bluuebunny/crossref_metadata_2025 huggingface dataset:
Significance of Data Structures and Data Retrieval Techniques on Sequence Rule Mining Efficacy
Authors: Nayanjyoti Mazumdar Et al.
Published: December 2023

Sequence mining intends to discover rules from diverse datasets by implementing Rule Mining Algorithms with efficient data structures and data retrieval techniques. Traditional algorithms struggle in handling variable support measures which may involve repeated reconstruction of the underlying data structures with changing thresholds. To address these issues the premiere Sequence Mining Algorithm, AprioriAll is implemented against an Educational and a Financial Dataset, using the HASH and the TRIE data structures with scan reduction techniques. Primary idea is to study the impact of data structures and retrieval techniques on the rule mining process in handling diverse datasets. Performance Evaluation Matrices- Support, Confidence and Lifts are considered for testing the efficacies of the algorithm in terms of memory requirements and execution time complexities. Results unveil the excellence of Hashing in tree construction time and memory overhead for fixed sets of pre-defined support thresholds. Whereas, TRIE may avoid reconstruction and is capable of handling dynamic support thresholds, leading to shorter rule discovery time but higher memory consumption. This study highlights the effectiveness of Hash and TRIE data structures considering the dataset characteristics during rule mining. It underscores the importance of appropriate data structures based on dataset features, scanning techniques, and user-defined parameters.
Classification and Prediction Evaluation of a Fuzzy Rule-Based Model for Diabetes Diagnosis, Level of Care and Pima Indians Diabetes Datasets
Authors: Teh Noranis Mohd Aris Et al.
Published: December 2023

— Classification and prediction of diseases is crucial in decision-making for the healthcare sectors, especially diabetes, a chronic disease. The availability and accessibility of diabetes datasets assists medical practitioners in the diagnosis process as well as researchers in various fields and these datasets are valuable sources. However, diabetes datasets are exposed to vagueness and uncertainty issues. This research work improved an interrelated decision-making model for diabetes by proposing a fuzzy rule-based model to handle the vagueness and uncertainty issues. The research methodology starts with pre-processing of the simulated diabetes diagnosis and level of care datasets that were validated by medical experts, as well as the Pima Indians Diabetes Dataset (PIDD). This is followed by the design of the fuzzy model and the construction of the fuzzy rules. Next, the testing of the fuzzy model using six supervised machine learning algorithms namely J48, Logistic, Naive Bayes Updateable, Random Tree, Bayes Net and AdaBoostM1. Lastly, the evaluation of the fuzzy model in terms of the accuracy, precision, recall, F1-Score and confusion matrix. Experimental results show 100% accuracy for the diabetes diagnosis fuzzy model, for all the five machine learning algorithms mentioned except AdaBoostM1 with 79.8165% accuracy. In addition, for the level of care fuzzy model, the highest accuracy produced is 97.1098% for J48 algorithm and the lowest accuracy is 93.1049% for Naive Bayes Updateable and Bayes Net algorithms. Furthermore, for the PIDD fuzzy model, the highest accuracy obtained is 74.8698% for J48 and AdaBoostM1 algorithms and the lowest accuracy is 70.1823% for Random Tree algorithm. Overall, the proposed fuzzy model produced a good accuracy and working as expected associated to the previous interrelated decision-making model.
Binary Arithmetic Optimization Algorithm with Machine Learning based Intrusion Detection System
Authors: S. P. Senthilkumar, Et al.
Published: December 2023

Intrusion Detection Systems (IDS) are significant for preventing and identifying malicious actions in computer networks. Machine Learning (ML) approaches are extremely executed for recognizing intrusion since it is investigating huge volumes of network traffic data and recognize designs indicative of intrusions. But, the performance of these ML approaches is greatly dependent upon the choice of relevant features which efficiently represent the network traffic data. Feature Selection (FS) is the procedure of recognizing the most informative and discriminative aspects in a given database. As part of Intrusion Detection (ID) utilizing ML, FS purposes for identifying the subset of features that are efficiently differentiated between normal network behaviour and malicious activities. This article proposes a Binary Arithmetic Optimization Algorithm with Machine Learning based Intrusion Detection System (BAOA-MLIDS) technique. The BAOA-MLIDS technique employs FS with an optimal ML classifier for the ID process. To accomplish this, the BAOA-MLIDS technique performs data preprocessing to scale the input data. Besides, the BAOA-MLIDS technique comprises BAOA based FS approach to choose optimal features. Moreover, Extreme Learning Machine (ELM) approach is utilized for the identification of the intrusions. Furthermore, Hunger Games Search Optimization (HGSO) approach was employed for the hyperparameter optimization of the ELM approach. The performance assessment of the BAOA-MLIDS model was examined on a standard dataset and the outputs outperformed the advancement of the BAOA-MLIDS model in the ID process.
Harnessing Nature’s Green Potential: Nanotechnology Driven Fabrication of Plant-Derived Nanoparticles
Authors: Verma Poonam , Kumar Vikas , Dubey Sakshi , Sao Priyanshu , Tiwari Anjali
Published: December 2023

