bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Agricultural CO2 Emissions in Henan Province, China, Based on EKC and Decoupling
Authors: Wang Zhenjie , Lv Donghui
Published: February 2022

Global warming caused by greenhouse gas emissions is highly concerning. Both the environmental Kuznets curve (EKC) hypothesis and decoupling analysis indicate a dynamic relationship between economic growth and environmental pollution, and each method has its own emphasis. The objective of this paper is to investigate the nexus between grain production and agricultural carbon emissions for the main grain-producing areas in China. Taking Henan Province, the second largest agricultural province, as an example, this paper examines the relationship between grain production and agricultural CO2 emissions during 2000–2019, using the EKC hypothesis and decoupling analysis. The results are as follows: (1) The estimation model of CO2 EKC shows the climbing stage of an inverted U-shaped relationship, which suggests that agricultural economic growth occurred at the cost of an increase in agricultural CO2 emissions in Henan Province during the past 20 years. (2) The results of the decoupling analysis show that incidences of weak decoupling and expansive coupling states took up most of the study period, accompanied by an occasionally strong decoupling state; decoupling and coupling states alternated irregularly, and no clear development trends were observed. (3) Considering the shape of the CO2 EKC and the decoupling state, environmental policies encouraged decoupling, but suffered from time lags and poor continuity; long-term incentives, such as an ecological compensation policy, could perhaps drive carbon emission reduction. On this basis, Chinese agricultural policy should combine environmentally targeted interventions with measures supporting production and farmers’ incomes, and environmental policy should also adapt to economic growth. Only when both supplement each other can sustainable agricultural goals be achieved.
Hydrodynamic Response of Ocean-Towed Cable-Array System under Different Munk Moment Coefficients
Authors: Zhang Dapeng , Zhao Bowen , Zhu Keqiang
Published: February 2022

The ocean towing system plays an important role in the ocean development process. The motion of a towed body is closely coupled with the motion of a towing cable. In this paper, the lumped mass method is used to discrete a towing cable into a lumped mass model. At the same time, on the basis of some assumptions, the relationship between the expression of Munk moments in the classical towed body kinematics and the expression of the Munk moments in the hydrodynamic analysis software OrcaFlex is established. Based on the above assumptions and the derivation, combined with the specific parameters of a certain sea state and a certain towing system, the dynamic simulation of the towing system is made by OrcaFlex. By changing the different Munk moment coefficients, the real-time response of the cable tension and the towed underwater body under different Munk moments is achieved. The effects of different Munk moment coefficients on the change of the tension are obtained; the six degrees of freedom of the towed body under the action of different Munk moment coefficients are shown. To obtain the spectral density of the six degrees of freedom of the towed body under the action of different Munk moment coefficients, Fast Fourier Transform is performed on the calculated results of the towed body in the time domain. The results provide a theoretical basis for the optimal design of a cable and towed body.
Social Sustainability?: Exploring the Relationship between Community Experience and Perceptions of the Environment
Authors: Cope Michael R. , Kernan Ashley R. , Sanders Scott R. , Ward Carol
Published: February 2022

This study uses the Rural Utah Community Study (RUCS) to explore how social sustainability shapes a community’s approach to environmental sustainability. The results indicate that respondents who feel attached to and are satisfied with their community had a more positive relationship with the natural environment than those who were dissatisfied with their communities. We also find evidence that social ties, measured by the number of people known by their first name in the community, positively influence perceptions of the environment, and that a significant link exists between environmental sustainability and a higher sense of community belonging.
University as a Site to Learn Citizenship from the Perspectives of Students in the UK
Authors: Yang Jinyu , Kinchin Gary
Published: February 2022

