bluuebunny/crossref_metadata_2025 huggingface dataset:
A cost-effectiveness and safety analysis of dual antiplatelet therapy comparing aspirin–clopidogrel to aspirin–ticagrelor in patients with acute coronary syndrome
Authors: Nafrialdi Nafrialdi , Handini Novita M. , Instiaty Instiaty , Wijaya Ika P.
Published: December 2018

Background: Dual antiplatelet therapy (DAPT) using either an aspirin–clopidogrel (A–C) combination or aspirin–ticagrelor (A–T) combination has become the standard therapy for acute coronary syndrome (ACS). Ticagrelor shows better pharmacokinetic profiles but is more expensive. This study aimed to compare cost-effectiveness and safety profiles of A–C versus A–T in patients with ACS.Methods: This was a retrospective cohort study of ACS patient at the Cipto Mangunkusumo Hospital between 2014 and 2016. ACS patients treated for the first time with A–T or A–C were included. Occurrence of major adverse cardiovascular events (MACE) within 3, 6, 9, and 12 months were used as effectiveness outcomes, while safety outcomes were measured based on the incidence of adverse drug reactions (major and minor bleeding, dyspnea, and hyperuricemia). Cost-effectiveness analysis was presented as incremental cost-effectiveness ratio (ICER).Results: Data records obtained from 123 ACS patients treated with A–C and 57 ACS patients treated with A–T were evaluated. Within the first three months, the MACE rate was 15.8% in the A–T group and 31.7% in the A–C group (RR: 0.498, 95% CI: 0.259–0.957, p=0.039). There was no statistically significant difference observed in the number of MACE between groups after 6, 9, and 12 months. The A–T group had a higher incidence of major bleeding (melena) than the A–C group (5.3% vs 1.62%, p=0.681), especially in geriatric patients. Minor bleeding was observed in three patients of the A–C group, but in none of the patients in the A–T group. The cost of ICER was IDR 279,438, indicating the additional cost needed for avoiding MACE within 3 months, if A–T was used.Conclusion: The aspirin–ticagrelor combination is a clinically superior and cost-effective option for MACE prevention among ACS patients, especially during the first three months of DAPT, with a slight but not significantly higher major bleeding risk when compared to the aspirin–clopidogrel combination.
Corrigendum: Perception of the Zika virus infection and its influence on Zika prevention practices by pregnant women at the Region 5 Health Promotion Center in Thailand
Authors: Siramaneerat Issara
Published: December 2018

[no abstract available]
Hizkuntz erlatibitatea espazio-markagailuen argitan: azken hogei urteetako ikerketen zenbait aitzinamendu
Authors: Aurnague Mixel
Published: December 2018

1940ko hamarkadaren hastapenean Whorfek azaldu, eta 1956an egilearen lan hautatuak argitaratu ostean (hil ondoko argitalpen gisa), «hizkuntz erlatibitate printzipioak» hainbat zorte ezagutu ditu. Hizkuntz erlatibitateari loturiko ideien eta haien aurrekarien ikusmira zabala eskainiz hasten da artikulu hau, ondotik kontrakoa den unibertsalismoaren jarrera aurkeztua delarik: azken hau hedatuena izan da ideien historian zehar eta hala dirau azken berrogeita hamar-hirurogei urteetan, zientzia kognitiboen sortze eta gailentzearen ondorioz. 1990eko hamarkadaren erditsuan, erlatibitatearen hipotesia nola argitua eta berrazaldua izan zen —hizkuntz erlatibitate berriztatuari bidea eginez— aipatzen da jarraian, baita esparru birmoldatu horretan obratu den ikerketa mordoa ere, espazio-semantikaren alorrean bereziki. Hizkuntz erlatibitatea eta unibertsalismoa bateratzen saiatzen den ikuspegi alternatiboa zehazten da azkenik, mintzaira eta gogamenaren arteko uztartze hobeagoa helburu duena.
Ironiaren teoria minimala
Authors: Garmendia Joana
Published: December 2018

Ironia pragmatikaren ikuspuntutik azaltzen duten teorien artean, Griceren hurbilpena (Grice 1967a/89, 1967b/89) eta Oihartzunaren teoria (Sperber & Wilson 1981; Wilson & Sperber 2012) dirateke garrantzitsuenak. Bi teoria horiek nahiko baldintza zorrotzak ezartzen dizkiote esaldi ironikoari: Griceren arabera, hiztun ironikoak kualitatearen lehen azpi-maxima urratzen du eta, horrela, esaldiaren esanahi literalaren aurkakoa inplikatzen du; Sperber eta Wilsonen arabera, hiztun ironikoak oihartzun egiten dio hiztunak bera (une horretan) ez den norbaiti egozten dion pentsamendu/esaldi bati, eta bere burua disoziatzen du pentsamendu edo esaldi horretatik. Hemen zera erakusten dut, bi hurbilpen horiek arazoak dituztela zenbait ironia-adibide azaltzeko oihartzunaz eta kontraesanaz dituzten nozioetan oinarrituta. Jarraian, bestelako hurbilpen baten alde egiten dut. Honako hau da nire proposamena: oihartzunaren eta kontraesanaren nozio zorrotzak ironia-adibide guztiei egokitzen saiatzeko ordez, ironia kasu guztiak lotzen dituena zerbait oinarrizkoagoa dela defendatzen dut –baldintza sorta minimal bat. Amaitzeko, oihartzuna eta kontraesana ironiaren arrastotzat hartu beharko genituela defendatzen dut.
Kardinalen potentziez eta Shelahren PCF aieruaz
Authors: Martínez Juan Carlos
Published: December 2018

PCF teoriarekin erlazionatuta argitzeke dauden arazo batzuk deskribatzen ditugu.PCF teoriarekin erlazionatuta argitzeke dauden arazo batzuk deskribatzen ditugu.
Ohar bat bi patologikotasun-iturri dituzten hizkuntzei buruz
Authors: Martínez-Fernández José , Martí Genoeva
Published: December 2018

