bluuebunny/crossref_metadata_2025 huggingface dataset:
Antimicrobial and Anti-Colorectal Cancer Activities of Some Volatile Oils
Authors: Intaraphairot Torsak , Khaing Ei Mon
Published: March 2022

Volatile oils are natural compounds that can be adopted in many drug and cosmetic formulations. Many volatile oils can be extracted from natural plants and they have their own special biological activities. Nine volatile oils including pine oil (P), guava leaf oil (G), lime peel oil (L), cinnamon bark oil (C), sage oil (S), tea tree oil (T) rosemary oil (R), clove oil (CL) and jasmine sambac oil (J) were in vitro tested for anti-microbial activities against various microbes and cytotoxicity properties agianst HCT116 and HT29 cell lines. From our result, for antimicrobial activities, the most effective oil against Gram positive such as Staphylococcus aureus are T, R and L. Only P showed the great inhibition on Gram negative bacteria such as Escherichia coli. C, P, L, T and R also exhibited different inhibitory effects on the pathogenic yeasts depending on the candida species. For the antitumoral activity on colorectal cancer cell lines, C showed the most cytotoxicity on both HCT116 and HT29 cells with IC50 value of 7.7 and 74.0 μg/ml, respectively. The second most cytotoxic was guava oil with the IC50 of 101.2 and 97.91 μg/ml on HCT116 and HT29, respectively. These investigated data may be useful as information for oil selection and development of pharmaceutical dosage forms using these natural volatile oils as the ingredients.
Dried fish production and trade in Negombo, Sri Lanka
Authors: Neranjala T. P. U. , Eranga W. G. D. , Dissanayake D. C. T.
Published: March 2022

A well-established year-around dried fish production process is practiced at Negombo, the west coast of Sri Lanka, and this study evaluates the present status of this industry using the data collected from February to December 2017. There are forty-two dried fish processing centres at Negombo sea street area, providing livelihood opportunities for ~320 employees. Eighteen fish species belonging to 9 families are used in dried fish production and species belonging to the family Carangidae made the highest percentage contribution (21.6%), followed by the Clupeidae (21.4%), and Scombridae (21.4%). The results of the Quality Index (QI)Method revealed that both high-quality and very low-quality fish are used in dried fish production, and the overall QI of Katsuwonus pelamis, Euthynnus affinis, Decapterus macarellus, and Elagatis bipinnulata ranged from 15–16. Effects of drying on proximate composition were assessed, and significantly higher crude protein, content was recorded in dried fish than in fresh fish (p<0.05, t-test). Drying has also resulted in a significant increase in crude fat content in all these species except for Canthidermis maculatus (p<0.05; t test). De-heading and gutting, washing, salting, rewashing, drying, and packing were the major steps in the dried fish production process. Although the total coliform was reported in water samples used in the dried fish processing centres, it was not encountered in any of the dried fish samples. The dried fish value chain mainly consisted of fishermen, buyers, processors, sellers, and consumers, and upgrading of products, processes, and functions along the value chain was suggested to produce better quality dried fish and increase the profit margins of value chain actors.
The impact of uncorrected refractive error and visual impairment on the quality of life amongst school-going children in Sekhukhune district (Limpopo), South Africa
Authors: Magakwe Tshubelela S.S. , Hansraj Rekha , Xulu-Kasaba Zamandoda N.Q.
Published: March 2022

Background: Uncorrected refractive error (URE) and subsequent visual impairment (VI) is expected to have an impact on the quality of life (QoL) amongst schoolchildren.Aim: This study aimed to determine the impact of URE and VI on the QoL amongst school-going children aged 14–18 years.Settings: The study was performed at Sekhukhune district in the Limpopo province, South Africa.Methods: The tool used to assess the QoL was the National Eye Institute Quality of Life Questionnaire (NEI-VFQ-25). A modified refractive error study in children (RESC) protocol was employed to determine the value of URE and VI. The tests performed included Logarithm of the Minimum Angle of Resolution (LogMAR) visual acuity, cycloplegic autorefraction, binocular motor function tests, media and fundus examination.Results: A total of 154 learners, aged 14–18 years completed the NEI-VFQ-25, which was offered in an interview format. A total of 56 learners (36.3%, 95% confidence interval [CI]: 14.9–27.9]) had URE and VI. Children with URE and VI scored low on the NEI-VFQ-25 as compared with those without URE and VI.Conclusion: Uncorrected refractive error has an impact on the QoL of learners in the greater Sekhukhune district. This calls for policymakers and other relevant stakeholders in basic education to prioritise programmes that seek to address the visual health of scholars in rural schools.
Demographic and clinical profiles of residents in long-term care facilities in South Africa: A cross-sectional survey
Authors: Kalideen Letasha , Van Wyk Jacqueline M. , Govender Pragashnie
Published: March 2022

