bluuebunny/crossref_metadata_2025 huggingface dataset:
Personalized program of medical and psychological rehabilitation of dementia patients
Authors: Kaploukh O.M.
Published: December 2023

Dementia affects a person’s adaptation in everyday life, social life and usually affects a professional quality. Caring for patients with dementia causes distress to their family members. In modern psychiatric practice, a multi-vector approach is used within the biopsychosocial model of care for dementia patients. The leading strategy for the treatment of this category of patients includes measures to prevent development of cognitive deficits and, of course, treatment as itself. The main components of treatment are pharmacotherapy, psychotherapy and psychoeducational interventions aimed at people who provide care for patients. A comprehensive program of medical and psychological rehabilitation developed for patients with dementia includes the following components: pharmacotherapy, psychotherapy, psychoeducation (for patients and their relatives), psychological training (training of communicative, cognitive, social skills). As shown by analysis of the effectiveness of proposed program of medical and psychological rehabilitation of patients with dementia, after 1.5 years of catamnestic observation, against the background of using the program, stabilization of the emotional state of patients with dementia and their relatives, a decrease in the level of neuropsychological tension, and an improvement in the cognitive status of patients were noted. The level of socio-psychological adaptation increased, it was possible to preserve social and household skills, and they were able to switch to the use of adaptive coping strategies in patients with dementia and their family members.

Keywords: relatives, rehabilitation, maladaptive behavior, emotional disorders.
Complex psychotherapeutic support of patients with dementia and their family members
Authors: Kaploukh O.M.
Published: December 2023

In Ukraine, the main burden of caring for a patient is borne by his relatives. As the patient’s condition worsens, the burden on the caregiver also increases, the problem of maladjustment of dementia patients’ relatives is urgent, because this disease not only worsens the quality of patient’s life, but also leads to large material and non-material costs due to the need for constant monitoring of persons with severe forms of dementia. In order to achieve the set goal, a comprehensive clinical psychopathological and psychodiagnostic examination of 93 dementia patients (45 women and 48 men) and 97 of their relatives who provided care for the patients (56 women and 41 men) was conducted by us. For the majority of examined women and men, relative with dementia became a psychotraumatic situation. Based on the received data, it was developed a program of medical and psychological support for patients with dementia and their family members, which is aimed at their reorientation from fixation on the problems as a result of the disease, to focusing on adaptation and resocialization of the patient, restoration of life satisfaction, optimization of interpersonal interaction. The program included the complex use of psychotherapy, psychoeducation and occupational therapy methods. As the results of the dynamic observation showed, against the background of the application of the proposed system of medical and psychological support, stable positive dynamics of the psychological state of dementia patients and their family members were noted, with a statistically significant reduction in anxiety-depressive states, a decrease in family conflict, and the harmonization of marital relations. The positive dynamics of family functioning was noted with the prevalence of an adequate attitude of relatives to the disease, understanding complexity of the disease, optimization of compliance, a conscious willingness to follow the doctor’s recommendations with the formation of realistic expectations for treatment.

Keywords: cognitive disorders, mental health support, resocialization, complex therapy.
Invariants of Immersions on n-Dimensional Affine Manifold
Authors: Khadjiev Djavvat , Beshimov Gayrat , Ören İdris
Published: December 2023

Main results: The system of Christoffel symbols of the connection of an immersion ξ:J→R^n of an n-dimensional manifold J in the n-dimensional linear space R^n is a system of generators of the differential field of all Aff(n)-invariant differential rational functions of ξ, where Aff(n) is the group of all affine transformations of R^n. A similar result have obtained for the subgroup SAff(n) of ⁡Aff(n) generated by all unimodular linear transformations and parallel translations of R^n. Rigidity and uniqueness theorems for immersions ξ:J→R^n in geometries of groups Aff(n) and SAff(n) were obtained. These theorems are given in terms of the affine connection and the volume form of immersions.
New Steady State Current Error Limiters for PMSM Drives
Authors: Ravı Hemantha Kumar , N C Lenın
Published: December 2023

In permanent magnet synchronous motor drives, d-q current errors are examined using hysteresis controllers. The inverter is switched based on the hysteresis controller responses, to limit current errors, thereby reducing current ripple. But, due to the faster current dynamic characteristics, switching the current errors within the hysteresis band becomes difficult. This results in d-q current ripples and harmonics. In this paper, two current error-limiting schemes are proposed. In the first scheme, current errors are switched within the band using additional control parameters (dynamic response of q-axis current), to select the control space vector from a switching table. Whereas in the second scheme, a duty ratio regulator is designed to achieve minimum q-axis current error. The proposed works are simulated in MATLAB/Simulink and verified through experimentation. Since the current ripple and harmonics are also reduced, the thermal impact of these performance parameters on the power inverter is also studied.
Evaluation of Building Energy Performance Based on Settlement Scale Design Parameters Using BIM Tools
Authors: Aydın Mehmet Akif , Koçlar Oral Gül
Published: December 2023

