bluuebunny/crossref_metadata_2025 huggingface dataset:
MetaboAtlas21: A comprehensive metabolome and lipidome atlas of mouse tissues and biofluids
Authors:   Institute of Physiology of the Czech Academy of Sciences, Cajka Tomas , Hricko Jiri , Rudl Kulhava Lucie , Novakova Michaela , Paucova Michaela , Kuda Ondrej
Published: November 2022

Here, we present a specific atlas of mouse metabolome and lipidome (MetaboAtlas21) in the context of systemic energy balance (chow diet) and under chronic nutrient stress (high-fat diet). Male mice were fed a control (chow) diet for 2 months or a high-fat diet for 2 months and 10 months. Urine, plasma, feces, and 18 different tissues were collected from each animal for metabolomics and lipidomics analysis. These matrices cover digestive, excretory, respiratory, reproductive, endocrine, muscular, cardiovascular, and nervous systems. Also, chow and high-fat diet feeds were analyzed along with quality control human plasma/serum materials (NIST SRM 1950 plasma, Merck S1-100ML serum, Sigma–Aldrich S7023 serum). In total, 408 samples were included in this study. An “all-in-one” extraction protocol LIMeX using methyl tert-butyl ether, methanol, and water was used to isolate metabolite fractions and analyzed using a multiplatform LC-MS-based approach (7 platforms for non-fat tissues and biofluids; 8 platforms for adipose tissues). Raw data files were processed using MS-DIAL 4. Metabolites were annotated using in-house retention time–m/z library and using MS/MS libraries available from commercial and open sources (NIST20, MassBank, MoNA). Lipids were annotated using LipidBlast in MS-DIAL. Ultimately, we annotated over 3,000 unique polar metabolites and complex lipids. To better understand the structure of generated data, we provide a user-friendly data visualization tool (metaboatlas21.metabolomics.fgu.cas.cz) to easily access and analyze the different combinations of tissues and biofluids in response to the metabolic challenge (NIST20, MassBank, MoNA). Lipids were annotated using LipidBlast in MS-DIAL. Ultimately, we annotated over 3,000 unique polar metabolites and complex lipids. To better understand the structure of generated data, we provide a user-friendly data visualization tool (metaboatlas21.metabolomics.fgu.cas.cz) to easily access and analyze the different combinations of tissues and biofluids in response to the metabolic challenge.
Demystifying chemometrics: how multivariate analysis allows spectroscopy to be used to solve most analytical problems
Authors:   Keit Spectrometers, Speed Jonathon
Published: November 2022

Chemists have been using spectroscopic techniques for decades if not hundreds of years. The large range of different physical transitions nuclei and molecules can undertake when irradiate with specific wavelengths of light means that almost every property of interest can and has been studied by spectroscopic means. However, the need to interpret the raw spectra means only specialists are able to interpret the fundamental information present in a spectrum, turning spectroscopy into a tool for experts. The advent of chemometrics meant that spectrometers could be changed into concentration meters, allowing a user to run a previously built calibration curve and understand the makeup of their sample. As a result, many industries now have a dwindling pool of spectroscopy “power users” and have retired their powerful instruments into pre-determined QC tests. This presentation aims to educate and empower the attendees as to the power of spectroscopy, and the different types of analysis it allows, ranging from fundamental chemical makeup through to on-line and real-time processing analysis for industrial installations. We will briefly outline the different types of spectroscopy commonly used in laboratories and on-line, and explain their strengths and weaknesses. Next, we will explain the fundamentals behind multivariate analysis, focusing on principal component analysis (PCA) and partial least squares (PLS) methodology as well as multivariate curve resolution (MCR). We will then explain how chemometrics can be used to investigate in detail what is occurring during a process, how the advanced statistics generated on every spectrum allow in depth analysis of the process (for example how to properly use Hotelling’s T2 and Q Residuals) and give some case studies.
Selective synthesis of alpha monoglycerides by clean method: Techno-economic and environmental assessment
Authors:   October University for Modern Sciences and Arts (MSA), Mustafa Ahmad , Niikura Fumiya ,   Lion Corporation, Mohsen Reham ,   October University for Modern Sciences and Arts (MSA)
Published: November 2022

This work proposes an alternative green and selective biocatalytic route for α-monostearin production. The production process was performed by esterifying stearic acid with glycerin in an organic medium using Candida antarctica lipase (Novozym 435) at a mild temperature. The reaction conditions were optimized using the RSM: optimum conditions were a temperature of 60 °C, glycerin to stearic acid molar ratio of 8:1, and Novozym 435 amount of 6% w/w. The solvent addition remarkably improved the α-monostearin yield to nearly 80% without the need for the energy-intensive distillation step. The conventional autocatalytic esterification (AUT) process was also performed to investigate the comparative monoglyceride yield, and it was found to be 22.5%. 1NMR and GC confirmed that α-monostearin could be produced with the highest purity using the proposed enzymatic method (ENZ). Economic and environmental analyses were also conducted for the proposed ENZ process, and the results were compared with those of the AUT process. Total capital investment of α-monostearin production, considering a projected capacity of 4950 t year–1 and 11% interest for the proposed ENZ process, was favorably 2.5 times lower than that of the AUT process, suggesting a promising investment opportunity. However, the total production costs showed unfavorable negative net present value (NPV) and return on investment (ROI) for the ENZ process and favorable positive NPV and ROI for the AUT process, indicating that the proposed venture is not profitable for α-monostearin production. However, the process can be profitable at improved operational stability of Novozym 435 up to 1 kg per 3-ton product. The carbon footprint was calculated on the basis of the given capacity and conditions of 50 and 656 t CO2 eq./year for the ENZ and AUT processes, respectively. The synthesis of α-monostearin using the proposed route can be considered a building block toward a cleaner large-scale production of α-monoglycerides.
Determination of 3-MCPD and glycidol in food emulsifiers: Analytical solution and multi-laboratory validation
Authors:   SGS Germany GmbH, Kuhlmann Jan
Published: November 2022

