bluuebunny/crossref_metadata_2025 huggingface dataset:
Distributions of recorded pain in mental health records: a natural language processing based study
Authors: Chaturvedi Jaya , Stewart Robert , Ashworth Mark , Roberts Angus
Published: April 2024

Objective

The objective of this study is to determine demographic and diagnostic distributions of physical pain recorded in clinical notes of a mental health electronic health records database by using natural language processing and examine the overlap in recorded physical pain between primary and secondary care.

Design, setting and participants

The data were extracted from an anonymised version of the electronic health records of a large secondary mental healthcare provider serving a catchment of 1.3 million residents in south London. These included patients under active referral, aged 18+ at the index date of 1 July 2018 and having at least one clinical document (≥30 characters) between 1 July 2017 and 1 July 2019. This cohort was compared with linked primary care records from one of the four local government areas.

Outcome

The primary outcome of interest was the presence of recorded physical pain within the clinical notes of the patients, not including psychological or metaphorical pain.

Results

A total of 27 211 patients were retrieved. Of these, 52% (14,202) had narrative text containing relevant mentions of physical pain. Older patients (OR 1.17, 95% CI 1.15 to 1.19), females (OR 1.42, 95% CI 1.35 to 1.49), Asians (OR 1.30, 95% CI 1.16 to 1.45) or black (OR 1.49, 95% CI 1.40 to 1.59) ethnicities, living in deprived neighbourhoods (OR 1.64, 95% CI 1.55 to 1.73) showed higher odds of recorded pain. Patients with severe mental illnesses were found to be less likely to report pain (OR 0.43, 95% CI 0.41 to 0.46, p<0.001). 17% of the cohort from secondary care also had records from primary care.

Conclusion

The findings of this study show sociodemographic and diagnostic differences in recorded pain. Specifically, lower documentation across certain groups indicates the need for better screening protocols and training on recognising varied pain presentations. Additionally, targeting improved detection of pain for minority and disadvantaged groups by care providers can promote health equity.
Sleep and circadian biomarkers of postoperative delirium (SLEEP-POD): protocol for a prospective and observational cohort study
Authors: Sugg Elizabeth , Gleeson Elizabeth , Baker Sarah N , Li Peng , Gao Chenlu , Mueller Ariel , Deng Hao , Shen Shiqian , Franco-Garcia Esteban , Saxena Richa , Musiek Erik S , Akeju Oluwaseun , Xie Zhongcong , Hu Kun , Gao Lei
Published: April 2024

Introduction

Surgical patients over 70 experience postoperative delirium (POD) complications in up to 50% of procedures. Sleep/circadian disruption has emerged as a potential risk factor for POD in epidemiological studies. This protocol presents a single-site, prospective observational study designed to examine the relationship between sleep/circadian regulation and POD and how this association could be moderated or mediated by Alzheimer’s disease (AD) pathology and genetic risk for AD.

Methods and analysis

Study staff members will screen for eligible patients (age ≥70) seeking joint replacement or spinal surgery at Massachusetts General Hospital (MGH). At the inclusion visit, patients will be asked a series of questionnaires related to sleep and cognition, conduct a four-lead ECG recording and be fitted for an actigraphy watch to wear for 7 days before surgery. Blood samples will be collected preoperatively and postoperatively and will be used to gather information about AD variant genes (APOE-ε4) and AD-related pathology (total and phosphorylated tau). Confusion Assessment Method-Scale and Montreal Cognitive Assessment will be completed twice daily for 3 days after surgery. Seven-day actigraphy assessments and Patient-Reported Outcomes Measurement Information System questionnaires will be performed 1, 3 and 12 months after surgery. Relevant patient clinical data will be monitored and recorded throughout the study.

Ethics and dissemination

This study is approved by the IRB at MGH, Boston, and it is registered with the US National Institutes of Health on ClinicalTrials.gov (NCT06052397). Plans for dissemination include conference presentations at a variety of scientific institutions. Results from this study are intended to be published in peer-reviewed journals. Relevant updates will be made available on ClinicalTrials.gov.

Trial registration number

NCT06052397.
Feasibility of a screening and prevention procedure for risks associated with dysphagia in older patients in geriatric units: the DYSPHAGING pilot study protocol
Authors: Durlach Olivier , Tripoz-dit-Masson Stéphanie , Massé-Deragon Nicolas , Subtil Fabien , Niasse-Sy Zeinabou , Herledan Chloé , Guittard Laure , Goldet Karine , Merazga Salima , Chabert Margaux , Suel Anne , Dayde David , Merdinian Marion , Falandry Claire
Published: April 2024

Background

Dysphagia, particularly sarcopenic dysphagia, is frequent in frail older patients. Sarcopenic dysphagia is a swallowing disorder caused by sarcopenia, corresponding to a loss of muscle mass and strength. It frequently leads to inhalation and to the decrease of food intake, leading the patient to enter a vicious circle of chronic malnutrition and frailty. The awareness of the major health impacts of sarcopenic dysphagia is recent, explaining a low rate of screening in the population at risk. In this context, methods of prevention, evaluation and intervention of sarcopenic dysphagia adapted to the most at-risk population are necessary.

Methods

The DYSPHAGING (dysphagia & aging) pilot study is a prospective, multicentre, non-comparative study aiming to estimate the feasibility of an intervention on allied health professionals using the DYSPHAGING educational sheet designed to implement a two-step procedure ‘screen–prevent’ to mitigate swallowing disorders related to sarcopenic dysphagia. After obtaining oral consent, patients are screened using Eating Assessment Tool-10 Score. In case of a score≥2, procedures including positional manoeuvres during mealtimes, food and texture adaptation should be implemented. The primary endpoint of the study is the feasibility of this two-step procedure (screening–prevention measures) in the first 3 days after patient’s consent.

The study will include 102 patients, with an expected 10% rate of non-analysable patients. Participants will be recruited from acute geriatric wards, rehabilitation centres and long-term care units, with the hypothesis to reach a feasibility rate of 50% and reject a rate lower than 35%.

