bluuebunny/crossref_metadata_2025 huggingface dataset:
The Spatial Equilibrium Model of Elderly Care Facilities with High Spatiotemporal Sensitivity and Its Economic Associations Study
Authors: Li Hongyan , Li Rui , Cai Jing , Wang Shunli
Published: July 2024

The global population aging poses new challenges in allocating care facilities for the elderly. This demographic trend also influences economic development and the quality of urban life. However, current research focuses on the supply of elderly care facilities and primarily uses administrative divisions as a scale, resulting in low spatiotemporal sensitivity in evaluating the spatial equilibrium of elderly care facilities (SEECF). The relationship between the SEECF and economic development is not clear. In response to these problems, we proposed a spatial equilibrium model of elderly care facilities with high spatiotemporal sensitivity (SEM-HSTS) and explored the spatiotemporal associations between the SEECF and economic development. Considering the spatial accessibility rate of elderly care services (SARecs) and the spatiotemporal supply–demand ratio for elderly care services (STSDRecs), two types of supply–demand relationship factors were constructed. Then, a spatiotemporal accessibility of medical services (STAms) factor was obtained based on a modified two-step floating catchment area (M2SFCA) method. On this basis, the SEM-HSTS was constructed based on the theory of coordinated development. Further, a panel threshold model was employed to evaluate the influence relationships among population aging, SEECF, and gross domestic product (GDP) in different phases. Finally, spatial autocorrelation and Geodetector explored the spatial associations between SEECF and GDP across complex urban land use categories (ULUC). The experimental results at a 100-m grid scale showed that the SEM-HSTS exhibited higher spatiotemporal heterogeneity than the classical accessibility method, with elevated spatiotemporal sensitivity. Effectively identified various spatial imbalances, such as undersupply and resource waste. The panel model captured phased relationship changes, showing that SEECF had inhibitory and promotional effects on GDP in pre- and post-aging societies, with stronger effects as balance approached. Moreover, the combined interaction of ULUC and GDP had a more significant influence on SEECF than any individual factor, with GDP exerting a more significant influence. This study provides an empirical basis for creating resource-efficient elderly care facility systems and optimizing layouts.
A Comprehensive Bibliometric Analysis of Business Process Management and Knowledge Management Integration: Bridging the Scholarly Gap
Authors: Berniak-Woźny Justyna , Szelągowski Marek
Published: July 2024

In the ever-evolving landscape of organisational optimisation, the integration of business process management (BPM) and knowledge management (KM) emerges as a critical challenge. Beyond the opportunity to expedite the improvement of the organisation’s operations, this integration serves as a gateway to unlocking the full potential of organisational knowledge and digital transformation. With its comprehensive evaluation of the dimensions of research on BPM and KM, this article aims to unveil predominant topics and evolving trends within this intersection. By doing so, it seeks to catalyse meaningful advancements in organisational management practices, underscoring the relevance and importance of this topic to the audience. The authors conducted a rigorous research process. Using bibliographic analysis, they selected 359 publications from the Scopus database. They employed performance analysis and scientific mapping methods to extract meaningful insights facilitated by MS Excel and VOSviewer applications. Additionally, they conducted an in-depth analysis of 37 publications chosen through bibliographic coupling analysis. The findings highlight a significant gap in the scholarly discourse on BPM and KM, which is evident in the limited research outcomes and minimal influence on decision-making processes. This study reiterates the need for increased dedication to this research realm, particularly in areas identified in the future research agenda recommendations, to stimulate significant advancements in organisational management practices. This paper stands out from the up-to-date reviews by offering a unique contribution to the BPM and KM integration field. While these reviews often focus on specific niches within the broader domain, this study takes a holistic approach. It provides a comprehensive overview of the existing literature on integrating BPM and KM, delving into the quantity and quality of existing research. It also identifies emerging themes and potential directions for future scholarship, ensuring a robust understanding of the integrative landscape of BPM and KM.
AquaVision: AI-Powered Marine Species Identification
Authors: Mifsud Scicluna Benjamin , Gauci Adam , Deidun Alan
Published: July 2024

This study addresses the challenge of accurately identifying fish species by using machine learning and image classification techniques. The primary aim is to develop an innovative algorithm that can dynamically identify the most common (within Maltese coastal waters) invasive Mediterranean fish species based on available images. In particular, these include Fistularia commersonii, Lobotes surinamensis, Pomadasys incisus, Siganus luridus, and Stephanolepis diaspros, which have been adopted as this study’s target species. Through the use of machine-learning models and transfer learning, the proposed solution seeks to enable precise, on-the-spot species recognition. The methodology involved collecting and organising images as well as training the models with consistent datasets to ensure comparable results. After trying a number of models, ResNet18 was found to be the most accurate and reliable, with YOLO v8 following closely behind. While the performance of YOLO was reasonably good, it exhibited less consistency in its results. These results underline the potential of the developed algorithm to significantly aid marine biology research, including citizen science initiatives, and promote environmental management efforts through accurate fish species identification.
Digital Sentinels and Antagonists: The Dual Nature of Chatbots in Cybersecurity
Authors: Szmurlo Hannah , Akhtar Zahid
Published: July 2024

