bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular genetic etiology by whole exome sequence analysis in cases with familial type 1 diabetes mellitus without HLA haplotype predisposition or incomplete predisposition
Authors: Yilmaz Uğur Cem , Evin Ferda , Onay Huseyin , Ozen Samim , Darcan Sukran , Simsek Damla Goksen
Published: November 2022

Objectives

Familial transmission is observed in approximately 10% of cases with type 1 diabetes mellitus (T1DM). The most important gene determining susceptibility is the human leukocyte antigen complex (HLA) located on chromosome 6. More than 50 susceptible loci are associated with T1DM susceptibility have been identified in genes other than HLA. In this study, it was aimed to investigate the molecular genetic etiology by whole-exome sequence (WES) analysis in cases with familial T1DM with no or weakly detected HLA tissue type susceptibility. We aimed to identify new genes responsible for the development of type 1 diabetes and to reveal new genes that have not been shown in the literature before.

Methods

Cases with at least one T1DM diagnosis in first-degree relatives were included in the study. In the first step, HLA DQ2 and DQ8 loci, which are known to be associated with T1DM susceptibility, were investigated by. In the second step, the presence of variants that could explain the situation was investigated by WES analysis in patients who were negative for both HLA DQ2 and HLA DQ8 haplotypes, HLA DQ2 negative, HLA DQ8 positive, and HLA DQ2 positive and HLA DQ8 negative patients.

Results

The mean age and duration of diabetes of the 30 cases (Girl/Male: 17/13) were 14.9 ± 6 and 7.56 ± 3.84 years, respectively. There was consanguineous marriage in 5 (16%) of the families. As a result of filtering all exome sequence analysis data of two cases with DQ2 (DQB1*02) (−) and DQ8 (DQB1*03:02) (−), seven cases with DQ2 (DQB1*02) (+) and DQ8 (DQB1*03:02) (−), and one case with DQ2 (DQB1*02) (−) and DQ8 (DQB1*03:02) (+), seven different variants in seven different genes were detected in five cases. The pathogenicity of the detected variants were determined according to the “American College of Medical Genetics and Genomics (ACMG)” criteria. These seven variants detected were evaluated as high-score VUS (Variants of unknown/uncertain significance). In the segregation study conducted for the mutation in the POLG gene detected in case 5, this variant was detected in the mother of the case and his brother with T1DM. Segregation studies are ongoing for variants detected in other affected individuals in the family.

Conclusions

In conclusion, in this study, seven different variants in seven different genes were detected in five patients by WES analysis in familial T1DM patients with no or weak HLA tissue type susceptibility. These seven variants detected were evaluated as high-score VUS. POLG might be a novel candidate gene responsible for susceptibility to T1DM. Non-HLA genes directly responsible for the development of T1DM were not detected in any of the cases.
Semantic Theory versus Semantic “Lumping”: Reply to Bertinetto et al. (2015) The acquisition of tense and aspect in a morphology-sensitive framework: data from Italian and Austrian-German children
Authors: Weist Richard M.
Published: November 2022

The crosslinguistic investigation of child language has revealed the frequent co-occurrence of certain values of Aktionsart, aspect and tense. Specifically, dynamic-atelic predicates are likely to be observed with unbounded values of aspect in the non-past tense and dynamic-telic predicates with bounded aspect and past tense morphology. This observation has motivated theories of language acquisition that incorporate the semantic structure of predicates in relation to clause structure. Pier Marco Bertinetto and colleagues have claimed that inferences regarding the role of predicate structure in the acquisition process have been erroneously derived from “lumping” together stative and activity predicates. Furthermore, without acknowledging the prior theory of “typological bootstrapping”, they present their presumably unique theory of information processing to explain their Italian and German child language data. The purpose of this reply is to show that the stative-activity “lumping” assertion is a “straw man” argument, and a theory of morphological information processing is both well-known and compatible with semantically based theories of acquisition.
Algorithms and methodological challenges in the development and application of quantitative systems pharmacology models: a case study in type 2 diabetes
Authors: Sokolov Victor
Published: November 2022

Quantitative systems pharmacology (QSP) is a relatively new modelling discipline, formed within the ever-growing domain of model-informed drug development and actively evolving throughout the last decade. This modelling technique is based on the systems analysis and is used to get a quantitative rather than qualitative understanding of systems dynamics and explore the mechanisms of action of a drug. However, there is no well-defined methodology for the QSP model development, which significantly complicates the practical application of these models. In the current work, we overview the existing mathematical models of antidiabetic therapies and propose a modelling method, which overcomes common limitations and is able to produce a physiologically based mechanistic model describing gliflozin action in type 2 diabetes mellitus. From the practical standpoint, sensitivity analysis preformed in this work helped to reveal subpopulation of patients with better response to gliflozin therapy.
Az elhalasztott kongresszus
Authors: Rostás Zoltán
Published: November 2022

A nemzetközi tudományos rendezvények elvitathatatlan legitimációs funkcióval rendelkeznek valamely tudományág hazai művelői számára, ám e legitimitás forrása nem csupán a rendezvény, hanem az ahhoz vezető út is lehet. Jó példa erre az 1939-re, bukaresti helyszínnel tervezett XIV. Nemzetközi Szociológiai Kongresszus, amelyet a háború kitörése miatt elhalasztottak ugyan, de az előkészítési munkálatok a bukaresti szociológiai iskolát a nemzetközi tudományos élet homlokterébe állították.
Venczel József szociálpolitikai gondolatai
Authors: Telegdy Balázs
Published: November 2022

