bluuebunny/crossref_metadata_2025 huggingface dataset:
Distribution characteristics, source identification, and risk assessment of heavy metals in surface sediments of the salt lakes in the Ordos Plateau, China
Authors: Zhang Shengyin , Zhang Shuncun , Chen Yongxin , Chen Bo , Lei Tianzhu
Published: November 2021

Salt lakes have a significant effect on the regional climate, environment, and ecology in semi-arid regions characterized by lower rainfall and high evaporation. However, under the stresses of global change and human disturbance, anthropogenic pollution is the main factor threatening the lake ecological environment. Surface sediment samples collected from four salt lakes in the Ordos Plateau were used to investigate the salinity, concentration, pollution status, potential sources of heavy metals, and influencing factors. The surface sediments of Beida Pond and Gouchi Pond were weakly alkaline (pH < 9) owing to Na2SO4, whereas those of Chaigannaoer and Hongjiannao were strongly alkaline (pH > 9) owing to Na2CO3. The concentration range of Cr, Ni, Cu, Zn, As, Cd, and Pb in the sediment samples collected from the salt lake in the Ordos followed the order of Cr > Zn > Ni > Pb > Cu > As > Cd. The Cr values were higher in Chagannaoer and Hongjiannao, but the Ni, Cu, and Zn values were higher in Beida Pond and Gouchi Pond. The geoaccumulation index (Igeo) and enrichment factor (EF) consistently indicated that Cr posed the greatest potential ecological risk and that Ni, Cu, and Zn pollution was more severe in Beida Pond and Gouchi Pond than in Chagannaoer or Hongjiannao. However, Er and RI indicated these heavy metals were a low risk to the environment. Risk assessment code (RAC) revealed that Pb and Cr exhibited no mobility and had low potential bioavailability risk, although Zn, Ni, and As were categorized as medium risk. Cu had the highest mobility and high risk. Principal component analysis for Beida Pond and Gouchi Pond revealed that the source of Ni, Cu, Zn, Cd, and Pb might be associated with water - soluble elements in aqueous migration, and the source of Cr, Pb, and As might be lithospheric minerals carried by dust storms. Ni, Cu, Zn, Cd, Cr, and Pb in Chagannaoer and Hongjiannao may be derived from surface runoff, and chemicals from these sources may eventually accumulate in sediments. Pearson’s correlation analysis indicated that pH was the main environmental factor controlling the distribution of heavy metals in Chagannaoer and Hongjiannao .
Radiographic Evaluation of Congruency of the First Metatarsophalangeal Joint in Hallux Valgus
Authors: Li Yan , Tao Xu , Tang Kanglai
Published: November 2021

Background Congruency of the first metatarsophalangeal (MTP) joint is extremely important for the selection of surgical methods and prognosis, while radiographic evaluation methods are relatively lacking. The purpose of this article was to explore radiographic indicators for evaluating congruency of the first MTP joint.Methods Patients who had a weightbearing X-ray in the outpatient system were selected, excluding patients with trauma, deformity, and history of surgery. A total of 183 patients with 245 feet were included. The hallux valgus angle (HVA), distal metatarsal articular angle (DMAA), metatarsophalangeal joint angle (MTPJA), congruency index (CI) and tibial sesamoid position (TSP) were measured and statistically analysed.Results The higher the degree of hallux valgus was, the higher the proportion of incongruency of the first MTP joint. Significant differences were found in the DMAA, MTPJA and CI between the congruency and incongruency groups of patients with moderate to severe hallux valgus (P<0.05). The areas under the curve (AUCs) of the receiver operating characteristic (ROC) curve for the MTPJA and CI were 0.906 and 0.884, the sensitivity values reached 0.791 and 0.949, the specificity values were 0.862 and 0.644, and the critical values were 10.67 and 0.765, respectively. The correlation test indicated that in the congruency group, the DMAA and HVA were positively correlated, but the MTPJA, CI and HVA had low correlation coefficients. The DMAA and HVA were not correlated in the incongruency group, while the MTPJA and HVA were significantly positively correlated and the CI and HVA showed a negative correlation (P<0.05).Conclusion The MTPJA and CI are indicators that can be used to quantitatively evaluate the congruency of the first MTP joint, taking 10° and 0.765 as the demarcation points, respectively. Clinically, congruency of the MTP joint should be considered when choosing surgical methods for different degrees of hallux valgus, and the MTPJA and CI can be used as quantitative evaluation indicators.Level of evidence: Level III, Retrospective Comparative Study
Federated Synthetic Learning from Multi-institutional and Heterogeneous Medical Data
Authors: Chang Qi , Yan Zhennan , Qu Hui , Zhang Han , Baskaran Lohendran , Zhang Shaoting , Metaxas Dimitris
Published: November 2021

Statistically and information-wise adequate data plays a critical role in training a robust deep learning model. However, collecting sufficient medical data to train a centralized model is still challenging due to various constraints such as privacy regulations and security. In this work, we develop a novel privacy-preserving federated-discriminator GAN, named FedD-GAN, that can learn and synthesize high-quality and various medical images regardless of their type, from heterogeneous datasets residing in multiple data centers whose data cannot be transferred or shared. We trained and evaluated FedD-GAN on three essential classes of medical data, each involving different types of medical images: cardiac CTA, brain MRI, and histopathology. We show that the synthesized images using our method have better quality than using a standard federated learning method and are realistic and accurate enough to train accurate segmentation models in downstream tasks. The segmentation model trained on the synthetic data only is comparable to that trained on an all-in-one real-image dataset shared from multiple data centers if possible. FedD-GAN can learn to generate a scalable and diverse synthetic database without compromising data privacy. This synthetic database could help to boost machine learning techniques in medical data analytics.
Partially-Covered Fractal Induced Turbulence On Fins Thermal Dissipation
Authors: Chew Soon Hong , Hoi Su Min , Tran Manh-Vu , Foo Ji Jinn
Published: November 2021

