bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Dl-3-n-Butylphthalide on Mitochondrial Cox7c in Models of Cerebral Ischemia/Reperfusion Injury
Authors: Jia Jingjing , Deng Jianwen , Jin Haiqiang , Yang Jie , Nan Ding , Yu Zemou , Yu Weiwei , Shen Zhiyuan , Lu Yuxuan , Liu Ran , Wang Zhaoxia , Qu Xiaozhong , Qiu Dong , Yang Zhenzhong , Huang Yining
Published: July 2022

Several studies have demonstrated the protective effect of dl-3-n-Butylphthalide (NBP) against cerebral ischemia, which may be related to the attenuation of mitochondrial dysfunction. However, the specific mechanism and targets of NBP in cerebral ischemia/reperfusion remains unclear. In this study, we used a chemical proteomics approach to search for targets of NBP and identified cytochrome C oxidase 7c (Cox7c) as a key interacting target of NBP. Our findings indicated that NBP upregulated Cox7c, subsequently, inhibited mitochondrial apoptosis, and the release of reactive oxygen species (ROS), increased the production of ATP, improved mitochondrial respiratory capacity, and upregulated the HIF-1α/VEGF pathway, helped to maintain the mitochondrial membrane potential and the integrity of the blood-brain barrier and to promote angiogenesis. Therefore, our findings provided a novel insight into the mechanisms underlying the neuroprotective effects of NBP, and also proposed for the first time that Cox7c exerts a critical role by protecting mitochondrial function.
Exercise serum regulate uric acid transporters in normal rat kidney cells
Authors: Jiang Zhong-Ye , Cao Jian-Min , Su Hao , Cao Hui , Sun Ze-Yuan , Jiang Hao-Ze , Fan Yan-Jun
Published: July 2022

Objective: In this study, we tested the hypothesis that circulating factors produced during exercise regulate the expression of ABCC4, ABCG2, URAT1, and GLUT9 in normal rat kidney and NRK-52E cells and their relationship with NF-κB and NRF-2. Method: NRK-52E cells were separately cultured by serum from 10 healthy SD rats who did not exercise (CON) and 10 healthy SD rats who did aerobic treadmill exercise for 6 weeks, and cells cultured by serum from rats who did aerobic treadmill exercise for 6 weeks were separated by without NRF-2 inhibitor (EXE) and with NRF-2 inhibitor (EXE+ML). results: Aerobic exercise reduced serum uric acid level in rats, but had no significant effect on liver xanthine oxidase. It also increased the expression of some uric acid transporters in kidney and NRK-52E cells and increased the ability of cells in uric acid excretion. When the NRF-2 were inhibited, the expression of NF-κB and ABCG2 increased, and the expression of ABCC4, URAT1 and GLUT9 decreased. Conclusion: this study suggested that 6 weeks of aerobic treadmill exercise intervention may help to improve the excretion of uric acid in renal cells, suggesting that long-term aerobic exercise may be a means to prevent or treat hyperuricemia.
DVSP: An integrated database of virus spike proteins
Authors: Ye Yuan-Nong , Zheng Liu-Feng , Zhang Xiao-Ya , Liang Ding-Fa , Zeng Zhu
Published: July 2022

Spike protein is a class I virus fusion glycoprotein that plays an important role in cell infection by mediating receptor binding and membrane fusion during virus invasion. The fusion mechanism between virus and host cell mediated by spike protein is complex, and alterations via mutation can affect viral pathogenicity and have been linked with virus pandemics. In-depth studies of the biology and toxicology of viruses that pose a potential public health threat have promoted the use of bioinformatic approaches to explore the structure, function, and evolution of spike proteins. Therefore, data related to spike proteins have increased exponentially. To facilitate further biomedical research, these data require integration. Here, we developed a database of virus spike proteins (DVSP), which provides a free data and bioinformatics service for the scientific community. The DVSP contains 35,579 spike protein and 35,175 nucleotide sequences collected from viruses. Among these, 16,027 spike proteins and 15,623 pre-translational nucleotide sequences are derived from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the ongoing corona virus disease 2019 (COVID-19) pandemic. Overall, the DVSP provides 19,552 virus classifications based on integration and virus taxonomy, annotation information from the GenBank database, and sequence information. The sequences, virus taxonomy, and host information contained in the DVSP provide an important resource for future pathogenicity, evolutionary, and drug development studies. It serves as a valuable and comprehensive knowledge source for exploring the distribution, structure, and phylogeny of spike proteins in viruses, thereby promoting the formulation of new hypotheses and experimental designs for spike protein studies. The DVSP is a centralized reference and resource for biological information about the spike proteins of viruses (including coronavirus), which is available at http://yeyn.group:90/.
Household Wealth Differential and Under-five Child Deaths in Ghana: Implications for Child Health Policy
Authors: Osei Christian Kwaku , Nketiah-Amponsah Edward
Published: July 2022

