bluuebunny/crossref_metadata_2025 huggingface dataset:
PHÂN TÍCH CHI PHÍ SỬ DỤNG THUỐC ĐIỀU TRỊ CHO NGƯỜI BỆNH ĐÁI THÁO ĐƯỜNG CÓ BẢO HIỂM Y TẾ TẠI BỆNH VIỆN LÊ VĂN THỊNH NĂM 2022
Authors: Lã Thanh Duy , Lã Thanh Duy , Hoàng Thy Nhạc Vũ , Lê Phước Thành Nhân , Trần Văn Khanh , Nguyễn Phi Hồng Ngân
Published: July 2023

Mục tiêu: Phân tích chi phí sử dụng thuốc trong điều trị cho người bệnh đái tháo đường (ĐTĐ) có bảo hiểm y tế (BHYT) tại bệnh viện Lê Văn Thịnh (BVLVT) năm 2022. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang, hồi cứu dữ liệu liên quan đến người bệnh ĐTĐ có BHYT tại BVLVT năm 2022 để mô tả chi phí sử dụng thuốc điều trị cho người bệnh theo phân nhóm thuốc, hoạt chất, đường dùng, nước sản xuất, nội/ngoại trú. Kết quả: Năm 2022, có 94 thuốc tương ứng với 25 hoạt chất được BVLVT sử dụng để điều trị cho người bệnh ĐTĐ có BHYT, với tổng chi phí sử dụng thuốc là 27,910 tỷ đồng. Thuốc sản xuất tại Việt Nam chiếm 22,2% chi phí, và 77,8% chi phí còn lại liên quan đến các thuốc có nguồn gốc từ 13 quốc gia khác; trong đó, thuốc có nguồn gốc từ châu Âu chiếm 48,2% chi phí sử dụng thuốc. Khi xem xét chi phí sử dụng theo nhóm thuốc, nhóm thuốc insulin chiếm 27,0% tổng chi phí; nhóm biguanid phối hợp với nhóm thuốc DPP-4i chiếm 28,8%. Sitagliptin+metformin (50mg+1000mg) và insulin tác dụng chậm kéo dài 300UI/3ml là hai thuốc có chi phí sử dụng cao nhất, chiếm tỷ lệ lần lượt 10,5% và 5,8% tổng chi phí thuốc. Kết luận: Kết quả nghiên cứu đã cung cấp thông tin cụ thể về chi phí sử dụng thuốc cho người bệnh ĐTĐ có BHYT tại BVLVT trong một năm, giúp lãnh đạo của bệnh viện có thêm căn cứ trong việc đánh giá thực trạng sử dụng thuốc tại bệnh viện, tạo cơ sở cho những điều chỉnh trong kế hoạch phân bổ ngân sách và lựa chọn mua sắm thuốc phù hợp với tình hình thực tế tại bệnh viện cho những năm tiếp theo.
DETERMINAN KEPUASAN KONSUMEN PADA PRODUK HANPHONE DITINJAU DARI MARKETING MIX
Authors: Nadia Afrilliana  , Kholilah  , Efrina Masdaini  , Dhea Pramitha
Published: July 2023

The development of technology is very rapid so that it makes the wider community need information to meet the need for information and facilitate communication, so a cellphone is needed, many cellphone products issued by manufacturers make consumers to prefer the cellphone product they will choose, therefore it is necessary to conduct a deeper study regarding the factors that affect Product Quality,  Prices for Consumer Satisfaction of Mobile Products, This research was carried out in Pali Regency, with consumer respondents who have used Mobile Products. Data collection using questionnaires, analyzed using multiple linear Regression Analysis, Hypothesis Testing and Determination Cooefficients. The results of the coefficient of determination show that the amount of contribution to changes in Product Quality, Price and to Product Consumer Satisfaction is as large as. The results of this study show that together (test F) there is a signific influence.
Abstrak
Perkembangan teknologi sangat pesat sehingga membuat masyarakat luas membutuhkan akan sebuah informasi untuk memenuhi kebutuhan akan sebuah informasi dan memudahkan komunikasi maka di butuhkan sebuah handphone, banyak produk handphone yang di keluarkan oleh produsen membuat konsumen untuk lebih memilih produk handphone yang akan  dipilihnya, oleh sebab itu perlu dilakukan kajian lebih dalam berkenaan tentang factor yang mempengaruh Kualitas Produk, Harga terhadap Kepuasan Konsumen Produk Handphone, Penelitian ini dilakasnakan di Kabupaten Pali, dengan responden konsumen yang sudah menggunakan Produk Handphone. Pengumpulan data menggunakan kuisioner, dianalisis menggunakan Analisis Regresi linear berganda, Uji Hipotesis serta Kooefisien Determinasi. Hasil koefisien determinasi menunjukkan bahwa besarnya sumbangan terhadap perubahan Kualitas Produk, Harga dan terhadap Kepuasan Konsumen Produk sebesar. Hasil penelitian ini menunjukan bahwa secara bersama-sama (uji F) ada pengaruh signifikan antara Kualitas Produk dan Harga terhadap Kepuasan Konsumen Produk Handphone. Sedangkan secara parsial/individu (uji t) ada pengaruh signifikan Kualitas Produk, Harga terhadap Kepuasan Konsumen.
Desconstrução do discurso de combate à seca para uma perspectiva voltada para a convivência com o semiárido no ensino de Sociologia.
Authors:   , Brito Farias de Oliveira Eline
Published: July 2023

