bluuebunny/crossref_metadata_2025 huggingface dataset:
Angiotensin II-related activation of scleral fibroblasts and the role of retinal ganglion cell death in glaucoma
Authors: Oh Si Eun , Kim Jie Hyun , Shin Heejong , Kim Seong Ah , Park Chan Kee , Park Hae Young Lopilly
Published: January 2023

We identify the angiotensin II (AngII)-associated changes in the extracellular matrix (ECM), and the biomechanical properties of the sclera after systemic hypotension. Systemic hypotension was induced by administering oral hydrochlorothiazide. AngII receptor levels and ECM components in the sclera and biomechanical properties were evaluated by stress–strain relationship after systemic hypotension. The effect of inhibiting the AngII receptor with losartan was determined in the systemic hypotensive animal model and the cultured scleral fibroblasts from this model. The effect of losartan on retinal ganglion cell (RGC) death was evaluated in the retina. Both AngII receptor type I (AT-1R) and type II (AT-2R) increased in the sclera after systemic hypotension. Proteins related to the activation of fibroblasts (transforming growth factor [TGF]-β1 and TGF-β2) indicated that transformation to myofibroblasts (αSMA), and the major ECM protein (collagen type I) increased in the sclera after systemic hypotension. These changes were associated with stiffening of the sclera in the biomechanical analysis. Administering losartan in the Tenon’s tissue significantly decreased the expression of AT-1R, αSMA, TGF-β, and collagen type I in the cultured scleral fibroblasts and the sclera of systemic hypotensive rats. The sclera became less stiff after the losartan treatment. A significant increase in the number of RGCs and decrease in glial cell activation was found in the retina after the losartan treatment. These findings suggest that AngII has a role in scleral fibrosis after systemic hypotension and that inhibiting AngII could modulate the tissue properties of the sclera resulting in the protection of RGCs.
Cooperative phototherapy based on bimodal imaging guidance for the treatment of uveal melanoma
Authors: Huang Tong , Xu Xinzhi , Cheng Chen , Wang Jianxin , Yang Liping
Published: January 2023

Background
Uveal melanoma (UM) is the most common primary intraocular malignant tumor in adults, prone to metastasis and high mortality. Currently, eyeball enucleation commonly used in clinics will lead to permanent blindness and mental disorders. Thus, new methods are urgently needed to diagnose and treat UM early to preserve patients' vision.
Methods and results
Herein, multifunctional nanoparticles (NPs) were synthesized by loading chlorin e6 (Ce6) in poly-lactic-co-glycolic acid (PLGA) NPs and wrapping FeIII-TA on the outside (designated as FTCPNPs). Then, the synergistic photothermal therapy (PTT) and photodynamic therapy (PDT) antitumor effects of FTCPNPs excited by near-infrared (NIR) laser were evaluated. Moreover, we verified the mechanism of synergistic PTT/PDT leading to mitochondrial dysfunction and inducing tumor cell apoptosis. Additionally, FTCPNPs can be used as excellent magnetic resonance (MR)/photoacoustic (PA) imaging contrast agents, enabling imaging-guided cancer treatment. Finally, The NPs have good biological safety.
Conclusion
This noninvasive NIR light-triggered cooperative phototherapy can easily penetrate eye tissue and overcome the disadvantage of limited penetration of phototherapy. Therefore, cooperative phototherapy is expected to be used in fundus tumors. This treatment model is applied to UM for the first time, providing a promising strategy and new idea for integrating the diagnosis and treatment of UM.
Impact of early initiation of renin-angiotensin blockade on renal function and prognosis in patients with hypertensive emergency: A retrospective cohort study
Authors: Endo Keita , Hayashi Koichi , Hara Yuki , Miyake Akihiro , Takano Keisuke , Horikawa Takehiro , Yoshino Kaede , Sakai Masahiro , Kitamura Koichi , Ito Shinsuke , Imai Naohiko , Suzuki Toshihiko , Fujitani Shigeki
Published: January 2023

Background
Hypertensive emergency is a critical disease that causes multifaceted sequelae, including end-stage kidney disease and cardiovascular disease. Although the renin-angiotensin-aldosterone (RAA) system is enormously activated in this disease, there are few reports that attempt to characterize the effect of early use of RAA inhibitors (RASi) on the temporal course of kidney function.
Methods
This retrospective cohort study was conducted to clarify whether the early use of RASi during hospitalization offered more favorable benefits on short-term renal function and long-term renal prognosis in patients with hypertensive emergencies. We enrolled a total of 49 patients who visited our medical center with acute severe hypertension and multiple organ dysfunction between April 2012 and August 2020. Upon admission, the patients were treated with intravenous followed by oral antihypertensive drugs, including RASi and Ca channel blockers (CCB). Kidney function as well as other laboratory and clinical parameters were compared between RASi-treated and other antihypertensive drugs-treated group over 2 years.
Results
Antihypertensive treatment effectively reduced blood pressure from 222 ± 4/142 ± 3 to 140 ± 3/87 ± 2 mmHg at 2 weeks and eGFR was gradually restored from 33.2 ± 3.3 to 41.1 ± 4.1mL/min/1.73m2 at 1 year. The renal effect of antihypertensive drugs was particularly conspicuous when RASi was started in combination with other conventional antihypertensive drugs at the early period of hospitalization (2nd day [IQR: 1-5.5]) and even in patients with moderately to severely diminished eGFR (< 30 mL/min/1.73 m2) on admission. In contrast, CCB modestly restored eGFR during the observation period. Furthermore, renal survival probabilities were progressively deteriorated in patients who had manifested reduced eGFR (< 15mL/min/1.73 m2) or massive proteinuria (urine protein/creatinine ≥ 3.5 g/gCr) on admission. Early use of RASi was associated with a favorable 2-year renal survival probability (0.90 [95%CI: 0.77-1.0] vs. 0.63 [95%CI: 0.34–0.92] for RASi(+) and RASi(-), respectively, p = 0.036) whereas no apparent difference in renal survival was noted for CCB, β-blocker, α-blockers, or diuretics.
Conclusions
Early use of RASi contributes to the renal functional recovery from acute reduction in eGFR among patients with hypertensive emergencies. Furthermore, RASi offers more favorable effect on 2-year renal survival, compared with other antihypertensive drugs.
Various effects of 11,12 EET rescue wound healing in a combined model of diabetes and ischemia
Authors: Sommer Katharina , Jakob Heike , Lettenmeier Theresa , Henrich Dirk , Sterz Jasmina , Marzi Ingo , Frank Johannes
Published: January 2023

