bluuebunny/crossref_metadata_2025 huggingface dataset:
Cyclic voltammogram analysis of the 3,3´- (1,4-phenylene) perchlorates
Authors:   Department of Pharmaceutical Chemistry, alkawaldeh Ahmad ,   College of Pharmacy, Jerash University, Jordan, Jafari Abdel Hadi ,   Department of Pharmaceutical Chemistry; College of Pharmacy, Jerash University, Jordan
Published: June 2022

As a consequence of a three-stage synthesis from terephthalic aldehyde, a series of 3,3 '- (1,4-phenylene) perchlorates including methyl, hydrogen, acetyl, bromio, methoxy and nitro groups (R = Br, H, Me). The matching formazans were reacted with formalin in dioxane in the presence of perchloric acid to produce tetrazin ium salts. Formazans were synthesized by reacting terephthalic aldehyde phenylhydrazone with ar ene diazonium tosylates in a DMF/pyridine combination. The use of ar ene diazonium tosylates greatly simplified the separation and purification of formazans. The p henylhydrazone was produced in aqueous dioxane using the usual approach from terephthalic aldehyde and phenylhydrazine/hydrochloric acid. Individual f ormazans and tetrazinium perchlorates were isolated and characterized by elemental analysis, IR, NMR, UV spectroscopy. The electrochemical reduction of tetrazinium perchlorates was investigated using cyclic voltammetry (CV). Thus, all salts in the cathode region have two one-electron reduction peaks, which are connected to the sequential production of a radical cation and a biradical. It was discovered that donor substituents (R: OMe, Me) in the aromatic ring at position 1 accelerate tetrazinium cation reduction, whereas acceptor substituents (R: NO2, COMe,) inhibit this process. On this premise, it was proposed that in the presence of donor substituents in the aromatic ring at position 1, the matching bis-verdazyl radicals should be easily generated. As a result, 3,3'- (1,4-phenylene) perchlorates are possible antecedents of symmetric biradical systems based on verdazyl radicals.
Memanfaatkan Peran Umpan Balik pada Kelas Online Matematika di Era Kenormalan Baru
Authors: Lisarani Varetha
Published: June 2022

In this era of The New Normal where students, teachers, and even parents are ‘forced’ to get accustomed to distance learning, we cannot simply overlook the importance of feedback on students’ work especially in mathematics teaching and learning, since feedback will provide information about the level of students' understanding of the material provided and also encourage them because their work is valued. This is a descriptive qualitative article about the overview of online mathematics classes and also how to utilize the role of feedback in them. The data in this article was enriched with the results of a questionnaire for 83 respondents from higher education in West Borneo. The results of the questionnaire revealed that 64.5% of respondents thought that online discussion groups were the most convenient platform to use in online learning, while video conference (90,3%) recorded the least. Regarding feedback, 53.8% of respondents chose corrective information on the work of the learner as the preferred form of feedback compared to the other two. At the end of this article, also suggested some ways for teachers to provide feedbacks based on the distance learning platform used in The New Normal Era.
Keywords: feedback, online class, new normal era
Generalisasi Ketaksamaan Sinus pada Segitiga
Authors: Hidayatin Nur , Murtinasari Frida
Published: June 2022

This study aims to find a generalization of the sine inequality of any triangles. This generalization is the general form of the sine inequality in a triangle when the angles given are not angles of the triangle, i.e. when the sum of the three angles is not equal to . The sine inequality that will be studied focuses on the inequalities of the sum and multiplication of sine in triangles. In the process, qualitative research methods are carried out in the form of literature review, namely studying the sum and the multiplication inequalities of sine in triangles which will then be developed and obtained new generalizations from the previous inequalities, namely generalizations of sine inequalities in triangles. These generalizations include generalizing the inequalities of the sum of sine in triangles and generalizing the inequalities of multiplication sine in triangles. To study this, it is necessary to first study the concepts of trigonometry, namely the definition of sine and cosine, the rules of sine and cosine; the relationship of the sine cosine to the sides of the triangle; the relationship of the radius of the circumcircle of the triangle to the sides and angles of the triangle; and arithmetic and geometric mean inequalities.The results of this study obtained the generalization of the sine inequality of any triangles.
Keywords: inequality, sine, triangle
SEGREGASI DAN FENOTIPE TANAMAN LABU MADU (Cucurbita moschata) KETURUNAN KEDUA (F2) DALAM RANGKA MENGEMBANGKAN VARIETAS UNGGUL
Authors: Wahyuni Endang Sri
Published: June 2022

Penelitian yang bertujuan untuk mengetahui peristiwa segregasi pada keturunan kedua (F2) labu madu dan bentuk fisik (fenotipe) yang terbentuk telah dilakukan sejak Juli sampai Nopember 2021 di Greenhouse Hidroponik Farm Perumahan Pondok Bedadung Indah Jember. Penelitian ini tanpa metode, hanya menanam biji dari buah F1 yang ditanam di tiga tempat yaitu instalasi NFT, polybag dan tanah. Pengamatan dilakukan dengan menimbang buah dan melihat bentuk fisik (fenotipe) buah labu F2 yang terbentuk. Hasil penelitian menunjukkan sifat yang tadinya terkumpul di F1 100% keturunan seragam. Setelah ditanam terjadi peristiwa segregasi dan menghasilkan 6 fenotipe.

