bluuebunny/crossref_metadata_2025 huggingface dataset:
Absolute Eosinophil Count May be One of the Most Optimal Peripheral Blood Markers to Identify Risk of Immune-Related Adverse Events in Advanced Malignant Tumors Treated with PD-1/PD-L1 Inhibitors.
Authors: Ma Yan , Ma Xiao , Wang Jingting , Wu Shanshan , Wang Jing , Cao Bangwei
Published: May 2021

Background To investigate the predictive value of serum biomarkers such as AEC、Neutrophil- lymphocyte ratio (NLR) and platelets - lymphocyte ratio(PLR) on immune-related adverse events (irAEs) during the PD-1/PD-L1 inhibitors treatment in advanced malignant tumors. Methods We retrospectively analyzed 95 advanced cancer patients treated with PD-1/PD-L1 inhibitor from January 1, 2017 to May 1, 2020 in our cancer center. Then, the associations between irAEs and PD-1/PD-L1 inhibitors respond was analyzed and the predictive value of serum biomarkers on irAEs occurrence risk was evaluated. Results The incidence of irAEs was 55.8%. There were no statistically significant differences between the irAEs group and the no-irAEs group in Objective response rate (ORR) and Disease control rate (DCR), but the Landmark analysis showed that the irAEs group had better survival after 120 days compared with the no-irAEs group. The incidence of irAEs in the high-AEC and low-NLR groups was greater than that in the low-AEC and high-NLR groups. Univariate logistic analysis results showed that low-NLR, ECOG (0-1) and High-AEC were risk factors for irAEs. However, multivariate logistic analysis not only shows that AEC is an independent factor of irAEs, but also suggests that good ECOG may be more prone to irAEs . Conclusions IrAEs may show a survival benefit to a certain extent. Baseline AEC is a strong predictor of irAEs in the treatment of PD-1/PD-L1 inhibitors.
Weight Change of Younger and Older Early Breast Cancer Patients – A Meta Regression
Authors: Chow Ronald , Chiu Leonard , Ro Vicky , Lock Michael
Published: May 2021

Introduction: Weight gain has a major impact on the quality of life of breast cancer patients. Post treatment weight gain can impact on primary endpoints such as recurrence, death, self identity and the ability to return to work. Parameters thought to impact on weight gain include menopausal status, age and chemotherapy regimen. Using meta-regression, we studied the effect of age on weight change, by menopausal status and chemotherapy regimen.Methods: 24 studies were identified, and extracted for weight change, mean/median age, menopausal status and chemotherapy regimen. A meta-regression was performed, using a random-effects DerSimonian and Laird model for high heterogeneity and fixed-effects inverse-variance model for low heterogeneity. Subgroup analyses were conducted, by menopausal status and chemotherapy regimen. P-values less than 0.05 were considered statistically significant.Results: There exists no relationship between weight change and age (β = 0.00; p = 0.987). Stratifying by menopausal status and chemotherapy regimens, there likewise was no relationship. Conclusion: Management of weight gain due to chemotherapy has been focused on relatively young women where a higher mortality and recurrence has been found. However, our results suggest that age should not be used to differentiate care in these patients.
Integrative Analysis of lncRNA-mRNA Signature Reveals a Functional lincRNA in Triple-negative Breast Cancer
Authors: Jia Yan , Jia Yongsheng , Shi Yehui , Zhao Weipeng , Wang Xiaorui , Tong Zhongsheng , Song Yueshuai
Published: May 2021

Purpose: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer. It is still unclear that the mechanisms by which long non-coding RNA (lncRNA) regulates tumorigenesis of TNBC. In this study, we explored the function and regulation of lncRNA in TNBC. Methods: The differentially expressed and overlapped lncRNAs were obtained from two microarray datasets of breast cancer. The Cancer Genome Atlas data was applied to validate the roles of top differentially expressed lncRNAs. The potential relationship among lncRNAs, miRNAs, and mRNAs and the effects of them on the TNBC tumorigenesis were further explored through multiple bioinformatic methods. Results: Long intergenic non-protein coding RNA 1351 (LINC01351) was first discovered to play an oncogenic role in TNBC. The highly expressed LINC01351 was significantly related to poor prognosis, aggressive subtypes, advanced stages and metastasis of breast cancer. LINC01351 was found to negatively regulate ELK4 which was involved in the transcriptional regulation in cancer. The high expression of ELK4 showed favorable prognosis of patients with basal-like 1 subtype and luminal androgen receptor subtype of TNBC.Conclusion: The dysregulation of LINC01351 played an important role in triple-negative breast cancer. LINC01351 could be a poor prognostic marker and a potential target for patients with TNBC.
Developing cardiometabolic risk classifiers for youth using handgrip strength, anthropometrics, and demographics: a machine learning approach leveraging National Health and Nutrition Examination Survey Data
Authors: Ajisafe Toyin
Published: May 2021

