bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of Sedative activity of Cannabis Sativa in mice
Authors: Okenwa Samuel , Nwachukwu Jane Chidera , Ezeala Chisom Peace , Eze Ifeanyi , Onyioha Emmanuel Buchi , Amarachi Nnamdi Umuokeke , Okorie Austine Nkemakolam , Ejike Lazarus Chukwuemeka , Ihechukwu Uzoigwe Delight
Published: November 2024

Background: Cannabis sativa Linn. (Family: Cannabaceae) is commonly cultivated in Bangladesh in moist areas such as riverbanks, lakes, canals, and roadsides. The leaves of this plant are traditionally used to treat insomnia, depression, and neurodegenerative diseases. 
Objective: The study's objective is to investigate the sedative effects and phytochemical composition of the Cannabis sativa species in Nigeria.
Methods: The elevated plus maze was used to assess the sedative effect of various fractions of aqueous methanol extracts of Cannabis sativa at a dosage of 100 mg/kg in mice. Comparisons were made between the sedative action of the extract and diazepam, which was used as the positive control. Additionally, acute toxicity was also evaluated during the assessment.
Results: During the elevated plus-maze test, various parameters such as the number of entries in open arms and the number of entries in closed arms were recorded. The administration of different fractions of aqueous methanol extracts of Cannabis sativa resulted in a significant increase (p < 0.001) in the time spent in and the number of entries into open arms compared to the control group.
Conclusion: The findings suggest that various concentrations of water-methanol extracts from Cannabis sativa exhibit sedative effects that are superior to those of the control (diazepam), supporting the use of this plant in traditional medicine. Further research should be conducted to investigate the active components of Cannabis sativa and understand the mechanism of its effects before proceeding to clinical trials.
Phenotypic Trait Analysis of Tomato (Solanum lysopersicum) Genotypes in Qatar and Indian Agro-climatic Conditions
Authors: Khan Muvin , Garg Amar Prakash
Published: November 2024

Background: The study included four genotypes of tomato (EC620378, EC620380, EC620383, EC620534) which were cultivated to find out their similarities and differences based on phenotypic traits when they were grown under different soil zones of Doha (Qatar) and Meerut (India) to find out that which of the genotypes can be cultivated better in Qatar and India. Methods: The experiment was laid out in Randomized Complete Block Design (RBCD) with two replications. Statistical analysis for variation in quantitative characteristics among genotypes was done by collecting data in 15 qualitative and quantitative traits. Data showed great variation for almost all the traits. The principal component analysis involved plant height and days to marketable maturity as the most discriminating trait that accounted for greater variability in genotypes in both zones, and they should be considered in tomato improvement programs. The correlation analysis showed that fruit yield per plant was positively and significantly correlated with number of fruits per plant and fruit width. Present findings suggest that the identified superior genotypes may be utilized by different farms to further improve their breeding and cultivation strategies. Result: In Indian soil zone, genotype EC620534 performed extremely well in terms of maximum yield per plant. Similarly, in Qatar soil zone, EC620534 and EC620380 performed well. The phenotypic coefficient of variation (PCV) was higher than its corresponding genotypic counterpart (GCV) for all characters studied showing environmental influence. High broad-sense heritability were recorded for days to marketable maturity, fruit shape index and fruit weight in both agro-climatic zones, they were associated with low genetic advance indicating non-additive gene action and environmental influence, hence, heterosis breeding is recommended.
Performances and Rituals for Environmental Campaigns: Structures, Discourses, and Postcolonial Ecocriticism
Authors: Setiawan Ikwan , Suwargono Eko , Zamroni Muhammad , Suharto  , Hartanto Denny Antyo
Published: November 2024

This paper discusses some performing arts and rituals that carry the environmental theme in Jember. Artists and village governments respond creatively to environmental problems by creating several multi-form events, combining performances and certain rituals. We will use postcolonial ecocriticism as a theoretical framework to discuss some of their produced show events. Postcolonial ecocriticism emphasizes analysis to reveal how cultural texts present current ecological problems as a legacy of colonialism in aesthetic works that can function as advocacy and activism. The results of this study show that the performances and rituals develop critical awareness regarding environmental threats and problems in Jember and Indonesia. They bring the topic of the environment to invite the community to jointly maintain the sustainability of the human environment and criticize government policies to legitimize the destruction of nature in the name of development.
Historical and Religious Site as Tourism Attraction: The Case of the Demak Great Mosque
Authors: Susilowati Indah , Ayu Kusumawardhani Hapsari , Wardhani Arisanti Ayu , Islam Gazi Md Nurul , Febrianti Anisa Millenia , Pungkasa Yeremia Satrya
Published: November 2024

Historical and religious sites are developing into tourist attractions. Tourist perception is interpreted as one way to determine visitor satisfaction, can advance the improvement of tourist attractions, and is a driver for revisit intentions. This study aims to explore the views of tourists regarding the meaning of the religious and historical as a tourist attraction, the pattern of visitor density in the tourist area of the Great Mosque of Demak, and to identify the perception of tourists about facilities, and revisit the intention of the Demak Great Mosque. The photovoice method is used to answer the meaning of Demak Great Mosque visitors from November to December 2022. The participants in the photovoice method were 12. The second method is the descriptive quantitative to answer objectives 2 and 3. The sample of this study was 104 respondents. All the tourist respondents collected multistage sampling. The results of this study indicate that the Demak Great Mosque is an attraction for historical, religious and educational tourism. In the tourist object area, the Great Mosque of Demak has the highest density in the high and low seasons. Tourist perceptions of the quality of religious and non-religious facilities. This means that the Great Mosque of Demak already has a capacity for facilities that satisfy visitors. The mosque's architecture attracted the majority of tourists and least of all, they consider the lack of shelter from the hot sun. The intention of visitors to return to the Great Mosque of Demak is 89.42%.
ÇİNGENE MİTOLOJİSİNİN MODERN BİR ANLATISI: YERE DÜŞEN DUALAR
Authors: Sürücü Özlem
Published: November 2024

