bluuebunny/crossref_metadata_2025 huggingface dataset:
Retailer’s Dual Role in Digital Marketplaces
Authors: Wulfert Tobias , Schütte Reinhard
Published: March 2022

Digital marketplaces have entered the retail sector and have proven to be a successful business model compared to traditional retailing. Established retailers are increasingly launching digital marketplaces as well as participating in marketplaces of pure online companies. Retailers transforming to digital marketplaces orchestrate formerly independent markets and enable retail transactions between participants while simultaneously selling articles from their own assortment to customers in the digital marketplace (dual role). A retailer’s dual role must be supported by retail information systems. However, this support is not explicitly represented in existing reference architectures for retail information systems. Thus, we propose to develop a reference architecture for retail information systems that facilitates the orchestration of supply- and demand-side participants, selling their own articles, and providing innovation platform services. We apply a design science research approach and present nine architectural requirements that a reference architecture for a multi-sided market business model in retail needs to fulfill (dual role, additional participants, affiliation, matchmaking, variety of services, innovation services, smart services, aggregated assortment, and boundary resources) from the rigor cycle. From the first design iteration, we propose four exemplary, conceptual architectural patterns as a solution for the requirements (matchmaking for participants, innovation platform services, boundary resources, and aggregated assortment). These patterns can form a conceptual reference architecture that guides the design and implementation of information systems.
Short-Term Efficacy and Safety of Non-Ablative Laser Treatment Alone or with Estriol or Moisturizers in Postmenopausal Women with Vulvovaginal Atrophy
Authors: Alvisi Stefania , Lami Alessandra , Baldassarre Maurizio , Lenzi Jacopo , Mancini Ilaria , Seracchioli Renato , Meriggiola Maria Cristina
Published: March 2022

Background

Among treatments for vulvo-vaginal atrophy (VVA), there is a new kind of energy-based device, the non-ablative CO2 laser.

Aim

This study aimed to assess the efficacy and safety of the non-ablative CO2 laser in menopausal women with VVA as a monotherapy or in association with vaginal estriol or moisturizer.

Methods

Seventy-five women with VVA received laser treatment (Laser group), laser plus estriol gel (Laser+E) or laser plus moisturizers (Laser+M). The study protocol consisted of 3 monthly laser sessions (t0, t1, t2) and a gynecological examination at baseline and 1 month after last laser treatment (t3). Objective measures included VHI (Vaginal Health Index) and VuHI (Vulvar Health Index); subjective symptoms of VVA (Dryness, Burning, Itching, Dysuria) evaluated via visual analog scales, sexual function evaluated by FSFI (Female Sexual Function Index), FSDS (Female Sexual Distress Score) and MENQOL (Mopause-specific Quality Of Life). Adverse events and discomfort encountered during the procedure were also assessed.

Outcomes

Primary outcomes were the evaluation of VHI and VuHI and secondary outcomes were changes in VVA symptoms (VAS), sexual function (MENQOL, FSFI, FSDS) and discomfort during the procedure.

Results

Seventy-five women (25 in Laser, 25 in Laser+E and 25 in Laser+M group) completed the study. At t3, mean VHI, VuHI, dryness, burning and itching VAS scores improved significantly with no differences between the groups. The lubrication domain of FSFI improved significantly only in the Laser+M group, while the pain domain improved significantly in all women with no differences between the groups. FSFI and FSDS overall scores and MENQOL sexual domain improved in all women with no significant difference between the groups. The mean score of the pain during the procedure was low at t0 and did not change throughout the study.

Clinical implications

This study extends knowledge concerning the effectiveness of a new non-ablative CO2 laser in post-menopausal women with VVA.

Strengths & limitations

This is one of the first studies on this kind of laser and is the first to compare the effectiveness of laser treatment alone or in combination with vaginal estriol or moisturizers. Parameters of VVA and sexual function were evaluated using validated tools. Study limitations include short follow-up time, the limited number of participants and the absence of a sham-controlled group.

Conclusion

Non-ablative CO2 laser seems to be an effective treatment for VVA in menopausal women. Our preliminary data shows that it can be effective as monotherapy or with adjuvant treatments.
Optimization for Data Analysis
Authors: Wright Stephen J. , Recht Benjamin
Published: March 2022

Optimization techniques are at the core of data science, including data analysis and machine learning. An understanding of basic optimization techniques and their fundamental properties provides important grounding for students, researchers, and practitioners in these areas. This text covers the fundamentals of optimization algorithms in a compact, self-contained way, focusing on the techniques most relevant to data science. An introductory chapter demonstrates that many standard problems in data science can be formulated as optimization problems. Next, many fundamental methods in optimization are described and analyzed, including: gradient and accelerated gradient methods for unconstrained optimization of smooth (especially convex) functions; the stochastic gradient method, a workhorse algorithm in machine learning; the coordinate descent approach; several key algorithms for constrained optimization problems; algorithms for minimizing nonsmooth functions arising in data science; foundations of the analysis of nonsmooth functions and optimization duality; and the back-propagation approach, relevant to neural networks.
The Ghostwriters
Authors: Pavone Tommaso
Published: March 2022

