bluuebunny/crossref_metadata_2025 huggingface dataset:
On the Efficiency Factors of Positive Law
Authors:   North-West Institute of Management of the RANEPA, Sergevnin S.L.
Published: April 2021

The article discusses some of the topical theoretical and legal and philosophical and legal problems of lawmaking. According to the author, the efficiency of the application of legislation in the mechanism of legal regulation directly depends on the quality of lawmaking, including its ideological content and scientific elaboration. Based on the works of reputable lawyers of the past and present, the author convincingly proves that the technique of legislative activity determines the effectiveness of the adopted normative legal acts, the totality of which forms a positive law. Guided by the considerations expressed in the article, the author formulates a number of recommendations aimed at improving the legal, technical and substantive aspects of positive law in order to increase the efficiency of legal regulation.
On the Issue of Holding an Official Sports Event in the Context of the Spread of a New Coronavirus Infection COVID-19
Authors:   Saint Petersburg State University, Afanasev D.A.
Published: April 2021

The subject of the article is the organization and conduct of official sports events in the context of the spread of the new coronavirus infection COVID-19 (hereinafter — COVID-19). The author examines the existing legal regulation in the field of epidemiological safety and the problems that arise during sports competitions, using the example of competitions in St. Petersburg.
Optimizing the Process of Countering the Corruption of Tax Regulations under the Conditions of the Coronavirus Infection Pandemic
Authors:   St. Petersburg Legal Institute (branch) of the University Prosecutor’s Office Russian Federation, Firsov V.V.
Published: April 2021

The present article is devoted to the analysis of corruption in the optimization of the tax laws and regulations. An attempt is made to analyze the limits of the admissibility of anti-corruption regulation of tax legal relations by subordinate legal acts. With the development of public relations, there is an increase, alas, in illegal acts. Corruption is no exception. Thus, its variety is corruption in the field of tax legislation, where corruption poses a threat to the economic security of the country, distorting the system of fiscal state power and management, disrupting market reforms and, accordingly, distorting the law-abiding legal consciousness of Russian society. Individual representatives of the legislative branches of government sometimes use their powers and the rights entrusted to them for personal criminal gain. By its very nature, the verification of the law for compliance with the Constitution of the Russian Federation is addressed to the knowledge of the normative forming grounds of law, followed by a particular economic meaning. The inseparable link between all elements of the legal system and the Constitution of the Russian Federation, supported by the activities of the Constitutional Court of the Russian Federation, does not allow the main priority of the legal social state — constitutional legality, including the optimization of the process of combating corruption, tax rulemaking in the context of the coronavirus pandemic, to disappear.
Banking Cybercrime as One of the Main Problems of Modern Society
Authors:   St. Petersburg Polytechnic Peter the Great University, Kovtun K.A.
Published: April 2021

This article examines the specifics of banking cybercrimes, their victims, as well as criminals who commit these crimes. The research method is based on statistical data from the Bank of Russia. The author concludes that improving the economic and legal literacy of the population is the most effective way to reduce the trend of banking cybercrime.
Foucault’s Concept of Confession
Authors: Büttgen Philippe
Published: April 2021

Setting out from the difficulty of translating the Foucauldian notion of aveu, this paper proposes an account of Foucault’s concept of confession in the years 1979-1983 surrounding the writing of Confessions of the Flesh. I focus on Foucault’s relative failure to bring together the complementary dimensions of confession as confession of sins and confession of faith in early Christianity. Foucault’s attempts to tackle this challenge nonetheless reveal a number of crucial aspects of his thought throughout the 1970s, e.g., the critique of the notion of ideology and the role that critique played in the setting of Foucault’s “critical philosophy of veridictions”. A comparison with the lectures given at Louvain and the Collège de France suggests that Foucault took an original and rather solitary path in Confessions of the Flesh, which may explain the surprises awaiting the reader. Finally, I propose an explanation of Foucault’s final shift away from Christian confession towards Greek parrhesia, pointing to the key role of the idea of a “duty of truth”. This idea led Foucault to an original approach to confession and the illocutionary force of statements.
Primer registro de Meriana sanguinea Wurdack para la provincia de Tungurahua, Ecuador
Authors: M Giovanni Romo Rojas
Published: April 2021

INTRODUCCIÓN: Meriania sanguinea es una especie poco conocida en el Ecuador, su hábitat secircunscribe a bosques montanos de la cordillera oriental de los Andes.OBJETIVO: Reportar la presencia de M. sanguinea en la provincia de Tungurahua ampliando el área dedistribución de la especie en Ecuador.METODOLOGÍA: El registro se fundamenta en la observación de tres individuos de M. sanguinea, en lascoordenadas 01°11’24,4” S y 78°28’46,6” W. La identificación de las características morfológicas de laespecie se la realizó mediante registro fotográfico, colecta de muestras, análisis en herbario y uso de fuentesbibliográficas.RESULTADOS: Se localizaron tres individuos entre uno y cinco metros de altura en un bosquefragmentado por la presión antrópica. El de mayor altura presentaba estructuras reproductivas quefacilitaron la identificación de la especie.CONCLUSIONES: Se amplía el rango de distribución geográfico de M. sanguinea a la provincia deTungurahua. Este constituye el primer registro de la especie en la zona central del Ecuador.
Hypothesis article: Nitric oxide depletion may aggravate COVID-19 symptoms.  A new therapy could help
Authors: Daams Brecht
Published: April 2021