After the settlement textures were designed and constructed, they continue to exist without any change for years, and they have considerable effects on building energy consumption and the natural environment. With the changes in our lives following the COVID-19 global pandemic, employers have adopted working from home in many sectors, and energy expenditures in residences are increasing even more. The decrease of energy usage is a top objective in the design of the settlements from an economic and environmental standpoint. Also, while known energy modeling methods require extra expertise, labor and time in the integration of energy efficient design strategies into design processes, BIM systems have a significant potential in the evaluation of building energy efficiency. In this study, for the comprehensive evaluation of design parameters, different settlement texture alternatives, have been developed and building design parameters determined. These settlement textures were interpreted based on their annual energy consumption. By comparing the results, optimum values were sought for the settlement texture design parameters which are H/W, orientation, building height, and form factor. In addition, energy modelling and simulations were carried out with BIM software, and the use, advantages and capabilities of BIM systems were tested in the energy efficient design for reducing energy consumption. As a result, energy consumption in buildings get changes greatly in regard to combination of settlement scale design parameters. Alternative with form factor 3.00,10 storey, directed to east-west, and H/W 0.5 showed best performance and provided 7% to %17 energy reduction according to different parameter combinations.
BUCCAL CELL MICRONUCLEI ASSAY: A POTENTIAL BIOMARKER FOR ORAL CARCINOGENESIS AND MALIGNANT RISK
Authors: R Shetty J Varsha
Published: December 2023

Biomarkers are instruments of individual tumor prevention and help to detect high risk patients. Detection and quantication of certain biomarkers
in non-invasive and painless procedures such as oral exfoliative cytology can help detect high risk patients and also help improve patient
compliance to a larger extent. A recent surge of interest has been generated in one such promising marker 'Micronucleus'. Micronuclei are
extranuclear cytoplasmic bodies induced in cells by numerous genotoxic agents that damage chromosomes. Genomic damage is considered to be
the most important cause of developmental diseases. It is also well known that genetic damage is caused by genotoxins, chemicals, radiation,
micronutrient deciency and genetic factors such as inherited defects in DNAmetabolism and repair. The micronucleus test is used as an indicator
of genotoxic exposition, as it is associated with chromosomal aberrations. The 'Buccal Cell Micronucleus Assay' provides information on the
cytogenic damage in the tissues that are targets of human carcinogens and from which carcinomas can develop.
REPLACED COMMON HEPATIC ARTERY PASSING ANTERIOR TO PANCREAS: A RAREAND CHALLENGING ANATOMICAL VARIANT DURING PANCREATICODUODENECTOMY
Authors: Basa vaiahchowdary Damacharla , Kolandasamy C. , Sugumar C. , Babu O.L Naganath
Published: December 2023

Background: Safe Whipple's procedure needs proper knowledge about Anatomy to avoid injuries . Normal vascular anatomy(celiac and hepatic)
can be found in only 50–70% of individuals. Good knowledge about aberrant vascular anatomy is required to avoid unnecessary complications.
Case presentation: An elderly man presented with history of obstructive jaundice due to Periampullary carcinoma with abnormal CHA and left
hepatic artery morphology was discovered after MD CT (Pancreatic protocol).After ERCP Stenting for cholangitis we have proceeded for
Whipple's procedure Despite the anomalous origin and anterior course of replaced Comm Conclusion: on hepatic artery, Classical Whipple's with
preservation of replaced Common hepatic artery and regional lymphadenectomy with no major intra and post-operative problems was conducted
by superior mesenteric artery rst approach. Prior to major hepato- pancreaticobiliary surgery, a thorough examination of a contrast enhanced
computerized tomography scan is required to understand vascular anatomy, recognize anomalous vessels, and understand their signicance.
Nevertheless, if the abnormal vessel anatomy like replaced Common hepatic artery are identied during surgery, a careful dissection of the
anomalous vessel is essential to identify all vascular relationships and avoid irreversible injury.
EFFECT OF INTERFERENTIAL THERAPY AND MYOFASCIAL RELEASE IN FIBROMYALGIA-A CASE STUDY
Authors: Sethi Priyanka , Dewanji Sen Elina , Chorsiya Varsha
Published: December 2023

A 58-year-old woman with poor well-being and living with symptoms of severe chronic pain, mood swings, insomnia, depression, poor social life,
poor autonomic function, negative thoughts, water retention has reported for the restoration of normal life. The patient was provisionally diagnosed
with persistent depressive disorder. Patient was on pharmacological intervention from last twenty-ve years and on regular medications including
serotonin reuptake inhibitors (SSRI's) and Triazolam for treating Insomnia. The patient was admitted in a psychiatric unit for one month of
treatment and underwent cognitive behavior therapy along with pharmacological interventions. Due to lack of effectiveness of these medications,
the patient became more aggressive and complains of low self-esteem and severe insomnia. She nally approached a physical therapy centre with
the complains of severe fatigue and pain at different body sites. She was examined by the physical therapist, complete medical history, general
assessment, physical examination was conducted. Patient was initially diagnosed with Generalized body aches but after few days of treatment and
regular visits and in patient discussions, she was diagnosed with bromyalgia. The Visual Analogue Scale (VAS) was recorded to be 9 at the scale of
10, Pain pressure threshold (PPT) assessed with Digital algometer was 6.76 KPA and having trigger points at almost 13 different bodily sites. The
Erythrocyte Segmentation rate was also reported higher than the normal limits. The patient was initially treated with Interferential therapy to
release the inammation later followed by Myofascial Release Techniques (MRT) and generalized exercises were advised to be done at home by
the patient herself. This treatment was given for one month regularly, later followed by three days per week for another two months respectively.
The patient has responded well to this treatment and there were marked improvement in the symptoms. The signicant change was noticed in
chronic pain, mood swings, social activities, and inammation and indirect improvement was observed in insomnia, and negative thoughts. The
patient was advised to follow the exercise regimen at home for another three months and should visit the clinic for regular follow ups fortnightly.
This six-month patient centric approach helped in restoration of the well-being of a patient and presented as the nal cure of bromyalgia. The
patient was also guided to report back to the clinic if notice any prevailing symptoms. A further study has been proposed and planned to treat the
patients with similar symptoms of chronic and widespread pain indicative of bromyalgia. The same protocol can be followed and to check the
efcacy and to mask the effect of this therapeutic approach among similar patients. The efcacy in protocol can help to evaluate the condition and
would help designing the clinical management of Fibromyalgia syndrome (FMS)
THE ENIGMA OF THE BEZOLD-JARISCH REFLEX: A CASE REPORT IN THE CONTEXT OF ACUTE MYOCARDIAL INFARCTION
Authors: Puri Piyush , Kachhadia Meet , Bhagat Ridhi , H. Suhagiya Gaurang , Prachi Fnu
Published: December 2023

