bluuebunny/crossref_metadata_2025 huggingface dataset:
Rational Design of Biological Crystals with Enhanced Physical Properties by Hydrogen Bonding Interactions
Authors: Yuan Hui , Xue Bin , Yang Dingyi , Rencus-Lazar Sigal , Cao Yi , Gazit Ehud , Tan Dan , Yang Rusen
Published: January 2023

Hydrogen bonds are non-covalent interactions and essential for assembling supermolecules into ordered structures in biological systems, endowing crystals with fascinating physical properties, and inspiring the construction of eco-friendly electromechanical devices. However, the interplay between hydrogen bonding and the physical properties is not fully understood at the molecular level. Herein, we demonstrate that the physical property of biological crystals with double-layer structures could be enhanced by rationally controlling hydrogen bonding interactions between amino and carboxyl groups. Different hydrogen bonding interactions result in various thermal, mechanical, electronic, and piezoelectric properties. In particular, the weak interaction between O and H atoms contributes to low mechanical strength that permits important ion displacement under stress, giving rise to a strong piezoelectric response. This study not only reveals the correlation between the hydrogen bonding and physical properties in double-layer structures of biological crystals but also demonstrates the potential of these crystals as functional biomaterials for high-performance energy-harvesting devices. Theoretical calculations and experimental verifications in this work provide new insights into the rational design of biomaterials with desirable physical properties for bioelectrical devices by modulating intermolecular interactions.
Metal–Phenolic Network-Facilitated “Foe-to-Friend” Conversion of Melittin for Cancer Immunotherapy with Boosted Abscopal Effect
Authors: Guo Yuxin , Zhang Xinping , Wang Shao-Zhe , Feng Hui-Heng , Wu Shun-Yu , Wu Fu-Gen
Published: January 2023

As a naturally occurring cytolytic peptide, melittin (Mel) has strong cytolytic activity and is a potent therapeutic peptide for cancer therapy. However, the serious hemolytic activity of Mel largely impedes its clinical applications. In this work, based on the strong interactions between proteins/peptides and polyphenols, we develop a tannic acid–Fe
3+
metal–phenolic network (MPN)-based strategy that can convert Mel from foe to friend via shielding its positive charges and reducing its hemolytic activity. Besides, an immune adjuvant resiquimod (R848) is also introduced for immunostimulation, affording the final Mel- and R848-coloaded nanodrug. The Mel-caused membrane disruption can induce immunogenic cell death for immunostimulation, R848 can act as an immune adjuvant to further facilitate the immunostimulatory effect, and the tannic acid–Fe
3+
MPN-mediated Fenton reaction can produce reactive oxygen species for cancer treatment. Further experiments reveal that the nanodrug can effectively cause immunogenic cell death of tumor cells and arouse robust intratumoral and systemic antitumor immunostimulation. In the bilateral tumor-bearing mouse models, the nanodrug considerably destroys the primary tumor and also boosts the abscopal effect to ablate the distant tumor. Collectively, the MPN-facilitated “foe-to-friend” strategy may promote the practical applications of Mel and foster the development of cancer immunotherapeutics.
Microtubule Assists Actomyosin to Regulate Cell Nuclear Mechanics and Chromatin Accessibility
Authors: Geng Jiwen , Kang Zhefeng , Sun Qian , Zhang Man , Wang Peng , Li Yupei , Li Jiameng , Su Baihai , Wei Qiang
Published: January 2023

Cellular behaviors and functions can be regulated by mechanical cues from microenvironments, which are transmitted to nucleus through the physical connections of cytoskeletons in the cells. How these physical connections determine transcriptional activity were not clearly known. The actomyosin, which generates intracellular traction force, has been recognized to control the nuclear morphology. Here, we have revealed that microtubule, the stiffest cytoskeleton, is also involved in the process of nuclear morphology alteration. The microtubule negatively regulates the actomyosin-induced nuclear invaginations but not the nuclear wrinkles. Moreover, these nuclear shape changes are proven to mediate the chromatin remodeling, which essentially mediates cell gene expression and phenotype determination. The actomyosin disruption leads to the loss of chromatin accessibility, which can be partly recovered by microtubule interference through nuclear shape control. This finding answers the question of how mechanical cues regulate chromatin accessibility and cell behaviors. It also provides new insights into cell mechanotransduction and nuclear mechanics.
PEMODELAN STRUKTURAL EQUATION MODEL- PARTIAL LEAST SQUARE (SEM-PLS) PADA MINAT BERTRANSAKSI MENGGUNAKAN APLIKASI OVO
Authors: Ningsih Setia , Dukalang Hendra , Arsal Armayani
Published: January 2023

The payment system in Indonesia is transforming from making payments in cash to non-cash. Non-cash payments can be made with various payment applications, one of which is the OVO application. Non-cash payments are less loved by many people, this is due to concerns about the security or ease and effectiveness of non-cash payment applications. Therefore, this study was conducted to analyze the factors that influence student interest in Gorontalo province in transacting using the OVO application using the Structural Equation Model Partial Least Square (SEM-PLS). The data analysis technique used is variance-based SEM. The results showed that the perceived convenience, effectiveness and security variables affected the interest in transacting using the OVO application with an R-square value of 70.70 percent.
BİR TEKSTİL FABRİKASINDA PSİKOSOSYAL RİSKLER VE MENTAL SAĞLIK DURUMU
Authors: Arkan Demiral Gökçen , Şahan Ceyda , Aydin Ozgur Esra , Vatansever Mustafa , Demiral Yucel
Published: January 2023