The Corona virus SARS-CoV2 that causes COVID-19 has effects that until
now have not been explained. The widespread damage of SARS-CoV2, the
comorbidities in critically ill COVID-19 patients, and the symptoms of
post-COVID-19 patients show striking similarities with conditions that
are related to depletion of nitric oxide (NO) in the human body. Many of
the symptoms of the disease may be caused by acute depletion of NO by
the immune system. Patients with the highest COVID-19 burden often have
comorbidities that are related to chronic depletion of NO. Post-COVID-19
health problems may be caused by earlier depletion of NO. Successful
therapy requires sufficient NO levels. Supplementation with NO will
increase immunity, help prevent thrombosis, and improve breathing,
kidney functions, blood flow and oxygenation in patients, elderly
patients and patients with comorbidities in particular. Furthermore, NO
helps to prevent SARS-CoV2 from entering the human cell and to suppress
viral RNA production. NO is not easy to supplement. A few SARS patients
have been treated with inhaled NO with positive results, but inhaled NO
can only deliver small quantities of NO. A new therapy has been
developed to more effectively supplement NO. It combines the ingestion
of nitrates (as NO donor), N-acetylcysteine and vitamin C (promoting NO
metabolism) with electrostimulation of the muscles (to trigger the
release of NO). It is expected that this therapy can ease the most
serious symptoms of (post) COVID-19, especially for elderly and people
with comorbidities. A patent has been applied for.
La stato di qualità ambientale dei fiumi: il legame ossigeno-acqua
Authors: Barbati Domenico , Erra Luigi
Published: April 2021

L’elaborato ha il compito di descrivere come l’ossigeno disciolto nei
corsi d’acqua sia un parametro estremamente rilevante per la
caratterizzazione qualitativa del comparto idrico. Dopo aver fatto una
panoramica dal punto di vista normativo che contraddistingue tale
comparto e aver descritto brevemente le tipologie di analisi che lo
caratterizzano, ci si è focalizzati sulla caratterizzazione qualitativa
dell’acqua. Tale caratterizzazione è stata effettuata descrivendola in
primis dal punto di vista normativo, sia europeo che nazionale e
successivamente individuando un indicatore, l’ossigeno disciolto, per
determinare la qualità. Infine, utilizzando sempre come punto di
riferimento l’ossigeno si è descritto brevemente due modelli utilizzati
per la modellazione qualitativa dei corsi d’acqua: il Modello Streeter
& Phelps e il Modello Qual2k.
Un fenomeno "potenzialmente" pericoloso per la salute pubblica: Le Radiazioni ionizzanti e non
Authors: Gioia Giammarco , Mirra Alessia
Published: April 2021

Le radiazioni sono un fenomeno di emissione di energia sotto forma di
onde, quest’ultime possono essere: luminose, elettromagnetiche o sonore.
Le onde elettromagnetiche vengono distinte, in funzione della frequenza
e dell’energia,in radiazioni ionizzanti e radiazioni non ionizzanti.

Le radiazioni ionizzanti sono dotate di un’energia sufficiente a
liberare elettroni da atomi, mentre le radiazioni non ionizzanti sono
radiazioni elettromagnetiche che non trasportano sufficiente energia per
ionizzare atomi e producono principalmente effetti termici.

Nel caso studio da noi analizzato evidenziamo un’importante questione da
affrontare: il monitoraggio delle fonti di emissione. Quest’aspetto è
diventato sempre più rilevante poiché siamo costantemente immersi in
campi generati dai dispositivi elettronici.

Lo scopo finale di tale indagine è sia quello di evidenziare eventuali
problemi per la salute dei cittadini sia quello di descrivere il quadro
normativo vigente in materia e le fasi metodologiche per l’analisi di
questo comaparto in fase di redazione di Studio d’Impatto Ambientale.
Struttura e contenuti del Rapporto Ambientale
Authors: Pepe Raffaele , GIUGLIANO SALVATORE , Sabatino Giuseppe
Published: April 2021

Il rapporto ambientale sulla valutazione ambientale strategica (VAS), è
il documento che individua tutti gli impatti positivi e negativi sul
territorio del piano, sviluppando delle possibili alternative di
miglioramento, tenendo in considerazione le esigenze del territorio
stesso. Questo documento permette di avere una panoramica dedicata ai
contenuti principali del piano ed un’analisi dell’opzione ‘’0”, intesa
come l’evoluzione del territorio senza l’attuazione del piano. L’analisi
vera e propria consiste nell’esaminare le caratteristiche ambientali,
culturali e paesaggistiche per poi verificarne gli impatti provocati dal
P.U.C. sull’ambiente, con l’obiettivo di mitigarli. È importante non
trascurare i processi di monitoraggio sulla mitigazione degli impatti
negativi, affinché vengano rispettati gli standard qualitativi e
quantitativi degli obiettivi preposti.
The use in pediatrics of recombinant interferon alfa-2b preparations in the dosage form rectal suppositories: whom? when? which ones?
Authors: Savenkova M. S. , Savenkov M. P.
Published: April 2021

