bluuebunny/crossref_metadata_2025 huggingface dataset:
Farmacocinética de las Benzodiacepinas en Pacientes con Falla Hepática en UCI
Authors: Martínez Peredo Martín , Soler Sierra Andrea Gissette , Rivas García Valentina , Ingrid  , Mejía Serrano Natalia , Beltrán Lugo Mario Andrés , Baquero Álvarez Juan Felipe
Published: April 2024

Las benzodiacepinas son fármacos ampliamente usados para el tratamiento de los trastornos de insomnio y ansiedad,  como también en el uso de  anticonvulsivos, relajantes musculares, entre otros. A su vez hay que tener en cuenta que la mayoría de los fármacos por vía oral son liposolubles y su absorción va a depender de su velocidad e intensidad de la absorción gastrointestinal. Por lo tanto, las benzodiazepinas se caracterizan por una distribución rápida y un volumen de distribución amplio en equilibrio que se metabolizan en gran medida por efectos de diversos sistemas enzimáticos microsomicos en el hígado, lo que da como consecuencia la formación de metabolitos activos que se biotransforman con mayor lentitud que el compuesto original. Por ende hay que tener en cuenta su clasificación en la que va a depender de la duración de sus efectos de vida media, y la capacidad que tiene de provocar manifestaciones notorias como mareo, fatiga, aumento del tiempo de reacción, incordinación motora, confusión y amnesia anterógrada. Por consiguiente, es de vital importancia saber que al momento de elegir un fármaco hay que considerar las posibles implicaciones para cada una de las dosificaciones de este y los resultados de cada paciente,  ya que se tienen en cuenta cuatro fases importante en los factores clínicos como la aparición y la duración de los efectos del fármaco.
Terahertz Spectroscopy Analysis of Amyloid Fibrils Derived from Human Serum Albumin
Authors: Shakirah Wahida Shamsul Bahri  , Siti Nor Khadijah Addis  , Nur Farizan Munajat  , Nabilah Kasim  , Hidayatul Aini Zakaria
Published: April 2024

Amyloid fibrils, also referred to as protein fibrils, represent irregular assemblies of proteins exhibiting a cross-β configuration. Terahertz radiation, a segment of the electromagnetic spectrum spanning 0.3 to 10 terahertz (THz), is known to interact with these fibrils due to their cylindrical shape. This study's objective was to explore the potential of terahertz spectroscopy as a non-invasive means to detect the progressive growth of protein fibrils. In this investigation, human serum albumin (HSA) was synthetically induced to form protein fibrils. Confirmation of fibril formation was done by fluorescence spectroscopy, Fourier transform infrared (FTIR) spectroscopy, UV-Vis spectroscopy, and Terahertz time-domain spectroscopy (THz-TDS). To initiate the process, HSA was dissolved in distilled water at a concentration of 160 µM, followed by the addition of 60% ethanol to both samples for dilution. The HSA to Cu (II) ratio was maintained at 1:1 (160 µM) for stock solutions containing Cu (II). Subsequently, each set underwent a 6-hour heating phase at 65 °C to cultivate fibrils, which were then stored at room temperature for 30, 60, and 90 days before evaluation. Incubation of human serum albumin yielded amyloid fibrils as evidenced by ThT fluorescence, FT-IR spectroscopy revealed an emergence of fibrils within the amide I bands, extending from 1630 cm⁻¹ to 1650 cm⁻¹ and UV-Vis spectroscopy disclosed the augmentation of protein fibril absorbance over the incubation period. THz spectroscopy absorbance progressively heightened with prolonged heating of the protein fibrils due to the hydration shell surrounding them. Through these spectroscopic methods, it was elucidated that the fibrillation process led to the gradual development of β-sheet and unordered helix structures as well as the potential of THz spectroscopy as non-invasive tool for detection and monitoring of amyloidal diseases, promising insights into early diagnosis and treatment strategies.
Spectrally Efficient UAV Communications using Non-Orthogonal Multiple Access (NOMA)
Authors: Leun Ming Mei  , Muhammad Syahrir Johal  , Fakrulradzi Idris  , Norlezah Hashim
Published: April 2024

Non-orthogonal multiple access (NOMA) scheme with its share of benefits such as spectral efficiency and simultaneous support of massive connectivity, is one of the keys enabling technologies for upcoming 5G. However, in the context of UAV-assisted communication, existing literature mainly focuses on conventional orthogonal multiple access (OMA) which limits the spectral efficiency and number of simultaneous connections. Existing technologies are using LTE that only can serve 1 user per resource block. The user capacity nowadays is increased, so the existing technologies should be improved to higher user capacity such as 4 users per resource block. This research project focuses on the design of NOMA scheme for multiple users aiming to maximize the system capacity and spectral efficiency of Unmanned Aerial Vehicle (UAV) hotspot with baseline model and to simultaneously support mobile users. The proposed NOMA multi-users model is then compared with baseline model of 2 users per resource block in NOMA and OMA. The proposed NOMA model increases spectral efficiency, higher throughput and improved user fairness. The project only focuses on downlink communication with stationary users. The parameters measured are Bit Error Rate, Sum Rate, and Spectral Efficiency that depend on power allocation, altitude of UAV, and distance between UAV and users. Based on the simulation results, NOMA which employs Fractional Transmit Power Allocation (FTPA) algorithm has better performance in terms of sum-rate and spectral efficiency compared to those of OMA by as much as 650%. Results are also presented for various NOMA power allocation algorithms.
Virtual Reality Technology and Artificial Intelligence for Television and Film Animation
Authors: Shiva Krishna Reddy V.  , Kathiravan M.
Published: April 2024

