bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Kompetensi dan Kepuasan Kerja terhadap Kinerja Pegawai pada Kantor Kecamatan Kuripan Kabupaten Barito Kuala
Authors: Anwar Rusihan , Rudiansyah Muhammad , Nurhikmah Nurhikmah
Published: April 2022

This study aims to determine the effect of competence and job satisfaction partially, and which of the two independent variables has the most dominant effect on the dependent variable at the Kuripan District Office, Barito Kuala Regency.This research is a quantitative method. The data used are primary data and secondary data. The research population was 23 people. Sampling research is a population study, the technique used is total sampling. Data collection techniques were carried out by distributing questionnaires. The data analysis technique used multiple linear regression using a computer application (Statistical Package for Social Science ties) SPSS-25. The results of the study concluded that the competence variable partially had no effect on employee performance at the Kuripan District Office, Barito Kuala Regency, and job satisfaction partially had a significant effect on employee performance at the Kuripan District Office, Barito Kuala Regency. on the performance of employees at the Kuripan District Office, Barito Kuala Regency.
Dominasi Keterampilan Wirausaha dan Inovasi Produk Terhadap Keberhasilan Pada UMKM Perak Celuk
Authors: Antari Ni Putu Devi , Basmantra Ida Nyoman , Eka Saputra Upayana Wiguna , Prasetya Bandem I Gede Adhi
Published: April 2022

Perkembangan usaha mikro, kecil, dan menengah (UMKM) ini banyak dipengaruhi oleh kemampuan dari seorang wirausahawan yang menekuni usahanya dalam bidang apapun. Keberhasilan usaha merupakan suatu tujuan bagi pengusaha sebagai capaian dari usaha mereka. Penelitian ini berfokus pada kewirausahaan yang bertujuan untuk mengetahui pengaruh atau dominasi Keterampilan Wirausaha dan Inovasi Produk terhadap Keberhasilan Usaha pada UMKM Perak Celuk. Fokus penelitian ini antara lain, untuk mengetahui pengaruh keterampilan wirausaha terhadap keberhasilan usaha, pengaruh inovasi produk terhadap keberhasilan usaha, pengaruh keterampilan wirausaha dan inovasi produk terhadap keberhasilan usaha. Populasi penelitian ini adalah seluruh UMKM Perak di Kab. Gianyar, dan sampel sebanyak 89 pengerajin perak di Desa Celuk dengan menggunakan metode purposive random sampling. Teknik pengumpulan data yang digunakan dalam penelitian ini yaitu metode survei dengan menyebar kuesioner. Dengan adanya penelitian ini diharapkan dapat menambah serta memperluas wawasan pembaca mengenai pengaruh keterampilan kewirausahaan dan inovasi produk terhadap keberhasilan usaha khususnya UMKM Perak di Desa Celuk. Penelitian ini menemukan bahwa keberhasilan usaha serta penggabungan keberhasilan wirausaha dan inovasi produk berpengaruh positif terhadap keberhasilan usaha. Sedangkan inovasi produk tidak berpengaruh positif terhadap keberhasilan usaha.
MODEL ARSITEKTUR POHON KAWASAN JALUR HIJAU DI KECAMATAN CICALENGKA KABUPATEN BANDUNG
Authors: Rosalina Novia
Published: April 2022

The existence of green line is very important for people's lives, because being planted in this area is very useful for reducing urban pollution that is built from vehicles and factories equipped with gas containing solid particles. One of component for green line is tree, because it’s have branching that’s reducing urban pollution. The branching architecture is a morphological representation of a particular phase of a series of tree growth series, real and observable at all times. The object of research is a tree census was carried out on Jl. National II / Jl. Bypass of the Cicalengka green line area then describe of model architecture. The method of research by sensus for numbering species of tree and identify of tree architecture model using book by F. Halle & R.A.A. Oldeman, namely: An Essay on The Architecture and Dynamics of Growth of Tropical Trees. The results of reseach are 946 trees that grow on Jl. Nasional III in the Cicalengka green line area. There are 15 tree species found 4 tree architectural models namely troll, rauh, aubreville, and champagnat.
DISTRIBUSI DAN PENGGUNAAN HABITAT EMPAT SPESIES FELIDAE DI TAMAN NASIONAL BUKIT BARISAN SELATAN
Authors: Supartono Toto , Nasihin Iing , Tawaqal Feizal
Published: April 2022

The polulation of Cat Family (Felidae) in Southeast Asia has declined in nature owing to its lost habitat, fragmentation one and massive hunting. Meanwhile, the research of Asiatic Golden Cats, Sunda Clouded  Leopards, Marbled Cats, and Asian Leopard Cats is not much conducted. This research aimed to find out their distribution and habitat use in Southern Bukit Barisan National Park (BBSNP). The data intake employed Camera Trap, then analyzed by occupancy model with single season and single species applying R-software. It was found that  Asiatic Golden Cat Occupancy Model yielded 0.75 in Intensive Protection Zone or Zona Perlindungan Intensive (IPZ) and 0.4 occupancy value in northen parts of  Sourthern Bukit Barisan National Park (BBSNP). Furthermore, its Sunda Clouded Leopards resulted in 0.50 in IPZ and 0.42 occupancy value in northen parts of BBSNP. Its Asian Leopard Cats was 0.16 occupancy value in IPZ  and unexecuted occupancy model in northen parts of BBSNP due to extremly low detection.
SEBARAN DAN KELIMPAHAN KUKANG JAWA (Nyticebus javanicus) DI TAMAN WISATA ALAM GUNUNG TAMPOMAS
Authors: Purwanto Asep , Rosyidin Hilman
Published: April 2022

