bluuebunny/crossref_metadata_2025 huggingface dataset:
Data from SLX4IP Promotes Telomere Maintenance in Androgen Receptor–Independent Castration-Resistant Prostate Cancer through ALT-like Telomeric PML Localization
Authors: Mangosh Tawna L. , Awadallah Wisam N. , Grabowska Magdalena M. , Taylor Derek J.
Published: April 2023

Abstract
In advanced prostate cancer, resistance to androgen deprivation therapy is achieved through numerous mechanisms, including loss of the androgen receptor (AR) allowing for AR-independent growth. Therapeutic options are limited for AR-independent castration-resistant prostate cancer (CRPC), and defining mechanisms critical for survival is of utmost importance for targeting this lethal disease. Our studies focus on identifying telomere maintenance mechanism (TMM) hallmarks adopted by CRPC to promote survival. TMMs are responsible for telomere elongation to instill replicative immortality and prevent senescence, with the two TMM pathways available being telomerase and alternative lengthening of telomeres (ALT). Here, we show that AR-independent CRPC demonstrates an atypical ALT-like phenotype with variable telomerase expression and activity, whereas AR-dependent models lack discernible ALT hallmarks. In addition, AR-independent CRPC cells exhibited elevated levels of SLX4IP, a protein implicated in promoting ALT. SLX4IP overexpression in AR-dependent C4-2B cells promoted an ALT-like phenotype and telomere maintenance. SLX4IP knockdown in AR-independent DU145 and PC-3 cells led to ALT-like hallmark reduction, telomere shortening, and induction of senescence. In PC-3 xenografts, this effect translated to reduced tumor volume. Using an in vitro model of AR-independent progression, loss of AR in AR-dependent C4-2B cells promoted an atypical ALT-like phenotype in an SLX4IP-dependent manner. Insufficient SLX4IP expression diminished ALT-like hallmarks and resulted in accelerated telomere loss and senescence.
Implications:
This study demonstrates a unique reliance of AR-independent CRPC on SLX4IP-mediated ALT-like hallmarks and loss of these hallmarks induces telomere shortening and senescence, thereby impairing replicative immortality.
Data from Loss of 9p21 Regulatory Hub Promotes Kidney Cancer Progression by Upregulating HOXB13
Authors: Baietti Maria Francesca , Zhao Peihua , Crowther Jonathan , Sewduth Raj Nayan , De Troyer Linde , Debiec-Rychter Maria , Sablina Anna A.
Published: April 2023

Abstract
Loss of chromosome 9p21 is observed in one-thirds of clear-cell renal cell carcinoma (ccRCC) and is associated with poorer patient survival. Unexpectedly, 9p21 LOH does not lead to decreased expression of the 9p21 tumor suppressor genes, CDKN2A and CDKN2B, suggesting alternative mechanisms of 9p-mediated tumorigenesis. Concordantly, CRISPR-mediated 9p21 deletion promotes growth of immortalized human embryonic kidney epithelial cells independently of the CDKN2A/B pathway inactivation. The 9p21 locus has a highly accessible chromatin structure, suggesting that 9p21 loss might contribute to kidney cancer progression by dysregulating genes distal to the 9p21 locus. We identified several 9p21 regulatory hubs by assessing which of the 9p21-interacting genes are dysregulated in 9p21-deleted kidney cells and ccRCCs. By focusing on the analysis of the homeobox gene 13 (HOXB13) locus, we found that 9p21 loss relieves the HOXB13 locus, decreasing HOXB13 methylation and promoting its expression. Upregulation of HOXB13 facilitates cell growth and is associated with poorer survival of patients with ccRCC.
Implications:
The results of our study propose a novel tumor suppressive mechanism on the basis of coordinated expression of physically associated genes, providing a better understanding of the role of chromosomal deletions in cancer.
Data from Circulating Tumor Cell Genomic Evolution and Hormone Therapy Outcomes in Men with Metastatic Castration-Resistant Prostate Cancer
Authors: Gupta Santosh , Halabi Susan , Kemeny Gabor , Anand Monika , Giannakakou Paraskevi , Nanus David M. , George Daniel J. , Gregory Simon G. , Armstrong Andrew J.
Published: April 2023

Abstract
Men with circulating tumor cell (CTC) AR-V7–positive metastatic castration-resistant prostate cancer (mCRPC) have worse outcomes when treated with enzalutamide/abiraterone. However, most men lack CTC AR-V7 detection, and additional predictive biomarkers are needed. We conducted a retrospective secondary analysis of the prospective PROPHECY trial (NCT02269982) of men with mCRPC undergoing treatment with enzalutamide/abiraterone, analyzing pooled CTC and germline DNA for whole-genome copy-number alterations (CNA) in 73 samples from 48 men over time along with pooled CTC and germline whole-exome sequencing on 22 paired samples before and following progression on androgen receptor (AR) inhibitor therapy to identify somatic genomic alterations associated with acquired resistance. We observed broad interpatient and longitudinal CTC genomic heterogeneity from AR-V7–negative men with mCRPC, including common gains of KDM6A, MYCN, and AR, and loss of ZFHX3, BRCA1, and PTEN. Men who had progression-free survival of ≤3 months despite enzalutamide/abiraterone treatment were more likely to have baseline CTC genomic loss of CHD1, PTEN, PHLPP1, and ZFHX3 and gains of BRCA2, KDM5D, MYCN, and SPARC. After progression on abiraterone/enzalutamide, we observed clonal evolution of CTCs harboring TP53 mutations and gain of ATM, KDM6A, and MYC, and loss of NCOR1, PTEN, RB1, and RUNX2. CTC genomic findings were independently confirmed in a separate cohort of mCRPC men who progressed despite prior treatment with abiraterone/enzalutamide (NCT02204943).
Implications:
We identified common and reproducible genomic alterations in CTCs from AR-V7–negative mCRPC men associated with poor outcomes during enzalutamide/abiraterone treatment, including CNAs in genes linked to lineage plasticity and epigenetic signaling, DNA repair, AR, TP53/RB1, PTEN, and WNT pathways.
Data from Genomic Landscape of Primary and Recurrent Anal Squamous Cell Carcinomas in Relation to HPV Integration, Copy-Number Variation, and DNA Damage Response Genes
Authors: Aldersley Jordan , Lorenz David R. , Mouw Kent W. , D'Andrea Alan D. , Gabuzda Dana
Published: April 2023

