bluuebunny/crossref_metadata_2025 huggingface dataset:
Variability of Isotope Composition of Precipitation in the Southeastern Tibetan Plateau from the Synoptic to Seasonal Time Scale
Authors: Shi Xiaoyi , Risi Camille , Pu Tao , Lacour Jean‐Lionel , Kong Yanlong , Wang Ke , He Yuanqing , Xia Dunsheng
Published: March 2020

Daily precipitation samples were collected at four sites in Mount Yulong and Mount Meili regions of southeastern Tibetan Plateau and analyzed for isotopic composition. Combined with water vapor isotopic composition derived from satellites data (Infrared Atmospheric Sounding Interferometer, Tropospheric Emission Spectrometer, and Greenhouse gases Observing Satellite), the factors controlling the variability in the isotopic composition of precipitation are investigated at the synoptic, intraseasonal, and seasonal time scales. At the seasonal scale, the isotope composition in precipitation is controlled by processes along air mass trajectories affecting the water vapor at the large scale (>200 km), especially upstream deep convection and air mass origin, and by local processes transforming the large‐scale water vapor isotopic composition into the precipitation composition, especially rain evaporation and local circulation. At the intraseasonal and synoptic scales, the isotope composition in precipitation is mainly controlled by these local processes. The shorter the time scale of isotopic variations, the smaller the spatial imprint of these variations. The fact that different factors control the isotopic variability at different time scales calls for caution when applying relationships observed at these time scales to interpret isotopic variations at paleoclimatic time scales. While general circulation models successfully capture the isotopic variability and its controlling factors at the seasonal scale, it fails to simulate them at shorter time scales, because it fails to simulate the local processes.
Observation Constrained Aromatic Emissions in Shanghai, China
Authors: Wang Hongli , Yan Rusha , Xu Tingting , Wang Yuhang , Wang Qian , Zhang Tianqi , An Jingyu , Huang Cheng , Gao Yaqin , Gao Yang , Li Xiang , Yu Chao , Jing Shengao , Qiao Liping , Lou Shengrong , Tao Shikang , Li Yingjie
Published: March 2020

Aromatics in the atmosphere are a large contributor to ozone and secondary organic aerosol formation and have an adverse impact on human health. Observation‐based emissions are urgently needed for air quality management and decision making due to the large uncertainties in the emissions inventories. Atmospheric aromatics were continuously observed at one urban site in Shanghai of China in 2015, which were compared with the simulations of the Community Multiscale Air Quality (CMAQ) model. Large differences were found in the temporal variations between the model and measurements, corroborating with previous studies that the current bottom‐up emission inventories are highly biased. We corrected the aromatic emissions biases of the emission inventories using the observations with the CMAQ simulations, with the assumption that the response relationship of the emissions input and aromatic concentrations was reasonable on a monthly basis in CMAQ simulations, suggesting that the results are dependent on the model performance. The resulting aromatic emissions exhibited clear monthly variations, increasing from 5.5 ± 2.1 Gg month−1 in February to 17.4 ± 7.7 Gg month−1 in July, being different from the flat monthly pattern in the current bottom‐up emissions inventory. Toluene, xylenes, and ethylbenzene dominated aromatic emissions, accounting for ~74% on average but with considerable monthly variations, which was different from the nearly uniform value of 77% throughout the whole year in the emissions inventory. These highly temporally resolved and speciated in situ aromatics measurements provide observation‐based constraints on aromatic emissions, which cannot be obtained from satellite measurements. This study proposes a top‐down emission estimation method constrained by ambient measurements.
Quantifying Provenance and Transport Pathways of Holocene Sediments From the Northwestern Greenland Margin
Authors: Caron Myriam , Montero‐Serrano Jean‐Carlos , St‐Onge Guillaume , Rochon André
Published: March 2020

The mineralogical and geochemical compositions of three sediment cores from the northwestern Greenland continental margin (AMD14‐204 and AMD14‐210) and Kane Basin (AMD14‐Kane2B) were investigated using quantitative X‐ray diffraction and energy‐dispersive X‐ray fluorescence in order to document the impact of ice‐ocean interactions on the sediment provenance and transport pathways during the Holocene. Unmixing of the sediment composition and ratios such as quartz/clays and K/Fe indicate that detrital sediments in cores from the northwest Greenland margin are derived mainly from Prøven granite and reworked Archean gneiss, whereas sediments from Kane Basin are derived mainly from detrital carbonate (Ellesmere Island) and Proterozoic gneiss (Humboldt Glacier). Mineralogical and geochemical signatures also reveal that changes in detrital sediment provenance and transport in the region are strongly interconnected to regional ice stream dynamics, especially during the early Holocene with strong meltwater discharge from the Greenland Ice Sheet associated with the end of deglaciation. With the establishment of milder conditions during the mid‐Holocene and reduced glacial activity once ice sheets retreated inland, sediment inputs via ocean currents became more effective. Thus, detrital proxies in core AMD14‐204, located in the Upernavik cross‐shelf trough, support the hypothesis of an intensification of the West Greenland Current influence after 7.7 cal ka BP, which eventually affected the regional sediment dynamic by a greater contribution from basalt to the sediment supply. Finally, our results suggest that the interactions between climate, glacial dynamics, and surface ocean circulation controlled the paleoenvironmental changes observed in the three cores.
Joint international consensus statement for ending stigma of obesity
Authors: Rubino Francesco , Puhl Rebecca M. , Cummings David E. , Eckel Robert H. , Ryan Donna H. , Mechanick Jeffrey I. , Nadglowski Joe , Ramos Salas Ximena , Schauer Phillip R. , Twenefour Douglas , Apovian Caroline M. , Aronne Louis J. , Batterham Rachel L. , Berthoud Hans-Rudolph , Boza Camilo , Busetto Luca , Dicker Dror , De Groot Mary , Eisenberg Daniel , Flint Stuart W. , Huang Terry T. , Kaplan Lee M. , Kirwan John P. , Korner Judith , Kyle Ted K. , Laferrère Blandine , le Roux Carel W. , McIver LaShawn , Mingrone Geltrude , Nece Patricia , Reid Tirissa J. , Rogers Ann M. , Rosenbaum Michael , Seeley Randy J. , Torres Antonio J. , Dixon John B.
Published: March 2020