The paper presents the indications and main differences of frequently used rectal suppositories containing interferon alpha-2b.The features and differences in the contained excipients are highlighted. A range of diseases in children's practice is presented, in which candles are shown VIFERON®, Kipferon®, Genferon light®
Abordagens fonte-mar e de paisagem : Integração da qualidade da água e conservação da biodiversidade na restauração da bacia do Rio Doce
Authors: Barbosa M.C.W. , May F.A.R. , Maroun C. , Renshaw J. , Sánchez L.E. , Kakabadse Y.
Published: April 2021

O relatório traz informações e dados selecionados sobre a qualidade física, química e biológica da água e uma visão geral da biodiversidade terrestre, de água doce e marinha na bacia do Rio Doce desde o rompimento da barragem até o momento atual. Também apresenta uma revisão das abordagens integradas já adotadas nas ações de restauração do Rio Doce, com foco nos programas do Termo de Transação e de Ajustamento de Conduta, cuja concepção incorpora, em alguns aspectos, as abordagens fonte-mar e de paisagem. O Relatório aponta caminhos para a criação de uma abordagem conjunta para restaurar a qualidade da água e a biodiversidade na bacia do Rio Doce, aproveitando as ações já implementadas pela Fundação Renova e seus parceiros.
Operating Cash Flows and Earnings Target Revision: Evidence from Annual Cash Bonus Plans for CEOs
Authors: Li Laura Yue , Wang Shuyang , Zhu Wei
Published: April 2021

We empirically examine the impact of operating cash flows on future earnings targets in CEOs' annual cash bonus plans. Using target and actual compensation earnings-per-share disclosed in proxy statements of large U.S. public firms, we find operating cash flows have no significant incremental effects on the revision of future earnings targets in the presence of current earnings. We observe a positive association between future target achievability and current operating cash flows, indicating that firms with higher operating cash flows set significantly easier future earnings targets for CEOs. These findings suggest that the higher persistence of operating cash flows in predicting future earnings is not fully incorporated into target setting. Further analyses reveal that the positive association between future target achievability and current operating cash flows is attributable to both expectation bias and contractual considerations to reward CEOs who deliver greater cash flows and to limit activities that sacrifice cash flows.

Data Availability: Data are publicly available from sources identified in the article.

JEL Classifications: M41; J33.
Why is Corporate Virtue in the Eye of The Beholder? The Case of ESG Ratings
Authors: Christensen Dane M. , Serafeim George , Sikochi Anywhere
Published: April 2021

Despite the rising use of environmental, social, and governance (ESG) ratings, there is substantial disagreement across rating agencies regarding what rating to give to individual firms. As what drives this disagreement is unclear, we examine whether a firm's ESG disclosure helps explain some of this disagreement. We predict and find that greater ESG disclosure actually leads to greater ESG rating disagreement. These findings hold using firm fixed effects and using a difference-in-differences design with mandatory ESG disclosure shocks. We also find that raters disagree more about ESG outcome metrics than input metrics (policies), and that disclosure appears to amplify disagreement more for outcomes. Last, we examine consequences of ESG disagreement and find that greater ESG disagreement is associated with higher return volatility, larger absolute price movements, and a lower likelihood of issuing external financing. Overall, our findings highlight that ESG disclosure generally exacerbates ESG rating disagreement rather than resolves it.

Data Availability: The data used in this study are publicly available from the sources cited in the text.

JEL Classifications: G24; M14; M41; Q56.
Freedom of Expression in Russia’s New Mediasphere
Authors: Nygren Gunnar
Published: April 2021

Gunnar Nygren, professor emeritus at Södertörn University, Stockholm,  reviews Freedom of Expression in Russia’s New Mediasphere edited by Marielle Wijermars and Katja Lehtisaari.
Tuition fees, entrance examinations and misconceptions about equity in higher music education
Authors: Jääskeläinen Tuula
Published: April 2021

The increasing participation rate in higher education has raised its own issues, such as how to fund the growth while retaining the quality of education. In Finland, it has been argued that the tuition-free higher education policy increases equality. On the other hand, in the United Kingdom, establishing a system of tuition fees supported by an income-contingent loan system for students has also been argued to increase equality. In Australia, students also face high tuition fees for higher education, as well as a support system focused on domestic students. In addition to tuition fees, entrance examinations also play a crucial part in higher education systems. In order to examine inequalities in higher education from the students’ point of view, tuition fees are scrutinised in connection with equality, and entrance examinations in relation to cultural reproduction. Comparing examples of higher music education institutions in Finland, the United Kingdom, and Australia shows that there are large differences between the tuition fees charged for domestic and international students, as well as between countries. Entrance examinations in higher music education are similar in these countries, but may include inequalities based on long traditions in the field of music, especially in classical music. By revealing misconceptions about equity in higher education, it is possible to have a critical debate about the role of tuition fee systems as they are connected with the economics of higher education, and about entrance examinations as reproducing social class inequalities. This discussion may contribute to the redefinition and reformation of more equitable and just education systems, and promote equality in general in society.
Hvordan kan kunnskap om tekstlesing og lese- og skriveopplæring i grunnskolen brukes i noteopplæring på nybegynnernivå?
Authors: Leikvoll Julia Katarzyna
Published: April 2021