The observation of distribution and abundance of Javan slow loris (Nycticebus javanivus) was carried out in Sumedang district area (West Java), which includes at TWA Gunung Tampomas. The objective of the research is to investigate the distribution and abundance of Javan slow loris at side and outside of protected forest in support the conservation management of slow loris. Observation location was between protected forest and agricultural area an altitude of 600 to 900 m above sea level. The result only on the three lines transect Javan Slow loris were found with total 11 individual. The population is less than the population outside the site research. Twenty-six individuals of Javan slow loris were found in community’s plantation which vegetation dominated by bamboo trees and agriculture plantation.
IDENTIFIKASI PERMASALAHAN DAN STRATEGI PENGELOLAAN TAMAN HUTAN RAYA NURAKSA
Authors: Syaputra Maiser
Published: April 2022

Tahura is a nature conservation area with a purpose to collecting natural or non-native plants and or animals, native and or non-native species, which are utilized for research, science, education, supporting cultivation, culture, tourism and recreation. As a conservation area whose territory is directly adjacent to the community, Nuraksa Forest Park is a source of economy and life for the surrounding community so that it can be said that there is community dependence on land in the area. This is a challenge in managing the area. In an effort to provide management direction so that the functions and benefits that have been regulated in the legislation and the achievement of the goals that have been formulated can be achieved, the perceived need for activities to identify problems and management strategies of Nuraksa Forest Park. The research was carried out through a series of activities, which consisted of literature studies, interviews and field surveys. The results of the SWOT analysis of the management of Nuraksa Forest Park are in quadrant III. This shows that Nuraksa Forest Park faces enormous opportunities, but on the other hand faces several internal obstacles / weaknesses. The strategy that must be implemented is to minimize the internal problems of the institution so that it can seize better opportunities.
SELEKSI CALON POHON PLUS KILEMO (Litsea cubeba) DI GUNUNG LEMO KABUPATEN CIANJUR JAWA BARAT
Authors: Darliana Ina , Nurmawanti Elis
Published: April 2022

Kilemo (Litsea cubeba) is a forest plant that has high economic value such as essential oils which can be used as raw materials for various biopharmaceutical industries such as soap, perfume, medicines, and aromatherapy. This potential has not been developed by the surrounding community as a commodity for industrial raw materials due to public ignorance in cultivating, besides the difficulty of getting seeda from kilemo itself is another reason for residents to cultivate these plants. The object of research is to identify prospective of trees plus of kilemo. The selction of plus trees was carried out using a purposive sampling system by placing units using random start method and selecting the tree heigt and diameter according to the plus tree scoring table. There were 29 prospective trees plus of kilemo identified according to their phenotypic appearance with the following characteristics: the average total tree heigt was more than 10 m (20-36 m), the branch-free height was realtively low, and the largest diameter was 32 cm. In addition, it was also found to be fruiting and flowering at 72,41%, only 17,24% to bear fruit and 10,34% to flower.
KELIMPAHAN VEGETASI POHON PAKAN LUTUNG JAWA DI TAMAN WISATA ALAM PANANJUNG PANGANDARAN
Authors: Ramdhani Eghi
Published: April 2022

The existence of Javan langurs is currently increasingly threatened due to several factors, such as deforestation which causes reduced availability of forage. Taman Wisata Alam (TWA) Pananjung Pangandaran is one of the habitats of Javan langurs and has an abundance of tree diversity and does not yet have data on the abundance of feed types. The objective of research was to determine the abundance of Javan langur food trees in TWA Pananjung Pangandaran. The method used is by modifying the status and abundance category based on the results of vegetation analysis. Javan langur food trees species in TWA Pananjung Pangandaran consist of 30 species from 28 families. The abundance of Javan langur feed in TWA Pananjung Pangandaran at the pole level vegetation there were 3 types which included the category of very much abundance, category of abundance there were 3 types, category of low abundance there were 3 types, and category of very little abundance was found in 2 species. Abundance at the tree level consists of a very large category of 6 species, a large category consisting of 6 species, a low category consisting of 6 species, and a very low category consisting of 5 species.
A Scale Proposal for COVID-19-related Social Stigmatization: The Psychometric Properties of the COVID-19 Stigmatization Scale
Authors: YETKİN Aysegul , YAVUZ Yasar , KAPICI Yaşar , EGELİ Aslı , TEKİN Atilla , KARAMUSTAFALIOĞLU Oğuz
Published: April 2022

Background: Social stigmatization is one of the most important results of the COVID-19 pandemic. The aim of the present study is to develop a measurement tool for assessing COVID-19-related stigma.
Materials and Methods: The sample of the study consisted of 324 participants who were formerly diagnosed with COVID-19. Measurement regarding the validity of the COVID-19 Stigmatization Scale was evaluated with exploratory analysis.
Results: Females accounted for 50.3% (n = 163) of the participants, and the mean age of the participants was 35.35  11.23 . The internal consistency coefficient of the scale was 0.95. The internal consistency coefficients of the subscales were .92 for “anticipatory anxiety”, .90 for “external stigmatization,” .89 for “negative self-image,” .84 for “contagion anxiety,” .90 for “disclosure anxiety,” and .87 for “internal stigmatization.” The total variance explained by the scale was 61.96%.
Conclusions: The findings indicated that the COVID-19 Stigmatization Scale, consisting of 44 items in six subscales, is a valid measurement tool for COVID-19 related social stigma.
The Influence of Spirituality Workplace to Motivation, Job Satisfaction and Organizational Commitment
Authors: Epafras Fanggidae Rolland
Published: April 2022

Objective - Competition between organizations, demanded that any organization can provide quality service and quality for stakeholders. One important aspect which will also determine the achievement of college performance, namely the lecturers. The relationship between the individual commitment to the organization shows the relationship between motivation and job satisfaction can improve the quality of university. While a basic understanding of the meaning of work is closely related to spiritual values that are owned by the individual in his work. This awareness can also be pursued by university through the fulfilment of the needs of both psychological and spiritual faculty, thus creating a conducive work environment. This research is descriptive, so that verification and explanatory research method used was a survey of 320 professors in the region of East Nusa Tenggara, Indonesia.

