bluuebunny/crossref_metadata_2025 huggingface dataset:
Nomogram Based on Clinicopathologic and US Characteristics: Axillary Nodal Evaluation Following Neoadjuvant Chemotherapy in Patients with Biopsy-Proven Node-Positive Breast Cancer
Authors: Huang Jia-Xin , Huang Jia-Hui , Chen Yi-Jie , Wang Xue-Yan , Xu Yan-Fen , Wei Ming-Jie , Tang Li-Na , Pei Xiao-Qing
Published: June 2022

Objective: To avoid surgical over-treatment of the axilla in patients with lymph node (LN) conversion following neoadjuvant chemotherapy (NAC), high-performing axilla staging procedures are needed. This study is designed to develop a convenient modality to predict the axillary response to NAC in breast cancer patients.Methods: In this retrospective study, a total of 1046 patients with breast cancer who received NAC followed by axillary lymph node dissection (ALND) between 2015 and 2021 were identified from a maintained database. The training set included 607 breast cancer patients with biopsy proven positive LNs at initial diagnosis, and receiving NAC followed by ALND. Clinicopathologic and ultrasound (US) characteristics were analyzed, and a nomogram was generated to predict the probability of axillary LNs residual metastasis. The predictive performances of models were assessed using multivariate logistic regression and receiver operator characteristic curve (ROC) analyses. The nomogram integrating clinicopathological and US characteristics was validated with an external cohort of 242 patients.Results: In this study, 49.75% and 32.23% patients achieved axillary pathological complete response (pCR) after NAC in the training and external validation sets, respectively. Multivariate analysis indicated that expression of estrogen receptor (ER), human epidermal growth factor receptor 2 (HER2), Ki-67 score, and clinical nodal stage were independently significant factors for predicting the nodal response to NAC. Location and radiological response of primary tumors, cortical thickness and shape of LNs on US were also significantly associated with nodal pCR. The area under the ROC curve (AUC), estimating the ability of clinicopathologic model to determine axillary status after NAC, was 0.72 and that of US model was 0.81 in the training cohort. AUCs of the nomogram based on clinicopathologic and US characteristics for the training and validation sets were 0.86 and 0.82, respectively.Conclusions: Nomogram incorporating routine clinicopathologic and US characteristics can predict nodal pCR in node-positive breast cancer patients receiving NAC and may be a feasible modality to aid clinicians in treatment decisions.
Metabolomic Profiling of Chronic versus Acute Drug-Induced Liver Injury
Authors: Wang Jiabo , Shi Zhuo , Wei Lu-ge , Huang Ang , Zhai Xing-ran , Niu Ming , Xu Jing , Jing Jing , He Ting-ting , Gao Yuan , Ma Zhi-tao , Zhao Xu , Hou Jun-xing , Guo Yu-ming , Bai Zhao-fang , Gong Man , Yu Yue-cheng , Zou Zheng-sheng , Xiao Xiao-he
Published: June 2022

Background Drug-induced liver injury (DILI) can present as chronic phenotype as well as acute course. However, the underlying mechanisms of chronic DILI, as well as the definition of cut-off point, are largely less researched. We aimed to profile metabolic characteristics of chronic DILI and provide evidence for the cut-off point by serum metabolomics. Methods & ResultsThe sera of DILI patients were divided into Group Ⅰ (0~6 months), Group Ⅱ (6~12 months) and Group Ⅲ (>12 months), based on the duration of liver injury. Totally 2,105 metabolites associated with the DILI duration were screened out as the holistic metabolomic signature (HMS). By unsupervised principal component analysis on HMS dataset, the samples spontaneously represented a two-cluster pattern of the three groups, i.e. Group I as the first cluster and Group II / III as the second cluster, which suggested six months as the potential metabolomic cut-off point of DILI chronicity. Then the differentiation ability of metabolomic signature was validated in an independent cohort. We further screened out 23 most-associated metabolites as the metabolic fingerprint (MFP) for the DILI duration and constructed an eigenmetabolite by dimension reduction. The eigenmetabolite was significantly different in chronic versus acute DILI and was not related to the severity grade of liver injury. Pathway enrichment analysis underlined the enhanced metabolic pathways of lipids in chronic DILI, which are associated with energy metabolism remodeling and immune regulation balance. ConclusionsMFP was different between chronic and acute DILI. Six months might be the potential metabolomic cut-off point in defining chronicity of DILI.
Characterization and Clinical Management of Abnormal Cytology Findings in Pregnant Women - A Retrospective Analysis
Authors: Freudenreich Rosa , Weiss Martin , Engler Tobias , Neis Felix , Henes Melanie
Published: June 2022

