bluuebunny/crossref_metadata_2025 huggingface dataset:
Effectiveness of Tuina manipulation in patients with knee osteoarthritis: study protocol for a randomized controlled trial
Authors: Lv Zhizhen , Zhu Qingguang , Guo Guangxin , Sun Wuquan , Cheng Yanbin , Kong Lingjun , Fang Min , Wu Zhiwei , Xu Shanda , Zhou Xin , Zhang Shuaipan , Yao Chongjie
Published: April 2020

Background: Knee osteoarthritis (KOA) is a common disabling musculoskeletal disorder. Previous studies showed that Tuina manipulation and health care education were effective treatments for patients with KOA. However, there is no evidence to support the use of one intervention rather than another. The purpose of this study is to evaluate the effectiveness of Tuina manipulation and health care education in the management of pain and dysfunction in patients with KOA.Methods/Design: This study is a single center, two-arm, open-label RCT. A total of 150 eligible KOA patients will be randomly assigned to the Tuina manipulation group or the health education group in a 1:1 ratio. Patients in the Tuina manipulation group receives a 30-minute 2-step treatment plan, including pain point assessment and manual therapy, which are performed 12 times in 4 weeks. The health education group conducts 45 minutes of lectures and discussions each time, three times a week for four weeks. The primary outcome is the Knee Injury and Osteoarthritis Outcome Score (KOOS). Secondary outcomes include the McGill Pain Questionnaire (MPQ) and 36-item Short-Form Health Survey (SF-36). The results of this study will help clarify the value of Tuina manipulation and health education as treatments for KOA and will highlight any differences in treatment outcomes.Discussion: The design and methodology of the trial is rigorous and allows the collection of valuable data to assess the efficacy of a specific Tuina regimen in the treatment of KOA. Therefore, the trial will provide a solid foundation for the future clinical research of KOA as well as the future of Tuina therapy.Trial registration: This trial was registered with Chinese Clinical Trial Registry on 24 February 2020(ChiCTR2000030154), http://www.chictr.org.cn/index.aspx
Development of Life-cycle Detection and Extending Function for Reusing Automotive Lithium-ion Battery – Verified in 52V LiMnNiCoO2 Platform
Authors: Sean Wu-Yang , Pacheco Ana
Published: April 2020

For reusing automotive lithium-ion battery, an in-house battery management system is developed. To overcome the issues of life cycle and capacity of reused battery, an online function of estimating battery’s internal resistance and open-circuit voltage based on adaptive control theory are applied for monitoring life cycle and remained capacity of battery pack simultaneously. Furthermore, ultracapacitor is integrated in management system for sharing peak current to prolong life span of reused battery pack. The discharging ratio of ultracapacitor is adjusted manually under Pulse-Width-Modulation signal in battery management system. In case study in 52V LiMnNiCoO2 platform, results of estimated open-circuit voltage and internal resistances converge into stable values within 600(s). These two parameters provide precise estimation for electrical capacity and life cycle. It also shows constrained voltage drop both in the cases of 25% to 75% of ultracapacitors discharging ratio compared with single battery. Consequently, the Life-cycle detection and extending functions integrated in battery management system as a total solution for reused battery are established and verified.
Brazilian Atlantic forest carbon stocks undergoing active restoration after bauxite mining exploration: an approach based on functional attributes
Authors: Balestrin Diego , Martins Sebastião V , Villa Pedro M
Published: April 2020

Background: Tropical forests are important carbon sinks at the global scale. They are important reservoirs of terrestrial carbon and play a fundamental role in global climate regulation. We evaluated the tree species diversity and dominance patterns in stem and carbon stocks in a Brazilian Atlantic forest restored after bauxite mining exploration in the state of Minas Gerais, south-eastern Brazil.Methods: Aboveground carbon was estimated for a permanent 1-ha forest restored after 14 years, measuring all trees with a circumference at breast height (CBH) ≥ 15 cm, planted during restoration. We studied species richness, community composition and stem- and carbon-dominant species based on two categorical functional attributes associated with forest regeneration (successional strategy and dispersal syndrome).Results: The restored forest obtained a high carbon accumulation (~58 Mg ha -1 ), between two and three times more than second-growth forests with the same or more time for natural regeneration, when compared with other restored Brazilian seasonal semideciduous Atlantic Forest stands. The restored forest presented a marked local carbon dominance, with ~7.5% of the tree species of the community representing 50% of the total aboveground carbon (AGC). Anemochoric and zoochoric species presented a similar pattern of carbon dominance, while the initial second-growth species presented a higher carbon storage capacity than the pioneer species.Conclusions: Our findings stress the importance of analysing the relative contributions of species, classified by functional attributes and by their dominance, to ecosystem functioning at fine-scale active restoration.
Manifestaciones de conducta disruptiva y comportamiento perturbador en población normal de 4 a 17 años de edad
Authors: Arias Correa Grace , Montoya Roldán Eliana , Gladys Romero Maria
Published: April 2020

El presente articulo presenta resultados de investigación el cual tenía como objetivo identificar casos con alta probabilidad demanifestar conductas externalizantes en la población normal, para ello se realizó una investigación de corte transversal con una muestra de 444 participantes a los cuales se aplicó el instrumento SNAP-IV (Swanson, Nolan & Pelham,1983). Los resultados sugieren: diferencias en la información suministrada por cada una de las fuentes (padres y maestros) y la presencia de conductas con alta probabilidad de riesgo que pueden ser intervenidas en el medio escolar y familiar.
Impact of gender and education on corporate social responsibility: evidence from Taiwan
Authors: Thanh Binh Nguyen T. , Huang Qi-Wen
Published: April 2020

