bluuebunny/crossref_metadata_2025 huggingface dataset:
Willingness of postmenopausal women to participate in a study involving local vaginal oestrogen treatment as an adjunct to pelvic organ prolapse surgery: a qualitative study
Authors: Verghese Tina Sara , Merriel Abigail , Leighton Lisa , Latthe Pallavi
Published: August 2020

Background

Pelvic organ prolapse (POP) negatively affects many women’s quality of life. The ability to develop improved therapeutic approaches for POP patients is hampered by low patient recruitment and retention rates in clinical trials.

Objective

Our objective was to explore the motivational factors and barriers to recruitment and participation in clinical trials among postmenopausal women with POP who are intending to have surgical management.

Design

Qualitative study based on in-depth face-to-face interviews with postmenopausal women attending urogynaecology clinics in the UK intending to have surgical management for pelvic organ prolapse. These women were eligible to participate in the on-going clinical trial on the use of local vaginal oestrogen as an adjunct to surgical treatment. Twenty-two postmenopausal women aged 52–76 years were interviewed. Interviews were analysed using thematic analysis method.

Results

Many women participated because of altruistic motivations; however, we found that clarity of information provided, timing of approach and acceptability of study design played a pivotal role in women. Of the women who declined participation, the following themes emerged: uncertainty of the investigational product, fear of experimentation, logistical concerns and regret that their condition was trivialised at an early stage.

Conclusion

We have gained a valuable insight into women’s views and experience in the decision making process. Understanding the elements that will enhance trial participation such as clarity of information provided, balance between professional guidance whilst maintaining equipoise, easy access to trial teams and timing of approach will ultimately enable us to improve our recruitment to clinical trials.
Implementation of robotic gynecological surgery in a German University Hospital: patient safety after 110 procedures
Authors: Balafoutas Dimitrios , Wöckel Achim , Wulff Christine , Joukhadar Ralf
Published: August 2020

Purpose

Robotic surgery represents the latest development in the field of minimally invasive surgery and offers many technical advantages. Despite the higher costs, this novel approach has been applied increasingly in gynecological surgery. Regarding the implementation of a new operative method; however, the most important factor to be aware of is patient safety. In this study, we describe our experience in implementing robotic surgery in a German University Hospital focusing on patient safety after 110 procedures.

Methods

We performed a retrospective analysis of 110 consecutive robotic procedures performed in the University Hospital of Würzburg between June 2017 and September 2019. During this time, 37 patients were treated for benign general gynecological conditions, 27 patients for gynecological malignancies, and 46 patients for urogynecological conditions. We evaluated patient safety through standardized assessment of intra- and postoperative complications, which were categorized according to the Clavien–Dindo classification.

Results

No complications were recorded in 90 (81.8%) operations. We observed Clavien–Dindo grade I complications in 8 (7.3%) cases, grade II complications in 5 (4.5%) cases, grade IIIa complications in 1 case (0.9%), and grade IIIb complications in 6 (5.5%) cases. No conversion to laparotomy or blood transfusion was needed.

Conclusion

Robotic surgery could be implemented for complex gynecological operations without relevant problems and was accompanied by low complication rates.
Tight Bounds for Online Coloring of Basic Graph Classes
Authors: Albers Susanne , Schraink Sebastian
Published: August 2020

We resolve a number of long-standing open problems in online graph coloring. More specifically, we develop tight lower bounds on the performance of online algorithms for fundamental graph classes. An important contribution is that our bounds also hold for randomized online algorithms, for which hardly any results were known. Technically, we construct lower bounds for chordal graphs. The constructions then allow us to derive results on the performance of randomized online algorithms for the following further graph classes: trees, planar, bipartite, inductive, bounded-treewidth and disk graphs. It shows that the best competitive ratio of both deterministic and randomized online algorithms is $$\Theta (\log n)$$

Θ
(
log
n
)

, where n is the number of vertices of a graph. Furthermore, we prove that this guarantee cannot be improved if an online algorithm has a lookahead of size $$O(n/\log n)$$

O
(
n
/
log
n
)

or access to a reordering buffer of size $$n^{1-\epsilon }$$

n

1
-
ϵ

, for any $$0<\epsilon \le 1$$

0
<
ϵ
≤
1

. A consequence of our results is that, for all of the above mentioned graph classes except bipartite graphs, the natural First Fit coloring algorithm achieves an optimal performance, up to constant factors, among deterministic and randomized online algorithms.
Oxygen reactivity with pyridoxal 5′-phosphate enzymes: biochemical implications and functional relevance
Authors: Bisello Giovanni , Longo Carmen , Rossignoli Giada , Phillips Robert S. , Bertoldi Mariarita
Published: August 2020

