bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengembangan media prezi untuk pemahaman nilai-nilai Pancasila Sila ke-2 pada pembelajaran tematik muatan PPKn kelas III SD Negeri Baran Bantul Yogyakarta
Authors: Handayani Diva Ayu , Pratomo Wachid , Nadziroh
Published: December 2023

This study aims to 1) determine the development of Prezi learning media in thematic learning PPKn content in order to increase students' understanding of the values of the second Pancasila precept, 2) determine the feasibility test of Prezi learning media in thematic learning PPKn content in order to increase students' understanding of the values of the second Pancasila precept with the subject matter of practicing the second Pancasila precept (respecting the diversity of characteristics). This type of research uses the Research and Development method which refers to the 4D development procedure consisting of 4 stages, namely define, design, develop, and disseminate. Data collection techniques used at the define stage are observation and interviews and at the develop stage are validation sheets. The data analysis technique used is descriptive statistical analysis. The results of this study indicate that the Development of Prezi Media for Understanding the Values of the 2nd Pancasila Precepts in Class III PPKn Content Thematic Learning at SD Negeri Baran Yogyakarta, the subject matter of implementing the second precept of Pancasila (respecting the diversity of characteristics) obtains media feasibility results with a tendency for the product to be at good category. This can be seen from the validation results of media experts showing that the criteria are: Very Good (60%), Good (40%), Poor (0%), and Enough (0%). Then, the feasibility of the material contained in the developed Prezi learning media is: Very Good (61%), Good (39%), Less (0%), and Enough (0%). From the criteria that have been obtained, it can be concluded that Prezi media is appropriate for use in thematic learning of PPKn content with the subject of respecting the diversity of characteristics.
Upaya meningkatkan hasil belajar IPS melalui strategi peer lessons pada Siswa Kelas IV di SDN 2 Kalangsari
Authors: Kirana Mochammad Delfianova , Darusman Yus , Pratama Febri Fajar
Published: December 2023

Based on initial observations showing low student learning outcomes, classroom action research was conducted on class IV students at SDN 2 Kalangsari. The average score on student test results in social studies learning is still below the minimum completeness criteria (KKM) set by the school, namely 75. In the 2022–2023 school year, the aim of this research is to improve social studies learning. learning outcomes of class IV students at SD Negeri 2 Kalangsari, Tasikmalaya City by implementing the Peer Lessons learning strategy. Classroom action research is this type of research. The research subjects were 12 male and 6 female students in class IV of SD Negeri 2 Kalangsari, Tasikmalaya City in the even semester of the 2022–2023 academic year. This research was carried out in 2 cycles, with 2 meetings in each cycle. Tests and observations are the methods used in data collection. As many as 75% of students who took part in the learning process met the Minimum Completeness Criteria (KKM), namely 75. This increase in social studies learning outcomes is a sign of research success. Research findings show that implementing peer lessons learning strategies improves social studies learning outcomes. After the first cycle of action, 7 students (38.89%) did not complete, while 11 students (61.11%) achieved completion. After cycle II activities, there were 3 students (16.67%) and 15 students (83.33%) who had not completed their studies. Based on the research findings, it can be said that the researcher has a clear understanding of the classroom environment. Therefore, researchers and class teachers work together to develop action plans that can improve social studies learning outcomes for class IV students.
International humanitarian law and the international legal status of journalists
Authors: Lisenco Vladlena
Published: December 2023

This article analyses international instruments in the sphere of international humanitarian law, in particular, devoted to ensuring the protection of journalists during an armed conflict. The absence of clear legal criteria of non-international conflict, incomplete guarantees of rights of mass media employees may give grounds for manipulation or ignoring their legal protection. The author gives the concept of the system of protection of rights and freedoms of journalists covering military conflicts, legal status during an armed conflict, conclusions and proposals to fill the gaps in international humanitarian law.
The principle of interdependence of judges in the light of the findings of the European Court of Human Rights in the case of Oleksandr Volkov vs. Ukraine
Authors: Capatina Carolina
Published: December 2023

The independence of justice is a fundamental principle that lies at the heart of any fair and functioning legal system. It serves as a cornerstone of democracy and the rule of law, ensuring that justice is dispensed impartially, without undue influence or bias. At its core, the independence of justice refers to the separation of the judiciary from external pressures, be they political, economic, or societal. In a society governed by an independent judicial system, judges are free from interference, allowing them to make decisions based solely on the law and the merits of each case. This autonomy not only safeguards the rights and liberties of individuals but also fosters public trust in the legal process. Throughout history, the struggle for judicial independence has been a continuous endeavor, shaped by legal reforms, constitutional provisions, and international agreements. Yet, challenges persist, and the pursuit of a fully independent judiciary remains a vital objective for societies worldwide. The controversial case of Oleksandr Volkov v. Ukraine, revealed a central problem of the entire human rights protection system –the independence of the judiciary, and later served as a reason for a considerable change, reforming the justice system in the country, as well as an example for others.
Influence of Roman religion on Christianity
Authors: Byelov Dmitro
Published: December 2023

