bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of artificial neural networks in estimating the number of species in benthic communities
Authors: Neto Antônio Pelli- , Hayashi Carmino , de Oliveira Giovana Barbosa , Pimenta Paloma Cristina , Pelli Afonso
Published: December 2021

The least squares method has been largely used in several areas, mainly because of its simplicity. It is a widely used knowledge tool. However, the current advances in Information Technology have contributed to the development of decision support systems, in a search for greater reliability of predictions from samples. The use of Information Technology in Limnology is still limited. The main objective of this study is to show the possibility of using Artificial Neural Network in the process of inference of the total number of the rate of biological communities from samples. Our data show that the use of nonparametric inference, along with nonlinear data mapping, may lead to more consistent and efficient results, as the Artificial Neural Networks.
Healing through the landscape
Authors: Golubchikov Yuri N
Published: December 2021

This study investigates the significance of landscape therapy under the impact COVID-19 pandemic. Deurbanization and social distancing drives many city dwellers to their second homes (dacha) in the countryside or stimulates house trade and construction in the rural areas. This expands the possibilities of the body’s recovery. One of the main methods is landscape therapy, along with the cultivation of their own agricultural products by the townspeople in the landscape-geochemical environment familiar to them. Of all natural components, water (natural mineral waters, mud, lakes, rivers, streams, waterfalls) has the greatest importance in the healing landscape concept. It is predicted that the COVID-19 pandemic should be perceived as a milestone in the reorientation of geography and ecology towards understanding human society in a continuous transformation.
Characterization of an area susceptible to floods and inundations in a medium size city in Southern Brazil
Authors: Júnior Sidnei Matana , Casiraghi Yohan , Berres Gabriela Weimer , Leite Frandoloso Marcos Antonio , Rosa Francisco Dalla
Published: December 2021

The change in precipitation patterns that has occurred over the past decades establishes the discussion about the risks arising from rainfall in urban areas. These risks include floods, inundations and overflow, which are influenced by different conditions. The purpose of this work is to characterize a risk area, susceptible to inundations and floods, in the city of Passo Fundo, in the south of Brazil. In order to propose solutions aimed at mitigating risks for the area, a GIS (Geographic Information System) characterization was applied to prepare thematic maps to identify conditions of infrastructure networks, as well as other constraints of the built environment. The analysis showed that the area, predominantly residential, is currently susceptible to environmental risks, given the proximity to streams, the topography with slopes and impermeable surfaces, despite the existence of rain network infrastructure. Furthermore, the mitigation strategies were proposed, based on the concept of green infrastructure such as the implementation of draining surfaces, rain gardens and a linear park. The data collected in this study will provide subsidies to elaborate the risk maps of the area, deepening the analysis in future studies, assisting the decision making of the public power to prevent and mitigate risks such as floods, according to the identified vulnerability, as well as contribute to Goal 11 - Sustainable cities and communities on the United Nations Agenda 2030.
Model of transfection in human endometrial epithelium cells with hsa-miR-191-5p Model of transfection in human endometrial epithelium cells with hsa-miR-191-5p
Authors: Acuna-Gonzalez Ricardo Josue , Lara-Pereyra Irlando , Gonzalez- Azpeitia Diego Ivan , Garcia-Lopez Guadalupe , Flores Herrera Hector
Published: December 2021

Background: Human endometrial cells are important in blastocyst recognition and implantation. We have recently shown that miR-191-5p secreted into culture medium by human embryos cultured and transferred to woman on the fifth day of development was associated with the percentage of pregnant vs. non-pregnant patients. Little is known about the regulation and expression of endometrial miRNAs induced by embryonic miRNAs in endometrial tissue. Therefore, in the present work we explored the viability and transfection of RL95-2 endometrial cell line with agomiR-191. Results: The main results obtained in this study were: First, transfection of RL95-2 cell line with 100nM of lipofectamine in combination with 15, 30, and 60 nM of agomiR-191 for 3, 6 and 24 hours does not affect the viability of RL95-2 cells. Second, we observed expression of miR-191 with 60 pmol of agomiR-191 in a time dependent transfection. Conclusion:: Stimulation of RL95-2 endometrial cell line with lipofectamine does not modify their viability. The transfected RL95-2 endometrial cells showed increased the expression of miR-191.
An unusual case of a neonate with left sided type 3 poland syndrome with dextrocardia
Authors: Tali Showkat Hussain , Ashraf Bhat Mohd , Hassan Zul Eidain , Haasan v Jawaid , Yousuf Shagufta , Ahmad Sheikh Mushtaq
Published: December 2021

Poland syndrome (PS) is right sided in 75 percent of cases. Only 10 percent are associated with dextrocardia. It is usually detected late for the milder nature of the condition. Only in severe cases it comes to attention during neonatal period. Left sided Poland syndrome with dextrocardia is extremely rare. To the best of our knowledge this is the first case of left sided type 3 Poland syndrome with dextrocardia diagnosed at birth with chest wall getting sucked in and bulging out during inspiration and expiration respectively
Spontaneous isolated intraperitoneal rupture of urinary bladder after normal vaginal delivery presenting as puerperal sepsis
Authors: Singla Rimpi , Arora Aashima , Bora Girdhar , Gupta Nalini
Published: December 2021

