bluuebunny/crossref_metadata_2025 huggingface dataset:
Strengths-Based Job Crafting and Employee Creativity: The Role of Job Self-Efficacy and Workplace Status
Authors: Yang Zheng , Liu Pingqing , Cui Zunkang
Published: December 2021

While argued to be fostering creativity, the effect of job crafting on creativity often turned out to be less effective than expected. The reason is that most existing studies focused on the top-down job design interventions. We proposed an elaborated theoretical model to explain the influence of strengths-based job crafting (SJC) on employee creativity (EC). Specifically, we examined the mediating effect of job self-efficacy (JSE) and the moderating effect of workplace status (WP) based on self-affirmation theory. A sample of 480 employees and their supervisors completed a battery of questionnaires. The results revealed that strengths-based job crafting was positively related to employee creativity, with job self-efficacy acting as a mediator for this relationship. Workplace status moderated both the direct and the indirect effects of job self-efficacy. For employees with a higher workplace status, strengths-based job crafting may generate more forces to promote employee creativity. The results suggest that strengths-based job crafting and workplace status can inspire employee creativity through a self-affirmation process.
Analysis of the Emails From the Dutch Web-Based Intervention “Alcohol de Baas”: Assessment of Early Indications of Drop-Out in an Online Alcohol Abuse Intervention
Authors: Smink Wouter A. C. , Sools Anneke M. , Postel Marloes G. , Tjong Kim Sang Erik , Elfrink Auke , Libbertz-Mohr Lukas B. , Veldkamp Bernard P. , Westerhof Gerben J.
Published: December 2021

Nowadays, traditional forms of psychotherapy are increasingly complemented by online interactions between client and counselor. In (some) web-based psychotherapeutic interventions, meetings are exclusively online through asynchronous messages. As the active ingredients of therapy are included in the exchange of several emails, this verbal exchange contains a wealth of information about the psychotherapeutic change process. Unfortunately, drop-out-related issues are exacerbated online. We employed several machine learning models to find (early) signs of drop-out in the email data from the “Alcohol de Baas” intervention by Tactus. Our analyses indicate that the email texts contain information about drop-out, but as drop-out is a multidimensional construct, it remains a complex task to accurately predict who will drop out. Nevertheless, by taking this approach, we present insight into the possibilities of working with email data and present some preliminary findings (which stress the importance of a good working alliance between client and counselor, distinguish between formal and informal language, and highlight the importance of Tactus' internet forum).
Use of Psychoeducation for Psychotic Disorder Patients Treated With Modern, Long-Acting, Injected Antipsychotics
Authors: Ventriglio Antonio , Petito Annamaria , Castaldelli-Maia João Maurício , Torales Julio , Sannicandro Valeria , Milano Eleonora , Iuso Salvatore , Bellomo Antonello
Published: December 2021

Introduction: There is an increased risk of adverse metabolic effects of some modern antipsychotic drugs, and concern that long-acting, injected preparations of them may increase such risk. We now report on clinical and metabolic outcomes in patient-subjects diagnosed with affective and non-affective psychotic disorders following exposure to psychoeducation on metabolic risks of modern antipsychotics followed by treatment with long-acting atypical injected antipsychotics over 6-months.

Materials and Methods: 85 psychotic disorder outpatients (42 affective [AP]; 43 non-affective [NAP]) at the University of Foggia were treated with long-acting, injected, second-generation antipsychotics in association with a set of psychoeducational sessions concerning general health and potential effects of antipsychotic drug treatments. They were evaluated at baseline and six months.

Results: Initially, NAP subjects reported higher ratings of positive and negative symptoms than AP subjects, were more likely to receive risperidone or paliperidone, with higher CPZ-eq doses of antipsychotics (294.0 ± 77.8 vs. 229.3 ± 95.8 mg/day), and shorter QTc electrocardiographic recovery intervals. During the 6-month follow-up, ratings of treatment-adherence improved through overall (+8.75%), and symptom-ratings decreased (−7.57%) as did Body-Mass Index (−2.40%; all p ≤ 0.001). Moreover, serum levels of fasting glucose, hemoglobin glycosylation, cholesterol and prolactin concentrations all decreased, with little difference between subjects with AP vs. NAP.

Discussion and Conclusions: A psychoeducational program was associated with consistent improvement in psychotic symptoms and several metabolic and physiological measures, as well as with treatment-adherence during six months of treatment with long-acting, injected, second-generation antipsychotics, in association with both affective and non-affective psychotic disorders.
The Role of Leadership in Public Sector Innovation: A Systematic Review and Meta-Analysis of the Management of COVID-19 in Asian Countries
Authors: Sazzad Faizus , Rajan V. Priya , Demircioglu Mehmet Akif
Published: December 2021

