bluuebunny/crossref_metadata_2025 huggingface dataset:
Dominant and recessive forms of fibrochondrogenesis resulting from mutations at a second locus, COL11A2
Authors: Tompson Stuart W. , Faqeih Eissa Ali , Ala‐Kokko Leena , Hecht Jacqueline T. , Miki Rika , Funari Tara , Funari Vincent A. , Nevarez Lisette , Krakow Deborah , Cohn Daniel H.
Published: January 2012

Fibrochondrogenesis is a severe, recessively inherited skeletal dysplasia shown to result from mutations in the gene encoding the proα1(XI) chain of type XI collagen, COL11A1. The first of two cases reported here was the affected offspring of first cousins and sequence analysis excluded mutations in COL11A1. Consequently, whole‐genome SNP genotyping was performed to identify blocks of homozygosity, identical‐by‐descent, wherein the disease locus would reside. COL11A1 was not within a region of homozygosity, further excluding it as the disease locus, but the gene encoding the proα2(XI) chain of type XI collagen, COL11A2, was located within a large region of homozygosity. Sequence analysis identified homozygosity for a splice donor mutation in intron 18. Exon trapping demonstrated that the mutation resulted in skipping of exon 18 and predicted deletion of 18 amino acids from the triple helical domain of the protein. In the second case, heterozygosity for a de novo 9 bp deletion in exon 40 of COL11A2 was identified, indicating that there are autosomal dominant forms of fibrochondrogenesis. These findings thus demonstrate that fibrochondrogenesis can result from either recessively or dominantly inherited mutations in COL11A2. © 2012 Wiley Periodicals, Inc.
Nationwide survey of nevoid basal cell carcinoma syndrome in Japan revealing the low frequency of basal cell carcinoma
Authors: Endo Mamiko , Fujii Katsunori , Sugita Katsuo , Saito Kayoko , Kohno Yoichi , Miyashita Toshiyuki
Published: January 2012

Nevoid basal cell carcinoma syndrome (NBCCS) is characterized by developmental defects and tumorigenesis. The clinical manifestations of NBCCS have been reported in large epidemiological studies from the United States, the United Kingdom, and Australia, but not from an Asian country. We conducted a nationwide survey and identified 311 NBCCS patients in Japan. We investigated the detailed clinical manifestations of 157 patients ranging in age from 9 months to 77 years old (mean: 33.1 years). We then compared the frequency and age of onset for various tumors developed in Japanese NBCCS patients with patients from the three countries listed above in which NBCCS studies were previously conducted. Our most significant finding was the low frequency of basal cell carcinoma (BCC) in Japanese patients. Frequency of BCC in patients over 20 years of age was 51.4%, a much lower rate compared to the United States, Australia, and the United Kingdom (91%, 85%, and 73%, respectively). The mean age of BCC onset was 37.4 years of age, a much older age compared to the above‐mentioned countries. These findings suggest that differences in ethnicity and/or environmental factors affect the incidence of BCC. Because the age of BCC onset is generally higher in Japanese NBCCS patients, careful skin examination over a prolonged period of time is warranted. © 2012 Wiley Periodicals, Inc.
Effectively training pediatric residents to deliver diagnoses of Down syndrome
Authors: Lunney Carol A. , Kleinert Harold L. , Ferguson James E. , Campbell Lynn
Published: January 2012

Physicians and parents report a need for pediatricians to have additional training in delivering a diagnosis of Down syndrome (DS). This study tested a web‐based tutorial to assess its effectiveness in improving physicians' perceived comfort with both ambiguous and more medically factual situations as they deliver diagnoses of DS. Based on this web tutorial that integrated prenatal and postnatal information into virtual patient scenarios, the study assessed pediatrics residents' knowledge and comfort in delivering a diagnosis of DS pre and postnatally. A separate survey, given at the same time, asked for residents' perception of their need for this training. Ninety‐one volunteer residents from 10 pediatric training programs across the country participated. The tutorial yielded significant improvement in knowledge and a significant decrease in perceived level of discomfort in both ambiguous situations and more medically certain contexts related to a DS diagnosis. In addition, across all pediatric resident groups (by year, gender, and performance on the knowledge test and the comfort scale), residents strongly agreed that this type of training was beneficial for themselves, other residents, practicing physicians, and other medical professionals. This study suggests that web‐based, interactive, multi‐media training may be an effective tool for improving resident physician comfort with both ambiguous and more medically certain situations in delivering a diagnosis of DS to families. © 2012 Wiley Periodicals, Inc.
A de novo interstitial deletion of 2p23.3–24.3 in a boy presenting with intellectual disability, overgrowth, dysmorphic features, skeletal myopathy, dilated cardiomyopathy
Authors: Shoukier Moneef , Schröder Julia , Zoll Barbara , Burfeind Peter , Freiberg Clemens , Klinge Lars , Kriebel Thomas , Lingen Michael , Mohr Alexander , Brockmann Knut
Published: January 2012

Interstitial deletions of the distal part of chromosome 2p are rare, with only six reported cases involving regions from 2p23 to 2pter. Most of these were cytogenetic investigations. We describe a 14‐year‐old boy with an 8.97 Mb deletion of 2p23.3–24.3 detected by array comparative genomic hybridization (array CGH) who had intellectual disability (ID), unusual facial features, cryptorchidism, skeletal myopathy, dilated cardiomyopathy (DCM), and postnatal overgrowth (macrocephaly and tall stature). We compared the clinical features of the present case to previously described patients with an interstitial deletion within this chromosomal region and conclude that our patient exhibits a markedly different phenotype. Additional patients are needed to further delineate phenotype–genotype correlations © 2012 Wiley Periodicals, Inc.
Low temperature plasma‐initiated precipitation copolymerization of styrene and maleic anhydride
Authors: Yan Da , Xu Xinhua , Ma Guiqiu , Sheng Jing
Published: January 2012