Venczel József szakmai szocializációja a csíkszeredai Római Katolikus Főgimnáziumban kezdődött, már itt kialakult a szociális érzékenységgel párosuló katolikus látásmódja. Későbbi tanulmányai, az Erdélyi Fiatalok mozgalomban való részvétele, a Gusti-iskolával való kapcsolata, majd a Hitel megalakítása mind közelebb vitte eredeti céljaihoz: az erdélyi magyar falu segítéséhez. A falu felemelését kutatásra alapozott művelődés- és szociálpolitikai program végrehajtásával látta megvalósíthatónak.
Pszichoaktív szerhasználat kelet-baranyai általános- és középiskolások körében
Authors: Horváth Veronika , Molnár Dániel
Published: November 2022

A pszichoaktív szerekkel kapcsolatban számos kutatás látott napvilágot az elmúlt években. A kutatások jelentős része a középiskolás korosztály drogérintettségének feltérképezését célozza, de közvetett adatokból tudható, hogy a szerhasználat már a fiatalabb, általános iskolás fiatalok körében is megjelenik. Tanulmányukban kísérletet teszünk a rendelkezésre álló hazai kutatások összegző jellegű bemutatására. Ismertetjük továbbá saját, általános és középiskolás diákok körében, nettó 877 fős mintán végzett kérőíves kutatásunk fontosabb eredményeit.
Transformation kinetics for low temperature post-deposition crystallization of TiO2 thin films prepared via atomic layer deposition from TDMAT and water
Authors: Wooding Jamie P. , Gregory Shawn A. , Atassi Amalie , Freychet Guillaume , Kalaitzidou Kyriaki , Losego Mark D.
Published: November 2022

Background: We report on the fundamental crystallization kinetics of atomic layer deposited (ALD) TiO2 thin films undergoing a post-deposition anneal (PDA) at low temperatures to probe differences in the as-deposited film microstructure. Methods: The system of study is ALD TiO2 thin films prepared from tetrakis(dimethylamino)titanium(IV) (TDMAT) and water at 120 °C, 140 °C and 160 °C followed by ex situ low temperature annealing at temperatures ranging from 140 °C to 220 °C. All as-deposited TiO2 thin films are amorphous by X-ray diffraction (XRD). Post-deposition annealing (PDA) produces large grain anatase crystals, confirmed by XRD and top-view scanning electron microscopy (SEM). A detailed SEM study is performed to quantify the nucleation and growth kinetics by fitting microstructural data to the Johnson-Mehl-Avrami-Kolmogorov (JMAK) equation. Finally, a time-temperature-transformation (TTT) diagram is constructed to summarize the differences in crystallization behavior at different ALD deposition temperatures. Results and Conclusions: Fitting microstructural data to the JMAK equation reveals an Avrami exponent close to 3 with continuous nucleation, suggesting two-dimensional, plate-like crystal growth. Applying an Arrhenius relationship to the phase transformation data, the combined activation energy for nucleation and growth is found to be 1.40–1.58 eV atom-1. Nucleation rates are determined, and an Arrhenius relationship is used to calculate the critical Gibbs free energy for nucleation (~1.3-1.4 eV atom-1). As such, nucleation is the rate-limiting step for the amorphous to anatase phase transformation. ALD growth temperature is found to dictate film microstructure with lower deposition temperatures reducing the nucleation rate and leading to larger grain sizes irrespective of PDA conditions. The nucleation rate pre-exponential frequency factor increases with increasing deposition temperature, thereby increasing the likelihood for nucleation. Interestingly, it is this difference in the vibrational modes of the amorphous structure, as indicated by the variation in the nucleation rate pre-exponential frequency factor, that alters the phase transformation rates and not a change in the activation energies for the transformation.
Photodegradation, thermodynamic and kinetic study of cationic and anionic dyes from effluents using polyazomethine/ZnO and polyazomethine/TiO2 nanocomposites
Authors:   Department of Chemistry, Hindusthan College of Engineering and Technology, Coimbatore, TamilNadu, India, Pradeeba S. J. , Sampath K. ,   Department of Chemistry, Kumaraguru College of Technology, Coimbatore, Tamil Nadu, India
Published: November 2022

Water is a life-giving and energising substance. People all around the world are struggling due to the deficiency of fresh and hygienic potable water. Clean water is a significant resource for human civilization on Earth and one of the most crucial requirements for all living species to survive. Contamination of water due to synthetic dye is one of the most serious threats to human health. The photocatalystspoly(azomethine), ZnO, TiO2, poly(azomethine)/TiO2 and poly(azomethine)/ZnO were synthesized and used to remove cationic and anionic dyes from contaminated water.The band gap of photocatalysts, reaction kinetics, isotherm studies and thermodynamic studies were assessed and the photocatalytic studies revealed that polyazomethine/ZnO and polyazomethine/TiO2 nanocomposites had significantly higher photocatalytic activity and are more efficient at removing dyes from effluents than PAZ, ZnO, and TiO2 in natural sunlight.
Biomimetic tissue regeneration using electrospun nanofibrous scaffolds
Authors:   Medical Engineering Department, Faculty of Engineering, Al-Ahliyya Amman University, Amman, 19328, Jordan, Owida H. A. , Al-Ayyad M. ,   Medical Engineering Department, Faculty of Engineering, Al-Ahliyya Amman University, Amman, 19328, Jordan, Rashid M. ,   Civil Engineering Department, Faculty of Engineering, Al-Ahliyya Amman University, Amman, 19328, Jordan
Published: November 2022

