bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of mycorrhizal fungi on the growth parameters of different cherry cultivars in the Kyustendil region
Authors:   Agricultural Academy, Institute of Agriculture, Kyustendil, 2500, Bulgaria, Petrova Vilina , Krumov Simeon ,   Agricultural Academy, Institute of Agriculture, Kyustendil, 2500, Bulgaria
Published: November 2023

The influence of arbuscular mycorrhizal fungi in the EC fertilizer Dynocarb MYC on the growth of 16 newly introduced cherry cultivars for the Kyustendil region - Primulat, Early Lorry, Sweet Lorry, Lorry Bloom, Big Lorry, Giant Red, Firm Red, Giorgia, Folfer, Early Star, Simcoe, Canada Giant, Skeena, Katalin, Sweetheart, Ferrovia, Bigarreau Burlat and Van was monitored. It was established that applying Dynocarb MYC positively affected the growth properties of the trees in all investigated cultivars. Regarding trunk diameter (cm²), differences compared to controls were positively demonstrated in Skeena, Firm Red, Early Star, Giant Red and Lorry Bloom. Растениевъдни науки, 2023, 60(5) Bulgarian Journal of Crop Science, 2023, 60(5) https://doi.org/10.61308/NYAB1154 77 For the other cultivars, the differences were insignificant, but the tendency was positive. The trees of the treated variants were proven to be higher in the cultivars Early Lorry, Firm Red, Early Star, Sweetheart, Ferrovia, Skeena, Katalin, Lorry Bloom, Bigarreau Burlat, and Van. In the treated cultivars, a greater average length of annual shoots was found in the cultivars Early Lorry, Firm Red, Early Star, Sweetheart, Ferrovia, Skeena, Katalin, Lorry Bloom, Bigarreau Burlat and Van.
Influence of drought on the heading in Bulgarian triticale cultivars
Authors:   Agricultural Academy, Dobrudzha Agricultural Institute – General Toshevo, 9521, General Toshevo, Bulgaria, Stoyanov Hristo
Published: November 2023

In order to study how the heading changes in exposure under the influence of natural drought processes and whether such a change affects crop productivity, 17 cultivars of winter hexaploid triticale were studied during 7 contrast growing periods. The results show that the latest heading is observed in the 2016/2017 growing period, and the earliest in the 2015/2016. During the period with the most pronounced soil and atmospheric drought - 2019/2020, the heading was earlier than the other periods. There is a tendency for the varieties AD-7291 and Vihren the heading to be earlier than the others, regardless of the environmental conditions. A tendency to later heading than the other cultivars is observed in Respect. On the other hand, early-heading cultivars have a positive effect on productivity, especially in periods of severe drought. Despite the differences observed in the heading period under the influence of drought, productivity of the cultivar Bumerang remains high. This shows that the cultivar has a high tolerance to soil drought, which makes it extremely suitable for growing in various soil and climatic conditions of Bulgaria.
ChatGPT: Unlocking the future of NLP in finance
Authors: Zaremba Adam , Demir Ender
Published: November 2023

This paper reviews the current state of ChatGPT technology in finance and its potential to improve existing NLP-based financial applications. We discuss the ethical and regulatory considerations, as well as potential future research directions in the field. The literature suggests that ChatGPT has the potential to improve NLP-based financial applications, but also raises ethical and regulatory concerns that need to be addressed. The paper highlights the need for research in robustness, interpretability, and ethical considerations to ensure responsible use of ChatGPT technology in finance.
ANALISIS PUISI ANAK " SANG SURYA " KARYA LIA MAYLANI HENDRIYANTI DENGAN PENDEKATAN STRUKTURAL
Authors: Assya'bani Ridhatullah , Naziah Bahjatun
Published: November 2023

Puisi merupakan ungkapan perasaan penyair yang dirangkai dengan bahasa yang indah dan mengandung makna yang dalam. Oleh karena itu, untuk memahami makna dari sebuah puisi, diperlukan analisis yang lebih mendalam. Penelitian ini bertujuan untuk menganalisis puisi berjudul Sang Surya karya Lia Maylini Hendriyanti menggunakan pendekatan struktural. Metode yang digunakan dalam penelitian ini adalah metode kualitatif yang berfokus pada analisis isi puisi berdasarkan unsur fisik dan unsur batin puisi. Unsur fisik puisi yang akan dianalisis meliputi diksi, rima, tipografi, pengimajian, kata konkret, dan gaya bahasa. Sedangkan unsur batin puisi yang akan dianalisis meliputi tema, nada, rasa, dan amanat. Pada penelitian ini sumber data yang digunakan sebagai objek analisis
LEARNING DIFFICULTIES OF CHILDREN WITH SPECIAL NEEDS SLOW LENEAR IN MATHEMATICS LEARNING AT SDN BANUA ANYAR 4 BANJARMASIN
Authors: Hirawatillah Hijrah , Abdul Aziz Abdul Rashid , Kamal Ahlal
Published: November 2023

