bluuebunny/crossref_metadata_2025 huggingface dataset:
Perjuangan Tokoh Utama dalam Membela Agama dalam Novel Rembulan Di Langit Konstantinopel di dalam Membangun Karakter Bangsa
Authors: Tiffany Jihan Zelvia
Published: July 2020

Novel mampu menghibur dan memberikan manfaat bagi pembacanya. Di Indonesia sendiri novel banyak menceritakan romantis,keagamaan, social, ekonomi dll. Salah satu satrwan yang membicarakan keagamaan adalah El Salman Ayashi Rz. Tujuan peneliti ini adalah untuk mendeskripsikan nilai-nilai religiousitas yang terdapat dalam novel karya El Salman Ayashi Rz. Sumber data yang digunakan dalam penelitin ini yaitu  novel karya El Salman Ayashi Rz yang berjudul  Rembulan di Langit Konstatinopel. Penelitian ini dikaji menggunakan teori K. Bertens tentang moral dan agama yan mampu menjawab nilai-nilai religiousitas pada novel karya El Salman Ayashi Rz. Hasil penenlitian menunjukkan bahwa pengarang dalam novel menitik beratkan pada hubungan manusia dengan Tuhan yaitu (1) kepribadian tokoh, (2) nilai moral yangterdapat didalam jiwa tokoh, (3)kebahagian , (4) keegoisan manusia yang mementingkan diri sendiri, (5)kegigihan dalam berjihad. Nilai-nilai kereligiousan di dalam novel El Salman Ayashi Rz lebih ditonjolkan pada sikap tokoh utama yang senantiasa beriman kepada Tuhan.                   Kata kunci: Novel, Moral, Relegiusitas
NILAI-NILAI EDUKATIF PANTUN DALAM TUNJUK AJAR MELAYU KARYA TENAS EFFENDY (KAJIAN SOSIOLOGI SASTRA)
Authors: Raudati Hasni , Adisaputera Abdurrahman
Published: July 2020

Penelitian ini bertujuan untuk menjelaskan nilai-nilai edukatif yang terdapat pada pantun dalam Tunjuk Ajar Melayukarya Tenas Effendy dan menentukan nilai edukatif yang paling dominan.Nilai-nilai edukatif yang dimaksud adalah nilai edukatif religius, nilai edukatif moral, nilai edukatif sosial, dan nilai edukatif budaya. Adapun metode penelitian yang digunakan adalah kualitatif deksriptif.Hasil perolehan data ditemukan bahwa pantun dalam Tunjuk Ajar Melayu karya Tenas Effendy termasuk jenis pantun nasehat. Di dalam pantun-pantun tersebut terdapatsatu pantun yang mengandung nilai edukatif religius, 19 pantun mengandung nilai edukatif moral, 3 pantun mengandung nilai edukatif sosial, dan 4 pantun mengandung nilai edukatif budaya. Dari data yang diperoleh diketahui bahwa pantun-pantun dalam Tunjuk Ajar Melayu karya Tenas Effendy lebih mengutamakan pendidikan moral tentang bagaimana seharusnya bersikap dan bertingkah laku sehari-hari baik dalam kehidupan pribadi ataupun bermasyarakat. Oleh karena itu, maka dapat diketahui bahwa nilai edukatif yang paling dominan adalah nilai edukatif moral. Kata kunci: Nilai Edukatif, Pantun, Tunjuk Ajar Melayu,SosiologiSastra
Enseñanza de la música contemporánea a través de nuevas tecnologías
Authors: Vela González Marta
Published: July 2020

La recepción de la música contemporánea continúa siendo, en la actualidad, desde hace varias décadas, un tema espinoso, a nivel mundial, dado el desencuentro de este tipo de música con el público. Se puede apreciar una situación parecida a nivel educativo, en que la música de los siglos XX y XXI, generalmente, se rehúye a nivel docente y discente. El presente estudio pretende transmitir una experiencia didáctica en estudiantes de nivel superior, en que el proceso de enseñanza-aprendizaje de la música contemporánea se ha tratado con técnicas innovadoras, desde un modelo educativo a distancia, 100% on line. Con una muestra de estudiantes sin experiencia previa en la materia, matriculados en la asignatura optativa de Análisis de la música de los siglos XX y XXI, se ha tratado de elucidar el grado de interés del alumnado, así como el grado de conocimiento obtenido en función de los resultados, en que han incidido cuatro factores de aprendizaje muy concretos. El uso de recursos digitales, a través del campus virtual, así como la práctica de análisis musical gráfico-sonoro, se ha traducido en unos rendimientos finales exitosos.
Study of the Effect of Al2o3&B4c Particles Reinforcement on Some Physical and Mechanical Properties for Aluminum Alloy 6063 by Powder Metallurgy Technique
Authors: Fadhil Abduljabbar Salah
Published: July 2020

Powder metallurgy technique utilized in samples preparing. Samples were compacted by using cold uniaxial pressing then followed by sintering process at 600 oC under inert gas. Results showed improving in (Brinell Hardness, wear resistance & compression strength) and increasing in (density, porosity & water absorption). Brinell Hardness increasing (106. – 114.7), compression strength increasing (35.1 – 40.8) N/mm2 and decrease wear rate (6.6*exp(-8) – 4.22*exp(-8)) g/cm at time  30 min. with (0 – 20)% Al2O3&B4C. While increase apparent density (2.76 – 2.83) g/cm3, Bulk Density increase (2.71-2.82) g/cm3 apparent porosity decrease (1.88 – 0.193) % and water absorption decrease (0.699 – 0.068) % at (0 – 20) % Al2O3&B4C.
RESEPSI PERNIKAHAN (Antara Sakralitas Agama, Hukum, dan Tuntutan Adat)
Authors: Muttaqin Muhammad Ngizzul
Published: July 2020

