bluuebunny/crossref_metadata_2025 huggingface dataset:
Peripheral biomarkers of treatment-resistant schizophrenia: Genetic, inflammation and stress perspectives
Authors: Jiao Shimeng , Cao Ting , Cai Hualin
Published: October 2022

Treatment-resistant schizophrenia (TRS) often results in severe disability and functional impairment. Currently, the diagnosis of TRS is largely exclusionary and emphasizes the improvement of symptoms that may not be detected early and treated according to TRS guideline. As the gold standard, clozapine is the most prescribed selection for TRS. Therefore, how to predict TRS in advance is critical for forming subsequent treatment strategy especially clozapine is used during the early stage of TRS. Although mounting studies have identified certain clinical factors and neuroimaging characteristics associated with treatment response in schizophrenia, the predictors for TRS remain to be explored. Biomarkers, particularly for peripheral biomarkers, show great potential in predicting TRS in view of their predictive validity, noninvasiveness, ease of testing and low cost that would enable their widespread use. Recent evidence supports that the pathogenesis of TRS may be involved in abnormal neurotransmitter systems, inflammation and stress. Due to the heterogeneity of TRS and the lack of consensus in diagnostic criteria, it is difficult to compare extensive results among different studies. Based on the reported neurobiological mechanisms that may be associated with TRS, this paper narratively reviews the updates of peripheral biomarkers of TRS, from genetic and other related perspectives. Although current evidence regarding biomarkers in TRS remains fragmentary, when taken together, it can help to better understand the neurobiological interface of clinical phenotypes and psychiatric symptoms, which will enable individualized prediction and therapy for TRS in the long run.
A mechanistic review of chinese medicine polyphenols on bone formation and resorption
Authors: Li Yan , Li Lingyu , Li Xiaoyun , Luo Bingjie , Ye Qianyun , Wang Haoyu , Yang Li , Zhu Xiaofeng , Han Li , Zhang Ronghua , Tian Huaqin , Wang Panpan
Published: October 2022

Bone reconstruction includes a steady state system of bone formation and bone absorption. This tight coupling requires subtle coordination between osteoblasts and osteoclasts. If this balance is broken, it will lead to bone mass loss, bone density reduction, and bone metabolic diseases, such as osteoporosis. Polyphenols in Chinese herbal medicines are active ingredients in plant extracts with high safety and few side effects, and they can play a role in affecting bone formation and bone resorption. Some of these have estrogen-like effects and can better target bone health in postmenopausal women. The purpose of this review is to provide comprehensive information on the mechanisms underlying the relationship between traditional Chinese medicine polyphenols and bone formation or bone resorption.
m6A/ m1A /m5C/m7G-related methylation modification patterns and immune characterization in prostate cancer
Authors: Ye Xin , Wang Ruyi , Yu Xiaoqian , Wang Zili , Hu Haifeng , Zhang Hanchao
Published: October 2022

Methylation has a close relationship with immune reactions, metastasis, and cancer cell growth. Additionally, RNA methylation-related proteins have emerged as potential cancer therapeutic targets. The connection between the tumor microenvironment (TME) and methylation-related genes (MRGs) remains unclear. We explored the expression patterns of the MRGs in the genome and transcriptional fields of 796 prostate cancer (PCa) samples using two separate data sets. We identified a relationship between patient clinicopathological characteristics, prognosis, TME cell infiltrating qualities, and different MRG changes, as well as the identification of two distinct molecular groupings. Then, we formed an MRGs model to predict overall survival (OS), and we tested the accuracy of the model in patients with PCa. In addition, we developed a very accurate nomogram to improve the MRG model’s clinical applicability. The low-risk group had fewer tumor mutational burden (TMB), greater tumor immune dysfunction and exclusion (TIDE) ratings, fewer mutant genes, and better OS prospects. We discuss how MGRs may affect the prognosis, clinically important traits, TME, and immunotherapy responsiveness in PCa. In order to get a better understanding of MRGs in PCa, we could further explore the prognosis and create more effective immunotherapy regimens to open new avenues.
Establishment and large-scale validation of a three-dimensional tumor model on an array chip for anticancer drug evaluation
Authors: Xiao Rong-Rong , Jin Lei , Xie Nan , Luo Piaopiao , Gao Wenjie , Tu Pengfei , Ai Xiaoni
Published: October 2022

Two-dimensional (2D) tumor model has always poorly predicted drug response of animal model due to the lack of recapitulation of tumor microenvironment. Establishing a biomimetic, controllable, and cost-effective three-dimensional (3D) model and large-scale validation of its in vivo predictivity has shown promise in bridging the gap between the 2D tumor model and animal model. Here, we established a matrigel-based 3D micro-tumor model on an array chip for large-scale anticancer drug evaluation. Compared with the 2D tumor model, the 3D tumor model on the chip showed spheroid morphology, slower proliferation kinetics, and comparable reproducibility. Next, the results of the chemotherapeutic evaluation from 18 drugs against 27 cancer cell lines showed 17.6% of drug resistance on the 3D tumor model. Moreover, the evaluation results of targeted drugs showed expected sensitivity and higher specificity on the 3D tumor model compared with the 2D model. Finally, the evaluation results on the 3D tumor model were more consistent with the in vivo cell-derived xenograft model, and excluded 95% false-positive results from the 2D model. Overall, the matrigel-based 3D micro-tumor model on the array chip provides a promising tool to accelerate anticancer drug discovery.
Preclinical reserpine models recapitulating motor and non-motor features of Parkinson’s disease: Roles of epigenetic upregulation of alpha-synuclein and autophagy impairment
Authors: Li Yang , Yin Qiao , Wang Bing , Shen Tingting , Luo Weifeng , Liu Tong
Published: October 2022