Spontaneous isolated intraperitoneal rupture of urinary bladder is a rare urological complication of normal delivery. This complication is usually related to prolonged labour, failure to empty bladder in second stage of labour, use of forceps/ ventouse, postpartum urinary retention, vaginal birth after caesarean section and usually presents immediately after delivery. We report the case of a patient with spontaneous isolated intraperitoneal rupture of urinary bladder after normal vaginal delivery in the absence of any risk factor. She presented on day 5 postpartum with features suggestive of puerperal sepsis with pyoperitoneum with acute kidney injury. Absence of unhealthy lochia and later, normal-looking uterus and adnexa during laparotomy led to the suspicion of alternate cause for seropurulent ascites. Further exploration revealed rent in the urinary bladder with necrosed margins. High index of suspicion of alternate diagnosis should be maintained if some of the clinical findings are not supportive of provisional initial diagnosis
Evaluation of the surgeon’s workplace in elective procedures: a descriptive study in two Brazilian public hospitals
Authors: de Araujo Francisca Miranda , Lopes Diniz Raimundo , Sardinha Ana Hlia dee Lima , Barros Rubenio
Published: December 2021

The surgeon is exposed to ergonomic constraints (physical and mental) that may influence on his health from aspects related to physical posture during work to psychological problems arising from the management conditions in the operating room settings. This study evaluates the working conditions during elective surgeries in two Brazilian Public Hospitals. Field observations and a questionnaire were performed. The results indicated dissatisfaction and risks regarding the discomfort/pain, Physical/Environmental, Organizational/Management, and Psychosocial factors.
Modelling profile of onchocerca volvulus glutamatecysteine ligase (ONCVO-GCL)
Authors: Roland Akinseye Olanrewaju , Morayo Ale E , Joan Ojomo , Folawiyo I Gbadamosi , Kayode Ebenezer , Mustapha Adelabu
Published: December 2021

Onchocerca volvulus Glutamate cysteine ligase (ONCVO-GCL) catalyzes the first step in the production of the cellular antioxidant glutathione (GSH), which involve the condensation of cysteine and glutamate to form the dipeptide gamma-glutamylcysteine (γ-GC). ONCVO-GCL is critical to cell survival. Its dysregulation could lead to decreased GSH biosynthesis, reduced cellular antioxidant capacity, and the induction of oxidative stress. ONCVO-GCL expression support the high level of cell proliferation and confer resistance to many chemotherapeutic agents, hence could serve as a molecular target for inhibitors. This study aims to model the 3-dimensional (3D) structure of ONCVO-GCL, validate and predict the active sites of the modelled protein. ONCVO-GCL (Uniprot ID: A0A044QR48) 3D structure was modelled and validated using SWISS-MODEL. The Computed Atlas of Surface Topography of proteins (CASTp) 3.0 was used to predict the active sites of the modelled protein. A percentage identity matrix of 41.81% was obtained, which confirms the similarity identity of 40.86% obtained from the homology modelling. Model with 88% in the most favoured region of Ramachandra plot was obtained and the more favourable active sites for docking analyses due to the similarities observed from the alignment of the modelled structure to the template structure were: GLY 2A, LEU3A, LEU 4A, ARG 40A, TRP 47A, GLY 48A, ASP 49A, GLU 50A, GLU 52A, and PRO 109A.
Quantification and speciation of trac. E amount of vanadium (iii) and vanadium (v) using 2-[(e)-[3-[(e)-(2 hydroxyphenyl) methyleneamino]phenyl] iminomethyl]phenol
Authors: C J Okenwa , PO Ukoha , EC Chinyere , E Ezeh
Published: December 2021

Some new transition metal complexes of Vanadium(III) and Vanadium(V) with tetradentate (N2O2) Schiff base – 2-[(E)-[3-[(E)-(2-hydroxyphenyl)methyleneamino]phenyl]iminomethyl]phenol (HPMAPIP) have been synthesized. The characterization of the ligand and the metal complexes were also reported. The bonding and the proposed structure of the newly synthesized complexes were also identified by elemental analysis, Infra red, UV – Vis, 1H NMR, magnetic moment measurements and conductivity analysis. The Metal: Ligand Mole ratio indicated a 1:1 and their wavelength maximum were at 400 and 405 nm for Vanadium (III) and Vanadium(V) complexes respectively. From the calibration curve, Beer’s law was valid for Vanadium (III) and Vanadium (V) between 0.488 – 3.904 ppm. The calibration and analytical sensitivity of Vanadium (III) complex are 0.074 and 0.32 while that of Vanadium (V) are 0.024 and 24 respectively. Optimum pH for the formation of the complex was determined to be 10 and 11 for Vanadium (III) and Vanadium(V) respectively. Very few elements were found to interfere with the method. The method was successfully applied in the determination of Vanadium in alloy steel.
Mitochondrial dysfunctions and neurodegenerative diseases: a mini-review
Authors: Kumari Ratan , Shekhar Nikhila , Tyagi Sakshi , Thakur Ajit Kumar
Published: December 2021

