bluuebunny/crossref_metadata_2025 huggingface dataset:
Lessons from diversity of directed evolution experiments by an analysis of 3,000 mutations
Authors: Zhao Jing , Kardashliev Tsvetan , Joëlle Ruff Anna , Bocola Marco , Schwaneberg Ulrich
Published: June 2014

Diversity generation by random mutagenesis is often the first key step in directed evolution experiments and screening of 1,000–2,000 clones is in most directed evolution campaigns sufficient to identify improved variants. For experimentalists important questions such as how many positions are mutated in the targeted gene and what amino acid substitutions can be expected after screening of 1,000–2,000 clones are surprisingly not answered by a statistical analysis of mutant libraries. Therefore three random mutagenesis experiments (epPCR with a low‐ and a high‐mutation frequency and a transversion‐enriched sequence saturation mutagenesis method named SeSaM‐Tv P/P) were performed on the lipase BSLA and in total 3,000 mutations were analyzed to determine the diversity in random mutagenesis libraries employed in directed evolution experiments. The active fraction of the population ranged from 15% (epPCR‐high), to 52% (SeSaM‐Tv P/P), and 55% (epPCR‐low) which correlates well with the average number of amino acid substitutions per protein (4.1, 1.6 and 1.1). In the epPCR libraries transitions were the predominant mutations (>72%), and >82% of all mutations occurred at A‐ or T‐nts. Consecutive nucleotide (nt) mutations were obtained only with a low fraction (2.8%) under highly error‐prone conditions. SeSaM‐Tv P/P was enriched in transversions (43%; >1.7‐fold more than epPCR libraries), and consecutive nt mutations (30.5%; 11‐fold more than epPCR‐high). A high fraction of wild‐type BSLA protein (33%) was found in the epPCR‐low mutant library compared to 2% in epPCR‐high and 13% in SeSaM‐Tv P/P. An average of 1.8–1.9 amino acid substitutions per residue was obtained with epPCR‐low and ‐high compared to 2.1 via SeSaM‐Tv P/P. The chemical composition of the amino acid substitutions differed, however, significantly from the two epPCR methods to SeSaM‐Tv P/P. Biotechnol. Bioeng. 2014;111: 2380–2389. © 2014 Wiley Periodicals, Inc.
Cell retention by encapsulation for the cultivation of Jurkat cells in fixed and fluidized bed reactors
Authors: Kaiser P. , Werner M. , Jérôme V. , Hübner H. , Buchholz R. , Freitag R.
Published: June 2014

Jurkat cells are accepted model cells for primary human T lymphocytes, for example, in medical research. Their growth to tissue‐like cell densities (up to 100 × 106 cells/mLcapsule) in semi‐permeable (molecular weight cut off <10,000 Da) sodium cellulose sulfate/poly(diallyldimethylammonium chloride) polyelectrolyte capsules has previously been shown by us [Werner et al. (2013). Use of the mitochondria toxicity assay for quantifying the viable cell density of microencapsulated jurkat cells. Biotechnol Prog 29(4): 986–993]. Herein, we demonstrate that encapsulation can be used to retain the cells in continuously operated bioreactors, which opens new possibilities for research, for example, the use of Jurkat cells in pulse response experiments under steady state conditions. Two reactor concepts are presented, a fluidized and a fixed bed reactor. A direct comparison of the growth kinetics in batch and repeated batch spinner cultivations, that is, under conditions where both encapsulated and non‐encapsulated cells can be cultivated under otherwise identical conditions, showed that maximum specific growth rates were higher for the encapsulated than for the non‐encapsulated cells. In the subsequent batch and repeated batch bioreactor experiments (only encapsulated cells), growth rates were similar, with the exception of the fixed bed batch reactor, where growth kinetics were significantly slower. Concomitantly, a significant fraction of the cells towards the bottom of the bed were no longer metabolically active, though apparently not dead. In the repeated batch fluidized bed reactor cellular division could be maintained for more than two weeks, albeit with a specific growth rate below the maximum one, leading to final cell densities of approximately 180 × 106 cell/gcapsule. At the same time, the cell cycle distribution of the cells was shifted to the S and G2/M phases. Biotechnol. Bioeng. 2014;111: 2571–2579. © 2014 Wiley Periodicals, Inc.
Simultaneous determination of cinnamaldehyde and its metabolite in rat tissues by gas chromatography–mass spectrometry
Authors: Zhao Hang , Yang Qian , Xie Yanhua , Sun Jiyuan , Tu Honghai , Cao Wei , Wang Siwang
Published: June 2014

Cinnamaldehyde (CA), an active ingredient isolated from the traditional Chinese medicine Cortex Cinnamomi, has a wide range of bioactivities. To clarify the distribution characteristics of CA, a selective and sensitive method utilizing gas chromatography–mass spetrometry was initially developed for simultaneously determining the concentration of CA and its metabolite cinnamyl alcohol in rat tissues. Selected ion masses of m/z 131, 105 and 92 were chosen, and separation of the analytes was performed on a DB‐5 ms (30 m × 0.25 mm, 0.25 µm, thickness) capillary column by gas chromatography–mass spectrometry. The calibration curves demonstrated good linearity and reproducibility over the range of 20–2000 and 20–4000 ng/mL for various tissue samples. Recoveries ranged from 86.8 to 107.5%, while intra‐ and interday relative standard deviations were all <11.3%. The analysis method was successfully applied in tissue distribution studies for CA and cinnamyl alcohol. As CA and cinnamyl alcohol may inter‐convert to one another, simultaneous determination of both analytes provides a comparative and accurate data for tissue study. The concentrations of CA and cinnamyl alcohol remaining in spleen were the highest among the main organs, including heart, liver, spleen, lung, kidney and brain. In addition, there was no long‐term accumulation of CA in rat tissues. Copyright © 2014 John Wiley & Sons, Ltd.
Facile LC‐UV methods for simultaneous monitoring of ciprofloxacin and rosuvastatin in API, formulations and human serum
Authors: Arayne M. Saeed , Sultana Najma , Tabassum Arman
Published: June 2014

