos indispensáveis nas terapias de controle da dor moderada a intensa que possuem efeito analgésico potente. Apesar disso, esses medicamentos podem acarretar alguns efeitos secundários graves que comprometem o bem-estar geral do paciente. Além disso, a prescrição inadequada pode gerar dependência química e síndrome de abstinência. A naloxona foi o medicamento mais utilizado para reverter a intoxicação por opioides, a qual foi desenvolvida na década de 1960 e foi o primeiro antagonista do receptor opioide a reduzir o sintoma clínico de depressão respiratória induzida, sem produzir efeitos agonistas do receptor. Considerações finais: O manejo da intoxicação por opioides apresenta a naloxona como um fármaco eficaz para o tratamento medicamentoso atual. Ademais, a abordagem preventiva pré-operatória constitui-se de uma abordagem eficiente para evitar uma possível intoxicação por opioides decorrente do uso incorreto, dependência ou pelo abuso de opioides formalmente prescritos por médicos.
To Study Level of Gonadal Hormone in Cancer Patients Receiving Chemotherapy
Authors: Meshram Ashok Asaram , Ranjan Subhash , Singhal Rajendra , Yegade Walmik Shrihari , Krishna Gopi Dummu
Published: January 2025

Objectives:

The objective of this study was to study the alteration in levels of testosterone, luteinising hormone (LH), follicle-stimulating hormone (FSH) and prolactin in male cancer patients’ post-chemotherapy who have been started on drugs causing grade III or more haematological toxicity requiring granulocyte colony-stimulating factor support.

Materials and Methods:

An open-labelled prospective single-centre study for the assessment of Gonadal dysfunction in male cancer patients on chemotherapy from August 2010 to October 2012.

Results:

Patients had a significant alteration in testosterone (23% n = 11), LH (52.08% n = 25), FSH (83.3% n = 40) and prolactin levels (22.92% n = 11) post-chemotherapy, which was statistically significant (P < 0.05). The high dose, as well as the low dose Cisplatin group, were associated with substantial gonadal dysfunction in testicular tumour patients. Hence, regimens using low-dose cisplatin at the cost of compromising the cure rate for the motive of preservation of fertility are not warranted. There was no statistically significant difference found in alteration in mean testosterone, mean LH or mean FSH Prolactin levels among cisplatin, cyclophosphamide or combined cisplatin and cyclophosphamide chemotherapy group, at least in the initial weeks of post-chemotherapy.

Conclusion:

There is a significant gonadal dysfunction in cancer patients receiving cytotoxic chemotherapy. Hence, increasing awareness to prevent, detect and treat expected long-term toxicities is crucial. Prechemotherapy cryopreservation of semen and assisted reproductive technologies are good options to describe the rate of involuntary infertility without affecting the survival of patients by decreasing doses of chemotherapy.
Instruments of the Joint Convention and the Potential for their Effective Use
Authors:   State Corporation “Rosatom”, Dorofeev A. N. , Makarchuk M. V. ,   State Corporation “Rosatom”, Dorogov V. I. ,   Nuclear Safety Institute of the Russian Academy of Sciences, Mamchits E. G. ,   Nuclear Safety Institute of the Russian Academy of Sciences, Samoilov A. A. ,   Nuclear Safety Institute of the Russian Academy of Sciences, Utkin S. S. ,   Nuclear Safety Institute of the Russian Academy of Sciences, Vasilishin A. L. ,   Federal State-Funded Institution Scientific and Technical Center for Nuclear and Radiation Safety, Ponizov A. V. ,   Federal State-Funded Institution Scientific and Technical Center for Nuclear and Radiation Safety
Published: January 2025

