bluuebunny/crossref_metadata_2025 huggingface dataset:
Friendship jealousy and interaction needs: how mutual friend features affect users of WeChat Moments
Authors: Zou Yehan , Han Xiqing , Yu Xudan , Zhang Yun , Shuai Qinghong
Published: October 2024

Many social networking services (SNSs) have features that highlight the common friends of pairs of users. Previous research has examined recommendation systems that use mutual friend metrics, but few scholars have studied how the existence of features related to mutual friends affects users in SNSs. To explore this issue further, we conducted interviews with 22 users of WeChat Moments to investigate how certain rules involving mutual friends affect users and how they deal with the issues that arise due to these rules. We found that the three Moments rules related to mutual friends (response visibility, response notifications, and information dissemination) can cause users to feel jealous, annoyed, and embarrassed. To prevent these negative experiences, users may reduce the amount of information they disclose or the frequency of their interactions in SNSs. Based on these findings, we propose several future directions for scholars and a small number of design suggestions aimed at assisting providers to satisfy users’ interaction needs.
Effects of short-form video app addiction on academic anxiety and academic engagement: The mediating role of mindfulness
Authors: Li Gongyu , Geng Yaxuan , Wu Tingting
Published: October 2024

Introduction

The impact of short-form video app addiction on academic performance, including academic anxiety and engagement, has not been adequately explored or addressed.

Method

This study tested the effects of short-form video app addiction on academic anxiety and academic engagement and the mediating role of mindfulness in these relationships. The participants were 1,879 undergraduates in China who completed the Short-Form Video App Addiction Scale, Mindful Attention Awareness Scale, Academic Anxiety Sub-questionnaire of Academic Emotions Questionnaire, and Engagement Scales. Structural equation modelling (SEM) was used to analyse the data.

Results

The results indicate that short-form video app addiction has significant positive effects on academic anxiety and negative effects on academic engagement. Furthermore, short-form video app addiction has significant indirect effects on academic anxiety and engagement via mindfulness. The proportions of the mediation effects are 19.23 and 51.85%, respectively.

Discussion

The implications and limitations of this study are discussed.
Personal views of aging in midlife and older age: the role of personality
Authors: Carbone Elena , Sella Enrico , Signori Diletta , Borella Erika
Published: October 2024

Introduction

Personal views of aging (VoA) reflect individuals’ perceptions, attitudes, and expectations regarding their aging selves. The present cross-sectional study was aimed at examining whether personality traits, as defined by the Big Five model, are associated with different VoA concepts related to both subjective age and awareness of age-related gains and losses in midlife and older age.

Materials and methods

A sample of 224 participants aged 46–85 years reported their felt age and completed the Awareness of Age-Related Change (AARC) questionnaire, assessing perceptions of age-related gains (AARC-Gains) and losses (AARC-Losses) in various functioning domains, as well as the short version of the Big Five Inventory.

Results

Linear regression models showed that Openness contributed to explain youthful subjective age. Extraversion explained higher AARC-Gains scores, whereas Emotional Stability, along with younger chronological age and perceiving better self-rated health, contributed to explaining lower AARC-Losses scores.

Discussion

These findings confirm the relationship between personality traits and personal VoA. They further suggest that such an association varies depending on the VoA measure considered. They underscore the importance of considering personality among those individual characteristics capable of shaping personal VoA, with implications for the development of tailored interventions and the understanding of the underlying mechanisms linking personal VoA to health and longevity outcomes in midlife and older age.
The effect of exercise motivation on college students’ self-efficacy: the mediating roles of leisure satisfaction and mental toughness
Authors: Yu Chengfeng , Zeng Zhaohong , Xue Aochuan , Wu Qianjin
Published: October 2024

Background

The theory of motivation suggests that individual motivation is moderately stimulated to drive individuals to engage in the behaviors for which they are motivated. It is therefore that the moderate stimulation of exercise motivation will likely lead to the enhancement of college students’ participation in exercise.

Objective

Investigate the effect of exercise motivation on college students’ self-efficacy, reveal the mediating role of leisure satisfaction and mental toughness, and provide empirical evidence improving college students’ self-efficacy through exercise motivation.

Methods

A stratified whole-sample approach was employed to survey 715 college students, based on a correlation table with good reliability and validity. Scale items were designed to collect subjects’ exercise motivation, self-efficacy, leisure satisfaction, and mental toughness in the study context. Mediation effect analyses were carried out using SPSS and AMOS.

