bluuebunny/crossref_metadata_2025 huggingface dataset:
Traditional Chinese Medicine Pattern Classification and Herbal Medicine for COVID-19
Authors: Gao Zhen , Liu Ying-Ying , Chen Ye-Meng , Dong Jing-Cheng
Published: July 2022

Background:

Traditional Chinese medicine (TCM) plays a crucial role in the prevention and control of coronavirus disease 2019 (COVID-19).

Objective:

The study aimed to reveal the distribution characteristics of COVID-19 TCM syndrome types and syndrome elements and the law of TCM treatment and medication.

Methods:

The TCM diagnosis and treatment protocol for COVID-19 and clinical research data were obtained through network retrieval, and Revman 5.3 and SPSS 23.0 were employed to analyze the composition of TCM syndromes and the situation of TCMs in meta and frequency.

Results:

The top three TCM syndromes of COVID-19 included damp-heat accumulation in the lung pattern, damp abundance due to spleen deficiency, and epidemic toxin invading the lung pattern, while the syndrome elements were dampness, heat, and toxin. Gypsum fibrosum, Pogostemonis herba, and Armeniacae semen were identified as the commonly used drugs. Different syndrome elements were identified at lung disease location: Forsythiae fructus, Glycyrrhizae radix, and Armeniacae semen can be used for “wind;” Glycyrrhizae radix, Armeniacae semen, and Scutellariae radix can be used for “Heat;” Armeniacae semen, Sheng Gypsum fibrosum, and Ephedrae herba can be used for “Toxin;” Ephedrae herba, Armeniacae semen, and Atractylodis rhizome can be used for “Damp;” Magnoliae officinalis Cortex, Ephedrae herba, and Zingiberis Rhizoma recens can be used for “cold;” and Armeniacae semen, Gypsum fibrosum, Ephedrae herba, and Lepidii/Descurainiae semen can be used for “epidemic.”

Conclusion:

The establishment of a treatment scheme based on the classification of disease syndrome elements should be considered for sudden infectious diseases, such as COVID-19. Pogostemonis herba, Armeniacae semen, Gypsum fibrosum, and Glycyrrhizae radix should be considered as effective drugs from TCM for the treatment of COVID-19.
Sexual Dysfunction in Women with Type 2 Diabetes Mellitus
Authors: Gupta Manisha , Shukla Rishi , Verma Shivendra , Kalhan Atul
Published: July 2022

Introduction:

There is a dearth of studies evaluating sexual dysfunction in women with Type 2 Diabetes Mellitus (T2DM), despite anecdotal evidence suggesting an association between glycemic control and female sexual health.

Materials and Methods:

An observational cross-sectional study was carried out in 100 women with T2DM under follow-up at a regional diabetes center. Validated questionnaires, Female Sexual Function Index (FSFI), and Female Sexual Distress Scale (FSDS) were used to collate the prevalence and severity of female sexual dysfunction (FSD) in the subjects. Anthropometric and metabolic parameters were recorded by clinical examination and blood tests, respectively.

Results:

FSD was reported in 18% (95% CI: 10.5–25.5%) of the women enrolled in the study. The women with FSD were significantly older (50 ± 9.3 years vs. 43.9 ± 8.2 years, P = 0.006). In addition, the mean body mass index (BMI) (31.96 ± 5.5 Kg/m2 vs. 28.98 ± 4.63Kg/m2, P = 0.02) and waist circumference (38.88 ± 6.6 inches vs. 35.54 ± 5.62 inches, P = 0.03) were higher in the women with FSD compared with those without FSD. However, we observed no statistically significant association between FSD and the duration of diabetes, level of glycemic control, and serum testosterone level.

Conclusion:

Advanced age, higher BMI, and central adiposity were related with the development of FSD, whereas the duration of diabetes and level of HbA1c did not increase FSD risk.
Comparing Time to Intensification between insulin Degludec/Insulin Aspart and Insulin Glargine
Authors: Kovil Rajiv
Published: July 2022

Background and Aims:

The objective of the study was to compare the percent of patients with type 2 diabetes (T2D) requiring dose intensification and the time to dose intensification in patients on insulin degludec/insulin aspart (IDegAsp) versus those on basal insulin.

Materials and Methods:

Data were collected through retrospective chart review of patients with T2D being treated with insulin at a single center in India. The increase from once daily (OD) to twice daily dose or the addition of prandial insulin was considered as dose intensification. Chi-square test was conducted to compare the groups.

Results:

In the IDegAsp group (n = 515), 455 patients continued on the OD dose, and 60 patients (11.6%) were intensified. In the insulin glargine (IGlar) group (n = 173), 143 patients remained on the initial dose and 30 patients (17.34%) were intensified. Fewer patients on IDegAsp required treatment intensification than those on IGlar (P = 0.05). The time to treatment intensification (±standard deviation) was 11.98 ± 7.81 months in the IDegAsp group and 6.71 ± 6.86 months in the IGlar group. The time to treatment intensification was significantly longer in the IDegAsp than in the IGlar group (P = 0.0023).