Reserpine is an effective drug for the clinical treatment of hypertension. It also induces Parkinson’s disease (PD)-like symptoms in humans and animals possible through the inhibition of monoamine vesicular transporters, thus decreasing the levels of monoamine neurotransmitters in the brain. However, the precise mechanisms remain unclear. Herein, we aimed to develop a preclinical reserpine model recapitulating the non-motor and motor symptoms of PD and investigate the underlying potential cellular mechanisms. Incubation of reserpine induced apoptosis, led to the accumulation of intracellular reactive oxygen species (ROS), lowered DNA methylation of alpha-synuclein gene, resulted in alpha-synuclein protein deposition, and elevated the ratio of LC3-II/LC3-Ⅰ and p62 in cultured SH-SY5Y cells. Feeding reserpine dose-dependently shortened the lifespan and caused impairment of motor functions in male and female Drosophila. Moreover, long-term oral administration of reserpine led to multiple motor and non-motor symptoms, including constipation, pain hypersensitivity, olfactory impairment, and depression-like behaviors in mice. The mechanistic studies showed that chronic reserpine exposure caused hypomethylation of the alpha-synuclein gene and up-regulated its expression and elevated the ratio of LC3-II/LC3-Ⅰ and expression of p62 in the substantia nigra of mice. Thus, we established preclinical animal models using reserpine to recapitulate the motor and non-motor symptoms of PD. Chronic reserpine exposure epigenetically elevated the levels of alpha-synuclein expression possible by lowering the DNA methylation status and inducing autophagic impairment in vitro and in vivo.
Advances in the roles and mechanisms of lignans against Alzheimer’s disease
Authors: Han Na , Wen Yuanyuan , Liu Zhihui , Zhai Jianxiu , Li Sikai , Yin Jun
Published: October 2022

Background: Alzheimer’s disease (AD) is a serious neurodegenerative disease associated with the memory and cognitive impairment. The occurrence of AD is due to the accumulation of amyloid β-protein (Aβ) plaques and neurofibrillary tangles (NFTs) in the brain tissue as well as the hyperphosphorylation of Tau protein in neurons, doing harm to the human health and even leading people to death. The development of neuroprotective drugs with small side effects and good efficacy is focused by scientists all over the world. Natural drugs extracted from herbs or plants have become the preferred resources for new candidate drugs. Lignans were reported to effectively protect nerve cells and alleviate memory impairment, suggesting that they might be a prosperous class of compounds in treating AD.

Objective: To explore the roles and mechanisms of lignans in the treatment of neurological diseases, providing proofs for the development of lignans as novel anti-AD drugs.

Methods: Relevant literature was extracted and retrieved from the databases including China National Knowledge Infrastructure (CNKI), Elsevier, Science Direct, PubMed, SpringerLink, and Web of Science, taking lignan, anti-inflammatory, antioxidant, apoptosis, nerve regeneration, nerve protection as keywords. The functions and mechanisms of lignans against AD were summerized.

Results: Lignans were found to have the effects of regulating vascular disorders, anti-infection, anti-inflammation, anti-oxidation, anti-apoptosis, antagonizing NMDA receptor, suppressing AChE activity, improving gut microbiota, so as to strengthening nerve protection. Among them, dibenzocyclooctene lignans were most widely reported and might be the most prosperous category in the develpment of anti-AD drugs.

Conclusion: Lignans displayed versatile roles and mechanisms in preventing the progression of AD in in vitro and in vivo models, supplying potential candidates for the treatment of nerrodegenerative diseases.
Research advances in treatment methods and drug development for rare diseases
Authors: Han Qiaoqiao , Fu Hengtao , Chu Xiaoyue , Wen Ruixin , Zhang Miao , You Tao , Fu Peng , Qin Jian , Cui Tao
Published: October 2022

As the incidence of rare diseases increases each year, the total number of rare disease patients worldwide is nearly 400 million. Orphan medications are drugs used to treat rare diseases. Orphan drugs, however, are rare and patients often struggle to utilize them and expensive medications during treatment. Orphan drugs have been the focus of new drug research and development for both domestic and international pharmaceutical companies as a result of the substantial investment being made in the field of rare diseases. Clinical breakthroughs have been made in every field, from traditional antibodies and small molecule drugs to gene therapy, stem cell therapy and small nucleic acid drugs. We here review the therapeutic means of rare diseases and drug development of rare diseases to show the progress of treatment of rare diseases in order to provide a reference for clinical use and new drug development of rare diseases in China.
Shear-induced diffusion and dynamic heterogeneities in dense granular flows
Authors: Saitoh Kuniyasu , Kawasaki Takeshi
Published: October 2022

