bluuebunny/crossref_metadata_2025 huggingface dataset:
Surgical Outcome of Combined MicroPulse Transscleral Laser Therapy with Phaco Emulsification in Patients with Cataract and Glaucoma
Authors: Al Habash Ahmed , Otaif Wael
Published: November 2022

Purpose:

To determine the effectiveness and safety of combined MicroPulse transscleral laser therapy (TLT) and phacoemulsification in patients with co-existing cataracts and glaucoma.

Methods:

A retrospective consecutive case series of 22 eyes of 19 patients with co-existing cataract and glaucoma. The patients underwent MicroPulse TLT, phacoemulsification, and intraocular lens implantation during the same setting. A comparison of baseline data with the data at 18 months follow-up was made to determine the variation in best-corrected visual acuity (BCVA), intraocular pressure (IOP), and changes in the number of anti-glaucoma drugs.

Results:

Twenty-two eyes of 19 patients (57.9% were female) underwent combined MicroPulse TLT and phacoemulsification. The mean age was 60.5±9.3 years (range: 39.0 to 76.0). Nine eyes (40.9%) had primary open-angle glaucoma, nine eyes (40.9%) had chronic angle-closure glaucoma, and four eyes (18.2%) had pseudoexfoliation glaucoma. The mean baseline IOP was 26.3±4.7, which was significantly reduced to 15.3±2.4 mmHg (43.9%±10.2%) at 18 months (p<0.001). The median number of glaucoma medications was 4 (2 to 5) at baseline and 2 (0 to 4) at 18 months (p=0.002). The mean BCVA was 0.84±0.31 LogMAR (Snellen: 20/138) at baseline and 0.28±0.23 LogMAR (Snellen:20/38) at 18 months (p<0.001). The mean follow-up period was 15.8±3.0 months (range 12 to 18).

Conclusions:

Combined MicroPulse TLT and phacoemulsification was a safe and effective procedure that achieved reduction in both IOP and glaucoma medications for up to 18 months, with no associated vision-threatening complications.
Corneal Curvature, Anterior Chamber Depth, Lens Thickness, And Vitreous Chamber Depth: Their Intercorrelations With Refractive Error In Saudi Adults
Authors: Alrasheed Saif H. , Aldakhil Sulaiman
Published: November 2022

Background:

Ocular biometrics, such as corneal curvature, axial length, anterior chamber depth, and lens thickness, play a significant role in the development of refractive error and are essential in many clinical and research applications.

Objective:

To determine means and ranges for corneal curvature, axial length, anterior chamber depth, lens thickness, vitreous chamber depth, and their intercorrelations with refractive error in Saudi adults.

Methods:

A total of 120 eyes of 60 hyperopic and 60 myopic subjects aged 19-26 years old were enrolled in this comparative cross-sectional study. Axial Length (AL), Anterior Chamber Depth (ACD), Lens Thickness (LT), and Vitreous Chamber Depth (VCD) were measured by the SONOMED ultrasound E-Z SCAN AB5500+, A-scan, with a contact technique. An ophthalmometer measured the refractive status objectively by auto-refraction and the corneal radius of curvature.

Results:

The findings showed that the myopic eyes had a deeper ACD(3.70±0.27mm) than hyperopic eyes (3.28±0.32mm), P=0.0001. However, the hyperopic eyes had a thicker LT (3.84±0.24mm) than the myopic eyes (3.81±0.19mm), P=0.640. The mean of the corneal radius of curvature for the myopic eyes was slightly more curved (7.87±0.23mm) than for the hyperopic eyes (7.95±0.27mm), P=0.602. The myopic eyes had a higher axial length/corneal radius AL/CR ratio (3.12±0.11) than hyperopic eyes (2.89±0.06), with P=0.0001. Myopic spherical equivalent (SPH) positively correlated with VCD and AL/CR ratio, P=0.0001. Vitreous chamber depth/Axial length ratio (VCD/AL) in the myopic eyes was higher (0.693±0.041) than in the hyperopic eyes (0.677±0.018), P=0.000. Hyperopic SPH was positively associated with the VCD/AL ratio, P=0.0001.

Conclusion:

Myopic eyes had a deeper VCD than hyperopic eyes; there was a strong positive correlation between VCD and myopic SPH. There was a strong positive correlation between the AL/CR ratio and myopic SPH and a VCD/AL ratio and the hyperopic SPH. Thus, the study suggests the possible utility of the AL/CR ratio while assessing the development of myopic refractive error and the VCD/AL ratio when evaluating hyperopic eyes and their associated complications.
Pathophysiological Links Between Diabetes and Cardiovascular Diseases: at the Biochemical and Molecular Levels
Authors: Towhidul Islam M.M. , Kabir Yearul
Published: November 2022