Conclusions:

The study shows that significantly fewer patients on IDegAsp required dose intensification than those on IGlar. Additionally, the time to dose intensification was significantly delayed in patients on IDegAsp as compared to IGlar. However, HbA1c reduction with IGlar (nonintensified) was significant only at 6 months and failed to reach significance at 12 months, thereby pointing toward an early need for treatment intensification.
Pattern of Presentation in a Community Outpatient Wound Clinic
Authors: Iyun Ayodele Olukayode , Iyun Omobolaji Ibukun
Published: July 2022

Introduction:

The management of patients with cutaneous wounds entails both inpatient and outpatient care. There is scarcity of dedicated community wound clinics in Nigeria to guarantee appropriate management of especially difficult-to-heal wounds on outpatient basis. The aim of the study was to describe the pattern of presentation of patients with wounds at a community outpatient wound clinic (COWC).

Materials and Methods:

Consecutive patients with wounds who presented to a COWC in the city of Ibadan from October 2015 to December 2021 were included. Descriptive analysis was done using IBM® SPSS® Statistics 21.

Results:

Two hundred and forty-four patients with wounds presented at the wound clinic. There was a slight female preponderance of 52%. Almost one-tenth of the patients were 80 years old and above. Post-traumatic wounds were the commonest type of wounds accounting for 15.3% of the patients seen. This was followed by diabetic wounds (14.9%) and haemoglobinopathic (sickle cell) wounds (13.2%). In patients with leg wounds who presented during the period, diabetic wounds (24.4%) was the commonest aetiology, haemoglobinopathic leg wounds accounted for 23% of patients, and post-traumatic leg wounds were seen in 20% of the patients.

Conclusion:

COWC is an option to managing complex wounds from various aetiology. Best practices in wound care will result in more favourable outcome in difficult-to- heal wounds and early referrals from wound clinics for limb salvaging procedures are additional benefits.
Glycerolised Skin Allografts for Extensive Burns in Low- and Middle-income Countries
Authors: Iyun Ayodele Olukayode , Ademola Samuel Adesina , Olawoye Olayinka A. , Michael Afieharo I. , Aderibigbe Rotimi Opeyemi , Iyun Omobolaji Ibukun , Oluwatosin Odunayo M.
Published: July 2022

Introduction:

There has been a significant improvement in the outcome of treatment of large surface area burns in developed countries. A major contributory factor is an early excision and skin grafting of burn wounds. The initial coverage of large surface area deep burn wounds requires the use of temporary skin substitutes such as allografts due to limited skin autografts. Cadaveric skin allografts are the commonest source of skin allografts in use; however, there may be religious, cultural, cost, or other factors mitigating its availability and routine use in low- and middle-income countries (LMICs). Human skin allografts may be used fresh or stored in tissue banks to ensure its ready availability. The purpose of this review is to promote glycerolised skin allografts as a means of skin preservation in low-resource countries above other modalities cryopreservation due to its cost advantages and relative ease of operation.

Materials and Methods:

A literature search for articles related to human skin allograft use in burn care, skin banks, and glycerolised skin allografts in LMICs was done using PubMed, EMBASE, and Web of Science databases. The key words used were ‘allograft’ and ‘burn’ with a filter in the search for human studies. The relevant references in the articles obtained were also searched for and included in the review

Results:

Sixty-three journal articles were reviewed for contents in line with the objectives of this study.

Conclusion:

Glycerolised skin graft is a viable option for coverage of extensive burns in LMICs.
Correlation between presence of Lumbar Instability, Physical function and Balance in subjects with knee osteoarthritis
Authors: Bhatt Urmi , Shukla Yagna
Published: July 2022

BACKGROUND AND OBJECTIVES:

Osteoarthritis (OA) of the knee is one of the most common musculoskeletal disorders that increase the global health burden. Various research aimed to improve pain and physical functions in individuals with OA knee have been conducted. However, there is a dearth of research evaluating coexisting lumbar instability and its impact on physical function limitation and risk of fall in individuals with knee OA, while there is a pool of research on kinetic chain evaluation including lumbar spine for the athletic population for injury prevention.

METHODOLOGY:

Twenty-two individuals with OA knee, aged 50–65 years (male or female) willing to participate in the study were included in the study. Demographic details including age, body mass index (BMI), and duration of knee pain were recorded. All the individuals were screened for the presence of lumbar segmental instability (using passive lumbar extension test), balance (using Dynamic Gait Index), and physical function using mWOMAC.

RESULTS:

Data were analyzed using SPSS. There were significantly greater (P < 0.05) deficits in balance and function of individuals with the presence of clinical lumbar segmental instability. In addition, BMI and duration of knee pain also correlated positively with balance and function deficits in all individuals.

CONCLUSION:

The presence of lumbar segmental instability in individuals with OA knee puts them at greater risk of falls due to altered balance and limits functional ability as well.
Narrative review on effects of physical training on risk of cardiometabolic diseases
Authors: Rai Richa Hirendra , Mehta Vishal , Sakshi  , Asif Mohd , Goyal Kajal , Balodhi Apoorva , Manglik Palak
Published: July 2022