Results and conclusion

A significant positive effect of exercise motivation on self-efficacy (β = 0.18, p < 0.001), leisure satisfaction (β = 0.50, p < 0.001), and mental toughness (β = 0.45, p < 0.001). Leisure satisfaction and mental toughness had a significant positive effect on self-efficacy (β = 0.40, p < 0.001; β = 0.30, p < 0.001). Furthermore, leisure satisfaction and mental toughness significantly mediated in exercise motivation and self-efficacy. In conclusion, our findings further explored the effects of exercise motivation on college students’ self-efficacy and revealed the mediating roles of leisure satisfaction and mental toughness.
The development of social learning: from pedagogical cues to selective learning
Authors: Ishikawa Mitsuhiko , Itakura Shoji
Published: October 2024

Learning new information from others, called social learning, is one of the most fundamental types of learning from infancy. Developmental studies show that infants likely engage in social learning situations selectively and that social learning facilitates infant information processing. In this paper, we summarize how social learning functions support human learning from infancy focusing on two aspects of social learning; pedagogical learning and selective learning. We also provide an overview of the developmental process of social learning based on the findings of developmental research. This review suggests that the learning facilitation effects of pedagogical learning decrease with development, while the facilitation effects of selective learning are observed even in older ages. The differences in these learning facilitation effects are considered to be due to the differences in the utility of learning in uncertain environments. The findings of the studies imply the unique nature of human social learning and the critical role of social interactions in cognitive development. Understanding the development of social learning provides valuable insights into how infants learn and adapt in complex social environments.
Solo music performance assessment criteria: a systematic review
Authors: Moura Nádia , Dias Pedro , Veríssimo Lurdes , Oliveira-Silva Patrícia , Serra Sofia
Published: October 2024

Assessment is a crucial aspect of music performance. In pedagogical contexts, an effective assessment process can measure student achievement and inform instructional decisions that contribute to improving teaching and learning. However, music performance assessment is particularly challenging due to its inherent subjectivity, involving personal expression and interpretation, which can lead to divergent opinions. In this PRISMA systematic review (registration DOI: 10.17605/OSF.IO/CSM8Q), we aimed to delimit and analyze solo music performance assessment systems found in the literature to date, including their corresponding evaluation categories and descriptive criteria, rating methodology, and target audience. A search in three main scientific databases (Web of Science, Scopus, ERIC) was conducted using keywords associated with the topic of assessment in the field of solo music performance. Ultimately, 20 papers were selected and examined, resulting in 26 original assessment systems for analysis. Regarding sample characteristics, we found that studies mainly focused on evaluating high school and university students, with music teachers and faculty members serving as primary evaluators. Many assessment systems were designed to be applicable across various instruments, although some were tailored to specific instruments (e.g., piano, voice) and families (e.g., brass, woodwind). Systems typically structured evaluation around technical, interpretative/expressive, and various musical feature categories (e.g., pitch, rhythm, intonation), further elaborated with descriptive items. While five-point Likert scales were commonly used, recent studies indicated a shift towards rubrics for detailed feedback, which aids examiners’ understanding and supports student progress. No differentiation was found in assessment criteria based on students’ learning stages, suggesting an area for improvement in refining these assessment methods. This study identifies gaps and proposes improvements in existing assessment systems, providing a foundation for educators and policymakers to enhance curriculum design and instructional practices in music education.
The aftermath of COVID-19: generalized anxiety disorder and burnout among radiology practitioners and interns in Saudi Arabia
Authors: Alshamrani Khalid M. , Alkenawi Abdulkader A. , Falatah Hebah A. , Alsulami Waad , Alzahrani Faisal A. , Nayta Tariq M. , Alharbi Abdulrahman H. , Alzahrani Mohannad A. , Almutairi Rahaf H. , Alshomrani Bander S. , Tasslaq Sameer E. , Aldhebaib Ali M.
Published: October 2024

Background

The coronavirus disease (COVID-19) pandemic has presented unprecedented stressors and difficulties for healthcare professionals. This study explored the prevalence of generalized anxiety disorders and burnout among radiology practitioners and interns in various hospitals in Saudi Arabia after the end of the COVID-19 global public health emergency.

Methods

A cross-sectional survey of 230 radiology practitioners and interns was conducted between October and November 2023. This study utilized the Generalized Anxiety Disorder 7-item (GAD-7) scale and Maslach Burnout Inventory-Human Services Survey for Medical Personnel (MBI-HSS-MP) 22-item questionnaire, employing a non-probability convenience sampling method. The average scores of the individual components constituting the GAD-7 scale and each burnout scale were calculated, and statistical analyses were conducted using the Mann-Whitney U and Kruskal-Wallis H nonparametric tests.

Results

Of 382 radiology practitioners and interns, 230 (60.2%) responded to the survey. Notably, 42.6% of the participants reported experiencing GAD. Regarding burnout, 82.3% were at moderate-to-high risk for emotional exhaustion, 93.5% for depersonalization, and 52.1% for personal achievement. The 31–40 years age group showed significantly higher burnout rates (p = 0.001) compared with the other age groups. Those with more than three years of experience had notably higher emotional exhaustion scores (p = 0.002) and a nearly significant increase in depersonalization scores (p = 0.051) than those with less experience.

Discussion

Our study revealed that 42.6% of radiology practitioners and interns experienced GAD, with the majority facing significant burnout. Furthermore, our research indicates a decline in GAD levels among radiology practitioners and interns compared with the peak COVID-19 pandemic period. It also showed a significant increase in both the incidence and severity of burnout, surpassing pre-pandemic levels in a comparable cohort. These findings emphasize the pressing challenges of GAD and burnout among healthcare workers, especially radiology professionals.
Prevalence of sleep disturbances in endometriosis patients: a systematic review and meta-analysis
Authors: Zhang Yujie , Liu Hui , Feng Chaochen , Yang Yadi , Cui Liwei
Published: October 2024

Objective

This study systematically analyzes the prevalence of sleep disturbance in patients with endometriosis.

