bluuebunny/crossref_metadata_2025 huggingface dataset:
Sol-Gel-Assisted Microwave-Derived Synthesis of Anatase Ag/TiO2/GO Nanohybrids toward Efficient Visible Light Phenol Degradation
Authors: Alsharaeh E. H. , Bora T. , Soliman A. , Ahmed Faheem , Bharath G. , Ghoniem M. G. , Abu-Salah Khalid M. , Dutta J.
Published: May 2017

Abstract: A simple microwave-assisted (MWI) wet chemical route to synthesize pure anatase phase titanium dioxide (TiO2) nanoparticles (NPs) is reported here using titanium tetrachloride (TiCl4) as starting material. The as-prepared TiO2 NPs were characterized by electron microscopy, X-ray diffraction, UV/visible absorption spectroscopy, and infrared and Raman spectroscopic techniques. Further modification of the anatase TiO2 NPs was carried out by incorporating plasmonic silver (Ag) NPs and graphene oxide (GO) in order to enhance the visible light absorption. The photocatalytic activities of the anatase TiO2, Ag/TiO2, and Ag/TiO2/GO nanocomposites were evaluated under both ultraviolet (UV) and visible light irradiation using phenol as a model contaminant. The presence of Ag NPs was found to play a significant role to define the photocatalytic activity of the Ag/TiO2/GO nanocomposite. It was found that the Ag performed like a sink under UV excitation and stored photo-generated electrons from TiO2, whereas, under visible light excitation, the Ag acted as a photosensitizer enhancing the photocatalytic activity of the nanocomposite. The detailed mechanism was studied based on photocatalytic activities of Ag/TiO2/GO nanocomposites. Therefore, the as-prepared Ag/TiO2/GO nanocomposite was used as photocatalytic materials under both UV and visible light irradiation toward degradation of organic molecules.
An Evaluation of a Continuing Education Program for Family Caregivers of Ventilator-Dependent Children with Spinal Muscular Atrophy (SMA)
Authors: Boroughs Deborah
Published: May 2017

Until 25 years ago, there were limited options for long-term mechanical ventilation of children, and the majority of children were cared for in hospitals. However, with improving technology, the pediatric intensive care unit has moved from the hospital to a home setting, as children with increasingly complex healthcare needs are now often cared for by family members. One of the most complex care conditions involves ventilator and tracheostomy support. Advanced respiratory technologies that augment natural respiratory function prolong the lives of children with respiratory compromise; however, this care often comes with serious risks, including respiratory muscle impairment, respiratory failure, and chronic pulmonary disease. Both non-invasive assisted ventilation and assisted ventilation via tracheostomy can prolong survival into adulthood in many cases; however, mechanical ventilation in the home is a high-stakes, high risk intervention. Increasing complexity of care over time requires perpetual skill training of family caregivers that is delivered and supported by professional caregivers; yet, opportunities for additional training outside of the hospital rarely exist. Recent data has confirmed that repetitive caregiver education is essential for retention of memory and skills in adult learners. This study analyzes the use of continued education and training in the community for family caregivers of ventilator-dependent children diagnosed with spinal muscular atrophy (SMA).
Kinetics of Interactions of Matter, Antimatter and Radiation Consistent with Antisymmetric (CPT-Invariant) Thermodynamics
Authors: Klimenko A.Y.
Published: May 2017

This work investigates the influence of directional properties of decoherence on kinetics rate equations. The physical reality is understood as a chain of unitary and decoherence events. The former are quantum-deterministic, while the latter introduce uncertainty and increase entropy. For interactions of matter and antimatter, two approaches are considered: symmetric decoherence, which corresponds to conventional symmetric (CP-invariant) thermodynamics, and antisymmetric decoherence, which corresponds to antisymmetric (CPT-invariant) thermodynamics. Radiation, in its interactions with matter and antimatter, is shown to be decoherence-neutral. The symmetric and antisymmetric assumptions result in different interactions of radiation with matter and antimatter. The theoretical predictions for these differences are testable by comparing absorption (emission) of light by thermodynamic systems made of matter and antimatter. Canonical typicality for quantum mixtures is briefly discussed in Appendix A.
Research on Partial Discharge Source Localization Based on an Ultrasonic Array and a Step-by-Step Over-Complete Dictionary
Authors: Gao Shuguo , Zhang Ying , Xie Qing , Kan Yuqiang , Li Si , Liu Dan , Lü Fangcheng
Published: May 2017

Partial discharge (PD) in electrical equipment is one of the major causes of electrical insulation failures. Fast and accurate positioning of PD sources allows timely elimination of insulation faults. In order to improve the accuracy of PD detection, this paper mainly studies the direction of arrival (DOA) estimation of PD ultrasonic signals based on a step-by-step over-complete dictionary. The simulation results show that the step by step dictionary can improve the operation speed and save signal processing time. Firstly, a step-by-step over-complete dictionary covering all the angles of space is established according to the expression of the steering vector for a matching pursuit direction finding algorithm, which can save computation time. Then, the step-by-step complete dictionary is set up according to the direction vector, and the atomic precision is respectively set to 10°, 1° and 0.1°. The matching pursuit algorithm is used to carry out the sparse representation of the received data X and select the optimal atom from the step-by-step complete dictionary, and the angle information contained in atoms is DOA of the PD sources. According to the direction finding results, combined with the installation location of the ultrasonic array sensor, the spatial position of a partial discharge source can be obtained using the three platform array location method. Finally, a square ultrasonic array sensor is developed, and an experimental platform for the ultrasonic array detection of partial discharges is set up and used to carry out an experimental study. The results show that the DOA estimation method based on a step-by-step over-complete dictionary can improve the direction finding precision, thereby increasing the subsequent positioning accuracy, and the spatial position estimation error of the PD source obtained under laboratory conditions is about 5 cm, making this a feasible method.
Experimental and Theoretical Study of the Interactions between Fe2O3/Al2O3 and CO
Authors: Liang Zhiyong , Qin Wu , Dong Changqing
Published: May 2017