Background: The demand for long-term care facilities (LTCFs) amongst older people in South Africa (SA) is growing and there is insufficient information on the profile and healthcare needs of this population.Aim: This study was conducted to describe the demographic and clinical characteristics of residents in LTFCs in SA.Setting: Three LTCFs in eThekwini district.Methods: A cross-sectional design was used to collect data from a purposive sample of 102 (N = 204) residents. A structured questionnaire was used to collect demographic and clinical data. The data were entered into Microsoft Excel and analysed descriptively and inferentially using R version 3.5.1 software.Results: The majority of the residents (59.8%) were between 65 and 80 years (78.9 ± 8.1 years) and 74.5% were women. The residents were white people (91.1%), SA born (82.4%) and widowed (54.9%). English was the primary language (91.1%), with the majority being christian (52.0%). Some residents had a university education, were previously employed and are financially independent. Ninety-three percent had clinical conditions, each suffering from at least three clinical conditions. Hypertension (63.7%), high cholesterol (53.9%), arthritis (38.2%), depression (37.3%) were the most prevalent clinical conditions recorded amongst the residents. Most residents were assessed to be intermediately frail, at risk of malnutrition and had mild depression as based on the respective mean frailty-, nutrition-, and geriatric depression scores.Conc lusion: Residents in LTCFs in the eThekwini district are more likely to be white people; women, christian, widowed, intermediately frail and at risk of malnutrition.
What literary studies can offer sexuality education: Pre-service teachers’ responses to an animated film
Authors: Carolin Andy
Published: March 2022

Background: Given the high levels of homophobia that exist in South Africa, including in its schools and universities, it is imperative that university lecturers develop integrated and transdisciplinary curriculums to educate pre-service teachers about sexuality and to empower them to incorporate lesbian, gay, bisexual, transgender and intersex (LGBTI)-inclusive resources into their own classrooms.Aim: This study aimed to contribute to the scholarship of teaching and learning by reflecting on how English literary studies can contribute to sexuality education.Setting: The context for this study is a specific undergraduate English module that forms part of the foundation phase and intermediate phase teacher education curriculums at the University of Johannesburg.Methods: This study is a self-reflective analysis of how the methodology of close reading, which is central to English literary studies, can be used to support sexuality education.Results: Despite the prevalence of homophobia in South African society, when undergraduate students in this English module (n = 356) were asked to write an essay about the representation of same-sex sexuality in a short animated film, none of them made homophobic comments.Conclusion: Paying particular attention to the analytical methodology of close reading, the author argues that a narrow focus on the storytelling techniques used within a narrative text – in a way that deliberately excludes students’ personal opinions about same-sex sexualities – offers a powerful way of facilitating a deeper understanding of the mechanisms of homophobia and heteronormativity.
Pooled diagnostic parameters of artificial intelligence in EUS image analysis of the pancreas
Authors: Mohan Babu P. , Facciorusso Antonio , Khan Shahab R. , Madhu Deepak , Kassab Lena L. , Ponnada Suresh , Chandan Saurabh , Crino Stefano F. , Kochhar Gursimran S. , Adler Douglas G. , Wallace Michael B.
Published: March 2022

EUS is an important diagnostic tool in pancreatic lesions. Performance of single-center and/or single study artificial intelligence (AI) in the analysis of EUS-images of pancreatic lesions has been reported. The aim of this study was to quantitatively study the pooled rates of diagnostic performance of AI in EUS image analysis of pancreas using rigorous systematic review and meta-analysis methodology. Multiple databases were searched (from inception to December 2020) and studies that reported on the performance of AI in EUS analysis of pancreatic adenocarcinoma were selected. The random-effects model was used to calculate the pooled rates. In cases where multiple 2 × 2 contingency tables were provided for different thresholds, we assumed the data tables as independent from each other. Heterogeneity was assessed by I
2% and 95% prediction intervals. Eleven studies were analyzed. The pooled overall accuracy, sensitivity, specificity, positive predictive value, and negative predictive value were 86% (95% confidence interval [82.8–88.6]), 90.4% (88.1–92.3), 84% (79.3–87.8), 90.2% (87.4–92.3) and 89.8% (86–92.7), respectively. On subgroup analysis, the corresponding pooled parameters in studies that used neural networks were 85.5% (80–89.8), 91.8% (87.8–94.6), 84.6% (73–91.7), 87.4% (82–91.3), and 91.4% (83.7–95.6)], respectively. Based on our meta-analysis, AI seems to perform well in the EUS-image analysis of pancreatic lesions.
Universal Screening for Lynch Syndrome Compared with Pedigree-Based Screening: 10-Year Experience in a Tertiary Hospital
Authors: Kim Min Hyun , Kim Duck-Woo , Lee Hye Seung , Bang Su Kyung , Seo Soo Hyun , Park Kyung Un , Oh Heung-Kwon , Kang Sung-Bum
Published: March 2022

Purpose Universal screening for Lynch syndrome (LS) refers to routine tumor testing for microsatellite instability (MSI) among all patients with colorectal cancer (CRC). Despite its widespread adoption, real-world data on the yield is lacking in Korean population. We studied the yield of adopting universal screening for LS in comparison with pedigree-based screening in a tertiary center.Materials and Methods CRC patients from 2007-2018 were reviewed. Family histories were obtained and were evaluated for hereditary nonpolyposis colorectal cancer (HNPCC) using Amsterdam II criteria. Tumor testing for MSI began in 2007 and genetic testing was offered using all available clinicopathologic data. Yield of genetic testing for LS was compared for each approach and step.Results Of the 5,520 patients, tumor testing was performed in 4,701 patients (85.2%) and family histories were obtained from 4,241 patients (76.8%). Hereditary CRC (LS or HNPCC) was present in 69 patients (1.3%). MSI-high was present in 6.9%, and 25 patients had confirmed LS. Genetic testing was performed in 41.2% (47/114) of MSI-high patients, out of which 40.4% (19/47) were diagnosed with LS. There were six additional LS patients found outside of tumor testing. For pedigree-based screening, Amsterdam II criteria diagnosed 55 patients with HNPCC. Fifteen of these patients underwent genetic testing, and 11 (73.3%) were diagnosed with LS. Two patients without prior family history were diagnosed with LS and relied solely on tumor testing results.Conclusion Despite widespread adoption of routine tumor testing for MSI, this is not a fail-safe approach to screen all LS patients. Obtaining a thorough family history in combination with universal screening provides a more comprehensive ‘universal’ screening method for LS.
Prediction of Cancer Incidence and Mortality in Korea, 2022
Authors: Jung Kyu-Won , Won Young-Joo , Kang Mee Joo , Kong Hyun-Joo , Im Jeong-Soo , Seo Hong Gwan
Published: March 2022