Advancements in artificial intelligence, machine learning, and natural language processing have culminated in sophisticated technologies such as transformer models, generative AI models, and chatbots. Chatbots are sophisticated software applications created to simulate conversation with human users. Chatbots have surged in popularity owing to their versatility and user-friendly nature, which have made them indispensable across a wide range of tasks. This article explores the dual nature of chatbots in the realm of cybersecurity and highlights their roles as both defensive tools and offensive tools. On the one hand, chatbots enhance organizational cyber defenses by providing real-time threat responses and fortifying existing security measures. On the other hand, adversaries exploit chatbots to perform advanced cyberattacks, since chatbots have lowered the technical barrier to generate phishing, malware, and other cyberthreats. Despite the implementation of censorship systems, malicious actors find ways to bypass these safeguards. Thus, this paper first provides an overview of the historical development of chatbots and large language models (LLMs), including their functionality, applications, and societal effects. Next, we explore the dualistic applications of chatbots in cybersecurity by surveying the most representative works on both attacks involving chatbots and chatbots’ defensive uses. We also present experimental analyses to illustrate and evaluate different offensive applications of chatbots. Finally, open issues and challenges regarding the duality of chatbots are highlighted and potential future research directions are discussed to promote responsible usage and enhance both offensive and defensive cybersecurity strategies.
Designing of High-Performance MnNiS@MXene Hybrid Electrode for Energy Storage and Photoelectrochemical Applications
Authors: Ahmad Maqsood , Imran Muhammad , Afzal Amir Muhammad , Ahsan ul Haq Muhammad , Alqarni Areej S. , Iqbal Muhammad Waqas , Issa Shams A. M. , Zakaly Hesham M. H.
Published: July 2024

The overconsumption of fossil fuels is leading to worsening environmental damage, making the generation of clean, renewable energy an absolute necessity. Two common components of electrochemical energy storage (EES) devices are batteries and supercapacitors (SCs), which are among the most promising answers to the worldwide energy issue. In this study, we introduce an exceptionally efficient electrode material for supercapacitors, composed of a hydrothermally synthesized composite known as MnNiS@MXene. We utilized XRD, SEM, and BET to analyze the material’s crystallinity, morphology, and surface area. The Qs of MnNiS@MXene was a remarkable 1189.98 C/g or 1983.3 F/g at 2 A/g under three electrode assemblies in 1 M KOH electrolyte solution. Activated carbon was used as the negative electrode, while MnNiS@MXene served as the positive electrode in the assembled supercapattery device (MnNiS@MXene//AC). This device showed exceptional performance, a specific capacity of 307.18 C/g, a power density of 1142.61 W/kg, and an energy density of 34.79 Wh/kg. Additionally, cyclic durability was evaluated through 7000 cycles of charging/discharging, demonstrating that it maintained approximately 87.57% of its original capacity. The successful integration of these materials can lead to electrodes with superior energy storage capabilities and efficient photoelectrochemical performance. The aforementioned findings suggest that MnNiS@MXene exhibits promising potential as an electrode material for forthcoming energy storage systems.
Safety of the Entomopathogenic Fungus Beauveria bassiana for Wild and Laboratory-Reared Chrysoperla lucasina Strains
Authors: Morda Walaa , Nuvoli Maria Tiziana , Ruiu Luca
Published: July 2024

The need to reduce the impact of plant protection products on agroecosystems fosters the use of augmentative biological control involving the release of beneficial species into the field, the employment of entomopathogenic microbials, and the protection of naturally occurring biocontrol agents. This study aimed to investigate the compatibility of the entomopathogenic fungus Beauveria bassiana with the generalist insect predator Chrysoperla lucasina, in comparative experiments involving a laboratory-reared and a wild chrysopid strain. The larvae of the predators were exposed to different concentrations of fungal conidia up to a concentration of 107 conidia/mL by contact and ingestion. The treated insects showed only slight differences in terms of survival and immature development time compared to the untreated control insects. A significant decrease in the proportion of the male adults of C. lucasina that emerged from the laboratory-reared larvae that were exposed to higher concentrations of the fungus suggested a potentially different susceptibility between the sexes. A slightly lower adult emergence rate was observed in the wild strain, while no significant differences were recorded in the adult reproductive performance. These findings indicate that the B. bassiana strain ATCC 74040, at concentrations commonly used in the field, did not pose a significant risk to C. lucasina and can be safely used in combination with this predator for sustainable pest management.
Evaluation of an Attract-and-Kill Strategy Using Long-Lasting Insecticide Nets for the Management of the Brown Marmorated Stink Bug in Northern Italy
Authors: Masetti Antonio , Morelli Agata , Fagioli Luca , Pradolesi Gianfranco , Nicoli Riccardo , Scagliarini Olmo , Tommasini Maria Grazia , Preti Michele
Published: July 2024

