bluuebunny/crossref_metadata_2025 huggingface dataset:
Gastroduodenal artery embolization for peptic ulcer hemorrhage refractory to endoscopic intervention: A single-center experience
Authors: Khazi Zain M , Marjara Jasraj , Nance Michael , Ghouri Yezaz , Hammoud Ghassan , Davis Ryan , Bhat Ambarish
Published: June 2022

Objective

To determine the efficacy of gastroduodenal artery embolization (GDAE) for bleeding peptic ulcers that failed endoscopic intervention. To identify incidence and risk factors for failure of GDAE.

Materials and Methods

A retrospective review of patients who underwent GDAE for hemorrhage from peptic ulcer disease refractory to endoscopic intervention were included in the study. Refractory to endoscopic intervention was defined as persistent hemorrhage following at least two separate endoscopic sessions with two different endoscopic techniques (thermal, injection, or mechanical) or one endoscopic session with the use of two different techniques. Demographics, comorbidities, endoscopic and angiographic findings, significant post-embolization pRBC transfusion, and index GDAE failure were collected. Failure of index GDAE was defined as the need for re-intervention (repeat embolization, endoscopy, or surgery) for rebleeding or mortality within 30 days after GDAE. Multivariate analyzes were performed to identify independent predictors for failure of index GDAE.

Results

There were 70 patients that underwent GDAE after endoscopic intervention for bleeding peptic ulcers with a technical success rate of 100%. Failure of index GDAE rate was 23% (n = 16). Multivariate analysis identified ≥2 comorbidities (odds ratio [OR]: 14.2 [1.68-19.2], P = 0.023), days between endoscopy and GDAE (OR: 1.43 [1.11-2.27], P = 0.028), and extravasation during angiography (OR: 6.71 [1.16-47.4], P = 0.039) as independent predictors of index GDAE failure. Endoscopic Forrest classification was not a significant predictor for the failure of index GDAE (P > 0.1).

Conclusion

The study demonstrates safety and efficacy of GDAE for hemorrhage from PUD that is refractory to endoscopic intervention. Days between endoscopy and GDAE, high comorbidity burden, and extravasation during angiography are associated with increased risk for failure of index GDAE.
Multiple non-contiguous anticoagulation-related spontaneous acute spinal intradural extramedullary hemorrhages
Authors: Brooks Christopher Alan , Mahajan Sameer , Choy Wen Jie , Rajah Jayant , Damodaran Omprakash
Published: June 2022

Background:

Spinal intradural extramedullary hemorrhage is a rare and important pathology that may precipitate acute compressive myelopathy. It is most commonly associated with spinal trauma, neoplasia, vasculopathy, and iatrogenesis. In rare circumstances, it occurs spontaneously secondary to anticoagulant and antiplatelet medications without an underlying structural lesion. In these instances, it may be related to vasculopathy and/ or cardiovascular disease risk factors. We highlight the salient clinical and radiological features of this pathology, discuss putative mechanisms of its pathogenesis, and describe surgical considerations related to its management.

Case Description:

This report describes an elderly gentleman who presented with two discrete spinal hemorrhages associated with separate foci of bleeding, in the context of therapeutic anticoagulation, on a background of significant structural and functional cardiovascular disease with risk factors.

Conclusion:

Our report is novel in that there are no other cases, to the best of our knowledge, of multiple non-contiguous anticoagulation-related spontaneous acute spinal intradural extramedullary hemorrhages in the medical literature. This article is written with the purpose of assisting clinicians to recognize and expedite treatment of this rare pathology. Prompt diagnosis followed by urgent decompressive surgery provides the best functional outcomes.
The need for an institution-specific normal pressure hydrocephalus management protocol
Authors: Zhu Ning , Sadasivan Ananthababu Pattavilakom
Published: June 2022

Background:

Despite the publication of international guidelines, the management of normal pressure hydrocephalus (NPH) varies due to clinician preference and varying clinical evidence. An audit was performed to review the current pathways used in clinical practice with the aim of formulating an institution-specific protocol to optimize and standardize care.

Methods:

An internal audit was performed on the management of patients with NPH who presented to the Princess Alexandra Hospital, Brisbane between January 2016 and February 2019.

Results:

Forty-one patients were included in the study. Lumbar puncture (LP) was the main diagnostic test used (63.4%). About 14.6% underwent lumbar drain (LD) insertion instead. About 12.2% did not undergo either LP or LD before definitive treatment. Only 60% of all patients underwent ventriculoperitoneal shunt insertion. Overall, five treatment pathways were noted. LP + VP shunt showed the greatest average improvement in Montreal Cognitive Assessment (MoCA) or Mini-Mental State Examination (MMSE) (+3.8 ± 3.18), followed by LD + VP shunt (+3.25 ± 3.52) and sole treatment with LP (+1.83 ± 1.18). Both pre and post intervention assessment of gait and cognition were only performed in 31% and 48.8% of patients, respectively. Four types of cognitive assessment were used (MOCA 46.4%, MMSE 46.4%, Rowland Universal Dementia Assessment Scale 3.6%, and Addenbrooke’s Cognitive Examination-III 3.6%). MoCA showed greater cognition improvement (2.07) compared to MMSE (1.3) post intervention. There was no consistent objective gait assessment test used.