This article discusses the Bezold-Jarisch Reex (BJR), a cardiopulmonary reex characterized by bradycardia, hypotension, and peripheral
vasodilation. It presents a case study of a 72-year-old woman who experienced the BJR after thrombolysis for acute inferior myocardial infarction
(MI) involving the right coronary artery (RCA). The article explores the pathophysiology, diagnosis, and management of the BJR. The reex is
considered a reliabl indicator of successful thrombolysis and may have a benecial effect on coronary patency. However, the BJR can also lead to
dangerous complications such as hemodynamic instability and compromise of cardiac output. Management involves reversing vagal effects,
maintaining uid volume, and cautious use of vasopressors while avoiding excessive vasoconstriction and increased myocardial oxygen demand.
“ALVARADO SCORING SYSTEM IN PRE OPERATIVE DIAGNOSIS OF ACUTE APPENDICITIS - A CLINICOPATHOLOGICAL CORRELATION – A PROSPECTIVE STUDY OF 100 CONSECUTIVE PATIENTS”
Authors: Patel Sanket , Gaikwad Kiran , Belekar Dnyanesh
Published: December 2023

Background: Appendicitis is the most common acute surgical condition of the abdomen. The clinical diagnosis of acute appendicitis is unreliable
in spite of numerous attempts to improve diagnostic accuracy. The rate of negative exploration of young females is still in the range of 25−30%. Our
study aims to assess the usefulness of the Alvarado score and to evaluate its feasibility and value as an aid in surgical decision-making in cases of
possible appendicitis in reducing the number of negative laparotomies. 100 consecutive Methods: patients presenting with acute pain in the
abdomen and admitted to the surgery department were included in the study after receiving consent to participate. They were analyzed on the basis
of age, sex, clinical examination ndings, blood investigations, radiological ndings, Alvarado score, Operative ndings, and postoperative
complications. Our study shows a positive predictive value of 86.9% comparable wit Results: h literature reports of 97% [13]. We had a negative
appendicectomy rate of 6%. Similar results were reported in literature; 7% [13], 21% [14], 15.6% [15]. Alvarado scoring is a good Conclusion:
diagnostic scoring system used in day-to-day practice by all clinicians. It is a scoring system used for the evaluation of acute appendicitis with a
score of less than 4. Those whose scoring system is between 5 to 7, are kept under observation and they are surveyed and re-examined for every 2
hours for the score to be increasing or decrease.
FUNGAL RHINOSINUSITIS: A CLINICOPATHOLOGICAL STUDY
Authors: H Chandan Rajesh , L Nayana , Reddy Purushotham
Published: December 2023

Background: The diverse manifestations seen in both clinical and radiological aspects accompany fungal infection of mucous membranes in the
nose and sinuses. This condition can have severe consequences, potentially leading to signicant illness and even death. Consequently, it is crucial
to maintain a high level of suspicion regarding fungal causes when dealing with patients experiencing rhinosinusitis. To establish its Aim:
prevalence and contribute to the development of effective treatment guidelines. Additionally, to identify the various types of fungi responsible for
causing rhinosinusitis. Our study with cross-sectional design was conducted on 450 pa Materials and Methods: tients of rhinosinusitis.
Comprehensive clinical histories were extracted from medical records, while culture reports were collected whenever possible. To examine the
specimens in detail, histopathological examinations were performed using staining techniques such as Hematoxylin and Eosin, as well as special
stains like PAS and GMS stains. The collected data was subsequently analyzed to derive ndings and conclusions. A total of 247 cases of Results:
Fungal Rhinosinusitis (FRS) were diagnosed, out of which 79 cases were diagnosed in Chronic Rhinosinusitis (CRS) patients and 168 cases in
Acute Rhinosinusitis (ARS), those with COVID-19. Most common age group affected was 41-50 years. Among CRS patients, 46 (58.2%) patients
were diabetics, 76 (96.2%) had nasal obstruction, 75 (94.9%) had nasal discharge, 70 (88.6%) had headache, 66 (83.5%) had sneezing, 21 (26.6%)
had facial pain and 17 (21.5%) had eye symptoms. Among 168 patients with ARS, 131 (78%) patients were diabetics, all the 168 (100%) patients
had nasal obstruction, nasal discharge, head ache and sneezing, 133 (79.2%) patients had facial pain and 67 (39.9%) patients had eye symptoms.
Irrespective of the type of FRS, Maxillary sinus was the most common sinus involved, and Mucormycosis was the most common fungus isolated
on HPE. With the growing incidence of FRS in India, it becomes imperative to Conclusion: raise awareness among pathologists, microbiologists,
and treating physicians regarding accurate diagnosis of FRS. The identication of fungi in these cases holds signicant importance, not only for
diagnosing chronic sinusitis, but also for guiding appropriate treatment strategies, particularly when dealing with infections caused by uncommon
pathogens.
SEROPOSITIVITY OF HEPATITIS B IN PATIENT'S ATTENDING INTEGRAL INSTITUTE OF MEDICAL SCIENCES & RESEARCH - A RETROSPECTIVE STUDY
Authors: Charan Ram , Srivastava Swati , Jahan Sarver , S Bhandari Birendra , Ojha Bhupendra
Published: December 2023

