bluuebunny/crossref_metadata_2025 huggingface dataset:
Recurrent Schwannomatosis of the Hand
Authors: Nicolescu Razvan , Agrawal Nikhil A. , Pettit Rowland W. , Netscher David T.
Published: January 2020

Background: Peripheral nerve sheath tumors (PNSTs) are neoplastic soft tissue masses generated from the abnormal proliferation of Schwann cells. Often, these tumors occur in isolation and are known as schwannomas or neurilemmomas. The presence of multiple schwannomas is known as schwannomatosis. The purpose of this article is 2-fold: (1) to review the relevant literature and describe a unique case of this rare condition; and (2) to emphasize salient clinical considerations in the diagnosis and treatment of schwannomatosis. Methods: In this report, we describe the case of a 52-year-old white man who presented with multiple recurrent soft tissue masses of the right hand. On initial presentation, he described pain across his right hand and index finger, which persisted despite numerous prior operations. The index finger had a flexion contracture around the location of the proximal interphalangeal joint, and there were multiple tender masses along the length of the finger and palm. Results: Segmental excision of the affected radial digital nerve was performed. A pulp flap based on contralateral neurovascular bundle resulted in a sensate, pain-free digit. Tissue pathology confirmed the diagnosis of multiple neurilemmomas. Conclusions: We report the success of a radial digital neurectomy in a patient with widespread neurilemmomas, who had previously excluded that painful digit from use. It was through careful consideration of the preoperative differential diagnosis, by valuing the preoperative imaging, and by considering all surgical options with specific attention paid to skin flap design that this good outcome of a fully sensate, pain-free, mobile index finger was achieved.
PTP1B Inhibitory Flavonoids From Orthosiphon stamineus Benth. and Their Growth Inhibition on Human Breast Cancer Cells
Authors: To Dao-Cuong , Hoang Duc-Thuan , Tran Manh-Hung , Pham Minh-Quan , Huynh Nhu-Tuan , Nguyen Phi-Hung
Published: January 2020

In our preliminary screening study on the protein tyrosine phosphatase 1B (PTP1B) inhibitory and cytotoxic activities, an ethyl acetate soluble fraction of the aerial part of Orthosiphon stamineus Benth. was found to inhibit PTP1B activity. Thus, based on assay-guided isolation of this active fraction, ten compounds (1-10) were purified and evaluated for their inhibitory effects on PTP1B and their growth inhibition on MCF7, tamoxifen-resistant MCF7 (MCF7/TAMR), and MDA-MB-231 human breast cancer cell lines. Among the isolates, compounds 5, 6, 9, and 10 showed potencies against PTP1B with IC50 values of 9.76, 10.12, 6.88, and 8.92 μM, respectively, followed by compounds 1 and 4 with IC50 values of 16.92 and 22.25 μM. Kinetic study showed that the active compounds (1, 5, 9, and 10) possessed mixed-competitive inhibition, which was similar to the positive control (ursolic acid, IC50 value of 3.42 μM, mixed-competitive). The others showed noncompetitive inhibition (4 and 6). In addition, all these active compounds (1, 4-6, and 9-10) displayed growth inhibition on three cancer cell lines, especially the most PTP1B inhibitory flavanones (9 and 10) exhibited comparable inhibitory effects on MCF7, MCF7/TAMR, and MDA-MB-231 cancer cells (IC50 values of 11.5 and 15.4, 8.9 and 10.5, and 17.6 and 21.3 μM, respectively) with tamoxifen, the positive control used in this assay (IC50 values of 11.9, 12.1, and 12.7 μM, respectively). The results suggest that these active constituents from O. stamineus might be considered as new natural compounds for the development of anticancer agents via PTP1B inhibition.
Toward Improving Hotel Prognostications Through the Application of Probabilistic Methodologies
Authors: O’Neill John W. , Bloom Barry A. N. , Sharma Amit
Published: January 2020

Existing and generally accepted methodologies for developing projections of future hotel performance have been recently described as “grossly inadequate” and we note they have essentially remained unchanged for decades. Notably, current methodologies result in point estimates of future performance and do not adequately consider the inherent risk in lodging investments. Borrowing from research in other fields, and particularly from the area of finance, we suggest the use of probabilistic, that is, stochastic methodologies. In particular, we recommend hotel investors, operators, and analysts use Monte Carlo simulation. Also, this article provides information regarding why probabilistic methodologies are appropriate and general guidance regarding how to apply such approaches.
Evaluation of the Consistency and Composition of Commercially Available Bone Marrow Aspirate Concentrate Systems
Authors: Dragoo Jason L. , Guzman Roberto A.
Published: January 2020

Background:

Bone marrow aspirate (BMA) concentrate (BMAC) has gained popularity as a treatment modality for various orthopaedic conditions; however, there are still inconsistencies in its reported therapeutic efficacy. This may be because of the many different commercial BMAC preparation systems used clinically, which generate dissimilar concentrate products.

Purpose:

To compare 3 commercially available BMAC preparation systems: Harvest SmartPrep 3, Biomet BioCUE, and Arthrex Angel. We evaluated the consistency of each of these systems and compared the composition of their concentrate products.

Study Design:

Controlled laboratory study.