Ethics and dissemination

The study protocol was approved according to French legislation (CPP Ile-de-France VII) on 15 February 2023. The results of the primary and secondary objectives will be published in peer-reviewed journals.

Trial registration number

NCT05734586.
Patient preferences in genetic newborn screening for rare diseases: study protocol
Authors: MARTIN Sylvia , Angolini Emanuele , Audi Jennifer , Bertini Enrico , Bruno Lucia Pia , Coulter Joshua , Ferlini Alessandra , Fortunato Fernanda , Frankova Vera , Garnier Nicolas , Grauman Åsa , Gross Edith , Hauber Brett , Hansson Mats , Kirschner Janbernd , Knieling Ferdinand , Kyosovksa Gergana , Ottombrino Silvia , Novelli Antonio , Raming Roman , Sansen Stefaan , Saier Christina , Veldwijk Jorien
Published: April 2024

Introduction

Rare diseases (RDs) collectively impact over 30 million people in Europe. Most individual conditions have a low prevalence which has resulted in a lack of research and expertise in this field, especially regarding genetic newborn screening (gNBS). There is increasing recognition of the importance of incorporating patients’ needs and general public perspectives into the shared decision-making process regarding gNBS. This study is part of the Innovative Medicine Initiative project Screen4Care which aims at shortening the diagnostic journey for RDs by accelerating diagnosis for patients living with RDs through gNBS and the use of digital technologies, such as artificial intelligence and machine learning. Our objective will be to assess expecting parent’s perspectives, attitudes and preferences regarding gNBS for RDs in Italy and Germany.

Methods and analysis

A mixed method approach will assess perspectives, attitudes and preferences of (1) expecting parents seeking genetic consultation and (2) ‘healthy’ expecting parents from the general population in two countries (Germany and Italy). Focus groups and interviews using the nominal group technique and ranking exercises will be performed (qualitative phase). The results will inform the treatment of attributes to be assessed via a survey and a discrete choice experiment (DCE). The total recruitment sample will be 2084 participants (approximatively 1000 participants in each country for the online survey). A combination of thematic qualitative and logit-based quantitative approaches will be used to analyse the results of the study.

Ethics and dissemination

This study has been approved by the Erlangen University Ethics Committee (22–246_1-B), the Freiburg University Ethics Committee (23–1005 S1-AV) and clinical centres in Italy (University of FerraraCE: 357/2023/Oss/AOUFe and Hospedale Bambino Gesu: No.2997 of 2 November 2023, Prot. No. _902) and approved for data storage and handling at the Uppsala University (2022-05806-01). The dissemination of the results will be ensured via scientific journal publication (open access).
Effects of combined cognitive and resistance training on physical and cognitive performance and psychosocial well-being of older adults ≥65: study protocol for a randomised controlled trial
Authors: Aminirakan Deniz , Losekamm Björn , Wollesen Bettina
Published: April 2024

Introduction

With increasing life expectancy of older adult population, maintaining independence and well-being in later years is of paramount importance. This study aims to investigate the impact of three distinct interventions: cognitive training, resistance training and a combination of both, compared with an inactive control group, on cognitive performance, mobility and quality of life in adults aged ≥65 years.

Methods and analysis

This trial will investigate healthy older adults aged ≥65 years living independently without cognitive impairments. Participants will be randomly assigned to one of four groups: (1) cognitive training, (2) resistance training, (3) combined cognitive and resistance training, and (4) control group (n=136 participants with 34 participants per group). The interventions will be conducted over 12 weeks. The cognitive training group will receive group-based activities for 45–60 min two times a week. The resistance training group exercises will target six muscle groups and the combined group will integrate cognitive tasks into the resistance training sessions. Primary outcomes are: Short Physical Performance Battery, Sit-to-Stand Test, Montreal Cognitive Assessment, Trail Making Test and Stroop Test combined with gait on a treadmill (dual task). Life satisfaction will be measured by the Satisfaction With Life Scale. Secondary outcomes encompass hand grip strength and the Functional Independence Measure.

Ethics and dissemination

Ethical approval was provided by the local Ethics Committee at the University of Hamburg (no. 2023_009). Informed consent will be obtained from all study participants. The results of the study will be distributed for review and discussion in academic journals and conferences.

Trial registration number

DRKS00032587.
Moral distress measurement in animal care workers: a systematic review
Authors: Baysal Yigit , Goy Nastassja , Hartnack Sonja , Guseva Canu Irina
Published: April 2024

Objectives

The mental health of veterinary and other animal health professionals is significantly impacted by the psychological stressors they encounter, such as euthanasia, witnessing animal suffering and moral distress. Moral distress, initially identified in nursing, arises when individuals are aware of the right action but are hindered by institutional constraints. We aimed to review existing research on moral distress scales among animal care workers by focusing on the identification and psychometric validity of its measurement.

Design

Two-step systematic review. First, we identified all moral distress scales used in animal care research in the eligible original studies. Second, we evaluated their psychometric validity, emphasising content validity, which is a critical aspect of patient-reported outcome measures (PROMs). This evaluation adhered to the Consensus-based Standards for the Selection of Health Measurement Instruments (COSMIN). The results were reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses.

Data sources

PubMed, EMBASE and PsycINFO to search for eligible studies published between January 1984 and April 2023.

Eligibility criteria for selecting studies

We included original (primary) studies that (1) were conducted in animal care workers; (2) describing either the development of a moral distress scale, or validation of a moral distress scale in its original or modified version, to assess at least one of the psychometric properties mentioned in COSMIN guidelines.

Data extraction and synthesis

Two independent reviewers used standardised methods to search, screen and code included studies. We considered the following information relevant for extraction: study reference, name and reference of the moral distress scale used, psychometric properties assessed and methods and results of their assessments. The collected information was then summarised in a narrative synthesis.