The versatility of reactions catalyzed by pyridoxal 5′-phosphate (PLP) enzymes is largely due to the chemistry of their extraordinary catalyst. PLP is necessary for many reactions involving amino acids. Reaction specificity is controlled by the orientation of the external aldimine intermediate that is formed upon addition of the amino acidic substrate to the coenzyme. The breakage of a specific bond of the external aldimine gives rise to a carbanionic intermediate. From this point, the different reaction pathways diverge leading to multiple activities: transamination, decarboxylation, racemization, elimination, and synthesis. A significant novelty appeared approximately 30 years ago when it was reported that some PLP-dependent decarboxylases are able to consume molecular oxygen transforming an amino acid into a carbonyl compound. These side paracatalytic reactions could be particularly relevant for human health, also considering that some of these enzymes are responsible for the synthesis of important neurotransmitters such as γ-aminobutyric acid, dopamine, and serotonin, whose dysregulation under oxidative conditions could have important implications in neurodegenerative states. However, the reactivity of PLP enzymes with dioxygen is not confined to mammals/animals. In fact, some plant PLP decarboxylases have been reported to catalyze oxidative reactions producing carbonyl compounds. Moreover, other recent reports revealed the existence of new oxidase activities catalyzed by new PLP enzymes, MppP, RohP, Ind4, CcbF, PvdN, Cap15, and CuaB. These PLP enzymes belong to the bacterial and fungal kingdoms and are present in organisms synthesizing bioactive compounds. These new PLP activities are not paracatalytic and could only scratch the surface on a wider and unexpected catalytic capability of PLP enzymes.
Stereoscopic 3D dashboards
Authors: Weidner Florian , Broll Wolfgang
Published: August 2020

When operating a conditionally automated vehicle, humans occasionally have to take over control. If the driver is out of the loop, a certain amount of time is necessary to gain situation awareness. This work evaluates the potential of stereoscopic 3D (S3D) dashboards for presenting smart S3D take-over-requests (TORs) to support situation assessment. In a driving simulator study with a 4 × 2 between-within design, we presented 3 smart TORs showing the current traffic situation and a baseline TOR in 2D and S3D to 52 participants doing the n-back task. We further investigate if non-standard locations affect the results. Take-over performance indicates that participants looked at and processed the TORs’ visual information and by that, could perform more safe take-overs. S3D warnings in general, as well as warnings appearing at the participants’ focus of attention and warnings at the instrument cluster, performed best. We conclude that visual warnings, presented on an S3D dashboard, can be a valid option to support take-over while not increasing workload. We further discuss participants’ gaze behavior in the context of visual warnings for automotive user interfaces.
Consistent change propagation within models
Authors: Kretschmer Roland , Khelladi Djamel Eddine , Lopez-Herrejon Roberto Erick , Egyed Alexander
Published: August 2020

Developers change models with clear intentions—e.g., for refactoring, defects removal, or evolution. However, in doing so, developers are often unaware of the consequences of their changes. Changes to one part of a model may affect other parts of the same model and/or even other models, possibly created and maintained by other developers. The consequences are incomplete changes and with it inconsistencies within or across models. Extensive works exist on detecting and repairing inconsistencies. However, the literature tends to focus on inconsistencies as errors in need of repairs rather than on incomplete changes in need of further propagation. Many changes are non-trivial and require a series of coordinated model changes. As developers start changing the model, intermittent inconsistencies arise with other parts of the model that developers have not yet changed. These inconsistencies are cues for incomplete change propagation. Resolving these inconsistencies should be done in a manner that is consistent with the original changes. We speak of consistent change propagation. This paper leverages classical inconsistency repair mechanisms to explore the vast search space of change propagation. Our approach not only suggests changes to repair a given inconsistency but also changes to repair inconsistencies caused by the aforementioned repair. In doing so, our approach follows the developer’s intent where subsequent changes may not contradict or backtrack earlier changes. We argue that consistent change propagation is essential for effective model-driven engineering. Our approach and its tool implementation were empirically assessed on 18 case studies from industry, academia, and GitHub to demonstrate its feasibility and scalability. A comparison with two versioned models shows that our approach identifies actual repair sequences that developers had chosen. Furthermore, an experiment involving 22 participants shows that our change propagation approach meets the workflow of how developers handle changes by always computing the sequence of repairs resulting from the change propagation.
Enzymatic processing of lignocellulosic biomass: principles, recent advances and perspectives
Authors: Østby Heidi , Hansen Line Degn , Horn Svein J , Eijsink Vincent G H , Várnai Anikó
Published: August 2020

Efficient saccharification of lignocellulosic biomass requires concerted development of a pretreatment method, an enzyme cocktail and an enzymatic process, all of which are adapted to the feedstock. Recent years have shown great progress in most aspects of the overall process. In particular, increased insights into the contributions of a wide variety of cellulolytic and hemicellulolytic enzymes have improved the enzymatic processing step and brought down costs. Here, we review major pretreatment technologies and different enzyme process setups and present an in-depth discussion of the various enzyme types that are currently in use. We pay ample attention to the role of the recently discovered lytic polysaccharide monooxygenases (LPMOs), which have led to renewed interest in the role of redox enzyme systems in lignocellulose processing. Better understanding of the interplay between the various enzyme types, as they may occur in a commercial enzyme cocktail, is likely key to further process improvements.
Effects of Biogas Composition on the Edge Flame Propagation in Igniting Turbulent Mixing Layers
Authors: Turquand d’Auzay C. , Papapostolou V. , Chakraborty N.
Published: August 2020