Celebrating a wedding reception is a necessity and happiness for the bride and groom and their families. In addition to being governed by religion and the state law, wedding receptions are also carried out on the basis of the customs and habits of the people. But in today’s society’s understanding of wedding receptions as a necessity and a requirement that must be carried out based on the luxury and model of events that are mostly carried out by the environment. Until in the end many forget the substance of marriage and favor tradition. As a literature-based study and literature review, this paper will highlight the implementation of a wedding reception from the viewpoint of religion, law and customary demands. The results of this paper are expected to contribute thoughts and understanding of the substance of the wedding reception.
THE NEW THEOLOGY: CONSTRUCTING CRITICAL ISLAMIC THEOLOGY BASED ON HEGEL’S DIALECTIC THEORY
Authors: Thahir Lukman
Published: July 2020

Diskursus teologi Islam saat ini, seperti halnya teologi Kristen di masa modern Barat, mengalami tantangan yang sangat berat, terutama bagaimana aliran pemikiran ini, baik secara rasional, empirik, maupun metodologis, dapat diterima dan sejalan dengan tuntutan dan perkembangan dinamika kemanusiaan kontemporer. Hampir sekitar 10 abad lamanya, isu-isu teologi Islam masih “bermain” di wilayah perdebatan metafisik an sich, di sana, belum menyentuh isu-isu fisik-humanistik-, yang bersifat historis-empiris, di sini. Akibatnya, teologi Islam tidak hanya dianggap meaningless, tetapi juga tidak berdaya, terisolasi dan termarginalisasi dihadapan kekuatan-kekuatan saintisme kontemporer. Artikel ini, ingin membaca ulang teologi Islam dalam konteks   tuntutan dan semangat era kontemporer, dengan berbasis pada teori dialektika Hegel. Tujuannya adalah membangun model teologi alternative yang sejalan dengan semangat tuntutan masa kini. Untuk merumuskan model baru teologi Islam [the new theology] seperti ini, masalah yang diangkat: 1). Bagaimana asal usul diskursus teologi Islam?.2). Mengapa dialektika Hegel yang dijadikan framework atau tool of analysis untuk pembacaan teologi Islam masa kini; dan 3). Bagaimana pembacaan teologi Islam berbasis teori dealektika Hegel?. Hasil penelitian ini dapat dirumuskan sebagai berikut: Pertama, asal-usul teologi Islam, meski ada pengaruh eksternal dari teologi Yahudi, Kristen dan ilmu-ilmu Yunani, namun, faktor internal, dalam hal ini, al-qur’an itu sendiri menjadi sumber yang paling otoritatif munculnya diskusi mengenai teologi dalam Islam.  Kedua, teori dialektika Hegel merupakan sublimasi dari teori argumen filosofis Plato untuk mencairkan dua kutub pemikiran yang berlawanan atau kontradiktif, Socrates dan lawan bicaranya di masa Plato, empirisme dan rasionalisme di masa modern bagi Hegel, dan Mu’tazilah dan Asy’ariyah dalam teologi Islam. Ketiga, pembacaan kontemporer teologi Islam melahirkan model teologi alternative yang dalam tulisan ini disebut Teologi Kritis Islam atau The New Theology.
IMPLEMENTASI FUNGSI PENGAWASAN DEWAN PERWAKILAN RAKYAT DALAM UPAYA MEMPERKUAT SISTEM PRESIDENSIAL DI INDONESIA
Authors: Antari Putu Eva Ditayani
Published: July 2020

DPR memiliki fungsi pengawasan kepada kinerja Presiden disertai dengan hak mengusulkan pemberhentian Presiden kepada MPR, sebagai pelaksanaan fungsi pengawasan. Namun dalam sistem presidensial, hal ini bertentangan dengan syarat fixed term executive. Selain itu politisasi DPR dalam penggunaan hak tersebut menimbulkan anggapan bahwa fungsi pengawasan akan melemahkan sistem presidensial. Hal ini selanjutnya diteliti dan disajikan dalam penulisan analitik deskriptif, menggunakan metode penelitian hukum normatif. Berdasarkan analisis, fungsi pengawasan DPR dalam sistem presidensial tidak melemahkan sistem presidensial. Pengawasan merupakan perimbangan dan pengawasan terhadap kekuasaan Presiden. DPR sebagai lembaga pengawas harus taat pada asas transparansi, akuntabeL, independen dan imparsial. Selain itu adanya MK sebagai penentu keabsahan usul pemberhentian Presiden yang juga dapat mencegah politisasi dalam pemberhentian Presiden. Dengan demikian maka tercipta fungsi pengawasan DPR yang mampu mendukung jalannya sistem presidensial serta membentuk kekuasaan berimbang antar 3 (tiga) bidang kekuasaan negara menurut pandangan Montesquieu.
The impact of individualized care after artificial knee replacement surgery for patients with valgus deformity of the knee†
Authors: Pu Ya-Lou , Li Wei-Tong , Zhi Xiao-Xu , Meng Ai-Feng , Tang Lin , Lu Li-Jing , Wang Peng-Cheng , Xu Zi-Qing , Yao Ye-Nan , Shi Yi-An
Published: July 2020

Objective

To evaluate the perioperative nursing of total knee arthroplasty for patients with valgus deformity of the knee.

Methods

Seventy-six patients who underwent surgical treatment were enrolled in the study from March 2014 to March 2018. The patients in the control group were treated with routine nursing. The experimental group was treated not only with routine nursing but also with health education, psychological care, family social support, and other nursing intervention. Hospital for special surgery and Pittsburgh sleep quality index were used to evaluate the effect of nursing intervention on patients after operation.