Background: Hepatitis is a general term meaning inammation of the liver that can cause a range of health problem can be fatal when liver is
inamed or damaged, its function can be affected. The main causes of hepatitis are toxins, blood transfusion, having sex with multiple infected
partners, can be severe due to heavy alcohol consumption. However, hepatitis is often cause by a variety of different viruses such as hepatitis A, B,
C, D and E. While the all types of viruses can cause liver disease and they can differ in important ways including modes of transmission, severity of
the illness, geographical distribution and prevention methods. Materials & Methods: It was a two years retrospective study. The data was
collected from the records maintained at Department of Microbiology, IIMS&R, Lucknow. Results: out of 13476 serum samples were screened for
hepatitis B virus 455 (3.37%) were positive with 286 (2.12%) males and 169 (1.25%) females. prevalence of HBsAg was signicantly higher in
males 4.83% than females 2.23% and highest among age group 45-59 years (25.49%), and lowest among age group >75 years (2.19%).
Conclusion:The number of higher seroprevalence in male be due to outdoor works, involvement in multiple sexual partners, drug use. Differences
in the prevalence of HBVinfection in a given population can occur because of use of different ICAbased rapid assays.
GALL BLADDER AGENESIS:AN INCIDENTAL FINDING
Authors: Dubey Alok , Kolandasamy Chinnusamy , Lakshmana moorthy Naganath Babu Obla
Published: December 2023

Gallbladder agenesis (GA) is a rare congenital anomaly of the biliary system often associated with other congenital abnormalities. Patients become
symptomatic in 23% of cases. It is often misinterpreted as other diseases or discovered incidentally. MRCP is the investigation of choice and
surgery has limited role in management. We report a case of congenital GA which was discovered in a patient of penetrating injury to abdomen.
'IN VITRO LINEZOLID SUSCEPTIBILITY PROFILE IN DR-TB ISOLATES IN CENTRAL INDIA UTILIZING MGIT 960 LIQUID CULTURE SYSTEM'
Authors: Niti Verma Abhilasha , K. Srivastava Ashutosh , Singh Rajput Dharmendra , Mutha Anita
Published: December 2023

Background & objectives: Linezolid is increasingly being used in drug resistant tuberculosis treatment. This study was aimed to assess Linezolid
susceptibility prole in DR-TB isolates at Intermediate Reference laboratory, Department of Microbiology, Mahatma Gandhi Memorial Medical
College, Indore, Madhya Pradesh. Methods: This was a prospective study conducted from August 2021 to July2022. 110 DR-TB isolates once lab
conrmed by Line probe assay were selected and Linezolid Susceptibility testing was done on liquid culture using MGIT 960 Liquid Culture
System with dened concentration as per protocol adopted from NTEP. Results: Linezolid susceptibility testing was done on 110 DR-TB
isolates.3 (2.73%) of the 110 isolates tested for Linezolid susceptibility by MGIT-based susceptibility testing (August 2021 to July 2022) were
Linezolid resistant. Conclusion: Linezolid resistance poses an important risk to the success of customized treatment regimens. Linezolid
susceptibility prole is important to support clinical decision-making for improved patient outcomes.
BACTERIOLOGICALAND CLINICAL PROFILES OF PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIAAT A TERTIARY CARE CENTRE IN NORTHERN INDIA
Authors: Singh Pushpender , Kumar Amit , U Reshma
Published: December 2023

Introduction: Pneumonia, characterized by acute lung inammation, can result from infectious or non-infectious factors and ranks as a leading
infectious disease-related cause of death in the United States. Globally, lower respiratory tract infections, including community-acquired
pneumonia (CAP), contribute signicantly to disease burden, with India shouldering a substantial portion. Bacterial proles of CAP exhibit
geographical and temporal variation, inuenced by antibiotic use, environmental factors, and disease awareness. This study aims to analyze the
clinical and bacteriological characteristics of CAP in a North Indian tertiary care center. Objective: To analyze the bacteriological and clinical
characteristics of individuals diagnosed with community-acquired pneumonia at a tertiary care center in Northern India. Methods: A crosssectional study included 100 diverse CAP patients, with data collected on demographics, clinical symptoms, comorbidities, and antibiotic
sensitivity. Laboratory assessments comprised blood cultures, sputum samples, and radiological evaluations. Statistical analysis determined
associations between clinical features and bacteriological ndings, with ethical guidelines followed. Results: Most patients were male (55%) with
hypertension (30%) as a common comorbidity. Streptococcus pneumoniae was the predominant pathogen (35%), and typical symptoms included
cough (95%) and fever (90%). Antibiotic sensitivity varied, with Vancomycin exhibiting the highest sensitivity at 90%. Conclusion: This study
reveals key insights into CAP in Northern India, emphasizing the predominance of Streptococcus pneumoniae, common clinical symptoms, and
varying antibiotic sensitivities. Understanding local CAP proles is crucial for effective management and guideline adherence during
exacerbations.
EVALUATION OF RISK FACTORS AND RADIOLOGICAL DISCOVERIES RELATED TO MDR-TB WITHIN THE PATIENT POPULATION AT A TERTIARY HEALTHCARE FACILITY
Authors: Singh Pushpender , Kumar Amit , kumar Rajan , Mehta Sahil
Published: December 2023