This study examines the learning difficulties of children with special needs slow lenear in mathematics learning at SDN Banua Anyar 4 Banjarmasin. Departing from the assumption that learning mathematics is very difficult and boring, coupled with the problems that exist in children, namely slow learning and receiving information (slow lenear), it is necessary to study this problem. This research is a field research using qualitative methods with observation, documentation and interview techniques. From this study provides information that the difficulty that often occurs in slow lenear children is difficulty in understanding symbols, distinguishing between letters and numbers, and upper and lower case letters. In addition to the difficulties experienced by students, accompanying teachers also experience several obstacles such as not having media when accompanying students slow lenear learning and lack of accompanying teachers so that they are tired when accompanying students while studying.
CHARACTERISTICS OF ORIENTALISM STUDIES AND IMPLICATIONS FOR THE ISLAMIC WORLD
Authors: Sapariah Jamiatun , Rezky Laily , Ajmi Syauhan , Abdul Aziz Abdul Rashid
Published: November 2023

This study aims to analyze the study of orientalism through a qualitative approach to literature study, which will be observed based on several indicators, namely in terms of understanding, characteristics, and implications for the Islamic world. Initially, Orientalism was understood as an understanding carried out by Westerners to explore the East, both in terms  of religion and civilization. The study of Orientalism has a strong relationship with Western colonialism in the Eastern world, colonialism, imperialism, missionarism and Christianization movements. In its development, orientalism gave another color through the emergence of controversial things circulating about Islam such as damaging  the real image of Islam, opportunities to enrich Islamic studies and introduce the original face of Islam rahmatan lilalamin, joy for the western world that began to recognize Islamic civilization, its contribution in the field of translation as well as Eastern scholarship, and encouragement in efforts to achieve peace. With this study we can also understand not always negative orientalists, but there are also those who purely as academics make themselves objective researchers.  So that thefaith of Muslims in orientalism should not be shown through emotions, and diversity of judgments of  Islam also exists. However, there is nothing wrong with staying vigilant  and caring  for aqidah by increasing faith in Allah SWT  and making this motivation through the need for intention and deepening shahih  knowledge, especially in the current era
A Comparative Study on Social Policies for Disabled Labor Force between Indonesia and Australia
Authors: Varianto Zicko
Published: November 2023

Disabled labor force have the same rights and potential to contribute to economic activities regardless of their limitation and incapability. This paper is comparing the social security of disabled labor force between Indonesia and Australia. Indonesia is still a developing country with an archipelago form while Australia is one massive area with vast array of ecosystem. Both countries have strong diversity with many races live together. While in some aspects both of the countries might have some similarities, but as for welfare states, both are very different. This research involved eight disabled people in Jakarta. This research looks at whether the social class of disabled people also affecting their capabilities and social capital, thus also affecting their chances to enter the labour market. The findings show that digital economy duplicates the effect on social class, where it does not accessible for all social class of the disabled people and create a more significant gap between classes.
Social Protection for Indonesian Domestic Workers in Taiwan
Authors: Reza Yusup Muhammad
Published: November 2023

When working overseas, domestic workers are susceptible to a variety of risks that can compromise their level of living. These risks encompass a variety of types, including health and work accidents. Social protection is a form of action or policy that is present to counteract this. Nonetheless, the activities of domestic workers who work abroad cause the social protection that is applied to them is not only from one side, namely the country of origin or the country of destination,  but also  both. The purpose  of this paper  is to examine  various types of  social protection for Indonesian domestic workers in Taiwan. This paper analyzes the experiences and knowledge of five informants who have or are now employed as domestic workers in Taiwan by interviewing them about their access to or utilization of the various social protection programs available to them. The discussion of their experiences is separated into two types of social protection: formal, provided by the governments of Indonesia as well as the government of Taiwan, and informal. The findings of this paper indicate that, on the one hand, the informants do not share the same awareness of the existence of social protection provided by the Indonesian government and, on the other hand, they are aware of and have utilized the health insurance provided by the Taiwanese government, although they do not share the same understanding of other insurances, such as the work accident insurance provided under the employment contract. Moreover, donations and training provided by non-government agencies are identifiable informal social protection in this study. This paper also argues that the awareness of Indonesian domestic workers about the importance of social protection can be improved by providing socialization regarding awareness of their future potential risks.
Effectiveness of Cell Management Education for Patients with Diabetes Mellitus: A Systematic Review
Authors: Arian Febrila Dewanti Neni , Susanti Indah , Fikar Lanjari Zul , Feibirini Fitri
Published: November 2023

Background: Diabetes mellitus is a chronic disease that ranks as the fourth leading cause of death in developing countries. The main pillars in the management of type 2 Diabetes Melitus (T2DM) are education, nutritional therapy, physical training, and pharmacological interventions. The provision of education that has had a positive impact on DM patients is the Diabetes Self-Management Education (DSME). Method: The purpose of this study was to evaluate the effectiveness of the application and web-based Diabetes Self-Management Education (DSME) method in patients with type 2 DM. This study used a systematic literature review design. Articles were collected through PubMed and Google Scholar databases using the keywords DSME Web Application, DSME Smartphone. The criteria for articles used were those published from 2014-2020. Results: the literature review show that the application-based DSME method is more effective in improving self-management of type 2 DM sufferers. Search for articles related to 9 sources that fall within the criteria. Conclusion: is that the application-based DSME method is more effective because it does not require a lot of money and a long time compared to doing direct control to health facilities, the application can also always be accessed whenever we want so that it can help improve self-management in people with Diabetes Mellitus
Chest Physiotherapy to Manage Respiratory Rate In Patients with Bronchopneumonia: A Literature Review
Authors: Bisma Yudha Magenda , Wardoyo Eko
Published: November 2023