Three-dimensional compressible Direct Numerical Simulations have been used to investigate the localised forced ignition of statistically planar biogas/air mixing layers for different levels of turbulence intensity and biogas composition. The biogas is represented by a $$\hbox {CH}_4$$

CH
4

/$$\hbox {CO}_2$$

CO
2

mixture and a two-step mechanism capturing the variation of the unstrained laminar flame speed with equivalence ratio and $$\hbox {CO}_2$$

CO
2

dilution was used. The mixture composition was found to significantly affect the flame kernel development which was reflected in the diminished growth rate of the burned gas volume with increasing $$\hbox {CO}_2$$

CO
2

dilution. A successful ignition of $$\hbox {CH}_4$$

CH
4

/$$\hbox {CO}_2$$

CO
2

/air mixing layer gives rise to a tribrachial flame structure involving fuel-rich and lean premixed branches on either side of the diffusion flame stabilised on the stoichiometric mixture fraction iso-surface. The most probable edge flame speed decreases in time and converges to a value that is at most equal to its laminar theoretical limit, and can even locally become negative for large values of the dilution and/or turbulence intensity. The decomposition of the edge flame speed showed a negligible or negative contribution of the mixture fraction surface displacement speed, while the displacement speed of the fuel mass fraction surface appeared as the dominant contributor. Finally, the edge flame speed dependences to the fuel mass fraction and mixture fraction gradients, fuel mass fraction iso-surface curvature and tangential strain rate have been analysed and found, within the dilution values considered, qualitatively similar to those of undiluted mixtures regardless of the amount of $$\hbox {CO}_2$$

CO
2

, although quantitative differences were observed.
Are moral norms rooted in instincts? The sibling incest taboo as a case study
Authors: Cofnas Nathan
Published: August 2020

According to Westermarck’s widely accepted explanation of the incest taboo, cultural prohibitions on sibling sex are rooted in an evolved biological disposition to feel sexual aversion toward our childhood coresidents. Bernard Williams posed the “representation problem” for Westermarck’s theory: the content of the hypothesized instinct (avoid sex withchildhood coresidents) is different from the content of the incest taboo (avoid sex withsiblings)—thus the former cannot be causally responsible for the latter. Arthur Wolf posed the related “moralization problem”: the instinct concerns personal behavior whereas the prohibition concerns everyone. This paper reviews possible ways of defending Westermarck’s theory from the representation and moralization problems, and concludes that the theory is untenable. A recent study purports to support Westermarck’s account by showing that unrelated children raised in the same peer groups on kibbutzim feel sexual aversion toward each other and morally oppose third-party intra-peer-group sex, but this study has been misinterpreted. I argue that the representation and moralization problems aregeneralproblems that could potentially undermine many popular evolutionary explanations of social/moral norms. The cultural evolution of morality is not tightly constrained by our biological endowment in the way some philosophers and evolutionary psychologists believe.
The Dynamics of Thefts and Robberies in São Paulo’s Metro, Brazil
Authors: Ceccato Vania , Moreira Gustavo
Published: August 2020

The aim of this study is to assess the nature and space-temporal dynamics of property crimes (theft and robbery) in transport nodes, namely, metro stations and their immediate surrounding areas. The analysis is based on crime data over São Paulo’s metro system from 2010 to 2017. Drawing from environmental criminology theory, the methodology combines geographical information system (GIS) as well as statistical analysis using hypothesis testing and negative binomial regression models. Results show that thefts happen more often inside the station and robberies outside, with signs of possible interaction between these environments. Crime is often highly concentrated in a few inner city and end stations, but it varies depending on location and time. Future research and policy implications of the results add to the contribution of this current study.
Measuring sustainability in healthcare: an analysis of two systems providing insoles to patients with diabetes
Authors: Hellstrand Stefan , Sundberg L. , Karlsson J. , Zügner R. , Tranberg R. , Hellstrand Tang Ulla
Published: August 2020

There is an increasing demand to quantify the footprints, ecological, economic and social, in terms of the effect of different interventions in healthcare. The aim of this study was to compare two systems providing patients with diabetes with insoles in terms of their ecological, economic and social footprints. Prefabricated insoles (PRI) were compared with custom-made insoles (CMI). Using a welfare-economic monetary approach, costs were estimated for (1) treatment, (2) travelling to and from the hospital in terms of both fuel and time consumed by the patients and (3) society through emissions contributing to climate change. The proportion of patients/year that could be supplied within the same budget, for each individual treatment, was calculated. The cost of the insoles was 825 SEK (PRI) and 1450 SEK (CMI), respectively. The cost, mean value/patient due to the consumption of patients’ time at the department, was 754 SEK (PRI) and 1508 SEK (CMI), respectively. Emissions, in terms of CO2 equivalent, were 13.7 (PRI) and 27.4 (CMI), respectively. Using PRI, a total of 928 patients could be provided/year compared with 500 patients if CMI are used. By using PRI, the cost/treatment was reduced by 46%. The cost of treatment dominated and the cost of time consumed by patients were also substantial. The societal cost of contributing to climate change was of low importance. By using PRI, the needs of 86% more patients could be met within the same budget. Using these methods, the contribution of healthcare systems to the 17 Sustainable Development Goals approved by the UN can be quantified.
Vātsyāyana’s Guide to Liberation
Authors: Das Nilanjan
Published: August 2020

