bluuebunny/crossref_metadata_2025 huggingface dataset:
Portrayal of Female Violence in the Bible: the Stories of Jael and Judith
Authors: Teslyuk Halyna
Published: November 2021

This article offers an analysis of the biblical stories about two heroines: Jael and Judith who save their people by killing the foreign generals. Both stories narrate critical historical situations, namely Jael’s story in Judges 4–5 dates to the XII–X cc. B.C.E. and reflects the ongoing conflict between the twelve tribes of Israel with their neighbors in the land of Canaan, Judith’s story dates to the II c. B.C.E. and reflects the conflict between the Jews and the Seleucid rulers who oppressed the Jewish populace, forced them to practice Hellenistic rituals and abandon the Jewish law and religious practices. Jael invites Sisera, a commander of the Canaanite army of king Jabin, to her tent, gives him milk to drink, and when the man falls asleep, she kills him with a hammer and а tent peg. Judith, a widow from the town of Bethulia, uses her beauty and charm to kill Holofernes, an Assyrian general. First, she gains his trust. Then, when Holofernes drunken falls asleep, she decapitates him in his tent. These texts explicitly show the collapse of the male power and demonstrate the ability of women to step in to save the people. Both heroines are praised by the narrators for their heroism. It is also demonstrated that Jael’s and Judith’s stories have an aim to teach how one may think out of the box. Due to the lack of male capability to solve the problem or, in other words, to protect the people as it is expected according to the patriarchal norms, social roles are shifted, and perception of masculinity and femininity is reеvaluated. The heroic stories of Jael and Judith represent the idea that women can be subjects of history, violence as а means to protect people is not limited to the male domain, and women can save people in critical situations. The violence performed by the women is perceived as an extraordinary act yet necessary and not deviant in the situation.
Translation Program and “Philosophy” Series
Authors: Lyuty Taras
Published: November 2021

The review presents the main translations of the classics of philosophical literature in previous years. The publication was made in cooperation with the Mizhvukhamy Foundation and the Tempora Publishing House. The main stress of the review is made on the works of Emanuele Severino, Ibn Sina, Henry David Thoreau and Edmund Husserl.
SYNTHESIS AND CHARACTERIZATION OF COORDINATION COMPOUNDS OF 3d-METAL MALEATES WITH THIOSEMICARBAZIDE
Authors: Koksharova T. V. , Mandzii T. V. , Kovalyov A. Yu. , Kramarenko D. V. , Brazhnik T. Yu. , Ivanenko O. K.
Published: November 2021

Complexes of copper(II), nickel(II), cobalt(III), and zinc(II) maleates with thiosemicarbazide were synthesized. The resulting compounds were characterized by the elemental analysis data, infrared spectroscopy, diffuse reflectance spectroscopy, and thermogravimetry.
REDOX PROCESSES IN THE REACTIONS OF N-ARYLSULFONYL-1,4-NAPHTНOQUINONЕIMINES WITH CERTAIN NUCLEOPHILES
Authors: Avdeenko A. P. , Kholmovoi Yu. P. , Yusina A. L.
Published: November 2021

Quinone-hydroquinone pairs are prototypes of organic redox systems, and studies of the electrochemical behavior of these compounds are of great interest for research. Electrochemical behavior associated with the equilibrium of electron-proton transfer provides information about the molecular structure and environment of the process. Apart from chemical aspects, quinones play an important role in the biochemistry of living cells. Quinone derivatives, used as drugs for several types of human cancers, have been found to have their biological activity related to their redox behavior. Quinoneimines-aminophenols form similar pairs. In nucleophilic addition reactions of N‑substituted p-quinoneimines, parallel redox processes are often observed, and the higher the redox potential of quinoneimine, the greater the likelihood of such processes. Naphthoquinoneimines with aromatic amines and acylhydrazines follow the scheme of 1,4-addition, but as reaction products are oxidized products -4-arylsulfonylamido‑2-arylamino(2-aroylamino)-1,4-naphthoquinoneimines. The oxidant may be the original naphthoquinoneimine and oxygen. Studies have shown that oxygen in the reaction of 1,4-naphthoquinoneimines with acylhydrazines is the only oxidant that oxidizes the product of 1,4-addition, as evidenced by the study of redox potentials. Both oxidized and reduced form of the compounds, as naphthoquinoneimine and the corresponding aminonaphthol, are used to determine the redox potential by direct potentiometry. Due to the instability of the reduced form in the case of the pair naphthoquinoneimine-aminonaphthol, we used only the reduced form, which is oxidized in the cell by oxygen. The redox potential of the naphthoquinoneimine-aminonaphthol galvanic pair was determined as the average value between the potential Emax, which was established in the system upon complete oxidation of the starting substance, that is, when only naphthoquinone imine remains in the system, and the potential Emin, which was registered at the beginning of the process in the system with the reduced form – the corresponding aminonaphthol. This is the method of direct potentiometry in the variant of the middle potential.
A Hospital-Based Study of EGFR and ALK Mutations in Patients with Lung Adenocarcinoma in Odisha
Authors: Parida Prasant Kumar , Dash Sashibhusan
Published: November 2021

