bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical outcomes of immunocompromised patients on extracorporeal membrane oxygenation support for severe acute respiratory failure
Authors: Na Soo Jin , Park So Hee , Hong Sang-Bum , Cho Woo Hyun , Lee Sang-Min , Cho Young-Jae , Park Sunghoon , Koo So-My , Park Seung Yong , Chang Youjin , Kang Byung Ju , Kim Jung-Hyun , Oh Jin Young , Jung Jae-Seung , Yoo Jung-Wan , Sim Yun Su , Jeon Kyeongman
Published: October 2019

OBJECTIVES

There are limited data regarding extracorporeal membrane oxygenation (ECMO) support in immunocompromised patients, despite an increase in ECMO use in patients with respiratory failure. The aim of this study was to investigate the clinical characteristics and outcomes of immunocompromised patients requiring ECMO support for severe acute respiratory failure.

METHODS

Between January 2012 and December 2015, all consecutive adult patients with severe acute respiratory failure who underwent ECMO for respiratory support at 16 tertiary or university-affiliated hospitals in South Korea were enrolled retrospectively. The patients were divided into 2 groups based on the immunocompromised status at the time of ECMO initiation. In-hospital and 6-month mortalities were compared between the 2 groups. In addition, association of immunocompromised status with 6-month mortality was evaluated with logistic regression analysis.

RESULTS

Among 461 patients, 118 (25.6%) were immunocompromised. Immunocompromised patients were younger and had lower haemoglobin and platelet counts than immunocompetent patients. Ventilatory parameters and the use of adjunctive/rescue therapies were similar between the 2 groups, but prone positioning was more commonly used in immunocompetent patients. Successful weaning rates from ECMO (46.6% vs 58.9%; P = 0.021) was lower and hospital mortality (66.1% vs 59.8%; P = 0.22) was higher in immunocompromised patients. In addition, immunocompromised status was associated with higher 6-month mortality (74.6% vs 64.7%, adjusted odds ratio 2.10, 95% confidence interval 1.02–4.35; P = 0.045).

CONCLUSIONS

Immunocompromised patients treated with ECMO support for severe acute respiratory failure had poorer short- and long-term prognoses than did immunocompetent patients.
Morbidity and mortality of lobectomy or pneumonectomy after neoadjuvant treatment: an analysis from the ESTS database
Authors: Brunelli Alessandro , Rocco Gaetano , Szanto Zalan , Thomas Pascal , Falcoz Pierre Emmanuel
Published: October 2019

OBJECTIVES

To evaluate the postoperative complications and 30-day mortality rates associated with neoadjuvant chemotherapy before major anatomic lung resections registered in the European Society of Thoracic Surgeons (ESTS) database.

METHODS

Retrospective analysis on 52 982 anatomic lung resections registered in the ESTS database (July 2007–31 December 2017) (6587 pneumonectomies and 46 395 lobectomies); 5143 patients received neoadjuvant treatment (9.7%) (3993 chemotherapy alone and 1150 chemoradiotherapy). To adjust for possible confounders, a propensity case-matched analysis was performed. The postoperative outcomes (morbidity and 30-day mortality) of matched patients with and without induction treatment were compared.

RESULTS

8.2% of all patients undergoing lobectomies and 20% of all patients undergoing pneumonectomies received induction treatment. Lobectomy analysis: propensity score analysis yielded 3824 pairs of patients with and without induction treatment. The incidence of cardiopulmonary complications was higher in the neoadjuvant group (626 patients, 16% vs 446 patients, 12%, P < 0.001), but 30-day mortality rates were similar (71 patients, 1.9% vs 75 patients, 2.0%, P = 0.73). The incidence of bronchopleural fistula and prolonged air leak >5 days were similar between the 2 groups (neoadjuvant: 0.5% vs 0.4%, P = 0.87; 9.2% vs 9.9%, P = 0.27). Pneumonectomy analysis: propensity score analysis yielded 1312 pairs of patients with and without induction treatment. The incidence of cardiopulmonary complications was higher in the treated patients compared to those without neoadjuvant treatment (neoadjuvant 275 cases, 21% vs 18%, P = 0.030). However, the 30-day mortality was similar between the matched groups (neoadjuvant 68 cases, 5.2% vs 5.3%, P = 0.86). Finally, the incidence of bronchopleural fistula was also similar between the 2 groups (neoadjuvant 1.8% vs 1.4%, P = 0.44).

CONCLUSIONS

Neoadjuvant chemotherapy is not associated with an increased perioperative risk after either lobectomy or pneumonectomy, warranting a more liberal use of this approach for patients with locally advanced operable lung cancer.
Combining left atrial appendage closure and catheter ablation for atrial fibrillation: 2-year outcomes from a multinational registry
Authors: Phillips Karen P , Romanov Aleksandr , Artemenko Sergey , Folkeringa Richard J , Szili-Torok Tamas , Senatore Gaetano , Stein Kenneth M , Razali Omar , Gordon Nicole , Boersma Lucas V A
Published: October 2019

Aims

Clinical practice guidelines do not recommend discontinuation of long-term oral anticoagulation in patients with a high stroke risk after catheter ablation for atrial fibrillation (AF). Left atrial appendage closure (LAAC) with Watchman has emerged as an alternative to long-term anticoagulation for patients accepting of the procedural risks. We report on the long-term outcomes of combining catheter ablation procedures for AF and LAAC from multicentre registries.