Background Handgrip strength associates with cardiometabolic (CMB) risk. Health-related physical fitness (HRPF) testing in schools do not explicitly predict CMB disease risk, and commonly engender anxiety, teasing and taunting by peers. Further, school-based screening for hyperinsulinemia using acanthosis nigricans likely misses nascent CMB risk factors like dyslipidemia. This study examined the feasibility of leveraging anthropometrics, demographics, and handgrip strength data to build optimal CMB risk classifiers. Methods The 2011-2014 National Health and Nutrition Examination Survey data from participants aged 12-18 years (n = 402; 205 males) (15.4 ± 1.8 years; 167.4 ± 9.1 cm; 73.2 ± 21.5 kg) who performed bilateral handgrip strength and CMB testing was leveraged. CMB risk was delineated as clustering of three or more risk factors across weight status, mean systolic, mean diastolic, HDL-cholesterol, LDL-cholesterol, total cholesterol, triglycerides, fasting glucose and HOMA-IR. 80% of the balanced dataset was used to train several models (e.g., Decision Tree and K-Nearest Neighbors (KNN)), while 20% was retained for further validation. There were 18 initial features, including age, sex, race, BMI, and combined handgrip strength. SelectKBest, Recurrent Feature Elimination, and Random Forest were deployed to identify the most salient features. Results Resulting models were evaluated using performance metrics such as Area Under the Curve (AUC), recall and precision. The most salient model was a Quadratic Discriminant model involving five features, namely number of people in household, annual household income, number of children 5 years or younger, combined handgrip strength, and waist circumference. When deployed, the model accurately classified 83% and 93% of the positive and negative classes within the test data, respectively (accuracy = 81.7%; AUC = 0.87; Recall = 0.91; Precision = 0.81; F-Measure = 0.92). Conclusions Findings demonstrate demographics, anthropometrics, and handgrip strength can be leveraged (using machine learning techniques) to accurately predict and optimally identify nascent CMB risk in youth while mitigating peer shaming and optimizing student participation in HRPF surveillance protocols in schools. Additional studies are needed to externally validate resulting models and investigate related effects on participation in HRPF testing and CMB risk detection among children and youth.
Osahs Patients With CPAP Complained of Multiple Side Effects: A Meta-analysis of Randomized Trials
Authors: Zhu Chunxue , Liu Qing , Lu Qinyuan , Wang Yicheng , Liu Chengyu , Zhang Xilong , Huang Hanpeng
Published: May 2021

PURPOSE:CPAP (Continuous Positive Airway Pressure) is the "gold standard" treatment for OSAHS (Obstructive Sleep Apnea Hypopnea Syndrome). However, its compliance is only 30% to 70%. Much of the compliance reduction depends on its side effects. This study aimed to perform a meta-analysis of all randomized trials that statistically analyzed the side effects of CPAP.METHODS:The Cochrane, Embase, and Pubmed were searched for relevant studies from inception until September 2019 with the following terms: "OSAHS" and "CPAP" and "side effects". Two reviewers independently extracted data. Meta-analyses on adverse outcomes were calculated with a frequentist approach. Summary sensitivity analysis, risk of bias, and 95%CIs were also obtained. All statistical analyses were performed with R package metaRESULTS:All side effects investigated can be broadly classified into four categories including respiratory tract discomfort, discomfort of the mask, psychological pressure and specific gastrointestinal symptoms. Overall, the random effects meta-analysis revealed that dry symptoms (0.23;95% CI, 0.16-0.32), gas leakage (0.17;95% CI, 0.10-0.27) and sleep disorders (0.14;95% CI, 0.11-0.18) were associated with a higher incidence. Another intergroup analysis showed statistically significant differences in the incidence of dryness and sleep disturbance (0.23;95% CI, 0.16-0.32 vs. 0.14;95% CI, 0.11-0.18, respectively; P =.04)CONCLUSION:Side effects of CPAP are multifaceted and occur in combination with high probability. The impact of specific side effects on compliance needs to be further investigated in clinical data. Meanwhile, medical workers need to consider further the impact of side effects and timely adjust relevant treatment plans or nursing service in the clinic.
From Clause to Function: Texts Analysis Using Systemic Functional Linguistics Theory and Its Pedagogical Implication in Language Teaching
Authors: Darong Hieronimus Canggung
Published: May 2021

Using Systemic Functional Linguistics (SFL) theory, this study was an attempt to investigate the metafunctions of language which are realized by register category of field, tenor, and mode existing simultaneously in texts. Employing qualitative approach with the use of discourse semantics analysis, two different selected newspaper texts were purposefully chosen as the source of data. Following the orientation of SFL, the writer modified the texts into some sentences and clauses which were subsequently analysed and compared regarding the objectives in question. The result of analysis shows that the field of texts was mostly concerned with physical actions and events employing both direct and indirect speech for the sake of information. Meanwhile, in terms of mode, Text I was more rhetoric and more detail in describing the event than text II. Yet, the level of modality in both texts was low and low in which there were not many actions of getting other people to do things. Aside from those two, this analysis revealed that the mode of both texts mostly used anaphoric types of referential cohesion indicating written mode. In the meantime, Text I had more number of conjunctions implying more explanative in giving information and cause and effect relation of the information. Of greater importance of this finding was that a paradigmatic description of context implying a meaning, system, and metafunctions of language and its pedagogical implication in language teaching.
Brief ELT in Digital Classroom for Lazy Creative Lecturers (Option After Post Pandemic Recovery): Lecturers’ Perspectives
Authors: Triana Yunika , Nugroho Arif
Published: May 2021

