bluuebunny/crossref_metadata_2025 huggingface dataset:
The effects of assessment instruction and test anxiety on divergent components of creative problem-solving tasks
Authors: Prokofieva Victoria , Fenouillet Fabien , Romero Margarida
Published: October 2024

Introduction

This study looked at how an assessment instruction and test anxiety (TA) can influence divergent thinking (DT) components of creativity in a playful robotic problem-solving task.

Methods

We measured TA and creative performance (TD) under assessment and non-assessment conditions in 122 secondary students engaged in creative problem solving (CPS).

Result

The aspects of DT (fluidity and originality) showed a tendency to be impacted by assessment instruction. Thus, under non-assessment conditions, the learners show higher fluidity and better originality in the first occurrence of the CPS task. In the second occurrence, time spent on CPS decreases. Moreover, the originality turns to be impaired in the second trial and only student under assessment maintain their engagement in the activity. No correlation was found between TA and DT, and no gender or age differences were observed. The results suggest that TA does not influence the performance of the students involved in creative problem-solving processes.

Discussion

We discuss the findings in relation to game-based learning specificities. The assessment instruction in playful activities can be perceived as a positive challenge and even the students showing higher levels of test anxiety do not perceive it as a threat. Furthermore, if time constraints are minimized, the impact of assessment instruction on creative performance might be further reduced. The finding of this study opens promising perspectives to the research on innovative forms of school assessment and creative problem solving.
Mechanisms of ozone-induced neurotoxicity in the development and progression of dementia: a brief review
Authors: Marin-Castañeda Luis A. , Gonzalez-Garibay Guillermo , Garcia-Quintana Isabella , Pacheco-Aispuro Gerónimo , Rubio Carmen
Published: October 2024

Dementia encompasses a spectrum of neurodegenerative disorders significantly impacting global health, with environmental factors increasingly recognized as crucial in their etiology. Among these, ozone, has been identified as a potential exacerbator of neurodegenerative processes, particularly in Alzheimer’s disease (AD). Ozone exposure induces the production of reactive oxygen species (ROS), which penetrate the BBB, leading to oxidative damage in neuronal cells. This oxidative stress is closely linked with mitochondrial dysfunction and lipid peroxidation, processes that are foundational to the pathology observed in dementia, such as neuronal death and protein aggregation. Furthermore, ozone triggers chronic neuroinflammation, exacerbating these neurodegenerative processes and perpetuating a cycle of CNS damage. Recent studies highlight the role of peripheral biomarkers like High Mobility Group Box 1 (HMGB1) and Triggering Receptor Expressed on Myeloid cells 2 (TREM2) in mediating ozone’s effects. Disruption of these and other identified proteins by ozone exposure impairs microglial function and response to amyloid plaques, suggesting a novel pathway through which ozone may influence AD pathology via immune dysregulation. This review discusses the concept of a bidirectional lung-brain axis, illustrating that systemic responses to air pollutants like ozone may reflect and contribute to neurodegenerative processes in the CNS. By delineating these mechanisms, we emphasize the critical need for integrating environmental health management into strategies for the prevention and treatment of dementia.
What is in a look? The accountability of gaze in trajectories to conflict
Authors: Clift Rebecca
Published: October 2024

This study investigates the role of gaze in initiating episodes of conflict by examining, using multimodal conversation analysis, a set of cases in which a recipient is prompted to speak by another’s extended gaze. In these cases, this recipient response may be, e.g., “What,” or a more elaborate demand for an account, such as “Why are you looking at me like that for?” Here we investigate the characteristics of the gaze that prompts such responses, and what actions such responses constitute. While “What” compositionally resembles other-initiated repair, its sequential position characterizes it as a so-called “go-ahead” action. In these cases, the sequential positioning of such gazes, constituting it structurally as a so-called “pre,” alongside its durational characteristics and facial expression, are examined to identify the normative associations of gaze and subsequent conduct that make such gazes accountable.
Oxytocin, the Love Hormone, in Stem Cell Differentiation
Authors: Pampanella Luca , Petrocelli Giovannamaria , Forcellini Federica , Cruciani Sara , Ventura Carlo , Abruzzo Provvidenza Maria , Facchin Federica , Canaider Silvia
Published: October 2024

Oxytocin (OXT) is a neurohypophysial nonapeptide that exerts its effects mainly through the oxytocin receptor (OXTR). Several studies have pointed out the role of OXT in the modulation of stem cell (SC) fate and properties. SCs are undifferentiated cells characterized by a remarkable ability to self-renew and differentiate into various cell types of the body. In this review, we focused on the role of OXT in SC differentiation. Specifically, we summarize and discuss the scientific research examining the effects of OXT on mesodermal SC-derived lineages, including cardiac, myogenic, adipogenic, osteogenic, and chondrogenic differentiation. The available studies related to the effects of OXT on SC differentiation provide little insights about the molecular mechanism mediated by the OXT–OXTR pathway. Further research is needed to fully elucidate these pathways to effectively modulate SC differentiation and develop potential therapeutic applications in regenerative medicine.
Quality of Life and Symptoms of Hospitalized Hematological Cancer Patients
Authors: Konstantinidis Theocharis I. , Tsatsou Ioanna , Tsagkaraki Eleftheria , Chasouraki Evgenia , Saridi Maria , Adamakidou Theodoula , Govina Ourania
Published: October 2024