Strong leadership in public sector innovation can empower governments to address community challenges in new ways in light of the challenges posed by the global coronavirus pandemic. Coronavirus management policy, pandemic responses, needs, and options are reflected in various Asian countries in respective published literature, but a summarized synthesis is not available. Using a systematic review approach (PRISMA), this study has analyzed the role of leadership in public sector innovation in COVID-19 management and synthesized 23 articles from 23 different Asian countries. In the light of available data, public sector innovation (PSI) and the role played by the leadership of each country' have been found to be largely inter-dependent. The current review provides a cross-section of the ongoing nature of the pandemic, as management responses and trend data in the countries are still emerging or evolving. Additionally, our study contributes a current state report regarding the barriers facing the leadership of Asian countries in mitigating the global pandemic through PSI. Our study found that a strong political leadership presence combined with a technocratic approach and a highly-skilled public sector workforce, could lead to more tremendous success in managing the outbreak. Furthermore, religious leadership was also found to have a potentially significant role in COVID-19 management strategies.
Relationship Between Lifestyle Habits and Health-Related Quality of Life of Recently Diagnosed Breast Cancer Patients: A Comparison Between Younger and Older Women in China
Authors: Zheng Chao , Yu Li-Xiang , Jia Hong-Ying , Cui Shu-De , Tian Fu-Guo , Fan Zhi-Min , Geng Cui-Zhi , Cao Xu-Chen , Yang Zhen-Lin , Wang Xiang , Liang Hong , Wang Shu , Jiang Hong-Chuan , Duan Xue-Ning , Wang Hai-Bo , Li Guo-Lou , Wang Qi-Tang , Zhang Jian-Guo , Jin Feng , Tang Jin-Hai , Li Liang , Zhu Shi-Guang , Zuo Wen-Shu , Wang Fei , Zhou Fei , Xiang Yu-Juan , Guo Ming-Ming , Wang Yong-Jiu , Huang Shu-Ya , Liu Li-Yuan , Yu Zhi-Gang
Published: December 2021

Objective: The aim of this study was to evaluate the relationship between lifestyle habits and health-related quality of life (HRQoL) among different ages who were initially diagnosed with breast cancer (within the first 2 weeks) and to determine the contribution of lifestyle habits factors on HRQoL.

Methods: Patients with breast cancer were recruited from 22 hospitals in 11 provinces or municipalities in northern and eastern China. The Functional Assessment of Cancer Therapy-Breast Cancer (FACT-B) was used to measure HRQoL. Chi-square test, ANOVA, and multivariable generalized linear models were conducted to identify the differences in HRQoL between two age groups (age <50 years and ≥50 years) and to evaluate the contribution of lifestyle habits factors on HRQoL of patients with breast cancer.

Results: About 1,199 eligible patients with breast cancer were used for analysis. Younger women (aged <50 years) appeared to show lower scores than older women (aged ≥50 years) in HRQoL subscales, including emotional well-being (p = 0.003), functional well-being (p = 0.006), breast cancer subscale (p = 0.038), and FACT-B Total scores (p = 0.028). Tea and alcohol consumption and being very satisfied with sleep and current life were the strongest predictors of higher HRQoL in younger group. Meanwhile, no coffee consumption, frequent participation in physical activities, high sleep satisfaction, and current life satisfaction were the key predictors of higher HRQoL in older women with breast cancer.

Conclusion: The relationship of the nine lifestyle habit items with HRQoL differed among younger and older women. The associated variable of low HRQoL can help clinicians take intervention early in order to improve the prognosis of patients with breast cancer.
Review and Implications of Intergenerational Communication and Social Support in Chronic Disease Care and Participation in Health Research of Low-Income, Minority Older Adults in the United States
Authors: Vaccaro Joan A. , Gaillard Trudy R. , Marsilli Ramces L.
Published: December 2021

Background: Health disparities disproportionally affect Black and Hispanic older US adults. Health research is needed to understand and eliminate these disparities; however, older adults, and particularly Black and Hispanic/Latino older adults are underrepresented in health research. Adult children have influenced health behavior and health outcomes of their older parents in several demographics in the US. Analysis of these studies can lead to a model for the development of interventions aimed at improving health and healthcare participation of older Black and Hispanic US adults.

Objectives: To review the role of intergenerational communication and social support in health behavior, health research, and health outcomes for older adults and to apply these findings toward a model for health interventions for Black and Hispanic US older adults.

Methods: An analytical narrative review and application toward an intervention model.

Results: Key topic areas were reviewed and analyzed by examining studies that applied forms of intergenerational communication and/or intergenerational social support with the goal of either improving health, disease management and/or participation in health research in populations world-wide. Next, a model for providing health interventions in older Black and Hispanic US adults was developed using strategies gleaned from the findings.

Conclusion: A model for health intervention for Black and Hispanic/Latino US older adults was presented based on an analytical review and intergenerational communication and/or social support. Qualitative data are necessary to understand the enablers and barriers of intergenerational communication and social support to improve health outcomes in these populations.
A Summary of Online Enquiries Submitted to Anti-doping Hotline 2005–2018
Authors: Ekström Lena , Broström Susanne , Dahl Marja-Liisa , Börjesson Annica
Published: December 2021