Patologia semantikoen bi iturri desberdin dituzten hizkuntzetan jarriko dugu arreta: proposizio bat adierazten ez duten perpausetan eta, proposizio bat adierazten duten arren, ez egiazko eta ez faltsu diren perpausetan. Hizkuntza horiei hiru baliodun semantika bat ematen zaienean, perpaus patologiko guztiak bildu egiten dira eta hirugarren egibalioa esleitzen zaie. Lan honetan, hasteko, deskripzio definitudun hizkuntzen kasua aurkeztuko dugu; horietan, marraz daiteke bi perpaus patologiko mota horien arteko bereizketa. Gero, lau baliodun semantika bat arakatuko dugu, perpaus patologikoen bi motak bereiz ditzakeena.
Micobiota de la ZEC Gándaras de Budiño (Pontevedra, N.O. Península Ibérica)
Authors: Requejo Oscar
Published: December 2018

La Zona de Especial Conservación (ZEC) Gándaras de Budiño está situada en el suroeste de la provincia de Pontevedra (Galicia, Península Ibérica). A pesar de las agresiones sufridas a lo largo de la historia, aún se conservan zonas muy representativas de esta con fauna y flora propia de estos lugares y poco frecuente en el resto del N.O. peninsular. Ocupa una extensión de aproximadamente 800 ha, en las que destacan un amplio complejo de humedales, conformados por turberas, brañas, bosques aluviales y lagunas, así como brezales atlánticos, bosques de ribera y amplias extensiones más secas, constituidas básicamente por bosques mixtos de robles y pinos. En este espacio se realiza un estudio micológico con recolecciones periódicas durante 4 años, de las cuales resulta un catálogo con 359 taxa, con una aportación al catálogo gallego de 62 especies. Entre ellas destaca Chaetotyphula actinipes, que se menciona por primera vez para Europa, además de Arnium olerum, Byssosphaeria schiedermayeriana, Conocybe brachypodii, Cordyceps polyarthra, Hemimycena angustispora, Inocybe salicis, Laccaria impolita, Mollisia olivascens, Mycena atrovinosa, Mycena mucor, Oligoporus alni, Russula sphagnophila y Trichoderma piluliferum, no mencionados anteriormente para la Península Ibérica. Desde el punto de vista de la estrategia trófica destacan las especies entomapatógenas: Beauveria bassiana, Cordyceps polyarthra, Gibellula pulchra, Isaria farinosa y Torrubiella arachnophila. De las restantes 125 son micorrícicas, 211 son saprotróficas y 38 necrotróficas, en ambos casos, mayoritariamente lignícolas, justificado porque las ¾ partes del material ha sido recolectado en formaciones arbóreas de Alnus glutinosa y Salix atrocinerea. Además, se analiza la autoecología de las especies, los patrones de fructificación y su aportación corológica, tanto ibérica como mundial.
¿Un vestigio feudal dentro del régimen liberal? En torno a los censos en la legislación desamortizadora
Authors: Martínez-Vilches David
Published: December 2018

Este artículo examina el cambio jurídico y social que supuso la desamortización de censos durante la revolución liberal en España. La legislación desamortizadora transformó la propia concepción de los censos como formas de explotación de la tierra y el trabajo al admitir su redención y, por tanto, el acceso de los censatarios a la plena propiedad de la tierra anteriormente acensuada. Esto no solo repercutía en el fenómeno desamortizador general, sino que también permitió acomodar estas figuras jurídicas de origen antiguo al nuevo régimen liberal, pues diferenciaba entre los censos de los bienes nacionales, redimibles a través de la normativa desamortizadora, y los censos entre particulares, que permanecían como derechos de propiedad privada, a pesar de que no fuesen de “propiedad perfecta”. También se analizan proyectos de reforma como los de los ilustrados o el de Flórez Estrada, que nos revelan una mayor complejidad respecto a las ideas liberales sobre la propiedad de la tierra, más allá de las disposiciones finalmente llevadas a cabo.
Los jefes del primer carlismo
Authors: Caridad Salvador Antonio
Published: December 2018

En este artículo he intentado averiguar qué tipo de personas fueron los jefes carlistas que participaron en la primera guerra. Para ello he seleccionado a los 100 más destacados y he elaborado una serie de estadísticas con sus datos biográficos. La información la he extraído de la obra de Pirala, de otros trabajos sobre la Primera Guerra Carlista y de varias obras biográficas sobre jefes carlistas. Con esta investigación he podido saber que la mayoría de los jefes carlistas procedían de Cataluña, el País Vasco y Navarra, que eran en su mayoría militares apartados del servicio o jefes de voluntarios realistas y que tuvieron una trayectoria vital bastante variada, habiendo entre ellos idealistas, pragmáticos y oportunistas.
30 años de la revista Historia Contemporánea
Authors: Esteban de Vega Mariano
Published: December 2018

La revista Historia Contemporánea fue creada en 1988, dentro del departamento de Historia Contemporánea de la Universidad del País Vasco, por iniciativa de Manuel Tuñón de Lara, uno de los principales referentes de la historiografía española al final del franquismo. Desde entonces, ha sido una de las revistas españolas de historia más prestigiosas y, en los últimos años, también una de las que han alcanzado un mayor impacto editorial.Este artículo realiza una historia de los treinta años de esta publicación e identifica sus fases principales. Su evolución se inserta además en los cambios experimentados por la historiografía española de su tiempo, de la que ha sido uno de sus principales referentes. Tanto sus contenidos como su configuración actual resultan significativos de la progresiva asimilación por el medio académico español de las pautas seguidas a escala internacional por las publicaciones científicas.Palabras Clave:  Historia de la historiografía; historiografía española; revistas de historia; Manuel Tuñón de Lara
El principio de voluntariedad como presupuesto sustantivo del trabajo a tiempo parcial
Authors: Callau Dalmau Pilar
Published: December 2018

