bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinicopathological Characteristics and the Relationship between Histological Grade with Luminal B Breast Cancer in RSUP Mohammad Hoesin within 2014-2016
Authors: Awaliah Reihan Putri , Dewi Citra , Puspita Rasyid Riana Sari
Published: April 2022

BackgroundBreast carcinoma is the second highest malignant disease that causes death in Indonesia with 58,256 new cases in 2018. LuminalB has more aggressive clinical behavior and is considered as having unfavorable prognosis. This study aimed to determine theclinicopathological characteristics and the relationship histological grade with breast carcinoma subtype molecular luminal B.MethodsThis is a descriptive analytic study with cross sectional design using secondary data of breast carcinoma patients registered atRSUP Mohammad Hoesin Palembang during the period of January 1st, 2014 to December 31st, 2016.ResultsFrom 903 breast carcinoma patients in Mohammad Hoesin Hospital Palembang during 2014 to 2016, 43.63% had luminal Bmolecular subtype. The highest incidence and prevalence washappened in year 2016, whichwere 4.7 and 4.4 per 10 breastcarcinoma patients, respectively. The majority of breast carcinoma of luminal B molecular subtype occurs in the group of patientsaged ≥40 years (81.7%), female (98.7%), Malay race (100%), marital status (98.8%), housewives (68.3%), histopathologicalcarcinoma of invasive non-specific type (75.9%), high grade/ grade III (63.7%), localized (60.6%), no metastases (60.0%), rightsided tumor laterality (50.8%) and with negative HER2 (65.2%). There was a significant relationship between the histopathologicalgrade and breast carcinoma luminal B molecular subtype (p=0.009).ConclusionThe incident of breast carcinoma molecular subtype luminal B at Mohammad Hoesin Hospital Palembang has increased in the lastthree years with the poor clinicopathological characteristics.
Granulomatous Mastitis: A Diagnostic Challenge
Authors: Dewi Citra , Amalia Ella , Kurniawati Nyiayu Fauziah , Maria Ulfa, Maria Ulfa, , Pratama Eka Putra , Murti Krisna
Published: April 2022

BackgroundGranulomatous mastitis (GM) is often found in reproductive-age women. These patients are treated by the administration ofantituberculosis drugs. It is difficult to determine the exact cause of GM cytologically and histopathologically. Various etiologies i.e.,tuberculosis, sarcoidosis, foreign bodies and immunological diseases may provide granulomatous inflammation features in thetissue. High-sensitivity tests such as PCR can help to detect the presence of Mycobacterium tuberculosis (MT) as one of possibleetiologic agent. Accurate diagnosis will improve the treatment quality thus a better quality of life. The aim of this study was todetermine whether the granulomatous mastitis patients who referred to the Department of Anatomic Pathology Faculty of MedicineUniversitas Sriwijaya/Dr. Moh. Hoesin Palembang Hospital were caused by MT.MethodsA descriptive observational study was performed. Thirty paraffin blocks of GM patients during the period of 1st October 2018 to 29thSeptember 2020 were collected. DNAs were extracted from tissue scrapings of the slides. Then, PCR analysis was conducted usinga specific primer IS6110 with around 200 bp PCR product.ResultsThe mean age of the patients was 40.8 years (range: 23-67 years). There were six samples (20%) of GM produced the expectedamplicon. However, only three of six samples morphologically consistent with tuberculosis.ConclusionGranulomatous inflammatory reactions in the breast are not only caused by tuberculosis. Further study is needed to determine theexact cause of this lesion. Despite high costs, PCR examination may become an alternative approach in determining the etiology ofGM.
Leadership Through Organizational High Reliability During the COVID-19 Pandemic — Navy Medicine’s Experience
Authors: Gillingham Bruce , Applehans Denver
Published: April 2022

The U.S. Navy medical establishment, also known as Navy Medicine, began working toward operating as a high-reliability organization in 2014. The results have paid dividends in the current COVID-19 pandemic. This article provides a case study of the use of high-reliability organization (HRO) principles to support continued health of U.S. Navy and U.S. Marine Corps operational forces in a pandemic. The authors provide examples of how adherence to the five traits of an HRO allowed Navy Medicine to be agile and responsive and ultimately to prevent significant disruption to Naval operations worldwide during the pandemic.
Siembra directa de semillas de Ochroma pyramidale (Cav. ex Lam.) aplicando dos densidades para la recuperación de suelos degradados por la actividad minera en la Amazonía peruana
Authors: Rosales-Solórzano Emer , Huayllani Huamani Pablo , Huanaco-Huanca Raul
Published: April 2022