PurposeThis study aimed to report the projected cancer incidence and mortality for the year 2022 to estimate Korea’s current cancer burden. Materials and MethodsCancer incidence data from 1999 to 2019 were obtained from the Korea National Cancer Incidence Database, and cancer mortality data from 1993 to 2020 were acquired from Statistics Korea. Cancer incidence and mortality were projected by fitting a linear regression model to observed age-specific cancer rates against their respective years and then by multiplying the projected age-specific rates by the anticipated age-specific population for 2022. A joinpoint regression model was used to determine the year in which the linear trend changed significantly; we only used the data of the latest trend. ResultsIn total, 274,488 new cancer cases and 81,277 cancer deaths are expected to occur in Korea in 2022. The most common cancer site is expected to be the thyroid, followed by the lung, colon and rectum, breast, and stomach. These five cancers are expected to represent half of the overall burden of cancer in Korea. The most common type of cancer leading to death is expected to be lung cancer, followed by liver, colorectal, pancreatic, and gallbladder cancers. ConclusionThe incidence rates for all types of cancer in Korea are estimated to gradually decrease. These up-to-date estimates of the cancer burden in Korea could be an important resource for planning and evaluating cancer-control programs.
Constellations of kinship in the medieval nobility of Île-de-France (1000-1440)
Authors: Nabias Laurent
Published: March 2022

Jeu de données : voir lien ci-dessous

This article provides a detailed description of the network of alliances and the matrimonial constellations established from 1000 to 1440 between noble “topolineages” of the upper, middle and low nobility in the Île-de-France (Paris region), with the aim of understanding their marital strategies. For these topolineages, the aim was to ensure the reproduction of aristocratic domination in a context where new actors emerged, including recently ennobled individuals who were aggregated to the existing nobility. Using the Puck software, the author carries out a systematic exploration of alliances and realliances formed through affinity and inbreeding in order to identify the role played by kinship in solidarities. Datasets stored on the Kinsource platform are used to build dated graphs of these networks, highlighting alliances and consanguineous marriages. The development of network patterns makes it possible to identify expansions of matrimonial components, as well as the interruption of their expansion around 1290. Computer analysis shows that aristocrats looked for their spouses within authorized boundaries, and did not hesitate to reproduce past unions between the same lineages as long as the generational gap between the common ancestors and the spouses complied with canonical laws.

L’article décrit de manière détaillée le réseau d’alliance et les constellations matrimoniales entre 1000 et 1440 de quelques topolignées nobiliaires franciliennes de la haute, moyenne et basse noblesse, pour aborder les stratégies matrimoniales établies. L’enjeu est d’assurer la reproduction de la domination aristocratique, où apparaissent différents acteurs dont de nouveaux individus anoblis qui s’agrègent aux parentèles nobiliaires existantes. Une méthode d’exploration systématique des alliances et renchaînements d’alliances dans l’affinité et dans la consanguinité est présentée pour identifier les parentés engagées dans ces solidarités à l’aide du logiciel Puck. L’évolution des figures de réseaux permet d’identifier les expansions de composantes matrimoniales. Le jeu de données est disponible en libre accès sur la plateforme Kinsource.
Journey in cluster: What about its relational promise ?
Authors: Vallier Estelle
Published: March 2022

This article focuses on inter­-organizational and interpersonal networks within a biocluster (a geographical pool of biotechnology companies, laboratories and universities). Diverse forms of interactions and interpenetration can be observed across the three spheres of science, industry and education. Using network analysis and the traditional methods of sociology (observations, interviews and surveys), this article reveals that while there are limited formal relations between organizations, phenomena of mutual acquaintance can be observed on an inter­individual level. At employee level, these acquaintances manifest themselves through a shared sense of belonging to the "small world of genomics", and through the sharing of experience in case of problems. Within teams, there are collegial and sometimes even friendly relations, but they rarely turn into professional interaction. In this context, individuals may activate their interpersonal networks for the purposes of occupational mobility, giving rise to an internal labor market. However, this market is disconnected from local students, although the university works to adapt its curriculum to the needs of local companies and laboratories.