Denne teoretiske artikkelen drøfter mulighetene for hvordan kunnskap om leseprosessen og lese- og skriveopplæringsmetoder brukt i den norske grunnskolen kan anvendes for noteopplæring i instrumentalundervisning på nybegynnernivå, der vestlig tonal musikk ligger i fokus. Tekstlesing og notelesing synes å ha mange fellestrekk som kognitive prosesser. Gjennomgang av undervisningsmetoder i språk- og notelesing viser imidlertid flere grunnleggende forskjeller, som vektlegging av ulike metodiske elementer, progresjon i innføring av nye skrifttegn, samt valg av undervisningsaktiviteter. Artikkelen beskriver språklig og musikalsk syntaks og lesing som en kognitiv prosess, og sammenlikner populære læreverk brukt i leseopplæring i Norge i henholdsvis språk og musikk. I diskusjonsdelen blir det argumentert for at bruk av undervisningsaktiviteter som tar i bruk skriving, erfaring med klingende musikk før noteskriften introduseres, introduksjon av grunnleggende harmonilære samt tilpassing av læreverkenes layout kan ha positiv effekt på utvikling av notelesingsferdigheter på nybegynnernivå.
English abstract
English title: How can knowledge about language learning and teaching be used to enhance the study of music reading at the beginner level?
This theoretical article aims to discuss the possibility of using teaching methods for reading and writing used in Norwegian primary schools for teaching literacy for music notation to instrumental pupils at the beginner level, focusing on western tonal music. Language and music reading have much in common as cognitive processes. However, comparison of methods for teaching how to read language and music shows several fundamental differences. They relate to the emphasis on various methodological elements, progression in the introduction of new symbols and choice of the activities used in the teaching/learning process. The article describes musical and linguistic syntax, acquisition of reading skill as a cognitive activity, and compares popular method books for teaching reading text and music in Norway. In the discussion section it is argued that the teaching activities that use writing music, experiencing various elements of music as sound before introducing musical notation and introducing basic knowledge about harmony, as well as adjusting of layout in the books for beginners, will have a positive effect on sight-reading at the beginner level.
Co-constructing an intercultural professional learning community in music education
Authors: Timonen Vilma
Published: April 2021

This participatory action research aims to contribute to a better understanding of the advantages and complications involved in intercultural educational development work in the field of music education. The inquiry focuses on Finnish and Nepali music educators’ collaborative activities in the period 2013–2016 aimed at establishing a music teacher education program in Nepal. The collaboration is examined through the theoretical concept of a professional learning community (PLC). Particular interest is placed on illustrating the nature of the professional learning that took place for the participating teachers during the development of the intercultural PLC. The findings point towards recognizing the importance of supporting systematic collaborative operational models within and between institutions, as they hold the potential for constructing reflective, ethically engaged, and diversity-aware music education – the kind of education that is needed in these rapidly changing times.
Editorial
Authors: Johansen Guro Gravem , Houmann Anna , Treacy Danielle Shannon
Published: April 2021

This first issue of volume 2 of NRME Journal encompasses nine research articles addressing a variety of themes relevant to music education. They are all loosely connected through the notion of space: how we physically, metaphorically or virtually inhabit musical spaces; the tools that are needed for entering a music knowledge domain or space; the thresholds that exist for accessing educational spaces; and the ways various professional spaces in music education facilitate learning and identity formation, as well as cultural reproduction and power battles.
Social Technology (TS) and Artificial Intelligence (AI)… Brief Reflections and Perspectives
Authors: Bomfim Felipe Rodrigues
Published: April 2021

The purpose of this article is to reflect the possible connections between Social Technology (TS) and Artificial Intelligence (AI), in an attempt to understand some limits and possibilities in the contemporary world. Is it possible to envision any articulation between ST and AI in the health area? What would be the gains and social impacts of this possible articulation? It is these concerns that we intend to reflect on. The article is divided into two moments. In the first moment, we contextualized Social Technology (TS) and Artificial Intelligence (AI). In the second and last moment we present the Artificial Partner Technology (TSA), its meaning and perspectives.
Virtuous Physician: Indonesian Perspective
Authors: Kusmaryant Carolus Boromeus
Published: April 2021

Physicians are virtuous profession because they deal with life and death and especially with vulnerable persons. It is a humanity profession. To be good physicians need to have high standard of compassion and care (virtue). Medical virtues have to be taught in the faculty of medicine so that the alumni have virtuous character. In their lives as physician, there are many regulations to maintain the application of virtue in their services. Unfortunately, now the erosion of virtues becomes more apparent. Some physicians are more profit-oriented rather than humanity-oriented.
The Origin of the Social Transformation of Care
Authors: Maza Daniela Verónica
Published: April 2021

The present work explores the factors that led to the change in social behavior to provide care. The results obtained in a qualitative investigation carried out in the City of Buenos Aires on the familiarization and judicialization of the care of people with disabilities is shown. Deepening the origin of the transformation of care based on the factors (objective and subjective) that promoted the change contributes to the identification of the causes that generated the self-care deficit presented by the people who care.
Introductory Aspects on Human Rights Violations Suffered by Indigenous Peoples during the Period of Brazilian Civil-Military Dictatorship
Authors: Chuquel Luane Flores
Published: April 2021