Methods

The PubMed, Web of Science, Embase, Wanfang, China National Knowledge Internet Database (CNKI), China Science and Technology Journal Database were searched from their establishment to January 2024, using the search terms endometriosis and sleep disturbance to collect relevant literature on the prevalence of sleep disturbance in patients with endometriosis. Two researchers independently screened the literature, extracted data, and evaluated the risk of bias. The prevalence of sleep disorders in patients with endometriosis was systematically analyzed using Stata17.0 software.

Results

Sixteen studies with 2573 participants were included. The prevalence of sleep disturbance in patients with endometriosis was 70.8% (95% confidence interval: 60.7%~80.9%). The said prevalence was higher in China than in Iran and the European countries (78.2 vs. 57.6 vs. 64.4, Q=9.27, P=0.010) and increased significantly since 2018 (79.0 vs. 61.3, Q=3.97, P=0.046). This prevalence was significantly higher in the cohort study than that in cross-sectional and case-control studies (84.0 vs. 74.0 vs. 59.5, Q=7.16, P=0.028).

Conclusion

The prevalence of sleep disturbance is high in patients with endometriosis, particularly in China and its prevalence has increased significantly in recent years. Appropriate interventions are recommended to effectively prevent or minimize sleep disturbances in patients with endometriosis.
Role of health literacy on lifestyle and glycemic control among women with diabetes during pregnancy: a cross-sectional study
Authors: Babazadeh Towhid , Pourrazavi Sara , Ardeshiri Zahra , Nadi Akbar , Chollou Khalil Maleki
Published: October 2024

Background

The present study aimed to explore the impact of health literacy on the lifestyle of women with diabetes during pregnancy.

Methods

A cross-sectional study assessed the influence of some demographic characteristics and health literacy dimensions in predicting lifestyle and glycemic control in a sample of 230 women with diabetes during pregnancy. The data collection included a demographic form, a health literacy scale, and a lifestyle questionnaire. The data were analyzed using a one-way ANOVA and Pearson’s correlation coefficient. The predictors were determined using a hierarchical linear regression analysis.

Results

The participants had an average age of 27.74 years (SD = 6.54) and an average HbA1c level of 6.93% (SD = 1.93). Approximately 51.0% of the variation in lifestyle can be explained by health literacy (HL) and demographic variables (p-value <0.05). In addition, approximately 15.0% of the variation in HbA1c can be explained by health literacy, lifestyle, and demographic variables (p-value <0.05).

Findings

According to our findings, decision-making was found to be the strongest predictor of lifestyle. This study provides valuable information for nurses and other healthcare providers to help empower pregnant women to increase their health literacy and improve their lifestyle.
The leading causes of death in the US and Mexico’s pediatric population are related to violence: a note on secondary analyses of registered deaths from 2000 to 2022
Authors: Castilla-Peon Maria F. , Rendón Pablo L. , Gonzalez-Garcia Nadia
Published: October 2024

Introduction

our objective was to analyze the trends in the leading causes of death among the pediatric population aged 1–19 years in Mexico and the United States (US) from 2000 to 2022. Methods. Data for Mexico were sourced from the National Institute of Statistics and Geography (INEGI), while the US data were extracted from the Centers for Disease Control and Prevention’s Wide-ranging Online Data for Epidemiologic Research (CDC-WONDER) databases.

Results

Homicide has been the leading cause of death since 2017 in Mexico and since 2019 in US youths aged 1–19. In Mexico, it reached 6.5 deaths per 100,000 people in 2022. Despite the overall pediatric mortality decline from 2000 to 2022 in both countries, the pediatric homicide rate has increased by 93.3 and 35.8% In Mexico and the US, respectively, and suicide by 86.6 and 36.9%. In both countries, death by firearm-related injuries had risen in a parallel sense. In the US, deaths by drug overdose and poisoning have increased by 314.8%.

Conclusion

Despite advancements in infant healthcare over the past two decades in Mexico, there remains a significant gap in the provision of healthcare services to the adolescent population. Addressing issues related to violence, mental health, and substance abuse through targeted public policies is imperative for both Mexico and the US, especially given their shared border region.
The influence of minimum dietary diversity on undernutrition among children aged 6–23 months in Ethiopia: a multilevel mixed-effect analysis based on 2019 Ethiopian mini demographic and health survey
Authors: Shibeshi Abdu Hailu , Asfaw Zeytu Gashaw
Published: October 2024

Background

Undernutrition persists as a critical issue in developing countries like Ethiopia due to poor feeding practices for infants and young children. The impact of dietary diversity on children’s health in Ethiopia remains unclear, necessitating further investigation to develop effective prevention strategies.

Objective

To examine the association between minimum dietary diversity and undernutrition among children aged 6–23 months in Ethiopia.