Cet article s'intéresse au réseau inter­-organisationnel et interindividuel d'un biocluster (groupement géographique d'entreprises, de laboratoires et de formations dans le domaine des biotechnologies). Il s'attache à montrer les différentes formes d'interactions ou d'incommunicabilités qui traversent les trois sphères suivantes : science, industrie et formation. Empruntant les techniques d'analyse de réseau et les méthodes en sciences sociales (observations, entretiens et questionnaires), il montre des relations formelles limitées entre les organisations mais rend compte, au niveau interindividuel, de plusieurs phénomènes d'interconnaissance. Au niveau des dirigeant.e.s, cette interconnaissance se manifeste par une appartenance au « petit monde de la génomique » et par du partage d'expérience en cas de problèmes. Au niveau des équipes, cela se traduit davantage par des relations dites conviviales, voire jusqu'à l'émergence de liens d'amitié, mais qui se convertissent dans très peu de cas en échanges professionnels. En effet, les réseaux interpersonnels sont plutôt mobilisés afin de circuler professionnellement dans les différentes organisations participant à l'émergence d'un marché du travail interne au cluster. Néanmoins, ce marché du travail interne n'est pas appareillé aux étudiant.e.s de l'université locale alors que l'offre de formation de proximité est paradoxalement de plus en plus en adéquation avec les besoins des entreprises et laboratoires.
Calidad y estado fisiológico del café al momento de la cosecha y su efecto en el rendimiento en Puerto Rico
Authors: Carlos A. Flores-Ortega  , Raúl Macchiavelli  , Osvaldo Bosque  , Raúl Toledo
Published: March 2022

Se estudió el efecto de localización (medianía y altura) y del momento en que se realizó la cosecha del café (al principio, pico y final) sobre el estado fisiológico de la fruta cosechada y llevada al beneficiado comercial como fruta madura durante los años 2009 y 2010. Se analizó el efecto de los estados fisiológicos del fruto y el daño ocasionado por la broca del café (Hypothenemus hampei Ferrari 1867) con relación a la cantidad de café que flota cuando se somete a la prueba de flotación y los efectos de estas interacciones con relación al rendimiento y tamaño del fruto de café después de pilado. Los resultados indican que existe una alta variabilidad entre una cosecha y otra en términos de la proporción de café maduro, pintado, verde y sobre maduro que constituye la clasificación de café maduro comprado por los beneficiadores compradores. La proporción de café maduro varió entre un 50% y un 70% de un año a otro, proporciones muy bajas para obtener buen rendimiento y calidad del café. La presencia de café verde en los niveles de un 4.34% y un 13.73% implica menor rendimiento y un deterioro de la calidad del café, lo cual requerirá esfuerzo y gasto adicional para la separación de este grano que se pagó como grano maduro. El rendimiento del café una vez despulpado y lavado fluctuó entre un 40% y un 43%. Se observó también de un 2% a un 3.5% de café que flotaba por condiciones fisiológicas no relacionadas al daño por broca. Hasta un 3% del café caracolillo, después de despulpado, flota y se puede estar perdiendo durante el proceso de lavado. Se observó que los promedios de granos seleccionados en tamiz #14 (más pequeño) y #17 fueron mayores que las cantidades seleccionadas en tamiz #19 (más grande). Los resultados indican que el porcentaje de café pergamino al 12% de humedad fluctúa entre un 20% y un 21% del peso fresco. Estos resultados demuestran que la calidad y el rendimiento del café se definen al momento de la cosecha. Para Â¡ncursionar en mercados de café de exportación, se requieren altas proporciones de café uva maduro y cantidades mínimas de café verde. El café comercial clasificado como maduro que se recibe en los beneficiados comerciales de Puerto Rico no cumple con esta condición, por lo que se requerirá de mayor esfuerzo para mejorar la recolección y la selección del café en el beneficiado para obtener café con las características óptimas de calidad para exportación.
Suplementación de vacas lecheras mediante apacentamiento en Leucaena leucocephala por 3 horas diarias durante la sequía y la época lluviosa
Authors: Michelet Mascary  , Paul F. Randel  , Ernesto Riquelme-Villagrán
Published: March 2022

Se usaron 26 vacas Holstein y Suiza Parda en dos experimentos, el primero (E-1) durante la época seca (febrero a abril) y el segundo (E-2) durante la época lluviosa (julio a septiembre). Se comparó el efecto de permitir 3 horas diarias de apacentamiento en bancos de proteína de leucaena y gramíneas asociadas (tratamiento L) y un testigo (T) basado en el apacentamiento de gramíneas únicamente. El forraje gramíneo que crecía solo no recibió fertilizantes y fue relativamente escaso durante la sequía y muy abundante durante las lluvias. Se dio suplementación individual con alimento concentrado (16% proteína bruta, PB) según el nivel de producción, pero fijando un máximo de 7 kg diarios. El diseño experimental fue de reversión singular de tratamientos con períodos comparativos de 21 días. Los tres forrajes, gramíneas solas, gramíneas asociadas y la leucaena, mostraron porcentajes medios de fracciones químicas en E-1 y E-2 de: PB, 5.9, 6.9 y 20.3; 7.3, 6.4 y 23.7; y fibra ácido detergente, 34.4, 34.3 y 28.2; 45.8, 44.3 y 27.6, respectivamente. Muestras de líquido ruminal de vacas en L y T arrojaron 179 y 148 mg/l de amonio en E-1 y 184 y 159 mg/l en E-2. No se notó un efecto consistente de los tratamientos sobre las concentraciones totales y proporcionales de los ácidos grasos volátiles ni sobre el pH del líquido ruminal. Las respuestas lactacionales con L y T fueron: leche diaria, 15.1 y 14.5 kg (P = 0.05) en E-1 y 15.6 y 15.6 kg en E-2; porcentaje de grasa, 3.1 y 3.2 en ambos experimentos; porcentaje de proteína, 3.7 y 3.6 y 3,2 y 3.3 en E-1 y E-2. El consumo de concentrado fue 5,6 y 5.7 kg y 6.5 y 6,4 kg; y el peso vivo fue 542 y 540 kg y 506 y 497 kg para L y T en el mismo orden. Se sugiere que el efecto positivo del banco de proteína sobre la producción de leche durante la época seca se debió a un mayor consumo de forraje.
Is There Any News Left after Gatekeeping? A Journalistic Perspective from Beijing on the Multi-Level of Analysis
Authors: Xu Nairui
Published: March 2022