Mitolojik anlatılara ait unsurların güncel edebiyatta yeniden görünüm kazanması, postmodernizmin açtığı yolla gerçekleşir. Çağdaş Türk edebiyatının adından söz ettiren yazarlarından biri olan Sema Kaygusuz, Yere Düşen Dualar adlı romanını mitolojik öğelerle örmüştür. Postmodern bir anlayışla yazılmış olan bu eserde Çingene mitolojisinin belli başlı varlıkları ve unsurları metinlerarası bağlamda yeni kurgularla metne dâhil edilmiştir. Söz konusu kurgularda kimi zaman mitolojik bir karakterin yalnızca ismini ödünç alan Kaygusuz, kimi zaman mitolojik bir unsuru bağlamından kopararak farklı olay örgüleriyle esere taşımıştır. Bazen de aynı isimle yarattığı karakterleri mitolojik arka plana sadık kalarak işlemiş, bunu yaparken de okuru bizzat Çingene mitolojisine yönlendirmiştir. Bu çalışmada Yere Düşen Dualar adlı romanda Çingene mitolojisinin metinlerarası bağlamda işlenişi, mitolojik varlıklar ve unsurların incelemesiyle birlikte verilecektir.
HOST COUNTRY LANGUAGE ACQUISITION AMONG FIRST-GENERATION YAGLIDERE IMMIGRANTS IN THE USA AND THE MAINTENANCE OF THE TURKISH LANGUAGE IN SUCCESSIVE GENERATIONS VIA SOCIAL NETWORKS
Authors: Yalçın Özcan Emine , Massey Douglass,s
Published: November 2024

This article investigated the effect of the social networks of Yaglidere Turkish immigrants on language acquisition and the maintenance of heritage languages by successive generations in the USA. The study was conducted in the cities of Patterson and Burlington between January 2018 and July 2018. This research used qualitative research methods to analyze ethnographic interviews and participant observations. Data were collected using participant observation and informal talks with immigrants conducted in different informal settings such as participants’ houses, their restaurants, and other cafes in Burlington and Paterson. The interviews lasted from 40 to 90 minutes. Questions were open-ended and focused on the role of social networks in the acquisition of English language skills. In order to analyze the resulting data, the audio recordings were transcribed and translated into English. The interviews were first transcribed into Microsoft Word files and then imported into Maxqda, a software program for qualitative analysis, where the data were coded for study. The results indicated that even though social networks have destructive effects among first-generation immigrants, they have undeniable constructive effects on language maintenance in other generations. So, what is destructive for the first generation turns into constructive for the other generations.
ANADOLU SELÇUKLU MİMARİSİNDE TAŞÇI İŞARETLERİ: İNCİR HANI ÖRNEĞİ
Authors: Bilgin Ali Riza
Published: November 2024

Öz: Taşı yontan kişinin kimliğini belirten işaretler ve taşın kullanılacağı yeri gösteren işaretler olarak iki grup altında toplanan taşçı işaretlerinin Antik dönem ve Avrupa Orta Çağ mimarilerindeki kullanım amaçları kısmen de olsa aydınlatılmış ve yapıların inşa süreçlerine ilişkin önemli veriler sunabilecekleri kanıtlanmıştır. Anadolu Selçuklu dönemi mimarisinde de sıklıkla kullanıldığı anlaşılan taşçı işaretleri, dönem mimarisinin inşa sürecine ilişkin bilinmezlere ışık tutma potansiyeline sahip olmasına rağmen Anadolu Türk mimarisi literatüründe yeterli düzeyde yer bulamadığı için bilinmezliğini korumaktadır. Burdur’un Bucak ilçesinde bulunan ve II. Gıyaseddin Keyhusrev döneminin önemli yapılarından olan İncir Hanı da literatürde pek çok kez konu edinilmiş olmasına rağmen yapıda bulunan taşçı işaretleri kayıt altına alınmamıştır. Yapılan bu çalışmada İncir Hanı dışında başka yapılarda da saha çalışmalarıyla kayıt altına alınan işaretler ile mevcut literatürde belgelenmiş taşçı işaretleri bir araya getirilmiş, İncir Hanı’ndaki taşçı işaretleriyle kıyaslanarak yapının inşa süreci ve Anadolu Türk mimarisinde taşçı işaretlerinin mahiyeti hakkında değerlendirme yapılmıştır.

Anahtar Kelimeler: Anadolu Selçuklu Mimarisi, Taşçı İşaretleri, Kervansaray, Orta Çağ Mimarisi, II. Gıyaseddin Keyhusrev.

An Analysis of Stonecutters' Marks in Anatolian Seljuk Architecture: A Case Study of İncir Han

Abstract: Despite their potential to illuminate construction processes and elucidate details of historical craftsmanship, stonemason's marks remain understudied within the field of Anatolian Turkish architecture. While research on ancient and European medieval architecture has partially unveiled the purposes and significance of these marks, their application in Anatolian Seljuk contexts specifically needs further investigation. This paper argues that by analyzing stonemason's marks, we can unlock valuable insights into the construction techniques and organization employed during this key period. We focus on İncir Han, a prominent Seljuk structure in Burdur's Bucak district, which, despite receiving some scholarly attention, has had its stonemason's marks largely overlooked. Drawing on both our own field studies at İncir Han and existing literature documenting marks in other Anatolian Seljuk buildings, we aim to: Identify and catalog the stonemason's marks present in İncir Han; Compare these marks with those found in other Anatolian Seljuk structures; Analyze the potential implications of these marks for understanding the construction process of İncir Han and, by extension, broader Seljuk architectural practices. Through this comparative analysis, we hope to contribute to a richer understanding of stonemason's marks within Anatolian Turkish architecture, highlighting their potential as a valuable source of information for future research and architectural restoration efforts.

