bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis of Symmetrical and Unsymmetrical Tetrahydroxybiphenyls and
their Evaluation as Amyloid-β Aggregation Inhibitors
Authors: Wicks Sarah L. , Roberts Jake A. , Hurtt Matthew J. , Hernandez Benjamin P. , Jones Jason J. , Taylor Andrea L. , Logan Jessica K. , Schreiber William J. , Murray Mouskudah G. , Crenshaw Brandy L. , Stevens Craig B. , Lammi Robin K. , Hanna James M.
Published: April 2024

Our group recently reported that the polyhydroxy aromatic compound 3,3′,4,4′-
biphenyltetrol (2a) is a successful inhibitor of amyloid-β peptide (Aβ) aggregation, decreasing Aβ
aggregation by 50 % when present in equimolar concentrations. In the present study, several additional
biphenyltetrols were prepared and examined for their in vitro activity against aggregation of Aβ
to investigate the effect of the relative positions of hydrogen-bond donors on the aggregation process.
Congo red spectral shift assays demonstrated that, of the eight (8) additional biphenyltetrol compounds
prepared, three (3) successfully inhibited the association of Aβ monomers, two symmetrical
isomers, 2,2′,5,5′-biphenyltetrol (2c), and 2,2′,3,3′-biphenyltetrol (2d), along with one unsymmetrical
isomer, 2,3′,4′,5-biphenyltetrol (2g). These results, along with the previously reported results of 2a,
strongly suggest that hydroxyl group position affects the ability of the inhibitor to bind to Aβ assemblies,
thus impacting inhibitory efficacy.
Menstrual Cycle Characteristics and Relative Factors Among Vietnamese Female Medical Students: A Cross-Sectional Study During the COVID-19 Pandemic
Authors: Pham Khanh Hoang , Nguyen Tin Hoang , Vi Thuc , Vinh Ly Hung Huynh , Phung Thu Minh , Phuong Pham Dai Nguyen , Jill Cooper Samantha
Published: April 2024

Aims:

To research menstrual cycle characteristics and related factors among Vietnamese
female medical students.

Background:

Female medical students, juggling demanding academic schedules, face the additional
challenge of managing the impact of their monthly cycles on daily routines, academic achievements,
and professional obligations.

Objective:

To investigate the factors influencing the menstrual cycle during this particularly stressful
period by surveying these students.

Methods:

This cross-sectional study was from 3rd year of female medical students studying full-time.

Results:

Individuals in the severe stress group experienced irregular periods in 100% of cases.
Dysmenorrhea was the next most prevalent abnormal symptom, affecting 39.7% of students. Furthermore,
abdominal pain and lower back pain were the most common symptoms of premenstrual
syndrome (PMS). The percentage of menorrhagia in the overweight-obesity group was almost 5
times higher than that of the other groups. Besides, central obesity increased the incidence of menorrhagia
by a factor of 19. Average to high levels of physical activity can increase the risk of having
dysmenorrhea. Remarkably, students who were affected by COVID-19 in terms of quality of life
were also more likely to experience dysmenorrhea.

Conclusion:

Although most medical students had normal menstrual cycles, abdominal pain and
lower back pain were the leading PMS. Moreover, overweight-obesity, central obesity, physical activity,
stress, and the COVID-19 pandemic may be relative factors of the menstrual cycle.
Gender Differences in Patients with Prolactinoma: Single-center
Ukrainian Experience
Authors: Voznyak Oleksandr , Zinkevych Iaroslav , Lytvynenko Andrii , Hryniv Nazarii , Ilyuk Roman , Kobyliak Nazarii
Published: April 2024

Introduction:

Prolactinomas are the most common type of pituitary gland tumors that
secrete overly prolactin. They account for approximately 60% of all hormone-secreting hypophysis
tumors.

Aim:

This study aims to analyze gender differences in patients with prolactinomas who were operated
on transsphenoidal surgery and conduct a single-center retrospective analysis of patient data.

Material and Methods:

This study evaluated the medical records of 109 patients (61 females and
48 males) from 2009 to 2019 at Feofaniya Clinical Hospital of the State Administration of Affairs
in Kyiv, Ukraine. The primary criterion for including patients was a Serum Prolactin (PRL) level
of over 100 ng/ml and the presence of a pituitary adenoma (PA) as observed on MRI. Additionally,
the histological examination needed to confirm the presence of Prolactin-Secreting Pituitary
Adenomas (PSPAs) without plurihormonal activity through both microscopy and immunohistochemical
(IHC) staining.

Results:

Significant differences in preoperative PRL levels were not observed. However, males
had significantly larger tumor sizes and prevalence of macroadenomas. In male patients, the preoperative
PLR levels showed a weak negative correlation with age (r=-0.304, p < 0.036) and a positive
correlation with tumor size (r=0.555, p < 0.001) and cavernous sinus invasion (r=0.339, p < 0.018). In females, preoperative PRL was significantly associated only with tumor size and Knosp
grade.