Methods:

A total of 10 patients donated whole blood and BMA, which were combined and processed with the 3 different BMAC preparation systems. Samples were taken before and after processing for the measurement of white blood cells (WBC), platelets (PLT), CD34+ cells, and colony-forming unit–fibroblast (CFU-F). To evaluate consistency, the variances of cell yield and concentration increase from baseline for each cell type were compared between systems. To compare concentrate product composition, differences between the systems’ mean cell yield and concentration increase from baseline for each cell type were evaluated.

Results:

The Harvest system (variance, 0.25) concentrated WBC more consistently than the Arthrex system (variance, 3.25) ( P = .024), but no other differences in consistency were noted between the 3 systems. The Harvest system recovered the greatest percentage of CFU-F (82.4% ± 18.2%), CD34+ cells (81.1% ± 28.5%), and WBC (77.3% ± 8.6%), whereas the Biomet system recovered the greatest percentage of PLTs (92.9% ± 27.3%). The Arthrex system concentrated PLT to the greatest degree (11.10 ± 2.05 times baseline), while the Biomet system concentrated WBC to the greatest degree (5.99 ± 1.04 times baseline).

Conclusion:

The consistency of the 3 systems was similar for all but 1 of the evaluated cell types. However, the composition of the concentrate products differed across systems. This may grant each system unique advantages without having to sacrifice reproducibility.

Clinical Relevance:

Understanding the consistency of different BMAC preparation systems and their product makeup may aid in determining optimal therapeutic doses of different cell types.
Piphillin predicts metagenomic composition and dynamics from DADA2-corrected 16S rDNA sequences
Authors: Narayan Nicole R. , Weinmaier Thomas , Laserna-Mendieta Emilio J. , Claesson Marcus J. , Shanahan Fergus , Dabbagh Karim , Iwai Shoko , DeSantis Todd Z.
Published: January 2020

Background

Shotgun metagenomic sequencing reveals the potential in microbial communities. However, lower-cost 16S ribosomal RNA (rRNA) gene sequencing provides taxonomic, not functional, observations. To remedy this, we previously introduced Piphillin, a software package that predicts functional metagenomic content based on the frequency of detected 16S rRNA gene sequences corresponding to genomes in regularly updated, functionally annotated genome databases. Piphillin (and similar tools) have previously been evaluated on 16S rRNA data processed by the clustering of sequences into operational taxonomic units (OTUs). New techniques such as amplicon sequence variant error correction are in increased use, but it is unknown if these techniques perform better in metagenomic content prediction pipelines, or if they should be treated the same as OTU data in respect to optimal pipeline parameters.

Results

To evaluate the effect of 16S rRNA sequence analysis method (clustering sequences into OTUs vs amplicon sequence variant error correction into amplicon sequence variants (ASVs)) on the ability of Piphillin to predict functional metagenomic content, we evaluated Piphillin-predicted functional content from 16S rRNA sequence data processed through OTU clustering and error correction into ASVs compared to corresponding shotgun metagenomic data. We show a strong correlation between metagenomic data and Piphillin-predicted functional content resulting from both 16S rRNA sequence analysis methods. Differential abundance testing with Piphillin-predicted functional content exhibited a low false positive rate (< 0.05) while capturing a large fraction of the differentially abundant features resulting from corresponding metagenomic data. However, Piphillin prediction performance was optimal at different cutoff parameters depending on 16S rRNA sequence analysis method. Using data analyzed with amplicon sequence variant error correction, Piphillin outperformed comparable tools, for instance exhibiting 19% greater balanced accuracy and 54% greater precision compared to PICRUSt2.

Conclusions

Our results demonstrate that raw Illumina sequences should be processed for subsequent Piphillin analysis using amplicon sequence variant error correction (with DADA2 or similar methods) and run using a 99% ID cutoff for Piphillin, while sequences generated on platforms other than Illumina should be processed via OTU clustering (e.g., UPARSE) and run using a 96% ID cutoff for Piphillin. Piphillin is publicly available for academic users (Piphillin server. http://piphillin.secondgenome.com/.)
Fatal hemorrhagic varicella in a patient with abdominal pain: a case report
Authors: Zhang Wei , Ruan Qiao-ling , Yan Fang , Hu Yue-kai
Published: January 2020

Background

Varicella is normally a self-limited childhood disease caused by varicella-zoster virus infection. However, it sometimes causes severe diseases, especially in immunocompromised individuals. We report a case of severe varicella in a young woman.

Case presentation

A 19-year-old woman presented to the emergency department with abdominal pain and a rash after taking methylprednisolone for 2 weeks for systemic lupus erythematosis. The laboratory data showed leukocytosis, thrombocytopenia, an elevated level of the liver transaminases and disseminated intravascular coagulation. Computed tomography of the abdomen revealed multiple air-fluid levels in the intestines. Hemorrhagic varicella was considered and antiviral therapy as well as immunoglobin were applied. Her condition deteriorated and she eventually died due to multi-organ failure and refractory shock. Next-generation sequencing performed on fluid from an unroofed vesicle confirmed the diagnosis of varicella.

