bluuebunny/crossref_metadata_2025 huggingface dataset:
Determinants of Breast Cancer Screening Among Reverend Sisters in Kampala Archdiocese, Uganda: A Cross-Sectional Study
Authors: Basaza Robert K. , Kaddu Judith , Otieno Emmanuel , Mirembe Florence
Published: March 2022

Background: Breast cancer in Uganda is the second commonest cancer in women coming only next to cancer of the cervix. This is the first cross-sectional study to investigate the determinants of self-breast cancer screening among Reverend Sisters in Kampala, the largest Archdiocese of Roman Catholic Church in Uganda. The prevention strategies in this country are still not optimal and the key to prevention is breast screening.Methods: A cross-sectional analytical study was conducted from September, 2018 to June, 2019. A sample of 310 respondents were interviewed using a semi-structured, self-administered questionnaire. Data was analyzed using logistic regression model.Results: A majority (96.4%) of the respondents did not do a mammography, 54.1% never practiced breast self-examination (BSE) and 34.2% performed it regularly during bedtime. The reasons for performing BSE included: curiosity (61.9%), having a lump (19%) and carrying out screening (9.5%). Significant predictors of breast cancer screening were ordinary level of education (11 years of education), hearing about breast cancer, different screening methods, and symptoms of breast cancer, usefulness of screening for women, a need for sisters to screen, self-breast examination and mammography. Age and other levels of education were not significantly associated with breast cancer screening. Conclusion: The Reverend Sisters had a low level of knowledge and a small fraction practiced breast cancer screening. This demands a sustainable interventional strategy of breast health awareness campaign, establishment of appropriate health infrastructure related to precision oncology in Uganda and similar settings.
“Dashing and daring, courageous and caring”: Neomedievalism as a Marker of Anthropomorphism in the Parent Fan Fiction Inspired by Disney’s Adventures of the Gummi Bears
Authors: Mussies Martine
Published: March 2022

As is already visible in its opening credits, the television series Disney’s Adventures of the Gummi Bears (1985–1991) uses neomedievalism to confirm the anthropomorphism of the titular characters. More than 35 years after this series’ first episode aired, this phenomenon is still easily traceable in the parent fan fiction, online stories about the Gummi Bears, written for children by adults. This paper addresses two seemingly overlooked fields: The Gummi Bears series and the fan fiction it inspired. It shows that this anthropomorphic perception adds new perspectives on human relations with the natural environment and on the treatment of animals, and thus contributes to building the awareness of ecological and animal rights in societies, especially when it comes to future generations.
Kopciuszki dla młodzieży. O rewritingach motywu ATU 510A w literaturze young adult
Authors: Bednarek Magdalena
Published: March 2022

Ludowy motyw ATU 510A jest niezmiernie popularny w literaturze dla dzieci. Kopciuszka spotykamy także w kulturze popularnej, w różnych gałęziach dyskursu publicystycznego, w reklamach, na szyldach. Z pewnością jest więc także znaczącą postacią dla dorosłych. Czy jednak opowieść o sierocie, która poślubia królewicza, może być atrakcyjna dla młodych dorosłych? Artykuł ma na celu zaprezentowanie kierunku zmian w wątku 510A, które czynią możliwym jego obecność w prozie young adult (YA). Autorka poddaje analizie powieści trzech pisarek (Kelly Oram, Ashley Poston oraz Marissy Meyer) adresowane do odbiorców w tej grupie wiekowej obecne na polskim rynku książki. Psychologizacja postaci, rozbudowa tła społeczno-kulturowego oraz wątków pobocznych, dążenie do eliminacji kategorii cudowności, obdarzanie protagonistki sprawczością – są elementami wspólnymi tych rewritingów. Tym, co różni badane narracje, jest ocalenie uniwersalności motywu przez Meyer i jego historyczno-kulturowa konkretyzacja w utworach Oram i Poston.
The Impact of Market Transformation of the Economy on the Evolution of the State-Owned Property Relations in Ukraine
Authors:   National Technical University «Kharkiv Polytechnic Institute», Mytrofanova A. S.
Published: March 2022