Conclusion:

The multiple NPH treatment pathways, low rate of pre and post objective symptom assessment, and lack of standardized gait and cognitive assessment tests demonstrate a clear need for an institution-specific NPH management protocol to standardize diagnostic workup, definitive management, and allied health assessment.
Challenges of Checks and Balances in Disaster Management in Indonesia
Authors: Qurrata Ayuni , Satya Arinanto , Fitra Arsil , Maria Farida Indrati
Published: June 2022

This study discusses the importance of checks and balances in disaster management in Indonesia. The context of a disaster is one of the states of emergency conditions that provides discretionary opportunities. However, the concept of checks and balances in disaster management has not yet been constructed in the Disaster Management Law. The inclusion of a checks and balances clause in the disaster management act is very urgent due to three reasons: First, preventing abuse of power from the Government in an emergency, second, involving the central and regional legislative bodies to evaluate the emergency status within a certain period and third, to ensure accountability and transparency in governance. Using a juridical-normative approach complemented by case studies, this study examines the formula of checks and balances in disaster management in Indonesia which is expected to strengthen the rule of law even in an emergency disaster.
Family heads’ preparedness facing landslides: simulation game method and focus group discussion
Authors: Soelistyowati Endang , Yuniarti Siswari , Aditya Ronal Surya
Published: June 2022

Natural disasters can occur suddenly or over an extended period. Earthquakes are notoriously difficult to anticipate in terms of their timing, location and magnitude. Simulated catastrophes in Celaket, Pacet and Mojokerto sparked this investigation of the preparedness efficacy of family leaders via the use of simulation game (SIG) and focus group discussion (FGD). The study designed was quasi-experimental with a pre/post test. The sample size was 150 responders. MANOVA test indicates a p value of 0.05, indicating that Ha is accepted and Ho is rejected. SIG is more successful than FGD in assessing family heads’ preparedness to deal with landslides in Celaket, Pacet and Mojokerto. SIG is also more effective than FGD on family heads’ preparedness in the mitigation, emergency and recovery of landslides. Educational institutions, BPBD, village officials and related parties need to be more intensive in providing disaster training to communities in disaster risk areas.
Quorum quenching a sustainable biofilm mitigation strategy
Authors: Kondakindi Venkateswar Reddy , Nalam Renuka Satya Sree , Pabbati Ranjit , Maddela Naga Raju
Published: June 2022

Globally, over dosage of antibiotics has substantial impact on both human health and environment. Spread of antibiotics usage led to the virulent multidrug resistant pathogen emergence which was mostly contributed by Quorum Sensing (QS), a network phenomenon where bacteria communicate. It plays as an effective strategy ultimately resulting in antibiotic resistance, biofilm formation, bioluminescence, virulence etc. Biofilm formed by bacteria is rigid, selfdefensive, complicated which makes it more infectious in the living host. It suggests a promising strategy to break this strong intracellular communication i.e. quenching quorum sensing or simply Quorum Quenching (QQ). This review projects a brief outline on how bacteria communicate, molecules involved in this phenomenon, what makes a biofilm intact, the QS systems involved and Quorum quenching mechanism.
In vitro antimicrobial and anti-proliferative activity of crude methanolic extract of pigment from Streptomycetes spp. on HT-1080 fibro sarcoma cell line
Authors: Kamble Geetanjali R. , Gireesh Babu K. , Hiremath Shivaprakash V. , Hiremath Murigendra B.
Published: June 2022

The ability to produce secondary metabolites like antibiotics is the characteristic feature of Streptomyces. Besides antibiotics, they are also seen to produce other bioactive compounds of economic importance like pigments which are potentially used in industries with remarkably appealing results. Under this backdrop, extraction of such priceless molecule from microbial source was the aim of this work. Actinomycetes strain isolated from water sample was identified as Streptomycetes with conventional and molecular approach. The metabolite exhibited antibacterial, antioxidant and anticancer activity as evident from the liquid fermentation. The crude ethanolic pigment extract was shown to be antibacterial on gram negative human pathogens. Also it exhibited antioxidant and anticancer activity against two cancer cell lines i.e. HeLa and HT-1080. Pigments from bacteria can be effectively used as natural source of treatment against various human ailments. Our results provide insights into effective role of pigment as potent bioactive metabolites with effective pharmaceutical properties.
Innovative tax administration tools in Russia
Authors: Мorozova N. G. , Korzovatykh Zh. M.
Published: June 2022

The article examines the current system of tax administration in Russia and its innovative tools, actively developed and implemented in the context of the digital technologies’ rapid development and the transformation of the control and supervisory state activities. The purpose of the study is to determine the main directions for improving tax administration in the Russian Federation. The research method was the content analysis of scientific publications on tax administration and control in modern conditions. The paper solves the tasks of the tax authorities’ activities effectiveness evaluating, identifying problems in the application of tax administration tools and ways to solve them. The use of information technologies makes it possible to expand the tax administration possibilities, as the main element in the practical implementation of tax policy, which directly affects the tax control effectiveness. The scientific value of the article lies in determining the directions for further development of tax administration tools aimed at increasing the tax authorities’ efficiency and the service quality for economic entities in digital interaction between the state represented by tax authorities and taxpayers.
Green finance and information technology: contradictions and cooperation
Authors: Zhilkina A. N. , Zhilkin O. N. , Bondarovich E. P.
Published: June 2022

