bluuebunny/crossref_metadata_2025 huggingface dataset:
SARIK - framework para automatizar a segurança em ambientes de orquestração kubernetes
Authors: Santos Jonathan G. P. dos , Rocha Filho Geraldo P. , Gonçalves Vinícius P.
Published: September 2022

Este artigo apresenta o SARIK, um framework de segurança automática de regras de Iptables em ambientes de orquestração Kubernetes. O SARIK foi desenvolvido em shell script e foi utilizada o IDE Microsoft Visual Studio como ferramenta para codificação do software, a escolha da linguagem está relacionada por sua presença na maioria das plataformas de cloud. Portanto, não haverá a necessidade de instalação de dependência para que o framework funcione. O SARIK possibilita a rápida proteção da camada node através da configuração automática de regras de firewall nos inúmeros PODs (Pods são os menores e mais básicos objetos implantáveis no Kubernetes) contidos em um cluster. Por meio de bloqueio e abertura de portas, o SARIK realiza uma inspeção em cada node, armazenando suas portas e bloqueando aquelas que podem trazer riscos aos containers. Em outras palavras, o desenvolvedor não precisa proteger seus containers, essa tarefa é feita pelo SARIK. O funcionamento do SARIK é avaliado em um ambiente controlado com minikube e uma aplicação de votação contendo deployment, namespace e services. Com a utilização do SARIK, desenvolvedores alcançam a redução de trabalho manual devido a automatização das regras de iptables e com isso, a proteção da camada node é garantida.
Formalisierung des Informellen. Die Regulierung der „24-Stunden-Betreuung“ in Österreich und Deutschland
Authors: Leber Simone , Österle August
Published: September 2022

Seit der EU-Osterweiterung findet Pflege- und Betreuungsarbeit durch Migrant*innen aus Mittel- und Osteuropa, die im Haushalt der Pflegebedürftigen leben (Live-in-Modell), zunehmend Verbreitung in familialistisch geprägten Wohlfahrtsstaaten wie Österreich und Deutschland. Der Beitrag stellt die Verbreitung und rechtliche Rahmung des Phänomens in den beiden Ländern dar und erläutert die Genese und Bedeutung der Live-in-Arrangements im Gesamtkontext der Pflege in Privathaushalten. Die Ursprünge der neuen Sorgemärkte beruhten zunächst auf informellen Netzwerken und Arrangements. Während in Österreich das Feld im Jahr 2007 umfassend reguliert wurde, gab es in Deutschland bisher keine politische Regulierung des grauen Marktes. In beiden Ländern sind aber Pflegeagenturen als politische Akteure aktiv und initiieren Prozesse unternehmerischer Selbstregulierung. Der Beitrag geht im Ländervergleich der Frage nach, welches die politischen Triebkräfte dieser Regulierungs- und Formalisierungsprozesse waren, was die unterschiedlichen Entwicklungen in den beiden Ländern erklärt und welche politische Rolle dabei die Vermittlungsagenturen und ihre Interessenorganisationen spielen.
Auswirkungen der Covid-19-Pandemie auf informell Pflegende in Europa. Ergebnisse einer Befragung
Authors: Lamura Giovanni , Quattrini Sabrina , Santini Sara , Rosa Mirko Di , Yghemonos Stecy , Socci Marco
Published: September 2022

In dem Beitrag werden die Ergebnisse einer Online-Umfrage informeller Pflegepersonen in Europa vorgestellt. Ziel dieser Studie, die von Eurocarers in Zusammenarbeit mit dem italienischen National Institute of Health and Science on Ageing (INRCA IRCCS) gefördert wurde, war es zu analysieren, wie sich der Covid-19-Ausbruch auf die Bedingungen informeller Pflegekräfte auswirkte, und die Wünsche dieser Pflegepersonen hinsichtlich einer besseren Unterstützung in Pandemiezeiten zu erheben. Die Gelegenheitsstichprobe umfasste 2468 Betreuer aus 17 Ländern, wobei die meisten Befragten aus Tschechien, Estland, Finnland, Deutschland, Italien, Portugal und Schweden antworteten. Aus den Ergebnissen können Handlungsempfehlungen in verschiedenen Bereichen abgeleitet werden: ein ausgewogener Zugang von pflegenden Angehörigen zum Arbeitsmarkt (z. B. durch Anerkennung ihrer Betreuungskompetenzen) ; Stärkung der Strategien zur Vereinbarkeit von Beruf und Privatleben ; Sicherstellung von Rentengutschriften auf der Grundlage von Pflegezeiten ; Förderung integrierter Dienste und Informationen ; Einbindung informeller Pflegekräfte als Mitgestalter von Fördermaßnahmen, auch durch nutzerfreundliche digitale Lösungen.
Strafrecht – Allgemeiner Teil
Authors: Kaspar Johannes
Published: September 2022

Für die Neuauflage wurde das Buch vollständig durchgesehen und auf den neuesten Stand gebracht. Eine Vielzahl von neueren (vor allem didaktischen) Aufsätzen wurde ebenso eingearbeitet wie die seit der letzten Auflage ergangenen wichtigsten höchstrichterlichen Entscheidungen, darunter beispielsweise die Entscheidung des BGH zum „dolus alternativus“.