Today, the role of the State-owned property in economic systems is dictated by its decisive importance as a real basis for the State to perform its socioeconomic functions. The purpose of the publication is to analyze how the socioeconomic features of the period of market reforming the Ukrainian economy in the 1990s have determined the way of evolution of the State-owned property relations from the past to the present. The publication provides an author’s own definition of the category of «the State-owned property» as one of the system-forming elements of the economic system, which represents a set of relations regarding the possession, use and disposal of means and production results that ensure the effective implementation of the social functions on the part of the State. The theoretical and legal basis of the State-owned property functioning in Ukraine is provided. The characteristic features and problems of the transformation period of economic development of Ukraine are analyzed; the causes, contradictions and consequences of the transformation crisis are disclosed; the progress and features of reforming the State-owned property relations in Ukraine under the indicated conditions are considered. The article provides a characterization of the current stage of development of the State-owned property in Ukraine; the current tendencies in the volume and structure of corporate rights of the State by types of economic societies and the size of the State share are presented. The current tendencies of privatization in Ukraine (the contradictory influence of the new legislative framework; violation of the fiscal function of privatization; deployment of small privatization exceeds the shift in large-scale privatization) and the problems of the State-owned property development in the economy of Ukraine in general are also characterized (among them: controversial nature of privatization; low efficiency of the State-owned property management; difficulties of the State-owned enterprises as economic units; ermine of property rights; contradictions in the field of «property-power»). A perspective direction of further research in this area is a more detailed analysis of the socioeconomic efficiency of the State-owned property management
The Infrastructure Provision of Tourism on the Example of Event Tourism in Ukraine
Authors:   O. M. Beketov National University of Urban Economy in Kharkiv, Ryabev A. A. , Shyian D. V. ,   O. M. Beketov National University of Urban Economy in Kharkiv
Published: March 2022

Event tourism occupies one of the leading places among other types of tourism. It provides the possibility to make a stable profit both to its organizers and to the countries where these events take place. It should be noted that any event requires appropriate conditions – tourism infrastructure, in which it will be implemented with the maximum positive result for all participants in the tourism sphere, which generally differs from other types of economic activity by an increased degree of risk due to seasonality, variability of demand from consumers of tourist products, etc. The state of uncertainty in the case of tourism infrastructure in general and on the example of event tourism in particular can be overcome by supplementing the existing types of classification of event tourism with new additional types, namely: «by frequency of conduct» (one-time and repeated); «by the venue» (permanent and transitional); «depending on the season» (dependent and independent). These additional types of classification will allow the authorities (several countries, a separate country, region, locality) that manage the entities of tourism activities – tourism and recreation centers, event organizers, producers of services and goods (including tourist goods), intermediaries represented by tour operators and travel agents to understand the amount of necessary transformations of the existing tourism infrastructure, subject to its existence or works on its creation. This, in turn, will help in the future to hold events that will bring profit and/or increase the image of tourism and recreation centers, will facilitate the development of other types of tourism through the use of already created or transformed tourism infrastructure, which is no less important than natural, historical, cultural and other anthropogenic recreational and tourism resources. As for potential consumers, the proposed additional types of classification of event tourism will increase the attractiveness of events due to their clearer differentiation according to the relevant signs.
A Theoretical Substantiation of the Enterprises’ Participation Models in Achieving Global Sustainable Development Goals
Authors:   National Technical University «Dnipro Polytechnic», Pashkevych M. S. , Li Guannan ,   National Technical University «Dnipro Polytechnic»
Published: March 2022

The article is concerned with the relevant issue both for Ukraine and the world of achieving global sustainable development goals based on the participation of enterprises (businesses) in ecological conservation processes and improving social well-being against the background of economic growth. The article is aimed at presenting the results of a study of the theoretical substantiation of models of the enterprise’s participation in achieving the global goals of sustainable development. Based on the use of general scientific research methods, it was logically substantiated that under the participation of enterprise in achieving the global goals of sustainable development, it is necessary to understand the alienation of assets or the acceptance of obligations to implement projects that correspond to sustainable development in the internal and external environment. On this basis, it is proposed to distinguish between four models of enterprise participation in processes aimed at achieving global sustainable development goals: «Outsider», «Activist», «Contributor», «Active Contributor». These models are based on two important characteristics: the presence or absence of internal transformation processes in favor of sustainable development at the enterprise, as well as the presence or absence of projects for financing transformations in favor of sustainable development in the external environment. The substantiation of the company’s behavior models in terms of the implementation of the global sustainable development goals allowed to propose an interpretation of the sustainable development of the enterprise in terms of its participation in these processes. In the logical course of the study, the types of sustainable development of enterprise are substantiated as follows: «driver», «supporter», «integrator». It is proved that these types should be determined on the basis of the ratio of the enterprise’s participation in sustainable development due to its activity in transformation processes in the internal and external environment. An analysis of the compliance of four models of enterprise participation in the implementation of the global sustainable development goals with three types of sustainable development of the enterprise is accomplished. Further research will concern the effectiveness of a particular model of enterprise participation in sustainable development from the point of view of different stakeholders.
Problems and Ways to Increase the Efficiency of Inventory Management of a Trading Company
Authors:   Prydniprovska State Academy of Civil Engineering and Architecture, Shevchenko-Kulchytska K. I. , Spiridonova K. O. ,   Prydniprovska State Academy of Civil Engineering and Architecture, Kakhovska O. V. ,   Prydniprovska State Academy of Civil Engineering and Architecture
Published: March 2022

