bluuebunny/crossref_metadata_2025 huggingface dataset:
[Retracted] Teaching Reform of College Basketball Multimedia Video Image from the Perspective of Basketball Culture
Authors: Zheng Bo , Qu Guangcai
Published: December 2021

Computer‐aided instruction (CAI) is a teaching method that uses modern media to present teaching content, optimize classroom teaching structure, and achieve teaching goals. Multimedia technology integrates graphics, text, and sound, with a large amount of information, rich content, and a good way of human‐computer interaction. This article aims to study the reform of basketball teaching in colleges and universities from the perspective of basketball culture. This article mainly adopts the method of questionnaire survey and uses techniques such as big data statistics to investigate and analyze the composition of basketball teachers in colleges and universities in a certain province; Understand the situation; analyze and understand the impact of basketball culture on the reform of college basketball teaching; analyze the effect of the composition of college basketball teachers on college basketball teaching reform; and investigate the impact of the integration of basketball culture on students’ basketball interest. The results show that about 70% of students believe that basketball can enhance physical fitness and recreation, while most teachers believe that basketball can enhance students ‘physical fitness, impart students’ skills, and promote physical and mental health. The expectations for leisure, entertainment and heritage culture are less than 20%. From the perspective of the age structure of teachers, the basketball team of colleges and universities shows younger characteristics and teachers less than 40 years old account for more than 70% of the total. 81.0% of college basketball teachers are mainly graduates, but the proportion of basketball teachers with a doctorate is significantly lower. Some colleges and universities do not even have a doctorate. Most of them are graduates and undergraduates. Some colleges and universities still have college students. Therefore, teachers often need to have a certain basic knowledge of basketball professional culture, and they should make full use of basketball sports culture and combine them with each other to cultivate their own basketball interests and promote the reform of basketball sports teaching methods in colleges and universities.
The Influence of Research Reports on Stock Returns: The Mediating Effect of Machine-Learning-Based Investor Sentiment
Authors: Shen Xiaohong , Wang Gaoshan , Wang Yue
Published: December 2021

This paper investigates whether and how the research reports issued by securities companies affect stock returns from the perspective of investor sentiment in China. By collecting research reports and investor comments from a popular Chinese investor community, i.e., East Money, we derive two indices that represent the information contained in research reports: one is the attention of research reports and the other is the average stock rating given by research reports; then we develop an investor sentiment indicator using the machine learning method. Based on behavioral finance theory, we hypothesize that research reports have a significant effect on stock returns and investor sentiment plays a mediating role in it. The empirical analysis results confirm the above hypotheses. Specifically, the average stock rating given by research reports can better predict future stock returns, and investor sentiment plays a partial mediating role in the relationship between stock rating and stock returns.
Group Generalized q-Rung Orthopair Fuzzy Soft Sets: New Aggregation Operators and Their Applications
Authors: Hayat Khizar , Shamim Raja Aqib , AlSalman Hussain , Gumaei Abdu , Yang Xiao-Peng , Azeem Akbar Muhammad
Published: December 2021

In recent years, q-rung orthopair fuzzy sets have been appeared to deal with an increase in the value of

q
>
1

, which allows obtaining membership and nonmembership grades from a larger area. Practically, it covers those membership and nonmembership grades, which are not in the range of intuitionistic fuzzy sets. The hybrid form of q-rung orthopair fuzzy sets with soft sets have emerged as a useful framework in fuzzy mathematics and decision-makings. In this paper, we presented group generalized q-rung orthopair fuzzy soft sets (GGq-ROFSSs) by using the combination of q-rung orthopair fuzzy soft sets and q-rung orthopair fuzzy sets. We investigated some basic operations on GGq-ROFSSs. Notably, we initiated new averaging and geometric aggregation operators on GGq-ROFSSs and investigated their underlying properties. A multicriteria decision-making (MCDM) framework is presented and validated through a numerical example. Finally, we showed the interconnection of our methodology with other existing methods.
RNA-Seq Profiling to Investigate the Mechanism of Qishen Granules on Regulating Mitochondrial Energy Metabolism of Heart Failure in Rats
Authors: He Hao , Li Changxiang , Lu Xiangyu , Li Yanqin , Li Xuan , Sun Xiaoqian , Tang Binghua , Wu Yan , Li Chun
Published: December 2021

