bluuebunny/crossref_metadata_2025 huggingface dataset:
Adenosine monophosphate-activated protein kinase activator inhibits activation of fibroblast-like synoviocytes but promotes hyaluronan and proteoglycan link protein 1 secretion
Authors: Chen Yong , Fujuan Qiu , Beijia Yu , Fangfang Zuo , Yanan Bi , Ensheng Chen , Xiaofeng Zhao , Yi Yuan , Yanyan Cao , Zhu Shaoyu , Yanan Xuan , Yanjuan Chen , Yongpu Liu , Kaiqin Li , Nandakumar Kutty Selva , Changhong Xiao
Published: February 2020

Objectives: To determine whether any correlation exists between disease activity and AMPK levels in rheumatoid arthritis (RA) patients and investigate the effects of AMPK activator treatment on RA fibroblast-like synoviocytes (RA-FLS).Methods: Serum AMPK-α1, p-AMPK-α1, TNF-α and IL-17 levels between osteoarthritis (OA) and RA patients having different disease activities were compared by ELISA. Differentially expressed genes (DEGs) between RA and OA synovium from NCBI GEO Profiles (accession numbers: GSE1202112, GSE55235, GSE5545713) were identified and the genes intersecting in all the three datasets were selected for enrichment analysis. Immunohistochemical staining was done with synovium obtained from OA and RA patients for p-AMPK-α1. AMPK gene expression in synovium was semi-quantified by RT-qPCR. RNA sequencing of FLS was performed and DEGs were selected for KEGG enrichment analysis. AMPK activator, metformin, treated RA-FLS were tested for proliferation and migration by MTT and scratch test, respectively. Expression of IL-6, AMPK-α1, PKA-α, RAPTOR, mTOR, HAPLN1, RUNX1 and RUNX2 genes were determined by qPCR. Phosphorylated AMPK-α1 and HAPLN1 levels were determined by an automated electrophoresis-western blot analysis method.Results: In RA sera, a positive correlation between p-AMPK-α1 levels and DAS28 (r = 0.270, 95%CI: 0.142-0.492, p < 0.0001) as well as CRP levels (r = 0.259, 95%CI: 0.009-0.478, p < 0.05) was found. Similarly, a positive correlation was observed between AMPK-α1 and TNF-α levels (r = 0.460, 95% CI: 0.241-0.640, p = 0.0002). DEGs between OA and RA synovium from NCBI GEO profiles and our RNA sequencing data suggested activation of metabolic pathways specific to RA-FLS. AMPK-α1 was highly expressed in the synovium of RA but not OA patients. Metformin at higher concentrations inhibited RA-FLS proliferation in a dose dependant manner, however, at lower concentrations it has an opposite effect. On the other hand, AMPK inhibitor, dorsmophin, promoted the proliferation of RA-FLS significantly. Interestingly, both metformin and dorsmophin substantially inhibited the migration of RA-FLS. In FLS, relative expression level of IL-6 mRNA was significantly decreased after metformin treatment, while the expression of AMPK-α1, PKA-α and HAPLN1 genes were significantly increased. Western blot analysis confirmed increased expression of p-AMPK-α1 and HAPLN1 genes in the metformin treated FLS.Conclusions: Inflammatory stress in RA synovium leads to an increase in AMPK levels, possibly as a protective mechanism. AMPK activator but not metformin per se could be a potential therapeutic for RA by promoting HAPLN1 secretion to protect the joints.
Relative anomalies in (2+1)D symmetry enriched topological states
Authors: Barkeshli Maissam , Cheng Meng
Published: February 2020

Certain patterns of symmetry fractionalization in topologically
ordered phases of matter are anomalous, in the sense that they can only
occur at the surface of a higher dimensional symmetry-protected
topological (SPT) state. An important question is to determine how to
compute this anomaly, which means determining which SPT hosts a given
symmetry-enriched topological order at its surface. While special cases
are known, a general method to compute the anomaly has so far been
lacking. In this paper we propose a general method to compute relative
anomalies between different symmetry fractionalization classes of a
given (2+1)D topological order. This method applies to all types of
symmetry actions, including anyon-permuting symmetries and general
space-time reflection symmetries. We demonstrate compatibility of the
relative anomaly formula with previous results for diagnosing anomalies
for \mathbb{Z}_2^{T}ℤ2T
space-time reflection symmetry (e.g. where time-reversal squares to the
identity) and mixed anomalies for U(1) \times \mathbb{Z}_2^{T}U(1)×ℤ2T
and U(1) \rtimes \mathbb{Z}_2^{T}U(1)⋊ℤ2T
symmetries. We also study a number of additional examples, including
cases where space-time reflection symmetries are intertwined in
non-trivial ways with unitary symmetries, such as
\mathbb{Z}_4^{T}ℤ4T
and mixed anomalies for \mathbb{Z}_2 \times \mathbb{Z}_2^{T}ℤ2×ℤ2T
symmetry, and unitary \mathbb{Z}_2 \times \mathbb{Z}_2ℤ2×ℤ2
symmetry with non-trivial anyon permutations.
A Review on the Recent Flavoring Herbal Medicines of Today
Authors: Pal Rashmi S. , Pal Yogendra , Saraswat Nikita , Wal Pranay
Published: February 2020

Background:

Herbs are the most trending taste enhancers, carrying multiple benefits. Sprinkling them in minute amounts in pasta, salads, sautéed vegetables, curries, fried rice or adding them in dips and sauces can lead to enhanced flavours. The fresh and dried versions serve the same purpose, especially when the fresh ones are not available.

Objective:

The objective of this article is to explore and review trending flavouring herbs of the present era with reference to the knowledge available from previous texts.