In this essay, my aim is to explain Vātsyāyana’s solution to a problem that arises for his theory of liberation. For him and most Nyāya philosophers after him, liberation consists in the absolute cessation of pain (ātyantika-duḥkha-vimukti). Since this requires freedom from embodied existence, it also results in the absolute cessation of pleasure. How, then, can agents like us (who habitually seek pleasure) be rationally motivated to seek liberation? Vātsyāyana’s solution depends on what I will call the Pain Principle, i.e., the principle that we should treat all aspects of our embodied existence as pain. If we were to follow this advice, we would come to apply the label of pain (duḥkha-saṃjñā) to all aspects of our embodied existence, including pleasure. This would undermine our attachment to our own embodied existence. I show that this fits with Vātsyāyana’s general theory of motivation. According to this theory, by manipulating the labels (saṃjñā) using which we think about the world and ourselves, we can induce radical shifts in our patterns of motivation.
Legal proof and statistical conjunctions
Authors: Ross Lewis D.
Published: August 2020

A question, long discussed by legal scholars, has recently provoked a considerable amount of philosophical attention: ‘Is it ever appropriate to base a legal verdict on statistical evidence alone?’ Many philosophers who have considered this question reject legal reliance on bare statistics, even when the odds of error are extremely low. This paper develops a puzzle for the dominant theories concerning why we should eschew bare statistics. Namely, there seem to be compelling scenarios in which there are multiple sources of incriminating statistical evidence. As we conjoin together different types of statistical evidence, it becomes increasingly incredible to suppose that a positive verdict would be impermissible. I suggest that none of the dominant views in the literature can easily accommodate such cases, and close by offering a diagnosis of my own.
An Interdisciplinary Approach to Investigate Preschool children’s Implicit Inferential Reasoning in Scientific Activities
Authors: Convertini Josephine
Published: August 2020

The implementation of Science, Technology, Engineering, and Mathematics (STEM) at school is one of the challenges of education in the twenty-first century, especially concerning the development of critical thinking during argumentative interactions. In this paper, I refer to an interdisciplinary approach with the aim to analyze the implicit inferential reasoning emerging in argumentative discussions among children during scientific activities. The study involved 25 preschool children at a kindergarten engaged in three problem solving tasks. The first activity was to build a tunnel, the second to build a bridge—both with the use of Lego©—and the third to build an hourglass with recycled materials. The tasks were video-recorded and the discussions transcribed. The analysis implied different steps: first, I identified the argumentative structure of each exchange according to the pragma-dialectical approach; then, I found the implicit premises using the Argumentum Model of Topics; afterward, I analyzed the argumentative discussions according to a sociocultural approach. The findings show a predominance of arguments based on causal relationships and indicate how children reason regarding complex aspects of a problem, such as the negative consequences of an action, the adequacy of the available tools, and the (possible) future conditions connected to the scientific activity they are involved in. The study opens a possibility to shift from how to implement STEM activities to what children already do when engaged in scientific tasks. It also encourages the adoption of an interdisciplinary approach to investigating the complex process of argumentation in preschool children.
Metabolome of canine and human saliva: a non-targeted metabolomics study
Authors: Turunen Soile , Puurunen Jenni , Auriola Seppo , Kullaa Arja M. , Kärkkäinen Olli , Lohi Hannes , Hanhineva Kati
Published: August 2020

Introduction

Saliva metabolites are suggested to reflect the health status of an individual in humans. The same could be true with the dog (Canis lupus familiaris), an important animal model of human disease, but its saliva metabolome is unknown. As a non-invasive sample, canine saliva could offer a new alternative material for research to reveal molecular mechanisms of different (patho)physiological stages, and for veterinary medicine to monitor dogs’ health trajectories.

Objectives

To investigate and characterize the metabolite composition of dog and human saliva in a non-targeted manner.

Methods

Stimulated saliva was collected from 13 privately-owned dogs and from 14 human individuals. We used a non-targeted ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-qTOF-MS) method to measure metabolite profiles from saliva samples.

Results

We identified and classified a total of 211 endogenous and exogenous salivary metabolites. The compounds included amino acids, amino acid derivatives, biogenic amines, nucleic acid subunits, lipids, organic acids, small peptides as well as other metabolites, like metabolic waste molecules and other chemicals. Our results reveal a distinct metabolite profile of dog and human saliva as 25 lipid compounds were identified only in canine saliva and eight dipeptides only in human saliva. In addition, we observed large variation in ion abundance within and between the identified saliva metabolites in dog and human.