Methodology/Technique - Tests in this study using structural equation modeling (SEM) based variants or components, namely the Analysis of Moment Structure (AMOS).

Findings - The test results showed that (1) Spirituality in the workplace has an influence on the motivation. (2) Spirituality in the workplace does not have an influence on job satisfaction. (3) Spirituality in the workplace has an influence on organizational commitment. Based on the research results obtained by this research

Novelty - Novelty where spirituality in the workplace and motivation generate positive motivation for the members of the organization. This shows that the spiritual values inherent in individuals produce more meaning to work, where the work is not for material gain alone.

Type of Paper: Empirical

Keywords: Workplace in the spirituality; Spirituality Workplace; Motivation; Job Satisfaction; Organizational commitment.

JEL Classification: J24, J28.
Model of Strengthening the Entrepreneurship Character through Entrepreneurship Commitment
Authors: Budiningsih Iffah , Ahmad Masduki , Sukamto Heri
Published: April 2022

Objective - This study aims to determine the relationship between entrepreneurship character with entrepreneurship commitment.

Methodology/Technique - 87 randomly selected undergraduate students studying Business Economics at the As-Syafi'iyah Islamic University Jakarta are surveyed and the data is analyzed using descriptive analysis, correlation and regression methods.

Findings - The results show that entrepreneurship commitment has a strong positive influence on entrepreneurship character (0.66). Entrepreneurship commitment is therefore an important instrument to strengthen the character of entrepreneurship. Further, strengthening the character of entrepreneurship can be predicted by entrepreneurship commitment using a simple regression model: Ŷ = 0,658 + 0,823 X.

Novelty - In addition, the contribution of entrepreneurship commitment towards the formation of character of entrepreneurship is 44%, with factors such as discipline, perseverance, honesty, fighting power etc. contributing the remaining 56%.

Type of Paper: Empirical.

Keywords: Entrepreneurship; Character; Entrepreneurship Commitment.

JEL Classification: M10, M16, M19.
Non-linear Effect of Debt on the Economic Performance of Trans-Pacific Partnership Countries
Authors: Yoke Chong Choy , Ee Yvonne Lee Lean
Published: April 2022

Objective - The formation of the Trans-Pacific Partnership (TPP) without the United States has raised many concerns in terms of the possibility of its success. The economic growth of the remaining 11 partner countries is important for the success of the formation of the TPP. Although economic performance depends on certain crucial indicators including debt, the effect of debt on the economic performance among the TPP partner countries remains ambiguous. Methodology/Technique - As a result, this study investigates the nonlinear effect of debt on the economic performance of these partner countries (excluding Brunei and Vietnam) as a whole. In addition, the optimal level of debt is proposed as a means to control the level of debt for sustainable economic growth. Unbalanced panel data of the annual public debt-to-Gross Domestic Product ratio (measured as a percentage of GDP) and real GDP per capita from 1984 to 2015 was collected. Through panel analysis, this study reports an inverted U-shaped relationship between debt and economic performance. Findings - The threshold debt level was identified at 58.02% of GDP. This non-linear relationship means that increasing debt has a positive impact on economic performance before reaching 58.02% of GDP, and an inverse impact on economic performance occurs after this threshold debt level. However, the average debt reveals that the partnership as a whole experiences the reverse effect of debt on growth during this period. Novelty – This study highlights the need for prudent indebtedness policies to ensure continuing trade integration. Type of Paper - Empirical. Keywords: Debt; Growth; Nonlinear; Threshold; TPP Countries. JEL Classification: G10, G11, G19.
Leadership Development in the Flow of Work: Leveraging Technology to Accelerate Learning
Authors: Young Stephen , Diaz Jessica , De Coutere Bert , Downs Holly
Published: April 2022

"A recent industry trend survey of CEOs found that only 11% of organizations report having a strong enough bench to fill leadership roles (Rhyne, 2021). As such, effective leadership development is an imperative for any high-performing organization. Rather than focusing time, money, and energy on only a small subset of “high-potential” employees, organizations can realize the full potential of their entire workforce by providing tech-enabled leadership development to leaders at all levels. This paper shares the following insights for Chief Learning Officers interested in leveraging evidence-based practices to accelerate leader development at scale and unlock the collective potential of their workforce: • A brief overview of why we need new ways to develop leaders and a high-level description of the new digital assessment and development tools that meet individuals where they are – offering a highly personalized approach to development in-the-flow of work. • A review of eight research-based learning practices that provide a foundation for leveraging technology to make in-the-flow leadership development better, faster, and more accessible to leaders at all levels. For every learning practice, we provide implementation tips and discuss illustrative example tools. • We conclude with a discussion around the strategic use of the eight learning practices for enabling better organization-wide development outcomes. "
Analysis of Mortality from COVID-19 in the Atyrau Region during the Outbreak in 2020
Authors: Sagatkali AS , Tussupkaliyeva KSh , Urazaуeva ST , Urazayeva AB
Published: April 2022

