bluuebunny/crossref_metadata_2025 huggingface dataset:
The world’s first glyphosate-resistant case of Avena fatua L. and Avena sterilis ssp. ludoviciana (Durieu) Gillet & Magne and alternative herbicide options for their control
Authors: Chauhan Bhagirath Singh
Published: January 2022

Avena fatua and A. ludoviciana (commonly known as wild oats) are the most problematic winter grass species in fallows and winter crops in the northeast region of Australia. A series of experiments were conducted to evaluate the performance of glyphosate and alternative post-emergence herbicides on A. fatua and A. ludoviciana. This study reports the world’s first glyphosate-resistant (GR) biotypes of A. fatua and A. ludoviciana. The glyphosate dose required to kill 50% of the plants (LD50) and to reduce 50% of the biomass (GR50) for the GR biotype of A. fatua was 556 g a.e./ha and 351 g a.e./ha, respectively. These values for A. ludoviciana were 848 g a.e./ha and 289 g a.e./ha. Regardless of the growth stage (3–4 or 6–7 leaf stages), clethodim (120 g a.i./ha), haloxyfop (78 g a.i./ha), pinoxaden (20 g a.i./ha), and propaquizafop (30 g a.i./ha) were the best alternative herbicide options for the control of A. fatua and A. ludoviciana. The efficacy of butroxydim (45 g a.i./ha), clodinafop (120 g a.i./ha), imazamox + imazapyr (36 g a.i./ha), and paraquat (600 g a.i./ha) reduced at the advanced growth stage. Glufosinate (750 g a.i./ha), flamprop (225 g a.i./ha), and pyroxsulam + halauxifen (20 g a.i./ha) did not provide effective control of Avena species. This study identified alternative herbicide options to manage GR biotypes of A. fatua and A. ludoviciana.
Improving the accessibility to public schools in urban areas of developing countries through a location model and an analytical framework
Authors: de Armas Jesica , Ramalhinho Helena , Reynal-Querol Marta
Published: January 2022

The location of primary public schools in urban areas of developing countries is the focus of this study. In such areas, new schools and modification of the current schools are required, and this process should be developed using rational and broad supporting tools for decision makers, such as optimization models. We propose a realistic coverage location model and a framework to analyze the location of schools. Our approach considers the existing schools and their resizing, the best locations of the new schools that may have different capacities, population coverage, walking distances and budget provisions for building and updating schools. As a case study, we assess the current primary school network in Ciudad Benito Juarez to provide managerial insights. Through the proposed framework, we analyze the current locations of schools and decisions to be made by considering future scenarios in different time periods. The proposed model is quite flexible and easy to adapt to new considerations, allowing it to be applied to regions in developing countries under similar conditions.
The mental health of university students during the COVID-19 pandemic: An online survey in the UK
Authors: Chen Tianhua , Lucock Mike
Published: January 2022

Higher education students’ mental health has been a growing concern in recent years even before the COVID-19 pandemic. The stresses and restrictions associated with the pandemic have put university students at greater risk of developing mental health issues, which may significantly impair their academic success, social interactions and their future career and personal opportunities. This paper aimed to understand the mental health status of University students at an early stage in the pandemic and to investigate factors associated with higher levels of distress. An online survey including demographics, lifestyle/living situations, brief mental well-being history, questions relating to COVID-19 and standardised measures of depression, anxiety, resilience and quality of life was completed by 1173 students at one University in the North of England. We found high levels of anxiety and depression, with more than 50% experiencing levels above the clinical cut offs, and females scoring significantly higher than males. The survey also suggested relatively low levels of resilience which we attribute to restrictions and isolation which reduced the opportunities to engage in helpful coping strategies and activities rather than enduring personality characteristics. Higher levels of distress were associated with lower levels of exercising, higher levels of tobacco use, and a number of life events associated with the pandemic and lockdown, such as cancelled events, worsening in personal relationships and financial concerns. We discuss the importance of longer-term monitoring and mental health support for university students.
‘Esta es la España de Franco’: Los años cincuenta del franquismo (1951–1959), Miguel Ángel del Arco Blanco and Claudio Hernández Burgos (eds) (2020)
Authors: Cleminson Richard
Published: January 2022

Review of: ‘Esta es la España de Franco’: Los años cincuenta del franquismo (1951–1959), Miguel Ángel del Arco Blanco and Claudio Hernández Burgos (eds) (2020)

Zaragoza: Prensas de la Universidad de Zaragoza, 368 pp.,

ISBN 978-8-41340-110-2, pbk, €21.15
Pengantar Tekstur Kristalografi: Teori dan Aplikasi
Authors:   Indonesian Institute of Sciences, Pramono Andika , Bouffette Jenny ,   Ecole National d’Ingénieur Tarbes (ENIT) - France
Published: January 2022

Analisis dan kajian tekstur kristalografi diperlukan untuk mengetahui serta memahami anisotropi sifat suatu senyawa, material, produk, atau komponen sebagai hasil dari tahapan proses, manufaktur, atau sintesis. Bidang ilmu yang membutuhkan investigasi tekstur kristalografi tidak hanya terbatas pada bidang ilmu metalurgi dan material, tetapi bisa juga bidang lainnya, seperti bidang hayati, bahkan sosial kemasyarakatan. Buku ini bertujuan memberi pemahaman secara efektif dan efisien kepada pembaca tentang tekstur kristalografi beserta aplikasinya serta menjadi pedoman tentang sistematika berpikir dalam mengkaji dan menganalisis problematika tekstur kristalografi. Selain itu, di dalam buku ini juga terdapat beberapa contoh aplikasi tekstur kristalografi di berbagai bidang untuk memberikan gambaran dan sense kepada para pembaca sehingga siap untuk mengimplementasikannya di bidang masing-masing. Pada masa mendatang, pemahaman terhadap investigasi dan analisis tekstur kristalografi serta penggunaannya di bidang penelitian, perekayasaan, dunia pendidikan tinggi, serta industri di Indonesia diharapkan dapat meningkat. Untuk itu, semoga buku ini bermanfaat serta dapat membuka cakrawala baru tentang tekstur kristalografi di Indonesia.
A double phase equation with convection
Authors: Liu Zhenhai , Papageorgiou Nikolaos
Published: January 2022