We study two-dimensional dense granular flows by molecular dynamics simulations. We quantify shear-induced diffusion of granular particles by the transverse component of particle displacements. In long time scales, the transverse displacements are described as normal diffusion and obey Gaussian distributions, where time correlations of particle velocities entirely vanish. In short time scales, the transverse displacements are strongly non-Gaussian if the system is dense and sheared quasistatically though memory effects on the particle velocities are further suppressed. We also analyze spatio-temporal structures of the transverse displacements by self-intermediate scattering functions and dynamic susceptibilities. We find that the relation between the maximum intensity and characteristic time scale for dynamic heterogeneities is dependent on the models of contact damping (which exhibit different rheological properties such as the Newtonian fluids’ behavior and shear thickening). In addition, the diffusion coefficient over the shear rate is linear (sub-linear) in the maximum of dynamic susceptibility if the damping force is not restricted (restricted) to the normal direction between the particles in contact.
Maximizing anaerobic performance with repeated-sprint training in hypoxia: In search of an optimal altitude based on pulse oxygen saturation monitoring
Authors: Gutknecht Alexandre P. , Gonzalez-Figueres Martin , Brioche Thomas , Maurelli Olivier , Perrey Stéphane , Favier François B.
Published: October 2022

Purpose: Repeated-sprint training in hypoxia (RSH) leads to great improvements in anaerobic performance. However, there is no consensus about the optimal level of hypoxia that should be used during training to maximize subsequent performances. This study aimed to establish whether such an optimal altitude can be determined and whether pulse oxygen saturation during RSH is correlated with training-induced improvement in performance.

Methods: Peak and mean power outputs of healthy young males [age (mean ± SD) 21.7 ± 1.4 years] were measured during a Wingate (30 s) and a repeated-sprint ability (RSA; 10 x 6-s sprint with 24-s recovery) test before and after RSH. Participants performed six cycling sessions comprising three sets of 8 x 6-s sprint with 24-s recovery in normobaric hypoxia at a simulated altitude of either 1,500 m, 2,100 m, or 3,200 m (n = 7 per group). Heart rate variability was assessed at rest and during recovery from Wingate test before and after RSH.

Results: The subjective rating of perceived exertion and the relative exercise intensity during training sessions did not differ between the three groups, contrary to pulse oxygen saturation (p < 0.001 between each group). Mean and peak power outputs were significantly increased in all groups after training, except for the mean power in the RSA test for the 3200 m group. Change in mean power on RSA test (+8.1 ± 6.6%) was the only performance parameter significantly correlated with pulse oxygen saturation during hypoxic training (p < 0.05, r = 0.44). The increase in LnRMSSD during recovery from the Wingate test was enhanced after training in the 1,500 m (+22%) but not in the two other groups (≈– 6%). Moreover, the increase in resting heart rate with standing after training was negatively correlated with SpO2 (p < 0.01, r =–0.63) suggesting that hypoxemia level during training differentially altered autonomic nervous system activity.

Conclusion: These data indicate that RSH performed as early as 1,500 m of altitude is effective in improving anaerobic performance in moderately trained subjects without strong association with pulse oxygen saturation monitoring during training.
Morphological and physiological changes induced by Achyranthes aspera-mediated silver nanocomposites in Aedes aegypti larvae
Authors: Sharma Aarti , Mishra Monika , Dagar Vinay Singh , Kumar Sarita
Published: October 2022

Aedes aegypti is responsible for the global spread of several ailments such as chikungunya, dengue, yellow fever, and Zika. The use of synthetic chemicals is the primary intervention in mosquito management. However, their excessive utilization resulting in the spread of toxic ingredients in the environment and posing threats to beneficial organisms has prompted the recommendation for the use of biologically synthesized nanocomposites as a promising approach for vector control. Silver nanocomposites were synthesized using leaf (AL-AgNCs) and stem (AS-AgNCs) extracts of Achyranthes aspera. The early fourth instars of A. aegypti were exposed to lethal doses of these nanocomposites to evaluate their effects on larval development, behavior, morphology, and mid-gut histoarchitecture. The cellular damage and deposition of nanocomposite residues in the mid-gut were studied using light and transmission electron microscopy. The A. aspera silver nanocomposite (AA-AgNC)-exposed larvae exhibited dose-dependent extended duration of development and diminished adult emergence, but did not exhibit modified behavior. Intense damage to the cuticle membrane and slight contraction in the internal membrane of anal papillae were noticed. Morphologically, the mid-gut appeared disorganized, darkly pigmented, and shrunk. Histological investigations of the mid-gut revealed significantly disordered internal architecture with lysed cells, damaged peritrophic membrane and microvilli, disintegrated epithelial layer, and a ruptured and displaced basement membrane. Visualization of the larval mid-gut through TEM showed severe cellular damage and aggregation of black spots, indicating the deposition of silver particles released by AA-AgNCs. The investigations revealed the bio-efficacy of A. aspera-mediated AgNCs against A. aegypti inducing stomach and contact toxicity in the larvae. The utilization of AA-AgNCs is recommended for A. aegypti management as a safe and effective intervention.
Infusion of an acidified ethanolic—dextrose solution enhances urinary ammonium excretion and increases acid resilience in non—mechanically ventilated acidotic rabbits
Authors: Walsh Patrick A.
Published: October 2022

