bluuebunny/crossref_metadata_2025 huggingface dataset:
Motivasi Berwirausaha Mahasiswa Pendidikan Ekonomi FKIP Universitas Palangka Raya
Authors: Alexandro Rinto , Hariatama Fendy , Baboe Kuwing , Uda Tonich , Erang Dehen , Lianto Jefri
Published: July 2022

Jenis penelitian ini adalah penelitian deskritif. Tehnik pengumpulan data yang digunakan yaitu: observasi, wawancara, dokumentasi. Analisis data melalui: 1) pengumpulan data, 2) reduksi data, 3) penyajian data, 4) penarikan kesimpulan. Hasil penelitian: 1) motivasi berwirausaha mahasisiswa pendidikan ekonomi yang nyaitu keinginan untuk berwirausaha Persentase yang memiliki motivasi mahasiwa dalam berwirausaha yang ada 10 mahasiswa yang setuju dan ada 15 mahasiswa yang netral. Hal ini dapat dimaklumi mengigat tidak semua diorientasikan untuk berwirausaha, seperti fakultas FKIP Prodi Pendidikan Ekonomi yang lulusannya akan mengajar dan sebagai guru saat akan lulus. Karena disiplin ilmu yang didapatkannya lebih berorientasi untuk menjadi pengawai Negeri. Berdasarkan uji perbedaan motivasi mahasiswa untuk berwirausaha berdasarkan orang tua pada umunya anak banyak menerima nilai-nilai dan prinsip hidup dari orang tuannya. Berdasarkan kuisoner dapat dilihat bahwa pekerjaan manyoritas diminati oleh mahasiswa Pendidikan Ekonomi 2015 dan 2016 adalah menjadi Pengawai Negeri Sipil (PNS). Motivasi Mahasiswa Pendidikan Ekonomi untuk berwirausahaan berdasakan mata kuliah kewirausahawaan, diperoleh hasil bahwa tidak ada perbedaan yang senifikan motivasi Mahasiswa untuk berwirausahaan berdasarkan wirausahaan. Hal ini mengambarkan bahwa bagi mahasiswa (responden) yang sudah pernah belajar dan mengikuti praktek kewirausahaan, motivasinya tidak ada berbeda untuk berwirausahaan.
Manajemen Badan Usaha Milik Desa (BUMDES) Kebaron Mandiri Makmur Desa Kebaron Kecamatan Tulangan Kabupaten Sidoarjo
Authors: Rahmania Salsabella Nanda , Kriswibowo Arimurti
Published: July 2022

Sebuah Manajemen dalam pengelolaan BUMDes ini sangat penting karena dapat dijadikan sebagai acuan dalam pengembangan BUMDes serta dapat menangani beberapa permasalahn yang terjadi. Penelitian ini bertujuan untuk mengetahui proses Manajemen Badan Usaha Milik Desa (BUMDes) Kebaron Mandiri Makmur Desa Kebaron Kecamatan Tulangan Kabupaten Sidoarjo. Metode yang digunakan dalam penelitian adalah metode kualitatif menggunakan analisis deskriptif. Sumber data yang digunakan dalam penelitian ini adalah data primer dan data sekunder. Teknik pengumpulan data dalam penelitian ini yaitu observasi, wawancara, dan dokumentasi. Teori yang digunakan dalam penelitian ini menggunakan 4 indikator yaitu perencanaan, pengorganisasian, kepemimpinan, dan pengendalian upaya. Berdasarkan hasil penelitian ini mengenai Manajemen Badan Usaha Milik Desa (BUMDes) Kebaron Mandiri Makmur Desa Kebaron Kecamatan Tulangan Kabupaten Sidoarjo, masih belum optimal karena dari setiap indikator proses manajemen memiliki kendala masing-masing. Maka dari itu, dengan adanya kendala dalam proses manajemen dapat menghambat perkembangan BUMDes Kebaron Mandiri Makmur.
Pengaruh Serum yang Disimpan Selama Lima Hari Suhu 2-8°C dengan Serum yang Diperiksa Langsung pada Pemeriksaan Kolesterol Total
Authors: Pratiwi Chalies Diah , Hariyanto Hariyanto , Hermawati Andyanita Hanif , Fajrin Intan Niawati
Published: July 2022

Examination of blood cholesterol at this time became the trend of laboratory examination that much in demand by most people because of many diseases caused by hypercholesterolemia due to wrong diet or high cholesterol levels. Damaged equipment, reagent exhaustion, a large number of samples, laboratory distance with the sampling site too far, and power outages resulted in delayed laboratory examination that required sample storage. This study aimed to determine the effect of serum storage for five days with a serum examined directly to examine total cholesterol. The research design used was an experiment. The population in this research is all female students; Level 3 Study Program D3 Health Analyst STIKes Hutama Abdi Husada Tulungagung, using the Purposive sampling technique, counted 15 respondents. This research was conducted in May 2018. The data obtained were processed using SPSS 16 software and analyzed by Paired t-Test. This study showed the average value of total cholesterol levels in serum examined directly at 163 mg/dl while stored for five days temperature of 2-8 ° C at 158 mg/dl. After the paired test obtained value of P-value = 0.000, so P-value = 0.000 <α = 0.05, it can be concluded there is an influence between total cholesterol levels are checked directly and stored for five days temperature 2-8°C. Five days of serum storage affects the results of total cholesterol tests that lead to a decrease in total cholesterol, but the reduction is insignificant.
Kesiapan Tenaga Kesehatan dalam Menghadapi Bencana pada Tahap Mitigasi di Puskesmas Sitiarjo Kabupaten Malang
Authors: Nengrum Lilis Sulistiya
Published: July 2022

