bluuebunny/crossref_metadata_2025 huggingface dataset:
Circular RNA Expression Profile of Pancreatic Ductal Adenocarcinoma Revealed by Microarray
Authors: Li Haimin , Hao Xiaokun , Wang Huimin , Liu Zhengcai , He Yong , Pu Meng , Zhang Hongtao , Yu Hengchao , Duan Juanli , Qu Shibin
Published: December 2016

Background/Aims: Circular RNAs (circRNAs) are a special novel type of a stable, diverse and conserved noncoding RNA in mammalian cells. Particularly in cancer, circRNAs have been reported to be widely involved in the physiological/pathological process of life. However, it is unclear whether circRNAs are specifically involved in pancreatic ductal adenocarcinoma (PDAC). Methods: We investigated the expression profile of circRNAs in six PDAC cancer samples and paired adjacent normal tissues using microarray. A high-throughput circRNA microarray was used to identify dysregulated circular RNAs in six PDAC patients. Bioinformatic analyses were applied to study these differentially expressed circRNAs. Furthermore, quantitative reverse transcription polymerase chain reaction (qRT-PCR) was performed to confirm these results. Results: We revealed and confirmed that a number of circRNAs were dysregulated, which suggests a potential role in pancreatic cancer. Conclusions: this study demonstrates that clusters of circRNAs are aberrantly expressed in PDAC compared with normal samples and provides new potential targets for the future treatment of PDAC and novel insights into PDAC biology.
Circulating Long Non-Coding RNAs Act as Biomarkers for Predicting 131I Uptake and Mortality in Papillary Thyroid Cancer Patients with Lung Metastases
Authors: Qiu Zhong-Ling , Shen Chen-Tian , Sun Zhen-kui , Wei Wei-Jun , Zhang Xin-Yun , Song Hong-Jun , Luo Quan-Yong
Published: December 2016

Purpose: The aims of the current study were to explore plasma lncRNAs as a novel biomarker panel for the diagnosis of non-131I-avid lung metastases of PTC and to investigate the plasma lncRNA expression levels associated with survival in PTC patients with lung metastases. Methods: The expression of lncRNAs was examined using an lncRNA microarray chip. The lncRNAs with the most significant difference in expression between PTC patients with non-131I-avid lung metastases and PTC patients with 131I-avid lung metastases were verified by quantitative reverse-transcription polymerase chain reaction. The Kaplan-Meier method was used to determine whether the plasma lncRNA levels might be indicative of patient prognosis. Results: Compared with 131I-avid lung metastases, we discovered that two lncRNAs (ENST00000462717 andENST00000415582) were upregulated and two (TCONS_00024700 and NR_028494) were downregulated in the non-131I-avid lung metastases of PTC. Receiver operating characteristic curve (ROC) analyses indicated that the use of these four lncRNAs had high diagnostic sensitivity and specificity for predicting non-131I-avid lung metastases of PTC. The merged areas under the curve for ENST00000462717, ENST00000415582, TCONS_00024700,and NR_028494 in the training and validation sets were 0.890, 0.936, 0.975, and 0.918, respectively. Low (ENST00000462717 and ENST00000415582) and high plasma lncRNA levels(TCONS_00024700and NR_028494) were also found to be associated with better prognosis of PTC patients with lung metastases(P<0.001). Conclusions: ENST00000462717, ENST00000415582, TCONS_00024700, and NR_028494 may be used as novel and minimally invasive markers for the diagnosis and prognostic assessment of non-131I-avid lung metastases from PTC.
Eryptosis as an Underlying Mechanism in Systemic Lupus Erythematosus-Related Anemia
Authors: Jiang Peipei , Bian Maohong , Ma Wenjuan , Liu Chunqiu , Yang Peng , Zhu Bangqiang , Xu Yuanhong , Zheng Meijuan , Qiao Jinpin , Shuai Zongwen , Zhou Xueyong , Huang Dake
Published: December 2016

Background: The progression of systemic lupus erythematosus (SLE) leads to anemia in patients, adversely affecting prognosis. The diverse causes of anemia may include excessive eryptosis or premature suicidal erythrocyte death characterized by cell shrinkage and phosphatidylserine (PS) exposure on the cell surface. The present study explored if SLE enhances eryptosis and the underlying mechanisms. Materials and Methods: Eryptosis was assessed using flow cytometry in healthy volunteers (n = 20) and anemic patients hospitalized for SLE (n = 22), for parameters including PS exposure, cell volume, cytosolic calcium ion (Ca2+) levels and reactive oxygen species (ROS) and ceramide abundance. These indicators were measured in erythrocytes of experimental subjects and erythrocytes treated with plasma from healthy volunteers or SLE patients. Results: The hemoglobin and hematocrit levels were significantly lower in anemic SLE patients than in healthy volunteers (***p<0.001, p<0.001, respectively). The percentage of PS-exposing erythrocytes was significantly higher in SLE patients than in healthy volunteers (p<0.001), accompanied by an increase in cytosolic Ca2+ levels, oxidative stress. The measurements of PS and Ca2+ levels were significantly higher in the erythrocytes of healthy volunteers following incubation in plasma of SLE patients than in plasma of healthy volunteers for 24h (***p<0.001, *p<0.05 respectively). Conclusion: Eryptosis is enhanced in SLE and may contribute to anemia. The probable underlying mechanisms may be an excessive formation of ROS in erythrocytes. Also, some plasma components may trigger eryptosis by increasing the cytosolic Ca2+ concentration.
Bleomycin Suppresses the Proliferation and the Mobility of Human Gastric Cancer Cells Through the Smad Signaling Pathway
Authors: Liu Jin-fang , Nie Xiao-cui , Shao You-cheng , Su Wen-hui , Ma Hai-ying , Xu Xiao-yan
Published: December 2016