Purpose: Knowing the application of chest physiotherapy techniques can manage respiratory rates in children with bronchopneumonia. Methods: This review uses the literature review method. Searches were conducted in PubMed, Garuda, and Google Scholar. The search strategy used keywords with "bronchopneumonia", "chest", "physiotherapy", "respiratory rate". Findings: There were eight articles reviewed in this literature review. Seven articles discussed the application of chest physiotherapy and one article discussed the combination of nebulization therapy and chest physiotherapy in bronchopneumonia or pneumonia patients in children. The overall results of this review show that the application of chest physiotherapy in airway clearance problems in children with bronchopneumonia or pneumonia is effective in removing sputum, diluting sputum, and stabilizing hemodynamic status.  Conclusions: The application of chest physiotherapy in children with bronchopneumonia or pneumonia has been shown to stabilize hemodynamic status such as pulse frequency, respiratory rate frequency, oxygen saturation within normal limits, and can remove secretions, sputum, and reduce cough frequency.
The Correlation between Motivation and Anesthetists’ Working Performance in Banyumas Regency
Authors: Achmad Fadilah Rizal , Sukmaningtyas Wilis , Burhan Asmat
Published: November 2023

Background: The performance of health workers is a very crucial issue to be studied in order to maintain and improve health services. The impact that occurs if the performance of health workers in the hospital is not good can cause patients and families to feel dissatisfied, patients and families will not use health services again. One of the factors that affect performance is motivation. Objective: Knowing the relationship between motivation and the performance of anesthesiologists in the Banyumas Regency area. Research: The research method is correlation analytics research with a cross sectional approach. The sampling technique used total sampling, a total of thirty-nine respondents. Data collection using work motivation and performance questionnaires. Bivariate analysis using spearman-rank. Results: The results of the study obtained a percentage of 39 respondents of anesthesiologists in the Banyumas Regency area with sufficient motivation as many as 28 respondents (71.79%) and respondents who had sufficient performance as many as 31 respondents (79.98%). The results of spearman-rank analysis showed a significant relationship, work motivation with the performance of anesthesiologists with a correlation value of 0.733 and a 2-tailed sig of 0.000.  Conclusion: Advice for the anesthesiologist profession who is especially incorporated in the organization at the DPC IPAI Banyumas Branch Secretariat which researchers recommend is expected to improve the quality and quantity of health services to patients and families, namely by carrying out predetermined procedures and friendly, so that patients and families feel comfortable and served with satisfaction for the services provided.
An overview of patient knowledge of anesthesia procedures through informed consent in the Jatiwinangun Purwokerto Surgical Specialty Hospital's central surgical installation
Authors: Hari Perkasa Tubagus , Nova Handayani Rahmaya , Burhan Asmat
Published: November 2023

Background: The submission of informed consent aims to obtain evidence of consent that can document legal and ethical liability. Anesthesia procedures include pre-anesthesia, intra-anesthesia and post-anesthesia. Pre-anesthesia is a pre-anesthesia and sedation assessment, informed consent for anesthesia and sedation, giving premedication drugs if necessary, and instructing fasting before surgery. Purpose: This study was to determine the level of patient knowledge about anesthesia procedures through informed consent at the Central Surgical Installation of Jatiwinangun Purwokerto Special Surgical Hospital. Methods: This study used a quantitative descriptive design with a cross sectional approach. The sampling technique used consecutive sampling of 108 respondents. The measuring instrument used was a questionnaire sheet. Analysis test using univariate test. Results: The analysis showed that the most dominant age of respondents was in the range of 36-45 years (23.4%), with the last education having a high school background (35%) and male (59.3%). Conclusion: An overview of the patient's knowledge level about anesthesia procedures through informed consent in the central surgical installation of Jatiwinangun Purwokerto Special Surgical Hospital, the majority have a sufficient level of knowledge.
The Relationship between Hypertension and Anxiety Level in the Elderly in Mandungan Srimatani Sub-district Piyungan Bantul Regency Yogyakarta
Authors: Isnaeni Yeni , Nur Adkhana Sari Dian , Nur Hartiningsih Sri
Published: November 2023

ABSTRACT

 

Background: Hypertension is still a problem for the elderly, the changes experienced by the elderly will experience a lot of decline, both physically, mentally, and socially. As an age that shows the aging process, this condition makes high blood pressure a health problem for the elderly. A person is said to have hypertension and has a systolic and diastolic blood pressure of 140/90 mmHg. Hypertension is often found in the elderly, the physical limitations experienced by the elderly will experience anxiety because the various diseases they suffer do not go away and even get worse in the end they experience psychological disorders, namely anxiety, which is marked by deep and ongoing fears and worries.

Objective: To determine the relationship between hypertension and anxiety levels in the elderly in Mandungan Srimartani Hamlet, Piyungan District, Bantul Regency, Yogyakarta.