Background
At the end of the MDG era, although Ghana was one of the few countries commended to have halved extreme poverty, the under-five mortality rate (U5MR) was dire. Currently, U5MR is still below the national and global SDG target. Government has over the years introduced various social and policy interventions to improve on the socioeconomic status of households to aid in better health outcomes. In this regard, we hypothesize that household wealth should therefore not influence under-five child deaths significantly.
Methods
The paper first reports under-five mortality trend over the past 30 years in Ghana. It uniquely analyses the levels and trends in wealth as measured by the Gross National Income per capita at purchasing power parity (ln GNI/p, ppp) as a proxy of the mean Comparative Wealth Index (CWI) against under-five child deaths in Ghana. Using data from the 2014 Ghana Demographic and Health Survey and employing the logistic regression estimation technique, the paper further estimates the effect of household wealth and other control variables on under-five child deaths.
Results
The trend analysis reveal that if the current rate of reduction of U5MR persists, Ghana may not achieve the SDG target. Our empirical estimations also show that household wealth still has a negative and significant relationship with under-five child deaths despite existing poverty alleviating policies. In addition, the results show that regional differences, maternal age, the number of children alive and maternal attendance to postnatal healthcare services are crucial for child survival.
Conclusion
The results imply that targeted government interventions towards improving household wealth should be intensified especially at the Northern Savannah regions. A new child health policy is imminent to reflect strategies towards achieving the SDG target on U5MR. Additionally, intensive education on active maternal participation in postnatal care should be given critical consideration to improve child survival.
Coding-Elite Particle Swarm Optimization Searching of Moving Targets by UAVs
Authors: Xie Zixuan , Huang Xueyu , Liu Wenwen , Zhu Donglin
Published: July 2022

This paper proposes an elite coded particle swarm optimization (CEPSO) unmanned aerial vehicles (UAVs) search target motion for target detection in the shortest time. According to Bayesian theory, the problem of moving object searched is transformed into the optimization of cost function, which is used to describe the probability of moving objects being found. In order to better fit the problem, a coded elite particle swarm optimization algorithm is used to encode the search trajectory of the UAV as the movement path of the particle in the process of generation and evolution. This coding method uses the cognitive properties and social learning properties of particle swarms to generate better solutions. At the same time, in order to increase the diversity of particle swarms, a method of elite particle perturbation is used, which greatly improves the detection probability. In order to verify the superiority of the algorithm in this paper, a large number of simulation experiments are carried out on the existing methods. The experimental results show that compared with PSO, the detection probability of the proposed CEPSO is improved by 6.9%, and the time performance is improved by 8.5%. It also compares with other meta-heuristic algorithms, including differential evolution (DE), artificial bee colony (ABC), harmony search (HS), biogeographic-based optimization (BBO), invasive weed optimization (IWO), teaching-learning-based Optimization (TLBO). The experimental results show that the algorithm proposed in this paper has better detection accuracy and less detection time.
Risk factors of primary postpartum hemorrhage among postnatal mothers in the public hospital of southern Tigray, Ethiopia, 2019: a case-control study
Authors: Muluye Getachew , Woretaw Lebasie , Girma Biniam , Tumebo Tarekegn
Published: July 2022

Background: Postpartum hemorrhage is the most common direct cause of maternal mortality and morbidity among them, primary postpartum hemorrhages are an enormous element. Although it has an incredible impact on maternal lifestyle, this is the most neglected area in Ethiopia and there aren’t studies achieved within the study area. The purpose of this study is to identify the risk factors of primary postpartum hemorrhage among postnatal mothers in public hospitals in southern Tigray, Ethiopia, 2019 Methods: Hospital-based unmatched case-control study design was conducted on 318 (106 case & 212 controls) postnatal mothers in public hospitals of Southern Tigray from January to October 2019. The data had been collected by using an interviewer-administered structured questionnaire and chart review. Bivariate and multivariable logistic regression models were used to identify the risk factors. P-value < 0.05 was considered for statically significance for both steps and an odds ratio with a 95% confidence level was used to see the strength of association. Results: Abnormal third stage of labor [AOR = 5.86, 95%; CI:(2.55-13.43); P-value=000], Cesarean section [AOR= 5.61, 95%; CI: (2.79-11.30); p-value=0.000], lack of AMTOL [AOR=3.88; 95%; CI: (1.29 - 11.60); P= 0.015], absence of labor monitoring [AOR=3.82; 95%; CI: (1.31-11.09); P=0.014], Lack of antenatal care [AOR=2.76, 95%, CI: (1.13–6.75); P-value=0.026] and complications during pregnancy [AOR=2.79, 95%, CI; (1.34-5.83), P-value=0.006] were found to be risk factors of primary postpartum hemorrhage. Conclusions: in this study complications and lack of maternal health interventions in the course of the antepartum and in the intrapartum period were found to be risk factors for primary postpartum hemorrhage. A strategy toward improving essential maternal health services and detecting and handling complications in a timely and proper manner will help to prevent primary postpartum hemorrhage.
Molecular hydrogen promotes wound healing by inducing early extracellular matrix deposition and epidermal stem cell proliferation
Authors: Zhao Pengxiang , Dang Zheng , Liu Mengyu , Guo Dazhi , Luo Ruiliu , Adzavon Yao Mawulikplimi , Zhang Mingzi , Xie Fei , Zhang Xujuan , Wang Youbin , Pan Shuyi , Ma Xuemei
Published: July 2022