Background/Aims: Extensive studies have demonstrated that Bleomycin (BLM) is a glycopeptide antibiotic that has been used as an anticancer chemotherapeutic reagent. It can induce both single- and double-strand DNA damage, inhibit synthesis of DNA, suppress proliferation, and induce apoptosis in cancer cells. Smad signaling transducers are considered as important molecules in tumor development and progression, and may closely be related to the biological behaviors of some malignant carcinomas, including gastric cancer. Methods: The effects of different concentrations of BLM on the proliferation, cell cycle, apoptosis, migration, and invasion on gastric cancer cell lines MKN45 and AGS were assayed by using CCK-8 assay, Annexin V/PI double staining, PI staining, and transwell assay. Western blot and Immunohistochemistry were applied to analyze the potential mechanism(s). Results: BLM treatment resulted in a low proliferation, high apoptosis, low migration and invasion in MKN45 and AGS cells. Furthermore, the possible mechanisms underlying that Smad3 activity could be changed after binding with BLM, and subsequently the Smad signaling pathway had a cascade response. Conclusion: These results highlight BLM as an exciting theme for gastric cancer treatment, which may represent an effective clinical therapeutic reagent for gastric cancer patients.
The Role of TLR4 in M1 Macrophage-Induced Epithelial-Mesenchymal Transition of Peritoneal Mesothelial Cells
Authors: Shi Jun , Li Qing , Sheng Meixiao , Zheng Min , Yu Manshu , Zhang Lu
Published: December 2016

Background/Aims: Peritoneal fibrosis is a frequent complication of peritoneal dialysis that follows inflammation. It is recognized that epithelial-mesenchymal transition (EMT) of peritoneal mesothelial cells (PMCs), plays a key role in fibrogenesis. However, the relationship between inflammatory macrophages and PMCs remains elusive. In this study, we investigated the effects of different polarized macrophages on EMT of HMrSV5 PMCs. Methods: Monocytes were polarized to M1/M2 macrophages before being added to HMrSV5 in direct or indirect contact. Morphological changes of HMrSV5 were observed and toll-like receptors 4 (TLR4) on macrophage surfaces was detected using flow cytometry. EMT markers and intracellular signals of HMrSV5 cells were assessed using real time-PCR and WB. Results: The typical epithelial cell morphology of HMrSV5 disappeared after co-culture with M1 macrophages and was accompanied by decreased E-cadherin and increased α-SMA, suggesting HMrSV5 undergo EMT. These effects depended on direct contact between the two cells, as indirect contact or co-culture with M2 macrophages had no effect. Intriguingly, we found TLR4 surface receptors were activated on sorted M1 cells in co-culture, and related signal adaptors, such as TRIF, were obviously upregulated. Conclusion: Direct contact with M1 macrophages induces EMT of PMCs, during which TRIF-dependent TLR4 signaling pathway was activated.
Acupuncture Versus Non-Steroidal Anti-Inflammatory Drugs for Treatment of Chondromalacia Patellae: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Lv Zheng-Tao , Li Zhi-Qiang , Zhou Xiang , Ma Wen-Wen , Zhang Jin-Ming , Chen An-Min
Published: December 2016

This systematic review aims to evaluate the efficacy and safety of acupuncture therapy for treating patients with chondromalacia patellae compared to non-steroidal anti-inflammatory drugs (NSAID). Eight databases including PubMed, EMBASE, CENTRAL, ISI Web of Science, CNKI, Wanfang, VIP, and CBM were searched up to June 2016. Randomized controlled trials (RCT) assessing the efficacy of acupuncture therapy were identified. The patients in experimental groups had to be treated with acupuncture therapy, and the patients in control groups had to be treated with NSAID. The outcome measures included clinical efficacy rates or pain scores. A total of 7 studies met our inclusion criteria. We analyzed the data from these 7 RCT involving 707 participants. All included studies were judged to be at high risk for bias. Compared with NSAID, acupuncture could further improve the clinical efficacy rates (Risk Ratio 2.57; 95% confidence interval (CI) 2.02, 3.27) and pain scores (Mean Difference -1.49; 95% CI -2.37, -0.62). No study reported adverse events associated with acupuncture therapy. Based on the findings in the present review, acupuncture therapy is more effective than NSAID in improving clinical efficacy rates and pain scores. However, these results should be interpreted cautiously due to the poor overall methodological quality of the included trials. Additional studies with large-scale and rigorous experimental design are required.
The Impact of Diabetes Mellitus on Patients Undergoing Cervical Spondylotic Myelopathy: A Meta-Analysis
Authors: Liu Yang , Ban De-xiang , Kan Shi-lian , Cao Tai-wei , Feng Shi-qing
Published: December 2016

Aims: We conducted a meta-analysis of eligible studies to compare the surgical outcomes between diabetic patients and non-diabetic patients who have undergone cervical spondylotic myelopathy (CSM). Methods: A systematic literature search of PubMed, Embase, and Web of Science (up to February 10, 2016) was conducted. Eligible studies were case-control or cohort studies that compared the outcomes of cervical surgery between diabetic patients and non-diabetic patients. Weighted mean differences, risk ratios, and 95% CIs were calculated and heterogeneity was assessed with Cochrane Q chi-square test and I2 statistic. Results: Six studies with a total of 38,680 patients were included in this meta-analysis. Pooled estimates showed that diabetic patients had significantly lower Japanese Orthopaedic Association (JOA) score change between pre- and post operation, and recovery rate than patients without diabetes. Moreover, diabetic patients had significantly increased risk of operative wound, epidural/wound hematoma, chronic lung disease, and cardiac complication. Other postoperative complications, including cerebrospinal fluid leakage and C5 radiculopathy, were not significantly different between the 2 groups. Conclusion: Diabetes mellitus decreased the JOA score change and recovery rate, as well as increased the risk of postoperative complications in patients undergoing CSM. Controlling diabetes mellitus before cervical spine surgery may lead to better outcomes.
José Medina Echavarría: una mirada sobre América Latina desde la sociología económica y la teoría 1952-1977
Authors: Moya Lopez Laura
Published: December 2016

