bluuebunny/crossref_metadata_2025 huggingface dataset:
Khmer Semantic Search Engine (KSE): Digital Information Access and Document Retrieval
Authors: THUON NIMOL
Published: September 2024

The search engine process is crucial for document content retrieval. For Khmer documents, an effective tool is needed to extract essential keywords and facilitate accurate searches. Despite the daily generation of significant Khmer content, Cambodians struggle to find necessary documents due to the lack of an effective semantic searching tool. Even Google does not deliver high accuracy for Khmer content. Semantic search engines improve search results by employing advanced algorithms to understand various content types. With the rise in Khmer digital content—such as reports, articles, and social media feedback—enhanced search capabilities are essential. This research proposes the first Khmer Semantic Search Engine (KSE), designed to enhance traditional Khmer search methods. Utilizing semantic matching techniques and formally annotated semantic content, our tool extracts meaningful keywords from user queries, performs precise matching, and provides the best matching offline documents and online URLs. We propose three semantic search frameworks: semantic search based on a keyword dictionary, semantic search based on ontology, and semantic search based on ranking. Additionally, we developed tools for data preparation, including document addition and manual keyword extraction. To evaluate performance, we created a ground truth dataset and addressed issues related to searching and semantic search. Our findings demonstrate that understanding search term semantics can lead to significantly more accurate results.
Accumulation of S-adenosyl-L-homocysteine impairs methylation and development in Saccharomyces cerevisiae and Drosophila melanogaster
Authors: Brunner Markus S. , Habisch Hansjörg , Hafner Jutta , Mack Maximilian , Novosiadla Zoriana , Wolinski Heimo , Rechberger Gerald N. , Madl Tobias , Pertschy Brigitte , Kühnlein Ronald P. , Tehlivets Oksana
Published: September 2024

S-adenosyl-L-homocysteine (SAH), the product inhibitor of S-adenosyl-L-methionine (SAM)-dependent methyltransferases, and its degradation product homocysteine (Hcy) are evolutionarily conserved master regulators of methylation metabolism. They can affect more than 200 methyltransferases in humans interfering with numerous methylation-dependent processes. Hyperhomocysteinemia (HHcy), characterized by elevated Hcy levels in the blood, is an independent risk factor for atherosclerosis and a strong predictor of cardiovascular mortality, yet, the mechanisms by which elevated Hcy contributes to pathological consequences remain poorly understood. Here we developed a Drosophila dietary HHcy model, as well as a genetic SAH hydrolase (SAHH) in vivo knockdown model and compared them to corresponding yeast models to reveal evolutionarily conserved developmental effects and methylation pattern changes. Feeding Drosophila a Hcy-containing diet or growing yeast on Hcy-supplemented medium similarly to genetically blocking SAH degradation leads to SAH accumulation, developmental delay and growth defects. Furthermore, Hcy supplementation or genetically induced SAH accumulation leads to impaired protein and phospholipid (PL) methylation in both model organisms. While total protein arginine methylation is significantly decreased in wild type yeast grown in presence of Hcy or in the ∆sah1 yeast mutant, it is unaffected in Drosophila larvae raised on Hcy-supplemented diet. In contrast, histone methylation is affected in Drosophila and yeast, but exhibited differences in responses of particular histone methylation sites. Similarly, PL methylation was reduced in both organisms and resulted in deregulation of lysoPL metabolism suggesting PL remodeling. Functional characterization of evolutionary conserved Hcy/SAH-dependent methylation targets in Drosophila and yeast will reveal mechanisms of SAH toxicity which may be operative in HHcy-associated human pathologies.
Public management of scientists’ potential as a source of economic development: A bibliometric analysis
Authors: Kangalakova Dana , Satpayeva Zaira , Nurkenova Makpal , Suleimenova Arailym
Published: September 2024

Particular hopes have always been placed on the potential of scientists because they can act as a driving force for effective government. Understanding the importance of scientists ensured progress and prosperity for leading civilizations. This study aims to identify an evolutionary-chronological, geographical, and contextual scientific landscape of the development and management of the potential of scientists through a comprehensive bibliometric analysis. Initially, 5619 publications in the Scopus database were selected from 1957 to 2023. The evolution of knowledge about the importance of public administration of scientific personnel began in 1957 and reached its peak in 2019. Authors from the USA, Great Britain, and Australia have published more about the significance of managing the potential of scientific personnel, and strong schools of knowledge about scientific personnel are concentrated in the USA, France, Canada, and Australia. The analysis of the research’s conceptual orientation shows that publications in environmental and social sciences dominate this sphere. In addition, the bibliometric analysis results show that public management of scientific personnel will bring benefits such as effective government policy decisions, increased innovation activity, commercialization, and improvement of the population’s social life. The results of this study lay the foundation for future research that should improve the management of scientific personnel’s potential.
AcknowledgmentsThis study is supported by the Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan (AP19579256 “Mechanisms for empowering women in scientific activity in the interests of the development of the innovative economy of Kazakhstan”, 2023–2025).
Effect of Remote Electronic Voting on Voter Turnout in Russia in 2021–2023
Authors: Fedorov Vladislav
Published: September 2024