The cardiovascular system mainly involves blood circulation to transport
oxygen, nutrients and metabolic compounds throughout the body. The blood is also
used to transport different endocrine hormones (for example, insulin) from the pancreas
to various cells in response to blood glucose levels. Unfortunately, any imbalance in
glucose and insulin levels may help to develop diabetes mellitus (DM) and increase the
risk of developing cardiovascular diseases (CVD) complications such as
atherosclerosis, hypertension, and myocardial infarction. Obesity plays a crucial role in
developing atherosclerotic plaques and other cardiovascular diseases. It is also
responsible for the inappropriate secretion of endocrine factors, resulting in metabolic
impairment of insulin target tissues and eventually failure of insulin-producing β-cells.
It has been found that 65% of diabetic patients develop cardiovascular problems.
Therefore, to know the underlying etiological factors, it is essential to study the
molecular mechanisms behind cardiovascular complications from diabetes.
Understanding the mechanisms and biomarkers of heart disease in diabetes research
can bridge the knowledge gap between diabetes and cardiovascular diseases.
Shifting Pancreas Transplantation Rates and Demographics are the Culmination of Many Strategic Policy Changes
Authors: Rechnitzer Alma , Teo Richard , Brooks Abigail , Rocca Juan , Mudhi Nidal , Torabi Julia , Ajaimy Maria , Liriano-Ward1 Luz , Azzi Yorg , Pynadath Cindy , Loarte-Campos Pablo , Akalin Enver , Le Marie , Kinkhabwala Milan , Graham Jay
Published: November 2022

The 2014 Pancreas Allocation System established national qualifying criteria for simultaneous kidney pancreas (SPK) transplantation. The 2019 UNOS Pancreas Transplantation Committee Policy 11.3.B modified these guidelines to expand transplantation. Subsequent effects on recipient demographics have not been studied. We analyzed 81 SPK transplantations performed at our center from June 2014 to December 2020 to compare recipient demographics and outcomes before and after the 11.3.B policy change. National data were also investigated. Significant increases in age (38.9 v 46.4 years; p = 0.01) and c-peptide levels (1.7 v 4.9 ng/ml; p = 0.01) occurred following the removal of BMI and c-peptide requirements. No differences in BMI, outcomes, or complication rates were found. National and center trends showed increasing numbers of recipients with high c-peptide levels and decreasing numbers of recipients with undetectable c-peptide levels. Policy 11.3.B expanded transplantation access while maintaining suitable outcomes, reflecting its intended goals.
Implementation of a Knowledge Management System in Mental Health and Addictions: Mixed Methods Case Study
Authors: Chorney Jill , Johnson Emberly Debbie , Jeffrey Jennifer , Hundert Amos , Pakkanlilar Onur , Abidi Sabina , Bagnell Alexa , Brennan Maureen , Campbell Leslie Anne , Clark Sharon , Bradley Kristina , Ross Olivia
Published: November 2022

Background

Mental health and addictions (MHA) care is complex and individualized and requires coordination across providers and areas of care. Knowledge management is an essential facilitator and common challenge in MHA services.

Objective

This paper aimed to describe the development of a knowledge management system (KMS) and the associated processes in 1 MHA program. We also aimed to examine the uptake and use, satisfaction, and feedback on implementation among a group of pilot testers.

Methods

This project was conducted as a continuous quality-improvement initiative. Integrated stakeholder engagement was used to scope the content and design the information architecture to be implemented using a commercially available knowledge management platform. A group of 30 clinical and administrative staff were trained and tested with the KMS over a period of 10 weeks. Feedback was collected via surveys and focus groups. System analytics were used to characterize engagement. The content, design, and full-scale implementation planning of the KMS were refined based on the results.

Results

Satisfaction with accessing the content increased from baseline to after the pilot. Most testers indicated that they would recommend the KMS to a colleague, and satisfaction with KMS functionalities was high. A median of 7 testers was active each week, and testers were active for a median of 4 days over the course of the pilot. Focus group themes included the following: the KMS was a solution to problems for staff members, functionality of the KMS was important, quality content matters, training was helpful and could be improved, and KMS access was required to be easy and barrier free.

Conclusions

Knowledge management is an ongoing need in MHA services, and KMSs hold promise in addressing this need. Testers in 1 MHA program found a KMS that is easy to use and would recommend it to colleagues. Opportunities to improve implementation and increase uptake were identified. Future research is needed to understand the impact of KMSs on quality of care and organizational efficiency.
Detection of Mental Fatigue in the General Population: Feasibility Study of Keystroke Dynamics as a Real-world Biomarker
Authors: Acien Alejandro , Morales Aythami , Vera-Rodriguez Ruben , Fierrez Julian , Mondesire-Crump Ijah , Arroyo-Gallego Teresa
Published: November 2022

Background

Mental fatigue is a common and potentially debilitating state that can affect individuals’ health and quality of life. In some cases, its manifestation can precede or mask early signs of other serious mental or physiological conditions. Detecting and assessing mental fatigue can be challenging nowadays as it relies on self-evaluation and rating questionnaires, which are highly influenced by subjective bias. Introducing more objective, quantitative, and sensitive methods to characterize mental fatigue could be critical to improve its management and the understanding of its connection to other clinical conditions.

Objective

This paper aimed to study the feasibility of using keystroke biometrics for mental fatigue detection during natural typing. As typing involves multiple motor and cognitive processes that are affected by mental fatigue, our hypothesis was that the information captured in keystroke dynamics can offer an interesting mean to characterize users’ mental fatigue in a real-world setting.

Methods

We apply domain transformation techniques to adapt and transform TypeNet, a state-of-the-art deep neural network, originally intended for user authentication, to generate a network optimized for the fatigue detection task. All experiments were conducted using 3 keystroke databases that comprise different contexts and data collection protocols.