3-monochloropropane-1,2-diol (3-MCPD) and glycidol are potentially harmful substances which might occur as fatty acid esters (3-MCPDE and GE) in various foods. Major source for these food-borne contaminants is elevated heating in course of refining and processing of edible oils and fats. In this context, it seems to be important to recognize certain edible oil-based food emulsifiers, especially mono- and diacylglycerides (MAG and DAG), to be a relevant source for GE and 3-MCPDE. Due to the potential risk for consumers, the European Commission issued a regulation on GE and total 3-MCPD (which stands for the sum of free 3-MCPD and 3-MCPDE) in certain foods. By regulation EU 2020/1322 maximum levels of total 3-MCPD and glycidol are set for marine and vegetable edible oils as well as infant formula. Recently, expansion of this regulation to a number of other processed foods as well as food emulsifiers is discussed by official bodies and stakeholders. In perspective of consumer’s increasing demands for food quality, several food producers and retailers have set internal maximum levels for 3-MCPD and glycidol in their products. Correspondingly, for the food industry as well as for authorities there is a demand for analytical methods which are applicable to food emulsifiers. Unluckily, food additives were in general not in the scope of any of the officially validated methods for determination of total 3-MCPD and GE. Moreover, it has been reported that the most abundant official methods might give unreliable results for GE, especially with MAG and DAG. This presentation targets the introduction of an AOCS Official Method Cd29b-13 (equal to ISO Standard 18363-2) adaption for analysis of certain food emulsifiers and its successful validation by a multi-laboratory trial.
A nondestructive method for oil distribution evaluation in healthy fried food developing by Raman imaging
Authors:   Wilmar (Shanghai) Biotechnology Research & Development Center Co., Ltd, Tong Peijin , Iiang Junmei ,   Wilmar Global R&D Center, Wei Lingling , Cao Wenming ,   Wilmar (Shanghai) Biotechnology Research & Development Center Co
Published: November 2022

Deep-fat frying is one of the most popular food processing methods worldwide, which makes fried products tend to have bright color, delicious taste and crisp texture. However, traditional fried foods contain large amount of oil, calories and acrylamide which are burden to health, making consumers increasingly tend to use healthy food with low fat content, reduction of oil uptake during different frying processes is necessary. In this study, fried spring roll wrappers at different temperature were taken as examples to be investigated by Confocal microscopic Raman imaging method. The Raman spectra measured within the fried wrapper were compared with spectra of the main components i.e., raw wrapper and frying oil. In this way, the oil distribution in longitudinal section of the wrappers were determined and corresponding images of the fried wrapper microstructure were generated. Comparing to the commonly used oil distribution detection method of dye oil coupled with confocal laser scanning microscopy (CLSM), Raman imaging method shows great advantages in nondestructive, dye reagent free and can eliminate possible influences of oil dye reagent during frying process. The research showed that Raman imaging method has great potential in analyzing oil infiltration mechanism during frying and help to develop innovative frying technologies to reduce oil absorption during frying process, thus obtain healthier fried products with low oil content.
Understanding interfaces: Using contact angle measurements to determine surface tension, interfacial tension, and kinetic properties from contact angle hysteresis
Authors:   DataPhysics Instruments USA Corp., Scholz Daniel , Simutis Paul
Published: November 2022

When there is an interface between a liquid and a solid, the angle between the surface of the liquid and the baseline of the contact surface is described as the contact angle. The contact angle is a measure of the wettability of a solid by a liquid. Measurement of the contact angle helps in all situations where solids and liquids meet and there is benefit gained by control of wetting and adhesion properties. Applications where contact angle values are especially important include development of hydrophobic or hydrophilic surface coatings, paints and varnishes, cleaning agents, printing processes, and more. Contact angle goniometers are high-precision video camera-based devices which perform the optical analysis of the shape of liquid drops placed on a solid surface (sessile drop method) or the shape of drops that hang down from a dosing needle (pendant drop method). The drop shape helps in determination of different surface and interfacial parameters such as surface tension of a liquid, interfacial tension between two liquids, and surface energy of solid substrates. Contact angle hysteresis is an important physical phenomenon arising from chemical inhomogeneities, roughness, or impurities on a surface which can affect how a liquid droplet spreads across a surface. Contact angle hysteresis is the difference between advancing and receding contact angles and can be measured using the “needle-in method” or by tilting the actual contact angle goniometer or sample stage itself, allowing the droplet to roll across the surface of the substrate. This paper will describe recent advances in contact angle goniometry and will explain how surface tension, interfacial tension, and contact angle hysteresis measurements can be easily and accurately made using a modern contact angle goniometer and software.
Lipid oxidation in sorted herring (Clupea harengus) filleting co-products and its relationship to composition
Authors:   Chalmers University of Technology, Wu Haizhou , Forghani Bita , Undeland Ingrid , Abdollahi Mehdi
Published: November 2022