Materials and Methods:

A literature review has been performed on various herbs such as dill, cilantro, parsley, chives, mint, oregano, etc, which can be used as healthy and taste enhancing sprinklers and garnishers for foods.

Results:

There are various herbs present in nature in many forms and patterns, some provide anti-inflammatory benefits, are anti-microbial and most of them are digestive in nature.

Conclusion:

These herbs are very rich in phytoconstituents, having multiple properties like anti-oxidant and carminative effects. They are superior as compared to artificial additives as well.
Microwave-accelerated Carbon-carbon and Carbon-heteroatom Bond Formation via Multi-component Reactions: A Brief Overview
Authors: Kamanna Kantharaju , Khatavi Santosh Y.
Published: February 2020

Multi-Component Reactions (MCRs) have emerged as an excellent tool in organic chemistry
for the synthesis of various bioactive molecules. Among these, one-pot MCRs are included, in
which organic reactants react with domino in a single-step process. This has become an alternative
platform for the organic chemists, because of their simple operation, less purification methods, no side
product and faster reaction time. One of the important applications of the MCRs can be drawn in carbon-
carbon (C-C) and carbon-heteroatom (C-X; X = N, O, S) bond formation, which is extensively
used by the organic chemists to generate bioactive or useful material synthesis. Some of the key carbon-
carbon bond forming reactions are Grignard, Wittig, Enolate alkylation, Aldol, Claisen condensation,
Michael and more organic reactions. Alternatively, carbon-heteroatoms containing C-N, C-O,
and C-S bond are also found more important and present in various heterocyclic compounds, which
are of biological, pharmaceutical, and material interest. Thus, there is a clear scope for the discovery
and development of cleaner reaction, faster reaction rate, atom economy and efficient one-pot synthesis
for sustainable production of diverse and structurally complex organic molecules. Reactions that
required hours to run completely in a conventional method can now be carried out within minutes.
Thus, the application of microwave (MW) radiation in organic synthesis has become more promising
considerable amount in resource-friendly and eco-friendly processes. The technique of microwaveassisted
organic synthesis (MAOS) has successfully been employed in various material syntheses,
such as transition metal-catalyzed cross-coupling, dipolar cycloaddition reaction, biomolecule synthesis,
polymer formation, and the nanoparticle synthesis. The application of the microwave-technique in
carbon-carbon and carbon-heteroatom bond formations via MCRs with major reported literature examples
are discussed in this review.
Phytochemical Composition, Pharmacological Properties, and Therapeutic Applications of Celastrus paniculatus
Authors: Kandikattu Hemanth Kumar , Amruta Narayanappa , Khanum Farhath , Narayana V.V.P.C. , Srinivasulu Doddaga
Published: February 2020

Humans experience different kinds of stress as a part of the day to day activity.
The manifestation of stress will aggravate based on the physical conditions of individuals
and due to their socio-economic situation of living. Herbal extracts have long been used in
the traditional systems of medicine for the treatment of various ailments because of their potent
antioxidant activity and lesser or no side-effects. Recently, there is a surge of interest
toward the search of natural substances with diverse pharmacological activities, that can
scavenge free radicals and protect cells from oxidative damage and apoptosis because of the
adverse effects associated with the use of conventional medicines. Celastrus paniculatus is
an endangered medicinal plant used for years in the traditional Ayurvedic system of medicine.
The review presents the diverse chemical constituents of C. paniculatus and their
pharmacological actions such as neuroprotective, memory-enhancing, anti-depressant, anxiolytic,
anti-aging, hypolipidemic, anticancerous, analgesic, anti-inflammatory, antioxidant,
anti-apoptotic, gastroprotective, anti-ulcerative properties at the cellular and molecular level
based on the pre-clinical and clinical reports available. In the present review, we gathered the
information from sources, such as Google Scholar, Science direct, PUBMED, and reviewed
with a special focus on the mode of action of C. paniculatus at molecular biology from the
data on animal and preclinical experiments to cure various ailments. These diverse medicinal
values of C. paniculatus demonstrate its value as traditional medicine as a cure for multiple
maladies.
The Supremacy of Synergism: A Comparison of Anticancer Activity of Rhizome Extract of Bistorta Amplexicaulis and Gallic Acid in Cancer Cell Lines and Primary Cells
Authors: Batool Salma , Asad M. Javaid , Arshad Muhammad , Saleem Rahman Shah Zaib , Ahmad Muhammad Sheeraz
Published: February 2020

Background:

Bistorta amplexicaulis is a seasonal herb with several folkloric uses. The plant
extract has been shown to possess various activities including antioxidant, anticancer, anti-bacterial,
anti-fungal, cardio-protective, and anti-atherosclerosis activities.

Objective:

The aim of the study was to quantify the activity of the plant extract and relate it to the
activity of the isolated compound, gallic acid.

Methods:

Initially, the plant was extracted, then, the activity of the extract was compared with its
constituent, gallic acid. After this, the cytotoxic potential of the two against human liver cancer cell
line (HepG2), breast cancer cell line (MCF-7) and human umbilical vein endothelial cells (HUVEC)
was evaluated through MTS assay.

Results:

The extract had better activity against HepG2 as compared to gallic acid (IC50 29μg/mL vs
37μg/mL). It also provided a better therapeutic window by having lower toxicity for HUVEC cells
than gallic acid (IC50 63μg/mL vs 47μg/mL), suggesting the use of the extract over the purified gallic
acid for these cells. We also performed the fluorescence study of the rhizome extract in ethanol (REE),
methanol (REM), 80% ethanol (80RE), 80% methanol, (80RM) and acetone (RAC). The highest
intensity of fluorescence was found in REE with excitation at 394 nm and emission at 421nm.