The brown marmorated stink bug (BMSB), Halyomorpha halys (Stål) (Hemiptera: Pentatomidae), is causing extensive economic losses in tree fruit crops. Including attract-and-kill (AK) strategies targeting BMSBs in an integrated pest management framework could reduce the amounts of insecticides sprayed and benefit growers, consumers and the environment. This study evaluated the effectiveness of an area-wide AK strategy across an intensive fruticulture region of Northern Italy, comparing four paired pear sites with and without two AK stations ha−1. These stations consisted of long-lasting insecticide-treated nets containing alpha-cypermethrin, baited with the BMSB aggregation pheromone and synergist. BMSB abundance was estimated using black-standing monitoring traps, and fruit damage upon harvest was recorded across all sites. The AK stations did not decrease the BMSB abundance nor the fruit damage, while after harvest significantly lower BMSB captures were detected in the AK sites compared to the control sites. Whilst the lures’ efficacy was corroborated by this research, the killing method requires improvement and refinement.
Compromised Cerebral Arterial Perfusion, Altered Brain Tissue Integrity, and Cognitive Impairment in Adolescents with Complex Congenital Heart Disease
Authors: Pike Nancy A. , Roy Bhaswati , Cabrera-Mino Cristina , Halnon Nancy J. , Lewis Alan B. , Shao Xingfeng , Wang Danny J. J. , Kumar Rajesh
Published: July 2024

(1) Introduction: Adolescents with complex congenital heart disease (CCHD) show brain tissue injuries in regions associated with cognitive deficits. Alteration in cerebral arterial perfusion (CAP), as measured by arterial transit time (ATT), may lead to perfusion deficits and potential injury. Our study aims to compare ATT values between CCHD patients and controls and assess the associations between ATT values, MD values, and cognitive scores in adolescents with CCHD. (2) Methods: 37 CCHD subjects, 14–18 years of age, who had undergone surgical palliation and 30 healthy controls completed cognitive testing and brain MRI assessments using a 3.0-Tesla scanner. ATT values and regional brain mean diffusivity [MD] were assessed for the whole brain using diffusion tensor imaging. (3) Results: The mean MoCA values [23.1 ± 4.1 vs. 28.1 ± 2.3; p < 0.001] and General Memory Index, with a subscore of WRAML2 [86.8 ± 15.4 vs. 110.3 ± 14.5; p < 0.001], showed significant cognitive deficits in CCHD patients compared to controls. The mean global ATT was significantly higher in CCHD patients versus controls (mean ± SD, s, 1.26 ± 0.11 vs. 1.19 ± 0.11, p = 0.03), respectively. The partial correlations between ATT values, MD values, and cognitive scores (p < 0.005) showed significant associations in areas including the hippocampus, prefrontal cortices, cerebellum, caudate, anterior and mid cingulate, insula, thalamus, and lingual gyrus. (4) Conclusions: Adolescents with CCHD had prolonged ATTs and showed correlation with clinical measurements of cognitive impairment and MRI measurements of brain tissue integrity. This suggests that altered CAP may play a role in brain tissue injury and cognitive impairment after surgical palliation.
Progression of Scoliosis after Skeletal Maturity in Patients with Cerebral Palsy: A Systematic Review
Authors: Victor Klaas , Moens Pierre
Published: July 2024

Background: The progression of scoliosis has been observed in skeletally mature patients with cerebral palsy (CP). The aims of this systematic review were to determine the incidence of curve progression of untreated scoliosis after skeletal maturity, to estimate the average annual increase and to identify factors that influence the progression. Methods: A systematic literature search was performed in PubMed, Embase and the Cochrane Library for original research articles published between 1968 and May 2024 with a retrospective, prospective or cross-sectional design, investigating CP patients that were followed up beyond the age of 15 years. The search was limited to articles in English, French, German and Dutch. Articles were excluded if the study population concerned neuromuscular diseases other than CP. After an assessment of the methodological quality of each study, estimates of annual curve progression and the effect of the investigated risk factors for progression were recorded systematically and synthetized. Results: Fifteen studies met the inclusion criteria, resulting in a total sample size of 2569 participants. The study populations of the included original research articles were small and heterogeneous in terms of patient age and the type and severity of CP. Curve progression after skeletal maturity occurred in all included studies. A greater curve magnitude at the end of adolescence and a severe motor deficit (an inability to walk or GMFCS IV-V) were identified as significant risk factors for the progression of scoliosis after skeletal maturity. If at least one of these risk factors was present, scoliotic curves progressed after skeletal maturity in up to 74% of patients, with an average annual increase of 1.4 to 3.5 degrees per year. No significant association was found between curve progression and the physiologic type of CP, the type of scoliotic curve, previous hip surgery, positioning and gravity, weight and length, sex, epilepsy, or pelvic obliquity. Findings on the effect of hip instability were inconsistent: a positive correlation was found with the progression of scoliosis overall, but not after skeletal maturity in particular. A significant selection bias should be considered in the calculation of average annual curve progression, as patients that received interventions to halt curve progression were excluded from follow-up. Conclusions: The identification of risk factors in patients with CP and scoliosis can aid in predicting curve progression and managing follow-ups in clinical practice. Based on the findings in this review a radiographic follow-up once every 3 years is recommended for skeletally mature CP patients with at least one risk factor, and once every 5 years if no risk factors are present.
Fibromyalgia and Skin Disorders: A Systematic Review
Authors: D’Onghia Martina , Ciaffi Jacopo , Calabrese Laura , Tognetti Linda , Cinotti Elisa , Rubegni Pietro , Frediani Bruno , Ursini Francesco
Published: July 2024

