bluuebunny/crossref_metadata_2025 huggingface dataset:
Drivers of Wettability Alteration for Oil/Brine/Kaolinite System: Implications for Hydraulic Fracturing Fluids Uptake in Shale Rocks
Authors: Xie Quan , Chen Yongqiang , You Lijun , Hossain Md Mofazzal , Saeedi Ali
Published: June 2018

Hydraulic fracturing technique is of vital importance to effectively develop unconventional shale resources. However, the low recovery of hydraulic fracturing fluids appears to be the main challenge from both technical and environmental perspectives in the last decade. While capillary forces account for the low recovery of hydraulic fracturing fluids, the controlling factor(s) of contact angle, thus wettability, has yet to be clearly defined. We hypothesized that the interaction of oil/brine and brine/rock interfaces governs the wettability of system, which can be interpreted using Derjaguin–Landau–Verwey–Overbeek (DLVO) and surface complexation modelling. To test our hypothesis, we measured a suit of zeta potential of oil/brines and brine/minerals, and tested the effect of ion type (NaCl, MgCl2 and CaCl2) and concentrations (0.1, 1, and 5 wt %). Moreover, we calculated the disjoining pressure of the oil/brine/mineral systems and compared with geochemical modelling predictions. Our results show that cation type and salinity governed oil/brine/minerals wettability. Divalent cations (Ca2+ and Mg2+) compressed the electrical double layer, and electrostatically linked oil and clays, thus increasing the adhesion between oil and minerals, triggering an oil-wet system. Increasing salinity also compressed the double layer, and increased the site density of oppositely charged surface species which made oil and clay link more strongly. Our results suggest that increasing salinity and divalent cations concentration likely decrease water uptake in shale oil reservoirs, thus de-risking the hydraulic fracturing induced formation damage. Combining DLVO and surface complexation modelling can delineate the interaction of oil/brine/minerals, thus wettability. Therefore, the relative contribution of capillary forces with respect to water uptake into shale reservoirs, and the possible impairment of hydrocarbon production from conventional reservoirs can be quantified.
Changes in Fish Consumption Desire and Its Factors: A Comparison between the United Kingdom and Singapore
Authors: Supartini Atin , Oishi Taro , Yagi Nobuyuki
Published: June 2018

It is widely known that rapid population growth and income improvement in some developing countries, and growing health consciousness in some developed countries, are the main factors that have contributed to the global increase in the consumption of fishery products in the past few decades. While a detailed analysis of fish consumption behavior is being conducted in several countries, there are other countries where changes in fish consumption desire and their social and psychological factors are not fully clarified. This study investigates the changes in fish consumption desire and its associated factors in the United Kingdom (UK) and Singapore. Primary data were gathered from 1200 participants through a web questionnaire survey in the UK and Singapore. The results show that approximately five times as many respondents stated that the desire to purchase fish had increased in both the UK and Singapore compared to those that believed it had not 10 years ago. Second, the increase in fish consumption in the UK is positively associated with younger age, cheaper price, the health benefits of fish, concern over the health of meat, and religion. Third, the increase in fish consumption in Singapore is positively associated with cheaper prices and is negatively associated with concerns over sustainability.
On the Origin of Morphological Structures of Planetary Nebulae
Authors: Kwok Sun
Published: June 2018

We suggest that most of the mass in planetary nebulae (PNe) resides in the equatorial region and the spherical envelope and the optically bright lobes of PNe are in fact low-density cavities cleared out by fast outflows and photoionized by UV photons leaked from the torus. The nature of multi-polar PNe is discussed under this framework.
Effect of Skeletal Muscle and Fat Mass on Muscle Strength in the Elderly
Authors: Nonaka Koji , Murata Shin , Shiraiwa Kayoko , Abiko Teppei , Nakano Hideki , Iwase Hiroaki , Naito Koichi , Horie Jun
Published: June 2018

It is important for elderly people to maintain or improve muscle strength and for clinicians to know the factors that affect muscle strength. Therefore, the purpose of this study was to compare the effects of fat mass (FM) and skeletal muscle mass (SMM) on muscle strength. The participants included 192 community-dwelling elderly women. The SMM and FM, grip strength, and knee extension strength were measured. Data were evaluated using stepwise multiple linear regression analysis, which was performed with grip or knee extension strength as a dependent variable and the SMM and FM of the upper and lower limbs as the independent variables. The SMM and FM of the upper limbs were associated with grip strength, whereas the SMM but not the FM of the lower limbs was associated with knee extension strength. These findings suggest that there may be thresholds for the SMM/FM ratio to affect muscle strength.
Temporal Trends in Sports Participation among Adolescents between 2001 and 2015: A French School- and Territory-Based Study
Authors: Luiggi Maxime , Travert Maxime , Griffet Jean
Published: June 2018