Chronic non-healing wounds caused by diabetes and ischemia. We analyzed the effects of 11,12 Epoxyeicosatrienoic acid (EET) in a combined model of hyperglycemia and ischemia in mice.
Hyperglycemia was induced by Streptozotozin 2 weeks prior to wounding. 3 days before wound creation 2 of the 3 suppling vessels of the moue ear were cautherized for ischemia. Either 11,12 EET or solvent for control was applied. Wound closure as well as TNF-α, TGF-β, SDF-1α, VEGF, CD31, and Ki67 was measured.
The wounds closed on day 14.4 ± 0.4 standard deviation (SD). 11,12 EET treatment enhanced healing to 9.8 ± 0.6 SD. TNF-α level was augmented on day 9 compared to control and receded on day 18. TGF-β seemed to be elevated all days observed after 11,12 EET treatment. SDF-1α was enhanced on day 6 and 9 by 11,12 EET, and VEGF on day 6 and 18 as well as CD13 on day 3, 6, and 18. 11,12 EET did not alter Ki67.
11,12 EET are able to rescue deteriorated wound healing in a combined model of hyperglycamia and ischemia by resolution of inflammation, augmentation of neovascularization and increasing expression of TGF-β as well as SDF-1α.
WITHDRAWN: Anticorrosive concert of expired drug acts as novel and potent inhibitor for deterioration of Low carbon steel in acidic Environment
Authors: M Gunasekaran , P Srinivasan
Published: January 2023

Frisium anticorrosive activity in corrosive environments was investigated. The performance of the inhibitor as studied by weight loss method along with surface morphological experiments SEM and AFM. The drug showed higher anti corrosive activity 91.66 % in 500 ppm, the above results further showed the scale of inhibition is depends on the concentration of frisium by increasing the concentration the inhibition efficiency of the drug as increased as well as increasing the temperature the inhibition rate was decreased. Impedance results showed charge transfer takes place between the metal surface and acid solution and frisium performed as a mixed type of inhibitor has proven by the polarization measurements. The drug was heavily adsorbed on the low carbon steel surface and is revealed by SEM and AFM studies. By analyzing the DFT values which leads to the accumulation of a thin layer on the metal surface. IR spectral studies have also confirmed the drug's adsorption on the metal surface.
Structure based High-Throughput Virtual Screening, Molecular Docking and Molecular Dynamics Study of anticancer natural compounds against Fimbriae (FimA) protein of Porphyromonas gingivalis in oral squamous cell carcinoma
Authors: Singh Suchitra , Yadav Piyush Kumar , Singh Ajay Kumar
Published: January 2023

Oral cancer is the eighth most common cancer in the world. Tobacco, alcohol, and viruses have been regarded as a well- known risk factors of OCC however, 15% of OSCC cases occurred each year without these known risk factors. Recently a myriad of studies has shown that bacterial infection leads to cancer. Accumulated shreds of evidence demonstrate the role of P. gingivalis in OSCC. The virulence factor FimA of P. gingivalis activated the oncogenic pathways of OSCC by upregulating various cytokines. It also led to the inactivation of a tumor suppressor protein p53 and the activation of the Matrix-metalloproteinase protein 9 (MMP9). The present Insilico study uses High-Throughput Virtual Screening, molecular docking, and molecular dynamics techniques to find the potential compounds against the target protein FimA. The goal of this study is to identify the anti-cancer lead compounds retrieved from natural sources that can be used to develop potent drug molecules to treat P.gingivalis-related OSCC. The anticancer natural compounds library was screened to identify the potential lead compounds. Further, these lead compounds were subjected to precise docking, and based on the docking score potential lead compounds were identified. The top docked receptor-ligand complex was subjected to molecular dynamics simulation. A study of this Insilco finding provides potent lead molecules which help in the development of therapeutic drugs against the target protein FimA in OSCC.
Regional Cerebral Oxygen Saturation and Estimated Oxygen Extraction Ratio as Predictive Markers of Major Adverse Events in Pediatric Cardiac Patients
Authors: Kimura Satoshi , Shimizu Kazuyoshi , Izumi Kaoru , Kanazawa Tomoyuki , Mizuno Keiichiro , Iwasaki Tatsuo , Morimatsu Hiroshi
Published: January 2023