Conclusion:

The comparison of gallic acid with ethanolic rhizome extract of B. amplexicaulis reveals
important insights about utilizing the plant extract over purified gallic acid. The ethanolic extract also has
the potential to be used as an autofluorescent drug during in vitro and in vivo studies.
UNDERSTANDING THE CONCEPT AND MISCONCEPTION OF STUDENT TEACHER IN KEPLER'S LAWS
Authors: Syuhendri Syuhendri , Andriani Nely , Saparini Saparini
Published: February 2020

PEMAHAMAN KONSEP DAN MISKONSEPSI MAHASISWA CALON GURU PADA HUKUM KEPLERAbstrakPenelitian ini bertujuan untuk menginvestigasi tingkat pemahaman konsep dan miskonsepsi mahasiswa calon guru pada hukum Kepler. Subjek penelitian adalah 68 mahasiswa peserta mata kuliah Ilmu Pengetahuan Bumi dan Antariksa (IPBA). Sampel dipilih berdasarkan teknik persampelan purposif. Pengumpulan dan analisis data menggunakan mix method, gabungan penelitian kuantitatif dan kualitatif. Instrumen yang digunakan adalah two-tear test berupa penyusunan peringkat dan pemberian alasan. Analisis dilakukan terhadap dua lapis data yang dianalisis secara bersamaan berdasarkan tingkat pemahaman konseptual. Hasil penelitian menunjukkan tingkat pemahaman konsep bervariasi dengan dominasi Paham Sebagian dan Miskonsepsi (33,82%) untuk Hukum II Kepler dan Paham Sebagian (42,65%) untuk Hukum III Kepler. Penelitian mendapatkan 14 bentuk miskonsepsi berkaitan dengan kecepatan, perioda, dan jarak orbit benda langit mengitari bintangnya dan pengaruh massa serta bentuk orbit ter-hadap variabel kecepatan, perioda, dan jarak orbit. Sebelas miskonsepsi belum dilaporkan pada penelitian sebelumnya. Pembelajaran tradisional tidak berhasil dalam meningkatkan pemahaman konsep karena berorientasi pada penguasaan rumus dan penghafalan fakta. Perlu inovasi pembelajaran untuk meningkatkan penguasaan konsep.Kata kunci: pemahaman konsep, miskonsepsi, hukum Kepler, IPBAAbstractThis study was aimed at investigating the level of understanding of the concepts and misconceptions of teacher students in Kepler's law. The research subjects were 68 students participating in the Earth and Space Sciences (ESS) course. The sample was chosen based on the purposive sampling technique. The collection and analysis of the data used a mixed-method, a combination of quantitative and qualitative research. The instrument used was a two-tear test in the form of ranking and explanation. The analysis was carried out on two layers of data which were then analyzed simultaneously based on an analysis of the level of conceptual understanding. The results show that the level of concept understanding varied with the dominance of Partial Understanding and Misconception (33.82%) for Kepler's Law II and Partial Understanding (42.65%) for Kepler's Law III. The study found 14 forms of misconception related to the velocity, period, and orbital distance of celestial bodies around the star and the effect of mass and orbital shape on variable velocity, period, and orbital distance. Eleven misconceptions have not been reported in previous studies. The failure of conventional learning in improving understanding of concepts is due to the application of traditional approaches that are oriented towards mastering formulas and memorizing facts. Learning innovation is needed to improve the mastery of concepts.
ANALYZING FACTORS INFLUENCING THE TEACHER CAREER PROMOTION
Authors: Saputra Danang Harya
Published: February 2020

ANALISIS FAKTOR YANG MEMPENGARUHI KECEPATAN KENAIKAN KARIR GURU SEKOLAH DASARAbstrakPenelitian ini bertujuan untuk memetakan kemampuan guru dalam menulis karya ilmiah, motivasi berprestasi, disiplin kerja, dan pengaruhnya pada kenaikan pangkat guru; hubungan antara kemampuan menulis karya ilmiah, motivasi berprestasi, disiplin kerja terhadap kecepatan kenaikan pangkat. Penelitian ini merupakan jenis penelitian survei. Subyek penelitian ini adalah guru PNS sekolah dasar negeri di Sleman yang berjumlah 172 orang. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah angket (kuesioner) dan tes. Instrumen yang digunakan telah melalui uji validitas dan reliabilitas dengan metode internal consistency. Data yang terkumpul kemudian dianalisis menggunakan statistika inferensial dengan cara menganalisis korelasi dan analisis regresi sederhana/berganda. Berdasarkan hasil analisis dapat disimpulkan kemampuan guru sekolah dasar negeri dalam menulis karya ilmiah, motivasi berprestasi guru, dan disiplin kerja mayoritas masuk termasuk dalam kategori sedang. Kemampuan guru sekolah dasar negeri dalam menulis karya ilmiah, motivasi berprestasi guru, dan disiplin kerja berpengaruh pada kecepatan kenaikan pangkat guru sekolah dasar negeri.AbstractThis study was aimed at determining teachers' scientific paper writing ability, achievement motivation, work discipline, and the impact on teacher promotion; and the relationship between the ability to write scientific papers, achievement motivation, work discipline to the speed of the promotion. This study was categorized as survey research. The subjects of this study were 172 elementary school teachers (state civil apparatus) in Sleman. The data collection techniques used in this study were questionnaires and tests. The instrument used has been tested for validity and reliability using the internal consistency method. The collected data were then analyzed using inferential statistics by analyzing correlations and simple/multiple regression.The results show that the majority of scientific paper writing ability, achievement motivation, and work disciplines of the teacher are as a medium category. It is also can be found that the writing scientific paper ability, achievement motivation, and work discipline has an effect on their career promotion.
DEVELOPING GUIDED DISCOVERY-BASED MODULE ON THE GENERATING FUNCTION LEARNING MATERIAL
Authors: Iltavia Iltavia
Published: February 2020