Cardiometabolic diseases as defined by various expert bodies are a varied range of noncommunicable diseases that have slowly creeped in the community by inducing a dreadful combination of central adiposity, reduced insulin sensitivity, hypertension, and dyslipidemia which lead to cardiometabolic diseases, diabetes, renal disorders, and/or metabolic syndrome (MetS). Several authors have brought it to notice that alterations in lifestyle and environment leading to the disruption of circadian rhythm trigger the pathophysiology leading to the development of multiple risk factors and cardiometabolic diseases. Statements very critically state that though MetS cannot be considered as an absolute risk indicator, patients with it are twice at the risk of developing cardiac ailment and at five times the risk of developing insulin-resistant diabetes in the near future. Collaboratively, be it WHO statement of 1999, “the National Cholesterol Education Program ATP3 2005,” or further ratification by “the International Diabetes Federation” 2006, “the American Association of Clinical Endocrinologist” 2003, “European Group for the study of Insulin Resistance,” “the European Society of Cardiology,” and the American College of Cardiology American Heart Association as discussed in this brief review, all are continuously insisting on prevention and conducting awareness programs for the same. The electronic database (PubMed/MEDLINE, Embase, etc.,) was searched for available literature on different guidelines for exercise prescription (Frequency, Intensity, Time, Type [FITT]) in January–April 2021. After reviewing the literature by different authors, a brief review was conceptualized from the same. The different protocols suggested for health and fitness by different guidelines have been presented here with the effect of physical activity discussed with literature support with respect to physiology, prevention, prophylaxis, and treatment. The burden of lifestyle disorders is increasing tremendously and is also increasing the economic cost on society. It is high time that we understand the seriousness and start observing the well-stated advice offered by several guidelines over many years and stay physically active.
Comparison of effectiveness of electrical stimulation, myofascial release, and conventional physiotherapy over acupuncture points (GB21, SI14) on upper trapezius in female basketball players
Authors: Jha Sanjiv , Bajpai Sanket , Mishra Ruchi , Brahm Vaishali , Bhargava Ananya
Published: July 2022

AIM:

The aim of the study is to compare the effectiveness of electrical stimulation, myofascial release (MFR), and conventional physiotherapy over acupuncture points (GB21, SI14) on the upper trapezius in female basketball players.

METHODOLOGY:

The study included 30 patients with unilateral myofascial trigger points (MTrPs) present on acupuncture points GB2l (midway between shoulder and vertebral column) and SI14 (3 cm lateral to lower border of spinous process of first thoracic vertebra) on the upper trapezius, between the age group of 18 and 30 years. The patients were allotted alternatively to Group A, Group B, and Group C, respectively. Preparticipation evaluation was done. Group A received electrical stimulation with exercise, Group B received MFR with exercise, and Group C received cold pack with exercise. Posttreatment evaluation is conducted on the 7th day of treatment.

RESULTS:

The results showed that Group B has significant decrease in pain and increase in lateral bending of the cervical spine to the opposite side at posttest values as compared to Group A and Group C.

CONCLUSION:

All three groups have got beneficial effects in reducing pain intensity and increasing lateral bending of the cervical spine to the opposite side. Group B shows more significant effect in decrease in pain and increase in lateral bending of the cervical spine to the opposite side in female basketball players with MTrP over acupoints GB21, SI14 on the upper trapezius.
Normal limit law for protected node profile of random recursive trees
Authors: Toofanpour Jaleh , Javanian Mehri , Imany-Nabiyyi Ramin
Published: July 2022

Защищенные вершины, т.е. вершины с расстоянием не менее $2$ до ближайшего листа, были изучены для различных классов случайных корневых деревьев. В предложенной статье исследуется профиль защищенных вершин, т.е. количество защищенных вершин, находящихся на фиксированном расстоянии от корня в случайном рекурсивном дереве. В случае, когда отношение указанного расстояния к логарифму размера дерева стремится к нулю, мы находим асимптотические представления для математического ожидания, дисперсии и ковариации между профилями защищенных и незащищенных вершин в случайных рекурсивных деревьях. Мы также показываем, используя двумерную характеристическую функцию и сингулярный анализ, что совместное распределение профилей защищенных и незащищенных вершин является в пределе двумерным нормальным распределением.
A Gibbs conditional theorem under extreme deviation
Authors: Biret Maeva , Broniatowski Michel , Cao Zangsheng
Published: July 2022

Исследуются некоторые свойства условного распределения выборки из независимых одинаково распределенных случайных величин при условии очень больших значений ее суммы. Мы контролируем пороги для асимптотической независимости слагаемых - в отличие от классического случая, когда событие, относительно которого рассматривается условное распределение, принадлежит области больших уклонений. Настоящая работа является продолжением статьи второго и третьего авторов 2014 г. Используемые инструменты включают в себя новое разложение Эджворта для специальной схемы серий, когда серии порождаются скошенным распределением с расходящимися параметрами, а также некоторые результаты абелева типа.
Driving and Inhibiting Factors for Digital Transformation and Their Effects over the Advent of The Covid-19 Pandemic
Authors: Salume Paula Karina , Cintra Leandro Pinheiro , Silva Leandro Libério da
Published: July 2022

This paper aims to investigate driving and inhibiting factors for Digital Transformation (DT) and their effects on the advent over the COVID-19 pandemic from the perspective of business consultants.
The research has been presented as descriptive in nature as well as on its general objective and on its approaching form, which come classified along as qualitative aspects. From the field of an investigation, four key dimensions emerged as the most relevant technology for DT: the value creation, the organizational structure and the culture adopted on businesses. Furthermore, it is worth highlighting the role of leadership as a key element in driving the team during a journey which requires a cultural transformation linked to DT.
Wheelchair Axle Position Effect on the Propulsion Performance of Persons With C7 Tetraplegia: A Repeated-Measures Study
Authors: Freixes Orestes , Fernández Sergio Anibal , Passuni Diego Alejandro , Gatti Marcelo Andrés , Buffetti Eliana , Rivas Maria Elisa , Olmos Lisandro Emilio , Crespo Marcos José
Published: July 2022

Objectives

To assess the changes in speed, stroke frequency, acceleration, and shoulder range of motion (ROM) associated with different wheelchair axle positions in people with chronic C7 tetraplegia.