Background: Patients with advanced non-small cell lung cancer (NSCLC) have considerably benefited from the molecular identification of epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) mutations and subsequent targeted therapy against these biomarkers. Few studies have been undertaken in the Indian population on the analysis of both EGFR and ALK mutations in lung adenocarcinoma cases.
Aim and Objectives: The aim of this study was to determine the prevalence of EGFR and ALK mutations in lung adenocarcinoma patients, as well as to link mutational status with age, sex, and smoking history.
Materials and Methods: This single hospital-based retrospective study was conducted at the Department of Medical Oncology, Acharya Harihar Post Graduate Institute of Cancer, Cuttack, on histologically proven lung adenocarcinoma cases over a duration of two years from 01.08.2019 to 31.07.2021.
Results: Out of a total of 164 cases, males comprised 89 (54.26%) of the 164 lung adenocarcinoma cases, while females comprised 75 (45.73%). EGFR mutations were found in 42 (26.75%) of the patients. In 9 cases, the ALK gene rearrangement was also determined to be positive (5.66%). In terms of EGFR and ALK mutations, there was no statistically significant relationship between patient age and gender. (P-value < 0.05). In our research, we found a link between nonsmokers and EGFR and ALK mutations. (P-value <0.05). The deletion of exon 19 (76.19%) was the most prevalent mutation, followed by the exon 21 L858R mutation (14.28%).
Conclusion: This study was found to have a significantly higher rate of EGFR and ALK mutation in the Indian population with adenocarcinoma of lung compared to Western populations. To get the maximum benefit from targeted therapies, all patients of adenocarcinoma of the lung should have mutational testing for EGFR and ALK as part of a broad molecular pannel.
Epidemiology and structure of traumatic injuries of ear in the Karachay-Cherkessk Republic
Authors:   Medical Institute of the North Caucasus State Academy, Cherkessk, 369015, Russia, Gyusan A. O. ,   Karachay-Cherkess Republican Clinical Hospital, Cherkessk, 369000, Russia, Uraskulova B. B. ,   Medical Institute of the North Caucasus State Academy, Cherkessk, 369015, Russia,   Karachay-Cherkess Republican Clinical Hospital, Cherkessk, 369000, Russia, Uzdenova Kh. A. ,   Karachay-Cherkess Republican Clinical Hospital, Cherkessk, 369000, Russia
Published: November 2021

The growth of emergencies, increased traffic and overall technological progress led to an increase in the number of traumatic injuries, including the organ of hearing. The lack of information on the structure and prevalence of traumatic injuries of the organ of hearing makes it difficult to plan and increase the effectiveness of the organization of specialized care for such victims. To study the prevalence and structure of traumatic injuries of the hearing organ in the Karachay-Cherkess Republic, the medical records of patients with various ear injuries who were treated in the departments of the Karachay-Cherkess Republican Clinical Hospital over the past three years were analyzed. The prevalence of traumatic injuries of the organ of hearing and its structure was determined according to the data of hospitals of the republican hospital. There was a tendency toward an increase in patients with ear injuries in all age groups. Maintaining the predominance of mechanical trauma, with an increase in the number of victims with baro- and acoustic trauma. The features of damage to the structures of the organ of hearing are examined and it is emphasized that the mechanism of trauma determines the tactics of the victim. The scale of hearing injuries and their consequences require a more in-depth study of their regional characteristics, risk factors to develop all possible preventive measures.
Development of frozen-fried yam slices: optimization of the processing conditions
Authors:   University of Abobo-Adjamé, Côte d’Ivoire, Touré Y ,   Swiss centre of Scientific Research, Côte d’Ivoire,   University of Liege–Gembloux Agro-Bio Tech, Belgium, Nindjin C ,   University of Abobo-Adjamé, Côte d’Ivoire, Brostaux Y ,   University of Liège–Gembloux Agro-Bio Tech, Belgium, Amani GN ,   University of Abobo-Adjamé, Côte d’Ivoire, Sindic M ,   University of Liège–Gembloux Agro-Bio Tech, Belgium
Published: November 2021

The research performed on yam processing mainly concerns the production of crisps and flour. However, its transformation into deep-frozen French fries does not necessitate any other equipment than those used for potatoes. The industrial process of production of frozen French fries traditionally includes a pre-frying step. These steps contribute to the development of color and crispness, and the oil partially absorbed inhibits dehydration during the freezing step. The aim of this study was to optimize frying conditions of deep-frozen fried yam (Dioscorea cayenensis var Kponan) slices. The effect of pre-frying time and temperature, final frying time and temperature on the oil uptake, texture, dry matter and colour of the fried yam slices has been studied. Frying conditions optimized with Box-Behnken experimental design were short pre-frying and frying conditions at high temperature characterized by prefrying temperature at 157-170°C during 5-9s and frying temperature at 181-188°C for 2min 15s-2min 30s; or long pre-frying and frying conditions at low temperature characterized by pre-frying temperature at 150-158°C during 10-15s and frying temperature 170-177°C for 3-3min 15s. An adiabatic system was also developed by means of an insulator in which the core temperature of fried yam slices can be maintained constant at about 55°C after 15min of cooling, facilitating texture measurements at constant temperature. The present results may help in choosing the yam slices frying condition to be applied in order to achieve the desirable fried yam slices quality, required for protection against certain diseases like obesity. These models may also provide guidance as to how to control these quality parameters by altering four key environmental factors, pre-frying temperature and time and, final frying temperature and time. This process can also be commercialized and does not necessitate any other cost for equipment than those used for potatoes French fries and might be an interesting way of added value processing for this highly perishable yam tuber.
The Blizzard of the World: COVID-19 and the Last Say of the State of Exception
Authors: Tacik Przemysław
Published: November 2021