The article evaluates some additional benefits that can be potentially gained from the participation of Russian organizations in the events held within the framework of the Joint Convention on the Safety of Spent Fuel Management and on the Safety of Radioactive Waste Management. It presents proposals on how national achievements can be demonstrated and advanced international experience can be used by nuclear industry organizations during such events.
Computational study of radiation characteristics inherent in the reactor graphite from RBMK-1000 units
Authors:   JSC “All-Russian Research Institute for Nuclear Power Plants Operation”, Selkin S. S. , Sharov D. A. ,   JSC “All-Russian Research Institute for Nuclear Power Plants Operation”, Plekhanov R. V. ,   JSC “All-Russian Research Institute for Nuclear Power Plants Operation”, Zinakov D. L. ,   JSC “All-Russian Research Institute for Nuclear Power Plants Operation”
Published: January 2025

The paper focuses on a computational study seeking to estimate the radiation characteristics of reactor graphite from RBMK power units at their decommissioning stage based on the case study of Leningrad NPP and its unit №2. The calculations performed in the MCU-RBMK software via the Monte Carlo method were verified based on a data array with experimental specific activities of radionuclides found in the reactor graphite. The paper presents the estimated distribution of radioactive waste volumes represented by reactor graphite according to relevant waste categories with due account of amendments introduced into the radioactive waste classification system since January 1, 2024.
Comprehensive flowchart proposed to process the solution and the sediment parts of the accumulated HLW inventory of complex chemical composition from PA Mayak’s radiochemical production facilities
Authors:   FSUE “PА “Mayak”, Kozlov P. V. , Shaidullin S. M. ,   FSUE “PА “Mayak”, Markova D. V. ,   FSUE “PА “Mayak”, Logunov M. V. ,   FSUE “PА “Mayak”, Remizov M. B. ,   FSUE “PА “Mayak”, Lukin S. A. ,   FSUE “PА “Mayak”, Zubrilovsky E. N. ,   FSUE “PА “Mayak”
Published: January 2025

The paper presents a comprehensive multi-option flowchart proposed to process the accumulated HLW inventories of complex chemical composition describing the core processes, the characteristics of products formed at each processing stage and the relationship between the individual elements of the proposed flowchart. It specifies the process equipment (or its prototypes) to be introduced under the proposed flowchart. It presents the thresholds for the preliminary feasibility assessment of the processing options proposed for the solution and the sedimentary parts of the accumulated HLW inventories. The study demonstrates the feasibility of further efforts seeking to select optimal design options under the proposed flowchart.
Artificial Intelligence in Education: A Future Vision
Authors: Al-Areeshi Zohor Mohammed
Published: January 2025

The world we live in has been radically changed by technology in recent decades. The field of artificial intelligence (AI) in education (AIEd) has developed into a sizable literature collection with a variety of viewpoints. The use of artificial intelligence in educational applications is growing in popularity, posing both benefits and difficulties for the classroom. This study aims to provide a comprehensive understanding of the current conceptual framework of AIEd and explore the future vision for this technology. The study aims to investigate the opportunities that AI technology offers to enhance teaching and learning, identify challenges in this field and outline the future vision for AI technology, and examine the learning outcomes for teachers and students influenced by AI technology. This method can offer a thorough understanding of the conceptual framework and the long-term goals for this area of technology. For a comprehensive literature evaluation, we chose 35 empirical research publications that included AIEd applications, study themes, and other aspects of the research design, including the general AIEd research field, AIED applications, research topics, and future vision including future benefits, opportunities, threats, and challenges. Although AIEd-based settings are improving student learning, research indicates that tailored learning is still in its early stages. Lack of money and moral dilemmas are obstacles. AIEd's benefits include the fact that AI chatbots and applications facilitate learning, but they also have drawbacks. Additionally, AI apps improved engagement through interactive features, promoted well-being with components and continual availability, and spurred creativity by offering new ideas and problem-solving strategies. While encouraging creativity and increasing participation have many advantages, there are also important obstacles that need to be overcome, such as limits on creativity and moral dilemmas. To maximize the use of AI in education, these elements must be balanced through careful deployment and ongoing assessment.
معايير الجودة المقترحة في تطبيق نموذج الاستجابة للتدخل في برامج صعوبات التعلم من وجهة نظر أعضاء هيئة التدريس
Authors: آل دكين حنان حسين , السقاف علوية عبدالله
Published: January 2025

