bluuebunny/crossref_metadata_2025 huggingface dataset:
Pathogenetic associations of indicators of prenatal screening of the firsr trimester of pregnancy with fetal growth retardation
Authors: Dektyarev Andrew A. , Kudryavtseva Elena V. , Kovalev Vladislav V.
Published: March 2022

Objective. To determine the relationship between the indicators of prenatal screening of the 1st trimester and the intrauterine growth retardation (IUGR).
Materials and methods. A prospective cohort study was carried out. Group 1 included 75 patients with fetal intrauterine growth retardation, group 2 414 women who gave birth to a live, full-term healthy baby with normal weight and height parameters. In all patients, the anamnestic parameters, indicators of PAPP-A, b-hCG, PlGF, thickness of the collar space and the pulsation index of the uterine arteries (PI UA) were compared.
Results. A number of significant differences in the anamnestic parameters were found between the groups. In group 1, multiparous women were met more often (16 % compared with 2.9% in group 2, p0.001), women after сesarean section (13.3% and 5.6%, respectively, p=0.013), women with a history of spontaneous and artificial abortions (46.7% and 34.1 %, p=0.036). In addition, in group 1, patients were more likely to have uterine myoma in 9.3 % versus 3.4% in group 2 (p=0.019). In group 1, during the first trimester screening, PAPP-A values ​​were lower 1.238 (0.682.05) IU/ml versus 2.25 (1.283.9) IU/ml in group 2 (p0.001), and PlGF 13.73 (10.2219.09) IU/ml versus 17.19 (12.125.38) in group 2 (p=0.002). There were no significant differences in the level of b-hCG. The average pulsation index of the uterine arteries, on the contrary, in group 1 in the first trimester was higher than in group 2 1.73 (1.422.11) and 1.55 (1.321.85), respectively (p=0.024).
Conclusions. Thus, a number of anamnestic data and screening indicators for the first trimester have a statistically significant relationship with the presence of IUGR of the fetus; therefore, these indicators can be used to assess the risk of this pregnancy complication.
Features of diagnostics and treatment of thyrotoxicosis in patients with severe comorbid pathology: clinical case
Authors: Styazhkina S. N. , Chernyadeva E. V. , Karmanova V. V. , Sazhina K. I. , Korobeinikov V. I.
Published: March 2022

Objective. To demonstrate the stages of diagnostics and successful treatment of thyrotoxicosis in a patient with severe comorbid pathology.

Materials and methods. A clinical case report of a patient with toxic goiter is presented.

Results. To specify the state of the thyroid gland, diagnostic and laboratory methods were applied: ultrasound examination (thyroid volume increased up to 182 cm2, isoechogenic nodule in the left lobe up to 1 cm, thyroid vascularization increased), spiral computed tomography (picture of diffuse nodular goiter with partial retrosternal location of the left thyroid lobe), hormone studies, the results of which revealed thyrotoxicosis. Thyroidectomy was subsequently carried out. Both thyroid lobes with isthmus were removed step-by-step with technical difficulties and high bleeding of tissues. The patient was discharged in 10 days in a satisfactory state.

Conclusions. Thyrotoxicosis is certainly a complex surgical pathology, in which correct assessment of the diagnosis by instrumental, clinical and laboratory methods is required, as well as successful surgical intervention. Not only normalization of hormonal status of a patient has to be taken into account, but also the possibility of disease relapse, contraindications due to age, physiological status, and comorbid abnormalities.
Modification of liver reparative regeneration in laboratory animals after partial hepatectomy
Authors: Maksimova A. Yu. , Valamina I. E. , Polushina L. G. , Tsvirenko S. V. , Bazarnyi V. V.
Published: March 2022

Objective. To investigate the effect of cytoflavin on the adaptive liver growth after partial hepatectomy (PH).

Materials and methods. An experimental study was conducted on 60 male white mice aged 78 months, weighing 2431 g. All animals were divided into three groups: group 1 intact mice; group 2 operated control mice, who received saline NaCl instead of the drug; group 3 the main group of animals, who underwent partial hepatectomy, after which they received сytoflavin. Partial hepatectomy was performed by Claudia Mitchell and Holger Willenbring technique (2008). The preparation cytoflavin (Russia) was injected intraperitoneally at a dose of 0.014 ml /10 g of body weight for 7 days once daily. Morphological and morphometric studies of hepatobiopsy specimens were conducted. Statistical analysis was carried out using the methods of nonparametric statistics.

Results. It was found that 3 days after PH, in the liver of animals of the main group, the number of dystrophically altered hepatocytes decreased by 25 times, the mitotic index increased against the background of the preserved radial-beam structure. There was an increase in the size of the cytoplasm and nucleus by 1.5 times relative to the intact group (p 0.05), that is associated with adaptive hypertrophy. At the same time, on the 3rd day, in the control group the number of dystrophically altered cells was several times higher than in the intact animals and was accompanied by an increase in the cytoplasm of hepatocytes as a result of vacuolar degeneration after PH.