Changing priorities in understanding the drivers of sustainable growth of the global and national economy has led to the emergence and rapid development of green finance with the active support of new information technologies. The article is devoted to the negative and positive impact of information technology on the need for green finance, their development and growing popularity among investors. The latest indicators on harmful emissions into the atmosphere are quite alarming, even modern artificial intelligence technologies, due to their high energy intensity, negatively affect the health of our planet. The study is based on the use of comparison methods, absolute and relative indicators, deduction and induction, value and physical indicators. One of the conclusions of the work is that information technology helps investors make the right decisions on investing in an innovative green economy, green bonds are considered in detail as the main, reliable tool for green finance.
Analysis and main digital bank development directions in Russia
Authors: Mazurina T. Yu. , Neopulo K. L. , Shamanina E. I.
Published: June 2022

Digital technologies are rapidly penetrating the banking sector, making it more flexible, mobile and able to meet the changing needs and preferences of customers under the influence of the digital transformation of the economy. In the current situation, banks have to invest a significant amount of funds in the development of innovations in order to remain in demand in the market. This requires banks not only to change the way they provide services and build communications with customers, but also to qualitatively restructure business processes, methods and approaches to their management. The main purpose of the study is to analyse the features of the formation and development of digital banks in Russia, identify their main types and characterise the main groups of business models. During the study, special attention was paid to the factors contributing to the success of the implementation of the bank’s digital business model. The use of clustering methods, comparative analysis made it possible to distinguish 5 groups of digital banks based on the identity of the operations performed. A comparative analysis of the performance indicators of leading traditional credit institutions and wellknown digital banks has been made. The indicator “return on equity (ROE)” was used as the main indicator for comparative analysis. As the study showed, digital banks were the leaders in terms of high ROE. It article are made about the further trend in the development of digital banks towards the creation of their own platforms and ecosystems, with the observed trend of gradual blurring of the lines between traditional and digital banks.
Human resource management in multinational companies: global and local challenges
Authors: Chernov A. V. , Chernova V. A. , Kogan A. A.
Published: June 2022

This article examines a cross-section of the problems associated with human resources management in multinational companies that HR department managers face in their practice. Since the second half of the 20th century, transnational corporations began to enter foreign markets and face the challenges posed by culturally diverse staff at subsidiaries. Until now, the problems of human resource management in a cross-cultural environment have not lost their relevance. The authors cover the issues of human resource management policies standardization/ adaptation in multinational companies, cultural differences as a necessary condition for human resource management, intercultural communications. This study aimed to help managers of human resource management departments of multinational companies to remove obstacles and see new opportunities for HR management in an intercultural environment.
Competence analysis of artificial intelligence professionals
Authors: Sorokina G. P. , Dolgikh E. A. , Pershina T. A.
Published: June 2022

In the conditions of digitalisation, it is necessary to have the appropriate skills. Therefore, many applicants choose occupations in which information technology (IT) and programming knowledge is predominant. Comprehensive measures for preparing graduates in the context of digitalisation cover the formation of appropriate educational programmes. The aim of the study is to provide recommendations for improving the educational process in the field of artificial intelligence (AI) and machine learning based on comparing various programmes affecting the training of professionals in this field. The research uses the following methods. First, it is a sample survey, due to which 4 Russian universities that provide training in programmes in IT, are selected. Second, this is grouping and typology of basic educational curricula, professional standards and disciplines, due to which appropriate typological groupings, are constructed. That allows specifying requirements for knowledge, skills, and abilities necessary for specialists in the field of AI. A comparative analysis of professional standards taking into account the work of a modern specialist with digital skills has been carried out. The competence approach in the educational process has been defined, and the need for a professional standard for IT specialists has been identified. Based on the results obtained, recommendations have been prepared on the basic disciplines that need to be included in the educational programmes of universities to prepare competitive graduates.
The Beginning/End of Diaspora: A Kernel of Time in a Mystical Mode of Existence
Authors: Jacob Wilson Chacko
Published: June 2022

This article considers the potential payoffs of the diasporic as an analytical category developed from Indian Ocean histories that are related to and distinct from various castings of the global. Historically tracing the Indian Ocean trajectories of a Sufi Muslim family from Hadhramawt in relation to changing terms of sovereignty from the late-eighteenth century through the interwar period, the contours and crises of a normative framework for collective and individual life are recuperated and reexamined. The history of these individuals and the theory of life they presuppose and at times explicitly predicate or oppose afford the historian a view of the diasporic as capable of materializing the simultaneity of this- and other-worldly modes of existence. The article concludes that mystical interruptions of historical time that a critical diasporic lens again makes legible as an enduring global form of life represent rarely appreciated sites of emancipation.
African Pentecostalism in India: Being Born Again in the Diaspora
Authors: Venkatachalam Meera
Published: June 2022

Over the past four decades, since the 1960s, there has been a steady flow of Africans moving to India for short-term activities: education, medical treatment and trade. There is a visible African diaspora in many localities in India. This diaspora is a layered one, consisting of diverse groups of people with different degrees of attachment to India: Africans settled in India with kinship ties, mobile professionals and students, and itinerant traders. Its composition and strength are in a constant flux. This paper will explore how debates and rituals in primarily Pentecostal- Charismatic churches – which have emerged as the focal point of community interaction for contemporary Africans in India – become crucial in shaping, reconfiguring and showcasing the markers of an imagined Africanness. Complex Pan-African diasporic subjectivities are invented, performed, and transmitted (from older residents to new arrivals), in conversation with prejudices and expectations of the host culture. These subjectivities are informed by educational and economic aspirations; visions of moral, personal, and corporate African progress, embedded in memoryscapes of an (Afro) future, articulated through the meta-language of African Pentecostalism.
Ambon Bay, Moluccas, Indonesia
Authors: Slama Martin
Published: June 2022