Conclusion

In its severe form, VZV infection can be fatal, especially in immunocompromised patients. Hemorrhagic varicella can be misdiagnosed by clinicians because of unfamiliar with the disease, although it is associated with a high mortality rate. In patients with suspected hemorrhagic varicella infection, antiviral therapies along with supportive treatment need to be initiated as soon as possible in order to minimize the case fatality rate.
Preoperative clinical factors and visual outcomes following orbital decompression with dysthyroid optic neuropathy
Authors: Tagami Mizuki , Honda Shigeru , Azumi Atsushi
Published: January 2020

Background

To investigate preoperative clinical factors and visual outcomes of Japanese patients with dysthyroid optic neuropathy (DON) after urgent orbital decompression.

Methods

This retrospective, observational case series study investigated 44 patients who exhibited several preoperative clinical factors that might be associated with the need for urgent orbital decompression due to DON. Additionally, the visual acuity of DON patients was compared between the patients preoperatively and at 1 and 6 months postoperatively.

Results

All 44 patients received steroid and with or without radiation therapy, with 27 patients able to avoid undergoing urgent surgery. However, the remaining 17 patients required urgent orbital decompression following a lack of response to the therapy. None of the patients who initially avoided surgery required additional surgery for DON. Factors significantly associated with the need for urgent orbital decompression surgery included: female gender, older age, long disease duration, unilateral significant DON, history of resistance to pulsed steroid therapy, unstable thyroid function, high TRAb (Thyrotrophin receptor antibody)value, poor visual acuity, presence of central diplopia, and presence of corneal problems (P < 0.05 each). The results also showed that postoperative visual outcomes of surgery for DON were acceptable.

Conclusion

This study revealed several preoperative clinical factors for DON that appear to be associated with the need for urgent orbital decompression surgery in Japanese patients.
Surgical treatment of mild to moderately dilated ascending aorta in bicuspid aortic valve aortopathy: the art of safety and simplicity
Authors: Zhu Peng , Zhou Pengyu , Ling Xiao , Ohene Bright Eric , Bian Xiao Ming , Jiang Xiaoxiao
Published: January 2020

Background

Evaluate the safety and efficacy of our modified technique of the extravascular procedure for treating mild to moderately dilated ascending aorta in patients with bicuspid aortic valve (BAV) aortopathy.

Methods

From January 2015 to December 2018,119 consecutive patients with BAV and ascending aorta dilatation (dimension 40 mm~ 45 mm) were diagnosed in our institution. Among these,49 patients received aggressive aortic valve replace (AVR) + ascending aorta wrapped (wrapped group) while the other 70 patients received AVR + ascending aorta replacement (wheat group). All patients clinical and follow up data were collected for 12 months.

Results

Aortic clamping and cardio-pulmonary bypass times were significantly longer in wheat group than wrap group (P < 0.001and 0.021,respectively). The first 24 h drainage in wheat group were much more than wrap group(P = 0.04). Ascending aorta diameter、left ventricular end diameter and ejection fraction were statistically different between pre- and post-operation (p < 0.001) in both groups, but the heart function and complication were no difference during follow up.

Conclusions

External wrapping of the ascending aorta and wheat procedure have good short-term and long-term results in BAV patients with a mild to moderately dilated ascending aorta. The perioperative period results of external wrapping of the ascending aorta for BAV patients were encouraging.
Digital governance in tax-funded European healthcare systems: from the Back office to patient empowerment
Authors: Mattei Paola
Published: January 2020

Digital healthcare promises to achieve cost-efficiency gains, improve clinical effectiveness, support better public sector governance by enhancing transparency and accountability, and increase confidence in medical diagnoses, especially in the field of oncology. This article aims to discuss the benefits offered by digital technologies in tax-based European healthcare systems against the backdrop of structural bureaucratic rigidities and a slow pace of implementation.

Artificial intelligence (AI) will transform the existing delivery of healthcare services, inducing a redesign of public accountability systems and the traditional relationships between professionals and patients. Despite legitimate ethical and accountability concerns, which call for clearer guidance and regulation, digital governance of healthcare is a powerful means of empowering patients and improving their medical treatment in terms of quality and effectiveness. On the path to better health, the use of digital technologies has moved beyond the back office of administrative processes and procedures, and is now being applied to clinical activities and direct patient engagement.
Dual energy CT findings in gout with rapid kilovoltage-switching source with gemstone scintillator detector
Authors: Svensson Elin , Aurell Ylva , Jacobsson Lennart T. H. , Landgren Anton , Sigurdardottir Valgerdur , Dehlin Mats
Published: January 2020

Background

A definite diagnosis of gout requires demonstration of monosodium urate crystals in synovial fluid or in tophi, which in clinical practice today seldom is done. Dual energy CT (DECT) has repeatedly been shown to be able to detect monosodium urate crystals in tissues, hence being an alternative method to synovial fluid microscopy. The vast majority of these studies were performed with CT scanners with two X-ray tubes. In the present study we aim to investigate if and at what locations DECT with rapid kilovoltage-switching source with gemstone scintillator detector (GSI) can identify MSU crystals in patients with clinically diagnosed gout. We also performed a reliability study between two independent readings.