Kata kunci: fenotipe F2, labu madu, segregasi.
Pengaruh Teknik Relaksasi Nafas Dalam terhadap Penurunan Nyeri Dismenore
Authors: Handayani Yuni , Putri Herlidian , Nurita Yusy Septyane
Published: June 2022

Dysmenorrhea is a pain experienced during menstruation which is quite severe which can interfere with daily activities. Dysmenorrhea can be experienced by women who have higher intrauterine pressure and have twice as many prostaglandin levels as women who do not experience dysmenorrhea. The incidence of dysmenorrhea that occurs in the world is quite large, where the average exceeds 50%, where women in each country are found to have dysmenorrhea. Meanwhile, in Indonesia alone, it is estimated that 55% of productive women with dysmenorrhea disrupt their activities. Desminorrhea pain can be treated with non-pharmacological therapy, one of which is deep breathing relaxation techniques. Where this technique can increase pulmonary ventilation, increase oxygenation in the blood, reduce pain intensity and suppress feelings of anxiety. The purpose of this study was to determine the effect of deep breathing relaxation techniques on reducing dysmenorrhea pain in adolescent girls at SMAN 5 Jember. This study uses a quasi-experimental approach with a one-group pre-test and post-test design approach. The population is 70 young women. The sample is 60 young women with sampling using simple random sampling technique. The results showed no pain 45.0%, mild pain 41.7%, moderate pain 13.3%. The analysis test used the Wilcoxon signed rank test with p-value = 0.000 < = 0.05. The conclusion in this study is that there is an effect of deep breathing relaxation techniques on reducing dysmenorrhea pain in adolescent girls. The results of this study are expected for young women at SMAN 5 Jember to be able to do deep breathing relaxation techniques when experiencing dysmenorrhea.
Relationship between the COVID-19 pandemic and currency exchange rates studied by means of the Dynamic Time Warping method
Authors: Landmesser-Rusek Joanna
Published: June 2022

The COVID-19 pandemic affected the entire global economic system, including currency exchange rates. The main objective of this study is to assess the similarity between time series of currency exchange rates before and during the COVID-19 crisis. In addition, the study aims to examine the relationship between the exchange rates of currencies and the COVID-19 time series in particular countries. The Dynamic Time Warping (DTW) method was applied to check if changes in the exchange rates were related to the spread of COVID-19, and if they were, to what extent it was so. The use of the DTW allows the calculation of the distance between analysed time series. In this study, it made it possible to group the analysed currencies according to their change relative to the pandemic dynamics. The study is based on data from the Stooq and Our World in Data websites. Data on the 17 studied currencies denominated in the New Zealand dollar came from the period between 1 January 2019 and 10 November 2021, and the COVID-19 data from the period between 1 March 2020 and 10 November 2021. The results demonstrate that exchange rates evolved differently in all the three analysed periods: the pre-pandemic period and the first and the second phase of the pandemic. The outbreak of the pandemic led to the concentration of most currencies around the US dollar. However, when the economies unfroze, a polarisation of the currency market occurred, with the world’s major currencies clustering either around the US dollar or the euro.
INFLUÊNCIA DOS LATICÍNIOS E DA SUPLEMENTAÇÃO PROTEICA NA MANIFESTAÇÃO DA ACNE
Authors: Vaz Diniz Andrea , Do Egypto Lívio e Vasconcelos , De Sousa Milena Nunes Alves
Published: June 2022

RESUMO: A acne vulgaris é classificada como a 8ª patologia mais comum em todo o mundo, com uma prevalência estimada de 9,4% globalmente. Ela afeta indivíduos da maioria das idades, no entanto, a prevalência mostra um pico significativo na adolescência. É considerada uma doença inflamatória crônica da unidade pilossebácea multifatorial, envolvendo fatores genéticos, desequilíbrio hormonal, aumento da produção de sebo, queratinização anormal e proliferação bacteriana. E, embora os fatores dietéticos tenham sido considerados sem importância, evidências apoiam o papel da nutrição como um fator predisponente na manifestação da acne. O presente estudo tem como objetivo realizar uma revisão integrativa explorando a associação entre a acne, a ingestão de laticínios (leite, iogurte, queijo), subgrupos de laticínios (gordura total, baixo teor de gordura, desnatado) e o uso de whey protein como suplementação proteica. Optou-se a realização de uma revisão integrativa de literatura que contemplasse a seguinte questão de pesquisa: “Qual a influência dos laticínios e da suplementação proteica em pacientes com diagnóstico de acne?”. A busca na literatura foi realizada na Medical Publisher (PUBMED), Science Direct e na Scientific Eletronic Library (SCIELO). Verificou-se que há evidências que demonstram a correlação do leite, seus derivados e das proteínas do leite “whey protein” na ocorrência da acne vulgar, sendo maior em indivíduos do gênero masculino. Os achados apontam para uma significativa correlação entre a influência dos laticínios e da suplementação proteica na manifestação da acne, mostrando uma maior incidência em indivíduos que fazem o uso de Whey Protein, consumo este popularizado na atualidade e disseminado na população mais jovem, que busca o ganho de massa corporal, desconhecendo os contras do uso desse tipo de susbstância.
Doutora Sara: um assistente virtual para marcação de consultas médicas
Authors: Silva André O. , Campos Leonardo B.
Published: June 2022

A ampla inserção dos aplicativos para trocas instantâneas de mensagens têm viabilizado a disseminação de assistente virtuais e chatbots. Na área de saúde, uma importante aplicação desses robôs ocorre no agendamento de consultas médicas onde, comumente, há necessidade de uma pessoa para executar essa tarefa. Dessa forma, Doutora Sara é um assistente virtual para agendamento de consultas médicas por meio do aplicativo WhatsApp, capaz de processar texto em linguagem natural. O assistente virtual utiliza aprendizagem de máquina e pode ser facilmente integrado a dispositivos de automação residencial, como o Alexa, e interagir com o paciente por meio de linguagem natural.
Análise e comparação de algoritmos de classificação para o diagnóstico de câncer de mama
Authors: Silva Jonas F. , Neves Tácito
Published: June 2022