A pesar de que la figura del contrato a tiempo parcial exige además de una prestación de servicios regular realizada durante una jornada inferior a la ordinaria comparable, que la misma se haya acordado de una forma voluntaria, organismos internacionales advierten sobre el incremento y el excesivo peso que está cobrando el trabajo a tiempo parcial involuntario. Esta naturaleza voluntaria recogida en diferentes ordenamientos supranacionales como una de las mayores preocupaciones de las leyes sobre el trabajo a tiempo parcial, por ser el factor que distingue este tipo de trabajo del subempleo visible, no es reconocida en el ordenamiento español como uno de los principios básicos en su regulación, hasta la modificación legislativa llevada a cabo por una transposición de las normas comunitarias, para la mejora del mercado de trabajo en relación con el trabajo a tiempo parcial y el fomento de su estabilidad. En este artículo, tras analizar la delimitación y los referentes normativos del principio de voluntariedad como elemento configurador del trabajo a tiempo parcial, se concreta su concurrencia en la extensión del contrato, desde su inicio y desarrollo hasta su finalización, y cómo su aplicación es imprescindible, para evitar la desnaturalización de la relación laboral adquirida.
La Renta Básica incondicional ante las limitaciones de las rentas mínimas
Authors: Bollain Urbieta Julen , Raventós Pañella Daniel
Published: December 2018

En el presente artículo realizamos, a partir de los parcelados es-tudios existentes, una revisi􀀌n integral y detallada acerca de la efi-cacia y las limitaciones de los programas de rentas mínimas. Asi-mismo, procedemos a analizar cuál es el comportamiento de la renta básica incondicional ante las deficiencias estructurales detectadas en los programas de rentas mínimas.
Il tempio dei divi Traiano e Plotina, l’arco partico e l’ingresso settentrionale al foro di Traiano: un riesame critico delle scoperte archeologiche
Authors: La Rocca Eugenio
Published: December 2018

Riassunto: Del templum divi Traiani abbiamo sicure attestazioni dalle fonti le quali, tuttavia, non chiariscono quale fosse la morfologia dell’edificio né quale fosse la sua effettiva ubicazione, che sappiamo, comunque, connessa con la colonna di Traiano. I recenti scavi eseguiti nelle fondazioni del palazzo Valentini non hanno risolto il problema. La riproposizione di un edificio templare di ordine gigantesco, con 8 × 10 (o 9) colonne di granito egiziano di 50 piedi di altezza, continua a basarsi sulla ricostruzione ipotetica dell’area a settentrione del foro di Traiano codificata da Guglielmo Gatti (sulla base di appunti del nonno Giuseppe) e da Italo Gismondi. In realtà, le indagini finora compiute non lo consentono. Inoltre, le soluzioni finora proposte non tengono conto dell’arco partico di Traiano, la cui collocazione all’ingresso meridionale del foro di Traiano, come suggerito da Rodolfo Lanciani e da Italo Gismondi, non può più essere sostenuta. È verosimile che l’arco, i cui lavori, avviati nel maggio del 116 d.C. erano ancora in corso al momento della morte di Traiano, il 7 agosto del 117 d.C., fosse invece all’ingresso principale del foro, il settentrionale, in un’area interessata da interventi edilizi di Adriano, di cui ci sfuggono, purtroppo, l’entità e le motivazioni. La presenza obbligatoria dell’arco partico nella zona parzialmente occupata dal templum divi Traiani, almeno secondo le più recenti proposte di ricostruzione, costringe a rivedere su basi differenti l’assetto adrianeo dell’area del foro di Traiano a nord della colonna coclide.Parole chiave: Traiano, topografia romana, architettura romana.
Traiano e la costruzione della sua immagine nel Foro
Authors: Ungaro Lucrezia
Published: December 2018

Riassunto: La scoperta di un nuovo ritratto colossale di Traiano avvenuta durante la preparazione della mostra “Traiano. Costruire l’Impero, creare l’Europa”, produce una rinnovata lettura del complesso programma figurativo voluto dall’imperatore nel suo Foro. Nel quadro della sua azione politica, militare e sociale, il Foro è infatti la massima rappresentazione della sua virtus imperatoria e della maiestas populi romani. In particolare, vengono riconsiderati i ritratti del Traianus Pater e della cosiddetta Agrippina/Marcia, alla luce di una possibile galleria dedicata alla famiglia genetica di Traiano e ai suoi modelli, come Giulio Cesare. Pari attenzione si dedica alla distribuzione delle sculture e dei rilievi noti negli spazi forensi, al loro rapporto gerarchico nello spazio sovradimensionato della piazza. Da ultimo, viene ripresa la proposta di riconoscere nell’aula trisegmentata la porticus porphiretica, riesaminando in via preliminare le sculture note in porfido attribuibili al Foro, e alcuni frammenti conservati nei depositi del Museo dei Fori Imperiali che acquisiscono così nuovo interesse.Parole chiave: nuovo ritratto colossale di Traiano, Agrippina/Marcia, Traianus Pater, programma figurativo del Foro, virtus imperatoria, la famiglia imperiale.
Presentación
Authors: González J. , Ruiz-Gutiérrez A.
Published: December 2018

Presentación al Dossier
Semiótica de la intertemporalidad en medios videolúdicos. Propuesta de una matriz de análisis
Authors: Parra Cristian Felipe
Published: December 2018

La mayoría de los videojuegos ludo-narrativos suponen relaciones temporales entre elementos narrativos de distinta naturaleza, principalmente elementos hipertextuales y elementos cibertextuales (narrativas autogeneradas por un simulador de realidad virtual). Estas relaciones tienen un ritmo que marca el desarrollo del discurso videolúdico en el universo narrativo. A partir de la identificación de los elementos constituyentes de ese ritmo intertemporal, este trabajo propone una tipología de relaciones que puede servir como matriz para el análisis del relato videolúdico en la medida que permite describir con mayor precisión la configuración temporal de este tipo particular de narrativas.PALABRAS CLAVE: Narración, hipertextualidad, games studies, videojuegos,semiótica, narrativa.
El racismo discursivo en la prensa escrita: una mirada teórica desde el Análisis Crítico del Discurso y la Sociología de los medios.
Authors: Sáez Gallardo Julio Renato
Published: December 2018

