bluuebunny/crossref_metadata_2025 huggingface dataset:
Risk factors for vascular dementia
Authors: Ivanova L. A.
Published: July 2023

Background. An increase in the number of older people with cognitive disorders, including dementia, is expected.The aim. To study the risk factors for vascular dementia.Material and methods. 39 patients with vascular dementia (ICD-10 diagnosis code F01) were examined. The comparison group consisted of 167 people. According to the MMSE (Mini Mental State Examination) scale, moderate dementia was detected in 56.4 % of cases, severe – in 43.6 %; in the comparison group, 94 % had mild and 6 % – moderate cognitive impairment.Results. In the vascular dementia group, the following risk factors were registered significantly more often: ischemic heart disease – at the age of 70–79 years (57.1 %; p = 0.000) and in the group as a whole (56.4 %; p = 0.000); diabetes mellitus – at the age of 60–69 years (100 %; p = 0.005); arterial hypertension – at the age of 70–79 years (100 %; p = 0.000) and in the group as a whole (87.2 %; p = 0.000). In the comparison group, the frequency of body mass index over 25 was significantly higher at the age of 70–79 years (60 %; p = 0.000), 80 years and older (64.3 %; p = 0.037) and in the group as a whole (68.9 %; p = 0.000). Among people with moderate cognitive impairment, the following risk factors were significantly more common: coronary heart disease – at the age of 60–69 years (10 %; p = 0.001); diabetes mellitus – at the age of 70–79 years (40 %; p = 0.025) and in the group as a whole (50 %; p = 0.033), the frequency of body mass index over 25 – at the age of 80 years and older (70 %; p = 0.000) and in the group as a whole (100 %; p = 0.000).Conclusion. Risk factors for the development of cognitive disorders (coronary heart disease, hypertension, diabetes mellitus, overweight) are potentially reversible; their timely detection can reduce the development of cognitive disorders and dementia.
Castleman disease. A rare clinical case of retroperitoneal tumor localization in an elderly patient
Authors: Polyanskiy M. B. , Zvyagin I. N. , Petrik V. A. , Temirbulatov M. V.
Published: July 2023

Castleman disease is an extremely rare benign disease of the lymphatic system with an estimated incidence of 1–9 cases per 1,000,000. Its etiology remains unknown; interleukin 6 (IL-6) plays an important role in pathogenesis. Castleman disease has two clinical forms: localized (up to 90 % of cases) with a favorable prognosis, treated predominantly by surgical method; generalized (up to 10 % of cases) with less favorable prognosis, treated by pharmacological therapy. The diagnosis is rarely established at the preoperative stage.The aim. To present a clinical case of diagnosis and treatment of Castleman tumor of a rare topical localization.Results. A 66-year-old patient was admitted at the Abdominal Oncology Department of the G.E. Ostroverkhov Kursk Oncology Scientific and Clinical Center.Diagnosis: Retroperitoneal mass on the right found at the preventive examination; no peripheral lymphadenopathy was detected on ultrasound and computed tomography (CT). After the examination, a preliminary diagnosis was made: Gastrointestinal stromal tumor (GIST) of the small intestine mesentery.  Based on the results of the case conference, the decision was taken to perform a surgery – laparoscopic removal of the tumor under endotracheal anesthesia. For surgical approach, a fan-shaped arrangement of ports was chosen. The surgery had no complications. Intraoperative blood loss was 50.0 ml. The total operating time was 98 minutes.According to the results of the histological study, the following diagnosis was made: Castleman disease, unicentric form, hyaline-vascular variant. En bloc surgery is the standard method for the treatment of localized forms of the Castleman disease. In all cases, long-term follow-up shows a long relapse-free period in almost all patients.During follow-up examinations (ultrasound of the abdominal cavity and retroperitoneal space, CT of the abdominal cavity with contrast enhancement, CT of the chest), no disease recurrence was detected during the year of observation.Castleman disease is a rare non-clonal lymphoproliferative disease of unknown etiology. A rare case of its retroperitoneal localization indicates that in cases with an uncertain nature of the peritoneal mass, Castleman disease should be included in the differential diagnostic search.
Case report of sclerochoroidal calcification
Authors: Chuprov A. D. , Sinkova V. I. , Subkhankulova A. R. , Baryshnikov I. A.
Published: July 2023

Background. Sclerochoroidal calcification is an idiopathic rare benign lesion of the sclera or choroid characterized by histological deposition of calcium pyrophosphate. Taking into consideration its similar clinical manifestations with other diseases of the sclera, the most dangerous of which are malignant, timely verification of the diagnosis with the appointment of a further observation period is important.The aim. The description of a clinical case of sclerochoroidal calcification to improve the efficiency of disease detection through the use of multimodal diagnostics.Material and methods. A 62-year-old patient with complaints of “bright flashes” in her left eye for the past few months, who underwent a standard complex of ophthalmological examinations, supplemented according to indications by optical coherence tomography of peripapillary nerve fibers, macular zone, B-scan, Dopplerography in color Doppler mapping mode. Auxiliary diagnostic methods were magnetic resonance imaging of the orbits and extraocular muscles, computed tomography of the orbits and a biochemical blood test.Results. Considering the anamnesis, the absence of progression of complaints, the data of instrumental diagnostic methods, the absence of pathological blood flow in the area of both eyes formations, the correct diagnosis is most likely to be sclerochoroidal calcification of both eyes, despite the difficulties of the diagnostic process, which consisted in the absence of visualization of foci during ophthalmoscopy. Conclusion. Sclerochoroidal calcification is of interest to practicing ophthalmologists due to the difficulties of diagnostic search and differential diagnosis with malignant neoplasms. Modern medicine has a sufficient set of instrumental and laboratory research methods for making an accurate diagnosis.
Occlusion of rectal arteries in the treatment of recurrent hemorrhoidal disease after transanal surgical interventions
Authors: Zakharchenko A. A. , Litvinyuk N. V. , Polezhaev L. A. , Protopopov A. V. , Vinnik Yu. S. , Danilova A. V.
Published: July 2023