Anabolic Androgenic Steroid (AAS) abuse in the society is considered a health problem and has been associated with cardiovascular toxicity, endocrine disruption, as well as psychiatric symptoms such as aggression and cognitive dysfunction. Men and women abusing AAS, as well as persons in close relationship to AAS abusers, may encounter concerns. Subsequently, the Anti-Doping Hotline was formed 1993 to answers questions about doping in the society. Here we have reviewed 7,123 enquiries posted on the Anti-Doping Hotline website between 2005 and 2018 to see what type of questions were raised. Most questions (n = 2,924) involved AAS, 60% from abusers themselves, and 17% from a person close to an AAS abusers. Only 2.3% of the questions concerned AAS abusing women. Of the AAS specific questions most were from persons who sought personal advice regarding risks and side effects. Notably, the AAS abusers themselves were concerned about somatic side effects (e.g., gynecomastia) and problems related to the AAS injection. The persons in close relationship to an AAS abusers on the other hand, expressed concerns about psychiatric changes including mood swings and aggressivity. In addition to AAS, 26 and 13% of the questions involved dietary supplements and other doping substances, respectively. A gradual decrease of questions regarding ephedrine was noted, whereas the numbers of SARMs related questions increased during this time. Our results show that there is a continuous need to provide medical, nursing, and social support and counseling to AAS abusers and their next of kin.
Digital Twins of Urban Air Quality: Opportunities and Challenges
Authors: Topping David , Bannan Thomas J. , Coe Hugh , Evans James , Jay Caroline , Murabito Ettore , Robinson Niall
Published: December 2021

The increasing amount of data collected about the environment brings tremendous potential to create digital systems that can predict the impact of intended and unintended changes. With growing interest in the construction of Digital Twins across multiple sectors, combined with rapid changes to where we spend our time and the nature of pollutants we are exposed to, we find ourselves at a crossroads of opportunity with regards to air quality mitigation in cities. With this in mind, we briefly discuss the interplay between available data and state of the science on air quality, infrastructure needs and areas of opportunities that should drive subsequent planning of the digital twin ecosystem and associated components. Data driven modeling and digital twins are promoted as the most efficient route to decision making in an evolving atmosphere. However, following the diverse data streams on which these frameworks are built, they must be supported by a diverse community. This is an opportunity to build a collaborative space to facilitate closer working between instrument manufacturers, data scientists, atmospheric scientists, and user groups including but not limited to regional and national policy makers.
Persymmetric Adaptive Union Subspace Detection
Authors: Pan Liyan , Gao Yongchan , Ye Zhou , Lv Yuzhou , Fang Ming
Published: December 2021

This paper addresses the detection of a signal belonging to several possible subspace models, namely, a union of subspaces (UoS), where the active subspace that generated the observed signal is unknown. By incorporating the persymmetric structure of received data, we propose three UoS detectors based on GLRT, Rao, and Wald criteria to alleviate the requirement of training data. In addition, the detection statistic and classification bound for the proposed detectors are derived. Monte-Carlo simulations demonstrate the detection and classification performance of the proposed detectors over the conventional detector in training-limited scenarios.
Spatial Arrangement and Biofertilizers Enhance the Performance of Legume—Millet Intercropping System in Rainfed Areas of Southern India
Authors: Singh Devesh , Mathimaran Natarajan , Sekar Jegan , Ramalingam Prabavathy Vaiyapuri , Perisamy Yuvaraj , Raju Kathiravan , Raj Rengalakshmi , King Israel Oliver , Nanjundegowda Thimmegowda Matadadoddi , Narayanswamy Manjunatha Baiyapalli , Chikkegowda Bhavitha Nayakanahalli , Siddegowda Savitha Matakere , Bagyaraj Davis Joseph , Mäder Paul , Boller Thomas , Kahmen Ansgar
Published: December 2021

Intercropping is a well-established practice to enhance the yield in low-input agriculture, and beneficial microbes such as arbuscular mycorrhizal fungi (AMF) combined with plant growth promoting rhizobacteria are being used as an effective and sustainable measure to improve yields. In this study, we tested if biofertilizers can not only enhance the yield of crops in monoculture as has previously been demonstrated but can also enhance the yield of intercropping systems. We hypothesized that because AMF can form common mycorrhizal networks (CMN) that can transfer nutrients and water between different plant species, biofertilization can balance belowground competition between crop species and promote thus overall yields in intercropping systems. In our study, we used a pigeon pea (PP)—finger millet (FM) intercropping system that we grew for two consecutive growing seasons (2016/17 and 2017/18) at two contrasting sites in Bengaluru and Kolli Hills, India. We also tested if the spatial arrangement (i.e., different arrangement of component plants with similar plant density in intercropping system) of intercropped plants, using either a row-wise or a mosaic design, influences the effect of biofertilizers on yield and water relations of the PP-FM intercropping system. Our results demonstrate that intercropping can improve the straw and grain yield of PP and FM compared to the respective monocultures and that intercropping effects vary depending on the site characteristic such as climate and soil type. The spatial arrangement of component plants affected the total, straw, and grain biomass in intercropping treatments, but this effect also varied across sites. Most importantly, the results from the 2017/18 growing season clearly demonstrated a positive effect of biofertilizer on biomass yield, and this effect was irrespective of site, spatial arrangement, mixed or monoculture. Our study therefore shows that yield increase in intercropping systems can further be improved through the application of biofertilizers.
An Updated Meta-Analysis of the Efficacy and Safety of Prostatic Artery Embolization vs. Transurethral Resection of the Prostate in the Treatment of Benign Prostatic Hyperplasia
Authors: Xu Zhunan , Zhou Zhongbao , Mu Yingmei , Cai Tong , Gao Zhenli , Liu Lingling
Published: December 2021

Background: Prostatic artery embolization (PAE) in the treatment of benign prostatic hyperplasia (BPH) has been introduced into clinical practice, but conclusive evidence of efficacy and safety has been lacking.

Objective: To compare the efficacy and safety of prostatic artery embolization (PAE) vs. transurethral resection of prostate (TURP), we performed a meta-analysis of clinical trials.