José Medina Echavarría é um dos sociólogos mais importantes da América Latina no século xx. Reconhecido como um dos principais intelectuais do exílio espanhol de 1939, suas contribuições à institucionalização das ciências sociais foram decisivas no Colégio do México, na Flacso e naCepal. Neste artigo, apresento um panorama geral do pensamento sociológico de Medina, sua profunda preocupação sobre a crise da modernidade, assim como suas ideias sobre o novo papel das ciências sociais na América Latina. Foi membro da Cepal durante 25 anos (1952-1977), período no qual se pode notar uma clara transição entre suas ideias sobre a teoria e os conceitos sociológicos e o balanço crítico sobre os efeitos das políticas econômicas e sociais para os países em via de desenvolvimento. Tais ideias tem como base a sua análise da sociologia econômica de Max Weber.
Três décadas após o Ateneo de la Juventud. José Vasconcelos, Antônio Caso e a democracia liberal
Authors: Hernandez Prado José
Published: December 2016

Em 1910, um dos filósofos do mexicano Ateneu da Juventude (1909-1912), José Vasconcelos (1882-1959), aderiu à campanha presidencial de Francisco I. Madero, enquanto que outro, Antonio Caso (1883-1946), apoiava a sétima reeleição de Porfirio Díaz. Trinta anos depois, em 1940 e no contexto internacional da Segunda Guerra Mundial, um dos antigos ateneístasapoiava a Alemanha nazista, enquanto o outro tomava partido pelas democracias ocidentais, especificamente a britânica. No entanto, agora Vasconcelos era o primeiro e Antonio Caso, o segundo. Os papéis foram totalmente trocados.
Apresentação
Authors: Jackson Luiz Carlos , Blanco Alejandro Raúl
Published: December 2016

O texto faz uma apresentação do dossiê "Sociologia, cultura e política no México".
Veredas da mudança na ciência brasileira
Authors: Klein Stefan , Toledo Ferreira Mariana
Published: December 2016

Review of: Maria Caramez Carlotto, Veredas da mudança na ciência brasileira: discurso, institucionalização e práticas no cenário contemporâneo. São Paulo, Scientiae Studia/34, 2013. 379 pp.
Effects of entry of Venezuela in MERCOSUR: The creation and trade diversion in Brazil
Authors: Silva Carla Calixto da , Hidalgo Álvaro Barrantes
Published: December 2016

O objetivo deste artigo é mensurar os prováveis impactos estáticos do processo de integração por meio da criação e do desvio de comércio entre o Brasil e a Venezuela, com a entrada efetiva, ex-ante, desse país no MERCOSUL. Para tanto, o artigo faz uso do modelo de equilíbrio parcial das elasticidades de Laird & Yeats (1986), utilizando os setores exportadores a 2 dígitos (00 a 99) do SITC Rev. 3. O resultado das simulações para o período 1995-2011 parece mostrar que a entrada da Venezuela no MERCOSUL, com a eliminação de barreiras comerciais, traria impacto relevante sobre as exportações brasileiras. Para quase todos os setores estudados, o efeito criação de comércio mostra-se superior ao efeito desvio de comércio, evidenciando a competitividade das exportações brasileiras no mercado da Venezuela
The Microstructure of Tesouro Direto: The Sazonality of the Order Flow and the Formation of Spreads
Authors: Perlin Marcelo
Published: December 2016

O objetivo deste artigo é analisar a microestrutura do Tesouro Direto em dois pontos: a dinâmica do fluxo de ordens e o processo de formação dos spreads. A análise dos dados mostra uma forte sazonalidade no fluxo de ordens deste mercado. Esta previsibilidade pode auxiliar na administração do estoque de títulos por parte do governo. O segundo ponto de análise no estudo foi na formação do spread no tesouro direto. No desenvolvimento do artigo se discute os fatores negativos a respeito do método utilizado atualmente e apresenta-se uma alternativa mais parcimoniosa através de um modelo de ajustamento
Pneumocistose diagnosticada durante a gestação: relato de caso
Authors: Coelho Junior Luilson Geraldo , Souza Daniel Lima , Machado Gabrielly Borges , Silva Juliana Siqueira , Monteiro Maria Luíza Gonçalves dos Reis
Published: December 2016

A infecção pelo vírus da imunodeficiência humana (HIV) cursa com um amplo espectro de apresentações clínicas, desde a fase aguda até a fase avançada da doença. Em indivíduos não tratados o tempo médio entre o contágio com o vírus e o surgimento da doença ocorre em torno de dez anos. O aparecimento de infecções oportunistas e neoplasias é definidor da Síndrome da Imunodeficiência Adquirida, sendo que nessas situações a contagem de linfócitos TCD4+ está abaixo de 200 células/mm³. A pneumocistose, uma pneumonia fúngica, é causada pelo fungo Pneumocystis jirovecii. É considerada doença definidora da síndrome da imunodeficiência adquirida (SIDA), possui alta morbimortalidade, curso clínico grave; sendo uma causa comum de doença pulmonar oportunista em imunodeprimidos. Há poucos relatos de pneumocistose em pacientes gestantes infectadas pelo vírus da imunodeficiência humana (HIV), sendo que nesta parcela de pacientes, a pneumocistose é considerada uma doença rara. Descrevemos um caso em que a paciente não realizou Pré-Natal durante a gestação, apresentando como primeira manifestação clínica do HIV/SIDA, a pneumocistose.
Diversidade de uma cultura urbanística nacional
Authors: Fernandes Luiz Gustavo Sobral
Published: December 2016