Bu kesitsel çalışmada tekstil sektöründe bir iş yerinde psikososyal riskler ve mental sağlık birlikteliğinin
değerlendirilmesi amaçlanmıştır. 407 çalışana psikososyal risk değerlendirme ölçeği uygulanmıştır. Çalışmanın bağımlı
değişkeni mental sağlık durumu, Genel Sağlık Anketi’nin (GSA) 12 soruluk formu ile değerlendirilmiştir. Temel bağımsız
değişkenler, KOPSOR-TR-kısa ile değerlendirilen psikososyal riskler, yaş, cinsiyet, medeni durum, öğrenim düzeyi,
mesleki sınıf, kronik hastalık öyküsü, mevcut iş yerinde çalışma süresi, vardiyalı çalışma durumu, günlük çalışma saati,
gece çalışma durumu, yöneticilik görevi varlığı, iş kazası geçirme durumudur. İstatistik analizlerde tanımlayıcı
istatistikler sayı ve yüzde olarak, dağılım istatistikleri ise ortalama ve standart hata olarak belirtilmiştir. İki gruplu sürekli
değişkenlerin karşılaştırılmasında bağımsız gruplarda t testi kullanmıştır. Kategorik değişkenlerin karşılaştırılmasında ki
kare testi yapılmıştır. Çok değişkenli analizlerde lojistik regresyon modelleri kullanılmıştır. Bu çalışmada psikososyal
riskler içerisinde sırasıyla en çok çalışma hızının yüksek olması, tanınırlık eksikliği, işe etki eksikliği, sosyal destek
eksikliği öncelikli riskler olarak saptanmıştır. Kadınların psikososyal risk puanları erkeklerden daha yüksektir. Mesleksel
sınıfa göre değerlendirildiğinde psikososyal risklerin çoğu beyaz yakalılarda mavi yakalılara göre anlamlı olarak yüksek
bulunmuştur. Mental sağlık beyaz yakalıların %76’sında kötü saptanırken; mavi yakalılarda bu oran %84’tür ve bu fark
anlamlıdır (p<0.05). Beyaz yakalılarda yaş ve cinsiyete göre düzeltildiğinde psikososyal risklerin çoğunun mental sağlık
üzerine olumsuz etkileri olduğu saptanmıştır. Bu bulguya ek olarak tekstil sektöründe çalışan beyaz yakalıların da
literatürde bildirilen mavi yakalılar kadar psikososyal risklerden etkilenme riskleri olabileceği düşünülmüştür.
Anahtar kelimeler: KOPSOR, psikososyal, tekstil, mental sağlık, GSA.
RESEARCHING OF RISK FACTORS FOR SEVERE CARPAL TUNNEL SYNDROME - IS HOUSEWIFERY A RISK?
Authors: Balduz Metin , Nazlıcan Ersin , Mete Burak , Balduz Bahar , Akbaba Muhsin
Published: January 2023

Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy. In this study, risk factors of severe CTS were examined.
This study was conducted on 227 patients diagnosed with CTS in EMG laboratuary. The criteria of American Academy of
Electrodiagnostic Medicine was used as the diagnosis for CTS. All patients were examined for bilateral median and ulnar motor and
sensory peak latency, amplitude and conduction velocities. The patients were classified into 4 groups electrophysiologically; Normal,
Light, Medium, Severe. Electrophysiological classification was compared with the identified risk factors. The mean age of the patients
was 51.04±13.37 (min=18-max=83). Severe CTS cases in both hands were higher in housewives. Housewifery increased the risk of
severe CTS in the right and left hand by 2.74 and 2.23 times, respectively. In addition, obesity increased the risk of severe CTS in the
right and left hand by 5.10-4.40, presence of lateral epicondylitis was 2.73-4.19 and medial epicondylitis was 4.39-4.93, respectively.
Hand dominancy was increased the risk of severe CTS by 6.88 times for the left hand and 1.15 times for the right hand. Otherwise in
multivariate analyse of left hand results, obesity increase the risk of severe CTS by 3.34, left hand dominancy 7.83 times, chronic
disease 2.62 times, and for the right hand being a housewife increases the risk by 2.14, obesity 4.68 times and medial epicondylitis
6.40 times. This study put forth that being a housewife, obesity, dominant hand, presence of lateral or medial epicondylitis are the risk
factors of severe CTS.
EVALUATION OF THE RELATIONSHIP BETWEEN SICK BUILDING SYNDROME PREVALENCE AND INDOOR AIR QUALITY IN SCHOOLS
Authors: Tekin Ömer Faruk , Arıkan İnci
Published: January 2023

In this study, it was aimed to evaluate the relationship between Sick Building Syndrome (SBS) prevalence and indoor
air quality in primary and middle schools in rural and urban areas in the west of Turkey. This cross-sectional study was
carried out between September and November 2018 in three randomly selected schools in rural and urban areas. The
questionnaire designed to reveal perceived indoor air quality and SBS was completed by the parents of the students.
On determined days, particulate matter (PM) and carbon dioxide (CO2) levels were measured in the classrooms.
Multiple logistic regression model was developed to investigate the relationship between SBS and some variables. The
study was conducted on 966 students. The prevalence of SBS was found to be 10.2%. The most common SBS
symptoms were listed as fatigue, nasal congestion-discharge, cough, and headache, respectively. The measured PM2.5,
PM10, and CO2 values were higher in the urban area than in the rural area. The risk of SBS was found to be higher in
primary school students, in students who have poor perceived classroom air, lighting, and noise quality, and in students
studying in classrooms with higher PM2.5, PM10, and CO2 values. One in ten students had SBS. There was a relationship
between SBS and poor perceived indoor air quality and increased CO2 and PM values. Raising awareness about SBS
and conducting studies aimed at improving related factors in schools are thought to be important.
Penerapan Model Pembelajaran Kooperatif Tipe Jigsaw Terhadap Aktivitas belajar Santri
Authors: Supriyadi Agus , Anam Khairul
Published: January 2023