Patients with hematological malignancies undergo intensive treatment and prolonged hospitalization, thus having a variety of physical and psychosocial symptoms and worse quality of life (QOL). This study aimed to assess the QOL and investigate the symptoms of hospitalized hematological cancer patients. A cross-sectional study was conducted in the hematology clinics and day units of two general hospitals of Heraklion, Crete. Adult patients with hematological malignancy and an adequate understanding of the Greek language participated. A demographic questionnaire, the European Organization for Research and Treatment for Cancer quality assessment questionnaire (EORTC QLQ-C30), and the MD Anderson Symptom Inventory (MDASI) were used. The sample consisted of 120 patients—42.5% were women, with a mean age of 65.6 years. The mean time from diagnosis was 33 months. The global health status of QoL had an average value of 47.1. The highest levels of QOL were found in the subscale of cognitive function (72.8) and the lowest in the role function (46.1). For the EORTC QLQ-C30 symptoms scale, the lowest score was found in nausea-vomiting (11.0) and the highest in fatigue (59.1). In the MDASI, in part I (core symptoms), higher levels but also medium intensities were reported at fatigue (78.3%, mean 3.5), drowsiness (65.0, mean 3.3), and distress (65.8%, mean 2.8). In part II, enjoyment of life (85.8%, mean 5.1) had the highest, and relation with other people (67.5%, mean 3.7) had the lowest scores. The increase in the severity of the core symptoms (part I) was related to females (rho = 0.193, p <0.05) and comorbidities (rho = 0.220, p < 0.05). It was also associated with a significant decrease in all functional domains and increased fatigue (rho = 0.571, p < 0.05) in the EORTC QLQ-C30 questionnaire. The increased global health status was related to males (rho = −0.185, p < 0.05) and physical functioning with younger age (rho = −0.331, p < 0.05), higher education (rho = 0.239, p < 0.05), fewer months from diagnosis (rho = −0.199, p < 0.05), and low comorbidity (rho = −0.209, p < 0.05). Finally, multiple linear regression analysis revealed that the total average symptom score of the MDASI was the most significant factor influencing the global health status of the EORTC QLQ-C30 (β = −4.91, p < 0.001). The increased global health status of the EORTC QLQ C30 was not significantly related (p > 0.05) to the social characteristics of the patients, such as education or employment, which requires further validation. The QoL of hematological cancer patients significantly decreases during treatments due to a considerable number of symptoms that must be taken into consideration for high-quality, individualized care.
Investigation of Laser Ablation Quality Based upon Entropy Analysis of Data Science
Authors: Tsai Chien-Chung , Yiu Tung-Hon
Published: October 2024

Laser ablation is a vital material removal technique, but current methods lack a data-driven approach to assess quality. This study proposes a novel method, employing information entropy, a concept from data science, to evaluate laser ablation quality. By analyzing the randomness associated with the ablation process through the distribution of a probability value (reb), we quantify the uncertainty (entropy) of the ablation. Our research reveals that higher energy levels lead to lower entropy, signifying a more controlled and predictable ablation process. Furthermore, using an interval time closer to the baseline value improves the ablation consistency. Additionally, the analysis suggests that the energy level has a stronger correlation with entropy than the baseline interval time (bit). The entropy decreased by 6.32 from 12.94 at 0.258 mJ to 6.62 at 0.378 mJ, while the change due to the bit was only 2.12 (from 10.84 at bit/2 to 8.72 at bit). This indicates that energy is a more dominant factor for predicting ablation quality. Overall, this work demonstrates the feasibility of information entropy analysis for evaluating laser ablation, paving the way for optimizing laser parameters and achieving a more precise material removal process.
Anisotropy of Reynolds Stresses and Their Dissipation Rates in Lean H2-Air Premixed Flames in Different Combustion Regimes
Authors: Chakraborty Nilanjan , Ghai Sanjeev Kumar , Im Hong G.
Published: October 2024

The interrelation between Reynolds stresses and their dissipation rate tensors for different Karlovitz number values was analysed using a direct numerical simulation (DNS) database of turbulent statistically planar premixed H2-air flames with an equivalence ratio of 0.7. It was found that a significant enhancement of Reynolds stresses and dissipation rates takes place as a result of turbulence generation due to thermal expansion for small and moderate Karlovitz number values. However, both Reynolds stresses and dissipation rates decrease monotonically within the flame brush for large Karlovitz number values, as the flame-generated turbulence becomes overridden by the strong isotropic turbulence. Although there are similarities between the anisotropies of Reynolds stress and its dissipation rate tensors within the flame brush, the anisotropy tensors of these quantities are found to be non-linearly related. The predictions of three different models for the dissipation rate tensor were compared to the results computed from DNS data. It was found that the model relying upon isotropy and a linear dependence between the Reynolds stress and its dissipation rates does not correctly capture the turbulence characteristics within the flame brush for small and moderate Karlovitz number values. In contrast, the models that incorporate the dependence of the invariants of the anisotropy tensor of Reynolds stresses were found to capture the components of dissipation rate tensor for all Karlovitz number conditions.
Trend Prediction of Vibration Signals for Pumped-Storage Units Based on BA-VMD and LSTM
Authors: Hu Nan , Kong Linghua , Zheng Hongyong , Zhou Xulei , Wang Jian , Tao Jian , Li Weijiao , Lin Jianyi
Published: October 2024