Methods and results

Data were pooled from two prospective, real-world Watchman LAAC registries running in parallel in Europe/Middle-East/Russia (EWOLUTION) and Asia/Australia (WASP) between 2013 and 2015. Of the 1140 patients, 142 subjects at 11 centres underwent a concomitant AF ablation and LAAC procedure. The mean CHA2DS2-VASc score was 3.4 ± 1.4 and HAS-BLED score 1.5 ± 0.9. Successful LAAC was achieved in 99.3% of patients. The 30-day device and/or procedure-related serious adverse event rate was 2.1%. After a mean follow-up time of 726 ± 91 days, 92% of patients remained off oral anticoagulation. The rates of the composite endpoint of ischaemic stroke/transient ischaemic attack/systemic thromboembolism were 1.09 per 100 patient-years (100-PY); and for non-procedural major bleeding were 1.09 per 100-PY. These represent relative reductions of 84% and 70% vs. expected rates per risk scores.

Conclusion

The long-term outcomes from these international, multicentre registries show efficacy for all-cause stroke prevention and a significant reduction in late bleeding events in a population of high stroke risk post-ablation patients who have been withdrawn from oral anticoagulation.
Clinical characteristics and long-term clinical course of patients with Brugada syndrome without previous cardiac arrest: a multiparametric risk stratification approach
Authors: Letsas Konstantinos P , Bazoukis George , Efremidis Michael , Georgopoulos Stamatis , Korantzopoulos Panagiotis , Fragakis Nikolaos , Asvestas Dimitrios , Vlachos Konstantinos , Saplaouras Athanasios , Sakellaropoulou Antigoni , Mililis Panagiotis , Strempelas Panagiotis , Giannopoulos Georgios , Gavrielatos Gerasimos , Tzeis Stylianos , Kardamis Christoforos , Katsivas Apostolos , Deftereos Spyridon , Stavrakis Stavros , Sideris Antonios
Published: October 2019

Aims

Risk stratification in Brugada syndrome (BrS) still represents an unsettled issue. In this multicentre study, we aimed to evaluate the clinical characteristics and the long-term clinical course of patients with BrS.

Methods and results

A total of 111 consecutive patients (86 males; aged 45.3 ± 13.3 years) diagnosed with BrS were included and followed-up in a prospective fashion. Thirty-seven patients (33.3%) were symptomatic at enrolment (arrhythmic syncope). An electrophysiological study (EPS) was performed in 59 patients (53.2%), and ventricular arrhythmias were induced in 32 (54.2%). A cardioverter defibrillator was implanted in 34 cases (30.6%). During a mean follow-up period of 4.6 ± 3.5 years, appropriate device therapies occurred in seven patients. Event-free survival analysis (log-rank test) showed that spontaneous type-1 electrocardiogram pattern (P = 0.008), symptoms at presentation (syncope) (P = 0.012), family history of sudden cardiac death (P < 0.001), positive EPS (P = 0.024), fragmented QRS (P = 0.004), and QRS duration in lead V2 > 113 ms (P < 0.001) are predictors of future arrhythmic events. Event rates were 0%, 4%, and 60% among patients with 0–1 risk factor, 2–3 risk factors, and 4–5 risk factors, respectively (P < 0.001). Current multiparametric score models exhibit an excellent negative predictive value and perform well in risk stratification of BrS patients.

Conclusions

Multiparametric models including common risk factors appear to provide better risk stratification of BrS patients than single factors alone.
Social inequalities in health: duration of unemployment unevenly effects on the health of men and women
Authors: Acevedo Paula , Mora-Urda Ana I , Montero Pilar
Published: October 2019

Background

Employment status is an important determinant of health inequalities. The aim of this article is to analyze the association between duration of unemployment and the presence of cardiovascular risk factors, self-perception of health and presence of depression and anxiety, assessing differences in the effects of unemployment by sex and age.

Methods

The sample was composed of 12 123 people (52.4% men), 18 to 74 years old (mean age= 43.5 years, SD = 10.4). Logistic regression analyses were used to study the influence of duration of unemployment on health (‘0 days’, ‘≤11 months’ and ‘≥12 months’). Sex, age, level of education, employment status and time spent unemployed, as well as tobacco and alcohol use and physical activity, were considered. Morbidity variables were hypertension, hypercholesterolemia, diabetes, obesity, depression and anxiety, and a subjective health assessment.

Results

The results showed both unemployed men and women had worse outcome in health compared with their active counterparts. The risk of hypertension was presented in long-term unemployed men, which had 1.3 times more likely to suffer from hypertension. The risk of obesity was presented only in unemployed women, which had 1.5 times more risk of obesity, doubling the risk (OR= 2.2) among women under age 40. The unemployment had a protective effect against anxiety among younger women (OR = 0.53)

Conclusion

It has been observed a different influence of unemployment time on men and women’s health. The employment status should be considered in public health policy agendas with the purpose of reducing inequalities in health.
Multiscale Dynamics of Spontaneous Brain Activity Is Associated With Walking Speed in Older Adults
Authors: Zhou Junhong , Poole Victoria , Wooten Thomas , Lo On-Yee , Iloputaife Ikechukwu , Manor Brad , Esterman Michael , Lipsitz Lewis A
Published: October 2019

Background

In older adults, compromised white matter tract integrity within the brain has been linked to impairments in mobility. We contend that poorer integrity disrupts mobility by altering the processing of sensorimotor and cognitive and attentional resources in neural networks. The richness of information processing in a given network can be quantified by calculating the complexity of resting-state functional MRI time series. We hypothesized that (i) older adults with lower brain complexity, specifically within sensorimotor, executive, and attention networks, would exhibit slower walking speed and greater dual-task costs (ie, dual-task cost) and (ii) such complexity would mediate the effect of white matter integrity on these metrics of mobility.