The European Union is often depicted as a cradle of judicial activism and a polity built by courts. Tommaso Pavone shows how this judge-centric narrative conceals a crucial arena for political action. Beneath the radar, Europe's political development unfolded as a struggle between judges who resisted European law and lawyers who pushed them to embrace change. Under the sheepskin of rights-conscious litigants and activist courts, these “Euro-lawyers” sought clients willing to break state laws conflicting with European law, lobbied national judges to uphold European rules, and propelled them to submit noncompliance cases to the European Union's supreme court – the European Court of Justice – by ghostwriting their referrals. By shadowing lawyers who encourage deliberate law-breaking and mobilize courts against their own governments, The Ghostwriters overturns the conventional wisdom regarding the judicial construction of Europe and illuminates how the politics of lawyers can profoundly impact institutional change and transnational governance.
Technology and Language Teaching
Authors: Stickler Ursula
Published: March 2022

This Element is a practical guide for language teachers intending to upgrade their online teaching. During the COVID-19 pandemic many teachers were forced to move their teaching online without proper preparation and support. This has led to frustration and stress, and sometimes decisions based not on sound pedagogy but on technological constraints, requirements and opportunities. To balance this negative experience, a research-based, pedagogy-focussed approach has been taken in this volume: step-by-step, teachers are shown how to make decisions about the choice and usage of online tools, how to adapt their pedagogy and teaching strategies to fit with online learning environments, and how to create a positive learning experience for their students. In six sections this Element takes teachers from epistemological considerations to learning theories, from teacher-centred to learner-centred online tuition, and from technological needs to pedagogic choice, ending with suggestions on how to future-proof language teaching.
Current Concepts of Mixed Pathologies in Neurodegenerative Diseases
Authors: Forrest Shelley L. , Kovacs Gabor G.
Published: March 2022

Neurodegenerative diseases are a pathologically, clinically and genetically diverse group of disorders without effective disease-modifying therapies. Pathologically, these disorders are characterised by disease-specific protein aggregates in neurons and/or glia and referred to as proteinopathies. Many neurodegenerative diseases show pathological overlap with the same abnormally deposited protein occurring in anatomically distinct regions, which give rise to specific patterns of cognitive and motor clinical phenotypes. Sequential distribution patterns of protein inclusions throughout the brain have been described. Rather than occurring in isolation, it is increasingly recognised that combinations of one or more proteinopathies with or without cerebrovascular disease frequently occur in individuals with neurodegenerative diseases. In addition, complex constellations of ageing-related and incidental pathologies associated with tau, TDP-43, Aβ, α-synuclein deposition have been commonly reported in longitudinal ageing studies. This review provides an overview of current classification of neurodegenerative and age-related pathologies and presents the spectrum and complexity of mixed pathologies in community-based, longitudinal ageing studies, in major proteinopathies, and genetic conditions. Mixed pathologies are commonly reported in individuals >65 years with and without cognitive impairment; however, they are increasingly recognised in younger individuals (<65 years). Mixed pathologies are thought to lower the threshold for developing cognitive impairment and dementia. Hereditary neurodegenerative diseases also show a diverse range of mixed pathologies beyond the proteinopathy primarily linked to the genetic abnormality. Cases with mixed pathologies might show a different clinical course, which has prognostic relevance and obvious implications for biomarker and therapy development, and stratifying patients for clinical trials.
Phonetic and Phonological Salience in Tone Processing
Authors: Barzilai Maya L.
Published: March 2022

The aim of this study is to determine whether it is the phonetic or phonological effect on processing that is stronger when the two effects are in conflict. Results are presented from a recall experiment, in which speakers of French and Tłı̨chǫ (Dene, Canada) recall syllables with either H or L tone. While French speakers remembered H syllables more accurately, Tłı̨chǫ speakers remembered L tones more accurately. The findings show simultaneous effects of phonetics and phonology, and have implications for notions of salience and how it can be measured as well as for the different types of salience that are active in speech sound processing.
COVID-19 as a Metaphor: Understanding COVID-19 Through Social Media Users
Authors: Colak Figen Unal
Published: March 2022

Objective:

This study, which aims to reveal the metaphorical perceptions of social media users regarding the term, COVID-19, is in accordance with the phenomenological method.

Method:

The phenomenological method was used in this study. In July 2020, a total of 125 social media users voluntarily participated in this research study and were asked to derive metaphors regarding the concept of COVID-19.

Results:

With the participation of social media users, metaphors about COVID-19 were determined. These metaphors, which were provided completely voluntarily in response to social media posts, reveals that the participants approached the COVID-19 phenomenon with a variety of meanings.