Neste trabalho buscou-se trazer discussões sobre dois conceitos (estranhamento e desnaturalização) da Sociologia como estes podem contribuir para efetivação, para desconstrução do discurso de combate à seca e reflexão sobre a ideia de convivência com o semiárido, apresentando como estes fazem parte de uma construção social e como a Sociologia enquanto disciplina no Ensino Médio pode ajudar nessa desconstrução. É notável que a identidade da região nordeste é fruto de uma construção social, a imagem do semiárido brasileiro está direta e historicamente ligada à imagem de miséria e seca, durante muito tempo difundia-se discursos como uma região que não oferecia potencial desenvolvimentista. Com passar do tempo, intelectuais perceberam que a ideia não é combate à seca, mas convivência com a seca, assim buscaram apresentar alternativas viáveis para solucionar os problemas advindos da estiagem, com o intuito de possibilitar uma vida digna e a permanência das pessoas que residem no semiárido. A metodologia ancorou-se à revisão bibliográfica, ou dissertação, usando como base artigos científicos, livros e materiais da Internet. Este trabalho tem por intuito explicar como foi a construção de um material pedagógico, um E- Book, que tem por objetivo auxiliar os professores de Sociologia especificamente da região semiárida. Vale salientar que este será disponibilizado na internet, tendo em vista que estamos numa sociedade onde as pessoas tem acesso à Internet em diversos espaços, é necessário que o professor incorpore em sua prática escolar ferramentas consideradas inovadoras. Desse modo,este trabalho desenvolveu uma ferramenta de ensino de baixo custo e com relevante potencial para ser usada nas aulas de Sociologia no Ensino Médio. Este E-book apresenta o conteúdo de combate à seca e a convivência com o semiárido. Ao dispor esse material de forma aberta e gratuita, acredita-se que será uma ferramenta de ensino útil para o professor, bem como para o aluno, tornando-o essencialmente ativo na construção do seu próprio conhecimento. Espera-se que dentro das aulas de Sociologia o aluno entenda como esse discurso sobre a Região Nordeste foi criado possibilitando uma discussão que os torne protagonista de mudança na realidade nordestina.
A temática indígena na sala de aula: intervenção pedagógica para as aulas de sociologia no ensino médio.
Authors:   , Fernanda da Silva Anessa
Published: July 2023

Esta dissertação trata de uma intervenção pedagógica sobre como trabalhar com a temática indígena nas aulas de Sociologia do Ensino Médio. O objetivo geral da intervenção pedagógica consiste em contribuir com o processo de ensino para professores e professoras de Sociologia sobre a temática indígena na sala de aula, através de textos e referências que descolonize os livros didáticos, e que contribuam no processo de desnaturalização e problematização da realidade dos povos indígenas. Adotamos como abordagem teórica a perspectiva Sociológica pós-colonial de Santos (2002) a Pedagogia decolonial e a interculturalidade crítica de Arroyo (2014) e Walsh, (2009), na busca de romper com as narrativas eurocêntricas e conhecermos outras pedagogias e novas formas de reeducar a sensibilidade do pensamento, para além das pedagogias hegemônicas. Realizamos uma pesquisa qualitativa seguindo as etapas propostas por Minayo (2012), e de cunho exploratório de Gil (2008), usando do instrumento de coleta de dados a entrevista semiestruturada de acordo com as ideias de Triviños (1988). Utilizamos os conceitos sociológicos como o de marginalização, estigma, cultura e identidade, e dos conceitos antropológicos como o de índio, indígenas, povos indígenas, tribos, alteridade, relativismo cultural e etnocentrismo, de forma estratégica para trabalhar com a temática indígena nas aulas de Sociologia, uma vez que, não existe um capítulo específico no livro didático que aborde as questões indígenas. Os conceitos são trabalhados no sentido de descolonizar e decolonizar os equívocos que são construídos e reproduzidos sobre os povos tradicionais. Para tanto, organizamos e desenvolvemos a intervenção pedagógica através de uma sequência didática, que, consiste em etapas continuadas sobre como trabalhar com a temática. As etapas foram desenvolvidas com docentes que participaram do estudo e da entrevista semiestruturada. Para finalizar criamos três propostas de sequências didáticas de aulas que ficarão disponíveis para quem tem interesse pela área, assim como, para docentes que pretendem abordar as questões dos povos tradicionais. As sequências didáticas de aulas contêm dicas metodológicas, de materiais, de documentários e de atividades. Os resultados encontrados nas entrevistas com professores e professoras nos mostram os principais elementos que dificultam a presença da temática indígena na sala de aula, sendo eles: lacuna na formação inicial do pessoal do corpo docente durante a graduação, falta de formação inicial e continuada sobre a temática e a Lei 11.645/08, falta de apoio da secretária de educação, falta de apoio da própria escola, falta de material didático e a falta da temática indígena presente no PPP das escolas.
IMPACT OF NATIONAL HIGHWAY (NH-22) EXPANSION ACTIVITIES ON SOIL MICROBIAL DIVERSITY IN FOREST LOCATED ALONG SHOGHI-SHIMLA DHALI BYPASS, HIMACHAL PRADESH, INDIA
Authors: BANYAL SHELLY , AGGARWAL R.K. , BHARDWAJ S.K.
Published: July 2023

The study was conducted to analyze the impact of highway expansion activity on soil microbial diversity. The study area was divided into four equal sites based on distances viz. Site 1, Site 2, Site 3 and Site 4. The surface soil samples from each site were collected at three horizontal distances from the edge of the National Highway during pre- monsoon and post-monsoon seasons. The horizontal distances to collect the soil data considered were 0–10-meter, 10-10 meter and > 20 meter which were replicated four times in randomized block design. The total microbial count in the surface soil lies in between from 31 x 106 cfu /g to 156 x 106 cfu/g. The highest value of total microbial count 156 x 106 cfu /g was recorded in pre-monsoon season at a distance of > 20 m at Dhali and lowest of 31 x 106 cfu /g at a distance of 0-10 m in post-monsoon season at Raghanv. The spatial variation showed an increasing trend with the increasing distances from the highway
EFFECT OF EXTRUSION PARAMETERS ON PHYSICAL PROPERTIES OF TUR DAL (PIGEON PEA) ANALOGUES DEVELOPED FROM TUR DAL BROKENS
Authors: G. RAJENDER  , SATYANARAYANA CH.V.V. , RAO CH. SOMESWARA , BABU B. HARI , KUMARI B. ANILA
Published: July 2023