PENGEMBANGAN MODUL BERBASIS PENEMUAN TERBIMBING PADA MATERI FUNGSI PEMBANGKITAbstrakPenelitian ini bertujuan untuk mengembangkan modul berbasis penemuan terbimbing pada materi fungsi pembangkit yang akan digunakan selama perkuliahan mata kuliah matematika diskrit. Sampel penelitian sebanyak 15 mahasiswa pendidikan matematika FKIP UMSB. Penelitian pengembangan ini menggunakan model McKenny yang terdiri atas tiga tahap yaitu preliminary, prototyping, dan assessment. Kegiatan analisis kebutuhan dimulai dengan analisis kurikulum, analisis konsep, dan analisis kebutuhan mahasiswa. Validasi modul dilakukan oleh pakar pendidikan matematika, teknologi pendidikan, dan bahasa. Kepraktisan modul dilihat melalui pengamatan pelaksanaan pembelajaran, pengisian angket prediksi menurut para ahli, pengisian angket menurut mahasiswa, dan melakukan wawancara dengan mahasiswa. Keefektifan modul dilihat dari hasil observasi aktivitas dan hasil belajar mahasiswa. Data dianalisis secara deskriptif. Berdasarkan analisis kebutuhan mahasiswa, modul dibutuhkan untuk menemukan konsep materi secara mandiri. Hasil penelitianmenunjukkan bahwa modul berbasis penemuan terbimbing untuk materi fungsi pembangkit pada matakuliah matematika diskrit sudah memenuhi kriteria valid baik dari segi isi maupun konstruk, praktis dari segi keterlaksanaan, kemudahan, dan waktu yang diperlukan, serta efektivitasnya.Kata kunci: modul, fungsi pembangkit, penemuan terbimbingAbstractThis study was aimed at developing a guided discovery-based module on the generating function learning material used during lectures on discrete mathematics courses. The research sample was 15 students of Mathematics Education, Faculty of Education, West Sumatra Muhammadiyah University. This study used McKenny's model which consists of three stages, namely preliminary, prototyping, and assessment. The needs analysis activity started with curriculum analysis, concept analysis, and need analysis. Module validation was carried out by mathematics, education technology, and language education experts. The practicality of the module was seen through observing the implementation of learning, filling in the prediction questionnaire according to experts, filling out the questionnaire according to students, and conducting interviews with the students. The effectiveness of the module was seen from the results of the observation of the student activities and learning outcomes. The data obtained were analyzed descriptively. Based on an analysis of student needs, a module is needed during the lecture process that requires students to discover material concepts independently. The results show that Guided discovery-based modules for generating function in discrete mathematics courses have met valid criteria both in terms of content and construct, practical in terms of feasibility, ease and time required, and the effectiveness.
IMPORTANCE PERFORMANCE ANALYSIS KUALITAS PELAYANAN BADAN PENGELOLAAN PENDAPATAN DAERAH KOTA BANDUNG
Authors: Miftah Ahmad Zaini , Sugandi Yogi Suprayogi , Sukarno Dedi
Published: February 2020

Delivering public service is an important matter where the performance of government institution is equally related to the public satisfactions. This study conducted from nine types of taxes in Bandung Municipal City. Survey has been held to assess the public satisfactions of the tax service performance in Bandung Municipal City for future tax service improvement and innovation to society. Importance-Performance Analysis is being used to measure the service attributes that provided by the authorized government institutions alongside SERVQUAL model from Parasuraman et al. (1985). The results indicate that there is no further handling from the submitted complaint by taxpayers, the limited infrastructure to pay the tax and also the media to convey their dissatisfaction toward current service. Hence, the tax payment system integration is needed which providing tax information base and require procedure to educate the taxpayer and improve accountability of authorized the local government institution.
KAPASITAS SUMBER DAYA MANUSIA SEKSI PENDIDIKAN MADRASAH KANTOR KEMENTERIAN AGAMA KABUPATEN BANDUNG
Authors: Yusuf Ningrum Fauziah , Sintaningrum Sintaningrum , Utami Sawitri Budi
Published: February 2020

This study aims to look at the human resource capacity of the Ministry of Religion especially in  madrasah education. This study wants to explain how the Ministry of Religion in carrying out its duties and responsibilities in the field of madrasah education includes service, guidance, guidance, management of information systems. This study uses a quantitative approach which is analyzed using analysis (Structural Equation Modeling, SEM). Data was collected by informant interviews and questionnaires. As a result, this study shows that currently the human resource capacity of the Ministry of Religion e in the madrasah education section is quite good. This can be seen from the six indicators that researchers use based on the theory of Hall, et al. (2003), which consists of quantity of employees, employee competency standards, employee motivation, reward and punnishment, skill development, and compensation. The results of the study show that in human resource capacity is strongly influenced by the dimensions of employee competency standards and compensation.
RESPONSE OF TURMERIC EXPLANT ON CYTOKININ AND AUXIN IN MURASHIGE AND SKOOG
Authors: Indriani Mita , Suminar Erni , Wicaksana Noladhi , Sobardini Denny , Sulistyaningsih Sulistyaningsih , Nuraini Anne , Nursuhud Nursuhud , Mubarok Syariful
Published: February 2020