Methods

This repeated-measures study was conducted at the Chronic Spinal Cord Injury Unit, FLENI Escobar, Argentina. The speed, stroke frequency, acceleration, and shoulder ROM during wheelchair propulsion were measured in nine participants with C7 spinal cord injury (SCI) in four different axle positions (forward and up, forward and down, backward and down, backward and up). Two strokes performed at maximum speed were analyzed on a smooth level vinyl floor in a motion analysis laboratory. Data were analyzed for significant statistical differences using the Friedman test and the Wilcoxon signed rank test.

Results

Our study showed significant differences in the speed with axle position 1 (1.57 m/s) versus 2 (1.55 m/s) and position 2 (1.55 m/s) versus 4 (1.52 m/s). The shoulder ROM showed a significant difference in the sagittal plane in position 2 (59.34 degrees) versus 3 (61.64 degrees), whereas the stroke frequency and the acceleration parameters showed no statistically significant differences with the different rear axle positions.

Conclusions

Our study showed that modifying the rear axle position can improve the propulsion speed and produce changes in the shoulder ROM in the wheelchair propulsion of individuals with C7 SCI.
CRONOLOGIA DA INVASÃO DO PEIXE-LEÃO Pterois spp. NO ATLÂNTICO OCIDENTAL
Authors: Cintra Israel , Martins Déborah , Klatau Alex , Carvalho Marina , Barbosa José Milton
Published: July 2022

The lionfish Pterois spp., native from the warm and tropical waters of the South Pacific and Indian Ocean, including the Red Sea, is currently present from the US coast to Brazil. The lionfish is an example of successful invasion and it is the first non-native marine fish to settle along the entire western coast of the Atlantic Ocean, including Fernando de Noronha. So, we present chronological information about the lionfish invasion at Western Atlantic and Brazil.
Seguridad y calidad oncológica de la cirugía por cáncer colorrectal en un centro docente universitario
Authors: Liz Alejandra , Castro Alvaro , Soumastre Alejandro , Lavega Álvaro , Fagúndez Natalia , Viola Malet Marcelo
Published: July 2022

Introducción: Es fundamental que cada equipo quirúrgico audite la calidad de sus cirugías, mas en un centro docente, el cual debe garantizar el correcto aprendizaje de la cirugía oncológica.

Objetivo: evaluar la calidad de la cirugía oncológica por cáncer colorrectal en un centro universitario.

Material y métodos: estudio retrospectivo sobre una base de datos prospectiva de pacientes operados por cáncer colorrectal en el hospital Pasteur, entre 2017-2021. Se analizó la seguridad de la cirugía, la calidad oncológica de la resección y el nivel formativo del cirujano principal.

Resultados: de los 89 pacientes, no hubo diferencias de género. La mediana de edad fue 69 años. Predominaron los pT3 (50%) y pT4 (36,5%), pN0 (60%) y pN1 (29%). Los procedimientos mas realizados fueron la colectomía derecha (43%) y la resección anterior de recto (40%). El 69% fueron laparoscópicos, con una conversión del 5%. La dehiscencia anastomótica fue 9,8%, mas frecuente en las anastomosis ileotransverso (13%) y las manuales (16%). Hubo 10% de complicaciones quirúrgicas moderadas-severas (grados 3 y 4 de Clavien-Dindo). La tasa de reintervención fue 11% y la mortalidad 2%. La mediana de internación fue 7 días. El número de ganglios resecados tuvo una mediana de 16. No hubo compromiso del margen distal y el circunferencial estuvo libre en 85%. La fascia rectal fue completa/casi completa en 93%. Casi 70% de las cirugías fue realizada por cirujanos jóvenes.

Conclusión: en nuestro centro, la cirugía por cáncer colorrectal cumple con estándares internacionales de seguridad y calidad oncológica. La mayoría de los procedimientos fueron realizados por los jóvenes, en forma tutorizada.
COMPARISON R AND CURLI METHODS FOR MULTI-CRITERIA DECISION MAKING
Authors:   Hanoi University of Industry, Faculty of Mechanical Engineering, Trung Do Duc
Published: July 2022

When multi-criteria decision making, decision makers will expend significant effort in selecting a data normalization method and a weighting method. If a mistake is made in those choices, it will result in decisions that do not find the best solution. Furthermore, with qualitative criteria, it is impossible to standardize the data. Similarly, determining the weights of criteria will be difficult if the criteria are in qualitative form. R and CURLI are two multi-criteria decision-making methods that do not require data normalization or the use of additional weighting methods for the criteria. They are therefore well suited for ranking alternatives when the criteria are both quantitative and qualitative. This study compares the two methods through three examples from different fields. The results show that these two methods jointly determine the best solution in all three fields and are also suitable when using other decision- making methods that require data normalization and have high requirements using the method of determining the weights for the criteria.
ИСКУССТВЕННЫЙ ИНТЕЛЛЕКТ И АВТОМАТИЗАЦИЯ В НАВИГАЦИИ И
СУДОХОДСТВЕ. СНИЖЕНИЕ ВЛИЯНИЯ ЧЕЛОВЕЧЕСКОГО ФАКТОРА
Authors: Гладкова А.М. , Марушевский М.В. , Фаустова О.Г.
Published: July 2022

Человеческий фактор часто является причиной катастроф и происшествий во всём

мире, и ученые уже всерьез задумываются о замене человека в скором будущем во многих

