bluuebunny/crossref_metadata_2025 huggingface dataset:
Parental Deployment and Well-Being in Children
Authors: Mustillo Sarah , Wadsworth Shelley MacDermid , Lester Patricia
Published: October 2015

This study examined whether several aspects of the timing and duration of parental deployment are detrimental to child developmental, emotional, and behavioral health in a random, national probability sample of Army, Navy, Air Force, and Marine Corps families with a child between the ages of birth and 10 years. The study included a telephone interview of 680 families followed by a web-based survey. Results showed that children were exposed to deployment between 1/6 and 1/5 of their lives across all ages studied. We found no association between deployment and problematic social and emotional development in children between the ages of 0 and 5 years. Experiencing a recent long deployment was associated with higher levels of generalized anxiety in children aged 3 to 5 years, and total percentage of life exposed to deployment was associated with elevated social anxiety in the same age group. For older children (6–10 years), having a parent deployed at birth was associated with more total and peer problems, and recent long deployment with more emotional problems. The effects found in this study were modest in size; thus, military children are doing well on average, but for the subset who suffer adverse effects from parental deployment, we suggest several potential services.
“Sclerosing” Pelvic Floor Rhabdomyoma
Authors: Quijano Moreno Sandra Liliana , Lozano Salazar Ana Delina , del Mar Berenguel Ibáñez María , Reina Duarte Ángel , Gonzales Campora Ricardo
Published: October 2015

Purpose. This article reports on a sclerosing perineal-perianal rhabdomyoma in an adult woman. A review of the literature disclosed no reference to this histological form of rhabdomyoma in women. Methods and Results. We describe the case of a 48-year-old woman. At physical examination, a firm nodular lesion was identified in the left lateral perianal-perineal region. Histologically, it comprised rounded and elongated muscle fibers displaying no evident atypia, within a stroma exhibiting marked sclerosis and mild lymphoid infiltrate. At immunohistochemical examination, tumor cells stained for desmin, muscle-specific actin, and myogenin. Conclusions. Skeletal muscle rhabdomyomas are rare benign tumors, generally divided into 3 major categories depending on their clinical and morphological characteristics: fetal, adult, and genital. An unusual histological variant of the genital form has recently been reported in men, characterized by the presence of predominantly mature muscle fibers and marked sclerosis. We document such a lesion in a female patient for the first time.
Pyoblepharitis Vegetans in Association With Pyodermatitis-Pyostomatitis Vegetans
Authors: Dupuis Elaine C. , Haber Richard M. , Robertson Lynne H.
Published: October 2015

Background:

Pyodermatitis-pyostomatitis vegetans (PDPSV) is a rare inflammatory disorder of the skin and oral mucosa that is commonly associated with inflammatory bowel disease (IBD). Ocular involvement is uncommon.

Objective:

Given the association with IBD, it is important for dermatologists to be aware of the varying manifestations of PDPSV.

Methods:

A biopsy was performed for diagnosis confirmation, and the literature was reviewed for similar cases.

Observations:

Our 48-year-old PDPSV patient presented with rare ocular findings. There have been 8 PDPSV reports of ocular involvement. Only 3 of those patients developed blepharitis and/or conjunctival disease. None showed simultaneous involvement of sites at disease onset like our patient.

Results:

Our patient’s concomitant presentation at onset of multiple mucocutaneous sites with blepharitis and conjunctivitis is unique.

Conclusions:

We propose the term pyoblepharitis vegetans (PBV) to describe vegetating lesions of the eyelids. The diagnosis of PDPSPBV should be considered with presentation of these signs.
Availability, spatial accessibility, utilisation and the role of telehealth for multi-disciplinary paediatric cerebral palsy services in Queensland
Authors: Edirippulige Sisira , Reyno John , Armfield Nigel R , Bambling Matthew , Lloyd Owen , McNevin Elizabeth
Published: October 2015

Aims

The purpose of this study was to understand the methods of current delivery of health care services to cerebral palsy (CP) patients in Queensland, Australia. The study also examines the current use of telehealth by clinicians and their perceptions about telehealth use.

Methods

Patient records during July 2013–July 2014 were accessed from the Queensland Paediatric Rehabilitation Service (QPRS) to collect information relating to the service delivery for CP patients. Analysis was carried out to examine the patient locations and travel distances using ArcMap geoprocessing software. In addition, 13 face-to-face semi structured interviews were conducted with clinicians from the QPRS and the Cerebral Palsy Health Service (CPHS) to understand the perceptions of clinicians relating to the current level of health care delivery. We also examined the clinicians’ current use of telehealth and their opinions about this method.

Results

Records of 329 paediatric CP patients were accessed and reviewed. The majority of patients (96%, n = 307) who attended the clinics at the Royal Children's Hospital (RCH), Brisbane, were from remote, rural or regional areas of Queensland. Only 4% of patients ( n = 13) were from major cities. During 12 months, patients had attended nine outreach programmes that were conducted by the QPRS and CPHS. The study found that non-local patients were required to travel an average distance of 836 km to access QPRS and CPHS services in Brisbane. The average distance for receiving a consultation at an outreach clinic was 173 km. Clinicians perceived that access to health care services to CP patients in Queensland is inadequate. Nearly all clinicians interviewed had some experience in using telehealth. They had high satisfaction levels with the method.