The island of Ambon, once part of "the Spice Islands", was a nodal point for long-distance trade across the Indian Ocean and subject to European colonial expansion. Today, Ambon City it is the administrative center of the province of the Moluccas, and the island is still home to plurilocal communities that connect this rather peripheral place to other sites of the Indonesian archipelago, the Indian Ocean world and beyond. Taken by Martin Slama in 2015.
YETİŞKİNLER İÇİN DİJİTAL OYUN BAĞIMLILIĞI ÖLÇEĞİ: TÜRKÇE UYARLAMA, GEÇERLİK VE GÜVENİRLİK ÇALIŞMASI
Authors: GÖLLER Levent , PİŞKİN Metin
Published: June 2022

Bu araştırmada Wong ve Hodgins (2013) tarafından geliştirilen Yetişkin Oyun Bağımlılığı Ölçeği’nin Türk kültürüne uyarlanması, geçerlik ve güvenirlik çalışmalarının yapılması amaçlanmıştır. Analizler 509 kişilik bir veri seti üzerinde yürütülmüştür. Ölçeğin geçerlik çalışmaları için birinci ve ikinci düzey doğrulayıcı faktör analizi yapılmış, ayrıca uyum geçerliği bakımından benzer bir ölçekle gösterdiği korelasyon değerleri incelenmiştir. Yapılan birinci düzey doğrulayıcı faktör analizi sonucunda; χ2/sd = 3,01; RMSEA=0,063; CFI=0,97; NFI=0,95; IFI=0,97; RFI=0,95; GFI=0,86; AGFI=0,84; SRMR=0,055; ikinci düzey doğrulayıcı faktör analizi sonucunda ise χ2=1466,23; sd=428; χ2/sd=3,43; RMSEA=0,069; CFI=0,96; IFI=0,96; RFI=0,94; NFI=0,95; SRMR=0,060 gibi uyum indeksleri elde edilmiştir. Uyum geçerliği için Dijital Oyun Bağımlılığı Ölçeği – Kısa Formu ile elde edilen verilerle gösterdiği korelasyon incelenmiştir. Elde edilen korelasyon değerlerinin alt boyutlar için .44 ile .67 arasında olduğu, ölçeğin tümü için ise bu değerin .75 olduğu görülmüştür. Ölçeğin güvenirlik çalışmaları kapsamında Cronbach alfa değerleri hesaplanmış ve alt boyutlar için bu değerin .65 ile .86 arasında değiştiği, ölçeğin geneli için ise .92 olduğu görülmüştür. Ayrıca ölçeğin bileşik güvenirlik değerleri hesaplanmış ve bu değerlerin alt ölçekler için .66 ile .87 arasında; ölçeğin geneli için ise .94 olduğu görülmüştür. Güvenirlik çalışmaları kapsamında ölçekte yer alan maddelerin ayırt edicilik düzeylerini belirlemek ve toplam puanı yordama gücünü saptamak amacıyla düzeltilmiş madde-toplam test korelasyonu (rjx) hesaplanmış ve %27’lik alt-üst gruplar, bağımsız gruplar t testi ile karşılaştırılmıştır. Bu işlem sonucunda % 27’lik alt (n=137) ve üst (n=137) grupların madde puanlarındaki farklara ilişkin t değerlerinin 6,90 ile 21,51 arasında (sd=272; p<.001), düzeltilmiş madde-toplam test korelasyonuna ilişkin değerlerin ise .20 ile .70 arasında değiştiği görülmüştür. Ayrıca ölçeğin güvenirliği eşdeğer yarılar güvenirlik formülü ile incelenmiştir. Spearman-Brown düzeltme formülü ile işlem yapıldığında rtt = .88 sonucuna ulaşılmıştır. Sonuç olarak, yapılan geçerlik ve güvenirlik çalışmaları ile elde edilen verilerin, ölçeğin yetişkinlerin oyun bağımlılık düzeylerini belirlemede yeterli bir ölçme aracı olduğu yönünde değerlendirilmiştir.
Workflow for high-dimensional flow cytometry analysis of T cells from tumor metastases
Authors: Faccani Cristina , Rotta Gianluca , Clemente Francesca , Fedeli Maya , Abbati Danilo , Manfredi Francesco , Potenza Alessia , Anselmo Achille , Pedica Federica , Fiorentini Guido , Villa Chiara , Protti Maria P , Doglioni Claudio , Aldrighetti Luca , Bonini Chiara , Casorati Giulia , Dellabona Paolo , de Lalla Claudia
Published: June 2022

We describe a multi-step high-dimensional (HD) flow cytometry workflow for the deep phenotypic characterization of T cells infiltrating metastatic tumor lesions in the liver, particularly derived from colorectal cancer (CRC-LM). First, we applied a novel flow cytometer setting approach based on single positive cells rather than fluorescent beads, resulting in optimal sensitivity when compared with previously published protocols. Second, we set up a 26-color based antibody panel designed to assess the functional state of both conventional T-cell subsets and unconventional invariant natural killer T, mucosal associated invariant T, and gamma delta T (γδT)-cell populations, which are abundant in the liver. Third, the dissociation of the CRC-LM samples was accurately tuned to preserve both the viability and antigenic integrity of the stained cells. This combined procedure permitted the optimal capturing of the phenotypic complexity of T cells infiltrating CRC-LM. Hence, this study provides a robust tool for high-dimensional flow cytometry analysis of complex T-cell populations, which could be adapted to characterize other relevant pathological tissues.
Umut Şahin: SUMOylation in health and disease
Authors: Şahin Umut
Published: June 2022

