bluuebunny/crossref_metadata_2025 huggingface dataset:
Conditional generative models for sampling and phase transition indication in spin systems
Authors: Singh Japneet , Scheurer Mathias , Arora Vipul
Published: August 2021

In this work, we study generative adversarial networks (GANs) as a tool to learn the distribution of spin configurations and to generate samples, conditioned on external tuning parameters or other quantities associated with individual configurations. For concreteness, we focus on two examples of conditional variables---the temperature of the system and the energy of the samples. We show that temperature-conditioned models can not only be used to generate samples across thermal phase transitions, but also be employed as unsupervised indicators of transitions. To this end, we introduce a GAN-fidelity measure that captures the model’s susceptibility to external changes of parameters. The proposed energy-conditioned models are integrated with Monte Carlo simulations to perform over-relaxation steps, which break the Markov chain and reduce auto-correlations. We propose ways of efficiently representing the physical states in our network architectures, e.g., by exploiting symmetries, and to minimize the correlations between generated samples. A detailed evaluation, using the two-dimensional XY model as an example, shows that these incorporations bring in considerable improvements over standard machine-learning approaches. We further study the performance of our architectures when no training data is provided near the critical region.
Rank $Q$ E-string on spheres with flux
Authors: Hwang Chiung , Razamat Shlomo , Sabag Evyatar , Sacchi Matteo
Published: August 2021

We consider compactifications of rank \boldsymbol{Q}𝐐
E-string theory on a genus zero surface with no punctures but with flux
for various subgroups of the \boldsymbol{\mathrm{E}_8\times \mathrm{SU}(2)}E8×SU(2)
global symmetry group of the six dimensional theory. We first construct
a simple Wess–Zumino model in four dimensions corresponding to the
compactification on a sphere with one puncture and a particular value of
flux, the cap model. Using this theory and theories corresponding to two
punctured spheres with flux, one can obtain a large number of models
corresponding to spheres with a variety of fluxes. These models exhibit
interesting IR enhancements of global symmetry as well as duality
properties. As an example we will show that constructing sphere models
associated to specific fluxes related by an action of the Weyl group of
\boldsymbol{\mathrm{E}_8}E8
leads to the S-confinement duality of the \boldsymbol{\mathrm{USp}(2Q)}USp(2𝐐)
gauge theory with six fundamentals and a traceless antisymmetric field.
Finally, we show that the theories we discuss possess an
\boldsymbol{\mathrm{SU}(2)_{\text{ISO}}}SU(2)ISO
symmetry in four dimensions that can be naturally identified with the
isometry of the two-sphere. We give evidence in favor of this
identification by computing the `t Hooft anomalies of the
\boldsymbol{\mathrm{SU}(2)_{\text{ISO}}}SU(2)ISO
in 4d and comparing them with the predicted anomalies from 6d.
SERBIAN ADAPTATION OF THE PSYCHOLOGICAL MINDEDNESS SCALE - PSYCHOLOGY STUDENTS SAMPLE
Authors:   Department of Social Policy and Social Work, Faculty of Philosophy, University of Nis, Republic of Serbia, Anđelković Ivan
Published: August 2021

The purpose of this research was to evaluate the quality criteria and the factor structure of the Serbian translation of the Psychological Mindedness Scale (PMS) (Shill and Lumley, 2002). In this paper we offer the detailed description of the translation and validation procedures we fallowed. Psychological Mindedness outlines the interest as well as the ability of an individual to introspectively reflect on emotions and conflicts. The sample consisted of 166 university students. Results indicate good psychometric propperties. Internal consitancy is good. Explorative factor analysis suggested that a four factor solution is better that the original five factor, because of fewer cross-loadings and better content validity of the factors. Good convergent validity was demonstrated by a strong negative correlation between the whole PMS, and all four factors separately, and Toronto Alexithymia Scale (TAS-20). Perspectives for further improvement of the instrument and its application in therapeutic process are discussed in the conclusion.
LONELINESS OF HIGH SCHOOL AND COLLEGE STUDENTS: THE RELATION OF SOCIO-DEMOGRAPHIC CHARACTERISTICS AND SELF-ESTEEM WITH LONELINESS
Authors:   Psychology Department, Faculty of Philosophy, University of East Sarajevo, Bosnia and Herzegovina, Kostić Nataša , Solaković Šuajb ,   Psychology Department, Faculty of Philosophy, University of East Sarajevo, Bosnia and Herzegovina
Published: August 2021

The research problem relates to the examination of the relationof socio-demographic characteristics (gender, level of education and the place where most of childhood was spent) and the self-esteem of the respondents with loneliness.In investigating this problem, the focus was primarily on the perception of the distribution of loneliness, and the examination of the relation of independent variables (socio-demographic characteristics and self-esteem) with the dependent variable (loneliness).The sample of respondents consists of 677 high school students (49.34%) and college students (50.66%) of Bosnia and Herzegovina. The range of years of subjects ranges from 15 to 23 (AS = 18.696).The results of the study show that there is a statistically significant difference in loneliness with regard to gender (U = 38672.000, Z = -6.122, p = .000), to the level of education (U = 42292.500, Z = -5.905, p = .000) and the place in which the respondents spent most of their childhood (χ2 = 9.383, df = 2, sig = .009). The results show that there is a statistically significant relation between self-esteem and loneliness (ro = -.401, sig = .000, N = 676).
THE INFLUNECE OF 4G/5G POLYMORPHISM OF ACTIVATOR INHIBITOR PLASMINOGEN 1 GENE (PAI-1) ON DEVELOPEMENT DEEP VEIN THROMBOSIS
Authors:   Biology Department, Faculty of Natural Sciences and Mathematics, University of Tuzla, Bosnia and Herzegovina, Pođanin Maja , Terzić Rifet ,   Biology Department, Faculty of Natural Sciences and Mathematics, University of Tuzla, Bosnia and Herzegovina, Avdić Aldijana ,   Biology Department, Faculty of Natural Sciences and Mathematics, University of Tuzla, Bosnia and Herzegovina, Jusić Amela ,   Biology Department, Faculty of Natural Sciences and Mathematics, University of Tuzla, Bosnia and Herzegovina
Published: August 2021