Conclusion

The results suggest that non-targeted metabolomics approach utilizing UHPLC-qTOF-MS can detect a wide range of small compounds in dog and human saliva with partially overlapping metabolite composition. The identified metabolites indicate that canine saliva is potentially a versatile material for the discovery of biomarkers for dog welfare. However, this profile is not complete, and dog saliva needs to be investigated in the future with other analytical platforms to characterize the whole canine saliva metabolome. Furthermore, the detailed comparison of human and dog saliva composition needs to be conducted with harmonized study design.
Epidemiology of Headache in Children and Adolescents—Another Type of Pandemia
Authors: Nieswand Vera , Richter Matthias , Gossrau Gudrun
Published: August 2020

Purpose of Review

Headaches are not only responsible for restrictions in everyday life in adults. In children and adolescents, regular headaches lead also to reduced life quality and limitations in the social sphere, in school education, and in professional careers. Here, we provide an overview on the frequency of headache in children and adolescents with the aim of increasing awareness about this particular health issue.

Recent Findings

Overall, headache prevalence in children and adolescents has been increasing in recent years. From various regions worldwide, data describing headache, its forms, and consequences are growing. In addition, factors frequently correlated with headache are repeatedly investigated and named: besides genetic factors, psychosocial and behavioral factors are linked to the prevalence of headache.

Increasing evidence indicates that headache is underestimated as a common disorder in children and adolescents. Accordingly, too little emphasis is placed by society on its prevention and treatment. Thus, the extent of the social and health economic burden of frequent headaches in children and adolescents needs to be better illustrated, worldwide. Furthermore, the data collected in this review should support the efforts to improve outpatient therapy paths for young headache patients. Factors correlating with headache in pupils can draw our attention to unmet needs of these patients and allow physicians to derive important therapy contents from this data.
The possibility of identifying brain hemorrhage in putrefied bodies with PMCT
Authors: Tappero Carlo , Thali Michael J. , Schweitzer Wolf
Published: August 2020

This paper aims to demonstrate that post-mortem CT (PMCT) can locate intracranial hemorrhages, even in decomposed cases. This is of relevance in that post-mortem decomposition is particularly damaging to the brain tissue’s consistency, resulting in great difficulties to reliably diagnose and locate intracranial hemorrhages. We searched our case database of the last 11 years to find cases with decomposition of the body, where PMCT and an autopsy had been performed. We identified eleven cases according to these criteria. Postmortem interval ranged from 2 days to 2 weeks, and post-mortem radiological alteration index (RAI) was at or above 49. Eight out of eleven cases showed an intraparenchymal hemorrhage whereas the hemorrhage was extra-axial in the remaining three cases. Autopsy validated the presence of intracranial hemorrhage in all eleven cases, but location could not be confirmed due to liquid state of the brain. PMCT identified and localized intracranial hemorrhages in decomposed bodies, and in all of these cases, autopsy validated their presence. The actual cause of the hemorrhage (e.g. tumor, metastasis, vascular malformation, hypertensive hemorrhage) remained obscure. From this case series, it can be concluded that PMCT may add relevant information pertaining to localization of intracranial hemorrhages in decomposed bodies.
Decreased Mitochondrial Function, Biogenesis, and Degradation in Peripheral Blood Mononuclear Cells from Amyotrophic Lateral Sclerosis Patients as a Potential Tool for Biomarker Research
Authors: Araujo Beatriz Grisolia , Souza e Silva Luiz Felipe , de Barros Torresi Jorge Luiz , Siena Amanda , Valerio Berenice Cataldo Oliveira , Brito Mariana Dutra , Rosenstock Tatiana Rosado
Published: August 2020

Amyotrophic lateral sclerosis (ALS) is a multifactorial and progressive neurodegenerative disease of unknown etiology. Due to ALS’s unpredictable onset and progression rate, the search for biomarkers that allow the detection and tracking of its development and therapeutic efficacy would be of significant medical value. Considering that alterations of energy supply are one of ALS’s main hallmarks and that a correlation has been established between gene expression in human brain tissue and peripheral blood mononuclear cells (PBMCs), the present work investigates whether changes in mitochondrial function could be used to monitor ALS. To achieve this goal, PBMCs from ALS patients and control subjects were used; blood sampling is a quite non-invasive method and is cost-effective. Different parameters were evaluated, namely cytosolic calcium levels, mitochondrial membrane potential, oxidative stress, and metabolic compounds levels, as well as mitochondrial dynamics and degradation. Altogether, we observed lower mitochondrial calcium uptake/retention, mitochondria depolarization, and redox homeostasis deregulation, in addition to a decrease in critical metabolic genes, a diminishment in mitochondrial biogenesis, and an augmentation in mitochondrial fission and autophagy-related gene expression. All of these changes can contribute to the decreased ATP and pyruvate levels observed in ALS PBMCs. Our data indicate that PBMCs from ALS patients show a significant mitochondrial dysfunction, resembling several findings from ALS’ neural cells/models, which could be exploited as a powerful tool in ALS research. Our findings can also guide future studies on new pharmacological interventions for ALS since assessments of brain samples are challenging and represent a relevant limited strategy.
Family Formation: an Intergenerational Comparison Subtitlte: The Relevance of Social Inequalities for Family Formation in a Transnational Migration Context
Authors: Ammann Dula Eveline
Published: August 2020