Millions of tons of metallic nanoparticles (MNPs) are synthesized each year and used in various fields like nano-enabled devices, personal care, medicine, food, and agriculture. The reaction chemicals and processes employed in the industrial synthesis of MNPs are well acknowledged to be hazardous to the environment.Green synthesis has been recommended as a means of minimizing the usage of harmful substances and adverse chemical modification in the synthesis of MNPs. Extracts of organic chemicals, microorganisms, plants and plant-derived materials have all been employed as reducing agents in green synthesis.One of the most efficient, easy, cost-effective, and environmentally acceptable techniques for reducing the usage of toxic chemicals is to employ plant extracts in the synthesis of MNPs. Several eco-friendly procedures for the fast production of MNPs have been reported by utilizing aqueous extracts of plant components including the leaf, bark, flower, peel, shoot, tuber, resin, roots etc.Every year, new scientific publications are released, with each one highlighting the advantages of the green methodover classic synthesis. However, over two decades after the preliminary reports about the new technique exploded, commercial production of green-synthesized nanoparticle (NPs) does not appear to have found a means to scale up. This review covers green MNPs synthesis from various plant extracts and their potential applications as antimicrobial agents covering the literaturesince 2015. While highlighting the use of MNPs in a variety of fields and the potential impact of phytochemicals associated in MNPs production.
Preparing Teachers to Use Web Technologies for Independent Professional Development
Authors: Mamit Askarov , Maksetbay Mambetniyazov
Published: December 2023

Explores the evolving landscape of education, emphasizing the imperative for continuous professional development, particularly in the field of pedagogy. It underscores the challenges posed by the rapid advancements in information technologies and the need for educators to adapt through self-education. The discussion encompasses the role of information processes intensification, the impact of global communication, and the necessity for a proactive, open, and accessible education system. The importance of fundamentalization and advanced education principles is highlighted, with a focus on preparing individuals for the dynamic challenges of the 21st century. The text concludes by emphasizing the importance of continuous education, self-education, and the integration of web technologies in shaping the future of teacher training.
Analysis of The Influence of Transformational Leadership and Work Environment on Employee Performance at The Branch Office of Bank Sahabat Sampoerna Jakarta
Authors: Romli S.E.  , Prof. Dr. H. Eeng Ahman  , Prof. Dr. H. Disman  , Dr. Rofi Rofaida S.P.
Published: December 2023

This study aims to analyze the influence of transformational leadership and the work environment on employee performance at Bank Sahabat Sampoerna Jakarta Branch Offices. The method in this study is descriptive quantitative through multiple linear regression analysis with the help of the SPSS Version 26 program. The results showed that transformational leadership partially has a positive and significant effect on employee performance, the work environment partially has a positive and significant effect on employee performance, transformational leadership and the work environment simultaneously has a positive and significant effect on employee performance.
Capacidad innovativa en el departamento de la Guajira-Colombia. Insumos para una política pública de innovación
Authors: Bueno Giraldo Isidro , Ziritt Gertrudis Yackeline , Díaz De Campechano Isabel Cristina
Published: December 2023

Los procesos de innovación que se llevan a cabo en el entramado empresarial de cualquier país contribuyen en gran parte a la inserción competitiva de estos en la economía global, de la misma manera las regiones se mueven en este contexto apalancado algunas veces por modelos de sistemas de innovación, cuya estructura, comportamiento y relaciones reticulares se desarrollan en un contexto regulatorio desde aspectos como el geopolítico, legal, económico y socioeducativo. El objetivo del estudio fue caracterizar la capacidad innovativa en el departamento de la Guajira, en el marco de la normativa jurídica correspondiente, a través de los entornos y componentes clave del Sistema Regional de Innovación, como insumos para una política econó­mica de innovación. Se utilizó el análisis cualitativo, en una investigación documental. Los resultados determinan que el Sistema Regional de Innovación como tal no está consolidado en el departamento de La Guajira; sin embargo, se identificó una estructura identitaria con características propias de la región, que constituye un aporte a la posibilidad de consolidar y fortalecer el sistema con actores del entorno científico, tecnológico, impulsor y productivo. Se concluye resaltando la importancia del diseño de políticas públicas que valoricen la capacidad innovativa del departamento, por lo cual los resultados del estudio se conforman en insumos para una política pública de innovación que permitan el desarrollo local mediante la construcción de conocimiento, innovación empresarial y calidad de los procesos; además de espacios y mecanismos de articulación, que puedan conllevar a la configuración efectiva del Sistema Regional de Innovación.
Influencia del aceite de oliva extra virgen en los niveles de tensión arterial de una población de hipertensos
Authors: Donado Rosales Francisco , Rudas Benítez Vanesa , Bilbao Ramírez Jorge Luis , Parody Muñoz Alexander
Published: December 2023