Analysis of 4G/5G polymorphisms of PAI-1 gene in interaction with other genetic and external risk factors that induce development of venous thromboembolism can be used for risk assessment for development of venous thromboembolism. Research was conducted on 202 examinees of both genders, older than 18, from north-eastern Bosnia. Experimental group included 100 examinees with diagnosed DVT and 101 examinees who until the sampling procedure did not have diagnosed DVT. In DVT group, following genotype frequencies were determined: 27% of examinees had a normal genotype 5G/5G, 68% are heterozygotes and 5% are mutated homozygotes 4G/4G. In the control group, frequencies of 4G/5G polymorphisms of PAI-1 gene were: 42.6% of examinees have 5G/5G genotype, 55.4% are heterozygotes 4G/5G and 2% are 4G/4G genotype. Obtained results support the hypothesis that PAI-1 in interaction with other genetic and external risk factors probably induces the development of venous thromboembolism.
LEADING DISEASES IN DENTAL PROTECTION OF CHILDREN AND YOUTH IN HERZEGOVINA-NERETVA CANTON IN 2008 AND 2013
Authors:   Doboj Istok Health Center, Doboj Istok, Bosnia and Herzegovina, Suljkanovic Nermin , Balic Dzenan ,   Mostar Health Center, Mostar, Bosnia and Herzegovina, Begic Nadina ,   Doboj Istok Health Center, Doboj Istok, Bosnia and Herzegovina
Published: August 2021

The purpose of this paper is to detect the leading diseases diagnosed in dental care, for the population 0-6 years and 07-18 years of age for the Herzegovina-Neretva Canton in 2008 and 2013, to compare the results for those two years, to determine trends, individual diseases, and comparing the obtained results with the results for the territory of the Federation of B&H. During the preparation of this paper, the data collected and published in its reports by the Institute of Public Health of the Federation of Bosnia and Herzegovina were used. Dental caries / K02 / takes the first place on the list of diseases in the field of dental activity, in all age groups. Diseases of the pulp and periapical tissue / K04 /, which most often occur as a result of caries, take second place on the list of diseases in all age groups. It is necessary to work on increasing the number of public healthcare of specialist teams of preventive and pediatric dentistry in the area of HNK, as well as increasing the number of dental care points, where children and youth would receive the service. Further work is needed to improve the state of oral health and the population through.
MODELLING VOLATILITY SPILLOVER BETWEEN CONVENTIONAL AND ISLAMIC STOCK INDEX IN MALAYSIA
Authors:   Cantonal Administration for Inspection Affairs of Tuzla canton, Bosnia and Herzegovina, Djedović Edin , Ergun Ugur ,   Epoka University, Albania, Djedović Irfan ,   International Burch University, Bosnia and Herzegovina
Published: August 2021

This paper analyzes the vollatility spillover between the conventional index in Malaysia FTSE Malaysia KLCI (KLSE) and the Islamic index in Malaysia FTSE Bursa Malaysia Shariah Index (FTFBMHS). Monthly observations spanning in a period from 2002 to 2018 are obtained from investing.com database. GARCH model and Johansen cointegration test are used to investigate volatility spillover and the relationship between two indices. The results of the analysis indicate that in the short-run there is volatility spillover between FTSE Malaysia KLCI and FTSE Bursa Malaysia Shariah Index, while in the long-run there is no relationship between the two indices. The methodology of compiling Islamic indeces is based on Shariah law. Keywords: Conventional
Companies’ competitiveness in the context of food embargo: Brand orientation of Russian food producers
Authors:   Graduate School of Business, National Research University Higher School of Economics, Kusraeva Olga A. , Rebiazina Vera A. ,   Graduate School of Business, National Research University Higher School of Economics
Published: August 2021

In this paper, based on an empirical study of 198 Russian companies-food producers, an attempt is made to identify the features of brand orientation realization in the context of the food embargo. The data was collected using a questionnaire based on a brand orientation scale, developed under the circumstances of the Russian market features. The data collected are analyzed using hierarchical and non-hierarchical cluster analysis. As a result of the cluster analysis, a typology of Russian companies-food producers is formed, four clusters are identified, differing in the level of brand orientation and the specifics of brand management activities: 1. high brand orientation, 2. medium brand orientation focused on communication, 3. low brand orientation focused on research, 4. no brand orientation. Each cluster is described by eight parameters that reflect the characteristics of brand management: the focus of the company's brand management activities, brand identity, employees, positioning, brand values, communications, visual identification, and performance evaluation. For each cluster, the features and limitations are identified, which determines the behavior of the companies in the Russian market. The article also defines the marketing features of the Russian food market caused by the introduction of the food embargo, reveals a change in the structure of foreign food suppliers to Russia, as well as a change in the level of competition among companies operating in the Russian market. In addition, the results of the cluster analysis were compared with the data of the TGI Marketing Index, which revealed the correlation between the indicators of brand effectiveness and the level of brand orientation implementation.
Program aniconism in theology of Devarim (Deuteronomy)
Authors:   St. Petersburg State Pediatric Medical University, Raevskaya Natalya Yu.
Published: August 2021

