bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS DENSITAS Emerita emeritus TERHADAP TEKSTUR DAN BAHAN ORGANIK SEDIMEN DI PANTAI GLAGAH, KULON PROGO, YOGYAKARTA
Authors: Nirmala Intan Via , Sulardiono Bambang , Hartoko Agus
Published: May 2023

Di Indonesia, undur-undur laut famili Hippidae terdistribusi dengan baik di sepanjang Pantai Selatan Jawa, khususnya Pantai Glagah. Pantai Glagah merupakan pantai berpasir hitam yang menjadi daerah obyek wisata dan terdapat budidaya udang di sekitarnya. Emerita meritus merupakan undur-undur laut yang paling sering ditemui dan mempunyai kepadatan tertinggi. Biota ini ditangkap oleh nelayan untuk dijual dan dikonsumsi. Penelitian dilaksanakan pada bulan April 2019. Penelitian ini bertujuan untuk menganlisis densitas, tekstur sedimen, bahan organik, dan aspek biologi, serta korelasinya antara densitas, panjang karapas dan berat Emerita emeritus dengan tekstur sedimen dan bahan organik di Pantai Glagah, Kulon Progo, Yogyakarta. Pengolahan data dengan menggunakan program Microsoft Excel dan SPSS 16. Total sampel sebanyak 305 individu yaitu 29 individu/m2 (Glagah Timur 1), 43 individu/m2  (Glagah Timur 2), 65 individu/m2  (Glagah Timur 3), 74 individu /m2 (Glagah Barat 3), 53 individu/m2  (Glagah Barat 2), dan 44 individu/m2 (Glagah Barat 1). Tekstur sedimen paling dominan adalah pasir halus (0,125-0,25 mm). Nilai Bahan Organik dari Glagah Timur dan Barat semuanya sebesar nol. Pola pertumbuhan Emerita emeritus betina (total) adalah alometrik negatif (pertumbuhan panjang lebih cepat dibandingkan dengan pertumbuhan bobotnya). Nilai faktor kondisi Emerita emeritus betina (total) sebesar 1,242. Hubungan densitas Emerita emeritus dengan tekstur sedimen memiliki korelasi yang cukup erat. Hubungan antara panjang karapas dan berat Emerita emeritus dengan tekstur sedimen memiliki korelasi yang rendah.
PENGARUH TOTAL SUSPENDED SOLID (TSS) TERHADAP DENSITAS Zooxhanthellae PADA KARANG Acropora sp. DALAM SKALA LABORATORIUM
Authors: Rizka Raema Farah , Purnomo Pujiono Wahyu , Sabdaningsih Aninditia
Published: May 2023

Sedimentasi merupakan faktor utama yang mengakibatkan kematian karang. Konsentrasi TSS yang tinggi cenderung menyebabkan sedimentasi yang tinggi. Pengaruh TSS pada perairan menyebabkan cahaya yang masuk kedalam perairan terhambat, sehingga dapat menurunkan aktivitas fotosintesis pada zooxanthellae. Sedimen yang terdeposit juga akan menutupi permukaan polip karang sehingga akan meningkatkan kebutuhan energy metabolic untuk menghilangkannya kembali. Tujuan penelitian untuk mengetahui pengaruh TSS terhadap densitas zooxanthellae dan hubungannya dengan fotosintesis dan respirasi. Penelitian dilaksanakan pada bulan November-Desember 2019, di Laboratorium Pengembangan Wilayah Pantai Jepara Undip. Metode yang digunakan adalah metode experimental. Spesimen yang digunakan adalah karang Acropora sp. Sampel karang Acropora sp. diambil dari perairan Pulau Panjang Jepara. Perlakuan pada penelitian ini adalah dengan memberikan konsentrasi TSS 10 mg/L; 30 mg/L dan 50 mg/L yang dilarutkan pada media pemeliharaan. Pengamatan dilakukan pada interval waktu ke- 0, 4, 8 dan 12 hari. Parameter utama yang diamati adalah densitas zooxanthellae, fotosintesis dan respirasi serta pendukung yaitu kualitas air. Hasil penelitian menunjukan bahwa perlakuan dengan konsentrasi TSS 50 mg/L menyebabkan penurunan densitas zooxanthellae yang paling tinggi. Berdasarkan Analisis Regresi Linear Sederhana pada konsentrasi TSS 50 mg/L diperoleh persamaan regresi Y= -285.477 X + 6E+06. Kelimpahan zooxanthellae mempengaruhi nilai fotosintesis dan respirasi. Semakin sedikit kelimpahan zooxanthellae maka nilai fotosintesis yang dihasilkan menurun, sebaliknya nilai respirasi semakin tinggi.
KADAR LOGAM BERAT Pb, Fe, DAN Cd YANG TERKANDUNG DALAM JARINGAN LUNAK KERANG BATIK (Paphia undulata) DARI PERAIRAN TAMBAK LOROK, SEMARANG
Authors: Prihati Sri Rahayu , Suprapto Djoko , Rudiyanti Siti
Published: May 2023

Perairan Tambak Lorok, Semarang yang terletak di pantai utara Jawa, dikelilingi berbagai industri, PLTU PT Indonesia Power, Pelabuhan Tanjung Mas dan pemukiman sehingga berpotensi tercemar berbagai jenis limbah, salah satunya yaitu logam berat. Logam berat dapat terakumulasi oleh organisme perairan, diantaranya adalah kerang batik (Paphia undulata) yang bersifat filter feeder dan banyak terdapat di Perairan Tambak Lorok. Hal ini menjadi alasan penelitian mengenai kandungan logam berat Pb, Fe, dan Cd pada jaringan lunak kerang batik di Perairan Tambak Lorok dilaksanakan. Penelitian ini bertujuan untuk mengetahui kandungan logam berat Pb, Fe, dan Cd pada perairan Tambak Lorok dan jaringan lunak kerang batik, serta mengetahui batas konsumsi mingguan kerang batik dari perairan tersebut. Metode yang digunakan adalah studi kasus dengan analisis deskriptif kualitatif, penentuan lokasi sampling dilakukan secara purposive. Penelitian dilakukan pada bulan Mei 2019. Hasil penelitian menunjukkan kadar logam berat Pb, Fe, dan Cd di perairan Tambak Lorok berturut-turut 0,723; 8,261; dan 2,482 mg/l telah melebihi batas layak menurut KepMen LH No.51 tahun 2004 tentang baku mutu air laut untuk biota laut, sedangkan pada jaringan lunak kerang batik berturut-turut adalah 5,47; 299,909; dan 32,423 mg/kg telah melebihi baku mutu logam dalam pangan khusus bivalvia menurut SNI 7387 tahun 2009. Batas maksimum konsumsi mingguan kerang batik yang mengandung logam berat Pb, Fe dan Cd dari perairan Tambak Lorok untuk individu dengan berat badan 20 kg, 50 kg dan 65 kg berturut-turut yaitu 4; 11; dan 14 gram/minggu.
ANALISIS TOTAL BAKTERI Aeromonas sp. PADA IKAN NILA (Oreochromis niloticus) DI WILAYAH KERAMBA JARING APUNG (KJA) DAN NON-KJA RAWA PENING
Authors: Pusparani Rusenda , Widyorini Niniek , Jati Oktavianto Eko
Published: May 2023