Results

Our preliminary results showed area under the curve performances ranging between 72.2% and 80% for fatigue versus rested sample classification, which is aligned with previously published models on daily alertness and circadian cycles. This demonstrates the potential of our proposed system to characterize mental fatigue fluctuations via natural typing patterns. Finally, we studied the performance of an active detection approach that leverages the continuous nature of keystroke biometric patterns for the assessment of users’ fatigue in real time.

Conclusions

Our results suggest that the psychomotor patterns that characterize mental fatigue manifest during natural typing, which can be quantified via automated analysis of users’ daily interaction with their device. These findings represent a step towards the development of a more objective, accessible, and transparent solution to monitor mental fatigue in a real-world environment.
Effects of Customized Digital Health Care Service on Metabolic Syndrome Status and Lifestyle Using a Health Care App: Clinical Trial
Authors: Bae ChulYoung , Kim Bo-Seon , Cho KyungHee , Kim Ji-Hyun , Kim In-Hee , Kim Jeong-Hoon
Published: November 2022

Background

Untact cultures have rapidly spread around the world as a result of the prolongation of the COVID-19 pandemic, leading to various types of research and technological developments in the fields of medicine and health care, where digital health care refers to health care services provided in a digital environment. Previous studies relating to digital health care demonstrated its effectiveness in managing chronic diseases such as hypertension and diabetes. While many studies have applied digital health care to various diseases, daily health care is needed for healthy individuals before they are diagnosed with a disease. Accordingly, research on individuals who have not been diagnosed with a disease is also necessary.

Objective

This study aimed to identify the effects of using a customized digital health care service (CDHCS) on risk factors for metabolic syndrome (MS) and lifestyle improvement.

Methods

The population consisted of 63 adults who underwent a health checkup at the National Health Insurance Service Ilsan (NHIS) Hospital in 2020. Measured variables include basic clinical indicators, MS-related variables, and lifestyle variables. All items were measured at NHIS Ilsan Hospital before the use of the CDHCS and 3 months thereafter. The CDHCS used in this study is a mobile app that analyzes the health condition of the user by identifying their risk factors and provides appropriate health care content. For comparison between before and after CDHCS use (pre-post comparison), paired t test was used for continuous variables, and a chi-square test was used for nominal variables.

Results

The study population included 30 (47.6%) male and 33 (52.4%) female participants, and the mean age was 47.61 (SD 13.93) years. The changes in clinical indicators before and after intervention results showed a decrease in weight, waist circumference, triglyceride, and high-density lipoprotein cholesterol and increases in systolic blood pressure and diastolic blood pressure. The distribution of the risk group increased from 32 (50.8%) to 34 (54%) and that of the MS group decreased from 18 (28.6%) to 16 (25.4%). The mean metabolic syndrome age–chronological age before the CDHCS was 2.20 years, which decreased to 1.72 years after CDHCS, showing a decrease of 0.48 years in the mean metabolic syndrome age–chronological age after the intervention. While all lifestyle variables, except alcohol consumption, showed a tendency toward improvement, the differences were not statistically significant.

Conclusions

Although there was no statistical significance in the variables under study, this pilot study will provide a foundation for more accurate verification of CDHCS in future research.
Experiental Learning Sebagai Upaya Penguatan Pendidikan Demokrasi dan Pancasila
Authors: Nugroho Hastanti Widy , Utami Rona , Nugraha Rizky Anandasigit
Published: November 2022

Penelitian ini fokus pada transformasi metode pembelajaran Pancasila. Ada dua pertanyaan yang hendak dijawab, yaitu: 1) metode apa yang selama ini digunakan guru dalam pembelajaran Pendidikan Pancasila? Apa kelebihan dan kekurangan metode tersebut?; 2) apa inovasi yang dapat ditawarkan kepada guru Pendidikan Pancasila untuk membuat mata pelajaran Pancasila menjadi menarik? Berdasarkan hasil focus group discussion yang penulis lakukan di 72 sekolah yang tersebar di tiga kota, yakni Maluku, Kupang, dan Batam, sebagian besar guru masih menggunakan metode teacher centered learning karena keterbatasan sarana dan prasarana sekolah, serta kendala kemampuan guru. Implikasinya, output pembelajaran yang menekankan demokrasi dan kebhinekaan dalam kehidupan tidak tercapai maksimal dan kesenjangan kualitas pendidikan antar wilayah pedesaan dan perkotaan akan semakin besar. Oleh karena itu, penelitian ini bertujuan untuk menawarkan konsep experiential learning yang digagas oleh John Dewey sebagai basis metode penguatan pendidikan demokrasi dan Pancasila sebagai sarana dan tujuan untuk menggali pengalaman murid. Peneliti menyimpulkan experiential learning dapat mengatasi kesenjangan kualitas pendidikan dengan mendorong siswa untuk menjadi subjek aktif, bertanggung jawab, dan mandiri dalam proses belajarnya. Sedangkan guru berperan sebagai fasilitator yang membimbing aktivitas siswa. Apabila tahapan experiential learning dijalankan secara tepat, transformasi ini akan mendorong pembelajaran Pancasila yang lebih demokratis dan demokratisasi sejak dini.
Psychosocial Implications of COVID-19 on Children in Nigeria
Authors: Adewole Abiodun , Ogedengbe Kayode Anthony , Oyinlola Oluwagbemiga , Olanike Oyebade
Published: November 2022