Conclusion:

Prolactin-Secreting Pituitary Adenomas (PSPAs) are more common in women than
men and are characterized by larger and more invasive tumors with high PRL levels at diagnosis.
The PRL level and tumor size before surgery can predict early biochemical remission in both
males and females with an accuracy of 58.3% and 68.8%, respectively.
Construction of a Cancer Stem Cell related Histone Acetylation Regulatory Genes Prognostic Model for Hepatocellular Carcinoma via Bioinformatics Analysis: Implications for Tumor Chemotherapy and Immunity
Authors: Dai Qian , Zhu Jie , Yang Jing , Zhang Chun-Yan , Yang Wen-Jing , Pan Bai-Shen , Yang Xin-Rong , Guo Wei , Wang Bei-li
Published: April 2024

Background:

Cancer stem cells (CSC) play an important role in the development of
Liver Hepatocellular Carcinoma (LIHC). However, the regulatory mechanisms between acetylation-
associated genes (HAGs) and liver cancer stem cells remain unclear.

Objective:

To identify a set of histone acetylation genes (HAGs) with close associations to liver
cancer stem cells (LCSCs), and to construct a prognostic model that facilitates more accurate prognosis
assessments for LIHC patients.

Methods:

LIHC expression data were downloaded from the public databases. Using mRNA expression-
based stemness indices (mRNAsi) inferred by One-Class Logistic Regression (OCLR),
Differentially Expressed Genes (DEGs) (mRNAsi-High VS. mRNAsi-Low groups) were intersected
with DEGs (LIHC VS. normal samples), as well as histone acetylation-associated genes
(HAGs), to obtain mRNAsi-HAGs. A risk model was constructed employing the prognostic
genes, which were acquired through univariate Cox and Least Shrinkage and Selection Operator
(LASSO) regression analyses. Subsequently, independent prognostic factors were identified via
univariate and multivariate Cox regression analyses and then a nomogram for prediction of LIHC
survival was developed. Additionally, immune infiltration and drug sensitivity analysis were performed
to explore the relationships between prognostic genes and immune cells. Finally, the expressions
of selected mRNAsi-HAGs were validated in the LIHC tumor sphere by quantitative Reverse
Transcription Polymerase Chain Reaction (qRT-PCR) assay and western blot analysis.

Results:

Among 13 identified mRNAsi-HAGs, 3 prognostic genes (HDAC1, HDAC11, and
HAT1) were selected to construct a risk model (mRNAsi-HAGs risk score = 0.02 * HDAC1 +
0.09 * HAT1 + 0.05 * HDAC11). T-stage, mRNAsi, and mRNAsi-HAGs risk scores were identified
as independent prognostic factors to construct the nomogram, which was proved to predict
the survival probability of LIHC patients effectively. We subsequently observed strongly positive
correlations between mRNAsi-HAGs risk score and tumor-infiltrating T cells, B cells and
macrophages/monocytes. Moreover, we found 8 drugs (Mitomycin C, IPA 3, FTI 277,
Bleomycin, Tipifarnib, GSK 650394, AICAR and EHT 1864) had significant correlations with
mRNAsi-HAGs risk scores. The expression of HDAC1 and HDAC11 was higher in CSC-like
cells in the tumor sphere.

Conclusion:

This study constructed a mRNAsi and HAGs-related prognostic model, which has
implications for potential immunotherapy and drug treatment of LIHC.
The Impact of Digital Self-Monitoring of Weight on Improving Diabetes Clinical Outcomes: Quasi-Randomized Study
Authors: Fundoiano-Hershcovitz ‪Yifat , Ritholz Marilyn D , Horwitz David L , Behar Ephraim , Manejwala Omar , Goldstein Pavel
Published: April 2024

Background

The management of type 2 diabetes (T2D) and obesity, particularly in the context of self-monitoring, remains a critical challenge in health care. As nearly 80% to 90% of patients with T2D have overweight or obesity, there is a compelling need for interventions that can effectively manage both conditions simultaneously. One of the goals in managing chronic conditions is to increase awareness and generate behavioral change to improve outcomes in diabetes and related comorbidities, such as overweight or obesity. There is a lack of real-life evidence to test the impact of self-monitoring of weight on glycemic outcomes and its underlying mechanisms.

Objective

This study aims to assess the efficacy of digital self-monitoring of weight on blood glucose (BG) levels during diabetes management, investigating whether the weight changes may drive glucose fluctuations.

Methods

In this retrospective, real-world quasi-randomized study, 50% of the individuals who regularly used the weight monitoring (WM) feature were propensity score matched with 50% of the users who did not use the weight monitoring feature (NWM) based on demographic and clinical characteristics. All the patients were diagnosed with T2D and tracked their BG levels. We analyzed monthly aggregated data 6 months before and after starting their weight monitoring. A piecewise mixed model was used for analyzing the time trajectories of BG and weight as well as exploring the disaggregation effect of between- and within-patient lagged effects of weight on BG.

Results

The WM group exhibited a significant reduction in BG levels post intervention (P<.001), whereas the nonmonitoring group showed no significant changes (P=.59), and both groups showed no differences in BG pattern before the intervention (P=.59). Furthermore, the WM group achieved a meaningful decrease in BMI (P<.001). Finally, both within-patient (P<.001) and between-patient (P=.008) weight variability was positively associated with BG levels. However, 1-month lagged back BMI was not associated with BG levels (P=.36).