Results

All the index scores of the experimental group were lower than those of the control group (P < 0.05), indicating that the function of the diseased limb and the patient's sleep status improved significantly after the intervention.

Conclusions

Individualized nursing can improve the recovery of limb function and improve the patients’ quality of life. It is very effective for nurses to implement individualized nursing measures for patients after surgery.
Cultural competence of nurses in Pudong New Area, Shanghai: a mixed-method study
Authors: Ma Li-Li , Jiang Hui , Peng You-Qing
Published: July 2020

Objective

Cultural competence has gradually attracted attention from many countries, including China. This study was undertaken to determine the cultural competence of registered nurses in Shanghai, China, and to identify the cultural competence among registered nurses in Pudong New Area, Shanghai.

Methods

Qualitative interviews were conducted in combination with a quantitative survey. Fifteen clinical nurses were interviewed, and 1088 clinical nurses were recruited for the survey with cultural competence scale for registered nurses, based on the results of the qualitative and quantitative studies.

Results

The overall level of cultural competence among registered nurses in Shanghai's Pudong New Area was moderate. Among the seven dimensions, cultural encounter had the highest score, followed by cultural practice, cultural awareness, cultural desire, cultural skill, cultural experience, and cultural knowledge. Age, level of hospital care, mastery of secondary level, and studying overseas were the influencing factors.

Conclusions

Hospitals and universities should be aware of the importance of studying cultural competence. Cultural competence-related courses should be increased, and various forms of training should be undertaken to enhance the interest of nurses.
Tree-ring reconstruction of June-July mean temperatures in the northern Daxing’an Mountains, China
Authors: Jiang Yangao , Wang Yu , Zhang Junhui , Han Shijie , Coombs Cassius E.O. , Escobedo Maricely , Wang Junwei , Wang Xiaoguang , Hao Lin , Li Guode , Tong Yijiang , Gu Yue , Dong Shengzhong , He Haisheng , Yang Jingyu
Published: July 2020

In this study, the mean temperature of June to July was reconstructed for the period of 1880 to 2014 by using the Larix gmelinii tree-ring width data for the Mangui region in the northern Daxing’an Mountains, China. The reconstruction accounts for 43.6% of the variance in the temperature observed from AD 1959–2014. During the last 134 years, there were 17 warm years and 17 cold years, which accounted for 12.7% of the total reconstruction years, respectively. Cold episodes occurred throughout 1887–1898 (average value is 14.2°C), while warm episodes occurred during 1994–2014 (15.9°C). Based on this regional study, the warmer events coincided with dry periods and the colder events were consistent with wet conditions. The spatial correlation analyses between the reconstructed series and gridded temperature data revealed that the regional climatic variations were well captured by this study and the reconstruction represented a regional temperature signal for the northern Daxing’an Mountains. In addition, Multi-taper method spectral analysis revealed the existence of significant periodicities in our reconstruction. Significant spectral peaks were found at 29.7, 10.9, 2.5, and 2.2 years. The significant spatial correlations between our temperature reconstruction and the El Niño–Southern Oscillation (ENSO), Pacific Decadal Oscillation (PDO) and Solar activity suggested that the temperature in the Daxing’an Mountains area indicated both local-regional climate signals and global-scale climate changes.
THE SUNDANESE ECO-RELIGION KAMPONG OF KASEPUHAN CIPTAGELAR INDIGENOUS LOCAL COMMUNITY: CASE STUDY KAMPONG CENGKUK, SUKABUMI REGENCY
Authors: Sulistyo Ary
Published: July 2020

Abstract. This research focused on eco-religion of indigenous Sundanese local community of Kasepuhan Ciptagelar at Southern Halimun Mountain on how to manage sustainable environment. The Kampong Cengkuk is one of several kampongs that still follow the tradition of indigenous local community of Kasepuhan Ciptagelar for hundred years. This descriptive qualitative research aims to reveal the internal and external factors led to deforestation of natural forests with average around 6-8% per year. The research shows that the kampong is still practicing eco-religion tradition by protecting forestland (leuweung tutupan) only for their subsistence. The hypothesis is that the social-culture changes had been occurred in the community not only to restrict outer island agriculture in the forest, but also, in wet rice cultivation activities, to manage sustainable environment. The reduction in process and ceremonial activities also happened, which was originally eight ceremonies of outer island agriculture rituals into five ceremonies of wet rice cultivation. The more profane activities were developing economic crops in home garden.

Keywords: Ecoreligion, Kampong, Environment, Forest, Tradition

 

Abstrak. Penelitian ini membahas tentang eko-religi masyarakat lokal Sunda Kampung Ciptagelar di Pegunungan Halimun Selatan bagaimana dalam pengelolaan lingkungan keberlanjutan saat ini. Kampung Cengkuk adalah salah satu dari kampung-kampung pengikut tradisi Kasepuhan Ciptagelar selama ratusan tahun. Penelitian dengan menggunakan pendekatan deskriptif-kualitatif ini yang bertujuan untuk mengetahui faktor dari dalam dan luar kampung penyebab deforestasi hutan alam dengan rata-rata sekitar 6-8% per tahun. Hasil penelitian menunjukkan bahwa praktik ekoreligi masih dianut warga kampung dengan menjaga hutan tutupan (leuweung tutupan) untuk kegiatan subsistensi. Hipotesa yang dibangun adalah perubahan sosio-kultur terjadi pada masyarakat dengan membatasi kegiatan berladang di hutan tetapi lebih kepada kegiatan bertani di sawah ladang untuk mengelola lingkungan berkelanjutan. Pengurangan pada proses dan kegiatan upacara, yang semula delapan upacara daur ladang menjadi lima upacara daur sawah. Kegiatan profan lebih banyak pada pengembangan komoditas tanaman ekonomi di kebun-talun.