Methods

Patients with new or established gout who had been examined with DECT GSI scanning of the feet at Sahlgrenska University Hospital, Mölndal between 2015 and 2018 were identified. Their medical records were sought for gout disease characteristics using a structured protocol. Urate deposits in MTP1, MTP 2–5, ankle/midfoot joints and tendons were scored semiquantatively in both feet and presence of artifacts in nail and skin as well as beam hardening and noise were recorded. Two radiologists performed two combined readings and scoring of the images, thus consensus was reached over the scoring at each occasion (Espeland et al., BMC Med Imaging. 2013;13:4). The two readings were compared with kappa statistics.

Results

DECT GSI could identify urate deposits in the feet of all 55 participants with gout. Deposits were identified in the MTP-joints of all subjects but were also present in ankle/midfoot joints and tendons in 96 and 75% respectively. Deposition of urate was predicted by longer disease duration (Spearman’s Rho 0.64, p < .0001) and presence of tophi (p = 0.0005). Artifacts were common and mostly found in the nails (73%), a minority displayed skin artifacts (31%) while beam hardening and noise was rare. The agreement between the two readings was good (Κ = 0.66, 95% CI = 0.61–0.71).

Conclusion

The validity of DECT GSI in gout is supported by the identification of urate in all patients with clinical gout and the good correlations with clinical characteristics. The occurrence of artifacts was relatively low with expected locations.
Direction of the relationship between methamphetamine use and positive psychotic symptoms in regular methamphetamine users: evidence from a prospective cohort study
Authors: Hides Leanne , Chan Gary , Dawe Sharon , McKetin Rebecca , Kavanagh David J. , Young Ross McD , Teesson Maree , Saunders John B.
Published: January 2020

Background

Methamphetamine has been consistently associated with positive psychotic symptoms, but little is known about whether the reverse also occurs.

Aims

This study determined whether the relationship between methamphetamine use and positive psychotic symptoms is bidirectional over 12 months. The impact of lifetime psychotic disorders and methamphetamine dependence on these relationships was also examined.

Method

A total of 201 regular (at least monthly) primary methamphetamine users were recruited from free needle and syringe programmes in three Australian cities. Data on the frequency of methamphetamine and other drug use (from Timeline Followback inteviews) and the severity of positive psychotic symptoms (using the Brief Psychiatric Rating Scale) in the past 2 weeks were collected in 12 contiguous monthly face-to-face interviews (mean of 9.14/11 (s.d. = 3.16) follow-ups completed). Diagnoses were derived using the Psychiatric Research Interview for DSM-IV Substance and Mental Disorders.

Results

The mean age of participants was 31.71 years (s.d. = 8.19) and 39% (n = 77) were women. At baseline 55% (n = 110) were dependent on methamphetamine and 51% (n = 102) had a lifetime psychotic disorder. Cross-lagged dynamic panel models found a significant bidirectional relationship between psychotic symptoms and methamphetamine use (Comparative Fit Index (CFI) = 0.94, standardised root mean square residual (SRMR) = 0.05, root mean square error of approximation (RMSEA) = 0.05, 95% CI 0.04–0.06). The magnitude of the relationship in each direction was similar, and the presence of methamphetamine dependence or a lifetime psychotic disorder did not have an impact on results.

Conclusions

A dynamic, bidirectional relationship between methamphetamine and psychotic symptoms of similar magnitude in each direction was found over 1 year. This suggests integrated treatments that target methamphetamine, psychotic symptoms and their interrelationship may be of most benefit.
New approach and new permutation tests with R programs for analyses of false negatives-contaminated data in medicine and biology
Authors: Flegr Jaroslav , Tureček Petr
Published: January 2020

Statistically, the concentration of antibodies against parasites decreases with the duration of infection. This can result in false negative outcomes of diagnostic tests for subjects with old infections. When a property of seronegative and seropositive subjects is compared under these circumstances, the statistical tests can detect no difference between these two groups of subjects, despite the fact that they differ. When the effect of the infection has a cumulative character and subjects with older infections are affected to a greater degree, we may even get paradoxical results of the comparison – the seropositive subjects have, on average, a higher value of certain traits despite the infection having a negative effect on those traits. A permutation test for the contaminated data, implemented, e.g., in the program Treept or available as a comprehensibly commented R function at https://github.com/costlysignalling/Permutation_test_for_contaminated_data, can be used to reveal and to eliminate the effect of false negatives. A Monte Carlo simulation in the program R showed that our permutation test is a conservative test – it could provide false negative, but not false positive, results if the studied population contains no false negative subjects. A new R version of the test was expanded by skewness analysis, which helps to estimate the proportion of false negative subjects based on the assumption of equal data skewness in groups of healthy and infected subjects. Based on the results of simulations and our experience with empirical studies we recommend the usage of a permutation test for contaminated data whenever seronegative and seropositive individuals are compared.
Retrospective cohort study monitoring PEG-asparaginase activity in acute lymphoblastic leukemia patients with and without premedication
Authors: Losasso Michael , Bostrom Bruce , Messinger Yoav
Published: January 2020

Background: PEG-L-asparaginase (pegaspargase) is a critical component of therapy for children and adults with acute lymphoblastic leukemia (ALL). Allergic reactions, which may occur in up to one third of patients, are the major cause for discontinuation. One study reported lower rates of allergic reactions with premedication. Besides allergy, an unknown number of patients develop silent neutralizing antibodies not associated with allergic reactions. The purpose of this retrospective cohort study was to determine the incidence of silent inactivation of pegasparaginase and compare incidence of allergic reactions with and without premedication.

