bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplemental data figure 1 from A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity
Authors: Mysore Veena S. , Szablowski Jerzy , Dervan Peter B. , Frost Patrick J.
Published: April 2023

This is supplemental data demonstrating the uptake of FITC-labeled HIF-PA into xenograft tumor cells.
Supplementary Methods, Figure Legends from Identification of mTORC2 as a Necessary Component of HRG/ErbB2-Dependent Cellular Transformation
Authors: Lin Miao-chong J. , Rojas Katherine S. , Cerione Richard A. , Wilson Kristin F.
Published: April 2023

PDF file - 83K
Supplementary Figure 5 from Identification of mTORC2 as a Necessary Component of HRG/ErbB2-Dependent Cellular Transformation
Authors: Lin Miao-chong J. , Rojas Katherine S. , Cerione Richard A. , Wilson Kristin F.
Published: April 2023

PDF file - 62K, Ectopically-expressed components of both mTORC1 and mTORC2 in HEK 293T cells can interact with TSC2 as well as mTOR. HEK 293T cells were transfected with either Myc-Raptor or Myc-Rictor. Cells were then lysed in lysis buffer containing 0.3% CHAPS and subjected to immunoprecipitation using anti-Myc antibody to precipitate Raptor or Rictor. The precipitated samples were subjected to Western blotting probing for mTOR, TSC2, and Myc.
Supplementary Figure 3 from Identification of mTORC2 as a Necessary Component of HRG/ErbB2-Dependent Cellular Transformation
Authors: Lin Miao-chong J. , Rojas Katherine S. , Cerione Richard A. , Wilson Kristin F.
Published: April 2023

PDF file - 128K, Two mechanistically-distinct mTOR inhibitors, rapamycin and INK-128, show differential abilities to inhibit signaling components upstream of mTORC1. SKBR3 cells were serum-starved for 40-48 h. Rapamycin (50 nM) or INK (50 nM) was added to the cells for 30 minutes prior to the additional treatment of cells with or without 1 nM HRG for 30 min. Cells were then harvested, lysed, and then lysates were analyzed by Western blotting for relative levels of phospho-mTOR (S2448), phospho-TSC2 (T1462), phopsho-AKT (T308), phospho-AKT (S473) and the corresponding total proteins.
PCR Primer Sequences from PCBP1/HNRNP E1 Protects Chromosomal Integrity by Translational Regulation of CDC27
Authors: Link Laura A. , Howley Breege V. , Hussey George S. , Howe Philip H.
Published: April 2023

S2. Nucleotide sequences for primers used in PCR reactions.
Supplementary Figure S6 from Sulfiredoxin Promotes Colorectal Cancer Cell Invasion and Metastasis through a Novel Mechanism of Enhancing EGFR Signaling
Authors: Jiang Hong , Wu Lisha , Chen Jing , Mishra Murli , Chawsheen Hedy A. , Zhu Haining , Wei Qiou
Published: April 2023

Identification of acetylated lysine residues by LC-ESI-MS/MS. (A) Immunoprecipitated EGFR from HT29 cells and HCT116 ShSrx cells were stained with coomassie brilliant blue. EGFR bands were extracted form MS analysis. (B) Representative spectrum of K203 acetylation identified by MS.
Table S7 from Metabolic Profiling in Formalin-Fixed and Paraffin-Embedded Prostate Cancer Tissues
Authors: Cacciatore Stefano , Zadra Giorgia , Bango Clyde , Penney Kathryn L. , Tyekucheva Svitlana , Yanes Oscar , Loda Massimo
Published: April 2023

Metabolite statistical analysis of the differences between LNCaP and LNCaP-Abl.
Table S14 from Metabolic Profiling in Formalin-Fixed and Paraffin-Embedded Prostate Cancer Tissues
Authors: Cacciatore Stefano , Zadra Giorgia , Bango Clyde , Penney Kathryn L. , Tyekucheva Svitlana , Yanes Oscar , Loda Massimo
Published: April 2023

Histological analysis of the FFPE sections of the validation set after methanol extraction.
Supplementary Figure Legends from PAI-1 Leads to G1-Phase Cell-Cycle Progression through Cyclin D3/cdk4/6 Upregulation
Authors: Giacoia Evan Gomes , Miyake Makito , Lawton Adrienne , Goodison Steve , Rosser Charles J.
Published: April 2023

PDF file - 73KB
Supplementary Figures S1-S5 from AKT-Induced Tamoxifen Resistance Is Overturned by RRM2 Inhibition
Authors: Shah Khyati N. , Mehta Kshama R. , Peterson David , Evangelista Marie , Livesey John C. , Faridi Jesika S.
Published: April 2023

PDF file - 917 KB, Legends for Supplementary Figures: Supplementary Fig. S1: AKT1 and AKT3 are highly expressed in patient breast cancer tumors and AKT3 expression correlates with recurrence and ER negative status. Box and whisker plot of AKT isoforms expression in (A) normal versus breast carcinoma specimens, (B) tumors of different grade, and tumors with respect to (C) recurrence and (D) estrogen receptor status using Oncomine TCGA datasets. Supplementary Fig. S2: Tamoxifen induces cell proliferation in breast cancer cells with high levels of Akt. Venn diagrams show overlaps of differentially expressed genes (A) C, E and T treated parental MCF-7 versus Akt3 cells (MC:AC, ME:AE, and MT:AT). (B) C versus E treated parental MCF-7 (MC:ME) and T treated parental MCF-7 versus Akt overexpressing MCF-7 cells (MT:AT). Ingenuity pathway analysis was used to generate the network of differentially expressed genes (C) upon estrogen versus control treatment in parental MCF-7 cells and (D) upon tamoxifen treatment in parental MCF-7 versus Akt3 overexpressing cells. Genes shown in red are up- regulated, genes shown in green are down-regulated and central nodes are estradiol (C) and NFkB (D). Supplementary Fig. S3: Differential gene expression variations in breast cancer cells RT-qPCR confirmation analysis of (A) up-regulated and (B) down-regulated genes was examined in cells upon Akt overexpression. Fold change is shown relative to control treated parental MCF-7 cells. Supplementary Fig. S4: Altered gene expression in normal versus breast carcinoma specimens using the Oncomine database. Altered expression of (A) up-regulated and (B) down-regulated genes is shown. Fold changes (FC) of breast carcinoma were calculated relative to normal breast tissue and comparisons between groups were made by two-sample t-tests. Supplementary Fig. S5: (A) Knockdown efficiencies of siRRM2#1 and siRRM2#2 as compared to non-targeting control (NT C). (B) Western blots showing efficient knockdown of RRM2 protein in six breast cancer cell line. (C) Cellular proliferation between siRNA treatments were compared relative to NT C. (D) Knockdown efficiencies of siRRM2 remained high over seven days as validated by RT-qPCR. (E) Images were captured by phase contrast microscopy using a 4? objective at 20 h after removal of inserts for siRRM2 transfected and non-targeting control. siRRM2 significantly inhibited motility in Akt1 and Akt3 overexpressing MCF7 cells and MDA-MB-231 cells indicated by arrows.
Supplementary Table 3 from A Genome-Wide Loss-of-Function Screen Identifies SLC26A2 as a Novel Mediator of TRAIL Resistance
Authors: Dimberg Lina Y. , Towers Christina G. , Behbakht Kian , Hotz Taylor J. , Kim Jihye , Fosmire Susan , Porter Christopher C. , Tan Aik-Choon , Thorburn Andrew , Ford Heide L.
Published: April 2023