This article traces the influence of traditional Roman religion on Christianity. The establishment of the most important dogmas and the formation of the church hierarchy are analyzed. The classical era is the Christian period of history that initiated the most important dogmas and formed the church hierarchy. The practice of Ecumenical Councils, which became the main governing bodies of the church, was introduced. The first Ecumenical Council was held in Nicaea. It approved the Creed, which was an exposition of the main dogmas that were obligatory for Christians. The Council of Nicaea was held for two months from June 19, 325. Taking into account historical sources, about three hundred and fifty bishops participated in it. It featured a speech by Emperor Constantine, in which he emphasized the importance of unity and harmony. The emperor needed a single and strong religion that would strengthen his rule.
Pengaruh Kompetensi, Komitmen Organisasi dan Budaya Organisasi Terhadap Organizational Citizenship Behavior
Authors: Yudistira Cokorde Gede Putra , Supiatni Ni Nyoman , Muderana I Ketut , Putri I Gusti Ayu Agung Utami Cahaya
Published: December 2023

The purpose of this study was to determine the partial and simultaneous influence and the level of competence, organizational commitment and organizational culture on Organizational Citizenship Behavior at PT. Angkasa Pura I (Persero) Ngurah Rai International Airport, Bali. This research is quantitative. Sources of data in this study using primary data and secondary data. Primary data in the form of data obtained through distributing questionnaires to 234 respondents as research samples and secondary data in the form of company general description data. The statistical analysis used in this study is multiple linear regression. The result of this research is that competence has a significant positive effect on Organizational Citizenship Behavior. This shows that the better the competence in the company, the higher the OCB felt by employees. Organizational Commitment has no significant effect on OCB. This shows that the good or bad organizational commitment of employees in the company will not affect the increase or decrease in the OCB of employees at PT. Angkasa Pura I (Persero) Ngurah Rai International Airport, Bali. Organizational culture has a significant positive effect on OCB. This shows that the better the organizational culture in the company, the higher the OCB felt by employees.
Analisis Implementasi Kearsipan pada Kantor Desa Peguyangan Kangin
Authors: Pahlevy Marsya , Menuh Ni Nyoman , Wimpascima Ida Bagus Ngurah
Published: December 2023

The Peguyangan Kangin Village Office is one of the agencies that manages the operational activities of the village government. Administrative activities of the village office require archive management. The research objective was to find out how the analysis of the implementation of filings at the Peguyangan Kangin Village Office. Data collection techniques include: interviews with heads and staff of administrative and general affairs. Observation by making direct observations in the field to find out the actual conditions regarding the archives at the Peguyangan Kangin Village Office. The data analysis technique used is descriptive qualitative. The results of the research are that the creation of archives has been carried out well. Archives are stored in a special shelf so that they are easy to find, no special standards are applied. The obstacle is the lack of storage space in the village archive warehouse. The advice that can be given is to destroy archives for archives that have not been used for 5-6 years so that old archives do not accumulate in the village archive warehouse. For the destruction of archives, confirmation should be made at the Denpasar City Archives and Libraries Service regarding the archive destruction policy. The village office should digitize in managing archives so that archives stored can be easily searched.
The legacy of the Altai composer Afanasy Stepanovich Anokhin as a focus of the formation of the national choral culture of the mid-twentieth century
Authors: Nikitina Tatiana Aleksandrovna , Zhernosenko Irina Aleksandrovna
Published: December 2023

The authors of the article consider the main directions of the development of choral culture of the twentieth century in the context of domestic and regional socio-cultural processes through the prism of the legacy of the multifaceted creative personality of A. S. Anokhin, as well as through the analysis of the biography and creative path of the composer, based on his diaries and memoirs; presenting his views on the historical events of that time from the point of view of the musician and a teacher. The figure of Afanasy Stepanovich Anokhin is one of the key figures in the musical education and enlightenment of the Altai Territory in the XX century, about his creative and educational activities. The novelty of the research lies in the reconstruction of the integral creative image of the composer in the context of the formation of musical culture in the Soviet period in the Altai Territory. In this work, for the first time, a complete list of the composer's published works is published. A. S. Anokhin's main compositional legacy is connected with mass songwriting, one of the most popular genres of the Soviet era. The article also examines the development of musical and choral culture in the Altai Territory from amateur groups to professional performance and the development of musical education throughout the twentieth century, as well as raises issues of preservation and reclamation of regional cultural heritage.
A secure solution based on load-balancing algorithms between regions in the cloud environment
Authors: Eljack Sarah , Jemmali Mahdi , Denden Mohsen , Turki Sadok , Khedr Wael M. , Algashami Abdullah M. , ALsadig Mutasim
Published: December 2023