Purpose
The diagnosis of cervical intraepithelial neoplasia during pregnancy poses a great challenge to the treating clinician and the patient. According to the current guidelines, watchful waiting during pregnancy can be justified. Only in cases of invasion, immediate treatment may be indicated. However, few data are available on the management of cervical dysplasia during pregnancy. Further research is important for counselling affected women.
Methods
Data of pregnant patients with suspected cervical dysplasia who presented to the University Women’s Hospital Tübingen between 2008 and 2018 were evaluated retrospectively. Colposcopic, cytologic, and histologic assessment was performed for diagnosis. Data on remission, persistence and progression of disease based on histologic and cytologic assessment and the mode of delivery were correlated.
Results
142 patients were enrolled. Cytology at first presentation was PAPIII (-p/-g) in 7.0%, PAPIIID (IIID1/IIID2) in 38.7%, PAPIVa (-p/-g) in 50.0%, PAPIVb (-p) in 2.8%, and PAPV (-p) in 1.4%. All cases with suspected invasion were recorded at initial presentation. Complete histological or cytological remission was observed in 24.4%, partial remission in 10.4%, persistence in 56.3%, and progression in 8.9%. In two cases (1.5%) progression to squamous cell carcinoma occurred.
Conclusions
Watchful waiting of cervical intraepithelial neoplasia during pregnancy seems to be sufficient and oncologically safe. It is important to exclude invasion during pregnancy, to perform frequent colposcopic, cytologic and histologic examinations and to ensure a postpartum follow-up examination to initiate the treatment of high-grade lesions. Spontaneous delivery seems to be safe in patients with cervical dysplasia, Caesarean section is not indicated.
An Efficient Annealing-Assisted Differential Evolution for Multi-parameter Adaptive Latent Factor Analysis
Authors: Li Qing , Pang Guansong , Shang Mingsheng
Published: June 2022

A high-dimensional and incomplete (HDI) matrix is a typical representation of big data. However, advanced HDI data analysis models tend to have many extra parameters. Manual tuning of these parameters, generally adopting the empirical knowledge, unavoidably leads to additional overhead. Although variable adaptive mechanisms have been proposed, they cannot balance the exploration and exploitation with early convergence. Moreover, learning such multi-parameters brings high computational time, thereby suffering gross accuracy especially when solving a bilinear problem like conducting the commonly used latent factor analysis (LFA) on an HDI matrix. Herein, an efficient annealing-assisted differential evolution for multi-parameter adaptive latent factor analysis (ADMA) is proposed to address these problems. First, a periodic equilibrium mechanism is employed using the physical mechanism annealing, which is embedded in the mutation operation of differential evolution (DE). Then, to further improve its efficiency, we adopt a probabilistic evaluation mechanism consistent with the crossover probability of DE. Experimental results of both adaptive and non-adaptive state-of-the-art methods on industrial HDI datasets illustrate that ADMA achieves a desirable global optimum with reasonable overhead and prevails competing methods in terms of predicting the missing data in HDI matrices.
Glucose Tolerance and cardiovascular outcomes after an acute coronary syndrome – Predictive role of the 1-h plus 2-h plasma glucose at the oral glucose tolerance test
Authors: Zywicki Viola , Capozza Paola Francesca , Caravelli Paolo , Prato Stefano Del , De Caterina Raffaele
Published: June 2022

Objective: Impaired glucose tolerance (IGT) has been related to adverse cardiovascular outcomes. We investigated the added value of 1-h plasma glucose (PG) at the oral glucose tolerance test (OGTT) in predicting admission and peak cardiac high-sensitivity troponin T (hs-TnT) and NT-proBNP values in IGT patients admitted for an acute coronary syndrome (ACS).Research Design and Methods: Among 192 consecutive ACS patients, 109 had Hb1Ac and fasting plasma glucose negative for newly diagnosed diabetes. Upon OGTT performed >96 h after admission, 88, conventionally diagnosed as IGT, were divided into: “full glucose tolerance” (1-h PG-OGTT <155 mg/dL and 2-h PG-OGTT <140 mg/dL, N=12); ”early IGT” (1 h-PG-OGTT ≥155 mg/dL and 2-h PG-OGTT <140 mg/dL, N=33); ”late IGT” (1-h PG-OGTT <155 mg/dL and 2-h PG-OGTT ≥140 mg/dL, N=8); and “full IGT” (1-h PG-OGTT ≥155 mg/dL and 2-h PG-OGTT ≥140 mg/dL, N=39). The 4 groups were compared for cardiac markers.Results: The first three groups had similar cardiac marker values, but only full IGT patients had significantly higher admission hs-TnT compared with the 3 other groups [median (interquartile range): 911 (245-2976) vs 292 (46-1131), P<0.001]. Full IGT patients also had higher hs-TnT peak compared with fully glucose tolerant and early IGT patients. Only full IGT patients had longer hospitalization and higher NT-proBNP vs fully glucose tolerant patients (P=0.005). Conclusions: Among non-diabetic ACS patients, only those with both 1-h PG ≥155 mg/dL and 2-h PG ≥140 mg/dL had more severe myocardial injury and longer hospitalization. One-h PG-OGTT importantly contributes to assessing post-ACS cardiac risk.
Feasibility study of low tube voltage CTA for bronchial artery imaging in patients with hemoptysis
Authors: An Jianli , Niu Hongtao , Dong Yanchao
Published: June 2022

To investigate the application of low tube voltage CTA in bronchial artery(BA) imaging in patients with hemoptysis. 119 patients with hemoptysis in our hospital from January 2017 to December 2021 were studied, including 31 patients in the 80kV group (tube voltage: 80kV), 39 patients in 100kV group (tube voltage: 100kV) and 49 patients in the control group (tube voltage: 120kV). The mean CT dose index (CTDIvol, mGy) and effective radiation dose (ED, mSv) of each group were compared and analyzed, and the image quality was evaluated by objective noise measurement: signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) and subjective 5-score method, The differences of CTDIvol, ED, SNR, CNR and image scores between the groups were compared, and the matching rate was analyzed with the blood vessels displayed by DSA. There were significant statistical differences in CTDIvol, ED, SNR, CNR, and image quality scores among the three groups (P<0.05). The comparison results between the groups showed that there was no statistical difference in CTDIvol, ED, and image quality scores between the 80kV and 100kV groups. The matching rates between the images of the three groups and DSA angiography were 96.80%, 97.40%, and 95.90% respectively. It is feasible to use low tube voltage CTA in BA imaging of patients with hemoptysis. The tube voltage of 100kV has the better image quality and lower radiation dose.
Knowledge, Attitude, and Practice of pregnant women toward Intermittent preventive treatment during pregnancy in selected medical centers in banadir region, Mogadishu Somalia.; A Cross-Sectional Study.
Authors: MOHAMUD ABDIRAHMAN KHALIF , ALI IKRAN ABDULKADIR , MOHAMUD BAHJO ISMAIL
Published: June 2022