The behavior of Fe2O3/Al2O3 particles as oxygen carriers (OCs) for CO chemical looping combustion (CLC) under different reaction temperatures (700 °C, 800 °C, 900 °C, and 1000 °C) were tested in a lab-scale fluidized bed and a thermogravimetric analysis (TGA) unit. The results show that the oxygen carrier presents the highest reactivity at 800 °C, even after 30 cycles of redox reaction in a fluidized bed, while more obvious carbon deposition occurred for the case at 700 °C, and agglomeration for the case at 1000 °C. Moreover, the detailed behavior of the prepared Fe2O3/Al2O3 particle was detected in the TGA apparatus at different reaction temperatures. Furthermore, temperature-programming TGA experiments were performed to investigate the influence of different CO concentrations and CO/CO2 concentrations on the reaction between CO and OC during the chemical looping combustion processes. Based on these experimental behaviors of the prepared Fe2O3/Al2O3 during the CLC of CO, the detailed models and electronic properties of the pure and reduced Fe2O3/Al2O3 supported the slabs, CO adsorption, and oxidation, and the decomposition reactions on these surfaces were revealed using density functional theory (DFT) calculations which went deep into the nature of the synergetic effect of the support of Al2O3 on the activity of Fe2O3 for the CLC of CO.
The Effect of Solvents on the Performance of CH3NH3PbI3 Perovskite Solar Cells
Authors: Huang Pao-Hsun , Wang Yeong-Her , Ke Jhong-Ciao , Huang Chien-Jung
Published: May 2017

The properties of perovskite solar cells (PSCs) fabricated using various solvents was studied. The devices had an indium tin oxide (ITO)/poly(3,4-ethylenedioxythiophene): poly(styrenesulfonate) (PEDOT:PSS)/CH3NH3PbI3 (fabricated by using various solvents)/fullerene (C60)/bathocuproine (BCP)/silver (Ag) structure. The solvents used were dimethylformamide (DMF), γ-butyrolactone (GBL), dimethyl sulfoxide (DMSO), a mixture of DMSO and DMF (1:1 v/v), and a mixture of DMSO and GBL (DMSO: GBL, 1:1 v/v), respectively. The power conversion efficiency (PCE) of the device fabricated using DMF is zero, which is attributed to the poor coverage of CH3NH3PbI3 film on the substrate. In addition, the PCE of the device made using GBL is only 1.74% due to the low solubility of PbI2 and CH3NH3I. In contrast, the PCE of the device fabricated using the solvents containing DMSO showed better performance. This is ascribed to the high solubilization properties and strong coordination of DMSO. As a result, a PCE of 9.77% was obtained using a mixed DMSO:GBL solvent due to the smooth surface, uniform film coverage on the substrate and the high crystallization of the perovskite structure. Finally, a mixed DMSO: DMF:GBL (5:2:3 v/v/v) solvent that combined the advantages of each solvent was used to fabricate a device, leading to a further improvement of the PCE of the resulting PSC to 10.84%.
Statistical Feature Extraction for Fault Locations in Nonintrusive Fault Detection of Low Voltage Distribution Systems
Authors: Chang Hsueh-Hsien , Linh Nguyen Viet
Published: May 2017

This paper proposes statistical feature extraction methods combined with artificial intelligence (AI) approaches for fault locations in non-intrusive single-line-to-ground fault (SLGF) detection of low voltage distribution systems. The input features of the AI algorithms are extracted using statistical moment transformation for reducing the dimensions of the power signature inputs measured by using non-intrusive fault monitoring (NIFM) techniques. The data required to develop the network are generated by simulating SLGF using the Electromagnetic Transient Program (EMTP) in a test system. To enhance the identification accuracy, these features after normalization are given to AI algorithms for presenting and evaluating in this paper. Different AI techniques are then utilized to compare which identification algorithms are suitable to diagnose the SLGF for various power signatures in a NIFM system. The simulation results show that the proposed method is effective and can identify the fault locations by using non-intrusive monitoring techniques for low voltage distribution systems.
Grain Size Distribution Effect on the Hydraulic Properties of Disintegrated Coal Mixtures
Authors: Ma Dan , Zhou Zilong , Wu Jiangyu , Li Qiang , Bai Haibo
Published: May 2017