The problem treated in this article is the storage of sensitive data in the cloud environment and how to choose regions and zones to minimize the number of transfer file events. Handling sensitive data in the global internet network many times can increase risks and minimize security levels. Our work consists of scheduling several files on the different regions based on the security and load balancing parameters in the cloud. Each file is characterized by its size. If data is misplaced from the start it will require a transfer from one region to another and sometimes from one area to another. The objective is to find a schedule that assigns these files to the appropriate region ensuring the load balancing executed in each region to guarantee the minimum number of migrations. This problem is NP-hard. A novel model regarding the regional security and load balancing of files in the cloud environment is proposed in this article. This model is based on the component called “Scheduler” which utilizes the proposed algorithms to solve the problem. This model is a secure solution to guarantee an efficient dispersion of the stored files to avoid the most storage in one region. Consequently, damage to this region does not cause a loss of big data. In addition, a novel method called the “Grouping method” is proposed. Several variants of the application of this method are utilized to propose novel algorithms for solving the studied problem. Initially, seven algorithms are proposed in this article. The experimental results show that there is no dominance between these algorithms. Therefore, three combinations of these seven algorithms generate three other algorithms with better results. Based on the dominance rule, only six algorithms are selected to discuss the performance of the proposed algorithms. Four classes of instances are generated to measure and test the performance of algorithms. In total, 1,360 instances are tested. Three metrics are used to assess the algorithms and make a comparison between them. The experimental results show that the best algorithm is the “Best-value of four algorithms” in 86.5% of cases with an average gap of 0.021 and an average running time of 0.0018 s.
Comparison of instrument-assisted soft tissue mobilization and proprioceptive neuromuscular stretching on hamstring flexibility in patients with knee osteoarthritis
Authors: Anjum Narmeen , Sheikh Raheela Kanwal , Omer Aadil , Anwar Kinza , Khan Muhammad Manan Haider , Aftab Anam , Awan Waqar Ahmed
Published: December 2023

Background

The association between hamstring tightness and knee osteoarthritis (KOA) is significant because tight hamstrings can put more strain on the knee joint, reduce its range of motion, and cause compensatory movements that worsen the KOA.

Objective

To compare the effects of instrument-assisted soft tissue mobilization (IASTM) and proprioceptive neuromuscular (PNF) on hamstring flexibility in patients with KOA.

Methods

Data for the randomized controlled trial (NCT05110326) was collected from n = 60 participants randomly divided into group A received IASTM and group B received PNF stretching. In group A, the therapist made 30 strokes gentle strokes with the tool from the origin to the insertion while holding the plane at a 45-degree angle over the treatment area. In group B, PNF stretching was done with three repetitions and 10 seconds rest between each, after isometric contraction of the hamstring muscle using approximately 50% of their maximum strength, holding it for 8 seconds, and then releasing it. A 30-minute session was given to each patient three times per week and was given for 6 weeks. Outcome measures were the visual analog scale (VAS) for pain intensity, the active knee extension test (AKET) for hamstring flexibility, and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) for the health status of KOA patients.

Results

The study found a significant interaction (p < 0.001) between interventions and time across several measurements. After 6 weeks, both interventions resulted in significant improvements (p < 0.001) across all dependent variables, with group A (IASTM) showing more significant improvement in hamstring flexibility, pain reduction, and health status (p < 0.001) compared to group B (PNF).

Conclusions

Both the IASTM technique and PNF stretching resulted in increased hamstring flexibility, decreased pain, and enhanced general health. The IASTM technique, however, showed potential benefits over PNF stretching in terms of flexibility, pain relief, and public health enhancement. Physical therapists and manual therapists may prioritize the usage of the IASTM technique for patients who want to make significant changes in these areas.
Profits Analysis of the Sheep Breeding Business in Bulu Cina Village, Indonesia
Authors: Marisa Julia , Sitepu Sukma Aditya , Rianto Aditiya Amanda , Suhut Anwar
Published: December 2023

Aims: Analyze the profits of sheep breeders in Bulu Cina Village, Deli Serdang Regency, Indonesia.

Study Design:  Descriptive quantitative.

Place and Duration of Study: From September to November 2023, Bulu Cina Village will be situated in Deli Serdang Regency, Indonesia.

Methodology: This type of research is descriptive, researchers who describe the variable conditions obtained by sheep farming business actors. The material that were used in this research is related to the overall data and field studies obtained, namely in the form of production costs and income from sheep farming businesses so that the income of sheep farming business breeders can be calculated and obtained.

Results: Sheep farming in the research area is profitable for sheep farmers as it yields an average net income of IDR 29.519.791 per 6 month. The breeders of beef sheep receive an average net income of IDR 2.459.983 per month. This type of activity is a feasible business option with an Revenue Cost Ratio value of 4,27.

