bluuebunny/crossref_metadata_2025 huggingface dataset:
Mechanistic study of PpIX accumulation using the JFCR39 cell panel revealed a role for dynamin 2-mediated exocytosis
Authors: Kitajima Yuya , Ishii Takuya , Kohda Takeo , Ishizuka Masahiro , Yamazaki Kanami , Nishimura Yumiko , Tanaka Tohru , Dan Shingo , Nakajima Motowo
Published: June 2019

5-aminolevulinic acid (5-ALA) has recently been employed for photodynamic diagnosis (ALA-PDD) and photodynamic therapy (ALA-PDT) of various types of cancer because hyperproliferating tumor cells do not utilize oxidative phosphorylation and do not efficiently produce heme; instead, they accumulate protoporphyrin IX (PpIX), which is a precursor of heme that is activated by violet light irradiation that results in the production of red fluorescence and singlet oxygen. The efficiencies of ALA-PDD and ALA-PDT depend on the efficient cellular uptake of 5-ALA and the inefficient excretion of PpIX. We employed the JFCR39 cell panel to determine whether tumor cells originating from different tissues can produce and accumulate PpIX. We also investigated cellular factors/molecules involved in PpIX excretion by tumor cells with the JFCR39 cell panel. Unexpectedly, the expression levels of ABCG2, which has been considered to play a major role in PpIX extracellular transport, did not show a strong correlation with PpIX excretion levels in the JFCR39 cell panel, although an ABCG2 inhibitor significantly increased intracellular PpIX accumulation in several tumor cell lines. In contrast, the expression levels of dynamin 2, which is a cell membrane-associated molecule involved in exocytosis, were correlated with the PpIX excretion levels. Moreover, inhibitors of dynamin significantly suppressed PpIX excretion and increased the intracellular levels of PpIX. This is the first report demonstrating the causal relationship between dynamin 2 expression and PpIX excretion in tumor cells.
Publisher Correction: Extreme risk induced by communities in interdependent networks
Authors: Sun Jiachen , Zhang Rui , Feng Ling , Monterola Christopher , Ma Xiao , Rozenblat Céline , Stanley H. Eugene , Podobnik Boris , Hu Yanqing
Published: June 2019

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Using sulfur bridge oxidation to control electronic coupling and photochemistry in covalent anthracene dimers
Authors: Cruz Chad D. , Yuan Jennifer , Climent Clàudia , Tierce Nathan T. , Christensen Peter R. , Chronister Eric L. , Casanova David , Wolf Michael O. , Bardeen Christopher J.
Published: June 2019

For anthracene dimers bridged by a sulfur atom, modulating the sulfur oxidation state profoundly affects excited state behavior. The SO2-bridge supports long-lived states and photodimerization, while the S-bridge undergoes intersystem crossing.
A new approach to preparation of antisense oligonucleotide samples with microextraction by packed sorbent
Authors: Nuckowski Łukasz , Kaczmarkiewicz Anna , Studzińska Sylwia , Buszewski Bogusław
Published: June 2019

Our research focused on applying microextraction by packed sorbent to extracting antisense oligonucleotides from serum samples.
Comparison of derivatization methods for the quantitative gas chromatographic analysis of oils
Authors: Tammekivi Eliise , Vahur Signe , Kekišev Ott , van der Werf Inez D. , Toom Lauri , Herodes Koit , Leito Ivo
Published: June 2019

Gas chromatographic (GC) determination of quantitative fatty acid composition: which derivatization reagent is the best?
Ultrasensitive Raman sensing of alkaline phosphatase activity in serum based on an enzyme-catalyzed reaction
Authors: Sun Dan , Xu Weiqing , Xu Shuping
Published: June 2019

A schematic diagram of an alkaline phosphatase sensing mechanism based on the transformation of Raman signals caused by an ALP-catalyzed reaction.
Single-molecule conductance investigation of BDT derivatives: an additional pattern found to induce through-space channels beyond π–π stacking
Authors: Li Yunchuan , Xiao Bohuai , Chen Rongsheng , Chen Haijian , Dong Jianqiao , Liu Yichong , Chang Shuai
Published: June 2019

Beyond π–π stacked benzene rings, non-bonded conducting channels are also confirmed in non-strict face-to-face aligned thiophenes or phenyl-thiophene in BDT derivatives.
Synthesis, characterisation, and reactivity of novel pseudocyclic hypervalent iodine reagents with heteroaryl carbonyl substituents
Authors: Qurban Jihan , Elsherbini Mohamed , Alharbi Haifa , Wirth Thomas
Published: June 2019

New heteroatom-containing pseudocyclic iodanes are being introduces as alternatives to the Koser reagent.
Construction of a fluorescent probe for selectively detecting singlet oxygen with a high sensitivity and large concentration range based on a two-step cascade sensing reaction
Authors: Long Lingliang , Yuan Xiangqi , Cao Siyu , Han Yuanyuan , Liu Weiguo , Chen Qian , Gong Aihua , Wang Kun
Published: June 2019

A novel fluorescent probe for detecting1O2on the basis of a two-step cascade reaction has been rationally constructed.
Correction: Core–shell like glass containing lanthanide doped nanocrystals for efficient luminescence
Authors: Liu Qunhuo , Tian Ying , Xiao Zhen , Zhang Jiawei , Tang Wenhua , Jing Xufeng , Zhang Junjie , Xu Shiqing
Published: June 2019

Correction for ‘Core–shell like glass containing lanthanide doped nanocrystals for efficient luminescence’ by Qunhuo Liu et al., Chem. Commun., 2018, 54, 13092–13095.
Unusual temperature-sensitive excimer fluorescence from discrete π–π dimer stacking of anthracene in a crystal
Authors: Shen Yue , Liu Haichao , Cao Jungang , Zhang Shitong , Li Weijun , Yang Bing
Published: June 2019