Keywords: Anatolian Seljuk Architecture, Stonecutters’ Marks, Caravanserai, Medieval Architecture, Gıyaseddin Keyhusrev II.
SOSYAL PROBLEMLER SOSYOLOJİSİ PERSPEKTİFİNDEN TÜRKİYE’DE BEYİN GÖÇÜ
Authors: Taşcı Cansu
Published: November 2024

Beyin göçü, son yıllarda tüm dünyanın en çok tartıştığı meselelerdendir. Beyin göçü yeni bir olgu olmamakla birlikte konunun dünya gündeminde yer alması 1960’lı yıllar itibariyle gerçekleşmiştir. Beyin göçü gelişmiş bir ülkeden bir başka gelişmiş ülkeye gerçekleşebileceği gibi genellikle az gelişmiş/gelişmekte olan ülkelerden gelişmiş ülkelere gerçekleşmektedir. Gelişmiş ülkelere beyin gücü ihraç eden gelişmekte olan birisi de Türkiye’dir. Beyin göçü olgusu son yıllarda hem medya organlarında hem de siyaset arenasında bir “problem” olarak sıkça tartışılmaktadır. Bu makalenin amacı beyin göçü olgusunun Türkiye için bir sosyal problem olup olmadığı meselesini sosyal problemler perspektifinden incelemektir. Bu makalede Türkiye’de “beyin göçü” olgusunun tarihsel süreç içerisinde iddia sahipleri tarafından sosyal bir problem olarak inşa edildiği sürece odaklanılmaktadır. Bu bağlamda Spector ve Kitsuse’nin ortaya koymuş olduğu 4 ana aşama üzerinden Türkiye’de beyin göçü olgusunun sosyal bir problem olarak inşa süreci ele alınmıştır. Bu kapsamda doküman incelemesi ve içerik analizi tekniğiyle gazete haberlerinden elde edilen verilerden yararlanılmıştır. Analiz sonucunda tarihsel süreç içerisinde beyin göçünün problem olarak tanımlanmasında iddia sahibi olarak iki aktörün- bilim insanları ve siyasetçilerin- kritik rol oynadığı, konunun özellikle sosyal, ekonomik ve politik kriz dönemlerinde bir problem olarak gündeme geldiği görülmüştür.
VİDİN MUHAFIZI VEZİR KARA MEHMET PAŞA’NIN HAYATI, MÜSADERE SÜRECİ VE SERVETİNİN ANALİZİ
Authors: Üzden Anıl
Published: November 2024

Osmanlı Devleti 1699 Karlofça Antlaşması ile önce “kaybettiği toprakları geri alma”, 1718 Pasarofça Antlaşması sonrasında ise “sınırlarını savunmaya yönelik” politikalar izlemeye başlamıştır. Belgelerde, “darü’l-cihad ve’l-mücahidin” olarak anılan ve XVIII. yüzyılda bir serhat şehrine dönüşen Vidin’de bu adımların örneklerini izlemek mümkündür. Vezir Kara Mehmet Paşa devletin çok çeşitli bölgelerinde görev yapmış, son olarak Vidin Kalesi’ne muhafız olarak tayin edilmiştir. Vezir Kara Mehmet Paşa’nın hayatı, müsadere süreci, ilişkiler ağı ve muhallefatının değerlendirilmesi bu çalışmanın temel amacını teşkil etmektedir. Bir bürokratın görev yaptığı bölgelerde mekâna etkisi ile özel ve kamusal alandaki yaşam tarzı tarihsel bağlamda incelenmiştir. Bu kapsamda üst düzey bir yönetici özelinde XVIII. yüzyıl Osmanlı Devleti’nin sosyal, ekonomik ve kültürel tarihine dair çıkarımlarda bulunulmuştur. Çalışmada; araştırma ve inceleme eserlerin yanında Cumhurbaşkanlığı Osmanlı Arşivi Bâb-ı Defterî Başmuhasebe Muhallefat Halifeliği fonundaki ve Topkapı Sarayı Müzesi Arşivi’ndeki defter ve evraklar ile Vidin Şerʽiyye sicillerinden yararlanılmıştır.
HOKAND- BUHARA TİCARİ MÜNASEBETLERİ (1840-1876)
Authors: Kılıçaslan Yusuf
Published: November 2024