In this study, we show that the plasma‐initiated polymerization (PIP) can be carried out at ambient pressure using the dielectric barrier discharge (DBD) technology. The structure of styrene‐maleic anhydride copolymer (SMA) is analyzed by 1H and 13C‐NMR. The effects of initiation time, gas flow rate, post‐polymerization time, and temperature on yield are also discussed. The results show that SMA exhibits a dominant alternating structure. The yield of SMA increases with the increase of initiation time and polymerization temperature, remains unchanged with the increase of flow rate, and decreases rapidly with the increase of St‐MAH molar ratio. The PIP in this experiment is shown to follow the free‐radical polymerization mechanism and the process of the polymerization is also discussed. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Organosoluble and light‐colored fluorinated semialicyclic polyimide derived from 1,2,3,4‐cyclobutanetetracarboxylic dianhydride
Authors: Lu Yunhua , Hu Zhizhi , Wang Yongfei , Fang Qing Xu
Published: January 2012

In this study, the alicyclic dianhydrides 1,2,3,4‐cyclobutanetetracarboxylic dianhydride (CBDA) was polymerized with seven kinds of fluorinated aromatic diamines, 2,2′‐bis(trifluoromethyl)‐4,4′‐diaminobiphenyl (1), 1,4‐bis(4‐amino‐2‐trifluoromethylphenoxy)benzene (2), 1,4‐bis(4‐amino‐2‐trifluoromethylphenoxy)diphenyl (3), 1,4‐bis(4‐amino‐2‐trifluoromethylphenoxy) diphenyl ether (4), 2,2‐bis[4‐(4‐amino‐2‐trifluoromethylphenoxy)phenyl]hexafluoropropane (5), 4,4′‐bis(4‐amino‐2‐trifluoromethylphenoxy)diphenyl sulfone (6), and 2,7‐bis(4‐amino‐2‐trifluoromethylphenoxy)naphthalene (7), via a two‐step polycondensation procedure to prepare seven kinds of fluorinated semialicyclic polyimides (PI) PI‐1 ∼ PI‐7. The structures of these polyimides were confirmed by infrared spectroscopy (IR). Solubility of the polyimides was tested in various organic solvents and their thermal properties were investigated by dynamic mechanical analysis (DMA) and thermogravimetric analysis (TGA). Ultraviolet‐visible spectra (UV‐vis) and near infrared absorption spectra (NIR) were obtained to evaluate the optical properties of these polyimides. The obtained polyimides PI‐1 ∼ PI‐7 displayed excellent solubility in a variety of organic solvents; they were readily soluble in amide‐type polar solvent. These polyimide films exhibited good optical transparency in the visible light region (400–700 nm) with the transmittance higher than 80% at 450 nm, and these polyimide films showed little absorption at the optocommunication wavelengths of 1.30 and 1.55 μm. These polyimides showed good thermal stability with the 10% thermal decomposing temperatures higher than 443°C in nitrogen and the glass transition temperatures higher than 265°C. In addition, the effect of the structure of fluorinated diamines on the properties of polyimide films was also compared. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Equilibrium adsorption studies on removal of diclofenac sodium from aqueous solution using sawdust–polyaniline (SD–PAn) composites
Authors: Bajpai M. , Rai Neelam , Bajpai S. K.
Published: January 2012

In this work, equilibrium adsorption studies were carried out for the removal of antiinflamatory drug diclofenac sodium (DS) from aqueous solutions using sawdust–polyaniline(SD‐PAn) composite as a potential sorbent at 20, 30, and 40°C. The composite sorbent was characterized by FTIR and SEM analysis. The particles exhibited porous and rough surface. The equilibrium uptake data was interpreted by the Langmuir, the Freundlic, the Temkin, and the Dubinin–Redushkevich (D‐R) isotherm models. The maximum adsorption capacity was found to decrease with increase in temperature, thus indicating exothermic nature of the adsorption process. The thermodynamic parameters were evaluated using Langmuir, Flory–Huggins, Frumkin, and modified‐Frumkin models. The negative values of ΔGads0 and ΔH0 indicated spontaneous and exothermic nature of the adsorption process, respectively. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci 125:1382–1390, 2012
A cost‐effective model for preliminary site evaluation for the reintroduction of a threatened quillwort
Authors: Abeli Thomas , Barni Elena , Siniscalco Consolata , Amosso Cecilia , Rossi Graziano
Published: January 2012

The choice of suitable sites for establishment of a new population of a species is the first step in a translocation programme. However, evaluation of a large number of sites can be demanding of time and money; practitioners need time‐ and cost‐effective evaluation tools.

A predictive model for the preliminary evaluation of potential reintroduction sites was developed using the endangered quillwort Isoëtes malinverniana as a case study. The reliability of three water habitat variables (pH, conductivity, and clarity) as predictors of the presence/absence of I. malinverniana was tested. Three sets of logistic models were produced on the basis of the mean values of pH and conductivity measured over 3, 4 and 6 months to understand whether frequency of measurement affected the reliability of the models. Models of each set were ranked according to AIC and their reliability was then tested using data from the literature.

The conductivity of water and pH were the most effective predictors of the suitability of sites for the reintroduction of I. malinverniana. In particular there was a negative relationship between the presence of I. malinverniana and these variables.

Because of seasonal fluctuations in the variables considered, at least 4 months monitoring are required to obtain reliable results. Despite this, the method is still advantageous in terms of costs, compared with repeated measurements of a wide range of chemical characteristics at a large number of sites.

The main goal of this method is to limit expensive chemical analysis to a few sites chosen after the exclusion of unsuitable sites, through application of the model. Considering the similar ecophysiological features of quillworts from oligotrophic waters, the same model or conceptual framework could be applied to other quillworts and isoetid species growing in degraded areas and needing active conservation.