Conclusions

Traditional methods of delivering services to CP patients do not meet their needs. Clinicians have found telehealth is a feasible and satisfactory delivery method. However, the use of telehealth is still limited.
Customer citizenship as a reaction to hotel's fair treatment of staff: Service satisfaction as a mediator
Authors: Zoghbi-Manrique-de-Lara Pablo , Suárez-Acosta Miguel A , Guerra-Báez Rita M
Published: October 2015

Little is known about how guests respond to a hotel based on the way they perceive management's treatment of staff. This study suggests that during their stay at the hotel, the more guests witness episodes where staff members are fairly treated, the more they will display (a) satisfaction with hotel service and (b) customer citizenship behaviour directed at the hotel as a whole. It then suggests that (c) service satisfaction serves as a mediator to explain why justice perceptions would lead guests to citizenship behaviour. Data were collected from 343 guests in seven sampled hotels in the Canary Islands (Spain). Results provide support for the effects of justice on citizenship and partial mediation. Given that guests’ citizenship helps the hotel to function, the results warn managers about ‘looking the other way’ or getting involved in episodes of employee mistreatment. In addition, the support for service satisfaction as a mediator suggests that by striving to achieve management's fair treatment of staff, managers also communicate to guests that they aim to provide satisfactory service and, therefore, are deserving of their help.
Numerical solution for the model of RLC circuit via the fractional derivative without singular kernel
Authors: Atangana Abdon , Nieto Juan Jose
Published: October 2015

The numerical approximation of the Caputo–Fabrizio fractional derivative with fractional order between 1 and 2 is proposed in this work. Using the transition from ordinary derivative to fractional derivative, we modified the RLC circuit model. The Crank–Nicolson numerical scheme was used to solve the modified model. We present the stability analysis of the numerical scheme for solving the modified equation and some numerical simulations for different values of the order of derivation.
College Students’ Perceptions of the Links Between Alcohol Use and Sexual Experiences
Authors: Lefkowitz Eva S. , Waterman Emily A. , Morgan Nicole R. , Maggs Jennifer L.
Published: October 2015

Alcohol use is associated with impaired decision making and unwanted sexual outcomes, but emerging adults generally perceive the co-occurrence of alcohol use and sexual behavior positively. The current study examined perceived links between alcohol use and sexual experiences. Data were from 279 college students using stratified random sampling with replacement (56% female, 25% Hispanic/Latino, 22% African American, 28% Asian American/Pacific Islander, and 51% European American; M = 19.95 [0.43] years old). We coded participants’ responses to an open-ended question about how their alcohol use and sexual feelings were related. Students generally perceived that alcohol is facilitative of sex or has no effect. The most common responses were that alcohol leads to arousal and disinhibition. Almost no students mentioned alcohol’s impact on contraceptive use or sexual assault. Results differed by gender, prior sexual behavior, and heavy drinking. We interpret results in light of alcohol myopia theory and discuss implications for prevention.
Maternal body mass index, neonatal lung function and respiratory symptoms in childhood
Authors: Eising Jacobien B. , Uiterwaal Cuno S.P.M. , van der Ent Cornelis K.
Published: November 2015

Recent studies have shown that maternal obesity is associated with increased risk of wheezing in the offspring. We assessed whether impaired neonatal lung function could explain this association.

We measured neonatal lung function in 2606 children of our prospective birth cohort. Information about daily symptoms of wheezing was obtained using questionnaires. Consultations and prescriptions for wheezing illnesses were derived from general practitioner patient files.

Higher maternal body mass index (BMI) was associated with increased risk of wheezing in the first year of life and more consultations and prescriptions for wheezing illnesses until the age of 5 years. Lung function could partially explain the association with wheezing in the first year of life. Adding respiratory resistance to the model decreased the incidence rate ratio from 1.023 (95% CI 1.008–1.039) to 1.015 (95% CI 0.998–1.032). Anthropometrics of the 5-year-olds largely explained the association with consultations. Intermediates or confounders could not explain the association with prescriptions.

There is an association between higher maternal BMI and increased risk of wheezing illnesses. In the first year of life, it is largely explained by an impaired lung function in early life, especially in children of nonatopic mothers. At the age of 5 years, infant lung function is of minor influence in this association.
Severe pulmonary hypertension in lung disease: phenotypes and response to treatment
Authors: Brewis Melanie J. , Church Alistair C. , Johnson Martin K. , Peacock Andrew J.
Published: November 2015

Pulmonary hypertension (PH) due to lung disease (World Health Organization (WHO) group 3) is common, but severe PH, arbitrarily defined as mean pulmonary artery pressure ≥35 mmHg is reported in only a small proportion. Whether these should be treated as patients in WHO group 1 (i.e.pulmonary arterial hypertension) with PH-targeted therapies is unknown.

We compared the phenotypic characteristics and outcomes of 118 incident patients with severe PH and lung disease with 74 idiopathic pulmonary arterial hypertension (IPAH) patients, all treated with pulmonary vasodilators.