Conclusions:

When the metaphors derived by the participants are examined through different categories, it can be seen that a variety of metaphors are produced and almost all of them attribute negative meanings to COVID-19. A significant part of the metaphors evoke disasters and unexpected events. The absence of more hopeful metaphors regarding the end of the pandemic, may stem from the fact that this study took place during the middle of the pandemic, when discussions of the “new normal” were being made just after the first wave.
Key biological mechanisms involved in high-LET radiation therapies with a focus on DNA damage and repair
Authors: Nikitaki Zacharenia , Velalopoulou Anastasia , Zanni Vassiliki , Tremi Ioanna , Havaki Sophia , Kokkoris Michael , Gorgoulis Vassilis G. , Koumenis Constantinos , Georgakilas Alexandros G.
Published: March 2022

DNA damage and repair studies are at the core of the radiation biology field and represent also the fundamental principles informing radiation therapy (RT). DNA damage levels are a function of radiation dose, whereas the type of damage and biological effects such as DNA damage complexity, depend on radiation quality that is linear energy transfer (LET). Both levels and types of DNA damage determine cell fate, which can include necrosis, apoptosis, senescence or autophagy. Herein, we present an overview of current RT modalities in the light of DNA damage and repair with emphasis on medium to high-LET radiation. Proton radiation is discussed along with its new adaptation of FLASH RT. RT based on α-particles includes brachytherapy and nuclear-RT, that is proton-boron capture therapy (PBCT) and boron-neutron capture therapy (BNCT). We also discuss carbon ion therapy along with combinatorial immune-based therapies and high-LET RT. For each RT modality, we summarise relevant DNA damage studies. Finally, we provide an update of the role of DNA repair in high-LET RT and we explore the biological responses triggered by differential LET and dose.
Importance of radiobiological studies for the advancement of boron neutron capture therapy (BNCT)
Authors: Monti Hughes Andrea
Published: March 2022

Boron neutron capture therapy (BNCT) is a tumour selective particle radiotherapy, based on the administration of boron carriers incorporated preferentially by tumour cells, followed by irradiation with a thermal or epithermal neutron beam. BNCT clinical results to date show therapeutic efficacy, associated with an improvement in patient quality of life and prolonged survival. Translational research in adequate experimental models is necessary to optimise BNCT for different pathologies. This review recapitulates some examples of BNCT radiobiological studies for different pathologies and clinical scenarios, strategies to optimise boron targeting, enhance BNCT therapeutic effect and minimise radiotoxicity. It also describes the radiobiological mechanisms induced by BNCT, and the importance of the detection of biomarkers to monitor and predict the therapeutic efficacy and toxicity of BNCT alone or combined with other strategies. Besides, there is a brief comment on the introduction of accelerator-based neutron sources in BNCT. These sources would expand the clinical BNCT services to more patients, and would help to make BNCT a standard treatment modality for various types of cancer. Radiobiological BNCT studies have been of utmost importance to make progress in BNCT, being essential to design novel, safe and effective clinical BNCT protocols.
Influence of particle polydispersity on bulk migration and size segregation in channel flows
Authors: Di Vaira Nathan J. , Łaniewski-Wołłk Łukasz , Johnson Raymond L. , Aminossadati Saiied M. , Leonardi Christopher R.
Published: March 2022

The shear-induced migration of dense suspensions with continuously distributed (polydisperse) particle sizes is investigated in planar channel flows for the first time. A coupled lattice Boltzmann–discrete element method numerical framework is employed and validated against benchmark experimental results of bulk shear-induced migration and segregation by particle size. Distinct dependence on the particle size distribution is shown in the flowing (non-plugged) regime (where the bulk solid volume fraction,

$\bar{\phi}$

,

$\leq 0.3$

) resulting from a dual dependence on the particle self-diffusivity and local rheology imposed by the particle pressure gradient. Close agreement between statistically equivalent bidisperse and polydisperse suspensions suggests that the bulk migration, and by extension the shear-induced diffusivity, is completely characterised by the first three statistical moments of the particle size distribution. For both bidisperse and polydisperse suspensions in the plugging regime,

$\bar {\phi }\geq 0.4$

, the smallest particles preferentially form the plugs, causing the largest particles to segregate to the channel walls. This effect is accentuated as

$\bar {\phi }$

increases and has not been reported in the literature hitherto. It is proposed that smaller particles preferentially form the plugs due to their higher shear-rate fluctuations, which completely dominate particle motion near the plug where the mean shear rate vanishes. Finally, increasing inertia causes a greater bulk migration towards the channel walls, but increased mid-plane migration for the largest particles due to the dependence of the particle self-diffusivity on the particle Reynolds number. As

$\bar {\phi }$

increases shear-induced migration dominates and these inertial effects disappear, as does dependence on the particle size distribution.
Violent droplet impacts with non-flat surfaces
Authors: Hicks Peter D.
Published: March 2022

The application of Wagner theory to idealised two-dimensional inertially dominated droplet impacts is extended to incorporate non-flat substrates that are continuous functions of distance along the surface. Mixed boundary value problems are solved for the displacement and velocity potentials for both a single impact with an asymmetric substrate and a pair of impacts. The droplet free-surface position and the pressure on the wetted surface are calculated, along with the load and moment on the substrate. For double impacts a void may be formed between the substrate and the droplet free surface. Double impacts are compared with a single asymmetric impact with one half of the equivalent substrate geometry to assess how the free surface, loads and moments are affected by the separation between impact sites. Interactions between symmetric double impacts enhance the liquid penetration between the impact sites and increase the load and moment on each substrate element compared with the corresponding single impact. The time taken for the void between droplet and substrate to become saturated is found assuming the gas pressure build-up and capillary forces are negligible, giving an estimate for the transition time from a partially wetted to a fully wetted surface close to the initial impact site. After the void becomes saturated, the subsequent free-surface evolution is determined and the effect of periodic roughness on the contact line evolution is calculated. For surfaces formed of an array of asperities, secondary impacts which both traps further voids and completely wet the surface are found.
Hydrodynamics of an inertial squirmer and squirmer dumbbell in a tube
Authors: Ouyang Zhenyu , Lin Zhaowu , Yu Zhaosheng , Lin Jianzhong , Phan-Thien Nhan
Published: March 2022