There has been a plethora of research since the emergence of COVID-19 around the world but several of these studies have not focused on the psychosocial implication of the novel Coronavirus on children in Nigeria. Though the psychosocial impact of the virus is huge, there is paucity of literature addressing the needs of the Nigerian children during the pandemic. The paper explored the psychosocial implications (health, poverty issues, safety needs and learning) of COVID-19 on children in Nigeria. The study recommends the expansion of social assistance for children of families in extreme poverty, and there is a need to adapt standard physical distancing protocols to reflect the characteristics of children in different settings. Also, the Government of Nigeria should prioritize child-centred services. Training parents and caregivers on how to talk to their children about the pandemic, managing their mental health and providing tools to help children’s learning will be crucial.
Social Background, Self-esteem and Entrepreneurial Intention among Young Graduates of Higher Education in Côte d’Ivoire. Case of Université Félix Houphouet-Boigny, Cocody
Authors: OTEME Christophe Apolos
Published: November 2022

In a social context where unemployment is a societal problem with the emergence of a new phenomenon: graduate unemployment, entrepreneurship represents the palliative option for decision-makers, actors and other specialists in socio-professional integration. The present study, which is part of such a dynamic, aims to understand the problems related to female entrepreneurship. It therefore seeks to investigate the role of psychosociological determinants such as social background and self-esteem in the entrepreneurial intention of female graduates of Université Félix Houphouet-Boigny. A sample of three hundred and thirty-three (333) female students selected by the quota method participated in this study by means of a questionnaire.The results obtained (Student’s t-test) show on the one hand that the social environment of origin does not have a significant effect on the entrepreneurial intention of students at the Université Félix Houphouet-Boigny. On the other hand, self-esteem had a significant effect on students’ entrepreneurial intention. In other words, the results confirm that students with high self-esteem have a stronger entrepreneurial intention than those with low self-esteem. This study thus offers a way of thinking about the approach to female entrepreneurship in our current social context, which is faced with an employment crisis among young graduates.
Analysis of Judicial Health Claims in the Municipality of CATALÃO/GO (2020-2022)
Authors: Cândido Mariana Coelho , Almeida Emerson Gervásio de
Published: November 2022

The purpose of this article is to analyze the judicialization of health in the Municipality of Catalão/GO in the 2020/2022 biennium. An original study was carried out, by a previously trained researcher and in double conference, with a qualitative approach, using bibliographic and documentary analysis from files in the public domain, available electronically on the websites of public agencies. Fifty-six processes were selected. It was found that the predominant actions refer to individual writs of mandamus filed by the Public Ministry, to requests from women aged between 38 and 57 years, with non-standardized medicines in the National List of Essential Medicines (RENAME) being the most requested object. The realization of rights generates social and financial costs. The taxes created to promote public policies are insufficient for the realization of rights, especially health, which collapsed during the pandemic triggered by Covid-19. Thus, the principle of reserve of the possible, imported from European law and modified when inserted in Brazilian doctrine, must be used with balance and guaranteeing minimum conditions of survival and human dignity, under penalty of offending the Federal Constitution.
Environmental Education and the training of the Pedagogist
Authors: Cruz Iandra Aparecida Da , Kataoka Adriana Massae , Zanlorenzi Maria Josélia , Liebel Samuel
Published: November 2022

This study aims to disseminate the results obtained during the research entitled Environmental Education and the formation of the pedagogue, the research sought to analyze the knowledge of the students of the pedagogy course of a higher education institution, on the environmental theme acquired in the course. This is a qualitative research, a total of 46 academics participated in our research. Data were collected through a questionnaire and a focus group. The research results even revealed that the academics, having had access to the foundations and methodologies of a critical Environmental Education, what predominates is the conservative and pragmatic aspect in their answers. This result can be attributed to the difficulties and influences faced by these academics throughout their training from initial training to even during the undergraduate course, such as a conservative basic education, or wide dissemination of pragmatic Environmental Education, through the means of Communication.
Application of Machine Learning in Drug Discovery and Development Lifecycle
Authors: Jain Geerisha
Published: November 2022

Machine learning and Artificial Intelligence have significantly advanced in recent years owing to their potential to considerably increase the quality of life while reducing human workload. The paper demonstrates how AI and ML are used in the drug development process to shorten and enhance the overall timeline. It contains pertinent information on a variety of Machine Learning approaches and algorithms that are used across the whole drug development process to speed up research, save expenses, and reduce risks related to clinical trials. A range of QSAR analysis, hit finding, and de novo drug design applications are used in the pharmaceutical industry to enhance decision-making. As technologies like high-throughput screening and computation analysis of databases used for lead and target identification and development create and integrate vast volumes of data, machine learning and deep learning have grown in importance. It has also been emphasized how these cognitive models and tools may be used in lead creation, optimization, and thorough virtual screening. In this paper, problem statements and the corresponding state-of-the-art models have been considered for target validation, prognostic biomarkers, and digital pathology. Machine Learning models play a vital role in the various operations related to clinical trials embracing protocol optimization, participant management, data analysis and storage, clinical trial data verification, and surveillance. Post-development drug monitoring and unique industrially prevalent ML applications of pharmacovigilance have also been discussed. As a result, the goal of this study is to investigate the machine learning and deep learning algorithms utilised across the drug development lifecycle as well as the supporting techniques that have the potential to be useful.
Evaluation der Klinischen Forschungsgruppen. Abschlussbericht von inspire research im Auftrag der Deutschen Forschungsgemeinschaft (DFG)
Authors:   inspire research Beratungsgesellschaft m.b.H., Geyer Anton
Published: November 2022