The paper aims to grasp the COVID-19 pandemic as a socio-political catastrophe in the Benjaminian sense. As argued in the article, the scope and nature of the COVID-19 crisis eludes us due to our closeness to its inner core. What is obfuscated in this moment is the politico-legal framework on which the international community is based, where sovereignty and turbocapitalism join their forces to produce biopolitical devices. The paper looks into uses of the state of exception in particular countries, concluding that the rule of law in the pandemic was generally put on the back burner even by the countries that officially praise it. Sovereignty clearly returned to the stage, undermining parliamentarism and civil liberties in the sake of necessity. International law remained incapable of addressing this return, let alone of enforcing responsibility of China for infringing WHO rules. As a conclusion the paper argues that COVID-19 opened new-old paths of governing the living that will play a planetary role in the future fights for dominance and imposing a new face of capitalism.
Prevention of Septal Perforation Using a Combination of Crushed Cartilage and Thin Silastic Sheet During Septoplasty
Authors: Kim Young Gun , Kim Sang Jun , Bae Woo Yong
Published: November 2021

Background and Objectives: The aim of the present study was to investigate the effects of a combination of crushed cartilage and thin silastic sheet for patients with a risk of septal perforation during septoplasty.Materials and Methods: A total of 195 people who underwent septoplasty surgery at Dong-A University Hospital from January 2019 to December 2020 were enrolled retrospectively. Among 195 people, our surgical method was provided for those with damage to both septal mucosa. The cartilage was collected, crushed with the cartilage crusher, and inserted between perforated mucosa. After the cartilage insertion, a 0.254-mm-thin silastic sheet was designed to cover both sides of the perforated septal mucosa. Next, a penetrating suture was placed. After thin silastic was applied on both mucosa, a 1-mm-thick silastic sheet was inserted on both sides of the nasal cavity and penetrating sutures were placed on the anterior and inferior septum. The operation concluded after packing both sides of the nasal cavity using non-absorbable packing material. The packing was removed on the second day after the operation, and the nasal cavity condition was checked every week. Thick silastic sheets were removed 5 days after surgery, and thin silastic sheets were maintained until both septal mucosa healed.Results: Of nine total cases, only one 78-year-old male experienced septal perforation at the cartilage portion two months after surgery. In this case, no other action was taken to cover the perforation site because he reported no symptoms or discomfort during the 9 months after surgery. In the other eight cases, both septal mucosa healed completely, and there were no complications.Conclusion: This method with crushed cartilage and silastic sheets to fill the defect after septal surgery is thought to help prevent postoperative perforation at no additional cost, and further research is needed.
Practical Review of Biologics in Chronic Rhinosinusitis With Nasal Polyps
Authors: Lee Ki-Il , Ryu Gwanghui , Yoo Shin Hyuk , Kim Yong Min , Mo Ji-Hun , Shin Seung-Heon
Published: November 2021

Well-characterized in chronic rhinosinusitis, type 2 inflammation is frequently associated with nasal polyps, comorbid asthma, and nonsteroidal anti-inflammatory drug hypersensitivity. Despite medical and surgical treatment, it recurs in a significant proportion of patients. Thus, severe uncontrolled type 2 chronic rhinosinusitis with nasal polyps is the most difficult-to-treat phenotype of chronic rhinosinusitis. Recently, dupilumab, a monoclonal antibody against IL-4 receptor α, and omalizumab, a monoclonal antibody against immunoglobulin E, were approved for patients with chronic rhinosinusitis with nasal polyps in the United States, Europe, and Korea. Therefore, rhinologists should understand novel biologics and their use. Here, we provide a literature review of several biologics with their indications, effectiveness, and safety.
Study on the In vitro and In vivo Antifungal Activities of Nano-silver against Mycoleptodiscus indicus causing Leaf Blight on Lotus in Vietnam
Authors: Hong Hoang Thi Kim , Vu Nguyen Quang Hoang , Hanh Nguyen Thi Ngoc , Ha Tran Thi , Dung Le Quang Tien
Published: November 2021

Background: Lotus, Nelumbo nucifera Gaertn is Vietnam’s symbol and Buddhism’s flower and plays an essential part in rural Vietnam’s economy as all aspects of lotus could bring benefits to farmers. But, unfortunately, lotus yield in Vietnam is seriously affected by various plant diseases. Among them, leaf blight is currently emerging as one of the primary diseases devastating lotus crops in Vietnam, in which there are large necrotic parts on lotus leaves, flowers and seeds. Methods: Aloe barbadensis extract was used for synthesizing silver nanoparticles. Leaf blight lotus leaves were collected to isolate pathogenic fungi-infection of isolated pathogenic fungi on the healthy lotus and then identify hidden mold by 28S rRNA sequencing. Determination of in vitro minimal inhibition concentration of nano-silver was conducted according to Azizi. The reduction of disease symptoms and biological characteristics of the treated lotus was observed. Result: Morphological analysis and molecular identification of 28S rRNA sequencing showed that the pathogenic microorganism was Mycoleptodiscus indicus (M. indicus). Both in vitro antifungal activity and in vivo treatment of leaf blight lotus using a nano-silver solution showed that 30 ppm of nano-silver was the minimal inhibition concentration (MIC) for totally eradicating M. indicus growth. This was the first time M. indicus was reported to infect and cause leaf blight on a lotus. Previously, M. indicus was a well-known plant pathogen that could cross-kingdom infect humans and animals. Thus, the fact that lotus is widely cultured in Vietnamese rural could increase the chance for M. indicus to spread; hence, this raised the alarm about its potential harm to plants, humans and animals. And, significantly, it revealed nano-silver as a possible approach to prevent M. indicus.
A Multi-Phase Assessment of the Effects of COVID-19 on Food Systems and Rural Livelihoods in Malawi
Authors: Matita Mirriam , Chimombo Masautso
Published: November 2021