Kata kunci: Ekoreligi, Kampung, Lingkungan, Hutan, Tradisi
MAKNA TIGA IKON GAJAH DI DALAM GEREJA SAINT PIERRE AULNAY PRANCIS
Authors: Syofiadisna Panji
Published: July 2020

Abstract. Saint Pierre Aulnay Church is a Romanic-style church (Romanesque) that was built in the 12th century and is located in the Aquitaine Region, France. In this church, there are three elephant icons in the capital columns section. At the top of the icon, there is also an inscription in Roman that reads "HI SVNT ELEPHANTES" which means "this is an elephant-elephant". This unique sentence and elephant icon is not found in other Romanic-style churches in France. Elephants are not native to Europe, but elephant icons are produced in European (French) churches. During Medieval, some churches were found to have icons of animals or mythological creatures that were placed in several parts of the church. The icons of the animals are connected with the character of Jesus and are called bestiaries. The problem that will be answered in this research is what is the meaning contained in the elephant icon with the words "HI SVNT ELEPHANTES". The review in this study is the history of iconography and emphasizes the themes, concepts, styles, and meanings of icons. The theory used to analyze the problem put forward is the iconography and iconology of Erwin Panofsky. The results of this interpretation will be compared with the meaning of elephants in the archipelago at the same time.

Keywords: Bestiary, Church of Saint Pierre Aulnay, Elephant Icon, Medieval, French, Physiologus, Jesus

 

Abstrak. Gereja Saint Pierre Aulnay adalah gereja bergaya Romanik (Romanesque) yang dibangun pada abad ke-12 dan terletak di Region Aquitaine, Prancis. Di dalam gereja ini terdapat tiga ikon gajah pada bagian capital columns. Pada bagian atas ikon terdapat pula inskripsi dalam bahasa Romawi yang bertuliskan “HI SVNT ELEPHANTES” yang artinya “ini adalah gajah-gajah”. Uniknya kalimat dan ikon gajah ini tidak ditemukan pada gereja bergaya Romanik lain di Prancis. Gajah bukan hewan asli Eropa namun ikon gajah diproduksi di gereja Eropa (Prancis). Pada masa Medieval memang didapati sejumlah gereja memiliki ikon-ikon hewan atau makhluk mitologi yang ditempatkan pada beberapa bagian gereja. Ikon dari hewan-hewan itu terhubung dengan karakter Yesus dan dinamakan bestiary. Masalah yang akan dijawab pada penelitian ini yaitu apa makna yang terkandung pada ikon gajah dengan tulisan “HI SVNT ELEPHANTES”. Tinjauan dalam penelitian ini bersifat sejarah ikonografi dan ditekankan pada tema, konsep, gaya, serta makna dari ikon. Teori yang dipakai untuk menganalisis masalah yang dikemukakan adalah ikonografi dan ikonologi dari Erwin Panofsky. Hasil dari pemaknaan ini akan dibandingkan dengan makna gajah di nusantara pada masa yang sama.

Kata kunci: Bestiary, Gereja Saint Pierre Aulnay, Ikon Gajah, Medieval, Physiologus, Yesus
Is the Non-Justiciability of Economic and Socio-Cultural Rights in the Nigerian constitution Unassailable? Re-Examining Judicial Bypass from the Lens of South African and Indian Experiences
Authors: Faga Hemen Philip , Aloh Francis , Uguru Uchechukwu
Published: July 2020

The 1999 Constitution of the Federal Republic of Nigeria, as amended (CFRN) recognizes the entitlement of every Nigerian within its borders to enjoy economic and socio-cultural (ESC) rights under Fundamental Objectives and Directive Principles of State Policy. However, the constitution seemingly renders these ESC rights non-justiciable or unenforceable. This paper examines the efforts of the Nigerian judiciary to bypass the non-Justiciability provision to enforce ESC rights in Nigeria. It mainly investigates the role of judicial decisions in other similar jurisdictions such as South Africa and India in shaping the jurisprudence of the enforcement of ESC rights in Nigeria. Therefore, the paper adopts the comparative method and recommends that both the Nigerian legislature and the judiciary should follow the example of enforcement of ESC rights in these other jurisdictions.
Estudo das áreas de proteção permanente do rio Paraíba do Sul no município de Campos dos Goytacazes - RJ
Authors: Chrispim Zélia Maria Peixoto , De Oliveira Camille Pereira , Lacerda Jhonny , Araújo Ronaldo de Sousa
Published: July 2020

A pesquisa realizada teve como foco o estudo das áreas de mata ciliar no entorno do Rio Paraíba do Sul no município de Campos dos Goytacazes – RJ. Foi seguido o novo Código Florestal (Lei nº 12.651/2012) para a delimitação das margens dos cursos d’água para Áreas de Preservação Permanente (APPs). O objetivo da pesquisa foi verificar a situação atual dessas áreas à luz da legislação pertinente, tendo como parâmetro a disponibilidade de água em quantidade e qualidade. Quanto à metodologia foram realizadas as seguintes etapas: coleta de dados bibliográficos e documentais, como artigos, mapas, leis, imagens de satélite; revisão bibliográfica; quantificação das APPs; elaboração de gráficos; geração de mapa. Espera-se com esta pesquisa disponibilizar dados para contribuir com o planejamento e a gestão de recursos hídricos da região, garantindo assim a preservação das matas ciliares e o acesso aos diferentes usos da água. Verificou-se no estudo um grande distanciamento da quantidade de mata ciliar existente nas margens do rio Paraíba do Sul no município de Campos dos Goytacazes (apenas 9,20%), e a quantidade exigida pela lei federal. É necessário que se busquem medidas sustentáveis para a solução do problema do conflito entre as atividades agropecuárias e as necessidades ambientais regulamentadas em lei.
Kelayakan Usaha Budidaya Ayam Petelur (Analisis Biaya Manfaat dan BEP Pada UD KR Farm, Cilacap)
Authors: Pamungkas Muhamad Rijal
Published: July 2020