Mitochondrial dysfunction is estimated to be the primary reason involved in different types of neurodegenerative disorders as mitochondria is suggested to be important in the production of reactive oxygen species. Recently, several evidences have emerged out for impaired mitochondrial structures and functions viz. shape, size, fission-fusion, distribution, movement etc. in neurodegenerative diseases especially with Alzheimer’s disease, Parkinson’s disease and Huntington’s disease. Therefore, apart from looking neurodegenerative diseases on the whole, a detailed understanding of the functioning of mitochondria and their role in degeneration would pave new options for the therapy of age-related neurodegenerative diseases.
Quality assurance and quality control. current furtherances and hereafter point of view
Authors: Bereda Gudisa
Published: December 2021

Quality assurance can be delineated as "section of quality management concentrated on furnishing confidence that quality must-have will be performed." The confidence delivered by quality assurance is twice intrinsically to management and extrinsically to clients, government agencies, regulators, certifiers, and third parties. An alternate delineation is "entire the aimed and organized activities accomplishment within the quality method that can be substantiated to hand over confidence that a commodity or service will perform must-have for quality. Quality assurance is across-the-board and does not have to do with the specific must-have of the product being developed. QA hobbies and responsibilities fill in practically entire of the fantabulous technique in lone fashion or distinctive, while QC is a subset of the QA hobbies. Also, constituents in the fantabulous technique might not be concretely substituted by QA/QC hobbies and responsibilities but perhaps enclose QA and QC. Quality control is a procedure which contemplates on performing the quality demand. Quality control intend to distinguish (and dead-on) imperfection in the finished product. Quality control, in consequence, is a reactive procedure. Quality control can be delineated as "section of quality management emphasized on furnishing quality must-have.
Bacteriological profile of pharmaceutical water used for production purpose
Authors: Khan Muddasir
Published: December 2021

Objectives: To determine the bacteriological quality of pharmaceutical water used for production purposes (cosmetics, medicine, etc.). Materials and methods: An experimental study was conducted of 20 pharmaceutical water samples, collected from reputed pharmaceutical companies located in Peshawar, Pakistan. To enumerate the overall microbial load and particular pathogens from the obtained water samples traditional culture and biochemical approaches were used. Results: A total aerobic viable bacterial load of all samples were found below the acceptable limit (200 CFU/mL) while, Pseudomonas species were found (n=03), and Escherichia coli was found (n=01). No evidence of Staphylococcus aureus and Salmonella species were found in any of the samples. Conclusion The current study provides a comprehensive bacteriological profile of pharmaceutical water and demonstrates that the presence of particular bacteria might cause significant toxicity and hazard in final pharmaceutical products.
Protocol on stratigraphic micro-samples from surface finishes obtained at historic-archaeological buenos aires walls for their conservation, technological & archaeometrical analysis
Authors: Alejandra López Mariel
Published: December 2021

This paper presents the trials to establish a protocol to perform and preserve the inclusion in acrylic resin of stratigraphic micro- samples from surface finishes obtained at historic-archaeological brick walls. The aim is to highlight the importance of samples conservation status, same as describing technological and archaeometrical studies of ceramic materials in the Historical Archeology. These stratigraphic micro-samples within acrylic resin could be further analyzed with optical and/or physical-chemical characterization techniques. The surface finishes of brick walls are generally made of various materials framed within a broad concept of ceramic materials, such as: clay, lime and various pigment mixtures, among the main ones. The technological and archaeometrical analysis based on the stratigraphic micro-samples allows the recording and characterizing relationships of strata formed by the progressive accumulation of the different layers of surface and environmental finishes. In addition, this analysis extends to the application techniques for micro-structural, morphological, physical and chemical characterization.
Archeology of tattoos and other brands in the contemporary body: the mystical stigma to body art
Authors: Nunes Junior Ario Borges
Published: December 2021

This study aims to characterize the phenomena of tattoos, piercings and other brands and signals produced along the body length, so expressive among teenagers and young contemporaries, to then relate them to other cultural events involving the body, located in the religious field and the other in the aesthetic: the mystical stigmata and body art, respectively. The three events (tattoos and piercings, body art and mystical stigmata), although in its own way and according to the temporal and ideological circumstances that have defined, show the plastic character of the meat, as a guarantee for the subject of virtual triumph over natural.
Climate variability, disasters and their impacts assessment in Manahari, rural municipality of Makwanpur, Nepal
Authors: Mandal Ram Asheshwar , Subedi Bindu , Adhikari Dhruba Lochan , Mathema Ajay Bhakta
Published: December 2021