In order to better understand groundwater influx and protection in coal mining extraction works, an in-house water flow apparatus coupled with an industrial rock testing system, known as MTS 815.02, were used to study the effects of grain size mixtures on the compaction and flow properties of disintegrated, or non-cemented, coal samples. From the Reynolds number evaluation of the samples with different grain mixtures, and the relationship between the water flow velocity and pore pressure gradient differences, it was found that seepage through the mixtures are of non-Darcy flow type. The porosity of coal specimens was found to be highly affected by compaction, and the variations of the porosity were also influenced by the samples’ grain size distribution. It was found that the sample porosity decreases with increasing compaction and decreasing grain sizes. Grain crushing during compaction was observed to be the main cause of the appearance of fine grains, and the washing away of fine grains was consequently the main contributing factor for the weight loss due to water seepage. It was observed that during the tests and with the progression of compaction, permeability k decreases and non-Darcy factor β increases with decreasing porosity φ. The k-φ and β-φ plots show that as the sizes of disintegrated coal samples are getting smaller, there are more fluctuations between the porosity values with their corresponding values of k and β. The permeability value of the sample with smallest grains was observed to be considerably lower than that of the sample with largest grains. Non-Darcy behavior could reduce the hydraulic conductivity. It was found that the porosity, grain breakage and hydraulic properties of coal samples are related to grain sizes and compaction levels, as well as to the arrangement of the grains. At high compaction levels, the porosity of disintegrated coal samples decreased strongly, resulting in a significant decrease of the permeability at its full compression state; Non-Darcy flow behavior has the slightest effect in uniform samples, therefore, indicating that disintegrated coal in uniform grain size mixtures could be treated as an aquicluding (water-resisting) stratum.
Stakeholder Participation in REDD+ Readiness Activities for Three Collaborative Projects in Lao PDR
Authors: Boutthavong Saykham , Hyakumura Kimihiko , Ehara Makoto
Published: May 2017

A key challenge for reducing emission from deforestation and forest degradation (REDD) in developing countries is to balance the power of various stakeholders in decision making. This study explores the forms of stakeholder participation in the implementation of three pilot projects in Laos, with a focus on who actually makes decisions on project activities. We found that stakeholder roles in making decisions were imbalanced. The central government and development partner organizations were the ones who actually fulfill the roles of decision-makers in most project activities. Although local communities were not the key stakeholders in decision making in most activities, their roles seem to have increased in the activities where participatory approaches were applied. Participation of the private sector, non-governmental organizations, academic and research institutes and mass organizations was limited. Opportunities to reach decision-makers regarding project activities came through service contract agreements. Our findings suggest that an understanding of who fulfills the key roles will support a decentralization of decision making by balancing power and redistributing the roles from dominant to weaker stakeholders. In addition, the private sector’s participation may enhance opportunities to harmonize their investments for supporting REDD+ development and reduce the negative impacts on the forests and the environment.
Accuracy of Photogrammetric UAV-Based Point Clouds under Conditions of Partially-Open Forest Canopy
Authors: Tomaštík Julián , Mokroš Martin , Saloň Šimon , Chudý František , Tunák Daniel
Published: May 2017

This study focuses on the horizontal and vertical accuracy of point-clouds based on unmanned aerial vehicle (UAV) imagery. The DJI Phantom 3 Professional unmanned aerial vehicle and Agisoft PhotoScan Professional software were used for the evaluation. Three test sites with differing conditions (canopy openness, slope, terrain complexity, etc.) were used for comparison. The accuracy evaluation was aimed on positions of points placed on the ground. This is often disregarded under forest conditions as it is not possible to photogrammetrically reconstruct terrain that is covered by a fully-closed forest canopy. Therefore, such a measurement can only be conducted when there are gaps in the canopy or under leaf-off conditions in the case of deciduous forests. The reported sub-decimetre horizontal accuracy and vertical accuracy lower than 20 cm have proven that the method is applicable for survey, inventory, and various other tasks in forests. An analysis of ground control point (GCP) quantity and configuration showed that the quantity had only a minor effect on the accuracy in cases of plots with ~1-hectare area when using the aforementioned software. Therefore, methods increasing quality (precision, accuracy) of GCP positions should be preferred over the increase of quantity alone.
Microsporogenesis and Induction of Unreduced Pollen with High Temperatures in Rubber Tree Clone RRIM 600
Authors: Yao Peng-Qiang , Li Guo-Hua , Long Qing-Yi , He Li-Gang , Kang Xiang-Yang
Published: May 2017

In order to induce unreduced pollens, microsporogenesis and male flower bud (MFB) development were compared in rubber tree clone RRIM 600. We observed strong asynchronism in different MFBs in an inflorescence. Asynchronism of microsporogenesis in different microsporangiums from a MFB was also observed. The relationship between microsporogenesis and external morphology was examined, which was used to estimate microsporogenesis stages of MFBs. Unreduced pollen was successfully induced by high temperature exposure in this study, with the highest production ratio of about 20.17% at 44 °C. Our findings showed that diplotene to metaphase I may be the most effective stage for unreduced pollen induction, and 42–44 °C may be the suitable treatment temperature in rubber trees. Thus, microsporogenesis of MFBs has been elucidated in detail in the rubber tree clone RRIM 600 and will provide a reference for future breeding studies of rubber trees.
Care-Seeking Patterns and Direct Economic Burden of Injuries in Bangladesh
Authors: Alfonso Yira Natalia , Alonge Olakunle , Hoque Dewan Md Emdadul , Ul Baset Md Kamran , Hyder Adnan , Bishai David
Published: May 2017