In the implementation of a livestock business, the use of production factors such as feed, efficiently becomes a benchmark in determining the profits derived from the business. This study aims (1) to determine the effect of feed prices on egg production (2) to determine the financial feasibility of the business in terms of cost and benefit analysis and how much BEP (Break Event Point) of laying hens. The data used are production data and feed prices for the period January 2019 - December 2019 at the KR Farm farm, Kuripan Kidul, Kesugihan, Cilacap. The data analysis technique uses regression analysis. The results of this study found that there was an effect of the price of feed on egg production, KR Farm said to be feasible where it obtained an R / C value of 2.69, while the value of B / C = 1.69, BEP (price) Rp. 438.49 items, BEP (production) of 454,281.74 items, and ROI of 1,69%. Suggestions that can be put forward in this study include, preferably the KR Farm can maintain its business that has good and decent performance so far, if seen from the price of feed it will further maintain its egg production, can also increase the profits obtained by increasing the number of laying hens in the future so that the increase in turnover obtained is Rp. 1,783,592,221 per month, and reduce the amount of BEP that can be done by increasing the selling price of eggs or by reducing total costs.Keywords:Â Â Â Â Â Â  Laying hens, Egg production, Feed prices, Cost and Benefit analysis, Break Even Point analysis
A Ligand-Directed Nitrophenol Carbonate for Transient In Situ Bioconjugation and Drug Delivery
Authors: Burt Anthony J. , Ahmadvand Parvaneh , Opp Larissa K. , Kang ChulHee , Mancini Rock
Published: July 2020

Here we report the first use of ligand-directed proximity accelerated bioconjugation chemistry in the tandem delivery and release of a therapeutic payload. To do this we designed a nitrophenol carbonate for ligand-directed in situ bioconjugation of a prodrug payload to a protein. The transient nature of our conjugation chemistry renders the protein a depot for time-dependent release of active drug following hydrolysis and self-immolation. In our model system, using an immunostimulant prodrug, biotin ligand, and avidin protein, we observe time-dependent release of bioavailable immunostimulant both spectroscopically and with an immune cell line over 48 h. Avidin co-crystalized with the biotin directing group verified the binding pose of the ligand and offered insight into the mechanism of in situ bioconjugation. Overall, this scaffold warrants further investigation for the time-dependent delivery of therapeutics and use in protein ligand pairs beyond biotin and avidin used for this work.
Linking Void and Interphase Evolution to Electrochemistry in Solid-State Batteries Using Operando X-Ray Tomography
Authors: Lewis John , Cortes Francisco Javier Quintero , Liu Yuhgene , Miers John C. , Verma Ankit , Vishnugopi Bairav S. , Tippens Jared , prakash dhruv , Marchese Thomas S. , Han Sang Yun , Lee Chanhee , Lee Hyun-Wook , Shevchenko Pavel , Carlo Francesco De , Saldana Christopher , Mukherjee Partha P. , McDowell Matthew T.
Published: July 2020

Despite progress in solid-state battery engineering, our understanding of the chemo-mechanical phenomena that govern electrochemical behavior and stability at solid-solid interfaces remains limited compared to solid-liquid interfaces. Here, we use operando synchrotron X-ray computed microtomography to investigate the evolution of lithium/solid-state electrolyte interfaces during battery cycling, revealing how the complex interplay between void formation, interphase growth, and volumetric changes determines cell behavior. Void formation during lithium stripping is directly visualized in symmetric cells, and the loss of contact at the interface between lithium and the solid-state electrolyte (Li10SnP2S12) is found to be the primary cause of cell failure. Reductive interphase formation within the solid-state electrolyte is simultaneously observed, and image segmentation reveals that the interphase is redox-active upon charge. At the cell level, we postulate that global volume changes and loss of stack pressure occur due to partial molar volume mismatches at either electrode. These results provide new insight into how chemo-mechanical phenomena can impact cell performance, which is necessary to understand for the development of solid-state batteries.
DRACON: Disconnected Graph Neural Network for Atom Mapping in Chemical Reactions
Authors: Nikitin Filipp , Isayev Olexandr , Strijov Vadim
Published: July 2020

Machine learning solved many challenging problems in computer-assisted synthesis prediction (CASP). We formulate a reaction prediction problem in terms of node-classification in a disconnected graph of source molecules and generalize a graph convolution neural network for disconnected graphs. Here we demonstrate that our approach can successfully predict reaction outcome and atom-mapping during a chemical transformation. A set of experiments using the USPTO dataset demonstrates excellent performance and interpretability of the proposed model. Implicitly learned latent vector representation of chemical reactions strongly correlates with the class of the chemical reaction. Reactions with similar templates group together in the latent vector space.
Multitarget Virtual Screening for Drug Repurposing in COVID19
Authors: Sorzano carlos oscar , Crisman Enrique , Carazo Jose Maria , leon rafael
Published: July 2020