Aktualisiert und erweitert wurden auch die Querverweise auf das nunmehr schon in 2. Auflage erschienene „Casebook Strafrecht Allgemeiner Teil“. Es stellt die ideale Ergänzung zum vorliegenden Lehrbuch dar.
Chaos Analysis Framework: How to Safely Identify and Quantify Time-Series Dynamics
Authors: Vogl Markus
Published: September 2022

Within this chapter, a practical introduction to a nonlinear analysis framework tailored for time-series data is provided, enabling the safe quantification of underlying evolutionary dynamics, which describe the referring empirical data generating process. Furthermore, its application provides the possibility to distinct between underlying chaotic versus stochastic dynamics. In addition, an optional combination with (strange) attractor reconstruction algorithms to visualize the denoted system’s dynamics is possible. Since the framework builds upon a large variety of algorithms and methods, its application is by far trivial, especially, in hindsight of reconstruction algorithms for (strange) attractors. Therefore, a general implementation and application guideline for the correct algorithm specifications and avoidance of pitfalls or other unfavorable settings is proposed and respective (graphical) empirical examples are shown. It is intended to provide the readers the possibility to incorporate the proposed analysis framework themselves and to conduct the analyses and reconstructions properly with correct specifications and to be knowledgeable about misleading propositions or parameter choices. Finally, concluding remarks, future avenues of research and future refinements of the framework are proposed.
Management of Spasticity and Cerebral Palsy Update
Authors: Awaad Yasser
Published: September 2022

Cerebral palsy is a very common medical problem, which has many challenges facing patients, family, caregivers, and medical team. The fast-based technology helped us to find new ways to manage and treat cerebral palsy. Treatment and management is a multi-disciplinary approach to reaching the optimal results. The managing team includes a general pediatrician, pediatric neurologist, pediatric rehabilitation, pediatric neurosurgeon, pediatric orthopedic surgeon, and other ancillary medical services. In our management plan, we have to consider the patient, family, and caregivers as parts of our plan. Raising awareness in the communities especially young mothers and general pediatricians to recognize the problem early and seek medical help and also early referrals to specialized centers will help to have early intervention and obtain better results.
Inflammatory Diseases and the Role of n-7 Unsaturated Fatty Acids as Functional Lipids
Authors: Nakamura Akio , Nakamura Hikari , Kawaharada Ritsuko
Published: September 2022

With the increasing childbearing age, the number of mothers with diabetes and gestational diabetes is escalating. Maternal hyperglycemia creates an intrauterine hyperglycemic environment via the placenta, which causes signaling abnormalities in various fetal organs due to excessive glycation. This is associated with future disease development in the child. We have shown that insulin signaling defects are induced in fetal cardiomyoblasts using a rat gestational diabetes mellitus model and cellular models. Furthermore, we reported that maternal intake of eicosapentaenoic acid (EPA), an n-3 unsaturated fatty acid, during pregnancy can ameliorate this signaling defect. However, EPA has anti-coagulant effects, and the pollution of marine fish oil, the source for EPA supplements, raises concerns about active intake by pregnant women. Recently, palmitoleic acid, an n-7 unsaturated fatty acid, garnered attention as a candidate functional lipid alternative to EPA because it has been reported to have anti-obesity, lipid metabolism improvement, and cardioprotective effects similar to those of EPA. Palmitoleic acid has cis and trans structural isomers, which differ in their food intake route and metabolism in humans. This article introduces recent findings on the biological functions of palmitoleic acid in lifestyle-related diseases and cardiovascular diseases, ranging from basic research to clinical studies.
Perspective Chapter: Ameloblastoma – Present and Future Concepts of Managing
Authors: Gabrić Dragana , Bjelica Roko , Sušić Mato , Vuletić Marko
Published: September 2022

Ameloblastoma is a benign odontogenic tumor of epithelial origin with locally aggressive behavior. It affects a broad age range of patients and it is most commonly found in the mandible, especially posterior area. The majority of ameloblastomas are conventional (multicystic), which are more difficult to eradicate than the unicystic or peripheral types. Although most of ameloblastoma cases can be treated predictably with radical surgical treatment, the management of recurrent and metastasizing ameloblastomas remains a major challenge. Surgical treatment is standard, but the extent of resection is controversial. Radical resection with segmental and marginal mandibulectomy or curettage and enucleation with better quality of life, but with higher recurrence rate. Besides the conventional surgical treatment, novel therapy options like neoadjuvant molecular targeted therapy and decompression in young patients could make a significant improvement in the management of the disease. The aim of this chapter was to determine the present and future concepts of treatment and discuss significant factors responsible for recurrence.
Study on Laser Welding of Dissimilar Materials between Aluminum and Copper (Ⅰ) - Research Trend in Laser Welding Technology and Materials Testing Methods -
Authors: Kim Yong , Jeong Su Jin , Yun Seong Min , Lee Je In
Published: September 2022

In the rapidly changing automobile market, the important issues in assembling electric vehicles (EVs) can be summarized as weight reduction and battery safety. For the battery manufacturing technology, welding of dissimilar materials is crucial to assure the functionality and reliability of the battery systems installed in the recently developed EVs. This paper discusses research trends in laser welding technology for joining Al and Cu, which is currently applied for the joining process in the battery pack manufacturing. Laser welding of Al/Cu is well known to be very difficult owing to the formation of brittle intermetallic compounds as well as the low absorption rate of laser beam in both Al and Cu. Thus, the energy absorption rate, optimal energy density (beam size), welding heat input, beam modulation, and laser wavelength should be carefully optimized. The quality of dissimilar Al/Cu laser welding has been assessed by evaluating tensile and electrical properties. However, no standardized testing method exists for the laser welded materials. Therefore, standards must be urgently established for the mechanical and electrical evaluation of the laser welded materials. From the tear-down analysis of commercially produced battery modules in domestic EV, the quality of Al/Cu and Cu/Cu laser welds is critically assessed. For future research, the monitoring technology for reliable real-time laser welding should be developed for the mass-production of EV battery systems with better productivity and higher reliability.
Code-Switching By Multilingual Pakistanis On Twitter: A Qualitative Analysis
Authors: Jamali Javeria , Rasool Mishal , Batool Huma
Published: September 2022