An unusual blue shift in excimer fluorescence with increasing temperature was observed from a crystal with a discrete π–π anthracene dimer.
Effects of SiO2 modification on the hydrothermal stability of the V2O5/WO3–TiO2 NH3-SCR catalyst: TiO2 structure and vanadia species
Authors: Liu Xuesong , Chen Hongfeng , Wu Xiaodong , Cao Li , Jiang Peng , Yu Qifan , Ma Yue
Published: June 2019

The addition of silica could produce the SixTi1−xO2 solid solutions at the interface in the doped catalyst, which inhibit the direct contact among anatase crystals and improve the stable textural property of V2O5/WO3–TiO2 catalyst.
Regulating the size and spatial distribution of Pd nanoparticles supported by the defect engineered metal–organic framework HKUST-1 and applied in the aerobic oxidation of cinnamyl alcohol
Authors: Guo Penghu , Fu Qi , Yildiz Ceylan , Chen Yen-Ting , Ollegott Kevin , Froese Christian , Kleist Wolfgang , Fischer Roland A. , Wang Yuemin , Muhler Martin , Peng Baoxiang
Published: June 2019

A series of novel Pd@DE-HKUST-1(Cu/Pd) catalysts with different pydc feeding ratios were successfully synthesized. The size regime and the spatial distribution of the Pd NPs can be controlled by the amount of framework incorporated pydc.
Electrically-generated memristor based on inkjet printed silver nanoparticles
Authors: Yoon Kyung Jean , Han Jin-Woo , Moon Dong-Il , Seol Myeong Lok , Meyyappan M. , Kim Han Joon , Hwang Cheol Seong
Published: June 2019

Wide range of memristor behavior is investigated based on electrically-induced oxide electrolyte from inkjet-printed silver.
Ultra-smooth and space-filling mineral films generated via particle accretion processes
Authors: Harris Joe , Mey Ingo P. , Böhm Corinna F. , Trinh Thi Thanh Huyen , Leupold Simon , Prinz Carsten , Tripal Philipp , Palmisano Ralf , Wolf Stephan E.
Published: June 2019

Well-tuned bioinspired mineralization via liquid mineral precursors yields ultra-smooth, space-filling bodies, transgressing the supremum of packing densities of nonclassical crystallization.
Top-down fabrication of small carbon nanotubes
Authors: Cheng Yong , Li Pei , Zhang Qiaobao , Wang Ming-Sheng
Published: June 2019

Uniform and flawless shrinking of carbon nanotubes (CNTs) by using electron irradiation assisted with concurrent thermal annealing inside a TEM, so as to produce CNTs with a desired diameter, including the smallest ones.
Sandwich-like reduced graphene oxide/yolk–shell-structured Fe@Fe3O4/carbonized paper as an efficient freestanding electrode for electrochemical synthesis of ammonia directly from H2O and nitrogen
Authors: Li Chun , Fu Yongsheng , Wu Zhen , Xia Jiawei , Wang Xin
Published: June 2019

A sandwich-like freestanding electrode exhibits excellent selectivity for N2 reduction (FE: 6.25%), a high yield of NH3 and significant stability.
High-density growth of ultrafine PdIr nanowires on graphene: reducing the graphene wrinkles and serving as efficient bifunctional electrocatalysts for water splitting
Authors: Yang Anzhou , Li Tiancheng , Jiang Shuang , Wang Xiaoru , Qiu Xiaoyu , Lei Wu , Tang Yawen
Published: June 2019

The PdIr UNWs/WFG exhibit superior catalytic activity and stability for the OER, HER, and overall water splitting.
Tuning the contact conductance of anchoring groups in single molecule junctions by molecular design
Authors: Šebera Jakub , Lindner Marcin , Gasior Jindřich , Mészáros Gábor , Fuhr Olaf , Mayor Marcel , Valášek Michal , Kolivoška Viliam , Hromadová Magdaléna
Published: June 2019

Molecular design allows tuning of the contact conductance of anchoring groups in single molecule junctions.
Formamide catalyzed activation of carboxylic acids – versatile and cost-efficient amidation and esterification
Authors: Huy Peter H. , Mbouhom Christelle
Published: June 2019

Formamide catalysis enables highly cost-efficient amide C–N and ester C–O bond formation through carboxylic acid chlorides as essential intermediates.
Nicotine protects fetus against LPS-induced fetal growth restriction through ameliorating placental inflammation and vascular development in late pregnancy in rats*
Authors: Bao Junjie , Zou Yong , Liu Yuanyuan , Yuan Li , Garfield Robert E. , Liu Huishu
Published: June 2019

Our previous work has shown that nicotine suppressed lipopolysaccharide (LPS)-induced placental inflammation by inhibiting cytokine release as well as infiltration of leukocytes into the placenta through the cholinergic anti-inflammatory pathway. Nicotine also increased fetal survival and restored pup weight. In the present study, we aim to further investigate if fetal growth restriction (FGR) occurs with LPS treatment, and evaluate the protective effects of nicotine on fetuses in late gestation of rats. Pregnant Sprague–Dawley rats were divided into control group, nicotine group, LPS group and LPS + nicotine group. Rats were first pretreated with nicotine or vehicle by subcutaneous injection on gestation day (GD)14 and GD15, followed by LPS or vehicle intraperitoneal injection on GD16, and were killed on GD18. Loss of fetuses, number and weights of live fetuses and weights of placentas were recorded. Placentas were collected to evaluate placental pathology and determine inflammatory cytokines and vascular endothelial growth factor (VEGF) levels. We found that LPS treatment increased levels of placental inflammatory cytokines and placental pathological damage, decreased levels of VEGF, reduced number of live fetuses and induced FGR. Pretreatment with nicotine reversed LPS-induced high levels of placental inflammatory cytokines, low levels of placental VEGF and placental pathological damage, then rescued the number and weights of live fetuses. These data demonstrated that activation of the cholinergic anti-inflammatory pathway by nicotine protected fetus against LPS-induced FGR through ameliorating placental inflammation and vascular development in late pregnancy in rats. It may be an alternative therapeutic strategy for inflammation- induced FGR in late pregnancy.
A Projection of the Wind Energy in the Black Sea along the 21st Century
Authors: Rusu Liliana
Published: June 2019