The COVID-19 pandemic has caused disruptions to national and global economies with devastating effects on food systems and livelihoods across the globe. These effects of the pandemic on poverty, hunger, and malnutrition, among others, are likely to be greater among low and middle-income countries like those in sub- Saharan Africa, including Malawi. This is because even before the COVID-19 pandemic began the proportion of people facing poverty, and food and nutrition insecurity were already high. It is, therefore, imperative to understand the effects of COVID-19 on food systems and rural livelihoods. Using a multi-stage ‘rapid assessment’, this study provides real-time insights into how the COVID-19 crisis unfolded in Malawi and how rural people and food and livelihood systems respond.
Vulnerability and Poverty During Covid-19: Religious Minorities in Nigeria
Authors: Howard Joanna , Para-Mallam Oluwafunmilayo , Dayil Plangsat Bitrus , Hayab Philip
Published: November 2021

The Covid-19 pandemic has had direct and indirect effects on religiously marginalised groups, exacerbating existing inequities and undermining ambitions for those ‘furthest behind’ to be reached and supported through the Sustainable Development Goals (SDGs). The intersection of religious identity, socioeconomic status, geographic location, gender, and age compound vulnerability to violence and its impacts. This policy briefing, written by Dr Joanna Howard, Professor Oluwafunmilayo Para-Mallam, Dr Plangsat Bitrus Dayil, and Dr Philip Hayab, draws on research into the experiences of the pandemic by religious minorities living in Kaduna and Plateau states in Nigeria and finds that the pandemic deepened pre-existing ethno-religious fault lines. Exacerbated by ongoing insecurity, it contributed to increased poverty, with women particularly affected, and worsening mental health, with people experiencing fear, frustration, and depression. There are also long-term consequences for development; for example, on children’s education.
The Tensions Between Student Dropout and Flexibility in Learning Design: The Voices of Professors in Open Online Higher Education
Authors: Xavier Marlon , Meneses Julio
Published: November 2021

Flexibility is typical of open universities and their e-learning designs. While this constitutes their main attraction, promising learners will be able to study “anytime, anyplace,” this also demands more self-regulation and engagement, a cause for student dropout. This case study explores professors’ experiences of flexibility in e-learning design and continuous assessment and their perception of the risks and opportunities that more flexibility implies for student persistence and dropout. In-depth interviews with 18 full professors, who are the e-learning designers of undergraduate courses at the Open University of Catalonia (UOC), were analyzed, employing qualitative content analysis. According to the professors, the main causes for dropout are student-centered, yet they are connected to learning design: workload and time availability, as well as students’ expectations, profiles, and time management skills. In the professors’ view, flexibility has both positive and negative effects. Some are conducive to engagement and persistence: improvement of personalized feedback, formative assessment, and module workload. Others generate resistance: more flexibility may increase workload, procrastination, dropout, and risk of losing professorial control, and may threaten educational standards and quality. Untangling the tensions between dropout and flexibility may enhance learning design and educational practices that help prevent student dropout. Stakeholders should focus on measures perceived as positive, such as assessment extension, personalized feedback and monitoring, and course workload calibration. As higher education is globally turning to online delivery due to the COVID-19 viral pandemic, such findings may be useful in both hybrid and fully online educational contexts.
Kajian Pustaka: Sumber Reactive Oxygen Species (ROS) Vaskular
Authors: Susilawati I Dewa Ayu
Published: November 2021

Increasing amount of vascular reactive oxygen species (ROS) play a key role in the pathogenesis of almost all stages of cardiovascular diseases (CVD), such as atherosclerosis, hypertension, myocardial infartion, etc. This paper aimed to present a brief review of the important vascular sources of ROS. Vascular ROS is mainly produced by enzymatic sources in the vascular cells, i.e. phagocytic inflammatory cells (neutrophils, monocytes/macrophages), and nonphagocytic cells (endothelium, smooth muscle cell and fibroblast). Enzymatic sources of vascular ROS are NADPH oxidase, xanthine oxidase, eNOS, lipoxygenase, cyclooxygenase, and mitochondrial electron transport. In conclusion, over production of ROS induce oxidative burst and will be detrimental for cardiovascular health. A better understanding of ROS would be worwhile for developing method for preventing CVD based on ROS inhibition.
Enhancing Auditor Independence in Developing Countries in Context of Globalization – Evidence in Vietnam
Authors: Duc Le Doan Minh
Published: November 2021

Purpose: Globalization brings many opportunities and challenges for developing countries. So, does globalization create a motivation to improve the auditing profession's ethics? Independence is one of the most important components of auditing professional ethics, which must be maintained throughout the audit process. This article delivers a full insight into identifying factors that enhance the auditor independence promoted in the international integration process. Design/methodology/approach: This article approached from international integration process that affect auditor independence from auditors’ awareness, working environment and professional association. This article used a mixed approach based on the experimental methodology. This article used the archival research method and group discussions method to analyze and assess the research problems and verified by experimental data. The article took the group discussions with experts and survey 280 directors, auditors, auditor assistants who are working in 70 auditing firms. Findings: The results showed that globalization support auditors, audit firms, and professional Association to improve auditor independence. Especially, the factors that enhance the auditor independence driven by international integration: Knowledge, Technology, Competition, Management, Monitoring. Practical implications: The article implied to improve auditor independence in the context that Vietnam is strongly integrating internationally. Originality/value: The article has taken a new approach on auditor independence from globalization in Vietnam.
Revisiting the Relationship between Poverty and Environmental Sustainability in Sub-Saharan African Countries using Dynamic Econometric Models
Authors: Mensah Owusu Samuel , Jianlin Chen , Chuambo Fu , Qio Hu
Published: November 2021

