bluuebunny/crossref_metadata_2025 huggingface dataset:
Awareness and use of nonoccupational HIV post-exposure prophylaxis and factors associated with awareness among MSM in Beijing, China
Authors: Sun Yanming , Li Guiying , Lu Hongyan
Published: August 2021

Background

Human immunodeficiency virus (HIV) sexual transmission among men who have sex with men (MSM) has increased markedly in Beijing, China, during the past decade. Nonoccupational HIV post-exposure prophylaxis (nPEP) is a highly efficacious biomedical prevention strategy that significantly reduces HIV-transmission risk. This study examined nPEP awareness among MSM and the factors influencing it.

Methods

Consecutive, cross-sectional MSM surveys were conducted from April to August of 2018 and 2019. Demographic data as well as that on behavior and awareness regarding nPEP was collected. Factors influencing nPEP awareness were assessed using univariate and multivariable logistic regression.

Results

There were 1,202 eligible responders recruited. Of the responders, 42.5% had nPEP awareness, and 59.9% expressed interest in receiving nPEP in the future, if required. Greater odds of nPEP awareness were associated with younger age, higher education level (adjusted odds ratio [aOR]: 4.011, 95% confidence interval [CI]: 2.834–5.678, P<0.001), higher income, use of the Internet to meet sexual partners (aOR: 2.016, 95% CI: 1.481–2.744, P<0.001), greater HIV-related knowledge (aOR: 3.817, 95% CI: 1.845–7.899, p<0.001), HIV testing (aOR: 2.584, 95% CI: 1.874–3.563, p<0.001), and sexually transmitted infections (aOR: 1.736, 95% CI: 1.174–2.569, P = 0.006). Lower odds of nPEP awareness were associated with greater stigma score (aOR: 0.804, 95% CI: 0.713–0.906, P<0.001).

Conclusions

The findings indicate suboptimal awareness and low utilization of nPEP in Beijing and highlight nPEP inequities among MSM with stigma. Strengthening the training of health service providers and peer educators in reducing stigma and disseminating nPEP knowledge is imperative.
Research on the spatial association network structure for innovation efficiency of China’s new energy vehicle industry and its influencing factors
Authors: Zhang Yining , Wu Zhong
Published: August 2021

It is of great significance to study the spatial network of the new energy vehicle (NEV) industry innovation efficiency and its factors to promote the rational allocation of innovative resources and the coordinated development of Chinese NEV industry. First, the Super Efficiency Data Envelope Analysis model is used to measure innovation efficiency in the NEV industry in Chinese provinces, and based on the results, the improved gravity model is applied to construct a spatial correlation network. Then, by applying social network analysis (SNA) to study NEV industry development node spatial correlations, we conclude that there is no overall hierarchical structure. The SNA are applied to examine spatial correlations with respect to NEV industry innovation efficiency in each province, and to analyze the role and position of each province in the spatial correlation network. Finally, the influencing factors of spatial correlation of the innovation efficiency of China’s NEV industry has been discussed. The result shows that the difference in spatial distance and R&D investment has a significant impact on the spatial correlation of the NEV industry.
Regional performance variation in external validation of four prediction models for severity of COVID-19 at hospital admission: An observational multi-centre cohort study
Authors: Wickstrøm Kristin E. , Vitelli Valeria , Carr Ewan , Holten Aleksander R. , Bendayan Rebecca , Reiner Andrew H. , Bean Daniel , Searle Tom , Shek Anthony , Kraljevic Zeljko , Teo James , Dobson Richard , Tonby Kristian , Köhn-Luque Alvaro , Amundsen Erik K.
Published: August 2021

Background

Prediction models should be externally validated to assess their performance before implementation. Several prediction models for coronavirus disease-19 (COVID-19) have been published. This observational cohort study aimed to validate published models of severity for hospitalized patients with COVID-19 using clinical and laboratory predictors.

Methods

Prediction models fitting relevant inclusion criteria were chosen for validation. The outcome was either mortality or a composite outcome of mortality and ICU admission (severe disease). 1295 patients admitted with symptoms of COVID-19 at Kings Cross Hospital (KCH) in London, United Kingdom, and 307 patients at Oslo University Hospital (OUH) in Oslo, Norway were included. The performance of the models was assessed in terms of discrimination and calibration.

Results

We identified two models for prediction of mortality (referred to as Xie and Zhang1) and two models for prediction of severe disease (Allenbach and Zhang2). The performance of the models was variable. For prediction of mortality Xie had good discrimination at OUH with an area under the receiver-operating characteristic (AUROC) 0.87 [95% confidence interval (CI) 0.79–0.95] and acceptable discrimination at KCH, AUROC 0.79 [0.76–0.82]. In prediction of severe disease, Allenbach had acceptable discrimination (OUH AUROC 0.81 [0.74–0.88] and KCH AUROC 0.72 [0.68–0.75]). The Zhang models had moderate to poor discrimination. Initial calibration was poor for all models but improved with recalibration.

