bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative transcriptomics reveal a novel tardigrade specific DNA binding protein induced in response to ionizing radiation
Authors: Anoud M. , Delagoutte E. , Helleu Q. , Brion A. , Duvernois-Berthet E. , As M. , Marques X. , Lamribet K. , Senamaud C. , Jourdren L. , Adrait A. , Heinrich S. , Toutirais G. , Hamlaoui S. , Gropplero G. , Giovannini I. , Ponger L. , Gèze M. , Blugeon C. , Coute Y. , Guidetti R. , Rebecchi L , Giovannangeli C. , De Cian A. , Concordet J-P.
Published: May 2024

Tardigrades, microscopic animals found in virtually all ecosystems, are renowned for their remarkable ability to withstand extreme conditions. Recent studies have identified novel tardigrade specific protein families that aid in resistance to desiccation and ionizing radiation (IR). Notably, a tardigrade specific DNA binding protein called Dsup (for DNA damage suppressor) has been found to protect from X-ray damage in human cells and from hydroxyl radicals
in vitro
. However, Dsup has only been found in two species within the Hypsibioidea superfamily.To better understand mechanisms underlying radio-resistance in the Tardigrada phylum, we first characterized DNA damage and repair in response to IR in the model species
Hypsibius exemplaris
. By analysis of phosphorylated H2AX, we demonstrated the induction and repair of DNA double-strand breaks after IR exposure. Importantly, the rate of single-strand breaks induced was roughly equivalent to that in human cells, suggesting that DNA repair plays a predominant role in the remarkable radio-resistance of tardigrades. In order to identify novel tardigrade specific genes involved, we next conducted a comparative transcriptomics across three species,
H. exemplaris
,
Acutuncus antarcticus
and
Paramacrobiotus fairbanksi
, the latter belonging to the Macrobiotoidea superfamily known to lack Dsup homologs. In all three species, many genes of DNA repair were among the most strongly overexpressed genes alongside a novel tardigrade specific gene, named
T
ardigrade
D
NA damage
R
esponse protein
1
(TDR1). We found that TDR1 protein interacts with DNA and forms aggregates at high concentration suggesting it may condensate DNA and act by preserving chromosome organization until DNA repair is accomplished. Remarkably, when expressed in human cells, TDR1 improved resistance to Bleomycin, a radiomimetic drug. Based on these findings, we propose that TDR1 is a novel tardigrade specific gene responsible for conferring resistance to IR. Our study sheds light on mechanisms of DNA repair helping to cope with high levels of DNA damage. Furthermore, it suggests that at least two tardigrade specific genes, respectively for Dsup and TDR1, have independently evolved DNA-binding functions that contribute to radio-resistance in the Tardigrada phylum.
Unveiling neoadjuvant chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing
Authors: Huang Yiwei , Cheng Lin , Bi Guoshu , Liang Jiaqi , Li Ming , Zhang Huan , Shan Guangyao , Hu Zhengyang , Chen Zhencong , Wu Gujie , Lin Zongwu , Jiang Wei , Wang Qun , Xi Junjie , Zhan Cheng , Yin Shanye
Published: May 2024

Neoadjuvant chemotherapy has emerged as a significant therapeutic approach in the management of lung cancer, aiming to improve outcomes through preoperative systemic treatment. However, the mechanisms underlying treatment efficacy and resistance remain largely unknown. In this study, scRNA-seq analysis of tumor samples from nine lung adenocarcinoma (LUAD) patients, including four with surgery alone and five with neoadjuvant chemotherapy, was conducted. Additionally, a series of in vitro and in vivo assays, encompassing flow cytometry, immunofluorescence, seahorse assay, and tumor xenograft models, were employed to validate our findings. A total of 83,622 cells were analyzed, revealing high heterogeneity in cell type composition across different groups. Functional enrichment analysis uncovered significant metabolic reprogramming induced by chemotherapy in both tumor cells and macrophages. Notably, two macrophage subtypes were identified: Anti-mac cells (CD45+CD11b+CD86+) and Pro-mac cells (CD45+CD11b+ARG+), with the proportion of Pro-mac cells significantly increasing in LUAD tissues after neoadjuvant chemotherapy. Pro-mac cells were found to promote tumor growth and angiogenesis while suppressing tumor immunity. Furthermore, analysis of T and B cell remodeling induced by neoadjuvant therapy revealed a more robust immune cytotoxic response against tumor cells. Our investigation illuminates the intricate metabolic reprogramming occurring within the TME of LUAD in response to neoadjuvant chemotherapy. Specifically, our study highlights the discernible impact on the composition and functionality of immune cells, notably macrophages and T cells. These insights not only deepen our understanding of the nuanced interactions within the TME but also open avenues for the development of novel targeted therapeutic interventions for LUAD.
Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states
Authors: Balasubramanian Revathi , Kizhatil Krishnakumar , Li Taibo , Tolman Nicholas , Bhandari Aakriti , Clark Graham , Bupp-Chickering Violet , Kelly Ruth A , Zhou Sally , Peregrin John , Simón Marina , Montgomery Christa , Stamer W Daniel , Qian Jiang , John Simon WM
Published: May 2024

Schlemm’s canal (SC) is central in intraocular pressure regulation but requires much characterization. It has distinct inner and outer walls, each composed of Schlemm’s canal endothelial cells (SECs) with different morphologies and functions. Recent transcriptomic studies of the anterior segment added important knowledge, but were limited in power by SEC numbers or did not focus on SC. To gain a more comprehensive understanding of SC biology, we performed bulk RNA sequencing on C57BL/6 J SC, blood vessel, and lymphatic endothelial cells from limbal tissue (~4,500 SECs). We also analyzed mouse limbal tissues by single-cell and single-nucleus RNA sequencing (C57BL/6 J and 129/Sj strains), successfully sequencing 903 individual SECs. Together, these datasets confirm that SC has molecular characteristics of both blood and lymphatic endothelia with a lymphatic phenotype predominating. SECs are enriched in pathways that regulate cell-cell junction formation pointing to the importance of junctions in determining SC fluid permeability. Importantly, and for the first time, our analyses characterize three molecular classes of SECs, molecularly distinguishing inner wall from outer wall SECs and discovering two inner wall cell states that likely result from local environmental differences. Further, and based on ligand and receptor expression patterns, we document key interactions between SECs and cells of the adjacent trabecular meshwork (TM) drainage tissue. Also, we present cell type expression for a collection of human glaucoma genes. These data provide a new molecular foundation that will enable the functional dissection of key homeostatic processes mediated by SECs as well as the development of new glaucoma therapeutics.
Genetic Stability of Mycobacterium smegmatis under the Stress of First-Line Antitubercular Agents: Assessing Mutagenic Potential
Authors: Molnár Dániel , Surányi Éva Viola , Trombitás Tamás , Füzesi Dóra , Hirmondó Rita , Tóth Judit
Published: May 2024

The sustained success of
Mycobacterium tuberculosis
as a pathogen arises from its ability to persist within macrophages for extended periods and its limited responsiveness to antibiotics. Furthermore, the high incidence of resistance to the few available antituberculosis drugs is a significant concern, especially since the driving forces of the emergence of drug resistance are not clear. Drug-resistant strains of
Mycobacterium tuberculosis
can emerge through
de novo
mutations, however, mycobacterial mutation rates are low. To unravel the molecular mechanisms of antibiotic pressure on genetic variability and their impact on mycobacterial survival, we systematically explored the effects of current antibiotics on genome stability, DNA repair system activation, and the dNTP pool using
Mycobacterium smegmatis
. Whole-genome sequencing revealed no significant increase in mutation rates after prolonged exposure to first-line antibiotics. However, the phenotypic fluctuation assay indicated rapid adaptation to antibiotics, likely mediated by non-genetic factors. The upregulation of DNA repair genes measured using qPCR suggests that genomic integrity is maintained through the activation of specific DNA repair pathways. Our results, indicating that antibiotic exposure does not result in
de novo
adaptive mutagenesis under laboratory conditions, do not lend support to the model suggesting antibiotic resistance development through drug pressure-induced microevolution.