Pendidikan yang semakin berkembang dan maju, Pondok Pesantren merupakan lembaga pendidikan keagamaan dituntut untuk semakin mengembangkan aspek-aspek yang dapat menunjang pendidikan dan pembelajaran semakin baik Kegiatan pembelajaran kajian kitab kuning atau kitab klasik merupakan kegiatan yang wajib di kebanyakan pondok pesantren, termasuk juga di asrana Darul Kutub I’dadiyah Asrama Ma’hadul Qur’an Pondok Pesantren Salafiyah Syafi’iyah sukorejo. Metode penelitian dengan mengngunakan pendekatan penelitian kualitatif dan menghasilkan kesimpulan sebagai berikut : 1) Mengarahkan peserta didik untuk menyimak dan membaca informasi terkait materi, membentuk peserta didik menjadi beberapa kelompok, meminta satu orang dari masing-masing kelompok ahli. Dan kelompok ahli kembali ke kelompoknya masing-masing untuk memaparkan hasil diskusi mereka dan langkah terakhir masing-masing kelompok membuat kesimpulan dalam bentuk mapping terkait hasil diskusi kelompok mereka.2) faktor-faktor pendukung pertama penguasaan guru terhadap model Pembelajaran kooperatif Tipe Jigsaw. Kedua guru memahami kemampuan dan karakteristik para peserta didik di dalam kelas
Análisis del valor agregado en la formación profesional: un caso de estudio en Unibagué
Authors: Ramírez Olmos Diego , Rojas Penagos Juan , Bermeo-Andrade Helga Patricia
Published: January 2023

Determinar cuál es el valor agregado que proporciona la formación universitaria a un estudiante durante el proceso de enseñanza-aprendizaje que termina en su profesionalización es una de las preocupaciones de todos aquellos programas académicos universitarios, que buscan ser acreditados de alta calidad. Este reporte presenta el análisis del programa de Ingeniería Industrial en la Universidad de Ibagué, tomando como base los resultados generados en los estudiantes egresados durante el periodo 2016-2019. Los hallazgos sugieren que el Programa en buena medida logra generar valor agregado en sus estudiantes, en el desarrollo de competencias genéricas propias de un profesional, como en las competencias específicas propias de un ingeniero industrial.
Competencias parentales para facilitar el desarrollo de funciones ejecutivas en la niñez temprana
Authors: Hurtado Segura Melany , Fierro Cedeño María Paula , Duque Romero Claudia Alejandra , Puerta Cortés Diana Ximena , Cupajita-Rodríguez Laura
Published: January 2023

Se expone una breve reflexión sobre el desarrollo de las funciones ejecutivas en la niñez temprana y su relación fundamental con las competencias parentales. Lo anterior se desarrolla a partir de una revisión a la luz de teorías ecológicas y del apego. También se presentan algunos avances actuales sobre el tema. Se concluye que es necesario continuar generando esfuerzos desde la investigación para fortalecer los procesos de atención a la infancia a través de la focalización de intervenciones dirigidas a los adultos que están a cargo del cuidado de los niños, a fin de lograr la sostenibilidad social y reducir los índices de pobreza en la sociedad.
ECOLOGICAL DUE DILIGENCE - MAINSTREAM IN INSURANCE
Authors: Korol Svitlana
Published: January 2023

Introduction. In today's world, environmental problems related to accidents, natural disasters and catastrophes have been exacerbated by environmental pollution caused by the ongoing russian-Ukrainian war, which continues to this day. At the state level, in this situation, of course, it is difficult to use instruments of influence, as in Ukraine there is no legal framework that would serve as a foundation for legislative regulation of environmental insurance. Given this positioning in this context, environmental insurance becomes especially relevant, which is preceded by environmental due diligence - the mainstream of the world.
Purpose. Identify the importance of environmental due diligence for the world community and prove that it is mainstream in insurance in today's world.
Method (methodology). The research used such methods as logical, which allowed to analyze scientific works in the field of environmental due diligence; analysis and synthesis, which made it possible to identify factors influencing the mainstream in insurance; graphical, which allowed to interpret the results in a visual form.
Results. The stages of development of climate policy in the world are determined. Emphasis is placed on decarbonisation, which includes such areas as resources (renewable energy sources, restrictions on mining, abandonment of coal generation, capture, use and storage of carbon dioxide, hydrogen energy), infrastructure (implementation and application of «green» tools), markets and carbon pricing (CO2 tax (carbon tax, transboundary carbon tax), greenhouse gas emission allowance trading system, and a combination of these approaches; carbon reporting), consumers (abandonment of internal combustion engines, limitation of emissions in the air transport sector) emission control in the maritime transport sector), investments (attraction of investment funds in "green" technologies). Direct and indirect impacts on the environment due to active hostilities are characterized. Recommendations for «green» reconstruction of the affected regions of Ukraine due to the full-scale invasion of russia are given.
The Role of Local Communities in the Discourse of Controversial Heritage of Norway and Estonia
Authors: Paulus Ave , Brekke Arnstein Bard
Published: January 2023

The current paper analyses the paradigm shifts in the discourse of heritage sites with tragic personal stories, memories, and remains, emphasising local communities' role in reframing controversial heritage in Norway and Estonia. Although these stories are from different cultures and places, they all spin around the same - how do we deal with the most delicate strings in the human mind, beliefs, sorrows, and dignity. The sites under discussion are "ghosts" of the tragedies of the past century. Among heritage communities, states and experts, there were intense debates about the values and fate of those areas. Besides several historical, political and socioeconomic issues, personal wounds were reconciled. The first case describes the heritage communities' initiatives in accessing and reconciling values of contested Cold War heritage  - Suurpea Naval Base erected during Soviet Occupation and deportations on the coasts of Estonia. The second case deals with the initial demolition and later recognition of Sami burial sites and sacred landscapes of Arctic Norway, re-gaining the rights to Saami heritage and restitution. These cases highlight the importance of inclusiveness while dealing with conflicting histories, reconciliation, restitution, and dignity of heritage and communities concerned. Authors rely on a holistic concept of cultural heritage. Cultural communities, spirit and feeling of their presence are essential indicators of character and sense of place. The authors show the benefits of a people-centred approach towards heritage as the basis of transformative change in heritage protection. The authors` positions are not purely academic – they have been involved in defining and protecting the cultural heritage of the areas under discussion.