Background: - To prevent and treat malaria during pregnancy WHO recommended intermittent preventive treatment during pregnancy for every pregnant woman living in an area of malaria-endemic. The objective of this research is to investigate the KAP of pregnant women toward intermittent preventive treatment during pregnancy in selected medical centers in Banadir region, Mogadishu Somalia.Method: - A descriptive cross-sectional study with A sample size of 333 respondents was randomly selected from the pregnant women that visited antenatal care of the three selected hospitals within the data collection period. The data were analyzed using Descriptive statistics & the Chi-square test of the SPSS version 20 to identify general characteristics and associated significant variables.Results: - Study participants who are Married, were illiterate, currently are first pregnant, have a housewife occupation, and have less income were more significant to have poor knowledge, poor attitude, and poor practice.Conclusion: - Pregnant women and their fetal in Banadir Region are at risk, particularly those who were poor education, and income, and have first pregnant were more significantly related to having poor knowledge, poor attitude, and poor practice toward malaria intermittent preventive treatment.
Sex, Racial, Income, and Regional Disparities in PCI Among Cardio-Oncology Patients: Propensity Score and Machine Learning Augmented Nationally Representative Case-Control Study of Over 30 Million Hospitalizations
Authors: Kim Jin wan , Monlezun Dominique , Alsheikh-Kassim Mohammad , Javaid Awad , Honan Kevin , Park Jong kun , Iliescu Gloria , Smith Saleemah , Koutroumpakis Efstratios , Khalaf Shaden , Palaskas Nicolas , Lopez-Mattei Juan , Cilingiroglu Mehmet , Marmagkiolis Konstantinos , Iliescu Cezar
Published: June 2022

Background
Mortality disparities in sex, income, and race are unknown among patients with cancer who undergo percutaneous coronary intervention (PCI).
Methods
Propensity score adjusted multivariable regression for mortality was performed in this case-control study of the 2016 National Inpatient Sample. Regression models by PCI weighted by the complex survey design were adjusted for age, race, income, cancer metastases, NIS-calculated mortality risk by Diagnosis Related Group (DRG), acute coronary syndrome (ACS), and the likelihood of undergoing PCI. Model optimization was conducted with forward and backward stepwise regression, standard regression diagnostics, and performance comparison to backward propagation neural network machine learning (ML) according to root mean squared error (RMSE).
Results
Of 4,659,200 hospitalized adult cancer patients, females were less likely than males to have ACS (41.52% versus 58.48%), and less likely to undergo PCI during ACS (37.86% versus 62.14%). Multivariable regression in the subgroup of cancer patients who underwent PCI found significant disparities in mortality reduction according to sex, males (OR 0.56; 95%CI 0.50–0.62; p < 0.001) versus females (OR 0.61; 95%CI 0.53–0.69; p < 0.001), and race, whites (OR 0.50, 95%CI 0.46–0.55, p < 0.001) versus non-whites (OR 0.58, 95%CI 0.49–0.68, p < 0.001). However, there was no significant mortality disparity according to region, the interaction of income and region, nor the interaction of non-white race and region. There were significant regional disparities in PCI frequency among patients with cancer. RMSE confirmed comparable model performance to ML analysis.
Conclusion
Our nationally representative study suggests that females are less likely than males to undergo PCI and survive, among patients with cancer. Mortality disparities were observed according to race, but not income and region in PCI among patients with cancer.
Characteristics of ocular surface in neurotrophic keratitis induced by trigeminal nerve injury following neurosurgery
Authors: Xie Caiyuan , Liu Bo , Zhao Xiaoyu , He Qing , Liu Lin , Wei Ruihua
Published: June 2022

Purpose: To analyse and quantify ocular surface parameters in patients with unilateral neurotrophic keratitis (NK) induced by trigeminal nerve injury post-neurosurgery.Methods: The study included 26 unilateral NK patients who had undergone neurosurgery, and 20 matched normal controls. Demographic and clinical characteristics of all participants were collected and analysed. Slit lamp examination, Cochet–Bonnet aesthesiometry, Keratograph 5M, and LipView interferometer were performed on both eyes of 17 mild NK patients. For nine moderate/severe NK patients, sub-basal nerve density was measured by in vivo confocal microscopy.Results: Of the 26 patients, nine had acoustic neuroma, nine had trigeminal neuralgia, and eight had neoplasms. Facial nerve paralysis was observed in one of the 17 mild NK eyes (5.9%) and seven of the nine moderate/severe NK eyes (77.8%). Comparison of contralateral and normal control eyes, 26 NK eyes showed significantly reduced sensitivity in five corneal regions (P<0.05). Corneal sensitivity in moderate/severe NK eyes was significantly lower than in mild NK eyes (P<0.05). Moderate/severe NK eyes had poor visual acuity, and their sub-basal nerve density was lower than that of the controls. The onset of the moderate/severe NK was between 2 months and 72 months after neurosurgery. The number of total blinks significantly decreased (P<0.05), and the number of partial blinks and partial blinking rate significantly increased in mild NK eyes (P<0.05). For mild NK patients, the first non-invasive tear breakup time (NITBUT) and average non-invasive tear breakup time showed a significant decrease (P<0.05). Conclusions: Patients with NK induced by trigeminal nerve injury following neurosurgery had decreased corneal sensitivity to various degrees accompanied by increased partial blinks and shortened NITBUT. The severity of NK is related to the severity of the corneal sensory impairment. Facial nerve paralysis can worsen the clinical progression of NK.Trial registration Chinese Clinical Trial Registry (ChiCTR2100044068, Date of Registration: March 9, 2021).
The RNA methylase FTO mediates circRNF220 demethylation, and circRNF220 binds to serine/arginine-rich splicing factor 1 to promote the progression of acute myeloid leukemia
Authors: He JinHua , Han ZePing , Luo WenFeng , Sen Jian , Xie FangMei , Pan Ting , Hong Qu , Guo ZhongHui , Li JianHao , Li YuGuang , Cheng HanWei
Published: June 2022