Introduction: Among the population of the regions of Kazakhstan, deaths from COVID-19 were more frequent in the regions with high incidence rates. One of these regions was the Atyrau Region, which ranked fifth in the number of the infected in the republic in June 2020.
Objective: To analyze deaths from COVID-19 in the Atyrau Region during the outbreak in 2020.
Materials and methods: We analyzed medical histories of 53 inpatients who died of SARS-CoV-2 infection from June 1 to July 31, 2020 in the Atyrau Region.
Results: The main factors contributing to the lethal outcome included concomitant diseases, such as ischemic heart disease, diabetes mellitus, arterial hypertension, and obesity, which were diagnozed in 37 patients. The mortality rate was higher in
elderly cases aged 61–70 years.
Discussion: Arterial hypertension was found to be the most prevalent comorbidity that worsened disease severity in COVID-19. Our study demonstrated that the relationship between hypertension and mortality in patients with the novel coronavirus disease largely reflected their elderly age.
Conclusions: The mortality data in the Atyrau Region showed deaths from COVID-19 during the period of high incidence of the disease in the summer of 2020 (6,069 cases were registered only in July 2020) potentially attributed to comorbidies, elderly
age, delays in seeking medical help, a severe course of the disease with > 50 % lung involvement, lack of observation and outpatient treatment at the level of primary health care.
Methodological Approaches to Processing Laboratory Results of Ambient Air Quality Monitoring for the Purposes of Human Health Risk Assessment
Authors: Ovchinnikova EL , Nikitin SV , Kolchin AS , Novikova YuA , Fedorov VN , Kriga AS , Plotnikova OV , Cherkashina MN , Vinokurova IG , Shmakova NP
Published: April 2022

Introduction: The problem of practical application of recommended methods of processing ambient air pollutant concentra­ tions below the limit of detection in chemical analysis raises uncertainties in human health risk assessment. The Federal Clean Air Project has increased legal significance of the latter and the relevance of interdepartmental cooperation in air monitoring activities.
Objective: To review methodological approaches to handling ambient air quality test results and to develop proposals for uncertainty reduction in human health risk assessment.
Materials and methods: We analyzed ways of dealing with values of ambient air pollutant concentrations lying below the limit of quantification of various analytical chemistry methods proposed by the European Bureau for Integrated Pollution Preven­ tion and Control and Russian researchers. A human (population) health risk assessment was conducted based on air quality parameters obtained in 2020 within environmental and public health monitoring in the city of Omsk using average concentrations of airborne pollutants measured by different techniques in accordance with national guidelines R 2.1.10.1920–04.
Results: Different approaches to processing air quality test results produced different average pollutant concentrations accounting for health risk values ranging from the acceptable level to that of concern. Our estimates showed that certain tech­ niques of quantitative chemical analysis of priority air contaminants are inappropriate for the purposes of human health risk assessment. Photometry, for instance, was found unacceptable for measuring ambient concentrations of formaldehyde to assess carcinogenic risks due to unreasonable overestimation of the latter.
Conclusions: We have proposed criteria for selecting appropriate methods of air quality testing based on estimated values of the lower limit of quantification of chemicals and for optimizing procedures of processing test results for correct assessment of
health risks and harmonization of interdepartmental approaches.
Traditional Lifestyle of the Indigenous Population of the Khabarovsk Krai
as a Factor Determining the Spread of Helminth Infections
Authors: Dragomeretskaya AG , Bebenina LA , Trotsenko OE , Gaer SI
Published: April 2022

Introduction: Supporting health and wellbeing of indigenous small-numbered peoples of the North is one of the priorities of the regional policy in the Khabarovsk Krai. The centuries-long adaptation of the population to local conditions has created a unique system of the traditional use of natural resources and the most efficient forms and types of households. Despite all globalization processes, fishing, hunting and gathering remain essential elements of the lifestyle of northern indigenous peoples. Against the natural background, specific features of their behavior and nutrition create optimal conditions for helminth life cycles and intense transmission of endemic helminth infections.
Objective: To assess effects of the traditional lifestyle of the indigenous population of the Khabarovsk Krai as a factor responsible for the spread of larval helminthiasis and endemic trematode infections.
Materials and methods: In 2010–2020, questionnaire-based surveys were conducted and feces samples were collected from Nanai people in the villages of Dada, Sikachi-Alyan, Sinda, and Naikhin and from Udege people in the villages of Gvasyugi and Arsenyevo during expeditions.
Results: Endemic trematode eggs were detected in stool samples from all the villages. Clonorchis sinensis eggs were detected in the samples from Dada, Sinda, and Sikachi-Alyan, while Nanophyetus salmincola schikhobalowi eggs were found in the dwellers of Arsenyevo and Gvasyugi. Metagonimus spp. eggs were also detected in isolated cases. The results of sero-epidemiological survey indicate a high frequency of contacts with Toxocara roundworms in all areas and with tapeworms of the Echinococcus type in the traditional villages located in forest areas.
Conclusion: Original lifestyle and dietary habits of indigenous peoples in the Khabarovsk Krai pose a high risk of trematode infections (clonorchiasis, nanophietiasis, metagonimiasis) and larval helminthiasis (echinococcosis, toxocarosis). In combination with poor awareness of the population of appropriate preventive measures, this risk contributes to high incidence and prevalence rates of helminthiases in all surveyed national villages.
Methodological aspects of the detection of minimal residual disease in patients with acute leukemia
Authors: Galtseva I. V. , Smirnova S. Y. , Parovichnikova E. N.
Published: April 2022

Introduction. The study of minimal residual disease (MRD) has become an integral part of various treatment protocols for acute leukemia. Methods of polymerase chain reaction (PCR) and multicolor fl ow cytometry (MFC) are most widely used to assess MRD.