Remote electronic voting, also known as i-voting, transforms elections in Russia and worldwide, opening up new opportunities for the state and society to move from agent-object to subject-to-subject relations. However, the impact of i-voting on political processes, especially at the regional level, is yet to be studied by social sciences. The author analyzed the effect of remote electronic voting on voter turnout at the federal and regional elections in Russia in 2021–2023 and compared them with the turnout that involved traditional means of voting. The cross-regional and cross-temporal analysis of electoral statistics partially proved that remote electronic voting as an additional voting channel increased voter turnout at the federal level. The Russian electronic voting network appeared to be an efficient state operator in 2021–2023. However, the increase in voter turnout was lower in the regions. If subjected to strict public control, remote electronic voting can justifiably considered as an effective form of conventional political participation.
Non-Profit Organizations and Associations in Public Commissions Under Chief Bureaus of Sociomedical Assessment in Different Regions of Russian Federation
Authors: Fomina Tat'yana , Shchanina EKATERINA
Published: September 2024

The system of medical and social expertise in Russia is three years old. Involvement of public and the non-profit sector have resulted in a significant number of representatives of specialized non-profit organizations in public commissions under the chief bureaus of sociomedical assessment. Patient-oriented non-profit organizations introduce new guidelines into the system, e.g., a more rapid adjustment of medical and social expertise to the needs of the target group. Nevertheless, the quality and accessibility of sociomedical assessment services remain a prospective research field. The article describes the involvement of non-profit organizations and associations in the activities of public commissions under the chief bureaus of medical and social assessment. The research was part of the project on Public participation in improving the sociomedical assessment in the Russian Federation: involvement, development, and monitoring. The research data were obtained from structured interviews with representatives of public commissions at the chief bureaus of sociomedical assessment and focus group interviews. Two groups included 12–15 representatives of patient non-profit organizations involved in public commissions. The resulting analysis of the composition of public commissions for 2018–2022 revealed the following facts. Patient non-profit organizations were the most significant group among public commissions are representatives of patient non-profit organizations (34.1%). Representatives of the chief bureaus of sociomedical assessment tended to leave: 12% in 2018 and 4% in 2022. The wide representation of non-profit organizations indicated the public orientation of the commissions. The most active participants were those non-profit organizations that consulted citizens, thus improving the effectiveness of the commissions. The factors that affected the activity of public commissions were connected with their employees, i.e., their awareness, goal understanding, motivation for public work, involvement, and workflow management. Patient non-profit organizations participated in the work of public commissions in following types: presence, representation, and goal achievement. The current development vector is the shift to the type of goal achievement.
Do Industrial Jobs Have Good Prospects? A Sociological Survey of School Students from the Ural
Authors: Shalagina Elena , Shihova Ol'ga
Published: September 2024

Education organizations need to reconceptualize their career guidance activities in the context of global digitalization and technological development. The current changes on the labor market make it necessary to study schoolchildren’s ideas about industrial jobs. Professional preferences of school students usually depend on their age and reflect new success models, i.e., the so-called fluid life trajectories. This research featured the attitudes of school students to industrial professions with their attractiveness and unattractiveness in terms of future career plans. The online survey covered 7628 students of 9th and 11th grades, a semi-formalized expert interview with young employees under 35 (n = 204) and a focus group of ten young employees of Kalinin Machine-Building Plant, Yekaterinburg. Theschool students based their career attitudes on the following assumptions. First, they lacked awareness of scientific and technological development in engineering and, as a result, considered this profession unpopular. Second, they did not perceive factory professions as prestigious because of the Soviet model of a factory worker as a servant to the factory.The unattractive features of a factory-related job were described as unhealthy, difficult, with no career prospects, and monotonous. The only attractive feature was stability. Engineering received a more favorable description, i.e., promising, diverse, well-paid, and challenging. The concept of a factory worker was shaped by the experience of parents: 50% of school students had very outdated knowledge of industrial production.
Causes and Factors of Changes in Consumer Behavior
Authors: Moskovceva Larisa , Yazykova Svetlana , Shaposhnikova Irina , Orlova Alina
Published: September 2024

Public needs and tastes change due to global trends and personal transformations. In time of change, producers look for new ways to attract consumers. The research featured global trends that affect the behavior of Russian consumers, as well as the factors that altered the change in the structure and patterns of Russian consumption market during the pandemic of COVID-19. The authors analyzed global trends in consumer behavior in the period preceding the pandemic and studied the factors that affected the behavior of Russian consumers during the pandemic. They traced the evolution of consumer behavior patterns to identify effective tools that could help the market to meet the needs of the population. The research is relied on information from open sources, processed with the help of standard research methods and economic analysis. Unstable economy, poor economic well- being, and general uncertainty push people to the model of crisis consumption, which happened during the pandemic. The overconsumption in the acute phase of COVID-19 gradually gave way to rational choice and responsible consumption. Digital technologies that thrived during the pandemic shaped a new vector and patterns of consumer behavior that developed as part of pre-COVID global trends and during the pandemic. The article also describes tools that are able to improve the quality of public consumption.
Regional Economic Security Risks during Pandemic Uncertainty
Authors: Hashir Bella , Plyasova Svetlana , Usanov Alexander , Ioda Yuliya
Published: September 2024

