bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of the efficacy and safety of injectable glycosaminoglycan-peptide complex (GPC) in patients with osteoarthritis: a multicenter observational study GLADIOLUS (GPC in the treatment of osteoarthritis: a follow-up study of pain relief and local symptom reduction)
Authors: Alekseeva L. I. , Karateev A. E. , Pogozheva E. Yu. , Amirdzanova V. N. , Filatova E. S. , Nesterenko V. A.
Published: May 2020

Glycosaminoglycan-peptide complex (GPC) is a popular injectable extended-release symptomatic agent (ERSA) in Russia for the treatment of osteoarthritis (OA). To date, no large-scale studies of GPC used in real clinical practice have been conducted in our country.Objective: to evaluate the efficacy and safety of GPC in the treatment of OA in real clinical practice.Patients and methods. A multicenter observational non-interventional study was performed to evaluate the efficacy of GPC (Rumalon® , a cycle of intramuscular injections thrice weekly; a total of 25 injections). A study group consisted of 2,955 patients (75.4% female) aged 61.4±11.8 years) with knee and hip OA, and generalized OA (GOA) with the previous inefficacy of oral ERSAs, moderate/severe pain, and the need for regular use of nonsteroidal anti-inflammatory drugs (NSAIDs). 414 (14%) patients received a GPC and diacerein combination 100 mg/day. The investigators assessed the dynamics of pain during movement and at rest, functional disorders (on a numeric rating scale (NRS) of 0–10), as well as the need for NSAIDs at 12 weeks after starting the GPC cycle.Results and discussion. 98.5% of the patients completed their GPC treatment cycle. The therapy decreased the intensity of pain at rest from 4 [3; 5] to 1 [0; 2] and during movement from 6 [5; 7] to 2 [1; 3] and reduced the severity of functional disorders from 5 [4; 6] to 1 [0; 3]. The number of patients with a good response to therapy (a≥50% decrease in symptom severity) for pain at rest and during movement was 55.6 and 53.5%, respectively; and for functional disorders was 50.8%. 68.1% of patients stopped taking NSAIDs. The GPC and diacerein combination was more effective than GPC monotherapy: the number of patients with a ≥50% decrease in movement pain was 62.8 and 54.3%, respectively (p <0.001). GPC was well tolerated. During treatment, there were skin allergic reactions (0.3%), moderate injection-site pain (0.37%), and adverse reactions (ARs) related to the gastrointestinal tract (8%) and cardiovascular system (6%) (which were likely to be caused by NSAIDs). There were no serious ARs that were life-threatening and required hospitalization.Conclusion. GPC allows successful control of the main symptoms of knee and hip OA and GOA, by reducing pain, and those of functional disorders, and the need for NSAIDs. The GPC and diacerein combination is more effective than GPC monotherapy. GPC therapy is well tolerated and very rarely causes ARs.
Osteoporosis and sarcopenia in women with rheumatoid arthritis
Authors: Dobrovolskaya O. V. , Feklistov A. Yu. , Efremova A. O. , Toroptsova N. V. , Nikitinskaya O. A. , Demin N. V.
Published: May 2020

Objective: to assess bone mineral density (BMD) and the incidence of osteoporosis (OP) and sarcopenia (SP) in women suffering from rheumatoid arthritis (RA).Patients and methods. Eighty-one women (mean age, 59.0±8.1 years) with a reliable diagnosis of RA were examined. The women underwent the following studies: a survey using a special questionnaire; tests to measure the functional status of muscles, including those to determine their strength; as well as dual-energy X-ray absorptiometry of the axial skeleton and whole body.Results and discussion. According to the EWGSOP2 criteria, 20 (24.7%) female patients were diagnosed with SP, 24 (29.6%) had OP, and 39 (48.2%) had osteopenia. OP in female patients with and without SP occurred in 35.0 and 27.9% of cases, respectively (p>0.05). BMD in the femoral neck and in the proximal femur as a whole was significantly lower in the presence of SP than in its absence (p=0.0006 and p=0.0061, respectively). The frequency of falls was significantly higher in the female patients with SP than in those without SP (p=0.028). The major osteoporotic and hip fracture probabilities calculated according to the FRAX ® algorithm was higher in the patients with SP than in those without SP (p=0.041 and p=0.033, respectively). There were positive correlations of BMD with body mass index, appendicular muscle mass, appendicular muscle index, hand strength, shoulder circumference, and the serum levels of calcium, creatinine and uric acid, as well as negative correlations with age, postmenopausal length, and RA duration.Conclusion. OP and SP are common RA complications that increase the risk of falls and fractures.
«I am getting better» and «I feel good»: searching for an objective criterion for a clinical response to analgesic therapy for rheumatic diseases
Authors: Karateev A. E. , Pogozheva E. Yu. , Amirdzanova V. N. , Filatova E. S. , Nesterenko V. A.
Published: May 2020