Rawa Pening merupakan ekosistem danau yang terdapat di Kabupaten Semarang. Banyaknya kegiatan seperti budidaya, pertanian, dan pariwisata menyebabkan peningkatan kandungan bahan organik dan pencemaran perairan. Menurunnya kualitas perairan dapat menyebabkan adanya bakteri patogen yang dapat mempengaruhi kehidupan ikan di perairan. Penelitian ini bertujuan untuk mengetahui total bakteri Aeromonas sp. pada ikan dan mengetahui perbedaan total kelimpahan bakteri Aeromonas sp.  pada ikan di wilayah KJA dan non-KJA Rawa Pening. Kegiatan penelitian telah dilaksanakan pada bulan Februari – Mei 2020 di Rawa Pening, Kabupaten Semarang dan analisis bakteri Aeromonas sp. dilakukan di Laboratorium Pengelolaan Sumberdaya Ikan dan Lingkungan (PSDIL), Fakultas Perikanan dan Ilmu Kelautan, Universitas Diponegoro. Materi yang digunakan dalam penelitian ini adalah sampel ikan nila yang diperoleh dari KJA dan non-KJA di Rawa Pening Kabupaten Semarang sesuai dengan titik koordinat pengambilan sampel ditentukan dengan menggunakan GPS dan dilakukan secara temporal sebanyak 2 kali dengan rentang waktu 1 minggu. Variabel yang diukur adalah pH, DO (Dissolved Oxygen), temperatur perairan dan udara, serta analisis total kelimpahan bakteri Aeromonas sp.  Analisis statistik menggunakan uji Normalitas dilanjutkan dengan uji Anova. Hasil kelimpahan rata-rata Aeromonas sp. pada ikan di wilayah KJA adalah 5,0 x 105 CFU/mL dan pada wilayah Non-KJA yaitu 6,9 x 105 CFU/mL. Total bakteri pada ikan di wilayah KJA berkisar 2,29 x 106 – 1,12 x 106 CFU/mL. Analisis diperoleh nilai signifikan 0,414 > 0,05. Tidak terdapat perbedaan signifikan pada total bakteri yang diduga Aeromonas sp. pada ikan nila di wilayah KJA dan Non-KJA.
ANALISIS PERBEDAAN KELIMPAHAN BAKTERI HETEROTROF DENGAN KANDUNGAN BAHAN ORGANIK PADA SEDIMEN DI EKOSISTEM MANGROVE TRIMULYO, KECAMATAN GENUK, KOTA SEMARANG
Authors: Putri Rizki Riza , Widyorini Niniek , Jati Oktavianto Eko
Published: May 2023

Ekosistem mangrove menghasilkan serasah yang dapat dimanfaatkan sebagai sumber nutrien untuk bakteri heterotrof. Serasah didekomposisi oleh bakteri heterotrof yang mampu mendegradasi bahan organik menjadi bahan anorganik. Tujuan dari penelitian yakni mengetahui kelimpahan bakteri heterotrof serta hubungannya dengan kandungan bahan organik pada ekosistem mangrove dan sekitarnya. Penelitian ini dilaksanakan pada Januari sampai mei 2020 di ekosistem mangrove Trimulyo, Kecamatan Genuk, Kota Semarang. Analisis kelimpahan bakteri heterotrof dilaksanakan di Laboratorium Pengelolaan Sumberdaya Ikan dan Lingkungan, Fakultas Perikanan dan Ilmu Kelautan. Analisis bahan organik dilaksanakan di Laboratorium Ekologi dan Produksi Tanaman, Fakultas Peternakan dan Pertanian, Universitas Diponegoro, Semarang. Metode penelitian yang digunakan adalah metode deskriptif. Penentuan lokasi sampling menggunakan metode purposive sampling. Pengambilan sampel penelitian diambil di ekosistem mangrove dan sekitarnya. Penanaman bakteri dilakukan menggunakan metode (spread plate), perhitungan kelimpahan bakteri menggunakan metode Total Plate Count (TPC). Analisis data menggunakan T-test dan Regresi. Rata-rata kelimpahan bakteri heterotrof di sedimen yang diperoleh yaitu 5,24x107 - 1,32x108 CFU/mL, sedangkan di air 1,39x105 - 6,37 x105 CFU/mL. Hasil bahan organik sedimen yaitu 4,32 – 14,71%. Kesimpulan dari penelitian ini menunjukkan adanya perbedaan antara kelimpahan bakteri heterotrof di sedimen dan air (p < 0,05). Hubungan antara kelimpahan bakteri heterotrof di sedimen dengan bahan organik memiliki hasil (r=0,693) yang artinya berkorelasi sedang.
HUBUNGAN KANDUNGAN NITRAT DAN FOSFAT DENGAN KELIMPAHAN FITOPLANKTON DI PERAIRAN DESA TIMBULSLOKO, KABUPATEN DEMAK
Authors: Napitupulu Rijon , Muskananfola Max Rudolf , Sulardiono Bambang
Published: May 2023