Background. Qishen granules (QSG) are a frequently prescribed formula with cardioprotective properties prescribed to HF for many years. RNA-seq profiling revealed that regulation on cardiac mitochondrial energy metabolism is the main therapeutic effect. However, the underlying mechanism is still unknown. In this study, we explored the effects of QSG on regulating mitochondrial energy metabolism and oxidative stress through the PGC-1α/NRF1/TFAM signaling pathway. RNA-seq technology revealed that QSG significantly changed the differential gene expression of mitochondrial dysfunction in myocardial ischemic tissue. The mechanism was verified through the left anterior descending artery- (LAD-) induced HF rat model and oxygen glucose deprivation/recovery- (OGD/R-) established H9C2 induction model both in vivo and in vitro. Echocardiography and HE staining showed that QSG could effectively improve the cardiac function of rats with myocardial infarction in functionality and structure. Furthermore, transcriptomics revealed QSG could significantly regulate mitochondrial dysfunction-related proteins at the transcriptome level. The results of electron microscopy and immunofluorescence proved that the mitochondrial morphology, mitochondrial membrane structural integrity, and myocardial oxidative stress damage can be effectively improved after QSG treatment. Mechanism studies showed that QSG increased the expression level of mitochondrial biogenesis factor PGC-1α/NRF1/TFAM protein and regulated the balance of mitochondrial fusion/fission protein expression. QSG could regulate mitochondrial dysfunction in ischemia heart tissue to protect cardiac function and structure in HF rats. The likely mechanism is the adjustment of PGC-1α/NRF1/TFAM pathway to alleviate oxidative stress in myocardial cells. Therefore, PGC-1α may be a potential therapeutic target for improving mitochondrial dysfunction in HF.
Research on the Seam Formation Mechanism of Elliptical Bipolar Linear Directional Blasting Based on the SPH‐FEM Coupling Method
Authors: Wu Bo , Li Hualong , Meng Guowang , Xu Shixiang , Zhang Jinglong , Cui Yaozhong
Published: December 2021

Rock mass blasting is a complex process that involves the coupling of both discontinuous and continuous media. This paper aims to reveal the dynamic failure process between adjacent boreholes under an elliptical bipolar linear charge structure using the SPH‐FEM (smooth particle hydrodynamics and finite‐element method) coupling algorithm numerical simulation method. The numerical simulation results are compared with the existing experimental results, which proves the rationality of the algorithm. According to the numerical simulation results, the shaped jet will first shock the hole wall and form a stress concentration zone that will guide the formation of cracks during the stress wave propagation process. In the case of double‐hole blast loading, there is a tendency for cracks coalescence to develop between adjacent boreholes due to the superposition of stresses between the double holes and the increase in damage and plastic strain. The best blasting results will be achieved with this structure when the distance between adjacent holes is 110 cm. Finally, the superiority of elliptical bipolar linear blasting in engineering blasting was verified through field experiments. The results of this study provide a reference for subsequent applications of elliptical bipolar structures in the field of rock blasting.
Conflict and Sensitivity Analysis of Articulated Vehicle Lateral Stability Based on Single‐Track Model
Authors: Peng Dengzhi , Fang Kekui , Kuang Jianjie , Hassan Mohamed A. , Tan Gangfeng
Published: December 2021

Lateral stability is quite essential for the vehicle. For the vehicle with an articulated steering system, the vehicle load and steering system performance is quite different from the passenger car with the Ackman steering system. To investigate the influence of the tire characteristics and vehicle parameters on lateral stability, a single‐track dynamic model is established based on the vehicle dynamic theory. The accuracy of the built model is validated by the field test result. The investigated parameters include the tire cornering stiffness, vehicle load, wheelbase, and speed. Based on the snaking steering maneuver, the lateral stability criteria including the yaw rate, vehicle sideslip angle, tire sideslip angle, and lateral force are calculated and compared. The sensitivity analysis of the tire and vehicle parameters on the lateral stability indicators is initiated. The results demonstrated that the parameters that aﬀect the lateral vehicle stability the most are the load on the rear part and the tire cornering stiffness. The ﬁndings also lay a foundation for the optimization of the vehicle’s lateral stability.
Comparison of Serum and Dietary Selenium Levels in Participants with a Positive History of Recurrent Herpes Lesions and Healthy Individuals
Authors: Lavaee Fatemeh , Shahrokhi Sardo Maryam , Zarei Fateme , Shahrokhi Sardo Mahla
Published: December 2021

Aim. In this study, we aimed to compare the level of serum and dietary selenium in participants with a positive history of recurrent herpes labial lesions and healthy controls. Materials and Methods. This cross‐sectional study, conducted during 2020‐2021, evaluated the selenium serum level of 40 participants with a positive history of recurrent herpes labial lesions who had referred to Motahhari Laboratory in Shiraz, compared with 38 healthy controls. The selenium level of the serum was assessed by an absorption device, Atomic Graphite Furnace Model FS‐240‐AAS, made by a US Company. Independent T‐test was used to compare the selenium level of males and females. In order to assess the mean age value and gender distribution between the two evaluated groups, the independent T‐test and chi‐square test were used, respectively. The serum selenium level was compered between both control and test groups. Results. The level of serum selenium was not statistically correlated with its dietary level in group 1 (participants with recurrent herpes labialis, P value = 0.18) and group 2 (healthy controls, P value = 0.6). The serum selenium level was compared between groups 1 and 2, which was significantly higher in healthy controls (P value < 0.0001). In contrast, dietary selenium level was not significantly different between patients with a history of herpes labialis and healthy controls (P value = 0.48). The level of serum selenium was not statistically correlated with its dietary level in group 1 (P value = 0.18) and group 2 (P value = 0.6). Conclusion. Patients with recurrent herpes labialis had lower serum selenium level as compared to the healthy controls.
Multisensor Information Fusion‐Assisted Intelligent Art Design under Wireless Virtual Reality Environment
Authors: Wenhao Dong
Published: December 2021