профессиональных сферах. Искусственный интеллект уже давно используется во всех

сферах человеческой жизни, и судоходство не является исключением. Эксплуатация систем в

помощи принятия решений с глубоким машинным обучением не ограничивается только

помощью в построении маршрута, но также распространяется на снижение рисков и

предотвращения столкновений в море. Базой для машинного обучения являются конвенции –

унифицированные правила, регулирующие определенные сферы судовой навигации. Однако

любая модернизация связана с определенными рисками. Данная статья ориентирована на

оценку не только подобных рисков, но и перспектив автоматизации судоходства в целом.
Why attacks on Doctors are Increasing?
Authors: Kadu Dr. Sandeep
Published: July 2022

Every day we watch or read news about patient’s or their relative’s conflicts with doctor. Hence question arises Why in recent years such incidences are increasing? I think as medical practioner we have to introspect on this issue.

As per my opinion and experience patient as well as doctors both are equally responsible for such conflicts. As we all know truth is always bitter and, in this article, I would like to point out some sensitive areas of medical practice, there can be irreconcilable difference over this discussion.
Assessment of Cardiopulmonary Resuscitation Knowledge and Attitude Amongst Interns and Junior Residents of Tertiary Care Centre
Authors: Kshirsagar Ms. Trisha , Kshirsagar Dr. Roop , Kadu Dr. Sandeep
Published: July 2022

Introduction: Cardiopulmonary resuscitation (CPR) is a life saving procedure and adequate knowledge and skills related to CPR are essential for all medical students. This study was undertaken to compare knowledge and practice related to updated CPR guidelines by American Heart Association (AHA) 2020 between junior residents and interns. Methods: This is a questionnaire-based study prepared on Google form consisting of 22 questions on CPR. The participants were all from DVVPF’s medical college and hospital, Ahmednagar and all those who were willing to participate were included. They were advised to read carefully and allowed to tick one best response among the options. Results: Total of 124 participants included 41 junior residents and 83 interns. An average overall correct response from both the group was 14.48 (65.81 %). Interns score was average of 13.024 (59.20 %) and so had lower correct response than junior residents, who had average score of 18.39 (83.59%). But there was a considerable difference in pattern of correct response between both the groups. Among theory knowledge-based questions (Part 1), junior residents had an average of 8.707 correct answers out of 11 (79.15%) which is more correct answers than interns who have average 5.90 correct (53.63%). Similarly, in terms of practical knowledge, junior residents had an average score 9.682 out of 11 (88.026%) compared to interns who had an average of 6.518 out of 11 (59.27%). Conclusion: The study showed poor knowledge about CPR among the interns.  More practical based teaching should be employed in MBBS curriculum. Periodical reinforcement and refresher courses should be part of curriculum.
Neonatal Facial Subcutaneous Abscess: A Case Report
Authors: Shinde Dr. Mahesh , Shinde Dr. Abhijit , Kumar Dr. Sushrut , Mhaske Dr. Sunil Natha , Waydande Dr. Suresh
Published: July 2022

Skin and soft-tissue infections (SSTIs) are a relatively common diagnosis in both the pediatric and adult populations and include abscesses and cellulitis. An abscess is a focal, contained, purulent infection with a clearly defined “cavity” and surrounding inflammation involving the deep subcutaneous tissues. Cellulitis is an infection of the skin, without an organized cavity, presenting with erythema, warmth, induration, and tenderness [1]. There has been a recent rise in the incidence of SSTIs, with up to 95% of this increase attributed to abscesses and cellulitis, with the largest change occurring in the pediatric (<18 years) population [2]. In addition to an overall increase in SSTIs, there has been a concomitant rise in the incidence of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) [3]. A 20 days old male full term baby born to a G2P1D1 mother via lower segment cesarean section in view of non progression of labor with birth weight of 2.8 kgs presented in our hospital with subcutaneous abscess diffusly present on the left side of the scalp & face. Informant was father with good reliability. Patient presented with complaints of fever since 2 days and distension of abdomen since 2 days. Swelling over the scalp since birth. All relevant investigations sent & IV antiobiotics like meropenem & vancomycin started. Incision & drainage done by pediatric surgeon & 100 ml pus removed. IV antibiotics given for 14 days. Regular dressing done & patient discharged on day 16 of admission. The gold standard treatment for subcutaneous abscesses remains incision and drainage (I&D). The use of antibiotics for SSTIs after drainage is an area of great debate and variance. As a general guideline, the Infectious Disease Society of America (IDSA) recommends the use of antibiotics after I&D only in the presence of systemic signs of infection. In summary, abscesses are a very common presentation in the pediatric ED. MRSA is the most common isolate of these abscesses, regardless of risk factors. History and physical exam combined with ultrasound should be used to diagnose abscesses. As upper & lower limb skin abscess are more common, we here report facial abscess in neonate which was diffuse & successfully treated.
Cáncer de mama: factores de riesgo en mujeres
Authors: Alcocer Betty Sarabia , Gutiérrez Tomás Joel López , Rodriguez Pedro Gerbacio Canul , Canché Baldemar Aké , Caamal María Eugenia López , Chavez-Figueroa María Concepción Ruiz de , Gamboa Carmen Cecilia Lara , Canché Gonzalo Abdiel Canul
Published: July 2022