An efficient, selective and cost‐effective liquid chromatographic assay was developed and validated for the simultaneous quantification of ciprofloxacin and rosuvastatin in Active Pharmaceutical Ingredients (API), pharmaceutical formulations and in human serum. The chromatographic system consisted of mobile phase methanol–water, 90:10 v/v at pH 3.0 adjusted with o‐phosphoric acid, pumped at 1.0 mL/min through a prepacked Purospher Star C18 (5 µm, 25 × 0.46 cm) column and effluent was monitored at the isosbestic point (255 nm) as well as at the λmax of individual drugs (243 and 271 nm). The method was validated over a linear concentration range of 0.25–15 µg/mL for ciprofloxacin and 0.33–20 µg/mL for rosuvastatin (r2 ≥ 0.999). The ranges of reliable response (limits of detection and quantitation) for ciprofloxacin were 3–15 and 9–45 ng/mL and 17–29 and 52–88 ng/mL, respectively, for rosuvastatin in all API, pharmaceutical formulations and human serum. Analytical recovery from human serum was >98% and relative standard deviation (RSD) was <2. The accuracies were 97.13–102.55 and 97.41–101.31% and precisions in RSD were 0.04–1.90 and 0.02–1.23% for ciprofloxacin and rosuvastatin, respectively. No matrix interferences, ion suppression/enhancement and carry‐over were detected. The total assay run time was less than 5 min. In another study, for optimum performance the detector was programmed for multiwavelength scanning at the absorption maxima of each component. Consequently, the linearity range was improved and limit of detection and quantitation values were down to 1–4 and 4–12 ng/mL for ciprofloxacin and 3–5 and 9–15 ng/mL for rosuvastatin, respectively. The validation parameters fitted ICH guidelines through the isosbestic and individual λmax approach. The small sample volume and simplicity of preparation make this method suitable for use in human serum samples, pharmaceutical formulations, quality control, drug–drug interaction studies, clinical laboratories, drug research centers and forensic medical centers. Copyright © 2014 John Wiley & Sons, Ltd.
Application of a sensitive and specific LC‐MS/MS method for determination of eriodictyol‐8‐C‐β‐d‐glucopyranoside in rat plasma for a bioavailability study
Authors: Qiu Feng , Fu Shujun , Zhang Xinshi , Gong Muxin , Wang Manyuan
Published: June 2014

This study is the first to detail the development and validation of a rapid, sensitive and specific LC‐ESI‐MS/MS method for the determination of eriodictyol‐8‐C‐β‐d‐glucopyranoside (EG) in rat plasma. A simple protein precipitation method was used for plasma sample preparation. Chromatographic separation was successfully achieved on an Agilent Zorbax XDB C18 column (2.1 × 50 mm, 3.5 µm) using a step gradient program with the mobile phase of 0.1% formic acid aqueous solution and acetonitrile with 0.1% formic acid. EG and the internal standard (IS) were detected using an electrospray negative ionization mass spectrometry in the multiple reaction monitoring mode. This method demonstrated good linearity and did not show any endogenous interference with the active compound and IS peaks. The lower limit of quantification of EG was 0.20 ng/mL in 50 μL rat plasma. The average recoveries of EG and IS from rat plasma were both above 80%. The inter‐day precisions (relative standard deviation) of EG determined over 5 days were all within 15%. The present method was successfully applied to a quantification and bioavailability study of EG in rats after intravenous and oral administration. The oral absolute bioavailability of EG in rats was estimated to be 7.71 ± 1.52%. Copyright © 2014 John Wiley & Sons, Ltd.
HILIC‐MS‐based shotgun metabolomic profiling of maternal urine at 9–23 weeks of gestation – establishing the baseline changes in the maternal metabolome
Authors: Trivedi Drupad K. , Iles Ray K.
Published: June 2014

In this data‐rich age it is no longer necessary to methodically isolate, characterize and measure specific molecules. What is important is to identify which of the hundreds or thousands of resolved and measured ‘unknown’ molecules are potentially associated with the pathophysiology of interest. We have taken LC‐MS data from pregnancy urine and applied SIMCA P+ data analysis software in shotgun metabolomics to search the large amount of data for significant metabolite changes that occur in the transition from the first to early second trimester of pregnancy. Seventy‐two individual urine samples were examined spanning 9–23 weeks of gestation. Three‐hundred and eighty‐three ions were identified and variations were mapped between profiles of different gestational age and the significance quantified. In urine collected during pregnancy, the transition from first to early second trimester revealed a relatively steady pattern of metabolites except for four that showed a dramatic fall in abundance as pregnancy progressed from the first to second trimester. The pattern of changes in urinary metabolites identified by Zwitterionic Hydrophilic Liquid Interaction Chromatography (ZIC‐HILIC) coupled to mass spectrometry was evaluated and we established a baseline of changes from which a search for metabolomic markers associated with clinical pathologies of pregnancy can be made as a part of wider ultraomics study. Copyright © 2014 John Wiley & Sons, Ltd.
Comparisons between the attitudes of medical and dental students toward the clinical importance of gross anatomy and physiology
Authors: Olowo‐Ofayoku Anthony , John Moxham Bernard
Published: June 2014

Marked changes are occurring within both the medical and dental curricula and new ways of teaching the basic sciences have been devised and traditional methods (e.g., dissection for gross anatomy and of bench‐based animal preparations for physiology) are increasingly no longer the norm. Although there is much anecdotal evidence that students are not in favor of such changes, there is little evidence for this based on quantitative analyses of students' attitudes. Using Thurstone and Chave attitude analyses, we assessed the attitudes of first year medical and dental students at Cardiff University toward gross anatomy and physiology in terms of their perceived clinical importance. In addition, we investigated the appropriateness (“fitness for purpose”) of teaching methodologies used for anatomy and physiology. The hypotheses tested recognized the possibility that medical and dental students differed in their opinions, but that they had a preference to being taught gross anatomy through the use of dissection and had no preference for physiology teaching. It was found that both medical and dental students displayed positive attitudes toward the clinical relevance of gross anatomy and that they preferred to be taught by means of dissection. Although both medical and dental students displayed positives attitudes toward the clinical relevance of physiology, this was greater for the medical students. Both medical and dental students showed a preference for being taught physiology through didactic teaching in small groups but the medical students also appreciated being taught by means of practicals. Overall, this study highlights the expectations that students have for the basic science foundation teaching within their professional training and signals a preference for being taught experientially/practically. Differences were discerned between medical and dental students that might reflect the direct association between systems physiology and pathophysiology and the application of this knowledge within the medical field in comparison to the dental field, which is heavily skill‐based. Clin. Anat. 27:976–987, 2014. © 2014 Wiley Periodicals, Inc.
A Tailor‐Made “Tag–Receptor” Affinity Pair for the Purification of Fusion Proteins
Authors: Pina Ana S. , Guilherme Márcia , Pereira Alice S. , Fernandes Cláudia S. M. , Branco Ricardo J. F. , El Khoury Graziella , Lowe Christopher R. , Roque A. Cecília A.
Published: June 2014

A novel affinity “tag–receptor” pair was developed as a generic platform for the purification of fusion proteins. The hexapeptide RKRKRK was selected as the affinity tag and fused to green fluorescent protein (GFP). The DNA fragments were designed, cloned in Pet‐21c expression vector and expressed in E. coli host as soluble protein. A solid‐phase combinatorial library based on the Ugi reaction was synthesized: 64 affinity ligands displaying complementary functionalities towards the designed tag. The library was screened by affinity chromatography in a 96‐well format for binding to the RKRKRK‐tagged GFP protein. Lead ligand A7C1 was selected for the purification of RKRKRK fusion proteins. The affinity pair RKRKRK‐tagged GFP with A7C1 emerged as a promising solution (Ka of 2.45×105 M−1). The specificity of the ligand towards the tag was observed experimentally and theoretically through automated docking and molecular dynamics simulations.
ChemInform Abstract: Turning Gold into “Diamond”: A Family of Hexagonal Diamond‐Type Au‐Frameworks Interconnected by Triangular Clusters in the Sr—Al—Au System.
Authors: Palasyuk Andriy , Grin Yuri , Miller Gordon J.
Published: June 2014