This study provides a comprehensive review of the care-seeking patterns and direct economic burden of injuries from the victims’ perspective in rural Bangladesh using a 2013 household survey covering 1.17 million people. Descriptive statistics and bivariate analyses were used to derive rates and test the association between variables. An analytic model was used to estimate total injury out-of-pocket (OOP) payments and a multivariate probit regression model assessed the relationship between financial distress and injury type. Results show non-fatal injuries occur to 1 in 5 people in our sample per year. With average household size of 4.5 in Bangladesh--every household has an injury every year. Most non-fatally injured patients sought healthcare from drug sellers. Less than half of fatal injuries sought healthcare and half of those with care were hospitalized. Average OOP payments varied significantly (range: $8–$830) by injury type and outcome (fatal vs. non-fatal). Total injury OOP expenditure was $355,795 and $5000 for non-fatal and fatal injuries, respectively, per 100,000 people. The majority of household heads with injuries reported financial distress. This study can inform injury prevention advocates on disparities in healthcare usage, OOP costs and financial distress. Reallocation of resources to the most at risk populations can accelerate reduction of preventable injuries and prevent injury related catastrophic payments and impoverishment.
A Comparison of Terrain Indices toward Their Ability in Assisting Surface Water Mapping from Sentinel-1 Data
Authors: Huang Chang , Nguyen Ba Duy , Zhang Shiqiang , Cao Senmao , Wagner Wolfgang
Published: May 2017

The Sentinel-1 mission provides frequent coverage of global land areas and is hence able to monitor surface water dynamics at a fine spatial resolution better than any other Synthetic Aperture Radar (SAR) mission before. However, SAR data acquired by Sentinel-1 also suffer from terrain effects when being used for mapping surface water, just as other SAR data do. Terrain indices derived from Digital Elevation Models (DEMs) are easy but effective approaches to reduce this kind of interference, considering the close relationship between surface water movement and topography. This study compares two popular terrain indices, namely the Multi-resolution Valley Bottom Flatness (MrVBF) and the Height Above Nearest Drainage (HAND), toward their performance on assisting surface water mapping using Sentinel-1 SAR data. Four study sites with different terrain characteristics were selected to cover a very wide range of topographic conditions. For two of these sites that are floodplain dominated, both normal and flooded scenarios were examined. MrVBF and HAND values for the whole study areas, as well as statistics of these values within water areas were compared. The sensitivity of applying different thresholds for MrVBF and HAND to mask out terrain effect was investigated by adopting quantity disagreement and allocation disagreement as the accuracy indicators. It was found that both indices help improve water mapping, reducing the total disagreement by as much as 1.6%. The HAND index performs slightly better in most of the study cases, with less sensitivity to thresholding. MrVBF classifies low-lying areas with more details, which sometimes makes it more effective in eliminating false water bodies in rugged terrain. It is therefore recommended to use HAND for large scale or global scale water mapping. However, for water detection in complex terrain areas, MrVBF also performs very well.
Multi-Objective Emergency Material Vehicle Dispatching and Routing under Dynamic Constraints in an Earthquake Disaster Environment
Authors: Jiang Jincheng , Li Qingquan , Wu Lixin , Tu Wei
Published: May 2017

Emergency material vehicle dispatching and routing (EMVDR) is an important task in emergency relief after large-scale earthquake disasters. However, EMVDR is subject to dynamic disaster environment, with uncertainty surrounding elements such as the transportation network and relief materials. Accurate and dynamic emergency material dispatching and routing is difficult. This paper proposes an effective and efficient multi-objective multi-dynamic-constraint emergency material vehicle dispatching and routing model. Considering travel time, road capacity, and material supply and demand, the proposed EMVDR model is to deliver emergency materials from multiple emergency material depositories to multiple disaster points while satisfying the objectives of maximizing transport efficiency and minimizing the difference of material urgency degrees among multiple disaster points at any one time. Furthermore, a continuous-time dynamic network flow method is developed to solve this complicated model. The collected data from Ludian earthquake were used to conduct our experiments in the post-quake and the results demonstrate that: (1) the EMVDR model adapts to the dynamic disaster environment very well; (2) considering the difference of material urgency degree, the material loss ratio is −10.7%, but the variance of urgency degree decreases from 2.39 to 0.37; (3) the EMVDR model shows good performance in time and space, which allows for decisions to be made nearly in real time. This paper can provide spatial decision-making support for emergency material relief in large-scale earthquake disasters.
The Effect of Metformin and GANT61 Combinations on the Radiosensitivity of Prostate Cancer Cells
Authors: Gonnissen Annelies , Isebaert Sofie , McKee Chad , Muschel Ruth , Haustermans Karin
Published: May 2017