Therapeutic or preventive research for coronavirus SARS-CoV2 is an extremely active topic of research since its outbreak in January 2020. In this paper we report the results from a virtual drug screening analysis that, to the best of our knowledge, is the widest work in terms of target proteins and compound library. Our study was focused on the repurposing of currently commercialized drugs, and especially those that can interact with multiple viral proteins and several binding sites within each protein. Additionally, we performed a second virtual screening analysis in which we compared our results to the predicted binding affinities for the drugs currently in clinical trials. We show that the best molecules in our screening compares favorably to those in clinical trials, suggesting their suitability for therapeutic or preventive applications.
Simplified Computational Model for Generating Biological Networks
Authors: Bailey Matthew , Ormrod Morley David , Wilson Mark
Published: July 2020

A method to generate and simulate biological networks is discussed. An expanded Wooten-Winer-Weaire bond switching methodsis proposed which allows fora distribution of node degrees in the network while conserving the mean average node degree.The networks are characterised in terms of their polygon structure and assortativities (a measureof local ordering). A wide range of experimental images are analysed and the underlying networksquantified in an analogous manner. Limitations in obtaining the network structure are discussed.A "network landscape" of the experimentally observed and simulated networks is constructed from the underlying metrics.The enhanced bond switching algorithm is able to generate networks spanning the full range of experimental observations.
Experimental Characterization of the Association of Nine Novel Cyclodextrin Derivatives with Two Guest Compounds
Authors: Kellett Kathryn , Slochower David , Schauperl Michael , Duggan Brendan M. , Gilson Michael
Published: July 2020

We investigate the binding of native β-cyclodextrin (β-CD) and eight novel β-CD derivatives with two different guest compounds, using isothermal calorimetry (ITC) and 2D NOESY NMR. In all cases, the stoichiometry is 1:1 and binding is exothermic. Overall, modifications at the 3’ position of β-CD, which is at the secondary face, weaken binding by several kJ/mol relative to native β-CD, while modifications at the 6’ position (primary face) maintain or somewhat reduce the binding affinity. The variations in binding enthalpy are larger than the variations in binding free energy, so entropy-enthalpy compensation is observed. Characterization of the bound conformations with NOESY NMR shows that the polar groups of the guests may be situated at either face, depending on the host molecule, and, in some cases, both orientations are populated. The present results were used in the SAMPL7 blinded prediction challenge whose results are detailed in the same special issue of JCAMD.
Comparison of Intraoperative and Postoperative morbidity between in situ and extra-abdominal Uterine repair at Cesarean delivery
Authors: Divya Ravikumar  , Sindhura Myneni  , Shanta Bhaskaran  , Gayathri Baluswamy  , Ramdas Praveena  , Vishnu Priya Veeraraghavan  , Preethi Gopakumar  , Parvathaneni Divya  , Surapaneni Krishna Mohan
Published: July 2020

In-situ and extra abdominal repair of uterine wound during cesarean section are two valid approaches. This study was carried out to compare intra operative and post operative morbidity in women undergoing caesarean delivery using these two techniques. This is a prospective interventional randomized controlled study. The study subjects include 170 women undergoing Lower segment caesarean section (LSCS) at Southern Railway HQ hospital, Chennai. Intra operative and post operative parameters were analysed in all the study subjects. In in-situ group, 12.6 % women experienced intra operative pain and 30.1% women in extra abdominal group. Intra operative nausea and vomiting was seen in 16.1% women in in-situ group and 28.9% women in extra abdominal group. 1.1% women in in-situ had post-operative febrile morbidity and 8.4 % had in extra abdominal group. The median fall in haemoglobin was 1.30 g/dL and 1.40 g/dL in in-situ and extra abdominal group respectively. In-situ repair of the uterine wound at cesarean delivery is associated with lesser incidence of intra operative pain , intra operative nausea or vomiting and post operative febrile morbidity compared to extra abdominal repair technique.
Cisplatin-Induced Peripheral Neuropathy: An Observational Descriptive Study
Authors: Anjol Kurian  , Bittu Babu  , Benson Punnoose  , Chinju Susan Chacko  , Mallikarjuna Rao  , Sharad Chand  , Vinay B C  , Nandakumar U P
Published: July 2020

Peripheral neurotoxicity is a major adverse effect of cisplatin chemotherapy. A prospective observational study was conducted among 200 cancer patients who received cisplatin between October 2017 and March 2018 to evaluate the occurrence, causality and severity of cisplatin induced peripheral neuropathy. A suitable data collection form was used to record patient information required for the study. Peripheral neuropathy was assessed using the National Cancer Institute- Common Terminology Criteria for Adverse Events (NCI-CTCAE). As per the results, 19 (9.5%) patients developed peripheral neuropathy after receiving cisplatin therapy. Peripheral neuropathy was reported higher in males (84.2%) compared to females (15.7%) and more within the age group of 58-65 years (38.6%). Most of the patients developed Grade I neuropathy (84.2%), followed by Grade II neuropathy (15.7%). The study concluded that the severity of peripheral neuropathy increases with higher cumulative doses of cisplatin.
Recent developments in orally disintegrating mini tablets
Authors: Sachin Sarashetti  , Vikas Jain  , Gowda D V  , Pooja Mallya  , Satish Babu
Published: July 2020