هدفت الدراسة الحالية إلى التعرف على معايير الجودة المقترحة لتطبيق المستويات الثلاثة من نموذج الاستجابة للتدخل في برامج صعوبات التعلم في المملكة العربية السعودية، والتعرف على تصورات ومعتقدات أعضاء هيئة التدريس في برامج التربية الخاصة حول الممارسات الأساسية التي تساهم في نجاح استخدام هذا النموذج. اتبعت الدراسة المنهج المختلط، حيث تم استخدام الاستبانة والمقابلة كأدوات لجمع البيانات. حيث طبقت الاستبانة على (32) عضو وعضوة هيئة تدريس في الجامعات السعودية، وأجريت المقابلة مع (3) عضو وعضوة هيئة تدريس من الجامعات السعودية. وتوصلت نتائج البيانات الكمية إلى وجود فروق ذات دلالة إحصائية بين متوسطات استجابات أفراد عينة الدراسة في ممارسة المعايير (الإعداد والتدريب – التخطيط) تعزى لمتغير الجنس لصالح الذكور، وعدم وجود فروق ذات دلالة إحصائية بين متوسطات استجابات أفراد عينة الدراسة نحو معيار (الإعداد والتدريب – التخطيط) تعزى للمتغيرات الآتية: (سنوات الخبرة – التخصص – المرتبة العلمية). اما نتائج البيانات النوعية فقد أظهرت اتفاق وجهات نظر المشاركين نحو أهمية حصول العاملين في نموذج الاستجابة للتدخل على الشهادات والخبرات اللازمة للإلمام بالنموذج، والأهمية البالغة التي قد يضيفها وجود لجنة استشارية للرجوع إليها في اتخاذ القرارات. وضرورة توفر دعم مادي وميزانية خاصة لتطبيق نموذج الاستجابة للتدخل وضرورة الحرص على الوصول بنموذج الاستجابة للتدخل لأفضل جودة ممكنة.
المبادئ التربوية المستنبطة من حوار النبي- ﷺ- مع زوجاته وتطبيقاتها في الأسرة المسلمة
Authors: المطيري نورة حمود
Published: January 2025

هدفت الدراسة إلى الكشف عن المبادئ التربوية المستنبطة من حوار النبي- ﷺ- مع زوجاته وتطبيقاتها التربوية في الأسرة المسلمة، واستخدمت المنهجين الاستنباطي والوثائقي، كان من أبرز نتائج الدراسة ما يلي: تمثلت المبادئ التربوية المستنبطة من حوار النبي- ﷺ- مع زوجاته فيما يلي: حسن الاستقبال والخطاب والاستماع، أهمية الدعم والمادي والمعنوي بين الزوجين، التأني وعدم الاستعجال، التحلي الصبر وضبط النفس، التخلق بالرفق والتودد والرحمة بين الزوجين، تجنب الإيذاء والعنف عند الغضب وتجنب الكلام الفاحش البذيء، حسن التواصل بين الزوجين، أدب الحوار باستخدام الألفاظ المحببة والمشوقة، أهمية التواصل العاطفي بين الزوجين، المبادرة في فتح الحوار مع شريك الحياة وتخصيص وقت للجلوس معه وتبادل الحوار، التشويق والجاذبية في الحوار، أهمية الصدق والصراحة بين الزوجين، أدب العتاب حال الخلاف، إظهار مشاعر الحب لشريك الحياة، الحب والاحترام والتقدير هو الأصل والغضب والكره شيء عارض، حفظ الود نهاية الحوار، مبدأ حسن العشرة بين الزوجين، مبدأ أهمية الترويح مع شريك الحياة والتحدث معه ومسامرته، مبدأ الرفق، مبدأ حسن الاستماع، مبدأ الحلم والصبر.
Expediting hit-to-lead progression in drug discovery through reaction prediction and multi-objective molecular optimization
Authors: Nippa David F. , Atz Kenneth , Stenzhorn Yannick , Müller Alex T. , Tosstorff Andreas , Benz Jörg , Binch Hayley , Bürkler Markus , Haider Achi , Heer Dominik , Hochstrasser Remo , Kramer Christian , Reutlinger Michael , Schneider Petra , Shema Thierry , Topp Andreas , Walter Alexander , Wittwer Matthias B. , Wolfard Jens , Kuhn Bernd , van der Stelt Mario , Martin Rainer E. , Grether Uwe , Schneider Gisbert
Published: January 2025