Regional cerebral oxygen saturation (ScO2) determined by near-infrared spectroscopy, monitoring both arterial and venous blood oxygenation of the brain, could reflect the balance between oxygen delivery and consumption. The aim of this study was to determine the predictabilities of ScO2 and estimated oxygen extraction ratio (eO2ER) with outcomes in pediatric patients with congenital heart disease (CHD). This study was a two-center, retrospective study of patients at 12 months of age or younger with CHD who underwent cardiac surgery. The primary outcome was a composite of one or more major adverse events (MAEs) after surgery: death from any cause, circulatory collapse that needed cardiopulmonary resuscitation, and requirement for extracorporeal membrane oxygenation. Based on the assumptions of arterial to venous blood ratio, eO2ER was calculated. A total of 647 cases were included in this study. MAEs occurred in 16 patients (2.5%). There were significant differences in the average post-bypass ScO2 [46.61 (40.90, 52.05) vs. 58.52 (51.52, 66.08), p < 0.001] and the average post-bypass eO2ER [0.66 (0.60, 0.78) vs. 0.52 (0.43, 0.61), p < 0.001] between patients with MAEs and patients without MAEs. Area under the receiver operating curve (AUROC) of the average of post-bypass ScO2 was 0.818 (95% confidence interval: 0.747–0.889), AUROC of the average of post-bypass eO2ER was 0.783 (0.697–0.870) and AUROC of post-bypass maximum serum lactate level was 0.635 (0.525–0.746). Both ScO2 and eO2ER, especially after weaning off bypass, are acceptable predictive markers for predicting MAEs after cardiac surgery in infants.
ZBTB5 enhances the resistance of cervical cancer to paclitaxel by regulating BCL6
Authors: He Yue , Zhang Jing-Jing , Xu Jian-Qing , Wang Yun-Fan , Ji Chen , Liu Yang , Han Su-Bin , Wang Ming , Wang Yan , Wu Yu-Mei
Published: January 2023

PURPOSE: To preliminarily clarify the mechanism of paclitaxel (PTX) resistance in cervical squamous cell carcinoma with the involvement of ZBTB5.
RESULTS: 1) Overexpression of ZBTB5 was cultured in PTX, and immunofluorescence showed that overexpression of ZBTB5 enhanced cervical squamous cell carcinoma resistance to PTX by functioning in the cell nucleus. 2) ZBTB5knockdown inhibited cell cloningand proliferation and enhanced apoptosis of cervical squamous carcinoma cells in PTX and reduced resistance to PTX in SiHa cells compared with the non-knockdown group (p < 0.05). 3) A ChIP assay was performed after overexpression of ZBTB5, which suggested that the BCL6 gene is located 395 kb from the TSS region and may be regulated by ZBTB5, which may be the promoter of BCL6. This result was consistent with that of the IPA bioinformatics analysis. 4) Further in-gel enzymatic digestion and shotgun-mass spectrometry protein identification were performed after Co-IP, and 322 differential proteins were identified in the overexpression group. Bioinformatics analysis of different proteins was conducted and 13 proteins were selected for validation: U2AF2, RBM5, ILK, ENAH, JUP, RELA/P65, SQSTM1, YY1, STIM1, Integrin alpha V, EED, SUGT1, and NFKB1. Among them, U2AF2 was successfully detected in the input, suggesting a possible interaction of ZBTB5 with U2AF2.
CONCLUSION: There is a protein–protein interaction between ZBTB5 and U2AF2, and ZBTB5 is involved in PTX resistance in cervical squamous cell carcinoma by regulating BCL6. It was hypothesized that ZBTB5 may form a transcriptional complex with U2AF2 to regulate BCL6 to affect tumor cell proliferation and participate in PTX resistance in cervical squamous cell carcinoma.
Tailoring of Defocused Point Spread Function of Asymmetrically Apodized Four Zone Aperture Optical Imaging System in the presence of Primary Spherical Aberration
Authors: Rani S. Vidya , Anitha P. , Sabitha N. , Sagar D. Karuna
Published: January 2023

In this paper we present the attempts made for the improvement of the resolution of an optical system in the presence of higher orders of defocus and primary spherical aberration function by introducing four level asymmetric filters of Triangular, Connes, Polynomial and Hanning. Four zone aperture shading amplitude in each zone have been tested for better results. Using the above four filters placing Triangular filter in the inner zone, Connes filter in the second zone, Polynomial filter in the third zone and Hanning filter in the outer zone at higher degrees of both defocusing and primary spherical aberration situation provides the optical system to achieve super-resolver state. The highest degree of the amplitude apodization improves the lateral resolution of the central maxima and suppression of side lobes which helps to study the two point resolution.
CircTPST2 inhibits cisplatin sensitivity in head and neck squamous cell carcinoma by sponging miR-770-5p and interacting with Nucleolin
Authors: Wang Tianqing , Xin Chuan , Zhang Shiyu , Shi Yujie , Zhou Xikun , Tian Xin , Yang Dan , Ren Yuan , Hu Yuting , Hua Yufei , Wang Ying , Wang Jiongke , Ji Ning , Chen Qianming , Zeng Xin , Li Jing
Published: January 2023