Nepal is climatically very sensitive country because of long drought, heavy floods, landslides and soil erosion caused by changing pattern of rainfall and temperature. However, there are very limited studies related to these issues, thus this research was objectively carried out to analyze temperature and precipitation trend of study area, examine the climate pattern and assess the impacts of climate change hazards on different sectors. Ward number 7 and 8 Manahari Rural Municipality of Makwanpur district was selected as the study site. Total 40 households survey, 15 Key informants interview and two focus group discussions were conducted involving the affected local to collect the primary data. Moreover, secondary data specifically monthly maximum and minimum temperature and rainfall for thirty one years between 1985–2015 were gathered from nearest meteorological station i.e. NFI Hetauda Station (Station No. 906) and Manahari Station (Station No. 920). The drought trend was calculated using the ratio of Precipitation<2Temperatures. The theoretical distribution i.e. Gumbel, Log-Pearson and Log Normal models were applied to predict the flood peaks and maximum rainfalls. The mean annual temperature was increasing at the rate of 0.0226°C per year. The highest mean annual temperature was 24.1°C in 2015. It was found that, the number of days exceeding the maximum average temperature in the period of 31 years. However, the trend of total annual precipitation in Hetauda was decreasing at the rate of 5.6607 mm per year. The highest rainfall was recorded about 3323.1 mm in year 2002 and it was the least only 1626.2 mm in 2012. The January, February, March, November and December were the driest months. Flood frequency using Log Pearson showed the highest flood in 1000 years return period. The mean rank was the highest of drought having value 5 while it was the lowest only 1.4 of flood. The slope failure at the edges of the rural roads also causes landslides which also fills the agriculture land. The locals responded that the drainage systems were poor and there were no protection structure and/or biological component to reduce landslide risk during construction periods. Major five disasters were recorded in Manahari during from March to June whereas, wildlife attack throughout the year and so on.
Evaluate the delay in the management of acute abdomen at the Yaounde central hospital: a prospective cohort study
Authors: Ngoumfe Joseph Cyrille Chopkeng
Published: December 2021

Background: Early surgical treatment remains the first factor of good prognosis for the management of acute abdominal diseases. The aim of this study was to evaluate the delay in the management of these pathologies in our context. Material and methods: We conducted a prospective cross-sectional study at the Yaoundé Central Hospital (HCY) over 7 months. All patients over 15 years of age presenting with an acute non-traumatic digestive surgical abdomen were included. The follow-up was done during the entire hospital stay of the patients. The dates and times of the different stages of management were recorded. Results: We collected 63 patients, 37 men, with a sex ratio M/F of 1.42. The mean age was 41.06±18 years. The mean time between arrival in the emergency room and the indication for surgery was 16.9 hours. Acute generalized peritonitis (n=26) was the most common diagnosis with 41.3% of cases. The average time between the indication for surgery and the availability of the surgical kit was 19 hours. The average time between the availability of the operating kit and the start of the surgical procedure was 6.2 hours. The complication rate was 33.3%. The mortality rate was 15.9%. Conclusion: Our delays in the management of acute abdomens are relatively long. A better organisation of the system and continuous training of the medical staff of peripheral hospitals would improve the prognosis of our patients.
Socio-economic profile of arid and semi-arid agropastoral region of Borana rangeland Southern, Ethiopia
Authors: Fenetahun Yeneayehu , Fentahun Tihunie
Published: December 2021

Ethiopia is believed to have the largest livestock population in Africa. This livestock sector has been contributing considerable portion to the economy of the country and Borana zone is the major contributor for this. The main objectives of the study were to make basic information regarding natural features and socio-economic conditions of the zone that serve or stepping ground for planning policy making and research. This data is crucial for designing proper development plan for research activities and decision making. Specifically, the 2019 socio -economic profile was conducted to provide basic information for the 2020 national election purpose and for 2021 population and housing census as preliminary document regarding socio-economic condition of the zone. And also, this socio-economic profile is used to enhance tourism and economic development, identifying under used services (or opportunities for shared services, forecasting problem areas, developing local community profiles and better land use planning. In organizing this document, the serious problems were the absence of reliable data and up to date data and information. The document being the first of its kind gives a general clue about the zone and accordingly could be used as a bench mark for further study about the zone.
Mercury emission from the aluminium industry: a review
Authors: Amano KO Ansah , Ntiri-Asiedu AG
Published: December 2021

There has been a rising global concern of mercury because of its persistent nature, long-range transport and toxicity. Mercury possesses serious health effects on living organisms and the environment. Mercury, mostly in inorganic form, is present in almost all categories of rocks. It may be released through natural occurrences and/or anthropogenic activities such as aluminum production. Stable organic mercury compounds, for example methyl mercury (CH3Hg), are formed by the attachment of mercury to one or two carbon atoms. Depending on the source of bauxite, a substantial amount of elemental mercury is released by aluminum industries. Emitted elemental mercury contributes to increasing global atmospheric reserve of mercury hence decreasing mercury emissions plays a key role in lowering the contribution of anthropogenic activities to the global atmospheric mercury budget. In general, all three forms of mercury (elemental, inorganic and organic mercury) have the potential of causing adverse health effects at sufficiently high doses. Mercury emissions are readily absorbed through the alveoli membranes and gastrointestinal tract affecting other systems. Fetuses and individuals often exposed to mercury (chronic exposure) are two classes of people who are more susceptible to harm caused by mercury. This paper discusses mercury metal and oxide emission from the aluminum industry.
Application of Google earth in carbon assessment and monitoring in agroforestry: a study from Ratanpur, Nepal
Authors: Mandal Ramasheshwar , Karki Srijana , Pandit Bishnu Hari
Published: December 2021