El estudio tuvo como objetivo evaluar el desarrollo por siembra directa de semillas de Ochroma pyramidale (Cav.  ex Lam.)  para la remediación de las áreas degradadas por la actividad minera en el sector de Virgen de la Candelaria, distrito de Inambari del departamento de Madre de Dios. El método aplicado fue un diseño experimental, del tipo aplicado cuantitativo y explicativo. El proceso de siembra constó de cuatro fases: instalación de parcelas, marcación, siembra de las semillas y fertilización. El diseño experimental instalado fue de 3 × 2. Se realizó un Análisis de Varianza (ANOVA), con una prueba de Fisher a un nivel de significancia α 0,05. El crecimiento en altura promedio fue de 18,98 mm y su germinación 43,98%, que comparado las dos densidades de siembra de 1 m × 2 m y 2 m × 4 m resultó ser diferente estadísticamente (α = 0,05). Así mismo la mortalidad promedio encontrada fue 52,05% es decir ligeramente alto, no habiendo diferencia estadística entre densidades de siembra.
Family Independence in Implementing Family Health Tasks to Reduce the Risk of Fall in East Pentadio Village, Gorontalo Regency
Authors: Febriyona Rona , Yunus Pipin , Laukum Nadia M. , Ismail Deisy Cintiya , Kune Rian Y.
Published: April 2022

Independence is a condition in which a person who has the will and ability tries to fulfill the demands of his life in a legal, reasonable and responsible manner for everything he does. The family has a very big role in the safety of the elderly, especially in preventing falls. The purpose of this study is that the public can find out the importance of family independence in carrying out family health tasks to reduce the risk of falling. There are five family health tasks that must be considered, including being able to recognize family health problems, being able to make appropriate action decisions, being able to provide care to sick family members, being able to modify the environment, and being able to take advantage of public health service facilities. It can be concluded that after counseling the family and the elderly have understood the task of family health, once a day the family teaches tandem walking to the elderly to reduce the risk of falling in the elderly in Pentadio Timur Village, Gorontalo Regency
Assessment of selected muscles reactivity in the lower spinal segment
Authors: Chojowski Kacper , Strzelczyk Kamila , Kuszewski Michał
Published: April 2022

Background: Lumbar spine pain is now a common affliction. In 90% of cases, the pain is of ambiguous and multicausal etiology, described as non-specific lower back pain (NLBP). Various models of this dysfunction were examined. The most popular model presents the pain as a result of an insult and secondary to changes in tension and lumbar muscles degeneration. There is no unequivocal solution concerning the cause of lumbar spine pain in the literature.
Aim of the study: To examine the differences in muscles reactivity in the lumbar region in cases who suffer from lumbar spine pain in comparison to otherwise healthy controls.
Material and methods: In total, 50 participants (24 men and 26 women) aged 18–45, including 24 people with pain, and 26 without ailments were included in the study. The visual analogue scale was used to measure pain intensity. The participants were assessed to determine the reactivity of the soft tissues of the lumbar part of the body. Selected muscles of this area were examined using a myotonometer, which shows five parameters relevant to viscoelastic tissues.
Results: There were significant differences in the level of the pain (p<0.001), hypokinesia of the left abdominal rectus (p<0.05), asymmetry indicators for the creep parameter of the erector spinalis and abdominal external oblique muscle, and the stiffness of abdominal rectus (p<0.05). No significant differences for the remaining parameters were found.
Conclusions: Tissue reactivity of selected muscles of the lumbar spine shows slight differences because of pain afflictions occurring in this area.
Industry of Bosnia and Herzegovina within Industry 4.0
Authors: Karabegović Isak , Bičo Ćar Mirha , Šestić Munira , Stupar Savo , Husak Ermin , Karabegović Edina , Mahmić Mehmed , Isić Safet , Vojić Samir , Banjanović-Mehmedović Lejla , Buljan Stipo , Lemeš Samir , Uzunović-Zaimović Nermina
Published: April 2022

Currently, the world is facing major changes. Research and development of innovations in new technologies, the rapid pace of implementation of these innovations and especially digitization and automation, play a major role in shaping the future world. Technological innovations promise the transformation of the world we live in all its dimensions. However, in order for the benefits of innovation to be adequately exploited, it is necessary for us as a society to adapt to the coming changes. We must also keep in mind that these changes come at a time previously marked by uncertainty, turbulent changes and hyper competitiveness. The development and implementation of new technologies in business is motivated by a number of technical and economic reasons: improving the quality of finished products (machining, etc.), increasing productivity and reducing the share of work (assembly process), increasing the degree of homogeneity of product quality in all production processes related to the application of robotic technology, increasing the level of safety, reducing labor engagement in routine and reproducible processes, minimizing total production costs and maintenance costs of the device in the production process, all with the purpose of adequate responses to competition challenges and increasingly stringent customer requirements. Although the concept of Industry 4.0 is already widely used in developed countries, it is a relatively new concept in the Western Balkans, including Bosnia and Herzegovina. Most company managers understand the benefits of "smart" production and are familiar with new trends in the industry, intend to gradually introduce smart solutions, methods and technologies, and only a small number of companies in Bosnia and Herzegovina currently implement the concept of Industry 4.0. The paper presents the results of research on the application of Industry 4.0 technologies in all branches of the economy in Bosnia and Herzegovina and especially the representation of Industry 4.0 in small, medium and large enterprises. Detection of awareness of certain groups about the concepts of Industry 4.0 was performed, and the research method itself is based on an online survey.
Identificação de Pesquisas e Análise de Algoritmos de Clusterização para a Descoberta de Perfis de Engajamento
Authors: Oliveira Pamella Letícia Silva de , Rodrigues Rodrigo Lins , Ramos Jorge Luis Cavalcanti , Silva João Carlos Sedraz
Published: April 2022