Introduction: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis, primarily affecting the lungs and transmitted
through close contact with infected individuals. Latent TB can become active due to factors such as HIV infection, age, diabetes, and close contact
with active TB cases. TB remains a signicant global health challenge, with millions of new cases reported annually, causing substantial morbidity
and mortality. Multidrug-resistant tuberculosis (MDR-TB) poses an even greater threat due to resistance to standard treatments. Radiological
ndings are crucial for diagnosing and monitoring MDR-TB. Objective: This study aimed to assess risk factors associated with MDR-TB and
investigate radiological ndings in MDR-TB patients at a tertiary healthcare facility. Materials and Methods: A cross-sectional study was
conducted at a tertiary healthcare facility in Northern India, involving 150 MDR-TB patients. Demographic data, risk factors, and radiological
ndings were collected and analysed. Logistic regression was used to identify signicant risk factors. Results: The study found an equal
distribution of MDR-TB cases among male and female patients, with a mean age of 42.5 years. Risk factors included previous TB treatment (40%),
contact with active TB cases (20%), diabetes mellitus (16.67%), immunocompromised conditions (13.33%), and age ≥ 60 years (10%).
Radiological ndings revealed lung cavities (33.33%), nodules (43.33%), extensive lung lesions (26.67%), and mixed patterns (20%). Notably,
HIV-positive individuals had a 2.25-fold higher risk of MDR-TB compared to HIV-negative individuals (p-value = 0.015). Conclusion:This study
underscores the importance of considering risk factors and radiological ndings in MDR-TB management. Addressing comorbid conditions, close
contact tracing, and HIV screening are crucial in tackling MDR-TB. These ndings contribute to our understanding of MDR-TB and highlight the
need for comprehensive strategies in high-burden regions
DETERMINING THE SEVERITY OF ATOPIC DERMATITIS IN CHILDREN PRESENTING IN GENERAL PRACTICE: AN EASY AND FAST METHOD
Authors: Jaiswal Ruchi , Nicholson Parmar Glory , Kumar Brajendra
Published: December 2023

Assessment of the severity of atopic dermatitis (AD) is necessary to evaluate the disease process. This study evaluates and validates the TIS in
children with AD presenting in general practice. We determined the severity of AD using the TIS and the objective SCORAD. The interobserver
agreement for the TIS and SCORAD was calculated, as was the correlation between TIS and SCORAD. The mean time to assess the TIS was less
than one minute. A moderate-to-good agreement between the observers was found for the TIS (κ 0.604 or 0.464), or SCORAD (κ 0.695 or
0.700). There was an excellent correlation between TIS and SCORAD (rs 0.755–0.839). In conclusion, the TIS is an easy and fast method to
score AD. Because of the moderate to good interobserver agreement and the high correlation with the SCORAD, we recommend the TIS to
determine the severity of AD in general practic
COMPARISON OF X-RAY KUB AND UNENHANCED HELICAL CT FOR THE DETECTION OF RESIDUAL CALCULI IN POSTOPERATIVE URSL PATIENTS: IMPLICATIONS OF POSTOPERATIVE FOLLOW-UP
Authors: Chengalvarayan G. , Ashiq G Jeffrey
Published: December 2023

Introduction and Objective: To assess the sensitivity and specicity of KUB radiography and Unenhanced Helical CT for identifying ureteric
calculi in post-operative URSL patients. We assessed the lms of X Methods: ray KUB and Helical CT taken on the 2nd postoperative week of 130
patients. Location, size, number of calculi and HU were recorded and compared. 82 Results: patients were males and 48 patients were females in
our study. For 118 patients, stones were visible in the preop X-ray KUB and for 12 patients stones were not visible in preop X-ray. All stones
visualized in preop X-ray KUB were also detected in CT. Mid ureteral stones are the ones which was not visible in the X-ray KUB, but was
visualized in CT when compared to the proximal and distal ureteric stones. The sensitivity and specicity of Postop X-ray KUB in detecting
Residual Ureteric calculus is 24% and 100%. The Sensitivity and Specicity of Postop CT in detecting Residual Ureteric calculus is 100% and
82%. The sensitivity and specicity of Post URSL CT scan is better than Conclusions: that of Postop X-ray KUBs. A high index of suspicion is
required in the post op setting to label the patient as Stone free and Non contrast CT should not be with-held if deemed necessary.
IMAGING DIAGNOSIS OF CARBON MONOXIDE POISONING
Authors: Bhurrji Prishaa , Thakrar Ritvik , Sanzgiri Sanjana , Harshe Gayatri , Verma Mitusha , Patkar Deepak
Published: December 2023

Carbon monoxide, a colourless, odourless and tasteless gas causes toxicity when excessive amounts of the gas is inhaled. Individuals usually
become unconscious before they realise, they are getting poisoned. Severe tissue hypoxia can occur if this condition is not treated immediately,
therefore, appropriate diagnosis using imaging and management is crucial.
THE MIRNAS: A POTENTIAL BIOMARKER FOR CERVICAL CANCER
Authors: Singh Nisha , Agrawal Suchi , Agrawal Preeti , Gupta Surbhi , Rawat Neha , Upadhaya Kirti , Singh Negi Ankit , Nigam Nitu
Published: December 2023

MicroRNAs (miRNAs) are small, non-coding RNA molecules consisting of 21-25 nucleotides. They play a crucial role in post-transcriptional gene
regulation, inuencing several signaling pathways, including Notch, Wnt/beta-catenin, PI3K-Akt, and the epithelial-mesenchymal transition
(EMT) pathway. The EMT pathway is linked to various malignant behaviors such as proliferation, invasion, and metastasis. The miRNAs are
known to play a crucial role in controlling the EMT phenotype. Understanding the relationship between EMT-associated miRNAs and cancer
chemoresistance is essential for both basic and clinical research, particularly in cervical cancer (CC) where miRNAs have been associated with
chemoresistance. Utilizing miRNA-based treatments could be a potential method to overcome chemoresistance. One notable advantage of
miRNAs is, their stability in body uids like blood, urine, and tissue, making them effective biomarkers for human cancers. However, the
translation of miRNA-based biomarkers from the laboratory to practical applications remains a challenge, despite their potential as biomarkers for
pre-cancer diagnosis in humans. This review include the biogenesis of miRNAs development of cervical cancer, their pathways, various types of
miRNAs involved in cancer are also elaborated in later part of review.
ASSOCIATION OF ALOPECIA AREATA WITH AUTOIMMUNE DISEASES – A CLINICAL STUDY IN A TERTIARY CARE CENTRE
Authors: Thiriveedhi Praveena , Srividya Srividya , Latha Midde Madhavi
Published: December 2023