An emerging field of tissue engineering combines medical, biological, and engineering principles to produce tissue-engineered constructs that regenerate, preserve, or slightly enhance the functions of natural tissue. By creating structures that replicate the extracellular matrix, oxygen and nutrients will be transmitted more effectively while releasing toxins during tissue repair, all while creating mature tissues. Three-dimensional nanostructures for tissue engineering have been the focus of numerous studies over the last few years. Electrospinning is a highly effective technique in this category. The last few decades, numerous nanofibrous scaffolds have been developed for tissue repair and restoration. Nanofibrous meshes as tissue engineered scaffolds for various tissues, such as neural, cardiovascular, skin, cartilage, and tendon are discussed in this article. In addition, the current article discusses recent advancements in tissue regeneration as well as challenges associated with electrospinning.
ZBTB2 links p53 deficiency to HIF‐1‐mediated hypoxia signaling to promote cancer aggressiveness
Authors: Koyasu Sho , Horita Shoichiro , Saito Keisuke , Kobayashi Minoru , Ishikita Hiroshi , Chow Christalle CT , Kambe Gouki , Nishikawa Shigeto , Menju Toshi , Morinibu Akiyo , Okochi Yasushi , Tabuchi Yoshiaki , Onodera Yasuhito , Takeda Norihiko , Date Hiroshi , Semenza Gregg L , Hammond Ester M , Harada Hiroshi
Published: November 2022

Aberrant activation of the hypoxia‐inducible transcription factor HIF‐1 and dysfunction of the tumor suppressor p53 have been reported to induce malignant phenotypes and therapy resistance of cancers. However, their mechanistic and functional relationship remains largely unknown. Here, we reveal a mechanism by which p53 deficiency triggers the activation of HIF‐1‐dependent hypoxia signaling and identify zinc finger and BTB domain‐containing protein 2 (ZBTB2) as an important mediator. ZBTB2 forms homodimers via its N‐terminus region and increases the transactivation activity of HIF‐1 only when functional p53 is absent. The ZBTB2 homodimer facilitates invasion, distant metastasis, and growth of p53‐deficient, but not p53‐proficient, cancers. The intratumoral expression levels of ZBTB2 are associated with poor prognosis in lung cancer patients. ZBTB2 N‐terminus‐mimetic polypeptides competitively inhibit ZBTB2 homodimerization and significantly suppress the ZBTB2–HIF‐1 axis, leading to antitumor effects. Our data reveal an important link between aberrant activation of hypoxia signaling and loss of a tumor suppressor and provide a rationale for targeting a key mediator, ZBTB2, to suppress cancer aggressiveness.
Adipose-derived stem/stromal cells (ASCs) as a potential treatment for chronic wounds in clinical conditions
Authors: Rybkowska Paulina
Published: November 2022

Treatment of hard-to-heal, chronic wounds, particularly in palliative patients or in intensive care units, constitutes a significant issue. Due to the constant development in this field of medicine and numerous scientific reports, it is possible to use a variety of techniques and dressings in the difficult-to-heal wound treatment. However, a promising strategy and an alternative to conventional dressings may be the transplantation of cell-coated bio-scaffolds into the wound. In addition to keratinocytes or fibroblasts transplants, which show promising healing effects during scarring, an interesting solution seems to be the use of multipotent mesenchymal stem/stromal cells, for instance, those derived from the adipose tissue (ASCs). Stem/stromal cell therapy presents a variety of benefits e.g., the isolation itself is simple, has minimal side effects, and any adipose tissue in an adult body may be the source of the cells. The presence of stem/stromal cells at the site of skin damage not only stimulates their proliferation or migration, but also their differentiation into other necessary cell types and continuous recovery at the site of a chronic wound. ASCs are also characterized by high paracrine activity, they are capable of secreting many growth factors, cytokines, and extracellular vehicles (EVs) to the external wound environment. They may also stimulate cell-to-cell interactions and improve the survival of resident cells. The multitude of mechanisms which can promote stem/stromal cells at the site of a chronic wound may potentially lead to more effective repair and regeneration processes and ultimately faster recovery. However, cell therapy requires detailed further research, in particular clinical trials, in order to assess the practicality and cost-effectiveness of this application in clinical environments and in hospital wards.
Replacing benzyl chloride with a lignin-degradation product in cellulose etherification decreases the melting point
Authors: Yahia Mohamed , Sundman Ola
Published: November 2022