A adoção da Educação a Distância (EAD) é uma tendência que vem ganhando espaço no campo educacional. O número de pessoas que optam por esta modalidade de ensino vem crescendo. Vantagens como flexibilização do horário, diversidade de acesso geográfico e uso de tecnologias como meio de acesso proporcionam um aumento de adesão. Apesar destes benefícios que são oferecidos por meio da modalidade E-learning (Ensino Eletrônico) e das ferramentas de estudo, como LMS (Sistema de Gestão de Aprendizagem), as instituições ainda enfrentam altos índices de evasão e baixo número de concluintes. Pesquisas mostram uma forte ligação entre o engajamento dos alunos e o desempenho acadêmico, o que requer dos gestores e pesquisadores em educação mais atenção nos fatores que influenciam os níveis de engajamento dos alunos ao longo do curso, em vez de apenas considerar a taxa de conclusão. Neste sentido, este trabalho teve o objetivo de entender a relação entre os níveis de engajamento com o desempenho acadêmico. A pesquisa foi dividida em duas fases: na primeira buscou-se apresentar uma revisão sistemática para encontrar estudos que abordem o fenômeno do engajamento e seus desdobramentos; na segunda fase aplicou-se técnicas de mineração de dados educacionais (EDM) para extrair e analisar dados comportamentais de seis mil e quinhentos e vinte e sete estudantes ao longo de um curso de graduação. Como resultado da revisão sistemática foi possível obter as respostas das cinco questões de pesquisas nos vinte e seis artigos retornados nos repositórios de busca IEEExplore, Science Direct e Springer. Além disso, os resultados da aplicação da técnica de EDM possibilitaram identificar três perfis diferentes de engajamento, que podem contribuir para a tomada de decisão pedagógica, bem como o desenvolvimento de desenhos metodológicos que diminuam os níveis de evasão em um curso.
Ethosdenken
Authors: Aurenque Diana
Published: April 2022

Dieses Buch beschäftigt sich mit dem viel besprochenen, aber weiterhin unklaren Verhältnis zwischen Heideggers Philosophie und Ethik. Es wird die These vertreten, dass sich Heideggers gesamtes Denken als ein Ethosdenken interpretieren lässt. Dieses darf aber weder als ein ethisches System noch als eine heideggersche Ethiklehre missverstanden werden. Ethos ist nicht moralisch zu verstehen, sondern es meint den Aufenthalt, in dem der Mensch seinem eigenen Wesen und dem Wesen aller Dinge gerecht wird. Heideggers Ethosdenken will dem Menschen keinen Schutz geben, sondern allen Phänomenen in ihrem jeweiligen Sichzeigen und Sichentziehen gerecht werden. Dieses ethische Denken versucht eine Offenheit für das Andere, für das Mögliche und Unbekannte, zu schaffen. Heideggers Ethosdenken liegt unmissverständlich das Ideal des philosophischen Lebens zugrunde. Ob das philosophische Ethos als ein einsames Ethos zu verstehen ist, wird im Buch systematisch geklärt. Zugleich wird Heideggers Ethosdenken im Hinblick auf sein Verständnis des Politischen gedeutet. Das philosophische Wesen des Menschen, das im eigentlichen Ethos erscheint, ist gerade, was Heidegger durch seine entpolitisierte Politik hervorzuheben versucht.
The Place of Elastography for Liver Tumors Assessment
Authors: Ghiuchici Ana-Maria , Dănilă Mirela
Published: April 2022

Elastography is an ultrasound (US) based method widely used in the field of hepatology, particularly for liver stiffness assessment in patients with chronic liver disease. Elastography brings valuable information regarding tissue stiffness and could be considered a virtual biopsy. In the last years, the incidence of focal liver lesions (FLLs) has increased due to frequent detection during a routine abdominal US. The differential diagnosis of FLLs can be challenging, and it is important in terms of treatment options and prognosis. Currently, most FLLs require for diagnosis workup imaging methods with contrast (radiation exposure, potentially nephrotoxic contrast agents) and/or biopsy that are considered invasive procedures and could be contraindicated in particular cases. Avoidance of these invasive methods could be the main reason to perform elastography for FLLs evaluation as they are commonly first detected on US examination. Several studies showed that elastography could bring additional information regarding the stiffness of FLLs in order to predict their nature.
Health Insurance in the United States: Failure of Private and Multi-Payer Financing
Authors: Geyman John
Published: April 2022

Since the 1960s, the United States has subscribed to a business model of health care, largely for-profit with most private insurers on a mission to maximize their own revenues. Most insurers use cost sharing through deductibles and copayments based on the principle that enrollees will overuse health care services unless they have enough “skin in the game.” As health care has been corporatized within a medical-industrial complex, even public insurers such as Medicare and Medicaid have been privatized with the same mission. Employer-sponsored health insurance has been the core of insurance in the U.S. since World War II, but has become unaffordable for employers and employees alike. This article brings historical perspective to how health insurance has been transformed from its not-for-profit origins in the 1930s, how it has become unaffordable in recent decades as it costs more and covers less, and how our multi-payer financing system has failed the public interest. Reform alternatives are discussed, but a system of universal coverage through a public, single-payer national plan is still beyond reach politically.
Commercial-off-the-Shelf (COTS) Games: Exploring the Applications of Games for Instruction and Assessment
Authors: R. Sanchez Diana , Rueda Amanda , Jimeno Jimènez Leila , Norouzi Nargesi Mahsa
Published: April 2022

