bluuebunny/crossref_metadata_2025 huggingface dataset:
Smart Strawberry Advisory System for Mobile Devices
Authors: Fraisse Clyde W. , Peres Natalia A. , Debastiani Andreis José Henrique
Published: November 2022

Like the web-based SAS, the SAS: Strawberry Advisory System mobile app monitors real-time and forecast weather conditions that increase the risk for Botrytis (gray mold) and anthracnose fruit rots, providing risk level information for each disease. The app provides easy access to the information growers need to make spraying decisions in the field, saving them time, helping improve disease control, and avoiding unnecessary fungicide applications. This 3-page fact sheet provides an overview of the SAS mobile app. Written by Clyde W. Fraisse, Natalia Peres, and José Henrique Andreis, and published by the UF Department of Agricultural and Biological Engineering, August 2015.  
AE516/AE516: Smart Strawberry Advisory System for Mobile Devices (ufl.edu)
Carp Edema Virus Disease (CEVD) / Koi Sleepy Disease (KSD)
Authors: Hesami Shohreh , Viadanna Pedro , Steckler Natalie K. , Spears Staci , Thompson Patrick M. , Kelley Karen L. , Yanong Roy P. E. , Francis-Floyd Ruth , Shelley Johnny , Groff Joseph M. , Goodwin Andy , Haenen Olga L. M. , Waltzek Thomas B.
Published: November 2022

Carp edema virus disease is killing wild and cultured varieties of carp and worrying koi enthusiasts and carp aquaculturists in the United States and around the world. The disease causes skin lesions and swelling and is sometimes called “koi sleepy disease” because infected fish become lethargic and unresponsive. This 6-page fact sheet describes symptoms, diagnosis, prevention, and what fish producers, wholesalers, or retailers can do if they suspect carp may have contracted the disease. Written by Shohreh Hesami, Pedro Viadanna, Natalie Steckler, Staci Spears, Patrick Thompson, Karen Kelley, Roy Yanong, Ruth Francis-Floyd, Johnny Shelley, Joseph Groff, Andy Goodwin, Olga Haenen, and Thomas Waltzek, and published by the School of Forest Resources and Conservation Program in Fisheries and Aquatic Sciences, October 2015.

FA189/FA189: Carp Edema Virus Disease (CEVD) / Koi Sleepy Disease (KSD) (ufl.edu)
The Effects of Regulation on Ornamental Aquaculture Farms in Florida
Authors: Boldt Noah C. , Van Senten Jonathan , Engle Carole R. , Cassiano Eric J. , DiMaggio Matthew A.
Published: November 2022

Florida’s diverse ornamental aquaculture industry has many unique challenges that set it apart from other aquaculture commodity groups.  The numerous production techniques, diversity of species, and various market outlets make the ornamental aquaculture industry an intriguing study in how regulations impact the industry.  By understanding those regulatory impacts, we can streamline efforts to address them.  A study was conducted to measure the regulatory impact on ornamental aquaculture farms in Florida using on-farm data from 2018. All farms were censused in the state and results covered 82% of the industry with a response rate of 41% of farms. This factsheet discusses the results of that study and the regulatory burden that the ornamental aquaculture industry in Florida endures.
Market Trends for US Berry Crops: Implications for Florida Blueberry, Blackberry, and Raspberry Producers
Authors: Morgan Kimberly L.
Published: November 2022

This publication presents production and market data specific to US blueberry, blackberry, and raspberry, with the intent to characterize related supply and demand trends recorded from 2000 to 2021. Implications from this market analysis are useful to inform production, harvest, and marketing decisions of Florida growers interested in, or involved with, the commercial berry industry. Written by Kimberly L. Morgan, and published by the UF/IFAS Food and Resource Economics Department, November 2022.
Social Organization of Honey Bees
Authors: Mortensen Ashley N. , Smith Bryan , Ellis James D.
Published: November 2022

A honey bee colony is a superorganism, which means that together its members function like a single animal. Bees within a colony work together like the cells in a human body. They warm the colony in the winter by vibrating their wings to generate heat and cool it in the summer by ferrying in droplets of water and fanning air over them. Worker bees fan air into and out of the colony entrance in distinct inhalations and exhalations. Colonies reproduce by swarming to create new daughter colonies that in turn thermoregulate, breathe, and reproduce just as a single autonomous animal does. In three pages this fact sheet explains the intricate caste system and age-based division of labor that allows colonies of humankind’s best-loved pollinators to function and thrive. Written by Ashley N. Mortensen, Bryan Smith, and James D. Ellis, and published by the Entomology and Nematology Department, November 2015.

ENY-166/IN1102: The Social Organization of Honey Bees (ufl.edu)
First Aid for Pesticide Exposure
Authors: Fishel Frederick M.
Published: November 2022

Pesticide poisoning is a commonly under-diagnosed illness. This 5-page fact sheet describes how to recognize the early symptoms of pesticide exposure and provide basic first aid for the treatment of victims. It explains how to provide initial treatment in the case of pesticide exposure on the skin, in the eye, through inhalation, and in the mouth or swallowed. Written by Frederick M. Fishel, and published by the Agronomy Department, December 2015.
PI256/PI256: First Aid for Pesticide Exposure (ufl.edu)
The Mediating Role of Parental Non-involvement to Goals of Progress With Academic Dishonesty in Students
Authors:   Department of Psychology, Semnan Branch, Islamic Azad University, Semnan, Iran., Taheri Farahnaz , Jahan Faezeh ,   Department of Psychology, Semnan Branch, Islamic Azad University, Semnan, Iran., Yaghoobi Abolghasem ,   Department of Psychology, Faculty of Economics and Social Sciences, Bu-Ali Sina University, Hamedan, Iran., Jahan Ali ,   Department of Psychology, Semnan Branch, Islamic Azad University, Semnan, Iran.
Published: November 2022