The article defines the economic essence of stocks from the point of view of domestic and foreign scholers, as well as in accordance with the legislation of Ukraine. It is specified that the main form of sale of inventory are independent wholesale and retail trade enterprises. The detailed classification of stocks, which is necessary to track the dynamics of consumer demand and planning rational volumes of purchase of products, which is important for ensuring uninterrupted sale, is considered. The main models and systems of inventory management are analyzed, such as the system with the established volume or size of the order, the system with a certain frequency of the order, the model of the optimal size of the Harris – Wilson order. The main tasks of inventory management at the enterprise are determined as follows: minimization of warehouse costs for storage of goods by accelerating the turnover of inventory; ensuring the optimal number of goods that can be sold in the near future and will bring profit. Thus, it was clarified that the main purpose of inventory management is to form and maintain their value at a level that allows for uninterrupted trade in each product at minimal cost. The process of choosing the optimal level of stocks is considered. An ABC- and XYZ-analysis based on commodity stocks of LLC «RUSH» is carried out. Recommendations for the management of different groups of goods are elaborated. It is defined that it is extremely important for any trading network to find the optimal combination between the costs and benefits of the selected level of inventories in order to determine what value of stocks for each product group or even a goods item is sufficient, as well as to choose the correct inventory management model for each category of goods.
The Current Approaches to Substantiation of Criteria for Evaluation and Selection of Suppliers
Authors:   Department of the Business Logistics and Transport Technologies, State University of Infrastructure and Technologies, Petrenko O. I. , Korniiko Y. R. ,   Department of Business Logistics and Transport Technologies, State University of Infrastructure and Technologies, Lushchik K. M. ,   State University of Infrastructure and Technologies
Published: March 2022

The article is aimed at studying the current approaches to substantiating the criteria for evaluating and selecting suppliers. The study of theoretical and practical aspects allowed to distinguish modern methods of selecting suppliers in the field of procurement logistics. It is identified that there are a number of basic and additional methods for evaluating suppliers. Almost every method can be used in combination with others. In addition, modern information technologies make it possible to optimize and rationalize the evaluation process. Despite the fact that today most companies are actively working in search of directions for optimizing the work of procurement logistics, only few of them managed to fully realize the potential of at least one of the areas of procurement optimization. At the same time, after analyzing their experience, it is possible to determine what skills and methods of work are necessary for the comprehensive optimization of procurement. The authors propose an improved algorithm for evaluating suppliers, which provides for the use of existing methods of evaluation of work and the most common criteria for the selection of suppliers, taking into account the integral assessment and distribution of indicators according to additional criteria for reliability groups in order to improve the procurement logistics system of enterprises. The basis of this algorithm was the conduct of an extended assessment on additional criteria, such as: the level of supply organization, the level of loyalty of the supplier, the level of perspectivity, while the integral indicator should provide for the inclusion of coefficients of relative significance of additional evaluations by independent experts and the criteria themselves.
The Fintech Risks Management of the Banking Sector
Authors:   Kyiv National Economic University named after V. Hetman, Lavreniuk V. V.
Published: March 2022

The article is aimed at researching the impact and directions of fintech risk management in the banking sector. The article identifies key tendencies in the development of fintech innovations for the banking sector and explores the potential impact of their implementation on banks. According to the results of the analysis, fintech risks are systematized and the essence of each of them is disclosed. It is defined that an efficient direction for improving the efficiency of fintech risk management is to establish cooperation between banks and fintech companies. The study of foreign and domestic practice allowed to distinguish four main areas of partnership with: 1) fintech companies operating outside the banking sector; 2) fintech companies offering fintech solutions for banks; 3) fintech companies supplying destructive technologies; 4) fintech companies relying on current bank offers. The main channels of fintech risk transmission to the banking sector are identified. It is determined that the consequences of the implementation of fintech risks are manifested through the following traditional banking risks: operational, compliance, strategic, reputational. It is proved that in most cases, the events of fintech risk implementation on different business lines will be classified as consequences of operational risk. It is determined that the management of fintech risks in the banking business should be based on generally accepted approaches to risk management, taking into account the business model of a credit institution. It is determined that minimization of the impact of fintech risks is facilitated by the regulation of cooperation with fintech companies on the implementation of fintech innovations (development of strategies, policies, procedures, methods). The prospect of further research in this direction is the development of models for quantitative assessment of fintech risks. A significant positive impact on the efficiency of risk management of banks will be the development of methodological recommendations for stress testing, taking into account fintech risks. In the future, there is a need to develop appropriate models for the impact of fintech risks on the balance sheet of banks and adequate stress scenarios.
Assessing the Impact of Budget Decentralization and Tax Revenues of the City of Irpin
Authors:   The University of the State Fiscal Service of Ukraine, Bedrinets M. D. , Ugriumova K. O. ,   Banking of the University of the State Fiscal Service of Ukraine, Kolesnik K. O. ,   Banking of the University of the State Fiscal Service of Ukraine
Published: March 2022