Indonesia has tremendous disaster potential, from floods, landslides, earthquakes, fire eruptions, prolonged droughts, hurricanes, and fires. Mitigation is to reduce the risks posed by disasters. Disaster mitigation focuses on reducing the impact of threats to reduce the likelihood of adverse effects from disasters. A health worker is any person who devotes himself to health and has knowledge and skills through education in health and for certain types requires the authority to undertake health efforts. This study aims to describe health workers in dealing with disasters at the mitigation stage at the Puskesmas Sitiharjo-Sumbermanjing Wetan Malang Regency. This research uses Cross Sectional research method. The treatment of this research is by giving questionnaires to respondents. The analysis of the readiness level of health personnel in the face of ready-prepared disaster risk reduction is 88%, ready enough 12%, and at the prevention of ready disasters 84%, ready enough 16%, and on education and training disaster prepared 12%, quite ready 88%, And in disaster preparedness planning that is ready 88%, ready enough 12%. This study found that health workers are less in the education and training category. Based on the results of this study can be advised puskesmas Sitiarjo for training education for health workers.
Cover, Content, and Editorial Note from Borneo J Med Lab Tech Vol. 4 No. 2 April 2022
Authors: Borneo J Med Lab Tech Chief Editor Of
Published: July 2022

Assalamu’alaikum Wr. Wb.

Alhamdulillahirabbil ‘alamin. After a long wait of almost 12 years from the first stand, the scientific journal of the Department of Analyst Health (Medical Laboratory Technology) Universitas Muhammadiyah Palangkaraya can be published. BJMLT is published every 6 months (2 issues/year) every October and April. The aim of this journal is to publish high-quality articles dedicated to all aspects of the latest outstanding developments in the field but not limited to Blood transfusion, Clinical Chemistry, Hematology, Histopathology, Immunology, Microbiology, Parasitology, Toxicology, Food and Beverage Analysis, Molecular Biology, Medical Biology, and related fields that are of interest to medical laboratory technologies, such as epidemiology, health promotion, professional ethics, and laboratory management, It was first published online in October 2018 using Open Journal System (OJS) 3.1 platform with e-ISSN 2622-6111 by URL http://journal.umpr.ac.id/index.php/bjmlt.

This edition contains 5 articles on Hematology, Microbiology, Clinical Chemistry, and Epidemiology. Editorial boards are fully aware that there is still room for improvement in this edition, hence with all humility, willing to accept constructive suggestions and feedback for improvements to the publication for the next editions.

The publication of BJMLT certainly participates in disseminating the results of research and review of science and technology development conducted by lecturers and researchers from UM Palangkaraya and other universities.

The editorial board would like to thank the University, all editors and reviewers, and contributors of the scientific articles who have provided the repertoire in this issue. We hope that all parties, especially the contributors of the articles, could re-participate in the publication's success in the next edition in October 2022.

Wassalamu’alaikum Wr. Wb.
The Effect of Board Characteristics on the Relationship between Managerial Overconfidence and Audit Report Lag: Evidence from Korea
Authors: Oh Hyun Min , Jeon Heung Joo
Published: July 2022

This study aimed to empirically analyze the effect of board characteristics on the relationship between managerial overconfidence and audit report lag. Managerial overconfidence was measured according to the method proposed by Schrand and Zechman (2012). The study sample comprised 4,179 firm-year observations listed on the Korea Composite Stock Price Index from 2011 to 2017. The results of the analysis were as follows. First, there was a significant positive correlation between managerial overconfidence and audit report lag. Second, the larger the board size, the more it mitigated the relationship between managerial overconfidence and audit report lag. Third, as the ratio of outside directors on the board increased, the positive relationship between managerial overconfidence and audit report lag decreased. This study is meaningful because it directly examined how the complex relationship between the characteristics of managers and the characteristics of the board of directors affects audit report lag. Managerial overconfidence increased the firm's audit risk and acted as a determinant of audit performance, and, by suggesting that it results in an increase in audit effort, the results of this study have implications for supervisory agencies, auditors, and audit target companies. In addition, the study is meaningful because it suggests that the characteristics of the board of directors can reduce audit risk by functioning as an excellent corporate governance structure.
“La mirada de género y la percepción de la seguridad de los destinos turísticos: el caso de Girona”
Authors: Serra Simón Jordi , Espinosa Mirabet Sílvia , Ribes Guàrdia Francesc Xavier
Published: July 2022

Resumen y abstract. 

La seguridad es uno de los aspectos esenciales cuando se visita e interactúa con un destino turístico. Evaluar la seguridad percibida permite entender las sensaciones de los visitantes de una ciudad y comprender en qué medida sienten que su experiencia en esa ciudad es segura y, por tanto, mejor. 

La presente investigación analiza la seguridad percibida en un destino urbano bajo la perspectiva de género y considerando la procedencia de las personas participantes. El estudio realizado se fundamentó en el uso una escalera Likert para que los y las visitantes de Girona valoraran la seguridad que habían percibido en su estancia en esa ciudad. Los principales resultados indican que existen ligeras diferencias en la percepción de seguridad según el género de los participantes. No obstante, este factor no implica un cambio drástico en las valoraciones globales de los turistas sobre la capital. A modo de conclusión, en el estudio se presentan posibles soluciones y áreas de mejora para lograr que el destino se perciba como un lugar todavía más seguro para los turistas, y por lo tanto que los visitantes disfruten más de su estancia. 
Substituting, Differentiating, Discriminating! Migration and Cognitive Borders in Aging Societies
Authors: Maniglio Francesco
Published: July 2022