Background: Head and neck squamous cell cancer (HNSCC) is the most prevalent head and neck malignancy. Chemoresistance is a major challenge in the treatment of advanced HNSCC. Circular RNAs (circRNAs) are essential for the development of cancer and chemoresistance. The role and mechanism of circRNAs in the regulation of HNSCC chemoresistance are much less explored.
Methods: CircRNA microarray analysis was used to detect differentially expressed circRNAs in HNSCC. The expression of circTPST2 and miRNAs in HNSCC cells was assessed by qPCR, and the ring structure of circTPST2 was examined using Sanger sequencing, RNase R, and actinomycin D assays. MiR-770-5p and Nucleolin were found to be downstream target molecules of circTPST2 by Western blotting, biotin-labeled RNA pulldown, RNA immunoprecipitation, mass spectrometry, and rescue experiments. Then, the chemoresistance ability of circTPST2, miR-770-5p and Nucleolin was examined through functional tests such as CCK8 assays and flow cytometry assays. FISH assays were performed to determine the location of circTPST2, miR-770-5p, and Nucleolin. IHC staining assays were applied to detect the expression of circTPST2 and Nucleolin in HNSCC patients.
Results: The expression level of circTPST2 was negatively related to the cisplatin sensitivity of HNSCC cell lines. Notably, the expression of circTPST2 was negatively correlated with the overall survival rate of chemotherapeutic patients with HNSCC. Mechanistically, circTPST2 could reduce the cisplatin sensitivity of HNSCC cells through sponge-like adsorption of miR-770-5p, and it could also interact with and upregulate the downstream protein Nucleolin to regulate cisplatin sensitivity in HNSCC cells. Finally, according to the analysis of the TCGA database, the prognosis of patients with high miR-770-5p expression is better after chemotherapy. In contrast, according to the analysis of our HNSCC cohorts, the prognosis of patients with low Nucleolin protein expression is better after chemotherapy.
Conclusion: Our results identified the chemotherapy resistance-related circRNA circTPST2, indicating that circTPST2 may serve as a promising chemotherapy regimen selection marker in HNSCC.
Hemodynamic Assessment of a Vascular Diseased Model with Therapeutic Nanoparticles
Authors: Rathore Surabhi , Srik D.
Published: January 2023

Nanotechnology has numerous medical uses, including the diagnosis,treatment, and prevention of cardiovascular diseases. Physical abnormalities or heart and blood vessel malfunction are the major causes of heart attacks andstrokes worldwide. Mathematical modeling could help us better understand thesephysiological conditions. Therefore, we present mathematical modeling of a non-Newtonian fluid with therapeutic nanoparticles for a diseased model. In this study,nanoparticles were introduced into a blood vessel using a catheter, and a pressuregradient drove flow within the flow geometry. The perturbation method is used tosolve the resulting mathematical model with permeable flow boundary conditions.A detailed discussion of blood flow analysis is presented, in which temperature andconcentration dispersion, as well as flow field characteristics, are studied. Thesefindings indicate that it is important to understand the effects of therapeuticnanoparticles on physiological properties and pathological conditions.
PACS 5A01 · 65L10 · 65L12 · 65L20 · 65L70
HCV knowledge and attitudes among HIV-negative MSM and MSM living with HIV in China: results from a cross-sectional online survey
Authors: Xu Wenqian , Zhao Peizhen , Li Haiyi , Wang Cheng
Published: January 2023

Background
Men who have sex with men (MSM) are at high risk of hepatitis C virus (HCV) infection, especially for those living with human immunodeficiency virus (HIV). Learning about HCV-related knowledge and attitudes of MSM is essential to inform health promotion interventions development.
Methods
A cross-sectional survey was conducted across seven provinces of China from December 2021 to January 2022. All MSM living with HIV were recruited offline, whereas the recruitment ratios for HIV-negative MSM were half online and half offline. Data on socio-demographic characteristics, sexual behaviors, knowledge and attitudes about HCV were collected through an online survey. Multivariable logistic regressions were used to determine associated factors.
Results
Only 39.3% (33/84) of HIV-negative men and 44.0% (37/84) of men living with HIV had a good level of HCV knowledge. One-third (32.1%, 27/84) of HIV-negative men and 41.7% (35/84) of men living with HIV reported a positive attitude towards HCV. For HIV-negative men, positive attitude was associated with multiple sexual partners (aOR: 5.8, 95%CI:1.9–18.1) and recreational substances use (aOR: 3.1, 95%CI: 1.0-9.4). For men living with HIV, knowledge was associated with disclosing sexual orientation (aOR: 7.0, 1.9–26.0), multiple sexual partners (aOR: 0.2, 0.1-1.0), recreational substances use (aOR: 3.7, 95%CI: 1.1–13.1) and HBV testing history (aOR: 7.3, 95%CI: 1.6–32.7); positive attitude was associated with the use of recreational substances (aOR: 3.1, 95%CI: 1.1-9.0).
Conclusions
The majority of Chinese MSM showed inadequate knowledge and negative attitude about HCV irrespective of HIV infection status. More tailored education campaigns and multicomponent interventions are required.
Hepatoprotective effect of miRNA-544 against LPS-induced septic mice by inhibiting the IKK/NF-κB signal pathway
Authors: Guan Songmei , Ye Zhirong , Miao Huilai , Gong Xiaobao , Zhao Jiasheng , Duan Shigang
Published: January 2023

Aim: To explore the hepatoprotective effects and mechanism of miRNA-544 in septic mice, C57BL/6J mice were intraperitoneally injected with lipopolysaccharide (LPS, 5 mg/kg) and treated with miR-544 inhibitors and mimics.
Methods: The aspartate aminotransferase (AST), alanine aminotransferase (ALT) activities and total bilirubin (TBIL) levels were measured by automatic biochemical analyzer. The expression of proteins (MCP-1, CD16/32 and NF-κB inflammatory signaling pathways) and genes (inflammatory factors TNF-α, IL-6 and IL-1β)were measured by immunohistochemistry, western blot, qRT-PCR and ELISA.
Results:The results indicated that miR-544 significantly reduced the level of ALT, AST and TBIL in serum and liver. Meanwhile, miR-544 attenuated the aggravation of inflammation by inhibiting MCP-1 and CD16/32, and suppressed IKK/NF-κB signal pathway by inhibiting the phosphorylation of IKK, IκB and NF-κB, thereby affecting the expression of inflammatory factors.
Conclusions: miR-544 can attenuate LPS-induced liver injury in mice with sepsis via inhibiting the IKK/NF-κB signal pathway, and it is a potential candidate marker and therapeutic target for sepsis-induced liver injury.
Evaluation of Anti-cancer Effect of Carotenoids Produced by A Halophilic Archaeon, Haloarcula Sp. Strain A15 Isolated from Saline Environment of Iran on Breast Cancer Cells
Authors: Shahbazi Saghar , Zargar Mohsen , Zolfaghari Mohammad Reza , Amoozegar Mohammad Ali
Published: January 2023