The impacts of partially-covered fractal grids induced turbulence on the forced convective heat transfer across plate-fin heat sink at Reynolds number ReDh=22.0×103 were numerically and experimentally investigated. Results showed that partially covered grids rendered a higher thermal dissipation performance, with partially covered square fractal grid (PCSFG) registering an outstanding increase of 43% in Nusselt number relative to the no grid configuration. The analyzation via an in-house developed single particle tracking velocimetry (SPTV) system displayed the findings of unique “Turbulence Annulus” formation, which provided a small degree of predictivity in the periodic annulus oscillations. Further assessments on PCSFG revealed the preferred inter-fin flow dynamics of (i) high flow velocity, (ii) strong turbulence intensity, (iii) vigorous flow fluctuations, (iv) small turbulence length scale, and (v) heightened decelerated flow events. Furthermore, power spectra density unveiled the powerful vortex shedding effect, with PCSFG achieving fluctuation frequency f=18.5Hz close to an optimal magnitude. Such intricate flow structures pave the way for superior thermal transfer capabilities, benefiting the community in developing for higher efficiency heat transfer systems.
Development of a Cost of Illness Inventory Questionnaire for Children With Autism Spectrum Disorder in South Asia
Authors: Chaudhary Divya , Bhat Bhargav , Shields Gemma E , Davies Linda M , Green Jonathan , Verghis Tara , Roy Reetabrata , Kumar Divya , Kakra Minal , Vajaratkar Vivek , Lall Gitanjali , Pandey Sonakshi , Johri Sanchita , Shakeel Saani , Patel Vikram , Juneja Monica , Gulati Sheffali , Divan Gauri
Published: November 2021

Background

The economic burden of autism is substantial and includes a range of costs, including healthcare, education, productivity losses, informal care and respite care, among others. In India, approximately, 2 million children aged 2-9 years have autism. Given the likely substantial burden of illness and the need to identify effective and cost-effective interventions, this research aimed to produce a comprehensive cost of illness inventory (COII) suitable for children with autism in South Asia (India) to support future research.
Methods

A structured and iterative design process was followed to create the COII, including literature reviews, interviews with caregivers, pilot testing and translation. Across the development of the COII, thirty-two families were involved in the design and piloting of the tool. The COII was forward translated (from English to Hindi) and back translated. Each stage of the process of development of the COII resulted in the further refinement of the tool.
Results

Domains covered in the final COII include education, childcare, relocation, healthcare contacts (outpatient, inpatient, medical emergencies, investigations and medication), religious retreats and rituals, specialist equipment, workshops and training, special diet, support and care, certification, occupational adjustments and government rebates/schemes. Administration and completion of the COII determined it to be feasible to complete in 35 minutes by qualified and trained researchers. The final COII is hosted by REDCap Cloud and is a bilingual instrument (Hindi and English).
Conclusions

The COII was developed using experiences gathered from an iterative process in a metropolitan area within the context of one low- and middle-income country (LMIC) setting, India. Compared to COII tools used for children with autism in high-income country settings, additional domains were required, such as complimentary medication (e.g. religious retreats and homeopathy). The COII will allow future research to quantify the cost of illness of autism in India from a broad perspective and will support relevant economic evaluations. Understanding the process of developing the questionnaire will help researchers working in LMICs needing to adapt the current COII or developing similar questionnaires.
The Influence of Clinical Nurses' Empathy on their Death Competence: A Cross-Sectional Survey Study
Authors: Wang Jiahao , Chen Zhengying , Liu Yiting , Liao Xiaoli , Long Liuxin , Li Yamin
Published: November 2021

BackgroundEmpathy and death competence are important competences for clinical nurses. However, there is no clear consensus about what impact empathy has on death competency. Our study aimed to understand the status of the empathy and death competence of clinical nurses in China and to explore the effect of empathy on their competence.MethodsFor a survey conducted from May–June 2021, 1415 clinical nurses were selected by convenience sampling as the research objects. The Coping with Death Scale, the Jefferson Scale of Empathy—Health Professionals and a general information questionnaire designed by the researchers were used to investigate the status of the empathy and death competence of clinical nurses. The relationship between empathy and death competence was analysed by Pearson correlation, and the influence of the empathy of clinical nurses on their death competence was analysed by a hierarchical regression model.ResultPearson correlation analysis revealed that death competence was positively correlated with each dimension of empathy. Hierarchical regression model analysis revealed that after controlling for the influence of general information, nurses' empathy had a significant influence on their death competence, and this independently explained 5.8% of the variance in death competence.ConclusionsThe death competence of the clinical nurses in this sample was moderate to low level. Emotional nursing and transposition thinking are important influencing factors of death competence. Nursing managers should improve the empathy of clinical nurses to promote their death competence.
Isolation and Identification of a New Strain of Nervous Necrosis Virus from the Big-belly Seahorse Hippocampus Abdominalis in China
Authors: Chen Xinxin , Qi Jianfei , He Libin , Luo Huiyu , Lin Jinbo , Qiu Fengyan , Wang Qing , Zheng Leyun
Published: November 2021

