bluuebunny/crossref_metadata_2025 huggingface dataset:
A POLE Splice Site Deletion Detected in a Patient with Biclonal CLL and Prostate Cancer: A Case Report
Authors: Steiner Markus , Gassner Franz J. , Parigger Thomas , Neureiter Daniel , Egle Alexander , Geisberger Roland , Greil Richard , Zaborsky Nadja
Published: August 2021

Chronic lymphocytic leukemia (CLL) is considered a clonal B cell malignancy. Sporadically, CLL cases with multiple productive heavy and light-chain rearrangements were detected, thus leading to a bi- or oligoclonal CLL disease with leukemic cells originating either from different B cells or otherwise descending from secondary immunoglobulin rearrangement events. This suggests a potential role of clonal hematopoiesis or germline predisposition in these cases. During the screening of 75 CLL cases for kappa and lambda light-chain rearrangements, we could detect a single case with CLL cells expressing two distinct kappa and lambda light chains paired with two separate immunoglobulin heavy-chain variable regions. Furthermore, this patient also developed a prostate carcinoma. Targeted genome sequencing of highly purified light-chain specific CLL clones from this patient and from the prostate carcinoma revealed the presence of a rare germline polymorphism in the POLE gene. Hence, our data suggest that the detected SNP may predispose for cancer, particularly for CLL.
Construction and Performance Monitoring of Innovative Ultra-High-Performance Concrete Bridge
Authors: Kim Haena , Moon Byungkyu , Hu Xinyu , Lee Hosin (David) , Ryu Gum-Sung , Koh Kyung-Taek , Joh Changbin , Kim Byung-Suk , Keierleber Brian
Published: August 2021

The application of Ultra-High-Performance Concrete (UHPC) materials in rehabilitating bridges and constructing primary bridge components is increasing rapidly across the world because of their superior strength and durability characteristics when compared to regular concretes. However, there have been few new bridges constructed using UHPC materials with regular formworks, ready-mix trucks, and construction equipment. This paper presents a comprehensive report encompassing the design, construction, and performance monitoring of a new bridge constructed in Iowa using a unique UHPC technology that includes steel fibers of two different lengths embedded in the concrete. By using optimized lengths of steel fibers, both the tensile strength and the toughness were increased. The UHPC material was produced with local cement and aggregates in the US using typical ready-mix concrete equipment. This paper discusses the experience gained from the design and construction process including mix design, batching, delivery of steel fibers to the ready-mix concrete batch unit, and post-tensioning of precast slabs at the jobsite. For four years after construction, the joints of the bridge decks were monitored using strain sensors mounted on both sides of the deck joints. The strain values were quite similar between the two sides of each joint, indicating a good load transfer between precast bridge girders. A bridge was successfully constructed using a unique UHPC technology incorporating two different lengths of steel fibers and utilizing local cement and aggregates and a ready-mix truck, and has been performing satisfactorily with a good load transfer across post-tensioned precast girder joints.
Incidence of COVID-19 Hospitalisation in Patients with Systemic Lupus Erythematosus: A Nationwide Cohort Study from Denmark
Authors: Cordtz René , Kristensen Salome , Dalgaard Louise Plank Holm , Westermann Rasmus , Duch Kirsten , Lindhardsen Jesper , Torp-Pedersen Christian , Dreyer Lene
Published: August 2021

Background: Patients with systemic lupus erythematosus (SLE) have an increased risk of infections due to impaired immune functions, disease activity, and treatment. This study investigated the impact of having SLE on the incidence of hospitalisation with COVID-19 infection. Methods: This was a nationwide cohort study from Denmark between 1 March 2020 to 2 February 2021, based on the linkage of several nationwide registers. The adjusted incidence of COVID-19 hospitalisation was estimated for patients with SLE compared with the general population in Cox-regression models. Among SLE patients, the hazard ratio (HR) for hospitalisation was analysed as nested case-control study. Results: Sixteen of the 2533 SLE patients were hospitalised with COVID-19 infection. The age-sex adjusted rate per 1000 person years was 6.16 (95% CI 3.76–10.08) in SLE patients, and the corresponding hazard ratio was 2.54 (95% CI 1.55–4.16) compared with the matched general population group after adjustment for comorbidities. Among SLE patients, hydroxychloroquine treatment was associated with a HR for hospitalisation of 0.61 (95% CI 0.19–1.88), and 1.06 (95% CI 0.3–3.72) for glucocorticoid treatment. Conclusion: Patients with SLE were at increased risk of hospitalisation with COVID-19.
The Role of Cytokines in the Pathogenesis of Schizophrenia
Authors: Dawidowski Bartosz , Górniak Adrianna , Podwalski Piotr , Lebiecka Zofia , Misiak Błażej , Samochowiec Jerzy
Published: August 2021

Schizophrenia is a chronic mental illness of unknown etiology. A growing and compelling body of evidence implicates immunologic dysfunction as the key element in its pathomechanism. Cytokines, whose altered levels have been increasingly reported in various patient populations, are the major mediators involved in the coordination of the immune system. The available literature reports both elevated levels of proinflammatory as well as reduced levels of anti-inflammatory cytokines, and their effects on clinical status and neuroimaging changes. There is evidence of at least a partial genetic basis for the association between cytokine alterations and schizophrenia. Two other factors implicated in its development include early childhood trauma and disturbances in the gut microbiome. Moreover, its various subtypes, characterized by individual symptom severity and course, such as deficit schizophrenia, seem to differ in terms of changes in peripheral cytokine levels. While the use of a systematic review methodology could be difficult due to the breadth and diversity of the issues covered in this review, the applied narrative approach allows for a more holistic presentation. The aim of this narrative review was to present up-to-date evidence on cytokine dysregulation in schizophrenia, its effect on the psychopathological presentation, and links with antipsychotic medication. We also attempted to summarize its postulated underpinnings, including early childhood trauma and gut microbiome disturbances, and propose trait and state markers of schizophrenia.
Left Ventricular Apex: A “Minimally Invasive Motorway” for Safe Cardiovascular Procedures
Authors: Agostinelli Andrea , Gallingani Alan , Maestri Francesco , Grossi Silvia , Gripshi Florida , De Donno Luca , Nicolini Francesco
Published: August 2021