Analysis of the results of clinical trials should be based on the use of objective parameters that allow for assessing the significance of the data obtained for real medical practice. These parameters include Minimal Clinically Important Improvement (MCII) and Patient Acceptable Symptom State (PASS).Objective: to determine the approximate value of the parameters MCII and PASS on the basis of data from the PARACELS (Regular Piascledine and Artrosilene Administration for osteoarthritis (OA): Expediency of the Unified Treatment Regimen) study.Patients and methods. A study group consisted of 6,448 patients (70.9% female, 29.1% male) (mean age, 57.8±10.2 years) with knee OA and moderate or severe pain of ≥40 mm on a 100-mm visual analogue scale (VAS). All the patients took during 12 weeks avocado/soybean unsaponifiables 300 mg/day and a nonsteroidal anti-inflammatory drug (ketoprofen lysine salt) 320 mg/day, which was prescribed at the beginning of treatment for 10–14 days and then could be used on demand with more pain to come. Pain intensity was measured using the 100-mm VAS. Patient satisfaction with treatment results was also studied with a point scale, where 0 is worsening or no effect, while 5 is an excellent effect. The dynamics of pain was compared and treatment results were assessed by patients.Results and discussion. After 12 weeks, most patients showed a substantial improvement: a mean pain intensity reduction of 77.7±29.6%. A satisfactory treatment result estimate (that can be considered as a surrogate measure of MCII) corresponded to an average pain reduction of 32.0±11.7 mm on VAS (a 47.3% improvement compared to the baseline level). A good treatment result estimate (that can be considered as a surrogate measure of PASS) corresponded to an average pain reduction of 41.0±13.3 mm on VAS (a 62.9% improvement compared to the baseline level).Conclusion. The PARACELS study has shown that in Russian patients receiving analgesic therapy, MCII can correspond to a pain reduction of >30 mm on VAS (>40% of the baseline level), PASS can do to its reduction of >40 mm on VAS (>60% of the baseline level).
Practical application of national clinical guidelines for the management of gout (preliminary data)
Authors: Chikina M. N. , Eliseev M. S. , Zhelyabina O. V.
Published: May 2020

The 2018 national guidelines for the management of gout provide a consistent scheme for urate-lowering drugs; however, the possibility of achieving uric acid (UA) targets in its use has not been studied.Objective: to evaluate the effectiveness and safety of the urate-lowering therapy algorithm presented in the national guidelines for the management of gout.Patients and methods. This investigation was a prospective single-center study. It has been currently included 54 patients (91% males) with gout. The follow-up period is not less than 12 weeks of continuous use of allopurinol or febuxostat (Azurix) at the final dose.After the initiation of urate-lowering therapy, allopurinol 100 mg/day was prescribed, followed by dose titration to achieve the UA target that was defined as <360 or <300 μmol/L in patients with severe tophaceous gout. The maximum dose was 900 mg/day; it was 300 mg/day when the glomerular filtration rate was <60 ml/min/1.73 m2 . Patients with the inefficacy of allopurinol and/or the presence of its associated adverse reactions (ARs) were prescribed febuxostat 80 mg/day; the dose was increased to 120 mg/day as needed.For the prevention of acute arthritis attacks, all the patients received a nonsteroidal anti-inflammatory drug (NSAID) at the minimum therapeutic doses or colchicine 0.5 mg/day, and if these drugs were contraindicated, a glucocorticoid (GC) 7.5 mg/day, as calculated with reference to prednisone, was taken.The probability of achieving the serum UA target (<360 or 300 μmol/L) was assessed in patients with chronic tophaceous gout.Results and discussion. 12 weeks after therapy initiation, the UA target could be achieved in 39/50 (79%) patients. The target levels <360 and 360 μmol/L were recorded in 15/21 (71%) and 24/33 (73%), respectively. The UA level <360 μmol/L was noted to decrease in a total of 92% of cases. Febuxostat was given to 41 patients: to 27 (66%) due to the inefficacy of allopurinol and to 14 (34%) due to its ARs. As a result, the UA target was achieved in 30 (73%) patients, and there was a decrease in the UA level <360 μmol/L in 35 (85%).ARs were seen only in 3 febuxostat-treated patients, including 2 patients with previous allopurinol-induced ARs.For the prevention of arthritis attacks, 10 (19%) patients took NSAIDs, 41 (75%) received colchicine, and 3 (6%) used GC. There were no refusals to receive urate-lowering and preventive anti-inflammatory therapies.Conclusion. The proposed treatment regimen allows for achieving the serum UA target in 79% of patients and its decrease <360 μmol/L in 92%. Treatment with febuxostat (Azurix) is associated with its good tolerance, including in the patients who could not use allopurinol because of AR. Preventive anti-inflammatory therapy is likely to improve adherence to urate-lowering therapy.
Pemberdayaan Muslim Muallaf Melalui Home Industry Kerupuk Ikan Lomek di Desa Selat Akar
Authors: Masduki Masduki , Hartono Toni , Sardila Vera , Arung Triantoro Dony
Published: May 2020

This article discusses about economic empowerment based on home industry to enforce the faith of new Muslim converters in Desa Selat Akar Kepualaun Meranti, Riau. To understand the economic potential of this village, the faith enforcement seems to be more effective when it is done through economic empowerment based on home industry. This resesearch was founded, i.e. To support this, the empowerment uses community based research concept. This research founded i.e. first, doing an evaluation during observation and conducting identification before the empowerment done. Second, this empowerment finds that this a new Muslim group needs physical capital assistance to develop its enterprises. Third, making ‘Lomek’ fish crackers has become an instrument or media among the Muallafs to keep and improve their faith. Tulisan ini mendiskusikan pemberdayaan ekonomi berbasis home industry untuk penguatan akidah Muslim Muallaf di Desa Selat Akar Kepulauan Meranti, Riau. Memahami potensi ekonomi yang ada di desa tersebut, maka penguatan akidah para Muslim Muallaf tampak menjadi lebih efektif apabila dilakukan dengan penguatan sisi ekonomi rumahan atau berbasis home industry. Untuk mendukung keberhasilan kegiatan, pemberdayaan ini menggunakan konsep Community Based Research (CBR) dengan metode kualitatif. Penelitian ini menemukan beberapa program pemberdayaan antara lain; pertama, melakukan evaluasi pada saat observasi dan identifikasi sebelum pemberdayaan dilakukan. Kedua, menemukan bahwa kelompok Muslim Muallaf memerlukan bantuan modal fisik untuk pengembangan usaha mereka. Ketiga, membuat kerupuk Ikan Lomek benar-benar telah menjadi media sekaligus wadah tempat di mana para Muslim Muallaf dapat meningkatkan dan memperkokoh akidah mereka.
Struktur Logika Teologi Islam Menurut Van Ess: Sebuah Telaah Kritis
Authors: Arif Muhammad
Published: May 2020