Supplementary Table 3: GSEA analysis for upregulated (enriched) pathways in TRAIL treated MDA-231 TRAILR vs. SENS
Supplemental Table 1 from A Genome-Wide Loss-of-Function Screen Identifies SLC26A2 as a Novel Mediator of TRAIL Resistance
Authors: Dimberg Lina Y. , Towers Christina G. , Behbakht Kian , Hotz Taylor J. , Kim Jihye , Fosmire Susan , Porter Christopher C. , Tan Aik-Choon , Thorburn Andrew , Ford Heide L.
Published: April 2023

Supplemental Table 1: Significantly enriched pathways from GIANT analysis
Supplementary Figure 1 from SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide
Authors: Ensign Shannon P. Fortin , Roos Alison , Mathews Ian T. , Dhruv Harshil D. , Tuncali Serdar , Sarkaria Jann N. , Symons Marc H. , Loftus Joseph C. , Berens Michael E. , Tran Nhan L.
Published: April 2023

Supplementary Figure 1. Depletion of SGEF expression does not alter glioma cell proliferation or cell cycle.
Supplementary Figures 1 - 8 from The Adherens Junction Protein Afadin Is an AKT Substrate that Regulates Breast Cancer Cell Migration
Authors: Elloul Sivan , Kedrin Dmitriy , Knoblauch Nicholas W. , Beck Andrew H. , Toker Alex
Published: April 2023

PDF file - 1702K, Supplementary figures S1 - S8 Fig. S1 shows phosphorylation of Afadin in mediated by PI 3-kinase and Akt Fig. S2 shows localization of Afadin in response to IGF-1 stimulation Fig. S3 shows localization of Afadin mediated by PI 3-kinase and Akt Fig. S4 shows single channel images of wild type Afadin and Afadin mutants Fig. S5 shows localization of Afadin in breast cancer cell lines, and effect of Afadin silencing on breast cancer cell migration. Fig. S6 shows nuclear localization of Afadin and Afadin mutants in T47D cells Fig. S7 shows nuclear localization of Afadin and Afadin mutants in MCF10A cells Fig. S8 shows schematic representation of the quantification of Afadin nuclear localization.
Supplementary Figure Legends from A Monotonic and Prognostic Genomic Signature from Fibroblasts for Colorectal Cancer Initiation, Progression, and Metastasis
Authors: Berdiel-Acer Mireia , Cuadras Daniel , Díaz-Maroto Natalia Guillén , Sanjuan Xavier , Serrano Teresa , Berenguer Antoni , Moreno Victor , Gonçalves-Ribeiro Samuel , Salazar Ramon , Villanueva Alberto , Molleví David G.
Published: April 2023

PDF file - 74KB
RT-PCR analysis of EGFR extracellular domain mutations in the remaining COG NB RNA from A Novel EGFR Extracellular Domain Mutant, EGFRΔ768, Possesses Distinct Biological and Biochemical Properties in Neuroblastoma
Authors: Keller James , Nimnual Anjaruwee S. , Varghese Mathew S. , VanHeyst Kristen A. , Hayman Michael J. , Chan Edward L.
Published: April 2023

S2. All PCR products were confirmed to be either EGFRÎ"768 or EGFRvIII by bidirectional sequencing. Black arrows indicated EGFRÎ"768 and white arrows pointed to EGFRvIII. H2O was negative control.
Supplementary Figure 4 from A Monotonic and Prognostic Genomic Signature from Fibroblasts for Colorectal Cancer Initiation, Progression, and Metastasis
Authors: Berdiel-Acer Mireia , Cuadras Daniel , Díaz-Maroto Natalia Guillén , Sanjuan Xavier , Serrano Teresa , Berenguer Antoni , Moreno Victor , Gonçalves-Ribeiro Samuel , Salazar Ramon , Villanueva Alberto , Molleví David G.
Published: April 2023

PDF file - 168KB, A: Scatterplots of RMA normalised expression values for 25 genes selected after refining the PAM process. Green dots for NCF, yellow dots for CAF-PT and red dots for CAF-LM. B: RT-PCR validation of selected genes in nine NCF, nine CAF-PT and nine CAF-LM, normalising with housekeeping genes ACTB and PMM1.
Phosphoreceptor tyrosine kinase and phosphokinase array analyses of the EGFRvIII in the transiently transfected IMR32 cells from A Novel EGFR Extracellular Domain Mutant, EGFRΔ768, Possesses Distinct Biological and Biochemical Properties in Neuroblastoma
Authors: Keller James , Nimnual Anjaruwee S. , Varghese Mathew S. , VanHeyst Kristen A. , Hayman Michael J. , Chan Edward L.
Published: April 2023

S7. EGFRvIII activation resulted in phosphorylation of EphA10, RYK and ALK in these cells. Noted the strong EGFRvIII phosphorylation signal detected by the array.
Supplemental Figures from DNA Polymerase Beta Germline Variant Confers Cellular Response to Cisplatin Therapy
Authors: Nemec Antonia A. , Abriola Laura , Merkel Jane S. , de Stanchina Elisa , DeVeaux Michelle , Zelterman Daniel , Glazer Peter M. , Sweasy Joann B.
Published: April 2023

S1. Dose-response curve of MCF7 cells. S2. Western blotting analysis of Pol beta in cell lines. S3. Pol beta and XPA interact in vitro. S4. The effect of E295K Pol beta expression on survival following cisplatin treatment. Table S1. Difference in viability of crosslinking agents from high-throughput screen.
Data Supplement from Targeted Deletion and Lipidomic Analysis Identify Epithelial Cell COX-2 as a Major Driver of Chemically Induced Skin Cancer
Authors: Jiao Jing , Ishikawa Tomo-O , Dumlao Darren S. , Norris Paul C. , Magyar Clara E. , Mikulec Carol , Catapang Art , Dennis Edward A. , Fischer Susan M. , Herschman Harvey R.
Published: April 2023

Epithelial thickness in response to short term DMBA/TPA treatment of Cox-2deltaE mice and their littermate Cox-2fl/fl mice (upper panels), and of Cox-2deltaM mice and their littermate Cox-2fl/fl mice (lower panels). Panels on the left show representative H&E skin sections, panels on the right show quantification of the results. Error bars are SD. * indicates p<0.05.
Figure S2 from Distinct Effects of Adipose-Derived Stem Cells and Adipocytes on Normal and Cancer Cell Hierarchy
Authors: Anjanappa Manjushree , Burnett Riesa , Zieger Michael A. , Merfeld-Clauss Stephanie , Wooden William , March Keith , Tholpady Sunil , Nakshatri Harikrishna
Published: April 2023

