bluuebunny/crossref_metadata_2025 huggingface dataset:
Flood Peak Equations Based on Partial Duration Series (PDS) Approach of Rainfall Data Selection in Lack-Data Agricultural Catchment
Authors: Tunas I. Gede , Arafat Yassir , Herman Rudi
Published: March 2022

The present work aims to develop a flood peak equation because of data limitations due to the impact of damage to the streamflow measuring instrument as a result of the 2015 floods at an agricultural catchment in Sulawesi, Indonesia. Hydrologic data for the period 2002-2014 obtained from two hydrologic stations and one hydrometric station were applied to establish the research variables. Three variables were determined using the frequency analysis approach: design rainfall generated from partial duration series (RDP) and annual maximum series (RDA) of daily rainfall data, and design streamflow predicted from annual maximum series of daily streamflow data (QDA). Four types of frequency distributions are tested to determine those variables, consisting of Normal, Log Normal, Log Pearson Type III and Gumbel distributions. The third distribution was selected for determining all the variables with the largest difference in c2 and D values based on Chi-squared and Kolmogorov–Smirnov tests respectively. The design streamflow equation that represents the peak of the flood was formulated by substituting the QDA with an equation generated from the regression analysis of those three variables. A streamflow peak equation was successfully developed as a function of RDP in the form of a power equation with excellent performance measured using Mean Absolute Error (MAE) and Correlation Coefficient (r). This equation could be applied in all of the catchments by accommodating the area's weighting factor of the sub-catchments.
Similarities and Differences of International Practices and Procedures for the Regulation for Active Substance Master Files/Drug Master Files of Human Use: Moving Toward Regulatory Convergence
Authors: Matsuhama Maki , Takishita Tomoko , Kuribayashi Ryosuke , Takagi Kazunori , Wakao Rika , Mikami Kenichi
Published: March 2022

Purpose. A gap analysis survey of international practices for Active Substance Master Files (ASMFs)/Drug Master Files (DMFs) of human use was conducted as a project of the ASMF/DMF working group of the International Generic Drug Regulators Pilot (IGDRP) to identify similarities and differences among ASMF/DMF procedures of 10 IGDRP members and 2 observers. Methods. We conducted a questionnaire survey and compared the following aspects: overall ASMF/DMF procedures, submission requirements for ASMFs/DMFs, assessment processes for ASMFs/DMFs, the technical requirements for active pharmaceutical ingredients (APIs), generation of assessment reports for ASMFs/DMFs, procedures for changing ASMF/DMF details, and Good Manufacturing Practice (GMP) inspection/certification of API manufacturers. Twelve organizations participated in this project: the Brazilian Health Surveillance Agency (Anvisa), the European Union (EU), Health Canada (HC), the Singapore Health Sciences Authority (HSA), the South African Medicines Control Council (MCC), the South Korean Ministry of Food and Drug Safety (MFDS), the Japanese Pharmaceuticals and Medical Devices Agency (PMDA), the Swiss Agency for Therapeutic Products (Swissmedic), the Taiwan Food and Drug Administration (TFDA), the Australian Therapeutic Goods Administration (TGA), the European Directorate for the Quality of Medicines & HealthCare (EDQM) (Observer) and the Prequalification Team (PQT) of the World Health Organization (WHO), which includes the PQT–Medicines (Observer). Results. Although there were many similarities among the participating agencies surveyed, there were also differences that should be discussed such as assessment processes of ASMFs/DMFs and Technical requirements for APIs. Conclusions. These differences revealed by this survey will be key considerations in order to facilitate the filing of ASMFs/DMFs globally and to establish a framework for sharing and utilizing information related to ASMFs/DMFs among IGDRP members in the future. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.
Constitutional and legal protection of intangible cultural heritage objects in Russia: Problems and prospects of development
Authors:   Saratov State University, Chulisova Yulia A.
Published: March 2022

Introduction. The complexity of determining the objects of intangible heritage and establishing organizational and legal mechanisms for their protection is due to the fact that we are talking about non-materialized processes and phenomena for which it is impossible to accurately calculate the degree of preservation. This is how they differ from traditional museum objects and monuments of culture and art, therefore, it is difficult to develop a set of measures aimed at their conservation. Theoretical analysis. A comparative legal analysis of the definitions of intangible heritage in the Convention and the Model Law of the CIS countries allows us to conclude that there is a conceptual teleological difference in approaches to understanding intangible heritage that should be protected: exclusively empirical, in which any manifestation of folk culture that has uniqueness and originality is protected; complex, including axiological, ethical, normative and empirical aspects, assuming a certain assessment of various traditions, customs, folklore heritage, plots and images. Empirical analysis. Consideration of federal legislation has revealed the fragmentary nature of the norms governing relations for the preservation, popularization and development of the intangible cultural heritage of the peoples of the Russian Federation. The absence of a single legal concept of “intangible cultural heritage” is a significant gap in the current legislation on culture and does not contribute to the effective protection of its objects. The envisaged Register (catalog) of Intangible Heritage Objects of the Peoples of the Russian Federation is at the initial stage of its formation. Results. According to the results of the study, the author concludes that it is currently necessary to develop a unified concept for the protection of intangible cultural heritage, which would combine unified universal approaches to the protection of the intangible cultural heritage of the peoples of Russia and the specifics of their protection, taking into account the uniqueness and originality of objects, and would contribute to increasing interest of people of such culture in its preservation and popularization.
Ensuring the environmental rights of Russian citizens is a priority direction of the state’s environmental policy
Authors:   Saratov State University, Averyanova Natalja N.
Published: March 2022