Background: The key circular RNAs (circRNAs) and the molecular mechanisms by which they regulate the progression of acute myeloid leukemia (AML) in adults are unclear.Methods: We used a circRNA microarray to analyze the differentially expressed circRNAs in peripheral blood mononuclear cells of newly diagnosed adult AML patients. Reverse transcription-PCR, fluorescence in situ hybridization, Sanger sequencing, and ribonuclease R tests were used to examine circRNF220 loop formation and stability and its potential value in AML diagnosis. Cell Counting Kit-8, flow cytometry, and subcutaneous tumor assays were used to detect the effects of circRNF220 on the proliferation and apoptosis of the HL-60 and THP-1 cell lines. RNA antisense purification, methylated RNA immunoprecipitation, and RNA pull-down assays were used to identify circRNF220-binding proteins and microRNAs.Results: CircRNF220 was located in the cytoplasm and was more stable than linear RNF220. The area under the curve value of circRNF220 for the diagnosis of AML was 0.8314. Silencing circRNF220 expression inhibited the growth and promoted the early apoptosis of HL-60 and THP-1 cells. CircRNF220 had no competitive endogenous relationship with microRNAs. The RNA methylase FTO regulated the demethylation and expression of circRNF220. The RNA-binding protein serine/arginine-rich splicing factor 1 (SRSF1) and circRNF220 co-localized in the cytoplasm, and circRNF220 promoted SRSF1 expression. Furthermore, silencing circRNA220 reduced the tumorigenicity of AML cells in vivo.Conclusions: CircRNF220 is a potential biomarker for the diagnosis of adult AML. FTO mediates circRNF220 demethylation. and circRNF220 binds to SRSF1 to promote the progression of AML.
Regional groundwater sustainability assessment through enhancing conveyance and application efficiencies of irrigation water
Authors: Kumar Manoj , Singh D. K. , Sarangi A. , Mani Indra , Khanna Manoj
Published: June 2022

Groundwater depletion is a big sustainability challenge of 21st century all around the world. Local water authorities are in urgent need of concrete and focused steps to ensure sustainable groundwater management policies as quickly and as effectively as possible to achieve the sustainable development goals. For sustainable and efficient utilization of groundwater resources a study was conducted in farmer’s field of Rasoolpur jatan village in Western U.P, India. This study presents a new approach to explore and evaluate the impact of various water management technologies on water table fluctuations in order to build up a sustainable groundwater use strategy. In this paper modeling was done to simulate the future groundwater table behaviour and give the alternate course of management options. Sugarcane crop covered the maximum part of study area and irrigation is being done through earthen open channel. When water is applied through earthen channel with 60% application efficiency (Ea), the water table would decline at 0.57 m/yr. The water table would decline at 0.39 m/yr, when application efficiency of unlined earthen channel increased to 65%. To avoid conveyance losses water is applied through pipe distribution network with 79% application efficiency, in this case water table would rise by 0.05 m/yr and when irrigation is done with drip system with Ea = 90%, water table would rise by 0.27 m/yr. The groundwater level for the year 2030 under four scenarios projected as 213.84, 217.20, 225.39 and 229.37 m respectively. Simulated results suggest that the sustainability of groundwater could be ensured in the study area by enhancing efficiency of irrigation water or shift from traditional irrigation methods to modern irrigation i.e. drip and sprinkler irrigation system or timely transformation like change the cropping pattern.
Blockchain-based Secure Data Transmission for Internet of Underwater Things
Authors: Razzaq Abdul
Published: June 2022

Internet of Things (IoTs) is an integrated network collection of heterogeneous objects which enable seamless integration between systems, humans, devices, and various other things, to support pervasive computing for smart systems. IoT-driven systems and sensors continuously ingest data resulting in an increased volume and velocity of information which can lead to critical concerns such as security of the data and scalability of the system. The Internet of Underwater Things (IoUTs) is a specific genre of IoTs in which data related to oceanic ecosystems is continuously sensed through underwater sensors. IoUT has emerged as an innovative paradigm to support smart oceans. However, there are several critical challenges which IoUT system designers must consider such as (i) scalability of the system to handle large volumes of oceanic data and (ii) security of data that is transmitted from IoT sensors deployed underwater. Blockchain as a newly emerged technology and an enabling platform allows decentralized and secure transmission of data among a wide group of untrustworthy parties. This research aims to exploit blockchain technology to secure IoUT data transmission by exploiting Interplanetary File System (IPFS) method. Additionally, this study also addresses the system's scalability in two aspects, (i) scalability, and (ii) security. We used a case study-based approach and performed experiments to evaluate the proposed solution's usability and efficiency in terms of query response (i.e., performance), and algorithmic execution (i.e., efficiency). The proposed solution unifies blockchain technologies to secure IoT-driven systems and provides guidelines to engineer and develop next-generation of robust and secure blockchain-aided distributed IoT systems.
Genomic analyses identify significant molecules and signaling pathways in ameloblastoma
Authors: Wang Mengshan , Wang Xueying , Chung Andrew
Published: June 2022