Cytokine array to identify cytokines secreted by ASCs and adipocytes
Supplementary Figure S4 from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model
Authors: Balestrini Alessia , Nicolas Laura , Yang-lott Katherine , Guryanova Olga A. , Levine Ross L. , Bassing Craig H. , Chaudhuri Jayanta , Petrini John H.J.
Published: April 2023

Chromosomal instability in primary B cells and immortalized MEFs
Figure S1 from Distinct Effects of Adipose-Derived Stem Cells and Adipocytes on Normal and Cancer Cell Hierarchy
Authors: Anjanappa Manjushree , Burnett Riesa , Zieger Michael A. , Merfeld-Clauss Stephanie , Wooden William , March Keith , Tholpady Sunil , Nakshatri Harikrishna
Published: April 2023

The effect of ASC CM on SUM225 cells
Supplementary Figure S3 F from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model
Authors: Balestrini Alessia , Nicolas Laura , Yang-lott Katherine , Guryanova Olga A. , Levine Ross L. , Bassing Craig H. , Chaudhuri Jayanta , Petrini John H.J.
Published: April 2023

Sμ-Sγ1 junctions
Supplementary Figure 1 from TGFβ Induces “BRCAness” and Sensitivity to PARP Inhibition in Breast Cancer by Regulating DNA-Repair Genes
Authors: Liu Liang , Zhou Weiying , Cheng Chun-Ting , Ren Xiubao , Somlo George , Fong Miranda Y. , Chin Andrew R. , Li Hui , Yu Yang , Xu Yang , O'Connor Sean Timothy Francis , O'Connor Timothy R. , Ann David K. , Stark Jeremy M. , Wang Shizhen Emily
Published: April 2023

Figure S1. Effect of TGFβ in BT474 and MCF7 BC cells.
Supplementary Figure 3 from Actin-Binding Protein, Espin: A Novel Metastatic Regulator for Melanoma
Authors: Yanagishita Takeshi , Yajima Ichiro , Kumasaka Mayuko , Kawamoto Yoshiyuki , Tsuzuki Toyonori , Matsumoto Yoshinari , Watanabe Daisuke , Kato Masashi
Published: April 2023

PDF file - 138K, Specification of anti-Espin-ru antibody.
Data Supplement from Bioactive Lipids, LPC and LPA, Are Novel Prometastatic Factors and Their Tissue Levels Increase in Response to Radio/Chemotherapy
Authors: Schneider Gabriela , Sellers Zachariah Payne , Abdel-Latif Ahmed , Morris Andrew J. , Ratajczak Mariusz Z.
Published: April 2023

Supplementary Figure 2. qRT-PCR-based analysis of LPA and LPC receptor expression in ARMs and ERMS cells lines. Panel A - LPAR1, LPAR2, and LPAR3 receptors. Panel B - G2A and GPR4 receptors. Combined data from two independent experiments are shown.
Supplementary Figure 2 from Autotaxin and LPA1 and LPA5 Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis
Authors: Lee Sue-Chin , Fujiwara Yuko , Liu Jianxiong , Yue Junming , Shimizu Yoshibumi , Norman Derek D. , Wang Yaohong , Tsukahara Ryoko , Szabo Erzsebet , Patil Renukadevi , Banerjee Souvik , Miller Duane D. , Balazs Louisa , Ghosh Manik C. , Waters Christopher M. , Oravecz Tamas , Tigyi Gabor J.
Published: April 2023

Supplementary Figure 2. LPA1-5 receptor profiling in whole lung tissue isolated from WT, LPA1-, LPA2- and LPA5KO mice, respectively using quantitative real-time PCR. Data are expressed as mean {plus minus} SEM (n = 3 mice).
Data Supplement from Adenosine Inhibits Tumor Cell Invasion via Receptor-Independent Mechanisms
Authors: Virtanen Sanna S. , Kukkonen-Macchi Anu , Vainio Minna , Elima Kati , Härkönen Pirkko L. , Jalkanen Sirpa , Yegutkin Gennady G.
Published: April 2023

Supplementary Figure S2. The effect of adenosine on the kinetics of cell adhesion to extracellular matrix and MMP secretion by PC-3 cells.
Supplementary Figures S1-S4 from Stromal Senescence By Prolonged CDK4/6 Inhibition Potentiates Tumor Growth
Authors: Guan Xiangnan , LaPak Kyle M. , Hennessey Rebecca C. , Yu Christina Y. , Shakya Reena , Zhang Jianying , Burd Christin E.
Published: April 2023

Figure S1. Activation of p38 is not observed in CDK4/6i fibroblasts. Figure S2. The response of melanoma cells to co-culture conditioned media is genotype dependent. Figure S3. Senescent fibroblasts promote the growth of B16-F1 melanomas. Figure S4. Co-injection of CDK4/6i fibroblasts does not alter the number of melanoma-associated F4/80- and FoxP3-positive immune cells.
Dataset S3 from Stromal Senescence By Prolonged CDK4/6 Inhibition Potentiates Tumor Growth
Authors: Guan Xiangnan , LaPak Kyle M. , Hennessey Rebecca C. , Yu Christina Y. , Shakya Reena , Zhang Jianying , Burd Christin E.
Published: April 2023

Cytokine expression in fibroblast conditioned media.
Figure S5 from p120-Catenin Downregulation and PIK3CA Mutations Cooperate to Induce Invasion through MMP1 in HNSCC
Authors: Kidacki Michal , Lehman Heather L. , Green Michelle V. , Warrick Joshua I. , Stairs Douglas B.
Published: April 2023

Western blot analysis of MMP14 expression. A, Examination of MMP14 expression by Western blot analysis in NOK cells and B, in EPC1 cells. β-ACTIN is used as a loading control.
Figure S3 from p120-Catenin Downregulation and PIK3CA Mutations Cooperate to Induce Invasion through MMP1 in HNSCC
Authors: Kidacki Michal , Lehman Heather L. , Green Michelle V. , Warrick Joshua I. , Stairs Douglas B.
Published: April 2023

Immunohistochemistry of NOK 3D organotypic cultures. A, 3D cultures were stained for P120CTN and B, E-cadherin. Scale bars = 50μm. n=3.
Data Supplement from Targeting mTORC1–Mediated Metabolic Addiction Overcomes Fludarabine Resistance in Malignant B Cells
Authors: Sharma Arishya , Janocha Allison J. , Hill Brian T. , Smith Mitchell R. , Erzurum Serpil C. , Almasan Alexandru
Published: April 2023

Supplementary Legend for Figure S1. P70S6k knockdown does not impact on cell death in Nalm-6 cells. (a) Western blot analysis of p70S6K knockdown in Nalm-6 cells. β-actin was used as a loading control. (b). Cell death analysis in siControl and si-p70S6K-expressing Nalm-6 cells, as determined by annexin V/PI staining.
Video 4 from Therapeutic Targeting of Nuclear γ-Tubulin in RB1-Negative Tumors
Authors: Lindström Lisa , Villoutreix Bruno O. , Lehn Sophie , Hellsten Rebecka , Nilsson Elise , Crneta Enisa , Olsson Roger , Alvarado-Kristensson Maria
Published: April 2023