This paper provides essential information for lecturers and educational institutions to think creatively in teaching English via online. The rapid development of Information and Communication Technology (ICT) and the Covid-19 emergency made lecturers and educational institutions think harder than usual. Higher education has used a powerful learning pattern and strategic policy to overcome the problem namely structure and unstructured online learning platform. The research aimed to find what platform is suitable in higher education and how lecturers create particular activity using HOTs to make students to think creatively. It also underlined that this new platform provides useful options that not only offers material delivery features but also an interactive communication feature. There were selected 10 lecturers of ELT in higher education level being interviewed and separated into two group users of structured and unstructured digital learning models. The distribution was based on their experience on teaching English using both models. This study analyzed interviews with lecturers who are experienced in usage of structured and unstructured online Learning platform. The findings were discussed by resuming and then drawing the conclusion through interpreting the findings. The findings from these data illustrated that these new learning patterns had a significant impact on students' cognitive and psychomotor abilities. Moreover, this model also significantly affected institution quality control.
Lexical Richness in Scientific Journal Articles: A Comparison between ESL and EFL Writers
Authors: Choemue Sumit , Bram Barli
Published: May 2021

This study investigated lexical richness in research articles published by writers of ESL and EFL in the ASEAN countries. The question was whether there were any significant similarities and differences in terms of lexical richness in research articles between these two groups. The researchers employed three different lexical measures to find out the answer: (a) lexical density (how many content words were used), (b) lexical diversity (how wide-ranging words were used), and (c) lexical sophistication (how many advanced and unusual words were used). The primary data consisted of 40 research articles published by two ESL countries, namely Malaysia and the Philippines, and the other two EFL countries: Indonesia and Thailand and were taken from the Directory of Open Access Journals (DOAJ) and Bielefeld Academic Search Engine (BASE). The researchers analyzed the data by utilizing three measurement tools namely CLAWS Tagger, Moving-Average-Type-Token-Ratio (MATTR), and VocabProfiler, and compared the results between ESL and EFL using the Mann-Whitney U test. Interestingly, despite different total tokens in several aspects, the data analysis results indicated no significant difference between ESL and EFL writers in terms of lexical richness and how they employed vocabulary in their research articles. This study further discussed factors influencing the use of vocabulary by two groups and concluded with limitations of the study and future research directions.
Experimental estimation of the damping ratio of metallic foam sandwich panels with sand intrusions
Authors: Farhadi Sasan , Civera Marco
Published: May 2021

The interest to use steel foam sandwich structures is expanding in various industrial applications, and more attention is paid to improve the properties of these materials. However, liquid and solid intrusions can severely hamper their useful characteristics. This study aims to provide an experimental investigation on the potential of steel foam (hollow sphere) sandwich specimens to operate as passive dampers in flexural vibration and to preserve their capabilities when affected by the intrusion of external particles. The authors utilized two different experimental examinations, random noise (white noise) and impact (hammer) tests. The specimens consist of a hollow sphere foam core sandwiched between two mild steel sheets, bonded with a thermosetting epoxy resin. To simulate the intrusions of granular materials in operating conditions, the metallic foam cores of the samples were partially filled with different percentages of quartz sand particles. The two-phase specimens were then compared to the pristine (single-phase) ones. The resulting estimates of the vibrational damping ratio for single and double-phase metallic foam specimens were used to calibrate the respective Finite Element models, which proved to be suitable for replicating the damping characteristics of the specimens.
Experimental study on infiltration pattern: opportunities for sustainable management in the Northern region of India
Authors: Kumar Vikram , Chaplot Barkha , Omar Padam Jee , S. Shaktibala , Md. Azamathulla H.
Published: May 2021

The infiltration process plays a key role in designing groundwater recharge, irrigation, and drainage systems, and contamination evaluation is controlled by numerous factors, among which soil physical properties and land use & land cover (LULC) are the prime factors. A comprehensive understanding of the spatial water infiltration characteristics over the soil which is site-specific and more complex due to non-uniformity could enhance the agriculture water use efficiency and mitigate water-related issues. The present study deals with the measurement of field infiltration characteristics using a mini disc infiltrometer in all 24 blocks of Gaya districts, Bihar, which covers a wide spectrum of soil types. Results showed that the average cumulative infiltration rate (IR) for the study area varies between 0.38 and 2.20 cm/min with an average rate of 1.16 cm/min. The initial IR among all blocks was found to be high but decreased gradually with each successive reading. Moreover, the land use under forest cumulative IR was more than the cumulative IR for urban and grassland. Eight blocks (33.3%) have an IR more than the average infiltration of the area which is good for storing the water in the aquifer and suggested constructing a recharge structure. Further investigation revealed a small IR in the inundated area, because of the maximum soil water table. The ready-to-use map showing the IR for the district is prepared which could be used by any decision-taking during the high or low rainfall, understanding the hydrological process, development of any reference guide for farmers for increasing the agriculture productivity and soil-water management.
Inflammation, Chronic Diseases and â€œBone Qualityâ€
Authors: Rahman Perdana Aditya
Published: May 2021

Inflammation, Chronic Diseases and â€œBone Qualityâ€
Challenges in Diagnostic and Management of Nephritic Syndrome in Diabetic Nephropathy Patient: a Case Report
Authors: Novitasari Adinda Dian , Samsu Nur
Published: May 2021