Conclusion: To increase income from sheep farming businesses, it is essential to use production factors efficiently.
Assessment of the Quality of Banking Services Perceived by Rural Customers
Authors: Kirtiraj  , Singh Surabhi
Published: December 2023

The role played by banks in the economy of a country is of great importance. Growth of banking industry is directly related to economic growth of the country. New technologies are being introduced to increase quality of banking services. Present study was conducted in Dantiwada taluka of Banaskantha district of Gujarat and aimed at assessing perceived service quality of banking services by rural customers. A representative sample of 300 rural customers was selected randomly from six villages. Personal and socio-economic characteristics were studied as independent variables, whereas, quality of banking services as dependent variables. An interview schedule was formed which comprised questions related to background information, personal and socio economic variables and type and extent of services utilized by rural customers along with a teacher made scale to measure the service quality of banking services perceived by rural customers. Data were collected by personal interview technique. Descriptive type statistical tools, correlation and ANOVA were used for data analysis and Cronbach’s alpha test was applied to check the reliability of scale. All the dimensions of scale were found highly reliable. Assurance dimensions of service quality was perceived at the highest rank with 45.20 score by customers followed empathy, security and responsiveness. The reliability dimension was perceived at the lowest rank with 29.28 score.
Bullying Behavior among Secondary School Students in Hai District, Kilimanjaro Region,Tanzania
Authors: Mboya Joyce J. , Alloph Justine Matiko
Published: December 2023

The study assessed the extent to which bullying behavior exists among secondary school students in Hai District, Moshi Region-Tanzania. Mixed approaches, and convergent parallel design were applied in this study. Data were collected using questionnaires, interviews. The study collected data from the sample of one hundred and seventy-one (171) persons selected from 13,945 target population. The SPSS software package was used to examine quantitative data while qualitative data was analyzed using thematic analysis. The findings of the study show that, bullying behaviour exists in Secondary schools at Hai district. The study concludes that, the rate of bullying acts such as hitting, beating, stealing, senior students oppressing junior students, gossiping and spread rumours about others, use of insulting words, bad name-calling and excessive punishment were practiced by students in schools. It has impact to students‟ academic achievement and the whole life in general. The study recommended that policy makers should encourage the practice of effective control of bullying in schools by formulating anti-bullying policies to guide effectiveness in bullying management.
Navigating the Digital Landscape: Challenges and Opportunities for Online Businesses in the Upper East Region of Ghana
Authors: Laar David Sanka , Kolog Peter Naambuliya , Agbedemnab Peter Awonnatemi , Bayitaa Strato Angsoteng
Published: December 2023

This paper delves into the transformative impact of technology on human activities, particularly the digitisation of major and basic tasks. The business landscape has not been immune to this revolution, with traditional methods giving way to digitalisation, commonly referred to as online or electronic business (e-business). Defined as any business activity conducted over the internet, e-business offers numerous benefits, such as global reach and geographical flexibility. However, it is not without its drawbacks, with online fraud undermining customer trust and infrastructure costs posing challenges. In the Upper East Region (UER) of Ghana, some entities have transitioned their operations entirely online, while others employ a click-and-mortar approach, operating both online and offline. This study employs a quantitative survey design, using an online questionnaire to investigate and understand the challenges and opportunities faced by online businesses in the UER. The research, based on a sample of fifty-two (52) businesses, identifies a lack of digital skills and high data costs as the primary challenges. Significantly, the study reveals untapped potential in the agricultural sector for online business in the UER. The findings not only outline these challenges and opportunities but also propose strategies to address the former and sustain the latter, offering valuable insights for businesses navigating the evolving digital landscape in the UER.
Review- Effects of Food Processing on Nutrients
Authors: Singh Bhavna , Pavithran Nanditha , Rajput Reshu
Published: December 2023

The processing of food is a common method that converts raw materials into edible items that are safer, simpler to prepare and frequently more appealing to customers this change however has implications for the nutritional composition of meals It is used to describe the effects of different processing methods on vitamins, minerals and macronutrients etc understanding these consequences is critical for establishing healthy eating habits and improving public health. By refrigerating, below freezing, fermenting, drying, and adding salt or sugar, pathogen development can be decreased or prevented, pathogens can also be killed by using heat treatments such as pasteurization, sterilization and frying because these precautions help to safeguard customers, the majority of food-borne disease incidents involve pathogen-contaminated raw animal products, fruits, and vegetables etc. Food processing's function has varied over time, High-intensity economically processed food frequently has more added sugar, salt and calories, in addition to a lower micronutrient density than comparable food or meals cooked at home from raw or lightly treated sources food processing entails a number of procedures that might have an influence in the quality of food, especially nutritious quality as well as food safety heating and spray drying are all examples of food processing operations these processes can affect the content and quality of fats, vitamins, carbohydrates and proteins etc.
Effect of COVID-19 on the Profitability of the Hospitality Industry
Authors: Rathore Veena , Sangma Salnamchi J. , Vidhya C.S.  , Hidangmayum Narmada , Naqvi Syed Rizwan , Lytand Wankasaki , Indira R. , Magrey Ashiq Hussain
Published: December 2023

