bluuebunny/crossref_metadata_2025 huggingface dataset:
Association Between Late-Life Neuropsychiatric Symptoms and Cognitive Decline in Relation to White Matter Hyperintensities and Amyloid Burden
Authors: Chan Carol K. ,   and the BIOCARD Research Team, Pettigrew Corinne , Soldan Anja , Zhu Yuxin , Wang Mei-Cheng , Albert Marilyn , Rosenberg Paul B.
Published: February 2022

Background: Neuropsychiatric symptoms (NPS) among cognitively normal older adults are increasingly recognized as risk factors for cognitive decline and impairment. However, the underlying mechanisms remain unclear. Objective: To examine whether biomarkers of Alzheimer’s disease (amyloid burden) and cerebrovascular disease (white matter hyperintensity (WMH) volume) modify the association between NPS and cognitive decline among cognitively unimpaired older adults. Methods: Analyses included 193 cognitively unimpaired participants (M age = 70 years) from the BIOCARD study, including 148 with PET amyloid and WMH biomarker data. NPS were measured with Neuropsychiatric Inventory and Geriatric Depression Scale scores. Linear mixed effects models were used to examine the association between baseline NPS and longitudinal cognitive trajectories (M follow-up = 3.05 years), using separate models for global, episodic memory, and executive function cognitive composite scores. In a subset of individuals with biomarker data, we evaluated whether WMH or cortical amyloid burden modified the relationship between NPS and cognitive change (as indicated by the NPS×biomarker×time interactions). Results: Higher baseline NPS were associated with lower executive function scores, but not a faster rate of decline in executive function. NPS symptoms were unrelated to the global or episodic memory composite scores, and there was little evidence of a relationship between NPS symptoms and cognitive change over time. The associations between NPS and cognitive decline did not differ by amyloid or WMH burden, and NPS were unrelated to amyloid and WMH burden. Conclusion: These results suggest that the effect of neuropsychiatric symptoms on executive dysfunction may occur through mechanisms outside of amyloid and cerebrovascular disease.
Serum Amyloidogenic Nanoplaques and Cytokines in Alzheimer’s Disease: Pilot Study in a Small Naturalistic Memory Clinic Cohort
Authors: Aksnes Mari , Aass Hans Christian D. , Tiiman Ann , Terenius Lars , Bogdanović Nenad , Vukojević Vladana , Knapskog Anne-Brita
Published: February 2022

Background: Neuroinflammation is a central component of Alzheimer’s disease (AD) and correlates closely with amyloid pathology. Markers of inflammation such as cytokines, and amyloidogenic aggregates, so-called nanoplaques, are both promising biomarker candidates for AD. We have previously shown that there is a relationship between the levels of nanoplaques and cytokines in cerebrospinal fluid, but it is unknown whether this association extends to serum. Objective: Investigate in a naturalistic memory clinic cohort whether the associations between nanoplaques and cytokines in the cerebrospinal fluid extends to serum. Methods: We collected serum from 49 patients assessed for cognitive complaints at the Oslo University Hospital Memory Clinic (15 with clinical AD). We assessed the levels of serum nanoplaques with the novel Thioflavin-T fluorescence correlation spectroscopy (ThT-FCS) assay. Serum levels of nine cytokines (eotaxin-1, granulocyte colony-stimulating factor [G-CSF], interleukin [IL]-6, IL-7, IL-8, monocyte chemoattractant protein-1 (MCP-1), gamma induced protein 10 (IP-10), macrophage inflammatory protein [MIP]-1α, and MIP-1β) were quantified with a multiplex assay and read on a Luminex IS 200 instrument. Results: Serum nanoplaques were not increased in clinical AD patients compared to non-AD memory clinic patients and nanoplaques were not associated with any cytokines. The cytokines IL-8 and G-CSF were increased in patients with clinical AD compared to non-AD patients. Conclusion: In this small pilot study, serum nanoplaques were not associated with serum cytokines. Nanoplaque levels could not be used to separate clinical AD patients from non-AD patients in this unselected memory clinic cohort.
Notes on intuitionistic fuzzy soft ideals in BCK/BCI-algebras
Authors: Liu Nana , Wang Chang
Published: February 2022

In this paper, we show that the inappropriateness of Example 3.10 and the error of Theorem 4.7 in [M.Balamurugan, G.Balasubramanian, C.Ragavan. Intuitionistic Fuzzy Soft Ideals in BCK/BCI-algebras. Materials today: proceedings 16(2019)496-503.], then give a more perfect example and a counterexample respectively.
The Promise of Mendelian Randomization in Parkinson’s Disease: Has the Smoke Cleared Yet for Smoking and Parkinson’s Disease Risk?
Authors: Ritz Beate R. , Kusters Cynthia D.J.
Published: February 2022

This commentary discusses the strengths and limitations of utilizing the Mendelian randomization (MR) approach in Parkinson’s disease (PD) studies. Epidemiologists proposed to employ MR when genetic instruments are available that represent reliable proxies for modifiable lifelong exposures which elude easy measurement in studies of late onset diseases like PD. Here, we are using smoking as an example. The great promise of the MR approach is its resilience to confounding and reverse causation. Nevertheless, the approach has some drawbacks such as being liable to selection- and survival-bias, it makes some strong assumptions about the genetic instruments employed, and requires very large samples size. When interpreted carefully and put into the context of other studies that take both genetics and the environment into consideration, MR studies help us to not only ask interesting questions but also can support causal inference and provide novel insights.
Predicaments during a period of health emergency: Waiving patent protections or innovative public procurement? The example of advance purchase agreements (APA) for COVID-19 vaccines
Authors: Garrido Cuenca Nuria
Published: February 2022