Copyright © 2012 John Wiley & Sons, Ltd.
Facile Access to Transition‐Metal–Carbonyl Complexes with an Amidinate‐Stabilized Chlorosilylene Ligand
Authors: Azhakar Ramachandran , Ghadwal Rajendra S. , Roesky Herbert W. , Hey Jakob , Stalke Dietmar
Published: January 2012

Three transition‐metal–carbonyl complexes [V(L)(CO)3(Cp)] (1), [Co(L)(CO)(Cp)] (2), and [Co(L2)(CO)3]+[CoCO)4]− (3), each containing stable N‐heterocyclic‐chlorosilylene ligands (L; L=PhC(NtBu)2SiCl) were synthesized from [V(CO)4(Cp)], [Co(CO)2(Cp)], and Co2(CO)8, respectively. Complexes 1, 2, 3 were characterized by NMR and IR spectroscopy, EI‐MS spectrometry, and elemental analysis. The molecular structures of compounds 1, 2, 3 were determined by single‐crystal X‐ray diffraction.
Multimetric spatial optimization of switchgrass plantings across a watershed
Authors: Parish Esther S. , Hilliard Michael R. , Baskaran Latha M. , Dale Virginia H. , Griffiths Natalie A. , Mulholland Patrick J. , Sorokine Alexandre , Thomas Neil A. , Downing Mark E. , Middleton Richard S.
Published: January 2012

The increasing demand for bioenergy crops presents our society with the opportunity to design more sustainable landscapes. We have created a Biomass Location for Optimal Sustainability Model (BLOSM) to test the hypothesis that landscape design of cellulosic bioenergy crop plantings may simultaneously improve water quality (i.e. decrease concentrations of sediment, total phosphorus, and total nitrogen) and increase profits for farmer‐producers while achieving a feedstock‐production goal. BLOSM was run using six scenarios to identify switchgrass (Panicum virgatum) planting locations that might supply a commercial‐scale biorefinery planned for the Lower Little Tennessee (LLT) watershed. Each scenario sought to achieve different sustainability goals: improving water quality through reduced nitrogen, phosphorus, or sediment concentrations; maximizing profit; a balance of these conditions; or a balance of these conditions with the additional constraint of converting no more than 25% of agricultural land. Scenario results were compared to a baseline case of no land‐use conversion. BLOSM results indicate that a combined economic and environmental optimization approach can achieve multiple objectives simultaneously when a small proportion (1.3%) of the LLT watershed is planted with perennial switchgrass. The multimetric optimization approach described here can be used as a research tool to consider bioenergy plantings for other feedstocks, sustainability criteria, and regions. Published in 2012 by John Wiley & Sons, Ltd
The third Industrial Revolution
Authors: Fischler Franz
Published: January 2012

Mr Franz Fischler, Former European Commissioner for Agriculture, Rural Development and Fisheries, puts the case for a third Industrial Revolution for a more sustainable future and the need for a clear strategy for the material use of biomass. © 2012 Society of Chemical Industry and John Wiley & Sons, Ltd.
Intelligent Diagnosing of Intellectual Disabilities in Offenders: Food for Thought
Authors: Uzieblo Katarzyna , Winter Jan , Vanderfaeillie Johan , Rossi Gina , Magez Walter
Published: January 2012

Research on offenders with intellectual disabilities (IDs) in the criminal justice arena is on the rise, reflected by a growing number of relevant publications each year. However, there is a long recognized methodological problem that hampers the comparability of empirical studies and that raises doubts about the accuracy of prevalence rates, comorbidities, and various correlates and characteristics. In this paper we will argue that the crux of the problem can, on the one hand, be found in the plurality of assessment methods for intelligence and adaptive functioning, which are not all sufficiently reliable and valid. On the other hand, assessment of IQ in criminal justice and mental health‐related areas appears to be informed more by practical aspects and needs rather than grounded in a solid theoretical model. Hence, we suggest that the Cattell–Horn–Carroll (CHC) model of intelligence has potential value in this regard, and deserves a closer look. Finally, we will discuss its incorporation into, and possible implications for, criminal justice practice and future study designs. Copyright © 2012 John Wiley & Sons, Ltd.
Molecularly imprinted cryogel for L‐glutamic acid separation
Authors: Aydoğan Cemil , Andaç Muge , Bayram Engin , Say Rıdvan , Denizli Adil
Published: January 2012

A molecular recognition based L‐glutamic acid (L‐GLU) imprinted cryogel was prepared for L‐GLU separation via chromatographic applications. The novel functional monomer N‐methacryloyl‐(L)‐glutamic acid‐Fe3+ (MAGA‐Fe3+) was synthesized to be complex with L‐GLU. The L‐GLU imprinted cryogel was prepared by free radical polymerization under semifrozen conditions in the presence of a monomer‐template complex MAGA‐Fe3+‐L‐GLU. The binding mechanism of MAGA‐Fe3+ and L‐GLU was characterized by Fourier transform infrared (FTIR) spectroscopy in detail. FTIR analyses on the synthesized MAGA‐Fe3+‐GLU complex reveals bridging bidentate and monodentate binding modes of Fe3+ in complex with the carboxylate groups of the glutamate residues. The template L‐GLU could be reversibly detached from the cryogel to form the template cavities using a 100 mM solution of HNO3. The amount of adsorbed L‐GLU was detected using the phenyl isothiocyanate method. The L‐GLU adsorption capacity of the cryogel decreased drastically from 11.3 to 6.4 μmol g−1 as the flow rate increased from 0.5 to 4.0 mL min−1. The adsorption onto the L‐GLU imprinted cryogel was highly pH dependent due to electrostatic interaction between the L‐GLU and MAGA‐Fe3+. The PHEMAGA‐Fe3+‐GLU cryogel exhibited high selectivity to the corresponding guest amino acids (i.e., D‐GLU, L‐ASN, L‐GLN, L‐, and D‐ASP). Finally, the L‐GLU imprinted cryogel was recovered and reused many times, with no significant decrease in their adsorption capacities. © 2012 American Institute of Chemical Engineers Biotechnol. Prog., 2012
Award of Merit acceptance speech: Bridges, linchpins and membranes: From I to We
Authors: Marchionini Gary
Published: January 2012

Editor's Summary

Accepting the ASIS&T Award of Merit for 2011, Gary Marchionini reflected on his early career in mathematics education and its synergies with information science. He observed that information scientists are connectors and that the field itself is based on establishing connectivity. We create mappings or links between elements, such as maps between search queries and documents, between databases and information objects, between concepts and taxonomies, between searchers' mental models and interfaces. Mapping such relationships is similar to a bridge spanning spaces and cultures, a linchpin coupling an engine and load, and a membrane regulating cellular transport in that each relates sets of properties. In the sphere of human interactions, relationships enable us to move from “I” to “we.” Marchionini expressed appreciation for connections made through ASIS&T and looked ahead to making and studying intellectual and social connections in the field and the organization.
Personal and professional information management
Authors: Pfeiffer Heather D. , Tonkin Emma
Published: January 2012