Since the advent of TAVR (transcatheter aortic valve replacement), the transapical surgical approach has been affirmed as a safe and effective alternative access for patients with unsuitable peripheral arteries. With the improvement of devices for transfemoral approach and the development of other alternative accesses, the number of transapical procedures has decreased significantly worldwide. The left ventricular apex, however, has proved to be a safe and valid alternative access for various other structural heart procedures such as mitral valve repair, mitral valve-in-valve or valve-in-ring replacement, transcatheter mitral valve replacement (TMVR), transcatheter mitral paravalvular leak repair, and thoracic aorta endovascular repair (TEVAR). We review the literature and our experience of various hybrid transcatheter structural heart procedures using the transapical surgical approach and discuss pros and cons.
How to Measure Intraocular Pressure: An Updated Review of Various Tonometers
Authors: Brusini Paolo , Salvetat Maria Letizia , Zeppieri Marco
Published: August 2021

Intraocular pressure (IOP) is an important measurement that needs to be taken during ophthalmic examinations, especially in ocular hypertension subjects, glaucoma patients and in patients with risk factors for developing glaucoma. The gold standard technique in measuring IOP is still Goldmann applanation tonometry (GAT); however, this procedure requires local anesthetics, can be difficult in patients with scarce compliance, surgical patients and children, and is influenced by several corneal parameters. Numerous tonometers have been proposed in the past to address the problems related to GAT. The authors review the various devices currently in use for the measurement of intraocular pressure (IOP), highlighting the main advantages and limits of the various tools. The continuous monitoring of IOP, which is still under evaluation, will be an important step for a more complete and reliable management of patients affected by glaucoma.
Effect of Compression Stockings after Endovenous Laser Ablation of the Great Saphenous Vein with a 1470 nm Diode Laser Device and a 2ring Fiber
Authors: Fischer Laura , Maurins Uldis , Rabe Eberhard , Rits Juris , Kadiss Arnolds , Prave Sandra , Vigants Rets , Pannier Felizitas
Published: August 2021

The aim of this study was to demonstrate the effects of compression following the endovenous laser ablation (EVLA) of incompetent great saphenous veins (GSVs) using a 1470 nm diode laser (Ceralas E 1470 nm, biolitec) and a 2ring radial fiber (ELVeS Radial 2ring™, biolitec). In this single-center prospective study, 150 legs of 150 consecutive patients were randomly allocated to one of three groups (A, B, and C). Group A patients did not undergo postoperative compression. Group B patients wore a thigh-length graduated compression stocking (23–32 mmHg) for 7 days, whereas group C patients wore the same stocking for 28 days. No additional phlebectomies or sclerotherapies were performed. Investigations were performed prior to intervention, at the day of intervention (D0), at day 7 (D7), and at day 28 post intervention (D28). The primary endpoint was post-interventional pain measured on a 10-point scale. A significant but small pain decrease was observed in the first week of compression, by comparing group B’s mean pain scores to those of group A (p = 0.009). Wearing a compression stocking after EVLA reduced pain within the first week on a significant, but low level. Taking the very low differences in pain levels into account, the difference may not be clinically relevant and post-treatment compression may not be necessary if no additional phlebectomies or sclerotherapies are performed.
Clinical and Surgical Outcomes in Extensive Scalp Reconstruction after Oncologic Resection: A Comparison of Anterolateral Thigh, Latissimus Dorsi and Omental Free Flaps
Authors: del Castillo Pardo de Vera José Luis , Navarro Cuéllar Carlos , Navarro Cuéllar Ignacio , Cebrián Carretero José Luis , Bacián Martínez Sandra , García-Hidalgo Alonso María Isabel , Sánchez-Pérez Arturo , Zamorano-León Jose J. , López-Farré Antonio J. , Navarro Vila Carlos
Published: August 2021

Microsurgical scalp reconstruction is indicated in patients with large scalp defects. The aim of this study was to compare the outcomes of scalp reconstruction in oncologic patients reconstructed with latissimus dorsi (LD), anterolateral thigh (ALT), and omental (OM) free flaps. Thirty oncologic patients underwent scalp reconstruction with LD (10), ALT (11), and OM (9) flaps. The length of the vascular pedicle, the operation time, the possibility of a two-team approach, the length of hospital stays, the complications, and the aesthetic results were evaluated. The OM flap was the flap with the shortest vascular pedicle length with a mean of 6.26 ± 0.16 cm, compared to the LD flap, which was 12.34 ± 0.55 cm and the ALT flap with 13.20 ± 0.26 cm (p < 0.05). The average time of surgery was 6.6 ± 0.14 h in patients reconstructed with OM, compared to the LD flap, which was 8.91 ± 0.32 h and the ALT flap with 7.53 ± 0.22 h (p < 0.05). A two-team approach was performed in all patients for OM flaps and ALT flaps, but only in two patients reconstructed with the LD flap (p < 0.001). In patients reconstructed with the OM flap, a very satisfactory or satisfactory result was reported in seven patients (77.8%). Eight patients reported a very unsatisfactory or unsatisfactory result with LD flap (80%) and 10 patients with ALT flap (90.9%) (p = 0.002). The mean hospital stay after surgery was not statistically significant (p > 0.05). As for complications, two patients reconstructed with OM flap, five LT flaps, and two ALT flaps developed complications, not statistically significant (p = 0.235). Omental flap, latissimus dorsi flap, and anterolateral thigh flap fulfill most of the characteristics for complex scalp reconstruction. The decision on which flap to use should be based on clinical aspects of the patients taking into account that the three flaps show similar rates of complications and length of hospital stay. Regarding the aesthetic outcome, OM flap or LD flap should be considered for reconstruction of extensive scalp defects.
Multiparametric MRI Evaluation of Oropharyngeal Squamous Cell Carcinoma. A Mono-Institutional Study
Authors: Piludu Francesca , Marzi Simona , Gangemi Emma , Farneti Alessia , Marucci Laura , Venuti Aldo , Benevolo Maria , Pichi Barbara , Pellini Raul , Sperati Francesca , Covello Renato , Sanguineti Giuseppe , Vidiri Antonello
Published: August 2021