In industrial fish filleting, around 30–70 % of the total weight of the fish end up as side streams (often called by- or co-products), such as the head, backbone, caudal fin, skin, and intestines. Currently, these fractions are dedicated to low value uses as fodder meals or mink feed, even if they contain significant amounts of protein, long chain (LC) n-3 polyunsaturated fatty acids (PUFA), and other nutrients such as vitamins and minerals. However, most fish processors mix their side streams, not least when it comes to small pelagic species like herring. This practice limits use of the side streams for food production since the raw material gets very complex, and since blood, enzymes and lipids from e.g., the viscera and head parts easily contaminate the cleaner parts like the backbones and tails, accelerating e.g., their oxidative or enzymatic degradation. In the present study, lipid oxidation in ice-stored sorted and minced herring fractions (head, backbone, viscera+belly flap, tail, fillet) from spring and fall, and its association with endogenous pro-oxidants, antioxidants and lipid substrates were investigated. Peroxide value (PV) and thiobarbituric acid reactive substances (TBARS) had increased significantly in all fractions after 1 day, but for both seasons, the most rapid PV and TBARS development occurred in head, which also had highest hemoglobin (Hb) levels and lipoxygenases (LOX) activity. Viscera+belly flap was overall the most stable part, and also had the highest -tocopherol content. Pearson correlation analyses across all five fractions confirmed a significant impact of Hb, LOX and -tocopherol on the lipid oxidation susceptibility, while content of total iron, copper, lipids or PUFA provided no significant correlation. Overall, the study showed which pro-oxidants that should be inhibited or removed to succeed with value adding of herring filleting side streams along with the fillet itself.
Filterability of oil slurries as a function of particle-size distribution
Authors:   AAK Denmark AS, Hjorth Jeppe
Published: November 2022

Objective: In dry fractionation, the filterability of an oil slurry determines the quality of the separation, the quality of the resulting fractions and thus the profitability of the process. Therefore, this parameter is pivotal for obtaining the best and most efficient fractionation. To date the quality of a dry fractionation process has indirectly been assessed by comparing viscosity and SFC of the oil slurry. In this study, it was evaluated whether specific features from the crystal-size distribution of a given oil slurry could be correlated directly to the observed filterability. Filterability, SFC, viscosity and crystal-size distribution were measured for a number of fractionation experiments with different isothermal holding temperatures and crystallization times. The filterability was described as filtered volume of olein per time and the crystal-size distribution was measured continuously using Mettler Toledo’s Particle Track equipment.A strong correlation was observed between the filterability and the quality of the stearin cake. The crystal-size distribution changed significantly based on the length and isothermal temperature of the experiment. By assuming spherical geometry and calculating total-surface area and volume of the crystals it was possible to describe the observed SFC and viscosity and furthermore there was a good correlation between the total crystal-surface area and the filterability. The measured crystal-size distribution could be translated into meaningful physical properties of the oil slurry in question. Said distribution can therefore be used as a time-dependent output to follow the crystallization process and pinpoint optimal filterability.
Rapid Small Scale Oxidation Test: Screening the Influence of Antioxidants on Food Products
Authors:   ANTON PAAR PROVETEC GMBH, Edinger Carolin , Paar Anton
Published: November 2022

The quality of fats, oils, and food products in general strongly depends on their oxidation stability. In this contribution a new method for evaluating the oxidation stability of food products by determining the induction period is introduced. Under accelerated conditions (elevated temperature and pure oxygen pressure) a sample of 5 mL/4 g is examined in a sealed stainless steel test chamber. Typical conditions of the method are temperatures between 80 °C–140 °C and an initial oxygen pressure of 700 kPa. These conditions initiate a rapid oxidation process, which is monitored by recording the pressure until a predefined pressure drop. It was found that the elapsed time until the pressure drop is directly related to the oxidation stability of the sample. Due to the defined oxygen volume in the closed test chamber, the oxygen consumption can be calculated. Beneficially, the oxidation stability of complex food products can be investigated since even solid samples can be measured without prior sample preparation. Application examples demonstrate the broad variety of samples and the effectiveness of the method when it comes to antioxidant screening. The significantly reduced measurement time and a high repeatability of the method represent its major advantages when it comes to screening the effect of antioxidants.
Comprehensive analysis of lipids: From plant oil analysis towards lipidomic cancer screening
Authors:   University of Pardubice, Holcapek Michal
Published: November 2022