O diagnóstico médico baseado em imagens apresenta diversos desafios computacionais, incluindo as fases de aquisição, de pré-processamento, segmentação e classificação das imagens. este trabalho parte da análise de um banco de dados de imagens de ressonância magnética de tumores de mama (mamografias) e implementação de algoritmos de aprendizado de máquina para a comparação do melhor modelo classificador para o diagnóstico do câncer de mama.
O Ensino de Informática através de um Projeto de Extensão aplicado ao Ensino Médio em uma escola da rede pública estadual para a inclusão digital
Authors: Aviz Wilamis Micael de Araujo
Published: June 2022

Neste artigo será apresentado um relato de experiência sobre um curso de extensão com aulas de informática voltado para discentes do Ensino Médio. O curso era composto por aulas teóricas e práticas com o fornecimento de material didático e tinha como objetivo promover a inclusão digital e estimular os alunos de uma escola da rede pública estadual, ao uso do computador com suas funcionalidades, bem como utilizar corretamente a internet. Os resultados demonstram que os alunos conseguiram aprender e aplicar satisfatoriamente os conceitos, o que implica em inclusão digital e início do processo de letramento digital.
Ferramentas de Busca para Crianças: revisão sistemática da literatura
Authors: Pontin Junior Laercio , Fülber Heleno , Veras Adonney Allan de Oliveira , Merlin Bruno
Published: June 2022

Este artigo descreve a revisão sistemática da literatura voltada para a definição de como as ferramentas de buscas Web são utilizadas hoje por alunos de series iniciais, bem como quais são suas características e falhas. Para tal, busca-se referencias nas bibliografias existentes, através de definição de palavras chaves e string de busca, que, alinhado com filtragem de resultados de periódicos com a técnica Snowboll, resulta na seleção de artigos relevantes ao tema. Esses possibilitam identificar que existem pesquisas voltadas para motores de buscas infantis, porém, notasse que ainda é um tema em aberto, se observado a sua complexidade.
Analysis of Hard Point Mechanical Behaviour Due to Variations of Potting Agent Volume on a Composite Sandwich Panel
Authors: MALI Mohamad , HUSSAIN Ahmad Kamil , HASSAN Mohd Bokhari , Mahmud Jamaluddin
Published: June 2022

Composite sandwich panels are widely used in lightweight structures, especially in aerospace, automotive, and marine industries. They are chosen mainly because of the superiority of their specific stiffness as compared to solid panels. Stingray, a solar car designed by the UiTM Eco-photon team, applied this technology for its lightweight property. However, the honeycomb sandwich constructions were susceptible to localized load. Thus, load attachment points using metal inserts, also known as ‘hard points’, were introduced. In this study, the behaviour of hard points based on three volume variations of the potting agent was investigated. ESA recommended static pull-out tests to be conducted on the sandwich panels composed of Nomex honeycomb core, two laminates of carbon fibres/epoxy composite as the face-sheets to determine the failure load of the hard points. A finite element simulation using ANSYS was also performed to determine the displacement of the inserts in presence of normal-to-plane load. The results include load versus extension curves obtained by both methods. Potting agents were found to elevate the stiffness and the strength of the inserts by some degree. Therefore, the application of these hard points on the solar car was found to be effective.
Implications of Land Use and Cover Changes on Upper River Rwizi Macro-Watershed Health in South Western Uganda
Authors: Nseka Denis , Opedes Hosea , Mugagga Frank , Ayesiga Patience , Semakula Henry , Wasswa Hannington , Ologe Daniel
Published: June 2022

The upper Rwizi river system in South Western Uganda has been severely degraded due to encroachment and unsustainable resource utilization. Little is, however, known about the link between the upper Rwizi macro-watershed health and land use/cover patterns from the spatiotemporal perspective. This study evaluated the relationship between spatiotemporal land use/ cover change and upper river Rwizi macro watershed health. Remotely sensed data was used to analyze the spatiotemporal land use and cover distribution for upper Rwizi macro watershed. The analysis was done using Landsat and Sentinel imagery datasets spanning 1990 to 2020 and 2016 to 2021 respectively. Field verification was undertaken to confirm the land use, cover types, and evaluate the implications of prevailing anthropogenic activities on the watershed health. The land use and cover characteristics in the upper Rwizi macro-watershed exhibits both highly spatial and temporal variations. By 1990, grassland as the dominant land use and cover type spanned 45% of the total study area followed by farmland at 30%. Forests, open water and settlements covered 12%, 10% and 3% respectively. Whereas grassland and forest cover has diminished drastically by 64% and 71% respectively, settlements and farmland have increased tremendously by 79% and 50% respectively between 1990 and 2020. The hillslope hydrological characteristics in the watershed are severely hampered due to increased human activities. It is, therefore, recommended that afforestation in the degraded areas be undertaken to restore the watershed health which could improve on hillslope hydrology.
Predictors of Compliance to Gluten-Free Diet in Children with Celiac Disease
Authors: Sayadi Mehrab , Niknam Ramin , Motazedian Nasrin , Dehghani Seyed Mohsen , Mashhadiagha Amirali
Published: June 2022