Different intermetallic compounds containing three‐dimensional tetrahedral frameworks of Au atoms similar to hexagonal diamond are obtained from melts of the Sr‐Au‐Al systems: (I) hexagonal SrAl3‐xAu4+x (0.06 ≤ x ≤ 0.46; space group P$\bar 6$2m, Z = 3); (II) orthorhombic SrAl2‐yAu5+y (y ≤ 0.05; space group Pnma, Z = 4); (III) Sr2Al2‐zAu7+z (z = 0.32; space group C2/c, Z = 4); and (IV) rhombohedral Sr2Al3‐wAu6+w (w ≤ 0.18; space group R$\bar 3$c, Z = 6).
ChemInform Abstract: An Alternative Crystal Structure of Yb26B12O57 — X‐Ray Structure Determination on Flux‐Synthesized Single Crystals.
Authors: Reckeweg Olaf , Schulz Armin , J. DiSalvo Francis
Published: June 2014

Transparent, colorless crystals of the title compound are prepared by reaction of Yb2O3 and B powder in a KCl flux (Nb ampule, 1000 °C, 24 h).
ChemInform Abstract: The Silicides YT2Si2 (T: Co, Ni, Cu, Ru, Rh, Pd): A Systematic Study by 89Y Solid‐State NMR Spectroscopy.
Authors: Hoeting Christoph , Eckert Hellmut , Matar Samir F. , Rodewald Ute Ch. , Poettgen Rainer
Published: June 2014

The title compounds are prepared from the elements by arc‐melting and characterized by powder and single crystal XRD, 89Y solid state NMR spectroscopy, and DFT calculations.
ChemInform Abstract: A Novel Aluminium—Air Secondary Battery with Long‐Term Stability.
Authors: Mori Ryohei
Published: June 2014

A new Al—air cell with the structure Al/Al2(WO4)3/NaCl/Al2 (WO4)3/air cathode functions for about one month.
ChemInform Abstract: Effect of Calcination Temperature of Size Controlled Microstructure of LiNi0.8Co0.15Al0.05O2 Cathode for Rechargeable Lithium Battery.
Authors: Park Tae‐Jun , Lim Jung‐Bin , Son Jong‐Tae
Published: June 2014

Size controlled LiNi0.8Co0.15Al0.05O2 cathode powders are prepared by co‐precipitation followed by calcination between 750 and 850 °C.
ChemInform Abstract: A Novel AgIO4 Semiconductor with Ultrahigh Activity in Photodegradation of Organic Dyes: Insights into the Photosensitization Mechanism.
Authors: Tang Jianting , Li Datang , Feng Zhaoxia , Tan Zhen , Ou Baoli
Published: June 2014

Semiconducting AgIO4 is precipitated from an aqueous KIO4 solution by addition of AgNO3.
ChemInform Abstract: Crystallization of MIGe2(PO4)3 (MI: Na, K, Ag) from Molten Phosphate Media.
Authors: Terebilenko K. V. , Slobodyanik N. S. , Ogorodnyk I. V. , Baumer V. N.
Published: June 2014

The solubility isotherms for GeO2 in molten mixtures of (NH4)H2PO4 and M2CO3 (M: Na, K) at 1123 K for sodium and 1173 K for potassium are constructed and used for the preparation of the NASICON‐related title compounds.
ChemInform Abstract: Th(VO3)2(SeO3) and Ln(VO3)2(IO3) (Ln = Ce, Pr, Nd, Sm, and Eu): Unusual Cases of Aliovalent Substitution.
Authors: Eaton Teresa , Lin Jian , Cross Justin N. , Stritzinger Jared T. , Albrecht‐Schmitt Thomas E.
Published: June 2014

Th(VO3)2(SeO3) and Ln(VO3)2(IO3) (Ln: Ce, Pr, Nd, Sm, and Eu) are prepared by hydrothermal synthesis using Th and Ln nitrates, V2O5, SeO2, I2O5, and H2O (autoclave, 230 (for Th) or 180 °C (for Ln), 3 d, 60% yield for the Th compound, 40, 55, and 40% for the Ce, Pr, Eu compounds, and 5, 10% for the Nd and Sm compound).
ChemInform Abstract: K6[Fe8.27(HPO3)12]: A New Mixed‐Valence Iron Phosphite.
Authors: Hamchaoui Farida , Alonzo Veronique , Rebbah Houria , Le Fur Eric
Published: June 2014

The title compound is prepared by hydrothermal synthesis using FeSO4, H3PO3, K2CO3, and H2O in a 0.2:1.5:0.8:28 molar ratio (autoclave, 453 K, 72 h).
ChemInform Abstract: Role of Additives in Chiral Amine‐Catalyzed Direct Aldol Reaction.
Authors: Sutar R. L. , Joshi N. N.
Published: June 2014

High diastereoselectivities in direct aldol reactions can be achieved even in pyrrolidine‐catalyzed reactions.
ChemInform Abstract: Highly Enantioselective Synthesis of α‐Azido‐β‐hydroxy Methyl Ketones Catalyzed by a Cooperative Proline—Guanidinium Salt System.
Authors: Martinez‐Castaneda Angel , Kedziora Kinga , Lavandera Ivan , Rodriguez‐Solla Humberto , Concellon Carmen , del Amo Vicente
Published: June 2014

The first enantioselective synthesis of α‐azido‐β‐hydroxy ketones via direct intermolecular aldol reaction of azidoacetone and aromatic aldehydes is described.
ChemInform Abstract: Pd‐Catalyzed Kinetic Resolution of Cyclic Enol Ethers. An Enantioselective Route to Functionalized Pyrans.
Authors: Zirimwabagabo Jean‐Olivier , Harrity Joseph P. A.
Published: June 2014

The asymmetric Pd‐catalyzed [1,3]‐rearrangement of racemic cyclic enol ether (I) leads to enantioenriched cyclohexanone (II) and enantiopure enol ethers (I) (15 examples for analogues).
ChemInform Abstract: Chiral Amides via Copper‐Catalyzed Enantioselective Conjugate Addition.
Authors: Schoonen Anne K. , Fernandez‐Ibanez M. Angeles , Fananas‐Mastral Martin , Teichert Johannes F. , Feringa Ben L.
Published: June 2014

A highly enantioselective one pot procedure for the synthesis of β‐substituted amides (IV) is developed starting from the corresponding α,β‐unsaturated esters (I).
ChemInform Abstract: Organocatalysis of Nucleophilic Substitution Reactions by the Combined Effects of Two Promoters Fused in a Molecule: Oligoethylene Glycol Substituted Imidazolium Salts.
Authors: Jadhav Vinod H. , Kim Ju‐Young , Chi Dae Yoon , Lee Sungyul , Kim Dong Wook
Published: June 2014