Video 4. Differential Interference Contrast (DIC)/fluorescence time-lapse microscopy images of a mitotic MCF10A cell treated with 100 ÃŽÂ¼M CDA. Hoechst 33258 was used to stain chromatin. Images were collected every 30 s.
Supplemental Video 1 from The Cytoskeletal Adapter Protein Spinophilin Regulates Invadopodia Dynamics and Tumor Cell Invasion in Glioblastoma
Authors: Cheerathodi Mujeeburahiman , Avci Naze G. , Guerrero Paola A. , Tang Leung K. , Popp Julia , Morales John E. , Chen Zhihua , Carnero Amancio , Lang Frederick F. , Ballif Bryan A. , Rivera Gonzalo M. , McCarty Joseph H.
Published: April 2023

Raich-Rac1 Imaging, video 1
Supplementary figure S4 from Therapeutic Targeting of Nuclear γ-Tubulin in RB1-Negative Tumors
Authors: Lindström Lisa , Villoutreix Bruno O. , Lehn Sophie , Hellsten Rebecka , Nilsson Elise , Crneta Enisa , Olsson Roger , Alvarado-Kristensson Maria
Published: April 2023

Supplementary figure S4. The effect of the vehicle, Miglyol Oil 812, in the body weight of treated mice xenografted with U1690 cells.
Supplementary Figure 3 from Mcl-1 Mediates TWEAK/Fn14-Induced Non–Small Cell Lung Cancer Survival and Therapeutic Response
Authors: Whitsett Timothy G. , Mathews Ian T. , Cardone Michael H. , Lena Ryan J. , Pierceall William E. , Bittner Michael , Sima Chao , LoBello Janine , Weiss Glen J. , Tran Nhan L.
Published: April 2023

PDF file - 61K, Mcl-1 gene expression correlates with higher stage and worse prognosis in NSCLC.
Supplementary Table S1 from Differential Response of Glioma Stem Cells to Arsenic Trioxide Therapy Is Regulated by MNK1 and mRNA Translation
Authors: Bell Jonathan B. , Eckerdt Frank , Dhruv Harshil D. , Finlay Darren , Peng Sen , Kim Seungchan , Kroczynska Barbara , Beauchamp Elspeth M. , Alley Kristen , Clymer Jessica , Goldman Stewart , Cheng Shi-Yuan , James C. David , Nakano Ichiro , Horbinski Craig , Mazar Andrew P. , Vuori Kristiina , Kumthekar Priya , Raizer Jeffrey , Berens Michael E. , Platanias Leonidas C.
Published: April 2023

This table shows the initial cell viability screen in GBM cells. Relates to Figure 1C.
Table S6 from Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-catenin Signaling
Authors: Emons Georg , Spitzner Melanie , Reineke Sebastian , Möller Janneke , Auslander Noam , Kramer Frank , Hu Yue , Beissbarth Tim , Wolff Hendrik A. , Rave-Fränk Margret , Heßmann Elisabeth , Gaedcke Jochen , Ghadimi B. Michael , Johnsen Steven A. , Ried Thomas , Grade Marian
Published: April 2023

(A) Significantly upregulated Wnt genes comparing SW1463RES to SW1463. Differentially expressed genes (B) between SW1463, and SW1463 six hours after exposure to a single dose of 4 Gy of X-rays (SW1463-4 Gy). Differentially expressed genes (C) between SW1463RES, and SW1463RES six hours after exposure to a single dose of 4 Gy of X-rays (SW1463RES-4 Gy).
Suppl Data FIgure legends from USP6 Confers Sensitivity to IFN-Mediated Apoptosis through Modulation of TRAIL Signaling in Ewing Sarcoma
Authors: Henrich Ian C. , Young Robert , Quick Laura , Oliveira Andre M. , Chou Margaret M.
Published: April 2023

Figure legends for Supplemental Data
Table S4 from Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-catenin Signaling
Authors: Emons Georg , Spitzner Melanie , Reineke Sebastian , Möller Janneke , Auslander Noam , Kramer Frank , Hu Yue , Beissbarth Tim , Wolff Hendrik A. , Rave-Fränk Margret , Heßmann Elisabeth , Gaedcke Jochen , Ghadimi B. Michael , Johnsen Steven A. , Ried Thomas , Grade Marian
Published: April 2023

Experimental conditions for Western blot analyses.
Figure S4 from Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-catenin Signaling
Authors: Emons Georg , Spitzner Melanie , Reineke Sebastian , Möller Janneke , Auslander Noam , Kramer Frank , Hu Yue , Beissbarth Tim , Wolff Hendrik A. , Rave-Fränk Margret , Heßmann Elisabeth , Gaedcke Jochen , Ghadimi B. Michael , Johnsen Steven A. , Ried Thomas , Grade Marian
Published: April 2023

Schematic model of the chemoradiation treatment after Wnt-3a stimulation.
Figure S1 from Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-catenin Signaling
Authors: Emons Georg , Spitzner Melanie , Reineke Sebastian , Möller Janneke , Auslander Noam , Kramer Frank , Hu Yue , Beissbarth Tim , Wolff Hendrik A. , Rave-Fränk Margret , Heßmann Elisabeth , Gaedcke Jochen , Ghadimi B. Michael , Johnsen Steven A. , Ried Thomas , Grade Marian
Published: April 2023

Western blot analysis of (A) LS1034, (B) SW480, and (C) SW837 cells 24, 48, 72, and 96 hours after transfection with siRNAs targeting β-catenin, and a non-silencing control siRNA (siNEG).
Supplementary Figure 3 from mTOR Inhibition Potentiates HSP90 Inhibitor Activity via Cessation of HSP Synthesis
Authors: Acquaviva Jaime , He Suqin , Sang Jim , Smith Donald L. , Sequeira Manuel , Zhang Chaohua , Bates Richard C. , Proia David A.
Published: April 2023

PDF file - 583K, Modulation of nuclear HSF1 expression by BEZ235 following ganetespib pre-treatment.
Video S2 from Dual Targeting of Mesenchymal and Amoeboid Motility Hinders Metastatic Behavior
Authors: Jones Brandon C. , Kelley Laura C. , Loskutov Yuriy V. , Marinak Kristina M. , Kozyreva Varvara K. , Smolkin Matthew B. , Pugacheva Elena N.
Published: April 2023

Ibidi chemotactic invasion of MDA-MB-231 cells with CRISPR sgNEDD9 depletion
Supplementary Figures 1-10, Table and Materials and Methods from Dual Targeting of Mesenchymal and Amoeboid Motility Hinders Metastatic Behavior
Authors: Jones Brandon C. , Kelley Laura C. , Loskutov Yuriy V. , Marinak Kristina M. , Kozyreva Varvara K. , Smolkin Matthew B. , Pugacheva Elena N.
Published: April 2023