Methods

Fifty-three older adults completed a walking assessment and a neuroimaging protocol. Brain complexity was quantified by calculating the multiscale entropy of the resting-state functional MRI signal within seven previously defined functional networks. The white matter integrity across structures of the corpus callosum was quantified using fractional anisotropy.

Results

Participants with lower resting-state complexity within the sensorimotor, executive, and attention networks walked more slowly under single- and dual-task (ie, walking while performing a serial-subtraction task) conditions (β > 0.28, p ≤ .01) and had a greater dual-task cost (β < −0.28, p < .04). Complexity in these networks mediated the influence of the corpus callosum genu on both single- (indirect effects > 0.15, 95% confidence intervals = 0.02–0.32) and dual-task walking speeds (indirect effects > 0.13, 95% confidence intervals = 0.02–0.33).

Conclusion

These results suggest that the multiscale dynamics of resting-state brain activity correlate with mobility and mediate the effect of the microstructural integrity in the corpus callosum genu on walking speed in older adults.
ApoE Genotype, Lipid Profile, Exercise, and the Associations With Cardiovascular Morbidity and 18-Year Mortality
Authors: Dankner Rachel , Ben Avraham Sivan , Harats Dror , Chetrit Angela
Published: October 2019

Background

Studies of longevity examined apolipoprotein E (ApoE), a gene involved in lipoprotein metabolism, which interacts with susceptibility to age-related diseases, and with mortality. We evaluated the association of ApoE isoforms with cardiovascular disease (CVD) and all-cause mortality.

Methods

A prospective cohort of 949 survivors of the Israel Study of Glucose Intolerance, Obesity, and Hypertension, examined during 1999–2004, mean age 72 years, was followed for mortality until 2017. Participants were interviewed for lifestyle habits and medical history. Anthropometrics and biochemical markers were taken. Logistic regression was used to assess CVD morbidity and Cox proportional hazard model for mortality.

Results

The most common genotype in the cohort was ApoE E3 (76.3%), with the other two almost equally distributed (ApoE E2 11.2% and ApoE E4 12.5%). In men only, ApoE E4 associated with CVD (adjusted odds ratio = 1.46, 95% confidence interval [CI] 0.76, 2.80) and with 18-year mortality (adjusted hazard ratio = 1.47, 95% CI 0.95, 2.26), adjusting for age, ethnicity, physical activity, hypertension, diabetes, low-density lipoprotein (LDL)-cholesterol, high-density lipoprotein (HDL)-cholesterol, triglycerides and lipid-lowering medications. Low levels of HDL cholesterol, adjusted for ApoE and the above-mentioned variables, associated with higher prevalence of CVD (adjusted odds ratio = 1.35, 95% CI 1.00, 1.83) and all-cause mortality (adjusted hazard ratio = 1.42, 95% CI 1.14, 1.78). ApoE E3 and E2 conferred a lower 18-year mortality risk in the physically active individuals, compared to the sedentary (adjusted hazard ratio = 0.57, 95% CI 0.44, 0.74, and adjusted hazard ratio = 0.53, 95% CI 0.78, 1.02, respectively).

Conclusions

In community-dwelling older adults, sociodemographic characteristics and physical activity, blood pressure and HDL-cholesterol levels, may outweigh the impact of ApoE polymorphisms on CVD morbidity and all-cause mortality.
DUX4-induced bidirectional HSATII satellite repeat transcripts form intranuclear double-stranded RNA foci in human cell models of FSHD
Authors: Shadle Sean C , Bennett Sean R , Wong Chao-Jen , Karreman Nancy A , Campbell Amy E , van der Maarel Silvère M , Bass Brenda L , Tapscott Stephen J
Published: October 2019

The DUX4 transcription factor is normally expressed in the cleavage-stage embryo and regulates genes involved in embryonic genome activation. Misexpression of DUX4 in skeletal muscle, however, is toxic and causes facioscapulohumeral muscular dystrophy (FSHD). We recently showed DUX4-induced toxicity is due, in part, to the activation of the double-stranded RNA (dsRNA) response pathway and the accumulation of intranuclear dsRNA foci. Here, we determined the composition of DUX4-induced dsRNAs. We found that a subset of DUX4-induced dsRNAs originate from inverted Alu repeats embedded within the introns of DUX4-induced transcripts and from DUX4-induced dsRNA-forming intergenic transcripts enriched for endogenous retroviruses, Alu and LINE-1 elements. However, these repeat classes were also represented in dsRNAs from cells not expressing DUX4. In contrast, pericentric human satellite II (HSATII) repeats formed a class of dsRNA specific to the DUX4 expressing cells. Further investigation revealed that DUX4 can initiate the bidirectional transcription of normally heterochromatin-silenced HSATII repeats. DUX4-induced HSATII RNAs co-localized with DUX4-induced nuclear dsRNA foci and with intranuclear aggregation of EIF4A3 and ADAR1. Finally, gapmer-mediated knockdown of HSATII transcripts depleted DUX4-induced intranuclear ribonucleoprotein aggregates and decreased DUX4-induced cell death, suggesting that HSATII-formed dsRNAs contribute to DUX4 toxicity.
Endoscopic closure of a bronchopleural fistula after pneumonectomy with the Amplatzer occluder: a step forward?
Authors: Motus Igor Ya , Bazhenov Alexander V , Basyrov Rauf T , Tsvirenko Anna S
Published: October 2019