A highly efficient promoter for the SN2 reaction of various substrates by enhancing the reactivity of alkali metal salts is presented.
ChemInform Abstract: Expedient Synthesis of C3‐Symmetric Hexasubstituted Benzenes via Nicholas Reaction/[2 + 2 + 2] Cycloaddition. New Platforms for Molecular Recognition.
Authors: Carrillo Romen , Martin Tomas , Lopez‐Rodriguez Matias , Pinacho Crisostomo Fernando
Published: June 2014

The new method is based on the Nicholas reaction giving dimer (II) and macrocycle (III) which is further converted into the target compound by decomplexation and [2 + 2 + 2] cycloaddition under microwave irradiation.
ChemInform Abstract: Solvent Free Nucleophilic Introduction of Fluorine with [bmim][F].
Authors: Bouvet Sebastien , Pegot Bruce , Marrot Jerome , Magnier Emmanuel
Published: June 2014

An improved synthesis as well as a recycling procedure for [bmim]F is presented.
ChemInform Abstract: A General Method for N‐Methylation of Amines and Nitro Compounds with Dimethylsulfoxide.
Authors: Jiang Xue , Wang Chao , Wei Yawen , Xue Dong , Liu Zhaotie , Xiao Jianliang
Published: June 2014

A novel, green, and practical method for the amine methylation is developed.
ChemInform Abstract: nBu4NI‐Catalyzed Oxidative Imidation of Ketones with Imides: Synthesis of α‐Amino Ketones.
Authors: Lv Yunhe , Li Yan , Xiong Tao , Lu Yu , Liu Qun , Zhang Qian
Published: June 2014

The first example of a Bu4NI‐catalyzed C—N cross‐coupling imidation reaction of sp3 C—H bonds in imides with TBHP as oxidant is reported.
ChemInform Abstract: One‐Pot, Two‐Step Direct Conversion of Alkenes to Amines Through Tandem Ozonolysis and Ammonia‐Borane in Water.
Authors: Tyagi Vipin , Gupta Ashok Kumar
Published: June 2014

A simple, mild, and efficient one‐pot procedure for the conversion of alkenes to amines in environmentally friendly aqueous solution is developed.
ChemInform Abstract: Silica‐Functionalized CuI: An Efficient and Selective Catalyst for N‐Benzylation, Allylation, and Alkylation of Primary and Secondary Amines in Water.
Authors: Shamim Tahira , Kumar Vineet , Paul Satya
Published: June 2014

The employed catalyst can be recycled and reused for up to five runs without loss of activity.
ChemInform Abstract: Phosphane‐Ligated Ionic Palladium Complexes: Synthesis, Characterization and Application as Efficient and Reusable Precatalysts for the Homogeneous Carbonylative Sonogashira Reaction under CuI‐Free Conditions.
Authors: Zhang Jing , Wang Yongyong , Zhao Xiaoli , Liu Ye
Published: June 2014

The catalyst can be recycled and reused for 5 runs without a significant loss of activity.
ChemInform Abstract: Amides in One Pot from Carboxylic Acids and Amines via Sulfinylamides.
Authors: Bai Jianfei , Zambron Bartosz K. , Vogel Pierre
Published: June 2014

This efficient method is applicable to primary and secondary amines, including the tert‐butyl esters of α‐amino acids.
ChemInform Abstract: Reductive Removal of Methoxyacetyl Protective Group Using Sodium Borohydride.
Authors: Gadekar Pradip K. , Hoermann Maryann , Corbo Faith , Sharma Rajiv , Sarveswari S. , Roychowdhury Abhijit
Published: June 2014

A selective reductive deprotection of methoxyacetyl‐protected alcohols and thiols is presented.
ChemInform Abstract: A New Gold‐Catalyzed Azidation of Allenes.
Authors: Hurtado‐Rodrigo Cesar , Hoehne Stefanie , Munoz Maria Paz
Published: June 2014

This highly modular gold‐catalyzed reaction fails for allenes containing acid sensitive functional groups.
ChemInform Abstract: Asymmetric Reduction of Diynones and the Total Synthesis of (S)‐Panaxjapyne A.
Authors: Fang Zhijia , Wills Martin
Published: June 2014

This asymmetric transfer hydrogenation is efficiently applied to the total synthesis of the cytotoxic natural product (S)‐panaxjapyne A (V).
ChemInform Abstract: A Convenient Regioselective Synthesis of Cyclopentadienones via Palladium‐Catalyzed [2 + 2 + 1] Cyclocarbonylation of Alkynes.
Authors: Xu Yanli , Zhao Jinwu , Chen Huoji , Wu Wanqing , Jiang Huanfeng
Published: June 2014

The analogues reaction of 1,2‐diphenylethyne (VII) with 4‐phenylbut‐3‐yn‐2‐one, 3‐phenylpropiolaldehyde, 3‐phenylpropiolic acid or 3‐phenylpropiolamide gave none or only trace amounts of the desired products.
ChemInform Abstract: Rh(III)‐Catalyzed C—H Activation with Allenes to Synthesize Conjugated Olefins.
Authors: Gong Tian‐Jun , Su Wei , Liu Zhao‐Jing , Cheng Wan‐Min , Xiao Bin , Fu Yao
Published: June 2014

The Rh(III)‐catalyzed C—H activation with allenes is applicable to olefin and arene C(sp2)—H bonds and is compatible to a variety of functional groups.
ChemInform Abstract: Chemoselective N‐Deacetylation under Mild Conditions.
Authors: Sultane Prakash R. , Mete Trimbak B. , Bhat Ramakrishna G.
Published: June 2014

Competition experiments between N‐acetyl protected 4‐methoxyaniline and N‐Cbz‐, N‐Boc‐, N‐Fmoc‐ or N‐Tos‐protected aniline, respectively, lead to chemoselective deacetylation of 4‐methoxyaniline and almost quantitative recovery of the competitive substrates.
ChemInform Abstract: Chemoselective Hydrogenation of Functionalized Nitroarenes and Imines by Using Carbon Nanofiber‐Supported Iridium Nanoparticles.
Authors: Motoyama Yukihiro , Taguchi Masahiro , Desmira Nelfa , Yoon Seong‐Ho , Mochida Isao , Nagashima Hideo
Published: June 2014

The catalyst consisting of carbon nanofibers with tubular graphite layers is reused five times without loss of activity.
ChemInform Abstract: Iridium‐Catalyzed Selective α‐Methylation of Ketones with Methanol.
Authors: Ogawa Shinji , Obora Yasushi
Published: June 2014