Aim — to characterize the main technologies for the detection of residual tumor cells in acute leukemia

Main findings. Various approaches for detecting MRD are described: PCR with patient-specifi c primers for rearranged genes of immunoglobulin and/or T-cell receptors, reverse transcription PCR for detecting chimeric transcripts and assessing the expression of overexpressed genes, as well as the basics of detecting MRD by MFC. Each of these approaches has its own advantages, disadvantages, and limitations of use.
Blood groups and acute respiratory viral infection COVID-19
Authors: Zubareva L. M. , Donskov S. I.
Published: April 2022

Introduction. Polysaccharides, glycoproteins and glycolipids, which determine the group-specifi c properties of human blood, are both structural elements of the whole organism and determine its predisposition to certain somatic and infectious diseases. Thus, the blood group of an individual can be used among other markers and/or prognostic factors of the occurrence and course of certain groups of diseases.

Aim — analysis of literature sources characterizing the relationship of blood groups with COVID-19 ARVI, as well as the mechanisms underlying this relationship.

Main findings. The Oaß(I) phenotype ensures an individual’s resistance to infection with the SARS-CoV-2 virus and allows for a relatively mild course of the disease. The Aß (II) phenotype is a risk factor for the development of COVID-19 ARVI, in its severe course, the occurrence of complications and increased mortality. An additional component of protection in the form of a negative Rh-affi liation of the infected person is not excluded. The protective properties of the Oaß(I) phenotype are associated with the absence of polysaccharide A in an individual and the presence of anti-A antibodies. The increased risk of COVID-19 ARVI among Aß (II) individuals is due to the large polymorphism of polysaccharide A in the environment and the lack of natural immunity to other forms of polysaccharide A in this group.
Use of eltrombopag in treatment programs for patients with aplastic anemia
Authors: Mikhailova E. A. , Luchkin A. V. , Abramova A. V. , Fidarova Z. T. , Troitskaya V. V. , Dvirnyk V. N. , Galtseva I. V. , Kovrigina A. M. , Alimova G. A. , Obukhova T. N. , Abramova T. V. , Parovichnikova E. N. , Savchenko V. G.
Published: April 2022

Introduction. The use of thrombopoietin receptor agonists, especially eltrombopag, in the treatment of aplastic anemia (AA) patients who did not respond to the previous immunosuppressive therapy (IST), is accompanied by the development of a hematological response in 40–60 % of patients.

Aim — to study the effi cacy of using eltrombopag in treatment programs for AA patients refractory to previous IST.

Methods. The study included 20  AA patients who were treated at the National Research Center for Hematology from 2015 to 2020. These patients did not respond to the conducted IST (ATG + CsA). Eltrombopag was administered at a dose of 150 mg/day. The results of treatment were assessed at 3 and 6 months: the achievement of hematological improvement, partial and complete remission, as well as the identifi cation of possible clonal evolution were determined.

Results. Eleven out of 20 (55 %) patients responded to treatment: 2 patients developed hematological improvement, 6 patients — partial remission, 3 patients — complete remission. All 11 patients responded to treatment within 12 months from the start of eltrombopag, but further positive dynamics of hematological parameters are possible. The median duration of treatment with eltrombopag was 11 (1–48) months. Most of the patients were treated with eltrombopag in combination with CsA. The duration of the course of treatment with eltrombopag depended on the response received (stable hematological improvement, remission, as well as the detection of clonal evolution) or its absence and the need for ATG or BMT. An aberrant karyotype was found in 2 AA patients who received eltrombopag: in one patient monosomy of chromosome 7 was detected 1 month after the start of treatment, in another patient, 37 months later, a clone with a derivative of chromosome 16 from t(1;16) and subclone with complex disorders of the karyotype without signs of myelodysplasia in the bone marrow.

Conclusion. The inclusion of the TPO receptor agonist eltrombopag in the treatment program for AA patients allows for a stable hematological response and remission of AA for patients who have not responded to IST. The effectiveness of eltrombopag is determined by adherence to the treatment algorithm, the optimal duration of the course, and the dose of the drug used. There is still a need for long-term observation of the patient and control morphological and cytogenetic studies.
Thrombotic thrombocytopenic purpura in pregnancy. Giving birth or not giving birth, that is the question
Authors: Galstyan G. M. , Shmakov R. G. , Klebanova Е. Е. , Troitskaya V. V. , Dvirnyk V. N. , Surin V. L. , Pshenichnikova O. S. , Pozdnyakova Yu. M. , Polushkina E. S. , Gaponova T. V. , Mamleeva S. Yu. , Pyregov A. V. , Rogachevskiy О. V. , Sysoeva E. P. , Tsvetaeva N. V.
Published: April 2022

Introduction. Pregnancy is one of the most frequent triggers of congenital and acquired forms of thrombotic thrombocytopenic purpura (TTP).

Aim — to develop tactics for the treatment of pregnant women with TTP.