Objective: This study aims to investigate the mediating role of parental non-involvement in relation to goals of progress with academic dishonesty in students. Methods: This is a correlational study in which the relationships between the variables of the proposed model were investigated using the structural equation modeling method. The statistical population included all female high school students in Semnan City, in the academic year 2020. Using the convenience sampling method, 350 people were selected as the sample. The academic dishonesty questionnaire, goals of progress questionnaire, and family non-involvement questionnaire were used as measurement tools. Correlation coefficients (using the SPSS software) and structural equation modeling analysis (using AMOS statistical software) were employed to investigate the variables of the academic dishonesty prediction model. Results: The findings indicated that the data fit the model, and the results showed that goals of progress had a direct effect on academic dishonesty and family non-involvement. In addition, family non-involvement had a direct effect on academic dishonesty. Finally, goals of progress through the mediating variable had an indirect effect on academic dishonesty. Conclusion: To increase students’ academic honesty, a set of internal, external, individual, and family factors of students should be considered.
Investigating the Relationship Between Differentiation and Moral Justice in Sexual Satisfaction
Authors:   Department of Psychology, Semnan University, Islamic Azad University, Semnan, Iran., Khabiri Pooya Avisa , Mohammadi Mohsen ,   Department of Psychology, North Tehran Branch, Islamic Azad University, Tehran, Iran., Karami Abolfazl ,   Department of Counseling, Allameh Tabatabai University, Tehran, Iran., Rahimian Booger Isaac ,   Department of Clinical Psychology, Faculty of Psychology and Educational Sciences, Semnan University, Mahdishahr, Iran.
Published: November 2022

Objective: This study aims to investigate the model of the relationship between differentiation and moral justice in sexual satisfaction. Methods: This descriptive and applied research was done based on structural equations. The statistical population consisted of 300 individuals who were selected via the convenience sampling method. The differentiation questionnaire moral justice questionnaire were distributed to the individuals online. Results: The results indicated that differentiation (0.243) (P<0.01), and moral justice (0.175) (P<0.01) are related to sexual satisfaction. Conclusion: The individual and interpersonal dimensions of human beings can affect sexual satisfaction. According to different human dimensions, it is suggested that cognitive issues, interpersonal relationships, and moral dimensions be trained even before starting marital life as a model. Meanwhile, conditions can be provided to promote sexual satisfaction and its continuation in a safe and healthy environment to help maintain this path.
Mutual Synchronization of Antiferromagnetic Spintronic Oscillators
Authors: Mitrofanova A. Yu. , Safin A. R. , Kravchenko O. V. , Nikitov S. A.
Published: November 2022

Introduction. Recent studies into the properties of spintronic oscillators have led to broadening their scope of practical application as devices for generating and processing signals. The practical implementation of spintronic oscillators is, however, significantly limited by their low power capacity, thus requiring synchronization between devices.

Aim. Determination of conditions for the implementation of the synchronous regime of two antiferromagnetic spintronic oscillators coupled by a common current.

Materials and methods. To simplify the numerical simulation of a system of coupled resistively antiferromagnetic oscillators, the method of multiple-time-scale analysis was used. This allowed a system of Kuramoto equations to be considered instead of the original system. To determine the locking band of the Kuramoto model, the homoclinic trajectory approximation method was applied.

Results. A system of Kuramoto equation for the phases of partial oscillators under the influence of the inertial term and phase shift was obtained. Expressions describing the locking and synchronization band as functions of the system parameters (bias currents and sizes) were derived. The numerically simulated Kuramoto model was used to determine the bands of the synchronous and asynchronous regimes.

Conclusion. The results of numerical simulations of the system of Kuramoto equations and the Adler equation for two coupled spintronic oscillators agree well with the theoretically calculated values of locking and synchronization ranges. The scheme for reducing the model of antiferromagnetic oscillators to a Kuramoto model can be further extended to the case of a larger number of coupled oscillators, which will simplify computational experiments and significantly reduce the time required for numerical simulations.
Desain Modul Braille Berbasis Cerita Dengan Pendekatan Humanistik Untuk Meningkatkan Nilai-Nilai Kemandirian Siswa SLB Donbosco Wonosobo
Authors: El Qorny Ashief
Published: November 2022

This study aims to produce modules and describe validation and describe the effectiveness of story-based braille module designs with a humanistic approach to improve the values of independence of ABK students. This study used the R&D method. The subject of the study was a middle-level or grade IX Donbosco SLB student. The steps used in this study are data collection, product design/model I, expert validation/model II, product revision, and product implementation. Based on the results of expert validation obtained by 87%, learning media have expert reviews of 92%. It has shown a very valid category, and the story-based braille module has been declared viable and usable. We filled out a questionnaire and gave it to our students, achieving a percentage of 90% It shows that the design of story-based braille modules with a humanistic approach to improving the values of independence of ABK students is effectively used in learning with an "excellent" level of effectiveness.
The Effect of Rib Fabric Pattern and Yarn Composition on the Mechanical Properties of Polyester Matrix Composites Reinforced by Weft-Knitted Fabric
Authors: İNCE Mehmet Erdem , İÇOĞLU Halil İbrahim
Published: November 2022