Code-switching is practicing two different grammatical systems where multilinguals also move between two languages or between two dialects or registers of the same language. In the current article, code-switching is characterized as the simultaneous use of two or more languages or dialects within a conversation. The current study focused on code-switching practices on the social media website Twitter. While posting on Twitter, multilinguals may use several languages. The aim of this study was to describe and analyze code-switched Tweets for any recurring patterns and practices. The population of this study involved Twitter users living in the Rawalpindi-Islamabad area of Pakistan. The Tweets were collected on the basis of time and location through a random cluster sampling method. A qualitative analysis of the individual Tweets was done, and recurring patterns were pointed out. This was purely observational research. It was found that the sampled Tweets only code-switched between Urdu and English. Code-switching at the intra-sentential level was more common than at the inter-sentential level. Code-switching at the level of clauses was the most common form of intra-sentential code-switching. Over half of the inter-sentential code-switching had the English sentence(s) preceding the Urdu sentence(s). The findings suggest that code-switching between English and Urdu occurs more commonly at the intra-sentential level. They further imply that the population generally prefers to start inter-sentential code-switching with English before code-switching to Urdu. The results of this study may be useful in demystifying the phenomenon of code-switching in online spaces.
Searching for Sweetness
Authors: Hanisch Sarah
Published: September 2022

Traversing from the rapidly urbanising county-level city of Fuqing to the remote mountainous kingdom of Lesotho in Southern Africa, Searching for Sweetness is one of the first and most extensive ethnographies linking rural-to-urban migration in China with Chinese migration to Africa. Against the backdrop of China’s national struggle for modernity and globalisation, Sarah Hanisch examines Chinese migrant women’s complex and ever-shifting struggles for upward social mobility across different generations and localities in China and Lesotho. Embedding the women’s individual portraits into larger historical contexts, Hanisch illustrates how these women interpret and narrate their migratory and everyday experiences through and beyond powerful state meta-narratives on ‘sweetness’ and ‘bitterness’. In her exploration of migratory identities and projects which have been overlooked by previous studies, Hanisch brings uniquely gendered, multi-sited, and intergenerational perspectives to existing scholarship on Chinese internal and international migration.
Mechanical Thrombectomy in Acute Stroke Patients with Moderate to Severe Pre-Stroke Disability
Authors: Sykora Marek , Michel Patrik , Strambo Davide , Krebs Stefan , Ferrari Julia , Posekany Alexandra , Mikšová Dominika , Hermann Konstantin , Gattringer Thomas , Gizewski Elke , Deutschmann Hannes , Neumann Christian , Lang Wilfried
Published: September 2022

Background and Purpose Studies on mechanical thrombectomy (MT) in acute ischemic stroke (AIS) patients with preexisting disability are limited. We aimed to compare the outcomes of MT versus best medical treatment (BMT) in these patients. Methods In the nationwide Austrian registry and Swiss monocentric registry, we identified 462 AIS patients with pre-stroke disability (modified Rankin Scale [mRS] score ≥3) and acute large vessel occlusion. The primary outcome was returning to pre-stroke mRS or better at 3 months. Secondary outcomes were early neurological improvement (National Institutes of Health Stroke Scale score improvement ≥8 at 24 to 48 hours), 3-month mortality, and symptomatic intracerebral hemorrhage (sICH). Multivariable regression models and propensity score matching (PSM) were used for statistical analyses. Results Compared with the BMT group (n=175), the MT group (n=175) had younger age, more severe strokes, and lower pre-stroke mRS, but similar proportion of receiving intravenous thrombolysis. MT was associated with higher odds of returning to baseline mRS or better at 3 months (adjusted odds ratio [aOR], 2.5; 95% confidence interval [CI], 1.39 to 4.47), early neurological improvement (aOR, 2.62; 95% CI, 1.41 to 4.88), and lower risk of 3-month mortality (aOR, 0.29; 95% CI, 0.18 to 0.49). PSM analysis showed similar findings. MT was not associated with an increased risk of sICH (4.0% vs. 2.1% in all patients; 4.2% vs. 2.4% in the PSM cohort). Conclusions MT in patients with pre-stroke mRS ≥3 might improve the 3-month outcomes and short-term neurological impairment, suggesting that pre-stroke disability alone should not be a reason to withhold MT, but that individual case-by-case decisions may be more appropriate.
A thematic approach to selection effects and biases in cosmology: Fred Hoyle and the rejection of the big bang idea, despite the experimental observations
Authors: Barbosa João
Published: September 2022

