bluuebunny/crossref_metadata_2025 huggingface dataset:
EKSPLORASI ETNOMATEMATIKA PADA KERAJINAN KAYU DI DESA TUTUL KECAMATAN BALUNG SEBAGAI BAHAN AJAR GEOMETRI
Authors: Kholifatuzzuhro Aina , Sunardi Sunardi , Monalisa Lioni Anka
Published: February 2021

This study aims to explore anything ethnomatematics related to woodwork in Tutul Village, Jember. Woodcraft is a craft made from wood. This type of research is a study using a qualitative approach with ethnographic design. Research subjects in this study were craftsmen and owners of "Ara Collections" wood production houses. In this study the object is focused on bracelets, necklaces, and keeping. Based on the results of the study, it can be seen that wood crafts have mathematical elements. The mathematical elements found are ball, tube, cube, integrated cone, rectangular flat, circle, parabolic, ellipsoid, hyperbole, hyperbole, geometric patterns, reflection, dilation, and congruence and concordance. The teaching material made is in the form of a geometry test package related to ethnomatematics in wood crafts in Tutul Village, Balung Sub-District, Jember.

 

Keywords: Ethnomatematics; Woodcraft; Geometry; Teaching Materials
“You’re the boss, yo!”: Role-Play in Digital Multimodal Composition of Newcomer Youth
Authors: Michalovich Amir
Published: February 2021

This case study explores how two 16-year-old newcomer youth in a Canadian secondary school navigated the digital multimodal composition process through role-play in their first digital video production at school. Employing a qualitative, case-study design, the study shows how the youth playfully accentuated collaborative over coercive power relations, as well as repositioned and represented their imagined identities as they played different assigned roles in the filmmaking process. The implications of these findings are discussed for educators and researchers considering digital multimodal composition as a classroom literacy practice.
Genre Expectations and Viewer Reaction to Our Planet: Are Audiences Motivated to Act More Sustainably?
Authors: Ahn Claire
Published: February 2021

As more people turn to documentaries to learn about environmental issues it becomes even more important to consider the ways in which genre and its representational patterns, such as the use of images, affect viewers. Re-examining the multiliteracies framework and grounded in rhetorical genre studies, this paper explores the first two episodes of Our Planet, a Netflix docu-series that catalyzed strong responses based on two jarring image sequences. The purpose of this paper is to examine how our familiar understandings of particular genres impacts our understanding of particular issues and what happens when the familiar patterns of a genre are challenged.
Vulnerabilidade atual e natural à erosão do solo na sub-bacia hidrográfica do Ribeirão Floresta, no município de Cachoeiro de Itapemirim, Espírito Santo, Brasil
Authors: Fiorese Caio Henrique Ungarato
Published: February 2021

Estudos voltados à erosão dos solos de uma bacia hidrográfica são de extrema importância, principalmente em áreas onde há carência de pesquisas com essa temática, pois auxiliam em diversas tomadas de decisões ambientais. O objetivo deste trabalho foi verificar a erosão atual e potencial na sub-bacia hidrográfica do Ribeirão Floresta (ES), a fim de subsidiar melhorias quanto à conservação dos solos associada a produção econômica. Os procedimentos foram realizados no programa ArcGIS, considerando uma base de dados geográficos. Inicialmente, foi delimitada a sub-bacia. O modelo matemático considerado foi a Equação Universal de Perda de Solos, estimando-se os seguintes dados: erosividade, erodibilidade, comprimento de rampa, declividade e fatores uso e manejo do solo e práticas conservacionistas. Foram estimadas, classificadas e mapeadas as erosões atual e potencial. Quanto à erosão potencial, as classes compreendidas de moderada a muito forte somam 73,98%, sendo um valor muito expressivo. Há maior tendência natural à erosão na porção norte da BHRF, ao passo que, nas regiões central e sul, predominam intensidades menores. Isso pode ser justificado pelas irregularidades do relevo. Quando somadas, as classes compreendidas de “moderada a alta” a “extremamente alta” correspondem a 48,33%. Portanto, quase metade está susceptível à perda de solo atual considerando o uso e manejo do solo e práticas conservacionistas, o que pode ser atribuído às formas de ocupação das terras. As áreas naturalmente menos vulneráveis estão ocupadas por atividades que agravam a ocorrência de erosão, ao passo que as áreas potencialmente mais susceptíveis possuem formas de ocupação capazes de proteger o solo. Há necessidade de um melhor planejamento de ocupação da terra através da integração de comitês e gestores públicos com os moradores da sub-bacia. Espera-se que este trabalho contribua para diversas melhorias acerca da conservação dos solos na região.
Efek Pemberian Biskuit Ikan Patin (Pangasius hypophthalmus) Dengan Jenis Tepung Yang Berbeda Terhadap Pertambahan Berat Tubuh Mencit
Authors: Firlianty Firlianty
Published: February 2021

The objective of the study was to know the effect of biskuit made of different flour materials mixed with catfish (Pangasius hypophthalmus) on the body weight increment of rat. This study was conducted from January - May 2020 under an experimental method. It used Complete Randomized Design with 4 treatments and 3 replications: catfish biskuit processed with flour (O), tapioca (A), rice flour (B), cornstarch (C). Results showed that the administration of catfish (Pangasius hypophthalmus) biscuit processed with different flour highly significantly influenced the weight increment of the rat.
The Development of Government Effectiveness Evaluation Practices: Global Trends and the Experience of the USA
Authors: Khakhunova A.
Published: February 2021