The aim of this paper is to define the pre-treatment radiological characteristics of oropharyngeal squamous cell carcinoma (OPSCC) using morphological and non-morphological magnetic resonance imaging (MRI), based on HPV status, in a single-institution cohort. In total, 100 patients affected by OPSCC were prospectively enrolled in the present study. All patients underwent 1.5T MR with standard sequences, including diffusion-weighted imaging with and intravoxel incoherent motion (IVIM-DWI) technique and a dynamic contrast-enhanced (DCE) MRI. For all patients, human papillomavirus (HPV) status was available. No statistically significant differences in the volume of primary tumors (PTs) and lymph nodes (LNs) were observed based on HPV status. When comparing the two patient groups, no significant differences were found for the PT radiologic characteristics (presence of well-defined borders, exophytic growth, ulceration, and necrosis) and LN morphology (solid/cystic/necrotic). Tumor subsite, smoking status, and alcohol intake significantly differed based on HPV status, as well as ADC and Dt values of both PTs and LNs. We detected no significant difference in DCE-MRI parameters by HPV status. Based on a multivariate logistic regression model, the combination of clinical factors, such as tumor subsite and alcohol habits, with the perfusion-free diffusion coefficient Dt of LNs, may help to accurately discriminate OPSCC by HPV status.
Diagnostic Performance of Procalcitonin for the Early Identification of Sepsis in Patients with Elevated qSOFA Score at Emergency Admission
Authors: Bolanaki Myrto , Möckel Martin , Winning Johannes , Bauer Michael , Reinhart Konrad , Stacke Angelika , Hajdu Peter , Slagman Anna
Published: August 2021

Infectious biomarkers such as procalcitonin (PCT) can help overcome the lack of sensitivity of the quick Sequential Organ Failure Assessment (qSOFA) score for early identification of sepsis in emergency departments (EDs) and thus might be beneficial as point-of-care biomarkers in EDs. Our primary aim was to investigate the diagnostic performance of PCT for the early identification of septic patients and patients likely to develop sepsis within 96 h of admission to an ED among a prospectively selected patient population with elevated qSOFA score. In a large multi-centre prospective cohort study, we included all adult patients (n = 742) with a qSOFA score of at least 1 who presented to the ED. PCT levels were measured upon admission. Of the study population 27.3% (n = 202) were diagnosed with sepsis within the first 96 h. The area under the curve for PCT for the identification of septic patients in EDs was 0.86 (95% confidence interval (CI): 0.83–0.89). The resultant sensitivity for PCT at a cut-off of 0.5 µg/L was 63.4% (95% CI: 56.3–70.0). Furthermore, specificity was 89.2% (95% CI: 86.3–91.7), the positive predictive value was 68.8% (95% CI: 62.9–74.2), and the negative predictive value was 86.7% (95% CI: 84.4–88.7). The early measurement of PCT in a patient population with elevated qSOFA score served as an effective tool for the early identification of sepsis in ED patients.
Post-Intensive Care Syndrome and Its New Challenges in Coronavirus Disease 2019 (COVID-19) Pandemic: A Review of Recent Advances and Perspectives
Authors: Nakanishi Nobuto , Liu Keibun , Kawakami Daisuke , Kawai Yusuke , Morisawa Tomoyuki , Nishida Takeshi , Sumita Hidenori , Unoki Takeshi , Hifumi Toru , Iida Yuki , Katsukawa Hajime , Nakamura Kensuke , Ohshimo Shinichiro , Hatakeyama Junji , Inoue Shigeaki , Nishida Osamu
Published: August 2021

Intensive care unit survivors experience prolonged physical impairments, cognitive impairments, and mental health problems, commonly referred to as post-intensive care syndrome (PICS). Previous studies reported the prevalence, assessment, and prevention of PICS, including the ABCDEF bundle approach. Although the management of PICS has been advanced, the outbreak of coronavirus disease 2019 (COVID-19) posed an additional challenge to PICS. The prevalence of PICS after COVID-19 extensively varied with 28–87% of cases pertaining to physical impairments, 20–57% pertaining to cognitive impairments, and 6–60% pertaining to mental health problems after 1–6 months after discharge. Each component of the ABCDEF bundle is not sufficiently provided from 16% to 52% owing to the highly transmissible nature of the virus. However, new data are emerging about analgesia, sedation, delirium care, nursing care, early mobilization, nutrition, and family support. In this review, we summarize the recent data on PICS and its new challenge in PICS after COVID-19 infection.
Remission of Diabetes Following Bariatric Surgery: Plasma Proteomic Profiles
Authors: Insenser María , Vilarrasa Nuria , Vendrell Joan , Escobar-Morreale Héctor F.
Published: August 2021