The clinical presentation of patients with acute glomerulonephritis (GN) varies widely, from asymptomatic to clinical presentations of acute kidney injury (AKI), edema, and hypertension. Diagnosis of GN in patients with diabetic nephropathy (DN) is a challenge due to pre-existing edema, hypertension, and decreased renal function. Likewise in terms of management of steroid immunosuppressants related to blood sugar regulation. It has been reported that 35-year-old male patients with diabetes mellitus (DM) with DN whose kidney function deteriorated rapidly. The patient complained of cola-red urine and decreased urine volume the day before admission. Physical examination showed blood pressure of 160/95 mmHg, bilateral leg edema, active chronic ulcer in the left lower leg, hemoglobin level was 8.7 g / dl, leukocytes 17.400 / ul, serum urea level 96 mg / dl, serum creatinine level 7.01 mg / dl, ASTO titer + 800 IU / ml, macroscopic hematuria, and albuminuria +4 on urinalysis. Ultrasonography revealed enlarged kidney size and signs of acute renal inflammation. Based on these data the patient was diagnosed clinically as rapidly progressive GN due to post-infectious GN. The patient received 3 days of pulse methyl prednisolone therapy continued orally, blood sugar regulation with insulin, RAS blockers, intravenous antibiotics and ulcer debridement. After 1 week of therapy, clinical and laboratory improvements were found and at the next follow-up renal function returned to baseline about 2 weeks later.
Sounding identity. Music-making in eighteenth-century Dutch noble homes
Authors: Van Son Joris
Published: May 2021

From the 1980s, music-making in eighteenth-century Dutch homes has received increasing scholarly attention, particularly in studies on noble families. While these studies shed light on the role of music in noble homes, they do not venture much beyond establishing a factual historical narrative. In contrast, recent studies on eighteenth- and nineteenth-century English domestic musical culture demonstrate a more interpretive approach by focusing on class, gender and national identity. This raises the question what role these issues play in the Dutch context. Taking a similar approach, this article revisits case studies on music-making in the homes of the Van Reede family and Belle van Zuylen (1740-1805), of the Van Tuyll family, to illuminate how music related to different aspects of their identity. This study shows how their musical practices confirmed and challenged elite gender conventions, as well as resonated with and transcended their various national identities. These findings suggest that identity construction is a useful framework for studying elite music-making, helping us understand what music might have meant for those involved.
Insignia Summorum Principum. Using symbols of power in pursuit of higher rank and status by German prince-electors and Polish-Lithuanian princes
Authors: Rogulski Jakub
Published: May 2021

In 1680 an anonymous Polonus Borussus composed a treatise suggesting the equal status between the German imperial princes and the Polish-Lithuanian princely families in terms of their symbolism. Using it as a starting point, the article investigates the way in which these elites expressed their real power and political ambitions in a similar manner. By comparing the Electors of Brandenburg and the houses of Radziwiłł, Wis´niowiecki and Sanguszko it shows that, first, Polonus Borussus did not exaggerate too much when he hinted at the ‘symbolic’ equality of the German electors and the Polish-Lithuanian princes; and second, that these elites differed from each other in two aspects: the primary audiences of their symbolic practices (peers in the case of the German princes as opposed to the middling nobility, the antagonist of the Polish-Lithuanian princes) as well as the potential to exploit symbols (the ‘symbolic audacity’ of the Polish-Lithuanian princes contrasting with the ‘confirmative’ use of the German princes).
Ease of Doing Business Index: An Analysis of Investors Practical View
Authors: Babatunde Shakirat Adepeju , Ajape Mohammed Kayode , Isa Kabir Dandago , Kuye Owolabi , Omolehinwa Eddy Olajide , Muritala Shefiu Abiodun
Published: May 2021

Abstract: This study investigates the effect of Ease of Doing Business Index (EDBI) on Return on Investment (ROI). The study employs a cross-sectional survey design covering five years from 2015 to 2019. The sample is 47 registered companies with the Lagos Chamber of Commerce and Industry, which is the most representative of the organised private sector group in Nigeria. The study adopts descriptive and linear regression statistical analysis. Findings show a statistically significant negative effect of Government policy continuity. The government procurement process, Raw materials availability and Quality of workforce show adverse effects. Traffic and transportation management, power supply and Security infrastructure show insignificant effect on ROI. Hence, findings indicate that Government procurement process is inimical to ease of doing business in Nigeria despite the government improvement efforts. Since government efforts are insufficient, the World Bank should incorporate private sector ideals into EDBI to create a synergy a robust EDBI. Keywords: Ease of Doing Business, ease of doing business index, return on investment, investors, World Bank.      Ease of Doing Business Index: Sebuah Analisis terhadap Pandangan Praktis InvestorAbstrak: Penelitian ini menginvestigasi pengaruh Ease of Doing Business Index (EDBI) terhadap Return on Investment (ROI). Penelitian ini menggunakan desain survei cross-sectional dari tahun 2015 sampai dengan tahun 2019. Sampel penelitian ini adalah 47 perusahaan yang terdaftar di Lagos Chamber of Commerce and Industry. Penelitian ini menggunakan analisis deskriptif dan statistik regresi linear. Dari berbagai elemen EDBI, temuan dari penelitian ini menunjukkan adanya pengaruh negatif yang signifikan antara keterlanjutan kebijakan pemerintah terhadap ROI. Proses pengadaan pemerintah, ketersediaan bahan mentah, dan kualitas tenaga kerja menunjukkan pengaruh berkebalikan dengan ROI. Lalu lintas dan manajemen transportasi, supply listrik, dan infrastruktur keamanan menunjukkan pengaruh tidak signifikan terhadap ROI. Usaha pemerintah dalam meningkatkan proses pengaadaan pemerintah masih belum memadai karena masih kecilnya pengaruh terhadap EDBI Nigeria. World Bank sebaiknya memasukkan pengaruh sektor privat dalam indikator EDBI sebagai upaya menciptakan sinergi antara pemerintah dan sektor privat untuk peningkatan EDBI dan dampaknya pada ekonomi. Kata kunci: Ease of Doing Business, indeks kemudahan berbisnis, pengembalian investasi, investor, Bank Dunia
Comparative Analysis of the Determinant Factors of Return on Assets between Islamic Commercial Banks (BUS) and Islamic Business Units (UUS)
Authors: Nugroho Lucky , Mastur Akhmad Amien , Ulfa Ulfa , Wahyono Tri , Soeharjoto Soeharjoto
Published: May 2021