Esta aproximación teórica pretende como objetivo central comprender cómo las rutinas profesionales de los periodistas y de los medios de comunicación condicionan la contrucción noticiosa acerca de las minorías étnicas. Para ello, emplearemos el Análisis Crítico del Discurso y la Sociología de los medios y sus correspondientes categorías analíticas como constructos epistemológicos y metodológicos y las vincularemos a investigaciones teórico-empíricas para validar la hipótesis de este trabajo: la praxis racista de la cultura periodística  deviene de  condicionamientos propios del quehacer de las organizaciones mediáticas, lo que produce un discurso discriminador referente a las minorias étnicas ( migrantes y pueblos originarios).
Pautas de redacción y análisis de contenido en noticias sobre suicidio en la prensa española e internacional: efecto Werther&Papageno y seguimiento de las recomendaciones de la OMS
Authors: Lois-Barcia Melani , Rodríguez-Arias Icía , Túñez Miguel
Published: December 2018

En España fallecen por suicidio el triple de personas que en accidente de tráfico, pero la muerte intencional sigue siendo un asunto que en las redacciones informativas se silencia por considerar que su visibilidad fomenta el aumento de conductas imitativas. La Organización Mundial de la Salud promueve desde 2000 una guideline para el abordaje informativo del suicidio en la que se proponen comportamientos diferentes: informar con  responsabilidad y de modo que se colabore en dinámicas de prevención. Esta investigación revisa libros de estilo o códigos de conducta de FAPE, de los nueve colegios profesionales de España y de 23 organizaciones profesionales internacionales y analiza las noticias online durante seis meses en una muestra intencional de 11 periódicos de referencia (El País, El Mundo, La Vanguardia, La Voz de Galicia y El Periódico, The Guardian, Le Monde, The New York Times, The Washington Post, Corrieri della Sera y Público) para identificar si existen pautas que orienten el abordaje informativo e intentar determinar si la política informativa apuesta por fomentar el efecto Werther (silencio) o el efecto Papageno (prevención).PALABRAS CLAVE: Medios de comunicación, responsabilidad social,prensa, suicidio.
¿Quiénes hablan en las noticias? Desequilibrio de género en las fuentes informativas de la prensa de proximidad
Authors: Prieto Sánchez Cristina
Published: December 2018

El objetivo de este artículo es determinar si mujeres y hombres participan de manera equilibrada en los contenidos que los medios ofrecen a la audiencia. El análisis de los datos constata que ni las voces recogidas en las noticias ni sus posiciones dentro de las mismas alcanzan la paridad. Las mujeres ocupan lugares poco relevantes y desaparecen de los informativos locales en el tránsito de las convocatorias a las noticias elaboradas. Este artículo presenta los resultados de un estudio de caso realizado sobre los medios de Granada para el que se han evaluado 1.586 informaciones y 184 convocatorias de agenda.palabras clave: Medios de comunicación, comunicación local, género, fuentes informativas.
Revistas iberoamericanas sobre Comunicación
Authors: Goikoetxea Bilbao Udane
Published: December 2018

Las revistas sobre comunicación que publican en castellano, proponen diversos temas no siempre novedosos. Analizan tanto la comunicación como las nuevas tecnologías aplicadas a diversas situaciones y la cultura de masas. Algunas de las revistas no han publicado ningún número durante 2018.
Thermal efficiency and emission characteristics of a diesel-hydrogen dual fuel CI engine at various loads condition
Authors: Putrasari Yanuandri , Praptijanto Achmad , Nur Arifin , Santoso Widodo Budi , Pratama Mulia , Dimyani Ahmad , Suherman Suherman , Wahono Bambang , Wardana Muhammad Khristamto Aditya , Lim Ocktaeck
Published: December 2018

Efforts to find alternative fuels and reduce emissions of CI engines have been conducted, one of which is the use of diesel hydrogen dual fuel. One of the goals of using hydrogen in dual-fuel combustion systems is to reduce particulate emissions and increase engine power. This study investigates the thermal efficiency and emission characteristics of a diesel-hydrogen dual fuel CI engine at various loads condition. The hydrogen was used as a secondary fuel in a single cylinder 667 cm3 diesel engine. The hydrogen was supplied to intake manifold by fumigation method, and diesel was injected directly into the combustion chamber. The results show that the performance test yielding an increase around 10% in the value of thermal efficiency of diesel engines with the addition of hydrogen either at 2000 or 2500 rpm. Meanwhile, emission analyses show that the addition of hydrogen at 2000 and 2500 rpm lead to the decrease of NOx value up to 43%. Furthermore, the smokeless emissions around 0% per kWh were occurred by hydrogen addition at 2000 and 2500 rpm of engine speeds with load operation under 20 Nm.
Enhancement of motionability based on segregation of states for holonomic soccer robot
Authors: Dewantoro Gunawan , Suprayudi Anton , Santoso Daniel
Published: December 2018

One of the critical issues when navigating wheeled robot is the ability to move effectively. Omnidirectional robots might overcome these nonholonomic constraints. However, the motion planning and travel speed of the movement has been in continuous research. This study proposed segregation of states to improve the holonomic motion system with omnidirectional wheels, which is specially designed for soccer robots. The system used five separate defined states in order to move toward all directions by means of speed variations of each wheel, yielding both linear and curved trajectories. The controller received some parameter values from the main controller to generate robot motion according to the game algorithm. The results show that the robot is able to move in an omnidirectional way with the maximum linear speed of 3.2 m/s. The average error of movement direction is 4.3°, and the average error of facing direction is 4.8°. The shortest average time for a robot to make a rotational motion is 2.84 seconds without any displacement from the pivot point. Also, the robot can dribble the ball forward and backward successfully. In addition, the robot can change its facing direction while carrying the ball with a ball shift of less than 15 cm for 5 seconds. The results shows that state segregations improve the robots capability to conduct many variations of motions, while the ball-handling system is helpful to prevent the ball gets disengaged from the robot grip so the robot can dribble accordingly.
Implementation of a LiFePO4 battery charger for cell balancing application
Authors: Amin Amin , Ismail Kristian , Hapid Abdul
Published: December 2018