Background
Despite progress in developing wound care strategies, there is currently no treatment that promotes the self-tissue repair capabilities. H2 has been shown to effectively protect cells and tissues from oxidative and inflammatory damage. While comprehensive effects and how H2 functions in wound healing are still obscure.
Methods
Here, we established a cutaneous aseptic wound model and applied a high concentration of H2 (66% H2) in a treatment chamber. Molecular mechanisms and the effects of healing were evaluated by gene functional enrichment analysis, blood perfusion/oxygen detection assay, in vitro tube formation assay, enzyme-linked immunosorbent assay, immunofluorescent staining, non-targeted metabonomic analysis, flow cytometry, transmission electron microscope, and live-cell imaging.
Results
We revealed that a high concentration of H2 (66% H2) greatly increased the healing rate (3 times higher than the control group) on day 11 post wounding. The effect was not dependent on O2 or anti-reactive oxygen species functions. Histological and cellular experiments proved the fast re-epithelialization in the H2 group. Extracellular matrix components early (3 days post wounding) deposition were found in the H2 group of the proximal wound, especially for the dermal col-I, epidermal col-III, and dermis-epidermis-junction col-XVII. H2 accelerated early autologous epidermal stem cell proliferation (1–2 days in advance) and then differentiation into myoepithelial cells. Other beneficial outcomes include sustained moist healing, greater vascularization, less T-helper-1 and T-helper-17 cell-related systemic inflammation, and better tissue remodelling.
Conclusion
We have discovered a novel pattern of wound healing induced by molecular hydrogen treatment. These H2-induced multiple advantages in healing may be related to the enhancement of cell viability in various cells and the maintenance of mitochondrial functions at a basic level in the biological processes of life.
How does the quantum structure of electromagnetic waves describe quantum redshift?
Authors: Kalhor Bahram
Published: July 2022

The redshift of the electromagnetic waves is a powerful tool for calculating the distance of the objects in space and studying their behavior. However, physicists' misinterpretation of why Redshift occurs has led us to a misunderstanding of the most cosmological phenomena. The paper introduces Quantum Redshift (QR) by using the quantum structure of the electromagnetic waves (QSEW) In the Quantum Redshift, although the Planck constant is the smallest unit of three-dimensional energy, it is consisting of smaller units of one-dimensional energy. The maximum energy of each period of the electromagnetic waves is equal to the Planck constant hence, the capacity of each period is carrying one-dimensional quanta energy. However, in the QR, at the emitting time of the electromagnetic waves, their periods are not fully filled. On the other hand, they are interested in sharing quanta energies with each other to have full filled periods. Sharing the quanta energies ofا some periods between other periods is the reason for destroying some periods and decreasing the frequency of the electromagnetic waves. Our other studies show Quantum Redshift can well explain the whole phenomenon of the universe, and real data support our theory. The quantum redshift rejects the big bang theory, expansion of space and dark energy. It predicts dark matters and describes CMB. The paper obtains the basic equation of the QR for use in future papers.
Polymer composites and their properties
Authors: Lebedeva O. V. , Sipkina E. I.
Published: July 2022

The review article summarizes the results of studies conducted in the field of polymer composites obtained by various methods. An important industrial activity is structured around the development of polymeric materials and composites based on them. Composite materials having a matrix comprised of a polymeric material (polymers, oligomers, copolymers) are highly numerous and diverse. They are widely used in the industry for the manufacture of vitreous, ceramic, electrically insulating coatings, as adsorbents in the treatment of wastewater from heavy metal ions, and in the production of ion-exchange membranes. Composite materials have unique properties such as a large surface area, thermal and mechanical stability, good selectivity against various contaminants, and cost-effectiveness. The review presents the physicochemical and structural characteristics of composite materials based on synthetic polymers (polymer-carbon, polymerclay composites), polymeric heterocyclic and organosilicon compounds. Used across a variety of applications, polymer-carbon and polymer-clay composites are effective in removing organic and inorganic contaminants. However, when used as adsorbents for large-scale production, they have yet to achieve optimum performance. Hybrid materials obtained by the sol-gel method deserve special attention. This method can be conveniently used to influence the composition and structure of the surface layer of such materials as adsorbents of heavy and noble metals, catalysts, membranes and sensors for applications in biological antibiosis, ion exchange catalysis, etc. Such composites are characterized by their increased mechanical strength and thermal stability, as well as offering improved thermochemical, rheological, electrical and optical properties.
PERCEPCIÓN DE LOS ESTUDIANTES DE LA FACULTAD DE ORGANIZACIÓN DEPORTIVA SOBRE LA EDUCACIÓN EN LÍNEA, EN TIEMPOS DE PANDEMIA COVID 19
Authors: Corrales Félix Gloria Leticia , González Castro Juan Carlos Arturo , Tostado Assid Juana María
Published: July 2022