Solid oral dosage forms are most suitable dosage forms; preferably tablets are widely accepted by people of different age groups. Mini tablets are tablets with a diameter equal to or smaller than 2–3 mm. Mini tablets are multiple unit dosage forms and are advantageous than pellets or any other oral dosage forms as they are easy to manufacture and stability problems are less. Many types of mini tablets are there like bio adhesive mini tablets, pH responsive mini tablets, gastro retentive mini tablets, paediatric mini tablets, oral disintegrating mini tablets. Current ODT developments meet multiple pharmaceutical and patient needs, including better life-cycle management to easy treatment for paediatric, geriatric and psychiatric dysphagic patients. Orally disintegrating dosage forms are X suitable for patients, especially who find it inconvenient to swallow traditional tablets and capsules with an 8-oz glass of water for one reason or another. These essentially reduce the variation between subjects. Mini tablets which disintegrate orally can be evaluated by testing for dissolution, disintegrating testing and hardness. The need for non-invasive delivery systems continues due to the poor acceptance and enforcement by patients of current delivery schemes, limited market space for drug companies and product usage, coupled with high disease management costs. The review emphasizes on advantages of mini tablets, types, methods of manufacturing and modes of administration and evaluation of mini tablets.
Value of stereoelectroencephalography (SEEG)-guided radiofrequency thermocoagulation in treating drug-resistant focal epilepsy
Authors: Bai Jianjun , Zhou Wenjing , Wang Haixiang , Zhang Bingqing , Lin Jiuluan , Song Xiancheng , Li Jia , Ruan Jing , Liu Yiou , Shi Jie , He Jing , Feng Qian
Published: July 2020

Stereoelectroencephalography (SEEG) has been widely used in the presurgical evaluation of patients with medically intractable epilepsy. In the past, SEEG was commonly used as a method for mapping and localizing the epileptogenic zone (EZ). Since 2004, several studies have been conducted to examine the effectiveness of SEEG-guided radiofrequency thermocoagulation (RF-TC) in treating refractory epilepsy. However, the seizure-free and responder rates varied greatly across studies. We aimed to analyze the outcome of 56 patients who were treated with SEEG-guided RF-TC to evaluate the effectiveness of this treatment. SEEG-guided RF-TC can be considered as a treatment for refractory epilepsy. However, due to its limited efficacy, SEEG-guided RF-TC might be regarded as a temporary treatment performed under SEEG rather than a promising treatment for refractory epilepsy.
Individual differences of maladaptive brain changes in migraine and their relationship with differential effectiveness of treatments
Authors: von Deneen Karen M. , Zhao Ling , Liu Jixin
Published: July 2020

Migraine is a difficult disorder to identify with regard to its pathophysiological mechanisms, and its treatment has been primarily difficult owing to interindividual differences. Substantial rates of nonresponsiveness to medications are common, making migraine treatment complicated. In this review, we systematically analyzed recent studies concerning neuroimaging findings regarding the neurophysiology of migraine. We linked the current imaging research with anecdotal evidence from interindividual factors such as duration and pain intensity of migraine, age, gender, hormonal interplay, and genetics. These factors suggested the use of nonpharmacological therapies such as transcranial magnetic stimulation, transcranial direct current stimulation, and placebo therapy for the treatment of migraine. Finally, we discussed how interindividual differences are related to such nondrug treatments.
A review on the ongoing quest for a pain signature in the human brain
Authors: Su Qian , Song Yingchao , Zhao Rui , Liang Meng
Published: July 2020

Developing an objective biomarker for pain assessment is crucial for understanding neural coding mechanisms of pain in the human brain as well as for effective treatment of pain disorders. Neuroimaging techniques have been proven to be powerful tools in the ongoing quest for a pain signature in the human brain. Although there is still a long way to go before achieving a truly successful pain signature based on neuroimaging techniques, important progresses have been made through great efforts in the last two decades by the Pain Society. Here, we focus on neural responses to transient painful stimuli in healthy people, and review the relevant studies on the identification of a neuroimaging signature for pain.
Programa de Formación en Salud Pública para Trabajadores de Salud en la Frontera Brasil-Uruguay
Authors: Peres Frederico , Blanco Centurión Maria Pasionaria , Silva Juliana Monteiro Bastos da , Brandão Ana Laura , Verani José Fernando de Souza , Buglioli Marisa , Ortega Elizabeth , Brescia Adriana
Published: July 2020

El principal objetivo del Programa de Formación en Salud Pública para la Frontera Brasil-Uruguay fue fortalecer las capacidades formativas locales en salud pública a través del desarrollo de habilidades y competencias junto a trabajadores de salud de cuatro zonas fronterizas. El diseño metodológico del Programa, basado en talleres docentes con aplicación de metodologías activas de la formación en salud y mediados por tecnologías educacionales, favoreció la organización de un espacio dialógico permanente entre docentes, gestores y actores de la práctica de ambos países que, entre 2017 y 2018, resultó en: a) el desarrollo de capacidades locales para el mapeo de los principales problemas de vigilancia de la salud en las cuatro zonas fronterizas participantes; b) la discusión de los límites y perspectivas de acción de los servicios de salud existentes en ambos países, dentro de los principios y lineamientos del campo de la salud pública; c) la apropiación de herramientas y procesos pedagógicos que permitieron la incorporación del aspecto de salud pública y de la vigilancia de la salud en los diferentes procesos y espacios organizativos del sector salud local; y d) la construcción de una capacidad permanente para el desarrollo de habilidades y competencias junto a trabajadores del sector salud, en una lógica de educación permanente en salud. Los logros del Programa y sus contribuciones a los servicios de salud locales lo habilitan, de manera efectiva, como acción estratégica para el fortalecimiento de capacidades formativas y de investigación en la frontera Brasil-Uruguay.
Corporate Social Responsibility and its Nexus with Firm Performance and Institutional Ownership: An Emerging Market Context
Authors: Amna Noor  , Muhammad Farooq  , Mahwish Yamin  , Saleh Nawaz Khan
Published: July 2020

Either corporate social responsibility (CSR) is paramount for the firms or not, is a matter of 

question since long. The present study analyzes this relationship in the context of moderating 

role of Institutional ownership (IO). Firm performance is measured through accounting and 

market value measures. Leverage, firm age, firm size, and log of sales revenue used as a control 

variables. Through applying panel data techniques, findings demonstrate insignificant positive 

association between CSR and firm performance. It shows that stakeholder could not assign value 

to firms spending as a CSR. This could be the reason that customers are not much aware about 

firms CSR activities hence, firms fail to capitalize their spending as an investment. Institutional 