We study the hydrodynamics of a spherical and dumbbell-shaped microswimmer in a tube. Combined with a squirmer model generating tangential surface waves for self-propulsion, a direct-forcing fictitious domain method is employed to simulate the swimming of the microswimmers. We perform the simulations by considering the variations of the swimming Reynolds numbers (Re), the blockage ratios (κ) and the relative distances (ds) between the squirmers of the dumbbell. The results show that the squirmer dumbbell weakens the inertia effects of the fluid more than an individual squirmer. The constrained tube can speed up an inertial pusher (propelled from the rear) and an inertia pusher dumbbell; a greater distance ds results in a slower speed of an inertial pusher dumbbell but a faster speed of an inertial puller (propelled from the front) dumbbell. We also illustrate the swimming stability of a puller (stable) and pusher (unstable) swimming in the tube at Re = 0. At a finite Re, we find that the inertia and the tube constraint competitively affect the swimming stability of the squirmers and squirmer dumbbells. The puller and puller dumbbells swimming in the tube become unstable with increasing Re, whereas an unstable–stable–unstable evolution is found for the pusher and pusher dumbbells. With increasing κ, the puller and puller dumbbells become stable while the pusher and pusher dumbbells become unstable. In addition, we find that a greater ds yields a higher hydrodynamic efficiency η of the inertial squirmer dumbbell.
Receptivity of crossflow instability to discrete roughness amplitude and location
Authors: Zoppini G. , Westerbeek S. , Ragni D. , Kotsonis M.
Published: March 2022

The effect of discrete roughness elements on the development and breakdown of stationary crossflow instability on a swept wing is explored. Receptivity to various element heights and chordwise locations is explored using a combination of experimental and theoretical tools. Forcing configurations, determined based on linear stability predictions, are manufactured and applied on the wing in a low turbulence facility. Measurements are performed using infrared thermography, quantifying the transition front location, and planar particle image velocimetry, providing a reconstruction of stationary crossflow instabilities and their associated growth. Measurements are corroborated with simulations based on nonlinear parabolised stability equations. Results confirm the efficacy of discrete roughness elements in introducing and conditioning stationary crossflow instabilities. Primary instability amplitudes and resulting laminar-turbulent transition location are found to strongly depend on both roughness amplitude and chordwise location. The Reynolds number based on element height is found to satisfactorily approximate the initial forcing amplitude, revealing the importance of local velocity effects in non-zero-pressure gradient flows. Direct estimation of initial perturbation amplitudes from nonlinear simulations suggests the existence of pertinent flow mechanisms in the element vicinity, active in conditioning the onset of modal instabilities. Dedicated velocimetry planes, elucidate the development of a momentum deficit wake which rapidly decays downstream of the element followed by mild growth, representing the first experimental evidence of transient behaviour in swept wing boundary layers. The outcome of this work identifies a strong scalability of the transition dynamics to roughness amplitude and location, warranting the upscaling of roughness elements to more accessible, measurable and spatially resolved configurations in future experiments.
Dynamics of pulsed laser-induced cavities on a liquid–gas interface: from a conical splash to a ‘bullet’ jet
Authors: Rosselló Juan Manuel , Reese Hendrik , Ohl Claus-Dieter
Published: March 2022

The inception of a cavitation bubble in a liquid by focusing a short and intense laser pulse near its free surface develops not only an upwards directed jet, but a second jet of opposite direction into the bulk liquid. When the laser is focused a few microns below the surface, the rapid deposition of energy produces a splash, whose later sealing gives origin to two particularly elongated opposing jets. Interestingly, the evolution of the downward jet flowing into the liquid pool has many similarities to that observed in free water entry experiments, e.g. the creation of a slender and stable cavity in the liquid. The downward jet can reach speeds of up to

$40$

m s

$^{-1}$

and travels distances of more than 15 times the maximum radius of the laser induced cavity before losing momentum. The longer lifetime of this so-called ‘bullet’ jet as compared with conventional cavitation based jets, the alignment of the jet perpendicular to the free surface and the possibility of scaling the phenomenon opens up potential applications when generated on small droplets or in shallow liquids. In this work, the underlying mechanisms behind the formation of the bullet jets are initially investigated by performing a set of experiments designed to address specific questions about the phenomenon under study. Those were followed by numerical simulations used to give a quantitative and detailed explanation to the experimental observations.
Compressible high-pressure lubrication flows in thrust bearings
Authors: Chien S.Y. , Cramer M.S.
Published: March 2022