Methods: Using a commercial assay, asparaginase activity was monitored following pegaspargase (2500 units/m ) in newly diagnosed children and young adults with B- and T-cell ALL from February 2013 to May 2017. The incidence of allergic reactions before and after initiation of premedication in May 2015 was compared.

Results: One patient out of 59 (1.7%) had silent inactivation after the second dose. No patient had silent inactivation after the first pegaspargase dose and no standard risk B-cell ALL patients, who received only two pegaspargase doses in combination with oral dexamethasone, had silent inactivation. The incidence of grade 3 or 4 allergic reactions was 3.7% per dose with premedication (methylprednisolone, acetaminophen and diphenhydramine) versus 5.2% without. The incidence per patient with premedication given for most of the doses was 8.3% versus 17% without. These values are not statistically significant. Premedication did not affect pegaspargase activity.

Conclusions: Due to the low incidence of silent inactivation with intravenous pegaspargase and the unlikely event patients receiving only two doses of pegasparaginase would receive erwinase for this possible transient silent inactivation, we recommend routine monitoring of pegaspargase activity only in patients scheduled to receive more than two doses.
Are we underutilizing bone marrow and cord blood? Review of their role and potential in the era of cellular therapies
Authors: Xue Elisabetta , Milano Filippo
Published: January 2020

Since the first hematopoietic stem cell transplant, over a million transplants have been performed worldwide. In the last decade, the transplant field has witnessed a progressive decline in bone marrow and cord blood utilization and a parallel increase in peripheral blood as a source of stem cells. Herein, we review the use of bone marrow and cord blood in the hematopoietic stem cell transplant setting, and we describe the recent advances made in different medical fields using cells derived from cord blood and bone marrow.
Making the invisible visible: the availability and desirability of adherence data in routine CF care– findings from a national questionnaire survey
Authors: Robinson Louisa , Maguire Chin , Hoo Zhe Hui , Wildman Martin J.
Published: January 2020

Background: Inhaled medications for cystic fibrosis (CF) are effective but adherence is low. Clinicians find it difficult to estimate how much treatment people with CF (PWCF) take, whilst objective adherence measurement demonstrates that patients are poorly calibrated with a tendency to over-estimate actual adherence. The diagnostic approach to a PWCF with deteriorating clinical status and very low adherence is likely to be different to the approach to a deteriorating patient with optimal adherence. Access to objective adherence data in routine consultations could help to overcome diagnostic challenges for clinicians and people with CF. Attitudes of clinicians to the use and importance of routinely available adherence data is unknown.

Methods: We conducted an online questionnaire survey with UK CF centres. We asked five questions relating to the current use and perception of objective measurements of adherence in routine care.

Results: A total of eight CF centres completed the questionnaire. Few of the responding centres have adherence data readily available in routine clinics (13% of centres use medicines possession ratio; of centres with access to I-nebs® it was estimated that 17% of patients had I-neb data regularly available in clinics). All centres considered the availability of objectively measured adherence data to be important. Respondents identified that systems developed to provide adherence data in clinical practice must provide data to both clinicians and patients that is readily understood and easy to use.

Conclusions: Centres perceived the availability of adherence data in routine care to be important but objective measures of adherence is rarely available at present.
Identifying orthologs with OMA: A primer
Authors: Zahn-Zabal Monique , Dessimoz Christophe , Glover Natasha M.
Published: January 2020

The Orthologous Matrix (OMA) is a method and database that allows users to identify orthologs among many genomes. OMA provides three different types of orthologs: pairwise orthologs, OMA Groups and Hierarchical Orthologous Groups (HOGs). This Primer is organized in two parts. In the first part, we provide all the necessary background information to understand the concepts of orthology, how we infer them and the different subtypes of orthology in OMA, as well as what types of analyses they should be used for. In the second part, we describe protocols for using the OMA browser to find a specific gene and its various types of orthologs. By the end of the Primer, readers should be able to (i) understand homology and the different types of orthologs reported in OMA, (ii) understand the best type of orthologs to use for a particular analysis; (iii) find particular genes of interest in the OMA browser; and (iv) identify orthologs for a given gene.  The data can be freely accessed from the OMA browser at https://omabrowser.org.
Modern treatment of symptomatic apical periodontitis after chemotherapy in a breast cancer patient. Case report
Authors: Filon Andrii
Published: January 2020

The problem of providing dental care to patients with cancer has been and remains very relevant. According to the National Cancer Institute, in Ukraine there are more than a million people suffering from cancer. Every 3-4 men and every fifth woman are at risk of developing cancer. Studies of the state of the oral cavity in this category of patients have established a high prevalence of dental diseases and, as a result, a significant need for dental care (1, 2). There is a direct correlation between the state of oral hygiene and the severity of cancer (3, 4).The results confirm that the destruction of the infection in the root canal leads to the regeneration of periapical bone damage. The size of the lesion does not affect the treatment tactics. Large-scale periapical inflammatory processes are amenable to therapeutic treatment. Chemotherapy has been shown to significantly affect the condition of the oral cavity and exacerbate chronic inflammatory processes. This issue is subject to further study and development of special dental treatment for cancer patients.
Influence of magnesium on excitability of neurons of different levels of their organization
Authors: Antonenko S. A.
Published: January 2020