Hitherto, the rabbit has long been known to have a very poor tolerance to non—volatile acid. In this study, we tested the hypothesis that acid resilience in the acidotic rabbit can be increased by enhancing the plasma availability of a naturally occurring volatile fatty acid, namely acetate. To ascertain the relative merits of the respiratory and renal systems in contributing to that resilience, we conducted our studies in non—ventilated and mechanically ventilated acidotic animals. Using ethanol as a feeder of acetate, and to counteract the antidiuretic effects of surgical interventions, we induced acidosis in anaesthetised rabbits, by intravenously infusing an acidified ethanolic dextrose solution. We observed very potent respiratory regulation of arterial blood pH coupled with a notable renal response by way of a 25-fold increase in urinary ammonium excretion in the non—ventilated group. In contrast, arterial blood pH plummeted much more rapidly in the mechanically—ventilated animals, but the compensated renal response was enormous, in the form of an 85 -fold increase in urinary ammonium output. Despite this significant adaptive renal response, the non -mechanically ventilated group of rabbits showed the greater acid resilience. This was attributed to an acetate stimulated flux through a series of metabolic pathways, generating supplementary buffer in the form of bicarbonate and ammonia, complemented by a robust respiratory response.
Transcriptomic and metabolomic profiling of strawberry during postharvest cooling and heat storage
Authors: Zheng Ting , Lv Jinhua , Sadeghnezhad Ehsan , Cheng Jianhui , Jia Haifeng
Published: October 2022

Temperature is one of the most important factors regarding fruit postharvest, however its effects in the strawberry fruits quality in postharvest remains to be evaluated. In this study, the effects of cold and heat storage temperature on fruit quality of ‘Benihoppe’ strawberry were performed. The results showed that different temperatures could affect the metabolism of hormone, anthocyanin, reactive oxygen species (ROS), and transcription level of responsive factors. The synthesis of terpenoids, amino acids, and phenylpropanoids in strawberries were also changed under different temperatures, which finally changed the quality characteristics of the fruit. We found HSF20 (YZ1)-overexpressed fruits were sensitive to cold and heat conditions but CBF/NF-Y (YZ9)-overexpressed fruits promoted coloring under cold treatment. This study clarified the effect of postharvest cooling and heat treatments on quality and transcriptional mechanism of strawberries fruits. Moreover, these results provided an experimental basis for further research on improving the quality of strawberry berries during postharvest periods.
A versatile Agrobacterium-based plant transformation system for genetic engineering of diverse citrus cultivars
Authors: Dominguez Michelle M. , Padilla Carmen S. , Mandadi Kranthi K.
Published: October 2022

Developing an efficient transformation system is vital in genetically engineering recalcitrant crops, particularly trees. Here, we outline an Agrobacterium tumefaciens-based stable plant transformation methodology for citrus genetic engineering. The process was optimized to suit the requirements of fourteen citrus varieties by establishing appropriate infection, co-cultivation, selection, and culture media conditions. The procedure includes transforming seedling-derived epicotyl segments with an A. tumefaciens strain, then selecting and regenerating transformed tissues. Transgenic shoots were further identified by a visual reporter (e.g., β-glucuronidase) and confirmed by Northern and Southern blot analysis. Transgene integrations among the transgenic lines ranged between one to four. The methodology can yield transformation efficiencies of up to 11%, and transgenic plants can be recovered as early as six months, depending on the variety. In addition, we show that incorporating A. tumefaciens helper virulence genes (virG and virE), spermidine, and lipoic acid in the resuspension buffer before transformation improved the transformation efficiency of specific recalcitrant cultivars, presumably by enhancing T-DNA integration and alleviating oxidative stress on the explant tissues. In conclusion, the optimized methodology can be utilized to engineer diverse recalcitrant citrus varieties towards trait improvement or functional genetics applications.
Temporal variations in root-associated fungal communities of Potaninia mongolica, an endangered relict shrub species in the semi-arid desert of Northwest China
Authors: Wang Yonglong , Xu Ying , Maitra Pulak , Babalola Busayo Joshua , Zhao Yanling
Published: October 2022

The semi-arid region of the Western Ordos plateau in Inner Mongolia, China, is home to a critically endangered shrub species, Potaninia mongolica, which originates from ancient Mediterranean regions. Root-associated microbiomes play important roles in plant nutrition, productivity, and resistance to environmental stress particularly in the harsh desert environment; however, the succession of root-associated fungi during the growth stages of P. mongolica is still unclear. This study aimed to examine root-associated fungal communities of this relict plant species across three seasons (spring, summer and autumn) using root sampling and Illumina Miseq sequencing of internal transcribed spacer 2 (ITS 2) region to target fungi. The analysis detected 698 fungal OTUs in association with P. mongolica roots, and the fungal richness increased significantly from spring to summer and autumn. Eurotiales, Hypocreales, Chaetothyriales, Pleosporales, Helotiales, Agaricales and Xylariales were the dominant fungal orders. Fungal community composition was significantly different between the three seasons, and the fungal taxa at various levels showed biased distribution and preferences. Stochastic processes predominantly drove community assembly of fungi in spring while deterministic processes acted more in the later seasons. The findings revealed the temporal dynamics of root-associated fungal communities of P. mongolica, which may enhance our understanding of biodiversity and changes along with seasonal alteration in the desert, and predict the response of fungal community to future global changes.
Detecting strawberry diseases and pest infections in the very early stage with an ensemble deep-learning model
Authors: Lee Sangyeon , Arora Amarpreet Singh , Yun Choa Mun
Published: October 2022