How do processes of family formation change over generations? What is the relevance of social inequalities for these processes and what kinds of strategies do family members develop to deal with them? Based on a case study of members of two generations from the same family using a biographical approach, we will demonstrate the diversity of family formation within one family. The article generates insights about the complexity of family formation processes, as previous research has shown that there is a fertility variation between and within migrant groups of different origins. The selected family is involved in a transnational migration process, originally from the former Yugoslavia, coming to Switzerland and then moving to Kosovo. Migration experiences started with the grandfathers’ seasonal work migration. The family members were affected by social inequalities based on class, gender and ethnicity that are analysed using the concept of socio-cultural boundaries. The results illustrate the ways restrictions on access to the labour market, discrimination, educational institutions and selective migration regimes influence and shape family formation processes. It reveals that members of the same family develop diverse strategies to deal with exclusion and discrimination processes comparing their positions in transnational fields. We show how these family negotiation processes are interrelated with ethnicity and class and change over the generations. Furthermore, the analysis reveals that the transmission of gender norms in this family is influenced by the experienced socio-cultural boundaries. In sum, we show the complexity of family formation processes and intergenerational changes in interaction with intersectional social inequalities that are also shaped by migration policies.
StanceVis Prime: visual analysis of sentiment and stance in social media texts
Authors: Kucher Kostiantyn , Martins Rafael M. , Paradis Carita , Kerren Andreas
Published: August 2020

Text visualization and visual text analytics methods have been successfully applied for various tasks related to the analysis of individual text documents and large document collections such as summarization of main topics or identification of events in discourse. Visualization of sentiments and emotions detected in textual data has also become an important topic of interest, especially with regard to the data originating from social media. Despite the growing interest in this topic, the research problem related to detecting and visualizing various stances, such as rudeness or uncertainty, has not been adequately addressed by the existing approaches. The challenges associated with this problem include the development of the underlying computational methods and visualization of the corresponding multi-label stance classification results. In this paper, we describe our work on a visual analytics platform, called StanceVis Prime, which has been designed for the analysis of sentiment and stance in temporal text data from various social media data sources. The use case scenarios intended for StanceVis Prime include social media monitoring and research in sociolinguistics. The design was motivated by the requirements of collaborating domain experts in linguistics as part of a larger research project on stance analysis. Our approach involves consuming documents from several text stream sources and applying sentiment and stance classification, resulting in multiple data series associated with source texts. StanceVis Prime provides the end users with an overview of similarities between the data series based on dynamic time warping analysis, as well as detailed visualizations of data series values. Users can also retrieve and conduct both distant and close reading of the documents corresponding to the data series. We demonstrate our approach with case studies involving political targets of interest and several social media data sources and report preliminary user feedback received from a domain expert.

Graphic abstract
Recent Progress on Metal–Organic Framework and Its Derivatives as Novel Fire Retardants to Polymeric Materials
Authors: Zhang Jing , Li Zhi , Qi Xiao-Lin , Wang De-Yi
Published: August 2020

High flammability of polymers has become a major issue which has restricted its applications. Recently, highly crystalline materials and metal–organic frameworks (MOFs), which consisted of metal ions and organic linkers, have been intensively employed as novel fire retardants (FRs) for a variety of polymers (MOF/polymer). The MOFs possessed abundant transition metal species, fire-retardant elements and potential carbon source accompanied with the facile tuning of the structure and property, making MOF, its derivatives and MOF hybrids promising for fire retardancy research. The recent progress and strategies to prepare MOF-based FRs are emphasized and summarized. The fire retardancy mechanisms of MOF/polymer composites are explained, which may guide the future design for efficient MOF-based FRs. Finally, the challenges and prospects related to different MOF-based FRs are also discussed and aim to provide a fast and holistic overview, which is beneficial for researchers to quickly get up to speed with the latest development in this field.
Risk of posterior capsular rupture during phacoemulsification cataract surgery in eyes with previous intravitreal antivascular endothelial growth factor injections
Authors: Nagar Anindyt M. , Luis Joshua , Kainth Nimrath , Panos Georgios D. , Mckechnie Cordelia J. , Patra Sudeshna
Published: August 2020

Purpose:

To investigate whether previous intravitreal antivascular endothelial growth factor (VEGF) injections are a predictor for posterior capsular rupture (PCR) during phacoemulsification cataract surgery.

Setting:

Whipps Cross University Hospital Eye Treatment Centre, London, United Kingdom.

Design:

Single-center, retrospective, electronic medical record (EMR) database study with univariate analysis.