Objetivo: Determinar los factores de riesgo para el cáncer de mama en mujeres. Material y método: Estudio descriptivo, transversal y observacional. Resultados: De las 232 encuestadas el 55.2% no realiza autoexploración mamaria; el 44.8% ha usado anticonceptivos orales; el 32.8% es obesa; el 22.4% niega lactancia materna; el 13.8% no cuenta con antecedentes heredofamiliares; el 10.3% ha presentado enfermedad benigna en senos. Conclusiones: Los factores de riesgo más frecuentes fueron la falta de autoexploración mamaria, la obesidad y el uso de anticonceptivos orales.
Uso del blog como herramienta colaborativa en las prácticas externas en el grado en pedagogía
Authors: Ordóñez-Sierra Rosario , Rodríguez -Gallego Margarita R. , Segurado María Teresa Gómez del Castillo , Virué Rocío Piñero
Published: July 2022

La presente experiencia analiza la comparativa de expectativas y logros, de 15 estudiantes, que han cursado la asignatura Prácticas Externas I del Grado en Pedagogía en la Facultad de Ciencias de la Educación (Universidad de Sevilla) en centros educativos de Educación Primaria dependientes de la Delegación de Educación, así como instituciones, asociaciones y empresas de convenios con la Universidad de Sevilla. El principal objetivo ha sido reflexionar, intercambiar experiencias, supervisar, evaluar y mejorar el desarrollo de las Prácticas Externas a través del blog como herramienta colaborativa. El análisis de los comentarios ofrecidos en el blog corrobora el objetivo y un elevado nivel de logro de las expectativas que se planteaban los estudiantes ante el inicio de sus prácticas. Y, el 100% de los estudiantes participantes en el blog muestra satisfacción con su uso, recomendando su empleo al resto de docentes y para las prácticas de 4º curso.
Use of In Vitro Fertilisation Prediction Model in an Asian Population—Experience in Singapore
Authors: Saha Laxmi , Fook-Chong Stephanie MC , Rajesh Hemashree , Chia Diana SF , Yu Su Ling
Published: July 2022

Introduction: This retrospective study was conducted to perform an external validation of the in vitro fertilisation (IVF) predict model developed by Scott Nelson et al in an Asian population. Materials and Methods: All IVF cycles registered in the study centre from January 2005 to December 2010 were included. Observed and predicted values of at least 1 live birth per cycle were compared by discrimination, calibration. Hosmer-Lemeshow test was used to assess the goodness-of-fit of the model calibration and Brier score was used to assess overall model performance. Results: Among 634 IVF cycles, rate of at least 1 live birth was 30.6%. Causes of infertility were unexplained in 35.5% cases. Fifty-seven percent of women came for their first IVF treatment. First IVF cycle showed significantly higher success in comparison to subsequent cycles. The odds ratio of successful live birth was worse in women with endometriosis. Observed outcome was found to be more than the prediction of the model. The area under the curve (AUC) in this study was found to be 0.65 that was close to that of Nelson model (0.6335) done in internal validation. Brier score (average prediction error) of model was 0.2. Chi square goodness-of-fit test indicated that there was difference between the predicted and observed value (x2 =18.28, df = 8, P = 0.019). Overall statistical findings indicated that the accuracy of the prediction model fitted poorly with the study population. Conclusion: Ovarian reserve, treatment centre and racial effect on predictability cannot be excluded. So it is important to make a good prediction model by considering the additional factors before using the model widely.

Key words: Infertility, External validation, Live birth
A Biomechanical Study Comparing Cerclage Wiring Performed with a Power Tool versus the Manual Method
Authors: Koo Kevin , Zhou Zhihong , Yew Andy KS , Koh Joyce SB , Howe Tet Sen
Published: July 2022

Introduction: We conducted a biomechanical study comparing cerclage wiring using a power tool with the traditional manual method. Materials and Methods: Our study consisted of 4 experimental arms based on the method of fixation and diameter of wires. The 4 arms were: 1) power tool method using 0.8 mm cerclage wires, 2) power tool method using 1.0 mm cerclage wires, 3) conventional manual method using 0.8 mm cerclage wires, and 4) conventional manual method using 1.0 mm cerclage wires. Synthetic femur bones were employed in our study. Six specimens were prepared for each arm. Each specimen was cut lengthwise and pressure sensors were placed in between. For the power tool method, while maintaining tension, wires were coiled using the Colibri power tool until just before secondary coiling occurred. For the conventional manual method, each specimen was compressed by plier twisting for 10 rounds, while maintaining tension. Cerclaging and data recording was done thrice for each specimen, giving a total of 18 readings per arm. Peak and steady-state forces were recorded. Results: There was no significant difference between the peak forces recorded between the power drill and manual methods. The steady-state forces achieved using the power tool method were significantly higher than that achieved in the manual fixation method (0.8 mm wires: 54.89N vs 27.26N, P = 0.037; 1.0 mm wires: 71.59N vs 39.66N, P = 0.025). Conclusion: The power tool method achieved a superior steady-state force of compression across the fracture site for both 0.8 mm and 1 mm wires.