The carbon assessment and monitoring in small scale forests like agroforests are difficult tasks but it creates enormous opportunity as carbon credit. This study aims to assess carbon sequestration potential in agroforestry including soil carbon using google earth imageries. Agroforestry of Ratanpur village in Tanahun district Nepal was selected as the study site. Total agroforests of 19 farmers were selected as the experimental and no agroforests area of 4 farmers were selected as the control site. The high resolution imageries of 2020 and 2015 were acquired from Google earth pro. The digitization was done to classify the image into agriculture, agroforestry, natural trees, settlement areas and others. Total enumeration was done to measure the diameter and height of the plants (tree species) planted in the agro-forest. Moreover, total 69 soil samples were collected from 0-10, 10-20 and 20-30 cm depth. The biomass was calculated using Chave et al. equation while soil carbon was analyzed using Walkley Black method. The biomass was converted into carbon which was used to calculate mean annual carbon increment. The result showed the highest carbon stock was 17.6 kg/ stand of Paulownia tomentosa. Total carbon sequestration potential was 2057.689 kg and its monetary value was US$ 30.863. The mean soil carbon stock of agro-forest was higher 52.92 ton/ha than this of 50.3 ton/ha in agriculture site. The map showed it was 7.63 ha agroforest in map of 2020. The overall accuracy of map of 2015 was 90.91% with Kappa coefficient 0.86 but these values were 80.65% and 0.74 respectively of map of 2020. One-way ANOVA and Post hoc test showed that there was significant difference in species wise carbon stock per stand at 95% confidence level. The research will be useful to understand the carbon stock in agroforestry practices.
Algorithm of management based on treatment goals for calcifying tendonitis of the shoulder: rigidity, pain and size of calcification
Authors: Fernández-Cuadros Marcos Edgar , Albaladejo-Florín María Jesús , Álava-Rabasa Sandra , Pérez-Moro Olga Susana
Published: December 2021

Purpose: The objective of the present manuscript is to propose a step-by-step algorithm for the management of calcifying tendonitis (CT) of the shoulder based on treatment goals, from conservative to surgical approaches. Method: A clinical note to present the main treatments for the management of calcifying tendonitis of the shoulder based on pain, rigidity and size of calcification based on the clinical experience and previous publications of the authors has been performed. Arguments: Treatment is conservative and surgical although there is controversy on the most adequate treatment. Kinesiotherapy is the recommended therapy for shoulder rigidity. For pain management after NSAIDs; microwaves, short waves, TENS, ultrasounds and Interferentials are effective. For the management of size of calcification, Iontophoresis, Electroshock wave therapy, Ultrasound needle guided aspiration and arthroscopic surgeries are the recommended alternatives, in that order. Conclusions: CT of the shoulder must be treated based on specific goals, mainly pain, rigidity or size of calcification. The proposed step-by-step algorithm of treatment is suggested based on the effectiveness of available techniques. If rigidity is present, kinesiotherapy is the recommended technique. For pain management, physical therapy such as microwaves, short waves, TENS, Ultrasound and Interferentials are effective techniques. For the treatment of calcification, iontophoresis is the most common, safe and inexpensive technique. If all previous conservative techniques failed, advanced techniques such as ESWT, US guided aspiration and arthroscopy are recommended, although they are not exempt of risk factors and complications.
Surgical treatment of thalamic fractures treated by anatomic plate with survevent
Authors: K Lahrach , B Soumare , S Sidibe , S Diarra , AR Saeed , F Boutayeb
Published: December 2021

Introduction: Calcaneus fractures are frequent and serious injuries. They represent 65% of tarsal trauma and 2% of all fractures. The thalamic fractures constitute a particular entity by their mechanism of occurrence, by their treatment and by their prognosis much less favorable than the extra-articular fractures.1 Materials and methods: Our series spanning a period of 7 years from January 2011 to November 2018 focused on 12 patients with a thalamic fracture of the calcaneus treated by anatomical plate with bearing, collected in the Orthopedic Trauma Department A of the Hassan II Fez University Hospital. All adult patients with a thalamic calcaneal fracture who had undergone an osteosynthesis using an anatomical plate were included and extra-thalamic fractures and thalamic fractures treated by other therapeutic means or other types of screw plates were excluded. All patients underwent an urgent general systematic examination and a regional examination. On the neurological level, the majority of patients were admitted with a GCS at 15. Results: Our focused on 12 operated patients between the ages of 17 and 53 with an average of 35 years. Our series includes 12 patients including 17 calacneum fractures which are divided into 10 men and 2 women; the male sex represents 83.3%. The preoperative delay was on average 9.25 days with extremes between 03 and 20 days. No thromboembolic complications or algodystrophy were noted in our series. According to Kitaoka's rating, the average score was 73.5%. The functional results were excellent in 47.06% of the cases, good in 23.53% of the cases, average in 23.53% of the cases and poor in 5.88% of the cases. In post-operative the average Bohler angle was 26.5° (15° to 35°) against a pre-operative Bohler angle varying between -7° to 15°. On revision, the average recoil from Bohler's angle finds it to be 21.5°. Conclusion: In the light of all those preceding the surgical treatment of articular fractures of the calcaneus displaced by anatomical plate, despite the risks associated with this technique provides a certain superiority if you are sure you can get a perfect reduction.
Avulsion fracture of the lesser trochanter case report and systemic review
Authors: Bo-Eisa Ahmad N , Alarbash Mohammed S , AL-Buhassah Abdullah , Al Khars Abdullah F
Published: December 2021