Methods

Data from the 2019 Ethiopian Mini Demographic and Health Survey, including 1,501 women with children aged 6–23 months, were analyzed using STATA version 17 software. Child stunting, wasting, and underweight were assessed using Z-scores. Dietary diversity was measured using minimum dietary diversity. Multilevel logistic regression analysis determined associations, presenting results as crude odds ratios (COR) and adjusted odds ratios (AOR) with 95% confidence intervals (CI).

Results

Overall, 10.99% of children had adequate minimum dietary diversity, with Addis Ababa (44.57%) and Somalia (1.47%) showing the highest and lowest prevalences, respectively. The highest stunting prevalence was in the Amhara region (45.86%), while Addis Ababa had the lowest (9.78%). Wasting was lowest in Addis Ababa (1.09%) and highest in Tigray (17.07%). Underweight prevalence ranged from 2.17% in Addis Ababa to 33.33% in Tigray. Children with adequate minimum dietary diversity (MDD) had significantly lower odds of stunting (AOR = 0.68, 95% CI = 0.45, 0.96), underweight (AOR = 0.51, 95% CI = 0.27, 0.99), and wasting (AOR = 0.40, 95% CI = 0.17, 0.97) compared to those who had inadequate minimum dietary diversity (MDD).

Conclusion

This study highlights the association between minimum dietary diversity and stunting, wasting, and underweight among Ethiopian children aged 6–23 months. Urgent nutrition-specific interventions are needed, particularly in regions with high undernutrition rates and low dietary diversity. Targeted interventions focusing on promoting diverse and nutritious diets for children, along with improving access to essential healthcare services, are imperative to mitigate the burden of undernutrition and ensure the well-being of Ethiopia’s youngest population and reinforcing existing programs is crucial to address this public health issue effectively.
Respiratory pathogen analysis in pediatric inpatients unraveled the infection pattern of Mycoplasma pneumoniae post the COVID-19 pandemic
Authors: Chen Qihong , Xu Ruizhi , Gu Ying , Peng Jie , Ma Chiyuan , Su Dubin , Liu Shuai , Ge Dandan , Yang Yungang , Ning Wanshan
Published: October 2024

Background

To counteract the COVID-19 pandemic, nonpharmaceutical interventions (NPIs) were implemented globally, exerting a profound influence on a wide spectrum of infectious diseases, encompassing respiratory tract infections (RTIs). Subsequent to the easing of NPIs, China experienced a significant outbreak of Mycoplasma pneumoniae (MP).

Methods

Over a decade from 2015 to 2024, our study scrutinized 12 common infectious diseases among pediatric children. Etiologically diagnostic data and clinical outcome metrics of children with RTIs, tested for 13 pathogens, were analyzed to evaluate changes during and after the pandemic compared to pre-pandemic periods, with a notable emphasis on age profile and coinfection patterns of MP.

Results

Among 57,471 hospitalized children, 23,178 were diagnosed with infectious diseases. Under NPIs, most respiratory infections declined compared to pre-pandemic levels, rebounding by 69.64% in 2023. While the infection rate of common respiratory pathogens decreased, cases of respiratory syncytial virus increased during the period of extensive NPI implementation. In 2023, pediatric intensive care unit durations for these pathogens increased, suggesting greater severity of illness compared to 2019. MP exhibited the highest infection rate (31.38% average), with a notable outbreak post-pandemic due to severity increase in <3 year olds and rise among older children. NPIs reduced MP coinfections and mitigated their severity, while exerting a significant influence on bacterial coinfections with MP over the span of 5 years, in contrast to their impact on viral pathogens.

Conclusion

NPIs effectively curb transmission of respiratory infections by most pathogens, resulting in increased average age of MP infections and altered patterns of coinfection post-pandemic.
Systematic preoperative approach for bariatric surgery, perioperative results, and economic impact
Authors: Freire-Moreira Iolanda , Sanchez-Conde Maria Pilar , Sousa Gilles Barreira-de , Garrido-Gallego Maria Isabel , Rodríguez-López José María , Juárez-Vela Raúl , Bragado Juan Alonso , Carretero-Hernández Marta , Vargas-Chiarella Carlos Ricardo , Calderón-Moreno Jesús , Lorenzo-Gómez María Fernanda , Vaquero-Roncero Luis Mario
Published: October 2024

Introduction

Obesity is a complex systemic condition, involving numerous anatomical and metabolic changes. Therefore, a comprehensive preoperative assessment is essential for each patient contemplating bariatric surgery.

Objetive

This study presents the findings of a proposed protocol designed to streamline the pre-anesthesia consultation process. Our aim was to compare the efficiency and costs of consultations guided by the protocol with those conducted without a specific strategy. The secondary outcomes assessed included postoperative (PO) length of hospital stay and surgical duration.

Matherial and methods

We conducted a retrospective cross-sectional analysis involving 206 clinical cases. Statistical analyses, including the chi-squared test, Student’s t-test, and Mann–Whitney U test, were utilized based on the type of variables.

Results

The results showed a significant reduction in the costs, pre-anesthesia consultation duration, time spent in the recovery unit, and the need for referrals. However, no statistically significant differences were observed in the delay before surgery and length of hospital stays, measured in days.