Under “dual-carbon” goals and rapid renewable energy growth, increasing start-stop frequency poses new challenges to safe operations of pumped-storage power plant equipment. Ensuring equipment safety and predictive maintenance under complex conditions urgently requires vibration warnings and trend forecasting for pumped-storage units. In this study, the measured vibration-signal characteristics of pumped-storage units in a strong background-noise environment are obtained using a noise-reduction method that integrates BA-VMD and wavelet thresholding. We monitored the vibration-signal data of hydroelectric units over a long period of time, and the measured vibration-signal characteristics of pumped-storage units in a strong background-noise environment are accurately obtained using a noise-reduction method that integrates BA-VMD and wavelet thresholding. In this paper, a BP neural network prediction model, a support vector machine (SVM) prediction model, a convolutional neural network (CNN) prediction model, and a long short-term memory network (LSTM) prediction model are used to predict the trend of vibration signals of the pumped-storage unit under different operating conditions. The model prediction effect is analyzed by using the different error evaluation functions, and the prediction results are compared with the predicted results of the four different methods. By comparing the prediction effects of the four different methods, it is concluded that LSTM has higher prediction accuracy and can predict the vibration trends of hydropower units more accurately.
Methanol Equilibrium Curves of Power Transformer Oil–Paper Insulation
Authors: Przybylek Piotr
Published: October 2024

To eliminate the problem of the aging of cellulose insulation in the manufacturing stage, a new drying method is being developed based on the use of methanol vapors. Previous studies have shown that the complete removal of methanol from the cellulose insulation after the drying process is very difficult. Therefore, it is necessary to check how the remaining methanol after drying affects the properties of both the cellulose materials and mineral oil. To conduct such studies, it is necessary to know the methanol content in oil that can be expected depending on its initial content in the cellulose materials and the temperature of the insulation system. Therefore, the main goal of this work is to develop methanol equilibrium curves for oil–paper insulation. To achieve the assumed goal, three-stage studies were conducted. A gas chromatograph equipped with a flame ionization detector was used in all stages of these studies. The gas partition coefficient between oil and air was determined for a temperature of 70 °C. The key experimental finding was the development of methanol equilibrium curves for oil–paper insulation. Thanks to this achievement, it is possible to estimate the methanol content in cellulose materials and mineral oil depending on the insulation temperature. Such data are necessary, among others, to plan appropriate studies aimed at assessing the impact of methanol content on the dielectric and physicochemical properties of these materials, important from the point of view of the operation of power transformers.
Energy-Efficient and Smart Bicycle Lamps: A Comprehensive Review
Authors: Fryc Irena , Listowski Maciej , Fan Jiajie , Czyżewski Dariusz
Published: October 2024

In this review paper, information about bicycle lamp technical parameters is provided. The review is based on the searched Web of Science (WoS) and Scopus bibliographic databases and Transportation Research Information Services, which include references to books, technical reports, conference proceedings, and journal articles. This review showed that these papers about bicycle lighting legal rules in given countries are very easy to reach, but deep searching must be performed to find this research paper having the information about types of optical systems and light sources used in bicycle lamps. This research was conducted using PRISMA 2020 assumptions in the area of bicycle lighting technologies and innovations. The information about bicycle lamp technical parameters was obtained on the basis of the examination of technical documents and papers from high-impact journals. The author’s review shows that contemporary bicycle lamps are becoming increasingly smarter and more energy efficient, while also enhancing safety and comfort for cyclists on their routes in and beyond urban environments.
Influence of Temperature and Bedding Planes on the Mode I Fracture Toughness and Fracture Energy of Oil Shale Under Real-Time High-Temperature Conditions
Authors: Yang Shaoqiang , Zhang Qinglun , Yang Dong
Published: October 2024