Dehusking and splitting are typically the steps involved in converting pulses into dal. The milling losses in commercial pulse mills can be attributed to the small brokens and fine powders found during scoring and concurrent dehusking and splitting operations. The fracture of dal kernels during the milling process is a problem in the dal milling industry, and customers don’t generally like these broken kernels. The only way to turn these unused milling fractions into profitable products is through extrusion cooking. Extrusion cooking of flour of redgram dal brokens with addition of some additives was done to prepare Tur dal analogues at various extrusion process parameters. The effect of barrel temperature (120 – 175 oC), feed moisture content (18-25%), feed rate (40-60 kg/h) and screw speed (100-220 rpm) on bulk density, expansion ratio and hardness of Tur dal analogues were investigated. To develop the prediction model, a central composite rotable design (CCRD) using response surface method (RSM) was applied. Each variable’s impact on the responses was measured via regression equations. The second-order quadratic regression model fit the variation adequately. The significance was established at p0.05. An increase in bulk density and decrease in expansion ratio with increase in feed moisture content and feed rate was observed. The bulk density and hardness increased as the barrel temperature increased when the feed moisture content was lower; conversely, when the feed moisture content was higher, the bulk density and hardness reduced as the barrel temperature increases.
Rehabilitation Of A Partially Dentatepatient With A Maxillary Cast Partial Denture And Mandibular Overdenture - A Case Report
Authors: BANSOD AKANKSHA
Published: July 2023

Using natural teeth as denture abutments can significantly slow the progression of residual ridge resorption.The abutments and the denture bearing areas can share the stress concentration. Overdentures can help reduce residual ridge resorption by providing sensory feedback, occlusal stability loss, aesthetics loss, and compromised mastication. Overdenture has been shown to be effective in reducing residual ridge resorption and increasing retention and stability. When edentulous areas are too large or numerous for fixed prosthesis and cross arch stabilisation is required, a cast partial denture is preferred. Insertion and removal of the denture, as well as regular oral hygiene, are simple procedures. The current case-report describes the rehabilitation of a partially dentate mouth using a maxillary castpartial denture and mandibular overdenture.
Kajian Living Qur’an di Pondok Pesantren Guna Menanggulangi Kekerasan Verbal Pada Anak
Authors: Rais Neily Fitriyah Suparman , Jamalin Fakron , Hermansyah Yudisthira Ade
Published: July 2023

Several cases of verbal violence against children occur in the surrounding environment. This is the background for parents in Indonesia, to entrust their children's education to Islamic boarding schools because they are considered to be a safe place from acts of violence. This study aims to describe how Islamic boarding schools replace the role of parents in Islamic boarding schools and what kind of efforts are made by Islamic boarding schools in overcoming verbal violence in children. The research was conducted at the Nurussalam Sidogede Oku Modern Islamic Boarding School, South Sumatra. The research uses qualitative methods that focus on the phenomenon of applying the living Qur'an in the field. Data were taken from interviews and written documents from Islamic boarding schools. The results of the study concluded that efforts to overcome verbal violence against children in the modern Islamic boarding school Nurussalam sidogede were: 1) with the existence of a student dormitory, speech, behavior and manners were monitored, 2) there were rules and discipline in Islamic boarding schools based on the Qur'an and hadith, 3) implementing Islamic boarding school values ​​into children, 4) Islamic syar'iyah factors, namely lessons taken in class based on the Qur'an and hadith and then applied in the daily life of students, namely students studying verses of the Koran surah al-hujurat verse 11 regarding the prohibition of verbal violence in the Koran and then the students practice this verse and it influences the students' speech and behavior.
Effects of Bio- and Chemical Fertilizers on Growth and Soil Microbial Population of Cacao (Theobroma cacao L.) Seedlings
Authors: Victoria Kristel , Aggangan Nelly
Published: July 2023

A comparative study was done to determine the growth, microbial population, and physico- chemical properties on UF18 cacao (Theobroma cacao) seedlings when treated with chemical fertilizers and biofertilizers, either applied singly or in combination. The experimental design was randomized completely block design with five seedlings per treatment per block. Treatments used were: control, ½ recommended rate of chemical (RRC) fertilizer, RRC, MYKORICH®, MYKOCAP®, ½ RRC + MYKORICH®, ½ RRC + MYKOCAP®, RRC + MYKORICH®, and RRC + MYKOCAP®. MYKORICH® and MYKOCAP® contain 12 species of arbuscular mycorrhizal fungi isolated from stressed environments. The results showed that plant growth and physico-chemical properties were significantly improved by the application of biofertilizer than by chemical fertilizer. MYKORICH® treatment gave the highest spore count and is highly significant (p < 0.05) as compared to the other treatments with spore count ranging from 41–115.5/ 50 g soil. In terms of nitrogen-fixing bacteria count, ½ RRC treatment gave the highest (16.9 CFU x 10–5 g soil–1) bacterial count. RRC + MYKORICH® inoculation gave the highest values for most of the soil physico-chemical analysis (pH, P, K, and CEC). The positive response of cacao seedlings to mycorrhizal inoculation with or without chemical fertilizer provides a useful criterion in other agricultural lands throughout the country for crop production and sustainability.
Efektivitas Vaksinasi Rubella Dalam Pengendalian Congenital Rubella Syndrome (CRS)
Authors: Riani Riani , Hilmi Indah Laily , Salman Salman
Published: July 2023

