bluuebunny/crossref_metadata_2025 huggingface dataset:
Proteome profiling and vector yield optimization in a recombinant adeno‐associated virus‐producing yeast model
Authors: Aponte‐Ubillus Juan Jose , Barajas Daniel , Sterling Harry , Aghajanirefah Ali , Bardliving Cameron , Peltier Joseph , Shamlou Parviz , Roy Mimi , Gold Daniel
Published: November 2020

Recent studies on recombinant adeno‐associated viral (rAAV) vector production demonstrated the generation of infectious viral particles in Saccharomyces cerevisiae. Proof‐of‐concept results showed low vector yields that correlated with low AAV DNA encapsidation rates. In an attempt to understand the host cell response to rAAV production, we profiled proteomic changes throughout the fermentation process by mass spectrometry. By comparing an rAAV‐producing yeast strain with a respective non‐producer control, we identified a subset of yeast host proteins with significantly different expression patterns during the rAAV induction period. Gene ontology enrichment and network interaction analyses identified changes in expression patterns associated mainly with protein folding, as well as amino acid metabolism, gluconeogenesis, and stress response. Specific fold change patterns of heat shock proteins and other stress protein markers suggested the occurrence of a cytosolic unfolded protein response during rAAV protein expression. Also, a correlative increase in proteins involved in response to oxidative stress suggested cellular activities to ameliorate the effects of reactive oxygen species or other oxidants. We tested the functional relevance of the identified host proteins by overexpressing selected protein leads using low‐ and high‐copy number plasmids. Increased vector yields up to threefold were observed in clones where proteins SSA1, SSE1, SSE2, CCP1, GTT1, and RVB2 were overexpressed. Recombinant expression of SSA1 and YDJ insect homologues (HSP40 and HSC70, respectively) in Sf9 cells led to a volumetric vector yield increase of 50% relative to control, which validated the importance of chaperone proteins in rAAV‐producing systems. Overall, these results highlight the utility of proteomic‐based tools for the understanding and optimization of rAAV‐producing recombinant strains.
UV‐induced DNA damage response in blood cells for cancer detection
Authors: Farivar Negin , Roberts Morgan E. , Safaee Ardakani Gholamreza , Black Peter C. , Daugaard Mads , Taghipour Fariborz
Published: November 2020

Detection and diagnosis of cancer often require a combination of tests that are inconvenient and invasive for patients. There is therefore a need for new simple non‐invasive tests able to detect cancer at various stages. Here, a novel photochemical assay for cancer detection in liquid biopsies is described. This proof of concept study shows that the response of peripheral blood mononuclear cells (PBMCs) to light‐emitting diode (LED)‐transmitted UV radiation can be used as an indicator of malignant disease. When exposed to UVB/C radiation, isolated PBMCs from prostate cancer patients presented with an acute dose‐dependent DNA damage response that is distinct from that of PBMCs from healthy individuals. Importantly, this assay achieves sensitivity and specificity comparable to standard methods currently in clinical use. In summary, this work demonstrates that photochemical interrogation of PBMCs from cancer patients can be utilized for detection of malignant diseases. As such, the assay could potentially complement current gold standard cancer detection strategies for the benefit of patients and healthcare economy.
Free extended posterior tibial artery perforator flap with the neurovascular plexus of a saphenous nerve branch for large soft tissue and sensory reconstruction: Anatomic study and clinical application
Authors: Liu Xuanzhe , Sun Yi , Jia Yachao , Hong Sung Min , Xu Jia , Wang Chunyang , Wen Gen , Lineaweaver William C. , Chai Yimin
Published: November 2020

Background

The posterior tibial artery perforator (PTAP) flap is a useful tool for reconstruction of soft tissue defects in the leg. However, the size and reliability of the flap largely depends on the quality of the perforator by which the flap is supplied, and the sensory recovery of the flap is limited. In this study, the anatomy of the saphenous nerve branches and their accompanying vessels was investigated, and a free extended PTAP flap with the neurovascular plexus of a saphenous nerve branch was designed for large soft tissue and sensory reconstruction in a series of clinical cases.

Methods

Sixteen adult cadaveric legs perfused with red latex in the femoral artery were dissected. The number and location of the saphenous nerve branches and the features of their accompanying vessels were dissected and studied. From January 2016 to December 2017, six patients with soft tissue defects ranged from 8 × 2.5 cm to 21 × 4 cm were repaired by the free extended PTAP flap. The patients' average age was 48 years. The causes of the defects included machine injuries in three patients and traffic injuries in the other three. The defects located at the hand in three cases, foot in two cases, and ankle in one case. The flap was designed based on the perforators of the posterior tibial artery and included a branch of saphenous nerve. The perforator pedicle and the nerve branch were connected to the vessels and nerve in the recipient site, respectively.

Results

The saphenous nerve gave off 5.8 ± 1.1 branches, with a relatively constant one issuing 8.1 ± 0.7 cm distal to the medial femoral condyle. Every nerve branch had an accompanying vessel, which connected with the PTAPs and supplied the skin. The size of the flap ranged from 10 × 3.5 cm to 23 × 5 cm. All of the flaps survived completely without complications. Follow‐up varied from 6 to 12 months. All the patients obtained cold/hot sensation and pain sensation. The results of Semmes–Weinstein monofilament test ranged from 4.31(2 g) to 5.46 (26 g), and the 2‐point discrimination test varied from 20 to 35 mm.