The anisotropic fracture characteristics of oil shale are crucial in determining reservoir modification parameters and pyrolysis efficiency during in situ oil shale pyrolysis. Therefore, understanding the mechanisms through which temperature and bedding planes influence the fracture behavior of oil shale is vital for advancing the industrialization of in situ pyrolysis technology. In this study, scanning electron microscopy (SEM), CT scanning, and a real-time high-temperature rock fracture toughness testing system were utilized to investigate the spatiotemporal evolution of pores and fractures in oil shale across a temperature range of 20–600 °C, as well as the corresponding evolution of fracture behavior. The results revealed the following: (1) At ambient temperature, oil shale primarily contains inorganic pores and fractures, with sizes ranging from 50 to 140 nm. In the low-temperature range (20–200 °C), heating primarily causes the inward closure of inorganic pores and the expansion of inorganic fractures along bedding planes. In the medium-temperature range (200–400 °C), organic pores and fractures begin to form at around 300 °C, and after 400 °C, the number of organic fractures increases significantly, predominantly along bedding planes. In the high-temperature range (400–600 °C), the number, size, and connectivity of matrix pores and fractures increase markedly with rising temperature, and clay minerals exhibit adhesion, forming vesicle-like structures. (2) At room temperature, fracture toughness is highest in the Arrester direction (KIC-Arr), followed by the Divider direction (KIC-Div), and lowest in the Short-Transverse direction (KIC-Shor). As the temperature increases from 20 °C to 600 °C, both KIC-Arr and KIC-Div initially decrease before increasing, reaching their minimum values at 400 °C and 500 °C, respectively, while KIC-Shor decreases continuously as the temperature increases. (3) The energy required for prefabricated cracks to propagate to failure in all three directions reaches a minimum at 100 °C. Beyond 100 °C, the absorbed energy for crack propagation along the Divider and Short-Transverse directions continues to increase, whereas for cracks propagating in the Arrester direction, the absorbed energy exhibits a ‘W-shaped’ pattern, with troughs at 100 °C and 400 °C. These findings provide essential data for reservoir modification during in situ oil shale pyrolysis.
Experimental Investigation and Chemical Kinetics Analysis of Carbon Dioxide Inhibition on Hydrogen-Enriched Liquefied Petroleum Gas (LPG) Explosions
Authors: Bai Lei , Cheng Fangming , Dong Yuting
Published: October 2024

The utilization of hydrogen-enriched liquefied petroleum gas (LPG) is an effective means of reducing carbon emissions, but the special physical and chemical properties of hydrogen have raised concerns among the public. To delve into the intricate chemical kinetic mechanisms governing the inhibitory effect of CO2 on the explosion of hydrogen-enriched LPG, this study systematically investigated the influence of varying CO2 concentrations (3%, 6%, and 9%) on the explosion characteristics of hydrogen-enriched LPG (hydrogen ratio ranging from 0 to 0.5) within a 20 L spherical explosion chamber. Subsequently, a chemical kinetic analysis was conducted, focusing on the explosion reaction dynamics of the H2/LPG/CO2/Air mixture, encompassing temperature sensitivity assessments and the production rates of key free radicals. The findings reveal that although hydrogen incorporation does not significantly alter the maximum explosion pressure of LPG, it markedly accelerates the explosion reaction rate, posing a challenge for CO2 in effectively inhibiting the explosion of hydrogen-enriched LPG. CO2 functions as a stabilizing third body within the reaction system, diminishing the collision frequency among free radicals, hydrogen molecules, hydrocarbon molecules, and oxygen molecules, thereby slowing down the reaction rate. As the proportion of hydrogen increases, the concentration of ·H radicals, known for their high reactivity, escalates, rapidly completing the propagation phase of the chain reaction and intensifying the overall generation rates of critical free radicals, including ·H, ·O, and ·OH. Notably, the key reaction H+O2⇋O+OH, which governs the reaction temperature, undergoes significant enhancement, further accelerating the explosion reaction rate and ultimately diminishing the inhibitory efficacy of CO2 against the hydrogenated LPG explosion. Furthermore, as the amount of hydrogen added increases, hydrogen’s competitiveness for oxygen within the reaction system markedly improves, attenuating the oxidation of hydrocarbons. Concurrently, the alkane recombination reaction, exemplified by C3H6+CH3(+M)⇋sC4H9(+M), is strengthened. These insights provide valuable understanding of the complex interactions and mechanisms during the explosion of hydrogen-enriched LPG in the presence of CO2, with implications for the safe application of hydrogen-enriched LPG.
Survey of Reliability Challenges and Assessment in Power Grids with High Penetration of Inverter-Based Resources
Authors: Haghighi Rouzbeh , Bui Van-Hai , Wang Mengqi , Su Wencong
Published: October 2024

Decarbonization is driving power systems toward more decentralized, self-governing models. While these technologies improve efficiency, planning, operations, and reduce the carbon footprint, they also introduce new challenges. In modern grids, particularly with the integration of power electronic devices and high penetration of Renewable Energy Sources (RES) and Inverter-Based Resources (IBRs), traditional reliability concepts may no longer ensure adequate performance due to systemic restructuring. This shift necessitates new or significantly modified reliability indices to capture the characteristics of the evolving power system. Ensuring converter reliability is essential for effective planning, which requires precise, component-to-system-level modeling, as different converters impact system performance indicators. However, the existing literature in this field faces a significant limitation, as most studies focus on a singular perspective. Some examine reliability at the device-level, others at the component-level, while broader reviews in power systems often emphasize system-level analysis. In this paper, we aim to bridge these gaps by comprehensively reviewing the interconnections between these levels and analyzing the mutual influence of power converter and system reliability. A key point to highlight is that, with the rapid evolution of modern power grids, decision-makers must adopt a multi-level approach that incorporates insights from all levels to enable more accurate and realistic planning and operational strategies. Our ultimate goal is to provide an in-depth investigation of studies addressing the unique challenges posed by modern power grids. Finally, we will highlight the gaps in the literature and suggest directions for future research.
Advanced Wastewater Treatment: Synergistic Integration of Reverse Electrodialysis with Electrochemical Degradation Driven by Low-Grade Heat
Authors: Leng Qiang , Li Feilong , Tao Zhenxin , Wang Zhanwei , Wu Xi
Published: October 2024