The rapid and economical synthesis of novel bioactive compounds remains a significant hurdle in drug discovery efforts. This study demonstrates an integrated medicinal chemistry workflow that effectively diversifies hit and lead structures, enabling an efficient acceleration of the critical hit-to-lead optimization phase. Employing high-throughput experimentation (HTE), we generated a comprehensive data set encompassing 13,490 novel Minisci-type C-H alkylation reactions. This data set served as the foundation for training deep graph neural networks to accurately predict reaction outcomes. Scaffold-based enumeration of potential Minisci reaction products, starting from moderate inhibitors of monoacylglycerol lipase (MAGL), yielded a virtual library containing 26,375 molecules. This virtual chemical library was evaluated using reaction prediction, physicochemical property assessment, and structure-based scoring, identifying 212 potential MAGL inhibitor candidates. Of these, 14 ligands were synthesized and exhibited subnanomolar activity, representing a potency improvement of up to 4500 times over the original hit compound. These compounds also displayed favorable pharmacological profiles. Co-crystallization of three computationally designed ligands with the MAGL protein provided valuable structural insights into their preferred binding poses. This study demonstrates the potential of combining miniaturized HTE with deep learning and molecular property optimization to reduce cycle times in drug discovery.
Deconjugative Photoisomerization of Cyclic Enones
Authors: Blank Lukas , Kim Jungwon , Daniliuc Constantin , Götzinger Alissa , Müller Marc-André , Schütz Jan , Wüstenberg Bettina , Gilmour Ryan
Published: January 2025

The deconjugative isomerization of α,β-unsaturated carbonyl compounds enables regioisomeric products to be forged with simultaneous Umpolung of alkene reactivity. Although highly enabling, the endergonic nature of the net process coupled with governing regioselectivity outcomes, renders it challenging. Innovations in the positional isomerization of linear species, often by light-triggered activation, have re-energized this area. However, the deconjugative isomerization of cyclic enones is underdeveloped and often associated with impractical reaction conditions, limited substrate scopes, and a lack of mechanis-tic clarity. Herein, we report an operationally simple photochemical isomerization of cyclic enones using near-UV (372 nm) irradiation with catalytic amounts of Brønsted acid (HCl). This platform enables exocyclic deconjugative isomerization of a diverse array of enones including α-isophorone (a key intermediate in a variety of industrial processes), terpenoids and ster-oids. Mechanistic studies reveal the pivotal role of the solvent as a key mediator in the isomerization, where sequential hy-drogen atom transfer (HAT) and reverse-HAT (RHAT) are proposed to be operational.
Exploring the Chemical Design Space of Metal-Organic Frameworks for Photocatalysis
Authors: Mouriño Beatriz , Majumdar Sauradeep , Jin Xin , McIlwaine Fergus , van Herck Joren , Ortega-Guerrero Andres , Garcia Susana , Smit Berend
Published: January 2025