TAVARES, Jeferson. Projetos para Brasília 1927-1957. Brasília: Iphan, 2014.
A engenharia sanitária a serviço do urbanismo: a contribuição de Saturnino de Brito e Victor da Silva Freire para a construção dos saberes urbanos
Authors: Bertoni Angelo
Published: December 2016

Este trabalho analisa duas figuras de primeiro plano do urbanismo brasileiro da virada do século XX: os engenheiros Saturnino de Brito e Victor da Silva Freire. Eles contribuíram com seus pensamentos e atividades para a introdução e adaptação no Brasil de conceitos urbanísticos então debatidos na Europa e nos Estados Unidos. Seus textos da década de 1910 permitem uma atualização sobre o diálogo transnacional existente na época entre os especialistas em questões urbanas: referências, citações e algumas omissões contidas em seus escritos ajudam a reconstruir uma parte importante da história do urbanismo no Brasil, como conhecimento e savoir-faire.
O urbanismo de Saturnino de Brito e as ressonâncias provocadas
Authors: Tochetto Daniel , Ferraz Célia
Published: December 2016

Na elaboração de projetos de saneamento para as cidades brasileiras, o engenheiro Francisco Saturnino Rodrigues de Brito defendeu a necessidade de desenvolver conjuntamente aspectos pertinentes ao campo do urbanismo. O entendimento de Brito sobre como pensar a cidade foi detalhado e desenvolvido na época em que trabalhou para a Comissão de Saneamento de São Paulo, no contexto de sua Usina de Santos em 1905-10, e Notas sobre a traça sanitária das Vilas (1916). A análise dessas duas obras, juntamente com a discussão e os problemas que ocorreram em Santos, constituem o objetivo central deste trabalho.
Atividades em Comunicação & Educação – Ano XXI – n. 2
Authors: Itacarambi Ruth Ribas
Published: December 2016

Atividades em sala de aula.
Política pública: a televisão infantil na educação infantil
Authors: Fuenzalida Valerio
Published: December 2016

Desde meados da década de 1990 têm aparecido novos programas infantis de televisão que mostram novas representações do público infantil. A neurobiologia cerebral e as teorias epigenéticas do desenvolvimento infantil descobriram a imagem de uma criança com capacidades e motivações internas por desenvolver. Está se evoluindo para uma nova representação televisiva do público infantil e para um construtivismo cultural na recepção. Esses programas representam uma criança com competências socioemocionais. Essa representação infantil é mais complexa e convoca uma audiência construtivista dos programas. É necessário desenvolver uma política pública de introdução sistemática na educação infantil de tais programas de televisão com valor socioemocional de formação.
Educomunicação e Mediação Escolar: Um projeto educomunicativo para a relação Criança, Desenho Animado e Consumo
Authors: Penteado Brandão Prado Ana Lucia , Mungioli Maria Cristina
Published: December 2016

O presente artigo aborda a relação entre infância e consumo a partir de seu estímulo pelas mídias contemporâneas. Partindo de uma concepção educomunicativa, defende-se que a partir da Educação para a Comunicação e da mediação escolar, o desenho animado pode ser empregado como ferramenta para educar criticamente as crianças, visando a sua formação como sujeitos ativos no processo comunicativo. Finalizamos o estudo com uma proposta de intervenção educomunicativa por meio da qual se preconiza na educação infantil a realização de atividades com desenho animado e suas personagens como meio de educar as crianças para as mídias e possíveis influências em relação ao consumo.
O tempo e o mundo: defesa de uma história planetária
Authors: Velloso Gustavo
Published: December 2016

Resenha do livro: GRUZINSKI, Serge. As quatro partes do mundo: história de uma mundialização. Tradução de Cleonice Paes Barreto Mourão e Consuelo Fortes Santiago. Belo Horizonte: Editora UFMG; São Paulo: Edusp, 2014.
Depois da batalha de Pungo Andongo (1671): o destino atlântico dos príncipes do Ndongo
Authors: Lara Silvia Hunold
Published: December 2016

Em dezembro de 1671, depois de um cerco de vários meses, as tropas comandadas por Luís Lopes de Sequeira conseguiram tomar a capital do Reino do Ndongo. O rei foi morto e houve muitos prisioneiros, entre eles parentes do soberano, que foram deportados para o Brasil e depois para Portugal. O artigo procura reconstituir o périplo dos príncipes do Ndongo no exílio, discutindo seus significados tendo em vista o contexto do avanço colonial pelos sertões de Angola, os dilemas das autoridades na América portuguesa e as políticas metropolitanas em relação aos africanos em Portugal. Cruzando processos que se desenvolveram em Angola, no Brasil e em Portugal, procura-se compreender os motivos pelos quais os herdeiros do Reino do Ndongo não foram escravizados, como a maioria dos prisioneiros feitos naquela batalha.
Carlos III y el Estado fiscal-militar 1779-1783
Authors: Serrano Álvarez José Manuel
Published: December 2016

Resenha do livro: TORRES SÁNCHEZ, Rafael. El precio de la guerra. El Estado fiscal-militar de Carlos III (1779-1783). Madrid: Marcial Pons, 2013, 459 p.
Velimír Khlébnikov: para além da poesia
Authors: Francisco Junior Mario Ramos
Published: December 2016

A partir de observações sobre aspectos formais, temáticos e filosóficos característicos da poética de Velimír Khlébnikov, e da inserção de sua criação no contexto das vanguardas russas do início do século XX, este artigo tem como objetivo apresentar e abordar exemplos de sua produção em prosa, texto dramático e ensaio. Khlébnikov é bastante conhecido no Ocidente por sua produção lírica e seu trabalho com outros gêneros ainda é pouco estudado e traduzido em língua portuguesa
O anjinho
Authors: Andrêiev Leonid , Salvador Helena Kardash
Published: December 2016