A cellulose ether that is easier to melt than benzyl cellulose was produced from the lignin degradation product veratryl alcohol. Veratryl chloride and bromide were synthesized from the alcohol, and these two chemicals were used to react with Avicel® cellulose to form the novel cellulose ether veratryl cellulose (VC). Spectroscopic characterisation techniques (1H NMR, FTIR) indicated the successful conversion of Avicel® cellulose to the cellulose ether VC, by both routes, at a degree of substitution of 1.4 to 1.6. Melting measurements of the VC samples showed a gradual softening from approximately 110 °C; the VC was melted below 200 °C. XRD analysis confirmed that the chemical treatments affect the degree of crystallinity. Size exclusion chromatography results showed that the products differ remarkably in molecular weight. The VC synthesized with veratryl chloride degraded almost twice as much as when veratryl bromide were used. The cellulose ethers were soluble in DMSO, DMAc, and CHCl3.
Effect of vacuum and heat treatment on a single chain of cellulose: Molecular dynamics simulation
Authors: Wang Wei , Li Juncheng
Published: November 2022

Molecular dynamics simulation was used to better understand a single, non-crystalline cellulose molecular chain and its response to high-temperature treatment. The system temperature was varied from 430 K to 510 K, and the temperature interval was 20 K. Under the polymer consistent force field (PCFF), the dynamics simulation of each temperature was completed under the constant pressure/constant temperature dynamics (NPT). The experimental results showed that the mechanical properties of cellulose heat-treated at high temperature in a vacuum environment initially increased and then decreased with the increase of temperature. When the temperature was at 450 K, the mechanical properties reached an optimal state. Moreover, its mechanical properties were noticeably related to the connection of hydrogen bonds in the cellulose molecular chain and the thermal motion of the molecular chain.
Notes on Peruvian Ribes cuneifolium and Ribes ovalifolium (Grossulariaceae)
Authors: Maximilian Weigend , Andrade-Galán Ana
Published: November 2022

The genus Ribes (Grossulariaceae) is widespread across the northern hemisphere, but also species-rich in the tropical Andes. In the Peruvian Andes the genus is mostly found in at least seasonally moist cloud and scrub forests, subparamo habitats and hedges. However, some taxa are from more extreme habitats in semi-arid habitats of the western slope of the Andes (Andean scrub, Ribes ovalifolium) respectively high Andean puna and paramo habitats at elevations of up to 5100 m asl (Ribes cuneifolium and some doubtful segregates). These species share small, weakly divided leaves, making them quite atypical for the genus, usually with large, deeply three- to five-lobed leaves. Both the geographical ranges and the species delimitation for both taxa are poorly understood. We here propose the recognition of only two, well-differentiated species. Ribes ovalifolium can be shown to be wide-ranging from northern Ancash to Tacna, covering nearly the entire western flank of the Peruvian Andes. Similarly, Ribes cuneifolium can be shown to represent a single, wide-ranging species from high elevations of San Martín/La Libertad to Cuzco. There is considerable diversity on details of indument, flower color and leaf shape, but no clear dividing lines permitting the recognition of segregates such as Ribes incertum J.F.Macbr. The only exception are cloud-forest populations of Ribes cuneifolium in Pasco, which we propose to segregate as a new subspecies Ribes cuneifolium subsp. pascoense based on their considerably larger leaves and inflorescences.
The Impact of Metacognitive Reading Strategies on Master Students’ EFL Reading Proficiency and Academic Achievement
Authors: Levchyk Iryna , Chaikovska Hanna , Mazur Oksana , Adamska Zoriana , Zakordonets Nataliia
Published: November 2022

The paper investigates correlation of learners’ academic achievements with the application of metacognitive reading strategies (MRS) by the master students in EFL academic reading activities. The study was conducted in Ternopil Volodymyr Hnatiuk National Pedagogical University. Data was collected by means of focus groups interview and adapted scales of the MARSI questionnaire. The highlighted research is of a descriptive character; it has been completed with the aim of collecting the information at the initial stage of the experiment on master students’ usage of MRS in EFL academic reading activities.
E-Learning at the Tertiary Level in and After Pandemic
Authors: Holubnycha Liudmyla , Besarab Tetiana , Pavlishcheva Yana , Kadaner Oksana , Khodakovska Oksana
Published: November 2022

The article deals with new challengers in higher education system in terms of reality caused by coronavirus COVID-19. Some positive experience in English distance teaching and learning (at the basis of Yaroslav Mudryi National Law University, Ukraine) is described as it is significant in pandemic and may become useful for post pandemic society to improve educational processes. The purpose of the paper is to share positive ideas for English e-learning organization at the tertiary level in pandemic in order to use e-learning gains in further educational practice, highlight and solve its problems. General theoretical methods (analysis and synthesis) as well as empirical (observation and discussion) helped to find out advantages and identify disadvantages of the issue under study. The study has reached the following conclusions: asynchronous distance learning is effective for highly motivated students; synchronous forms demonstrate ability for developing all kinds of language skills. Advantages of distance teaching and learning there are: opportunity to display necessary didactic material on screen, to play audio recording or video materials for students in better quality. We have identified these problems: necessity of strong students’ motivation, connected with self-organization and the ability to work independently; sometimes insufficient technical skills of academic staff; academic dishonesty, which leads to meaninglessness of testing.
FEATURES OF THE LEGAL REGULATION OF URBAN-ECOLOGICAL RELATIONS DURING THE RUSSIAN-UKRAINIAN WAR
Authors:   State Organization “V. Mamutov Institute of Economic and Legal Research of NAS of Ukraine”, Kyiv, Ukraine, Kirin R.S.
Published: November 2022