People with obesity commonly face a pervasive, resilient form of social stigma. They are often subject to discrimination in the workplace as well as in educational and healthcare settings. Research indicates that weight stigma can cause physical and psychological harm, and that affected individuals are less likely to receive adequate care. For these reasons, weight stigma damages health, undermines human and social rights, and is unacceptable in modern societies. To inform healthcare professionals, policymakers, and the public about this issue, a multidisciplinary group of international experts, including representatives of scientific organizations, reviewed available evidence on the causes and harms of weight stigma and, using a modified Delphi process, developed a joint consensus statement with recommendations to eliminate weight bias. Academic institutions, professional organizations, media, public-health authorities, and governments should encourage education about weight stigma to facilitate a new public narrative about obesity, coherent with modern scientific knowledge.
Evaluation of Rationally Designed Label-free Stem-loop DNA Probe Opening in the Presence of miR-21 by Circular Dichroism and Fluorescence Techniques
Authors: Farahani Nasrin , Behmanesh Mehrdad , Ranjbar Bijan
Published: March 2020

The characteristic features of stem-loop structured probes make them robust tools to detect targets with high sensitivity and selectivity. The basis of the hairpin based sensors operation is a conformational change that occurs upon hybridization of target with stem-loop probe. The design of the stem-loop probe has an important role in target recognition. Therefore, we designed a label-free stem loop probe for targeting miR-21 as a cancer biomarker investigated by web-based tools; its thermodynamic parameters obtained by thermal UV spectroscopy. The efficiency of stem-loop structure opening in the presence of target and non-target sequences was evaluated by fluorescence spectroscopy and circular dichroism spectro-polarimetry. The results showed that the target sequence opens the structure of hairpin efficiently in comparison to non-target sequences. To optimize the stem-loop hybridization to its target, the buffer ionic strength was changed by adding different concentrations of NaCl, KCl and MgCl2. It was shown that buffering conditions have a significant role in loop structure opening and its optimization, led to an increase in sensitivity detection and have improved LOD from 60 pM to 45 pM.
Self-assembly of Pseudo-Dipolar Nanoparticles at Low Densities and Strong Coupling
Authors: Brito Mariano E. , Carignano Marcelo A. , Marconi Verónica I.
Published: March 2020

Nanocolloids having directional interactions are highly relevant for designing new self-assembled materials easy to control. In this article we report stochastic dynamics simulations of finite-size pseudo-dipolar colloids immersed in an implicit dielectric solvent using a realistic continuous description of the quasi-hard Coulombic interaction. We investigate structural and dynamical properties near the low-temperature and highly-diluted limits. This system self-assembles in a rich variety of string-like configurations, depicting three clearly distinguishable regimes with decreasing temperature: fluid, composed by isolated colloids; string-fluid, a gas of short string-like clusters; and string-gel, a percolated network. By structural characterization using radial distribution functions and cluster properties, we calculate the state diagram, verifying the presence of string-fluid regime. Regarding the string-gel regime, we show that the antiparallel alignment of the network chains arises as a novel self-assembly mechanism when the characteristic interaction energy exceeds the thermal energy in two orders of magnitude, ud/kBT ≈ 100. This is associated to relevant structural modifications in the network connectivity and porosity. Furthermore, our results give insights about the dynamically-arrested nature of the string-gel regime, where we show that the slow relaxation takes place in minuscule energy steps that reflect local rearrangements of the network.
Iron redox pathway revealed in ferritin via electron transfer analysis
Authors: Chen Peng , De Meulenaere Evelien , Deheyn Dimitri D. , Bandaru Prabhakar R.
Published: March 2020

Ferritin protein is involved in biological tissues in the storage and management of iron - an essential micro-nutrient in the majority of living systems. While there are extensive studies on iron-loaded ferritin, its functionality in iron delivery is not completely clear. Here, for the first time, differential pulse voltammetry (DPV) has been successfully adapted to address the challenge of resolving a cascade of fast and co-occurring redox steps in enzymatic systems such as ferritin. Using DPV, comparative analysis of ferritins from two evolutionary-distant organisms has allowed us to propose a stepwise resolution for the complex mix of concurrent redox steps that is inherent to ferritins and to fine-tune the structure-function relationship of each redox step. Indeed, the cyclic conversion between Fe3+ and Fe2+ as well as the different oxidative steps of the various ferroxidase centers already known in ferritins were successfully discriminated, bringing new evidence that both the 3-fold and 4-fold channels can be functional in ferritin.
BCAP31, a cancer/testis antigen-like protein, can act as a probe for non-small-cell lung cancer metastasis
Authors: Wang Jing , Jiang Dongbo , Li Zichao , Yang Shuya , Zhou Jiayi , Zhang Guanwen , Zhang Zixin , Sun Yuanjie , Zhang Zhipei , Li Xiaofei , Tao Liang , Shi Jingqi , Lu Yuchen , Zheng Lianhe , Song Chaojun , Yang Kun
Published: March 2020