The halophilic microorganisms living in Extreme environments contain high concentrations of carotenoids with notable medical abilities. We evaluated the anti-cancer activity of carotenoids extracted from native Iranian halophilic microorganisms with the ability to inhibit breast cancer cell line. To begin the study, 40 halophilic strains were cultured and eight strains capable of producing pigmented colonies were chosen from among those cultured strains. In the next step, from among eight strains using MTT assay, one of them capable of reducing cell viability of the breast cancer MCF-7 cell line was chosen as a selective strain. The principal carotenoid was characterized based on the UV-Visible, FT-IR spectroscopic and LC-MASS analyses. Using Real time PCR technique, the expression of genes specific for apoptosis, in the presence or absence of carotenoid was examined. Among all strains, carotenoid extracted from strain A15 showed the strongest cytotoxic effect on breast cancer cell line (IC50 = 0.0625 mg/mL). 16S rRNA analysis indicated that strain A15 showed similarity with Haloarcula hispanica for about 99.5%. According to the results of the analysis, we can estimate that the principal carotenoid extracted form Haloarcula sp. strain A15 was similar to bacterioruberin. Both late and early apoptosis were increased significantly about 10% and 39%, respectively as a result of up-regulation of CASP3, CASP8, BAX genes expression in MCF-7 cell line. In contrast, the expression of genes MKI67, SOX2 were significantly down-regulated in treated MCF-7 cell line. Halophilic archaeon strain could be a good option to produce high added-value bacterioruberin due to its possible anti-cancer properties.
Underage alcohol consumption in Ghana: A threat to child welfare and development
Authors: Kyei-Gyamfi Sylvester
Published: January 2023

This study examined information regarding prevalence of children ever drinking alcohol, ever been drank, number of times they have taken alcohol, who first introduced them to it, and what they perceived as the effects of alcohol on children. A cross-sectional convergent parallel mixed method was used to study 5024 children aged 8 to 17 in Ghana. This study found that alcohol consumption was less prevalent among the children, but in terms of age higher in older adolescents, and regarding sex prevalent in males than females. More than six in ten have ever been drunk after consuming alcohol, and more than half the children who reported ever taking alcohol were first initiated into consumption by friends. The results show that despite the existence of law, policy, and national institutional mechanisms in place, efforts made to regulate sale and consumption of alcohol among children has been a challenge. Children in certain parts of the country still buy and consume alcohol freely without restrictions. Based on this, national institutions in charge of child protection are enjoined to enhance their monitoring, investigative, arrest and awareness raising operations to dissuade and restrict minors from alcohol sale and consumption.
STURGE-WEBER SYNDROME IN AN EPILEPTIC CHILD: A CASE REPORT
Authors: Wijaya Budi Sarwono Christofer Sathya
Published: January 2023

Sturge Weber Syndrome (SWS) is a congenital neurocutaneous disorder with a facial capillary malformation Port-wine stains (PWS), abnormal blood vessels of the brain (leptomeningeal angioma), or abnormal blood vessels in the eye predisposing to glaucoma. The incidence of Sturge Weber Syndrome (SWS) is a rare entity that accounts about 3 of 1000 births with PWS, 5% of them suffer SWS. We report a case of 5-years-old girl who presented with a three-days history of muscle weakness of right upper and lower limb followed by headache, loss of consciousness, dizziness, with history of hemangioma facial without any symptoms like fever, nausea, vomit, and dysarthria. Patient was a refferal patient from Sarila Husada Hospital Sragen. Head CT-Scan was performed on the admission day on Sarila Husada Hospital Sragen and confirmed by Bethesda Hospital Radiologist revealed a subcortical calcification at frontal lobe and parietal sinistra with mild atrophy at bifrontalis lobes that support SWS.
DIAGNOSTIC CHALLENGE OF LEFT-SIDE APPENDICITIS DUE TO SITUS INVERSUS TOTALIS IN A LIMITED SETTING: A CASE REPORT
Authors: Hartanto Hartanto
Published: January 2023

Background: Acute appendicitis is an acute abdominal case with a high incidence and often requires emergency surgical intervention. Situs inversus totalis is a rare congenital abnormality in which the thoracic and abdominal organs are totally transposed. Left-sided acute appendicitis (LSAA) is common in patients with congenital abnormalities such as situs inversus totalis. Diagnosis of LSAA is even more challenging, especially in peripheral areas which can lead to misdiagnosis and complications such as perforation or abscess. Imaging modalities are usually required to confirm the diagnosis. Case Presentation: A 21 years old male patient came to the emergency department with chief complaint of severe abdominal pain, starting 3 days earlier, localized to the epigastric area and migrating to the left lower quadrant. The patient also demonstrates fever, nausea and vomiting. Physical examination revealed an increasing abdominal wall rigidity and tenderness in the left lower quadrant as well as rebound tenderness. Laboratory tests revealed leucocytosis and increased neutrophils count. The patient underwent 3-position abdominal radiograph after chest X-ray showed dextrocardia. Exploratory laparotomy was done in this patient, showing a perforated appendix and totally transposed abdominal organs. Conclusion: Imaging modalities such as ultrasonography and abdominal CT Scan can be helpful in determining the diagnosis of LSAA and reduce the likelihood of misdiagnosis and complication. The possibility of LSAA and situs inversus should be suspected in a patient presenting with left lower quadrant abdominal pain with proven dextrocardia from chest X-ray. Keyword: Left-sided acute appendicitis, situs inversus totalis, dextrocardia
THE DEVELOPMENT OF AN ALTERNATIVE GROWTH CHART FOR ESTIMATED FETAL WEIGHT IN THE ABSENCE OF ULTRASOUND: APPLICATION IN INDONESIA
Authors: Papilaya Felicia Beta
Published: January 2023