Öz: Hokand Hanlığı ile Buhara Emirliği komşu diğer devletler (Hindistan, Rus ve Mançu İmparatorluğu, Hive Hanlığı gibi) ile de ticari münasebetler kurmuşlardır. Ancak coğrafyayı göz önünde bulundurduğumuz zaman tüm bu ülkeler ile yapılan ticarette bu iki Türk devleti birbirine bağımlıdır. Zira doğu yönlü ticaret yapmak isteyen Buharalı tüccarlar Hokand Hanlığı sınırlarından, Batı ve Güney yönlü ticaret yapmak isteyen Hokandlı tüccarlar ise Buhara Emirliği topraklarını kullanmak zorundadır. Tüm bu ismi zikredilen devletlerin birbirleriyle olan ticareti bu çalışmanın çok uzağındadır. Dolayısıyla çalışma Buhara Emirliği ve Hokand Hanlığı arasında gerçekleşen ticari faaliyetleri ele almaktadır. Özellikle Rus işgalinden evvel kaynaklarda yeterli bilgi olmayışı konunun tarih aralığını Hokand Hanlığının son dönemleri ile sınırlamamızı elzem kılmıştır. Geriye dönük bilgilerin ise hemen tamamı gezginlerin seyahat notlarından ve Rus kaynaklarından takip edilebilmektedir. Kaynaklarda yer alan malumatlara göre ticari faaliyetlerin yoğunluğu göze çarpmaktadır. İki devlet arasında tüccarlar vasıtasıyla alınıp satılan ticaret malları bölge ahalisinin geçim kaynaklarının başında gelmektedir. Tarımsal-hayvansal ürünler, ipek, kâğıt, kumaş ve el işçiliği ürünler Hokand ve Buhara pazarlarında önemli paya sahiptir.
Anahtar Kelimeler: Buhara, Hokand, Ticaret, Ruslar, İpek.
DEDE KORKUT OĞUZNAMELERİ ÜZERİNE: BAMSI BEYREK BOYUNA AİT BİR SOYLAMA ÜZERİNE
Authors: Ağca Ferruh
Published: November 2024

Öz: Bu makalede, Dede Korkut Oğuznamelerinin Dresden nüshasında geçen Bamsı Beyrek Boyu’na ait bir soylama ve soylamada problemli olan bazı hususlar, yeni bulunan Bursa yazmasındaki tanıkların yardımıyla ele alınıp değerlendirilmiştir. Dresden nüshasına dayalı daha önceki metin yayımlarında okunuşu ve buna bağlı anlamlandırılışı çözümsüz kalmış ya da ileri sürülen okumaların şüpheli olduğu, buna istinaden yeniden çözümlemek için ayrıca yazıların yazıldığı soylamadaki problemli hususlar, Bursa yazmasında hareke sisteminden dolayı daha açıktır. Bu makalede, Bamsı Beyrek Boyu’ndaki soylamanın Dresden nüshasında geçtiği satırlar verilmiş, önceki çalışmalarda kabul edilen okumalar ve anlamlandırmalara dair literatür değerlendirilmiş, ardından da soylama Bursa yazmasına göre tekrar okunmuştur. Böylece Bamsı Beyrek Boyu’nun Bursa yazmasındaki ilgili soylama, daha önce Dresden nüshası için teklif edilen okuyuşları da düzeltmekte, buna göre Dresden nüshasında nasıl okunması gerektiğini ortaya koymaktadır. Makalede, soylamada geçen sözcükler ve ibareler, tarihsel ve modern Türk yazı dillerindeki tanıklarla söz varlığı açısından ve anlam bilimsel olarak yorumlanmış ve bir sonuca ulaşılmaya çalışılmıştır.
Anahtar Kelimeler: Dede Korkut Oğuznameleri, Bamsı Beyrek Boyu, Bursa yazması, soylama, anlam bilim.
Agri-food fraud in Africa vis-à-vis global health
Authors: Abia Wilfred Angie , Perkwang Taty Brandy , Djoussou Kaoke Matheiu
Published: November 2024

This paper reports on the extent of agri-food fraud in Africa, its occurrence across the Africa-EU trade borders, and associated implications for global health. It revealed that agri-food fraud in Africa and across Africa-EU trade borders may be a concern. Meanwhile, a few suspected cases have been reported, there may be more unchecked/unnoticed agri-food fraud practices ongoing in Africa requiring food trade border checks and rapid decisions making processes to reduce exposures. Exposure to adulterants can have significant implications for global health, as consumers unknowingly pay for, and consume, products that may be adulterated with substances which constitute a risk factor to one or more unchecked hazards against consumers' health protection. As global trade in agri-food products expands, the supply chain vulnerability to fraudulent activities becomes increasingly evident. This may be worse partly due to the inadequate food safety laws in African countries or poor enforcement. There is a need for food safety regulations in Africa that aim to ensure the safety and authenticity of food products, protect public health, and maintain consumer confidence. Finally, there is a need for rapid detection tools to make quick decisions on the field and agri-food traceability systems.
External debt and economic growth: A study from the perspective of developing and emerging economies
Authors: Abbas Shehzada Ghulam
Published: November 2024

This study explores the relationship between economic growth and external debt for 24 highly indebted developing and 21 highly indebted emerging economies. This study uses data from 2010 to 2019  and a dynamic panel data model-Generalize Methods of Moments (GMM) to investigate the relationship. The study found that external debt significantly and adversely impacts economic growth for the sample of 24 developing countries indicating external debt being one of the major determinants of economic growth for developing countries whereas it is negative but insignificant in the case of 21 emerging economies showing no impact of external debt on economic growth in the case of emerging economies. This study also found a significant and positive relationship between gross capital formation (GCF) and lag of GDP growth (GDPgr) and economic growth for both developing and emerging economies. Inflation has no significant impact on economic growth in the case of developing countries whereas it has a significant and negative impact on economic growth for the sample of emerging economies. Trade openness has no significant impact on economic growth for data samples. In addition, the long-run estimates show a negative relationship between external debt and GDP growth for both groups of countries. The results imply that targeted and efficient debt management and using traditional alternatives (i.e., tax revenue mobilization and domestic borrowing) should be prioritized for both countries.
Exchange rate innovation, global pandemic and stock market returns: Empirical evidence from ECOWAS countries
Authors: Omeje Ambrose Nnaemeka , Chukwu Ndubuisi Obeka , Mba Augustine Jideofor
Published: November 2024