Las actividades del mundo cambiaron con el surgimiento de la pandemia COVID 19. El cierre de escuela y universidades afectó el desarrollo de la educación de millones de estudiantes, originando que la educación se trasladara a la modalidad en línea para continuar con la formación educativa. Este trabajo de investigación tiene como objetivo identificar el modelo de enseñanza aplicado en línea, y conocer la percepción y valoración de los estudiantes frente a la modalidad en línea. La investigación corresponde al tipo descriptivo y se aplicó una encuesta de 25 ítems a estudiantes de la Facultad de Organización Deportiva (FOD), de la Universidad Autónoma de Nuevo León (n = 321). Los resultados muestran que los estudiantes utilizan smartphones para conectarse a las clases, desde sus casas. Las clases en línea recibidas han sido principalmente a través de presentaciones con interacción sincrónica y comunicación por medio de foros. La valoración de los estudiantes sobre la educación en línea es que invierten mayor dedicación a sus estudios, pero esto no se refleja en su rendimiento académico, a pesar de que han desarrollo el autoaprendizaje y los docentes se adaptan a sus necesidades personales. En conclusión, se considera que la Facultad y los docentes deben implementar estrategias centradas en el estudiante, contextualizadas a la modalidad en línea, creativas e innovadoras, para lograr aprendizajes y que el alumno desarrolle el pensamiento crítico.
Utilization of Expired Platelet Concentrate for Production of Human Platelet Lysate as a Medium for T47D Cell Propagation
Authors: Mentari Diani , Pebrina Relita , Nurpratami Diah
Published: July 2022

Background: Platelet concentrate (PC) has a short shelf life (5 days). Expired PC cannot be used for clinical purposes. PC is used for human platelet lysate (HPL) production, which was found to be more effective than FBS at increasing T47D cell proliferation. HPL production using expired PC has not been reported. This study aimed to investigate whether the use of HPL produced from expired PC (storage duration >5 days) can increase the proliferation of T47D cells in vitro.Materials and methods: Expired PC samples with a shelf life of 7 and 11 days were used to produce HPL via freeze/thaw method. pH, total protein content, glucose and albumin levels were measured. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to measure proliferation rate and doubling time of HPL-treated T47D cells.Results: After HPL production, the glucose level was influenced by the pH (p=0.003), and albumin level was influenced by total protein content (p=0.030). HPL stored for 7 and 11 days increased cell proliferation rate by 1.41 and 1.80 times higher than 10% FBS, respectively. HPL produced from expired PC did not cause morphological abnormality of the cells. In this study, the glucose levels affected cell proliferation (p=0.030). High glucose levels inhibited T47D cell proliferation.Conclusion: Expired PC can be used as a potential material for HPL production, since HPL produced from expired PC increases cell proliferation rate and shortens cell doubling time.Keywords: cell proliferation, human platelet lysate, platelet concentrate, thrombocyte, T47D
Pregnant women's perceptions of anemia and iron supplement consumption
Authors: Muthoharoh Binti Lu’lu’ , Kartini Farida , Fitriahadi Enny
Published: July 2022

Anemia is a condition that is commonly indicated by low hemoglobin levels in the blood. This situation is proven by the lack of quality and quantity of red blood cells that consequently decrease the amount of oxygen transported into the tissue. The high incidence of anemia in pregnancy can cause high maternal mortality after childbirth resulting from pregnancy complications such as bleeding. A lot of research on the factors that influence anemia and the prevention of anemia during pregnancy has been conducted previously. However, there is still few of research exploring women's perception of anemia and the consumption of iron supplements. This Scoping Review aims to determine the extent of women's perception of anemia and iron supplement consumption. The method used is Scoping Review using Wiley Online Library, PubMed, and ScienceDirect databases. The research results that match the criteria are then analyzed with the aim of generating these articles. Appropriational study applied here uses Joana Briggs Institute (JBI), and the synthesis method uses PEOS modification. Six of the 141 articles relevant to titles and abstracts met the inclusion and exclusion criteria.
Apuestas a la igualdad, imperativos de la inclusión
Authors: Vassiliades Alejandro
Published: July 2022

Este artículo presenta resultados de una investigación acerca de los modos en que el trabajo docente ha venido procesando un conjunto de sentidos en torno de la inclusión puestos a circular por las políticas públicas en educación en Argentina implementadas entre 2003 y 2015. El trabajo de campo se desarrolló en tres escuelas primarias públicas de la provincia de Buenos Aires, a las que asistían poblaciones de estudiantes que vivían en condiciones de pobreza. Desde una perspectiva interpretativa, la investigación se orientó a describir, comprender y analizar los sentidos que los sujetos docentes otorgan a sus prácticas frente a situaciones de sobreedad, reconstruyendo una pluralidad de estrategias pedagógicas. El artículo da cuenta de diversas posiciones en cuanto al abordaje de la sobreedad que ponen en tensión la construcción de lo común y la atención diferenciada a las particularidades de los alumnos, identificando estrategias denominadas con las categorías “sobreedad temporaria”, “sobreedad disputada” y “gueto de sobreedad”.
Artes, oficios y saberes locales
Authors: Ibarra Vallejos Ivan Alexander , Alcântara Schlemer Liliane Christine , Henríquez Zúñiga Christian
Published: July 2022