Alopecia areata (AA) is a common cause of non-cicatricial alopecia that occurs as a patchy, conuent, or diffuse pattern. Autoimmune etiology is
proposed due to its association with other autoimmune diseases. The aim of the current study is to determine the association of alopecia areata with
autoimmunity.The current study includes 80 patients of Alopecia areata. The patchy type was most common and thyroid disorders were the most
common association followed by diabetes mellitus and vitiligo. Among the thyroid disorders, hypothyroidism was the most frequent association.
As the association is statistically signicant, it is important to screen alopecia areata patients for thyroid disorders.
MICROBIOLOGICAL PROFILE AND ANTIBIOGRAM OF ISOLATES FROM RHINOSINUSITIS CASES ATTENDING TERTIARY CARE HOSPITAL IN SOUTH INDIA
Authors: M.S.S Pradeep. , Sri. K Shanti , T Deepthi
Published: December 2023

Introduction: Rhinosinusitis (RS) is a group of disorders characterized by inammation of the mucosa of nose and paranasal sinuses which is a
signicant health issue worldwide for which a lot of non recommended medications are being prescribed and clinicians should be aware of current
trends of microbiological prole and their antibiogram before initiating treatment to stop the emergence of superbugs in the community.
Objective: To isolate and identify the microbial pathogens from cases of rhinosinusitis and perform antibiotic susceptibility testing on the isolates
using standard protocol. Results: Out of 125 samples collected from clinically diagnosed or clinically suspected cases of rhinosinusitis, 60 (48%)
were from cases of Acute Rhinosinusitis (ARS) and 65 (52%) were from cases of Chronic Rhinosinusitis (CRS) out of which 110 (88%) were
culture positive in which 52 (47.3%) were from ARS and 58 (52.7%) were from CRS. In cases of ARS, Staphylococcus aureus (MSSA) was the
predominant isolate (19.3%) followed by Moraxella cattarhalis (17.3%) and Streptococcus pyogenes (15.3%) and from cases of CRS
Staphylococcus aureus (MRSA) was predominant isolate (15.5%) followed by Klebsiella pneumoniae (13.8%) and Coagulase Negative
Staphylococcus (12%). Out of the Gram positive isolates from ARS majority of them showed highest susceptibility to vancomycin, linezolid,
ciprooxacin, ceftriaxone (100%) and Gram Negative isolates showed highest susceptibility to amoxyclav, ceftriaxone, ciprooxacin, polymyxin
B, tigecycline (100%). Gram positive isolates from cases of CRS showed highest susceptibility to vancomycin, linezolid, clindamycin,
tetracycline, ceftriaxone (100%) and Gram negative isolates showed highest susceptibility to polymyxin B, tigecycline, amikacin, meropenem,
imipenem, piperacillin tazobactam and cefoperazone sulbactam (100%). Conclusion: This study gives an insight about various etiological agents
and their antibiogram in cases of ARS and CRS inorder to create awareness in the clinicians and help them to follow evidence based clinical
practice guidelines which will help the patients in speedy recovery and also help in reduction of Antimicrobial resistance (AMR).
CLINICOETIOLOGICALAND BIOCHEMICAL PROFILE OF NEONATAL CONVULSIONS
Authors: Patwardhan Ajay , Kumar Brajendra
Published: December 2023

Neonatal seizures may present in 1-2% of term to almost 20% in preterm infants. Hypoxic ischemic encephalopathy, sepsis and bacterial
meningitis are common causes. Biochemical abnormality and intra cranial bleed is also quiet common in this age. Aim of our study was to observe
clinical presentation, to nd common etiological factors and analysis of associated biochemical abnormality in newborn presented with neonatal
convulsions in our hospital. Prospective hospital based observational study. From January 2014 to December 2014, total 168 newborns admitted
with convulsions or developed convulsions during hospitalization, 154 were included in the study. After taking complete history and appropriate
physical examination, blood sample was collected before instituting specic therapy. Investigations advised to all were complete blood count,
sepsis screen, blood sugar, serum electrolytes. CSF study, serum bilirubin, USG cranium, CT scan or MRI was also ordered when indicated.
Cumulative frequency of neonatal convulsion in our study was 5.52%. Perinatal asphyxia was most common etiological factor in term or post term
babies and presentation of seizures was early, intra cranial bleed and metabolic abnormality was common cause of convulsions in premature babies
and presentation of seizure was somewhat late. Subtle seizure was most common type of ts followed by clonic type of seizures. Hypocalcemia was
most common biochemical derangement. Hypoxic ischemic encephalopathy was most common etiology of neonatal convulsions, presented with
convulsions within 72 hours of life and subtle seizure and focal clonic or multifocal clonic was most common seizure type.
Collaborative Sharing Intelijen Ancaman Pada Komunitas Csirt Dalam Memperkuat Keamanan Siber Nasional
Authors: Sigiro Farlin Hottua , Runturambi Arthur Josias Simon , Widiawan Bondan
Published: December 2023