The reverse electrodialysis heat engine (REDHE) represents a transformative innovation that converts low-grade thermal energy into salinity gradient energy (SGE). This crucial form of energy powers reverse electrodialysis (RED) reactors, significantly changing wastewater treatment paradigms. This comprehensive review explores the forefront of this emerging field, offering a critical synthesis of key discoveries and theoretical foundations. This review begins with a summary of various oxidation degradation methods, including cathodic and anodic degradation processes, that can be integrated with RED technology. The degradation principles and characteristics of different RED wastewater treatment systems are also discussed. Then, this review examines the impact of several key operational parameters, degradation circulation modes, and multi-stage series systems on wastewater degradation performance and energy conversion efficiency in RED reactors. The analysis highlights the economic feasibility of using SGE derived from low-grade heat to power RED technology for wastewater treatment, offering the dual benefits of waste heat recovery and effective wastewater processing.
Machine Learning and IoT-Based Solutions in Industrial Applications for Smart Manufacturing: A Critical Review
Authors: Visconti Paolo , Rausa Giuseppe , Del-Valle-Soto Carolina , Velázquez Ramiro , Cafagna Donato , De Fazio Roberto
Published: October 2024

The Internet of Things (IoT) has radically changed the industrial world, enabling the integration of numerous systems and devices into the industrial ecosystem. There are many areas of the manufacturing industry in which IoT has contributed, including plants’ remote monitoring and control, energy efficiency, more efficient resources management, and cost reduction, paving the way for smart manufacturing in the framework of Industry 4.0. This review article provides an up-to-date overview of IoT systems and machine learning (ML) algorithms applied to smart manufacturing (SM), analyzing four main application fields: security, predictive maintenance, process control, and additive manufacturing. In addition, the paper presents a descriptive and comparative overview of ML algorithms mainly used in smart manufacturing. Furthermore, for each discussed topic, a deep comparative analysis of the recent IoT solutions reported in the scientific literature is introduced, dwelling on the architectural aspects, sensing solutions, implemented data analysis strategies, communication tools, performance, and other characteristic parameters. This comparison highlights the strengths and weaknesses of each discussed solution. Finally, the presented work outlines the features and functionalities of future IoT-based systems for smart industry applications.
Evaluation of the Preservation of Chitinozoans in a Case Study of the Katian?—Hirnantian Succession, Eastern Precordillera of Argentina
Authors: Gómez Jessica , di Pasquo Mercedes , Silvestri Leonardo
Published: October 2024

The poor preservation state of chitinozoans recovered from samples of the La Pola (Sandbian–Katian) and Don Braulio formations (Hirnantian-Llandovery), after being processed with standard methods, required significant modifications in processing. The sodium hexametaphosphate technique was used to avoid invasive mechanical procedures. Hence, more complete chitinozoans that preserved original features produced by biological, mechanical, and chemical degradation appeared. The processes that affected the good preservation of the chitinozoan exine are associated with factors inherent to the sedimentary environment, and biological and geological taphonomic effects that occurred in different regions of the Precordillera, added to the important associated tectonic activity. The thermal alteration was also an important factor in the fragile and brittle condition of the organic matter recovered. This transcends the preservation-processing technique relationship to be used. The results obtained from non-standard processing contribute to the paleoenvironmental interpretation of the Pola and Don Braulio successions, which are still widely discussed, and the determination of the most accurate age of the La Pola Formation. The latter will allow us to propose a biostratigraphic correlation between chitinozoan zones and graptolite zones, given the presence of both groups in the succession studied here, and to establish correlations with other successions in the Precordillera and elsewhere.
Exploring the Link Between Physical Activity, Sports Participation, and Loneliness in Adolescents Before and Into the COVID-19 Pandemic: The HUNT Study, Norway
Authors: Rangul Vegar , Sund Erik Reidar , Ingul Jo Magne , Rimehaug Tormod , Pape Kristine , Kvaløy Kirsti
Published: October 2024

Background: The COVID-19 pandemic’s effects on adolescents’ physical activity, sports involvement, and feelings of loneliness remain inadequately understood. This study aimed to explore the shifts in leisure-time physical activity, sports participation, and loneliness among adolescents before and during the pandemic, positing that the pandemic has led to decreased physical activity and sports engagement, as well as heightened loneliness, where more active adolescents experience lower loneliness levels. This study included a prior four-year follow-up cohort from the same region two decades earlier to explore the existence of typical longitudinal aging effects in a cohort not affected by the pandemic. Methods: Prospective and longitudinal data from two cohorts of the Young-HUNT Study two decades apart involving adolescents aged 13–19 years were utilized. The controls were as follows: Cohort 1 from the Young-HUNT1 (YH1) Survey included 2399 adolescents with follow-up in the Young-HUNT2 (YH2) Survey four years later. Cohort 2 included the Young-HUNT4 (YH4) Survey (2017–2019) of 8066 adolescents, with a subset of 1565 participants followed up in the Young-HUNT COVID Survey (YHC) (2021) after exposure to the COVID-19 pandemic and associated restrictions. Changes over time were assessed using McNemar’s tests and dependent sample T-tests, while multinomial logistic regression modeled within-individual changes in loneliness, adjusting for age, gender, and other factors. Results: The findings revealed a significant decline in physical activity and sports participation in both cohorts from early to late adolescence. Additionally, there was a considerable increase in reported loneliness, more after exposure to the pandemic and especially among girls, but without any difference in historical initial levels (between cohorts). Inactive adolescents faced a greater risk of increased loneliness, while those participating in sports had a lower risk of loneliness. Physically inactive boys had a higher risk of loneliness compared with physically active boys at both time points in Cohort 2, which was higher than in the control Cohort 1. There was no historical difference between initial assessments. Conclusion: Adolescents experienced a significant decrease in physical activity and sports participation, along with increased loneliness, from early to late adolescence. Given the protective benefits of physical activity against loneliness and the negative longitudinal trends observed, public health initiatives should focus on increasing physical activity and reducing sports drop-out rates among adolescents to combat rising loneliness.
Social Media and Digital Inequity: Reducing Health Inequities by Closing the Digital Divide
Authors: Jafar Zain , Quick Jonathan D. , Rimányi Eszter , Musuka Godfrey
Published: October 2024