The analysis of lipids as biomolecules involved in numerous metabolic pathways has attracted my attention since the beginning of my scientific carrier. My first article was published in 1999 on the monitoring of biodiesel production by LC/MS [1] and then continued with further work on the detailed characterization of triacylglycerols in plant oils and animal fats. We developed various LC/MS methods for the analysis of all existing types of triacylglycerol isomers, including regioisomers, double bond (DB) positional isomers [2], DB geometrical isomers [3] up to enantiomers [4]. Later, we moved towards comprehensive lipidomic analysis of multiple lipid classes of phospholipid, sphingolipid, glycerolipid, fatty acyl, and sterol categories with the emphasis on validated quantitative workflows applicable in clinical analysis [5]. The development of LipidQuant 1.0 tool for automated processing of lipidomic data [6] was essential for high-throughput analysis of large clinical cohorts. Finally, the lipidomic profiling of human serum enabled the early detection of pancreatic cancer patients [7]. A similar pattern of lipid dysregulation was observed for other types of cancer [8]. References [1] Holčapek, M. et al., Anal. Chem., 858, 13–31. [2] Lísa, M.; Holčapek, M., Anal. Chem. 2008, 1998–1999, 115–130. [3] Lísa, M.; Velínská, H.; Holčapek, M. Anal. Chem., 81, 3903–3910. [4] Lísa, M.; Holčapek, M. Anal. Chem. 2013, 85, 1852–1859. [5] Holčapek, M.; Liebisch, G.; Ekroos, K. Anal. Chem. 2018, 90, 4249–4257. [6] Wolrab D. et al., Bioinformatics 2021, in press. DOI: 10.1093/bioinformatics/btab644. [7] Wolrab D. et al., Nat. Com. 2021, final revision. Preprint at medRxiv DOI: 10.1101/2021.01.22.21249767. [8] Wolrab D., 11, 20322.
Cashew NutSell Liquid (CNSL), a promising source of biobased additives and building blocks for the industry
Authors:   Orpia Innovation, Briou Benoit , de Gartili Adélaïde , Roy Audrey , Jego Lucas
Published: November 2022

CNSL is a crude oil extracted from cashew nutshells. Among the renewable resource materials available, CNSL is considered as an important starting material due to its abundant availability and low cost. Depending on the extraction method, it is possible to obtain an oil with different grades of quality. Once purified, bio-based phenolic compounds of great interest are isolated: cardanol, cardol, and anacardic acid. Many and diverse reactive sites are present on these molecules such as aromatic ring, phenolic hydroxyl, carboxylic acid, and an unsaturated long alkenyl side chain. Their peculiar structures induce some pertinent properties, allowing a good compromise between flexibility and thermal stability. Several platform molecules for the synthesis of additives or monomers have been made by chemical transformation respecting the principles of green chemistry as far as possible. surfactants, plasticizers, paint binder, hardening agents and polymers have been developed from this multi-skilled natural resource.
Simultaneous loading of (–)-epigallocatechin gallate and ferulic acid in chitosan-based nanoparticles as effective antioxidant and skin-whitening agent
Authors:   Jinan University, Li Guanghui , Qiu Chaoying , Liu Ning ,   Shaanxi University of Science and Technology, Lu Xuanxuan ,   Jinan University
Published: November 2022

A chitosan (CS) based nanoparticles simultaneously loaded with (–)-epigallocatechin gallate (EGCG) and ferulic acid (FA) was synthesized via ionic gelation reaction between chitosan and sodium tripolyphosphate and subsequent modification by genipin. Average particle size, chemical structure, morphology, rheological properties, entrapment efficiency, in vitro anti-oxidative and tyrosinase inhibitory activity of CS nanoparticles were investigated. Results showed that the nanoparticles showed an ellipsoidal shape with an average diameter of 412.3 ± 3.5 nm, and zeta potential of 35.47 ± 0.90 mV with high DPPH and ABTS·+ scavenging ability. The entrapment efficiency of EGCG and FA were 46.0 ± 1.32% and 46.8 ± 1.64% in the nanoparticles, respectively. Cytotoxicity experiment on NIH 3T3 fibroblast cells reveals that CS based NPs show no toxic effects with concentration less than 200 mg/mL–1. Meanwhile, the nanoparticles improved cell viability from ~65% to 105% and ameliorated the morphological damage by H2O2. Moreover, it showed a higher tyrosinase inhibitory activity compar-ing with blank NPs without bioactives and a commonly used bioactive compound kojic acid (P < 0.05), suggesting the good skin repair and whitening effects of nanoparticles. This research would provide new insights and basis for the designation of novel particles which can be applied as Pickering stabilizers loaded with dual bioactive agents with beneficial activities.
Bio-based cationic waterborne polyurethane dispersions from high oleic soybean oil
Authors:   Politecnico di Torino, Dalle Vacche Sara
Published: November 2022