This study was aimed at determining the concentration of several types of cytokinins and auxin for the induction of turmeric shoots in vitro. The research was conducted at the Tissue Culture Seed Technology Laboratory, Faculty of Agriculture, Padjadjaran University, Jatinangor. The study was conducted from October 2017 to February 2018. The source of planting material is in the form of shoots from the turmeric rhizome. The source of explants or planting material came from the field collected at the Tissue Culture Seed Technology Laboratory, Faculty of Agriculture, Padjadjaran University. Explants were taken from rhizome buds with a size of 0.6-2.0 cm. The experiment used a Completely Randomized Design which was analyzed using the Student’s T-test method. The number of experimental and control groups in this study were seven groups. Variation in treatment with different BAP, thidiazuron, zeatin, and NAA concentrations in each group. The results show that Thidiazuron 1 mgL-1 + NAA 1 mgL-1 gives better results on the percentage of live explants and number of shoots on turmeric plants (Curcuma domestica Val.) Clones 41 at the age of 14 weeks after planting.RESPONS EKSPLAN KUNYIT PADA SITOKININ DAN AUKSIN DALAM MEDIA MURASHIGE DAN SKOOGPenelitian ini bertujuan untuk mendapatkan salah satu konsentrasi dari beberapa jenis sitokinin dan auksin untuk induksi tunas kunyit secara in vitro. Penelitian dilakukan di Laboratorium Kultur Jaringan Teknologi Benih, Fakultas Pertanian, Universitas Padjadjaran, Jatinangor. Waktu pelaksanaan penelitian ini dimulai pada awal bulan Oktober 2017 sampai bulan Februari 2018. Sumber bahan tanam berupa tunas dari rimpang tanaman kunyit. Sumber eksplan atau bahan tanam berasal dari lapangan yang dikoleksi di Laboratorium Kultur Jaringan Teknologi Benih, Fakultas Pertanian, Universitas Padjadjaran. Eksplan diambil dari mata tunas rimpang dengan ukuran 0,6-2,0 cm. Percobaan menggunakan Rancangan Acak Lengkap yang dianalisis menggunakan metode Student’s T-test. Jumlah kelompok eksperimen dan kontrol dalam penelitian ini adalah tujuh kelompok. Variasi perlakuan dengan penambahan konsentrasi BAP, thidiazuron, zeatin, dan NAA yang berbeda pada setiap kelompok. Hasil penelitian ini menunjukkan bahwa Thidiazuron 1 mgL-1 + NAA 1 mgL-1 memberikan hasil yang lebih baik pada persentase eksplan hidup dan jumlah tunas pada tanaman kunyit (Curcuma domestica Val.) klon 41 pada umur 14 MST (Minggu Setelah Tanam).
THE EFFECT OF PARTICLE SIZE OF VOLCANIC ASH AND PHOSPHATE ROCK IN ANDISOL
Authors: Azizah Nur , Arifin Mahfud , Damayani Maya
Published: February 2020

This study was aimed at determining the effect of various particle sizes of volcanic ash and phosphate rock, including normal size (2mm), micron (200 µm) and nano (400 ղ m) on available P, P retention, delta pH and leaf area of tea plant seeds in Ciater PTPN XII Tea Plantation, West Java. The study was carried out in December 2017 until February 2018. The soil analysis was carried out at the Integrated Testing Laboratory, Vegetable Crops Research Institute, Lembang, West Java. The manufacture of micron and nano volcanic ash and phosphate rock particles was carried out at the Nanotechnology and Graphine Laboratory, Mathematics and Science Faculty, Padjadjaran University and at Tekmira Research Center, Bandung. The research design used was a Randomized Block Design (RBD) consisting of 10 treatments of the combination of volcanic ash and phosphate rocks which were repeated three times. The results show that there is a significant effect of volcanic ash and phosphate rocks of normal size to a decrease in P retention of up to 42.87%. The combination of the treatment of normal-sized volcanic ash and nano-sized phosphate rocks has a significant effect on the total leaf area of the Gambung 7 clone plant, but it did not significantly affect the available P and delta pH.PENGARUH UKURAN PARTIKEL ABU VULKANIK DAN BATUAN FOSFAT PADA ANDISOLPenelitian ini bertujuan untuk mengetahui pengaruh pemberian berbagai ukuran partikel abu vulkanik dan batuan fosfat, meliputi ukuran normal (2mm), mikron (200 µm) dan nano (400 ղm) terhadap P tersedia, retensi P, delta pH dan luas daun bibit tanaman teh di Perkebunan Teh PTPN XII Ciater, Jawa Barat. Penelitian lapangan dilaksanakan pada Desember 2017 sampai Februari 2018. Analisis tanah dilakukan di Laboratorium Penguji Terpadu, Balai Penelitian Tanaman Sayuran, Lembang, Jawa Barat. Pembuatan partikel mikron dan nano abu vulkanik dan batuan fosfat dilakukan di Laboratorium Nanoteknologi dan Graphine, Fakultas MIPA, Universitas Padjadjaran dan di Puslitbang Tekmira, Bandung. Rancangan penelitian yang digunakan adalah Rancangan Acak Kelompok (RAK) yang terdiri atas 10 perlakuan kombinasi ukuran abu vulkanik dan batuan fosfat yang diulang sebanyak tiga kali. Hasil penelitian ini menunjukkan bahwa terdapat pengaruh nyata pemberian abu vulkanik dan batuan fosfat yang berukuran normal terhadap penurunan retensi P hingga 42,87%. Kombinasi perlakuan abu vulkanik berukuran normal dan batuan fosfat berukuran nano berpengaruh nyata terhadap total luas daun tanaman teh klon Gambung 7, tetapi tidak berpengaruh nyata terhadap P tersedia dan delta pH.
THE EFFECT OF BLADE NUMBER AND WATER VELOCITY TOWARD THE PERFORMANCE OF HELIKS GORLOV TURBINE
Authors: Pranio Jeri , Karnowo Karnowo
Published: February 2020