El objetivo de esta investigación consiste en proponer un diseño de proyecto educativo, desde las artes y oficios locales, que pueda contener elementos del Desarrollo a Escala Humana y del Buen Vivir, considerando que estas perspectivas distinguen como eje principal el bienestar, la calidad de vida y la satisfacción de necesidades, respetando la identidad y las características específicas de las comunidades, poniendo énfasis en la escala local-regional. Para ello, se analiza la satisfacción de las Necesidades Humanas Fundamentales en la comunidad São Gonçalo Beira Rio, Cuiabá, capital del Estado de Mato Grosso, Brasil, en su vínculo con los diferentes procesos de transmisión de artes, oficios y saberes. Metodológicamente, se desarrolla una investigación descriptiva-cualitativa, con enfoque etnográfico y socio-crítico, que incluyó la aplicación de la Matriz de Necesidades Humanas Fundamentales, instrumento metodológico propuesto por el Desarrollo a Escala Humana. Con los datos analizados, se elabora el estudio de caso instrumental “Cerámica en arcilla: ascenso, riesgo y trascendencia”, que relata parte de la experiencia vivida por la Asociación de Artesanas de la comunidad en la lucha por la preservación, transmisión y difusión de su cultura. Finalmente, se proponen reflexiones y acciones que se traducen en el diseño de un microsistema educativo, materializado en una escuela de artes y oficios nutrida por los saberes y tradiciones que forman parte de la identidad local y elaborado de manera colaborativa y participativa. Hay mucho que avanzar en la actualidad, sin embargo, este trabajo es una contribución para el presente y el futuro.
The Tree Performance and Physical Attributes Determination for Outdoor Student Education Learning Centre Project Proposal
Authors: Amir Atikah Fukaihah , Borhan Ruwaidah , Hamzah Helmi , Ravari Fatemeh Khozaei
Published: July 2022

University students deserve proper outdoor learning centers to accelerate their academic development. However, dealing with dynamic physical outdoor elements, especially the existing tree species, is challenging in the design phase. Failing to understand their character and conditions will lead to design failures that involve losses of ecosystem benefits and ultimately have a negative impact on students' academic development. This research proposes composite maps by analyzing qualitative and quantitative data from physical attributes. The proposed overlayed composite maps present the association of comfort, movement, aesthetic, and social relation criteria for the outdoor student learning centres.
Keywords: Plant Community, Plant Identification, Tree Conditions, Map Overlay
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7i20.3422
Interrelation of Transit-Oriented Development with Land Use Planning
Authors: Abdullah Yusfida Ayu , Jamaluddin Nor Baizura , Yakob Hamizah , Wang Yu
Published: July 2022

The ineffectiveness of public transport discourages participation from the public. Thus, the transportation systems and land use planning need to be more practical. This study explores the land use criteria that need to be considered while planning rail-based transit-oriented development (TOD). The method systematically reviewed the land use characteristics for transit-oriented development. Thematic Analysis was employed by applying scoping techniques. The result showed a network mapping of the interrelation between land use planning and Transit-Oriented Development and various land use criteria used as indicators in gauging TOD regions.
Keywords: Transit-Oriented Development (TOD); land use integration; land use criteria
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7i20.3452
Additional eﬀects of diosmin in the treatment of arterial hypertension in patients with impaired renal venous blood ﬂow
Authors: Zhdamarova O. I. , Eliseeva L. N. , Urban P. I.
Published: July 2022

Objective: to estimate of the eﬀect of diosmin in complex antihypertensive therapy on renal function in patients with hypertension and impaired renal venous blood ﬂow.

Materials and methods: we observed 147 patients with hypertension aged 40.86±8.27 with signs of bilateral impairment of venous blood ﬂow in the kidneys, which, depending on the amount of therapy, were divided into 2 groups and 2 subgroups. The comparison group consisted of 57 AH patients with unchanged venous blood ﬂow in both kidneys.

Results: in the presence of impaired venous blood ﬂow in the renal veins, the use of additional administration of diosmin allows maintaining or improving the ﬁltration capacity of the kidneys. Additional monitoring of patients with impaired venous blood ﬂow in the kidneys is required to assess the eﬀectiveness of antihypertensive therapy with individual drugs with and without venoactive agents.