The objective of this study is to assess the future wind power potential in the Black Sea based on the wind fields provided by the most recent regional climate projections achieved in the framework of EURO-CORDEX project. The climate change impacts on the wind speed magnitude will bring changes in the local wind power generation. From this perspective, changes in the wind power potential along the 21st century in some reference locations of the Black Sea basin are investigated under the RCP4.5 scenario. The recent wind power conditions for a 30-year period (1976-2005) are assessed based on the results provided by the same RCM (Regional Climate Model) used to generate the future climate projections of the wind fields. The impact of the climate change on the future wind power potential is evaluated by comparisons between historical data and near-future (2021-2050) and more distant future (2071-2100) projections. Under the scenario considered, an increase of the mean wind power was observed until the middle of the 21st century, followed by a small decrease. From the seasonal analysis resulted that, in the reference points located on the western side, the projection of the wind energy in winter time suggests an increase until the end of the century. On the other hand, the linear regressions adjusted to the annual means do not indicate a significant trend.
Efficiency of Space Heating Systems under the Climate Change
Authors: Klimenko Vladimir , Krasheninnikov Sergey , Fedotova Ekaterina
Published: June 2019

Impacts of the climate change on the space heating systems are discussed. We have used the latest global temperature data of the Global Climate Historical Network to demonstrate that the heating and cooling demand combined is decreasing in the world regions with boreal and moderate climate conditions almost everywhere. A simulation approach was developed to assess the impact of the climate change of the efficiency of a modern binary-cycle cogeneration power plant. Both statistical parameters of the air temperature and the thermal circuit of the power plant were modeled in details. It was found that even for a quite optimistic climate scenario the annual efficiency decrease may be as high as 1-2%. This means that careful consideration of the climate-related heating load dynamics is of key importance by implementation and renovation of the district heating systems.
COMET status and plans
Authors: Shoukavy Dzmitry
Published: June 2019

Lepton Flavour Violation in the charged lepton sector (CLFV) is forbidden in the Standard Model. Therefore, the observation of CLFV process would be clear evidence of physics beyond the Standard Model. The COMET (COherent Muon to Electron Transitions) experiment will measure one of these processes: µN → eN at the Japan Proton Accelerator Research Complex in Tokai, Japan. The COMET experiment will be carried out using a two-staged approach. Phase-I of the experiment is aiming at a signal sensitivity of 3.1 × 10−15. Phase-II will use much more intense beam and a more complex transport system to achieve a single-event sensitivity of 3 × 10−17. The article gives an overview of construction and status of the COMET experiment.
Simulation of physics background in Super c-tau factory detector
Authors: Shekhtman L , Ignatov F , Tayursky V
Published: June 2019

Simulation of background particle fluxes generated by colliding beams is performed with FLUKA package for the Super C-Tau factory Detector (SCTD). Two processes are considered as main sources of luminosity generated background: two-photon production of electron-positron pairs and Bha-Bha scattering with bremsstrahlung photon emission (radiative Bha-Bha). The SCTD geometry is described corresponding to the last version of the Conceptual Design Report. The magnetic field based on the calculation in ANSYS is introduced in the model. Main results of the simulation for beam energy of 3 GeV, luminosity of 1035 cm−2s−1 and 1.5 T magnetic field are the following: charged particle fluence in the region of the Inner Tracker (radius 5cm -20 cm, Z between -30cm and 30 cm) is between 105 particles/(cm2s) and ∼103 particles/(cm2s); 1-MeV neutron equivalent fluence for Si in the regions corresponding to electronics of the Inner Tracker and the Drift Chamber is below 1011 n/(cm2y) and absorbed dose is below 100 Gy/y in the hottest regions of the detector.
Simulation of different options of the Inner Tracker for Novosibirsk Super Charm-Tau Factory Detector
Authors: Maltsev T.V. , Shekhtman L.I. , Sokolov A.V. , Vadakeppattu V.K.
Published: June 2019

Inner Tracker of Novosibirsk Super Charm-Tau Factory Detector has to measure momenta of soft hadrons, which do not reach the drift chamber; complement the drift chamber in measuring the momenta; detect secondary vertices of short-lived particles. Thus, proper choice of the option for the Inner Tracker is of significant interest. The simulation of charged pions propagation in the perpendicular direction to the beam axis was carried out with DD4HEP program based on GEANT4. Three options were considered: 4-layered Silicon microstrip detector, 4-layered cylindrical Gas Electron Multiplier (GEM) detector and Time Projection Chamber (TPC). The simulated Detector was located in 1.5 T magnetic field directed along beam axis. The simulation shows that pions with initial momenta less than 50 MeV/c do not pass through the beampipe and cannot be registered. Pions with momenta above 65 MeV/c leave energy depositions in all 4 layers of the Inner Tracker based on Silicon, and their trajectories can be reconstructed. Cylindrical GEM detector provides reconstruction possibility (hits in 4 layers) for pions with momenta more than 60 MeV/c. TPC with thin inner wall provides reconstruction of pions with momenta higher than 55 MeV/c. However, in this case the reconstruction procedure will be much more complicated due to a large number of background particle tracks in the sensitive volume.
Charmonium at BESIII
Authors: Wu Lianjin
Published: June 2019

