bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure Legends from Neuropilin-2 Regulates Endosome Maturation and EGFR Trafficking to Support Cancer Cell Pathobiology
Authors: Dutta Samikshan , Roy Sohini , Polavaram Navatha S. , Stanton Marissa J. , Zhang Heyu , Bhola Tanvi , Hönscheid Pia , Donohue Terrence M. , Band Hamid , Batra Surinder K. , Muders Michael H. , Datta Kaustubh
Published: March 2023

Supplementary figure legends
Supplementary Figure Legends from Eva1 Maintains the Stem-like Character of Glioblastoma-Initiating Cells by Activating the Noncanonical NF-κB Signaling Pathway
Authors: Ohtsu Naoki , Nakatani Yuka , Yamashita Daisuke , Ohue Shiro , Ohnishi Takanori , Kondo Toru
Published: March 2023

Legends for Supplementary Figures S1-S9.
Supplementary methods from Rapalogs Efficacy Relies on the Modulation of Antitumor T-cell Immunity
Authors: Beziaud Laurent , Mansi Laura , Ravel Patrice , Marie-Joseph Elodie Lauret , Laheurte Caroline , Rangan Laurie , Bonnefoy Francis , Pallandre Jean-René , Boullerot Laura , Gamonet Clémentine , Vrecko Sindy , Queiroz Lise , Maurina Tristan , Mouillet Guillaume , Hon Thierry Nguyen Tan , Curtit Elsa , Royer Bernard , Gaugler Béatrice , Bayry Jagadeesh , Tartour Eric , Thiery-Vuillemin Antoine , Pivot Xavier , Borg Christophe , Godet Yann , Adotévi Olivier
Published: March 2023

This file contains the supplementary material and methods
Supplementary Fig 1 from Neuropilin-2 Regulates Endosome Maturation and EGFR Trafficking to Support Cancer Cell Pathobiology
Authors: Dutta Samikshan , Roy Sohini , Polavaram Navatha S. , Stanton Marissa J. , Zhang Heyu , Bhola Tanvi , Hönscheid Pia , Donohue Terrence M. , Band Hamid , Batra Surinder K. , Muders Michael H. , Datta Kaustubh
Published: March 2023

The depletion of NRP2 inhibits Rab switch that lead to an accumulation of immature autophagosome and early endosome
Supplementary Figure S3 from Upregulation of Cytosolic Phosphoenolpyruvate Carboxykinase Is a Critical Metabolic Event in Melanoma Cells That Repopulate Tumors
Authors: Li Yong , Luo Shunqun , Ma Ruihua , Liu Jing , Xu Pingwei , Zhang Huafeng , Tang Ke , Ma Jingwei , Zhang Yi , Liang Xiaoyu , Sun Yanling , Ji Tiantian , Wang Ning , Huang Bo
Published: March 2023

Supplementary Figure S3. Fructose-1,6-bisphosphatase (FBP1) and glucose-6- phosphatase (G6Pase) were not expressed in B16 TRCs and PCK1 knockdown had no effect on glucose transporter 1 (GLUT1) expression and membrane localization.
Supplemental Data from Multinucleation and Mesenchymal-to-Epithelial Transition Alleviate Resistance to Combined Cabazitaxel and Antiandrogen Therapy in Advanced Prostate Cancer
Authors: Martin Sarah K. , Pu Hong , Penticuff Justin C. , Cao Zheng , Horbinski Craig , Kyprianou Natasha
Published: March 2023

Legends for supplemental figures
Supplementary Tables S1-S4 from The Proliferative Activity of Mammary Epithelial Cells in Normal Tissue Predicts Breast Cancer Risk in Premenopausal Women
Authors: Huh Sung Jin , Oh Hannah , Peterson Michael A. , Almendro Vanessa , Hu Rong , Bowden Michaela , Lis Rosina L. , Cotter Maura B. , Loda Massimo , Barry William T. , Polyak Kornelia , Tamimi Rulla M.
Published: March 2023

The percentage of p27+ cells by breast tissue type (S1); The percentage of ER+ cells by breast tissue type (S2); The percentage of Ki67+ cells by breast tissue type (S3); Spearman correlations between markers in normal breast tissue in the Nurses' Health Study and the Nurses' Health Study II (S4).
Supplementary Figures S1-S2 from The Proliferative Activity of Mammary Epithelial Cells in Normal Tissue Predicts Breast Cancer Risk in Premenopausal Women
Authors: Huh Sung Jin , Oh Hannah , Peterson Michael A. , Almendro Vanessa , Hu Rong , Bowden Michaela , Lis Rosina L. , Cotter Maura B. , Loda Massimo , Barry William T. , Polyak Kornelia , Tamimi Rulla M.
Published: March 2023

Image analysis of benign breast lesions (S1); Boxplots of the percentage of p27+, ER+, and Ki67+ cells in benign breast lesions (S2).
Supplementary Materials and Methods, Supplementary Tables 1 and 2, and Supplementary Figures 1 through 3 from Deguelin Analogue SH-1242 Inhibits Hsp90 Activity and Exerts Potent Anticancer Efficacy with Limited Neurotoxicity
Authors: Lee Su-Chan , Min Hye-Young , Choi Hoon , Bae Song Yi , Park Kwan Hee , Hyun Seung Yeob , Lee Ho Jin , Moon Jayoung , Park Shin-Hyung , Kim Jun Yong , An Hongchan , Park So-Jung , Seo Ji Hae , Lee Seungbeom , Kim Young-Myeong , Park Hyun-Ju , Lee Sang Kook , Lee Jeewoo , Lee Jeeyeon , Kim Kyu-Won , Suh Young-Ger , Lee Ho-Young
Published: March 2023

Supplementary Materials and Methods. Supplementary Table 1. The acquisition of drug resistance in several drug resistant cells (designated '/R') upon corresponding anticancer drug treatment. Supplementary Table 2. Docking and scoring known Hsp90 inhibitors into the C-terminal ATP binding pocket of Hsp90. Supplementary Figure 1. Chemical structure of SH-1242. Supplementary Figure 2. Inhibitory effect of SH-1242 on the viability of a panel of human lung cancer cells with or without anticancer drug resistance. Supplementary Figure 3. Minimal involvement of ROS in the regulation of Akt phosphorylation and apoptosis induction mediated by SH-1242 treatment.
Supplemental figures from The E3-ligase E6AP Represses Breast Cancer Metastasis via Regulation of ECT2-Rho Signaling
Authors: Mansour Mariam , Haupt Sue , Chan Ai-Leen , Godde Nathan , Rizzitelli Alexandra , Loi Sherene , Caramia Franco , Deb Siddhartha , Takano Elena A. , Bishton Mark , Johnstone Cameron , Monahan Brendon , Levav-Cohen Yarra , Jiang Yong-Hui , Yap Alpha S. , Fox Stephen , Bernard Ora , Anderson Robin , Haupt Ygal
Published: March 2023

supplemental figures
Supplemental Table 1 from Dietary Microbes Modulate Transgenerational Cancer Risk
Authors: Poutahidis Theofilos , Varian Bernard J. , Levkovich Tatiana , Lakritz Jessica R. , Mirabal Sheyla , Kwok Caitlin , Ibrahim Yassin M. , Kearney Sean M. , Chatzigiagkos Antonis , Alm Eric J. , Erdman Susan E.
Published: March 2023