This study used the panel VAR impulse response function model and high-frequency monthly data from 2020M1 to 2021M12 to examine the response of innovations in the exchange rate and stock market returns to the COVID-19 pandemic in Economic Communities of West African States (ECOWAS). The study found that the effect of shocks of COVID-19 today on future exchange rate innovation worsens the real conditions of exchange rate innovation in ECOWAS countries. Again, the impact of the shocks of COVID-19 today on future stock market returns encourages the real conditions of stock market returns in ECOWAS countries. It was recommended that instead of lockdown, ECOWAS governments should explore other policy options peculiar to the region in COVID-19 containment and also strive harder to deepen the stock market and encourage increased utilization of information and communication technology in stock market trading to cut costs, raise returns and connect trade with the rest of the world’s stock markets.
Ethnographic lens: Understanding managerial and operational level perspectives on ESP teachers roles
Authors: Poedjiastutie Dwi , Masduki  , Mayaputri Velmi
Published: November 2024

This study investigates the managerial level (the deans of the faculties and the director of ESP) perspectives and ESP teachers’ perspectives (operational level) on how they assume their roles in teaching ESP. This study used an ethnographic approach. The phenomena of an    ethnography are commonly examined from a collective perspective. This suggests analyzing the culture under investigation from an insider's viewpoint by emphasizing the significance that the members of  that society attribute to it. The findings show that sociocultural factors are assumed to influence the deans’ expectations of what teachers must do in comparison to what teachers themselves should be doing. ESP teachers at the operational level assume their roles in teaching and   learning ESP as motivation builders, classroom controllers, teaching strategy innovators and lifelong learners. Meanwhile, the deans of the faculty’s (managerial level) expectations of ESP teacher roles entail a material developer, a curriculum contributor, a language trainer, a student mental safeguarding, a collaborator and a program evaluator. While deans and teachers share a common goal of educating students, their roles, responsibilities and perspectives differ significantly leading to different expectations. Both cohorts namely managerial level and ESP teachers should intensively discuss to obtain a satisfactory agreement in executing roles and responsibilities. Besides, when designing professional development, it is suggested to focus on two areas: enhancing and sustaining instructors' English proficiency and expanding language teaching knowledge and skills.
Development of a creative digital curriculum for the elderly: A participatory approach to enhance potential for alternative career opportunities in the digital era
Authors: Saisee Parit , Supachant Sukontip , Patthanaphong Omthong , Limphaiboon Jaruwan , Fongkanta Pongwat
Published: November 2024

This research aimed to develop a curriculum for empowering the elderly to create alternative careers in the digital society era through digital platforms and to study the effects of the curriculum and online educational channels on enhancing the elderly’s capabilities. Participatory Action Research (PAR) methods combined with qualitative and quantitative approaches were employed in this study. The study involved 555 participants including personnel and elderly individuals in Lampang Province that were selected by using multi-stage sampling. Descriptive statistics were used to analyze the data and compare the group mean by t-test. The research findings revealed that the “Creative Digital Retirees” curriculum for empowering the elderly to use digital technology, digital media literacy and utilizing digital media to create alternative careers met the effective criteria, the 80/80 efficiency criteria with E1 = 80.00 and E2 = 87.16. The effective curriculum consists of five learning units including Unit 1: Using technology media for the elderly, Unit 2: Understanding and digital literacy for the elderly, Unit 3: Creating social media for the elderly, Unit 4: Accessing, efficient use of technology and technology management for the elderly, and Unit 5: Electronic law. The elderly’s capabilities significantly improved at a significance level of 0.05. For curriculum users’ satisfaction, the result showed the highest level of satisfaction with an average score of 4.59. It is concluded that the curriculum is effective and can genuinely enhance the elderly’s learning achievements.
Possible treatments for synchronous bilateral small renal masses
Authors: Pecoraro Angela , Diana Pietro
Published: November 2024

Currently, there is no established consensus on the best treatment approach for patients with bilateral synchronous renal masses (BSRM). The timing and method of managing these cases remain subjects of debate. This review aims to summarize the available literature and explore the ongoing controversies surrounding this topic. Three studies investigated non-surgical treatments within BSRM. Specifically, one study focused on active surveillance (AS) and showed no statistical differences in terms of progression and development of metastatic disease relative to their unilateral counterpart. Two studies investigated ablative techniques showing promising results. Eight papers have been published regarding robot assisted partial nephrectomy (RAPN) for BSRM. All these papers highlighted the safety, feasibility, and efficacy of bilateral RAPN for BSRM. Literature regarding treatments other than surgery such as AS and ablative therapies (ATs) for BSRM is scarce, but promising. Progression, rate of metastases and survival of BSRM are similar to unilateral disease, and AS is a safe option in these cases. Few studies focused on RAPN related outcomes for BSRMs, but all confirmed the safety, feasibility, and efficacy of this procedure. Finally, one step RAPN resulted as feasible as the two staged procedures, especially when selective clamping techniques can be chosen.
Exploring carbon emission effects of national-level industrial park policies on cities in China
Authors: Hu Xiaru , Zhang Yuquan W. , Geng Yong , Yu Haishan , Li Linfeng
Published: November 2024