The role of universities in preparing students to be active citizens within civil society has gained increasing attention. However, only limited research has been conducted on students’ views of universities as sites to learn representative democracy. To address the research gap, this article conducts eight semi-structured interviews with staff, student leaders and students without any positions in a case university. The students are undergraduate and post-graduate from different academic majors. Community of practice theory is employed to help understand students’ views of their experiences of representative democracy at the university. After analysing the interview data, the article finds that student leaders regard their role as mainly representing students and that all students in the study realise the importance of such democratic representation through participation. Importantly, through participation in representative democracy, students, especially student leaders, gain knowledge and skills on voting and elections. Interestingly, students’ sense of belonging is a result of participation in student union, society and club activities, which very likely includes voting and engagement with elections. Learning and belongingness are likely to make students participate more in future democratic representation activities. Although students give credit to the university’s role in promoting representative democracy, there are challenges. Specifically, the university is supposed to promote more participation in voting and elections for first-year students, and there is also concern that the short-term nature of positions in the student union may not allow real changes to be made. The findings shed some light on how students learn representative democracy in universities in neoliberal countries.
Polyacrylamide Functionalized Graphene Oxide/Alginate Beads for Removing Ciprofloxacin Antibiotics
Authors: Choi Jung-Weon , Choi Sang-June
Published: February 2022

Ciprofloxacin (CPX), a widely used antibiotic, was removed by synthesizing graphene oxide/calcium alginate–polyacrylamide (GO/Ca-Alg2–PAM) beads, a three-dimensional double-network complex. The synthesis of GO/Ca-Alg2–PAM beads was performed by crosslinking and cation exchange mechanisms with graphene oxide (GO), sodium alginate (Na-Alg), and polyacrylamide (PAM). The properties of GO/Ca-Alg2–PAM beads were confirmed using field emission scanning electron microscopy, Fourier transform infrared spectroscopy, and a thermogravimetric analysis. Furthermore, isothermal adsorption experiments were performed and fitted using three isothermal adsorption models (Langmuir, Freundlich, and Temkin). The adsorption isotherm experimental data fit well with the Langmuir isotherm model with a qm value of 6.846 mg/g. In addition, the spontaneous reaction of the CPX adsorption using GO/Ca-Alg2–PAM was confirmed by temperature-dependent experiments.
A Highly Specific Holin-Mediated Mechanism Facilitates the Secretion of Lethal Toxin TcsL in Paeniclostridium sordellii
Authors: Vidor Callum J. , Hamiot Audrey , Wisniewski Jessica , Mathias Rommel A. , Dupuy Bruno , Awad Milena , Lyras Dena
Published: February 2022

Protein secretion is generally mediated by a series of distinct pathways in bacteria. Recently, evidence of a novel bacterial secretion pathway involving a bacteriophage-related protein has emerged. TcdE, a holin-like protein encoded by toxigenic isolates of Clostridioides difficile, mediates the release of the large clostridial glucosylating toxins (LCGTs), TcdA and TcdB, and TpeL from C. perfringens uses another holin-like protein, TpeE, for its secretion; however, it is not yet known if TcdE or TpeE secretion is specific to these proteins. It is also unknown if other members of the LCGT-producing clostridia, including Paeniclostridium sordellii (previously Clostridium sordellii), use a similar toxin-release mechanism. Here, we confirm that each of the LCGT-producing clostridia encode functional holin-like proteins in close proximity to the toxin genes. To characterise the respective roles of these holin-like proteins in the release of the LCGTs, P. sordellii and its lethal toxin, TcsL, were used as a model. Construction and analysis of mutants of the P. sordellii tcsE (holin-like) gene demonstrated that TcsE plays a significant role in TcsL release. Proteomic analysis of the secretome from the tcsE mutant confirmed that TcsE is required for efficient TcsL secretion. Unexpectedly, comparative sample analysis showed that TcsL was the only protein significantly altered in its release, suggesting that this holin-like protein has specifically evolved to function in the release of this important virulence factor. This specificity has, to our knowledge, not been previously shown and suggests that this protein may function as part of a specific mechanism for the release of all LCGTs.
Different Algicidal Modes of the Two Bacteria Aeromonas bestiarum HYD0802-MK36 and Pseudomonas syringae KACC10292T against Harmful Cyanobacteria Microcystis aeruginosa
Authors: Park Bum Soo , Park Chong-Sung , Shin Yuna , Yoon Sungae , Han Myung-Soo , Kang Yoon-Ho
Published: February 2022