Lung disease patients were older, more hypoxaemic, and had lower gas transfer, worse New York Heart Association functional class and lower 6-min walking distance (6MWD) than IPAH patients. Poorer survival in those with lung disease was driven by the interstitial lung disease (ILD) cohort.

In contrast to IPAH, where significant improvements in 6MWD and N-terminal pro-brain natruiretic peptide (NT-proBNP) occurred, PH therapy in severe PH lung disease did not lead to improvement in 6MWD or functional class, but neither was deterioration seen. NT-proBNP decreased from 2200 to 1596 pg·mL−1(p=0.015). Response varied by lung disease phenotype, with poorer outcomes in patients with ILD and emphysema with preserved forced expiratory volume in 1 s. Further study is required to investigate whether vasodilator therapy may delay disease progression in severe PH with lung disease.
Proliferation of East Antarctic Adélie penguins in response to historical deglaciation
Authors: Younger Jane , Emmerson Louise , Southwell Colin , Lelliott Patrick , Miller Karen
Published: October 2015

Background

Major, long-term environmental changes are projected in the Southern Ocean and these are likely to have impacts for marine predators such as the Adélie penguin (Pygoscelis adeliae). Decadal monitoring studies have provided insight into the short-term environmental sensitivities of Adélie penguin populations, particularly to sea ice changes. However, given the long-term nature of projected climate change, it is also prudent to consider the responses of populations to environmental change over longer time scales. We investigated the population trajectory of Adélie penguins during the last glacial-interglacial transition to determine how the species was affected by climate warming over millennia. We focussed our study on East Antarctica, which is home to 30 % of the global population of Adélie penguins.

Methods

Using mitochondrial DNA from extant colonies, we reconstructed the population trend of Adélie penguins in East Antarctica over the past 22,000 years using an extended Bayesian skyline plot method. To determine the relationship of East Antarctic Adélie penguins with populations elsewhere in Antarctica we constructed a phylogeny using mitochondrial DNA sequences.

Results

We found that the Adélie penguin population expanded 135-fold from approximately 14,000 years ago. The population growth was coincident with deglaciation in East Antarctica and, therefore, an increase in ice-free ground suitable for Adélie penguin nesting. Our phylogenetic analysis indicated that East Antarctic Adélie penguins share a common ancestor with Adélie penguins from the Antarctic Peninsula and Scotia Arc, with an estimated age of 29,000 years ago, in the midst of the last glacial period. This finding suggests that extant colonies in East Antarctica, the Scotia Arc and the Antarctic Peninsula were founded from a single glacial refuge.

Conclusions

While changes in sea ice conditions are a critical driver of Adélie penguin population success over decadal and yearly timescales, deglaciation appears to have been the key driver of population change over millennia. This suggests that environmental drivers of population trends over thousands of years may differ to drivers over years or decades, highlighting the need to consider millennial-scale trends alongside contemporary data for the forecasting of species’ abundance and distribution changes under future climate change scenarios.
Treatment of acute rhinitis with a nasal spray containing tramazoline and essential oils: a multicenter, uncontrolled, observational trial
Authors: Katona Gábor , Sultész Mónika , Farkas Zsolt , Gyimesi Andrea , Hirschberg Andor , Huszka János , Radvánszky Ferenc , Simon Ákos , Fülöp Gabriella , Láng Júlia , Ablonczy Mária , Nirnberger Günther , Holm Claudia
Published: November 2015

Background

In this observational trial, data were collected on the effectiveness and tolerability/safety of a nasal spray containing tramazoline and essential oils (trade name Rhinospray® Plus) used for symptomatic treatment of acute rhinitis due to common cold.

Methods

The trial was performed in 300 children, adolescents and adults, who were to be treated with Rhinospray® Plus for up to 4 times per day for up to 10 days. Primary endpoints were the change from baseline to final visit in the mean of three single symptom scores (blocked nose, sneezing, and runny nose) and the mean improvement in two quality‐of‐life parameters (ability to perform normal daytime activities and quality of sleep).

Results

A total of 108 children, 30 adolescents and 162 adults were treated with Rhinospray® Plus. No patient discontinued prematurely. There was a mean reduction of 2.0 ± 0.6 (standard deviation) in nasal symptom scores from baseline to final visit; 297 of 300 of patients (99.0 %) reported an improvement. The mean value for improvement in quality‐of‐life parameters was 1.3 ± 0.5. Improvement in daytime activities was reported by all 300 patients (100.0 %) and in quality of sleep by 292 patients (97.4 %). Effectiveness and tolerability were rated as ‘very good’ or ‘good’ by 95.4 % and 97.4 % of patients, respectively; the investigators rated effectiveness and tolerability as ‘very good’ or ‘good’ for 97.4 % and 100.0 % of patients, respectively. No adverse events were reported.