Background: Celiac disease (CD) is a common autoimmune disorder that presents intestinal and extra-intestinal symptoms. It is also associated with cardiovascular diseases and malignancies, and mortality risk. The only way to control the disease is to follow a strict gluten-free diet (GFD) for the rest of life. Objectives: This survey aimed to investigate GFD non-adherence and causes in the pediatric setting. Methods: In this study, 187 children aged between 2.5 to 14 years old with a confirmed diagnosis of CD at least for a year were studied using a questionnaire-based interview in a census study between 2018 to 2019 in a referral center in southern Iran. Results: About 40% of children adhered to a GFD poorly. This group significantly complained of more symptoms than the group with high adherence. Improper access was the most important cause of non-adherence to a GFD. The mean current weight and at the time of diagnosis as well as the mean current BMI and at the time of diagnosis in the non-adherent group were significantly lower than the adherent group. However, IgA anti-transglutaminase antibodies and histopathologic examination did not change remarkably. Furthermore, no significant relationship was found between following a GFD and age, age at the time of diagnosis, gender, and parental educational status. Conclusions: According to our results, inaccessibility, high costs, and lack of food labeling were the primary reasons for non-adherence to GDF. Therefore, to increase compliance, easy access to GFD with proper food labeling and suitable price should be implemented.
Certain proposals of the consul in Priština for improving the situation of the Serbian population (1889-1905)
Authors: Zarković Vesna
Published: June 2022

Thanks to the diplomatic work of Serbia and the engagement of its politicians, a consular convention was signed, on the basis of which consulates in the Ottoman Empire were opened. Among the open consulates, the consulate in Priština was of special importance for the Serbian people. Its consuls dealt almost exclusively with the difficult situation of the Serbian people, as evidenced by numerous reports sent to the Government in Belgrade. There were no other consulates in Priština and there was a great need for its work and protection of the large Serbian population north of the Šara Mountain. The position of Serbs in the area of the Priština consulate was hampered not only by the work of Turkish officials, but also by the anarchy and daily tyranny of Albanians, towards which the authorities were lenient. From its founding in 1889 until the liberation in 1912, ten consuls served in the consulate in Priština. It was not uncommon for clerks or dragomans to perform duties in the absence of consuls. Not only did they perform the service, but they also left very valuable written notes of that time, which occupy an important place in domestic historiography. The consuls of the Kingdom of Serbia in Priština witnessed various atrocities against the Serbian population by Albanians. The Turkish authorities acted negligently and did not show the will to take appropriate measures against the rioters. That is why, from the very opening of the consulate, various proposals could be heard, which were sent to the Government in Belgrade. Some of them referred to bringing the consuls closer to the Albanians, establishing contacts and cooperation with the leaders of Albanians, abolishing the consulate and finally arming the Serbian population. The consuls often insisted that the domestic and foreign press be engaged, because they thought that its actions would influence Porta and the sultan to prevent oppression of the Serbian population which, under the pressure, left their property and emigrated outside the Ottoman Empire.
Experiencia sensorial musical en la educación de estudiantes Sordos
Authors: Morales Acosta Gina Viviana , Verdugo Marquez Jorge
Published: June 2022

La educación musical para estudiantes sordos en Chile problematiza el quehacer profesional de docentes de Educación Especial para la vivencia y formación en Música con posiciones antagónicas entre determinismo estructural y transposición sensorial. De este modo, el trabajo se desarrolló por medio de la caracterización de las experiencias sensoriales, visuales y kinestésicas, con estudiantes de grado primero básico, en la asignatura de Música de una escuela especial de la Región Metropolitana de Santiago de Chile. Basado en un estudio de caso escolar único que incluyó la observación participativa en el aula durante la asignatura, recolección de datos visuales mediante entrevistas semiestructuradas. Participaron seis escolares usuarios de lengua de señas chilena (LSCh) con el apoyo de intérprete de LSCh. Los datos se transcribieron de vídeo a glosa del español escrito con el análisis de contenido de la experiencia sensorial. Los resultados a partir de la transposición sensorial y el determinismo estructural, reconocen la necesidad de una didáctica visual propia e instan a una deconstrucción del sonido como elemento hegemónico de la asignatura.
¿Tiene sentido el afinador? Un estudio sobre el impacto del temperamento igual en estudiantes de violín de nivel medio y superior
Authors: Brady Caldera Patrick Thomas , Archilla Segade Héctor
Published: June 2022

La entonación es una de las principales problemáticas con las que, generalmente, se encuentra el alumnado de violín. A través del presente trabajo, se busca determinar el impacto del Temperamento Igual en la capacidad de entonación que tiene el alumnado de violín de dos Conservatorios de Música de la Comunidad Autónoma de Extremadura. Para ello, se llevó a cabo un estudio no experimental cuantitativo, de tipo transversal exploratorio y descriptivo a través del que medir y recoger información relativa a la variable objeto de estudio “Capacidad de Entonación”. Los resultados señalan que la capacidad de entonación de los sujetos tiende a ajustarse al sistema de afinación pura o justa, si bien, en el ámbito del sistema temperado, dicha capacidad muestra un comportamiento similar. Se establecen también las tonalidades mejor afinadas en ambos sistemas y se destaca la naturaleza no temperada del instrumento.
Construcción de una escala perceptiva para la evaluación de la calidad de la voz cantada
Authors: Vila-Rovira Josep , Merzero Ainhoa , Laucirica Ana
Published: June 2022

En el marco de la educación vocal cantada el intercambio verbal entre docente y discente, se presenta como el recurso pedagógico más habitual. La selección de los términos de este intercambio, basados en la percepción del sonido de la voz, genera confusión por la dificultad de definición y de consenso de los mismos. En este trabajo se pretende consensuar algunos de estos conceptos y construir con ellos una escala de valoración de la calidad de la voz en el canto lírico. Para esto, y después de varios meses de discusión del grupo interno durante los que se elaboraron varias versiones de la escala, se construyó y administró un cuestionario de pertenencia y relevancia a 22 expertos. Finalmente, se organizó y celebró un grupo de discusión formado por siete encuestados más los componentes del grupo interno. La escala queda configurada con la selección y definición de 12 parámetros y la construcción de una escala visual perceptiva con adjetivos polares y graduada en diez tramos. La escala presentada se considera un instrumento válido para la valoración perceptiva de la voz cantada lírica.
CONDIÇÃO PERIODONTAL DE PACIENTES PORTADORES DE CANCER DE CABEÇA E PESCOÇO SUBMETIDOS À TERAPIA ANTINEOPLÁSICA
Authors: Dourado Martins Cerqueira Joana , Ticiane Barbosa de Lima Dantas Leila , Ticiane Barbosa de Lima Dantas Leila , Silva da Cruz Lorena , Souza Freitas Valéria , de Oliveira Campos Márcio , Guimarães Martins Ângela
Published: June 2022