The article considers the theoretical foundations and problems of functioning of local self-government bodies in the implementation of budget decentralization in Ukraine. In the process of reforming local authorities, the dependence of local budgets on the State budget is determined. The development of budget decentralization for the period 2015–2021 is considered, namely: the number of amalgamated hromadas, the share of the local budgets’ own revenues, and the structure of the share of revenues of the general fund of local budgets (without transfers). The revenues to the budget of the city of Irpin, their tendencies and efficiency of use are highlighted and analyzed. The forecast of budget revenues in the city of Irpin is developed taking into account all indicators used to assess tax revenues and fees, expected indicators of socioeconomic development and expected tax revenues of taxes and fees, as well as taking into account the proposals of the bodies that control the distribution of tax revenues and fees to local budgets of the region. The role of taxes in the system of local regulation of economic processes provides an impact on society, its structure and dynamics, ensures the stability of budget revenues and self-sufficiency, which provide for the development of an effective strategy for the development of the tax system based on realistic forecasts of socioeconomic development. The methods for improving control over the financing of local authorities are proposed. Local self-government bodies are able to transform the tax base at the local level through tax revenues, which provides opportunities for the full implementation of their functions and powers influencing the financial and economic processes. For the future forecast and improvement of sustainable development, it is necessary to anticipate the threats and risks of financial stability. Thus, their negative manifestation in the future is minimized or ways to minimize losses from their impact are determined
Evolution of the Conception of Sustainable Development: A Managerial Perspective
Authors:   Kyiv National University of Trade and Economics, Piatnytska G. T. , Hryhorenko O. M. ,   Kyiv National University of Trade and Economics
Published: March 2022

The article is aimed at analyzing the evolution of the conception of sustainable development with the definition and substantiation of the likely prospects for its further changes. To achieve the aim, general-scientific and special research methods were used. As a result of the systematization of scientific approaches to the definition of the concept of «sustainable development» and the identification of three stages of the evolution of the conception of sustainable development, a forecast was made regarding the likely next stage of the evolution of the conception of sustainable development. It is substantiated that the management of sustainable development in the strategic perspective can be associated with the coordination and implementation of social, economic, environmental, and technological development goals. It is emphasized that technological changes will contribute to and emphasize the importance of scientific-technological progress as such and in the context of ensuring social standards and guarantees, improving the quality and safety of life of absolutely all categories of the population, creating appropriate conditions for environmental protection and economic growth. It is assumed that the technological goals of sustainable development will also concern the security of technological changes for the development of mankind related to global digitalization and robotization of the economy and everyday life. The results of the research can be used in further scientific research on the problems of determining strategic benchmarks and sustainable development tasks.
Recruitment as a Technology of Effective Attraction and Onboarding of Staff
Authors:   Kyiv National University of Trade and Economics, Zhukovska V. M. , Mykolaichuk I. P. ,   Kyiv National University of Trade and Economics, Marnyalo A. M. ,   Kyiv National University of Trade and Economics, Shoma M. S. ,   Kyiv National University of Trade and Economics
Published: March 2022

The article analyzes the essence and trends in the development of recruitment technology as a technology for attraction and onboarding of staff. The authors’ interpretation of the content of recruitment as a process of attracting, picking up, and selecting staff along with the use of technologies of its involvement in the organization, thanks to the facilitation of a number of positive factors of the working environment and socio-psychological climate, is presented. The article is aimed at theoretical generalizing the methodological approaches to the application of analytical instruments for an effective recruitment and developing proposals for its use in the course of involvement and onboarding of staff at the enterprise. The relationship between recruiting and staff attracting processes is studied. The main differences between the concepts of «picking up», «selecting» and «attracting» staff are characterized. The characterizations of the main trends in the development of modern recruitment technology are provided. Novelties in the strategy of selection, valuation and onboarding of applicants by means of video-chats, HR-bots etc. are analyzed. Prospects for the use of digital recruiting in the practice of staff management are substantiated. It is determined that the prognosis analytic instruments as part of recruitment of international companies are furthermore systematically used in the adaptation training of both soft and hard skills applicants in the context of achieving the company’s business goals. Indicators and criteria for valuating the efficiency and effectiveness of staff recruitment are proposed. The need for further research of recruitment technology based on the experience of foreign countries is substantiated
Status of Sex Education at Elementary Schools in Bangladesh: A Comparative Study among Few Schools in Dhaka
Authors: Hossain BM Sajjad , Rushni Korishi  , Kamruzzaman Molla
Published: March 2022