Non-small-cell lung cancer (NSCLC) represents most of lung cancers, is often diagnosed at an advanced metastatic stage. Therefore, exploring the mechanisms underlying metastasis is key to understanding the development of NSCLC. The expression of B cell receptor-associated protein 31 (BCAP31), calreticulin, glucose-regulated protein 78, and glucose-regulated protein 94 were analyzed using immunohistochemical staining of 360 NSCLC patients. It resulted that the high-level expression of the four proteins, but particularly BCAP31, predicted inferior overall survival. What’s more, BCAP31 was closely associated with histological grade and p53 status, which was verified by seven cohorts of NSCLC transcript microarray datasets. Then, three NSCLC cell lines were transfected to observe behavior changes BCAP31 caused, we found the fluctuation of BCAP31 significantly influenced the migration, invasion of NSCLC cells. To identify the pathway utilized by BCAP31, Gene Set Enrichment Analysis was firstly performed, showing Akt/m-TOR/p70S6K pathway was the significant one, which was verified by immunofluorescence, kinase phosphorylation and cellular behavioral observations. Finally, the data of label-free mass spectroscopy implied that BCAP31 plays a role in a fundamental biological process. This study provides the first demonstration of BCAP31 as a novel prognostic factor related to metastasis and suggests a new therapeutic strategy for NSCLC.
Effect of osmolytes on in-vitro aggregation properties of peptides derived from TGFBIp
Authors: Venkatraman Anandalakshmi , Murugan Elavazhagan , Lin Shu Jun , Peh Gary Swee Lim , Rajamani Lakshminarayanan , Mehta Jodhbir S.
Published: March 2020

Protein aggregation has been one of the leading triggers of various disease conditions, such as Alzheimer’s, Parkinson’s and other amyloidosis. TGFBI-associated corneal dystrophies are protein aggregation disorders in which the mutant TGFBIp aggregates and accumulates in the cornea, leading to a reduction in visual acuity and blindness in severe cases. Currently, the only therapy available is invasive and there is a known recurrence after surgery. In this study, we tested the inhibitory and amyloid dissociation properties of four osmolytes in an in-vitroTGFBI peptide aggregation model. The 23-amino acid long peptide (TGFBIp 611–633 with the mutation c.623 G>R) from the 4th FAS-1 domain of TGFBIp that rapidly forms amyloid fibrils was used in the study. Several biophysical methods like Thioflavin T (ThT) fluorescence, Circular Dichroism (CD), fluorescence microscopy and Transmission electron microscopy (TEM) were used to study the inhibitory and amyloid disaggregation properties of the four osmolytes (Betaine, Raffinose, Sarcosine, and Taurine). The osmolytes were effective in both inhibiting and disaggregating the amyloid fibrils derived from TGFBIp 611–633 c.623 G>R peptide. The osmolytes did not have an adverse toxic effect on cultured human corneal fibroblast cells and could potentially be a useful therapeutic strategy for patients with TGFBIp corneal dystrophies.
Evolutionary Game Simulation of Knowledge Transfer in Industry-University-Research Cooperative Innovation Network under Different Network Scales
Authors: Cao Xia , Li Chuanyun
Published: March 2020

This paper takes the industry-university-research cooperation innovation network constructed by the weighted evolutionary BBV model as the research object, which is based on bipartite graph and evolutionary game theory, and constructing the game model of knowledge transfer in the industry-university-research cooperation innovation network, by using the simulation analysis method and analyzing the evolution law of knowledge transfer in the industry-university-research cooperation innovation network under different network scales, three scenarios, the knowledge transfer coefficient and the knowledge reorganization coefficient. The results show that the increase of network scale reduces the speed of knowledge transfer in the network, and the greater the average cooperation intensity of the nodes, the higher the evolution depth of knowledge transfer. Compared with university-research institutes, the evolution depth of knowledge transfer in enterprises is higher, and with the increase of network scale, the gap between the evolution depth of knowledge transfer between them is gradually increasing. Only when reward, punishment and synergistic innovation benefits are higher than the cost of knowledge transfer that can promote the benign evolution of industry-university-research cooperation innovation networks. Only when the knowledge transfer coefficient and the knowledge reorganization coefficient exceed a certain threshold will knowledge transfer behavior emerge in the network. With the increase of the knowledge transfer coefficient and the knowledge reorganization coefficient, the knowledge transfer evolutionary depth of the average cooperation intensity of all kinds of nodes is gradually deepening.
Effective Schottky barrier lowering of NiGe/p-Ge(100) using Terbium interlayer structure for high performance p-type MOSFETs
Authors: Eadi Sunil Babu , Lee Jeong Chan , Song Hyeong-Sub , Oh Jungwoo , Lee Ga-Won , Lee Hi-Deok
Published: March 2020