BACKGROUND: The health emergency provoked by the worldwide pandemic requires immediate action to achieve the immunization of the population and to stop further contagion. The systems of public procurement needed to adapt in a very short time to reach agreements with the pharmaceutical industry. OBJECTIVE: Proposing options between the waiving of patent protections and innovative public procurement, principally the European Advance Purchase Agreements (APA). METHODS: A description of the actual situation and the necessary regulatory reforms. The sources are scientific articles, legislative compendiums and opinion pieces and the current press. RESULTS: The debate over the waiving of patent protections at this time is both misleading and ineffective due to the economic and legal problems involved. The path of the APA has proven to be very effective, although some deficits should be corrected, principally regarding questions of transparency and confidentiality. CONCLUSIONS: Among the possible options for the acquisition of the COVID-19 vaccine and its universal access, agreements and cooperation between States and innovative industry are desirable. One successful path is that of the advance purchase agreements utilized by the European Union, another could be that of voluntary licensing. We propose following these routes as opposed to the waiving of patent protections.
Collaboration among vocational rehabilitation and mental health leaders: Supporting the vocational success of transition-age youth with serious mental health conditions
Authors: Gatesy-Davis Anwyn , Koroloff Nancy , Marrone Joseph , Davis Maryann
Published: February 2022

BACKGROUND: The ability of vocational rehabilitation, adult mental health and child mental health service systems to collaborate regarding the employment and career development goals of transition-age youth has not been explored nor has attention been paid to strategies that would increase this collaboration. OBJECTIVE: This qualitative study asks leaders from these three systems to describe collaborative activities that support better vocational services for transition-age youth with serious mental health conditions and discuss barriers and facilitators to collaboration. METHODS: Qualitative interviews were conducted with 39 formal and informal leaders in vocational rehabilitation (n = 16), child mental health (n = 13), and adult mental health (n = 10) systems as part of a larger study of interorganizational relationships. RESULTS: A primary barrier was lack of knowledge about the services and policies of each other’s systems. Another barrier was differences in philosophy about employment and the special needs of transition-age youth with mental health needs. CONCLUSIONS: In addition to specific activities that would encourage greater interaction across three systems, results underscore the need for the child mental health system and vocational rehabilitation system to increase their involvement with and knowledge about one another. This would include training child mental health providers about employment and career development services, vocational rehabilitation providers about the role of mental health in the youngest workers, and both being involved in transition-planning that directly addresses vocational goals and support needs.
A Systematic Review of Immune Checkpoint Inhibitors in Non-Clear-Cell Renal Cancer
Authors: Palma dos Reis Ana Filipa , Simão Diana , Odeny Thomas , Rodrigues Chiara , Fontes-Sousa Mário , da Luz Ricardo , Chowdry Rajasree Pia , Welsh Sarah J. , Paller Channing , Barata Pedro C.
Published: February 2022

BACKGROUND:

Immune checkpoint inhibitors (ICI) have emerged as active therapies in the management of advanced RCC. While multiple studies have shown clinical activity of ICIs in clear cell histologies, the evidence to support their use in non-clear cell (ncc) subtypes is based on smaller prospective trials and retrospective analyses.

OBJECTIVE:

The objective of this review is to summarize the clinical outcomes of ICI-based therapies in ncc-subtypes and in tumors with sarcomatoid/rhabdoid features.

METHODS:

We performed a systematic literature search using PubMed, Google Scholar and ASCO databases. The keywords “renal cell cancer” and “immune checkpoint inhibitors” and equivalents were used and all original publications between July 2016 and July 2021 were included.

RESULTS:

We included a total of 14 publications, including two clinical trials and 12 case series. The most frequent histologies were papillary (up to 75-100%), unclassified (up to 34%) and chromophobe (up to 28%). ICI monotherapy showed some activity in both 1st and 2nd line with response rates up to 27%. ICI combination regimens yielded better activity than ICI monotherapy but, overall, a heterogeneous efficacy was noted across histologies. Overall, outcomes of ICIs were superior in tumors with sarcomatoid/rhabdoid features.

CONCLUSION:

The observed activity of ICI-based therapies was heterogeneous. Combination regimens, papillary subtype and sarcomatoid/rhabdoid features were associated with higher responses. These findings might help treatment decisions and require further validation.
Development of an inpatient rehabilitation pathway for motor functional neurological disorders: Initial reflections
Authors: Polich Ginger , Zalanowski Stacey , Maney Julie , Perez David L. , Baslet Gaston , Maggio Julie , O’Neal Mary A. , Dworetzky Barbara , Herman Seth
Published: February 2022

BACKGROUND: Emerging research supports a primary role for rehabilitation therapy alongside psychoeducation and psychotherapy in the treatment of functional neurological disorder (FND). OBJECTIVE: While consensus recommendations for physical therapists, occupational therapists, and speech and language pathologists treating FND have been published, specific recommendations for multidisciplinary FND care delivered on an inpatient rehabilitation unit are yet to be established. METHODS: This report describes one inpatient rehabilitation facility’s efforts to design and implement a clinical pathway for patients with acute-onset motor FND—patients recently hospitalized for work-up of new neurological symptoms subsequently deemed functional. RESULTS: Detailed descriptions on defining admission criteria and delivering consensus- and evidence-based multidisciplinary inpatient rehabilitation are provided. CONCLUSIONS: In the context of prospective research studies, considerably more work is needed to delineate the optimal duration and intensity of inpatient rehabilitation treatment for the management of patients with motor FND.
Inter- and intra-rater reliability of the modified modified ashworth scale in the assessment of muscle spasticity in cerebral palsy: A preliminary study
Authors: Ansari Noureddin Nakhostin , Rahimi Maryam , Naghdi Soofia , Barzegar-Ganji Zahra , Hasson Scott , Moghimi Ehsan
Published: February 2022