Objetivo: Determinar la incidencia del consumo de Aceite de Oliva Extra virgen en el nivel de la tensión arterial en pacientes hipertensos. Materiales y métodos: Tipo de estudio: Estudio Experimental modalidad Ensayo Clínico Controlado, mediante la conformación de un Grupo Experimental (50) y un Grupo Control (25). Resultado: Analizándose la incidencia del Aceite de Oliva Extra virgen en los niveles de tensión en los grupos en estudio (experimental – control), se encontró diferencias significativas (p< 0.05) en los cambios en los niveles de Tensión Arterial en el Grupo Experimental en relación con el Grupo Control, resultado que se analizó en relación con las variables:  género y edad. Conclusiones: Luego de la intervención al Grupo Experimental, la tensión arterial presentó una disminución significativa. La Tensión arterial Sistólica disminuyó en 32mmHg y la Tensión Diastólica en 24mmHg; las cifras tensionales del Grupo control no presentaron diferencias. Se evidencia, que, en un periodo de 90 días, el uso de aceite de oliva en los pacientes hipertensos reduce significativamente los valores de la tensión arterial.
Rutas metabólicas intracelulares que intervienen en el desarrollo tumoral en pacientes con síndrome metabólico
Authors: Calonge-Solano Christian Daniel , De La Hoz-Herrera Gustavo Elías , Castilla-Velásquez María Juliana
Published: December 2023

Introducción: el síndrome metabólico se caracteriza por la aparición de signos y síntomas consecuentes a alteraciones metabólicas e inflamatorias a nivel molecular y celular los cuales generan cambios en las diferentes vías de señalización celular mediada por leptina, adiponectina y citoquinas o la activación de cascadas tales como la vía RAS, PI3K/AKT mediada por IGF-1 la cuales contribuyen a proliferación celular descontrolada y desarrollo tumoral. Objetivos: Describir las rutas metabólicas intracelulares de las señales que intervienen en el desarrollo tumoral de pacientes con síndrome metabólico. Métodos: Se realizó una descripción narrativa implementando bases de datos PubMed, Elsevier, Medline y Cochrane de estudios entre 2006 y 2021 que tuvieran como temas central síndrome metabólico, cáncer, obesidad. Se incluyeron artículos en inglés, español y otros idiomas. Resultados: La obesidad es un factor predisponente para múltiples patologías, el estado inflamatorio crónico de aquellos pacientes con IMC >30 kg/ m2 los predispone al desarrollo de neoplasias por alteración en la activación de rutas metabólicas mediadas por citoquinas y hormonas.  Conclusiones: la obesidad, hipertensión arterial, diabetes mellitus y dislipidemias encabezan la lista de las enfermedades crónicas no transmisibles con alta tasa de morbimortalidad a nivel mundial. Se debe tener en cuenta que el síndrome metabólico y la obesidad son factores de riesgo que podrían influir en el desarrollo de tumores.
A Review on the Clinicopathological Features and Management of the Celiac Disease
Authors: Fenglan Wang  , Yonglin Liu  , Shuying Lou  , Xiaoqin Li  , Linna Wang  , Fuyong Jiao  , Md Rezaul Karim  , Abu Taiub Mohammed Mohiuddin Chowdhury
Published: December 2023

Celiac disease (CD) is a multifactorial and chronic autoimmune disease caused by the ingestion of gluten. Epidemiological studies have shown that the disease is currently becoming more common worldwide. Among the countries, North America, North Europe, and Australia have high prevalence of CD. CD is often confused with other chronic gastrointestinal tract-related diseases. Therefore, it is important to have a broad understanding of the clinicopathological features of CD. This review aims to illustrate the epidemiology, pathogenesis, clinical manifestation, and diagnosis and treatment of CD.
Portal Vein Thrombosis is a Potential Complication of Coronavirus Disease 2019 in Cirrhotic Patients
Authors: Alshymaa A. Hassnine
Published: December 2023

Background. According to multiple reports, the incidence of thromboembolic complications has increased in patients infected with coronavirus disease 2019 (COVID-19), particularly in the elderly patients with severe illness and comorbid diseases such as diabetes and hypertension. Portal vein thrombosis (PVT) is a silent and rare venous thromboembolic disease occurring typically in patients with an underlying chronic liver disease, such as decompensated cirrhosis with or without hepatocellular carcinoma (HCC). This study aims to evaluate the incidence of occurrence of acute PVT in cirrhotic patients infected with COVID-19. Methods. This observational study involved 70 cirrhotic patients who were classified into Group A comprising 28 cirrhotic patients infected with COVID19, and Group B comprising 42 age- and sex-matched patients with liver cirrhosis as controls. All patients underwent a thorough medical history and examination. Routine investigations included complete blood count, liver, and renal function tests. Furthermore, imaging techniques such as abdominal and Doppler ultrasonography were used to determine the presence of acute PVT. Levels of serum ferritin, D-dimer, and C-reactive protein were determined, and COVID-19 RT-PCR was conducted for patients of Group A only. Results. Doppler ultrasound examination revealed a significant difference in the number of patients affected by PVT between the two groups. Three patients of Group A (10.7 %) and only one patient of Group B (2.3%) had PVT (P < 0.05).Conclusion. Even in the absence of HCC, PVT could be a potential complication of COVID-19 in cirrhotic patients. Further prospective studies with longer follow-up may be needed for confirmation.
Liver Diseases and Adverse Reactions Induced by Medicinal Herbs and Herb-Drug Interactions
Authors: Mohammad K. Parvez  , Naghma Anjum
Published: December 2023