Results

The review identified only one PROM specifically adapted for veterinary contexts: the Measure of Moral Distress for Animal Professionals (MMD-AP), derived from the Measure of Moral Distress for Healthcare Professionals (MMD-HP). Both MMD-HP and MMD-AP were evaluated for the quality of development and content validity. The development quality of both measures was deemed doubtful. According to COSMIN, MMD-HP’s content validity was rated as sufficient, whereas MMD-AP’s was inconsistent. However, the evidence quality for both PROMs was rated low.

Conclusion

This is the first systematic review focused on moral distress measurement in animal care workers. It shows that moral distress is rarely measured using standardised and evidence-based methods and that such methods should be developed and validated in the context of animal care.

PROSPERO registration number

CRD42023422259.
Anesthesia start time documentation accuracy where peripheral nerve block is the primary anesthetic
Authors: Stone Alexander B , Zorrilla Vaca Andrés , Lirk Philipp , Gerner Philipp , Vlassakov Kamen
Published: April 2024

Introduction

When used as the primary anesthetic, nerve blocks are not billed as separate procedures. In this scenario, the anesthesia start (AStart) time should include the block procedural time. We measured how often AStarttime was documented before the nerve block was placed in the preoperative area, and compared cases where a block team performed the nerve block and cases where the intraoperative anesthesia attending supervised the nerve block. We hypothesized that the involvement of a regional anesthesia team would lead to more accurate documentation of AStart. We also estimated the lost revenue due to inaccurate start time documentation.

Methods

The study population were patients undergoing surgery with a peripheral nerve block as the primary anesthetic. For this analysis, AStartoccurring less than 10 min before the in-operating room time was defined as potentially inaccurate. Lost potential revenue was estimated by taking the difference between the documented time of local anesthetic administration and the documented AStarttime.

Results

A total of 745 cases were analyzed. Overall, 439 cases (58%) cases were identified as having potentially inaccurate start times. There were higher rates of inaccurate AStartdocumentation by the block team (316/482, 65.5%) compared with blocks supervised by the in-room anesthesia attendings (123/263, 46.7%, p<0.001). Overall, the estimated loss in billable revenue during the study period was a total of $70 265.

Conclusions

The performance of primary regional anesthesia procedure by a block team increased the incidence of inaccurate documentation and uncaptured potential revenue. There is need for education about accurate nerve block documentation for anesthesiologists, especially when separate teams are used.
Real-time Neural Appearance Models
Authors: Zeltner Tizian , Rousselle Fabrice , Weidlich Andrea , Clarberg Petrik , Novák Jan , Bitterli Benedikt , Evans Alex , Davidovič Tomáš , Kallweit Simon , Lefohn Aaron
Published: April 2024

We present a complete system for real-time rendering of scenes with complex appearance previously reserved for offline use. This is achieved with a combination of algorithmic and system level innovations.

Our appearance model utilizes learned hierarchical textures that are interpreted using neural decoders, which produce reflectance values and importance-sampled directions. To best utilize the modeling capacity of the decoders, we equip the decoders with two graphics priors. The first prior—transformation of directions into learned shading frames—facilitates accurate reconstruction of mesoscale effects. The second prior—a microfacet sampling distribution—allows the neural decoder to perform importance sampling efficiently. The resulting appearance model supports anisotropic sampling and level-of-detail rendering, and allows baking deeply layered material graphs into a compact unified neural representation.

By exposing hardware accelerated tensor operations to ray tracing shaders, we show that it is possible to inline and execute the neural decoders efficiently inside a real-time path tracer. We analyze scalability with increasing number of neural materials and propose to improve performance using code optimized for coherent and divergent execution. Our neural material shaders can be over an order of magnitude faster than non-neural layered materials. This opens up the door for using film-quality visuals in real-time applications such as games and live previews.
Proving Correctness of Parallel Implementations of Transition System Models
Authors: de Boer Frank , Johnsen Einar Broch , Pun Violet Ka I , Tapia Tarifa Silvia Lizeth
Published: April 2024

This article addresses the long-standing problem of program correctness for programs that describe systems of parallel executing processes. We propose a new method for proving correctness of parallel implementations of high-level models expressed as transition systems. The implementation language underlying the method is based on the concurrency model of actors and active objects. The method defines program correctness in terms of a simulation relation between the transition system that specifies the program semantics of the parallel program and the transition system that is described by the correctness specification. The simulation relation itself abstracts from the fine-grained interleaving of parallel processes by exploiting a global confluence property of the concurrency model of the implementation language considered in this article. As a proof of concept, we apply our method to the correctness of a parallel simulator of multicore memory systems.
Reordering Functions in Mobiles Apps for Reduced Size and Faster Start-Up
Authors: Hoag Ellis , Lee Kyungwoo , Mestre Julian , Pupyrev Sergey , Zhu Yongkang
Published: April 2024

Function layout, also known as function reordering or function placement, is one of the most effective profile-guided compiler optimizations. By reordering functions in a binary, compilers can improve the performance of large-scale applications or reduce the compressed size of mobile applications. Although the technique has been extensively studied in the context of large-scale binaries, no study has thoroughly investigated function layout algorithms on mobile applications.

In this article, we develop the first principled solution for optimizing function layouts in the mobile space. To this end, we identify two key optimization goals: reducing the compressed code size and improving the cold start-up time of a mobile application. Then, we propose a formal model for the layout problem, whose objective closely matches our goals, and a novel algorithm for optimizing the layout. The method is inspired by the classic balanced graph partitioning problem. We have carefully engineered and implemented the algorithm in an open-source compiler, Low-level Virtual Machine (LLVM). An extensive evaluation of the new method on large commercial mobile applications demonstrates improvements in start-up time and compressed size compared to the state-of-the-art approach.