PURPOSE: The aim of the study was to investigate the inter- and intra-rater reliability of the Modified Modified Ashworth Scale (MMAS) in the assessment of lower extremity spasticity in children with spastic cerebral palsy (CP). METHODS: Fifteen children (10 boys) with a mean age of 8.7±3.4 years participated. Two physiotherapists rated the spasticity of the hip adductors, knee extensors, and ankle plantar flexors for inter-rater reliability. Each child was examined again by one of the physiotherapists (same physiotherapist for all of the children) for intra-rater reliability (mean interval = 7 days). A random sequence of raters and muscles tested was applied. RESULTS: The reliability of the intraclass correlation coefficients (ICC) for individual muscle groups ranged between good to excellent (ICCagreement of 0.60–0.83). The ICC values for overall inter-rater (ICCagreement = 0.82) and intra-rater reliability (ICCagreement  = 0.85) were excellent. CONCLUSION: The MMAS showed excellent reliability for the assessment of lower extremity muscle spasticity in children with cerebral palsy. However, an interpretation should be made with caution due to the small sample size and wide range of confidence interval values.
The use of extended reality (XR) for people with moderate to severe intellectual disabilities (ID): A scoping review
Authors: Maran Patricia Laura , Daniëls Ramon , Slegers Karin
Published: February 2022

BACKGROUND:

New technologies have made rapid advances in the field of assistive technologies (AT), with Extended Reality (XR) offering promising results in supporting people with mild intellectual disabilities (ID). Yet, the design and goals of programs for people with mild ID may differ from those for people with moderate and severe ID. It remains unclear how XR technologies are used for people with moderate to severe ID.

OBJECTIVE:

The study we present in this paper aimed to explore what is known from the existing scientific literature about XR-based interventions for supporting people with moderate to severe intellectual disabilities, including the features of XR content and technology that is used and factors that may impact implementation.

METHODS:

We conducted a scoping review, searching Cinahl, PubMed, LibSearch, and Google Scholar based on inclusion and exclusion criteria ensuring the focus on XR and moderate to severe ID. We adopted a qualitative content analysis approach to review the papers resulting from the search.

RESULTS:

In total, we included 16 papers in the review. Most of these focused on XR-based interventions to improve specific skills, such as navigation and daily living skills, in order to increase autonomy and independence. We found a large variety in the content and technology used in these interventions as well as in factors that the authors found to affect the implementation. These factors concern characteristics of users, of caregivers or facilitators, and of the XR environments and systems. The majority of the papers reported studies with small sample sizes, and lacked control groups and follow-up periods to measure long-term effects of XR.

CONCLUSIONS:

The use of XR for people with moderate to severe ID is an emerging field. Although many authors of the reviewed studies do acknowledge the potential of XR, further evidence is needed. Future research might explore the potential of XR as leisure activity, and might study in detail how features of the XR environment impact behaviour to inform professionals about how to approach their use of XR in order to meet the needs and preferences of people with moderate and severe ID.
The reliability of the Dutch version of the vestibular activities avoidance instrument in persons with and without dizziness
Authors: Vereeck Luc , Dunlap Pamela M. , Vanspauwen Robby , Hendriks Erwin , Whitney Susan L.
Published: February 2022

BACKGROUND: Avoidance of activities that trigger dizziness in persons with vestibular disorders may inhibit dynamic vestibular compensation mechanisms. OBJECTIVE: To determine the reliability of the Vestibular Activities Avoidance Instrument (VAAI) 81 and 9 item tool and to compare the VAAI scores in Dutch-speaking healthy adults and in patients with vestibular disorders. METHODS: A prospective cohort study was conducted including 151 healthy participants and 106 participants with dizziness. All participants completed the 81-item VAAI. Within 7 days, the VAAI was completed a second time by 102 healthy adults and 43 persons with dizziness. RESULTS: The average 81-item VAAI scores [54.8(47.1) vs. 228.1(78.3)] and 9-item VAAI scores [2.4(5.9) vs. 28.1(12)] were significantly different between healthy adults and participants with dizziness (p < 0.001). In participants with dizziness the ICC for the 81-item VAAI was 0.95 (95% CI: 0.91, 0.97) and for the 9-item VAAI was 0.92 (95% CI: 0.85, 0.95). Cronbach’s alpha for the 81-item VAAI was 0.97 and 0.85 for the 9-item VAAI. The minimal detectable change was 47.8 for the 81-item VAAI and 8.9 for the 9-item VAAI. CONCLUSIONS: Persons with dizziness have a greater tendency to avoid movements. Both test-retest reliability and internal consistency of the Dutch version of the VAAI were excellent.
Optimized chest X-ray image semantic segmentation networks for COVID-19 early detection
Authors: Gopatoti Anandbabu , Vijayalakshmi P.
Published: February 2022

BACKGROUND: Although detection of COVID-19 from chest X-ray radiography (CXR) images is faster than PCR sputum testing, the accuracy of detecting COVID-19 from CXR images is lacking in the existing deep learning models. OBJECTIVE: This study aims to classify COVID-19 and normal patients from CXR images using semantic segmentation networks for detecting and labeling COVID-19 infected lung lobes in CXR images. METHODS: For semantically segmenting infected lung lobes in CXR images for COVID-19 early detection, three structurally different deep learning (DL) networks such as SegNet, U-Net and hybrid CNN with SegNet plus U-Net, are proposed and investigated. Further, the optimized CXR image semantic segmentation networks such as GWO SegNet, GWO U-Net, and GWO hybrid CNN are developed with the grey wolf optimization (GWO) algorithm. The proposed DL networks are trained, tested, and validated without and with optimization on the openly available dataset that contains 2,572 COVID-19 CXR images including 2,174 training images and 398 testing images. The DL networks and their GWO optimized networks are also compared with other state-of-the-art models used to detect COVID-19 CXR images. RESULTS: All optimized CXR image semantic segmentation networks for COVID-19 image detection developed in this study achieved detection accuracy higher than 92%. The result shows the superiority of optimized SegNet in segmenting COVID-19 infected lung lobes and classifying with an accuracy of 98.08% compared to optimized U-Net and hybrid CNN. CONCLUSION: The optimized DL networks has potential to be utilised to more objectively and accurately identify COVID-19 disease using semantic segmentation of COVID-19 CXR images of the lungs.
ANALYSIS OF REGULATORY DOCUMENTS ON THE ARRANGEMENT OF CYCLE LANES WITHIN URBAN STREETS
Authors: Zhydkova Tetyana , Chepurna Svіtlana
Published: February 2022