Integrative medicine encompasses several modalities of complementary and alternative medicine, of which the most relevant is the herbal medicine. Herbal formulations contain multiple pharmacologically active phytochemicals with isolated active compounds usually can achieve better therapeutic performance. In general, herbal medicines are believed to be more effective and safer than prescription drugs. Prescription drugs are approved and licensed only after well regulated clinical trials have been carried out, but a majority of marketed herbal products remain non-regulated without evidence of efficacy and safety. In this article, we review the potential risk of liver diseases or other organ toxicity related to herbs or the combined use of herb and drug. This article also discusses certain medicinal herbs as well as hepatotoxicy and adverse reactions induced by herb-drug interactions in liver disease patients.
Perioperative Nutritional Support by a Multidisciplinary Team for Patients with Esophageal Cancer
Authors: Hiroya Takeuchi  , Ryoma Haneda  , Eisuke Booka
Published: December 2023

Esophageal cancer surgery is a highly invasive procedure, and a multidisciplinary team approach is crucial for safe perioperative management of patients without complications. The Hamamatsu Perioperative Care Team (HOPE) has been established, which is a multidisciplinary team that promotes safer and more reliable perioperative care. HOPE has proven effective in preventing post-esophagectomy pneumonia and weight loss. Currently, HOPE is being developed through comprehensive staff training and the implementation of innovative features, including treatment diaries and wearable fitness trackers. This article explores the benefits of collaborative medical practices and the future objectives of HOPE, whilst also examining the progress of perioperative team medicine in Japan.
Application of multi-window maximum cross-correlation to the mediterranean sea circulation by using MODIS data
Authors: Doronzo Bartolomeo , Taddei Stefano , Brandin Carlo
Published: December 2023

In a previous study an improved Maximum Cross-Correlation technique, called Multi-Window MaximumCross-Correlation (MW-MCC), was proposed, and applied to noise-free synthetic images in order to show its potentialand limits in oceanographic applications. In this work, instead, the application of MW-MCC to high resolution MODISimages, and its capability to provide useful and realistic results for ocean currents, is studied.When applied to real satellite images, the MW-MCC is subject to cloud cover and image quality problems. As a consequence the number of useful MODIS images is greatly reduced. However, for every MODIS image, multiple spectral bands are available, and it is possible to apply the MW-MCC algorithm to the same scene as many times as thenumber of these bands, increasing the possibility of finding valid current vectors.Moreover, the comparison among the results from different spectral bands allows to verify both the consistency ofthe computed current vectors and the validity of using a spectral band as a good tracer for the ocean circulation.Due to the lack of systematic current measurements in the area considered, it has been not possible to perform an extensive error analysis of the MW-MCC results, although a case study of a comparison between HF radar measurementsand MW-MCC data is shown. Moreover, some comparison between numerical ocean model simulations and MW-MCCresults are also shown. The coherence of the resulting circulation flow, the high number of current vectors found, theagreement among different spectral bands, and conformity with the currents measured by the HF radars or simulated byhydrodynamic models show the validity of the technique.
Editorial
Authors: Sheng Jinyu
Published: December 2023

The journal of Satellite Oceanography and Meteorology (SOM) was launched in 2016 for inspiring and disseminating research papers on theory, science, technology and applications of satellite remote sensing data of the ocean, atmosphere and climate. We welcome research papers in areas of (a) original research results from satellite observations of the regional and global ocean and atmosphere, (b) calibration/validation and research related to future satellite missions, and (c) new satellite-derived products and climate records constructed from satellite observations. We also welcome high-quality research papers in broad research areas including but not limiting to (i) oceanography and marine science; (ii) meteorology and atmospheric science; (iii) air-sea, physical-biological and physical-chemical interactions, and (iv) studies of the Earth’s climate system.
Is there any difference in mortality rates of atrial fibrillation detected before or after ischemic stroke?
Authors: Ileri Cigdem , Dogan Zekeriya , Ozben Beste , Midi Ipek , Pazarci Nevin
Published: December 2023

Background and purpose – Atrial fibrillation diagnosed after stroke (AFDAS) is a new term used for AF resulting from autonomic dysregulation. It is associated with a lower stroke recurrence compared to patients with known AF before a stroke (KAF). The aim of the study was to explore the characteristics and mortality rates in AFDAS patients. Methods – 134 ischemic stroke patients (66.1±14.2 years old, n=73 male) were consecutively included in the study. While patients who had known AF with anticoagulant therapy were grouped as KAF, patients with newly documented AF rhythm (either by daily ECG or ambulatory ECG monitoring) were classified as AFDAS. All patients were followed for 1 year to obtain all-cause mortality, cardiac mortality, and neurogenic mortality. Results – Of the 134 stroke patients, AF was detected newly in 38 patients and grouped as AFDAS. KAF patients had higher CHA2DS2VASc scores, hs-CRP and NT-proBNP levels, and more insular cortex involvement than the SR group. During the one-year follow-up, 35 stroke patients died. The mortality rate was significantly higher in patients with KAF (12/22; 54.5%) while the mortality rates were similar between AFDAS patients (11/38; 28.9%) and patients with sinus rhythm (SR) (12/74; 16.2%). KAF was an independent predictor when adjusted by age, sex, CHA2DS2VASc and NIHSS scores, and insular cortex involvement. While AFDAS had increased the mortality risk compared to SR, the difference was not significant in univariable and multivariable models. Conclusion – AFDAS patients have similar CHA2DS2VASc scores and mortality rates to patients with SR, which implies that AFDAS might be a relatively benign form of AF.
Changes in the hippocampal volume in chronic migraine, episodic migraine, and medication overuse headache patients
Authors: Aybakan Mahmut Nedim , Gürsoy Gizem , Pazarci Nevin
Published: December 2023