Die Deutsche Forschungsgemeinschaft (DFG) fördert seit dem Jahr 2001 Klinische Forschungsgruppen (KFO) an hochschulmedizinischen Einrichtungen (HME). Mit KFO sollen wissenschaftliche Arbeitsgruppen, die sich krankheits- oder patientenorientierter (translationaler) klinischer Forschung widmen, dauerhaft verankert und vernetzt werden. Die Zusammenarbeit in einer KFO soll zu Ergebnissen führen, die mit den Möglichkeiten der DFG-Einzelförderung nicht erreicht werden können. Die Evaluation liefert eine Bestandsaufnahme über den Programmverlauf und prüft, inwieweit es dem Instrument KFO gelingt die erwarteten Ziele zu erreichen.
Food Recognition Using Extreme Learning Machines
Authors: T K Sanjeev , Meleet Merin
Published: November 2022

Abstract: New pictures of current classes are always arriving in open-ended continuous learning, and new classes are constantly appearing. Due to the great generalization capacity which was before deep learning networks, transfer learning was utilized to identify the most effective network for feature extraction from food photos. During transfer learning, it leverages online data augmentation to make up for the paucity of datasets from other orientations. Experimental research has demonstrated that the model's capability to categorize food photos from various potential orientations has been greatly improved by online data augmentation. Second, this study effort decreases the dimensions of retrieved features by using the Relief F technique to rank features. The redundant characteristics make the model's computations more difficult. The best epoch is achieved by getting a training accuracy of 98 percent and a validation accuracy of 92 percent.
Design and Implement a Semi-Automatic Clutch System for Automobiles Using DCV and the Link Mechanism to Reduce Human Effort While Increasing Process Reliability and Accuracy
Authors: Hariharan S. , Manikandan P. , Srinivasan P. , Kannarasu V.
Published: November 2022

Abstract: The pure sense of automation is to reducing the human effort and increasing the reliability and accuracy of the process. The objective of the project is to design and implement a semi-automatic clutch system for automobiles, which provides a simplistic remedy for physically challenged. Applying clutch manually at every instant, while changing gear is comfortless. In synchronizing switch with clutch pedal differently-abled people realize more difficulty inCBA pedal system. During the rush hour of traffic, the driver should be able to shift the legs simultaneously to change the gears, but it is practically a hectic work for the driver to do so. Automationcan be achieved through computer, hydraulics, pneumatics, robotics, etc., of these sources’pneumatics form an attractive medium for low-cost automation. Automation plays an important role in automobile. Technical success of this project relies upon the work expected from the different sectionsof this project. The actuation of the clutch pedal depends upon the signal from the DCV and the link mechanism is used for engaging and disengaging the clutch. Hence this project can be used in either automatic mode or in the manual mode in which the link mechanism can be removed out when not necessary in the hill stations where to remain the vehicles in Half-clutch. The entire process is controlled by using the directional controlvalve in which the retraction speed of the systemis controlled by throttling valve or needlevalve
Exploratory Data Analysis and Forecasting the Output Power Generated by Solar Photovoltaic
Authors: Malik Amir Yousuf , Kaur Baljit , Mushtaq Zahid
Published: November 2022

Abstract: Due to solar PV panels' growing feasibility as a renewable energy source, PV panel installations have surged recently. Machine learning algorithms can now generate better predictions due to the increasing availability of data and computing capacity. For many stakeholders in the energy business, predicting solar PV energy output is crucial, therefore machine learning and time series models may be used to do this. In this study, time series models and several machine learning techniques are compared across five different sites in India. Since the energy time series are non-stationary, we find that applying time series models is a challenging process. On the other hand, putting machine learning methods into practice was simpler.
Leukemia Diagnosis Using Deep Learning
Authors: Patil Prof. P. S. , Kunwar Ujjwal , Gandalwad Manthan , Gurme Narsing , Shinge Akash
Published: November 2022

Abstract: Leukemia is a deadly malignancy and there are two main types: acute and persistent. Each type has two subtypes: lymphoid and myeloid. There are a total of four subtypes of leukemia. This study proposes a new approach to the disease of all leukemia subtypes from the concept of small blood cells using convolutional effects on living neural organ networks (CNNs) that require large preparative files.
A Deep Neural Network Approach on Spleen Cancer Detection using DenseNet-201
Authors: Nazir Nazish , Singh Ravinder Pal , Mehra Dr. Monika
Published: November 2022

Abstract: Spleen is the largest secondary lymphoid organ and play a crucial role in the regulation of innate and adaptive immune. Among all cancers, spleen cancer is one of the serious diseases which effects minor population across the globe but is potentially fatal, especially if diagnosed in a later stage of development with a 20% survival rate at 6 months. Given the intricacy of the problem, several computer-aided diagnostic methods have been proposed and developed to increase the survival rate Spleen Cancer is a malignancy of white blood cells involving tumour deposits in the spleen. Most splenic cancer do not start in the spleen, and those that do, are almost always lymphomas. Lymphoma is a type of blood cancer that develops in the lymphatic system. Although there are many systems available with the medical industry, but this research is proposed to improve the performance of existing system by employing deep learning feature of Artificial Intelligence (AI) using Convolution Neural Networks (CNN), where Convolution Neural Networks (CNN) has been implemented using DenseNet-201. This research accomplished the desired parameters with values to achieve 99.60% accuracy and 0.1240 % loss while training and testing the model. The research has been supported with the datasets from Kaggle, IEEE transactions on information technology in biomedicine and IEEE International Symposium on Biomedical Imaging. The data set contains three clinical types spleen cancer, such as CLL (chronic lymphocytic leukemia); FL (follicular lymphoma); MCL (mantle cell lymphoma).
Traditional Korean Medicine Treatment for Sequelae After Surgery in Prostate Cancer Patients: Two Case Report
Authors: Jang Kwon-jun , Yang Jung-min , Hwang Woo-seok , Lee Beom-joon
Published: November 2022

