bluuebunny/crossref_metadata_2025 huggingface dataset:
Coproporfiria hereditaria
Authors: Hurtado Mayor Jorge Andrés , Castro Henao Juliana , Salazar Cuevas María Camila , Barrios Arroyave Freddy Andrés , Duque Arias Mónica
Published: December 2021

La coproporfiria hereditaria (CPH) es un trastorno congénito, autosómico dominante, que se presenta en aproximadamente dos a cinco personas por cada millón de habitantes a nivel mundial. Constituye un reto diagnóstico en aquellos pacientes que cursan con dolor abdominal agudo. Se presenta el caso de una adolescente de 17 años que debutó con un cuadro atípico de dolor abdominal sin etiología clara. Se le documentó porfobilinógeno elevado en orina y fue tratada con hematina. El estudio genético realizado concluyó condición de portadora hererocigota de la variante nonsense patogénica c.717T>A; p.Cys239 en el gen CPOX, permitiendo diagnosticar una coproporfiria hereditaria. La literatura nacional disponible ha presentado casos con diagnóstico de porfiria aguda intermitente en pacientes con dolor abdominal de origen no específico, sin abordar las clasificaciones existentes de las porfirias hepáticas y sin detallar el diagnóstico genético, por lo cual el presente caso es un aporte a la casuística nacional
Es hora de adaptar la definición de la enfermedad renal crónica de acuerdo con la edad
Authors: Nieto-Ríos Jhon Fredy , Zuluaga Quintero Mónica , Ariza-Parra Edwin Jesús , Bello-Márquez Diana Carolina , Gómez-Castro Laura Tatiana
Published: December 2021

La enfermedad renal crónica es una condición con alta morbilidad, mortalidad y costos elevados para los sistemas de salud que afecta todos los grupos de población con impacto significativo en su calidad de vida. Su clasificación ha sido modificada con el tiempo y aún no existe un consenso universal para diferenciar un cambio fisiológico del aclaramiento renal versus patológico. A continuación, se expone la importancia de replantear la definición y clasificación en la población general de acuerdo a la edad, incluyendo a niños y adultos.
Pendampingan Pembuatan Krupuk Berbahan Baku Susu Sapi Perah di Desa Samar Kecamatan Pagerwojo Kabupaten Tulungagung
Authors: Laily Purnawati  , Nunun Nurhajati
Published: December 2021

Desa Samar yang berada di wilayah Kecamatan Pagerwojo memiliki potensi peternakan sapi perah. Masyarakat di didaerah menggantungkan hidupnya dari beternak sapi perah (60% dari jumlah penduduk). Hal ini merupakan keuntungan tersendiri karena selain bisa meningkatkan kesejahteraan masyarakat juga bisa dimanfaatkan susu segarnya bagi kesehatan warganya. Permasalahan yang dihadapi pertama, bagaimana memanfaatkan hasil produksi susu sapi yang tidak tertampung di KUD menjadi bahan olahan yang mempunyai nilai ekonomi dan tidak mengalami kerugian sehingga peternak sapi perah tetap bertahan. Dilain sisi, istri peternak selama ini hanya sebagai ibu rumah tangga yang tidak produktif secara ekonomi sehingga perlu upaya agar istri peternak ini bisa berdaya secara ekonomi juga. Kedua, bagaimana meningkatkan ketrampilan istri peternak memanfaatkan susu sapi perah menjadi bahan baku olahan krecek dan krupuk susu.

Solusi yang ditawarkan, pertama pembuatan krecek dan krupuk susu dengan sensasi varian rasa berbahan baku susu sapi perah. Kedua, peningkatan kualitas SDM melalui pelatihan-pelatihan pada aspek produksi dan pemasaran berbasis IT (website, marketplace, media sosial). Metode kegiatan yang dilaksanakan dengan cara melakukan observasi dan pendekatan kepada peternak sapi perah, kelompok perempuan, dan pemangku kepentingan. Dimana masyarakat dilibatkan dalam berbagai tahapan kegiatan mulai dari sosialisasi, perencanaan, pelaksanaan dan evaluasi. Target luaran yang diharapkan adalah publikasi ilmiah, buku ajar dan produk.
Strategi Pemulihan Ekonomi melalui Sinergi Pemasaran Digital “LapakUMKM.Com”
Authors: Eni Widhajati  , Efriza Pahlevi Wulandari
Published: December 2021

Covid-19 menimbulkan berbagai permasalahan bagi UMKM di Tulungagung Jumlah UMKM di Tulungagung sebanyak 129.173 yang didominasi oleh usaha mikro dan lebih dari 60 persen terdampak covid-19 seperti penurunan omset penjualan, kebutuhan modal, terhambatnya distribusi, sulitnya akses bahan baku, dan produksi menurun.    Di sisi lain ada kesempatan yang juga muncul yaitu pelaku UMKM bisa memanfaatkan teknologi informasi dan komunikasi. Dari permasalahan tersebut maka solusi yang akan diberikan adalah dengan melakukan strategi pemulihan ekonomi melalui sinergi berbagai pihak melalui platform pemasaran digital “Lapakumkm.com”. Dengan adanya lapakumkm.com sangat membantu dalam pemberdayaan UMKM di Kabupaten Tulungagung, terlebih dalam menghadapi pandemic covid-19 ini. Inilah yang menjadi salah satu pintu UMKM untuk meningkatkan laba penjualan, membangun strategi, serta memperluas akses pemasaran secara online. Pemerintah melalui Dinas yang membidangi UMKM mendukung sepenuhnya dengan penyediaan akses digital marketing dan sinergitas para pihak terkait kepada pelaku UMKM melalui platform digital lapakumkm.com.
The Earnings Difference of Workers in Indonesia: 2007 and 2014
Authors: Prabowo Aryo
Published: December 2021