Josef van Ess melalui tulisannya “The Logical Structure of Islamic Theology” menyatakan bahwa logika teologi Islam telah banyak mengadopsi logika Yunani kuno, terutama logika Stoic. Menurut penelusuran van Ess, ada banyak kesamaan mencolok antara konsep-konsep dan istilah- istilah yang digunakan dalam teologi Islam dengan logika Stoic. Tidak ayal, van Ess kemudian berkesimpulan bahwa struktur logika teologi Islam sejatinya tidak lain hanyalah derevasi dari bangunan logika Stoic. Pendapat van Ess ini tentu sangat menarik untuk dikaji. Bukankah sejarah mencatat bahwa gaya teologi Islam sejatinya telah dimulai sejak masa Nabi, jauh sebelum Islam bersentuhan dengan tradisi Yunani? Selain itu, apakah dengan mengadopsi konsep dan istilah logika Stoic, lantas bisa dikatakan  bahwa struktur logika teologi Islam adalah derevatif? Bukankah konsep dan istilah itu telah digunakan dalam kultur dan konsteks yang sama sekali berbeda? Semua persoalan ini diulas secara sederhana dalam artikel ini.
Pengaruh Kekuasaan Atas Pengetahuan (Memahami Teori Relasi Kuasa Michel Foucault)
Authors: Syafiuddin Arif
Published: May 2020

This article attempts to outline the concept of power of Michel Foucault based on the major works that he wrote during his lifetime. Foucault asserts that power exists everywhere, especially concerning the relationship between power and discourse of knowledge. Here, for him, the will to truth is the expression of the will to power. It is impossible for the knowledge to be neutral and pure. Therefore, there will be always a correlation between the two matters, i.e. the knowledge contains power, just like the power contains knowledge. This means that power is one dimension of the relation. Where there is a relationship, there is a power.
Tasawuf Abd Al-Rahman Al-Sulamī (Perspektif Historis)
Authors: Sofiudin Muh
Published: May 2020

Abu Abd al-Rahman Al-Sulamī (d. 412 H) is known as a great Sufi scholar. In the realm of tasawuf, he formulated tasawuf as in al-muqaddimah fi al-tasawwuf and wrote the biographies of the Sufi scholars in his book Thabaqat al-Sufiyyah. The tasawuf review in the form of biography of the Sufi ulama gives a distinctive picture in the process of formulating the concept of tasawuf. On the other hand, although al-Sulamī is known as a tasawuf briliant thinker, in Indonesia, it turns out to be less prestige than his pupil named al-Qusyairi. In fact, al-Sulamī is al-Qusyairi’s teacher who actually has more scientific authority than his pupil. This fact can be caused by many factors, one of which is the lack of information and references to al-Sulamī.
Tarekat Hizib Nahdlatul Wathan Dan Perannya Dalam Perpolitikan Di Lombok
Authors: Ziadi M. Rohman
Published: May 2020

Tarekat is a Sufi brotherhood in which it contains and practices sufistic principles. In Sufism,there is a very thick concept, namely zuhud. Zuhud is the emptiness of search, which limits his desire to gain the world. From this it can be seen that the Sufic tradition should be reluctant to desire the world, including politics. However, the Hizib Nahdlatul Wathan as a tarekat appeared to be very active in politics, even the founder and Tarekat murshid Hizib Nahdlatul Wathan became a major driver in politics in Lombok. This is interesting, on the one hand the Hizib Nahdlatul Wathan is a tarekat, but on the other hand it looks very active in the politics of Lombok. Therefore,  the authors are interested in studying  more about the Hizib Nahdlatul Wathan and its role in politics in Lombok. There are two problem formulations in this article, namely; what is the concept of teaching the Hizib Nahdlatul Wathan Order? What is the religious foundation of the Hizib Nahdlatul Wathan Order in its political activities in Lombok? To answer the two formulations of the problem the author uses a literature review and interview research method. In addition, the author also uses two theories to dissect the formulation of the problem, namely the tarekat theory and the tarekat and political theory of Martin van Bruinessen. The tarekat theory the author uses to answer the first problem statement. While the theory of tarekat and politics of Martin van Bruinessen, the author uses it to answer the problem statement number two.
Memaknai Ulang Wacana Waria dalam Konteks Indonesia (Analisis Hermeneutika Terhadap Novel “Perempuan Tanpa V”)
Authors: Syafi’i Muhammad
Published: May 2020

The social construction of transvestites which has so far been still far from what is expected, transgenders in general often get stereotypes that have long taken root so that they become individuals/groups who are marginalized in society. They tend to be shunned because religion and morality are big questions due to their tendency to like same-sex. This  construction is entrenched and to this day, they have not received a proper place and are made as human beings as usual. Related to this, there is a novel called "Perempuan Tanpa V" which tells of transvestites in different perspectives. Because of that the writer wants to study this novel and further find out the construction of transvestites he wants to convey. This study uses Gadamer's hermeneutics approach as an analysis knife. The definition of transvestites in this novel  eventually leads to the construction of transvestites who are built more positively, are not discriminatory, and try to break the stereotype of transvestites that has been understood by the community: irregularities and immorality.
EVALUATION OF THE PRODUCTION PLANNING POLICY ALTERNATIVES IN A PET RESIN PRODUCTION PLANT: A CASE STUDY FROM TURKEY
Authors: Demirkan Abdullah Akman , Unutmaz Durmuşoğlu Zeynep Didem
Published: June 2020

Goal: The main purpose of this work is to develop several production planning models for one of bottle grade PET production plants (in Turkey) under different scenarios by considering different levels of inventory (no stock and different levels of safety stocks), different energy sourcing alternatives (natural gas/coal or both) and production throughput (different lot sizes).