Conclusions

The performance of the four prediction models was variable. The Xie model had the best discrimination for mortality, while the Allenbach model had acceptable results for prediction of severe disease.
Persisting symptoms three to eight months after non-hospitalized COVID-19, a prospective cohort study
Authors: Søraas Arne , Kalleberg Karl Trygve , Dahl John Arne , Søraas Camilla Lund , Myklebust Tor Åge , Axelsen Eyvind , Lind Andreas , Bævre-Jensen Roar , Jørgensen Silje Bakken , Istre Mette S. , Kjetland Eyrun F. , Ursin Giske
Published: August 2021

Long-COVID-19 is a proposed syndrome negatively affecting the health of COVID-19 patients. We present data on self-rated health three to eight months after laboratory confirmed COVID-19 disease compared to a control group of SARS-CoV-2 negative patients. We followed a cohort of 8786 non-hospitalized patients who were invited after SARS-CoV-2 testing between February 1 and April 15, 2020 (794 positive, 7229 negative). Participants answered online surveys at baseline and follow-up including questions on demographics, symptoms, risk factors for SARS-CoV-2, and self-rated health compared to one year ago. Determinants for a worsening of self-rated health as compared to one year ago among the SARS-CoV-2 positive group were analyzed using multivariate logistic regression and also compared to the population norm. The follow-up questionnaire was completed by 85% of the SARS-CoV-2 positive and 75% of the SARS-CoV-2 negative participants on average 132 days after the SARS-CoV-2 test. At follow-up, 36% of the SARS-CoV-2 positive participants rated their health “somewhat” or “much” worse than one year ago. In contrast, 18% of the SARS-CoV-2 negative participants reported a similar deterioration of health while the population norm is 12%. Sore throat and cough were more frequently reported by the control group at follow-up. Neither gender nor follow-up time was associated with the multivariate odds of worsening of self-reported health compared to one year ago. Age had an inverted-U formed association with a worsening of health while being fit and being a health professional were associated with lower multivariate odds. A significant proportion of non-hospitalized COVID-19 patients, regardless of age, have not returned to their usual health three to eight months after infection.
Prevalence of metabolic syndrome and associated factors among psychiatric patients at University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia
Authors: Woldekidan Nigist Alemayehu , Mohammed Ammas Siraj , Degu Amsalu , Tadiwos Yohannes
Published: August 2021

Background

Psychiatric patients are at increased risk of being overweight or obese, and subsequently develop metabolic syndrome. Nevertheless, data regarding associated factors for weight gain are limited and inconsistent.

Objective

The present study aimed to determine the risk of metabolic syndrome and its associated factors among psychiatric patients.

Method

A cross-sectional quantitative study was conducted among all psychiatric patients at the Psychiatric Unit of the University of Gondar Comprehensive Specialized Hospital from March 1- April 1, 2018. All eligible psychiatric patients were interviewed about their socio-demographic status,and clinical characteristics and useful parameters for the study were recorded from the medical records of the patients and by measuring waist to height ratio. Descriptive statistics were used to summarize baseline information.Binary logistic regression was used to determine the associated factors and P-value <0.05 and confidence interval (CI) of 95% were used as cut off points for determining statistical significance.

Result

From 300 patients included in the study, 168(56%) patients were females,and around 50.3% of the study participants had low literacy levels. As per waist to a height ratio scale, 58% (174) of the patients had a risk of metabolic syndrome. The Binary logistic regression analysis indicated that sex (p-<0.0001), occupation (p -0.032), marital status (p-0.006), and distance from the hospital (p<0.0001) were statistically significant determinants of metabolic syndrome risk in the psychiatric patient in our setting.

Conclusion

The majority of the psychiatric patients in the study setting had a risk of metabolic syndrome. Sex, marital status, employment status, and distance to the hospital were significantly associated with metabolic syndrome. Routine physical and laboratory investigations to detect metabolic syndrome are indispensable in psychiatric patients to prevent cardiovascular complications.
Racial and ethnic disparities in “stop-and-frisk” experience among young sexual minority men in New York City
Authors: Khan Maria R. , Kapadia Farzana , Geller Amanda , Mazumdar Medha , Scheidell Joy D. , Krause Kristen D. , Martino Richard J. , Cleland Charles M. , Dyer Typhanye V. , Ompad Danielle C. , Halkitis Perry N.
Published: August 2021

Although racial/ethnic disparities in police contact are well documented, less is known about other dimensions of inequity in policing. Sexual minority groups may face disproportionate police contact. We used data from the P18 Cohort Study (Version 2), a study conducted to measure determinants of inequity in STI/HIV risk among young sexual minority men (YSMM) in New York City, to measure across-time trends, racial/ethnic disparities, and correlates of self-reported stop-and-frisk experience over the cohort follow-up (2014–2019). Over the study period, 43% reported stop-and-frisk with higher levels reported among Black (47%) and Hispanic/Latinx (45%) than White (38%) participants. Stop-and-frisk levels declined over follow-up for each racial/ethnic group. The per capita rates among P18 participants calculated based on self-reported stop-and-frisk were much higher than rates calculated based on New York City Police Department official counts. We stratified respondents’ ZIP codes of residence into tertiles of per capita stop rates and observed pronounced disparities in Black versus White stop-and-frisk rates, particularly in neighborhoods with low or moderate levels of stop-and-frisk activity. YSMM facing the greatest economic vulnerability and mental disorder symptoms were most likely to report stop-and-frisk. Among White respondents levels of past year stop-and-frisk were markedly higher among those who reported past 30 day marijuana use (41%) versus those reporting no use (17%) while among Black and Hispanic/Latinx respondents stop-and-frisk levels were comparable among those reporting marijuana use (38%) versus those reporting no use (31%). These findings suggest inequity in policing is observed not only among racial/ethnic but also sexual minority groups and that racial/ethnic YSMM, who are at the intersection of multiple minority statuses, face disproportionate risk. Because the most socially vulnerable experience disproportionate stop-and-frisk risk, we need to reach YSMM with community resources to promote health and wellbeing as an alternative to targeting this group with stressful and stigmatizing police exposure.
Developmental fronto-parietal shift of brain activation during mental arithmetic across the lifespan: A registered report protocol
Authors: Artemenko Christina
Published: August 2021