By utilizing three firm-level factors (financial conditions, corporate strategy, and ownership structure), the current study investigates how the impact of COVID-19 on Indian hospitality sectors' stock returns differs depending on the firms' pre-pandemic characteristics. The results of this study, which used 795 firm-year observations from annual reports and other databases, show that restaurant businesses with past traits of greater size, greater leverage, greater cash flows, lesser ROA, and greater internationalization are more resilient to stock declines in response to COVID-19 than other businesses of a similar nature. Conversely, there was no discernible moderating influence of dividends, franchising, institutional ownership, or managerial ownership on the association between COVID-19 and stock returns. By offering insights into the factors that affected India's industrial stock returns during the COVID-19 shock, this paper illuminates its research issue. The factors and methodology utilized in the current study can be applied in subsequent studies to deepen our understanding of the problem. One of the segments of the economy that is most adversely affected by COVID-19. The ability to contain the pandemic and the macroeconomic effectiveness of the policies implemented by public institutions to promote overall economic recovery are both essential to its recovery. In this context, industry stakeholders must evaluate both the potential influence of economic policies on the hotel sector as well as the direct economic impact of the COVID-19 pandemic's evolution. The COVID-19 pandemic is thought to have had a particularly large impact on the hotel sector, and the uncertainty around how long the pandemic will last makes it difficult to predict how quickly things will turn around. In this regard, the goal of this exploratory study is to give insight into how prepared the hospitality industry is for COVID-19 risk, as motivated by their persistence and financial slack holdings. The empirical results support the notion that their risk readiness should be rated as having a low degree of financial slack. Most of the analyzed hospitality industry had little or no financial slack, and they had recently used up their financial slack resources. As a result, it is uncertain if the hospitality industry would be able to withstand the financial issues that resulted from the COVID-19 epidemic. We come to conclusions on the required system intervention design in light of this evidence that could help the hospitality industry avoid bankruptcy.
Arthospira platensis and Bacillus subtilis Synergies for Sustainable Agriculture
Authors: Meena S.  , Manimekalan A.  , Kavitha Pushpam A.
Published: December 2023

The aim of this study is to analyze the biofertilizer value of B. subtilis by estimating its phosphate solubilizing potential and its antagonistic activity against pathogenic strains of E. coli and Bacillus cereus. Prolonged use of chemical fertilizers have adverse effects on the soil and through food chain they cause hazards to organisms including humans. Moreover pests and pathogenic microbes are becoming immune to the chemical pesticides and herbicides. Hence the need of biofertilizers that are ecofriendly and good biocontrol agents are gaining importance. Use of biofertilizers leads us towards the path of sustainable agriculture yielding better productivity without compromising the fertility of agricultural fields. Bacillus subtilis is a PGPR (Plant growth promoting rhizobacteria) capable of phosphate and zinc solubilizing and it increases the bioavailability of nutrients to the plants. Due to its antagonistic nature, B. subtilis can be utilized in biocontrol management practices. Arthospira platensis is a well explored microalgal species that is rich in micronutrients and a wide array of amino acids that has immense biofertilizer value. The methodology involves UV spectrometric estimation of bioavailable phosphate in Pikovskaya’s broth at 690nm and percentage of inhibition of B. subtilis against E. coli and Bacillus cereus using OD600values. Evidences for utilizing mixed culture of A. platensis and B. subtilis as biofertilizer are explored from literature. B. subtilis strain AMLA5 isolated from oil contaminated soil from Coimbatore had phosphate solubilizing potential of 1.3ppm and showed good antagonistic effects against E. coli and B. cereus. The NCBI genebank accession number of the strain SUB13179211 AMLA5 is OQ874086 that showed 99.77% sequence identical to Bacillus subtilis. This strain was a surfactin producer that utilized A. platensis as its economical substrate. A. platensis & B. subtilis are GRAS level organisms that can be utilized in agriculture as biofertilizer as mixed culture. The synergism existing between these two organisms can be exploited in multiple sectors
Non-Synonymous Mutations Associated with Plasmodium falciparum Artemisinin Resistant Gene (Pfkelch13) in Malaria Cases, Jos Nigeria
Authors: Paul Joel , Nwankwo Nelson J. , Simon Mercy O. , Gaknung Shangshikmwa K. , Fakdul Timloh , Davou Dinci T. , Mankilik Mary M. , Kutshik Richard J. , Yakubu Bitrus , Longdet Ishaya Y.
Published: December 2023

Aim: The aim of this study was to explore the Plasmodium falciparum Artemisinin Resistant Gene (Pfkelch13) in malaria cases in Jos and profile the nature of the mutations. The Plasmodium falciparum kelch13 gene is a potential molecular marker for tracking artemisinin-resistant malaria parasites.
Study Design: The Study Design was Experimental
Place and Duration of Study: The study was conducted within Jos, Nigeria between October 2019 and January 2021.
Methodology: Thirty-six clinically screened 2 plus (++) and above positive malarial whole blood samples were collected from a Hospital in Jos, Plateau State, Nigeria in EDTA bottles after being granted ethical approval. The DNA extraction was done using Zymo Research extraction kits according to the manufacturer’s instructions. Detection of the Plasmodium genus, Plasmodium falciparum and Pfkelch13 gene in the samples was done using PCR technique and gel electrophoresis. PCR amplicons were sequenced and bioinformatics software was used to analyze the sequences for mutations. 
Results: Only 41.67% of the samples collected were confirmed positive for the Plasmodium genus. Out of these, 93.33% were positive for Plasmodium falciparum. The PfKelch13 (Pfk13) gene was detected in 78.57% of the Plasmodium falciparum. Non-synonymous mutations (S695C, C696M, C696H, H697S, H697V, F698I, 699L and 699S were observed at the amino acids level, but didn’t affect the structural conformation of the proteins.
Conclusion:  The classical method of detecting malaria is not reliable compared to the PCR technique. Non-synonymous mutations on the PfKelch13 gene have the potential to cause resistance to artemisinin drugs in the Jos human population.
Comparative Evaluation of the Anti-Inflammatory Properties of Methanol and Aqueous Crude Extracts of Apical leaves of Sida cuneifolia: An Ethnomedicinal Plant
Authors: Kambugu Ivan , Abdelgadir Abdelgadir Alamin , Sesaazi Duncan Crispin
Published: December 2023