Ownership (IO) reveals negative insignificant association with all profitability measures except 

Tobin’s Q where this relationship is significant. This significant negative relationship supports 

the agency theory and presence of strategic alliance hypotheses between influential institutional 

owners and internal management that leads to lower firm performance. The interaction variable 

of CSR and IO show positive but insignificant relationship with firm performance by all means.
STUDY OF EFFECT Al2O3 NANOPARTICLES ON ELECTRICAL PROPERTIES OF EPOXY REINFORCEMENT BY CARBON FIBERS HYBRID COMPOSITES
Authors: Khdair W. Y. , Salman S. A. , Khdair Z. T.
Published: July 2020

In this paper was investigation the electrical properties of the epoxy "Hybrid Composites" as a function of a frequency. The composites constituents were epoxy using a matrix with reinforcement ratio (1:3) and volume fractions as (25% wt). The "Hybrid  Composite" samples  were prepared by addition alumina  nanoparticles on the epoxy composites reinforced by carbon  fibers with different  volume fractions (0.1,0.3,0.5,0.7)w%  by "Hand Lay-Up Molding". The experiments were performed to measure the electrical properties "Dielectric Constant, Dissipation Factor and Electrical Conductivity" in frequency range (10Hz-1MHz). The study showed that  the reinforcement process resulted in an increase in the dielectric constant values of all manufactured models, and the addition of alumina nanoparticles leads to a decrease in the values of both the dielectric constant and the dielectric loss factor with increasing frequency and for all samples and for all values listed. Alternating electrical conductivity values increase significantly with increasing frequency and for all samples when alumina nanoparticles are added.
Review on use of macro algae (seaweed) in fish nutrition
Authors: Saleh Hamed H.E.
Published: July 2020

Currently, the search is on for alternative sources of feed ingredients, the main reasons being escalated cost and uncertainty of constant supply of common feed ingredients. The importance of algae as a potential substitute protein source for cultured fish feeding has been documented in recent years. Seaweeds are receiving consideration for their high protein value, essential amino acid content, vitamins and trace metals in fish feeding. As well as marine macro algae could be a potential low-cost source of protein for fish. Moreover, the economic comparison of feed cost indicated that increasing level of fresh and dried gut weed in alternative feeding treatments, commercial feed used for fish growth was reduced leading to significantly reduction of feed cost. Use macro algae (seaweed) in fish diets may improves growth parameters, feed efficiency, physiological activity, carcass quality, disease resistance and reduced stress response. This review describes effects of use macro algae (seaweed) in diets on growth performance of fish.
Grouping of Tectonic Earthquakes in the Province of Nusa Tenggara Barat Indonesia with K-Means Cluster Method Approach and Determination of Distribution Type
Authors: Wattimanela Henry Junus
Published: July 2020

The earthquake is one of the natural disasters that is destructive and claimed lives at a certain magnitude and depth. Indonesia is an earthquake-prone area because it is in the area of major tectonic plates. Province of Nusa Tenggara Barat is one of the 34 provinces in Indonesia which is earthquake prone. In this research, earthquake grouping will be carried out in the Province of Nusa Tenggara Barat using the K-Means cluster approach. Furthermore, using the Kolmogorov-Smirnov test the type of distribution is determined for each group variable resulting from the cluster process. The data used was the 2018 earthquake data in West Nusa Tenggara Province, sourced from the USGS earthquake catalog. The software used in this research process is SPSS, GMT, and Matlab, respectively. The results of this study are expected to be used as a reference for the Government of Nusa Tenggara Barat Province and surrounding areas related to earthquake disaster mitigation, especially evaluation of spatial and regional.
Peningkatan Life Skills Melalui Pembelajaran IPA Pendekatan Scientific Pada Siswa MI
Authors: Khairiyah Ummu
Published: July 2020

This study is aimed at improving Life Skills through the application of scientific approach. The stages of this study is to analyze the problems in school, develop scientific approach-based learning tools, and use learning tools. The subjects of this study were 30 MI students on the environmental pollution subject matter. In this study, data collection techniques used qualitative and quantitative descriptive analysis. The results showed that life skills consisting of thinking skills, academic skills and social skills increased after being given an activity through science teaching based on a scientific approach.Keywords: life skills, scientific approach, learning tools
Pendekatan-Pendekatan Dalam Mengembangkan Kurikulum Pendidikan Dasar
Authors: Fithriyah Musa’adatul
Published: July 2020

The curriculum is designed to achieve a dynamic education. It should be developed especially in keeping up with any scientific and technological development. The basic education curriculum is aimed at developing and designing a new curriculum in addition to changing, improving, implementing and even taking control of the basic curriculum. In regard with the curriculum development, it should be implemented through some systematic approaches to produce a better curriculum in accordance with the objectives of national education. The approaches of developing basic education curriculum are carried out by implementing appropriate strategies and methods by taking into account the   systematic development steps to produce a better curriculum, especially that is in line with the basic education level. The use of an approach or orientation generally determines the form and pattern used by the curriculum. The approaches that could be used in the development of basic education curriculum are, among others: 1) the subjectmatter approach, 2) the integrative approach, 3) the centralized approach, 4) the decentralized approach, 5) the social reconstruction approach, 6) the technological approach, 7) the humanistic approach. Based on the study of several approaches used in the development of the Basic Education curriculum, it is expected that teachers could develop curriculum and produce a better curriculum especially the Basic Education curriculum to achieve the expected educational goals.Keywords: Approach, curriculum development, basic education