Conclusions: The use of cytoflavin leads to an increase in the mitotic activity of the partially resected liver, while the level of binuclear cells decreases. The manifestations of hepatocyte dystrophy also decrease. Comparison of the dynamics of the morphometric parameters of hepatocytes in animals of the control group and those who received cytoflavin after PH suggests that the studied drug stimulates the recovery processes in the liver during induced regeneration.
Cellular composition of gastric glands in chronic gastritis among children
Authors: Akkuratova-Maksimova I. S. , Manyakina O. M. , Shkolina O. V.
Published: March 2022

Objective. To establish the features of the cellular composition of gastric mucosa glands in chronic Hp-associated gastritis among children to improve its diagnostics. Material and methods. Morphometric analysis of fundal and pyloric gland cell populations was performed in 214 children aged 615 years with Hp-associated chronic gastritis. For this purpose, the number of main, parietal, endocrine and additional cells was calculated in the materials of gastrobiopsy of the gastric mucosa, the result was expressed in (per 1000 epithelial cells). Results. It was found that as the severity of inflammation in the fundal glands increases, the number of main cells decreases, the number of parietal, accessory and especially endocrine cells grows. In the pyloric glands, a reduction of the parietal pool, a decrease in the population of additional cells and a sharp increase in endocrinocytes is registered. With a decrease in the severity of inflammation, positive changes in the cellular composition of the glands are observed, but its full normalization does not occur 6 months after the course of antihelicobacter therapy. A significant proportion of patients, shows morphological signs of gastric mucosa atrophy, which is associated with inflammation and is uncertain. Its presence does not significantly affect the cellular composition of the gastric glands, and the regression of the inflammatory process is accompanied by a decrease in the degree of atrophy or complete disappearance of signs of the latter. Conclusions. The addition of a standard study of gastrobioptates with a quantitative morphometric analysis of the cellular composition of the fundal and pyloric glands in chronic gastritis among children objectifies the data of morphological assessment of pathohistological picture of gastric mucosa.
Prospects of mathematical modelling for optimization of intersystem bypass grafting in congenital heart diseases among children
Authors: Sinelnikov Yu. S. , Arutyunyan V. B. , Porodikov A. A. , Biyanov A. N. , Pospelova N. S. , Kuchumov A. G. , Tuktamyshev B. S.
Published: March 2022

Objective. To study the facilities of mathematical modelling of the system aorta-shunt-pulmonary artery for assessing the efficiency of shunt functioning.
Materials and methods. The risk factors for the development of complications in 35 newborns and infants of the first year of life were analyzed while carrying out the procedure of the modified Blalock-Taussig shunt (MBTShunt). The study lasted from 2016 to 2021. The age median at the time of operation was 10 (Q1Q3: 3,530) days (from 1 to 180), the body mass median 3,0 (Q1Q3: 2,83,54) kg. The shunt size median was 3,5 mm (Q1Q3: 3,53,5), and the median of shunt size per 1 kg of body mass 1,11 (Q1Q3: 1,01,21) mm/kg.
The shunt size was increased for 4 out of 35 (11.4%) patients. As a result of cooperation with Perm Polytechnic University, in the frameworks of the program of hydrodynamic modelling evaluation, the data from 4 patients were processed mathematically to assess blood flowing through the MBTShunt.
Results. Three (9 %) out of thirty five patients died in 3 (Q1Q3: 2,511,0) (minmax 219) days because of cardiorespiratory decompensation. The only prognostically unfavorable risk factor for death was a large value of shunt size to body mass ratio (p=0.023). It was stated according to mathematical modelling data that the blood flow through the pulmonary arteries in all the analyzed types of shunts was not symmetric. An increase in the diameter of a shunt permits to improve a symmetry of blood flow through the left and right branches of the pulmonary artery.
Conclusions. The procedure of MBTShunt remains the procedure of high risk that is associated with a significant sickness rate and death rate in the early postoperative period. Mathematical modelling of the system aorta-shunt-pulmonary artery prior to the operation makes it possible to choose an optimal diameter of shunt and place of its implantation and will become one of the stages to personified surgery of congenital heart diseases in the future.
Efektivitas Karbon Aktif dalam Pembuatan Garam Rumput Laut Cokelat (Sargassum polycystum dan Padina minor)
Authors: Manteu Shindy Hamidah , Nurjanah Nurjanah , Abdullah Asadatun , Nurhayati Tati , Seulalae Anggrei Viona
Published: March 2022

Rumput laut cokelat memiliki potensi menjadi bahan baku garam diet untuk hipertensi, namun terdapat permasalahan dari produk akhir garam rumput laut yaitu aroma khas rumput laut (amis) yang masih kuat. namun Bahan alami yang dapat mencegah aroma ini salah satunya adalah karbon aktif. Tujuan penelitian adalah menentukan konsentrasi karbon aktif dalam proses pembuatan garam S. polycystum dan P. minor untuk menghasilkan garam yang bisa diterima oleh masyarakat. Metode yang digunakan dengan perlakuan konsentrasi karbon aktif berbeda (0%, 0,50%, 0,75%, 1%, 1,25%, 1,50% (b/v)) pada proses pembuatan garam, uji sensori aroma dan karakterisasi garam rumput laut. Karakteristik garam meliputi kadar mineral (Mg, Fe, Ca, Na, K), rasio Na:K, kadar NaCl dan aktivitas antioksidan. Konsentrasi karbon aktif optimum garam S. polycystum 1,50% dengan karakteristik Mg 29,24 mg/g; Fe 0,15 mg/g; Ca 27,66 mg/g; rasio Na:K 0.87 mg/g; NaCl 33.87%; aktivitas antioksidan  201,0 mg/L. Konsentrasi karbon aktif optimum garam P. minor yaitu 1% dengan karakteristik Mg 39,05 mg/g; Fe 0,03 mg/g; Ca 32,28 mg/g; rasio Na:K 1,97 mg/g; NaCl 28.34% dan aktivitas antioksidan111,39 mg/L.
Peningkatan Mutu Ikan Keumamah Loin Aceh dari Cakalang (Katsuwonus pelamis) menggunakan Daun Kari (Murraya koenigii)
Authors: Muhammad Nur Fajri  , Nurjanah Nurjanah , Uju Uju
Published: March 2022