Results. TTP was associated with pregnancy in 55.5 % of all cases of TTP in women. In 5 pregnancies in which the diagnosis of TTP was known before pregnancy, or established in the early stages, TTP was treated throughout the pregnancy. In the congenital form, plasma transfusions were performed once every two weeks until the  20th  week of pregnancy, or  weekly, if thrombocytopenia < 150 × 109 /L persisted. Plasma transfusions were performed weekly after the 20th week with the goal of achieving clinical remission. With acquired TTP, glucocorticosteroids and plasma exchanges were used as  treatment, in 1 case — rituximab, with the aim of achieving a clinical remission and an ADAMTS13 activity > 20 %. In this group of pregnant women, 1 caesarean section was performed and there were 4 cases of vaginal deliveries, with a total of 5 children being born with an average Apgar score of 7.5. In 7 pregnancies in which TTP fi rst manifested late, leading to a delayed diagnosis, preventive and curative measures were not carried out before delivery. In this group there were 2 abortions of pregnancy, 5 surgical deliveries, 3 cases of preeclampsia, 3 acute cerebral circulatory disorders, 1 intraabdominal bleeding, 1 case of acute renal failure, with two women undergoing mechanical ventilation. There was 1 case of antenatal fetal death, with a total of 4 children being born, who were assessed on the Apgar scale with an average of 5 points.

Conclusion. Timely diagnosis as well as ongoing therapeutic and preventive measures help to avoid complications during childbirth in pregnant women with TTP.
Chimeric antigen receptor T-cell therapy in adult patients with B-cell lymphoproliferative diseases
Authors: Gavrilina O. A. , Galstyan G. M. , Shchekina A. E. , Kotova E. S. , Maschan M. A. , Troitskaya V. V. , Koroleva D. A. , Zvonkov E. E. , Fidarova Z. T. , Vasilyeva V. A. , Parovichnikova E. N.
Published: April 2022

Introduction. The introduction of chimeric antigen receptor (CAR) T-cell therapy is a promising treatment of patients with relapsed or refractory (R/R) B-cell lymphoproliferative diseases (LPDs).

Aim — to present the results of CAR-T-cell therapy of 6 adult patients with B-cell LPDs.

Materials and methods. This is a pilot study conducted in adult patients with R/R or persistent minimal residual disease B-cell LPDs treated with CAR-T-cells. The study was approved by a local ethical committee of National Research Center for Hematology. Patients did not have alternative options for effective and safe treatment. All patients signed an informed consent. All patients were lymphodeplated with fl udarabine and cyclophosphamide for 4 days before the introduction of CAR-T-lymphocytes. Cytokine release syndrome (CRS) was prevented by tocilizumab on the day of CAR-T-cell administration. The effi cacy and safety of CAR-T-cell therapy was evaluated.

Results. From 01.01.2020 to 01.01.2022, 10 CAR-T-cell infusions were performed for 6 adult patients (age 19–68 years, median — 32 years) with B-cell LPDs: 4 — R/R B-acute lymphoblastic leukemia, 1 — R/R diffuse large B-cell lymphoma, 1 — persistence of MRD in mantle cell lymphoma. In all patients with a R/R, median — 4 (2–5) lines of chemotherapy and/ or immunotherapy were performed before CAR-T-cell therapy. CD19 CAR-T-cells received 3 patients, CD19/CD22 CAR-Tcells — 2 patients, CD19 and CD20 CAR-T-cells received 1 patient. Autologous CAR-T-cells received 4 (66 %) patients, allogeneic CAR-T-cells received 1 patient, and one patient had two CAR-T-cell administrations — 1 autologous and 1 allogeneic. The median number of CAR-T-cells was 0.5 × 106 /kg (from 0.1 × 106 /kg to 3 × 106 /kg). In 7 (87.5 %) of the 8 cases after CAR-T-cell administration, overall response to therapy (complete or partial remission) was achieved, and complete remission was achieved in 6 (75 %) cases. Side effects were noted after 8 of 10 CAR-T-cell transfusions: CRS in 40 % (CRS 1 — 10 %, CRS 2 — 20 %, CRS 3 — 10 %), ICANS in 10 %, tumor lysis syndrome in 20 %, multi-organ dysfunction syndrome in 10 %.  There were no lethal complications due to CAR-T-cell administrations. The median follow-up period was 6 (1–16) months. Of the 6 patients, 2 (33 %) died from relapses and progression of LPD. One (17 %) patient died in complete remission from infectious complications. Three (50 %) patients are observed till now. The median time of CAR-T-cell circulation was 33 (6– 60) days.

Conclusion. CAR-T-cell therapy is a promising treatment for R/R B-cell LPDs and LPDs with persistence of MRD after cytoreductive therapy. This type of therapy requires a multidisciplinary approach.
Single-shot chirped pulse digital holography for observing the propagation of ultrafast optical pulses in liquid
Authors: Karasawa Naoki , Ishikawa Tomohiro , Sugo Rika
Published: April 2022

The propagation of intense ultrafast optical pulses in liquid was observed using single-shot chirped pulse digital holography for measuring the sequence of ultrafast optical wavefronts. In this method, two non-collinear ultrafast object pulses and a chirped reference pulse were interfered to record the digital hologram of optical wavefronts at two different times. The phase difference images of the propagation of intense optical pulses in water as well as carbon disulfide separated by 0.67 ps were obtained and the densities of generated plasma were estimated.
Low-pressure acidic ammonothermal growth of 2-inch-diameter nearly bowing-free bulk GaN crystals
Authors: Kurimoto Kouhei , Bao Quanxi , Mikawa Yutaka , Shima Kohei , Ishiguro Toru , Chichibu Shigefusa F.
Published: April 2022

Seeded growth of 2-inch-diameter GaN crystals via low-pressure (∼100 MPa) acidic ammonothermal method is demonstrated. Nearly bowing- and mosaic-free GaN crystals exhibiting full-width at half-maximum values for the 0002 X-ray rocking curves below 20 arcsec were achieved on high lattice coherency c-plane SCAATTM seeds with gross dislocation densities in the order of 104 cm−2. The photoluminescence spectra of the grown crystals exhibited a predominant near-band-edge emission at 295 K, of which intensity was one order of magnitude higher than the characteristic deep-state emission bands. A nearly bowing-free 60 mm × 60 mm c-plane GaN crystal was eventually obtained.
Gatepass Generation and Management System
Authors: Pekam Ganesh , Chalikwar Shrinivas , Alane Abhijit , Pekam Pranav , Sarode Padmavati
Published: April 2022