Conclusion

The free extended PTAP flap, containing the saphenous nerve branch and its accompanying vessels, may be an alternative for large soft tissue reconstruction with improved sensation recovery.
Internal mammary artery perforators as recipient vessels for free tissue transfer in head and neck reconstruction: A case report and literature review
Authors: Scaglioni Mario F. , Meroni Matteo , Fritsche Elmar , Rajan Gunesh
Published: November 2020

Head and neck defect reconstruction is a common challenge for plastic surgeons. Microsurgical free tissue transfer is a frequently used solution but its success strictly depends on the quality of recipient vessels. A particularly demanding situation occurs when there are no nearby available vessels because of previous extensive neck dissection and radiotherapy. In similar cases, it is necessary to resort to other and farther vessels. Common alternatives might be the thoraco‐acromial vessels, the transverse cervical vessels, and the internal mammary vessel. Recently, the perforator vessels of the internal mammary artery and vein were shown to be safe alternatives as recipient vessels for autologous breast reconstruction, causing less morbidity and allowing adequate perfusion of rather large flaps. Here we present a floor of the mouth reconstruction after cancer relapse resection. In this case, we employed a chimeric anterolateral thigh (ALT) free flap anastomosed to the internal mammary perforator vessels in end‐to‐end fashion. A 46‐years‐old male patient presented a defect in the floor of the mouth and base of the tongue after cancer removal. No nearby vessels were available because of extensive fibrosis and damages due to previous surgeries and radiotherapy. Therefore, on the basis of our experience in autologous breast reconstruction, we chose the internal mammary perforator vessels in the recipient side and we harvested a chimeric ALT‐based skin island then split into two parts for mouth reconstruction and monitoring. We performed the anastomosis resorting to internal mammary perforator vessels and we obtained a satisfactory result from both the functional and aesthetic point of view. Postoperative course was uneventful and at 6 months follow up the reconstructive result was good with no functional issue. We believe that this might be a valid and modern evolution of the use of internal mammary vessels as recipient vessels and that it is a worthy addition in the field of perforator‐anastomosed flaps, extending its application also to head and neck reconstructions. Moreover, a brief literature review about alternative recipient vessels for depleted neck is also provided.
Monitoring the psychological, social, and economic impact of the COVID‐19 pandemic in the population: Context, design and conduct of the longitudinal COVID‐19 psychological research consortium (C19PRC) study
Authors: McBride Orla , Murphy Jamie , Shevlin Mark , Gibson‐Miller Jilly , Hartman Todd K. , Hyland Philip , Levita Liat , Mason Liam , Martinez Anton P. , McKay Ryan , Stocks Thomas VA , Bennett Kate M. , Vallières Frédérique , Karatzias Thanos , Valiente Carmen , Vazquez Carmelo , Bentall Richard P.
Published: November 2020

Objectives

The C19PRC study aims to assess the impact of the COVID‐19 pandemic in the adult population of the UK, Republic of Ireland, and Spain. This paper describes the conduct of the first two waves of the UK survey (the “parent” strand of the Consortium) during March–April 2020.

Methods

A longitudinal, internet panel survey was designed to assess: (1) COVID‐19 related knowledge, attitudes, and behaviors; (2) the occurrence of common mental health disorders as well as the role of (3) psychological factors and (4) social and political attitudes, in influencing the public's response to the pandemic. Quota sampling (age, sex, and household income) was used to recruit a nationally representative sample of adults.

Results

Two thousand and twenty five adults were recruited at baseline, and 1406 were followed‐up one‐month later (69.4% retention rate). The baseline sample was representative of the UK population in relation to economic activity, ethnicity, and household composition. Attrition was predicted by key socio‐demographic characteristics, and an inverse probability weighting procedure was employed to ensure the follow‐up sample was representative of the baseline sample.

Conclusion

The C19PRC study data has strong generalizability to facilitate and stimulate interdisciplinary research on important public health questions relating to the COVID‐19 pandemic.
Efficient cardiomyocyte differentiation of induced pluripotent stem cells on PLGA nanofibers enriched by platelet‐rich plasma
Authors: Torabi Maryam , Abazari Mohammad Foad , Zare Karizi Shohreh , Kohandani Mina , Hajati‐Birgani Nazanin , Norouzi Sara , Nejati Fatemeh , Mohajerani Alireza , Rahmati Tahereh , Mokhames Zakiye
Published: November 2020