Keumamah loin merupakan ikan kayu semi basah dengan pengeringan sinar matahari satu sampai dua hari, memiliki karakteristik tekstur daging yang agak lunak, aroma spesifik dan mudah mengalami kemunduran mutu. Daun kari (Murraya koenigii) banyak mengandung senyawa bioaktif yang berfungsi sebagai antioksidan. Tujuan penelitian ini adalah untuk menentukan pengaruh ekstrak daun kari, suhu, dan waktu pengeringan terhadap mutu keumamah loin dan efektivitas daun kari sebagai antioksidan. Penelitian ini menggunakan metode eksperimen rancangan acak lengkap faktorial (RALF) dengan taraf perlakuan ekstrak daun kari (0% dan 10%), suhu (40°С dan 60°С) dan waktu pengeringan (8 jam dan 12 jam). Parameter yang diamati kadar proksimat, nilai aktivitas air (aw) dan bilangan thiobarbituric acid (TBA). Hasil penelitian menunjukkan penggunaan daun kari, suhu, dan waktu pengeringan tidak berpengaruh terhadap kadar proksimat dan aktivitas air. Kadar protein diperoleh sebesar 28,22–32,1%, kadar lemak 2,72–4,60%, kadar abu 2,70–4,52%, kadar air 35,10–50,43% dan aktivitas air 0,84–0,87. Namun penggunaan daun kari berpengaruh terhadap bilangan TBA. Penggunaan daun kari 10%, suhu 40°С dan waktu 8 jam merupakan perlakuan terbaik karena memiliki bilangan TBA paling rendah yaitu sebesar 0,40±0,003 mg malonialdehida/kg. Penggunaan daun kari, suhu, dan waktu pengeringan dapat menghambat terjadinya proses oksidasi lipid pada produk keumamah loin.
Source Process Featuring Asymmetric Rupture Velocities of the 2021 Mw 7.4 Maduo, China, Earthquake from Teleseismic and Geodetic Data
Authors: Li Qi , Wan Yongge , Li Chengtao , Tang He , Tan Kai , Wang Dongzhen
Published: March 2022

On 21 May 2021, an Mw 7.4 left-lateral strike-slip earthquake occurred within the Bayan Har block in the Tibetan plateau. To learn about the source rupture process, we collected the teleseismic waveforms and utilized the backprojection method to investigate the rupture kinematics of the earthquake. The results indicate that the earthquake was a bilateral rupture event with asymmetric rupture velocities. The rupture velocity in the east of the epicenter was uniform and in the range of 2.72–3.67 km/s, whereas, in the west, it was in the range of 1.39–1.78 km/s in the first 20 km and then increased to 2.82–3.17 km/s. The slip distribution constrained by the Interferometric Synthetic Aperture Radar and Global Positioning System displacements clearly reveals kinematic coseismic slip in greater detail, which makes up for the limitations of the backprojection method. Two main asperities in the east verify the results of the backprojection method. The rupture depth in the west was slightly shallower than that in the east, which may be the reason for the asymmetry of rupture velocities. The initial rupture point was updated based on the asymmetric velocities and geodetic slip distribution. The multiple-point-source moment tensors based on the rupture velocities and new initial rupture point not only match the fault geometries determined by relocated aftershocks but also fit well with the released energy distribution, which proves the asymmetry of rupture velocities.
Citation Behavior Patterns and Sentiments towards Retracted Articles
Authors:   , Padova Kathleen Joan , Yan Erjia
Published: March 2022

Research articles are retracted for a number of reasons; yet often persist in the scientific community as evidenced by their continued reference in research. The persistence of retracted papers cited in current research undermines the foundation of confidence in the scientific community (Schneider, 2017). Retraction Watch estimates that 500 - 600 papers are retracted per year (Retraction Watch, 2016). Evidence of continued citation post-retraction can be counted in numerous publication databases and references; but does not convey the reasoning why researchers continue to reference these articles after retraction. We can reveal citation behavior patterns of authors or even groups of authors within a specific domain, say, by performing a text analysis of the context-providing sentences, or "citances" (Nakov, Schwartz, & Hearst, 2004). This is a relatively emergent analysis technique (Small, 2011) that is only beginning to develop classification schemes for these behaviors and theorizing reasons for these behaviors. The citation contexts to two papers retracted for different reasons (one for "unintentional error" the other for "misconduct and fraud") were examined and citation behaviors and sentiment were compared pre-retraction and post-retraction. A closer examination of post-retraction citations revealed that for one retracted paper ("misconduct and fraud"), the hypotheses of the citing papers changed and authors were stating the retracted status as a statement of fact and the subsequent consequences. For the second retracted paper ("unintentional error"), authors either ignored the retracted status, were unaware of the retraction, or only cited the portion that had not been disputed despite the full retraction of the paper. Despite the intention of withdrawing a paper and marking it no longer acceptable to the scientific community, the research shows that in addition to continued citation to a retracted paper as a statement of fact, authors have either found "valid" reasons for citing a retracted paper or a work-around to selecting portions of a retraction paper to reference. By uncovering the nature of this citing behavior, this research intended to illuminate how retracted articles continue to influence ongoing research post-retraction that can provide a framework upon which this issue can be addressed.
Effects of Probiotics, Prebiotics and Synbiotic Supplementation on Cognitive Impairment: A Review
Authors: Mukilan Murugan
Published: March 2022