Ameloblastoma is a locally aggressive odontogenic neoplasm that occurs in the vicinity of the mandibular molars or ramus. However, the mechanisms of ameloblastoma are still unclear. Here, our objective is to identify the key genes and signaling pathways by analyzing the RNA-seq data. The GSE186489 was created by the Illumina HiSeq 2500 (Homo sapiens). The gene enrichments indicated that the Chemical carcinogenesis − reactive oxygen species and prion disease are the key related signaling pathways in the development of ameloblastoma. Moreover, we determined several interactive genes including KIF11, BUB1, CDCA8, CDC20, ASPM, TOP2A, CCNB1, AURKA, TTK, and NCAPG. Our study may shed insights on the mechanism of ameloblastoma.
WITHDRAWN: Autothermal process intensification of continuous flow reactors for fuel cell applications
Authors: Chen Junjie
Published: June 2022

Process Intensification has attracted considerable interest as a potential means of process improvement and to meet the increasing demand for sustainable production. Process Intensification aims to improve yields and selectivity by using novel reactions or running reactions at more extreme parameters. This study relates to autothermal process intensification of continuous flow reactors for fuel cell applications. Computational fluid dynamics simulations are conducted to better understand the autothermal process within the continuous flow reactor. The effects of wall heat conduction properties and channel dimensions on autothermal process intensification are investigated. The results indicate that autothermal process intensification can be achieved for the continuous flow reactor. Reaction heat flux profiles are greatly affected by the dimensions of the continuous flow reactor. The peak reaction heat flux increases with the channel dimensions while maintaining the flow rates. The thermal conductivity of the channel walls is fundamentally important. Thermally conductive ceramics and metals are well-suited. Wall materials with poor heat conduction properties degrade the reactor performance. Materials with high thermal conductivity are preferred for the channel walls. Design recommendations are made for autothermal process intensification of continuous flow reactors.
WITHDRAWN: Physical insights in experimental studies of transport phenomena in low-dimensional nanomaterials from the perspective of thermal conductivity
Authors: Chen Junjie
Published: June 2022

In physics, the study of transport phenomena concerns the exchange of mass, energy, charge, momentum and angular momentum between observed and studied systems. Mass, momentum, and heat transport all share a very similar mathematical framework, and the parallels between them are exploited in the study of transport phenomena to draw deep mathematical connections that often provide very useful tools in the analysis of one field that are directly derived from the others. The heat transport phenomena in low-dimensional nanomaterials were studied to understand the characteristics of nanoscale thermal conduction. The parallel thermal conductance technique was employed to determine the thermal conductivity. The importance of cross-sectional and area bulk density was determined experimentally. The results indicated that the low-dimensional nanomaterials are very efficient at conducting heat. The structure, purity, and alignment of the low-dimensional nanomaterials play a fundamentally important role in determining the characteristics of nanoscale thermal conduction. The low-dimensional nanomaterials generally have high thermal conductivity. The presence of non-carbonaceous impurities degrades the thermal performance due to the low degree of bundle contact. The thermal conductivity may present power law dependence with temperature. The specific thermal conductivity decreases with increasing bulk density. At room temperature, a maximum specific thermal conductivity is obtained but Umklapp scattering occurs. The specific thermal conductivity of the low-dimensional fiber nanomaterials is significantly higher than that of the low-dimensional film nanomaterials due to the increased degree of bundle alignment.
Teacher Perceptions of Culturally and Linguistically Diverse Newcomer Parents: Shifting the Paradigm from Deficit Perspectives to Asset-Based Approaches
Authors: Nikolovski Johnny
Published: June 2022

This study explores teacher perceptions of newcomer parents and investigates how a small sample of teachers are making the shift from deficit to asset-based approaches to working with newcomer parents. This research uses one-on-one semi-structured interviews with three Toronto District School Board high school teachers to examine their perceptions of newcomer families living in Toronto, Ontario. Critical race theory is used as the theoretical framework for this study to critically analyse teachers’ conceptualization of asset-based approaches. Research findings reveal specific strategies used by the participants in incorporating asset-based approaches to working with newcomer parents and their children. This study also provides critical reflection opportunities for teachers who wish to engage in asset-based work in and beyond their multicultural classroom.
MiR-455-3p inhibits hepatocellular carcinoma tumorigenesis, lymphangiogenesis and angiogenesis via regulating vascular endothelial growth factor C and vascular endothelial growth factor receptor-2
Authors: Bin Xiaoyun , Zhou Sufang
Published: June 2022