Keywords: cultural heritage, heritage communities, sociocultural accessibility, inclusiveness, restitution, reconciliation
Fabrication of thin ferroelectric Hf0.5Zr0.5O2 films by millisecond flash lamp annealing
Authors: Tanimura Hideaki , Ota Yuto , Kawarazaki Hikaru , Kato Shinichi , Nara Yasuo
Published: January 2023

We used millisecond flash lamp annealing (FLA) to form thin ferroelectric Hf0.5Zr0.5O2 (HZO) films with thicknesses of less than 10 nm and with remanent polarization up to 30 μC cm−2. A clear dependency of the polarization on the annealing temperature and time was observed, indicating that the precise management of the thermal budget is a key factor in forming ferroelectric HZO. We also show and compare the process windows within which ferroelectricity in 10 and 5 nm samples is obtained. The results show that a high thermal budget is necessary for thinner samples. We examined the endurance characteristics and a greater endurance compared to rapid thermal annealing treatment was observed with more than 1010 cycles without breakdown confirmed in 5 nm thick samples. The data indicates that there is the possibility of further thickness scaling whilst retaining highly durable characteristics for films annealed by FLA.
High sensitive vector measurement of nonlinear harmonic responses in surface acoustic wave/bulk acoustic wave radio frequency devices
Authors: Himata Seiya , Omori Tatsuya
Published: January 2023

This paper proposes a high-sensitive measuring method for nonlinear harmonic responses in radio frequency (RF) SAW/BAW devices using a lock-in amplifier. The proposed system could detect the nonlinear complex harmonic responses generated in an RF SAW resonator, even if the responses are weaker than −140 dBm. The detection limit is extended by around 10 dB compared with the conventional technique using a cross-domain analyzer.
Development of a real-time temperature measurement technique for SiC wafer during ultra-rapid thermal annealing based on optical-interference contactless thermometry (OICT)
Authors: Yu Jiawen , Hanafusa Hiroaki , Higashi Seiichiro
Published: January 2023

A real-time temperature measurement technique with high spatial (≤20 μm) and temporal (≤1 μs) resolutions for SiC wafers during ultra-rapid thermal annealing (URTA) has been developed based on optical-interference contactless thermometry (OICT). This technique consists of hardware (OICT imaging setup) and software (fast temperature extraction program). Under URTA by atmospheric-pressure thermal plasma jet, a clear variation of optical-interference fringes was observed by a high-speed camera and then analyzed by a fast temperature extraction program using image preprocessing and a database. 3.5D (x, y, z and time) temperature distribution in SiC wafer was obtained within 0.43 s.
Submicron structures created on Ni thin film by submicron focusing of femtosecond EUV light pulses
Authors: Motoyama Hiroto , Iwasaki Atsushi , Mimura Hidekazu , Yamanouchi Kaoru
Published: January 2023

Using a newly developed submicron focusing system equipped with a large-aperture Wolter mirror with a precisely figured surface, we irradiate a Ni thin film coated on a silicon substrate with femtosecond extreme ultraviolet (EUV) laser pulses, generated as high-order harmonics of near-infrared femtosecond laser pulses. At the fluence of up to 100 mJ cm−2 at the sample surface, we show that the surface morphology can be modified with a submicron spatial resolution and that a protruding structure is formed when the fluence is 60–70 mJ cm−2, exhibiting a characteristic feature of the femtosecond EUV light processing of a thin metal surface.
Graphene assembled film based conformal sensor array for submillimeter crack location and direction detection
Authors: Guan Huijuan , Song Rongguo , Tong Cong , Zhao Xin , Yang Yingping , He Daping
Published: January 2023

In this paper, a conformal CSRR derived sensor array with two resonant frequencies based on a graphene assembled film (GAF) is proposed to detect and determine the direction of submillimeter cracks on aluminum plates. The GAF sensor array consists of a microstrip line, a dielectric substrate and a reference ground with two CSRR derived resonant structures. The GAF sensor array has a high sensitivity of 270 MHz for the curved aluminum plate with a crack width of 0.2 mm. In addition, the CSRR derived resonant structure array of the GAF sensor effectively detects the direction of the crack.
Fast dual-comb spectroscopy based on a dual-wavelength all-fiber ring laser with high repetition rate
Authors: Li Yan , Zhang Jin , Wu Feng , Liu Guanghui , Xiao Xiaosheng
Published: January 2023

We demonstrate fast dual-comb spectroscopy based on a high-repetition-rate dual-wavelength erbium-doped fiber laser with a large repetition rate difference. It can operate in three different dual-wavelength states with repetition rate differences of 4.32, 2.74 and 3.635 kHz, respectively. To the best of our knowledge, the corresponding refresh time can be as low as 231 μs, which is the fastest in dual-comb spectroscopy using a single fundamentally mode-locked all-fiber laser. The high repetition rate of approximately 154.68 MHz provides a maximum optical frequency bandwidth of 4.37 THz. Dual-comb spectroscopy was used to measure the transmittance curve of the Fabry–Perot etalon.
FORMAT DAN KELENGKAPAN PENGISIAN SERTIFIKAT MEDIS PENYEBAB
KEMATIAN DI RUMAH SAKIT TK. II 03.05.01 DUSTIRA KOTA CIMAHI
TAHUN 2020
Authors: Rusman Andri Andrian , Triningtyas Anastasia Yani , Mahendra Muhamad Debry
Published: January 2023