The article presents data on variant X-ray anatomy of the superior rectal artery and types of arterial architectonics of the rectum. The causes of recurrent hemorrhoidal disease after traditional transanal surgical interventions are highlighted. The possibilities of endovascular occlusion of rectal arteries in the treatment of relapses of chronic hemorrhoids are shown. Its technical variants are given depending on the number of hemorrhoidal arteries and types of arterial architectonics of the rectum.Over a 2-year period, clinical results of endovascular occlusion of hemorrhoidal arteries were evaluated in 11 patients with relapse of the disease after various transanal interventions: after latex ligation of internal hemorrhoids – in 5, transanal desarterization of internal hemorrhoids with mucopexia – in 4, hemorrhoidectomy – in 2. The average age of patients was 44.2 ± 12.5 years. Men – 5, women – 6. Superselective occlusion of the target hemorrhoidal branches of the upper rectal artery was performed with EmboGold (Merit Medical) microparticles, 500–700/300–500 mkm in size. Immediate results: cessation of bleeding on the first day – in 4 patients, after 3 days – in 5, after 7 days – in 2. Terms of hospitalization – 1 day, disability – 4.3 ± 0.7 days. Long-term results (from 1 to 2 years) were observed in all 11 patients. The course is relapse-free.As an illustration, a clinical case is presented – successful treatment of a patient with recurrent hemorrhoidal disease by endovascular occlusion of hemorrhoidal arteries after five traditional transanal surgical interventions: sclerosing, ligation, dearterization of internal hemorrhoids, dearterization of internal hemorrhoids with mucopexia, removal of external hemorrhoids. Within 3 months after endovascular occlusion – complete regression of all symptoms of hemorrhoidal disease. According to the questionnaire (after 1 and 2 years) there is no relapse of the disease, the patient is subjectively satisfied with the endovascular treatment.
Outcomes of surgery for high transsphincteric anal fistulas: prospective randomized trial
Authors: Churina Yu. A. , Shlyk D. D. , Rzayev R. T. , Balaban V. V. , Tsarkov P. V.
Published: July 2023

Background. Reliable data on the efficacy and safety of fistulectomy with primary sphincter repair for the treatment of high transsphincteric anal fistulas are deficient.The aim. To compare the efficacy and safety of fistulectomy with advancement muco-muscular flap (F) and fistulectomy with primary sphincter reconstruction (SR) for the treatment of high anorectal fistulas.Methods. A cohort of 92 consecutive patients with transsphincteric anal fistula involving 1/3 to 2/3 of the sphincteric complex were included in prospective randomized study. The primary endpoint was the recurrence rate. The duration of surgery, blood loss, pain intensity, postoperative complications, the duration of wound healing, incontinence, quality of life were registered.Results. Forty-six patients were randomized in each group. A statistically significant difference was obtained for operative time (Group “F” – 45 (20–160) min, Group “SR” – 33 (10–55) min). The blood loss was 3 (1–20) and 2 (1–10) ml in Groups “F” and “SR”, respectively (p = 0.482). The return to work in Groups “SR” and “F” occurred after 7 (2–14) and 8 (4–20) days, respectively (p = 0.005). The pain syndrome was significantly greater in Group “F” (p < 0.05) on days 1 and 7. Recurrence rate was in 23.9 % (11 cases) in Group “F” and in 6.5 % (3 cases) in Group “SR” (p = 0.042). Incontinence was in 7 (15.2 %) people in Group “F”, in 10 patients (21.7 %) – in Group “SR” (p = 0.591). There was no statistically significant difference in postoperative complications.Conclusion. Findings can expand the indications for the treatment of high transsphincteric anorectal fistulas involving from 1/3 to 2/3 of the sphincter complex without statistically significant risk for functional results.
Non-alcoholic fatty liver disease as a risk factor for anemia of chronic inflammation (experimental research)
Authors: Brus T. V. , Vasiliev A. G. , Pyurveev S. S. , Kravtsova A. A. , Veber G. S.
Published: July 2023

The aim of the study. In recent years, non-alcoholic fatty liver disease (NAFLD) has been considered a hepatic manifestation of the metabolic syndrome. The main consequence of NAFLD is chronic hepatic inflammation, which leads to dyslipidemia, inflammation, increased oxidative stress, and endothelial dysfunction. Immune activation in response to interaction with agents of a metabolic nature induces the release of pro-inflammatory cytokines in the liver, which subsequently cause iron сhomeostasis disorder. This leads to a frequent association of NAFLD with anemia of various etiology. In this regard, we considered it important to assess the severity of the systemic inflammatory response in NAFLD in the experiment in order to -diagnose anemia of chronic inflammation.Materials and methods. The study was carried out on 26 male Wistar rats, which were divided into control and experimental groups. In animals of the experimental group, NAFLD was modeled according to the generally accepted method. In order to assess metabolic disorders, we determined the main biochemical parameters, a complete blood count with the calculation of erythrocyte indices, the concentration of the main pro-inflammatory cytokines – interleukin (IL) 1, IL-6. Results. In laboratory rats with NAFLD, a statistically significant increase of intrahepatic enzymes in blood serum was found. The state of the erythrocyte lineage of hematopoiesis in the experimental group progressively worsened and caused the development of anemic syndrome. Synchronously, a statistically significant increase in serum levels of IL-1, IL-6 was recorded, which confirms the correlation of NAFLD with anemia of chronic inflammation.Conclusions. A high concentration of IL-1, IL-6 cytokines in NAFLD inhibits iron absorption in the duodenum, leads to the activation of macrophages, blocking the release of iron processed from aging erythrocytes into plasma. Further study of the mechanisms of anemia in NAFLD provides important therapeutic targets in the treatment of both NAFLD and its comorbidities.
Retrospective analysis and modern spatiotemporal characteristics of tularemia in the territory of the West Kazakhstan and North Kazakhstan regions
Authors: Izbanova U. A. , Lukhnova L. Yu. , Meka-Mechenko T. V. , Maykanov N. S. , Sadovskaya V. P. , Meka-Mechenko V. G. , Yusupov A. A. , Makulova A. B.
Published: July 2023