Detecting early signs of plant diseases and pests is important to preclude their progress and minimize the damages caused by them. Many methods are developed to catch signs of diseases and pests from plant images with deep learning techniques, however, detecting early signs is still challenging because of the lack of datasets to train subtle changes in plants. To solve these challenges, we built an automatic data acquisition system for the accumulation of a large dataset of plant images and trained an ensemble model to detect targeted plant diseases and pests. After obtaining 13,393 plant image data, our ensemble model shows a decent detection performance with an average of AUPRC 0.81. Also, this data acquisition and the detection process can be applied to other plant anomalies with the collection of additional data.
Reducing the influence of perfectionism and statistics anxiety on college student performance in statistics courses
Authors: Wu Rongjun , Chen Juan , Li Qi , Zhou Hongcang
Published: October 2022

The influence of perfectionism and statistics anxiety on academic performance (AP) in statistics courses was investigated using a multidimensional perfectionism scale and a statistics anxiety rating scale. For perfectionism, the factor of personal standards (PS) had a significant direct positive effect on AP, while the factor of parental expectations (PE) was significantly negatively correlated with AP. Other factors (concern over mistakes, organization, and doubts about actions) did not significantly influence AP. For statistics anxiety, the two factors (test and class anxiety and computation self-concept) significantly impaired AP. These results indicated a need for innovation in classroom instruction and the reform of statistics course content and presentation to reduce statistics anxiety and improve PS. There is also a need to ensure that students better internalize PE and to revise instructional design techniques to enhance students’ independent learning ability.
From entrepreneurial passion to business model innovation: The role of entrepreneurial learning and curiosity
Authors: Zou Shuli
Published: October 2022

The impact of entrepreneurial passion on business model innovation has become a research focus in the field of entrepreneurship. This study aimed to examine the effect of entrepreneurial passion on entrepreneurial learning and business model innovation. The study used partial least square-structural equation modeling (PLS-SEM 4) to test the hypotheses on a sample of 389 manufacturing and technology enterprises in the South region of Henan province China. The results of this study revealed that entrepreneurial passion has a positive and significant influence on entrepreneurial learning and business model innovation. The findings of this study showed that entrepreneurial learning positively and significantly mediates the relationship between entrepreneurial passion and business model innovation. Furthermore, the results of this study indicated that curiosity positively and significantly moderates the relationship between entrepreneurial passion and entrepreneurial learning. Lastly, the results are discussed with implications and limitations, which open up future research perspectives.
Insuppressible cognitions in the reflexive imagery task: Insights and future directions
Authors: Yankulova Jessica K. , Zacher Lisa Moreno , Velasquez Anthony G. , Dou Wei , Morsella Ezequiel
Published: October 2022

In 1959, Neal Miller made the bold claim that the Stimulus–Response, Behaviorist models of that era were describing the way in which stimuli lead to the entry of contents into consciousness (“entry,” for short). Today, researchers have begun to investigate the link between external stimuli and involuntary entry, using paradigms such as the reflexive imagery task (RIT), the focus of our review. The RIT has revealed that stimuli can elicit insuppressible entry of high-level cognitions. Knowledge of the boundary conditions of the RIT effect illuminates the limitations of involuntary processes and the role of consciousness in the regulation of behavior. We review the boundary conditions of this paradigm as well as its systematic effects. Systematic effects are unlikely to be due to experimental demand. While reviewing each effect, we consider its theoretical implications. In addition, throughout our review, we discuss future directions for the study of insuppressible entry using the RIT. Last, we discuss a theoretical development (passive frame theory) that stems from the RIT and illuminates how involuntary entry and encapsulation, though at times disadvantageous for the actor, are essential for adaptiveaction selectionduring the course of ontogeny.
The psychological impact of the COVID emergency on Italian nursing homes staff and the effectiveness of eye movement desensitization and reprocessing
Authors: Faretta Elisa , Maslovaric Giada , Garau M. Ignazia , Marmondi Gabriella , Piras Laura , Rezzola Simona , Incerti Alessia , Nardoni Anna , Pagani Marco , Gallina Eugenio
Published: October 2022

Residential nursing homes were particularly badly affected by the first wave of COVID-19, with large numbers of their frail person getting infected with COVID-19 and dying. The staff in these structures were catapulted into a reality very different from what they were used to. They had to adapt the way they used to take care of their patients in a very short space of time and in a scenario that was continually changing. In this manuscript we describe the subjective experience of staff in a number of Italian nursing homes during the first wave of the COVID-19 pandemic; and we report data showing the effectiveness of the Eye Movement Desensitization and Reprocessing (EMDR) treatment provided to support them during this Pandemic.
Parenting and mobile phone addiction tendency of Chinese adolescents: The roles of self-control and future time perspective
Authors: Peng Yuan , Wang Yali , Liu Shaozhuo , Hu Xingzhao
Published: October 2022