Conclusions

Community‐based patients reported a relief in acute rhinitis symptoms and improvement in quality of life as a result of treatment with Rhinospray® Plus. Treatment was well‐tolerated.
Detection, classification, and mapping of U.S. traffic signs using google street view images for roadway inventory management
Authors: Balali Vahid , Ashouri Rad Armin , Golparvar-Fard Mani
Published: November 2015

Background

Maintaining an up-to-date record of the number, type, location, and condition of high-quantity low-cost roadway assets such as traffic signs is critical to transportation inventory management systems. While, databases such as Google Street View contain street-level images of all traffic signs and are updated regularly, their potential for creating an inventory databases has not been fully explored. The key benefit of such databases is that once traffic signs are detected, their geographic coordinates can also be derived and visualized within the same platform.

Methods

By leveraging Google Street View images, this paper presents a new system for creating inventories of traffic signs. Using computer vision method, traffic signs are detected and classified into four categories of regulatory, warning, stop, and yield signs by processing images extracted from Google Street View API. Considering the discriminative classification scores from all images that see a sign, the most probable location of each traffic sign is derived and shown on the Google Maps using a dynamic heat map. A data card containing information about location and type of each detected traffic sign is also created. Finally, several data mining interfaces are introduced that allow for better management of the traffic sign inventories.

Results

The experiments conducted on 6.2 miles of I-57 and I-74 interstate highways in the U.S. –with an average accuracy of 94.63 % for sign classification– show the potential of the method to provide quick, inexpensive, and automatic access to asset inventory information.

Conclusions

Given the reliability in performance shown through experiments and because collecting information from Google Street View imagery is cost-effective, the proposed method has potential to deliver inventory information on traffic signs in a timely fashion and tie into the existing DOT inventory management systems. Such spatio-temporal representations provide DOTs with information on how different types of traffic signs degrade over time and further provides useful condition information necessary for predicting sign replacement plan.
Can the MMSE help clinicians predict progression from mild cognitive impairment to dementia?
Authors: Mitchell Alex J.
Published: November 2015

The Mini-Mental State Examination (MMSE) is the most widely used bedside cognitive test. It has previously been shown to be poor as a case-finding tool for both dementia and mild cognitive impairment (MCI). This month's Cochrane Corner review examines whether the MMSE might be used as a risk prediction tool for later dementia in those with established MCI. From 11 studies of modest quality, it appears that the MMSE alone should not be relied on to predict later deterioration in people with MCI. As this is the case, it is likely that only a combination of predictors would be able to accurately predict progression from MCI to dementia.
Practical pharmacotherapy in child psychiatry: an update
Authors: Brown Rachel , James Anthony
Published: November 2015

Psychopharmacology is an increasingly important aspect of child and adolescent psychiatry. The evidence base for the psychopharmacological treatment of depression, anxiety, schizophrenia, bipolar disorder, obsessive—compulsive disorder (OCD) and attention-deficit hyperactivity disorder (ADHD) is increasing. This article presents a synthesis of the information from randomised controlled trials, meta-analyses and the UK NICE guidelines as an aid to practical psychopharmacology.
Psychiatric aspects of diabetes mellitus
Authors: Doherty Anne M.
Published: November 2015

Diabetes is an increasingly common health problem, especially in the West, where there is an emerging epidemic of type 2 diabetes, closely related to the epidemic of obesity. Many people with diabetes struggle to optimise their diabetes control, often because they also have mental illnesses or psychological and social problems. Poor diabetes control has significant consequences for the individual, and if not addressed will result in complications that include blindness, kidney failure and even amputations. There are also consequences for health services resulting from increased admissions and emergency department presentations with diabetes-related difficulties. In the long-term, the costs associated with complications such as renal failure and amputation are high. Addressing the psychiatric and psychological barriers to good glucose control can help reduce the burden of diabetes and its complications on both the individual and the health service.
The psychiatry of children aged 0–4: advances in assessment, diagnosis and treatment
Authors: Foreman David
Published: November 2015

Mental illness in very young children is relatively rare and the number of 0- to 4-year-olds seen in secondary care psychiatric services has recently declined. Conceptualisation of mental illness in this age group is shifting towards a model that views disorders as part of the wider spectrum of diagnoses, rather than distinct, developmentally specific conditions. This article discusses the epidemiology of psychiatric illness in preschool children, evaluates assessment tools that have only recently been validated for use in secondary care and considers evidence of the efficacy and cost-effectiveness of early intervention using treatments encompassing pharmacological, psychological and social approaches.
On Madness and Civilisation: A History of Insanity in
the Age of Reason (1961), by Michel Foucault
Authors: Bracken Pat
Published: November 2015

The original text of this work was published in Paris, in 1961, as
Folie et Déraison: Histoire de la Folie à l'âge
Classique. Madness and Civilisation was the
English translation (by Richard Howard) of an abridged French version from
which 300 pages had been cut. A substantial number of the references from
the first text were also omitted, and the deep scholarship of Foucault's
original work was not fully available to English readers until 2006, when
Routledge published a comprehensive translation of the full book by Jonathan
Murphy and Jean Khalfa. This delay in translation of the full text may
explain the very different reactions to the work in France and in the
English-speaking world. The former were positive in the main. French
historians celebrated the depth of research and Foucault's methodological
originality. English-speaking historians, working with the abbreviated
version only, were generally dismissive. A chorus of reviews challenged the
accuracy of Foucault's historical scholarship. In an important defence of
Foucault, published in 1990, Colin Gordon argued that Histoire de la
Folie was an ‘unknown book’ in the English-speaking world and
went on to show how the answers to most of these historical challenges could
be found in the original French version.
High Royds Hospital, Menston, Ilkley
Authors: Mindham Richard
Published: November 2015