Despite the growing interest in utilizing commercial off-the-shelf (COTS) games for instructional and assessment purposes there is a lack of research evidence regarding COTS games for these applications. This chapter considers the application of COTS games for instruction and assessment and provides preliminary evidence comparing COTS game scores to traditional multiple-choice assessments. In a series of four studies, we collected data and compared results from the performance in a COTS game to scores on a traditional multiple-choice assessment written for the purposes of each study. Each assessment was written to evaluate the same content presented in the game for each respective study. Three of the four studies demonstrated a significant correlation between the COTS game and the traditional multiple choice assessment scores. The non-significant value in Study 4 was likely due to a small sample size (n < 100). The results of these studies support our hypothesis and demonstrate that COTS games may be a useful educational tool for training or assessment purposes. We recommend that future research focuses on specific applications of COTS games to explore further opportunities for utilizing COTS in education and assessment.
Banking Regulation for ESG Principles and Climate Risk
Authors: Cerrone Rosaria
Published: April 2022

Nowadays banking activity is greatly influenced by environmental and social conditions. For this reason, regulators have been committed to defining Environment, Social, and Governance (ESG) principles. In addition, climate change has shown the relevance of climate risks that have relevant implications in the new risk management process. The 2030 Agenda for Sustainable Development is based on the 17 SDGs that are, in the next future, the main challenge for the worldwide economy as they will be the basis for real sustainable activities. In this context, banks play a very relevant role as they have the power to lead this new challenge and are able to facilitate businesses to run toward a sustainable green economy. For this reason, banks’ activity is now oriented to increase and allocate credit and investment to more sustainable sectors. As climate risk is, at the same time, cause and effect for a socially responsible activity, regulators have been considering the role of banks for the green and ecological transition, which is necessary to face this new risk. The chapter is an overview of rules, regulations, and guidelines for banks referred to ESG principles and their adoption in a global perspective; it also refers to climate risk that, due to its components, may require further capital to preserve banks’ stability.
Pharmacological Treatment of Patent Ductus Arteriosus in Preterm Infants
Authors: Surak Aimann
Published: April 2022

The patent ductus arteriosus contribute to many neonatal morbidities. There are different approaches for treatment including conservative, pharmacological and definitive closure. Most commonly, pharmacological therapy is attempted before consideration of surgical intervention.
BUILDING A TOMOGRAPHIC VELOCITY MODEL FOR SAMOYLOV ISLAND AREA (LENA DELTA) FROM LOCAL SEISMOLOGICAL DATA FOR THE PERIOD OF 2019–2021
Authors: Dergach P. A. , Eponeshnikova L. Y. , Ponasenko S. N. , Kartoziia A. A. , Geissler W. H. , Duchkov A. A. , Shibaev S. V. , Zobnin G. Y.
Published: April 2022

In our paper we present the results of seismotomographic inversion for the local seismological monitoring data obtained in the area of the Samoylov Island (Lena River delta) in 2019–2021. Tomographic velocity model was used for refining hypocenter locations of local earthquakes and for geological interpretation. The results are shown as maps of anomalies of seismic waves and Vp /Vs ratios for the 5 and 10 km depths. The velocity anomalies structure made it possible to interpret low Vp /Vs ratio as rocks related to the Siberian platform, and to compare between the boundary of the low Vp /Vs area and the trace of the known geological fault running along the Olenekskaya Channel.
Evaluating the Efficacy of the National Early Warning Score in Predicting the Mortality of Stroke Patients Admitted to Intensive Care Units
Authors: Mohammadian Erdi Ali , Yousefian Mahzad , Isazadehfar Khatereh , Badamchi Fatemeh
Published: April 2022

Background: National Early Warning Score (NEWS) is a tool used to identify patients at risk. Scores are based on initial clinical observations, including heart rate, respiration rate, systolic blood pressure, oxygen saturation, level of consciousness, body temperature, and oxygen support. To date, few studies have been conducted on NEWS evaluation worldwide, and no study has been conducted in Iran. Objectives: This study aims to evaluate the efficacy of the NEWS in predicting the mortality of stroke patients admitted to intensive care units (ICU). Methods: The present cross-sectional study included 90 patients with a definitive diagnosis of cerebrovascular accident (CVA) based on symptoms and para-clinical evidence. At the beginning of admission to the ICU and up to first 24 hours of admission, all NEWS parameters were measured and evaluated. Results: There was a significant relationship between systolic blood pressure, respiratory support, heart rate, and level of consciousness with patients’ discharge status. Also, there was no significant relationship between age, sex, respiratory rate, SPO2, and fever with discharge status. In addition, there was a significant relationship between clinical risk based on NEWS scoring system and patients’ status. Conclusions: Our results showed a significant relationship between clinical risk based on NEWS scoring and patients’ discharge status so that there was a significant increase in mortality in patients with higher NEWS.
Perception of shop floor employees regarding senior management support in lean projects and its relationship with initiatives success
Authors: Torres Luis F. , Anholon Rosley , Rampasso Izabela Simon , Quelhas Osvaldo L. G. , Leal Filho Walter , Silva Dirceu
Published: April 2022

Purpose – Over the years, the lean production philosophy has shown satisfactory results for companies from different sectors in different countries. Aiming to contribute to the knowledge base on the mentioned philosophy, this study aims to verify the perception of shop floor employees regarding senior management support in lean projects and its relationship with initiatives success.
 