AbstractThe article indicates that the hyper-excitability of neurons is associated with ionic imbalance of cell membranes, in which a number of trace elements are involved. The energy component of these processes is associated with the presence of magnesium (Mg) as a universal supplier of the latter. Mg supports the functioning of NMDA receptors, which does not allow the excitotoxic effects of glutamate, which triggers the mechanisms of Ca entry into the neuron and its death, to manifest itself. Mg stimulates the main excitatory neurotransmitter acetylcholine, regulates the release of serotonin, glycine, dopamine, thereby normalizing the extrapyramidal system, the spinal stem structures, and the final executive motor apparatus. Participates in the energy support of adaptation processes, the activation of central regulatory mechanisms, control the excess of catecholamines and corticosteroids, other hormones and mediators involved in stress reactions.
The quality of life of people with slow-healing wounds is strengthened through the introduction of therapeutic and nursing activities administered in long-term homecare nursing, as based on case studies
Authors: Kołodziejczyk Monika , Stasiak Elżbieta , Stasiak Karolina , Stasiak Łucja , Grzegorczyk Michał
Published: January 2020

The quality of life of people with slow-healing wounds is a multi-faceted concept which focuses on the functioning of patients in many spheres of life.Two characteristics of patients qualified for long-term homecare nursing are multi-morbidities and senior age. The coexistence of several chronic diseases, including atherosclerosis, is associated with the presence of a number of healing and caring problems, for example, slow-healing wounds. The social security in Poland in the domain of long-term homecare nursing is at a very low level, as reported by the Central Statistical Office in 2015, with only 4 out of 1000 people using  long-term nursing care in a home environment.
The Smash Ability in Volleyball Games: The experimental study of teaching style and motor ability
Authors: Halim Abdul , Tangkudung James , Dlis Firmansyah
Published: January 2020

Smash Ability in low volleyball games can affect to the student achievement. This study as a whole aims to determine the impact of differences and interactions from teaching styles and motor skills on the achievement of smash ability in volleyball games. This research method uses an experiment of treatment by level 2x2 design. This research was conducted in National High School of 4 Sinjai Timur, the study sample was 54 students in grade 8. The results of this study indicate that: (1) there is a significant difference in influence between self-check teaching styles and reciprocal to the outcomes of volleyball smash ability learning, (2) there is a significant interaction influence between teaching styles and motor ability to the outcomes of volleyball smash ability learning, (3) there is a significant differences of the smash ability in volleyball games using a self-check teaching styles and reciprocal in groups of students with high motor skills, and (4) there is a significant differences of the smash ability in volleyball games using a self-check teaching styles and reciprocal in groups of students with low motor ability.
The need for social support for patients suffering from brain tumour
Authors: Celej-Szuster Jolanta , Polit Magda , Przychodzka Elżbieta , Piasecka Katarzyna , Turowski Krzysztof , Łuczyk Robert Jan
Published: January 2020

Introduction. Central nervous system tumours establish a group of benign and malignant tumours stemming from various nervous system cells [1]. In every stage of cancer the patient needs help and support compensating the deficits in psychophysical health. The term “social support” is used interchangeably with the following expressions: help, relationships, bonds, social relationships, connections [5,6]. Objective. The aim of the study was to assess the need for social support for patients suffering from brain tumour. Results. For patients suffering from brain tumour the most needed form of support is emotional. Conclusions. There is a relationship between certain sociodemographic data (marital status, family type) and the need for a certain kind of social support (personal or professional/formal support).
Knowledge of Nursing Personnel of the Świętokrzyskie Voivodeship Hospitals on Nosocomial Infections
Authors: Wrześniewska Marzena , Gruszka Jakub , Komar-Gruszka Karolina , Bąk Beata , Adamczyk-Gruszka Olga
Published: January 2020

Introduction: Nosocomial (also known as hospital-acquired) infections are understood as infections which develop during patient’s stay in hospital, but are not the direct cause of hospitalisation. The aim of the study: The purpose of the paper was to determine the knowledge of the nursing personnel from Świętokrzyskie Voivodeship onnosocomial infections, prevention and methods of combating them. Other addressed issues included the analysis of the work yeas and education level as related to the state of nurses' knowledge on nosocomial infections, and what are the reasons for insufficient prevention of diseases. Material and methods: The study included 208 nurses from Świętokrzyskie Voivodeship. Out of 208 questionnaires, 180 were completed correctly, the remaining 28 were answered incorrectly or incompletely, which resulted in their rejection. The statistical analysis was conducted using the Pearson Chi-squared method, with the significance level p>0.01 assumed to be insignificant. The study involved 124 women and 56 men. The youngest respondent was 23 years old and the oldest was 59 years old. There were 36 respondents below 30 years of age(20%), 88 in the 31-40 age group (48.9%), 56 in the 41-60 age group (31.1%). Results 1. The knowledge of the intermediate personnel about hospital-acquired infections is satisfactory. 2. Job seniority is not statistically significant with regard to the knowledge level on nosocomial infections. 3. The research revealeda statistically significant correlation between the knowledge level of the secondary staff and their education. 4. The study results show that the most common causes of insufficient knowledge on preventing hospital-acquired infections are staff shortages and inadequatefinancial resources.
The Influence of Discipline and Body Fitness to The Performance of Physical Education Teachers
Authors: Asrianti Asrianti , Tangkudung James , Dlis Firmansyah , Asmawi Mochammad , Hanif Achmad Sofyan , Muchtar Jufrianis
Published: January 2020