Leonid Andrêiev foi um dos mais populares e polêmicos escritores russos da primeira década do século XX. A diversidade de estilos tão peculiar em seus contos, novelas e peças faz com que o escritor seja considerado uma figura solitária no contexto histórico-literário, difícil de ser atrelada a qualquer movimento específico, mas que representa um momento de transição pelo qual passou a literatura russa. Entre os contos de seu primeiro livro, publicado em 1901, está O anjinho, que apresenta um episódio na vida de Sachka, um menino pobre expulso da escola por mau comportamento, mas que ainda assim é convidado para a festa de Natal de seus benfeitores. A princípio uma narrativa realista convencional, o conto sutilmente vai tocando as fronteiras do simbolismo, onde o real e o ideal conduzem ao retrato da condição humana que se delineia por toda a obra de Andrêiev.
Stanislávski: um iluminista no coração de outubro
Authors: Moschkovich Diego
Published: December 2016

Konstantin Serguéievitch Stanis-lávski (1863 – 1938) é considerado o mais importante diretor de teatro da Rússia no século XX, assim como um dos mais importantes do mundo. Nascido em Moscou apenas dois anos após a libertação dos servos da gleba (1861), Stanislávski tornou-se, durante o século XX, o modelo e o inspirador das artes cênicas russas, tendo sido inclusive seu Sistema de interpre-tação considerado como o Sistema padrão de todas as escolas de formação teatral na URSS. Filho de uma das famílias industriais mais abas-tadas do Império Russo, Stanislávski dedica sua vida ao teatro e, paradoxalmente, termina como símbolo máximo do teatro de um país auto-in-titulado como “ditadura do proletariado”. Tendo em vista a frutífera vida teatral de Stanislávski, o volume e a importância real de suas pes-quisas para o desenvolvimento da arte cênica contemporânea, este artigo busca investigar a relação direta entre Konstantin Stanislávski e os primeiros anos da Revolução de Outubro (1917 – 1920), para tentar compreender parte do processo de reconhecimento de Stanislávs-ki pelo Poder Soviético, apesar de sua origem burguesa.
Resenha de Arte e técnica em Heidegger, de Irene Borges-Duarte
Authors: Pasqualin Chiara
Published: December 2016

Resenha de Arte e técnica em Heidegger, de Irene Borges-Duarte (Lisboa: Documenta, 2014)
A Estrutura Filológica da Tragédia Grega: a propósito da “Introdução à tragédia de Sófocles” de Nietzsche
Authors: Souza Ronaldo Tadeu de
Published: December 2016

Resenha de Introdução à Tragédia de Sófocles, de Friedrich Nietzsche, tradução de Marcos Sinésio Pereira Fernandes (São Paulo: Martins Fontes, 2014)
Los elementos filosóficos de El Estado comercial cerrado de Fichte
Authors: Gaudio Mariano Lucas
Published: December 2016

En el presente trabajo se intenta mostrar el trasfondo filosófico del concepto de Estado racional en El Estado comercial cerrado (1800) de Fichte, en cuanto los problemas políticos y económicos se sustentan en la concepción metafísica de la Doctrina de la Ciencia. Y se analizan tres ejes: en primer lugar, lo ideal como fundamento de lo real, donde éste se explica desde un concepto de fin proyectado; luego, la doble contraposición frente al dogmatismo y la articulación entre lo universal y lo particular en el idealismo, que conduce a una visión del Estado como unidad fundante; y finalmente, el espacio comercial social - horizontal, donde la posición de cada particular está en relación recíproca con cada otro particular.
Carnap, Wittgenstein e o problema da metafísica
Authors: Segatto Antonio Ianni
Published: December 2016

O artigo pretende, em primeiro lugar, caracterizar o programa de superação da metafísica proposto por Rudolf Carnap no artigo “Superação da metafísica pela análise lógica da linguagem” e apresentar um paralelo entre suas conclusões e aquelas apresentadas por Moritz Schlick em textos anteriores. Em segundo lugar, pretende-se mostrar que a filiação de Carnap ao Tractatus logico-philosophicus de Wittgenstein está baseada em uma compreensão sui generis da noção mesma de contrassenso e da tese de que as supostas proposições da metafísica são destituídas de sentido. Essa compreensão, porém, se baseia na apropriação do verificacionismo que o próprio Wittgenstein propôs no início da década de 1930.
Superação da metafísica pela análise lógica da linguagem
Authors: Carnap Rudolf
Published: December 2016

Publicado originalmente em Erkenntnis, 2. Band, 1931, pp. 219-241. Publicado com a permissão da Oxford University Press.
Poder, violência e revolução no pensamento político de Hannah Arendt
Authors: Duarte André
Published: December 2016

Discuto as distinções arendtianas entre poder e violência, referindo-as à sua análise das modernas revoluções. Após retraçar aquela distinção, discuto o seu caráter relacional e contesto as críticas que asseveram seu caráter supostamente rígido e essencialista. Ao enfatizar seu caráter relacional, argumento que tais distinções nos permitem compreender a natureza de fenômenos distintos em suas intrínsecas relações, de modo que não se poderia pensar a política sem a violência ou o público sem o privado. Finalmente, argumento que o legado de sua análise das revoluções reside em sugestões para revitalizar o exercício da democracia no presente.
A questão da paisagem no Brasil através de Roberto Burle Marx
Authors: Leister Alexandra Maria Aguiar
Published: December 2016