Various development of fetus can be monitored by ultrasound, including estimated fetal weight. Estimated fetal weight is used to estimate the expected (normal) birth weight and it is also one of the critical indicators for assessing fetal risk during pregnancy. Meanwhile, ultrasound is not always available in health care centers in Indonesia. In this journal, Anggraini et al conducted a study to develop growth chart used to predict fetal weight in the absence of ultrasound.

The study consists of several steps. The first step is a comparison study that took place in South Kalimantan, Indonesia, involving 19 pregnant women. This was carried out between the existing and the proposed models. The existing models were developed based on data recorded within one week of delivery and within 14 days of the last ultrasound scan, while the proposed model: EFW (g) = 109.16FH -272 [Eq.1] was developed based on FH measurement recorded between 35 and 41 weeks (before delivery) and actual birth weight. The results show that the proposed model is significantly more capable (less error) than the existing models in predicting fetal weight during pregnancy, even at earlier GAs. It also can be seen that the prediction errors are less pronounced when the pregnancy reaches advanced GAs.

The second step is a study that aims to develop an alternative fetal growth chart for EFW that does not use an ultrasound-based weight prediction model, the proposed clinical model, based only on FH measurement [Eq (1)], was used to estimate the fetal weight at a given GA. A total of 402 women are participating in this study. In this research, the proposed clinical quadratic EFW-GA model: EFW = 137.173GA - 1:035 GA2 - 675:199 [Eq.2] was used to develop the chart. This model was compared with the existing model through several analysis.

Overall, this study shows that the proposed clinical model is more reliable than the existing model in predicting fetal weight. It is even more effective at earlier GAs than the existing models. Therefore, the proposed model could be an alternative model to estimate fetal weight and develop a suitable fetal growth chart. This alternative chart is going to be significantly useful for health care workers to do fetal risk assessment during pregnancy in rural areas with low resources, so that fetal growth abnormalities can be reduced. At this point, this study will also help the government to reduce neonatal mortality.
Case Report Chest Non-contrast ct-scan findings and follow up a patient suspected covid-19 infection
Authors: Dewi Ngesti Chintia , Dermoredjo Sutaryanu Dermoredjo
Published: January 2023

Background Covid-19 is an infection caused by SARS-CoV-2. Chest X-Ray (CXR) examination doesnâ€™t show the radiographiccharacteristic of Covid-19 infection. Thorax CT-Scan is the gold standard imaging for pneumonia Covid-19 infection.Aim The purpose of this report is to describe a case of bronchopneumonia in a male patient aged 48 years old at Bethesda Hospital Yogyakarta during the Covid-19 pandemic.Case Description A 48 years old male patient came to the Bethesda Hospital in Yogyakarta with a complaint of fever 1 week before being hospitalized. The patient also complained of cough, sore throat, rhinorrhea, shortness of breath, malaise, and decreased appetite. The rapid test result shows SARS-CoV2 IgM and IgG (+), PCR swab Covid-19 results (+). Bronchopneumonia was concluded by CXR examination and chest non-contrast CT-Scan showed Covid-19 infection imaging characteristics. Later on, the patient showed clinical and radiological improvement.Conclusion Covid-19 is an infection caused by the SARS-CoV-2. Common symptoms are fever, cough, sore throat, shortness of breath, and malaise. CXR examinations on patients with Covid-19 infection show images of pneumonia, in this case, bronchopneumonia was concluded. CT-scan shows characteristic imaging of Covid-19 infection can support the decision on regular ward admission versus ICU and for follow-up in regular ward admission.
Predisposing Factors of Cardiovascular Events among COVID-19 Patients
Authors: Nugroho Devina Gabriella , Dewi Putri Rachmawati , Nugroho Rima Adjani , Jaeri Santoso
Published: January 2023

Background COVID-19 is an infectious respiratory disease caused by SARS-CoV-2. During hospitalization, there is the possibility of cardiovascular events. The presence of these events might be related to some factors, unfortunately, there is limited evidence for these issues.Objective The aim of the study was to determine the independent predisposing factors associated with the occurrence of the cardiovascular event among COVID-19 patients during hospitalization.Method A retrospective study using medical records of hospitalized COVID-19 patients in K.R.M.T Wongsonegoro Hospital Semarang Indonesia, periods of June to September 2020. One hundred and one patients were included in the study. The subjects were classified into CVE groups and non-CVE, then the demographic characteristics and clinical data were collected. The Chi-Square, the Independent-T as well Mann-Whitney U test were used. The logistic regression then was used to determine the odds ratio of predisposing factors for CVE occurrence.Results There were significant associations for the history of cardiovascular disease, smoking, hypertension, use of angiotensin-converting enzyme inhibitor agents, the level of blood glucose and troponin I, and the systolic blood pressure at the first visit for CVE occurrence. Furthermore, the history of CVD increased the risk 0,007 times to get CVE.test.Conclusion The history of cardiovascular disease, smoking, hypertension, use of angiotensin-converting enzyme inhibitor agents, the level of blood glucose and troponin I, and the systolic blood pressure at first visit are the predisposing factors for the development of CVE among COVID-19 patients and patient who has the history of CVD have a high risk to get CVE during hospitalization.
Quantum order-by-disorder induced phase transition in Rydberg ladders with staggered detuning
Authors: Sarkar Madhumita , Pal Mainak , Sen Arnab , Sengupta Krishnendu
Published: January 2023