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Digital Lovers and Jealousy: Anticipated Emotional Responses to Emotionally and Physically Sophisticated Sexual Technologies
Authors: Prochazka Ashton , Brooks Robert C.
Published: April 2024

Technologies that stimulate human social and sexual impulses could affect users and societies. Here, we report on two experiments designed to test participant responses to (1) “virtual friend” chatbots that vary in capacity to engage users socially and emotionally (i.e., emotional sophistication) and (2) “digital lover” technologies—in the form of sex toys, sex robots, or virtual reality entities—that vary in capacity to physically stimulate users (i.e., physical sophistication). Participants (173 female, 176 male) read vignettes that each described a particular technology and then answered whether, if their romantic partner were to use the described technology, they would anticipate jealousy or anger, and whether they would prefer to see the technology banned. Participant anticipations of jealousy and anger were so similar that we combined them in a single composite measure. In experiment 1, both the anticipation of jealousy-anger and the inclination to ban chatbots increased with emotional sophistication, particularly in female participants. In experiment 2, both sexes anticipated greater jealousy-anger and were more inclined to ban more physically sophisticated digital lovers. Female participants expressed higher levels of both responses across the range of sophistication. Experiment 2 participants were more likely to anticipate jealousy-anger and more inclined to ban sex robots than sex toys or virtual reality lovers. Our results show only limited consistency with evolutionary theories concerning sex differences in jealousy. Generally, the anticipated levels of jealousy-anger and inclination to ban the described technologies were low, suggesting low levels of resistance to the idea of the technologies.
Effect of Topically Applied Milrinone or Nitroglycerin on Internal Mammary Artery Free Flow
Authors: Izzat Ahmad Walid , Aissami Salman , Saadoun Rakan , Izzat Mohammad Bashar
Published: April 2024

Background. Surgical mobilization of the internal mammary artery (IMA) can induce graft vasospasm, which is commonly managed by wrapping the IMA in a vasodilator‐soaked swab before grafting. However, the choice of the most effective topical vasodilator remains the subject of continued investigation. We carried out a prospective randomized controlled trial to compare the effect of topically applied milrinone, nitroglycerin, and normal saline on IMA free flow. Methods. Forty‐six consecutive patients undergoing elective primary coronary artery bypass grafting were enrolled. After the left IMA was harvested, free flow was measured under controlled hemodynamic conditions before any intervention (flow 1) and at a mean of 12.5 minutes after the topical application of one of three agents (milrinone, nitroglycerin, or normal saline) on the IMA (flow 2). Results. All agents induced a significant increase in IMA flow, and flow 2 was significantly higher in the nitroglycerin and milrinone groups compared to the normal saline group, even while controlling for flow 1 as a centered continuous variable. Nevertheless, there was no statistically significant difference in flow 2 between the nitroglycerin and milrinone groups. Conclusions. Topically applied milrinone and nitroglycerin can increase blood flow of the IMA significantly in the early period after surgical mobilization. IMA blood flow was greater after the topical application of milrinone compared to nitroglycerin, but this has failed to reach statistical significance in the present study setting. This trial is registered with NCT06301880.
Human Placental Mesenchymal Stem Cells‐Exosomes Alleviate Endothelial Barrier Dysfunction via Cytoskeletal Remodeling through hsa‐miR‐148a‐3p/ROCK1 Pathway
Authors: Lv Yuzhen , Yu Wenqin , Xuan Ruiui , Yang Yulu , Xue Xiaolan , Ma Xiaowei
Published: April 2024

Background. Endothelial barrier disruption of human pulmonary vascular endothelial cells (HPVECs) is an important pathogenic factor for acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). Mesenchymal stem cells‐exosome (MSCs‐Exo) represents an ideal carrier for cell‐free therapy. The therapeutic implication and underlying mechanism of human placental MSCs‐Exo (HPMSCs‐Exo) in ALI/ARDS need to be further explored. Materials and Methods. HPMSCs‐Exo was extracted from HPMSCs and characterized. Then, the therapeutic effects of exosomes were evaluated in ALI mice and HPVECs. RNA‐sequencing was applied to reveal the miRNA profile of HPMSCs‐Exo and differentially expressed genes (DEGs) in HPMSCs‐Exo‐pretreated HPVECs. The targets of miRNAs were predicted by bioinformatics methods and correlated to DEGs. Finally, the role of hsa‐miR‐148a‐3p/ROCK1 pathway in HPVECs has been further discussed. Results. The results showed that HPMSCs‐Exo could downregulate Rho‐associated coiled‐coil‐containing protein kinase 1 (ROCK1), upregulate the expression of zonula occludens‐1 (ZO‐1) and F‐actin, promote HPVECs migration and tube formation, reduce cytoskeletal disorders and cell permeability, and thus improve ALI/ARDS. RNA‐sequencing revealed the DEGs were mainly enriched in cell junction, angiogenesis, inflammation, and energy metabolism. HPMSCs‐Exo contains multiple miRNAs which are associated with cytoskeletal function; the expression abundance of hsa‐miR‐148a‐3p is the highest. Bioinformatic analysis identified ROCK1 as a target of hsa‐miR‐148a‐3p. The overexpression of hsa‐miR‐148a‐3p in HPMSCs‐Exo promoted the migration and tube formation of HPVECs and reduced ROCK1 expression. However, the overexpression of ROCK1 on HPVECs reduced the therapeutic effect of HPMSCs‐Exo. Conclusions. HPMSCs‐Exo represents a protective regimen against endothelial barrier disruption of HPVECs in ALI/ARDS, and the hsa‐miR‐148a‐3p/ROCK1 pathway plays an important role in this therapeutics implication.
A Case of Pancreatic Neuroendocrine Tumor with Liver Metastases Demonstrating the Possibility of Enhanced ACTH Production by the SACI Test
Authors: Mori Hirozumi , Tamura Masashi , Ogawa Ryo , Kimata Yuta , Endo Sho , Sekine Katsutoshi , Kodama Sayuri , Watanabe Hiromi Hisazumi , Ookuma Kiyoshi , Jinzaki Masahiro
Published: April 2024