High Royds Hospital was the third of four large hospitals built by the West
Riding of Yorkshire County Council to accommodate ‘pauper lunatics'. The
hospital was designed by the county engineer J. Vickers Edwards, work began
in 1884 and the hospital was opened in 1888. Pavilions were arranged in an
echelon formation with the administrative block, which included a tower and
clock, at the centre and the service area behind, the whole linked by
covered corridors. There were wards designated for the care of patients with
epilepsy and other special groups. Subsequently there were many additions to
the hospital which included an infirmary, long-stay wards detached from the
hospital and a ‘neurosis unit’ built in the modern style in 1938.
The marbled crayfish as a paradigm for saltational speciation by autopolyploidy and parthenogenesis in animals
Authors: Vogt Günter , Falckenhayn Cassandra , Schrimpf Anne , Schmid Katharina , Hanna Katharina , Panteleit Jörn , Helm Mark , Schulz Ralf , Lyko Frank
Published: October 2015

The parthenogenetic all-female marbled crayfish is a novel research model and potent invader of freshwater ecosystems. It is a triploid descendant of the sexually reproducing slough crayfish, Procambarus fallax, but its taxonomic status has remained unsettled. By cross-breeding experiments and parentage analysis we show here that marbled crayfish and P. fallax are reproductively separated. Both crayfish copulate readily, suggesting that the reproductive barrier is set at the cytogenetic rather than the behavioural level. Analysis of complete mitochondrial genomes of marbled crayfish from laboratory lineages and wild populations demonstrates genetic identity and indicates a single origin. Flow cytometric comparison of DNA contents of haemocytes and analysis of nuclear microsatellite loci confirm triploidy and suggest autopolyploidisation as its cause. Global DNA methylation is significantly reduced in marbled crayfish implying the involvement of molecular epigenetic mechanisms in its origination. Morphologically, both crayfish are very similar but growth and fecundity are considerably larger in marbled crayfish, making it a different animal with superior fitness. These data and the high probability of a divergent future evolution of the marbled crayfish and P. fallax clusters suggest that marbled crayfish should be considered as an independent asexual species. Our findings also establish the P. fallax–marbled crayfish pair as a novel paradigm for rare chromosomal speciation by autopolyploidy and parthenogenesis in animals and for saltational evolution in general.
Reliability of ROS and RNS detection in hematopoietic stem cells − potential issues with probes and target cell population
Authors: Vlaski-Lafarge Marija , Ivanovic Zoran
Published: November 2015

Many studies have provided evidence for the crucial role of the reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the regulation of differentiation and/or self-renewal, and the balance between quiescence and proliferation of hematopoietic stem cells (HSCs). Several metabolic regulators have been implicated in the maintenance of HSC redox homeostasis; however, the mechanisms that are regulated by ROS and RNS, as well as their downstream signaling are still elusive. This is partially owing to a lack of suitable methods that allow unequivocal and specific detection of ROS and RNS. In this Opinion, we first discuss the limitations of the commonly used techniques for detection of ROS and RNS, and the problem of heterogeneity of the cell population used in redox studies, which, together, can result in inaccurate conclusions regarding the redox biology of HSCs. We then propose approaches that are based on single-cell analysis followed by a functional test to examine ROS and RNS levels specifically in HSCs, as well as methods that might be used in vivo to overcome these drawbacks, and provide a better understanding of ROS and RNS function in stem cells.
Cadherin-11 endocytosis through binding to clathrin promotes cadherin-11-mediated migration in prostate cancer cells
Authors: Satcher Robert L. , Pan Tianhong , Bilen Mehmet A. , Li Xiaoxia , Lee Yu-Chen , Ortiz Angelica , Kowalczyk Andrew P. , Yu-Lee Li-Yuan , Lin Sue-Hwa
Published: October 2015

Cadherin-11 (Cad11) cell adhesion molecule plays a role in prostate cancer cell migration. Because disassembly of adhesion complexes through endocytosis of adhesion proteins has been shown to play a role in cell migration, we examined whether Cad11 endocytosis plays a role in Cad11-mediated migration. The mechanism by which Cad11 is internalized is unknown. Using a GST pulldown assay, we found that clathrin binds to the Cad11 cytoplasmic domain but not to that of E-cadherin. Using deletion analysis, we identified a unique sequence motif, VFEEE, in the Cad11 membrane proximal region (amino acid residues 11–15) that binds to clathrin. Endocytosis assays using K+-depletion buffer showed that Cad11 internalization is clathrin dependent. Proximity ligation assays showed that Cad11 colocalizes with clathrin, and immunofluorescence assays showed that Cad11 localizes in vesicles that stain for the early endosomal marker Rab5. Deletion of the VFEEE sequence from the Cad11 cytoplasmic domain (Cad11-cla-Δ5) leads to inhibition of Cad11 internalization and reduces Cad11-mediated cell migration in C4-2B and PC3-mm2 prostate cancer cells. These observations suggest that clathrin-mediated internalization of Cad11 regulates surface trafficking of Cad11 and that dynamic turnover of Cad11 regulates the migratory function of Cad11 in prostate cancer cells.
Spatial control of Shoc2 scaffold-mediated ERK1/2 signaling requires remodeling activity of the ATPase PSMC5
Authors: Jang Eun Ryoung , Jang HyeIn , Shi Ping , Popa Gabriel , Jeoung Myoungkun , Galperin Emilia
Published: October 2015