Background: Fibromyalgia is a complex multifaceted syndrome primarily characterised by chronic musculoskeletal pain, fatigue, and functional symptoms. Although FM is known to be associated with several comorbidities, the aim of this systematic review was to comprehensively examine the available evidence regarding the relationship between FM and dermatological manifestations. Methods: We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, and MedLine and Web of Science (WOS) databases were searched up to June 2023. After removing duplicate records, 21 articles were deemed eligible for inclusion in the qualitative synthesis. Results: Overall, the included studies revealed an increased frequency of FM among patients with cutaneous diseases, including psoriasis, chronic urticaria, contact allergy, acneiform disorders, hidradenitis suppurativa, and vitiligo. Additionally, the presence of comorbid FM may intensify skin conditions, which has a negative impact on quality of life and vice versa. Conclusions: Although the causal mechanisms of FM are still far from being understood, this systematic review suggests a relationship between FM and skin disorders. However, further research is encouraged in this area.
Association of Centre Quality Certification with Characteristics of Patients, Management, and Outcomes Following Carotid Endarterectomy or Carotid Artery Stenting
Authors: Saicic Stefan , Knappich Christoph , Kallmayer Michael , Kirchhoff Felix , Bohmann Bianca , Lohe Vanessa , Naher Shamsun , Böhm Julian , Lückerath Sofie , Eckstein Hans-Henning , Kuehnl Andreas
Published: July 2024

Background: The aim of this study was to analyze the association between center quality certifications and patients’ characteristics, clinical management, and outcomes after carotid revascularization. Methods: This study is a pre-planned sub-study of the ISAR-IQ project, which analyzes data from the Bavarian subset of the nationwide German statutory quality assurance carotid database. Hospitals were classified as to whether a certified vascular center (cVC) or a certified stroke unit (cSU) was present on-site or not. The primary outcome event was any stroke or death until discharge from the hospital. Results: In total, 31,793 cases were included between 2012 and 2018. The primary outcome rate in asymptomatic patients treated by CEA ranged from 0.7% to 1.5%, with the highest rate in hospitals with cVC but without cSU. The multivariable regression analysis revealed a significantly lower primary outcome rate in centers with cSU in asymptomatic patients (aOR 0.69; 95% CI 0.56–0.86; p < 0.001). In symptomatic patients needing emergency treatment, the on-site availability of a cSU was associated with a significantly lower primary outcome rate (aOR 0.56; 95% CI 0.40–0.80; p < 0.001), whereas the presence of a cVC was associated with higher risk (aOR 3.07; 95% CI 1.65–5.72). Conclusions: This study provides evidence of statistically significant better results in some sub-cohorts in certified centers. In centers with cSU, the risk of any stroke or death was significantly lower in asymptomatic patients receiving CEA or symptomatic patients treated by emergency CEA.
Combined Use of MITRACLIP and Ventricular ASSIST Devices in Cardiogenic Shock: MITRA-ASSIST Registry
Authors: Rivero-Santana Borja , Jurado-Roman Alfonso , Pascual Isaac , Li Chi Hion , Jimenez Pilar , Estevez-Loureiro Rodrigo , Cepas-Guillén Pedro , Benito-González Tomás , Serrador Ana , De La Torre-Hernandez Jose Maria , Avanzas Pablo , Fernandez-Peregrina Estefania , Nombela Luis , Caneiro-Queija Berenice , Freixas Xavier , Fernandez-Vazquez Felipe , Amat-Santos Ignacio , Lee Dae-Hyun , Leon Victor , Arzamendi Dabit , Moreno Raul , Galeote Guillermo
Published: July 2024

Background: Patients with cardiogenic shock (CS) and mitral regurgitation (MI) have a prohibitive risk that contraindicates surgical treatment. Although the feasibility of transcatheter edge-to-edge therapy (TEER) has been demonstrated in this setting, the benefit of the combined use of TEER with mechanical circulatory support devices (MCS) has not been studied. The aim of this study was to evaluate the clinical outcomes of TEER in patients with MCS. Methods: The MITRA-ASSIST study is a retrospective multicentre Spanish registry that included patients with MR and CS who underwent TEER in combination with MCS. The primary endpoint was death from any cause at 12 months. The secondary endpoint was a composite of death from any cause or hospitalisation for heart failure at 12 months. Results: A total of twenty-four patients in nine high-volume Spanish centres (66.2 (51–82) years, 70.8% female, EuroSCORE II 20.4 ± 17.8) were included. Acute ST-elevation myocardial infarction was the main CS aetiology (56%), and the most implanted MCS was the intra-aortic balloon pump (82.6%), followed by ECMO (8.7%), IMPELLACP® (4.3%), or a combination of both (4.3%). Procedural success was 95.8%, with 87.5% in-hospital survival. At 12-month follow-up, 25.0% of patients died, and 33.3% had a composite event of death from any cause or hospitalisation for heart failure. Conclusions: TEER in patients with concomitant CS and MR who require MCS appears to be a promising therapeutic alternative with a high device procedural success rate and acceptable mortality and heart failure readmission rates at follow-up.
KLHL14 and E-Cadherin Nuclear Co-Expression as Predicting Factor of Nonfunctioning PitNET Invasiveness: Preliminary Study
Authors: Berardinelli Jacopo , Russo Valentina , Canciello Angelo , Di Giacinto Oriana , Mauro Annunziata , Nardinocchi Delia , Bove Ilaria , Solari Domenico , Del Basso De Caro Marialaura , Cavallo Luigi Maria , Barboni Barbara
Published: July 2024