Background: Betanodaviruses , members of the Nodaviridae family, are the causative agents of viral nervous necrosis (VNN) in fish, resulting in great economic losses worldwide. Methods: In this study, we isolated a virus strain named seahorse nervous necrosis virus (SHNNV) from cultured big-belly seahorses Hippocampus abdominalis in Xiamen city, Fujian Province, China. Cell isolation, PCR detection, phylogenetic analysis, qRT-PCR, fluorescence in situ hybridization (FISH) and histology were used for virus identification and analysis of virus histopathology. Furthermore, an artificial infection experiment was conducted for virulence testing. Results: Brain and eye tissue homogenates of diseased big-belly seahorses were inoculated onto a grouper spleen (GS) cell monolayer at 28°C. Tissue homogenates induced obvious cytopathic effects in GS cells. PCR and sequencing analyses revealed that the virus belonged to Betanodavirus and shared high sequence identity with red-spotted grouper nervous necrosis virus (RGNNV) isolates. qRT-PCR and fluorescence in situ hybridization revealed that SHNNV mainly attacked the brain and eye. Histopathological examination revealed that the virus led to cytoplasmic vacuolation in the brain and retinal tissues. Infection experiments confirmed that SHNNV was highly infectious, causing massive death in big-belly seahorses. Conclusion: A novel seahorse betanodavirus from the big-belly seahorse in China was discovered. This finding will contribute to the development of efficient strategies for disease management in aquaculture.
Spatiotemporal Regulation of The Bovine Oviduct Fluid Proteome Around The Time of Ovulation
Authors: Mahé Coline , Lavigne Régis , Com Emmanuelle , Pineau Charles , Locatelli Yann , Zlotkowska Aleksandra Maria , Almiñana Carmen , Tsikis Guillaume , Mermillod Pascal , Schoen Jennifer , Saint-Dizier Marie
Published: November 2021

Unraveling the oviduct fluid (OF) and its regulation is crucial to understand the microenvironment in which sperm capacitation, fertilization and early embryo development take place. Therefore, our aim was to determine the spatiotemporal changes in the OF proteome according to the anatomical region of the oviduct (ampulla vs. isthmus), the proximity of the ovulating ovary (ipsilateral vs. contralateral side) and the peri-ovulatory stage (pre-ovulatory or Pre-ov vs. post-ovulatory or Post-ov). Oviducts from adult cyclic cows were collected at a local slaughterhouse and pools of OF were analyzed by nanoLC-MS/MS and label-free protein quantification (n=32 OF pools for all region ´ stage ´ side conditions). A total of 3,760 proteins were identified in the OF, of which 37% were predicted to be secreted. The oviduct region was the major source of variation in protein abundance, followed by the proximity of the ovulating ovary and finally the peri-ovulatory stage. Differentially abundant proteins between regions, stages and sides were involved in a broad variety of biological functions, including protein binding, response to stress, cell-to-cell adhesion, calcium homeostasis and the immune system. This work highlights the dynamic regulation of oviduct secretions and provides new protein candidates for interactions between the maternal environment, the gametes and the early embryo.
Optimized Data-Independent Acquisition Approach for Proteomic Analysis at Single-Cell Level
Authors: Wang Yuefan , Lih T. Mamie , Chen Lijun , Xu Yuanwei , Kuczler Morgan , Cao Liwei , Pienta Kenneth , Amend Sarah , Zhang Hui
Published: November 2021

Single-cell proteomic analysis provides valuable insights into cellular heterogeneity allowing the characterization of the cellular microenvironment which is difficult to accomplish in bulk proteomic analysis. Currently, single-cell proteomic studies utilize data-dependent acquisition (DDA) mass spectrometry (MS) coupled with a TMT labelled carrier channel. Due to the extremely imbalanced MS signals among the carrier channel and other TMT reporter ions, the quantification is compromised. Thus, data-independent acquisition (DIA)-MS should be considered as an alternative approach towards single-cell proteomic study since it generates reproducible quantitative data. However, there are limited reports on the optimal workflow for DIA-MS-based single-cell analysis. Herein, we report an optimized DIA workflow for single-cell proteomics using Orbitrap Lumos Tribrid instrument. We utilized a breast cancer cell line (MDA-MB-231) and induced drug resistant polyaneuploid cancer cells (PACCs) to evaluate our established workflow. We found that a short LC gradient was preferable for peptides extracted from single cell level with less than 2 ng sample amount. The total number of co-searching peptide precursors was also critical for protein and peptide identifications at nano- and sub-nano-gram levels. Post-translationally modified peptides could be identified from a nano-gram level of peptides. Using the optimized workflow, up to 1,500 protein groups were identified from a single PACC corresponding to 0.2 ng of peptides. Furthermore, about 200 peptides with phosphorylation, acetylation, and ubiquitination were identified from global DIA analysis of 100 cisplatin resistant PACCs (20 ng). Finally, we used this optimized DIA approach to compare the whole proteome of MDA-MB-231 parental cells and induced PACCs at a single-cell level. We found the single-cell level comparison could reflect real protein expression changes and identify the protein copy number. Our results demonstrate that the optimized DIA pipeline can serve as a reliable quantitative tool for single-cell as well as sub-nano-gram proteomic analysis.
Calpain7 Negatively Regulates Human Endometrial Stromal Cell Decidualization in Endometriosis by Promoting FoxO1’s Phosphorylation and Nuclear Exclusion via Hydrolyzing AKT1
Authors: Kang Nannan , Shan Huizhi , Wang Junxia , Mei Jie , Jiang Yue , Zhou Jidong , Huang Chenyang , Zhang Hui , Zhang Mei , Zhen Xin , Yan Guijun , Sun Haixiang
Published: November 2021