Arithmetic processing is represented in a fronto-parietal network of the brain. However, activation within this network undergoes a shift from domain-general cognitive processing in the frontal cortex towards domain-specific magnitude processing in the parietal cortex. This is at least what is known about development from findings in children and young adults. In this registered report, we set out to replicate the fronto-parietal activation shift for arithmetic processing and explore for the first time how neural development of arithmetic continues during aging. This study focuses on the behavioral and neural correlates of arithmetic and arithmetic complexity across the lifespan, i.e., childhood, where arithmetic is first learned, young adulthood, when arithmetic skills are already established, and old age, when there is lifelong arithmetic experience. Therefore, brain activation during mental arithmetic will be measured in children, young adults, and the elderly using functional near-infrared spectroscopy (fNIRS). Arithmetic complexity will be manipulated by the carry and borrow operations in two-digit addition and subtraction. The findings of this study will inform educational practice, since the carry and borrow operations are considered as obstacles in math achievement, and serve as a basis for developing interventions in the elderly, since arithmetic skills are important for an independent daily life.
Genomic data from NSCLC tumors reveals correlation between SHP-2 activity and PD-L1 expression and suggests synergy in combining SHP-2 and PD-1/PD-L1 inhibitors
Authors: Toral Keller J. , Wuenschel Mark A. , Black Esther P.
Published: August 2021

The identification of novel therapies, new strategies for combination of therapies, and repurposing of drugs approved for other indications are all important for continued progress in the fight against lung cancers. Antibodies that target immune checkpoints can unmask an immunologically hot tumor from the immune system of a patient. However, despite accounts of significant tumor regression resulting from these medications, most patients do not respond. In this study, we sought to use protein expression and RNA sequencing data from The Cancer Genome Atlas and two smaller studies deposited onto the Gene Expression Omnibus (GEO) to advance our hypothesis that inhibition of SHP-2, a tyrosine phosphatase, will improve the activity of immune checkpoint inhibitors (ICI) that target PD-1 or PD-L1 in lung cancers. We first collected protein expression data from The Cancer Proteome Atlas (TCPA) to study the association of SHP-2 and PD-L1 expression in lung adenocarcinomas. RNA sequencing data was collected from the same subjects through the NCI Genetic Data Commons and evaluated for expression of the PTPN11 (SHP-2) and CD274 (PD-L1) genes. We then analyzed RNA sequencing data from a series of melanoma patients who were either treatment naïve or resistant to ICI therapy. PTPN11 and CD274 expression was compared between groups. Finally, we analyzed gene expression and drug response data collected from 21 non-small cell lung cancer (NSCLC) patients for PTPN11 and CD274 expression. From the three studies, we hypothesize that the activity of SHP-2, rather than the expression, likely controls the expression of PD-L1 as only a weak relationship between PTPN11 and CD274 expression in either lung adenocarcinomas or melanomas was observed. Lastly, the expression of CD274, not PTPN11, correlates with response to ICI in NSCLC.
The impact of chronic comorbidities at the time of breast cancer diagnosis on quality of life, and emotional health following treatment in Canada
Authors: Arneja Jasleen , Brooks Jennifer D.
Published: August 2021

Introduction

Advances in breast cancer screening and treatment have led to an increasing number of breast cancer survivors. The objective of this study was to determine the impact of comorbidities on self-reported quality of life (QOL) and emotional health following a breast cancer diagnosis and treatment.

Methods

Women with a personal history of breast cancer (N = 3,372) were identified from the cross-sectional Canadian Partnership Against Cancer (CPAC) Experiences of Cancer Patients in Transitions Survey. Multinomial (nominal) logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for the relationship between burden of comorbidities and overall QOL and emotional health (very poor/poor, fair, good, very good).

Results

Of the 3,372 participants, 57% reported at least one chronic condition at the time of breast cancer diagnosis. As the number of chronic conditions at diagnosis increased, the odds of reporting worse quality of life and emotional health following treatment also increased. Specifically, compared to women reporting very good QOL, for each additional chronic condition, women reported significantly higher odds of reporting good (OR = 1.22, 95% CI: 1.12, 1.32), fair (OR = 1.76, 95% CI: 1.58, 1.96), or poor/very poor (OR = 2.31, 95% CI: 1.86, 2.88) QOL. Similarly, for each additional comorbidity, women reported significantly higher odds of reporting good (OR = 1.17, 95% CI: 1.07, 1.28), fair (OR = 1.63, 95% CI: 1.46, 1.82), or poor/very poor (OR = 2.17, 95% CI: 1.81, 2.60) emotional health, relative to very good emotional health.