Sertifikat Medis Penyebab Kematian (SMPK) adalah surat yang dibuat dan diterbitkan oleh
rumah sakit berdasarkan standar WHO dan diisi oleh dokter penanggung jawab untuk
menerangkan bahwa seseorang telah meninggal. Kelengkapan poin format sangat penting
karena sangat memengaruhi kualitas dari Sertifikat Medis Penyebab Kematian (SMPK). Di
Indonesia referensi pedoman penulisan SMPK telah diterbitkan oleh Kementrian Kesehatan
melalui Badan Penelitian dan Pengembangan Kesehatan. Pada penelitian ini peneliti
menggunakan panduan dari Kemenkes sebagai acuan. Tujuan penelitian adalah untuk
mengetahui kelengkapan poin format dan kelengkapan pengisian sertifikat medis penyebab
kematian. Penelitian dilakukan di Rumah Sakit Tk. II 03.05.01 Dustira Kota Cimahi. Objek
yang diteliti pada penelitian ini adalah sertifikat medis penyebab kematian. Penelitian ini adalah
penelitian deskriptif dengan pendekatan potong lintang menggunakan teknik purposive
sampling dan kelengkapan poin format dinilai menggunakan checklist box. Hasil penelitian dari
91 SMPK didapatkan kelengkapan poin format SMPK RS Tk. II 03.05.01 Dustira dengan
format Kemenkes yaitu 9 dari 13 poin atau 4 poin tidak lengkap yaitu tempat dan tanggal lahir,
maternal atau tidak bagi wanita usia subur, cara pemulasaran, dan penyebab kematian.
Kelengkapan pengisian formulir SMPK didapatkan hasil 100% yaitu semua formulir SMPK
terisi lengkap. Kelengkapan pengisian sudah baik, namun formatnya belum sesuai Kemenkes
karena merujuk pada kebijakan Pusat Kesehatan Angkatan Darat (PUSKESAD). Meskipun
tidak lengkap, penyebab kematian dapat dilihat pada dokumen resume medis RS Tk. II 03.05.01 Dustira. Pusat Kesehatan Angkatan Darat perlu melakukan evaluasi format SMPK
demi lengkapnya informasi kematian.
PENDERITA DIABETES MELITUS DI KECAMATAN MAMAJANG
KOTA MAKASSAR
Authors: Anita Anita , Ahmad Ahyar , Natsir Hasnah , Rianto Muh.Rifo , Sarean Hasnah , Karim Harningsih , Bano Nur Hidayah
Published: January 2023

Diabetes Melitus merupakan kelompok penyakit metabolik dengan karakteristik hiperglikemia
akibat kelainan sekresi insulin. Tingginya kadar glukosa pada kulit dapat berkontribusi terhadap
manifestasi kulit sehingga rentan terinfeksi jamur, di antaranya jamur dermatofita. Dermatofita
ini merupakan golongan jamur yang melekat dan tumbuh pada jaringan keratin seperti kulit dan
kuku, sebagai sumber nutrisi untuk membentuk kolonisasi. Tujuan penelitian ini untuk
mengidentifikasi jamur dermatofita serta mengetahui morfologi dermatofita pada kuku dan
kulit sela jari kaki penderita diabetes melitus di Kecamatan Mamajang, Kota Makassar. Subjek
pada penelitian ini adalah 15 orang penderita diabetes melitus, dengan sampel berupa kerok
kuku dan kulit sela jari kaki. Hasil penelitian yang dilakukan pemeriksaan makroskopik dan
mikroskopik, ditemukan dua sampel yang jamur dermatofita yaitu Trichophyton rubrum dan
Microsporum gypseum, sedangkan sampel lainnya ditemukan jamur non dermatofita, antara
lain Candida albicans, Mucor michelli, Aspergillus fumigatus, Aspergillus flavus, dan
Aspergillus niger. Kesimpulan penelitian ini adalah ditemukan dua jamur dermatofita spesies
Trichophyton rubrum dan Microsporum gypseum pada kuku dan kulit sela jari kaki penderita
diabetes melitus di Kecamatan Mamajang, Kota Makassar.
EFEK EKSTRAK ETANOL KULIT BUAH NAGA MERAH TERHADAP
FAGOSITOSIS BAKTERI OLEH MONOSIT
Authors: Ramdhan Muhammad Raihan , Sriyanti Nurjanah , Putri Sri Betha , Cahyani Fauzia Rahma , Herawati Iis , Aryanto Eko Fuji
Published: January 2023

Prevalensi penyakit infeksi di Indonesia masih tinggi, di antaranya Infeksi Saluran Pernapasan
Atas (ISPA) 9,3% dan diare 8%. Penyakit infeksi menjadi penyebab kematian kedua tertinggi
pada kelompok usia > 55 tahun setelah penyakit pada sistem peredaran darah. Buah naga merah
(Hylocereus lemairei (Hook.) Britton & Rose) memiliki manfaat bagi kesehatan, namun saat
ini kulit buah naga merah belum dimanfaatkan. Ekstrak etanol kulit buah naga juga telah
diketahui berpotensi sebagai antioksidan yang tinggi. Penelitian ini bertujuan untuk mengetahui
efek ekstrak kulit buah naga merah terhadap fagositosis bakteri oleh monosit. Penelitian
dilakukan dengan tahapan: pembuatan ekstrak etanol kulit buah naga merah, pengambilan
sampel darah manusia dan isolasi peripheral blood mononuclear cells (PBMC) dan monosit,
pemberian ekstrak etanol kulit buah naga merah ke dalam sumuran monosit, pengujian bakteri
uji menggunakan Staphylococcus aureus ATCC 29213 dan Escherichia coli ATCC 25922,
pengambilan dan pengkulturan bakteri uji, dan penghitungan jumlah koloni bakteri yang
tumbuh. Hasil penelitian menunjukkan bahwa pemberian ekstrak kulit buah naga merah dengan
konsentrasi 10 μg/ml menghasilkan efek yang paling besar dalam meningkatkan jumlah S.
aureus yang difagositosis, yaitu sebesar 4,31% dan ekstrak dengan konsentrasi 5 μg/ml
meningkatkan jumlah E. coli yang difagositosis sebesar 1,26%. Analisis statistik tidak
menunjukkan perbedaan yang bermakna antargrup (p > 0,05). Penelitian ini menunjukkan bahwa pemberian ekstrak etanol kulit buah naga merah tidak memberikan efek yang bermakna
terhadap fagositosis bakteri oleh monosit.
MUTASI GENETIK PADA KASUS GAGAP: STUDI PUSTAKA
Authors: Bagus Suastika Komang Ari , Wulandari Retno Dwi
Published: January 2023