We consider a double phase problem with a gradient dependent
reaction (convection). Using the theory of nonlinear operators of monotone
type, we show the existence of a nontrivial, positive, bounded solution.
Pullback attractor for a nonlocal discrete nonlinear Schrödinger
equation with delays
Authors: Pereira Jardel
Published: January 2022

We consider a nonlocal discrete nonlinear Schrödinger equation with
delays. We prove that the process associated with the non-autonomous model
possesses a pullback attractor. As a consequence of our discussion, the
existence of a global attractor for the autonomous model is derived.
Solitary waves for a fractional Klein–Gordon–Maxwell equations
Authors: Zhang Xin
Published: January 2022

We investigate existence of solutions for a fractional Klein–Gordon
coupled with Maxwell's equation. On the basis of overcoming the lack of
compactness, we obtain that there is a radially symmetric solution for the
critical system by means of variational methods.
Esophageal Perforation Successfully Treated With EVT
Authors: Panneerselvam Kavea , Samuel Ronald , Sealock Robert J.
Published: January 2022

Esophageal perforation is rare and carries high morbidity and mortality. A high degree of suspicion is needed for timely diagnosis and treatment. A 54-year-old man presented with fever and confusion. Imaging revealed air in the hepatic inferior vena cava and concern for a fistula between the distal esophagus and the inferior vena cava. An upper endoscopic evaluation revealed a dental floss pick penetrating the distal esophagus. The foreign body was removed, and endoluminal vacuum therapy was used to close the perforation. Endoluminal vacuum therapy is an emerging therapy to treat full-thickness gastrointestinal injuries.
Artificial Intelligence for Detecting and Delineating Margins of Early ESCC Under WLI Endoscopy
Authors: Liu Wei , Yuan Xianglei , Guo Linjie , Pan Feng , Wu Chuncheng , Sun Zhongshang , Tian Feng , Yuan Cong , Zhang Wanhong , Bai Shuai , Feng Jing , Hu Yanxing , Hu Bing
Published: January 2022

INTRODUCTION:

Conventional white light imaging (WLI) endoscopy is the most common screening technique used for detecting early esophageal squamous cell carcinoma (ESCC). Nevertheless, it is difficult to detect and delineate margins of early ESCC using WLI endoscopy. This study aimed to develop an artificial intelligence (AI) model to detect and delineate margins of early ESCC under WLI endoscopy.

METHODS:

A total of 13,083 WLI images from 1,239 patients were used to train and test the AI model. To evaluate the detection performance of the model, 1,479 images and 563 images were used as internal and external validation data sets, respectively. For assessing the delineation performance of the model, 1,114 images and 211 images were used as internal and external validation data sets, respectively. In addition, 216 images were used to compare the delineation performance between the model and endoscopists.

RESULTS:

The model showed an accuracy of 85.7% and 84.5% in detecting lesions in internal and external validation, respectively. For delineating margins, the model achieved an accuracy of 93.4% and 95.7% in the internal and external validation, respectively, under an overlap ratio of 0.60. The accuracy of the model, senior endoscopists, and expert endoscopists in delineating margins were 98.1%, 78.6%, and 95.3%, respectively. The proposed model achieved similar delineating performance compared with that of expert endoscopists but superior to senior endoscopists.

DISCUSSION:

We successfully developed an AI model, which can be used to accurately detect early ESCC and delineate the margins of the lesions under WLI endoscopy.
Sporadic primary hyperparathyroidism with multiple parathyroid adenomas
Authors: Bibik E. E. , Eremkina A. K. , Knyazeva O. A. , Mokrysheva N. G.
Published: January 2022

Multiple lesions of the parathyroid glands (PTG) in primary hyperparathyroidism (PHPT) can be sporadic or develop as part of hereditary syndromes, manifesting at young age. There the description of a severe sporadic PHPT with big parathyroid neoplasms in the young patient is presented. Clinical data made it possible to suspect MEN-1 syndrome or parathyroid carcinomas; however, mutations CDKN, CDC73, MEN1 were excluded. The patient underwent removal of three identified tumors: benign adenomas of the left PTG and hyperplasia of the right one. Postoperative hypocalcemia and severe hungry bone syndrome required the administration of vitamin D and calcium carbonate preparations. However, a year after the operation, a «mild» recurrent disease was confirmed. Taking into account the patient’s refusal to reoperation and a significant improvement of the target organs state, active observation was continued. The patient needs further careful dynamic monitoring by specialists in order to timely identify indications for repeated surgical treatment to improve the life quality and span.
Morphological characteristics of pituitary adenomas in the phenocopy of multiple endocrine neoplasia type 1
Authors: Trukhina D. A. , Mamedova E. O. , Lapshina A. M. , Vasilyev E. V. , Tiulpakov A. N. , Belaya Zh. E.
Published: January 2022

BACKGROUND: Multiple endocrine neoplasia type 1 (MEN 1) is a rare autosomal dominant disorder caused by mutations in the MEN1 gene, which encodes the menin protein. If a patient has the MEN 1 phenotype in the absence of mutations in the MEN1 gene, the condition is classified as a phenocopy of this syndrome. Although significant progress has been made in understanding the function of menin, its role in the oncogenesis of the endocrine glands is still being elucidated. Due to its key role in physiological and pathological processes, the assessment of the menin expression can provide valuable information.