Background

Endometrial receptivity damage caused by impaired decidualization may be one of the mechanisms of infertility in endometriosis (EMs). Our previous study demonstrated that Calpain-7 (CAPN7) is abnormally overexpressed in EMs. Whether CAPN7 affects the regulation of decidualization and by what mechanism CAPN7 regulates decidualization remains to be determined.
Methods

Immunohistochemistry (IHC) was used to assess the CAPN7 expression in human endometria. Quantitative real-time PCR (qRT-PCR), western blotting, ELIFA and ELISA were applied to explore PRL and IGFBP-1 expressions in decidualized human endometrial stromal cells (HESC). Immunofluorescence analysis and the nuclear and cytoplasmic protein extract assay were employed to test CAPN7’s affection on FoxO1’s location in HESC. Western blotting was used to explore the regulatory mechanism of CAPN7 to AKT1/FoxO1 signalling pathway.
Results

In this study, we found CAPN7 expression decreased during human endometrial stromal cell (HESC) decidualization in vitro. CAPN7 negatively regulated decidualization in vitro and in vivo. We also identified one conserved potential PEST sequence in the AKT1 protein and found that CAPN7 was able to hydrolyse AKT1 and enhance AKT1’s phosphorylation. Correspondingly, CAPN7 notably promoted the phosphorylation of Forkhead Box O1 (FoxO1), the downstream of AKT1 protein, at Ser319, leading to increased FoxO1 exclusion from nuclei and attenuated FoxO1 transcriptional activity in decidualized HESC. In addition, we detected endometrium CAPN7, p-AKT1 and p-FoxO1 expressions were increased in EMs.
Conclusions

These data demonstrate that CAPN7 negatively regulates HESC decidualization in EMs probably by promoting FoxO1’s phosphorylation and FoxO1 nuclear exclusion via hydrolyzing AKT1. The dysregulation of CAPN7 may be a novel cause of EMs.
Analysis of Soil Heavy Metal Pollution and Investigation of Dominant Plants in Abandon Gold Ming Area
Authors: Chen Rui , Han Lei , Liu Zhao , Zhao Yonghua , Chang Shanshan , Li Leshi , Li Risheng , Xia Longfei
Published: November 2021

In recent years, environmental pollution and ecological destruction in mining area has seriously affected the health and survival of surrounding people. To explore the degree of heavy metal pollution in soil of mining areas and phytoremediation strategies, we chose soil and dominant plants in an abandoned gold mining area as the research object. In this study, Arsenic (As) content in soil and plants was measured. The As pollution degree in local areas was evaluated by using geo-accumulation index and potential ecological risk index. And, As content in plants was analyzed by using enrichment coefficient method. The results show that 1) The pulp deposition area has the most serious As pollution of soil and the largest potential ecological risk index. 2) The composition of the plant community in the study area is dominated by herbaceous plants, among which gramineous, composites and legumes are the dominant plant types in the vegetation community restoration in the mining area. 3) The geoaccumulation index is significantly negatively correlated with species diversity index, Shannon-wiener diversity index and Pielou species evenness index. 4) The As content in dominant plants ranges from 0.11 to 15.92 mg/kg. The plants with strong As enrichment ability are Erigeron annuus (L.) Pers., Periploca sepium Bunge, and Setaria viridis (L.) Beauv., which can be considered as As-tolerant plants. This study can provide a basis and reference for plant management of As pollution in local soil.
Untapped power of food system by-products to increase global food supply
Authors: Sandström Vilma , Chrysafi Anna , Lamminen Marjukka , Troell Max , Jalava Mika , Piipponen Johannes , Siebert Stefan , Hal Ollie van , Virkki Vili , Kummu Matti
Published: November 2021

Many animal feeds compete for resources with human food production. The current use of food system by-products and residues as feed could potentially be increased to reduce the competition. We gathered a harmonised global food system material flow database for crop, livestock and aquaculture production including the availability of food system by-products. This allowed us to analyse the potential to replace the food-competing feedstuff, here cereals, whole fish, vegetable oils and pulses, that currently account for 11% of total feed used globally, with available food system by-products. While considering the nutritional requirements in animal production, we found that the replacement could free food-grade feeds for human consumption and increase the current food supply in kcal by 11-17% (6-11% if the use of crop residues is not accounted for) and in terms of protein 11-15% (9-14%). Our results thus indicate that the increased feed use of by-products has considerable potential, particularly when used in combination with other measures, in the much needed transition towards more sustainable and circular food systems.
The Linkage between Urban Built-up and Surface Water Quality: Inferences from the Parts of Karamana River Basin, Thiruvananthapuram, Kerala, India
Authors: AbdulKhader Mohammed-Aslam Mohammad , Rema Reshma Sisupalan
Published: November 2021