This current work studies the human rights violations suffered by indigenous peoples during the period of the Brazilian CivilMilitary Dictatorship. Likewise, it makes some notes about the beginning of the violations in a moment before this dark period. On this path, even before the Military Coup was launched in the year 1964 (one thousand nine hundred and sixty-four), the Indians were already experiencing constant usurpations of their rights at the expense of irresponsibilities commanded most of the time, by those who should watch over their rights lives. As will be seen, the violation and disrespect for Human Rights in the face of these peoples ended up becoming common and gaining strength mainly in the beginning of the implementation of the military regime. Negligent attempts at acculturation and "emancipation", in addition to inconsequential contacts with isolated peoples, culminated in the destruction and predatory logging of their lands. Missing processes of terribly violating demarcations of indigenous areas promoted the expulsion of countless peoples, causing the Indians to fall into a life totally surrounded by hunger, begging, alcoholism and prostitution. All in the name of the so-called “economic advance”, which aimed at building roads, in what was called “occupation of the Amazon”? As frequently stated by the authorities at the time, the Amazon rainforest was seen and understood as a “population void” by the Military Government. According to this thought idealized by the disgusting dictators and supporters, it will be observed that the cases of violations of Human Rights have been systematically “legalized”. The life, land and culture of indigenous peoples were left in the background. Depending on this brief narrative developed through documentary research, based on a hypothetical-deductive method, the intention is to rescue the martyrdoms of that time, demonstrating what actually happened to indigenous peoples during the Military Regime, in the simplest attempt to remember or even disclose to those who are unaware of this part of history. All that said, don't you forget. So that it never happens again.
The Internet and Cancellation Culture: The Impact of the Public Opinion on the Exercise of the Individual Right to Freedom of Expression
Authors: Silva Santos Elaine Celina Afra da
Published: April 2021

This article analyzes the impact of the culture of cancellation promoted by users of social networks on the exercise of individual rights, more precisely Freedom of Expression. The study presents the analysis of the content inherent to what would be the cancellation, its aspects and practical consequences in the individual sphere of the users. The theme is approached by the deductive method and through doctrinal research. The article intends to answer if there are legal consequences resulting from the use of this resource by users.
"Tendo conquistado o presente, a direita traz consigo a vitória do futuro": O neoconservadorismo anglo-saxónico e a evolução do pensamento económico da direita radical portuguesa (1976-1985)
Authors:   CITCEM/FLUP, Madeira Bruno
Published: April 2021

The electoral victories of neoconservatism in the United Kingdom and the United States of America had evident impacts on the European right, namely in terms of their revitalization and organizational, discursive, doctrinal and prepositive updated stance. In the case of the Portuguese radical right, this influence and moralizing example are clear. Ostracized and kept in political marginality after the Revolution of April 25, 1974, Portuguese right-wingers saw in the advances of neoconservatism the possible way to rehabilitate themselves in democracy and, at the same time, to accommodate their old principles to a fashionable political-economic narrative.
The analysis of the sensitivity of vaccination parameters in a tuberculosis transmission model
Authors: Chasanah Siti Laelatul , Ferdias Pandri , Nurvazly D E
Published: April 2021

Tuberculosis (TB) is one of the most dangerous infectious diseases that caused 1,5 million people died from TB in 2018 (including 251.000 people with HIV). As the preventive strategy for the spread of TB, we can use BCG vaccination. This study aims to investigate and analyze the sensitivity of vaccination parameters (to newborns and adults). This model divided the human population into five classes: susceptible , vaccinated , high-risk  and low-risk  latent, and infectious . Analysis of the mathematical model was discussed by finding the existence and analyzing the model equilibrium's stability based on the Basic Reproduction Number ( ).  Furthermore, we determined the sensitivity analysis of the proportion of vaccine and other parameters that affect the TB transmission model. The numerical experiment shows that vaccination to adults more effective than newborns.
Confidence interval estimation of gamma distribution lifetime data using score and bootstrap methods
Authors: Larasati Larasati , Ruswandi Rudi , Fitriani Fitriani
Published: April 2021

Confidence interval estimation of parameters determines the value interval, which is calculated based on statistical measurements and has specific estimates probability that contains the actual parameters. A method is needed to estimate the parameters' confidence interval, and the methods used are the Score method and the Bootstrap method. This study aims to estimate parameters by using the maximum likelihood estimation method and analyze the reliability of the aircraft engine cooling system's lifetime that follows the Gamma Distribution, and estimate the confidence interval of the parameters.
Associação de preenchedores e bioestimuladores no rejuvenescimento facial - relato de caso
Authors: Lages Renata Bandeira , Alencar Érika Dayane Maia , Oliveira Yves Viana Ramalho
Published: April 2021

With increasing age, the dermis and epidermis begin to suffer a progressive loss of mitochondrial activity and collagen. In women, it is common to experience changes due to hormonal imbalance or exposure to Ultraviolet rays, causing the appearance of wrinkles, depigmentation, flaccidity, and others. Patient dissatisfied with the aged aspect, sagging and loss of volume of the zygomatic region on his face. It has been associated with the application of hyaluronic acid and polycaprolactone (PCL) in different areas of the face, highlighting their contributions to the rejuvenation process. Effectiveness and safety were concluded by associating the application of hyaluronic acid and PCL, with immediate satisfactory effect on the contours and shapes of the face.
Aplicação mínima de ácido hialurônico para volumização labial - relato de caso
Authors: Lages Renata Bandeira , Formigieri Aurinete da Silva Borges , Miranda Bruno Estevam de Carvalho , Oliveira Yves Viana Ramalho
Published: April 2021