Methods:

Data were extracted from an EMR system on eyes undergoing phacoemulsification surgery between August 1, 2016, and January 1, 2018. Patient demographics, indication for intravitreal therapy, treatment type, the number of previous intravitreal injections (IVIs), diabetic status, surgeon grade, and operative complications were included as variables for analysis.

Results:

Data were available for 4047 cataract operations. Of these, 108 (2.7%) had undergone previous anti-VEGF IVI treatment. Three eyes were noted to have preoperative PC trauma and were excluded from the final analysis. The logistic regression analysis after exclusion of the eyes with pre-existing damage to the PC confirmed that previous anti-VEGF IVI treatment was associated with an increased risk of PCR when compared with the non-IVI group (6.67% vs 1.88%, P < .0001). There is a dose-dependent relationship between the number of anti-VEGF injections and the likelihood of PCR.

Conclusions:

Previous intravitreal anti-VEGF injections are significantly correlated with an increased risk of surgical PCR, despite the absence of visible structural damage to the posterior capsule preoperatively.
The translational sciences clinic: From bench to bedside
Authors: Halushka Perry , Loucks Tammy L. , Paranal Rechelle , Harvey Jillian , Briggman Kristen , Lee-Chavarria Diana , Feghali-Bostwick Carol
Published: August 2020

The mission of the National Center for Advancing Translational Science (NCATS) is to speed the development of drugs from discovery to approval to dissemination and implementation. The Medical University of South Carolina and the South Carolina Clinical and Translational Research Institute host a NCATS funded predoctoral T32 training grant (TL1) with a focus on translational research. Doctoral (PhD) trainees working at the bench usually have limited opportunity for clinical interactions to gain a clinical perspective on the diseases that are the focus of their dissertation research. To provide TL1 trainees with an opportunity to see how their research could be translated into improved patient care, we developed a mentored clinical exposure experience named the Translational Sciences Clinic. Trainees spend one-half day a week in a clinic related to their basic science research for one semester interacting with patients and clinical mentors and discuss the most recent literature related to the patient’s clinical problem with their clinical mentor. Trainees deemed the rotation to be one of the most rewarding experiences that they had as a part of their predoctoral training. Participating clinical mentors were also very enthusiastic and agreed that they would be willing to mentor similar trainees again.
From lifespan to healthspan: the role of nutrition in healthy ageing
Authors: Wickramasinghe Kremlin , Mathers John C. , Wopereis Suzan , Marsman Daniel S. , Griffiths James C.
Published: August 2020

Across the globe, there has been a marked increase in longevity, but significant inequalities remain. These are exacerbated by inadequate access to proper nutrition and health care services and to reliable information to make the decisions related to nutrition and health care. Many in economically developing as well as developed societies are plagued with the double-burden of energy excess and undernutrition. This has resulted in mental and physical deterioration, increased non-communicable disease rates, lost productivity, increased medical costs and reduced quality of life. While adequate nutrition is fundamental to good health at all stages of the life course, the impact of diet on prolonging good quality of life during ageing remains unclear. For progress to continue, there is need for new and/or innovative approaches to promoting health as individuals age, as well as qualitative and quantitative biomarkers and other accepted tools that can measure improvements in physiological integrity throughout life. A framework for progress has been proposed by the World Health Organization in their Global Strategy and Action Plan on Ageing and Health. Here, we focused on the impact of nutrition within this framework, which takes a broad, person-centred emphasis on healthy ageing, stressing the need to better understand each individual's intrinsic capacity, their functional abilities at various life stages, and the impact of their mental, and physical health, as well as the environments they inhabit.
Nationalism and Sport: A Review of the Field
Authors: Arnold Richard
Published: August 2020

The connection between nationalism and sport seems at once both obvious and manifest, with the most lavish praise of the nation often arising at sporting events. While a sizeable body of academic literature exists on the connection between the two concepts, it remains overlapping and unstructured. This state of the field review essay accounts for the major works in this field and categorizes it according to the function it fulfills in the subfield. Specifically, it focuses on sport as a mechanism for the diffusion and creation of nationalism, sport under conditions of globalization at Sporting Mega Events (SMEs), and the connection between sport and the distinction between civic and ethnic definitions of nationality.
Relating pollen representation to an evolving Amazonian landscape between the last glacial maximum and Late Holocene
Authors: Smith Richard J. , Mayle Francis E. , Maezumi S. Yoshi , Power Mitchell J.
Published: August 2020