Measles or rubella is an infectious viral infectious disease that is a public health problem globally. Congenital Rubella Syndrome (CRS) is a disease in infants caused by infection of the fetus with the rubella virus during pregnancy. CRS therapy that can be done today is by giving rubella vaccination to children, adolescents, and adult women. To determine the effectiveness of the rubella vaccine in preventing and controlling CRS cases, an article review was carried out with a literature study using secondary data in the form of journals/articles, and books. Search the database of journals and articles retrieved through the internet through the google scholar database. Based on several journal results studied, it was concluded that rubella vaccination is effective and safe to prevent and control CRS cases.
El reto de la privacidad en la era de internet
Authors: Bouzas Mendes Ricardo Esteban
Published: July 2023

Internet no conoce fronteras espaciales ni límites temporales. Las amenazas y las nuevas formas de invasión a la privacidad a través de las nuevas tecnologías son cada vez más habituales y agresivas. Por lo tanto, es necesario más que nunca mecanismos jurídicos que garanticen la privacidad a la vez que permitan el desarrollo de nuevas tecnologías para garantizar las exigencias de la ciudadanía actual. Es preciso una evolución de una serie de derechos ante las nuevas demandas y retos que han supuesto estos avances en la sociedad. El ejemplo paradigmático de este reto jurídico ha sido el conocido como «Derecho al Olvido» como contestación a la amenaza que supone para la privacidad, el libre desarrollo de la personalidad y otros derechos afines el almacenamiento ilimitado en la red de información, que pasado un tiempo, ha dejado de tener valor y que puede ser un grave obstáculos para algunas personas.
O Mundo Só Me Vê, Mas Não Me Enxerga: A Violência de Gênero no Brasil
Authors: Cerqueira Juliana Diniz
Published: July 2023

Este estudo tem como objetivo discutir as relações violentas dentro do panorama atual da pandemia de Covid-19, proporcionando reflexões sobre como o medo, tanto individual quanto coletivo, está alicerçado em questões individuais e subjetivas, mas também em vivências compartilhadas e concretas. Além disso, questões anteriores à pandemia eclodiram com maior veemência nesse período, de modo que episódios violentos contra mulheres se tornaram ainda mais frequentes, em especial, no ambiente doméstico, devido, principalmente, ao isolamento social e ao aumento do desemprego. Este trabalho utiliza uma narrativa específica construída ao longo de acompanhamento clínico a fim de promover uma reflexão mais ampla sobre o tema. Sendo assim, a geração de dados desta pesquisa apoiou-se em uma metodologia qualitativa, tendo como ilustração um fragmento clínico.
Effect of Selected Biopesticides and Chemicals against Pod Borer [Helicoverpa armigera (L.)] on Chickpea (Cicer arietinum L.)
Authors: Bhati Manoj Singh , Rajnikant Tayde Anoorag , Singh Sudhir Pratap , Chandar Ashok Sakharam
Published: July 2023

The research work was undertaken at Central Research Farm (CRF) Sam Higginbottom University of Agriculture Technology and Sciences (SHUATS), Naini, Prayagraj during Rabi season in 2022- 23. Experiment consists of eight treatments including control viz. Chlorantraniliprole 18.5 SC @ 0.3ml/lit, Emamectin benzoate 1.9 EC @ 5ml/lit, Bacillus thurigiensis 1x109 CFU/ml @ 2.5g/lit, Spinosad 45 SC @ 0.3ml/lit, Indoxcarb 14.5 SC @ 0.5ml/lit, Metarhizium anisiopilae 1x109 CFU/ml @ 2.5gm/lit, Beauvaria bassiana 1.15 % WP @ 2.5gm/lit and untreated control in Randomized Block Design (RBD) with three replications. Data was taken on the mean larval population of chickpea pod borer Helicoverpa armigera on third, seventh and fourteen days after spray. Spraying revealed that the treatment Chlorantraniliprole 18.5 SC (2.36) found to be superior followed by Spinosad 45 SC (2.70), Emamectin benzoate 1.9EC (2.77), Indoxcarb 14.5 SC (2.98), Bacillus thurigiensis 1x109 CFU/ml (3.17), Beauvaria bassiana 1.15% WP (3.45), Metarhizium anisiopilae 1x109 CFU/ml (3.79) was found to be least effective among all the treatments as compared to control (5.64). Based on yield and cost benefit ratio the best and most economical treatment was Chlorantraniliprole 18.5 SC (26.83 q/ha) (1:3.49), followed by Spinosad 45SC (23.08 q/ha) (1:2.83), Emamectin benzoate 1.9EC(20.03q/ha) (1:2.66), Bacillus thurigiensis 1x109 CFU/ml (17.50 q/ha) (1:2.32), Indoxcarb 14.5 SC (17.66 q/ha) (1:2.29), Beauvaria bassiana 1.15 % WP (12.00 q/ha) (1:1.60), Metarhizium anisiopilae 1x109 CFU/ml (11.08 q/ha) (1:1.47) and untreated control (9.08) (1:1.27) ratio.
Trends in Physician Electronic Health Record Time and Message Volume
Authors: Holmgren A Jay , Apathy Nate C. , Sinsky Christine A. , Adler-Milstein Julia , Bates David W. , Rotenstein Lisa
Published: February 2025

This cohort study uses national electronic health record data to assess patient medical advice request message volume and the time physicians spend in the records.
Moving Forward: The Marrakech Framework for Action
Authors: Rhodes Christy M. , Ó Tuama Séamus
Published: February 2025

This article summarizes the articles in this special issue of New Directions for Adult and Continuing Education, “Global Trends in Adult Education.” It also examines two contextual areas key to understanding the Marrakech Framework for Action (MFA): the history of international adult education conferences known as CONFINTEA and the work of the International Coalition for Adult Education (ICAE), the largest civil society organization dedicated to adult learning and education (ALE) and an influential partner in CONFINTEA planning and MFA drafting and ratification.
Analysis of Band Effects in One‐Dimensional Periodic Lattices Using an Enhanced Homogenization Method
Authors: Taheri Atefe , Shokooh‐Saremi Mehrdad
Published: February 2025