Methods: We searched randomized controlled trials (RCTs) from Pubmed, Embase, Wanfang, and CNKI from January 2000 to December 2020 and used RevMan 5.0 to analyze the data after five RCTs were included.

Results: The reducing of prostate volume (PV) [Median mean (MD) 14.87; 95% confidence interval (CI) 7.52–22.22; P < 0.0001] and the increasing of maximum flow rate in free uroflowmetry (Qmax) (MD 3.73; 95% CI 0.19–7.27; P = 0.004) were more obvious in TURP than in PAE; however, the rate of lower sexual dysfunction [odds ratio (OR) 0.12; 95% CI 0.05–0.30; P < 0.00001] was lower in PAE compared with TURP. Meanwhile, no conspicuous difference in International Prostate Symptoms Score (IPSS) score (MD 1.42; 95% CI −0.92 to 3.75; P = 0.23), quality of life (Qol) score (MD 0.21; 95% CI −0.31 to 0.73; P = 0.43), post void residual (PVR) (MD 21.16; 95% CI −5.58 to 47.89; P = 0.12), prostate-specific antigen (PSA) (MD 0.56; 95% CI −0.15 to 1.27; P = 0.12), and complications (OR 0.90; 95% CI 0.20–4.05; P = 0.89) between PAE and TURP group was shown.

Conclusion: PAE may replace TURP as an alternative treatment for Benign prostatic hyperplasia (BPH) patients who do not want to have surgery or with operational contraindications.
Evaluation of Potency and Duration of Immunity Elicited by a Multivalent FMD Vaccine for Use in South Africa
Authors: Peta Faith R. M. , Sirdar M. M. , van Bavel Peter , Mutowembwa P. B. , Visser N. , Olowoyo J. , Seheri M. , Heath Livio
Published: December 2021

South Africa (SA) experiences sporadic foot and mouth disease (FMD) outbreaks irrespective of routine prophylactic vaccinations of cattle using imported commercial vaccines. The problem could be mitigated by preparation of vaccines from local virus strains related to those circulating in the endemically infected buffalo populations in the Kruger National Park (KNP). This study demonstrates the individual number of protective doses (PD) of five vaccine candidate strains after homologous virus challenge, as well as the vaccines safety and onset of humoral immunity in naïve cattle. Furthermore, the duration of post-vaccination immunity over a 12-month period is shown, when a multivalent vaccine prepared from the five strains is administered as a primary dose with or without booster vaccinations. The five monovalent vaccines were shown to contain a 50% PD between 4 and 32, elicit humoral immunity with antibody titers ≥2.0 log10 from day 7 post-vaccination, and cause no adverse reactions. Meanwhile, the multivalent vaccine elicited antibody titers ≥2.0 log10 and clinical protection up to 12 months when one or two booster vaccinations were administered within 6 months of the primary vaccination. An insignificant difference between the application of one or two booster vaccinations was revealed. Owing to the number of PDs, we anticipate that the multivalent vaccine could be used successfully for prophylactic and emergency vaccinations without adjustment of the antigen payloads. Furthermore, a prophylactic vaccination regimen comprising primary vaccination of naïve cattle followed by two booster vaccinations 1.5 and 6 months later could potentially maintain herd immunity over a period of 12 months.
Comparative Enhancer Map of Cattle Muscle Genome Annotated by ATAC-Seq
Authors: Cao Xiukai , Cheng Jie , Huang Yongzhen , Lan Xianyong , Lei Chuzhao , Chen Hong
Published: December 2021

Annotating regulatory elements could benefit the interpretation of the molecular mechanism of genome-wide association study (GWAS) hits. In this work, we performed transposase-accessible chromatin with sequencing (ATAC-seq) to annotate the cattle muscle genome's functional elements. A total of 10,023 and 11,360 peaks were revealed in muscle genomes of adult and embryo cattle, respectively. The two peak sets produced 8,850 differentially accessible regions (DARs), including 2,515 promoters and 4,319 putative enhancers. These functional elements were associated with the cell cycle, muscle development, and lipid metabolism. A total of 15 putative enhancers were selected for a dual-luciferase reporter assay, and 12 of them showed enhancer activity in cattle myoblasts. Interestingly, the GeneHancer database has annotated the interactions of eight active enhancers with gene promoters, such as embryo-specific peak1053 (log2FC = 1.81, embryo/adult, E/A) with ligand-dependent nuclear receptor corepressor-like protein (LCORL) and embryo-specific peak4218 (log2FC = 1.81) with FERM domain-containing 8 (FRMD8). A total of 295 GWAS loci from the animal QTL database were mapped to 183 putative enhancers, including rs109554838 (associated with cattle body weight and average daily gain) to peak1053 and rs110294629 (associated with beef shear force and tenderness score) to peak4218. Notably, peak4218 has been found to be involved in mouse embryo development. Deleting peak4218 clearly reduced luciferase activity (P = 3.30E-04). Our comparative enhancer map is expected to benefit the area of beef cattle breeding.
Fishnition: Developing Models From Cognition Toward Consciousness
Authors: Droege Paula , Schwob Natalie , Weiss Daniel J.
Published: December 2021