Under the background of intelligent technologies, art designers need to use information technology to assist the design of art factors and fully realize the integration of art design and information technology. Multisensor information fusion technology can more intuitively and visually carry out a more comprehensive grasp of the objectives to be designed, maximize the positive effects of art design, and achieve its overall optimization and can also help art designers get rid of the traditional monolithic and obsolete design concepts. Based on multisensor information fusion technology under wireless virtual reality environment, principles of signal acquisition and preprocessing, feature extraction, and fusion calculation, to analyze the information processing process of multisensor information fusion, conduct the model construction and performance evaluation for intelligent art design, and propose an intelligent art design model based on multisensor information fusion technology, we discuss the realization of multisensor information fusion algorithm in intelligent art design and finally carry out a simulation experiment and its result analysis by taking the environment design of a parent‐child restaurant as an example. The study results show that using multisensor information fusion in the environmental design of parent‐child restaurant is better than using a single sensor for that; at the same time, using force sensors has a better environmental design effect than using vibration sensors. The multisensor information fusion technology can automatically analyze the observation information of several sources obtained in time sequence under certain criteria and comprehensively perform information processing for the completion of the decision‐making and estimation tasks required for intelligent art design.
Application of Passive Wireless RFID Asset Management in Warehousing of Cross‐Border E‐Commerce Enterprises
Authors: Hehua Mao
Published: December 2021

As an important part of modern logistics, warehousing provides a guarantee for the sustainable stability of enterprises, so as to realize the economy of enterprise production and transportation and so as to realize the economy of enterprise production and transportation. With the advent of the information age, the traditional logistics management model has been difficult to adapt to the current increasingly fierce market competition environment. In the management of cross‐border e‐commerce enterprises, warehouse management must establish a systematic and information‐based logistics warehouse management system to improve the level of logistics management. Passive wireless RFID asset management provides a new idea for the construction of warehousing management system of cross‐border e‐commerce enterprises. Through the application of RFID technology, the warehousing design scheme and process of cross‐border e‐commerce enterprises can be optimized and controlled to the greatest extent, so as to strengthen the optimization and integration of supply chain and improve the market competitiveness of logistics enterprises. Based on the wireless passive RFID asset management technology, this paper analyses the construction and optimization of the logistics warehouse management system of cross‐border e‐commerce enterprises. The simulation results show that after the application of wireless passive RFID asset management technology, the warehouse operation efficiency of cross‐border e‐commerce enterprises is improved, the employee utilization rate is relatively reduced, and at the same time, it can also save a lot of manpower and reduce the labour cost.
Computing Simplicial Depth by Using Importance Sampling Algorithm and Its Application
Authors: Meng Fanyu , Shao Wei , Su Yuxia
Published: December 2021

Simplicial depth (SD) plays an important role in discriminant analysis, hypothesis testing, machine learning, and engineering computations. However, the computation of simplicial depth is hugely challenging because the exact algorithm is an NP problem with dimension

d

and sample size

n

as input arguments. The approximate algorithm for simplicial depth computation has extremely low efficiency, especially in high-dimensional cases. In this study, we design an importance sampling algorithm for the computation of simplicial depth. As an advanced Monte Carlo method, the proposed algorithm outperforms other approximate and exact algorithms in accuracy and efficiency, as shown by simulated and real data experiments. Furthermore, we illustrate the robustness of simplicial depth in regression analysis through a concrete physical data experiment.
Fault-Tolerant Secure Routing of
B

H

n

-Based Data Center Networks
Authors: Zhang Xinxin , Xu Li , Li Aihua
Published: December 2021

As the core infrastructure of cloud computing, a large scale of the data center networks (DCNs), which consist of millions of servers with high capacity, suffer from node failure such that the reliability is deteriorated. Malicious group could inevitably compromise the quality and reliability of data; thus, how to ensure the security routing of data is an urgent practical problem. As models for large-scale DCNs, it is worth mentioning the balanced hypercube, which is well-known for its strong connectivity, regularity, and a smaller diameter. Each of which makes a balanced hypercube a trustworthy model to deal with data traffic and provides a certain degree of fault-tolerance as well. In this paper, we use the balanced hypercube as a model for the data center networks and design a reliable safety level by referring to different safety levels of related subgraph. This subgraph contains the source and destination nodes, and the shortest feasible paths are located so that the reliable transmission is achieved. Then, we get that the length of fault-tolerant safety routing of data center networks based on balanced hypercube is always no greater than the Hamming distance plus two. Experiment shows that our fault-tolerant security routing scheme is more effective in the same reliable network environment of DCNs.
Machine Algorithm for Heartbeat Monitoring and Arrhythmia Detection Based on ECG Systems
Authors: Taloba Ahmed I. , Alanazi Rayan , Shahin Osama R. , Elhadad Ahmed , Abozeid Amr , Abd El-Aziz Rasha M.
Published: December 2021