Introduction. Decent and safe life and activities of Russian citizens can only be possible in the favorable environment. The constitutional and legal guarantee in this area is the consolidation of the environmental rights of Russian citizens as a constitutional value, and its provision is a priority task of the state and, accordingly, the most important direction of the implemented environmental policy. Theoretical analysis. The author determines the constitutional and legal content of environmental rights of Russian citizens, reveals their significance for citizens and peoples living on the territory of Russia, identifies trends, prospects and problems of their implementation and development, the role of public authorities in this process. Empirical analysis. The researcher claims that the right of citizens to participate in the management of state affairs in the environmental sphere is implemented in various forms, of which an environmental referendum should be recognized the most effective, since its results are binding on public authorities. Despite this, environmental referendums are not often held. The reasons for this are, on the one hand, the unwillingness of the authorities to listen to the opinion of the population when delivering commercially successful projects, on the other hand, the complexity of the legally established procedure for holding a referendum. Results. It is proved that the right to the favorable environment is the main comprehensive constitutional environmental right, with other constitutional environmental rights being the means of its implementation, or restoration in case of violation. It is concluded that the problems associated with the realization of human rights arise from imperfections in the field of law-making, law enforcement, as well as systemic problems of the state structure of Russia. It is pointed out that there is a need to develop state environmental policy in terms of strengthening legal, organizational and other measures aimed at more effective implementation of environmental rights of Russian citizens.
Protection of historical memory as an institution of constitutional law: Russian and foreign experience
Authors:   Saratov State University, Kulikova Svetlana A. , Kirnosov Ivan D. ,   Saratov State University
Published: March 2022

Introduction. Identification and analysis of factors influencing the transformation of the main institutions of constitutional law, the emergence and development of new constitutional and legal institutions are considered to be an urgent problem for the science of constitutional law. One of the dynamically developing institutions of constitutional law is, in our opinion, the protection of historical memory. The article uses formal legal, historical and comparative methods. Their application will allow for a comprehensive study of the constitutionalization of state memorial policy in Russia and abroad. Theoretical analysis. The protection of historical memory is a multi-component constitutional and legal institution that includes at least three levels: creation and consolidation of the state memorial concept (national image of history); preservation of historical heritage; protection of historical memory from encroachments and distortion. The authors study them in more detail, first, by examining constitutional law of foreign states, and, then, by looking at the constitutional law of the Russian Federation. Empirical analysis. The research into constitutional and legal acts of foreign countries makes it possible to identify a steady tendency towards increasing social and political significance of understanding one’s own national history, which contributes to the formation of a constitutional and legal institution for the protection of historical memory in many foreign countries. Legislation aimed at protecting historical memory was gradually being formed in Russia, including both measures of positive legal regulation and prohibitions on publicly challenging historical facts related to the Second World War. The task of developing a unified political and legal concept of the national image of history and its constitutional and legal legalization turned out to be more difficult. Results. The establishment of the state memorial concept at the constitutional level is aimed at solving the tasks of determining the axiological foundations of development of society, formation of national identity, preservation of cultural identity and spiritual and informational sovereignty. The high social significance of regulated public relations, their relative isolation and internal structural unity give reason to conclude that a new constitutional and legal institution for the protection of historical memory is being formed. This process is typical of both Russia and foreign countries. The controversial issues of the formation of this institution are related to its relationship with the already established principles and institutions of constitutional law.
Adolescentes en riesgo: Búsqueda de sensaciones, adicción al internet y procrastinación
Authors: Morales Rodríguez Marisol
Published: March 2022

El objetivo del estudio fue caracterizar las conductas de riesgo búsqueda de sensaciones, adicción al internet y procrastinación en adolescentes y determinar la relación entre las variables de estudio. El método se enmarca en el enfoque cuantitativo, diseño no experimental, alcance descriptivo-correlacional. Participaron 702 adolescentes escolarizados con edad promedio de 14.9 años. Los instrumentos utilizados fueron la Escala Búsqueda de sensaciones, Forma V (Zuckerman, Eysenck & Eysenck, 1978; adaptación de Pérez & Torrubia, 1986), Cuestionario de Experiencias Relacionadas con el Internet de Beranuy, Chamarro, Graner y Carbonell (2009) y Escala de Procrastinación General (Busko, 1998), aplicándose previo consentimiento de los padres. Los resultados destacan que los adolescentes incurren en conductas de riesgo como búsqueda de experiencias novedosas y arriesgadas, adicción al internet y presentan conductas dilatorias. Tales conductas se encuentran vinculadas entre sí, colocando al adolescente en una condición altamente vulnerable, que puede generar consecuencias nocivas en su salud psicológica.
Prevalencia del Trastorno por Estrés Postraumático TEPT y eventos asociados en víctimas del desplazamiento forzado en la ciudad de Montería
Authors: Cabas Hoyos Kattia , Villamil Benítez Ilse , Uribe Urzola Alicia , Otero S. Carmen Rosa , González Bracamonte Yaninis
Published: March 2022