Regeneration and restoring the function of the myocardial‐infracted hearts have been one of the constant challenges in medicine. Recently, tissue engineering, using biocompatible substrates and stem cells, holds a real promise to solve these problems. Herein, poly(lactic‐co‐glycolic acid) (PLGA) nanofibers and platelet‐rich plasma (PRP) enriched PLGA nanofibers (PLGA‐PRP) were fabricated by electrospinning. Scanning electron microscopy (SEM) demonstrated that fiber diameters in PLGA scaffolds with and without PRP were in the range of 500 ± 280 nm and fibers were also bead free, smooth, in random orientation, and with interconnected pores. During culture of the human‐induced pluripotent stem cells (iPSCs) on the nanofibrous scaffold, further differentiation of the iPSCs to cardiomyocytes was detected in PLGA‐PRP nanofibers compared to the PLGA. This improvement in differentiation potential was evaluated at the morphological, molecular gene, and protein expression levels using SEM, real‐time reverse transcription‐polymerase chain reaction (RT‐PCR), and immunocytochemistry, respectively. The results obtained in this study highlighted the significance of natural growth factors present in the artificial scaffold applied in cardiac tissue engineering according to the improvements in cell‐biomaterial interactions. Taken together, our result indicated that PRP‐incorporated PLGA could be considered as a great potential candidate to use for engineering suitable myocardium replacement constructs.
Li‐decorated Al2C monolayer as a potential template for hydrogen storage: A first‐principles perspective
Authors: Rahimi Rezvan , Solimannejad Mohammad
Published: November 2020

The potential application of Li‐decorated Al2C template for hydrogen storage is researched by using periodic DFT computations. Based on the obtained results, pristine Al2C monolayer gets adsorb up to four H2 molecules that give hydrogen uptake capacities of 5.7 wt% with an average binding energy of 0.14 eV/H2. It is predicted that the decoration of Al2C monolayer with Li atoms significantly improves the hydrogen storage ability of the desired monolayer compared to that of pristine Al2C monolayer. This can be attributed to the polarization of H2 molecules induced by the charge transfer from Li atoms to Al2C monolayer. Decoration of Al2C monolayer with two Li atoms gives a promising medium that gets adsorb maximum of ten H2 molecules with hydrogen uptake capacities of 12.1 wt% and adsorption energies within the range of 0.24‐0.47 eV. It is inferred that hydrogen desorption from 2Li/Al2C(10H2) system can occur at TD = 313 K and P = 1 atm which is near to the ambient conditions. This is an important result indicating potential usage of 2Li/Al2C medium for hydrogen storage purposes.
Mnemonic strategy training modulates functional connectivity at rest in mild cognitive impairment: Results from a randomized controlled trial
Authors: Simon Sharon Sanz , Hampstead Benjamin M. , Nucci Mariana P. , Ferreira Luiz Kobuti , Duran Fábio L. S. , Fonseca Luciana M. , Martin Maria da Graça M. , Ávila Renata , Porto Fábio H. G. , Brucki Sônia M. D. , Martins Camila B. , Tascone Lyssandra S. , Jr. Edson Amaro , Busatto Geraldo F. , Bottino Cássio M. C.
Published: November 2020

Introduction

Mnemonic strategy training (MST) has been shown to improve cognitive performance and increase brain activation in those with mild cognitive impairment (MCI). However, little is known regarding the effects of MST on functional connectivity (FC) at rest. The aim of the present study was to investigate the MST focused on face‐name associations effect on resting‐state FC in those with MCI

Methods

Twenty‐six amnestic MCI participants were randomized in MST (N = 14) and Education Program (active control; N = 12). Interventions occurred twice a week over two consecutive weeks (ie, four sessions). Resting‐state functional magnetic resonance imaging was collected at pre‐ and post‐intervention. Regions of interest (ROIs) were selected based on areas that previously showed task‐related activation changes after MST. Changes were examined through ROI‐to‐ROI analysis and significant results were corrected for multiple comparisons.

Results

At post‐intervention, only the MST group showed increased FC, whereas the control group showed decreased or no change in FC. After MST, there was an increased FC between the left middle temporal gyrus and right orbitofrontal cortex. In addition, a time‐by‐group interaction indicated that the MST group showed greater increased FC between the right inferior frontal gyrus and left brain regions, such as fusiform gyrus, temporal pole, and orbitofrontal cortex relative to controls.

Discussion

MST enhanced FC in regions that are functionally relevant for the training; however, not in all ROIs investigated. Our findings suggest that MST‐induced changes are reflected in task‐specific conditions, as previously reported, but also in general innate connectivity. Our results both enhance knowledge about the mechanisms underlying MST effects and may provide neurophysiological evidence of training transfer.
Sonochemical Synthesis, Crystal Structure and Antimicrobial Property of One‐dimensional Dinuclear Coordination Polymer
Authors: Soltani Sajjad , Akhbari Kamran , White Jonathan
Published: November 2020

Dinuclear 1D coordination polymer of [NaCu2(pdc)2(H2O)4(OH)]n (1) (H2pdc = Pyridine‐2,6‐dicarboxylic acid) was synthesized by the solvothermal method, and its structure was investigated by single‐crystal X‐ray diffraction analysis. 1 has zigzag chains, which are converted to a 3D network through hydrogen bond interactions. Also, 1 was synthesized by sonochemical method (1‐Sono). The structures of 1 and 1‐Sono were characterized by FT‐IR, XRD, FE‐SEM and thermogravimetric (TG) techniques. Antibacterial activity was evaluated by agar well diffusion method. Release of copper ions, chelation, and stability were the factors influencing antibacterial property. More effect of compounds against S. aureus strain was observed, and 1‐Sono exhibited better antibacterial activity than 1.
Non-uniform crystallinity and temperature distribution during adjacent laser-assisted tape winding process of carbon/PA12 pipes
Authors: Hosseini S. M. Amin , Schäkel Martin , Baran Ismet , Janssen Henning , van Drongelen Martin , Akkerman Remko
Published: November 2020