Sustainable development remains an important issue in the quest to achieve a safe and a better world. The expansion of the 8 millennium development goals into the 17 sustainable development goals is a testament of the conscious desire to improve the human environment to ensure better quality of life for its citizens. This study assembles a collection of four sophisticated econometric models to determine the impact of poverty and other variables on two indicators of environmental sustainability. Beside, economic development, the study confirmed the negative impact of poverty on both indicators of sustainable development. The results prove that poverty in sub-Saharan Africa is a threat to environmental quality and its consequential challenges. The call to promote environmentally responsible behaviours should not be focused on developed countries alone. Poverty is also associated with high levels of pollution and poor countries including countries in sub-Saharan Africa contributes must equally restrategise for effective environmental goals. The study further discloses that poverty is one of the strongest factors that affect environmental sustainability. This observation is not a contradiction to the well-established fact that prosperity or economic growth is a major precursor of unsustainable environment. On the contrary the evidence in this paper amplifies a consequence of a social crisis if they fester at both ends. In one breath, whereas economic growth or economic prosperity can compromise the quality of the environment. In conclusion, this result implies that African countries in their pursuit of economic growth, education and effective healthcare to ameliorate poverty must incorporate other aggressive strategies to hasten poverty reduction.
POLA ASUH ORANG TUA DALAM MEMBENTUK KARAKTER MANDIRI ANAK DIMASA BELAJAR DARI RUMAH (BDR)
Authors: Yanti Noor Halida
Published: November 2021

AbstrakPenelitian ini bertujuan untuk mengetahui pola asuh orang tua dalam membentuk karakter mandiri anak dimasa belajar dari rumah (BDR) pada Anak Usia Dini, adapun yang menjadi subjek penelitian adalah orang tua yang anaknya bersekolah di PAUD Terpadu At-Tibyan Banjarmasin. Menggunakan metode penelitian kualitatif dengan jenis naturalistic inquiry (ingkuri alamiah). Teknik pengumpulan data penelitian adalah observasi, wawancara, dan dokumentasi. Hasil penelitian menunjukkan bahwa pola asuh Authoritarian atau demokratis yang paling baik digunakan dalam membentuk karakter mandiri anak dimasa BDR walaupun pada aplikasinya dilapangan orang tua masih ada yang menggunakan pola asuh Authoritative dan permisif sehingga dapat menghambat pembentukan karakter anak usia dini dimasa BDR.Kata Kunci: Pola Asuh, karakter mandiri, BDR AbstractThis study aims to determine parenting styles in forming the independent character of children in the learning period from home (BDR) in early childhood, while the research subjects are parents whose children attend PAUD Terpadu At-Tibyan Banjarmasin. Using qualitative research methods with the type of naturalistic inquiry (natural ingkuri). Research data collection techniques are observation, interviews, and documentation. The results showed that authoritarian or democratic parenting is best used in shaping children's independent character during BDR, although in its application in the field of parents, there are still those who use authoritative and permissive parenting styles so that it can inhibit the formation of early childhood character during BDR.Keywords: Parenting, independent character, BDR
MENGEMBANGKAN MOTORIK HALUS MENGGUNAKAN METODE DEMONSTRASI, PEMBERIAN TUGAS, DAN TEKNIK MOZAIK TK AL-AMIN MARTAPURA
Authors: Nurul Hikmah , Sulistiyana Sulistiyana
Published: November 2021

Permasalahan penelitian ini adalah belum berkembangnya motorik halus dalam menempel pada tahun 2020/2021 sebanyak 8 orang dari 10 anak dengan persentase 80% kelompok B3 di TK Al-Amin Martapura Kabupaten Banjar. Penyebabnya pembelajaran online kurang jelas, proses kegiatan pembelajaran tidak terlibat langsung, dan tidak ada media lain yang lebih variatif hanya menggunakan buku Lembar Kerja Anak. Solusi yang digunakan adalah metode demonstrasi, pemberian tugas, dan teknik mozaik. Tujuan penelitian ini untuk mendeskripsikan pelaksanaan dan menganalisis perkembangan motorik halus anak menempel melalui penggabungan metode demonstrasi, pemberian tugas, dan menggunakan teknik mozaik. Penelitian ini sebanyak 3 siklus menggunakan pendekatan kualitatif  jenis Penelitian Tindakan Kelas (PTK). Subjek penelitian ini anak kelompok B3 TK Al-Amin Martapura Kabupaten Banjar. Hasil dari penelitian menunjukkan bahwa aktivitas guru peroleh skor 23 kriteria sangat baik, aktivitas anak peroleh 90% kriteria sangat aktif, dan hasil capaian pengembangan motorik halus mencapai 90% kategori Berkembang Sangat Baik. Disimpulkan melalui kombinasi dari metode demonstrasi dan pemberian tugas dapat mengembangkan motorik halus menempel dengan teknik mosaik.
MENGEMBANGKAN KEMAMPUAN BAHASA MENGGUNAKAN KARTU CERMAT (BERCAKAP-CAKAP, ARTIKULASI, MAKE A MATCH) PADA ANAK KELOMPOK A
Authors: Annisa Risma Nor , Asniwati Asniwati
Published: November 2021