^{87} Rb87Rb
atoms are known to have long-lived Rydberg excited states with
controllable excitation amplitude (detuning) and strong repulsive van
der Waals interaction V_{{r} {r'}}Vrr′
between excited atoms at sites {r}r
and {r'}r′.
Here we study such atoms in a two-leg ladder geometry in the presence of
both staggered and uniform detuning with amplitudes
\DeltaΔ
and \lambdaλ
respectively. We show that when V_{{r r'}} \gg(\ll) \Delta, \lambdaVrr′≫(≪)Δ,λ
for |{r}-{r'}|=1(>1)|r−r′|=1(>1),
these ladders host a plateau for a wide range of
\lambda/\Deltaλ/Δ
where the ground states are selected by a quantum order-by-disorder
mechanism from a macroscopically degenerate manifold of Fock states with
fixed Rydberg excitation density 1/41/4.
Our study further unravels the presence of an emergent Ising transition
stabilized via the order-by-disorder mechanism inside the plateau. We
identify the competing terms responsible for the transition and estimate
a critical detuning \lambda_c/\Delta=1/3λc/Δ=1/3
which agrees well with exact-diagonalization based numerical studies. We
also study the fate of this transition for a realistic interaction
potential V_{{r} {r'}} = V_0 /|{r}-{r'}|^6Vrr′=V0/|r−r′|6,
demonstrate that it survives for a wide range of
V_0V0,
and provide analytic estimate of \lambda_cλc
as a function of V_0V0.
This allows for the possibility of a direct verification of this
transition in standard experiments which we discuss.
Las labores de la Iglesia Católica durante las epidemias de cólera en las parroquias del partido de Aguascalientes, 1833 y 1849-1850.
Authors: Paredes Quiroz Lourdes Adriana
Published: January 2023

En este artículo se presentan la labores de la Iglesia Católica durante las epidemias de cólera de 1833 y 1849-1850 en las parroquias que se encontraban en el partido de Aguascalientes. Se describen los auxilios sacramentales, la labor hospitalaria, la creación de camposantos provisionales y las misas rezos y procesiones que organizó el clero para socorrer y aliviar a los feligreses durante las crisis sanitarias.
Libro: Montoya Camacho, Jorge Martín y Giménez Amaya, José Manuel. Encubrimiento y verdad. Algunos rasgos diagnósticos de la sociedad. Pamplona: Eunsa –Astrolabio-, 2021, 346 pp.
Authors: Gutiérrez Delgado Ruth
Published: January 2023

Reseña crítica
Libros: Pollmann, Karla (Ed.-in-Chief) and Otten, Willemien (ed.). The Oxford Guide to the Historical Reception of Augustine. Oxford: Oxford University Press, 2013, 1926 pp.
Authors: Calabrese Claudio César
Published: January 2023

Reseña crítica
Russia – Saudi Arabia: plight and prospects of cooperation
Authors: Fedorchenko A. V.
Published: January 2023

For Russia, the political situation in the Persian Gulf region is of fundamental importance due to the size of its resource potential, its significant role in the global energy sector, geographical proximity, and the influence of the Arabian countries on the Muslim population of our country. The relative political stability and economic weight of the Arabian monarchies serve as the basis of the new – Arabian vector of Russia's Middle East policy. The influence of the monarchies of the Persian Gulf zone, primarily the Kingdom of Saudi Arabia, is growing in the region. The author tried to answer the question: what are the opportunities and prospects for establishing partnership relations between Russia and Saudi Arabia? Besides cooperation in the settlement of regional conflicts and the fight against international terrorism, the creation of a collective security zone in the Persian Gulf, coordination of actions in the oil market, bringing economic relations to a new qualitative level, and the development of humanitarian contacts are the most realistic areas of rapprochement.
Development of Russian export of business services: great potential and ways to fulfill it
Authors: Levashenko A. D. , Magomedova O. S.
Published: January 2023

The development of national exports of business services is indicative of the competitiveness of domestic business services. Today, the global business services market is undergoing a transformation against the background of trends such as the intellectualization of business services and the digitalization of service delivery methods. These trends may allow us to reveal the previously unrealized (until 2022) potential of the Russian export of business services. Despite the sufficient demand for Russian services in segments with such a high knowledge component as engineering, design and architectural services, Russia was mainly an importer of business services. Today, Russian business service providers face the need to reorient exports to new markets, which is associated not only with the usual difficulties of redirecting business, but also with the specifics of the business services themselves. Thus, in the segments of intellectually capacious services, Russian exporters are faced with the need to ensure compliance with the qualification requirements for obtaining admission to participate in the market. In addition, in the new prospective markets, business services are developed in varying degrees, often at a lower level than in the countries of the traditional direction of Russian exports of business services, which is due to the cultural peculiarities of doing business. To provide state support for the export of business services in developing countries, it is necessary to take into account their features that determine the possibilities of marketing promotion of Russian exporters, namely: the importance of the professional reputation of the performer, business networking, private business initiatives. The main task of Russian exporters of business services in new markets is to gain consumer confidence.
NR2F1-AS1: A Functional Long Noncoding RNA in Tumorigenesis
Authors: Hu Jiahui , Peng Fan , Qiu Xinyan , Yang Jingjie , Li Jing , Shen Chuyue , Yuan Chengfu
Published: January 2023

Background:

NR2F1-AS1 is a long non-coding RNA (lnc RNA) that is involved
in different biological processes. It plays an integral role in the pathophysiology
of human diseases, especially tumorigenesis and progression. Therefore, it may be a
promising target for numerous tumor biotherapeutics. The current review study aimed to
show the pathophysiological activities and processes of RNA NR2F1-AS1 in cancer
cells.