Editor's Summary

Managing perceptions about personal and professional information on the social web is the focus of this Bulletin issue. Contributors offer insights on analyzing our personal presence online to determine whether it accurately reflects ourselves as we intend and on actively creating a personal knowledge profile. We can gain some control over our personal information and its unintended spread by separating social networking with personal information from professional web content and using privacy settings. The importance of user monitoring and participation is emphasized in observations about personal health records. Tools are being developed to limit software that accesses context‐aware personally identifiable information. Information sharing and reuse can perpetuate false information, though content analysis of tweets about a series of events shows that irrelevant and contradictory Twitter comments fade rapidly from circulation. Knowledge management within organizations is spotlighted to explore how enterprises learn, grow and are affected by each other in a competitive environment. The many examples presented demonstrate the urgent need to actively manage the proliferation of personal and professional information on social networks.
Analyzing personal presence on the Web and building your brand
Authors: Murdock Donyelle
Published: January 2012

Editor's Summary

The web is a vast collection point for data about individuals and organizations, whether true or false, flattering or misrepresentative. Since checking a person's background, credentials and professional and social circles has become routine, we should be aware of our own digital footprint and actively manage the information available about us to ensure it reflects the image we want to project. Building a personal brand online should be based on active involvement, including reading blogs in our interest areas and participating in blog discussions. It is important to use one's real name to avoid falling liable to misidentification. Having a Facebook page permits one to build and control a network, and exploring Twitter enables one to keep up with and contribute to current communications on topics of interest. By proactively building our personal brand online, we can control our identity, image and reputation in the digital world.
Knowledge gained from action and reaction learning in small and medium‐sized enterprises: Two sides of the same coin
Authors: Sarabia Maria , Obeso Maria
Published: January 2012

Editor's Summary

In competitive business market systems, small to medium‐sized enterprises (SMEs) interact continually as leaders and followers. SMEs can engage in active learning, leading the way and learning from the consequences, or they can learn reactively by observing and imitating rivals in their competitive environment. Integrating a theory of action learning with a theory relating learning levels with organizational change leads to the concept of reaction learning. This theoretical view of learning fits the observed behavior of SMEs in a competitive environment. Recognizing both action and reaction learning promotes better understanding of how those in the business community make strategic decisions and learn from their own experiences and from their competitors.
Want to improve your coordination? Attend to patterns
Authors: Haller Thom
Published: January 2012

Editor's Summary

The concept of uncoordination can apply not only to clumsiness but also to disorganization in information architecture. Confusing and disorderly information is widespread, but information can be structured to improve website clarity by recognizing and judiciously using patterns and components in information architecture. A pattern is a consistent and recurring feature, and components are reusable element packages or modules. Information architects can analyze and deconstruct a site design to identify its components and assemble them into a component library. Patterns and components simplify the site developer's process and lend consistency and visual clarity for the site visitor, resulting in a better user experience. By following simple steps for identifying patterns and components across a web site, information architects can bring coordination and structure to the overall site.
Nanoscale Biocoordination Polymers: Novel Materials from an Old Topic
Authors: Liu Yaling , Tang Zhiyong
Published: January 2012

Nature bestows many gifts upon us, among which countless biomolecules have the ability to bridge metal ions and exert the important function in biology. By taking advantage of specific interactions between metal ions and biomolecules, this article highlights a novel concept for construction of nanoscale biocoordination polymers through replacement of synthetic organic molecules with natural biomolecules as building blocks. The most recent advances are summarized and future challenges are discussed. It can be anticipated that nanoscale biocoordination polymers will become a diverse and rapidly growing class of novel materials and potentially lead to a breakthrough in biological applications.
Synthesis of Uniform Layered Protonated Titanate Hierarchical Spheres and Their Transformation to Anatase TiO2 for Lithium‐Ion Batteries
Authors: Wu Hao Bin , Lou Xiong Wen (David) , Hng Huey Hoon
Published: January 2012

Layered protonated titanates (LPTs), a class of interesting inorganic layered materials, have been widely studied because of their many unique properties and their use as precursors to many important TiO2‐based functional materials. In this work, we have developed a facile solvothermal method to synthesize hierarchical spheres (HSs) assembled from ultrathin LPT nanosheets. These LPT hierarchical spheres possess a porous structure with a large specific surface area and high stability. Importantly, the size and morphology of the LPT hierarchical spheres are easily tunable by varying the synthesis conditions. These LPT HSs can be easily converted to anatase TiO2 HSs without significant structural alteration. Depending on the calcination atmosphere of air or N2, pure anatase TiO2 HSs or carbon‐supported TiO2 HSs, respectively, can be obtained. Remarkably, both types of TiO2 HSs manifest excellent cyclability and rate capability when evaluated as anode materials for high‐power lithium‐ion batteries.
100 Picosecond Diffraction Catches Structural Transients of Laser‐Pulse Triggered Switching in a Spin‐Crossover Crystal
Authors: Collet Eric , Lorenc Maciej , Cammarata Marco , Guérin Laurent , Servol Marina , Tissot Antoine , Boillot Marie‐Laure , Cailleau Hervé , Buron‐Le Cointe Marylise
Published: January 2012