Objectives: The purpose of this study is to report two cases of prostate cancer patients whose side effects after surgery were treated with traditional Korean medicine.Methods: Two prostate cancer patients underwent robot-assisted laparoscopic prostatectomy, and both patients were treated with traditional Korean medicine. Subjective discomfort symptoms were evaluated using the Numerical Rating Scale. Adverse events were evaluated using the National Cancer Institute Common Terminology Criteria for Adverse Events, version 5.0. Daily life vitality was evaluated by the Eastern Cooperative Oncology Group.Results: After treatment with traditional Korean medicine, discomfort symptoms that occurred after surgery, such as frequent urination, nocturia, insomnia, and depression, all gradually improved, and Eastern Cooperative Oncology Group scores also improved from two points to one point. Additionally, there were no hematologic side effects from the traditional Korean medicine treatment.Conclusions: This case study suggests that traditional Korean medicine may contribute to the improvement of side effects caused by robot-assisted laparoscopic prostatectomy, quality of life, and immunity.
A Case Report of Recurrent L858R Mutation Non-Small-Cell Lung Cancer with Brain Metastases Treated with Erlotinib and Traditional Korean Medicine After Failure with Gefitinib
Authors: Yang Jung-min , Jang Kwon-jun , Hwang Woo-seok
Published: November 2022

Objectives: The purpose of this study is to report the case of a patient with recurrent L858R mutation non-small-cell lung cancer with brain metastases treated with erlotinib and traditional Korean medicine after gefitinib failure.Methods: The patient was treated with erlotinib beginning in November 2021, and gamma knife surgery was performed on November 8, 2021. The dose of erlotinib was 150 mg/day every four weeks. At the same time, the patient was treated with traditional Korean medicine. Tumor size and cerebral edema were measured using computed tomography and magnetic resonance imaging, respectively. Adverse events were evaluated using the National Cancer Institute Common Terminology Criteria for Adverse Events, version 5.0.Results: After treatment with erlotinib and traditional Korean medicine for six months, the extent of the growing nodule in the right upper lobe decreased during the first three months and remained stable for the following three months. Peritumoral edema showed an increase three months after gamma knife surgery, but partial improvement of cerebral edema was confirmed with additional traditional Korean medicine six months after gamma knife surgery. The symptoms of discomfort and physical activity gradually improved.Conclusions: This case study suggests that the combination of EGFR-TKI and traditional Korean medicine may contribute to a reduction in tumor size and cerebral edema while improving quality of life.
Atenção primária e capacitação profissional para aplicação das práticas integrativas e complementares: revisão integrativa
Authors: Carrer Claudiohana , Marchini Julia Gabriela Santi , Khalaf Daiana Kloh , Freire Márcia Helena de Souza
Published: November 2022

The objective of this study was to analyze the process of professional training and qualification for Integrative and Complementary Practices and to propose strategies for permanent health education, aiming at the continuity and integrality of care in Primary Health Care (PHC) and at home. This is an integrative review, carried out in the Virtual Health Library and in the PubMed, Scopus, SciELO, Web Of Science and CINAHL databases. The sample consisted of 13 studies. The results were grouped into four categories: professional training and qualification education on Integrative and Complementary Practices; the knowledge and advantages of training to offer Integrative and Complementary PracticesS; the most used Integrative and Complementary Practices; and, the predominant professional areas in the process of applying for Integrative and Complementary Practices. The state of the art on the process of training and application of Integrative and Complementary Practices in Primary Health Care can be known, by professionals graduated in the health area, filling knowledge gaps and providing suggestions for health permanent education strategies.
The pattern of mortality among children hospitalized in the children emergency ward of a single tertiary hospital in Nigeria
Authors: Onubogu Uchenna C. , West Boma A. , Azubogu Uju S.
Published: November 2022

Purpose: This study was performed to review the mortality pattern at the emergency ward (EW) of the Rivers State University Teaching Hospital, Port Harcourt, Nigeria.Methods: A retrospective review of mortality among children hospitalized in the EW was conducted from January 2015 through May 2017. Information on their age, sex, weight, diagnosis, and mortality was recorded. The data were expressed in frequencies, and logistic regressions were performed with mortality as the dependent variable.Results: The median age of the 1,020 children hospitalized in the EW was 1.0 year (interquartile range, 0.6-4.0) with death recorded in 60 children, a 5.9% mortality rate. Mortality was higher in the children younger than 2 years, boys, and those with infectious diseases. Of the 60 dead children, infectious diseases were the leading cause of mortality (53 [88.3%]) with sepsis (22 [36.7%]), gastroenteritis (10 [16.7%]), and meningitis (6 [10.0%]), accounting for the highest contributors to mortality. The highest case fatality rates were noted in tetanus (1/1 [100%]), human immunodeficiency virus (5/14 [35.7%]), and tuberculosis (2/7 [28.6%]). The logistic regression showed that age of 13-16 years (adjusted odds ratio, 4.59; 95% confidence interval, 1.80-11.20; compared with age < 2 years) and presence of infectious diseases (4.65; 1.80-12.10) significantly increased the risk of mortality. Conclusion: The mortality rate in our EW during the study period was 5.9%. Infectious diseases remained significant contributors to mortality in our practice. Greater efforts at prevention and control of the diseases are required to correct this negative trend.
Internationality of value chain activities and the export orientation of micro- and small family businesses in Western Austria
Authors: Situm Mario , Märk Stefan
Published: November 2022