Optical elements based on periodic lattices are important components in optics and photonics. Numerical analysis methods such as rigorous coupled‐wave analysis are widely utilized to investigate these structures. Despite the high precision of numerical methods, the intricate periodicity of lattices hinders comprehensive physical analysis, emphasizing the need for effective homogenization techniques. The most common method, Rytov‐based homogenization, is limited to binary‐symmetrical lattices and prone to errors under oblique incidence. However, these traditional techniques remain prevalent due to the lack of better alternatives. This article introduces a novel homogenization technique that overcomes the limitations of Rytov‐based methods and addresses the intricate periodicity of photonic lattices. It provides comprehensive physical insights by calculating the effective refractive index (ng), particularly focusing on the challenging TM polarization. This homogenization technique can predict quasi‐bound states in the continuum and guided‐mode resonance spectral locations, and elucidate band effects such as mode crossing, and mode anti‐crossing for any type of rectangular one‐dimensional grating. The study examines an intricate asymmetrical multipart grating with asymmetry arising from both oblique incidence and asymmetrical profile arrangement. Notably, it reveals phenomena like invisible band flips and invisible bandgaps, which are crucial for understanding photonic band structures and are undetectable by numerical methods.
Single‐Pump‐Actuated Transformable Dual‐Mode Gripper Based on Bistable and Origami Structures for Cross‐Scale Object Grasping
Authors: Pan Tianle , Shu Jing , Zhang Huayu , Xia Shuhao , Hu Jinfei , Zhou Jianshu , Liu Yunhui , Ma Xin
Published: February 2025

The manipulation of objects of varying sizes is crucial for grippers used in logistics and smart home applications. However, conventional grippers lack cross‐scale grasping capabilities. This study presents a novel single‐pump‐actuated transformable dual‐mode gripper (SATDG) that combines vacuum suction and granular jamming to effectively grasp objects ranging from 10 to 300 mm in size, covering a vast 30‐fold range, with forces from 0.5 to 21 N. Using a bistable mechanism and origami structure, the SATDG can transform between two modes and activate them with one pressure source. Subsequently, a finite‐element analysis of the characteristics of the bistable frame and the origami structure is presented. The performances of both grasping modes of the SATDG are validated. Demonstrations have shown that the SATDG performs outstandingly in logistics and smart home scenarios.
Novel plasma biomarkers of amyloid plaque pathology and cortical thickness: Evaluation of the NULISA targeted proteomic platform in an ethnically diverse cohort
Authors: Zeng Xuemei , Sehrawat Anuradha , Lafferty Tara K. , Chen Yijun , Rawat Mahika , Kamboh M. Ilyas , Villemagne Victor L. , Lopez Oscar L. , Cohen Ann D. , Karikari Thomas K.
Published: February 2025

INTRODUCTION

Proteomic evaluation of plasma samples could accelerate the identification of novel Alzheimer's disease (AD) biomarkers. We evaluated the novel NUcleic acid Linked Immuno‐Sandwich Assay (NULISA) proteomic method in an ethnically diverse cohort.

METHODS

Plasma biomarkers were measured with NULISA in the Human Connectome Project, a predominantly preclinical biracial community cohort in southwestern Pennsylvania. Selected biomarkers were additionally measured using Simoa and Quest immunoassays and compared.

RESULTS

On NULISA, phosphorylated tau (p‐tau217, p‐tau231, and p‐tau181), glial fibrillary acidic protein (GFAP), and microtubule‐associated protein tau (MAPT‐tau) showed the top significant association with amyloid beta (Aβ) positron emission tomography (PET) status, followed by the neuroinflammation markers C‐C motif ligand 2 (CCL2), chitotriosidase 1 (CHIT1) and interleukin‐8 (CXCL8), and the synaptic marker neurogranin (NRGN). Biomarkers associated with cortical thickness included astrocytic protein chitinase‐3‐like protein 1 (CHI3L1), cytokine CD40 ligand (CD40LG), brain‐derived neurotrophic factor (BDNF), the Aβ‐associated metalloprotein TIMP3 (tissue inhibitor of metalloprotein 3), and ficolin 2 (FCN2). Furthermore, moderate to strong between‐platform correlations were observed for various assays.

DISCUSSION

NULISA multiplexing advantage allowed concurrent assessment of established and novel plasma biomarkers of Aβ pathology and neurodegeneration.

Highlights

Classical Alzheimer's disease (AD) biomarkers measured using the NUcleic acid Linked Immuno‐Sandwich Assay (NULISA) with next‐generation sequencing readout (NULISAseq) CNS panel showed strong concordance with those measured using established immunoassay methods from Quanterix and Quest, with glial fibrillary acidic protein (GFAP) and neurofilament light (NfL) exhibiting the strongest correlation.

NULISAseq proteomic analysis identified several plasma biomarkers strongly associated with AD pathology in a biracial community cohort of older adults. Notably, phosphorylated tau‐217 (p‐tau217), GFAP, and p‐tau231 displayed the strongest association with amyloid beta (Aβ) pathology, whereas brain‐derived neurotrophic factor (BDNF) was strongly associated with neurodegeneration.