Design/methodology/approach – Through a literature review, 18 aspects of a lean journey were identified and divided into four constructs by a panel of specialists. This information was used to compose a questionnaire, and a survey was conducted with 198 shop floor employees of two auto parts companies. Data analysis was done via Structural Equation Modeling.
 
Findings – As a general result, it was possible to prove that when employees perceive more significant support from senior management in lean projects, the greater is the perception of initiatives success. Therefore, it is interesting that the involvement of senior management occurs at all stages of the project.
 
Originality/value – The results described here have practical implications, especially for managers interested in implementing lean projects; they must be aware of the importance of senior management support for the success of previous projects.
Adoption intention of photovoltaic solar systems
Authors: Filgueira Álvaro José de Araújo , Lima Afonso Carneiro , Castelo José Sarto Freire
Published: April 2022

Purpose – The research objective is to analyze the influence of key factors contributing to consumers’ purchase intention grid-connected photovoltaic systems among residential energy consumers.
Design/methodology/approach – A survey based on Korcaj et al. (2014) was conducted in a major Brazilian city; 209 valid responses were obtained directly. Data was analyzed using structural equation modeling.
Findings – Among significant decision influences are environmental, financial, and autarchy benefits onto perceived global benefit and perceived behavioral control construct onto purchase intention; perceived social benefits, however, were not a relevant influence as opposed to previous studies.
Research limitations/implications - Weakness of the model's reliability leading to the exclusion of the perceived total cost construct, which in turn could reduce sample bias and increase the reliability of the model and regarding clarity regarding the product “solar photovoltaic energy system”, as no text was used; this could have left questions unanswered due to the lack of knowledge of respondents about solar technology.
Practical implications - The high purchasing power and high education level, along with favorable weather and geography, may contribute to promising perspectives for the product. Furthermore, to promote adhesion of the technology in the city there is a need to increase benefits, to reduce perceived technology costs, and to value the importance of solar energy generation among reference groups.
Social implications - The analysis of factors influencing the city’s residents’ intentions of to adopt photovoltaic systems favors further promotion of the technology in the city.
Originality/value - It contributes to the development of consumer behavior studies regarding the adoption intention of ecologically sustainable technologies, i.e., GCPSs, thus, filling a gap in the literature on consumer behavior for this product.
Development and validation of an LC-MS/MS method for determination of 8-iso-prostaglandin f2 Alpha in human saliva
Authors: Tomova Zlatina , Tomov Desislav , Vlahova Angelina , Chaova-Gizdakova Veneta , Yoanidu Lyubka , Svinarov Dobrin
Published: April 2022

Background: Increased formation of reactive oxygen species may be caused by the ion release of the metal alloys used in prosthetic dental restorations due to the corrosion process. As products of lipid peroxidation, isoprostanes can be used as a marker for oxidative stress in the body. There are two significant advantages of using isoprostanes as an oxidative stress marker - presence in all fluids in the body and low reactivity. Saliva provides noninvasive, painless, and cost-effective sample collection and can be used as an alternative testing medium of blood and urine. Methods: This study presents the development and validation of a sample LC-MS/MS method to quantify 8-isoprostaglandin F2-a in human saliva using salt-out assisted liquid-liquid extraction (SALLE). Results: The selected sample preparation procedure optimized chromatographic separation and mass detection provided high recovery and sensitivity of the analysis. The calibration curve was obtained in the predefined range 25-329 ng/L with R2 larger than 0.995. Normalized matrix varied between 89.7 % and 113.5%. The method showed sufficient accuracy and precision - accuracy in the range 89.7 %-113.9 %, and precision between 2.3% and 5.4%. Conclusions: The proposed method is validated according to current EMA/FDA industrial guidance for bioanalysis and offers an appropriate level of sensitivity and sufficient accuracy and precision.
O tinkercad como ferramenta digital potencializadora para aprendizagem sobre as fases do tratamento da água
Authors: Ferreira Naama Pegado , Silva Clécio Danilo Dias da
Published: April 2022