Education is considered as a backbone of a nation. For sustainable development, education is the first prerequisite. It plays vital role for socioeconomic development of a society. For the last few decades, Government of Bangladesh has tried to ensure maximum number of participant under the light of education. A lot of projects have been initiated for education development of the nation to spade it to reach the mass and root level. The number of participant has been increased a lot, but the problem is that the education system in Bangladesh has been run under different separate streams and mostly is traditional. Nonetheless, the sex education is absent in most of the curriculum, in fact, at all the main streams elementary school levels in Bangladesh but it is considered as a very much essential part of the schooling process in developed nations. This paper had based on primary data collected from several schools under different streams and attempted to have a comparative study among them. Without including sex education at a large scale in the main stream education process of this country, it is impossible to reduce sexual harassment, children abuse, unwanted pregnancy and related difficulties.
AMALGAMATION OF INDIRECT GAMIFICATION INTO DEVELOPMENT AND OPERATIONS (DEVOPS) COURSE TEACHING
Authors: Devare Manoj
Published: March 2022

The work investigates the effect of indirect Gamification in Development and Operations (DevOps) Course teaching. The software development team consisting of multiple contributors coordinates in the collaborative work environment to achieve specific predefined goals in a regulated and controlled fashion. In DevOps Course, the Installation and configuration of the various software tools are useful in the context of application development. To teach DevOps Tools precisely to achieve the learning outcome is a skilled task for a trainer. From the perspective of the learner, the learning environment has to be encouraging and exciting. Pedagogical techniques and ICT tools play an essential role during the knowledge transfer process. The motivation and reward to the Student are essential in achieving the learning outcomes of the Course. The author used the third-party Competition as an indirect Gamification technique to achieve the learning outcomes of the Course. The author encouraged the students to participate in the Hacktoberfest Competition to use the practical skills learned in the Course. The Under Graduate (UG) and Post Graduate (PG) Students have gone through the regular sessions of DevOps. For the participation purpose, both groups of students communicated on one platform. The students who succeeded faster during the GitHub Pull Request (PR) submission shared their experiences with other participants. The PG students participated 68.75% higher than UG students. Minimum of four PR submissions on GitHub and acceptance by the repository maintainer are the task completion criteria. The active participation of the small number of UG students became a motivational factor for the PG students. The Gaussian distribution on the marks obtained by the experimental group shows the absence of outliers. The research shows that the effectiveness of indirect Gamification depends on the age group, level, course content, and learning environment. The participation of a faculty member in the Competition during the learning activity boosts the desire of the Student to complete the task. The experimental group of 15 Students has outperformed in terms of the marks obtained compared to the control group of 52 students.
Kil Esaslı Bütünüyle-Katı-Hal Kompozit Kurşun (II)-Seçici Potansiyometrik Elektrot
Authors: DOĞAN Bilge , ÇAĞLAR Bülent , TOPCU Cihan , ÇOLDUR Fatih , ÖZDEMİR Agah , KELEŞ GÜNER Eda , ÇUBUK Osman , ÖZDOKUR Volkan
Published: March 2022

Bentonit kili XRD, FTIR ve SEM-EDX teknikleriyle karakterize edildi. Karakterize edilen kil bütünüyle katı hal kompozit potansiyometrik elektrot yapımında iyonofor madde olarak kullanılmış ve kilin potansiyometrik uygulaması gerçekleştirilmiştir. Elektrodun Pb2+ iyonuna karşı, diğer yaygın inorganik katyonlarla karşılaştırıldığında oldukça duyarlı ve seçici potansiyometrik bir cevap sergilediği gözlemlenmiştir. Membran optimizasyon çalışmaları neticesinde en iyi potansiyometrik performans özellikleri sergileyen bileşimin kütlece % 65.0 grafit, % 5.0 çok duvarlı karbon nanotüp, %20.0 iyonofor (bentonit) ve %10.0 parafin yağı olduğu belirlenmiştir. Pb2+ seçici kompozit elektrodun 1.0×10-5 ˗ 1.0×10-1 M konsantrasyon aralığında doğrusal cevap sergilediği, doğrusal çalışma aralığında standart Pb2+ çözeltilerine karşı her 10 katlık konsantrasyon değişiminde ortalama 31 mV potansiyel fark sergilediği gözlenmiştir. Elektrodun tayin sınırı 9.0×10-6 M olarak hesaplanmıştır. Elektrodun cevap zamanının oldukça kısa olduğu (~5 s) potansiyometrik cevabın ve tekrarlanabilirliğinin de oldukça yüksek olduğu ortaya konmuştur.
INVESTIGATING TOURISTS’ INTENTION TO REVISIT A BATIK- BASED TOURISM DESTINATION: HOW DOES THE ROLE OF DESTINATION IMAGE?
Authors: Candra Elena Puspita , Suhud Usep , Febrilia Ika
Published: March 2022