Blooms of harmful cyanobacteria Microcystis aeruginosa lead to an adverse effect on freshwater ecosystems, and thus extensive studies on the control of this cyanobacteria’s blooms have been conducted. Throughout this study, we have found that the two bacteria Aeromonas bestiarum HYD0802-MK36 and Pseudomonas syringae KACC10292T are capable of killing M. aeruginosa. Interestingly, these two bacteria showed different algicidal modes. Based on an algicidal range test using 15 algal species (target and non-target species), HYD0802-MK36 specifically attacked only target cyanobacteria M. aeruginosa, whereas the algicidal activity of KACC10292T appeared in a relatively broad algicidal range. HYD0802-MK36, as a direct attacker, killed M. aeruginosa cells when direct cell (bacterium)-to-cell (cyanobacteria) contact happens. KACC10292T, as an indirect attacker, released algicidal substance which is located in cytoplasm. Interestingly, algicidal activity of KACC10292T was enhanced according to co-cultivation with the host cyanobacteria, suggesting that quantity of algicidal substance released from this bacterium might be increased via interaction with the host cyanobacteria.
Dynamics of HIV-1 Gag Processing as Revealed by Fluorescence Lifetime Imaging Microscopy and Single Virus Tracking
Authors: Qian Chen , Flemming Annica , Müller Barbara , Lamb Don C.
Published: February 2022

The viral polyprotein Gag plays a central role for HIV-1 assembly, release and maturation. Proteolytic processing of Gag by the viral protease is essential for the structural rearrangements that mark the transition from immature to mature, infectious viruses. The timing and kinetics of Gag processing are not fully understood. Here, fluorescence lifetime imaging microscopy and single virus tracking are used to follow Gag processing in nascent HIV-1 particles in situ. Using a Gag polyprotein labelled internally with eCFP, we show that proteolytic release of the fluorophore from Gag is accompanied by an increase in its fluorescence lifetime. By tracking nascent virus particles in situ and analyzing the intensity and fluorescence lifetime of individual traces, we detect proteolytic cleavage of eCFP from Gag in a subset (6.5%) of viral particles. This suggests that for the majority of VLPs, Gag processing occurs with a delay after particle assembly.
PhageLeads: Rapid Assessment of Phage Therapeutic Suitability Using an Ensemble Machine Learning Approach
Authors: Yukgehnaish Kumarasan , Rajandas Heera , Parimannan Sivachandran , Manickam Ravichandran , Marimuthu Kasi , Petersen Bent , Clokie Martha R. J. , Millard Andrew , Sicheritz-Pontén Thomas
Published: February 2022

The characterization of therapeutic phage genomes plays a crucial role in the success rate of phage therapies. There are three checkpoints that need to be examined for the selection of phage candidates, namely, the presence of temperate markers, antimicrobial resistance (AMR) genes, and virulence genes. However, currently, no single-step tools are available for this purpose. Hence, we have developed a tool capable of checking all three conditions required for the selection of suitable therapeutic phage candidates. This tool consists of an ensemble of machine-learning-based predictors for determining the presence of temperate markers (integrase, Cro/CI repressor, immunity repressor, DNA partitioning protein A, and antirepressor) along with the integration of the ABRicate tool to determine the presence of antibiotic resistance genes and virulence genes. Using the biological features of the temperate markers, we were able to predict the presence of the temperate markers with high MCC scores (>0.70), corresponding to the lifestyle of the phages with an accuracy of 96.5%. Additionally, the screening of 183 lytic phage genomes revealed that six phages were found to contain AMR or virulence genes, showing that not all lytic phages are suitable to be used for therapy. The suite of predictors, PhageLeads, along with the integrated ABRicate tool, can be accessed online for in silico selection of suitable therapeutic phage candidates from single genome or metagenomic contigs.
T Cell Response following Anti-COVID-19 BNT162b2 Vaccination Is Maintained against the SARS-CoV-2 Omicron B.1.1.529 Variant of Concern
Authors: Cohen Hila , Rotem Shahar , Elia Uri , Bilinsky Gal , Levy Itzchak , Chitlaru Theodor , Bar-Haim Erez
Published: February 2022