The anti-diabetes drug metformin has been shown to have anti-neoplastic effects in several tumor models through its effects on energy metabolism and protein synthesis. Recent studies show that metformin also targets Hedgehog (Hh) signaling, a developmental pathway re-activated in several tumor types, including prostate cancer (PCa). Furthermore, we and others have shown that Hh signaling is an important target for radiosensitization. Here, we evaluated the combination of metformin and the Hh inhibitor GANT61 (GLI-ANTagonist 61) with or without ionizing radiation in three PCa cell lines (PC3, DU145, 22Rv1). The effect on proliferation, radiosensitivity, apoptosis, cell cycle distribution, reactive oxygen species production, DNA repair, gene and protein expression was investigated. Furthermore, this treatment combination was also assessed in vivo. Metformin was shown to interact with Hh signaling by inhibiting the effector protein glioma-associated oncogene homolog 1 (GLI1) in PCa cells both in vitro and in vivo. The combination of metformin and GANT61 significantly inhibited PCa cell growth in vitro and enhanced the radiation response of 22Rv1 cells compared to either single agent. Nevertheless, neither the growth inhibitory effect nor the radiosensitization effect of the combination treatment observed in vitro was seen in vivo. Although the interaction between metformin and Hh signaling seems to be promising from a therapeutic point of view in vitro, more research is needed when implementing this combination strategy in vivo.
Molecular Ghrelin System in the Pancreatic Acinar Cells: The Role of the Polypeptide, Caerulein and Sensory Nerves
Authors: Bonior Joanna , Ceranowicz Piotr , Gajdosz Ryszard , Kuśnierz-Cabala Beata , Pierzchalski Piotr , Warzecha Zygmunt , Dembiński Artur , Pędziwiatr Michał , Kot Michalina , Leja-Szpak Anna , Nawrot-Porąbka Katarzyna , Link-Lenczowski Paweł , Olszanecki Rafał , Bartuś Krzysztof , Jaworek Jolanta
Published: May 2017

Ghrelin (GHRL) is an endogenous ligand for the growth hormone secretagogue receptor (GHS-R). Experimental studies showed that GHRL protects the stomach and pancreas against acute damage, but the effect of GHRL on pancreatic acinar cells was still undetermined. Aim: To investigate the effect of GHRL and caerulein on the functional ghrelin system in pancreatic acinar cells taking into account the role of sensory nerves (SN). Methods: Experiments were carried out on isolated pancreatic acinar cells and AR42J cells. Before acinar cells isolation, GHRL was administered intraperitoneally at a dose of 50 µg/kg to rats with intact SN or with capsaicin deactivation of SN (CDSN). After isolation, pancreatic acinar cells were incubated in caerulein-free or caerulein containing solution. AR42J cells were incubated under basal conditions and stimulated with caerulein, GHRL or a combination of the above. Results: Incubation of isolated acinar cells with caerulein inhibited GHS-R and GHRL expression at the level of mRNA and protein in those cells. Either in rats with intact SN or with CDSN, administration of GHRL before isolation of acinar cells increased expression of GHRL and GHS-R in those cells and reversed the caerulein-induced reduction in expression of those parameters. Similar upregulation of GHS-R and GHRL was observed after administration of GHRL in AR42J cells. Conclusions: GHRL stimulates its own expression and expression of its receptor in isolated pancreatic acinar cells and AR42J cells on the positive feedback pathway. This mechanism seems to participate in the pancreatoprotective effect of GHRL in the course of acute pancreatitis.
Pan-Cancer Mutational and Transcriptional Analysis of the Integrator Complex
Authors: Federico Antonio , Rienzo Monica , Abbondanza Ciro , Costa Valerio , Ciccodicola Alfredo , Casamassimi Amelia
Published: May 2017

The integrator complex has been recently identified as a key regulator of RNA Polymerase II-mediated transcription, with many functions including the processing of small nuclear RNAs, the pause-release and elongation of polymerase during the transcription of protein coding genes, and the biogenesis of enhancer derived transcripts. Moreover, some of its components also play a role in genome maintenance. Thus, it is reasonable to hypothesize that their functional impairment or altered expression can contribute to malignancies. Indeed, several studies have described the mutations or transcriptional alteration of some Integrator genes in different cancers. Here, to draw a comprehensive pan-cancer picture of the genomic and transcriptomic alterations for the members of the complex, we reanalyzed public data from The Cancer Genome Atlas. Somatic mutations affecting Integrator subunit genes and their transcriptional profiles have been investigated in about 11,000 patients and 31 tumor types. A general heterogeneity in the mutation frequencies was observed, mostly depending on tumor type. Despite the fact that we could not establish them as cancer drivers, INTS7 and INTS8 genes were highly mutated in specific cancers. A transcriptome analysis of paired (normal and tumor) samples revealed that the transcription of INTS7, INTS8, and INTS13 is significantly altered in several cancers. Experimental validation performed on primary tumors confirmed these findings.
Effect of High Glucose Levels on White Adipose Cells and Adipokines—Fuel for the Fire
Authors: Sorisky Alexander
Published: May 2017

White adipocytes release adipokines that influence metabolic and vascular health. Hypertrophic obesity is associated with adipose tissue malfunctioning, leading to inflammation and insulin resistance. When pancreatic islet β cells can no longer compensate, the blood glucose concentration rises (hyperglycemia), resulting in type 2 diabetes. Hyperglycaemia may further aggravate adipose cell dysfunction in ~90% of patients with type 2 diabetes who are obese or overweight. This review will focus on the effects of high glucose levels on human adipose cells and the regulation of adipokines.
CIK Cells and HDAC Inhibitors in Multiple Myeloma
Authors: Stephan David , Weiher Hans , Schmidt-Wolf Ingo
Published: May 2017