INNOVACIÓN DOCENTE: PERSPECTIVA DEL ROL DOCENTE DE ENFERMERIA EN SIMULACIÓN CLÍNICA EN URGENCIAS
Authors: Urrutia Arroyo Ruth , Troncoso González Blanca , Baeza Fuentes Margarita
Published: May 2024

INTRODUCCIÓN: En el curso académico 2019 se incorporó la simulación clínica dentro de la asignatura de Enfermería en Urgencias en cuarto año, previo a la práctica profesional (Universidad de Santiago de Chile). Se integró como herramienta de innovación docente que favorece el cambio a una formación centrada en el estudiante fortaleciendo en la adquisición de competencias clínicas. OBJETIVO: Comprender la experiencia de docentes en la formación en simulación clínica de alta fidelidad en la asignatura de urgencias con estudiantes de enfermería de cuarto año. METODOLOGÍA: Estudio descriptivo cualitativo desarrollado con 3 docentes que imparten la asignatura de urgencias en una universidad pública de Chile. Se utilizó la técnica de entrevistas en profundidad para la recolección de la información. Para la sistematización y análisis se utilizó la técnica de análisis de contenido. RESULTADOS: El análisis permitió descubrir los siguientes temas: la valoración global acerca de la simulación clínica, la experiencia acerca del nuevo rol docente en simulación, tensiones y desafíos de la implementación. CONCLUSIÓN: El estudio evidenció que uno de los desafíos fundamentales de la simulación clínica es la transformación en el rol tradicional del docente en la formación de enfermería lo cual tiene que ver directamente con la capacitación específica en simulación. Los resultados proporcionan información relevante acerca de lo que podría ayudar a mejorar esta propuesta pedagógica sea implementada con docentes de las demás disciplinas como una etapa previa a su desarrollo en la formación de pregrado en enfermería, promoviendo en los estudiantes una mayor participación y responsabilidad en la gestión de su aprendizaje.
Modelagem e otimização do sistema de atendimento de um restaurante baseado em Teoria de Filas
Authors: Picanço Ailson Renan Santos , Sousa Ana Maria Almeida , Ribeiro Hebe Morganne Campos , Veras Maria Eduarda dos Santos Carreiro , Lopes Matheus Oliveira , Prado Maycon Cruz do
Published: May 2024

O artigo analisa o sistema de formação de filas em um restaurante localizado no sudeste do Pará, com o objetivo de avaliar a eficiência do atendimento e identificar possíveis gargalos. A teoria das filas é utilizada como uma ferramenta para compreender o comportamento do sistema e propor melhorias no arranjo produtivo. A metodologia, fundamentalmente de base quantitativa, adotada envolve a coleta de dados relacionados à chegada dos clientes na fila, tempo de atendimento e tempo de recebimento da marmita, seguido pela análise estatística desses dados. Os resultados obtidos permitem avaliar o desempenho do restaurante em medição como tempo médio de espera na fila, taxa de ocupação do servidor e tempo médio no sistema. Com base nessas análises, são identificados pontos de melhoria, como a segmentação das filas e o uso de placas de aviso para diferenciar os tipos de atendimento oferecidos. Essas sugestões visam otimizar o processo de atendimento, reduzir o tempo de espera dos clientes e proporcionar uma melhor experiência no restaurante.
A violência contra as mulheres como determinante de saúde: estudo de casos (síndromes depressivas e ansiosas)
Authors: Ferreira Mário Wesley , Richter Tamara Tomitan , Marques Fernanda Hoffmann , Jorge Bianca Stefany Dias de , Ruiz Amanda Ricci , Silva Tânia Maria Gomes da
Published: May 2024

A violência contra as mulheres atua como fator de risco e fator etiológico no desenvolvimento de patologias, principalmente transtornos psiquiátricos. O objetivo deste artigo é identificar e descrever qualitativamente como a violência de gênero prejudicou a saúde de cinco mulheres. O estudo consistiu na abordagem descritiva e comparativa das narrativas das vítimas sobre os episódios de violência experimentado, bem como os sinais, sintomas e condição de saúde apresentada após as agressões sofridas. Foi identificado que a violência contra mulher influenciou negativamente na saúde das voluntárias entrevistadas, através de associações diretas e indiretas no desenvolvimento de doenças. As entrevistadas manifestaram injúrias agudas e crônicas, com destaque para os transtornos depressivos e ansiosos. Portanto, foi concluído que o enfrentamento da violência contra mulher deve ser compreendido como medida de prevenção de doenças, promoção de saúde e qualidade de vida.