The progression of the COVID-19 pandemic has led to the emergence of variants of concern (VOC), which may compromise the efficacy of the currently administered vaccines. Antigenic drift can potentially bring about reduced protective T cell immunity and, consequently, more severe disease manifestations. To assess this possibility, the T cell responses to the wild-type Wuhan-1 SARS-CoV-2 ancestral spike protein and the Omicron B.1.1.529 spike protein were compared. Accordingly, peripheral blood mononuclear cells (PBMC) were collected from eight healthy volunteers 4–5 months following a third vaccination with BNT162b2, and stimulated with overlapping peptide libraries representing the spike of either the ancestral or the Omicron SARS-CoV-2 virus variants. Quantification of the specific T cells was carried out by a fluorescent ELISPOT assay, monitoring cells secreting interferon-gamma (IFNg), interleukin-10 (IL-10) and interleukin-4 (IL-4). For all the examined individuals, comparable levels of reactivity to both forms of spike protein were determined. In addition, a dominant Th1 response was observed, manifested mainly by IFNg-secreting cells and only limited numbers of IL-10- and IL-4-secreting cells. The data demonstrate stable T cell activity in response to the emerging Omicron variant in the tested individuals; therefore, the protective immunity to the variant following BNT162b2 vaccination is not significantly affected.
Structure-Based Discovery of N-Sulfonylpiperidine-3-Carboxamides as Novel Capsid Assembly Modulators for Potent Inhibition of HBV Replication
Authors: Yang Yang , Yan Yu , Yin Jiaxin , Hu Jie , Cai Xuefei , Hu Jieli , Xia Jie , Wang Kai , Tang Ni , Huang Luyi
Published: February 2022

As a key element during HBV replication, a nucleocapsid is considered a promising target for the treatment of chronic hepatitis B. The present study aimed to identify small molecules as novel capsid assembly modulators with antiviral activity. Structure-based virtual screening of an integrated compound library led to the identification of several types of HBV inhibitors. Among these inhibitors, N-sulfonylpiperidine-3-carboxamides (SPCs) potently reduced the amount of secreted HBV DNA. Through structure–activity relationship studies, we identified an SPC derivative, namely, C-39, which exhibited the highest antiviral activity without causing cytotoxicity. Mechanism studies showed that C-39 dose-dependently inhibited the formation of HBV capsid, synthesis of cccDNA, e antigen (HBeAg), viral pregenomic RNA (pgRNA), and HBV DNA levels, thereby restraining HBV replication. In summary, SPCs represent a new class of capsid assembly modulators. Further optimization of SPCs is expected to obtain new antiviral drugs against HBV infection.
NSG-Mice Reveal the Importance of a Functional Innate and Adaptive Immune Response to Overcome RVFV Infection
Authors: Michaely Lukas Mathias , Rissmann Melanie , Keller Markus , König Rebecca , von Arnim Felicitas , Eiden Martin , Rohn Karl , Baumgärtner Wolfgang , Groschup Martin , Ulrich Reiner
Published: February 2022

Rift Valley fever (RVF) is a zoonotic disease caused by RVF Phlebovirus (RVFV). The RVFV MP-12 vaccine strain is known to exhibit residual virulence in the case of a deficient interferon type 1 response. The hypothesis of this study is that virus replication and severity of lesions induced by the MP-12 strain in immunocompromised mice depend on the specific function of the disturbed pathway. Therefore, 10 strains of mice with deficient innate immunity (B6-IFNARtmAgt, C.129S7(B6)-Ifngtm1Ts/J, B6-TLR3tm1Flv, B6-TLR7tm1Aki, NOD/ShiLtJ), helper T-cell- (CD4tm1Mak), cytotoxic T-cell- (CD8atm1Mak), B-cell- (Igh-Jtm1DhuN?+N2), combined T- and B-cell- (NU/J) and combined T-, B-, natural killer (NK) cell- and macrophage-mediated immunity (NOD.Cg-PrkdcscidIl2rgtm1WjI/SzJ (NSG) mice) were subcutaneously infected with RVFV MP-12. B6-IFNARtmAgt mice were the only strain to develop fatal disease due to RVFV-induced severe hepatocellular necrosis and apoptosis. Notably, no clinical disease and only mild multifocal hepatocellular necrosis and apoptosis were observed in NSG mice, while immunohistochemistry detected the RVFV antigen in the liver and the brain. No or low virus expression and no lesions were observed in the other mouse strains. Conclusively, the interferon type 1 response is essential for early control of RVFV replication and disease, whereas functional NK cells, macrophages and lymphocytes are essential for virus clearance.
Wastewater Treatment Using Novel Magnetic Nanosponges
Authors: Chhetri Tilak , Cunningham Gary , Suresh Dhananjay , Shanks Bruce , Kannan Raghuraman , Upendran Anandhi , Afrasiabi Zahra
Published: February 2022