Aims: This study aimed to assess and compare the yield, phytochemical compositions, and anti-inflammatory properties of methanol and aqueous crude extracts derived from the Apical leaves of Sida cuneifolia.
Study Design: An analytical study design was employed to evaluate yield and phytochemical composition, while an experimental study design was utilized for anti-inflammatory evaluation studies.
Place and Duration of Study: The study was conducted at Mbarara University of Science and Technology, specifically in the Department of Pharmacy Laboratory, spanning from August 2022 to September 2023.
Methodology: The extraction yields were determined, and phytochemical profiling conducted to establish the composition of the extracts. Acute dermal toxicity was assessed to determine s. cuneifolia ointment toxicity level using OECD guidelines No. 402. Anti-inflammatory activities were evaluated using the HRBC membrane stabilization model and carrageenan-induced paw inflammatory model in-vitro and in-vivo, respectively.
Results: The aqueous extract exhibited a higher percentage yield (10.1%) compared to the methanol extract (4.7%). The methanol extract contained alkaloids, phenolic compounds, steroids, tannins, and cardiac glycosides, while alkaloids and cardiac glycosides were absent in the aqueous extract.
Methanol and aqueous extracts, at different concentrations of (0.5, 1.0, 2.0 mg/mL), showed dose-dependent significant stabilization towards HRBC membranes of (54.6%, 59.9%, 66.5%), and (3.85%, 12.57%, 17.10%), respectively. The percentage of protection for the concentration of the methanol extract at 2.0 mg/mL was the highest (66.5%) among the extract dose levels but lower than that of the standard (76.66%).
Sida cuneifolia ointment dose levels of (0.5%, 2.5%, and 5.0%) w/w demonstrated significant (P=0.05) reductions in mice paw volume, with percentage inhibitions of (86.33%, 91.4%, and 91.4%). Dose levels (2.5% and 5%) w/w exhibited more potent activity of (91.4%) compared to that of the reference standard, Diclofenac gel 0.1% w/w. (79.41%). Both dose levels of extract ointments (2.5% and 5.0%) w/w exhibited identical levels of percentage inhibition (91.3%) at the end of 4 hours.
Conclusion: This study provides scientific evidence supporting the ethno-medicinal use of Apical leaves of Sida cuneifolia, suggesting its potential transformative development in ethnomedicine.
Evaluation of response, damage, and repair cost of reinforced concrete super high‐rise buildings subjected to large‐amplitude earthquakes
Authors: Shirai Kazutaka , Okano Hajime , Nakanishi Yuu , Takeuchi Takashi , Sasamoto Katsunori , Sadamoto Miwa , Kusunoki Koichi
Published: December 2023

The present study developed a method for evaluating the response, damage, and repair cost of super high‐rise reinforced concrete (RC) buildings subjected to large‐amplitude earthquakes. The response was numerically assessed using three‐dimensional 40‐story RC frame models under the predicted seismic motions of earthquakes along the Sagami Trough and Nankai Trough considering the effects of slip behavior, slab cooperative width, and stud‐type dampers. Even when the RC mainframe exhibited slip, the peak response deformation was effectively reduced by the friction dampers incorporated into each story. A probabilistic approach based on fragility was used to evaluate the damage and repair cost of the building models. The distributions of the damage states and repair cost for each story under the predicted seismic motions of earthquakes along the Sagami Trough and Nankai Trough were determined, and the total repair cost in relation to the total construction cost was evaluated. The occurrence of damage state 1 had a relatively large effect on the evaluated total repair cost under the evaluation conditions used in this study. A nonlinear relationship was observed between the input magnification and the total repair cost. The friction dampers reduced the damage and total repair cost.
Supporting international women faculty in US institutions: Practice of the “We Hear, We Speak” learning community
Authors: Lin Xi
Published: December 2023

This paper explores, from a practical perspective, the role, and potential outcomes of the We Hear, We Speak (WHWS) learning community in supporting international women faculty and promoting their personal and professional growth. Grounded in the principles of relational cultural theory (RCT), the WHWS community embodies the core practices of the learning community framework. Through its commitment to promoting success in academia, fostering mentoring relationships, and cultivating collaboration and productivity, the community is expected to empower international women faculty to thrive in the US academic realm. By providing a supportive and growth‐oriented space, the WHWS community is anticipated to encourage its members to excel in their academic pursuits. Furthermore, it is expected to not only facilitate the development of mentoring relationships but also promote collaboration and productivity, enabling its members to engage in meaningful partnerships and contribute to the organization's success. In sum, by integrating the principles of RCT and embracing the core practices of the learning community framework, this paper discusses the potential of implementing the WHWS community to foster personal and professional growth, benefiting both individuals and the organization as a whole.
Traditional gender roles and patriarchal values: Critical personal narratives of a woman from the Chaoshan region in China
Authors: Qiu Ruoyi
Published: December 2023