El desplazamiento forzoso en Montería puede convertirse en un factor de riesgo para la existencia de Trastorno por Estrés Postraumático (TEPT), sin embargo, no existen datos de prevalencia del mismo. El objetivo de la investigación fue identificar la prevalencia del TEPT y eventos asociados en adultos que sufrieron desplazamiento y están reasentados en esta ciudad. Participaron 117 adultos (n = 72 mujeres; n = 45 hombres) víctimas del desplazamiento. Para evaluar los eventos asociados al trauma fue empleada la Clinician Administred PTSD Scale CAPS y el PTSD Checklist PCL-C. Se analizaron eventos ocurridos y presenciados por los individuos. Los resultados mostraron que el 26.49% de la muestra cumplió criterios clínicos de TEPT. Los resultados son consistentes con la literatura existente y establecen un punto de referencia para futuros estudios, así como para el planeamiento de proyectos e intervenciones focalizados en la salud mental de esta población.
Selektywna analiza problemu publikacji humanistów i przedstawicieli nauk społecznych w języku angielskim
Authors: Wagner Izabela
Published: March 2022

Artykuł porusza problematykę publikacji w języku angielskim prac humanistów i przedstawicieli nauk społecznych wykształconych i prowadzących badania na gruncie języka polskiego. Analizując ten problem z perspektywy socjologii karier, okazuje się, że proces publikacyjny zdeterminowany jest nie tylko kryteriami merytorycznymi, ale także niemerytorycznymi, jak przynależność do ośrodka naukowego, kultura dyscyplinarna czy też obszar referencji i posiadanej wiedzy, nie w sensie jakości, ale jej specyfiki (odwoływanie się do określonego paradygmatu czy specyficznej literatury naukowej). Na podstawie badań etnograficznych i autoetnograficznych wykazano, iż powierzchowne traktowanie kwestii strategii publikacyjnych, utrzymujące zasadność i priorytet publikowania w języku angielskim, wynika z nieznajomości socjologicznych elementów procesu publikacyjnego i mechanizmów karier naukowych realizowanych w obszarach języków narodowych (w odróżnieniu od tych dziedzin, w których językiem technicznym jest język angielski).
Analysis of Primordia and Fruiting Forming Days on using Different Sterilization Techniques of Straw and its Effect on Yield of Blue Oyster Mushroom
Authors: Shreejana K.C. , Kurunju Kabita , Thapa Ronika , Ghimire Shirish , Shrestha Pradeep
Published: March 2022

Background: Mushroom is a typical fungi having spore bearing fruiting bodies without chlorophyll in them. Due to its high nutritive and medicinal value, it is being popular among the public.
Methods: The research was conducted in laboratory condition of Mahendra Gram Secondary School, Bhaktapur; under control environmental condition to evaluate primordial formation and yield analysis of oyster mushroom Pleurotus florida using different sterilization techniques from March to July 2020.
Result: Earlier primordial formation was visualized in chemical method and higher yield was obtained from steaming method of sterilization. However, boiling method showed harsh result for all parameters as primordial formation, fruiting and yield. But still number of researches should be conducted for the exact evaluation of the yield performance.
PENGARUH MOTIVASI MENGHINDARI RIBA DAN PENGETAHUAN PRODUK KOPERASI SYARIAH TERHADAP KEPUTUSAN MENJADI NASABAH DI KOPERASI SIMPAN PINJAM PEMBIAYAAN SYARIAH (KSPPS) NUR HAYYU AMBARA NTB
Authors: Utomo Danang Prio , Jailani Huzain , Cahyati Regita Ayu
Published: March 2022

This study aims to analyze partially and simultaneously the effect of the motivation to avoid usury and knowledge of sharia cooperative products on the decision to become a customer in the Sharia Savings and Loans Payment Cooperative Nur Hayyu Ambara NTB. This study uses quantitative methods. The sampling technique is Non Probability Sampling with Incidental Sampling sampling technique. The number of respondents in this study were 60 respondents. Data collection using a questionnaire and then processed using SPSS 16. Data analysis techniques using validity test, reliability test, classical assumption test, multiple linear regression test, partial test (t test), simultaneous test (f test), and coefficient of determination test (R2). The results of this study indicate that partially the motivation to avoid usury has no significant effect on the decision to become a customer of the Sharia Savings and Loans Payment Cooperative Nur Hayyu Ambara,  The results of the coefficient of determination (R2) show that the influence of motivation to avoid usury and product knowledge on the decision to become a customer of the Sharia Savings and Loans Payment Cooperative Nur Hayyu Ambara NTB is 31.1% while the remaining 69.9% is influenced by factors outside the model
A PANEL DATA ANALYSIS OF FACTORS PUSHING GDP OF MALAYSIA: A RESEARCH ON SELECTED ECONOMIC INDICATORS
Authors: Chopra Monika
Published: March 2022

Introduction: From time immemorial, the policy emphasis has always been on Gross Domestic Product (GDP) since it is the measure of wellbeing. Every country's budget is intended to move the economy in the right direction by promoting economic development.

Objective: The study is performed to analyse the long-term impact of select economic indicators from available literature review on economic growth of Malaysia.