Gestão pública e terceiro setor: uma solução de sustentabilidade e resiliência no sistema de saúde público brasileiro
Authors: Barbosa Fernando Campos , Ferreira Danilo Lacerda de Souza , Tadine Rodrigo Martins , Rezende Janaina Drawanz Pereira , Lopes Gabriel César Dias , Silva Alandey Severo Leite da , Catapan Anderson
Published: May 2024

Objetivos: Este estudo tem como objetivo analisar a contribuição da gestão pública e do terceiro setor para promover sustentabilidade e resiliência no sistema de saúde público brasileiro. No sistema de saúde atual, o Estado enfrenta desafios ao alocar recursos sem retorno econômico direto. Houve uma evolução na administração pública ao reconhecer suas falhas e optar pela descentralização das atividades para o "terceiro setor", formado por entidades privadas sem fins lucrativos ou filantrópicas. Essas entidades desempenham um papel importante ao ajudar o poder público a normalizar os serviços de saúde e promover o bem comum. São analisados pontos-chave relacionados a esse tema para entender melhor seu impacto e benefícios. Material e Métodos: Este trabalho foi feito após uma pesquisa extensiva em várias bases de dados, como Medline, Science Direct, Pubmed, Scielo, Lilacs e Google Acadêmico, sem um período específico de referência. Foram utilizadas palavras-chave como "Gestão Pública", "Terceiro Setor", "Sustentabilidade", "Resiliência", "Sistema de Saúde Público Brasileiro" e suas equivalentes em inglês, de forma isolada ou combinada, sem restrição temporal. Por meio de uma revisão narrativa e análise bibliográfica, os dados foram sintetizados de forma descritiva para compilar o conhecimento sobre o tema. Resultados: A colaboração entre a gestão pública e o terceiro setor tem desempenhado um papel significativo na promoção da sustentabilidade e resiliência no sistema de saúde público brasileiro. A atuação conjunta tem possibilitado a ampliação do acesso a serviços de saúde, a otimização dos recursos disponíveis e o desenvolvimento de iniciativas inovadoras para enfrentar desafios emergentes. Conclusão: A parceria entre a gestão pública e o terceiro setor é uma solução viável e eficaz para fortalecer o sistema de saúde público no Brasil. A cooperação estratégica, pautada na transparência, eficiência e participação social, contribui para a melhoria contínua dos serviços de saúde, tornando o sistema mais sustentável e resiliente diante das demandas e adversidades enfrentadas.
Effect of Sildenafil in Neonates with Persistent Pulmonary Hypertension: An Interventional Study
Authors: Jain Jigar , Vaishnav Jolly , Vohra Arif , Shah Mansi , Goyal Anika
Published: May 2024

Introduction: Persistent Pulmonary Hypertension of the Newborn (PPHN) reflects a disruption of the normal perinatal circulatory transition and is characterised by high pulmonary artery pressure. Inhaled Nitric Oxide (iNO) is considered the mainstay of treatment for PPHN. However, many developing and resource limited countries do not have access to such expensive therapy. Therefore, sildenafil, due to its easy availability and low cost, becomes the most commonly used drug in the management of PPHN in such settings. Aim: To study the treatment response and outcomes of neonates who received sildenafil for the management of PPHN. Materials and Methods: The present hospital-based prospective interventional study was conducted in the Neonatal Intensive Care Unit (NICU), BJ Medical College, Civil Hospital, Ahmedabad, Gujarat, between May 1, 2020, and April 30, 2021. Study was conducted on neonates with meconium aspiration syndrome and/or severe birth asphyxia admitted to the NICU. A total of 48 neonates with Two Dimensional (2D) echocardiography-proven PPHN were enrolled. Baseline clinical parameters including heart rate, respiratory rate, preductal and postductal Saturation of Peripheral Oxygen (SpO2), Oxygenation Index (OI), Saturation Oxygen Distending Pressure Index (SOPI), and Non Invasive Blood Pressure (NIBP) were monitored every six hours. Neonates who were on invasive/ non invasive ventilation had their Fraction of Inspired Oxygen (FiO2), Positive End Expiratory Pressure (PEEP), Peak Inspiratory Pressure (PIP), respiratory rate and flow rate monitored every six hours. Data were statistically analysed using Analysis of Variance (ANOVA) test. Results: During the study period, a total of 1080 neonates were admitted with meconium aspiration syndrome and/or severe birth asphyxia, out of which 48 neonates showed findings suggestive of PPHN on 2D echocardiography. A statistically significant improvement in oxygenation after sildenafil treatment was indicated by a significant reduction in OI from 35.3±8.6 to 13.2±2.1 (p-value<0.001), a reduction in SOPI from 3.6±0.3 to 1.5±0.2 (p-value<0.001), a reduction in FiO2 (%) from 94.6±8.19 to 24.2±4.5 (p-value<0.001), an increase in Partial pressure of oxygen (PaO2) (mmHg) from 52±5.6 to 72±3.4 (p-value<0.001), and an increase in SpO2 (%) from 83.5±8.6 to 93.5±5.1 (p-value<0.001). Conclusion: The findings of the present study suggest that oral sildenafil can be successfully used to improve oxygenation in patients with PPHN, especially in a resource limited setting where facilities like Extracorporeal Membrane Oxygenation (ECMO) and iNO are not available, as demonstrated in the present study.