Background/Objectives. Novel diagnostic and therapeutic approaches are needed to improve the clinical management of nonfunctioning pituitary neuroendocrine tumors (NF-PitNETs). Here, the expression of two proteins controlling the epithelial–mesenchymal transition (EMT)—an underlying NF-PitNET pathogenic mechanism—were analyzed as prognostic markers: E-cadherin (E-Cad) and KLHL14. Methods. The immunohistochemistry characterization of KLHL14 and E-Cad subcellular expression in surgical specimens of 12 NF-PitNET patients, with low and high invasiveness grades (respectively, Ki67+ < and ≥3%) was carried out. Results. The analysis of healthy vs. NF-PitNET tissues demonstrated an increased protein expression and nuclear translocation of KLHL14. Moreover, both E-Cad and KLHL14 shifted from a cytoplasmic (C) form in a low invasive NF-PitNET to a nuclear (N) localization in a high invasive NF-PitNET. A significant correlation was found between E-Cad/KLHL14 co-localization in the cytoplasm (p = 0.01) and nucleus (p = 0.01) and with NF-PitNET invasiveness grade. Conclusions. Nuclear buildup of both E-Cad and KLHL14 detected in high invasive NF-PitNET patients highlights a novel intracellular mechanism governing the tumor propensity to local invasion (Ki67+ ≥ 3%). The prolonged progression-free survival trend documented in patients with lower KLHL14 expression further supported such a hypothesis even if a larger cohort of NF-PitNET patients have to be analyzed to definitively recognize a key prognostic role for KLHL14.
Selective, Temporary Postoperative Inhibition of Lymphangiogenesis by Integrin α5β1 Blockade Improves Allograft Survival in a Murine Model of High-Risk Corneal Transplantation
Authors: Dietrich-Ntoukas Tina , Bock Felix , Onderka Jasmine , Hos Deniz , Bachmann Bjoern O. , Zahn Grit , Cursiefen Claus
Published: July 2024

Background: Corneal inflammatory hem- and lymphangiogenesis significantly increase the risk for immune rejection after subsequent allogeneic corneal transplantation. The purpose of this study was to analyze the impact of temporary selective inhibition of lymphangiogenesis after transplantation on graft survival. Methods: Allogeneic transplantation from C57BL/6 mice to BalbC mice was performed as “high-risk” keratoplasty in a prevascularized corneal host bed (suture-induced inflammatory corneal neovascularization). The treatment group received integrin α5β1-blocking small molecules (JSM6427) at the time of transplantation and for two weeks afterwards. Control mice received a vehicle solution. Grafts were evaluated weekly for graft rejection using an opacity score. At the end of the follow-up, immunohistochemical staining of corneal wholemounts for lymphatic vessels as well as CD11b+ immune cells was performed. Results: Temporary postoperative inhibition of lymphangiogenesis by JSM6427 improved the corneal graft survival significantly. At the end of the follow-up, no significant reduction in CD11b+ immunoreactive cells within the graft compared to controls was found. Conclusions: The significant improvement of corneal graft survival by the selective, temporary postoperative inhibition of lymphangiogenesis after keratoplasty using integrin antagonists shows the impact of lymphatic vessels in the early postoperative phase. Retarding lymphatic vessel ingrowth into the graft might be sufficient for the shift to immunological tolerance in the postoperative period, even after high-risk keratoplasty.
Comparative Analysis of Ketorolac and Parecoxib for Postoperative Pain Management in Uvulopalatopharyngoplasty
Authors: Hsieh Cheng-Yu , Sun Chuan-Hung , Lin Chung-Ching , Chou Yi-Fan
Published: July 2024

Background/Objectives: Uvulopalatopharyngoplasty (UPPP) is a prevalent surgical procedure for treating obstructive sleep apnea. Effective postoperative pain management is crucial for patient comfort and recovery. This study aimed to compare the analgesic efficacies of parecoxib and ketorolac in patients undergoing UPPP. Methods: A prospective, randomized, double-blind study was conducted on 83 patients who received either parecoxib (40 mg intravenously every 12 h) or ketorolac (30 mg intravenously every 8 h) for 2 days following UPPP. Postoperative pain and swallowing discomfort were assessed using visual analog scales (VASs) at 4, 24, 48, and 72 h. The time to resume eating and adverse reactions were also recorded. Results: At 24 and 48 h postoperatively, the mean VAS score was significantly higher in the ketorolac group compared to the parecoxib group (5.0 ± 2.3 vs. 3.6 ± 2.2, p = 0.005 and 3.9 ± 2.2 vs. 2.5 ± 1.7, p < 0.001, respectively). However, no significant difference in the mean VAS scores was observed between the two groups at 72 h postoperatively. With regards to postoperative swallowing pain, the ketorolac group exhibited significantly higher mean VAS scores than the parecoxib group at 4, 24, 48, and 72 h postoperatively. Conclusions: Intravenous parecoxib may offer superior analgesic benefits in the early postoperative period, particularly in alleviating swallowing pain, compared to ketorolac in UPPP procedures.
Turning the Tide against Herpes Zoster in Rheumatoid Arthritis Patients Treated with JAK Inhibitors
Authors: Cito Andrea , Fornaro Marco , Carenza Angela , Anelli Maria Grazia , Scioscia Crescenzio , Iannone Florenzo , Lopalco Giuseppe
Published: July 2024