This paper empirically studies the impact of female proportion and the background of the board on corporate social responsibility (CSR) disclosure of Taiwanese listed firms. The different groups of board size are detected by the structural break test, which is used as the threshold for dividing subsamples. The results show that the higher proportion of women and accounting background of board of directors, the more CSR disclosure for firms with more than 11 directors in the board, implying that women and accounting background directors can only promote their compassionate and reciprocal in CSR decision-making in large board firms. Overall, the empirical results poorly support the efficiency hypothesis suggesting that the board of directors is more powerful when it has high gender diversity. This study also confirms that the linear regression method may not be able to fully present the various possible relationships between the variables.
A pedagógusok folyamatos szakmai fejlődését befolyásoló szervezeti tényezők
Authors: Lénárd Sándor , Kovács Ivett , Tóth-Pjeczka Katalin , Urbán Krisztián
Published: April 2020

A pedagógusok folyamatos szakmai fejlődése (FSZF), mint az oktatási rendszer minőségfejlesztésének egyik központi komponense egyéni, szervezeti és rendszerszinten értelmezhető tényezők komplex együttállásából kibontakozó jelenség. E tanulmány a Models of Teacher Learning című kutatás részeként az FSZF szervezeti szintjére vonatkozó nemzetközi és hazai szakirodalmi vizsgálatok összefoglalója. A szakirodalom áttekintését végző munkánk nyomán feltárulnak azok a modellek, összefüggések, tényezők, amelyek az iskolát mint szervezetet, s a benne működő szervezeti folyamatokat a tanárok szakmai fejlődésének és tanulásának személyes szintjére közvetlen vagy közvetett hatást gyakorló kontextusként jelenítik meg. A legfrissebb oktatáskutatásokban előtérbe került a tanárok horizontális, együttműködő tanulása, az informális tanulás, a munkahelyi tanulás, a mentorálás, az önmegújító iskola fogalma és a tanulószervezet koncepciója is. Bemutatjuk a szervezeti kultúra, az iskolai klíma jelentőségét, FSZF-formáló hatásrendszerét, valamint láthatóvá tesszük, hogyan emelkedik ki a szervezetet alakító strukturális és belső, kulturális tényezők sorából a vezetés. Számba vesszük azokat a feltételeket is, amelyek mellett a vezető kulcsszerepet tud betölteni a tanárok szakmai fejlődésének és tanulásának támogatásában.
A pedagógusok folyamatos szakmai fejlődése és tanulása az oktatási rendszer szintjén
Authors: Kopp Erika
Published: April 2020

A tanulmány célja, hogy a pedagógusok, tanárok tanulásának és a pedagógusok folyamatos szakmai fejlődésének rendszerszintű tényezőire vonatkozó fő elméleti kereteket, modelleket összegezze, illetve a rendszerszintre irányuló vizsgálatok és fejlesztések fő irányait áttekintse, módszere a szakirodalmi másodelemzés segítségével. Az áttekintés struktúrája a következő: először összefoglaljuk a szakmai fejlődés rendszerszintjét meghatározó kontextuális tényezőket, majd értelmezzük a szakmai fejlődés és tanulás fogalmát, e fogalmak alakulásának rendszerszintű tényezőit. Ezután áttekintjük azokat az oktatáspolitikai trendeket, melyek a rendszerszintű fejlesztések irányelveinek változásaiban kimutathatók, majd áttérünk a folyamatos szakmai fejlődés eredményességének rendszerszintű kérdéseinek vizsgálatára. Végül összefoglaljuk azokat az általános sajátosságokat, amelyek egy oktatási rendszer szintjén befolyásolhatják a pedagógusok folyamatos szakmai fejlődését.
Eredményesség és szakmai fejlődés
Authors: Czető Krisztina
Published: April 2020

A tanári munka minőségének szerepe a tanulók tanulásában, előrehaladásuk támogatásában, valamint az iskolához fűződő attitűdjeik alakításában vitathatatlan, azonban a tanári minőség (minőségi tanítás) mint fogalom konceptualizálása, és az annak mérését lehetővé tevő megalapozott módszertani megközelítések még nem teljesen feltárt területek az eredményességkutatásokban (Ingwarson & Rowe, 2008; Gore, Smith, Bowe & Lubans, 2017). A folyamatos szakmai fejlődés támogatása ugyanakkor stratégiai szempontból is meghatározó szerepű a tanári munka fejlesztésében. A szakmai tanulást és fejlődést támogató tanulási helyzetek sajátosságait, azok eredményességének értelmezését jelentősen befolyásolja, ahogyan a tanári minőségről (a minőségi tanításról) gondolkodunk. Jelen tanulmány célja, hogy a folyamatos szakmai fejlődéshez és tanuláshoz kapcsolódóan értelmezze és elemezze a tanári minőség koncepciójának elméleti és kutatás alapú modelljeit, azonosítsa az eredményes szakmai fejlődést elősegítő tanulási helyzetek optimális jellemzőit, valamint azokat tényezőket, melyek befolyásolják az eredményes szakmai fejlődést/tanulást.
MAXQDA a multikódolt kvalitatív adatok elemzésében
Authors: Sántha Kálmán
Published: April 2020

Recenzió: Rädiker, S. & Kuckartz, U. (2018): Analyse qualitativer Daten mit MAXQDA – Text, Audio und Video. Wiesbaden: Springer-Verlag.
Mechanics of robot inspector on electrical transmission lines conductors with unequal heights supports
Authors: Bahrami Mohammad Reza
Published: April 2020