Background and purpose – Hippocampi are the structures located in the medial depths of both temporal lobes, mainly responsible for memory, navigation and regulation of emotions, and activated during the processing of pain and the modification of nociceptive stimuli. Chronic pain is thought to have stress-like detrimental modulatory effects on the hippocampal neurogenesis, and adults with chronic pain have been showed to have lower hippocampal volumes. The present study aims to show the relationship between headaches and hippocampal volume by comparing the right, left and total hippocampal volumes of patients with Episodic Migraine (EM), Chronic Migraine (CM) and Medication Overuse Headache (MOH) to those of the healthy control group using the Magnetic Resonance Imaging (MRI) technique, also by looking into the correlation between the number of painful days and attacks and the current hippocampal volumes. Methods – A total of 30 patients (10 EM, 10 CM, 10 MOH) from 18 to 45 years of age diagnosed with migraine and also followed up by the neurology outpatient clinic from February to May 2022 and 30 healthy volunteers of similar ages and sexes to the patient group were included in the study. In addition to the routine cranial MRI protocols of all the participants, further cranial images were taken with the addition of the T1W 3D FSPGR sequence adjusted to the hippocampal body in the coronal plane and covering the whole brain. Hippocampal volumes were measured manually. Results – There were 27 females and 3 males in the patient group versus 28 females and 2 males in the control group, and no statistically significant differences in age and sex were found between the groups. The control group had higher average right, left and total hippocampal volumes than the whole patient group, but only the total hippocampal volume was significantly different between the groups. There was a negative correlation between the number of painful days and the measured right hippocampal and total hippocampal volumes; however, the measured values were not statistically significant. Conclusion – It was concluded that the changes in the hippocampal volume in migraine might be associated with the pain characteristics of the disorder.
Minimal invasive transnasal endoscopic removal of intracranial foreign body after airbag deployment
Authors: Kovács Nimród , Vági Zsolt , Tóth-Molnár Edit , Földi János , Bella Zsolt , Barzó Pál
Published: December 2023

Airbag induced injuries such as skull and cervical spine fractures, epidural and subdural hematomas, atlantooccipital dislocations or brainstem lacerations are already documented in published literature, however, no previous case have been published about a penetrating foreign body of the skull base following airbag deployment. Removal of an intracranial foreign body is very dangerous and difficult, or even if it possible and necessary, requires open surgery in most of the cases. In this article we present the minimal invasive, transnasal removal of a coin from the intracranial, frontobasal region using high-resolution endoscopy combined with image-guided navigation. We report the case of a 59-year-old male who was brought to the emergency department after a car accident. He suffered a penetrating injury by a coin that was placed on the car’s airbag at the moment of the accident. Upon the airbag being deployed the foreign body entered the skin through the right lower eyelid, crossing the orbital cavity, ethmoid cells, sphenoid sinus and the anterior part of the planum sphenoidale at an equal distance of 2mm from the two internal carotid arteries, extending into the intracranial space, without injuring the pituitary stalk and the chiasm. We proceeded to remove the coin endoscopically using a transnasal transseptal transsphenoidal approach under general anesthesia. The dura was closed with a multilayer skull base reconstruction technique using two layers of abdominal free fat and nasal septal mucoperiosteal flap. There were no postoperative complications, nor CSF rhinorrhea. The patient was discharged 10 days after the operation. To our knowledge, this is the first published case of a penetrating foreign body of the skull base, extending into the intracranial cavity following airbag deployment. In some dedicated cases, a minimal invasive endoscopic approach should be considered as an alternative to anterior craniotomy if access is possible when foreign bodies from the skull base area need to be removed. This procedure is efficient, safe and minimally invasive.
The use of mathematical editors in the training of mathematics teachers
Authors: Антропова Г.Р. , Матвеев С.Н. , Киселев Б.В.
Published: December 2023

Приводятся способы построения чертежей в евклидовой геометрии и геометрии Лобачевского в процессе конструирования 2-D и 3-D моделей. Сравниваются потенциалы графических редакторов, инструментарий которых предполагает возможность использования метрических измерений в полном изображении. Предлагаются некоторые способы проверки выполненного чертежа при обучении будущих учителей математики решению задач конструктивной геометрии. Делаются выводы о том, что приведенные редакторы эффективны при разработке математических тренажеров по решению задач различных уровней сложности для студентов педагогических вузов.

The methods of constructing drawings in Euclidean geometry and Lobachevsky geometry in the process of constructing 2-D and 3-D models are given. The potentials of graphic editors are compared, the tools of which suggest the possibility of using metric measurements in a full image. Some ways of checking the completed drawing are proposed when teaching future mathematics teachers to solve problems of constructive geometry. Conclusions are drawn that the editors are effective in developing mathematical simulators for solving problems of various levels of complexity for students of pedagogical universities.
An integrative approach to teaching foreign languages: organization of educational and cognitive activities of students in a specialized museum
Authors: Изимариева З.Н. , Мустафина А.Р. , Эделева И.В. , Шпар Т.В.
Published: December 2023

Статья посвящена применению интегративного подхода при обучении иностранным языкам в неязыковом вузе. Проведен анализ интерактивного внеаудиторного занятия по деловому английскому языку с применением интегративного подхода, организованного в специализированном музее лесоводства для студентов направления подготовки «Лесное дело». Изложены основные этапы организации учебно-познавательной деятельности обучающихся. Описаны виды и формы работ, задействованные в анализируемом мероприятии, предложены рекомендации по организации подобного вида занятий в специализированных музеях. Сформулирован вывод о том, что интегративный подход к обучению иностранным языкам позволяет реализовать межпредметные связи и способствует развитию профессиональных навыков будущих специалистов.