This study utilizes the personal critical narrative of myself, a woman from the Chaoshan region in China, as the primary data source to explore the impact of traditional gender roles and patriarchal values on women's personal growth transformation through a feminist lens. Integrating feminist and transformative learning theory, it encompasses my journey, including growing up with traditional patriarchal norms and thinking; being shaped by traditional gender bias without critical thinking; struggles from valuing males over females; and becoming a feminist‐informed and transformative adult education scholar. This study emphasizes the significance of integrating feminist and transformative learning theories into personal narratives and gender issues in adult education. Through dialogic connections, it may inspire self‐transformation in readers, potentially evolving into informed adult learners and feminist practitioners. This understanding can improve culturally sensitive adult education, fostering inclusivity, empowerment, and enhancing Western researchers’ comprehension of societal norms' influence on personal transformation in diverse contexts.
Transforming adult education through critical feminist theory: Towards a critical consciousness learning model
Authors: Zhu Yidan
Published: December 2023

In this conceptual paper, I delve into the urgent necessity of reshaping adult education and advocate for the adoption of critical feminist theory as a foundational framework for the examination of adult education. Based on the theories of adult education and critical feminist theory, I argue that a critical feminist lens could help educators better support adult learners from diverse backgrounds and spark meaningful social change. Building on principles ofideology,consciousness, andstandpointfrom critical feminist theory, I propose acritical consciousness learning(CCL) model that challenges existing assumptions and inspires innovative research and practice. Ultimately, my objective is to empower adult educators to reimagine the landscape of adult education in a manner that champions principles of equity, inclusivity, and transformative learning, thereby ushering in a new era of adult education.
Few‐Hydrogen Metal‐Bonded Perovskite Superconductor MgHCu3 with a Critical Temperature of 42 K under Atmospheric Pressure
Authors: Tian Chong , He Yong , Zhu Yao‐hui , Du Juan , Liu Shi‐ming , Guo Wen‐hui , Zhong Hong‐xia , Lu Jing , Wang Xinqiang , Shi Jun‐jie
Published: December 2023

Since the prediction of multi‐hydrogen high‐temperature superconductor by Ashcroft in 2004, many possible candidates have been proposed, e.g., LaH10 showing the highest superconducting transition temperature (Tc) around 250–260 K at 170‐200 GPa hitherto. However, this pressure is too large to be taken into practical use. To address this challenge, it proposes a few‐hydrogen metal‐bonded perovskite superconductor, MgHCu3, by combining a novel design idea with first‐principles calculations. Different from multi‐hydrogen hydrides, whose high Tc relies on extreme pressure, the metallic bond in few‐hydrogen superconductor MgHCu3 improves the structural stability and ductility at atmospheric pressure. Here, the small amount of hydrogen is found to be vital for Tc. After the incorporation of hydrogen, the electron–phonon coupling constant of MgHCu3 is increased to 0.83, which is larger than that of the well‐known MgB2. Moreover, the anisotropy of MgHCu3 also plays an important role in enhancing Tc. Based on the Migdal‐Eliashberg theory, it predicts that the phonon‐mediated metal‐bonded perovskite MgHCu3 is a superconductor with Tc of 42 K. The first predicted ternary metal‐bonded perovskite, MgHCu3, enriches the family of perovskite and will promote further investigation on few‐hydrogen superconductors under atmospheric pressure.
Preserving the Li {110} Texture to Achieve Long Cycle Life in Li Metal Electrode at High Rates
Authors: Hu Xitao , Gao Yao , Sun Yongming , Hou Zhen , Luo Yufeng , Wang Danni , Wang Jiangpeng , Zhang Biao , Zheng Zijian , Li Quan
Published: December 2023

{110} textured Li metal electrode shows superior cycle performance when compared to its counterparts with other crystallographic textures or no texture. However, at high rates it suffers from a shortened cycle life that becomes significant with large cycling capacities – a common problem for most alkaline metal electrodes. In the present work, the morphological and structural evolution of the texture‐dependent Li electrodes cycled at different current densities is investigated and discovered that the cycling current density affected both the morphological and the crystallographic texture evolution of Li {110} metal electrode. In particular, loss of {110} texture at increased current densities accelerated the morphological deterioration of Li, leading to roughened Li plating and loose Li packing, and thus promoting the undesired consumption of Li and electrolyte. Thereafter a low‐rate‐healing strategy that significantly elongated the cycle life of Li metal electrode cycled at high rates is proposed. By adopting the healing strategy, a Li||Li symmetrical cell cycled at 10 mA cm−2 with a capacity of 10 mAh cm−2(with a 50% depth of discharge) can last for >800 runs, and a Li||LFP full cell can run for >300 cycles at 5 C with virtually no capacity degradation compared to the first cycle after activation.
Metabolic Response Modulations by Zwitterionic Hydrogels for Achieving Promoted Bone Regeneration
Authors: Li Longwei , Yue Muxin , Peng Qingyu , Pu Xiong , Li Zheng
Published: December 2023