It is a great challenge to establish aesthetic excellence creating harmony between beauty and the function of the smile with the delicacy and complexity of the lips and components of the face. The use of soft tissue fillers with hyaluronic acid is a worldwide popular and minimally invasive procedure based on numerous studies. Due to its relative simplicity and favorable security profile, it is becoming easy to accept. The present case report aims to describe the lip filling technique, using a total volume of 1 ml of hyaluronic acid, to improve the patient’s aesthetic dissatisfaction. The result was satisfactory, with minimal side effects and optimizing the patient’s self-esteem.
A importância da Harmonização Orofacial no resultado final das lentes de contatos
Authors: Correa Ana Karina Fonseca de Carvalho Calderan , Tavares Leonardo Nogueira , Celória Antonio Aparecido
Published: April 2021

This paper aimed to address smile rehabilitation, returning aesthetics and function using dental contact lenses with conservative preparations. Sometimes the use of contact lenses, despite completely improving teeth aesthetics, is unable to solve all the aesthetic needs for complete oral harmonization, for example, the black spaces that impair smile aesthetics. In this paper we will show how it is possible to correct interdental papillae using hyaluronic acid, complementing the aesthetic gain, raising self-esteem and bringing the perfect smile desired by the patients.
Promoting resilience through bibliotherapy in children experiencing the coronavirus pandemic
Authors:   , Koon Rena
Published: April 2021

This project will examine the emerging literature related to the coronavirus disease pandemic, its potential effects on the mental health of children and factors promoting resilience in this population. The culmination of this work will be a series of interventions utilizing bibliotherapy to help foster resilience in children. These interventions are intended to be used by school counsellors, mental health professionals, teachers or parents, as well as with small groups or large groups of children. The project will be divided into five sections with each section focusing on a principle that helps promote resilience in children following a mass trauma. Each section will consist of an explanation of the principle, a book choice, interventions that could be initiated by a mental health professional, a teacher, or a parent followed by an annotated bibliography of additional books that could be utilized to support this principle.
Supporting grieving children: Dragonfly Dance
Authors:   , Kristinsson Patricia
Published: April 2021

The following is a synthesis of the literature focused on ways of supporting healthy grieving in children and a related children’s book based on the findings. I have produced a book on grieving that is intended to be used by caregivers and educators to support bereaved children. The support strategies that are discussed here and reflected in the book Dragonfly Dance include ideas from traditional therapeutic approaches, expressive arts, pet therapy, grief camps, adventure therapy, and group therapy. The tasks of grieving are also described through selected literature. Dragonfly Dance incorporates many of the known activities that support transition through grief.
Narrative literature review and gap analysis of diabetes services in a community setting
Authors:   , Shaw Jennifer
Published: April 2021

The goal of this project was to outline best practices regarding the organization of diabetes care and services in the community in relation to the local context of services in Squamish, BC, Canada to create a foundation for future quality improvement work. The theoretical framework of personcentered care is essential to chronic disease management and underpins this work. The methods include: 1) A narrative literature review consisting of a database search, and 2) A gap analysis consisting of local data and an environmental scan. The Chronic Care Model is an evidence-based integrated care framework used to organize the findings of the narrative literature review and the gap analysis and to frame the recommendations (Clement et al., 2018). Based on the findings, evidence-based recommendations were created specific to the context of diabetes care in Squamish, BC creating the opportunity for meaningful future quality improvement work.
Continuidad de los vínculos familiares: impacto de las resoluciones judiciales en violencia familiar
Authors: Losada Analia Veronica , Caruso Jorge Mario
Published: April 2021

La violencia intrafamiliar es un acontecer psicosocial trascendente para la sociedad en su conjunto. El espacio judicial se constituye como el único recurso, que debería ser el último, de contención y morigeración de los efectos devastadores de la violencia. El objetivo de este trabajo es describir las consecuencias producidas por la intervención judicial en los casos de violencia familiar, sometidos a la consideración de los jueces de familia, sobre la integridad psicosocial del vínculo parental. Se llevó adelante un estudio mixto que incluyó 453 encuestas a universitarios y diez entrevistas en profundidad a jueces. Los resultados muestran que la imposición de la ley es restrictiva respecto de los vínculos familiares y produce efectos negativos en la continuidad de vínculos parentales, siendo los niños los más damnificados y afectados en virtud de su involuntario involucramiento.
A ecologia e a antropologia no Papa Francisco: uma leitura à luz de Habermas acerca da tolerância religiosa
Authors: Silva Nelson Maria Brechó , Junior Agnaldo Costa
Published: April 2021