Objectives: This study aimed to evaluate the incidence of Herpes Zoster (HZ) in patients with rheumatoid arthritis (RA) treated with Janus kinase inhibitors (JAKi), and to predict potential risk factors for HZ development. Methods: We retrospectively analysed medical records from RA patients at our rheumatology unit who met the 2010 ACR/EULAR criteria for RA and were receiving JAKi. The incidence and course of HZ were assessed through chart review and supplementary phone interviews. Results: A total of 198 JAKi-treated patients were monitored for an average of 18.5 months. Nine subjects experienced HZ, resulting in an incidence of 2.95 per 100 patient-years. No demographic or treatment-related differences were found among patients who developed HZ and those who did not. Disease duration (OR: 1.06, 95% CI: 1.01–1.12), time on JAKi treatment (OR: 1.04, 95% CI: 1.009–1.073), higher disease activity at JAKi initiation (OR: 4.16, 95% CI: 1.07–16.17), and at 3-month follow-up (OR: 6.0, 95% CI: 1.35–26.60) were identified as predictors of HZ occurrence. Thirty-six patients received vaccination against HZ, and none reported adverse reactions or flare-ups during a mean follow-up of 9.6 months. Conclusions: The incidence of HZ aligns with published data, suggesting that disease and treatment duration, as well as disease activity, are significant predictors of HZ in RA patients on JAKi therapy. Vaccination against HZ proved to be safe and effective, underscoring its potential protective value in this patient population.
Ultrasound for Intra-Operative Detection of Peri-Centimetric Pulmonary Nodules in Uniportal Video-Assisted Thoracic Surgery (VATS): A Comparison with Conventional Techniques in Multiportal VATS
Authors: Bastone Sebastiano Angelo , Patirelis Alexandro , Luppichini Matilde , Ambrogi Vincenzo
Published: July 2024

Background: Video-assisted thoracic surgery (VATS) has become the gold-standard approach for lung resections. Given the impossibility of digital palpation, we witnessed the progressive development of peri-centimetric and deeply located pulmonary nodule alternative detection techniques. Intra-operative lung ultrasound is an increasingly effective diagnostic method, although only a few small studies have evaluated its accuracy. This study analyzed the effectiveness and sensitivity of uniportal VATS with intra-operative lung ultrasound (ILU), in comparison to multiportal VATS, for visualizing solitary and deep-sited pulmonary nodules. Methods: Patient data from October 2021 to October 2023, from a single center, were retrospectively gathered and analyzed. In total, 31 patients who received ILU-aided uniportal VATS (Group A) were matched for localization time, operative time, sensitivity, and post-operative complications, with 33 undergoing nodule detection with conventional techniques, such as manual or instrumental palpation, in multiportal VATS (Group B). Surgeries were carried out by the same team and ILU was performed by a certified operator. Results: Group A presented a significantly shorter time for nodule detection [median (IQR): 9 (8–10) vs. 14 (12.5–15) min; p < 0.001] and operative time [median (IQR): 33 (29–38) vs. 43 (39–47) min; p < 0.001]. All nodules were correctly localized and resected in Group A (sensitivity 100%), while three were missed in Group B (sensitivity 90.9%). Two patients in Group B presented with a prolonged air leak that was conservatively managed, compared to none in Group A, resulting in a post-operative morbidity rate of 6.1% vs. 0% (p = 0.16). Conclusions: ILU-aided uniportal VATS was faster and more effective than conventional techniques in multiportal VATS for nodule detection.
False Boss Connection for Precision Machining of Composites with Soft and Brittle Characteristics
Authors: Yuan Xinman , Li Bo , Feng Feng , Xu Jie , Song Ge , Liang Yiying , Ma Yuan , Xu Chao , Wang Fuji , Feng Pingfa
Published: July 2024

Composite materials are widely used in the new generation of aviation equipment due to their comprehensive performance. However, the part fixture is usually difficult during the machining of composites with soft and brittle characteristics, such as the Nomex honeycomb. Therefore, the holding method based on the false boss connection can be utilized due to its advantages of low cost, less pollution, and a short preparation period. In this study, the method to determine and optimize the critical parameters of the false boss design is proposed to address the issue that they previously relied heavily on the experience of engineers, which often results in much waste of materials. To determine the critical parameters, a simulation model is constructed for Nomex honeycomb core parts machining with a false boss holding. Based on the simulation model, the stability of the machining process is analyzed, and the weak link of the false boss between different milling areas is studied. Furthermore, the difference in the shape of different parts is considered, and the reasonable critical parameters of the false boss are obtained through analysis.
Cuttlefish Bone-Derived Calcium Phosphate Bioceramics Have Enhanced Osteogenic Properties
Authors: Pang Boqi , Xian Jiaru , Chen Jiajun , Ng Liqi , Li Mengting , Zhao Guangchun , E Yixun , Wang Xiaorui , Cao Xiaxin , Zhang Changze , Zhang Mingjing , Liu Chaozong
Published: July 2024