Both Legislators and demographers have shown concerns about the aging of populations in the global North countries, and, for over two decades, have suggested encouraging migrations to make up for its effects. As a result, qualified and highly qualified migration have boomed, reflecting the global consolidation of migrant labor in technological, scientific and financial sectors. This substitution migration policy, however, is put into question from a knowledge-based economical and political perspective, since, by disregarding the relationship between labor productivity transformations and demographic crisis, it fails to see important processes whereby immigrants are differentially included. Moreover, we want to reject the philanthropic and optimistic views of globalization, as consolidated in formulations such as “brain gain” and “brain circulation”, which emphasize the generalized positive effects of qualified workers’ migration. Instead, we suggest delving into the cognitive injustice of international migration processes, which are part of a greater global social injustice pattern. Indeed, rather than reproducing the discourse of mobility, democracy and human rights, we assert that selective immigration policies effectively consolidate the reproduction of global social inequalities.
The Confluence Between COVID-19 and Informal Externalisation Agreements and the Precarious State of the Right to Seek Asylum
Authors: Ashraf Tasawar
Published: July 2022

The swift closure of international borders with the outbreak of the COVID-19 pandemic has placed the right to seek asylum in a precarious position. The paper questions the impact of COVID-19 on the right to seek asylum in the face of the informal externalisation agreements (IEA) concluded by the European Union (EU) Border States and other destination states to shift border management to neighbouring transit states. The paper argues that IEA marginalised the right to seek asylum well before the outbreak of COVID-19. The pandemic's impact on the right to seek asylum, per se, is temporal, which can be defused through enhanced procedural measures. However, in the long run, COVID-19 provides an alibi to the Border States to further externalise asylum and migration controls through IEA. Thereby, COVID-19, along with IEA, is highly likely to make the right to seek asylum obsolete.
PENGEMBANGAN LEMBAR KERJA PESERTA DIDIK (LKPD) FLUIDA STATIS DENGAN SCIENTIFIC APPROACH UNTUK MENINGKATKAN KETERAMPILAN BERPIKIR KRITIS SISWA SMAN KOTA BENGKULU
Authors: Sari Rensi Purnama , Sakti Indra , Hamdani Dedy
Published: July 2022

ABSTRAK Penelitian ini bertujuan untuk menghasilkan Lembar Kerja Peserta Didik (LKPD) Fluida Statis dengan Scientific Approach untuk meningkatkan Keterampilan Berpikir Kritis Siswa SMAN Kota Bengkulu. Penelitian ini merupakan jenis penelitian pengembangan (Research and Development) dengan tipe rancangan level 1 yang terdiri dari 5 tahapan, yaitu: 1) potensi dan masalah 2) studi literatur dan pengumpulan informasi 3) desain produk 4) validasi desain 5) desain teruji. Validasi desain dilakukan oleh 2 judgement ahli dan 2 praktisi untuk menilai produk yang dikembangkan dari aspek kelayakan isi, penggunaan bahasa, penyajian dan kegrafisan. Berdasarkan hasil uji validitas aspek kelayakan isi 87,5% dengan kategori sangat baik, aspek penggunaan bahasa didapatkan hasil persentase sebesar 83,4% dengan kategori sangat baik, aspek penyajian sebesar 89,1% dengan kategori sangat baik dan aspek kegrafisan sebesar 93,8% dengan kategori sangat baik. Berdasarkan hasil tersebut, dapat disimpulkan bahwa LKPD fluida statis dengan scientific approach untuk meningkatkan Keterampilan berpikir kritis siswa SMAN kota Bengkulu yang dikembangkan sudah valid dan merupakan desain teruji dengan persentase total uji validitas yaitu 88,5% yang termasuk dalam kategori sangat baik.Kata Kunci: LKPD, scientific approach, keterampilan Berpikir Kritis.ABSTRACTThis research was aimed to made the static fluid of student worksheet with the scientific approach to increase the critical thinking skill of the public high school student in Bengkulu. The research type was the Research and Development type that was the designed type was level 1 divided into five steps that is 1) a potency and problem, 2) literature study and information collecting, 3) a product design, 4) a design validation, 5) a design proved. The design validation was conducted by two judgments and two practitioners to test a product that developed both content appropriateness, the use of language, presentation, and graphics. Based on the  result of the validation test, the content appropriateness aspect got 87,5% (very well), the presentation aspect got  89,1% (very well),  the graphic aspect got 93,8% (very well). Based on that result, it could be concluded that the static fluid of student worksheets with the scientific approach to increasing the critical thinking skill of the public high school student in Bengkulu that developed has valid and proved with the total percentage test got 88,5% (very well).Keyword: The static fluid of student worksheet, scientific approach, critical thinking skill.
PENGEMBANGAN PERANGKAT PEMBELAJARAN MODEL COOPERATIVE PROBLEM SOLVING UNTUK MELATIHKAN KETERAMPILAN PEMECAHAN MASALAH SISWA
Authors: Sari Irma Permata , Sutarno Sutarno , Swistoro Eko
Published: July 2022