In this study, polyester matrix composites reinforced by 1x1, 2x2, half- and full-cardigan rib pattern weft-knitted fabrics from glass and glass/aramid hybrid yarns were produced. Tensile, flexural and impact tests were applied to the composites. The 2x2 rib pattern composite showed the highest thickness and density. The hybridization of glass yarn with aramid yarn increased the thickness, while it decreased the density of composites. The 2x2 rib pattern composite showed the highest tensile modulus and tensile strength. Yarn hybridization increased tensile strength at statistically significant level. The composite with full-cardigan rib pattern displayed considerably higher flexural modulus and flexural strength than the composites with the other patterns. When glass and hybrid composites were considered separately, the rib fabric pattern exhibited significant effect on maximum load. The rib fabric pattern displayed also significant effect on absorbed energy for glass composites. The yarn hybridization dramatically increased maximum load and absorbed impact energy.
Buruli-RifDACC: Evaluation of the efficacy and cost-effectiveness of high-dose versus standard-dose rifampicin on outcomes in Mycobacterium ulcerans disease, a protocol for a randomised controlled trial in Ghana
Authors: Amoako Yaw Ampem , Agbanyo Abigail , Novignon Jacob , Owusu Lucy , Tuffour Joseph , Asante-Poku Adwoa , Hailemichael Yohannes , Mosweu Iris , Canter Ruth , Opondo Charles , Allen Elizabeth , Pitt Catherine , Yeboah-Manu Dorothy , Walker Stephen L. , Marks Michael , Phillips Richard Odame ,   SHARP collaboration
Published: November 2022

Background: Buruli ulcer (BU) can lead to disfiguring ulcers and permanent disability. The 2030 World Health Organization (WHO) road map for Neglected Tropical Diseases (NTDs) calls for major scaling up in diagnosis and management to eliminate disability due to the disease. Current treatment for BU is with daily oral rifampicin (10mg/kg dose) and clarithromycin (15mg/kg dose) for eight weeks, combined with standard gauze wound dressings. Dialkylcarbamoyl chloride (DACC)-coated dressings have been shown to irreversibly bind bacteria on wound surfaces resulting in their removal when dressings are changed.  This trial aims to determine whether combining a high-dose oral rifampicin regimen with DACC dressings can improve the rate of wound healing relative to standard-dose oral rifampicin combined with DACC dressings.

Methods: This is an individual, multi-centre Phase 3 randomised controlled trial, which will be conducted in three clinical sites in Ghana. The primary outcome measure will be the mean time to clearance of viable mycobacteria. Cost and health-related quality of life data will be collected, and a cost-effectiveness analysis will be performed.

Discussion: The findings from this trial could lead to a change in how BU is treated. A shorter but more efficacious regimen would lead to improved treatment outcomes and potentially substantial financial and economic savings.

Trial registration

Pan African Clinical Trials Repository (registration number; PACTR202011867644311). Registered on 30th November 2020.
Sistema integrado modular para seguridad y confort de Viviendas Inteligentes basado en Internet de las Cosas
Authors: Agama Chico Alfonso Jacinto , Baldeón Navarrete Emerson Gabriel , Saa Ayala Juan Fernando , Arias Morán José Manuel
Published: November 2022

En la actualidad, los peligros existentes en el territorio ecuatoriano obligan a las personas a mantener sus hogares monitoreados y controlados, pero esto es sumamente complicado, ya que adquirir un Sistema y su equipamiento para realizar esta actividad es sumamente costoso y en algunos casos requiere de otros factores para poder funcionar correctamente, lo cual es una desventaja para la mayor parte de la ciudadanía y mucho más con la crisis económica que afecta a todos los países del mundo, por ello, el objetivo de la presente investigación, fue desarrollar un sistema con hardware modular, que permita el monitoreo y control de una vivienda, mediante el uso de sensores de bajo costo, permitiendo el acceso al sistema desde cualquier parte del mundo, logrando que la información que envía y recibe el usuario sea en tiempo real.
Evaluasi Kepuasan Pengguna Sistem Informasi Akademik Menggunakan Webqual 4.0 Dan Importance-Performance Analysis
Authors: Santoso Herdiesel , Widodo Wahyu
Published: November 2022

Penerapan sistem informasi akademik tidak selalu berjalan dengan baik. Evaluasi terhadapat kepuasan pengguna sistem mutlak dilakukan. Tujuan penelitian ini adalah untuk mengetahui kepuasan pengguna website Sistem Informasi Akademik (SIAKAD) STMIK El Rahma, dilihat dari kualitas layanan yang dirasakan dengan tingkat harapan. Metode yang digunakan adalah kombinasi antara WebQual 4.0 dan Importance Performance Analysis (IPA). Langkah penelitian dimulai dari studi literatur tentang metode yang digunakan, kemudian dilanjutkan dengan pengumpulan data menggunakan kuesioner yang berasal dari instrumen WebQual. Untuk melihat kuesioner tersebut sudah layak atau belum digunakan untuk mengambil data, dilakukan pengujian validitas dan reliabiltas terhadap pertanyaan dalam kuesioner. Analisis data dilakukan untuk melihat kesenjangan atau gap, dan penyusunan mariks IPA. Hasil penelitian menunjukan bahwa indikator - indikator WebQual untuk kepuasan pengguna layanan SIAKAD, terdistibusi pada kuadran II dan kuadran III matriks IPA. Sedangkan berdasarkan analisis kesenjangan (GAP) kepuasan pengguna untuk dimensi usabilitas, kualitas informasi serta interaksi dan kualitas layanan menunjukan belum dapat memenuhi harapan dari pengguna.
 