GatePass Generation and
Management System is a software mobile application. The Project “Gate Pass
Generation and Management System” is itself tells that is to generate gate pass
for regular and for visitor, students, teachers, employees and customers. It
maintains the record of visitor and various activities of the user in the system.
This can be used to replace our manual visitor process and then give them
passes and management process through our system. Gate pass Generation and
Management system is available for use of various visitor, students, teachers, employees
and customers and it is easy to use and manage. This system is defined as a
security system. It’s main aim to secure colleges from outside visitors, the
department and the various working institute. Gate pass Generation and
management system help the organization as well as a visitor to manage the Gate
passes through QR code generator in easy way
The intelligentsia and the authorities of Ukraine in the first half 20s of the twentieth century
Authors: Sheyko Vasyl
Published: April 2022

The aim of this paper is to analyze the processes of evolution of the views of the old intelligentsia concerning the authorities and the working-class and peasants in the early 20s of the 20th century. Special attention is paid to the role of professional unions in establishing business cooperation of the various groups of the old intelligentsia with the Soviet officials of the Bolshevik regime in Ukraine.
Relevance. The article analyzes the little-investigated processes of transformation of the worldview attitudes of the old intelligentsia of Ukraine regarding the Soviet regime and its economic and cultural policy, its attitude to the old intelligentsia. The author studies the various aspects of professional unions' activities in establishing business cooperation of the old intelligentsia with the Bolsheviks authorities in Ukraine.
Problem statement. Currently Ukraine appropriately marks the 100th anniversary of the events of the Ukrainian Revolution of 1917—1921. That is why the study of diversification of the views of the old intelligentsia regarding the Soviet regime in Ukraine in the early 1920s continues to be relevant. The Bolshevik regime in Ukraine was fated to win over the old intelligentsia. The further fate of this regime depended on this.
The research methodology. In this study the author uses culturological principles and methods, which make it possible to examine the complicated issues of the relationships between the authorities and the old intelligentsia in Ukraine in the early 1920s. The author also examines the role of the professional unions of the intelligentsia in establishing business relations with the Soviet and Bolshevik Party authorities that occupied Ukraine at that time.
Results. Drawing on principally archival records and printed publications of that time the author identifies relevant to this day issues of the interrelations of the old intelligentsia and the Bolshevik regime in Ukraine, which did their best to earn the sympathy of the majority of the old intelligentsia, because this regime could not exist without the old intelligentsia. The Soviet authorities were able to upgrade the economy and create new culture only in cooperation with the old intelligentsia.
Novelty. Using the culturological methodology the author analyses the complicated processes of diversification of the views of the old intelligentsia in the course of unwanted establishment of business relations with the Soviet regime in Ukraine. The paper also describes the role of the professional unions of the intelligentsia in this process.
The practical significance. The results of this study can be used for further research of the issues mentioned above as well as in the process of studying other aspects of theory and history and of Ukrainian culture. They also can be used in the educational process while studying the courses of history of national culture.
A beginning and historical development of system of the required copy in Germany in the XV—XXI centuries
Authors: Bogdanov George
Published: April 2022

An article has іnterdisciplinary character and is at the interface of the document science, a history of the librarianship in Germany as well аs sectoral law written. The objects of study in the article are a hіstorical development of system of the obligatory copies in Germany from the age of modern history and legislation in the domain of addition of the obligatory copies of new published editions in the cource of last centuries. A serious consideration is to the struktur of distribution of the obligatory copies of publications as the whole as their certain types to the national, state and partly regional lіbraries paid. A insufficient elaborated legislation has as a consequence, the problems like a collecting of lіbraries with the Іnternet publicatіons or jurіdical aspects in the branch of carriage of the electronic publіcations are before now not fully investigated. An author describe generalized the ways for an addition of new electronic publications to the library and Web-Harvesting as a modern method for the arciving of the published works and their keeping as Іnternet forms. Moreover take place other topical problems in the brance of obligatory copies in Germany in the early 21st century, but they are today either up to now insufficiently investigated or aren't in general studed. Among their are the problem of copyright and your conform to the Internet publications and also a problem of competition. The quention arises: can the Internet publications as a source for the gratification of information needs with classical institutions like the libraries, archives or museums compete?
Development of Governance Indicators for Accessible and Inclusive Urban Developments (AIUDs)
Authors: AlKhamis Amal , Dweiri Fikri
Published: April 2022

This paper responds to the concern with the lack of public governance indicators for Accessible and Inclusive Urban Developments (AIUDs) despite agreements in the literature and in practice to develop field-specific governance indicators to resolve intricate problems. AIUD is known as a multi-disciplinary and multi-sectorial field requiring various sectors’ involvement. The resources needed to resolve this issue are scattered across diverse sectors. Furthermore, accessibility for and inclusion of disabled and elderly people is considered a global challenge. International organizations like the United Nations (UN), the Inclusion International (II) and the World Bank (WB) have addressed this concern. The UN prioritized this vital issue in its robust Sustainable Development Goals (SDGs) (2015-2030). AIUDs significantly impacted social inclusion, human welfare and economic development warrants developing governance indicators. This facilitates decision making, international performance comparisons, benchmarking, assessing governance quality and adopting corrective measures which improve the service delivery system. This study endeavours to develop a set of governance indicators for AIDUs in the UAE through a systematic literature review and the inputs gleaned from a group of experts by administering a questionnaire survey.
توظيف الوثيقة التاريخية في كتابات الشيخ سلطان بن محمد القاسمي(نماذج مختارة)
Authors: حياز خولة , شترة خير الدين
Published: April 2022