Objetivo: Descrever a condição periodontal de pacientes com câncer de cabeça e pescoço atendidos na Universidade Estadual de Feira de Santana, Unidade de Alta Complexidade em Oncologia e no Centro de Especialidades Odontológicas, em Feira de Santana, no período de 2018 a 2019. Materiais e métodos: Estudo de corte transversal de caráter descritivo, através da coleta de informações a respeito das condições sociodemográficas, hábitos de vida e de saúde geral, além de exame clínico dos pacientes estudados. Os parâmetros para diagnóstico periodontal foram profundidade de sondagem, nível de inserção clínica, índice de placa visível, índice de sangramento gengival e biótipo periodontal. Os dados foram submetidos à análise descritiva utilizando o programa SPSS versão 26. As variáveis foram analisadas através das frequências absoluta e relativa e por medidas de tendência central. Resultados: A maioria dos pacientes estudados era do sexo masculino (82,4%), entre 60 e 69 anos (35,3%), faioderma (47,1%), com baixa escolaridade (41,2%) e com tumor em faringe (38,2%). 90,3% dos casos eram carcinoma de células escamosas. A terapêutica mais utilizada foi radioterapia (96,9%). 85,3% apresentaram periodontite moderada ou grave. 92,6% dos casos registrados apresentavam periodonto espesso. As medianas de índice de placa e sangramento gengival foram de 55% e 16,3% dos sítios sondados, respectivamente. 67,7% passaram por tratamento odontológico previamente à terapia antineoplásica. Conclusão: A presença de doença periodontal foi constatada na maior parte dos pacientes acometidos por câncer de cabeça e pescoço, em sua maioria nos graus moderada e grave.
PANORAMA ATUAL DA PREVALÊNCIA DO CÂNCER DE BOCA NO ESTADO DA BAHIA: DE 2015 A 2020
Authors: Santos Oliveira Stefani , Beatriz Sales da Silva Santos  , Igor Ferreira Borba de Almeida  , Aline de Matos Vilas Boas  , Deybson Borba de Almeida
Published: June 2022

Epidemiologicamente, o câncer de boca tem alta taxa de recorrência no Brasil, acometendo as estruturas como lábio, assoalho bucal, palato duro e principalmente a língua, este possui a 12° posição entre as mulheres e 5° posição entre os homens como tipo mais incidente. Tendo em vista a relevância da temática e necessidade de atualização do panorama da prevalência do câncer de boca no Brasil, o objetivo deste estudo descritivo é abordar e descrever o panorama atual da prevalência do câncer de boca no estado da Bahia, no período de 2015 a 2020, com ênfase na taxa de mortalidade entre homens e mulheres. Trata-se de um estudo quantitativo-descritivo desenvolvido por meio dos dados fornecidos pelo Ministério da Saúde do Brasil. A Bahia é o terceiro estado do Nordeste com mais casos e óbitos pela doença. Os homens acima dos 50 anos de idade são os mais acometidos. Os resultados deste estudo demonstram que a Bahia é uma região importante de acometimento do câncer de boca e portanto, devem ser intensificadas as estratégias de detecção e tratamentos precoces dessa doença.Palavras-chave: Câncer da boca. Neoplasias bucais. Estudos de prevalência.
ANOMALIAS DENTÁRIAS: ESTUDO LONGITUDINAL LIGADO A HEREDITARIEDADE
Authors: Magalhães Amanda , Carneiro Guimarães Gessica Taiany , De Jesus Santos Oliveira Noíny , De Oliveira Lopes Azevêdo Samile , Polyana Nunes Goes Polyana
Published: June 2022

As falhas que ocorrem durante o processo de odontogênese ocasionam alterações de desenvolvimento que são capazes de resultar em anomalias dentárias. A agenesia dentária tanto sindrômica quanto não‐sindrômica, esporádica ou familial, trata-se de uma anomalia de desenvolvimento de caráter quantitativo, classificada em anodontia total ou parcial, sendo subdividida em hipodontia e oligodontia. Sua etiologia principal é o fator genético, manifestada através da associação com mutações em genes importantes para o desenvolvimento embrionário e pode ser observada em grupos familiares. Objetivo: Relatar o caso de indivíduos da mesma família com oligodontia, fazer correlação entre essa anomalia e a hereditariedade. Relato de caso: Paciente do sexo masculino 34 anos compareceu a Clínica Escola de Odontologia da UNIFTC acompanhado dos dois filhos, onde foram submetidos à exame clinico e radiográfico, sendo observado ausências dentarias no genitor e na sua prole, além do atraso na cronologia de erupção no filho mais novo. Considerações finais: O estudo concluiu que os três indivíduos apresentaram ausências de mais de seis unidades dentárias, sendo diagnosticados com oligodontia não sindrômica com base em exames clínicos, e confirmados por exames radiográficos.
TRATAMENTO ENDODÔNTICO EM DENTES COM REABSORÇÃO RADICULAR APICAL EXTERNA: RELATO DE CASO
Authors: Figueiredo Carvalho Ismênia , Da Silva Ribeiro Matheus , Bomfim Bendocchi Alves Giovanna , Dourado Martins Cerqueira Joana
Published: June 2022