Comparative Study of Synthetic Insecticides with Biopesticides against Spotted Stem Borer, Chilo partellus (Swinhoe) on Maize (Zea mays L.)
Authors: Garhwal Abhishek , Yadav Usha
Published: May 2024

Spotted stem borer, Chilo partellus (Lepidoptera: Pyralidae) regarded as one of the most significant and prevalent insect pests of maize and its mystic aspect of feeding makes it challenging to control. Hence current study aims to evaluate comparative study of synthetic insecticides with biopesticides against Chilo partellus. Eight treatments viz., azadirachtin 10,000ppm, neem oil 3%, karanj oil 3%, neem oil 3% + imidacloprid 17.5%SL, karanj oil 3% + imidacloprid 17.5%SL, imidacloprid 17.5%SL, spinosad 45%SC and untreated control were tested under field condition in randomized block design with three replications. Among the treatments, lowest larval population of Chilo partellus per plant were recorded in karanj oil 3% + imidacloprid 17.5%SL (1.99) followed by neem oil 3% + imidacloprid 17.5%SL (2.42), imidacloprid 17.5%SL (2.71), spinosad 45%SC (3.17), neem oil 3% (3.73), karanj oil 3% (3.95) and azadirachtin 10,000ppm (4.44) were found superior over the untreated control (7.24). The highest yield was recorded in karanj oil 3% + imidacloprid 17.5%SL with 39.20 q/hectare and most economic treatment was imidacloprid 17.5%SL with highest cost benefit ratio (1:2.2). The lowest cost benefit ratio was recorded in untreated control (1:1.4).
Information Communication and Technology Resource Availability and Integration in Instruction among Secondary Schools in Habaswein Sub-county
Authors: Nadhif Kusow M. , Warfa Ahmed Osman , Mumo Rosalia Mwikali
Published: May 2024

Incorporation of Information, Communication and Technology (ICT) in learning has been established as crucial for enabling teachers to replace traditional methods of teaching with technology-enabled education facilities. In Kenya, under vision 2030, ICT is deemed to be among the key elements essential for transforming the nation’s development. The Ministry of Education, through the Education Blue print dated 2013-2025, highlights the essence of technology-aided teaching and learning in the school’s national curriculum. This study aims to examine the availability of instructional ICT resources in government secondary schools in Habaswein sub-county Descriptive survey design was employed in this study. The study targeted nine secondary schools in the region. Piloting of study was carried out in Sarif Mixed Day Secondary School within Habaswein Sub-County. Data was gathered using semi-structured interviews and questionnaire to allow the respondents present their unbound views about the issue being explored. The qualitative data collected was analyzed using thematic data analysis method while quantitative data obtained was analyzed using SPSS. The study concludes that information communication and technology resource availability has a significant association (r = 0.644, p<.001) with ICT integration in instructions. The study recommends for provision of adequate ICT resources for effective ICT integration in in instructions in public secondary schools in Habaswein Sub- County.
Therapeutic Values of Essential Oils
Authors: Rajput Reshu , Kour Anchit , Sabina .
Published: May 2024

Essential oils (EO) are highly concentrated chemicals extracted from leaves, stems,seeds, roots, flowers, resins, and barks. It has been illustrated that essential oils derived from clove, lemon, fennel, eucalyptus, teatree, lavender, peppermint, rosemary have preventive effects on bacteria, fungi and viruses; various studies have been done to evaluate the usefulness of essential oils against microorganisms. Extraction of essential oil from the raw materials is the most time consuming process. There are various methods that are used in extraction of essential oils that are Steam distillation, hydrodistillation, solvent extraction, cold pressing, enfleurage. The combined effects of EO-EO or Essential oil- antibiotic show higher efficacy, according to the strategy of combinatory effects via conventional and non- traditional means. This paper focuses on the various therapeutic uses of essential of different kinds like Peppermint EO, Clove EO, Rosemary EO, Lemon EO etc. Various properties of EO have been mentioned, including anti-diabetic, anti-fungal, anti-mutagenic, anti-viral, anti-viral, anti-bacterial, anti-inflammatory and cancer curing. EO is composed of different components which consists of alcohol, phenol, aldehyde,  ketone, terpenoids and ester. Along with beneficial and therapeutic values of EO there also comes some limitations. EO is very useful and is considered as a futuristic approach for clinical operations.