Gagap (stuttering) adalah suatu gangguan dalam berbicara yang ditandai dengan terjadinya
pengulangan atau perpanjangan dan penghentian bunyi atau suku kata. Gagap dapat diderita
oleh segala usia, terutama pada usia anak-anak (developmental stuttering) yang dapat
menyebabkan gangguan kefasihan dan keterlambatan dalam hal berbicara. Insiden seseorang
pernah mengalami gagap dalam hidupnya adalah sekitar 5% populasi dunia atau sekitar 60
juta orang. Studi menunjukkan terdapat beberapa gen yang berkaitan dengan terjadinya gagap.
Mutasi pada gen tersebut merupakan faktor risiko gagap di kemudian hari. Studi Pustaka ini
akan membahas mutasi genetik pada gagap dalam 4 bagian,yaitu (a) klasifikasi, (b)
prevalensi, (c) patofisiologi, dan (d) etiologi. Sebagai kesimpulan, pada penderita gagap, gen
yang mengalami mutasi, yaitu gen GNPTAB (kromosom 12q), GNPTG (kromosom 16p13.3),
NAGPA (kromosom 16p.13.3), AP4E1 (kromosom 15q21.2), gen SLC6A3 (kromosom
5p15.3), dan DRD2 (kromosom 15q23), gen CYP17 dan CYP19 (kromosom 10q). Dari mutasi
pada gen tersebut, yang paling sering ditemukan adalah mutasi pada gen GNPTAB, GNPTG,
dan NAGPA. Perbedaan mutasi yang ditemukan dipengaruhi oleh perbedaan populasi dan
besar sampel yang diteliti. Selain faktor genetik, terdapat faktor nongenetik sebagai faktor
risiko gagap. Diperlukan penelitian untuk mengetahui mutasi gen pada kasus gagap di
Indonesia, dan faktor yang memengaruhi ekspresi gen tersebut.
TINJAUAN ETIK DAN HUKUM TERHADAP VAKSINASI COVID-19 ANTARA
PILIHAN DAN KEWAJIBAN
Authors: Ramdhani Sony
Published: January 2023

Pandemi Corona Virus Disease 2019 (COVID-19) merupakan wabah penyakit disebabkan oleh
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) yang diidentifikasi sebagai
virus corona jenis baru. Jenis yang baru ini mempunyai sifat berbeda yaitu lebih menular
dibandingkan yang sebelumnya walaupun masih dalam famili yang sama. Dalam penanganan
pandemi Covid-19 ini tidak dapat hanya dilakukan dengan mengobati yang sakit saja tetapi
harus terintegrasi, mulai dari upaya promotif, preventif, kuratif, dan rehabilitasi. Tujuan dari
penelitian ini untuk mengetahui tinjauan secara etik dan hukum analisis Peraturan Presiden No
14 Tahun 2021 tentang Pengadaan Vaksin dan Pelaksanaan Vaksinasi dalam rangka
Penanggulangan Pandemi Corona Virus Disease 2019, yang mewajibkan kepada warga yang
terdaftar sebagai sasaran vaksinasi Covid-19 dan pemberian sanksi jika tidak mengikuti
program. Metode yang digunakan dalam penulisan ini adalah yuridis normatif, yaitu melakukan
kajian dan penelaahan hukum normatif melalui studi kepustakaan. Program Vaksinasi Covid19 merupakan pelaksanaan kewajiban pemerintah dalam rangka pemenuhan hak manusiawi
warganya agar dapat menjalani hidupnya dengan rasa aman, tenteram, sehat dan sejahtera.
Secara prinsip hukum sudah sesuai dengan UUD 1945 sebagai sumber hukum serta peraturan/
undang-undang lainnya, sehingga pemerintah dapat memaksa warganya untuk mengikuti
program vaksinasi, sedangkan untuk pilihan hanya pada jenis vaksinnya. Berdasarkan prinsip
etik maka Program Vaksinasi Covid-19 telah memenuhi artikel/pasal yang terdapat dalam
Universal Declaration on Bioethic and Human Right, dan kaidah dasar moral beneficence,
nonmalficence, autonomy, dan justice dengan primafacienya adalah Justice, diharapkan pada
pelaksanaannya tenaga kesehatan melaksanakan sesuai kaidah etik.
LIMFOMA TULANG YANG MENYERUPAI METASTASIS KARSINOMA TIROID
FOLIKULER: LAPORAN KASUS
Authors: Prima Muhammad Aulia , Darmawan Budi , Hidayat Basuki , Soeriadi Erwin Affandi , Kusumahstuti Kharisma Perdani
Published: January 2023

Karsinoma tiroid folikuler merupakan subtipe kedua tersering yang umumnya bermetastasis
ke tulang. Beberapa teknik pencitraaan dapat digunakan untuk mendeteksi adanya metastasis.
Kami melaporkan kasus suspek metastasis karsinoma tiroid yang kemudian dinyatakan
sebagai limfoma tulang. Wanita berusia 33 tahun dirujuk mendapatkan terapi radiotiroablasi
menggunakan NaI 131. Pasien mengeluh suara serak, kadang masih terasa nyeri pada luka
bekas operasi di leher, dan terdapat benjolan pada dahi kanan terasa nyeri. Pasien diduga
mengalami metastasis calvaria oleh pemeriksaan CTScan sebelumnya. Pasien dengan riwayat
karsinoma tiroid folikuler pasca tiroidektomi total dan mendapatkan terapi Levotiroksin
1x200mcg. Hasil TSH 0,1 uIu/ml dan Tiroglobulin <0,06 ng/ml dalam keadaan tersupresi.
Pasien diberikan terapi NaI 131 100 mCi, 48jam pasca terapi dilakukan pemeriksaan citra
planar dan SPECT/CT sidik seluruh tubuh, dengan hasil tampak adanya sisa jaringan tiroid
fungsional dan samar-samar gambaran metastasis calvaria. Kami memberi saran untuk
pengangkatan massa tumor. Pasca operasi, penilaian histopatologi menunjukkan adanya NonHodgkin Lymphoma (NHL) pada tulang. Dibandingkan dengan hasil sidik seluruh tubuh dan
CTScan didapatkan hasil yang berbeda mengenai adanya metastasis calvaria. Oleh karena itu,
pasien kami sarankan untuk pemeriksaan 18FDG-PET/CT Onkologi. Sementara itu,
kemoterapi dan radiasi eksternal direncanakan pada pasien. Kanker tiroid yang bersamaan
dengan limfoma tulang sangat jarang. Saat ini biopsi masih menjadi baku emas untuk
konfirmasi diagnosis, namun pencitraan kedokteran nuklir dapat dipertimbangkan sebagai
salah satu pendekatan diagnosis untuk membedakan suatu keganasan merupakan metastasis
dari tiroid atau bukan. 18F-FDG PET/CT dengan kemampuannya untuk mendeteksi metastasis
yang tidak dapat menangkap radioiodine. Pendekatan manajemen pasien yang tepat dapat
menurunkan mortalitas pasien dengan keganasan.
Разработка технологии хлебобулочных изделий с введением горохового гидролизата
Authors: Бычкова Елена Сергеевна , Подгорбунских Екатерина Михайловна , Рождественская Лада Николаевна , Бухтояров Владимир Александрович , Кудачева Полина Владимировна
Published: January 2023