This study aims to examine the factors that influence revisit intention (z) such as destination image (x1) and perceived value (x2) as independent variable, tourist satisfaction (y1) and memorable tourism experience (y2) as intervening variable. Data collection is done with survey methods, and the instruments used were questionnaires. The number of samples used in this study were 259 respondents in the form of tourists, both the archipelago and foreign tourists who traveled and shopped in Batik Trusmi Area, Cirebon. Data analysis uses SPSS version 22 and AMOS version 22 techniques to process the research data. Then, the study revealed that destination image and perceived value positively and significantly influence satisfaction. Destination image and perceived value affect the memorable tourism, satisfaction and memorable tourism have a positive and significant effect on revisit intention.
TUNDA ISLAND AS A TOURIST ATTRACTION IN TIRTAYASA DISTRICT, SERANG REGENCY
Authors: Umam Chotibul , Novianti Evi
Published: March 2022

The lack of research related to the potential for tourist attraction of Tunda Island from natural, artificial, cultural, and various other aspects based on existing conditions, is the urgency of this research. Tourist visits that are still fluctuating require special attention from the Serang Regency Government to optimize development. Therefore, this study's purpose is to identify the existing conditions and tourism potential of Tunda Island. Thus it can become a guideline for decision-making related to the tourism development in Tunda Island in the future. This research used qualitative research methods with a case study design. By purposive sampling, informants who are the community and tourism managers of Tunda Island were selected for in-depth interviews. The proportion of the results of this study was also more inclined to the field observations to achieve the research objectives. Secondary data came from literature studies related to previous research and also document studies from data to Tunda Island. The results showed that the potential of Tunda Island as a tourist attraction has the opportunity or the potential for natural or marine tourism. However, the potential cultural tourism attractions, both tangible and intangible, also need to be packaged and raised as a tourist attraction based on local potential. Also found in the potential for an artificial tourist attraction that can support tourism on Tunda Island. In the end, the results of this study expected to become input for the Serang Regency Government and other stakeholders to develop tourism activities that are relevant and able to integrate cultural, natural, and artificial tourism attractions.
Surface Modification Techniques to Produce Micro/Nano-scale Topographies on Ti-Based Implant Surfaces for Improved Osseointegration
Authors: Hou Chuang , An Jing , Zhao Duoyi , Ma Xiao , Zhang Weilin , Zhao Wei , Wu Meng , Zhang Zhiyu , Yuan Fusheng
Published: March 2022

Titanium and titanium alloys are used as artificial bone substitutes due to the good mechanical properties and biocompatibility, and are widely applied in the treatment of bone defects in clinic. However, Pure titanium has stress shielding effect on bone, and the effect of titanium-based materials on promoting bone healing is not significant. To solve this problem, several studies have proposed that the surface of titanium-based implants can be modified to generate micro or nano structures and improve mechanical properties, which will have positive effects on bone healing. This article reviews the application and characteristics of several titanium processing methods, and explores the effects of different technologies on the surface characteristics, mechanical properties, cell behavior and osseointegration. The future research prospects in this field and the characteristics of ideal titanium-based implants are proposed.
Targeted Codelivery of Prodigiosin and Simvastatin Using Smart BioMOF: Functionalization by Recombinant Anti-VEGFR1 scFv
Authors: Mirzaeinia Somayyeh , Zeinali Sedighe , Budisa Nediljko , Karbalaei-Heidari Hamid Reza
Published: March 2022

Biological metal-organic frameworks (BioMOFs) are hybrid compounds in which metal nodes are linked to biocompatible organic ligands and have potential for medical application. Herein, we developed a novel BioMOF modified with an anti-VEGFR1 scFv antibody (D16F7 scFv). Our BioMOF is co-loaded with a combination of an anticancer compound and a lipid-lowering drug to simultaneously suppress the proliferation, growth rate and metastases of cancer cells in cell culture model system. In particular, Prodigiosin (PG) and Simvastatin (SIM) were co-loaded into the newly synthesized Ca-Gly BioMOF nanoparticles coated with maltose and functionalized with a recombinant maltose binding protein-scFv fragment of anti-VEGFR1 (Ca-Gly-Maltose-D16F7). The nanoformulation, termed PG + SIM-NP-D16F7, has been shown to have strong active targeting behavior towards VEGFR1-overexpresing cancer cells. Moreover, the co-delivery of PG and SIM not only effectively inhibits the proliferation of cancer cells, but also prevents their invasion and metastasis. The PG + SIM-NP-D16F7 nanocarrier exhibited stronger cytotoxic and anti-metastatic effects compared to mono-treatment of free drugs and drug-loaded nanoparticles. Smart co-delivery of PG and SIM on BioMOF nanoparticles had synergistic effects on growth inhibition and prevented cancer cell metastasis. The present nanoplatform can be introduced as a promising tool for chemotherapy compared with mono-treatment and/or non-targeted formulations.
Ruderal Resilience: Applying a Ruderal Lens to Advance Multispecies Urbanism and Social-Ecological Systems Theory
Authors: Kennedy Christopher
Published: March 2022