Based on a sample of 461 micro- and small family businesses in Western Austria, this study aimed to analyze the degree of internationalization of individual activities in the value chain and their influence on the export probability of family firms. The results show that exporting and non-exporting micro- and small family businesses are internationalized in different value chain activities and can partly explain the export probability. The resource-based view (RBV) can only be used to a limited extent to explain the export activities of micro- and small family firms, and certain firm-specific and individual-decision-maker characteristics can significantly explain export probability. The findings suggest that a) micro- and small family firms take different paths of internationalization concerning their value chain and b) that the global value chain (GVC) approach should be integrated into theoretical concepts to obtain an improved explanatory model of the internationalization behavior of (family) businesses.
Evaluación formativa y transformativa. Una mirada desde las pruebas diagnósticas
Authors: Cardona Colorado Ana Lucía , Ramírez Rave Juan Manuel
Published: November 2022

El documento Parámetros de diseño y calificación de pruebas diagnósticas en competencias comunicativas Universidad Tecnológica de Pereira (2020-2) es un esfuerzo conjunto de varios docentes interesados en potenciar las habilidades para el pensamiento crítico y complejo. Por lo tanto, este escrito integra parte del proceso realizado dentro de la investigación llamada Evaluación formativa en procesos de lectura y escritura en los niveles de Primaria, Básica y Media, en algunas Instituciones Educativas de Risaralda, cuyo propósito se centraba en la reflexión sobre las didácticas ancladas a las nociones de evaluación y sus repercusiones en el aula de clase. A partir de este ejercicio investigativo se determinó la necesidad de tender puentes entre las habilidades desarrolladas por los estudiantes, en la educación básica, y el proceso de alfabetización académica en la educación superior. Necesidad frente a la cual es imperioso generar un diagnóstico de los estudiantes que abarque habilidades no contempladas dentro de los exámenes estandarizados tradicionales, sino que amplíe sus fronteras hacia otras maneras de comunicar y leer desde la música, la entonación, la imagen. Así pues, esta prueba pretende reunir en una misma propuesta procesos de evaluación formativa, evaluación diagnóstica y evaluación estandarizada que permitan trazar rutas didácticas de atención y asesoramiento a los estudiantes y docentes de los diversos programas académicos ofertados en la Universidad Tecnológica de Pereira, dando forma a gran parte de las estrategias realizadas por el Programa de Acompañamiento en Lectura y Escritura (PALE) de la Universidad.
Short-term kinetics associated with triose phosphate utilization stress during photosynthesis addressed with dynamic assimilation measurements
Authors: Sharkey Thomas , McClain Alan
Published: November 2022

Oscillations in CO assimilation rate and associated
fluorescence parameters have been observed alongside the triose
phosphate utilization (TPU) limitation of photosynthesis for nearly 50
years. However, the mechanics of these oscillations are poorly
understood. Here we utilize the recently developed Dynamic Assimilation
Techniques (DAT) for measuring the rate of CO
assimilation to increase our understanding of what physiological
condition is required to cause oscillations. We found that TPU limiting
conditions alone were insufficient, and that plants must enter TPU
limitation quickly to cause oscillations. We found that ramps of CO
caused oscillations proportional in strength to the
speed of the ramp, and that ramps induce oscillations with worse
outcomes than oscillations induced by step change of CO
concentration. An initial overshoot is caused due to a
temporary excess of available phosphate. During the overshoot, the plant
out-performs steady state TPU and ribulose 1,5-bisphosphate regeneration
limitations of photosynthesis but cannot exceed the rubisco limitation.
We performed additional optical measurements which support the role of
photosystem I reduction and oscillations in availability of NADP
and ATP in supporting oscillations.
Complete Form of Pachydermoperiostosis with Good Initial Response to Etoricoxib: A Case Report
Authors: Baniya Abinash , Bhattarai Ayam , Devkota Bibek , Khatiwada Saurav , Kafle Pramod , Phuyal Achyut , Shahi Manoj
Published: November 2022

Pachydermoperiostosis (PDP) is a rare genetic disorder with unclear
etiopathogenesis. We report a case of a 38-years-old male who presented
with classic features of PDP. Patient showed a good initial response to
Etoricoxib therapy but the safety and efficacy over long-term use are
yet to be determined in further studies.
Plant-based green-synthesized silver nanoparticles: Introducing a modern chemotherapeutic drug to treat the human lung carcinoma
Authors: Chen Jingsheng
Published: November 2022