The linkage between the land use/land cover (LULC) pattern and water quality is an emerging topic in multidisciplinary research. The LULC changes affect water quality in many ways. Change in the land use/land cover, especially urbanization leads to water quality deterioration. This study mainly focuses on the water quality in parts of the river Karamana, which flows through the Thiruvananthapuram urban area. The water quality parameters of six selected sites within the urban area were obtained. Physico-chemical and biological parameters of water quality were analysed for 2019 (pre-monsoon, monsoon, and post-monsoon). The water quality data obtained during the present study were used to characterize the built-up and other areas. Results have shown a distinct variation of parameters in the upstream region (less built-up) than that of the urban area (more built-up). The results have clearly demonstrated the indication of the effect of urbanization on water resources. The speedy development of urban built-up in Thiruvananthapuram city causing severe issues to the water regime in terms of its quality. The data shows that the water quality is poor in the pre-monsoon period in most of the areas. Though the worsening of water quality is limited to a few localized zones, the trend of the quality change is serious. It needs the attention and proper consideration of policy planners and decision-makers. Adequate effluent treatment facilities in the urban regions is the need of the hour to minimize pollution.
A Cross-Sectional Study On The Acceptance Of COVID-19 Vaccine
Authors: Adeniran Adetayo Olaniyi , Tayo-Ladega Oluwadamisi , Abdullahi Taye Mohammed
Published: November 2021

Background

Studies on the level of acceptance of COVID-19 vaccines and the perception of COVID-19 were most prevalent in the developed countries while scarcity of such studies in developing countries and Nigeria in particular. Because the level of acceptance of COVID-19 vaccines and the perception of COVID-19 differs among citizens of different countries, this study examines the acceptance of Nigerians to the usage of the COVID-19 vaccine.
Methods

An online cross-sectional study was conducted, with the use of an e-questionnaire which was administered to respondents (Nigerians) in a form of an online survey with emphasis on COVID-19 vaccine acceptance. Logistic regression analysis was employed to achieve the study.
Conclusions

The Nigerian public COVID-19 vaccines acceptance was fairly low in Nigeria. The educated male respondents are most likely to accept the usage of the vaccine. Similarly, respondents who believed that vaccines are generally safe and those who were willing to pay for vaccines, after becoming widespread, were more likely to accept the COVID-19 vaccines. However, those above 35 years old and respondents who are employed were not likely to accept the vaccines except been mandated by the employers. Moreover, respondents that believed in the rumors surrounding the dynamics of COVID-19 as well as those that do not have assurance in any source of information regarding COVID-19 vaccines, may not accept the usage of the vaccine. This study found that the most reliable sources of information regarding the COVID-19 vaccines were reports from the media and reports from healthcare providers.
TMAO Stimulate Inflammation and Lipid Accumulation via NF-κB Signaling Pathway in Nonalcoholic Fatty Liver Disease
Authors: chen zhijun , Zhang Jiale , Cheng Qian , Cai Xiangsheng , Xie RuiTian , Liu TeBin , Wang XiaoDong , Cai JieNa
Published: November 2021

Background Nonalcoholic fatty liver disease (NAFLD) is a common disease and it is commonly associated with obesity. Trimethylamine N-oxide (TMAO) is a metabolite of intestinal flora generated in liver by flavin-containing monooxygenase 3 (FMO3), which has been widely studied in cardiovascular diseases and obesity. However, the mechanism of TMAO reacted on liver remains unclear. This study aimed to determine TMAO activated hepatitis inflammation and lipid accumulation which was associated with nuclear factor kappa B (NF-κB) signaling pathway in vitro. ResultsThe present study showed that TMAO in 50μM markedly increased the LO2 cells function and decreased the cells inflammation. However, over the concentration of 200μM in TMAO, cells inflammation was increased and function was declined apparently. In addition, TMAO promoted lipid accumulation. Mechanistically, this change was accompanied by the activation of NF-κB signaling pathway. Furthermore, blocking NF-κB by SN50 was significantly increased in lipid accumulation and apoptosis. SN50 was markedly decreased the protein expression stimulating by TMAO.ConclusionsOverall, the result suggested that TMAO promotes cells inflammation and lipid accumulation in hepatocytes and it might be associated with NF-κB signaling pathway.
Eutrophication Factor Analysis Using Carlson Trophic State Index (CTSI) Towards Non-Algal Impact Reservoirs in Taiwan
Authors: Lin Jr-Lin , Karangan Arthur , Huang Ying Min , Kang Shyh-Fang
Published: November 2021

Carlson trophic state index (CTSI) has been commonly adopted to assess the eutrophication potential of reservoirs or lakes in water quality management. This study aims to analyze the influencing factors of CTSI-based eutrophication by using Pearson correlation analysis and principal component analysis (PCA) with long-term data from 2008 to 2019 on 21 drinking water reservoirs in Taiwan. The trophic state index (TSI) deviation indicates that most drinking water reservoirs in Taiwan, around 45.5% of statistical data fall into non-algal turbidity with surplus phosphorus, especially in the spring and winter season. Besides, there are about 78 % of total collected data show that TSI (Chl-a) is less than TSI (SD) due to the small particulate predominance. On the other hand, three TSI variables (Secchi depth (SD), total phosphorus (TP) and chlorophyll-a (Chl-a)) of CTSI exhibits insignificant correlation to each other in most cases. At such a condition, the probability of eutrophication (TSI>50) based on TSI (SD) is 63%, while it is only as low as 20% based on TSI (TP) and TSI (Chl-a). The influencing factors of eutrophication variables by suspended solids (SS) composition and turbidity have shown that the SD is strongly influenced by non-algal SS. The deviations of three TSI have shown that the highest algae-induced eutrophication potential occurs in the summer season. In addition, the TP is the most significant loading factor of algae-induced eutrophication for drinking water reservoirs. It is concluded that the CTSI has limited applicability to identify the trophic status of drinking water reservoirs in Taiwan in the presence of sustainable non-algal turbidity comparative Chl-a that completely represents algal growth potential (AGP).
Higher-Order Semimetals and Chiral Hinge States in Topolectrical Circuit Model
Authors: Rafi-Ul-Islam S M , Siu Zhuo Bin , Jalil Mansoor
Published: November 2021