In this work, we introduce a combined DFT and machine learning approach to obtain insights into the chemical design of metal-organic framework (MOF) photocatalysts for hydrogen (HER) and oxygen (OER) evolution reactions. To train our machine learning models, we evaluated a dataset of 314 MOFs using a dedicated DFT workflow that computes a set of five descriptors for both closed and open shell MOFs. Our dataset is composed of a diverse selection of the QMOF database and experimentally reported MOF photocatalysts. In addition, to ensure a balanced dataset, we designed a set of MOFs (CDP–MOF) inspired by insights obtained regarding different types of photocatalytic materials. Our machine-learning approach allowed us to screen the entire QMOF and CDP–MOF databases for promising candidates. Our analysis of the chemical design space shows that we have many materials with a suitable spatial overlap of electron and hole, band gap, band-edge alignment to HER, and charge-carrier effective masses. However, we have identified in the QMOF database only a very small percentage of materials that also have the right band edge alignment to OER. With the CDP–MOF database, we successfully targeted building blocks that potentially have the correct OER band alignment, and indeed obtained a larger percentage of materials that obey this criteria. Among those, a few motifs stood out, such as Au-pyrazolate, Ti clusters and rod-shaped metal nodes, and a particular MOF designed with the Mn4Ca cluster, which mimics the OER center in the photosystem II of photosynthesis.
SOME ISSUES OF COUNTERING THE LEGALIZATION (LAUNDERING) OF CRIMINAL INCOME, WITH SHADOW GENOMIC LABORATORIES SECTOR REVIEW
Authors:   AL-FARABI KAZAKH NATIONAL UNIVERSITY, Dossekeyev О.B. , Akimbayeva A.A. , Shalkharov Y.S. , Imanbekova M.M. , Nartay A.N.
Published: January 2025

In the article the authors consider the issues of severity of tracing of cash transactions, including the use of illegal financial systems Havala activity in the Republic of Kazakhstan. It is concluded that non-cash payments are beneficial for law-abiding citizens, and the use of cash for criminal elements, since the transfer of money from one hand to another is virtually impossible to trace, which favorably affects the development of "shadow economy". These elements of the shadow economy also include black markets, offshore zones, reverse mines, binary assets, as well as shadow biological, environmental and genomic laboratories, which are a generator of recharge and a catalyst for the turnover of shadow assets. Based on the general basis of these elements of the shadow economy, it is worth paying attention to the authors’ proposals. The authors propose to expand the scope of non-cash payments at the legislative level by providing various benefits for financial structures and their clients, as well as the need to legalize Havala. According to the authors, the punishment for legalization (laundering) of proceeds of crime is not commensurate with the act, in this regard, it is proposed to increase the sanction of the size of penalties in the Criminal Code of the Republic of Kazakhstan.
Border governance through local community empowerment: insights from Indonesia-Papua New Guinea borderline
Authors: Pakasi Usman , Faridz Muhammad , Majid Hasbi , Susilawati Susilawati
Published: January 2025

This research explored the empowerment of local communities in governing the border areas between Indonesia and Papua New Guinea. The research aims at strategies to improve community livelihoods through the development of agricultural infrastructure, increased productivity, food security, and community participation in decision-making. The research methodology used was a qualitative case study conducted in Kampung Mosso, on the Indonesia-Papua New Guinea borderline. Data was collected through interviews with local leaders and local residents, complemented by a review of government reports and policies, NGO documents, and other academic sources. Analysis will utilize NVivo software for systematic coding and evaluation. Research findings showed that agricultural infrastructure development receives the highest allocation in community empowerment efforts, followed by education and training, and community participation. The research emphasizes the importance of a holistic approach that does not simply address direct outcomes such as increased productivity, but also focuses on sustainable human and institutional capacity building. The research highlights that effectively empowering local communities in border governance involves strategic investments in complementary infrastructure, education and participatory processes. Adopting a comprehensive approach, policymakers are able to empower border communities to sustainably process their resources, improve their livelihoods, and contribute positively to sustainable development goals in the border area.
#Nazarpemilu: promoting faith-based populist political communication in the Indonesian presidential election 2024
Authors: Putri Nur A. Dwi , Setiyono Budi , Yuwono Teguh , Erowati Dewi
Published: January 2025