Cell imbalance has always happened in the series-connected battery. Series-connected battery needs to be balanced to maintain capacity and maximize the batteries lifespan. Cell balancing helps to dispart energy equally among battery cells. For active cell balancing, the use of a DC-DC converter module for cell balancing is quite common to achieve high efficiency, reliability, and high power density converter. This paper describes the implementation of a LiFePO4 battery charger based on the DC-DC converter module used for cell balancing application. A constant current-constant voltage (CC-CV) controller for the charger, which is a general charging method applied to the LiFePO4 battery, is presented for preventing overcharging when considering the nonlinear property of a LiFePO4 battery. The prototype is made up with an input voltage of 43V to 110V and the maximum output voltage of 3.75V, allowing to charge a LiFePO4 cell battery and balancing the battery pack with many cells from 15 to 30 cells. The goal is to have a LiFePO4 battery charger with an approximate power of 40W and the maximum output current of 10A. Experimental results on a 160AH LiFePO4 battery for some state of charge (SoC) shows that the maximum battery voltage has been limited at 3.77 volt and maximum charging current could reach up to 10.64 A. The results show that the charger can maintain battery voltage at the maximum reference voltage and avoid the LiFePO4 battery from overcharging.
Designing optimal speed control with observer using integrated battery-electric vehicle (IBEV) model for energy efficiency
Authors: Ristiana Rina , Rohman Arief Syaichu , Rijanto Estiko , Purwadi Agus , Hidayat Egi , Machbub Carmadi
Published: December 2018

This paper develops an optimal speed control using a linear quadratic integral (LQI) control standard with/without an observer in the system based on an integrated battery-electric vehicle (IBEV) model. The IBEV model includes the dynamics of the electric motor, longitudinal vehicle, inverter, and battery. The IBEV model has one state variable of indirectly measured and unobservable, but the system is detectable. The objectives of this study were: (a) to create a speed control that gets the exact solution for a system with one indirect measurement and unobservable state variable; and (b) to create a speed control that has the potential to make a more efficient energy system. A full state feedback LQI controller without an observer is used as a benchmark. Two output feedback LQI controllers are designed; including one controller uses an order-4 observer and the other uses an order-5 observer. The order-4 observer does not include the battery state of charge as an observer state whereas the order-5 observer is designed by making all the state variable as the observer state and using the battery state of charge as an additional system output. An electric passenger minibus for public transport with 1500 kg weight was used as the vehicle model. Simulations were performed when the vehicle moves in a flat surface with the increased speed from stationary to 60 km/h and moves according to standard NEDC driving profile. The simulation results showed that both the output feedback LQI controllers provided similar speed performance as compared to the full state feedback LQI controller. However, the output feedback LQI controller with the order-5 observer consumed less energy than with the order-4 observer, which is about 10% for NEDC driving profile and 12% for a flat surface. It can be concluded that the LQI controller with order-5 observer gives better energy efficiency than the LQI controller with order-4 observer
ISOLASI SENYAWA ANTIOKSIDAN DALAM EKSTRAK HEKSANA KULIT BATANG MANGGIS HUTAN (Garcinia bancana Miq.)
Authors: Hartati Sri , Masrukhan Masrukhan , Cahyana Herry
Published: December 2018

Antioksidan adalah suatu senyawa yang dapat menangkap radikal bebas. Salah satu sumber anti oksidan alami adalah dari tumbuh-tumbuhan. Dalam usaha pencarian antioksidan baru, telah dilakukan identifikasi senyawa antioksidan dari ekstrak n-heksana kulit batang Garcinia bancana Miq dengan metode 1,1-difenil-2-pikrilhidrazil (DPPH). Metode isolasi dilakukan dengan cara  kombinasi kromatografi (Kromatografi kolom vacum, kromatografi kolom gravitasi, kromatografi lapis tipis  sentrifugal dan kromatografi lempeng tipis)  Penentuan struktur molekul berdasarkan analisis data spektroskopi UV-VIS, IR, LC-MS, NMR proton dan karbon. Dari  hasil isolasi didapatkan suatu senyawa isoprenil bezofenon dengan bobot molekul 466,22 dan  rumus molekul C28H34O6 dengan nama IUPAC 3-(3,4-dihidroksibenzoil)-4-hidroksi-8-8-dimetil-1,7-bis(3-metilbut-2enil) bisiklo (3.3.1) non-3-ene-2,9-dione atau disebut bacanone yang diduga senyawa baru. Dari proses isolasi juga ditemukan senyawa atsiri b- caryophyllene, α-humulene dan b-cadinene serta stigmasterol. Hasil uji aktivitas antioksidan ekstrak n-heksana dan hasil isolat murni menunjukkan IC50 berturut-turut 17,78 ppm dan 12,79 ppm dimana pembanding kuersetin adalah 9,90 ppm.Kata kunci:  Garcinia bancana, antioksidan, DPPH, 3-(3,4-dihidroksibenzoil)-4-hidroksi-8-8-dimetil-1,7-bis(3-metilbut-2enil)bisiklo(3.3.1)no-3-ene-2,9-dione, bacanone. Antioxidants are compounds that can capture free radicals. One source of natural antioxidant is from plants. On searching  for new antioxidant, identification of antioxidant compound of the n-hexane extract of the stem bark of Garciniabancana Miq was done by  1.1-diphenyl-2-pikrilhidrazil (DPPH) method. Isolation active compound were done by combination of chromatographic methods (Flash column chromatography, gravitation column chromatography, cetrifugal thin layer chromatography and thin layer chromatography) .Determination of molecular structure by analysis spectroscopic data of UV-VIS, IR, LC-MS, NMR proton and carbon.Isolation results were      isophrenyl bezophenon with molecular weight 466.22 and the molecular formula is C28H34O6 IUPAC name 3 - (3,4-dihydroxybenzoil)-4-hydroxy-8-8-dimethyl-1,7-bis (3-methylbut-2enyl) bicyclo (3.3.1) non-3-ene-2,9-dione or named bacanone wich is suspected as a new compound. From the isolation were also found of known volatile compounds b - caryophyllene, α-humulene and b-cadinene and stigmasterol. The test results of antioxidant activity of  n-hexane extract and pure compound  showed IC50 respectively 17.78 ppm and 12.79 ppm which comparison with  quercetin is 9.90 ppm. Key words :  Garcinia bancana Miq., antioxidant, DPPH, 3-(3,4-dihydroxybenzoil)-4-hidroxy-8-8-dimethyl-1,7-bis (3-methylbut-2enil)bisiklo(3.3.1)no-3-ene-2,9-dione, bacanone.
SINTESIS, UJI AKTIVITAS SITOTOKSIK IN VITRO DAN MOLECULAR DOCKING SENYAWA 1-(4-KLOROBENZOIL)-1,3-DIMETILUREA
Authors: Pangaribowo Dian Agung , Siswandono Siswandono , Purwanto Bambang Tri
Published: December 2018