We propose a 3D topolectrical (TE) network that can be tuned to realize various higher-order topological gapless and chiral phases. We first study a higher-order Dirac semimetal phase that exhibits a hinge-like Fermi arc linking the Dirac points. This circuit can be extended to host highly tunable first- and second-order Weyl semimetals phases by introducing a non-reciprocal resistive coupling in the x − y plane that breaks time reversal symmetry. The first- and second-order Weyl points are connected by zero-admittance surface and hinge states, respectively. We also study the emergence of first- and second-order chiral modes induced by resistive couplings between similar nodes in the z-direction. These modes respectively occur in the midgap of the surface and hinge admittance bands in our circuit model without the need for any external magnetic field.
Effect of Changes in the Posterior Tibial Slope on Femorotibial Articular Contact Kinematics after Cruciate-Retaining Total Knee Arthroplasty: Do the Changes Affect Outcomes?
Authors: pan xiqing , li feng , liu jinhui , zhang jiangli , chai an , shu lei , li yao
Published: November 2021

Background

Total knee arthroplasty (TKA) outcomes are affected by many factors.This study aimed to evaluate whether changes in the posterior tibial slope (PTS) affects patients’ outcomes after cruciate-retaining TKA by affecting femorotibial articular contact kinematics.
Methods

Altogether, 20 knees in 10 patients who underwent posterior cruciate ligament-retaining TKA using the same size prosthesis for medial osteoarthritis were assessed preoperatively and 1 year postoperatively. PTS changes seen on lateral radiographs before and after TKA were calculated. Knees were placed in groups according to the PTS change at 1 year postoperatively (preoperative value − postoperative value). Group 1 had a >3° change and group 2 a ≤3° change. Knee kinematics under the weight-bearing mid-flexion condition were compared between the two groups via two-dimensional/three-dimensional registration. Pain was measured using the visual analog scale, and knee function was based on the Western Ontario and McMaster universities (WOMAC) osteoarthritis index and Knee Society Score (KSS) questionnaire results.
Results

Group 2 experienced paradoxical anterior motion of the mediofemoral condyle postoperatively, whereas group 1 did not. Comparison of TKA results between the two groups showed a significant between-group difference in pain and knee function of the KSS and in the WOMAC osteoarthritis index score (P ≤ 0.05). Postoperative results were better in group 1 than in group 2.
Conclusions

Achieving a greater change in the posterior tibial slope apparently improves outcomes in patients undergoing posterior cruciate ligament-retaining TKA because it reduces the paradoxical medial femoral condylar movement.
Unusual case report of an adenomatoid odontogenic tumor in the mandible: 3-years of follow-up
Authors: Andreis Jéssica Daniela , Gross Dayane Jaqueline , Fischborn Amanda Regina , Mecca Leomar Emanuel Almeida , Rosa Chioca Lea , Zanelato Cristina Maria de Freitas , Claudino Marcela , Lúcio Fernandes Tito , Franco Gilson Cesar Nobre
Published: November 2021

This case report showed an AOT in a 12-year-old female patient referred for orthodontic-surgical of both impacted right mandibular canine and lateral incisor. Cone beam computed tomography revealed a well-defined mixed hyperdense/hypodense lesion, involving the crown of the mandibular lateral incisor. The surgery consisted in surgical exposure of the mandibular right canine and lateral incisor, bonding of the lateral incisor for orthodontic traction and curettage of the mandibular lesion. Histopathological examination revealed several columnar epithelial cells with minimal stromal connective tissue, lobular pattern and rosettes and duct-like structures, confirming the diagnosis of AOT. After, the patient was referred for orthodontic traction of the impacted teeth. At 1 and 3-year postoperatively, follow-ups examinations showed extensive bone repair, resolution of the tooth-retention and absence of recurrence. Although AOT is an uncommon lesion in the mandible, it should be considered in the differential diagnosis of the mixed profile lesions in this region.
Lesiones quísticas sincrónicas en los maxilares: reporte de casos
Authors: Curi Marcos Martins , Koga Daniel Henrique , Condezo Anthony Froes Benites , Costa Beethoven Estevão , Silveira Heitor Albergoni da , Cardoso Camila Lopes
Published: November 2021