Cardiac arrhythmia is an illness in which a heartbeat is erratic, either too slow or too rapid. It happens as a result of faulty electrical impulses that coordinate the heartbeats. Sudden cardiac death can occur as a result of certain serious arrhythmia disorders. As a result, the primary goal of electrocardiogram (ECG) investigation is to reliably perceive arrhythmias as life‐threatening to provide a suitable therapy and save lives. ECG signals are waveforms that denote the electrical movement of the human heart (P, QRS, and T). The duration, structure, and distances between various peaks of each waveform are utilized to identify heart problems. The signals’ autoregressive (AR) analysis is then used to obtain a specific selection of signal features, the parameters of the AR signal model. Groups of retrieved AR characteristics for three various ECG kinds are cleanly separated in the training dataset, providing high connection classification and heart problem diagnosis to each ECG signal within the training dataset. A new technique based on two‐event‐related moving averages (TERMAs) and fractional Fourier transform (FFT) algorithms is suggested to better evaluate ECG signals. This study could help researchers examine the current state‐of‐the‐art approaches employed in the detection of arrhythmia situations. The characteristic of our suggested machine learning approach is cross‐database training and testing with improved characteristics.
The Discrete Gaussian Expectation Maximization (Gradient) Algorithm for Differential Privacy
Authors: Wu Weisan
Published: December 2021

In this paper, we give a modified gradient EM algorithm; it can protect the privacy of sensitive data by adding discrete Gaussian mechanism noise. Specifically, it makes the high‐dimensional data easier to process mainly by scaling, truncating, noise multiplication, and smoothing steps on the data. Since the variance of discrete Gaussian is smaller than that of the continuous Gaussian, the difference privacy of data can be guaranteed more effectively by adding the noise of the discrete Gaussian mechanism. Finally, the standard gradient EM algorithm, clipped algorithm, and our algorithm (DG‐EM) are compared with the GMM model. The experiments show that our algorithm can effectively protect high‐dimensional sensitive data.
Seismic Performance of Offshore Piers under Wave Impact and Chloride Ion Corrosion Environment
Authors: Gu Yin , Yu Anhua , Zhang Xiaolong
Published: December 2021

Offshore bridges may suffer from chloride ion corrosion, tsunami wave impact, and earthquake. However, the coupling effects of multiple factors have not been fully considered. This paper studied multiple degradation effects on the seismic performance of offshore piers considering tsunami wave impact, chloride ion corrosion, and their interaction. Firstly, through the scale model test of tsunami wave flume, the wave force of box girder structures and piers under different tsunami wave conditions is measured. Then, according to the corrosion characteristics of coastal chloride salts on reinforced concrete bridge piers, the corrosion parameters is selected by Latin hypercube sampling, and the influence of corrosion expansion and cracking of bridge pier cover on the chloride ion corrosion process is considered to modify the degradation model of corroded reinforced concrete materials. Finally, the wave load measured by the test is converted by the similarity criterion of the fluid mechanic test and loaded into the ABAQUS full‐bridge model, and the pier after the tsunami wave is evaluated by the pushover analysis. The bearing capacity and lateral stiffness of the corroded pier before and after different tsunami waves are compared. The results show that the lateral bearing capacity and stiffness of bridge piers are, respectively, decreased by 27.6% and 6.2% after 30 years of service. Without corrosion, the lateral bearing capacity and stiffness of piers were, respectively, reduced by 11.45% and 10.6% after HXB‐5 wave impact. After 30 years of service, the lateral bearing capacity and stiffness of bridge piers are, respectively, reduced by 41.8% and 22.5% under the combined action of corrosion and HXB‐5 wave impact. It is found that the coupling effects of multiple degradation factors were more significant than the simple superposition ones. Therefore, the coupling effect of multiple factors should be considered in practical engineering.
Algorithm of 3D Virtual Reconstruction of Ancient Buildings in Qing Dynasty Based on Image Sequence
Authors: Lu Chuan
Published: December 2021

Aiming at the problem of low accuracy and poor integrity of traditional Qing Dynasty ancient architecture 3D virtual reconstruction algorithm, a 3D virtual reconstruction algorithm of Qing Dynasty ancient architecture based on image sequence is proposed. Acquire the sequence images of ancient buildings in the Qing Dynasty through the pinhole camera model, analyze the projective space and reconstruction space of the sequence images, redefine the similarity measurement coefficient according to the improved 2DPCA-SIFT feature matching algorithm, match the feature points of the ancient architecture images in the Qing Dynasty, and use random sampling to be consistent. The algorithm solves the basic matrix, removes the interference error in the image reconstruction process, and realizes the design of the three-dimensional reconstruction algorithm through image sequence fusion. The experimental results show that, compared with the existing methods, the completeness of the three-dimensional virtual reconstruction 3D model of ancient Qing Dynasty buildings constructed by the designed algorithm is 87.26% on average, and the completeness and accuracy of the 3D model construction of the subparts of the ancient Qing Dynasty buildings of this method are better. The height of the building fully shows that the designed building has good performance in the construction of the three-dimensional model of ancient buildings in the Qing Dynasty.
Cognitive Impairment in Genetic Parkinson’s Disease
Authors: Planas-Ballvé A. , Vilas D.
Published: December 2021