The article is devoted to the analysis of the features of the legal regulation of urban-ecological relations during the russian-Ukrainian war (2014-2022). It has been revealed that the directions of development of the system of urban-ecological security, laid down in the current strategies of the national, sectorial, and regional levels, without taking into account the unprecedented military impact on the environment, should be considered rather fragmented and not fully in line with the European integration aspirations of Ukraine. It was revealed that the formation of the legal framework for urban-ecological relations at the level of individual cities and urban facilities took place before the start of full-scale aggression, mainly in areas related to water supply and water resources, protection of atmospheric air and historical monuments, land use, landscaping, urban monitoring, digitalization, cross-border cooperation. In the case of a techno- or anthropogenic impact, it is proposed to proceed from the presence of a composition of impact relations, in which the active action of the subject of influence (the subject of the origin of the impact) on the object of influence can have consequences for the subject of perception (the subject affected by the influence) through the object of perception. The prospects for the legal regulation of relations on compensation for environmental damage and damage caused by military influence, which are accompanied by a certain inconsistency, are given. In particular, after the adoption of relevant normative legal acts of a sub-legal nature, the question arose of consideration of laws on: 1) compensation for damage caused to the victim as a result of armed aggression, 2) legalization of loss calculation methods in accordance with internationally recognized ones, 3) the mechanism of confiscation of the property of the aggressor country in order to carry out work on the restoration of Ukraine, 4) digitalization of data on the damage caused and the profile of the victim.
ANALYSIS OF ORGANIZATIONAL AND ECONOMIC SUPPORT OF URBAN PARKS OF UKRAINE BASED ON POLLS
Authors:   State Organization “Institute of market and economic&ecological research of the National Academy of Sciences of Ukraine”, Odesa, Ukraine, Vernihorova N.V.
Published: November 2022

The development of comfortable urban parks is impossible without determining the priority needs and preferences of citizens. With the increasing pace of urbanization and the density of urban population, public green spaces must be designed to meet the needs of different categories and segments of the population. This is a difficult task, given the significant demand of urban parks, and the limited nature of their areas. Therefore, in order to increase the public and economic effects, the planning of park space must take into accountconsider the opinion of citizens. The purpose of this article is to present the results of sociological research in Ukraine on the satisfaction of the local parks and the formation of a universal and simple methodology of the questionnaire survey analysis. The research is based on the foreign experience of questioning the improvement of city parks and theoretical works of Ukrainian and foreign scientists on the importance of park space in cultural life. The accessibility of the questionnaire survey and its simple interpretation will allow in the future to introduce the survey in the practice of state and public institutions. The task of the questionnaire survey is to simplify the connection between state institutions and the public, to increase the level of mutual understanding and interaction. The following research methods were used in the article: questionnaire survey using electronic communication resources, analytical method and logical generalization. The questionnaire survey is constructed in such a way as to show the consumer potential of existing parks and consumer preferences of visitors. By comparing these characteristics in the analysis, you can understand how existing park facilities meet the needs of citizens. In the process of the questioning, there were revealed the problems of surveys in Ukraine, as well as some priority features of the needs of citizens in the use of parks for residents of large and small cities, the current problems in the improvement of green areas of the main categories of cities in Ukraine. In order to disseminate the experience of questionnaire surveys in the field of park improvement and to increase the popularity of this method of public relations, a universal method of assessing the results of the survey was proposed, which is acceptable in the evaluation of any questionnaire, easy to use and gives a clear understanding of the priority of certain areas. The work aims to embody an integrated approach to park improvement, in which green spaces are seen as important public space in cities, so they are designed and modernized with the participation of public opinion.
Formadoras da vida espiritual
Authors: Teixeira Patrícia Espíndola de Lima , Peretti Clélia
Published: November 2022

O artigo objetiva descrever o caminho de formação da vida espiritual através da obra de Teresa D’Ávila (1515-1582) discutida por Edith Stein (1891-1942) no ensaio O Castelo Interior (Die Seelenburg). A fenomenóloga, a partir de seus estudos sobre a Empatia (Zum Problem der Einfühlung), desenvolveu uma antropologia de inteireza humana, corpo-psique-espírito (Leib), afirmando a existência de um “núcleo pessoal” (Kern) de natureza espiritual. No fluxo de suas pesquisas, conheceu os escritos cristãos. Estes ampliaram suas bases teóricas em aliança com as pesquisas que desenvolvia. O texto delimita-se no impacto dos escritos de Teresa D’Ávila na vida e obra de Edith Stein. Ao conhecer o Livro da Vida (1563), a filósofa decide (re)examinar sua trajetória, convertendo-se ao Cristianismo Católico e expandindo seus estudos fenomenológicos à antropologia teológica. Por este caminho, através do método de análise bibliográfica e documental, revisita-se a literatura de Edith Stein com Teresa D’Ávila, mapeando as contribuições de ambas como formadoras do humano ao conhecimento do mistério de Deus e da experiência de um Deus-Amor habitante na interioridade espiritual. Conclui-se com interfaces paradigmáticas através da educação do espírito em inteireza com a formação da pessoalidade e com as relações comunitárias, educação esta cada vez mais urgente frente as complexidades e fragmentações hodiernas.
A infopastoral como caminho para a interlocução entre o Evangelho e a cultura digital
Authors: Gripp Andréia , Martins Mario Roberto de Mesquita
Published: November 2022