Desa Timbulsloko merupakan kawasan pesisir di Kabupaten Demak yang sebagian besar wilayahnya adalah daerah bekas tambak dan ekosistem mangrove yang telah mengalami degradasi. Ekosistem mangrove merupakan ekosistem yang sangat khas dan sensitif terhadap perubahan lingkungan. Selain vegetasi mangrove, ekosistem mangrove tersusun atas spesies unik dari jenis plankton, ikan maupun invertebrata lain. Fitoplankton berfungsi sebagai produsen utama (produsen primer dalam rantai makanan), sumber oksigen dalam perairan dan dapat digunakan sebagai indikator lingkungan. Penelitian ini dilaksanakan pada bulan Maret 2019. Tujuan dari penelitian ini adalah untuk mengetahui kelimpahan fitoplankton, kandungan nitrat dan fosfat, serta hubungan kandungan nitrat dan fosfat dengan kelimpahan fitoplankton. Hasil penelitian menunjukkan kelimpahan fitoplankton saat pasang dan surut berkisar antara 13365-18270 ind/L. Jumlah fitoplankton yang teridentifikasi terdiri dari 17 genera dari 4 kelas yaitu Bacillariophyceae, Chlorophyceae, Cyanophyceae, dan Dinophyceae. Konsentrasi nitrat berkisar antara 0,047-1,025 mg/L saat pasang dan 0,028-0,310 mg/L saat surut. Konsentrasi fosfat berkisar antara 0,030 mg/L-0,164 mg/L saat pasang dan 0,015-0,133 mg/L saat surut. Hasil uji regresi linier berganda menunjukkan bahwa terdapat hubungan yang lemah antara kandungan nitrat dan fosfat terhadap kelimpahan fitoplankton.
KEBIASAAN MAKANAN DAN LUAS RELUNG IKAN RED DEVIL (Amphilophus labiatus) DI PERAIRAN WADUK JATIBARANG, SEMARANG
Authors: Isroliyah Afifatul , Solichin Anhar , Rudiyanti Siti
Published: May 2023

Waduk Jatibarang dimanfaatkan sebagai daerah pengendali banjir, daerah pariwisata dan konservasi ikan air tawar. Jenis ikan yang terdapat di Waduk Jatibarang antara lain ikan Nila, Grass Carp, Gabus, Bader/Tawes, Bandeng, dan Red Devil. Penelitian ini bertujuan untuk mengetahui kebiasaan makanan ikan Red Devil (Amphilophus labiatus), sehingga dapat dijadikan rujukan pengelolaan di Waduk Jatibarang agar populasi ikan tetap terjaga kelestarianya. Penelitian ini dilakukan dengan mengambil sampel ikan Red Devil (Amphilophus labiatus) di perairan Waduk Jatibarang dengan menggunakan alat tangkap Buttom Gillnet, Surface Gillnet, dan alat tangkap pancing. Pengambilan sampel dilakukan sebanyak 2 kali yaitu pada bulan Juli dan bulan November 2020. Perairan Waduk Jatibarang memiliki total  kelimpahan plankton sebesar 4360 ind/L dengan kelimpahan terbanyak pada kelas Chlorophyceae dengan nilai kelimpahan sebesar 1780 ind/L dan persentase 40,83%. Hasil penelitian menunjukkan bahwa Chlorophycea merupakan makanan utama bagi ikan Red Devil dimana nilai IP adalah 65,01%, sedangkan kelas Cyanopyceae dan Bacillariophyceae adalah makanan pelengkap, dan kelas Coscinodiscophyceae, Dinophyceae, Euglenoidea, Fragilariophyceae, Mediophyceae, Zygnematophyceae, serta Zooplankton merupakan makanan tambahan. Berdasarkan hasil indeks pilihan makanan diketahui bahwa ikan Red Devil memilih makanan dari kelas Chlorophycea,  Coscinodiscophyceae, Cyanopyceae, dan Zygnematophyceae. Luas relung ikan tawes adalah 2.038 dengan Pi terbesar berasal dari plankton Chlorophyceae sebesar 0,061 sedangkan Pi terkecil dari kelas Mediophyceae yang bernilai 0.
PENGARUH KONDISI TERUMBU KARANG DENGAN STRUKTUR KOMUNITAS IKAN KARANG DI PULAU KARIMUNJAWA DAN PULAU KEMUJAN, JEPARA, JAWA TENGAH
Authors: Rahman Muhammad Arkan Zaky , Afiati Norma , Purnomo Pujiono Wahyu
Published: May 2023

Pulau Karimunjawa dan Pulau Kemujan merupakan Kawasan dalam Taman Nasional Karimunjawa (TNKJ) yang memiliki ekosistem terumbu karang berupa reef flat dan reef slope. Kedua pulau ini seringkali dikunjungi wisatawan, sehingga aktivitas tersebut diperkirakan mempengaruhi kualitas perairannya. Penurunan kualitas perairan menyebabkan perubahan struktur komunitas biota, dalam studi ini ikan karang dan terumbu karang. Berdasarkan alur pemikiran tersebut, maka dilakukan penelitian dengan tujuan mengetahui keanekaragaman, kelimpahan serta hubungan ikan karang dan terumbu karang pada daerah reef flat dan reed slope. Pengambilan data dilaksanakan pada bulan Agustus tahun 2020 di perairan Pulau Karimunjawa (Tanjung Gelam dan Legon Lele) dan Pulau Kemujan (Pulau Sintok dan Batulawang), Kabupaten Jepara, Jawa Tengah. Pengamatan terumbu karang dilakukan dengan menggunakan metode UPT (Underwater Photo Transect) kemudian data diolah menggunakan aplikasi CPCE (Coral Point Count with Excel). Pengamatan ikan karang dilakukan menggunakan metode UVC (Underwater Visual Census). Hasil menunjukkan bahwa kelimpahan karang hidup di lokasi penelitian termasuk kategori sedang hingga sangat baik (24%-77,89%). Indeks keanekaragaman tertinggi terumbu karang ditemukan di Pulau Sintok (2,322) dan terendah di Legon Lele (1,815). Indeks keanekaagaman dan kelimpahan ikan karang tertinggi ditemukan di Pulau Sintok (H’ = 3,254 dan 500 ind/150m2) dengan dominasi famili Pomacentridae, sedangkan terendah ditemukan di Tanjung Gelam (H’ = 2,372 dan 123 ind/150m2). Kelimpahan ikan karang dipengaruhi oleh kondisi terumbu karang sebesar 95,83% (R2 = 0,9583). Semakin baik kondisi terumbu karang, maka semakin tinggi kelimpahan ikannya. Hasil uji anova menunjukkan nilai F hitung = 54,498 dengan tingkat signifikasi sebesar 0,0034 (α<0,05). Hal ini menunjukkan bahwa data signifikan dan hipotesis diterima.
ANALISIS STATUS MUTU AIR DAN BEBAN PENCEMARAN SUNGAI SIANGKER, SEMARANG
Authors: Fibriani Septina , Haeruddin Haeruddin , Ayuningrum Diah
Published: May 2023