Multiple myeloma is the second most common hematological malignancy. Despite all the progress made in treating multiple myeloma, it still remains an incurable disease. Patients are left with a median survival of 4–5 years. The combined treatment of multiple myeloma with histone deacetylase inhibitors and cytokine-induced killer cells provides a promising targeted treatment option for patients. This study investigated the impact of a combined treatment compared to treatment with histone deacetylase inhibitors. The experiments revealed that a treatment with histone deacetylase (HDAC) inhibitors could reduce cell viability to 59% for KMS 18 cell line and 46% for the U-266 cell line. The combined treatment led to a decrease of cell viability to 33% for KMS 18 and 27% for the U-266 cell line, thus showing a significantly better efficacy than the single treatment.
Association of Extracellular Membrane Vesicles with Cutaneous Wound Healing
Authors: Than Uyen Thi Trang , Guanzon Dominic , Leavesley David , Parker Tony
Published: May 2017

Extracellular vesicles (EVs) are membrane-enclosed vesicles that are released into the extracellular environment by various cell types, which can be classified as apoptotic bodies, microvesicles and exosomes. EVs have been shown to carry DNA, small RNAs, proteins and membrane lipids which are derived from the parental cells. Recently, several studies have demonstrated that EVs can regulate many biological processes, such as cancer progression, the immune response, cell proliferation, cell migration and blood vessel tube formation. This regulation is achieved through the release and transport of EVs and the transfer of their parental cell-derived molecular cargo to recipient cells. This thereby influences various physiological and sometimes pathological functions within the target cells. While intensive investigation of EVs has focused on pathological processes, the involvement of EVs in normal wound healing is less clear; however, recent preliminarily investigations have produced some initial insights. This review will provide an overview of EVs and discuss the current literature regarding the role of EVs in wound healing, especially, their influence on coagulation, cell proliferation, migration, angiogenesis, collagen production and extracellular matrix remodelling.
Hetero- and Homoleptic Magnesium Triazenides
Authors: Vinduš Denis , Niemeyer Mark
Published: May 2017

Using monoanionic triazenide ligands derived from biphenyl and m-terphenyl substituted triazenes Dmp(Tph)N3H (1a), (Me4Ter)2N3H (1b) or Dmp(Mph)N3H (1c) (Dmp = 2,6-Mes2C6H3 with Mes = 2,4,6-Me3C6H2; Me4Ter = 2,6-(3,5-Me2C6H3)2C6H3; Mph = 2-MesC6H4; Tph = 2-TripC6H4 with Trip = 2,4,6-i-Pr3C6H2), several magnesium triazenides were synthesized. Heteroleptic complexes [Mg(N3Ar2)I(OEt2)] (Ar2 = Dmp/Tph (2a), (Me4Ter)2 (2b) were obtained from metalation of the corresponding triazenes with di-n-butylmagnesium followed by reaction with iodine in diethyl ether as the solvent in high yields. Replacing diethyl ether by n-heptane afforded trinuclear compounds [Mg3(N3Ar2)2I4] (3a, 3b) in low yields in which a central MgI2 fragment is coordinated by two iodomagnesium triazenide moieties. Two unsolvated homoleptic magnesium compounds [Mg(N3Ar2)2] (4b, 4c) were obtained from di-n-butylmagnesium and triazenes 1b or 1c in a 1:2 ratio. Depending on the nature of the substituents, the magnesium center either shows the expected tetrahedral or a rather unusual square planar coordination.
The Role of a PMI-Prediction Model in Evaluating Forensic Entomology Experimental Design, the Importance of Covariates, and the Utility of Response Variables for Estimating Time Since Death
Authors: Wells Jeffrey , LaMotte Lynn
Published: May 2017

The most common forensic entomological application is the estimation of some portion of the time since death, or postmortem interval (PMI). To our knowledge, a PMI estimate is almost never accompanied by an associated probability. Statistical methods are now available for calculating confidence limits for an insect-based prediction of PMI for both succession and development data. In addition to it now being possible to employ these approaches in validation experiments and casework, it is also now possible to use the criterion of prediction performance to guide training experiments, i.e., to modify carrion insect development or succession experiment design in ways likely to improve the performance of PMI predictions using the resulting data. In this paper, we provide examples, derived from our research program on calculating PMI estimate probabilities, of how training data experiment design can influence the performance of a statistical model for PMI prediction.
Improved Methodology of Weather Window Prediction for Offshore Operations Based on Probabilities of Operation Failure
Authors: Gintautas Tomas , Sørensen John
Published: May 2017

The offshore wind industry is building and planning new wind farms further offshore due to increasing demand on sustainable energy production and already occupied prime resource locations closer to shore. Costs of operation and maintenance, transport and installation of offshore wind turbines already contribute significantly to the cost of produced electricity and will continue to increase, due to moving further offshore, if the current techniques of predicting offshore wind farm accessibility are to stay the same. The majority of offshore operations are carried out by specialized ships that must be hired for the duration of the operation. Therefore, offshore wind farm accessibility and costs of offshore activities are primarily driven by the expected number of operational hours offshore and waiting times for weather windows, suitable for offshore operations. Having more reliable weather window estimates would result in better wind farm accessibility predictions and, as a consequence, potentially reduce the cost of offshore wind energy. This paper presents an updated methodology of weather window prediction that uses physical offshore vessel and equipment responses to establish the expected probabilities of operation failure, which, in turn, can be compared to maximum allowable probability of failure to obtain weather windows suitable for operation. Two case studies were performed to evaluate the feasibility of the improved methodology, and the results indicated that it produced consistent and improved results. In fact, the updated methodology predicts 57% and 47% more operational hours during the test period when compared to standard alpha-factor and the original methodologies.
A Study of Efficiency Droop Phenomenon in GaN-Based Laser Diodes before Lasing
Authors: Feng Mei-Xin , Sun Qian , Liu Jian-Ping , Li Zeng-Cheng , Zhou Yu , Zhang Shu-Ming , Yang Hui
Published: May 2017