Today, the global interest in cycling is growing rapidly because cycling is an ecological, comfortable, healthy mode of transport that has certain advantages over other modes of transportation. However, the infrastructure should be developed very well. The development of cycling transport is slow in Ukraine. The article analyzed the existing public regulations on the width of bicycle lanes within urban streets, as well as a comparison of public and foreign safety requirements for cyclists. The realm of application of the existing regulatory documents is provided making cycle lanes and paths during the construction, reconstruction, and overhaul of streets and roads. The emergence of normative documents on bicycle infrastructure is a positive factor in Ukraine, but a basis for the development of public standards for the organization of bike paths was adopted European standards developed 10 years ago that doesn’t take into account today's requirements, but Germany adopted new guidelines on 28 June 2020. The analysis of the normative documents on the creation of cycle lanes snowed the smallest index in the criteria of safety. Cycle lanes with one-way traffic with a width of 1.50 are marked with markings, as Ukrainian norms are allowing, but they don’t assure requirements of safety and cannot ensure the attraction of potential users, and, accordingly, the development of cycling infrastructure. When the existing regulatory documents have been developing the standard parameters of bicycles and the capabilities of experienced cyclists were taken into account, while among potential users there are different age groups, persons with disabilities, etc., as well as modifications of bicycles with dimensions different that differ from the standard parameters. These are bicycles with an additional frame for transportation and training on behavior on the streets of teenagers, special ones that allow the use of persons with disabilities, cars with trailers, tricycles, tandems, including those with a wheelchair, cycle rickshaws and the like. The development of the public normative documents should be preceded by a thorough study of contemporary normative documents of the countries of the world. Changes in the normative document are proposed in accordance with safety requirements.
FORMATION OF A MODEL OF URBAN SPACE INTEGRATED DEVELOPMENT
Authors: Kaidanovska Olena , Vasylkiv Daryna
Published: February 2022

A significant theoretical and methodological basis for the formation of public spaces as a condition for successful urban development is processed with globalization processes considered, existing contradictions and prospects are outlined. The problems of rethinking the common spaces of historic cities, updating the architectural environment, creating public communication spaces, forming new integrated functional areas, development of post-industrial territories are relevant. Architectural science and practice are aimed at achieving the goal of sustainable development in ensuring openness, security, social activity and environmental sustainability of cities, the formation of principles of economic and social stability without harming the environment, the implementation of digital technologies.

Concepts of modern city’s development from urbanism’s perspective, tendencies of urban territories’ renewal in terms of economic and social changes, models of non-automotive space are considered. The concept of the new urbanism emphasizes urban living quality backed by multi-functionality and saturation of urban environment, modern forms of architecture and planning. The quality of urban space implies the maximum realization of residents’ needs, providing opportunities for communication and social activity. It is found that public (open, community) spaces should be formed on humanistic principles, guided by social needs, be multi-functional, accessible, comfortable and safe, promote various activities of all social and age groups throughout the day, offer quality architectural and design solutions.

There has been noted the positive role of international projects of Ukrainian cities’ integrated development in strengthening the social diversity of urban architectural space, increasing the activity of citizens, significant economic results.
SPATIAL DATA INFRASTRUCTURE AND GEOINFORMATIONAL SUPPORT OF SUSTAINABLE DEVELOPMENT OF TERITORIAL COMMUNITIES
Authors: Lyashchenko Anatoliy , Karpenko Olena , Cherin Andrii
Published: February 2022

The relevance of the problem of the formation of geoinformation resources and their use for the sustainable development of the country and territorial communities is associated with the implementation of the tasks defined in the regulatory legal acts of Ukraine for the development of the national geospatial data infrastructure (NSDI), the development of comprehensive plans for the spatial development of territories and the creation of a system of urban planning cadastre.

In the article, based on the analysis of the experience of creating NIGD in developed countries, the expediency of legislative definition of the hierarchy of levels in the organizational structure of NSDI of Ukraine in accordance with the administrative-territorial structure of the country is substantiated. This will allow for a clearer definition of the powers and responsibilities of central authorities and local self-government bodies for the creation of basic and thematic geospatial datasets on the principles of generalization, integration and their coordinated monitoring based on a general methodology, general technical regulations and an agreed technical policy.

In the context of decentralization, it is advisable to develop the basic level of the NSDI of Ukraine on the basis of the systems of the urban planning cadastre of territorial communities, the geoinformation resources of which contain integrated information about the current state and prospects of the development of the territory. The priority for the development of NSDI and the development of modern urban planning documentation for solving the problems of creating information resources of a digital topographic basemap for the territory of the country and territorial communities to ensure the coordinate-spatial consistency of all sets at all levels of the NSDI are substantiated.
DISCRETE-TO-CONTINUUM MODELS IN ANALYSIS AND OPTIMIZATION (MINIMIZATION) OF DYNAMIC LOADS IN ELASTIC ELEMENTS/CARRIER CABLES OF HOISTING MACHINERY USED IN URBAN PLANNING AND TRANSPORT TECHNOLIGIES (Part II)
Authors: Chovnyuk Yuriy , Cherednichenko Petro , Ostapushchenko Olga , Vasileva Hanna
Published: February 2022