ABSTRAKPenelitian ini yang bertujuan untuk mendeskripsikan kelayakan dan karakteristik perangkat pembelajaran model cooperative problem solving untuk melatihkan keterampilan pemecahan masalah siswa pada materi momentum dan impuls. Model pengembangan yang digunakan pada penelitian ini adalah model pengembangan 4D, yaitu define, design, develop dan disseminate namun hanya dilakukan sampai tahap develop. Validasi dilakukan oleh 3 judgement ahli untuk menilai produk yang dikembangkan. Kelayakan perangkat pembelajaran ini menurut nilai rata-rata hasil uji validasi ahli yaitu kelayakan RPP adalah 89% dalam kategori sangat layak, kelayakan LKS 91% dalam kategori sangat layak dan kelayakan soal tes 89% dalam kategori sangat layak dengan nilai rata-rata keseluruhan 90% dalam kategori sangat layak sehingga dapat disimpulkan bahwa perangkat pembelajaran yang dikembangkan sudah layak, dengan karakteristik perangkat pembelajaran antara lain: RPP menggunakan langkah-langkah kegiatan pembelajaran model cooperative problem solving, LKS yang berisi kegiatan praktikum dengan langkah-langkah penyelesaian masalah yang bertujuan melatihkan keterampilan pemecahan masalah siswa dan soal tes beserta jawaban atau penyelesaian soal yang melatihkan keterampilan pemecahan masalah siswa.Kata kunci: penelitian dan pengembangan, perangkat pembelajaran, cooperative problem solving, keterampilan pemecahan masalahABSTRACTThe research aimed to describe the feasibility and characteristics of a cooperative problem solving model of learning tools to train students' problem solving skills in momentum and impulse material. The development model used in this research is the 4D development model, namely define, design, develop and disseminate but only done until the develop stage. Validation is carried out by 3 expert judgments to assess the product being developed. The feasibility of this learning device according to the average value of the expert validation test results, namely the feasibility of the RPP is 89% in the very feasible category, the feasibility of the LKS 91% in the very feasible category and the feasibility of the test questions 89% in the very feasible category with an overall average score of 90% in the very feasible category so it can be concluded that the learning tools developed are feasible, with the characteristics of the learning tools, among others: RPP uses the steps of learning activities in the cooperative problem solving model, worksheets containing practicum activities with problem solving steps aimed at practicing solving skills student problems and test questions along with answers or problem solving that practice student problem solving skills.Keywords: Research and development, learning tools, cooperative problem solving, problem solving skills
PEMBELAJARAN APBRA BERORIENTASI INVITATION IN TO INQUIRY SEBAGAI ALTERNATIF SOLUSI PEMBELAJARAN SAINS BAGI SISWA TUNAGRAHITA
Authors: Wardana Rendy Wikrama , Buyung Buyung
Published: July 2022

ABSTRAK Terbatasnya penelitian yang mengkaji pembelajaran sains bagi siswa Tunagrahita pada konteks metode pembelajaran. Tujuan penelitian ini adalah menggambarkan alternatif metode pembelajaran sains bagi siswa tunagrahita. Penelitian merupakan penelitian kualitatif dengan desain studi pustaka atau literature review. Pengumpulan data dilakukan melalui kajian dan sintesis terhadap sumber-sumber referensi bacaan baik artikel jurnal, buku maupun referensi terkait Pembelajaran APBRA dan metode Invitation in to inquiry. Analisis data dilakukan dengan menganalisis dan sintesis jurnal yang kemudian ditarik sebuah kesimpulan. Hasil penelitian menunjukkan beberapa metode pembelajaran yang dapat menjadi alternatif dalam pembelajaran sains bagi siswa Tunagrahita. Alternatif metode pembelajaran sains bagi siswa tunagrahita yakni APBRA dan invitation in to inquiry..Kata Kunci : Pembelajaran, APBRA, Invitation in to inquiry, Sains, Tunagrahita ABSTRACT The Limited research that examines science learning for mentally retarded students in the context of learning methods.This research aims to description of Alternative science learning methods for Tunagrahita students. This research was qualitative research with literature review design. Data collection was conducted by collecting some literatures either articles or books  related to APBRA and invitation in to inquiry method. Data analysis was done by conducting analysis and articles and books synthesis and then drew a conclusion. The research results show that some learning methods can be an alternative in science learning for Tunagrahuta students. Alternative science learning methods for Tunagrahita students are APBRA and invitation in to inquiry. Keywords— Learning, APBRA, Invitation in to inquiry, Sains, Tunagrahita
The Analysis of Concept of Workplace and Undertaking in terms of Competence for the Collective Labor Agreement
Authors: GÖKTAŞ Seracettin , YILMAZ Gökhan
Published: July 2022

Collective labor agreement is the most important instrument to protect and improve the rights and interests of the members of the trade union. In this sense, the first aim of the trade union which commences organisation in workplace or enterprise, is to sign in the shortest time a collective agreement. Having considered that objection to determination of competence for the collective labor agreement ceases the competence process, it is important determine competence in the most appropriate way. With the Trade Unions and Collective Labor Agreement Law no 6356, the provision requires more than half of the workers employed in the workplace still remains for the collective labor agreement the majority that must be ensured in terms enterprise collective labor agreement is regulated as forty percentage. Accordingly, it has gained great importance to determine whether more than one unit in the same branch of activity belonging to the employer is in the nature of a single workplace or enterprise. In our study, this situation, which constitutes an important problem in practice, has been discussed and the current case law of Court of Cassation has been evaluated.
Analisis pengelolaan sampah organik menjadi gas metan (CH4) dan persepsi masyarakat terhadap pemanfaatannya di Tempat Pembuangan Akhir (TPA) Talangagung Kabupaten Malang
Authors: Al Fattah Muhammad Haris , Laili Saimul , Tito Sama' Iradat
Published: July 2022