The article is devoted to the application of an integrative approach in teaching foreign languages in a non-linguistic university. An analysis was made of an interactive extracurricular business English lesson using an integrative approach, organized in a specialized museum of forestry for students of the “Forestry” fi eld of study. The main stages of the organization of educational and cognitive activity of students are outlined. The types and forms of work involved in the analyzed event are described, recommendations are made for organizing this type of training in specialized museums. The conclusion is formulated that an integrative approach to teaching foreign languages allows the implementation of interdisciplinary connections and contributes to the development of professional skills of future specialists.
Asynchronous method of course design organization
Authors: Степанов А.Г. , Космачев В.М. , Москалева О.И.
Published: December 2023

Целью статьи является описание и доказательство эффективности разработанного авторами метода организации курсового проектирования с использованием системы управления обучением. Рассматривается вариант его организации в рамках самостоятельной работы студента. Обсуждаются вопросы академического мошенничества, приводится их авторская классификация и выделяются методы, связанные с копированием готовых текстов и заказом работ в том числе применительно к chatGPT. Фиксируются недостатки текущей организации курсового проектирования в высшей школе с позиций администрации вуза, методистов, студентов и преподавателей. Обсуждается вариант внедрения модульно-рейтинговой системы оценки результатов выполнения курсовых работ на основе рекомендаций различных авторов и отмечаются ее недостатки. Предлагается авторский асинхронный вариант организации курсового проектирования, основанный на последовательном контроле выполнения этапов курсовой работы с использованием Moodle для возврата исполнителю неудовлетворительного варианта составляющих работы. Приводятся результаты выполнения и оценивания курсовых работ по предлагаемой методике.

The purpose of the article is to describe and prove the eff ectiveness of the method developed by the authors for organizing course design using a learning management system. A variant of its organization within the framework of the student’s independent work is considered. The issues of academic fraud are discussed, their author’s classifi cation is given, and the methods associated with copying ready-made texts and ordering works, including in relation to chatGPT, are highlighted. The shortcomings of the current organization of course design in higher education are fi xed from the standpoint of the university administration, methodologists, students and teachers. The option of introducing a module-rating system for evaluating the results of term papers based on the recommendations of various authors is discussed and its shortcomings are noted. The author’s asynchronous version of the organization of course design is proposed, based on the sequential control of the implementation of the stages of the course work using Moodle to return the unsatisfactory version of the work components to the executor. The results of the implementation and evaluation of term papers according to the proposed methodology are given.
Development of technology of socialization-individualization of preschool children in motor activity: theoretical stage
Authors: Павлова Л.И. , Волошина Л.Н.
Published: December 2023

Приводятся результаты анализа научных подходов к рассмотрению процессов социализации и индивидуализации. Определены основные механизмы их осуществления, специфика в период дошкольного детства. Рассмотрено содержание образовательной деятельности в дошкольных образовательных организациях, нацеленное на поддержку процессов социализации и индивидуализации детей. Выявлены эффективные технологии социализации-индивидуализации дошкольников и потенциал различных видов детской деятельности. Делается вывод о наличии теоретических предпосылок для разработки технологии социализации-индивидуализации детей дошкольного возраста в двигательной деятельности.

The results of the analysis of scientific approaches to the consideration of the processes of socialization and individualization are given. The main mechanisms for their implementation, the specifics in the period of preschool childhood are determined. The content of educational activities in preschool educational organizations, aimed at supporting the processes of socialization and individualization of children, is considered. Effective technologies of socialization-individualization of preschool children and the potential of various types of children’s activities are revealed. The conclusion is made about the presence of theoretical prerequisites for the development of technology of socialization-individualization of preschool children in motor activity.
Theoretical aspects of development of special endurance of cross-country skiers by the method of conjugate influence
Authors: Потапов Ф.С.
Published: December 2023

Рассматриваются теоретические аспекты развития специальной выносливости лыжников-гонщиков с помощью метода сопряженного воздействия. Показана роль основных физических качеств спортсмена. Раскрывается содержание термина «выносливость» как способности спортсмена превозмогать усталость в рамках реализации мышечной деятельности. Показаны детерминанты развития специальной выносливости (предъявляемые к организму требования, необходимые для реализации определенных упражнений; уровень подготовленности внутренних органов и систем организма (например, вегетативная нервная система); волевые качества спортсмена). Делается вывод о том, что предлагаемый метод сопряженного воздействия эффективен для развития анаэробных возможностей лыжника.