Abstract
The incidence of anal squamous cell carcinoma (ASCC) has been increasing, particularly in populations with HIV. Human papillomavirus (HPV) is the causal factor in 85% to 90% of ASCCs, but few studies evaluated HPV genotypes and integrations in relation to genomic alterations in ASCC. Using whole-exome sequence data for primary (n = 56) and recurrent (n = 31) ASCC from 72 patients, we detected HPV DNA in 87.5% of ASCC, of which HPV-16, HPV-18, and HPV-6 were detected in 56%, 22%, and 33% of HIV-positive (n = 9) compared with 83%, 3.2%, and 1.6% of HIV-negative cases (n = 63), respectively. Recurrent copy-number variations (CNV) involving genes with documented roles in cancer included amplification of PI3KCA and deletion of APC in primary and recurrent tumors; amplifications of CCND1, MYC, and NOTCH1 and deletions of BRCA2 and RB1 in primary tumors; and deletions of ATR, FANCD2, and FHIT in recurrent tumors. DNA damage response genes were enriched among recurrently deleted genes in recurrent ASCCs (P = 0.001). HPV integrations were detected in 29 of 76 (38%) ASCCs and were more frequent in stage III–IV versus stage I–II tumors. HPV integrations were detected near MYC and CCND1 amplifications and recurrent targets included NFI and MUC genes. These results suggest HPV genotypes in ASCC differ by HIV status, HPV integration is associated with ASCC progression, and DNA damage response genes are commonly disrupted in recurrent ASCCs.
Implications:
These data provide the largest whole-exome sequencing study of the ASCC genomic landscape to date and identify HPV genotypes, integrations, and recurrent CNVs in primary or recurrent ASCCs.
Data from Mitochondrial Aconitase ACO2 Links Iron Homeostasis with Tumorigenicity in Non–Small Cell Lung Cancer
Authors: Mirhadi Shideh , Zhang Wen , Pham Nhu-An , Karimzadeh Fereshteh , Pintilie Melania , Tong Jiefei , Taylor Paul , Krieger Jonathan , Pitcher Bethany , Sykes Jenna , Wybenga-Groot Leanne , Fladd Christopher , Xu Jing , Wang Tao , Cabanero Michael , Li Ming , Weiss Jessica , Sakashita Shingo , Zaslaver Olga , Yu Man , Caudy Amy A. , St-Pierre Julie , Hawkins Cynthia , Kislinger Thomas , Liu Geoffrey , Shepherd Frances A. , Tsao Ming-Sound , Moran Michael F.
Published: April 2023

Abstract
The ability of a patient tumor to engraft an immunodeficient mouse is the strongest known independent indicator of poor prognosis in early-stage non–small cell lung cancer (NSCLC). Analysis of primary NSCLC proteomes revealed low-level expression of mitochondrial aconitase (ACO2) in the more aggressive, engrafting tumors. Knockdown of ACO2 protein expression transformed immortalized lung epithelial cells, whereas upregulation of ACO2 in transformed NSCLC cells inhibited cell proliferation in vitro and tumor growth in vivo. High level ACO2 increased iron response element binding protein 1 (IRP1) and the intracellular labile iron pool. Impaired cellular proliferation associated with high level ACO2 was reversed by treatment of cells with an iron chelator, whereas increased cell proliferation associated with low level ACO2 was suppressed by treatment of cells with iron. Expression of CDGSH iron-sulfur (FeS) domain-containing protein 1 [CISD1; also known as mitoNEET (mNT)] was modulated by ACO2 expression level and inhibition of mNT by RNA interference or by treatment of cells with pioglitazone also increased iron and cell death. Hence, ACO2 is identified as a regulator of iron homeostasis and mNT is implicated as a target in aggressive NSCLC.
Implications:
FeS cluster–associated proteins including ACO2, mNT (encoded by CISD1), and IRP1 (encoded by ACO1) are part of an “ACO2–Iron Axis” that regulates iron homeostasis and is a determinant of a particularly aggressive subset of NSCLC.
Data from Inhibiting WEE1 and IKK-RELA Crosstalk Overcomes TNFα Resistance in Head and Neck Cancers
Authors: Hu Zhengbo , Viswanathan Ramya , Cheng Hui , Chen Jianghong , Yang Xinping , Huynh Angel , Clavijo Paul , An Yi , Robbins Yvette , Silvin Christopher , Allen Clint , Ormanoglu Pinar , Martin Scott , Cornelius Shaleeka , Saleh Anthony , Chen Zhong , Van Waes Carter , Morgan Ethan L.
Published: April 2023

Abstract
TNFα is a key mediator of immune and radiotherapy-induced cytotoxicity, but many cancers, including head and neck squamous cell carcinomas (HNSCC), display TNF resistance due to activation of the canonical IKK–NF-κB/RELA pro-survival pathway. However, toxicities associated with direct targeting of the canonical pathway point to the need to identify mechanism(s) contributing to TNFα resistance and synthetic lethal targets to overcome such resistance in cancer cells. Here, RNAi screening for modulators of TNFα–NF-κB reporter activity and cell survival unexpectedly implicated the WEE1 and CDC2 G2–M checkpoint kinases. The IKKα/β-RELA and WEE1-CDC2 signaling pathways are activated by TNFα and form a complex in cell lines derived from both human papillomavirus (−) and (+) subtypes of HNSCC. WEE1 inhibitor AZD1775 reduced IKK/RELA phosphorylation and the expression of NF-κB–dependent pro-survival proteins Cyclin D1 and BCL2. Combination of TNFα and AZD1775 enhanced caspase-mediated apoptosis in vitro, and combination treatment with radiotherapy and AZD1775 potentiated inhibition of HNSCC tumor xenograft growth in vivo, which could be significantly attenuated by TNFα depletion. These data offer new insight into the interplay between NF-κB signaling and WEE1-mediated regulation of the G2–M cell-cycle checkpoint in HNSCC.
Implications:
Inhibiting WEE1 and IKK-RELA crosstalk could potentially enhance the effects of therapies mediated by TNFα with less systemic immune suppression and toxicity than observed with direct interruption of IKK-NF-κB/RELA signaling.
Data from Distinct Transcriptional Programs in Ascitic and Solid Cancer Cells Induce Different Responses to Chemotherapy in High-Grade Serous Ovarian Cancer
Authors: Loret Nele , Vandamme Niels , De Coninck Jordy , Taminau Joachim , De Clercq Kato , Blancke Gillian , Jonckheere Sven , Goossens Steven , Lemeire Kelly , De Prijck Sofie , Verstaen Kevin , Seurinck Ruth , Van Dorpe Jo , Weyers Steven , Denys Hannelore , Van de Vijver Koen , Lambrecht Bart N. , Tummers Philippe , Saeys Yvan , Berx Geert
Published: April 2023