With large J/ψ and ψ(2S ) data samples, the BESIII Collaboration has performed many studies toward conventional charmonium states below energy 3.686 GeV, which provide information on the internal structure and the interactions of the mesons. In this proceeding, just a few of them, related to (1) OZI suppressed decay search or measurement, (2) “12% rule” test, and (3) theoretical diﬀerent predictions test, is focused on.
Measurement of the Time-like Pion Transition Form Factor at BESIII
Authors: Lenz Thomas , Denig Achim , Redmer Christoph Florian
Published: June 2019

The pion transition form factor is an important input to the dispersive approaches of the Standard Model calculations for the anomalous magnetic moment of the muon. We report the prospects of a first measurement at high momentum transfer in the time-like region performed at BESIII. The aim is to improve the uncertainty of the hadronic light-by-light calculations and to shed light on the BaBar-Belle puzzle in the space-like region.
Measurement of the e+e−→ nn̅ cross section with the SND detector at the VEPP-2000 collider
Authors: Druzhinin V.P. , Serednyakov S.I.
Published: June 2019

New measurement of the e+e−→ nn̅cross section based on the data set recorded in 2017 with the SND detector at the VEPP-2000 e+e− collider is presented.Inthe energyrangefromthe thresholdupto2GeVthe cross section is almost flat. Its average value is 0.5 nb. The polar angle distribution indicates dominanceof the magnetic formfactor GM .
Semileptonic τ decays: powerful probes of non-standard charged current weak interactions
Authors: Roig Pablo
Published: June 2019

When looking for heavy (O(few TeV)) New Physics, the most eﬃcient way to bene?t from both high and low-energy measurements simultaneously is the use of the Standard Model Eﬀective Field Theory (SMEFT). In this talk I highlight the importance of semileptonic τ decays in complementing, in this respect, the traditional low-energy precision observables and high-energy measurements. This is yet another reason for considering hadronic tau decays as golden channels at Belle-II beyond the unquestionable interest of the CP violation anomaly in τ → KS πντ decays, that I also discuss within the eﬀective theory. A couple of new results for τ−→ K− ντ decays are also included.
Fasten bei chronisch entzündlichen
Darmerkrankungen
Authors: Ritzmann-Widderich Martha
Published: June 2019

Die Diagnose einer chronisch entzündlichen Darmerkrankung (CED) bedeutet für die
Betroffenen meist einen Einschnitt in ihren Alltag, sowohl im Beruf als auch
privat. Die Krankheitslast beeinträchtigt auch die Lebensqualität. Zusätzlich
haben CED-Patienten ein 7,5-fach höheres Risiko für Begleiterkrankungen – wie
etwa Asthma, Psoriasis und rheumatoide Arthritis. Erfahrungsheilkundliche
Methoden inkl. Fasten können bei CED eine Remission erzielen.
Therapeutisches Potenzial der nicht kodierenden RNAs für die akute und chronische Myokardischämie
Authors: Rogg Eva-Maria , Dimmeler Stefanie
Published: June 2019

Ein Myokardinfarkt führt unter anderem zum Zelltod von Kardiomyozyten, dem eine mit Fibrose und Remodeling der Ventrikel verbundene Verletzungsreaktion des Herzens folgt. Nicht kodierende RNAs, insbesondere microRNAs, zeigen nach einem Infarkt bekanntlich verschiedene Aktivitäten im Herzen und steuern Verletzungsreaktionen und die Reparatur, indem sie den Tod der Kardiomyozyten, das Gefäßwachstum und die Herzfibrose beeinflussen. Zusätzlich können mehrere microRNAs moduliert werden, um die Herzregeneration zu beeinflussen. Derzeit werden in ersten Phase-I-Studien spezifische microRNA-Inhibitoren für ausgewählte microRNAs, sogenannte antimiRs, zur therapeutischen Anwendung am Menschen getestet. Neuere Studien weisen außerdem darauf hin, dass auch die weniger gut untersuchten langen nicht kodierenden RNAs gezielt beeinflusst werden können, um die Herzfunktion nach Infarkt zu verbessern. Der vorliegende Artikel fasst neuartige Ansätze zusammen, die auf nicht kodierende RNAs als therapeutische Option zur Förderung der Herzreparatur und -regeneration abzielen.
Long-Term Variations of Antithyroperoxidase Antibodies and its Clinical Significance
Authors: Keyhanian Masoumeh , Sarvghadi Farzaneh , Mehran Ladan , Amouzegar Atieh , Beigy Maani , Tohidi Maryam , Azizi Fereidoun
Published: June 2019

Various cut-offs have been proposed for thyroid peroxidase antibodies (TPOAb) positivity. Considering that the long-term trend of TPOAb levels and its positivity incidence is not clearly understood, we conducted the current study to determine the longitudinal variations of TPOAb in a population-based cohort study. We followed 5783 individuals of Tehran Thyroid cohort Study (TTS) for 10 years (4 phases). After exclusions, data of 3493 euthyroid participants remained for analyses. The baseline prevalence rates of TPOAb positivity were 19.8, 17, and 11.4% and the annual incidence rates (95% CI) of TPOAb positivity were 8.53 (8.29–8.77), 7.59 (7.37–7.80) and 6.79 (6.60–6.98) per 1000 persons for the 3 proposed cut-offs of 14.77, 18.38, and 40 U/l; respectively. Although a slightly increasing trend was observed for TPOAb levels (p=0.001) and its conventional positivity (TPOAb>40U/l), the recently proposed cut-offs of 14.77 and 18.38 U/l showed constant TPOAb positivity over 10 years. The time trends of the TPOAb levels among younger participants were significantly different from older participants (time×age effect p=0.004), with the former having an increasing trend and the latter, a relatively decreasing trend. Although the prevalence of TPOAb positivity was significantly (p<0.001) higher among women as compared to men, the longitudinal changes of TPOAb were similar in men and women. TPOAb positivity along with TSH values between 2.5 and 5.0 mU/l or free T4 values between 0.93 and 1.7 ng/dl exerted a significantly increased risk of subclinical or overt hypothyroidism. In an iodine sufficient population, an increasing trend in TPOAb levels was observed in line with the increasing incidence of subclinical and overt hypothyroidism.
Neuroendocrine Control, Inflammation, and Psychological Aspects After Interdisciplinary Therapy in Obese Women
Authors: Moraes Amanda dos Santos , Cipullo Marcos Alberto Taddeo , Poli Vanessa Fadanelli Schoenardie , Rebelo Renata Astride , Ribeiro Eliane Beraldi , Oyama Lila Missae , Silva Stephan Garcia Andrade , Damaso Ana Raimunda , Padovani Ricardo da Costa , Caranti Danielle Arisa
Published: June 2019