Previous studies examined the impact of parenting on adolescents' mobile phone addiction tendencies. However, relatively few studies examined the potential mechanism underlying such a relationship. Thus, the present study further explored the mediation effect of self-control and the moderating effect of future time perspective between parenting and mobile phone addiction tendencies of Chinese adolescents. A sample of 1,349 Chinese adolescents (Mage = 15. 22 years, SD = 0.79) responded to the anonymous questionnaires regarding parenting, including parental control and parental care, self-control, future time perspective, and mobile phone addiction tendency. The results showed that (1) parental control was positively related to adolescents' mobile phone addiction tendencies, while parental care was negatively related to adolescents' mobile phone addiction tendencies; (2) self-control could mediate the pathway from both parental control and parental care to adolescents' mobile phone addiction tendencies; and (3) the indirect pathway could be moderated by future time perspective. Specifically, a high future time perspective combined with high self-control predicted a low level of mobile phone addiction tendency. In contrast, low self-control was associated with a high tendency toward mobile phone addiction, regardless of their future time perspective. The present study revealed a complex interplay between family and individual factors contributing to adolescents' mobile phone addiction tendencies.
Baclofen in alcohol use disorder: An analysis of the data provided by the French “Temporary Recommendation for Use” 2014–2017 cohort
Authors: de Beaurepaire Renaud , Rolland Benjamin
Published: October 2022

Alcohol use disorder (AUD) is a devastating illness for which effective treatments are lacking. Studies over the last two decades have shown that baclofen, a GABA-B agonist, could be a promising treatment for AUD. However, the efficacy of baclofen is still controversial, and studies have shown that it may be associated with an excess of hospitalizations and deaths. In March 2014, the French Health Safety Agency granted a “Temporary Recommendation for Use” (TRU) regulating the prescription of baclofen in subjects with AUD. The TRU allowed physicians to prescribe high-dose baclofen (up to 300 mg/d). The doses were adjusted, and tailored to the needs of each patient. Between March 2014 and March 2017, TRU clinical data were collected for a total of 6,939 subjects. The recorded data included information on alcohol consumption, the intensity of alcohol cravings, and adverse events. The present article proposes an analysis of the data provided by the TRU. Subjects for which data were missing regarding baclofen daily dosage, alcohol consumption or craving scores were discarded from the analyses. A cohort of two groups of subjects was analyzed. The first group included all TRU subjects suitable for analyses (5,550 subjects), and the second group included subjects followed for at least 365 days (169 subjects). Comparisons were made between baseline and endpoint of the follow-up period. The results show that a majority of subjects in the whole cohort had received doses of over 80 mg/d. The mean dose of baclofen at the endpoint was >110 mg/d in the second group of subjects. Doses of >80 mg/d were not associated with an increase in adverse events after adjustment for the follow-up duration. In terms of efficacy, comparisons between baseline and endpoint show that baclofen treatment significantly decreased alcohol consumption and alcohol cravings, and significantly increased the number of subjects with null or low-risk alcohol consumption according to WHO criteria.
Short-term exposure to ambient fine particulate matter and psoriasis: A time-series analysis in Beijing, China
Authors: Wu Junhui , Chen Hongbo , Yang Ruotong , Yu Huan , Shang Shaomei , Hu Yonghua
Published: October 2022

Background

Ambient fine particulate matter (PM2.5) adversely affects human health and has been linked to a variety of skin disorders. However, little is known about the effects of PM2.5 on psoriasis.

Methods

The Beijing Medical Claim Data for Employees database recorded 500,266 outpatient visits for psoriasis during 2010–2017. A generalized additive quasi-Poisson model was used to examine the relationship between daily PM2.5 concentrations and outpatient visits for psoriasis with stratification by sex, age, and season.

Results

Short-term exposure to PM2.5 was associated with outpatient visits for psoriasis-related health concerns. A same-day increase of 10 μg/m3 in PM2.5 concentrations was associated with a 0.29% (95% confidence interval: 0.26–0.32%) increase in daily outpatient visits for psoriasis. Female and older patients appeared to be more sensitive to the effects of PM2.5 (P < 0.05).

Conclusions

Short-term elevations in PM2.5 concentrations may be associated with exacerbations in psoriasis. Further work is warranted to confirm the findings and elucidate the underlying biological mechanisms.
SEIR model and simulation research on unsafe psychological state propagation of construction workers considering safety climate and intimate relationships
Authors: Yuan Ruijia , Zhang Zhiwei , Deng Xiaopeng , Li Xiaosheng
Published: October 2022