Design/Methodology/Approach: Deterministic multi-product multi-period single level mixed integer linear programming model is presented. The model is implemented for the above defined scenarios. We have also considered the total emission produced for different energy alternatives.

Results: The models for the different scenarios have shown that significant performance improvements can be achieved by changing the parameters/policies of the production. The best model obtained has yielded 6.6% of profit improvement and 6.9% of cost reduction.

Limitations of the investigation: Planning horizon of this work could cover the data of years 2014 to 2018. However, the actual data employed for this study is limited with one year due to unavailability of further data. In addition to this, improvement of current production planning approach of the plant by implementation of proposed model is one of the objectives of this study to see success rate of model. Though, this couldn’t be realized. We hypothetically tested the improvement provided by the proposed model, therefore we can’t analyze the actual improvement.

Practical implications: Interactions among optimal results obtained by running model with different scenarios and their effect on selected performance variables are the main contribution of this work. Similar methodology could be used at other PET resin manufacturing plants or alternatively the production facilities having similar type of continuous manufacturing processes to find their optimal levels of inventory, production throughput and proper choice for energy sourcing alternative.

Originality/Value:  The research on the production planning for PET resin industry by considering the different scenarios (levels of inventory / energy sourcing alternatives/ production throughput) is novel as far as we know, and therefore the approach used in this study is expected to be useful for other similar plants.
Diseño de un plan de acción para la empleabilidad de los universitarios
Authors: González-Morales Olga , Santana Vega Lidia E.
Published: May 2020

El aprendizaje basado en competencias permite al alumnado adquirir conocimientos, aprender procedimientos y desarrollar actitudes necesarias para su empleabilidad. El objetivo del artículo es reflexionar sobre el papel actual de la Universidad y sus relaciones con el entorno (gobierno, empresa y sociedad), y presentar un plan de acción para fomentar la empleabilidad de los estudiantes universitarios como instrumento esencial de la política universitaria. Se utiliza una metodología cualitativa para explorar, indagar y analizar la estructura de la universidad y obtener información sobre la percepción de los responsables de las diferentes unidades de gobierno en materia de empleabilidad. Partiendo de la información recogida, se elabora el plan de empleabilidad agrupado en cuatro programas que involucran a la docencia, la investigación, la gestión y la administración universitaria, con sus respectivos instrumentos de actuación; estos programas han de ser gestionados por los diferentes actores y sus respectivas áreas de gobierno.
Examining the intersectionality among teacher race/ethnicity, school context, and risk for occupational stress
Authors: Fitchett Paul G. , Dillard Jendayi , McCarthy Christopher J. , Lambert Richard G. , Mosley Kristen
Published: May 2020

Combining secondary data from the National Center for Education Statistics National Teacher Principal Survey (NTPS) and Common Core of Data (CCD), this exploratory study examined the distribution of teacher race/ethnicity across the race/ethnicity of the schools in which they work and the extent that teacher and school race/ethnicity was associated with occupational stress. Findings indicate that teachers are more likely to work in schools with higher concentrations of students who match their own race/ethnicity. Both teacher and school race/ethnicity were unique predictors of a teacher being classified as at-risk for stress. Additional analyses suggested that teachers’ reported race/ethnicity significantly moderated the school effect association with stress risk. These findings have policy implications for how school workplace surveys are used as well as staffing and professional development considerations.
Kandungan Senyawa Beta Karoten pada Spirulina platensis dengan Perlakuan Perbedaan Lama Waktu Pencahayaan
Authors: Hanani Triana , Widowati Ita , Susanto AB
Published: June 2020