Obesity is a chronic and multifactorial disease promoted by positive energy balance. The objective was to evaluate the effects of interdisciplinary therapy in the neuroendocrine control of food intake, inflammatory markers, and psychological aspects in obese women. Forty-seven obese women (43.32±5.82 years, 34.86±3.08 kg/m2), aged 30–50 years, participated in an interdisciplinary lifestyle change therapy, consisting of nutritional counseling, physical exercises, and psychological therapy for 36 weeks. After the long-term therapy, there was a decrease in body weight (Δ –5.36 kg), BMI (Δ –2.01 kg/m2), abdominal (Δ –9.09 cm), hip (Δ –5.03 cm), and thigh (Δ –5.07 cm) perimeters. There was also a significant improvement in body composition, with an increase in fat-free mass (Δ 1.60%) and reduction of body fat (Δ –3.74 kg). The therapy proposed also provided an improvement in depression scores (Δ –6.63), anxiety (Δ –4.07), body image (Δ –25.25), and binge eating (Δ –5.25). There was a significant reduction in serum levels of leptin (Δ –15.62 ng/ml). The interdisciplinary therapy was able to provide both, physical and psychological benefits in energy balance, which enables the use of this model as a feasible clinical strategy for the treatment of obesity.
The Association Between Osteocalcin and C-Reactive Protein; A Relation of Bone with Inflammation: A Systematic Review and Meta-Analysis
Authors: Fatahi Somaye , Ghaedi Ehsan , Mousavi Seyed Mohammad , Bawadi Hiba , Rahmani Jamal , Pezeshki Mehran , Varkaneh Hamed Kord
Published: June 2019

A meta-analysis was performed to summarize the evidence from observational studies regarding the association between serum osteocalcin (OC) and C-reactive protein (CRP). A systemic research of the literature databases including PubMed, SCOPUS, and Google Scholar was performed to identify the relevant studies up to March 2018. We used the random-effects model by the method of DerSimonian and Laird to calculate the overall effect size. Q-test and I
2-statistics were used to assess between-study heterogeneity. In addition, we did subgroup analysis to detect possible sources of heterogeneity based on BMI range, gender, type of study population and age. We identified 21studies of association between serum osteocalcin and CRP eligible for the meta-analysis. The overall effect size showed a significant inverse association between OC and CRP (Fisher’s z=–0.127; 95% CI: –0.166, –0.088, p<0.0001). However, the significant chi-squared statistic result, indicates a heterogeneity of effect sizes (I
2=61.6, df=20, p<0.0001). The subgroup analysis found BMI range, type of study population, and age were the potential sources of heterogeneity. In addition, the strongest correlation was observed in the subgroup of obese subjects (Fisher’s z=–0.264, p=0.002), less than 40 years old (Fisher’s z=–0.115, p<0.0001) and healthy subjects (Fisher’s z=–0.115, p<0.0001). These findings suggest that there is a significant inverse association between serum OC and CRP levels in the adult population.
Biomarker des Myokardinfarkts mit nicht obstruierten Koronararterien
Authors: Tröbs Sven-Oliver , Prochaska Jürgen H. , Wild Philipp Sebastian
Published: June 2019

Der akute Myokardinfarkt mit nicht obstruierten Koronararterien (MINOCA) ist durch ein Fehlen von Koronarstenosen ≥ 50% in der Koronarangiografie gekennzeichnet. Die Datenlage zum MINOCA ist aufgrund der heterogenen Erfassung der Erkrankung und der zumeist ungeklärten Ätiologie in den meisten Studien begrenzt. Der MINOCA weist eine Häufigkeit 5,8 – 11,2% auf und tritt im Schnitt ca. 2 – 3 Jahre früher als der klassische Myokardinfarkt auf. Zum klinischen Profil der Patienten lassen sich aufgrund der Studienlage nur eingeschränkt Aussagen treffen. Diagnostischer Standard ist die kardiale Magnetresonanztomografie, mit der die Klärung der Genese in ca. 75% der Fälle gelingt. Die Letalität ist niedriger als die des klassischen Myokardinfarkts, wobei die Betroffenen vornehmlich an nicht kardiovaskulären Ursachen versterben. Dennoch hat die Troponinkonzentration einen prognostischen Nutzen. Für ACE-Hemmer, AT1-Rezeptorantagonisten und Statine wird ein letalitätssenkender Effekt vermutet.
Umfassende präoperative Evaluation von Patienten mit Lungenkrebs
Authors: Ewig S. , Larrosa-Lombardi S. , Halboos A. , Hecker E.
Published: June 2019

Anatomische Resektionsverfahren sind unverändert etablierter Standard in der kurativen Behandlung des nichtkleinzelligen Lungenkarzinoms in den Stadien I – III und einiger kleinzelliger Lungenkarzinome.