The article considers the main tendencies of the government effectiveness evaluation practices development in the world. The investigation begins with its origins in the budgetary reform and, widely, the concept of New Public Management. The paper also examines the so called evaluation waves, stages of development and methods that have been used at each stage. At present, the government effectiveness evaluation is associated directly with strategic planning and finances. The main question is: to what extent the results obtained impact on further decisions, do the evaluations affect future budgets and policy implementation plans? Special attention is paid to American experience, since the USA is the leader in development and implementation of effective governmental practices. During a long history of such practices in the United States they have undergone numerous significant changes. However, this issue is very complicated and is not fully resolved even at present. The US experience is highly relevant and useful for Russia, where the public administration reform is still important. In Russia there are both projects and measures corresponding with the world tendencies in the government effectiveness evaluation field. At the same time, the adoption of foreign institutions may lead to negative results. The future of evaluation practices in Russia, on federal and regional level, pivots on development of relevant homegrown institutions and mechanisms in compliance with positive and negative international experience.
Prize without Victory, Victory without Prize
Authors: Grishin I.
Published: February 2021

Traditional stability of the Swedish legislative and executive authorities functioning, manifested in the almost complete absence of parliamentary and governmental crises, was questioned by results of the general elections in September 2014. The Alliance of four center-right parties who ruled Sweden from 2006 to 2014 suffered a defeat having lost 32 of 173 mandates. Simultaneously, the informal coalition of three center-left parties that opposed to the Alliance in 2006-2014 increased its representation in the Riksdag from 156 to 159 deputies only. Thus, none of the two inter-party blocks has the absolute parliamentary majority (175) needed for the formation of the own government. At the same time, Sweden Democrats who first entered the Riksdag in 2010 have significantly increased their faction (from 20 to 49 deputies) and thereby strengthened their king maker position (holding the balance of power) in the new parliament. Yet this party is isolated and excluded from the cross-party interaction in the Riksdag because of its Islamofobia and anti-immigrant attitudes. The new government of minority (the Social Democrats and the Green Party) was approved by the Riksdag due to the negative parliamentarism principle which means that the government shall be deemed approved if it does not receive the absolute majority of votes against it. However, many subsequent government bills submitted to the Riksdag are likely to be rejected by the opposition parties of the Alliance with assistance of the Sweden Democrats. To avoid such situation, the government parties have to bargain with smaller center-right parties on particular issues and thus to form a required ad hoc parliamentary majority. After the last elections, the political establishment parties became much more dependent in their interaction on the Sweden Democrats' unpredictable behavior than before. All of these factors greatly complicate the Riksdag's and the government's work as well as sharply increase risks of governmental and parliamentary crises even to the extent of the government's resignation and pre-term elections. It is unusual for Sweden where such elections last took place in 1958.
Contribution of High Growth Enterprises in Solving Problems of Employment
Authors: Olevsky G.
Published: February 2021

Promotion of rapidly growing enterprises (“gazelles”) is an essential condition for successful solution of employment problems. Priority should be granted to support of high growth enterprises in high technology manufacturing and knowledge-intensive business services. Dissemination process of such enterprises in each country is characterized by a certain industry-specific factors. Author’s analysis of statistical information allows to conclude that the high-tech manufacturing industries do not play a significant role in solving the problems of employment. They are capable for only partial compensation of the loss of jobs in labor-intensive sectors of the economy. Accumulation of the population of industrialized countries knowledge together with high levels of computer literacy contributed to the revitalization of business services sellers. The article proceeds from the assumption that the business services’ sectors and especially in the field of business services to a certain extent are capable of absorbing additional workforce. The author argues that employment in the services sector in the EU is still largely focused on traditional sectors of activity. Knowledge-intensive services that are important from the point of view of economic dynamics, gain positions only in several markets. One of the reasons is insufficient attention of politicians, scientists and civil society of EU member states to the business knowledge-intensive services market. Analysis of the prospects of high growth enterprises’ expansion is based on the concept duality of modern worker’s market status. Namely, a worker can simultaneously be an employee and entrepreneur or regularly alternate activities as self-employed and employed worker.
Enhancing sengon seedling’s growth by using indigenous arbuscular mycorrhiza from tropical peatland
Authors:   Balai Penelitian dan Pengembangan Lingkungan Hidup dan Kehutanan Banjarbaru, Yuwati Tri Wira
Published: February 2021

The research aimed to determine the effect of arbuscular mycorrhizal isolates from Central Kalimantan peat swamp forest on the growth of sengon (Falcataria moluccana (Miq) Barneby & Grimes). Arbuscular mycorrhizal isolates consisted of Glomus sp.2 (blackish brown) & Glomus sp.3 (dark brown) isolated from the peatland of Central Kalimantan. The mycorrhizal colonization was observed and plant growth parameters were measured for five months. The design used in this research was a complete randomized design and there were 6 treatments including Glo1S2 (Glomus sp.2, 2 spores), Glo1S4 (Glomus sp.2, 4 spores), Glo2S2 (Glomus sp.3, 2 spores), Glo2S4 (Glomus sp.3, 4 spores), control I and control II. The result showed that arbuscular mycorrhiza colonization significantly different between the treatments of inoculation compared with control. Glo2S4 treatment gave a significant effect on the growth of sengon in terms of plant height, stem diameter, number of leaves, root length and total biomass. Keywords: AMF, spore, Glomus, Kalimantan
RUSLE Model Based Annual Soil Loss Quantification for Soil Erosion Protection in Fincha Catchment, Abay River Basin, Ethiopia.
Authors: Tamiru Habtamu , Wagari Meseret
Published: February 2021