Sungai Siangker merupakan sungai yang terletak di Semarang Barat yang di sekitarnya terdapat kawasan perumahan Puri Anjasmoro, rumah makan dan tambak yang mana buangan limbah dari berbagai kegiatan tersebut langsung dialirkan ke sungai yang dapat menyebabkan penurunan kualitas perairan. Tujuan penelitian ini untuk mengetahui konsentrasi, status mutu air dan kesesuaian daya dukung kualitas air berdasarkan variabel BOD, COD, dan total coliform di Sungai Siangker. Penelitian dilaksanakan pada bulan Januari – Februari 2021. Metode yang digunakan dalam penelitian ini adalah metode survei dan teknik purposive sampling dengan penentuan titik berdasarkan sumber cemaran. Pengambilan sampel dilakukan pada 4 titik dengan 3 kali pengulangan. Kualitas air yang diuji secara in situ meliputi suhu, pH, debit sungai, dan DO, sedangkan pengukuran ex situ meliputi BOD, COD, dan total coliform yang diuji di Balai Laboratorium Kesehatan dan Pengujian Alat Kesehatan, Semarang. Hasil penelitian menunjukkan rata-rata konsentrasi BOD, COD, dan total coliform dalam 4 titik masing-masing sebesar 7,63 mg/l, 21,6 mg/l, 4861,67 MPN/100 ml. Beban pencemaran BOD, COD dan total coliform dari titik I sampai titik IV rata-rata masing-masing sebesar 548,54 kg/hari, 1688,27 kg/hari, 33,23 x 1011 MPN/hari. Konsentrasi beban pencemaran BOD dan COD diketahui telah melampaui kapasitas asimilasi sungai. Konsentrasi kapasitas asimilasi BOD sebesar 245,598 kg/hari dan COD sebesar 2.091,65 kg/hari. Status mutu air Sungai Siangker termasuk ke dalam kategori tercemar ringan dengan rata-rata nilai Indeks Pencemaran sebesar 3,04.
ANALISIS KONSENTRASI LOGAM BERAT Pb, Cd DAN KESADAHAN DI PERAIRAN SUB DAERAH ALIRAN SUNGAI (DAS) GARANG, SEMARANG
Authors: Rizkiyah Mayang , Rudiyanti Siti , Rahman Arif
Published: May 2023

The Garang Sub-watershed consists of a reservoir and some river that flows from its upstream to downstream. The changes in water quality that occur upstream will affect the downstream. Garang watershed’s condition is easily contaminated, especially from element Lead (Pb) and Cadmium (Cd). This condition is caused by human activities that can impact the watershed’s water quality. The purpose of this research is to find out Pb’s concentration, Cd’s concentration and its comparison with quality standards, the difference between Pb’s concentration and Cd’s concentration at Garang Sub-watershed’s upstream, Jatibarang Reservoir and Garang Sub-watershed’s downstream, and the correlation of Pb’s concentration and Cd’s concentration to the water hardness as one of the factors that affect heavy metals.The method of this research is surevy method with quantitative descriptive analysis method. The sampling was conducted in 13 stations in September 2020 stations 1-3 were upstream, stations 4-10 were reservoirs and stations 11-13 were downstream. The highest Pb’s concentration was 0,52 mg/l at the 13th station, and the lowest Pb’s concentration was 0,252 mg/l at the 7th station. The highest Cd concentration was 0,116 mg/l at the 1st station and 3rd station, and the lowest Cd concentration was 0,058 mg/l at the 4th station. Based on the regulation (PP. No. 82, 2001), the concentration of heavy metals exceeds the water quality standards (Pb > 0,03 mg/l and Cd > 0,01 mg/l). There is no difference between Pb and Cd concentrations at the upstream, Jatibarang reservoir, and downstream (Sig.>0.05). There are a correlation of heavy metal Pb’s concentration and Cd’s concentration with the water hardness shows a very low correlation, Pb (r = 0.146) and Cd (r = 0.085).
Kepadatan dan Tempat Potensial Perindukan Larva Aedes spp. di Tempat-tempat Umum di Kecamatan Mijen Kota Semarang
Authors: Dheandri Agnes Ajeung , Yuliawati Sri , Hestiningsih Retno , Martini Martini , Jayanti Siswi
Published: May 2023

Semarang city is one of the endemic areas of DHF disease in Central Java Province. Mijen District is the endemic area of DHF in Semarang City, with a spike in cases in 2020. One of the potential places of transmission of DHF is public places where people gather from various regions, so this place is at high risk of DHF transmission. The purpose of this study was to find out the density and potential place of the Aedes sp larvae. in public places Mijen District semarang city. The method used is observational analytics with cross sectional research design. The larva survey method uses the single larva method.  The sample of this study is 100 public places. The results of this study were mostly larvae found to be Aedes aegypti 30 (55.6%) and Aedes albopictus 24 (44.4%), the type of public places most larvae found was restaurant and bus station. Density of larvae Aedes sp. based on HI 54%, CI 26.47%, BI 63% so that density figure is in category 6-9 which means that the density of larvae is classified as high with a high risk of transmission of DHF disease caused by vectors. The larva-free index of 46% shows that it is still well below the national standard of ≥95%. The density of mosquito larvae should be controlled by conducting regular larval inspection by the janitor at the pulic places.
Analisis Manajemen Keselamatan dan Kesehatan Kerja pada Keadaan Darurat Kebakaran di Mass Rapid Transit (MRT) Jakarta
Authors: Satrio Judea , Lestantyo Daru , Wahyuni Ida
Published: May 2023

The Jakarta Mass Rapid Transit (MRT) is an urban mass and fast transit transportation system based on electric rail, which is characterized by its ability to carry large volumes of passengers quickly. In its operational service activities, the Jakarta MRT can experience a fire emergency situation. Therefore, a fire emergency response system is needed as an effort of occupational safety and health management in preventing and overcoming fire emergency situations that may occur. This study aims to analyze the fire emergency response system in the Jakarta MRT. This type of research is a descriptive study with a qualitative approach. The data were collected through direct observation and organized online in-depth interviews involving 4 main informants and 2 triangulation informants. The result of this study shows that the Jakarta MRT has a fire emergency response system that includes the fire emergency response policy, fire hazard identification, emergency response team, fire protection systems, life-saving facilities, fire emergency response training, emergency communications, fire safety inspection, fire emergency response procedure, investigation and report, and fire safety audit. However, there are still fire protection systems at the station and in the train that are not available and not in accordance with the applicable standards such as the fire control center, fire elevator, yard hydrant, sprinklers, fire extinguishers, smoke control system, firefighter access, and emergency safety hammer. The researcher suggests the Jakarta MRT provide fire protection systems that are not yet available and adjust the fire protection systems in accordance with applicable standards of laws and regulations.
Analisis Ketidaksesuaian Penerapan Sistem Manajemen Keselamatan dan Kesehatan Kerja (SMK3) di Isntitusi Pendidikan X Berdasarkan Hasil Audit SMK3
Authors: Ayunita Dwi Retno , Kurniawan Bima , Widjasena Baju
Published: May 2023