Cuttlefish bones are byproducts of cuttlefish processing and are readily available in the marine food industry. In this study, calcium phosphate bioceramics were prepared from cuttlefish bones using a two-stage hydrothermal calcination process. The results indicated that all bioceramics derived from cuttlefish bones had a higher degradation capacity, better bone-like apatite formation ability, and higher degree of osteogenic differentiation than commercially available hydroxyapatite. Notably, β-tricalcium phosphate, which had the highest degree of Ca2+ and Sr2+ dissolution among the bioceramics extracted, can significantly upregulate osteogenic markers (alkaline phosphatase, osteocalcin) and stimulate bone matrix mineralization. Thus, it is a promising bioceramic material for applications in bone regeneration.
Assessment of Hull and Propeller Performance Degradation Based on TSO-GA-LSTM
Authors: Huang Guolei , Liu Yifan , Xin Jianjian , Bao Tiantian
Published: July 2024

Evaluating the degradation of hull and ship performance and exploring their degradation pathways is crucial for developing scientific and reasonable ship maintenance plans. This paper proposes a two-stage optimization (TSO) algorithm that combines the Genetic Algorithm (GA) and Long Short-Term Memory (LSTM) network, capable of simultaneously optimizing input features and model parameters to enhance the accuracy and generalization ability of speed prediction models. Additionally, a performance degradation assessment method based on speed loss is provided, aimed at evaluating the degradation of hull and propeller performance, as well as extracting the performance degradation paths. The results indicated that the proposed TSO-LSTM-GA algorithm significantly outperformed existing baseline models. Furthermore, the provided performance degradation assessment method demonstrated certain effectiveness on the target ship data, with a measured degradation rate of 0.00344 kn/d and a performance degradation of 9.569% over 478 days, corresponding to an annual speed loss of 1.257 kn.
Hybrid Path Planning Strategy Based on Improved Particle Swarm Optimisation Algorithm Combined with DWA for Unmanned Surface Vehicles
Authors: Li Jing , Wan Lili , Huang Zhen , Chen Yan , Tang Huiying
Published: July 2024

Path planning is one of the core issues in the autonomous navigation of an Unmanned Surface Vehicle (USV), as the accuracy of the results directly affects the safety of the USV. Hence, this paper proposes a USV path planning algorithm that integrates an improved Particle Swarm Optimisation (PSO) algorithm with a Dynamic Window Approach (DWA). Firstly, in order to advance the solution accuracy and convergence speed of the PSO algorithm, a nonlinear decreasing inertia weight and adaptive learning factors are introduced. Secondly, in order to solve the problem of long path and path non-smoothness, the fitness function of PSO is modified to consider both path length and path smoothness. Finally, the International Regulations for Preventing Collisions at Sea (COLREGS) are utilised to achieve dynamic obstacle avoidance while complying with maritime practices. Numerical cases verify that the path planned via the proposed algorithm is shorter and smoother, guaranteeing the safety of USV navigation while complying with the COLREGS.
Direct Adaptive Multi-Resampling Turbo Equalizer for Underwater Acoustic Single-Carrier Communication
Authors: Lin Zehua , Wang Lei , Peng Cong , Zhang Shuhao
Published: July 2024

A wideband Doppler Effect is a significant challenge for underwater acoustic communications (UAC). This paper proposes a new two-stage structure of direct adaptive multi-resampling turbo equalizer (DAM-TEQ) for solving the problem of large timescale errors in time-varying channels, which uses an innovative adaptive time-domain resampling method for Doppler estimation and compensation. In this equalizer, the received signal is first fed into the first-stage structure, in which an adaptive resampling is performed using equalization coefficient detection to achieve a Doppler rough estimation. After the processing is completed, it is fed into the second-stage structure for joint equalization and decoding, effectively reducing the error of information transmission. Compared with the conventional turbo equalizer (TEQ) based on timescale estimation, the proposed equalizer can avoid the problem of the Doppler Effect not being accurately estimated in time-varying channels, with only a slight increase in complexity. Simulations and lake trails show that the equalizer can effectively perform a Doppler estimation and compensation in time-varying channels, and has a better bit error rate (BER) performance than the traditional timescale-based TEQ.
Adaptive Sliding Mode Trajectory Tracking Control of Unmanned Surface Vessels Based on Time-Domain Wave Inversion
Authors: Mou Tianyu , Shen Zhipeng , Zheng Zixuan
Published: July 2024

In this work, we develop a trajectory tracking control method for unmanned surface vessels (USVs) based on real-time compensation for actual wave disturbances. Firstly, wave information from the actual sea surface is extracted through stereoscopic visual observations, and data preprocessing is performed using a task-driven point cloud downsampling network. We reconstruct the phase-resolved wave field in real time. Subsequently, the wave disturbances are modeled mechanically, and real-time wave disturbances are used as feedforward inputs. Furthermore, an adaptive backstepping sliding mode control law based on command filters is designed to avoid differential explosion and mitigate sliding mode chattering. An adaptive law is also designed to estimate and compensate for other external disturbances and inversion error bounds that cannot be computed in real time. Finally, the feasibility of the proposed control strategy is validated through stability analysis and numerical simulation experiments.
Study on Differences of Metabolites among Different Ganoderma Species with Comprehensive Metabolomics
Authors: Khadbaatar Solongo , Bao Haiying , Gao Xusheng , Huo Huimin
Published: July 2024