The purposes of this study are to measure the earnings difference and the factors that influence earnings difference between 2007 and 2014 using data sourced from the Indonesian Family Life Survey (IFLS) in 2007 and 2014. The income determinant analysis results found that the longer a person's education year and work experience, the higher the income. Income will be even greater if someone is a man, lives in urban areas, and works in the non-agriculture sector. Moreover, there is no evidence that religion and ethnicity affect income. Then, I used the Blinder-Oaxaca decomposition method to distinguish the factors contributing to the difference in income to be explained factors and unexplained factors. It was found that that the income gap between 2007 and 2014 was 13.2 percentage points. Endowment factor contribution is more significant than unexplained factors. Furthermore, decomposition at different income levels shows that the endowment factor's effect on earning difference is getting smaller at higher income levels.
The Impact of Biogas Utilization on Poverty in Indonesia
Authors: Hartono Djoni , Maharani Jayanti
Published: December 2021

The provision of reliable, adequate, and sustainable energy services has been a global challenge until today. Without the availability of energy, particularly for cooking and lighting, leads to difficulties in achieving the expected quality of life, mainly for underprivileged people who have not met the minimum standard of living. In order to fulfill the necessity of energy, new renewable energy sources are needed, one of which is through biogas installations. The purpose of this study was to find empirical evidence related to the impact of biogas utilization on poverty, especially in rural areas, by transforming the number of underprivileged people in an area. Through Village Potential (Potensi Desa/Podes) data 2008 – 2018, Biogas development from the Ministry of Energy and Mineral Resources in 2011-2017, and using the difference-in-differences (DID) method, it is expected that this study might contribute to the literature, especially related to energy, with comprehensive results. This study detected that after the implementation of biogas installation program, the number of beneficiaries of health insurance programs in villages with biogas installations decreased by 136 people compared to villages without biogas.
THE EFFECTIVENESS OF AGGREGATION OF THE DRUG DERINAT IN THE COMPLEX TREATMENT OF ARVI IN PRESCHOOL CHILDREN IN THE PRACTICE OF THE DISTRICT PEDIATRICIAN
Authors: Зуйкова Анна Александровна , Красноруцкая Ольга Николаевна , Котова Юлия Александровна , Бугримов Даниил Юрьевич
Published: December 2021

Острые респираторные вирусные инфекции (ОРВИ) представляют собой серьезную проблему для общественного здравоохранения во всем мире, вызывая значительную заболеваемость и смертность среди людей всех возрастных групп. Дети заражаются в среднем в два-три раза чаще, чем взрослые. Целью исследования является оценка эффективности препарата Деринат в комплексном лечении острых респираторных вирусных инфекций у детей дошкольного возраста в условиях амбулаторно-поликлинического приема. В исследование были включены дети в возрасте от 3 до 7 лет (включительно) не являющиеся школьниками, с клиническим диагнозом острая респираторная вирусная инфекция (ОРВИ), с симптомами, проявляющимися не длительнее 48 часов, не подвергавшихся противовирусной и иммуномодулирующей терапией в течение 30 дней до текущего посещения врача. В результате проведенного исследования установлено, что комплексное лечение ОРВИ у детей дошкольного возраста с применением препарата Деринат с первого дня терапии позволяет устранить отдельные симптомы ОРВИ значительно быстрее и эффективнее, чем при стандартных схемах терапии: ринорея и заложенность носа купируется на 2 день терапии, а гиперемия ротоглотки и отечность миндалин - на 3 день. Назначение изучаемого препарата в комплексном лечении ОРВИ в 2,4 раза повышает «Индекс здоровья» у дошкольников по сравнению с показателем при стандартных схемах лечения

Acute respiratory viral infections are a serious public health problem worldwide, causing significant morbidity and mortality among people of all age groups. Children are infected on average two to three times more often than adults. The aim of the study is to evaluate the effectiveness of the drug Derinat in the complex treatment of acute respiratory viral infections in preschool children in outpatient settings. The study included children aged 3 to 7 years (inclusive) who are not schoolchildren, with a clinical diagnosis of acute respiratory viral infection, with symptoms that manifest no longer than 48 hours, who were not subjected to antiviral and immunomodulatory therapy for 30 days before the current doctor's visit. As a result of the study, it was found that the complex treatment of acute respiratory viral infections in preschool children with the use of the drug Derinat from the first day of therapy can eliminate individual symptoms of ARVI much faster and more effectively than with standard therapy regimens: rhinorrhea and nasal congestion are stopped on day 2 of therapy, and oropharyngeal hyperemia and tonsillar edema - on day 3. The administration of the studied drug in the complex treatment of acute respiratory viral infections increases the "Health Index" in preschool children by 2.4 times compared to the indicator for standard treatment regimens
Use of structural materials in the automotive industry
Authors: Grushnikov V.А.
Published: December 2021

Competitive and environmental aspects of improving designs and manufacturing processes for both components and complete cars and trucks force their manufacturers to look for optimal solutions for the choice of materials and methods of their processing, and the supplier of the materials themselves — according to their structural properties and characteristics of mechanical processing or shaping.