This study was aimed at determining the influence of the number of blades and water velocity on the performance of vertical axis water turbine type Helical Gorlov. The method used was an experimental method. The descriptive analysis method was also used to analyze the data. The data obtained were in the form of variations of blades number and water velocity. The variations in the number of blades used were 2 blades, 3 blades, and 4 blades. While water velocity variations used were 0.81 m / s, 0.94 m / s, 1.08 m / s, and 1.18 m / s. The parameters were used to measure the amount of current and voltage produced by the multimeter and the number of rotations per minute (rpm) of the turbine produced by the tachometer. The results show that the number of blades and water velocity affected the performance of the Gorlov helical water turbine. The most optimal Gorlov helical turbine based on the results of research with the highest power coefficient (Cp) value is a turbine with 2 blades at a water velocity of 0.94 m/s which produces a Cp value of 0.00376 and a TSR value of 1.35.PENGARUH JUMLAH SUDU DAN KECEPATAN AIR TERHADAP KINERJA TURBIN AIR SUMBU VERTIKAL TIPE HELIKS GORLOVPenelitian ini bertujuan untuk pengaruh jumlah sudu dan kecepatan air terhadap kinerja turbin air sumbu vertikal tipe Heliks Gorlov. Metode yang digunakan dalam penelitian ini adalah eksperimen. Penelitian ini menggunakan analisis deskriptif.Data yang duperoleh berupa variasi jumlah sudu dan variasi kecepatan air. Variasi jumlah sudu yang digunakan adalah 2 sudu, 3 sudu, dan 4 sudu. Variasi kecepatan air yang digunakan yaitu 0,81 m/s, 0,94 m/s, 1,08 m/s, dan 1,18 m/s. Parameter dalam penelitian ini yang digunakan untuk menentukan kinerja adalah mengukur besarnya arus dan tegangan yang dihasilkan multimeter dan banyaknya rotasi per menit (rpm) dari turbin yang dihasilkan tachometer.Hasil penelitian menunjukkan bahwa jumlah sudu dan kecepatan air mempengaruhi kinerja turbin air heliks gorlov. Kedua, kecepatan air mempengaruhi kinerja turbin air heliks gorlov.Turbin heliks Gorlov paling optimal berdasarkan hasil penelitian dengan nilai koefisien daya (Cp) tertinggi yaitu turbin dengan 2 sudu pada kecepatan air 0,94 m/s yang menghasilkan nilai Cp sebesar 0,00376 dan nilai TSR 1,35.
THE EFFECT OF OPENING TYPE ON THERMAL CONVENIENCE OF THE OLD AND NEW BUILDING CLASSROOM
Authors: Senoaji Ali Anton , Kusumawanto Arif , Utami Sentagi Sesotya
Published: February 2020

This study was aimed at analyzing the effect of opening type on the thermal convenience of classrooms in old and new buildings at SMK Negeri 3 Yogyakarta. This study used a qualitative comparative method and the simulation of IES VE 2018. The field air measurement is carried out at 10 measurement points and 5 measurement points in each class, with a height of 1.5 m. Field measurements were carried out in March 2019, at 06.30-16.30 WIB. The parameters used in the study were air temperature, humidity and wind speed. Air temperature and humidity were measured using a Thermo hygrometer. Wind speed was measured using an anemometer. The data collection method is carried out by observation and measurement. Root Mean Squared Error (RMSE) was used to validate the data. The results show the best thermal convenience of the classroom was obtained during the simulation using the type of Windows Awning, with a full aperture area. Simulation results show a comfortable distribution of airflow in the classroom at wind speeds above 0.15-0.28 m/sec, Temperature 25.07-27.10oC.PENGARUH TIPE BUKAAN TERHADAP KENYAMANAN TERMAL RUANG KELAS BANGUNAN LAMA DAN BARU Tujuan dari penelitian yaitu menganalisis pengaruh bukaan terhadap kenyamanan termal ruang kelas pada bangunan lama dan baru, di SMK Negeri 3 Yogyakarta. Penelitian ini menggunakan metode komparatif kualitatif yaitu dan hasil simulasi IES VE 2018. Pengukuran udara luar dilakukan pada 10 titik pengukuran dan sebanyak 5 titik pengukuran disetiap kelasnya, dengan ketinggian 1,5 m. Pengukuran lapangan dilakukan pada bulan Maret tahun 2019, waktu 06.30-16.30 WIB. Parameter yang digunakan dalam penelitian yaitu temperatur udara, kelembaban dan kecepatan angin. Temperatur udara dan kelembaban diukur dengan menggunakan alat thermo hygrometer. Kecepatan angin diukur dengan menggunakan alat anemometer. Metode pengumpulan data dilakukan dengan metode pengamatan dan pengukuran. Validasi data menggunakan Root Mean Squared Error (RMSE). Hasil penelitian menunjukkan kenyamanan termal ruang kelas terbaik diperoleh pada saat simulasi menggunakan tipe bukaan ke atas atau Awning Windows, dengan area bukaan penuh. Hasil simulasi menunjukkan distribusi aliran udara yang nyaman di dalam ruang kelas pada kecepatan angin di atas 0,15-0,28 m/det, Temperatur 25,07 -27,10o C.
THE RELATIONSHIP AMONG PEDICULOSIS CAPITIS, ANEMIA AND LEARNING ACHIEVEMENT IN ELEMENTARY STUDENTS
Authors: Sulistyani Nunung , Khikmah Nur
Published: February 2020