The analysis dynamic loads in elastic elements (ropes) of hoisting machines and cranes used in urban planning, loading and unloading operations and transport technologies was carried out. Discrete, continuous and discrete-continuous models of crane lifting mechanisms considered. In these models the elastic elements (ropes) are initially considered as elements that have elastic properties of the system with concentrated parameters. Therefore the rope in the lifting mechanism is taken into account as a certain rigidity spring. However, this approach is not correct for quite long ropes (more than 10 meters), in which wave processes can occur during lifting/lowering of loads. These processes can significally increase the dynamic loads − the so-called rope model as a system with distributed parameters. According to the authors of this work, the most correct approach is one that takes into account the discrete properties of the rope (more than 10 meters) itself. That is, the analysis of dynamic loads is carried out within a discrete-continuous model.

The work consists of several parts, in each of which the dynamic loads in the ropes within each of above starting/braking of the crane lifting mechanisms models are comprehensively and in detail considered. Also parameters of work processes at which the above loads become optimal in magnitude calculated (that is, take the minimum values for different ways of lifting cargo: a)“from the base” (“from the ground”), b)“from the weith”, as, incidentally, the coefficient of dynamism.
Assessment of toxicity and mechanism of the drug (camphoric acid derivative) effect on the organism
Authors:   State Institution «V. Danilevsky Institute of Endocrine Pathology Problems, National Academy of Medical Sciences of Ukraine», Kharkiv, Palagina І.А. , Kudria M.Ya. ,   State Institution «V. Danilevsky Institute of Endocrine Pathology Problems, National Academy of Medical Sciences of Ukraine», Kharkiv
Published: February 2022

The drugs, their active ingredients under conditions of manufacture and pharmaceutical waste at the ingress in the environment can be hazardous to the human health. The toxicological examination enables to predict the risk of their adverse effects on the organism with a determination of the prior criteria of hazard. Objectives: We defined the probable toxic effects and the mechanism of their formation under various conditions of the exposure of the original anti-diabetic drug based on a camphoric acid derivative (Diacamph - DCMPh) under various conditions of its exposure. Methods: The peculiarities of DCMPh effect on the organism were studied in the acute, sub-acute, and chronic experiments under different conditions of the drug introduction to animals by the indicators characterizing a state of the organism in a whole and the separate organs and systems of the organism and individual organs and systems, including prooxidant- antioxidant and immune systems. Its possible allergenic and mutagenic effects were studied in a separate run of the experiments. Results: Our studies showed that DCMPh is virtually non-toxic in terms of an acute toxicity, does not accumulate, has no local irritant, mutagenic and allergenic effects, but is capable of the skin resorption. Adverse effect of DCMPh on the organism under its oral and inhalation introduction are realized through the disturbance of the prooxidant-antioxidant balance and cellular components of the immunological resistance. We determined a high sensitivity of lungs to the inhalation impact of DCMPh, taking into account an increase of the free radical oxidation in the organ tissue on the background of the weakening of the antioxidant system and a decrease of the functional reserve of neutrophils manifested in the aftereffect period. The high sensitivity of the lungs to the inhalation effect of DCMPh was determined taking into account the increase in free radical oxidation in the organ tissue on the background of the weakening of the antioxidant system and the decrease in the functional reserve of neutrophils, which manifests itself during the aftereffect period. Conclusions: Taking into account the mechanism of toxic action, the maximum permissible concentration of DCMPh in the air of the working area was substantiated at the level of 0.4 mg / m3, hazard class II.
Pengaruh Dana Pihak Ketiga Terhadap Laba Bersih Pada PT. Bank Negara Indonesia (Persero), Tbk
Authors: Jamhuriah Jamhuriah , Nurhayat Nurhayat
Published: February 2022

Dana Pihak Ketiga (DPK) merupakan sumber dana terpenting bagi kegiatan operasional suatu bank dan merupakan ukuran keberhasilan bank jika mampu membiayai operasinya dari sumber dana ini sehingga tujuan dari penelitian ini adalah untuk mengetahui sejauh mana pengaruh Dana Pihak Ketiga (DPK) terhadap  Laba Bersih PT. Bank Negara Indonesia (Persero), Tbk periode tahun 2010-2019. Penelitian ini dikategorikan ke dalam jenis penelitian asosiatif kausal dengan metode kuantitatif. Populasi pada penelitian ini merupakan seluruh data perusahaan sepanjang periode tahun 1992 sampai dengan tahun 2019. Sampel pada penelitian ini Laporan Keuangan Tahunan diambil 10 tahun yaitu tahun 2010-2019 dengan teknik purposive sampling. Sumber data yaitu diperoleh dari data sekunder. Alat analisis data menggunakan regresi linear sederhana, koefisien korelasi, koefisien determinasi dan uji hipotesis (Uji-T). Hasil penelitian ini membuktikan bahwa DPK (Dana Pihak Ketiga) berpengaruh positif dan signifikan terhadap  laba bersih pada PT. Bank Negara Indonesia (Persero), Tbk. Hal ini mengindikasikan bahwa semakin banyak simpanan nasabah yang dihimpun PT. Bank Negara Indonesia (Persero), Tbk maka dapat meningkatkan kegiatan usaha bank sehingga memperoleh laba bersih yang optimal. Hal ini dapat dilihat pada hasil uji t yang lebih besar dari nilai t-tabel (9,929>2,306) dengan tingkat signifikan yang lebih kecil dari 0,05 (0,000<0,05) sehingga H0 ditolak dan Ha diterima artinya terdapat pengaruh langsung antara Dana Pihak Ketiga terhadap laba bersih pada PT. Bank Negara Indonesia (Persero), Tbk. Kata Kunci : Dana Pihak Ketiga (DPK); Laba Bersih
Pentingnya Transparansi Laporan Keuangan terhadap Kinerja Individu
Authors: Farouk Jenyssa Faizah
Published: February 2022