OBJECTIVES

A bronchopleural fistula after pneumonectomy is a relatively rare but very serious complication. The development of endoscopic methods of treatment opens a new page in treating this condition. The goal of this paper was to confirm that the atrial septal defect Amplatzer device can be used for bronchopleural fistula closure in properly selected patients.

METHODS

A retrospective study of 13 patients with bronchopleural fistula after pneumonectomy was performed. There were 11 men and 2 women aged 26–70 years. Right-sided fistulas occurred in 10 patients and left-sided fistulas occurred in 3. The underlying disease was lung cancer in 7 patients and pulmonary tuberculosis in 6. Video-assisted thoracoscopic surgery (N = 7) and open-window thoracostomy (N = 6) were used to treat the empyema. To treat occlusion of the bronchial fistulas, we used Amplatzer atrial septal defect occluders originally intended for closure of ventricular and interatrial septal defects. The occluder was inserted from the bronchus by flexible bronchoscopy with the patient under local anaesthesia, with the help of video-assisted thoracoscopy or through a window thoracostomy from the pleural cavity.

RESULTS

We noted 3 complications after the procedure. In 2 patients, displacement of the occluders required re-installation in 1 patient and latissimus dorsi muscle coverage in the other. In the third patient, the occluder became dislodged during severe exacerbation of tuberculosis that occurred after the patient violated the treatment regimen. She died of tuberculosis 6 months after the occluder was inserted. The course in the remaining 10 patients was uneventful.

CONCLUSIONS

Our experience suggests that the use of an atrial septal defect occluder for the treatment of a bronchial fistula after pneumonectomy is a reliable option.
Hot Rocks and Not-So-Hot Rocks on the Seashore: Patterns and Body-Size Dependent Consequences of Microclimatic Variation in Intertidal Zone Boulder Habitat
Authors: Gunderson A R , Abegaz M , Ceja A Y , Lam E K , Souther B F , Boyer K , King E E , You Mak K T , Tsukimura B , Stillman J H
Published: October 2019

Synopsis

Microclimatic variation has emerged as an important driver of many ecological and evolutionary processes. Nonetheless, fine-scale temperature data are still rare in most habitats, limiting our ability to understand the consequences of microclimatic variation under current and future conditions. We measured fine-scale thermal variation in a common, species-rich, but rarely studied habitat with respect to temperature: the airspaces under rocks on intertidal zone boulder shores. The effects of thermal variation were investigated using physiological, behavioral, and demographic responses of the porcelain crab Petrolisthes cinctipes. Habitat temperatures were measured at fine spatial and temporal resolution over 18 months, producing 424,426 temperature records. Microclimatic variation increased with increasing intertidal elevation, particularly with respect to heat extremes. However, mean temperatures were similar across the entire intertidal zone. Overheating risk for P. cinctipes increases with intertidal elevation but is size dependent, as large animals are more heat sensitive than small animals. Still, microclimatic variation high in the intertidal zone provided thermal refugia even under the warmest conditions. Size-dependent thermal responses predicted that large crabs should be rare high in the intertidal zone, which was supported by demographic data. Furthermore, simulations parameterized by our microclimate and organismal data recapitulated demographic patterns. Therefore, interactions between microclimatic variation and size-dependent thermal responses may have significant ecological repercussions that warrant greater attention.
Change in International Society: How Not to Recreate the “First Debate” of International Relations
Authors: Friedner Parrat Charlotta
Published: October 2019

The English school of international relations is in large parts focused on the study of historical change; at the same time, however, it is remarkably unclear on how to understand change in between the idealist belief in progress and the realist eternal cycles of recurrence. This article seeks to avoid this dead end by questioning the school's understanding of change as a commonsensical concept. It is argued that change would be better understood as composed of three facets: one ontological (what is change?), one explanatory (what causes change?), and one normative (is change desirable?). This metatheoretical reconceptualization of change permits cross-checking the three facets against each other for internal coherence, but most importantly, it makes visible the underlying assumptions used to study change, so that ideas of history, causes, and normative ideals can be openly scrutinized, questioned, and defended rather than treated as self-evident. The resulting suggestion of an internally metatheoretically coherent understanding of change in international society signifies a much-needed addition to the English school tool-kit. It brings a promise of a significant metatheoretical overhaul of the theory, which, if taken up, will open up new horizons for the school. In addition, it opens up similar metatheoretical inquiries into other international relations theories’ views of change.
Circ_0000218 plays a carcinogenic role in colorectal cancer progression by regulating miR-139-3p/RAB1A axis
Authors: Pei Fu-Lai , Cao Ming-Zheng , Li Yue-Feng
Published: October 2019