We present a detailed derivation of the Reynolds equation and its corresponding energy equation for three-dimensional, steady, laminar, compressible flows of single-phase Navier–Stokes fluids in thrust bearings. These equations are shown to be valid over most of the dense and supercritical gas regime except for the vicinity of the thermodynamic critical point. It is shown that the primary thermodynamic function governing the lubrication flow of high-pressure gases is the effective bulk modulus defined as the ratio of the bulk modulus to the shear viscosity. Numerical solutions to our Reynolds equation are obtained using a finite difference scheme for both moderate and high-speed flows. Approximate solutions to our Reynolds equation for high-speed flows are also derived through a perturbation analysis. It is found that boundary layers form on three out of four edges of the thrust pad. At the inner and outer radii of the pad, the flow is governed by a nonlinear heat equation. As the main flow leaves the pad, the flow is governed by a nonlinear relaxation equation. These three boundary layer solutions are rendered consistent by the construction of boundary layer solutions in the corner regions. A composite solution is developed which provides a single approximation and has the same accuracy as the individual approximations in their respective regions of validity.
The long cross-over dynamics of capillary imbibition
Authors: Ruiz-Gutiérrez Élfego , Armstrong Steven , Lévêque Simon , Michel Célestin , Pagonabarraga Ignacio , Wells Gary G. , Hernández-Machado Aurora , Ledesma-Aguilar Rodrigo
Published: March 2022

Spontaneous capillary imbibition is a classical problem in interfacial fluid dynamics with a broad range of applications, from microfluidics to agriculture. Here we study the duration of the cross-over between an initial linear growth of the imbibition front to the diffusive-like growth limit of Washburn's law. We show that local-resistance sources, such as the inertial resistance and the friction caused by the advancing meniscus, always limit the motion of an imbibing front. Both effects give rise to a cross-over of the growth exponent between the linear and the diffusive-like regimes. We show how this cross-over is much longer than previously thought – even longer than the time it takes the liquid to fill the porous medium. Such slowly slowing-down dynamics is likely to cause similar long cross-over phenomena in processes governed by wetting.
First-episode psychotic disorders in the wake of the COVID-19 pandemic: a descriptive review of casereports
Authors: Rittmannsberger Hans , Barth Martin , Malik Peter , Malsiner-Walli Gertraud , Yazdi Kurosch
Published: March 2022

Objective:

Since the onset of COVID-19 pandemic, many case reports and case series dealt with new-onset psychotic disorders in patients either infected withSARS-CoV-2 or thematically linked to the pandemic, but without an infection.Our aim was to provide a comprehensive collection of these reports to illustrate the nature of these psychoses.

Methods:

We conducted a literature search in MEDLINE, Embase, PsycINFO, using search terms regarding first-episode psychotic disorders in the context of corona.

Results:

96 case reports or case series covering 146 patients (62 without and 84 with SARS-CoV-2 infection) were found. Compared to patients without infection, patients with infection showed significantly more often visual hallucinations (28.6% vs 8.1%), confusion (36.9% vs 11.3%), an acute onset of illness (88.5% vs 59.6%) and less often depression (13.1% vs 35.5%) and a delusional content related to the pandemic (29.5% vs 78.3%). Both groups had an equally favourable outcome with a duration of psychosis ≤2 weeks in half and full remission in two-thirds of patients. In patients with infection, signs of inflammation were reported in 78.3% and increased CRP in 58.6%. While reports on patients with infection are continuously published, no report about patients without infection was found after July 2020.

Conclusion:

Cases without infection were considered reactive and originated all from the first wave of the corona pandemic. In cases with infection, inflammation was considered as the main pathogenetic factor but was not found in all patients. Diagnosis was impeded by the overlap of psychosis with delirium.
Hypotrachyna neohorrescens, a new species in the subgenusParmelinopsis(Parmeliaceae) from Brazil
Authors: Rodrigues Andressa S. , da Costa Priscila C. , Lorenz Aline P. , Jungbluth Patrícia
Published: March 2022

This study describes a new species ofHypotrachynasubgenusParmelinopsisfrom the south-eastern Cerrado (Brazilian savannah), a biodiversity hotspot. The species is especially common in open vegetation, including urban environments.Hypotrachyna neohorrescenssp. nov. is morphologically and chemically similar toH. horrescens. Nevertheless, phylogenetic analyses of the nuITS and mtSSU regions revealed thatH. neohorrescensis a distinct species and closely related to the North AmericanH. mcmulliniana, differing by the size of the laciniae and ascospores.
A distinctive profile of family genetic risk scores in a Swedish national sample of cases of fibromyalgia, irritable bowel syndrome, and chronic fatigue syndrome compared to rheumatoid arthritis and major depression
Authors: Kendler Kenneth S. , Rosmalen Judith G.M. , Ohlsson Henrik , Sundquist Jan , Sundquist Kristina
Published: March 2022

Background

Functional somatic disorders (FSD) feature medical symptoms of unclear etiology. Attempts to clarify their origin have been hampered by a lack of rigorous research designs. We sought to clarify the etiology of the FSD by examining the genetic risk patterns for FSD and other related disorders.

Methods

This study was performed in 5 829 186 individuals from Swedish national registers. We quantified familial genetic risk for FSD, internalizing disorders, and somatic disorders in cases of chronic fatigue syndrome (CFS), fibromyalgia (FM), and irritable bowel syndrome (IBS), using a novel method based on aggregate risk in first to fifth degree relatives, adjusting for cohabitation. We compared these profiles with those of a prototypic internalizing psychiatric – major depression (MD) – and a somatic/autoimmune disorder: rheumatoid arthritis (RA).