Ultra-low contact resistance at the interface between NiGe and p-Ge, i.e., NiGe/p-Ge was achieved by introducing terbium (Tb) as an interlayer in forming NiGe using Tb/Ni/TiN structure. The contact resistance value obtained using the circular transmission line model for an 8-nm thick Tb interlayer sample was 7.21 × 10−8 Ω·cm2, which is two orders of magnitude less than that of reference sample (without the Tb interlayer) of 7.36 × 10−6 Ω·cm2. The current–voltage characteristics were studied at a temperature range of −110 ~ 25 °C to determine the effective Schottky barrier height (eSBH). An eSBH of 0.016 eV was obtained for the 8-nm thick Tb interlayer. Various Tb interlayer thicknesses were selected to study their effect on the contact resistance. The Tb interlayer surface and structural properties were characterized using FESEM, XRD, XPS, TEM, and SIMS analyses.
Author Correction: Isolation and identification of two pairs of cytotoxic diterpene tautomers and their tautomerization mechanisms
Authors: Dai Li-Ping , Li Xiao-Fei , Feng Qing-Mei , Zhang Ling-Xia , Liu Qiu-Yan , Xu Er-Ping , Wu Hong , Wang Zhi-Min
Published: March 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Therapeutic normal IgG intravenous immunoglobulin activates Wnt-β-catenin pathway in dendritic cells
Authors: Karnam Anupama , Rambabu Naresh , Das Mrinmoy , Bou-Jaoudeh Melissa , Delignat Sandrine , Käsermann Fabian , Lacroix-Desmazes Sébastien , Kaveri Srini V. , Bayry Jagadeesh
Published: March 2020

Therapeutic normal IgG intravenous immunoglobulin (IVIG) is a well-established first-line immunotherapy for many autoimmune and inflammatory diseases. Though several mechanisms have been proposed for the anti-inflammatory actions of IVIG, associated signaling pathways are not well studied. As β-catenin, the central component of the canonical Wnt pathway, plays an important role in imparting tolerogenic properties to dendritic cells (DCs) and in reducing inflammation, we explored whether IVIG induces the β-catenin pathway to exert anti-inflammatory effects. We show that IVIG in an IgG-sialylation independent manner activates β-catenin in human DCs along with upregulation of Wnt5a secretion. Mechanistically, β-catenin activation by IVIG requires intact IgG and LRP5/6 co-receptors, but FcγRIIA and Syk are not implicated. Despite induction of β-catenin, this pathway is dispensable for anti-inflammatory actions of IVIG in vitro and for mediating the protection against experimental autoimmune encephalomyelitis in vivo in mice, and reciprocal regulation of effector Th17/Th1 and regulatory T cells.
Synthesis of corrugated surface AgNWs and their applications in surface enhanced Raman spectroscopy
Authors: Fahad Shah , Yu Haojie , Wang Li , Wang Yang , Elshaarani Tarig , Amin Bilal Ul , Naveed Kaleem-ur-Rahman , Khan Rizwan Ullah , Mehmood Sahid , Haq Fazal , Ni Zheping , Usman Muhammad
Published: March 2020

Among metals, AgNWs are considered to be excellent materials for use in surface enhancement Raman spectroscopic (SERS) sensing due to their superior electrical properties, strong electromagnetic field generation and strong enhancement intensity.
Discovery of a novel kinase hinge binder fragment by dynamic undocking
Authors: Rachman Moira , Bajusz Dávid , Hetényi Anasztázia , Scarpino Andrea , Merő Balázs , Egyed Attila , Buday László , Barril Xavier , Keserű György M.
Published: March 2020

A virtual screening workflow for fragment-sized kinase inhibitors is presented, along with a newly identified and validated hinge binder fragment.
Imaging and therapeutic applications of Zn(ii)-cryptolepine–curcumin molecular probes in cell apoptosis detection and photodynamic therapy
Authors: Qin Qi-Pin , Wei Zu-Zhuang , Wang Zhen-Feng , Huang Xiao-Ling , Tan Ming-Xiong , Zou Hua-Hong , Liang Hong
Published: March 2020

The probes could synergistically promote mitochondrion-mediated apoptosis and enhance tumor therapeutic effects during photodynamic therapy.
Low-temperature synthesis of 2D anisotropic MoTe2 using a high-pressure soft sputtering technique
Authors: Yumigeta Kentaro , Kopas Cameron , Blei Mark , Hajra Debarati , Shen Yuxia , Trivedi Dipesh , Kolari Pranvera , Newman Nathan , Tongay Sefaattin
Published: March 2020

High-pressure soft sputtering: large area 1T′ phase MoTe2 thin films were grown at temperatures as low as 300 °C.
Bimetallic and postsynthetically alloyed PtCu nanostructures with tunable reactivity for the methanol oxidation reaction
Authors: Xiang Haiyan , Zheng Yueshao , Sun Yue , Guo Tingting , Zhang Pei , Li Wei , Kong Shiwei , Ouzounian Miray , Chen Hong , Li Huimin , Hu Travis Shihao , Yu Gang , Feng Yexin , Liu Song
Published: March 2020

Small Pt nanoparticles were deposited on metallic Cu nanowires with tunable compositions and a further annealing process provided alloy PtCu samples with tunable crystal structures.
Fabrication of solvent transfer-induced phase separation bijels with mixtures of hydrophilic and hydrophobic nanoparticles
Authors: Di Vitantonio Giuseppe , Lee Daeyeon , Stebe Kathleen J.
Published: March 2020