No Brasil, as paisagens de Burle Marx enriquecem o pensamento sobre a paisagem, emprestado, com frequência, de autores internacionais. Este artigo, debruçando-se no referencial teórico dos campos da filosofia e da geografia, conduziu uma reflexão em torno da paisagem com base nas obras do mestre brasileiro Roberto Burle Marx. Sua caminhada profissional revela uma contribuição singular no aprofundamento da questão da paisagem. Como uma díade, sua concepção teórica da natureza transformava-se em paisagens vivenciáveis. Nesse processo etéreo, construiu lugares dignos de despertar olhares sensíveis. Este artigo reflete os conceitos teóricos de Burle Marx sobre a paisagem, sua maneira de transformá-los em projetos paisagísticos e suas considerações em relação ao futuro da paisagem brasileira.
Sistema de espaços livres e espacialidades da esfera pública em favela: os casos de Paraisópolis, da Linha e do Nove em São Paulo
Authors: Pizarro Eduardo Pimentel
Published: December 2016

As favelas são realidades consolidadas na cidade de São Paulo, concentrando mais de 10% de sua população, e o Sistema de Espaços Livres da cidade dita informal constitui grande potencial de investigação no que diz respeito a suas características físicas, à articulação entre espaços públicos e privados e, principalmente, às práticas públicas e cotidianas nele desenvolvidas. No presente artigo, são selecionadas, como estudos de caso, três favelas da cidade de São Paulo: a favela de Paraisópolis – segunda maior comunidade do município, localizada em meio ao “Morumbi”, com cerca de 100 mil habitantes em 100 hectares de área –, as favelas da Linha e do Nove, que juntas ocupam menos de 2 hectares no entorno da Companhia de Entrepostos e Armazéns Gerais de São Paulo (Ceagesp) e concentram 630 famílias. Baseado em visitas de campo, este artigo mostra quais as dinâmicas espaciais e públicas que regem esses espaços e que poderiam servir à discussão do Sistema de Espaços Livres da cidade.
Organizações Dierberger (1893-1940)
Authors: Enokibara Marta
Published: December 2016

O objetivo deste artigo é traçar um percurso cronológico sobre as Organizações Dierberger – o conjunto de estabelecimentos comerciais, empresas e campos de cultura fundado pelo alemão Johann Dierberger (1859-1931) e seus filhos – a partir do material levantado e catalogado no arquivo da família. Esse percurso tem início com a primeira firma, o Estabelecimento Floricultura, fundado em 1893 por Dierberger, e termina em 1940 quando seus filhos passam a conduzir firmas especializadas.
A interface entre pesquisa e extensão na discussão dos parques lineares como estratégia de requalificação da paisagem urbana
Authors: Pereira Renata Baesso , Ribeiro Claudia Maria Lima , Bueno Adriano , Ribeiro Daniel Henrique , Maia Danilo Pena , Martini Fernanda , Angote Maria Stella , Lazarin Ricardo , Roda Rodrigo , Bartolo Viviane Bestane
Published: December 2016

Este artigo discute as práticas acadêmicas do grupo Programa de Ensino Tutorial no curso de Arquitetura e Urbanismo da Pontifícia Universidade Católica de Campinas relatando as experiências de um convênio firmado entre a Universidade e a Prefeitura Municipal de Campinas (SP) na elaboração do projeto de um parque linear. Busca-se refletir sobre o potencial de convênios como esse na elaboração de práticas de pesquisa e ensino de projeto que contemplam as diversas instâncias do urbanismo na escala do município. Identificou-se uma oportunidade de refletir criticamente sobre a criação de um parque linear como estratégia de requalificação da paisagem urbana, contribuindo para a estruturação do sistema de espaços livres da cidade de Campinas.
Uric Acid Is Associated With Inflammation, Coronary Microvascular Dysfunction, and Adverse Outcomes in Postmenopausal Women
Authors: Prasad Megha , Matteson Eric L. , Herrmann Joerg , Gulati Rajiv , Rihal Charanjit S. , Lerman Lilach O. , Lerman Amir
Published: December 2016

Uric acid is a risk factor for coronary artery disease in postmenopausal women, but the association with inflammation and coronary endothelial dysfunction (CED) is not well defined. The aim of this study was to determine the relationship of serum uric acid (SUA), inflammatory markers, and CED. In this prospective cohort study, SUA, high-sensitivity C-reactive protein levels, and neutrophil count were measured in 229 postmenopausal women who underwent diagnostic catheterization, were found to have no obstructive coronary artery disease, and underwent coronary microvascular function testing, to measure coronary blood flow response to intracoronary acetylcholine. The average age was 58 years (interquartile range, 52–66 years). Hypertension was present in 48%, type 2 diabetes mellitus in 5.6%, and hyperlipidemia in 61.8%. CED was diagnosed in 59% of postmenopausal women. Mean uric acid level was 4.7±1.3 mg/dL. Postmenopausal women with CED had significantly higher SUA compared with patients without CED (4.9±1.3 versus 4.4±1.3 mg/dL;
P
=0.02). There was a significant correlation between SUA and percent change in coronary blood flow to acetylcholine (
P
=0.009), and this correlation persisted in multivariable analysis. SUA levels were significantly associated with increased neutrophil count (
P
=0.02) and high-sensitivity C-reactive protein levels (
P
=0.006) among patients with CED, but not among those without CED. SUA is associated with CED in postmenopausal women and may be related to inflammation. These findings link SUA levels to early coronary atherosclerosis in postmenopausal women.
“Why Should I Question a Patient’s Wish?”A Comparative Study on Physicians’ Perspectives on Their Duties to Respect Advance Directives
Authors: Horn Ruth
Published: December 2016

This article explores factors that impede the implementation of advance directives to refuse treatment (ads) in three European countries: England, Germany and France. Taking into account socio-cultural and legal aspects, the article shows the extent, to which the law can, and does, influence physicians’ decisions to implement ads. The findings presented are based on qualitative interviews exploring physicians’ sense of duty to respect ads and the reasons given for failing to implement the law. It will be argued that this depends on: 1) how strictly the legal status of ads is defined, and 2) whether the law actually addresses the reasons why physicians may hesitate to implement ads (e.g. uncertainty about validity, importance of patient preferences). The article emphasises the importance of doctor-patient communication and shows how the implementation of ads could be improved by making discussions about treatment preferences a legal requirement.
Törü: Ancient Turkic Law ‘Privatised’ by Chinggis Khan and His Descendants
Authors: Pochekaev Roman Yu.
Published: December 2016