Conclusions

This study highlights the substantial benefits of self-monitoring of weight in managing BG levels in patients with diabetes, facilitated by a digital health platform, and advocates for the integration of digital self-monitoring tools in chronic disease management. We also provide initial evidence of testing the underlying mechanisms associated with BG management, underscoring the potential role of patient empowerment.
Understanding of the Role of Context in the Experience of Disability and Assistive Technology: New Framework for AT (Preprint)
Authors: Rivas Velarde Minerva , Chavarria Varon Mario Andres , Schönenberger Klaus , Hurst Samia
Published: April 2024

UNSTRUCTURED

The immediate context in which a person lives shapes their experience of impairment and disability. Assistive technology (AT) tools are the interface between impairment and context. This article presents a new framework for the design of assistive technology. It provides a theoretical exploration of the relationship between context, assistive technology and impairment. For this, first, we examine the theoretical challenges raised by the interface AT and impairments, considering dominant conceptual models of disability. Then, we analysed the role of context in the design, distribution and use of AT. Our framework addresses the current disconnect between the population the technology aims to serve and the innovation ecosystem. Disability is very diverse, and persons with diverse impairments benefit from different technology. Because of this diversity, we focus on visual impairment. We conclude this article by laying out a new framework for the design of AT that addresses the role of the context in which a person lives and aims to enable personal freedom in it. We do it by using the lenses of the capabilities approach. Our framework goes beyond the classical approach of only looking at AT as a tool for task performance. We argue that AT becomes a conversion tool that enables disabled persons to reach full social participation, addressing the variety of social and environmental contexts in which persons with disabilities live. Finally, we provide recommendations for future research.
Participatory Design and Scenario-based Usability Evaluation of a Clinical System for the Care of People with Mood Disorders, Cordoba - Colombia (Preprint)
Authors: Gaviria-Jiménez Juan José , Pereira-Montiel Eider , Torres-Silva Ever Augusto , Flórez-Arango José Fernando
Published: April 2024

BACKGROUND

Due to the high prevalence of mental health illnesses and mood disorders, strategies involving the use of technology have been proposed to facilitate the detection and follow-up of patients.

OBJECTIVE

This article describes the usability evaluation of a system designed for treating mood disorders in the population of the Department of Cordoba, Colombia.

METHODS

A scenario-based methodology was implemented, which represented the main functionalities of the software for telehealth care. Three test cycles were conducted with the involvement of 30 users representing different roles (patients, patient' relatives, mental health clinical care personnel, and program logistics personnel). The NASA-TLX (1) and PSSUQ (2) scales were used to measure the workload and the level of effort to complete the different tasks of the system.

RESULTS

The usability evaluation results over the two test cycles were encouraging and showed PSSUQ scores of 2.2 and 2.3, respectively.

CONCLUSIONS

The workload showed improvements between both test cycles, prioritizing patient-type user-oriented interfaces.
Results of a Formative Process Evaluation of Canada’s Student Mental Health Network (Preprint)
Authors: Ecclestone Amy , Linden Brooke , Rose Jessica , Kullar Kiran
Published: April 2024

UNSTRUCTURED

Prevalence estimates for mental health issues among Canadian post-secondary students, including stress, psychological distress, and symptoms of common mental disorders continue to increase. In tandem, an increased acknowledgement of the need for comprehensive, upstream mental health promotion support for students has been highlighted. While the majority of post-secondary institutions offer some form of mental health promotion, research suggests that students are failing to access available supports due to notable barriers including lack of awareness of available resources, geographical or financial barriers, and/or lack of relevance and student interest in what is offered. Canada’s Student Mental Health Network (the Network) was created to fill these gaps, acting as a ‘one-stop shop’ for mental health education and evidence-based resources. This paper describes the results of a formative, process evaluation of the Network after approximately one year of operations. The goal was to assess acceptability and feasibility using a concurrent mixed methods evaluation design. Quantitative data collected through Google Analytics were used to assess website reach, engagement, and usership while qualitative, individual interviews provided more detailed insights into user experience and website attributes, as well as feedback on content delivery. Results provided supporting evidence for both acceptability and feasibility of the Network, in addition to identifying areas for additional content development and accessibility improvements moving forward.
Cytotoxic Activity of Tegari (Dianella nemorosa Lam.) Methanol Extract Against HeLa Cells
Authors: Karim Aditya Krishar , Sismindari S. , Asmara Widya , Istriyati I.
Published: April 2024

Dianella nemorosa Lam. also known as tegari belonging to the Liliaceae family. This plant has been utilized for Papua traditional medicine as well as anticancer agent. This research examined potential cytotoxic activity of tegari (D. nemorosa) leaves extract against cervical cancer cell line (HeLa). Methanol extract was obtained by extracting the leaves powder using methanol. Extract was then applied into HeLa cell line to find out the cytotoxic activity. MTT [3-(4,5-dimetilthiazol-2-il)2,5-difeniltetrazolium bromida) assay was used to measure the cytotoxic activity. The result indicated that D. nemorosa leaves extract possessed cytotoxic activity in HeLa cell line with IC50 values were 685,69 µg/ml, 506,43 µg/ml and 708 µg/ml at the incubation period of 24, 48 and 72 h respectively. The strongest cytotoxic was showed by methanol extract incubated in 48 h.
Practical Exploration of Myanmar Language Teaching Model in Applied-Oriented Universities under the OBE Concept: A Case Study of the Jewelry School of West Yunnan University of Applied Sciences
Authors: Cai Jiao
Published: April 2024