Impact of Mechanized Crop Establishment Techniques on Growth, Yield, and Microbial Dynamics under Rice-Wheat Cropping System: A Review
Authors: Unjia Denil , Korav Santosh , Banik Biswajyoti , Guin Aritra
Published: May 2024

The rice-wheat cropping system, predominant across the Indo-Gangetic plains, generates a substantial volume of crop residue, with an annual yield of 7-9 tonnes per hectare of rice residue. Effective management of this residue, whether in-situ or ex-situ, has become an urgent necessity. However, the economic feasibility of transporting residue beyond 20 km from the field is limited. Consequently, in-field residue management through the adoption of specialized machinery has emerged as an imperative solution. The narrow window between paddy harvesting and wheat sowing, compounded by labor scarcity during peak periods, underscores the need for mechanized crop establishment techniques. Machines such as happy seeders, super seeders, turbo seeders, spatial drills, and seed-cum-fertilizer drills are crucial tools in this regard. This paper examines the benefits of mechanized crop establishment techniques on wheat growth, productivity, and soil biological health within the rice-wheat cropping system. These techniques have revolutionized agricultural practices by significantly influencing growth dynamics, yield parameters, and microbial ecology. The adoption of precision seed drills and mechanized tillage equipment has transformed traditional farming methods, facilitating efficient seed placement, soil preparation, residue incorporation, and weed management. This has resulted in improved crop growth parameters, enhanced yield dynamics, better root development, increased nutrient uptake, and overall plant vigor. Furthermore, reduced soil disturbance and decreased weed pressure associated with mechanized operations have created a conducive environment for beneficial microbial communities to thrive. The integration of mechanized crop establishment techniques has a positive impact on both crop productivity and sustainability, highlighting their importance in modern agricultural practices within the rice-wheat cropping system of the Indo-Gangetic plains.
Evaluation of Reproductive and Growth Performance in New Breeds and Hybrids of Bivoltine Silkworm (Bombyx mori L.)
Authors: D Thrilekha, , Gowda Manjunatha , G.D Pradip , Mala P. Harshita , D.S Chethankumar , Seetharamulu J.
Published: May 2024

This study aimed to evaluate the reproductive and growth performance of recently developed bivoltine silkworm parental breeds and their hybrids to improve silk production and ensure the long-term sustainability of sericulture. Utilizing five thermotolerant pure breeds (B1, B2, B4, B6 and B8) and four popular CSR breeds (CSR2, CSR27, CSR6 and CSR26), six foundation crosses and eight double hybrids were developed and evaluated for ten traits. Results showed that B1 exhibited superior performance in fecundity (524.00), hatching percentage (98.67%), dead eggs (1.33%), pupal weight (1.31 g), pupation rate (96.84%) and cumulative survival index (CSI) (93.84%). The foundation cross B1 × B2 excelled in fecundity (553.67), larval mortality (2.67%), pupal weight (1.53 g), ERR (97.33%) and CSI (93.27%) while FC2 performed better in hatching percentage (97.60%), dead eggs percentage (2.40%), fifth instar larval duration (157.21 h), fifth instar larval weight (35.64 g/10 larvae) and pupation rate (96.33%). Among the double hybrids, (B1 × B2) × (FC1) demonstrated superior performance in fecundity (614.33), larval mortality (1.41%), pupal weight (2.06 g), ERR (98.59%) and CSI (97.24%). FC2 × FC1 excelled in larval duration (141.11 h), fifth instar larval weight (51.96 g/10 larvae) and pupation rate (98.94%). Double hybrids showed significant improvements compared to parental breeds and foundation crosses, indicating potential for field testing and further development. These results indicate the potential of using the newly identified breeds and foundation crosses in silkworm breeding, particularly in developing new double hybrids as an alternative to established CSR breeds and hybrids.
ChemInform Abstract: Long‐Lasting Phosphorescence of Transparent Surface‐Crystallized Glass‐Ceramics.
Authors: Fu Jie
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Heat Capacity of NaNO3(aq) in Stable and Supercooled States. Ion Association in the Supercooled Solution.
Authors: Carter Richard W. , Archer Donald G.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preparation of Anodes for Oxygen Evolution by Electrodeposition of Composite Oxides of Pb and Ru on Ti.
Authors: Bertoncello Renzo , Cattarin Sandro , Frateur Isabelle , Musiani Marco
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Characterization of Nanocrystalline Lanthanide Oxysulfide via a La(OH)3 Gel Solvothermal Route.
Authors: Jiang Yang , Wu Yue , Xie Yi , Qian Yi‐Tai
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Cyanide‐Bridged Chain of Mo6Se8 Clusters: A Product of Cyanide‐Melt Cluster Synthesis.
Authors: Magliocchi Carmela , Xie Xiaobing , Hughbanks Timothy
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Astemizole Tetrachlorocuprate(II).