Results

Patients with FM carry substantial genetic risks not only for FM, but also for pain syndromes and internalizing, autoimmune and sleep disorders. The genetic risk profiles for IBS and CFS are also widely distributed although with lower average risks. By contrast, genetic risk profiles of MD and RA are much more restricted to related conditions.

Conclusion

Patients with FM have a relatively unique family genetic risk score profile with elevated genetic risk across a range of disorders that differs markedly from the profiles of a classic autoimmune disorder (RA) and internalizing disorder (MD). A similar less marked pattern of genetic risks was seen for IBS and CFS. FSD arise from a distinctive pattern of genetic liability for a diversity of psychiatric, autoimmune, pain, sleep, and functional somatic disorders.
Why does the shtyle spread? Street prestige boosts the diffusion of urban vernacular features
Authors: Grondelaers Stefan , Marzo Stefania
Published: March 2022

In this article, we investigate social meaning as a determinant of linguistic diffusion by confronting laboratory and corpus data of Citétaal, a multi-ethnolect that has spread across Flanders. In a speaker evaluation experiment, we found that Citétaal was upgraded on ‘streetwise dynamism’, even by respondents unfamiliar with its migrant origin. From this, we conclude that it is Citétaal's third-order indexicality, pruned of ethnic associations, which carries the diffusion. To determine the relative importance of streetwise cool vis-à-vis other predictors, we studied the diffusion across Twitter of the principal Citétaal shibboleth (/s/ palatalisation). As a production proxy for streetwise cool, we included expressive compensation strategies such as lengthening (verrry), which turned out to be among the main predictors of the Citétaal form. We argue that social meaning is a major change determinant, and that Twitter is the optimum source to track both a diffusion and the factors, including social meaning, which drive it. (Rapid linguistic diffusion, social meaning, streetwise prestige, speaker evaluation experiment, corpus linguistics, Twitter)*
The stability analysis of a 2D Keller–Segel–Navier–Stokes system in fast signal diffusion
Authors: LI MIN , XIANG ZHAOYIN , ZHOU GUANYU
Published: March 2022

This paper investigates the stability of a fully parabolic–parabolic-fluid (PP-fluid) system of the Keller–Segel–Navier–Stokes type in a bounded planar domain under the natural volume-filling hypothesis. In the limit of fast signal diffusion, we first show that the global classical solutions of the PP-fluid system will converge to the solution of the corresponding parabolic–elliptic-fluid (PE-fluid) system. As a by-product, we obtain the global well-posedness of the PE-fluid system for general large initial data. We also establish some new exponential time decay estimates for suitable small initial cell mass, which in particular ensure an improvement of convergence rate on time. To further explore the stability property, we carry out three numerical examples of different types: the nontrivial and trivial equilibriums, and the rotating aggregation. The simulation results illustrate the possibility to achieve the optimal convergence and show the vanishment of the deviation between the PP-fluid system and PE-fluid system for the equilibriums and the drastic fluctuation of error for the rotating solution.
Mouse embryonic stem cells maintain differentiation potency into somatic lineage despite alternation of ploidy
Authors: Imai Hiroyuki , Fujii Wataru , Kusakabe Ken Takeshi , Kiso Yasuo , Kano Kiyoshi
Published: March 2022

Vertebrates, including mammals, are considered to have evolved by whole genome duplications. Although some fish have been reported to be polyploids that have undergone additional genome duplication, there have been no reports of polyploid mammals due to abnormal development after implantation. Furthermore, as the number of physiologically existing tetraploid somatic cells is small, details of the functions of these ploidy-altered cells are not fully understood. In this present study, we aimed to clarify the details of the differentiation potency of tetraploids using tetraploid embryonic stem cells. To clarify the differentiation potency, we used mouse tetraploid embryonic stem cells derived from tetraploid embryos. We presented tetraploid embryonic stem cells differentiated into neural and osteocyte lineage in vitro and tetraploid cells that contributed to various tissues of chimeric embryos ubiquitously in vivo. These results revealed that mouse embryonic stem cells maintain differentiation potency after altering the ploidy. Our results provide an important basis for the differentiation dynamics of germ layers in mammalian polyploid embryogenesis.
Comparison of pregnancy rate in dromedary camel between early-stage embryos and blastocyst transfer produced by somatic cell nuclear transfer using in vitro-matured oocytes
Authors: Son Young-Bum , Yu Xianfeng , Jeong Yeon-Ik , Hossein Mohammad Shamim , Olsson P. Olof , Jeong Yeon-Woo , Choi Eun Ji , Tinson Alex H. , Singh Kuhad Kuldip , Rajesh Singh , Noura Al Shamsi , Hwang Woo-Suk
Published: March 2022