Abstract: This study aimed to analyze and compare the factors that affect the return on assets (ROA) of Islamic commercial banks (BUS) and Islamic business units (UUS). This study’s independent variables are NPF, FDR, and MSMEs. The study used the quantitative method, with multiple regression approaches in analyzing the research data. The results of this study show that the BUS NPF has a negative and significant impact on the BUS ROA; the BUS FDR has a positive and insignificant impact on the BUS ROA; the BUS MSMEs  portion of the BUS loan distribution has a negative and insignificant impact on the BUS ROA; the UUS NPF has a negative and significant impact on the UUS ROA; the UUS FDR has a positive and significant impact on the UUS ROA; and the MSMEs’ portion of the UUS loan distribution has a positive and significant impact on the UUS ROA.Keywords: BUS, UUS, Return on Asset, Non-Performing Financie, Financing to Deposit Ratio, MSME financing Analisis Perbandingan Determinan Faktor Return on Asset antara Bank Umum Syariah (BUS) dengan Unit Usaha Syariah (UUS)Abstrak: Penelitian ini bertujuan untuk menganalisa perbandingan variabel-variabel yang mempengaruhi return on asset pada Bank Umum Syariah (BUS) dengan Unit Usaha Syariah (UUS). Adapun variable-variabel bebas yang digunakan pada penelitian ini adalah non performing financing, financing to deposit ratio dan porsi penyaluran pinjaman usaha mikro, kecil dan menengah (UMKM). Metode yang digunakan adalah kuantitatif dengan pendekatan regresi berganda dalam melakukan analisa penelitian ini. Hasil dari penelitian ini diketahui bahwa NPF BUS berdampak negatif dan signifikan terhadap  ROA BUS; FDR BUS berdampak postif dan tidak signifikan terhadap ROA BUS; porsi penyaluran pinjaman UMKM BUS berdampak negatif dan tidak signifikan terhadap ROA BUS; NPF UUS berdampak negatif dan signifikan terhadap ROA UUS; FDR UUS berdampak positif dan signifikan terhadap ROA UUS; Porsi penyaluran pinjaman UMKM UUS berdampak positif dan signifikan terhadap ROA UUS.Kata kunci: BUS, UUS, ROA, NPF, FDR, Pembiayaan UMKM
Pareceres
Authors: Duarte Clenício da Silva
Published: May 2021

Biblioteca Nacional — reorganização decorrente do Decreto-lei n. 8.679, de 1946. Não é defeso ao poder regulamentar ampliar a organização interna de órgãos públicos, ainda que essa organização provenha de ato legislativo. Estando a matéria contida na competência regulamentar, esta tem a sua atuação livre, não interferindo no caso a competência anterior. A alteração do direito positivo vigente. com absorção da competência então legislativa pelo poder regulamentar, tem como consequência a plenitude do seu exercício.
Магнитный аналог вращения Квинке
Authors: Грачев А.И.
Published: May 2021

Opportunity to observe magnetic analog of the Quincke rotation effect, namely, spontaneous rotation of a spherical particle in homogeneous DC magnetic field (B), is analyzed. Two experimental versions: nonmagnetic particle suspensioned in ferromagnetic liquid and, second, - diamagnetic sphere levitated in vacuum, are considered. In the first case spontaneous rotation is possible in the fields B < 0.1 T for relaxation times of the particle magnetization ~ 10-3 s. Indispensible condition of accelerated spinning of the diamagnetic sphere is confinement of its rotation degree of freedom by only one rotation axis orthogonal to the vector B.
Энергопотребление при высокочастотной модуляции неохлаждаемого InGaAs/GaAs/AlGaAs-микродискового лазера
Authors: Жуков А.Е. , Моисеев Э.И. , Надточий А.М. , Драгунова А.C. , Крыжановская Н.В. , Кулагина М.М. , Минтаиров С.А. , Калюжный Н.А. , Зубов Ф.И. , Максимов М.В.
Published: May 2021

The energy consumption of a microdisk laser with InGaAs/GaAs quantum well-dots operating uncooled under high-frequency modulation was investigated. For a microlaser with a diameter of 20 μm, the lowest power consumption of 1.6 pJ was obtained per one bit of data transmitted using an optical signal.
Резонансный отклик масштабно-инвариантных функций случайного процесса с турбулентным спектром
Authors: Коверда В.П. , Скоков В.Н.
Published: May 2021

Scale-invariant random processes with large fluctuations are modeled by a system of two stochastic nonlinear differential equations describing interacting phase transitions. It is shown that under the action of white noise, a critical state arises, characterized by a turbulent spectrum and a scale-invariant distribution function. The critical state corresponds to the maximum entropy, which indicates the stability of the process. An external harmonic action on a random process with a turbulent spectrum gives rise to a resonant response of scale-invariant functions.
Численное моделирование вольт-амперной характеристики биполярного мемристора на основе оксида гафния
Authors: Алёшин А.Н. , Зенченко Н.В. , Рубан О.А.
Published: May 2021