AIM: to determine whether there are any differences in the expression of menin in the pituitary adenomas (PA) in patients with phenocopy of MEN 1 (phMEN 1) and genetically confirmed MEN 1 (gMEN 1) compared with their sporadic forms.

MATERIALS AND METHODS: immunohistochemical assessment of the menin expression was carried out in PA of patients with gMEN 1, phMEN 1 and sporadic acromegaly (SA), surgically treated in 2008–2020. IHC was performed using antibodies to menin, PRL, GH, ACTH, FSH, TSH, Pit-1, T-box, ERA on previously prepared histological section.

RESULTS: The study included 35 samples of PA: gMEN 1 — 9 samples, phMEN 1 — 12 (somatotropinomas + PHPT); CA — 14  samples. The patients were comparable by gender, adenoma size, and drug intake. The gMEN  1 group differed from phMEN 1 and SA by age (p = 0.0005). In patients with gMEN 1, the expression of menin varied from no staining (5/9) to intense cytoplasm staining. Cytoplasmic expression of menin was mainly present (11/12) in the phMEN 1. In the SA group, there was no staining in 1 case; nuclear expression was detected in 6/14 cases. The phMEN  1 group showed significantly higher cytoplasmic expression of menin than the gMEN  1 group (p = 0.006). The gMEN 1 group also differed from the SA group (p = 0.012). There were no statistically significant differences between the phMEN 1 and SA groups (p = 0.049).

CONCLUSION: It was revealed that the menin expression, in general, is retained in phMEN 1 and SA groups, although with different localization in the cell structure (nucleus and / or cytoplasm). At the same time, the expression of menin varies greatly in patients with gMEN 1. According to the data obtained, it can be assumed that the pathogenesis of PA in phMEN 1 and SA may have similarities; however, there could be factors contributing to the appearance of several tumors of the endocrine glands in one person with phMEN 1. To understand this process, it is necessary to further study the genes associated with MEN 1, epigenetic factors, signaling pathways in which menin is involved.
Gene and cell therapy of adrenal pathology: achievements and prospects
Authors: Glazova O. V. , Vorontsova M. V. , Sakr N. , Shevkova L. V. , Onyanov N. A. , Kaziakhmedova S. A. , Volchkov P. Y.
Published: January 2022

Our current understanding of the molecular and cellular mechanisms in tissues and organs during normal and pathological conditions opens up substantial prospects for the development of novel approaches to treatment of various diseases. For instance, lifelong replacement therapy is no longer mandatory for the management of some monogenic hereditary diseases. Genome editing techniques that have emerged in the last decade are being actively investigated as tools for correcting mutations in affected organs. Furthermore, new protocols for obtaining various types of human and animal cells and cellular systems are evolving, increasingly reflecting the real structures in vivo. These methods, together with the accompanying gene and cell therapy, are being actively developed and several approaches are already undergoing clinical trials. Adrenal insufficiency caused by a variety of factors can potentially be the target of such therapeutic strategies. The adrenal gland is a highly organized organ, with multiple structural components interacting with each other via a complex network of endocrine and paracrine signals. This review summarizes the findings of studies in the field of structural organization and functioning of the adrenal gland at the molecular level, as well as the modern approaches to the treatment of adrenal pathologies.
Erratum: clinical and molecular characteristics of patients with 46,xy dsd due to nr5a1 gene mutations (Probl Endokrinol (Mosk). 2020 Sep 16;66(3):62-69. Russian. doi: 10.14341/probl12445)
Authors: Kalinchenko N. Yu. , Kolodkina A. A. , Raygorodskaya N. Yu. , Tiulpakov A. N.
Published: January 2022

n the article some corrections were needed. Abstract: “Heterozygous SF1 variants were found in 36 out of 310 (11.6%) of cases, among them 15 were not previously described”. has been corrected to read “Heterozygous SF1 variants were found in 36 out of 310 (11.6%) of cases, among them 22 were not previously described”. Results: “Heterozygous SF1 variants were found in 36 out of 310 (11.6%) of cases, among them 15 were not previously described”, has been corrected to read “Heterozygous SF1 variants were found in 36 out of 310 (11.6%) of cases, among them 22 were not previously described”. Among the newly identified variants in the NR1A1 gene, two lead to the premature stop codon -p. Y197X and p. Y25X, two lead to a shift in the reading frame-p. N385fs and p. L245fs, which does not allow us to doubt their pathogenicityAmong the previously undescribed variant changes, 5 missense mutations (p. C283Y, p. C283B, p.H24Q, p.M126K, p.E81K) and 1  synonymous substitution affecting the splicing site (E330E) were evaluated as pathogenic, and 5 others as probably pathogenic.

Has been corrected to read: Among the newly identified variants in the NR1A1 gene, two lead to the premature stop codon -p. Y197X and p. Y25X, two lead to a shift in the reading frame — p.N385SfsX10 and p.L245AfsX53, which does not allow us to doubt their pathogenicity Among the previously undescribed variants, 5 missense mutations (p.C283Y, p.С283F, p.H24Q, p.M126K, p.A82T) and 1 synonymous substitution affecting the splicing site (E330E) were predicted as pathogenic, and 5 others as probably pathogenic by calculating pathogenicity. The authors apologize for these errors.
Congratulations on your anniversary, dear Valentina Alexandrovna!
Authors: Editorial Article
Published: January 2022