Nutritional profile of special diets fed to mice.
Supplementary Figure S2 from Decreased Expression of Fructose-1,6-bisphosphatase Associates with Glucose Metabolism and Tumor Progression in Hepatocellular Carcinoma
Authors: Hirata Hidenari , Sugimachi Keishi , Komatsu Hisateru , Ueda Masami , Masuda Takaaki , Uchi Ryutaro , Sakimura Shotaro , Nambara Sho , Saito Tomoko , Shinden Yoshiaki , Iguchi Tomohiro , Eguchi Hidetoshi , Ito Shuhei , Terashima Kotaro , Sakamoto Katsumi , Hirakawa Masakazu , Honda Hiroshi , Mimori Koshi
Published: March 2023

FBP1 expression and mutational profiles across 234 HCC cases from The Cancer Genome Atlas.
Tables S1-S3 from Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types
Authors: Chartier Cecile , Raval Janak , Axelrod Fumiko , Bond Chris , Cain Jennifer , Dee-Hoskins Cristina , Ma Shirley , Fischer Marcus M. , Shah Jalpa , Wei Jie , Ji May , Lam Andrew , Stroud Michelle , Yen Wan-Ching , Yeung Pete , Cancilla Belinda , O'Young Gilbert , Wang Min , Kapoun Ann M. , Lewicki John , Hoey Timothy , Gurney Austin
Published: March 2023

Supplemental Tables include a list and brief description of xenograft models used in the study, the RSPO1-4 gene expression profile and beta-catenin activation status of all xenograft models, and the microarray analysis for 4 CRC xenograft models after treatment with anti-RSPO3 antibody.
Supplementary Figures 1-5 from Establishment and Characterization of an In Vitro Model of Ovarian Cancer Stem-like Cells with an Enhanced Proliferative Capacity
Authors: Ishiguro Tatsuya , Sato Ai , Ohata Hirokazu , Ikarashi Yoshinori , Takahashi Ryou-u , Ochiya Takahiro , Yoshida Masayuki , Tsuda Hitoshi , Onda Takashi , Kato Tomoyasu , Kasamatsu Takahiro , Enomoto Takayuki , Tanaka Kenichi , Nakagama Hitoshi , Okamoto Koji
Published: March 2023

Supplementary Fig. S1. Spheroid cells derived from human ovarian cancer show characteristics of CSCs. Supplementary Fig. S2. High levels of ALDH activity are associated with CSC-related characteristics. Supplementary Fig. S3. ALDH activity is required for SOX2 expression and proliferation of ovarian CSCs. Supplementary Fig. S4. ALDH1A1 mediates SOX2 expression and proliferation of ovarian CSCs. Supplementary Fig. S5. Feedback regulation by ALDH1A1 and SOX2 for the proliferation of ovarian CSCs.
Suppl. Figure 2 from Non–Small Cell Lung Cancer Cells Acquire Resistance to the ALK Inhibitor Alectinib by Activating Alternative Receptor Tyrosine Kinases
Authors: Isozaki Hideko , Ichihara Eiki , Takigawa Nagio , Ohashi Kadoaki , Ochi Nobuaki , Yasugi Masayuki , Ninomiya Takashi , Yamane Hiromichi , Hotta Katsuyuki , Sakai Katsuya , Matsumoto Kunio , Hosokawa Shinobu , Bessho Akihiro , Sendo Toshiaki , Tanimoto Mitsune , Kiura Katsuyuki
Published: March 2023

Identification by STR analysis
Supplementary Table S1 from Hypoxia-Induced Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma Induces an Immunosuppressive Tumor Microenvironment to Promote Metastasis
Authors: Ye Long-Yun , Chen Wei , Bai Xue-Li , Xu Xing-Yuan , Zhang Qi , Xia Xue-Feng , Sun Xu , Li Guo-Gang , Hu Qi-Da , Fu Qi-Han , Liang Ting-Bo
Published: March 2023

Correlation between the expression level of CCL20 (low or high) and clinicopathologic characteristics in HCC patients.
Supplementary Figure S1 from Hypoxia-Induced Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma Induces an Immunosuppressive Tumor Microenvironment to Promote Metastasis
Authors: Ye Long-Yun , Chen Wei , Bai Xue-Li , Xu Xing-Yuan , Zhang Qi , Xia Xue-Feng , Sun Xu , Li Guo-Gang , Hu Qi-Da , Fu Qi-Han , Liang Ting-Bo
Published: March 2023

HIF-1α knockdown prevents hypoxia-induced EMT.
Table S5 from RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non–Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway
Authors: Dubois Fatéméh , Keller Maureen , Calvayrac Olivier , Soncin Fabrice , Hoa Lily , Hergovich Alexander , Parrini Maria-Carla , Mazières Julien , Vaisse-Lesteven Mélissa , Camonis Jacques , Levallet Guénaëlle , Zalcman Gérard
Published: March 2023

Gene transcription variations after RASSF1A depletion in HBEC3 Cells using RT2 ProfilerTM Cell motility PCR Array (Qiagen). RNA isolated from HBEC-3 cells transfected with Si RASSF1A or Si Neg was reverse transcribed and relative gene expression data was obtained using the Human Cell motility PCR Arrays. The expression profile of 84 genes relevant to cell motility as well as 5 housekeeping genes was assayed. Fold change calculations were done using SABiosciences' data analysis software which automatically calculates the fold change in gene expression between the treated and control groups.
Figure S7: Time-course YAP cytoplasmic-nuclear shuttling upon RASSF1A depletion. from RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non–Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway
Authors: Dubois Fatéméh , Keller Maureen , Calvayrac Olivier , Soncin Fabrice , Hoa Lily , Hergovich Alexander , Parrini Maria-Carla , Mazières Julien , Vaisse-Lesteven Mélissa , Camonis Jacques , Levallet Guénaëlle , Zalcman Gérard
Published: March 2023

Representative images are shown for YAP localization changes, by immunofluorescence and confocal microscopy. HBEC-3 cells were transfected by inactive siNeg (upper lane), siRASS1A, siYAP or siRASSF1A plus siYAP (lower lane) and monitored 12, 24, 36 and 48h after transfection for YAP. The cells were stained by Yap primary antibody (Green) followed by Alexa488 conjugated secondary antibody, along with DAPI for DNA (Blue).
Figure S6. sh-mediated RASSF1A depletion in HBEC-3 cells. from RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non–Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway
Authors: Dubois Fatéméh , Keller Maureen , Calvayrac Olivier , Soncin Fabrice , Hoa Lily , Hergovich Alexander , Parrini Maria-Carla , Mazières Julien , Vaisse-Lesteven Mélissa , Camonis Jacques , Levallet Guénaëlle , Zalcman Gérard
Published: March 2023