Tujuan dilakukannya penelitian ini adalah untuk mengetahui pentingnya transparansi laporan keuangan terhadap kinerja individu. Metode penelitian yang digunakan pada jurnal ini adalah metode kuantitatif dengan sampel yang diambil yaitu sebanyak 23 responden.Teknik pengumpulan data yang digunakan adalah dengan mengisi kuisioner yang dilakukan oleh responden. Hasil penelitian ini menunjukkan bahwa transparansi laporan keuangan yang dilakukan oleh perusahaan akan mempengaruhi kinerja setiap individu yang bekerja pada perusahaan tersebut. Karena dengan mengetahui laporan keuangan yang ada maka para responden berpendapat bahwa para pekerja pada perusahaan tersebut akan tahu apa yang akan mereka lakukan setelah hasil yang mereka dapat, yaitu dengan meningkatkan kinerja mereka ataupun dengan menstabilkan kinerja yang sudah mereka kerahkan. Kata Kunci: Transparansi; Kinerja; Laporan Keuangan.
Analisis Non Performing Loan (NPL) Pada Bank BRI Tbk
Authors: Aristianti Astri , Nurulrahmatiah Nafisah
Published: February 2022

Penelitian ini bertujan untuk Untuk mengetahui Seberapa besar NON PERFORMING LOAN (NPL) pada PT.  Bank Rakyat Indonesia (BRI), tbk, Penelitian ini merupakan penelitian Deskriptif Penelitian deskriptif yaitu suatu metode dalam penelitian yang dilakukan untuk mengetahui nilai variabel mandiri, baik satu variabel atau lebih (independent) tanpa membuat perbadingan, Adapun instrument penelitian yang digunakan dalam mengumpulkan data adalah laporan keuangan PT. Bank BRI Tbk berupa laporan rasio keuangan dari tahun 2010-2019, Populasi dalam penelitian ini adalah berupa laporan keuangan pada PT BANK BRI Tbk. Sejak tahun 1989-2019 selama 30 tahun Adapun teknik pengambilan sampel yang digunakan oleh peneliti dalam penelitian ini adalah teknik purposive sampling, Jenis data yang di gunakan dalam penelitian ini adalah Data Kualitatif, Teknik pengumpulan data yang di gunakan yaitu (a) studi pustaka (b) dokumentasi, Teknik Analisis data menggunakan Analisis Keuangan dan uji t satu sampel independent, hasil penelitian ini adalah NON PERFORMING LOAN (NPL) pada bank BRI berada dibawah standar kriteria yang ditetapkan 5% di katakana Baik. Kata Kunci: Non Performing Loan (NPL)
Analisa Peningkatan Kualitas Pelayanan Terhadap Kepuasan Konsumen Dengan Metode Importance Performance Analysis (IPA) dan Potential Gain in Customer Value (PGCV) (Studi Pada Tanto Sport Surabaya)
Authors: Ihzah Muchammad Yusril , Sulistyawati Lisa
Published: February 2022

Kualitas pelayanan adalah persepsi konsumen atas pelayanan yang nyata mereka peroleh dengan pelayanan yang sesungguhnya mereka inginkan terhadap suatu pelayanan. Pelayanan yang bertaraf tinggi akan menghasilkan kepuasan yang tinggi bagi konsumen. Kepuasan konsumen adalah perbandingan persepsi konsumen antara kinerja yang diharapkan dengan kinerja nyata di lapangan. Ketika kinerja nyata lebih tinggi dibandingkan dengan harapan konsumen maka konsumen akan merasakan kepuasan dan sebaliknya. Pada kasus di Tanto Sport Surabaya, kualitas pelayanan yang diberikan belum maksimal dalam memuaskan konsumen, untuk itu perlu dianalisa faktor apa saja yang berpengaruh. Dilihat dari lima dimensi kualitas pelayanan yang meliputi Reliability, Responsiveness, Assurance, Empathy, Tangible, di Tanto Sport Surabaya yang dianalisis melalui Importance Performance Analysis (IPA) dan Potential Gain in Customer Value (PGCV). Maka hasilnya dari dua puluh indikator yang termasuk di lima dimensi tersebut ada tiga indikator penting yang perlu dilakukan perbaikan yaitu mengenai area parkir yang luas dan mudah, ketepatan waktu buka dan waktu tutup, dan karyawan memberikan informasi yang jelas dan mudah dipahami. Keywords: Kualitas Pelayanan; Kepuasan Konsumen; Importance Performance Analysis (IPA); Potential Gain in Customer Value (PGCV)
Pengaruh Akuntabilitas Pengurus Organisasi Dalam Pengelilaan Keuangan Terhadap Kualitas Laporan Pertanggungjawaban (LPJ) Program Kerja
Authors: Wardani Dewi Kusuma , Primastiwi Anita , Usun Febby Gloria
Published: February 2022