Learning and memory formation are the two essential terms widely used in the field of cognition. Learning can be defined as acquiring new information or skills. Memory is formed due to changes in the neuronal system as a result of continuous stimulus exposure. Both learning and memory are fundamental processes that occur in all living organisms. Memory is broadly categorized into two different categories such as short-term memory (STM) and long-term memory (LTM). Compared to STM, LTM plays an essential role in the day-to-day activities of different living organisms. LTM requires RNA and protein synthesis-dependent mechanisms for memory storage, which lasts up to their lifetime. LTM formation is initiated when the neurotransmitters are released from the presynaptic neuron; further released neurotransmitters bind with their respective receptors present in the postsynaptic neuron and initiate the calcium influx. Calcium influx results in the further activation of molecules involved in the neuronal signaling pathway and results in memory formation. Present review reports the outcome of recent studies which showed that probiotic supplement is responsible for the retrieval of memory in case of memory impairment and its uses in the treatment of neurodegenerative disorders like mild cognitive impairment (MCI), Alzheimer's disease (AD).  Recent research studies were shown that probiotic microorganisms may positively regulate neurotransmitter release and increase the calcium influx, brain derived neurotrophic factor (BDNF), and N-methyl-D-aspartate receptor (NMDAR) and plays a pivotal role in the LTM formation in gut-dysbiosed & memory-impaired animal models.
Evaluations of Morpho-Physiological Variances in Soybean Varieties under Low Water Conditions
Authors: Mangena Phetole , Mabulwana Paseka Tritieth
Published: March 2022

This study used pot experiments with a completely randomized design (CRD) in triplicates to evaluate physiological and morphological attributes used for the characterization of drought stress tolerance in six soybean varieties (Knap, Mopani, LS677, LS678, Pan1564, and Sonop). Growth and physiological parameters analyzed in this study, included plant height, number of flowers, number of pods, seed number per pod, leaf surface area (LSA), grain yield, and total phenolics, flavonoids, ureides as well as antioxidant activity. Low water conditions caused varied negative effects depending on the level of stress on both morphological and physiological responses of the plants. Enhanced secondary products (ureides, total phenolic, and flavonoid content) were observed in plants subjected to severe water stress, in addition to reduced photosynthetic components and percentage grain yields. However, soybean variety Sonop, LS677, and LS678 consecutively, induced high secondary metabolite accumulations and antioxidant activity possibly preventing the occurrence of excessive oxidative stress damage caused by water shortage. The performance of LS varieties, Knap and Sonop were more prominent than Mopani and Pan1564. Results showed potential tolerance to stress in Sonop, LS678 and LS677, attributed to the strong free radical scavenging activity and maintenance of photosynthetic pigments used to achieve sufficient growth balance in plants.
Determination of Trace Elements in Sediments Samples by Using Neutron Activation Analysis
Authors: Krishnan Kumar , Saion Elias B. , CK Yap , Chong Mee Yoke , Nadia A. S.
Published: March 2022

The Juru River is a highly industrialized, urbanized, and agricultural catchment. This study aimed to investigate trace elements in Juru mangrove sediments, including geochemical baselines and enrichment. Sediment was collected from the mangrove in Juru, Penang, Malaysia. A total of eight target elements was examined.  Instrumentation activation analysis (INAA) was used to determine the concentration of Fe, V, Cr, Zn and Co. Atomic absorption spectrometry (AAS) was used to determine the concentration of elements that not detectable by INAA (Cd, Pb, and As). In both methods, validated reference material studies were used for validation of the methodology. Metal pollution was estimated using the Enrichment Factor (EF), Geoaccumulation Index (Igeo), Contamination Factor (CF), and Pollutant Load Index (PLI). The EF, Igeo, and CF ranges from 0.45–7.96, -2.18 – 1.95, and 0.33–5.83 respectively. The order of accumulation of the elemental concentration found was Fe > Zn> Cr > V > Pb > As > Co >Cd. The computed mean value of PLI exceeds the unit (PLI > 1).
Analysis of Social Capital Effect in the Joint Liability Group on the Performance of Sharia Cooperatives in Indonesia
Authors: Yulita Nurma , Pratiwi Amelia
Published: March 2022

This investigation aims to analyze the impact of the joint liability model on the sharia cooperatives’ performance in Indonesia. The respondents are several group lending members of sharia cooperatives in Java, the center of sharia cooperatives in Indonesia. This study utilized the purposive sampling method to select samples conducted in April 2021. Data collection was carried out by distributing online and offline questionnaires to several sharia cooperatives utilizing the joint liability model. Data from 98 respondents were further analyzed by PLS-SEM analysis. The results unveiled that joint liability, which was influenced by indicators of trusts, norms, and networks, had a positive and significant effect on sharia cooperatives’ performance as measured by members’ satisfaction and loyalty. Thus, sharia cooperatives can take advantage of and maintain the joint liability model based on trusts, norms, and networks. The rationale is that the joint liability application has followed cooperative principles: the principle of kinship and cooperation. In addition, such a model has proven to increase the loyalty and satisfaction of sharia cooperative members.
Willingness to Pay for Destination Quality Improvement: Case Study of Baru Beach, Yogyakarta
Authors: Setiawan Ferry , Saptutyningsih Endah
Published: March 2022