Theoretical aspects of the development of special endurance of cross-country skiers with the help of the conjugate impact method are considered. The role of the main physical qualities of an athlete is shown. The content of the term “endurance” is revealed as the ability of an athlete to overcome fatigue in the framework of the implementation of muscle activity. The determinants of the development of special endurance are shown (requirements for the body necessary for the implementation of certain exercises; the level of preparedness of the internal organs and systems of the body (for example, the autonomic nervous system); volitional qualities of an athlete). It is concluded that the proposed method of conjugate exposure is effective for the development of the anaerobic capabilities of the skier.
A new Turkish pharmacokinetics software program for therapeutic drug monitoring of theophylline
Authors: Yıldız Türkyılmaz Gülbeyaz , Ege Mehmet Ali , Alparslan A. Levent , Karasulu Ercüment , Kırılmaz Levent
Published: December 2023

In this study, it was aimed to develop a Turkish software with pharmacokinetic (PK) data for therapeutic drug monitoring and IV dose adjustment of narrow therapeutic index theophylline.
The study involved three groups, each comprising two rabbits The dose required for the target concentration (15µg/mL) was calculated with the developed program according to the weight of the rabbits in the first group. Blood samples taken at certain times were analyzed by validated HPLC method to calculate the elimination rate constant (ke) after IV bolus administration. The r2 values for ke were found to be 0.86 and 0.95. The second dose calculated according to revised PK findings was administered and blood samples were taken. When the analyzed results and theoretical results were compared, the deviation was found to be 5.53% and 8.795%. The findings were taken as the population PK for other applications.
IV multiple dose bolus and IV fast-slow combined infusion were administered to the second group and the third group, respectively. The results obtained from the analysis of blood samples taken at the times determined according to the application were compared with the theoretical results.
As a result, although there is a high difference between theory and practice at low concentrations, there is very little variation at high concentrations. By using this program, it has been achieved to keep theophylline at the desired level without reaching the minimum toxic concentration and without falling below the minimum effective concentration. It is thought that deviations will be reduced with larger samples.
Perbandingan Peran Nahdlatul Ulama (NU) dan Muhammadiyah dalam Politik di Indonesia
Authors: Hawari Alhilal Yusril , Suwaryo Utang , Kartini Dede Sri
Published: December 2023

Tujuan dari penelitian ini adalah untuk mengetahui bagaimana perbandingan dari peran Nahdlatul Ulama (NU) dan Muhammadiyah dalam politik di Indonesia. Penelitian ini diteliti dengan cara penelitian Studi Kepustakaan atau disebut library research yaitu jenis penelitian yang dilakukan untuk melakukan penulisan, melakukan klarifikasi serta mengumpulkan data yang diambil dari banyak sumber baik itu sumber secara tidak tertulis maupun tertulis. dari yang telah diperoleh peneliti yang bersumber dari data tertulis. Teknik mengumpulkan data dalam penelitian ini menggunakan cara dokumentasi atau disebut (Studi Pustaka), melakukan kutipan dan melakukan analisis data dengan Teknik Dokumen ini bertujuan untuk mencari, mengumpulkan dan mengolah data yang dimaksud yang ada didalam yang berasal dari dokumen-dokumen baik berbentuk dokumen tertulis seperti buku, jurnal, maupun sumber tertulis lainnya. Hasil penelitian ini menjelaskan bahwa Nahdhatul Ulama dan Muhammadiyah memiliki perannya masing-masing dalam politik yang ada di Indonesia baik itu sejak awal berdiri hingga sekarang, perbedaan tersebut dapat terlihat jelas dari beberapa perbandingan seperti ideologi, latar belakang, alasan pembentukan, dan orientasi, Temuan di dalam penelitian ini juga menunjukkan bagaimana Nahdhatul Ulama dan Muhammadiyah memberikan dampak nyata bagi masyarakat Indonesia dan perbedaan ideologi yang memberikan dampak yang berbeda dalam politik.
Determination of antioxidant activity, total phenolic and total flavonoid contents in tamarillo (Solanum betaceum) peel's ethanolic extracts
Authors: Silitonga Desni Rinanda , Arianto Anayanti , Silalahi Jansen
Published: December 2023

Background: Free radicals are chemical species a molecule, atom with unpaired electrons and reactive as oxidizing agent which cause oxidize stress in tissue. Antioxidants are substances that can protect cells from free radicals by releasing electrons to neutralize free radicals. Tamarillo peel contains phenolic and flavonoid compounds which have antioxidant activity.  The aim of this study was to determine the antioxidant activity, total phenolic and flavonoid content of the ethanol extract of tamarillo peel.
Methods:  In this research, the maceration method was used to extract phenolic and flavonoid components from tamarillo peel with ethanol 70% solvent. Total phenolic and flavonoid content was determined with UV-vis spectrophotometer. Total phenolic content determined using the Folin-Ciocalteu reagent and expressed in GAE (Garlic acid equivalent) and the total flavonoid content used the AlCl-3 reagent and expressed in QE (Quersetin equivalent). Then, tamarillo peel ethanol extract was tested the antioxidant activity using the DPPH method.
Result: The results showed that the total polyphenol content was 66.6242 mg GAE/g extract or 6.66% w/v extract, total flavonoid content was 0.74246 % w/v or 7.4246 mg QE/g extract. Antioxidant activity in IC50 value was 47.9460 ppm.
Conclusions: From the results of the research conducted, it can be seen that the ethanol extract of tamarillo can provide an antioxidant effect in the very strong category.
Anterior mediastinal schwannoma: A rare case report
Authors: Mohapatro Meenakshi , Tripathy Milan , Sahoo Swati Smita , Mishra Deepika , Balbantray Alakananda , Mohanty Shushruta
Published: December 2023