Polymeric materials are under tremendous pressure for improving their greenness: despite their important role in several essential aspects of human life, in public opinion they are mostly associated with single-use plastics pollution and use of fossil resources. Sustainable polymer-based materials may be prepared from biobased monomers and polymers, through photoinduced processes. Owing to low energy requirements, high reaction rates at room temperature, and low VOC emissions, photoinduced polymerization is recognized as a green technology. Among the biobased monomers explored in this field, those derived from cardanol (a natural phenolic lipid obtained from cashew nutshell liquid) and from unsaturated vegetable oils, such as soybean oil, are interesting for industrial applications, being commercially available. However, polymers obtained by photoinduced polymerization of biobased monomers often have low thermomechanical properties; biobased monomers are thus typically used as co-monomers to increase the biobased content of fossil-based polymers, in non-structural applications, such as coating or adhesives, or are added with reinforcements to obtain composite materials. The latter option is particularly interesting when natural fillers, such as cellulosic fibers, are used, thus obtaining fully biobased composites. In our group we exploited photoinduced reactions to produce composites from biobased monomers, using wood-based microfibrillated cellulose and nanocellulose from hemp waste fibers as reinforcements. Two routes were explored: (i) epoxidized and (meth)acrylated monomers derived from cardanol and from soybean oil, were polymerized by photoinduced radical or cationic chain growth reactions; (ii) copolymer latexes obtained from derivatives of eugenol and coumarin were crosslinked through a photocycloaddition reaction. In the latter case, the potential reversibility of the crosslinking was explored in view of recyclability. The photoinduced polymerization and crosslinking reactions were studied by Fourier Transform Infrared (FTIR) and UV-visible spectroscopies; high degrees of conversion were obtained. The thermal, mechanical, and functional properties of these composites make them interesting for e.g., packaging applications.
Single-wavelength near-infrared analysis as a rapid and field-deployable tool to determine the solid fat content in fats and oils
Authors:   Alma Mater Studiorum—Université di Bologna, Valli Enrico , Ricco Bruno , Grossi Marco , Rocculi Pietro , Gallina Toschi Tullia , Teresa Glicerina Virginia
Published: November 2022

The solid fat content (SFC) is responsible for the characteristics and properties of a variety of fat-based food products, since it provides information, among others, on physical appearance, organoleptic properties, spreadability, product stability mouth feeling, and plasticity. The traditional techniques to measure SFC, such as pulsed nuclear magnetic resonance and differential scanning calorimetry, require expensive instrumentation and trained personnel. Nowadays innovative techniques are needed for fast, automatic, and low-cost in situ, determination of SFC directly in the production lines to allow food quality monitoring in control industrial processes. This is very relevant for small and medium food industries that cannot afford an internal quality control laboratory. An innovative near-infrared analytical approach to measure SFC in vegetable fats and oils is herein presented. The method is based on single-wavelength (835 nm) and measures the sample optical attenuation during a thermal cycle (featuring both heating and cooling). An estimation of SFC is then made from the measured optical data. Samples were a set of 16 different vegetable fats and oils commonly used in the food industry, such as cocoa butter, refined and fractionated coconut oils, hydrogenated palm and soybean oil, as well as blends among them. The estimated temperature corresponding to an SFC of 80%, 60%, 40%, and 20%, respectively, was plotted versus the corresponding temperature resulting from DSC curves for all tested samples. The experimental results obtained with such a method agree with those provided by DSC at different temperatures (R2 > 0.9), thus reaching a good SFC estimation. This indicates that the single-wavelength near-infrared technique is promising for practical analysis in the production lines to assess the quality of vegetable fats and oils. The herein-tested analytical solution could be implemented in the form of a low-cost and portable electronic system.
Exploration of a remote swallowing training model after laryngeal cancer surgery during the COVID-19 pandemic (Preprint)
Authors: Li Nuan , Huang Junwei , Guo Wei , Huang Zhigang
Published: November 2022

BACKGROUND

Patients with supraglottic laryngeal carcinoma have the need to receive swallowing rehabilitation training, and during the COVID-19 pandemic patients do not have the conditions to come to the hospital frequently for follow-up, so it is imperative to explore a new remote rehabilitation training model based on network conditions.

OBJECTIVE

The aim was to explore the effect of remote rehabilitation training mode on the improvement of postoperative swallowing function in patients with supraglottic laryngeal carcinoma.

METHODS

Patients with supraglottic laryngeal carcinoma were divided into an experimental group receiving remote rehabilitation training (n=16) and a control group receiving video rehabilitation training (n=16). Baseline assessments of subjective and objective swallowing function were performed during the first week after the start of postoperative transoral feeding, swallowing function rehabilitation training was started, and patients' swallowing function was monitored again one week and three weeks after the intervention to compare the improvement of swallowing function and vocalization of complications related to swallowing disorders.

RESULTS

Patients in the experimental group began to show significant improvement in subjective swallowing function from the 2nd week (P<0.05). The improvement of both subjective and objective swallowing function in the experimental group was significantly better than that in the control group throughout the rehabilitation training process (P<0.05). The overall swallowing function of the experimental group was better than that of the control group in the 4th week (P<0.05). At the end of the rehabilitation training, patients in the experimental group had better nutritional status.

CONCLUSIONS

The remote rehabilitation training model has an improving effect on patients with supraglottic laryngeal cancer postoperative swallowing disorder, which provides a theoretical basis for the design and improvement of the future remote rehabilitation training model. This study suggests that this training model should be incorporated into the daily postoperative management of laryngeal cancer patients to improve the efficiency of patients' recovery, provide patients with real-time medical information, and relieve patients' anxiety, thus reducing the need for repeated visits and improving patients' postoperative quality of life.
Laboratory Employee’s Perspective of Artificial Intelligence Application in Clinical Labs
Authors: Shami Ashjan Ali
Published: November 2022