The potential of methane gas in the landfill can be a source of renewable energy to meet the energy needs of the people of Malang City. The potential for methane gas for fuel that has been used is currently around 3% to 5% of the existing potential. Based on information from the Department of Hygiene and Landscaping, Malang City Government has provided gas connection pipes including stoves for free to 59 houses in 2012 and 408 houses in 2013. This study uses tools and materials, namely questionnaires to obtain perception data from the public or respondents, digital cameras for documentation, documents on the use of methane gas at the Talangagung TPA, and stationery. The results of interviews with biogas managers show that the management of organic waste into methane gas is an alternative gas (biogas) used by the community in the TPA (Final Disposal Site) Kepanjen Malang Regency This is applied based on an energy utilization system (energy waste). Based on the results of the Percentage Graph, it states that the percentage of people's perceptions who answered the questionnaire on average showed strong or very high scores, very high and/or very strong scores were almost indicated in all respondents' answers.Keywords: Methane Gas, Perception, Talangagung LandfillABSTRAKPotensi gas metan di TPA dapat menjadi sumber energi terbarukan untuk memenuhi kebutuhan energi penduduk Kota Malang. Potensi gas metan untuk bahan bakar yang sudah dimanfaatkan saat ini sekitar 3% sampai 5% dari potensi yang ada. Berdasarkan keterangan dari Dinas Kebersihan dan Pertamanan Kota Malang, Pemerintah Kota Malang sudah memberikan pipa sambungan gas termasuk kompornya secara gratis kepada 59 rumah pada tahun 2012 dan 408 rumah pada tahun 2013. Penelitian ini menggunakan alat dan bahan yaitu kuesioner untuk mendapatkan data persepsi dari masyarakat atau responden, kamera digital untuk dokumentasi, dokumen pemakaian gas metan di TPA Talangagung dan alat tulis. Hasil wawancara dengan pihak pengelola biogas menunjukkan bahwa pengelolaan sampah organik menjadi gas metana sebagai gas alternatif (biogas) yang digunakan oleh masyarakat di TPA (Tempat Pembuangan Akhir) Kepanjen Kabupaten Malang ini di terapkan berdasarkan sistem pemanfaatan energi (waste to energy). Berdasarkan hasil Grafik Presentase menyatakan bahwa presentase persepsi Masyarakat yang menjawab kuesioner secara rata-rata menunjukan nilai kuat atau sangat tinggi, nilai sangat tinggi dan/atau sangat kuat hampir ditunjuk pada semua jawaban responden.Kata kunci : Gas Metan, Persepsi, TPA Talangagung
PEMANFAATAN MASSIVE OPEN ONLINE COURSES DALAM PEMBELAJARAN AL QUR’AN DI ERA DIGITAL
Authors: Rokhim Ahmad Abdur , Rusydiyah Evi Fatimatur
Published: July 2022

This article aims to discuss the use of Massive Open Online Course (MOOC) media in learning the Qur'an in the digital era. The research method used in this study is a descriptive qualitative approach. In the current era, technological developments have brought the world of education to think about issuing learning innovations that are ready to meet the demands of the times. This includes online-based open courses or commonly referred to as Massive Open Online Courses (MOOC). The success of several MOOC platforms in providing various courses, such as English, Mathematics, Management, Physics, Graphic Design and so on is read as an opportunity also to develop online and open learning of the Qur'an. The use of MOOC media will be able to accommodate a large number of participants from various regions. This opportunity was then responded by several educational institutions to provide an online and open Qur'an learning platform, such as the Intensive Tahfidz, Griya Al Qur'an, Baitul Qur'an Daarul Qur'an, Tahsin Online Academy, and Qur'an Edu Center.
The Double Poles Methodology of Islamic Studies Fazlur Rahman
Authors: Almahfuz Almahfuz , Hitami Munzir , Anwar Abu
Published: July 2022

The view of Islamic education in delivering its students to become normative theologically oriented human beings so far has developed, it must redesign its learning methodology to be contemporary modernist, namely trying to continue to strengthen spiritual morals which is a product of the theological pole as well as strengthen scientific knowledge, namely the merging of the two poles. Therefore, it is necessary to study the thoughts of Islamic education thinkers from time to time in the hope that they can be used as material for thoughts, comparisons and references so that quality Islamic education can be realized as a model for general education that has been secular oriented. Fazlur Rahman is one of the originators of contemporary Islamic education thought. he stated that Muslims should be able to combine the two poles of education by integrating secular Western education into Islamic education learning. This thought is known as the Islamization of secular education in the world of Islamic education. So that the pole of empirical knowledge found by practitioners of secular education related to the needs of human life at that time must be accepted and based on the value of religious spirituality
THE ROLE OF VIDEO CALLS AS FACILITATORS IN PAI STUDENT THESIS SESSIONS
Authors: Cahyono Guntur , Marwanto Marwanto , Hammam Hammam
Published: July 2022

Video calls are the best way to be an easy facilitator in conducting thesis trials. The purpose of this study is to describe the role of video calls as a facilitator in a thesis trial. This research is a qualitative descriptive study. Technical data collection using interviews, documentation, and observation. Data were analyzed using reduction, presentation, and conclusion techniques. The subjects of this study were students of Islamic Religious Education (PAI). This research is located at the Faculty of Tarbiyah and Teacher Training IAIN Salatiga. The results of this study indicate that video calls provide a role as a facilitator in providing services and replace the role of offline thesis hearings. This research implies that during the pandemic, the thesis trial can still be done online using video calls so that the academic calendar can still run.
TEACHER FLEXIBILITY IN APPLYING THE AIR LEARNING MODEL TO OVERCOME SLOW LEARNERS IN MADRASAH
Authors: Mudarris Badrul , Nu'man Agus , Wahyuni Dewi
Published: July 2022

TProblems that occur in MTs Zainul Anwar precisely in class VII students have the characteristics of being difficult to absorb information as a whole due to limited cognitive abilities like poor thinking skills, difficulty with thinking and memory, and uncontrollable the emotion. The purpose of this study is to describe teachers' flexibility in overcoming the slow learner class VII MTs Zainul Anwar through the Auditory, Intellectually, And Repetition model. This research uses qualitative research methods with case study research. Analysis of the data used is the Miles and Huberman Interactive analysis model. The results showed. The teacher's flexibility in applying the AIR learning model is the teacher's efforts through adjustment, technical assistance (additional learning) with a mind mapping, remedial education, and a continuous evaluation with self-monitoring techniques. So, with the teacher's flexibility in applying the AIR learning model, he overcame the slow learner class VII MTs Zainul Anwar. Teachers can use the AIR learning model by using additional classes to make it easier for students to understand the learning material. In addition, it can develop student competence both cognitively and effectively to help improve student learning outcomes.
THE CONTRIBUTION OF TRADITIONAL GAMES IN ESTABLISHING SELF-CONTROL CHILDREN
Authors: Wardani Bernadeta Tri Anjarwati Kusuma , Nugrahanta Gregorius Ari
Published: July 2022