The article describes economic insecurity that occurs in a time of uncertainty and affects human development and social well-being. The authors defined indicators to analyze, identified and justified the vector of state policy, and studied the socio-economic issues of territorial development as a source of risks. The dataunder analysis were obtained from public sources, systematized, and subjected to economic analysis using the methods of absolute, relative, and mean values, as well as graphical and logical methods. The period under study covered 2018–2022, which made it possible to assess the impact of the uncertainty caused by the COVID 19 pandemic on the Russian federal districts by analyzing indicators of economic security. The research revealed economic and social risks, as well as the state policy in leveling them across the country. The pandemic triggered economic uncertainty, which destabilized the social well-being and development opportunities of the population in the regions. The current state policy provides long-term transformations and allows the population to adapt to changes.
Rank Aggregation Methods and Tools in Genomic Data Analysis
Authors: Zou Wenping , Mwesigwa Savannah , Hosseini Sayed-Rzgar , Zhao Zhongming
Published: September 2024

Rank aggregation (RA) is the process of consolidating disparate rankings into a single
unified ranking. It holds immense potential in the field of genomics. RA has applications in diverse
research areas, such as gene expression analysis, meta-analysis, gene prioritization, and biomarker
discovery. However, there are many challenges in the application of the RA approach to biological
data, such as dealing with heterogeneous data sources, rankings of mixed quality, and evaluating the
consolidated rankings. In this review, we present an overview of the existing RA methods with an
emphasis on those that have been tailored to the complexities of genomics research. These encompass
a broad range of approaches, from distributional and heuristic methods to Bayesian and stochastic
optimization algorithms. By examining these techniques, we aim to equip researchers with
the background knowledge needed to navigate the intricacies of RA in genomics data integration
effectively. We review the practical applications to highlight the relevance and impact of RA methods
in advancing genomics research. As the field continues to evolve, we identify open problems
and suggest future directions to enhance the effectiveness of rank aggregation in genomics, by addressing
the challenges related to data heterogeneity, single-cell omics and spatial transcriptomics
data, and the development of clear and consistent evaluation methods. In summary, RA stands as a
powerful tool in genomics research, which can offer deeper insights and more comprehensive data
integration solutions.
Advances in Research on Adropin: Potential Implications for Clinical Diagnosis and Possible Treatment – A Mini-Review
Authors: Berdowska Agnieszka , Berdowska Sylwia
Published: September 2024

:

Adropin is 76-amino acids protein. It was discovered in 2008. Adropin expression was found in the liver, brain, heart, kidneys, pancreas, testis and ovary, umbilical vein, coronary artery endothelial cells, aortic smooth muscle cells and monocytes/macrophages. Adropin is involved in energy balance, and it has an endothelial protective effect. Changes in adropin content have been found in many diseases and disorders, such as obesity, diabetes mellitus type 1 and 2, coronary artery disease, myocardial infarction, rheumatoid arthritis, primary Sjögren's syndrome, multiple sclerosis, nonalcoholic fatty liver disease, polycystic ovary syndrome and preeclampsia. This mini-review focuses on those papers that have potential implications for clinical diagnosis or possible treatment. It can be assumed that adropin can be useful in the diagnosis of certain diseases. It seems to be a promising candidate for the treatment of diabetes, atherosclerosis, polycystic ovary syndrome and diseases of the nervous system associated with cognitive decline.
Unveiling The Applications of Nanoparticles in Cancer Immunotherapy
Authors: Mehra Gulpreet , Singh Pragya , Sharma Nitin
Published: September 2024

Cancer immunotherapy has proven its potential application by enhancing the capacity
of the immune system to destroy cancer cells. However, several challenges, such as non-specific
targeting, variability in clinical response, and therapeutic resistance, are associated with immunotherapy,
making it less efficacious. Nanoparticles (NPs) as a drug delivery system provide
additional advantages during immunotherapy by ensuring targeted delivery of antigens. NPs can
also change the cancer environment through adjuvant delivery, forcing cancer cells to be destroyed.
Here, several applications of NPs are summarized to help enhance the therapeutic values
of immunotherapy through several mechanisms. This article outlines the important developments
and possible applications of NPs to fully realize the promise of cancer immunotherapy, which will
eventually open the door to more personalized and efficient cancer treatments.
Exploring Cannabis sativa L for Anti-Alzheimer Potential: An Extensive Computational Study including Molecular Docking, Molecular Dynamics, and ADMET Assessments
Authors: Nour H. , Yamari I. , Abchir O. , Mounadi N. , Samadi A. , Belaidi S. , Chtita S.
Published: September 2024

Introduction:

Cholinesterase enzymes play a pivotal role in hydrolyzing acetylcholine, a
neurotransmitter crucial for memory and cognition, into its components, acetic acid, and choline. A
primary approach in addressing Alzheimer's disease symptoms is by inhibiting the action of these
enzymes.