Umut Şahin is an Associate Professor in the Department of Molecular Biology and Genetics at Boğaziçi University’s Center for Life Sciences and Technologies. We asked him about his recent paper published in Life Science Alliance (LSA) and his experience in science thus far. He explains how his team built upon their initial in vivo data by further complementing it with in vitro work, and emphasizes the relevance of their study to virology, immunology, as well as to the SUMO community. He shares the long term goals and vision of his laboratory, and explains how past and current connections shape his research interests and fuel his passion for science.
The Interaction of Power and Big Capital in the System of Fur Exports and Provision of the Population of North-Eastern Siberia at the Beginning of the 20th Century
Authors:   Irkutsk State University, Kushnareva M. D.
Published: June 2022

The main purpose of the publication is to analyze the interaction between the authorities and representatives of big business in the organization of trade operations in the north-east of Siberia at the beginning of the 20th century to supply the population of the region with consumer goods and export valuable Siberian raw materials in the interests of the state. Achieving this goal involves the widespread use of previously unpublished and not introduced into scientific circulation sources, most of which are office materials of central and local governments. The article notes that on the eve of the First World War, favorable conditions developed in the sphere of cooperation between the authorities and big business in resolving issues of supplying the population of the region with consumer goods and exporting furs. In the annual meetings under the governor of the Yakutsk region I. I. Kraft was attended by prominent representatives of the Siberian merchants and bankers. Issues of arrangement of land and sea routes of communication were discussed. During the hostilities, the Russian government imposed a number of restrictions on the export of furs. Large firms in North-Eastern Siberia faced the problem of finding new markets for furs and wholesale suppliers of goods. At the meetings, the actions of entrepreneurs were coordinated, commercial agreements were concluded, and supply issues were resolved. The process of interaction between government and business was built quite effectively. Changes in the political system of Russia in 1917 led to the emergence of new forms of interaction between government and big business. One of these forms was government contracts and orders. In 1918–1919 firms completed orders worth 700–900 thousand rubles and solved the problem of food shortages in the Yakutsk region. In 1920, in the context of the nationalization of the property of companies, they completed the final state order for the export of furs and the supply of consumer goods to the region.
VOICE INTERACTION AND OTHER TECHNOLOGIES
Authors: T Dr Malathi Gabriel
Published: June 2022

Inducing a thirst for research among the budding engineering graduates could be the top priority for institutions and teachers who care for the fantastic career of their students. It’s not necessary that the research should be so intense at the beginning of their study. But need for research should be elaborated to these students. Firstly, they should be exposed to the futuristic trends in technology, to the need for the modern society with respect to technology, to the user-friendly operations in modern technology and very importantly they should be taught how to collect validated and authentic information from the available resources.
NATIONAL RESEARCH CONFERENCE ON APPAREL TEXTILE AND FASHION DESIGN
Authors: V Mahalakshmi
Published: June 2022

In this paper, we have discussed about the problems faced by the handloom weavers. Hhandloom industry in India has being exceptionally known for the availability of different designs of fabrics and the manufacture of garments and dresses, which states as the job of millions of weavers utilizing in the handloom fragment in India. The result that reflects for handloom industry to be sustainable in the handloom weavers’ market has to be eenlarged and categorized. In the state economy the handloom sector plays an vital role.
Science Teachers’ Practices During the Pandemic in Portugal
Authors: Baptista Mónica , Costa Estela
Published: June 2022

This paper aims to examine how science teachers adapted their practices to the context of the Covid-19 pandemic and what they learned during the period of confinement.

The participants are fifteen science teachers who currently collaborate on a STEM research project. To collect the data, we used two techniques (individual interviews and teachers’ individual written reflections), which have been analysed using an inductive content analysis approach. The results reveal that adjustments have been made in the design and management of classes. Synchronous classes using digital platforms and other communication infrastructure have been held; experimental distance activities have been implemented, and online courses based on a television programme have been taught. In addition, during the period of confinement, to enable distance learning, teachers developed pedagogical skills using technological skills. Finally, this study highlights the importance of teachers’ role in crisis management, such as during the Covid-19 pandemic.
Limiting Immunogenicity of Diabetic Retinopathy Patient-Derived Induced Pluripotent Stem Cells by Knocking out Human Leukocyte Antigen and Overexpressing Cluster of Differentiation 47
Authors: Khalid Marria , Patel Hawa , Syed Shaza , Lakhi Sabiha
Published: June 2022