Carrier recombination behavior in c-plane GaN-based laser diodes (LDs) is numerically investigated by using the commercial software LASTIP. It is found that efficiency droop phenomenon does exist in GaN-based LDs before lasing, which is confirmed by experimental results. However, the current density corresponding to the peak efficiency of GaN-based LDs before lasing, Jmax, is nearly 40 A/cm2, which is much lower than that reported by other studies. The reported Jmax, measured from the cavity facet side is modulated by the absorption of quantum wells, which shifts the Jmax to a higher value. In addition, the currents due to various recombinations are calculated. It is found that Auger recombination affects the threshold current greatly, but it only plays a small role at high current injection levels.
Hydrogen Assisted Cracking in Pearlitic Steel Rods: The Role of Residual Stresses Generated by Fatigue Precracking
Authors: Toribio Jesús , Aguado Leticia , Lorenzo Miguel , Kharin Viktor
Published: May 2017

Stress corrosion cracking (SCC) of metals is an issue of major concern in engineering since this phenomenon causes many catastrophic failures of structural components in aggressive environments. SCC is even more harmful under cathodic conditions promoting the phenomenon known as hydrogen assisted cracking (HAC), hydrogen assisted fracture (HAF) or hydrogen embrittlement (HE). A common way to assess the susceptibility of a given material to HAC, HAF or HE is to subject a cracked rod to a constant extension rate tension (CERT) test until it fractures in this harsh environment. This paper analyzes the influence of a residual stress field generated by fatigue precracking on the sample’s posterior susceptibility to HAC. To achieve this goal, numerical simulations were carried out of hydrogen diffusion assisted by the stress field. Firstly, a mechanical simulation of the fatigue precracking was developed for revealing the residual stress field after diverse cyclic loading scenarios and posterior stress field evolution during CERT loading. Afterwards, a simulation of hydrogen diffusion assisted by stress was carried out considering the residual stresses after fatigue and the superposed rising stresses caused by CERT loading. Results reveal the key role of the residual stress field after fatigue precracking in the HAC phenomena in cracked steel rods as well as the beneficial effect of compressive residual stress.
A Reliable Turning Process by the Early Use of a Deep Simulation Model at Several Manufacturing Stages
Authors: Urbikain Gorka , Alvarez Alvaro , López de Lacalle Luis , Arsuaga Mikel , Alonso Miguel , Veiga Fernando
Published: May 2017

The future of machine tools will be dominated by highly flexible and interconnected systems, in order to achieve the required productivity, accuracy, and reliability. Nowadays, distortion and vibration problems are easily solved in labs for the most common machining operations by using models based on the equations describing the physical laws of the machining processes; however, additional efforts are needed to overcome the gap between scientific research and real manufacturing problems. In fact, there is an increasing interest in developing simulation packages based on “deep-knowledge and models” that aid machine designers, production engineers, or machinists to get the most out of the machine-tools. This article proposes a methodology to reduce problems in machining by means of a simulation utility, which uses the main variables of the system and process as input data, and generates results that help in the proper decision-making and machining plan. Direct benefits can be found in (a) the fixture/clamping optimal design; (b) the machine tool configuration; (c) the definition of chatter-free optimum cutting conditions and (d) the right programming of cutting toolpaths at the Computer Aided Manufacturing (CAM) stage. The information and knowledge-based approach showed successful results in several local manufacturing companies and are explained in the paper.
Thielavins W–Z7, New Antifouling Thielavins from the Marine-Derived Fungus Thielavia sp. UST030930-004
Authors: Han Zhuang , Li Yong-Xin , Liu Ling-Li , Lu Liang , Guo Xian-Rong , Zhang Xi-Xiang , Zhang Xiao-Yong , Qi Shu-Hua , Xu Ying , Qian Pei-Yuan
Published: May 2017

Eleven new depsides—thielavins W–Z (1–4) and thielavins Z1–Z7 (5–11)—and also four known thielavins—A, H, J, and K (12–15)—were isolated from the ethyl acetate extract of a marine-derived fungal strain Thielavia sp UST030930-004. All of these compounds were evaluated for antifouling activity against cyprids of the barnacle Balanus (=Amphibalanus) amphitrite. The results showed that compounds 1–3 and 6–13 were active, with EC50 values ranging from 2.95 ± 0.59 to 69.19 ± 9.51 μM, respectively. The inhibitive effect of compounds 1–3 and 7 was reversible. This is the first description of the antifouling activity of thielavins against barnacle cyprids.
Anti-Bacterial Activity of Phenolic Compounds against Streptococcus pyogenes
Authors: Macé Sabrina , Truelstrup Hansen Lisbeth , Rupasinghe H. P. Vasantha
Published: May 2017