The non-uniform temperature and crystallinity distributions present in carbon fiber–reinforced PA12 composite pipes, produced via laser-assisted tape winding (LATW), are investigated in this paper. The width of the laser source is usually larger than the substrate width which causes multiple heating and cooling of some regions of the (neighboring) substrate and hence temperature and crystallinity gradients during the adjacent hoop winding. A kinematic-optical-thermal (KOT) model coupled with a non-isothermal crystallinity model is developed to capture the transient temperature and crystallinity distributions for growing substrate thickness and width. The predicted temperature trends are validated with thermocouple and thermal camera measurements. The substrate temperature varies in the width direction up to 52%. This will lead to extra polymer remelting and possible degradation. The maximum variation of the crystallinity degree across the width is found to be 270% which shows agreement with the trend of the measured crystallinity degree. It is found that a more realistic description of the melting behavior of the matrix is needed to obtain a more accurate prediction of the crystallinity distribution.
Korevaar–Schoen’s directional energy and Ambrosio’s regular Lagrangian flows
Authors: Gigli Nicola , Tyulenev Alexander
Published: November 2020

We develop Korevaar–Schoen’s theory of directional energies for metric-valued Sobolev maps in the case of $${\textsf {RCD}}$$
RCD
source spaces; to do so we crucially rely on Ambrosio’s concept of Regular Lagrangian Flow. Our review of Korevaar–Schoen’s spaces brings new (even in the smooth category) insights on some aspects of the theory, in particular concerning the notion of ‘differential of a map along a vector field’ and about the parallelogram identity for $${\textsf {CAT}}(0)$$

CAT
(
0
)

targets. To achieve these, one of the ingredients we use is a new (even in the Euclidean setting) stability result for Regular Lagrangian Flows.
Evaluation of the “3 Good Questions” program for shared decision-making in pediatric medicine: a feasibility study
Authors: Rexwinkel Robyn , Rippen Hester , Blokzijl-Boezeman Inge J. M. , de Klein Zonja , Walhof Christel M. , van der Kraan Josine , Benninga Marc A. , Tabbers Merit M.
Published: November 2020

The “3 Good Questions” program was developed to increase shared decision making. The current pilot-study determined the feasibility of these questions to increase shared decision-making in Dutch pediatric medicine. Pre-/postintervention surveys were used to include children (10–18 years) at pediatric outpatient clinics of four hospitals in the Netherlands. After their appointment, two different groups of children completed the questionnaires. Group 1 filled in the survey before the intervention; group 2 completed the survey after active implementation of the “3 Good Questions” program. The primary outcome was to determine the feasibility (reach, applicability). Secondary outcomes were related to patient involvement in healthcare and treatment decisions and decision-making process between child and healthcare professional. In total, 168 and 114 children in groups 1 and 2 (61 vs 63% female, P = 0.68; age 13.3 ± 2.4 vs 13.8 ± 2.4 years, P = 0.72), respectively, completed the questionnaire. In group 2, 44% of children were aware of the “3 Good Questions”, of whom 18% posed ≥ 1 of the “3 Good Questions” during their appointment (feasibility). The “3 Good Questions” program led to more shared decision-making (SDM-Q-9: P = < 0.001;95%CI: − 2.43 to − 1.17). The majority of children who have read or heard of the “3 Good Questions” would recommend this program to other children.

Conclusion: Implementation of the “3 Good Questions” program seemed feasible, although it is necessary to further explore the implementation of this program at national level as a simple way for children and healthcare professionals to share decisions in practice.

What is known• Children have the right to be included in decision-making, and inclusion can improve patient satisfaction and quality of care, and reduce costs.• The “3 Good Questions” program was successfully implemented in adult healthcare to increase shared decision making, and therefore these “3 Good Questions” have been adapted to a child version.What is new• In this pilot study, we found that the implementation of the “3 Good Questions” program to increase shared decision-making in pediatric medicine seemed feasible. Although it is necessary to further explore the implementation of the “3 Good Questions” program at national level as a simple way for children and healthcare professionals to share decisions in practice.
Overcoming the social stigma of consuming food waste by dining at the Open Table
Authors: Edwards Ferne
Published: November 2020