Cognitive impairment is common in idiopathic Parkinson’s disease (PD). Knowledge of the contribution of genetics to cognition in PD is increasing in the last decades. Monogenic forms of genetic PD show distinct cognitive profiles and rate of cognitive decline progression. Cognitive impairment is higher in GBA- and SNCA-associated PD, lower in Parkin- and PINK1-PD, and possibly milder in LRRK2-PD. In this review, we summarize data regarding cognitive function on clinical studies, neuroimaging, and biological markers of cognitive decline in autosomal dominant PD linked to mutations in LRRK2 and SNCA, autosomal recessive PD linked to Parkin and PINK1, and also PD linked to GBA mutations.
Knockdown of lncRNA CCAT1 Inhibits the Progression of Colorectal Cancer via hsa-miR-4679 Mediating the Downregulation of GNG10
Authors: Wang Ning , Li Jun , He Ju , Jing Yong-Guang , Zhao Wei-dong , Yu Wen-jin , Wang Jing
Published: December 2021

Great concerns have raised crucial roles of long noncoding RNAs (lncRNAs) on colorectal cancer progression due to the increasing number of studies in cancer development. Previous studies reveal that lncRNA CCAT1 plays an important role in the progression of a variety of cancers. However, the role of lncRNA CCAT1 in colorectal cancer is still unclear. In this study, we found that in both colorectal tissues and cell lines the level of lncRNA CCAT1 was increased. Downregulation of lncRNA CCAT1 inhibited the proliferation, migration, and invasion of colorectal cell lines and promoted apoptosis. We then found that hsa-miR-4679 could bind to lncRNA CCAT1 directly, and with further functional analyses, we confirmed that lncRNA CCAT1 sponged hsa-miR-4679 to promote the progression of colorectal cancer. Next, we found that hsa-miR-4679 was directly bound to 3

′

UTR of GNG10 (guanine nucleotide-binding protein, gamma 10). GNG10 overexpression promoted the progression of colorectal cancer, and this phenotype could be reversed by miR-4679 mimics. At last, we knocked down CCAT1 in vivo and found that sh-CCAT1 reduced the tumor size and the number of proliferating cells. In summary, our findings revealed that lncRNA CCAT1 facilitated colorectal cancer progression via the hsa-miR-4679/GNG10 axis and provided new potential therapeutic targets for colorectal cancer.
Location-Routing Problem of Emergency Facilities under Uncertain Demand by Branch-Price and Cut
Authors: Deng Xuchen
Published: December 2021

This paper studies the location-routing problem of emergency facilities with time window under demand uncertainty. We propose a robust mathematical model in which uncertain requirements are represented by two forms: the support set defined by cardinal constraint set. When the demand value of rescue point changes in a given definition set, the model can ensure the feasibility of each line. We propose a branch and price cutting algorithm, whose pricing problem is a robust resource-constrained shortest path problem. In addition, we take the Wenchuan Earthquake as an example to verify the practicability of the method. The robust model is simulated under different uncertainty levels and distributions and compared with the scheme obtained by the deterministic problem. The results show that the robust model can run successfully and maintain its robustness, and the robust model provides better protection against demand uncertainty. In addition, we find that cost is more sensitive to uncertainty level than protection level, and our proposed model also allows controlling the robustness level of the solution by adjusting the protection level. In all experiments, the cost of robustness is that the routing cost increases by an average of 13.87%.
lncRNA PCAT14 Is a Diagnostic Marker for Prostate Cancer and Is Associated with Immune Cell Infiltration
Authors: Yan Yunkun , Liu Jianjun , Xu Zhijian , Ye Mushi , Li Jianchang
Published: December 2021

Objective. To investigate the relationship between the long noncoding RNA (lncRNA) Prostate cancer-associated transcription factors 14 (PCAT14) and the clinical characteristics of prostate cancer and immune cell infiltration. Methods. The relationship between PCAT14 expression and the clinicopathological characteristics of prostate cancer was analyzed based on The Cancer Genome Atlas (TCGA) database. Receiver operating characteristic (ROC) curves were used to evaluate the value of PCAT14 as a diagnostic marker for prostate cancer. The relationship between PCAT14 and immune cell infiltration was analyzed to explore the effect of PCAT14 on the immune-related functions of prostate cancer. Results. The ROC curve showed that PCAT14 had a significant diagnostic ability (

area
 
under
 
curve
=
0.818

) for prostate cancer. A reduced expression of PCAT14 in prostate cancer was related to T stage, N stage, primary therapy outcome, residual tumor, Gleason score, and age. The expression of PCAT14 was independently associated with the progression-free interval in prostate cancer patients. The infiltration of immune cells in prostate cancer showed a significant negative correlation between the expression of PCAT14 and plasmacytoid dendritic cells, activated dendritic cells, regulatory T cells, and neutrophils. Conclusions. PCAT14 is highly expressed in prostate cancer and is expected to be a diagnostic marker. PCAT14 might promote the development of prostate cancer through chemokines, antimicrobials, and cytokines that affect the infiltration of immune cells.
Optimisation of Driver’s Traffic Literacy Evaluation Index from the Perspective of Information Contribution Sensitivity
Authors: Wang Lingzhi , Tian Kang
Published: December 2021