A challenge to developing a model for testing animal consciousness is the pull of opposite intuitions. On one extreme, the anthropocentric view holds that consciousness is a highly sophisticated capacity involving self-reflection and conceptual categorization that is almost certainly exclusive to humans. At the opposite extreme, an anthropomorphic view attributes consciousness broadly to any behavior that involves sensory responsiveness. Yet human experience and observation of diverse species suggest that the most plausible case is that consciousness functions between these poles. In exploring the middle ground, we discuss the pros and cons of “high level” approaches such as the dual systems approach. According to this model, System 1 can be thought of as unconscious; processing is fast, automatic, associative, heuristic, parallel, contextual, and likely to be conserved across species. Consciousness is associated with System 2 processing that is slow, effortful, rule-based, serial, abstract, and exclusively human. An advantage of this model is the clear contrast between heuristic and decision-based responses, but it fails to include contextual decision-making in novel conditions which falls in between these two categories. We also review a “low level” model involving trace conditioning, which is a trained response to the first of two paired stimuli separated by an interval. This model highlights the role of consciousness in maintaining a stimulus representation over a temporal span, though it overlooks the importance of attention in subserving and also disrupting trace conditioning in humans. Through a critical analysis of these two extremes, we will develop the case for flexible behavioral response to the stimulus environment as the best model for demonstrating animal consciousness. We discuss a methodology for gauging flexibility across a wide variety of species and offer a case study in spatial navigation to illustrate our proposal. Flexibility serves the evolutionary function of enabling the complex evaluation of changing conditions, where motivation is the basis for goal valuation, and attention selects task-relevant stimuli to aid decision-making processes. We situate this evolutionary function within the Temporal Representation Theory of consciousness, which proposes that consciousness represents the present moment in order to facilitate flexible action.
Genetic Diversity and Prevalence of Porcine Circovirus Type 2 in China During 2000-2019
Authors: Li Ning , Liu Jing , Qi Jiali , Hao Feng , Xu Lei , Guo Kangkang
Published: December 2021

As the major pathogen for porcine circovirus-associated disease (PCVAD), porcine circovirus type 2 (PCV2) is no longer treated as an emerging virus anymore. The wide distribution of PCV2 infection in China causes huge economic losses in the swine industry. Currently, it is generally believed that PCV2 has eight genotypes (PCV2a to PCV2h), with PCV2a, PCV2b, and PCV2d being widely distributed. To comprehensively explore the genetic diversity and prevalence of PCV2 in China, PCV-2 sequences submitted from China in the GenBank database were retrieved. With a total of 714 PCV2 strains were retrieved, we found that early-submitted PCV2 sequences were mainly collected from coastal provinces in the southeast part of China, which may indicate PCV2 was initially circulating in those regions. From 2002 to 2008, PCV2b was the dominant prevalent genotype in those retrieved sequences. From 2009, PCV2d became the dominant genotype in those sequences, dropping a hint that a potential shift of PCV2b to PCV2d might occur in 2009, which is similar to the patterns at the global level. In addition to the PCV2a, PCV2b, and PCV2d genotypes, novel strains were also characterized. We further revealed that the amino acid sequences consistency of PCV2a Cap is higher than those in other genotypes. Together, this study provided clues for the possible prevalent genotypes and dynamics of genetic diversity in China from 2000 to 2019.
The Long-Term Effectiveness of Interventions Addressing Mental Health Literacy and Stigma of Mental Illness in Children and Adolescents: Systematic Review and Meta-Analysis
Authors: Freţian Alexandra Maria , Graf Patricia , Kirchhoff Sandra , Glinphratum Gloria , Bollweg Torsten M. , Sauzet Odile , Bauer Ullrich
Published: December 2021

Objectives: This study aims to provide a systematic review and meta-analysis of the literature on the long-term effects of interventions addressing children’s and adolescents’ mental health literacy and/or stigmatizing attitudes.

Methods: Articles in English or German published between January 1997 and May 2020 were retrieved from five databases, leading to a total of 4,375 original articles identified.

Results: 25 studies were included after applying exclusion criteria, 13 of which were eligible for meta-analysis. The overall average of the follow-up period was about 5 months. Long-term improvements were sustained for mental health literacy, d = 0.48, 95% CI = (0.34, 0.62), as well as for stigmatizing attitudes, d = 0.30, 95% CI = (0.24, 0.36), and social distance, d = 0.16, 95% CI = (0.03, 0.29). The combination of educational and contact components within interventions led to worse results for mental health literacy, but not stigmatizing attitudes or social distance.

Conclusion: Interventions targeting children and adolescents generally have a brief follow-up period of an average of 5 months. They show a stable improvement in mental health literacy, but are to a lesser degree able to destigmatize mental illness or improve social distance.
Metaheuristics in the Humanitarian Supply Chain
Authors: Santana Robles Francisca , Hernández-Gress Eva Selene , Hernández-Gress Neil , Granillo Macias Rafael
Published: December 2021