We compared the pregnancy and live birth rates following transfer of early-stage embryos or blastocysts produced by somatic cell nuclear transfer using in vitro-matured oocytes. In total 102 ovaries were collected from dromedary camels at a local abattoir; from these 1048 cumulus–oocytes complexes (COCs) were aspirated and cultured for 42 h in a commercial maturation medium. Metaphase II oocytes were subjected to nuclear transfer. Somatic cell nuclear transfer-derived embryos were cultured in a commercial embryo medium for 2 or 7 days. Next, 71 early-stage embryos were surgically transferred to the left fallopian tube of 28 recipients and 47 blastocysts were transferred to the left uterine horn of 26 recipients. Early pregnancy was detected by serum progesterone (P4), and pregnancy was confirmed using ultrasonography on days 30 and 90 after embryo transfer. Pregnancy rate based on P4 level was 17.86% (5/28) and 11.54% (3/26) for early-stage embryo and blastocyst transfer, respectively. In the early-stage embryo group, out of five recipients, one recipient had lost the pregnancy by the first ultrasonography on day 30; two other recipients aborted at 14 and 24 weeks, and two recipients gave live births. In the blastocyst group, out of three recipients, one lost the pregnancy at an early stage and two recipients gave live births. Therefore, for dromedary camels, we recommend transvaginal blastocyst transfer from the standpoint of the pregnancy and live birth rate, ease of the transfer procedure, and comfort and safety of the recipients.
The expression profile of WNT/β-catanin signalling genes in human oocytes obtained from polycystic ovarian syndrome (PCOS) patients
Authors: Ismail Aya Badeea , Naji Marwan ’Mohammad Saeed’ , Nebih İnci , Tuncel Gulten , Ozbakir Burcu , Temel Sehime Gulsun , Tulay Pinar , Mocan Gamze , Ergoren Mahmut Cerkez
Published: March 2022

Polycystic ovarian syndrome (PCOS) is a chronic hormonal turmoil that is demonstrated in 2.2−27% of women of pre-menopausal age. This disease is a complex multigenic disorder that results from the interaction between excess androgen expression, genetic susceptibility and environmental influences. PCOS is associated with 40% of female infertility and endometrial cancer. The WNT/β-catenin signalling transduction pathway regulates aspects of cell proliferation, migration and cell fate determination in the tissue along with early embryonic development and controls the proper activation of the female reproductive system, along with regulating hormonal activity in ovarian granulosa cells. In the current study, we investigated the expression profiles of WNT/β-catenin signalling pathway genes (AXIN2, FZD4, TCF4, WNT3, WNT4, WNT5A, WNT7A, WNT1, APC, GSK3B and β-catenin) in a total of 13 oocyte samples. Seven of these samples were from polycystic women and six were from healthy women. The results of this study displayed the absence of expression of AXIN2, FZD4, TCF4, WNT5A, WNT3, WNT4 and WNT7A genes in ovaries from women with PCOS and from healthy women. While APC and β-catenin expression levels were similar in the oocytes of both patients and controls, conversely, WNT1 and GSK3β genes both showed elevated expression in the oocytes of patients with PCOS, therefore suggesting an association between aberrant expression of WNT1 and GSK3β and the pathogenesis of PCOS. The observations of the current study could be helpful to provide evidence regarding the pathogenesis of PCOS and its treatment.
Authenticity Occurs More Often Than Inauthenticity in Everyday Life
Authors: Huber Carolin , Germar Markus , Mojzisch Andreas
Published: March 2022

Abstract. Researchers have assumed that people generally strive toward authenticity, yet have also argued that authenticity may often be impeded by social constraints. Against this backdrop, it is unclear whether people feel authentic or inauthentic more often in everyday life. To address this question, we examined the retrospective frequency of these feelings. As researchers have conceptualized authenticity and inauthenticity in various ways, we also tested for generalization of the results across different conceptualizations. Our results indicate that authenticity occurs more often than inauthenticity in everyday life. While the results largely generalized across different conceptualizations of authenticity and inauthenticity, there was nonetheless some variation. Future research, therefore, should take different conceptualizations of authenticity and inauthenticity more into account.
Retrieval of Tropospheric Water Vapor From Airborne Far‐Infrared Measurements: A Case Study
Authors: Warwick L. , Brindley H. , Di Roma A. , Fox S. , Havemann S. , Murray J. , Oetjen H. , Price H. C. , Schüttemeyer D. , Sgheri L. , Tiddeman D. A.
Published: March 2022

We describe studies undertaken in support of the Far‐infrared Outgoing Radiation Understanding and Monitoring mission, European Space Agency's ninth Earth Explorer, designed to investigate whether airborne observations of far‐infrared radiances can provide beneficial information on mid and upper tropospheric water vapor concentrations. Initially we perform a joint temperature and water vapor retrieval and show that the water vapor retrieval exploiting far‐infrared measurements from the Tropospheric Airborne Fourier Transform Spectrometer (TAFTS) shows improvement over the a‐priori Unified Model global forecast when compared to in situ dropsonde measurements. For this case the improvement is particularly noticeable in the mid‐upper troposphere. Equivalent retrievals using mid‐infrared radiances measured by the Airborne Research Interferometer Evaluation System (ARIES) show much reduced performance, with the degrees of freedom for signal (DFS), reduced by a factor of almost 2. Further sensitivity studies show that this advantage is decreased, but still present when the spectral resolution of the TAFTS measurements is reduced to match that of ARIES. The beneficial role of the far infrared for this case is further confirmed by performing water vapor only retrievals using ARIES and TAFTS individually, and then in combination. We find that the combined retrieval has a DFS value of 6.7 for water vapor, marginally larger than that obtained for the TAFTS retrieval and almost twice as large as that obtained for ARIES. These results provide observational support of theoretical studies highlighting the potential improvement that far‐infrared observations could bring for the retrieval of tropospheric water vapor.
Wildfires Will Worsen, Warns U.N. Report
Authors: Rodrigues Meghie
Published: March 2022