A finite element model has been developed that allows calculating the current-voltage characteristic of a bipolar memristor based on hafnium oxide Pt/HfO2/TiN, which reflects both the high-resistance and low-resistance states of the memristor. The mathematical basis of the model was Maxwell's equations for the stationary case. The model allows us to evaluate the relationship between the properties of materials included in the structure of the memristor and its operating current.
Электронный спектр капсулированных монослоев: аналитические результаты
Authors: Давыдов С.Ю.
Published: May 2021

Green’s function method is used to find the dispersion low for a monolayer (ML) placed be-tween two crystalline slabs. Weak- and strong-coupling regimes are considered in details. For the systems graphene, hBN – metallic ML – SiC polytypes analytical expressions for the ML electron effective masses are obtained. It is shown that the effective mass decreases with the increase of the SiC polytype energy gap.
The Impact of Inpatient Telemedicine on Personal Protective Equipment Savings During the COVID-19 Pandemic: Cross-sectional Study
Authors: Halabi Reem , Smith Geoffrey , Sylwestrzak Marc , Clay Brian , Longhurst Christopher A , Lander Lina
Published: May 2021

With the emergence of the COVID-19 pandemic and shortage of adequate personal protective equipment (PPE), hospitals implemented inpatient telemedicine measures to ensure operational readiness and a safe working environment for clinicians. The utility and sustainability of inpatient telemedicine initiatives need to be evaluated as the number of COVID-19 inpatients is expected to continue declining. In this viewpoint, we describe the use of a rapidly deployed inpatient telemedicine workflow at a large academic medical center and discuss the potential impact on PPE savings. In early 2020, videoconferencing software was installed on patient bedside iPads at two academic medical center teaching hospitals. An internal website allowed providers to initiate video calls with patients in any patient room with an activated iPad, including both COVID-19 and non–COVID-19 patients. Patients were encouraged to use telemedicine technology to connect with loved ones via native apps or videoconferencing software. We evaluated the use of telemedicine technology on patients’ bedside iPads by monitoring traffic to the internal website. Between May 2020 and March 2021, there were a total of 1240 active users of the Video Visits website (mean 112.7, SD 49.0 connection events per month). Of these, 133 (10.7%) connections were made. Patients initiated 63 (47.4%) video calls with family or friends and sent 37 (27.8%) emails with videoconference connection instructions. Providers initiated a total of 33 (24.8%) video calls with the majority of calls initiated in August (n=22, 67%). There was a low level of adoption of inpatient telemedicine capability by providers and patients. With sufficient availability of PPE, inpatient providers did not find a frequent need to use the bedside telemedicine technology, despite a high census of patients with COVID-19. Compared to providers, patients used videoconferencing capabilities more frequently in September and October 2020. We did not find savings of PPE associated with the use of inpatient telemedicine.
NOVEL FINDINGS OF PHOENIX DACTYLIFERA, DATES FRUIT EARLY-STAGE HABABUK FOR PHYTOCHEMICAL SCREENING, ANTIOXIDANT AND CYTOTOXIC POTENTIALS
Authors: AHAMMED SHAKKEELA YUSUF ERATTIL , ALMUTAIRI AREEJ MUHAMMED , AL-RASHIDI FATIMA SULIMAN , ALMUTAIRI OHOUD FAHAD
Published: May 2021

Objective: The present study aims to investigate the phytochemical constituents, antioxidant, and cytotoxic activity of the total ethanolic extract of the hababuk stage of date’s fruits Phoenix dactylifera (PDHE).

Methods: Extracts PDHE obtained with shade dried and a powdered sample of hababuk stage of date fruits Phoenix dactylifera and subjected to phytochemical screening, in vitro antioxidant activity study by DPPH assay and ABTS assay, in vitro cytotoxic studies carried out for three different cell lines Lung Cancer (A549), Human cervical carcinoma (HeLa) and Breast Cancer (MCF)-7 cells by MTT method and brine shrimp lethality assay using standard procedure.

Results: The phytochemical study revealed the presence of important constituents like alkaloids, glycosides, phenolic, flavonoids, carbohydrate, proteins, amino acids, terpenoids, steroids, and saponins. The antioxidant studies of the PDHE compared with standard showed very excellent results IC50 values for DPPH activity and nitric oxide. A good result was also shown by ABTS when compared with that of standard. The brine shrimp lethality assay is considered a useful tool for preliminary assessment of toxicity. The extract showed excellent LC50 value, which correlates with cytotoxicity studies previously established. The MTT study results using the three different cell lines compared with the standard doxorubicin, promising results obtained for HeLa cell lines when compared with other cell lines.

Conclusion: Results obtained from the present work indicated that the hebabuk stage of date fruit is a promoising antioxidant and anticancer agent. Further study should be carried out to isolate the bioactive compound responsible for the activity.
ETHNOPHARMACOLOGICAL STUDY OF BRAIN OXIDATIVE STRESS IMPROVING POTENTIAL OF CURCUMIN IN INTOXICATED RATS
Authors: EL-SAYED FATEN IBRAHIM
Published: May 2021

Objective: The following study aimed to investigate the efficacy of curcumin at preventing amikacin neurotoxicity

Methods: Twenty-four male Wister albino rats were randomly divided into four groups including-G (1): control group includes six rats, they were administered 0.5 ml of saline orally for 14 consecutive days. G (2): includes six rats; they were administered 200 mg/kg curcumin orally for 14 consecutive days. G (3): includes six rats, they were administered 300 mg/kg body weight/day of amikacin intraperitoneally for 14 consecutive days G (4): includes six rats, they were administered 200 mg/kg curcumin orally concurrently with 300 mg/kg body weight/day of amikacin. All animals were kept in the same conditions from feed, heat and humidity.