Introduction: Diabetic retinopathy (DR), the most common complication of diabetes, is characterized by vision loss due to vascular endothelial cell damage of the retina. Notably, induced pluripotent stem cell (iPSC) therapy has shown promise in the regeneration of the retina after damage. A limitation of using these cells includes the risk of immune-rejection. The knockout of human leukocyte antigen (HLA) proteins prevents a host immune response to non-native cells; however, HLA depletion introduces natural killer (NK) cell-mediated responses. Overexpression of cluster of differentiation 47 (CD47) inhibits the activity of NK cells. This project aims to create a universal DR patient-derived iPSC platform whose immunogenicity is limited through genetic alterations.
Methods: iPSCs will be reprogrammed from DR patient-derived fibroblasts and CRISPR-Cas9 will be used to knock out HLA and overexpress CD47. Alterations will be validated through Sanger sequencing, Western Blot and Immunofluorescence (IF) analysis. DR patient-derived iPSCs will be differentiated into endothelial cells to mimic the DR afflicted endothelial cells. These differentiated cells will then be co-cultured with NK cells and a cytotoxicity assay will be performed. Specifically, a chromium-release assay will be used by loading radioactive chromium into the genetically modified and unmodified endothelial cells and the chromium released by dying cells was monitored.
Results: Compared to the unmodified cells, we expect less NK-mediated cell death for the genetically altered endothelial cells.
Discussion: Effectively limiting the immunogenicity of the donor-derived iPSCs can establish a universal platform for future studies in DR therapy.
Conclusion: The resulting donor-derived iPSCs can be used to test drug therapies for DR or new methods to repair blood vessel damage, among a multitude of new research.
Struktur Modal, Ukuran Perusahaan, Pertumbuhan Perusahaan dan Tax Avoidance Terhadap Nilai Perusahaan
Authors: Sa'diyah Chalimatus , Hariyono Anwar
Published: June 2022

This study aims to examine the effect of capital structure, firm size, firm growth and tax avoidance on firm value. The novelty in this study is found in the  population used by manufacturing companies listed on Indonesia Stock Exchange (IDX) during the period 2017-2019. Sample determination was done by purposive sampling method, 168 samples selected on this study. This study uses quantitative methods with secondary data sources in the form of complete company annual reports. Methods of data analysis using multiple linear regression analysis. The results showed that partially the firm size and firm growth have a effect on firm value. While the capital structure and tax avoidance have no effect on firm value. Then, simultaneously the capital structure and firm size have a (significant) effect on firm value. Firm growth and tax avoidance have a effect on firm value.
Analisa Pengaruh Kompetensi, Independensi, Serta Fee Audit Terhadap Kualitas Audit: Studi KAP Semarang
Authors: Putriana Nada Syifaa Bella , Hanum Ayu Noviani , Kristiana Ida
Published: June 2022

This research aims to prove empirically the effect of competence, independence, and audit fees on audit quality with the object of research at the Semarang public accounting firm. the method of research using quantitative and primary data which is form of a questionnaire. The sampling of research using the convenience sampling technique, which is a technique refers to respondents who are willing to fill out a questionnaire regardless of gender, age, and length of work experience. The results of research to indicate competence and independence that have a indicatory positive impact on audit quality. Meanwhile, the Audit Fee has a positive and it is not significant with that.
Syntheses of cobalt and nickel coordination polymers composed of 1,3-adamantanedicarboxylate and bis(4-(1H-imidazol-1-yl)phenyl)methanone ligands
Authors: Wang G.-F. , Sun S.-W.
Published: June 2022

Two coordination polymers, {[Co2(L1)2(adc)2]·5H2O}n (1) and {[Ni(L1)2(Hadc)2]}n (2) (L1 = bis(4-(1H-imidazol-1-yl)phenyl)methanone, H2adc = adamantane-1,3-dicarboxylic acid), have been synthesized and structurally characterized. In 1, Co1 is five-coordinated by three oxygen atoms of two adc2- and two nitrogen atoms from two L1 ligands. The neighboring [Co(adc)]2 dimers are linked through four L1 ligands to form a 1D ladder structure. In 2, Ni1 is six-coordinated by two oxygen atoms from two Hadc- ligands, four nitrogen atoms from four distinct L1 ligands to give a slight distorted octahedral geometry. The [Ni(Hadc)2] units are bridged by L1 ligands to form 1D looped chains.
Expression of Bax Protein as A Prognosis Factor of Radiotherapy Response to Decreased Tumor Size in Stage IIB-IIIB Cervical Cancer
Authors: Fitriawan Ahmad , Udiyanto Hermawan , Respati Supriyadi Hari , Ratnasari Affi Angelia , Prabowo Wisnu
Published: June 2022

Background: Cervical cancer plays a role as the leading cause of cancer death for women in developing countries. Radiation therapy kills cancer cells through double strand breaks and the apoptotic process. Bax protein is one of the regulators of apoptosis. This study analyzed the role of Bax expression as a prognostic factor in radiation therapy response in reducing tumor size in patients with advanced cervical cancer (IIB-IIIB).
Subjects and Method: This research is a retrospective cohort observational analytic study from January 2021 to April 2021 in the Department of Obstetrics and Gynecology in collaboration with the Department of Anatomical Pathology, Dr. Moewardi Hospital, Surakarta, Indonesia. This study involved 30 cervical cancer stage IIB-IIIB patients. The level of Bax expression was determined by immunohistochemical examination. ROC curve analysis was used to find cut-off points and evaluate the sensitivity and specificity of Bax in the prognosis of radiotherapy in patients with advanced cervical cancer (IIB-IIIB). Chi square test was used to determine the relationship between Bax expression and changes in tumor size in cervical cancer patients.
Results: The ROC curve analysis showed that the AUC Bax score in prognosis of radiation therapy was 0.575 (CI 95%= 0.32 to 0.83) and the cutoff point was 62.5%. Based on the analysis of the ROC curve, the Bax expression of 62.5% shows a sensitivity of 56.5% and a specificity of 71.4%. Analysis of the relationship between Bax protein expression on changes in tumor size using the Chi Square test showed a P value of 0.390 (p> 0.05).
Conclusion: The expression of Bax protein cannot play a role as a prognostic factor in the response of radiation therapy to the reduction in tumor size in stage IIB-IIIB uterine cervical cancer.
Outbreak of Salmonella Newport linked to imported frozen cooked crayfish in dill brine, Sweden, July to November 2019
Authors: Jansson Mörk Marie , Karamehmedovic Nadja , Hansen Anette , Nederby Öhd Joanna , Lindblad Mats , Östlund Emma , Rehn Moa , Jernberg Cecilia
Published: June 2022