The advancement of the clinical laboratory technology and the emerging of artificial intelligence (AI) has improved the clinical laboratory workflow. AI provided high quality outcomes and reduced cost and time consumed compared to manual test. This study aimed to assess clinical laboratory employee knowledge and attitude toward AI implementation in workplace. An online questionnaire was published online, and responses were collected from 52 laboratory employee including trainee, lab specialist and academic faculty. The results of this study showed that the majority 83% of the respondents believed that the use of AI in clinical labs is important due to its efficiency. 75% of the respondents admitted that the AI would have an impact on hiring in the future as there will be no need for human force to operate these devices. Also most of the respondents feared that AI would replace them in the near future. In addition, most of the respondents were unaware of the AI pros and cons indicating a need for training. To summarize: in order to implement AI in clinical laboratory, employees might need to be more educated regarding to the new technology to evaluate clinical trial opportunities.
A Gateway of Sustainable Development: Nep 2020
Authors: J Mishra Prof. Pratibha
Published: November 2022

Learning takes us to immortality. Education leads to research and learning leads to consciousness. Youth will become self-reliant through National Education Policy 2020. It is our responsibility to encourage the dreams of the youth. Education enables a person to identify and solve the problems of his life, society and country.Indian higher education institutions are making their place in the international rankings. We have to motivate the youth for research and innovation. National Education Policy 2020 takes education out of the narrow circle and connects it with modern ideas. Our higher educational institutions have to present their research results with evidence so that the credibility of our research in the world increases. .The National Education Policy 2020 emphasizes on the use of technology in education. Every decade a new system comes for knowledge up gradation. In the aftermath of the global pandemic COVID-19, there is no other option except the use of technology from continuous to blended learning.There were three stages in this process of education—Shravan, Manana and Nididhyasana. Hearing means receiving knowledge through all the senses. Manan means the process of thinking, contemplating, brainstorming, etc. Nididhyasana means to bring the heard knowledge into one's life through contemplation or to give it practical form. He said that the biggest challenge before the country and the world today is a crisis of character. At the root of most of the problems of the country and the world is the crisis of character. Our education system needs to return to this basic goal. The National Education Policy-2020 has accepted this very well.The National Education Policy 2020 has focused on e-content and resource based learning through technology enabled learning so that young students are prepared according to the current requirements of the industry. Emphasis has been laid on employable education for entrepreneurship development.
Project Team Management: The significance of various leadership approaches in work environments when managing ICT project teams
Authors: Ismael Zain Noori
Published: November 2022

Although the majority of project teams perform better when leadership is shared (rather than centralized with the nominal team leader), team leaders are frequently unprepared to assess leadership potential or share leadership responsibility. The study applied quantitative research method by using online survey to analyze the significance role of various leadership in managing ICT project team. The findings revealed that leadership had a significant role in managing ICT project team. In conclusion, firms should invest in developing digital leaders who will champion digital competence and entrepreneurial processes in the design and implementation of IT solutions. This may push certain government officials to step outside their usual sphere of technical expertise. Therefore, it's crucial to recognize and promote the required change in skill levels. If a company cares about its key leaders, it should think about giving them chances to improve their communication, delegation, and motivation skills through professional development.
The Criminal Liability of Legal Entities for Environmental Crimes from the Perspective of the Brazilian Supreme Court
Authors: Bianchini Marcos Paulo Andrade , Araújo Giselle Marques de , Oliveira Ademir Kleber Morbeck de , Matias Rosemary
Published: November 2022

The research analyzed the jurisprudence of the Federal Supreme Court in the judgment of Extraordinary Appeal No. 548.181, from the State of Paraná, which overcame the understanding signed by the Superior Court of Justice, in the judgment of Ordinary Appeal in Writ of Mandamus No. 27.593 from the State of São Paulo, which dealt with the criminal liability of legal entities due to the practice of environmental crimes. The objective was to verify whether the liability imposed on legal entities was effective or whether it was reduced to a merely symbolic aspect. The work was developed through the dialectic method, which allows the questioning of the certainties established up to that point, enabling us to deny them and, from this intellectual exercise, to extract secure knowledge. It was concluded that the imputation of criminal liability to legal entities reveals itself as symbolic legislation that translates into an illusory action of the State with the purpose of conferring a way of solution to the problems and challenges for the protection of the environment, making it necessary that the discussions advance searching for more efficient answers for ecological tutelage.
The conflict of Reality and Thought in Mrs Dalloway as inspired by Virginia Woolf’s Life
Authors: Parmar Vidushi
Published: November 2022

The paper delves into the ocean of reality and thought as they exist in coordination as well as paradox in Virginia Woolf’s one of its kind novel Mrs. Dalloway. It also aspire to understand the deeper reasons that lead to Virginia writing such characters which seems far apart in their experience but are uniquely similar when seen from the lens of thought. Virginia’s personal life effected the characters consciousness, and their reactions to certain situations also find root in her own life. The concept of stream of consciousness was not new in the twentieth century but its employment was certainly unique in Mrs Dalloway, which made it popular among the public in general. It endeavour to understand the characters of Clarissa and Septimus in relation with Virginia’s interpretation of “stream of consciousness”, and the depiction of reality as driven by Virginia’s life and thought process.
The Waste Land by T.S. Eliot as a modern epic
Authors: Kumar Mr. Rabichandan
Published: November 2022