Introdução: A reabsorção radicular consiste na perda de estrutura dentária nos  diferentes terços da raiz. Objetivo: Relatar um caso clínico de tratamento endodôntico  em dentes anteriores com reabsorção radicular apical externa. Material e método: Trata-se de um relato de caso de uma paciente do sexo feminino, 53 anos, compareceu à clínica-escola de Odontologia da  UNEF queixando-se de dor em região do dente 13. Na anamnese, a paciente relatou  ter realizado tratamento ortodôntico há cinco anos. Com base na avaliação clínica e  nos exames de imagem, identificou-se a presença de Reabsorção Radicular Apical  Externa (RRAE) nos dentes anteriores, e devido a restaurações insatisfatórias já  existentes, foi possível diagnosticar a unidade 13 como Necrose Pulpar associada à  Periodontite Apical Crônica, e a unidade 23, como Pulpite Irreversível Sintomática,  sendo proposto o tratamento endodôntico para ambas unidades. Os demais dentes  não apresentavam comprometimento pulpar. Resultados: Após 18 meses, observou se a cicatrização da lesão periodontal na unidade 13, e que as demais unidades  apresentavam-se com boa resposta ao teste de vitalidade pulpar, com exceção da  unidade 22, que já possuía uma restauração insatisfatória, e apresentou uma resposta  de baixa intensidade e com declínio lento, característico de uma pulpite irreversível  assintomática em transição para necrose pulpar, na qual foi proposto a pulpectomia  como tratamento. Conclusão: No acompanhamento de 17 meses, os dentes anteriores  apresentavam-se livres de sinais e sintomas, sem progressão da reabsorção, e  radiograficamente, as superfícies radiculares encontravam-se íntegras, havendo o  reparo da lesão na unidade 13.

PALAVRAS-CHAVE: Reabsorção da raiz; Endodontia; Diagnóstico.
Visualizing molecules of functional human profilin
Authors: Pimm Morgan L , Liu Xinbei , Tuli Farzana , Heritz Jennifer , Lojko Ashley , Henty-Ridilla Jessica L
Published: June 2022

Profilin-1 (PFN1) is a cytoskeletal protein that regulates the dynamics of actin and microtubule assembly. Thus, PFN1 is essential for the normal division, motility, and morphology of cells. Unfortunately, conventional fusion and direct labeling strategies compromise different facets of PFN1 function. As a consequence, the only methods used to determine known PFN1 functions have been indirect and often deduced in cell-free biochemical assays. We engineered and characterized two genetically encoded versions of tagged PFN1 that behave identical to each other and the tag-free protein. In biochemical assays purified proteins bind to phosphoinositide lipids, catalyze nucleotide exchange on actin monomers, stimulate formin-mediated actin filament assembly, and bound tubulin dimers (kD = 1.89 µM) to impact microtubule dynamics. In PFN1-deficient mammalian cells, Halo-PFN1 or mApple-PFN1 (mAp-PEN1) restored morphological and cytoskeletal functions. Titrations of self-labeling Halo-ligands were used to visualize molecules of PFN1. This approach combined with specific function-disrupting point-mutants (Y6D and R88E) revealed PFN1 bound to microtubules in live cells. Cells expressing the ALS-associated G118V disease variant did not associate with actin filaments or microtubules. Thus, these tagged PFN1s are reliable tools for studying the dynamic interactions of PFN1 with actin or microtubules in vitro as well as in important cell processes or disease-states.
Association between fibrinogen/albumin ratio and severity of coronary artery calcification in patients with chronic kidney disease: a retrospective study
Authors: Zhu Yuyu , Tao Shuman , Zhang Danfeng , Xiao Jianping , Wang Xuerong , Yuan Liang , Pan Haifeng , Wang Deguang
Published: June 2022

Aim

Previous studies have shown that the fibrinogen to albumin ratio (FAR) is closely related to the severity and prognosis of coronary atherosclerosis. In this study, we sought to evaluate the association between FAR and the degree of coronary artery calcification (CAC) in patients with chronic kidney disease (CKD).

Methods

In this retrospective study, 218 patients with CKD were stratified into low, medium and high FAR groups according to the tertiles of the FAR values. The CAC scores, clinical information and laboratory test results of the three FAR groups were compared. To explore the relationship between FAR and CAC we conducted binary logistic regression and correlation analyses.

Results

In the low FAR group, the CAC scores were significantly lower than those in the medium and high FAR groups (P  <  0.001). There was a significant correlation between the FAR and CAC scores (r = 0.510,P  <  0.001). The FAR was an independent predictor of CAC (OR = 1.106, 95% CI [1.004–1.218],P = 0.042).

Conclusion

In patients with CKD, the FAR can be considered as an effective predictor of CAC.
Características generales y evolución según el índice de masa corporal en pacientes con Infarto Agudo de Miocardio en Argentina. (Registro ARGEN-IAM-ST)
Authors: Frontera Esteban , Pulmari Camilo , Castillo Costa Yanina , D´Imperio Heraldo , Charask Adrián , Plogger Claudio , Zoni Rodrigo , Quiroga Walter , Gagliardi Juan
Published: June 2022