Rationale. An important task is to monitor the incidence of tularemia among the population of Kazakhstan. Natural foci of this infection occupy large areas. In some regions with large numbers of rodents and ectoparasites and low vaccination coverage, human cases of tularemia have been reported.The aim of the study. To carry out retrospective analysis and to study modern spatiotemporal characteristics of tularemia in the West Kazakhstan and North Kazakhstan regions in order to improve the effectiveness of preventive measures.Materials and methods. In our work, we used public records, the results of an epizootological survey of tularemia natural foci and the official data from the Departments of Sanitary and Epidemiological Control of two regions on the human cases of tularemia in 2000–2021. We used descriptive statistics methods, relative and absolute indicators of the tularemia incidence in the population for the analysis. The phenotypic and genetic properties of the strains isolated in 2000–2021 were studied according to the guidelines.Results. A retrospective analysis of the tularemia incidence among the population of the North Kazakhstan and West Kazakhstan regions showed an improvement in the epidemic situation. Over the past 20 years, 4 human cases of tularemia have been registered in the West Kazakhstan region, while the epizootic potential was quite high; more than 300 strains of the tularemia microbe were isolated during the studied period. In the North Kazakhstan region from 2000 to 2021, 11 human cases of tularemia were registered; when studying rodents, mammals and environmental objects, single positive samples for specific tularemia antibodies and antigens were detected; no strains of tularemia microbe were isolated.Conclusion. An analysis of long-term data on the epizootic and epidemic activity of tularemia natural foci, processed using descriptive statistics and GIS technology, made it possible to identify places of long-term persistence of the tularemia agent in the natural focus of the North Kazakhstan and West Kazakhstan regions and to create an electronic map of the territories endemic for tularemia to determine the scope of preventive measures.
Metabolism effector links in diet-induced and genetically-based obesity: A full-transcriptome study of liver tissue in experimental models in rodents
Authors: Apryatin S. A. , Trusov N. V. , Gmoshinski I. V. , Tutelyan V. A.
Published: July 2023

Background. When developing methods for personalized diet therapy of obesity, an urgent task is to study the molecular genetics features of the obesity pathogenesis using in vivo experimental models in laboratory animals.The aim. To determine metabolism effector links in obesity based on a comparative analysis of full-transcriptome profiles of the liver tissue of mice and rats of various strains.Materials and methods. We carried out a comparative analysis of the changes in liver transcriptome in rats and mice fed with diets of excessive energy value and exerting lipogenic effect. Data of full-transcriptome profiling using DNA microarray technology have been presented previously in 8 publications. Results. In three strains of mice treated with a high-carbohydrate high-fat diet (HCHFD), a significant differential expression (DE) of 1849 genes was revealed, of which 74 genes responded jointly in at least two groups of animals. In Wistar and Zuckerfa rats, 2109 genes responded to the consumption of HCHFD, of which 242 genes responded jointly in two groups of animals. For rodents different in genetic predisposition to the development of diet-induced obesity, the groups of genes that responded with the opposite sign of DE (depending on the genotype) in reaction to the consumption of HCHFD were identified. Bioinformatical analysis allowed establishing the presence of 43 metabolic pathways, which are targeted for the applied experimental diets exposure, in rats and 77 pathways – in mice. Four of these pathways – the pathway of retinoid metabolism, PPAR signaling pathway associated with it the previous one, xenobiotics metabolism and drugs metabolism mediated by cytochrome P450 system – responded in all groups of animals (except for female mice). The importance of the expression of Tat gene encoding tyrosine aminotransferase in the modulation of biogenic amines synthesis in diet-induced obesity was shown, which may represent a new neurometabolic regulatory function of the liver in response to the consumption of high-calorie diets. Conclusion. The analysis of the results of full-transcriptome studies showed that within each studied species (Rattus rattus and Mus domesticus) and animal sex, a number of genetic variants with a greater or lesser predisposition to the development of diet-induced obesity phenotype can be identified; and at the same time, within these variants, there is a largely similar pattern in the response of metabolism effector links to hypercaloric dietary intake. This pattern creates new prospects for translating the results of transcriptomic and metabolomic studies of laboratory animals into clinical practice in order to substantiate new approaches to personalized diet therapy of alimentary dependent diseases in patients with different genetic predisposition to obesity.
HPV-associated cervical cancer: Current status and prospects
Authors: Kravtsova E. A. , Tsyganov M. M. , Litviakov N. V. , Ibragimova M. K.
Published: July 2023