Diminishing the catalyst loading from 5 mol% to 0.5 mol% decreases the yield of product (IIIa) only slightly.
ChemInform Abstract: Transformylating Amine with DMF to Formamide over CeO2 Catalyst.
Authors: Wang Yehong , Wang Feng , Zhang Chaofeng , Zhang Jian , Li Mingrun , Xu Jie
Published: June 2014

The acid‐base bifunctional property of the heterogeneous catalyst CeO2 is crucial and it is the only heterogeneous catalytic system reported to accomplish this reaction in good yields.
ChemInform Abstract: Formylation of Amines Through Catalyst‐ and Solvent‐Free Transamidation Reaction.
Authors: Lebleu Thomas , Kotsuki Hiyoshizo , Maddaluno Jacques , Legros Julien
Published: June 2014

Green and neutral conditions for the title reaction are reported.
ChemInform Abstract: Palladium‐Catalyzed Regio‐ and Stereoselective Chlorothiolation of Terminal Alkynes with Sulfenyl Chlorides.
Authors: Iwasaki Masayuki , Fujii Tomoya , Yamamoto Arisa , Nakajima Kiyohiko , Nishihara Yasushi
Published: June 2014

The reaction proceeds with complete (Z)‐selectivity.
ChemInform Abstract: Copper‐Catalyzed C—H Bond Direct Chalcogenation of Aromatic Compounds Leading to Diaryl Sulfides, Selenides, and Diselenides by Using Elemental Sulfur and Selenium as Chalcogen Sources under Oxidative Conditions.
Authors: Shibahara Fumitoshi , Kanai Takafumi , Yamaguchi Eiji , Kamei Akika , Yamauchi Takayuki , Murai Toshiaki
Published: June 2014

An oxidative Cu‐catalyzed chalcogenation of aromatic compounds with elemental sulfur or selenium and air or oxygen as terminal oxidant is presented.
ChemInform Abstract: Base‐Mediated Synthesis of 1‐Aryl‐4‐(phenylsulfonyl)butan‐1‐ones from 1,2‐Bis(phenylsulfonyl)ethane and Ketones.
Authors: Xie Ye‐Xiang , Song Ren‐Jie , Liu Yu , Wang Zhi‐Qiang , Xiang Jian‐Nan , Li Jin‐Heng
Published: June 2014

This new and simple process gives access to primary sulfones by using 1,2‐bis(phenylsulfonyl)ethane as the sulfone source, for the first time.
ChemInform Abstract: AMVN‐Initiated Expedient Synthesis of Biaryls by the Coupling Reaction of Unactivated Arenes and Heteroarenes with Aryl Iodides
Authors: Bhakuni Bhagat Singh , Yadav Abhimanyu , Kumar Shailesh , Kumar Sangit
Published: June 2014

33 examples
ChemInform Abstract: Fe(OTf)3‐Catalyzed α‐Benzylation of Aryl Methyl Ketones with Electrophilic Secondary and Aryl Alcohols.
Authors: Pan Xiaojuan , Li Minghao , Gu Yanlong
Published: June 2014

Aryl methyl ketones can be used as nucleophiles in Fe(OTf)3‐catalyzed Friedel‐Crafts type reactions with benzhydrols to form the corresponding products (III) in good yields.
ChemInform Abstract: Expedient Access to Substituted 3‐Amino‐2‐cyclopentenones by Dirhodium‐Catalyzed [3 + 2]‐Annulation of Silylated Ketene Imines and Enoldiazoacetates.
Authors: Xu Xichen , Leszczynski John S. , Mason Savannah M. , Zavalij Peter Y. , Doyle Michael P.
Published: June 2014

The reaction of (I) to (IIIa) is scaled up.
ChemInform Abstract: Pictet—Spengler Reactions of Oxetan‐3‐ones and Related Heterocycles.
Authors: Beasley Benjamin O. , Alli‐Balogun Abimbola , Clarkson Guy J. , Shipman Michael
Published: June 2014

Pictet—Spengler cyclizations of 3‐oxetan‐3‐one or azetidin‐3‐one with tryptamine or tryptophan derivatives gives spirocyclic tetrahydro‐β‐carbolines.
ChemInform Abstract: Acyl Migration from N to C in Aziridine‐2‐carboxylic Esters.
Authors: Strumfs Boriss , Hermane Jekaterina , Belyakov Sergey , Trapencieris Peteris
Published: June 2014

The substituent in the ester group at the C2 position strongly influences the yields of the migration products.
ChemInform Abstract: Direct Access to Isoindolines Through Tandem Rh(III)‐Catalyzed Alkenylation and Cyclization of N‐Benzyltriflamides.
Authors: Mishra Neeraj Kumar , Park Jihye , Sharma Satyasheel , Han Sangil , Kim Mirim , Shin Youngmi , Jang Jinbong , Kwak Jong Hwan , Jung Young Hoon , Kim In Su
Published: June 2014

Title compounds (III), (V), and (X) are prepared via Rh‐catalyzed C—H bond functionalization directed by a triflamide moiety, followed by an intramolecular aza‐Mannich cyclization.
ChemInform Abstract: Enantioselective Construction of Vicinal All‐Carbon Quaternary Centers via Catalytic Double Asymmetric Decarboxylative Allylation.
Authors: Ghosh Santanu , Bhunia Subhajit , Kakde Badrinath N. , De Subhadip , Bisai Alakesh
Published: June 2014

The decarboxylation product (IIb) is a building block for the preparation of alkaloids like (‐)‐chimonanthine, (+)‐calycanthine, ent‐WIN 64821 and (‐)‐ditryptophenline.
ChemInform Abstract: Syntheses of 4‐, 5‐, 6‐, and 7‐Substituted Tryptamine Derivatives and the Use of a Bromine Atom as a Protecting Group.
Authors: Rene Olivier , Fauber Benjamin P.
Published: June 2014

The title compounds are prepared from chlorophenylhydrazines and 5‐chloropentan‐2‐one.
ChemInform Abstract: Enantioselective Hydroacylation of N‐Vinylindole‐2‐carboxaldehydes.
Authors: Ghosh Avipsa , Stanley Levi M.
Published: June 2014

A rhodium‐catalyzed intramolecular hydroacylation of aldehydes (I) leads to chiral tricyclic indoles (II) with high enantioselectivity.
ChemInform Abstract: Regioselective Functionalization of the Oxazole Scaffold Using TMP‐Bases of Mg and Zn.
Authors: Haas Diana , Mosrin Marc , Knochel Paul
Published: June 2014

This new and general method allows the construction of oxazole derivatives with up to three different substituents.
ChemInform Abstract: Hypervalent Iodine‐Catalyzed Cycloaddition of Nitrile Oxides to Alkenes
Authors: Xiang Changbin , Li Tingting , Yan Jie
Published: June 2014

as a new and convenient procedure for the synthesis of isoxazolines
ChemInform Abstract: KI‐Catalyzed Arylation of Benzothiazoles from the Coupling of Aryl Aldehydes with Benzothiazoles in Neat Water.
Authors: Gao Yuyu , Song Qiuling , Cheng Guolin , Cui Xiuling
Published: June 2014