HBEC-3 cells were transfected with non-silencing shRNA (Control), shRASSF1A-777 and shRASSF1A-779. A) Changes in RASSF1A and Yap expression assessed by immunofluorescence (Red=RASSF1A, Green=Yap, Blue=DAPI) experiments. Scale bar represents 50 µm. B) The migration speed (µm/h) of transfected cells was determined by wound assay on collagen IV. Mitomycin C (1 µg/ml) was added to medium 12h before wounding. The invasion capacity was assessed using a BioCoat Matrigel Invasion Chamber. The relative invasion was normalized to that of the cells transfected with Control. C) Representative images of colony formation of transfected cells in soft agar. Scale bar represents 20 µm. For all of the histograms, error bars indicate the standard error of the mean (SEM) of at least three independent experiments. *p<0.05, **p<0.01 and ***p<0.001, using an ANOVA test followed by Dunnett's test.
Supplemental Figure S5 from Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem–like Cells
Authors: Giraud Julie , Failla Laura M. , Pascussi Jean-Marc , Lagerqvist Ebba L. , Ollier Jérémy , Finetti Pascal , Bertucci François , Ya Chu , Gasmi Imène , Bourgaux Jean-François , Prudhomme Michel , Mazard Thibault , Ait-Arsa Imade , Houhou Leila , Birnbaum Daniel , Pélegrin André , Vincent Charles , Ryall James G. , Joubert Dominique , Pannequin Julie , Hollande Frédéric
Published: March 2023

Promotion of a glycolytic profile by progastrin is essential for the self-renewal ability of ALDHhigh cells.
Supplementary Figure 6 from Characterization of a c-Rel Inhibitor That Mediates Anticancer Properties in Hematologic Malignancies by Blocking NF-κB–Controlled Oxidative Stress Responses
Authors: Shono Yusuke , Tuckett Andrea Z. , Liou Hsiou-Chi , Doubrovina Ekaterina , Derenzini Enrico , Ouk Samedy , Tsai Jennifer J. , Smith Odette M. , Levy Emily R. , Kreines Fabiana M. , Ziegler Carly G.K. , Scallion Mary I. , Doubrovin Mikhail , Heller Glenn , Younes Anas , O'Reilly Richard J. , van den Brink Marcel R.M. , Zakrzewski Johannes L.
Published: March 2023

c-Rel inhibitor treatment is associated with partial recovery of lost body weight during severe acute GVHD.
Supplementary Figure 11 from Characterization of a c-Rel Inhibitor That Mediates Anticancer Properties in Hematologic Malignancies by Blocking NF-κB–Controlled Oxidative Stress Responses
Authors: Shono Yusuke , Tuckett Andrea Z. , Liou Hsiou-Chi , Doubrovina Ekaterina , Derenzini Enrico , Ouk Samedy , Tsai Jennifer J. , Smith Odette M. , Levy Emily R. , Kreines Fabiana M. , Ziegler Carly G.K. , Scallion Mary I. , Doubrovin Mikhail , Heller Glenn , Younes Anas , O'Reilly Richard J. , van den Brink Marcel R.M. , Zakrzewski Johannes L.
Published: March 2023

IT-901 inhibits growth of human DLBCL cell lines.
Supplemental Figure 1 from M-COPA, a Golgi Disruptor, Inhibits Cell Surface Expression of MET Protein and Exhibits Antitumor Activity against MET-Addicted Gastric Cancers
Authors: Ohashi Yoshimi , Okamura Mutsumi , Hirosawa Asaka , Tamaki Naomi , Akatsuka Akinobu , Wu Kuo-Ming , Choi Hyeong-Wook , Yoshimatsu Kentaro , Shiina Isamu , Yamori Takao , Dan Shingo
Published: March 2023

Dose-dependent effects on cell surface expression and processing of MET protein, and phosphorylation status of downstream signaling molecules.
Supplementary Figure 1 from Characterization of a c-Rel Inhibitor That Mediates Anticancer Properties in Hematologic Malignancies by Blocking NF-κB–Controlled Oxidative Stress Responses
Authors: Shono Yusuke , Tuckett Andrea Z. , Liou Hsiou-Chi , Doubrovina Ekaterina , Derenzini Enrico , Ouk Samedy , Tsai Jennifer J. , Smith Odette M. , Levy Emily R. , Kreines Fabiana M. , Ziegler Carly G.K. , Scallion Mary I. , Doubrovin Mikhail , Heller Glenn , Younes Anas , O'Reilly Richard J. , van den Brink Marcel R.M. , Zakrzewski Johannes L.
Published: March 2023

Analysis of the biochemical efficacy of IT-901 by electrophoretic mobility shift assay (EMSA) and NF-κB DNA binding ELISA.
Supplementary Table S3 from Quantitative Phosphotyrosine Profiling of Patient-Derived Xenografts Identifies Therapeutic Targets in Pediatric Leukemia
Authors: Dolai Sibasish , Sia Keith C.S. , Robbins Alissa K. , Zhong Ling , Heatley Sue L. , Vincent Tiffaney L. , Hochgräfe Falko , Sutton Rosemary , Kurmasheva Raushan T. , Revesz Tamas , White Deborah L. , Houghton Peter J. , Smith Malcolm A. , Teachey David T. , Daly Roger J. , Raftery Mark J. , Lock Richard B.
Published: March 2023

Intensities of all Class I phosphosites p(STY) light (PDX) and heavy (SILAC) identified in 16 PDXs
Supplementary Tables from MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin
Authors: O'Brien Rosemary , Tran Sieu L. , Maritz Michelle F. , Liu Bing , Kong Cheng Fei , Purgato Stefania , Yang Chen , Murray Jayne , Russell Amanda J. , Flemming Claudia L. , von Jonquieres Georg , Pickett Hilda A. , London Wendy B. , Haber Michelle , Gunaratne Preethi H. , Norris Murray D. , Perini Giovanni , Fletcher Jamie I. , MacKenzie Karen L.
Published: March 2023

Supplementary Table 1: siRNA sequences Supplementary Table 2: qRT-PCR primers Supplementary Table 3: Primers for chromatin immunoprecipitation Supplementary Table 4: Multivariate analysis of event free survival and overall survival of neuroblastoma patients
Supplementary Methods from MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin
Authors: O'Brien Rosemary , Tran Sieu L. , Maritz Michelle F. , Liu Bing , Kong Cheng Fei , Purgato Stefania , Yang Chen , Murray Jayne , Russell Amanda J. , Flemming Claudia L. , von Jonquieres Georg , Pickett Hilda A. , London Wendy B. , Haber Michelle , Gunaratne Preethi H. , Norris Murray D. , Perini Giovanni , Fletcher Jamie I. , MacKenzie Karen L.
Published: March 2023