Background: Worldwide, Streptococcus pyogenes is the leading cause of bacterial pharyngitis. To reduce the use of antibiotics, antimicrobial phytochemical-containing remedies, which have long been in use in traditional medicine, may provide new approaches for management of streptococcal pharyngitis. The objective of this study was to assess the inhibitory activities of 25 natural phenolic compounds against three strains of S. pyogenes. Methods: After an initial screening, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the nine most effective phenolic compounds were determined. The effect of four compounds with the lowest MIC and MBC on streptococcal growth and biofilm formation was also studied. Results: 1,2-Naphthoquinone and 5-hydroxy-1,4-naphthoquinone elicited the greatest anti-S. pyogenes activities with MICs ranging from 0.39 to 6.25 µg mL−1 and MBCs of 100 µg mL−1. Both naphthoquinones inhibited the biofilm formation at concentrations ranging from 12.5 to 50 µg mL−1. Biofilm reduction and altered bacterial cell structures were visible in scanning electron microscopy images of naphthoquinone-treated cells. Conclusion: In conclusion, 1,2-naphthoquinone and 5-hydroxy-1,4-naphthoquinone inhibit S. pyogenes and should be further investigated as candidates for the management of streptococcal pharyngitis.
Chemical Composition, Antimicrobial and Antioxidant Activities of Essential Oils from Two Avicennia schaueriana Stapf & Leechm. Ex Moldenke (Acanthaceae) Populations
Authors: Machado Kamilla N. , Kaneko Telma M. , Young Maria Cláudia M. , Murakami Cynthia , Cordeiro Inês , Moreno Paulo Roberto H.
Published: May 2017

Background: Avicennia schaueriana Stapf & Leechm. ex Moldenke (Acanthaceae) is a native species from the Brazilian mangroves presenting ecological and economic significance. This study compared the composition and the biological activities from the essential oils obtained from two A. schaueriana populations collected at Jureia-Itatins and Ilha do Cardoso. Methods: Essential oils were obtained by conventional means, and their compositions were analyzed by GC-MS. Screening assays for antimicrobial activity were carried out by the microdilution method and the antioxidant potential was assessed by the DPPH scavenging method. Results: The GC-MS analysis indicated that the Jureia oil (1) was composed mostly of the fatty acids palmitic (46.5%) and myristic (11.6%) acids, while the main components for the Ilha do Cardoso oil (2) were eugenol (19.7%), eugenol acetate (12.9%) and palmitic acid (15.1%). The oils showed an IC50 of 0.9 ± 0.011 mg/mL for 1 and 1.13 ± 0.028 mg/mL for 2 in the DPPH assay. The antimicrobial assay indicated MIC > 217 µg/mL for all tested microorganisms. Conclusions: The different essential oil composition may indicate the presence of chemotypes for A. schaueriana. The antioxidant activity of the oils was weak if compared with flavonoids. Despite the high MIC values, these oils presented some antibacterial potential against Pseudomonas aeruginosa.
Polymer Electrolyte Membranes for Water Photo-Electrolysis
Authors: Aricò Antonino , Girolamo Mariarita , Siracusano Stefania , Sebastian David , Baglio Vincenzo , Schuster Michael
Published: May 2017

Water-fed photo-electrolysis cells equipped with perfluorosulfonic acid (Nafion® 115) and quaternary ammonium-based (Fumatech® FAA3) ion exchange membranes as separator for hydrogen and oxygen evolution reactions were investigated. Protonic or anionic ionomer dispersions were deposited on the electrodes to extend the interface with the electrolyte. The photo-anode consisted of a large band-gap Ti-oxide semiconductor. The effect of membrane characteristics on the photo-electrochemical conversion of solar energy was investigated for photo-voltage-driven electrolysis cells. Photo-electrolysis cells were also studied for operation under electrical bias-assisted mode. The pH of the membrane/ionomer had a paramount effect on the photo-electrolytic conversion. The anionic membrane showed enhanced performance compared to the Nafion®-based cell when just TiO2 anatase was used as photo-anode. This was associated with better oxygen evolution kinetics in alkaline conditions compared to acidic environment. However, oxygen evolution kinetics in acidic conditions were significantly enhanced by using a Ti sub-oxide as surface promoter in order to facilitate the adsorption of OH species as precursors of oxygen evolution. However, the same surface promoter appeared to inhibit oxygen evolution in an alkaline environment probably as a consequence of the strong adsorption of OH species on the surface under such conditions. These results show that a proper combination of photo-anode and polymer electrolyte membrane is essential to maximize photo-electrolytic conversion.
Characterization of the Effect of Melt Treatments on Melt Quality in Al-7wt %Si-Mg Alloys
Authors: Uludağ Muhammet , Çetin Remzi , Dispinar Derya , Tiryakioğlu Murat
Published: May 2017

The effects of degassing, holding time and melt additions (Sr, Sr + Ti, Ti, B and B + Sr) on the quality of A356 melts were examined. A total of 120 reduced pressure test samples were collected. Pores in these samples were analyzed via digital image processing to determine the number density of pores as well as the statistical distribution of their sizes. Results showed that in all cases, degassing with argon reduced the number of defects regardless of the additions made to the melts. Moreover, all additions were found to degrade melt quality. The lowest number density of pores in all melts was achieved in melts with no additions that were degassed. In both degassed and non-degassed melts, Sr additions degraded the melt quality significantly. The mechanisms of melt quality improvement or degradation with different melt treatments are discussed in the paper.
Proceedings of 3rd Australian Lipid Meeting
Authors: Brown Simon , Rupasinghe Thusitha W. T.
Published: May 2017

More than 100 lipid researchers from across Australia participated in the 3rd Australian Lipid Meeting (ALM3), held on the 21st and 22nd of November 2016 in Melbourne, Australia.[...]