The aim of this paper is to create a mathematical model of the motion of robot inspector on electrical transmission lines conductors when the towers are not in one level i.e. when the tension through the conductor is not constant. In this model, we consider the electrical line as a thread with two supports at the ends with different elevations and the robot considered as a moving object on the thread. The obtained equation of motion has been solved by using the separating variables method. As the result, dangerous oscillations have been seen although the motion of the inspection robot on the line is steady. These vibrations may cause parametric vibration in the perpendicular plane of motion and can cause inertial load on the construction of the robot. To study this affect we consider the robot as a pendulum with movable suspension base. This article shows the possibility of a kind of parametric resonance.
Evaluation of safety performance during construction and servicing stages of Liuxi river bridge
Authors: Li Hao
Published: April 2020

Prestressed concrete continuous beam-arch composite bridge with concrete-filled steel tube is a new type of bridge developed in recent years. It has the characteristics of strong spanning ability and large in-plane stiffness, but the lateral stiffness of the arch ribs for this type of bridge is relatively weak. In order to effectively improve the construction quality and structure stability, and optimize the mechanical properties, and in addition of realize the design of large span continuous beam-arch composite bridge, a comprehensive safety assessment of the Liuxi River bridge during construction and serving stages located in China was conducted in this paper. The results show that the bridge had favorable safety margin during the construction and severing stages. The outcomes of this study can provide technical support for the safety and smooth implementation of the bridge’s safeguard, which has important theoretical significance and engineering application value.
Sensitivity analysis of radial defect detection of gun barrel based on ultrasonic guided wave
Authors: Wang Gao , Yuan Zhou , Zhuchen Yin
Published: April 2020

In this paper, aiming at the low efficiency of defect detection of weapon equipment, ultrasonic guided wave non-destructive testing technology is proposed to detect the radial wear defects in gun barrel which have a great impact on its combat effectiveness. At the same time, the sensitivity of different modes of L0,2 and t0,1 ultrasonic guided waves to the detection of such defects is analyzed in this paper, so as to provide theoretical guidance for the mode selection of ultrasonic guided waves in the next practical detection of gun barrel.
Electromagnetic crosstalk characteristics of micron parallel interconnects
Authors: Xu Xiaofei , Li Denghua , Yang Denghua
Published: April 2020

In the paper, the model of micron-level crosstalk interconnections was constructed based on FR4 substrate. By changing the input variables of the length and the spacing, this prediction model could provide useful information for Crosstalk intensity. With the increase of the length of the interconnect, the crosstalk intensity of the proximal end and the distal end increased. When the interconnect spacing increased, the trend of crosstalk was not changed, but the intensity decreased gradually. Which provided an experimental reference for future methods of reducing crosstalk from the perspective of physical structure.
Study on influence factors of underwater shockwave sensor dynamic calibration
Authors: Xu Hongtao , Jin Penggang , Gao Zan
Published: April 2020

To test coefficient sensitivity of underwater shockwave pressure sensor, dynamic calibration is conducted using traceable standard bench sensor and PCB913B02 sensor calibration equipment. In the research, silicon oil of different specification was filled into sealed tank in order to study the relations between silicon oil specification and calibration result of pressure sensor. Explosion tests are conducted using explosives of different formulas and underwater shockwave sensors filled with silicon oils of different specifications. The test result shows such principle and the method of calibration mentioned above could ensure the calibration precision, which therefore certifies the accuracy of shockwave pressure test.
Research on an alternative method of turbine motor signal
Authors: Sun Wei , Li Changsheng , Xue Xiaolin
Published: April 2020

In the modern mortar radio fuze, the use of turbine generators as the power source for fuzes is very common. The ballistic air pressure during the flight of the projectiles is used as the driving force to drive the turbine motor. In this paper, the turbine motor signal is parameterized in combination with the actual situation, and the idea of using the hardware to simulate the turbine power generation is proposed. The generation of the turbine motor signal is simulated by means of simulation software. Design the circuit to verify the simulation results, and have a certain reference for how to easily detect the fuze in the mass production process.
Predictive analysis of rotor machines fluid-film bearings operability
Authors: Polyakov Roman , Majorov Sergey , Kudryavcev Igor , Krupenin Nikolay
Published: April 2020

The present paper considers a multi-criteria analysis algorithm of turbo generator fluid-film bearing operability and its connection with rotor machine monitoring system data. It is substantiated that implementation of predictive analysis of load capacity, locus curves and dynamic displacements allows prognosis of useful life of a fluid-film bearings and improvement of reliability of a rotor machine.
Chromium removal from water using modified organic materials: A review
Authors: Jiménez-Castañeda Martha E. , Escamilla-García Pablo Emilio
Published: April 2020

Chromium is a non-biodegradable element predominantly found in two chemical forms, Cr(VI) and Cr(III). Several remediation strategies have been implemented to achieve its removal from aquatic environments with limited results. This review article focuses on the analysis of removal strategies including the use of: (1) raw materials (agro-wastes, activated carbons, extracts and solutions) and (2) treated materials (alkaline and acid treatments). The article also reviews and analyses results obtained with surfactant modified organic biomasses. Although this review aims to summarise chromium removal techniques by highlighting relevant results of several studies, surface modification is outlined as a promising method to improve removal efficiency in aqueous solutions. The information presented in this article can help in the development of more efficient methods considering the improvements that surfactants may offer.
The effect of irrigation using recycled waters obtained from MBR and IDAL wastewater treatment systems on soil pH and EC under kikuyu grass (Pennisetum clandestinum) production
Authors: Aghajani Shahrivar A. , Hagare D. , Maheshwari B. , Muhitur Rahman M.
Published: April 2020