Conclusion

This algorithm offers a promising approach for optimizing perioperative management in bariatric surgery, demonstrating its effectiveness in cutting costs and reducing the need for referrals.
The implementation of a “safety officer” program: an innovative approach to improve infection prevention and control practices in Ethiopia
Authors: Woldeamanuel Solomon Abebe , Thumba Linda , Gabul Warku Habte , Ahmed Kowsar , Mekonnen Gebeyehu Asire , Tarekegn Blen , Nhanala Aristides Cabral , Kent Paula S. , Ashengo Tigistu Adamu , Wu Albert W. , Dagoye Damtew Woldemariam , Curless Melanie S. , Fisseha Sarah , Ayalew Firew , Gebremichael Melaku , Hansoti Bhakti
Published: October 2024

Background

Effective infection prevention and control (IPC) was central to keeping healthcare workers (HCWs) safe during the COVID-19 pandemic. However, as the pandemic continued, the maintenance of high-quality IPC practices waned, placing HCWs at increased risk of infection. A COVID-19 Safety Officer (SO) program was piloted by the United States Agency for International Development (USAID)-funded Reaching Impact, Saturation and Epidemic Control (RISE) project across two health facilities in Ethiopia, which trained clinical and non-clinical HCWs on IPC protocols to promote safe practices in patient care areas. We sought to evaluate the implementation and effectiveness of the SO program in improving IPC practices within the clinical setting.

Methods

This is a post-implementation evaluation of the SO program, implemented in two hospitals in Ethiopia between May 2022 and December 2022. Participants completed a 4-day course on COVID-19 epidemiology, IPC, safety communication, and learning theory as a part of the Training of Trainers component (n = 23), and were posted in clinical wards to provide staff training and support to maintain IPC protocols. The program was evaluated at 6 months using the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework. Effectiveness was measured using direct observation of IPC practices across intervention sites. Implementation outcomes were measured using surveys and qualitative interviews to capture training cascade, knowledge, comfort, acceptability, and maintenance.

Results

Participants were able to cascade training to an additional 167 clinical (67.6%) and 80 non-clinical (32.3%) staff across both sites. Direct observation of clinical staff at 6 months showed that 95% (59/62) wore at least a surgical mask with patients and were compliant with masking and/or distancing protocol. Clinical interviews revealed that SOs contributed to increased perceived comfort with screening and isolation procedures and environmental cleaning procedures.

Conclusion

The SO training program was widely adopted, and effective in improving the implementation and comfort of maintaining IPC practices in clinical settings.
The impact of a positive discipline group intervention on parenting self-efficacy among mothers of young children
Authors: Liu Jian , Liu Xiaojuan , Ding Meifang
Published: October 2024

Introduction

Instilling healthy behaviors in early childhood is crucial as they can have lifelong impacts. However, many Chinese mothers lack effective parenting strategies, resulting in low self-efficacy. Positive Discipline, a non-punitive and non-indulgent approach, can help enhance maternal parenting self-efficacy and promote healthy lifestyle behaviors in children. This study explores the impact of a Positive Discipline group intervention on the parenting self-efficacy of Chinese mothers and how it can contribute to promoting diet and healthy lifestyle behaviors in early childhood.

Methods

We randomly selected 70 mothers with low parenting self-efficacy from a kindergarten in China, dividing them into an intervention group (35 participants) and a control group (35 participants). The intervention group received a 6-week Positive Discipline intervention, while the control group received no intervention. The intervention aimed at helping mothers nurture their children in a kind and firm manner. We used paired samples t-tests and independent samples t-tests to compare changes in parenting self-efficacy scores before and after the intervention.

Results

Results showed that the intervention group's parenting self-efficacy scores significantly improved after the intervention, from an average score of 25.00 ± 4.08 to 36.29 ± 2.99 (p < 0.05, Cohen's d = 3.156). Significant improvements were observed in areas like “believing their parenting style benefits their child's growth” and “knowing how to effectively parent their children.” The control group's average scores showed no significant changes between pre- and post-intervention (pre: 25.07 ± 5.33; post: 24.86 ± 5.75, p > 0.05, Cohen's d = 0.076). Furthermore, 3 months post-intervention, the intervention group's scores remained significantly higher than pre-intervention (p < 0.05), demonstrating the intervention's lasting effect.

Conclusion

This study demonstrates that the Positive Discipline group intervention significantly enhances parenting self-efficacy in Chinese mothers, promoting healthy lifestyle behaviors in early childhood. Providing continuous support and guidance to mothers can help solidify their parenting confidence, ensuring long-term intervention success. Future research should explore how group interventions can effectively integrate healthy behaviors into early childhood routines and impact children's diet and lifestyle behaviors.
Handwashing sinks as reservoirs of carbapenem-resistant Acinetobacter baumannii in the intensive care unit: a prospective multicenter study
Authors: Wei Li , Feng Yu , Lin Ji , Kang Xia , Zhuang Hongdi , Wen Hongxia , Ran Shasha , Zheng Lan , Zhang Yujing , Xiang Qian , Liu Yan , Wu Xueqin , Duan Xiaofei , Zhang Wensheng , Li Qu , Guo Hua , Tao Chuanmin , Qiao Fu
Published: October 2024

Introduction

The extent to which sinks are contaminated by carbapenem-resistant Acinetobacter baumannii (CRAB) in intensive care units (ICUs) and the association between these contaminated sinks and hospital-acquired CRAB infections during the non-cluster period remains largely unknown. Here, we performed a prospective multicenter study in 16 ICUs at 11 tertiary hospitals in Chengdu, China.