Mediastinal schwannomas are rare tumors that develop from peripheral nerve sheath in the mediastinum. Most commonly they are located in posterior mediastinum and are very unusual in anterior mediastinum like the present study of a 51 year old male. He presented with breathlessness, dyspnea and cough for 3 months. Radiological imaging, CT scan reports revealed a cystic SOL in anterior superior mediastinum. The patient underwent thoracotomy and on histopathological examination revealed features of schwannoma which was further confirmed by immunohistochemical study with S-100 protein. Prognosis is good for such tumours and no recurrence is yet reported.
Acute intermittent porphyria (AIP) in 27 year old female patient- Case report
Authors: Hawaldar Ranjana , Khan Shana Nikhat
Published: December 2023

Acute Intermittent Porphyria (AIP) is the most common acute and probably the most common inherited porphyria. AIP is caused due to deficiency of hydroxymethylbilane synthase (HMBS). AIP is characterized by a classical triad of abdominal pain, central nervous system abnormalities and peripheral neuropathy. We report a case of 27 year old female patient with recurrent episodes of acute abdominal pain. Patient underwent all laboratory & imaging investigations at our centre.
Uterine leiomyoma with bizarre nuclei – A series of four cases
Authors: Mishra Shilpa , Patkar Rakesh Rajiv , Neelakantan Amrita
Published: December 2023

Uterine leiomyoma is the most common benign mesenchymal tumor of the uterus occurring in females of reproductive age group and are derived from smooth muscle. Degenerative changes are usual in leiomyoma. There is a wide spectrum of morphological patterns in leiomyomas, among them 90% of leiomyomas are the conventional type or usual type. Leiomyoma with bizarre nuclei is an unusual variant of uterine leiomyoma with presence of marked nuclear atypia and pleomorphism. However, there is low mitotic activity (< 5 mitoses/10 high power fields), absence of tumor cell necrosis and intermixed normal spindled smooth muscle cells. The present study describes histopathological analysis of 4 cases of leiomyoma with bizarre nuclei. All these cases underwent abdominal hysterectomy for leiomyomas in the uterus. The age range was 47 to 52 years. On gross examination the cases had well-defined masses with grey white, whorled areas and microscopic impression was leiomyoma with bizarre nuclei. These cases had low mitotic activity ranging from 1 to 3/ 10 high power fields and absence of tumor necrosis. Ki 67 index was 0.5 -1.0%. Leiomyoma with bizarre nuclei can create a diagnostic dilemma due to marked nuclear atypia, multinucleated tumor cells and karyorrhectic cells resembling mitotic figures. Hence it is important to rule out more aggressive and malignant mesenchymal tumors.
La experiencia económica del exilio centroamericano en México (1829-1844)
Authors: Gonzalez-Galeotti Francisco Rodolfo
Published: December 2023

Entre 1829 y 1855 un gran número de centroamericanos exiliados por la guerra federal se avecindaron en México. El artículo parte de la pregunta ¿cómo se sostuvieron económicamente fuera de su patria?, para responder, se han estudiado memorias, correspondencia, protocolos notariales, juicios e historiografía económica con la finalidad de seguir el rastro de algunos exilados y su inserción económica en México. Se estudiaron las experiencias de los exiliados en Chiapas, San Luis Potosí, Oaxaca y el occidente mexicano. Además, se reconstruyeron las trayectorias económicas de los centroamericanos y las redes sociales en que se apoyaron para prosperar. El análisis encontró a un grupo económicamente dinámico que pudo sortear las vicisitudes políticas de Centroamérica y México, gracias a aliados en altas esferas de gobierno, diplomacia y negocios regionales. Asimismo, gracias a las afinidades con las elites mexicanas y las experiencias económicas previas al exilio, este conjunto de exiliados pudo arraigar en México.
Estudio talento digital en el Perú 2023: la demanda insatisfecha de talento digital en el Perú
Authors: Novella Rafael , Rosas-Shady David
Published: December 2023

El documento presenta los principales resultados de una encuesta innovadora a empresas que ha desarrollado el Banco Interamericano de Desarrollo para apoyar a los países de la región con la mejora de su talento digital. La encuesta analiza el nivel de transformación digital de un grupo de empresas peruanas; pone en evidencia la existencia de una importante brecha entre la demanda de habilidades digitales de las empresas y la oferta de habilidades digitales de la fuerza laboral; cuantifica la demanda por perfiles TI; e identifica las principales estrategias y dificultades que enfrentan las empresas para atender sus necesidades de talento digital. El documento también presenta recomendaciones sobre las políticas que se podrían implementar para reducir estas brechas.
América Latina y el Caribe en PISA 2022: ¿cuántos tienen bajo desempeño?
Authors: Arias Ortiz Elena , Bos María Soledad , Giambruno Cecilia , Zoido Pablo
Published: December 2023

Tres de cada cuatro estudiantes de la región tienen bajo desempeño en Matemática y la mitad no tiene habilidades básicas de Lectura. Entre 2018 y 2022 este porcentaje aumentó en casi todos los países de la región.