December 1, 2021 — the anniversary of Valentina Aleksandrovna Peterkova, professor, academician of the Russian Academy of Sciences, scientific director of the Institute of Pediatric Endocrinology of the National Research Center of Endocrinology of the Ministry of Health of Russia, chief freelance specialist of the pediatric endocrinologist of the Ministry of Health of Russia, Honored Doctor of the Russian Federation.
SUMBANGSIH FREUD BAGI KEHIDUPAN SOSIAL-KEAGAMAAN: TELAAH ATAS KARYA TOTEM AND TABOO (1912-1913)
Authors: Sugiyono Paulus Bagus
Published: January 2022

One of Sigmund Freud's most famous works in the field of religion is Totem and Taboo (1912-1913). In this work, Freud uses psychoanalytic theory to dissect the genealogy of socio-religious phenomena in the form of totems and taboos from a philosophical-anthropological point of view, especially through his research on Aboriginal tribes in Australia. This article aims to examine Freud's contribution in the field of religion, and how it is contextualized in the socio-religious life of today's society. This study uses a qualitative approach by exploring various literatures that examine Freud's work on Totems and Taboos. The results of the study reveal that although this work tends to be problematic and particular in interpreting religion through the concepts of Totem and Taboo. However, there is a contribution from the series of arguments presented by Freud. This contribution is an invitation to purify one's intentions in carrying out religious rites, especially in today's modern society. Religious activity is no longer seen as a mechanistic ritual, but it has to be rooted from the deepest heart. Salah satu karya Sigmund Freud dalam bidang agama yang paling terkenal adalah Totem and Taboo (1912-1913). Dalam karyanya tersebut, Freud menggunakan teori psikoanalisis untuk membedah genealogi fenomena sosial keagamaan berupa totem dan taboo dari sudut pandang filosofis-antropologis, khususnya melalui penelitiannya tentang suku Aborigin di Australia. Artikel ini bertujuan untuk menelaah sumbangsih Freud dalam karya tersebut, dan bagaimana kontekstualisasinya dalam kehidupan sosial-keagamaan masyarakat saat ini. Penelitian ini menggunakan pendekatan kualitatif dengan menelusuri berbagai literatur yang mengkaji karya Freud tentang Totem dan Taboo. Hasil penelitian mengungkapkan bahwa meskipun karya ini cenderung problematis dan partikular dalam memaknai agama melalui konsep Totem dan Taboo, namun terdapat sumbangsih dari rangkaian argumentasi yang disampaikan oleh Freud tersebut. Sumbangsih tersebut adalah ajakan untuk memurnikan intensi diri dalam melaksanakan ritus-ritus beragama, khususnya dalam masyarakat modern saat ini. Aktivitas beragama bukan lagi menjadi ritual yang mekanistis, melainkan harus bersumber dari hati yang terdalam.
FUNDAMENTALS OF THE DESIGN OF FUNDAL MANDRELS FOR THE INSTALLATION OF THIN-WALLED WORKPIECES. PART 1
Authors: Blinov D. S. , Chunosov I. S.
Published: January 2022

There are a number of problems in mechanical engineering technology. One of them is related to the installation on the machine and the previous processing of thin-walled rings, which are widely used in mechanical engineering. Due to the low bending stiffness of thin-walled rings after processing there are a large magnitude of rigidity of the form (deviation from roundness). As production experience has shown, in the conditions of mass production, it is advisable to use fungal mandrels and adjustments to reduce shape errors. They allow for a small radial gap between the holes of the ring and the fungal cam to have extended contact rings with cams along the angular coordinate. However, there are no methods for calculating the parameters of contact interaction with cams, considering a number of factors, primarily the radial clearance. Hence, it is impossible to calculate more accurately the error of the form after processing. In this paper (it is supposed to be continued), based on methods for calculating flat rings of construction mechanics of machines, a method for determining the stress-strain state of a thin-walled state is proposed, considering the contact pressure. In this case, the semiangle of contact of the ring with the fungal cam and the shape of the contact pressure plot are determined. This allows you to calculate the stress state of the thin-walled ring and the shape error when processing more accurately in a fungal mandrel, as well as reasonably assign the dimensions of the mandrel parts. Due to the exceptionally large number of calculations in the calculations according to the proposed method, it can only be implemented using a computer program, which creates great difficulties in analyzing different source data. Therefore, it is planned to rework the completed developments into an engineering calculation method with graphs in dimensionless form.
CALCULATION OF PARAMETERS OF BRANCHED MECHANICAL SYSTEMS WITH HARMONIC VIBRATIONS. Continuation
Authors: Popov I. P
Published: January 2022

Parallel-series and series-parallel connections of mechanical power consumers are considered. According to the known parameters of systems and the disturbing harmonic effect, the velocities of the elements of mechanical systems and the forces applied to them are algebraically determined. For the considered branched mechanical schemes, the classical methods based on solving second-order differential equations become many times more complicated and require solving systems of equations that reduce to higher-order differential equations. The use of a symbolic (complex) description of mechanical processes and systems makes it possible to use instead simple and compact algebraic methods, the complexity of which is ten times less. Vector diagrams, not being a necessary component of the study of mechanical systems, are of significant methodological importance, since they show quantitative and phase relationships between the parameters of systems.
THE MAIN PARAMETERS OF THE STRENGTH CALCULATION OF NOVIKOV GEARING WITH STANDARD BASIC RACK PROFILE
Authors: Korotkin V. I. , Kolosova E. M.
Published: January 2022