Objective. ACTH-producing pancreatic NETs have a propensity to metastasize, and in patients with metastases, there is no established method yet to precisely determine if the excess ACTH is produced by the primary or the metastatic tumors. Localizing the source of production of ACTH in such cases is important for devising suitable treatment strategies and evaluating the benefit of local therapies from the viewpoint of control of Cushing’s syndrome. Methods. We performed the selective arterial calcium injection (SACI) test combined with selective portal and hepatic venous sampling in a 32-year-old female patient with ectopic ACTH-producing pancreatic NET and liver metastases. Results. The blood level of ACTH after Ca loading was significantly elevated only in the vessels thought to be directly feeding the pancreatic tumor, and Ca loading from any artery did not significantly increase ACTH concentrations in the hepatic veins compared to the main trunk of the portal vein. Conclusions. The present case demonstrates that there might be an ACTH-producing p-NET that responds to Ca loading. Further in vitro studies are required to validate this possibility.
Evaluation of Setting Time, Flowability, Film Thickness, and Radiopacity of Experimental Monocalcium Silicate‐Based Root Canal Sealers
Authors: Juntha Sukanya , Tungsawat Pakit , Wongwatanasanti Ninnita , Suksaphar Warattama , Lertnantapanya Siripat
Published: April 2024

Introduction. This study aimed to evaluate the efficacy of a formulation of premixed calcium silicate‐based sealer (CSBS) with monocalcium silicate (Mono‐CS) as the main component. Its properties were compared with those of a control group (iRoot SP) according to ISO 6876/2012 standards for root canal sealers. Materials and Methods. The CSBS formulation consisted of two components (powder and liquid). The powder was a mixture of Mono‐CS, a radiopacifier, and a thickening agent, and the liquid components were nonaqueous liquid agent and setting accelerator. Three formulation groups with different powder–liquid ratios were prepared: group A, 2 : 1; group B, 3 : 1; and group C, 2 : 1, which also contained calcium chloride as a setting accelerator. The setting time, flow rate, film thickness, and radiopacity of the three CSBS groups and the control group were evaluated and compared. Each test was repeated five times for each group. Results. The minimum values of setting time (i.e., working time, initial setting time, and final setting time) were ranked in order of significance as group B, the control group, group C, and group A. The control group had the lowest film thickness at 20 μm, with a nonsignificant difference to group C. The flow rates in group A, group C, and the control group were >20 mm. Furthermore, the experimental groups showed a similar amount of radiopacity as the control group (p  > 0.05). Conclusion. Mono‐CS and calcium chloride can be used in the formulation of root canal sealers, and their properties, including working time, initial setting time, final setting time, flow rate, film thickness, and radiopacity, are consistent with those of iRoot SP and ISO 6876/2012 standards.
A Case of Interrupted Aortic Arch in an Adult: An Unsuspected Cause of Uncontrolled Hypertension
Authors: Dibaba Abdi Dandena , Bekele Abenezer Kebede , Gebrewahd Selam Hagos
Published: April 2024

In this paper, we describe an incidentally discovered case of interrupted aortic arch in a 28-year-old male patient with a history of long-standing poorly controlled hypertension. The patient presented to the hospital with a complaint of upper respiratory complaints and long-standing chest pain. A plain chest radiograph was requested to exclude a diagnosis of pneumonia, and the radiography spotted an incidental finding of inferior rib notching. A subsequent CT angiography was done for further characterization, and a diagnosis of interrupted aortic arch was confirmed. Therefore, although rare, IAA should be considered in adults with refractory hypertension or unexplained congestive heart failure.
Dynamic Modeling and Active Vibration Control of Piezoelectric Laminated Structure Based on Macrofiber Composite
Authors: Luo Haitao , Li Huadong , Wu Xingyuan , Liu Guangming , Zhang Wei
Published: April 2024

In this paper, a ground‐based experimental system for solar array active vibration suppression has been established. Firstly, in order to establish an accurate model of the solar array, the solar array is regarded as a flexible cantilevered thin plate, and the corresponding dynamical equations are derived using the absolute nodal coordinate method. In addition, in this paper, the more advanced MFC piezoelectric patch is used instead of the traditional PZT piezoelectric ceramic patch. The electromechanical coupling finite element model of the P1‐type MFC patch is established and substituted into the kinetic equation of the solar array. Finally, the accuracy of the electromechanical coupling modeling and the control effect of active vibration suppression were verified using the PID control. A set of experimental frameworks for evaluating the active vibration suppression effect, including the free vibration test, sinusoidal perturbation test, and white noise perturbation test, as well as the analysis strategy of the test data, are established.
The SOS1 Inhibitor MRTX0902 Blocks KRAS Activation and Demonstrates Antitumor Activity in Cancers Dependent on KRAS Nucleotide Loading
Authors: Sudhakar Niranjan , Yan Larry , Qiryaqos Fadia , Engstrom Lars D. , Laguer Jade , Calinisan Andrew , Hebbert Allan , Waters Laura , Moya Krystal , Bowcut Vickie , Vegar Laura , Ketcham John M. , Ivetac Anthony , Smith Christopher R. , Lawson J. David , Rahbaek Lisa , Clarine Jeffrey , Nguyen Natalie , Saechao Barbara , Parker Cody , Elliott Adam J. , Vanderpool Darin , He Leo , Hover Laura D. , Fernandez-Banet Julio , Coma Silvia , Pachter Jonathan A. , Hallin Jill , Marx Matthew A. , Briere David M. , Christensen James G. , Olson Peter , Haling Jacob , Khare Shilpi
Published: April 2024