Die Angaben in der Literatur zur Letalität sowie den Komplikationsraten der Resektionsverfahren schwanken jedoch erheblich. Eine Variable, die das Operationsergebnis maßgeblich beeinflusst, ist die Auswahl der Kandidaten für eine Resektion sowie die Bestimmung des Umfangs der Resektion auf dem Boden einer adäquaten Durchführung und Interpretation einer umfassenden mehrdimensionalen präoperativen Evaluation.

Elemente dieser Evaluation sind entsprechend verfügbarer Daten und Leitlinien: der ECOG-Score; kardiales Assessment, ggf. zerebrovaskuläres Assessment; pulmonales Assessment, ggf. mit Ergebnissen der Split-Funktionsanalysen, jeweils ggf. nach Therapie bzw. Adjustierung einer Therapie; bei Patienten über 70 Jahren: Score zur allgemeinen Funktionalität (IADL).

Im Rahmen dieser Evaluation ergeben sich demnach 3 verschiedene Risikogruppen: Patienten mit einem geringen Risiko für intra- und postoperative Komplikationen und Letalität; Patienten mit einem entsprechend erhöhten Risiko; Patienten, die als inoperabel eingeschätzt werden.

Um eine autonome Entscheidung des Patienten über die optimale Therapie auf dem Hintergrund definierter Risiken zu ermöglichen, ist zudem auch die Kenntnis des Patienten, seiner Präferenzen und Wertmaßstäbe sowie seiner familiären und sozialen Einbindung unverzichtbar.
Moderate Consumption of Red Meat, Compared to Soy or Non-Soy Legume, Has No Adverse Effect on Cardio-Metabolic Factors in Patients with Type 2 Diabetes
Authors: Hassanzadeh-Rostami Zahra , Hemmatdar Zeinab , Pishdad Gholam Reza , Faghih Shiva
Published: June 2019

Background Recently, it has been proposed that red meat consumption could enhance risk of diabetes and worsen lipid profile and glycemic status, in comparison with soy or non-soy legume, but the results of clinical trials are controversial.

Objectives This study aimed to compare the effect of red meat, soy bean, and non-soy legume consumption on cardio-metabolic factors in patients with type 2 diabetes.

Methods This was a randomized controlled clinical trial which included 75 patients with diabetes, aged 40–65 years. Participants were randomly allocated to receive two servings of red meat (control group), soy bean, or non-soy legume, 3 days a week for 8 weeks. All groups also received a balanced-macronutrients weight maintenance diet. Body composition and cardio-metabolic factors including fasting blood glucose (FBG), fasting insulin, glycated hemoglobin (HbA1c), serum lipids, and blood pressure were measured at baseline and endpoint of the study. Quantitative insulin sensitivity check index (QUICKI) score and Framingham risk score (FRS) were also computed.

Results We found no significant differences in changes of FBG, fasting insulin, HbA1c, QUICKI score, serum lipids, FRS, and systolic and diastolic blood pressure among the 3 groups. Within group analysis showed that FRS reduced significantly in all groups (P<0.05). In addition, systolic (P=0.01) and diastolic (P=0.03) blood pressure reduced within red meat group.

Conclusions Compared to soy bean or non-soy legume, moderate consumption of red meat had no adverse effect on cardio-metabolic factors including FBG, fasting insulin, HbA1C, QUICKI score, total cholesterol, low-density lipoprotein , high-density lipoprotein , and blood pressure in adults with type 2 diabetes.
Healing and Mortality Rates Following Toe Amputation in Type 2 Diabetes Mellitus
Authors: Vassallo Ian Mario , Gatt Alfred , Cassar Kevin , Papanas Nikolaos , Formosa Cynthia
Published: June 2019

Background and Aim This single-centre study aimed to determine healing, re-ulceration, re-amputation and mortality rates at one year after toe amputations in patients with type 2 diabetes (T2DM).

Patients and Methods Eighty-one participants with T2DM admitted for toe amputation were included. Patient characteristics, peripheral circulation and neuropathy status were recorded. Subjects were then followed every 3 months post-amputation for a year.

Results Overall, 59.3% of participants underwent further surgery (n=31 to revise the original amputation site and n=17 to amputate a new site). During 12 months, 45.7% of participants presented with a new ulcer at a different site. Mortality was 7.4%. In 12.4% of participants, the amputation site remained incompletely healed. Only 20.9% had no complications in 12 months. At 12 months, 80.2% of study cohort had a completely healed amputation site.

ConclusionIn conclusion, this study highlighted high re-intervention, re-amputation and new ulceration rates. Strategies to improves these outcomes in such high-risk patients are warranted.
Perioperative Complications in Patients with Rheumatoid Arthritis Following Primary Total Knee Arthroplasty: An Analysis of 102,898 Patients
Authors: Vakharia Ajit M. , Cohen-Levy Wayne B. , Vakharia Rushabh M. , Sodhi Nipun , Mont Michael A. , Roche Martin W.
Published: June 2019