Background: MicroRNAs (miRNAs), which may function as either tumor suppressor genes or oncogenes, exert considerable regulatory influence on biological processes. Previous studies have shown that miR-455-3p is significantly downregulated in hepatocellular carcinoma (HCC); however, the specific role of miR-455-3p in HCC is unclear. Methods: We used qRT-PCR to detect the levels of miR-455-3p in HCC cells. We used colony formation assay, EdU assay, and CCK-8 assay to check the effect of miR-455-3p on the proliferation of HCC and HuH-7 cells. Further, transwell and scratch assays were employed to identify the role of miR-455-3p in invasion and migration in these cells. Western blot analysis, angiogenesis assay, dual-luciferase reporter gene assay, and bioinformatic analysis were also performed to investigate the underlying molecular mechanisms. Results: MiR-455-3p was down-regulated in the HCC cells. In vitro experiments showed that miR-455-3p overexpression inhibits HCC cell proliferation, migration, and invasion. Interestingly, vascular endothelial growth factor C (VEGFC) was identified as a downstream target of miR-455-3p. Additionally, overexpression of miR-455-3p in HCC cells and human umbilical vein endothelial cells (HUVECs) led to a decreased expression of VEGFC and the vascular endothelial growth factor receptor (VEGFR)-2. This subsequently led to a downregulation of the phosphatidylinositol 3-kinase (PI3K)-AKT signaling pathway. Furthermore, in vivo overexpression of miR-455-3p significantly suppressed the tumorigenicity of HuH-7 cells in nude mice and inhibited both angiogenesis and lymphangiogenesis in tumor xenografts. Conclusions: Our findings suggest that miR-455-3p plays a role in HCC tumorigenesis, at least in part by modulating angiogenesis and lymphangiogenesis by targeting VEGFC and simultaneously blocking the AKT signaling pathway.
REA: resource exergy analysis - Guidelines for evaluating and comparing energy systems
Authors: Jentsch Andrej
Published: June 2022

Evaluating energy systems using resource exergy analysis (REA) is key to ensure that climate targets are reached in time.The reason for this effect is wastefulness. Wastefulness, even in otherwise GHG-free energy systems, increases the amount of energy required to cover the total energy demand. If using GHG-free energy systems wastefulness leads to reduced availability of GHG-free energy for the rest of the energy system. Since the energy demand is largely independent of energy production, wastefulness increases overall fossil fuel use.REA allows to assess wastefulness comprehensively and thus obtain a key indicator in addition to GHG emissions, that is grounded in science, namely resource exergy consumption.This publication provides guidelines to the application of resource exergy analysis (REA) with a focus on energy systems evaluation.REA is a well-tested application of exergy analysis to the field of technology comparison that can replace the less comprehensive primary energy analysis and reduce the risk of suboptimal decisions.
Curricularização da extensão: reflexões sobre a conservação dazona de amortecimento da Reserva Biológica (REBIO) do Jaru
Authors: SILVA Mônica Veloso , SILVA Edegmaria da Costa , JESUS Denilda Ribeiro Araujo de , BARROS Luan Garcia Pereira , MENDONÇA Andreza Pereira , FELZKE Lediane Fani
Published: June 2022

Este relato de experiência descreve as ações realizadas de forma interdisciplinar de Manejo de Unidades de Conservação e Ética Profissional, Direitos Humanos e Relações Étnico-Raciais do projeto de curricularização da extensão: “Áreas protegidas de Rondônia: aspectos florestais e humanos”. O objetivo do projeto foi relatar a prática extensionista que teve como assunto a zona de amortecimento da Reserva Biológica (REBIO) do Jaru, através de um vídeo dinâmico apresentado para as turmas de alunos do ensino médio das escolas públicas do perímetro urbano e rural. No contexto da pandemia por COVID-19, o vídeo mostrou-se um meio acessível para divulgar a REBIO do Jaru, bem como as ameaças que a circundam, junto à comunidade local. Portanto, as práticas relatadas demonstraram a importância da conservação da biodiversidade do bioma amazônico e a evolução dos acadêmicos enquanto protagonistas dessa atividade de extensão.
Massive holographic QFTs in de Sitter
Authors: Penín José Manuel , Skenderis Kostas , Withers Benjamin
Published: June 2022

We study strongly coupled mass-deformed-CFT on a fixed de Sitter spacetime in three dimensions via holography.
We elucidate the global causal structure of the four-dimensional spacetime dual to the de Sitter invariant vacuum state.
The conformal boundaries of de Sitter appear as spacelike defects sourced by the mass deformation, which extend into the bulk as curvature singularities in AdS.
We compute all one- and two-point functions of the deformed-CFT stress tensor and a scalar operator order-by-order in the mass deformation for a simple holographic model. These correlation functions admit a spectral representation as a sum of simple poles corresponding to normalisable modes in the bulk.
HEPATIC GLYCOGENOSIS: AN UNDER-RECOGNIZED COMPLICATION OF POORLY CONTROLLED DIABETES MELLITUS TYPE 1(THREE CLINICAL CASES)
Authors:   Endocrinology, Diabetology and MetabolicDiseasesDepartment AvicennaMilitary Hospital, Marrakech., Idrissi Ayoub , Meftah Azzelarab ,   Endocrinology, Diabetology and MetabolicDiseasesDepartment AvicennaMilitary Hospital, Marrakech., El Jadi Hamza ,   Endocrinology, Diabetology and MetabolicDiseasesDepartment AvicennaMilitary Hospital, Marrakech., Abainou Lahoussaine ,   Endocrinology, Diabetology and MetabolicDiseasesDepartment AvicennaMilitary Hospital, Marrakech., Elhadri Sanae ,   Endocrinology, Diabetology and MetabolicDiseasesDepartment AvicennaMilitary Hospital, Marrakech., Amine Azami Mohamed ,   AnatomicPathology Service Avicenne Military Hospital, Marrakech., Baizri Hicham ,   Endocrinology, Diabetology and MetabolicDiseasesDepartment AvicennaMilitary Hospital, Marrakech.
Published: June 2022