Artificial intelligence technology has transformed television content and production methods and resulted in the development of a new generation of artificially intelligent Television. Popularising artificial intelligence technology improves television programme content, categories, cost, and efficiency. Virtual reality (VR) technology has been widely used in scientific study and everyday life; thus, its use in film and television animation (FTA) teaching has been researched to promote FTA learning. First, learning design uses dynamic environment modelling, real-time 3D graphic production, stereoscopic displays, sensors, and other VR technologies. These four issues were researched due to the present FTA primary teaching method. VR technology enhances FTA's basic training teaching, and the 3D animation course and VR technology increase professional skill course teaching. The application effect compares and analyses classroom satisfaction, comprehensive quality evaluation, and professional core curriculum effect. The VR technology group's thorough quality evaluation is significantly improved, and students' satisfaction with classroom atmosphere, teaching style, and teaching facilities is 85%, 78%, and 97.34%, respectively. This group can incorporate the new design process into animation modelling and finish the course design work well. Compared to traditional instruction, pupils are happier and harvest more. Thus, VR technology in FTA instruction can increase student engagement, efficiency, and professional knowledge and abilities. After analysing its application mode and effects, VR technology can be used in FTA teaching.
PENGARUH MODEL PEMBELAJARAN DISCOVERY LEARNING TERHADAP HASIL BELAJAR IPA SISWA KELAS SD
Authors: Wati Ni Nyoman Kurnia , Suastra I Wayan , Arnyana Ida Bagus
Published: April 2024

Tujuan penelitian ini adalah mengidentifikasi perbedaan yang signifikan hasil belajar IPA antara siswa yang mengikuti pembelajaran dengan dengan model discovery learning dan siswa yang mengikuti pembelajaran dengan model pembelajaran konvensional pada siswa SD. Penelitian ini merupakan jenis penelitian eksperimen semu. Rancangan penelitian yang digunakan adalah non equivalent post-test only control group design. Metode analisis data dalam penelitian ini menggunakan metode analisis statistik deskriptif dan statistik inferensial. Metode analisis data yang digunakan untuk menguji hipotesis dalam penelitian ini adalah uji-t sampel independent (tidak berkorelasi) dengan rumus polled  varians. Berdasarkan hasil analisis data dapat disimpulkan bahwa terdapat perbedaan hasil belajar IPA yang signifikan antara kelompok siswa yang mengikuti pembelajaran dengan model model discovery learning dan kelompok siswa yang mengikuti pembelajaran dengan model pembelajaran konvensional. Hal ini ditunjukkan dengan nilai rata-rata pada kelompok eksperimen 27,18 dan pada kelompok kontrol 21,65. Berdasarkan hasil perhitungan uji-t diperoleh thit sebesar 8,14 sedangkan, ttab adalah 1,9852. Hal ini berarti, thit lebih besar daripada ttab (thit > ttab), sehingga H0 ditolak dan H­1 diterima. Jadi dapat diinterpretasikan model discovery learning berpengaruh positif terhadap hasil belajar IPA siswa kelas IV SD.
PENGARUH MODEL PEMBELAJARAN SOMATIC, AUDITORY, VISUALIZATION, INTELLEGENCY (SAVI) TERHADAP HASIL BELAJAR PENDIDIKAN PANCASILA KURIKULUM MERDEKA BELAJAR
Authors: Dewi Asri Lidya Rosita , Tirtoni Feri
Published: April 2024

Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran SAVI terhadap hasil belajar siswa kelas IV SDN Keboananom Sidoarjo yaitu terdapat permasalahan rendahnya hasil belajar siswa pada pembelajaran Pendidikan Pancasila. Populasi penelitian yaitu 25 siswa. Metode penelitian ini menggunakan kuantitatif eksperimen, jenis penelitian Quasi Experiment,bentuk desain yang digunakan non-equivalent control grup design berbantuan software SPSS 26. Hasil penelitian menunjukkan bahwa untuk menguji hipotesis dan menjawab rumusan masalah teknik analisis    data menggunakan uji Independent Sample T-test. Hal tersebut dilihat dari nilai rata-rata saat diberi perlakuan model pembelajaran SAVI. Terdapat pengaruh penggunaan model pembelajaran SAVI terhadap hasil belajar pembelajaran Pendidikan Pancasila siswa kelas IV SDN Keboananom. Setelah dilakukan uji hipotesis menggunakan uji diperoleh rata-rata data pretest lebih kecil dibanding rata-rata data posttest. Diperoleh nilai Sig. (2- t Independent Sample T-Test tailed) lebih kecil dari 0,05 dan nilai ?????i???? lebih dari ????????????b artinya terdapat pengaruh penggunaan model pembelajaran SAVI terhadap hasil belajar Pendidikan Pancasila siswa kelas IV SDN Keboananom. Kesimpulan penelitian ini adalah penggunaan model pembelajaran SAVI siswa kelas IV berpengaruh positif dan signifikan terhadap hasil belajar Pendidikan Pancasila siswa kelas IV sehingga dapat dijadikan sebagai solusi dalam pembelajaran Pendidikan Pancasila di SDN Keboananom.
ANALISIS PEMECAHAN MASALAH MATEMATIKA PADA MAHASISWA CALON GURU MATEMATIKA DENGAN TIPE KECERDASAN LINGUISTIK DAN LOGIS-MATEMATIS
Authors: Ade Abimanyu Stevanus , Pratama Fika Widya
Published: April 2024