As its usage has grown, social media has positively and negatively impacted public health. Although social media presents known harms to mental health and spreads misinformation, it also offers rapid dissemination of public health information, expanded access to health resources, and a robust source of health information. However, these benefits are not equitably shared due in part to the “digital divide” of unequal access and use of information and communication technologies. Measurable inequalities in digital access exist among regions, with an eight-fold difference between Central Africa (9.8% social media penetration) and Northern Europe (80.2% social media penetration). Digital inequalities also differ by gender, age, and socioeconomic classes within countries. Increased digital access has been positively associated with improved health information and outcomes related to chronic diseases, infectious disease outbreaks, and reproductive health. Given the expanding role of social media in public health and the emerging evidence on the health benefits of digital access, we argue for reducing digital inequities by (1) creating an enabling government policy and regulatory environment that views digital health access as a social determinant of health; (2) targeting public and private investments to expand digital access for underserved regions and populations; (3) making digital access and use affordable to low-resource populations; and (4) improving digital competency among these groups through digital literacy programs.
Long-Term Physical Activity Mitigates Inflammaging Progression in Older Adults Amidst the COVID-19 Pandemic
Authors: dos Santos Carlos André Freitas , Nardy Ariane , Gomes Renato Jimenez , Silva Brenda Rodrigues , Monteiro Fernanda Rodrigues , Rossi Marcelo , do Amaral Jônatas Bussador , Paixão Vitória , Vaisberg Mauro Walter , Amirato Gislene Rocha , Vieira Rodolfo P. , dos Santos Juliana de Melo Batista , Furtado Guilherme Eustaquio , Ribeiro Ana Paula , Colombo-Souza Patrícia , Jacinto Alessandro Ferrari , Bachi Andre Luis Lacerda
Published: October 2024

Background: Inflammaging and physical performance were investigated in older adults before and after the COVID-19 pandemic. Methods: Older women (n = 18) and men (n = 7) (mean age = 73.8 ± 7.1) were evaluated before the COVID-19 pandemic (PRE), 12 months after the lockdown (POST), and 10 months after resuming exercise training (POST-TR). Physical tests [gait speed (GS) and timed-up-and-go (TUG)]; muscle strength (handgrip—HG); and serum cytokine levels were assessed. Results: Older women showed higher GS and TUG at POST than PRE and POST-TR but lower HG at POST-TR than PRE, whereas older men exhibited lower HG at POST and POST-TR than PRE. Both groups presented (1) lower IL-10 and IL-12p70 values in contrast to higher IL-6/IL-10 and IL-8/IL-10 ratios at POST than PRE; (2) higher IL-10 values and lower IL-8/IL-10 ratio at POST-TR than POST; (3) higher IL-12p70/IL-10 ratio at POST-TR than PRE and POST. Particularly, older women showed (4) lower IL-6 values at POST and POST-TR than PRE; (5) lower IL-8 and IL-10 values at POST-TR than POST; (6) and higher TNF-α/IL-10 and IFN-γ/IL-10 ratios at POST than PRE and POST-TR. Significant correlations between the variables were found in both groups. Discussion: During the COVID-19 pandemic, detraining and resumption of exercise training promoted distinct alterations in physical capacity and inflammaging among older women and older men.
Prevalence Trends of Foodborne Pathogens Bacillus cereus, Non-STEC Escherichia coli and Staphylococcus aureus in Ready-to-Eat Foods Sourced from Restaurants, Cafés, Catering and Takeaway Food Premises
Authors: Foxcroft Nicole , Masaka Edmore , Oosthuizen Jacques
Published: October 2024