Methods: This research is non-experimental with a correlation study using a cross sectional approach, and the sample size is 39 respondents aged 60-80 years.

Results: The data that has been analyzed using the Kendall-Tau test has a correlation coefficient value of 0.483** and a significant value of 0.001 < 0.005.

Conclusion: There is a relationship between hypertension and anxiety levels in Mandungan Srimartani Hamlet, Piyungan District, Bantul Regency, Yogyakarta.

 

 

 

Keywords: Hypertension, Anxiety Level, Elderly
Med handicap i vuggestuen
Authors: Bendix-Olsen Kurt
Published: November 2023

Artiklen udforsker ressourcebørnehuses inklusionsarrangementer med henblik på at undersøge, hvordan vuggestuebørn med handicap har mulighed for at tage del i hverdagen. Gennem en indkredsning af de professionelles bestræbelser på inklusion fremanalyserer artiklen tre gensidigt kontrasterende pædagogiske inklusionsarrangementer: et kapaci- tetsfokuseret arrangement, et rummende omsorgsarrangement og et repertoireskabende arrangement. De to førstnævnte arrangementer peger på, at inklusion af børn med handicap ofte organiseres ud fra binære forståelser af børns behov som enten almene eller særlige. I et arrangement, der er kapacitetsfokuseret lægger de professionelle vægt på planmæssig udvikling af det ‘funktionsnedsatte’ barns potentielle kropsfunktioner, og de arbejder med (re)habilitering med henblik på at styrke barnets alderssvarende udvikling og fremadrettet at sikre dets kapaciteter. I et rummende omsorgsarrangement er de professionelles handlinger rettet mod at drage omsorg for såvel det særlige som for det almene. Det er et omsorgsarrangement, hvor ‘børn med særlige behov’ rummes “i egen ret” i en hverdag, der primært er tilrettelagt efter den almene børnegruppes behov. I et repertoireskabende arrangement overskrides den binære opdeling mellem det almene og det særlige, idet den hverdagslige udvikling af praksis har afsæt i børnenes igangværende engagementer, og de professionelles målsætninger bidrager til at udvide børnefællesskabernes fælles deltagelsesrepertoire. De professionelles inklusionsbestræbelser kan i et repertoireskabende arrangement karakteriseres som pædagogisk afsøgende og eksperimenterende med øje for børnefællesskabernes mulighedshorisonter.
Kurdové a druhá světová válka: Několik úvah z pohledu sociálních dějin
Authors:   University of Neuchâtel, History Department, Espace Tilo-Frey 1, 2000 Neuchâtel, Switzerland, Tejel Jordi
Published: November 2023

Vědci obecně tvrdí, že během druhé světové války byl Blízký východ, a zejména kurdské oblasti, okrajovou oblastí jinak globální války. Ačkoli je to do značné míry pravda, zdá se, že je nutné do této analýzy vnést některé nuance. Pohled z pohraničí v kombinaci se sociálně-historickým přístupem k tomu, jak byla válka každodenně prožívána za frontovou linií, ukazuje, že vojenské napětí, rozsáhlé pašování zbraní, inflace, nedostatek potravin a ekonomická migrace byly v kurdském pohraničí v letech 1941-1945 běžnými rysy. Kromě toho nám pohled na neradostné události může pomoci lépe pochopit kontext, v němž se kurdské nacionalistické hnutí během války a v bezprostředně poválečných letech rozvíjelo.
Design Objectives for Evolvable Knowledge Graphs
Authors: Teern Anna , Kelanti Markus , Päivärinta Tero , Karaila Mika
Published: November 2023

Knowledge graphs (KGs) structure knowledge to enable the development of intelligent systems across several application domains. In industrial maintenance, comprehensive knowledge of the factory, machinery, and components is indispensable. This study defines the objectives for evolvable KGs, building upon our prior research, where we initially identified the problem in industrial maintenance. Our contributions include two main aspects: firstly, the categorization of learning within the KG construction process and the identification of design objectives for the KG process focusing on supporting industrial maintenance. The categorization highlights the specific requirements for KG design, emphasizing the importance of planning for maintenance and reuse.
An Actor-Oriented and Architecture-Driven Approach for Spatially Explicit Agent-Based Modeling
Authors:   Department of Computer Engineering, Fotso Victor University Institute of Technology, P.O. box 134, Bandjoun, Cameroon, Fotsing Eric , Kakeu Severin Vianey Tuekam ,   Department of Mathematics and Computer Science, URIFIA Laboratory, University of Dschang, P.O. box 67, Dschang, Cameroon, Kameni Eric Desire ,   Department of Computer and Educational Technology, Laboratory of Computer Science and Educational Technologies (LITE), Higher Teacher Training College, University of Yaoundé I, P.O. box 47, Yaoundé, Cameroon, Nkenlifack Marcellin Julius Antonio ,   Department of Computer Engineering, Fotso Victor University Institute of Technology, P.O. box 134, Bandjoun, Cameroon,   Department of Mathematics and Computer Science, URIFIA Laboratory, University of Dschang, P.O. box 67, Dschang, Cameroon
Published: November 2023