Sistem keamanan siber dalam beberapa tahun terakhir berkembang dan terlembaga, hal ini dikarenakan faktor keamanan siber telah menjadi perhatian penting, terutama pemerintah Indonesia. Pemerintah melalui BSSN telah banyak me-launching CSIRT (Computer Security Incident Response Team). CSIRT merupakan Tim Tanggap Insiden yang memberikan layanan untuk melindungi sistem atas insiden siber. Meskipun demikian, fenomena insiden siber yang menimpa sektor pemerintah tetap masif. Di sisi lain, lanskap keamanan siber dalam tiga tahun terakhir menunjukkan bahwa kemampuan ancaman siber meningkat signifikan, dan jumlahnya semakin banyak, puluhan varian malware muncul setiap bulan. Oleh karena itu, lembaga dan organisasi tidak cukup dengan melakukan pemantauan dan respon insiden yang bersifat reaktif, namun harus mengubah strategi dengan menggabungkan langkah-langkah keamanan preventif dengan intelijen ancaman. Pengembangan kemampuan Intelijen Ancaman Siber (CTI) dinilai sangat efektif untuk meningkatkan postur keamanan siber. Saat ini program CTI ada di BSSN. Namun, distribusi informasi masih bersifat satu arah, dari BSSN ke CSIRT lembaga. Penelitian ini menggunakan pendekatan kualitatif dengan teknik menggunakan studi kajian pustaka dari penelitian sebelumnya observasi. Hasil penelitian ini menunjukkan terdapat trend ancaman siber semakin tinggi dalam dua tahun terakhir. Beberapa insiden mengalami ekskalasi ancaman pada informasi vital nasional. Oleh karena itu intelijen ancaman siber sektor pemerintah harus dikerjakan bersama-sama oleh komunitas CSIRT. Di akhir, penelitian ini mengusulkan model collaborative sharing CTI yang melibatkan seluruh CSIRT pada masing-masing sektor untuk meningkatkan keamanan nasional.
Os efeitos dos Distúrbios Respiratórios do sono na população brasileira: uma exploração multidisciplinar da doença apneia obstrutiva do sono
Authors: Sampaio de Araújo Bianca Mayara , Zanuto Thiago , Martins Marystela Batista , Rêgo Sophia Shinohara Soares do , Rodrigues Yanne de Araujo , Abdel Aziz Ludmyla Alcântara , Jesus Laura Souza de , Jesus Lorena Souza de , Basso Orisson De Steffani , Azevedo Leidiane dutra Ferreira de , Zanoni Rodrigo Daniel
Published: December 2023

A síndrome da apneia-hipopneia obstrutiva do sono (SAHOS) é uma doença que acomete principalmente pessoas idosas e obesas, porém pode estar presente em crianças e adolescentes muitas vezes devido a hipertrofia de adenoides e das amígdalas palatinas. Ademais, é importante destacar que em pacientes com SAHOS observa-se que os músculos dilatadores da faringe estão mais ativados na vigia em relação ao controle, contudo, com o sono, há redução dos reflexos neuromusculares e consequentemente prejuízo da habilidade desses músculos em responder à pressão, o que deixa esses músculos vulneráveis para o colapso durante o sono e faz com que temos como resultado episódios de apneia obstrutiva do sono. Além disso, uma via aérea superior mais estreita, fatores genéticos, hipertrofia de amígdalas e adenoides, retrognatia mandibular e variações na estrutura craniofacial, estão associadas a um maior risco de desenvolvimento de SAOS. Sobre o diagnostico o estudo polissonográfico de noite inteira é o principal método diagnostico, sendo que esse ainda possibilita ao medico classificar a gravidade do problema. Sobre o tratamento destaca-se que é um tratamento abrangente que vai desde cirurgias até o uso de aparelhos como o CPAP e dispositivos intraorais.
CORRELAÇÃO DO USO DO ÓLEO DE CANABIDIOL COM A REGULAÇÃO E MANUTENÇÃO DA HOMEOSTASE CORPORAL
Authors: Diniz Camilla Borja de Siqueira , Fernanda Prado de Mello  , Araújo Neto Francisco Jazon de , Lopes Karoline Maciel , Pires Maria Luiza Pedroni , Bahia Renata de Araújo Lins , Nascimento Sheila Maria de Luna , De Lima Rafael Espósito
Published: December 2023