We study by 100 picosecond X‐ray diffraction the photo‐switching dynamics of single crystal of the orthorhombic polymorph of the spin‐crossover complex [(TPA)Fe(TCC)]PF6, in which TPA=tris(2‐pyridyl methyl)amine, TCC2−=3,4,5,6‐Cl4‐Catecholate2−. In the frame of the emerging field of dynamical structural science, this is made possible by using optical pump/X‐ray probe techniques, which allow following in real time structural reorganization at intra‐ and intermolecular levels associated with the change of spin state in the crystal. We use here the time structure of the synchrotron radiation generating 100 picosecond X‐ray pulses, coupled to 100 fs laser excitation. This study has revealed a rich variety of structural reorganizations, associated with the different steps of the dynamical process. Three consecutive regimes are evidenced in the time domain: 1) local molecular photo‐switching with structural reorganization at constant volume, 2) volume relaxation with inhomogeneous distribution of local temperatures, 3) homogenization of the crystal in the transient state 100 µs after laser excitation. These findings are fundamentally different from those of conventional diffraction studies of long‐lived photoinduced high spin states. The time‐resolution used here with picosecond X‐ray diffraction probes different physical quantities on their intrinsic time‐scale, shedding new light on the successive processes driving macroscopic switching in a functionalized material. These results pave the way for structural studies away from equilibrium and represent a first step toward femtosecond crystallography.
Tuning the Physicochemical Properties of Diverse Phenolic Ionic Liquids for Equimolar CO2 Capture by the Substituent on the Anion
Authors: Wang Congmin , Luo Huimin , Li Haoran , Zhu Xiang , Yu Bo , Dai Sheng
Published: January 2012

Phenolic ionic liquids for the efficient and reversible capture of CO2 were designed and prepared from phosphonium hydroxide and substituted phenols. The electron‐withdrawing or electron‐donating ability, position, and number of the substituents on the anion of these ionic liquids were correlated with the physicochemical properties of the ionic liquids. The results show that the stability, viscosity, and CO2‐capturing ability of these ionic liquids were significantly affected by the substituents. Furthermore, the relationship between the decomposition temperature, the CO2‐absorption capacity, and the basicity of these ionic liquids was quantitatively correlated and further rationalized by theoretical calculation. Indeed, these ionic liquids showed good stability, high absorption capacity, and low absorption enthalpy for CO2 capture. This method, which tunes the physicochemical properties by making use of substituent effects in the anion of the ionic liquid, is important for the design of highly efficient and reversible methods for CO2‐capture. This CO2 capture process using diverse phenolic ionic liquids is a promising potential method for CO2 absorption with both high absorption capacity and good reversibility.
On the Mechanism of the Palladium‐Catalyzed β‐Arylation of Ester Enolates
Authors: Larini Paolo , Kefalidis Christos E. , Jazzar Rodolphe , Renaudat Alice , Clot Eric , Baudoin Olivier
Published: January 2012

The palladium‐catalyzed β‐arylation of ester enolates with aryl bromides was studied both experimentally and computationally. First, the effect of the ligand on the selectivity of the α/β‐arylation reactions of ortho‐ and meta‐fluorobromobenzene was described. Selective β‐arylation was observed for the reaction of o‐fluorobromobenzene with a range of biarylphosphine ligands, whereas α‐arylation was predominantly observed with m‐fluorobromobenzene for all ligands except DavePhos, which gave an approximate 1:1 mixture of α‐/β‐arylated products. Next, the effect of the substitution pattern of the aryl bromide reactant was studied with DavePhos as the ligand. We showed that electronic factors played a major role in the α/β‐arylation selectivity, with electron‐withdrawing substituents favoring β‐arylation. Kinetic and deuterium‐labeling experiments suggested that the rate‐limiting step of β‐arylation with DavePhos as the ligand was the palladium–enolate‐to‐homoenolate isomerization, which occurs by a βH‐elimination, olefin‐rotation, and olefin‐insertion sequence. A dimeric oxidative‐addition complex, which was shown to be catalytically competent, was isolated and structurally characterized. A common mechanism for α‐ and β‐arylation was described by DFT calculations. With DavePhos as the ligand, the pathway leading to β‐arylation was kinetically favored over the pathway leading to α‐arylation, with the palladium–enolate‐to‐homoenolate isomerization being the rate‐limiting step of the β‐arylation pathway and the transition state for olefin insertion its highest point. The nature of the rate‐limiting step changed with PCy3 and PtBu3 ligands, and with the latter, α‐arylation became kinetically favored. The trend in selectivity observed experimentally with differently substituted aryl bromides agreed well with that observed from the calculations. The presence of electron‐withdrawing groups on these bromides mainly affected the α‐arylation pathway by disfavoring CC reductive elimination. The higher activity of the ligands of the biaryldialkylphosphine ligands compared to their corresponding trialkylphosphines could be attributed to stabilizing interactions between the biaryl backbone of the ligands and the metal center, thereby preventing deactivation of the β‐arylation pathway.
Monodisperse REPO4 (RE=Yb, Gd, Y) Hollow Microspheres Covered with Nanothorns as Affinity Probes for Selectively Capturing and Labeling Phosphopeptides
Authors: Cheng Gong , Zhang Ji‐Lin , Liu Yan‐Lin , Sun De‐Hui , Ni Jia‐Zuan
Published: January 2012

Rare‐earth phosphate microspheres with unique structures were developed as affinity probes for the selective capture and tagging of phosphopeptides. Prickly REPO4 (RE=Yb, Gd, Y) monodisperse microspheres, that have hollow structures, low densities, high specific surface areas, and large adsorptive capacities were prepared by an ion‐exchange method. The elemental compositions and crystal structures of these affinity probes were confirmed by energy‐dispersive spectroscopy (EDS), powder X‐ray diffraction (XRD), and Fourier‐transform infrared (FTIR) spectroscopy. The morphologies of these compounds were investigated using scanning electron microscopy (SEM), transmission electron microscopy (TEM), and nitrogen‐adsorption isotherms. The potential ability of these microspheres for selectively capturing and labeling target biological molecules was evaluated by using protein‐digestion analysis and a real sample as well as by comparison with the widely used TiO2 affinity microspheres. These results show that these porous rare‐earth phosphate microspheres are highly promising probes for the rapid purification and recognition of phosphopeptides.
ChemInform Abstract: Rational Syntheses and Structural Characterization of Sulfur‐Rich Phosphorus Polysulfides: α‐P2S7 and β‐P2S7.
Authors: Roedl Thomas , Weihrich Richard , Wack Julia , Senker Juergen , Pfitzner Arno
Published: January 2012