Jenis penelitian ini adalah deskriptif kualitatif. Tujuan penelitian ini untuk menganalisis kemampuan pemecahan masalah matematika mahasiswa calon guru matematika dengan tipe kecerdasan linguistik dan logis-matematis pada materi peluang berdasarkan teori Polya. Terdapat 4 tahapan pemecahan masalah menurut Polya: memahami masalah, merencanakan pemecahan, melaksanakan rencana, memeriksa kembali. Subjek dalam penelitian ini adalah mahasiswa calon guru matematika Universitas Kristen Satya Wacana (UKSW) Salatiga yang memiliki kecerdasan linguistik dan logis-matematis. Pengumpulan data dilakukan pada Agustus-September 2022 di UKSW Salatiga, adapun instrumen pendukung yang digunakan yaitu angket kecerdasan majemuk, tes tertulis dan wawancara. Uji keabsahan data menggunakan triangulasi teknik. Hasil penelitian ini yaitu subjek dengan kecerdasan linguistik dan logis-matematis hanya memenuhi 2 tahapan Polya, yaitu tahapan memahami masalah dan tahapan memeriksa kembali.
PENINGKATAN KEMAMPUAN NUMERASI DENGAN MEDIA PEMBELAJARAN PAPAN PINTAR BERHITUNG PADA ANAK USIA 6-7 TAHUN
Authors: Bopo Gaudensiana , Ngura Elisabeth Tantiana , Fono Yasinta Maria , Laksana Dek Ngurah Laba
Published: April 2024

Penelitian ini bertujuan untuk meningkatkan kemampuan numerasi dalam pembelajaran matematika dengan menggunakan media papan pintar berhitung bagi anak usia 6-7 tahun di Desa Nagerawe, Kecamatan Boawae, Kabupaten Nagekeo. Penelitian ini menggunakan penelitian tindakan kelas yang melibatkan 29 siswa kelas awal sebagai partisipan. Metode yang digunakan peneliti adalah; metode pengumpulan data menggunakan tes. Penelitian ini dilakukan dengan pra siklus dan siklus 1. Hasil penelitian menunjukkan bahwa penggunaan media papan pintar berhitung secara signifikan dapat meningkatkan kemampuan numerasi penjumlahan 1-20 pada siswa kelas awal. Penggunaan media papan pintar berhitung pada pembelajaran matematika dengan materi penjumlahan 1-20 dinyatakan meningkat setelah menggunakan media papan pintar dari pra siklus ke siklus 1 sebesar 10,69 % dan memperoleh skor rata-rata pra siklus sebesar 54,48% ke siklus 1 rata-rata sebesar 65,17% atau berada pada kategori cukup. Dari siklus I ke siklus II mengalami peningkatan rata-rata sebesar 80%. Sedangkan, secara klasikal terjadi peningkatan dari siklus I ke Siklus II yaitu sebesar 100% dari penetapan 75%. Hal ini mengindikasikan bahwa penggunaan media papan pintar berhitung sangat efektif dalam meningkatkan kemampuan numerasi pada anak usia 6-7 tahun.
PROFIL KUALITAS BERPIKIR INOVATIF GURU DI SEKOLAH MENENGAH ATAS
Authors: Wulandari Veni , Astuti Indri , Afandi
Published: April 2024

Pemikiran yang inovatif merupakan proses kognitif yang menjadi kompetensi penting dan merupakan kebutuhan yang harus dimiliki di abad ke 21 ini. Di bidang pendidikan berpikir inovatif dapat membantu guru dan siswa bisa dengan mudah beradaptasi pada kemajuan teknologi yang terus berkembang. Penelitian yang dilakukan ini memiliki tujuan untuk melihat kualitas berpikir inovatif guru di SMA Negeri 1 Kayan Hilir dengan menggunakan metode penelitian kuantitatif deskriptif. Instrumen yang dipergunakan yaitu soal angket sebanyak 19 soal yang terdiri dari 4 indikator yaitu guru mengamati, bertanya, mempunyai jaringan/ forum dalam hal mengembangkan diri dan guru melakukam eksperimen. Jumlah sampel dalam penelitian ini adalah 22 orang yang merupakan guru-guru di SMA Negeri 1 Kayan Hilir. Pengumpulan data melalui survey angket dianalisis menggunakan metode deskriptif kuantitatif dengan mengkonversikan data pada skala likert. Melalui penelitian yang dilakukan maka rata-rata kualitas berpikir inovatif yang diperoleh dari rata-rata seluruh indikator adalah 76,02. Kesimpulan yang diperoleh adalah kualitas berpikir inovatif guru di SMA Negeri 1 Kayan Hilir sudah baik (mean = 76,02).
A EDUCAÇÃO A DISTÂNCIA: A FORMAÇÃO DO PROFESSOR NO CONTEXTO DAS TECNOLOGIAS DIGITAIS DA INFORMAÇÃO E COMUNICAÇÃO E PRÁTICAS EMERGENTES
Authors: Lima Christiane Valêska Araújo Costa , Pereira Gisele Adriana Maciel
Published: April 2024

O presente artigo busca discutir e refletir sobre as inovações tecnológicas e práticas emergentes e seus reflexos, numa perspectiva didática e pedagógica, tendo em vista a compreensão das relações que se estabelecem entre a educação a distância  e as novas tecnologias da informação e comunicação, colocando em evidência as variáveis que interferem nas formas de uso mais intenso e maciço dessas tecnologias em processos formativos de professores. Trata-se, de uma pesquisa de cunho qualitativo, ancorada em uma pesquisa bibliográfica e exploratória, para tanto são abordados como conceitos limiares a educação a distância, as Tecnologias Digitais de Informação e Comunicação e a representatividade docente. Depreende-se do estudo que as tecnologias e práticas emergentes têm cumprido papel relevante na elaboração e definição de metodologias que muito contribuem para as tranformações no campo da educação e da educação a distância em particular. Não obstante, estas não podem ser analisadas apartadas dos sujeitos, da instituições e dos contextos em que estão inseridas, pois quando estas não são potencializadas para garantir o máximo desenvolvimento das potencialidades humanas de forma democrática, elas acabam por ampliar as desigualdades se convertendo em instrumentos de legitimação de inequidades e exacerbação das diferenças, ou mesmo engessamento de práticas já sedimentadas incapazes de promover a autonomia e emancipação humana.
Challenges Experienced by Physically Challenged Learners in Practical Physical Education Classes in South Africa: A Systematic Analysis
Authors: Thekethe Dikeledi B. , Ogbonnaya Ijeoma C.
Published: April 2024