Key words: Conventional method, Peak force, Periprosthetic, Steady-state force
Long-term Outcomes of Medical Therapy Versus Coronary Revascularisation in Patients with Intermediate Stenoses Guided by Pressure Wire
Authors: Shi Hongyu , Lee Chi Hang , Chan Mark YY , Low Adrian F , Teo Swee Guan , Chan Koo Hui , Sethi Rishi , Richards Arthur Mark , Tan Huay Cheem
Published: July 2022

Introduction: This study aimed to examine the long-term clinical outcomes of coronary fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) in a real-world population in an Asian tertiary centre. Materials and Methods: All patients who underwent FFR measurement for intermediate coronary lesions in our centre from June 2002 to December 2009 were enrolled. A threshold of FFR ≤0.75 was used for revascularisation. All the patients were prospectively followed-up for major adverse cardiac events (MACE) of death, myocardial infarction (MI), target vessel revascularisation (TVR) and stent thrombosis. Results: Based on FFR measurement, 368 (57%) patients were treated medically while 278 (43%) underwent revascularisation. At a mean follow-up duration of 29.7 ± 16 months, 53 (14.4%) patients in the medical therapy group and 32 (11.5%) patients in the revascularised group experienced MACE (P = 0.282). There were no statistical differences in all the clinical endpoints between the 2 groups. Conclusion: Medical therapy based on FFR measurement is associated with low incidences of MACE at long-term follow-up.

Key words: Fractional flow reserve, Major adverse cardiac events, Percutaneous coronary intervention
Is the Apprehension Test Sufficient for the Diagnosis of Anterior Shoulder Instability in Young Patients without Magnetic Resonance Imaging (MRI)?
Authors: Kumar Krishna , Makandura Milindu , Leong Nicholas JJ , Gartner Louise , Lee Chin Hwee , Ng Dennis ZW , Tan Chyn Hong , Kumar V Prem
Published: July 2022

Introduction: The purpose of this study is to compare the sensitivities and positive predictive values (PPV) of the anterior apprehension test and magnetic resonance imaging (MRI) in the diagnosis of anterior labral tears in young patients with shoulder instability and to determine if surgery could be carried without this investigation in selected patients. Materials and Methods: We undertook a retrospective study of 168 patients aged between 15 and 30 years with a history of shoulder dislocation and compared the sensitivities and the PPV of the apprehension test with both MRI and magnetic resonance arthrograms (MRA) in the diagnosis of a Bankart lesion. The radiological investigations were interpreted by general practice radiologists and specialised musculoskeletal radiologists. All patients had their diagnosis confirmed by shoulder arthroscopy. Results: Our results showed that the apprehension test was highly reliable when it was positive with a PPV of 96%. It was more sensitive than MRI in the diagnosis of a Bankart lesion. The clinical test was significantly better when a musculoskeletal radiologist interpreted the MRI. The MRA interpreted by a musculoskeletal radiologist had the highest rates of sensitivity in detecting Bankart lesions. The figure was similar to that for the apprehension test. There was no difference in the PPVs among the clinical test, the MRI and the MRA read by the 2 categories of radiologists. Conclusion: We conclude that a routine MRI may be unnecessary in evaluating a young patient with clinically evident anterior shoulder instability if the apprehension test is positive. A MRA that can be interpreted by a musculoskeletal radiologist will be the next best investigation if the clinical test is negative or equivocal.

Key words: Dislocation, Glenohumeral joint, Radiological investigations
Genomics of Hereditary Colorectal Cancer: Lessons Learnt from 25 Years of the Singapore Polyposis Registry
Authors: Chew Min Hoe , Tan Wah Siew , Liu Yanqun , Cheah Peh Yean , Loi Carol TT , Tang Choong Leong
Published: July 2022

Introduction: The Singapore Polyposis Registry (SPR) was established in 1989 in Singapore General Hospital (SGH). The aims were to provide a central registry service to facilitate identification, surveillance and management of families and individuals at high risk of colorectal cancer. Materials and Methods: This is a review of published literature in the department. Results: The registry currently has 253 families with several genetic conditions—93 familial adenomatous polyposis (FAP) families, 138 Amsterdam-criteria positive presumed Lynch syndrome (LS) families, 12 families with Peutz Jeghers syndrome, 2 families with Cowden’s syndrome, and 8 families with hereditary mixed polyposis syndrome (HMPS). There are also 169 families with a strong family history of colorectal cancer but no abnormal genes yet identified. In FAP, a diagnostic tool developed has allowed a 94% local APC germline detection rate in FAP families. Knowledge obtained studying the phenotype of FAP patients has allowed better choice of surgery between ileal pouch anal anastomosis (IPAA) against an ileal-rectal anastomosis (IRA). In LS, our review has noted a highly heterogenous mutational spectrum and novel variants made up 46.7% (28/60) of all variants identified in this cohort. This may suggest that our Southeast Asian ethnic groups have distinct mutational variants from Western populations. Pathogenic mutations were only confined to MLH1 and MSH2, and identified in 28.8% of families. Conclusion: The impact of predictive gene testing for hereditary cancer risk in clinical practice has allowed evolution of care. Risk-reducing surgery and aggressive surveillance allows reduction in morbidity and mortality of patients. The SPR will continue to grow and improve outcomes in hereditary colorectal cancer patients and families. Key words: Familial adenomatous polyposis, Genetic testing, Lynch syndrome
Health Screening Behaviour among Singaporeans
Authors: Wong Hui Zhen , Lim Wei-Yen , Ma Stefan SL , Chua Lily AV , Heng Derrick MK
Published: July 2022