Ketertarikan penelitian anak RA dapat memunculkan ide-ide baru yang dapat meningkatkan kemampuan anak dalam mengungkapkan kalimat dan memperkaya perbendaharaan kata yang menjadi acuan dalam berbicara pada kemampuan bahasa. Tujuan penelitian ini untuk mendeskripsikan aktivitas guru, aktivitas anak serta hasil pengembangan kemampuan bahasa dalam mengulang kalimat sederhana dan memperkaya perbendaharaan kata. Penelitian ini menggunakan pendekatan kualitatif dengan jenis Penelitian tindakan kelas dilaksanakan dalam 3 kali pertemuan. Subjek penelitian berjumlah 10 orang anak, yaitu 5 anak laki-laki 5 anak perempuan. Hasil penelitian menunjukkan bahwa aktivitas guru terlaksana dengan sangat baik. Aktivitas anak meningkat dengan kategori sangat aktif dan hasil perkembangan kemampuan bahasa anak memperoleh kategori Berkembang Sangat Baik (BSB). Diharapkan hasil penelitian tersebut dijadikan sebagai referensi agar dapat mengembangkan kemampuan anak pada aspek perkembangan bahasa.
PENGGUNAAN BIOFILTER ANAEROB UNTUK MENURUNKAN KADAR PENCEMAR ORGANIK PADA LIMBAH CAIR INDUSTRI TAHU
Authors: Kholif Muhammad Al , Alfiah Frisyi , Sugito Sugito , Pungut Pungut , Sutrisno Joko
Published: November 2021

Limbah cair industri tahu mengandung zat organik yang tinggi seperti BOD5 dan COD sehingga perlu adanya pengolahan sebelum dibuang ke lingkungan. Salah satu alternatif pengolahan yaitu menggunakan sistem biofilter anaerob. Penelitian ini bersifat eksperimental yang bertujuan untuk mengetahui penurunan kadar BOD5 dan COD pada limbah cair industri tahu menggunakan sistem biofilter anaerob. Reaktor yang digunakan terdiri dari 2 buah reaktor dan terbuat dari kaca dengan ketebalan 10 mm. Reaktor pertama bervolume 0,081 m3 yang diisi dengan media batu kerikil setinggi 70 cm dan reaktor kedua bervolume 0,059 m3 diisi dengan media bioball rambutan setinggi 45 cm. Limbah cair industri tahu dialirkan ke dalam reaktor biofilter anaerob secara kontinyu dengan arah aliran down flow. Parameter yang diukur yaitu kadar BOD5 dan COD pada inlet maupun outlet reaktor biofilter anaerob. Reaktor 1 bermedia batu kerikil mampu menyisihkan kadar BOD5 dengan penyisihan tertinggi terjadi pada waktu operasi hari ke-4 yaitu sebesar 943,8 mg/L dan penyisihan kadar COD tertinggi pada waktu operasi hari ke-4 yaitu sebesar 1931,2 mg/L. Sedangkan pada reaktor 2 bermedia bioball rambutan mampu menyisihkan kadar BOD5 dengan penyisihan tertinggi terjadi pada waktu operasi hari ke-4 yaitu sebesar 936,7 mg/L dan penyisihan kadar COD tertinggi pada waktu operasi hari ke-4 yaitu sebesar 1856,6 mg/L.  Kata Kunci : batu kerikil, bioball rambutan, biofilter anaerob, limbah tahu.  Tofu industrial liquid waste contains high organic matter such as BOD5 and COD so it needs processing before being discharged into the environment. One of alternative processing is using an anaerobic biofilter system. This study is experimental which aims to determine the decrease of BOD5 and COD levels in tofu wastewater using anaerobic biofilter system. The reactor consist is 2 reactors and is made of glass with a thickness of 10 mm. The first reactor with a volume of 0.081 m3 was filled with 70 cm of gravel media and a second reactor with a volume of 0.059 m3 filled with 45 cm of rambutan bioball media. Tofu industrial liquid waste is flowed into the anaerobic biofilter reactor continuously with down flow direction. Parameters measured were BOD5 and COD levels at the anaerobic biofilter reactor inlet and outlet. The highest removal of BOD5 levels in reactor 1 with gravel media occurred on the 4th day of operation with a allowance of 943.8 mg/L and the highest removal of COD levels at the 4th day of operation was 1931.2 mg/L. Whereas the highest removal of BOD5 levels in reactor 2 with rambutan bioball media occurred on the 4th day of operation with a allowance of 936.7 mg/L and the highest removal of COD levels at the 4th day of operation with a allowance of 1856.6 mg/L. Keywords: anaerobic biofilter, gravel stone, rambutan bioball, tofu waste.
Rasgos de personalidad y psicopatología en adolescentes con adicción a videojuegos
Authors: Sánchez-Llorens Marta , Marí-Sanmillán María Isabel , Benito Ana , Rodríguez-Ruiz Francesc , Castellano-García Francisca , Almodóvar Isabel , Haro Gonzalo
Published: November 2021

El trastorno por uso de videojuegos se incluyó recientemente en la 11ª edición de la Clasificación Internacional de Enfermedades. Se realizó un estudio transversal en cinco institutos, con una muestra final de 119 alumnos. El 6,4% (n = 23) de los sujetos tenía trastorno por uso de videojuegos. Los adolescentes con trastorno por uso de videojuegos mostraron bajos niveles de consciencia (F = 7,82; p = ,001) y amabilidad (F = 3,31; p = ,041); y puntuaron más alto en inadaptación escolar (SMC; F = 9,230; p < ,001) que los sanos. Obtuvimos dos funciones discriminantes que clasificaban correctamente al 60,5% (Z1 = 0,406 × Sexo + 0,560 × Conciencia - 0,677 × SMC; Z2 = 0,915 × Sexo + 0,191 × Conciencia + 0,326 × SMC). Los sujetos con adicción se diferenciaban de los sanos en presentar inadaptación escolar y baja conciencia, mientras que ambos grupos con adicción se diferenciaban en que los alumnos con adicción a videojuegos eran en mayor proporción varones. La probabilidad de trastorno por uso de videojuegos aumentaba si el sujeto era varón (OR [CI 95%] = 4,82 (1,17-19,81); p = ,029) con inadaptación escolar (OR [IC 95%] = 1,08 (1-1,17); p = ,047); mientras que el trastorno por uso de sustancias aumentaba si el sujeto presentaba neuroticismo (OR [IC 95%] =1,07 [1-1,14]; p < ,040), desajuste clínico (OR [IC 95%] = 1,10 [1,01-1,20]; p = ,020), inadaptación escolar (OR [IC 95%] = 1,06 [1-1,13]; p = ,048), bajo ajuste personal (OR [IC 95%] = 0,94 [0,88-0,99]; p = ,047) y síntomas emocionales (OR [IC 95%] = 0,86 [0,78-0,96]; p = ,006).
Hypothalamic-pituitary-adrenal axis dysregulation initiated by a binge drinking pattern, but not by acute alcohol intake, in female and male adolescents
Authors: Ramírez-Piña Milton , Monleón Santiago , Vinader-Caerols Concepción
Published: November 2021