Educational institutions are workplaces that can’t be separated from the risk of harm due to activities carried out by lecturers, employees, and / or laboratory officers in it. Occupational safety and health are implemented with the aim of reducing the risk of harm and increasing the productivity of teaching and learning activities. Therefore, this study aimed to analyze the discrepancy in the application of occupational safety and health management system (SMK3) based on the results of SMK3 audits in educational institutions X. This research was a type of qualitative research with analytical observational design that used an in-depth interview approach. The method of data retrieval was conducted through in-depth interviews with 4 informants as well as using secondary data. The results showed that the level of application of SMK3 in educational institutions X has been obtaining of gold certificate of SMK3 audit results in accordance with PP 50 of 2012 in the initial level category. While some of the things that caused the finding in clauses 1.2.2, 1.2.5, and 1.4.3 which were minor categories because educational institution X has not conducted training and certification for the person in charge of the designated K3 experts and also the designated emergency officers, as well as the lack of communication with the relevant agencies related to the P2K3 enforcement decree. Overall, the cause of the findings were due to workplace inconsistencies in fulfilling the implementation of SMK3. Therefore, awareness is needed related to K3’s commitment to top management so that the existing regulations in the workplace support the fulfillment of K3 regulations.
Faktor yang Berhubungan dengan Kejadian Demam Berdarah Dengue (DBD) di Daerah Endemis Tinggi Kota Semarang
Authors: Zulfa Afifah Afanin , Martini Martini , Udijono Ari , Hestiningsih Retno , Jayanti Siswi
Published: May 2023

Abstrak:  Dengue hemorrhagic fever is a mosquito-borne transmitted disease which prevention is through 1 Jumantik 1 Home movement (1J1HM). 1J1HM is a program which included the activity of preventing Dengue Hemorrhagic Fever (DHF), called Mosquito Nest Eradication (PSN 3M Plus). The purpose of this study is to describe the actions in the implementation of 1J1HM and to find the factors correlate with the numbers of DHF case in the Sendangmulyo Village. The type of the research is descriptive observational, quantitative data with a cross-sectional approach. With 100 residents of Sendangmulyo Village as the sample,  using the sampling methode of purposive sampling. Data analysis used is chi-square test. The result shows that the number of respondents implementing 1J1HM in Sendangmulyo Village is only 35%. The result means not half of the samples are implementing the action of 1J1HM.  Bivariate analysis showed that there are correlations between the level of knowledge (p=0.012) POR 3.9 (CI 1.29-11.9) and attitude (p=0.000) POR 16.5 (CI 6.38-42.6) with the actions in 1J1HM in Kelurahan Sendangmulyo. And there are no correlations between age and education level with the action of 1J1HM. It is hoped that residents in Sendangmulyo village would be have better environmental hygiene and health, better understanding and increased in information.
Pola Perilaku Pencegahan KTD dan Penularan IMS pada Anak Jalanan di Kota Semarang
Authors: Shofa Ikhwanush , Shaluhiyah Zahroh , Husodo Besar Tirto , Musthofa Syamsulhuda Budi
Published: May 2023

Street children are children under the age of 18 who spend most of their time living on the streets or other public places. The lack of supervision and education of street children, especially at the age of teenagers, makes street children have a high risk of premarital sex. Premarital sex is a major risk factor for unwanted pregnancies and the transmission of sexually transmitted infections. This study aims to determine how the behavior of street children in the city of Semarang in avoiding the impact of premarital sex behavior. This study uses a descriptive method with a qualitative approach with the technique of taking research subjects using a questionnaire. The research subjects were 2 street children who were female and had had premarital sex. Triangulation research subjects were 2 people who were parents and caregivers of the research subjects. The research data was taken by in-depth interview technique. The results showed that the behavior of Unwanted Pregancies and STI prevention of research subjects was still poor. Both study subjects had experienced unwanted pregnancies. They never seek information about the impact of premarital sex and how to prevent it. They also never had a health professional consultation with health workers. To prevent contracting STIs, they are only being careful in choosing sex partner, choosing to be loyal to their boyfriend, or using condoms. To prevent pregnancy they use condoms or, preferably, interrupted intercourse. Unfortunately, these prevention technique was not carried out properly, causing the research subjects to experience unwanted pregnancies.
Gambaran Kesehatan Mental Pada Tenaga Kesehatan Kantor Kesehatan Pelabuhan Di Masa Pandemi Coronavirus Disease-19 (COVID-19) Tahun 2021
Authors: Ginanjar Sutan Harya , Udijono Ari , Kusariana Nissa , Sutiningsih Dwi
Published: May 2023

The increase of COVID-19 cases in Indonesia is in line with the increasing duties of health workers at the point of entry of the country. The task of handling COVID-19 provides psychological pressure and potential to cause depression, stress, and anxiety problems for health workers. This type of research was analytic observational with a cross-sectional design. Data collection was collected by online survey on May to August 2021. The Number of sample in this study was 350 health workers at Health Quarantine Offices in Indonesia. The mental health data collection instrument used DASS-21 questionnaire to check the level of depression, stress, and anxiety. The result showed that there was health workers with moderate to very severe depression in Health Quarantine Offices were 104 respondents (29,7%). The level of anxiety of health workers with moderate to very severe category was 146 respondents (41.7%). Meanwhile, the stress level of health workers with moderate to very severe category was 79 respondents (22,6%). The researcher concludes that the identification of data about the level of depression, anxiety, and stress in health workers at the Quarantine Health Office was needed as an effort to prevent of mental health disorders in health workers. Joint collaborative actions can be pursued by various parties, especially in providing interventions to deal with mental health problems for health workers during the COVID-19 pandemic.
Gambaran Pengelolaan Limbah Masker Sekali Pakai oleh Rumah Tangga pada Masyarakat di Kota Semarang
Authors: Lubriyana Triyani , Nurjazuli Nurjazuli , Dewanti Nikie Astorina Yunita
Published: May 2023