Conclusion: the additional inclusion of diosmin in the complex antihypertensive therapy of patients with arterial hypertension and impaired venous blood ﬂow to the kidneys can preserve and improve kidney function with normalization of GFR.
Inﬂuence of metabolic disorders on the development of renal pathology
Authors: Bashkinov R. A. , Batluk T. I. , Melnikov E. S. , Trubnikova M. A. , Arutyunov A. G.
Published: July 2022

A large contribution to the development of kidney pathology, including the progression of chronic kidney disease, is made by risk factors associated, among other things, with impaired metabolic processes. These include disorders of carbohydrate metabolism (prediabetes, diabetes mellitus), dyslipidemia, overweight, obesity, metabolic syndrome, hyperuricemia. Timely identiﬁcation of these factors and their correction can be crucial for the patient in the context of kidney damage. The review presents data on the impact of disorders of carbohydrate, lipid and purine metabolism, overweight and obesity on the formation of kidney pathology.
Stock Market Synchronization and Stock Volatility: The Case of an Emerging Market
Authors: Magner Pulgar Nicolás , Terán Sánchez Esteban José Antonio , Guzmán Muñoz Vicente Alfonso
Published: July 2022

The purpose of this paper is to study the effect of stock market synchronization on the volatility of its component assets. For this objective, we calculate the stock market's synchronization using the Minimum Spanning Tree Length (MSTL) network analysis method. Then, we implement forecasting tests in and out the sample to assess the forecasting power on the stock market's synchronization to predict the individual stock realized volatility. Additionally, we test a VAR and a forecast error variance decomposition analysis to study Granger causality's presence on volatility. Our results show that synchronization within a market exists and changes over time. Our main results show that an increase in synchronization causes an increase in financial assets' realized volatility in the following month. Our results made it possible to study financial markets' synchronization and take a systemic risk approach to improve investment management. Our main idea was that the stock markets' synchronization positively correlates with financial assets' volatility. The greater the synchronization, the greater the volatility in the following period. This study offers a new approach to study the stock market volatility.
Using Social Media to Predict Food Deserts in the United States: Infodemiology Study of Tweets
Authors: Sigalo Nekabari , St Jean Beth , Frias-Martinez Vanessa
Published: July 2022

Background

The issue of food insecurity is becoming increasingly important to public health practitioners because of the adverse health outcomes and underlying racial disparities associated with insufficient access to healthy foods. Prior research has used data sources such as surveys, geographic information systems, and food store assessments to identify regions classified as food deserts but perhaps the individuals in these regions unknowingly provide their own accounts of food consumption and food insecurity through social media. Social media data have proved useful in answering questions related to public health; therefore, these data are a rich source for identifying food deserts in the United States.

Objective

The aim of this study was to develop, from geotagged Twitter data, a predictive model for the identification of food deserts in the United States using the linguistic constructs found in food-related tweets.

Methods

Twitter’s streaming application programming interface was used to collect a random 1% sample of public geolocated tweets across 25 major cities from March 2020 to December 2020. A total of 60,174 geolocated food-related tweets were collected across the 25 cities. Each geolocated tweet was mapped to its respective census tract using point-to-polygon mapping, which allowed us to develop census tract–level features derived from the linguistic constructs found in food-related tweets, such as tweet sentiment and average nutritional value of foods mentioned in the tweets. These features were then used to examine the associations between food desert status and the food ingestion language and sentiment of tweets in a census tract and to determine whether food-related tweets can be used to infer census tract–level food desert status.

Results

We found associations between a census tract being classified as a food desert and an increase in the number of tweets in a census tract that mentioned unhealthy foods (P=.03), including foods high in cholesterol (P=.02) or low in key nutrients such as potassium (P=.01). We also found an association between a census tract being classified as a food desert and an increase in the proportion of tweets that mentioned healthy foods (P=.03) and fast-food restaurants (P=.01) with positive sentiment. In addition, we found that including food ingestion language derived from tweets in classification models that predict food desert status improves model performance compared with baseline models that only include socioeconomic characteristics.

Conclusions

Social media data have been increasingly used to answer questions related to health and well-being. Using Twitter data, we found that food-related tweets can be used to develop models for predicting census tract food desert status with high accuracy and improve over baseline models. Food ingestion language found in tweets, such as census tract–level measures of food sentiment and healthiness, are associated with census tract–level food desert status.
Nurses’ Work Concerns and Disenchantment during the COVID-19 Pandemic: Machine Learning Analysis of Online Discussions (Preprint)
Authors: Jiang Haoqiang , Castellanos Arturo , Castillo Alfredo , Gomes Paulo J , Li Juanjuan , VanderMeer Debra
Published: July 2022

BACKGROUND

Nurse stories about their experiences during the COVID-19 pandemic offer significant opportunities for healthcare organizations to understand how their primary caregivers are affected by external pressures and internal managerial decisions.

OBJECTIVE

The objective of this study is to examine the evolution of nurses’ work concerns during the COVID-19 pandemic using conversations posted by nursing professionals in social media.

METHODS

We analyzed 14,060 posts related to the COVID-19 pandemic from March 2020 to April 2021. The data analysis stage included unsupervised machine learning and thematic qualitative analysis. We used an unsupervised machine learning approach, Latent Dirichlet Allocation (LDA) to identify salient topics in the collected posts. A human-in-the-loop (HITL) analysis complemented the machine learning approach, categorizing topics into themes and sub-themes. We develop insights on nurses’ evolving perspective based on temporal changes.

RESULTS

We identified themes for bi-weekly periods and grouped them into 20 major themes based on the work concerns inventory framework. Dominant work concerns varied during the specific time period. A detailed analysis of patterns in how themes evolve over time enables us to create narratives of work concerns.