There are conflicting results regarding the impact of rheumatoid arthritis (RA) on total knee arthroplasty (TKA) outcomes. Therefore, the purpose of this study was to compare outcomes of patients with and without RA undergoing primary TKA. Specifically, we assessed (1) 90-day medical complications, (2) 90-day readmission rates, (3) short-term implant-related complications, (4) 1-year mortality, and (5) total global 90-day episode-of-care costs. The authors of the study hypothesize that RA would increase the rate of medical- and implant-related complications, readmission rates, and costs. A retrospective level of evidence III study was conducted using the Medicare standard analytical files from the PearlDiver database. Patients were queried using the International Classification of Disease, ninth revision codes. Patients with RA were randomly matched 1:1 to controls according to age, gender, and Charlson's comorbidity index. Two mutually exclusive cohorts were formed. Medical- and implant-related complications, readmission rates, and costs were analyzed and compared between the cohorts. Statistical analysis using logistic regression was performed calculating odds ratios (OR), 95% confidence intervals (95% CI), and their respective p-values. The query returned 102,898 patients with (n = 51,449) and without (n = 51,449) RA undergoing primary TKA within the Medicare database from 2005 to 2014. Patients with RA had greater odds of medical complications (OR: 2.08, 95% CI: 1.98–2.20, p < 0.001), implant complications (OR: 1.30, 95% CI: 1.24–1.36, p < 0.001), 1-year mortality (OR: 1.35, 95% CI: 0.68–2.70, p = 0.39), total 90-day episode-of-care costs ($16,605 vs. 15,716.53; p < 0.001), and 90-day readmission rates were similar between cohorts (OR: 1.08, 95% CI: 1.05–1.12, p < 0.001). RA increases postoperative complications and costs following primary TKA within Medicare patients. Comprehensive preoperative optimization for patients with a diagnosis of RA may mitigate perioperative complications, thus improving patient outcomes, and ultimately reducing episode-of-care costs.
Possible Approach to Esophageal Lung with Long Tracheobronchial Gap
Authors: Ichino Martina , Pugni Lorenza , Zanini Andrea , Morandi Anna , Mosca Fabio , Macchini Francesco
Published: June 2019

Esophageal lung is a rare bronchopulmonary foregut malformation characterized by an anomalous origin of one of the main bronchi which arises from the esophagus. Less than 30 cases are reported in the literature. Therefore, there are no standardized guidelines for the treatment of this condition. We report a case of right esophageal lung diagnosed in a neonate. The patient was treated with thoracoscopic closure of the ectopic main bronchus in the neonatal period, followed by delayed pneumonectomy at 5 months of age. No prosthetic substitute was implanted in the ipsilateral hemithorax after pneumonectomy. The patient is now 4 years old and doing well, postpneumonectomy syndrome was never observed. Our strategy and the possible alternatives are discussed here.
Risikomanagement BEI Der Beschaffung von Vernetzter Medizintechnik: Moderator Zwischen Internen und Externen Akteuren
Authors: Tarras Bernhard
Published: June 2019

Potenzielle Risiken bei der Integration von Medizinprodukten in ein Krankenhaus-Netzwerk müssen möglichst schon im Vorfeld einer anstehenden Beschaffung erkannt und minimiert werden. Der Krankenhauseinkauf steht zunehmend vor der Aufgabe, das Risikomanagement als wesentliche Komponente in ein Beschaffungsprojekt zu integrieren und auf diesem Weg eine Balance aus Sicherheit und ökonomischen Rahmenbedingungen zu schaffen.
Fortbildung: Auch Einkauf ist Change-Management
Authors: Nolte Felix , Oldhafer Martina
Published: June 2019

Auf den ersten Blick gibt es nur wenige Zusammenhänge zwischen den Fachdisziplinen Einkauf und Change-Management. Doch zeigt sich bei einer genaueren Betrachtung, dass der Schein in mancher Hinsicht trügt. Gerade im zahlenorientierten Einkauf können einige wesentliche Prinzipien des Change-Managements einen entscheidenden Unterschied machen.
Erfahrungsbericht: Transporte per Mausklick
Authors: Szlamma Steffen
Published: June 2019

Transporte innerhalb des Krankenhauses sollen termintreu, ressourcensparend und transparent für alle Beteiligten sein. Die Alb Fils Kliniken haben es deshalb mit der vollautomatischen Disposition versucht. Seit November vergangenen Jahres ist eine spezielle Software im Einsatz, die die Transporte selbständig steuert. Jetzt werden Patiententransporte, leere Betten und Materialien nicht mehr per Telefon, sondern per Mausklick angefordert.
Parkraummanagement: Viele Bedürfnisse unter Einen Hut Bringen
Authors: Moll Beate , Scholz Katrin , Wibbeling Sebastian
Published: June 2019

Das Parken wird zunehmend zum Problem: für Mitarbeiter, Besucher, Patienten und Dienstleister. Meist wird dieses Problem zu Lasten der angrenzenden Anwohnerparkbereiche gelöst. Verschiedene neue Ansätze helfen, den Park-Suchverkehr zu reduzieren und zielgerichtet zu lenken.
Argon ionization improvement in a plasma thruster induced by few percent of xenon
Authors: Diop Fatou , Gibert Titaina , Bouchoule André
Published: June 2019

In spite of its high cost, xenon gas is known as both the most efficient and commonly used propellant for plasma thrusters in space technologies. Argon, a gas by far less costly, is widely used in other technologies, but a much lower efficiency of ionization, as obtained for example in closed electron drift thrusters, prevents its use in R&D programs and development of space thrusters. This paper shows that a drastic increase in argon ionization can be obtained in a low power thruster when only a few percent of xenon are added in the argon flow. Besides the increase in the ion beam current in the plume generated by the thruster, a net increase in the ion kinetic energy is observed. These two features are of interest in terms of thrust efficiency. These results, obtained for a small size closed electron drift thruster, could be even more spectacular for higher power devices, suggesting further investigations for space propulsion and/or ion source applications.
Multivariate information processing characterizes fitness of a cascaded gene-transcription machinery
Authors: Biswas Ayan
Published: June 2019

We report that a genetic two-step activation cascade processes diverse flavors of information, e.g., synergy, redundancy, and unique information. Our computations measuring reduction in Shannon entropies and reduction in variances produce differently behaving absolute magnitudes of these informational flavors. We find that similarity can be brought in if these terms are evaluated in fractions with respect to corresponding total information. Each of the input signal and final gene-product is found to generate common or redundant information fractions (mostly) to predict each other, whereas they also complement one another to harness synergistic information fraction, predicting the intermediate biochemical species. For an optimally growing signal to maintain fixed steady-state abundance of activated downstream gene-products, the interaction information fractions for this cascade module shift from net-redundancy to information-independence.
Picosecond pulsed laser ablation of dielectric rods: Angle-dependent ablation process model for laser micromachining
Authors: Boerner P. , Hajri M. , Wahl T. , Weixler J. , Wegener K.
Published: June 2019