Every year, 570,000 new cases of cervical cancer (CC) are diagnosed in the world, and 311,000 people die from this disease. CC is the fourth most common type of cancer and therefore the fourth leading cause of cancer death in women worldwide. Numerous data on the occurrence and development of cervical cancer indicate an association in most cases (up to 90 %) with human papillomaviruses (HPV) of high carcinogenic risk (HCR).CC prevention strategies are based on screening, and deaths from this oncopathology can be prevented through vaccination and treatment with early detection of the disease.In this review, much attention is paid to current issues of detection and prevention of HPV-associated pathologies, and cervical cancer in particular, aiming to summarize and analyze the latest international literature data on this issue. As a result of this study, it was shown that for countries implementing the National program of vaccination against HPV of high carcinogenic risk, a decrease in the incidence of both cervical pathologies of varying severity and other cancers associated with the HPV carriage was registered.While effective implementation of actual experience and future advances in human papillomavirus vaccine prophylaxis may make it possible for all countries to move to the high levels of vaccination coverage required to eliminate HPV-associated pathologies, the results also suggest that the path to complete cervical cancer elimination as a global public health problem can be extremely difficult due to a number of existing limitations.
Markers of Th1 polarized Th17 cells (literature review)
Authors: Kuklina E. M. , Glebezdina N. S.
Published: July 2023

T helpers (Th) producing IL-17 (Th17) have high plasticity and under the influence of external conditions are able to redifferentiate into cells with a different phenotype, primarily in Th1-lymphocytes, forming a population that combines the characteristics of both Th17 and Th1 and has a high pro-inflammatory potential, as well as a unique ability to overcome histohematic barriers. These cells are currently assigned a key role in the pathogenesis of many inflammatory diseases, including autoimmune ones: they account for up to half of the lymphocytes present in infiltrates of inflamed tissues. The paper discusses the reasons for the increased plasticity of Th17 cells in comparison with the main T helper populations (Th1 and Th2) and considers in detail the mechanisms of formation of IFNγ producing Th17, taking into account not only the redifferentiation of mature Th17, but also possible alternative pathways, in particular, Th1 cell redifferentiation or naive CD4+T lymphocytes direct differentiation into cells with an intermediate Th1/Th17 phenotype. The main inducers of differentiation of IFNγ producing Th17 cells and the reversibility of this process are also discussed. Particular attention is paid to the methods for identifying Th1 polarized Th17 cells: this population is heterogeneous, and its size significantly depends on the type of markers used to characterize these cells – Th1/Th17-associated transcription factors, key cytokines, as well as chemokine receptors and other membrane molecules. As a result, the data in the works on this problem are poorly comparable with each other. The unification of approaches to identifying a population of Th1 like Th17 cells will solve this problem and make it possible to use an assessment of the size and activity of such a population as diagnostic or prognostic markers.
Clinical symptoms and ECG data in women with acute coronary syndrome
Authors: Sumin A. N. , Vakhrushev A. K. , Shcheglova A. V.
Published: July 2023

Background. There are many differences in chest pain symptoms between men and women in terms of location, nature, and additional symptoms. The issue of describing the differences in chest pain in men and women with acute coronary syndrome (ACS), as well as their correlation with changes in the electrocardiogram (ECG) and coronary angiography (CAG) remains relevant.Methods. The study included 588 patients of the cardiology department of the Novokuznetsk City Clinical Hospital No. 1 from 2013 to 2017 with a diagnosis of ACS. Depending on the gender, the subjects were divided into two groups: Group I – 330 men; Group II – 258 women.Results. ACS with ST elevation was more common in men (45.8 %) than in women (33.3 %; p = 0.002). There were no pathological ECG changes in women in 58.1 % of cases, in men – in 45.5 % (p < 0.001). ECG type Q/ST elevation was detected more often in men (45.8 %) than in women (33.3 %; p = 0.002). The absence of coronary artery lesions was observed in 27.9 % of men and 44.2 % of women (p < 0.001). Hemodynamically significant coronary artery stenosis was more common in men (57.6 %) than in women (38.7 %; p < 0.001). In a typical angina clinic, hemodynamically significant coronary artery disease in patients with Q/without ST elevation ACS was detected in 40.2 % of men and in 58.5 % of women (p = 0.002). In the atypical angina clinic, hemodynamically significant lesions of coronary artery were more common in men (40.6 %) than in women (34.1 %; p = 0.02).Conclusion. In women atypical chest pains and intact coronary arteries were detected more often than in men, and hemodynamically significant coronary artery stenosis were found less often than in men. In men, a more pronounced pathology of the coronary arteries in ACS was revealed, in women – great difficulties in diagnosing ACS.
A Concept of the Needs of The Ministry’s Internal Policy Agency for the Policy Response to the Formation of BRIN
Authors: Wibowo Willy
Published: July 2023

The current Government policy that integrates all Research and Development Agencies in Ministries and Institutions demands that these agencies must be transformed. To be able to answer various strategic issues and anticipate demands that come from the internal and external environment is the basis for an organization to organize and evaluate internally. Proposed organizational arrangements in this case must have a clear basis and contain analysis of the various aspects needed. The purpose of this scientific work is to provide a concept for transforming a research and development Agency into an internal Policy Agency to avoid duplication of duties and functions in existing Research Agencies. This study uses the policy review type method which is focused on reviewing documents. The need for an Internal Policy Agency at the Ministries/Agencies level is currently very urgent because of the diverse and complex fields of work and to produce quality policies and can be measured by the Policy Quality Index. There are several suggestions for Ministries/Institutions that will form an Internal Policy Agency, among others, transformation must be based on evidence-based needs.
Trabajo matemático de estudiantes de secundaria en tareas sobre tasa de variación con el uso de GeoGebra
Authors: Ticse Aucahuasi Marco Antonio , Flores Salazar Jesús Victoria , Vivas Pachas Jorge Luis
Published: July 2023