Nowadays, there is an increasing need to rapidly build more realistic models to solve environmental problems in an interdisciplinary context. In particular, agent-based and spatial modeling have proven to be useful for understanding land use and land cover change processes. Both approaches include simulation platforms often used in several research domains to develop models explaining and analyzing complex phenomena. Domain experts generally use an ad hoc approach for model development, which relies on a code-and-fix life cycle, going from a prototype model through progressive refinement. This adaptive approach does not capture systematically actors’ knowledge and their interactions with the environment. The development and maintenance of resulting models become cumbersome and time-consuming. In this article, we propose an actor and architecture-driven approach that relies on relevant existing methods and satisfies the needs of spatially explicit agent-based modeling and implementation. We have designed an Agent Global Experiment framework incorporating a meta-model built from actor, agent architecture, and spatial concepts to produce an initial model from specifications provided by domain experts and system analysts. An engine is built as a tool to support model transformation. Domain knowledge including spatial specifications is summarized in a class diagram which is later transformed into the agent-based model. Finally, the XML file representing the model produced is used as input in the transformation process leading to code. This approach is illustrated on a hunting and population dynamic model to generate a running code for GAMA, an agent-based and spatially explicit simulation platform.
Rural settlement network of Tarsky district (uyezd) at the end of the XIX – first third of the XX centuries: patterns and features of transformation
Authors: Tatarnikova Anna Ivanovna , Saifulina Nadezhda Alekseevna
Published: November 2023

The paper characterizes the development of rural settlements on the territory of the Tarsky district, the planned settlement of the urban spaces of which under the control of the government began in the mid-1890s and continued for several decades. The subject of the study is the network of rural settlements of the Tarsky district, the object is the key indicators of the state of the network: the number of settlements, their typology and size by the number of yards and the number of inhabitants. The development of the settlement network can be traced in historical dynamics, according to several time slices (for 1893, 1903, 1912 and 1926), the choice of which is due to the peculiarities of the source base of the study. The novelty of the presented work consists in a comparative analysis of the indicators of the development of Tar villages in the late Imperial and early Soviet periods, determining the scale of the settlement network, identifying patterns and specifics of its functioning and transformation. Conclusions are drawn about the increase in the number of settlements in the district in the period from 1893 to 1926 by more than four times (from 447 to 1946 villages), changes in the typical structure of the network: the predominant in the late 1890s resettlement settlements and villages in the 1900s were replaced by farms that in the mid-1930s began to forcibly settle in large collective farms (collective farms). There has been a reduction in the number of households and the population of settlements.
Comparative Interactome Analysis of α-arrestin Families in Human and Drosophila
Authors: Lee Kyung-Tae , Pranoto Inez K.A. , Kim Soon-Young , Choi Hee-Joo , To Ngoc Bao , Chae Hansong , Lee Jeong-Yeon , Kim Jung-Eun , Kwon Young V. , Nam Jin-Wu
Published: November 2023

The α-arrestins form a large family of evolutionally conserved modulators that control diverse signaling pathways, including both G-protein-coupled receptor- (GPCR-) mediated and non-GPCR mediated pathways, across eukaryotes. However, unlike β-arrestins, only a few α-arrestin targets and functions have been characterized. Here, using affinity purification and mass spectrometry, we constructed interactomes for six human and twelve
Drosophila
α- arrestins. The resulting high-confidence interactomes comprised 307 and 467 prey proteins in human and
Drosophila
, respectively. A comparative analysis of these interactomes predicted not only conserved binding partners, such as motor proteins, proteases, ubiquitin ligases, RNA splicing factors, and GTPase-activating proteins, but also those specific to mammals, such as histone modifiers and the subunits of V-type ATPase. Given the manifestation of the interaction between the human α-arrestin, TXNIP, and the histone-modifying enzymes, including HDAC2, we undertook a global analysis of transcription signals and chromatin structures that were affected by TXNIP knockdown. We found that TXNIP activated targets by blocking HDAC2 recruitment to targets, a result that was validated by chromatin immunoprecipitation assays. Additionally, the interactome for an uncharacterized human α-arrestin ARRDC5 uncovered multiple components in the V-type ATPase, which plays a key role in bone resorption by osteoclasts. Our study presents conserved and species-specific protein-protein interaction maps for α-arrestins, which provide a valuable resource for interrogating their cellular functions for both basic and clinical research.
Foveated metamers of the early visual system
Authors: Broderick William F. , Rufo Gizem , Winawer Jonathan , Simoncelli Eero P.
Published: November 2023

Human ability to discriminate and identify visual attributes varies across the visual field, and is generally worse in the periphery than in the fovea. This decline in performance is revealed in many kinds of tasks, from detection to recognition. A parsimonious hypothesis is that the representation of any visual feature is blurred (spatially averaged) by an amount that differs for each feature, but that in all cases increases with eccentricity. Here, we examine models for two such features: local luminance and spectral energy. Each model averages the corresponding feature in pooling windows whose diameters scale linearly with eccentricity. We performed psychophysical experiments with synthetic stimuli to determine the window scaling for which human and model discrimination abilities match, called the critical scaling. We used much larger stimuli than those of previous studies, subtending 53.6 by 42.2 degrees of visual angle. We found the critical scaling for the luminance model was approximately one-fourth that of the energy model, and consistent with earlier studies, that a smaller critical scaling value was required when discriminating a synthesized image from a natural image than when discriminating two synthesized images. We offer a coherent explanation for these results in terms of alignments and misalignments of the models with human perceptual representations.
Characterization of the cellular components of mouse collecting lymphatic vessels reveals that lymphatic muscle cells are the innate pacemaker cells regulating lymphatic contractions
Authors: Zawieja SD , Pea GA , Broyhill SE , Patro A , Bromert KH , Norton CE , Kim HJ , Sivasankaran SK , Li M , Castorena-Gonzalez JA , Drumm BT , Davis MJ
Published: November 2023