Kata kunci: importance-performance analysis,  user satisfaction , WebQual 4.0
Development of the Composition and Technology for Production a Solid Dispersion System by Hot Melt Extrusion to Increase the Bioavailability of the Active Substance
Authors: Gusev K. A. , Maimistov D. N. , Pavlovsky V. I. , Aliev A. R. , Pavlovsky A. V. , Ivanova O. V. , Tsyrenov D. O. , Flisyuk E. V.
Published: November 2022

Introduction. The solubility of an active pharmaceutical ingredient plays a major role in drug absorption. Hot melt extrusion is a batch or continuous process that allows creating solid dispersion systems based on various carriers in order to increase solubility and bioavailability of active substances. Development of effective and safe analgesics is one of the most vital tasks of organic and medicinal chemistry. An innovative non-opioid analgesic with very low toxicity and low dosage, but practically insoluble in water, was used in this work. It was suggested to obtain a solid dispersion by hot melt extrusion in order to increase bioavailability.

Aim. Development a hot melt extrusion technology for production of a solid dispersion system of PAV-0056 as an active substance and Plasdone™ S-630 as a polymeric carrier to increase the solubility.

Materials and methods. PAV-0056 (methyl-2-(7-nitro-2-oxo-5-phenyl-3-propoxy-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)acetate) (JSC "Organica", Russia) Figure 1; Plasdone™ S-630 (Boai NKY Pharmaceuticals Ltd., China); PEG-1500 (Clariant, Switzerland); acetonitrile for chromatography (Thermo Fisher Scientific, Germany). Extrudates were obtained using a HAAKE™ MiniCTW co-rotating twin-screw laboratory extruder (Thermo Fisher Scientific, Germany). Extrudates were examined by optical microscopy and differential scanning calorimetry, and time of water solution stability was determined. The quantitative content of the active substance and related impurities in the 2.5 % solid dispersion of PAV-0056 was determined by HPLC-UV.

Results and discussion. Hot melt extrusion process conditions were established for a mixture of 2.5 % PAV-0056 and Plasdone™ S-630. Stability of the extrudate solution in water was studied, the content of the active substance and impurities in the extrudates was determined. Based on the binary mixture, a composition containing 10 % of PEG-1500 was developed. The optimal conditions for the extrusion process were chosen for obtaining a solid dispersion system that meets the requirements of the regulatory documentation for the content of the active substance and impurities.

Conclusion. The binary mixture proved to be unsuccessful for the creation of SDS by hot melt extrusion due to significant accumulation of impurities during the extrusion process. By adding PEG-1500 to the composition, it was possible to considerably lower the operating temperature of the process, reduce the impurity content in the extrudate, and maintain satisfactory stability of the PAV-0056 solution in water.
Development of a Preparative Method for Obtaining an Enantiomerically Pure Substance of Salbutamol by Supercritical Fluid Chromatography
Authors: Tsarev V. N. , Bazarnova N. G. , Mikushina I. V.
Published: November 2022

Introduction. An increasing number of studies conducted in various countries in the field of biopharmacy convincingly show the differences in the physiological effects on the human body of stereoisomers of pharmaceutical substances. As a rule, one of the enantiomers has the necessary pharmacological effect, the other enantiomer is either inert or has a negative side effect. Currently, it is important to obtain enantiomerically pure pharmacological substances from their racemic mixtures.

Aim. Obtaining the R-isomer of salbutamol from a racemic mixture of salbutamol and developing a preparative procedure for chiral separation by supercritical fluid chromatography (SFC) with a yield of the target product sufficient for the production process.

Materials and Methods. Supercritical fluid chromatography (SFC) is widely used for analytical and preparative separations of enantiomers of pharmaceutical substances. The relevance of the use of supercritical fluid chromatography SFC is largely due to the fact that it uses sub- or supercritical carbon dioxide (SC-CO2) as the main component of the mobile phase (MP). Studies were carried out on semi-preparative Investigator SFC (Waters Corporation, USA) and preparative Prep 200 qSFC (Waters Corporation, USA) supercritical fluid chromatographs with PDA detectors. Samples were weighed to the nearest 0.0001 g on a XPE206DR balance (Mettler Toledo, USA).

Results and discussion. The process of chiral separation of salbutamol sulfate by the SFC method on Prep 200 qSFC (Waters Corporation, USA) was studied. It was revealed that in the chromatographic system under supercritical conditions, the salt is separated into acidic and basic residues, which significantly reduces productivity and shortens the duration of continuous operation of the chromatograph. Conditions for the preparative chiral separation of the racemic mixture of salbutamol base into R- and S-isomers with high enantioselectivity and productivity have been developed. The resulting R-isomer of salbutamol base can be converted into the pharmaceutical substance in the form of sulfate or other salt without loss of enantiomeric purity, the S-isomer can be subjected to racemization and subsequent use.

Conclusion. A preparative method has been developed for the chiral separation of a racemic mixture of salbutamol by supercritical fluid chromatography (SFC) with a yield of the target product (R-isomer) of 5.5 g per shift (8 hours).
Meningkatkan Perkembangan Bahasa Anak Usia Dini Dengan Metode Bernyanyi di RA Al-Ikhlash
Authors:   Universitas Pendidikan Indonesia, Sri Wahyuni Ajeng
Published: November 2022