Excessive alcohol consumption is a worldwide public health problem, being adolescents and young adults the population most affected by this problem. The aim of this study was to clarify the effects of having a history of binge drinking (BD) and/or acute alcohol consumption on the stress response in female and male adolescents. Participants were 235 adolescents (143 females and 92 males). Cortisol, systolic and diastolic blood pressure (SBP and DBP), heart rate (HR) and perceived stress (PS) were evaluated in adolescents with different and similar blood alcohol concentrations (BAC). In Experiment 1, the effects of alcohol were studied separately in females and males because of differences in BAC. In Experiment 2, a direct comparison between sexes was carried out in a counterbalanced selection of participants with similar BAC. In Experiment 1, females receiving alcohol showed an increase in cortisol and HR, and binge drinkers displayed higher HR than refrainers. Male refrainers receiving alcohol showed higher HR, and binge drinkers showed higher cortisol and SBP than refrainers. In Experiment 2, similar results were observed and sex differences were evident, with males showing higher cortisol and SBP, and lower PS than females. In conclusion, the normal response of the adolescent HPA axis to alcohol consumption is an increase in cortisol levels in females, as well as HR in both sexes. In addition, a history of BD is associated with HPA axis dysregulation, which is manifested by higher values of cortisol (independently of sex), SBP in male and HR in female healthy adolescents.
Effect of problem-based learning model on biodiversity problem-solving skills
Authors: Komala Ratna , Heryanti Erna , Rinawati Amelia
Published: November 2021

Problem-solving skill is a way or strategy to achieve goals following good and correct procedures. One of the learning models that can be applied to improve problem-solving skills is a learning model of Problem-Based Learning. The purpose of this research was to determine the effect of the problem-based learning model on student’s problem-solving skills of biodiversity. This research was conducted at SMAN 89 Jakarta in August-September 2019. The method used was a quasi-experiment. The research sample was 66 students of class X MIA with a simple random sampling technique, the instrument used was pretest and posttest in the form of a description question. Instrument of problem-solving skills was tested for validity and reliability. The result of the validity test showed that there were 15 valid items out of 18 items. The reliability test showed that the r-value was 0,901 and included in very high criteria. The effectiveness test of the PBL model with normalized gain calculated score of 0,72 or included in the category of fairly effective. The research result showed that the problem-based learning model influenced students’ problem-solving skills of biodiversity.
Magnitude and Timing of the Tiltill Rockslide in Yosemite National Park, California
Authors: Pluhar Christopher J. , Ford Kiersti R. , Stock Greg M. , Stone John O. , Zimmerman Susan R.
Published: November 2021

Yosemite National Park, California, is one of the best-documented sites of historical rockfalls and other rock slope failures; however, past work shows that this record does not capture the infrequent largest occurrences, prehistoric events orders of magnitude larger than the largest historic ones. These large prehistoric events are evident as voluminous bouldery landslide deposits, permitting volume and age quantification to better understand local volume–frequency relationships, potential triggering mechanisms, and the hazard such events might pose. The Tiltill rockslide in northern Yosemite is one such example, consisting of 2.1 × 106 m3 ± 1.6 × 106 m3 of talus (1.5 × 106 m3 original volume of rock mass) that slid across the floor of Tiltill Valley, partially damming Tiltill Creek to create a seasonal pond that drains through and around the rockslide mass. This volume and the rockslide's effective coefficient of friction, 0.47, place it near the boundary between long-runout landslides and ordinary Coulomb failure. Although the rockslide superficially appears to consist of two separate lobes, statistically indistinguishable 10Be exposure dates from eight samples indicate a single event that occurred at 13.0 ± 0.8 ka. The age of the Tiltill rockslide and its relatively low elevation compared to equilibrium line altitudes at this place and time make glacial debutressing a highly unlikely triggering mechanism. Seismic shaking associated with fault rupture along the eastern Sierra Nevada is shown to be a plausible but unverified trigger.
Yeast-Based Directed-Evolution For High-Throughput Structural Stabilization of G Protein-Coupled Receptors (GPCRs)
Authors: Meltzer May , Tatiana Zvagelsky , Papo Niv , Engel Stanislav
Published: November 2021