This article is devoted to törü—law of the ancient Turks, which later became one of the sources of medieval Mongol law and, eventually, integral to the legal system of the Mongol Empire ruled by Chinggis Khan and his descendants. The post-imperial Chinggisids used törü as a means to reinforce their legitimacy among their Turkic subjects as a ‘privatised’ right to interpret and even create törü regulations. At the same time their Mongolian neighbours used törü mostly as a political (rather than legal) category and did not obtain a monopoly for it, as törü in Mongolia was interpreted as an attribute of supreme power, even when it spread beyond the descendants of Chinggis Khan.
Diabetes self-management education after pre-selection of patients: design of a randomised controlled trial
Authors: Vos Rimke C. , Eikelenboom Nathalie W. D. , Klomp Maarten , Stellato Rebecca K. , Rutten Guy E. H. M.
Published: December 2016

Background

Many self-management programs have been developed so far. Their effectiveness varies. The program ‘Beyond Good Intentions’ (BGI) is based on proactive coping and has proven to be (cost-) effective in achieving reductions in BMI and blood pressure in screen-detected type 2 diabetes patients up until nine months follow-up. However, its long-term effectiveness in people already known with diabetes is lacking. In addition, its (cost-) effectiveness might increase if people who are likely not to be benefit from the program are excluded in a valid way. Therefore it was aimed to investigate the long-term effects of the educational program BGI on cardiovascular risk, quality of life and diabetes self-management behaviour in a pre-selected group of patients known with type 2 diabetes up to 5 years.

Methods

Randomised controlled trial with 2.5 year follow-up. Adults (≤75 years) with a type 2 diabetes duration between 3 months and 5 years will be included. With the use of a self-management screening tool (SeMaS) their potential barriers of self-management due to depression and/or anxiety will be determined. Based on the results of the SeMaS selection patients will be randomised (1:1) to the BGI-group (n = 53) or the control-group (n = 53). In addition to receiving usual care, patients in the BGI-group will follow the 12-week theory-based self-management program and a booster session a few months thereafter. The control-group will receive care as usual. The primary outcome is change in Body Mass Index after 2.5 years follow-up. Secondary outcomes are HbA1c, lipid profile and systolic blood pressure, (diabetes) quality of life, level of physical activity, dietary intake and medication adherence and proactive coping. Cost-effectiveness will be based on total use of health care resources during the entire study period. Difference between groups in change over time will be analysed according to intention-to-treat analysis.

Conclusions

By differentiating between patients who will and those who are likely not to benefit from the educational program, a more (cost-) effective self-management program might be designed, also on the long-run.

Trial registrationNTR 5330
Complete genome sequence of the actinomycete Actinoalloteichus hymeniacidonis type strain HPA 177T isolated from a marine sponge
Authors: Schaffert Lena , Albersmeier Andreas , Winkler Anika , Kalinowski Jörn , Zotchev Sergey B. , Rückert Christian
Published: December 2016

Actinoalloteichus hymeniacidonis HPA 177T is a Gram-positive, strictly aerobic, black pigment producing and spore-forming actinomycete, which forms branching vegetative hyphae and was isolated from the marine sponge Hymeniacidon perlevis.

Actinomycete bacteria are prolific producers of secondary metabolites, some of which have been developed into anti-microbial, anti-tumor and immunosuppressive drugs currently used in human therapy. Considering this and the growing interest in natural products as sources of new drugs, actinomycete bacteria from the hitherto poorly explored marine environments may represent promising sources for drug discovery.

As A. hymeniacidonis, isolated from the marine sponge, is a type strain of the recently described and rare genus Actinoalloteichus, knowledge of the complete genome sequence enables genome analyses to identify genetic loci for novel bioactive compounds. This project, describing the 6.31 Mbp long chromosome, with its 5346 protein-coding and 73 RNA genes, will aid the Genomic Encyclopedia of Bacteria and Archaea project.
Locally solving fractional Laplacian viscoacoustic wave equation using Hermite distributed approximating functional method
Authors: Yao Jie , Zhu Tieyuan , Hussain Fazle , Kouri Donald J.
Published: December 2016

Accurate seismic modeling in realistic media serves as the basis of seismic full-waveform inversion and imaging. Recently, viscoacoustic seismic modeling incorporating attenuation effects has been performed by solving a fractional Laplacian viscoacoustic wave equation. In this equation, attenuation, being spatially heterogeneous, is represented partially by the spatially varying power of the fractional Laplacian operator previously approximated by the global Fourier method. We have developed a local-spectral approach, based on the Hermite distributed approximating functional (HDAF) method, to implement the fractional Laplacian in the viscoacoustic wave equation. Our approach combines local methods’ simplicity and global methods’ accuracy. Several numerical examples are developed to evaluate the feasibility and accuracy of using the HDAF method for the frequency-independent [Formula: see text] fractional Laplacian wave equation.
CenpH regulates meiotic G2/M transition by modulating the APC/CCdh1-cyclin B1 pathway in oocytes
Authors: Zhang Teng , Zhou Yang , Li Li , Wang Zhen-Bo , Shen Wei , Schatten Heide , Sun Qing-Yuan
Published: December 2016