Improving adolescents’ levels of sport and physical activity (PA) is an official public health issue. French national government plans were launched in 2001, 2006, and 2011 to improve the participation levels of citizens. These plans should be monitored. To date, information on temporal trends in sports has come from the national population. However, no data are available to measure temporal trends in different territories across the country. Our study aimed to measure these trends among a representative sample of adolescent students of the third biggest French region (Bouches-du-Rhône), but also one of the poorest, between 2001 and 2015. Three surveys were conducted in 2001, 2008, and 2015 in high schools (n = 3218). Logistic regressions adjusted for age were used to determine the impact of socioeconomic status (SES) on sports participation and to measure the changes in sport participation rates. Participation declined among all subgroups of adolescents: from 79.0% to 65.8%. The greatest decrease was observed for boys with a high SES, whilst the lowest was for the high-SES girls. We observed that SES inequalities in access to sport increased among the girls, whilst they reduced among the boys. National government plans seem to have had limited success in this territory. Next to national studies, there is a need to develop territory specific studies which could show important disparities across the national territory.
Development of a Cumulative Exposure Index (CEI) for Manganese and Comparison with Bone Manganese and Other Biomarkers of Manganese Exposure
Authors: Rolle-McFarland Danelle , Liu Yingzi , Zhou Jieqiong , Mostafaei Farshad , Zhou Yuanzhong , Li Yan , Fan Quiyan , Zheng Wei , Nie Linda H. , Wells Ellen M.
Published: June 2018

Manganese (Mn) exposure can result in parkinsonism. However, understanding of manganese neurotoxicity has been limited by the lack of a cumulative Mn biomarker. Therefore, the current goal was to develop Mn cumulative exposure indices (MnCEI), an established method to estimate cumulative exposure, and determine associations of MnCEI with blood Mn (BMn), fingernail Mn (FMn), and bone Mn (BnMn). We completed a cross-sectional study of 60 male Chinese workers. Self-reported occupational history was used to create two MnCEIs reflecting the previous 16 years (MnCEI16) and total work history (MnCEITOT). An in vivo neutron activation analysis system was used to quantify BnMn. BMn and FMn were measured using ICP-MS. Mean (standard deviation) MnCEITOT and MnCEI16 were 37.5 (22.0) and 25.0 (11.3), respectively. Median (interquartile range) BMn, FMn, and BnMn were 14.1 (4.0) μg/L, 13.5 (58.5) μg/g, and 2.6 (7.2) μg/g dry bone, respectively. MnCEI16 was significantly correlated with FMn (Spearman’s ρ = 0.44; p = 0.02), BnMn (ρ = 0.44; p < 0.01), and MnCEITOT (ρ = 0.44; p < 0.01). In adjusted regression models, MnCEI16 was significantly associated with BnMn (β = 0.03; 95% confidence interval = 0.001, 0.05); no other biomarkers were associated with MnCEI. This suggests BnMn may be a useful biomarker of the previous 16 years of Mn exposure, but larger studies are recommended.
Using microRNA Networks to Understand Cancer
Authors: Dragomir Mihnea , Mafra Ana Carolina P. , Dias Sandra M. G. , Vasilescu Catalin , Calin George A.
Published: June 2018

Human cancers are characterized by deregulated expression of multiple microRNAs (miRNAs), involved in essential pathways that confer the malignant cells their tumorigenic potential. Each miRNA can regulate hundreds of messenger RNAs (mRNAs), while various miRNAs can control the same mRNA. Additionally, many miRNAs regulate and are regulated by other species of non-coding RNAs, such as circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs). For this reason, it is extremely difficult to predict, study, and analyze the precise role of a single miRNA involved in human cancer, considering the complexity of its connections. Focusing on a single miRNA molecule represents a limited approach. Additional information could come from network analysis, which has become a common tool in the biological field to better understand molecular interactions. In this review, we focus on the main types of networks (monopartite, association networks and bipartite) used for analyzing biological data related to miRNA function. We briefly present the important steps to take when generating networks, illustrating the theory with published examples and with future perspectives of how this approach can help to better select miRNAs that can be therapeutically targeted in cancer.
Syntheses, Crystal Structures, and Antitumor Activities of Copper(II) and Nickel(II) Complexes with 2-((2-(Pyridin-2-yl)hydrazono)methyl)quinolin-8-ol
Authors: Yang Qi-Yuan , Cao Qian-Qian , Qin Qi-Pin , Deng Cai-Xing , Liang Hong , Chen Zhen-Feng
Published: June 2018

Two transition metal complexes with 2-((2-(pyridin-2-yl)hydrazono)methyl)quinolin-8-ol (L), [Cu(L)Cl2]2 (1) and [Ni(L)Cl2]·CH2Cl2 (2), were synthesized and fully characterized. Complex 1 exhibited high in vitro antitumor activity against SK-OV-3, MGC80-3 and HeLa cells with IC50 values of 3.69 ± 0.16, 2.60 ± 0.17, and 3.62 ± 0.12 μM, respectively. In addition, complex 1 caused cell arrest in the S phase, which led to the down-regulation of Cdc25 A, Cyclin B, Cyclin A, and CDK2, and the up-regulation of p27, p21, and p53 proteins in MGC80-3 cells. Complex 1 induced MGC80-3 cell apoptosis via a mitochondrial dysfunction pathway, as shown by the significantly decreased level of bcl-2 protein and the loss of Δψ, as well as increased levels of reactive oxygen species (ROS), intracellular Ca2+, cytochrome C, apaf-1, caspase-3, and caspase-9 proteins in MGC80-3 cells.
Linoleic Acid Attenuates the Toxic Dose of Bupivacaine-Mediated Reduction of Vasodilation Evoked by the Activation of Adenosine Triphosphate-Sensitive Potassium Channels
Authors: Lee Soo Hee , Kang Dawon , Ok Seong-Ho , Kwon Seong-Chun , Kim Hyun-Jin , Kim Eun-Jin , Hong Jeong-Min , Kim Ji-Yoon , Bae Sung Il , An Seungmin , Sohn Ju-Tae
Published: June 2018