Isolated avulsion lesser trochanteric fractures (LTF) are infrequent and happen mainly in adolescent athletes. LFT is a rare fracture the first case has been published by Schlueter et al. Avulsion fractures result when the fracture piece is pulled from its original bone by powerful contraction of a tendon or ligament. We report a case of boy patient with isolated avulsion fracture of the lesser trochanter confirmed by radiological investigation and patient underwent non-operative treatment. We present the first case diagnosed with LTF in our institution.
Knee myopericytoma-case report and literature review
Authors: Rodrigues Susana , Ferreira Catrine , Coelho Tiago , Gaspar Diogo , Fallah Jean , Lino Rui , Geada Nuno
Published: December 2021

Calcinosis cutis is a rare disorder characterized by of deposition of insoluble calcium salts in the skin and subcutaneous tissue. Five subtypes of calcinosis cutis are described: dystrophic, metastatic, idiopathic, iatrogenic, and calciphylaxis.1 Of these subtypes, dystrophic calcinosis (DC) is the most common, and it is the most frequently seen in association with underlying autoimmune connective tissue diseases.2 Dermatomyositis, systemic sclerosis and less commonly systemic lupus erythematous were described to be complicated by DC. However, DC associated with rheumatoid arthritis (RA) is extremely rare.2 The condition causes substantial morbidity and is associated with pain and limitation of movement when the process involves areas close to joints or when ulceration occurs.2 We report a middle age Sudanese woman with good controlled RA who developed dystrophic calcinosis cutis.
Fibrodysplasia ossificans progressiva - a case report with brief literature review
Authors: M Sharique , Siddiqui, Yasir Salam , Abbas Julfiqar Mazhar , MKA Sherwani
Published: December 2021

Fibrodysplasia ossificans progressiva (FOP) is an exceptionally uncommon autosomal dominant genetic disorder characterized by defects in skeletogenesis manifesting as congenital malformations of the great toes and progressive postnatal induction of disabling ectopic endochondral osteogenesis. During early course of disease patients of FOP are often misdiagnosed as having soft tissue sarcoma or aggressive juvenile fibromatosis and hence sometimes undergo invasive procedures that usually lead to the speeding up of disease process. Therefore early correct diagnosis of fibrodysplasia ossificans progressiva is necessary to prevent additional iatrogenic insult. The case study is being presented to highlight the clinical features of fibrodysplasia ossificans progressiva, difficult aspect of diagnosis and management with brief literature review.
Surgical treatments of patients with periprosthetic humeral fracture and comorbidities
Authors: Liu Jiayong , J Roebke Logan , Vander Maten Josh W , Tranovich Meaghan , Ebraheim Nabil A
Published: December 2021

Background: Periprosthetic humeral fractures represent a complex and rare complication. Currently, there is no standardized procedure for management or classification of these fractures. Questions/purposes: This unique case series purpose was to look at surgical outcomes and comorbidity profiles of 10 PHF patients. Subsequent analysis looked at whether these outcomes could add to the discussion of a proposed standard of care in a patient cohort with significant comorbidities. Patients and methods: All patients with humeral fractures from 2008-2019 were analyzed for inclusion. A total of ten patients met the inclusion criteria; humeral fracture concurrent with a shoulder arthroplasty. Each patient was managed surgically using a locking plate with or without cerclage wiring. Outcome analysis was then performed for each patient. Humoral fractures managed conservatively were removed from the dataset along with periprosthetic fractures around an elbow arthroplasty, IM nail, or supracondylar fracture after shoulder arthroplasty. Results: The average union time in all patients was 13.27±2.90 (9.86-17.29) weeks. There was no significant difference between patients treated with cerclage wiring or without. All patients had successful union except for a patient with Osteogenesis Imperfecta. There were two radial nerve palsies. The average Deyo-Charlson score and BMI was 7.1±.84 (4-13) and 29.89 respectively. Conclusion: The treatment of PHFs using the technique of ORIF with locking plate with or without cerclage wiring provides satisfactory outcomes in a patient population that usually includes significant comorbidities. Level of evidence: Therapeutic Study Level IV Retrospective Review.
Posterior tibial slope measurement among Saudi population
Authors: Alsowaigh Mouad , A Arafah Mohammad , Alharbi, Sultan Khaled , Sultan Omar Al , Alshahrani Adel , Hulaibi Fahad H Al
Published: December 2021