Methods:

The contents of the present review were based on information obtained from
PubMed. In the data search, “NR2F1-AS1” was chosen as the first keyword, whereas
“cancer” was chosen as the second keyword. This review selected and summarized
studies published between 2019-2021, concerning the biological functions and mechanisms
of NR2F1-AS1 in the development of tumorigenesis.

Results:

It was found that NR2F1-AS1 regulates a variety of biological activities such as
proliferation, invasion, migration, and apoptosis. It acts as an oncogene because it is abnormally
expressed and promotes the progression of cancer in a variety of malignancies,
including esophageal squamous cell carcinoma, non-small cell lung cancer, breast cancer,
neuroblastoma, endometrial cancer, thyroid cancer, and gastric cancer. However, it
was evident that NR2F1-AS1 inhibits the progression of cancer in cervical squamous cell
carcinoma.

Conclusion:

NR2F1-AS1 is a potential new biomarker and therapeutic target for the treatment
of different cancers.
Exploring Potential Non-steroidal Aromatase Inhibitors for Therapeutic Application against Estrogen-dependent Breast Cancer
Authors: Pandey Khushboo , Bharat Lokhande Kiran , Saha Achintya , Goja Arvind , Swamy Kakumani Venkateswara , Nagar Shuchi
Published: January 2023

Background:

Breast cancer is one of the most commonly diagnosed cancer types among women worldwide. Cytochrome P450 aromatase (CYP19A1) is an enzyme in vertebrates that selectively catalyzes the biosynthesis of estrogens from androgenic precursors. Researchers have increasingly focused on developing non-steroidal aromatase inhibitors (NSAIs) for their potential clinical use, avoiding steroidal side effects.

Objectives:

The objective of the present work is to search for potential lead compounds from the ZINC database through various in silico approaches.

Methods:

In the present study, compounds from the ZINC database were initially screened through receptor independent-based pharmacophore virtual screening. These screened molecules were subjected to several assessments, such as Lipinski rule of 5, SMART filtration, ADME prediction using SwissADME and lead optimization. Molecular docking was further applied to study the interaction of the filtered compounds with the active site of aromatase. Finally, the obtained hit compounds, consequently represented to be ideal lead candidates, were escalated to the MD simulations.

Results:

The results indicated that the lead compounds might be potential anti-aromatase drug candidate.

Conclusion:

The findings provided a valuable approach in developing novel anti-aromatase inhibitors for the treatment of ER+ breast cancer.
Quantitative Harmonic Amplification Analysis in Electric Railway Traction
Power Supply Systems
Authors: Yu Jiahua , Wu Hexiang , He Fengguang , Pan Weiguo , Zeng Liyong , Li Zhaoyang
Published: January 2023

Background:

Harmonic resonance is one of the apprehensive power quality problems in
electric railway traction power supply systems. Harmonic resonances result in big harmonic voltage
distortions or harmonic currents. Different harmonic resonance frequencies existing in a power system
possess varying propagation areas and amplification levels. The frequency scan analysis technique
and the resonance mode analysis technique are the two most commonly used methods. The
frequency scan analysis technique can reveal whether resonance exists and determine the resonance
frequency. Resonance mode analysis technique can further identify the location where a resonance
can be most easily initiatedand observed. However, there are still few studies on the quantitative
analysis of harmonic propagation and resonance amplification in traction power supply systems.

Methods:

The model of the all-parallel autotransformer-fed system in the high-speed railway is built
accurately, then a quantitative analysis method based on harmonic electrical distance is used to
study the harmonic propagation characteristics and propagation severities caused by electric trains,
and analyses in detail the influence of the number of lines, the number of trains, and the location of
the train on the severity of resonance amplification.

Results:

The results of case studies reveal the traction power supply system harmonic propagation
characteristics and amplification severities and system parameter sensitivities in a quantitative way,
validating the effectiveness and superiority of the quantitative analysis method.

Conclusion:

Compared with the resonance mode analysis method and the frequency scan analysis
method, at a harmonic resonance frequency point, the quantitative analysis method can quantitatively
reveal the harmonic propagation area and amplification level at each bus of the traction power
supply system. Meanwhile, it is simple and practical.
Eficiencia financiera de las Cajas Municipales de Ahorro y Crédito (CMAC) del Perú en el periodo 2015-2021
Authors: Rossi Valverde Ricardo Manuel , Rossi Ortiz Ricardo Gabriel
Published: January 2023

Este trabajo utiliza la técnica de tabla de decisiones con variables de entrada Morosidad, ROE, Z2 de Altman, y el grado de relación Morosidad-Z2 y ROE-Z2 para medir la eficiencia del desempeño financiero de las Cajas Municipales de Ahorro y Crédito (CMAC) en una muestra de seis entidades con activos superiores a S/2 billones (2 billones de Soles). Los hallazgos empíricos muestran que CMAC Huancayo, Arequipa, Cusco y Piura logran destacar en su desempeño financiero en 2015-2021, mientras que CMAC Trujillo logra superar el 50% de eficiencia, pero CMAC Sullana es alarmantemente ineficiente. El modelo propuesto proporciona un enfoque integral y pragmático para medir la eficiencia del desempeño financiero de estas microfinancieras, lo cual ha sido una limitante superada por la presente investigación. Entre las conclusiones se destaca que es importante conocer el nivel de eficiencia del desempeño financiero de las CMAC para identificar aquellas con las mejores prácticas en un entorno altamente competitivo.