Meiotic resumption (G2/M transition) and progression through meiosis I (MI) are two critical stages for producing fertilization-competent eggs. Here, we report that CenpH, a component of the kinetochore inner plate protein, is responsible for the G2/M transition in meiotic mouse oocytes. Depletion of CenpH using morpholino injection decreased cyclin B1 levels, resulting in an attenuation of MPF activation, and severely compromised the meiotic resumption. CenpH protects cyclin B1 from destruction by competing actions of APC/CCdh1. Impaired G2/M transition after CenpH depletion could be rescued by expression of exogenous cyclin B1. Unexpectedly, blocking of CenpH did not affect spindle organization and meiotic cell cycle progression after germinal vesicle breakdown. Our findings reveal a novel role of CenpH in regulating meiotic G2/M transition by acting via the APC/CCdh1-cyclin B1 pathway.
A MAPK cascade couples maternal mRNA translation and degradation to meiotic cell cycle progression in mouse oocytes
Authors: Sha Qian-Qian , Dai Xing-Xing , Dang Yujiao , Tang Fuchou , Liu Junping , Zhang Yin-Li , Fan Heng-Yu
Published: December 2016

Mammalian oocyte maturation depends on the translational activation of stored maternal mRNAs upon meiotic resumption. Cytoplasmic polyadenylation element binding protein 1 (CPEB1) is a key oocyte factor that regulates maternal mRNA translation. However, the signal that triggers CPEB1 activation at the onset of mammalian oocyte maturation is not known. We provide evidence that a mitogen-activated protein kinase (MAPK) cascade couples maternal mRNA translation to meiotic cell cycle progression in mouse oocytes by triggering CPEB1 phosphorylation and degradation. Mutations of the phosphorylation sites or ubiquitin E3 ligase binding sites in CPEB1 have a dominant-negative effect in oocytes, and mimic the phenotype of ERK1/2 knockout, by impairing spindle assembly and mRNA translation. Overexpression of the CPEB1 downstream translation activator DAZL in ERK1/2-deficient oocytes partially rescued the meiotic defects, indicating that ERK1/2 is essential for spindle assembly, metaphase II arrest and maternal-zygotic transition (MZT) primarily by triggering the translation of key maternal mRNAs. Taken together, ERK1/2-mediated CPEB1 phosphorylation/degradation is a major mechanism of maternal mRNA translational activation, and is crucial for mouse oocyte maturation and MZT.
Male bumblebees perform learning flights on leaving a flower but not when leaving their nest
Authors: Robert Théo , Frasnelli Elisa , Collett Thomas S. , de Ibarra Natalie Hempel
Published: December 2016

Female bees and wasps demonstrate, through their performance of elaborate learning flights, when they memorise features of a significant site. An important feature of these flights is that the insects look back to fixate the site that they are leaving. Females, which forage for nectar and pollen and return with it to the nest, execute learning flights on their initial departures from both their nest and newly discovered flowers. To our knowledge, these flights have so far only been studied in females. Here we describe and analyse putative learning flights observed in male bumblebees, Bombus terrestris L. Once male bumblebees are mature, they leave their nest for good and fend for themselves. We show that, unlike female foragers, males always flew directly away from their nest, without looking back, in keeping with their indifference to their natal nest. In contrast, after males had drunk from artificial flowers, their flights on first leaving the flowers resembled the learning flights of females, particularly in their fixations of the flowers. These differences in the occurrence of female and male learning flights seem to match the diverse needs of the two sexes to learn about ecologically relevant aspects of their environment.
Physiological factors affecting performance in elite distance runners
Authors: Tjelta Leif Inge , Shalfawi Shaher A. I.
Published: December 2016

Running distances from 3000 m to the marathon (42 195 m) are events dominated by energy contribution of the aerobic energy system. The physiological factors that underlie success in these running events are maximal oxygen uptake (VO2max), running economy (RE), the utilization of the maximum oxygen uptake (%VO2max) and velocity at the anaerobic threshold (vAT). VO2max for distance runners competing on an international level has been between 70 and 87 ml/kg/min in men, and between 60 and 78.7 ml/kg/min in women, respectively. Due to lack of air resistance, laboratory testing of RE and vAT are recommended to be conducted on treadmill with 1% slope. %VO2max are in most studies expressed as the average fractional utilization of VO2max at vAT. Much of the current understanding regarding the response to exercise is based on studies of untrained and moderately trained individuals. To use this knowledge to give training recommendations to elite runners is hardly valid. Researchers should therefore exercise caution when giving training recommendations to coaches and elite distance runners based on limited available research.
Comparison of perceptual and physiological variables of running on a track, motorized treadmill, and non-motorized curved treadmill at increasing velocity
Authors: Wee Veronika Myran , Von Heimburg Erna , Van den Tillaar Roland
Published: December 2016

The aim of this study was to compare perceptual and physiological variables between running on three different modalities — an indoor athletics track, a motorized treadmill, and a non-motorized curved treadmill — for 1000 m at three different velocities. Ten male athletes (age 24±3 years, body mass 69.8±6.91 kg, height 1.80±0.06 m, VO2peak 69.0±6.70 ml/kg/ min) conducted three 1000 m laps at increasing velocity on three different running modalities. The athletes had a 3-minute recovery between each lap, where the rate of perceived exertion (RPE) was registered and the blood lactate concentration and heart rate were measured. Oxygen uptake was measured using a portable metabolic analyser. The physiological (oxygen uptake, heart rate, and blood lactate concentration) and perceptual (RPE) variables were higher when running on a non-motorized curved treadmill compared with running on the track or a motorized treadmill. No differences were found between running on a motorized treadmill and the track except for the RPE, which was lower when running on the track compared with the motorized treadmill. Running on a non-motorized curved treadmill at three different velocities results in a higher oxygen uptake (37%) and heart rate (22%) and is subjectively much harder than running on a track or a motorized treadmill at the same velocities. The difference is around 4 km/h when comparing the physiological and perceptual responses. Thus, when performing training sessions on a non-motorized curved treadmill, subjects should subtract 4 km/h from their regular pace on a track or motorized treadmill to get the same response considering oxygen uptake, heart rate, RPE and blood lactate concentration.