This study was aimed at determining the relationship between the Pediculus humanus capitis infestation condition, anemia status and learning achievement in primary school-age children. This study was conducted at SD Bangunharjo Sewon Bantul, Yogyakarta. This study is an observational analytic study with cross sectional design in which the variables are measured in one measurement without intervening. The data obtained through pediculosis examination, Hb examination, and measurement of learning outcomes. The data then were analyzed descriptively presented in tabular form, then performed statistical analysis using the chi-square test. The results show that the students suffering from pediculosis, 57.9% also suffering from anemia and 51.0% having poor category achievement. In line with other researchers, one of the factors that influence one’s learning achievement is the memory factor. Someone’s anemia status can affect one’s memory. The prevalence of Pediculus humanus capitis infestation is 38.3%. Chi-square test showed a significant relationship between Pediculus humanus capitis infestation condition, anemia status, and learning achievement.HUBUNGAN PEDIKULOSIS KAPITIS, STATUS ANEMIA DAN PRESTASI BELAJAR PADA SISWA SEKOLAH DASAR Penelitian ini bertujuan untuk mengetahui hubungan kejadian infestasi Pediculus humanus capitis (kutu kepala) dengan status anemia dan prestasi belajar pada anak usia sekolah dasar. Penelitian ini dilakukan di SD wilayah Bangunharjo Sewon Bantul Yogyakarta. Penelitian ini merupakan penelitian analitik observasional dengan desain cross sectional. Variabel diukur dalam satu kali pengukuran dengan tidak melakukan intervensi. Data penelitian diperoleh melalui pemeriksaan pedikulosis, pemeriksaan Hb, dan pengukuran hasil belajar. Data dianalisa secara deskriptif yang disajikan dalam bentuk tabel, kemudian dilakukan analisis statistik menggunakan Uji chi-square. Hasil penelitian ini menunjukan bahwa menderita pedikulosis sebesar 57,9% menderita anemia dan sebesar 51,0% dengan prestasi belajar kategori kurang baik. Salah satu faktor yang mempengaruhi prestasi belajar seseorang yaitu faktor daya ingat. Status anemia seseorang dapat mempengaruhi daya ingat seseorang. Prevalensi infestasi Pediculus humanus capitis sebesar 38,3%. Uji chi-square menunjukkan adanya hubungan yang signifikan antara kejadian infestasi Pediculus humanus capitis dengan status anemia dan prestasi belajar.
The role of marketing intelligence system in achieving customer happiness
Authors: Hemeh Ameen Yousif Obed , Moheden Nishteman Othman
Published: February 2020

The objective of this study is to measure the nature of the relationship between research variables including the dimensions of marketing intelligent system and customer size. The study investigates whether marketing intelligent system plays the role in obtaining customer happiness in business organizations. The study tried to measure the relationship between marketing intelligence system and its dimension against customer happiness in the given organizations. It also aims to identify the impacts of moral factor of marketing intelligent system and its dimensions on customer happiness. To test given hypotheses, the study used a number of statistical analysis methods such as repetitions, percentages, arithmetic mean, standard deviation, correlation coefficient, and simple linear regression coefficient. The findings indicated that there is a strong positive relationship between marketing intelligence and customer happiness. The study also identified a strong positive correlation between moral factors of marketing intelligence and customer happiness.  The study concluded that organizations should take full consideration to the factors that delights customers. Finally, the study recommends that organizations should work through employees to cultivate a culture of customer happiness.
Keywords - Marketing Intelligence, Marketing Intelligence Dimensions, Customer Happiness, Five Star Hotels, Sulaymaniyah City
Internet Use, Depression, and Anxiety in a Healthy Adolescent Population: Prospective Cohort Study
Authors: Thom Robyn Pauline , Bickham David S , Rich Michael
Published: February 2020

Background

Psychiatric disorders, including conduct disturbances, substance abuse, and affective disorders, emerge in approximately 20% of adolescents. In parallel with the rise in internet use, the prevalence of depression among adolescents has increased. It remains unclear whether and how internet use impacts mental health in adolescents.

Objective

We assess the association between patterns of internet use and two mental health outcomes (depression and anxiety) in a healthy adolescent population.

Methods

A total of 126 adolescents between the ages of 12 and 15 years were recruited. Participants reported their typical computer and internet usage patterns. At baseline and one-year follow-up, they completed the Beck Depression Index for primary care (BDI-PC) and the Beck Anxiety Inventory for Primary Care (BAI-PC). Individual linear regressions were completed to determine the association between markers of internet use at baseline and mental health outcomes at one-year follow-up. All models controlled for age, gender, and ethnicity.

Results

There was an inverse correlation between minutes spent on a favorite website per visit and BAI-PC score. No association was found between internet use and BDI-PC score.

Conclusions

There is no relationship between internet use patterns and depression in adolescents, whereas internet use may mitigate anxiety in adolescents with higher levels of baseline anxiety.
Web-Based Virtual Learning Environment for Medicine Administration in Pediatrics and Neonatology: Content Evaluation (Preprint)
Authors: Pereira Alayne Larissa Martins , Leon Casandra Genoveva Rosales Martins Ponce , Ribeiro Laiane Medeiros , Brasil Guilherme Da Costa , Carneiro Karen Karoline Gouveia , Vieira Géssica Borges , Barbalho Yuri Gustavo De Sousa , Silva Izabel Cristina Rodrigues Da , Funghetto Silvana Schwerz
Published: February 2020

BACKGROUND

Worldwide, patient safety has been a widely discussed topic and has currently become one of the greatest challenges for health institutions. This concern is heightened when referring to children.

OBJECTIVE

The goal of this study was to develop a virtual learning environment for medication administration, as a tool to facilitate the training process of undergraduate nursing students.