Stigma is often encountered by recipients who receive food donations from charities, while the consumption of wasted food, also traditionally considered to be a stigmatized practice, has recently become part of a popular food rescue movement that seeks to reduce environmental impacts. These two stigmas—charitable donation and the consumption of waste—are brought together at the Open Table, a community group in Melbourne, Australia, that serves community meals cooked from surplus food. This paper examines how Open Table de-stigmatizes food donations through food waste discourse to enable greater social inclusion. I draw on the experiences of donors, cooks, volunteers and eaters gathered from diverse Open Table sites. Taking a ‘follow-the-thing’ approach, I analyze how food ‘waste’ becomes re-valued by embracing goals of environmental justice enacted through local processes of care and conviviality. Relying on networks of volunteers and not-for-profit agencies, Open Table provides a simple, effective and adaptable model for possible replication for overcoming drawbacks of traditional charity practices. Critically though, as hunger in society continues to grow, this approach is increasingly threatened by the need to ‘single out’ disadvantaged recipients to justify continued supply. This paper contributes to food poverty, waste, and Alternative Food Network literature in two important ways: first, by analyzing the outcomes of community food redistribution approaches with regards to stigma and inclusion; and secondly, by arguing that such holistic approaches need to be acknowledged, valued and supported to shift current discourses and practice.
An interior point-proximal method of multipliers for convex quadratic programming
Authors: Pougkakiotis Spyridon , Gondzio Jacek
Published: November 2020

In this paper we combine an infeasible Interior Point Method (IPM) with the Proximal Method of Multipliers (PMM). The resulting algorithm (IP-PMM) is interpreted as a primal-dual regularized IPM, suitable for solving linearly constrained convex quadratic programming problems. We apply few iterations of the interior point method to each sub-problem of the proximal method of multipliers. Once a satisfactory solution of the PMM sub-problem is found, we update the PMM parameters, form a new IPM neighbourhood and repeat this process. Given this framework, we prove polynomial complexity of the algorithm, under standard assumptions. To our knowledge, this is the first polynomial complexity result for a primal-dual regularized IPM. The algorithm is guided by the use of a single penalty parameter; that of the logarithmic barrier. In other words, we show that IP-PMM inherits the polynomial complexity of IPMs, as well as the strict convexity of the PMM sub-problems. The updates of the penalty parameter are controlled by IPM, and hence are well-tuned, and do not depend on the problem solved. Furthermore, we study the behavior of the method when it is applied to an infeasible problem, and identify a necessary condition for infeasibility. The latter is used to construct an infeasibility detection mechanism. Subsequently, we provide a robust implementation of the presented algorithm and test it over a set of small to large scale linear and convex quadratic programming problems. The numerical results demonstrate the benefits of using regularization in IPMs as well as the reliability of the method.
A survey of Big Data dimensions vs Social Networks analysis
Authors: Ianni Michele , Masciari Elio , Sperlí Giancarlo
Published: November 2020

The pervasive diffusion of Social Networks (SN) produced an unprecedented amount of heterogeneous data. Thus, traditional approaches quickly became unpractical for real life applications due their intrinsic properties: large amount of user-generated data (text, video, image and audio), data heterogeneity and high speed generation rate. More in detail, the analysis of user generated data by popular social networks (i.e Facebook (https://www.facebook.com/), Twitter (https://www.twitter.com/), Instagram (https://www.instagram.com/), LinkedIn (https://www.linkedin.com/)) poses quite intriguing challenges for both research and industry communities in the task of analyzing user behavior, user interactions, link evolution, opinion spreading and several other important aspects. This survey will focus on the analyses performed in last two decades on these kind of data w.r.t. the dimensions defined for Big Data paradigm (the so called Big Data 6 V’s).
A digital twins concept model for integrated maintenance: a case study for crane operation
Authors: Szpytko Janusz , Salgado Duarte Yorlandys
Published: November 2020

The paper presents an Integrated Maintenance Decision Making Model (IMDMM) concept for cranes under operation especially into the container type terminals. The target is to improve cranes operational efficiency through minimizing the risk of the Gantry Cranes Inefficiency (GCI) results based on the implementation of the Digital Twins concept for maintenance purposes. The proposed model makes a joint transportation process and crane maintenance scheduling, relevant to assure more robust performances in stochastic environments, as well as to assess and optimize performances at different levels, from components and transport device to production systems (container terminal). The crane operation risk is estimated with a sequential Markov chain Monte Carlo simulation model and the optimization model behind of IMDMM is supported through the Particle Swarm Optimization algorithms because the objective function a non-linear stochastics problem with bounded constrains. The developed model allows the container terminal operators (management process) to obtain a maintenance schedule that minimizes the GCI (holistic indicator), as well as establishing the desired level of risk. The paper demonstrates the effectiveness of the proposed maintenance decision making concept model for cranes under operation using data from of a real container terminal (case study).
Does It Take Two to Tango? Examining How Applicants and Interviewers Adapt Their Impression Management to Each Other
Authors: Wilhelmy Annika , Roulin Nicolas , Wingate Timothy G.
Published: November 2020