AbstrakTujuan dari penelitian ini adalah untuk mengetahui pengaruh akuntabilitas pengurus organisasi dalam pengelolaan keuangan terhadap kualitas laporan pertanggungjawaban program kerja (LPJ). Penelitian ini menggunakan jenis penelitian kuantitatif. Pengumpulan data menggunakan data primer dengan membagikan kuesioner kepada mahasiswa yang mengikuti kepengurusan organisasi kelembagaan dan UKM di Universitas Sarjanawiyata Tamansiswa Yogyakarta. Pengambilan sampel dilakukan dengan menggunakan teknik convenience sampling. Data penelitian dikumpulkan melalui menggunakan kuesioner melalui link google form dan dikirimkan via whatsapp kepada mahasiswa. Jumlah kuesioner yang diolah ialah sebanyak 100 kuesioner. Data penelitian dianalisis dengan menggunakan path analysis. Penelitian ini menyatakan bahwa akuntabilitas dalam pengelolaan keuangan organisasi di Universitas Sarjanawiyata Tamansiswa berpengaruh positif terhadap kualitas laporan pertanggungjawaban program kerja.Kata Kunci: Akuntabilitas, Kualitas Laporan Pertanggungjawaban (LPJ) AbstractThe purpose of this study was to determine the effect of organizational management accountability in financial management on the quality of the work program accountability report (LPJ). This research uses quantitative research. Collecting data using primary data by distributing questionnaires to students who take part in the management of institutional and SME organizations at the Bachelorwiyata University Tamansiswa Yogyakarta. Sampling was done using convenience sampling technique. Research data was collected using a questionnaire via a google form link and sent via whatsapp to students. The number of questionnaires that were processed were 100 questionnaires. The research data were analyzed using path analysis. This study states that accountability in organizational financial management at the University of Sarjanawiyata Tamansiswa has a positive effect on the quality of work program accountability reports.Keywords: Accountability, Quality of Accountability Report
Analisis Perbedaan Pendapatan Usaha Kuliner Sebelum dan Selama Pandemi Covid-19
Authors: Hajati Dayat Ikhsan
Published: February 2022

Penelitian ini bertujuan untuk menganalisis perbedaan pendapatan baik omzet maupun profit usaha kuliner selama pandemi COVID-19. Penelitian ini dilaksanakan menggunakan pendekatan penelitian kuantitatif dengan jenis penelitian studi kasus dengan populasi adalah usaha kuliner di Kecamatan Pulau Laut Utara Kabupaten Kotabaru Provinsi Kalimantan Selatan. Teknik pengambilan sampel dalam penelitian ini menggunakan sampling jenuh dengan jumlah sampel sebanyak 46 usaha kuliner. Pengumpulan data dalam penelitian ini menggunakan observasi, studi kepustakaan dan kuesioner. Teknik analisis data yang digunakan dalam penelitian ini menggunakan analisis statistik deskriptif dan analisis statistik inferensial dengan Wilcoxon Signed Rank Test. Hasil penelitian yang dilakukan menunjukkan bahwa 1) terdapat perbedaan signifikan baik omzet maupun profit yang diperoleh pelaku usaha kuliner dalam bentuk rata-rata penurunan omzet dan profit antara sebelum dan saat terjadi Pandemi COVID-19. Keywords:  Pendemi; COVID-19; Usaha Kuliner
Pemanfaatan Lubang Resapan Biopori Sebagai Alih Fungsi Lahan Dan Upaya Mitigasi Banjir
Authors: Dianty Marelianda Al , Arbaningrum Rizka , Khalisa Shafira
Published: February 2022

Isi Banjir merupakan fenomena alam yang akan selalu berulang terjadi. Kombinasi penggunaan LRB dan analisa hidologi di jelaskan di penelitian ini dengan mengambil contoh Perumahan di Kawasan Tangerang Selatan yang mengalami perkembangan pesat. Urbanisasi menyebabkan luas lahan hijau yang ada sebagai daerah resapan air dan pemukiman tidak seimbang. Menjadikan penyebab utama terjadinya banjir. Dari hasil pengolahan data curah hujan, dapat di analisis intensitas curah hujan dengan menggunakan pendekatan diagram hyetograph. Debit banjir rencana yang didapat dengan memodelkan dengan program bantuan, yaitu SWMM 5.0 untuk periode 100 tahun, sehingga didapat debit banjir rencana sebesar 0.98 m³/detik. Dari hasil penelitian, diperoleh jumlah LRB yang dapat diterapkan adalah 750 buah pada tepi jalan dengan bentang 750 meter di dekat saluran primer dan jarak antar lubang resapan biopori sepanjang 1 meter. Debit yang dapat diserap oleh lubang resapan biopori sebesar 0.328125 m³/detik. Besar pemanfaatan lubang resapan biopori (LRB) dalam mereduksi beban drainase di Perumahan tersebut sebesar 33.48%. Penggunaan lubang resapan biopori (LRB) merupakan sistem yang efektif yang bisa di lakukan masing masing di rumah saja dalam rangka menangani permasalahan banjir. LRB juga dapat dilakukan di rumah saja pada saat pandemic sebagai upaya pemulihan sosial dan ekonomi masyarakan di bidang penanggulangan banjir.
Pengaruh Gaya Kepemimpinan Dan Disiplin Kerja Terhadap Kinerja Karyawan Pada PT FA Antares Medika BSD City
Authors: Hermawati Rahmi , Hastuti Tri , Lysander Mohammad Ahyar Syafwan
Published: February 2022

Penelitian ini bertujuan untuk mengetahui adakah pengaruh atau seberapa besarkah pengaruh variabel Gaya kepemimpinan dan disiplin kerja terhadap kinerja karyawan PT. Fa Antares Medika – BSD City. Metode yang digunakan dalam penelitian ini adalah metode kuantitatif, dimana teknik pengumpulan data yang digunakan dengan penyebaran kuesioner,Observasi dan data pustaka. Sampel dalam penelitian ini adalah karyawan PT. Fa Antares Medika – BSD City yang berjumlah 50 orang dengan metode sampel jenuh. Metode yang digunakan adalah  regresi linear berganda. Dari hasil pengolahan data menggunakan SPSS 26 didapati bahwa Adjusted R Square sebesar 52,7%. Artinya, variabel Gaya Kepemimpinan dan Disiplin Kerja dapat menjelaskan variabel Kinerja sebesar 52,7%. Selisihnya, dipengaruhi oleh variabel lain yang tidak digunakan dalam penelitian ini. Hasil dari penelitian ini menyimpulkan bahwa secara parsial, variabel Gaya kepemimpinan dan disiplin kerja berpengaruh signifikan terhadap kinerja karyawan PT. Fa Antares Medika – BSD City. Secara simultan Gaya kepemimpinan dan disiplin kerja berpengaruh terhadap Kinerja karyawan.
Pengaruh Capital Adequacy Ratio Dan Return On Equity Terhadap Loan To Deposit Ratio Pada PT. Bank Mandiri (Persero) Tbk Periode 2011-2020
Authors: Lutfi Asep Muhammad , Julaiha Siti
Published: February 2022