The quantity of soil loss as a result of soil erosion is dramatically increasing in catchment where land resources management is very weak. In this paper, a RUSLE model-based soil loss quanti-fication technique is presented to estimate the annual soil loss and identify the severity of the erosion in the catchment. This study uses Fincha catchment in Abay river basin as the study area to quantify the annual soil loss by implementing Revised Universal Soil Loss Equation (RUSLE) model developed in ArcGIS version 10.4. Digital Elevation Model (12.5 x 12.5), LANDSAT 8 of Operational Land Imager (OLI) and Thermal Infrared Sensor (TIRS), Annual Rainfall of 10 stations and soil maps of the catchment were used as input parameters to generate the significant factors. Rainfall erosivity factor (R), soil erodibility factor (K), cover and management factor (C), slope length and steepness factor (LS) and support practice factor (P) were used as soil loss quantification significant factors. A model builder for the RUSLE model was developed and raster map calcula-tion algebra was applied in ArcGIS version 10.4 to quantify the total annual soil loss. It was found that the quantified average annual soil loss ranges from 0.0 to 76.5 t ha-1 yr-1 was obtained in the catchment. The area coverage of soil erosion severity with 55%, 35% and 10% as low to moderate, high and very high respectively were identified. The information about the spatial variation of soil loss severity map generated in RUSLE model has a paramount role to alert land resources man-agers and all stakeholders in controlling the effects via implementation of both structural and non-structural mitigations. The results of the RUSLE model can also be further considered along with the catchment for practical soil loss quantification that can help for protection practices.
PENGEMBANGAN APLIKASI ANDROID UNTUK PEMBELAJARAN PNEUMATIK
Authors: Setiadi Anwar , Yuliatmojo Pitoyo , Nurhidayat Diat
Published: February 2021

Penelitian ini merupakan pengembangkan aplikasi android untuk pembelajaran pneumatik dengan mengetahui tingkat kelayakannya aplikasi berdasarkan penilaian ahli materi, ahli media, praktisi pembelajaran pneumatik (guru), dan siswa. Penelitian menggunakan metode pengembangan (Research and Development) yang diadaptasi dari model pengembangan ADDIE (Analisis, Design, Development, Implementation, and Evaluation), Hasil Penelitian menunjukan bahwa tingkat kelayakan aplikasi android  pembelajaran pneumatik mendapatkan penilaian berdasarkan : 1) ahli materi diperoleh rata-rata skor 4.55 yang termasuk kategori sangat layak, 2) ahli media diperoleh rata-rata skor 4.31 yang termasuk kategori sangat layak, 3) praktisi pembelajaran pneumatik (guru) diperoleh rata-rata skor 4.54 yang kategori sangat layak, dan 4) Siswa diperoleh rata-rata skor 4.03 yang termasuk kategori layak. Maka dapat disimpulkan bahwa pengembangan aplikasi android untuk pembelajaran pneumatik layak digunakan sebagai multimedia pembelajaran interaktif dalam pembelajaran pneumatik.
PERANCANGAN DAN IMPLEMENTASI PERAGA BAHASA ISYARAT MENGGUNAKAN TANGAN ROBOT UNTUK PENDERITA TUNA RUNGU
Authors: Angga Muhammad , Pitoyo Yuliatmojo  , Taryudi
Published: February 2021

Tuna Rungu adalah orang yang sedang mengalami gangguan pada organ pendengarannya, sehingga tidak bisa memahami orang normal dalam mendengar maupun berkomunikasi dengan baik di lingungan sekitarnya, bahasa isyarat merupakan salahsatu dari cara berkomunikasi dengan penderita Tuna Rungu. Metode penelitian yang dipakai penulis adalah dengan metode research and development. Penelitian dengan berjudul “Perancangan dan implementasi peraga bahasa isyarat menggunakan tangan robot untuk penderita Tuna Rungu” bertujuan membuat sistem yang memiliki prinsip kerja sebagai alat peraga robot bahasa isyarat satu tangan, yang terdapat pada kamus bahasa isyarat indonesia, yaitu dengan cara menampilkan gestur atau isyarat visual alphabet dan angka lalu digerakan dengan motor servo melalui aplikasi android dan mikropon pengenalan suara. Tangan robot peraga bahasa isyarat menggunakan 11 Motor servo sebagai penggerak atau aktuator pada setiap jari-jari, dan pergelangan robot untuk inputnya yang pertama menggunakan menggunakan Voice Recognition EasyVR, EasyVR adalah salahsatu modul voice recognition modul ini berfungsi sebagai penerima perintah suara, ketika microphone menerima suara yang masuk yaitu berupa salahsatu alphabet maka proses di dalam modul EasyVR akan menerima perintah lalu data masukan tersebut akan diproses dalam arduino, keluaran arduino akan mengaktifkan motor servo sehingga membentuk gestur yang terdapat pada bahasa isyarat serta akan menampilkan pada layar LCD 16x2 Huruf dan Angka yang diucapkan melalui microphone EasyVR, dan input yang kedua menggunakan aplikasi pada android yang dibuat sendiri menggunakan software MIT app Inventor. Hasil Penelitian Tangan Robot Bahasa Isyarat dapat direalisasikan dengan penggabungan sub-sistem yang berfungsi dengan baik, diantaranya : Arduino Mega 2560, Modul Voice Recognition EasyVr, Sistem Display berbasis LCD 16x2 dan I2C, Modul Bluetooth, 32 Channel servo controller, dan Baterai Li-Po. Sistem Tangan Robot Bahasa Isyarat menggunakan bahan plastik (Pla) yang dicetak menggunakan 3D Printer dan Tangan Robot Bahasa Isyarat dapat digerakan dengan aplikasi android yang dapat di unduh, dan sensor suara, lalu dapat bergerak otomatis menampilkan gestur atau isyarat visual yang sudah terprogram derajat pergerakannya.
RANCANG BANGUN TAS PUNGGUNG PINTAR UNTUK ANAK DENGAN LOAD CELL 5 KG, GPS DAN SMS BERBASIS ARDUINO MEGA 2560
Authors: Baihaqi Ahmad , Wisnu Djatmiko  , Muhammad Yusro
Published: February 2021