We promise to our God the victory of the presidential candidate we support, that is the essence of #nazarpemilu. Promoting of populist political communication that occurred on the social media platform X during the 2024 Indonesian presidential election campaign. The hashtag is a fascinating trend as it combines elements of religion and the election, and it did not originate from the elites but rather from the supporters.Using a content analysis approach this study aims to explore the role of #Nazarpemilu in shaping faith-based populist political communication during the 2024 Indonesian presidential election campaign on the social media platform X.. We found first, #Nazarpemilu contains various hopes and promises from supporters to their God for the victory of the presidential candidate they support. Second, the involvement of some political actors in the hashtag affiliated with parties with Islamic ideologies. Third, some identified messages contain strategies to persuade other users to vote for the supported presidential candidate and strategies to push the movement into the offline realm. Fourth, this hashtag has an exposure effect on other users. Fifth, this hashtag is also tainted by the activities of pro-Prabowo-Gibran candidate pair buzzer activities countering the hashtag with a reversed narrative. Base on this findings that populist content shared by users that appeals to faith-based in the form of hashtags can play an effective role in spreading populist political communication on the social media platform X and have implications for voters mobilization.
Beyond borders: the dynamic role of Papuan Muslims in governing special autonomy
Authors: Darus Muhammad Rifai , Abdullah Irwan , Qodir Zuly , Jubba Hasse
Published: January 2025

The implementation of special autonomy in Papua Province has raised critical challenges, particularly the marginalization of certain groups based on ethnicity and religion. This study examines the dynamic role of Muslim groups in Papua post-special autonomy implementation, addressing gaps in previous research. Using a qualitative descriptive case study approach, the findings reveal three key points. First, the political engagement of Muslim groups has become more dynamic but remains limited compared to Indigenous Papuans (OAP). Second, special autonomy policies, while intended to empower OAPs, have narrowed the participation space for non-OAP groups, including Muslims. Third, the policies restrict opportunities for Muslim Papuans to hold strategic government positions, as recruitment prioritizes OAP representation. These findings highlight the multidimensional challenges of special autonomy, including social, political, and economic inequalities. The study concludes that, while special autonomy policies offer opportunities for regional development, they also foster tensions and marginalization. To address these issues, it recommends adopting more inclusive governance and balanced policies that accommodate both OAP and non-OAP groups. By doing so, Papua’s development can be more equitable and sustainable, fostering harmony among its diverse communities.
Topics in Computability
Authors:   , Ben-Shahar Sapir
Published: January 2025

This thesis studies two topics in computability. The first is about computable metric and Polish spaces. We compare different notions of effective presentability and construct some spaces that are 'almost computable', in the sense that they do not have a computable presentation but they do have both left-c.e. and right-c.e. presentations. The second part studies c.e. Quasi-degrees (Q-degrees) and c.e. strong Quasi-degrees (sQ-degrees), which have interesting connections to algebra. We show that the c.e. sQ-degrees are not distributive, embed the lattice $N_5$ into them and show that no initial segment forms a lattice. We construct a non-computable c.e. set that has no c.e. simple set Q-below it. We also briefly study the relationship of sQ-degrees to wtt-degrees. Finally we show there is a minimal pair of sQ-degrees within the same Q-degree, and that if a degree is half of a minimal pair in the Q-degrees, it is also half of a minimal pair in the Turing degrees.
The Impact of BCL6 Expression on Cancer Cell Behaviour in a Glioma Model
Authors:   , Myo Min Naychi
Published: January 2025

Glioblastoma (GBM) is the most aggressive and malignant brain tumour, exhibiting some of the lowest survival rates among various cancers, even following interventions such as surgical resection, chemotherapy, and radiation therapy. GBM is characterised by its heterogeneity, invasive phenotype, and resistance to conventional treatment modalities. Key drivers of tumorigenesis play crucial roles in facilitating the ‘hallmarks’ of cancer, including uncontrolled proliferation, evasion of growth-regulatory mechanisms, and, critically, resistance to therapeutic interventions. A comprehensive understanding of these genetic drivers is essential for the development of innovative therapeutic strategies aimed at improving patient outcomes.

BCL6, an established oncogenic driver in diffuse large B-cell lymphomas, also plays a significant role in solid tumours by repressing tumour suppressor genes and promoting survival under stress conditions. Preliminary studies indicate that the inhibition of BCL6 in certain tumour models, including GBM, correlates with reduced tumour growth and increased sensitivity to standard therapies.