Text file containing detailed methods.
Supplementary Figures from MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin
Authors: O'Brien Rosemary , Tran Sieu L. , Maritz Michelle F. , Liu Bing , Kong Cheng Fei , Purgato Stefania , Yang Chen , Murray Jayne , Russell Amanda J. , Flemming Claudia L. , von Jonquieres Georg , Pickett Hilda A. , London Wendy B. , Haber Michelle , Gunaratne Preethi H. , Norris Murray D. , Perini Giovanni , Fletcher Jamie I. , MacKenzie Karen L.
Published: March 2023

Supporting data; Supplementary Figure 1:Correlation analysis of DKC1 mRNA and dyskerin protein quantity in neuroblastoma cell lines Supplementary Figure 2:Correlation analysis of telomerase activity gene expression in neuroblastoma cells Supplementary Figure 3:Correlation analysis of TERT and MYC gene expression in neuroblastoma tumor samples Supplementary Figure 4:High DKC1 expression is a marker of poor prognosis in neuroblastoma Supplementary Figure 5:Analysis of TERT expression in neuroblastoma tumor samples Supplementary Figure 7: Upregulation of p21cip1 in NB69, but not SK-N-BE(2) cells following down regulation of dyskerin Supplementary Figure 8: Cell cycle and viability following downregulation of dyskerin
Supplementary Figure S3-6 from Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer
Authors: Dou Qianhui , Chen Hai-Ning , Wang Kui , Yuan Kefei , Lei Yunlong , Li Kai , Lan Jiang , Chen Yan , Huang Zhao , Xie Na , Zhang Lu , Xiang Rong , Nice Edouard C. , Wei Yuquan , Huang Canhua
Published: March 2023

Supplementary Figure S3-6
Supplemental Table S2 from Identification of Bone-Derived Factors Conferring De Novo Therapeutic Resistance in Metastatic Prostate Cancer
Authors: Lee Yu-Chen , Lin Song-Chang , Yu Guoyu , Cheng Chien-Jui , Liu Bin , Liu Hsuan-Chen , Hawke David H. , Parikh Nila U. , Varkaris Andreas , Corn Paul , Logothetis Christopher , Satcher Robert L. , Yu-Lee Li-Yuan , Gallick Gary E. , Lin Sue-Hwa
Published: March 2023

Mass spectrometry of Bone-CM from PCa-118b tumor-associated bone.
Supplementary figure S5 from JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification
Authors: Sun Wenyi , Xie Zuoquan , Liu Yifu , Zhao Dan , Wu Zhixiang , Zhang Dadong , Lv Hao , Tang Shuai , Jin Nan , Jiang Hualiang , Tan Minjia , Ding Jian , Luo Cheng , Li Jian , Huang Min , Geng Meiyu
Published: March 2023

The variable growth dependency of different cell lines on PDK1.
Supplementary Figure 2 from miR-155 Drives Metabolic Reprogramming of ER+ Breast Cancer Cells Following Long-Term Estrogen Deprivation and Predicts Clinical Response to Aromatase Inhibitors
Authors: Bacci Marina , Giannoni Elisa , Fearns Antony , Ribas Ricardo , Gao Qiong , Taddei Maria Letizia , Pintus Gianfranco , Dowsett Mitch , Isacke Clare M. , Martin Lesley-Ann , Chiarugi Paola , Morandi Andrea
Published: March 2023

Supplementary Figure S2. Hyperglycemia and normoglycemia do not affect glucose uptake and CO2 production in wt-MCF7 and MCF7-LTED.
Supplementary table 3 from Genomic Landscape of Somatic Alterations in Esophageal Squamous Cell Carcinoma and Gastric Cancer
Authors: Hu Nan , Kadota Mitsutaka , Liu Huaitian , Abnet Christian C. , Su Hua , Wu Hailong , Freedman Neal D. , Yang Howard H. , Wang Chaoyu , Yan Chunhua , Wang Lemin , Gere Sheryl , Hutchinson Amy , Song Guohong , Wang Yuan , Ding Ti , Qiao You-Lin , Koshiol Jill , Dawsey Sanford M. , Giffen Carol , Goldstein Alisa M. , Taylor Philip R. , Lee Maxwell P.
Published: March 2023

Summary of agreement between SNP5 and CGI data
Supplementary Figure S3 from Pharmacological Targeting of the Histone Chaperone Complex FACT Preferentially Eliminates Glioblastoma Stem Cells and Prolongs Survival in Preclinical Models
Authors: Dermawan Josephine Kam Tai , Hitomi Masahiro , Silver Daniel J. , Wu Qiulian , Sandlesh Poorva , Sloan Andrew E. , Purmal Andrei A. , Gurova Katerina V. , Rich Jeremy N. , Lathia Justin D. , Stark George R. , Venere Monica
Published: March 2023

No loss of viability was observed with an acute 24 h exposure to drug.
Supplemental Figure Legends from Pharmacological Targeting of the Histone Chaperone Complex FACT Preferentially Eliminates Glioblastoma Stem Cells and Prolongs Survival in Preclinical Models
Authors: Dermawan Josephine Kam Tai , Hitomi Masahiro , Silver Daniel J. , Wu Qiulian , Sandlesh Poorva , Sloan Andrew E. , Purmal Andrei A. , Gurova Katerina V. , Rich Jeremy N. , Lathia Justin D. , Stark George R. , Venere Monica
Published: March 2023

This file contains figure legends to supplemental figures S1-S5.
Supplementary Table 2 from Design and Reporting of Targeted Anticancer Preclinical Studies: A Meta-Analysis of Animal Studies Investigating Sorafenib Antitumor Efficacy
Authors: Mattina James , MacKinnon Nathalie , Henderson Valerie C. , Fergusson Dean , Kimmelman Jonathan
Published: March 2023

Coding details for construct validity categories in Table 2. Adapted from our previous meta-analysis of the drug, sunitinib (5).
Figure S5 from Synergistic Activation of ERα by Estrogen and Prolactin in Breast Cancer Cells Requires Tyrosyl Phosphorylation of PAK1
Authors: Oladimeji Peter , Skerl Rebekah , Rusch Courtney , Diakonova Maria
Published: March 2023

This file contains Supplemental Figure S5 entitled "Synergistic effect of PRL and E2 on cell proliferation".
Figure S1 from Synergistic Activation of ERα by Estrogen and Prolactin in Breast Cancer Cells Requires Tyrosyl Phosphorylation of PAK1
Authors: Oladimeji Peter , Skerl Rebekah , Rusch Courtney , Diakonova Maria
Published: March 2023