From the equator to the Arctic, wildfires are likely to increase, and climate change can make them worse, according to a new United Nations report. Action is still possible, say the authors.
Insights Into Magma Storage Beneath a Frequently Erupting Arc Volcano (Villarrica, Chile) From Unsupervised Machine Learning Analysis of Mineral Compositions
Authors: Boschetty Felix O. , Ferguson David J. , Cortés Joaquín A. , Morgado Eduardo , Ebmeier Susanna K. , Morgan Daniel J. , Romero Jorge E. , Silva Parejas Carolina
Published: March 2022

A key method to investigate magma dynamics is the analysis of the crystal cargoes carried by erupted magmas. These cargoes may comprise crystals that crystallize in different parts of the magmatic system (throughout the crust) and/or at different times. While an individual eruption likely provides a partial view of the subvolcanic plumbing system, compiling data from multiple eruptions can build a picture of a whole magmatic system. In this study, we use machine learning techniques to analyze a large (>2,000) compilation of mineral compositions from a highly active arc volcano: Villarrica, Chile. Villarrica's postglacial eruptive activity (14 ka–present) displays large variation in eruptive style (mafic ignimbrites to Hawaiian style effusive eruptions), yet its eruptive products have a near constant basalt‐basaltic andesite bulk‐rock composition. What therefore, is driving explosive eruptions at Villarrica and can differences in storage dynamics be related to eruptive style? Here, we use a hierarchical cluster analysis to detect previously unseen structure in the composition of olivine, plagioclase and clinopyroxene crystals erupted at Villarrica, revealing the presence of compositionally distinct clusters within each crystal population. Using rhyolite‐MELTS thermodynamic modeling, we related these clusters to intensive magmatic variables: temperature, pressure, water content, and oxygen fugacity. Our results provide evidence for the existence of multiple discrete (spatial and temporal) magma reservoirs beneath Villarrica where melts differentiate and mix with incoming more primitive magma. The compositional diversity within an erupted crystal cargo strongly correlates with eruptive intensity, and we postulate that mixing between primitive and differentiated magma drives explosive activity at Villarrica.
Atmospheric Forcing of the Pacific Meridional Mode: Tropical Pacific‐Driven Versus Internal Variability
Authors: Zhang Yu , Yu Shi‐Yun , Amaya Dillon J. , Kosaka Yu , Stuecker Malte F. , Yang Jun‐Chao , Lin Xiaopei , Fan Lei
Published: March 2022

The Pacific Meridional Mode (PMM) impacts tropical Pacific sea surface temperature variations, which in turn affect the PMM through the excited atmospheric teleconnections. Previous studies linked this loop to the tropical Pacific‐excited North Pacific Oscillation (NPO; the second empirical mode of North Pacific sea level pressure variability), while a recent study proposed the linkage to the excited Aleutian low (AL) variability (the first empirical mode). Unraveling their relative importance for the loop is thus crucial for better understanding subtropical‐tropical interactions. Here, using tropical Pacific pacemaker experiments we show that tropical Pacific‐forced AL variability is tied to the loop, while the tropical Pacific‐forced NPO does not effectively induce PMM variability, hence not being in the loop. Our study emphasizes the role of tropical Pacific‐forced AL variability in the PMM‐tropical Pacific interaction, which should be paid more attention in future studies.
Electrical Conductivity of KCl‐H2O Fluids in the Crust and Lithospheric Mantle
Authors: Vlasov K. , Keppler H.
Published: March 2022

Evidence from diamond inclusions suggests that KCl‐bearing fluids may be abundant in the subcratonic mantle and these fluids may also cause local anomalies of high electrical conductivity. We therefore measured the electrical conductivity of aqueous fluids containing 6.96, 0.74 and 0.075 wt% KCl using a hydrothermal diamond anvil cell to 2.5 GPa and 675°C, and with a piston‐cylinder apparatus to 5 GPa and 900°C. We found that below 550°C, increasing pressure generally decreases solution conductivity, while at higher temperatures the effect is opposite. However, at high pressures, the conductivity of KCl in H2O is smaller than for NaCl, possibly due to a hydration shell collapse. The experimental data are described by two numerical models. The first model (R2 = 0.999), is preferable for crustal conditions: log σ = −2.03 + 25.0 × T−1 + 0.923 × log c + 0.990 × log ρ + log Λ0, where σ is the conductivity in S/m, T is temperature in K, c is KCl concentration in wt%, ρ is the density of pure water (in g/cm3) at given pressure and temperature. Λ0 is the limiting molar conductivity of KCl (in S·cm2·mol−1): Λ0 = 1,377 – 1,082 × ρ + 6,883 × 102 × T−1 – 2,471 × 105 × T−2. The second model (R2 = 0.986), is applicable to the lithospheric mantle: log σ = −1.52 – 357 × T−1 + 0.865 × log c + 1.72 × log ρ + log Λ0, with the same equation for Λ0. The latter model shows that already traces of KCl‐bearing aqueous fluid may account for high conductivity anomalies in the subcratonic mantle.