Penelitian ini bertujuan untuk menganalisis Pengaruh Capital Adequacy Ratio (CAR) Dan Return On Equity (ROE) Terhadap Loan To Deposit Ratio (LDR) Pada PT. Bank Mandiri (Persero), Tbk. Penelitian ini menggunakan data laporan keuangan pada perusahaan yang terdaftar dalam Bursa Efek Indonesia periode tahun 2011-2020. Analisa data dilakukan dengan metode statistik deskriptif kuantitatif, uji asumsi klasik dan pengujian hipotesis dengan metode regresi linier berganda. Data diolah dan dianalisa dengan menggunakan program aplikasi SPSS vers 26. Hasil dari penelitian ini menunjukkan bahwa variabel Capital Adequacy Ratio (CAR) berpengaruh negatif dan signifikan terhadap Loan To Deposit Ratio (LDR) dengan hasil Thitung sebesar -2,979 dan nilai signifikan sebesar 0,021. Untuk variabel Return On Equity (ROE) tidak berpengaruh terhadap Loan To Deposit Ratio (LDR) dengan hasil Thitung sebesar -1,263 dan nilai signifikan sebesar 0,247. Dan selanjutnya secara simultan Capital Adequacy Ratio (CAR) Dan Return On Equity (ROE) berpengaruh positif dan signifikan yang terhitung menggunakan Loan To Deposit Ratio (LDR). hal ini dapat dilihat dari Fhitung sebesar 11.502 dan nilai signifikan sebesar 0,006 dengan hasil (R2) 0,767 atau 76,7% dan sisanya 23,3% dipengaruhi oleh lainnya.
Pengaruh Motivasi Terhadap Produktivitas Karyawan Pada PT Collection Lestari Di Jakarta
Authors: Rosilawati Eka , Sutoro Moh.
Published: February 2022

Penelitian ini bertujuan untuk mengetahui pengaruh motivasi terhadap produktivitas karyawan pada PT. Collection Lestari di Jakarta.Metode yang digunakan adalah explanatory research dengan sampel sebanyak 73 responden. Teknik analisis menggunakan analisis statistik dengan pengujian regresi, korelasi, determinasi dan uji hipotesis.Hasil penelitian ini variabel motivasi diperoleh nilai rata-rata skor sebesar 3,805 dengan kriteria baik. Variabel produktivitas karyawan diperoleh nilai rata-rata skor sebesar 3,881 dengan kriteria baik. Motivasi berpengaruh positif dan signifikan terhadap produktivitas karyawan dengan nilai persamaan regresi Y = 14,003 + 0,652X, dan nilai koefisien korelasi 0,778 atau memiliki tingkat hubungan yang kuat dengan nilai determinasi 60,5%. Uji  hipotesis diperoleh signifikansi 0,000 < 0,05.
Pengaruh Perputaran Modal Kerja Terhadap Profitabilitas Pada PT Intikeramik Alamasri Indonesia Tbk Periode 2013-2020
Authors: Rahmi Eva Kania Kurnia , Zulfitra Zulfitra
Published: February 2022

Penelitian ini bertujuan untuk mengetahui pengaruh Perputaran modal kerja terhadap Profitabilitas pada PT. Intikeramik Alamasri Indonesia Tbk Periode 2013-2020.Metode yang digunakan adalah explanatory research. Teknik analisis menggunakan analisis statistik dengan pengujian regresi, korelasi, determinasi dan uji hipotesis.Hasil penelitian ini variabel Perputaran modal kerja diperoleh nilai rata-rata sebesar 3,552%. Variabel Profitabilitas diperoleh nilai rata-rata 8,380%. Perputaran modal kerja berpengaruh positif dan signifikan terhadap Profitabilitas dengan nilai persamaan regresi Y = 1,311 + 0,002X, dan nilai koefisien korelasi 0,724 atau memiliki tingkat hubungan yang kuat dengan nilai determinasi 52,4%. Uji  hipotesis diperoleh signifikansi 0,042 < 0,05.
Pelatihan Mendeley Untuk Penulisan Sitasi Karya Ilmiah Bagi Mahasiswa Universitas Islam Kadiri
Authors: Idris Ahmad , Hendratmoko Suseno , Lestari Dina Ayu , Mulyono Ahmad Agus Tri
Published: February 2022

Tujuan kegiatan pengabdian adalah memberikan pelatihan penggunaan referensi manager mendeley kepada mahasiswa Universitas Islam Kadiri dalam penulisan skripsi. Berdasarkan pengamatan penulis masih banyak ditemukan mahasiswa pada saat penulisan skripsi atau karya ilmiah masih menggunakan kutipan dan daftar pustaka secara manual yang dikhawatirkan rawan kesalahan dalam penyusunannya. Pelatihan diadakan secara tatap muka terbatas dengan jumlah peserta 15 orang mahasiswa bertempat di ruang kelas kampus Universitas Islam Kadiri. Hasil kegiatan adalah meningkatnya kemampuan mahasiswa dalam penggunaan aplikasi mendeley dan mampu membuat kutipan dan daftar pustaka menggunakan referensi manager. Harapannya kegiatan pelatihan seperti ini rutin dilaksanakan kepada mahasiswa.