Although research has long examined applicants’ use of impression management (IM) behaviors in the interview, interviewers’ IM has only been recently investigated, and no research has attempted to combine both. The aim of this research was to examine whether and how applicants and interviewers adapt their IM to one another. To answer this question, we bring together IM, signaling theory, and the concept of adjacency pairs from linguistics, and carried out two studies. Study 1 was an observational study with field data (N = 30 interviews including a total of 6290 turns of speech by interviewers and applicants). Results showed that both applicants and interviewers are more likely to engage in IM in a way that can be considered as a “preferred” (vs. “dispreferred”) response pattern. That is, self-focused IM is particularly likely to occur as a response to other-focused IM, other-focused IM as a response to self-focused IM, and job/organization-focused IM as a response to job/organization-focused IM. In study 2, we used a within-subjects design to experimentally manipulate interviewer IM and examine its impact on (N = 120) applicants’ IM behaviors during the interview. Applicants who engaged more in “preferred” IM responses were evaluated as performing better in the interview by external raters. However, “preferred” IM responses were not associated with any other interview outcomes. Altogether, our findings highlight the adaptive nature of interpersonal influence in employment interviews, and call for more research examining the dynamic interactions between interviewers and applicants.
Unusually high sea level at the south coast of Japan in September 2011 induced by the Kuroshio
Authors: Usui Norihisa , Ogawa Koji , Sakamoto Kei , Tsujino Hiroyuki , Yamanaka Goro , Kuragano Tsurane , Kamachi Masafumi
Published: November 2020

Using a coastal assimilation model, generation mechanism of unusually high sea level (UHSL) at the south coast of Japan in September 2011 is investigated. Both model results and tide gauge observations indicate that sea level rise associated with the UHSL event occurred twice in the middle and end of September. The first one, which is localized around the eastern part of the Seto Inland Sea, is caused by a cyclonic circulation in the Kii Channel formed as a result of northward migration of the Kuroshio axis toward Cape Shionomisaki. The second sea level rise, which is the main contributor to this UHSL event, is observed in wide areas not only at the south coast of Japan, but also at the coast of the Japan Sea. It is brought about by a coastal trapped wave (CTW) induced as a result of a fluctuation of the Kuroshio path to the south of the Boso Peninsula. The CTW with positive SSH anomalies propagates westward along the south coast of Japan, and then goes into the coast of the Japan Sea. Sensitivity experiments and a modal characteristic analysis indicate that the CTW is mainly characterized by the first mode baroclinic Kelvin wave. The phase speed for the first mode is calculated at 2.96 m s$$^{-1}$$

-
1

, which compares well with that estimated by tide gauge observations.
Manual-Based Group Intervention for Siblings and Parents of Children with Neurodevelopmental Disorders in Cambodia
Authors: Fjermestad K. , Pat P. , Dearozet S. , Vatne T. , Hafting M. , Jegannathan B.
Published: November 2020

Siblings of children with neurodevelopmental disorders (ND) are at increased risk of mental health problems. The burden on families of children with ND is exacerbated in low-income countries with limited health services and dependency on informal care systems. Yet, there is little research on family impacts of ND in non-Western settings, and no evidence-based interventions for siblings. We examined initial outcomes and feasibility of a manual-based intervention for siblings and parents of children with ND, called SIBS, delivered in Cambodia. SIBS has promising evidence from an open trial in Norway. We delivered eight groups for 52 siblings (M age = 12.7 years, SD = 2.7; 44.0% female) and 56 caregivers (M age = 43.5 years, SD = 8.5; 61.1% mothers) of 54 children with ND at the only public child mental health clinic in Cambodia. We aimed to improve sibling and parent mental health and family communication. The SIBS intervention comprises three separate sibling/parent group sessions and two joint sibling-parent dialogue sessions. Parent-reported mental health scores for siblings were higher than sibling self-report. Parent mental health problems at baseline were high, with no difference between mothers and fathers. There was significant improvement in parent mental health and parent-rated mental health for siblings from baseline to 4-month post-intervention (effect sizes d = 0.44 to 0.52). There was no change in sibling-reported mental health or family communication. Sibling- and parent-rated user satisfaction was high. We conclude that the SIBS intervention showed promise in Cambodia. However, revision of the communication component is needed.
New companies’ DNA: the heritage of the past industrial revolutions in digital transformation
Authors: Martinelli Elisa Martina , Farioli Maria Cristina , Tunisini Annalisa
Published: November 2020

This paper debates the ongoing processes of digital transformation enhanced by the 4th industrial revolution in successful companies which have a long time business history and an international presence. The aim is analyzing how what they have experienced and learned in the 2nd and 3rd industrial revolutions represents key elements that have shaped their DNA and continue to inspire their transformation to the point that the gradual radical change concept is preferred to the concept of disruption. Such learning processes are primary values to transfer in companies’ digital transformation in order to implement it efficiently and effectively creating new opportunities at an international level. The paper leverages on an explorative research based on the empirical setting of three international Italian manufacturing companies that have experienced challenges of the 2nd, 3rd and are now facing an important digital transformation process in a worldwide landscape. A qualitative constructive multiple case research design is conducted to evaluate the conceptual model and some considerations emerged from the analysis. The paper also benefits from 30 years of experience of one of the Authors as Business Development Director of big multinational companies accompanying many enterprises during their digital transformation. This study presents an interpretative framework that provides an exploration of main heritages coming from the past industrial revolutions according to three aspects: business drivers, supply view and entrepreneurial model. The emerged evidences can be taken as lessons by international manufacturing companies in order to implement digital transformation enhancing their international competitiveness.
Descriptive Complexity, Computational Tractability, and the Logical and Cognitive Foundations of Mathematics
Authors: Pantsar Markus
Published: November 2020