The goal of this study was to investigate the effect of lipid emulsion on a toxic dose of local anesthetic-mediated reduction of vasodilation evoked by the ATP-sensitive potassium (KATP) channel agonist levcromakalim. The effect of lipid emulsion (LE) and linoleic acid on the local anesthetic-mediated reduction of vasodilation and membrane hyperpolarization evoked by levcromakalim was assessed in isolated endothelium-denuded vessels (rat aorta and mesenteric artery) and aortic vascular smooth muscle cells. The effect of LE and linoleic acid on KATP channel activity in transfected HEK-293 cells was investigated, as was the effect of LE on bupivacaine concentration. The efficacy of LE in attenuating the local anesthetic-mediated reduction of vasodilation evoked by levcromakalim was correlated with the lipid solubility of the local anesthetic. Linoleic acid attenuated the bupivacaine-mediated reduction of vasodilation evoked by levcromakalim. LE decreased the bupivacaine-mediated reduction of membrane hyperpolarization evoked by levcromakalim but did not significantly alter the mepivacaine-mediated reduction. LE and linoleic acid both reversed the bupivacaine-mediated decrease of KATP activity and enhanced KATP activity. LE decreased the bupivacaine concentration. Linoleic acid may be the major contributor to LE-induced attenuation of bupivacaine-mediated reduction of vasodilation evoked by levcromakalim via the direct activation of KATP channels and indirect effects.
More Compact Orthogonal Drawings by Allowing Additional Bends †
Authors: Jünger Michael , Mutzel Petra , Spisla Christiane
Published: June 2018

Compacting orthogonal drawings is a challenging task. Usually, algorithms try to compute drawings with small area or total edge length while preserving the underlying orthogonal shape. We suggest a moderate relaxation of the orthogonal compaction problem, namely the one-dimensional monotone flexible edge compaction problem with fixed vertex star geometry. We further show that this problem can be solved in polynomial time using a network flow model. An experimental evaluation shows that by allowing additional bends could reduce the total edge length and the drawing area.
Effect of Shear Stress on Isothermal Crystallization Behavior of CaO-Al2O3-SiO2-Na2O-CaF2 Slags
Authors: Gu Shaopeng , Wen Guanghua , Ding Zequan , Tang Ping , Liu Qiang
Published: June 2018

How to coordinate the contradiction between lubrication and heat transfer in the peritectic steel casting process is the key technical difficulty in preparing mold fluxes. The mold fluxes that are required for casting are subjected to the shear stress generated by mold oscillation and slab movement, which affects the crystallization performance of slags. The quantitative effect of slags’ crystallization performance by shear stress is studied to develop a low-basicity and high-crystallization mold flux to solve the above problem. The results show that the crystallization kinetic condition is promoted, and the crystallization activation energy is reduced by the shear stress, which leads to an increase in the crystallization temperature. Concurrently, the crystal size is reduced. However, the shear stress has no effect on the crystalline phase. The influence of different shear stresses on the crystallization ability of molten slags is related to the crystal nucleation and growth mechanisms. The crystalline fraction of the slag films at 300 rpm (69 s−1) is 44.7%, which is an increase of 17.7% compared with the crystalline fraction of the slag films at 200 rpm (46 s−1). Moreover, the shear stress has little effect on the lubricating properties of the mold fluxes, although the crystallization ability is promoted by the agitation.
Immune system alterations in patients with inflammatory bowel disease during remission
Authors: Šventoraitytė Jurgita , Žvirblienė Aida , Kiudelis Gediminas , Žalinkevičius Rimantas , Žvirblienė Aurelija , Praškevičius Antanas , Kupčinskas Limas , Tamošiūnas Vytas
Published: June 2018

Objective. Perturbed immune homeostasis elicited by misbalanced production of proinflammatory and anti-inflammatory cytokines is characteristic of inflammatory bowel disease. The aim of this study was to evaluate cytokine profile in patients with different forms of inflammatory bowel disease – ulcerative colitis and Crohn’s disease – during clinical remission phase. Material and methods. Production of proinflammatory Th1 cytokines (tumor necrosis factoralpha (TNF-a), interferon-gamma (IFN-g)) and anti-inflammatory Th2 cytokines (interleukin- 10 (IL-10) and interleukin-13 (IL-13)) was analyzed in peripheral blood mononuclear cells of patients with inflammatory bowel disease (9 with ulcerative colitis and 9 with Crohn’s disease) and control subjects (n=11) by enzyme-linked immunosorbent assay (two-site ELISA). Results. The results of the study revealed that the level of TNF-a after stimulation with phytohemagglutinin in patients with Crohn’s disease was significantly higher in comparison to both patients with ulcerative colitis and controls (P<0.001 and P<0.01, respectively). The secretion of IFN-g both in patients with Crohn’s disease and ulcerative colitis was lower than that in controls (P=0.05 and P<0.01, respectively), but it normalized after stimulation with phytohemagglutinin. The levels of IL-10 and IL-13 were significantly (P<0.01) higher in patients with Crohn’s disease than in patients with ulcerative colitis and control group before and after stimulation with phytohemagglutinin. Conclusions. The results of our study provide evidence that in patients with inflammatory bowel disease, the imbalance between production of proinflammatory Th1 and anti-inflammatory Th2 cytokines persists even during remission of the disease, and disturbances of immune homeostasis are significantly more expressed in patients with Crohn’s disease than in patients with ulcerative colitis.
Epidural and general anesthesia versus general anesthesia in radical prostatectomy
Authors: Tikuišis Renatas , Miliauskas Povilas , Samalavičius Narimantas , Žurauskas Aleksas , Sruogis Algimantas
Published: June 2018