KRAS is the most frequently mutated oncogene in human cancer and facilitates uncontrolled growth through hyperactivation of the receptor tyrosine kinase (RTK)/mitogen-activated protein kinase (MAPK) pathway. The Son of Sevenless homolog 1 (SOS1) protein functions as a guanine nucleotide exchange factor (GEF) for the RAS subfamily of small GTPases and represents a druggable target in the pathway. Using a structure-based drug discovery approach, MRTX0902 was identified as a selective and potent SOS1 inhibitor that disrupts the KRAS:SOS1 protein–protein interaction to prevent SOS1-mediated nucleotide exchange on KRAS and translates into an anti-proliferative effect in cancer cell lines with genetic alterations of the KRAS–MAPK pathway. MRTX0902 augmented the antitumor activity of the KRAS G12C inhibitor adagrasib when dosed in combination in eight out of 12 KRAS G12C–mutant human non–small cell lung cancer and colorectal cancer xenograft models. Pharmacogenomic profiling in preclinical models identified cell cycle genes and the SOS2 homolog as genetic co-dependencies and implicated tumor suppressor genes (NF1 and PTEN) in resistance following combination treatment. Lastly, combined vertical inhibition of RTK/MAPK pathway signaling by MRTX0902 with inhibitors of EGFR or RAF/MEK led to greater downregulation of pathway signaling and improved antitumor responses in KRAS–MAPK pathway–mutant models. These studies demonstrate the potential clinical application of dual inhibition of SOS1 and KRAS G12C and additional SOS1 combination strategies that will aide in the understanding of SOS1 and RTK/MAPK biology in targeted cancer therapy.
Percepciones sociales de la pobreza en habitantes de una localidad en zona fronteriza.
Authors: Galvis Velandia Laura Nataly , Carvajal García Carolina , Jaimes Marquez Maritza Carolina
Published: April 2024

Este articulo presenta los resultados de la investigación titulada Percepciones sociales
sobre pobreza en el barrio La Fortaleza del municipio de San José de Cúcuta, adscrita
al macroproyecto La Migración: Pobreza, Desarrollo y Factores Psicosociales, de la
facultad de Educación, Artes y Humanidades de la Universidad Francisco de Paula
Santander. La investigación tuvo como eje principal el análisis de las percepciones
sociales sobre migración y pobreza en el barrio La Fortaleza del municipio de San José
de Cúcuta; por tal motivo, se consideró oportuno desarrollarla bajo el paradigma cualitativo y desde un enfoque fenomenológico. Este análisis aportó una mirada sobre la
pobreza, que servirá para la actuación y obtención de nuevo conocimiento para los
investigadores sociales, y que gestó insumos valiosos al Grupo de Investigación de
Trabajo Social (GITS) desde la línea de problemas regionales y fronterizos.
Descrição de um novo gênero e uma nova espécie de tingitídeo (Hem.)
Authors: Monte Oscar
Published: April 2024

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Contribuição ao conhecimento dos flebótomos de São Paulo. V. Descrição do macho de P. monticolus Costa Lima, 1932 e de duas novas espécies
Authors: Barretto M. Pereira , Coutinho J. O.
Published: April 2024

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Nótulas sôbre Leptobyrsa steini (Stål)
Authors: Monte Oscar
Published: April 2024

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Notas sôbre Streblidae. I. Sôbre a verdadeira identidade de Trichobius dugesii Towns, 1891
Authors: Guimarães Lindolpho R.
Published: April 2024

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Contribuição ao conhecimento dos flebótomos de São Paulo. VI. Descrição de duas novas espécies (Diptera, Psychodidae)
Authors: Barretto M. Pereira , Coutinho J. O.
Published: April 2024

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Sobre a nidificação de Poliocephalus dominicus speciosus (Arribalzaga)
Authors: Pinto Oliverio
Published: April 2024

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Notas sobre as aves mencionadas por Pero Vaz de Caminha
Authors: Pinto Oliverio
Published: April 2024

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Uma nova espécie do gênero "Monalonion" Herr.-Schaeffer (Hemiptera – Miridae)
Authors: Monte Oscar
Published: April 2024

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Nova espécie do gênero Basilia (Nycteribiidae – Diptera) do Brasil
Authors: Guimarães Lindolpho R.
Published: April 2024

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Sobre alguns gêneros e espécies de Heptapsogastridae (Mallophaga) – I
Authors: Guimarães Lindolpho R.
Published: April 2024

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Nuevas especies de hesperidos brasileños
Authors: Hayward Kenneth J.
Published: April 2024

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Sobre algumas espécies de pulgas brasileiras
Authors: Guimarães Lindolpho R.
Published: April 2024

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Os myriápodes e suas relações com a agricultura. Com uma bibliografia completa sobre o assunto
Authors: Schubart Otto
Published: April 2024

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Alguns Tomísidas e um Saltícida novos do Brasil
Authors: Soares B. M.
Published: April 2024

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Sobre as espécies do gênero Pseudolipeurus (Mallophaga – Philopteridae)
Authors: Guimarães Lindolpho R.
Published: April 2024

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Dois novos gêneros de malófagos de Psitacídeos exóticos
Authors: Guimarães Lindolpho R.
Published: April 2024

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Sôbre os Menoponidae (Mallophaga) encontrados em Tinamiformes
Authors: Guimarães Lindolpho R.
Published: April 2024

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Sôbre as aves do distrito de Monte Alegre, município de Amparo (São Paulo, Brasil)
Authors: Pinto Oliverio
Published: April 2024

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Mais alguns opiliões de Boracéa
Authors: Soares B. M.
Published: April 2024

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Interessante anomalia em um Cosmosoma teuthras (Walker, 1854) (Lepid.: Ctenuchidae Kirby, 1837)
Authors: Travassos Filho Lauro
Published: April 2024

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Opiliões do Alto da Serra. I
Authors: Soares B. M.
Published: April 2024

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Notas sôbre opiliões
Authors: Soares B. M.
Published: April 2024

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Alguns reparos a "Notas sôbre opiliões – V a XIII"
Authors: Soares B. M.
Published: April 2024

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Sôbre a nomenclatura de alguns grupos superiores da ordem Lepidoptera. 3ª nota: Famílias Lemoniidae, Megalopygidae e superfamília Eucleoidea
Authors: D'Almeida R. Ferreira
Published: April 2024