A series of 2‐substituted benzothiazoles (III) and (V) (28 examples in all) is readily prepared by a KI‐catalyzed oxidative arylation of benzothiazoles (I) with corresponding aldehydes (II) and (IV), respectively.
ChemInform Abstract: Rhodium‐Catalyzed Intermolecular Hydroarylation of Internal Alkynes with N‐1‐Phenylbenzotriazoles.
Authors: Zhou Wang , Yang Youqing , Wang Zhiwei , Deng Guo‐Jun
Published: June 2014

Attempts towards performing the reaction using 1‐phenyl‐indole or 1‐phenyl‐1,3‐benzodiazole instead of the 1‐phenyl‐1,2,3‐benzotriazole derivatives fail.
ChemInform Abstract: An Asymmetric Iodolactonization Reaction Catalyzed by a Zinc Bis‐proline—Phenol Complex.
Authors: Filippova Liudmila , Stenstroem Yngve , Hansen Trond Vidar
Published: June 2014

The application of Trost′s di‐nuclear zinc complex in catalytic asymmetric iodocyclizations of 5‐substituted 5‐hexenoic acid derivatives using NIS is demonstrated.
ChemInform Abstract: From Liquid to Solid‐State Fluorescence: Tricyclic Lactones Based on 4‐Hydroxy‐1,3‐thiazoles.
Authors: Calderon Ortiz Lorena K. , Wuerfel Hendryk , Taeuscher Eric , Weiss Dieter , Birckner Eckhard , Goerls Helmar , Beckert Rainer
Published: June 2014

The compounds′ fluorescence properties in solid state as well as in polar solvents (EtOH, DMSO) in absence and presence of NaOH and HCl are examined.
ChemInform Abstract: Efficient and Scalable Synthesis of 4‐Carboxy‐Pennsylvania Green Methyl Ester: A Hydrophobic Building Block for Fluorescent Molecular Probes.
Authors: Woydziak Zachary R. , Fu Liqiang , Peterson Blake
Published: June 2014

The improved reaction conditions allow the synthesis of multigram quantities of the title compound (VIII) in 28% overall yield.
ChemInform Abstract: Solvent‐Free Microwave‐Assisted Preparation of N‐(2‐(Pyridin‐2‐yl)‐ethyl)sulfonamides
Authors: Ghattas Paul , Carlin Joseph W. , Murkli Steven L. , Jacobs Danielle L.
Published: June 2014

via 1,4‐aza‐conjugate addition between sulfonamides and 2‐vinylpyridine
ChemInform Abstract: Comparative Study of Catalytic Potential of TBAB, BTEAC, and CTAB in One‐Pot Synthesis of 1,4‐Dihydropyridines under Aqueous Medium.
Authors: Ananda Kumar T. Durai , Mohan P. , Subrahmanyam C. V. S. , Satyanarayana K.
Published: June 2014

Efficient synthesis of 1,4‐dihydropyridines via phase‐transfer catalyzed Hantzsch reactions are described.
ChemInform Abstract: A Cascade Cross‐Coupling Hydrogen Evolution Reaction by Visible Light Catalysis.
Authors: Wu Li‐Zhu , et al. et al.
Published: June 2014

The first example of a photocatalytic dehydrative cross‐coupling reaction employing two different C‐H bonds is described.
ChemInform Abstract: Diastereoselective Synthesis of Highly Functionalized Quinolizines via a Pyridine‐Based Three‐Component Reaction and a DFT Investigation on the Reaction Mechanism.
Authors: Esmaeili Abbas Ali , Zarifi Farzaneh , Moradi Abbas , Izadyar Mohammad , Fakhari Ali Reza
Published: June 2014

This novel, one‐pot, three‐component reaction affords quinolizine derivatives via 1,4‐dipolar cycloaddition without using any catalyst or activation.
ChemInform Abstract: The Acid‐Catalyzed Synthesis of 7‐Azaindoles from 3‐Alkynyl‐2‐aminopyridines and Their Antimicrobial Activity.
Authors: Leboho Tlabo C. , van Vuuren Sandy F. , Michael Joseph P. , de Koning Charles B.
Published: June 2014

A series of 7‐azaindoles is prepared by Sonogashira coupling of 3‐halopyridines (I) with alkynes followed by ring‐closure reaction of resulting 3‐alkynyl‐2‐aminopyridines (III) in the presence of TFA and TFAA.
ChemInform Abstract: Simple, Multicomponent, Ecofriendly, Microwave‐Mediated Route for the Synthesis of Antimicrobial 2‐Amino‐6‐aryl‐4‐(3H)‐pyrimidinones.
Authors: da Silva Ivangela E. A. , Braga Vanildo M. L. , Melo Mychely S. , dos S. Correia Maria Tereza , dos Anjos Janaina V.
Published: June 2014

Pyrimidinones (IVa) and (IVf) show significant activity against S.
ChemInform Abstract: Synthesis of 4‐Unsubstituted Dihydropyrimidines Having Acyl and Alkoxycarbonyl Groups at 5‐ and 6‐Positions by Cyclization—Elimination Reactions Using 1,3‐Diaza‐1,3‐butadienes.
Authors: Nishimura Yoshio , Cho Hidetsura
Published: June 2014

The reaction of 1,2‐disubstituted ethylenes with diazabutadiene (II) and subsequent elimination of a dimethylamino group gives access to novel N‐Boc protected dihydropyrimidines.
ChemInform Abstract: Design, Synthesis, and Antibacterial Evaluation of Some Novel 3′‐(Phenylamino)‐1′H‐spiro[indoline‐3,2′‐quinazoline]‐2,4′(3′H)‐dione Derivatives.
Authors: Mohammadi Ali A. , Askari Saber , Rohi Hamed , Soorki Ali Abolhasani
Published: June 2014

A variety of new spiro(indoline‐quinazoline) derivatives (IV) (13 examples) are synthesized via an efficient one‐pot, three‐component reaction of isatins, isatoic anhydrides, and phenylhydrazine using alum as a nontoxic, easily available catalyst.
ChemInform Abstract: A Novel and Effective Approach to 4‐Fluoropyrimidines.
Authors: Sedenkova Kseniya N. , Averina Elena B. , Grishin Yuri K. , Kuznetsova Tamara S. , Zefirov Nikolay S.
Published: June 2014

It is demonstrated, that 4‐fluoropyrimidines can be synthesized in a two‐step process involving heterocyclization of gem‐bromofluorocyclopropanes followed by reduction of the resulting N‐oxides with PCl3.
ChemInform Abstract: C—S Bond‐Forming Reactions of Barbiturylbromide with Isothiocarbamides in Aqueous Media.
Authors: Sontakke Madhuri M. , Jichkar Atul A. , Dhonde Madhukar G. , Bhaskar Chandrakant S. , Berad Baliram N.
Published: June 2014