We demonstrate that plasma biomarker levels could be influenced by age, sex, apolipoprotein E (APOE) genotype, and self‐identified race. Specifically, GFAP, NfL, and surfactant protein D (SFTPD) showed a strong association with age; CD63 and S100 calcium‐binding protein B (S100B) with self‐identified race; synaptosomal‐associated protein 25 (SNAP25) with APOE genotype; and serum amyloid A1 (SAA1) and superoxide dismutase 1 (SOD1) with significant sex differences.
Opportunities and Challenges of Hepatic Impairment Physiologically Based Pharmacokinetic Modeling in Drug Development—An IQ Perspective
Authors: Qosa Hisham , Younis Islam R. , Sahasrabudhe Vaishali , Sharma Ashish , Yan Jin , Galluppi Gerald , Posada Maria M. , Kanodia Jitendra Shrawan
Published: February 2025

PBPK models are gaining special interest as a drug development tool to estimate the effect of intrinsic and extrinsic factors on drug pharmacokinetics. The IQ Consortium Clinical Pharmacology Organ Impairment Working Group conducted a survey across IQ Consortium member pharmaceutical companies to understand current practices on how PBPK is used in understanding the effect of hepatic impairment (HI) on drug disposition and its impact on clinical development. Responses from 21 participants indicated that most organizations (~86%) are already using PBPK models for HI assessment. The survey results indicate that PBPK models have been influential in optimizing the design of dedicated HI study with 57% of respondents using PBPK models to inform the design elements of dedicated HI studies, and the majority of these respondents using the PBPK model to support internal decision making regarding the HI study. Additionally, the PBPK model was used by 62% of the respondents to predict drug plasma protein binding. Despite common usage of the PBPK models by drug developers, 14.3% of the respondents discussed their PBPK modeling strategy with regulatory agencies with only two cases where the regulators accepted the PBPK model. In conclusion, although the use of PBPK models to support regulatory decisions regarding drug use in HI is currently limited, its future is promising, and the success of such models needs collaboration between regulators and drug developers to shrink the knowledge gap in the use of PBPK as an impactful tool for drug development in patients with HI.
Functional trait analysis reveals the hidden stability of multitrophic communities
Authors: Yeager Mallarie E. , Hughes A. Randall
Published: February 2025

Although important for understanding how ecosystems will fare with increasing global change, the relationship between diversity and stability in multitrophic communities is still debated. Our best understanding comes from work within competitive guilds, where the relationship between stability and functional diversity is generally positive and also more direct and mechanistic than the relationship with species diversity. To expand our understanding, there is a need to examine empirically how functional trait identity relates to spatial and temporal stability within multitrophic communities relative to species identity. Here, we measured 13 functional traits of six coastal pond fish communities to examine temporal and spatial community stability through the lenses of functional trait diversity and species diversity. We found that solely considering species composition may underestimate stability. Additionally, we found spatial convergence and temporal divergence in species and trait variability, and we link this variation to processes of deterministic community assembly. Lastly, we found that correlations of species with key functional traits allow us to make inferences about how the trophic position of species relates to trait stability. Inferring community processes and making conservation decisions from species or trophic groups based on functional trait knowledge may be a viable strategy when resources are limited.
Modeling and Operation Optimization of a Hydrogen‐Compressed Natural Gas‐Integrated Energy System With Variable Hydrogen Content and Flexible Thermal Load
Authors: Chen Jing , Sun Bo
Published: February 2025

In integrated energy systems (IESs) with high share of renewable energy, converting excess electrical energy into hydrogen (H2) and mixing it with natural gas (NG) offers numerous advantages and has become a key research focus. However, IES operations are influenced by various factors, such as equipment performance, energy flow dynamics, and load management, which are often overlooked in traditional optimization approaches. This study develops a novel hydrogen‐compressed natural gas (HCNG)‐IES model and operational strategy to address these challenges. An equivalence framework is established between electricity and hybrid gas, enabling the creation of an equivalent circuit model integrating electricity, heat, HCNG, H2, and NG. This model captures the intricate interactions and dependencies amongst energy equipment, multi‐energy flow, and consumption loads. An optimized operational strategy is proposed, leveraging variable H2 content in the gas mixture and adaptable thermal loads, while accounting for the energy inertia of H2 storage and building systems to maintain supply–demand balance. Case studies reveal that incorporating HCNG technology increases renewable resources utilization, reducing operational costs, carbon emissions, and primary energy consumption by 23%, 24%, and 23%, respectively. Moreover, compared to conventional NG‐IES optimization focused solely on equipment output, the proposed HCNG‐IES approach achieves reductions of 28.12% in costs, 24.36% in carbon emissions, and 39.13% in primary energy consumption.
Study on Mine Earthquake Prediction Based on Numerical Simulation of Rock Fracture Evolution
Authors: Zhang Xiu‐Feng , Li Wei , Li A‐Tao , Gao Feng , Zhang Ning , Li Xiang , Chen Yang , Liu Chuan‐Cheng , Shi Chao‐Hong , Han Feng‐Jun , Wang Bao‐Qi
Published: February 2025

The deformation and instability of overlying strata is the root cause of roof dynamic disasters. Therefore, it is necessary to study the geomechanical behavior of overlying strata and the evolution law of three‐dimensional fracture morphology for preventing rock burst disasters and identifying the source of mine earthquakes. To solve the problem of strong mine earthquakes in Shilawusu 1208 working face (SLWS–1208) during mining, this paper takes the mechanical mechanism of the “O–X” fracture morphology of overlying strata as the starting point to discuss the deformation, instability, and failure characteristics of overlying strata and the occurrence mechanism of mine earthquake. First, a fine stope model is established according to the geology and rock strata distribution of SLWS–1208 working face. Then, using the cohesive element analysis technique and the proposed “O–X” fracture mechanics model, numerical simulation experiments are carried out to explore the spatial‐temporal evolution laws of overlying strata migration and rock fracture. Finally, the mechanical analysis results are compared with the on‐site microseismic monitoring data, and the prediction of mine seismic events and the quantitative evaluation of mine earthquake magnitude are realized.
Leveraging Artificial Intelligence–Powered Chatbots for Nonprofit Organizations: Examining the Antecedents and Outcomes of Chatbot Trust and Social Media Engagement
Authors: Cheng Yang , Wang Yuan
Published: February 2025