Methodology: For meeting the research objective a panel data is famed through data collection from official website of world bank. After collecting data of selected indicators, research tools namely- mean, standard deviation, ANOVA and regression are applied.

Value: The study will lead to an understanding of which important element affects GDP and allows the policymakers to focus their attention on factors relevant to the goal of raising GDP.
THE RISK FACTORS OF HYPERTENSION IN INDONESIA (DATA STUDY OF INDONESIAN FAMILY LIFE SURVEY 5)
Authors: Khasanah Dewi Nur
Published: March 2022

ABSTRACTBackground: Hypertension is a worrying disease, as it often does not cause symptoms. According to WHO, this disease affects 22% of the world's population, while hypertension has affected 25% of the population in Southeast Asia. In Indonesia, the prevalence of hypertensive disease increases from year to year. The suspected risk factors for hypertension are gender, age, genetics, smoking obesity, physical activity, and stress. Purpose: analyze factors that affect the prevalence of hypertension in Indonesia based on Indonesian Family Life Survey (IFLS) 5 data. Method: this study uses secondary data from Indonesia Family Life Survey (IFLS) 5 with a type of analytical observational research with cross sectional design. There were 4790 respondents who sampled research from 34,239 population. The analysis used is bivariate and multivariate. Results: bivariate analysis using chi-square test obtained factors related to hypertension incidence is gender (p=0,000), age (p=0.000), employment status (p=0.003), physical activity (p=0.011); and obesity (p=0.000). While through the test of logistic regression factors that affect hypertension is gender (p=0,000), age(p=0.000), physical activity(p=0.015), and obesity(p=0.000). Conclusion: factors that affect the incidence of hypertension are gender, age, physical activity, and obesity. ABSTRAK Latar Belakang: Hipertensi merupakan penyakit yang menghawatirkan, karena penyakit ini sering tidak menimbulkan gejala. Menurut WHO penyakit ini menyerang 22% penduduk di seluruh dunia, sedangkan penyakit hipertensi telah menyerang 25% penduduk wilayah Asia Tenggara. Di Indonesia, prevalensi penyakit hipertensi meningkat dari tahun ke tahun. Adapun yang diduga menjadi faktor risiko hipertensi yaitu jenis kelamin, umur, genetik, obesitas merokok, aktifitas fisik, dan stress. Tujuan: menganalisis faktor yang mempengaruhi kejadian hipertensi di Indonesia berdasarkan data Indonesian Family Life Survey (IFLS) 5. Metode: penelitian ini menggunakan data sekunder dari Indonesia Family Life Survey (IFLS) 5 dengan jenis penelitian observasional analitik dengan desain cross sectional. Terdapat 4790 responden yang menjadi sampel penelitian dari 34.239 populasi. Analisis yang digunakan adalah bivariat dan multivariat. Hasil: analisis bivariat yang menggunakan uji chi-square didapatkan faktor yang berhubungan dengan kejadian hipertensi adalah jenis kelamin (p=0,000); umur (p=0,000); status pekerjaan (p=0,003); aktifitas fisik (p=0,011); dan obesitas (p=0,000). Sedangkan melalui uji regresi logistik faktor yang berpengaruh terhadap hipertensi adalah jenis kelamin (p=0,000), umur (p=0,000), aktifitas fisik (p=0,015), dan obesitas(p=0,000). Kesimpulan: faktor yang berpengaruh terhadap kejadian hipertensi adalah jenis kelamin, umur, aktifitas fisik, dan obesitas.
A Standardized Nomenclature and Atlas of the Female Terminalia of Drosophila melanogaster
Authors: McQueen Eden W. , Afkhami Mehrnaz , Atallah Joel , Belote John M. , Gompel Nicolas , Heifetz Yael , Kamimura Yoshitaka , Kornhaeuser Shani C. , Masly John P. , O’Grady Patrick , Peláez Julianne , Rebeiz Mark , Rice Gavin , Sánchez-Herrero Ernesto , Santos Nunes Maria Daniela , Santos Rampasso Augusto , Schnakenberg Sandra L. , Siegal Mark L. , Takahashi Aya , Tanaka Kentaro M. , Turetzek Natascha , Zelinger Einat , Courtier-Orgogozo Virginie , Toda Masanori J. , Wolfner Mariana F. , Yassin Amir
Published: March 2022

The model organism Drosophila melanogaster has become a focal system for investigations of rapidly evolving genital morphology as well as the development and functions of insect reproductive structures. To follow up on a previous paper outlining unifying terminology for the structures of the male terminalia in this species, we offer here a detailed description of the female terminalia of D. melanogaster. Informative diagrams and micrographs are presented to provide a comprehensive overview of the external and internal reproductive structures of females. We propose a collection of terms and definitions to standardize the terminology associated with the female terminalia in D. melanogaster and we provide a correspondence table with the terms previously used. Unifying terminology for both males and females in this species will help to facilitate communication between various disciplines, as well as aid in synthesizing research across publications within a discipline that has historically focused principally on male features. Our efforts to refine and standardize the terminology should expand the utility of this important model system for addressing questions related to the development and evolution of animal genitalia, and morphology in general.
Modeling Spatial Local Variations in Intermarriage
Authors: Esteve Albert , Chasco Coro , López-Gay Antonio
Published: March 2022