A partir de la mirada vigilante de la Didáctica de la Matemática en la enseñanza del Cálculo, buscamos caracterizar el conocimiento y trabajo matemático emergente de estudiantes de educación secundaria cuando resuelven tareas sobre la tasa de variación mediado por GeoGebra. Desde la teoría de Espacio de trabajo matemático, analizamos la producción matemática de estudiantes chilenos (16-17 años) y concluimos que dar sentido a la tasa de variación parte de un trabajo basado en procesos algorítmicos y un enfoque de interpretación/experimentación a la idea de variación y cambio subrayando el rol del artefacto, siendo singular establecer procesos de prueba y demostración.
Função afim e suas características abordadas por meio do cenário animado Abelha no Geogebra
Authors: Bueno Adrieli , Basniak Maria Ivete , García Cuéllar Daysi Julissa
Published: July 2023

Este artigo teórico objetiva discutir características da função afim por meio da construção de um cenário animado elaborado no GeoGebra a partir dos elementos da Aproximação Instrumental (AI). A AI é usada para revelar o potencial da tecnologia digital para a aprendizagem de matemática. Os resultados indicam que, através de técnicas empregadas e dos invariantes operatórios dos esquemas identificados, é possível vislumbrar características da função afim ao utilizar esses elementos matemáticos para construir o cenário animado. Assim, elementos da AI auxiliaram a evidenciar características da função afim ao construir o cenário animado Abelha no GeoGebra
O sentido espacial na creche: a torre dos cubos
Authors: Pinto Hélia , Dias Isabel Simões , Gaspar Duarte Nicole
Published: July 2023

Este estudo visa perceber como se desenvolveu o sentido espacial num momento de brincadeira livre na creche entre 11 crianças (12/24 meses) e um adulto, no episódio denominado torre dos cubos. Adotando o paradigma interpretativo, recorreu-se à   observação participante para aceder aos dados. Os resultados revelam comportamentos das crianças e do adulto (e.g., as crianças aproximam-se e afastam-se do local da construção; o adulto modela comportamentos) que nos levam a inferir que a criança desenvolve o sentido espacial de forma intuitiva e espontânea, na interação com objetos, com pares e com adulto(s) responsivo(s).
TERAPIA DO COÁGULO SANGUÍNEO AUTÓLOGO NA CICATRIZAÇÃO DE LESÕES: REVISÃO DE ESCOPO
Authors: Costa Rodrigues Grasiele , Lucca de Camargo Lucio Rodrigo , Souza Elisangela , Bulegon Mello Deborah , Iribarrem Ness Mariana , Czadotz Gisele Cristiane , BARCELLOS TEIXEIRA MACEDO ANDREIA
Published: July 2023

Objetivo: Mapear e sumarizar evidências científicas sobre a terapia do coágulo sanguíneo autólogo na cicatrização das lesões. Método: Trata-se de uma revisão de escopo construída em cinco etapas, realizada nas bases/motores de busca Biblioteca Virtual em Saúde (BVS), PubMed, Google Acadêmico, Biblioteca Scientific Electronic Library Online (SCIELO) e no Portal de Teses e Dissertações da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Os descritores controlados foram “cicatrização” e “ferimentos e lesões” e o não controlado Terapia do Coágulo Sanguíneo Autólogo”, com suas derivações em inglês e espanhol. Foram incluídos artigos publicados nos últimos 10 anos, e excluídos os duplicados ou que não estivessem disponíveis na íntegra. Para a extração foi construído um quadro sinóptico e os dados foram analisados de forma descritiva. Resultados: Foram identificadas 246 publicações e a amostra final foi composta por 16 publicações. O ano de 2022 foi o que apresentou maior número de publicações (5;33,4%), 15(93,7%) estudos estavam em inglês e 12(75,0%) em revistas dos Estados Unidos. Não foram localizados estudos no Brasil sobre o tema. Verificou-se que 11(68,7%) estudos avaliaram o efeito da terapia, dos quais 6(37,5%) tiveram delineamento quase-experimental, três (18,7%) foram estudo de caso e dois (12,5%) estudo de série de casos.  Conclusões: O artigo atingiu os objetivos ao mapear as evidências científicas sobre a temática, demostrando que a terapia possui boa efetividade no tratamento de lesões por pressão. Contudo, há limitações pela falta de pesquisas com métodos com maior nível de evidência e com amostras maiores.
PROTOCOLO DE REVISÃO SISTEMÁTICA SOBRE FATORES DE RISCO PARA LESÃO POR PRESSÃO: RELATO DE EXPERIÊNCIA
Authors: DA PENHA ANA ALINNE GOMES , PIRES DANTAS TAYS , PARENTE SA BARRETO JULIANA ALEXANDRA , BARBOSA BEZERRA TAMIRES , LEITE SAMPAIO LUIS RAFAEL
Published: July 2023