The article shows the expediency of using Novikov gearing with standard basic rack profile and with hardened teeth for general purpose gearboxes, also with thermally improved teeth for special purpose gearboxes. It sets out the principled approach for solving the problem definition of basic parameters of the strength calculation of these gears, consisting of two stages: a) definitions of both basic bending, contact stresses and tooth rigidity, and phase taking into account the coefficients of influence of the gear face; b) modeling the process of real multipoint engagement with finding the criterial stress in dangerous sections of the teeth, which determine the load-bearing capacity and service life of the gearbox. Implementing this approach, we obtained generalizing results of solving a spatial problem of the stress-strain state of teeth at any position of the contact area along their length and the way of obtaining partial efforts at the contact area and criterion stresses is indicated. The dependencies, convenient for embedding in the developed computing programs, tables, approximating the power polynomials for determining the basic parameters of the contact were obtained. The completed studies are supposed to be issued in the form allows to offer the method of strength calculation of Novikov gearing with standard basic rack profile domestic machine-building enterprises, producing drives for general engineering and special purpose.
COMBINED EXTRUSION OF GLASSES WITH A CONICAL BOTTOM. MECHANICAL AND MATHEMATICAL ANALYSIS OF THREE OPTIONS FOR THE PROCESS
Authors: Vorontsov A. L. , Lebedeva D. A.
Published: January 2022

Using the general methods of A. L. Vorontsov, a mechanical and mathematical study of the first three variants of the process of combined extrusion of glasses with a conical bottom was carried out. All necessary design schemes are presented. Calculated formulas have been obtained that make it possible to determine the deformation forces and the magnitude of the plastic deformation areas for each possible variant of the plastic flow of the workpiece metal. These formulas also make it possible to determine which variant of deformation will occur in a particular case, and are necessary for the successful design of this operation.
RADIAL EXTRUSION OF A PIPE BILLET WITH INTERNAL LEDGE. METHODS FOR CALCULATING THE TECHNOLOGICAL PARAMETERS OF EXTRUSION OF PRODUCTS WITH THE SAME RADII OF THE UPPER AND LOWER PARTS
Authors: Vorontsov A. L. , Reshchikov E. O.
Published: January 2022

The scientifically grounded methods for calculating the main technological parameters of the internal radial extrusion of a pipe billet in order to obtain products with the same radii of the upper and lower parts. All formulas are given that are necessary to determine the strength of the process, the maximum stresses acting on various shaping elements of the stamp, to determine the accumulated deformations at any points of the resulting product, as well as to take into account the hardening of the extruded material.
The Stuff that Dreams are Made of: Os reflexos do noir
Authors: Francisco André
Published: January 2022

Recensão do livro Espelhos do Film Noir (2019), editado por Jeffrey Childs para a Documenta.
Cinema e Vídeo em Tempos de Pandemia: As mostras virtuais
Authors: De Sousa e Silva Alexsandro
Published: January 2022

O texto discute um festival de cinema e uma mostra de vídeo, exibidos em formato virtual. O primeiro é o Festival Cine Terreiro, sobre o sagrado afro-indígena. O segundo é a Mostra Joel Zito Araújo: uma década em vídeo, 1987-1997, panorama das primeiras produções deste cineasta, conhecido por obras antirracistas.
On the design of Remote Health Monitoring System
Authors: Abdulhamid Mohanad , Albert Muchisu
Published: January 2022

With improvement in technology and miniaturization of sensors, there have been attempts to utilize the new technology in various areas to improve the quality of human life. One main area of research that has seen adoption of the technology is the healthcare sector. The people in need of healthcare services find it very expensive, this is particularly true in developing countries. With improvement in technology previously expensive hospital equipment have been redesigned using current technology. The developments have seen a trend known as remote healthcare or previously known as Telemedicine. As a result, this paper is an attempt to solve a healthcare problem facing the society. The main objective of the paper is to design a remote healthcare system. It is comprised of three main parts. The first part being detection of a fall, second being detection of electrocardiogram commonly referred to as ECG or EKG( heartbeat detection) and the last part is providing the detected data for remote viewing. Remote viewing of the data enables a doctor or health specialist to monitor a patient’s health progress away from hospital premises.
Multiparameter Biosignal Analysis in Elderly Ischemic Stroke Patients
Authors: Zakariyah Muhammad , Sahroni Alvin , Marfianti Erlina
Published: January 2022

Biosignal can provide information about body conditions, including physiological conditions of ischemic stroke. The regulation of blood in the brain is regulated through the mechanism of Cerebral Autoregulation (CA). Some parameters that can be used to determine this mechanism are Blood Flow Velocity (BFV) and Blood Pressure (BP). Stroke is also related to nervous system activity, which is represented through the Heart Rate Variability (HRV). This study aims to determine the relationship between those biosignals and their effects on the physiology of ischemic stroke sufferers. The subjects were divided into two groups (20 strokes and 20 controls). BFV data is obtained in the Middle Cerebral Artery (MCA), BP is obtained through the arteries of the upper arms, and 3 leads electrocardiogram is placed in the chest. The results showed that there was a relationship between BP and BFV in the control group (p-value < 0.05; r = -0.574). This correlation was not found in the stroke group. The relationship between BP and HRV was only found in the stroke group, which was associated with high sympathetic activity and lower parasympathetic activity (p-values < 0.05 and r > 0.4). It was based on SDRR, RMSSD, CVRR, LF, and SD1 parameters. In the control group, there was no relationship between HRV and BP. The relationship between BFV and HRV in the control group was not found statistically. Still, in the stroke group, this relationship was found in the LF and LF/HF Ratio parameters (p-value < 0.05; r > 0.4). Based on this research, parameters on HRV that can be used to determine the characteristics of stroke patients in all positions are MeanRR, VLF, and LF
Design and Analysis of The Energy Storage and Return (ESAR) Foot Prosthesis Using Finite Element Method
Authors: Istiqomah Alfiana Fitri , Ismail Rifky , Fitriyana Deni Fajar , Sulistyo Sulistyo , Fardinansyah Akmal Putra , Safitri Murti Ayu Nur , Siregar Januar Parlaungan
Published: January 2022