Induced hypotension with epidural anesthesia influences the intraoperative blood loss in prostate cancer patients undergoing radical prostatectomy. The aim of this study was to evaluate intraoperative blood loss and need of blood transfusions in patients who underwent radical prostatectomy under epidural/general anesthesia and general anesthesia. Two groups were selected: epidural/general anesthesia group (study group, 27 patients) received epidural anesthesia in association with general anesthesia, and general anesthesia group (control group, 27 patients) received general anesthesia alone. Epidural/general anesthesia was performed using 0.5% solution of bupivacaine and maintained by volatile anesthetic sevoflurane. General anesthesia was performed with endotracheal ventilation using sevoflurane and intravenous fentanyl. The present study showed that the mean blood loss in epidural/general anesthesia group was significantly lower in comparison with that of general anesthesia group (740±210 mL versus 1150±290 mL, P<0.001). In addition, less allogeneic blood was transfused in epidural/general anesthesia group: 0.19 blood units transfused versus 0.52 blood units in general anesthesia group (P=0.007). Our study proved that induced hypotension with epidural/general anesthesia reduced intraoperative blood loss and need of allogeneic blood transfusions in cancer patient undergoing open radical prostatectomy.
On Oxidation Resistance Mechanisms at 1273 K of Tungsten-Based Alloys Containing Chromium and Yttria
Authors: Klein Felix , Wegener Tobias , Litnovsky Andrey , Rasinski Marcin , Tan Xiaoyue , Schmitz Janina , Linsmeier Christian , Coenen Jan Willem , Du Hongchu , Mayer Joachim , Breuer Uwe
Published: June 2018

Tungsten (W) is currently deemed the main candidate for the plasma-facing armor material of the first wall of future fusion reactors, such as DEMO. Advantages of W include a high melting point, high thermal conductivity, low tritium retention, and low erosion yield. However, was an accident to occur, air ingress into the vacuum vessel could occur and the temperature of the first wall could reach 1200K to 1450K due to nuclear decay heat. In the absence of cooling, the temperature remains in that range for several weeks. At these temperatures, the radioactive tungsten oxidizes and then volatilizes. Smart W alloys are therefore being developed. Smart alloys are supposed to preserve properties of W during plasma operation while suppressing tungsten oxide formation in case of an accident. This study focuses on investigations of thin film smart alloys produced by magnetron sputtering. These alloys provide an idealistic system with a homogeneous distribution of the elements W, chromium (Cr), and yttrium (Y) on an atomic scale. The recommended composition is W with 12 weight % of Cr and 0.5 weight % of Y. Passivation and a suppression of WO3 sublimation is shown. For the first time, the mechanisms yielding the improved oxidation resistance are analyzed in detail. A protective Cr2O3 layer forms at the surface. The different stages of the oxidation processes up to the failure of the protective function are analyzed for the first time. Using 18O as a tracer, it is shown for the first time that the oxide growth occurs at the surface of the protective oxide. The Cr is continuously replenished from the bulk of the sample, including the Cr-rich phase which forms during exposure at 1273K. A homogenous distribution of yttria within the W-matrix, which is preserved during oxidation, is a peculiarity of the analyzed alloy. Further, an Y-enriched nucleation site is found at the interface between metal and oxide. This nucleation sites are deemed to be crucial for the improved oxidation resistance.
Circular Dichroism in Fluorescence Emission Following the C 1s→π* Excitation and Resonant Auger Decay of Carbon Monoxide
Authors: Pitzer Martin , Schmidt Philipp , Ozga Christian , Hans Andreas , Reiß Philipp , Petrov Ivan D. , Artemyev Anton N. , Ehresmann Arno , Knie André , Demekhin Philipp V.
Published: June 2018

Dichroism in angle-resolved spectra of circularly polarized fluorescence from freely-rotating CO molecules was studied experimentally and theoretically. For this purpose, carbon monoxide in the gas phase was exposed to circularly polarized soft X-ray synchrotron radiation. The photon energy was tuned across the C 1s→π* resonant excitation, which decayed via the participator Auger transition into the CO+ A 2Π state. The dichroic parameter β1 of the subsequent CO+ (A 2Π → X 2Σ+) visible fluorescence was measured by photon-induced fluorescence spectroscopy. Present experimental results are explained with the ab initio electronic structure and dynamics calculations performed by the single center method. Our results confirm the possibility to perform partial wave analysis of the emitted photoelectrons in closed-shell molecules.
Mahimbrine A, a Novel Isoquinoline Alkaloid Bearing a Benzotropolone Moiety from Mahonia imbricata
Authors: Zhang Mao-Sheng , Deng Yan , Fu Shao-Bin , Guo Da-Le , Xiao Shi-Ji
Published: June 2018