The scaffold protein Shoc2 accelerates activity of the ERK1/2 pathway. Mutations in Shoc2 result in Noonan-like RASopathy, a developmental disorder with a wide spectrum of symptoms. The amplitude of the ERK1/2 signals transduced through the complex is fine-tuned by the HUWE1-mediated ubiquitination of Shoc2 and its signaling partner RAF-1. Here we provide a mechanistic basis of how ubiquitination of Shoc2 and RAF-1 is controlled. We demonstrate that the newly identified binding partner of Shoc2, the (AAA+) ATPase PSMC5, triggers translocation of Shoc2 to endosomes. At the endosomes PSMC5 displaces the E3-ligase HUWE1 from the scaffolding complex to attenuate ubiquitination of Shoc2 and RAF-1. We show that a Rasopathy mutation that changes the subcellular distribution of Shoc2 leads to alterations in Shoc2 ubiquitination due to the loss of accessibility to PSMC5. In summary, our results demonstrate that PSMC5 is a novel critical player involved in regulating ERK1/2 signal transmission through the remodeling of Shoc2 scaffold complex in a spatially-defined manner.
Multimedia Narrative in Public Relations
Authors: Минаева  , Minaeva Lyudmila
Published: November 2015

Global, fast-moving markets require companies to provide increasingly flexible structures and communication networks to constantly interact with their stakeholders. Digital technologies can help companies to drastically change their communication. The purpose of the paper is to consider the use of multimedia narrative in PR texts meant for various corporate key publics: clients, journalists and employees.
Phatica (Fatuor) in a Recruiter Verbal Behavior
Authors: Агеева  , Ageeva Yu.
Published: November 2015

The unique verbal tactics revealed in studies of the communication process

are used as the main strategy by the interviewer during the job interview in

order to run diagnostics of the job seeker. One of such tactics is a special

one based on the phatic function of so-called small talk. Its atypical implementation

aims to inform the recruiter about the degree of conformity of the

job seeker to the position.
A Trip to the XXII Century
Authors: Ключников  , Klyuchnikov S.
Published: November 2015

The article investigates the communication potential of creolized advertising

texts and notes the role of non-verbal component of the advertising text and

its impact on the recipient in conjunction with language and speech means.
PROBLEMS OF THE PSYCHOLOGY AND PEDAGOGICAL ORGANIZATION EDUCATIONAL ENVIRONMENT OF HIGHER EDUCATION INSTITUTION
Authors: Сапронов  , Sapronov Ivan , Уточкина  , Utochkina Elena , Зюкин  , Zyukin P.
Published: November 2015

In article the analysis of problems of the psychology and pedagogical organ-ization of the educational environment of the highest educational institution is car-ried out.
FORMATION OF PSYCHOLOGICAL PREPARATION OF ATH-LETES FOR COMPETITIONS
Authors: Волкова  , Volkova Elena , Григорьева  , Grigoreva Iya , Кузнецов  , Kuznetsov E
Published: November 2015

This article discusses the forms of psychological readiness, as well as an analysis of the main tasks and tools at different stages of sports activities for the perception of the problem of mental states.
INFORMATION SYSTEMS TECHNOLOGY TRANSPORT PRO-CESSES IN MODELS MULTICRITERIA STEPWISE SELECTION
Authors: Кащенко  , Kashchenko S , Белокуров  , Belokurov S , Денисов  , Denisov Gennadiy , Белокуров  , Belokurov Vladimir , Артемов  , Artemov A
Published: November 2015

The task of many criteria choice of effective decisions is given in information-al transport system of any structure from the point of view of a system approach.
MATHEMATICAL JUSTIFICATION PROCESS SORTING FOREST SEEDS BY SIZE
Authors: Новиков  , Novikov Artur
Published: November 2015

Based on the analysis of interaction working body of a separator with forest seeds of coniferous breeds mathematical justification of a choice optimum parame-ters of technological process is given.
Nursery classes in schools
Authors: Kiely Teresa
Published: November 2015

This article explores how school nursery classes can inform and support effective primary school practice, and goes on to illustrate exactly how they can function as standalone early years provision.
We can never stop teaching
Authors: Allingham Sue
Published: November 2015

At the beginning of the Autumn Term I wrote a blog based on what I was reading on the internet and how it reflected current understanding of ‘teaching’. This remains relevant and offers much to reflect on.
What we can learn from… Air transport!
Authors: Chapman Ailsa
Published: November 2015