The production of mask waste in the public of Semarang city reaches 1.2 kg per day. Mask waste is an infectious waste that requires proper management. The purpose of this study was to determine the knowledge, accessibility of information, and the practice of managing the waste of disposable masks by households in the community of Semarang city. This study is an observational analytic study with a cross-sectional design. Data collected using an online questionnaire survey. The sample in this study was 130 respondents aged 15-64 years who resided and domiciled in Semarang city. Data analysis used univariate and bivariate analysis with chi-square test statistical test. In this study, the results of univariate analysis were obtained, namely the majority of respondents had good knowledge of 52.3% of respondents, good information accessibility of 66.9% of respondents, and good practice of 54.6% of respondents. The results of the bivariate analysis showed that there was a relationship between knowledge and practice of respondents regarding household disposable waste management (p-value = 0.002) and there was no relationship between information accessibility and respondents practices regarding household mask waste management (p-value = 0.352). The conclusion of this study is the public of Semarang city already having knowledge, accessibility of information and good practices regarding how to manage single-use mask waste in households. The ease of accessing information that is already owned by the community does not affect the practice of managing waste masks which has been done.
Sifat Kimia, Organoleptik, dan Mikroorganisme Dodol Susu dengan Penambahan Ekstrak Gotu Kola yang Bervariasi
Authors: Krisetyadi Brilly Cahyo , Pramono Yoyok Budi , Bintoro Valentinus Priyo
Published: May 2023

Penelitian ini bertujuan untuk mengetahui sifat kimia, organoleptik, dan mikroorganisme dari dodol susu dengan penambahan ekstrak gotu kola (Centella asiatica) dalam variasi yang berbeda serta mengetahui pengaruh penambahan ekstrak gotu kola terhadap sifat kimia, organoleptik, dan mikroorganisme terhadap dodol susu. Materi yang digunakan adalah ekstrak daun gotu kola dengan pelarut etanol 70% serta bahan untuk membuat dodol susu dengan larutan susu segar pasteurisasi dengan formulasi bahan baku yang berbeda tiap perlakuan.  Rancangan percobaan yang digunakan adalah Rancangan Acak Lengkap (RAL) dengan 5 perlakuan dan 4 kali replikasi. Penelitian ini terdiri dari formulasi yang dibagi menjadi dibagi atas 5 perlakuan berupa pemberian gotu kola dengan konsentrasi 0%, 2%,4%, 6%, 8%. Analisis data yang digunakan yaitu Analisis of Varian (ANOVA) pada taraf signifikansi 5%. Hasil menunjukkan bahwa dodol susu dengan pemberian ekstrak gotu kola memberi pengaruh nyata (p<0,05) terhadap sifat kimia dan organoleptik dodol susu. Ekstrak gotu kola juga mampu menghambat pertumbuhan kapang dalam dodol susu yang disimpan dalam 20 hari. Perlakuan dengan penambahan ekstrak gotu kola sebesar 2% merupakan perlakuan terbaik untuk parameter organoleptik secara menyeluruh. Chemical, Organoleptic, and Microorganism Characteristics of Dodol Made from Milk with Varied Gotu Kola AdditionThis Research was to determine the chemical, organoleptic, and microorganism characteristics of dodol made from milk with varied gotu kola extract (Centella asiatica) addition. The material used is gotu kola leaf extract with 70% ethanol, as well as materials for making dodol milk with pasteurized fresh milk solution with different raw material formulations for each treatment. The experimental design used was Completely Randomized Design (CRD) with 5 treatments with 4 replication. The study consists of a formulation which was divided into 5 treatments for the provision of gotu kola with a concentration of 0%, 2%, 4%, 6% and 8%. Data analysis used was Analysis of Variant (ANOVA) at 5% significance level. The result showed that dodol milk with giving of gotu kola extract gave real effect (p <0,05) to chemical and organoleptic properties of milk dodol. The results showed that milk dodol with gotu kola extract had a significant effect on the chemical and organoleptic properties of milk dodol. Gotu kola extract also could inhibit the growth of mold in milk dodol stored in 20 days. The addition of 2% of gotu kola extract is the best treatment for organoleptic parameters thoroughly.
Kualitas Selai Alpukat (Persea americana Mill) dengan Perisa Berbagai Pemanis Alami
Authors: Ramadhani Prima Dewi , Setiani Bhakti Etza , Rizqiati Heni
Published: May 2023

Penelitian ini bertujuan menguji kualitas selai alpukat yang dibuat dengan perlakuan 3 jenis pemanis alami berbeda ditinjau dari aspek kadar air, nilai aw, total sugar, total mikroba, total padatan terlarut, dan uji hedonik. Parameter penelitian meliputi kadar air, nilai aw, total sugar, total mikroba, total padatan terlarut dan kesukaan selai alpukat dengan perlakuan pemberian jenis pemanis T1=gula aren, T2=gula pasir, T3=madu. Penelitian ini menggunakan desain rancangan acak lengkap (RAL) dengan tiga perlakuan dan tujuh kali pengulangan. Data yang diperoleh dianalisis dengan menggunakan ANOVA untuk parameter kadar air, nilai aw, total sugar, total mikroba, total padatan terlarut. Sedangkan untuk parameter kesukaan menggunakan uji Kruskal Wallis. Hasil penelitian menunjukkan bahwa terdapat pengaruh pemberian jenis pemanis alami berbeda terhadap kualitas kadar air, nilai aw, total sugar, dan total padatan terlarut selai alpukat. Selai dengan pemberian pemanis gula aren merupakan perlakuan pemberian pemanis dengan kualitas terbaik yang menghasilkan selai alpukat dengan kadar air = 14,73%, nilai aw 0,832, total sugar 39,509%, total mikroba 5,3.103 CFU/g dan total padatan terlarut 81,9%. Dari segi kesukaan, selai dengan pemberian pemanis gula pasir paling disukai baik secara warna, rasa, aroma, tekstur, dan overall.
Kualitas Minuman Sinbiotik Bengkuang (Pachyrhizus erosus) Menggunakan Inokulum Lactobacillus fermentum dengan Waktu Inkubasi yang Berbeda
Authors: Zakiy Jundina Muthia , Dwiloka Bambang , Rizqiati Heni
Published: May 2023

Penelitian ini bertujuan untuk mengkaji pengaruh bakteri Lactobacillus fermentum dengan lama fermentasi yang berbeda dalam pembuatan minuman sinbiotik bengkuang, meliputi kadar serat pangan, total bakteri, pH, dan uji organoleptik. Kadar serat pangan sari bengkuang adalah 31%, setelah dilakukan penambahan inokulum kadar serat pangan mengalami penurunan hingga menjadi 22% yang disebabkan oleh degradasi pati oleh bakteri asam laktat. Total bakteri asam laktat minuman sinbiotik bengkuang tertinggi adalah 1,6x108 dan terendah adalah 4,5x107. Nilai pH minuman sinbiotik bengkuang semakin menurun dalam tiap perlakuan, pH tertinggi adalah 4,92 dan terendah adalah 3,44. Cita rasa sangat asam minuman sinbiotik bengkuang menurut panelis terdapat pada perlakuan inkubasi 48 jam sedangkan cita rasa tidak asam terdapat pada perlakuan inkubasi 12 jam. Minuman sinbiotik bengkuang yang paling disukai oleh panelis adalah pada perlakuan inkubasi 36 jam. Minuman sinbioitk bengkuang telah memenuhi standar minuman probiotik yang telah ditetapkan.
Aktivitas Antioksidan, Nilai pH, Kemuluran dan Uji Hedonik Keju Mozzarella dengan Penambahan Jus Umbi Bit (Beta vulgaris L)
Authors: Setiaji Wisnu Pangestu , Rizqiati Heni , Nurwantoro Nurwantoro
Published: May 2023