This file contains Supplemental Figure S1 entitled "Estrogen regulates proliferation of breast cancer cells through PAK1 activation".
Supplementary Figure Legends from BPTF Depletion Enhances T-cell–Mediated Antitumor Immunity
Authors: Mayes Kimberly , Alkhatib Suehyb G. , Peterson Kristen , Alhazmi Aiman , Song Carolyn , Chan Vivian , Blevins Tana , Roberts Mark , Dumur Catherine I. , Wang Xiang-Yang , Landry Joseph W.
Published: March 2023

Supplemental figure legends for Mayes et al.
Figure S7&S8 from Restraining Network Response to Targeted Cancer Therapies Improves Efficacy and Reduces Cellular Resistance
Authors: Das Tirtha K. , Esernio Jessica , Cagan Ross L.
Published: March 2023

Figure S7, S8, shows effect of sorafenib/bortezomib/vorinostat on TT cell tumor xenografts in mice and effect of 'network brake' drug combinations on different human cancer cells
Supplementary figure 6 from Abscopal Effects of Radiotherapy Are Enhanced by Combined Immunostimulatory mAbs and Are Dependent on CD8 T Cells and Crosspriming
Authors: Rodriguez-Ruiz María E. , Rodriguez Inmaculada , Garasa Saray , Barbes Benigno , Solorzano Jose Luis , Perez-Gracia Jose Luis , Labiano Sara , Sanmamed Miguel F. , Azpilikueta Arantza , Bolaños Elixabet , Sanchez-Paulete Alfonso R. , Aznar M. Angela , Rouzaut Ana , Schalper Kurt A. , Jure-Kunkel Maria , Melero Ignacio
Published: March 2023

Ex-vivo irradiation of human carcinoma surgical expecimens gives rise to more intense expression of CD137 and PD-1 on infiltrating lymphocytes.
Supplementary Figures S1-S7 from Histone Deacetylase Inhibition in Prostate Cancer Triggers miR-320–Mediated Suppression of the Androgen Receptor
Authors: Sato Shinya , Katsushima Keisuke , Shinjo Keiko , Hatanaka Akira , Ohka Fumiharu , Suzuki Shugo , Naiki-Ito Aya , Soga Norihito , Takahashi Satoru , Kondo Yutaka
Published: March 2023

Supplementary Fig. S1. Effect of OBP-801 and other HDAC inhibitors in prostate cancer cells. Supplementary Fig. S2. Western blot analysis of prostate cancer cells treated with OBP-801 or other HDAC inhibitors. Supplementary Fig. S3. Expression analysis of miR-320a, miR-320c, and miR-3065 in prostate cancer cells treated with OBP-801. Supplementary Fig. S4. Luciferase assay of AR 3'UTR with deletion or mutation in miR-320atarget sites. Supplementary Fig. S5. Inhibition of tumor growth and AR expression by OBP-801 in the 22Rv1 xenograft model. Supplementary Fig. S6. Predicted binding sites of rat miR-320aare indicated (arrowheads) in the rat Ar3'-UTR. Supplementary Fig. S7. Effects of combination therapies of OBP-801 and other conventional anti-androgen or chemotherapeutic agents in prostate cancer cell lines.
Supplementary Figures S1-7 and Tables S1-2 from Urokinase Receptor Promotes Skin Tumor Formation by Preventing Epithelial Cell Activation of Notch1
Authors: Mazzieri Roberta , Pietrogrande Giovanni , Gerasi Laura , Gandelli Alessandro , Colombo Piergiuseppe , Moi Davide , Brombin Chiara , Ambrosi Alessandro , Danese Silvio , Mignatti Paolo , Blasi Francesco , D'Alessio Silvia
Published: March 2023

This file include Supplementary Figures S1-7 and Tables S1-2. Figure S1. Inflammation and neo-angiogenesis are not impaired in TPA-treated uPAR-/- skin. Figure S2. Distinct stages of hair cycling in uPAR+/+ and uPAR-/- littermates. Figure S3. FACS isolation of K14-GFP-actin/uPAR+/+ and K14-GFP-actin/uPAR-/- mouse epidermal cell sub-populations. Figure S4. Long-term growth of FACS-sorted epidermal cell subpopulations. Figure S5. Determination of "differentiated" and "proliferating" human Keratoacanthomas. Figure S6. uPAR promotes skin epithelial cell response to a proliferative stimulus by TACE-dependent Notch1 activation. Figure S7. uPAR sequesters the shedding activity of TACE in lipid rafts, thus inhibiting differentiation of primary keratinocytes. Table S1. Estimates, corresponding standard errors and P values of the fitted zero-inflated regression models. Table S2. Number of uPAR+/+ and uPAR-/- hair follicles/section in the telogen, anagen, and catagen stages.
Supplemental Figure Legend from Discordant Haplotype Sequencing Identifies Functional Variants at the 2q33 Breast Cancer Risk Locus
Authors: Camp Nicola J. , Lin Wei-Yu , Bigelow Alex , Burghel George J. , Mosbruger Timothy L. , Parry Marina A. , Waller Rosalie G. , Rigas Sushilaben H. , Tai Pei-Yi , Berrett Kristofer , Rajamanickam Venkatesh , Cosby Rachel , Brock Ian W. , Jones Brandt , Connley Dan , Sargent Robert , Wang Guoying , Factor Rachel E. , Bernard Philip S. , Cannon-Albright Lisa , Knight Stacey , Abo Ryan , Werner Theresa L. , Reed Malcolm W.R. , Gertz Jason , Cox Angela
Published: March 2023

Supplemental Figure Legend
Supplementary Methods from Androgen Receptor Upregulation Mediates Radioresistance after Ionizing Radiation
Authors: Spratt Daniel E. , Evans Michael J. , Davis Brian J. , Doran Michael G. , Lee Man Xia , Shah Neel , Wongvipat John , Carnazza Kathryn E. , Klee George G. , Polkinghorn William , Tindall Donald J. , Lewis Jason S. , Sawyers Charles L.
Published: March 2023

Supplementary Methods Additional methodology of experimental methods.
Supplementary Figure Legends from Androgen Receptor Upregulation Mediates Radioresistance after Ionizing Radiation
Authors: Spratt Daniel E. , Evans Michael J. , Davis Brian J. , Doran Michael G. , Lee Man Xia , Shah Neel , Wongvipat John , Carnazza Kathryn E. , Klee George G. , Polkinghorn William , Tindall Donald J. , Lewis Jason S. , Sawyers Charles L.
Published: March 2023

Supplementary Figure legends for Supplementary Figure 1 and 2
Supplementary Figure Legend from Endothelial Side Population Cells Contribute to Tumor Angiogenesis and Antiangiogenic Drug Resistance
Authors: Naito Hisamichi , Wakabayashi Taku , Kidoya Hiroyasu , Muramatsu Fumitaka , Takara Kazuhiro , Eino Daisuke , Yamane Keitaro , Iba Tomohiro , Takakura Nobuyuki
Published: March 2023