Senyawa 1-(4-klorobenzoil)-1,3-dimetilurea telah dirancang, disintesis, diidentifikasi struktur, dan diuji aktivitas sitotoksik secara in vitro. Simulasi docking dilakukan dengan memposisikan senyawa ke dalam sisi aktif reseptor Checkpoint kinase 1 (Chk1) untuk menentukan model pengikatan ligan reseptor. Sintesis 1-(4-klorobenzoil)-1,3-dimetilurea dilakukan lewat reaksi asilasi antara 1,3-dimetilurea dan 4-klorobenzoil klorida. Kemurnian produk hasil sintesis ditentukan dengan metode Kromatografi Lapis Tipis (KLT).Identifikasi struktur dilakukan dengan spektrofotometer UV, FT-IR dan spektrometer NMR. Hasil uji antiproliferatif menunjukkan bahwa senyawa 1-(4-klorobenzoil)-1,3-dimetilurea memiliki aktivitas sitotoksik terhadap sel HeLa yang lebih baik dibandingkan dengan kontrol positif yaitu hidroksiurea. Senyawa 1-(4-klorobenzoil)-1,3-dimetilurea dengan potensi aktivitas sitotoksik ini dapat menjadi agen antikanker yang potensial. Kata kunci: 1-(4-klorobenzoil)-1,3-dimetilurea, molecular docking, sintesis, aktivitas sitotoksik, hidroksiurea A novel 1-(4-chlorobenzoyl)-1,3-dimethylurea has been designed, synthesized, structurally determined, and the in vitro cytotoxic activity was evaluated. Docking simulation was performed to position this compound into the Checkpoint kinase 1 (Chk1) active site to determine the probable binding model. Synthesis of 1-(4-chlorobenzoyl)-1,3-dimethylurea was completed by acylation reaction between 1,3-dimethylurea and 4-chlorobenzoyl chloride. The purity of synthesized product was determined by Thin Layer Chromatography. Structure identification was performed by UV spectrophotometer, FT-IR and NMR spectrometer. Antiproliferative assay result demonstrated that this compound possessed good cytotoxic activity against HeLa cells, which is comparable to the positive control, hydroxyurea. This compound with potent cytotoxic activity might be a potential anticancer agent. Keywords: 1-(4-chlorobenzoyl)-1,3-dimethylurea, molecular docking, synthesis, cytotoxic activity
PENGARUH LOKASI DAN PELARUT PENGEKSTRAKSI TERHADAP KANDUNGAN FITOKIMIA DAN AKTIVITAS ANTIOKSIDAN EKSTRAK PEGAGAN (Centella asiatica L. Urb)
Authors: Artanti Nina , Dewi Rizna Triana , Maryani Faiza
Published: December 2018

Pegagan (Centella asiatica Linn Urb.) merupakan jenis tanaman yang biasa digunakan dalam industry farmasi dan kosmetik.Penelitian ini ditujukan untuk mengevaluasi pengaruh tiga lokasi asal sampel dan tiga jenis larutan pengekstraksi (methanol, etanol 96% (v/v), dan etanol 70% (v/v)) terhadap aktivitas antioksidan herbal pegagan (Centella asiaticaLinn Urb).Sampel pegagan yang digunakan pada peneltian ini berasal dari Lembang, Bandung, dan Solo.  Pada ekstrak yang diperoleh dilakukan penentuan kadar fenol total, flavonoid total, dan triterpenoid total. Aktivitas antioksidan dari ekstrak dievaluasi berdasarkan metoda peredaman radikal bebas 2,2-diphenyl-1-picrylhydrazyl (DPPH).  Hasil yang diperoleh menunjukkan bahwa simplisia pegagan asal Lembang yang diekstrak dengan etanol 70% mempunyai aktivitas antioksidan tertinggi serta kandungan fenol total dan flavonoid total tertinggi. Sedangkan simplisia pegagan asal Bandung yang diekstrak dengan pelarut metanol memiliki kandungan triterpenoid total tertinggi tetapi memiliki kandungan fenol total dan flavonoid total serta aktivitas antioksidan yang terendah.  Hasil analisa statistik menunjukkan bahwa lokasi asal simplisia pegagan dan polaritas pelarut yang digunakan untuk ekstraksi secara signifikan (p<0,05) mempengaruhi kandungan fenol total, flavonoid total dan triterpenoid total serta aktivitas antioksidan dari ekstrak pegagan.Kata kunci: ekstrak pegagan, antioksidan, polaritas pelarut Pegagan (Centella asiatica Linn Urb.) is a plant species that commonly used in the pharmaceutical and cosmetic industry. Objective of this study is to evaluate the effect of different source location and solvent polarity for the extraction to the content of total phenolic, total flavonoid total triterpenoids as well as antioxidanti activity of pegagan ((Centella asiatica (Linn.) Urb.)extracts.  Pegagan materials for this study are from three different locations: Bandung, Lembang and Solo.  Based on polarity differences methanol, ethanol 96% and ethanol 70% were used as solvent for extraction.  Antioxidant activity of the extract was evaluated based on the method of 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity.  Results showed that the highest total phenolic content and flavonoid content and antioxidant activity were from 70% ethanol extract from Lembang. Materials from Bandung extracted with methanol gave the highest content of total triterpenoid, however has the lowest content of total phenolic, total flavonoid and antioxidant activity.  Statistic  analysis showed that there is significant differences (p<0,05) of results of total phenolic, total flavonoid, total triterpenoid and antioxidant activity due to source location and solvent polarity. Keywords:Centella asiatica (Linn.) Urb extract, antioxidant, polarity solvent
PENENTUAN SISI AKTIF SELULASE ASPERGILLUS NIGER DENGAN DOCKING LIGAN
Authors: Nauli Tigor
Published: December 2018