Bariatric surgery restores glucose tolerance in many, but not all, severely obese subjects with type 2 diabetes (T2D). We aimed to evaluate the plasma protein profiles associated with the T2D remission after obesity surgery. We recruited seventeen women with severe obesity submitted to bariatric procedures, including six non-diabetic patients and eleven patients with T2D. After surgery, diabetes remitted in 7 of the 11 patients with T2D. Plasma protein profiles at baseline and 6 months after bariatric surgery were analyzed by two-dimensional differential gel electrophoresis (2D-DIGE) and matrix-assisted laser desorption/ionization-time-of-flight/time-of-flight coupled to mass spectrometry (MALDI-TOF/TOF MS). Remission of T2D following bariatric procedures was associated with changes in alpha-1-antichymotrypsin (SERPINA 3, p < 0.05), alpha-2-macroglobulin (A2M, p < 0.005), ceruloplasmin (CP, p < 0.05), fibrinogen beta chain (FBG, p < 0.05), fibrinogen gamma chain (FGG, p < 0.05), gelsolin (GSN, p < 0.05), prothrombin (F2, p < 0.05), and serum amyloid p-component (APCS, p < 0.05). The resolution of diabetes after bariatric surgery is associated with specific changes in the plasma proteomic profiles of proteins involved in acute-phase response, fibrinolysis, platelet degranulation, and blood coagulation, providing a pathophysiological basis for the study of their potential use as biomarkers of the surgical remission of T2D in a larger series of severely obese patients.
MR Imaging Biomarkers for Clinical Impairment and Disease Progression in Patients with Shoulder Adhesive Capsulitis: A Prospective Study
Authors: Gillet Romain , Zhu François , Padoin Pierre , Rauch Aymeric , Hossu Gabriela , Teixeira Pedro Augusto Gondim , Blum Alain
Published: August 2021

Background: MRI diagnostic criteria of shoulder adhesive capsulitis (AC) are nowadays widely used, but there is little information available on the association between MRI findings and clinical impairment. Purpose: To determine the correlation of MRI findings with the Constant–Murley Score (CMS), pain duration and symptoms at the one-year follow-up in AC patients. Materials and methods: This monocentric prospective study included 132 patients with a clinical diagnosis of shoulder AC who underwent shoulder MRI. Mean patient age was 54.1 ± 9.3 years, and there were 55 men and 77 women. A radiologist examined all patients and completed the CMS just prior to MRI. Pain duration was assessed along with the signal intensity and measured the maximal thickness of the inferior glenohumeral ligament (IGHL) by two radiologists. Medical record analysis was performed in a sub-group of 49 patients to assess prognosis approximately one year after the MRI examination. Linear regression analysis with the Pearson test and the Fisher exact test were used to determine the association between MRI findings and clinical impairment. Results: There was a significant difference in mean pain duration score (3.8 ± 1.2 versus 3.2 ± 0.9 and 3.8 ± 1.2 versus 3.2 ± 0.9, respectively, for readers 1 and 2) and in mean mobility scores (15.7 ± 8 points versus 19.6 ± 10.1 points and 15.8 ± 8.2 points versus 19.4 ± 10 points, respectively, for readers 1 and 2) in patients with a high IGHL signal compared to those with a low IGHL signal (p < 0.05). IGHL was thicker in patients with clinical improvement at one-year follow-up compared to those presenting clinical stability or worsening (p < 0.05). Conclusions: In patients with shoulder AC, the degree of signal intensity at the IGHL was inversely related to shoulder pain duration and range of motion, and a thickened IGHL indicated a favorable outcome at one-year follow-up.
A cientificidade nos estudos de comunicação: A virada na reflexão brasileira
Authors: Rüdiger Francisco
Published: August 2021

O artigo resume e analisa a trajetória das discussões da comunidade brasileira de pesquisadores em comunicação acerca do estatuto epistemológico de sua área de conhecimento, das origens, nos anos 1970, até o início do atual século, considerando em detalhe a contribuição de três autores: Eduardo Neiva, Tiago Quiroga e Efendy Maldonado. O estudo aponta a maneira como se passou do consenso sobre a sua interdisciplinaridade, marcante na primeira etapa, para a reivindicação de sua autonomia científica, característica do período mais recente, via o emprego dos conceitos de disciplina e transdiciplinaridade. A pesquisa é documental e a estratégia metodológica da análise recorre à reconstrução racional da argumentação encontrada nos materiais que permitiram à autoria mapear as transições epistemológicas acima indicadas. Adotando como como ponto de partida a análise do trabalho de Neiva, o texto segue detalhando as teses e os problemas das empresas de Quiroga e Maldonado. A condução do raciocínio apresenta argumentos semeadores de dúvida e, evitando externar tese própria, defende, em conclusão, que se veja com ceticismo as postulações feitas ao longo deste movimento em conjunto, a despeito delas terem esboçado escola após 2000.
Reunião conceitual no filme A separação: Desafios e astúcias das dialéticas da tragédia
Authors: Chataignier Gustavo , Baez Luiz
Published: August 2021

Partindo da filosofia de G. W. F. Hegel, nomeadamente de sua ideia sobre a modernidade enquanto tempo de separações, bem como de seus escritos acerca da arte e da tragédia — sobretudo no que concerne à figura de Antígona —, este artigo investiga as operações cinematográficas empreendidas pelo diretor persa Asghar Farhadi no filme A separação (2011), vencedor do Oscar e de três prêmios no Festival de Berlim. Entende-se, para tanto, a obra não em continuidade com um cinema metarrealista e autorreflexivo característico do Irã nos anos 1990, mas antes em ruptura, como um retorno contemporâneo ao trágico. Esse regresso, em vez de simplesmente obedecer aos esquemas narrativos herdados da Grécia, insere-se no terreno de uma arte construída por distâncias e intervalos inaugurados por enquadramento e montagem. Nessa lógica, para além de seu referente imediato, um conflito judicial entre marido e esposa, a “separação” do título se universaliza, dizendo também respeito a processos entre indivíduo e Estado, vida e morte, diferenças de gênero e de classe ou, em última instância, à dialética fundadora do audiovisual, entre o audível e o visível.
Transe de possessão e línguas em interações rituais: Goffman e a Ciência Cognitiva da Religião
Authors: Pilar Araújo Paulo Jeferson
Published: August 2021