CONCLUSIONS

This study showed that online conversation data and machine learning approaches can enable research into work concerns and workplace stressors during the COVID-19 pandemic. The study shows that monitoring and assessment of online discussions could provide useful data for healthcare organizations responses and planning during crises.
Depressive Symptoms Predict Longitudinal Changes of Chronic Inflammation at the Transition to Adulthood: Based on Restricted Cubic Spline Model (Preprint)
Authors: Zhai Shuang , Li Tingting , Zhang Dan , Qu Yang , Xie Yang , Wu Xiaoyan , Zou Liwei , Yang Yajuan , Tao Fangbiao , Tao Shuman
Published: July 2022

BACKGROUND

Inflammation closely relate to poor mental and physical health, including depressive symptoms. However, few studies have explored the linear and nonlinear relationship between depressive symptoms and chronic inflammation levels among college students by using a prospective design.

OBJECTIVE

We aimed to reveal the relationships and the direction of the relationships between depressive symptom severity at baseline and inflammatory cytokine levels at baseline and after 2 years of follow-up among college students.

METHODS

In this longitudinal study, we examined 248 college students recruited from two universities in south-central China, who were examined at baseline and after 2 years of follow-up based on a questionnaire survey of online follow-up monitoring. Depressive symptoms were measured by applying the Patient Health Questionnaire 9 (PHQ-9) at baseline. Plasma levels of three inflammatory cytokines, including interleukin-6 (IL-6), interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) were assayed at baseline and 2-year follow-up. In addition to the conventional generalized linear models, as well as restricted cubic splines were innovatively used to analyze cross-sectional and longitudinal nonlinear relationship between depressive symptoms and inflammatory cytokines.

RESULTS

The 248 college students consisted of 42.3% males and had a mean (SD) age of 18.69 (0.97) years at baseline. Generalized linear model analysis revealed that there were no statistical associations between depressive symptoms at baseline and any inflammatory cytokine levels at baseline or at 2-year follow-up. The results of restricted cubic spline demonstrated an inverted U-shaped nonlinear cross-sectional statistical link between depressive symptoms and TNF-α at baseline. Furthermore, longitudinal analyses showed that U-shaped nonlinear association between depressive symptoms and ΔIL-1β or ΔTNF-α (changes in baseline and 2-year follow-up).

CONCLUSIONS

Our findings suggested that nonlinear dose-response relationship between depressive symptoms and TNF-α at baseline, changes in IL-1β and TNF-α levels during a 2-year follow-up among college students. Simultaneously, more research is warranted to seek the directionality of depressive symptoms and chronic inflammation.
KASYF PHENOMENON IN THE DEFOCALIZATION OF RATIONALITY: A MAGICAL REALIST PERSPECTIVE ON GUS MUS’S GUS JAKFAR
Authors: Al-Mubarok Muhammad Rizqy , Purwitasari Tya Asih Dayu , Pambudi Rekno Wulandari
Published: July 2022

Gus Jakfar won the best short story in Kompas daily in 2004. This short story by Gus Mus tells of the story of a character named Gus Jakfar who has the privilege of forseeing other people’s fate just by looking at ‘signs’ (kasyf). Later, Gus Jakfar stopped seeing signs after his trip to meet Kiai Tawakkal. The phenomenon of seeing precognitive signs cannot be rationally understood by modern knowledge. The study of Gus Jakfar in the present article adopts magical realism from Wendy B. Faris’ perspective as a theoretical framework to examine kasyf as a defocalization narrative in short stories. The method of this study is descriptive analysis. The evidence to support the analysis includes words, phrases and sentences in the short story that are relevant to magical realist perspective, particularly in relation to the five elements of magical realism and defocalization. The analysis and description are carried out after collecting pieces of evidence from the short story. The analysis in this study shows that Gus Jakfar has the five characteristics of magical realism in it. From the five characteristics reflected in the text, there is an element called kasyf that is found to be an attempt of defocalization which is presented by the author using a mirroring technique. Kasyf in this short story is depicted from three perspectives. Although modern rationality has influenced people's identities, the pesantren tradition has not been abandoned. In this context, the kasyf phenomenon is understood as an alternative source of magical knowledge beyond the modern rational knowledge.
“PLEASE DON’T TREAT ME LIKE A SERVANT. I DO HAVE MY RIGHTS”: INDONESIAN MIGRANT DOMESTIC WORKERS (IMDWS) WROTE BACK IN FAMILIAR STRANGERS (2018)
Authors: Trisnawati Ririn Kurnia
Published: July 2022