Abstract
High-grade serous ovarian cancer (HGSOC) is responsible for the largest number of ovarian cancer deaths. The frequent therapy-resistant relapses necessitate a better understanding of mechanisms driving therapy resistance. Therefore, we mapped more than a hundred thousand cells of HGSOC patients in different phases of the disease, using single-cell RNA sequencing. Within patients, we compared chemonaive with chemotreated samples. As such, we were able to create a single-cell atlas of different HGSOC lesions and their treatment. This revealed a high intrapatient concordance between spatially distinct metastases. In addition, we found remarkable baseline differences in transcriptomics of ascitic and solid cancer cells, resulting in a different response to chemotherapy. Moreover, we discovered different robust subtypes of cancer-associated fibroblasts (CAF) in all patients. Besides inflammatory CAFs, vascular CAFs, and matrix CAFs, we identified a new CAF subtype that was characterized by high expression of STAR, TSPAN8, and ALDH1A1 and clearly enriched after chemotherapy. Together, tumor heterogeneity in both cancer and stromal cells contributes to therapy resistance in HGSOC and could form the basis of novel therapeutic strategies that differentiate between ascitic and solid disease.
Implications:
The newly characterized differences between ascitic and solid cancer cells before and after chemotherapy could inform novel treatment strategies for metastatic HGSOC.
Data from Constitutive β-Catenin Overexpression Represses Lncrna MIR100HG Transcription via HDAC6-Mediated Histone Modification in Colorectal Cancer
Authors: Peng Jian , Ma Yiming , Zhao Xinhua , Yang Xu , Wang Hongying
Published: April 2023

Abstract
Wnt/β-catenin signaling plays a critical role in colonic carcinogenesis. However, non-coding RNAs (ncRNA) transcriptionally regulated by β-catenin are largely unknown. Herein, we found that lncRNA MIR100HG (lnc-MIR100HG) negatively correlated with target genes of β-catenin from The Cancer Genome Atlas colorectal carcinoma database, which was verified in 48 paired colorectal carcinoma specimens. In addition, constitutive overexpression of β-catenin decreased primary and mature lnc-MIR100HG levels, whereas blockage of β-catenin activity with siRNA or inhibitors significantly increased their expression. DNA pull-down and chromatin immunoprecipitation revealed the binding of β-catenin/TCF4 to the MIR100HG promoter. Moreover, β-catenin–forced expression reduced the enrichment of H3K27Ac, an active transcription marker, on the promoter, whereas β-catenin inhibition reversed this effect. Furthermore, HDAC6 was recruited to the MIR100HG promoter and downregulated H3K27Ac enrichment in a β-catenin–dependent manner. Besides, HDAC6 was upregulated and negatively correlated with lnc-MIR100HG in colorectal carcinoma specimens. Functional studies showed that lnc-MIR100HG overexpression induced cell-cycle G0–G1 arrest and repressed cell proliferation via p57 upregulation in vitro and in vivo. Taken together, we found that ectopic β-catenin transcriptionally repressed lnc-MIR100HG expression through HDAC6-mediated histone modification in colorectal carcinoma. Lnc-MIR100HG regulates the cell cycle through p57.
Implications:
It provides a novel downstream mechanism highlighting β-catenin action during colon carcinogenesis and may shed light for further therapeutic approaches.
Data from Targeting Metabolic Adaptations in the Breast Cancer–Liver Metastatic Niche Using Dietary Approaches to Improve Endocrine Therapy Efficacy
Authors: Zuo Qianying , Mogol Ayca Nazli , Liu Yu-Jeh , Santaliz Casiano Ashlie , Chien Christine , Drnevich Jenny , Imir Ozan Berk , Kulkoyluoglu-Cotul Eylem , Park Nicole Hwajin , Shapiro David J. , Park Ben Ho , Ziegler Yvonne , Katzenellenbogen Benita S. , Aranda Evelyn , O'Neill John D. , Raghavendra Akshara Singareeka , Tripathy Debu , Madak Erdogan Zeynep
Published: April 2023

Abstract
Estrogen receptor–positive (ER+) metastatic tumors contribute to nearly 70% of breast cancer–related deaths. Most patients with ER+ metastatic breast cancer (MBC) undergo treatment with the estrogen receptor antagonist fulvestrant as standard of care. Yet, among such patients, metastasis in liver is associated with reduced overall survival compared with other metastasis sites. The factors underlying the reduced responsiveness of liver metastases to ER-targeting agents remain unknown, impeding the development of more effective treatment approaches to improve outcomes for patients with ER+ liver metastases. We therefore evaluated site-specific changes in MBC cells and determined the mechanisms through which the liver metastatic niche specifically influences ER+ tumor metabolism and drug resistance. We characterized ER activity of MBC cells both in vitro, using a novel system of tissue-specific extracellular matrix hydrogels representing the stroma of ER+ tumor metastatic sites (liver, lung, and bone), and in vivo, in liver and lung metastasis mouse models. ER+ metastatic liver tumors and MBC cells grown in liver hydrogels displayed upregulated expression of glucose metabolism enzymes in response to fulvestrant. Furthermore, differential ER± activity, but not expression, was detected in liver hydrogels. In vivo, increased glucose metabolism led to increased glycogen deposition in liver metastatic tumors, while a fasting-mimicking diet increased efficacy of fulvestrant treatment to reduce the metastatic burden. Our findings identify a novel mechanism of endocrine resistance driven by the liver tumor microenvironment.
Implications:
These results may guide the development of dietary strategies to circumvent drug resistance in liver metastasis, with potential applicability in other metastatic diseases.

Watch the interview with Zeynep Madak-Erdogan, PhD, recipient of the 2024 MCR Michael B. Kastan Award for Research Excellence: https://vimeo.com/992993791
Data from Sohlh2 Regulates the Stemness and Differentiation of Colon Cancer Stem Cells by Downregulating LncRNA-H19 Transcription
Authors: Zhang Ruihong , Zhang Xiaoli , Zhang Wenfang , Cui Weiwei , Xiao Yunling , Liu Lanlan , Zhi Sujuan , Feng Xiaoning , Liu Xuyue , Shen Ying , Chai Jie , Hao Jing
Published: April 2023