The main objective of this study was to determine the effect of irrigation using three different types of waters, namely treated wastewater through membrane bioreactor (MBR) system, treated wastewater via intermittently decanted aerated lagoon (IDAL) process and tap water (TW) on soil pH and electrical conductivity (EC) under kikuyu grass production. No fertilizer was added during the study period (1 year). Irrigation waters and water and soil samples extracted from different soil depths were analysed in laboratory. Considerable changes occurred in soil characteristics over the study period under various treatments. Soil pH increased more than 1 unit under irrigation with treated wastewater produced by the IDAL system while soil irrigated with treated wastewater from the MBR treatment system showed little change and TW irrigated soil evidenced a slight decrease when compared to pH at the beginning of the study. There was also a remarkable increase recorded for EC1:5 of top soils irrigated with treated wastewaters compared to the initial EC of the soil. The results from this study highlighted the benefits of irrigation with treated wastewater from the MBR system due to its lower cost of treatment compared to the IDAL process while providing additional nutrients such as nitrogen and phosphorus from the wastewater for plant growth.
Implementation of an environmental decision support system for controlling the pre-oxidation step at a full-scale drinking water treatment plant
Authors: Godo-Pla Lluís , Emiliano Pere , González Santiago , Poch Manel , Valero Fernando , Monclús Hèctor
Published: April 2020

Drinking water treatment plants (DWTPs) face changes in raw water quality, and treatment needs to be adjusted to produce the best water quality at the minimum environmental cost. An environmental decision support system (EDSS) was developed for aiding DWTP operators in choosing the adequate permanganate dosing rate in the pre-oxidation step. To this end, multiple linear regression (MLR) and multi-layer perceptron (MLP) models are compared for choosing the best predictive model. Besides, a case-based reasoning (CBR) model was approached to provide the user with a distribution of solutions given similar operating conditions in the past. The predictive model consisted of an MLP and has been validated against historical data with sufficient good accuracy for the utility needs (R2 = 0.76 and RSE = 0.13 mg·L−1). The integration of the predictive and the CBR models in an EDSS gives the user an augmented decision-making capacity of the process and has great potential for both assisting experienced users and for training new personnel in deciding the operational set-point of the process.
Evaluating the harvesting efficiency of inorganic coagulants on native microalgal consortium enriched with human urine
Authors: Behera B. , Nageshwari K. , Darshini M. , Balasubramanian P.
Published: April 2020

Flocculation is a common technique to harvest microalgae, where the negatively charged algal cells coalesce together to form larger flocs that settle under gravity. Although several inorganic flocculants have been applied for algal biomass recovery, the dosage varies depending on the algal strain-specific features. Thus, the selection of inorganic coagulant that can be applied at a low dosage for achieving the maximal biomass recovery under normal physiological conditions is necessary. The present study analyses the influence of different inorganic flocculants like ferric chloride (FeCl3), alum, calcium hydroxide, ferrous sulphate and copper sulphate on the biomass removal efficiency of a mixed microalgal consortium isolated from the open ponds of the National Institute of Technology Rourkela and further enriched with diluted human urine. Flocculation experiments were carried out with varying coagulant dosages, pH between 7.5 and 7.8, and 0.5 g L−1 algal concentration. The results revealed that FeCl3 at the dosage of 0.05 g L−1 and KAl(SO4)2 with the dosage of 0.04 g L−1 could be utilized to achieve the biomass recovery efficiency of 99.5% and 97.9%, respectively, within a duration of 5 min. An economic evaluation of the harvesting process showed KAl(SO4)2 to be the cheapest coagulant that could be feasibly used to recover algae at a large scale.
Acción colectiva y modelos de racionalidad
Authors: Miller Moya Luis Miguel
Published: April 2020

La teoría olsoniana de la acción colectiva (Olson, 1965) asume un modelo de racionalidad económica basado en un cálculo simple de costes y beneficios, que difícilmente puede ser sostenido en la actualidad, a la luz de los modelos de racionalidad propuestos recientemente por diversas líneas de investigación. Dentro de éstas, voy a detenerme en dos propuestas concretas, a saber: la teoría de juegos evolutiva y, sobre todo, la teoría de la racionalidad limitada. Ambas alternativas se muestran especialmente fértiles a la hora de proponer modelos que no necesitan de una racionalidad maximizadora, ni de entornos de información completa y perfecta. Sus planteamientos, basados en la posibilidad de aprendizaje de los individuos a lo largo del tiempo, contribuyen al análisis del surgimiento de normas sociales, algo tan necesario para la resolución de problemas relacionados con la cooperación. Pues bien, la apuesta que se realiza en este artículo es que estas dos novedosas aportaciones posibilitan un avance fundamental en el estudio de la acción colectiva.
La línea, la frontera y la modernidad
Authors: Tejeda González José Luis
Published: April 2020