This research intended to develop a traditional game guidebook to improve self-control for children aged 9-12. This research method was R&D. Research conducted involved seven validators for expert judgment, seven teachers who were certified educators for needs analysis, and six children through subjects of a limited trial of the developed traditional game guidebook. The results indicated that; 1) development of this traditional game guidebook using ADDIE, 2) traditional game guidebook belonging to the "Very good" quality strata, with an average of 3.81 (scale 1-4) and consideration "No revision needed", and 3) implementation of this traditional game guidebook affected self-control. The significance test indicated t(5) = 16.81; p = 0.00 (p < 0.05) and r = 0.99 which belonged in the strata "Big effect" and equivalent to 98.26%. Thus, this traditional game guidebook could interpret 98.26% of changes in the self-control of children. The traditional game guidebook showed the effectiveness of the N-gain score of 80.39% which corresponds to the "High" strata.
Molecular mechanisms and functions of pyroptosis in sepsis and sepsis-associated organ dysfunction
Authors: Wen Ri , Liu Yong-Ping , Tong Xiao-Xu , Zhang Tie-Ning , Yang Ni
Published: July 2022

Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to infection, is a leading cause of death in intensive care units. The development of sepsis-associated organ dysfunction (SAOD) poses a threat to the survival of patients with sepsis. Unfortunately, the pathogenesis of sepsis and SAOD is complicated, multifactorial, and has not been completely clarified. Recently, numerous studies have demonstrated that pyroptosis, which is characterized by inflammasome and caspase activation and cell membrane pore formation, is involved in sepsis. Unlike apoptosis, pyroptosis is a pro-inflammatory form of programmed cell death that participates in the regulation of immunity and inflammation. Related studies have shown that in sepsis, moderate pyroptosis promotes the clearance of pathogens, whereas the excessive activation of pyroptosis leads to host immune response disorders and SAOD. Additionally, transcription factors, non-coding RNAs, epigenetic modifications and post-translational modifications can directly or indirectly regulate pyroptosis-related molecules. Pyroptosis also interacts with autophagy, apoptosis, NETosis, and necroptosis. This review summarizes the roles and regulatory mechanisms of pyroptosis in sepsis and SAOD. As our understanding of the functions of pyroptosis improves, the development of new diagnostic biomarkers and targeted therapies associated with pyroptosis to improve clinical outcomes appears promising in the future.
Addressing the food security and conservation challenges: Can be aligned instead of apposed?
Authors: Jouzi Zeynab , Leung Yu-Fai , Nelson Stacy
Published: July 2022

This perspective article provides an overview of the interaction between food security and conservation as two of the most important challenges of our time. To provide a better understanding of the topic, a conceptual framework for the possible pathways of positive and negative impacts of protected areas (PAs) on four dimensions of food security is proposed. Considering the importance of hunting and shifting agriculture in food security and the challenges caused by them in conservation, the cases of hunting and shifting agriculture were explored. Finally, the rights-based approaches in conservation and food security, as a new approach with the potential to protect people and the planet as a synergistic approach is discussed.
Sexual dimorphic effects of igf1 deficiency on metabolism in zebrafish
Authors: Zeng Ningmei , Bao Jiankang , Shu TingTing , Shi Chuang , Zhai Gang , Jin Xia , He Jiangyan , Lou Qiyong , Yin Zhan
Published: July 2022

Insulin-like growth factor 1 (IGF1) is an essential effector of the growth hormone (GH)/IGF1 axis for somatic growth regulation in mammals. However, its functions have not been thoroughly investigated in zebrafish in vivo. In this study, the igf1-deficient zebrafish model was developed using the CRISPR/Cas9 technique. In this study all the results were performed on both male and female animals. The growth of both male and female igf1-deficient zebrafish were reduced. The igf1 deficiency leads to significant complementary up-regulation of transcriptional expression levels of insulin, igf2 and igf3. This suggested that igf2 and igf3 may act with redundant functions. While the upregulation of gh1 expression can only be detected in igf1-deficient females. At the same time, significant growth retardation, fatty liver, reduced activated levels of ribosomal S6 (S6) are seen only in igf1-deficient males. On the other hand, significant hyperglycemia, elevated transcriptional expression levels of phosphenolpyruvate carboxykinase (pepck) and levels of phosphorylated extracellular signal-regulated kinase (ERK1/2), with additional reduced hepatic lactate/pyruvate (L/P) ratios can only observed in igf1-deficient females. Impaired glucose uptake has been recorded in the primary cultured hepatocytes from igf1-deficient females, but not males. Intriguingly, exposure to 17beta-estroadiol (E2) can partially ameliorated the defects of fatty liver and activation of AKT/mTOR signaling in igf1-deficient males. Our studies demonstrate the significant functions of IGF1 on somatic regulation in zebrafish, with asymmetric gender-related consequences. Our data thus suggest that the zebrafish IGF1 is preferentially required for the activation of AKT/mTOR signaling in male zebrafish, but glucose uptake in females.
Alternation between toxic and proliferative effects of Roundup® on human thyroid cells at different concentrations
Authors: Dal’ Bó Izabela Fernanda , Teixeira Elisângela Souza , Rabi Larissa Teodoro , Peres Karina Colombera , Nascimento Matheus , Chiamolera Maria Izabel , Máximo Valdemar , Bufalo Natássia Elena , Ward Laura Sterian
Published: July 2022