Solvent transfer-induced phase separation bijels with oils of different polarity are fabricated by using a mixture of hydrophilic and hydrophobic silica nanoparticles, further expanding their potential applications in separation and catalysis.
How an unusual chemosensory system forms arrays on the bacterial nucleoid
Authors: Mauriello Emilia M.F.
Published: March 2020

Chemosensory systems are signaling pathways elegantly organized in hexagonal arrays that confer unique functional features to these systems such as signal amplification. Chemosensory arrays adopt different subcellular localizations from one bacterial species to another, yet keeping their supramolecular organization unmodified. In the gliding bacterium Myxococcus xanthus, a cytoplasmic chemosensory system, Frz, forms multiple clusters on the nucleoid through the direct binding of the FrzCD receptor to DNA. A small CheW-like protein, FrzB, might be responsible for the formation of multiple (instead of just one) Frz arrays. In this review, we summarize what is known on Frz array formation on the bacterial chromosome and discuss hypotheses on how FrzB might contribute to the nucleation of multiple clusters. Finally, we will propose some possible biological explanations for this type of localization pattern.
Mesophyll conductance: the leaf corridors for photosynthesis
Authors: Gago Jorge , Daloso Danilo M. , Carriquí Marc , Nadal Miquel , Morales Melanie , Araújo Wagner L. , Nunes-Nesi Adriano , Flexas Jaume
Published: March 2020

Besides stomata, the photosynthetic CO2 pathway also involves the transport of CO2 from the sub-stomatal air spaces inside to the carboxylation sites in the chloroplast stroma, where Rubisco is located. This pathway is far to be a simple and direct way, formed by series of consecutive barriers that the CO2 should cross to be finally assimilated in photosynthesis, known as the mesophyll conductance (gm). Therefore, the gm reflects the pathway through different air, water and biophysical barriers within the leaf tissues and cell structures. Currently, it is known that gm can impose the same level of limitation (or even higher depending of the conditions) to photosynthesis than the wider known stomata or biochemistry. In this mini-review, we are focused on each of the gm determinants to summarize the current knowledge on the mechanisms driving gm from anatomical to metabolic and biochemical perspectives. Special attention deserve the latest studies demonstrating the importance of the molecular mechanisms driving anatomical traits as cell wall and the chloroplast surface exposed to the mesophyll airspaces (Sc/S) that significantly constrain gm. However, even considering these recent discoveries, still is poorly understood the mechanisms about signaling pathways linking the environment a/biotic stressors with gm responses. Thus, considering the main role of gm as a major driver of the CO2 availability at the carboxylation sites, future studies into these aspects will help us to understand photosynthesis responses in a global change framework.
Research on the operational regional coverage of satellite and spacecraft tracking and controlling
Authors: Qi Lihua , Xing Dongqiu , Wang Rui , Cui Jingna
Published: March 2020

In view of the problem of building ground stations for tracking and controlling of satellites and spacecraft, considering the fixed angle between the orbit of the satellite or spacecraft and the equatorial surface of the earth, and the difference of longitude between the two circles in succession of the satellite or spacecraft caused by the rotation of the earth, the operation area of the satellite or spacecraft was calculated by using the method of spherical projection of satellite orbit rotation, taking the earth as the reference system. The minimum number of ground stations needed for satellite tracking and controlling was calculated in three cases, by using the mathematical model of sphere ring area and honeycomb coverage. This model was validated by the launch and operation data of Shenzhou 7.
Research and realization of RTI data transmission method based on attribute reflection
Authors: Wang Long , Fang Juan , Xiao Qiang , Cai Liang
Published: March 2020

In order to solve the error of simulation result because of data loss in VR-Link traditional simulation framework, in this paper data transfer mechanism of instance attribute on VR-Link object class is researched in detail. Registration method of call-back function is given, and the key codes of relevant steps are published. The problem of data loss is solved by the call-back function of VR-Link.
Packed malware variants detection using deep belief networks
Authors: Zhang Zhigang , Chang Chaowen , Han Peisheng , Zhang Hongtao
Published: March 2020

Malware is one of the most serious network security threats. To detect unknown variants of malware, many researches have proposed various methods of malware detection based on machine learning in recent years. However, modern malware is often protected by software packers, obfuscation, and other technologies, which bring challenges to malware analysis and detection. In this paper, we propose a system call based malware detection technology. By comparing malware and benign software in a sandbox environment, a sensitive system call context is extracted based on information gain, which reduces obfuscation caused by a normal system call. By using the deep belief network, we train a malware detection model with sensitive system call context to improve the detection accuracy.
A three-tier scheme for sybil attack detection in heterogeneous IWSN
Authors: Wang Hui
Published: March 2020

Industrial wireless sensor network is a new application of wireless sensor network in the field of industry in recent years. However, IWSN may be subject to different attacks and security risks, among which the Sybil attack is the most harmful type of base attack. According to the characteristics of wireless sensor networks in industrial environment, a new three-tier detection scheme is proposed. In the first-level, all common nodes and Sybil nodes were detected by RSSI-based quadratic difference method. In the second layer, the residual energy-based method is used to continue the detection of the nodes that have been detected in the first-level. The detection of first and second-level high-energy nodes is finally completed by the base station. The simulation results show that our proposed scheme significantly improves network lifetime and effectively improve the detection rate of Sybil nodes.
Ranking chat logs for crime investigation
Authors: Xiao Wen
Published: March 2020