The article explores the formation of the aniconic position in ancient Judaism. A reference to biblical texts shows that the aniconic doctrine, which put forward the demand for a cult without an image was formulated and theologically substantiated in the book of Devarim. Here, the prohibition on creating images follows YHWH’s statement of formlessness and is seen as its logical consequence. The invisible God cannot be adequately embodied in a visual material image and does not need it, because he has a different way of interacting with his people. Deities of other nations manifest themselves in temple statues, providing their worshipers the opportunity to approach them through a cult, but the God of the Jews, in accordance with the Devarim doctrine, chose a different way of communicating with people. He does not need statues, he remains with the people mainly not because of the correctness of the ritual, but because of the carefully executed law (only a small part of which is the ritual). In fact, in Devarim the scheme is reversed compared to the usual view of things at that time. The creation of images and worship of them does not bring the deity closer to people, but on the contrary threatens him with a distance. Comparison with the statements regarding the images in the book of Shemot (Exodus) suggests the following: a consistent aniconic program corresponding to clearly articulated monotheism and a specific cult paradigm was first announced in Devarim, and began to be established in the Jewish environment, probably not earlier than the end of VII c. BC.The religion of the ancient Jews was not static, strict aniconism was not inherent in Judaism initially, but it took shape and developed over many centuries.
Veneration of saints in Anglicanism
Authors:   Togliatti State University, Dementyev Leonid I.
Published: August 2021

The Anglican Communion, which unites forty-one local Anglican Churches, traditionally honors holy ascetics and heroes of the faith, among whom there are both saints glorified after the English Reformation and general Christian teachers and martyrs known to the Roman and Eastern Orthodox Churches. Some Anglicans honor the saints, turning to the One God with gratitude for certain examples of a great righteous life, and ask Christ to send down the same good deed. Other Anglicans, on the contrary, appeal to the saint directly, like Catholics and Orthodox Christians. By themselves, Anglican views are very specific and strongly dependent on a particular church movement (there are “parties” of Anglo-Catholics, Anglo-Orthodox, Anglo-Evangelicals, etc., who have their own opinions on this issue), however, among the Orthodox there is a common misconception that being a Protestant means unequivocally rejecting the cult of saints. In this article, the author reveals in detail to the Russian reader the peculiarity of the Anglican practice of veneration of saints and provides examples of the presence of prayer appeals to saints in modern Anglican practice, dispelling the popular misconception about the lack of veneration of saints and appeals to saints in the Protestant world.
Future virtual water flows under climate and population change scenarios: focusing on its determinants
Authors: Ashktorab Niloofar , Zibaei Mansour
Published: August 2021

Water resources are under increasing pressure from population growth, socio-economic development, and climate change. The main user of freshwater is the agriculture sector, accounting for 70–80% of global water use. Consequently, increasing water productivity and reducing water use in this sector are vital for alleviating water scarcity. It has been alleged that domestic or international trade of water-consumed products from wet-provinces or countries to arid and semi-arid provinces or countries is one possible path to mitigate water shortage. In this regard, virtual water flows and their determinants in Iran are investigated in this paper. This study examines the main determinants of bilateral virtual water flows associated with international trade in agricultural goods among Iran and other countries using a gravity model of trade. The impacts of climate change and socio-economic change scenarios on the virtual water trade are simulated. The result of the gravity model indicated that bilateral virtual water trade flows are influenced by the classical determinants and all the mass-related variables (gross domestic product and population) are significant with expected signs. Finally, the result obtained from the simulation of climate and socio-economic change scenarios showed that under the pessimistic scenario of climate change and population growth rate of 0.98 and 0.44%, VW trade between Iran and other countries would increase by 41 and 66% in the periods of 2016–2045 and 2070–2099, respectively. As a consequence, identifying the appropriate countries for business interactions and adopting effective trade policies are very important and need attention soon.
Research on the spatial effect and threshold effect of industrial structure upgrading on carbon emissions in China
Authors: Li Zhenqiang , Zhou Qiuyang
Published: August 2021

Based on panel data from 2000 to 2017 in 29 Chinese provinces, this paper analyzes the impact of industrial structure upgrading on carbon emissions by constructing a spatial panel model and a panel threshold model. The results show that (1) there is a significant spatial correlation between carbon emissions in Chinese provinces, and the carbon emissions of a province are affected by the carbon emissions of surrounding provinces; (2) in China, carbon emissions have a significant time lag feature, and current carbon emissions are largely affected by previous carbon emissions; (3) industrial structure upgrading can effectively promote carbon emission reductions in local areas, and the impact of industrial structure upgrading on carbon emissions has a significant threshold effect. With continued economic development, the promotion effect of industrial structure upgrading on carbon emission reductions will decrease slightly, but this carbon emission reduction effect is still significant. (4) In addition, there is a clear difference between the impact of energy consumption intensity and population size on carbon emissions in short and long terms. In the short term, the increase in energy consumption intensity and the expansion of population size not only increase the carbon emissions of a local area but also increase the carbon emissions of neighboring areas. In the long term, the impact of energy consumption intensity and population size on carbon emissions of neighboring areas will be weakened, but the promotion impact on carbon emissions in local areas will be strengthened.
Hungary in journalism of Roman Dmowski (based on „Polish Politics and the Rebuilding of the State”)
Authors: Kowalczyk Michał
Published: August 2021