Fig. S1. NEDD9 depletion causes a switch to amoeboid morphology. Fig. S2. NEDD9 depletion decreases phosphorylation of focal adhesion proteins in other BC cell lines. Fig. S3. NEDD9 depletion affects vinculin-containing focal adhesion dynamics. Fig. S4. NEDD9 depletion affects talin-containing focal adhesion dynamics. Fig. S5. AURKA phosphorylates CTTN in breast cancer cells. Fig. S6. NEDD9 depletion decreases Rac1 activity in other breast cancer cell lines. Fig. S7. Depletion of NEDD9 via CRISPR-Cas9 system and overexpression of CA-RhoA decreases cell invasion and increases round amoeboid phenotype. Fig. S8. Simultaneous inhibition of mesenchymal and amoeboid pathways through NEDD9 and RhoA knockdown hinders cell invasion in vitro. Fig. S9. Depletion of NEDD9 hinders invasion of other breast cancer cell lines in vitro. Fig. S10. AURKA inhibition hinders breast cancer cell invasion.
Supplementary Figures 1 - 2 from MicroRNA-26a/b Regulate DNA Replication Licensing, Tumorigenesis, and Prognosis by Targeting CDC6 in Lung Cancer
Authors: Zhang Xin , Xiao Dakai , Wang Ziyi , Zou Yongxin , Huang Liyan , Lin Weixuan , Deng Qiuhua , Pan Hui , Zhou Jiangfen , Liang Chun , He Jianxing
Published: April 2023

Supplementary Fig. 1 Confirmation of cell synchronisation at the G1/S boundary. H1299 cells with or without prior transfection with plasmids expressing GFP-tagged CDC6 or GFP alone were transfected twice with the indicated miRNA mimics or control RNA. Untreated cells and those treated with the transfection reagent alone were used for comparison. Some 48 hrs after the final transfection, cells were synchronised at the G1/S boundary with mimosine, and the cell synchrony was determined by flow cytometry. Supplementary Fig. 2 MicroRNA-26a/b inhibit pre-replicative complex formation and cell cycle progression by suppressing CDC6 in human lung cancer cells. (A) SPAC cells with or without prior transfection with plasmids expressing GFP-tagged CDC6 or GFP alone were transfected twice with the indicated miRNA mimics or control RNA. Untreated cells and those treated with the transfection reagent alone were used for comparison. Some 48 hrs post transfection, cells were synchronized at the G1/S boundary with mimosine, and chromatin binding assay was performed with an aliquot of each cell sample. (B) The remaining cells were then released into fresh medium and harvested at different time points for FACS analysis.
Fig S3 from Exploiting AR-Regulated Drug Transport to Induce Sensitivity to the Survivin Inhibitor YM155
Authors: Nyquist Michael D. , Corella Alexandra , Burns John , Coleman Ilsa , Gao Shuai , Tharakan Robin , Riggan Luke , Cai Changmeng , Corey Eva , Nelson Peter S. , Mostaghel Elahe A.
Published: April 2023

Fig S3. Tumor Androgen Levels Correlate with SLC35F2 Expression
Supplementary Figure 1 from Dual Promoter Usage as Regulatory Mechanism of let-7c Expression in Leukemic and Solid Tumors
Authors: Pelosi Andrea , Careccia Silvia , Sagrestani Giulia , Nanni Simona , Manni Isabella , Schinzari Valeria , Martens Joost H.A. , Farsetti Antonella , Stunnenberg Hendrik G. , Gentileschi Maria Pia , Del Bufalo Donatella , De Maria Ruggero , Piaggio Giulia , Rizzo Maria Giulia
Published: April 2023

PDF file - 549KB, S1. Cartoon of the promoter region of both host gene (LINC00478) and intronic let-7c with elements and all primers used.
SUPPLEMENTARY FILES 1 to 7 from An Integrative Approach Uncovers Biomarkers that Associate with Clinically Relevant Disease Outcomes in Vulvar Carcinoma
Authors: Lavorato-Rocha Andre M. , Akagi Erica M. , de Melo Maia Beatriz , Rodrigues Iara S. , Botelho Mayara Caroline Silva , Marchi Fabio A. , Fernandes Gabriel , Baiocchi Glauco , Soares Fernando A. , Rogatto Silvia Regina , Sato-Kuwabara Yukie , Rocha Rafael M.
Published: April 2023

S1. Sequence and conditions of GNB3 and PLXDC2 primers for RT-PCR. S2. Significantly altered regions present in more than twenty percent of the samples based aCGH data and performed in NEXUS software. S3. Association of 47 possible modulators expression in vulvar squamous cell carcinoma and clinical and pathological variables. S4. Association of 47 possible modulators expression in vulvar squamous cell carcinoma and clinical and pathological variables. S5. Functions associated with the 47 driver candidates. Evaluation performed using Ingenuity Pathways Analysis and KOBAS 2.0. S6. Relative and absolute quantification of GNB3 and PLXDC2. S7. Association between PLXDC2 and GNB3 expression and clinical and pathological variables (Mann-Whitney test).
Supplementary Tables from Nuclear Localized LSR: A Novel Regulator of Breast Cancer Behavior and Tumorigenesis
Authors: Reaves Denise K. , Hoadley Katherine A. , Fagan-Solis Katerina D. , Jima Dereje D. , Bereman Michael , Thorpe Lynnelle , Hicks Jyla , McDonald David , Troester Melissa A. , Perou Charles M. , Fleming Jodie M.
Published: April 2023

Supplementary Table 1. Mutations in LSR from Human Cancer Samples. Supplementary Table 2. Potential post-translational modification sites of LSR transcript variants.
Supplementary Information from Nuclear Localized LSR: A Novel Regulator of Breast Cancer Behavior and Tumorigenesis
Authors: Reaves Denise K. , Hoadley Katherine A. , Fagan-Solis Katerina D. , Jima Dereje D. , Bereman Michael , Thorpe Lynnelle , Hicks Jyla , McDonald David , Troester Melissa A. , Perou Charles M. , Fleming Jodie M.
Published: April 2023

Supplementary Information including supplementary figure legends and supplementary table titles
Supplemental Excel File 8 from A New Role for ERα: Silencing via DNA Methylation of Basal, Stem Cell, and EMT Genes
Authors: Ariazi Eric A. , Taylor John C. , Black Michael A. , Nicolas Emmanuelle , Slifker Michael J. , Azzam Diana J. , Boyd Jeff
Published: April 2023

Supplemental Excel File 8 - DAC-induced genes in T47D cells
Supplemental Excel File 7 from A New Role for ERα: Silencing via DNA Methylation of Basal, Stem Cell, and EMT Genes
Authors: Ariazi Eric A. , Taylor John C. , Black Michael A. , Nicolas Emmanuelle , Slifker Michael J. , Azzam Diana J. , Boyd Jeff
Published: April 2023

Supplemental Excel File 7 - Consensus ERalpha Directly-related Genes
Supplemental Excel File 3 from A New Role for ERα: Silencing via DNA Methylation of Basal, Stem Cell, and EMT Genes
Authors: Ariazi Eric A. , Taylor John C. , Black Michael A. , Nicolas Emmanuelle , Slifker Michael J. , Azzam Diana J. , Boyd Jeff
Published: April 2023