Aiming at the needs of criminal investigators to quickly find chat logs related to crime case, a ranking method for chat texts has been proposed. First, query keywords were used to search chat texts, and the feedback texts were divided into relevant texts and irrelevant texts with manual annotation, then non-negative matrix factorization (NMF) was utilized to obtain the implicit semantic relationship of chat texts, finally chat logs could be ranked based on the scores calculated by similarity. Experiments show that the method proposed in this paper can quickly retrieve and get the messages of interest in a lot of chat logs, which can facilitate crime investigation.
Black-box approach for software testing based on fat-property
Authors: TanLi Mengqing , Jiang Yan , Wang Xiang , Peng Rushu
Published: March 2020

After a useful and summarized procedure of software testing is put forward based software engineering view, this paper proposed a definition of fat-property according to software testing activity in product quality monitoring software. Based on fat-property, black-box testing approach is deeply investigated. In unit testing, equivalence partitioning should include two aspects: data inputting type and function operating type. And a key point of black-box testing is design of boundary/sub- boundary testing case for data inputting type. In integration testing, Sandwich mode should be applied to improve coverage. In validation testing, keynote function and non- keynote function may be tested respectively to accelerate speed of testing and assure coverage of function. System testing based on black-box according to actual usage of software product is very important, and it will determine the quality level of software product.
Research on mobile cloud service model based on WBS
Authors: Zhu Manli , Wang Suzhen , Zhang Lu , Zhang Yanpiao
Published: March 2020

The construction of mobile cloud service platform is innovative complex project. This paper analyzed service innovation behavior based on the four-dimensional model of service innovation, and to study the implementation process of mobile cloud service platform for rural leisure tourism based on WBS method multi-dimensional description, to propose a rolling, flow-based work breakdown structure design idea. The research results show that by properly setting the WBS and monitoring points, it is possible to detect and prevent the deviation of the progress cost correlation in time and to ensure the quality of the platform. Research results can provide the basis for decision making by relevant industry managers.
A kind of multimode nonlinear algorithm for efficiency-improved course keeping of large tankers
Authors: Zhao Hongbiao , Zhang Xianku
Published: March 2020

In order to achieve efficient control of ship course keeping with low energy consumption, this paper introduces nonlinear feedback into fuzzy control and closed-loop gain shaping algorithm (CGSA). Taking the ship “New Triumph” as an example, the simulation results show that the multimode controller with non-linear feedback can not only respond to the steering instructions quickly, but also reduce the energy consumption by 32% to realize the course keeping efficiently and smoothly under the wind-wave model. Research shows that the introduction of nonlinear feedback term can optimize the control system, and its advantages of saving energy consumption are of great significance in practical engineering applications.
Research on healthy catering recommendation space
Authors: Deng Yongjie , Liu Yong , Tang Dongping
Published: March 2020

This paper conducts an in-depth study on the catering recommendation space based on different situations. By consulting the literature, visiting relevant experts, condensing the theoretical knowledge of TCM (Traditional Chinese Medicine) constitutional dietotherapy theory, it has extracted some key factors that can be effectively utilized in catering theory. The variable framework of the situational catering recommendation system is preliminarily constructed. Also, it has designed a mixed catering recommendation space that combines TCM Constitutional Theory and user situation, which not only meets individual preferences but also improves the users’ sub-health status. Finally, through the questionnaire survey, the importance of each attribute in the eyes of consumers has been recognized; then this essay provides a guidance for the recommendation ranking method in the design of the catering recommendation system after making the cross-analysis.
Shuffled frog leaping algorithm based on quantum rotation angle
Authors: Hu Bibo
Published: March 2020

In this paper, through the analysis of the artificial intelligence algorithm, shuffled frog leaping algorithm is effectively improved, and the position of the frog is determined by the quantum rotation angle, so as to improve the performance of the algorithm. Compared with the artificial bee colony algorithm and the shuffled frog leaping algorithm, the improved algorithm has a significant improvement in the convergence speed of the algorithm and the ability to jump out of the local area.
Ultrasonic guided wave detection of U-shaped pipeline
Authors: Zhu Longxiang , Kong Guangming , Zhang Haibing , Yu Xiangyang
Published: March 2020

The guided waves in the elbow was analyzed using semi- analytical finite element method, which was used to calculate the dispersion curves, along with the vibration deformation and energy flow density distribution of the elbow cross-section. The L(0,1) mode guided wave was used to detect different defects in the U-shaped pipeline in experiment. The average experimental velocity of L(0,1) mode in U-shaped pipeline was between the theoretical velocities of the straight pipe and the elbow, due to the different velocities in the two parts. The detection sensitivity difference of L(0,1) mode guided wave to defects in intrados and extrados of the elbow was analyzed, the experimental result showed that the reflected signal amplitude of defect in extrados was significantly larger than the defect in intrados, which was consistent with the energy flow density distribution in elbow cross-section.
Support vector machine filtering data aid on fatigue driving detection
Authors: LI Zuojin , Song Lei , Yang Qing , Chen Shengfu , Chen Liukui
Published: March 2020