In this study, Urtica dioica L extract as a stabilizing and reducing
agent was utilized to synthesize silver nanoparticles in the aqueous
medium. Various techniques containing UV-Vis. spectroscopy, FT-IR
spectroscopy, X-ray diffraction (XRD), scanning electron microscopy
(SEM), and Transmission electron microscopy (TEM) were used to
characterize the synthesized nanoparticles (AgNPs). On the other hand,
the MTT assay was run to evaluate anti lung cancer activity of AgNPs.
The uniform spherical morphology ranging from 26.22 to 65.18 nm was
detected in the SEM images for the biosynthesized nanoparticles. The
crystal size of AgNPs, according to the XRD analysis, was 48.11 nm. In
the cellular and molecular part of the recent study, the treated cells
with AgNPs@Urtica dioica L were assessed by MTT assay for 48 h about the
cytotoxicity and anti-human lung adenocarcinoma properties on normal
(HUVEC) and lung adenocarcinoma cell lines i.e. HLC-1, LC-2/ad, and
PC-14. The viability of malignant lung cell line reduced
dose-dependently in the presence of AgNPs@Urtica dioica L. The IC50 of
AgNPs@Urtica dioica L were 201, 108 and 143 µg/mL against HLC-1,
LC-2/ad, and PC-14 cell lines, respectively. In the antioxidant test,
the IC50 of AgNPs@Urtica dioica L and BHT against DPPH free radicals
were 125 and 60 µg/mL, respectively.
Research on temporal and spatial evolution and influencing factors of children’s programming attention analysis in China: Empirical analysis based on Baidu search index
Authors: Wang jiang'e , Li Junke , liu kai , Zhao Yulin
Published: November 2022

Children’s programming is widely aroused people’s concern, is a hotspot
of research on education, the children’s programming attention to
promoting the development of children’s programming education has
important significance. Using Baidu index, elastic coefficient, Gini
index and geographic concentration coefficient, this paper analyzes the
evolution of spatial and temporal distribution and influencing factors
of children’s programming attention in China, and establishes the model
through panel data model and carries out empirical analysis. The results
show that: the public’s attention to children’s programming continues to
rise, and is in a gentle stage of development at the present stage.
Spatial difference of children’s programming attention is opposite
bigger, the eastern region is the most popular children’s programming in
the three regions, followed by the, the western region, the internal
unbalance in east and west region, the central region in balance, and
the central region difference is small, to strengthen the development of
the western region to close the gap and balanced development. Regional
economic development level and education level have a significant impact
on children’s programming attention on the Internet, while educational
funds and education level have a significant impact on children’s
programming attention in eastern and central China. To improve the
development space of children’s programming, we can start from two
aspects: strengthening the creation of characteristic learning fields
for primary school children’s programming, and improving the wide
application of online learning.
Ustroj i djelovanje Dioničarskog društva mjesne željeznice Vinkovci-Županja-Savska obala u Budimpešti (1900. - 1906.)
Authors: Lajnert Siniša , Halapir Ivica
Published: November 2022

U radu autori s aspekta povijesti institucija obrađuju ustroj i djelovanje Dioničarskog društva mjesne željeznice Vinkovci-Županja-Savska obala u vremenskom periodu od godine 1900., kada je društvo osnovano, pa sve do godine 1906., kada je zajedno s Dioničarskim društvom vicinalne željeznice Osijek-Đakovo-Vrpolje udruženo u novo društvo pod nazivom Dioničarsko društvo sjedinjenih podravsko-posavskih vicinalnih željeznica. Sjedište društva, kao i kod većine vicinalnih željeznica, bilo je u Budimpešti. Željeznička pruga Vinkovci-Županja-Savska obala bila je u vlasništvu društva, ali u državnoj eksploataciji, odnosno upravi. Poslove dioničarskog društva obavljali su glavna skupština dioničara, ravnateljstvo i nadzorni odbor. Iako je društvo poslovalo s financijskim dobitkom, po eksploatacijskim i financijskim pokazateljima bilo je među slabijim vicinalnim željeznicama na prostoru Kraljevina Hrvatske i Slavonije. Nakon udruživanja, novoosnovano društvo predstavljalo je jednu od rentabilnijih privatnih vicinalnih željeznica na tome prostoru.
Posljednje godine i smrt Ferde Šišića (1938. - 1940.)
Authors: Globačnik Matko
Published: November 2022

U radu se detaljnije istražuje život i djelo istaknutoga hrvatskog povjesničara Ferde Šišića od početka 1938. do 1940. godine. Temeljni je istraživački problem koji se postavlja u radu rasvjetljavanje i karakterizacija međuodnosa Šišićeva profesionalnog rada kao povjesničara i njegova političkog djelovanja. U tome cilju se na temelju brojnih arhivskih izvora, periodike i dostupne literature rekonstruira cjelokupna Šišićeva djelatnost na polju historiografije, u kulturi i politici u tadašnjem povijesnom kontekstu, određenom institucionalnim strukturama Kraljevine Jugoslavije.
Impact of professional education on the development of the staff potential in a modern library
Authors: Fomenko Irina , Zamanova Irina , Ryadnova Svetlana
Published: November 2022

The article examines the need for professional education in the choice of the future profession, as well as the role of staff potential diagnostics in the work of a modern library, and the prospects and tasks in this sphere. The authors perform diagnostics of employees without special library education in municipal libraries of the Belgorod region, Russia. The study concludes that it is vital for library employees to get specialized education in librarianship in addition to that which they already have. In addition, libraries are advised to have a set of methods for diagnosing the potential of their staff with descriptions of these methods and options for their use.