The purpose of this study was to determine the effect of discipline and physical fitness on the performance of physical education teachers. This study uses the path analysis method. This research to find the direct effect between variables discipline and physical fitness on the work of physical education teachers. The sample used 102 certified physical education teachers in the province of Southeast Sulawesi. Discipline and performance are measured using questionnaires that have been validated by experts. Physical fitness is measured by using five items of fitness tests namely body lift test for men and elbow bend for girls, sit-ups, push-ups running back and forth and also endurance that is running with a distance of 2.4 km. Data analysis technique used path analysis. The finding of the variable such as, 1) discipline variable (X2) has a direct positive effect on teacher performance (Y), amounting to (R2 = 0.160). 2) physical fitness variable (X3) has a direct positive effect on teacher performance (Y), amounting to (R2 = 0.376), 3) discipline variable (X2) has a direct positive effect on physical fitness (X3), amounting to (R2 = 0.889). Based on the two independent variables that gave the greatest contribution to improving the performance of physical education teachers was physical fitness (R2 = 0.376). In this case a teacher who has good physical fitness will also have good performance.
ANALISIS PERBANDINGAN KINERJA KEUANGAN SEBELUM DAN SESUDAH MERGER-AKUISISI PADA PERUSAHAAN YANG TERDAFTAR DI BURSA EFEK INDONESIA (BEI) PERIODE 2015
Authors: Putro Dimas Nur Setiantoso , Kusuma Desta Rizky
Published: January 2020

This study is entitled comparative analysis of financial performance before and after mergers-acquisitions in companies listed on the Indonesia Stock Exchange (IDX) Period 2015. The purpose of this study is to determine differences in financial performance before and after mergers and acquisitions of companies listed on the IDX measured using the ratio Total Asset Turnover, Return On Asset, and Net Profit Margin with Purposive Sampling techniques. This type of data source is secondary data taken from the official website of the Indonesia Stock Exchange (www.idx.co.id). The data taken is the data of financial statements and annual reports and sampling conducted with certain criteria. The population used in this study are companies that have merged and are listed on the Indonesia Stock Exchange, as many as 15 companies. The choice of location or place of research on the Indonesia Stock Exchange (IDX) through the official website www.idx.co.id (2019), the reason for choosing this location is because all data such as financial statements can be trusted. Based on the determined sample criteria from 15 merger-acquisition companies listed on the Indonesian Stock Exchange (IDX), 12 sample companies were obtained that met these criteria. The data analysis method used is descriptive analysis to analyze data by describing or describing the data that has been collected as it is without making conclusions that apply to the public or generalizations. Then the data collected was tested for normality and paired sample t-test with the help of the SPSS 22 application program.
KUALITAS PELAYANAN SEBAGAI DETERMINAN KEPUASAN PELANGGAN JASA TRANSPORTASI GRAB BIKE DI YOGYAKARTA
Authors: Ramadhan Fajar , Setyono Hendro
Published: January 2020

This  research  aims  to  analyze  the  influence  of  the  quality  of  service  of customer  satisfaction  on  service  businesses  Grab-Bike  transport  in  Yogyakarta. This  research  uses  the  five  independent  variables  i.e.  tangible,  reliability, responsiveness,  assurance  and  emphaty  with  one  dependent  variable  i.e. consumer  satisfaction.  After  a  review  of  the  literature  as  well  as  field  and preparation  of  the  hypothesis,  the  data  in  this  study  were  collected  through  the dissemination  of  a  questionnaire  to  70  people  who  never  use  the  Grab-Bike transport  as  research  samples.  Sampling  technique  used  is  a  Non  probability sampling  method  sampling  incidental.  Methods  of  data  analysis  used  is  the quantitative analysis that is test validity and reliability, multiple linear regression analysis,  t-test  and  F-test  as  well  as  the  coefficient  of  determination.  Based  on data  analysis,  the  results  showed  that  the  indicators  on  research  is  valid  and reliability.  Hypothesis  test  on  tangible,  responsiveness,  assurance  and  emphaty no effect significantly to consumer satisfaction. Hypothesis test of reliability has a positive and significant influence toward customer satisfaction.
PENGARUH KINERJA KEUANGAN TERHADAP HARGA SAHAM PADA PERUSAHAAN PROPERTI DAN REAL ESTATE YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Wardana Made Galih Wisnu , Fikri Muhammad Ali
Published: January 2020