Objetivo: Relatar o processo de construção de um protocolo de revisão sistemática e seu registro na base de dados PROSPERO sobre fatores de risco para lesão por pressão entre pacientes adultos em unidades de terapia intensiva. Método: Trata-se de um relato de experiência, com caráter descritivo e abordagem qualitativa, de enfermeiros pesquisadores da área da estomaterapia sobre a construção de um protocolo de revisão sistemática, cujo objetivo se propõe a identificar e analisar os fatores de risco para lesão por pressão entre pacientes adultos em unidades de terapia intensiva. A experiência foi apresentada em dois eixos temáticos: 1) Elaboração do protocolo de revisão sistemática; 2) Registro na base de dados online PROSPERO. Resultados: O protocolo contou com a composição das seguintes etapas: elaboração da questão de pesquisa, busca de publicações relevantes, seleção dos estudos encontrados, extração de dados, análise e síntese das evidências. No que se refere ao registro, este foi realizado durante a submissão na PROSPERO de acordo com as informações solicitadas referentes aos 38 itens do protocolo de estudo de revisão sistemática. Considerações finais: O relato permitiu apresentar as etapas seguidas para o desevolvimento do protocolo de revisão sistemática e seu registro na PROSPERO, contribuindo para subsidiar as etapas a serem seguidas pelos pesquisadores no desenvolvimento de estudos desse cunho na área de enfermagem.
TOPOGRAPHY AND DEFENSIVE BUILDINGS OF KOTELEVSKY HILLFORT
Authors:   Сумський державний педагогічний університет імені А. С. Макаренка, Коротя Олексій ,   Комунальна установа «Історико-культурний заповідник «Більськ» Полтавської обласної ради
Published: July 2023

The article is devoted to the results of archaeological explorations on the territory of the Kotelevsky hillfort, which is located to the northeast of the Bilsky hillfort. Today, the Kotelevsky hillfort is one of the controversial archaeological sites, which contains materials from the Bronze Age and the final stage of the Early Iron Age. The peculiarity of this archaeological site is that it is located on the left bank of the Vorskla river, which is unique for the Early Iron Age settlements of this region. Earlier, its belonging to the Scythian period was doubted. In addition, there are no finds from the VI-IV centuries BC on the hillfort, and it was at this time that all the Scythian hillforts known today were built, which also complicates the dating of defensive structures in particular. Today, the question of the origin of the fortifications of the hillfort and their connection with the archaeological cultures discovered during the excavations of recent years is relevant. Two important aspects were highlighted in the work, namely, the analysis of the paleorelief and defensive structures of the hillfort, the solution of which will allow us to answer the time of its origin and the specifics of the location of this monument.
How and why can explicit instruction about L1 reduce the negative effects of crosslinguistic influence? Evidence from accuracy and reaction time signatures in L1 comprehension
Authors: McManus Kevin
Published: July 2023

This study revisits and extends McManus and Marsden (2019a) to better understand how and why providing additional explicit information (EI) about learners’ first language (L1) alongside EI and comprehension practice in the second language (L2) improved the accuracy, speed, and stability of L2 comprehension of the French Imparfait, a functionally complex and late-acquired target feature. Building on previous L2 research that has provided instruction about L1 without analyzing L1 knowledge/use, the current study examines learners’ item-by-item comprehension of L1 sentences that was completed during the L2 instruction to better understand the learning mechanisms at play in McManus and Marsden’s (2019a) findings. Two groups of English-speaking learners (L2+L1, L2+L1prac; N = 36) received the same EI about aspect in French, followed by comprehension practice of French and English sentences. The L2+L1 group received additional EI about aspect in English. Results showed no impact of the instruction on L1 accuracy in either group, but the speed of L1 comprehension changed over time in the L2+L1 group. It is argued that the L2+L1 instruction directed attention to and clarified crosslinguistic differences in how L2 and L1 express the same meanings, which rendered the L2 practice more effective for noticing Imparfait and developing appropriate strategies for processing L2 forms. Implications for theory-building and instructional design are discussed.
The reciprocal relationship between well-being comparisons and anxiety symptoms in the context of metacognitions and external control beliefs
Authors: Schlechter Pascal , Hellmann Jens H. , Morina Nexhmedin
Published: July 2023

Background: Anxiety is a prevalent mental health condition characterized by worry, fear, and avoidance behavior. Comparisons of one’s own well-being to different aversive standards may contribute to the development and maintenance of anxiety symptoms. Objectives: Accordingly, we investigated whether aversive well-being comparisons predict anxiety symptoms. We included metacognitive beliefs about worrying and external control beliefs as additional predictors. Methods: In total, 922 participants completed measures of anxiety, metacognitions about the uncontrollability of worries, external control beliefs and the Comparison Standards Scale for Well-being (CSS-W) at two timepoints, with a three-month interval between them. The CSS-W assesses the frequency, perceived discrepancy, and affective impact of social, temporal, counterfactual, and criteria-based comparisons. Results: When autoregressive effects were controlled, aversive comparison frequency, comparison affective impact, and uncontrollability of worries at the first timepoint predicted subsequent anxiety symptoms. Furthermore, well-being comparison frequency and discrepancy at the second timepoint were predicted by baseline anxiety symptoms. Conclusions: Well-being comparisons emerged as robust predictor of anxiety symptoms beyond baseline anxiety and established risk factors. Anxiety symptoms contribute distinct variance to the comparison process, pointing to a vicious cycle of symptom escalation. These findings have significant implications for research investigating the intricate interplay between well-being comparisons and anxiety.
DEVELOPMENT OF THE SOUTH-BASHKORTOSTAN AGGLOMERATION: PROBLEMS AND PROSPECTS
Authors: Mukhametova Aigul
Published: July 2023