Method:

With this context, our study embarked on a mission to pinpoint potential Cholinesterase
(ChE) inhibitors using a comprehensive computational methodology. A total of 49 phytoconstituents derived from Cannabis sativa L underwent in silico screening via molecular docking, pharmacokinetic and pharmacotoxicological analysis, to evaluate their ability to inhibit cholinesterase enzymes. Out of these, two specific compounds, namely tetrahydrocannabivarin and Δ-9-
tetrahydrocannabinol, belonging to cannabinoids, stood out as prospective therapeutic agents
against Alzheimer's due to their potential as cholinesterase inhibitors. These candidates showcased
commendable binding affinities with the cholinesterase enzymes, highlighting their interaction with
essential enzymatic residues.

objective:

Our study aims to pinpoint potential Cholinesterase (ChE) inhibitors derived from Cannabis sativa L using molecular docking, pharmacokinetic, and pharmacotoxicological analysis.

Result:

They were predicted to exhibit greater binding affinities than Rivastigmine and Galantamine. Their ADMET assessments further classified them as viable oral pharmaceutical drugs. They
are not expected to induce any mutagenic or hepatotoxic effects and cannot produce skin sensitization. In addition, these phytoconstituents are predicted to be BBB permeable and can reach the
central nervous system (CNS) and exert their therapeutic effects. To delve deeper, we explored
molecular dynamics (MD) simulations to examine the stability of the complex formed between the
best candidate (Δ-9-tetrahydrocannabinol) and the target proteins under simulated biological conditions. The MD study affirmed that the ligand-ChE recognition is a spontaneous reaction leading to
stable complexes

Conclusion:

Our research outcomes provide valuable insights, offering a clear direction for the
pharmaceutical sector in the pursuit of effective anti-Alzheimer treatments.
Unlocking the Therapeutic Potential of Medicinal Hemp: Insights into Pharmacokinetics and Metabolism of Cannabinoids
Authors: Shah Syed Sabir Hussain , Latif Saba , Qureshi Rahmatullah
Published: September 2024

Medicinal hemp or Cannabis (Cannabis sativa L.) is one of the earliest herbs widely
used in traditional medicine by human beings for millions of years. This species was originally
thought to be endemic to Asian countries but has now grown worldwide. It is a dioecious and annual
plant that belongs to the Cannabaceae family. It has a long history of cultivation for food,
intoxicants, hemp medicine, rope, paper, fiber, and oil extraction. Due to its diverse therapeutic
properties, it is legalized in over 50 countries and cultivated as a medicinal and recreational crop.
This review was aimed at collecting information about medicinal cannabis, ranging from traditional
use to commercial utilization. This review article is based on gathering scientific literature
from Google Scholar, Scopus, PubMed, Science Direct, Wiley Online Library, Taylor Francis,
and Springer with 119 documents, including original articles, review articles, books, and thesis
from 1973 to 2024. So far, more than 500 phytochemicals have been identified. Phytocannabinoids
are thought to be the main bioactive ingredients that produce therapeutic benefits. These
are mostly produced or synthesized in secretary cells located inside of glandular trichomes that
are found in the female inflorescence or flowers of hemp crop. Cannabidiol (CBD) has strong
therapeutic potential and is used to cure many fatal diseases. A thorough understanding of the
pharmacokinetics and metabolism of medicinal hemp is vital for tailoring treatment approaches
and minimizing adverse effects. The effect and severity of Cannabidiol (CBD) and tetrahydrocannabinol
(THC) are determined by the route of application and their dose. It can be concluded
that much of the work needs to be done for the validation of ethnobotanical claims by conducting
detailed studies on exploring various phytocannabinoids regarding medicinal use through in vitro
and in vivo activities and the way forward for its commercial utilization.
Spectroscopic Analysis of Nigerian Gem-grade Yellow Garnet Varieties and their Color Differences
Authors: Li Ming , Li Kun , Chen Lingxia , Yu Shengqiang , Fang Qian
Published: September 2024

Background:

Research on yellow garnets of different shades regarding their varieties,
colors, as well as chemical states, and contents of coloring ions is somewhat lacking. Spectroscopic
analyses are expected to enrich the research methods and data on yellow garnets and explore a scientific
path for enhancing their colors.

Methods:

A series of analyses, such as X-ray diffraction, infrared spectroscopy, ultraviolet-visible
spectroscopy, X-ray photoelectron spectroscopy, and electron microprobe analyses, have been performed
on the garnet crystal samples.

Results:

X-ray diffraction analysis and infrared spectral analysis have shown yellow and tawny garnets
to be spessartite garnets; UV–visible spectral analysis has shown the yellow sample to have
stronger absorption peaks at 408, 421, and 430 nm than the tawny sample. Electron microprobe and
X-ray photoelectron spectroscopy analyses have shown both spessartite garnet samples to contain the
same elements, including Si, O, Al, Ca, Mn, and Fe. Among them, the coloring elements, Mn and Fe,
have been found to be identical in terms of type, chemical state, lattice occupancy, and coordination
environment, but with different mass percentages.