Roman Dmowski was a Polish politician and an ideological father of National Democracy. He was a very important figure for the restoration of Poland’s independence after the First World War. In 1925 he published his famous book entitled “Polish Politics and the Rebuilding of the State”. He explained his motives for an anti-German policy before and during the First World War. This article is focused on his relations with Hungary. Despite the tradition of Polish-Hungarian friendship, Roman Dmowski represented a rather unfriendly position towards Hungary considering policy of Budapest as favorable to Germany. Therefore, Roman Dmowski was a follower of an alliance with Prague and Bucharest instead
The Concordantia of the three great sacramentaries: Gregorian, Veronese and Gelasian
Authors: Sodi Manlio , Baroffio Giacomo , Toniolo Alessandro
Published: August 2021

The “tradition” of the Church never ceases to amaze us with its wealth and the characteristics of its documents. The liturgical tradition contributes to this in an important way as well. Finding the appropriate tools to learn about these documents is of great importance. In this way, the great work done by the three scholars of liturgy is a beacon and an appeal. Looking through all of the texts reveals the infinity of elements which, without any shadow doubt, can be a great help per philolgiam ad theologia or ad culturam!
Characteristics of the archival fond of „Konvento Polonia aktai” from the Wróblewski Library of the Lithuanian Academy of Sciences
Authors: Dowgiało Karol
Published: August 2021

After World War II documentation of archive of the Konwent Polonia was dispersed. Currently, it is gathered in three institutions: The Archdiocesan Archive of Warsaw, The Wro-blewski Library of the Lithuanian Academy of Sciences in Vilnius and The Polish Institute and Sikorski Museum in London. This study presents a Vilnius collection – both structure of the archival fond and the information value of gathered archival units. It is extremely useful for researchers – particularly in the context of the lack of online inventories, as well as factual mistakes committed during the archival description of the records gathered there.

This archival fond consists of 404 units and it is one of the most important sources for the history of both the Konwent Polonia and polish fraternities. Especially that most of fraternities archives were destroyed, and the total number of members of all academic fraternities until the outbreak of World War II was at least over a twelve thousand
The echoes of the outside world events on the pages of the Chronicle of Zofia Grothówna in years 1703-1741
Authors: Mierzejewska Milena
Published: August 2021

The article describes the echoes of the events from the outside world in an enclosed Norbertine convent in Imbramowice and is mainly based on the records taken from The Chronicle of Sophia Grothówna from the years 1703-1741. Although the Norbertine monastery was (and still is) enclosed, it maintained communications with the outside world on a regular basis but unwillingly. This article discusses just such situations. Sisters had to contend with numerous military invasions, requesting ever larger contributions and looting the surroundings belonging to the nuns’ granges. During the wars of the seventeenth century a number of epidemics broke out, which reached the surrounding areas in Imbarmowice. The peasants contracted the plague from the army. Other events included the outbreak of fires, the largest of which broke out in 1704 and as a result many sisters had to leave the monastery and move to other monasteries or return to their homes. The reconstruction of the monastery took almost 20 years. The article describes information about the floods, strong gales, hunger, cold and drought that ravaged the monastery and caused major damage in the convent farms.
The castle in Podhorce in the years 1865 -1939. The state of research and the research postulates
Authors: Paduch Katarzyna
Published: August 2021

The Castle in Podhorce has been, and remains, the subject of many studies and articles, but not all aspects of the history of this residence have been studied. This paper presents the state of research on the history of the Castle in Podhorce in the years 1865-1939. The period of ownership of the palace by Princess Constance of Zamoyskich Sanguszko (1864-1946) and Stanislaw Eustachy Sanguszko (1842-1903) still is to be researched. For researchers of the history of the residence in Podhorce the most difficult challenges are related to the detailed examination of the source documents presenting fortunes of the palace against the background of important historical events. In the years 1865-1939 turning points for the Castle in Podhorce were: World War I, the War of 1920, the commemoration of the 250th anniversary of the Battle of Vienna and the outbreak of World War II. However the administration and care of goods in Podhorce is the issue least studied.
Care for the sick in ancient monasteries in the light of selected monastic rules
Authors: Kołosowski Tadeusz
Published: August 2021

This article attempts to answer the question of how Eastern and Western monastic rules provided for the sick in ancient monasteries. Did they enjoy any kind of special status among their brothers or sisters? Who was responsible for the sick in the monastery and how they took care of the ill? In this regard, monastic rules are an interesting and unique source of information about activities undertaken to care for ill members of the monastic community. We identified and analysed seven monastic rules. These rules were written in different regions of the contemporary world: Egypt, North Africa, Gaul, Italy, and Spain. One was written in the 4th, and the other in the 7th century, and both concern monks and consecrated women. Each rule appoints some individuals responsible for the care of the sick. These were usually nurses and monastic dispensers. Some rules determined the required personality traits. The general supervision over the care of the sick was entrusted to the monastery superior. Separate rooms or cells were designated for the sick, sometimes together with a dining room, pantry, or kitchen. All the rules seek to ease the requirements concerning the consumption of meals, fasts, and hygiene for the sick. If capable, they should engage in lighter works.
The Foundation of the Qubbat as-Sakhrah Sanctuary as an expression of Abd-al Malik Ibn Marwan’s piety and/or political premises
Authors: Nowogórski Przemysław
Published: August 2021