With the growing utilization of artificial intelligence–powered chatbot services in the realm of nonprofit communication and the increasing significance of public engagement on social media platforms, researchers are facing a pivotal question: How can nonprofit organizations effectively harness chatbot technologies to influence the public's social media engagement and foster donation intention? In this study, we explore this question by integrating theoretical insights from social exchange theory, the service robot acceptance model, and pertinent prior literature. A survey involving 591 chatbot users located in the United States was conducted to explore the interplay between the functional and emotional values attributed to chatbots and their impacts on users' trust in the World Health Organization's chatbot services, subsequently influencing social media engagement and donation intention. The findings of this study have valuable theoretical and practical implications for nonprofit organizations seeking to optimize their use of chatbot technologies, with the goals of enhancing user engagement and encouraging donation behavior.
Monitoring Cellular Energy Balance in Single Cells Using Fluorescent Biosensors for AMPK
Authors: DeCuzzi Nicholaus , Kosaisawe Nont , Pargett Michael , Cabel Markhus , Albeck John G.
Published: February 2025

5′-Adenosine monophosphate-activated protein kinase (AMPK) senses cellular metabolic status and reflects the balance between ATP production and ATP usage. This balance varies from cell to cell and changes over time, creating a need for methods that can capture cellular heterogeneity and temporal dynamics. Fluorescent biosensors for AMPK activity offer a unique approach to measure metabolic status nondestructively in single cells in real time. In this chapter, we provide a brief rationale for using live-cell biosensors to measure AMPK activity, survey the current AMPK biosensors, and discuss considerations for using this approach. We provide methodology for introducing AMPK biosensors into a cell line of choice, setting up experiments for live-cell fluorescent microscopy of AMPK activity, and calibrating the biosensors using immunoblot data.
Towards Rethinking Politics, Policy and Polity in the Anthropocene: Context and Threat to Survival
Authors: Brauch Hans Günter
Published: February 2025

Thischapterreviewsthecontroversialdiscussion on the start of the Anthropocene claiming that this change in Earth history coincided with the emergence of a new international order. During the Cold Warthis liberalorder contributed to the collapseof theSovietUnion, and the intensification of globalisation resulted in a rapid increase in GHG emissions. The collapseof the Europeansecurityorder (2022) upgraded Hobbesian geopolitics and may postpone the realisation of a climate-neutral society and economy. During the first phase of the Anthropocene (bipolarity in the Cold War) the security discourse clearly dominated. In the second phase, since the end of the Cold War (unipolarity, 1990–2022), the planetary ecological debate emerged within new forms of “governance without government” extending beyond national sovereignty. During the third phase of increased uncertainty since 24 February 2022, both discourses coexist, while in policymaking the Hobbesian logic on national sovereignty clearly dominates, and the Anthropocene narrative has been downgraded. Within the three phases of international order since 1945 the Anthropocene has not yet affected the definitions of concepts of Politik. It has been addressed in ten edited collections in Political Science and in a few monographs, without a consensus on its relevance, definitions and purpose. During the Anthropocene the creation of a new planetary environmental order to counter global environmental and climate change has not yet emerged to prevent a “hothouse Earth” and to counter possible geopolitical tipping points resulting from chaotic interactions in the Earth system.
A Short Golden Age? The Post-War Years
Authors: Woodin Tom , Vernon Keith , Shaw Linda
Published: February 2025

The euphoria of peace and hopes for a post war democracy had to be translated into practical solutions. Led by Robert Marshall, the College would enjoy a much-enlarged cohort from around the world. It embraced management education and social studies with the aid of scholarships from co-operative societies, as well as education for ‘colonial co-operators’ in a new course supported by the Colonial Office. Yet, the very forces of the labour movement, of which co-operatives formed an important part, were moving in a direction that would create dilemmas for co-operators. In fact, the end of empire, the Cold War, the introduction of the ‘welfare state’ and nationalisation of the ‘commanding heights’ of the economy gave rise to incongruous feelings in co-operative circles. At the same time as supporting emerging national ideas on education and welfare, co-operators had to adjust to a world in which centralised planning was becoming part of a new consensus. Responding actively to these changes proved to be difficult for the movement despite encouragement from the College.
Quality Assurance and Hippocampal Segmentation on Low-Field Pediatric Magnetic Resonance Images
Authors: Tapp Austin , Rouhi Rahimeh , Tanedo Jeffrey , Zanjal Shreyash , Deoni Sean , Linguraru Marius George , Lepore Natasha
Published: February 2025

Portable ultra-low-field (uLF, i.e., 0.064T) magnetic resonance imaging (MRI) offers a solution to scarce radiological alternatives of resource-limited regions; however, in such regions, MRI system operators and radiologists are novices to the underrepresented modality. Therefore, automatic methods that confirm image acquisition of appropriate quality for diagnosis and segment and measure critical anatomical structures are required to support rural sites. This paper describes our approach to two tasks presented in the LISA 2024 Challenge: (1) quality assurance of pediatric low-field MRI data using DenseNet, and (2) segmentation of the bilateral hippocampi using nnUNet. As uLF MRI natively introduces unique image quality challenges, we trained seven DenseNet264 models, each designed to detect a specific artifact type: noise, zipper, positioning, banding, motion, contrast, and distortion. Similarly, as uLF MRI struggles to offer strong anatomical delineation, we enhanced challenge provided 0.064T low-field MRI scans using a custom Super-Field Network (SFNet) to generate high-quality Super-Field (SF) images, then trained an nnUNet model on these SF images with the LISA Challenge provided hippocampi segmentations. DenseNet achieved an average accuracy of 0.827 on the validation set across different artifact categories, excelling in detecting positioning and banding artifacts, with accuracies of 0.952 and 0.90, respectively. The nnUNet model trained on SF data achieved an average Dice Similarity Coefficient (DSC) of 71% with the SF images-an improvement from 61% DSC using the same nnUNet; similar and significant improvements were obtained for HD, relative volume error, and average symmetric surface distance demonstrating the effectiveness of SF images in improving hippocampal segmentation accuracy. These results indicate that our automated methods effectively improve image quality assessment and hippocampal segmentation in uLF MRI, supporting the mission of the LISA 2024 Challenge and the potential adoption of portable MRI systems in resource-limited regions.
Kompensationslösung fluidische Kühlung
Authors: Weber Juliane , Steiert Christoph , Weber Jürgen
Published: February 2025