Endocrine-disrupting and carcinogenic effects of glyphosate have long been suspected, but little is known about the effect of compounds used in real life at different concentrations, neither in normal nor in thyroid tumor cells. As cancer cells may have different sensitivities and the effect of the product containing glyphosate may be different from that produced by the active ingredient alone, including the Acceptable Occupational Exposure Level (AOEL=160µg/L) and the Acceptable Daily Intake (ADI=830µg/L) determined by ANVISA, we used two human thyroid-derived cell lines, Nthy-ori 3-1 (from normal follicular cells) and TPC-1 (from papillary carcinoma), to test 15 different concentrations of Roundup® Original DI. Trypan blue (TB), CCK-8 and BrdU assays were used to evaluate cytotoxicity, metabolic activity and proliferation with 24h and 48h exposures in technical and biological triplicates. TB showed an important toxic effect, especially after 24h of exposure, in both cell lines. The AOEL concentration caused the death of 43% and 50% of the Nthy-ori and TPC-1 cells, respectively, in 24 h, while ADI resulted in 35% and 58% of cell death. After 48h of exposure, AOEL and ADI caused a lower number of dead Nthy-ori (33% and 18%) and TPC-1 (33% and 37%) cells, respectively, suggesting that the toxic effect of the product disappears and/or both strains have repair mechanisms that protect them from longer exposures. On the other hand, the CCK-8 assay showed that small concentrations of Roundup have a proliferative effect: 6.5µg/L increased the number of both Nthy-ori and TPC-1 cells at 24h, and the BrdU assay confirmed the stimulatory effect with a 321% increase in the absorbance of Nthy-ori cells at 48h. The herbicide produced even more frequent increases in the BrdU absorbance of TPC-1 cells, mainly at 24h. We conclude that thyroid cells exposed to Roundup present a nonmonotonic dual dose–response curve. Low concentrations of the pesticide, considered acceptable, cause significant cell death but also have an important proliferative effect, especially on TPC-1 cells. This herbicide, widely used around the world, may play a role in the increased incidence rate of thyroid nodules and cancer that has been observed in recent decades.
The correlation between transcription factor 7-like 2 gene polymorphisms and susceptibility of gestational diabetes mellitus in the population of central China: A case–control study
Authors: Zhang Pei , Deng Mengyao , Li Wei , Dai Qiong , He Hua , Zheng Wenpei , She Lu , Xiang Bing , Zeng Jing , Zhou Feng , Guo Yan , Yang Mei
Published: July 2022

Objective

To investigate the correlation between transcription factor 7-like 2 (TCF7L2) gene polymorphisms and gestational diabetes mellitus (GDM) risk in the central Chinese population.

Methods

This case–control study examined the association of seven TCF7L2 gene single-nucleotide polymorphisms (SNPs) (rs11196218, rs4506565, rs7895340, rs7901695, rs11196205, rs12243326, and rs290487) with GDM risk in the central Chinese population (843 GDM and 877 controls). The clinical information and blood samples were collected by trained interviewers and nurses. Genotyping of SNPs was conducted on the Sequenom MassARRAY platform. Statistical analyses including t-test, ANOVA, chi-square test, Fisher’s exact test, and logistic regression were performed.

Results

Differences in age, pre-pregnant body mass index (BMI), and family history of type 2 diabetes mellitus (T2DM) between the case and control groups were significant (p < 0.05). Compared with the wild-type genotype, pregnant women with genotypes of rs4506565-AT (OR = 1.89, 95%CI: 1.18–3.02), rs7895340 GA (OR = 1.93, 95%CI: 1.06–3.54), rs7901695-TC (OR = 1.79, 95%CI: 1.11–2.88), and rs11196205-GC (OR = 2.15, 95%CI: 1.16–3.98) had a significantly higher risk of GDM, adjusted by age, pre-pregnant BMI, and family history of T2DM. Functional annotation showed that all these four SNPs fell in the functional elements of human pancreatic islets. Further cumulative effects analysis concluded that when participants carried all these four risk genotypes, the risk of GDM was 3.51 times (OR = 3.51, 95%CI: 1.38–8.90) than that of those without any risk genotypes.

Conclusions

The findings of this study suggested that rs4506565, rs7895340, rs7901695, and rs11196205 were the genetic susceptibility SNPs of GDM in the central Chinese population. Further studies are needed to validate our findings and clarify the underlying mechanisms.
Interhemispheric Brain Communication and the Evolution of Turn-Taking in Mammals
Authors: Ravignani Andrea , Lumaca Massimo , Kotz Sonja A.
Published: July 2022

In the last 20 years, research on turn-taking and duetting has flourished in at least three, historically separate disciplines: animal behavior, language sciences, and music cognition. While different in scope and methods, all three ultimately share one goal—namely the understanding of timed interactions among conspecifics. In this perspective, we aim at connecting turn-taking and duetting across species from a neural perspective. While we are still far from a defined neuroethology of turn-taking, we argue that the human neuroscience of turn-taking and duetting can inform animal bioacoustics. For this, we focus on a particular concept, interhemispheric connectivity, and its main white-matter substrate, the corpus callosum. We provide an overview of the role of corpus callosum in human neuroscience and interactive music and speech. We hypothesize its mechanistic connection to turn-taking and duetting in our species, and a potential translational link to mammalian research. We conclude by illustrating empirical venues for neuroethological research of turn-taking and duetting in mammals.
NOTCH4 mutation as predictive biomarker for immunotherapy benefits in NRAS wildtype melanoma
Authors: Li Hongxia , Zhang Qin , Duan Qianqian , Tan Yuan , Sun Tingting , Qi Chuang
Published: July 2022

Background

NRAS wildtype melanoma accounts for approximately 80% of melanomas. Previous studies have shown that NRAS wildtype melanoma had higher response rates and better prognoses than NRAS-mutant patients following immunotherapy, while as major actors in tumor cells and tumor microenvironment (TME), the association between NOTCH family genes and response to immunotherapy in NRAS wildtype melanoma remains indistinct.