Background: Body mass index (BMI) in overweight and obesity ranges is an increasingly frequent cardiovascular risk factor. Its prognostic value is debatable in the setting of acute myocardial infarction (AMI). Objectives: The aim of this study is to acknowledge the clinical characteristics, reperfusion strategies outcome of the cases included in the ARGEN-IAM ST according to BMI. Methods: We conducted a prospective study of the cases included in the registry. Patients with incomplete anthropometric data were excluded. Three groups were defined: healthy BMI < 25 kg/m2 (G1), overweight: BMI between 25 and 29.9 kg/m2 (G2) and obesity: BMI ≥30 kg/m2 (G3). Results: 2925 cases were included. Patients in G3 were younger (G1: 63±12, G2: 61±11, G3: 60±11 years, p=0.0001), and had higher incidence of diabetes (G1: 11%, G2: 22%, G3: 28%; p=0.0001) and dyslipidemia (G1: 35%, G2: 40%, G3: 43%; p=0.01). There were no differences in door-to-balloon time (median 104 minutes in G1, 110 in G2 and 110 in G3, p=0.27), two-vessel disease or greater (G1 38%, G2 34.5% and G3 37%; p=0.26) and in-hospital mortality (G1 9.7%, G2 7.5% and G3 8.4%; p=0.22). In multivariate analysis Killip class other than A (OR: 20.1; 95% CI 13.1-30.8; p<0.0001), age (OR: 1.7; 95% CI 1.2-2.5; p<0.0001) and two-vessel disease or greater (OR: 1.5; 95% CI 1.03-2.1; p<0.0001) were independent predictors of in-hospital mortality. Conclusions: Overweight and obese patients were younger, with higher incidence of diabetes and dyslipidemia. There were no significant differences in the type of presentation, treatment and complications. In multivariate analysis, overweight and obesity were not predictors of mortality.
Predictors of Left Ventricular Dysfunction after Percutaneous Primary Coronary Intervention in Acute Anterior Myocardial Infarction
Authors: Darwesh Marwa Abd El-Monsef , Ibrahim Ibtsam Khairat , Allah Timoor Mustafa Abd , Salama Mai Mohamed
Published: June 2022

Background: Primary percutaneous coronary intervention (PCI) has revolutionized the outcome and management of acute myocardial infarction. However, the occurrence of left ventricular dysfunction remains relatively common event following acute myocardial infarction and in associated with an adverse prognosis in these patients. this work aimed to investigate to the left ventricular dysfunction predictors following PCI for anterior myocardial infarction (AMI) using different parameters: Tissue Doppler imaging (TDI), Biomarkers (Troponin, CK-MB) and Echocardiography

Methods: This research was conducted prospectively on 50 patients aged from 40 to 70 years old, presenting by first anterior myocardial infarction and treated with PCI. All cases were subjected to full history, full clinical examination, laboratory investigations, resting 12 leads electrocardiography, two dimensions echocardiography and tissue doppler imaging.

Results: Highly statistically significant between EF baseline with EF on discharge and EF on discharge with after 3 months p-value was <0.001. Pre balloon dilatation, S wave of tissue Doppler imaging on discharge and S wave tissue Doppler imaging after 3 months were predictors for left ventricular systolic function.

Conclusions: Persistent LV dysfunction following successful primary PCI is infrequent and is related to poor clinical outcomes at 3 months clinical follow-up. Tissue Doppler on discharge and after three months after myocardial infarction are independent predictors of LV dysfunction after anterior STEMI and can be used to predict occurrence of LV remodelling after 6 months.
Response of NPK, Zinc and Boron Fertilization on Physico-chemical Properties of Soil under summer Green Gram (Vigna radiate L.) Cultivation in an Inceptisol of Prayagraj, (Uttar Pradesh)
Authors: Ravindra Jadhav , Swaroop Narendra , Thomas Tarence
Published: June 2022

The study pertaining to the present topic under field investigation is entitled "Response of N, P, K, Zinc and Boron fertilization on Soil Health, Growth and Yield Attributes of Summer Green gram (Vigna radiata L.) in an Inceptisol of Prayagraj, Uttar Pradesh" for two consecutive years, beginning from the summer seasons of the years 2021 and 2022 at Research Farm, Department of Soil Science and Agricultural Chemistry. Before conducting research operations, an excavated soil sample from the experimental site revealed that the land topography ranged from nearly level to 1-3% slope, the soil is of sandy loam texture with near neutral in reaction (7.62), the electrical conductivity was non-saline (0.23 dS m-1) in nature, the low organic carbon content (0.29%), the low to medium available N (146.62 kg ha-1), available P (13.78 kg ha-1) and available K (207.15kg ha-1). The best results were seen with treatment (T11), which was made up of RDF (20:40:20 NPK kg ha-1) + Zinc@6 kg ha-1+ Boron@3 kg ha-1. This treatment used NPK and different micronutrient (Zinc and Boron) levels at the same time. regard to physical soil parameters, the cumulative mean value for bulk density (1.27 Mg m-3), percent pore space (47.74%), particle density (2.67 Mg m-3) and percent maximum water holding capacity (43.68%) were increased and chemical soil parameters with a cumulative mean of slightly saline soil pH (7.81), average electrical conductivity (0.37 dS m-1), medium available N (275.93 kg ha-1), medium available P in T2 (21.07 kg ha-1) due to the antagonistic effect of zinc on Phosphorous, medium available K (230.38 kg ha-1), high available Zn (0.623 mg kg-1), and high available B (0.616 mg kg-1) were labeled in comparison to other NPK and micronutrients levels treatments.
Cerebral Autoregulation and Cardiovascular Physiology Dysfunction in Traumatic Brain Injury Cases: A Brief Review
Authors: Yasin Ahmad , Yushatia Nabigha , Islam Itzar Chaidir , Agrabudi Andi Ilman , Qalbi Asilah Nurul , Widjaja Widiana
Published: June 2022

Introduction: Traumatic brain injury (TBI) is one of the leading causes of death and disability in the early years of life. Post-TBI physiological alterations vary across adult and pediatric patients and severity. This disease affects the quality of life of most people. Acute hemiparesis can cause cognitive impairments. It may also impact mood, memory, and decision-making. Furthermore, parasympathetic dysfunction and sympathetic activation appear to contribute to cardiac injury via modulation of the myocardial inflammatory response via acetylcholine receptors.