Supplemental Excel File 3 - Down-regulated Genes Associated with Antihormone resistance
Supplemental Excel File 2 from A New Role for ERα: Silencing via DNA Methylation of Basal, Stem Cell, and EMT Genes
Authors: Ariazi Eric A. , Taylor John C. , Black Michael A. , Nicolas Emmanuelle , Slifker Michael J. , Azzam Diana J. , Boyd Jeff
Published: April 2023

Supplemental Excel File 2 - Up-regulated Genes Associated with Antihormone resistance.
Pyrosequencing Assay positions from A New Role for ERα: Silencing via DNA Methylation of Basal, Stem Cell, and EMT Genes
Authors: Ariazi Eric A. , Taylor John C. , Black Michael A. , Nicolas Emmanuelle , Slifker Michael J. , Azzam Diana J. , Boyd Jeff
Published: April 2023

Table showing Pyrosequencing Assay Interrogation Positions
Data Supplement from SMAD4 Suppresses AURKA-Induced Metastatic Phenotypes via Degradation of AURKA in a TGFβ-Independent Manner
Authors: Jia Lina , Lee Hun Seok , Wu Chun Fu , Kundu Juthika , Park Sang Gyu , Kim Ryong Nam , Wang Li-Hui , Erkin Özgür Cem , Choi Jong-Sun , Chae Seoung Wan , Yang Ho Bin , Choi Yoon-La , Shin Young Kee
Published: April 2023

Supplementary Figure 1C. AGS, SW480, and HeLa cells were pretreated with control siRNA (lane 1 and 2) or AURKA siRNA (10 nM, lane 3 and 4) for 48 h, and transfected with the plasmid encoding 6Myc-SMAD4 or empty vector. Cells were collected 24 h after transfection and subjected to cell migration and invasion assay (n=3). Data were presented as means {plus minus}SD obtained from three independent experiments (*P<0.05, Ã¢?Â P<0.01, Ã¢?Â¡P<0.001, compared to the control group).
Supplementary Figure 5 from Loss of Keratinocytic RXRα Combined with Activated CDK4 or Oncogenic NRAS Generates UVB-Induced Melanomas via Loss of p53 and PTEN in the Tumor Microenvironment
Authors: Coleman Daniel J. , Chagani Sharmeen , Hyter Stephen , Sherman Anna M. , Löhr Christiane V. , Liang Xiaobo , Ganguli-Indra Gitali , Indra Arup K.
Published: April 2023

Supplementary Figure S5: No change in infiltrating mast cells as determined by CEM staining is observed in melanocytic lesions from either Cdk4R24c or Tyr-NRASQ61K mice with epidermis-specific knockout of Rxra. Assay was performed on bleached 5 J.lm paraffin sections. Infiltrating mast cells are labeled with light blue staining. E=Epidermis, 0= Dermis. Scale bars= 50 micron
Supplemental Tables 1-2 & Figures 1-4 from Intrinsic Resistance to Cixutumumab Is Conferred by Distinct Isoforms of the Insulin Receptor
Authors: Forest Amelie , Amatulli Michael , Ludwig Dale L. , Damoci Christopher B. , Wang Ying , Burns Colleen A. , Donoho Gregory P. , Zanella Nina , Fiebig Heinz H. , Prewett Marie C. , Surguladze David , DeLigio James T. , Houghton Peter J. , Smith Malcolm A. , Novosiadly Ruslan
Published: April 2023

Supplemental Tables 1-2 & Figures 1-4. Supplemental Table 1. Total IR, IR-A, IR-B, IGF-IR, IGF-I and IGF-II mRNA expression in preclinical models of pediatric solid tumors. Supplemental Table 2. Patient-derived xenograft models of lung adenocarcinoma: clinical information and mutational status. Supplemental Figure 1. Effect of cixutumumab on circulating growth hormone (A), insulin (B) and IGF-I (C) levels in male C57BL/6 mice. Represented are mean values +/- SEM. p-values {less than or equal to} 0.05 indicate statistical significance (*) (Student's t-test). Supplemental Figure 2. IGF-I and IGF-II mRNA expression in patient-derived models of lung adenocarcinoma. Represented are mean values +/- SEM. Supplemental Figure 3. Overlay analysis of cell surface IR and IGF-IR expression by flow cytometry (A) and ligand-induced signal transduction by Western Blot (B) in A549 cell overexpressing empty vector (pLVX) or IR isoforms (IR-A and IR-B). Serum-starved cells (1h) were treated with rhIGF-I, rhIGF-II or recombinant human insulin (10 nM) for 5, 15 or 60 minutes. Proteins (10ug) extracted from cultured cells were size-fractionated by SDS-PAGE and immunoblotted with anti-phospho-IRbY1150/51/IGF-IRbY1135/36, anti-phospho-AktS473 and anti-phospho-p42/p44 MAPKT202/Y204 antibodies. Total level of proteins was demonstrated by immunoblotting with antibodies directed against total Akt and p42/p44 MAPK. Supplemental Figure 4. Anchorage-dependent cell viability assay. MCF-7-Mock, MCF-7-IR-A and MCF-7-IRB cells were treated with increasing concentrations of cixutumumab (0.015-1,000 nM). Maximum inhibition for MCF-7-Mock, MCF-7-IR-A and MCF-7-IRB were 60.4%, 0% and 26.9% respectively, p-values < 0.01(Student's t-test). Represented are mean values +/- SEM.
Supplementary Table S2 from Let-7 Status Is Crucial for PARP1 Expression in HER2-Overexpressing Breast Tumors
Authors: Wielgos Monica E. , Rajbhandari Rajani , Cooper Tiffiny S. , Wei Shi , Nozell Susan , Yang Eddy S.
Published: April 2023

Patient characteristics for breast tumors analyzed for let-7a and PARP1 expression.
Supplemental Information from MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase
Authors: Posternak Valeriya , Ung Matthew H. , Cheng Chao , Cole Michael D.
Published: April 2023

Description of supplemental data
Supplemental Figure legends from AMPKα2 Regulates Bladder Cancer Growth through SKP2-Mediated Degradation of p27
Authors: Kopsiaftis Stavros , Sullivan Katie L. , Garg Isha , Taylor John A. , Claffey Kevin P.
Published: April 2023

Supplemental Figure legends
Supplementary Figure Legend from VEGFR-1 Pseudogene Expression and Regulatory Function in Human Colorectal Cancer Cells
Authors: Ye Xiangcang , Fan Fan , Bhattacharya Rajat , Bellister Seth , Boulbes Delphine R. , Wang Rui , Xia Ling , Ivan Cristina , Zheng Xiaofeng , Calin George A. , Wang Jing , Lu Xiongbin , Ellis Lee M.
Published: April 2023

Supplementary Figure Legend. Supplementary Figure Legend
Data Supplement from SNF5/INI1 Deficiency Redefines Chromatin Remodeling Complex Composition during Tumor Development
Authors: Wei Darmood , Goldfarb Dennis , Song Shujie , Cannon Courtney , Yan Feng , Sakellariou-Thompson Donastas , Emanuele Michael , Major Michael B. , Weissman Bernard E. , Kuwahara Yasumichi
Published: April 2023