A cultura digital representa nos tempos hodiernos um desafio para o ser e o agir da Igreja: para cumprir sua missão de anunciar a mensagem do Evangelho a toda criatura (Mc 16,15), ela precisa habitar a “infosfera” (uma evolução dos conceitos “continente digital” e “ciberespaço”) e realizar a infopastoral. As novas tecnologias geram uma mudança na forma como nos relacionamos em sociedade e criam padrões de comportamentos complexos que moldam o ser humano, inserido em uma dinâmica de vida “onlife”. A pandemia de COVID-19 explicitou essa realidade, trazendo-nos, de forma inesperada, o que se considerava “o futuro”. A necessidade do distanciamento social levou a Igreja a utilizar mais amplamente as tecnologias digitais para manter a unidade pastoral e possibilitar aos fiéis a continuidade da experiência da fé, agora em novo ambiente, não físico. A partir da pesquisa e análise bibliográficas, do magistério do Papa Francisco, de autores e pesquisadores da Teologia, da Comunicação, da Sociologia e da Tecnologia, este artigo pretende apresentar perspectivas para uma pastoral na sociedade da informação. A questão norteadora desta reflexão é a interlocução entre o Evangelho e a cultura digital. Concluímos que, para que essa interlocução aconteça, faz-se necessário iniciar um processo de conversão pastoral, com reconhecimento da cultura digital, aprendizado de sua linguagem e corresponsabilidade evangelizadora de todo o povo de Deus.
Associações entre autocompaixão e esquemas iniciais desadaptativos
Authors: Pfeiffer Sandiléia , Pureza Juliana da Rosa
Published: November 2022

Apesar das repetidas relações entre autocompaixão e saúde mental e a relevância dos esquemas iniciais desadaptativos (EID’s) para compreensão do funcionamento da personalidade, ainda é internacionalmente escasso o número de estudos que relacionam tais construtos. O objetivo deste estudo foi investigar as relações entre os componentes da autocompaixão e os EID’s. A amostra foi composta por 328 estudantes universitários, com idade média de 25,39 (DP=6,99). Como instrumentos, foram utilizados a Escala de Autocompaixão de Neff (SCS) e o Questionário de Esquemas de Young (YSQ-S3). Os resultados mostraram correlações negativas e significativas entre os EID’s e os componentes da autocompaixão, sugerindo que quanto maior a intensidade do esquema, menores os níveis de autocompaixão. Compreender a forma como as características individuais se relacionam com os componentes da autocompaixão pode nortear o desenvolvimento de intervenções mais apuradas para a promoção dos benefícios da autocompaixão.
Usability Evaluation of Brain Computer Interfaces: Analysis of State of Art
Authors: Ortega-Gijón Yoselyn Nohemí , Mezura-Godoy Carmen
Published: November 2022

Brain Computer Interfaces – BCI allow users to communicate with the software system through cognitive functions measurable by brain signals, identified as Electroencephalography – EEG. User tests have been the most used method for usability evaluation of BCI software applications. In user tests, the data collected comes from the opinions of users through questionnaires, these tests require a lot of time, since they include not only performing interaction task and the application of the questionnaires, but also include placing and calibrating the EEG device. All this makes the evaluation process a very heavy task for the participants of the test and can mean that the data collected is not entirely reliable. That is why we are interested in including EEG signals in the usability evaluation process of applications with BCI software applications. Therefore, we present in this paper the result of the analysis of state of art in order to identify the relevant works in the area and future lines of research.
Implementation of distributed and parallel computing in the SDN network
Authors: Burdonov Igor Borisovich , Yevtushenko Nina Vladimirovna , Kossatchev Alexander Sergeevitch
Published: November 2022

The paper discusses the execution of a program of tasks on the SDN data plane, modeled by a finite connected undirected graph of physical connections; the execution is understood in the sense of the object-oriented programming paradigm as consisting of objects and messages that objects can exchange. Objects are implemented in hosts. Several different objects can be implemented in one host and the same object can be implemented in several hosts. Messages between objects implemented in different hosts are transmitted in packets which are routed by switches based on identifiers assigned to packets that is on a set of values of some packet parameters in the packet header. Two problems are tackled in the work: 1) minimizing the number of identifiers, 2) setting up switches to implement the paths that packets should take place. These tasks are solved in two cases: A) a packet intended for some object must get into exactly one host in which this object is implemented, B) a packet can get into several hosts, but the desired object must be implemented in one and only one of them. It is shown that problem 1 in case A is equivalent to the set covering problem, and the minimum number of identifiers in the worst case is min{ n, m } where n is the number of objects, and m is the number of hosts implementing objects. In case B, the problem is a special modification of the set covering problem, the hypothesis is proposed that the minimum number of identifiers in the worst case is min{ ëlb(n + 1)û, m }. So far, an upper bound is O( min { ln (min { n, m }) × ln ( n, m ) } ). To solve problem 2 in cases A and B, algorithms for switches’ setting are proposed which have the complexityO( m ) and O( k m ), , respectively, where m is the number of the edges of the graph of physical connections and k is the number of the required packet identifiers.
Organization of a secure query to a database in the cloud
Authors: Martishin Sergey Anatolievich , Khrapchenko Marina Valerievna , Shokurov Alexander Vladimirovich
Published: November 2022