Abstract
Colon cancer stem cells (CSC) are tumor-initiating cells that drive tumorigenesis and progression through self-renewal and various differentiation potency. Therefore, the identification of factors critical for colon CSC function is vital for the development of therapies. Sohlh2 belongs to the superfamily of bhlh transcription factors and serves as a tumor suppressor in several tumors. The role of Sohlh2 in CSCs remains unknown. Here we demonstrated that Sohlh2 was related to the inhibition of LncRNA-H19/miR-141/β-catenin signaling and led to the consequent suppression of colon CSC stemness and the promotion of colon CSC differentiation in vitro and in vivo. Moreover, Sohlh2 could directly bind to the promoter of LncRNA-H19 and repress its transcription activity. LncRNA-H19 mediated the effects of Sohlh2 on colon CSC stemness and differentiation. Clinically, we observed a significant inverse correlation between Sohlh2 and LncRNA-H19, β-catenin, Lgr5, CD133 expression levels, and positive correlation between Sohlh2 and MUC2, TFF2 expression in colon cancer tissues. Collectively, our findings suggest an important role of the Sohlh2/LncRNA-H19/miR-141/β-catenin pathway in regulating colon CSC stemness and differentiation, suggesting potential therapeutic targets for colon cancer.
Implications:
This study identifies that Sohlh2 directly manipulates LncRNA-H19 transcription and suppresses the β-catenin signaling pathway and the Sohlh2/LncRNA-H19/miR-141/β-catenin signaling pathway plays an essential role in the stemness of colon CSCs.
Related Article from Genetic Driver Events in Premalignancy: LOH Validated for Marking the Risk of Oral Cancer
Authors: Cavenee Webster K.
Published: April 2023

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Perspective on this Article from NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase Regulates Levels of Bioactive Lipids in Non–Small Cell Lung Cancer
Authors: Hughes Duncan , Otani Taisuke , Yang Peiying , Newman Robert A. , Yantiss Rhonda K. , Altorki Nasser K. , Port Jeff L. , Yan Min , Markowitz Sanford D. , Mazumdar Madhu , Tai Hsin-Hsiung , Subbaramaiah Kotha , Dannenberg Andrew J.
Published: April 2023

Perspective on this Article from NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase Regulates Levels of Bioactive Lipids in Non–Small Cell Lung Cancer
Perspective from Aberrant Crypt Foci in the Adenoma Prevention with Celecoxib Trial
Authors: Cho Nancy L. , Redston Mark , Zauber Ann G. , Carothers Adelaide M. , Hornick Jason , Wilton Andrew , Sontag Stephen , Nishioka Norman , Giardiello Francis M. , Saltzman John R. , Gostout Chris , Eagle Craig J. , Hawk Ernest T. , Bertagnolli Monica M.
Published: April 2023

Perspective from Aberrant Crypt Foci in the Adenoma Prevention with Celecoxib Trial
Perspective on this Article from Sunitinib Prolongs Survival in Genetically Engineered Mouse Models of Multistep Lung Carcinogenesis
Authors: Gandhi Leena , McNamara Kate L. , Li Danan , Borgman Christa L. , McDermott Ultan , Brandstetter Kathleyn A. , Padera Robert F. , Chirieac Lucian R. , Settleman Jeffrey E. , Wong Kwok-Kin
Published: April 2023

Perspective on this Article from Sunitinib Prolongs Survival in Genetically Engineered Mouse Models of Multistep Lung Carcinogenesis
Perspective on this Article from Risk of Cardiovascular Events in a Randomized Placebo-Controlled, Double-Blind Trial of Difluoromethylornithine plus Sulindac for the Prevention of Sporadic Colorectal Adenomas
Authors: Zell Jason A. , Pelot Daniel , Chen Wen-Pin , McLaren Christine E. , Gerner Eugene W. , Meyskens Frank L.
Published: April 2023

Perspective on this Article from Risk of Cardiovascular Events in a Randomized Placebo-Controlled, Double-Blind Trial of Difluoromethylornithine plus Sulindac for the Prevention of Sporadic Colorectal Adenomas
Supplementary Figure 1 from Failure Rates in the Hepatocellular Carcinoma Surveillance Process
Authors: Singal Amit G. , Yopp Adam C. , Gupta Samir , Skinner Celette Sugg , Halm Ethan A. , Okolo Eucharia , Nehra Mahendra , Lee William M. , Marrero Jorge A. , Tiro Jasmin A.
Published: April 2023

PDF file, 64K, Study Population.
Related Articles from The Promise of Natural Products for Blocking Early Events in Skin Carcinogenesis
Authors: Clifford John L. , DiGiovanni John
Published: April 2023

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Related Article from Chemoprevention of Pancreatic Cancer: Ready for the Clinic?
Authors: Logsdon Craig D. , Abbruzzese James L.
Published: April 2023

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Related Article from Genetic Variation in 3-Hydroxy-3-Methylglutaryl CoA Reductase Modifies the Chemopreventive Activity of Statins for Colorectal Cancer
Authors: Lipkin Steven M. , Chao Elizabeth C. , Moreno Victor , Rozek Laura S. , Rennert Hedy , Pinchev Mila , Dizon Diana , Rennert Gad , Kopelovich Levy , Gruber Stephen B.
Published: April 2023

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Supplementary Table 8 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq
Authors: Beane Jennifer , Vick Jessica , Schembri Frank , Anderlind Christina , Gower Adam , Campbell Joshua , Luo Lingqi , Zhang Xiao Hui , Xiao Ji , Alekseyev Yuriy O. , Wang Shenglong , Levy Shawn , Massion Pierre P. , Lenburg Marc , Spira Avrum
Published: April 2023

Supplementary Table 8 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq
Supplementary Figure 1 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq
Authors: Beane Jennifer , Vick Jessica , Schembri Frank , Anderlind Christina , Gower Adam , Campbell Joshua , Luo Lingqi , Zhang Xiao Hui , Xiao Ji , Alekseyev Yuriy O. , Wang Shenglong , Levy Shawn , Massion Pierre P. , Lenburg Marc , Spira Avrum
Published: April 2023

Supplementary Figure 1 from Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq
Supplementary Table S3 from Constitutional Methylation of the BRCA1 Promoter Is Specifically Associated with BRCA1 Mutation-Associated Pathology in Early-Onset Breast Cancer
Authors: Wong Ee Ming , Southey Melissa C. , Fox Stephen B. , Brown Melissa A. , Dowty James G. , Jenkins Mark A. , Giles Graham G. , Hopper John L. , Dobrovic Alexander
Published: April 2023

Supplementary Table S3 from Constitutional Methylation of the BRCA1 Promoter Is Specifically Associated with BRCA1 Mutation-Associated Pathology in Early-Onset Breast Cancer
Supplementary Table 1 from Lactobacillus Salivarius REN Inhibits Rat Oral Cancer Induced by 4-Nitroquioline 1-Oxide
Authors: Zhang Ming , Wang Fang , Jiang Lu , Liu Ruihai , Zhang Lian , Lei Xingen , Li Jiyou , Jiang Jingli , Guo Huiyuan , Fang Bing , Zhao Liang , Ren Fazheng
Published: April 2023