Bertujuan untuk Tujuan Penelitian ini adalah membuat sistem Tas Punggung yang dapat memantau berat tas punggung yang digunakan anak, memantau posisi GPS yang terdapat pada tas punggung, dan menginformasikan berat dan posisi tas punggung melalui komunikasi SMS. Hasil Penelitian Tas Punggung Pintar dapat direalisasikan dengan penggabungan sub-sistem yang berfungsi dengan baik, diantaranya : Arduino Mega 2560, Modul Buck Converter Adjustable IC LM2956, Sistem Display berbasis LCD & Keypad dan I2C, Sistem Pengukur Berat Bebasis Load Cell 5Kg-TAL220B dan ADC 24-bit HX711, Modul GPS Neo 6M-V2, Buzzer, RTC, Modul SIM 800L, dan Baterai Li-Po 3 sel. Sistem Tas Punggung Pintar dapat memberikan informasi berat isi tas dengan keakuratan pengukuran dengan akuratan mencapai ± 0,3 Kg, dapat memberikan informasi posisi GPS dengan tingkat rata-rata keakuratan mencapai 31,72 meter, dan dapat memberikan informasi kepada smartphone pengguna berat isi tas dan posisi GPS0 memalui komunikasi SMS dengan baik dengan daya tahan baterai mencapai 8 jam sebelum diisi ulang
ANALISIS JARINGAN AKSES INTERNET MENGGUNAKAN MIKROTIK ROUTER OS DI SMK TUNAS HARAPAN DENGAN OPTIMALISASI LOAD BALANCING MENGGUNAKAN PARAMETER QoS (Quality of Service)
Authors: Daud Muhammad Tulloh  , M. Ficky Duskarnaen  , Hamidillah Ajie
Published: February 2021

Penelitian ini bertujuan untuk mengetahui quality of service jaringan akses Internet dengan optimalisasi load balance pada Mikrotik Router OS di SMK Tunas Harapan Jakarta . Penelitian ini menggunakan metode penelitian rekayasa teknik dengan metode pengembangan sistem NDLC (Network Development Life Cycle), tahap implementasi sampai pada tahapan pengukuran meliputi throughput, jitter, packet loss, dan delay dengan melakukan transfer data dan monitoring streaming  dari laptop client ke server serta penerapan load balancing untuk optimalisasi dua ISP. Berdasarkan hasil akhir dari analisis dapat simpulkan bahwa kinerja parameter quality of service yaitu throughput, jitter, packet loss, dan delay pada jaringan akses Internet SMK Tunas Harapan termasuk dalam kategori Kurang Memuaskan menurut TIPHON.
Management of Missed Type-2 Monteggia Fracture Equivalent in a 9-Year-Old Child
Authors: Gopinathan Nirmal Raj , Rangasamy Karthick , Vatsya Pulak , Behera Prateek
Published: February 2021

Case:

A 9-year-old girl presented with a painful stiff elbow consequent to an injury she had sustained 4 months ago. The radiographs were suggestive of a type 2 Monteggia equivalent injury. She underwent an open reduction of the radial neck fracture and proximal ulna extension osteotomy to restore radiocapitellar alignment. At one-year follow-up, the child had a painless elbow with a good functional outcome.

Conclusion:

Monteggia lesions can be frequently missed and result in significant morbidity. Obtaining appropriate radiographs for a comprehensive understanding of the injury and proper surgical planning is important for achieving a good functional outcome in such injuries.
Primary Paraspinal Hydatid Cyst in a Patient Presenting with Low Back Pain
Authors: Raoulis Vasileios , Mitrousias Vasileios , Malahias Michael-Alexander , Stofas Anastasios , Fyllos Apostolos , Malizos Konstantinos N.
Published: February 2021

Case:

A 54-year-old man presented with low back pain and low-grade fever. Palpation revealed a focal mass of the lumbar region. Radiographs were normal, but magnetic resonance imaging demonstrated a multicystic mass at the level of L2-L4. The initial diagnosis of a hydatid cyst was confirmed after surgical excision.

Conclusion:

Although primary paraspinal hydatidosis is rare, physicians should be aware of it when dealing with patients suffering from low back pain combined with red-flag symptoms. Especially in rural regions or areas where populations live in close proximity to host animals, primary paraspinal hydatidosis should be included in the differential diagnosis.
GestaltMatcher: Overcoming the limits of rare disease matching using facial phenotypic descriptors
Authors: Krawitz Peter , Hsieh Tzung-Chien , Bar-Haim Aviram , Moosa Shahida , Ehmke Nadja , Gripp Karen , Pantel Jean Tori , Danyel Magdalena , Mensah Martin-Atta , Horn Denise , Fleischer Nicole , Bonini Guilherme , Schmid Alexander , Knaus Alexej , Sivalingam Sugirthan , Kamphans Tom , Ebstein Frédéric , Krüger Elke , KURY Sébastien , Bezieau Stephane , Schmidt Axel , Peters Sophia , Engels Hartmut , Mangold Elisabeth , Kreiß Martina , Cremer Kirsten , Perne Claudia , Betz Regina , Grundmann-Hauser Kathrin , Haack Tobias , Wagner Matias , Brunet T. , Bentzen Heidi Beate , Spielmann Malte , Schaaf Christian , Mundlos Stefan , Nöthen Markus
Published: February 2021