ABSTRACT. Disability issue has increased in recent years due to the high number of accidents and vascular disease. Loss of limb function for people with amputations often results in an abnormal gait. Energy Storage And Return (ESAR) foot prostheses provide an alternative to help improve gait and minimize metabolic energy expenditure during the walking phase of amputees. This study used 3 designs with models from the Catia V5 Software. The finite element method analysis used Ansys Workbench 18.1 software to evaluate the three designs with a loading of 1.2 times the user's body weight with a maximum weight of 70 kg in normal walking activities. The simulated material is carbon fiber prepreg which has tensile strength, Young's modulus, Poisson ratio, and density of 513.72 MPa, 77.71 GPa, 0.14, and 1.37 g/cm3. The decision-making matrix method is used to determine the best foot prosthesis design according to predetermined criteria. The highest value in the decision-making matrix is 76 in Design 3. The chosen design (Design 3) after gait cycle analysis has a maximum von Mises stress value of 76.956 MPa and the safety factor value for each gait cycle heel strike loading model is 1.0762; foot flat 3.2509; toe-off 6.6263.
Polityka regionalna Unii Europejskiej: wnioski z doświadczeń Finlandii w latach 1995–1999
Authors: Kaczmarek Krzysztof
Published: January 2022

W artykule podjęto próbę analizy efektywności polityki regionalnej Unii Europejskiej i Finlandii wobec obszarów peryferyjnych w pierwszym dla tego państwa okresie programowania 1995–1999. Szczególna uwaga została poświęcona Laponii. Ze względu na niekorzystne warunki przyrodnicze region ten borykał się z wieloma problemami, spośród których pierwotnym wydaje się być depopulacja.

Polityka regionalna prowadzona wobec Laponii miała na celu zahamowanie tego procesu. Jednak błędy popełnione przy planowaniu skutkowały jej niepowodzeniem. Można zatem postawić hipotezę, że nie wysokość nakładów finansowych przeznaczonych na zwiększenie konkurencyjności regionu, ale znajomość jego specyfiki może przynieść pożądane efekty. Tymczasem, w kontekście polityki regionalnej wobec Laponii, okres 1995–1999 charakteryzował się niewłaściwym planowaniem opartym na zbyt powierzchownych analizach.
Konsensus i jego brak w Radzie Europejskiej – analiza przypadku reelekcji Donalda Tuska w 2017 r. z perspektywy zwrotu praktycznego
Authors: Ławniczak Kamil
Published: January 2022

Zarówno Rada, jak i Rada Europejska działają zgodnie z „kulturą konsensusu”, co oznacza, że nawet jeśli formalnie mogą decydować o niektórych sprawach większością kwalifikowaną, w praktyce rzadko to robią. Jest to szczególnie prawdziwe w przypadku Rady Europejskiej i dlatego dla wielu obserwatorów było zaskoczeniem, gdy 9 marca 2017 roku Donald Tusk został wybrany na drugą kadencję jako przewodniczący Rady Europejskiej, pomimo przeciwnego głosu jednego państwa członkowskiego (Polski). Wydarzenie to oznaczało, że Rada Europejska po raz pierwszy skorzystała z możliwości wyboru swojego przewodniczącego większością kwalifikowaną, a nie jednogłośnie.

W niniejszym artykule argumentuję, że stosowanie w takich sytuacjach formalnych przepisów pozwalających na głosowanie większością kwalifikowaną nie tylko nie podważa kultury konsensusu, ale wręcz jest niezbędne do jej utrzymania. Argument ten jest osadzony we wkładzie zwrotu praktycznego do badań politologicznych. Ten nurt umieszcza praktyki społeczne w centrum zainteresowania i podkreśla fakt, że mogą być one wykonywane mniej lub bardziej kompetentnie. Dlatego też, jeśli państwo członkowskie wykonuje „praktykę konsensusu” niepoprawnie, nie może oczekiwać, że normy, które tworzą kulturę konsensusu, pomogą mu narzucić swoje stanowisko innym państwom członkowskim. Ponieważ sposób funkcjonowania Rady Europejskiej jest trudno dostępny bezpośrednio, artykuł rozwija swoją argumentację, czerpiąc z dorobku badań nad procesem podejmowania decyzji w Radzie (w tym badań prowadzonych przez autora). Następnie przeprowadzona zostaje analiza dostępnych źródeł odnoszących się do wydarzeń z 2017 r., związanych z reelekcją Donalda Tuska.
„Specjaliści” od UE. O myśleniu potocznym jako granicy poznania wspólnoty europejskiej a sprawa polska (esej)
Authors: Kaźmierczak Marek
Published: January 2022

Główna hipoteza artykułu pt. ‘Specjaliści’ od UE. O myśleniu potocznym jako granicy poznania wspólnoty europejskiej a sprawa polska brzmi: rozumienie Unii Europejskiej jest kształtowane i wyznaczane przez zdrowy rozsądek (myślenie potoczne). Autor artykułu pokazuje, że kruchość UE jest zakorzeniona w doświadczeniu pornografii demokracji, w której zasady i prawa fundamentalne dla społeczeństwa demokratycznego są wykorzystywane przeciwko obywatelom (por. perspektywa polska czy węgierska). Dlatego zdrowy rozsądek jest traktowany jako granica myśli politycznej. Każdego można w tym kontekście potraktować jako specjalistę od ekonomii, ekologii, spraw międzynarodowych, historii itp. Zdrowy rozsądek urealnia emocje a nie fakty, dlatego można zaobserwować wiele przykładów dyskursów wykluczenia. Jest też inny ważny kontekst: status liberalizmu. Autor artykułu jest przekonany, że myśląc o liberalizmie powinniśmy mieć na uwadze „zwrot biologiczny”.
Unia Europejska wspólnotą wartości. Spojrzenie z perspektywy języka protestu oraz nowych środków wyrazu w Polsce
Authors: Molenda Krzysztof , Nowiak Wojciech
Published: January 2022