At the end of the seventh century, Caliph Abd al-Malik ibn Marwan built the Qubbat as-Sakhrah sanctuary on the Temple Mount in Jerusalem. It is difficult to explain the reasons for the foundation of the sanctuary. The caliph may have wanted to make it an alternative destination for the Hajj, as Mecca was under the occupation of Anti-caliph Ibn al-Zubayr. Another reason may have been tied to the caliph’s desire to commemorate Prophet Muhammad’s Night Journey. The surviving written records fail to provide an unambiguous explanation of either of these hypotheses. The location, architecture, and decoration of the Dome of the Rock suggest that the Caliph built a magnificent monument for the greater power and glory of Islam.
The chapels of Saint Casimir and the Immaculate Conception at the Vilnius Cathedral in the eyes of Discalced Carmelite nuns: An unrecognized source from 1638
Authors: Czyż Anna Sylwia
Published: August 2021

The article recalls a source from 1638 which has hitherto not been referred to in the literature on the subject, i.e. the history of two chapels at the cathedral in Vilnius: the Chapel of St. Casimir founded by King Sigismund III, and the Chapel of the Immaculate Conception, furnished as a burial chapel by Bishop Eustachy Wołłowicz (lit. Eustachijus Valavičius). The said source is a diary written by a Carmelite nun during her journey from Lublin to Vilnius (14 November – 26 December 1638), which she made with three fellow nuns assigned to a new monastery founded by Stefan Pac (lit. Steponas Pacas) and his wife Anna Maria Ancilia née Rudomina-Dusiatska (lit. Ona Marija Ancilia Rudomina-Dusiackaitė). The diary was penned by Sister Mary Magdalene (Anna Żaboklicka) who described various aspects of their journey, as well as a visit to the Vilnius Cathedral organized by the Pac family. The nuns were particularly impressed by the Chapel of St. Casimir. Thanks to Sister Mary Magdalene’s detailed description of the chapel, it was possible to reconstruct the subjects of some paintings by Bartłomiej Strobel, and to interpret several facets of its appearance, including the feretory of St. Casimir. While the description of Bishop Eustachy Wołłowicz’s chapel is not as detailed, it should be stressed that by inviting the nuns there, the Pac family intended to emphasize their kinship with the ruler of Vilnius, who was highly esteemed by his contemporaries.
Extraordinary events, disasters and marching armies in greater Poland in the 17th and 18th centuries and their impact on the life of nuns in the Benedictine monastery as reflected in the monastic Chronicle
Authors: Lewandowska Ada
Published: August 2021

The Benedictine Monastery in Poznań was founded in 1607 by Magdalena Mortęska, the reformer of the religious order. By analysing the monastic chronicles, the author wanted to show the influence of extra-ordinary events in Greater Poland and Poznań in the 17th and 18th centuries on the life of enclosed nuns. The article describes what changed when people visited the monastery, what life of nuns looked like during epidemics, floods and other disasters that took place in Greater Poland. The article moreover probes the influence of wars and the presence of foreign armies in the city of Poznań on the life of the Benedictine nuns.
Relacionamentos abusivos: A dor do amor no distanciamento social
Authors: Matos de Souza Anna Claudia , Cabral Samico Fernanda
Published: August 2021

O presente trabalho busca entender como se institui um relacionamento abusivo, e se propõe a problematizar o porquê de as mulheres serem as principais vítimas desta modalidade de relacionamento. Utilizando-se de alguns conceitos freudianos e lacanianos foi construído através de uma revisão bibliográfica uma teorização sobre o conceito de feminilidade, além de uma reflexão acerca da devastação que atravessa estes relacionamentos disfuncionais. Por fim, procuramos entender como a pandemia causada pela COVID-19, bem como o distanciamento social, influenciou nas crescentes denúncias acerca das violências vividas em um relacionamento abusivo. Entende-se então, que o sujeito regido pelo inconsciente busca tão somente a completude daquilo que falta, e ainda, que o Real que a pandemia trouxe a estas mulheres, corrobora com o aumento repentino das denúncias dos casos de violência doméstica que não foram meramente um acaso, mas a ocorrência da quebra da fantasia em que ela vivia, fazendo com que o gozo proporcionado pelo sintoma não funcione mais.