This study aims to analyze the willingness to pay visitors for the quality improvement of Baru Beach. The respondents of this research are visitors in Baru Beach. This study uses the contingent valuation method (CVM). Accidental techniques were used to collect data from 150 tourists in Baru Beach. This paper found that the average value of willingness to pay (WTP) is IDR15,000 obtained using dichotomous choice. In addition, variables of age, income, education level, frequency of visits, and visitor perceptions were positive to WTP. Distance and marital status have no significant effect.
Clinical characteristics of ocular toxocariasis in adults in north China
Authors:   Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China, Hu Xiao-Feng , Kang Hao ,   Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China, Wang Hui ,   Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China, Liu Xu-Hui ,   Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450046, Henan Province, China, Tao Yong ,   Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
Published: March 2022

AIM: To investigate the clinical features of adult patients with ocular toxocariasis (OT) in north China and to diagnose adults OT patients in early stage.
METHODS: Clinical data of 24 adults with OT were retrospectively analyzed. Slit lamp photographs and fundus photographs and other imaging examinations of all the patients were reviewed. A questionnaire concerning the pet ownership and place of residence was completed to investigate the possible infection origin. Descriptive statistical analyses were performed on the demographic data, clinical features, funduscopic findings and ELISA results.
RESULTS: Among the 24 patients diagnosed with OT by Toxocara IgG antibody in intraocular fluid, 16 (66.7%) eyes were right eye. The onset age of 12 eyes (50.0%) was between 30 and 40 years old, and 21 (87.5%) eyes were of peripheral granuloma type. The most common sign was vitreous opacity. Granulomas were detected in all the eyes, and 20 (83.3%) patients resided in rural area. In 4 patients, the concentration of anti-Toxocara antibody both in anterior humor and in vitreous humor were detected, and the results showed the concentration in vitreous humor was much higher than aqueous humor.
CONCLUSION: Our study analyzes the clinical manifestation of OT in adults, which may have been under-recognized before. Eye side, residence, and detection of granuloma may help us in diagnosis of OT in patients with monocular vitreous opacity. For adult patients with presumed OT, negative results of anti-Toxocara antibody in anterior humor cannot rule out the possibility of OT, further detection of vitreous humor is suggested for final diagnosis.
Plasma and aqueous humor levels of adiponutrin and pannexin 1 in patients with and without diabetic retinopathy
Authors:   Ophthalmology Clinic, Elazığ City Hospital, Elazig 23200, Turkey, Gül Fatih Cem , Çelik Fatih ,   Ophthalmology Clinic, Elazığ City Hospital, Elazig 23200, Turkey, Aydin Süleyman ,   Department of Biochemistry, Firat University, Elazig 23119, Turkey, Akkoç Ramazan Fazil ,   Department of Anatomy, Firat University, Elazig 23119, Turkey
Published: March 2022

AIM: To evaluate plasma and aqueous levels of adiponutrin and pannexin 1 in patients with and without diabetic retinopathy.
METHODS: The study included three age and gender-matched groups of 20 cataract patients with no diabetes or additional disease (Group C), 20 cataract patients with diabetes and no retinopathy (Group DM+C), and 20 cataract patients with diabetic retinopathy (Group DR+C). All the patients were examined with respect to body mass index (BMI), fasting plasma glucose, hemoglobin A1c (HbA1c), and lipid profile. Phacoemulsification and intraocular lens (Phaco+IOL) implantation were performed to all patients in all the groups, and aqueous samples were taken during the operation. The plasma and aqueous adiponutrin and pannexin 1 levels were analyzed using enzyme-linked immunosorbent assays.
RESULTS: A statistically significant difference was determined between the groups with respect to BMI, fasting plasma glucose, and HbA1c levels (P<0.05 for all parameters tested). The plasma adiponutrin levels of Group DR+C were statistically significantly lower than those of Group C and Group DM+C (P<0.001, P=0.004). No statistically significant difference was determined in the aqueous adiponutrin levels in three groups. The plasma pannexin 1 levels of Groups DM+C and DR+C were statistically significantly lower than those of Group C (both P=0.001). The aqueous pannexin 1 levels of Group DR+C were statistically significantly higher than those of Group C and Group DM+C (P=0.001, P<0.001).
CONCLUSION: Adiponutrin and pannexin 1, which play an important role in the pathophysiology of diabetes and obesity, and have a regulatory role in hyperglycemia and insulin resistance. The measurement of adiponutrin and pannexin 1 levels may support clinicians in determining the risk of DR development.
Gender as an effect modifier in the relationship between hypertension and reticular pseudodrusen in patients with early or intermediate age-related macular degeneration
Authors:   Department of Ophthalmology, University of Colorado School of Medicine, Aurora, CO 80045, USA, Gelinas Nathaniel , Mathias Marc T. ,   Department of Ophthalmology, University of Colorado School of Medicine, Aurora, CO 80045, USA, Palestine Alan G. ,   Department of Ophthalmology, University of Colorado School of Medicine, Aurora, CO 80045, USA, Mandava Naresh ,   Department of Ophthalmology, University of Colorado School of Medicine, Aurora, CO 80045, USA, Christopher Karen L ,   Department of Ophthalmology, University of Colorado School of Medicine, Aurora, CO 80045, USA, Patnaik; University of Colorado Retina Research Group Jennifer L. ,   Department of Ophthalmology, University of Colorado School of Medicine, Aurora, CO 80045, USA
Published: March 2022