Penelitian ini bertujuan untuk mengetahui pengaruh penambahan jus umbi bit dalam pembuatan keju mozzarella terhadap aktivitas antioksidan, nilai pH, kemuluran serta uji hedonik atau kesukaan. Penelitian ini menggunakan rancangan acak lengkap dengan variasi perlakuan penambahan jus umbi bit berturut turut yaitu 0%, 2%, 4%, dan 6% (T0, T1, T2 dan T3). Parameter yang diamati meliputi aktivitas antioksidan, nilai pH, kemuluran dan uji hedonik atau kesukaan. Hasil penelitian yang dilakukan menunjukan bahwa pemberian jus umbi bit dalam pembuatan keju mozzarella keju mozzarella menunjukan adanya kenaikan aktivitas antioksidan. Pada parameter nilai pH dan kemuluran keju mozzarella menunjukan bahwa penambahan umbi bit tidak berpengaruh pada keduanya. Penambahan jus umbi bit pada keju mozzarella secara keseluruhan menurunkan tingkat kesukaan panelis pada parameter warna, rasa, tekstur dan overall.
Pengaruh Jenis Pemanis Yang Berbeda Terhadap Viskositas dan Nilai pH Sirup Ekstrak Daun Jahe (Zingiber Officinale)
Authors: Rizka Shindy Raviola , Susanti Siti , Nurwantoro Nurwantoro
Published: May 2023

Penelitian ini membahas tentang penggunaan jenis pemanis yang berbeda terhadap viskositas dan nilai pH sirup ekstrak daun jahe. Bahan yang digunakan adalah ekstrak daun jahe, propilen glikol, CMC, asam sitrat, aquades dan pemanis yang berbeda setiap perawatan. Penelitian disusun dengan Rancangan Acak Lengkap menggunakan 4 rancangan dan 5 kali ulangan dengan variasi jenis pemanis yang berbeda yaitu T 1 (sorbitol), T 2 (sukrosa), T 3 (HFS), dan T 4 (madu). Viskositas diterima dengan metode Ostwald dan nilai pH diperoleh dengan pH meter. Analisis data yang digunakan yaitu Analisis Varian (ANOVA) pada taraf signifikansi 5%.Hasil analisis menunjukkan bagaimana penggunaan jenis pemanis yang berbeda pada sirup ekstrak daun jahe memberikan nyata (P <0,05) terhadap nilai pH dan viskositas sirup ekstrak daun jahe. Viskositas sirup dan nilai pH sesuai dengan standar.
Pengaruh Rasio Pasta Kacang Hijau-Beras Hitam terhadap Karakteristik Sensoris Flakes Sereal
Authors: Apriliana Nur Wahyuningsih , Susanti Siti , Pratama Yoga
Published: May 2023

AbstrakPenelitian ini bertujuan untuk mengetahui pengaruh rasio pasta kacang hijau-beras hitam dalam formula flakes sereal terhadap karakteristik sensori yang dihasilkan. Pasta kacang hijau dan beras hitam sesuai perlakuan dicampurkan dengan tepung maizena, baking powder, baking soda, garam, madu, minyak dan susu, kemudian di cetak dengan dimensi 1,5x1,5x0,2 cm dan dipanggang pada suhu 120ºC selama 25 menit. Rancangan Acak Lengkap (RAL) digunakan dalam penelitian dengan 3 perlakuan berupa rasio pasta kacang hijau:beras hitam yaitu T0 (0%:100%), T1 (50%:50%), T2 (75%:25%) dan 7 pengulangan. Analisis data karakteristik sensori yang mencakup warna, aroma, tekstur, rasa dan overall dengan uji Kruskal-Wallis yang dilanjutkan dengan uji Mann Whitney U Test apabila terdapat pengaruh. Peningkatan rasio pasta kacang hijau terhadap beras hitam akan menyebabkan warna flakes sereal menjadi keabuan, tekstur tidak renyah, rasa semakin manis dan cukup disukai.
Neonatal stridor presents at home – vocal fold paralysis as rare presenting feature of CHARGE syndrome
Authors: Donnell Sierra S. , Kraemer Megan K. , Kadakia Suhagi M.
Published: May 2023

Objectives

To present an unusual presentation and diagnosis of CHARGE syndrome with vocal fold paralysis, a rarely associated congenital laryngeal anomaly, as the presenting feature.

Case presentation

A four-day old, full-term, male infant born via uncomplicated vaginal delivery with a nursery course significant for failed hearing screen presented to an emergency department (ED) with respiratory distress and worsening stridor. He was transferred to a level III neonatal intensive care unit (NICU) for further evaluation and required intubation due to progressive hypercarbia. Laryngoscopy revealed left-sided unilateral vocal fold paralysis (VFP). He underwent further evaluation that included a normal MRI brain, neck and chest. Genetics was consulted with concern for dysmorphic features on physical exam. Following gene panel testing, VFP was attributed to known association with CHARGE syndrome. Airway edema was noted on laryngoscopy that prevented extubation until two months of age. Further features of CHARGE syndrome identified included colobomas, glaucoma, sensorineural hearing loss, and genital abnormalities. He was discharged in room air and following gastrostomy tube placement with otolaryngology follow up.