This study looks at how investigative journalists practice gatekeeping in the context of China. By combining with the hierarchical model of influence (Shoemaker, 1991; Shoemaker & Reese, 2014), this study revisits the relationship between influential factors from the aspects of politics, markets, and organizations, which are across all the levels. Based on the interviews with 25 investigative journalists in Beijing, this research suggests that influential factors do not always have a strong hierarchical relation between each other regarding what sort of information could turn out to be news. This situation is because journalists share varied perceptions about what influential factor can convert into a particular constraint.
“Bowiemythomania” as a Phenomenon of Pop Culture: Organic Hybridity and Special Temporality in Creative Work of David Bowie
Authors: Ivanov Andrey G.
Published: March 2022

The article examines the features of constructing David Bowie’s mythology which has a pronounced hybrid character. The content analysis of D. Bowie’s works showed that he often used images that go back to classical mythological plots, and many popular songs and concepts of D. Bowie’s albums were created using mythologization mechanisms. The main creator of the myths was the performer himself, and the special mythological temporality constructed by the musician encompassed all modes of time, each of which could be correlated with a certain complex of myths. The specificity of such temporality in the case of D. Bowie was that it manifested itself in reverse chronological order: at the beginning of a career the future was mythologized, in the middle it was the present and at the end it was the past. Playing on various collisions of myth with reality and using the technique of myth reoccupation, D. Bowie demonstrated to the world all the creative power of “mythological reality”. It is noted that post-truth accompanied the musician’s career from the very beginning, contributing to the genuine disclosure of his talent. It is concluded that in relation to the heritage of D. Bowie, the term “hybrid mythology” acquires positive meaning. The singer manages to bring pop culture to a new level, giving rise to a phenomenon that we can call “bowiemythomania”.
Telegram Channels in the System of Expert and Political Communication in Modern Russia
Authors: Lyakhovenko Oleg I.
Published: March 2022

Political telegram-channels play an important role in maintaining political decision making and shaping the public agenda in modern Russia. Both features of the messenger itself (convenience, a low barrier to entry, a short “shoulder” of communication) and the specifics of the political system of modern Russia together with the predominance of non-public policy have prompted political elites to use indirect communication and anonymous instruments of political struggle. Furthermore, political telegram-channels are in demand as an instrument of expert communication and reflection about the current political situation. The purpose of the research is to analyse the features of political and expert communication in telegram-channels in Russia. It is concluded that, despite the objective predominance of manipulative content, telegram-channels form a special expert ecosystem, a kind of “distributed think tank” which analyses Russian internal political and international agenda in real time. Experts and analytical centres use telegram-channels to communicate their position both to decision makers and the general public. The main problem with the use of telegram-channels as an expert network and “distributed think tank” is to distinguish between manipulative and expert components. A widespread phenomenon of “formative analytics” (manipulative content which pretends to be an expertise) take place in telegram-channels. To solve this problem, we offer analytical tools that require high professional skills in working with information from a researcher, as well as the use of the professional reputation of the sources within the real expert community.
Safety profile of onasemnogene abeparvovec in children with spinal muscular atrophy
Authors: Kuzenkova Lyudmila M. , Uvakina Evgeniya V. , Popovich Sofiya G. , Podkletnova Tatyana V. , Nezhelskaya Aleksandra A. , Abdullaeva Luizat M. , Fisenko Darya A. , Naidenko Alena V.
Published: March 2022