Artykuł odwołuje się w swojej analizie do postrzegania wartości Unii Europejskiej z perspektywy człowieka jako dobra najwyższego w kontekście zmian medialnych oraz protestów kobiet w Polsce pod koniec 2020 roku oraz społecznej aktywności demonstrującej przywiązanie Polaków do UE. Na początku trzeciej dekady XXI wieku istotnymi wartościami, podkreślanymi w przestrzeni publicznej są: dobro jednostek, wolność wypowiadania swoich poglądów, równość polityczna, społeczna oraz ekonomiczna dotycząca wszystkich, niezależnie od rasy, płci, orientacji seksualnej, kultury, religii, sympatii politycznych. Są one podstawą funkcjonowania wspólnoty ludzkiej w tym UE. Przestrzenią do obrony tych wartości, stały się nowe media w tym niezwykle istotne media społecznościowe.

Celem niniejszego artykułu jest praktyczna analiza, styku wartości o tradycyjnym, humanistycznym znaczeniu takich, jak kultura słowa oraz debaty publicznej z walką o wolność manifestowania swoich poglądów oraz obrony wartości przy użyciu nowych mediów. Co wbrew pozorom nie jest sprzeczne. Język protestu młodego pokolenia, nie jest poprawny, sięga do wulgaryzmów, ponieważ bardzo często jest to nie tylko zmiana pokoleniowa, lecz odpowiedź na język polityki i polityków. Polem do analizy jest spór polityczno-ideologiczny wywołany na polskiej scenie politycznej. Analiza na gruncie badań politologicznych oraz nauki o mediach, oparta została na badaniu źródeł zarówno literatury naukowej, jak i Internetu oraz mediów społecznościowych. Studium przypadku są wydarzenia związane z protestem kobiet w Polsce oraz innymi wystąpieniami przeciwko polityce rządu. Charakter mediów społecznościowych powoduje, iż nie funkcjonuje w nich cenzura, jakakolwiek kontrola form wyrazu oraz treści. Jest to praktyczna realizacja wolności i prawa do wyrażania swoich poglądów oraz protestu. Taka forma wolności prowadzi do wulgaryzacji życia publicznego. Niejednokrotnie wulgaryzacja, słowna, gesty, symbole i ich użycie mają swoje źródła w obserwacji życia politycznego. Zdaniem autorów, ta forma wyrażania myśli, w tym również służąca obronie podstawowych społecznych wartości wymaga przedefiniowania i zrozumienia kontekstów kulturowych.
Anna Pacześniak, Bartosz Rydliński (red.), Europejskie partie polityczne. Dyskurs programowy w Unii Europejskiej, Warszawa 2021, Wydawnictwo Sejmowe, ss. 302.
Authors: Kruk Aleksandra
Published: January 2022

Recenzja
Konzeptionierung, Implementierung und Simulation einer neuen Regelung zur Optimierung eines chemischen Prozesses
Authors: Bodenburg Sven , Urner Frank , Scheich André , Stöcker Christian
Published: January 2022

Der Beitrag behandelt die Entwicklung, parametrische Auslegung und Simulation einer neuen Basisregelung für einen chemischen Prozess, der zuvor teilweise manuell gefahren wurde. Die besonderen Herausforderungen bei der Lösung dieser Automatisierungsaufgabe sind eine variable Totzeit für den Zustrom eines Eduktes, eine diskrete Gasanalyse mit einer Abtastzeit von 40 Minuten und hohe Anforderungen an eine ruhige Fahrweise trotz teilweise unbekannter Störungen. Es wird an diesem Beispiel gezeigt, dass praktische Probleme dieser Art, trotz spezieller Randbedingungen, durch standardisierte Regelungsansätze, wie PI-Kaskadenregelung, Verhältnisregelungen und Störgrößenaufschaltungen gelöst werden können.
A modular framework for optimal scheduling of industrial processes
Authors: Schild Axel , Rose Alexander , Grotjahn Martin , Luck Bennet
Published: January 2022

This paper proposes an extended Petri net formalism as a suitable language for composing optimal scheduling problems of industrial production processes with real and binary decision variables. The proposed approach is modular and scalable, as the overall process dynamics and constraints can be collected by parsing of all atomic elements of the net graph. To conclude, we demonstrate the use of this framework for modeling the moulding sand preparation process of a real foundry plant.
Implicit multilinear modeling
Authors: Lichtenberg Gerwald , Pangalos Georg , Cateriano Yáñez Carlos , Luxa Aline , Jöres Niklas , Schnelle Leona , Kaufmann Christoph
Published: January 2022

The paper introduces a subclass of nonlinear differential-algebraic models of interest for applications. By restricting the nonlinearities to multilinear polynomials, it is possible to use modern tensor methods. This opens the door to new approximation and complexity reduction methods for large scale systems with relevant nonlinear behavior. The modeling procedures including composition, decomposition, normalization, and multilinearization steps are shown by an example of a local energy system with a nonlinear electrolyzer, a linear buck converter and a PI controller with saturation.
Control education in the software age
Authors: Richter Jan H.
Published: January 2022