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Um novo opilião da Bahia
Authors: Soares B. M.
Published: April 2024

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Nota suplementar à "Revisão das especies americanas da superfamilia Danaoidea"
Authors: D'Almeida R. Ferreira
Published: April 2024

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Um novo malófago do surucuá Trogonurus aurantius (Spix)
Authors: Guimarães Lindolpho R.
Published: April 2024

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Sôbre a validez de Fulcidax violaceus (Klug, 1824) (Col. Fulcidacidae)
Authors: Navajas E.
Published: April 2024

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Notas sôbre a Ofiologia Neotrópica e Brasílica. IV. Da invalidez da espécie Bothrops pessoai A. Prado, 1939
Authors: Amaral Afrânio do
Published: April 2024

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Sôbre as datas de publicação das "Mélanges Orthoptérologiques", de Henri de Saussure, com referências a ordem Mantodea Burmeister, 1838
Authors: Travassos Filho Lauro
Published: April 2024

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Alguns opiliões da coleção "Otto Schubart"
Authors: Soares B. M.
Published: April 2024

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Alguns Philopteridae (Mallophaga) de tinamiformes
Authors: Guimarães Lindolpho R.
Published: April 2024

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Relação de alguns dípteros capturados em Monte Alegre, estado de São Paulo
Authors: Carrera Messias
Published: April 2024

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Elateridae (Col.) de Monte Alegre com a descrição de uma espécie nova
Authors: Navajas E.
Published: April 2024

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Fulcidacidae (Col.) de Monte Alegre com a descrição de uma espécie nova
Authors: Navajas E.
Published: April 2024

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Dois novos gêneros e três novas espécies de opiliões brasileiros
Authors: Soares Hélia Eller Monteiro
Published: April 2024

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Novo gênero de opilião do Paraná coligido pelo Sr. Hatschbach
Authors: Soares B. A. M.
Published: April 2024

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Nota suplementar aos nossos trabalhos sôbre os gêneros Pseudopieris, Anteos, Appias e Aphrissa (Lep. Pierididae)
Authors: D'Almeida R. Ferreira
Published: April 2024

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New or little-know Tipulidae (Diptera) from São Paulo, Brasil – Part II
Authors: Alexander Charles P.
Published: April 2024

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Angiopolybia nom. n., para o conceito revalidado de "Stelopolybia Ducke, 1914" (Hym. – Vespidae – Polybiinae)
Authors: Araujo R. L.
Published: April 2024

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Sôbre os tipos e a sinonímia de alguns Canthonini (Col. Scarabaeidae)
Authors: Lane Frederico
Published: April 2024

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Novos opiliões do estado do Espírito Santo coligidos na Fazenda Chaves (Opiliones – Gonyleptidae)
Authors: Soares Benedicto A. M. , Soares Hélia E. M.
Published: April 2024

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Notas de nomenclatura. I. Estado atual dos gêneros Methysia Butler. 1876, e Metamya, novo nome para Paramya Druce, 1898 (Lep.: Ctenuchidae)
Authors: Travassos Filho Lauro
Published: April 2024

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Regressão do pêso sôbre o comprimento em Bothrops jararaca e sua variação sexual e estacional
Authors: Vanzolini P. E.
Published: April 2024

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Duas novas espécies de Cyrtidae (Diptera) do Brasil
Authors: Carrera Messias
Published: April 2024

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Pequenas notas sôbre Asilidae (Diptera). III. Redescrição de Dissmeryngodes anticus (Wied.) e descrição do alótipo de Othoniomyia triangularis Hermann (Laphriinae, Atomosiini)
Authors: Carrera Messias
Published: April 2024

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Opiliões paranaenses da coleção Joram Leprevost (Opiliones – Gonyleptidae)
Authors: Soares Benedicto A. M. , Soares Hélia E. M.
Published: April 2024

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Espécies neotropicais da família Simuliidae Schiner (Diptera, Nematocera). III. Simulium botulibranchium Lutz, 1910 e Simulium travassosi, n. sp.
Authors: D'Andretta Maria A. V. , D'Andretta Jr. Carlos
Published: April 2024

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Redescrição de Gigantodax wrighti (Vargas, Martínez e Díaz, 1944) (Diptera, Simuliidae)
Authors: D'Andretta Maria A. V. , D'Andretta Jr. Carlos
Published: April 2024

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Notas sinonímicas
Authors: Monte Oscar
Published: April 2024

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Pequenas notas sôbre malofagos. I
Authors: Guimarães Lindolpho R.
Published: April 2024

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Segunda relação de alguns Asilidae (Diptera) e suas presas, com a descrição prévia de duas novas espécies
Authors: Carrera Messias
Published: April 2024

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Nota nomenclatural sôbre Leimadophis almada (Wagler, 1824) (= Leimadophis almadensis Auct.)
Authors: Vanzolini P. E.
Published: April 2024

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Nova espécie de Ubatubesia Soares, 1945, e alótipo de Wygodzinskyia viridiornata Soares et Soares, 1945 (Opiliones – Gonyleptidae)
Authors: Soares Benedicto A. M. , Soares Hélia E. M.
Published: April 2024

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Sôbre o gênero Leptopteromyia Williston, 1908 (Diptera, Asilidae)
Authors: Carrera Messias
Published: April 2024

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Notas bionômicas sôbre meliponíneos (Hymenoptera, Apoidea). II. Sôbre a pilhagem
Authors: Nogueira-Neto Paulo
Published: April 2024

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Redescrição e novo nome genérico para Coelonotus fissilis Mir.-Rib., 1920
Authors: Bokermann Werner C. A.
Published: April 2024

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Sobre as espécies brasileiras de Systropus Wiedemann, 1830 (Diptera, Bombyliidae)
Authors: Carrera Messias , D'Andretta Maria A. V.
Published: April 2024

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Sôbre as variações das asas do vomer nos macacos do gênero "Cebus"
Authors: Serra Octavio Della
Published: April 2024