Letak dari sisi aktif selulase Aspergillus niger, yang akan menentukan aktivitas katalitiknya, dapat diketahui melalui komputasi. Sebuah ligan selobiosa dimodelkan untuk dapat melakukan simulasi docking pada molekul selulase yang telah diketahui struktur kristalnya. Melalui kalkulasi energi ikatan dan pendekatan optimasi memakai algoritma genetik Lamarckian, dapat dipilih konformasi molekul yang menunjukkan adanya daerah tertentu dengan energi terendah. Struktur yang memiliki daerah semacam ini dianggap mewakili konfigurasi terbaik terikatnya ligan pada sisi aktif yang dicari.Hasil perhitungan memperlihatkan bahwa tekukan protein yang membentuk celah konkaf diantara dua kelompok struktur b-sheet yang saling berlawanan arah pada molekul selulase merupakan sisi aktif dari enzim tersebut. Ligan dapat terikat disana melalui interaksi hidrofilik dengan residu asparagin (Asn20), serin (Ser111), dan glutamin (Gln158). Di salah satu ujung sisi aktif selulase terdapat residu aspartat (Asp99) dan glutamat (Glu116, Glu204) yang akan mempengaruhi aksi katalitik dari enzim selulase apabila residu-residu ini terikat oleh ion-ion divalen.Sisi aktif selulase ini merupakan gabungan dari domain pengikat substrat dan domain katalitik. Penambahan ion logam yang tepat pada sisi aktif enzim selulase Aspergillus niger dapat meningkatkan aktivitas spesifiknya.Kata kunci:docking, ligan, selulase, sisi ikatan, substrat The active site of cellulase from Aspergillus niger that affects the enzyme activity can be searched by computational methods. A ligand of cellobiose is modelled to perform docking simulation to cellulase with known crystal structure. By calculating the binding free energy and optimization approach using Lamarckian's genetic algorithm, a molecular conformation that has a region with the lowest energy value can be selected. The molecule structure with such region represents the best configuration of ligand bound to the active site.The calculation results that the concave cleft formed by protein folding of two anti-parallel b-sheet structures is the active site of the enzyme. A ligand would bind to the site through hydrophilic interactions with asparagine (Asn20), serine (Ser111), and glutamine (Gln158) residues. The aspartic acid (Asp99) and glutamic acid (Glu116, Glu204) residues that reside in one end of the active site determine the catalytic actions of the enzyme when they are binding with some metal ions.It is shown that the active site of this cellulase has substrate-binding domain and catalytic domain together. The introduction of specific metal ions to the active site of Asperillus niger cellulase will increase its specific activity.Keywords: binding site, cellulase, docking, ligand, substrate
Antimicrobial Activity of Selenium Nanoparticles Synthesized by Actinomycetes Isolated from Lombok Island Soil Samples
Authors: Ratnakomala Shanti , Sari Nurul Fitri , Fahrurrozi Fahrurrozi , Lisdiyanti Puspita
Published: December 2018

AbstractA total of 98 actinomycetes were isolated from the soil and litter samples collected from the cacao and coffee plantation in Lombok Island, West Nusa Tenggara, Indonesia. These isolates were screened for their antimicrobial activity. Among 98 isolated strains, only 24 isolates showed antimicrobial activity against test microorganisms of which 20.4% were active against Bacillus subtilis BTCC B-612, 14.3% against Staphylococcus aureus BTCC B-611, and 5.1% against Escherichia coli BTCC B-609. Out of these 24 isolates, 3 were found to be able to grow in medium containing 3 mM Selenium oxide of which the culture were changed color to red. Two of the best strains, L-155 and L-156, were selected for assessing production of Selenium nanoparticles. Bioreduction of selenium nanoparticles was confirmed by UV–visible spectrophotometer which showed peak between 300 and 320 nm. Biosynthesized selenium nanoparticle from isolate actinomycetes L-155 and L-156 were found to have a broad spectrum of activity against the tested microorganisms: Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Micrococcus luteus, and Candida albicans. This study showed rapid and eco-friendly synthesis of selenium nanoparticles from soil actinomycetes. Most of these active isolates revealed to possess antibacterial property.
Preparation and Characterization of Polyhedral Octaphenylsilsesquioxane Modified Castor oil based Polyurethane
Authors: Wen Yue , Jiang Pingping , Huang Jie , Haryono Agus , Deng Jianneng , Cao Zhiliang
Published: December 2018

Vegetable oil-based polyurethanes were synthesized using castor oil (CO) as feedstock, which were characterized by their environmental friendly and renewable properties. Aiming to compensate for shortcomings of these materials, a series of polyurethane/polyhedral octaphenylsilsesquioxane (OPS) hybrids with different OPS contents were prepared by physical mixing in the solutions. Thereafter?chemical structure?morphology and thermal properties of hybrids were characterized through Fourier transform infrared spectrometer (FTIR), scanning electron microscope (SEM), differential scanning calorimetry (DSC), thermal gravimetric analyzer (TGA), tensile test techniques and static contact angle. The results show that the hybrid polyurethanes display both enhanced glass transition temperatures (Tg), initial decomposition temperature (Td5) and tensile strength with low OPS contents. While with high contents?these values decline with the severe aggregation of nano-particles as shown in the SEM images. Meanwhile, the hybrid polyurethanes displayed enhanced surface hydrophobicity as the contact angle with water revealed
MENJADI BINTANG ATAU BINATANG Analisis Wacana “Othering” dalam Film “The Greatest Showman”
Authors: Muthia Sayekti Devi Nirmala
Published: December 2018