Everyday there are more disasters that require Humanitarian Supply Chain (HSC) attention; generally these problems are difficult to solve in reasonable computational time and metaheuristics (MHs) are the indicated solution algorithms. To our knowledge, there has not been a review article on MHs applied to HSC. In this work, 78 articles were extracted from 2016 publications using systematic literature review methodology and were analyzed to answer two research questions: (1) How are the HSC problems that have been solved from Metaheuristics classified? (2) What is the gap found to accomplish future research in Metaheuristics in HSC? After classifying them into deterministic (52.56%) and non-deterministic (47.44%) problems; post-disaster (51.28%), pre-disaster (14.10%) and integrated (34.62%); facility location (41.03%), distribution (71.79%), inventory (11.54%) and mass evacuation (10.26%); single (46.15%) and multiple objective functions (53.85%), single (76.92%) and multiple (23.07%) period; and the type of Metaheuristic: Metaphor (71.79%) with genetic algorithms and particle swarm optimization as the most used; and non-metaphor based (28.20%), in which search algorithms are mostly used; it is concluded that, to consider the uncertainty of the real context, future research should be done in non-deterministic and multi-period problems that integrate pre- and post-disaster stages, that increasingly include problems such as inventory and mass evacuation and in which new multi-objective MHs are tested.
Multi-Fidelity Optimization of a Composite Airliner Wing Subject to Structural and Aeroelastic Constraints
Authors: Kafkas Angelos , Kilimtzidis Spyridon , Kotzakolios Athanasios , Kostopoulos Vassilis , Lampeas George
Published: December 2021

Efficient optimization is a prerequisite to realize the full potential of an aeronautical structure. The success of an optimization framework is predominately influenced by the ability to capture all relevant physics. Furthermore, high computational efficiency allows a greater number of runs during the design optimization process to support decision-making. The efficiency can be improved by the selection of highly optimized algorithms and by reducing the dimensionality of the optimization problem by formulating it using a finite number of significant parameters. A plethora of variable-fidelity tools, dictated by each design stage, are commonly used, ranging from costly high-fidelity to low-cost, low-fidelity methods. Unfortunately, despite rapid solution times, an optimization framework utilizing low-fidelity tools does not necessarily capture the physical problem accurately. At the same time, high-fidelity solution methods incur a very high computational cost. Aiming to bridge the gap and combine the best of both worlds, a multi-fidelity optimization framework was constructed in this research paper. In our approach, the low-fidelity modules and especially the equivalent-plate methodology structural representation, capable of drastically reducing the associated computational time, form the backbone of the optimization framework and a MIDACO optimizer is tasked with providing an initial optimized design. The higher fidelity modules are then employed to explore possible further gains in performance. The developed framework was applied to a benchmark airliner wing. As demonstrated, reasonable mass reduction was obtained for a current state of the art configuration.
Exploring the Biotechnological Value of Marine Invertebrates: A Closer Look at the Biochemical and Antioxidant Properties of Sabella spallanzanii and Microcosmus squamiger
Authors: Pan Yu-Lun , Rodrigues Maria João , Pereira Catarina G. , Engrola Sofia , Colen Rita , Mansinhos Inês , Romano Anabela , Andrade Paula B. , Fernandes Fátima , Custódio Luísa
Published: December 2021

Sabella spallanzanii and Microcosmus squamiger were profiled for proximate composition, minerals, amino acids, fatty acids (FA), carotenoids, radical scavenging activity on the 2,2-diphenyl-1- picrylhydrazyl (DPPH) radical, oxygen radical absorbance capacity (ORAC) and iron and copper chelating properties. Microcosmus squamiger had the highest level of moisture and crude protein, S. spallanzanii was enriched in crude fat and ash. Both species had similar levels of carbohydrates and energy. There was a prevalence of arginine and glycine in S. spallanzanii, and of taurine in M. squamiger. The most abundant minerals in both species were Na, Ca, and K. The methanol extract of S. spallanzanii had metal chelating properties towards copper and iron, while the methanol extract of M. squamiger was able to chelate copper. M. squamiger extracts had similar ORAC values. Fucoxanthinol and fucoxanthin were the major carotenoids in the M. squamiger dichloromethane extract. Saturated FA were more abundant than unsaturated ones in methanol extracts, and unsaturated FA prevailed in the dichloromethane extracts. Palmitic acid was the predominant FA in methanol extracts, whereas eicosapentaenoic (EPA) and dihomo-γ-linolenic acids were the major compounds in dichloromethane extracts. Low n-6/n-3 ratios were obtained. Our results suggests that both species could be explored as sources of bioactive ingredients with multiple applications.
Seeing beyond a Dilated Proventriculus: Diagnostic Tools for Proventricular Dilatation Disease in Psittacine Birds
Authors: Leal de Araújo Jeann , Rech Raquel Rubia
Published: December 2021

Proventricular dilatation disease (PDD) is a life-threatening neurological disease caused by parrot bornaviruses (PaBVs) that affects several species worldwide. PDD can be clinically manifested as either a central nervous system condition or a gastrointestinal condition if the nerves and ganglia of the gastrointestinal tract are compromised. We intend to provide a concise review for veterinary clinicians and diagnosticians with focus on the main tools available for PDD diagnosis, including gross and histopathology, immunohistochemistry, molecular techniques and serology. We suggest that a combination of different strategies can increase the success of diagnostic outcomes, as tools such as reverse transcription polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA) can be implemented for identification of bornaviral infections in live patients, and gross pathology, histopathology, immunohistochemistry and RT-PCR can provide reliable results for postmortem diagnosis of PDD.
Mannan Oligosaccharide Enhanced the Growth Rate, Digestive Enzyme Activity, Carcass Composition, and Blood Chemistry of Thinlip Grey Mullet (Liza ramada)
Authors: Magouz Fawzy I. , Bassuini Mohamed I. , Khalafalla Malik M. , Abbas Ramy , Sewilam Hani , Aboelenin Salama Mostafa , Soliman Mohamed Mohamed , Amer Asem A. , Soliman Ali A. , Van Doan Hien , Dawood Mahmoud A. O.
Published: December 2021