In this study, I utilized a newly developed genetically engineered mouse cell line model to investigate the role of BCL6 in GBM. The findings demonstrated that BCL6 overexpression significantly enhanced the proliferation rate of transfected GBM cells without affecting their migratory capacity. Furthermore, the data suggested that BCL6 expression contributes to improved survival rates following chemotherapy exposure. These results substantiate the hypothesis that BCL6 functions as a pivotal driver in the pathophysiology of GBM, positioning it as a promising target for therapeutic intervention. Future investigations will focus on determining whether these BCL6-overexpressing cell lines can initiate tumorigenesis and exploring the potential of BCL6 inhibitors as targeted therapeutic agents.
Desafios da logística reversa de embalagens vazias de agrotóxicos.
Authors: Branco Elisiane , Bucior Lucas , Spada Rafael , Vargas Mores Giana , Dal Moro Leila
Published: January 2025

Ao analisar temas como o descarte de embalagens vazias de defensivos agrícolas é importante observar a necessidade de adotar iniciativas que contemplem a produção e consumo responsáveis. Verifica-se a necessidade de um olhar sustentável constante em relação a esses processos, buscando melhorias e contribuições que venham ao encontro dos Objetivos de Desenvolvimento Sustentável. Para isso, práticas sustentáveis como a logística reversa das embalagens vazias tem um papel importante para contribuir com a Agenda 2030. Este estudo tem como objetivo identificar os principais desafios enfrentados na logística reversa das embalagens de agrotóxicos. O método possui abordagem qualitativa e o objeto de estudos contempla os municípios de Passo Fundo, Muliterno e Getúlio Vargas, do estado do Rio Grande do Sul, Brasil. Os participantes foram líderes que trabalham com a logística reversa dessas embalagens. O instrumento de coleta de dados foi a entrevista semiestruturada. Foi utilizada a técnica de análise de conteúdo para mensurar os resultados. Conclui-se que o principal desafio é manter os envolvidos no processo informados sobre as boas práticas, ademais, o que dificulta o recolhimento das embalagens é principalmente a distância até o ponto de coleta. Como proposta de melhoria são sugeridas intensificação das campanhas de sensibilização e disponibilização de pontos de coleta mais próximos.
Desempenho inovativo influenciado pelo isomorfismo organizacional no Arranjo Produtivo Local (APL) de Confecções de Taquaral de Goiás/GO
Authors: Silva Souza Manuel Fernandes , Pinheiro da Silveira Marco Antonio , Batista de Freitas Vailson
Published: January 2025

No Brasil, os Arranjos Produtivos Locais (APLs) compõem políticas públicas de apoio a clusters empresariais com significativo potencial de desenvolvimento. Este estudo trata dessas aglomerações produtivas e suas relações com a inovação organizacional com objetivo de analisar a ocorrência de isomorfismo organizacional e a busca de conhecimento entre as empresas participantes do Arranjo Produtivo Local (APL) de Confecções de Taquaral de Goiás, Estado de Goiás, observando os efeitos destes elementos no desempenho inovativo do APL. A pesquisa se utilizou de método misto, do tipo sequencial explanatório, e gerou uma representação dos processos de isomorfismo e busca de conhecimento. Na etapa inicial quantitativa do estudo foi aplicado questionário, baseado em escala já existente. Em seguida, foi realizada etapa qualitativa, que visou ampliar os resultados por meio da identificação das fontes de conhecimento exploratory e exploitative. Os fenômenos identificados efetivamente foram o isomorfismo miméticos e a busca de conhecimento exploitative. Em menor intensidade se manifestou a busca de conhecimento exploratory. Ambas as categorias de busca de conhecimento influenciaram o desempenho inovativo do APL. As redes sociais e as outras empresas do grupo destacaram-se como fontes de conhecimento/ imitação e, apesar das empresas mostrarem muita disposição para praticarem o isomorfismo normativo e realizarem a busca de conhecimento exploratory, estes processos ocorrem em menor intensidade. Apesar do foco ter sido um APL de grande relevância para aquela região, por ser um único APL é esta uma limitação deste estudo, embora ele possa ser aplicado ou ampliado em outros arranjos.
Turismo e desenvolvimento local na região Noroeste do Rio Grande do Sul na perspectiva da agenda 2030
Authors: Gai Carolina Casarin , Oliveira Tarcisio Dorn de , Benso Aline , Mueller Airton Adelar
Published: January 2025