A novel isoquinoline alkaloid, mahimbrine A, possessing a rare benzotropolone framing scaffold, was isolated from the endemic plant of Mahonia imbricata. Its structure was established on the basis of extensive spectroscopic analysis. A plausible biosynthetic route of mahimbrine A was proposed. Mahimbrine A showed no antimicrobial activity at the concentration of 1 mg/mL.
Phytochemical Composition of the Decoctions of Greek Edible Greens (Chórta) and Evaluation of Antioxidant and Cytotoxic Properties
Authors: Mikropoulou Eleni V. , Vougogiannopoulou Konstantina , Kalpoutzakis Eleftherios , Sklirou Aimilia D. , Skaperda Zoi , Houriet Joëlle , Wolfender Jean-Luc , Trougakos Ioannis P. , Kouretas Dimitrios , Halabalaki Maria , Mitakou Sofia
Published: June 2018

Wild or semi-wild edible greens (chórta) are an integral part of the traditional Greek Mediterranean diet due to their nutritional value, containing various phytonutrients beneficial to human health. Water-based decoctions of chórta are widely consumed in Greek alternative medicine as health promoting agents. This study examined the chemical profile of the decoctions of eight edible plants, Cichorium intybus, C. endivia, C. spinosum, Crepis sancta, Sonchus asper, Carthamus lanatus, Centaurea raphanina, and Amaranthus blitum, by UPLC-ESI-HRMS and HRMS/MS analysis, to determine possibly bioactive constituents. The profiles of the plants from the Asteraceae family are dominated by the presence of phenolic acids and flavonoid derivatives, whereas the A. blitum decoction is rich in triterpene saponins. Interestingly, the Centaurea raphanina decoction was found to be extremely rich in flavanones, particularly in the aglycone pinocembrin. Further phytochemical investigation and fractionation of this extract resulted in the isolation and identification of five compounds: phlorin (1), syringin (2), pinocembrin (3), pinocembroside (4), and pinocembrin-7-O-neohesperidoside (5). The extracts were also tested for their antioxidant and differential cytotoxic activity against tumor cells. C. raphanina was found to be differentially toxic against metastatic tumor cells. In conclusion, we found that Greek edible greens are a rich source of bioactive secondary metabolites and their consumption could contribute to the maintenance of overall health.
Design, Synthesis and Biological Evaluation of 6,7-Disubstituted-4-phenoxyquinoline Derivatives Bearing Pyridazinone Moiety as c-Met Inhibitors
Authors: Liu Xiaobo , Kou Jianlan , Xiao Zhen , Tian Fajuan , Hu Jiayi , Zheng Pengwu , Zhu Wufu
Published: June 2018

Deregulation of the receptor tyrosine kinase mesenchymal epithelial transition factor (MET) has been implicated in several human cancers and is an attractive target for small molecule drug discovery. Herein, a series of 6,7-disubstituted-4-phenoxyquinoline derivatives bearing pyridazinone derivatives were designed, synthesized and evaluated for their enzymatic inhibitory activity against c-Met kinase and cellular potency against A549, HepG2, and MCF-7 cell lines. Eight of them are equal to more active than positive control Foretinib against one or more cell lines and enzyme. The most promising compound 53 showed superior activity to Foretinib, which possessed excellent c-Met kinase inhibition on a singledigital nanomolar level (IC50 = 0.6 nM), and cancer cells of A549 (IC50 = 0.003 µM), HepG2 (IC50 = 0.49 µM) and MCF-7 cells (IC50 = 0.006 µM). The result of AO single staining indicated that compound 53 could induce remarkable apoptosis of HepG2 cell.
What Characterizes the Polymodal Media of the Mobile Phone? The Multiple Media within the World’s Most Popular Medium
Authors: Hilbert Martin , Aravindakshan Ashwin
Published: June 2018

While the mobile phone is the world’s most popular media device, it is actually not one single medium, but is effectively used as a different medium by different user groups. The article characterizes polymodal differences in mobile apps usage among different user groups, including gender, education, occupation, screen size, and price. We monitored the complete app usage of 10,725 smartphone users for one month each (56 million sessions, recording almost 1 million hours). Our key contribution consists in developing and analyzing a theoretical framework to classify the over 16,000 apps used into five categories. Exploring nine research questions we provide a broad characterization by asking who, with which characteristics, uses which kinds of apps in what extensity and intensity? For example, it is not the young and high occupational grades that use the mobile phone as a human-to-machine computer (including gaming and artificial intelligence tools). Large screen size is related to extensive long sessions, while a small screen size is related to intensive frequent usage. The results go beyond providing ample empirical evidence for the inherently polymodal nature of the mobile phone, but also proposes a framework on how to deal with it analytically.
Regression Model to Predict the Higher Heating Value of Poultry Waste from Proximate Analysis
Authors: Qian Xuejun , Lee Seong , Soto Ana-maria , Chen Guangming
Published: June 2018