We utilized all Spanish marriage records available at the municipality level from 2005-2007 to model spatial variations in intermarriage. We constructed a spatial regime zero inflated Poisson model and grouped-data probit model, with spatially lagged regressors, to predict the absolute and relative presence of intermarriage between Spaniards and migrants based on structural characteristics of the local marriage markets and their neighboring areas (i.e., relative group size, homogeneity of national origins, and sex ratio indicators). Our models do not assume collapsibility of the marriage market. Instead, they incorporate the local dimension of the marriage market and examine the association between intermarriage and structural variables at the spatial local level. The model also investigates intermarriage variation by size of place. The local characteristics of the marriage markets are robust indicators of both the absolute and relative importance of intermarriage, but their impact varies by size of municipality. The relative size of the migrant community positively impacts intermarriage. The homogeneity of the origins of migrants is negatively related to it. The impact of sex ratios in the migrant and native communities on intermarriage is not uniform across all municipalities and is not always related to more intermarriage.
Could a Focus on the “Why” of Taxonomy Help Taxonomy Better Respond to the Needs of Science and Society?
Authors: Pritchard Leighton , Brown C. Titus , Harrington Bailey , Heath Lenwood S. , Pierce-Ward N. Tessa , Vinatzer Boris  A.
Published: March 2022

Genomics has put prokaryotic rank-based taxonomy on a solid phylogenetic foundation. However, most taxonomic ranks were set long before the advent of DNA sequencing and genomics. In this concept paper, we thus ask the simple yet profound question: Should prokaryotic classification schemes besides the current phylum-to-species ranks be explored, developed, and incorporated into scientific discourse? Could such alternative schemes provide better solutions to the basic need of science and society for which taxonomy was developed, namely, precise and meaningful identification? A neutral genome-similarity based framework is then described that could allow alternative classification schemes to be explored, compared, and translated into each other without having to choose only one as the gold standard. Classification schemes could thus continue to evolve and be selected according to their benefits and based on how well they fulfill the need for prokaryotic identification.
Trends of Treatment Development in Rheumatoid Arthritis: Promise, Progress, and Challenges
Authors: Jiang Ping , Wei Kai , Zhao Jianan , Jin Yehua , Chang Cen , Zhang Runrun , Xu Lingxia , Xu Linshuai , Shi Yiming , Guo Shicheng , Schrodi Steven J , He Dongyi
Published: March 2022

Rheumatoid arthritis (RA) is a chronic, systemic, abnormal inflammatory immune response. It is characterized by the involvement of the synovium and multiple organs and the destruction of joints and articular cartilage. In the past 30 years, several promising novel compounds and antibodies have been developed for the treatment of RA. The introduction of new drugs and precision medicine for all forms of RA raises several issues related to access to novel treatments by patients, optical regimen selection, cost-effectiveness, prognosis monitoring and outcome surveillance, particularly with regard to the development of low drug response rates, drug resistance and adverse side effects. Tremendous attention has been given to the identification of optimized drug combinations for the treatment of RA, particularly in early high-risk vulnerable and early individuals. Addressing these issues requires novel therapeutic approaches with new mechanisms and the establishment of accurate guidelines for drug selection, drug recombination, and non-chemical therapeutic efforts. In this study, we reviewed the most exciting recently established or ongoing novel drugs and approaches according to the clinical trial database maintained by the United States National Library of Medicine and discussed the trends in RA drug development and challenges in the treatment, providing a reference significant for the accurate treatment of RA and the research direction in the future.
Microbial Pattern and Antibiotic Resistance of Severe Pneumonia in A National Referral Hospital in Indonesia
Authors: Singh Gurmeet , Fauzi Nova Bornida , Masse Sudirman Fakhruddin , Aditianingsih Dita , Sugiarto Adhrie , Loho Tonny , Wulandari Dewi
Published: March 2022

Background: Patients hospitalized in the intensive care unit (ICU) have a higher susceptibility to infections. Respiratory infections are the most common nosocomial infections. Rising antibiotic resistance due to indiscriminate use of antibiotics and poor adherence to standard precaution in healthcare facilities compounds the problem. The main aim of this study is to assess microbial patterns and antibiotic resistance from bronchoalveolar lavage specimens in severe pneumonia patients. Methods: This retrospective study was conducted in an Indonesian tertiary care hospital from January 2016-December 2020. Written and verbal informed consent was obtained prior to bronchoscopy procedures. Patients were enrolled if they had severe community-acquired pneumonia (CAP) according to American Thoracic Society (ATS)/Infectious Disease Society of America (IDSA) criteria, had high-risk hospital-acquired pneumonia (HAP), late-onset ventilator-associated pneumonia (VAP), or pneumonia caused by Coronavirus disease (COVID-19). Respiratory specimens via bronchoscopy were inoculated on general semi-sloid thioglycolate media. Testing for antibiotic susceptibility was done using the disk diffusion method. Results: Two hundred and one patients’ data were analyzed. The majority of patients were males (65,17%) and above 60 years of age. The most common type of pneumonia was CAP (39,3%). Neurologic/cerebrovascular disease was the most common comorbidity (35,32%). Acinetobacter baumannii was the most frequently isolated microorganism. Ampicillin/sulbactam and amikacin were found to yield lower microbial resistance. Conclusion: Combination of ampicillin/sulbactam and amikacin appeared effective as initial empirical therapy in severe pneumonia patients. Further studies are needed to evaluate the feasibility and effectiveness of this combined therapy.
A Study on Anomaly Detection of Water-Soluble Coolant Using Internal-Sensors
Authors: Kondo Yasuo ,   Graduate School of Engineering, Yamagata University  4-3-16 Jonan, Yonezawa, Yamagata 992-8510, Japan, Miyake Youji
Published: March 2022