Die Wissenschaft hat sich dem Thema Effizienzsteigerung in der Produktionstechnik angenommen und veröffentlicht regelmäßig Entwicklungstrends und Erkenntnisse zum Stand der Forschung. In vielen Fällen hat sich gezeigt, dass das größte Energieeinsparpotenzial in der Optimierung der Nebenaggregate und deren Schaltverhalten liegt (Brecher et al. 2012). Bei den Nebenaggregaten gilt dies insbesondere für Systeme, in denen Fluide als Energieträger genutzt werden.
Prozessmodellierung des Fräs- und Schleifprozesses
Authors: Bredthauer Marc , Liu Hui , Mattfeld Patrick , Bergs Thomas , Barth Sebastian , Meurer Markus , Wrobel Christian , Augspurger Thorsten
Published: February 2025

Im Zerspanprozess, sowohl mit definierter als auch mit undefinierter Schneide, wird die eingeleitete kinetische Energie weitestgehend in Wärme umgewandelt. Die entstehende Wärme wird durch Wärmeleitung, Konvektion und Strahlung über Werkzeug, Werkstück, Kühlschmierstoff sowie Span aus dem Zerspanbereich in die Maschinenstruktur und Umgebung abgeführt. Die daraus resultierenden Änderungen des Temperaturfeldes in der Zerspanzone haben einen wesentlichen Einfluss auf die Werkzeugstandzeit und die erreichbare Werkstückqualität hinsichtlich der Randzoneneigenschaften. Bisher wurde zumeist von den Prozessparametern direkt auf die Prozesszielgrößen, wie Verschleiß, Standzeit oder Oberflächeneigenschaften geschlossen, ohne die dafür verantwortlichen physikalischen Zustandsgrößen zu kennen.
Potenzielle verhaltensökonomische Einflussfaktoren
Authors: Reimer Maximilian Vincent
Published: February 2025

Zunächst wird ein Überblick der verhaltensökonomischen Einflussfaktoren geliefert, wonach die Risikoeinstellung und der Ankereffekt ausführlicher betrachtet werden. Das Entscheidungsmodell wird dann in Bezug auf das Risiko analysiert. Für das Ankerverhalten folgt ein detaillierter Literaturüberblick.
Fazit
Authors: Reimer Maximilian Vincent
Published: February 2025

In diesem finalen Kapitel werden zunächst die Forschungsfragen rekapituliert, die zentralen Ergebnisse und Beiträge resümiert, Implikationen und Limitationen aufgezeigt sowie zukünftige Forschungsrichtungen vorgeschlagen.
Organisationale Gesundheitskompetenz in Krankenhäusern und Pflegeeinrichtungen – Stand und Perspektiven
Authors: Bitzer Eva Maria , Häberle Nicola , Rathmann Katharina , Islertas Zeynep
Published: February 2025

Hintergrund

Offen ist, zu welchem Grad Krankenhäuser und Einrichtungen der Altenpflege in Deutschland ihren Klient:innen gute gesundheitsbezogene Entscheidungen ermöglichen, d. h. organisationale Gesundheitskompetenz (oGK) zeigen, und welche Aspekte im Detail für Identifikation von Ansatzpunkten zur Förderung der oGK essenziell sind.

Methodik

Grundlage bilden 3 unabhängig voneinander durchgeführte Forschungsprojekte: (1) Befragung von Krankenhäusern (KH) und Pflegeeinrichtungen (PE; EwiKo, 2021), (2) Befragung von KH (GK-KH, 2022) und (3) ein Konsensprozess zur Reduktion eines ausführlichen Selbstbewertungsinstrumentes (SAT-OHL-Hos v1.1; 2024). In (1) und (2) einbezogen wurden alle deutschen KH sowie die 1475 PE in Sachsen und Thüringen, eingesetzt wurde der HLHO-10 (Wertebereich 1 bis 7, hohe Werte = hohe oGK). Der Konsensprozess erfolgte im WHO-Netzwerk M‑POHL mit dem Ziel der Kürzung der 141 Indikatoren um etwa 2 Drittel unter Erhalt der Tiefe und Breite des Konzeptes in 3 Schritten: Priorisierung von Indikatoren auf nationaler Ebene, Zusammenführung nationaler Voten, Konsens in der internationalen Arbeitsgruppe.

Ergebnisse

Auswertbare Fragebögen liegen von 195 PE, 62 bzw. 291 KH vor (Rücklauf: 13,2 %, 3,2 % bzw. 11 %). Die Mittelwerte der 10 Standards des HLHO-10 liegen zwischen 3,5 und 5,7. Substanzielle Unterschiede zwischen KH und PE bestehen nicht. Der Konsensprozess führte zu einem auf 54 Items reduzierten Instrument, diskutiert wurde u. a., was länderübergreifend zu erwarten ist.

Diskussion

Erstmals liegen Daten zur oGK in der stationären Pflege vor, die selbsteingeschätzte oGK der befragten Einrichtungen liegt im mittleren bis guten Bereich, mit dem auf ca. ein Drittel gekürzten SAT-OHL-Hos steht ein „kurzes ausführliches“ und international vergleichend einsetzbares Instrument zur Verfügung, dessen empirische Prüfung ansteht.