Supplementary Figure S2. This figure demonstrates the onset of replicative senescence after SNF5 KD in normal human fibroblasts.
Supplementary Figures 1 - 6, Table 1 from Therapeutic Efficacy of p53 Restoration in Mdm2-Overexpressing Tumors
Authors: Li Qin , Zhang Yun , El-Naggar Adel K. , Xiong Shunbin , Yang Peirong , Jackson James G. , Chau Gilda , Lozano Guillermina
Published: April 2023

PDF file - 354K, Figure S1. Tumor-free survival curves of the Mdm2Tg p53Neo/Neo and Mdm2Tg p53Neo/Neo CreER mice. Figure S2. Analysis of p53Neo recombination in tamoxifen-treated Mdm2Tg p53Neo/Neo CreER tumors. Figure S3. Initial tumor volumes of the Mdm2Tg p53Neo/Neo and Mdm2Tg p53Neo/Neo CreER angiosarcomas. Figure S4. p53 target gene p21 expression in tamoxifen-treated spontaneous Mdm2Tg p53Neo/Neo and Mdm2Tg p53Neo/Neo CreER angiosarcomas. Figure S5. PCR analysis of p53Neo allele recombination upon tamoxifen treatment in transplanted Mdm2Tg p53Neo/Neo CreER angiosarcomas. Figure S6. Effects of tamoxifen on the Mdm2Tgp53Neo/Neo angiosarcomas. Table S1. List of Mdm2Tg p53Neo/Neo and Mdm2Tg p53Neo/Neo CreER angiosarcomas monitored in the MRI study.
Supplementary Data from High-Affinity Internalizing Human scFv-Fc Antibody for Targeting FGFR1-Overexpressing Lung Cancer
Authors: Sokolowska-Wedzina Aleksandra , Chodaczek Grzegorz , Chudzian Julia , Borek Aleksandra , Zakrzewska Malgorzata , Otlewski Jacek
Published: April 2023

Supplementary Materials and Methods - Description of affinity maturation procedure used in the study and of the preparation of scFvD2 diabody and scFvD2-Fc; Supplementary Figure S1 - Reactivity of scFv clones against Fc fragment; Supplementary Figure S2 - Characteristics of affinity maturated scFvE2 clone; Supplementary Figure S3 - Lack of activation of FGFR1 by D2 antibodies; Supplementary Figure S4 - Internalization of FGF2 by lung cancer cells; Supplementary Figure S5 - Level of FGFR1 and internalization process of scFvD2-Fc by NCI-H1581 cells.
Supplemental figures 1-3, Table 1 from Astrocyte Elevated Gene-1 Regulates β-Catenin Signaling to Maintain Glioma Stem-like Stemness and Self-Renewal
Authors: Hu Bin , Emdad Luni , Kegelman Timothy P. , Shen Xue-Ning , Das Swadesh K. , Sarkar Devanand , Fisher Paul B.
Published: April 2023

S1. Primary GBM neurospheres have higher AEG-1 expression than neuronal stem cells. S2. Primary GBM neurospheres sorted with the CD133 GSC cell surface marker. S3. Isolated GSCs show enhanced expression of the stem cell marker SOX2 and are capable of differentiating into astrocytes and neurons. Supplemental Table 1. Comparison of normalized expression levels of each protein for Western blots in Figure 2B.
Supplementary Figure 2 from ERβ Regulates NSCLC Phenotypes by Controlling Oncogenic RAS Signaling
Authors: Nikolos Fotis , Thomas Christoforos , Rajapaksa Gayani , Bado Igor , Gustafsson Jan-Åke
Published: April 2023

PDF file - 693K, S2. ERbeta1 reduces cell proliferation in NSCLC cells.
Supplementary Figure 9 from Whole Transcriptome Sequencing Reveals Extensive Unspliced mRNA in Metastatic Castration-Resistant Prostate Cancer
Authors: Sowalsky Adam G. , Xia Zheng , Wang Liguo , Zhao Hao , Chen Shaoyong , Bubley Glenn J. , Balk Steven P. , Li Wei
Published: April 2023

Intron retention is not a sequencing or amplification artifact.
Supplementary Table 4 from Mutational Landscape of the Essential Autophagy Gene BECN1 in Human Cancers
Authors: Laddha Saurabh V. , Ganesan Shridar , Chan Chang S. , White Eileen
Published: April 2023

PDF file - 1450KB, Table S4. The types of somatic mutations found for BRCA1.
Supplementary Figure 6 from Whole Transcriptome Sequencing Reveals Extensive Unspliced mRNA in Metastatic Castration-Resistant Prostate Cancer
Authors: Sowalsky Adam G. , Xia Zheng , Wang Liguo , Zhao Hao , Chen Shaoyong , Bubley Glenn J. , Balk Steven P. , Li Wei
Published: April 2023

Extensive intronic coverage in a subset of genes.
Supplementary Figure 4 from Whole Transcriptome Sequencing Reveals Extensive Unspliced mRNA in Metastatic Castration-Resistant Prostate Cancer
Authors: Sowalsky Adam G. , Xia Zheng , Wang Liguo , Zhao Hao , Chen Shaoyong , Bubley Glenn J. , Balk Steven P. , Li Wei
Published: April 2023

Heatmap representation ERG expression in CRPC samples.
Supplementary Figure 2 from Whole Transcriptome Sequencing Reveals Extensive Unspliced mRNA in Metastatic Castration-Resistant Prostate Cancer
Authors: Sowalsky Adam G. , Xia Zheng , Wang Liguo , Zhao Hao , Chen Shaoyong , Bubley Glenn J. , Balk Steven P. , Li Wei
Published: April 2023

EPB41L5:PCDP1 fusion transcript detected in CRPC 49.
Supplementary Figure 10 from Whole Transcriptome Sequencing Reveals Extensive Unspliced mRNA in Metastatic Castration-Resistant Prostate Cancer
Authors: Sowalsky Adam G. , Xia Zheng , Wang Liguo , Zhao Hao , Chen Shaoyong , Bubley Glenn J. , Balk Steven P. , Li Wei
Published: April 2023

High-confidence fusion transcripts detected in CRPC.
Supplemental Figure Legends from Targeting AR Variant–Coactivator Interactions to Exploit Prostate Cancer Vulnerabilities
Authors: Magani Fiorella , Peacock Stephanie O. , Rice Meghan A. , Martinez Maria J. , Greene Ann M. , Magani Pablo S. , Lyles Rolando , Weitz Jonathan R. , Burnstein Kerry L.
Published: April 2023

Figure Legends for Supp Fig. 1 and Supp. Fig 2
Supplementary Figure 1 from Whole Transcriptome Sequencing Reveals Extensive Unspliced mRNA in Metastatic Castration-Resistant Prostate Cancer
Authors: Sowalsky Adam G. , Xia Zheng , Wang Liguo , Zhao Hao , Chen Shaoyong , Bubley Glenn J. , Balk Steven P. , Li Wei
Published: April 2023