This month, our focus is once again on transport, with ways and means of travelling through the air lending us inspiration for our learning activities – taking us from balloons to the space race.
The writing on the wall
Authors: Chalmers Debbie
Published: November 2015

Wall displays are a continuous resource for the rooms and areas used by children in the foundation stage, making them a rich and highly valuable contribution to any vibrant learning environment.
Why we ask questions?
Authors: Brown Paula
Published: November 2015

Children ask up to 400 questions a day (about 150,000 a year); many of these are posed on journeys. But why do they, or adults for that matter, ask so many, and when should we choose to use them?
Our native iconic trees
Authors: Williams David
Published: November 2015

When we look for inspiration for our learning activities we can always rely on nature and its rich variety to offer inspiration, for example, there are numerous native trees species, just waiting to be discovered.
Topical and systemic interventions for the treatment of rosacea
Authors: Lavers Isabel
Published: November 2015

Rosacea is a well-recognised chronic inflammatory skin disease of poorly understood aetiology. It is one of the most common skin diseases in adulthood, predominantly occurring in people who are middle-aged and fair-skinned. In the UK, about 4000–5000 new cases are diagnosed each year. Rosacea can significantly affect people's quality of life, often causing considerable psychological distress. Supporting patients with symptom-specific treatments can improve their physiological and psychological wellbeing. Aesthetic practitioners are well placed to either initiate or complement rosacea management, and are often able to offer treatments with limited or no availability on the NHS. This article will look at the pathogenesis, clinical features, diagnosis, triggers and psychosocial complications of rosacea; reflect on an aesthetic patient case study; discuss some effective oral/topical antibiotic therapies and routine skin care; and aim to encourage aesthetic nurses to incorporate the management of rosacea into their portfolio of knowledge and experience, thus effectively including this specialist area of dermatology in their services. Photographs and tables are provided as reference points to aid patient assessment and diagnosis.
Autumn review: reflecting on nursing revalidation and recent conferences
Authors: Senior Yvonne
Published: November 2015

After a busy couple of months, cofounder of the Private Independent Aesthetic Practices Association, Yvonne Senior, takes some time to review the team's achievements and report new developments. She discusses the association's involvement in key events, including this year's Journal of Aesthetic Nursing conference, and announces its recently added preferred partners for members
Rising above a competitive market by becoming oversubscribed and in demand
Authors: Ratcliffe Jason
Published: November 2015

Although running a business in a crowded market can often push owners to think more creatively, this can be detrimental to profits and margins as consumers have more choice and could go elsewhere for the same service. To rise above the rest in medical aesthetics, there are ways in which you can make your clinic oversubscribed, while still providing clients with a remarkable experience, says Jason Ratcliffe
Using the Analytical Network Process (ANP) based on BOCR Model to select the most suitable region for forestation with almond species
Authors: MOHAMMADI MARYAM FAZLOLLAHI , NAJAFI AKBAR , AHMADLO FATEMEH
Published: November 2015

Abstract. Mohammadi MF, Najafi A, Ahmadlo F. 2015. Using the Analytical Network Process (ANP) based on BOCR Model to select the most suitable region for forestation with almond species. Nusantara Bioscience 7: 118-127. Forestation is the answer not only to the growing demand for timber and wood fiber, but also to the problem of deforestation. Forests in arid and semi-arid regions are in the specific conditions because of being in short of water and soil nutrition. Therefore, protection and rehabilitation of these forests is of very important due to its environmental condition as well as selecting suitable species for forestation. Considering all aspects of forestation in an effort to improve forest practices requires an approach that addresses multiple criteria and incorporates a wide range of data. After that, the approach should provide a framework to evaluate both quantitative and qualitative criteria. In this study, the Analytical Network Process (ANP) is utilized to evaluate four existing sites for forestation with Almond (Amygdalus scoparia) in Markazi province, central of Iran. The ANP framework helps forest managers to prioritize all the alternatives and criteria with respect to each other and developing their corresponding preferences. This study is an analysis of the environmental, social-economic, and sustainability-genetic diversion context of forestation with the goal of making forest practices more sustainable. The results indicate that Risk and Cost priorities are more important in making decision (0.53, 0.47), compared to Benefits and Opportunities (0.29, 0.25). The final synthesis of the system shows that Sarabadan (B site) is the best choice among four potential regions which were evaluated for forest plantation based on judgment’s comparisons.
Notes from the Editors, November 2015
Authors: The Editors -
Published: November 2015

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To understand why the Middle East is now in shambles, with the United States currently involved simultaneously in wars against both the Assad government in Syria and the Islamic State in Iraq, generating the greatest refugee crisis in Europe since the Second World War, it is necessary to go back almost a quarter-century to the 1991 Persian Gulf War. The Gulf War, unleashed by the United States in response to Iraq's invasion of Kuwait, was made possible by the growing disorder in the USSR followed by its demise later that same year. The USSR's disappearance from the world stage allowed the United States to shift to a naked imperialist stance—though justified in the manner of the colonial empires of old as "anti-terrorism" and "humanitarian intervention"—not only in the Middle East, but also along the entire great arc that had constituted the perimeter of the former Soviet Union.