Se toma como punto de partida la discusión filosófica que se da en relación a Nietzsche y Heiddeger acerca del advenimiento del nihilismo para adentrarnos en los asuntos de la frontera en el mundo moderno y postmoderno. Esa condición existencial nos acerca a la vivencia en la frontera, al hecho de traspasar y vivir en los límites. En otras dimensiones, encontramos la actualidad de ese debate filosófico, ya que el tema fronterizo adquiere centralidad. En el terreno social, político y cultural vemos cómo la globalización nos está conduciendo a un debilitamiento de las fronteras y, paradójicamente, a un aumento en su importancia. La demarcación fronteriza sigue siendo importante, sólo que ahora tiene que vérselas con la proliferación de agentes, fuerzas y tendencias regionales y globales que hacen de la frontera una institución más borrosa y abierta. El aumento de la interdependencia lleva a que la migración y el trasiego fronterizo le estén cambiando el rostro a las comunidades nacionales del mundo actual. Los Estados nacionales se pintan de color por esos movimientos migratorios que dan lugar a la diversidad, la pluralidad y el multiculturalismo en las sociedades antes más homogéneas. Palabras clave: Línea, frontera, modernidad, pos-modernidad, nihilismo, migración.
Crafting connections: maya linkages between Guatemala’s Altiplano and El Norte
Authors: Moran-Taylor Michelle J.
Published: April 2020

International migration constitutes one of the most significant phenomena impacting Guatemala today. About a million and a half Guatemalans live and work in rural and urban cities and towns across the United States and Canada. Like many other migrant groups, most Guatemalans sustain strong transnational linkages between their homeland and el norte (the United States). In the Guatemalan example highlighted in this article, such bonds owe much to the long-standing Guatemalan-U.S. historical connections, to the geographic proximity of the country to the United States. Drawing on ethnographic material, this article examines the divergent kinds of transnational connections that Maya indigenous (K´iche´) migrants craft and keep alive between their home community and their two primary destination localities in the United States—Houston, Texas and Los Angeles, California. The article shows the different means of communication and technology, as well as the varying types of transnational organizing —particularly grass-roots efforts— that help shape current linkages between those who go and those who stay. Keyword: Transnational migration, social ties, Guatemalan Maya migration, communications, grass-roots organizing.
El poblamiento de Baja California durante el siglo XIX: reflexión desde la Historia demográfica
Authors: Magaña Mancillas Mario Alberto
Published: April 2020

La población ha sido un objeto de estudio muy poco trabajado en el ámbito académico de la historia, y mucho menos los fenómenos específicos del devenir demográfico del poblamiento de lo que hoy conocemos como el estado de Baja California, entre ellos la migración. La mayoría de las veces se ha generalizado un panorama hipotético. Con este trabajo se busca encaminar una discusión sobre el devenir demográfico de Baja California, desde una perspectiva histórica y reconociendo los diversos momentos de su poblamiento. Palabras claves: Población, migración, matriz fundacional, siglo XIX, Baja California.
N-acetyl-cysteine in Schizophrenia: Potential Role on the Sensitive Cysteine Proteome
Authors: Martínez-Banaclocha Marcos
Published: April 2020

Background:

N-acetyl-cysteine (NAC) has shown widespread utility in different psychiatric disorders, including a beneficial role in schizophrenic patients. Although the replenishment of glutathione and the antioxidant activity of NAC have been suggested as the mechanisms that improve such a wide range of disorders, no one seems to be sufficiently specific to explain these intriguing effects. A sensitive cysteine proteome is emerging as a functional and structural network of interconnected sensitive cysteine-containing proteins (SCCPs) that together with reactive species and the cysteine/glutathione cycles can regulate the bioenergetic metabolism, the redox homeostasis and the cellular growth, differentiation and survival, acting through different pathways that are regulated by the same thiol radical in cysteine residues.

Objective:

Since this sensitive cysteine network has been implicated in the pathogenesis of Parkinson and Alzheimer´s diseases, I have reviewed if the proteins that play a role in schizophrenia can be classified too as SCCPs.

Results:

I have revised the major proteins implicated in the physiopathology of schizophrenia searching for those proteins that are redox-regulated through sensitive cysteine thiols. Results show that the principal proteins playing a role in schizophrenia can be classified as SCCPs, suggesting that the sensitive cysteine proteome (cysteinet) is defective in this type of psychosis.

Conclusion:

The present review proposes that there is a deregulation of the sensitive cysteine proteome in schizophrenia as the consequence of a functional imbalance among different SCCPs, which play different functions in neurons and glial cells. In this context, the role of NAC to restore and prevent schizophrenic disorders is discussed.
δ Opioid Receptor Inverse Agonists and their In Vivo Pharmacological Effects
Authors: Hirayama Shigeto , Fujii Hideaki
Published: April 2020

The discovery of δ opioid receptor inverse agonist activity induced by ICI-174,864, which
was previously reported as an δ opioid receptor antagonist, opened the door for the investigation of
inverse agonism/constitutive activity of the receptors. Various peptidic or non-peptidic δ opioid receptor
inverse agonists have since been developed. Compared with the reports dealing with in vitro inverse
agonist activities of novel compounds or known compounds as antagonists, there have been almost no
publications describing the in vivo pharmacological effects induced by a δ opioid receptor inverse agonist.
After the observation of anorectic effects with the δ opioid receptor antagonism was discussed in
the early 2000s, the short-term memory improving effects and antitussive effects have been very recently
reported as possible pharmacological effects induced by a δ opioid receptor inverse agonist. In
this review, we will survey the developed δ opioid receptor inverse agonists and summarize the possible
in vivo pharmacological effects by δ opioid receptor inverse agonists. Moreover, we will discuss
important issues involved in the investigation of the in vivo pharmacological effects produced by a δ
opioid receptor inverse agonist.
Recent Studies on HDAC Inhibitors Acting against Prostate Cancer
Authors: Shaik Basheerulla , Zafar Tabassum , Gupta Satya P.
Published: April 2020