O estudo da água, bem como, a suas fases, ciclo e tratamento é de suma importância para a formação do estudante dentro do ensino de Ciências.  Diante disto, o presente trabalho surgiu da necessidade da montagem de uma maquete, para facilitar a compreensão dos estudantes sobre o tratamento da água e suas fases em uma E.T.A (Estação de Tratamento de Água). Devido ao momento de pandemia vivido, também no Brasil, decorrente do vírus da Covid-19 o projeto foi elaborado e aplicado de forma virtual com estudantes de 03 turmas do 6º ano do ensino fundamental. Neste, a temática sobre a água foi desenvolvida em 6 aulas consecutivas, dentro do componente curricular de Ciências, seguindo as seguintes etapas: i) Discussão da escassez de água no mundo; ii) produção de desenho no formato de uma mão, sobre como economizar água; iii) vídeo para diferenciar a Estação de Tratamento e Água (ETA) e Estação de Tratamento de Esgotos (ETE), iv) orientações para o trabalho individual e uso do Software Tinkercad, v) produção das maquetes virtuais e apresentação dos trabalhos executados. Por meio das atividades realizadas, os estudantes utilizaram pela primeira vez a ferramenta tecnológica Tinkercad, comumente usadas por designs e /ou arquitetos, para representar as fases do tratamento de uma E.T. A. (Estação de Tratamento de Água) e obtiveram resultados muito satisfatórios, facilitando a aprendizagem sobre o tema água no ensino de Ciências.
Gestão Ambiental em espaços educacionais como instrumento para promover a cidadania
Authors: Carvalho Stella Marys Meneses de , Manzini João Victor Mançano Cardoso , Egidio Jonatha Anderson Fraga
Published: April 2022

Gestão Ambiental (GA) são estratégias voltadas para a minimização dos impactos ambientais e a realização de ações que podem colaborar para uma tomada de atitude mais favorável na relação entre a humanidade e o ambiente. Os espaços formais de ensino são espaços onde essas atividades promovidas pelas GA podem ser colocadas em prática, visto que as instituições de ensino tem como missão o desenvolvimento da cidadania dos estudantes presentes. Assim, o objetivo deste trabalho foi identificar como a atuação de projetos de GA colaboram com os processos de ensino e aprendizagem dentro de espaços educacionais de maneira que possam promover o desenvolvimento da cidadania dos envolvidos. Através de algumas análises bibliográficas foi possível identificar que a GA possui significativa influência na formação de cidadania das pessoas envolvidas em seus projetos. As instituições de ensino são espaços onde esses projetos podem ser aplicados por meio da Educação Ambiental. Percebe-se também que há muito trabalho pela frente quando falamos de GA, mas que cada ação em favor dessa gestão é importante para que possamos alcançar a promoção de uma vida com mais qualidade e de forma sustentável para a sociedade
Temporalising the house: exploring alternative perspectives on time and the archaeological record within Danish settlement archaeology
Authors: Beck Anna Severine
Published: April 2022

This article calls for a renewed debate on the role played by time and temporality within Danish settlement archaeology. Recent theoretical debate has challenged the conventional way of thinking about time in archaeology by drawing attention to the multitemporal character of the archaeological record. In the article, the temporalisation of the archaeological record of the house is discussed based on a critical review of the archaeological process. The analysis shows how basic excavation and archiving practices favours a temporalisation of the house based on the chronological date and, at best, downplays other temporalities. The inherent temporalities of the archaeological record of the house, particularly the posthole, are discussed, and it is argued that the posthole should both be perceived as an object and a process in order to create space for alternative temporalities. Instead of seeing stratigraphy as a property of the posthole, the postholeshould be seen as an assemblage made up of the events and materials that created the stratigraphy, a process which is directly related to the life history of the house. It is argued that amultitemporal perspective is a prerequisite for new and fruitful ways to understand the house as an archaeological and cultural phenomenon.
Positive Law of Environment and John Ruggie Principles: Between Legal Texts and Norms
Authors: Joesoef I E
Published: April 2022

The aim of this research is to examine the application of the Guiding Principles for Business and Human Rights, that is Protection, Respect and Recovery in the implementation of the Law on Environmental Protection and Management (Environment Law). In 2015 the government issued the Presidential Regulation Number 75 of 2015 regarding to the National Action Plan for Human Rights 2015-2019 (NAP Human Rights). In 2020 the government is simplifying laws and regulations with the new concept of legal drafting that is the Omnibus Law of which government stated the law of which be familiar as Job Creation Law. One of the simplified clusters is the Environment Law. The findings show that many amended legal norms in the Environment Law are inconsistent with and even contradictory to the NAP Human Rights. Research is carried out normatively by paying attention to legal issues in social media as legal material, as well as reviewing scientific literature related to the topic of issues, laws and regulations, and court decisions. The conclusion from the research is that the Guiding Principles of United Nations for Business and Human Rights bind Judges in enforcing the Environment Law even though these principles are still at the level of the National Action Plan and have not yet entered into the level of legislation.
B. Tishchenko's Music for S. Shuster's Documentaries (on the issue of the radical renewal of Russian Symphonism in the 1960s)
Authors: Serov Iurii Eduardovich
Published: April 2022

The subject of the study is the symphonic work of the outstanding Russian composer of the second half of the twentieth century Boris Ivanovich Tishchenko (1939-2010). The article discusses his music for the documentary films directed by S. Shuster "Suzdal" (1964), "Palekh" (1965) and "Northern Studies" (1968). The author of the work dwells in detail on such aspects of the topic as Tishchenko's innovative role in the renewal of Russian symphonism in the second half of the last century, reformatting the very foundations of compositional thinking, enriching the sound palette with the help of modern musical avant-garde. Special attention is paid to the issue of B. Tishchenko's inheritance of the great Russian symphonic tradition. В  The main conclusion of the article is the idea that B. Tishchenko's music for documentaries of the 1960s accumulated the freshest ideas of the period of renewal in Russian art. A special contribution of the author to the study of the topic is a detailed study of three little-known scores of the composer in the context of an intensive search for "new music". The novelty of the research lies in the fact that the author examines the composer's compositions through the prism of stylistic and linguistic innovations of the 1960s, proves the close connection of Tishchenko's symphonism with his time, with the contradictory cultural and social processes that befell the generation of composers of the "sixties".
Comparative Analysis of Critical Headway Estimation at Urban Single-Lane Roundabouts
Authors: RADOVIĆ Dunja , MOHAN Mithun , BOGDANOVIĆ Vuk
Published: April 2022