Masa kanak-kanak merupakan tahap awal dari proses berkembang seseorang yang berada di fase utama atau dikenal dengan masa golden age, segala bentuk kemampuan yang terdapat pada diri anak dapat dikembangkan pada masa ini. Pendidikan anak usia dini harus dipersiapkan secara sistematis agar anak dapat menerima rangsangan secara insentif untuk mengembangkan berbagai potensi yang dimiliki dan pendidikan anak usia dini adalah upaya pendidik maupun orang tua untuk merawat dan mengasuh anak. Metode bernyanyi merupakan salah satu kegiatan efektif yang dapat dijadikan sebagai upaya pengembangkan aspek bahasa anak usia dini. Setiap lagu yang dinyanyikan mengandung banyak makna juga manfaat, seperti dalam aspek bahasa, pembiasaan, kognitif, seni, ataupun kegiatan fisik motorik. Penelitian ini berfokus bukan hanya pada stimulus perkembangan bahasa anak saja, akan tetapi melihat bagaimana respon dari diri anak terhadap kegiatan bernyanyi yang bertujuan untuk meningkatkan perkembangan bahasa anak tersebut.
Meningkatkan Kemampuan Motorik Halus Anak Usia Dini Melalui Kreativitas Bermain Plastisin Di Tk Darul Falah
Authors:   Universitas Pendidikan Indonesia, Sahla Sabilla Listia
Published: November 2022

Tujuan dari dibuatnya artikel ini selain untuk menambah pengetahuan tentang perkembangan motorik anak usia dini juga mengetahui kemampuan motorik halus anak usia dini dengan cara bermain kreativitas plastisin di Tk Darul Falah dan sebagai penambah pengalaman untuk dijadikan gambaran kegiatan dimasa yang akan datang. Dalam penelitian ini ditemukan masalah anak yang kurang dalam kreativitasnya sehingga dalam kegiatan bermain plastisin mencontek karya temannya. Teknik yang digunakan yaitu dengan metode Penelitian Tindakan Kelas (PTK). Penelitian dilakukan 2 kali selama 2 hari. Hari pertama saat kegiatan anak mencontek karya yang dibuat temannya karena kreativitasnya belum terlatih dan tidak mendapatkan ide sementara pada penelitian kedua anak sudah mampu membuat karyanya sendiri tanpa mencontek dari temannya. Pada penelitian kedua tersebut guru andil memberikan ide kreatif kepada anak dengan membacakan dongeng sebelum membuat karya. Oleh karena itu, dapat disimpulkan bahwa guru harus memiliki kreativitas yang tinggi supaya anak juga bisa mengembangkan idenya dari guru tersebut.
Peran Guru Dalam Pembentukan Karakter Religius Pada Anak Usia Dini 5-6 Tahun Di TK Manurung Goto Tidore Kepulauan
Authors:   Universitas Khairun, Achmad Fatoni , Al Hadad Bujuna , Rasyid Masayu
Published: November 2022

Tujuan penelitian untuk mengetahui peran guru dalam pembentukan karakter religius pada anak usia dini 5-6 tahun di TK Manurung Goto Tidore Kepulaun. Penelitian ini menggunakan pendekatan kualitatif dengan metode deskriptif. Pengumpulan data dengan metode observasi, wawancara dan dokumentasi. Hasil penelitian menunjukan bahwa pembentukan karakter religius pada anak usia dini di laksanakan oleh guru, di antaranya: 1. Nilai ibadah, pembentukan nilai karakter religius pada aspek ini adalah dengan cara pembiasaan di mulai dari hal-hal yang sederhana seperti sholat, berdoa, adzhan, bersholawat kepada nabi dan berzikir. 2. Nilai kedisiplinan, pembentukan karakter religius pada aspek nilai kedisiplinan terkait dengan kepatuhan, ketaatan dan ketertiban sudah di terapkan di TK Manurung Goto Tidore Kepulaun tetapi hanya beberapa anak yang bisa melakukannya secara sempurna sedangkan anak yang lainnya belum. 3. Nilai keteladanan, pembentukan karakter religius pada aspek nilai keteladanan di terapkan dengan bersikap sopan santun di hadapan anak-anak serta guru menjadi contoh yang baik untuk anak-anak dengan cara datang lebih awal ke sekolah.
Implementasi Seni Gerak Dan Lagu Dalam Membentuk Karakter Anak Usia 4-5 Tahun Di PAUD Kemala Bhayangkari
Authors:   Universitas Khairun, Taib Bahran , Samad Rita , Oktaviani Winda , Irham Meisar
Published: November 2022

Pendidikan Anak Usia Dini dapat diselengggarakan melalui jalur pendidikan formal, non formal, informal. Pendidikan Anak Usia Dini merupakan salah satu bentuk penyelenggaraan pendidikan yang menitik beratkan pada peletakan dasar kearah pertumbuhan dan enam aspek perkembangan. Tujuan dari penelitian ini untuk mengetahui bentuk implementasi seni gerak dan lagu dalam membentuk karakter anak di PAUD Kemala Bhayangkari Kota Ternate. Metode yang digunakan ialah kualitatif deskriptif tekhnik yang digunakan wawancara dan dokumentasi. Subjek penelitian dalam penelitian ini adalah para guru dan anak yang berada di PAUD Kemala Bhayangkari Kota Ternate. Hasil penelitian menunjukan bahwa pembentukan karakter dapat di lakukan melalui banyak hal seperti melalui sikap mandiri, kreatif dan rasa tanggung jawab yang mulai di biasakan dalam diri anak melalui proses pembelajran seni gerak dan lagu. 1) Mandiri melatih anak dalam sikap kemadirian yang mana anak di ajarkan agar dapat melakukan gerakan dan lagu sendiri. Melatih sikap kepercayaan dirinya dalam melakukan gerakan dan lagu. 2) Guru melatih kreatifitas anak dalam hal seni gerak dan lagu dalam pembentukan karakter, dimana anak melakukan gerakan-gerakan yang unik yang di buat sendiri oleh ibu guru kemudian di gabungkan dengan musik dan lagu. 3) Rasa tanggung jawab yang di miliki anak dalam mengikuti semua proses pembelajaran yang di perintahkan oleh ibu guru selama proses pembeajaran seni gerak dan lagu.
MENINGKATKAN KEMAMPUAN BAHASA ANAK USIA 3-4 TAHUN MELALUI PERMAINAN TELEPON KALENG SEBAGAI MEDIA PEMBELAJARAN DI KELOMPOK A PAUD NEGERI PEMBINA 1 KOTA TERNATE
Authors:   Universitas Khairun, Arfa Umikalsum , Agustan Arifin Andi , Abdurahman Novianti
Published: November 2022