Prostate cancer is one of the prominent death cause in males with alarming rates of inclusion
of new cases each year. There are many new classes of anti-tumor agents already investigated
that modulate the epigenetic or non-epigenetic mechanisms such as cell cycle arrest, apoptosis, cell
death within cancer cells. Histone deacetylase (HDAC) inhibitors are one of them. In recent times,
the use of HADC inhibitors are approved as a clinical molecule to treat a group of malignancies. Vorinostat
and depsipeptide are two new HDAC inhibitors that are approved by the Food and Drug
Administration. The present review is an effort to summarize the recent findings related to HDAC
inhibitors against prostate cancer along with their molecular mechanism and biological mode of actions
behind the anticancer efficacy.
Vitamin D Levels Correlate with Metabolic Syndrome Criteria in Algerian Patients: The Ex-vivo Immunomodulatory Effect of α, 25 Dihydroxyvitamin D3
Authors: Bouchemal Meroua , Hakem Djennat , Azzouz Malha , Touil-Boukoffa Chafia , Mezioug Dalila
Published: April 2020

Background:

Metabolic syndrome (MetS) is a combination of metabolic disorders with increased risks for several diseases, such as cardiovascular diseases and diabetes. It is associated with the presence of various inflammatory molecules. Vitamin D plays an important role in the regulation of metabolism homeostasis.

Objective:

The main goal of this work is to investigate vitamin D levels among Algerian MetS patients and its possible outcomes on key molecules of the immune response, as well, the immunomodulatory effects of its active metabolite.

Methods:

We evaluated vitamin D status by the electrochemiluminescence method, Nitric Oxide (NO) levels by the Griess method and Matrix Metalloproteinases (MMPs) activities such as MMP-2 and MMP-9 by zymography in plasma of patients and healthy controls (HC). The immunomodulatory effects of the active metabolite of vitamin D (α-25 (OH)2D3) on the production of NO, IL-6, IL-10, TGF- β and s-CTLA-4 were assessed by Griess method and ELISA, in peripheral blood mononuclear cells (PBMCs) of Algerian MetS patients and HC. MMPs activities were also determined ex-vivo, while iNOS expression was assessed by immunofluorescence staining.

Results:

Severe vitamin D deficiency was registered in Algerian MetS patients. The deficiency was found to be associated with an elevated in vivo NO production and high MMPs activity. Interestingly, α-25 (OH)2D3 declined the NO/iNOS system and IL-6 production, as well as MMPs activities. However, the ex-vivo production of IL-10, TGF-β increased in response to the treatment. We observed in the same way, the implication of s-CTLA-4 in MetS, which was markedly up-regulated with α-25 (OH)2D3.

Conclusion:

Our report indicated the relationship between MetS factors and Vitamin D deficiency. The ex-vivo findings emphasize its impact on maintaining regulated immune balance.
Towards early sepsis detection from measurements at the general ward through deep learning (Preprint)
Authors: Oei Sebastiaan Pascal , van Sloun Ruud Johannes Gerardus , van der Ven Myrthe , Korsten Hendrikus Hubertus Maria , Mischi Massimo
Published: April 2020

BACKGROUND

Sepsis is one of the leading causes of death in the hospital. Several warning scores have been developed to categorize patients’ degrees of illness, with the purpose of recognizing sepsis development at an early stage and consequently reducing time before starting treatment. The most accurate classification method, known as the SOFA score, is developed for use in the intensive care unit (ICU).

OBJECTIVE

Sepsis is not exclusively developing in the ICU and may occur in any hospitalized patient. Therefore, a method for sepsis recognition outside the ICU is of major importance.

METHODS

Recently, the use of computational methods has been proposed for early sepsis prediction. Multiple sepsis classifiers have been devised using machine learning methods. We validated the linear classification model devised by Calvert et al. and improved upon it using a deep neural network trained on data from the MIMIC-III database.

RESULTS

The reference model based on Calvert et al. approach yielded an AUROC of 0.81 for a 3-hour prediction time. The deep neural network outperformed the linear model, reaching an AUROC of 0.85 for a 3-hour prediction time.

CONCLUSIONS

Our results are comparable to the high-resolution model derived by Nemati et al. yet using only 8 simple and commonly performed measurements, instead of the complex set of 65 measurements leveraged by Nemati et al. Therefore, sepsis prediction may also be viable in less monitored environments in the hospital, such as the general ward and the emergency room.
A digital health platform for assisting in diagnosing and monitoring disease progression of COVID-19: An adjuvant approach for augmenting the anti-viral response and reducing the immune-mediated target organ damage (Preprint)
Authors: Ilan Yaron , Isahy Yuval , Potruch Assaf , Schwartz Asaf , Berg Marc , Jamil Khurram , Agus Samuel
Published: April 2020

BACKGROUND

The outbreak of a coronavirus disease in 2019 (COVID-19) which is associated with respiratory-related illness and high mortality presents a major worldwide need. Problems of information availability to health care providers; difficulties in diagnosis and disease prognosis; and a lack of monitoring tools are some of the obstacles faced by the clinical community. Most importantly, the lack of valid therapies makes the pandemic a devastating universal problem. Current information points to a concept of dysregulation of the immune system which is unable to mount an effective anti-viral response, and on the other hand induces an uncontrolled immune-mediated response manifesting as ARDS, myocarditis and hepatitis.
 