As global urbanization accelerates, cities have become increasingly complex and hybridized, and host to novel urban landscape forms such as informal greenspaces or novel ecosystems that support ruderal and spontaneous vegetation. Researchers have documented the ecosystem services or benefits these systems provide, as well as the tradeoffs or disservices associated with biotic globalization. Despite evidence of their co-benefits, fragmented knowledge and biased views of these novel ecological forms contributes to an underestimation of their social-ecological role and potential for serving as a model for resilient and nature-based urban design and planning. The social-ecological systems discourse has improved understanding of these emerging conditions, yet may benefit from an attunement to a multispecies perspective, an ecosystem-based approach to urban planning and governance that recognizes the interdependencies of humans and other organisms. This article explores the potential social-ecological role of ruderal landscapes in facilitating this transition, referred to as ruderal resilience, as well as recent research in SES and resilience theory that may help advance concepts such as multispecies urbanism and planning. The aim is to consider the potential for spontaneous ecological self-organization to serve as a device for reinvigorating relationships with urban ecological commons and advancing social-ecological systems theory.
Performance-Based Design of Tall Timber Buildings Under Earthquake and Wind Multi-Hazard Loads: Past, Present, and Future
Authors: Tesfamariam S.
Published: March 2022

The rapid growth of the urban population and associated environmental concerns are challenging city planners and developers to consider sustainable and cost-efficient building systems. Timber-based buildings, such as sustainable systems, are increasingly used. The timber buildings, however, being lighter and flexible, can be vulnerable to earthquakes and wind loads. This paper gives a state-of-the-art review on performance-based design (PBD) considerations and future direction for timber and timber-based hybrid buildings. The PBD review covered both earthquake and wind loads and multi-hazard design considerations. The review also provided 1) current practice and future direction in consideration of hazard, response, and loss assessment within the multi-hazard PBD, 2) damping and energy dissipation devices, 3) optimization under uncertainty, and 4) future of surrogate and multi-fidelity modeling in PBD.
The Role of Iron in Staphylococcus aureus Infection and Human Disease: A Metal Tug of War at the Host—Microbe Interface
Authors: van Dijk Madeleine C. , de Kruijff Robin M. , Hagedoorn Peter-Leon
Published: March 2022

Iron deficiency anemia can be treated with oral or intravenous Fe supplementation. Such supplementation has considerable effects on the human microbiome, and on opportunistic pathogenic micro-organisms. Molecular understanding of the control and regulation of Fe availability at the host-microbe interface is crucial to interpreting the side effects of Fe supplementation. Here, we provide a concise overview of the regulation of Fe by the opportunistic pathogen Staphylococcus aureus. Ferric uptake regulator (Fur) plays a central role in controlling Fe uptake, utilization and storage in order to maintain a required value. The micro-organism has a strong preference for heme iron as an Fe source, which is enabled by the Iron-regulated surface determinant (Isd) system. The strategies it employs to overcome Fe restriction imposed by the host include: hijacking host proteins, replacing metal cofactors, and replacing functions by non-metal dependent enzymes. We propose that integrated omics approaches, which include metalloproteomics, are necessary to provide a comprehensive understanding of the metal tug of war at the host-microbe interface down to the molecular level.
The Expression and Function of Tubulin Isotypes in Caenorhabditis elegans
Authors: Lu Yu-Ming , Zheng Chaogu
Published: March 2022

Microtubules, made from the polymerization of the highly conserved α/β-tubulin heterodimers, serve as important components of the cytoskeleton in all eukaryotic cells. The existence of multiple tubulin isotypes in metazoan genomes and a dazzling variety of tubulin posttranslational modifications (PTMs) prompted the “tubulin code” hypothesis, which proposed that microtubule structure and functions are determined by the tubulin composition and PTMs. Evidence for the tubulin code has emerged from studies in several organisms with the characterization of specific tubulins for their expression and functions. The studies of tubulin PTMs are accelerated by the discovery of the enzymes that add or remove the PTMs. In tubulin research, the use of simple organisms, such as Caenorhabditis elegans, has been instrumental for understanding the expression and functional specialization of tubulin isotypes and the effects of their PTMs. In this review, we summarize the current understanding of the expression patterns and cellular functions of the nine α-tubulin and six β-tubulin isotypes. Expression studies are greatly facilitated by the CRISPR/Cas9-mediated endogenous GFP knock-in reporters and the organism-wide single cell transcriptomic studies. Meanwhile, functional studies benefit from the ease of genetic manipulation and precise gene replacement in C. elegans. These studies identified both ubiquitously expressed tubulin isotypes and tissue-specific isotypes. The isotypes showed functional redundancy, as well as functional specificity, which is likely caused by the subtle differences in their amino acid sequences. Many of these differences concentrate at the C-terminal tails that are subjected to several PTMs. Indeed, tubulin PTM, such as polyglutamylation, is shown to modulate microtubule organization and properties in both ciliated and non-ciliated neurons. Overall, studies from C. elegans support the distinct expression and function patterns of tubulin isotypes and the importance of their PTMs and offer the promise of cracking the tubulin code at the whole-genome and the whole-organism level.
Combining EGFR-TKI With SAHA Overcomes EGFR-TKI-Acquired Resistance by Reducing the Protective Autophagy in Non-Small Cell Lung Cancer
Authors: Cao Peijun , Li Yongwen , Shi Ruifeng , Yuan Yin , Gong Hao , Zhu Guangsheng , Zhang Zihe , Chen Chen , Zhang Hongbing , Liu Minghui , Pan Zhenhua , Liu Hongyu , Chen Jun
Published: March 2022