Results: According to the result obtained after sacrification of all animals after the end of 14 d, Results revealed that amikacin at the dose rate of 300 mg/kg b. wt for 14 d induces significant changes in oxidative stress markers compared to the control group, a significant reduction in CAT. SOD. GSH (1.51±0.16, 77.00±0.73 and 84.06±4.42) respectively compared to control (3.63±0.11, 98.48±0.18 and 117.05±0.52) along with a significant increase in MDA activity (219.02±3.34) compared to control group (180.42±0.19), That indicate oxidative stress effect of it. On the beneficial side rats received amikacin 300 mg/kg B. wt I/p concurrently with 200 mg/kg b. wt curcumin for successive 14day result in a significant increase in CAT. SOD. GSH (2.23±0.09,92.00±0.26, 102.25±1.71) and decrease in MDA concentration (139.23±3.89) compared to amikacin treated group levels along with histopathological changes appear in brain tissue in the group treated with amikacin include nuclear pyknosis and degeneration in some neurons in the hippocampus, multiple focal eosinophilic plaque formation in the striatum also this results enhanced by activated caspase-3 expression in the brain tissue following amikacin administration.

Conclusion: The present study proved that Oral administration of curcumin at the dose of 200 mg/kg for 14 d concurrently with amikacin significantly mitigates its neurotoxic and oxidative stress effects.
Passive nihilism and ontotheology: A reply to Husbands on derivative temporality
Authors: Smidt Austin Hayden
Published: May 2021

Conor Husbands’ defense and expansion of Elena Esposito's temporality of finance is a much-needed intervention. However, in this response essay, I will show a few of the fundamental weaknesses of Esposito's project, and by extension will highlight some shortcomings of Husbands’ defense-expansion. The point is not to dismiss either project; the goal is rather to bring attention to certain philosophical presuppositions that ground both, and that enclose each in what Markus Gabriel would call an ontotheological orientation. In short, Esposito and Husbands operate via an orientation that attempts to think ‘the world’ as an all-encompassing domain, despite claims to the contrary. How this occurs will be explained below, paying particular attention to the stakes of thinking from such an ontotheological orientation in and to the world. After first presenting Husbands’ argument, I develop some critiques of Esposito and Husbands via the work of Suhail Malik, Ray Brassier, Elie Ayache, Jon Roffe, and Quentin Meillassoux. I then open the aperture towards emerging trends in philosophy that contest the foundations upon which Esposito's project is built, in order to suggest more robust readings of finance and society. The work of Sergei Prozorov and Markus Gabriel will be the focus here, but these thinkers merely serve as stand-ins for larger trends in speculative- and neo-realism.
A manufacturability-based assessment and design modification support tool
Authors: Abdelall Esraa S. , Alawneh Luay , Eldakroury Mohamed
Published: May 2021

In the light of momentous technological development and market competitiveness, designers struggle to generate creative and successful designs to survive in the market and stay competitive. However, being in such a stressful work environment, any slip, or flaws during the design stages, particularly those related to manufacturing, can make design more vulnerable to fail. Therefore, the designer is in need of aiding means to guarantee minimizing and controlling these costly errors. Thus, this paper presents a new tool, called DesMod, to help the novice designers as well as the design students avoid such issues, as well as to save time, effort and cost. Through DesMod, the designer can assess the manufacturability of the design and receive design modification suggestions and feedback at early design stages. This can be achieved by simply importing 3D CAD models in STEP or IGES format within DesMod. Next, the design features can be recognized in a hybrid way, either automatically and/ or manually; then mapped to the corresponding database in the background. Any additional manufacturing-related information such as materials, surface quality, production volume, among others, can be also entered. Once information about the design is entered and mapped, the manufacturability assessment and the associated design modification suggestions can be generated and stored in PDF format. In this paper, the casting module of DesMod was tested with many designs ranging from simple to complex, and acceptable results were obtained.
Determination of natural modes of railway overpasses
Authors: Abdullayev Seidulla S. , Bakyt Gabit B. , Aikumbekov Muslim N. , Bondar Ivan S. , Auyesbayev Yerlan T.
Published: May 2021

Currently, there are many software systems and environments that allow you to simulate and perform fairly complex and voluminous calculations associated with dynamic effects on structural elements of overpasses. The aim of the article is to make an analysis of a reinforced concrete railway overpass as a whole and its elements separately. The article presents the calculated and experimental data of the forms and frequencies of natural vibrations of reinforced concrete railway overpasses under constant loads and the rolling stock off the span. As a result of the analysis of the tests, it was determined that the effect of the rolling stock passing through the reinforced concrete beam spans of 16.5 m and 23.6 m appears with frequency perturbations that are in the range f = 4.41 ÷ 9.52 Hz. These studies can be further used in the design of artificial structures, as well as to identify defects in structural elements of railway bridges.
Characteristics of calcined palm oil pastes for biosilica extraction as a function of calcination temperatures
Authors: Samat N. A. S. Abdul , Jaman U. Z. Kamarul , Saree S. , Mahmod D. S. A. , Lai J. C. H.
Published: May 2021