This paper proposes an assumption that filtering out the confusing “awake” data from fatigue driving detection model promotes the accuracy of detection of “drowsy” status under real driving situation. Instead of focus on both “drowsy” and “awake” driving status, we set our first priority to alarm “drowsy” and temporarily ignore the accuracy of “awake” status recognition. The Support Vector Machine as a good classifier is employed for data filtering, provides more efficient training data and removes the data that may confuse the detection model. The results prove our assumption by 72% accuracy on “drowsy” recognition, which is higher than 38% recognition performed by detection without SVM filtering. In addition, the size of training samples after filtering for conducting detection model is extremely smaller than no filtering.
Two-degree-of-freedom manipulator path planning based on zeroing neural network
Authors: Li Yan , Liu Keping
Published: March 2020

In this paper, the shortest path problem of manipulator path planning is transformed into a linear programming problem, and solved by zeroing neural network (ZNN). Firstly, the method of constructing the zeroing neural dynamics is given, and the ZNN model is constructed for shortest path problem of manipulator. Then, the Lyapunov method is utilized to prove the stability of the ZNN model. Finally, the ZNN model is applied to the path planning of manipulator to generate an optimal planning path. The simulation results show that the proposed method can effectively realize the optimal path planning of the manipulator.
Fuzzy PD controller of UAV attitude under wind interference
Authors: Liu Boyan , Wang Yuanxin , Wen Jiaxin , Zhao Chaolun
Published: March 2020

In this paper, for the UAV attitude angle stabilization system under constant flat wind disturbance, the fuzzy adaptive PID control theory is used to establish the equation of wind disturbance attitude angle stability system. After mastering the control rate of the system, the fuzzy controller is designed by using matlab, and the attitude angle dynamic simulation analysis was carried out. The results show that under the interference of flat wind, the longitudinal attitude of the UAV is changed by interference, and the fuzzy adaptive PD is used to control the attitude angle of the aircraft, which has faster tracking performance, smaller adjustment time than the traditional PD control. Thereby achieving better maneuverability and less steady-state error. Therefore, the fuzzy adaptive PD can better control the attitude stability of the UAV, improve the wind resistance of the UAV, and ensure the flight is safe and reliable.
Design of parking management system for shared stroller based on RFID
Authors: Yu Lina
Published: March 2020

The development of information technology has led to the rapid development of sharing economy. Shared bike, Shared car and Shared stroller came into being. It not only brings convenience to citizens, but also has difficult management problems. This paper mainly proposes a solution to deal with the parking management of Shared stroller in shopping malls.The system is based on RFID technology. When the preset tag on the stroller is read successfully by the card reader,the stroller can be successfully locked and returned. Realize standardized management of Shared stroller in shopping malls.
Modular integrated thermal control system in scientific experimental express rack on space station
Authors: Guo Dongcai , Sheng Qiang , Guo Yu , Xue Jing , Wang Ze
Published: March 2020

As an important mission of space stations, space science experiment usually requires effective temperature control measures. Scientific experimental express rack (ER) is a general design for space science experiment. In some space scientific experiments, the temperature of local target element or surrounding exceed heat sink temperature range, effective heating and cooling measures are required. Thermoelectric cooler (TEC) has high reliability and low complexity, which is applicable for temperature control in low gravity conditions. In the ER, the entire surrounding is indirectly heated or cooled by the ambient air, local target element surface is heated or cooled by liquid, TEC is thermal competent for ER thermal control attributed to the low complexity and high reliability, which can enlarge the temperature range of air and liquid. In this paper, a modular integrated thermal control system (MITCS) is designed for a specific ER, which has liquid assembly (LA), TEC assembly (TECA), heat exchanger assembly (HXA) and air cycle assembly (ACA) to provide target surface cooling and heating, entire surrounding cooling and heating. The thermal performance of MITCS using TEC are analyzed, providing guides for the design of the scientific experimental ER and other thermal systems.
Design of photoacoustic microscope system based on labVIEW platform
Authors: Bai Yang , Zhang Chuncheng , Zeng Lvming , Liu Guodong
Published: March 2020

A photoacoustic microscope system based on virtual instrument development environment is presented, including ultrasonic sensor, digital oscilloscope, laser diode, personal calculation and other hardware platforms. and developed supporting software and image reconstruction algorithms. In the subcutaneous angiography experiment, the distribution characteristics of the ear blood vessels in mouse were completely reproduced perfectly, and the spatial resolution of the system can reach 14um. The system and method can potentially to develop into a non-invasive biological tissue structure and functional imaging technique.
Predication of life cycle cost of equipment base on unbiased grey Markov models
Authors: Chen Yonghong , Hu Ping , Zhang Dong
Published: March 2020

Life cycle cost(LCC) is an important content of equipment integrated logistics support. While the LCC includes the whole life cycle of equipment from development, production, service and maintenance to retirement, in order to effectively manage and control the LCC and better develop integrated logistics support, it is necessary to analyze and predict it. The unbiased grey markov model(UGMM) was introduced into the LCC prediction in the paper, in order to check model accuracy, the posterior difference method(PDM) was used, also the influence by the number of state intervals in UGMM on the prediction accuracy is analyzed and studied. The result indicate that UGMM can be used to predict the LCC, also have the highest prediction accuracy comparing with unbiased grey model and grey separating model, and in order to ensure the prediction accuracy, the state interval should be divided according to the number of sequence.
Data warehouse dimensional modeling for customer service business
Authors: Mu Songhe , Zhu Qing , Zhang Yue , An Yeteng
Published: March 2020