تهدف الدراسة إلى تناول إشكالية رئيسة تتمحور في أهمية الوثيقة في مؤلفات المؤرخ سلطان القاسمي لدورها البارز في أغلب مؤلفاته التاريخية، من خلال دراسة نماذج مختارة من مؤلفاته والتي اعتمد فيها على الوثيقة بصورة شبه كاملة، وذلك لمحاولة إيجاد إجابة عن التساؤلات الآتية: كيف وظّف المؤرخ سلطان القاسمي الوثيقة التاريخية في كتاباته؟ وهل طبق منهج النقد التاريخي على الوثائق التي استخدمها؟  وما الغاية التي سعى إلى تحقيقها من وراء استخدامه لها؟ وما أبرز الصعوبات التي واجهته؟ وللإجابة على هذه التساؤلات اعتمدت الدراسة على نماذج مختارة من مؤلفات المؤرخ سلطان القاسمي التاريخية، وفق منهج استدلالي يهدف إلى التعرف على جزئيات أبحاثه التاريخية، قصد تحديد العلاقات التي تربط بينها وبين مصادره الأرشيفية، وكذا مدى توافقها واتساقها مع الإطار العام لحركية المواضيع التاريخية التي درس وبحث فيها.
حالات الحكم بالإبعاد القضائي في التشريع الإماراتي "دراسة مقارنة"
Authors: الخيلي جمعة , العاني محمد , النوايسه عبدالإله
Published: April 2022

تبين لنا من دراسة موضوع حالات الإبعاد القضائي، بأنه موضوع يحظى بأهمية قانونية في مجال قانون العقوبات الاتحادي والتشريعات الجنائية الخاصة في دولة الإمارات العربية المتحدة، باعتباره جزاءً جنائياً قاسياً على الشخص الأجنبي الذي يدان بارتكاب جريمة معينة على أراضي دولة الإمارات التي يقيم فيها. وعليه فإن محل جزاء الإبعاد القضائي يكون الشخص الأجنبي الذي يرتكب إحدى الجرائم المنصوص عليها في كافة القوانين الجزائية الإماراتية. وأن القضاء الإماراتي هو الذي حدد ويقدر جسامة الخطورة الإجرامية التي يترتب عليها حكم تدبير الإبعاد.

وقد فرق المشرع الاتحادي بين نوعين من الإبعاد القضائي، وهما: الإبعاد القضائي الوجوبي، والإبعاد القضائي الجوازي. ففي الحالة الأولى حدد جملة من حالات الحكم بتدبير الإبعاد، وأوجب على المحكمة أن تأمر بإبعاد الأجنبي المحكوم عليه بعقوبة مقيدة للحرية في جميع الجنايات، ومنها الجنايات الواقعة على العرض والجرائم الماسة بأمن الدولة وجريمة الإضراب والجرائم الماسة بالعقائد والشعائر الدينية، هذا بالإضافة إلى بعض الحالات الأخرى الواردة في تشريعات جزائية خاصة نصت عليها قوانين عديدة، كقانون دخول وإقامة الأجانب وقانون مكافحة المواد المخدرة والمؤثرات العقلية وقانون جرائم مكافحة تمويل الإرهاب والاتجار بالبشر وقانون أحداث الجانحين والمشردين.
خصوصية الجرائم الماسّة بأمن الدولة (دراسة تحليلية للركنين المادي والمعنوي)
Authors: الوليد ساهر , نصار عدلي
Published: April 2022

خص المشرع العقابي الجرائم الواقعة على أمن الدولة بسياسة جنائية تختلف عن الجرائم الأخرى، ويأتي ذلك من منطلق خطورة هذه الجرائم وأهمية المصلحة التي يستهدف المشرع حمايتها؛ لذلك اعتمد المشرع على السياسة التحوطية، وقد ظهر ذلك بوضوح في بعض الجوانب المتعلقة بالركن المادي والركن المعنوي للجرائم الواقعة على أمن الدولة، وقد سلطت هذه الدراسة الضوء على مظاهر الخصوصية، ومن ذلك التوسع في تجريم مجرد التعريض للخطر، والتوسع في تجريم الشروع في التحريض، وتجريم ما هو أسبق من المحاولة الإجرامية من خلال تجريم الموقف النفسي المجرد المتمثل بالعزم لارتكاب جريمة الخيانة، وكذلك تجسدت هذه الخصوصية بالنص على فكرة الاشتراك في الجريمة بعد وقوعها بخصوص جريمة الخيانة، وعلى صعيد الخصوصية بشأن الركن المعنوي سلطت هذه الدراسة الضوء على الحالة التي تقوم فيها المسئولية رغم أن الجاني لم يتوقع النتيجة الإجرامية؛ إذ يسأل طالما أنه كان باستطاعته ومن واجبه أن يتوقعها وفقاً للمجرى العادي للأمور، وقد شغلت فكرة استطاعة التوقع حيزاً ليس بالقليل في نصوص الجرائم الواقعة على أمن الدولة، ونظراً لذلك عرضت هذه الدراسة لفكرة استطاعة التوقع وموقعها من الإثم الجنائي، وتطبيق هذه الفكرة والحيز الذي تشغله في نصوص الجرائم الواقعة على أمن الدولة في التشريع العقابي الفلسطيني.