Goal. To evaluate the safety profile of onasemnogene abeparvovec (Zolgensma®) gene therapy in children with spinal muscular atrophy (SMA) in real clinical practice. Materials and methods. The study included 30 SMA children who underwent gene replacement therapy with onasemnogene abeparvovec (Zolgensma®) from December 2020 to December 2021 at the Center for Pediatric Psychoneurology. All children had a diagnosis of SMA confirmed by molecular genetic methods, with no more than 3 copies of the SMN2 gene and the absence of antibodies to the adeno-associated virus serotype 9. The safety profile was assessed by monitoring the clinical and laboratory data of the patients after administration of onasemnogene abeparvovec. Clinical events included all changes in the child’s condition that could be associated with the administration of the drug (hyperthermia, decreased appetite, nausea, vomiting, stool disorders). Laboratory assessment included monitoring of complete blood count, biochemical blood tests, blood coagulation indices. The degree of laboratory changes was estimated according to common terminology criteria for adverse events (CTCAE version 5.0). Results. The safety profile of the drug Zolgensma® was studied in 30 children aged from 3 to 39 months, with a weight of 5.2 kg to 14.2 kg. Twenty-eight (93.3%) children had at least one clinical event associated with the administration of the drug. Hyperthermia was observed in 24 (80%) children, nausea and vomiting in 18 (60%) children, decreased appetite in 20 (66.7%) children, stool changes in 4 (13.3%) children. Monitoring of laboratory indices revealed thrombocytopenia and monocytosis in twenty-two (73.3%) children and neutropenia in twelve (40%) children in the general blood test. An increase in the level of transaminases was noted in all children, the CTCAE grade 1 was detected in fifteen (50%) children, the CTCAE grade 2 in 7 (23.3%) children, CTCAE grade 3 in 6 (20%) children, CTCAE grade 4 in 2 (6.7%) children. Children with CTCAE grade 3 required correction of the prednisone dose up 2 mg/kg per day for 2-4 weeks. Two children with CTCAE grade 4 required pulse therapy with methylprednisolone at a dose of 30 mg/kg per day. Regardless of the level of transaminases, no change in the level of total and direct bilirubin was observed in any case. A decrease in prothrombin time was observed in 14 (46.6%) children. An increase in the level of troponin I was detected in four (13.3%) children. In all cases of serious adverse events, according to laboratory indices, the clinical condition of the children remained stable. The average duration of prednisone intake was 17.8 ± 6.6 weeks. Conclusion. The safety profile of the drug onasemnogene abeparvovec (Zolgensma®) in real clinical practice in children with SMA is presented.
Quality of life of children with cystic fibrosis with disorders of carbohydrate metabolism
Authors: Lyabina Nadezhda V. , Chernikov Vladislav V. , Simonova Olga I. , Shirokova Irina V. , Smirnov Ivan E. , Sviridova Tatyana V.
Published: March 2022

Introduction. Cystic fibrosis (CF) is a hereditary, multisystem disease that is accompanied by numerous complications, which affects the quality of life (QOL) of patients, determining its duration and comfort. With an increase in the survival rate of CF patients, various concomitant diseases were identified, one of which is cystic fibrosis-associated (dependent) diabetes mellitus (CFDM). Traditionally, it is believed that CFDM worsens the patient’s QOL. To establish this, a questionnaire is conducted with validated questionnaires for children - Health Utilities Index (HUI). Objective: to determine the QOL in CF patients with disorders of carbohydrate metabolism. Materials and methods. There were surveyed sixty-four CF 5 to 18 year patients (Me = 13.59 years), including 42 girls and 22 boys. To diagnose disorders of carbohydrate metabolism, a standard oral glucose tolerance test (OGTT) was performed in all patients. According to OGTT data CF patients were divided into 3 groups: 1st - 25 cases without deteriorations of carbohydrate metabolism; 2nd - 25 children with prediabetes and 3rd - 14 CFDM patients on insulin therapy and without it. The assessment of the psychological state and development of CF patients with prediabetes and CFDM cases was carried out. The parameters of emotional well-being, attitude to the disease and adherence to treatment were studied. Results. The authors revealed no significant difference in the QOL in CF patients by all scales of the questionnaire. There was a tendency to decrease in QOL according to the overall score of the questionnaire (HUI3) in CF children with prediabetes (0.77 ± 0.18 units) compared with patients without carbohydrate metabolism disorders and CFDM patients (0.81 ± 0.14 units and 0.80 ± 0.14 units, respectively). In the emotional sphere, there is a tendency to decrease in QOL in patients with prediabetes and CFDM cases. The analysis of indices on separate scales revealed a more pronounced decrease in QOL on the emotion scale in CF patients with disorders of carbohydrate metabolism. CFDM patients are in a more severe psychological state than children with prediabetes. They are significantly more likely to experience psychophysical discomfort and tend to fixate on the symptoms of the disease (Fisher’s angular transformation criterion 3.11, p < 0.01). These patterns should be taken into account when analyzing the psycho-emotional state of a CF child for timely prevention and correction.
Crossing syndrome of gastroesophageal reflux disease and of dispepsia in schoolchildren of ethnic populations of Siberia
Authors: Polivanova Tamara V. , Kasparov Eduard V. , Vshivkov Vitaly A.
Published: March 2022

Introduction. An essential point in the prevention and risk assessment of these diseases is identifying their predictors predisposing to a progressive course of inflammation in the gastroduodenal zone, particularly gastroesophageal reflux disease (GERD) intersection syndrome and dyspepsia syndrome (DS). A more unfavourable situation is observed among the indigenous - Mongoloid populations. The aim of the study is to investigate the ethnic features of the prevalence and clinical manifestations of the intersection of GERD with DS in schoolchildren of Mongoloid and Caucasian populations of Tuva, Evenkia and Buryatia. Material and methods. A cross-sectional survey was carried out on the presence of gastroenterological complaints in schoolchildren aged 7-17 years, followed by random gastroscopy with a biopsy of the gastric mucosa. Six hundred forty one Caucasians, 894 Mongoloids were examined in the Republic of Tuva; in Buryatia, there are 168 Caucasians, 622 Mongoloids; in Evenkia, there are 993 Caucasians, 376 Mongoloids. Endoscopically examined: in Tuva, 122 Caucasians, 158 Mongoloids; in Buryatia - 28 Caucasians, 82 Mongoloids; in Evenkia, there are 133 Caucasians, 71 Mongoloid. Results. Among schoolchildren in the Siberian region, the prevalence of GERD overlap syndrome with DS was 4.7%. An increase in indices was noted among the Mongoloid populations: by 5.7% and 3.6% among Caucasians. Schoolchildren of Mongoloid populations with the overlapping syndrome often had a variant of dyspepsia with epigastric pain. At the same time, regardless of ethnicity, schoolchildren with intersection syndrome have an increased likelihood of forming erosive and ulcerative lesions of the mucous membrane of the gastroduodenal zone. Conclusion. The syndrome of overlapping in Siberian schoolchildren has a more unfavourable course with features in the ethnic populations of Mongoloids and Caucasians.
The Lively Science: A Book Reivew
Authors: Schmidt Ashley , Mitchell Megan
Published: March 2022