Mannan oligosaccharide (MOS) is prebiotic with high functionality in aquaculture. The current study investigated the potential roles of MOS on the growth performance, digestive enzyme activity, carcass composition, and blood chemistry of Thinlip grey mullet (Liza ramada). Four tested diets with 34.49% crude protein and 6.29% of total lipids were prepared and fortified with 0, 0.5, 1, and 2% MOS. Fish of initial weight = 5.14 ± 0.11 g/fish were distributed in 12 hapas (0.5 × 0.5 × 1 m) at 15 fish per hapa (triplicates) and fed the test diets to the satiation level two times a day (08:00 and 15:00) for eight weeks. At the end of the trial, all fish were weighed individually for growth performance calculation. Blood was collected to check blood chemistry traits, and intestines were dissected for digestive enzyme analysis. Fish treated with MOS had marked enhancement in the final body weight, feed conversion ratio, protein gain, and protein retention regardless of inclusion dose (p < 0.05). The weight gain, specific growth rate, and protein efficiency ratio were meaningfully enhanced by including MOS at 0.5 and 1%, followed by fish fed with 2% MOS, while the lowest values were in the control group (p < 0.05). Insignificant influences of MOS were seen on the chemical composition of carcass components (moisture, crude protein, total lipids, and ash) (p > 0.05). Fish treated with MOS at 0.5 and 1% had marked enhancement in the amylase, lipase, and protease activities regardless of inclusion dose (p < 0.05). The blood total protein and albumin levels were meaningfully enhanced by including MOS at 0.5 and 1%, followed by fish fed with 2% MOS, while the lowest values were in the control group (p < 0.05). The blood globulin was significantly enhanced in fish fed 1% MOS than fish treated with 0, 0.5, and 2% of MOS (p < 0.05). The blood lysozyme activity was meaningfully enhanced by including MOS at 1%, followed by fish treated with 0.5 and 2%, while the lowest values were in the control group (p < 0.05). Phagocytic activity and phagocytic index were markedly improved in fish treated with 1 and 2% MOS, followed by those fed 0.5% compared with fish fed MOS-free diet (p < 0.05). Superoxide dismutase and glutathione peroxidase were markedly improved in fish treated with 1, and 2% MOS, followed by those fed 0.5% compared with fish fed MOS-free diet (p < 0.05). Dietary MOS (0.5, 1, and 2%) meaningfully enhanced catalase activity while decreased the malondialdehyde concentration (p < 0.05). In summary, dietary MOS is required at 0.5–1% for enhancing the growth rate, feed efficiency, digestive enzyme activity, blood chemistry, and antioxidative capacity of grey mullet.
Range Sizes of the World’s Mammals, Birds, and Amphibians from the Mid-Holocene to the Industrial Period
Authors: Beyer Robert , Manica Andrea
Published: December 2021

Anthropogenic land use and climate change in the Industrial age have had substantial impacts on the geographic ranges of the world’s terrestrial animal species. How do these impacts compare against those in the millennia preceding the Industrial era? Here, we combine reconstructions of global climate and land use from 6000 BCE to 1850 CE with empirical data on the spatial distributions and habitat requirements of 16,919 mammal, bird, and amphibian species to estimate changes in their range sizes through time. We find that land use had only a small, yet almost entirely negative impact during most of the study period, whilst natural climatic variability led to some range expansions and contractions; but, overall it had a small impact on the majority of species. Our results provide a baseline for comparison with studies of range changes during the Industrial period, demonstrating that contemporary rates of range loss exceed the magnitude of range changes seen over many thousands of years prior to the Industrial period by an alarming extent.
An Exploration of Current and Perspective Semen Analysis and Sperm Selection for Livestock Artificial Insemination
Authors: Zuidema Dalen , Kerns Karl , Sutovsky Peter
Published: December 2021

Artificial insemination of livestock has been a staple technology for producers worldwide for over sixty years. This reproductive technology has allowed for the rapid improvement of livestock genetics, most notably in dairy cattle and pigs. This field has experienced continuous improvements over the last six decades. Though much work has been carried out to improve the efficiency of AI, there are still many areas which continue to experience improvement, including semen analysis procedures, sperm selection techniques, sperm sexing technologies, and semen storage methods. Additionally, the use of AI continues to grow in beef cattle, horses, and small ruminants as the technology continues to become more efficient and yield higher pregnancy rates. In this review, AI trends in the various livestock species as well as cutting edge improvements in the aforementioned areas will be discussed at length. Future work will continue to refine the protocols which are used for AI and continue to increase pregnancy rates within all livestock species.
The Discontinuous Elevational Distribution of an Ungulate at the Regional Scale: Implications for Speciation and Conservation
Authors: Tan Kun , Li De-Pin , Li Na , Fang Yi-Hao , Li Yan-Peng , Xiao Wen
Published: December 2021