Supplementary figure legend for supplementary figure S1
Supplementary Figure 2 from Germinal Centers Determine the Prognostic Relevance of Tertiary Lymphoid Structures and Are Impaired by Corticosteroids in Lung Squamous Cell Carcinoma
Authors: Siliņa Karīna , Soltermann Alex , Attar Farkhondeh Movahedian , Casanova Ruben , Uckeley Zina M. , Thut Helen , Wandres Muriel , Isajevs Sergejs , Cheng Phil , Curioni-Fontecedro Alessandra , Foukas Periklis , Levesque Mitchell P. , Moch Holger , Linē Aija , van den Broek Maries
Published: March 2023

Immunofluorescence images depicting three TLS maturation stages throughout the entire depth of each TLS.
Supplementary Materials and Methods from Eritoran Suppresses Colon Cancer by Altering a Functional Balance in Toll-like Receptors That Bind Lipopolysaccharide
Authors: Kuo Wei-Ting , Lee Tsung-Chun , Yu Linda Chia-Hui
Published: March 2023

Detailed information of materials and methods
Supplementary Figure 2 from Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability
Authors: Li Xiangchun , Wu William K.K. , Xing Rui , Wong Sunny H. , Liu Yuexin , Fang Xiaodong , Zhang Yanlin , Wang Mengyao , Wang Jiaqian , Li Lin , Zhou Yong , Tang Senwei , Peng Shaoliang , Qiu Kunlong , Chen Longyun , Chen Kexin , Yang Huanming , Zhang Wei , Chan Matthew T.V. , Lu Youyong , Sung Joseph J.Y. , Yu Jun
Published: March 2023

Fig. S2: Prognostic significance of C1/2.
Supplementary Figure 1 from Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability
Authors: Li Xiangchun , Wu William K.K. , Xing Rui , Wong Sunny H. , Liu Yuexin , Fang Xiaodong , Zhang Yanlin , Wang Mengyao , Wang Jiaqian , Li Lin , Zhou Yong , Tang Senwei , Peng Shaoliang , Qiu Kunlong , Chen Longyun , Chen Kexin , Yang Huanming , Zhang Wei , Chan Matthew T.V. , Lu Youyong , Sung Joseph J.Y. , Yu Jun
Published: March 2023

Fig. S1: Optimization of number of molecular subtypes and assessment of batch effects.
Supplementary Dataset 1 from Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability
Authors: Li Xiangchun , Wu William K.K. , Xing Rui , Wong Sunny H. , Liu Yuexin , Fang Xiaodong , Zhang Yanlin , Wang Mengyao , Wang Jiaqian , Li Lin , Zhou Yong , Tang Senwei , Peng Shaoliang , Qiu Kunlong , Chen Longyun , Chen Kexin , Yang Huanming , Zhang Wei , Chan Matthew T.V. , Lu Youyong , Sung Joseph J.Y. , Yu Jun
Published: March 2023

Clinical data of gastric cancer patients whose genomic data was aggregrated for integrated analysis.
Supplementary Figure 1 from Eritoran Suppresses Colon Cancer by Altering a Functional Balance in Toll-like Receptors That Bind Lipopolysaccharide
Authors: Kuo Wei-Ting , Lee Tsung-Chun , Yu Linda Chia-Hui
Published: March 2023

Intravenous administration of eritoran decreases colon tumor growth in a dose-dependent manner.
Supplementary Table S1 from TG2 and NF-κB Signaling Coordinates the Survival of Mantle Cell Lymphoma Cells via IL6-Mediated Autophagy
Authors: Zhang Han , Chen Zheng , Miranda Roberto N. , Medeiros L. Jeffrey , McCarty Nami
Published: March 2023

Effects of paracrine IL-6 on colony formation in MCL cells.
Supplementary Table S2 from Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma
Authors: Vatolin Sergei , Phillips James G. , Jha Babal K. , Govindgari Shravya , Hu Jennifer , Grabowski Dale , Parker Yvonne , Lindner Daniel J. , Zhong Fei , Distelhorst Clark W. , Smith Mitchell R. , Cotta Claudiu , Xu Yan , Chilakala Sujatha , Kuang Rebecca R. , Tall Samantha , Reu Frederic J.
Published: March 2023

Mass spectrometric analysis of proteins that bound to B-CCF642 in MM1.S cells
Supplementary Methods and References from TG2 and NF-κB Signaling Coordinates the Survival of Mantle Cell Lymphoma Cells via IL6-Mediated Autophagy
Authors: Zhang Han , Chen Zheng , Miranda Roberto N. , Medeiros L. Jeffrey , McCarty Nami
Published: March 2023

Description of additional methods and procedures used in the study. Also includes Supplementary References.
Supplementary Table S1 from Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma
Authors: Vatolin Sergei , Phillips James G. , Jha Babal K. , Govindgari Shravya , Hu Jennifer , Grabowski Dale , Parker Yvonne , Lindner Daniel J. , Zhong Fei , Distelhorst Clark W. , Smith Mitchell R. , Cotta Claudiu , Xu Yan , Chilakala Sujatha , Kuang Rebecca R. , Tall Samantha , Reu Frederic J.
Published: March 2023

Small molecule screening data
Supplementary Figure Legends from GON4L Drives Cancer Growth through a YY1–Androgen Receptor–CD24 Axis
Authors: Agarwal Neeraj , Dancik Garrett M. , Goodspeed Andrew , Costello James C. , Owens Charles , Duex Jason E. , Theodorescu Dan
Published: March 2023

Legends for supplementary figures
Supplemental materials and methods from GON4L Drives Cancer Growth through a YY1–Androgen Receptor–CD24 Axis
Authors: Agarwal Neeraj , Dancik Garrett M. , Goodspeed Andrew , Costello James C. , Owens Charles , Duex Jason E. , Theodorescu Dan
Published: March 2023

Supplementary materials and methods
Supplementary Figure legends from Drosophila Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport
Authors: Mukherjee Subhas , Tucker-Burden Carol , Zhang Changming , Moberg Kenneth , Read Renee , Hadjipanayis Costas , Brat Daniel J.
Published: March 2023

This file contains Supplementary figure legends.
Supplemental Figure 6 Drosophila brat-RNAi brains show increased Musashi expression. from Drosophila Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport
Authors: Mukherjee Subhas , Tucker-Burden Carol , Zhang Changming , Moberg Kenneth , Read Renee , Hadjipanayis Costas , Brat Daniel J.
Published: March 2023

Immunofluorescence for Drosophila Musashi in the Drosophila brat-RNAi brain shows that there is a moderate increase in Musashi expression when Brat protein is suppressed in neuroblasts (A-E).
Supplemental Figure 4 Effects of TRIM3 upregulating and downregulation in mammalian models. from Drosophila Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport
Authors: Mukherjee Subhas , Tucker-Burden Carol , Zhang Changming , Moberg Kenneth , Read Renee , Hadjipanayis Costas , Brat Daniel J.
Published: March 2023