Conclusion

Breast cancer survivors coping with a high comorbidity burden experience worse overall QOL and emotional health following treatment. This highlights the importance of integrating information on comorbidities into survivorship care to improve the experience and overall outcomes of patients with complex needs.
Barriers to timely disclosure of HIV serostatus: A qualitative study at care and treatment centers in Dar es Salaam, Tanzania
Authors: Ismail Neelam , Matillya Nancy , Ratansi Riaz , Mbekenga Columba
Published: August 2021

Introduction

Disclosure of Human Immunodeficiency Virus (HIV) status is important to prevent the spread of HIV and maintain the health of people living with HIV, their spouses, and the community. Despite the benefits of disclosure, many people living with HIV delay disclosing their status to those close to them thereby increasing the risk for disease transmission. This study aimed to determine the barriers to timely disclosure of HIV serostatus for people living with HIV in Dar es Salaam, Tanzania, and identify what motivated disclosure.

Methods

A qualitative descriptive study using in-depth individual interviews was conducted with10 participants attending HIV care and treatment centers in Dar es Salaam. The participants were people living with HIV who had delayed disclosing their serostatus for more than one month after diagnosis. Data was analyzed using qualitative content analysis.

Results

Three categories emerged from the analysis: Barriers hindering timely disclosure, motivation for disclosure of serostatus, and consequences of delayed disclosure. Barriers to timely disclosure included denial of one’s status, the fear of stigmatization, fear of being separated or divorced, the need to protect loved ones, and lack of adequate knowledge about the disease. Reasons that motivated disclosure included gaining social support, preventing disease transmission and wanting to be at peace.

Conclusion

Timely disclosure is hindered by stigma because HIV is negatively perceived by the public. People living with HIV prefer not to disclose to avoid the negative consequences of disclosure, especially because of fear of being discriminated against and losing their social status, which plays a major role in social status in Tanzania.

Trust and adequate counseling from health care workers helps prompt disclosure.
Peripheral shift in the viable chondrocyte population of the medial femoral condyle after anterior cruciate ligament injury in the porcine knee
Authors: Costa Meggin Q. , Murray Martha M. , Sieker Jakob T. , Karamchedu Naga Padmini , Proffen Benedikt L. , Fleming Braden C.
Published: August 2021

Anterior cruciate ligament injuries result in posttraumatic osteoarthritis in the medial compartment of the knee, even after surgical treatment. How the chondrocyte distribution within the articular cartilage changes early in this process is currently unknown. The study objective was to investigate the chondrocyte distribution within the medial femoral condyle after an anterior cruciate ligament transection in a preclinical model. Forty-two adolescent Yucatan minipigs were allocated to receive unilateral anterior cruciate ligament surgery (n = 36) or no surgery (n = 6). Central coronal sections of the medial femoral condyle were obtained at 1- and 4 weeks after surgery, and the chondrocyte distribution was measured via whole slide imaging and a cell counting batch processing tool utilized in ImageJ. Ki-67 immunohistochemistry was performed to identify proliferating cells. Empty lacunae, karyolysis, karyorrhexis, and pyknosis were used to identify areas of irreversible cell injury. The mean area of irreversible cell injury was 0% in the intact controls, 13.4% (95% confidence interval: 6.4, 20.3) at 1-week post-injury and 19.3% (9.7, 28.9) at 4 weeks post-injury (p < .015). These areas occurred closest to the femoral intra-articular notch. The remaining areas containing viable chondrocytes had Ki-67-positive cells (p < .02) and increased cell density in the middle (p < .03) and deep zones (p = .001). For the entire section, the total chondrocyte number did not change significantly post-operatively; however, the density of cells in the peripheral regions of the medial femoral condyle increased significantly at 1- and 4 weeks post-injury relative to the intact control groups (p = .032 and .004, respectively). These data demonstrate a peripheral shift in the viable chondrocyte population of the medial femoral condyle after anterior cruciate ligament injury and further suggest that chondrocytes with the capacity to proliferate are not confined to one particular cartilage layer.
Association of minimal residual disease with clinical outcomes in Philadelphia chromosome positive acute lymphoblastic leukemia in the tyrosine kinase inhibitor era: A systemic literature review and meta-analysis
Authors: Zhang Wanhua , Jang Erguai
Published: August 2021

Minimal residual disease (MRD) appeared to be a potent prognostic indicator in patients with Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL), with potential value in informing individualized treatment decisions. Hence, we performed herein a systemic literature review and meta-analysis to comprehensively address the prognostic value of MRD in Ph+ ALL. Systematic literature review was conducted in PubMed, Embase, and Cochrane databases with the data access date up to September 23, 2020. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated with fixed-effects or random-effects models. Furthermore, subgroup analyses were performed to assess the robustness of the associations. 27 studies with a total number of 3289 patients were eligible for this meta-analysis. Combined HRs suggested that MRD positivity was associated with inferior event-free survival (EFS) (HR = 2.00, 95% CI 1.77–2.26) and overall survival (OS) (HR = 2.34, 95% CI 1.86–2.95). The associations remained statistically significant in subgroup analyses including age group, MRD timing, disease status at MRD, MRD cutoff level, et al. Our findings suggested MRD as a potent clinical tool for assessing the prognosis of Ph+ ALL. Further studies using MRD-based risk stratification might help optimize individualized treatment strategies for Ph+ ALL patients.
Coverage of the national surveillance system for human Salmonella infections, Belgium, 2016-2020
Authors: Van Goethem Nina , Van Den Bossche An , Ceyssens Pieter-Jan , Lajot Adrien , Coucke Wim , Vernelen Kris , Roosens Nancy H. C. , De Keersmaecker Sigrid C. J. , Van Cauteren Dieter , Mattheus Wesley
Published: August 2021