The C—S cross‐coupling proceeds without any catalyst, is very efficient, simple, general, and high yielding.
ChemInform Abstract: Synthesis of Bisindolylindeno[1,2‐b]quinoxaline and Bisindolylindeno[3,4‐b]pyrazine with Poly(N,N′‐dibromo‐N‐ethylnaphthyl‐2,7‐disulfonamide).
Authors: Khazaei Ardeshir , Massoudi Abdolhossien , Chegeni Mahdieh
Published: June 2014

A simple and efficient method for the synthesis of the new title compounds [cf.
ChemInform Abstract: A Novel Protocol for Selective Synthesis of Monoclinic Zirconia Nanoparticles as a Heterogeneous Catalyst for Condensation of 1,2‐Diamines with 1,2‐Dicarbonyl Compounds.
Authors: Jafarpour Maasoumeh , Rezapour Elham , Ghahramaninezhad Mahboobe , Rezaeifard Abdolreza
Published: June 2014

Monoclinic zirconia nanoparticles efficiently catalyze the condensation of various 1,2‐diamines with 1,2‐dicarbonyl compounds to provide an environmentally friendly alternative for the synthesis of quinoxaline and pyridopyrazine derivatives.
ChemInform Abstract: Expeditious Synthesis of C2‐ or N4‐Aryl‐1,4‐benzothiazin‐3‐one via Orthogonal Pd‐Catalyzed C‐Arylation and Cu‐Catalyzed N‐Arylation.
Authors: Huang Wei‐Sheng , Xu Rongsong , Dodd Rory , Shakespeare William C.
Published: June 2014

Efficient reaction conditions for the regioselective N‐arylation as well as the regioselective C2‐arylation of 1,4‐benzothiazin‐3‐one are presented.
ChemInform Abstract: Microwave Assisted Synthesis of 10b‐Aza‐10c‐borapyrene.
Authors: Wadle Jonathan J. , McDermott Logan B. , Fort Eric H.
Published: June 2014

The microwave assisted reaction allows the synthesis of the title compound in reduced time and with simplified reaction conditions.
ChemInform Abstract: Stereoselective Synthesis of Either (E)‐ or (Z)‐Silyl Enol Ether from the Same Acyclic α,β‐Unsaturated Ketone Using Cationic Rhodium Complex‐Catalyzed 1,4‐Hydrosilylation.
Authors: Onodera Gen , Hachisuka Ryosuke , Noguchi Tomomi , Miura Hiroki , Hashimoto Toru , Takeuchi Ryo
Published: June 2014

Silyl enol ethers are prepared by Rh‐catalyzed 1,4 hydrosilylation of α,β‐unsaturated ketones.
ChemInform Abstract: Highly Efficient One‐Pot Synthesis of α‐Aminophosphonates Catalyzed by Ytterbium Triflate in Water.
Authors: Shen MingGui , Shang ShiBin , Song ZhanQian , Wang Dan , Rao XiaoPing , Gao Hong , Wang Juan
Published: June 2014

A highly efficient protocol for the synthesis of α‐aminophosphonates (IV) (15 examples) via three‐component, one‐pot reaction of aldehydes, primary amines, and diethyl phosphite is developed.
ChemInform Abstract: An Expedient Synthesis of Pyrrole‐2‐phosphonates via Direct Oxidative Phosphorylation and γ‐Hydroxy‐γ‐butyrolactams from Pyrroles.
Authors: Kim Se Hee , Kim Ko Hoon , Lim Jin Woo , Kim Jae Nyoung
Published: June 2014

A convenient protocol for the synthesis of pyrrole‐2‐phosphonates via Ag‐catalyzed reaction of dialkyl phosphites with pyrrole is developed.
ChemInform Abstract: Four New 7,8‐Epoxycembranoids from a Chinese Soft Coral Lobophytum sp.
Authors: Zhao Min , Li Xiubao , Zhao Feng , Cheng Shimiao , Xiang Zheng , Dong Jianyong , Huang Kexin , Yan Pengcheng
Published: June 2014

isolation, structural elucidation and inhibitory effect on lipopolysaccharide (LPS)‐induced nitric oxide (NO) production in mouse peritoneal macrophages
ChemInform Abstract: Regioselective One‐Pot Protection, Protection—Glycosylation and Protection—Glycosylation—Glycosylation of Carbohydrates: A Case Study with D‐Glucose.
Authors: Huang Teng‐Yi , Zulueta Medel Manuel L. , Hung Shang‐Cheng
Published: June 2014

The TmsOTf‐catalyzed reaction of tetrasilylated glucoside (I) with benzaldehyde leads to an intermediate benzylidene acetal diol, which is converted into triols (III) and (IV) by a reductive ring opening (11 further examples for the one‐pot protection).
ChemInform Abstract: Syntheses of 5′‐Amino‐2′,5′‐dideoxy‐2′,2′‐difluorocytidine Derivatives as Novel Anticancer Nucleoside Analogues.
Authors: Labroli Marc A. , Dwyer Michael P. , Shen Ruichao , Popovici‐Muller Janeta , Pu Qinglin , Richard Judson , Rosner Kristen , Paruch Kamil , Guzi Timothy J.
Published: June 2014

A series of 5′‐amino derivatives of gemcitabine are synthesized in order to identify anticancer nucleoside analogues (no biological activity reported).
ChemInform Abstract: Late‐Stage β‐Epimerization. A Stereodivergent to Stereoconvergent Relay to the First Total Synthesis of (+)‐Murolic Acid.
Authors: Fernandes Rodney A. , Patil Pradnya H. , Chowdhury Asim K.
Published: June 2014

The target compound is synthesized in 17 steps and 15% overall yield.
ChemInform Abstract: Tandyukisin, a Novel Ketoaldehyde Decalin Derivative, Produced by a Marine Sponge‐Derived Trichoderma harzianum.
Authors: Yamada Takeshi , Mizutani Yuki , Umebayashi Yoshihide , Inno Naoko , Kawashima Maiko , Kikuchi Takashi , Tanaka Reiko
Published: June 2014

The compound (I) exhibits a moderate cytotoxicity against human cancer cell lines.
ChemInform Abstract: BiVO4—Ru/SrTiO3:Rh Composite Z‐Scheme Photocatalyst for Solar Water Splitting.
Authors: Jia Qingxin , Iwase Akihide , Kudo Akihiko
Published: June 2014

A composite Z‐scheme water splitting photocatalyst that combines a H2 evolution photocatalyst (Rh‐doped Ru/SrTiO3) with an O2 evolving catalyst (BiVO4) is prepared by an impregnation method as well as a liquid—solid state reaction.
ChemInform Abstract: Understanding Boron Through Size‐Selected Clusters: Structure, Chemical Bonding, and Fluxionality
Authors: Sergeeva Alina P. , Popov Ivan A. , Piazza Zachary A. , Li Wei‐Li , Romanescu Constantin , Wang Lai‐Sheng , Boldyrev Alexander I.
Published: June 2014