The outcome-oriented OBE (Outcome-Based Education) concept has far-reaching implications in the exploration of new curriculum teaching models in Applied-Oriented Universities. It helps teachers and students clarify learning goals, highlights the cultivation of practical application abilities, and provides personalized learning and evaluation methods. This concept has significant guiding value for improving students’ Myanmar language ability and application skills. This article takes the Jewelry School of West Yunnan University of Applied Sciences as an example to analyze the current situation of Myanmar language teaching in this institution. Through specific practical approaches such as clarifying teaching goals, optimizing teaching content, exploring diversified teaching methods, and reforming evaluation methods, the Myanmar language courses under the OBE concept are discussed as teaching models.
Reconnecting and Reconstructing: Taking Stock of the STLHE 2022 conference
Authors: Miller-Young Janice , Chan Eric
Published: April 2024

Academic conferences are key spaces of knowledge sharing and professional development. As a national society which has pledged to undergo “a robust examination of its attention to equity, diversity, and inclusion throughout the organization” (STLHE/SAPES 2021), we undertook an evaluation of the diversity of participants and presentation topics at the 2022 conference. This paper reports on some of the distinctive aspects of the 2022 conference as well as the findings of the evaluation such as diversity of participants by gender and ethnic identity, province, institution type, discipline, and more. While the 2022 conference was unique in many ways due to being STLHE’s first face-to-face conference since 2019, this report provides a useful baseline with which to compare the diversity of participants and presentation topics in future years. The report concludes with additional recommendations for programming decisions to support and evaluate equity, diversity, and inclusivity at future conferences.
Keywords: conference, diversity, participation, presentation topics, Society for Teaching and Learning in Higher Education
The mechanism of financing innovative activities of Russian enterprises
Authors:   Санкт-Петербургский государственный морской технический университет, Санкт-Петербург, Россия, Лариса Анатольевна Стрельникова
Published: April 2024

The current extremely difficult economic circumstances in our country require the establishment of scientific and methodological foundations for the investigation of the mechanism of financial support for innovative projects, which requires the establishment of a rational financing mechanism for the advancement of innovative endeavors by Russian enterprises. Only in this case, conditions can be created to provide innovative projects with the necessary financial resources and the possibility of their concentration on key areas of innovation policy. This is the most important factor in the social and economic development of various integrated structures and the state as a whole, including in the field of ensuring economic security. The author has carried out a comprehensive study of the main sources of financing that can be used in the innovative activities of enterprises, identified the basic elements of the financial mechanism for ensuring the implementation of innovative projects, and also proposed conceptual approaches from an investment position to the financing of innovative projects at various stages.
Transformation of political identity in the information society: limits and contradictions
Authors:   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Давид Кромвелович Григорян ,   Ростовский юридический институт МВД России, Ростов-на-Дону, Россия, Артур Ашотович Ханджян ,   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия
Published: April 2024

The article deals with the transformation of political identity and elite consciousness in the modern world. The dynamics of political identification processes in the conditions of development of information exchange of network type is problematized. The aim of the research is to study the peculiarities of the political identification process under the influence of the newest forms and practices of digital communication. Its achievement is connected with the solution of two main tasks: 1) exposition of the modern political process and its key components (identity of the political ruling “class”, its elite self-consciousness) in the context of the development of information society, multiply increased intensity of urbanization processes; 2) study of the transformation of the process of political self-determination in the conditions of involvement of political subjects and structure in the information interaction of network type, dominating at the current stage of civilizational development. The change in the practice of political thinking and political legitimization of elites is considered in the context of urbanization processes and the development of the corresponding type of network urban “chronotope”.
Russian political mythology: unconscious origins and main content
Authors:   Многофункциональный учебный центр «Evoland», Ростов-на-Дону, Россия, Владислав Алексеевич Лихотинский
Published: April 2024

The article examines Russian political mythology, a phenomenon with deep ethnopsychological and ethnocultural roots. The purpose of the article is to identify the psychological, cultural-historical, religious-symbolic foundations, as well as the basic content of the political mythology of the Russian ethnic group. Based on the approaches of K. Jung, M. Eliade, B. Malinovsky and A. Losev, as well as using historical material, the author examines the psychological origins and content of Russian political mythology as a cultural-historical and political-anthropological phenomenon. The importance of updating the political and cultural heritage in the preservation and development of Russian statehood is emphasized.
The civilizational-elitist approach: the actual change of research optics
Authors:   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Андрей Владимирович Панков
Published: April 2024