Introduction

The surveillance of human salmonellosis in Belgium is dependent on the referral of human Salmonella isolates to the National Reference Center (NRC). Knowledge of current diagnostic practices and the coverage of the national Salmonella surveillance system are important to correctly interpret surveillance data and trends over time, to estimate the true burden of salmonellosis in Belgium, and to evaluate the appropriateness of implementing whole-genome sequencing (WGS) at this central level.

Methods

The coverage of the NRC was defined as the proportion of all diagnosed human Salmonella cases in Belgium reported to the NRC and was assessed for 2019 via a survey among all licensed Belgian medical laboratories in 2019, and for 2016–2020 via a capture-recapture study using the Sentinel Network of Laboratories (SNL) as the external source. In addition, the survey was used to assess the impact of the implementation of culture-independent diagnostic tests (CIDTs) at the level of peripheral laboratory sites, as a potential threat to national public health surveillance programs.

Results

The coverage of the NRC surveillance system was estimated to be 83% and 85%, based on the results of the survey and on the two-source capture-recapture study, respectively. Further, the results of the survey indicated a limited use of CIDTs by peripheral laboratories in 2019.

Conclusion

Given the high coverage and the limited impact of CIDTs on the referral of isolates, we may conclude that the NRC can confidently monitor the epidemiological situation and identify outbreaks throughout the country. These findings may guide the decision to implement WGS at the level of the NRC and may improve estimates of the true burden of salmonellosis in Belgium.
Coronavirus disease 2019 and its potential animal reservoirs: A review
Authors: Islam Md. Sirazul , Hasib F. M. Yasir , Nath Chandan , Ara Jahan , Nu Mong Sing , Fazal Md. Abul , Chowdhury Sharmin
Published: August 2021

In the 21st century, the world has been plagued by coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a virus of the family Coronaviridae epidemiologically suspected to be linked to a wet market in Wuhan, China. The involvement of wildlife and wet markets with the previous outbreaks simultaneously has been brought into sharp focus. Although scientists are yet to ascertain the host range and zoonotic potential of SARS-CoV-2 rigorously, information about its two ancestors, SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV), is a footprint for research on COVID-19. A 96% genetic similarity with bat coronaviruses and SARS-CoV-2 indicates that the bat might be a potential reservoir of SARS-CoV-2 just like SARS-CoV and MERS-CoV, where civets and dromedary camels are considered the potential intermediate host, respectively. Perceiving the genetic similarity between pangolin coronavirus and SARS-CoV-2, many scientists also have given the scheme that the pangolin might be the intermediate host. The involvement of SARS-CoV-2 with other animals, such as mink, snake, and turtle has also been highlighted in different research articles based on the interaction between the key amino acids of S protein in the receptor-binding domain and angiotensin-converting enzyme II (ACE2). This study highlights the potential animal reservoirs of SARS-CoV-2 and the role of wildlife in the COVID-19 pandemic. Although different causes, such as recurring viral genome recombination, wide genetic assortment, and irksome food habits, have been blamed for this emergence, basic research studies and literature reviews indicate an enormous consortium between humans and animals for the COVID-19 pandemic.
Adherence to Kinect Adventure Games in Individuals with Parkinson’s Disease – An Experimental Study from Mysore, India
Authors: Vignesh Thillai , Mahadevan Renukadevi , Harish Sandeep Padantaya
Published: August 2021

BACKGROUND Individuals with Parkinson’s disease (PD) experience reduced balance ability and are prone to fall. As the disease advances with age, the traditional forms of physiotherapy are prone to fail in long-term exercise intervention as patients lose interest in performing the exercises. The use of virtual reality game technology consists of tasks in virtual environments that combine physical and cognitive demands in a fun and motivating manner which leads to adherence in a long-term exercise intervention. The objectives of the study were to know the adherence of Kinect adventure games in individuals with PD by attendance percentage of prescribed sessions and analyse the impact of balance after the games in them. METHODS An experimental study with pre-post design in which 11 individuals were selected, with a mean age of 67.8 years. Home-based balance exercises were given three days a week up to 6 weeks (18 sessions). Kinect adventure games were implemented for another six weeks. Adherence was measured by attendance percentage in terms of the frequency of sessions completed. The secondary outcome measure was to assess balance. Participants were evaluated before intervention and post-intervention using BESTest. Descriptive statistics were used to compare the BESTest scores of pre and post-intervention. RESULTS The adherence percentage of Kinect adventure game therapy was 38 %. The adherence percentage of home-based balance exercises was only 9 %. The best scores improved in home-based balance exercise compared to Kinect adventure game therapy. CONCLUSIONS The participants with Parkinson’s disease did not adhere to Kinect adventure game therapy. For the attended sessions the balance improved for home-based balance exercise compared to Kinect game therapy. KEY WORDS Exercise Barrier, Adherence, Balance Training, Virtual Reality, Video Games
Wernicke’s Encephalopathy with Normal Neuroimaging - Suspect and Treat - A Case Report
Authors: Wadekar Abhijit , Hepat Sanyukta , Giri Anamika , Acharya Sourya
Published: August 2021