Review: 88 refs.
ChemInform Abstract: Recent Advances of Doping of SnO2 Nanocrystals for Their Potential Applications
Authors: Kar Arik , Patra Amitava
Published: June 2014

Review: 88 refs.
ChemInform Abstract: New Strategies to Prepare Crystalline Chalcogenides
Authors: Xiong Wei‐Wei , Zhang Guodong , Zhang Qichun
Published: June 2014

Review: ionothermal, surfactant‐thermal, hydrazine‐thermal, and usage of metal Zintl phases; 121 refs.
ChemInform Abstract: Exploring the Limits: A Low‐Pressure, Low‐Temperature Haber—Bosch Process
Authors: Vojvodic Aleksandra , Medford Andrew James , Studt Felix , Abild‐Pedersen Frank , Khan Tuhin Suvra , Bligaard T. , Noerskov J. K.
Published: June 2014

Review: emphasis on catalyst requirements; 38 refs.
ChemInform Abstract: Metal—Metal Multiple Bonding in C3‐Symmetric Bimetallic Complexes of the First Row Transition Metals
Authors: Krogman Jeremy P. , Thomas Christine M.
Published: June 2014

Review: 101 refs.
ChemInform Abstract: Transition‐Metal‐Catalyzed Ketone‐Directed ortho‐C—H Functionalization Reactions
Authors: Zheng Qing‐Zhong , Jiao Ning
Published: June 2014

Review: [34 refs.
ChemInform Abstract: Asymmetric Synthesis Cascades of Catalytic Selectivity
Authors: Dewhurst Rian D. , Marder Todd B.
Published: June 2014

Review: 12 refs.
ChemInform Abstract: Catalytic Enantioselective 1,3‐Dipolar Cycloadditions of Azomethine Ylides for Biology‐Oriented Synthesis
Authors: Narayan Rishikesh , Potowski Marco , Jia Zhi‐Jun , Antonchick Andrey P. , Waldmann Herbert
Published: June 2014

Review: 37 refs.
ChemInform Abstract: Piperine‐Type Amides. Review of the Chemical and Biological Characteristics
Authors: Okwute Simon Koma , Egharevba Henry Omoregie
Published: June 2014

Review: 79 refs.
ChemInform Abstract: Natural Products Chemistry Research. Progress in China in 2011
Authors: Ye Yang , Li Xi‐qiang , Tang Chun‐ping , Yao Sheng
Published: June 2014

Review: 99 refs.
ChemInform Abstract: Controlling the Surface Environment of Heterogeneous Catalysts Using Self‐Assembled Monolayers
Authors: Schoenbaum Carolyn A. , Schwartz Daniel K. , Medlin J. Will
Published: June 2014

Review: 38 refs.
ChemInform Abstract: Air‐ and Moisture‐stable Amphoteric Molecules: Enabling Reagents in Synthesis
Authors: He Zhi , Zajdlik Adam , Yudin Andrei K.
Published: June 2014

Review: 51 refs.
ChemInform Abstract: The [3 + 3]‐Cycloaddition Alternative for Heterocycle Syntheses: Catalytically Generated Metalloenolcarbenes as Dipolar Adducts
Authors: Xu Xinfang , Doyle Michael P.
Published: June 2014

Review: 91 refs.
ChemInform Abstract: The Synthetic Development of Pyrazole Nucleus: From Reflux to Microwave
Authors: Arora Harish K. , Jain Sandeep
Published: June 2014

Review: 51 refs.
ChemInform Abstract: Review of Synthesis of Multispiro Heterocyclic Compounds from Isatin
Authors: Borad Mayuri A. , Bhoi Manoj N. , Prajapati Neelam P. , Patel Hitesh D.
Published: June 2014

Review: 67 refs.
ChemInform Abstract: Recent Progress on Asymmetric Organocatalytic Construction of Chiral Cyclohexenone Skeletons
Authors: Yang Xin , Wang Jun , Li Pengfei
Published: June 2014

Review: 64 refs.
ChemInform Abstract: Preparation and Synthetic Applications of Trivalent Arylbismuth Compounds as Arylating Reagents. A Review
Authors: Condon Sylvie , Pichon Christophe , Davi Michael
Published: June 2014

Review: 131 refs.
ChemInform Abstract: Artemisinin: A Case Study in the Evolution of Synthetic Strategy
Authors: Cook Silas P.
Published: June 2014

Review: [35 refs.
ChemInform Abstract: Microbial Terpenes: A Perspective on Their Chemistry and Biosynthesis
Authors: Citron Christian A. , Dickschat Jeroen S.
Published: June 2014

Review: [164 refs.
ChemInform Abstract: The Anion‐Binding Approach to Catalytic Enantioselective Acyl Transfer
Authors: Seidel Daniel
Published: June 2014

Review: [42 refs.
ChemInform Abstract: Synergistic—Cooperative Combination of Enamine Catalysis with Transition Metal Catalysis
Authors: Deng Yongming , Kumar Siddhartha , Wang Hong
Published: June 2014

Review: 83 refs.
ChemInform Abstract: The Nef Reaction of Isocyanides
Authors: La Spisa Fabio , Tron Gian Cesare , El Kaim Laurent
Published: June 2014

Review: [58 refs.
ChemInform Abstract: 1,4‐Dipolar Cycloadditions and Related Reactions
Authors: Nair Vijay , Deepthi Ani , Ashok Devipriya , Raveendran Anabha E. , Paul Rony Rajan
Published: June 2014

Review: [86 refs.
ChemInform Abstract: Synthesis and Biological Activities of Simplified Analogues of the Natural PKC Ligands, Bryostatin‐1 and Aplysiatoxin
Authors: Irie Kazuhiro , Yanagita Ryo C.
Published: June 2014

Review: [80 refs.
ChemInform Abstract: Endeavors to Access Molecular Complexity: Strategic Use of Free Radicals in Natural Product Synthesis
Authors: Yoshimitsu Takehiko
Published: June 2014

Review: [60 refs.
ChemInform Abstract: Gold‐Catalyzed Cascade Reactions for Synthesis of Carbo‐ and Heterocycles: Selectivity and Diversity
Authors: Qian Deyun , Zhang Junliang
Published: June 2014

Review: [32 refs.
ChemInform Abstract: Hydrogen‐Bonding Organocatalysts for Ring‐Opening Polymerization
Authors: Thomas Coralie , Bibal Brigitte
Published: June 2014

Review: [77 refs.
ChemInform Abstract: Diversification in the Synthesis of Antimalarial Trioxane and Tetraoxane Analogues
Authors: Yadav Neesha , Sharma Chiranjeev , Awasthi Satish Kumar
Published: June 2014

Review: 180 refs.
ChemInform Abstract: Advancement in Cascade [1,n]‐Hydrogen Transfer/Cyclization: A Method for Direct Functionalization of Inactive C(sp3)—H Bonds
Authors: Wang Liang , Xiao Jian
Published: June 2014

Review: [58 refs.