Methods

We sampled sinks, collected CRAB clinical isolates, and conducted whole-genome sequencing and analysis.

Results

A total of 789 swabs were collected from 158 sinks, and 16 CRAB isolates were recovered from 16 sinks, resulting in a contamination rate of 10.16%. Twenty-seven clinical isolates were collected during the study period. The majority (97.67%, 42/43) of the CRAB isolates belonged to ST2, and 36 (83.72%) of them had both blaOXA-23 and blaOXA-66. The 43 strains belonged to 12 clones. One certain clone caused multiple contaminations of seven sinks in one GICU. Two clones of ST2 blaOXA-23 and blaOXA-66-carrying sink strains were likely the sources of the two clusters in the two GICUs, respectively. Five ST2 blaOXA-23-carrying isolates were found to be common clones but were recovered from two hospitals.

Conclusion

The contamination rate of CRAB in handwashing sinks is high in some local ICUs, and the contaminated sinks can serve as environmental reservoirs for CRAB clusters.
Predicting clinical trial success for Clostridium difficile infections based on preclinical data
Authors: Li Fangzhou , Youn Jason , Millsop Christian , Tagkopoulos Ilias
Published: October 2024

Preclinical models are ubiquitous and essential for drug discovery, yet our understanding of how well they translate to clinical outcomes is limited. In this study, we investigate the translational success of treatments for Clostridium difficile infection from animal models to human patients. Our analysis shows that only 36% of the preclinical and clinical experiment pairs result in translation success. Univariate analysis shows that the sustained response endpoint is correlated with translation failure (SRC = -0.20, p-value = 1.53 × 10−54), and explainability analysis of multi-variate random forest models shows that both sustained response endpoint and subject age are negative predictors of translation success. We have developed a recommendation system to help plan the right preclinical study given factors such as drug dosage, bacterial dosage, and preclinical/clinical endpoint. With an accuracy of 0.76 (F1 score of 0.71) and by using only 7 features (out of 68 total), the proposed system boosts translational efficiency by 25%. The method presented can extend to any disease and can serve as a preclinical to clinical translation decision support system to accelerate drug discovery and de-risk clinical outcomes.
HoLLiECares - Development of a multi-functional robot for professional care
Authors: Schneider Julian , Brünett Matthias , Gebert Anne , Gisa Kevin , Hermann Andreas , Lengenfelder Christian , Roennau Arne , Schuh Svea , Steffen Lea
Published: October 2024

Germany’s healthcare sector suffers from a shortage of nursing staff, and robotic solutions are being explored as a means to provide quality care. While many robotic systems have already been established in various medical fields (e.g., surgical robots, logistics robots), there are only a few very specialized robotic applications in the care sector. In this work, a multi-functional robot is applied in a hospital, capable of performing activities in the areas of transport and logistics, interactive assistance, and documentation. The service robot platform HoLLiE was further developed, with a focus on implementing innovative solutions for handling non-rigid objects, motion planning for non-holonomic motions with a wheelchair, accompanying and providing haptic support to patients, optical recognition and control of movement exercises, and automated speech recognition. Furthermore, the potential of a robot platform in a nursing context was evaluated by field tests in two hospitals. The results show that a robot can take over or support certain tasks. However, it was noted that robotic tasks should be carefully selected, as robots are not able to provide empathy and affection that are often required in nursing. The remaining challenges still exist in the implementation and interaction of multi-functional capabilities, ensuring ease of use for a complex robotic system, grasping highly heterogeneous objects, and fulfilling formal and infrastructural requirements in healthcare (e.g., safety, security, and data protection).
Could Humans Use Grasshoppers’ Secrets to Jump Higher?
Authors: Ruggiero Luca , Luciano Francesco , Gruber Markus , Clemente Christofer J.
Published: October 2024

For humans, the ability to jump is an indicator of physical fitness and the ability to move well. To figure out how to jump higher, one solution is to look at animals that do it very well, like grasshoppers. These animals have a tiny mechanism in their knees that works like a sling and enables them to jump very high. Given how well this sling-like mechanism works, could bigger animals—or humans—use it to make huge jumps? The answer, surprisingly, is no: increasing body size makes animals better at producing energy with sling-like mechanisms, but it also increases the energy required to achieve the same jump height. By reading this article, you will learn how physics and geometry help biologists answer a question about how animals move. Let us jump right in!
Are there kinematic and kinetic parameters correlated with racket velocity during the tennis serve? A preliminary comparison between a slow and a fast serve for performance improvement
Authors: Gorce Philippe , Jacquier-Bret Julien
Published: October 2024

Introduction

The tennis serve is a complex motion with numerous rotations which are important to manage for performance. The main aim of this study was to investigate kinematic parameters, including the evolution of the center of gravity, and kinetic parameters correlated with racket velocity over all phases of the tennis serve. The secondary objective was to find out which of the correlated parameters differed between a slow and a fast serve. The advantage of such an approach would be to propose biomechanical parameters that coaches and teachers could use to optimize performance or learn how to serve.