The daily traffic volume of the State Grid 95598 Customer Service Center exceeds 800,000. In order to manage and store these massive data, we must carefully handle it. The call from electric customers implement the business philosophy of “Quality service is the lifeline of electric power enterprise”, and carry out related data aggregation, processing, statistics, conversion and analysis based on data warehouse, and fully explore and analyze these with big data analysis technology. The potential value in the data guides the optimization of business processes and improves the service quality and efficiency of the business center.
Research on the melt behavior of rare-earth-rich iron minerals by direct reduction
Authors: Guo Wentao , Wang Zhi , Zhao Zengwu , Wang Wenfeng
Published: March 2020

The evolution of mineral phase structure during the reduction and melting separation of an rare earth (RE)-rich iron mineral (RER-IM) is investigated. The results show the iron oxides are reduced to their metallic iron or FeO at 1373 K. When reduction time is 180 min, the reduction degree is 84%. Both bastnaesite (RE(CO3)F) and monazite (REPO4) are transformed into Ca2RE8(SiO4)6O2 during carbothermic reduction at 1373 K. The mineral with a reduction degree of 84% is melt-separated in a graphite crucible at 1773 K for 20 min, the resulting slag contains 20.64% RE2O3, with RE existing in the form of Ca2RE8(SiO4)6O2. Moreover, P from the reduction of Ca3(PO4)2 dissolves in iron with a content ranging from 1.2 to 2.21%. The type of RE phase that occurs in the slag is related to the distribution of P between slag and iron. A low P content in the slag facilitates the formation of Ca2RE8(SiO4)6O2, but a high content in the slag favours Ca3RE2[(Si, P)O4]3F. Thus, it is confirmed that the RE phase structure is controlled by the distribution of P between slag and iron.
Yangambin and Epi-yangambin Isomers: New Purification Method from Ocotea fasciculata and First Cytotoxic Aspects Focusing on In Vivo Safety
Authors: Martins Júlia , Coelho Joana , Tadini Maraine Catarina , de Souza Rebeca Oliveira , Figueiredo Sonia Aparecida , Fonseca Maria José Vieira , de Albuquerque Nayara Cristina Perez , Lopes Norberto Peporine , Berretta Andresa , Marquele-Oliveira Franciane , de Oliveira Anderson Rodrigo Moraes
Published: March 2020

Ocotea fasciculata presents yangambin (YAN) and its isomer epi-yangambin (EPI-YAN) as major lignans, which are employed as the plant markers for quality control purposes and as potential pharmacological compounds. However, a gap between the pure isomers and safety and efficacy protocols is faced by the scientific community. In this context, this work aimed to report (i) a new and advantageous purifying process in a semi-preparative scale for YAN and EPI-YAN isolation from Ocotea fasciculata, and (ii) an in vitro cytotoxicity study to estimate, for the first time, the LD50 values of the isolated epimers, as well as the influence of albumin concentration in cell culture medium. The best condition for epimers isolation was achieved in normal-phase liquid chromatography. The lignan fraction (LF), previously obtained from the plant ethanolic extract, was purified yielding 17% and 29% of YAN and EPI-YAN, respectively. The in vitro study demonstrated that YAN and EPI-YAN were safe, and only at the highest concentration studied, a decrease on cell viability was observed. The estimated LD50 value was higher than 1612 mg/kg for both epimers. The LF, on the other hand, demonstrated an estimated LD50 of 422 mg/kg. Lignan cytotoxicity studies also evidenced that the higher cell viability was related to the higher concentration of fetal bovine serum as a source of albumin in medium. This is the first time the LD50 and safety of the isolated epimers were estimated, opening up great perspectives of success in in vivo studies.
Electrophilic Amination with Anthranils through Thioamide-Assisted Cobalt(III)-Catalyzed C(sp3)–H Activation
Authors: Li Jie , Liu Lei , Zhang Zhao , Wang Yucheng , Zhang Yan
Published: March 2020

Cobalt(III)-catalyzed electrophilic amination of inert C(sp3)–H bonds of weakly coordinating thioamides with readily accessible anthranil derivatives was accomplished under mild conditions, with good functional group tolerance, thus providing various amino aldehydes and amino ketones. Moreover, our protocol with the versatile [Cp*Co(MeCN)3][SbF6]2 features excellent atom-economy and oxidant-free conditions, and allows facile late-stage functionalization.
Co(II)-Catalyzed Desilylative Annulation of Benzamides and Acrylamides with Alkynylsilanes: Access to 3-Methyleneisoindolin-1-one and 5-Methylene-1H-pyrrol-2(5H)-one Derivatives
Authors: Lin Cong , Shen Liang , Wang Jingyu , Teng Qiuxun , Gao Fei , Liu Xiuhong
Published: March 2020

The cobalt-catalyzed desilylative annulation of C(sp2)–H bonds of benzamides and acrylamides with alkynylsilanes assisted by an 8-aminoquinolyl directing group is reported. A variety of benzamides and acrylamides were compatible in this protocol to construct various 3-methyleneisoindolin-1-one and 5-methylene-1H-pyrrol-2(5H)-one derivatives with Z-configuration selectivity in moderate to high yields.