Collecting lymphatic vessels (cLVs) exhibit spontaneous contractions with a pressure-dependent frequency, but the identity of the lymphatic pacemaker cell is still debated. By analogy to pacemakers in the GI and lower urinary tracts, proposed cLV pacemaker cells include interstitial cells of Cajal like cells (ICLC) or the lymphatic muscle (LMCs) cells themselves. Here we combined immunofluorescence and scRNAseq analyses with electrophysiological methods to examine the cellular constituents of the mouse cLV wall and assess whether any cell type exhibited morphological and functional processes characteristic of pacemaker cells: a continuous if not contiguous network integrated into the electrical syncytium; spontaneous Ca
2+
transients; and depolarization-induced propagated contractions. We employed inducible Cre (iCre) mouse models routinely used to target these specific cell populations including: c-kitCreER

T2

to target ICLC;

PdgfrβCreER
T2

to target pericyte-like cells;

PdgfrαCreER
TM

to target CD34
+
adventitial cells and ICLC; and

Myh11CreER
T2

to target LMCs directly. These specific inducible Cre lines were crossed to the fluorescent reporter ROSA26mT/mG, the genetically encoded Ca
2+
sensor GCaMP6f, and the light-activated cation channel rhodopsin2 (ChR2). c-KitCreER

T2

labeled both a sparse population of LECs and round adventitial cells that responded to the mast cell activator compound 48-80.

PdgfrβCreER
T2

drove recombination in both adventitial cells and LMCs, limiting its power to discriminate a pericyte-specific population.

PdgfrαCreER
TM

labeled a large population of interconnected, oak leaf-shaped cells primarily along the adventitial surface of the vessel. Of these cells, only LMCs consistently, but heterogeneously, displayed spontaneous Ca
2+
events during the diastolic period of the contraction cycle, and whose frequency was modulated in a pressure-dependent manner. Optogenetic depolarization through the expression of ChR2 under control of

Myh11CreER
T2

, but not

PdgfrαCreER
TM

or c-KitCreER

T2

, resulted in propagated contractions upon photo-stimulation. Membrane potential recordings in LMCs demonstrated that the rate of diastolic depolarization significantly correlated with contraction frequency. These findings support the conclusion that LMCs, or a subset of LMCs, are responsible for mouse cLV pacemaking.
EQUIVALENT EXCITABILITY THROUGH DIFFERENT SODIUM CHANNELS AND IMPLICATIONS FOR THE ANALGESIC EFFICACY OF SELECTIVE DRUGS
Authors: Xie Yu-Feng , Yang Jane , Ratté Stéphanie , Prescott Steven A.
Published: November 2023

Nociceptive sensory neurons convey pain signals to the CNS using action potentials. Loss-of-function mutations in the voltage-gated sodium channel Na V 1.7 cause insensitivity to pain (presumably by reducing nociceptor excitability) but efforts to treat pain by inhibiting Na V 1.7 pharmacologically have largely failed. This may reflect the variable contribution of Na V 1.7 to nociceptor excitability. Contrary to claims that Na V 1.7 is necessary for nociceptors to initiate action potentials, we show that nociceptors can achieve equivalent excitability using different combinations of Na V 1.3, Na V 1.7, and Na V 1.8. Selectively blocking one of those Na V subtypes reduces nociceptor excitability only if the other two subtypes are weakly expressed. For example, excitability relies on Na V 1.8 in acutely dissociated nociceptors but responsibility shifts to Na V 1.7 and Na V 1.3 by the fourth day in culture. A similar shift in Na V dependence occurs in vivo after inflammation, impacting ability of the Na V 1.7-selective inhibitor PF-05089771 to reduce pain in behavioral tests. Flexible use of different Na V subtypes – an example of degeneracy – compromises the reliable modulation of nociceptor excitability by subtype-selective inhibitors. Identifying the dominant Na V subtype to predict drug efficacy is not trivial. Degeneracy at the cellular level must be considered when choosing drug targets at the molecular level.Nociceptors can achieve equivalent excitability using different sodium channel subtypes. The analgesic efficacy of subtype-selective drugs hinges on which subtype controls excitability. This contingency likely contributes to poor clinical outcomes.
β-catenin inhibition disrupts the homeostasis of osteogenic/adipogenic differentiation leading to the development of glucocorticoid-induced osteonecrosis of femoral head
Authors: Xia Chenjie , Xu Huihui , Fang Liang , Chen Jiali , Yuan Wenhua , Fu Danqing , Wang Xucheng , He Bangjian , Xiao Luwei , Wu Chengliang , Tong Peijian , Chen Di , Wang Pinger , Jin Hongting
Published: November 2023