Improper land application of excess poultry waste (PW) causes environmental issues and other problems. Meanwhile there is an increasing trend of using PW as an alternative energy resource. The Higher Heating Value (HHV) is critical for designing and analyzing the PW conversion process. Several proximate-based mathematical models have been proposed to estimate the HHV of biomass, coal, and other solid fuels. Nevertheless, only a small number of studies have focused on a subclass of fuels, especially for PW. The aim of this study is to develop proximate-based regression models for an HHV prediction of PW. Sample data of PW were collected from open literature to develop regression models. The resulting models were then validated by additional PW samples and other published models. Results indicate that the most accurate model contains linear (all proximate components), polynomial terms (quadratic and cubic of volatile matter), and interaction effect (fixed carbon and ash). Moreover, results show that best-fit regression model has a higher R2 (91.62%) and lower estimation errors than the existing proximate-based models. Therefore, this new regression model can be an excellent tool for predicting the HHV of PW and does not require any expensive equipment that measures HHV or elemental compositions.
Rub-Impact Fault Diagnosis Using an Effective IMF Selection Technique in Ensemble Empirical Mode Decomposition and Hybrid Feature Models
Authors: Prosvirin Alexander E. , Islam Manjurul , Kim Jaeyoung , Kim Jong-Myon
Published: June 2018

The complex nature of rubbing faults makes it difficult to use traditional signal analysis methods for feature extraction. Various time-frequency analysis approaches based on signal decomposition, such as empirical mode decomposition (EMD) and ensemble EMD (EEMD), have been widely utilized recently to analyze rub-impact faults. However, traditional EMD suffers from “mode-mixing”, and in both EMD and EEMD the relevance of the extracted components to rubbing processes must be determined. In this paper, we introduce a new informative intrinsic mode function (IMF) selection method for EEMD and a hybrid feature model for diagnosing rub-impact faults of various intensities. Our method uses a novel selection procedure that combines the degree-of-presence ratio of rub impact and a Kullback–Leibler divergence-based similarity measure into an IMF quality metric with adaptive threshold-based selection to pick the meaningful signal-dominant modes. Signals reconstructed using the selected IMFs contained explicit information about the rubbing faults and are used for hybrid feature extraction. Experimental results demonstrated that the proposed approach effectively defines meaningful IMFs for rubbing processes, and the presented hybrid feature model allows for the classification of rub-impact faults of various intensities with good accuracy.
Coumarin Probe for Selective Detection of Fluoride Ions in Aqueous Solution and Its Bioimaging in Live Cells
Authors: Chansaenpak Kantapat , Kamkaew Anyanee , Weeranantanapan Oratai , Suttisintong Khomson , Tumcharern Gamolwan
Published: June 2018

We have synthesized novel coumarin-based fluorescent chemosensors for detection of fluoride ions in aqueous solution. The detection mechanism relied on a fluoride-mediated desilylation triggering fluorogenic reaction and a strong interaction between fluoride and the silicon center. In this work, the hydroxyl-decorated coumarins containing oxysilyl moiety have been synthesized through the aldehyde-functionalized coumarins. The optical responses toward fluoride, as well as aqueous stability studies of both aldehyde and hydroxyl functionalized coumarins, have been investigated. Due to the highest fluorescence enhancement upon the addition of fluoride and good stability in aqueous solution, the hydroxyl-decorated coumarin connected with the bulky tert-butyldiphenyloxysilyl group (-OSitBuPh2) has been selected for further investigation of its potential as a fluoride sensor. This hydroxyl-decorated coumarin can selectively sense fluoride ions in aqueous media (contain 0.8% MeCN) with desirable response times (40 min). The limit of detection of this compound was determined as 0.043 ppm, satisfying the standard fluoride level (0.7 ppm) in drinking water recommended by U.S. Department of Health and Human Services. The application of this silyl-capped coumarin derivative for fluoride analysis in collected water samples displayed satisfactory analytical accuracy (<5% error). Finally, this compound was successfully employed in fluorescence bioimaging of fluoride ions in human liver cancer cells, indicating its excellent cell permeability, ability to retain inside the living cells, and good stability under physiological conditions.
Vibration of a Rotating Micro-Ring under Electrical Field Based on Inextensible Approximation
Authors: Yu Tao , Kou Jiange , Hu Yuh-Chung
Published: June 2018

The problem of vibrations of rotating rings has been of interest for its wide applications in engineering, such as the vibratory ring gyroscopes. For the vibratory ring gyroscopes, the vibration of a micro ring is usually actuated and sensed by means of electrostatics. The analytical models of electrostatic microstructures are complicated due to their non-linear electromechanical coupling behavior. Therefore, this paper presents for the first time the free vibration of a rotating ring under uniform electrical field and the results will be helpful for extending our knowledge on the problem of vibrations of rotating rings, helping the design of vibratory ring gyroscopes, and inspiring the feasibilities of other engineering applications. An analytical model, based on thin-ring theory, is derived by means of energy method for a rotating ring under uniformly distributed electrical field. After that, the closed form solutions of the natural frequencies and modes are obtained by means of modal expansion method. Some valuable conclusions are made according to the results of the present analytical model. The electrical field causes not only an electrostatic force but also an equivalently negative electrical-stiffness. The equivalent negative electrical-stiffness will reduce either the natural frequencies or critical speeds of the rotating ring. It is known that the ring will buckle when its rotational speed equals its natural frequencies. The introduction of electrical field will further reduce the buckling speeds to a value less than the natural frequencies. The rotation effect will induce the so-called traveling modes, each one travels either in the same direction as the rotating ring or in the opposite direction with respect to stationary coordinate system. The electrical field will reduce the traveling velocities of the traveling modes.
Resettlement of Northern Muslims: A Challenge for Sustainable Post-War Development and Reconciliation in Sri Lanka
Authors: Yusoff Mohammad Agus , Sarjoon Athambawa , Mohd Zain Zawiyah
Published: June 2018