In autumn 2019, the Public Health Agency of Sweden identified a cluster of Salmonella Newport cases by whole genome sequencing (WGS). Cases’ distribution in place and time indicated a nation-wide ongoing outbreak. An investigation was initiated to identify the source and prevent further cases. We conducted a case–case study based on notified salmonellosis cases and a Salmonella trawling questionnaire, comparing 20 outbreak cases and 139 control cases. Food exposures were compared by adjusted odds ratios (aOR) with 95% confidence interval (CI) using logistic regression. Implicated foods were sampled. Outbreak cases were more likely to have consumed crayfish (aOR = 26; 95% CI: 6.3–105). One specific brand of imported frozen, pre-cooked whole crayfish in dill brine was identified as the source. Salmonella Newport was later detected in different batches from retail and in one sample from border control. Isolates from food samples clustered with the human outbreak strain by WGS. Although the retailer made a complete recall, two more cases were identified long afterwards. This investigation demonstrated the successful use of a case–case study and targeted microbiological testing to identify the source. The immediate action taken by the retailer was important to confirm the source and stop the outbreak.
Ongoing monkeypox virus outbreak, Portugal, 29 April to 23 May 2022
Authors: Perez Duque Mariana , Ribeiro Sofia , Martins João Vieira , Casaca Pedro , Leite Pedro Pinto , Tavares Margarida , Mansinho Kamal , Duque Luís Miguel , Fernandes Cândida , Cordeiro Rita , Borrego Maria José , Pelerito Ana , de Carvalho Isabel Lopes , Núncio Sofia , Manageiro Vera , Minetti Corrado , Machado Jorge , Haussig Joana M , Croci Roberto , Spiteri Gianfranco , Casal Ana Sofia , Mendes Diana , Souto Tiago , Pocinho Sara , Fernandes Teresa , Firme Ana , Vasconcelos Paula , Freitas Graça
Published: June 2022

Up to 27 May 2022, Portugal has detected 96 confirmed cases of monkeypox. We describe 27 confirmed cases (median age: 33 years (range: 22–51); all males), with an earliest symptom onset date of 29 April. Almost all cases (n = 25) live in the Lisbon and Tagus Valley health region. Most cases were neither part of identified transmission chains, nor linked to travel or had contact with symptomatic persons or with animals, suggesting the possible previously undetected spread of monkeypox.
Purchase intention predicting factors in Indonesian fashion brands
Authors: Clarence Clarence , Keni Keni
Published: June 2022

Consumer buying intentions can be predicted by digital marketing, customer engagement, and customer perceived value. This study aims to empirically test digital marketing, customer engagement, and customer perceived value, as well as brand preference in mediating customer perceived value on purchase intention. In this study, the sample collected was 217 respondents. Data were collected and distributed by online questionnaires using Google form and data analysis of this research uses PLS-SEM method. The result shown by this study shows digital marketing and customer engagement can predict purchase intention. Furthermore, customer perceived value cannot predict purchase intention directly, but customer perceived value can predict consumer purchase intention through brand preference. The results of this study are expected to be able to help companies to make the right marketing strategies by taking into account the factors that can predict consumer buying intentions.
Optimalisasi prosedur pelayanan publik dengan perancangan e-government berbentuk website pada masa pandemi Covid-19
Authors: Pertiwi Gina Sukma , Azis Anton Mulyono
Published: June 2022

Dinas Pemberdayaan Masyarakat dan Desa (DPMD) Jawa Barat merupakan lembaga pemerintah yang melandasi kegiatan yang berkaitan dengan setiap di Jawa Barat. Penerapan prosedur pelayanan publik versi lama di masa pandemi COVID-19 mengakibatkan prosedur pelayanan publik kurang optimal dan tidak efektif. Tujuan penelitian ini adalah untuk mengetahui prosedur pelayanan publik, mengetahui faktor-faktor penyebab belum optimalnya prosedur pelayanan publik manual, dan mengetahui perkembangan prosedur pelayanan bantuan keuangan desa dengan desain website e-government. Metode yang digunakan adalah metode eksploratif dengan pendekatan deskriptif. Teknik pengumpulan data menggunakan wawancara, observasi, dokumentasi dan studi kepustakaan. Pengolahan data menggunakan fishbone diagram untuk mengidentifikasi penyebab belum optimalnya prosedur pelayanan publik manual. Hasil dari penelitian ini adalah belum optimalnya penerapan prosedur pelayanan publik manual pada masa wabah Covid-19 yang disebabkan oleh faktor manusia, material, prosedur, teknologi dan lingkungan. Oleh karena itu perlu dikembangkan prosedur pelayanan publik manual menjadi berbasis online atau e-government sebagai upaya yang penulis berikan untuk dapat digunakan dalam penyelenggaraan pelayanan publik.
Teknologi Finansial, Literasi Keuangan, dan Keputusan Investasi Produk Reksa Dana di Indonesia
Authors: Kusumahadi Teresia Angelia , Utami Novia
Published: June 2022