Modern agricultural activities and concentrated animal feeding operations (CAFOs) are two of the major sources of groundwater contamination that affect the quality of drinking water. Conventional water quality improvement methods include direct filtration, coagulation/settling treatment techniques, membrane-based systems, and absorption-based systems. However, to date, there are no efficient and cost-effective processes available for water treatment. This study developed an innovative nanotechnology-based technique to improve groundwater quality. Magnetic nanosponges (MNSs) were synthesized and characterized using two different magnetic nanoparticles along with polymeric coagulants. The efficiency of MNSs in removing pollutants in wastewater collected from local diary and swine CAFO lagoons was investigated. Standard water quality evaluation parameters, such as the total organic content (TOC), turbidity, total suspended solids (TSS), and biological oxygen demand (BOD), were measured prior to and after treatment with MNSs. The results demonstrate the potential of MNSs to improve the quality of groundwater and support the development of a cost-effective best management practice (BMP) that also employs traditional coagulants at CAFOs and other wastewater treatment plants.
Insights into Shallow Freshwater Lakes Hydrology in the Yangtze Floodplain from Stable Water Isotope Tracers
Authors: Li Jing , Song Fan , Bao Zhicheng , Fan Hongxiang , Wu Huawu
Published: February 2022

Stable isotopes of lake waters are widely used to identify the relative importance of hydrological processes on the lake water balance across the ungauged landscape via the coupled-isotope tracer model. The isotopic compositions of twenty shallow freshwater lakes across the mid-lower reaches of Yangtze floodplain (MLY) were investigated in January and May of 2018. The lake-specific input water (δI) and evaporation-to-inflow (E/I) ratios were estimated to explore the specific lake hydrology across the MLY. Results showed that distinct isotopic enrichment trends in May compared with those in January, which was indicative of stronger evaporation in May. The δ18OI values of specific lakes exhibited large variability across the MLY, which may be related to the watershed properties, such as watershed area and elevation, and rainfall. The estimated E/I ratios of lakes across the MLY were below 1, which suggested that these lakes (code 1–15) are flood-dominated in the middle reaches of Yangtze River where lakes are susceptible to Three Gorges Dams regulations. By contrast, the relatively lower variability of lake E/I ratios were observed from the Yangtze River Delta (code 17–20) because these lakes with developed river network systems are highly exchanged by artificial regulation. Our investigation of lake types and corresponding isotopic evolution patterns are likely typical of other floodplain landscapes and their identification could be used to better predict hydrological responses to ongoing climate change and artificial regulations by dams.
Perancangan Ulang Tata Letak Pada Penggilingan Jagung dengan Metode BLOCPLAN
Authors: Ginting Alman rizky mulianta
Published: February 2022

Tata letak fasilitas adalah fondasi utama dalam industri sebagai perencanaan dan penghubung sirkulasi antara suatu komponen dengan komponen lainnya untuk mendapatkan hubungan yang paling efektif dan efisien antara operator, peralatan, dan proses transformasi material dari penerimaan hingga pengiriman produk jadi. Bentuk tata letak pada gudang penggilingan jagung di desa Kuta Bangun Kec. Tiga Binanga Kab. Karo memiliki kendala dalam proses produksinya sehingga waktu produksi melambat. Penelitian ini dimaksudkan untuk memberikan usulan dan perbaikan kepada pemilik UMKM Jagung agar waktu produksi bisa maksimal. Metode yang digunakan adalah metode Blocplan dan menghasilkan nilai tata letak alternatif yang lebih baik dari tata letak awal gudangyaitu score naik menjadi 0.79-1, sehingga harapan akan memaksimalkan waktu produksi pada mesin penggilingan jagung.
Alterações secundárias no covid-19: uma revisão bibliográfica
Authors: Neri Lima Katriele , Ferreira Cavalcante Souza Aline , Rodrigues Camargo Ana Paula , Pereira Cardoso de Sá Diogo
Published: February 2022