Hepaticglycogenosis is an inherited abnormality characterized by excessive glycogen accumulation in hepatocytes. It is a hepatic complication of poorly controlled type 1 diabetes mellitus. It combines hepatomegaly, growth failure, and hepatic cytolysis as well ascushing-like feature. Hepatic glycogenosis is only diagnosed by liver biopsy. We report the observation of three clinical cases: NÂ°1: A 16-year-old male, with type 1 diabetes mellitus since a year. Admitted for keto-acidosic decompensation, he presented dyspnea, a distended abdomen with painless hepatomegaly. Abdominal ultrasound showed 21 cm homogeneous hepatomegaly. The anatomo-pathological study of the liver biopsy confirmed the diagnosis of hepatic glycogenosis.NÂ°2:An 18-year-old female, with type 1 diabetes mellitusfor 14 years with a severe growth failure, she presented a major cytolysis with hepatic cholestasis for 5 years. Abdominal ultrasound showed homogeneous hepatomegaly.Theanatomo-pathological study of the liver biopsy confirmed the diagnosis of hepatic glycogenosis.NÂ°3:A 19-year-old female, with type 1 diabetes mellitusfor 8 years, epilepsy and delayed puberty. The biological check-up had objectified a very significant cytolysis and major dyslipidemia. Abdominal ultrasound shows hepatomegaly associated with hepatic steatosis. A liver biopsy was indicated, but not performed as the patient was lost to follow-up.The discovery of hepatomegaly in a patient with poorly controlled type 1 diabetes mellitus must evoke a variety of diagnoses. Although hepatic glycogenosis is a rare diagnosis, it should not be ignored by the clinician.Through these clinical cases, the pathophysiology of hepatic glycogenosis, complications as well as therapeutic management has been discussed.
IMAGING ASPECT OF TYMPANOSCLEROSIS : A CASE REPORT
Authors: Nashi L. , Belgadir H. , Ghanbouri I. , Merzem A. , Amriss O. , Moussali N. , Elbenna N.
Published: June 2022

We report a 50-year-old female case with tympanosclerosis, revealed by a hearing loss on the left side. A CT scan of the petrous bonerevealedlesions of middle ear. This case shows the interest of imaging in the ckaracterization of tympanosclerosis lesions.
INVESTIGATION OF THE EFFECT OF ETCHING CURRENT ON TEXTURED SILICON SURFACE FOR FORMING POROUS SILICON LAYERS ACTING AS AN ANTI-REFLECTION COATING.
Authors:   Department of Physics, Faculty of Girls for Arts, Science and Education, Ain Shams University., Abd-Elrasol H.M. , Farag M.A. ,   Department of Physics, Faculty of Science, Ain Shams University., Youssef G.M. ,   Department of Physics, Faculty of Science, Ain Shams University., Elzahed H.A. ,   Department of Physics, Faculty of Girls for Arts, Science and Education, Ain Shams University.
Published: June 2022

The porous silicon layers (PSLs) acting as an anti-reflection coating (ARC) formed with different surface porosities are prepared on n+ p textured crystalline CZ- silicon by electrochemical etching (ECE) in HF-basedelectrolyte using different current densities.The morphological properties of the PSLs are investigated by scanning electron microscopy (SEM). The results show that the porous silicon structure had a smaller pore size range, and the optical properties of the textured surfaces are studied using photoluminescence â€œPLâ€ and reflectivity measurements. The band gap energy of the prepared PSLs increases to 1.904 eV. The reflectivity of the PSLs decreases to 0.75% in a wavelength range (350â€“750) nm. The current-voltage (I-V) characteristics of Al/ PS/n+ p/Al junction are investigated which reveal an increment in the resulting short-circuit current density and the open-circuit voltage up to 2.96 mA/cm2 and 0.385 V, respectively. These results show an improvement in the fill factor by 48.5%. The photosensitivity of PSLs solar cells showed a noticeable enhancement in quantum efficiency of the PS cells by increasing the porosity.
MIXED MALARIA INFECTION: ABOUT AN IMPORTED CASE AND REVIEW OF THE LITERATURE
Authors:   Laboratory of Parasitology-Mycology, Ar-Razi Hospital, CHU Mohammed VI, Marrakech., Babokh Fatima ,   Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech, Morocco., Nachat Soumia ,   Laboratory of Parasitology-Mycology, Ar-Razi Hospital, CHU Mohammed VI, Marrakech.,   Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech, Morocco., Ait Boucetta Ibtissam ,   Laboratory of Parasitology-Mycology, Ar-Razi Hospital, CHU Mohammed VI, Marrakech.,   Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech, Morocco., El Amrani Youssra ,   Laboratory of Parasitology-Mycology, Ar-Razi Hospital, CHU Mohammed VI, Marrakech.,   Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech, Morocco., Rahali Fatimzahra ,   Laboratory of Parasitology-Mycology, Ar-Razi Hospital, CHU Mohammed VI, Marrakech.,   Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech, Morocco., El Hakkouni Awatif ,   Laboratory of Parasitology-Mycology, Ar-Razi Hospital, CHU Mohammed VI, Marrakech.,   Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech, Morocco.
Published: June 2022