The article substantiates that the civilizational-elitist approach develops a civilizational approach in the direction of analyzing the mechanisms and necessary prerequisites for the evolution, flourishing and decline of civilizations on a cultural and value basis and actualizes the problem of the quality of elites. He demands a multivariate and pluralistic understanding of world history, adequate to the modern stage of the development of the humanities, which allows us to move away from the Western understanding of civilization and its imperative universality. In modern social and political sciences, this makes it possible to use the concepts of the "civilizational matrix", "cultural and civilizational code", "sociocultural landscape", "state-civilization" to denote the cultural and civilizational originality and uniqueness of a country and a national state that has its own value and foundations the sustainable successful socioeconomic and political development of a particular region.
Socio-cultural regulation of youth civic consciousness in the digital environment
Authors:   Санкт-Петербургский государственный электротехнический университет «ЛЭТИ» им. В. И. Ульянова (Ленина), Санкт-Петербург, Россия, Надежда Николаевна Покровская
Published: April 2024

The article is devoted to issues related to the problem of the formation and evolution of the civic position of youth in the digital environment. The authors consider traditional and digital mechanisms of sociocultural regulation of youth civic positioning. The article substantiates the need to search for methods of sociopsychological reinforcement in the process of forming a constructive civic position of young people. The authors point out that digital technologies create intermediary channels that, on the one hand, allow you to include in communication those participants who would not be able to interact without a digital environment, but on the other hand, reduce quality and weaken such effects as direct infection and copying. In this regard, an important issue for the modern digital society is the task of ensuring the transfer of knowledge and skills, the transfer of skills through the mediation of digital telecommunications technologies in remote work, study and online interaction.
European Union development assistance programmes: territorial aid allocation
Authors:   Московский государственный институт международных отношений (университет) Министерства иностранных дел Российской Федерации, Москва, Россия, Сергей Владимирович Багликов
Published: April 2024

The article deals with EU’s development aid allocation. For the sake of its own interests EU adjusts aid programs, that preserve though regional features. Based on geographic criteria, aid programs’ priorities and EU’s interests, recipients are classified into three groups: ACP countries, pre-accession countries and participants of Eastern and Mediterranean Partnerships. In ACP countries, that include least-developed countries, EU aims at economic and politic expansion by facilitation to institutional building according to the western pattern. While providing assistance to participants of Eastern and Mediterranean Partnerships EU seeks to sustain its own security by support of friendly governments and safe key-products imports. What concerns pre-accession countries, the main target is alignment in political, economic and legal spheres.
The partnership model of interaction between power elites and civil society and the problems of its formation in modern Russia
Authors:   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Никита Юрьевич Дмитриев
Published: April 2024

The relevance of the study of the partnership model of interaction between government elites and civil society and the problems of its formation in modern Russia is due to the fact that effective interaction between the state and civil society institutions can benefit both subjects under consideration and contribute to the progressive development of the country as a whole. The paper concludes that the optimal model of interaction between public authorities and civil society institutions presupposes equality of the actors under consideration: here a strong state exists along with a strong civil society, and relations between them develop according to the type of partnership. The author emphasizes that the partnership model as a special type of interaction between the state and civil society assumes that public authorities do not seek to manage nongovernmental organizations as basic structures of civil society, but, on the contrary, are focused on dialogue with NGOs, the widespread use of various "negotiation platforms" and other forms of civil dialogue. A significant obstacle to the formation of partnerships between the state and civil society, based on an equal dialogue between the government and the public, is the low level of prestige of the so-called public activity in the eyes of the vast majority of the country's population. The organization of effective interaction between public authorities and civil society structures in our country is hampered by the general attitude of the ruling political elite towards public associations, which is characterized by the desire of the authorities to exercise control over any initiatives emanating from citizens and their organizations.
Supporting Our Women Colleagues
Authors: Anderson LaKesha N. , Anaya Yohualli B. , Gilchrist Valerie
Published: April 2024

Burnout is a challenge for all of us. Many of us experience burnout and know the toll it can take on our health and well-being. This editorial focuses on the experiences of women physicians and learners by highlighting the lived experience of one woman physician, briefly examining the extensive research into women physicians’ practice, and identifying solutions that all genders can leverage to support women physicians and learners.
A. Bely’s Report on the Culture of Local History Essay
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Moskovskaya Daria S.
Published: April 2024

The transcript of Andrei Bely’s report “Culture of local history essay” at the local history section of the Organizing Committee of the Union of Soviet Writers in 1932 is published for the first time and is the first edition of an article with the same title published in 1933. Together with the report, a transcript of its discussion is published, which allowed the speaker to develop some of the provisions of his speech. The range of problems raised by Bely goes back to the history of the local history movement of the 1920s. The main provisions of the report are related to a specific intuitive method of cognition, which was used in local history studies and had common features with the artistic method of a realist writer. Developing Dilthey’s philosophy of subjective cognition, Bely confronted the “scheme of conclusions”, the “summary of rules” as a feature of a degenerate civilization, with the singular and unique as a property of a developed culture. By introducing not an “industrial” but a “local history” essay into the title of his report, Bely reminded the audience of a recent discussion about the culture of a Marxist essay that unfolded on the pages of the RAPP magazine “Na literaturnom postu / On a Literary Post”. Voiced at a time of ideological and political respite, Bely’s report was the last attempt to institutionally assert the right to the existence of the methodology of local lore and a premonition of new trends in Soviet literary criticism of the first half of the 1930s.
Publishing House “Academia” in the Early 1930s: Race for Fees
Authors:   University of Lille, Rolet Serge
Published: April 2024