Введение: Современные мировые тенденции употребления растительного и животного белка склоняют мировое общество в сторону превалирования потребления продуктов питания, обогащенных растительным белком. Это связано с несколькими преобладающими аспектами: получение растительного белка является более экономически выгодным, экологически безопасным и потенциально несет более ценную пищевую компоненту. Известно, что растительный белок усваивается в организме на уровне 61-80% в виду наличия антипитательных веществ и имеет неполноценный аминокислотный состав. Следует изыскивать новые научные подходы повышения биодоступности пищевых компонентов растительного белкового сырья.

Объекты и методы исследования: В статье приводится поэтапный алгоритм проектирования белоксодержащего пищевого продукта с включением в стадию разработки способа снижения антипитательных свойств растительного сырья. В качестве белкового ингредиента выбран горох, который подвергался тонкому измельчению совместно с ферментативным препаратом с последующей стадией ферментативного гидролиза при оптимальных параметрах. Гороховый гидролизат использовали в замесе дрожжевого опарного теста.

Результаты и их обсуждение: На процесс замеса теста оказывает влияние ряд факторов, которые описаны в работе в виде параметрической схемы технологического процесса. На основе структурно-параметрический анализа проведен комплексный эксперимент влияния двух варьируемых факторов (количества дрожжей и гидролизата) на количество сухого нерастворимого остатка.

Выводы: Выведено уравнение регрессии, которое позволяет анализировать технологический процесс и контролировать его. В статье приводятся данные по содержанию водорастворимых веществ, белка, свободных аминокислот в готовых хлебобулочных изделиях, которые позволяют судить об эффективности стадии механоферментативного гидролиза. Общее количество водорастворимых веществ в образцах с гидролизатом увеличивается более, чем в 2 раза. Разработка новых изделий с применением стадии ферментации – это перспективное направление индустрии питания, которое позволяет получать качественно новые изделия с высокой пищевой и биологической ценностью.
Survey on Fully Homomorphic Encryption, Theory, and Applications
Authors: Marcolla Chiara , Sucasas Victor , Manzano Marc , Bassoli Riccardo , Fitzek Frank H.P. , Aaraj Najwa
Published: January 2023

This paper comprehensively addresses homomorphic encryption from both theoretical and practical perspectives. The paper delves into the mathematical foundations required to understand fully homomorphic encryption FHE. It consequently covers design fundamentals and security properties of FHE, and describes the main FHE schemes based on various mathematical problems. On a more practical level, the paper presents a view on privacy-preserving Machine Learning using homomorphic encryption, then surveys FHE at length from an engineering angle, covering the potential application of FHE in fog computing, and cloud computing services. It also provides a comprehensive analysis of existing state-of-the-art FHE libraries and tools, implemented in software and hardware, and the performance thereof.
Competitive ability of Escherichia coli strains in the intestinal microbiota of patients with Crohn's disease and healthy volunteers: physiological, biochemical and genetic characteristics
Authors: Siniagina Maria N. , Laikov Alexander V. , Markelova Maria I. , Boulygina Eugenia A. , Khusnutdinova Dilyara R. , Abdulkhakov Sayar R. , Grigoryeva Tatyana V.
Published: January 2023

Introduction. Crohn's disease (CD) is a chronic inflammation of various parts of the gastrointestinal tract with an increased proportion of Escherichia coli. However, the role of E. coli in disease remains unclear.
This study aims to evaluate the competitive abilities of E. coli strains from CD patients and healthy volunteers, and to identify the biochemical and genetic determinants underlying these features.
Materials and methods. The antagonistic activity was assessed by co-cultivation of 11 clinical E. coli strains inhibiting the growth of the K-12, with Enterobacter cloacae, Klebsiella pneumonia and Salmonella enterica. To elucidate the mechanism of antagonistic activity, the evaluation of biochemical properties and a comparative genomic analysis were used.
Results and discussion. Genes of bacteriocin production systems were identified in genomes of 11 strains from CD patients and healthy volunteers active against the E. coli K-12 strain. Three strains from healthy individuals demonstrated activity against several Enterobacteriaceae bacteria. The strains biochemical properties were typical of representatives of E. coli. Strains 1_34_12, active against E. cloacae, and 1_45_11, inhibiting all tested enterobacteria, are phylogenetically related to the laboratory strain K-12. Strain 1_39_1, active against K. pneumonia and S. enterica, is phylogenetically close to the Nissle1917, contains the genes for colibactin biosynthesis and a variant of the fimH gene that increases the adhesive ability of bacteria.
Conclusion. The identified E. coli strains are able to displace Enterobacteriaceae bacteria and can be used to study the bacteria-bacteria and host-bacteria interactions, to understand their role in gut homeostasis and intestinal inflammation.
Mechanisms of Toll-like receptor tolerance induced by microbial ligands
Authors: Bulgakova Irina D. , Svitich Oxana A. , Zverev Vitaly V.
Published: January 2023