Keywords: vehicles, components, manufacturing processes, research, construction materials
Determination of factors of operational technical readiness and ageing of roadbuilding machines
Authors: Grushetskiy S.M.
Published: December 2021

The purpose of this article is to show how in practice it is possible to determine the actual rate of operational technical readiness of road construction machines in three different ways. This will allow you to compare them and give them an assessment. It is well known that in practice, with an increase in the life of road construction machines, their production time decreases. This is due to such a phenomenon as the aging of road construction machines. In this article, the actual ageing factor of road construction machines will still be determined.

Keywords: road construction machines, technical readiness coefficient, operational technical readiness coefficient, ageing coefficient
Improving the fuel supply system of the vehicle
Authors:   Mukhametdinov E.M. Galyishev YU.V. Gabsalikhova L.M. Kashapov R.R. Popov K.S.
Published: December 2021

Today, one of the urgent problems of car operation is the problem of fuel overheating at elevated ambient temperatures, resulting in an error " fuel overheating" on the car, which in turn affects the car’s performance. This article presents research on testing fuel heat exchangers as part of a car’s fuel system by improving the design of the car’s power system. Three experiments were carried out to determine the temperature regime of the vehicle’s power supply system. Positive results of the work were obtained, which made it possible to eliminate the occurrence of the error " fuel overheating" and obtain stabilization of the fuel temperature.

Keywords: power system, heat exchanger, cooling
Naskah-Naskah Karya K.H. Ahmad Rifa'i Kalisalak di Kabupaten Wonosobo
Authors: Noviani Nur Laili , Maknun Moch. Lukluil , Iswanto Agus , Ruchani Bisri
Published: December 2021

K.H. Ahmad Rifa’I is one of the scholars in Indonesia who until now has loyal followers and spreads in various regions. One of the da'wah that he taught was to write religious books. The manuscript is still used by the congregation. One of the storage areas for manuscripts by K.H. Ahmad Rifa’i is in Wonosobo, at the house of K.H. Amin Ridlo (Rifa’iyah figure). Some of the manuscripts are thought to have not been disclosed. This study aims to reveal the manuscripts of K.H. Ahmad Rifa’i Kalisalak in Wonosobo kept by K.H. Amen Ridlo. This qualitative descriptive research was carried out with inventory and transmedia activities of the manuscript. Based on the data collection, there were 14 manuscripts by K.H. Ahmad Rifa’i and also the work of his students that have been successfully transferred to the media. These manuscripts contain various titles and themes, and some of them are in accordance with the inventory list that has been compiled by the Rifa’iyah organization.
Microbiological
quality of well water from Koprivnica-Križevci County in 2018
Authors: Furmeg Sanja , Feher Turković Lana , Mojsović-Ćuić Ana , Jaki Tkalec Vesna , Kiš Maja
Published: December 2021

In this study, microbiological quality of drinking water deriving from the private wells from Koprivnica-Križevci County was investigated. A total of 287 samples from different locations were collected during 2018 and analysed for the following microbiological parameters: total coliforms, Escherichia coli, Enterococcus spp., Clostridium perfringens, Pseudomonas aeruginosa, and the number of aerobic heterotrophic bacteria at 36 °C and 22 °C. The results showed that 24 % of the analysed water samples were of unsatisfactory microbiological quality, with high incidence of faecal contamination. Well water is still the main source of drinking water for many residents of this County, especially in its rural parts, so continuous monitoring and disinfection of drinking water deriving from private wells is of exceptional importance for the public health.
Dependence
of concentration of radon on environmental parameters
Authors: Ptiček Siročić Anita , Kovač Sanja , Stanko Davor , Pejak Iva
Published: December 2021

Radon (222Ra) is a colourless and odourless natural radioactive element in gaseous state. The concentration of radon in the air is usually low, but it can be very high inside of a living space, because of its possibility to penetrate from a foundation soil over a basement into a building itself. People are daily exposed to a certain concentration of radon that is found in soil, water, air and food. This paper shows a correlation analysis of environmental parameters by using the model of multiple regressions. It defines certain statistical relations between environmental parameters such as temperature, humidity, and atmospheric pressure with measured values of radon concentrations. Measurements were carried out at several locations in various residential buildings in north-western Croatia. The results indicated that individual environmental parameters and radon concentration at individual locations were connected. For example, at one location the concentration of radon was decreasing if atmospheric pressure was increasing. Measurements at another location indicated that the concentration of radon was increasing if air humidity was increasing. Due to large number of different parameters affecting the concentration of radon in residential buildings, a satisfactory statistical model to predict the concentration of radon with environmental parameters is not easy to achieve since it was observed variability of radon concentrations with environmental parameters within different local sites. It is necessary to consider a longer period to determine with certainty a mathematical model that would give the most accurate prediction of radon concentration dependence on environmental parameters which can affect human health and quality of life.
Influence of
leachates on geotehnical and geochemical properties of termite mound soils
Authors: Adekunle Adebola , Nkeshita Fidelis , Akinsanya Adetayo
Published: December 2021