This paper is aimed to analyse critically towards a film entitled “The Greatest Showman” related to its content which is problematic in its way to represent those “unique” persons. This film is created based on true story about P. T. Barnum, a politician and a business man in performing arts production. As a text in the cultural studies, this movie brings a discourse that can show how the reality is, especially in the field of entertainment and performing arts business. People considered as a “unique,” or maybe “weird,” always be narrated as the other, beyond the normal. They will be shown as an object to be laughed. From this point, I employed critical discourse analysis from Norman Fairclough, concerning in language used within this movie. We, then, would see how those “unique” persons will be placed as the other in very subtile way.
KEBERTAHANAN KULTURAL DAN RELIGI DI AREA PERMUKIMAN TERDAMPAK BENCANA LUMPUR LAPINDO SIDOARJO, JAWA TIMUR
Authors: Ekawati June
Published: December 2018

Indonesia is a disaster-prone country, therefore efforts for Disaster Risk Reduction are very useful to do.This paper aims to examine the cultural and religious roles of settlement in areas affected by the Lapindo mudflow disaster in Sidoarjo. The method used in this study is the study of relevant literature from research that has been done before. From the results of the literature review, it was concluded that culture and religion became capital for the people who were maintained even though their settlements were now scattered. Culture and religion also become identities which are very influential factors for the resilience of settlements which up to now still have vulnerability, so that anticipation and adaptation need to be carried out as preparedness for possible future disasters.
PANGGUNG KEINDONESIAAN Berebut atau Berbagi?
Authors: Sutrisno S. J. Mudji
Published: December 2018

This article discourses an imagined society along with real practices on mutual respect to become Indonesia. The article explicates the essence of cultural Nusantara in comparison with republic Indonesia. As a case of point of the practices, the articles take the life wisdom of the religions in Indonesia; how the wisdom is relevant to the culture of Nusantara. Besides that, the article gives the illustration of how art workers give their best for Nusantara and respect each other for Indonesia. Lastly, the article questions the willingness of the citizen of Republic of Indonesia: whether or not they are ready to share all resources in the country for the sake of the future generation
TRANSFORMASI SOSIAL-BUDAYA MASYARAKAT INDONESIA
Authors: Kistanto Nurdien Harry
Published: December 2018

Social scientists have conceptualized several stages of sociocultural transformation as societal development. One version modified in this article constitutes a typology of preindustrial and industrial societies which consists of one, hunting & gathering societies; two, pastoral societies; three, village agrarian societies; four, advanced traditional agrarian societies; and five, industrial societies; and six, postindustrial societies. To analyse the sociocultural transformation which happens in the Indonesian society, one has to observe and consider the long historical background which produces social heterogeneity. Thus, the direction and ideals of sociocultural transformation can be identified and conceptualized.
MHD slip flow of chemically reacting UCM fluid through a dilating channel with heat source/sink
Authors: Pravin Kashyap K. , Ojjela Odelu , Das Samir Kumar
Published: December 2018

The present article explores the effects of uniform heat source and first order destructive chemical reaction on an upper convected Maxwell fluid through an expanding or contracting channel with the porous slip condition at the upper plate. It is assumed that the fluid is sucked or injected through the upper plate. The temperature and concentration at the plates is maintained constant. Using suitable similarity transformations, nonlinear coupled ODEs are developed from the governing PDEs. The subsequent ODEs are converted into a first order system and integrated via shooting method. The effect of various prominent parameters on heat, flow and mass transfer characteristics are studied in detail through graphs and tables. The present results suggest that the presence of chemical reaction and heat source yields in the reduction of concentration and of the enhancement of temperature the fluid. It is also observed that the wall expansion shows an increasing effect on the radial velocity component, but the slip parameter exhibits an opposing effect. The viscous case has been studied as a special case where the present results are found to be close to the earlier ones. The flow of such nonlinear viscoelastic fluids has important applications in separation processes like petroleum and medical industries.
The inverse and derivative connecting problems for some hypergeometric polynomials
Authors: Bedratyuk L. , Bedratuyk A.
Published: December 2018

Given two  polynomial sets $\{ P_n(x) \}_{n\geq 0},$ and $\{ Q_n(x) \}_{n\geq 0}$  such that $\deg ( P_n(x) ) = \deg ( Q_n(x) )=n.$ The so-called connection problem between them asks to find coefficients  $\alpha_{n,k}$ in the expression $\displaystyle Q_n(x) =\sum_{k=0}^{n} \alpha_{n,k} P_k(x).$ The connection problem for  different types of polynomials has a long history, and it is still of interest. The connection coefficients play an important role in many problems in pure and applied mathematics, especially in combinatorics, mathematical physics and quantum chemical applications. For the particular case $Q_n(x)=x^n$  the connection problem  is called the inversion problem associated to $\{P_n(x)\}_{n\geq 0}.$ The particular case $Q_n(x)=P'_{n+1}(x)$ is called the derivative connecting problem for polynomial family $\{ P_n(x) \}_{n\geq 0}.$ In this paper, we give a closed-form expression of the inversion and the derivative coefficients for hypergeometric polynomials of the form $${}_2 F_1 \left[ \left. \begin{array}{c} -n, a \\ b \end{array} \right | z \right], {}_2 F_1 \left[ \left. \begin{array}{c} -n, n+a \\ b \end{array} \right | z \right], {}_2 F_1 \left[ \left. \begin{array}{c} -n, a \\ \pm n +b \end{array} \right | z \right],$$ where $\displaystyle {}_2 F_1 \left[ \left. \begin{array}{c} a, b \\ c \end{array} \right | z \right] =\sum_{k=0}^{\infty} \frac{(a)_k (b)_k}{(c)_k} \frac{z^k}{k!},$ is the Gauss hypergeometric function and $(x)_n$ denotes the Pochhammer symbol defined by $$\displaystyle  (x)_n=\begin{cases}1, n=0, \\x(x+1)(x+2)\cdots (x+n-1) , n>0.\end{cases}$$ All polynomials are considered over the field of real numbers.