Neste ensaio, proponho uma relação possível entre a área conhecida como ciência cognitiva da religião e o fenômeno das línguas religiosas ou línguas rituais. Os construtos de Goffman desenhados para abarcar as interações sociais face a face são utilizados como categorias analíticas, principalmente as de “fachada” e footing. O ponto de relação entre as ciências cognitivas da religião e as línguas rituais é o fenômeno religioso do transe de possessão e o uso de línguas nas interações rituais envolvendo esse fenômeno. Busco demonstrar os direcionamentos possíveis de investigação se as línguas rituais passem a ser analisadas sob uma ótica goffmaniana. Espero, com isso, contribuir com um novo olhar sobre um aspecto de interações sociais ainda pouco examinado nos estudos linguísticos no Brasil, o da relação entre linguagem e religião.PALAVRAS-CHAVE:
Spinale Muskelatrophie - ein Update
Authors: Perdikari Aliki , Klein Andrea , Jacquier David
Published: August 2021

Die spinale Muskelatrophie (SMA: Unter dieser Bezeichnung werden wir nur auf die «5q-assoziierte spinale Muskelatrophie» eingehen) ist eine progrediente neuromuskuläre Krankheit, welche die unteren Motoneurone befällt und zu einer zunehmenden Muskelschwäche führt. Lange Zeit eine der hauptsächlichsten genetischen Ursachen der Kindessterblichkeit, haben die wissenschaftlichen Fortschritte der letzten zwei Jahrzehnte die ersten spezifischen Behandlungen ermöglicht und zu einer Revolution in der Betreuung dieser Patienten geführt. Wir werden hier die Krankheit, die pathogenetischen Mechanismen, das klinische Bild und die derzeit verfügbaren therapeutischen Möglichkeiten besprechen.
Nouvelles thérapies d’épilepsies de l’enfant
Authors: Kröll Judith , Datta Alexandre N
Published: August 2021

Malgré le développement de nouveaux médicaments au cours de ces dernières décennies, le nombre de patients avec une épilepsie pharmaco-résistante n’a guère changé. La compréhension croissante de l’étiologie des épilepsies, y compris les causes génétiques et structurelles, permet d’identifier chez certains patients des cibles moléculaires spécifiques et de proposer des traitements qui dépassent la suppression des crises en traitant la cause de l’épilepsie. Le grand défi reste toujours et encore l’identification précoce des causes afin de garantir au patient le meilleur choix thérapeutique.
TWO CUTTING TURNING OF BODIES OF REVOLUTION
Authors: Drachev O. I. , Kravtsov A. N.
Published: August 2021

The technology of two-cut rough and rough turning of rotation bodies in relation to lathes is considered. Dynamics of part working surfaces formation by longitudinal oscillations of cutters with phase delay of finishing cutter from rough one is shown. Dynamics of finishing cutter in function of damping coefficient is considered. The mathematical model of two-cut turning process is given.
ORGANIZATION OF THE QMS AS A DIRECTION FOR IMPROVING THE COMPETITIVENESS OF THE ENTERPRISE
Authors: Kargina Zh. A. , Krainev D. V.
Published: August 2021

The article provides a theoretical description of the QMS, recommendations for improvement, describes the concepts of quality, management approaches, structure, requirements and problems encountered in improving it.
DETERMINING THE OPTIMAL BACK ANGLE OF A BATCH SAW USING THERMAL FIELD MODELING
Authors: Makarova O. A. , Zhdanov A. A. , Arzhukhanov R. I. , Siukova E. O.
Published: August 2021

This publication deals with the issue related to the study of the heat distribution in the tooth of a saw with a modified geometry, taking into account the frequency of the process of cutting cold rolled metal with circular saws.
METHODS FOR ESTIMATING THERMFISICAL PROPERTIES OF THE "TOOL - STEEL WORKPIECE" CONTACT PAIR AND THE POSSIBILITY OF THEIR USE IN CALCULATION OF THE PARAMETERS OF THE TURNING PROCESS
Authors: Plotnikov A. L. , Tikhonova Zh. S. , Zhdanov A. A.
Published: August 2021

The analysis of methods for assessing the properties of contact pairs "hard alloy tool - steel workpiece" with the aim of improving the reliability of the choice of turning modes in generations of CNC systems equipped with technical intelligence. The models for calculating the cutting speed, the cutting force, the value of roughness Ra, have been corrected by introducing into their structure an additional informative value about the properties of each contact pair - the thermoEMF of the trial cut.
MODERNIZATION OF CONTROL UNIT OF ROLLERS FOR TRANSPORTATION OF PIPE BILLETS
Authors: Gorbunov M. G. , Barabanov V. G.
Published: August 2021

A control system for the electric drive of roller tables has been developed. Basic electrical and connection diagrams have been developed. The characteristics of all devices included in the system are given. The main advantages of using frequency regulation are described. The algorithm of the control program is described in detail.
PECULIARITIES OF THE PROCESS OF ULTRASONIC VIBRATION MASHINING
Authors: Agapov S. I. , Prokhvatilov A. S. , Tolstyakov A. F. , Zayarny D. V.
Published: August 2021

The paper discusses the distinctive features of the machining process during low-module gear cutting with ultrasonic vibration of the blank.
DEVELOPMENT OF CONTROL PROGRAM AND HMI-INTERFACE FOR A SYSTEM OF PREVENTION OF EMERGENCY SITUATIONS IN A SLIDING SUPPORT OF A GAS PUMPING UNIT
Authors: Kukhtik M. P. , Repnikov A. I. , Serdobintsev Yu. P. , Khaustov M. A.
Published: August 2021