Despite some important observations and after decades of widespread consensus around the big bang cosmology, Fred Hoyle, one of the proponents of the steady-state cosmology, continued to fight the big bang idea throughout his life. We can try to understand this persistent attitude of Hoyle through a Holtonian thematic approach, by admitting that personal preferences and choices of scientists are conditioned by themata. Thematic analysis shows that big bang cosmology is mainly based on a set of themata consisting of evolution, finitude, life cycle (which has a beginning), and change; the steady-state cosmology is based on opposite themata: steady-state, infinity, continuous existence, and constancy. Personal preferences seem to have been important in the strong and passionate dispute between big bang and steady-state ideas, and Hoyle is a very illustrative example of a personal commitment remarkably long-lived to some themata, in this case to the opposite themata of the big bang cosmology. In his personal and persistent struggle against the big bang idea, Hoyle always refused the way how some experimental observations were considered decisive in favor of this cosmology. This is a typical thematic attitude: letting some personal thematic preferences influence the acceptance or rejection of scientific evidence. In this case, that corresponds to the existence of selection effects and biases regarding important cosmological observations, in order to sustain a persistent rejection of the big bang idea.
Testing bond behaviour of an innovative triangular strand: Experimental setup challenges and preliminary results
Authors: Lazić Žarko , Marinković Snežana , Koković Veljko , Broćeta Gordana , Latinović Marina
Published: September 2022

The use of the seven-wire strand in pretension structures so far has shown that such strands have a relatively long development length. An attempt to reduce the development length is reflected through the idea of a different strand geometry that has a more favorable shape. This new shape should have a greater inclination of the outer wires, increasing the resistance that occurs when moving through the concrete. The idea is primarily about the triangular distribution of wires in the cross-section of the strand. This paper reviews tests related to the use of innovative, triangular, and ten-wire strands. The tests exclusively relate to the strands formed by the use of steel wires.
Seismic isolated house reaction upon condition of the repeatability of earthquakes
Authors: Lapin Vladimir , Sharipov Rashid , Aldakhov Yerkin
Published: September 2022

To study the seismic properties of buildings in Almaty, a special test site operates. It includes buildings with conventional strip foundations with a system of cross belts and seismic support of 2 types. The landfill buildings were previously tested under static and dynamic influences. With the use of real accelerograms of earthquakes, a forecast of the behavior of a seismically isolated house on kinematic foundations under seismic influences has been carried out. The seismic impact is represented by a set of real accelerograms of strong, mainly Californian earthquakes. The hearts depths and magnitudes correspond to possible Almaty earthquakes. Two design schemes of a seismically isolated building are considered - single-mass and 10-mass dynamic building models. It is shown that the magnitudes of displacements in the kinematic foundations (KF) level obtained by two dynamic models usually differ within 5-10%. Therefore, the calculation of seismically isolated buildings can be applied to a single-mass non-linear dynamic model. A linear regression connection was obtained between the values of acceleration at the base and displacements at the level of the foundation. For the values of acceleration according to the new "Map of seismic zoning of the Republic of Kazakhstan" were obtained the predicted values of displacement at the level of the kinematic support of the order of 8.0-11.5 cm.
Mucosal incision-assisted biopsy versus endoscopic ultrasound-assisted tissue acquisition for subepithelial lesions: a systematic review and meta-analysis
Authors: Giri Suprabhat , Afzalpurkar Shivaraj , Angadi Sumaswi , Sundaram Sridhar
Published: September 2022

Background/Aims: Mucosal incision-assisted biopsy (MIAB) for tissue acquisition (TA) from subepithelial lesions (SELs) is emerging as an alternative to endoscopic ultrasound (EUS)-guided TA. Only a limited number of studies compared the diagnostic utility of MIAB and EUS for upper gastrointestinal (GI) SELs; therefore, we conducted this systematic review and meta-analysis.Methods: A comprehensive literature search from January 2020 to January 2022 was performed to compare the diagnostic accuracy and safety of MIAB and EUS-guided TA for upper GI SELs.Results: Seven studies were included in this meta-analysis. The pooled technical success rate (risk ratio [RR], 0.96; 95% confidence interval [CI], 0.89–1.04) and procedural time (mean difference=–4.53 seconds; 95% CI, –22.38 to 13.31] were comparable between both the groups. The overall chance of obtaining a positive diagnostic yield was lower with EUS than with MIAB for all lesions (RR, 0.83; 95% CI, 0.71–0.98) but comparable when using a fine-needle biopsy needle (RR, 0.93; 95% CI, 0.83–1.04). The positive diagnostic yield of MIAB was higher for lesions <20 mm (RR, 0.75; 95% CI, 0.63–0.89). Six studies reported no adverse events.Conclusions: MIAB can be considered an effective alternative to EUS-guided TA for upper GI SELs without an increased risk of adverse events.
Hitos en la legitimación del Teatro para Audiencias Jóvenes en el Chile de la década del 2000
Authors: Villanueva Catalina , Fuente Héctor Ponce de la , Olivares Paulo , Rossel Camilo
Published: September 2022

En este artículo se identifican hitos cruciales para el desarrollo del Teatro para Audiencias Jóvenes (TPAJ) de la década del 2000 en Chile. Se presenta una visión sintética del TPAJ en Chile, reconociendo, en base a nociones Bourdianas, una tensión entre objetivos educativos y objetivos artísticos que ha implicado la deslegitimación de este tipo de creaciones. El artículo analiza entrevistas a agentes significativos del periodo para discutir cómo ciertos hitos contribuyeron a legitimar el TPAJ en el campo teatral chileno, buscando un balance entre educación y arte y enfatizando el respeto por la capacidad de sus audiencias de tener experiencias estéticas valiosas.
Change of obesity prevalence and lifestyle patterns before and during COVID-19 among Korean adolescents
Authors: Park Hong Kyu , Lim Jung Sub
Published: September 2022