PDF file - 119K, Body, liver, relative liver, kidney, relative kidney weights in each group.
Perspective on This Article from Bexarotene Plus Erlotinib Suppress Lung Carcinogenesis Independent of KRAS Mutations in Two Clinical Trials and Transgenic Models
Authors: Dragnev Konstantin H. , Ma Tian , Cyrus Jobin , Galimberti Fabrizio , Memoli Vincent , Busch Alexander M. , Tsongalis Gregory J. , Seltzer Marc , Johnstone David , Erkmen Cherie P. , Nugent William , Rigas James R. , Liu Xi , Freemantle Sarah J. , Kurie Jonathan M. , Waxman Samuel , Dmitrovsky Ethan
Published: April 2023

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Perspective on This Article from p16INK4a Expression and Breast Cancer Risk in Women with Atypical Hyperplasia
Authors: Radisky Derek C. , Santisteban Marta , Berman Hal K. , Gauthier Mona L. , Frost Marlene H. , Reynolds Carol A. , Vierkant Robert A. , Pankratz V. Shane , Visscher Daniel W. , Tlsty Thea D. , Hartmann Lynn C.
Published: April 2023

Perspective on This Article from p16INK4a Expression and Breast Cancer Risk in Women with Atypical Hyperplasia
Supplementary Table 5 from Molecular Profiling of Premalignant Lesions in Lung Squamous Cell Carcinomas Identifies Mechanisms Involved in Stepwise Carcinogenesis
Authors: Ooi Aik T. , Gower Adam C. , Zhang Kelvin X. , Vick Jessica L. , Hong Longsheng , Nagao Brian , Wallace W. Dean , Elashoff David A. , Walser Tonya C. , Dubinett Steven M. , Pellegrini Matteo , Lenburg Marc E. , Spira Avrum , Gomperts Brigitte N.
Published: April 2023

XLS file - 32KB, MYC activity prediction and its target genes.
Supplementary Table 3 from Molecular Profiling of Premalignant Lesions in Lung Squamous Cell Carcinomas Identifies Mechanisms Involved in Stepwise Carcinogenesis
Authors: Ooi Aik T. , Gower Adam C. , Zhang Kelvin X. , Vick Jessica L. , Hong Longsheng , Nagao Brian , Wallace W. Dean , Elashoff David A. , Walser Tonya C. , Dubinett Steven M. , Pellegrini Matteo , Lenburg Marc E. , Spira Avrum , Gomperts Brigitte N.
Published: April 2023

XLSX file - 343KB, Genes associated with SCC carcinogenesis.
Supplementary Table 3 from Prevention of Colitis-Associated Colorectal Cancer with 8-Hydroxydeoxyguanosine
Authors: Ock Chan Young , Kim Eun-Hee , Hong Hua , Hong Kyung Sook , Han Young-Min , Choi Ki-Seok , Hahm Ki-Baik , Chung Myung-Hee
Published: April 2023

PDF file - 108K
Supplementary Table 1 from Prevention of Colitis-Associated Colorectal Cancer with 8-Hydroxydeoxyguanosine
Authors: Ock Chan Young , Kim Eun-Hee , Hong Hua , Hong Kyung Sook , Han Young-Min , Choi Ki-Seok , Hahm Ki-Baik , Chung Myung-Hee
Published: April 2023

PDF file - 53K
Perspective on this Article from A Large Prospective Study of SEP15 Genetic Variation, Interaction with Plasma Selenium Levels, and Prostate Cancer Risk and Survival
Authors: Penney Kathryn L. , Schumacher Fredrick R. , Li Haojie , Kraft Peter , Morris J. Steven , Kurth Tobias , Mucci Lorelei A. , Hunter David J. , Kantoff Philip W. , Stampfer Meir J. , Ma Jing
Published: April 2023

Perspective on this Article from A Large Prospective Study of SEP15 Genetic Variation, Interaction with Plasma Selenium Levels, and Prostate Cancer Risk and Survival
Supplementary Materials from Targeting FACT Complex Suppresses Mammary Tumorigenesis in Her2/neu Transgenic Mice
Authors: Koman Igor E. , Commane Mairead , Paszkiewicz Geraldine , Hoonjan Bhupinder , Pal Srabani , Safina Alfiya , Toshkov Ilya , Purmal Andrei A. , Wang Dan , Liu Song , Morrison Carl , Gudkov Andrei V. , Gurova Katerina V.
Published: April 2023

PDF file - 11K, List of antibodies used in the study
Supplementary Figure Legends from Effects of Metformin, Buformin, and Phenformin on the Post-Initiation Stage of Chemically Induced Mammary Carcinogenesis in the Rat
Authors: Zhu Zongjian , Jiang Weiqin , Thompson Matthew D. , Echeverria Dimas , McGinley John N. , Thompson Henry J.
Published: April 2023

Supplementary Figure Legends. Supplementary Figure Legends
Supplementary Figures 1-3 from Celecoxib Inhibits Interleukin-6/Interleukin-6 Receptor–Induced JAK2/STAT3 Phosphorylation in Human Hepatocellular Carcinoma Cells
Authors: Liu Yan , Liu Aiguo , Li Huameng , Li Chenglong , Lin Jiayuh
Published: April 2023

PDF file - 217K
Supplementary Table 1 from Serum Glycan Signatures of Gastric Cancer
Authors: Ozcan Sureyya , Barkauskas Donald A. , Renee Ruhaak L. , Torres Javier , Cooke Cara L. , An Hyun Joo , Hua Serenus , Williams Cynthia C. , Dimapasoc Lauren M. , Han Kim Jae , Camorlinga-Ponce Margarita , Rocke David , Lebrilla Carlito B. , Solnick Jay V.
Published: April 2023

PDF file - 57K, Glycans detected in serum samples.
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Supplementary Figures 1-4 from Metformin Prevents the Development of Oral Squamous Cell Carcinomas from Carcinogen-Induced Premalignant Lesions
Authors: Vitale-Cross Lynn , Molinolo Alfredo A. , Martin Daniel , Younis Rania H. , Maruyama Takashi , Patel Vyomesh , Chen Wanjun , Schneider Abraham , Gutkind J. Silvio
Published: April 2023

PDF file - 92K
Supplementary Data from Chemoprevention of Lung Squamous Cell Carcinoma in Mice by a Mixture of Chinese Herbs
Authors: Wang Yian , Zhang Zhongqiu , Garbow Joel R. , Rowland Doug J. , Lubet Ronald A. , Sit Daniel , Law Francis , You Ming
Published: April 2023

Supplementary Data from Chemoprevention of Lung Squamous Cell Carcinoma in Mice by a Mixture of Chinese Herbs
Supplementary Figure 2 from Global Reactivation of Epigenetically Silenced Genes in Prostate Cancer
Authors: Ibragimova Ilsiya , Ibáñez de Cáceres Inmaculada , Hoffman Amanda M. , Potapova Anna , Dulaimi Essel , Al-Saleem Tahseen , Hudes Gary R. , Ochs Michael F. , Cairns Paul
Published: April 2023