Methods

Quantitative analysis was carried out on 5 flat serves performed by four ranked players using an optoelectronic system (82 markers located on whole body and racket) composed of 10 infrared cameras (150 Hz) and two force platforms (750 Hz).

Results

A descriptive statistical analysis highlighted 11 very large and almost perfect correlations with racket velocity: vertical ground reaction force of back foot in release backward, trunk axial rotation during loading phase, back and front knee flexions, dominant shoulder and hip mediolateral rotation during cocking phase, and center of gravity vertical velocity, dominant shoulder medial rotation velocity, dominant elbow flexion, trunk flexion/extension and axial rotation during acceleration phase. Differences were observed for some of the correlated parameters between slow and fast serve.

Discussion

Consequently, all these correlated kinematic and kinetics parameters constitute information that coaches, instructors and athletes can use to improve, optimize or teach the tennis serve.
Five paradoxes navigated by incumbent private sector firms moving towards climate-oriented innovation in food systems
Authors: Zeppenfeldt Leanne , Dinesh Dhanush , Vellema Sietze
Published: October 2024

The role of large private sector firms in rerouting our food systems towards sustainability through climate-oriented innovation is highly contested. The contestation has resulted in a portrayal in academic literature of these incumbents as either the key driver of sustainability transitions or as fundamentally contradictory to addressing climate change in food systems. Controversies and tensions can reinforce stalemates, which hamper progress towards climate-oriented innovation. This study explores the utility of a paradox lens which shifts the research gaze to the emergence of unavoidable and persistent tensions in encounters of distinct logics and lines of action, and opens space to examine how these encounters can nevertheless be used productively and creatively in overcoming stalemates. Based on reflexive practice and interviews with professionals from seven purposefully selected incumbent private sector firms in the agri-food sector, we identify five paradoxes: the paradox of direction—between mitigation and adaptation; the paradox of justification—between exploration and exploitation; the paradox of internal alignment—between mainstreaming and specialization; the paradox of external alignment—between collaboration and competition; and the paradox of evidence—between accountability and learning. Our analysis of how agri-food firms navigate paradoxes focuses on considerations, tensions, and decisions in organizing climate-oriented innovation. In our discussion, we examine whether and how paradoxical thinking enables civil society practitioners to accelerate climate-oriented innovation in food systems through interactions and collaborations with the private sector. We conclude that a paradox lens affords researchers, practitioners, and policymakers to move beyond the binary view on the role of incumbents’ climate-oriented innovation, and instead provides strategic insights for engaging incumbents and their inherent contradictions in transforming our food systems under a changing climate.
Esophagojejunostomy using a circular stapler vs. a linear stapler for gastric cardia cancer patients: impact of upper margin length and tumor size on the survival rate
Authors: Dieudonne Maniragaba , Lv Renguang , Xie Wenjie , Liu Qi , Jiang Jianwu , Fu Yang
Published: October 2024

Background

The incidence of gastric cancer is concomitantly rising with gastric cardia cancer worldwide. While the improvement of gastric cancer surgical techniques is glowing, this study assesses the impact of the upper margin length and tumor size on the survival rate for gastric cardia cancer patients who underwent total laparoscopic total gastrectomy(TLTG) or laparoscopic assisted total gastrectomy(LATG).

Materials and methods

A total of 63 patients with gastric cardia cancer who underwent laparoscopic total gastrectomy were retro-prospectively collected from January 2021 to May 2023. While assessing the impact of upper margin length and tumor size on the survival rate, esophagojejunostomy using a linear stapler has been compared to a circular stapler.

Results

The sixty-three patients met inclusion criteria; 32 (51%) underwent LATG and 31 (49%) underwent TLTG. Their mean age was 65 years (range, 45–77). The blood loss means in LATG and TLTG was 74.69 and 50.16 ml, respectively (p = 0.005), and surgery duration was higher in LATG than LATG with respective means of 247 min and 222.42 min. (p = 0.006). However, the tumor size means (p = 0.5), and upper margin length means (p = 0.052) were not significantly different in the LATG and TLTG groups, respectively. The number of resected and assessed lymph node was adequate in the LATG and TLTG groups. The current study still does not find an independent related risk from the upper margin length and tumor size to the survival rate according to the multiple regression analysis (p = 0.080).