Purpose: Lockdown measure for limiting coronavirus disease 2019 (COVID-19) spread cause an aggravation of the childhood obesity epidemic through lifestyle changes. The aim is to investigate how social restriction might have changed obesity prevalence and lifestyle patterns in Korean adolescents. We also evaluate the most fragile group and most influencing lifestyle parameters on obesity prevalence.Methods: To assess the change in weight status and lifestyle, we compared the Korea Youth Risk Behavior Web-based Survey data 2019 (pre-COVID-19, n=57,303) and 2020 (post-COVID-19, n=54,948). Participants from middle schools and high schools, aged 12 to 18 years, voluntarily reported their weight status and lifestyles.Results: The prevalence of obesity of the total subjects was 11.0% in 2019 and 12.1% in 2020. This prevalence difference varied by sex (males 1.8%, females 0.3%, p<0.001), age group (12–15 year 1.6%, 16–18 year 0.4%, p<0.001), and socioeconomic status. Male aged 12–15 years showed highest increase from 12.5% to 15.2%. Physical activities, fruit intake, consumption of sugar-sweetened beverages, and stress showed all decrease. Only, nonstudy sedentary time marked increased from 3.3±2.3 hr/day to 4.3±2.8 hr/day. Both moderate-intensity and vigorous-intensity physical activity marked decreased especially in male aged 12–15 years, while increased in female aged 16–18 years.Conclusion: Korean adolescents showed increasing obesity prevalence after COVID-19 lockdown, with males aged 12–15 years mainly affected, mainly due to a reduced physical activity and increased sedentary time.
Genetic obesity: an update with emerging therapeutic approaches
Authors: Sohn Young Bae
Published: September 2022

Based on the genetic contribution, childhood obesity can be classified into 3 groups: common polygenic obesity, syndromic obesity, and monogenic obesity. More genetic causes of obesity are being identified along with the advances in the genetic testing. Genetic obesities including syndromic and monogenic obesity should be suspected and evaluated in children with early-onset morbid obesity and hyperphagia under 5 years of age. Patients with syndromic obesity have early-onset severe obesity associated specific genetic syndromes including Prader-Willi syndrome, Bardet-Biedle syndrome, and Alstrom syndrome. Syndromic obesity is often accompanied with neurodevelopmental delay or dysmorphic features. Nonsyndromic monogenic obesity is caused by variants in single gene which are usually involved in the regulation of hunger and satiety associated with the hypothalamic leptin-melanocortin pathway in central nervous system. Unlike syndromic obesity, patients with monogenic obesity usually show normal neurodevelopment. They would be presented with hyperphagia and early-onset severe obesity with additional clinical symptoms including short stature, red hair, adrenal insufficiency, hypothyroidism, hypogonadism, pituitary insufficiencies, diabetes insipidus, increased predisposition to infection or intractable recurrent diarrhea. Identifying patients with genetic obesity is critical as new innovative therapies including melanocortin 4 receptor agonist have become available. Early genetic evaluation enables to identify treatable obesity and provide timely intervention which may eventually achieve favorable outcome by establishing personalized management.
The Impact of COVID-19 on Subjective Well-Being: Evidence from Twitter Data
Authors: Carpi Tiziana , Hino Airo , Iacus Stefano Maria , Porro Giuseppe
Published: September 2022

This study analyzes the impact of the COVID-19 pandemic on subjective well-being as measured through Twitter for the countries of Japan and Italy. In the first nine months of 2020, the Twitter indicators dropped by 11.7% for Italy and 8.3% for Japan compared to the last two months of 2019, and even more compared to their historical means. To understand what affected the Twitter mood so strongly, the study considers a pool of potential factors including: climate and air quality data, number of COVID-19 cases and deaths, Facebook COVID-19 and flu-like symptoms global survey data, coronavirus-related Google search data, policy intervention measures, human mobility data, macro economic variables, as well as health and stress proxy variables. This study proposes a framework to analyse and assess the relative impact of these external factors on the dynamic of Twitter mood and further implements a structural model to describe the underlying concept of subjective well-being. It turns out that prolonged mobility restrictions, flu and Covid-like symptoms, economic uncertainty and low levels of quality in social interactions have a negative impact on well-being.
Assessment of the Community Periodontal Index of Treatment Needs (CPITN) in Pregnant Women Referring to the Health Centers in Arak, Iran
Authors: BASHİRİAN Saeid , BARATİ Maryam , BARATİ Majid , KHAZAEİ Salman , JENABİ Ensiyeh , GHOLAMİ Leila , SHİRAHMADİ Samane
Published: September 2022

Objectives: The periodontal disease during pregnancy is considered to be significant because not only does it affect the tissues supporting the teeth, but also it is connected with systemic conditions such as adverse pregnancy outcomes. The present study aimed at assessing periodontal disease in pregnant women and other relevant demographic factors.

Materials and methods: This is a cross-sectional, descriptive-analytical study that was conducted among 275 pregnant women visiting the health centers in Arak, Iran, in 2021. Cluster random sampling method was used to select the samples. The demographic information was gathered and periodontal statues was examined using the Community Periodontal Index of Treatment Needs (CPITN). The data were analyzed by SPSS18 software, using logistic regression.
Results: According to the results, 55.4% of the pregnant women had periodontal disease (CPI>0). Bleeding on probing (BOP), dental calculus, and periodontal pocket depth (PPD) between 4 and 5 mm were observed of 17.5%, 36.4%, 5.1% of women, respectively. No periodontal pocket deeper than 6mm was observed. Brushing frequency was the main predictor for gingival health, and the women with under diploma education (OR: 2.26, 95% CI: 1.14-4.48) and having one or more children were (OR: 1.40, 95% CI: 1.02-1.94) more likely to have periodontal disease than women with academic education or having no children.
Conclusion: According to the findings, pregnant women were not in good health condition in terms of periodontal disease. Considering the demographic and behavioral differences, designing the health promotion programs during pregnancy is recommended.
Bielorrusia, Eurovisión y el debate internacional sobre la democracia: El impacto mediático de las candidaturas de la BTRC en el Festival de la Canción
Authors: Panea José Luis , Cámara-Rojo Ángela
Published: September 2022