Introduction. Currently, there is an increase in interregional disproportions and inequalities in regional development effecting increasing gaps between the maximum and minimum values of socio-economic indicators in Russian regions. Regional development requires to determine the territories that, due to the attraction of factors of production and the accumulation of resources, will become points of growth. Thus, according to some authors, agglomerations can become such a point of growth for regional development. This article is devoted to the problems and prospects of regional development of the South Bashkortostan agglomeration. Methodology. The author analyzed the socio-economic development of the agglomeration using the methods of economic, statistical analysis, systematization, synthesis, forecasting and scenarios. Results. Based on the analysis, the author identifi ed modern problems of agglomeration development, such as a decrease in the population of the region, due to natural and migration decline in the population, uneven socio-economic development of the municipalities that are part of the South Bashkortostan agglomeration, a decrease in the investment attractiveness of the territory, an increase in the budget defi cit of individual municipal formations. Conclusions. The results of the study can be applied in the development of strategic documents on the socio-economic development and management mechanism of the South Bashkortostan agglomeration.
Computer Vision and Machine Learning to Quantify Microstructure
Authors: Holm Elizabeth A. , Cohn Ryan , Gao Nan , Kitahara Andrew R. , Lei Bo , Yarasi Srujana Rao , Matson Thomas P.
Published: July 2023

Vision-based machine learning systems for microstructural characterization and analysis are being successfully used for image classification, semantic and instance segmentation, and object detection, leading to accurate, autonomous, objective, and repeatable results.
Using Conventional Light Microscopy to Reveal the Hierarchical Microstructure of 3D-Printed Metal Parts
Authors: Tonelli Lavinia
Published: July 2023

This entry won the prestigious Jacquet-Lucas Award for Best in Show in the 2020 International Metallographic Contest. In the research discussed in this article, light microscopy was applied to a Co28Cr6Mo alloy for a biomedical application processed by laser bed powder fusion (LPBF) additive manufacturing.
SERİ ÜRETİM HATLARINDA GÜVENİLİRLİK ANALİZİ İLE DURUMSAL FARKINDALIĞIN ARTIRILMASI
Authors: ÖZ Diler , EDİZKAN Rifat , YAZİCİ Ahmet
Published: July 2023

Bir işletmedeki üretim hatlarının performansı ve kapasitesi planlanmamış makine duruşları en aza indirilerek artırılabilir. Bu duruşların sıklıkla meydana geldiği üretim hatları için arızalar analiz edilmeli ve duruşlara neden olan sorunları azaltmak için bakım planlanması yapılmalıdır. Bu çalışmada, Minyatür Devre Kesici üretim hattında seri olarak çalışan makinelerin bakım planlaması için güvenilirlik analizine dayalı durumsal farkındalık modeli önerilmiştir. Durumsal farkındalık, üretim hattında plansız duruş hatalarını azaltmak için doğru kararların alınmasında ve planlamaların yapılmasında kullanılabilecek önemli bilgiler sağlayacaktır. Önerilen model, üretim hattında operatör, bakımcı ve yönetici düzeyinde durumsal farkındalığı artıracaktır. Güvenilirlik analiz için makinelerin duruş verileri Üretim Yönetim Sistemi üzerinden toplanmıştır. Güvenilirlik analizinde arızalanma süresi ve onarım süresi değerleri kullanılmıştır. Analiz yapılan zaman aralığındaki verilerden gelecekte darboğaz oluşturabilecek arızalar belirlenmiştir. Bakım planlamasında bu arızalara öncelik verilmelidir.
GDSC VERİLERİNİ KULLANARAK YAPAY ÖĞRENME YÖNTEMLERİ İLE AKCİĞER KANSERİ İÇİN HEDEF İLAÇ VE YOLAK TAHMİNİ
Authors: TERCAN Abdullah , ÖZCAN Gıyasettin
Published: July 2023

Bu çalışmada literatürde yer alan ve uluslararası alanda öneme sahip olan GDSC veri kümesinde yer alan akciğer kanseri verileri toplanmış, ve bu veriler üzerinde yapay öğrenme yöntemleri kullanarak tahmin yapmak hedeflenmiştir. Bu amaçla ilaç dozunun yarılanma süresine bağlı hedef ilaç ve hedef yolak tahminleri yapılmıştır. Elde edilen bu iki tahminin yine literatürde yer alan CTDBase isimli bir veri kümesinden hastalık tahmini için kullanılması amaçlanmıştır. Böylece ilaçların doz kullanım bilgilerinin hangi hastalıkla ilişkili olabileceği sayısal verilerden tahmin edilmeye çalışılmıştır. Yapılan tahmin işlemi makine öğrenmesi algoritmaları kullanılarak yapılmıştır. Bu süreçte Python programlama dili ile kodlama yapılmış ve bu dilin makine öğrenmesi araçlarından faydalanılmıştır. Elde edilen sonuçlara göre Neighborhood Components Analysis temelini kullanan kNN algoritmasının GDSC veri kümesinde verimli tahmin performansına ulaştığı sonucuna varılmıştır. Bu nedenle kNN algoritması farklı k değerleri ile daha detaylı analiz edilmiştir. Elde edilen tahmin sonuçları % 70 - % 90 aralığında bulunmuştur. Bu sonuçlar makine öğrenmesi algoritmalarının kanser ilaç verilerine ait bilinmeyen anlamlı örüntüleri ortaya çıkarma potansiyeli olduğunu göstermektedir.
GMAW KAYNAK YÖNTEMİ İLE BİRLEŞTİRİLMİŞ FARKLI PASLANMAZ ÇELİKLERİN MEKANİK VE MİKROYAPI ÖZELLİKLERİNE KULLANILAN İLAVE TELİN ETKİSİNİN İNCELENMESİ
Authors: YÜRÜK Ali
Published: July 2023