Authors: Parvez Masood , Braitenbach Kristin
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Three Methoxy‐Substituted Diethyl 2‐Phenyl‐2,6‐dimethyl‐1,4‐dihydropyridine‐3,5‐dicarboxylate Compounds.
Authors: Metcalf Sara K. , Holt Elizabeth M.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 4‐(N‐Hydroxyethyl‐N‐methylamino)benzaldehyde Thiosemicarbazone.
Authors: Shanmuga Sundara Raj S. , Fun Hoong‐Kun , Zhang Xuan‐Jun , Tian Yu‐Peng , Xie Fu‐Xin , Ma Ji‐Long
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 2,4‐Bis(o‐tolyl)‐3‐azabicyclo[3.3.1]nonan‐9‐one.
Authors: Vijayalakshmi L. , Parthasarathi V. , Venkatraj M. , Jeyaraman R.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Multicenter Hydrogen Bonds in a 2:1 Arylsulfonylimidazolone Hydrochloride Salt.
Authors: Park Kyung‐Lae , Moon Byoung‐Gi , Jung Sang‐Hun , Kim Jin‐Gyu , Suh Il‐Hwan
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: (5S)‐3‐Oxo‐4‐oxa‐endo‐tricyclo[5.2.1.02,6]dec‐8‐en‐5‐yl Acetate.
Authors: Ellis Dianne D. , Spek Anthony L.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 2,4,6‐Trichlorophenylisonitrile and 2,4,6‐Trichlorobenzonitrile.
Authors: Pink Maren , Britton Doyle , Noland Wayland E. , Pinnow Matthew J.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Inhibitor of Janus Kinase 3. 4‐(4‐Hydroxyphenylamino)‐6,7‐dimethoxyquinazolin‐1‐ium Chloride Methanol Solvate.
Authors: Sudbeck Elise A. , Jennissen Jason D. , Liu Xing‐Ping , Uckun Fatih M.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereocontrol in Rare Earth Metal Triflate‐Catalyzed 1,3‐Dipolar Cycloaddition Reaction of 2‐Benzopyrylium‐4‐olate with Aldehydes.
Authors: Suga Hiroyuki , Kakehi Akikazu , Ito Suketaka , Inoue Kei , Ishida Hajime , Ibata Toshikazu
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Novel Counterion Effect on the Diastereoselectivity in the MnIII(Salen)‐Catalyzed Epoxidation of Phenyl‐Substituted cis‐Alkenes.
Authors: Adam Waldemar , Roschmann Konrad J. , Saha‐Moeller Chantu R.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Homologation of Boronic Esters Bearing Azido and Silyloxy Substituents.
Authors: Singh Rajendra Prasad , Matteson Donald S.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Catalytic Asymmetric Oxidation of Sulfides to Sulfoxides Mediated by Chiral 3‐Substituted‐1,2‐benzisothiazole 1,1‐Dioxides.
Authors: Bethell Donald , Page Philip C. Bulman , Vahedi Hooshang
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Unique Regio‐ and Stereoselectivity in Pd‐Catalyzed Chlorocarbonylation Reaction of 2‐Phenylethynyl Selenides and 2‐Alkylethynyl Selenides. Highly Stereoselective Synthesis of 2‐Seleno‐3‐chloroacrylates.
Authors: Huang Xian , Sun Aiming
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reaction of Some Alkenols with Tetrachloromethane.
Authors: Bugarcic Zorica M. , Mojsilovic Biljana , Marjanovic Ljiljana , Konstantinovic Stanimir
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Radical‐Initiated, Skeletal Rearrangements of Bicyclo[2.2.2] Lactones.
Authors: Marko Istvan E. , Warriner Stuart L. , Augustyns Benoit
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Iodination of Aromatic Compounds with Iodine Monochloride in Aqueous Sulfuric Acid.
Authors: Chaikovskii V. K. , Filimonov V. D. , Kharlova T. S. , Chernova T. N. , Sharapova E. S.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Approach for the Chemoselective Debromination of Chiral Bromohydrins. Toward the Development of a Very General Approach to Enantiopure α‐Unsubstituted β‐Hydroxy Acids.
Authors: Wang Ying‐Chuan , Yan Tu‐Hsin
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Facile and Rapid Regeneration of Carbonyl Compounds from Their N,N‐Dimethylhydrazones by Employing Transition Metal Complexes.
Authors: Kamal Ahmed , Arifuddin M. , Rao Maddamsetty V.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: KO2/Crown Ether: A Novel Catalytic System for the Hydrosilation and Tishchenko Reaction of Aromatic Aldehydes.