Spirulina platensis merupakan salah satu mikroalga yang mengandung pigmen beta karoten. Beta karoten memiliki manfaat sebagai antioksidan dan antikanker. Pertumbuhan mikroalga dipengaruhi oleh berbagai macam faktor lingkungan, salah satunya adalah cahaya. Penelitian ini bertujuan untuk menentukan lama waktu pencahayaan yang baik untuk mengoptimalkan pertumbuhan dan produksi pigmen beta karoten pada S. platensis.Metode yang digunakan adalah eksperimen laboratoris. Mikroalga S. platensis dikultivasi dengan dua perlakuan lama waktu pencahayaan yang berbeda yaitu A: 24 jam Terang dan 0 jam Gelap (24T,0G); dan B: 12 jam Terang dan 12 jam Gelap (12T, 12G). Pertumbuhan sel S. platensis diamati selama 11x24 jam kemudian dipanen. Biomassa basah hasil kultivasi dikeringkan agar mendapat biomassa kering yang akan diekstraksi menggunakan pelarut n-heksana. Ekstrak n-heksana S. platensis kemudian dianalisis kandungan pigmen beta karotennya secara spektrofotometrik.Hasil penelitian menunjukkan bahwa perlakuan perbedaan lama waktu pencahayaan tidakberpengaruh secara nyata terhadap pertumbuhan sel dan  kandungan pigmen beta karoten pada S. platensis. Pertumbuhan sel S. platensis dan kandungan beta karoten tertinggi dihasilkan oleh S. platensis yang dikultur pada pencahayaan 24 Terang dan 0 jam gelap (perlakuan A), yaitu berturut-turut 177,62 x 103 sel/mldan0,00183 µg/g. Spirulina platensis is a microalga containing beta carotene pigment. Beta carotene has the benefit of being antioxidants and anticancer. Various environmental factors influence microalgae growth; one of them is light. The purpose of this research is to determine the best lighting duration to optimize the growth and production of beta carotene pigments in S. platensis. The method used in this research was a laboratory experiment. S. platensis was cultivated with two different lighting duration treatments, i.e.A: 24 hours light, 0-hour dark (24T, 0G), and B: 12 hours light, 12 hours dark (12T, 12G). The growth of S. platensis was observed for 11x24 hours and then harvested. The biomass of S. plantesis was then dried and extracted using n-hexane and analyzed for its beta carotene pigment content spectrophotometrically. The result showed that lighting duration treatment had an insignificant effect on cell growth and beta carotene content  ofS.platensis. The optimum growth and beta carotene concentration were optimally achieved by S.  platensis cell cultivated in 24 hours light and 0 hours dark, i.e. 177,62 x 103 cell/mL, 0,00183 µg/g respectively.
Micro Structure in Shinzo Abe's Policy Speech at the 195th Assembly Meeting (Critical Discourse of Teun A. van Dijk)
Authors: Rosliana Lina , Mahardika Fajar
Published: May 2020

Speech is a way of expressing ideas in the form of words or discourse that is prepared to be spoken in front of the audience. Speech contains a message that is tailored to the situation when the orator delivers the speech. In addition to the message to be conveyed, the ideology and thoughts of an orator are also reflected in his speech. Therefore, an orator must have expertise in delivering his speech.This research is aims to determine the purpose and background of the Shinzo Abe Policy Speech at the 195th Session of Diet. The speech was delivered by Abe after he was re-elected as Prime Minister of Japan after the general election on October 22, 2017.Researcher used the critical discourse analysis of Teun A. van Dijk's model to dissect the ideology contained in the speech to focus on text analysis. Based on the results of this research, it can be interpreted implicit meanings in the text through linguistic elements, such as tematic, skematic, semantic, sintaxs, stilistic, and retoric.
Enhancing Students Motivation in Japanese Conversation (Online Course): through CM
Authors: Ginanjar Pika Yestia
Published: May 2020

This paper focuses on the study and teaching strategy of Japanese conversation. The goal of the paper is to analyze the motivation of the students learning experience through CM as a media source of the study, which can lead students to enhance their level of proficiency. The study used a qualitative method of the case study Japanese conversation lecture. Conversation lectures are usually done by memorizing text or role-play using existing text. The idea of this study is similar to role-play but, through CM students can learn pronunciation, articulation, and intonation from the native (actor) directly. This study represents the first stage of a research project aimed at raising student confidence and enhancing Japanese fluencies. The major finding was that a clear majority of students reported a considerably high motivation according to the use of terms ‘tanoshikatta’ and ‘omoshiroi’ on their feedback. It says that students were interested to do the assessment.
Study Of Syntactic Features And Meaning Of The Limitative Expression “saja” In Indonesian, And The Application In Japanese Translation
Authors: Novella Utari
Published: May 2020

Indonesian is the word order of SVO. The limitative expression in Indonesian generally functions as an adverb in the sentence. Adverbs to express limitative expression in Indonesian are classified in some variations. In this paper, the researcher clarified the structure and meaning of limitative expression saja in Indonesian. Referring to the term used by Alwi (1998), Sneddon (2000) and Chaer (2009), saja appears to the right of nouns and verbs. Sneddon (2006) uses the word ‘limiter’ to show the meaning of saja. The research methodology used descriptive using actual data. Data analysis was conducted using theory, as stated by Alwi (1998), Sneddon (2000, 2006), and Chaer (2009). When translated into Japanese, the meaning of saja can be converted into various particles. The definition of each of the particles that express the limitation is considered based on the theory of Sawada (2007), Numata (2009), and Nitta (2009). The results of the research are, saja can be classified into five categories; there are uniqueness, multiplicity, continuity, the minimum limit, and extremity. In Japanese, each meaning can be translated into toritatejoshi dake, bakari, and sae.
Freeter, Arafo, House Husband: Shifting Values of Hegemonic Masculinity and Emphasized Femininity in Four Japanese Television Dramas
Authors: Pasaribu Rouli Esther
Published: May 2020

This study examines the shifting values of masculinity and femininity in four Japanese television dramas: At Home Dad (2004), Around 40 (2008), Freeter, Buy a House (2010), and Wonderful Single Life (2012). These corpus data are analyzed using Connell’s concepts of hegemonic masculinity and emphasized femininity. The findings of this study focus on the following: 1. Characters in the four television dramas challenge the dominant discourses of masculinity and femininity by living as freeters, house husbands, and arafos. 2. To criticize hegemonic masculinity and emphasized femininity, these dramas depict the negative aspects of living a rigid lifestyle encompassed by traditional gender roles and feature main characters who show alternative lifestyles of masculinity and femininity. 3. Hegemonic masculinity and emphasized femininity values shadow the emergence of alternative masculinity and femininity in contemporary Japanese society.
Knowledge, Oligopoly and Labour in Global Value Chains
Authors: Nathan Dev
Published: May 2020