Serving as the backbone of economic development, industrial parks have strong implications for reducing carbon emissions in China under the “carbon peak and carbon neutrality” background. This study explores the carbon emission reduction effects of three different types of national-level industrial parks on prefectural-level cities in China, including economic and technological development zones (ETDZs), eco-industrial demonstration parks (EIDPs), and low-carbon industrial parks (LCIPs). Data on 204 prefectural-level cities over the period of 1999 to 2019 were examined by using the difference-in-differences method and the mediating effect model. The study revealed that (1) the three types of industrial parks significantly reduced the intensity of city carbon emissions by 1,155, 395, and 450 tons per million CNY, respectively; (2) There existed lag effects of 7 years for the ETDZ and 3 years for the EIDP; (3) Industrial structure exhibited significant mediating effects, with ETDZ and EIDP reducing city carbon emission intensity by 58 and 56 tons per million CNY, respectively; (4) Strong heterogeneity in the effects was found, arising from the differences in geographical location, resources endowment, and amount of industrial parks; and (5) ETDZ and EIDP reduced the carbon emission intensity of neighboring cities by 174 and 144 tons per million CNY, respectively, while LCIP increased that by 686 tons per million CNY. The major contribution of this study is analyzing the city-level impacts of ETDZ, EIDP, and LCIP, three different types of national industrial park policies with different implementation periods, regional distributions, and policy focuses. This not only fills a gap in the analyses of ETDZ and LCIP policies in this area of research, but also draws analogies and contrasts between the effects of the three different policies. This study suggests that the stability and long-term nature of industrial park policies be maintained and further transformation and upgrading of industrial structure be attained. Additionally, intercity coordination could be introduced or enhanced.
Combining Cre-LoxP and single-cell sequencing technologies: insights into the extracellular vesicle cargo transfer
Authors: Pfaffl Michael W.
Published: November 2024

The recent study from the Pogge von Strandmann group published in Cellular and Molecular Immunology , by Alashkar Alhamwe et al ., combined for the first time the Cre-LoxP recombination system with single-cell sequencing. The group monitored the tumor-derived extracellular vesicle (EV) uptake and the EV functions in the recipient non-malignant cells in a pancreatic ductal adenocarcinoma mouse model. Recombination events and EV uptake, together with resulting gene expression changes in macrophages, neutrophils, and mast cells, were detected by single-cell sequencing technology of the tumor tissue. This new approach is highly specific, as it can identify single EV recipient cells without interfering with the EV biogenesis or the phenotype.
Study on the Overseas Reader Reviews of English Translation of Sanguo Yanyi
Authors: Fan Chiqi , Wang Yuxuan , Lin Xiang , Wang Juan
Published: November 2024

Reader evaluation is a key step in measuring the effectiveness of literary translations. A thorough investigation of the reception of Chinese classical novels among overseas readers can help us understand Western readers’ acceptance, value judgments, and preferences regarding these works. This study aims to assess the translation quality and value of the English version of Sanguo Yanyi by Yu Sumei. By collecting reader reviews from platforms such as Amazon and Goodreads, we employ KHCoder text analysis software to generate visualizations that analyze reader feedback. The results indicate that several main factors influence reader evaluations of this translation, including translation quality, English language experience, narrative coherence, and overall reading experience. Therefore, Chinese translators should comprehensively consider the needs and reading habits of overseas readers when translating classical Chinese novels.
Designações para pipa sem varetas na região do falar amazônico: um estudo com dados do projeto ALiB
Authors: Saraiva Danyelle Almeida
Published: November 2024

Este trabalho analisa as designações para pipa sem varetas a partir de dados extraídos da dissertação O falar amazônico: uma análise da proposta de Nascentes (1953) a partir de dados do projeto ALiB (Portilho, 2013), que utilizou dados geolinguísticos do Projeto ALiB em 26 localidades das regiões Norte, Nordeste e Centro-Oeste, com o objetivo de visualizar se há uma marca dialetal própria da região do falar amazônico, proposta por Nascentes (1953), no que se refere ao nível lexical. Para isso, foram utilizados procedimentos teórico-metodológicos da Dialetologia, da Geolinguística e da Lexicologia, com a finalidade de verificar se a designação curica, mais produtiva na região analisada, seria uma possível marca dialetal própria da região em foco, influenciando a norma linguística da área de controle no que se refere ao nível lexical da língua, especificamente na área semântica de jogos e diversões infantis.
A configuração discursiva exuzesca em Jorge Amado: linguagem encruzilhada
Authors: Ribeiro Leandro Lima
Published: November 2024

Examinam-se neste artigo os diferentes procedimentos de figurativização no romance Capitães da Areia, de Jorge Amado (1937), à luz da Semiótica discursiva de linha francesa, recorte do trabalho de Ribeiro (2022). A dispersão da figuratividade determina o horizonte sócio-histórico e ideológico do discurso; concretiza os esquemas semionarrativos e cria efeitos de realidade, iconicidade e novidade estética. Começa por examinar uma lógica de dupla estigmatização social dos sujeitos em situação de rua. Em seguida, mostra-se uma configuração discursiva exuzesca, mediada pela carnavalização e por equivalências semânticas entre Exu e os meninos em situação de rua. Nosso objetivo é discutir como esses elementos temático-figurativos perpassam uma dimensão religiosa assentada no Brasil-Terreiro.
A PRE-EXPERIMENTAL STUDY ON EFFECTIVENESS OF AWARENESS PROGRAM TOWARDS REDUCING STIGMA REGARDING MENTAL ILLNESS AMONG ASHA WORKERS AT SELECTED PHC OF SEPAHIJALA, TRIPURA
Authors: Saha Anamika , Sarkar Subhra
Published: November 2024