This paper, framed within the interpretivism theory, argued that government, stakeholders, and policymakers could foster and promote policy advocacy to address the challenges militating against the participation of physically challenged learners (PCLs) in practical physical education (PE) classes. Despite the noticeable need for physical activities in the lives of PCLs, there are growing concerns that learners in physical education classes still face many challenges in practical classes. The research was a systematic review of literature that identified studies that focused on the challenges that PCLs experience in practical physical education classes. Data was gathered from a collection of relevant articles as well as 20 publications that were critically reviewed. Only ten publications were found to meet the inclusion criteria. As a result, four main themes emerged from the data as thematic analysis was adopted. The findings revealed that PCLs frequently encounter challenges such as inaccessible equipment, poor social support, the PE curriculum/programme, and a lack of teachers training in practical physical education classes, which can limit their ability to engage and fully participate in PE practical classes. The study contributed to the body of physical education studies by providing a framework for a more integrated Physical Education for Physically Challenged Learners (PCLs), which could be implemented all around the world. It recommends, among others, that the members of the executive councils, school management teams and policymakers should work together by providing schools with accessible equipment and strong social support for PCLs to feel less isolated and more supported. This study concludes that exploring these challenges and developing coping strategies can help to ensure that PCLs can participate and benefit from PE practical classes.

Keywords: Physical Education, Physically Challenged Learners, Practical Classes, Systematic Analysis
La
sinestopía
del olfato: estatus factual de los olores en
El sueño de África
de Javier Reverte
Authors: LAFFITTE IRENE DONATE
Published: April 2024

El concepto de
sinestopía
vincula la percepción sensorial alojada en las descripciones con determinados espacios geográficos. Se profundiza en el estudio de estas descripciones según las pautas suministradas por las teorías de la modalidad epistémica y la evidencialidad. Se ilustra en todo momento el concepto de
sinestopía
revisando las descripciones olfativas contenidas en el relato de viaje
El sueño de África
(1996) de Javier Reverte con el fin de analizar su estatus factual. El estudio de la modalidad epistémica del lenguaje olfativo de Reverte muestra el grado de certidumbre que el viajero asume respecto a la factualidad de los olores y de los lugares que describe, dato que contribuye a configurar el carácter no ficcional del relato de viaje.
EVALUATION OF THE PERFORMANCE OF MULTI-GNSS ADVANCED ORBIT AND CLOCK AUGMENTATION – PRECISE POINT POSITIONING (MADOCA-PPP) IN JAPAN REGION
Authors: Pırtı Atınç
Published: April 2024

For users of Precise Point Positioning (PPP), Multi-GNSS Advanced Orbit and Clock Augmentation PPP signals provide corrective data. When using the PPP approach and/or PPP-Ambiguity Resolution (AR) method, the QZSS signal provides globally applicable error corrections on satellite orbit, clock offset, and code/phase biases. In addition, from FY2024, as a part of the MADOCA-PPP technology demonstration, wide-area ionospheric correction data will be provided for the Asia-Oceania region. A software estimator of precise satellite information developed by JAXA, Multi-GNSS Advanced Demonstration Tool for Orbit and Clock Analysis (MADOCA), allows u-blox CO99-ZED-F9P and MSJ 3008-GM4-QZS utilizing MADOCA-PPP to be used in GNSS applications that need sub-decimetre precision but don’t have to be expensive. Errors caused by positioning satellites are computed by using observation data from domestic and overseas GNSS monitoring station networks such as IGS and MIRAI, and obtained correction data is transmitted from QZSS signal to provide highly precise positioning augmentation services that can be used in the Asia-Oceania Region. Users may utilize the PPP technique for high-precision locating by employing a GNSS receiver that supports the QZSS signals. This paper describes an experiment carried out with the static method to combine GPS, GLONASS, and QZSS signals in the project site (ISHI, USUD and MIZU stations in Japan). This paper examines the GPS/GLONASS/QZSS obtainable accuracy. These obtained results indicate that integrating GPS system with GLONASS and QZSS is favoured for surveying applications. It appears that integrating GPS/GLONASS/QZSS (MADOCA precise ephemeris file) static measurements in the study area between 0–4 millimetres accuracy can be guaranteed on all occasions.
ACCURACY ASSESSMENT OF THE EFFECT OF DIFFERENT FEATURE DESCRIPTORS ON THE AUTOMATIC CO-REGISTRATION OF OVERLAPPING IMAGES
Authors: Ajayi Oluibukun Gbenga , Nwadialor Ifeanyi Jonathan
Published: April 2024