Glucocorticoid-induced osteonecrosis of the femoral head (GONFH) is a common refractory joint disease characterized by bone damage and the collapse of femoral head structure. However, the exact pathological mechanisms of GONFH remain unknown. Here, we observed abnormal osteogenesis and adipogenesis associated with decreased β-catenin in the necrotic femoral head of GONFH patients. In vivo and in vitro studies further revealed that glucocorticoid exposure disrupted osteogenic/adipogenic differentiation bone marrow stromal cells (BMSCs) by inhibiting β-catenin signaling in glucocorticoid-induced GONFH rats. Col2
+
lineage largely contributes to BMSCs, and was found an osteogenic commitment in the femoral head through 9 months of lineage trace. Specific deletion of
β-catenin
in Col2
+
cells shifted their commitment from osteoblasts to adipocytes, leading to a full spectrum of disease phenotype of GONFH in adult mice. Overall, we uncover that β-catenin inhibition disrupting the homeostasis of osteogenic/adipogenic differentiation contribute to the development of GONFH, and identify an ideal genetic modified mouse model of GONFH.
A benzochalcone derivative synchronously induces apoptosis and ferroptosis in pancreatic cancer cells
Authors: Guan Xiaoqing , Zhao Bing , Guan Xiaodan , Dong Jinyun , Ying Jieer
Published: November 2023

Background

Pancreatic cancer is a highly aggressive and lethal disease with limited treatment options. In this study, we investigated the potential therapeutic effects of compound KL-6 on pancreatic cancer cells.

Methods

The study involved assessing the inhibitory effects of KL-6 on cell proliferation, clonogenic potential, cell cycle progression, apoptosis, migration, and invasion. Additionally, we examined the action mechanism of KL-6 by RNA-seq and bioinformatic analysis and validated by qRT-PCR and western blot in pancreatic cancer cells.

Results

Our results demonstrated that KL-6 effectively inhibited the growth of pancreatic cancer cells in a dose-dependent manner. It induced G2/M phase cell cycle arrest and apoptosis, disrupting the cell cycle progression and promoting cell death. KL-6 also exhibited inhibitory effects on cell migration and invasion, suggesting its potential to suppress the metastatic properties of pancreatic cancer cells. Furthermore, KL-6 modulated the expression of genes involved in various cancer-related pathways including apoptosis and ferroptosis.

Conclusion

These findings collectively support the potential of KL-6 as a promising therapeutic option for pancreatic cancer treatment. Further research is needed to fully understand the underlying mechanisms and evaluate the clinical efficacy of KL-6 in pancreatic cancer patients.
Factors affecting the start-up environment to start-up intention of students in the university of economy in the Mekong Delta, Vietnam
Authors: Tri Nguyen Giac
Published: November 2023

This study aims to evaluate the factors affecting the start-up environment to the entrepreneurial intention of students majoring in economics at universities in the Mekong Delta. Research data is collected from 500 final year students, majoring in economics of 10 universities in the Mekong Delta with a high percentage of students starting a business after graduation. The study was carried out through two phases: qualitative research and quantitative research. Besides, the data analysis method was selected (1) to assess the reliability of the Cronbach's Alpha scale; (2) exploratory factor analysis (EFA); (3) Pearson correlation coefficient test to measure the relationship between variables; (4) linear regression analysis. The research results show, environmental factors including perceived barriers in the start-up environment, environment to encourage entrepreneurship at university and social perception of business owners have an influence on the intention to start a business. students' careers.
Training Need Assessment of Rythu Bharosa Kendra (RBK) Staff of SPSR Nellore District of Andhra Pradesh, India
Authors: Babu S. Lokesh , Reddy K. Kiran Kumar , Obaiah M. C. , Jyothi G. Lalitha Siva , Rao B. Mukunda
Published: November 2023

The present study was conducted during the year 2022-23 by following Ex-Post-Facto research design with objective of studying the Training Need Assessment of Rythu Bharosa Kendra (RBK) Staff of SPSR Nellore District of Andhra Pradesh, India. A total of 120 RBK staff of SPSR Nellore district from 08 agriculture divisions were interviewed with help of prestructured interview schedule. The findings of the current study indicate that concerning Crop Production, subjects such as Integrated Farming Systems, Cropping Systems, and the management of Micro-Nutrient Deficiencies have emerged as particularly crucial areas that require focused training for the RBK staff in the sampled region. Regarding the aspects of Crop Protection, the RBK staff highlighted a need for training in Integrated Pest Management, Integrated Disease Management, and the implementation of Biocontrol Methods. In the domain of Horticulture, the RBK staff expressed a need for training in various areas, including the Package of Practices for Plantation Crops, the techniques of Nursery Establishment and Management, as well as the processes of Grading and Quality Assessment. Regarding the management of dairy operations, the training priorities for RBK staff are centered around Milking Management and Housing Management, which have been identified as particularly important areas. Concerning the challenges encountered by RBK staff, the most significant constraint identified is the insufficiency of equipment, infrastructure, and essential resources. This is followed by the difficulty of effectively managing multiple schemes simultaneously and coping with a heavy workload, along with a high frequency of monthly meetings.
Small-Scale Chicken Farmers’ Use of Social Media to Access Market Information in Arusha City, Tanzania
Authors: Almasi Juma , Mwaseba Dismas L. , Athman Ahmad K. , Shausi Gosbert L.
Published: November 2023