A pre-experimental study was conducted to assess the effectiveness of awareness program towards reducing stigma regarding mental illness among ASHA workers at selected PHC of Sepahijala, Tripura. A quantitative Pre-experimental research design was adopted by the researcher for conducting the study, and the Roys adaptation model was used as the framework. Data was collected from 30 ASHA workers after taking informed consent who were selected by non-probability purposive sampling technique through a self-structured stigma assessment scale. Obtained data was complied and analyzed according to objectives using frequency, percentage, mean, standard deviation, paired t test and chi square test. The findings of the study revealed that mean post test stigma score of ASHA workers were significantly higher than the mean pretest stigma score, which was significant at <0.05 level after exposure with awareness program. Therefore the awareness program was an effective method of imparting knowledge to ASHA workers.
SUSTAINABLE MATERIAL SOURCING IN THE FASHION SUPPLY CHAIN: CURRENT TRENDS AND FUTURE DIRECTIONS
Authors:   Faculty of Textiles, Engineering and Business, University of BorÃ¥s, BorÃ¥s, Sweden., Rahman Mizanur , Hassan Nazmul ,   Faculty of Textiles, Engineering and Business, University of BorÃ¥s, BorÃ¥s, Sweden.
Published: November 2024

This review article aims to find the increasing need to source materials that are sustainable to mitigate the effects on the environment, improve the social status, and adapt to the dynamic fashion consumer needs. Some of the main trends discussed in this work include the use of organic fibers, recycling fabrics and the introduction of new biodegradable textiles. The review article also further discusses the implication of certifications and standards in the issue of transparency and accountability. This paper analyses the broader environmental, social and economical root causes of sustainable sourcing which focus on the long term gains although possibly costly in the short run. Moreover, the article also points out the directions for future research comprising of technology advances in recycling, biofabrication techniques, status changes in frameworks and policies and trends in consumer behaviour that may potentially influence the sustainability of fashion.
GESTATIONAL DIABETES COMPLICATED FROM KETOACIDOSIS DURING FETAL LUNG MATURATION CORTICOSTEROID THERAPY. A CASE REPORT
Authors:   Gynecology-Obstetrics Service, Mohammed V Military Training Hospital, Rabat, Morocco., V. Nabalim Ivaldino , Lina Outrighet ,   Gynecology-Obstetrics Service, Mohammed V Military Training Hospital, Rabat, Morocco., Benali Saad ,   Gynecology-Obstetrics Service, Mohammed V Military Training Hospital, Rabat, Morocco., Ngendabayikwa Richard ,   Gynecology-Obstetrics Service, Mohammed V Military Training Hospital, Rabat, Morocco., Indami David ,   Gynecology-Obstetrics Service, Mohammed V Military Training Hospital, Rabat, Morocco., Balde Mamadou ,   Gynecology-Obstetrics Service, Mohammed V Military Training Hospital, Rabat, Morocco., Dembele Chaca ,   Gynecology-Obstetrics Service, Mohammed V Military Training Hospital, Rabat, Morocco., Kouach Jaoud ,   Gynecology-Obstetrics Service, Mohammed V Military Training Hospital, Rabat, Morocco.
Published: November 2024

Gestationaldiabetescomplicated by an acid-ketosisis a rare but serious complication, involving the life-threatening condition of the mother and fetus binomial, responsible for significantmaternal and fetalmortality. It is an acute metabolic emergency withmultidisciplinary management. Earlydiagnosis and treatment are critical to the life of the mother and fetus. We report the case of a 32-year-old womanwith 24 weeks of amenorrhea, without a personal or familyhistory of diabetes, carrying a recentlydiscoveredgestationaldiabetesunbalanced, wasadmitted to obstetric emergencies in a context of premature rupture of membranes. Shewastreatedwith a corticosteroid for fetallung maturation causing an acidketosis on gestationaldiabetes. Shereceivedinsulintherapy, rehydration and correction of herionicdisorders. Close monitoring wasmaintained for up to 36 weeks of amenorrhea, atwhich time itwastriggered and delivered via vaginal route withoutmaternal and fetal complications.
The role of choline in the physiology of reproductivity
Authors: Dikke G. B.
Published: November 2024

Choline is an essential nutrient, but intake among pregnant women is insufficient – only 7% of them consume adequate amounts of choline. The discrepancy between choline requirements and actual intake raises questions about the need for choline supplementation and its potential benefits for pregnant women. The diet of the expectant mother, rich in choline, in the preconception period ensures folliculogenesis and better quality of oocytes, changes the foetal epigenome, counteracting genomic defects during intrauterine development and reducing the susceptibility to metabolic changes in adulthood. Choline is a source of methyl groups and its consumption reduces the risk of NTDs by 7 times, so a promising trend in nutritional support of pregnancy and prevention of NTDs is the intake of folates and choline in combination with other micronutrients. Choline promotes the growth, proliferation and functioning of placental cells, transport of macronutrients, and has an anti-inflammatory effect. The risk of low foetal weight is reduced by 69% when choline is added to the mother’s regular diet. A significant connection has been shown between high levels of choline in the mother and a 2-fold reduction in the risk of preeclampsia, premature birth and a significant effect on the neurodevelopment and mental health of the child – improving neurocognitive functions and reducing the risk of autism and attention deficit hyperactivity disorder. A choline supplement at a dose of 130 mg/day as part of the vitamin-mineral complex Femibion 1 is sufficient to meet the needs for this nutrient during the preconception period and in the first trimester of pregnancy. The need for choline supplementation in the pregravid period and the first trimester of pregnancy is because on folliculogenesis and oocyte protection, epigenetic programming, the effectiveness of preventing congenital malformations of the foetus, participation in metabolic and physiological processes in the placenta, reducing the risk of placenta-associated complications, influence on the development of nervous tissue and brain of the foetus and newborn.
D-hypovitaminosis in menopausal disorders clinic: Correction possibilities
Authors: Izmozherova N. V. , Popov A. A. , Ryabinina A. V. , Vikhareva A. A.
Published: November 2024

Introduction. The postmenopausal period being a significant part of a modern woman’s life. The persistence of menopausal disorders clinic can be combined with the hypovitaminosis D state, which, in turn, can further aggravate the existing symptoms. Vitamin D supplementation may be one of the pharmacological approaches to correct menopausal disorders.