Accumulating researches have confirmed that circRNA abnormal expression plays a prominent role in the progression of colorectal cancer (CRC). The role of circ_0000218 in CRC and its potential mechanism are not clear. In this study, real-time polymerase chain reaction (RT-PCR) was employed to measure the circ_0000218, miR-139-3p and RAB1A mRNA expression in CRC tissues and cells. Immunohistochemistry and western blot were conducted to determine the RAB1A expression in CRC tissues and cells, respectively. Colony formation assay and BrdU method were employed to monitor the effect of circ_0000218 on cell proliferation. Transwell assay was adopted to detect cell migration and invasion. Dual luciferase reporter assay and RNA immunoprecipitation assay were adopted to confirm the targeting relationship between circ_0000218 and miR-139-3p, miR-139-3p and RAB1A. We demonstrated that circ_0000218 was notably upregulated in CRC tissues and cell lines, and its high expression level was markedly linked to the increase of T staging and local lymph node metastasis. Circ_0000218 overexpression enhanced the proliferation and metastasis of CRC cells while knocking down circ_0000218 caused the opposite effects. We also observed that miR-139-3p was negatively regulated by circ_0000218, while RAB1A was positively regulated by it. Collectively, this study suggested that circ_0000218 upregulated RAB1A and promoted CRC proliferation and metastasis via sponging miR-139-3p.
Understanding Cryptocurrencies*
Authors: Härdle Wolfgang Karl , Harvey Campbell R , Reule Raphael C G
Published: October 2019

Cryptocurrency refers to a type of digital asset that uses distributed ledger, or blockchain, technology to enable a secure transaction. Although the technology is widely misunderstood, many central banks are considering launching their own national cryptocurrency. In contrast to most data in financial economics, detailed data on the history of every transaction in the cryptocurrency complex are freely available. Furthermore, empirically oriented research is only now beginning, presenting an extraordinary research opportunity for academia. We provide some insights into the mechanics of cryptocurrencies, describing summary statistics and focusing on potential future research avenues in financial economics.
Canid collision—expanding populations of coyotes (Canis latrans) and crab-eating foxes (Cerdocyon thous) meet up in Panama
Authors: Hody Allison W , Moreno Ricardo , Meyer Ninon F V , Pacifici Krishna , Kays Roland
Published: October 2019

The rise of the Panamanian Isthmus 3–4 million years ago enabled the first dispersal of mammals between North and South America in what is known as the Great American Biotic Interchange. Modern deforestation threatens the historic forest connectivity and creates new habitat for open-country species, as documented by recent expansions of North American coyotes (Canis latrans) and South American crab-eating foxes (Cerdocyon thous) into Central America. We used camera traps to map the expansions of these species into eastern Panama and found that, by 2015, coyote populations had colonized most agricultural area west of Lago Bayano. Most of our camera arrays east of this point documented crab-eating foxes, and evidence from roadkills showed some foxes had advanced farther west, but we never documented both species at the same camera-trap array, suggesting the possibility of fine-scale spatial avoidance. We used a data fusion approach to build species distribution models combining our camera surveys with records from the literature and roadkill. While the auxiliary data improved the predictive accuracy for both species, few clear habitat patterns emerged, which might reflect the generalist tendencies of these canids, or the fact that both are in the early stages of colonizing the region. Camera-trap photos showed that both species were nocturnal and revealed some dog-like morphology in coyotes, which could indicate their recent hybridization with dogs (Canis familiaris). Our continued monitoring of the Darién documented single coyotes moving through the western edge of the area in 2016 and 2018. This leaves only the great Darién forests between coyotes and South America. If deforestation continues in the region, these two invasive canids could represent the first of a new, Not-So-Great American Biotic Interchange, where generalist species adapted to human disturbance cross continents and threaten native biota.
Mammalian research honoring the educational contributions of Grinnell Awardee Robert M. Timm
Authors: Anderson Robert P , Eifler Maria A , Lanier Hayley C , Holmes Thorvald
Published: October 2019

This Special Feature honors Robert M. (Bob) Timm, who was recognized by the American Society of Mammalogists in 2017 with the Joseph Grinnell Award for his contributions to education in mammalogy. Bob has made great educational contributions through formal classroom and field instruction, interactions with researchers, public outreach, and mentorship of graduate students. Bob also has promoted equity and human diversity in mammalogy and joyfully assisted international colleagues (especially Latin Americans). In this Festschrift, many of his Ph.D. students offer the results of their recent mammalian research on topics as diverse as taxonomy and species identification, functional morphology, and biogeography and conservation on an environmentally dynamic planet.

Esta Sección Especial honra a Robert M. (Bob) Timm, quien fue reconocido por la American Society of Mammalogists en el 2017 con el Premio Joseph Grinnell, por sus aportes a la educación en la mastozoología. Bob ha realizado grandes contribuciones educativas dando clases en el aula y en el campo, interactuando con investigadores, involucrándose con el sector civil y asesorando a estudiantes de posgrado. Además, Bob ha promovido la igualdad y diversidad de participantes en la mastozoología, además de haber colaborado vehementemente junto a colegas internacionales (especialmente Latinoamericanos). En este homenaje, muchos de sus estudiantes de doctorado comparten los resultados recientes de sus investigaciones con mamíferos en temas tan diversos como la taxonomía e identificación de especies, la morfología funcional, y la biogeografía y conservación en un planeta medioambientalmente dinámico.
Aedes albopictus Body Size Differs Across Neighborhoods With Varying Infrastructural Abandonment
Authors: Katz Grace , Leisnham Paul T , LaDeau Shannon L
Published: October 2019