Nowadays, lung cancer has the highest mortality worldwide. The emergence of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) has greatly improved the survival of patients with non-small cell lung cancer (NSCLC) having EGFR-TKI-sensitive mutations. Unfortunately, acquired resistance happens for most patients. In the present research, we found that EGFR-TKIs (such as gefitinib and osimertinib) can induce autophagy in NSCLC cell lines. Compared with parental sensitive cells, drug-resistant cells have higher autophagy activity. The use of an autophagy inhibitor could enhance the toxicity of gefitinib and osimertinib, which indicates that the enhancement of protective autophagy might be one of the mechanisms of EGFR-TKI resistance in NSCLC. In addition, increased autophagy activity is associated with decreased enhancer of zeste homolog 2 (EZH2) expression. Knockdown of EZH2 or EZH2 inhibitor treatment could lead to increased autophagy in NSCLC cells, indicating that EZH2 is a negative regulator of autophagy. We revealed that the increase in autophagy caused by the reduction of EZH2 was reversed in vitro and in vivo when combining gefitinib or osimertinib with suberoylanilide hydroxamic acid (SAHA), a broad-spectrum histone deacetylase inhibitor (HDACi). In conclusion, our results indicated that the combination of EGFR-TKIs and SAHA may be a new strategy to overcome EGFR-TKIs acquired resistance.
The Dual Descriptor Reveals the Janus–Faced Behaviour of Diiodine
Authors: Martínez-Araya Jorge I.
Published: March 2022

The Janus–faced ligand behavior of diiodine (I2) was evidenced after applying the dual descriptor (DD or second-order Fukui function), thus providing additional support to the work performed by Rogachev and Hoffmann in 2013. Along with its capacity to reveal sites susceptible to undergo attacks simultaneously of nucleophilic and electrophilic types, another advantage of DD lies in being an orbital-free descriptor. That means it is based only upon total electron densities when written in its most accurate operational formula. This quality is not exclusive of DD because when Fukui functions are written in terms of electron densities instead of densities of frontier molecular orbitals, they become orbital-free descriptors too. Furthermore, the present work is an application of the generalized operational formula of the dual descriptor published in 2016 that takes into account any possible degeneracy in frontier molecular orbitals. As a proof about capabilities of DD, the possible sites for a favorable interaction between I2 with two organometallic compounds [Rh2(O2CCF3)4] and [(C8H11N2)Pt (CH3)] were correctly revealed by overlapping the biggest lobe for receiving nucleophilic attacks of one molecule with the biggest lobe for receiving electrophilic attacks of the other molecule, so allowing to predict the same coordination modes as experimentally known: linear “end–on” for the [(C8H11N2)Pt (CH3)]…I2, and bent “end–on” for the [Rh2(O2CCF3)4]…I2 interactions.
Macrophage Mediated Immunomodulation During Cryptococcus Pulmonary Infection
Authors: Wang Yan , Pawar Siddhi , Dutta Orchi , Wang Keyi , Rivera Amariliz , Xue Chaoyang
Published: March 2022

Macrophages are key cellular components of innate immunity, acting as the first line of defense against pathogens to modulate homeostatic and inflammatory responses. They help clear pathogens and shape the T-cell response through the production of cytokines and chemokines. The facultative intracellular fungal pathogenCryptococcus neoformanshas developed a unique ability to interact with and manipulate host macrophages. These interactions dictate howCryptococcusinfection can remain latent or how dissemination within the host is achieved. In addition, differences in the activities of macrophages have been correlated with differential susceptibilities of hosts toCryptococcusinfection, highlighting the importance of macrophages in determining disease outcomes. There is now abundant information on the interaction betweenCryptococcusand macrophages. In this review we discuss recent advances regarding macrophage origin, polarization, activation, and effector functions duringCryptococcusinfection. The importance of these strategies in pathogenesis and the potential of immunotherapy for cryptococcosis treatment is also discussed.