Mixed malaria infections with Plasmodium are rare and can lead to more serious complications than a single infection. They are particularly common in travelers to malaria-endemic areas. Proper diagnosis and treatment of cases help to control this infection.We report the case of a rare and severe malaria infection, associating two plasmodial species: Plasmodium falciparum and P.vivax, with high parasitemia and fatal complication.
MANAGEMENT OF FETAL ANEMIA AND THROMBOCYTOPENIA WITH INTRAUTERINE BLOOD TRANSFUSION
Authors:   Assistant Professor, Department of Pharmacology, Global College of Pharmaceutical Technology, Krishnanagar, West Bengal., Pal Rohan , Shree Nidhi ,   Under Graduate Student, Global College of Pharmaceutical Technology, Krishnanagar, West Bengal., Jana Snehasis ,   Under Graduate Student, Global College of Pharmaceutical Technology, Krishnanagar, West Bengal., Mishra Arunava ,   Under Graduate Student, Global College of Pharmaceutical Technology, Krishnanagar, West Bengal., Kumari Alka ,   Under Graduate Student, Global College of Pharmaceutical Technology, Krishnanagar, West Bengal., Bhattacharjee Arin ,   Principal, Global College of Pharmaceutical Technology, Krishnanagar, West Bengal.
Published: June 2022

Fetal anemia and fetal thrombocytopenia are two of the most unsmiling complications in pregnant women, and they can lead to perinatal mortality and morbidity. After long years of study with intravascular intrauterine blood transfusion, a number of varieties of implications have been described. Intrauterine Blood Transfusion (IUBT) is considered the best method in the case of fetal anemia because it is caused by red cell alloimmunization. Not only for red blood cell transfusion, this method can also be used for the transfusion of platelets to thrombocytopenic fetuses in pregnant women. It is generally detected after a child is born who is symptomatic and shows signs of bleeding in the brain and skin. The biggest milestone for the clinician is to give preventive treatment in next pregnancy. Pregnancies at risk require serial monitoring, and Fetal Middle Cerebral arterial (MCA) Doppler is the non-invasive test that is now proving to be the choice for monitoring. IVIG (Intravenous immunoglobulin) is used to manage severe Rh-immunization and is now showing promising effects. Indications like Parvovirus B19, Fetomaternal hemorrhage (FMH), Fetal SacrococcygealTeratoma (SCT), Twin-twin transfusion syndrome, placental chorioangioma diseases, or other infections can be treated with this method. This review covers fetal transfusion techniques and explores current management of fetal anemia and thrombocytopenia.
SERUM MAGNESIUM LEVEL IN TYPE2 DIABETES MELLITUS WITH SPECIAL REFERENCE TO DIABETIC RETINOPATHY
Authors:   Post Graduate Trainee, Department Of Medicine, Jorhat Medical College And Hospital, Jorhat, Assam., R.H Ahmed , U.R Pegu ,   Associate Profeesor, Department Of Medicine,Jorhat Medical College And Hospital, Jorhat, Assam., T. Gogoi ,   Professor and Hod, Department Of Ophthalmology, Jorhat Medical College And Hospital, Jorhat, Assam., B. Devi ,   Associate Profeesor, Department Of Biochemistry, Jorhat Medical College And Hospital, Jorhat, Assam.
Published: June 2022

Background: Diabetes mellitus (DM) is a worldwide, growing epidemic, with an estimated 415 million adults globally. Patients with diabetes are at increased risk of death and a triad of serious diabetes-specific complications (neuropathy, nephropathy, and retinopathy) and other associated complications. Magnesium is an intracellular cation and co-enzyme for various reactions of glycolytic pathway. Hence, we evaluated serum magnesium level in type 2 DM with and without diabetic retinopathy. Materials and methods: The study is carried out on 40 patients of type 2 DM with retinopathy and 40 patients of type 2 DM without retinopathy. All patients are subjected to the detailed history taking, ocular examination, and investigations like serum magnesium, FBS, PPBS, glycated hemoglobin. Results: The study revealed that there is a significant decrease in serum magnesium level in diabetic patients with retinopathy than without retinopathy (t= -6.297, df= 58 p= <0.001).Similarly Fasting Blood sugar, post prandial blood sugar and duration of diabetes also show significant difference. Conclusion: As magnesium level decreases in patients with type 2 DM, the prevalence of retinopathy increases. Timely monitoring of serum magnesium levels and glycated hemoglobin as well as appropriate interventions would be beneficial in early detection and treatment of diabetic retinopathy.
Discrimination and sexual violence against women and girls in conflict-related settings. An approach to the colombian case from the concluding observations of the CEDAW Committee
Authors: Chaparro Piedrahita Laura
Published: June 2022

The concluding observations issuance by the Committee on the Elimination of All Forms of Discrimination against Women is arguably the single most important activity of this human rights treaty body. It provides an opportunity to deliver a comprehensive overview of the status of human rights protection for women in a state party and the submission of forms of guidance that can stimulate systemic advancement.
Although the Committee recognizes and welcomes the efforts of Colombia in undertaking legislative reforms in the health, education, and service sectors to eradicate discriminatory gender stereotypes, access for women to justice, especially in cases of sexual and domestic violence, guarantees for participation in political and public life, and other actions for the fulfillment of their rights, there are still serious concerns about gross human rights violations taking place in the country; one the most complex issue is sexual violence in the context of the armed conflict as many non-state actors are still using these brutal practices to achieve military purposes and as spoils of war. 
This paper aims to analyze the causes of conflict-related sexual violence, how they constitute a form of prejudice and the intersectionality of this phenomenon with other forms of discrimination against women. Finally, it introduces some recommendations on additional related issues that seem to have been omitted by the Committee, even though they constitute severe breaches of the obligations and duties of the government under international law.