The construction industry is a pillar industry of China and occupies an essential position in our economic development. However, in the fast-developing construction industry, the number of its safety accidents is also growing year by year. Safety accidents are often due to unsafe behaviors of construction workers, and unsafe precarious psychological states are important factors for unsafe behaviors. Therefore, this paper, based on a review of existing literature, uses the SEIR model and numerical simulation method to study the spread of unsafe psychological states among construction workers considering safety climate and intimate relationships. It puts forward corresponding countermeasures, which has great practical significance for reducing safety accidents in the construction industry. The results show that: (1) A good safety climate can help alleviate the spread of unsafe psychological states of construction workers. (2) The intimate relationship between construction workers will promote the association between communicable people and susceptible people, which will lead to the spread of an unsafe psychological state. (3) A larger network average degree will increase the spread speed and the density of communicable people, but will not increase the spread range.(4) Forgetting rate has a key role in the propagation of unsafe psychological states. Suggestions are made to hinder the propagation of these states, which will help to reduce the unsafe behavior of construction workers and the accident rate in the construction industry.
Linkage to care and treatment among men with reactive HIV self-tests after workplace-based testing in Uganda: A qualitative study
Authors: Muwanguzi Patience A. , Nelson LaRon E. , Ngabirano Tom D. , Kiwanuka Noah , Osingada Charles Peter , Sewankambo Nelson K.
Published: October 2022

Introduction

HIV self-testing at workplaces has the potential to reach men at risk of HIV infection with lower access to HIV testing services. While several studies have reported high uptake of HIV self-testing, linkage to HIV care following a positive result remains a challenge. This study, therefore, explored the motivators for and barriers to linkage to HIV care and treatment among men who returned positive results following workplace-based HIV self-testing.

Methods

A qualitative descriptive study, among men in private security services in Kampala district, Uganda. The men were eligible to participate if they were aged 18 to 60 years and had worked at the company for more than 6 months. Following HIV self-testing, participants with reactive (positive) self-test results were purposively sampled and engaged in key informant interviews. Inductive content analysis was employed to identify the motivators and barriers to the men's linkage to HIV treatment and care.

Results

Overall, 12 men participated in the study, of whom 9 (75%) were security guards, and the rest held management positions. The motivators for linkage to care coalesced under five categories. (i) Communication (open communication, phone reminders, consistent communication) (ii) Navigating health facility systems and processes (enabling health facility environment, easy access to health care, employing ART clinic counselors as part of the study team, health workers) (iii) Linkage support (linkage companions, referral forms, linkage facilitation, individualized linkage plan, pre-arranged clinic appointments) (iv) Psychosocial support (counseling sessions, family support, online and social media support, peer support) (v) workplace environment (employer's support, work schedules and policies). The barriers to linkage to HIV care included (i) Inflexible work schedules, (ii) Far distances to travel to access ART (iii) mandatory work transfers, (iv) disruptive effects of the COVID-19 pandemic, (v) Denial of HIV-positive results and (vi) fear of stigma and discrimination at health facilities.

Conclusion

The findings suggest the need for innovative interventions to facilitate regular follow-up and open communication with workplace-based HIV self-testers, to improve linkage to HIV care and treatment. Furthermore, initiating linkage plans during pre-test counseling and working in collaboration with health facilities and clinics may improve linkage to care.
A protocol for applying health equity-informed implementation science models and frameworks to adapt a sleep intervention for adolescents at risk for suicidal thoughts and behaviors
Authors: Williamson Ariel A. , Soehner Adriane M. , Boyd Rhonda C. , Buysse Daniel J. , Harvey Allison G. , Jonassaint Charles R. , Franzen Peter L. , Goldstein Tina R.
Published: October 2022

Background

Effective and equitable strategies to prevent youth suicidal thoughts and behaviors (STB) are an urgent public health priority. Adolescent sleep disturbances are robustly linked to STB but are rarely addressed in preventive interventions or among Black and/or Hispanic/Latinx youth for whom STB risk is increasing disproportionately. This paper describes an application of health equity-informed implementation science models and frameworks to adapt and evaluate the evidence-based Transdiagnostic Sleep and Circadian (TSC) intervention for primary care implementation with adolescents of minoritized backgrounds with depression and STB risk.

Methods

This multiphase study protocol uses the Assessment, Decision, Adaptation, Production, Topical Experts-Integration, Training, Testing (ADAPT-ITT) model to adapt and evaluate TSC for primary care implementation with adolescents who are depressed, at risk for STB, and of primarily Black and/or Hispanic/Latinx backgrounds. We integrate the Consolidated Framework for Implementation Research (CFIR) in an initial qualitative inquiry of adolescent, caregiver, and clinician perceptions of TSC. Subsequent ADAPT-ITT phases include systematically and iteratively testing adaptations based on the qualitative inquiry, with ongoing key informant input, and then evaluating the adapted TSC for feasibility, acceptability, and efficacy in a pilot randomized trial.

Anticipated results

Based on youth depression and sleep health disparities research, we expect that TSC adaptations will be needed to enhance intervention content for adolescents with depression, STB risk, and primarily Black and/or Hispanic/Latinx backgrounds. We also anticipate adaptations will be needed to align TSC delivery methods with primary care implementation.