The article explores knowledge in global value chains (GVCs) and its correspondence with the nature of employment in different GVC segments. It starts with the role of knowledge that is protected through intellectual property rights in creating oligopolies in product markets, which are then re-created as oligopolies in the input markets. Knowledge requirements, transmitted through governance relations and the distribution of power within GVCs, lead to the inter-firm distribution of profits within GVCs, and result in differing qualities of employment corresponding to the level of knowledge required in different production segments.
The Engineer … No Longer a Person but a Number on an Excel Sheet: Enterprise Resource Planning and Commoditisation of Labour
Authors: Kamath Rajalaxmi , Sarkar Eureka
Published: May 2020

Based on transcripts provided by 145 engineers working in various information technology organisations in Bangalore, India, the article examines the commoditisation of labour in this sector. In doing so, we specifically want to problematise algorithm-based decision-making embedded in the wider technology of Integrated Development Environments like Enterprise Resource Planning and its ramifications for business and labour processes. Standardisation and modularisation of tasks have made wide inroads in workers’ lives, resulting in a replication of Taylorist mass-production techniques. In unpeeling the “materiality” behind such a development, we elaborate on how efficiency and profit motives of these firms are turning engineers into numbers on a spreadsheet. We conclude by commenting on the implications of this on labour’s organisation and resistance and the future trajectory of working life.
Authors and Keywords Index
Authors: PCPR Editorial
Published: May 2020

Authors and Keywords Index of Volume 4 No. 3
Synthesis and Molecular Docking Study of 1-(3-Chloropropyl)-3,5-Bis((E)-4-Methoxybenzylidene)Piperidin-4-One as Dengue Virus Type 2 (DEN2) NS2B/NS3 Protease Inhibitor Candidate
Authors: Habibi Romi , Herfindo Noval , Hendra Rudi , Teruna Hilwan Y. , Zamri Adel
Published: May 2020

Curcumin is a secondary metabolite compound that has diverse biological activities. However, it is easily hydrolyzed at physiological pH due to the presence of the β-diketone group. Therefore, the replacement of the β-diketone group with mono ketone is expected to overcome this issue. We hereby report the synthesis of mono ketone curcumin derivatives from piperidone by two-steps reactions. The synthesis of curcumin derivate 3 was carried out by Claisen-Schmidt condensation between 4-piperidone and 4-methoxybenzaldehyde using alkaline catalyst. The synthesized curcumin derivate 3 was then reacted with the 1-bromo-3-chloropropane to produce curcumin derivate 5, 1-(3-chloropropyl)-3.5-bis((E)-4-methoxybenzylidene)piperidin-4-one, with 72% yield. The calculated docking scores, the curcumin derivate 5 possessed a better affinity for receptors than the standard panduratin A. The curcumin derivate 5 has a lower docking score of -6.40 kcal/mol compared to panduratin A with value of -5.18 kcal/mol and also had strong binding interactions to DEN2 NS2B/NS3 protease. Thus, this compound is promising candidate as a new anti-dengue agent.
Anti-inflammatory Activity of the Gel Containing a Combination of Neem Leaf Extract and Shallot Extract
Authors: Nurmala Sara , Moerfiah Moerfiah , Purnama Restu T.
Published: May 2020

Neem leaves (Azadirahcta indica A. Juss) and shallots (Allium cepa L) contain flavonoids that are effective as an antioxidant, antibacterial, and anti-inflammatory. The aim of this study was to determine the effective concentration and the duration of treatment of the anti-inflammatory activity of the gel containing a combination of neem leaf extract and shallot extract. These substances have a similar effect, and it is believed that these combinations may effective as an anti-inflammatory at small doses to reduce the side effects. The animals were randomly divided into 6 groups with 5 rats per group. The rats were wound-induced by incising its back (length 1.5 cm, depth 0.7 mm) and were observed for 8 days. Parameters measured were wound’s closure, color, and healing process. Statistical analysis showed that the most effective concentration as an anti-inflammatory was formula 1 (neem leaf extract 3.125%: shallots extract 4%) with the fastest healing time was 5 days. Thus, this formula is one of the effective treatment options for healing wounds.Keywords: neem leaves, shallots, anti-inflammatory, combination, gel
Knowledge, Attitude and Practice of Insulin Use of Diabetic Patients in India
Authors: A P Venkataraman , Kamath Laxminarayana , Shankar Samhita
Published: May 2020

Diabetes mellitus (DM) is a group of common metabolic disorders that share the phenotype of hyperglycemia. India is emerging as the world diabetic capital. Insulin is a therapeutic option to treat either type 1 and type 2 DM. Inadequate awareness about the use of insulin is likely to influence its acceptance and adherence. The present study was done to assess the knowledge, attitude, and practice regarding insulin use among diabetic patients at Victoria Hospital, Bangalore, India. Knowledge, attitude, and practice of sixty diabetic patients (either inpatients or outpatients) were assessed by using a validated questionnaire consisting of 24 items. Scores were allotted to each question and evaluated after applying appropriate statistical tests. The mean age of the patients was 53.51±6.48 years (58.33% males). The mean knowledge score was 9.06±1.88 out of 22, attitude score was 4.78±1.37 out of 12 and practice score was 7.75±1.24 out of 11. The mean score of attitude was better in females compared to male patients (5.32±1.34 vs. 4.4±1.28). Male patients scored 38.57% compared to female patients (41.33%) for the question regarding symptoms of hypoglycemia. 57.14% of male patients and 72% of female patients carried simple carbohydrates when going out. Despite good practice scores, the knowledge and attitude scores regarding insulin use were inadequate. Potential adverse effects of insulin can be avoided and better knowledge, attitude, and practice can be achieved by providing proper education to patients. Keywords: knowledge, attitude, practice, diabetic, insulin
The Pharmacokinetic Drug-Drug Interactions of Andrographis paniculata and Ibuprofen in the Plasma of Healthy Oryctolagus cuniculus Rabbits
Authors: Mutakin Mutakin , Megantara Sandra , Larasati Batari A. , Yogiyanto Yogiyanto , Levita Jutti , Ibrahim Slamet
Published: May 2020