This research seeks to assess the effect of different selected feature descriptors on the accuracy of an automatic image registration scheme. Three different feature descriptors were selected based on their peculiar characteristics, and implemented in the process of developing the image registration scheme. These feature descriptors (Modified Harris and Stephens corner detector (MHCD), the Scale Invariant Feature Transform (SIFT) and the Speeded Up Robust Feature (SURF)) were used to automatically extract the conjugate points common to the overlapping image pairs used for the registration. Random Sampling Consensus (RANSAC) algorithm was used to exclude outliers and to fit the matched correspondences, Sum of Absolute Differences (SAD) which is a correlation-based feature matching metric was used for the feature match, while projective transformation function was used for the computation of the transformation matrix (T). The obtained overall result proved that the SURF algorithm outperforms the other two feature descriptors with an accuracy measure of -0.0009 pixels, while SIFT with a cumulative signed distance of 0.0328 pixels also proved to be more accurate than MHCD with a cumulative signed distance of 0.0457 pixels. The findings affirmed the importance of choosing the right feature descriptor in the overall accuracy of an automatic image registration scheme.
STABILITY ANALYSIS FOR HETEROGENEOUS TRAFFIC FLOW WITH LANE-CHANGE DISTURBANCE
Authors: Li Hao , Pu Yun , Chen Lingjuan , Luo Xiaoyu
Published: April 2024

Stability analysis and benefit estimation have substantial implications for lane-change decision-making to reduce delay and variation. Connected platoons drive with minor headway to increase capacity, whereas dividing or reforming platoons significantly impacts traveling efficiency. Therefore, this article focuses on the instability of the platoon caused by an en-route lane-change. Construction of platoon forming, combination rules, and car-following models for various vehicle types are presented to describe driving behaviours. Then, a velocity adjustment and a model for lane-change preparation and recovery are proposed. In addition, a group of stability recognition indexes and related stability evaluation factors are presented. Experiments involving numerical comparisons of the proposed factors are conducted to demonstrate the propagation properties of the instability and reveal the fluctuation degree. The variation duration, velocity variation range, and total delay are the primary indicators for evaluating lane-change feasibility. The models and findings can be applied effectively in practice to determine the optimal time and location for en-route lane-change and to assist with traffic management and lane selection at the entrance.
Measurements of Titan’s Stratospheric Winds during the 2009 Equinox with the eSMA
Authors: Light Siobhan , Gurwell Mark , Thelen Alexander , Lombardo Nicholas A , Nixon Conor
Published: April 2024

Saturn’s moon Titan possesses stratospheric zonal winds that places it among a sparse class of planetary bodies known to have superrotation in their atmospheres. Few measurements have been made of these speeds in the upper stratosphere, leaving their seasonal variations still not well understood. We examined observations made with the extended Submillimeter Array in 2009 March (L

s
= 355°) and 2010 February (L

s
= 5°), shortly before and after Titan's northern spring equinox. Cassini observations and atmospheric models find equinoctial periods to be especially dynamic. Zonal wind calculations, derived from the Doppler frequency shift of CH3CN near 349.4 GHz, yielded speeds of 128 ± 27 m s−1 in 2009 and 209 ± 48 m s−1 in 2010. We estimated the measured emission to originate from vertical altitudes of

336

−
88

+
112

km, equivalent to pressures of

3.8

−
3.4

+
19.2

Pa, commensurate with Titan’s upper stratosphere/lower mesosphere. This suggests a possible increase in zonal speeds during this period. The results are then compared to those from previous Cassini-inferred and direct-interferometric observations of winds, as well as general circulation model simulations, to form a more complete picture of the seasonal cycle of stratospheric zonal winds.
Some results for a supercritical Schrödinger-Poisson type system with $ (p, q) $-Laplacian
Authors: Liang Hui , Song Yueqiang , Yang Baoling
Published: April 2024

In this work, we focus our attention on the existence of nontrivial solutions to the following supercritical Schrödinger-Poisson type system with $ (p, q) $-Laplacian:

   \begin{document}$ \begin{equation*} \begin{cases} -\Delta_{p}u-\Delta_{q}u+\phi|u|^{q-2} u = f\left(x, u\right)+\mu|u|^{s-2} u & \text { in } \Omega, \\ -\Delta \phi = |u|^q & \text { in } \Omega, \\ u = \phi = 0 & \text { on } \partial \Omega, \end{cases} \end{equation*} $\end{document}

where $ \Omega \subset \mathbb{R}^N $ is a bounded smooth domain, $ \mu > 0, N > 1 $, and $ -\Delta_{{\wp}}\varphi = div(|\nabla\varphi|^{{\wp}-2} \nabla\varphi) $, with $ {\wp}\in \{p, q\} $, is the homogeneous $ {\wp} $-Laplacian. $ 1 < p < q < \frac{q^*}{2} $, $ q^*: = \frac{Nq}{N-q} < s $, and $ q^* $ is the critical exponent to $ q $. The proof is accomplished by the Moser iterative method, the mountain pass theorem, and the truncation technique. Furthermore, the $ (p, q) $-Laplacian and the supercritical term appear simultaneously, which is the main innovation and difficulty of this paper.
Optimizing Blood Glucose Regulation in Type 1 Diabetes Patients via Genetic Algorithm-Based Fuzzy Logic Controller Considering Substantial Meal Protocol
Authors: Ndakara Abubakar Isah , Essabbar Moad , Saikouk Hajar
Published: April 2024