Conclusions

Adapting evidence-based interventions with end-users and contexts in mind can help ensure that intervention strategies and delivery methods are acceptable to, and feasible with, health disparate populations. Although TSC has shown effectiveness for adolescents with sleep disturbances, we expect that additional multiphase research is necessary to optimize TSC for primary care delivery with Black and/or Hispanic/Latinx adolescents with depression and STB risk.
Effect of the full coverage policy of essential medicines on medication adherence: A quasi-experimental study in Taizhou, China
Authors: Guo Zhigang , He Zixuan , Li Huangqianyu , Zheng Liguang , Shi Luwen , Guan Xiaodong
Published: October 2022

Objective

Different forms of full coverage policy of essential medicines (FCPEMs) have been adopted worldwide to lower medication expenditure and improve adherence. This study aims to analyse the effect of FCPEMs on patients' medication adherence in Taizhou city, China.

Methods

This study was a quasi-experimental study and set treatment and control groups. We extracted Electronic Health Records (EHRs) for hypertension and diabetes 1 year before and after FCPEMs implementation and their medication adherence level assessed by physicians. We applied the propensity score matching (PSM) method to balance the bias between the two groups. Then, the descriptive analysis was used to compare the differences in the reported medication adherence. Using the Difference-In-Differences (DIDs) method, the fixed-effect model with the logistic regression was built to analyse the effects of FCPEMs.

Results

225,081 eligible patients were identified from the original database. In the baseline year, FCPEM covered 39,251 patients. After PSM, 6,587 patients in the treatment group and 10,672 patients in the control group remained. We found that the proportion of patients with high adherence in the treatment group increased by 9.1% (60.8 to 69.9%, P < 0.001) and that in the control group increased by 2.6% (62.5 to 65.2%, P < 0.001). The regression results showed that FCPEMs significantly increased patients' medication adherence (OR = 2.546, P < 0.001).

Conclusion

FCPEMs significantly improved medication adherence. Socially disadvantaged individuals might benefit more from continuing FCPEM efforts. Expanding the coverage of FCPEMs to other medicines commonly used in patients with chronic diseases may be a promising strategy to manage chronic diseases and promote patient outcomes.
Creating an empirically-based model of social arts as a public health resource: Training, typology, and impact
Authors: Shefi Noa , Orkibi Hod , Huss Ephrat
Published: October 2022

Introduction

Mounting empirical evidence underscores the health benefits of the arts, as recently reported in a scoping review by the World Health Organization. The creative arts in particular are acknowledged to be a public health resource that can be beneficial for well-being and health. Within this broad context, and as a subfield of participatory arts, the termsocial arts(SA) specifically refers to an art made by socially engaged professionals (e.g., artists, creative arts therapists, social workers, etc.) with non-professionals who determine together the content and the final art product (in theater, visual arts, music, literature, etc.) with the aim to produce meaningful social changes. SA can enhance individual, community, and public health in times of sociopolitical instability and is an active field in Israel. However, SA is still an under-investigated field of study worldwide that is hard to characterize, typify, or evaluate. This paper presents a research protocol designed to examine a tripartite empirically-based model of SA that will cover a wide range of SA training programs, implementations, and impacts. The findings will help refine the definition of SA and inform practitioners, trainers, and researchers, as well as funding bodies and policymakers, on the content and impact of SA projects in Israel and beyond.

Methods and analysis

This 3-stage mixed methods study will be based on the collection of primary qualitative and arts-based data and secondary, complementary, quantitative data. Triangulation and member checking procedures will be conducted to strengthen the trustworthiness of the findings obtained from different stakeholders.

Discussion

Growing interest in the contribution of arts to individual and public health underscores the importance of creating an empirically grounded model for SA. The study was approved by the university ethics committee and is supported by the Israel Science Foundation. All participants will sign an informed consent form and will be guaranteed confidentiality and anonymity. Data collection will be conducted in the next 2 years (2022 to 2024). After data analysis, the findings will be disseminatedviapublications and conferences.
Shortcomings of applying data science to improve professional football performance: Takeaways from a pilot intervention study
Authors: Herold Mat , Kempe Matthias , Ruf Ludwig , Guevara Luis , Meyer Tim
Published: October 2022

Positional tracking data allows football practitioners to derive features that describe patterns of player behavior and quantify performance. Existing research using tracking data has mostly focused on what occurred on the pitch, such as the determinants of effective passing. There have yet to be studies attempting to use findings from data science to improve performance. Therefore, 24 professional players (mean age = 21.6 years, SD = 5.7) were divided into a control team and an intervention team which competed against each other in a pre-test match. Metrics were gathered via notational analysis (number of passes, penalty box entries, shots on goal), and positional tracking data including pass length, pass velocity, defensive disruption (D-Def), and the number of outplayed opponents (NOO). D-Def and NOO were used to extract video clips from the pre-test that were shown to the intervention team as a teaching tool for 2 weeks prior to the post-test match. The results in the post-test showed no significant improvements from the pre-test between the Intervention Team and the Control Team for D-Def (F = 1.100, p = 0.308, η2 = 0.058) or NOO (F = 0.347, p = 0.563, η2 = 0.019). However, the Intervention Team made greater numerical increases for number of passes, penalty box entries, and shots on goal in the post-test match. Despite a positive tendency from the intervention, results indicate the transfer of knowledge from data science to performance was lacking. Future studies should aim to include coaches' input and use the metrics to design training exercises that encourage the desired behavior.