An HPLC method was developed and validated for the pharmacokinetic drug-drug interaction between Andrographis paniculata and ibuprofen in the plasma of Oryctolagus cuniculus rabbits after a single oral administration of the mixture. Nine healthy rabbits (6 males and 3 females, weight 1.68-2.42 kg) were acclimatized for 7 days and were randomly divided into 3 groups. At day-8th the rabbits were group (1) treated with a single oral administration of ibuprofen (dose of 28 mg/kg BW); group (2) treated with a single oral administration of Andrographis paniculata infusion (7.04 mL/kg BW); group (3) treated with a single oral administration of a mixture of Andrographis paniculata (7.04 mL/kg BW) infusion and ibuprofen (dose of 28 mg/kg BW). Plasma samples were prepared by collecting the blood from the marginal ear vein at 0, 30, 60, 90, and 120 minutes after the mixture administration, followed by centrifuging it for 30 minutes 3000 rpm. Chromatographic separation was performed on a LiChrosorb RP-18 with methanol and double-distilled water (70:30) as the mobile phase, flow rate 1 mL/minute. UV detection was set at 227 nm. The absorption and distribution of ibuprofen were fast (Tmax = 30 min; Cmax = 4.02962 mcg/mL), however, interestingly this drug could improve the absorption and distribution of andrographolide in Oryctolagus cuniculus rabbits
Effect of Alginate and Polyethylene Glycol Addition on Physical and Mechanical Characteristics of k-Carrageenan-based Edible Film
Authors: Giyatmi Giyatmi , Poetri Tika Annisa Eka , Irianto Hari Eko , Fransiska Dina , Agusman Agusman
Published: May 2020

Waste disposal problems have attracted scientists around the world to explore the use of renewable resources to produce biodegradable films and coatings. Indonesia has diverse renewable resources of biopolymers that originated from seaweeds such as carrageenan, agar, and alginate. Carrageenan is considered as a potential biopolymer for edible film manufacture due to its characteristic range. This study aimed to develop carrageenan-based edible film using alginate and polyethylene glycol as plasticizers. Edible film made from k-carrageenan with the addition of alginate and polyethylene glycol (PEG) as plasticizers was tested for its mechanical properties, water vapor transmission rate (WVTR) and water solubility.  Blending k-carrageenan with alginate (0%, 0.25%, 0.5%, 0.75%, and 1.0% w/v) increased tensile strength, thickness, and water solubility, but reduced elongation at break, WVTR, and moisture content. The addition of PEG (1%, 2%, and 3% w/v) reduced tensile strength and water solubility, but increased elongation at break, thickness, and moisture content. This study recommended that the best carrageenan-based edible film was obtained from a formula using 1% alginate (w/v) and 1% PEG (w/v).
Estimating Population Mean Power Under Conditions of Heterogeneity and Selection for Significance
Authors: Brunner Jerry , Schimmack Ulrich
Published: May 2020

In scientific fields that use significance tests, statistical power is important for successful replications of significant results because it is the long-run success rate in a series of exact replication studies. For any population of significant results, there is a population of power values of the statistical tests on which conclusions are based. We give exact theoretical results showing how selection for significance affects the distribution of statistical power in a heterogeneous population of significance tests. In a set of large-scale simulation studies, we compare four methods for estimating population mean power of a set of studies selected for significance (a maximum likelihood model, extensions of p-curve and p-uniform, & z-curve). The p-uniform and p-curve methods performed well with a fixed effects size and varying sample sizes. However, when there was substantial variability in effect sizes as well as sample sizes, both methods systematically overestimate mean power. With heterogeneity in effect sizes, the maximum likelihood model produced the most accurate estimates when the distribution of effect sizes matched the assumptions of the model, but z-curve produced more accurate estimates when the assumptions of the maximum likelihood model were not met. We recommend the use of z-curve to estimate the typical power of significant results, which has implications for the replicability of significant results in psychology journals.
Confiabilidade de prensas excêntricas horizontais paralelas de uma linha de fabricação de embalagens metálicas para bebidas
Authors: Da Silva Ronaldo Rodrigues , Araújo Tamires Sousa
Published: June 2020