‘The Waste Land’, of course by T. S. Eliot has been treated as the magnum opus of T. S. Eliot on account of its big canvas, wide range of themes, saga of suffering, with epic grandeur. It concludes with an optimistic note- “ Shantih, Shantih, Shantih'' as well as “Da, Datta, Dayadhvam'' The mental journey from ‘The Burial of the Dead’ to ‘What the Thunder Said’ via ‘A Game of Chess’, ‘The Fire Sermon’ and Death by Water’ undertaken by Tiresias symbolizes the journey of the Christiana in John Bunyan’s ‘Pilgrim’s Progress. In Spite of this, the complexity of theme prompted a sensitive Hindi poet Nirala to remark- “ Kahan ka ianta kahan ka roda, T. S. Eliot ne kunwa joda'' The elegiac note of the opening part visualizes ‘a ray of hope’ when the poet refers to ‘the Holy river’ Ganga and the Himavant i.e. the snowbound mountains in Himalayan Ranges. Suddenly, the attention is shifted towards the famous fable of the ‘Brihadaranyaka Upanishad’ The three-fold offspring of the Creator, Prajapati, Gods, men and demons; these three approached Prajapati for instruction after completing their formal education. To each group, He uttered the single syllable ‘Da’. The message was sent to all three in the form of encoding but they interpreted or decoded in their own ways. The Gods decode it as ‘Damyata’ (Control Yourselves). The Gods decoded it as ‘Datta’ (give). The demons interpreted it as ‘Dayadhvam’ ( be compassionate). When these three meet Prajapati, aware of their interpretations, He responds with ‘OM’ signifying that they have fully understood. This concludes with the thrice repetition of thunder - Da. Da. Da. viz, control yourselves, give, be compassionate.This episode reminds us of T.S. Eliot’s focus on Charles Lanman, his Sanskrit teacher at Harvard University who gave Eliot a copy of ‘Vasudev Lakshman Shastri Phansikar’s Sanskrit edition of ‘The Twenty Eight Upanishads'. While interpreting ‘Dayadhvam”, Eliot refers to Dante’s Ínferno’Book 33, line 46 - “And below I heard the outlet of / The horrible tower locked up”. These words are uttered by Ugonio della Gherardesca, a 13th century Italian novelist as he recalls his imprisonment in a Tower with his two sons and two grandsons where they starved to death. This allusion communicates a sense of finality and suggests the terrifying consequences of imprisoning oneself within one’s own ego or consciousness. Eliot feels that only by confining to one’s own faith one is ought to transcend the boundaries of tradition. According to the European tradition or Christianity ‘Shantih ‘has been interpreted as ‘Peace Which passeth understanding ' . Indeed, It is a feeble translation of the inherent meaning of the world. Eliot anticipates something absolute and sublime as has been suggested by the Upanishadic Connotation. To conclude it can be said that this poem begins with pessimistic suffering but concludes with robust optimism.
Begleitende Evaluierung IWB/EFRE AT 2014-20. Leistungspaket 1: Prioritätsachse 1 – Forschung, technologische Entwicklung und Innovation. Endbericht.
Authors:   convelop gmbh, Melidis Konstantin , Gruber Markus
Published: November 2022

Die Geschäftsstelle der Österreichischen Raumordnungskonferenz (ÖROK GSt.) hat als Verwaltungsbehörde des österreichischen IWB/EFRE -Programms die Durchführung einer begleitenden Evaluierung des Programms beauftragt, die mit Zuschlagserteilung der Bundesbeschaffung GmbH vom 07.12.2017 an ein Konsortium bestehend aus ÖIR, convelop, KMUFA, ÖAR, ÖGUT sowie Spatial Foresight ging. Die Evaluierung wird in mehreren Leistungspaketen bearbeitet, die sich im Wesentlichen auf die Prioritätsachsen des Programms beziehen, ergänzt um Evaluierungen zu den Bereichen „Governance“, „Kommunikation“ und „Querschnittsthemen“. Die gegenständliche Evaluierung ist ein Bestandteil dieser begleitenden Evaluierung und befasst sich im Kern mit den Maßnahmen der Priorität 1 „Stärkung der regionalen Wettbewerbsfähigkeit durch Forschung, technologische Entwicklung und Innovation“, ergänzt um die Maßnahme 15 „F&I in CO2-Reduktionstechnologien“ (P3) sowie die Maßnahmen 16 „F&T-Infrastruktur (Wien)“ und 17 „Innovationsdienstleistungen (Wien)“ (beide PA4). Mit 226,4 Mio. € decken die behandelten Maßnahmen 42% der EFRE-Mittel des Gesamtprogramms ab. Die Evaluierung zeichnet insgesamt ein überwiegend positives Bild der FTI-Förderung im EFRE, das es gilt, auch in Zukunft aufrechtzuerhalten. Die Empfehlungen der FTI-Evaluierung zielen vor allem auf eine noch klarere Konzeption und Darstellung von FTI-Maßnahmen mit grundsätzlich unterschiedlichen Wirkungslogiken und eine Weiterführung bestehender Bemühungen zur Harmonisierung regional unterschiedlicher Abwicklungsmodi innerhalb dieser Maßnahmen ab. Daneben sollte der Anspruch der Anwendungsorientierung im Lichte der stark wahrgenommenen Grundlagenorientierung in der Praxis reflektiert werden. Auch im Bereich der Datenerfassung und -qualitätsicherung wurden Ansatzpunkte für Verbesserungen aufgezeigt.
Quality of life analysis measured with the Cervantes 16 scale in treated menopausal women with genitourinary syndrome
Authors: Duarte Pablo Romero , Maroto Martín María Teresa , Mar Martín Moya María del , Prados Pedro Abad
Published: November 2022