This
study investigated the influence of leachate prepared from Telfairia
occidentalis on the geotechnical and geochemical properties of termite mound
soil obtained from the premises of the federal university of agriculture,
Abeokuta, south-western Nigeria. The termite mound soil samples were collected
from three different locations and each sample collected was contaminated by
mixing with leachates in percentage increments of 0% 10%, 15% and 20% of dry
weight of the air-dried soil. The soil samples were subjected to Atterberg
limits and hydraulic conductivity tests for geotechnical observation and X-ray
fluorescence tests for geochemical tests. The range of values for the
geotechnical analyses were obtained as; plastic limit (9.1% – 14.2%), liquid
limit (28.6 % – 61%), plasticity index ((18.2% – 49.5%) and hydraulic
conductivity (1.85 – 4.1 x 10-8) cm/sec) with a resultant reduction
in the plastic limit, liquid limit and plasticity index values but an increase
in the hydraulic conductivity of the samples as the leachate concentration
increased. The results from X-ray fluorescence analyses after 20% leachate
contamination showed that the major elemental chemical composition for the
three samples were comprised of SiO2 (56.25 – 56.5%), Al2O3
(28.42 – 28.50%), Fe2O3 (4.46 – 6.5%), TiO2
(1.08 – 1.23%), CaO (1.45 – 1.60%), P2O5 (0 – 0.04%), K2O
(0.9 – 6.1%) and MnO (0.02 – 4.7%). There was a marginal alteration of the
indices with the values inferring the presence of a minimum composition of
feldspar and a major composition of quartz-rich minerals and thus lending more
credence to the presence of silicates as shown from the X-ray fluorescence
results. It also infers that the termite mounds are predominantly made from
sand materials. The termite soil samples obtained from the aforementioned
locations may not be suitable for engineering works unless stabilization
procedure is adopted.
Influence of
shear rate on the soil's shear strength
Authors: Bek Anja , Jeftić Goran , Strelec Stjepan , Jug Jasmin
Published: December 2021

One of the most important mechanical properties is shear strength. It is conditioned by the value of the maximum shear stress that the soil can withstand before failure. Exceeding the shear strength causes one particle to slide next to another, causing the failure of soil. The shear strength of the soil for effective stresses is1 a combination of drained strength parameters: internal friction angle (φ) and cohesion (c) defined by the Mohr-Coulomb failure criterion. It is determined “in situ” and by laboratory experiments. Direct shear is the oldest and the simplest laboratory experiment to determine the shear strength of the soil. The first phase of experiment is specimen consolidation under specific vertical stress, and in the second phase specimens are sheared at a given shear rate, depending on the consolidation properties of the soil. Cohesionless soils are sheared at up to 100 times higher shear rate compared to cohesive soils. Shear rate and drainage conditions affect the magnitude of soil strength parameters. The paper is based on the comparison and demonstration of the influence of different shear rates on the peak and residual shear strength in the direct shear device. The tests were performed on two samples of low plasticity clay (CL) and one sample of high plasticity clay (CH).
Мультикультурний підхід до професійної підготовки фахівців у закладі вищої освіти
Authors: Бучковська Олена , Веремчук Олена
Published: December 2021

Стаття присвячена проблемі мультикультурної освіти, що стала глобальною необхідністю, спеціалізованою формою навчання, котра ґрунтується на позиціях рівності, плюралізму, визнання та прийняття різноманіття соціокультурного середовища. Мультикультурний підхід до вищої освіти вимагає переосмислення сутності та переформатування змісту навчального процесу. Культурна стратегія розвитку закладів вищої освіти має бути орієнтованою на організацію мультикультурного освітнього середовища, у якому відбувається формування мультикультурної особистості студента. Включення дисциплін мультикультурного дискурсу дозволить набувачам вищої освіти здобути знання щодо моральних цінностей інших культур, розширити можливості професійного зростання та отримання досвіду в інших країнах. Мультикультурна освіта у статті розглядається як об’єктивна потреба сучасного суспільства у підготовці культурно-компетентнісного фахівця, який поряд з академічними та професійними знаннями повинен отримувати знання та навички міжкультурних взаємовідносин, культурного плюралізму, здатності жити та працювати у культурно різноманітних суспільствах.
Metafizika biblioteke = Metaphysics of the Library
Authors: Kulenović Emira
Published: December 2021

Bibliotekarstvo kao nauka i vještina organizacije znanja i njegovih produkata evoluira te je, kao i sve ostale naučne ili praktične discipline, prisiljeno prilagođavati se vremenu. Na tom svom evolucijskom putu, općeprihvaćene teorije i poimanje biblioteke i bibliotekarstva kao struke se mijenjaju te se sve više udaljavaju od tradicionalnih predstava – gotovo do granice naučne fantastike. Pa ipak, do juče fikcijske, književnoumjetničke predstave, danas se posmatraju na krajnje konstruktivan i racionalan način. Jedan od najzanimljivijih primjera je doživljaj i vizija biblioteke u fikcijskom svijetu Jorgea Luisa Borgesa. Na tragu njegovih profetskih zapažanja utkanih u njegov književni univerzum, mnogi naučnici današnjice iz različitih oblasti kroz multidisciplinarni pristup pokušavaju rekonstruirati i kreirati sliku biblioteke budućnosti preoblikovane na način da može odgovoriti zahtjevima novog vremena. Ponajviše zahvaljujući enormnom tehnološkom razvoju i izazovima koje on sobom nosi, vizije sveopšte ili univerzalne biblioteke, biblioteke bez zidova, čine se izvodive i vode ka preispitivanju postojećih i stvaranju novih teorija o budućoj ulozi biblioteke i suštini bibliotečke prakse. Interesantno je i izazovno iz današnje perspektive struke promišljati na koji način će se poimati biblioteka u bližoj ili daljoj budućnosti, kako će izgledati i koja će od postojećih vizija, naučna ili literarna, biti bliže realizaciji u stvarnosti. =
Librarianship as a science and skill of the organization of knowledge and its products is evolving and, like all other scientific or practical disciplines, it is forced to keep up with the times. In this evolutionary path, traditional theories and notions of libraries and librarianship as professions are changing and reaching far beyond the traditional ones – almost to the limits of science fictions. Nevertheless, theories which were until recently considered fictional literary and artistic performances are today already seen from an extremely constructive and rational perspective. One of the most interesting examples is the experience and vision of the library in the fictional world of Jorge Luis Borges. Following his prophetic observations woven into his literary universe, many scholars from various fields, are trying through a multidisciplinary approach to reconstruct and create an image of the library of the future reshaped in a way that can respond to demands of modern times. Mostly thanks to the enormous technological development and challenges it brings, visions of a Universal Library seem feasible and lead to rethinking of existing and creating new theories about the future role of the library and the essence of library practice. It is interesting and challenging from today’s professional perspective to think about the way that library will be understood in the near or distant future, what it will look like and which of the existing visions – scientific or literary – will be closer to realization in reality.
Formação Continuada e Permanente de Professores: Emancipação Coletiva das Práticas Pedagógicas Alienantes
Authors: Camilotti Dirce Cristiane , Gobara Shirley Takeco
Published: December 2021