(A) Western blot of N08-74 VC and N08-74-TRIM3 expressing cells and 13113 VC and 13113-TRIM3 expressing cells. TRIM3 expression does not increase the glial cell marker GFAP or neuronal marker TUJ-1. (B) TRIM3 sh-RNA in NHNP cells reduces the TRIM3 expression. TRIM3 suppression does not increase total or cytosolic NICD but increases NICD nuclear localization (B,C,D). Nuclear and cytosolic extracts show presence of TRIM3 in the cytosol, but not in nucleus (E).
Supplementary figure 1 from A Preclinical Model of Chronic Alcohol Consumption Reveals Increased Metastatic Seeding of Colon Cancer Cells in the Liver
Authors: Im Hwi-Jin , Kim Hyeong-Geug , Lee Jin-Seok , Kim Hyo-Seon , Cho Jung-Hyo , Jo Il-Joo , Park Sung-Joo , Son Chang-Gue
Published: March 2023

Experimental models
Supplementary Methods and References from Antitumor Properties of an IgG2-Enhanced Next-Generation MET Monoclonal Antibody That Degrades Wild-Type and Mutant MET Receptors
Authors: Yang Yan , Mandiyan Sreekala , Robinson Brett S. , McMahon Gerald
Published: March 2023

Description of additional methods and procedures used in the study. Also includes Supplementary References.
Supplementary Figures S1-S4 from Antitumor Properties of an IgG2-Enhanced Next-Generation MET Monoclonal Antibody That Degrades Wild-Type and Mutant MET Receptors
Authors: Yang Yan , Mandiyan Sreekala , Robinson Brett S. , McMahon Gerald
Published: March 2023

Anti-MET antibodies demonstrated no agonistic activities in proliferation assay (S1); Sequence alignment of Sema domain β-subunit of human, monkey, canine and murine MET receptors (S2); Effect of KTN0073-IgG1, IgG2 and IgG4 antibodies on HGF-dependent MET phosphorylation in U87MG cell (S3); Differential effect of IgG2 isotype switching on KTN0070, KTN0071 and KTN0075 (S4).
Supplementary Figure 3 from The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis
Authors: Astudillo Luisana , Da Silva Thiago G. , Wang Zhiqiang , Han Xiaoqing , Jin Ke , VanWye Jeffrey , Zhu Xiaoxia , Weaver Kelly , Oashi Taiji , Lopes Pedro E.M. , Orton Darren , Neitzel Leif R. , Lee Ethan , Landgraf Ralf , Robbins David J. , MacKerell Alexander D. , Capobianco Anthony J.
Published: March 2023

IMR-1 treatment does not induce weight loss in treated mice.
Supplementary Table 1 from Multiplex H. pylori Serology and Risk of Gastric Cardia and Noncardia Adenocarcinomas
Authors: Shakeri Ramin , Malekzadeh Reza , Nasrollahzadeh Dariush , Pawilta Michael , Murphy Gwen , Islami Farhad , Sotoudeh Masoud , Michel Angelika , Etemadi Arash , Waterboer Tim , Poustchi Hossein , Brennan Paul , Boffetta Paolo , Dawsey Sanford M. , Kamangar Farin , Abnet Christian C.
Published: March 2023

Association of different combinations of four antibodies (CagA, VacA, NapA, and GroEL) with gastric adenocarcinoma and its subtypes.
Figure S5 from Nkx2.8 Inhibits Epithelial–Mesenchymal Transition in Bladder Urothelial Carcinoma via Transcriptional Repression of Twist1
Authors: Yu Chunping , Liu Zhuowei , Chen Qiuhong , Li Yonghong , Jiang Lijuan , Zhang Zhiling , Zhou Fangjian
Published: March 2023

Ablation of Twist1 restores the inhibitory effect of Nkx2.8 on the motility of Nkx2.8-silenced UC cells
Figure S5 from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer
Authors: Hall Zoe , Ament Zsuzsanna , Wilson Catherine H. , Burkhart Deborah L. , Ashmore Tom , Koulman Albert , Littlewood Trevor , Evan Gerard I. , Griffin Julian L.
Published: March 2023

Example chromatograms for eicosanoid analysis by LC-MS/MS.
Figure S3 from Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer
Authors: Hall Zoe , Ament Zsuzsanna , Wilson Catherine H. , Burkhart Deborah L. , Ashmore Tom , Koulman Albert , Littlewood Trevor , Evan Gerard I. , Griffin Julian L.
Published: March 2023

Liquid extraction surface analysis mass spectrometry differentiates normal from tumour tissue.
Supplementary Materials and Methods, Supplementary Tables 1 through 3, and Supplementary Figure 1 from The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models
Authors: Oplustil O'Connor Lenka , Rulten Stuart L. , Cranston Aaron N. , Odedra Rajesh , Brown Henry , Jaspers Janneke E. , Jones Louise , Knights Charlotte , Evers Bastiaan , Ting Attilla , Bradbury Robert H. , Pajic Marina , Rottenberg Sven , Jonkers Jos , Rudge David , Martin Niall M.B. , Caldecott Keith W. , Lau Alan , O'Connor Mark J.
Published: March 2023

Supplementary materials and methods. Suppl Table 1. MMS combination PF50 cell line assays. Concentration-dependent potentiation of MMS (PF50 ratios). Suppl Table 2. Permeability of AZD2461 and olaparib were assessed. Suppl Table 3. Activity of olaparib and AZD2461 alone or in combination with the P-gp inhibitor verapamil in the colorectal cancer cell line HCT-15, which expresses high levels of P-gp. Suppl Fig. 1. Immunofluorescence for poly(ADP-ribose) in human A549 cells. Suppl Fig. 2. Analysis of both in vivo pharmacokinetics (PK) and pharmacodynamics (PD) in tumors taken from SW620 (human colon carcinoma) xenograft-bearing mice. Suppl Fig. 3. Colony formation (clonogenic) assays in the intrinsically high P-gp-expressing MRE11-deficient HCT-15 human colorectal cell line. Suppl. Fig. 4. Combination efficacy studies. Suppl Fig. 5. Relative body weight changes in mice following treatment with 10 mg/kg AZD2461 and olaparib in combination with temozolomide. Suppl. Fig. 6. A serial dilution of RNA concentration was used to establish a standard curve for determining the reaction efficiency of PARP1, PARP2, PARP3, and housekeeper gene (PPIA: cyclophilin A) TaqMan RT-PCR assays in both rat and mouse species; Determination of optimal reference gene for rat-mouse data normalization. Suppl Fig. 7.A. A serial dilution of reference RNA (Qiagen) concentration was used to establish a standard curve for determining the reaction efficiency of PARP3 and housekeeper genes (PPIA: cyclophilin and YWHAZ: tyrosine 3-monooxygenase/tryptohpan 5-monooxygenase activation protein, zeta polypeptide) SybrGreen RT-PCR assays in both rat and human species; Determination of optimal reference gene for rat-human data normalization. Suppl Fig. 8. Relative body weight changes in rat following treatment with 10 mg/kg AZD2461 and olaparib in combination with temozolomide; Relative body weight changes in rat following treatment with 20 mg/kg AZD2461 and olaparib in combination with temozolomide.
Figure S3 from RASSF1A Directly Antagonizes RhoA Activity through the Assembly of a Smurf1-Mediated Destruction Complex to Suppress Tumorigenesis
Authors: Lee Min-Goo , Jeong Seong-In , Ko Kyung-Phil , Park Soon-Ki , Ryu Byung-Kyu , Kim Ick-Young , Kim Jeong-Kook , Chi Sung-Gil
Published: March 2023