Effective management of blood glucose levels in individuals with type 1 diabetes, especially after meals, is crucial for diabetes care. Artificial pancreas systems (APS) perform automated insulin delivery in subjects with type 1 diabetes mellitus (T1DM). In this study, an optimized fuzzy logic controller was designed to achieve a euglycemic range after a substantial meal intake. All in silico simulations were performed using the MATLAB/Simulink environment, leveraging control variability grid analysis (CVGA), and the performance of the controller was evaluated. The proposed controller is based on a fuzzy-logic control law designed in three stages. First, a nonlinear framework of the glucose-insulin regulatory system was identified based on the heavy meal protocol of three patients given as follows: for subject ID 117-1, a total of 295 gCHO; for subject ID 126-1, 236 gCHO; and subject ID 128-1, 394 gCHO over a day. Then, an iterative tree structure was employed to establish a stabilizing control rule for insulin delivery, integrating inputs from two Mamdani Fuzzy Inference System (FIS) objects. Finally, a genetic algorithm refines the control system by fine-tuning the uncertainty of the fuzzy membership functions. Two scenarios were considered for three patients to assess the performance of the proposed controller. The results indicated its effectiveness under various conditions, achieving a time in the range of 61.25%, 71% and 61.10% respectively for the three subjects. The obtained results are analyzed and compared with IMC and multi-objective output feedback controllers. The findings of the study reveal that the proposed controller shows promising advancements in tailored strategies for type 1 diabetes patients, outperforming the other controllers in terms of blood glucose regulation.
The Effect of Twisted Wire Configuration on the Stability of External Fixator: A Biomechanical Study
Authors: Najim Alaa A. , Hamandi Sadiq J. , Alzubaidi Ahmed
Published: April 2024

The Ilizarov fixator is a type of external fixator that is used to treat patients who have suffered injuries from accidents, bone shortening, or nonunion of the bone. The principle behind the Ilizarov fixator is that thin wires (called Kirschner wires) are used to support the bones and connect them to framed rings. Before being fastened to the rings, the wires are tensioned and drilled through the bones. This study suggests using a new parallel wires configuration at the same level on the same ring and two revised versions, which are divergent and convergent models, and compare them with standard wires, 60 angle wires model. All models were designed using SolidWorks, a computer-aided design (CAD) software, and then analyzed in four conditions (axial compression, medial bending, posterior bending, and torsion) with Finite Element Analysis (FEA) using Ansys Workbench 2020 R2. Mechanical testing was conducted to validate the FEA results, A simple model consisting of a single ring, two K-wires, and polylactic acid (PLA) cylinders was utilized in a tensile test. It has been concluded from the results that the parallel model and its improvement have higher stiffness to axial compression, medial bending, and torsion, but a lower posterior bending stiffness, except the divergent model with 8-hole separation which has a relatively acceptable stiffness for posterior bending.
An Optimized Effective Authentication Process for E-Health Application
Authors: Choura Hedi , Chaabane Faten , Baklouti Mouna , Frikha Tarek
Published: April 2024

Because of the availability of more than an actor and a wireless component in an e-health application, providing more security and safety to users of this type of applications is expected. Moreover, ensuring protection of data user available or shared within different services from any security attack becomes an important requirement. In this paper, we are interested essentially in the authentication process, and we propose an improved Landmarkbased algorithm as a tool to extract, firstly, key features from analysed faces, and hence to accelerate the authentication operation. The suggested approach beats other state-of-the-art works in terms of accuracy and speed-up attaining time execution constraint, according to experimental evaluations.
The Development and Study of an Electromechanical Converter for an Electro-Hydraulic Power Amplifier of a Servo-Hydraulic Drive
Authors: Gandzha Sergey , Neustroev Nikolay , Sogrin Andrey , Korobatov Denis , Ardashev Dmitry V. , Dadashov Ramil
Published: April 2024

This paper presents design solutions in the development of an electro-hydraulic power amplifier (EHPA) of a servo-hydraulic drive with hydrostatic guides. The work studies the characteristics and develops fundamental solutions to design elements and the general configuration of the EHPA, which is part of the servo-hydraulic drive. The paper analyzes the device, operating principles, and basic requirements for EHPAs. A digital model is built and a basic version of an electromechanical converter (EMC) is tested to assess its electromagnetic and thermal state. As a result of the work, the authors determined and justified the design of the main components of the EMC for the EHPA, developed a digital model for the EMС with permanent-magnet excitation, analyzed its electromagnetic and thermal state, and developed design documentation.
Specifics of the Planning of Additive Manufacturing Processes
Authors: Aliyev Rezo
Published: April 2024

This paper describes a new approach for planning additive manufacturing (AM) technology. Based on the technological heredity between the stages of the process chain, an optimisation method is proposed that makes it possible to minimise manufacturing costs under consideration of the quality requirements.
The Adsorption of Heavy Metal Ions
Authors: Yusubov Fakhraddin , Mirbabayev Miryusif , Talibov Gulahmad , Aliyev Ilham , Valiyeva Govhar
Published: April 2024

The aim of the study is to research of the adsorption properties of heavy metal ions Pb2+, Cd2+ and Ni2+ from industrial wastewater. For the adsorption of heavy metal ions, natural clinoptilolite was used, which belongs to the Ai-Dag deposit of the Tovuz-Kazakh region of Azerbaijan. Isotherms and kinetic curves of adsorption of heavy metal ions Pb2+, Cd2+ and Ni2+ were determined. The dependence of the adsorption of heavy metal ions on the pH value is also shown. It was revealed that the separation process proceeds more intensively at pH values ​​of 5-6. It has been established that the maximum adsorption capacity of the clinoptilolite adsorbent for adsorption of Pb2+, Cd 2+ and Ni2+ ions is 7.5, 6.7 and 5.9 mmol/g, respectively.
Investigation for Multi-Layer CuAl8 and Multi-Material (CuAl8-Mild Steel) Deposition via WAAM Process
Authors: Shah Abid , Aliyev Rezo , Zeidler Henning , Krinke Stefan
Published: April 2024

Wire arc additive manufacturing (WAAM) according to ISO/ASTM 52900:2021 is a widely known additive manufacturing process to produce a new 3D part or repair a damaged metal part. Copper-based alloy, i.e., CuAl8, is widely used to repair marine structures and to make bearing overlays due to its excellent corrosion and wear resistance properties. This paper will give an insight into the multi-layer deposition of CuAl8 at different substrate orientations. Furthermore, multi-material deposition, i.e., CuAl8 and mild steel, is investigated, which can help industries to combine the features of both materials and lead to the development of functionally graded materials.
Methodology for Assessing the Degree of Aging Overhead Power Transmission Lines of EES
Authors: Muradaliyev Aydin
Published: April 2024