The polysulfides α‐ and β‐P2S7 are synthesized by heating stoichiometric mixtures of P4S3 and sulfur in the presence of catalytic amounts of anhydrous FeCl3 as mineralizer (evacuated silica tube, 250 °C, 10 d).
ChemInform Abstract: Effect of Alkali‐Metal Ions on the Local Structure and Luminescence for Double Tungstate Compounds AEu(WO4)2 (A: Li, Na, K).
Authors: Huang Jinping , Xu Jun , Luo Hongshan , Yu Xibin , Li Yikang
Published: January 2012

The title compounds are synthesized by solid state reactions of NaHCO3, Li2CO3, or K2WO4, WO3, and Eu2O3 (porcelain crucible, 750 °C, 10 h).
ChemInform Abstract: Syntheses, Structures, and Magnetic and Thermoelectric Properties of Double‐Tunnel Tellurides: AxLn2Cu6‐xTe6 (A: K—Cs; Ln: La—Nd).
Authors: Meng Chang‐Yu , Chen Hong , Wang Peng , Chen Ling
Published: January 2012

The new compounds Cs0.75La2Cu5.25Te6, Cs0.77Ce2Cu5.23Te6, Cs0.73Pr2Cu5.27Te6, Cs0.75Nd2Cu5.25Te6, Rb0.72La2Cu5.29Te6, Rb0.71Ce2Cu5.29Te6, Rb0.65Pr2Cu5.35Te6, Rb0.70Nd2Cu5.30Te6, K0.73La2Cu5.27Te6, K0.73Ce2Cu5.27Te6, K0.76Pr2Cu5.24Te6, and K0.77Nd2Cu5.23Te6 are synthesized from the elements in a reactive MCl flux (M: K—Cs) at 1123 K.
ChemInform Abstract: Synthesis, Crystal Structure and Magnetic Properties of the Open Framework Compound Co3Te2O2(PO4)2 (OH)4.
Authors: Zimmermann Iwan , Kremer Reinhard K. , Johnsson Mats
Published: January 2012

Single crystals of the title compound are hydrothermally synthesized from a mixture of CoCl2, TeO2, NH4H2PO4, and H2O (autoclave, 180 °C, 7 d).
ChemInform Abstract: New 8‐Layer Twinned Hexagonal Perovskite Microwave Dielectric Ceramics Ba8Ga4‐xTa4+0.6xO24.
Authors: Cao Jiang , Kuang Xiaojun , Allix Mathieu , Dickinson Calum , Claridge John B. , Rosseinsky Matthew J. , Iddles David M. , Su Qiang
Published: January 2012

The title perovskite (0 ≤ x ≤ 3.6) is synthesized from stoichiometric amounts of BaCO3, Ga2O3, and Ta2O5 (1200 °C for 12 h and 1450 °C for 24 h).
ChemInform Abstract: Synthesis, Structural and Electrical Characterizations of DySr5Ni2.4Cu0.6O12‐ δ.
Authors: Hamdi S. , Ouni S. , Chaker H. , Rohlicek J. , Ben Hassen R.
Published: January 2012

The new title compound is synthesized by a sol—gel method from stoichiometric amounts of Nd2O3, SrCO3, NiO, and CuO dissolved in an aqueous nitric acid solution containing citric acid and ethylene glycol followed by calcination of the resulting product at 1173 K for 24 h in an alumina crucible, and annealing under flowing Ar at 1473 K for 8 d.
ChemInform Abstract: Carbon—Carbon Bond‐Forming Reactions of α‐Carbonyl Carbocations: Exploration of a Reversed‐Polarity Equivalent of Enolate Chemistry.
Authors: Lai Ping‐Shan , Dubland Joshua A. , Sarwar Mohammed G. , Chudzinski Michael G. , Taylor Mark S.
Published: January 2012

Silver‐promoted ionization of α‐halocarbonyl compounds generates the corresponding α‐carbonyl carbocations which smoothly react with simple (het)arenes as nucleophiles to give diarylcarbonyl compounds, e.g. (III), (V)/(VI) and (XII).
ChemInform Abstract: Regioselective Synthesis of β‐Iodo‐enamides and β‐Yn‐enamides.
Authors: Pasqua Adele E. , Thomas Lynne H. , Crawford James J. , Marquez Rodolfo
Published: January 2012

Chromium‐mediated olefination of N‐formyl imides with iodoform provides an efficient access towards β‐iodoenamides.
ChemInform Abstract: New Reactivity of Oxaziridine: Pd(II)‐Catalyzed Aromatic C—H Ethoxycarbonylation via C—C Bond Cleavage.
Authors: Peng Xingao , Zhu Yingguang , Ramirez Thomas A. , Zhao Baoguo , Shi Yian
Published: January 2012

A variety of substrates can be used with success in the reaction with (II).
ChemInform Abstract: syn‐Selective Asymmetric Cross‐Aldol Reactions Between Aldehydes and Glyoxylic Acid Derivatives Catalyzed by an Axially Chiral Amino Sulfonamide.
Authors: Kano Taichi , Noishiki Akira , Sakamoto Ryu , Maruoka Keiji
Published: January 2012

The cross‐aldol products (III), (V) and (VII) are highly functionalized and readily converted to synthetically useful and important chiral building blocks such as γ‐lactone (VIII) and γ‐lactam (X).
ChemInform Abstract: TiCl4—Et2AlCl‐Catalyzed Cycloaddition of 1,2‐Dienes to 1,3,5‐Cycloheptatriene.
Authors: D'yakonov V. A. , Nadikova G. N. , Khalilov L. M. , Dzhemilev U. M.
Published: January 2012

Substituted endo‐bicyclo[4.2.1]nona‐2,4‐dienes are obtained by catalytic codimerization of 1,3,5‐cycloheptatriene (I) with 1,2‐dienes (II) in the presence of the title two‐component catalytic system.
ChemInform Abstract: FeBr3‐Catalyzed Dibromination of Alkenes and Alkynes.
Authors: Zheng Yun Fa , Yu Jian , Yan Guo Bing , Li Xu , Luo Song
Published: January 2012