Palavras chaves: Feminilidade; Devastação; Pandemia; Relacionamento abusivo.
Aumento da Síndrome de Burnout na pandemia nos profissionais em geral
Authors: Carvalho de Oliveira Larissa , Nascimento Araújo Dara , Vasconcelos da Silva Bernardino Adriana , Niemeyer da Rocha Fátima
Published: August 2021

As situações de trabalho provenientes das emergências sanitária, econômica e social enfrentadas pela maioria dos profissionais brasileiros atrelados ao distanciamento social e ao enclausuramento, promovem um acréscimo da Síndrome de Burnout, pois com o avanço da COVID-19 todos os profissionais são afetados pelo impacto psicológico, entendendo-se assim, que a população é comprometida em maior ou menor grau, como notado em outras pandemias. Ao se constatar que o distanciamento ou isolamento social representou um acréscimo na incidência da síndrome de Burnout, revelou-se um grande desafio para a saúde mental. Justifica-se o presente estudo pelos impactos sofridos na população pelo COVID-19, que apresentados pelo viés psicológico do ser humano afetam o bem-estar dos profissionais, causando distúbios mentais, englobando o aumento da síndrome de Burnout pois as pandemias infecciosas fazem aumentar os níveis de estresse e de insegurança. O objetivo do artigo é destacar a influencia da COVID-19 no aumento da Síndrome de Burnout nos vários tipos de profissionais e na população de um modo geral. Trata-se de uma revisão bibliográfica pesquisada nas bases de dados de vinculação livre. Conclui-se que diante de um cenário econômico incerto de uma pandemia, do acréscimo de competitividade e da procura por uma posição no ambiente profissional, pode-se revelar um esgotamento psicológico promovendo angústia, desesperança e a síndrome de Burnout.
Identification of WHO II/III Gliomas by 16 Prognostic-related Gene Signatures using Machine Learning Methods
Authors: Wu Ya Meng , Sa Yu , Guo Yu , Li Qi Feng , Zhang Ning
Published: August 2021

Background:

It is found that the prognosis of gliomas of the same grade has
large differences among World Health Organization (WHO) grade II and III in clinical
observation. Therefore, a better understanding of the genetics and molecular mechanisms
underlying WHO grade II and III gliomas is required, with the aim of developing a classification
scheme at the molecular level rather than the conventional pathological morphology
level.

Method:

We performed survival analysis combined with machine learning methods of
Least Absolute Shrinkage and Selection Operator using expression datasets downloaded
from the Chinese Glioma Genome Atlas as well as The Cancer Genome Atlas. Risk
scores were calculated by the product of expression level of overall survival-related genes
and their multivariate Cox proportional hazards regression coefficients. WHO grade II
and III gliomas were categorized into the low-risk subgroup, medium-risk subgroup, and
high-risk subgroup. We used the 16 prognostic-related genes as input features to build a
classification model based on prognosis using a fully connected neural network. Gene
function annotations were also performed.

Results:

The 16 genes (AKNAD1, C7orf13, CDK20, CHRFAM7A, CHRNA1, EFNB1,
GAS1, HIST2H2BE, KCNK3, KLHL4, LRRK2, NXPH3, PIGZ, SAMD5, ERINC2, and
SIX6) related to the glioma prognosis were screened. The 16 selected genes were associated
with the development of gliomas and carcinogenesis. The accuracy of an external
validation data set of the fully connected neural network model from the two cohorts
reached 95.5%. Our method has good potential capability in classifying WHO grade II
and III gliomas into low-risk, medium-risk, and high-risk subgroups. The subgroups
showed significant (P<0.01) differences in overall survival.

Conclusion:

This resulted in the identification of 16 genes that were related to the prognosis
of gliomas. Here we developed a computational method to discriminate WHO grade
II and III gliomas into three subgroups with distinct prognoses. The gene expressionbased
method provides a reliable alternative to determine the prognosis of gliomas.
Interaction of Exogenous Butyrylcholinesterase with β-Amyloid Plaques in 5XFAD/Butyrylcholinesterase-Knockout Mouse Brain
Authors: Reid G.A. , Darvesh S.
Published: August 2021

Background:

In Alzheimer’s disease (AD), and amyloid models such as the 5XFAD
mouse, butyrylcholinesterase (BChE) is associated with β-amyloid (Aβ) plaques and has unique
biochemical features which distinguish it from that found in neurons. It has been suggested that
BChE associated with Aβ plaques may be involved in the maturation of this structure and thus disease
progression.

Objective:

Currently, it is unknown whether BChE bound to Aβ plaques has altered biochemical
properties due to a different primary structure or because of the association of this enzyme with Aβ
plaques. Also, the source and binding mechanism of this BChE remains unknown.

Methods:

Brain tissue sections from the 5XFAD/BChE-KO mouse were incubated with exogenous
sources of BChE and stained for this enzyme’s activity. Efforts were made to determine what region
of BChE or Aβ may be involved in this association.

Results:

We found that incubation of 5XFAD/BChE-KO brain tissues with exogenous BChE led to
this enzyme becoming associated with Aβ plaques and neurons. In contrast to neuronal BChE, the
BChE bound to Aβ plaques had similar biochemical properties to those seen in AD. Mutations to
BChE and efforts to block Aβ epitomes failed to prevent this association.

Conclusion:

The association of BChE with Aβ plaques, and the resultant biochemical changes,
suggests that BChE may undergo a conformational change when bound to Aβ plaques but not neurons.
The 5XFAD/BChE-KO model is ideally suited to explore the binding mechanism of BChE to
Aβ plaques as well as the involvement of BChE in AD pathogenesis.
Gender Differences in the Risk of Adverse Outcomes After Incident Diabetic
Foot Hospitalization: A Population Cohort Study
Authors: Seghieri Giuseppe , Policardo Laura , Gualdani Elisa , Francesconi Paolo
Published: August 2021

Background:

Diabetic Foot Disease (DFD) is more prevalent among males and is associated
with an excess risk of cardiovascular events or mortality.