The memoirs of the staff of the publishing house “Academia” indicate that the activities of the publishing house were inspired by the disinterested love (illusio) of “authors” in the broadest sense (editors, translators, commentators, editors) for art and literature. Archival documents show that this is not the case. The very ambitious editorial policy that “Academia” demonstrates is largely declarative. In fact, the choice of published books is also and primarily associated with competition for copyright (lusio). The competition was quite open: the authors who manage to get the most regular and significant income from collaboration with the “Academia” are not necessarily the most influential politically. Competence, social flexibility, and tenacity enable seasoned professionals to steer publishing programs in a direction that is favorable to their personal interests. It is the competition between the authors, their sometimes long-standing closeness and the tactical nature of their behavior that make it possible to understand the sometimes paradoxical decisions of the editorial board. But the race for royalties is not a war of all against all. We see that the “Academia” has informal rules that are tacitly accepted by all employees (collusio). These rules, beneficial to all, ensure the survival of the “Academia” for several years in an alien and hostile environment of the Building of Socialism.
The Place of Shade
Authors: Anthony Morton  , Ray Franz
Published: April 2024

At first, the plan was simple — to be home by Christmas. To begin to view the very concept of home as built upon nostalgia. Imagining home is a pastime of any immigrant. If, as Breton suggests, ‘The imaginary is that which tends to become real,’ what were our imaginings bringing to life?

The Place of Shade is an artistic research inquiry into the contemporary wake of the Norwegian presence in South Africa. Norwegians began operating within the British colonial framework around 1840 — the same period as the migration to America. Lutheran missions, whaling, farming, business and family characterise this almost 200-year Afri-Norge diasporic heritage. It has been almost entirely overlooked in visual culture, until now. Their legacy remains an integral component of the city and the province's socio-cultural fabric to this day.

This exposition is just one expression within the broader scope of this ongoing project. Here, we on the one hand reflect on our preliminary research, methodology and fieldwork from a fictional standpoint — a kind of meta-methodological reflection — and, on the other hand, we address our Afri-Norge subject matter head-on. To achieve this, we narrate Ray Franz and Anthony Morton’s part in the initial fieldwork through the fictionalised perspectives of two PhD students at The University of Bergen — Vincent Dibble (RSA) and Bjarne Karlsen (NOR) — who leave their shared office to undertake an expedition which parallels ours, travelling to KwaZulu Natal, South Africa. This journey is set in the penumbra of the seismic socio-political events of 1999: The Truth and Reconciliation Commission, The South African Arms Deal, Case no. 4138/98, and the looming global spectre of Y2K. Dibble, an occidental eschatologist and accidental apocalypse-hunter. Bjarne, a philosophical cosmologist and photography enthusiast.

This exposition is imagined as the pair's pin board, suspended upon the expanse of their office wall upon returning to Norway. Behind them it hangs, a silent curation of fever dreams, as they weave theses into existence, their gaze drawn through the window onto the sprawling canvas of Bergen's cityscape.
REFLEXOS DA IMPRECISÃO DAS RECEITAS ORÇAMENTÁRIAS NOS GOVERNOS LOCAIS BRASILEIROS
Authors: Cabello Otávio Gomes , Azevedo Ricardo Rocha
Published: April 2024

Esta pesquisa objetivou analisar se municípios que apresentam maior acurácia de previsão orçamentária das receitas possuem menor endividamento e maior liquidez. Para tanto foram utilizados os dados orçamentários e financeiros dos municípios brasileiros de 2015 a 2019, cujos testes foram realizados pela estimação de regressão quantílica com dados em painel. Sendo assim, trata-se de uma pesquisa com finalidade aplicada, profundidade descritiva, caráter transversal e natureza quantitativa. Os resultados indicam que a superestimação da receita sugere um aumento do endividamento e a subestimação sugere uma redução do endividamento e aumento da liquidez nos municípios brasileiros. Os resultados contribuem para preenchimento de uma lacuna na literatura de finanças públicas, uma vez que se observou uma ausência em pesquisas que testassem empiricamente nos municípios brasileiros os reflexos da imprecisão orçamentária no endividamento e liquidez. Os resultados também contribuem para os gestores públicos municipais e aos órgãos de controle, como indicativo de que é necessária uma atenção aos modelos de previsão orçamentária das receitas, pois melhores estimações podem resultar em menor endividamento e maior liquidez.
Synthesis, antimycobacterial and antifungal evaluation of new 4-(furan-2-ylmethyl)-6-methylpyridazin-3(2H)-ones
Authors: Karayavuz Burcu , Vagolu Siva , Kart Didem , Tønjum Tone , Unsal-Tan Oya
Published: April 2024