According to models commonly used in practice, the capacity of roundabouts largely depends on the value of critical headway. The value of critical headway depends on the characteristics of vehicles, driving conditions, and geometric characteristics of intersections, but also on driver behaviour. Driver behaviour is the result of many factors that depend on the influence of the local environment, driver habits, mentality, etc. Accordingly, to calculate the capacity of roundabouts within the op-erational and planning analyses of roundabouts more accurately, it is necessary to use data that correspond to local conditions. In this paper, the critical headway was estimated at five urban single-lane roundabouts using five methods: Harders’, Logit, Raff’s, Wu’s, and the max-imum likelihood method. In order to determine which of the stated methods provides the most realistic estimate of critical headway, a comparison of field capacity values with theoretical capacity values was performed. Based on the comparative analysis performed in MATLAB, as well as the calculation of percentage prediction error, it was found that the Harders' method provides the most accurate estimate of critical headway at observed round-abouts in two cities in Bosnia and Herzegovina. Due to the similarity in the design of roundabouts and driver be-haviour, the results obtained in this paper can be applied in the surrounding countries, i.e., Southeast Europe
Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry
Authors: Wei Tiantian , Wang Jue , Liang Ruqi , Chen Wendong , Chen Yilan , Ma Mingzhe , He An , Du Yifei , Zhou Wenjing , Zhang Zhiying , Zeng Xin , Wang Chu , Lu Jin , Guo Xing , Chen Xiao-Wei , Wang Youjun , Tian Ruijun , Xiao Junyu , Lei Xiaoguang
Published: April 2022

The dual-specificity tyrosine phosphorylation-regulated kinase DYRK2 has emerged as a critical regulator of cellular processes. We took a chemical biology approach to gain further insights into its function. We developed C17, a potent small-molecule DYRK2 inhibitor, through multiple rounds of structure-based optimization guided by several co-crystallized structures. C17 displayed an effect on DYRK2 at a single-digit nanomolar IC50 and showed outstanding selectivity for the human kinome containing 467 other human kinases. Using C17 as a chemical probe, we further performed quantitative phosphoproteomic assays and identified several novel DYRK2 targets, including eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) and stromal interaction molecule 1 (STIM1). DYRK2 phosphorylated 4E-BP1 at multiple sites, and the combined treatment of C17 with AKT and MEK inhibitors showed synergistic 4E-BP1 phosphorylation suppression. The phosphorylation of STIM1 by DYRK2 substantially increased the interaction of STIM1 with the ORAI1 channel, and C17 impeded the store-operated calcium entry process. These studies collectively further expand our understanding of DYRK2 and provide a valuable tool to pinpoint its biological function.
Morphological, functional, and phylogenetic aspects of the head capsule of the cockroachErgaula capucina(Insecta/Blattodea)
Authors: Wipfler Benjamin , Triesch Felix , Evangelista Dominic , Weihmann Tom
Published: April 2022

Background

Cockroaches are usually typical omnivorous detritivores and their cephalic morphology is considered to be ancestral in various aspects. Thus, several studies addressed the morphology and function of the blattodean head, and the cockroach usually serves as a model for standard mouthparts in text books. However, so far only two of the three major lineages of Blattodea have been studied and no detailed information for the head of any Corydioidea was available. The present study closes this gap by providing a detailed morphological description of the head ofErgaula capucina, studying some important functional parameters of the mandible and discussing it in a phylogenetic framework.

Methods

The cephalic morphology ofErgaulastudied in detail using a broad set of different techniques including digital microscopy, µ-computed tomography, and 3-dimensional reconstructions. Concerning the functional morphology of the mandible, we compared the volume and effective cross sections of the eight compartments of the primary mandibular adductor muscle forErgaula,Blattella germanica, andSalganea rossiand measured the mechanical advantage,i.e., the force transmission ratio for all teeth of the mandible ofErgaula.

Results

The head capsule ofErgaulais characterized by a strong sexual dimorphism and typical orthopteran mouthparts. It resembles the head capsule of other roaches in several respects and confirms oesotendons, the reduction of the mesal occelus, and bipartite M. verticopharyngealis and M. hypopharyngosalivaris as blattodean apomorphies. But it also shows some unique adaptations. It is the first described cockroach that lacks the dorsal tentorial arms which has various consequences for the cephalic musculature. On the maxillary lacinia,Ergaulais the first described blattodean to show strong and blunt setae instead of a lacinula, which might be homologues to the dentisetae of dragonflies and mayflies. Like other corydiid roaches that inhabit xeric areas,Ergaulahas an atmospheric water-vapor absorption mechanism that includes a gland and a ductus on the epipharnyx and bladders on the hypopharynx. The mandibular adductor is in cockroaches asymmetric, a pattern not found in termites, mantids, or other closely related insects.
Phosphorus flow analysis of different crops in Dongying District, Shandong Province, China, 1995–2016
Authors: He Huan , Zhang Lvqing , Zang Hongwei , Sun Mingxing , Lv Cheng , Li Shuangshuang , Bai Liyong , Han Wenyuan , Dai Jiulan
Published: April 2022