Aims:

This study aimed at exploring the risk of cardiovascular events, renal failure, and all-cause
mortality after incident DFD hospitalizations, separately in males and females, to detect any gender
difference in a cohort of 322,140 people with diabetes retrospectively followed up through administrative
data sources in Tuscany, Italy, over the years 2011-2018.

Methods:

The Hazard Ratio (HR) for incident adverse outcomes after first hospitalizations for
DFD, categorized as major/minor amputations (No.=449;3.89%), lower limbs’ revascularizations
(LLR: No.=2854;24.75%), and lower-extremity-arterial-disease (LEAD) with no procedures
(LEAD-no proc: No.=6282;54.49%), was compared to the risk of patients having a background of
DFD (ulcers, infections, Charcot-neuroarthropathy: No.=1,944;16.86%).

Results:

DFD incidence rate was higher among males compared to females (1.57(95%
CI:1.54-1.61) vs. 0.97(0.94-1.00)/100,000p-years]. After DFD, the overall risk of coronary artery
disease was significantly associated with the male gender and of stroke with the female gender.
LEAD-no proc and LLR were associated with the risk of stroke only in females, whereas they were
found to be associated with the risk of coronary artery disease among females to a significantly
greater extent compared to males. The incident of renal failure was not associated with any DFD
category. Amputations and LEAD-no proc significantly predicted high mortality risk only in females,
while LLR showed reduced risk in both genders. Moreover, females had a greater risk of
composite outcomes (death or cardiovascular events). Compared to the background of DFD, the
risk was found to be 34% higher after amputations (HR: 1.34(1.04-1.72)) and 10% higher after
LEAD-no proc (HR:1.10(1.03-1.18)), confirming that after incident DFD associated with vascular
pathogenesis, females are at an increased risk of adverse events.

Conclusions:

After incident DFD hospitalizations, females with DFD associated with amputations
or arterial disease are at a greater risk of subsequent adverse cardiovascular events than those with
a DFD background.
Cardiovascular Autonomic Reflex Tests and 7 Heart Rate Variability Indices for Early Diagnosis of Cardiovascular Autonomic Neuropathy in Type 2 Diabetes Individuals
Authors: Atala Yeelen Ballesteros , De Matos Mozânia Reis , Correa-Giannella Maria Lucia , Ribeiro Parisi Maria Cândida , Zantut-Wittmann Denise Engelbrecht , Castillo Alejandro Rosell , Santos-Bezerra Daniele P
Published: August 2021

Background:

Cardiovascular autonomic neuropathy (CAN) is a common complication of type 2 Diabetes mellitus (T2D), and prevalence varies according to the methodology used. CAN should be diagnosed in the subclinical stage when an intensive treatment of T2D could avoid the progression to irreversible phases.

Objective:

Determine the prevalence of early involvement (EI) of CAN in T2D individuals comparing two methodologies.

Methods:

This was a cross-sectional study that included 183 T2D individuals who were monitored in a Tertiary centre. The diagnosis of CAN was based on the results of four cardiovascular autonomic reflex tests (CARTs: expiration-inspiration index, Valsalva maneuver, orthostatic test, and changes in blood pressure after standing) and of seven heart rate variability (7HRV) indices (CARTs plus the spectral analysis). The findings were validated in an independent cohort comprised of 562 T2D individuals followed in a Primary care setting.

Results:

With the use of 7HRV, 30.6% and 77.8% of individuals in the Tertiary and in the Primary centers, respectively, were classified as without CAN; 25.1% and 15.3% as EI and 44.3% and 6.9% as definitive CAN, respectively. The use of CARTs decreased the proportion of individuals without CAN in both centers (7.1% and 47%) and increased the frequency of EI (30.6% and 36.6%) and definitive CAN (62.3% and 16.4%), respectively. The concordance between both evaluated methodologies was weak.

Conclusion:

Higher proportions of T2D individuals were diagnosed with EI and with definitive CAN with the use of CARTs.
The Role of CO-RADS Scoring System in the Diagnosis of COVID-19
Infection and its Correlation with Clinical Signs
Authors: Çomoğlu Şenol , Öztürk Sinan , Topçu Ahmet , Kulalı Fatma , Kant Aydın , Sobay Resul , Arslan Mustafa , Ülgür Hanife Şeyda , Kostakoğlu Uğur , Küçük Eyüp Veli , Karakoç Hanife Nur , Çağlar Merve , Uzuğ Gülsüm , Bağcı Ulaş , Özkan Ömer Faruk , Yılmaz Gürdal
Published: August 2021

Background:

Computed tomography (CT) evaluation systematics has become necessary
to eliminate the difference of opinion among radiologists in evaluating COVID-19 CT findings.

Introduction:

The objectives of this study were to evaluate the efficiency of CO-RADS scoring
system in our patients with COVID-19 as well as to examine its correlation with clinical and laboratory
findings.

Method:

The CO-RADS category of all patients included in the study was determined by a radiologist
who did not know the rtRT-PCR test result of the patients, according to the Covid-19 reporting
and data system of Mathias Prokop et al.