Foodborne pathogens of Bacillus cereus (B. cereus), non-STEC Escherichia coli (non-STEC E. coli) and Staphylococcus aureus (S. aureus) are currently non-notifiable in Australia unless attributed to a food poisoning outbreak. Due to the lack of data around individual cases and isolations in foods, any changes in prevalence may go undetected. The aim of this study was to determine any changes in the prevalence of B. cereus, non-STEC E. coli and S. aureus in ready-to-eat (RTE) foods sampled from Western Australian restaurants, cafés, catering facilities and takeaway food premises from July 2009 to June 2022. A total of 21,822 microbiological test results from 7329 food samples analysed over this 13-year period were reviewed and analysed. Linear trend graphs derived from the annual prevalence and binary logistic regression models were used to analyse the sample results, which indicated an increase in prevalence for B. cereus. In contrast, a decrease in prevalence for both S. aureus and non-STEC E. coli was determined. Additionally, there were changes in prevalence for the three bacteria in specific months, seasons, specific RTE foods and food premises types. Further research is needed to gain a better understanding of the potential drivers behind these changes in prevalence, including the potential impacts of climate change, COVID-19, legislation and guidelines targeting specific RTE foods, and the difficulty of differentiating B. cereus from B. thuringeniesis using standard testing methods.
Exploring Youths’ Offers to Use E-Cigarettes in Rural Hawai‘i: A Test Development and Validation Study
Authors: Okamoto Scott K. , Subica Andrew M. , Okamura Kelsie H. , An Katlyn J. , Song Sarah D. , Saladino Paula Angela , Carson Adabelle B. , Kon Zarek K. , Marshall Sarah Momilani , Chin Steven Keone , Kaholokula Joseph Keawe‘aimoku , Pagano Ian , Pokhrel Pallav
Published: October 2024

The purpose of this study is to describe the development and initial validation of a survey focused on problematic situations involving e-cigarette use by rural Native Hawaiian and Pacific Islander (NHPI) youths. A 5-phase approach to test development and validation was used. In Phase 1 (Item Generation), survey items were created from a series of focus groups with middle school youths on Hawai‘i Island (N = 69). In Phase 2 (Item Refinement and Selection), situational items were reduced to 40 e-cigarette offer situations that were selected for inclusion in the survey. In Phase 3 (Item Reduction), items were administered to 257 youths from 11 middle, intermediate, or multi-level public or public-charter schools on Hawai‘i Island. Exploratory factor analysis indicated the presence of three factors accounting for 50% of the variance: E-Cigarette Offers from Friends (24%), E-Cigarette Offers from Non-Friends (16%), and Coercive Pressure to Use E-Cigarettes (10%). Hypothesized relationships between offer situations and e-cigarette use were partially confirmed, supporting the construct validity of the survey. This survey helps to fill the scientific and practice gap in measuring ecodevelopmental risk and protection for e-cigarette use and has implications for e-cigarette use prevention with rural, NHPI, and/or Indigenous youth populations.
A Review of Wastewater-Based Epidemiology for the SARS-CoV-2 Virus in Rural, Remote, and Resource-Constrained Settings Internationally: Insights for Implementation, Research, and Policy for First Nations in Canada
Authors: Annan Jessica , Henderson Rita , Gray Mandi , Clark Rhonda Gail , Sarin Chris , Black Kerry
Published: October 2024

Wastewater-based epidemiology (WBE) is regarded as a support tool for detecting and assessing the prevalence of infectious diseases at a population level. For rural, remote, and resource-constrained communities with little access to other public health monitoring tools, WBE can be a low-cost approach to filling gaps in population health knowledge to inform public health risk assessment and decision-making. This rapid review explores and discusses unique considerations of WBE in key settings, with a focus on the detection of the SARS-CoV-2 virus, which has rapidly expanded WBE infrastructure globally. To frame our understanding of possibilities for WBE with First Nations in Alberta, we address the following questions: What are the unique considerations and challenges for WBE under similar contexts in rural, remote, or resource-constrained settings? What are the resources and expertise required to support WBE? This review identifies several unique considerations for WBE in rural, remote, and resource-constrained communities, including costs, accessibility, operator capacity, wastewater infrastructure, and data mobilization—highlighting the need for equity in WBE. In summary, most resource-constrained communities require additional support from external research and/or governmental bodies to undertake WBE.
Curcumin Administration Routes in Breast Cancer Treatment
Authors: Mayo Bianca , Penroz Silvana , Torres Keila , Simón Layla
Published: October 2024

Breast cancer is a public health concern worldwide, characterized by increasing incidence and mortality rates, requiring novel and effective therapeutic strategies. Curcumin is a bioactive compound extracted from turmeric with several pharmacological activities. Curcumin is a multifaceted anticancer agent through mechanisms including the modulation of signaling pathways, inhibition of cell proliferation, induction of apoptosis, and production of reactive oxygen species. However, the poor water solubility and bioavailability of curcumin create important barriers in its clinical application. This review elaborates on the therapeutic potential of curcumin in breast cancer treatment, focusing on the efficacy of different administration routes and synergistic effects with other therapeutic agents. The intravenous administration of curcumin-loaded nanoparticles significantly improves bioavailability and therapeutic outcomes compared to oral routes. Innovative formulations, such as nano-emulsifying drug delivery systems, have shown promise in enhancing oral bioavailability. While intravenous delivery ensures higher bioavailability and direct action on tumor cells, it is more invasive and expensive than oral administration. Advancing research on curcumin in breast cancer treatment is essential for improving therapeutic outcomes and enhancing the quality of life of patients.
Advancements in LAMP-Based Diagnostics: Emerging Techniques and Applications in Viral Detection with a Focus on Herpesviruses in Transplant Patient Management
Authors: Gomes Torres Ana Cláudia Martins Braga , Mathias Carolina , Baal Suelen Cristina Soares , Kohler Ana Flávia , Cunha Mylena Lemes , Blanes Lucas
Published: October 2024