Supplementary Figure 2 from Global Reactivation of Epigenetically Silenced Genes in Prostate Cancer
Perspective on This Article from Global Reactivation of Epigenetically Silenced Genes in Prostate Cancer
Authors: Ibragimova Ilsiya , Ibáñez de Cáceres Inmaculada , Hoffman Amanda M. , Potapova Anna , Dulaimi Essel , Al-Saleem Tahseen , Hudes Gary R. , Ochs Michael F. , Cairns Paul
Published: April 2023

Perspective on This Article from Global Reactivation of Epigenetically Silenced Genes in Prostate Cancer
Supplementary Materials and Methods from Folate Deficiency Induces Dysfunctional Long and Short Telomeres; Both States Are Associated with Hypomethylation and DNA Damage in Human WIL2-NS Cells
Authors: Bull Caroline F. , Mayrhofer Graham , O'Callaghan Nathan J. , Au Amy Y. , Pickett Hilda A. , Low Grace Kah Mun , Zeegers Dimphy , Hande M. Prakash , Fenech Michael F.
Published: April 2023

PDF file 146K, Materials and Methods additional to those described in the main article
Supplementary Methods from Inositol Hexaphosphate Inhibits Tumor Growth, Vascularity, and Metabolism in TRAMP Mice: A Multiparametric Magnetic Resonance Study
Authors: Raina Komal , Ravichandran Kameswaran , Rajamanickam Subapriya , Huber Kendra M. , Serkova Natalie J. , Agarwal Rajesh
Published: April 2023

PDF file - 84K
Supplementary Figure 1 from Inositol Hexaphosphate Inhibits Tumor Growth, Vascularity, and Metabolism in TRAMP Mice: A Multiparametric Magnetic Resonance Study
Authors: Raina Komal , Ravichandran Kameswaran , Rajamanickam Subapriya , Huber Kendra M. , Serkova Natalie J. , Agarwal Rajesh
Published: April 2023

PDF file - 52K, Dose dependent effect of IP6 feeding on, (A) proliferation (PCNA staining); (B) apoptosis (TUNEL assay); (C) intraductal microvessel density (PECAM-1/CD-31 staining) in dorsolateral prostate of TRAMP mice. Quantification of positive cells is shown as mean and � SEM (error bars) in each group.
Supplementary Figure 4 from Cortactin and Focal Adhesion Kinase as Predictors of Cancer Risk in Patients with Laryngeal Premalignancy
Authors: Rodrigo Juan P. , Álvarez-Alija Gustavo , Menéndez Sofía Tirados , Mancebo Gonzalo , Allonca Eva , García-Carracedo Darío , Fresno Manuel Florentino , Suárez Carlos , García-Pedrero Juana María
Published: April 2023

PDF file - 153K
Supplementary Methods, Figure Legends, Tables 1 - 2 from Slow Overmethylation of Housekeeping Genes in the Body Mucosa Is Associated with the Risk for Gastric Cancer
Authors: Oh Jung-Hwan , Rhyu Mun-Gan , Jung Sung-Hoon , Choi Sang-Wook , Kim Suk-Il , Hong Seung-Jin
Published: April 2023

PDF file - 259KB, Supplementary Table S1. Summary of the 19 genes selected for analysis of transitional-CpG methylation. Supplementary Table S2. Comparison of overmethylation frequencies detected in the H. pylori-positive and H. pylori-negative gastric cancer patients.
Supplementary Table 2 from Alcohol Consumption Promotes Diethylnitrosamine-Induced Hepatocarcinogenesis in Male Mice through Activation of the Wnt/β-Catenin Signaling Pathway
Authors: Mercer Kelly E. , Hennings Leah , Sharma Neha , Lai Keith , Cleves Mario A. , Wynne Rebecca A. , Badger Thomas M. , Ronis Martin J.J.
Published: April 2023

PDF file - 86K, Results from the WNT signaling pathway RT2 profiler PCR array between TEN+EtOH and TEN control livers.
Supplementary Figure-5 from Novel Evidence for Curcumin and Boswellic Acid–Induced Chemoprevention through Regulation of miR-34a and miR-27a in Colorectal Cancer
Authors: Toden Shusuke , Okugawa Yoshinaga , Buhrmann Constanze , Nattamai Durgha , Anguiano Esperanza , Baldwin Nicole , Shakibaei Mehdi , Boland C. Richard , Goel Ajay
Published: April 2023

Supplementary Figure-5. Curcumin and AKBA modulate genes involved in cell cycle regulation.
Supplementary Figure-1 from Novel Evidence for Curcumin and Boswellic Acid–Induced Chemoprevention through Regulation of miR-34a and miR-27a in Colorectal Cancer
Authors: Toden Shusuke , Okugawa Yoshinaga , Buhrmann Constanze , Nattamai Durgha , Anguiano Esperanza , Baldwin Nicole , Shakibaei Mehdi , Boland C. Richard , Goel Ajay
Published: April 2023

Supplementary Figure-1. Inhibitory concentration 50 of curcumin and AKBA.
Supplementary Figure 3 from Divergent Roles of PAX2 in the Etiology and Progression of Ovarian Cancer
Authors: Al-Hujaily Ensaf M. , Tang Yong , Yao De-Sheng , Carmona Euridice , Garson Kenneth , Vanderhyden Barbara C.
Published: April 2023

Expression of PAX2 in p53-null cells enhanced proliferation but not survival.
Supplementary Figure 8 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of Igf1r That Persists Long after Parturition
Authors: Katz Tiffany A. , Liao Serena G. , Palmieri Vincent J. , Dearth Robert K. , Pathiraja Thushangi N. , Huo Zhiguang , Shaw Patricia , Small Sarah , Davidson Nancy E. , Peters David G. , Tseng George C. , Oesterreich Steffi , Lee Adrian V.
Published: April 2023

Supplemental Fig S8. Hypermethylation of the Igf1r aligns with sites of histone methylation. (A) The UCSC Genome Browser was used to align the Igf1r with other epigenetic modifications. The red bar indicates the region of differential DNA methylation identified in the SureSelectXT Methyl-Seq Assay. Black bars represent sites of histone methylation, the intensity corresponds to the degree of methylation. (B) Igf1r bisulfite sequencing data are depicted. Each animal is numbered and each horizontal line represents DNA from a separate clone from that animal. The percent methylation of each animal is listed under each CpG site. Open circles = unmethylated, and closed circles = methylated. The lower panel represents a combined result from all clones in all animals.
Supplementary Figure 3 from Hepatitis B Virus Combo Mutations Improve the Prediction and Active Prophylaxis of Hepatocellular Carcinoma: A Clinic-Based Cohort Study
Authors: Yin Jianhua , Wang Junxue , Pu Rui , Xin Haiguang , Li Zixiong , Han Xue , Ding Yibo , Du Yan , Liu Wenbin , Deng Yang , Ji Xiaowei , Wu Ming , Yu Min , Zhang Hongwei , Wang Hongyang , Thompson Timothy C. , Ni Wu , Cao Guangwen
Published: April 2023