Control program for automated system of prevention of emergency situations in a sliding support of a gas pumping unit has been written. HMI-interface of operator control panel has been developed.
Marisa Rey-Henningsen y el arte de la traducción de la literatura danesa
Authors: Garrosa Gude José Luis
Published: August 2021

De entre las múltiples actividades de creación y de investigación de Marisa Rey-Henningsen (Madrid, 1936), destacamos sus traducciones de algunas importantes obras de la literatura danesa, hasta entonces inéditas en español. Gracias a su trabajo, el lector de lengua española ha podido acceder, entre otros, a textos de autores tan relevantes como En landsbydegns dagbog (Diario de un sacristán de pueblo), de Steen Steensen Blicher o I Spanien (Viaje por España), de Hans Christian Andersen. En este trabajo se aborda su labor como traductora y se hace hincapié tanto en su carácter pionero como en su importancia para el conocimiento de las culturas  nórdicas.
El danés peligroso. Semblante humano de Gustav Henningsen. Evocación a cuatro manos
Authors: Dedieu Jean-Pierre , Knutsen Gunnar
Published: August 2021

Gustav Henningsen, aparte de ser un gran investigador, es también una personalidad fuera de lo común. Raras veces su entusiasmo pasa desapercibido. Tuvo pocos alumnos. Pero a estos los marcó de una impronta  indeleble. Dos de ellos dan testimonio.
“Un danés peligroso” en los fondos del Archivo Histórico Nacional
Authors: Contreras Contreras Jaime
Published: August 2021

El autor aborda la evolución intelectual de Gustav Henningsen y cómo acabó por centrarse en uno de los grandes proyectos de investigación documental: las relaciones de causas de fe. Analiza el interés de esta documentación para un estudio cuantitativo del número de procesados por la Inquisición y sus diversas posibilidades para los estudios históricos.
Gustav Henningsen: del antropólogo al historiador (pasando por archivero)
Authors: Pulido Serrano Juan Ignacio
Published: August 2021

En este trabajo se expone la evolución experimentada por la investigación de Gustav Henningsen en los campos de la antropología, de la historia y de la archivística. Se presenta también el sentido de su obra, con las principales aportaciones que ha realizado a la historia social y cultural de Europa en la Edad Moderna, en temáticas como son las prácticas y creencias mágicas de las sociedades del pasado. Entre sus aportacionesse señalan sus descubrimientos y estudios de fondos procedentes de los archivos de la Inquisición española, los métodos de trabajo novedosos que aplicó sobre ellos y la creación de herramientas para el análisis que han sido utilizadas posteriormente.
Los niños como víctimas y los niños como verdugos en la caza de brujas: Navarra, siglo XVI
Authors: Usunáriz Jesús M.
Published: August 2021

Este trabajo tiene como objetivo analizar el papel jugado por los niños en los procesos judiciales contra las brujas de la Navarra del siglo XVI, en el contexto de la Europa occidental. Estos aparecieron tradicionalmente como víctimas propiciatorias e inocentes de una secta; pero también tuvieron, como denunciantes y testigos, una importante responsabilidad en la persecución de parientes y vecinos, en lo que sería un precedente de su gran protagonismo en la caza de brujas de los inicios del siglo XVII. El texto también intenta explicar por qué se acusó a las brujas de asesinar a niños o cómo y por qué los niños describieron, con todo detalle, las reuniones y los maleficios de las brujas.
Volver a las relaciones de causas. El ejemplo de los berberiscos del reino de Granada
Authors: Vincent Bernard
Published: August 2021

Desde los años noventa del siglo pasado, el recurso a las relaciones de causas ha sido abandonado por los investigadores. Se aboga aquí por un retorno a un uso cuantitativo como cualitativo de estas fuentes. Se toma el ejemplo del examen de la comunidad acusada de profesar el islam en el ámbito del Tribunal de la Inquisición de Granada entre 1571 y 1590 (moriscos, renegados, berberiscos) poniendo énfasis sobre estos últimos, casi siempre esclavos o libertos.
Euskarazko literaturak 2020an zer
Authors: Erro Ángel
Published: August 2021

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El alivio y reparo. La forma audiovisual
Authors: Gutiérrez Diez Margarita
Published: August 2021

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Peningkatan Mutu Penggunaan Antibiotik Bijak Melalui Kesesuaian Temuan Hasil Kultur Dengan Kajian Risiko Pasien Menurut Model Regulasi Antimikroba Sistem Prospektif (Raspro)
Authors: Natadidjaja Ronald Irwanto , Adlani Hadianti , Sumarsono Hadi
Published: August 2021

Masalah Mutu: Standar 4 Kajian SNARS 2018 menyatakan bahwa rumah sakit wajib memiliki surveilens kepekaan kuman terhadap antibiotik. Hal ini harus menjadi dasar pertimbangan pembuatan Panduan Penggunaan Antibiotik (PPAB). Di sisi lain, timbulnya kuman Multi Drug Resistance (MDR) juga dipengaruhi oleh berbagai faktor. Pemberian antibiotik empirik, selain berdasar pada pola kuman, juga sebaiknya mempertimbangkan berbagai faktor risiko timbulnya kuman MDR.

Pilihan Solusi: Regulasi Antimikroba Sistem Prospektif (RASPRO) adalah sebuah model tataguna antimikroba yang disintesis dari berbagai kepustakaan dengan mempertimbangkan berbagai faktor yang dapat menyebabkan timbulnya kuman-kuman MDR pada surveilans kepekaan kuman, sehingga dapat mengarahkan klinisi pada peresepan antibiotik bijak.