O presente artigo analisa a dimensão teológica da cultura ecológica na carta encíclica Laudato Sí. O objetivo é propor uma teologia da ecologia cristã a partir da denúncia do progresso tecnológico em diálogo com as Ciências da Religião e com a Filosofia a respeito da tolerância religiosa no Estado liberal. A reflexão se dará em quatro momentos. No primeiro, propõe-se examinar os nº 106-14 da Laudato Sí no tocante ao paradigma tecnocrático, mostrando os limites da tecnologia. No segundo, elucida-se a teologia cristã sobre a ecologia presente na ideia da cultura ecológica. No terceiro, averígua-se a análise do antropocentrismo moderno, segundo a leitura que o Papa Francisco realiza, a partir do pensamento de Romano Guardini de que a razão técnica se encontra acima da realidade e do meio ambiente como “casa comum” nos nº 115-121 da Laudato Sí. No quarto e último momento, explora-se a união da Ecologia com a Antropologia no âmbito da preservação da “casa-jardim”, especialmente na obra “Vida após a pandemia”, de 2020, de autoria do Papa Francisco. Além disso, procura-se fazer uma leitura filosófica a partir de Habermas acerca das comunidades religiosas buscando traduzir a sua mensagem na esfera pública a fim de que façam parte da sociedade pós-convencional como comunidades razoáveis. O resultado a ser obtido consiste em demonstrar luzes diante do cenário pandêmico.
Optimización de reactores anaerobios continuos para tratamiento de aguas residuales
Authors:   , Mora Vázquez Alejandro
Published: April 2021

El tratamiento de aguas residuales de procesos industriales es un tema de gran interés académico e industrial. Por una parte, la complejidad de las aguas residuales y su posible tratamiento es de gran interés científico. Por otra parte, debido a las restricciones ambientales cada vez mayores, las industrias están obligadas a implementar sistemas de tratamiento de aguas residuales. De los distintos tipos de tratamiento de aguas que se aplican para aguas residuales industriales, los procesos biológicos, y en particular la digestión anaerobia, son atractivos debido a su capacidad para tratar aguas residuales con alta carga orgánica y generar como subproducto del tratamiento biogás. La operación tradicional de digestores anaerobios se puede mejorar a través de la optimización de procesos. En el presente trabajo se formulan dos problemas de optimización para dos casos de estudio. Los problemas de optimización se formulan con base a un enfoque convencional de programación no-lineal y un enfoque no convencional basado en la teoría de sistemas bioquímicos. El primer caso de estudio consiste en un modelo de un digestor anaerobio tipo CSTR de cuatro estados, que tiene aplicación en el tratamiento de aguas residuales provenientes del proceso de producción de tequila. El segundo caso de estudio consiste en un modelo genérico de un digestor anaerobio tipo CSTR de siete estados.
O DIREITO À INFORMAÇÃO FRENTE À PROTEÇÃO INTERNACIONAL DE DIREITOS HUMANOS
Authors: Camargo Ruth Da Paz , Barreto João Francisco De Azevedo , Sousa Marco Aurélio Batista de
Published: April 2021

A pesquisa, vinculada ao grupo de pesquisa e estudos em gestão da sustentabilidade organizacional, junto ao CNPQ/UFMS/CPTL, tem por escopo o direito à informação como um direito humano; desenvolveu-se sob a contextualização dos direitos humanos, do princípio da transparência, e da participação social no combate à corrupção. Abordar-se-á a problemática do acesso às informações públicas, que apesar de seu reconhecimento em documentos internacionais, ainda demonstra precariedade quanto à acessibilidade e participação social na governança pública. Discorrer-se-á sobre esta temática, procedendo ao resgate de documentos internacionais oriundos da Organização das Nações Unidas e de organizações internacionais regionais de proteção aos direitos humanos, sendo esses a essência normativa do direito à informação. Objetiva relacionar o direito à informação à proteção internacional dos direitos humanos. Justifica-se pelo fato do acesso à informação constituir um direito fundamental, implicando na obrigação objetiva dos Estados de garantir o acesso às informações, pautando-se no princípio da transparência. Utilizaram-se como métodos de pesquisa, quanto à abordagem, natureza, objetivos e procedimentos, as metodologias: qualitativa, descritiva e bibliográfica. Constatou-se que, originalmente, o direito à informação, era vinculado ao direito à liberdade de expressão; e que com o avanço jurisprudencial e a adoção de novos documentos internacionais, tornou-se um meio para a realização de outros direitos, adquirindo autonomia, além de tratar-se de ferramenta fundamental de participação social no combate à corrupção. A pesquisa sugere que o investimento na promoção cultural do direito à informação, como instrumento de cidadania, fortalece a consolidação da democracia, sendo inerente aos direitos humanos
O SALÁRIO MÍNIMO FEDERAL E AS FAMÍLIAS BRASILEIRAS: ESTUDO COMPARATIVO DO PODER DE COMPRA NOS ANOS DE 1995 E 2015
Authors: Pinto Maikol Nascimento , Dos Santos Lucas Almeida
Published: April 2021