Introduction: This study assessed the health screening behaviour of Singaporeans and evaluated factors associated with low uptake of screening tests. Materials and Methods: Data from the 2010 National Health Survey, which was conducted on Singapore citizens and permanent residents, was used in this analysis. Multivariate Cox regression was used to evaluate the relationship between sociodemographics and health screening behaviour for selected chronic diseases (hypertension, diabetes and hypercholesterolaemia) and cancers (cervical, breast and colorectal). National recommendations for age at which screening should be initiated and appropriate screening interval were used to defi ne appropriate screening behaviour. Results: More respondents have had their last chronic disease screening done within the recommended time period compared to cancer screening. A total of 77.8%, 63.4% and 54.9% of the respondents had their last hypertension, diabetes and hypercholesterolaemia done within the recommended time period respectively, while less than 50% of the respondents had their cervical (45.8%), breast (32.9%) and colorectal (20.2%) cancer screenings done within the recommended time period. Respondents with higher household income or more years of education were more likely to have undergone screening within the recommended time period. Indians, who are at higher risk of chronic diseases such as diabetes and hypercholesterolaemia, were also more likely to have been screened. A total of 69.9% and 79.5% of the respondents with previously undiagnosed diabetes and hypertension had reported to have done diabetes and hypertension screenings respectively, within the recommended time period. Conclusion: Sociodemographic factors that could be associated with a lower uptake of screening tests include: 1) low household income, 2) low education level, and 3) Malay ethnicity. Health promotion programmes and outreach to these groups can be enhanced to further improve screening uptake. Key words: Diabetes screening, Hypercholesterolaemia screening, Hypertension screening
Hyperfamiliarity in Dementia and Mild Cognitive Impairment
Authors: Kwok Kathryna SH , Hameed Shahul , Tay Sze Yan , Koay Way Inn , Koh Sharon , Gabriel Christopher , Doshi Kinjal , Fook-Chong Stephanie M , Ting Simon KS
Published: July 2022

Introduction: Hyperfamiliarity, a phenomenon in which feelings of familiarity are evoked by novel stimuli, is well described in epilepsy and the lesioned brain. Abnormality of familiarity in Alzheimer’s disease (AD) and mild cognitive impairment (MCI) have also been described in the literature, but more from a neuropsychological approach perspective. Currently, there is a lack of study on the real-life experience of familiarity abnormality in dementia and MCI. Our aim was to compare the occurrence of hyperfamiliarity among dementia and MCI. Materials and Methods: We recruited 73 participants, 29 with AD, 10 with vascular dementia, 7 with MCI and 27 healthy controls, and administered a questionnaire to assess hyperfamiliarity frequency. Results: Hyperfamiliarity was observed in real-life in cognitive impairment, but was unrelated to its severity or underlying aetiology. Conclusion: This study highlights the similar rate of occurrence of hyperfamiliarity in the daily life of individuals with cognitive impairment. Future research should examine neuropsychological correlations and mechanisms that contribute to such observations. Key words: Alzheimer’s disease, Delusional misidentification syndrome, Vascular dementia
Proposed Marketing Initiative to Increase Brand Awareness and Purchase Conversion Case Study Brand: Ajoy Biscuit Stick
Authors:   School of Business and Management, Institut Teknologi Bandung, Rachmawati Ellyza
Published: July 2022

One of the brand portfolios that is expected to grow to support Claygo’s commercial expansion in Indonesia especially in the biscuit category is Ajoy. According to the 2020–2021 results, Ajoy is dealing with significant business issues, such as unmet sales targets that are negatively related to category growth. Ajoy’s penetration rate is likewise still very low, at less than 1%, with a trialist base of just 0.6 to 0.8 percent. This study uses a quantitative approach with the type of descriptive research. The approach to obtain the data is done with the survey by utilizing online questionnaires. Ajoy brand awareness is relatively poor, primarily due to the advertisement’s low share of voice. Low purchase conversion results from low awareness, which is also a result of a number of barriers, including product knowledge, price, and physical and mental availability. Due to Ajoy’s higher pricing but unable to establish a solid judgment regarding the price point, the premium positioning it seeks to establish is not well received by the target market. This study will help Ajoy to identify its low brand awareness trigger and low purchase conversion (from aware to ever purchase metric) trigger, as well as develop the brand message corresponding to Ajoy’s premium positioning and define the integrated marketing communication initiatives to deliver the brand message to Ajoy’s prime prospect.
Social Media Affects Emotional and Cognitive Status
Authors:   Siriwat Wittaya Cambridge Program, Permsen Road, Sai Mai, Bangkok, Thailand 10220, Chaeycharoen Sathirachat
Published: July 2022

Social media has played a significant role in people’s lives and can be helpful to them in a variety of ways. However, if misused, social media can also be problematic. Social media impacts how kids establish their identities because it gives them access to a platform that may also cause them to feel anxious, insecure, and depressed since they work so hard to maintain their online reputations. Allowing young people to use social media can lead to issues such as cyberbullying, sexting and Facebook suffering. Teenagers may turn to drugs and alcohol as a coping mechanism if they are unsure how to handle the problems. Teenagers can experience benefits and risks from using the internet, so physician services must cooperate with adolescents and their families to support the benefits that young people get from using social media while also assisting them in developing preventative and coping mechanisms to deal with any potential risks.
Extradition Law in Indonesia And its Urgency in Fighting International Crime
Authors:   Universitas Muhammadiyah Ponorogo
Published: July 2022

The legal instrument for extradition has been regulated in the Republic of Indonesia Law no. 1 of 1979 in general, extradition is a result of asylum rights, namely the right to obtain political asylum, but at this time extradition is used to penetrate state boundaries in the sense of applying national criminal law for criminals who flee the country abroad, and to To create a civilized international civil society that upholds the truth, it is necessary to implement the law which is a manifestation of justice and truth itself.