Ferritik ve östenitik paslanmaz çelikler birçok endüstriyel alanda bir arada kullanılmaktadır. Bu durumda bu iki paslanmaz çelik türünün birleştirilmesini zorunu hale getirmektedir. Bugüne kadar yapılan çalışmalar incelendiğinde genelde kaynak akımı, kaynak hızı vb parametreler üzerinde yoğunlaşıldığı görülürken kaynak telinin birleştirmeler üzerindeki etkisi araştıran çok az çalışmaya rastlanmıştır. Bu nedenle bu çalışmada kaynak ilave telinin birleştirmenin mekanik ve mikroyapısına etkilerini incelemek için AISI 304 östenitik paslanmaz çelik ile AISI 430 ferritik paslanmaz çelik farklı kaynak hızlarında GMAW kaynak yöntemi ile birleştirilmiştir. Daha sonra yapılan kaynaklı birleştirmenin makro ve mikroyapı özelliklerini tespit etmek içinde mikroyapı çalışmaları gerçekleştirilirken mekanik özelliklerini belirlemek içinde sertlik, çekme testleri uygulanmıştır. Gerçekleştirilen çalışmalar sonucunda kaynak metalinin mikroyapısının martenzit+ östenit + ferritten oluştuğu görülmüştür. Sertlik ölçüm sonuçlarında ise en sert bölgenin kaynak metali olduğu belirlenirken 308L kaynak teli ile birleştirilen numunelerin sertlik ölçümleri 309LSi kaynak teli ile birleştirilen numunelere oranla daha yüksek çıkmıştır. Kaynak tellerinin kaynak metaline Mn ve Cr gibi dayanım artırıcı elementler katması sebebiyle üretilen tüm kaynaklı birleştirmelerin çekme dayanımı AISI 430 ana malzemeden daha yüksek ölçülmüştür.
THE INFLUENCE OF TEACHER PERCEPTIONS OF THE NATIONAL ASSESSMENT AND UTILIZATION OF INSTRUCTIONAL MEDIA ON THE QUALITY OF HIGH SCHOOL LEARNING
Authors: Wisnugroho Arfianto , Haryanto NFn
Published: July 2023

Changes to the assessment system with the abolition of the UN (National Examination) and the implementation of the AN (National Assessment) elicited mixed reactions from teachers. AN is not a determinant of graduation but a school quality assessment program. It is necessary to study teachers' perceptions of AN and how these perceptions influence teachers' use of supportive learning media in improving the quality of learning. This study aims to determine the effect of teachers' perceptions of AN and instructional media on the quality of learning in senior high schools in South Aceh District. Quantitative research with a survey research design was carried out using a questionnaire sheet as a research instrument. Data analysis used inferential statistics, namely, linear regression and descriptive statistics, namely, the ideal assessment category. The results show that there is a significant influence between teachers' perceptions of AN and the use of instructional media on the quality of learning. Abstrak.Perubahan sistem asesmen dengan penghapusan UN (Ujian Nasional) dan penerapan AN (Asesmen Nasional) menimbulkan reaksi yang beragam dari kalangan guru. AN bukanlah penentu kelulusan namun program penilaian mutu sekolah. Kajian tentang persepsi guru terhadap AN dan bagaimana persepsi tersebut memengaruhi guru memanfaatkan media pembelajaran yang mendukung dalam peningkatan kualitas pembelajaran perlu dilakukan. Penelitian ini bertujuan untuk menganalisis pengaruh persepsi guru terhadap AN dan pemanfaatan media pembelajaran terhadap kualitas pembelajaran SMA di Kabupaten Aceh Selatan. Penelitian kuantitatif dengan desain penelitian survei dilakukan dengan menggunakan lembar angket sebagai instrumen penelitian. Analisis data menggunakan statistik inferensial yaitu regresi linear dan statistik deskriptif yaitu kategori penilaian ideal. Hasil penelitian menunjukkan bahwa terdapat pengaruh yang signifikan antara persepsi guru terhadap AN dan pemanfaatan media pembelajaran terhadap kualitas pembelajaran.
A 14-Year Longitudinal Analysis of Healthcare Expenditure on Dementia and Related Factors (DEMENCOST Study)
Authors: Inoriza José M. , Carreras Marc , Coderch Jordi , Turro-Garriga Oriol , Sáez Marc , Garre-Olmo Josep
Published: July 2023

Background:

The large number of dementia cases produces a great pressure on health and social care services, which requires efficient planning to meet the needs of patients through infrastructure, equipment, and financial, technical, and personal resources adjusted to their demands. Dementia analysis requires studies with a very precise patient characterization of both the disease and comorbidities present, and long-term follow-up of patients in clinical aspects and patterns of resource utilization and costs generated.

Objective:

To describe and quantify direct healthcare expenditure and its evolution from three years before and up to ten years after the diagnosis of dementia, compared to a matched group without dementia.

Methods:

Retrospective cohort design with follow-up from 6 to 14 years. We studied 996 people with dementia (PwD) and 2,998 controls matched for age, sex, and comorbidity. This paper adopts the provider’s perspective as the perspective of analysis and refers to the costs actually incurred in providing the services. Aggregate costs and components per patient per year were calculated and modelled.

Results:

Total health expenditure increases in PwD from the year of diagnosis and in each of the following 7 years, but not thereafter. Health status and mortality are factors explaining the evolution of direct costs. Dementia alone is not a statistically significant factor in explaining differences between groups.

Conclusion:

The incremental direct cost of dementia may not be as high or as long as studies with relatively short follow-up suggest. Dementia would have an impact on increasing disease burden and mortality.