Positive correlation between gene expression platforms in CRPC samples.
Supplementary Figure 3 from P-Cadherin Promotes Ovarian Cancer Dissemination Through Tumor Cell Aggregation and Tumor–Peritoneum Interactions
Authors: Usui Akihiro , Ko Song Yi , Barengo Nicolas , Naora Honami
Published: April 2023

PDF file - 2105K, Supplemental Figure S3. Inhibition of P-cadherin but not of Rac1 and Cdc42 blocks aggregation of SKOV3ip cells.
Neurosphere formation_control from Phostine PST3.1a Targets MGAT5 and Inhibits Glioblastoma-Initiating Cell Invasiveness and Proliferation
Authors: Hassani Zahra , Saleh Ali , Turpault Soumaya , Khiati Salim , Morelle Willy , Vignon Jacques , Hugnot Jean-Philippe , Uro-Coste Emmanuelle , Legrand Philippe , Delaforge Marcel , Loiseau Séverine , Clarion Ludovic , Lecouvey Marc , Volle Jean-Noël , Virieux David , Pirat Jean-Luc , Duffau Hugues , Bakalara Norbert
Published: April 2023

Time lapse showing cell aggregation during neurosphere formation in control condition.
RNA-seq Gene List from EWS/FLI is a Master Regulator of Metabolic Reprogramming in Ewing Sarcoma
Authors: Tanner Jason M. , Bensard Claire , Wei Peng , Krah Nathan M. , Schell John C. , Gardiner Jamie , Schiffman Joshua , Lessnick Stephen L. , Rutter Jared
Published: April 2023

List of differentially expressed genes from RNA-seq analysis of A673 cells, shEF vs. shLUC.
Neurosphere formation_PST3.1a-treated from Phostine PST3.1a Targets MGAT5 and Inhibits Glioblastoma-Initiating Cell Invasiveness and Proliferation
Authors: Hassani Zahra , Saleh Ali , Turpault Soumaya , Khiati Salim , Morelle Willy , Vignon Jacques , Hugnot Jean-Philippe , Uro-Coste Emmanuelle , Legrand Philippe , Delaforge Marcel , Loiseau Séverine , Clarion Ludovic , Lecouvey Marc , Volle Jean-Noël , Virieux David , Pirat Jean-Luc , Duffau Hugues , Bakalara Norbert
Published: April 2023

Time lapse showing cell aggregation during neurosphere formation in PST3.1a-treated condition. In this condition, less cell aggregation is visible as compared to the control condition.
Figure S3 from EWS/FLI is a Master Regulator of Metabolic Reprogramming in Ewing Sarcoma
Authors: Tanner Jason M. , Bensard Claire , Wei Peng , Krah Nathan M. , Schell John C. , Gardiner Jamie , Schiffman Joshua , Lessnick Stephen L. , Rutter Jared
Published: April 2023

Cancer Cell Line Encyclopedia plot for PHGDH and additional SurvExpress plots.
Supplemental Figure S3 from CD44 Regulates Pancreatic Cancer Invasion through MT1-MMP
Authors: Jiang Wei , Zhang Yaqing , Kane Kevin T. , Collins Meredith A. , Simeone Diane M. , di Magliano Marina Pasca , Nguyen Kevin Tri
Published: April 2023

CD44 regulation of Snail expression.
Supplementary Figure 2. from HDAC Inhibition for the Treatment of Epithelioid Sarcoma: Novel Cross Talk Between Epigenetic Components
Authors: Lopez Gonzalo , Song Yechun , Lam Ryan , Ruder Dennis , Creighton Chad J. , Bid Hemant Kumar , Bill Kate Lynn , Bolshakov Svetlana , Zhang Xiaoli , Lev Dina , Pollock Raphael E.
Published: April 2023

HDACi reduces EZH2 RNA and protein expression.
Supplementary Figure 1 from HDAC Inhibition for the Treatment of Epithelioid Sarcoma: Novel Cross Talk Between Epigenetic Components
Authors: Lopez Gonzalo , Song Yechun , Lam Ryan , Ruder Dennis , Creighton Chad J. , Bid Hemant Kumar , Bill Kate Lynn , Bolshakov Svetlana , Zhang Xiaoli , Lev Dina , Pollock Raphael E.
Published: April 2023

HDACi abrogates ES colony formation.
Misek et al Supplementary Data from EGFR Signals through a DOCK180-MLK3 Axis to Drive Glioblastoma Cell Invasion
Authors: Misek Sean A. , Chen Jian , Schroeder Laura , Rattanasinchai Chotirat , Sample Ashley , Sarkaria Jann N. , Gallo Kathleen A.
Published: April 2023

The effect of CEP-1347 on glioblastoma cell line viability.
Supplementary Figures 1 - 3, Table 1 from SIRT1 Inactivation Evokes Antitumor Activities in NSCLC through the Tumor Suppressor p27
Authors: Zhu Lijia , Chiao Christine Y. , Enzer Katelyn G. , Stankiewicz Alexander J. , Faller Douglas V. , Dai Yan
Published: April 2023

Fig.S1: The level of p27Kip1 mRNA was unaffected by SIRT1 silencing. The mRNA levels of p27 were measured by quantitative RT-PCR analysis. 5 mg RNA extracted from SIRT1 silenced (shSIRT1) or shRNA control (shControl) H1299 and H460 cells. The mRNA levels of p27 are expressed relative to b-actin transcripts. Each experiment was performed in triplicate and repeated three times. The error bars represent the SEM. Fig.S2: SIRT1 silencing has no effect on apoptosis. Cell extracts were made from SIRT1- silenced and shRNA-control H1299 and H460 cells, and immunoblot analysis was performed with PARP and β-actin antibodies. Fig.S3: A. SIRT1 has no effect on p21 expression in both p53 wild type and p53 null cells. Cell extracts were made from SIRT1-silenced and shRNA-control H460 (p53+/+) and H1299 (p53-/-) cells, and immunoblot analysis was performed with anti-acetylated-p53, p21 and β-actin antibodies. B. p16 is deleted in NSCLC H460 and A549 cells. Cell extracts were made from SIRT1-silenced and shRNA-control H460 (p16-/-) and A549 (p16-/-) cells, or p16 wild type Hela cells. The immunoblot analysis was performed with anti-acetylated-p16, and β-actin antibodies. Table 1. The p27, p53 and p16 status in studied NSCLC cell lines.
Supplementary Figure Legend from Predictive Outcomes for HER2-enriched Cancer Using Growth and Metastasis Signatures Driven By SPARC
Authors: Güttlein Leandro N. , Benedetti Lorena G. , Fresno Cristóbal , Spallanzani Raúl G. , Mansilla Sabrina F. , Rotondaro Cecilia , Raffo Iraolagoitia Ximena L. , Salvatierra Edgardo , Bravo Alicia I. , Fernández Elmer A. , Gottifredi Vanesa , Zwirner Norberto W. , Llera Andrea S. , Podhajcer Osvaldo L.
Published: April 2023

This file contains legends of Supplementary Figures S1-S8