The majority of monogenic disorders cause craniofacial abnormalities with characteristic facial morphology. These disorders can be diagnosed more efficiently with the support of computer-aided next-generation phenotyping tools, such as DeepGestalt. These tools have learned to associate facial phenotypes with the underlying syndrome through training on thousands of patient photographs. However, this “supervised” approach means that diagnoses are only possible if they were part of the training set. To improve recognition of ultra-rare diseases, we created GestaltMatcher, which uses a deep convolutional neural network based on the DeepGestalt framework. We used photographs of 21,836 patients with 1,362 rare disorders to define a “Clinical Face Phenotype Space”. Distance between cases in the phenotype space defines syndromic similarity, allowing test patients to be matched to a molecular diagnosis even when the disorder was not included in the training set. Similarities among patients with previously unknown disease genes can also be detected. Therefore, in concert with mutation data, GestaltMatcher could accelerate the clinical diagnosis of patients with ultra-rare disorders and facial dysmorphism.
Clinical and epidemiological characteristics of carbapenem-resistant Klebsiella pneumoniae infections in a tertiary hospital in China
Authors: Cui Zhiwen , Wang Lirui , Chang Wei , Li Minghui , Li Yuexia , Feng Min
Published: February 2021

Background：The infections due to carbapenem-resistant Klebsiella pneumonia (CR-KP) have become an important problem. The aim of the study is to evaluate the clinical and epidemiological characteristics of CR-KP.
Results: The CR-KP infections overall mortality was 37.3%, and bloodstream infections mortality was 66.2%. Survival analysis revealed that there were statistically significant differences between bloodstream infection and pulmonary and drainage fluid infection. Hemopathy, age (>60 years), tumors, diabetes, septic shock, acute kidney injury and stroke were independent predictors associated with the 30-day mortality. Multivariate linear regression showed that survival time was negatively correlated with APACHE II score and SOFA score, while positively correlated with LYM. Chi-square test showed that antimicrobial regimen combined carbapenems, tigecycline with polymyxin B was superior the one combined carbapenems with polymyxin B. But there was not statistically significant difference between carbapenems plus tigecycline and carbapenems plus polymyxin B. Ceftazidime avibactam-based antimicrobial regimens also had no advantage over other therapeutic regimens.
Conclusions: Our study confirmed there is a high mortality rate in CR-KP infections, especially in the bloodstream infections. The outcome is greatly influenced by the patients’ clinical conditions. Antimicrobial regimen combined carbapenems, tigecycline with polymyxin B might be a better choice.
Using a GIS-based order weight Average (OWA) Methods to Predict Suitable Location for Artificial Recharge of Groundwater
Authors: Mokarram Marzieh , Negahban Saeed , Abdolali Ali , Ghasemi Mohammad Mehdi
Published: February 2021

The purpose of this study is to use the GIS-based analytic hierarchy process (AHP) and order weight average (OWA) to determine suitable locations for the artificial recharge of groundwater (ARG). Therefore, after preparing the fuzzy maps for each parameter, AHP method is used to pari comparison and determine the weight of each parameter. Then, using the OWA-AHP method based on different levels of confidence (different α values ​​), the weighting is done for each parameter to prepare the final land suitability maps with different risk levels. Also, the adaptive network-based fuzzy inference system (ANFIS) method is used to predict land suitability classes using input parameters. Then, using the Best subset regression method, the most important effective parameters for ARG are identified. The results of the Fuzzy-AHP method show that 27% of the area (in different parts) has good and very good conditions for ARG. The results of the combined OWA-AHP method show that, in case of low-level risk and no trade-off, more area is in very low class (80 %) while in case of the high level of risk and average trade-off, the highest area is in the very low class (27 %). The results of the ANFIS method show that fuzzy c–means (FCM) and sub-clustering methods have high accuracy to predict suitable places for ARG. The results of the best subset regression method show that slope, lithology, land use, and altitude with the lowest Cp values ​ (5.2) are effective parameters to determine ARG.
Association of central arterial blood pressure and left ventricular hypertrophy in patients with chronic kidney disease
Authors: Cai Ruyi , Shao Lina , Zhu Yifan , Zhang Jinshi , Liu Yueming , He Qiang
Published: February 2021

Aims: In the general population, central arterial blood pressure has proved to be more closely related to left ventricular hypertrophy than brachial arterial blood pressure. We aimed to investigate whether this relationship was true in patients with chronic kidney disease. Methods: In this retrospective study, we reviewed the medical records of 289 adult patients with chronic kidney disease from the Zhejiang Provincial People’s Hospital in Zhejiang, China. Demographic, echocardiographic, and brachial and central blood pressure parameters were retrieved from medical records. Central blood pressure was measured using the SphygmoCor® CvMS (AtCor, Australia) device and its corresponding software. Multivariate logistic regression analyses were performed to identify independent predictors of left ventricular hypertrophy. Receiver operating characteristic curves were used to determine the ability of central and brachial blood pressure to predict left ventricular hypertrophy.Results: The left ventricular mass index was positively associated with both central and brachial blood pressures. However, multiple logistic regression analysis demonstrated that a central pulse pressure ≥ 58 mm Hg was an independent risk factor for left ventricular hypertrophy (OR=5.597, 95%CI 2.363-13.259, P <0.001). Brachial pulse pressure is not superior to central pulse pressure in predicting left ventricular hypertrophy (AUC = 0.695, 95%CI 0.634-0.756, P < 0.001 vs. AUC = 0.687, 95%CI: 0.626 to 0.748, P < 0.001, respectively; P = 0.4824).Conclusions: Our results suggested that, similarly to the general population, central pulse pressure is a better parameter for predicting the occurrence of left ventricular hypertrophy in patients with chronic kidney disease.
Seed priming with Brassinosteroids alleviates Aluminum toxicity in rice via improving antioxidant defense system and suppressing aluminum uptake
Authors: Basit Farwa , Jiaxin Liu , Jianyu An , Min Chen , Can He , Xiaobo Zhu , Zhan Li , Jin Hu , yajing Guan
Published: February 2021