Objective

We aim to explore whether NOTCH family gene variation is associated with genomic factors in immune checkpoint inhibitor (ICI) response in NRAS wildtype melanoma and with clinical results in these patients.

Method

This research used genomic data of 265 NRAS wildtype ICI-pretreatment samples from five ICI-treated melanoma cohorts to analyze the relationship between NOTCH family gene mutation and the efficacy of ICI therapy.

Results

NRAS wildtype melanomas with NOTCH4-Mut were identified to be associated with prolonged overall survival (OS) in both the discovery (HR: 0.30, 95% CI: 0.11–0.83, P = 0.01) and validation cohorts(HR: 0.21, 95% CI: 0.07–0.68, P = 0.003). Moreover, NOTCH4-Mut melanoma had a superior clinical response in the discovery cohort (ORR, 40.0% vs 13.11%, P = 0.057) and validation cohort (ORR, 68.75% vs 30.07%, P = 0.004). Further exploration found that NOTCH4-Mut tumors had higher tumor mutation burden (TMB) and tumor neoantigen burden (TNB) (P <0.05). NOTCH4-Mut tumors had a significantly increased mutation in the DNA damage response (DDR) pathway. Gene set enrichment analysis revealed NOTCH4-Mut tumor enhanced anti-tumor immunity.

Conclusion

NOTCH4 mutation may promote tumor immunity and serve as a biomarker to predict good immune response in NRAS wildtype melanoma and guide immunotherapeutic responsiveness.
A recombinant murine-like rotavirus with Nano-Luciferase expression reveals tissue tropism, replication dynamics, and virus transmission
Authors: Zhu Yinxing , Sánchez-Tacuba Liliana , Hou Gaopeng , Kawagishi Takahiro , Feng Ningguo , Greenberg Harry B. , Ding Siyuan
Published: July 2022

Rotaviruses (RVs) are one of the main causes of severe gastroenteritis, diarrhea, and death in children and young animals. While suckling mice prove to be highly useful small animal models of RV infection and pathogenesis, direct visualization tools are lacking to track the temporal dynamics of RV replication and transmissibility in vivo. Here, we report the generation of the first recombinant murine-like RV that encodes a Nano-Luciferase reporter (NLuc) using a newly optimized RV reverse genetics system. The NLuc-expressing RV was replication-competent in cell culture and both infectious and virulent in neonatal mice in vivo. Strong luciferase signals were detected in the proximal and distal small intestines, colon, and mesenteric lymph nodes. We showed, via a noninvasive in vivo imaging system, that RV intestinal replication peaked at days 2 to 5 post infection. Moreover, we successfully tracked RV transmission to uninoculated littermates as early as 3 days post infection, 1 day prior to clinically apparent diarrhea and 3 days prior to detectable fecal RV shedding in the uninoculated littermates. We also observed significantly increased viral replication in Stat1 knockout mice that lack the host interferon signaling. Our results suggest that the NLuc murine-like RV represents a non-lethal powerful tool for the studies of tissue tropism and host and viral factors that regulate RV replication and spread, as well as provides a new tool to facilitate the testing of prophylactic and therapeutic interventions in the future.
Influence of single-nucleotide polymorphisms in TLR3 (rs3775291) and TLR9 (rs352139) on the risk of CMV infection in kidney transplant recipients
Authors: Redondo Natalia , Rodríguez-Goncer Isabel , Parra Patricia , Ruiz-Merlo Tamara , López-Medrano Francisco , González Esther , Polanco Natalia , Trujillo Hernando , Hernández Ana , San Juan Rafael , Andrés Amado , Aguado José María , Fernández-Ruiz Mario
Published: July 2022

Risk stratification for cytomegalovirus (CMV) infection after kidney transplantation (KT) remains to be determined. Since endosomal toll-like receptors (TLRs) are involved in viral sensing, we investigated the impact of common single-nucleotide polymorphisms (SNPs) located within TLR3 and TLR9 genes on the occurrence of overall and high-level (≥1,000 IU/ml) CMV infection in a cohort of 197 KT recipients. Homozygous carriers of the minor allele of TLR3 (rs3775291) had higher infection-free survival compared with reference allele carriers (60.0% for TT versus 42.3% for CC/CT genotypes; P-value = 0.050). Decreased infection-free survival was observed with the minor allele of TLR9 (rs352139) (38.2% for TC/CC versus 59.3% for TT genotypes; P-value = 0.004). After multivariable adjustment, the recessive protective effect of the TLR3 (rs3775291) TT genotype was confirmed (adjusted hazard ratio [aHR]: 0.327; 95% CI: 0.167–0.642; P-value = 0.001), as was the dominant risk-conferring effect of TLR9 (rs352139) TC/CC genotypes (aHR: 1.865; 95% CI: 1.170–2.972; P-value = 0.009). Carriers of the TLR9 (rs352139) TC/CC genotypes showed lower CMV-specific interferon-γ-producing CD4+ T-cell counts measured by intracellular cytokine staining compared with the TT genotype (median of 0.2 versus 0.7 cells/μl; P-value = 0.003). In conclusion, TLR3/TLR9 genotyping may inform CMV infection risk after KT.