To measure the posterior slope of the tibia among the healthy Saudi population using Magnetic Resonance Imaging (MRI). A retrospective study review of 151 knee MRIs at King Khaled University Hospital, Riyadh, Saudi Arabia. All patients with no previous surgical intervention to their knees and did not suffer any bone injury around the knee were included. Three different orthopedic physicians (two senior residents, one orthopedic fellow) measured the posterior tibial slope (PTS) angle for all patients, and their average was taken for all readings using a sagittal T2 MRI cut. Patients with a history of previous surgical intervention to the knee joint, trauma involving distal femur or proximal tibia, osteoarthritis and inflammatory arthritis, and congenital deformities were excluded from the study. The mean age of patients was 28.15 in a range of 15-50 years. The posterior tibial slope mean and the median and the mode were 8.76, 8.73, 7.53, respectively. In addition, the mean angle (degree) in females was 9.69±4.02 and 8.76±4.15 in males. The Maximum and the minimum posterior slope angle calculated in these patients were respectively 19.73 and 0.3 degrees. Our findings are that the mean posterior tibia slope among the Saudi population is 8.76˚. The results showed the difference of PTS in Saudi people comparing to deferent communities. The association between the numbers of the posterior tibial slope with gender was tested and no significant correlation. In this study, we did not calculate weight and height in the cases as independent factors. Because of that, upcoming studies might consider these factors.
Association of ITGB3 gene polymorphisms with the risk of developing fetal growth restriction syndrome
Authors: Aslonova Makhlie Zh , GA Ikhtiyarova , NN Mavlyanova
Published: December 2021

The article presents a molecular genetic study of the ITGB3 gene polymorphism in pregnant women with fetal growth restriction syndrome. Purpose: Assessment of the detectability of the association of the ITGB3 gene polymorphism in women with physiological pregnancy and fetal growth restriction syndrome in the uzbek population of the Bukhara region. Materials and methods: 80 pregnant women were examined during gestation from 8-36 weeks: 40 pregnant women with fetal growth restriction syndrome and 40 women with physiological pregnancy, hospitalized in the department of pathology of pregnant women in the Bukhara city maternity hospital in the city of Bukhara. Conclusion: The study showed that the functionally unfavorable allele C and the association of the T / C genotype polymorphism of the ITGB3 gene polymorphism can be a determinant of an increased risk of developing FGRS in Uzbekistan (χ2 <0.47; P> 0.05).
Expression of circulating Mir-139-5p is associated with Postmenopausal Osteoporosis in Indian women
Authors: BM Rupakala , Anbazhaganb K , Prabhakarac S , Sailakshmia MPA
Published: December 2021

Background: Osteoporosis in post-menopausal women is known to progress periodically and is highly associated with inflammation. MicroRNAs regulate inflammatory process, which may therefore control bone metabolism. Deregulation of miRNAs associated with inflammation may lead to development and progression of osteoporosis. We selected four miRNAs known to be involved in inflammation to test their association with post-menopausal osteoporosis. Methods: We quantified four circulating miRNAs, hsa-miR-139-5p, hsa-miR-342-3p, hsa-miR-146a and hsa-miR-24-3p in plasma samples of 25 post-menopausal osteoporosis and 25 post-menopausal healthy subjects. Related biochemical tests were done using Cobas e411 and ELISA. Results: Upon quantification of circulating miRNAs, we observed that hsa-miR-139-5p was expressed higher in post-menopausal osteoporotic samples (p=0.01). The expression of hsa-miR-24-3p was seen lower in osteoporotic samples though not highly significant (p=0.2). Conclusion: Differential expression of hsa-miR-139-5p and hsa-miR-24-3p was seen in osteoporosis subjects. These miRNA could be significantly involved in development and progression of osteoporosis. Further studies are required to highlight miRNAs’ involvement in regulating bone metabolism, which could be manipulated to use them as marker or therapeutic strategies to alleviate osteoporosis.
Prospective study of the role of HE4 and CA125 in treatment and follow-up in ovarian cancer patients
Authors: Liest MD Ann-Lisbeth , Omran Ahmed Shaker , Mikiver Rasmus , Rosenberg Per , Uppugunduri Srinivas
Published: December 2021

Introduction: Epithelial Ovarian Cancer, tubal- and peritoneal cancer (EOC) is still the major cause of death in gynecological cancer. The outcome of primary surgery is an important prognostic factor. The primary aim of this study was to study the utility of HE4 and CA125 in monitoring the response of chemotherapy during treatment and in predicting prognosis and recurrence during follow-up. We have also evaluated the role of HE4 as a predictor of the result of surgical intervention. Methods: Seventy-eight patients scheduled for chemotherapy were monitored with serum HE4 and CA125 during treatment and follow-up. In 39 patients samples for tumor markers were also obtained prior to surgical intervention. Results: Both HE4 and CA125 decreased in response to treatment. PFS and OS were strongly dependent on HE4 levels prior to start of chemotherapy with significantly prolonged PFS and OS when HE4 levels were under upper reference limit of 82pmol/L (P=0.018 resp. P<0.001). The levels of HE4 correlated with primary surgical outcome with significantly lower postoperative HE4 in the radically operated group (P<0.001). An increase in HE4 and/or CA125, signals a recurrence 3-6months before diagnosis. Median levels for both HE4 and AC125 before start, during and at the end of treatment were significantly higher for platinum resistant patients (P<0.005). Conclusion: Both tumor markers are valuable in monitoring the response of chemotherapy as well as in predicting recurrence during follow-up. Postoperative HE4 holds promise as an objective marker to evaluate the result of surgery and is highly predictive for future prognosis.
Primary ovarian serous psammocarcinoma-a case report with mini literature review
Authors: Baba Tsukasa , Fukagawa Yasuko , Itamochi Hiroaki , Sato Chie , Tomabechi Hidetoshi , Nagasawa Takayuki , Kagabu Masahiro , Shoji Tadahiro , Sugai Tamotsu
Published: December 2021