A book review on The Lively Science by Michael Agar, published in 2021. In this review, we examine the three underlying points around which Agar structures the book, then appraise the book from our lens as novice female researchers. We end the review by sharing a reading guide novice researchers could use to document their reading and understandings.
Impact of Covid-19 Pandemic on Dow Jones Index
Authors: Maheta Dhaval , Shah Jaini
Published: March 2022

Covid-19 pandemic emerged as a Black Swan event that has shaken the global economy. In the present study the researchers have tried to determine the Impact of Covid-19 pandemic on the US Stock markets using data of Covid-19 confirmed cases and closing price of Dow Jones Index over the period January 21,2020 to May 31,2020. To determine the relationship between covid-19 and US stock market Granger-Casualty test and Johnsen Co-integration test. The Study findings revealed that there is a short-term relationship between this two which means the Covid-19 pandemic has positive impact on price of stock market in a short run.
Chinese Yuan Per SDR During Covid-19
Authors: Bhowmik Debesh
Published: March 2022

In this paper, author seeks to explore the dominant determinants that would influence the behaviour of Yuan per SDR especially during the period of Covid-19 from 2020m1 to 2021m7 since Yuan enters into the SDR basket from October 2016.Author selected three dimensions such as dominant macro variables, exchange rates and important capital market indicators. The paper found that Yuan/US$ had great influence on Yuan per SDR rate, export, import and foreign exchange reserves which affected Yuan per SDR rate and market capitalization, number of listed companies, Shanghai Composite Index and interbank lending trading volume have significant impact on the Yuan per SDR during the specified period. The paper focus on the policies of capital account convertibility, exchange rate stability, more participation in interbank lending, balance the onshore and offshore RMB market, and strengthening capital market of China.
ENSURING ELECTROMAGNETIC COMPATIBILITY OF MICROPROCESSOR DEVICES
Authors: Popov Maxim G. , Melnikov Alexey A. , Mankov Petr N. , Dautov Azamat A.
Published: March 2022

The research is devoted to the problem of electromagnetic compatibility of toroidal chokes with microprocessor elements of printed circuit boards. The scientific novelty of the work lies in the determination of the most favorable option for the location of the chokes through the minimization function. The analysis of target vector functions and the most effective option is carried out. The purpose of the study is to determine the permissible location of the chokes, at which the electromagnetic interference, they create for the microprocessor elements of the printed circuit board, will be minimal. The object of the study is a printed circuit board of a microprocessor-based device for measuring the grounding resistance of supports of high-voltage power lines, in the power circuit of which toroidal chokes are used. The subject of this work is the electrophysical properties of toroidal chokes, which are sources of electromagnetic interference for microprocessor elements of control and measuring instruments. The research methodology consists in carrying out numerical experiments to calculate the electromagnetic field with subsequent analysis of the obtained vector functions of the magnetic field strength H on the board surface. The assessment of the influence of interference caused by chokes is carried out using the developed mathematical model and numerical methods for calculating the electromagnetic field. For computational calculations, the authors have developed a software algorithm implemented using the Delphi programming language. The choice of the mutual arrangement of the chokes on the microprocessor integrated circuit is carried out as a result of solving the optimization problem by the gradient method, taking into account the given restrictions on the condition of electromagnetic compatibility. To assess electromagnetic compatibility, a design model of a printed circuit board of a microprocessor device with toroidal chokes was developed. As a result of a numerical experiment, a method for automated determination of the location of toroidal chokes within an integrated microcircuit of resistance devices of the proposed control of electrodes of overhead power transmission line supports was tested. As a result of research, it was found that for electromagnetic compatibility of microelectronic devices, it is sufficient to place the toroidal chokes of power circuits closer to the corners of the printed circuit board. In other design cases, the EMC class 1 requirement is not met.
VIBRATION DIAGNOSTICS SYSTEM FOR ELECTRIC MOTOR WITH ACTIVE ULTRASONIC SENSING
Authors: Bychkov Anatoly V.
Published: March 2022

At present, part of the fixed assets of electric grid infrastructure is becoming obsolete in the Russian Federation. It leads to an inevitable decrease of operational reliability of single electrical equipment and power-supply systems as a whole. At the same time the requirement to the reliability for most electrotechnical complexes is the main one. As a result, diagnostics is the most important process in electrical equipment’s operation. Diagnostics is based on measurements, control and analysis of a large number of equipment’s characteristics and parameters. One of the important components of diagnostics is vibration control, as it allows detecting a large number of mechanical defects and defects in electrical or magnetic parts of electrical equipment. Vibration control, as a means of malfunctions diagnosis and ensuring the stable operation of electrical equipment, is most often carried out by contact sensors. The paper describes the experimentally tested vibration diagnostics system for an electric motor, which is based on remote ultrasonic measurements together with contact measurements. It is shown that remote measurements allow controlling moving elements and having more capabilities than contact ones. A significant difference between vibration signals obtained by different methods was found: using traditional contact sensors installed on the engine body and using active ultrasonic sensing of rotating elements. A comparative analysis of information obtained from contact and noncontact sensors is proposed for the diagnostics of electrical equipment. The analysis was carried out both in starting and steady state operation modes of the electric motor. The joint use of contact and remote measurements significantly increases the informative value and data reliability of technical condition forecasts.
NEURAL NETWORK SIGNAL PROCESSING WITH NONLINEAR DISTORTIONS IN A “SLIDING TIME WINDOW”
Authors: Andreev Oleg N. , Vasileva Lidia N.
Published: March 2022