Some microorganisms can develop tolerance. On the one hand, it allows pathogenic microbes to escape immune surveillance, on the other hand, it provides the possibility to microbiota representatives to colonize different biotopes and build a symbiotic relationship with the host. Complex regulatory interactions between innate and adaptive immune systems as well as stimulation by antigens help microbes control and maintain immunological tolerance. An important role in this process belongs to innate immune cells, which recognize microbial components through pattern-recognition receptors. Toll-like receptors (TLRs) represent the main class of these receptors. Despite the universality of the activated signaling pathways, different cellular responses are induced by interaction of TLRs with microbiota representatives and pathogenic microbes, and they vary during acute and chronic infection. The research on mechanisms underlying the development of TLR tolerance is significant, as the above receptors are involved in a wide range of infectious and noninfectious diseases; they also play an important role in development of allergic diseases, autoimmune diseases, and cancers. The knowledge of TLR tolerance mechanisms can be critically important for development of TLR ligand-based therapeutic agents for treatment and prevention of multiple diseases.
Dynamic Vehicle Modelling and Controlling Techniques for Autonomous Vehicle Systems
Authors: R. Sushma  , J. Satheesh Kumar
Published: January 2023

The driving scenario of an automated vehicle is the crucial technology in the design of autonomous cars. This suggested approach aims to address the shortcomings of autonomous cars, such as their poor real- time performance and low control precision. The process for building a virtual simulation environment for autonomous vehicle testing and validation is described in this study. Model Predictive Control and Proportional Integral and Derivative Control are used in MATLAB simulation to build three car models. These are related to the 2D and 3D animation used in collision detection and visualization. The virtual engine visualization is included throughout the model. A variety of test circumstances are used to validate the simulation model, and the model’s performance is assessed in the presence of various barriers. The simulation's findings demonstrate that the autonomous vehicle has a strong potential for self-adaptation even in challenging and complex working environments. No instances of car sideslip or track departure have been noted. It is discovered that this autonomous car performs remarkably well overall when compared to other autonomous vehicles. The suggested approach is essential for enhancing autonomous vehicle driving safety, maintaining vehicle control in challenging situations, and improving the advancement of intelligent vehicle driving assistance.
POLÍTICA, RELIGIÃO E ESPORTES SÃO INSEPARÁVEIS
Authors: Vilela Junior Guanis de Barros , Passos Ricardo Pablo
Published: January 2023

Apesar do recorrente e infantil discurso nas mídias (rádio, TV, redes sociais, jornais etc.) que política, religião e esporte não se misturam, ou pior, não devem ser misturados, a realidade mostra o contrário, afinal, jogadores fazem preces antes do início de vários tipos de disputas esportivas; alguns se prostam ajoelhados e com as mãos apontadas para o alto agradecendo o seu Deus por uma vitória de seu time; vários deles tatuam seus corpos com símbolos religiosos e outros tantos, usam adereços de puro ouro dependurados no pescoço e até nas orelhas. Torcedores são flagrados nas arquibancadas com as mãos em posição de prece no instante daquele momento decisivo da partida. As evidências empíricas de que religião e esporte estão profundamente misturados é inquestionável. Por sua vez, a ligação entre política e esporte é mais forte, em qualquer campeonato mundial de qualquer esporte, toca-se o hino nacional da nação que ganhou o primeiro lugar, ali, os atletas-guerreiros representam a sua nação e os valores políticos, morais e sociais dela. Esportistas campeões mundiais de várias modalidades esportivas são tratados como deuses em seus países, legítimos representantes da guerra entre nações mimetizada pelos esportes. Não, não se trata de um discurso bélico dos esportes, a questão parece ter raízes muito mais profundas, trata-se também de uma suposta hegemonia que uma nação pensa ter em relação a outros países, numa aflita tentativa em deixar claro o recado: nós somos os melhores do mundo e o mundo se espelha em nosso país. Portanto, a negação de que esporte, política e religião não se misturam, configura um discurso que aponta para uma visão de mundo fragmentada, potencialmente manipuladora, que parte do pressuposto da existência de uma estupidez que, talvez, a maioria das pessoas no mundo não tenha. A apologia deste suposto analfabetismo político e teológico, não combina em nada com um mundo hiper conectado, mas também, claramente polarizado, com nações e sociedades de matrizes religiosas que vão da cristandade, passando pelo judaísmo e islamismo, até os hinduístas, budistas, xintoístas, e várias outras, não hegemônicas, mas também igualmente importantes. Na política, nações ditas democráticas, as sociais-democracias, os regimes totalitários e os populistas, todas, sem exceção, ufanistas de seu sucesso e escravas do capitalismo financeiro, mediático e informacional. A falácia do esporte desvinculado da política e religião é tão ingênuo, ou maldoso, quanto supor que beber leite com manga pode matar. Neste modesto exercício de livre-pensar, será realizada uma possível, mas não universal, reflexão sobre os espetáculos esportivos que consumimos, temperados com política e religião.
The model of integration of traditional and distance learning of foreign languages at high school level
Authors: Trubina Zoya I. , Melnikova Irina Y.
Published: January 2023

The paper discusses the technology of remote learning, namely one of its models - the integration of traditional and distance learning. This technology is based on the transfer of certain types of activities and part of the study material into a distance form. The subject of the study is the features of the integration of traditional and distance learning forms of English language teaching in high school. The aim of this research is to consider the theoretical aspects of distance learning and develop methodological recommendations for the integration of traditional and distance forms of foreign language teaching in high school. The theoretical significance of the work is determined by the fact that it makes a certain contribution to the methodological development and systematization of the study of distance learning, including the introduction of this form in the conditions of online interaction, which can be used for teaching other subjects and languages. The practical significance of the study consists in the possibility of using the model of integration of traditional and distance forms of education directly in foreign language lessons, as well as an additional material for improving the qualifications of teachers on the stated issues. The methodological basis of the research includes the works of G. A. Bordovsky, M. V. Klarin, S. L. Lobachev, M. H. Lutfillaev, E. S. Maslakov, E. I. Mashbits, R. P. Milrud, A.V. Khutorskoy, and others devoted to the didactic aspects of computerization of education. The works of T. Anderson, A.V. Bykov, C. Wedemeyer, L. I. Zheludkova, V. Kukharenko, N. Morse, M. Moore, V. Ovsyannikov and others should also be noted. The research methods are the analysis of psychological, pedagogical and methodological literature on the topic, logical argumentation, proof, generalization, justification, synthesis, reflection, description.