Serous psammocarcinoma is a rare subtype of serous carcinoma in which a significant number of psammoma bodies are present histologically. Because it is an extremely rare disease, the pathogenesis of the disease remains unclear. Here we present a case of primary ovarian serous psammocarcinoma in which computed tomography (CT) imaging of the abdomen was useful for the diagnosis. A female patient was referred to our department with a complaint of abdominal distention. Pelvic magnetic resonance imaging revealed a multifocal tumor with a papillary enhancement in the right appendicular region, and abdominal CT imaging exhibited marked calcification of the enhancement. She underwent a laparotomy for suspected right ovarian cancer. As postoperative pathological examination revealed dominant stromal infiltration of psammoma bodies beneath peritoneum, this case was diagnosed as primary ovarian serous psammocarcinoma at FIGO Stage IIB. The patient was treated with six courses of paclitaxel plus carboplat in after the surgery. She is currently under outpatient observation without any signs of recurrence after 8 years of treatment. The case of significant calcification of the intra cystic enrichment on CT imaging is considered to be a case of this disease.
Clinical and epidemiological profile of the mother–neonate binomy with microcefalia and suspected infection by zika viruses in the gestation: a sectional study
Authors: Curvelo Sarno Manoel Alfredo , Santos Luciana Carla Belém dos , Ribeiro Lyra Priscila Pinheiro , Mendes Carlos Mauricio Cardeal , Oliveira Patrícia Ribeiro de , Santiago Ana Cecilia Travassos
Published: December 2021

Introduction: The association between the increased incidence of microcephaly and the epidemic outbreak of Zika virus infection (ZIKV) in Brazil between 2015 and 2016 was observed by many authors. World Health Organization declared it as a public health emergency of international concern. Maternal infection with the Zika virus can be transmitted vertically and lead to Congenital Zika Syndrome (CZS) in infants. So that it is important to investigate the clinical-epidemiological profile of the mothers and their newborns. Aims: To characterize the clinical- epidemiological profile of pregnant women associated with presumed ZIKV in pregnancy and their newborns diagnosed with microcephaly at birth and associated with CZS. Methods: A sectional study, using medical record data, between September 2015 and June 2016. Results: 82 cases of microcephaly were reported in maternity during this period. Of these, 32 cases were excluded because they did not fit the new microcephaly criteria according to the World Health Organization (WHO) and the Ministry of Health of Brazil. The mean maternal age was 25 years, varying from 13 and 43 years old; exanthema was the only symptom related to Zika virus infection and it was observed in 60% (27/45) of the pregnancies, which occurred predominantly during the first or the second trimester of pregnancy. Other mothers were asymptomatic. Related to the newborns, 62% (31/50) were female; 32% (16/50) were low weight; 2% (1/50) were premature. Neonatal brain ultrasound showed 70,4% (31/44) of the neonates with abnormal findings, mainly calcifications that occurred in 87% (27/31). 29 newborns were submitted to fundoscopy examinations and 38% (11/29) were abnormal. Conclusion: Despite the majority of pregnant women did not have classic symptoms of arboviruses and because of this the suspicion and confirmation of Zika viruses infection through serologies are difficult in clinical practice, it is important to understand clinical and epidemiological characteristics related to Zika viruses infection and the CZS to allow mapping where preventive measures should be directed and better investigated as well as to offer an adequate follow-up to the infected neonates according to their outcomes.
An improved method for determining the total energy intensity of goods for multi-product productions
Authors:   Institute of General Energy of the National Academy of Sciences of Ukraine, 172 Antonovycha str., Kyiv, 03150, Ukraine, Malyarenko O.Ye. , Stanytsina V.V. ,   Institute of General Energy of the National Academy of Sciences of Ukraine, 172 Antonovycha str., Kyiv, 03150, Ukraine
Published: December 2021

The total energy intensity of goods, labour and services as an indicator of energy efficiency is introduced in DSTU 3682-98 "Methods of determination of total energy cost of goods, labour and services", but some of its components listed in the standard still do not have clear algorithms for determining them. The article provides an overview of changes and extensions to the methodology presented in the articles of scientists of the Institute of General Energy of the National Academy of Sciences of Ukraine, who develop this methodology for more than 20 years. Authors propose such extensions and advancements to the methodology: the calculation algorithm of direct and technological energy intensity of goods production was advanced by the use of proportions for each product for multi-productive technologies, new calculation algorithm is proposed to assess energy intensity of labour and technological assets, also a set of hazardous pollutions was accounted in the method of assessments of abatement technologies energy intensity. The proposed advanced methodology could be used both for existing single- and multi-products technologies retrofit planning and for the design of new technological facilities taking into account a wide range of production factors including impact on the environment. Keywords: energy intensity of products, technology, direct energy intensity, total energy intensity, distribution of common energy costs