Authors: Le Bideau Franck , Coradin Thibaud , Gourier Didier , Henique Josette , Samuel Edmond
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Thiol Ester—Boronic Acid Cross‐Coupling. Catalysis Using Alkylative Activation of the Palladium Thiolate Intermediate.
Authors: Savarin Cecile , Srogl Jiri , Liebeskind Lanny S.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: NiCl2/CrCl2/Mn‐Mediated Homocoupling of Aryl Halides Accomplished in the Presence of Bipyridyl‐Type Ligand.
Authors: Chen Chinpiao
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Efficient Synthesis of Enantiopure 3‐Chlorostyrene Oxide via Oxazaborolidine‐Catalyzed Reduction.
Authors: Choi Ok Kyoung , Cho Byung Tae
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: N‐[1‐(2‐Phenylethyl)pyrrolidin‐3‐yl]‐1‐adamantanecarboxamides as Novel 5‐HT2 Receptor Antagonists.
Authors: Fujio Mazakazu , Kuroita Takanobu , Sakai Yoko , Nakagawa Haruto , Matsumoto Yasuhiro
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Regioselective Synthesis of Unsymmetrical 3,5‐Dialkyl‐1‐arylpyrazoles.
Authors: Wang Xiao‐jun , Tan Jonathan , Zhang Li
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reaction of N‐[(Trimethylsilyl)methyl]carbodiimides with Bifunctional Nucleophiles.
Authors: Tsuge Otohiko , Hatta Taizo , Shinozuka Masanori , Tashiro Hideki , Maeda Hironori , Kakehi Akikazu
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Improved Synthesis of 1,2,4‐Triazoles Using Ag2CO3.
Authors: Paulvannan K. , Chen Tao , Hale Ron
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Transformations of Alkyl 1,5‐Bis(dimethylamino)‐3‐oxopenta‐1,4‐diene‐2,4‐dicarboxylates. A Simple Synthesis of Dialkyl 1‐Substituted 4‐Oxo‐1,4‐dihydropyridine‐3,5‐dicarboxylates.
Authors: Zupancic Silvo , Svete Jurij , Stanovnik Branko
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Formation of Isoquinoline Derivatives by the Irradiation of N‐Acetyl‐α‐dehydrophenylalanine Ethyl Ester and Its Derivatives.
Authors: Hoshina Hideki , Tsuru Hitoshi , Kubo Kanji , Igarashi Tetsutaro , Sakurai Tadamitsu
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective Synthesis of (7R,8R,8aR)‐ and (7S,8S,8aS)‐7‐Hydroxy‐8‐indolizidinemethanol by 1,3‐Dipolar Cycloaddition of 1‐Pyrroline N‐Oxide to Chiral Pentenoates.
Authors: Cordero Franca Maria , Faggi Cristina , De Sarlo Francesco , Brandi Alberto
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereoselective Transacetalization of 1,1,3,3‐Tetramethoxypropane and N‐Benzoylaminodiols.
Authors: Bi Lanrong , Zhao Ming , Wang Chao , Peng Shiqi
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Studies on Pyrimidine‐Annulated Heterocycles: Synthesis and Dynamic Properties of [n](2,4)‐Pyridinophanes (n = 11, 9, 8, 6).
Authors: Yamamoto Hiroyuki , Takeda Hidekazu , Nitta Makoto
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Phenazine 5,10‐Dioxides from Benzofuroxan Catalyzed by Molecular Sieves.
Authors: Takabatake Tohru , Miyazawa Tomoyuki , Kojo Mahiro , Hasegawa Minoru
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Characterization of p‐tert‐Butylcalix[6]‐1,4‐crown‐4‐2,6‐crown‐5, p‐tert‐Butylcalix[6]‐1,4‐benzocrown‐4‐2,3‐crown‐5.
Authors: Chen Yuan‐Yin , Li Hai‐Bing
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Macrocyclic Compounds: Synthesis of Various 6,15‐Dithia‐2,3,8,11,12,17,19,20‐octaazatricyclo [14.2.1.17,16]eicosa‐1,7(20),10,16(19)‐tetraene‐4,13‐dione Derivatives Having Potential Antitumor Activity.
Authors: Ismail Mohamed Abdel Hamid
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Aromatic Nucleophilic Substitution in Pentafluoropyridine by Three‐Coordinate Phosphorus Compounds.
Authors: Veits Yu. A. , Karlstedt N. B. , Chuchuryukin A. V. , Beletskaya I. P.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.