Conclusion

The upper margin length and tumor size do not have a relationship with the survival rate of the compared esophagojejunostomy (EJS) methods. The EJS using a linear stapler requires a shorter surgery duration and less blood loss than EJS using a circular stapler.
Fish welfare in farms: potential, knowledge gaps and other insights from the fair-fish database
Authors: Maia Caroline Marques , Saraiva João Luis , Gonçalves-de-Freitas Eliane
Published: October 2024

An adequate understanding of fish behaviors and their interaction with farm-specific environments is pivotal for enhancing fish welfare in aquaculture. The fair-fish database aims to provide a consistent overview of the welfare of farmed fish. This platform consolidates ethological knowledge into profiles of farmed aquatic species. Its WelfareCheck profiles are organized around welfare indicators, with each criterion receiving classifications (no findings, unclear, low, medium, and high) regarding the likelihood and potential for individuals of a given species to experience good welfare in aquaculture systems, along with the associated certainty level. These criteria include home range, depth range, migration patterns, reproduction, aggregation patterns, aggressive behavior, substrate needs, stress responses, malformations, and slaughtering protocols. We investigated which of these 10 criteria are most relevant to the overall welfare of a species, considering the likelihood, potential, and certainty of good welfare in aquaculture. To achieve this, we reviewed and recorded the high classifications across each criterion and dimension from all published WelfareCheck profiles. To further investigate knowledge gaps across the criteria, we also recorded classifications marked as unclear and no findings. These were then compared across the criteria to assess the frequency of such classifications. While no significant differences were found between the criteria regarding the likelihood that the surveyed species meet their basic welfare needs, criteria related to reproduction, slaughter practices, and substrate needs demonstrated a high potential for better welfare outcomes. Moreover, reproduction and migration patterns exhibited high certainty in the available literature. Based on these findings, we conclude that improving the reproduction of farmed aquatic species, considering their natural needs and behavior, could be an effective and reliable approach to improving welfare. However, we also found a low certainty of information on aggression and an absence or conflicting data on home range, aggregation patterns, stress, and malformations. This highlights an urgent need for research in these areas, which are fundamental for developing more accurate assessments and recommendations for farmed aquatic species.
Periodontal ligament stem cell tissue engineering scaffolds can guide and promote canine periodontal tissue regeneration
Authors: Dai Pengxiu , Qi Guixiang , Zhu Mingde , Du Qingjie , Wang Keyi , Gao Yaxin , Li Mengnan , Feng Xiancheng , Zhang Xinke
Published: October 2024

Background

The immunogenicity of allogeneic mesenchymal stem cells (MSCs) is significantly enhanced after transplantation or differentiation, and these cells can be recognized and cleared by recipient immune cells. Graft rejection has become a major obstacle to improving the therapeutic effect of allogeneic MSCs or, after their differentiation, transplantation in the treatment of diabetes and other diseases. Solving this problem is helpful for prolonging the time that cells play a role in the recipient body and for significantly improving the clinical therapeutic effect.

Methods

In this study, canine adipose-derived mesenchymal stem cells (ADSCs) were used as seed cells, and gene editing technology was used to knock out the B2M gene in these cells and cooperate with the overexpression of the PD-L1 gene. Gene-edited ADSCs (GeADSCs), whose biological characteristics and safety are not different from those of normal canine ADSCs, have been obtained.

Results

The immunogenicity of GeADSCs is reduced, the immune escape ability of GeADSCs is enhanced, and GeADSCs can remain in the body for a longer time. Using the optimized induction program, the efficiency of the differentiation of GeADSCs into new islet β-cells was increased, and the maturity of the new islet β-cells was increased. The immunogenicity of new islet β-cells decreased, and their immune escape ability was enhanced after the cells were transplanted into diabetic dogs (the graft site was prevascularized by the implantation of a scaffold to form a vascularized pouch). The number of infiltrating immune cells and the content of immune factors were decreased at the graft site.

Conclusions

New islet β-cell transplantation, which has low immunogenicity, can reverse diabetes in dogs, and the therapeutic effect of cell transplantation is significantly enhanced. This study provides a new method for prolonging the survival and functional time of cells in transplant recipients and significantly improving the clinical therapeutic effect.
Ultrasonography for non-invasive sex identification and reproductive assessment in Nile tilapia (Oreochromis niloticus)
Authors: Setthawong Piyathip , Khemthong Matepiya , Lertwanakarn Tuchakorn , Surachetpong Win
Published: October 2024

Sex identification and the selection of monosex male tilapia are crucial for tilapia aquaculture. In this study, we evaluated the application of ultrasonography as an alternative procedure for sex identification and reproductive assessment in Nile tilapia (Oreochromis niloticus). Ultrasonography was performed on 23 fish weighing 232–1,281 g to capture longitudinal and transverse images of the ovaries and testes. Female tilapia were identified by the presence of numerous small egg granules and gray or light gray ovarian tissue and male tilapia by the homogeneous echogenicity and uniform gray tubular appearance of the testes. These distinct echogenic patterns allowed for accurate differentiation between the female and male fish. Ultrasonography achieved a 95% accuracy in sex identification, with minimal stress to the fish during the procedure, compared to manual sex sorting, which demonstrated an accuracy of 87%. Furthermore, the method facilitated the assessment of the reproductive status of the fish, including the maturation stages and fecundity potential. The use of ultrasonography offers significant advantages over traditional methods, such as animal welfare enhancements and improved breeding program efficiency. Our findings support the integration of ultrasonography into aquaculture practices and will promote sustainable and humane fish farming while optimizing reproductive management and productivity.