METHODS

Descriptive research and methodological development with a quantitative and qualitative approach were used with stages of design-based research as methodological strategies. For the development of the virtual environment, 5 themes were selected: rights of medication administration, medication administration steps, medication administration routes, medication calculation, and nonpharmacological actions for pain relief. After development, 2 groups—expert judges in the field of pediatrics and neonatology for environment validation and undergraduate nursing students for the assessment—were used to assess the virtual learning environment. For the validation of the virtual learning environment by expert judges, the content validity index was used, and for the evaluation of the students, the percentage of agreement was calculated.

RESULTS

The study included 13 experts who positively validated the virtual environment with a content validity index of 0.97, and 26 students who considered the content suitable for nursing students, although some adjustments are necessary.

CONCLUSIONS

The results show the benefit of the virtual learning environment to the training of nursing students and professional nurses who work in health care. It is an effective educational tool for teaching medication administration in pediatrics and neonatology and converges with the conjectures of active methodologies.
Kinematic lab susp: a mobile app that quantifies exercise with suspension devices. Theoretical aspects of development. (Preprint)
Authors: López-Moranchel Ignacio , Maurelos-Castell Patricia , Picó Pérez Vicent , Ara Ignacio , Alegre Luis Mª
Published: February 2020

UNSTRUCTURED

After carrying out a bibliographic review of the different ways of estimating the load during suspension training, this study describes the theoretical foundations of the development of a mobile phone application (Kinematic lab susp) that allows estimating the load mobilized when training with devices in suspension (type TRX ®). Methods: systems of equations are proposed whose terms depend on the angulation of the device with respect to the vertical (angle α), the relationship between the height of grip and the height of the center of mass, and the weight of the subject that are recorded by means of a photograph. Results: after taking a photograph and incorporating the height of the subject, the application allows measuring the angle α, providing values of applied force (in N) and mobilized load in relation to the percentage of body mass applying the calculations described in our equations. The study also provides the estimated value of the load mobilized during a push on the floor (68% of the subject's body mass) and the equation for the calculation of the mobilized load when the suspension device is fixed to the feet. Conclusions: it is possible to estimate by means of equations the load mobilized in each repetition during the training by suspenesion devices. Kinemtaic lab susp is the first mobile app that allows this calculation to be made from the taking of a photograph.
Automated Identification of Common Disease-Specific Outcomes for Comparative Effectiveness Research Using ClinicalTrials.gov: Algorithm Development and Validation Study (Preprint)
Authors: Elghafari Anas , Finkelstein Joseph
Published: February 2020

BACKGROUND

Common disease-specific outcomes are vital for ensuring comparability of clinical trial data and enabling meta analyses and interstudy comparisons. Traditionally, the process of deciding which outcomes should be recommended as common for a particular disease relied on assembling and surveying panels of subject-matter experts. This is usually a time-consuming and laborious process.

OBJECTIVE

The objectives of this work were to develop and evaluate a generalized pipeline that can automatically identify common outcomes specific to any given disease by finding, downloading, and analyzing data of previous clinical trials relevant to that disease.

METHODS

An automated pipeline to interface with ClinicalTrials.gov’s application programming interface and download the relevant trials for the input condition was designed. The primary and secondary outcomes of those trials were parsed and grouped based on text similarity and ranked based on frequency. The quality and usefulness of the pipeline’s output were assessed by comparing the top outcomes identified by it for chronic obstructive pulmonary disease (COPD) to a list of 80 outcomes manually abstracted from the most frequently cited and comprehensive reviews delineating clinical outcomes for COPD.

RESULTS

The common disease-specific outcome pipeline successfully downloaded and processed 3876 studies related to COPD. Manual verification indicated that the pipeline was downloading and processing the same number of trials as were obtained from the self-service ClinicalTrials.gov portal. Evaluating the automatically identified outcomes against the manually abstracted ones showed that the pipeline achieved a recall of 92% and precision of 79%. The precision number indicated that the pipeline was identifying many outcomes that were not covered in the literature reviews. Assessment of those outcomes indicated that they are relevant to COPD and could be considered in future research.

CONCLUSIONS

An automated evidence-based pipeline can identify common clinical trial outcomes of comparable breadth and quality as the outcomes identified in comprehensive literature reviews. Moreover, such an approach can highlight relevant outcomes for further consideration.
WELFARE IMPACT OF HIGH-NUTRIENT FOOD PRICE INCREASE ON INDONESIAN HOUSEHOLDS: IS THERE ROLE FROM OWN-FARM PRODUCTION?
Authors: Umaroh Rodhiah , Pangaribowo Evita Hanie
Published: February 2020

Introduction/Main Objectives: Significant price increases of food commodities and uncertainty in the market probably have a severe impact on society and especially on the low-income households in it. Background Problems: The increases in food price could have a large impact on the economy and specifically on that of households. Thus, the study was conducted to investigate what the demand for food specifically high-nutrient food and the impact on welfare are like in Indonesian households when food prices rise. Novelty: There were bulk of empirical researches on the impact of food price changes on household welfare, however the study focused on high-nutrient commodities in particular on the self-produced food was still limited. many of the previous studies used cross-section data for one period but this study used two-wave longitudinal data Research Methods: Using large sample data from Indonesian Family Life Survey (IFLS), the study employed the Quadratic Almost Ideal Demand System (QUAIDS) to identify the demand pattern and applied Compensating Variation (CV) to understand the impact of soaring food price on welfare change Finding/Results: Overall, The analysis of welfare impact notes that when the price increases, all household groups would experience welfare loss. The poorest household would be lower in level of experiencing welfare loss than the richest household while more welfare loss is suffered by households that live in Java and rural areas. Conclusion: For the low-income households, having their own productive farm could overcome an economic shock threatening them. Thus, the government should support small-scale farming through such strategic policies as giving them input assistance and training in how to manage a small farm.m.