The ablation of fused silica and sapphire is investigated from the perspective of laser micromachining. In this study, dielectric rods are machined using a 12 ps pulsed laser at 1064 nm wavelength. The machining of the rods is a calibration method to determine process parameters for an analytical ablation model. More specifically, the ablation threshold fluence and effective penetration depth are determined under process-relevant conditions due to the removal of macroscopic volumes, which leads to a higher accordance. The introduced ablation model predicts macroscopic ablation volumes and ablation efficiencies of dielectric materials as a function of the angle of incidence. Originally, the ablation process model was developed for metals under the normal incidence, but this work extends its applicability to dielectrics. In contrast to metals, the optical penetration depth should be independent of the angle of incidence. Altogether, the presented model is universally applicable and can be seen as a first step toward computer-aided 3D-manufacturing using ultrashort pulsed lasers. The ability to predict ablation volumes and machine heat-sensitive tool materials with high accuracy and precision is demonstrated by the fabrication of end mills made of fused silica and sapphire with a diameter of 1 mm. This shows that picosecond lasers are well suited for the fabrication of such microcutting tools. In particular, the ability of ultrashort pulses to ablate materials independent of their hardness and without any wear makes this technology highly promising for the tooling industry.
The stability-limit conjecture revisited
Authors: Chitnelawong Pheerawich , Sciortino Francesco , Poole Peter H.
Published: June 2019

The stability-limit conjecture (SLC) proposes that the liquid spinodal of water returns to positive pressure in the supercooled region and that the apparent divergence of water’s thermodynamic response functions as temperature decreases are explained by the approach to this re-entrant spinodal. Subsequently, it has been argued that the predictions of the SLC are inconsistent with general thermodynamic principles. Here, we reconsider the thermodynamic viability of the SLC by examining a model equation of state for water which was first studied to clarify the relationship of the SLC to the proposed liquid-liquid phase transition in supercooled water. By demonstrating that a binodal may terminate on a spinodal at a point that is not a critical point, we show that the SLC is thermodynamically permissible in a system that has both a liquid-gas and a liquid-liquid phase transition. We also describe and clarify other unusual thermodynamic behavior that may arise in such a system, particularly that associated with the so-called “critical-point-free” scenario for a liquid-liquid phase transition, which may apply to the case of liquid Si.
Analytical study of oscillatory flow of Maxwell fluid through a rectangular tube
Authors: Wang Shaowei , Li Peilin , Zhao Moli
Published: June 2019

In the present study, the oscillatory flow of Maxwell fluid in a long tube with a rectangular cross section is considered. The analytical expressions for velocity profile and phase difference are obtained, and particularly, the singularities of the exact solution are discussed. Furthermore, the convenient expressions of velocity and phase difference are given explicitly for calculations. The effects of the relaxation time and Deborah number on the velocity profile and phase difference are discussed numerically and graphically.
Plasma kinetic effects on interfacial mix and burn rates in multispatial dimensions
Authors: Yin L. , Albright B. J. , Vold E. L. , Nystrom W. D. , Bird R. F. , Bowers K. J.
Published: June 2019

The physics of mixing in plasmas is of fundamental importance to inertial confinement fusion and high energy density laboratory experiments. Two- and three-dimensional (2D and 3D) particle-in-cell simulations with a binary collision model are used to explore kinetic effects arising during the mixing of plasma media. The applicability of the one-dimensional (1D) ambipolarity condition is evaluated in 2D and 3D simulations of a plasma interface with a sinusoidal perturbation. The 1D ambipolarity condition is found to remain valid in 2D and 3D, as electrons and ions flow together required for J = 0. Simulations of perturbed interfaces show that diffusion-induced total pressure imbalance and hydroflows flatten fine interface structures and drive rapid atomic mix. The atomic mix rate from a structured interface is faster than the ∼t scaling obtained from 1D theory in the small-Knudsen-number limit. Plasma kinetic effects inhibit the growth of the Rayleigh-Taylor instability at small wavelengths and result in a nonmonotonic growth rate scaling with wavenumber k with a maximum at a low k value, much different from Agk (where A is the Atwood number and g is the gravitational constant) as expected in the absence of plasma kinetic effects. Simulations under plasma conditions relevant to MARBLE separated-reactant experiments on Omega and the NIF show kinetic modification of DT fusion reaction rates. With non-Maxwellian distributions and relative drifts between D and T ions, DT reactivity is higher than that inferred from rates using stationary Maxwellian distributions. Reactivity is also found to be reduced in the presence of finite-Knudsen-layer losses.
Seeing strain at the nanometer level with new TEM technique
Authors: Kearns Sarah
Published: June 2019

New technique uses a modified aperture and clever diffraction pattern analysis to measure deformations below the nanometer level with an electron microscope.
The Gippsland Basin: reprocessing reveals new opportunities in a 'mature' basin
Authors: Baillie Peter , Carter Paul , Grahame Jarrad , Zhou Joe , Mudge Nigel
Published: June 2019

Although still one of Australia’s most prolific hydrocarbon provinces, the Gippsland Basin is an enigma. The basin largely owes its success to a single play (top porosity below the regional seal), reflected in an anomalous creaming curve that shows no kick in production due to common ‘step-change’ events such as the application of 3D seismic or exploration of the deep water. It is believed the explanation can be found in depth imaging issues, which have been known in the basin for nearly half a century. Although the offshore basin is generally regarded as mature, the recent development of new imaging technologies has demonstrated solutions to the depth imaging issues.