Aim. To evaluate the contribution of hypovitaminosis D to the clinic of menopausal disorders; to determine the clinical efficacy of using cholecalciferol in late postmenopausal residents of Yekaterinburg.

Materials and methods. During the period from 2018 to 2021, 144 late postmenopausal patients from 56 to 79 years old living in Yekaterinburg and do not need outside help in everyday life took part. The following parameters of anthropometry, the severity of modified menopausal index (MMI), hospital anxiety and depression scales (HADS), Mini-Mental State Examination (MMSE), an assessment of serum 25(OH)D level (chemiluminescent immunoassay; Access 2, Beckman Coulter, USA) were studied. Clinical efficacy of cholecalciferol was evaluated in 68 patients in the prospective cohort study design. Micellated water-soluble form of cholecalciferol in standard doses recommended by the Russian Association of Endocrinologists (RAE) was used.

Results. Vitamin D deficiency and insufficiency are associated with increased parameters of body weight (p = 0.048), waist circumference (p = 0.018) and hips (p = 0.016), increased cases of decreased performance (p = 0.046) and subclinical symptoms anxiety (p = 0.033). Supplementation of standard therapeutic and maintenance doses of cholecalciferol for 6 months contributed to a significant reduction in neurovegetative component of modified menopausal index in 54.4% of cases (p = 0.035) and improvement in cognitive function parameters in 50.0% of cases (p = 0.023) in late postmenopausal patients.

Conclusions. The use of cholecalciferol in adequate doses can be considered as an important component of complex therapy for women in late postmenopausal period.
Support of the luteal phase in programs for transferring thawed embryos into the uterine cavity in patients with overweight and obesity
Authors: Makarova N. P. , Kraevaya E. E. , Kalinin A. P.
Published: November 2024

Introduction. Progesterone levels are a critical factor for embryo implantation in in vitro fertilization (IVF) programs, including thawed embryo transfer programs. Overweight/obese patients often have lower blood progesterone concentrations in the luteal phase during IVF cycles, which requires an individual approach to planning luteal support in this category of patients.

Aim. To compare the pregnancy ratе and miscarriage rates up to 12 weeks of pregnancy in overweight/obese patients who underwent a program of transfer of thawed embryos into the uterine cavity, depending on the type and route of administration of gestagens.

Materials and methods. The study included 76 overweight or obese patients. All patients were treated for infertility using a program for transferring a thawed embryo into the uterine cavity; luteal phase support was carried out either using micronized progesterone, identical to natural, – the drug Utrogestan in a daily dose of 800 mg intravaginally (40 patients), or combination therapy was prescribed – vaginal gel with progesterone 90 mg in combination with the synthetic progestin dydrogesterone in a daily dose of 30 mg, taken orally (36 patients).

Results. The rates of pregnancy and miscarriage in the first trimester were comparable in both groups and did not depend on differences in luteal support.

Conclusions. The formation of the luteal phase of the cycle in patients with overweight/obesity is equally effective using various forms of gestagens. The use of micronized progesterone may be preferable in patients with overweight/obesity in terms of the ability to monitor blood progesterone levels, a more favorable metabolic profile when used vaginally, and the possibility of switching to oral administration of the drug in the event of the development of adverse local events.
Iron deficiency anemia and anemia of chronic disease – what is known?
Authors: Solovyeva A. V. , Spitsyna M. A. , Magomedova P. I. , Aleinikova E. Yu. , Gulenkova K. A. , Chegus L. A.
Published: November 2024

Anemia is the most common disease in the world, affecting about 30–40% of people. Children, adolescents, and women are most often affected by anemia. The main causes of true iron deficiency (ID and IDA) are insufficient iron intake, increased iron loss (chronic bleeding), increased iron requirement, and impaired iron absorption (gastrointestinal diseases). Chronic diseases, inflammatory conditions, autoimmune diseases, obesity cause an increase in the synthesis of hepcidin in the liver and block the entry of iron into the bloodstream, leading to functional iron deficiency. Anemia of chronic diseases (ACD) or anemia of chronic inflammation (the second most common anemia) is associated with the fact that iron is present in the body, but the absorption of iron in various areas is limited. Until recently, it was believed that treatment with iron supplements in the absence of iron deficiency does not bring benefit to patients with ACD. The opinion has been repeatedly expressed about the harm of iron therapy, since iron is necessary for the growth of some pathogenic microorganisms and tumor cells. However, the real clinical significance of these mainly theoretical provisions is unknown. Therefore, the prescription of iron preparations for anemia is justified and logical. Ferrous sulfate (ferrous iron) is most often prescribed orally due to its low cost, high bioavailability and effectiveness. The drug Tardiferon, containing iron sulphate 247.25 mg (in terms of iron (II) 80.00 mg), is widely used in patients with IDA and ID, since divalent iron has a high ability to overcome the intestinal barrier by “passive” transport and quickly create high concentrations in the blood, restoring the level of hemoglobin and iron stores in the body. The drug Tardiferon has a relatively low dose of iron – 80 mg with slow-release technology to avoid irritating effects on the intestine, contributing to good tolerability. A number of studies confirmed a high safety profile – patients did not refuse to take the drug due to side effects. Timely examination and identification of patients with anemia allows you to prescribe an effective correction. The drug Tardiferon promotes rapid restoration of hemoglobin and iron stores in the body and has good tolerability.