The main objects of the EES, the service life of which exceeded the standard value, are increasingly beginning to determine the efficiency of work every year. This manifested in an increase in the number of automatic emergency shutdowns, the number and complexity of emergency-hazardous defects. Organization of operation, maintenance and repair of these facilities recommended carried out according to their technical condition. And since the technical condition determines the reliability and safety of the object, it is therefore recommended to take these properties into account more fully. These recommendations in the EES carried out at a high quality level, intuitively, according to operating experience.In this article, as distributed objects of continuous operation, overhead power transmission lines (OPTL) with a voltage of 110 kV and higher, the service life of which exceeds the standard value, are considered. The issues of quantifying the degree of significance of the aging problem for a set OPTL, their classification and methodology for assessing the difference in the degree of aging when classifying them according to given types of characteristics are considered. The methodology and algorithm of methodological support for the management of the EES and network enterprises during the organization of operation, maintenance and repair, been developed.
Integrin αvβ3 Limits Cytokine Production by Plasmacytoid Dendritic Cells and Restricts TLR-Driven Autoimmunity
Authors: Lorant Alina K , Yoshida Anna E , Gilbertson Emily A , Chu Talyn , Stefani Caroline , Acharya Mridu , Hamerman Jessica A , Lacy-Hulbert Adam
Published: April 2024

Plasmacytoid dendritic cells (pDCs) are strongly implicated as a major source of IFN-I in systemic lupus erythematosus (SLE), triggered through TLR-mediated recognition of nucleic acids released from dying cells. However, relatively little is known about how TLR signaling and IFN-I production are regulated in pDCs. In this article, we describe a role for integrin αvβ3 in regulating TLR responses and IFN-I production by pDCs in mouse models. We show that αv and β3-knockout pDCs produce more IFN-I and inflammatory cytokines than controls when stimulated through TLR7 and TLR9 in vitro and in vivo. Increased cytokine production was associated with delayed acidification of endosomes containing TLR ligands, reduced LC3 conjugation, and increased TLR signaling. This dysregulated TLR signaling results in activation of B cells and promotes germinal center (GC) B cell and plasma cell expansion. Furthermore, in a mouse model of TLR7-driven lupus-like disease, deletion of αvβ3 from pDCs causes accelerated autoantibody production and pathology. We therefore identify a pDC-intrinsic role for αvβ3 in regulating TLR signaling and preventing activation of autoreactive B cells. Because αvβ3 serves as a receptor for apoptotic cells and cell debris, we hypothesize that this regulatory mechanism provides important contextual cues to pDCs and functions to limit responses to self-derived nucleic acids.
A study on tumor necrosis factor-α single nucleotide polymorphisms and psoriasis vulgaris in Vietnam
Authors: Ngo Minh Vinh , Lý Thiên Phúc , Nguyen Trong Hao , Nguyen Hoang Chuong
Published: April 2024

This study aims to evaluate the association between tumor necrosis factor-α (TNF–α) single nucleotide polymorphisms and psoriasis vulgaris. This cross-sectional study involved 140 Vietnamese patients of Kinh ethnicity diagnosed with psoriasis vulgaris. The diagnosis of psoriasis vulgaris was based on clinical signs and symptoms. We used Sanger sequencing to analyze two SNPs rs1799964 and rs1799724. Data were analyzed by SPSS 25. SNP rs1799964 has the highest rate of TT genotype at 62.1%, more than double the heterozygous TC genotype at 30%, CC genotype has the lowest rate at 7.9%. CC genotype of SNP rs1799724 accounted for 90% and no homozygous genotype TT was detected. No statistically significant association was found between both SNPs and clinical features (p >0.05). The Psoriasis Area and Severity Index (PASI) was significantly lower in patients with variant alleles (P =0.021). Our data show a significant negative association between SNPs variant alleles and disease’s severity. Studies with larger sample sizes and more biochemical indices may help identify reliably predictive markers for these SNPs.
Comparison between dutasteride and finasteride in hair regrowth and reversal of miniaturization in male and female androgenetic alopecia: a systematic review
Authors: Almudaimeegh Almuntaserbellah , AlMutairi Hanadi , AlTassan Fatimah , AlQuraishi Yomna , Nagshabandi Khalid Nabil
Published: April 2024

Nowadays androgenetic alopecia (AGA) has become a common concern of affected subjects of both sexes. Finasteride is approved by the Food and Drug Administration for the treatment of male AGA. There is no clear evidence to support the use of dutasteride in male AGA. In female AGA, the effectiveness of dutasteride and finasteride is still under debate, and there is no clear evidence to use any of them in female AGA. A systematic review was conducted to compare between dutasteride and finasteride in treating both male and female AGA, and their efficacy, safety, side effects with effective dosage. The review was done using several databases including: PubMed, Ovid Medline, Google Scholar, and Cochrane using the following search terms/keywords: "Dutasteride" AND "Finasteride" AND "Male pattern hair loss" AND "Female pattern hair loss" AND "Efficacy", "Tolerability" AND "Side effects" AND "Comparison". To search for articles related to efficacy, tolerability, side effects, used doses of dutasteride and finasteride in the treatment of male and female AGA. The review encompassed a total of nine studies. Four randomized controlled trials, one single-arm trial, two prospective cohorts, and two retrospective cohort studies. Seven studies exclusively enrolled male participants, while only two included female participants. All groups receiving various doses of dutasteride and finasteride exhibited a significant increase in hair count compared to the placebo group. Notably, dutasteride (0.5 mg) and dutasteride (2.5 mg) were significantly more effective than finasteride (1 mg) in increasing hair counts. Furthermore, no significant difference in adverse events was observed between finasteride and dutasteride. Dutasteride is more potent than finasteride in treating AGA in both males and females. All the adverse events between finasteride and dutasteride were comparable.
Giant clear cell acanthoma: a case report and a review of the literature
Authors: Cucchiara Antonio Luca , Sonego Benedetta , Sola Simona , Massone Cesare
Published: April 2024