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The Great Capitalist Climacteric: Marxism and "System Change Not Climate Change"
Authors: Foster John Bellamy
Published: November 2015

Humanity today is confronted with what might be called the Great Capitalist Climacteric. In the standard definition, a climacteric (from the Greek klimaktēr or rung on the ladder) is a period of critical transition or a turning point in the life of an individual or a whole society. From a social standpoint, it raises issues of historical transformation in the face of changing conditions. In the 1980s environmental geographers Ian Burton and Robert Kates referred to "the Great Climacteric" to address what they saw as the developing global ecological problem of the limits to growth…. I will use the term the Great Capitalist Climacteric here to refer to the necessary epochal social transition associated with the current planetary emergency. It refers both to the objective necessity of a shift to a sustainable society and to the threat to the existence of Homo sapiens (as well as numerous other species) if the logic of capital accumulation is allowed to continue dictating to society as a whole. The current world of business as usual is marked by rapid climate change, but also by the crossing or impending crossing of numerous other planetary boundaries that define "a safe operating space for humanity."

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"A Torture Machine": The Violent Story of Slavery and the Beginning of American Capitalism
Authors: Walker T. W.
Published: November 2015

Edward E. Baptist, The Half Has Never Been Told: Slavery and the Making of American Capitalism (New York: Basic Books, 2014), 528 pages, $35, hardcover.
For an estimated hundreds of thousands of people, including some 60,000 workers who had served notice to their bosses, April 15, 2015, was strike day—reportedly the largest mobilization of low-wage workers since May Day of 1886, when a half million workers and their families (10 percent of the population at the time) struck for the eight-hour work day. Hundreds of us from here in Tennessee joined fast food workers, adjuncts, and home and child-care workers in the morning for strike actions, and many of us boarded buses to St. Louis and Ferguson, Missouri, for a Black Lives Matter protest that brought together strikers and supporters from all across the region. It was an intense and exact showcase of the irrevocable knot of violent and permanent racism in this country, and its broadening (and racialized) wealth and income gap and the deepening, permanent poverty of working-class life.… There is no legitimate history of this nation's past and present that can deny the twin realities of extreme economic exploitation of people of color, especially African Americans, and the incredible violence perpetrated against them. Edward Baptist's The Half Has Never Been Told draws these two realities together in his contribution to the new set of histories of U.S. capitalism, slavery, and cotton, which include Sven Beckert's Empire of Cotton and Walter Johnson's River of Dark Dreams.

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Tree-based language complexity of Thompson's group F
Authors: Taback Jennifer , Younes Sharif
Published: November 2015

The definition of graph automatic groups by Kharlampovich, Khoussainov and Miasnikov and its extension to 𝒞-graph automatic by Elder and the first author raise the question of whether Thompson's group
On transitive differentiable modulo pn functions
Authors: Ivachev Artyom S.
Published: November 2015

For the class of differentiable modulo
Likelihood ratio and score burden tests for detecting disease-associated rare variants
Authors: Lee Woojoo , Lee Donghwan , Pawitan Yudi
Published: November 2015

This paper presents two simple rare variant (RV) burden tests based on the likelihood ratio test (LRT) and score statistics. LRT is one of the commonly used tests in practical data analysis, and we show here that there is no reason to ignore it in testing RV associations. With the Bartlett correction, we have numerically shown that the LRT-based test can have a reliable distribution. Our simulation study indicates that if the non-null variants are as common as the null variants, then the LRT and score statistics have comparable performance to the C-alpha test, and if the former is rarer than the null variants, then they outperform the C-alpha test.
Towards a semiotic definition of discourse and a basis for a typology of discourses
Authors: Boholm Max
Published: November 2015

This article engages with the widely used academic concept of discourse. The aim is threefold: first, to provide a comprehensive overview of how the notion of discourse is conceived based on (a) definitions in the academic literature, (b) dictionary definitions, and (c) corpus data; second, to define discourse as a set of related representations; and, third, to suggest a basis for a typology of discourses. Following Peirce, a representation is regarded as a relationship between a signifier, signified element, and interpretant. A basis for a typology is developed by considering various types of representations and ways they are related.
Rhetorical transformation in Estonian political discourse during World War II
Authors: Ventsel Andreas
Published: November 2015

This article considers the transformations of political rhetoric in Estonian public discourse from the eve of World War II to the retreat of German troops from Estonia in August 1944. Thus, the period under analysis contains the 1940 coup d’état in June, Estonia’s “accession” or “acceptance” to the Soviet Union, and the German occupation of Estonia. The article will analyze how the Estonians’ political and cultural public identity was shaped in political speeches. The analysis will concentrate on the texts that employed the signs important for previous regimes to the introduction and consolidation of new (Soviet and National Socialist) ideological discourses. Using the methods of semiotics and discourse theory, the article will shed light on the metaphorical and metonymical principles of text and meaning construction in the context of power relations. The material of analysis consists of the speeches of the political elite from the 1938, 1939, and 1940 issues of Päevaleht; 1940–1941 issues of Rahva Hääl, and the 1941–1944 issues of Eesti Sõna, and finally, of articles that have been coordinated by the state (published in 1934–1940) in order represent the identity of the Estonian.