The practice has proven that relying solely on large-scale transportation facilities cannot fundamentally alleviate urban transportation problems. Since the motor vehicle drivers are the main participants of transportation, they should improve their knowledge of transportation. Moreover, the drivers should equally cope with transportation problems. This paper establishes an evaluation index system for traffic literacy of urban drivers. In addition, it proposes a method of information contribution sensitivity to optimise the index system. The main results and achievement of this paper include the following: (1) A traffic literacy evaluation index system including 13 evaluation indexes such as traffic rules and general knowledge of machinery has been constructed. (2) Based on the calculation results of the sensitivity of the information contribution, the first 10 indexes that satisfy the cumulative information contribution rate’s value of greater than 90% are retained and 3 indexes with lower contribution rates are eliminated. This study provides a theoretical framework and basic methods to evaluate the traffic literacy of urban drivers.
Trading and Pricing Sensor Data in Competing Edge Servers with Double Auction Markets
Authors: Shi Bing , Song Zhaoxiang , Xu Jianqiao
Published: December 2021

With the development of the IoT (Internet of Things), sensors networks can bring a large amount of valuable data. In addition to be utilized in the local IoT applications, the data can also be traded in the connected edge servers. As an efficient resource allocation mechanism, the double auction has been widely used in the stock and futures markets and can be also applied in the data resource allocation in sensor networks. Currently, there usually exist multiple edge servers running double auctions competing with each other to attract data users (buyers) and producers (sellers). Therefore, the double auction market run on each edge server needs efficient mechanism to improve the allocation efficiency. Specifically, the pricing strategy of the double auction plays an important role on affecting traders’ profit, and thus, will affect the traders’ market choices and bidding strategies, which in turn affect the competition result of double auction markets. In addition, the traders’ trading strategies will also affect the market’s pricing strategy. Therefore, we need to analyze the double auction markets’ pricing strategy and traders’ trading strategies. Specifically, we use a deep reinforcement learning algorithm combined with mean field theory to solve this problem with a huge state and action space. For trading strategies, we use the Independent Parametrized Deep Q‐Network (I‐PDQN) algorithm combined with mean field theory to compute the Nash equilibrium strategies. We then compare it with the fictitious play (FP) algorithm. The experimental results show that the computation speed of I‐PDQN algorithm is significantly faster than that of FP algorithm. For pricing strategies, the double auction markets will dynamically adjust the pricing strategy according to traders’ trading strategies. This is a sequential decision‐making process involving multiple agents. Therefore, we model it as a Markov game. We adopt Multiagent Deep Deterministic Policy Gradient (MADDPG) algorithm to analyze the Nash equilibrium pricing strategies. The experimental results show that the MADDPG algorithm solves the problem faster than the FP algorithm.
Elevated P-Element-Induced Wimpy-Testis-Like Protein 1 Expression Predicts Unfavorable Prognosis for Patients with Various Cancers
Authors: Jiang Kehua , Ye Tao , Du Juan , Tang Lanlan , Chen Xiaolong , Sun Fa , Sun Xifeng
Published: December 2021

Increasing evidence has shown that overexpression of P-element-induced wimpy-testis (PIWI)-like protein 1 (PIWIL1) was associated with unfavorable prognosis of patients with various types of cancers. Herein, we conducted this meta-analysis to identify the clinicopathological and prognostic value of the PIWIL1 expression in cancers. Three electronic databases (PubMed, Web of Science, and Embase) were comprehensively retrieved for relevant studies up to August 4th, 2019. RevMan 5.3 and STATA 12.0 statistical software programs were used to explore the relationships between PIWIL1 expression and the prognosis and clinicopathological features in cancer patients. A total of 13 studies recruiting 2179 patients with 9 types of solid tumors were finally included in the meta-analysis. The results indicated that patients with high PIWIL1 expression tended to have a shorter survival, and additionally deeper tumor invasion, higher clinical stage, and more lymph node metastasis. PIWIL1 could serve as a biomarker for prognosis and clinicopathological characteristics in various cancers.
Burnout y bienestar estudiantil: una mirada nueva a un problema viejo
Authors: Bitran Marcela
Published: December 2021

El aumento de la prevalencia de problemas de salud mental y burnout en estudiantes y profesionales de la salud en Chile y el mundo, asociado a la actual pandemia de COVID-19, ha visibilizado un viejo problema que urge abordar:  el agotamiento crónico y los problemas de salud mental que sufren los estudiantes a lo largo de su formación.  Para resolverlo, se requiere mucho más que mejorar el acceso a servicios de salud mental o propiciar iniciativas puntuales que promuevan el bienestar. Es preciso revisar la cultura institucional, remover las barreras al bienestar e introducir iniciativas que permitan la ‘seguridad psicológica’, característica de ambientes educacionales que favorecen el bienestar y el aprendizaje significativo. En un futuro cercano, las instituciones formadoras tendrán que demostrar que sus estudiantes y docentes tienen niveles adecuados de bienestar, y que implementan y evalúan regularmente el impacto de las políticas curriculares destinadas a asegurar este objetivo. En este artículo revisaremos la situación de salud mental de los estudiantes de medicina, particularmente del síndrome de agotamiento profesional o burnout y sus consecuencias; describiremos algunas evidencias de intervenciones exitosas para reducir el burnout, incluyendo una experiencia nacional, y analizaremos la relación entre la cultura médica y el bienestar estudiantil. Finalmente, reflexionaremos sobre las características de los ambientes educacionales que permiten un aprendizaje profundo y significativo, y que compatibilizan la excelencia académica con el bienestar de los aprendices.
Adaptación de una metodología de especificaciones en la calificación y retroalimentación en la enseñanza de cursos de ciencias básicas en una carrera de la salud para mejorar los aprendizajes y la motivación
Authors: Cerda Mauricio , Gormaz Karen , Vega Héctor , Castañeda Víctor , Varela Diego , Casas Mariana , Dunstan Jocelyn , De la Fuente Milton , Kunakov Natasha
Published: December 2021