Purpose: This review aims to explain the neuronal response and cardiac dysfunction after traumatic brain injury cases.

Methods: The review used Pubmed and Google Scholar to search for articles on traumatic brain injury, neuronal response, and cardiac biomarkers. The articles were chosen for their language, publishing, content, exposure, and outcome. The main reference is obtained from up to 79 articles that meet the inclusion requirements.

Results: TBI can cause localized brain injury or diffuse brain injury from physical trauma such as diffuse axonal injury or brain edema. Repeated concussions raise the likelihood of chronic neurological, cognitive, and behavioral issues. Stress-induced catecholamine surges and inflammatory mediator production in response to trauma may also endanger cardiac disturbances. ECG changes in patients with severe traumatic brain injury are associated with cardiac dysfunction. Cardiac enzymes can be used as a diagnostic tool and indicate the patient's prognosis.

Conclusion: Cerebral autoregulation and cardiac physiological responses have a synergistic relationship in maintaining tissue homeostasis in patients with traumatic brain injury. Patients with TBI may experience cardiac dysfunction as a result of the body’s exaggerated systemic response to brain injury.
Prevention of Adjuvant Treatment Induced Cardiotoxicity in Egyptian Breast Cancer (BC) Patients: A Randomized Prospective Study
Authors: Adel Azza M. , Gado Niven M. , Ragab Dina , Ali Yasmin Abdelrazek , Samir Ahmed , Ibrahim Hagar
Published: June 2022

Background: Adjuvant Anthracyclines Chemotherapy (ANTC) and trastuzumab have been documented to prolong survival in patients with breast cancer (BC). However, these drugs are also well known to induce left ventricular systolic dysfunction (LVSD). Multiple studies have shown that angiotensin converting enzyme inhibitors (ACEIs) and beta blockers (BBs) can prevent LVSD among women with BC.

Objectives: We aimed to prospectively evaluate the efficacy of enalapril (ACEI) and carvedilol (BB) in preventing the ANTC ± trastuzumab induced LVSD, in patients with non-metastatic BC.

Patients and Methods: We randomized 126 patients with non-metastatic (M0) BC, who were scheduled to be treated with ANTC ± trastuzumab into the intervention group (group 1; n = 63), which received enalapril and carvedilol or the control group (group 2; n = 63), which did not receive enalapril or carvedilol. To evaluate left ventricular (LV) systolic and diastolic functions the conventional echocardiography (ECHO) and cardiac magnetic resonance imaging (CMR) were performed at baseline, after 3 therapy cycles, and at 1-year follow-up. The secondary endpoint was designed to detect the incidence of a decrease in left ventricular ejection fraction (LVEF) ≥ 10%, heart failure (HF), LVSD (defined as LVEF<45%) or deterioration in LV diastolic function.

Results: In the intervention group, 58 patients had 3 cycles ANTC, 6 patients received 6 cycles ANTC, and 12 patients received trastuzumab. In the control group, 47 patients had 3 cycles ANTC, 16 patients were given 6 cycles ANTC and 18 patients received trastuzumab (as per the guidelines issued by breast clinic in the department of clinical oncology, faculty of medicine, Ain Shams University) for adjuvant and neoadjuvant chemotherapy in early breast cancer).

After 3 ANTC cycles, LVEF did not change in the intervention group, but decreased by M-mode in the control group (p-value: 0.03), which was associated with statistically significant deterioration of LV diastolic function. At 1 year follow-up, while no change was observed in LVEF in group 1, there was a decrease in LVEF by CMR in group 2 (65.78% at baseline, 61.48% at 1 year; p-value: 0.04 8).

Conclusion: Combined prophylaxis with enalapril and carvedilol may prevent LVSD in patients with non-metastatic BC treated with anthracycline-containing chemotherapy ± trastuzumab. However, the clinical relevance of this strategy should be confirmed in the future, large-scale randomized studies.
DISPUTAS E LEGISLAÇÕES NO CARNAVAL DO RECIFE (1955-1964)
Authors: Santos Rosana Maria dos
Published: June 2022

Este artigo tem por objetivo analisar e problematizar a história do carnaval do Recife entre 1955 e 1964. Nessa época, organizar o reinado de Momo tornou-se uma prioridade política, pois os administradores julgavam necessário criar políticas públicas capazes de solucionar uma questão que há décadas era destaque nos periódicos da cidade: salvar o carnaval do Recife de uma “decadência”. Logo após o fim dos festejos momescos de 1955, a Prefeitura da cidade tenta tomar para si a organização da festa, oficializando o carnaval da cidade, que passou a ser organizado pelo Departamento de Documentação e Cultura (DDC). Nesta pesquisa, analisamos as disputas políticas, sociais e as proibições às práticas consideradas subversivas, que eram comuns nos dias de Momo.
UMA LEITURA DO FEMININO NA ODISSEIA: o caso de Penélope, e o perfil da mulher helênica pré-socrática
Authors: Machado Alexandre Bartilotti , Barreiros Marcia Maria da Silva
Published: June 2022

O presente artigo tem por objetivo propor uma leitura da participação social do gênero feminino na épica homérica. Para esse estudo, especificamente, trabalhamos com a figura de Penélope e sua relação dialética com o gênero masculino através da figura de Ulisses. Em primeira instância, analisamos como Penélope se constitui enquanto ser imprescindível à areté heroica e, mais amplamente, como mulher da Grécia arcaica, responsável pela manutenção do oikos e das tradições. Após isso, analisamos a construção do gênero masculino dentro de um recorte aristocrático, por meio da figura de Ulisses. Posto isso, far-se-á uma análise do feminino, portanto, com o intuito de evidenciá-lo em plena prática de seus saberes, fazeres e poderes nos espaços sociais.