Recente pesquisa sobre turismo rural no Brasil aponta para uma crescente demanda por destinos turísticos, com destaque para os estados de Minas Gerais, São Paulo e Rio Grande do Sul. A região Noroeste do Rio Grande do Sul, com sua base econômica agrícola familiar, apresenta potencial para o desenvolvimento do turismo como alternativa econômica sustentável. Este artigo examina como o turismo rural pode contribuir para o desenvolvimento local alinhado com os Objetivos de Desenvolvimento Sustentável. Três dimensões foram analisadas: sustentabilidade ambiental (ODS 15); inclusão social e redução das desigualdades (ODS 10) e desenvolvimento econômico e sustentável (ODS 8). O estudo foi realizado em Boa Vista do Cadeado e Pejuçara, incluindo visitas, envio de formulários eletrônicos às secretarias municipais; levantamento bibliográfico e análise de documentos históricos. Em relação ao potencial turístico, Boa Vista do Cadeado se destaca pelo turismo rural e cultural, localização estratégica e rico patrimônio cultural. Pejuçara, por sua vez, tem demonstrado atuação mais articulada em relação ao potencial turístico, com foco na herança cultural italiana, inserindo-se na rota Recantos da Colônia. É necessário considerar que, embora o turismo traga impactos econômicos, sociais e culturais positivos nas comunidades, deve priorizar as necessidades das comunidades residentes, evitando-se a turistificação que privilegia o lucro em detrimento da preservação cultural e do bem-estar da população.
Carbon Reservoirs in the Biomass and Soil in Livestock Systems with Scattered Trees in Pastures in the Humid Tropics of Mexico
Authors: López-Santiago José Germain , Villanueva-López Gilberto , Casanova-Lugo Fernando , Martínez-Zurimendi Pablo , Jarquín-Sánchez Aarón , Bravo-Oviedo Felipe , Deb Raj Aryal
Published: January 2025

Maintaining trees in grassland areas is an option for enhancing carbon stocks, yet the contribution of dispersed trees in pastures has been little studied in livestock systems in the humid tropics of Mexico, despite being one of the region’s most widely employed silvopastoral modalities. We conducted a study to assess biomass and soil carbon storage in a silvopastoral system, consisting of Brachiaria brizantha grass with native trees dispersed in paddocks (STP) and compared the findings with a pastureland consisting of Brachiaria decumbens grass without trees (WT). Five sampling plots of 1000 m2 size, were randomly selected for each livestock system (STP and WT). At each site, tree biomass was estimated by allometric equations, and herbaceous, litter biomass, and soil organic carbon at four dif ferent depths were quantified by direct sampling method. Of the total biomass in the STP, above-ground biomass contributed 57.3%, below-ground biomass 20%, and ground litter 22.7%. In the case of WT, above-ground biomass represented 40.9% of the total biomass, below-ground biomass 6.4%, and litter 52.7%. The STP system stored a total of 162.3 Mg C ha-1, of which 149.7 Mg C ha-1 in the soil to 70 cm depth and 12.7 Mg C ha-1 in the biomass. WT system stored a total of 116.6 Mg C ha-1, of which 110.7 Mg C ha-1 in the soil and 5.5 Mg C ha-1 in the biomass. It is concluded that the STP livestock system increased 28% of the total carbon storage compared to the WT. However, more studies with greater species diversity and at dif ferent densities are needed to understand better the contribution of trees to carbon accumulation in livestock systems.