Penelitian ini bertujuan untuk mengetahui peningkatan perkembangan bahasa anak melalui telepon kaleng pada kelompok A PAUD Negeri Pembina 1 Kota Ternate. Jenis penelitian ini adalah penelitian tindakan kelas (PTK) yang terdiri dari dua siklus yang setiap siklusnya terdapat empat tahap yaitu perencanaan, pelaksanaan, observasi dan refleksi. Subjek penelitian adalah anak kelompok A PAUD Negeri pembina 1 kota ternate yang berjumlah 15 anak terdiri dari 9 anak laki-laki dan 6 anak perempuan. Teknik pengumpulan data menggunakan observasi, wawancara dan dokumentasi. Hasil penelitian menunjukan bahwa kemampuan bahasa anak berkembang sangat baik. Hal ini dapat dilihat dari kemampuan awal bahasa anak dari 15 siswa di kelas A yang memberikan hasil belum berkembang (BB) yaitu 40%, mulaiberkembang (MB) yaitu 27%, berkembang sangat baik (BSB) yaitu 20%, dan berkembang sesuai harapan 13%. Pada siklus 1, belum berkembang (BB) yaitu 13%, mulai berkembang (MB) 13%,berkembang sangat baik (BSB) yaitu 33%, dan berkembang sesuai harapan (BSH) yaitu 40%. Sedangkan pada siklus II, belum berkembang (BB)yaitu 0%, mulai berkembang (MB) yaitu 7%,berkembang sangat baik (BSB) yaitu 27%, dan berkembang sesuai harapan (BSH) yaitu 67%.
[Final accepted version, unedited] Exploring the inhibitory mechanisms of indazole compounds against SAH/MTAN-mediated quorum sensing utilizing QSAR and docking
Authors: Nandi Sisir , Kumar Mohit , Kumari Rashmi , Saxena Aaruni
Published: November 2022

The world is under the great threat of antimicrobial resistance (AMR) leading to premature deaths. Micro-organisms can produce AMR via quorum sensing mechanisms utilizing S-adenocylhomocystiene/methiothioadenosine nucleosidase (SAH/MTAN) biosynthesis. But there is no specific drug developed till date to stop theSAH/MTAN which is a crucial target for the discovery of anti quorum sensing compound. It has been shown that the indazole compounds causes inhibition of SAH/MTA nucleosidase mediated quorum sensing, but the biochemical mechanisms have not yet been explored.Therefore, in this original research, an attempt has been made to explore essential structural features of these compounds by QSAR and molecular docking of indazole compounds having inhibition of SAH/MTA nucleosidase mediated quorum sensing. The validated QSAR predicted five essential descriptors and the molecular docking helps to identify the active binding amino acid residues involved in ligand receptor interaction are responsible for producing the quorum sensing inhibitory mechanisms of indazole compounds against SAH/MTAN-mediated antimicrobial resistance.
Narrative Review of Pathophysiology and Endoscopic Management of Basivertebral and Sinuvertebral Neuropathy for Chronic Back Pain
Authors: Kim Hyeun Sung , Wu Pang Hung , Jang Il-Tae
Published: November 2022

Chronic lower back pain is a leading cause of disability in musculoskeletal system. Degenerative disc disease is one of the main contributing factor of chronic back pain in the aging population in the world. It is postulated that sinuvertebral nerve and basivertebral nerve main mediator of the nociceptive response in degenerative disc disease as a result of neurotization of sinuvertebral and basivertebral nerve. A review in literature is done on the pathoanatomy, pathophysiology and pain generation pathway in degenerative disc disease and chronic back pain and management strategy is discussed in this review to aid understanding of sinuvertebral and basivertebral neuropathy treatment strategies.
Measuring left-behind children’s discrimination perception in China: the development of discrimination perceptions of left-behind children Scale
Authors:   1 Institute of Special Education, Faculty of Education, Beijing Normal University, Beijing, 100875, China, Fu Wangqian , Tang Wenjun ,   2 Changsha Institute of Educational Science, Changsha, 410000, China., Zhang Lei ,   Department of Ideological and Political, Beijing Health Vocational College, Beijing, 101101, China
Published: November 2022

With the advancement of urbanization in China, there are millions left-behind children whose parents left home to support families, experiencing lot of discrimination. The study aims to develop a scale measuring left-behind children’s discrimination perceptions (discrimination perceptions of left-behind children, DPLC) in China and investigate the discrimination perceptions of left-behind children using the DPLC scale. The data for 105 left-behind children were used to measure the reliability and analyze the items of the DPLC scale in the pre-test. The data for 402 left-behind children were used to verify the construct validity and internal consistency of the DPLC scale and investigate children’ discrimination perceptions of left-behind in China. This study reports the development process of the DPLC scale and presents a valid scale for measuring discrimination perceptions of left-behind in the future.
Sub-lethal and lethal effects of chronic and extreme multiple stressors on a critical New Zealand bivalve under hypoxia
Authors: Salmond NH , Wing SR
Published: November 2022