AIM: To determine whether the prevalence of treated hypertension is higher among males or females with early/intermediate (e/i) age-related macular degeneration (AMD) with and without bilateral reticular pseudodrusen (RPD).
METHODS: Retrospective review of the records of patients with e/iAMD who were recruited into the University of Colorado AMD registry between July 2014 and November 2019. Images were classified using the Beckman Initiative criteria and presence/absence of RPD. Patients were categorized into three groups: 1) e/iAMD with RPD; 2) e/iAMD without RPD; 3) control patients who did not have AMD. Multinomial logistic regression analysis was used for adjusted analysis with odds ratios (OR) and confidence intervals (CI).
RESULTS: There were 260 patients with e/iAMD of which 101 had bilateral RPD and 159 had no RPD, and 221 controls. Overall, 62% of patients were female and the three groups did not differ by gender. When stratified by gender, the female e/iAMD/RPD group had a higher prevalence of hypertension, 64.1% vs 45.2% for controls, OR=2.2 (95%CI: 1.2-4.0). The frequency of hypertension in the e/iAMD/no RPD group was 54.1% and did not significantly differ from the control group. Among males, prevalence rates of treated hypertension did not differ. There is a significant interaction of hypertension and gender for the e/iAMD/RPD group such that women with e/iAMD who had RPD were significantly more likely to have hypertension (P=0.042). This relationship was not significant in the e/iAMD/no RPD group (P=0.269).
CONCLUSION: Among females treated hypertension is significantly higher among e/iAMD/RPD patients, whereas for males there is no significant association.
Effect of oral citicoline therapy on retinal nerve fiber layer and ganglion cell-inner plexiform layer in patients with primary open angle glaucoma
Authors:   Department of Ophthalmology, Training and Research Hospital, Ordu University, Ordu 52000, Turkey, Sahin Asena Keles , Uzun Aslihan ,   Department of Ophthalmology, Training and Research Hospital, Ordu University, Ordu 52000, Turkey
Published: March 2022

AIM: To evaluate the short-term effects of oral citicoline therapy on the retinal nerve fiber layer (RNFL) and the macular ganglion cell-inner plexiform layer (mGCIPL) in patients with primary open angle glaucoma (POAG).
METHODS: Fifty-four eyes of 54 patients with POAG glaucoma included in the study. In addition to a topical hypotensive, 250-mg oral citicoline was administered to 27 patients, while 27 patients were assigned as the control group. RNFL and mGCIPL values were measured using optical coherence tomography (OCT) at 1d before treatment and 3mo after the initiation of treatment. At the third month visit, citicoline treatment was discontinued and drug-free control (wash-out) measurements were obtained at the fourth month in citicoline group.
RESULTS: The average RNFL thickness was significantly higher at month 3 than the baseline (P=0.038) in citicoline group. However, this improvement partially regressed after a 1-month wash-out period. No statistically significant changes in RNFL were observed in the superior, nasal, temporal and inferior quadrants at months 3 and 4 (P>0.05). The change in the average and inferior quadrant RNFL thickness in the citicoline group at 3mo was significantly greater than the control group (P=0.006 and P=0.014, respectively). There were no significant differences between the groups according to the change in mGCIPL thickness and the superior, nasal and temporal quadrant RNFL thickness (P>0.05).
CONCLUSION: With oral citicoline treatment, the loss in the average RNFL is prevented in POAG patients in the short-term. Study data show that citicoline may have a significant impact on slowing glaucoma progression, which could have a potential neuroprotective effect.
What Do You Mean When You Say You Like This Painting? Oculomotor Indices of Processes Involved in Aesthetical Appreciation
Authors: Francuz Piotr , Jankowski Tomasz , Augustynowicz Paweł
Published: March 2022

This study aims to verify the hypotheses concerning emotional and cognitive predictors of aesthetic judgments, operationalized by instructions for viewing paintings from different perspectives (emotions and feelings, empathy, the captured moment, important elements, title, and mystery). Two eye movement parameters: fixation duration average and scan path length, estimated based on data recorded during viewing paintings, were analyzed. The extent to which the parameters of eye movement while performing different instructions predict the same parameters during the aesthetic assessment task was investigated. It was assumed that similar parameters of eye movements are indicators of similar mental processes, activated under different instructions. The viewing time window and expertise of participants were independent variables. Data were analyzed by multilevel modeling. The results showed that at the early stage of viewing a painting, instructions that activate emotional processing (regardless of expertise), better predict the aesthetic evaluation of a painting than instructions activating cognitive processes. At this stage, it was also found that the eye movement parameters, during the performance of instructions that activate cognitive processing, better predict the aesthetic evaluation of paintings only in the group trained in visual arts. At the later stage of viewing paintings, instructions activating cognitive processes turned out to be more reliable predictors of eye movement parameters during the aesthetic evaluation task than instructions activating emotional processes in both groups of participants. The results of the experiment were confronted with the existing models of perception of art and aesthetic experience.
MicroRNA-151 regulates the growth, drug sensitivity and epithelial mesenchymal transition of human glioma cells by targeting profilin 2
Authors: Zhang Wenxue , Niu Hanhong , Wang Rongze , Liu Chenchao , Wang Yi
Published: March 2022