The quality of water-soluble coolant is managed based on the maintenance schedules provided by a manager including periodic replacement of coolant. Post-maintenance is adopted when an anomaly is detected in the daily measurements. However, the reliability of management is dependent upon on the competence and experience of an operator. Condition monitoring allows users to detect critical changes in a water-soluble coolant. In contrast to the conventional method, condition monitoring can be assumed to be continuous and remote using ICT technologies. In this study, the spindle motor and NC data were utilized as internal sensors to monitor the quality of water-soluble coolant. The signal obtained from this sensor system can be easily broadcasted to the Internet as digital data and extended to an automatic data analysis using AI and machine learning in the future. It can be stated that this study enhances continuous and remote monitoring of water-soluble coolant and has the possibility of monitoring the changes in sludge concentration and Brix%. However, the sensor data cannot be used as an absolute index to estimate the quality of water-soluble coolant. It is a valuable indicator only when it is analyzed in combination with other sensor data such as pH and Brix%. The method proposed in this study can be widely extended to monitor the condition of water-soluble coolant and cutting tools.
A Study on Demand Forecasting of Wholesale Markets of Lettuces for Production Planning in Plant Factories
Authors: Sugimura Nobuhiro , Thinh Nguyen Quang , Kohama Shohei , Fukui Yutaka , Iwamura Koji ,   Yamato University  2-5-1 Katayamacho, Suita, Osaka 564-0082, Japan,   Osaka Prefecture University, Sakai, Japan,   IHI Corporation, Tokyo, Japan
Published: March 2022

Much emphasis is now being placed on the research and development of fully closed and controlled plant factories aimed at supplying fresh vegetables safely and constantly. Plant factories produce large volumes of clean and safe vegetables in an artificially controlled environment. One of the important issues in the management and control of plant factories is establishing systematic methods for planning the production and shipping of daily produced vegetables to various customers, such as supermarkets, vegetable shops, and restaurants. Customer demand is influenced by the sales in the individual shops and trade volumes, and prices in the wholesale markets of the vegetables, since the share of the plant factory-made vegetables is very small. Systematic methods are required for the management and control of plant factories to forecast both orders from individual customers and wholesale market conditions. In the previous study, the market situations and the trading processes of the factory-made lettuces were investigated, and a market model was proposed to simulate the trading processes between the customers and the plant factories. This study deals with demand forecasting of wholesale markets for vegetables, aimed at taking into consideration the wholesale market conditions for production planning in plant factories.
WEAR RESISTANCE OF HARD TURNED SURFACES
Authors: Molnár Viktor
Published: March 2022

The quality of working surfaces plays an important role in automotive industrial components. One of the main characteristics of such surfaces is their wear resistance. In this study external cylindrical surfaces were analyzed. A Design of Experiment methodology was applied and hard turning experiments were carried out to analyze the effects of the cutting parameters on the 3D surface roughness values of reduced peak height, skewness and kurtosis. The study confirmed earlier findings that at lower feed the wear resistance is higher based on the analyzed roughness parameters. The cutting speed and the depth-of-cut do not influence these parameter values significantly.
THE RALATIONSHIP BETWHEEN THE PARAMETERS OF ROUGHNESS AND FEATURES OF SURFACE FORMATION WITH A SPECIAL MICROPROFILE
Authors: Lavrinenko Valerii , Solod Volodymyr
Published: March 2022

This article shows the regularities of the formation of the relationship between the parameters of the roughness of the treated surface under the conditions of processing with a tool made of superhard materials. Features of formation of the ratio of height parameters of roughness Rmax/Ra for conditions of diamond-abrasive processing are shown. In general, in relation to Rmax/Ra we have a kind of "roughness arc", when first for a normal untreated rough source surface it is close to 4, then abrasive-diamond treatment of this surface raises this ratio to 6 and then to 8, but further methods of abrasive finishing and polishing reduce the ratio to 6 and then chemical-mechanical polishing to a high-quality surface returns this ratio to values close to 4. This means that if the initial cost of grinding the original surface affects the increase in the ratio, then the subsequent cost of finishing and polishing work reduces the value of the ratio Rmax/Ra to the original. The peculiarities of obtaining a treated surface with a special microprofile, which is a flat protrusions with recesses (a kind of "pockets") for placing oil to increase the service life of such a surface.
Hearables as a Gateway to Hearing Health Care: A Review
Authors: Seol Hye Yoon , Moon Il Joon
Published: March 2022