O objetivo deste trabalho é oferecer uma reflexão sobre o processo de emancipação coletiva das práticas pedagógicas alienantes de um grupo de professores dos anos iniciais do Ensino Fundamental de uma escola pública. Trata-se de recorte de uma pesquisa-formação de base materialista dialética, fundamentada na Teoria da Objetivação (TO). Os resultados foram obtidos a partir das análises das interações e ações de seis professoras que apresentaram, no início da pesquisa-formação, uma prática pedagógica com foco na transmissão de informação e no individualismo, identificadas como práticas alienantes, de acordo com a TO. As análises evidenciaram a produção de novas subjetividades, materializadas nas reflexões críticas realizadas pelas professoras sobre suas práticas pedagógicas e indícios de um processo de mudança na consciência dessas professoras. Tais análises sugerem que a proposta formativa realizada, com base nos pressupostos da TO, possibilitou o desencadeamento do processo de emancipação coletiva dessas práticas pedagógicas alienantes.
Association Between Ki67 After Neoadjuvant Chemotherapy and Disease-Free Survival in Breast Cancer.
Authors: Aan Setiawan  , Umar Mulawan , Erial Bahar
Published: December 2021

Background: Post Chemotherapy Ki67 in recent year has been investigated as a predictive and prognostic factor in locally advanced breast cancer patient undergoing neoadjuvant chemotherapy.

Objectives: To describe the relationship between post-chemotherapy Ki67 and disease-free survival after neoadjuvant chemotherapy in patients with locally advanced breast cancer at Dr. Hospital. Mohammad Hoesin Palembang.

Methods: This study is an analytical observational study with prognostic test design conducted in 30 stage III B breast cancer patient. A retrospective search of a prospectively maintained clinical database was performed to identify patient treated with neoadjuvant chemotherapy at the Mohammad Hoesin Hospital. The expression of Ki67 was assessed using immunohisto-chemistry in post therapy surgical excision specimen.

Results: From 30 patients, there was a significant relationship between Post Chemotherapy Ki67 and disease- free survival in patients with locally advanced breast cancer (r = -0,742, p = 0.000). The cut off point value of Ki67 was 27,5% with an area under curve (AUC) of 0,716. The results of the post-chemotherapy Ki67 prognosis test included sensitivity 64%, specificity 60%, Positive Predictive Value 88,9%, Negative Predictive Value 25%, accuracy 63,3%.

Conclusion: There is a significant relationship between Post Chemotherapy Ki67 to disease free survival and Post Chemotherapy Ki67 can be used as a prognostic biomarker in breast carcinoma patients undergoing neoadjuvant chemotherapy.
Accuracy of a Novel Scoring System for Prediction of Response to Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer Patients
Authors: Qodir Nur , Nurindah Dwi Utami  , Erial Bahar
Published: December 2021

Background: Neoadjuvant chemotherapy (NAC) has become a widely accepted treatment option for locally advanced breast cancer (LABC). Furthermore, response to NAC is considered to be a predictor of favorable outcomes. It is known that some predictors are associated with NAC response. 

Objectives: To assess the accuracy of scoring system for prediction of response to neoadjuvant chemotherapy in LABC.

Methods: Medical record of 50 patients received NAC at Mohammad Hoesin Hospital were retrospectively analysed between July 2019 to July 2020. Response of NAC in LABC was determined with Response Evaluation Criteria in Solid Tumours (RECIST). Variables of the scoring system are risk factors of breast cancer, immunohistochemical subtype, CD4+, CD8+, CD4+/CD8+ ratio, and neutrophil to lymphocyte ratio.

Results: A total of 50 patients with LABC received and completed NAC. The mean age was 48.2 ± 11.0 at the time of diagnosis. Good response to NAC was achieved in 38 patients (76.0%). This scoring system shows a sensitivity of 77.8%, a specificity of 83.3%, a positive predictive value of 18.4%, and a negative predictive value of 24.4% with the Youden index of 66.1. The combination between less than three parity and positive estrogen receptor demonstrated better accuracy with a sensitivity of 96.3% and specificity of 77.7% and Youden index 74.