OBJECTIVE

In the present paper we describe a novel platform for providing information to physicians, and assisting in diagnosis and monitoring of patients with COVID-19.

METHODS

Review of the relevant literature publications

RESULTS

An adjuvant approach is presented, using compounds that can boost a beneficial anti-viral immune response while reducing the immune-mediated target organ damage associated with the virus.

CONCLUSIONS

Ensuring a prolonged beneficial effect is performed by implementing algorithm-based individualized variability measures into the treatment regimen.
Detection of SARS-CoV-2 RNA and Antibodies in Diverse Samples: Protocol to Validate the Sufficiency of Provider-Observed, Home-Collected Blood, Saliva, and Oropharyngeal Samples (Preprint)
Authors: Sullivan Patrick Sean , Sailey Charles , Guest Jodie Lynn , Guarner Jeannette , Kelley Colleen , Siegler Aaron Julius , Valentine-Graves Mariah , Gravens Laura , del Rio Carlos , Sanchez Travis Howard
Published: April 2020

BACKGROUND

The response in the United States to the coronavirus disease (COVID-19) pandemic has been hampered by a lack of aggressive testing for the infection. Testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cornerstone of an effective public health response. However, efforts to test have been hampered by limited reagents, limitations in the availability of swabs used for the collection of nasopharyngeal swab (NPS) specimens, limitations in personal protective equipment (PPE) for health care providers collecting the NPS specimens, and limitations in viral transport media for transporting the specimens. Therefore, more flexible options for screening for SARS-CoV-2 RNA and serologic responses are critical to inform clinical and public health responses.

OBJECTIVE

We aim to document the ability of patients to self-collect sufficient specimens for SARS-CoV-2 viral detection and serology.

METHODS

Patient self-collection of samples will be done with observation by a health care provider during a telemedicine session. Participants will be mailed a specimen collection kit, engage in a telehealth session with a provider through a HIPPA (Health Insurance Portability and Accountability Act of 1996)-compliant video meeting, and collect specimens while being observed by the provider. Providers will record whether they are confident in the suitability of the specimen for laboratory testing that would inform clinical decision making. We will objectively assess the sufficiency of biological material in the mailed-in specimens.

RESULTS

The protocol was approved by the Emory University Institutional Review Board (IRB) on March 30, 2020 (Protocol number 371). To date, we have enrolled 159 participants.

CONCLUSIONS

Defining a conceptual framework for assessing the sufficiency of patient-collected samples for the detection of SARS-CoV-2 RNA and serologic responses to infection is critical for facilitating public health responses and providing PPE-sparing options to increase testing. Validation of alternative methods of specimen collection should include objective measures of the sufficiency of specimens for testing. A strong evidence base for diversifying testing modalities will improve tools to guide public health responses to the COVID-19 pandemic.
Predictors of Internet Use Among Older Adults With Diabetes in South Korea: Survey Study (Preprint)
Authors: Park Sunhee , Kim Beomsoo
Published: April 2020

BACKGROUND

Internet access in Korea has grown dramatically over the past two decades. However, disparities in internet use, referred to as the second level of the digital divide, persist.

OBJECTIVE

This study aims to examine opportunity, motivation, and health variables that indicate internet use among older adults with diabetes.

METHODS

Data were sourced from a nationally representative sample of people 65 years and older with diabetes (N=1919). Logistic regression was used to explore potential differences in predictor variables between internet users and nonusers.

RESULTS

Only 306 of the 1919 (15.95%) participants in the sample used the internet. They were more likely to be younger (odds ratio [OR] 0.89, 95% CI 0.87-0.92), well-educated (OR 1.20, 95% CI 1.16-1.26), and able to afford leisure expenditures (OR 1.02, 95% CI 1.01-1.04). Additionally, they had more information and communications technology (ICT) training experience, were motivated to learn, volunteered, and reported good physical and cognitive function. Participation in ICT education and better health more positively correlated with a higher rate of internet use than did years of education or economic standing in older adults with diabetes.

CONCLUSIONS

To support older adults with diabetes in the internet age, policies and health care providers should focus on digital competency training as well as physical and cognitive function.
Pengaruh Diabetes, Hipertensi, Merokok dengan Kejadian Katarak di Balai Kesehatan Mata Makassar
Authors: Harun Herlinda Mahdania , Abdullah Zulkifli , Salmah Ummu
Published: April 2020

Latar Belakang: Kebutaan dan gangguan penglihatan terbanyak diseluruh dunia adalah katarak dengan persentase 51% atau terjadi sekitar 20 juta jiwa. Angka kebutaan di Indonesia menempati urutan ketiga di dunia. Katarak merupakan penyebab utama kebutaan di Indonesia. Tujuan: Penelitian ini bertujuan untuk mengetahui risiko diabetes melitus, hipertensi, dan kebiasaan merokok, terhadap kejadian katarak pada pengunjung di Balai Kesehatan Mata Masyarakat Kota Makassar tahun 2017. Metode: Penelitian ini dilakukan dengan menggunakan desain penelitian case control. Penarikan sampel dilakukan dengan sistematik random sampling. Jumlah sampel sebanyak 150 responden umur ≥ 40 tahun dan memenuhi kriteria inklusi yang terdiri dari 75 kasus katarak dan 75 kontrol. Data dianalisis menggunakan uji Odds Ratio.Hasil: Hasil penelitian menunjukkan bahwa faktor yang signifikan berisiko terhadap kejadian katarak, yaitu diabetes melitus (OR=4,750, 95%CI: 2,352-9,594), hipertensi (OR=4,9555, 95%CI: 2,418-10,153), dan kebiasaan merokok (OR=3,696, 95%CI: 1,826-7,482).Kesimpulan: Faktor yang signifikan berisiko terhadap kejadian katarak yaitu diabetes, hipertensi, dan kebiasaan merokok. Disarankan perlunya untuk mengontrol gula darah, tekanan darah, dan berhenti merokok untuk mencegah serta deteksi dini penyakit katarak.
Studi Kebijakan Pengikutsertaan Orang Tua Terhadap Peningkatan Mutu Pendidikan Di SDN Songgokerto 3 Kota Batu
Authors: Ardiyansyah Maulidin , Juanda Ahmad
Published: April 2020