The market for hearing technology is evolving—with the emergence of hearables, it now extends beyond hearing aids and includes any ear-level devices with wireless connectivity (i.e., wireless earbuds). However, will this evolving marketplace bring forth opportunities or challenges to individuals’ hearing health care and the profession of audiology and otolaryngology? The debate has been ongoing. This study explores the wide spectrum of hearables available in the market and discusses the necessity of high-quality clinical evidence prior to the implementation of over-the-counter devices into clinical practice.
Распространение вариантов вируса SARS-COV-2, вызывающих озабоченность (VOC) и интерес (VOI) на основе количества их геномов, депонированных в базу данных GISAID за неделю с 26.02.2022 г. по 04.02.2022 г.
Authors: Дмитриева Людмила , Чумачкова Елена , Краснов Ярослав , Осина Наталья , Сафронов Валентин , Иванова Александра , Карнаухов Игорь , Караваева Татьяна , Щербакова Светлана , Кутырев Владимир
Published: March 2022

В обзоре представлен анализ геновариантов вируса SARS-CoV-2, вызывающих озабоченность (VOC) и интерес (VOI) на основе их геномов в базе GISAID за неделю с с 26.02.2022 г. по 04.02.2022 г.
The Influence of Gender, Religiosity, and Intellectual Intelligence on Ethical Perceptions of Accounting Students with Love of Money on Ethical Perceptions of Accounting Students
Authors: Riszqiya Dwi Afifatul , Maryanti Eny
Published: March 2022

This study aims to determine whether gender, religiosity, and intellectual intelligence have an influence on ethical perceptions of accounting students through love of money as an intervening variable at Muhammadiyah University of Sidoarjo and STIE Perbanas Surabaya. This type of research is quantitative, and obtained a sample of 90 respondents. The test tool uses smartPLS 3.0. The results of the study are: there is no effect of gender on ethical perceptions, religiosity has no effect on ethical perceptions, intellectual intelligence has an influence but is negative on ethical perceptions, gender has no influence on love of money, religiosity, intellectual intelligence has an influence on love of money, love of money has a negative influence on ethical perceptions, love of money has not been able to intervene for gender, religiosity, and intellectual intelligence with ethical perceptions.
The Relationship Between Religiusity And Affective Commitmen on Ikatan Mahasiswa Muhammadiyah
Authors: Aji Mohammad Thursin , Widyastuti Widyastuti
Published: March 2022

This research is a study of the phenomenon of affective commitment experienced by IMM students, Muhammadiyah University of Sidoarjo. The purpose of this study was to determine the relationship between religiosity and affective commitment in IMM students, Muhammadiyah University of Sidoarjo. The type of research used is quantitative research with a correlational approach. This study uses two variables, namely the religiosity variable as the independent variable and the affective commitment variable as the dependent variable. This research was conducted at the University of Muhammadiyah Sidoarjo on 172 IMM Students (Muhammadiyah Student Association) using the Convenience Sampling technique. The data collection technique used two psychological scales with a Likert scale model, namely the religiosity scale and the affective commitment scale. The results of the reliability coefficient of Alpha Cronbach's religiosity scale of 0.935 with a total of 35 valid items, while the results of the reliability coefficient of Alpha Cronbach's affective commitment scale of 0.957 with a total of 48 valid items. The analysis used is the Pearson Product Moment correlation analysis technique using the SPSS 20 for windows program. The results of the correlation coefficient analysis showed the results of 0.370 with a significance of 0.000. So that it is stated that there is a positive relationship between religiosity and affective commitment to IMM students, Muhammadiyah University of Sidoarjo, this shows that the initial hypothesis proposed by the researcher is accepted. The result of the effective contribution between the variables of religiosity and affective commitment is 13.7%.
Ismail Raji Al-Faruqi's Concept of Islamization of Perspective Science and Its Relevance for Islamic Education Curriculum
Authors: Wardana Dhiky Ary , Haryanto Budi
Published: March 2022

This article aims to add scientific references about the concept of Islamization of Ismail Raji Al-Faruqi's perspective of science and its relevance to the Islamic education curriculum, so that later if anyone looks for references on the concept of Islamization of Ismail Raji Al-Faruqi's perspective of science, there can be more, thus can make it easier for readers. The type of research used is library research where the data is obtained from the literature using a philosophical approach. The results of the study found that Ismail Raji Al-Faruqi's concept of Islamization of science is with 12 active steps so that it is hoped that there will be no dichotomy. And the relevance of Ismail Raji al-Faruqi's thoughts for the Islamic education curriculum can be seen in three meaningful points which are philosophically stated so that there is relevance for the quality of the Islamic education curriculum.
Readiness of Early Childhood Learning at Integrated Raudhatul Athfal Islam Insan Kamil during the Covid 19 Pandemic
Authors: Purwaningtyas Aprilliana , Affandi Ghozali Rusyid
Published: March 2022

The research method used is descriptive quantitative type which was carried out at Raudhatul Athfal Islam Terpadu Insan Kamil, Sidoarjo. The population in this study were 75 children using purposive sampling. This study used the NST test. The results of this study indicate that children's learning readiness during online learning at Raudhatul Athfal Islam Terpadu Insan Kamil, Sidoarjo indicates that children's online learning readiness is 29% ready, 32% quite ready, and 39% not ready. The comparison of male students' learning readiness is 43.14% greater than female students' which is only 41.86%. The highest aspect comparison among the 10 aspects, the highest is aspect 1 with an average score of 5.17 and the lowest is in the fifth aspect with a value of 3.96. Comparison of each aspect in terms of gender, male has the highest score in aspect 1 with an average score of 5.43 which is higher than female with a score of 4.64. Meanwhile, the highest score for women is in the eighth aspect with a score of 4.43 which is higher than that of men, which is only 4.14. Overall, it can be concluded that online learning has an effect on learning readiness at Raudhatul Athfal Islam Terpadu Insan Kamil, Sidoarjo with the result of poor learning readiness. The results of this study recommend to schools to provide parenting and to parents to supervise the children's learning process while online.
Patterns of Islamic Education in Child Care Services in Kejapanan Village, Gempol District, Pasuruan Regency
Authors: Ilham Mardhiana Amalia Dessy Fadzrina , Hariyanto Budi
Published: March 2022