Supplementary Figure 3. Effect of antiviral treatment on liver death of chronic HBV-infected patients with and without the significant viral mutation in the PS matched cohorts. (A) patients with A1762T/G1764A; (B) patients without A1762T/G1764A; (C) patients with C1653T; (D) patients without C1653T; (E) patients with T1753V; (F) patients without T1753V. P values, log-rank test.
Supplemental Table 5 from Notch1 Mutations Are Drivers of Oral Tumorigenesis
Authors: Izumchenko Evgeny , Sun Kai , Jones Sian , Brait Mariana , Agrawal Nishant , Koch Wayne , McCord Christine L. , Riley David R. , Angiuoli Samuel V. , Velculescu Victor E. , Jiang Wei-Wen , Sidransky David
Published: April 2023

Supplemental Table 5. List of 108 primer pairs designed by Fluidigm Assay Design Group and used in this study for NOTCH1 amplification. Table summarizes the GC-content, length distribution and location of the Access Array amplicons.
Supplemental figure 5 from Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate
Authors: Cho Jiyoon , Rho Okkyung , Junco Jacob , Carbajal Steve , Siegel Dionicio , Slaga Thomas J. , DiGiovanni John
Published: April 2023

Effect of UA + Res on DNA binding activity and nuclear translocation of NF-κB, Egr-1, and AP-1 induced by TPA.
Supplementary Materials and Methods from St. John's Wort Attenuates Colorectal Carcinogenesis in Mice through Suppression of Inflammatory Signaling
Authors: Manna Soumen K. , Golla Srujana , Golla Jaya Prakash , Tanaka Naoki , Cai Yan , Takahashi Shogo , Krausz Kristopher W. , Matsubara Tsutomu , Korboukh Ilia , Gonzalez Frank J.
Published: April 2023

Extraction of constituents from the SJW Diet and SJW Powder UPLC-MS Analysis
Supplementary Table 1. from Serum Glycans as Risk Markers for Non–Small Cell Lung Cancer
Authors: Ruhaak L. Renee , Stroble Carol , Dai Jianliang , Barnett Matt , Taguchi Ayumu , Goodman Gary E. , Miyamoto Suzanne , Gandara David , Feng Ziding , Lebrilla Carlito B. , Hanash Samir
Published: April 2023

Formulas used to calculate glycan feature data.
Related Articles from Alu in Lynch Syndrome: A Danger SINE?
Authors: Hitchins Megan P. , Burn John
Published: April 2023

Related Articles from Alu in Lynch Syndrome: A Danger SINE?
Supplementary Table S2 from Enhanced Antitumor Effects of Novel Intracellular Delivery of an Active Form of Menaquinone-4, Menahydroquinone-4, into Hepatocellular Carcinoma
Authors: Setoguchi Shuichi , Watase Daisuke , Matsunaga Kazuhisa , Matsubara Misa , Kubo Yohei , Kusuda Mariko , Nagata-Akaho Nami , Enjoji Munechika , Nakashima Manabu , Takeshita Morishige , Karube Yoshiharu , Takata Jiro
Published: April 2023

Supplementary Table S2. Pharmacokinetic parameters of MKH-DMG and MK-4 in plasma and liver after p.o. administration of MKH-DMG in mice.
Suppl. Table 1 from Voluntary Wheel Running Reduces the Acute Inflammatory Response to Liver Carcinogen in a Sex-specific Manner
Authors: Bay M.L. , Gehl Julie , Pedersen Bente Klarlund , Hojman Pernille
Published: April 2023

Supplementary Table 1. Primer sequences, slope and R2 for qPCR std. curves.
Supplement1 from Fallopian Tube Lesions in Women at High Risk for Ovarian Cancer: A Multicenter Study
Authors: Visvanathan Kala , Shaw Patricia , May Betty J. , Bahadirli-Talbott Asli , Kaushiva Alpana , Risch Harvey , Narod Steven , Wang Tian-Li , Parkash Vinita , Vang Russell , Levine Douglas A. , Soslow Robert , Kurman Robert , Shih Ie-Ming
Published: April 2023

Supplement 1. Diagram describing the approach used for sampling of tissue blocks in Part 2 and Part 3 of the study.
Supplementary Figures and Tables from Randomized Phase IIB Trial of the Lignan Secoisolariciresinol Diglucoside in Premenopausal Women at Increased Risk for Development of Breast Cancer
Authors: Fabian Carol J. , Khan Seema A. , Garber Judy E. , Dooley William C. , Yee Lisa D. , Klemp Jennifer R. , Nydegger Jennifer L. , Powers Kandy R. , Kreutzjans Amy L. , Zalles Carola M. , Metheny Trina , Phillips Teresa A. , Hu Jinxiang , Koestler Devin C. , Chalise Prabhakar , Yellapu Nanda Kumar , Jernigan Cheryl , Petroff Brian K. , Hursting Stephen D. , Kimler Bruce F.
Published: April 2023

Supplementary Figures and Tables
Figure S5 from Prevention of Tobacco Carcinogen-Induced Lung Tumor Development by a Novel STAT3 Decoy Inhibitor
Authors: Njatcha Christian , Farooqui Mariya , Almotlak Abdulaziz A. , Siegfried Jill M.
Published: April 2023

Supplementary Figure 5
Supplemental tables and figure legends from Persistence of Bronchial Dysplasia Is Associated with Development of Invasive Squamous Cell Carcinoma
Authors: Merrick Daniel T. , Gao Dexiang , Miller York E. , Keith Robert L. , Baron Anna E. , Feser William , Kennedy Timothy C. , Blatchford Patrick J. , Braudrick Sarah , Hirsch Fred R. , Heasley Lynn , Bunn Paul A. , Franklin Wilbur A.
Published: April 2023

SUPPLEMENTAL TABLE S1. BIOPSY AND CLINCAL CHARACTERISTICS. SUPPLEMENTAL TABLE S2. BASELINE HISTOLOGY AND OUTCOME.
Supplementary Table Legend from A Randomized Phase II Trial of Pioglitazone for Lung Cancer Chemoprevention in High-Risk Current and Former Smokers
Authors: Keith Robert L. , Blatchford Patrick J. , Merrick Daniel T. , Bunn Paul A. , Bagwell Brandi , Dwyer-Nield Lori D. , Jackson Mary K. , Geraci Mark W. , Miller York E.
Published: April 2023