This study reports the synthesis and evaluation of a series of new pyridazin-3-ones with furan moieties 5a?j and 6a?f, to test for their antimycobacterial and antifungal activities. The structures of the target compounds were confirmed by elemental analysis and spectroscopic techniques (IR, mass, 1H-and 13C-NMR). Amongst the compounds tested, 5e, 5g, 5i and 6e exhibited highest activity against Mycobacterium tuberculosis, while 5h, 6d and 6f showed moderate in vitro antifungal activities against Candida albicans and Candida parapsilosis.
Gordon Peter Wilson (1946–2020): Teacher, Mentor, Scholar, and Friend
Authors: Moehrle Stephen R. , Persson Martin E.
Published: April 2024

SYNOPSIS

G. Peter Wilson, most recently on the faculty at Boston College, was a consummate academic and leader. He profoundly influenced accounting research and the art and science of accounting instruction. He also advanced the accounting academy through his various leadership roles at the American Accounting Association. This memorial article documents Wilson’s early upbringing, academic career, professional activities, and achievements. The overarching themes are love and impact. Wilson loved life, loved his work, and above all, loved his family, friends, students, and colleagues. As a result, he profoundly impacted each aspect of the academy—research, teaching, and service. Indeed, his impact continues through the undergraduate and master students he inspired, the doctoral students he mentored at various universities and consortia, the colleagues he collaborated with, and the many who continue to learn from his innovations. This article sets forth the most significant impacts to preserve the past and inspire future generations.

JEL Classifications: M41; M42; M48.
Do Auditors View Off-the-Clock Misbehavior by Company Leadership as a Signal of Tone at the Top?
Authors: Christensen Brant E. , Cline Brandon N. , Lundstrom Nathan G. , Yore Adam S.
Published: April 2024

We study off-the-clock indiscretion accusations against corporate officers and directors and examine the extent, effectiveness, and context of auditors’ response. In the year that indiscretion allegations are first publicized, auditors charge higher fees and are more likely to resign. Auditors respond to allegations against both top executives and board members. Further, reactions are strongest when allegations demonstrate a lack of individual integrity and, separately, when the audit office has previously audited other similarly accused clients. Importantly, the resulting increase in auditors’ effort partially negates the association between indiscretions and lower financial reporting quality. However, auditors are primarily reactive, rather than proactive, and their response is stronger when the accused client is less important economically. These results suggest that company leadership’s off-the-clock indiscretions are signals to auditors of poor tone at the top, but the audit response is not uniform across all clients.

JEL Classifications: M41; M42; M48; G34.
PERBANDINGAN METODE KNN DAN SVM DALAM KLASIFIKASI KEMATANGAN BUAH MANGGA BERDASARKAN CITRA HSV DAN FITUR STATISTIK
Authors: Muchtar Mutmainnah , Muchtar Rafiqah Arjaliyah
Published: April 2024

This research compares the classification methods of K-Nearest Neighbors (KNN) and Support Vector Machine (SVM) in identifying the ripeness level of mango fruit based on HSV images and statistical features. A total of 80 mango fruit images were categorized into two classes, namely "ripe" and "unripe" mango, with 40 images each. Testing was conducted using k-cross validation, revealing that KNN achieved an accuracy of 98.75%, while SVM reached 97.5%. KNN demonstrated superior and consistent performance, indicating its effectiveness in mango fruit ripeness classification. The study contributes to the advancement of automated systems for mango fruit processing, leveraging image technology and machine learning to support the agriculture and food industry.
IMPLEMENTASI WAZUH MENGGUNAKAN METODE PPDIOO DI SISTEM KEAMANAN JARINGAN PSDKU UNIVERSITAS LAMPUNG WAYKANAN SEBAGAI DETEKSI DAN RESPON SERANGAN SIBER
Authors: Shafiyyah Azzah , Nama Gigih Forda , Pradipta Rio Ariestia
Published: April 2024

PSDKU Universitas Lampung Way Kanan membutuhkan sistem keamanan jaringan yang efektif untuk melindungi jaringan komputer server lab komputer dari serangan siber yaitu brute force dan Denial of Service (DoS)Untuk meningkatkan keamanan jaringan, diperlukan implementasi sistem keamanan jaringan dengan menggunakan platform wazuh sebagai server monitoring dan wazuh agent yang diinstal pada komputer server jaringan lab komputer PSDKU menggunakan Server Utama PSDKU. Metodepengembangan sistem keamanan yang digunakan yaitu PPDIOO (prepare, plan, design, implement, operate, optimize ) cisco. Dalam sistem ini, semuaaktivitas dari wazuh agent akan dikirimkan ke wazuh server untuk dilakukan pemantauan dan deteksi serangan siber. Kemudian dilakukan simulasi seranganbrute force dan Denial of Service (DoS) terhadap wazuh agent yang terinstal pada server jaringan lab komputer. Respon dari serangan bruteforce yang akan dilakukan adalah dengan memblokir alamat IP penyerang menggunakan software fail2ban dan serangan DoS dengan Active Response Wazuh sehingga penyerang tidak dapat mengakses dan tidak dapat terhubung ke komputer server jaringan lab komputer PSDKU. Sistem keamanan jaringan tidak dapatmendeteksi serangan DoS dengan jumlah rata-rata koneksi dibawah 4000 koneksi http, dan Serangan DoS berhasil dilakukan dengan hasil yang menunjukkan bahwa Server Utama PSDKU memiliki ketahanan dalammenerima dan melayani koneksi HTTP dibawah 3.522.013 koneksi. Sehinggasistem keamanan jaringan dapat ditingkatkan dan respon terhadap serangan siber dapat dilakukan secara cepat dan efektif.
ANALISIS KEPUASAN PENGGUNA TERHADAP APLIKASI REDBUS DENGAN MENGGUNAKAN METODE END USER COMPUTING SATISFACTION (EUCS)
Authors: Pramudibyo Nandya
Published: April 2024