Penelitian dilakukan untuk melihat karakteristik dari pengguna teknologi finansial reksa dana di Indonesia, hubungan antara penggunaan teknologi finansial investasi dan literasi keuangan terhadap keputusan investasi, serta perbedaan literasi keuangan antara investor yang menggunakan teknologi finansial dan investor yang tidak menggunakannya. Dengan menggunakan sampel sebanyak 219 responden yang pernah atau sedang memiliki produk investasi reksa dana, kami menemukan bahwa sebagian besar responden pernah menggunakan teknologi finansial, dengan Bibit dan Bareksa sebagai platform yang paling sering digunakan.

Dengan menggunakan metode OLS, ditemukan bahwa keputusan investasi dipengaruhi secara positif dan signifikan oleh variabel literasi keuangan. Sebaliknya, penggunaan teknologi finansial tidak memiliki pengaruh terhadap keputusan investasi yang dilakukan. Selain itu, investor yang menggunakan layanan teknologi finansial memiliki skor literasi keuangan yang lebih rendah dibandingkan dengan investor yang tidak menggunakan teknologi finansial. Temuan ini menekankan kepada kita perlunya sosialiasi yang lebih merata mengenai teknologi finansial dan literasi keuangan, yang pada akhirnya diharapkan berdampak pada meningkatnya inklusi keuangan.
Faktor pengaruh purchase intention pada fastfood Burger King: peran dari brand equity
Authors: Goh Angelina , Candy Candy
Published: June 2022

Penelitian tentang faktor-faktor yang memengaruhi niat beli pada Burger King di kota Batam dilaksanakan dengan tujuan menguji signifikansi antara kesadaran merek, loyalitas merek, dan kualitas yang dirasakan terhadap niat beli yang dimediasi dengan ekuitas merek. Studi ini dilaksanakan dengan menggunakan metode statistik deskriptif dan verifikatif yang memperoleh 234 orang responden. Sampel penelitian diperoleh menggunakan cara purposive sampling dan pengukuran Likert scale. Responden dikumpulkan dengan cara pengisian Google Form oleh masyarakat yang melakukan pembelian terhadap produk cepat saji Burger King di Kota Batam. Data dari studi kemudian diolah menggunakan Partial Least Square (PLS) dan perangkat lunak SmartPLS 3.0. Hasil penelitian menyatakan terdapat pengaruh signifikan positif antara kesadaran merek, loyalitas merek, dan kualitas yang dirasakan terhadap ekuitas merek. Pengaruh signifikan positif juga terdapat pada pengaruh variabel kesadaran merek, loyalitas merek, dan ekuitas merek terhadap niat beli. Kemudian, variabel ekuitas merek memiliki pengaruh signifikan dalam memediasi variabel kesadaran merek, loyalitas merek, dan persepsi kualitas merek terhadap niat beli. Akan tetapi, tidak terdapat pengaruh signifikan antara kualitas yang dirasakan terhadap niat beli. Hal ini dapat mengindikasikan bahwa persepsi kualitas yang diterima konsumen mampu berkontribusi terhadap penilaian kepada ekuitas merek, akan tetapi tidak selalu berujung dengan memiliki niat beli.
Diagnostic and Survey Study of Toxoplasma gondii in the Soil in Mosul City-Iraq
Authors: Al-Hassan Nawras T.
Published: June 2022

The present study deals to diagnose Toxoplasma gondii cysts in the soil of Mosul city, with a total of 50 samples were collected from each side of the city and three replications using flotation methods and microscopic methods. The study aims to detect contamination Toxoplasmosis oocysts, in the soil with making a comparison between the right and left side of the city and determine the effect of environmental factors such as humidity on the presence of the parasite through making a comparison between wet and dry soil samples. Molecular methods confirmed the presence of infection where the microscopic examination explained the presence of 20 positive samples out of 100 samples for both sides of the city where 11 positive cases found in the right side and 9 positive samples in the left side. The difference was clear between the wet samples with a rate of (14/48) positive samples, while the number of positive dry samples was (6/52) that confirmed infected 8 of the positive samples were subjected to a molecular examination using the polymerase chain reaction (PCR). Furthermore, the results showed the presence of 3 positive samples for B1 gene of the Toxoplasma parasite. The study proved the presence of soil contamination with parasite oocysts, which gives a measure of the high incidence of toxoplasmosis in Mosul city and the possibility of transmitting the infection to the rest of the intermediate hosts including humans.
Students struggle towards curriculum change in Economics Education
Authors: Delgado Sandra
Published: June 2022

The economy is the central narrative in which our current society constantly justifies any important decision, from education, job security to public health, even in the midst to the COVID-19 pandemic. Crises and economic instabilities seem to have become an unending circumstance of capitalists’ societies, and it seems that there is not a way out within the possibilities of mainstream economics. In this paper, I narrate how the 2008 economics crisis was a political opportunity for economics students around the world to organized themselves to challenge economics education and how students propose economics departments to teach economics if we want to change our economy.