OBJETIVOS: Correlacionar o uso da Cannabis sativa, seus efeitos terapêuticos, na manutenção e regulação da homeostase corporal. METODOLOGIA: Este estudo é uma revisão de literatura qualitativa, exploratória, baseada em uma pesquisa bibliográfica na plataforma PubMed. Sendo assim, seis estudos foram escolhidos, lidos integralmente e analisados para esta pesquisa. RESULTADOS/DISCUSSÃO: Os estudos elencados para essa revisão foram publicados nos anos de 2019 a 2023, sendo que 50% deles foram publicados no ano de 2022. A maioria dos trabalhos eram dos Estados Unidos 33,3%, contra 16,7% da Suiça, 16,7% do Canadá, 16,7% da Turquia e 16,7% de Israel. Foram observados em diversos estudos, que tais níveis de concentração circulantes de endocanabinóides, quando elevados, ativam a via anti-inflamatória colinérgica, e, por conseguinte, diminuem e previnem o estresse oxidativo associado a fisiopatogênese de doenças como ansiedade, depressão, obesidade e diabetes. Assim, apresenta que os endocanabinóides e a expressão de receptores endocanabinóides CB1 e CB2 como fundamentais no processo de regulação das respostas imunológicas inatas e adaptativas. Outros, correlacionam a modulação da resposta imunológica das vias aéreas a expressão de receptores CB1 e CB2, sugerindo que ligantes de receptores endocanabinóides apropriados possam vir a ser empregados no tratamento de asma devido seus efeitos anti-inflamatórios e broncodilatadores. Nesse sentido, corroborando os dados apresentados por um estudo, que aponta fortes evidências acerca da aplicabilidade da terapêutica envolvendo a modulação endocanabinóide e a sinalização dos receptores CB1 como um regulador da fisiologia do tecido adiposos com potencial de combate a obesidade. CONCLUSÃO: Este sistema não apenas regula o sistema nervoso central, mas também desempenha papel crucial na modulação de respostas imunológicas, físicas e metabólicas. Conclui-se que os impactos gerados pelo exercício físico no sistema de sinalização endocanabinoide representam uma abordagem não farmacológica promissora. Além disso, esses resultados fornecem uma base sólida para o desenvolvimento futuro de pesquisas que visam aprofundar o entendimento acerca do papel dos sistemas endocanabinoides.
ATUAÇÃO DO ENFERMEIRO MEDIANTE DOENÇAS HIPERTENSIVAS ESPECIFICAS DA GESTAÇÃO NA ATENÇÃO PRIMÁRIA À SAÚDE: REVISÃO INTEGRATIVA
Authors: Silva Joyce Karollayne da , Silva Andreza Correia Dourado da , Viana Rayane Larissa de Melo , Vieira Aparecida Xavier da Silva , Ribeiro Mayra Aparecida Mendes , Silva Bruna Barros da , Silva Solania Barbosa de Brito Soares da , Souza Jocean Serafim dos Santos , Silva Adriele Carvalho da , Matos Paula Mariana Ferreira
Published: December 2023

Este artigo tem por objetivo avaliar a qualidade da assistência e dos cuidados prestados pelos enfermeiros da APS à gestante de alto risco. Para o encontro das literaturas realizou-se uma busca na base de dados da Biblioteca Virtual em Saúde através dos descritores “Cuidado pré-natal, Atenção primária à saúde, Pré-eclâmpsia e Hipertensão induzida pela gravidez”. Um conjunto de evidências sugere a qualificação profissional dos enfermeiros para atuarem com autonômia e conhecimento científico para obter uma intervenção adequada à mulher com DHEG. Conclui-se que para reduzir os indices de morte do binômio materno-fetal, é necessário ter um enfermeiro competente e qualificado para identificar os riscos à saúde.
Avaliação da Resistência à Compressão de Materiais Restauradores com Propriedades Bioativas
Authors: Vaz da Silveira Millena Luiza , Rodrigues dos Santos Gislene , Da Mota Martins Victor , Soares de Andrade Rodrigo , Carvalho Montes Tatiana
Published: December 2023

A doença cárie, é uma doença de alta prevalência em todo o mundo principalmente na população infantil, que tem como consequência a dissolução da hidroxiapatita. Um composto com capacidade de prevenir ou reduzir a incidência de cárie é o flúor, dessa forma, cada vez mais tem-se desenvolvido e estudado materiais restauradores com uma capacidade de liberação desse composto, como é o caso da Beautifil II (GIOMER –Shofu); faz parte da família dos materiais GIOMER. Objetivo: Esse material tem despertado questionamentos acerca das suas propriedades mecânicas, por apresentarem características e composições diferentes dos mais utilizados, sendo necessário assim estabelecer as suas reais propriedades e benefícios quando comparados com outros materiais restauradores. Metodologia: O presente estudo buscou analisar por meio de um studo in vitro, a resistência a fratura de uma resina com propriedades de liberação de íons fluoreto e outros (Beautifil II), em comparação com outros dois materiais de mesma função. Resultados: Inquestionavelmente, a resistência e a longevidade dos procedimentos restauradores estão muito ligadas as propriedades mecânicas do material e a capacidade desse de evitar cáries secundárias. As resinas Beautifil II da familia dos materiais GIOMER , um material bioativo que possibilita a recarga e liberação de íons multi-funcionais, utilizando a tecnologia S-PRG (Ionômero de Vidro Pré-Reagido), promove além da liberação de flúor a liberação de seis outros tipos de íons, cada qual com sua propriedade. Conclusão: Apesar da diferença na composição, as resinas Beautifil II se comparam com as resinas compostas convencionais (Z350 – 3M).
Relatability's role in formative assessment and feedback practices of young Black academics in an access university
Authors: Sitto-Kaunda Karabo , Moroeng Ofentse , Makhubela Tebogo
Published: December 2023

Transformation and diversification efforts in South African higher education system continue thirty years into democracy. Access universities play a crucial role in attracting students from previously excluded groups to higher education, specifically Black learners from poor schools with the least resources. Black lecturers in access universities, through shared cultural identities and backgrounds, carry an unspoken responsibility, beyond academic duties, to develop inclusive assessment and feedback practices. This unspoken responsibility must be carried out without compromising academic curriculum requirements and became acutely important during the COVID-19 lockdown period. Through transdisciplinary pragmatism in pedagogical practice, relatability ensures that students engage in meaning-making through participation in the development of solutions that address hyper-localised problems, thus contextualising science in real-world contexts. This study evaluates the role of relatability in the development of inclusive, transdisciplinary, and pragmatic formative assessment and feedback practices for student success in higher education. It does this by comparing the practices and experiences of young, Black lecturers in an access university. Our formative assessment and feedback methodologies and analysis of our teaching portfolios are presented to demonstrate how our personal student experiences have shaped more inclusive practices. In the discussion, we highlight the influence of unspoken responsibilities on Black lecturers to develop student outcomes beyond academic success through assessment and feedback. We seek to highlight how relatability can be leveraged to improve formative assessment and feedback practices towards strengthening inclusive teaching and learning for students’ academic success.