Implementasi: Kajian risiko yang dibuat dalam RASPRO menentukan bahwa immunocompromised dan/ atau dengan komorbid Diabetes Melitus yang tidak terkontrol atau dengan riwayat konsumsi antibiotik kurang dari 90 hari, dan/ atau riwayat perawatan di rumah sakit lebih dari 48 jam dalam waktu kurang dari 90 hari, dan/ atau riwayat penggunaan instrumen medis kurang dari 90 hari masuk dalam risiko MDR. Pasien-pasien yang tidak termasuk dalam kategori di atas akan masuk ke dalam prediksi infeksi oleh kuman multisensitif.

Evaluasi dan Pembelajaran: Pada surveilans kepekaan kuman dengan data sekunder diambil dari sebuah rumah sakit swasta tipe B di Jakarta antara tahun 2016-2018, dengan rumus sampel tunggal, didapatkan 106 sampel kultur dari 86 pasien. Terdapat kesesuaian pada 54 dari 57 hasil kultur yang diambil dari pasien dengan kajian risiko infeksi kuman multisensitif (94,74%). Kesesuaian antara temuan hasil kultur MDR dengan kajian risiko model RASPRO terdapat pada 44 dari 49 kultur (89,80%), dengan 9 kultur menunjukkan Extended Spectrum Beta-Lactamase (ESBL). Total kesesuaian hasil kultur dengan kajian risiko empirik model RASPRO mencapai 92,45%. Tingginya persentase kesesuaian temuan kultur kuman penyebab infeksi dengan kajian faktor risiko model RASPRO sepertinya dapat menjadi pertimbangan dalam mengarahkan klinisi dalam pemberian antibiotik empirik spektrum sempit dan luas pada praktek klinis sehari-hari di rumah sakit. Dengan praktik seperti ini kualitas penggunaan antibiotik diharapkan dapat meningkat.
ANALISIS PERAMALAN TINGKAT KEMISKINAN DI INDONESIA DENGAN MODEL ARIMA
Authors: Prasetyono Rinaldo Isnawan , Anggraini Dyah
Published: August 2021

Kemiskinan di Indonesia merupakan masalah yang kompleks dan multidimensi, karena tingkat kemiskinan di suatu negara akan mempengaruhi indikator keberhasilan baik dari segi pembangunan maupun perekonomian negara tersebut. Berdasarkan permasalahan tersebut diperlukan sebuah prediksi untuk mengetahui tingkat kemiskinan di Indonesia baik wilayah Perkotaan, Pedesaan maupun secara Nasional. Pada penelitian kali ini, peneliti menggunakan sebuah model dari Box Jenkins yaitu Auto Regresive Moving Average (ARIMA) untuk memprediksi tingkat kemiskinan di Indonesia pada masa yang akan datang. Dataset kemiskinan yang digunakan bersumber dari Badan Pusat Statistik (BPS) dengan data pengujian dari tahun 2011 hingga tahun 2020. Peneliti akan menggunakan 3 parameter error untuk mengevaluasi hasil tingkat kemiskinan di Perkotaan, Pedesaan maupun secara Nasional yaitu RMSE, MAE dan MAPE. Berdasarkan pengujian yang dilakukan bahwa dataset perkotaan menghasilkan model ARIMA(2,2,5) sebagai model ARIMA terbaik dengan RMSE=1.246582, MAE=0.923255 dan MAPE=12%, untuk dataset pedesaan menghasilkan model ARIMA(1,2,1) sebagai yang terbaik dengan RMSE=0.392650, MAE=0.311529 dan MAPE=2%. Sedangkan untuk dataset secara nasional menghasilkan model ARIMA(0,2,5) sebagai yang terbaik dengan RMSE=2.533166, MAE=2.090505 dan MAPE=20%. Dari 3 pengujian tersebut disimpulkan bahwa model ARIMA berhasil memprediksi tingkat kemiskinan di Indonesia baik wilayah Perkotaan, Pedesaan maupun secara Nasional dengan hasil baik.
Analisis Radiografi Sinar-X Terhadap Sambungan Pelat Baja Tahan Karat Aisi 304 Hasil Pengelasan Tungsten Inert Gas Dengan Arus 40–60 Ampere
Authors: Zayadi Ahmad , Sungkono  , Cahyono HP
Published: August 2021

X-Ray Radiographic Analysis of Aisi 304 Stainless Steel Plate Joints From Inert Gas Tungsten Welding Results with 40 – 60 Ampere Current. Metal welding process is one of the main processes in machine construction. The quality of welded joints determines the strength and toughness of a machine construction. The quality of welded joints of installed construction can be determined by the non-destructive test method using X-ray radiography equipment. This study aims to obtain a butt joint obtained from TIG welding of AISI 304 stainless steel plate with a current of 40 - 60 A, identification of defects in the 1G butt joint, and analysis of the quality of the weld joint. The research method used is testing of welded joints using X-ray radiography which refers to the ASME V article II standard and the connection quality refers to ASME section IX. The results showed that TIG welding with a current of 60 Ampere produced a butt joint butt joint that was penetrated and there was no gap between the plates, whereas with a current of 40 A and 50 A the weld joint was not see-through but there was still a gap between the plates. Incomplete penetration weld defects were found in the welded SS 304 plate joints with a current of 40 A. Welded porosity defects were found in the welded SS 304 plate joints with a current of 50 A. Weld defects were not found in the SS 304 plate joints with a current of 60 A. Butt joint connections TIG welded SS 304 plate with the best current of 60 A compared to the current of 40 A and 50 A.
Price, Volatility and the Second-Order Economic Theory
Authors: Olkhov Victor
Published: August 2021