Introdução. O surto da nova doença de coronavírus (COVID-19) na China se espalhou pelo mundo, tornando-se uma emergência de grande preocupação internacional. O novo coronavírus pertence às espécies β dos coronavírus, que são transmitidos principalmente através de gotículas respiratórias. Podendo os sintomas da infecção envolver vários sistemas, incluindo respiratório, gastrointestinal, musculoesquelético e neurológico. Objetivo. Relatar a percepção de alterações secundárias de pacientes com infecção por SARS-CoV-2 em aspectos neurológicos, cognitivos e funcionais. Método. Trata-se de uma revisão bibliográfica, com busca nas bases de dados PubMed e Science Direct, entre o período de abril de 2020 e maio de 2021. Resultados. A presença dos distúrbios gustativos e olfativos se apresentaram em 5 dos estudos examinados, além de outros sintomas mais comuns como a cefaleia e tontura. Sobre a Síndrome de Guillain-Barré (SGB), quatro dos estudos analisados apresentaram casos de pacientes com diagnóstico de SGB e SARS-CoV-2, mostrando uma possível associação entre as patologias, assim como no acidente vascular cerebral. Conclusão. As manifestações neurológicas apresentaram ocorrência frequente no curso da doença. Com grande parte destas alterações acontecendo em estágios iniciais da infecção, ocorrendo ou não em conjunto aos sintomas típicos da infecção. Podendo até mesmo serem as únicas manifestações da infecção, bem como, serem as responsáveis por maiores complicações no quadro clínico dos pacientes.
ON THE QUESTION OF REDUCED MASS ARTICLES TECHNOLOGICAL EFFECTIVENESS IN AVIATION AND ROCKET-SPACE EQUIPMENT ACCESSED WITH DEGENERATIVE DESIGN
Authors: Boldyrev Alexander , Levin Dmitriy , Ryabinina Olga , Boldyrev Aleksandr
Published: February 2022

The paper discusses the features of the design of structures with the use of generative design; the analysis of the software was carried out, taking into account the various industrial man-ufacturability of the design results; formulated technological recommendations for the blank production, as well as for the following ma-chining; for fixing workpieces of complex shape on the machine, it is proposed to use tooling with the use of magnetic fluids.
EFFICIENCY OF APPLICATION OF GRANULATED MEDIA FROM NATURAL MATERIALS FOR VIBRATION DECORATION OF PARTS OF RADIO ELECTRONIC EQUIPMENT
Authors: Tamarkin Mikhail , Kolganova Yelena , Lebedev Valerii , Shishkina Antonina
Published: February 2022

The article discusses the features of the granu-lometric characteristics of processing media made from natural materials and their influence on the quality of finishing processing of parts of electronic equipment under vibration processing conditions. It is shown that the presence of wedge-shaped tops, different in size and angular position relative to each other, makes it possible to consider the granule as a tool that performs cutting and has access to various surfaces of the workpiece. Recommendations for the selection of the granulometric characteristics of the pro-cessing media are offered.
IMPROVING THE EFFICIENCY OF THE FOREST TRADING BY USING A RECUPERATIVE PNEUMATIC HYDRAULIC COUPLING DEVICE
Authors: Posmetev Valerii , Nikonov Vadim , Siz'min Igor'
Published: February 2022

The necessity of using timber trucks with trailers in order to increase the productivity of hauling timber has been substantiated. The advantages of using timber trucks with trailers over single timber trucks are described. The analysis of scientific works of foreign authors in the field of increasing the efficiency of timber trucks with trailers is carried out. An assessment was made of the operation of timber trucks with trailers in the existing conditions for the transportation of timber in the Russian Federation. The negative factors limiting the efficiency of timber-carrying road trains are revealed. The most significant factor, which can lead to dangerous consequences, is highlighted, which consists in the emergence of critically large forces in the coupling device of a timber road train during sudden braking. Changes in the braking forces of the bridges of a logging vehicle with a trailer during sharp braking, as well as three possible cases of interaction when braking a logging vehicle with a trailer, are considered. A promising design of a recuperative pneumohydraulic coupling device for a timber truck with a trailer has been proposed.
Features of the Clinical Course of Fungal Maxillary Sinusitis
Authors: Кока К.Е. , Меркулова Е.П. , Саврасова Н.А. , Кобахидзе А.Г. , Колесникова С.Н.
Published: February 2022