Loop-mediated isothermal amplification (LAMP) is a highly effective molecular diagnostic technique, particularly advantageous for point-of-care (POC) settings. In recent years, LAMP has expanded to include various adaptations such as DARQ-LAMP, QUASR, FLOS-LAMP, displacement probes and molecular beacons. These methods enable multiplex detection of multiple targets in a single reaction, enhancing cost-effectiveness and diagnostic efficiency. Consequently, LAMP has gained significant traction in diagnosing diverse viruses, notably during the COVID-19 pandemic. However, its application for detecting Herpesviridae remains relatively unexplored. This group of viruses is of particular interest due to their latency and potential reactivation, crucial for immunocompromised patients, including organ and hematopoietic stem cell transplant recipients. This review highlights recent advancements in LAMP for virus diagnosis and explores current research trends and future prospects, emphasizing the detection challenges posed by Herpesviridae.
Phosphonates of Pectobacterium atrosepticum: Discovery and Role in Plant–Pathogen Interactions
Authors: Parfirova Olga , Mikshina Polina , Petrova Olga , Smolobochkin Andrey , Pashagin Alexander , Burilov Alexander , Gorshkov Vladimir
Published: October 2024

Many phytopathogens’ gene products that contribute to plant–pathogen interactions remain unexplored. In one of the most harmful phytopathogenic bacterium Pectobacterium atrosepticum (Pba), phosphonate-related genes have been previously shown to be among the most upregulated following host plant colonization. However, phosphonates, compounds characterized by a carbon–phosphorus bond in their composition, have not been described in Pectobacterium species and other phytopathogenic bacteria, with the exception of Pseudomonas syringae and Pantoea ananatis. Our study aimed to determine whether Pba synthesizes extracellular phosphonates and, if so, to analyze their physiological functions. We demonstrated that Pba produces two types of extracellular phosphonates: 2-diethoxyphosphorylethanamine and phenylphosphonic acid. Notably, such structures have not been previously described among natural phosphonates. The production of Pba phosphonates was shown to be positively regulated by quorum sensing and in the presence of pectic compounds. Pba phosphonates were found to have a positive effect on Pba stress resistance and a negative effect on Pba virulence. The discovered Pba phosphonates are discussed as metabolites that enable Pba to control its “harmful properties”, thereby maintaining its ecological niche (the host plant) in a relatively functional state for an extended period.
Identification of Potato StPIN Gene Family and Regulation of Root Development by StPIN4
Authors: Zhang Qian , Liu Qing , Yang Jiangwei , Zhang Ning , Si Huaijun
Published: October 2024

The growth hormone export PIN-FORMED (PIN) is an important carrier for regulating the polar transport of plant growth hormones and plays an important role in plant growth and development. However, little is known about the characteristics and functions of PINs in potatoes. In this study, 10 PIN members were identified from potatoes and named StPIN1, StPIN2, StPIN3, StPIN4, StPIN5, StPIN6, StPIN7, StPIN8, StPIN9, and StPIN10 according to their positions in the potato chromosome In addition, the expression of 10 StPINs was analyzed by qRT-PCR during potato root development. The results showed that the StPIN4 gene plays an important regulatory role in potato root development, and its tissue expression varied greatly. Several cis-regulatory elements related to growth factors were also detected in the promoter region of the StPIN gene. The transgenic overexpressing StPIN4 in potato showed suppressed growth in root length and lateral root number, and StPIN4-interfering plants showed the opposite. These results suggested that StPIN4 plays a key role in the regulation of the potato root architecture.
Roles of Germin-like Protein Family in Response to Seed Germination and Shoot Branching in Brassica napus
Authors: Zhang Qian , Wang Luman , Wang Xinfa , Qiao Jiangwei , Wang Hanzhong
Published: October 2024

Germin-like proteins (GLPs) play important roles in the regulation of various plant development processes, such as seed vigor, root and leaf development and disease resistance, while the roles of GLPs on agronomic traits are rarely studied in Brassica napus. Here, we identified GLPs family genes in rapeseed and analyzed their potential functions. There are 77 GLPs family genes (BnGLPs) in the Zhongshuang11 rapeseed reference genome, divided into a, b, c, d, e, f six subfamilies. Tissue expression profile analysis of BnGLPs revealed the following: e subfamily genes were highly expressed in early stages of silique, cotyledon, vegetative rosette and leaf development; f subfamily genes were highly expressed in seed development; genes of a subfamily were mainly expressed in the root; and genes of b, c, d subfamily exhibited low-level or no expression in above mentioned tissues. RT-qPCR analysis confirmed that the transcripts of two f subfamily members decreased dramatically during seed germination, suggesting that f subfamily proteins may play vital roles in the early stage of seed germination. Transcriptome analysis of axillary buds in sequential developing stages revealed that the transcripts of eight e subfamily genes showed a rapid increase at the beginning of shoot branching, implying that the e subfamily members played vital roles in branch development. These results demonstrate that rapeseed BnGLPs likely play essential roles in seedling development, root development and plant architecture, indicating that harnessing certain BnGLPs may contribute to the improvement of rapeseed yield.