Brassinosteroids (BRs) are growth-promoting hormones that exhibit high biological activities inside numerous plant species. BRs play a protective role in plants against various stresses. In the present study, seed priming of 24-epibrassinolide (0.01µM) was used to demonstrate the mitigation effect of Aluminum (400µM) in rice plants. BRs application was found effective in control beside plants under aluminum (Al) toxicity. It enhanced seed germination energy, germination percentage as well as root length, shoots length, fresh and dry weight as well under the stressed condition as well as inside control (primed with BRs). Although, Aluminum toxicity induced reduction in seed growth parameters, also in photosynthetic pigments, increased MDA content, and H2O2 production by enhancing the activities of antioxidative enzymes such as ascorbate peroxidase, catalase, and peroxidase in both roots and shoots. These changes were noticed higher inside tolerant variety (YLY-689) as compared to sensitive cultivar (CY-927). Interestingly, 24-EBL copped the stress through decreasing MDA content as well as H2O2 production by more stimulating antioxidant activities to modulate the stress condition under Al stress. Gene expression analysis of SOD-Cu-Zn, SOD-Fe, CATa, CATb, APX02, and APX08 also supported the data related to antioxidant activities. These findings led us toward the conclusion that more induction of antioxidant activities with effective response toward other seed growth parameters with low uptake of Aluminum under 400µM Aluminum stress, 24-EBL was responsible for the mitigation of aluminum stress in rice seedlings.
Adaptive Hybrid Machine Learning Model For Forecasting The Step-Like Displacements of Reservoir Colluvial Landslides: A Case Study in The Three Gorges Reservoir Area, China
Authors: Linwei Li , Wu Yiping , Fasheng Miao , Yang Xue , Yepiao Huang
Published: February 2021

Constructing an accurate and stable displacement prediction model is essential to build a capable early warning system for landslide disasters. To overcome the drawbacks of previous displacement prediction models for step-like landslides, such as the incomplete or excessive decompositions of cumulative displacements and input factors and the redundancy or lack of input factors, we propose an adaptive hybrid machine learning model. This model is composed of three parts. First, candidate factors are proposed based on the macroscopic deformation response of landslides. Then, the landslide displacement and its candidate factors are adaptively decomposed into different displacement and factor components by applying optimized variational mode decomposition (OVMD). Second, in the gray wolf optimizer-based kernel extreme learning machine (GWO-KELM) model, the global sensitivity analysis (GSA) of the prediction results of different displacement components to each decomposed factor is analyzed based on the PAWN method. Then, the decomposed factors are reduced according to the GSA results. Third, based on the reduced factors, the optimal GWO-KELM models of the different displacement components are established to predict the displacement. Taking the Baishuihe landslide as an example, we used the raw data of three representative monitoring sites from June 2006 to December 2016 to verify the validity, accuracy, and stability of the model. The results indicate that the proposed hybrid model can effectively determine the displacement decomposition parameters. In addition, this model performed well over a three-year forecast with low model complexity.
Random compound mutagenesis breeding of Bacillus amyloliquefaciens X030 with high resistance to pathogenic bacteria on grass carp
Authors: Zhou Pengji , Huang Haiyan , Lu Jiaoyang , Zhu Zirong , Xie Junyan , Xia Liqiu , Luo Sisi , Zhou Kexuan , Chen Wenhui , Ding Xuezhi
Published: February 2021

Background: Bacillus amyloliquefaciens X030 (BaX030) was obtained by screening from peanut fields in Henan Province, China. It had broad-spectrum antibacterial activity against fish pathogens Aeromonas hydrophila and Aeromonas veronii. In order to improve its antibacterial effect, BaX030 was carried out the compound mutagenesis that atmospheric and room temperature plasma (ARTP) combined with nitrosoguanidine (NTG). Results: The result showed the yield of macrolactin A and oxydifficidin of the mutant N-11 were increased by 2.01 times and 3.68 times, respectively. Re-sequencing found that the corresponding 9th and 15th gene clusters had 4 and 6 SNP mutations, respectively, the 15th gene cluster also had 7 InDel mutations. Scanning electron microscopy observed that the N-11 became thin and long. The results of qRT-PCR indicated that feeding the N-11 can increase the expression of immune factors in the liver or kidney tissue of grass carp. It can also significantly reduce the mortality and the surface symptoms of grass carp that was infected by two pathogens through HE staining and protection experiments.Conclusion: This is the first report that after ARTP-NTG compound mutagenesis, a high-yielding strain of macrolactin A and oxydifficidin were increased by 2.01 times and 3.68 times compared with the original strain, respectively, which laid the foundation for elucidating its biological regulation, they had antibacterial effects on Aeromonas hydrophila and Aeromonas veronii. We combined re-sequencing to find the mutation sites of gene clusters and. The probiotic strain N-11 can quickly activate the immune protection mechanism of grass carp to resist pathogenic bacteria.
Immobilization of Thermoalkalophilic Esterase Onto Magnetic-Cornstarch Nanoparticle
Authors: Öz Yasin , Sürmeli Yusuf , Sanli-Mohamed Gulsah
Published: February 2021