Conclusion: This pilot study suggests that this scoring system is potentially useful for predicting response to neoadjuvant chemotherapy in LABC patients and warrants further investigation in a larger population to validate this finding.
Characteristics of Peripheral Arterial Disease Patients in Vascular and Endovascular Surgery Department Dr. Mohammad Hoesin General Hospital between January 2018 - December 2019
Authors: Gayuh Prasetya  , Yusuf Fahmi Jaka , Kemas Dahlan
Published: December 2021

Background: Peripheral artery disease (PAD) is a chronic occlusive arterial disease of the extremities caused by atherosclerosis leading to stenosis or occlusion characterized by decreased blood flow to the limb, due to obstruction or narrowing of the blood vessels. PAD often underdiagnosed and poorly understood. ​​Median annual expenditure per individual for patients with PAD was $ 11.553 to $ 42.613 in the United States. The lack of data on PAD in South Sumatra was the based for investigators to conducting this study.

Methods: This research is a retrospective descriptive study. The purpose of this study was to describe the characteristics of PAD patient based on the Rutherford classification. There are 33 cases in this study.

Result: The dominant patient was male, the youngest age was 28 years old and the oldest age was 71 years, with a mean age of 55.8 years. Diabetes mellitus, stage 1 hypertension, LDL more than 100 mg/dL, ABI results that showed PAD, and stage 2 Rutherford were the dominant cases in the sample of this study.

Conclusion: Early prevention and treatment from vascular and endovascular surgery can be considered as the most important for the management of peripheral arterial disease patient.
Chest Trauma Score of Thoracic Trauma Patients in Dr. Mohammad Hoesin Palembang January-June 2020
Authors: Satria Marrantiza  , Umar Ahmat , Bermansyah  , Gama Satria  , Aswin Nugraha
Published: December 2021

Introduction: Thoracic trauma has mortality rates varying from 10% to 60%. Various scoring frameworks have been created for prognostic value in thoracic trauma patients, including the chest trauma score (CTS). This has not been studied in Indonesian patients. The authors decided to study the picture of CTS in thoracic trauma patients in the Indonesian subpopulation, especially in our hospital.

Methods: This research is an analytical observational study at dr. Mohammad Hoesin (RSMH) Palembang in January-June 2020. Our research variables are age, lung contusions, number of rib fractures, bilateral rib fractures, and Chest Trauma Score (CTS). 37 cases could be analyzed with the length of stay, ICU care, mortality, and surgery option.

Results: The most common thoracic trauma occurred at the age between less than 45 years, the highest degree of lung contusions was unilateral minor lung contusions. The most common rib fractures were <3 rib fractures. Chest Trauma Score in this study were less than 5. The CTS score had a significant relationship with length of stay and the need of ICU, but was not significantly associated with mortality and surgery option.

Conclusion: Chest trauma score can be used to consider the length of treatment and priority needs of the ICU which will be prepared for the management of thoracic trauma patients, especially the young who are accompanied by lung contusions and rib fractures.
Effectiveness of Preoperative Incentive Spirometry in Patients Following Elective Thoracotomy for Prevention of Postoperative Pulmonary Complication
Authors: Sylvia Noviani Saing  , Satria Gama , Bermansyah  , Irfannuddin
Published: December 2021

Background: Thoracotomy can cause postoperative impairment of respiratory function and highly risk turns as Postoperative Pulmonary Complication (PPC). One of strategies to decrease risk of PPC in preoperative evaluation is lung expansion maneuvers include Incentive Spirometry (IS). Incentive Spirometry was breathing technique that sustained maximal inspiration, using device which give visual feedback. This study aims to know effectiveness of using preoperative IS in reducing incidence of PPC in thoracotomy patients.

Methods: Experimental study with post test only design. Comparing emerged PPC with Melbourne Group Scale Version 2 (MDG-2) criteria in elective posterolateral thoracotomy patients who given IS and non IS preoperative. Data were analyzed using chi square test.

Results: Total samples was 32 patients. There was 11 patients had PPC, which 6 recieved IS preoperatively. There was no relation between PPC with age, sex, height, smoking history proportion (p value>0,05). Chi square test showed there was no relation between using IS preoperative and PPC incidence(p>0,710).

Conclusions: IS preoperative was not effective in preventing PPC in elective thoracotomy patients.
In-Pixel CTIA & Readout Circuitry for an Active CMOS Image Sensor
Authors: Menssouri Aicha , El Khadiri Karim , Tahiri Ahmed
Published: December 2021

This work aims to design and simulate an in-pixel Capacitive Transimpedance Amplifier (CTIA) and peripheral circuitry that ensures pixel reading. Each pixel circuit is composed of four transistors using 90nm CMOS technology with a supply voltage of 1.8 V and is part of an array of pixels that make up a CMOS image sensor with peripheral circuitry. Pixel output is sent to a delta difference sampling (DDS) circuit to filter reset voltages. The Gain Margin achieved for the in-pixel CTIA is 44dB and 91dB for the Phase Margin. We also present measured pixel parameters and give a comparison with prior work. The timing and readout circuitry is also described.
Measurement Validation of Factors Influence SME Business Performance in Malaysia
Authors: Ab Wahab Nur Yuhainis , Musa Rusnifaezah , Yusoff Siti Haryani Mat
Published: December 2021