Conclusions

Although choanal abnormalities are classically associated with CHARGE syndrome, other upper airway anomalies such as VFP may be present. VFP is a rarely reported anomaly in association with CHARGE syndrome (Naito Y, Higuchi M, Koinuma G, Aramaki M, Takahashi T, Kosaki K. Upper airway obstruction in neonates and infants with CHARGE syndrome. Am J Med Genet 2007;143A:1815–20; Morgan D, Bailey M, Phelps P, Bellman S, Grace A, Wyse R. Ear-nose-throat abnormalities in the CHARGE association. Arch Otolaryngol Head Neck Surg 1993;119:49–54).
The Artistic Character of the Spirit in the Beatus Tradition
Authors: Johnson David Ray
Published: May 2023

This article examines the visual interpretations of the Spirit in the Beatus illuminated manuscripts. This study will follow methods emerging in the discipline of visual criticism where visual art of biblical texts function like commentaries by offering visual interpretations. This study will investigate the visual interpretations of “John being in the Spirit” (Rev 1:10; 4:2; 17:3; 21:10) and the seven Spirits who are identified as the seven torches, the seven eyes, and the seven horns of the Lamb (Rev 1:4; 3:1; 4:5; 5:6) in the Beatus illuminated manuscripts.
Effect of metabolic control on cognitive functions in children and adolescents with type 1 diabetes mellitus
Authors: Kar Şeyma , Er Eren , Ata Aysun , İnal-Kaleli İpek , Özcan Tuğçe , Köse Sezen , Özbaran Burcu , Demir Günay , Özen Samim , Darcan Şükran , Gökşen Damla
Published: May 2023

Objectives

Neurocognitive functions of children with type 1 diabetes mellitus (T1D) are reported to be poorer than those of healthy peers. The aim was to investigate the effects of age of onset of diabetes, metabolic control, and type of insulin regimen on neurocognitive functions in children and adolescents with T1D.

Methods

Forty-seven children aged 6–18 years, with T1D for at least five years, were included. Children with a known psychiatric disorder or chronic diseases other than T1D were excluded. Intelligence via the Wechsler children’s intelligence scale (WISC-R), short-term memory via the audio-auditory digits form B (GISD-B) test, visual motor perception via the Bender Gestalt test, and attention via the Moxo continuous attention and performance test, timing, hyperactivity, and impulsivity (Moxo-dCPT) were assessed.

Results

Compared with the T1D group, healthy controls had higher scores in terms of verbal intelligence quotient (IQ), performance IQ, and total IQ mean scores on WISC-R (p=0.01, p=0.05 and p=0.01, respectively). On the MOXO-dCPT test, the T1D group had higher impulsivity compared to the control group (p=0.04). Verbal IQ was better in the moderate control group than in the poorer metabolic control (p=0.01). Patients with no history of diabetic ketoacidosis (DKA) had higher performance, verbal and total intelligence scores than the group with history of DKA.

Conclusions

Poor metabolic control and a history of DKA in children with T1D adversely affected neurocognitive functions. It would be beneficial to consider the assessment of neurocognitive functions in T1D and to take the necessary precautions in follow-up.
On H
2-solutions for a Camassa-Holm type equation
Authors: Coclite Giuseppe Maria , di Ruvo Lorenzo
Published: May 2023

Camassa-Holm type equations arise as models for the unidirectional propagation of shallow water waves over a flat bottom. They also describe finite length, small amplitude radial deformation waves in cylindrical compressible hyperelastic rods. Under appropriate assumption on the initial data, on the time

T

T

, and on the coefficients of such equation, we prove the well-posedness of the classical solutions for the Cauchy problem.
Effect of micro particle addition to the resin on the mechanical behavior of fiber reinforced composite plates
Authors: Ozcan Mehmet Erbil
Published: May 2023

In this study, laminated composite plate was produced from fiber reinforced fabric by vacuum infusion method. Composite plate was produced using glass fiber and epoxy resin. During production, B4C, TiC, TiO2, Al, Fe, and Ti powders were added to the resin in micro size and at 3 to 5 wt%. Test samples were obtained from the produced plate and subjected to wear test on pin-on disc type bench. For samples with 3 wt% additives, the wear rate increased significantly as the wear distance increased for each sample. In the case where the wear distance is maximum, the wear rate decreased the most in the TiC added sample. At the same time, TiC additive gave the lowest wear rate at 900–1800 m wear distance. For each sample with non-additive and 5 wt% additive, the wear rate increased linearly as the wear distance increased. When the wear distance is maximum, the wear rate decreased the most in the TiO2 added sample. The highest tensile strength reduction was obtained in B4C added sample as 50 wt% for 3 wt% additive and 61 wt% for 5 wt% additive.
The role of cytology in patients undergoing pressurized intraperitoneal aerosol chemotherapy (PIPAC) treatment for peritoneal carcinomatosis
Authors: Deban Mélina , Châtelain Julien , Fasquelle François , Clerc Daniel , Toussaint Laura , Hübner Martin , Teixeira Farinha Hugo
Published: May 2023

Objectives

Cytology of ascites or peritoneal washing is a routine part of staging of peritoneal metastases (PM). We aim to determine value of cytology in patients undergoing pressurized intraperitoneal aerosol chemotherapy (PIPAC).

Methods

Single-center retrospective cohort study included consecutive patients having PIPAC for PM of different primary between January 2015 and January 2020.

Results

A total of 75 patients (median 63 years (IQR 51–70), 67 % female) underwent a total of 144 PIPAC. At PIPAC 1 59 % patients had positive and 41 % patients had negative cytology. Patients with negative and positive cytology only differed in terms of symptoms of ascites (16% vs. 39 % respectively, p=0.04), median ascites volume (100 vs. 0 mL, p=0.01) and median PCI (9 vs. 19, p<0.01). Among 20 patients who completed 3 PIPACs (per protocol), cytology changed in one from positive to negative, and in two from negative to positive. Median overall survival was 30.9 months in the per protocol group and 12.9 months in patients having <3 PIPACs (=0.519).

Conclusions

Positive cytology under PIPAC treatment is more frequently encountered in patients with higher PCI and symptomatic ascites. Cytoversion was rarely observed and cytology status had no impact on treatment decisions in this cohort.
Emerging role of HJURP as a therapeutic target in cancers
Authors: Tan Jiaqi , Peeraphong Lertnimitphun , Ruchawapol Chattarin , Zhang Juan , Zhao Juan , Fu Wenwei , Zhang Li , Xu Hongxi
Published: May 2023

Holliday junction recognition protein (HJURP) is a key molecular chaperone for centromere protein A (CENP-A), which is essential for chromosome separation during mitosis and cell cycle regulation. Recent studies have identified the essential role of HJURP in carcinogenesis. Abnormal upregulation of HJURP expression has been observed in various human cancers, such as non-small cell lung cancer (NSCLC), hepatocellular carcinoma (HCC), bladder cancer, and breast cancer, and is associated with poor pathologic development and prognosis. In vitro and in vivo studies have shown that HJURP mainly exerts oncogenic functions by regulating the cell cycle, cellular senescence, and epithelial-mesenchymal transition (EMT). The purpose of this review was to evaluate the prognostic significance of HJURP in human cancers and summarize anti-tumor studies targeting HJURP. The factors regulating HJURP in carcinogenesis and the corresponding effects are also discussed to provide new insight into targeting HJURP as a promising strategy for cancer treatment.