Zwitterionic materials containing both cationic and anionic ligands have been reported to promote hydroxyapaptite (HA)‐mineralization. However, how zwitterionic microenvironment regulates osteogenesis of bone marrow mesenchymal stem cells (BMSCs) and bone regeneration remains elusive. Here, a strategy using zwitterionic (2‐(N‐3‐sulfopropyl‐N, N‐dimethyl ammonium) ethyl methacrylate/ Methacrylated gelatin (DMAPS/GelMA) hydrogel to promote osteogenic differentiation of BMSCs in vitro and enhance bone defect repair in vivo is developed. This zwitterionic hydrogel exhibits high stereo‐affinity of fibronectin III7‐10 (FnIII7‐10) and accelerates endogenous stem cell recruitment during bone regeneration. Then, the metabolic architecture of zwitterion‐guided osteogenesis is explored by using precise untargeted metabolomics, and the metabolic profile is mapped in the zwitterionic microenvironment. The zwitterion‐dependent energetic metabolic profile reveals that amino acids capable of promoting osteogenesis, such as proline and hydroxyproline, are enriched in zwitterionic extracellular matrix (ECM); whereas, fatty acids suggestting the inflammatory response, such as dinoprostone and prostaglandin h2, are enriched in either positive‐charged ECM or negative‐charged ECM. This zwitterionic ECM‐dependent metabolic landscape is the underlying mechanism of zwitterionic hydrogel‐promoted osteogenic differentiation of BMSCs. Therefore, the study provides a deeper contextual understanding of zwitterionic‐directed bone regeneration, leading to stereochemical principles of valuable functionalized biomaterial design.
Trilayer Moiré Superlattices of MoS2 as a Simulator for the Ionic Hubbard Model on Honeycomb Lattice
Authors: Zhong Hongzhen , Su Zhixin , Kang Jun
Published: December 2023

Recent studies have revealed the potential of 2D moiré superlattices as a condensed matter quantum simulator. The realization of different lattice model Hamiltonians in moiré superlattices has become the focus of researches. Here, it shows that, compared to bilayer moiré superlattices where there is only one interface, the interference between moiré patterns at different interfaces in 2D multilayer structures allows the physical realization of more complicated lattice models. The concept is demonstrated by trilayer moiré superlattices (TMSLs) of MoS2, where it finds that isolated flat moiré bands appear near the valence band edge, and they can be described by the honeycomb lattice ionic Hubbard model. More importantly, the hopping strength, the on‐site Coulomb repulsion, and the staggered potential in the TMSLs are highly tunable through the control of the twist angle, the dielectric environment, and the perpendicular electric field. It is possible to achieve various transitions between distinct quantum phases in the TMSLs, spanning from weak to strong correlation regimes. Therefore, the proposed TMSLs can serve as a good platform to study the strong correlation physics in the honeycomb lattice ionic Hubbard model.
Endowing Polyetheretherketone with Anti‐Infection and Immunomodulatory Properties through Guanidination Carbon Dots Modification to Promote Osseointegration in Diabetes with MRSA Infection
Authors: Bai Xinxin , Zhang Xintian , Xiao Jiecheng , Lin Xingyu , Lin Rongjie , Zhang Rui , Deng Xiaoqin , Zhang Menghan , Wei Wenqin , Lan Bin , Weng Shaohuang , Chen Min
Published: December 2023

Methicillin‐resistant Staphylococcus aureus (MRSA) infection and compromised immunity are the severe complications associated with implantation surgery in diabetes mellitus. Enhancing the antibacterial and immunomodulatory properties of implants represents an effective approach to improve the osseointegration of implant in diabetes mellitus. Herein, guanidination carbon dots (GCDs) with antibacterial and immunoregulatory functions are synthesized. The GCDs demonstrate killing effect on MRSA without detectable induced resistance. Additionally, they promote the polarization of macrophages from the M1 to M2 subtype, with the inhibiting pro‐inflammatory cytokines and promoting anti‐inflammatory factors. Correspondingly, GCDs are immobilized onto sulfonated polyether ether ketone (SP@GCDs) using a polyvinyl butyraldehyde (PVB) coating layer through soaking‐drying technique. SP@GCDs maintain stable antibacterial efficacy against MRSA for six consecutive days and retain the immunomodulatory function, while also possessing the long‐term storage stability and biocompatibility of more than 6 months. Moreover, SP@GCDs significantly promote the proliferation and mineralization of osteoblasts. SP@GCDs facilitate osteogenesis through immunoregulatory. Additionally, SP@GCDs exert stable antibacterial and immune regulatory functions in implantation site of a diabetes rat, effectively promoting implant osseointegration regardless of the MRSA infection. These findings provide valuable insights into implant modification through designing nanomaterials with multifunction for enhancing osseointegration of diabetes mellitus, suggesting the promising clinical application prospects.