Mosquitoes pose an increasing risk in urban landscapes, where spatial heterogeneity in juvenile habitat can influence fine-scale differences in mosquito density and biting activity. We examine how differences in juvenile mosquito habitat along a spectrum of urban infrastructure abandonment can influence the adult body size of the invasive tiger mosquito, Aedes albopictus (Skuse) (Diptera: Culicidae). Adult Ae. albopictus were collected across 3 yr (2015–2017) from residential blocks in Baltimore, MD, that varied in abandonment level, defined by the proportion of houses with boarded-up doors. We show that female Ae. albopictus collected from sites with higher abandonment were significantly larger than those collected from higher income, low abandonment blocks. Heterogeneity in mosquito body size, including wing length, has been shown to reflect differences in important traits, including longevity and vector competence. The present work demonstrates that heterogeneity in female size may reflect juvenile habitat variability across the spatial scales most relevant to adult Aedes dispersal and human exposure risk in urban landscapes. Previous work has shown that failure to manage abandonment and waste issues in impoverished neighborhoods supports greater mosquito production, and this study suggests that mosquitoes in these same neighborhoods could live longer, produce more eggs, and have different vector potential.
Vaginal evisceration of small bowel
Authors: Rogers Peter , Lee Hong , Jape Kedar , Ng Zi Qin , Koong David
Published: October 2019

Evisceration of bowel through the vaginal vault is an extremely rare condition and is considered to be a surgical emergency. We present the case of an 83-year-old female who was brought to the emergency department with a vaginal prolapse complicated by evisceration of small bowel. A midline laparotomy was performed for reduction of the bowel with a subsequent vaginal repair. We present this case due to its rarity and high-reported mortality rate.
Territoriality and Globalization
Authors: Kohl Uta
Published: October 2019

This chapter challenges the commonly held view that the territorial state is fundamentally unsuited for, and incompatible with, twenty-first century manifestations of globalization in the form of ever-tightening economic integration or all-pervasive global communication networks. This is only partly true. The state—as defined and enabled by public international law around the idea of territorial sovereignty—provides the ideal mechanism for global capital and corporate activity to function and grow with maximum efficiency and minimal accountability. The territorial nation state provides the legal framework that facilitates foreign wealth accumulation through open borders, and its subsequent retention in the Global North through closed borders. At the core of this legal framework are the territorial rules under private and public international law that provide high flexibility in opening and closing borders as and when national interest demands.
The early history of digital humanities: An analysis of Computers and the Humanities (1966–2004) and Literary and Linguistic Computing (1986–2004)
Authors: Sula Chris Alen , Hill Heather V
Published: October 2019

Most commentators locate the origin of digital humanities (DH) in computational text analysis of the mid-twentieth century, beginning in 1946 with Roberto Busa’s plans for the Index Thomisticus, a massive attempt to encode nearly 11 million words of Thomas Aquinas’ writings on IBM punch cards. This event (and the narrative that follows) is found throughout the literature, leading some to believe that early DH work ‘concentrated, perhaps somewhat narrowly, on text analysis (such as classification systems, mark-up, text encoding, and scholarly editing)’ (Presner, 2010, p. 6). Others seem convinced that DH is still only text analysis or too dominated by it (Meeks, 2013)—and misguided in its approach (Fish, 2012). Meanwhile, Underwood (2017) has recently made a case for disentangling distant reading methods from DH generally, noting that the former predates and does not depend on digital technology.

This article presents an empirical perspective on the early history of DH by tracing publications in two foundational journals (Computers and the Humanities (CHum), established in 1966, and Literary and Linguistic Computing (LLC), established in 1986), with particular emphasis on media types, authors’ disciplines and locations, and teaching and learning. In doing so, we examine the extent to which early DH work focused on text analysis as well as broader trends in the early history of the field.
The effect of stellar activity on the spectroscopic stellar parameters of the young solar twin HIP 36515
Authors: Yana Galarza Jhon , Meléndez Jorge , Lorenzo-Oliveira Diego , Valio Adriana , Reggiani Henrique , Carlos Marília , Ponte Geisa , Spina Lorenzo , Haywood Raphaëlle D , Gandolfi Davide
Published: October 2019

Spectroscopic equilibrium allows us to obtain precise stellar parameters in Sun-like stars. It relies on the assumption of the iron excitation and ionization equilibrium. However, several works suggest that magnetic activity may affect chemical abundances of young active stars, calling into question the validity of this widely used method. We have tested, for the first time, variations in stellar parameters and chemical abundances for the young solar twin HIP 36515 (∼0.4 Gyr), along its activity cycle. This star has stellar parameters very well established in the literature and we estimated its activity cycle in ∼6 yr. Using HARPS spectra with high resolving power (115 000) and signal-to-noise ratio (∼270), the stellar parameters of six different epochs in the cycle were estimated. We found that the stellar activity is strongly correlated with the effective temperature, metallicity, and microturbulence velocity. The possibility of changes in the Li i 6707.8 Å line due to flares and star-spots was also investigated. Although the core of the line profile shows some variations with the stellar cycle, it is compensated by changes in the effective temperature, resulting in a non-variation of the Li abundance.
The ALPINE-ALMA [C ii] survey: a triple merger at z ∼ 4.56
Authors: Jones G C , Béthermin M , Fudamoto Y , Ginolfi M , Capak P , Cassata P , Faisst A , Le Fèvre O , Schaerer D , Silverman J D , Yan Lin , Bardelli S , Boquien M , Cimatti A , Dessauges-Zavadsky M , Giavalisco M , Gruppioni C , Ibar E , Khusanova Y , Koekemoer A M , Lemaux B C , Loiacono F , Maiolino R , Oesch P A , Pozzi F , Riechers D , Rodighiero G , Talia M , Vallini L , Vergani D , Zamorani G , Zucca E
Published: October 2019