Warming of coastal regions due to climate change is exerting chronic thermal stress on intertidal organisms, many of which are already living at or near their limits for thermal tolerance. In addition, increasing frequency of marine heat waves and algal blooms leading to hypoxic events in estuaries exert acute stresses on aerobic organisms. Hypoxia and warming rarely occur in isolation, and when combined, likely have synergistic detrimental effects on bivalves. Further, midday low tides have been identified as important drivers of mass mortality events for bivalves as a consequence of the combined effects of thermal stress and desiccation. Accordingly, the current study focuses on the sublethal and lethal effects of these combined stressors on the critical estuarine bivalve Austrovenus stutchburyi. Experiments were used to test the effects of simulated midday low tides combined with chronic warming and oxygen depletion on activity, respiration and survival of A. stutchburyi. A lethal emersion thermal threshold was surpassed at 33°C for treatments exposed to both hypoxic and normoxic treatments, suggesting extreme thermal events such as heatwaves during midday low tides could have substantial detrimental effects on bivalve populations and their vital ecosystem functions. Further, the ability of bivalves to survive heat and desiccation of midday low tide events was much reduced when they were exposed to even minor heat and hypoxia stress when immersed at high tide. The findings of the current study highlight important biological consequences of coastal warming combined with extreme temperature and hypoxic events observed in estuaries.
Discrepancies in Nanoindentation Hardness and Modulus with a Berkovich, a Cube-corner, and a Conical Tip in a Cu(In,Ga)Se2 Light-Absorption Layer
Authors: Kang Yeojin , Park Wonjung , Zhang Mao , Yoo Dayoung , Lee Dongyun
Published: November 2022

In this study, we tried to understand the difference in the mechanical properties (elastic modulus, E & hardness, H) values of CIGS compound semiconductors measured using the Berkovich indenter and the sharper cube corner and conical indenter. Adopted continuous stiffness measurement technique to characterize it along with the indentation depth. The depth was up to 1000 nm, and E and H values w ere obtained according to the depth. The projected contact area of the cube edge and the conical indenter was calculated assuming the two indenters had an ideal shape. In the case of the Berkovich indenter, which is the subject of comparison, both calculated values assuming an ideal shape and experimental values were used. Cube-corner and conical tip showed lower load at the same depth of 1000 nm compared to Berkovich indenter. This means that the same depth of indentation was achieved even at a low load, which could affect the value of the mechanical properties of the thin film. The cube-corner tip and the conical tip have a sharp shape with a projected contact area about 6 times smaller than that of the Berkovich tip. It was observed that not only the effect of grain boundaries of the microstructure of the CIGS thin film, but also the effect of reflecting the characteristics of the Mo substrate had a significant effect on the mechanical properties of the CIGS thin film.
A CASE OF ACUTE CORONARY SYNDROME UNDER IMMUNSUPRESSION WHO IS THE CRIMINAL NEUTROPHILS OR T CELLS?
Authors: Oktay İrem , Sertdemir Ahmet Lütfü , İçli Abdullah
Published: November 2022

Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by recurrent, life-threatening bacterial and fungal infections of the skin, airways, lymph nodes, liver, brain, and bones. These infections most commonly occur in organs in contact with the outside world (lungs, gastrointestinal tract, and skin), as well as in lymph nodes that drain these structures. While involvement can be seen in many organs, there is no known cardiovascular involvement. Our case is an ACS case that has a different place in the literature because acute coronary syndrome (ACS) was seen in a 20-year-old male patient with a diagnosis of chronic granulomatous disease.
An unusual pediatric monteggia equivalent lesion: a rare case report
Authors: Çelik Metin , Arıkan Emre , Yılmaz Ömer Faruk
Published: November 2022

Abstract: Monteggia lesion is a rare fracture in which ulna shaft fracture and radial head dislocation occur together. Monteggia equivalent is the lesion associated with ulna shaft fracture and radius head and/or neck fracture. We offer a case of Monteggia equivalent in a 9-years-old boy. In the surgery of the patient, anatomical plating was performed for ulna shaft fracture and intramedullary nail was applied for radius neck fracture. When we look at the literature, such case reports are very rare.
Conclusion: In the 1-year follow-up of the patient, there was no loss in flexion, extension, supination and pronation range of motion.
RNAi-based pest control: Production, application and the fate of dsRNA
Authors: He Li , Huang Yanna , Tang Xueming
Published: November 2022

The limitations of conventional pesticides have raised the demand for innovative and sustainable solutions for plant protection. RNA Interference (RNAi) triggered by dsRNA has evolved as a promising strategy to control insects in a species-specific manner. In this context, we review the methods for mass production of dsRNA, the approaches of exogenous application of dsRNA in the field, and the fate of dsRNA after application. Additionally, we describe the opportunities and challenges of using nanoparticles as dsRNA carriers to control insects. Furthermore, we provide future directions to improve pest management efficiency by utilizing the synergistic effects of multiple target genes. Meanwhile, the establishment of a standardized framework for assessment and regulatory consensus is critical to the commercialization of RNA pesticides.
Membrane distillation crystallization for water and mineral recovery: The occurrence of fouling and its control during wastewater treatment
Authors: Chimanlal Indira , Nthunya Lebea N. , Quist-Jensen Cejna , Richards Heidi
Published: November 2022

Membrane distillation crystallization (MDC) is an emerging technology envisaged to manage challenges affecting the desalination industry. This technology can sustainably treat concentrated solutions of produced water and industrially discharged saline wastewater. Simultaneous recovery of clean water and minerals is achieved through the integration of crystallization to membrane distillation (MD). MDC has received vast research interest because of its potential to treat hypersaline solutions. However, MDC still faces challenges in harnessing its industrial applications. Technically, MDC is affected by fouling/scaling and wetting thereby hindering practical application at the industrial level. This study reviews the occurrence of membrane fouling and wetting experienced with MDC. Additionally, existing developments carried out to address these challenges are critically reviewed. Finally, prospects suggesting the sustainability of this technology are highlighted.
Negotiation-based cooperative planning of local trajectories
Authors: Schneider Julian , Rothfuß Simon , Hohmann Sören
Published: November 2022