The microRNA-151 (miR-151) has been reported to be involved in the growth, development, and tumorigenesis of different types of human cancers. This study was designed to unravel the role and therapeutic potential of miR-151 in glioma. The results showed glioma was found to be associated with significant (P<0.05) downregulation of miR-151. Low expression of miR-151 was also associated with poor survival of the glioma patients. Overexpression of miR-151 resulted in a significant (P<0.05) decline of glioma cell proliferation and colony formation. The sensitivity of the glioma cells to adriamycin also increased significantly (P<0.05) upon miR-151 overexpression. Additionally, overexpression of miR-151 also suppressed the migration and invasion of the human glioma cells. This was also associated with alteration in the expression of epithelial mesenchymal transition proteins. The expression of E-cadherin was increased while as that of N-cadherin, vimentin, and Snail was considerably decreased upon miR-151 overexpression. Bioinformatic analysis and ducal luciferase assay showed miR-151 targets profilin 2 (PFN2) in human glioma cells. The expression of PFN2 was found to be significantly (P<0.05) upregulated in human glioma tissues cells and cell lines. Nonetheless, the PFN2 expression was considerably suppressed upon miR-151 overexpression. Knockdown of PFN2 resulted in decrease of glioma cells proliferation. In contrary, overexpression of PFN2 could avoid the tumor-suppressive effects of miR-151. Taken together, present study points towards the tumor-suppressive effects of miR-151 and prospective therapeutic implications in human glioma.
Stylistic features and genre representations of religious vocabulary in contemporary Russian language
Authors:   Kazan (Volga region) Federal University, Guo Xueyao
Published: March 2022

The article observes stylistic features and genre representations of religious vocabulary in contemporary Russian language. The study of the development of terminological systems in certain areas of knowledge and their role in the development of a language is one of the most important problems in modern linguistics. The solution to this problem is to study the great variety of sources of spiritual, academic, business, journalistic and other areas of human activity. Religious vocabulary is the richest layer of the Russian language. The study of the use of religious terminology in the functional styles of Russian makes it possible to clearly identify the psychological, categorical and subject meanings of this type of vocabulary in the system of indigenous language of Russians. The aim of this research is to study styles and genres in which religious lexemes are found in modern Russian. This is explained by the fact that language and religion are closely related. The influence of religion on language is an indisputable fact, because in every religion there is a number of lexemes that relate only to a particular faith. At the same time, some religious lexemes have become common and formed a part of the active vocabulary of Russians. That is why we observe the following situation in the Russian language: religious terms appear in all styles of speech.
Przeciwdziałanie negatywnym skutkom gospodarczym pandemii koronawirusa. Analiza porównawcza działań wybranych państw
Authors: Czajkowska Małgorzata
Published: March 2022

Addressing the negative economic impacts of a coronavirus pandemic. A comparative analysis of the actions of selected countries Purpose: The purpose of the chapter is to assess the extent of actions taken by selected countries to reduce the negative economic impact of the COVID-19 pandemic and the scale of resources used for these actions. Design/methodology/approach: Models of market economy are presented and anti-crisis measures taken by Poland, Germany, USA, China and Sweden are described. The amount of money spent on these measures is also presented. Findings: Germany was the country with the largest budget expenditure to counteract the negative economic effects of the pandemic. Contrary to assumptions, Poland was not the country with the lowest budget expenditure. Germany and Sweden introduced the largest number of instruments supporting entrepreneurs. Germany’s aid package offered more support on taxes, while Sweden’s package offered more support on employment. The United States offered the narrowest aid package, which is related to the economic model adopted in this way. Originality and value: The chapter contains an analysis of anti-crisis measures (aid packages) undertaken by Poland, Germany, the United States, China and Sweden and information on the scale of financial involvement of these countries in helping entrepreneurs. There are no studies in the literature that directly compare the forms of aid used and their volume between the countries. The chapter provides data to assess countries’ involvement in combating the economic impact of the pandemic depending on their economic model. The collected data also has theoretical implications.
Sytuacja mieszkaniowa Polaków i działania organów publicznych w celu jej poprawy
Authors: Drożdżyński Mikołaj
Published: March 2022

Housing situation of Poles and activities of public authorities to improve it Purpose: The purpose of this study is to assess the housing situation of Poles and to present activities of public entities, especially communes, undertaken to improve it. Design/methodology/approach: Secondary data was presented showing the number and ownership structure of dwellings and the demand for dwellings in Poland. The data comes from the Central Statistical Office and the Ministry of Development. The previous activity of municipalities in developing the local housing market is also discussed and the concept of social housing initiatives is characterized. Findings: Despite the record number of housing units completed in recent years, there is still a shortage of housing units, which negatively affects the socio-economic development of the state. The main barrier to access to housing is its price and the high growth rate of 1 m2 of space. Municipalities could more actively answer the housing needs of citizens by creating social housing initiatives, i.e. not for profit companies building rental housing with moderate rent. Originality and value: State housing policy has been questioned. The provision of own contribution by the state for certain social groups may lead to an increase in real estate prices, because with their limited supply the demand for these apartments and the price of 1 m2 of space rises. It is postulated to increase the activity of municipalities in the housing market. This may consist in creating social housing initiatives, i.e. not for profit companies building apartments for rent with moderate rent (lower even by 50% in relation to the market rent).
Historyczne uwarunkowania różnic w rozwoju polskich regionów i wybrane problemy finansowania publicznego jako bariery realizacji celów zrównoważonego rozwoju
Authors: Jędrzejewska Oliwia , Ziółkowska Julia
Published: March 2022