O presente artigo tem por objetivo estudar e demonstrar se houve alterações no poder de compra de famílias brasileiras que viveram com até um salário-mínimo federal, com foco nos anos 1995 e 2015. Além disso, pretende visualizar os gastos médios das famílias brasileiras em cada um desses anos, ou seja, comparar se em 2015 as pessoas compraram mais itens com um salário-mínimo em relação ao ano de 1995 e por fim, verificar se as políticas de aumentos nos salários-mínimos fizeram o poder de compra aumentar nos anos citados. Metodologicamente, a pesquisa tem caráter qualitativo, construído a partir de bibliografias e dados socioeconômicos, coletados em sites de institutos de pesquisas e relatos, os quais corroboraram à pesquisa em relação à destinação dos valores gastos nos períodos citados. Após analisar os objetivos específicos da pesquisa e realizar as comparações chegou-se aos seguintes resultados: houve alterações no poder de compra das pessoas que viveram com até um salário mínimo entre os anos de 1995 e 2015. Finalmente foi percebido que os aumentos federais colocados na prática contiveram os aumentos dos preços entre esse período e mesmo o salário mínimo de 2015 tendo que dar conta de mais bens de consumo do que o salário mínimo de 1995, ele se sobressaiu. Além disso, a internet, em 2015 já caracterizava, diferente de 1995, novas maneiras de consumir, tanto serviços, a exemplo de conteúdos disponibilizados em plataformas streaming e/ ou produtos comercializados por e-commerce.
EXPECTED COMPETENCES IN STARTUPS: PERCEPTIONS OF ENTREPRENEURS
Authors: Stettiner Caio Flávio , Lima Ednício Oliveira , Bianchi Eliane Pires Giavina
Published: April 2021

Based on theoretical models, such as those proposed in the studies of McClelland and Spencer and Spencer over the last forty years, this study identifies entrepreneurs’ perception of the impact of the required skills of a job applicant in startups. It uses the snowball sampling technique and direct observation in incubators and accelerators to conduct a qualitative analysis. Semi-structured interviews were conducted with the founders and managers of different impact ventures. From the analysis and discussion of this research, some of the skills required in startups are empathy, principles, ethical values, and other attributes of human nature. This study will be of practical value to job seekers, recruiters, and scholars as it suggests the skills that are required in the high-impact market, helping to develop better recruitment and training programs to their business.
Molecular structure of stress granules and their role in the eukaryotic cell
Authors: Pietras Paulina , Leśniczak Marta , Sowiński Mateusz , Szaflarski Witold
Published: April 2021

Stress granules (SGs) are cytoplasmic structures found in eukaryotic cells, from yeast to human cells. They are made up of proteins, RNA and small ribosome subunits (40S). They arise as a result of the rapid shutdown of active protein biosynthesis in the cell, which is the result of the appearance of a stress factor. The mechanism of regulation of protein biosynthesis in response to stress takes place at two control nodes: (1) phosphorylation of the α subunit of the eIF2 factor as a result of the action of stress-recognizing kinases or by modulation of the mTOR pathway activity, which regulates the initiation of protein biosynthesis by the formation of a complex within the so-called cap structure. The protein arrest causes aggregation of the translation process components and other cell components (other proteins or mRNA molecules) into SGs. A lot of data indicates the active participation of SGs in metabolic processes, their control role over pro- and anti-apoptotic processes as well as in the development of cancer, neurodegenerative diseases and their defensive role in viral infections.

Running title: Stress granules in the cell
Pharmacokinetics study of a supersaturatable self-microemulsifying drug delivery system for ellagic acid by UHPLC-Q-TOF-MS
Authors: Wang Jinglong , Fan Liqun , Zhang Lihua , Zheng Dandan , Wang Yingzi , Sun Xiao , Ji Yonghui
Published: April 2021

To evaluate the bioavailability of ellagic acid loaded super-saturatable self-microemulsifying drug delivery system (S-SMEDDS), its pharmacokinetic properties were studied in rats with an ultra-high performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry. The plasma samples were treated by solid-phase extraction method, and gallic acid was used as the internal standard when determining the concentration of ellagic acid. Results showed that the established analytical method was sensitive and accurate, which is applicable to the pharmacokinetic study of ellagic acid. The drug was found to be absorbed rapidly in vivo, and the plasma concentration-time curve showed double peaks, indicating that ellagic acid were reabsorbed by entero-hepatic circulation after oral administration. Compared with ellagic acid suspension, the apparent clearance of ellagic acid-loaded S-SMEDDS and SMEDDS reduced significantly, and the AUC
0~t of them were 4.7 and 5.8-fold increase, respectively. Therefore, the bioavailability of ellagic acid-loaded S-SMEDDS was higher than that of the suspension and SMEDDS.
Recent advancements to enhance the therapeutic efficacy of antiepileptic drugs
Authors: Li Fuquan , Singh Akhilesh Vikram
Published: April 2021

Epilepsy is a multifactorial neurological disorder characterized by recurrent or unprovoked seizures. Over the past two decades, many new antiepileptic drugs (AEDs) were developed and are in use for the treatment of epilepsy. However, drug resistance, drug-drug interaction and adverse events are common problems associated with AEDs. Antiepileptic drugs must be used only if the ratio of efficacy, safety, and tolerability of treatment are favorable and outweigh the disadvantages including treatment costs. The application of novel drug delivery techniques could enhance the efficacy and reduce the toxicity of AEDs. These novel techniques aim to deliver an optimal concentration of the drug more specifically to the seizure focus or foci in the CNS without numerous side-effects. The purpose of this article is to review the recent advancements in antiepileptic treatment and summarize the novel modalities in the route of administration and drug delivery, including gene therapy, for effective treatment of epilepsy.