Abstract: Improving the quality of education is not only the responsibility of the government and schools. In this modern era in improving the quality of education is also the responsibility of parents. This study aims to determine 1) the form of parent participation in Elementary School Songgokerto 3 in Batu City in improving the quality of education, 2) the school's strategy in developing parent participation in Elementary School Songgokerto 3 in Batu City in improving the quality of education. This research uses a qualitative approach. This research is a qualitative study, with the type of descriptive qualitative research. The results showed that: 1) The strategy applied was to always participate in every activity carried out by the community in the school environment or parents to establish friendship and the formation of good communication with the community and parents. 2). The form of participation from parents in elementary school Songgokerto 3 Batu is in the form of thoughts such as providing input in program activities at school, skills such as providing training to students on how to make chips, personnel such as in repairing infrastructure for teaching and learning support processes such as repairing chairs or desks, money, and things.Keywords: Policy, Parental Participation, Quality of Education Abstrak: Meningkatkan kualitas pendidikan tidak hanya menjadi tanggung jawab oleh pemerintah dan sekolah. Pada era modern sekarang ini dalam meningkatkan mutu pendidikan juga menjadi tanggung jawab orang tua. Penelitian ini bertujuan untuk mengetahui 1) bentuk partisipasi orang tua di Sekolah Dasar Negeri Songgokerto 3 Kota Batu dalam meningkatkan mutu pendidikan, 2) strategi sekolah dalam menumbuh kembangkan partisipasi orang tua di Sekolah Dasar Negeri Songgokerto 3 Kota Batu dalam meningkatkan mutu pendidikan. Penelitian ini menggunakan pendekatan kualitatif. Penelitian ini merupakan penelitian yang bersifat kualitatif, dengan jenis penelitian kualitatif deskripstif. Hasil penelitian menunjukan bahwa: 1) Strategi yang diterapkan adalah dengan selalu ikut dalam setiap kegiatan yang diadakan oleh masyarakat di lingkungan sekolah atau orang tua dengan tujuan untuk menjalin silaturahmi dan terbentuknya komunikasi yang baik dengan masyarakat dan orangtua. 2). Bentuk partisipasi dari orang tua di SDN Songgokerto 3 Kota Batu berupa pemikiran seperti memberikan masukan-masukan dalam program kegiatan di sekolah, keterampilan seperti memberikan pelatihan pada siswa bagaimana cara membuat keripik, tenaga seperti dalam memperbaiki sarana prasarana pendukung proses belajar mengajar seperti memperbaiki kursi ataupun meja, uang, dan benda.Kata kunci: Kebijakan, Keikutsertaan Orang Tua, Mutu Pendidikan
El MBPQS en Ecuador: Exploración de la validez de contenido para su aplicación en figuras cuidadoras de niños con TEA
Authors: Díaz Mosquera Elena , Nóblega Magaly
Published: April 2020

El objetivo del presente estudio fue explorar la validez de contenido del Maternal Behavior for Preschoolers Q-set (MBPQS) para su aplicación en figuras cuidadoras de preescolares con trastorno del espectro autista (TEA), residentes en Ecuador. Con este propósito, se realizó una adaptación lingüística del instrumento al contexto ecuatoriano, la cual fue evaluada por tres profesionales en las áreas de Psicología, Educación Inicial y Lingüística. Con el MBPQS adaptado, 10 figuras cuidadoras ecuatorianas construyeron un perfil prototípico de cuidadores idealmente sensibles de preescolares de desarrollo típico, y 10 profesionales expertos en autismo elaboraron un perfil prototípico de figuras cuidadoras idealmente sensibles de niños con TEA. Los perfiles construidos por los dos grupos fueron comparados entre sí y con el criterio normativo del instrumento. Los resultados evidencian la validez del MBPQS para evaluar la sensibilidad de figuras cuidadoras de niños con TEA.
Actitudes de los maestros ante la inclusión de alumnos con discapacidad
Authors: Bermúdez María Martha , Navarrete Antola Ignacio
Published: April 2020

Existe desde el 2010 un marco normativo en Uruguay que dispone la equiparación de oportunidades para las personas con discapacidad. Sin embargo, las imposiciones legales no modifican la práctica docente en al aula. Este trabajo tiene el objetivo de conocer las actitudes de los docentes con la finalidad de entender su predisposición para actuar y realizar una propuesta de intervención en aula que atienda la diversidad. La población estudiada está formada por 42 docentes de educación primaria de centros educativos públicos, ubicados en localidades rurales y urbanas de Uruguay. Se aplicó la Escala de Actitudes hacia las Personas con Discapacidad (Verdugo, Arias & Jenaro, 1992). Se encontró una relación estadísticamente significativa entre la formación inicial de los maestros respecto a la actitud general, la implicación personal y el reconocimiento/negación de derechos.