We report the detection of [C ii] λ158 $\mu$m emission from a system of three closely separated sources in the Cosmic Evolution Survey (COSMOS) field at z ∼ 4.56 , as part of the Atacama Large Millimeter/submillimeter Array (ALMA) Large Program to INvestigate C ii at Early times (ALPINE). The two most luminous sources are closely associated, both spatially (1.6 arcsec ∼ 11 kpc) and in velocity (∼100 km s−1), while the third source is slightly more distant (2.8 arcsec ∼ 18 kpc, ∼300 km s−1). The second most luminous source features a slight velocity gradient, while no significant velocity gradient is seen in the other two sources. Using the observed [C ii] luminosities, we derive a total log$_{10}(\rm SFR_{[C\,{\small II}]}\, [M_{\odot }\, yr^{-1}])=2.8\pm 0.2$, which may be split into contributions of 59, 31, and 10 per cent from the central, east, and west sources, respectively. Comparison of these [C ii] detections to recent zoom-in cosmological simulations suggests an ongoing major merger. We are thus witnessing a system in a major phase of mass build-up by merging, including an ongoing major merger and an upcoming minor merger, which is expected to end up in a single massive galaxy by z ∼ 2.5.
Fine-Scale Haplotype Structure Reveals Strong Signatures of Positive Selection in a Recombining Bacterial Pathogen
Authors: Arnold Brian , Sohail Mashaal , Wadsworth Crista , Corander Jukka , Hanage William P , Sunyaev Shamil , Grad Yonatan H
Published: October 2019

Identifying genetic variation in bacteria that has been shaped by ecological differences remains an important challenge. For recombining bacteria, the sign and strength of linkage provide a unique lens into ongoing selection. We show that derived alleles <300 bp apart in Neisseria gonorrhoeae exhibit more coupling linkage than repulsion linkage, a pattern that cannot be explained by limited recombination or neutrality as these couplings are significantly stronger for nonsynonymous alleles than synonymous alleles. This general pattern is driven by a small fraction of highly diverse genes, many of which exhibit evidence of interspecies horizontal gene transfer and an excess of intermediate frequency alleles. Extensive simulations show that two distinct forms of positive selection can create these patterns of genetic variation: directional selection on horizontally transferred alleles or balancing selection that maintains distinct haplotypes in the presence of recombination. Our results establish a framework for identifying patterns of selection in fine-scale haplotype structure that indicate specific ecological processes in species that recombine with distantly related lineages or possess coexisting adaptive haplotypes.
Taphonomic field experiment in a freshwater shallow lake: alteration of gastropod shells below the sediment–water interface
Authors: Cristini Paula Andrea , De Francesco Claudio Germán
Published: October 2019

We conducted a taphonomic field experiment to evaluate the effects of (1) depth below the sediment–water interface (SWI) and (2) time of exposure on the accrual of damage (particularly through dissolution) to empty mollusc shells in freshwater environments. The experiment, which lasted 30 months, was carried out in the littoral area of Lake Nahuel Rucá, a shallow freshwater lake in the Pampa plain of Argentina. Bags (0.5-cm mesh) containing empty, cleaned shells of the freshwater gastropods Heleobia parchappii, Biomphalaria peregrina and Pomacea canaliculata were buried at three different depths (5, 20 and 35 cm) below the SWI. Damage was assessed every 3 months. All experimental shells exhibited fine-scale surface alteration, but the extent of this damage was relatively low, even in shells recovered after 30 months of exposure. Most of the damage consisted of minor pitting. For H. parchappii and B. peregrina, shell surface alteration varied significantly with depth, but not with time; in both species, alteration occurred mainly at the beginning of the experiment. For P. canaliculata, shell surface alteration varied significantly only with respect to time and this was the case for all three burial depths. All shells of this species exhibited a lower level of damage than what was observed for H. parchappii and B. peregrina. These differences may be related to the fact that P. canaliculata is characterized by a larger and thicker shell than the other two species. The shell attributes of larger size and greater thickness are known to confer a greater resistance to shell dissolution. In addition, the reactive surface area available for dissolution varies with shell size. Larger-sized shells have a lower potential for dissolution than smaller shells due to their lower surface-area-to-volume ratio. In contrast, species such as H. parchappii and B. peregrina, which have smaller and thinner shells, are likely to be more rapidly destroyed because they are more vulnerable to dissolution and have less preservation potential. Our results demonstrate that dissolution is a significant taphonomic process affecting shells even during burial and that the influence of dissolution on shell alteration might be significant in cases of long persistence within the taphonomically active zone. Consequently, we suggest that when working on taphofacies in the context of aquatic environments, assessments of taphonomic alteration should include changes at and below the SWI.
PADS Arsenal: a database of prokaryotic defense systems related genes
Authors: Zhang Yadong , Zhang Zhewen , Zhang Hao , Zhao Yongbing , Zhang Zaichao , Xiao Jingfa
Published: October 2019