Results:

A total of 1338 patients were included. CT findings were positive in 66.3%, with a mean
CO-RADS score of 3,4 ± 1,7. 444 (33.1%) of the patients were in the CO-RADS 1-2, 894 (66.9%)
were in the CO-RADS 3-5 group. There were positive correlations between CO-RADS score and
age, CMI, hypertension, diabetes mellitus, chronic pulmonary diseases presence of symptoms,
symptom duration, presence of cough, shortness of breath, malaise, CRP, and LDH, while CORADS
score was negatively correlated with lymphocyte count. The results of the ROC analysis
suggested that those with age ≥40 years, symptom duration >2 days, CMI score >1 and/or comorbid
conditions were more likely to have a CO-RADS score of 3-5.

Conclusion:

The CO-RADS classification system is a CT findings assessment system that can be
used to diagnose COVID-19 in patients with symptoms of cough, shortness of breath, myalgia and
fatigue for more than two days.
Facemask Detection Based on Double Convolutional Neural Networks
Authors: Chen Guoqiang , Bai Bingxin , Zhou Hongpeng , Liu Mengchao , Yi Huailong
Published: August 2021

Background:

The study on facemask detection is of great significance because facemask
detection is difficult, and the workload is heavy in places with a large number of people during the
COVID-19 outbreak.

Objective:

The study aims to explore new deep learning networks that can accurately detect facemasks
and improve the network's ability to extract multi-level features and contextual information.
In addition, the proposed network effectively avoids the interference of objects like masks. The new
network could eventually detect masks wearers in the crowd.

Method:

A Multi-stage Feature Fusion Block (MFFB) and a Detector Cascade Block (DCB) are
proposed and connected to the deep learning network for facemask detection. The network's ability
to obtain information improves. The network proposed in the study is Double Convolutional Neural
Networks (CNN) called DCNN, which can fuse mask features and face position information. During
facemask detection, the network extracts the featural information of the object and then inputs it into
the data fusion layer.

Results:

The experiment results show that the proposed network can detect masks and faces in a
complex environment and dense crowd. The detection accuracy of the network improves effectively.
At the same time, the real-time performance of the detection model is excellent.

Conclusion:

The two branch networks of the DCNN can effectively obtain the feature and position
information of facemasks. The network overcomes the disadvantage that a single CNN is susceptible
to the interference of the suspected mask objects. The verification shows that the MFFB and the
DCB can improve the network's ability to obtain object information, and the proposed DCNN can
achieve excellent detection performance.
Bio-guided Studies of Lotus maritimus Aerial Parts and Investigation of
their Antioxidant, Tyrosinase and Elastase Inhibitory Activities
Authors: Schmitt Marie , Magid Abdulmagid Alabdul , Etique Nicolas , Hubert Jane , Duca Laurent , Nuzillard Jean-Marc , Voutquenne-Nazabadioko Laurence
Published: August 2021

Background:

Lotus maritimus L. (Fabaceae) is a perennial herb species with yellow
flowers, growing in Europe, Asia, Middle East and Maghreb. Some flavones and flavonols have
been identified in their leaves and flowers. Their leaf extract was used as a cellulolytic and antiaging
cosmetic ingredient.

Objective:

The aim of this work was to perform antioxidant, anti-tyrosinase and anti-elastase properties
of L. maritimus aerial parts and their chemical profile.

Methods:

A 13C NMR-based dereplication method combined with a bio-guided purification was
used for metabolite identification. Chemical structures were determined by NMR and ESI-MS spectroscopic
methods. The antioxidant properties of the fractions and purified compounds were measured
using CUPRAC, DPPH and hydroxyl radical scavenging assays. Their inhibitory activities
against the fungal tyrosinase and human neutrophil elastase enzymes were also evaluated.

Results:

EtOAc and n-BF fractions were characterized as the most active parts. Twenty-two compounds
were identified from these fractions by using a 13C NMR-based dereplication method. This
process was completed by the purification of minor compounds in the n-BuOH fraction. Eight
known compounds were isolated, including many mono-glycosylated flavonoids with variable substitutions
on the B-ring, allowing structure-activity relationships.

Conclusion:

Twenty-two compounds, including phenolic acids, flavonoids and glycoside derivatives,
were firstly described in L. maritimus. Three quercetin and myricetin-type flavonoids exhibited
good antioxidant activities and all flavonoids tested have moderate effects on elastase inhibition.
A RARE CASE OF RUPTURED ANEURYSM AT THE ORIGIN OF INFERIOR PART OF DUPLICATED MIDDLE CEREBRAL ARTERY
Authors: Firdaus Sani Achmad , Kurniawan Dedy
Published: August 2021

Duplicated middle cerebral artery (DMCA) is an anomalous vessel arises from the internal carotid artery (ICA). This anatomical variation is rare. Aneurysm with this anatomical variation and unusual form was very rare. Even though this kind of aneurysm is rare, it was often ruptured. In this paper, we report a case of 40-years old female with abrupt decreased of consciousness as a chief complaint, along with severe headache one day earlier, no history of head trauma, and there was nuchal rigidity. She didn’t had history of hypertension before. Head computed tomography showed subarachnoid hemmorrhage (SAH) mostly on the left sylvian fissure with Hunt and Hess scale was 3 and Fisher scale was 2, while the cerebral angiography showed duplication of the left middle cerebral artery in which the inferior part of the MCA duplication has ruptured aneurysm at the origin. Treatment option for this aneurysm is endovascular coiling with preserved of the inferior part of duplicated MCA. Result of this treatment shows a good outcome.