La asociación de lesiones odontogenéticas afectando los huesos maxilares en un mismo paciente, es raro. El objetivo de este trabajo fue relatar dos casos de lesiones sincrónicas, afectando a un mismo paciente. En el primer caso, el paciente presentó un queratoquiste odontogénico en la mandíbula y un quiste del conducto nasopalatino, y en el segundo caso, el paciente presentó un ameloblastoma en la mandíbula y un quiste del conducto nasopalatino. Ambos casos fueron tratados a través de la remoción total de las lesiones, microscopicamente revelaron los respectivos diagnósticos y ahora estan siendo controlados, con la ausencia de recidivas después de cuatro años.
Optimizing body design of a computer-assisted manual press
Authors: M. Turof
Published: November 2021

This paper proposes a simplified design of a press body manually using a model consisting of a double symmetrical frame flush. Both Mathcad and Solidworks programs were used to determine the dimensions and drawings. MathCad is a very complex program, but also very useful for engineers, researchers, mathematicians, students, teachers, and all those who use math. Mathcad is a much better way to perform and manage engineering calculations, making them easy to achieve, understand, verify, communicate, and logically follow. SolidWorks is a solid modeling computer-aided design (CAD) and computer-aided engineering (CAE) computer program that runs on Microsoft Windows.
River, lake and sea traffic safety issues regarding waste generated during disasters
Authors: G. Károly
Published: November 2021

This publication present questions related to river and sea traffic safety and waste management in disaster situations taking into consideration domestic and international waste management policies, river and sea transport industry recommendations, instructions, and provisions. The principal objective is to examine how applicable are the technical security solutions and regulations to enhance safe and efficient waste management to meet of today's challenges.
Numerical analysis of the flow around a cylinder for the perspective of correlations of the drag coefficient of the ship’s hulls
Authors: T. Baracu
Published: November 2021

The flow around cylinder open the path for studying more complex shape bodies like the ship’s hulls. The hydrodynamic properties of the ship’s hulls can be decomposed as combinations of the flow properties of simpler bodies like flat plates, cylinders, ellipses, spheres and ellipsoids. The aim of this study is to describe the flow around a cylinder based on simulations with platforms like Comsol and Ansys that further can be compared with experimental and analytical results. The drag force caused by the flow around cylinders can be combined with the drag force of simple elements like flat plates, ellipses in order to correlate with the drag force of a specific hull of ship. Cylinder is a case that offers with its simplicity the possibility to check the results in all three ways: analytical, computational and experimental. An exhaustive analysis of this shape offers a beginning path for generalizing the external flows like the application of the superposition theory for complex geometries.
Aspects regarding the acoustics of a lecture hall
Authors: T. Pazara
Published: November 2021

In a lecture hall it is vital to assure proper teaching conditions meaning that the information from the speaker/teacher must be received correctly by the listeners. Speech intelligibility is the main objective when a lecture hall is evaluated. In this paper, the authors discuss the importance of the acoustics of a lecture hall and the influence of various parameters over speech transmission from the speaker – the professors to the listeners – the students. The number of acoustical parameters is very large, but Speech Transmission Index (STI) and Reverberation Time (RT) are commonly used to evaluate the acoustics of a teaching room. Other parameters like room geometry and seat placement have great influence in speech intelligibility. As an example, a lecture hall of 120 seats from Naval Academy „Mircea cel Batran“ is investigated using virtual simulations with ODEON software. The results of the simulations are discussed and some remarks are made regarding the current condition of the lecture hall.
Testing of immunity to electrostatic discharge of electronic devices and devices electrically initiated
Authors: I. Ciocioi
Published: November 2021

Electrostatic discharges of bodies loaded with static electricity are accompanied by the emergence of tension and transient currents, which can cause damage to electronic devices and the ignition of electrically initiated devices. In electromagnetic compatibility a great importance (from the point of view of electrostatic discharge) has the discharge of human body.
Original article Neotectonic formation and localization conditions of groundwater reserves in over-deepened sections of the Kitoy River valley
Authors: Kuranicheva A. I. , Lankin Yu. K. , Naumova O. O.
Published: November 2021

The purpose of the study is to identify the main neotectonic formation features of over-deepened valleys where fresh groundwater is localized. The object and the subject of the study is the Kitoy deposit of drinking groundwater located in the U-shape valley of the Kitoy river, which is composed of constratal alluvium, as well as hydrogeological and hydrogeochemical conditions of the deposit. The study of the over-deepened alluvial dislocation is carried out based on the analysis of the works performed at the Kitoy fresh groundwater deposit for the period from 1956 to 2020. The deposit is located at the southern margin of the Siberian platform within the Irkutsk-Cheremkhovo plain. The article studies the origin of the dislocation formed by the intersection of waves of pitching and subsidence of the Baikal and Sayan directions accompanied by the groundwater localization. The described over-deepened valley is 9-39 m thick. It is represented by boulder-gravelpebble material with sandy aggregate. The average filtration coefficient for the deposit is 122 m/day, the average water permeability coefficient is 3400 m2 /day, whereas beyond its limits the indicators decrease. The qualitative composition of groundwater meets the standards, but some areas feature increased mineralization, high content of iron and manganese due to the inflow of groundwater from the underlying Jurassic aquifers. The authors made a generalization on the variations of the effective thickness of the aquifer and analyzed the favorable conditions for the formation of fresh groundwater within the depression structure for the purpose of water supply for drinking and household uses.
Connecting with Deities: The Practice of Spirit Mediumship among the Chinese in Kuantan, Pahang
Authors: Foo Melvin Bok Yee , Chai Elena
Published: November 2021