The aim of this study was to examine the small-scale chicken farmer’s use of social media platforms to access market information in Arusha city, Tanzania. Data were collected between June and August 2022 from 260 small-scale chicken farmers (SSCFs). Among these, 130 were Kuku Uchumi and 130 were non-Kuku Uchumi beneficiaries selected using stratified and simple random technique. Both quantitative and qualitative data were collected using questionnaire and key informant interview guide, respectively. Descriptive statistics, chi-square test, and binary logistic regression model were used to analyse quantitative data. On the other hand, qualitative data were transcribed from audio and translated from Kiswahili to English, and extracts were developed. The study found that chicken price, egg tray price, the number of chicken, and egg trays needed in the market and chicken market status were the main chicken market information accessed by SSCFs through social media. WhatsApp was reported as the primary social media used by SSCFs to access market information. The findings also, indicate statistically significant differences between Kuku Uchumi and non-Kuku Uchumi beneficiaries in using social media to access market information. The study concludes that using social media to access market information assists SSCFs in finding markets for their chicken and eggs, and recommends to other SSCFs to use social media. Furthermore, Kuku Uchumi's modes of training and mobilization may be advocated by extension agents in other areas
Post Harvest Handling of Fruit Crops
Authors: Jain Shubham , Saxena Saransh , Minz Varsha , Behera Swosti Debapriya , Harini Korani , Shivani  , Mishra Satyam , Nidhi Nivedita
Published: November 2023

Fruits are classified as perishable agricultural commodities. When fruits are harvested prematurely or when they are overripe, their storage life is shortened and their quality deteriorates. Therefore, it is important to harvest fruits at the appropriate stage of maturity in order to ensure good quality and better storage. Nevertheless, the inadequate implementation of proper handling techniques for agricultural produce has led to a significant occurrence of post-harvest losses, resulting in the wastage of valuable resources such as time and financial investments. The lack of appropriate handling procedures and chemical treatment methods are leading to significant losses in commodities. Therefore, it can be deduced that producers are currently experiencing significant economic detriment as a result of inadequate handling techniques, insufficient understanding of the underlying factors contributing to postharvest loss, and a dearth of effective preservation methodologies. However, the mitigation of loss can be achieved through the implementation of appropriate management and handling procedures. This review focuses on various aspects of post-harvest handling methods for preservation of fruits for longer time for processing and value addition.
Seaweed Extract's Effect on Carrot (Daucus carota. L) Growth. Super Kuroda
Authors: Kavya Vendra Sai , Parameswari Y. S. , Reddy M. Venkateswara , Kumari B. Anila
Published: November 2023

A field experiment was conducted during rabi 2022 on carrot variety ‘Super kuroda’ in sandy loam soil at Horticultural Garden, Professor Jaya Shankar Telangana State Agriculture University, Rajendranagar, Hyderabad. To study the effect of seaweed extract on the growth parameters of carrots. The experiment was laid out in randomized block design (RBD) with eight treatments and replicated thrice. The treatments include various sources of biostimulants viz., Seaweed extract liquid, seaweed granules, vermicompost and vermiwash given as foliar application on three stages viz., first spray on 2-3 leaves stage and thereafter at every 20 days interval and as soil application twice at the time of sowing as well as 30 DAS.The various growth parameters were recorded. The results revealed that on application of RDF + soil application of seaweed extract twice at the time of sowing and at 30 DAS + foliar spray thrice 2.5 ml l-1 of water significantly increased the growth parameters viz., plant height, number of leaves per plant, chlorophyll content.
A Review of Advances on Natural Dye Sensitized Solar Cells (NDSSCs)
Authors: Alor K. P. , Ezekoye B. A. , Ugwuoke P. E. , Offiah S. U. , Ezema F. I. , Akor S. , Okafor I. F. , Ekechukwu O. V.
Published: November 2023

Currently, the situation of the economy is drastically affecting the growth and development of some growing nations with regard to the energy sector. Most developing countries still depend majorly on fossil fuels. Considering the environmental nuisance arising from the dangerous emissions from the combustion of fossil fuels and climate concerns, there is urgent need to seek other alternative energy sources to meet up with the global energy consumption demands as the human population is steadily on the increase. Energy from the sun is one of the most alternative sources that can be assessed freely as well as help in mitigating global climate change. Recent advances on dye sensitized solar cells (DSSC) using natural dyes is a welcome advancement for replacing high cost ruthenium dye. The application of natural dye for DSSC is due to their abundance in nature, low cost, simple and safe extraction from various natural resources without requiring complex synthetic procedures. Dye enhances the performance of a DSSC by providing the source of photo excited electrons. Recently, there has been research on areas that supports the exploration of different photoactive natural dyes. In this paper, we reviewed some natural dyes, energy conversion efficiencies of NDSSCs, methods of dye extraction, characterization and various fabrication techniques for improved DSSC performance from various researched articles. It was observed that there were variations in the recorded DSSCs performances and this can be attributed to steps employed by the researchers in the methods of dye extraction and DSSC fabrication.