Conclusion:

The color differences between yellow-shaded spessartite garnets from Nigeria have not
been found to arise from differences in the types of coloring elements, their valance states, or coordination
environments. Instead, the concentration of coloring ions Mn2+ and Fe2+ has been identified
as the crucial factor. Controlling the concentrations is the key scientific direction for improving the
colors of these yellow-toned spessartite garnets.

conclusion:

The color differences between yellow-shaded spessartite garnets from Nigeria do not arise from differences in the types of coloring elements, their valance states, or coordination environments. Instead, the concentration of coloring ions Mn2+and Fe2+ is identified as the crucial factor. Controlling the concentrations is the key scientific direction for improving the colors of these yellow-toned spessartite garnets.
Recent Advances in Nanobiomaterials for Bone Tissue Engineering
Authors: Darghiasi Seyedeh Farnaz , Naghib Seyed Morteza , Hosseine Mojtaba , Mozafari M. R.
Published: September 2024

Bone tissue engineering has been continuously developing since the concept of “tissue engineering” was introduced. First, this paper, the summarized literature, defines the term of
"Bone Tissue Engineering" and explains the physiology, cells, and ECM of bone. Then, it will
review the bioactivity and osteogenic properties such as osteoconductivity, osteoinductivity, and
osteogenesis. Finally, this paper will introduce polymer-based and ceramic-based biomaterials
that can be used in bone tissue. To be detailed, calcium phosphate, calcium magnesium, and
calcium silicate materials will be explained in the category of nano bioceramics. In addition,
natural, synthetic, and composite polymers will be explained in the category of polymers.
Metal Nanoparticles for Ovarian Cancer Therapy
Authors: Patel Arti , Londhe Swapnali , Saha Sudipta , Patra Chitta Ranjan
Published: September 2024

Background:

Ovarian cancer is the most fatal gynecological cancer, with the highest death rate because of its late diagnosis and recurrence. Owing to the
inherent drawbacks of conventionally available approaches for ovarian cancer treatment, alternative strategies need to be developed. Recently,
nanotechnology-based drug delivery vehicles (polymer, liposome, dendrimers, etc.) have been extensively used in cancer therapy, especially for
ovarian cancer. Among various nanoformulations, metal nanoparticle-based approaches are widely studied for ovarian cancer treatment as they
offer several advantages, such as high therapeutic output, biocompatibility, non-toxicity, non-inflammatory effects, biodegradability, etc.

Objective:

This review aimed to emphasize the advancement of metal-based nanoformulations for ovarían cancer therapy along with toxicological aspects.

Methods:

The information was gathered from many search engines, such as SciFinder, PubMed, and ScienceDirect, to get coverage of suitable research and
compile relevant data about metal nanoparticles for ovarian cancer treatment.

Results:

Investigating metal nanoparticle-based therapies for the treatment of ovarian cancer provides a new direction for future studies.

Conclusion:

This review highlights the anti-cancer activity of metal nanoformulations for ovarian cancer therapy, recent progress, challenges, and future
perspectives in detail, along with the toxicological aspects.
A Review of the Therapeutical Perspective of Phytochemicals in the Treatment of HIV
Authors: Srivastwa Shubham Kumar , Mehra Anuradha , Sangwan Rekha
Published: September 2024

HIV/AIDS is one of the most widespread global diseases. It is caused by the human immunodeficiency
virus (HIV), which leads to the development of acquired immunodeficiency syndrome
(AIDS). In AIDS patients, the immune system progressively weakens, making them vulnerable
to various infections and cancers. The virus can be transmitted through the exchange of bodily
fluids such as blood, semen, vaginal fluid, and breast milk, where HIV can be found in both free
virus particles and infected immune cells. Although drug resistance remains a challenge for
HIV/AIDS treatment, researchers are exploring the use of natural substances in the development of
anti-HIV drugs. Clinical trials based on plant-derived compounds are currently being conducted.
Experimental research suggests that plants may have the potential to treat HIV. However, the identification
of active compounds, testing of extracts, and creation of suitable bioassays are all complex
processes. Natural product scientists face the challenge of separating these complicated extracts into
their active components. Various phytochemicals found in Astragalus membranaceus Bunge, Chelidonium
majus L, Combretum molle (R. Br. ex. G. Don.) Engl& Diels, Dittrichiaviscosa (L.) Greuter,
Helichrysum populifolium, Hoodia gordonii (Masson) Sweet ex Decne, and Hypericumperf, have
been investigated pharmacologically and pharmacokinetically. Further research is needed to optimize
formulations and production in accordance with preclinical safety and efficacy studies.
Advancing Epigenetic and Antioxidant Strategies in Natural Therapeutics Against SARS-CoV-2: A Mini Review of Current Innovations and Future
Directions
Authors: Adrianta Ketut Agus , Siada Nyoman Budiartha , Wibawa Agung Ari Chandra , Wardani I.G.A.A Kusuma , Shantini Suena Ni Made Dharma
Published: September 2024