The development of cloud computing, including the storage and processing of confidential user data on servers that can be attacked, puts forward new requirements for information protection. The article explores the problem of obtaining information from the database by the client in such a way that no one except the client himself get any information about the information the client is interested in (PIR - Private Information Retrieval). The problem was introduced in 1995 by Chor, Goldreich, Kushilevitz and Sudan in the information-theoretic setting. A model of cloud computing is proposed. It includes a cloud, a user, clients, a trusted dealer, a passive adversary in the cloud. Also, the attacking side has the ability to create fake clients to generate an unlimited number of requests. An algorithm for the organization and database distribution on the cloud and an algorithm for obtaining the required bit were proposed. Communication complexity of the algorithm was estimated. The probability of revealing required bit's number in the case when fake clients perform unlimited requests was estimated too.
Unified type system for the modern general-purpose programing language
Authors: Kanatov Alexey Valer’evich , Zouev Eugene
Published: November 2022

The paper presents an overview of the type system, which supports the convergence of procedural, object-oriented, functional, and concurrent programming paradigms relying on static type checking with smart type inference support and the ability to ensure dynamic type safety as well. The key element of the type system is that it is fully based on just 2 basis constants and all other constructions are derived.
Diff tool for comparing .NET assemblies in the Rider IDE
Authors: Miroshnikov Vladislav Igorevich
Published: November 2022

A .NET developer occasionally needs to compare compiled programs or assemblies, e.g., when updating versions of third-party libraries or when working with their own binary files. However, the existing tools have some significant drawbacks, for example they don't support comparison of .NET Core assemblies. In this paper we reviewed different types of .NET assemblies and, taking into account their structure, developed and integrated into Rider IDE our own Assembly Diff tool which considers the disadvantages of the existing tools and expands the comparison possibilities. We presented several variants of comparison tool presentation and implementation and chose the most functional one in the form of a comparison tree, for which we developed and described special algorithms allowing to take into account semantic features of .NET types.
Modified Error Detection and Localization in the Residue Number System
Authors: Gladkov Andrei Vladimirovich , Kuchukov Viktor Andreevich , Babenko Mikhail Grigoryevich , Tchernykh Andrei Nikolaevitch , Berezhnoy Victor Vasilyevich , Drozdov Alexander Yulievich
Published: November 2022

This article presents the design of the modified error detection and localization algorithm in the Residue Number System (RNS). Classical redundant RNS with one control modulus can detect one error but not localize it. Two control moduli are used to localize a single error. Presented algorithm can achieve an error correction with a single control modulus transmitted over a reliable communication channel. The proposed approach was verified using Verilog on ASIC in RTL and physical synthesis tool Cadence Genus Synthesis Solution. It significantly reduces the area of the hardware implementation increasing the packing density and more efficient use of silicon resource. It slightly increases the running time compared with the classical algorithm. Distributed data storage was developed to study efficiency of the proposed algorithm.
Mobile Learning Platform focused on Learning Monitoring and Customization: Usability Evaluation Based on a Laboratory Study
Authors: Ángel-Flores Herminio Del , López-Domínguez Eduardo , Hernández-Velázquez Yesenia , Domínguez-Isidro Saúl , Medina-Nieto María Auxilio , De La Calleja Jorge
Published: November 2022

The learning customization and monitoring are considered key aspects of the teaching-learning processes. Some works have proposed mobile learning systems that provide teachers and students learning monitoring and personalization services. One of the main requirements of these kinds of systems in terms of software quality is usability; however, few works have addressed the usability issues using laboratory studies with users in real domains. In this work, we present a usability evaluation of the learning monitoring and personalization services of a mobile learning platform based on a laboratory study in which nine teachers and ten students participated. In our usability evaluation, the aspects evaluated were effectiveness, efficiency, and level of user satisfaction as proposed by the ISO/IEC 25000 family of standards. The results show that the teachers presented effectiveness, efficiency, and satisfaction considered satisfactory, while the students presented effectiveness and satisfaction classified as satisfactory and acceptable efficiency. The usability evaluation described in this work can serve as a reference for developers seeking to improve learning monitoring and personalization services development.
Model-Driven in Serios Games and Serious Games with User-Centered Design in the Last Decade: A Review
Authors: Silva-Vásquez Pedro Omar , Rosales-Morale Viviana Yarel , Benítez-Guerrero Edgard
Published: November 2022

This paper reviews the literature on automatic code generation of user-centered serious games. We decided to break the study in two parts: one study about serious games with model driven engineering, and another study about user-centered serious games. This paper presents an extension of a paper presented at CONISOFT 20 where a systematic review of 5 years old at the time of writing was presented exclusively. The systematic literature review conducted in this paper covers a decade of information from January 2012 to June 2022. The main objective is to know the literature that helps to mitigate the costs and time of software development in serious games. The overall conclusion is that there is still work to be done to combine serious user-centered games and automatic generation. This paper is a systematic review that identifies relevant publications and provides an overview of research areas and publication venues. In addition, Research perspectives were classified according to common objectives, techniques, and approaches. Finally, is presented point out challenges and opportunities for future research and development.
Depth of Cure, Mechanical Properties and Morphology of Dual-Cure Bulk-Fill Composites
Authors: Sarialioglu Gungor Ayca , Durmus Ali , Zengin Kurt Belma , Köymen Safiye Selin , Dönmez Nazmiye
Published: November 2022