The immense potential of G protein-coupled receptors (GPCRs) as targets for drug discovery is not fully realized due to the enormous difficulties associated with structure elucidation of these profoundly unstable membrane proteins. The existing methods of GPCR stability-engineering are cumbersome and low-throughput; in addition, the scope of GPCRs that could benefit from these techniques is limited. Here, we presented a yeast-based screening platform for a single-step isolation of GRCR variants stable in the presence of short-chain detergents, a feature essential for their successful crystallization using vapor diffusion method. The detergent-resistant cell wall of yeast provides a unique compartmentalization opportunity to physically link the receptor phenotype to its encoding DNA, and thus enable discovery of stable GPCR variants with unprecedent efficiency. The scope of mutations identified by the method offers important insights into the structural basis of GPCR stability, questioning the inherent instability of the GPCR scaffold, and revealing the potential role of the C-terminus in receptor stabilization.
Preliminary Study On The Data Mining of Prescriptions Containing Schisandra And The Mechanism of Diabetes
Authors: Su Yang , Li Jing , Zhang Fan , Qin Wen , Wu Lun , Gao Yue , Wang Qiuhong , Kuang Haixue , Cheng Genhong
Published: November 2021

Background: Data mining builds a bridge between ancient books of traditional Chinese medicine and modern medicine. It provides a new perspective for the precise compatibility of prescriptions and the scheme of diagnosis and treatment. Meanwhile, the mechanism of schisandrae chinensis and its compound in treating diabetes and diabetic complications is not clear. This limits the clinical application of Schisandra chinensis. Methods: Apply TCMISS to mine the core drugs with the highest frequency of combined use with Schisandra chinensis to form a new prescription. And analyze the compatibility law. Use databases such as TCMSP, TCMID, PubChem, Swiss arget prediction, disgenet and Cytoscape software. The interaction between drugs and diseases and related pathways were analyzed. In addition, autodock Vina and other software are used to calculate the molecular docking and binding energy between compounds and key targets. Finally, the therapeutic effect of the new prescription of Fructus schisandrae chinensis S·(Core) on diabetic mice was evaluated by biological experiments.Results: The study employed a data mining S·(Core) was obtained. Using network pharmacology method, mainly containing target prediction, network construction, functional enrichment analysis, and molecular docking to systematically research the mechanisms of S·(Core) in treating diabetes. The putative targets of S·(Core) that treat diabetes mainly involved AKT1, GAPDH, IL-6, MAPK3, VEGFA and other targets. The functional enrichment analysis suggested that the produced therapeutic effect of S·(Core) against diabetes is mediated by synergistical regulation of several biological pathways, AGE-RAGE signaling pathway in diabetic complications , Insulin resistance, HIF-1 and Insulin signaling pathway. The results of molecular docking showed that the core chemical components of S·core had good affinity with the key targets of diabetes. In addition,We confirmed that S·Core can improve glucose and lipid metabolism in diabetic mice. Enhanced islet β Quantity and quality of cells. Reduce the inflammatory response in the body. Liver protection.Conclusion: This study explored the mechanism of action of S·(Core) in diabetes by multi-component and multi-target multi pathways, which could provide a theoretical basis for the development and clinical application of S·(Core).
Higher Incidence of Co-Expression of BCR-ABL Fusion Transcripts in an Eastern Indian Population
Authors: Kumar Ajeet , Mishra Vatsal , Singh Chandra Bhan , Patel Rashmi , Samrat Siddharth , Rai Madhukar , Kumar Nilesh , Tilak Vijay , Gupta Vineeta , Ali Akhtar
Published: November 2021

Background

Chronic myeloid leukaemia (CML) is a hematopoietic stem cell disorder, caused by a balanced reciprocal translocation (t(9;22) (q34;q11))that lead to the formation of BCR (Break point Cluster Region)-ABL (Abelson) fusion transcripts known as Philadelphia (Ph) chromosome. Prevalence of BCR-ABL fusion transcripts in Indian CML population is poorly understood and few studies have been reported from India. The aim of present study was to determine the frequencies as well as prognostic effects of the three fusion transcripts i.e. b2a2, b3a2 and e1a2 in an Indian population.
Methods

RNA was isolated from total 123 sample 27 bone marrow (BM) sample and 96 Peripheral blood (PB) sample of CML patient followed by cDNA synthesis. Real-time quantitative reverse-transcription polymerase chain reaction (qRT-PCR) was performed using TaqMan→ assay (ABI, CA, USA) to monitor BCR-ABL transcript.
Results

Ph' chromosome was observed in 103 patients whereas it was not detected in 20 cases. qRT-PCR revealed that the b3a2 fusion transcripts was the most common transcript in CML patients (63.41%) while b2a2 fusion transcript was present in 16.26% cases. Co-expression of b3a2+b2a2 fusion transcript was observed in 0.81% cases whereas co-expression of b3a2+e1a2 fusion transcript was found in 1.63% cases. There was no co-relation observed between b3a2 fusion transcript and platelet count. The fusion transcript b2a2 was observed in relatively younger patients compared to b3a2 fusion transcript. Although this correlation was not statistically significant.
Conclusion

The co-expression of BCR-ABL fusion transcripts was higher (63.41% aggregate of b3a2) in the present population in contrast to other populations reported. This finding was consistent with the frequency data reported from Sudan.
Thermal And Kinetic Study of Electrochemical Deposition of Lead On FTO Substrate
Authors: Hamdi Ridha , Rached Amani , Ali Amor Saidi BEN
Published: November 2021

We report the electrochemical deposition of lead (Pb) onto fluorine-doped tin oxide (FTO) electrodes in a sodium nitrate bath (0.4M NaNO3) at constant potential conditions. The kinetics electrodeposition processes have been in situ monitored for advanced nucleation stages by chronoamperometry for various temperature at fixed concentration of Pb2+, that is 0.1M. The microstructure and morphological characteristics of the deposit layers were investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy dispersive X-Ray EDX techniques. The results show that the current density as well as the deposits density strongly depend on the temperature. The correlation between the experimental results and the theoretical process of the lead deposits was discussed and verified.