Optimized conditions are developed for the selective trans dibromination of terminal aryl alkynes.
ChemInform Abstract: Nano TiO2 as a Heterogeneous Catalyst in an Efficient One‐Pot Three‐Component Mannich Synthesis of β‐Aminocarbonyls.
Authors: Kassaee M. Z. , Mohammadi Reza , Masrouri Hassan , Movahedi Farnaz
Published: January 2012

Moderate to good anti‐selectivity is observed for cyclic ketones with the exception of (IVa/Va).
ChemInform Abstract: Efficient Indoles and Anilines Synthesis Employing tert‐Butyl Sulfinamide as Ammonia Surrogate.
Authors: Prakash Anjanappa , Dibakar Mullick , Selvakumar Kumaravel , Ruckmani Kandasamy , Sivakumar Manickam
Published: January 2012

Palladium catalyzed coupling of sulfinamide (II) with aryl halides gives sulfinated anilines which can be deprotected with HCl.
ChemInform Abstract: A Highly Active Nano‐Palladium Catalyst for the Preparation of Aromatic Azos under Mild Conditions.
Authors: Hu Lei , Cao Xueqing , Shi Linyan , Qi Fenqiang , Guo Zhiqiang , Lu Jianmei , Gu Hongwei
Published: January 2012

The worm‐like Pd nanomaterial allows the preparation of various symmetrical and unsymmetrical azo compounds.
ChemInform Abstract: Direct and Mild Palladium‐Catalyzed Aerobic Oxidative Synthesis of Imines from Alcohols and Amines under Ambient Conditions.
Authors: Jiang Lan , Jin Luolu , Tian Haiwen , Yuan Xueqin , Yu Xiaochun , Xu Qing
Published: January 2012

By ligand, (TEMPO) and base screening a mild one pot imine synthesis from benzylic alcohols (I) and amines (II) via a Pd‐catalyzed tandem aerobic alcohol oxidation/dehydrative condensation sequence is developed.
ChemInform Abstract: Cyanocuprates Convert Carboxylic Acids Directly into Ketones.
Authors: Genna Douglas T. , Posner Gary H.
Published: January 2012

The reaction of various carboxylic acids with excess cyanocuprates leads to ketone products whose yields depend on the substitution pattern of the organometal reagent.
ChemInform Abstract: Organocatalytic Asymmetric Aldol Reaction of Hydroxyacetone with β,γ‐Unsaturated α‐Keto Esters: Facile Access to Chiral Tertiary Alcohols.
Authors: Liu Chen , Dou Xiaowei , Lu Yixin
Published: January 2012

The reaction is effective only for aromatic ketoesters.
ChemInform Abstract: Microwave Promoted Rapid Dehydration of Aldoximes to Nitriles Using Melamine‐Formaldehyde Resin Supported Sulfuric Acid in Dry Media.
Authors: Rezaei Ramin , Karami Marzeih
Published: January 2012

The process allows the conversion of aromatic and aliphatic aldoximes in short reaction times.
ChemInform Abstract: Synthesis of tert‐Butyl Peresters from Aldehydes by Bu4NI‐Catalyzed Metal‐Free Oxidation and Its Combination with the Kharasch—Sosnovsky Reaction.
Authors: Wei Wei , Zhang Chao , Xu Yuan , Wan Xiaobing
Published: January 2012

A new tert‐butyl perester synthesis directly from aldehydes (I) and tert‐butyl hydroperoxide (II) is developed via Bu4NI‐catalyzed aldehyde C—H oxidation.
ChemInform Abstract: Convenient One‐Pot Synthesis of Sulfonamides and Sulfonyl Azides from Thiols Using N‐Chlorosuccinimide.
Authors: Veisi Hojat , Ghorbani‐Vaghei Ramin , Hemmati Saba , Mahmoodi Jafar
Published: January 2012

A procedure is developed which produces alkyl and aryl sulfonyl chlorides from the corresponding thiols in the first step followed by direct one‐pot conversion to the title compounds.
ChemInform Abstract: Silicon‐Mediated Synthesis and Selected Transformations of β‐Chloroketones.
Authors: Salama Tarek A. , Elmorsy Saad S.
Published: January 2012

The attempt to use aliphatic unsaturated ketones or arylidenes of alicyclic ketones fails.The β‐chloroketones are converted into tetrazoles and β‐amidoketones and SiCl4 can be applied in all transformation as an efficient reagent.
ChemInform Abstract: Suzuki—Miyaura Cross‐Coupling of Benzylic Bromides under Microwave Conditions.
Authors: McDaniel Steven W. , Keyari Charles M. , Rider Kevin C. , Natale Nicholas R. , Diaz Philippe
Published: January 2012

The optimized conditions allow the preparation of a library of structurally diverse products what is of interest for SAR studies in the field of isoxazole drugs.
ChemInform Abstract: Highly Diastereoselective and General Synthesis of Primary β‐Fluoroamines.
Authors: Schulte Michael L. , Lindsley Craig W.
Published: January 2012

Various title compounds can be prepared in a diastereoselective manner starting with the reaction between aldehydes (I) and optically active sulfimine (II).
ChemInform Abstract: Hexatriene Formation from the Regiospecific Alkene Cross‐Metathesis of trans‐1‐(Buta‐1,3‐dien‐1‐yl)‐2‐acryloyloxynaphthalene.
Authors: Gabbutt Christopher D. , Heron B. Mark , Kilner Colin , Kolla Suresh B.
Published: January 2012

Attempted synthesis of the medium‐ring size lactone naphthoxocinone via ring‐closing metathesis of readily available acrylate ester (V) fails but yields the hexatriene (VI).
ChemInform Abstract: Expeditious Synthesis of Phenanthrenes via CuBr2‐Catalyzed Coupling of Terminal Alkynes and N‐Tosylhydrazones Derived from O‐Formyl Biphenyls.
Authors: Ye Fei , Shi Yi , Zhou Lei , Xiao Qing , Zhang Yan , Wang Jianbo
Published: January 2012