Com o passar do tempo, a manutenção deixou de ser uma atividade corriqueira nas organizações e se tornou fator primordial para a confiabilidade e disponibilidade dos processos produtivos. Com o objetivo de demonstrar a eficiência dos cálculos de Confiabilidade e, assim, propor a Metodologia da Confiabilidade como ferramenta de melhoria em um processo de manutenção de uma linha de produção automatizada foi realizado um relato técnico da aplicação de indicadores de manutenção num ambiente de manufatura em uma multinacional fabricante de latas de alumínio para bebidas. Os cálculos de Confiabilidade foram aplicados em uma linha com nove Prensas Excêntricas Horizontais em paralelo, do setor de estamparia. Para a pesquisa, foram coletados dados históricos de tempo até o reparo e tempo entre falhas do equipamento em estudo. Com o auxílio do software Excel 2013® foi calculado Tempo Médio para Reparo, o Tempo Médio Entre Falha, a Disponibilidade e, por fim, a Confiabilidade individual e do sistema. Com base nos resultados obtidos, identificou-se que o equipamento estudado está em uma fase que apresenta pouco desgaste e que não poderia relatar o número de falhas em um período curto, porém os cálculos evidenciam a relevância do seguimento de manutenção planejada. Assim, o presente estudo indica a manutenção preventiva como uma nova estratégia para prevenir as falhas.
Replanejamento de bases de despacho de veículos de resgate: um estudo de caso no Rio de Janeiro - Brasil
Authors: Ferrari Thayse , Camara Marcus Vinicius Oliveira , Ribeiro Glaydston Mattos
Published: June 2020

Serviços Médicos de Emergência são sistemas de segurança pública responsáveis pelo atendimento pré-hospitalar a pacientes de emergência médica. Neste sentido, Problemas de Localização de Facilidades têm sido aplicados a fim de indicar locais estratégicos para posicionar bases de despacho de veículos de resgate que atendem às ocorrências de emergência. Este trabalho tem como objetivo realizar uma avaliação dos possíveis impactos de um replanejamento das localizações de bases de despacho de veículos de resgate na cobertura e no tempo de resposta do atendimento. Dez cenários foram propostos com variações na quantidade de locais candidatos a receber bases de despacho de veículos de resgate, com ou sem limitação de número de bases a serem abertas. Esses cenários foram aplicados a um estudo de caso real no município do Rio de Janeiro – Brasil. As análises verificaram que melhorias na disposição das bases, aliadas à redistribuição de veículos entre elas, mostraram-se capazes de impactar de maneira significativa o atendimento da população. Além disso, a maximização deste objetivo, cobertura da população, manifestou-se como o mais expressivo na função objetivo do modelo utilizado.
Diseño de ventilador mecánico emergente en modo asistido/controlado y espontáneo por presión
Authors: Flor Omar , Naranjo César , Tapia Jeysson , Flores Evelyn , Coba Alfredo , Chango Eduardo
Published: May 2020

En este trabajo se presenta el diseño de un ventilador mecánico de carácter emergente y que permite el control de variables como el pico de presión inspiratoria (PIP), Presión Positiva al Final de la Espiración (PEEP), Frecuencia Respiratoria (FR), Tiempo Inspiratorio (Ti), Pausa Inspiratoria (Pause ins), Sensibilidad de Disparo (Trigger), Apnea en Modo Espontáneo (Apnea). Para el diseño, se consideró la experiencia previa en el manejo de ventiladores mecánicos de uso médico y el uso de componentes inoxidables (acero 316) de tipo industrial y equipo médico. Este ventilador permite control mandatorio, selección y monitoreo de parámetros mínimos necesarios para dar soporte vital a pacientes con deficiencia respiratoria aguda.
MÁSCARAS COBREM O ROSTO, A FOME DESMASCARA O RESTO: COVID-19 E O ENFRENTAMENTO À FOME NO BRASIL
Authors: Sipioni Marcelo Eliseu , Riquieri Manuella Ribeiro Lira , Barbosa Jeanine Pacheco Moreira , Biscotto Denise Barbieri , Sarti Thiago Dias , Andrade Maria Angélica Carvalho
Published: May 2020

O ano de 2020 ficará marcado pela história sanitária mundial devido à pandemia de COVID-19, provocada pelo vírus SARS-CoV-2, ou o novo coronavírus. Dentre as ações tomadas pelas autoridades sanitárias internacionais, a mais importante e impactante é o isolamento social. Tal medida, fundamental para conter o avanço da pandemia, traz consigo inúmeras consequências esperadas no campo econômico e social, dentre elas o aumento da miséria e da fome. Este artigo busca problematizar essa questão sob o aspecto político e técnico das políticas de segurança alimentar e nutricional. Resgata os diferentes contextos em que o país atuou no combate à fome, culminando na situação atual de secundarização das políticas sociais no país. Apresenta diversas potências nos programas existentes na agenda pública como forma de amenizar as consequências da fome, sugerindo-se também adaptações em suas implantações no contexto da pandemia. Por fim, reforça-se a importância do papel do Estado como protagonista do combate à fome e da redução da miséria no país de forma estrutural, assumindo o fortalecimento das políticas sociais já existentes.
Identificación de insectos plaga, predadores y hongos fitopatógenos de Cucurbita moschata Loche
Authors: Esquen-Bayona Damaris , Iglesias-Osores Sebastian , Arias Carmen Patricia Calderon
Published: June 2020

Objetivo: Identificación de insectos plaga, predatores y hongos fitopatógenos del cultivo de Loche Cucurbita moschata Duch en Ucupe, Mocupe-Lambayeque. Métodos: el muestreo al azar, se tomaron cinco puntos de muestreo por cultivo. Resultados: Bemisia tabaci ataca al cultivo de loche, se encontró causando raspaduras en el envés de las hojas. Thrips tabaci es una plaga que ubica en los brotes más jóvenes. Diaphania nitidalis, esta es la plaga que ocasiona mayor daño, ya que es un insecto barrenador que ataca al fruto, tallos y flores. Entre los controladores: Chrysoperla externa, Rhinacloa sp., Neides sp., Orius sp. y Cicloneda sanguínea. Entre los hongos fitopatógenos encontrados Cunninghamella spp., Colletotrichium sp., Memnoniella sp., Verticillium sp., Cladosporium sp., Stemphylium sp.