According to a commonplace saying, software is eating the world. Is software also eating control engineering? Software is currently transforming many industries including but not limited to automotive aiming at automated mobility services, agriculture moving to Agriculture 4.0, and factory automation with Industry 4.0. Software is simultaneously a flexible and universal functions enabler, and a driver of engineering complexity. At times, it seems that control engineers and software engineers are not understanding each other well enough. This article discusses two key engineering domains adjacent to control, systems and software engineering, covering engineering practice, design data exchange, and education. Finally, it suggests an extension to academic control curricula help to make control graduates even better team players.
Effect of Vaccination to COVID-19 Disease Progression and Herd Immunity
Authors: Caga-anan Randy L. , Raza Michelle N. , Labrador Grace Shelda G. , Metillo Ephrime B. , Castillo Pierre del , Mammeri Youcef
Published: January 2022

A mathematical model of COVID-19 with a delay-term for the vaccinated compartment is developed. It has parameters accounting for vaccine-induced immunity delay, vaccine effectiveness, vaccination rate, and vaccine-induced immunity duration. The model parameters before vaccination are calibrated with the Philippines’ confirmed cases. Simulations show that vaccination has a significant effect in reducing future infections, with the vaccination rate being the dominant determining factor of the level of reduction. Moreover, depending on the vaccination rate and the vaccine-induced immunity duration, the system could reach a disease-free state but could not attain herd immunity. Simulations are also done to compare the effects of the various available vaccines. Results show that Pfizer-BioNTech has the most promising effect while Sinovac has the worst result relative to the others.
To evaluate the role of placental human papilloma virus (HPV) infection as a risk factor for spontaneous preterm birth: a prospective case control study
Authors: Hooda Reetu , Baghla Neeru , Malik Nisha , Kaushik Samander
Published: January 2022

Objectives

i) To compare the placental human papilloma virus (HPV) deoxynucleic acid (DNA) status of preterm deliveries with full term deliveries and to identify high risk (HR) genotypes (HPV 16 and 18); and ii) To compare the perinatal outcomes of HPV positive with HPV negative pregnant women.

Methods

A case control study was carried out on 100 antenatal women with singleton live pregnancies admitted in labor ward of a tertiary care teaching hospital from April 2017 to March 2018. The two study groups were i) spontaneous preterm deliveries between 24 and 36 + 6 weeks (n=50) and ii) full term deliveries ≥37 weeks (n=50). The placental tissue was analysed for HPV DNA and HR HPV genotypes were detected by type specific primers. A comparative analysis of perinatal outcomes between HPV positive and negative women was done.

Results

An overall placental tissue HPV prevalence of 12% (12/100) was observed in study cohort which was not significantly different between preterm and full term deliveries (16 vs. 8%, p=0.218). HPV 16 was significantly associated with preterm births (p=0.04). Both HPV affected and non-affected women were comparable in terms of mode of delivery and neonatal outcomes. However, a statistically significant association of preterm neonatal intensive care admissions with HR HPV 16 genotype was observed (p=0.04).

Conclusions

Spontaneous preterm births can be attributed to placental HPV infection, specifically HR HPV 16 genotype. This association identifies a potentially preventable cause of prematurity and its associated complications, in wake of availability of an effective vaccine.
Children’s exposure to polycyclic aromatic hydrocarbon (PAHs): a review on urinary 1-hydroxypyrene and associated health effects
Authors: Hisamuddin Nur Hazirah , Jalaludin Juliana
Published: January 2022

This article reviewed the published studies on the environmental exposure to polycyclic aromatic hydrocarbons (PAHs) among children and assessed the urinary 1-hydroxypyrene (1-OHP) level as a biomarker of exposure to PAHs. The current knowledge of the potential health effects of increased 1-OHP in children was reviewed. Additionally, the influence of genetic polymorphism on the urinary 1-OHP level was discussed in this review. The assembled data showed that children who are attending schools or living close to industrial and polluted urban areas might have greater exposure to higher concentrations of PAHs with a higher level of urinary 1-OHP when compared to those children living in rural areas. Urinary 1-OHP may be a reliable biomarker for determining the genotoxic effects, oxidative stress and inflammation caused by exposure to PAHs. Strong research evidence indicated that the total body burden of PAHs should be evaluated by biomonitoring of 1-OHP in line with other urinary PAHs metabolites (with 2–3 rings) to evaluate recent total exposure to PAHs. Overall, the study suggests implementing a mitigation plan to combat air pollution to provide a cleaner environment for children.
Parámetros de obtención de un aislado proteínico a partir de la semilla de anacahuita y evaluación de sus propiedades antioxidantes y antihipertensivas
Authors: Juárez-Goiz José Mayolo Simitrio , González-Cruz Leopoldo , Núñez-Camargo Diego , Teniente-Martínez Gerardo , R-Medina Humberto , Bernardino-Nicanor Aurea
Published: January 2022

La anacahuita es una especie subutilizada; ya que las semillas de su fruto contienen alta concentración de proteínas, las cuales al ser aisladas pueden generar péptidos que brindan propiedades nutracéuticas, por lo que es necesario analizar los aislados con base en sus características químicas y nutracéuticas. El objetivo del presente trabajo fue obtener un aislado proteínico a partir de las semillas de anacahuita, así como caracterizarlo con base en su puntoisoeléctrico, masa molecular, digestibilidad in vitro, actividad antioxidante y actividad antihipertensiva. Los resultadosindicaron un rendimiento y digestibilidad in vitro de 83.8% y 87%, respectivamente; el punto isoeléctrico se alcanzó a pH 4.0, con una actividad antihipertensiva de 64%; el IC50 para la actividad antioxidante se alcanzó con 79.6 mg de aislado; y el perfil electroforético mostró la desnaturalización de la proteína con la aparición de nuevas bandas. Las proteínas de la semilla de anacahuita muestran alto potencial para ser utilizadas como compuestos nutracéuticos o para desarrollar procesos de hidrólisis incrementando su potencial.