Figure S3. Smurf1-dependent RASSF1A stimulation of RhoA ubiquitination. A, RASSF1A promotes RhoA degradation in a Smurf1-dependent manner. HCT116 cells were transfected with siSmurf1 and/or RASSF1A-V5 and then treated with CHX (10 Î¼M) for the indicated times. B, Stimulation of RhoA ubiquitination by RASSF1A but not by RASSF1C. A549 cells were co-transfected with His-Ub and RASSF1A-V5 or RASSF1C-V5. After 48 h transfection, cell lysates were subjected to immunoprecipitation and subsequent immunoblot using anti-His and anti-RhoA, respectively. C. Inhibition of RASSF1A-induced RhoA ubiquitination by siSmurf1-3UTR transfection and rescue of RhoA ubiquitination by siRNA-nontargetable Smurf1 transfection. siSmurf1-3UTR (5'-GGTGTTCTAGAAGCCCGTT-3') was designed to target the 3'-UTR region of Smurf1 transcript. D, A critical role of Smurf1 for RASSF1A-induced RhoA ubiquitination. A549 cells were co-transfected with RASSF1A-V5 and either WT- or DN-Smurf1 and cell lysates were prepared at 48 h post-transfection. Based on RhoA immunoblot, equal amounts of RhoA (input) were subjected to immunoprecipitation and subsequent immunoblot was performed using anti-His. E, Identification of the HECT domain of Smurf1 as a critical region for the interaction with RASSF1A. A549 cells were co-transfected with Flag-tagged Smurf1 deletion mutants and RASSF1A-V5 and their interaction was determined by immunoprecipitation assays. F, Schematic representation of RASSF1A binding to Smurf1 and RhoA via the N-terminal 69-82 resides and the C-terminal 256-277 residues, respectively.
Supplemental Figures and Tables from Notch4 Signaling Induces a Mesenchymal–Epithelial–like Transition in Melanoma Cells to Suppress Malignant Behaviors
Authors: Bonyadi Rad Ehsan , Hammerlindl Heinz , Wels Christian , Popper Ulrich , Ravindran Menon Dinoop , Breiteneder Heimo , Kitzwoegerer Melitta , Hafner Christine , Herlyn Meenhard , Bergler Helmut , Schaider Helmut
Published: March 2023

SF1: Phenotypic and functional changes of 451Lu, WM9 and WM164 following N4ICD overexpression SF2: Immunoblots and immunohistochemistry of EMT markers and Notch4 SF3: Details of CSL binding to Snail2 and Twist1 promoter regions SF4: Immunoblots of overexpression and silencing experiments confirming the Notch4-Hey1/2-Snail2/Twist1 axis (SF4) SF5: Immunoblots of pLNCX-N4ICD and siHey1/2 transduced cells and details of Snail2 and Twist1 promoter regions ST1: Plasmids and siRNAs ST2: Antibodies ST3: Primers for qPCR and ChIP ST4: Sequence of EMSA fragments ST5: Sequence of luciferase fragments ST6: Fold regulation of EMT markers determined by PCR-array ST7: Details of immunohistochemical analyses of melanoma samples Supplementary references
Suplemental methods from PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma
Authors: Agnihotri Sameer , Golbourn Brian , Huang Xi , Remke Marc , Younger Susan , Cairns Rob A. , Chalil Alan , Smith Christian A. , Krumholtz Stacey-Lynn , Mackenzie Danielle , Rakopoulos Patricia , Ramaswamy Vijay , Taccone Michael S. , Mischel Paul S. , Fuller Gregory N. , Hawkins Cynthia , Stanford William L. , Taylor Michael D. , Zadeh Gelareh , Rutka James T.
Published: March 2023

Suplemental methods for experiments appearing in supplemental data and expanded details from methods in main manuscript.
Suplemental Figure Legends from PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma
Authors: Agnihotri Sameer , Golbourn Brian , Huang Xi , Remke Marc , Younger Susan , Cairns Rob A. , Chalil Alan , Smith Christian A. , Krumholtz Stacey-Lynn , Mackenzie Danielle , Rakopoulos Patricia , Ramaswamy Vijay , Taccone Michael S. , Mischel Paul S. , Fuller Gregory N. , Hawkins Cynthia , Stanford William L. , Taylor Michael D. , Zadeh Gelareh , Rutka James T.
Published: March 2023

Suplemental Figure Legends for supplemental data
Supplemental table 2 from An Imbalance in TAZ and YAP Expression in Hepatocellular Carcinoma Confers Cancer Stem Cell–like Behaviors Contributing to Disease Progression
Authors: Hayashi Hiromitsu , Higashi Takaaki , Yokoyama Naomi , Kaida Takayoshi , Sakamoto Keita , Fukushima Yukiko , Ishimoto Takatsugu , Kuroki Hideyuki , Nitta Hidetoshi , Hashimoto Daisuke , Chikamoto Akira , Oki Eiji , Beppu Toru , Baba Hideo
Published: March 2023

Association between TAZ or YAP mRNA expression and patient's characteristics in hepatocellular carcinoma
Supplemental Figure 7: Chao1 and Shannon richness estimates and indicator OTUs for AOM/DSS mice. from HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis
Authors: Lang Michaela , Berry David , Passecker Katharina , Mesteri Ildiko , Bhuju Sabin , Ebner Florian , Sedlyarov Vitaly , Evstatiev Rayko , Dammann Kyle , Loy Alexander , Kuzyk Orest , Kovarik Pavel , Khare Vineeta , Beibel Martin , Roma Guglielmo , Meisner-Kober Nicole , Gasche Christoph
Published: March 2023

Alpha diversity in feces of AOM/DSS and APCMin upon MS-444 treatment and indicator OTUs in AOM/DSS mouse feces.
Supplemental methods from An Imbalance in TAZ and YAP Expression in Hepatocellular Carcinoma Confers Cancer Stem Cell–like Behaviors Contributing to Disease Progression
Authors: Hayashi Hiromitsu , Higashi Takaaki , Yokoyama Naomi , Kaida Takayoshi , Sakamoto Keita , Fukushima Yukiko , Ishimoto Takatsugu , Kuroki Hideyuki , Nitta Hidetoshi , Hashimoto Daisuke , Chikamoto Akira , Oki Eiji , Beppu Toru , Baba Hideo
Published: March 2023

Supplemental methods