We introduce the new price probability measure, which entirely depends on the probability measures of the value and the volume of the market trades. We define the nth statistical moment of the price as the ratio of the nth statistical moment of the value to the nth statistical moment of the volume of all trades performed during an averaging time interval Δ. The set of the price statistical moments determines the price characteristic function and its Fourier transform defines the price probability measure. The price volatility depends on the 1st and the 2nd statistical moments of the value and the volume of the trades. The prediction of the price volatility requires a description of the sums of squares of the value and the volume of the market trades during the interval Δ and we call it the second-order economic theory. To develop that theory, we introduce numerical continuous risk ratings and distribute the agents by the risk ratings as coordinates. Based on distributions of the agents by the risk coordinates, we introduce a continuous economic media approximation that describes the collective trades. The agents perform the trades under the action of their expectations. We model the mutual impact of the expectations and the trades and derive equations that describe their evolution. To illustrate the benefits of our approach, in a linear approximation we describe perturbations of the mean price, the mean square price and the price volatility as functions of the first and the second-degree trades’ disturbances.
Stylistics Analysis In Literature of Figurative Language Used In Black Lives Matter Community’s Poems
Authors: Efendi Dedi
Published: August 2021

This research analyzed about figurative language and social values in three poems of Black Live Matter (BLM) community’s poem in America. The purposes of this research are to describe the kinds of figurative language and social values in three poems of BLM community’s poem. In this research, the writer used the descriptive qualitative method and used theory of figurative language by Perrine (1992) and theory of social values by Amir in Sukatman (1991). Data are explained by find the meaning and described them based on the kinds of figurative language through four procedure, they are: identifying, classiying, analyzing and making the conclusion from the data. The result of this research are the writer found about 19 data of figurative language of the poems. Hyperbole is the dominant kind of figurative language in those three poems ,because hyperbole is the appropriate of figurative language for BLM’s proponents for looking for help.  Beside, social values also found in these poems, the most dominant social value in these poems is social value of humanity. Humanity is one of the biggest issue for black people in United State of America.
The Use of Short Stories as Materials for Basic Reading Classes for English Language Education Study Program at Universitas Ekasakti
Authors: Franchisca Sherly
Published: August 2021

Basic reading is conducted to the first semester of English Language Education Study Program at Universitas Ekasakti Padang. There are several text which could be used to in teaching and  learning process. One of them are short stories as the proper one for first semester students. By using short stories, the students could enhance their vocabularies and their undertanding in reading text. Besides, there is also moral value that they could get from the text. Throught those, classroom action research about the use of short stories for Basic Reading class were done for the students which the data were taken from tests, observations, interviews and documentation. Sample of the research were consist of 2 (two) classes of the students. as the result, mean score indicate there is an enhancement during the teaching and learning by using short stories. Using short stories in basic reading class is a very good way and also exciting.
Affinely Adjustable Robust Volt/VAr Control without Centralized Computations
Authors: Nazir Firdous Ul , Pal Bikash , Jabr Rabih
Published: August 2021

This paper proposes a completely non-centralized Volt/VAr control (VVC) algorithm for active distribution networks which are faced with voltage magnitude violations due to the high penetration of solar photovoltaics (PVs). The proposed VVC algorithm employs a two-stage architecture where the settings of the classical voltage control devices (VCDs) are decided in the first stage through a distributed optimization engine powered by the alternating direction method of multipliers (ADMM). In contrast, the PV smart inverters are instructed in the second stage through linear Q(P) decision rules - which are computed in a decentralized manner by leveraging robust optimization theory. The key to this non-centralized VVC routine is a proposed network partition methodology (NPM) which uses an electrical distance metric based on node Q􀀀jV j2 sensitivitiesfor computing an intermediate reduced graph of the network, which is subsequently divided into the final partitions using the spectral clustering technique. As a result, the final network partitions are connected, stable, close in cardinality, contain at least one PV inverter for zonal reactive power support, and are sufficiently decoupled from each other. Numerical results on the UKGDS-95 bus system show that the non-centralized solutions match closely with the centralized robust VVC schemes, thereby significantly reducing the voltage violations compared to the traditional deterministic VVC routines.
Upaya Peningkatan Kualitas Kesehatan Dasar Lansia di Dinas Sosial Lanjut Usia Siborong-Borong
Authors: Sianturi Elly , Rismawati Dimpu , Ujung Riance
Published: August 2021

Penduduk lansia merupakan kelompok usia yang rentan mengalami gangguan kesehatan dengan mortalitas dan morbiditas yang tinggi. keterlibatan wanita bekerja di sektor formal yang menghambat wanita mengurus lansia, sumber-sumber ekonomi yang berkurang dan hilangnya kemampuan merawat diri dalam kehidupan sehari-hari karena penyakit degeneratif dan infeksi mendorong masyarakat modern memasukkan anggota keluarga yang lansia ke panti jompo. Pengabdian masyarakat ini bertujuan untuk meningkatkan pengetahuan warga lansia tentang penyakit degeneratif, upaya pencegahan, deteksi dini penyakit degeneratif melalui pemeriksaan laboratorium sederhana dan pemberian nutrisi tambahan. Metode pengabdian masyarakat dilaksanakan dengan memberikan penyuluhan kesehatan yang diberikan mampu meningkatkan pengetahuan tentang tanda dan gejala, upaya pencegahan serta peningkatan kualitas hidup dimasa lansia. Berdasarkan anmnesa ditemukan sebanyak 17 orang (53,13%) mengalami penyakit degeneratif,  berdasarkan hasil pemeriksan laboratorium sederhana ditemukan 9 orang (28,12%) dengan nilai di atas normal. Setelah pelaksanaan pengabdian masyarakat ini diharapkan warga lansia mampu meningkatkan kualitas hidup dengan menjaga kesehatan melalui upaya pencegahan dan pemeliharaan kesehatan.