This review explores the potential of natural products, particularly curcumin and gingerol,
as immune regulators and anti-inflammatory agents in combating SARS-CoV-2 infections via epigenetic
and antioxidant mechanisms. Oxidative stress induced by coronavirus infections can trigger
severe immune responses, such as cytokine storms, often leading to therapy failure. This oxidative
stress is exacerbated by depleted antioxidant defenses. The review examines how natural ingredients
activate endogenous antioxidants through pathways like nuclear factor erythroid 2-related factor 2
(Nrf-2) activation, leading to gene expression changes without altering DNA structure. These changes
enhance cellular defenses against oxidative stress and reduce inflammation, potentially mitigating
the virus's effects. The methodology involved a literature review of scientific articles from databases
such as Google Scholar, Elsevier, Science Direct, Scopus, and Wiley Online Library, focusing on
publications from 2010 to 2023. Data were analyzed using deductive qualitative descriptive techniques,
emphasizing the role of natural compounds in activating antioxidant responses to prevent or
minimize cellular damage caused by COVID-19. The review underscores the significant role of diet
and nutritional intake in supporting the body's antioxidant capacity by activating specific receptors
that influence gene expression related to immune responses and cellular repair mechanisms. Flavonoids
and anthocyanins are highlighted as key compounds in natural products with therapeutic potential
against COVID-19. Overall, this research advocates for further exploration of natural products as
viable options for preventing and treating COVID-19, suggesting that these compounds offer dual
benefits of antiviral activity and immune modulation through epigenetic regulation and antioxidant
support.
Phyto-Active Components Delivered through Lipid Nanodrug Carriers as a Promising Avenue for the Treatment of Alzheimer’s Disease: Their Present Status and Industrial Viability
Authors: Mishra Mr. Abhishek , Sahu Pratap Kumar , Satapathy Bhabani Sankar , Biswal Biswabhusan
Published: September 2024

Introduction:

Present years have witnessed an unprecedented growth of Alzheimer’s
disease (AD) with limited scope for conventional therapeutics. Plant-derived active components
(PACs) are being widely utilized as alternate, compatible, efficacious, eco-friendly strategies to
ameliorate therapeutic benefits in AD while minimizing toxic effects. However, delivery of PACs
in the regular dosage form often faces challenges due to low stability and bioavailability, brainspecific
delivery, dose-related toxic effects, etc., which can be subsided by experimentally fabricated
Lipid Nano Drug Carriers (LNCs). The objective of this study is to provide a comprehensive,
evidence-based review on recent progress in the PACs-loaded lipid nanocarriers (PLNs)-based
therapeutic strategies for AD.

Methods:

For the study implementation, a systematic literature review was carried out from various
scientific potential databases like Scopus, Pubmed, Web of Science, etc., and relevant evidence-
based pre-clinical research data was pooled to draw conclusive outcomes.

Results:

LNCs are treated as promising avenues to effectively deliver various PACs into the brain
due to their high lipophilicity with ultra-micron size and tunable surface features, which make
them eligible to pass through the blood-brain barrier. Both passive and active targeting of PLNs
has been explored to target AD by overcoming the off-target bio delivery problems.

Conclusion:

The review provided updated preclinical study-based data on the potentialities of
PLNs in overcoming AD. Simultaneously, equal weightage was devoted to the issues faced beyond
the laboratory in their successful technology transfer. The study would be beneficial in unveiling
important insights into the implications of PLNs for their futuristic clinical applicability.
Enhancing Anti-Hyperpigmentation Efficacy: A Review on Herbal Nanodelivery System
Authors: Pebriani Ni Luh Gede Wiwin , Mauludin Rachmat , Kurniati Neng Fisheri
Published: September 2024

Hyperpigmentation refers to a condition characterized by excessive skin pigmentation,
leading to darkened areas on the skin. This condition can significantly affect physical appearance
and have adverse effects on emotional and psychological well-being. The use of commercial skinlightening
products for hyperpigmentation therapy often entails significant side effects, prompting
the exploration and development of herbal products as alternative anti-hyperpigmentation agents.
Herbs act as anti-hyperpigmentation agents through various mechanisms, including inhibiting the
expression and activity of tyrosinase, as well as reducing the uptake and distribution of melanosomes.
The advancement of nanoparticle delivery systems represents a significant stride in enhancing
the efficacy of herbal compounds, overcoming the limitations associated with conventional
phytochemical formulations. Herbal plants incorporated into nanoparticle delivery systems demonstrate
superior activity as anti-hyperpigmentation agents compared to their conventional extract
counterparts. Various nanoparticle formulations employed include zinc oxide and gold nanoparticles,
nanovesicles, nanosponges, nanoliposomes, Nanostructured Lipid Carriers (NLC), and Solid
Lipid Nanoparticles (SLN). This narrative review aims to explore natural ingredients, diverse
nanoparticle formulations, and the impacts of nanoparticle delivery of herbs as anti-hyperpigmentation
agents, drawing insights from both preclinical and clinical studies. This review is intended
to provide a foundation for the future development of herbal nanoparticle delivery systems.
A Mini Review on the Opportunities for Membrane Pervaporation Technology for Energy-efficient Removal of Dispersed Oil and Dissolved Hydrocarbons from Produced Water
Authors: Adewole Jimoh K. , Yeneneh Anteneh M. , Oladipo Habeebllah B. , Al Kharusi Asma S.K.
Published: September 2024