The immobilization of the biocatalysts onto magnetic nanoparticles (MNPs) has been extensively applied since the external magnetic field facilitates the enzyme recovery from the reaction mixture. In the present study, glutaraldehyde-modified magnetite-cornstarch nanoparticles (MCNs) were successfully synthesized, elaborately characterized by ZetaSizer and surface-enhanced raman spectroscopy (SERS), and used for the immobilization of a thermoalkalophilic esterase from Geobacillus sp. The optimal immobilization conditions were obtained at 65oC, 2:3 molar ratios of Fe2+:Fe3+ and 1 g cornstarch resulted in approximately 90 nm magnetic particles in size. Also, immobilization yield and entrapment efficiency of the esterase were found as 74% and 82%, respectively. Scanning Electron Microscopy (SEM) micrographs showed that MCNs were uniform, spherical in shape, and well dispersed and esterase immobilized MCNs displayed similar morphology as free MCNs. The maximum activity of free and immobilized esterase was obtained at 80oC and pH 9. Immobilization onto glutaraldehyde-modified MCNs significantly enhanced the esterase thermostability. Additionally, the immobilized esterase kept its residual activity of 75% after three sequential cycles, suggesting that it has favorable operational stability.
Primary Intraocular Lymphoma in a Patient with Bilateral Epstein-Barr Virus Panuveitis: A Case Report
Authors: Hosseini Seyedeh Maryam , Abrishami Mojtaba , Barashki Elham , Zamani Ghodsieh
Published: February 2021

Purpose: Herein, we report a case of primary intraocular lymphoma (PIOL) with the first presentation of bilateral Epstein-Barr virus (EBV)-associated panuveitis and retinitis.Case presentation: A 69-year-old male was referred with a three-day history of blurred vision and pain and redness in his left eye following cataract surgery. Ophthalmic examination revealed panuveitis, vitritis, and necrotizing retinitis with retinal hemorrhage. A month later, the right eye was also involved. Initially, the clinical diagnosis of acute retinal necrosis was made based on clinical manifestation; however, the partial response to intravenous and intravitreal antiviral treatment in the left eye and involvement of the right eye resulted in further investigation of masquerade syndromes. Polymerase chain reaction-based analysis of vitreous sample was positive for EBV, and cytological evaluation was compatible with the diagnosis of B-cell lymphoma. A significant improvement was observed following serial intravitreal rituximab and methotrexate injections. The central nervous system and lungs were involved after 6 months, and the patient expired despite treatment with systemic chemotherapy. Conclusion: There may be an association between EBV panuveitis and primary intraocular B-cell lymphoma.
MWCNT-Coated Cotton Yarn Array For Piezoresistive Force and Bending Sensor Applications in Internet of Things Systems
Authors: Jeon Dae-Young , Park So Jeong , Lee Tae Yoon , Kim Gyu-Tae
Published: February 2021

Advanced sensors based on the Internet of Things (IoT) are bringing new technology and productivity paradigms to the era of the fourth industrial revolution. Here, piezoresistive force and bending sensors with good performance (sensitivity ≈ 0.3 kPa−1 and Δnormalized resistance/Δcurvature ≈ 1.5 cm) were fabricated by using perpendicularly aligned multi-walled (MW) carbon nanotube-coated yarn (CNT-CY) arrays, which were obtained from a simple dipping-and-drying method. Verification was performed using a proof-of-concept force sensor matrix with an Arduino open-source microcontroller. In addition, a force sensor combined with real-time data storage in Google Cloud was successfully demonstrated. This work provides important information for the development of a robust, low-cost, and easy-to-manufacture IoT platform with MWCNT-based composites as an active sensing material.
Analytical Quality By Design Methodology For Botanical Raw Material Analysis: A Case Study of Flavonoids in Genkwa Flos
Authors: Kim Min Kyoung , Park Sang Cheol , Park Geonha , Choi Eunjung , Ji Yura , Jang Young Pyo
Published: February 2021

The present study introduces a systematic approach using analytical quality by design (AQbD) methodology for the development of a qualified liquid chromatographic analytical method, which is a challenge in herbal medicinal products due to the intrinsic complex components of botanical sources. The ultra-high-performance liquid chromatography-photodiode array-mass spectrometry (UHPLC-PDA-MS) technique for eleven flavonoids in Genkwa Flos was utilized through the entire analytical processes, from the risk assessment study to the factor screening test, and finally in method optimization employing central composite design (CCD). In this approach, column temperature and mobile solvent slope were found to be critical method parameters (CMPs) and each of the eleven flavonoid peak’s resolution values were used as critical method attributes (CMAs) through data mining conversion formulas. An optimum chromatographic method in the design space was calculated by mathematical and response surface methodology (RSM). A validation study was also performed successfully for apigenin 7-O-glucuronide, apigenin, and genkwanin. In conclusion, the present design-based approach provide a systematic platform that can be effectively applied to ensure pharmaceutically qualified analytical data from complex natural products based botanical drug.
Influence of Spray Parameters on the Thickness, Hardness and Porosity of low-pressure Cold Sprayed WC-Ni Coatings
Authors: Jibran Wania , Hogan James , McDonald André
Published: February 2021