The reaction does not require any ligands and proceeds via coupling/cyclization of terminal alkynes and N‐tosylhydrazones.
ChemInform Abstract: A Powerful Cascade Approach for Expeditious Synthesis of Trifluoromethylated Furans.
Authors: Wang Yao , Luo Yong‐Chun , Hu Xiu‐Qin , Xu Peng‐Fei
Published: January 2012

Tetra‐substituted furan derivatives are prepared with excellent yields from α,β‐unsaturated ketoesters and TFAA.
ChemInform Abstract: Organocatalytic Asymmetric Henry Reaction of Isatins: Highly Enantioselective Synthesis of 3‐Hydroxy‐2‐oxindoles.
Authors: Zhang Yong , Li Zhi Jun , Xu Hai Sen , Zhang Yuan , Wang Wei
Published: January 2012

The methodology is also applied as the key step for the total synthesis of (R)‐dioxibrassinin (IV) and the formal synthesis of (S)‐spirobrassinin (V).
ChemInform Abstract: Novel Indole and Azaindole (Pyrrolopyridine) Cannabinoid (CB) Receptor Agonists: Design, Synthesis, Structure—Activity Relationships, Physicochemical Properties and Biological Activity.
Authors: Blaazer Antoni R. , Lange Jos H. M. , van der Neut Martina A. W. , Mulder Arie , den Boon Femke S. , Werkman Taco R. , Kruse Chris G. , Wadman Wytse J.
Published: January 2012

The discovery, synthesis, and SAR of a novel series of cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptor ligands are reported.
ChemInform Abstract: Heterogeneous Catalytic Hydrogenation of Unprotected Indoles in Water: A Green Solution to a Long‐Standing Challenge.
Authors: Kulkarni Aditya , Zhou Weihong , Toeroek Bela
Published: January 2012

The reaction is applied to a wide range of substituted indoles under moderate hydrogen pressure.
ChemInform Abstract: Dehydrogenative Diels—Alder Reaction.
Authors: Ozawa Takuya , Kurahashi Takuya , Matsubara Seijiro
Published: January 2012

The intramolecular reaction includes a styrene moiety as diene and an alkyne moiety as dienophile.
ChemInform Abstract: Phosphine‐Initiated General Base Catalysis: Facile Access to Benzannulated 1,3‐Diheteroatom Five‐Membered Rings via Double‐Michael Reactions of Allenes.
Authors: Szeto Judy , Sriramurthy Vardhineedi , Kwon Ohyun
Published: January 2012

The reaction succeeds also with DMAP as basic catalyst, but mostly with lower yields.
ChemInform Abstract: Silica Chloride Catalyzed One‐Pot Synthesis of Fully Substituted Pyrazoles.
Authors: Jawale Dhanaji V. , Pratap Umesh R. , Mali Jyotirling R. , Mane Ramrao A.
Published: January 2012

The protocol avoids highly toxic reagents and is suitable for the synthesis of libraries.
ChemInform Abstract: Sulfuric Acid {[3‐(3‐Silicapropyl)sulfanyl]propyl}ester, a Recyclable Catalyst for the Synthesis of 2‐Aryl‐1‐arylmethyl‐1H‐1,3‐benzimidazole Derivatives.
Authors: Iravani Nasir , Mohammadzade Negar Safikhani , Niknam Khodabakhsh
Published: January 2012

The process works well with aromatic aldehydes, whereas alkyl aldehydes and cyclohexanone do not react.
ChemInform Abstract: One‐Pot Tandem Approach for the Synthesis of Benzimidazoles and Benzothiazoles from Alcohols.
Authors: Raghavendra Goravanahalli M. , Ramesha Ajjahalli B. , Revanna Cigalli N. , Nandeesh Kebbahalli N. , Mantelingu Kempegowda , Rangappa Kanchugarakoppal S.
Published: January 2012

T3P is an efficient and mild reagent which allows the direct use of alcohols in the process without the need for an additional oxidant.
ChemInform Abstract: Oxazolidine Synthesis by Complementary Stereospecific and Stereoconvergent Methods.
Authors: Shaghafi Michael B. , Grote Robin E. , Jarvo Elizabeth R.
Published: January 2012

The stereospecific reaction applies a chiral epoxide (I) and racemic catalyst to afford the chiral oxazolidine derivatives (III).
ChemInform Abstract: Catalytic Asymmetric Synthesis of Isoxazoline‐N‐oxides Through Conjugate Addition—Cyclization under Phase‐Transfer Conditions.
Authors: Kano Taichi , Yamamoto Akihiro , Song Sunhwa , Maruoka Keiji
Published: January 2012

The application of a chiral phase‐transfer catalyst gives the isoxazoline‐N‐oxide products (III)/(V) with moderate to good yields and enantioselectivity.
ChemInform Abstract: Synthesis of Novel Spiro(indolone‐3,2′‐[1,3,4]thiadiazol)‐2‐ones and Evaluation of Their Antidepressant and Anticonvulsant Activities.
Authors: Hassan Alaa A. , Abdel‐Latif Fathy F. , El‐Din Ahmed M. Nour , Abdel‐Aziz Mohamed , Mostafa Sara M. , Braese Stefan
Published: January 2012

The compounds (III) exhibit remarkable antidepressant activity compared with imipramine and compared with phenobarbital they show a good protection against clonic seizures induced by ip injection of pentylenetetrazol in mice (no yields given).
ChemInform Abstract: Microwave‐Assisted Synthesis of Tetrazolyl Pyrazole Amides.
Authors: Hu Jun , Wang Jikui , Zhou Taoyu , Xu Yanhua
Published: January 2012

The title compounds (III) (6 examples) are found to exhibit interesting bacteriocidal, pesticidal, herbicidal and antimicrobial activities.
ChemInform Abstract: A Novel One Pot Route to Flavones under Dual Catalysis, an Organo‐ and a Lewis Acid Catalyst.
Authors: Maiti Gourhari , Karmakar Rajiv , Bhattacharya Rudraksha N. , Kayal Utpal
Published: January 2012

Air can be used as the stoichiometric oxidant in the presence of ecofriendly FeCl3.The products, which represent structures of insecticidal agents, are easily isolated.