Ante las multitudinarias protestas por el presunto fraude electoral de Aleksandr Lukashenko en 2020, el debate sobre la democracia en Bielorrusia está despertando gran interés internacional. La Unión Europea sanciona dichos comicios, el gobierno retira la acreditación a la prensa extranjera y las manifestaciones alcanzan gran difusión mediática. Además, las celebridades del ámbito de la cultura, como es el caso de algunos representantes del país en Eurovisión, se muestran como caras visibles de la revolución. De modo similar, anualmente la participación bielorrusa en el Festival ha resultado controvertida a causa de la politización de sus candidaturas ya desde sus conflictivas preselecciones nacionales para elegir a su representante, siendo finalmente el país expulsado del certamen en 2021 por la Unión Europea de Radiodifusión. Contrapondremos así dos dimensiones, la política y la cultural, en una competición que combina ambas a través de la construcción identitaria del concepto de nación en el marco de la cultura del espectáculo.
Laura Kipnis, Love in the Time of Contagion.
Authors: Aparisi Galán María
Published: September 2022

Laura Kipnis, Love in the Time of Contagion. Nueva York: Pantheon Books, 2022, 210 págs.
Antonio Ansón, Hijos del agobio. Memoria y desmemoria de la guerra en la fotografía española contemporánea
Authors: Ordóñez Fernández Rafael
Published: September 2022

Antonio Ansón, Hijos del agobio. Memoria y desmemoria de la guerra en la fotografía española contemporánea. Madrid: Producciones de Arte y Pensamiento, 2019, 179 págs.
Importancia de la regulación oficial en la vinculación académico-profesional: el caso de las técnicas de auditoría (primeros resultados)
Authors: Calvo Palomares Ricard , Aguado Hernández Juli Antoni , Sigalat Signes Enric , Payá Castiblanque Raúl
Published: September 2022

Uno de los objetivos subyacentes de la docencia universitaria actual es intentar conectarla con la realidad profesional con la que se van a encontrar los/as egresados/as con posterioridad en el mercado laboral. En materias muy aplicadas, la existencia de una regulación normativa oficial se convierte en un elemento clave para el éxito de cualquier propuesta docente realizada. Ante dicho contexto la presente investigación trata de estudiar el efecto de la normativa oficial sobre una propuesta de innovación educativa en Ciencia Laborales. A tal efecto, se usa una metodología cuantitativa mediante una encuesta por medio de un cuestionario estandarizado al alumnado de la asignatura de Técnicas de Auditoría de 3r curso del Grado de Relaciones Laborales y Recursos Humanos de la Facultad de Ciencias Sociales de la Universidad de Valencia, de los cursos 2017-2018 a 2020-2021 (n=311) que evalúa distintos aspectos relacionados con su grado de satisfacción con la metodología, las prácticas, los contenidos y los materiales de apoyo, así como con la percepción sobre la proyección de la asignatura en la esfera profesional. Los resultados obtenidos evidencian la importancia de la regulación oficial en la valoración de las dificultades a las que se enfrenta la auditoría sociolaboral, así como la existencia de asociación entre las variables de percepción de la utilidad de la asignatura y como una buena salida profesional con respecto a los cursos anteriores o posteriores a la nueva normativa, por lo que pude atribuirse en gran parte a esta circunstancia la modificación de las valoraciones.
Harmonisation of VAT in the Europe: Present and Future
Authors: Dmoch Wojciech , Kołodziej Bartłomiej , Mioduszewski Michał , Mudrecki Artur
Published: September 2022

The monograph is intended to create a platform for discussion on the most important issues concerning the reform and future of the VAT system in the European Community. It will be a place for an effective exchange of reflections and experiences, including in terms of highlighting and presenting to international audiences Poland’s positive experiences with mechanisms, such as split payments, reverse charge and Binding Tariff Information. Conclusions resulting from the scientific discussion will certainly be able to be used not only in national VAT legislation, but also in the practice of tax administration facing the difficult task of maintaining the budgetary effectiveness of VAT as the main source of state tax revenue
FDY İplikler Kullanılarak Üretilen Tekstil Yüzeylerinin Akustik Performanslarının İncelenmesi
Authors: ERDAL Beyzanur , SANCAK Erhan
Published: September 2022