The belief towards the spirit medium is one of the oldest beliefs in Chinese folk religion. This research explored spirit mediumship practices among the Chinese in Kuantan, Pahang, and interviewed 10 spirit mediums by applying interpretive phenomenological analysis. The findings indicate that the ability to interact with deities is either due to unavoidable illness, hereditary, naturally acquired, or learned. Indeed, a spirit medium may or may not convey messages to the audience or the deities from ritual performances. However, the ritual had revealed an “indispensable and official” status among mediums and worshippers. Although some expectations of this practice have faded due to modernity, it is still popular among the Chinese, especially in bonding the Chinese together as one community.
THE REGULATION URGENCY OF CHILDREN UNDER 12 (TWELVE) YEARS OLD IN THE ACT OF JUVENILE JUSTICE SYSTEM IN INDONESIA
Authors:   Doctoral Program in Law Students of Brawijaya University, Malang., Iswahyudi Eko , Nyoman Nurjaya I. ,   Doctoral Program in Law Lecturers of Brawijaya University, Malang., Aprilianda Nurini ,   Doctoral Program in Law Lecturers of Brawijaya University, Malang., Sugiri Bambang ,   Doctoral Program in Law Lecturers of Brawijaya University, Malang.
Published: October 2021

In the Act No. 11 of 2012 about the Juvenile Criminal Justice System, it explains the age limit for juvenile criminal responsibility for those who commit criminal acts, as regulated in Article 1 point 3. The children between 12 (twelve) years old and 18 (eighteen) years old are suspected of committing a crime.. The purpose of this study was to determine and analyze the urgency of regulating teenager under the age of 12 in the constitution of Republic of Indonesia Number 11 of 2021 on the Juvenile Criminal Justice System as well as children in conflict with the law.This type of normative legal research uses a statute approach and a case approach through a literature study. The results of the research on the urgency of regulating children under the age of 12 in Act Number 11 of 2021 concerning the Juvenile Criminal Justice System as well as children in conflict with the law. Many cases of crime that occur under the age of 12 years. So that special attention is needed regarding the minimum age limit for children who can be given criminal sanctions related to Article 1 letter 3 and Article 21 paragraph 1 of Act Number 11 of 2021 about the Juvenile Criminal Justice System without ignoring the psychological aspects of the child, whether acting as perpetrators, witnesses or victims. The purpose of punishing children is relatively not just to retaliate against people who commit criminal acts but has a useful purpose.
EFFET DE LA DATE DE SEMIS ET DE LA FERTILISATION SUR LA PHENOLOGIE ET LES PARAMETRES DE CROISSANCE DUNE VARIETE PRECOCE DE MIL A KORHOGO, CENTRE-NORD DE LA COTE DIVOIRE
Authors:   UFR Des Sciences Biologiques / Departement De Biologie Vegetale, Universite Peleforo Gon Coulibaly, Korhogo., Mohamed Sahabane Traore , Mohamed Doumbouya ,   UFR Des Sciences Biologiques / Departement De Biologie Vegetale, Universite Peleforo Gon Coulibaly, Korhogo., Laope Ambroise Casimir Siene ,   UFR Des Sciences Biologiques / Departement De Biologie Vegetale, Universite Peleforo Gon Coulibaly, Korhogo., Lacina Fanlegue Coulibaly ,   UFR Des Sciences Biologiques / Departement De Biologie Vegetale, Universite Peleforo Gon Coulibaly, Korhogo., Tah Valentin Felix Nguettia ,   UFR Des Sciences Biologiques / Departement De Biologie Vegetale, Universite Peleforo Gon Coulibaly, Korhogo., Mariame Conde ,   UFR Des Sciences Biologiques / Departement De Biologie Vegetale, Universite Peleforo Gon Coulibaly, Korhogo., Bosse Jean-Marc Drogba ,   UFR Des Sciences Biologiques / Departement De Biologie Vegetale, Universite Peleforo Gon Coulibaly, Korhogo., Ange Fabrice Bera Kouadio ,   UFR Des Sciences Biologiques / Departement De Biologie Vegetale, Universite Peleforo Gon Coulibaly, Korhogo.
Published: October 2021

Notre etude realisee sur le mil (Pennisetumglaucum(L.) R. Br.), au Centre-Nord de la Cote dIvoire, avait pour objectif de determinerles effets de la date de semis et de la fertilisation sur la phenologie et les parametres de croissance dune variete precoce de mil. Deuxessaisontete mis en place selonundispositifexperimentalconstitue de blocs completsrandomises, a trois repetitions. Le facteur principal, la fertilisation a cinq niveaux (NPK [15-15-15 + 6S + 1B]) :fiente de poulet, dejections de lapin et de bÅ“uf, temoin {Sans apport dengrais}). Les observations ontporte, essentiellement, sur la phenologie et les parametres de croissance. Par ailleurs les quantites de pluiestombees au cours de lexperimentationonteteenregistrees. Nos resultatsontmontre que la phenologie a eteinfluencee par les differentes dates de semis combinees a lutilisation des fumures. La fiente de poulet par rapport au temoin, a favoriseunereduction des delais de floraison et de durees de cycle au premier semis. Au second semis, la duree de cesdifferentsstades, a etereduitepar la dejection de lapin. Il ressort un raccourcissement de cesdelais au semis 1 comparativement a la date de semis 2. Ence qui concerne les parametres de croissance, la fumuremineralesestrevelee plus efficace. De plus, la croissance a etemeilleure a la premiere date de semis qua la seconde date.