In computational complexity theory, decision problems are divided into complexity classes based on the amount of computational resources it takes for algorithms to solve them. In theoretical computer science, it is commonly accepted that only functions for solving problems in the complexity class P, solvable by a deterministic Turing machine in polynomial time, are considered to be tractable. In cognitive science and philosophy, this tractability result has been used to argue that only functions in P can feasibly work as computational models of human cognitive capacities. One interesting area of computational complexity theory is descriptive complexity, which connects the expressive strength of systems of logic with the computational complexity classes. In descriptive complexity theory, it is established that only first-order (classical) systems are connected to P, or one of its subclasses. Consequently, second-order systems of logic are considered to be computationally intractable, and may therefore seem to be unfit to model human cognitive capacities. This would be problematic when we think of the role of logic as the foundations of mathematics. In order to express many important mathematical concepts and systematically prove theorems involving them, we need to have a system of logic stronger than classical first-order logic. But if such a system is considered to be intractable, it means that the logical foundation of mathematics can be prohibitively complex for human cognition. In this paper I will argue, however, that this problem is the result of an unjustified direct use of computational complexity classes in cognitive modelling. Placing my account in the recent literature on the topic, I argue that the problem can be solved by considering computational complexity for humanly relevant problem solving algorithms and input sizes.
Beans and Melons: Rousseau’s Vegetable Garden
Authors: Brillaud Jérôme
Published: November 2020

This article focuses on a rarely studied aspect of Jean-Jacques Rousseau’s oeuvre: his interest in gardening and more precisely vegetable gardening. Close attention to the text reveals that gardening is part of larger philosophical questions related to private property, luxury, space, education and theatre. Some of Rousseau’s most productive ideas are supported by references to gardening particularly the cultivation of ‘miserable’ beans and ‘prized’ melons. The two plants which were commonly grown in eighteenth-century gardens are at the centre of a philosophical parable inEmile. Beans and melons and their symbolical values fertilise larger questions Rousseau engaged with throughout his life. Although he favoured botany over horticulture, he used kitchen gardens as sites of philosophical experiments.
The direct method of Lyapunov for nonlinear dynamical systems with fractional damping
Authors: Hinze Matthias , Schmidt André , Leine Remco I.
Published: November 2020

In this paper, we introduce a generalization of Lyapunov’s direct method for dynamical systems with fractional damping. Hereto, we embed such systems within the fundamental theory of functional differential equations with infinite delay and use the associated stability concept and known theorems regarding Lyapunov functionals including a generalized invariance principle. The formulation of Lyapunov functionals in the case of fractional damping is derived from a mechanical interpretation of the fractional derivative in infinite state representation. The method is applied on a single degree-of-freedom oscillator first, and the developed Lyapunov functionals are subsequently generalized for the finite-dimensional case. This opens the way to a stability analysis of nonlinear (controlled) systems with fractional damping. An important result of the paper is the solution of a tracking control problem with fractional and nonlinear damping. For this problem, the classical concepts of convergence and incremental stability are generalized to systems with fractional-order derivatives of state variables. The application of the related method is illustrated on a fractionally damped two degree-of-freedom oscillator with regularized Coulomb friction and non-collocated control.
Biliary adverse events in acromegaly during somatostatin receptor ligands: predictors of onset and response to ursodeoxycholic acid treatment
Authors: Prencipe N. , Bona C. , Cuboni D. , Parasiliti-Caprino M. , Berton A. M. , Fenoglio L. M. , Gasco V. , Ghigo E. , Grottoli S.
Published: November 2020

Purpose

Somatostatin receptor ligands (SRL) are the first-line medical treatment for acromegaly. Gallbladder alterations are one of most important SRL side effect, but according to some authors growth hormone hypersecretion itself is a risk factor for gallstones. This single center, longitudinal retrospective study evaluated the incidence and the predictors of biliary adverse events (BAE) in acromegaly during SRL therapy and their response to ursodeoxycholic acid (UDCA).

Methods

91 acromegaly patients with indication to SRL were enrolled. Evaluations of acromegaly activity (GH, IGF-I, IGF-I/ULN) and metabolic profile were collected before starting treatment, yearly during follow-up and at BAE onset. In patients developing BAE we searched for predictors of UDCA effectiveness.

Results

61.5% of patients developed BAE (58.9% cholelithiasis; 41.1% only sludge). IGF-I and IGF-I/ULN proved to be positive predictor of BAE, which occur about 5 years after SRL starting. None of metabolic markers proved to be associated with BAE. Only five patients (5.5%) underwent cholecystectomy for symptomatic cholelithiasis. 71% of patients started UDCA treatment, achieving regression of BAE in 60% of cases (88% in patients developing only sludge and 30% in patients affected by cholelithiasis, p < 0.001). BMI and obesity were negative predictors of UDCA efficacy. In 50% of the subjects BAE resolved after 36 months of therapy with a lower rate if cholelithiasis was present.