In this study, a 33 full factorial design methodology was used ­­to analyze the effects of spray parameters on the thickness, hardness, and surface porosity of low-pressure cold-sprayed WC-17Ni coatings. Three levels were selected for the spray parameters included in the design which were the powder feed rate (17.1 g/min, 21.1 g/min, and 23.7 g/min), gas temperature (475℃, 500℃, and 525℃), and the nozzle to substrate stand-off distance (3 mm, 5 mm, and 10 mm). It was found that the feed rate was the most significant parameter that affected the coating thickness. The surface porosity was most significantly affected by stand-off distance. The coating hardness was most influenced by the interaction between the feed rate and stand-off distance. An optimization study was then performed to maximize the coating thickness and hardness while minimizing the surface porosity. The optimal spray parameters (OSP) were found to be at a feed rate of 23.7 g/min, 500℃ for the carrier gas temperature, and 10 mm for the stand-off distance. The OSP yielded a coating that was 1.22 ± 0.06 mm thick, with a hardness of 364.5 ± 8.5 HV and porosity of 6.8 ± 0.6%. With a multi-parameter process, the system response is affected by both the variation in the individual parameters and the interaction of the parameters with each other. It was also concluded that the interaction between the parameters significantly affected the coating hardness. These results suggest that variation of the selected parameters produce statistically significant effects on the coating quality of WC-17Ni coatings using a low-pressure cold spray system.
FTIR, Optical, Electrical and Magnetic properties of Sm+3 doped Mg Nano Ferrites by Citrate-Gel Auto combustion method
Authors: Nakiraboina Venkatesh , Goud Shyam sunder , Nama Hari Kumar , Ravinder D , P Veera Somaiah
Published: February 2021

Sm, doped Mg nano ferrites with composition Mg Sm x Fe2 − x O4 (where X = 0.000, 0.025, 0.050, 0.075,0.1) were synthesized by citrate-gel auto-combustion method. The Samples were analyzed through various experimental techniques. The structural confirmation was done with the basic characterization techniques such as XRD (X-ray Powder Diffraction) and Fourier Transform Infrared (FTIR) spectroscopic analysis. To study the optical absorption behavior of the prepared ferrites, UV-visible spectral analysis was carried out. XRD analysis established the formation of single-phase cubic spinel structure of the materials. FTIR spectra has shown two absorption peaks that are characteristic of spinel nano ferrites. The dc electrical resistivities of the Sm doped Mg nano ferrites were studied by using two probe method at the temperature range of 200–500 °C. A plot of log (σT) vs inverse of temperature yields a curve which reveals a semiconducting nature of prepared nano ferrites. The Thermo Electric Power (TEP) studies of prepared samples carried out at high temperature (573K). The values of the Seebeck coefficient and curie temperature of Sm doped Mg nano ferrites were observed. The magnetization measurements were carried out by using Vibrating Sample Magnetometer (VSM).
Expanded Hemodialysis as Effective Alternative to On-Line Hemodiafiltration: A Randomized Mid-Term Clinical Trial
Authors: Hadad-Arrascue Fernando , Nilsson Lars-Göran , Rivera Angela S , Bernardo Angelito A , Romero Juan B Cabezuelo
Published: February 2021

BACKGROUND.
Hemodiafiltration (HDF) enhances middle molecule (MM) removal by convection and shows survival benefit compared to high-flux hemodialysis. Expanded hemodialysis (HDx), a novel therapy that effectively clears MM, uses medium cut-off (MCO) membrane without need for replacement fluid. We aimed to compare HDx to HDF prospectively in an open randomized controlled clinical study.
METHODS.
In a 24-week prospective study, HDF patients (age 18–80 yrs; on HDF > 3 months) were randomized to switch to HDx (N = 21) or continue HDF (N = 22). Pre- to post-dialysis reduction ratios (RR) and changes in pre-dialysis levels over time were evaluated for MMs and other clinical biomarkers. Use of erythropoiesis-stimulating agents (ESAs) were evaluated.
RESULTS.
HDx showed greater RR for YKL-40 while RR appeared similar between groups for beta2-microglobulin, FGF-23, and free light chains. Intra-dialytic changes in inflammatory biomarkers (IL-6, CRP, PTX3) did not differ between therapies. Changes from baseline to 12 and 24 weeks did not differ between groups for MMs, inflammatory markers, albumin, fibrinogen, hemoglobin, PTH, and phosphorus. Usage of erythropoiesis-stimulating agents tended to decrease in HDx arm while remaining stable in HDF arm.
CONCLUSIONS.
HDx showed equivalent removal of MMs versus high volume HDF. Greater RR of YKL-40, predictor of cardiovascular mortality in HD, was noted in HDx group. HDx appeared safe with similar clinical effectiveness as HDF. With fewer requirements and resource needs, HDx provides an attractive alternative to HDF. Further clinical studies are needed to confirm our results.
TRIAL REGISTRATION.
The study was registered as NCT03499691
Topological Analysis of Interaction Patterns in Cancer-Specific Gene Regulatory Network: Persistent Homology Approach
Authors: Masoomy Hosein , Askari Behrouz , Tajik Samin , Rizi Abbas K. , Jafari G. Reza
Published: February 2021

In this study, we investigated cancer cellular networks in the context of gene interactions and their associated patterns in order to recognize the structural features underlying this disease. We aim to propose that the quest of understanding cancer takes us beyond pairwise interactions between genes to a higher-order construction. We characterize the most prominent network deviations in the gene interaction patterns between cancer and normal samples that contribute to the complexity of this disease. What we hope is that through understanding these interaction patterns we will notice a deeper structure in the cancer network. This study uncovers the significant deviations that topological features in cancerous cells show from the healthy one, where the last stage of filtration confirms the importance of 1-dimensional holes (topological loops) in cancerous cells and 2-dimensional holes (topological voids) in healthy cells. In the small threshold region, the drop in the number of connected components of the cancer network, along with the rise in the number of loops and voids, all occurring at some smaller weight values compared to the normal case, reveals the cancerous network tendency to certain pathways.