Introducción: la enseñanza de cursos de ciencias básicas en carreras de la salud es un desafío por no estar directa e inmediatamente relacionada con el ámbito profesional. Por otra parte, las condiciones de estrés que ha impuesto el trabajo a distancia requiere de metodologías motivantes, y, que a su vez permitan una evaluación significativa. Objetivos: reportar las adaptaciones metodológicas y los resultados de una adaptación local de la metodología de especificaciones de las calificaciones y retroalimentación del trabajo. Métodos: se aplica una metodología de formación basada en la retroalimentación en el curso de Física para estudiantes de Tecnología Médica (N=106) durante un semestre. Las calificaciones promedio de los estudiantes fueron comparadas con las obtenidas en años anteriores. Para evaluar el desempeño docente se realizaron 2 encuestas a los estudiantes. El cumplimiento de los logros de aprendizaje se midió mediante auto-evaluación (escala likert 1 a 5) al inicio y término de cada uno de los cuatro capítulos. Resultados: las reprobaciones y eliminaciones de estudiantes en el curso fueron menores a años anteriores, siendo las notas significativamente mayores subiendo desde 4,89 a 6,29 (escala de 1 a 7, p<0,001). Los estudiantes se mostraron en un 95% satisfechos con el desempeño docente y finalmente, la auto-evaluación de logros de aprendizaje mostró un aumento promedio de 1 punto. Conclusiones: la metodología de evaluación basada en especificaciones adaptada a dos entregas y con evaluaciones en una escala no-binaria mejoró el rendimiento, los logros de los aprendizajes esperados y la motivación de los estudiantes.
Acute Coronary Syndromes in Sub‐Saharan Africa: A 10‐Year Systematic Review
Authors: Yao Hermann , Ekou Arnaud , Niamkey Thierry , Hounhoui Gan Sandra , Kouamé Isabelle , Afassinou Yaovi , Ehouman Esther , Touré Camille , Zeller Marianne , Cottin Yves , N’Guetta Roland
Published: December 2021

Background

Data in the literature on acute coronary syndrome in sub‐Saharan Africa are scarce.

Methods and Results

We conducted a systematic review of the MEDLINE (PubMed) database of observational studies of acute coronary syndrome in sub‐Saharan Africa from January 1, 2010 to June 30, 2020. Acute coronary syndrome was defined according to current definitions. Abstracts and then the full texts of the selected articles were independently screened by 2 blinded investigators. This systematic review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta‐Analyses standards. We identified 784 articles with our research strategy, and 27 were taken into account for the final analysis. Ten studies report a prevalence of acute coronary syndrome among patients admitted for cardiovascular disease ranging from 0.21% to 22.3%. Patients were younger, with a minimum age of 52 years in South Africa and Djibouti. There was a significant male predominance. Hypertension was the main risk factor (50%–55% of cases). Time to admission tended to be long, with the longest times in Tanzania (6.6 days) and Burkina Faso (4.3 days). Very few patients were admitted by medicalized transport, particularly in Côte d'Ivoire (only 34% including 8% by emergency medical service). The clinical presentation is dominated by ST–elevation sudden cardiac arrest. Percutaneous coronary intervention is not widely available but was performed in South Africa, Kenya, Côte d'Ivoire, Sudan, and Mauritania. Fibrinolysis was the most accessible means of revascularization, with streptokinase as the molecule of choice. Hospital mortality was highly variable between 1.2% and 24.5% depending on the study populations and the revascularization procedures performed. Mortality at follow‐up varied from 7.8% to 43.3%. Some studies identified factors predictive of mortality.

Conclusions

The significant disparities in our results underscore the need for a multicenter registry for acute coronary syndrome in sub‐Saharan Africa in order to develop consensus‐based strategies, propose and evaluate tailored interventions, and identify prognostic factors.
Combined Effect of Homocysteine and Uric Acid to Identify Patients With High Risk for Subclinical Atrial Fibrillation
Authors: Wang Shihao , Wei Yushan , Hidru Tesfaldet Habtemariam , Li Daobo , Wang Nan , Yang Yiheng , Wang Yunsong , Yang Xiaolei , Xia Yunlong
Published: December 2021

Background

Subclinical atrial fibrillation (SCAF) is often asymptomatic nonetheless harmful. In patients with cardiac implantable electronic devices, we evaluated the combined performance of homocysteine and uric acid (UA) biomarkers to discriminate high‐risk patients for SCAF.