This research is a descriptive research type, and the type of approach used is qualitative. In the book by Sukmadinata, it explains that "Descriptive research with a qualitative approach is a descriptive qualitative narrative of the situation". A qualitative approach is research which will then produce the results of analytical procedures that do not use statistical analysis studies. The main objective of the research is obtain data, therefore the main step that must be taken in a study is data collection. In Kejapanan village there are several day care centers for children among others, a day care center that is cared for by Mrs. Sriati and a day care center that is cared for by Ms. Safa'ah. In Mrs. Safa'ah's daycare, there were no signs of education for children related to Islamic values, whereas where there is a form of education for children based on Islamic values with the form of teaching daily prayers, singing Islamicsongs.
Journal of the Relationship Between Social Support and Achievement Motivation in High School Students
Authors: Juha Juan Bobby Arief Nugraha , Ansyah Eko Hardi
Published: March 2022

Achievement motivation is a determinant of student achievement, students should have high achievement motivation regardless of the circumstances, when motivation for achievement is low, it will affect student achievement. Therefore it is necessary to look for factors that influence achievement motivation. This study aims to determine the relationship between social support and achievement motivation and how much influence social support has on achievement motivation on students at the AL-Islam Krian High School Sidoarjo. This research was conducted with a quantitative correlational research method, using proportional sampling. with a sample of 382 students. The measurement tool uses two scales, namely social support scale and achievement motivation scale using the Spearman product moment correlation technique with the help of IBM Statistics 20 Version for Windows. The results of the analysis show that there is a relationship between social support and achievement motivation. The implication of this research is to develop student achievement and provide interventions to improve the quality of education. Increasing the quality of education to the maximum can increase social support and achievement motivation in students.
(Un-)Sichtbares Design und ‹Gesten der Freiheit›
Authors: Donner Martin
Published: March 2022

Im Rahmen von Digitalisierung und ubiquitous computing kommt dem Thema Design eine zentrale Rolle zu. Vor dem Hintergrund von Lucius Burckhardts Idee eines unsichtbaren ‹Soziodesigns› schlägt der Text vor, sich dem Thema zunehmend ubiquitärer Interfaces in pragmatischer Hinsicht über die Gestenrepertoires zu nähern, die mit ihnen realisiert werden, und in denen – so die These – das Unsichtbare des Designs sichtbar wird. Dabei eröffnet der von Rancière entlehnte Begriff des ‹Sinnlichkeitsregimes› eine fruchtbare Perspektive auf eine Ebene nichtsprachlicher Körperpolitik. Illustriert werden diese Zusammenhänge anhand eines kurzen exemplarischen Einblicks in zwei Fälle des BMBF-Verbundprojekts Musikalische Interface-Designs: Augmentierte Kreativität und Konnektivität. Vor dem Hintergrund der dargelegten Perspektive wird schliesslich erläutert, wie eine integrative Kulturelle Bildung dazu beitragen könnte, digitale Souveränität zu fördern.
Relationship between the transcriptional activity of СT-genes and survival in colorectal cancer patients
Authors: Kutilin D. S. , Kit O. I.
Published: March 2022

Introduction. High incidence and mortality rates of colorectal cancer indicate an urgent need for the use of new highly specific diagnostic and prognostic molecular markers. In this aspect, cancer testis antigens (CTA s) are of particular interest.

The aim of the study was to analyze the relationship between the transcriptional activity of CTA s and survival in colorectal cancer patients with metastases (T1–4N1–2M1–2) and without metastases (T1–3N0M0).

Results. The relative expression of 16 genetic loci (MAGE-A1, MAGE-A2, MAGE-A3, MAGE-A4, MAGE-B1, MAGE-B2, GAGE-1, GAGE-3, GAGE-4, MAGE-C1, BAGE, XAGE3, NYESO1, SSX2, SCP1 and PRAME1) was determined by real-time PC R. In colorectal cancer patients having no metastases, the expression of SSX2 and PRAME1 genes was significantly higher and the expression of BAGE was significantly lower in colon tumor tissue than in normal tissue (p<0.05). In colorectal cancer patient with metastases, the expression of GAGE1, SCP1 and PRAME1 genes was significantly higher and the expression of MAGEA2, MAGEB1, MAGEB2, GAGE4 and NY-ESO1 genes was significantly lower in colon tumor tissue than in normal tissue (p<0.05). The expression of the GAGE1, BAGE, SSX2, MAGEA2, SCP1 and MAGEB1 genes was found to have a significant impact on the overall survival and the development of distant metastasis (p<0.05).

Conclusion. The data obtained are the basis for the formation of a panel of effective immunotherapeutic targets and prognostic markers for colorectal cancer patients with and without metastases.