Facilitated by The Voice of Singapore’s Invisible Hands, a non-profit organization (NPO) that promotes the rights and welfare of migrant workers in Singapore through literary works on Facebook, some Indonesian Migrant Domestic Workers (IMDWs) in Singapore such as Seruni, Fadillah, et. al., to name a few, have been able to publish their poems and short stories in an anthology entitled “Familiar Strangers” (2018). To add to the current studies of literary works written by migrant workers that are about home and family as well as migratory experience of exile, loneliness, alienation, and isolation, the present study offers a different perspective of IMDW’s migratory experience working in Singapore that is depicted in the six selected poems through the postcolonial lens. Accordingly, it examines the migrant workers’ salient migratory experience of working in Singapore that, I argue, conveys voices of renegotiation for better IMDWs’ position as domestic workers and thus challenges certain stereotypes about them. The voice of renegotiation is expressed by vocalizing steadfastness and courage where subversion and confrontation against the dehumanization they oftentimes encounter can also be observed. These IMDWs through their poems are seen as a countering narrative about Indonesian domestic workers, and the notion of writing back is then solidly founded.
Efecto de la nutrición en el último tercio de la gestación de vacas de carne sobre el desarrollo de la progenie
Authors: Lenon Klein John , Martinho Adams Sander , Farias De Moura Amanda , Borchate Daniele , Alves Filho Dari Celestino , Pansiera Antunes Dieison , Moro Maidana Fabiana , Dos SantosCardoso Gilmar , Brondani Ivan Luiz , Gonçalves Gindri Ricardo
Published: July 2022

The restriction of nutrient intake by beef cows during pregnancy may influence the progeny postpartum growth potential, therefore, the objective of the present study was to evaluate the effects of nutritional restriction and adequate nutrition or overfeeding during the final third of gestation of the crossbred cows (Charolais x Nellore) kept in the Pampa biome, on the productive performance of the progeny up to 15 mo of age. Eighty-three (83) cows were divided into: control cows on natural pasture under nutritional restriction (RES); Supplementation to meet 100 % of requirements (REQ); Supplementation above requirements (HIGH). REQ and HIGH calves had higher body weight at birth compared to calves from RES cows (39.28, 39.13 vs 34.58 kg), without influences on postnatal performance. Females from REQ and HIGH cows presented better postnatal performance and consequently higher weight at 12 mo of age in compared to offspring RES cows (300.71 and 311.79 vs 259.47 kg). These female calves reached 60 % of early adult weight (358 and 345 vs 405 d) and had a higher percentage of breeding at twelve months of age (73.98 and 84.08 vs 34.08 %) than females from RES cows. Supplementing cows to meet 100% requirements, as well as overfeeding during the final third of gestation, improves offspring performance at twelve months of age, with males and females responding differently to maternal nutritional insults during this period.
Science communication in the face of skepticism, populism, and ignorance: what ‘Don’t Look Up’ tells us about science denial — and what it doesn’t
Authors: Mede Niels G.
Published: July 2022

‘Don’t Look Up’ tells the story of a team of astrophysicists whose efforts to warn politicians, media makers, and the public about an apocalyptic comet impact on planet Earth are undermined by fundamental skepticism toward their expertise. On the one hand, the film offers a rich portrayal of contemporary anti-science sentiments, their societal conditions, and the media and communication ecology surrounding them. But on the other hand, ‘Don’t Look Up’ ignores and exaggerates several facets of those sentiments and the communicative settings in which they spread. This commentary analyzes this contrast through a science communication lens: it scrutinizes the (mis)representation of science denial and science communication in ‘Don’t Look Up’ — and aims to inspire further debate about portrayals of anti-science phenomena and potential remedies within popular media.
Propuesta para el estudio histórico-semiótico de un testamento indígena del siglo XVII otorgado por un cacique de la provincia de Guane en el Nuevo Reino de Granada
Authors: Moreno González María Consuelo , Acevedo Tarazona Álvaro , Rodríguez Ruíz Jorge Ferdinando
Published: July 2022

Este escrito presenta algunos de los pasos por seguir para llevar a cabo un estudio histórico-semiótico de un fragmento del testamento del cacique de Coratá, fechado en 1649 y transcrito por fray Enrique Báez, con base en la crítica de fuentes —desde que el proceder analítico se instala en la disciplina historiográfica durante el siglo XIX— y el concepto de deconstrucción textual planteado por Jacques Derrida. En primer lugar, se hace un análisis histórico de la fuente con el fin de determinar las posibilidades investigativas que ofrece el documento testamentario que se estudia. En segundo lugar, se lleva a cabo un análisis semiótico de la huella o escritura del testamento, atendiendo a aspectos tales como el tipo de escritura, la huella del autor, la huella para el lector, las palabras que significan y simbolizan lo indio y lo indiano, la violencia escritural, las relaciones con el otro y el ser escrito.
Rastreando la flota del Berceau: metáforas orgánicas, epidemia y revolución en el Caribe transimperial de inicios del siglo XIX
Authors: Durango Loaiza Miguel
Published: July 2022

Este artículo analiza cómo a inicios del siglo XIX las autoridades en Nueva Granada y Venezuela percibieron las revoluciones en el Caribe francés. Para ello, rastrea la ruta de una flota francesa que partió de Martinica con el fin de vender más de doscientos prisioneros de guerra negros.  Contemporáneos describieron la llegada de esta expedición con analogías entre enfermedad, epidemia y revolución. Se argumenta que las metáforas orgánicas estructuraron las decisiones de las autoridades al rechazar o aceptar la trata de estos deportados. Asimismo, con evidencia de contrabando, se ilustra cómo hicieron uso selectivo de estas metáforas al tratar de prevenir nuevas rebeliones.