This study drew on important insights from a quarter-century history of forcefully evicted Muslims in Sri Lanka’s northern province by examining the nature of their displaced life and their permanent resettlement in their traditional villages, particularly in the post-civil war context. Reviewing the literature and primary sources, this paper argues that the forceful eviction of northern Muslims was unfortunate and the persistent sidetracking of their permanent resettlement violated their right to live in their traditional villages. Successive governments have failed to propose a sustainable mechanism to resettle these Muslims as part of the resettlement plans. Post-war resettlement initiatives hardly considered the permanent resettlement of these Muslims in their traditional villages. In addition, the issue of resettling northern Muslims became highly contested due to lack of proper policies and plans of the government authorities, as well as moral and institutional support from the Tamil community and their polity, opposition, and criticisms from the Sinhalese-Buddhist nationalist forces, and fragmentation within Muslim politics, together with the protracted nature of the displacement. This study suggested that the continued neglect of their resettlement would challenge the sustainability of post-war development and ethnic reconciliation in Sri Lanka.
Reliable Autonomous Production Systems: Combining Industrial Engineering Methods and Situation Awareness Modelling in Critical Realist Design of Autonomous Production Systems
Authors: Fox Stephen
Published: June 2018

Autonomous production needs to be reliable. Outputs from reliable production systems consistently conform to performance requirements. By contrast, outputs from unreliable production systems often do not conform to performance requirements. Unreliable production can lead to accidents, rework, scrap, loss of good will, etc. In this communication paper, comparative analyses are provided of work characteristics in the manufacturing and construction industries, which affect opportunities for reliable high-level autonomous production systems. Analyses indicate that there are strong opportunities and weak opportunities for reliable high-level autonomous production systems in these industries. In the strongest opportunities, there is repeated work certainty; the composition of work involves few materials/parts that have little variation; and work is carried out in settings that require no additional engineering to facilitate reliable autonomous production. In the weakest opportunities, work settings require extensive additional engineering; the composition of work involves many materials/parts that have lots of variation; the work to be done is not certain until completion and then it is never repeated. It is explained that when seeking to improve weak opportunities for reliable high-level autonomous production systems, industrial engineering methods and situation awareness modelling can be combined within a critical realist framework in order to address challenges in work setting, composition and uncertainty.
The Bacteriophage T4 MotB Protein, a DNA-Binding Protein, Improves Phage Fitness
Authors: Patterson-West Jennifer , Arroyo-Mendoza Melissa , Hsieh Meng-Lun , Harrison Danielle , Walker Morgan M. , Knipling Leslie , Hinton Deborah M.
Published: June 2018

The lytic bacteriophage T4 employs multiple phage-encoded early proteins to takeover the Escherichia coli host. However, the functions of many of these proteins are not known. In this study, we have characterized the T4 early gene motB, located in a dispensable region of the T4 genome. We show that heterologous production of MotB is highly toxic to E. coli, resulting in cell death or growth arrest depending on the strain and that the presence of motB increases T4 burst size 2-fold. Previous work suggested that motB affects middle gene expression, but our transcriptome analyses of T4 motBam vs. T4 wt infections reveal that only a few late genes are mildly impaired at 5 min post-infection, and expression of early and middle genes is unaffected. We find that MotB is a DNA-binding protein that binds both unmodified host and T4 modified [(glucosylated, hydroxymethylated-5 cytosine, (GHme-C)] DNA with no detectable sequence specificity. Interestingly, MotB copurifies with the host histone-like proteins, H-NS and StpA, either directly or through cobinding to DNA. We show that H-NS also binds modified T4 DNA and speculate that MotB may alter how H-NS interacts with T4 DNA, host DNA, or both, thereby improving the growth of the phage.
Multiple Photographs of a Perspective Scene Reveal the Principles of Picture Perception
Authors: Erkelens Casper J.
Published: June 2018

A picture is a powerful and convenient medium for inducing the illusion that one perceives a three-dimensional scene. The relative invariance of picture perception across viewing positions has aroused the interest of painters, photographers, and visual scientists. This study explores variables that may underlie the invariance. It presents a computational analysis of distances and directions in sets of two photographs of perspective scenes taken from different camera positions. Focal lengths of the lens and picture sizes are chosen such that the sizes of one of the familiar objects are equally large in both photographs. The selected object is perceived at the same distance in both photographs, independent of viewing distance, showing that pictorial distance is fully determined by angular size of the object. Pictorial distance is independent of camera position, focal length of the lens, and picture size. Distances and directions of pictorial objects are computed as a function of viewing distance, and compared with distances and directions of the physical objects as a function of camera position. The computations show that ratios between pictorial distances, directions, and angular sizes of objects in a photograph are constant, as a function of viewing distance. The constant ratios are proposed as the reason for invariance of picture perception over a range of viewing distances. Reanalysis of distance judgments obtained from the literature shows that perspective space, previously proposed as the model for visual space, is also a good model for pictorial space. The geometry of pictorial space contradicts some conceptions about picture perception.
Does peak expiratory flow measured sitting differ from that measured standing? A cross-over study in primary care in Barbados
Authors: Adams O Peter , Mangera Khatija AS , Hambleton Ian R , Morris Euclid H , Paul-Charles Joanne L
Published: June 2018

Background

Several authorities recommend measuring peak expiratory flow (PEF) standing. Limited evidence suggests that PEF obtained sitting is similar in magnitude but there are no studies in African populations.