:

Produced water is reported to have the largest volume of waste stream associated
with hydrocarbon recovery. It was estimated to increase from 250 million B/D in 2007
to more than 300 million B/D between 2010 and 2012. Market research conducted by
Adroit put the globally produced water treatment market at a value of USD 5.10 billion in
2022. This value is anticipated to be USD 9.80 billion in 2032 at a compound annual
growth rate (CAGR) of 5.80% over the prediction period. Oil and gas companies have
been mandated to comply with the newly enacted environmental regulations that require
extensive treatment of this water before discharge or reuse. The limited quantity of freshwater
resources coupled with the increasing oil and gas production activities has made it
necessary for all stakeholders to look for sustainable management of this water. Presently,
a certain percentage of produced water is reused while the rest is discharged into the ocean.
In both cases, the water needs to be thoroughly treated. The choice of technologies for produced
water treatment depends on numerous factors, such as the chemical composition of
the water and the level of purity that must be attained before disposal, recycling, or re-use.
Some of the technologies used for produced water treatment include physical separation
methods such as gravity, adsorption, filtration, coalescence, cyclones, flotation, centrifuges,
membranes, and oxidation. There are also chemical and biological separation methods.
Contaminants such as small droplets of dispersed oil and dissolved hydrocarbons
(DODHs) are very challenging to remove using the above-listed water treatment technologies.
Moreover, the use of membrane technology has been limited only to the use of reverse
osmosis and membrane filtration for removing salinity, metals, and other inorganics.
This article highlights the opportunities for the use of membrane vapor permeation and
pervaporation for the removal of the small droplets of DODHs, which have been reported
to be very challenging contaminants to remove. The use of 3D printing technology for the
fabrication of membrane materials was reviewed. The 3D membrane development method
can be used to fabricate almost any shape of the material in a highly customized manner
using computer-aided design. The information presented in this article will serve as a useful
reference for the technologies used for a sustainable water treatment strategy in the oil
and gas industry.
Parametric Investigation of Rotary Type Magnetorheological Finishing
Operation by Batch Gradient Descent Algorithm
Authors: Singh Manpreet
Published: September 2024

Background:

The consistency of the magnetorheological process insisted that the
Inconel® 718 material should be furnished. This process involves every material from the categories of soft and hard materials.

Aim:

In this study, a cylindrical ferromagnetic work-part was finished using the
magnetorheological finishing method.

Objective:

The strength of the magnetic flux controls the density and forces in processes that
are assisted by magnetic fields. The mechanism was studied parametrically in this research
work using response surface methodology

Methods:

Optimal process parameters were determined using response surface methodology to
accurately execute the finishing procedure. Each parameter's percentage consumption to the
process's finishing output was also estimated. The finishing of an industrial extrusion punch
was carried out using the optimum parameters obtained from the parametric analysis.

Results:

The RSM optimisation of process parameters is validated using the batch gradient
descent (BGD) algorithm which is the best fit and innovation algorithm for these types of
optimization solutions. The mathematical model that BGD provides confirms the RSM
mathematical model.

Conclusion:

The optimized parameters are useful in controlling the capability of the MR finishing process in various industrial applications.
Exploring the Efficacy and Sustainability of Natural Pesticides in Plant Protection
Authors: Gupta Sheetanshu , Dash Pragyan P. , Mishra Anuradha , Gupta Ramesh Kr.
Published: September 2024

With the increasing demand for sustainable agricultural practices, the efficacy and sustainability
of natural pesticides in plant protection, providing a critical assessment of their potential as
alternatives to synthetic chemical pesticides is the basic demand of the future. This study aimes to
examine the diverse categories of natural pesticides, including plant-based, microbial, and mineralbased
options, and evaluate their effectiveness against a broad range of pests and diseases. We examine
the environmental impact of natural pesticides on non-target organisms, their persistence and
degradation, and the potential for bioaccumulation, focusing on their reduced chemical residues and
ecological compatibility. Typically, natural pesticides target specific areas of the insect, like its nervous
system, leading to the insect's downfall, loss of coordination, paralysis, and eventual death. The
majority of botanical pesticides affect the target organism by poisoning its stomach, lungs, or other
bodily systems. Sincebotanical pesticides are typically fairly biodegradable and may be quickly broken
down by the stomach acids of mammals, their toxicity to humans and animals is typically quite
low, and they are environmentally beneficial. Natural pesticides offer significant environmental,
health, economic, and social benefits, making them an essential component of modern sustainable
agriculture. Their use supports ecological balance, human safety, and long-term agricultural productivity.
Overall, it highlights the promising efficacy and sustainability of natural pesticides, underscoring
their potential for enhancing plant protection while minimizing environmental risks.
Advances in Phytochemical-Based Nanocarrier Approaches for Rheumatoid Arthritis: Challenges and Scope for Future-generation Formulations
Authors: Sandhya Mishra , Pandey Ravindra , Shukla Shiv , Kesharwani Disha
Published: September 2024