Organizations are increasingly under pressure to shift their production methods from traditional to sustainable, reinforcing the requirement to monitor their sustainability performance. The slow performance growth of Malaysian manufacturing companies remains a concern. The goal of this research is to highlighted the measurement used in the Malaysian SME context. Data were collected using survey method. A survey method was employed to collect a total of 1,071 responses in SME firms using proportional stratified sample technique. Using statistical packages for the social sciences (SPSS) version 27, this research focused on data validity and reliability. Findings of factor analysis confirmed 3 factors for the ICT adoption variable, were formed while 1 factor for the innovation variable, 4 factors for the competitiveness variable and 1 factor for the business performance. Only 2 items were dropped due to the weak loadings. Meanwhile the reliability analysis also indicates all the constructs and dimensions achieve good reliability value at more than 0.8. This research demonstrates the measurement validity and reliability of the research variables were inconsistent due to culture setting. This research highlighted the measurement used in the Malaysian SME context. The findings of this research withdraw a conclusion that the validity and reliability of item and construct of this research is proficient and consistent with the previous studies.
Formar en bioética, desde lo intercultural, a través del arte
Authors: Barraca Mairal Javier
Published: December 2021

El tema de nuestra investigación consiste en la formación bioética a partir de lo intercultural por medio del Arte. Se parte de una noción honda de lo cultural y de la especial fecundidad para las personas y grupos humanos de los encuentros interculturales. Se analizan experiencias concretas formativas en el contexto universitario, relativas al valor de la vida humana, la lucha frente al racismo, el respeto al otro, etc. Se proyecta esto en el marco de los medios digitales y tecnológicos cruciales hoy en educación. Se extraen diferentes conclusiones que revisten interés para la aplicación práctica de estos aprendizajes.
The Struggle for National Sovereignty and International Status of the Ukrainian Cossack State (Second Half of the XVII–XVIII centuries)
Authors: STENHACH Nadiia
Published: December 2021

The question of the qualification of the status of Ukraine-Hetmanate remains relevant, because it was not regulated legally and was considered by contemporaries only in the political sphere, which led to different points of view on this issue in historical and legal science. To establish the legal status of Ukraine at the end of the XVII — beginning of the XVIII century possibly on the basis of Ukrainian-Russian and Russian-Polish agreements, actually existing Ukrainian-Russian relations and, in particular, studying the institution of the hetman — the head of state and the main bearer of state sovereignty. This is the purpose of this study. Scholars consider Ukrainian-Russian agreements or contract articles of the second half of the XVII century as a kind of constitutional acts, sources of state law of Ukraine, which on the basis of Cossack legal customs regulated relations between Ukraine and Russia, as well as legally enshrined the «rights and freedoms» of the Cossacks, military-administrative system, partially determined the activities of public authorities and administration. But, as it is well known, the Ukrainian-Russian agreements did not directly indicate the status of the Ukrainian state, but legally affirmed the basic state and legal institutions of Ukraine and, consequently, its sovereignty, which actually existed on the basis of Cossack customary law. These agreements were in the nature of a bilateral international legal act, where the Zaporozhian Army and the Moscow Kingdom acted as parties to the treaty process, which was accompanied by the coordination of positions inherent in international legal relations, taking into account the needs and interests of the parties, establishing their rights and responsibilities. But the parties were not equal contractors of the treaty, because the Zaporozhian Army provided a draft agreement, and the tsarist government amended it and ratified it in the form of «awards». The Russian authorities saw Ukraine as an integral part of their own state and tried to incorporate its territory. The hetman and most of the Cossack officers believed that the Zaporozhian Army retained state sovereignty and was under the protectorate of Russia. Only the events of 1708–1709 forced the Ukrainian political elite (except for I. Mazepa’s followers) to recognize the autonomous legal position of the Zaporozhian Army within Russia. The article highlights the main directions in the activities of the Hetman’s administration to establish the sovereignty of the Ukrainian government in domestic and foreign policy during the second half of the XVII–XVIII centuries.
The Development of Consumer Protection Policy from Roman Law to Modern European Union Law
Authors: KIRYK Alla
Published: December 2021

The article examines the development of consumer protection policy from the most ancient historical acts to modern legal acts of the European Union. The key laws of the Roman Empire in the field of consumer protection have been studied, among which the main ones are: «Lex Iulia de Annona», «Edictum de pretiis rerum venalium — Edict of maximum prices», «Civil Code» of Emperor Justinian. It is determined that the studied legislative acts were the first attempts to consolidate the protection of the rights of buyers (consumers). Roman law, which became the basis of modern legal systems in Europe and many non-European countries, has not lost its relevance. Ancient Roman laws are compared with the modern practice of the European Union. The history of the emergence of consumer law in the European Community is considered, which is divided into three key stages from the establishment of the European Community to modern EU policy. It is determined that at the beginning of its creation the EU policy of consumer protection was considered as an element of ensuring the sustainable operation of the internal market. The key constituent acts of the Union are considered, among which the Treaty of Rome of 1957, the Single European Act of 1987, the Treaty of Amsterdam of 1997 and the Charter of Fundamental Rights of the European Union of 2000 are highlighted. The analysis of Art. 2 of the Treaty of Rome stipulates that one of the key goals — protection and improvement of living standards was interpreted also as consumer protection. This strategy was later strengthened by the Amsterdam Treaty of 1997, which identified the promotion of a high level of consumer protection as one of the Community’s tasks. The current EU policy in the field of consumer protection, which is aimed at updating legislation in accordance with modern realities, is studied. Among the key acts of secondary law is the EU Directive № 2019/2161, which focuses on better application and modernization of legislation on consumer protection and amends existing EU directives. It is determined that the current consumer protection policy in the EU ensures the proper and effective functioning of the single market through constant updating of legislation taking into account social, technological, economic and environmental changes.
Legal Provision of Components of the Structural-Functional Model of Public Administration in the Field of Healthcare
Authors: DEMIKHOV Oleksii
Published: December 2021