Wernicke’s encephalopathy (WE) is an unrecognized nutritional deficiency which often goes unnoticed. WE is clinically often composed of a triad including nystagmus, ophthalmoplegia and altered mental status. Although this triad practically is present only in a handful of cases1 it is also described as an acute neuropsychiatric presentation of thiamine deficiency. Early diagnosis and prompt treatment are of utmost importance here as it can prevent chronic brain damage which is often the end effect of thiamine deficiency. Wernicke’s encephalopathy is most commonly found in patients with chronic alcoholism, less frequent in non-alcoholic patients. In non-alcoholic patients, Wernicke’s encephalopathy might develop due to erosion of upper portion of gastrointestinal tract or secondary to intractable vomiting, inadequate dietary intake or malabsorption. Other causes include malignancies (gastric cancer, leukaemia, lymphoma), hyperemesis, anorexia, thyroid conditions.1,2 Wernicke’s encephalopathy is caused due to thiamine (B1) deficiency. B1 is a water-soluble vitamin which acts as a co-factor for carbohydrate metabolism. It is also important for neuronal cell function.2 This vitamin can’t be synthesised in the human body and thus dietary intake play a very important role. Symptoms of thiamine deficiency Include - Nystagmus, ataxia, encephalopathy, mental confusion. Early onset includes symptoms like: - headache, irritability, fatigue and abdominal discomfort. Prophylactic thiamine supplementation forms a major treatment for patients at risk for developing refeeding syndrome (RFS). RFS is an underdiagnosed condition which is characterised by potential shift in the fluid and electrolytes.
Az árinformációk keresése, feldolgozása és felhasználása a vásárlások során: A szakértelem és az érdekeltség szerepe
Authors: Kenesei Zsófia
Published: August 2021

A cikk az információfeldolgozás modelljét alkalmazza az árinformációkra. Az árak speciális jellemzői eltérő sémákat eredményeznek, mint a termék más - márka, csomagolás stb. - típusú információi. Empirikusan tesztelt kutatási modelljébe a szerző bevont két, a fogyasztói magatartást erősen befolyásoló változót, a szakértelmet és az érdekeltséget.
Vitamin D imbalance effects on dentoalveolar system: a review
Authors: Diachkova E. Y. , Trifonova D. O. , Ibadulaeva M. O. , Runova G. E. , Fadeyev V. V. , Tarasenko S. V.
Published: August 2021

Vitamin D is a fat-soluble secosteroid that plays an important role in the human body. There are two main native forms – vitamin D3 (cholecalciferol) and vitamin D2 (ergocalciferol). The regulation of calcium-phosphate metabolism and ensuring adequate bone remodeling are the most studied function of vitamin D. In recent years, researchers have found out the «extra-bone» effects of vitamin D and it allows us to be convinced of the great role of this compound. The participation of active forms of vitamin D in the processes of immunomodulation, anti-inflammatory, antimicrobial, antiproliferative effects and stimulation of cell differentiation are reflected in diseases of the maxillofacial region.

In this article, we examined the main functions of vitamin D in the human body, the mechanisms of its action and influence on the occurrence and course of oral diseases. The discovery of the relationship between vitamin D deficiency and the processes of osseointegration, bone remodeling, the severity of chronic recurrent aphthous stomatitis, squamous cell carcinoma and periodontitis allow us to conclude that it is advisable to diagnose vitamin D deficiency in appropriate time and correction its serum level in dental patients.
Presupuestos deontológicos del juzgador para una desmitificación de la justicia.
Authors: De los Santos Olivo Isidro
Published: August 2021

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Street name changes as language and identity inscription in the cityscape
Authors: Tan Peter K. W. , Purschke Christoph
Published: August 2021

This article examines the role of language selection in constructing the cityscape of highly multilingual, postcolonial places like Malaysia and Namibia. The relationship between language policy, the construction of a national identity as well as linguistic inscriptions in the cityscape can be seen as part of language planning in relation to what gets represented, by whom, and for what purpose. We focus on street names as a typical target of language policy. In postcolonial societies, these renegotiations of the cityscape can be analysed against the backdrop of different processes, such as the erasure of names commemorating the colonial past, the inscription of important figures of the newly established nations, or the curation of the language regime with respect to the presence and symbolical function of languages. Using contrastive data and methodology, we analyse the renegotiation of postcolonial cityscapes in Kuala Lumpur (historical city centre, map data, large time span) and Windhoek (entire cityscape, newspaper reports, short time span). Our analysis establishes a notion of how the cityscape as a complex sociosymbolic text is being constantly rewritten by its actors. We find different motives attached to such processes of cultural representation, including national identity building and ideological consolidation of the cityscape.
Social networks and eating disorders during the Covid-19 pandemic
Authors: Vaccaro Concetta M. , Guarino Giulia , Conte Dario , Ferrara Emanuela , Ragione Laura Dalla , Bracale Renata
Published: August 2021

Objective

The purpose of this study is to assess the increase both in the use of the Internet and social media and in Google searches regarding eating disorders (ED) in Italy during the Covid-19 pandemic. Our aim is also to verify the possible impact of such an increase on ED, since patients treated for ED by the National Health Service (NHS) have increased in the first 6 months of 2020 as well.