Historical determinants of differences in development of Polish regions and selected problems of public financing as a barrier to realization of sustainable development goals Purpose: The aim of this study is to indicate the role of the state in the pursuit of sustainable development of Poland. Design/methodology/approach: The authors assume that historical factors underlie the differentiated development of Polish regions. A critical review of the literature on historical determinants of development of Polish regions was conducted. International legal conditions calling on Poland to take action to reduce adverse climate change are presented. The amount of state budget expenditure on tasks related to sustainable development of the country is discussed. Secondary data from the reports of the Council of Ministers were used. Findings: Differences in the level of the development of Polish regions are historically determined. Compared to other countries, the degree of Poland’s achievement of sustainable development goals is satisfactory, as it ranks 23rd in the world ranking (out of 193 possible places). Budget expenditures on tasks contributing to the achievement of sustainable development goals are relatively small. Originality and value: It is pointed out that in the past, the amount of spending on state development financing has varied. Historical conditions continue to affect the uneven development of individual regions. The authors suggest that the unsatisfactory level of the development of some regions is due not so much to the lack of access to funding sources, but to the mentality of people living in these areas.
Análise do módulo de elasticidade e permeabilidade de argamassas de rejuntamento para uso em ambientes internos úmidos
Authors: Motta Larissa Maffioleti , Antunes Elaine Guglielmi Pavei , Roman Humberto Ramos , Vitali Lucas Lopes
Published: March 2022

As juntas são pequenos espaços deixados entre as placas cerâmicas, conforme Pilla (2013), elas são indispensáveis, pois representam um importante elemento na estabilidade no sistema de revestimento cerâmico. A argamassa de rejuntamento, também chamada de rejunte, refere-se a argamassa utilizada para preencher essas juntas, após o assentamento. Em ambientes úmidos o rejunte fica exposto à grandes variações volumétricas devido as movimentações de origem higroscópicas, portanto deve apresentar características de flexibilidade que auxiliem no alivio do estado de tensões do revestimento e de impermeabilidade, para que, assim, não haja perdas de desempenho. O referido estudo tem por objetivo analisar a permeabilidade e o módulo de elasticidade de argamassas de rejuntamento, compostas por cimento Portland, de diferentes fabricantes.
Análise do comportamento mecânico de vigas de madeira maciça com sistema de protensão por cabos de aço
Authors: Wanderlind Augusto , Bratti Naiara , Vito Marcio
Published: March 2022

Por ser um material em abundância e de baixo custo, tem-se procurado várias alternativas para abranger a utilização da madeira para fim estrutural na construção civil, uma ideia inovadora, é a associação do sistema de protensão à viga de madeira maciça. No presente trabalho foi desenvolvido um sistema de protensão em vigas de madeira maciça da espécie Eucalyptus Saligna, com cabos de aço, de forma a fazer um comparativo de comportamento em relação ao suporte de carga através de ensaios de flexão estática a quatro pontos quando comparados com vigas de madeira maciças sem reforço. Estes ensaios foram realizados no Parque Científico e Tecnológico – Iparque, UNESC. Foram utilizadas amostras de madeira maciça e amostras com protensão, todas elas com seção transversal de 6,5x14x210 cm, e vão teórico de 200 cm, onde foi possível obter as cargas máximas solicitadas e o deslocamento vertical até a ruptura das peças. Com os resultados obtidos foi possível verificar um acréscimo na capacidade de carga para as vigas com reforço de cabo de aço de 90,41%, porém ainda sendo necessário um aperfeiçoamento na montagem do sistema de maneira a obter resultados ainda melhores.
Projeto de Extensão Reconstruindo a Cidadania
Authors: Dare Mônica Elizabeth , Pirolla Douglas Leffa , Prado Rafael José , Zancan Evelise Chemalle
Published: March 2022

Projeto de Extensão Reconstruindo a Cidadania Daré, Mônica Elizabeth[1]Pirolla, Douglas Leffa[2]Prado, Rafael José[3]Zancan, Evelise Chemalle[4]1- IntroduçãoSegundo Paiva e Salgado (2003) a educação dos operários, sem dúvida alguma, contribui para que eles tenham condições de assimilar novas técnicas, aceitando avanços nas existentes, diminuindo os erros de execução, que geram não conformidades, e, portanto, o retrabalho, os acidentes de trabalho e o desperdício.  Diante destas questões o objetivo deste projeto é promover a preparação e a capacitação para as pessoas em vulnerabilidade social e/ou trabalhadores na construção civil, nas categorias profissionais pertinentes às equipes de obras, proporcionando oportunidades de integração e compreensão do ambiente de trabalho, para melhor inserção no meio social e do trabalho. O projeto de extensão Reconstruindo a Cidadania desenvolve suas atividades desde 2010 em parcerias com várias entidades, instituições e empresas. A empresa Farben Tintas S.A. constitui-se parceira permanente do projeto, e como outras parcerias, em várias edições anteriores, têm-se a Prefeitura Municipal de Criciúma, a Prefeitura Municipal de Jacinto Machado, a Acijam (Associação Comercial de Jacinto Machado), a Associação Beneficente ABADEUS, e a Prefeitura Municipal de Cocal do Sul. A partir do ano de 2017 a entidade Bairro da Juventude tornou-se parceira do projeto. Destaca-se dentro do projeto o módulo de pintura imobiliária e moveleira que promove aos participantes a preparação e a capacitação para atividades de pintura na construção civil e na indústria de móveis.[1]Especialista, Unesc, dare@terra.com.br[2]Acadêmico, Unesc, dpirolla@unesc.net[3]Acadêmico, Unesc, rafael-do-p@hotmail.com[4]Mestre, Unesc, ecz@unesc.net