In contrast to temperate regions, relationships between basin characteristics (e.g., type/size) and fossil pollen archives have received little attention in Amazonia. Here, we compare fossil pollen records of a small palm swamp (Cuatro Vientos; CV) and a nearby large lake (Laguna Chaplin, LCH) in Bolivian Amazonia, demonstrating that palm swamps can yield Quaternary pollen archives recording the history of terrestrial vegetation beyond the basin margin, rather than merely a history of localized swamp vegetation dynamics. The pollen assemblages from these two contrasting basins display remarkable agreement throughout their late Quaternary history, indicating past drier climates supported savanna landscape during the last glacial maximum (LGM; 24,000–18,000 cal yr BP) and savanna/semideciduous forest mosaic during the middle Holocene (7000-4750 cal yr BP) at both regional (inferred from LCH) and local (inferred from CV) spatial scales. Additionally, the local-scale catchment of CV and the basin's proximity to the riverine forests of the Río Paraguá enables exploration of the extent of gallery/riverine forests during the LGM and middle Holocene. We show that, between 24,000–4000 cal yr BP, riverine/gallery rainforests were substantially reduced compared with present, challenging the hypothesis that gallery rainforests were important refugia for rainforest species during the drier LGM and middle Holocene.
Atapuerca Neanderthal landscape at Fuente Mudarra site in Burgos, Spain, during Marine Isotope Stages 5–3
Authors: Santamaría Marta , Navazo Marta , Benito-Calvo Alfonso , Alonso Rodrigo , López Gloria I. , Carbonell Eudald
Published: August 2020

Fuente Mudarra is on a gentle slope on the left bank of the Pico River, near Sierra de Atapuerca, Burgos, Spain. A 12−m2test pit was dug at this large open-air site between 2012 and 2017. Several upper Pleistocene archaeological levels were documented. Results from Fuente Mudarra confirm that Neanderthal groups, little represented at cave sites, occupied Sierra de Atapuerca from the end of the middle Pleistocene and during the upper Pleistocene. The site also provides insight into Neanderthal spatial organization in the Atapuerca area and whether they used the caves in an occasional, non-habitual way like the open-air sites.
Epistaxis as a marker for severe acute respiratory syndrome coronavirus-2 status – a prospective study
Authors: Hussain MH , Mair M , Rea P
Published: August 2020

Objective

To evaluate the prevalence of severe acute respiratory syndrome coronavirus-2 infection in patients presenting with epistaxis to a tertiary otolaryngology unit.

Methods

A prospective study was conducted of 40 consecutive patients presenting with epistaxis referred to our tertiary otolaryngology unit. A group of 40 age-matched controls were also included. All patients underwent real-time reverse transcriptase polymerase chain reaction testing for severe acute respiratory syndrome coronavirus-2. Symptoms of fever, cough and anosmia were noted in the study group.

Results

The mean age was 66.5 ± 22.4 years in the study group. There were 22 males (55 per cent) and 18 females (45 per cent). The mean age in the control group was 66.3 ± 22.4 years (p = 0.935). There were six positive cases for severe acute respiratory syndrome coronavirus-2 (15 per cent) in the epistaxis group and one case (2.5 per cent) in the control group. The difference was statistically significant (p = 0.05).

Conclusion

Epistaxis may represent a presenting symptom of severe acute respiratory syndrome coronavirus-2 infection. This may serve as a useful additional criterion for screening patients.
Runaway dynamics in the DT phase of ITER operations in the presence of massive material injection
Authors: Vallhagen O. , Embreus O. , Pusztai I. , Hesslow L. , Fülöp T.
Published: August 2020

A runaway avalanche can result in a conversion of the initial plasma current into a relativistic electron beam in high-current tokamak disruptions. We investigate the effect of massive material injection of deuterium–noble gas mixtures on the coupled dynamics of runaway generation, resistive diffusion of the electric field and temperature evolution during disruptions in the deuterium–tritium phase of ITER operations. We explore the dynamics over a wide range of injected concentrations and find substantial runaway currents, unless the current quench time is intolerably long. The reason is that the cooling associated with the injected material leads to high induced electric fields that, in combination with a significant recombination of hydrogen isotopes, leads to a large avalanche generation. Balancing Ohmic heating and radiation losses provides qualitative insights into the dynamics; however, an accurate modelling of the temperature evolution based on energy balance appears crucial for quantitative predictions.
Differences in the cnidomes and toxicities of the oral arms of two commercially harvested rhizostome jellyfish species in Thailand
Authors: Kondo Yusuke , Suzuki Yasuko , Ohtsuka Susumu , Nagai Hiroshi , Tanaka Hayato , Srinui Khwanruan , Miyake Hiroshi , Nishikawa Jun
Published: August 2020

In Thailand, two species of rhizostome jellyfish, Rhopilema hispidum and Lobonemoides robustus, are commercially harvested. The cnidomes, nematocyst size and toxicities were compared between these species. Rhopilema hispidum and L. robustus each had four types of nematocysts on their oral arms. For R. hispidum, these nematocyst types included two types of isorhiza and two types of rhopaloid, while in L. robustus, there were three types of isorhiza and one type of rhopaloid. For R. hispidum, tubule lengths of the largest nematocyst type (large round isorhiza; mean ± SD = 313.8 ± 62.2 μm) were significantly longer than those of L. robustus (large ellipsoid rhopaloid; 162.1 ± 38.5 μm). Using the freshwater shrimp, Palaemon paucidens, in a bioassay, we determined that the lethal nematocyst concentrations for R. hispidum and L. robustus were 5705.3 ± 1118.1 and 3408.3 ± 1032.9 unit g−1 wet weight, respectively, and that these concentrations were significantly higher in the former than in the latter.