Gürültü insan sağlığını tehdit eden günümüzün önemli sorunlarından biri olarak karşımıza çıkmaktadır. Gürültü her ne kadar öznel bir tabir olsa da belli başlı sesler herkes tarafından gürültü olarak algılanmaktadır. Endüstriyel gürültü buna örnek olarak gösterilebilmektedir. İnsanların gürültüden etkilenmelerini en az seviyeye indirebilmek ve gürültü kirliliğini önlemek amacıyla özel materyaller kullanılmaktadır. Bu materyallere, gözenekli materyaller arasında yer alan köpük ve tekstil malzemeleri örnek olarak verilebilmektedir. Bu çalışma kapsamında, tekstil sektöründe en çok kullanım oranına sahip olan polyester lifleri kullanılmıştır. Polyester liflerinden elde edilen ipliklerden çözgülü örme kumaş üretilip empedans tüp metoduyla ses yutum katsayısı tespit edilmiştir. Polyester iplikte 7 (yedi) farklı enine kesit şekli kullanılmıştır. Kullanılan ipliklerin bütün özellikleri aynı olup tek değişken parametre enine kesit şekilleridir. Üretimi gerçekleştirilen çözgülü örme kumaşların ise desenleri her kesitte aynıdır. İki farklı sıklık kullanılarak üretilen kumaşların ses yutum katsayısının tayini, empedans tüp metoduyla gerçekleştirilmiştir.
Functional brain reconfiguration during sustained pain
Authors: Lee Jae-Joong , Lee Sungwoo , Lee Dong Hee , Woo Choong-Wan
Published: September 2022

Pain is constructed through complex interactions among multiple brain systems, but it remains unclear how functional brain networks are reconfigured over time while experiencing pain. Here, we investigated the time-varying changes in the functional brain networks during 20 min capsaicin-induced sustained orofacial pain. In the early stage, the orofacial areas of the primary somatomotor cortex were separated from other areas of the somatosensory cortex and integrated with subcortical and frontoparietal regions, constituting an extended brain network of sustained pain. As pain decreased over time, the subcortical and frontoparietal regions were separated from this brain network and connected to multiple cerebellar regions. Machine-learning models based on these network features showed significant predictions of changes in pain experience across two independent datasets (n = 48 and 74). This study provides new insights into how multiple brain systems dynamically interact to construct and modulate pain experience, advancing our mechanistic understanding of sustained pain.
Macrophage innate training induced by IL-4 and IL-13 activation enhances OXPHOS driven anti-mycobacterial responses
Authors: Lundahl Mimmi LE , Mitermite Morgane , Ryan Dylan Gerard , Case Sarah , Williams Niamh C , Yang Ming , Lynch Roisin I , Lagan Eimear , Lebre Filipa M , Gorman Aoife L , Stojkovic Bojan , Bracken Adrian P , Frezza Christian , Sheedy Frederick J , Scanlan Eoin M , O'Neill Luke AJ , Gordon Stephen V , Lavelle Ed C
Published: September 2022

Macrophages are a highly adaptive population of innate immune cells. Polarization with IFNγ and LPS into the ‘classically activated’ M1 macrophage enhances pro-inflammatory and microbicidal responses, important for eradicating bacteria such as Mycobacterium tuberculosis. By contrast, ‘alternatively activated’ M2 macrophages, polarized with IL-4, oppose bactericidal mechanisms and allow mycobacterial growth. These activation states are accompanied by distinct metabolic profiles, where M1 macrophages favor near exclusive use of glycolysis, whereas M2 macrophages up-regulate oxidative phosphorylation (OXPHOS). Here, we demonstrate that activation with IL-4 and IL-13 counterintuitively induces protective innate memory against mycobacterial challenge. In human and murine models, prior activation with IL-4/13 enhances pro-inflammatory cytokine secretion in response to a secondary stimulation with mycobacterial ligands. In our murine model, enhanced killing capacity is also demonstrated. Despite this switch in phenotype, IL-4/13 trained murine macrophages do not demonstrate M1-typical metabolism, instead retaining heightened use of OXPHOS. Moreover, inhibition of OXPHOS with oligomycin, 2-deoxy glucose or BPTES all impeded heightened pro-inflammatory cytokine responses from IL-4/13 trained macrophages. Lastly, this work identifies that IL-10 attenuates protective IL-4/13 training, impeding pro-inflammatory and bactericidal mechanisms. In summary, this work provides new and unexpected insight into alternative macrophage activation states in the context of mycobacterial infection.
Arnold tongue entrainment reveals dynamical principles of the embryonic segmentation clock
Authors: Sanchez Paul Gerald Layague , Mochulska Victoria , Mauffette Denis Christian , Mönke Gregor , Tomita Takehito , Tsuchida-Straeten Nobuko , Petersen Yvonne , Sonnen Katharina , François Paul , Aulehla Alexander
Published: September 2022

Living systems exhibit an unmatched complexity, due to countless, entangled interactions across scales. Here, we aim to understand a complex system, that is, segmentation timing in mouse embryos, without a reference to these detailed interactions. To this end, we develop a coarse-grained approach, in which theory guides the experimental identification of the segmentation clock entrainment responses. We demonstrate period- and phase-locking of the segmentation clock across a wide range of entrainment parameters, including higher-order coupling. These quantifications allow to derive the phase response curve (PRC) and Arnold tongues of the segmentation clock, revealing its essential dynamical properties. Our results indicate that the somite segmentation clock has characteristics reminiscent of a highly non-linear oscillator close to an infinite period bifurcation and suggests the presence of long-term feedbacks. Combined, this coarse-grained theoretical-experimental approach reveals how we can derive simple, essential features of a highly complex dynamical system, providing precise experimental control over the pace and rhythm of the somite segmentation clock.
Dynamic allostery in substrate binding by human thymidylate synthase
Authors: Bonin Jeffrey P , Sapienza Paul J , Lee Andrew L
Published: September 2022