Investigating the phosphorus (P) sources, pathways, and final sinks are important to reduce P pollution and improve P management. In this study, substance flow analysis (SFA) was performed for P flow analysis from 1995 to 2016 in different crops of Dongying District, a core region of the alluvial delta at the estuary of the Yellow River. The results showed that P input steadily increased from 1.48 × 104 t in 1995 to 2.16 × 104 t in 2007, and then decreased from 1.90 × 104 t in 2010 to 1.78 × 104 t in 2016. Chemical fertilizers made the highest contribution to P input. The cotton with the highest P load was on the top of P load risk ranks. More importantly, this study applied the Partial Least Squares Path Modeling (PLS-PM) model for P flow analysis and established the numerical relationship between the variables (including fertilizers, straws return-to-field, harvested grains, discarded straw, and P erosion and runoff), P use efficiency (PUE) and P load. The analysis revealed that fertilizer and crop production are the key factors affecting the PUE. Therefore, optimizing the use of P-fertilizer whilst maintaining yields can be an effective strategy to improve the local region PUE.
Comunicação Não-violenta: assertividade no discurso e sua importância nas organizações
Authors: Ramos Gonçalves Nathália , Daiane da Rocha Viviane , Do Carmo Ferreira Lima Maria
Published: April 2022

Este estudo apresenta a Comunicação Não-violenta e a assertividade como ferramentas para melhorar os processos de comunicação e garantir um ambiente de trabalho saudável. O principal objetivo foi avaliar se as falhas na comunicação prejudicam, emocionalmente, os profissionais e se o uso de uma abordagem mais amigável pode reduzir as situações de violência verbal vivenciadas dentro das empresas; bem como determinar se existe essa preocupação, por parte das empresas, em incentivar a CNV e assertividade para melhorar os processos comunicacionais. Foi utilizado o método quantitativo para coletar informações e opiniões sobre a frequência dessa problemática no meio corporativo, sobre a iniciativa das organizações em incentivar o desenvolvimento dessas habilidades e verificar a familiaridade dos respondentes com a CNV. Os resultados obtidos permitiram comprovar que a maioria dos afetados pela violência verbal é o público feminino e mesmo enfrentando esse problema um alto percentual de entrevistados se sentem satisfeitos com a comunicação de suas empresas e consideram-se inseridos num ambiente salutar. Conclui-se que o reconhecimento do método da CNV pode impactar significativamente no convívio social, consequentemente na redução do número de violência e conflitos, uma vez que haja uma iniciativa por parte das pessoas da utilização desse método.
Studies on Pest Complex of Broad Leaf Mustard, Brassica juncea var. rugosa Roxb. Tsen and Lee in the Valley of Manipur
Authors: Rajeshwari Dosa , Mamocha Singh K.
Published: April 2022

A experiment was conducted at Entomological Research Farm, Department of Entomology, College of Agriculture, Central Agricultural University, Imphal. Total eleven insect pest species were found to infest the crop viz. Large cabbage white butterfly, Pieris brassicae; Asian cabbage  white butterfly, Pieris canidia; mustard aphid, Lipaphis erysymi and striped flea beetle, Phyllotreta striolata were observed frequently while, Cabbage aphid, Brevicoryne brassicae; green peach aphid, Myzus persicae; crucifer flea beetle, Phyllotreta cruciferae; mustard sawfly, Athalia lugens proxima; cabbage semilooper, Trichoplusia ni; fungus beetle, Monolepta signata and tobacco grasshopper, Atractomorpha crenulata were observed rarely.
Impact of Fertilization of Sulphur and Iron on Yield Attributes and Economics of Greengram (Vigna radiata L.)
Authors: Suman Sudhanshu , Singh Rajesh , Singh Ekta , Dwivedi Kalyani
Published: April 2022

At Crop Research Farm, Department of Agronomy, SHUATS, Prayagraj, UP (India), a field experimentation was undertaken in zaid 2021. The experimental plot's soil texture was sandy loam. At the same time pH, low organic carbon, available N, available P and available K were (7.4), (0.32%), (188.3 kg/ha), (34.5 kg/ha) and (87.5 kg/ha) respectively. The experiment was set up in a Randomized Block Design (RBD) with 12 treatments and three replica. The results showed that treatment 5 with application of 20kg/ha Sulphur as Gypsum + 20kg/ha Sulphur as Single Super Phosphate + 25kg/ha FeSO4 as basal dose application was recorded maximum no. of pods per plant (36.07), no. of seeds per pod (12.07), test weight (37.03 g), seed yield (1421.00 kg/ha), stover yield (3306.00 kg/ha), harvest index (30.06%), gross return (1,31,196.00 INR/ha), net return (87,806.00 INR/ha) and benefit cost ratio (2.02) as compared to other treatments.