Defense systems are vital weapons for prokaryotes to resist heterologous DNA and survive from the constant invasion of viruses, and they are widely used in biochemistry investigation and antimicrobial drug research. So far, numerous types of defense systems have been discovered, but there is no comprehensive defense systems database to organize prokaryotic defense gene datasets. To fill this gap, we unveil the prokaryotic antiviral defense system (PADS) Arsenal (https://bigd.big.ac.cn/padsarsenal), a public database dedicated to gathering, storing, analyzing and visualizing prokaryotic defense gene datasets. The initial version of PADS Arsenal integrates 18 distinctive categories of defense system with the annotation of 6 600 264 genes retrieved from 63,701 genomes across 33 390 species of archaea and bacteria. PADS Arsenal provides various ways to retrieve defense systems related genes information and visualize them with multifarious function modes. Moreover, an online analysis pipeline is integrated into PADS Arsenal to facilitate annotation and evolutionary analysis of defense genes. PADS Arsenal can also visualize the dynamic variation information of defense genes from pan-genome analysis. Overall, PADS Arsenal is a state-of-the-art open comprehensive resource to accelerate the research of prokaryotic defense systems.
Low-carbohydrate diets and cardiometabolic health: the importance of carbohydrate quality over quantity
Authors: Sievenpiper John L
Published: October 2019

Carbohydrates are increasingly being implicated in the epidemics of obesity, diabetes, and their downstream cardiometabolic diseases. The “carbohydrate-insulin model” has been proposed to explain this role of carbohydrates. It posits that a high intake of carbohydrate induces endocrine deregulation marked by hyperinsulinemia, leading to energy partitioning with increased storage of energy in adipose tissue resulting in adaptive increases in food intake and decreases in energy expenditure. Whether all carbohydrate foods under real-world feeding conditions directly contribute to weight gain and its complications or whether this model can explain these clinical phenomena requires close inspection. The aim of this review is to assess the evidence for the role of carbohydrate quantity vs quality in cardiometabolic health. Although the clinical investigations of the “carbohydrate-insulin model” have shown the requisite decreases in insulin secretion and increases in fat oxidation, there has been a failure to achieve the expected fat loss under low-carbohydrate feeding. Systematic reviews with pairwise and network meta-analyses of the best available evidence have failed to show the superiority of low-carbohydrate diets on long-term clinical weight loss outcomes or that all sources of carbohydrate behave equally. High-carbohydrate diets that emphasize foods containing important nutrients and substances, including high-quality carbohydrate such as whole grains (especially oats and barley), pulses, or fruit; low glycemic index and load; or high fiber (especially viscous fiber sources) decrease intermediate cardiometabolic risk factors in randomized trials and are associated with weight loss and decreased incidence of diabetes, cardiovascular disease, and cardiovascular mortality in prospective cohort studies. The evidence for sugars as a marker of carbohydrate quality appears to be highly dependent on energy control (comparator) and food source (matrix), with sugar-sweetened beverages providing excess energy showing evidence of harm, and with high-quality carbohydrate food sources containing sugars such as fruit, 100% fruit juice, yogurt, and breakfast cereals showing evidence of benefit in energy-matched substitutions for refined starches (low-quality carbohydrate food sources). These data reflect the current shift in dietary guidance that allows for flexibility in the proportion of macronutrients (including carbohydrates) in the diet, with a focus on quality over quantity and dietary patterns over single nutrients.
Can Posterior Reduction Replace Odontoidectomy as Treatment for Patients With Congenital Posterior Atlantoaxial Dislocation and Basilar Invagination?
Authors: Tong Huai-yu , Qiao Guang-yu , Zhao Bo , Yin Yi-heng , Li Teng , Yu Xin-guang , Zong Rui
Published: October 2019

BACKGROUND

For patients with odontoid process protrusion and basilar invagination, posterior screw–rod fixation can usually achieve satisfactory horizontal reduction, but in some cases satisfactory reduction in the vertical direction cannot be achieved at the same time.

OBJECTIVE

To propose a method for calculation of the theoretical maximum vertical reduction possible in individual patients.

METHODS

The computed tomography imaging data of patients with occipitalization and basilar invagination who were treated at our institute between January 2013 and June 2016 were retrospectively analyzed. The direction of odontoid reduction was decided by the inclination of the lateral joint. The atlanto-dental distance was assumed to be the maximum possible reduction in the horizontal direction. The maximum vertical reduction possible was calculated based on these values.

RESULTS

A total of 82 patients (34 males and 48 females) were included. The theoretical vertical reduction value was 4.2 ± 3.0 mm, which was significantly smaller than that of the dental protrusion (14.5 ± 3.8 mm, P = .000). Analysis of follow-up data (29 cases) showed that, the difference between the theoretical vertical reduction value H (4.7 ± 3.5 mm) and the actual vertical reduction value Ha (5.6 ± 3.5 mm) was not significant (P = .139).

CONCLUSION

The theoretical calculation method we proposed can well predict the actual degree of vertical reduction. The theoretical vertical reduction value is significantly lower than the odontoid protrusion value, indicating that satisfactory reduction in the vertical direction is difficult with a posterior approach alone.