The study aims to investigate and assess the effectiveness of current novel techniques
for the preparation of an efficient nanocarrier system in resolving the drawbacks associated with
the delivery of herbal bioactives to treat rheumatoid arthritis. Systematic utilization of various
search engines like Science Direct, Pubmed, Shodhganga, Google Scholar, and Google Patent
databases based on various sets of key phrases has been performed. All the findings from these data
have been studied and briefed based on their relevant and irrelevant information. The current
study summarizes the existing research and development of new nano-formulations with a focus
on herbal bioactive compounds for treating rheumatoid arthritis. Physicochemical properties of
phytoconstituents, such as low aqueous solubility, low permeation coefficient, and chemical instability,
poor bioavailability, short plasma half-life, and ultimately sub-therapeutic efficacy, limit
their clinical translation despite their great potency. The utilization of Phytochemical-Based Nanocarrier
Approaches for rheumatoid arthritis can be a milestone as a major population is affected by
this disease worldwide. The intensive study recapitulates that novel drug delivery systems can provide
new opportunities to efficiently deliver herbal bioactives with improved pharmacokinetic and
pharmacodynamic properties. The exhaustive study concluded that transferosomes, ethosomes,
transethosomes, niosomes, phytosomes, Solid Lipid Nanoparticles (SLN), Nano Lipid Carriers
(NLC), bilosomes and hylurosomes are some of the efficient nanocarrier systems that may impart
numerous benefits to the delivery of herbal bioactives for treatment of RA. These nanocarrier systems
fabricated with phytoconstituents flaunt the evident promising benefits of improved aqueous
solubility, low first-pass metabolism with upgraded bioavailability, sustained release action, resistance
to enzymatic degradation etc. providing support in rheumatoid arthritis recovery. This review
discusses that the upgradation of the pharmacological action and other relevant issues of herbal
bioactives are possible by utilizing novel drug delivery systems, resulting in successful development
of nano-loaded herbal bioactives. It also focuses on highlighting the pioneering progression
in the field of herbal bioactives-loaded nanocarrier systems for rheumatoid arthritis both in
vitro and in vivo along with their advanced preparation methods and applications and discussing
the opportunities for further prospects. This compiled informative review will enlighten various researchers
in the field of delivering herbal bioactives for rheumatoid arthritis.
Pengaruh Manajemen Modal Kerja Terhadap Profitabilitas Perusahaan
Authors: Nabella Efryca Ayu , Djazuli Atim
Published: September 2024

The importance of working capital management is observable from its role of measuring success and increasing profits. The objective of this research is to identify the effects of working capital management on the profitability of food-and-beverage companies listed on the Indonesia Stock Exchange during the 2018-2022 period. The working capital was measured using inventory conversion period, average collection period, and payables deferral period, while the profitability was measures using return on assets. Using saturated sampling, all 20 companies were included as the sample. The data was analyzed using multiple linear regression in SPSS version 27. This study finds that inventory conversion period, average collection period, and payables deferral period simultaneously have significant effects on the companies’ return on assets. In partial, only does payables deferral period positively and significantly influence the return on assets. This means that the longer the payables deferral period, the higher the profitability because the companies can use the available find to invest in other sectors to increase the chance of attaining a higher profitability. Further, inventory conversion period and average collection period do not significantly influence return on assets. This is an indication that there is no correlation between the duration or the swiftness of inventory conversion period and average collection period and the companies’ profitability.
 
Abstrak
Pentingnya manajemen modal kerja dapat dilihat dari peranannya untuk mengukur keberhasilan dalam meningkatkan laba. Penelitian ini, bertujuan untuk mengetahui pengaruh manajemen modal kerja terhadap profitabilitas perusahaan-perusahaan Makanan dan Minuman yang Terdaftar di Bursa Efek Indonesia tahun 2018-2022. Modal kerja diukur menggunakan periode konversi persediaan, periode penerimaan rata-rata, dan periode penangguhan utang, sedangkan profitabilitas diukur dengan Return on Asset. Pengambilan sampel dilakukan dengan teknik sampel jenuh, sehingga didapatkan sampel berjumlah 20 perusahaan. Data diolah dengan menggunakan metode analisis regresi liner berganda menggunakan SPSS versi 27. Hasil penelitian menunjukkan bahwa periode persediaan, periode penerimaan rata-rata, dan periode penangguhan utang berpengaruh signifikan secara simultan terhadap Return on Asset perusahaan. Secara parsial, hanya periode penangguhan utang yang memiliki pengaruh signifikan positif terhadap Return on Asset. Artinya, semakin lama periode penangguhan utang dapat meningkatkan profitabilitas, karena perusahaan dapat menggunakan dana yang tersedia untuk berinvestasi di sektor lain terlebih dahulu untuk memperbesar peluang dalam mencapai profitabilitas yang lebih tinggi. Periode konversi persediaan dan periode penerimaan rata-rata tidak berpengaruh signifikan terhadap Return on Asset. Hal ini berarti tidak ada korelasi antara durasi atau kecepatan periode konversi persediaan dan penerimaan rata-rata dengan tingkat profitabilitas perusahaan.