The elevational range where montane species live is a key factor of spatial niche partitioning, because the limits of such ranges are influenced by interspecies interaction, abiotic stress, and dispersal barriers. At the regional scale, unimodal distributions of single species along the elevation gradient have often been reported, while discontinuous patterns, such as bimodal distributions, and potential ecological implications have been rarely discussed. Here, we used extensive camera trap records to reveal the elevation distribution of Himalaya blue sheep (Pseudois nayaur) and its co-existence with other ground animal communities along a slope of Baima Snow Mountain, southwest China. The results show that Himalaya blue sheep exhibited a distinctive bimodal distribution along the elevation gradient contrasting the unimodal distributions found for the other ungulates in Baima snow mountain. A first distributional peak was represented by a population habituating in scree habitat around 4100 m, and a second peak was found in the dry-hot valley around 2600 m. The two distinct populations co-existed with disparate animal communities and these assemblages were similar both in the dry and rainy seasons. The extremely low abundance of blue sheep observed in the densely forested belt at mid-elevation indicates that vegetation rather than temperature is responsible for such segregation. The low-elevation population relied highly on Opuntia ficus-indica, an invasive cactus species that colonized the region six hundred years ago, as food resource. Being the only animal that developed a strategy to feed on this spiky plant, we suggest invasive species may have formed new foraging niche to support blue sheep population in lower elevation hot-dry river valleys, resulting in the geographic separation from the original population and a potential morphological differentiation, as recorded. These findings emphasize the important conservation values of role of ecological functions to identify different taxa, and conservation values of apparent similar species of different ecological functions.
Assessment of the Effectiveness of a Portable NIRS Instrument in Controlling the Mixer Wagon Tuning and Ration Management
Authors: Serva Lorenzo , Magrin Luisa , Marchesini Giorgio , Andrighetto Igino
Published: December 2021

The adoption of the mixer wagon and total mixed ration aimed to decrease dysmetabolic diseases and improve feed efficiency in dairy cows. Differences between theoretical and eaten diets are imputable to errors in diet preparation or cow feed sorting. We proposed a method to measure the chemical composition and particle size distribution of the ration and determined its peNDF content through a portable Near Infra-Red spectrophotometer that allowed the calculation of two indexes: the homogeneity and the sorting indexes. In a cohort of 19 Italian Holstein breeding farms, we studied the correlation of these indexes with the mixer wagon settings. Determination coefficients in the validation (Rv2) for dry matter, crude protein, aNDF, and starch were 0.91, 0.54, 0.86, and 0.67, respectively. The ration fractions (%, w/w of wet weight) retained by the 3.8 and 1.8 mm sieves, and the bottom showed Rv2 of 0.46, 0.49, and 0.53, respectively. The homogeneity index regressed negatively with the mixer wagon load fullness (R2 = 0.374). The homogeneity-binary classification showed an odds ratio of 1.72 for dry matter and 0.39 for aNDF (p < 0.05). The sorting-binary classification showed an odds ratio of 2.54 for aNDF (p < 0.05). The studied farms showed low peNDF values (median = 17.9%).
Pathogenesis of Velogenic Genotype VII.1.1 Newcastle Disease Virus Isolated from Chicken in Egypt via Different Inoculation Routes: Molecular, Histopathological, and Immunohistochemical Study
Authors: EL-Morshidy Yassmin , Abdo Walied , Elmahallawy Ehab Kotb , Abd EL-Dayem Ghada Allam , El-Sawak Ahmed , El-Habashi Nagwan , Mosad Samah M. , Lokman Maha S. , Albrakati Ashraf , Abou Asa Samah
Published: December 2021

Newcastle disease virus (NDV) remains a constant threat to the poultry industry. There is scarce information concerning the pathogenicity and genetic characteristics of the circulating velogenic Newcastle disease virus (NDV) in Egypt. In the present work, NDV was screened from tracheal swabs collected from several broiler chicken farms (N = 12) in Dakahlia Governorate, Egypt. Real-time reverse transcriptase polymerase chain reaction (RRT-PCR) was used for screening of velogenic and mesogenic NDV strains through targeting F gene fragment amplification, followed by sequencing of the resulting PCR products. The identified strain, namely, NDV-CH-EGYPT-F42-DAKAHLIA-2019, was isolated and titrated in the allantoic cavity of 10 day old specific pathogen-free (SPF) embryonated chicken eggs (ECEs), and then their virulence was determined by mean death time (MDT) and intracerebral pathogenicity index (ICPI). The pathogenicity of the identified velogenic NDV strain was also assessed in 28 day old chickens using different inoculation routes as follows: intraocular, choanal slit, intranasal routes, and a combination of both intranasal and intraocular routes. In addition, sera were collected 5 and 10 days post inoculation (pi) for the detection of NDV antibodies by hemagglutination inhibition test (HI), and tissue samples from different organs were collected for histopathological and immunohistochemical examination. A series of different clinical signs and postmortem lesions were recorded with the various routes. Interestingly, histopathology and immunohistochemistry for NDV nucleoprotein displayed widespread systemic distribution. The intensity of viral nucleoprotein immunolabeling was detected within different cells including the epithelial and endothelium lining, as well as macrophages. The onset, distribution, and severity of the observed lesions were remarkably different between various inoculation routes. Collectively, a time-course comparative pathogenesis study of NDV infection demonstrated the role of different routes in the pathogenicity of NDV. The intranasal challenge was associated with a prominent increase in NDV lesions, whereas the choanal slit route was the route least accompanied by severe NDV pathological findings. Clearly, the present findings might be helpful for implementation of proper vaccination strategies against NDV.