Abstrak. Aplikasi Redbus adalah aplikasi agen perjalanan berbasis online atau yang dapat disebut Online Travel Agent (OTA). Aplikasi ini memiliki fitur layanan seperti tiket pemesanan tiket transportasi Bus dan Shuttle yang dapat membantu pengguna berpergian ke suatu tempat dan pastinya untuk menambah kepuasan pelanggan pada Redbus. Model kepuasan pengguna yang digunakan adalah End User Computing Satisfaction dengan 5 variabel yaitu content, accuracy, format ease of use dan timeliness. Hasil pengujian validitas dan reliabilitas dinyatakan valid dan reliable. Hasil pengujian linearitas dan normalitas dinyatakan normal. Penilaian menggunakan skala likert, pengolahan data menggunakan SPSS versi 26 dan pengujian hipotesis menggunakan regresi linear berganda (uji F dan uji T). ). Terdapat pengaruh secara simultan dari hasil penelitian berdasarkan pengujian hipotesis (Uji F) yang memiliki pengaruh positif terhadap kepuasan pengguna aplikasi Redbus karena berpengaruh besar pada kualitas aplikasi terhadap kepuasan pengguna sebesar 79.034. Terdapat pengaruh yang tidak signifikan antara variabel bebas (accuracy dan user satisfaction) secara individual (parsial). Terdapat pengaruh yang tidak signifikan antara variabel bebas (format dan user satisfaction) secara individual (parsial). Terdapat pengaruh secara signifikan antara variabel bebas (ease of use dan user satisfaction) secara individual (parsial). Terdapat pengaruh secara signifikan antara variabel bebas (timeliness dan user satisfaction) secara individual (parsial).
IMPLEMENTASI KLASIFIKASI SENJATA TRADISIONAL JAWA BARAT MENGGUNAKAN CONVOLUTIONAL NEURAL NETWORK (CNN) DENGAN METODE TRANSFER LEARNING
Authors: Karim Ryas Rafi
Published: April 2024

Studi ini membahas implementasi Convolutional Neural Network (CNN) dengan metode Transfer Learning untuk klasifikasi senjata tradisional Jawa Barat menggunakan EfficientNetB0. Dataset terbatas yang terdiri dari 754 gambar senjata tradisional dibagi menjadi train, validation, dan test set. Pengujian dilakukan dengan 75 epoch dan batch size 16. Hasil menunjukkan peningkatan konsisten dalam performa model, meskipun akurasi validasi tidak melampaui 0.9794. Evaluasi model mencapai akurasi 98,44%, dengan nilai loss rendah. Laporan klasifikasi menunjukkan kekurangan pada kelas gacok, sementara kelas lainnya seperti arit, bedog, dan kujang memiliki performa baik. Meskipun keterbatasan dataset, model ini berhasil dan dapat menjadi dasar untuk penelitian lebih lanjut dalam pengenalan senjata tradisional Jawa Barat.This study discusses the implementation of Convolutional Neural Network (CNN) with the Transfer Learning method for classifying traditional weapons in West Java using EfficientNetB0. A limited dataset consisting of 754 images of traditional weapons is divided into train, validation, and test sets. Testing was carried out with 75 epochs and batch size 16. Results showed consistent improvements in model performance, although validation accuracy did not exceed 0.9794. The model evaluation achieved an accuracy of 98.44%, with a low loss value. The classification report shows deficiencies in the gacok class, while other classes such as sickles, bedogs and cleavers have good performance. Despite the limitations of the dataset, this model is successful and can be a basis for further research in the introduction of West Javanese traditional weapons.
THE RELATIONSHIP BETWEEN PUBLIC INFORMATION OPENNESS AND ICT DEVELOPMENT
Authors: Al Azies Harun , Dikaputra Ishak Bintang
Published: April 2024

The relationship between Information and Communication Technology (ICT) development and the level of Public Information Openness (KIP) holds significant implications for inclusive and sustainable societal development. This study employs statistical analysis, including Pearson correlation, to examine this relationship across Indonesian provinces in 2022. Findings indicate a positive correlation between ICT development and KIP. Access to ICT infrastructure and ICT usage show significant correlations with IKIP levels across various provinces. Provinces with better ICT development generally exhibit higher KIP levels. However, the relationship with ICT skills is comparatively weaker, indicating other influencing factors on ICT literacy within the community. The conclusion drawn from this research is that ICT development positively contributes to enhancing Public Information Transparency in Indonesia. Therefore, further efforts are needed to support equitable ICT development, enhance digital literacy, and strengthen public information transparency, enabling the population to effectively harness information and communication technology