Continuous monitoring of the signals harmonic components level in electrical networks is an important task in ensuring high-quality power supply to consumers. This applies to both normal and emergency power system operation modes. One of the nonlinear signal distortions sources in measuring devices are nonlinear operating transformers modes. Saturation effects and hysteresis phenomena in measuring current transformers make it difficult to identify the actual operating parameters of electric power equipment. The paper shows that the apparatus of artificial neural networks can be used to control the nonlinear distortions of industrial frequency signals. The proposed algorithm based on a direct propagation neural network is tested on the example of distortion of current signals in the secondary winding of a measuring transformer. It is shown that it is possible to determine the amplitude, frequency and phase of the signal harmonic components in a “sliding time window” with an accuracy of a few percent. Estimates of the required frequency and interval of signal digitization are made; a comparison is made using the discrete Fourier transform algorithm.
Management the Retraining of Management Competencies of the Deans in Vietnam’s Higher Education
Authors:   The dean in the faculty of Political Theory and Humanities Social Science, The University of Fire Prevention and Fighting, Ministry of Public Security of Socialist Republic of Vietnam 243 Khuat Duy Tien street, Thanh Xuan district, Hanoi, Vietnam, Hoang Thang – Ngoc
Published: March 2022

Managing competencies have been becoming the most important concern of the deans in the universities as the higher education of Vietnam has considerably integrated into the world’s education with quite a few challenges from within. This research represents the results of how organizational activities of the retraining for the deans in the universities have been carried out by questioning people working in some of the higher education institutions. Findings show that management competencies’ retraining has achieved many achievements, but there are some actions that could be taken to improve the quality of this activity these days.
Mood and perceived social support of Colombian older adults with chronic obstructive pulmonary disease during the pandemic: A cross-sectional descriptive study
Authors: Restrepo Jorge Emiro , Ospina-Bran Zaira Eliana , Cuartas-Montoya Gina Paula
Published: March 2022

Background: During the pandemic, older adults have been one of the most vulnerable groups. Having a clinical diagnosis of COPD significantly increases the likelihood of poor clinical outcomes in patients with COVID-19, so these patients should be considered a high-risk group. From a positive mental health perspective, it is important to know patients’ moods and perceived social support.
No depression for my old heart, before and after the event
Authors: de Lima Michele , Escobar Guzmán Luis Fernando , Escobar Guzmán Cristian Andrés , Lanz-Luces José Ramon , Lanz-Souquett José Daniel
Published: March 2022

Background: Depression and cardiovascular diseases (CVD) are highly prevalent in the elderly. Depression could be a CVD risk factor as well as an ailment sequela. Objective: To review diagnostical, pathophysiological, and therapeutic factors involved in depression-cardiovascular diseases. Methods: The research was carried out using the keywords of a 10-years range of published studies in Portuguese, English, and Spanish from Scielo and PubMed databases. Inclusion criteria: In vitro studies, cohort studies, case-control, and clinical trials. Studies out of time range, mean age <60 years, other psychiatric diseases were excluded.
Dosis elevadas de vasopresina en choque séptico. Reporte de caso y revisión de literatura
Authors: García Regalado Jacob , Montalvo Aguilar Michell Estrella , Martínez Pantoja Axayacatl Carlos , González López César Augusto
Published: March 2022

Las guías “surviving sepsis” recomiendan vasopresina como tratamiento de segunda línea en choque séptico a dosis de 0,03 UI/min. Mayores dosis han sido utilizadas en estudios clínicos y podrían resultar benéficas en choque persistente. Caso clínico: Muje de 32 años. Ingresó por choque séptico secundario a colangitis severa. Requirió norepinefrina a 52 μg/min y vasopresina a 0,13 UI/min. Logró recuperación clínica satisfactoria. Conclusión: Utilizar vasopresina a dosis mayores de las recomendadas en “surviving sepsis” es una alternativa en pacientes sin respuesta a tratamiento convencional
A propósito de la hemofilia. ¡Tanto sufrimiento merece un final ético!
Authors: García de Insausti Carmen L
Published: March 2022

La hemofilia es una enfermedad hereditaria que afecta la coagulación. Esto puede ocasionar hemorragias espontáneas, después de una operación o de una lesión. Cada 17 de abril se conmemora el Día Mundial de la Hemofilia, elegido así por la Federación Mundial de Hemofilia en honor al día de nacimiento de su fundador, Frank Schnabel. Se trata de un día en el que se pretende conseguir sensibilizar y concientizar a la población mundial sobre la enfermedad y lograr compartir conocimientos e investigación para mejorar la calidad de vida de los pacientes con esta enfermedad.