Relevance of research. Medical care providing for bronchopulmonary dysplasia is an urgent problem of modern medicine. Currently, there is a need to develop a model of medical care for children with bronchopulmonary dysplasia with a high risk of dysplastic pathology of the bronchopulmonary system. The relevance of such a model is due to the existing socio-medical significance of the problem of health. The purpose of the study: to develop a set of regulatory and legal support for the structural and functional model of medical care for children with bronchopulmonary dysplasia. Materials and methods of research. The analysis of scientific sources and practical management questions is carried out, the directions of the further research are chosen. The following methods are used: system approach, bibliosemantic, epidemiological and statistical. Results and discussion. The article examines various scientific sources and discusses the results of management decisions in medical institutions. The draft laws discussed in the publication offer tools for formulating and implementing public health policy. This model of the system of medical care for children with bronchopulmonary dysplasia has such distinctive features as systemic and personalized approach with the integration of efforts of specialists of related profiles, as well as cost-effectiveness, as the resource base is effectively used in the medical system. Conclusions. The author clarifies the powers of the subjects of public health policy, details the requirements for monitoring the implementation of public health policy, the procedure for conducting and evaluating effectiveness. In order to improve the legal framework, the article presents the directions of implementation of draft laws prepared during 2013–2016. The terminological apparatus, which is harmonized with international standards, has been supplemented. Prospects for further research. Further research should focus on the socio-medical effectiveness of the legislative and regulatory support of the components of the structural-functional model, which are related to assessing their impact on the implementation of health technologies at the regional, local community and family levels.
Quantitative Risk Assesment of Benzene Exposure in Printing Industry X Surabaya City
Authors: Amanda Fithri Habibati  , Abdul Rohim Tualeka  , Juliana Jalaludin  , Syamsiar Russeng  , Ahsan  , Puji Rahmawati
Published: December 2021

Benzene is a compound chemically volatile and lasts a long time in the air and quicklyinhaled into the human body. The use of benzene is widely used in various industries, one ofwhich is the printing industry. Benzene produced right in the printing industry are ink, cleaning fluid,and when the machine in operation. Workers exposed to benzene can risk cancer and non-cancer healtheffects that are harmful to the human body. This study aimed to assess cancer and non-cancer risk ofworkers in the printing industry X Surabaya City. This research is observational, cross-sectional withthe same sample with a total population of 11 workers in the printing industry X Surabaya City. Therisk assessment method uses four stages: hazard identification, exposure analysis, dose and responseanalysis, and risk characterization. This research shows that the average concentration of benzene is1.0729 mg/m3 or 0.34 ppm. RQ value > 1 both real-time and lifetime. As many as 63.6% of workershave real-time ECR >10 -4, and 81.8% of workers have ECR lifetime >10-4. This study concludes thatworkers are in an unsafe condition and have non-carcinogenic and carcinogenic health risks.
Selective sulfonylation and isonitrilation of para-quinone methides employing TosMIC as a source of sulfonyl group or isonitrile group
Authors: Qu Chuanhua , Huang Run , Li Yong , Liu Tong , Chen Yuan , Song Guiting
Published: December 2021

Chemoselective sulfonylation and isonitrilation reactions for the divergent synthesis of valuable diarylmethyl sulfones and isonitrile diarylmethanes starting from easy-to-synthesize para-quinone methides (p-QMs) and commercially abundant p-toluenesulfonylmethyl isocyanide (TosMIC) by using respectively zinc iodide and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as catalysts were developed. The distinguishing feature of this method is that TosMIC plays a dual role from the same substrates in the reaction: as a sulfonyl source or as an isonitrile source. The synthetic utility of this protocol was also demonstrated in the synthesis of difluoroalkylated diarylmethane 5 and diarylmethane ketone derivatives 6 and 7, which are important core structures in natural products and medicines.
Analisis Karakteristik Butir Soal Fisika Dengan Pendekatan IRT Penskoran Dikotomus dan Politomus
Authors: Saepuzaman Duden , Istiyono Edi , Haryanto Haryanto , Retnawati Heri , Yustiandi Yustiandi
Published: December 2021

Penelitian ini bertujuan mendeskripsikan parameter butir soal Fisika materi Usaha dan Energi menggunakan pendekatan item response theory (IRT) penskoran dikotomus dan politomus. Penelitian ini merupakan penelitian deskriptif kuantitatif. Subyek penelitian sebanyak 1175 siswa SMA kelas XI yang tersebar di provinsi Jawa Barat dan Banten  yang terdiri 450 siswa laki-laki dan 725 siswa perempuan. Data respon dengan penskoran dikotomus dianalisis menggunakan pendekatan teori respon butir dengan program BILOG-MG sedangkan untuk penskoran politomus dianalisis dengan pendekatan GPCM  menggunakan program R guna mendapatkan informasi tentang tingkat kesukaran, daya beda, kecocokan butir, estimasi kemampuan peserta didik. Hasil uji kecocokan model menunjukkan bahwa butir soal paling banyak fit dengan model 2PL. Hasil penelitian menunjukan bahwa parameter butir soal Fisika materi Usaha dan Energi dengan penskoran dikotomus menunjukkan keseluruhan butir memiliki kriteria butir baik dan dengan penskoran politomus menunjukkan hampir seluruh butir kategori baik