Aim

To determine in adults aged 18–60 years if PEF measured sitting differs from that measured standing.

Design & setting

Crossover design with alternating position of initial measurement in people attending primary care clinics in Barbados.

Method

Quota sampling by age, sex, and clinic of adults aged 18–60 years was done and an interviewer-administered questionnaire was completed. PEF sitting and standing was measured with an European Union (EU) scale Mini-Wright® meter. The highest of three readings in each position was used and the difference in means tested for significance using the paired sample t-test.

Results

Characteristics of the 199 participants were 44% male; 96.5% of African descent; mean age 37 years (standard deviation [SD] 12.8); 22% with an asthma diagnosis; 23% tobacco users; and 22% marijuana users. Mean PEF standing was 438.4 versus 429.7 lmin–1 sitting, mean difference 8.7 (95% confidence interval [CI] = 3.6 to 13.8). For men, mean PEF standing was 518.7 versus 506.3 lmin–1 sitting, mean difference 12.4 (95% CI = 3.3 to 21.5). For women, mean PEF was 374.7 standing versus 368.9 lmin–1 sitting, mean difference 5.8 (95% CI = 0.11 to 11.5). A Bland-Altman plot accounting for trend and a Lin’s correlation coefficient of 0.935 demonstrated good agreement between standing and sitting PEF.

Conclusion

PEF measurements are reduced when performed sitting compared to standing. The difference is small and unlikely to alter clinical management in most cases.
Kepler-503b: An Object at the Hydrogen Burning Mass Limit Orbiting a Subgiant Star
Authors: Cañas Caleb I. , Bender Chad F. , Mahadevan Suvrath , Fleming Scott W. , Beatty Thomas G. , Covey Kevin R. , Lee Nathan De , Hearty Fred R. , García-Hernández D. A. , Majewski Steven R. , Schneider Donald P. , Stassun Keivan G. , Wilson Robert F.
Published: June 2018

Using spectroscopic radial velocities with the Apache Point Observatory Galaxy Evolution Experiment (APOGEE) instrument and Gaia distance estimates, we demonstrate that Kepler-503b, currently considered a validated Kepler planet, is in fact a brown-dwarf/low-mass star in a nearly circular 7.2-day orbit around a subgiant star. Using a mass estimate for the primary star derived from stellar models, we derive a companion mass and radius of 0.075 ± 0.003 M
⊙ (78.6 ± 3.1 M
Jup) and

(

R
Jup), respectively. Assuming that the system is coeval, the evolutionary state of the primary indicates the age is ∼6.7 Gyr. Kepler-503b sits right at the hydrogen-burning mass limit, straddling the boundary between brown dwarfs and very low-mass stars. More precise radial velocities and secondary eclipse spectroscopy with the James Webb Space Telescope (JWST) will provide improved measurements of the physical parameters and age of this important system to better constrain and understand the physics of these objects and their spectra. This system emphasizes the value of radial velocity observations to distinguish a genuine planet from astrophysical false positives, and is the first result from the Sloan Digital Sky Survey (SDSS)-IV monitoring of Kepler planet candidates with the multi-object APOGEE instrument.
Forced Diuresis and Expedient Blood Pressure Control in the Management of Quetiapine Induced Neuroleptic Malignant Syndrome: A Case Report
Authors: Aquilina Neville , Bugeja Vincent
Published: June 2018

BACKGROUND: This case report intends to highlight the importance of safeguarding renal function from rhabdomyolysis in neuroleptic malignant syndrome (NMS) by concomitant administration of parenteral fluids at a high rate together with high doses of parenteral loop diuretics (we utilised 6 mg bumetanide daily) and tailed over a few days, in order to preserve glomerular/renal medullary perfusion and nephron function.CASE REPORT: This case describes an elderly lady previously diagnosed with Lewy body dementia who had been started on low dose quetiapine a few days previously and presented with an acute 24 – 48 hour onset of fever, generalised stiffness, rapidly becoming uncommunicable and with high blood pressure. Haemoglobinuria was present prompting intravenous treatment with labetalol to address the BP, whereas rapid isotonic saline fluid infusions together with intravenous high dose bumetanide were instituted to safeguard the kidneys against damage due to nephron deposition, both from haemoglobinuria as well as possibly myoglobin from rhabdomyolysis. A working diagnosis of the neuroleptic malignant syndrome with secondary malignant hypertension was made, and the quetiapine withdrawn. Blood pressure was after that subsequently controlled on amlodipine, and the haemoglobinuria quickly settled within 24 hours, with large amounts of dilute urine being passed on account of the forced diuresis. The fact that renal function and creatinine kinase remained normal is testimony to how these expedient measures averted progression to both rhabdomyolysis and renal failure in this case, thereby ameliorating prognosis.CONCLUSION: The patient was kept on infused fluids with maintenance bumetanide alone, achieving a full clinical recovery within the following 3 days.