Aim: To assess the quality of life of menopausal women with genitourinary syndrome receiving local drugs (prasterone, estriol or promestriene).Methods: Prospective, longitudinal, randomized study in which quality of life was assessed using the 16-item Cervantes scale (EC16) before and after treatment.Results: A total of 45 women were assessed (35.6% received prasterone, 33.3% estriol and 31.1% promestriene). After treatment, statistically significant mean score differences were observed in EC16, mainly with prasterone. Improvement in EC16 score only shows a statistically significant relationship with age and drug use.Conclusion: The EC16 is an affordable and quick-to-apply tool that allows physicians and patients to know patients' self-perceived quality of life. Local treatment has been shown to improve the quality of life of menopausal patients with genitourinary syndrome.
Semblanza histórica de las bibliotecas de la Facultad de Estudios Superiores Zaragoza, UNAM
Authors: Hernández Abad Vicente Jesús , Mora Guevara José Luis Alfredo , Escoto Feliciano Palestino , García Escalante Guadalupe Marisol
Published: November 2022

Se presenta un marco retrospectivo de la creación y desarrollo histórico de las bibliotecas de la Facultad de Estudios Superiores Zaragoza UNAM, con visión de innovación en las áreas académicas de las ciencias de la salud, del comportamiento, sociales, químico–biológicas y de las ingenierías, bajo la premisa de transformarse en nodos de concentración de recursos para la enseñanza y el aprendizaje y la finalidad de hacer más eficiente el aprovechamiento de los recursos por parte de la comunidad universitaria, ofreciendo servicios bibliotecarios y de información con recursos impresos y digitales suficientes y actualizados para el apoyo de los planes y programas de estudio, integrando un importante acervo especializado en las áreas académicas mencionadas.
Construction and Validation of the Pregnancy Sleep Disorders Assessment Scale (eetse)
Authors: Pineda-Mújica Iris , Gallardo-Vidal Lilia S. , Ponce-Martínez María del C.
Published: November 2022

Objective: to construct and validate a scale to assess sleep disorders in pregnant women. Method: cross-sectional study, an instrument was constructed in Spanish with questions aimed at investigating sleep disorders that occur during pregnancy. A pilot test was applied to one hundred pregnant women, randomly selected, who attended the Family Medicine Unit no. 8, in El Marqués, Querétaro, from February to May 2021. The questionnaire was submitted to three rounds of expert judges and a reliability analysis was performed to obtain correlation coefficients. Results: a high degree of intelligibility and relevance per question was determined using Delphi methodology. A confirmatory factor analysis was performed for the correlation between variables with the Bartlett’s Test of Sphericity (p<0.001). A feasible degree of intercorrelation between variables was identified, Kaise-Meyer-Olkin = 0.840. The 20 factors of the instrument were distributed in four principal components that yielded the total variance explained. These items presented factor loading >0.30 and communalities >0.35. The item correlation was found between 0.844 and 0.309. Cronbach’s alpha reliability analysis for internal consistency was 0.927. Conclusion: The Pregnancy Sleep Disorders Assessment Scale fulfills the objective of measuring sleep disorders that occur during pregnancy in Mexican women.
Construcción y validación de la Escala de Evaluación de Trastornos del Sueño en Embarazadas (eetse)
Authors: Pineda-Mújica Iris , Gallardo-Vidal Lilia S. , Ponce-Martínez María del C.
Published: November 2022

Objetivo: construir y validar una escala para medir trastornos del sueño en mujeres gestantes. Método: estudio transversal, se construyó un instrumento en español con preguntas dirigidas a investigar los trastornos del sueño que se presentan durante la gestación. Se aplicó una prueba piloto a cien mujeres embarazadas, seleccionadas de forma aleatoria, que acudieron a la Unidad de Medicina Familiar No. 8, en El Marqués, Querétaro, de febrero a mayo de 2021. El cuestionario fue sometido a tres rondas de jueces expertos y se realizó análisis de confiabilidad para obtener los coeficientes de correlación. Resultados: se determinó un alto grado de inteligibilidad y de pertinencia por pregunta mediante la metodología Delphi. Se realizó un análisis factorial confirmatorio para la correlación entre variables con la prueba de esfericidad de Bartlett (p < 0.001). Se identificó un grado factible de intercorrelación entre variables, Kaiser-Meyer-Olkin = 0.840. Los 20 factores del instrumento se distribuyeron en cuatro componentes principales que arrojó la varianza total explicada. Estos ítems presentaron cargas factoriales > 0.30 y comunalidades > 0.35. La correlación ítem - total se encontró entre 0.844 y 0.309. El análisis de confiabilidad alfa de Cronbach para la consistencia interna fue de 0.927. Conclusión: la Escala de Evaluación de Trastornos del Sueño en Embarazadas, cumple con el objetivo de medir los trastornos del sueño que se presentan durante el embarazo en mujeres mexicanas.