Palm oil production in Malaysia has increased over the years. As the consequence of high production of palm oil, surplus quantities of palm oil biomass wastes such as empty fruit bunches (EFB), palm kernel shell (PKS), and oil palm decanter cake (DC) are generated. Generally, these wastes are used as fuel to generate steam for boilers, which end up as ash. As several agricultural wastes are well-known to be rich in silica content, this study aims to investigate the bio-silica content of EFB, PKS and DC and their characteristics when calcined at various calcination temperatures from 400°C to 800°C. Several analyses were conducted such as weight loss, color, BET, SEM and FTIR. The results have shown that all samples favorably exhibited silica at higher temperatures, i.e., 800°C. Color analysis depicted that combustible elements were mostly removed at 800°C, leaving non-combusted silica in the waste ash. Weight loss analysis presented that EFB achieved the highest weight loss at 99.05%, followed by PKS at 95.65% and DC at 83.95%. This led to a relatively high amount or purity of silica in the sample. BET analysis showed highest surface area, 20.087m2/g (PKS) and the lowest is 9.492m2/g (DC) at 800°C which verified the high porosity of samples for further absorption applications. The presence of silica was also significantly observed in 800°C FTIR spectra for all waste samples. Overall, it is concluded that EFB, PKS, and DC are highly potential wastes to contribute to the production of bio-silica, which thus can be an option to overcome waste disposal issues in palm oil industries.
Response of the magnetosphere to perturbation by storms and Alfvén wave trains
Authors: De la Vega Matías , Favetto Alicia B.
Published: May 2021

El comportamiento de la magnetosfera como un sistema dinámico ha sido estudiado a través del análisis de distintos índices de la actividad geomagnética. Sin embargo aun no se llegó a ninguna respuesta definitiva a este problema. Los estudios iniciales de reconstrucción del espacio de fases a partir de las series temporales del índice AE sugirieron la presencia de un atractor de baja dimensión; estudios posteriores no confirmaron este resultado. El problema radica en que la fuente de excitación de la magnetosfera, el viento solar, es turbulento y por lo tanto es incorrecto considerar a este sistema como autónomo. En el presente trabajo, estudiamos la serie temporal del índice AE con muestreo cada minuto en tres condiciones físicas distintas. Se compara una tormenta geomagnética (intervalo de tiempo durante el cual el índice Dst tiene valores menores de -100 nT), valores de Dst mayores de -20 nT, (actividad geomagnética débil), y actividad auroral continua de alta intensidad y larga duración (evento HILDCAA). El estimador de Takens de la dimensión de correlación se determinó para estas condiciones y un conjunto de datos "surrogated"; los resultados no indicaron concluyentemente un carácter determinista. A continuación se estudió la predictibilidad de las series y sus "surrogated". Se halló que el caso correspondiente al evento HILDCAA es el más predictible y consecuentemente de menor dimensión de correlación. Concluimos que, frente a un evento HILDCAA, la magnetosfera actúa como un sistema excitado en forma estacionaria.
A general overview of the catalog of recent seismicity compiled by the Mexican Seismological Survey
Authors: Zúñiga F. Ramón , Reyes Marco A. , Valdés Carlos
Published: May 2021

Hemos analizado el catálogo de sismicidad reciente de México del Servicio Sismológico Nacional, el cual está basado en compilaciones automáticas de los reportes de sismicidad. Para ello, empleamos diversas técnicas desarrolladas con el propósito de investigar los índices de sismicidad y sus características. En nuestro análisis encontramos que la tendencia de los reportes en el tiempo sufrió un cambio drástico durante 1988. Antes de esa fecha, los procedimientos de rutina comprendían la localización de un gran número de eventos, pero sin asignarle magnitud a los más pequeños. Esta situación cambió en 1988 ya que se detecta una reducción en el número de eventos pequeños localizados aunado a un aumento significativo en el número de eventos a los que se determinó su magnitud. La magnitud mínima para la cual es completo el catálogo en el período 1988-1998 fue determinada como = 4.3. Una comparación de las distribuciones frecuencia-magnitud entre (determinadas por PDE) y (SSN) apoyan la hipótesis que ambas magnitudes son básicamente equivalentes en el rango Mâ‰¤5.0. Estos resultados son importantes ya que demuestran lo serio que podrían ser los errores al usar los datos sin consideración de los períodos y cambios en el reporte. Por otro lado, nuestros resultados proporcionan la forma de corregir por inhomogeneidades del catálogo, de manera que los datos puedan ser usados en estudios estadísticos. Con relación a los cambios espacio-temporales más significativos con un posible origen natural se encontraron varios casos que se requiere estudiar individualmente.
Near shore submarine hydrothermal activity in Bahia Banderas, western Mexico
Authors: Núñez Cornú F. J. , Prol Ledesma R. M. , Cupul Magaña A. , Suárez Placencia C.
Published: May 2021

Recientemente se descubrió la existencia de actividad hidrotermal en la zona de Bahía de Banderas. Las implicaciones de esta actividad en el esquema tectónico de la parte central de México apoya la hipótesis de que está ocurriendo actividad tectónica reciente en esta área. Se detectaron tremores en estaciones sismológicas portátiles que fueron instaladas en los alrededores. Se analizaron muestras de las chimeneas formadas por la actividad hidrotermal y se encontró una secuencia de depositación dominada por carbonatos en la primera etapa (calcita y dolomita), seguida por apatita y vetas tardías de barita. También se presentan capas de depositación secuencial de sulfuros y fosfatos que pueden interpretarse como resultado de las variaciones en la fugacidad del azufre.