This research aims to determine the effect of liquidity ratio (CR), solvency ratio (DER), profitability ratio (ROA), and activity ratio (TATO) on the Stock Price. The object that  is  used in this research are property and real estate sub sector companies listed in Indonesia Stock Exchange year 2015-2017. The population in this research is a whole of property and real estate sub sector companies listed in Indonesia Stock Exchange year 2015-2017 were 48 companies. The sampling technique is used purposive sampling with several criteria,  namely property and real estate sub sector companies listed in Indonesia Stock Exchange year 2015-2017, companies that submit financial reports during the research period, and companies that have positive net income report. The number of samples that fit the criteria were 34  companies. Data were analyzed by using data regression analysis with Eviews 6 software. The  results of this  research showed  that current  ratio, debt to equity ratio and total asset turn over are partially have positive and not have significant effect on the stock price, while return on assets have negative and not have significant effect on the stock price. Simultaneously that the current ratio, debt to equity ratio, return on assets and total asset turnover not have  significant effect on  the  stock price. R-square value of 0.019 indicates that the ability of the current ratio, debt to equity ratio, return on assets,  and  total  asset  turnover  while  explaining  the  Stock  Price  is  1.9%,  and  the 98.1% is explained by other variables which not contained in this research.
PENGARUH KEPUASAN KERJA, KOMITMEN ORGANISASI DAN BUDAYA ORGANISASI TERHADAP ORGANIZATIONAL CITIZENSHIP BEHAVIOR
Authors: Dinniaty Nisa Mutia , Fitriani Dyah
Published: January 2020

This research aims to examine the effect of job satisfaction, commitment organization and organizational culture of organizational citizenship behavior partially at PT. Telkom Indonesia Yogyakarta, this research conducted in 2 places, namely PT. Telkom Indonesia Kota Baru and PT. Telkom Indonesia Pugeran. For the distribution of questionnaires as many as 98 respondents consisting from permanent employees through two stages, namely, the first to do the distribution of validity test questionnaires of 30 respondents, and the second did the distribution of analysis test questionnaires of 68 respondents. Sampling technique in this study using Multiple Linear Regression. Validity and realibility test of the questionnaire which was used as a tool showed that the questionnare is valid and reliable for use. Test result shows the variable Job Satisfaction has a significant effect on Organizational Citizenship Behavior for PT. Telkom Indonesia. Variable Organizational Commitment has a significant effect on Organizational Citizenship Behavior for PT. Telkom Indonesia. Organizational Culture Variable significant effect on Organizational Citizenship Behavior on employees PT. Telkom Indonesia.
Jurisdição e subordinação: tentativas de provincialização da Igreja no Piauí (1822-1830)
Authors: Sales João Vitor Araújo , Neto Marcelo De Sousa
Published: January 2020

O presente artigo analisa as primeiras tentativas de provincialização, apropriação política, da Igreja Católica no Piauí. Considerando que o Piauí esteve sob o controle político-administrativo do Maranhão até 1811, entende-se que as famílias pertencentes à elite econômica local atuaram de forma articulada no intuito de trazer para a província o controle sobre a Igreja, a partir da concepção desta enquanto estrutura de poder legítima, de modo a exercer jurisdição própria sobre o governo espiritual na forma de uma diocese ou organismo semelhante que atendessem seus interesseslocais. Para análise, investigou-se a atuação dos deputados piauienses nas Cortes de Lisboa (1822), bem como, da elite local nos primeiros órgãos de governo provincial: o Conselho de Presidência e o Conselho Geral. Percebeu-se, a partir das atas, discussões e resoluções dos representantes nos Conselhos, e a defrontação destas com a bibliografia concernente, que uma elite local coesa tentou reiteradamente territorializar a Igreja no âmbito da província do Piauí, de modo a exercer poder diretamente sobre ela, todavia, obstruído pela influência do prelado maranhense e a indiferença do Governo Central à causa do Piauí.
A Guerra do Contestado e a Lei de Terras imperial: um estudo de caso da Fazenda Figueiredo (Lages, 1855-1917)
Authors: Darossi Flávia Paula
Published: January 2020

Parte importante da guerra sertaneja do Contestado nasceu durante o Império, na luta camponesa por acesso à terra, sendo acrescida na República pela continuada resistência de posseiros, sitiantes e agregados contra o mandonismo local de grandes fazendeiros, criadores e comerciantes de gado e a usurpação de terras pelas companhias Brazil Railway e Lumber and Colonization. Este artigo tem como objetivo analisar a questão fundiária no período anterior à Guerra, durante o período Imperial, de modo a identificar a historicidade de experiências como o mandonismo local e a concentração fundiária na região. O método da pesquisa foi baseado na reconstrução de relações e discursos jurídicos de um estudo de caso localizado no município de Lages, segundo dois processos judiciais que envolveram questões de terras da fazenda “Figueiredo”, de 1876 a 1917. Concluiu-se que tanto o coronelismo quanto a concentração fundiária, combatidos pela maioria dos sertanejos do Contestado, são resultados do mesmo processo histórico da execução da Lei de Terras de 1850. O referido estudo de caso demonstrará a importância da política fundiária Imperial às pesquisas que buscam entender a historicidade do Planalto Catarinense durante a Primeira República.