Methods and Results

We enrolled 1224 consecutive patients for evaluation of SCAF in patients with cardiac implantable electronic devices in Dalian, China, between January 2013 and December 2019. Clinical data and blood samples were obtained from patients selected according to the absence or presence of atrial high‐rate episodes >6 minutes. Blood samples were obtained, and homocysteine and UA biomarkers were tested in all patients to distinguish their prognostic performance for SCAF. Homocysteine and UA biomarkers were significantly different in SCAF versus no SCAF. On multivariable Cox regression analysis with potential confounders, elevated homocysteine and UA biomarkers were significantly associated with an increased risk of SCAF. A rise of 1 SD in homocysteine (5.7 μmol/L) was associated with an increased risk of SCAF in men and women regardless of their UA levels. Similarly, a 1‐SD increase in UA (91 μmol/L) was associated with an increased risk of SCAF among the patients with high levels of homocysteine in men (hazard ratio, 1.81; 95% CI, 1.43–2.30) and women (hazard ratio, 2.11; 95% CI, 1.69–2.62). The addition of homocysteine and UA to the atrial fibrillation risk factors recommended by the 2020 European Society of Cardiology Guidelines significantly improved risk discrimination for SCAF.

Conclusions

Homocysteine and UA biomarkers were strongly associated with SCAF. The prediction performance of the European Society of Cardiology model for SCAF was increased by the addition of the selected biomarkers.

Registration

URL:
https://www.chictr.org.cn
; Unique identifier: Chi‐CTR200003837.
Serum Growth Differentiation Factor 15 Levels Are Associated With Depression After Ischemic Stroke
Authors: Zang Yuhan , Zhu Zhengbao , Xie Yi , Liu Zhen , Yin Jieyun , Yang Pinni , Zhang Kaixin , Bu Xiaoqing , Wang Aili , Chen Jing , Zhang Yonghong , He Jiang
Published: December 2021

Background

The effect of serum growth differentiation factor 15 (GDF‐15) on poststroke depression (PSD) remains unknown. This study aimed to investigate the association between serum GDF‐15 and PSD among patients with ischemic stroke.

Methods and Results

This study was based on a random sample from CATIS (China Antihypertensive Trial in Acute Ischemic Stroke). A total of 572 patients from 7 participating hospitals with GDF‐15 levels were included in this analysis. The study outcome was depression (Hamilton Depression Rating Scale score ≥8) at 3 months after ischemic stroke. A total of 231 (40.4%) patients with stroke experienced PSD within 3 months. The multivariate‐adjusted odds ratio of PSD associated with the highest tertile of serum GDF‐15 was 2.92 (95% CI, 1.36–6.27) compared with the lowest tertile. Each SD increase in log‐transformed GDF‐15 was associated with a 42% (95% CI, 2%–97%) increased risk of PSD, and a linear association between serum GDF‐15 and the risk of PSD was observed (
P
for linearity=0.006).

Conclusions

Elevated serum GDF‐15 levels in the acute phase of ischemic stroke were independently associated with PSD, suggesting that GDF‐15 may be a valuable prognostic biomarker for PSD.
Use of Direct Oral Anticoagulant and Outcomes in Patients With Atrial Fibrillation after Transcatheter Aortic Valve Replacement: Insights From the STS/ACC TVT Registry
Authors: Tanawuttiwat Tanyanan , Stebbins Amanda , Marquis‐Gravel Guillaume , Vemulapalli Sreekanth , Kosinski Andrzej S. , Cheng Alan
Published: December 2021

Background

Clinical evidence on the safety and effectiveness of using direct oral anticoagulants (DOACs) in patients with atrial fibrillation after transcatheter aortic valve replacement (TAVR) remains limited. The aim of this study was to investigate the trends and outcomes of using DOACs in patients with TAVR and atrial fibrillation.

Methods and Results

Data from the STS/ACC TVT (Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy) Registry was used to identify patients who underwent successful TAVR with preexisting or incident atrial fibrillation who were discharged on oral anticoagulation between January 2013 and May 2018. Patients with a mechanical valve, valve‐in‐valve procedure, or prior stroke within a year were excluded. The adjusted primary outcome was 1‐year stroke events. The adjusted secondary outcomes included bleeding, intracranial hemorrhage, and death. A total of 21 131 patients were included in the study (13 004 TAVR patients were discharged on a vitamin K antagonist and 8127 were discharged on DOACs.) The use of DOACs increased 5.5‐fold from 2013 to 2018. The 1‐year incidence of stroke was comparable between DOAC‐treated patients and vitamin K antagonist‐treated patients (2.51% versus 2.37%; hazard ratio [HR], 1.00; 95% CI, 0.81–1.23) whereas DOAC‐treated patients had lower 1‐year incidence of any bleeding (11.9% versus 15.0%; HR, 0.81; 95% CI, 0.75–0.89), intracranial hemorrhage (0.33% versus 0.59%; HR, 0.54; 95% CI, 0.33–0.87), and death (15.8% versus 18.2%; HR, 0.92; 95% CI, 0.85–1.00).

Conclusions

In patients with TAVR and atrial fibrillation, DOAC use, when compared with vitamin K antagonists, was associated with comparable stroke risk and significantly lower risks of bleeding, intracranial hemorrhage, and death at 1 year.