Method

We used data from Wearesocial surveys on Internet users in the first 6 months of 2020 and the Google searches related to the query of “food disorders” and “body shaming.” The first results of a project of the Italian Ministry of Health on ED have been considered too.

Results

The social media users in July 2020 increased to 60% of the Italian population; a tendential increase in Google searches on these issues has emerged. Finally, new patients of NHS with ED showed a high increase in the first 6 months of 2020 (+40.9%).

Conclusion

Considering the contents diffused on the Internet, it is fundamental to watch over net usage in the adolescent population and those with ED, because massive access to social media can be considered almost as a risk factor.
Differential Effects of Cerebellar Degeneration on Feedforward versus Feedback Control across Speech and Reaching Movements
Authors: Parrell Benjamin , Kim Hyosub E. , Breska Assaf , Saxena Arohi , Ivry Richard
Published: August 2021

Errors that result from a mismatch between predicted movement outcomes and sensory afference are used to correct ongoing movements through feedback control and to adapt feedforward control of future movements. The cerebellum has been identified as a critical part of the neural circuit underlying implicit adaptation across a wide variety of movements (reaching, gait, eye movements, and speech). The contribution of this structure to feedback control is less well understood. Although it has recently been shown in the speech domain that individuals with cerebellar degeneration produce larger online corrections for sensory perturbations than control participants, similar behavior has not been observed in other motor domains. Currently, comparisons across domains are limited by different population samples and potential ceiling effects in existing tasks. To assess the relationship between changes in feedforward and feedback control associated with cerebellar degeneration across motor domains, we evaluated adaptive (feedforward) and compensatory (feedback) responses to sensory perturbations in reaching and speech production in human participants of both sexes with cerebellar degeneration and neurobiologically healthy controls. As expected, the cerebellar group demonstrated impaired adaptation in both reaching and speech. In contrast, the groups did not differ in their compensatory response in either domain. Moreover, compensatory and adaptive responses in the cerebellar group were not correlated within or across motor domains. These results point to a general impairment in feedforward control with spared feedback control in cerebellar degeneration. However, the magnitude of feedforward impairments and potential changes in feedback-based control manifest in a domain-specific manner across individuals.

SIGNIFICANCE STATEMENTThe cerebellum contributes to feedforward updating of movement in response to sensory errors, but its role in feedback control is less understood. Here, we tested individuals with cerebellar degeneration (CD), using sensory perturbations to assess adaptation of feedforward control and feedback gains during reaching and speech production tasks. The results confirmed that CD leads to reduced adaption in both domains. However, feedback gains were unaffected by CD in either domain. Interestingly, measures of feedforward and feedback control were not correlated across individuals within or across motor domains. Together, these results indicate a general impairment in feedforward control with spared feedback control in CD. However, the magnitude of feedforward impairments manifests in a domain-specific manner across individuals.
Some properties of compatible action graph
Authors: Shahoodh Mohammed khalid , M.S. Mohamad  , Yusof Yuhani , S.A. Sulaiman
Published: August 2021

In this paper, the compatible action graph for the finite cyclic groups of p-power order has been considered. The purpose of this study is to introduce some properties of the compatible action graph for finite p-groups.
Taguchi Analysis of Bonded Single-Lap Joint in Hemp Fiber Composite
Authors: Lokhande Rupesh , Deshpande Abhijeet , Mache Ashok
Published: August 2021

The adhesively bonded joints in composite structures are widely used in aerospace and automobile fields. Hemp epoxy composites are better alternative due to its lower specific gravity and higher toughness. . The joining process is inevitable in the application of such composites. The mechanical behaviour of such joints depends on the strength of the composite, adhesive strength and adhesion phenomenon between substrate and adhesive. The influence of overlap length, adhesive layer thickness and cure temperature on the performance of adhesive joints investigated experimentally. The influence of these parameters on the static behaviour of the joint was studied using design of experiment approach. L9 orthogonal array was used for experimental design. It was found that cure temperature of adhesive predominantly governs joint behaviour followed by adhesive layer thickness and overlap length. To obtain joint strength in the working limits, an empirical relationship between governing parameters and response was developed. Through the analysis it was observed that optimum strength of bonded joint was obtained with overlap length of 25 mm, adhesive layer thickness of 0.5 mm and cure temperature of 500C.
Implementation of Carbon Dioxide Gas Injection Method for Gas Recovery at Rashidpur Gas Field, Bangladesh
Authors: Khatun Fatema , Monir Md. Minhaj Uddin , Arham S.M. Nafefun , Ab Wahid Zularisam
Published: August 2021