Legends for Supplementary Tables 1 and 2
Supplemental Table 1 from Obesity is Associated with Shorter Telomere Length in Prostate Stromal Cells in Men with Aggressive Prostate Cancer
Authors: Joshu Corinne E. , Heaphy Christopher M. , Barber John R. , Lu Jiayun , Zarinshenas Reza , Davis Christine , Han Misop , Lotan Tamara L. , Sfanos Karen S. , De Marzo Angelo M. , Meeker Alan K. , Platz Elizabeth A.
Published: April 2023

Odds ratios (OR) and 95% confidence intervals (CI) for the association between body mass index (BMI) category and telomere variability* in prostate cancer cells overall and stratified by prostate cancer aggressiveness at surgery among men surgically treated for prostate cancer at Johns Hopkins Hospital, 1992 to 2016.
Supplementary Table 1 from Comparison of Effects of Diet on Mammary Cancer: Efficacy of Various Preventive Agents and Metabolomic Changes of Different Diets and Agents
Authors: Lubet Ronald A. , Beger Richard D. , Miller Mark Steven , Luster John , Seifried Harold E. , Grubbs Clinton J.
Published: April 2023

Biomarker 78DOA 190 DOA
Supplementary Table 1 from Evaluating the Utility and Prevalence of HPV Biomarkers in Oral Rinses and Serology for HPV-related Oropharyngeal Cancer
Authors: D'Souza Gypsyamber , Clemens Gwendolyn , Troy Tanya , Castillo Rachel G. , Struijk Linda , Waterboer Tim , Bender Noemi , Pierorazio Phillip M. , Best Simon R. , Strickler Howard , Wiley Dorothy J. , Haddad Robert I. , Posner Marshall , Fakhry Carole
Published: April 2023

Supplementary Table 1
Supplementary Table 3 from Methyl Donor Deficiency Blocks Colorectal Cancer Development by Affecting Key Metabolic Pathways
Authors: Hanley Matthew P. , Aladelokun Oladimeji , Kadaveru Krishna , Rosenberg Daniel W.
Published: April 2023

Analysis of correlations between individual metabolites and immunohistochemical markers of proliferation, apoptosis, and colonic stem cells.
Table S5 from Uptake and Predictors of Opportunistic Salpingectomy for Ovarian Cancer Risk Reduction in the United States
Authors: Karia Pritesh S. , Joshu Corinne E. , Visvanathan Kala
Published: April 2023

This table shows the results of the multivariable-adjusted analysis of factors associated with hysterectomy and OS use before and after the release of the clinical practice guideline.
Supplementary Tables from Specificity of the Multi-Target Stool DNA Test for Colorectal Cancer Screening in Average-Risk 45–49 Year-Olds: A Cross-Sectional Study
Authors: Imperiale Thomas F. , Kisiel John B. , Itzkowitz Steven H. , Scheu Bradley , Duimstra Emma Kate , Statz Sandra , Berger Barry M. , Limburg Paul J.
Published: April 2023

Supplementary Tables
Supplementary Figure from Treatment Strategies and Mechanisms Associated with the Prevention of NASH-Associated HCC by a Toll-like Receptor 4 Inhibitor
Authors: Kwan Suet-Ying , Slayden Alyssa N. , Coronado Aubrey R. , Marquez Rosamaria C. , Chen Huiqin , Wei Peng , Savage Michelle I. , Vornik Lana A. , Fox Jennifer T. , Sei Shizuko , Liang Dong , Stevenson Heather L. , Wilkerson Gregory K. , Gagea Mihai , Brown Powel H. , Beretta Laura
Published: April 2023

Supplementary Figure from Treatment Strategies and Mechanisms Associated with the Prevention of NASH-Associated HCC by a Toll-like Receptor 4 Inhibitor
Table S4 from Post Genome-Wide Gene–Environment Interaction Study Using Random Survival Forest: Insulin Resistance, Lifestyle Factors, and Colorectal Cancer Risk
Authors: Jung Su Yon , Papp Jeanette C. , Sobel Eric M. , Zhang Zuo-Feng
Published: April 2023

multivariate regression by PA or SFA
Supplementary Table from Variant Identification in BARD1, PRDM9, RCC1, and RECQL in Patients with Ovarian Cancer by Targeted Next-generation Sequencing of DNA Pools
Authors: Suszynska Malwina , Ratajska Magdalena , Galka-Marciniak Paulina , Ryszkowska Aleksandra , Wydra Dariusz , Debniak Jaroslaw , Jasiak Anna , Wasag Bartosz , Cybulski Cezary , Kozlowski Piotr
Published: April 2023

Supplementary Table from Variant Identification in BARD1, PRDM9, RCC1, and RECQL in Patients with Ovarian Cancer by Targeted Next-generation Sequencing of DNA Pools
Supplementary Table 2 legend from Gene Signature in Sessile Serrated Polyps Identifies Colon Cancer Subtype
Authors: Kanth Priyanka , Bronner Mary P. , Boucher Kenneth M. , Burt Randall W. , Neklason Deborah W. , Hagedorn Curt H. , Delker Don A.
Published: April 2023

Suppl Table 2 legend
Supplemental Figures from A BET Bromodomain Inhibitor Suppresses Adiposity-Associated Malignant Transformation
Authors: Chakraborty Debrup , Benham Vanessa , Jdanov Vladislav , Bullard Blair , Leal Ana S. , Liby Karen T. , Bernard Jamie J.
Published: April 2023

Supplemental Figures 1-3
Fig-S3 from Mitotic Spindle Apparatus Abnormalities in Chronic Obstructive Pulmonary Disease Cells: A Potential Pathway to Lung Cancer
Authors: Thaiparambil Jose , Dong Lingyun , Jasso Diana , Huang Jian-An , El-Zein Randa A.
Published: April 2023

Folds change of genes expression
Supplementary Table 1 from HIST1H2BB and MAGI2 Methylation and Somatic Mutations as Precision Medicine Biomarkers for Diagnosis and Prognosis of High-grade Serous Ovarian Cancer
Authors: Valle Blanca L. , Rodriguez-Torres Sebastian , Kuhn Elisabetta , Díaz-Montes Teresa , Parrilla-Castellar Edgardo , Lawson Fahcina P. , Folawiyo Oluwasina , Ili-Gangas Carmen , Brebi-Mieville Priscilla , Eshleman James R. , Herman James , Shih Ie-Ming , Sidransky David , Guerrero-Preston Rafael
Published: April 2023

Survival Genes