Human thymidylate synthase (hTS) is essential for DNA replication and therefore a therapeutic target for cancer. Effective targeting requires knowledge of the mechanism(s) of regulation of this 72 kDa homodimeric enzyme. Here, we investigate the mechanism of binding cooperativity of the nucleotide substrate. We have employed exquisitely sensitive methyl-based CPMG and CEST NMR experiments enabling us to identify residues undergoing bifurcated linear 3-state exchange, including concerted switching between active and inactive conformations in the apo enzyme. The inactive state is populated to only ~1.3%, indicating that conformational selection contributes negligibly to the cooperativity. Instead, methyl rotation axis order parameters, determined by 2H transverse relaxation rates, suggest that rigidification of the enzyme upon substrate binding is responsible for the entropically-driven cooperativity. Lack of the rigidification in product binding and substrate binding to an N-terminally truncated enzyme, both non-cooperative, support this idea. In addition, the lack of this rigidification in the N-terminal truncation indicates that interactions between the flexible N-terminus and the rest of the protein, which are perturbed by substrate binding, play a significant role in the cooperativity—a novel mechanism of dynamic allostery. Together, these findings yield a rare depth of insight into the substrate binding cooperativity of an essential enzyme.
Rabphilin 3A binds the N-peptide of SNAP-25 to promote SNARE complex assembly in exocytosis
Authors: Li Tianzhi , Cheng Qiqi , Wang Shen , Ma Cong
Published: September 2022

Exocytosis of secretory vesicles requires the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins and small GTPase Rabs. As a Rab3/Rab27 effector protein on secretory vesicles, Rabphilin 3A was implicated to interact with SNAP-25 to regulate vesicle exocytosis in neurons and neuroendocrine cells, yet the underlying mechanism remains unclear. In this study, we have characterized the physiologically relevant binding sites between Rabphilin 3A and SNAP-25. We found that an intramolecular interplay between the N-terminal Rab-binding domain and C-terminal C2AB domain enables Rabphilin 3A to strongly bind the SNAP-25 N-peptide region via its C2B bottom α-helix. Disruption of this interaction significantly impaired docking and fusion of vesicles with the plasma membrane in rat PC12 cells. In addition, we found that this interaction allows Rabphilin 3A to accelerate SNARE complex assembly. Furthermore, we revealed that this interaction accelerates SNARE complex assembly via inducing a conformational switch from random coils to α-helical structure in the SNAP-25 SNARE motif. Altogether, our data suggest that the promotion of SNARE complex assembly by binding the C2B bottom α-helix of Rabphilin 3A to the N-peptide of SNAP-25 underlies a pre-fusion function of Rabphilin 3A in vesicle exocytosis.
Using logical constraints to validate statistical information about disease outbreaks in collaborative knowledge graphs: the case of COVID-19 epidemiology in Wikidata
Authors: Turki Houcemeddine , Jemielniak Dariusz , Hadj Taieb Mohamed A. , Labra Gayo Jose E. , Ben Aouicha Mohamed , Banat Mus’ab , Shafee Thomas , Prud’hommeaux Eric , Lubiana Tiago , Das Diptanshu , Mietchen Daniel
Published: September 2022

Urgent global research demands real-time dissemination of precise data. Wikidata, a collaborative and openly licensed knowledge graph available in RDF format, provides an ideal forum for exchanging structured data that can be verified and consolidated using validation schemas and bot edits. In this research article, we catalog an automatable task set necessary to assess and validate the portion of Wikidata relating to the COVID-19 epidemiology. These tasks assess statistical data and are implemented in SPARQL, a query language for semantic databases. We demonstrate the efficiency of our methods for evaluating structured non-relational information on COVID-19 in Wikidata, and its applicability in collaborative ontologies and knowledge graphs more broadly. We show the advantages and limitations of our proposed approach by comparing it to the features of other methods for the validation of linked web data as revealed by previous research.
The validity and reliability of the Test of Memory Strategies among Italian healthy adults
Authors: Vaccaro Maria Grazia , Liuzza Marco Tullio , Pastore Massimiliano , Paúl Nuria , Yubero Raquel , Quattrone Andrea , Antonucci Gabriella , Gambardella Antonio , Maestú Fernando
Published: September 2022

Background

Previous literature has shown that executive functions (EF) are related to performance in memory (M) tasks. Nevertheless, there is a shortage of psychometric tests that examine these two constructs simultaneously. The Test of Memory Strategies (TMS; previously validated in Spain and Portugal) could be a useful verbal learning task that evaluates these two constructs at once. In this study, we aimed to evaluate the psychometric properties of the TMS in an Italian adult sample.

Method

One hundred twenty-one healthy volunteers (74 F, Mean age = 45.9 years old, SD = 20.4) who underwent a neuropsychological examination participated in this study. We conducted a Confirmatory factor analysis (CFA) to evaluate the structural validity of the TMS. We conducted a latent variable analysis to examine convergent and discriminant validity of the TMS sub-scale scores reflecting executive functions and memory. We also examined the TMS reliability in terms of internal consistency through the McDonald’s omega.

Results

The CFA confirmed the expectation that the TMS-1 and TMS-2 subtests reflect a factor and that the TMS-3, TMS-4, and TMS-5 subtests reflect a different factor. This result is in line with the prediction that TMS-1 and TMS-2 require the use of executive functions and memory simultaneously, and therefore we called this factor executive functions (EF); whereas the TMS-3, TMS-4, and TMS-5 subtests require less involvement of executive functions, thus reflecting a construct that we named memory (M). The TMS subtests for EF and M showed convergent validity with the test scores using a traditional neuropsychological battery, assessing memory and executive functions separately. Finally, the reliability of the subtests was good.

Conclusions

These preliminary findings suggest that TMS is a valid and reliable scale to simultaneously assess M and EF while among Italian healthy adults.