This study evaluated selected structural and physical properties, such as degree of conversion (DC), Vickers hardness (VHN), and compression strength (CS), of three new dual-cure bulk-fill resin-based composites (RBCs; ACTIVA, HyperFIL, and Fill-Up) and compared them to those of a conventional RBC (Filtek Z250) at three clinically relevant depths. Samples (n=180) were prepared in three depths (2,4, and 6mm). Fourier-transform infrared spectroscopy (FTIR) analysis and VHN and CS tests were performed. The DC value was calculated by considering the relative change in the aliphatic C=C peaks. The fractured surfaces of representative samples were characterized using scanning electron microscopy (SEM). Data were statistically evaluated using two-way analysis of variance and post hoc Bonferroni tests (p<0.05). According to the VHN results, Filtek Z250 showed the highest bottom/top hardness ratio (97.94±1.01) at 2mm thickness and ACTIVA showed the lowest bottom/top hardness ratio (43.48±5.64) at 6mm thickness (p<0.001). According to the FTIR results, the DC decreased with increasing thickness in all materials (p<0.05). Filtek Z250 showed the highest (301±12.4 MPa) and ACTIVA exhibited the lowest (232±17.2 MPa) CS values at 2mm thickness (p<0.05). The lowest CS values were obtained for ACTIVA, and the highest values were obtained for Filtek Z250 for samples with thicknesses of 4 and 6mm, respectively (p<0.05). The structural features of restorative composites, such as the resin chemistry and filler type and content, and the operational parameters (i.e., material thickness and curing conditions) strongly affect crosslinking reactions and thus the DC, VHN, and CS values.
Acute Osteomyelitis in Torus of Systemically Compromised Patients: Case Series
Authors: Boza-Oreamuno Yadira V. , López-Soto Andrea
Published: November 2022

The torus are benign bony prominences that generally do not require treatment, however, they can occasionally present osteomyelitis (OM). The objective of this article is to describe the timely management of torus osteomyelitis through a series of clinical cases. Three patients with OM are reported. Two cases of men aged 66 and 69, diabetics, as well as a 57-year-old woman with a history of basal cell carcinoma of the nose. All had torus ulcers associated with trauma and without resolution of the same. In the three cases, a biopsy was performed to confirm the diagnosis and they were treated with anti-inflammatory drugs and antibiotic therapy, achieving complete resolution. Uncontrolled diabetes mellitus and trauma can favor the development of OM in patients with bone exostoses, therefore, when there are signs of infection in these structures, it is imperative to suspect the condition and offer treatment.
Some notes on the interpretation of chapter 11 of the lex Troesmensium and chapter G (45) of the lex Irnitana
Authors: Illés Imre Áron
Published: November 2022

The present article offers some reflections on Werner Eck's translation and interpretation of chapter 11 of the lex Troesmensium regulating the municipal embassies: (1) not the future, but the former magistrates were forbidden to be ambassadors; (2) not the ordo decurionum, but the duumvir sent the ambassadors – according to the decision of the decurions, of course; and (3) the future ambassador had to be informed not five days after the decision, but five days before the departure.
Pet goods consumption in Polish households
Authors: Gromek Natalia , Perek-Białas Jolanta
Published: November 2022

This paper expands the considerations of Becker’s and Leibenstein’s family theories with a focus on the additional member of the household (pet/animal) in the analysis of consumption. It is the first analytical approach regarding pet goods consumption with references to microeconomic theories based on Polish data. The study analyses the households’ characteristics that have an impact on expenditure on pet goods. This article used the Polish Household Budget Surveys for 2018. The findings from the logistic regression models suggest that the household’s socio-economic group, place of living, children in household and whether the household rents the flat/accommodation impact on determining the probability of owning a pet among Polish house-holds; analyses of interactions between significant variables were also conducted. However, the human-animal bond could not be included in analysis, which is a limitation, the overall work is pioneering, as it shows the quantitative approach to household economy that highlights the need to elaborate the economic family theories of Becker and Leibenstein by a new family member – a pet.This paper expands the considerations of Becker’s and Leibenstein’s family theories with a focus on the additional member of the household (pet/animal) in the analysis of consumption. It is the first analytical approach regarding pet goods consumption with references to microeconomic theories based on Polish data. The study analyses the households’ characteristics that have an impact on expenditure on pet goods. This article used the Polish Household Budget Surveys for 2018. The findings from the logistic regression models suggest that the household’s socio-economic group, place of living, children in household and whether the household rents the flat/accommodation impact on determining the probability of owning a pet among Polish house-holds; analyses of interactions between significant variables were also conducted. However, the human-animal bond could not be included in analysis, which is a limitation, the overall work is pioneering, as it shows the quantitative approach to household economy that highlights the need to elaborate the economic family theories of Becker and Leibenstein by a new family member – a pet.