In this work, a cooperative local trajectory planner based on negotiation theory for human‐robot interaction is developed. It is implemented on a robot, which accompanies patients to examination rooms as part of the HoLLiECares project. For this purpose, an existing human–machine cooperation model for decision-making in one-time conflict cases is applied to a time-repeated negotiation of motion primitives. In negotiation theory, time pressure in the form of deadlines is classically used to achieve agreements. Since deadlines do not naturally exist in all technical applications and their artificial insertion would create an unintuitive system behavior for an involved human, a reciprocal tit-for-tat strategy for the automation is applied in the present work to achieve agreements. This leads to a system behavior that is able to dynamically change between human-in-the-lead behavior or automation-in-the-lead behavior and everything in between depending on the concession of the human and thus on human’s desire. The cooperative negotiation-based local trajectory planner is tested simulatively.
Geno- and phenotypic characteristics and clinical outcomes of CACNA1C gene mutation associated Timothy syndrome, “cardiac only” Timothy syndrome and isolated long QT syndrome 8: A systematic review
Authors: Borbás János , Vámos Máté , Hategan Lidia , Hanák Lilla , Farkas Nelli , Szakács Zsolt , Csupor Dezső , Tél Bálint , Kupó Péter , Csányi Beáta , Nagy Viktória , Komócsi András , Habon Tamás , Hegyi Péter , Sepp Róbert
Published: November 2022

Background

Mutations in the CACNA1C gene–encoding for the major Ca2+ channel of the heart–may exhibit a variety of clinical manifestations. These include typical or atypical Timothy syndromes (TS) which are associated with multiple organ manifestations, and cardiac involvement in form of malignant arrhythmias, QTc prolongation, or AV block. “Cardiac only” Timothy syndrome (COTS) shows no extracardiac manifestation, whereas some CACNA1C gene mutations are associated with QTc prolongation alone (isolated long QT syndrome 8, LQT8).

Methods

A systematic search of the literature reporting cases of CACNA1C gene mutation associated syndromes, including TS, COTS and isolated LQT8 via major databases published from 2004 through 2019 was performed. Detailed patient-level phenotypic and genotypic characteristics, as well as long-term outcome measures were collected and compared between pre-specified patient groups, defined both on phenotype and genotype.

Results

A total of 59 TS, 6 COTS, and 20 isolated LQT8 index cases were identified. Apart of syndactyly or baldness, there were no major differences regarding clinical manifestations or outcome measures between TS subtypes, either defining TS subtypes on the genotype or based on the phenotype. Both subtypes were characterized by an extreme degree of QTc prolongation (median ≥600 ms) which were reflected in high major adverse cardiac event rate. On the other hand, there were marked differences between TS, COTS, and isolated LQT8. Timothy syndrome was characterized by a much earlier disease onset, much more pronounced QTc prolongation and much higher mortality rate than COTS or isolated LQT8. Similar differences were observed comparing CACNA1C exon 8/8A vs. non-exon 8/8A mutation carriers. TS showed a high degree of genetic homogeneity, as the p.Gly406Arg mutation either in exon 8 or exon 8A alone was responsible for 70% of the cases.

Conclusions

Clinical phenotypes associated with mutations in the CACNA1C gene show important clinical differences. Timothy syndrome is associated with the most severe clinical phenotype and with the highest risk of morbidity and mortality. However, distinguishing TS subtypes, in any form, are not supported by our data.

Systematic review registration

[https://www.crd.york.ac.uk/prospero/], identifier [CRD42020184737].
ASK120067 (limertinib) exerts pre-clinical anti-tumor activity by inhibiting EGFR exon20 insertion
Authors: Zhang Tao , Feng Fang , Tong Linjiang , Chan Shingpan , Chen Yi , Li Yan , Song Peiran , Liu Yingqiang , Bai Gang , Lai Mengzhen , Ning Yi , Wang Yanan , Fang Yan , Pan Zilu , Geng Meiyu , Ding Ke , Ding Jian , Xie Hua
Published: November 2022

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are classic strategies for the individualized treatment for patients with non-small cell lung cancer (NSCLC). However, EGFR exon20 insertion (EGFR 20ins) mutations, accounting for 6%–12% of all EGFR mutant cases in NSCLC, are generally resistant to the reversible EGFR TKIs (such as gefitinib and erlotinib), which makes them challenging drug-targets in lung cancer. In our previous study, we identified ASK120067 (limertinib) as a novel 3rd-generation EGFR TKI targeting EGFR T790M mutation with promising clinical activities. Here, we accessed the potency of ASK120067 on EGFR 20ins activation and evaluated its in vitro and in vivo anti-tumor activity against EGFR 20ins driven tumor models. We found that ASK120067 showed potent inhibitory activity on TKI-resistant EGFR 20ins kinase. In TKI-resistant EGFR 20ins-dependent BaF3 cells, it dose-dependently suppressed EGFR phosphorylation, impeded cell proliferation, and induced cell apoptosis with much superior efficacy to gefitinib and erlotinib. Moreover, oral administration of ASK120067 decreased the level of phospho-EGFR 20ins and caused significant tumor regression in EGFR 20ins BaF3 xenograft model. These results presented the pre-clinical anti-tumor efficacy of ASK120067 in EGFR 20ins models and highlighted the potential value of ASK120067 for the treatment of NSCLC patients harboring EGFR 20ins mutations.