Clear cell acanthoma (CCA) is an uncommon benign epidermal tumor of unknown origin and etiology. It is often solitary, and the presence of multiple CCAs in the same individual is rare. Typically, it presents as a slowly growing plaque or nodule located on the legs with a peripheral scaling collarette. Diagnosis is primarily based on clinical and histopathological findings, with dermoscopy enhancing diagnostic accuracy. The differential diagnosis includes various skin tumors and inflammatory dermatoses. The preferred treatment is surgical excision, as these lesions do not regress spontaneously. We describe a case of a large CCA on the right thigh associated with multiple small nodular lesions scattered across the legs.
Underrepresentation of atopic dermatitis publications in pediatric journals: a bibliometric analysis
Authors: Zlakishvili Barak , Weissmann Sarah , Horev Amir
Published: April 2024

Extensive research has been published on atopic dermatitis (AD), a prevalent skin condition amongst pediatricians. To assess the pediatric representation in the most cited literature on AD, using bibliometric analysis. Web of Science citation indexing database was used to identify publications with "atopic" and "dermatitis" or "eczema" in their title. Results were ranked by their Annual citation(Ac) and refined to the 100 topmost cited articles in the non-refined pediatric category and the top five journals in the categories of general medicine, dermatology, and pediatrics, by impact factor. 28,360 publications were retrieved. The metrics were significantly higher in dermatology, compared to pediatric and general categories [(RTC = 0.899, p < .001), (RAC = 0.795, p < .001), (Rusage count = 0.639, p < .001)] and [(RTC = 0.417, p < .001), (RAC = 0.392, p < .001), (Rusage count = 0.279, p < .001)]. This analysis is the first to highlight the underrepresentation of AD publications in the pediatric literature, which might impact the clinicians' and patients' level of care and AD annual societal expenditure.
Bayesian Network Model and Causal Analysis of Ship Collisions in
Zhejiang Coastal Waters
Authors: Tian Yanfei , Qiao Hui , Hua Lin , Ai Wanzheng
Published: April 2024

For taking counter measures in advance to prevent accidental risks, it is of
significance to explore the causes and evolutionary mechanism of ship
collisions. This article collects 70 ship collision accidents in Zhejiang
coastal waters, where 60 cases are used for modeling while 10 cases are used for
verification (testing). By analyzing influencing factors (IFs) and causal chains
of accidents, a Bayesian network (BN) model with 19 causal nodes and 1
consequential node is constructed. Parameters of the BN model, namely the
conditional probability tables (CPTs), are determined by mathematical statistics
methods and Bayesian formulas. Regarding each testing case, the BN model’s
prediction on probability of occurrence is above 80% (approaching 100% indicates
the certainty of occurrence), which verifies the availability of the model.
Causal analysis based on the backward reasoning process shows that H (Human
error) is the main IF resulting in ship collisions. The causal chain that
maximizes the likelihood of an accident occurring is: H1 (improper lookout) → H4
(underestimation of collision) → H7 (failure of taking effective
collision-avoidance measures) → H (human error) → C (ship collision). By
implementing sensitivity analysis process, key IFs of ship collisions are found
and are ranked as: H9 (improper emergency handling), H7 (failure of taking
effective collision-avoidance measures), H6 (without using safe speed), H4
(underestimation of collision), H1 (improper lookout), H3 (nonstandard duty), H8
(failure of fulfilling “giving way” responsibility), H5 (unaware of target
ships), and H2 (crew incompetence). Among them, H9 (improper emergency handling)
and H7 (failure to take effective collision-avoidance measures) have relatively
high sensitivity and greater impact on collision accidents. Results show that
the BN model can be used to analyze the causes of ship collisions in Zhejiang
coastal waters and to predict the probability of occurrence of accidents. The
research will provide theoretical and practical support for exploring the causes
and revealing the evolutionary mechanism of accidents, and for taking targeted
risk control measures to prevent future accidents.
Copper Alloy, Brazing Filler Metal, 52.5Cu - 38Mn - 9.5Ni, 1615 to 1700 °F (879 to 927 °C) Solidus-Liquidus Range
Authors:   AMS D Nonferrous Alloys Committee
Published: April 2024

This specification covers a copper alloy in the form of wire, rod, sheet, strip, foil, and powder and a viscous mixture (paste) of powder in a suitable binder (see 8.6).
A curiosa proposta de transferência da jurisdição para o Ministério Público: reflexões críticas sobre a interpretação alternativa do artigo 385 do CPP
Authors: Rocha Ronan
Published: April 2024

The article 385 of the Criminal Procedure Code authorizes the judge to hand down a conviction in unconditional or conditional criminal actions, even if the Public Prosecutor’s Office has given its opinion in favor of acquittal. This legal command has been increasingly criticized by some scholars, who support an alternative interpretation according to which the judge could not hand down a conviction after the Public Prosecutor’s Office has given its opinion in favor of acquittal. This article analyzes the main arguments put forward by the defenders of the thesis in question. It then presents arguments that have been disregarded in the debate, both constitutionally and legally. Finally, it concludes that the thesis analyzed lacks legal support