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Contribuição para o conhecimento da família Mydaidae. Gêneros: Mydas F., 1794 e Messiasia, n. gen. (Diptera)
Authors: D'Andretta Maria A. V.
Published: April 2024

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Notas sobre os mamíferos obtidos pela expedição do Instituto Butantã ao rio das Mortes e serra do Roncador
Authors: Vieira Carlos O. da C.
Published: April 2024

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Aves do Itatiaia. Lista remissiva e novas achegas à avifauna da região
Authors: Pinto Olivério
Published: April 2024

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Sobre algumas vespas parasitas da família Ichneumonidae (Hymenoptera)
Authors: Lima A. da Costa
Published: April 2024

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Nova contribuição à ornitologia do rio das Mortes. Resultados da expedição conjunta do Instituto Butantan e Departamento de Zoologia
Authors: Pinto Olivério M. de O. , Camargo Eurico A. de
Published: April 2024

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Microhylidae da coleção do Departamento de Zoologia (Amphibia-Anura)
Authors: Bokermann Werner C. A.
Published: April 2024

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Resultados de uma expedição científica ao território do Acre: Mamíferos
Authors: Vieira Carlos da C.
Published: April 2024

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Nova espécie do gênero Paraleptastacus Wilson 1932 (Cocepoda, fam. Canthocamptidae)
Authors: Carvalho J. de Paiva
Published: April 2024

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Riccia, novo gênero para Corematura aliaria (Druce, 1890) e descrição do alótipo dessa espécie (Lep. Ctenuchidae)
Authors: Travassos Filho Lauro
Published: April 2024

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Protozoários parasitas do diplópodo brasileiro Rhinocricus padbergi Verhoeff 1938 das das chácaras de São Paulo
Authors: Mello I. Froilano de
Published: April 2024

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Asilideos do Peru (Diptera)
Authors: Carrera Messias , D'Andretta Maria A. V.
Published: April 2024

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Resultados ornitológicos de uma expedição ao território do Acre pelo Departamento de Zoologia
Authors: Pinto O. M. de O. , Camargo E. A. de
Published: April 2024

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Novos gêneros e espécies de coleoptera Lymexylonidae e notas sôbre Melittomma Murray, 1867
Authors: Lane Frederico
Published: April 2024

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Cerambycoidea neotropica nova. III. (Coleoptera)
Authors: Lane Frederico
Published: April 2024

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Ocorrência de Carapus Raf. (= Fierasfer Oken) no Brasil (Teleostei – Carapidae)
Authors: Lopez Ana Amélia Ancona
Published: April 2024

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Genero Paracanthon (Coleoptera, Scarabaeidae)
Authors: D'Andretta M. A. V. , Martinez A.
Published: April 2024

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A flora na alimentação das aves brasileiras. II. Alimentação da codorna (Nothura maculosa maculosa) (Temm., 1815)
Authors: Jimbo Sachiko
Published: April 2024

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Sobre uma coleção de aves da região de Cachimbo (sul do estado do Pará)
Authors: Pinto Oliverio M. de Oliveira , Camargo Eurico A. de
Published: April 2024

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Notas para o estudo dos Pygidiidae brasileiros (Pisces – Pygidiidae). VI
Authors: Ribeiro Paulo de Miranda
Published: April 2024

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Notas de Acarologia. XL. Acaros do estado do Maranhão
Authors: Fonseca Flavio da
Published: April 2024

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Inervação dos dentes mandibulares no Bradypus tridactylus L.
Authors: Monteiro Moacyr Pinheiro
Published: April 2024

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Ibidionini (Coleoptera, Cerambycinae). I. Generos de escapo cicatricoso
Authors: Martins Ubirajara R.
Published: April 2024

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Genitalia de Parastagmatopera unipunctata (Burm., 1838) (Mantodea)
Authors: Heitzmann Therezinha J.
Published: April 2024

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Ibidionini (Coleoptera, Cerambycinae). IV. Comentarios, redescrição e especies novas do genero Hexoplon Thomson
Authors: Martins Ubirajara R.
Published: April 2024

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Ibidionini (Coleoptera, Cerambycinae). XI. Gêneros de pronoto enrugado
Authors: Martins Ubirajara R.
Published: April 2024

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Ibidionini (Coleoptera, Cerambycidae). VI. Gêneros de corpo parcialmente seríceo-piloso
Authors: Martins Ubirajara R.
Published: April 2024

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Ibidionini (Coleoptera, Cerambycinae). XIV. Novas espécies dos gêneros Heterachthes e Octoplon
Authors: Martins Ubirajara R.
Published: April 2024

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Ibidionini (Coleoptera, Cerambycidae). VII. Gênero Phormesium Thomson – breves comentários e espécies novas
Authors: Martins Ubirajara R.
Published: April 2024

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Bipartição dos os Zygomaticum e ocorrência dos Arcus Maxillo-Temporalis Infra-Jugalis nos Ceboidea (Primates, Mammalia)
Authors: Francisco Mário de
Published: April 2024

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Estudos sôbre a regeneração das pernas do Triatoma infestans (Klug, 1834) (Hemiptera, Reduviidae)
Authors: Corrêa Fernando M. A.
Published: April 2024

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Sobre las especies brasileras del genero Amblyopinodes Seevers, 1955, con descripcion de dos nuevas especies (Col., Staphylinidae)
Authors: Machado-Allison C. E.
Published: April 2024

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Nova espécie de Chlamisus (Coleoptera, Chrysomelidae) (3ª contribuição)
Authors: Bokermann Werner C. A.
Published: April 2024

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Bostrichidae (Coleoptera). I. Notas sôbre Bostrychopsis neotropicais com descrição de uma nova espécie
Authors: Reichardt Hans
Published: April 2024

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Bostrichidae (Coleoptera). III. Novo gênero e espécie da subtribu Xyloperthina
Authors: Reichardt Hans
Published: April 2024

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