Natural gas plays an important role for the economic development of Bangladesh. It is the primary options to satisfy the environmentally clean energy, whereas coal is a dirty energy source and oil creates an unhealthy environment. Bangladesh is the seventh-largest producer of natural gas in Asia. Gas supplies meet 56% of domestic energy demand. The proven natural gas reserve in Bangladesh is only 19.73 Tcf. The Rashidpur Gas Field (RGF) is located in the Sylhet Basin, Northeast Bangladesh. It is 35 km long and 7 km anticlinal structure and asymmetric in nature with steeper eastern flank (22˚ to 25˚) and gentler western flank (8˚ to 12˚). There are two gas zones in depth between 1380m to 2787m below surface. Sandstone reservoirs of Miocene-Pliocene age and are considered to have been originated shallow marine depositional environment. The reservoir porosity-permeability values are very good, with estimated gas initially in place (GIIP) of the RGF was 2.242 Tcf with 58% recovery, thus recording an initial gas reserve is 1.309 Tcf. Five gas producing wells (RP-1, 3, 4, 6 and 7) in the RGF are producing 50 MMscf gas per day. Due to the demand of natural gas with decreasing production rate, this enhanced natural gas plays a vital role in the national economy of the country. This research depicts the development of the daily production of the RGF from 50 MMscfd to 99 MMscfd using software from the existing production wells. Thus the natural gas in the RGF would be enhanced/recovered using carbon dioxide (CO2) gas injection by Enhanced Gas Recovery (EGR) method from the RGF reservoir. Applying this method would play a vital role to increase the daily production rate of the RGF.
The Integral Approach to Safety
Authors: Bin Abu Bakar Dzulqarnain , Binti Ismail Norazura
Published: August 2021

There is a need to balance the reliance on a traditional OSHMS being implicitly adhered to against the human contribution factor. The aim of this qualitative study paper is to describe and discuss the existing leadership styles and approaches that are being practiced and past initiatives that have produced results in OSH performance. The snowball sampling review method of literature published between years 1997 through 2016 was applied to produce the observations and discussion. Despite the progress that is being realized, there needs to be a different approach if a sustainable performance breakthrough in OSH performance is to be achieved. The integral approach leans towards transformational leadership style and attempts to acknowledge that the subjective and objective, personal and collective factors are all equally important towards establishing wholesome and robust OSHMS. Traditional reliance on discipline and rule-based compliance needs to be tempered with an interdependent realization and awareness from the individual carrying out a task that they are ultimately responsible for their safety. Leadership and management will then need to take on the role and challenge of providing support and resources to enable the development of this self-accountable culture.
A Wireless Smart Sensor Network for Flood Management Optimization
Authors: Alfarra Hossam Adden , Alsibai Mohammed Hayyan
Published: August 2021

Recent development in the sensing technologies and wireless sensor networks has encouraged many innovative applications in disaster management and forecasting. Flood is one of the most dangerous natural disasters that occurs frequently in south Asia. Therefore, water level monitoring and flood early prediction, play an important role in lives and properties saving. In this paper, an optimized Flood Warning System (FWS) is presented. The system is based on multi parameters Wireless Smart Sensor Network (WSSN) for early flood warning. WSSN performs pre-processing procedures at sensor level before sending the data to a base data analyzing station. This pre-processing step is to improve the reliability, data quality and transmission quality. For the purpose of validation, the proposed method is applied using two parameters: The water level (L) and streamflow of water (R) in rivers. The proposed system provides early flood detection by continuously measuring R and L in real-time. The collected data is to be used to predict flood time and place. Data is exchanged among sensors in real-time. Pre-analyzing is performed and reports are sent to the base station only if the analysis gave a high risk level. The main purpose is to cut down the data size. Analysis and simulation showed that the data size is improved significantly using this method. Calculations considers real cases on a part of Pahang River (Sungai Pahang).
Design and Fabrication of an Improved Low Cost Biomass Briquetting Machine Suitable for use in Nigeria
Authors: Kelly Orhorhoro Ejiroghene , Micheal Chukudi Okonkwo , Oghenekevwe Oghoghorie , Erhire Onogbotsere Monday
Published: August 2021

Briquetting is a mechanical compaction process for increasing the density of bulky materials. Nigeria’s current energy requirements for industrial, commercial and domestic needs cannot be met by our national electric grid which at present can only generate 5000MW for Nigeria growing population. In this research work, an improved low cost biomass briquetting machine was successfully designed and fabricated for local use in Nigeria. Preliminary tests were carried out to determine the compression ratio required (compression pressure) and the type of mould to be used. Design considerations that guided in the generation of a conceptual design that satisfy the functional requirements were established. The briquette machine design was based on mechanical (hydraulic or piston) compression principle. The machine is operated manually by a hydraulic system to generate pressure required for compression. The results obtained from the design calculation reveal that force exerted on plunger (F1) is 490.5N, total compaction force of 355.03N, total compaction pressure of 2MPa, maximum bending stress of 456MPa, projected area of 0.015m2, total force acting upward exerted by the spring is 654N and a pressure of 4.34MPa is exerted on the compression piston. Analysis carried out on the produced briquette from the biomass (elephant grass) by the fabricated machine reveals that the machine performance is satisfactory. The biomass (elephant grass) had calorific values of 14011.2KJ/kg before briquetting. The calorific value increased to 15013.9KJ/Kg after formation of briquette. This increase is partly attributed to the moisture content of the biomass.