Conclusion

Biliary stone disease is a frequent SRL adverse event, although it is often symptomless. Ultrasound follow-up mainly in the first 5 years of therapy, early UDCA starting and proper lifestyle represent a valid strategy in their detection and management.
Explanation by status as empty-base explanation
Authors: Kappes Yannic
Published: November 2020

This paper explores the practice ofexplanation by status, in which a truth with a certain status (i.e. necessary status, essential status, or status as a law) is supposed to be explained by its having that status. It first investigates whether such explanations are possible. Having found existing accounts of the practice wanting, it then argues for a novel account of explanation by status asempty-base explanation. The latter notion captures a certain limiting case of ordinary explanation so that according to the empty-base account, explanation by status can be fruitfully understood as a corresponding limiting case of ordinary explanation. One way in which the empty-base account is argued to be superior to other treatments of explanation by status is that it allows for a principled assessment of the possibility of particular kinds of explanation by status. Thus, one result of the present discussion is that explanation by essential status and status as a law are possible, while explanation by merely necessary status is not.
Mathematizing as a virtuous practice: different narratives and their consequences for mathematics education and society
Authors: Kant Deborah , Sarikaya Deniz
Published: November 2020

There are different narratives on mathematics as part of our world, some of which are more appropriate than others. Such narratives might be of the form ‘Mathematics is useful’, ‘Mathematics is beautiful’, or ‘Mathematicians aim at theorem-credit’. These narratives play a crucial role in mathematics education and in society as they are influencing people’s willingness to engage with the subject or the way they interpret mathematical results in relation to real-world questions; the latter yielding important normative considerations. Our strategy is to frame current narratives of mathematics from a virtue-theoretic perspective. We identify the practice ofmathematizing, put forward by Freudenthal’s ‘Realistic mathematics education’, as virtuous and use it to evaluate different narratives. We show that this can help to render the narratives more adequately, and to provide implications for societal organization.
Tribological Analysis of Contacts Between Glass and Tungsten Carbide Near the Glass Transition Temperature
Authors: Chizhik Petr , Friedrichs Marcel , Dietzel Dirk , Schirmeisen André
Published: November 2020

In recent years, the tribological contact between hard solids and glass at high temperatures has been identified as a crucial aspect in emerging technical applications like e.g., precision glass molding. To optimize such tribological systems, especially, the internal transformations of the glasses need to be considered, since these can determine which kind of energy dissipation channels become relevant, when the temperature of a glass is increasing and approaching the glass transition temperature. Here, we now introduce a new tribometer specifically developed for the analysis of glasses at elevated temperatures. Using this tribometer, we characterize friction of contacts between tungsten carbide (WC) and soda lime glass as a function of temperature, while additionally PMMA was analyzed for comparison. Our experiments reveal different tribological regimes where either simple sliding, surface fracturing, or surface deformation can be identified as relevant interface processes for the tribological behavior.

Graphical Abstract
Mechanisms and capacity of high-pressure soaking after hydraulic fracturing in tight/shale oil reservoirs
Authors: Wang Jing , Liu Hui-Qing , Qian Gen-Bao , Peng Yong-Can
Published: November 2020

Huff-n-puff by water has been conducted to enhance oil recovery after hydraulic fracturing in tight/shale oil reservoirs. However, the mechanisms and capacity are still unclear, which significantly limits the application of this technique. In order to figure out the mechanisms, the whole process of pressurizing, high-pressure soaking, and depressurizing was firstly discussed, and a mechanistic model was established. Subsequently, the simulation model was verified and employed to investigate the significances of high-pressure soaking, the contributions of different mechanisms, and the sensitivity analysis in different scenarios. The results show that high-pressure soaking plays an essential role in oil production by both imbibition and elasticity after hydraulic fracturing. The contribution of imbibition increases as the increase in bottom hole pressure (BHP), interfacial tension, and specific surface area, but slightly decreases as the oil viscosity increases. In addition, it first decreases and then slightly increases with the increase in matrix permeability. The optimal soaking time is linear with the increases of both oil viscosity and BHP and logarithmically declines with the increase in matrix permeability and specific surface area. Moreover, it shows a rising tendency as the interficial tension (IFT) increases. Overall, a general model was achieved to calculate the optimal soaking time.
Performance, Modernity and the Plays of J. M. Synge
Authors: Lecossois Helene
Published: November 2020

Irish Revivalist playwright J. M. Synge is often regarded as a realist. Yet what happens when his work is analysed through wider performance studies and situated alongside less familiar historical contexts? By addressing this question, Hélène Lecossois offers new and valuable perspectives on Synge's plays while at the same time engaging with the complexity of his treatment of a range of performance practices – from keening at rural funerals to the performances of 'native villagers' in the entertainment section of International Exhibitions. What emerges from her study is a dramatist acutely aware of the ability of theatre in performance to counteract relentless forward-moving narratives of modernity. Through detailed, contextualized case studies, the book simultaneously makes meaningful contributions to performance studies and opens up theoretical questions of performance relating to the status of the object on stage, the body on stage and theatrical time.