In traditional Chinese medicine, Ganoderma is a kind of edible and medicinal mushroom, which is widely used because of its significant pharmacological activity. There are many species within the Ganoderma genus, each with different material bases and applications. However, detailed studies on these species are still lacking. In this study, we investigated the metabolites of G. leacontextum (B), G. lucidum (C), G. tsugae (S) from Changbai Mountain, and G. tsugae (M) from Mongolia using metabolomics. The PCA results indicated minimal differences between M and S, whereas B and S exhibited significant variations. A total of 708 differential metabolites were identified in this study, with steroids, triterpenoids, phenols, and quinones being the major metabolites. Specifically, triterpenoids and steroids were higher in C. Meanwhile, phenolic compounds were more abundant in B. Additionally, quinones were more abundant in M and S. We validated some of the main compounds, and the results showed that paracetamol was most abundant in B, making paracetamol a potential marker for identifying B. Additionally, vitamin K3 was found to be more abundant in M and S, which can serve as a marker for their identification. This study provides new insights and a theoretical basis for the development and utilization of the genus Ganoderma.
Are Mouthwashes Really Effective against Candida spp.?
Authors: Maziere Marie , Rompante Paulo , Andrade José Carlos , Rodrigues Célia F.
Published: July 2024

Oral candidiasis is an opportunistic infection caused by fungi of the genus Candida. Nystatin, fluconazole, and miconazole are the most widely used antifungal drugs in dentistry, but in recent years, they have been shown to be less effective due to the increase in the resistance to antifungal drugs. The growing challenge of antifungal resistance emphasizes the importance of exploring not only alternative strategies in the fight against Candida spp. infections but also supportive treatment for pharmacological treatment for oral candidiasis. This review aims to evaluate and compare the in vitro reports on antifungal efficacy against Candida spp. exhibited by mouthwashes distributed on the European market. The research question was elaborated through the PEO framework recommended by PRISMA 2020. A bibliographic search strategy was developed for the scientific online databases Pubmed and ScienceDirect. According to the eligibility criteria, 21 papers were included in this study over a 27-year period. Mouthwashes containing chlorhexidine digluconate, cetylpyridinium chloride, hexetidine, and fluorine compounds among others, and natural antimicrobials, such as menthol, thymol, eucalyptol, and Glycyrrhiza glabra extracts, have demonstrated antifungal effectiveness. Nonetheless, the methodological variance introduces ambiguity concerning the comparative efficacy of distinct molecules or mouthwash formulations and complicates the evaluation and the comparison of results between studies. Some mouthwashes commercially available in Europe have the potential to be used in anti-Candida therapy and prevention since they have shown antifungal effect.
PCR-Based Microarray Enhances Diagnosis of Culture-Negative Biopsied Tissue in Patients with Invasive Mold Infections: Real-World Experience in a Tertiary Medical Center
Authors: Jan Hao-En , Tsai Chin-Shiang , Cia Cong-Tat , Lee Ching-Chi , Chen Ying-Wen , Lee Nan-Yao , Li Chia-Wen , Li Ming-Chi , Syue Ling-Shan , Lo Ching-Lung , Chang Tsung-Chain , Wu Chi-Jung , Ko Wen-Chien , Chen Po-Lin
Published: July 2024

A fungal polymerase chain reaction (PCR) amplifies conserved genes across diverse species, combined with the subsequent hybridization of amplicons using a specific oligonucleotide microarray, allowing for the rapid detection of pathogens at the species level. However, the performance of microarrays in diagnosing invasive mold infections (IMI) from infected tissue samples is rarely reported. During the 4-year study period, all biopsied tissue samples from patients with a suspected IMI sent for microarray assays were analyzed. A partial segment of the internal transcribed spacer (ITS) region was amplified by nested PCR after DNA extraction. Amplicons were hybridized with specific probes for a variety of mold species using an in-house oligonucleotide microarray. A total of 80 clinical samples from 74 patients were tested. A diagnosis of an IMI was made in 10 patients (4 proven, 1 probable, 3 possible, 2 clinical suspicion). The PCR/microarray test was positive for three out of four proven IMIs, one probable IMI, and one out of three possible IMIs. Two patients with positive PCR/microarray findings were considered to have clinical suspicion of an IMI, and their responsible physicians initiated antifungal therapy despite the absence of supporting microbiological and histological evidence. Clinical diagnoses were categorized into non-IMI and IMI groups (including proven, probable, possible, and clinical suspicion). The sensitivity and specificity of the microarray in diagnosing the IMIs were 70% and 95.7%, respectively, while the sensitivity and specificity of the culture and histological findings were 10%/96.3% and 40.0%/100%, respectively. PCR-based methods provide supportive microbiological evidence when culture results are inconclusive. The combination of a microarray with fungal culture and histology promotes the precise diagnosis of IMIs in difficult-to-diagnose patients.