Введение. Статья посвящена анализу особенностей клинических и рентгенологических проявлений грибкового поражения верхнечелюстных пазух по данным историй болезни 27 пациентов оториноларингологического отделения УЗ «11-я ГКБ» с различными формами грибкового риносинусита. Цель. Повышение эффективности диагностики и лечения пациентов с грибковым риносинуситом на основании анализа особенностей клинических, рентгенологических и лабораторных данных. Материалы и методы. Проанализированы результаты диагностических мероприятий 27 пациентов с различными формами грибкового риносинусита. Результаты. Установлены малосимптомность заболевания, агрессивное поражение слизистой оболочки пазухи, вовлечение других околоносовых пазух, закрытый остеомеатальный комплекс, разрушение латеральной стенки полости носа. Выводы. Пациенты с подозрением на грибковое поражение верхнечелюстной пазухи требуют междисциплинарного подхода с анализом рентгенологических исследований, осмотром челюстно-лицевого хирурга и врача-стоматолога для определения последовательности и объемов хирургического лечения.

Introduction. The article is devoted to the analysis of the features of clinical and radiological manifestations of fungal infections of the maxillary sinuses. Purpose. Improving the efficiency of diagnostics and treatment of patients with fungal rhinosinusitis based on the analysis of clinical, radiological and laboratory data. Materials and methods. There were analyzed the results of diagnostic procedures in 27 patients with various forms of fungal rhinosinusitis. Results. The following was found: low-symptom disease, aggressive damage to the sinus mucosa, involvement of other paranasal sinuses, closed osteomeatal complex, destruction of the lateral wall of the nasal cavity. Conclusions. Patients with suspected fungal infection of the maxillary sinus require interdisciplinary approach with the analysis of X-ray examinations, examination of the maxillofacial surgeon and dentist to determine the sequence and scope of surgical treatment.
Modern Antidepressants in the Treatment of Mental Disorders in Post-COVID Conditions
Authors: Кирпиченко А.А.
Published: February 2022

В статье приведены данные о психических нарушениях при коронавирусной инфекции и постковидном синдроме (U09.9). Сделан литературный обзор эффективности антидепрессантов различных групп в лечении коронавирусной инфекции. Описаны особенности мультимодального антидепрессанта вортиоксетин как в рамках коронавирусной инфекции, так и при изолированных расстройствах депрессивного спектра. Сделаны выводы о потенциале антидепрессантов в терапии депрессий при инфекции COVID-19.

The article provides data on mental disorders in coronavirus infection and COVID syndrome (U09.9). A literature review about the effectiveness of antidepressants of various groups in the treatment of coronavirus infection was made. The features of the multimodal antidepressant vortioxetine are described both within the framework of coronavirus infection and in isolated disorders of the depressive spectrum. The conclusions are drawn about the potential of antidepressants in the treatment of depression in COVID-19 infection.
Primary Hyperaldosteronism as a Cause of Refractory Arterial Hypertension. A Clinical Case
Authors: Казакова М.И. , Галицкая С.С.
Published: February 2022

В последние годы достигнут значительный прогресс в понимании патогенеза первичного гиперальдостеронизма (ПГА), расширены показания для проведения скрининга, разработаны алгоритмы для медикаментозного и хирургического лечения. У пациентов с ПГА более высокий риск развития инфаркта миокарда, кардиального фиброза, диастолической дисфункции, гипертрофии миокарда левого желудочка, дилатации полостей сердца и возникновения аритмий по сравнению с пациентами с эссенциальной артериальной гипертензией. Риск внезапной сердечной смертности у этих пациентов увеличивается в 10-12 раз. Своевременно поставленный диагноз ПГА позволяет предотвратить развитие осложнений, улучшить качество жизни и снизить инвалидизацию пациентов. В статье представлен клинический случай диагностики и лечения первичного гиперальдостеронизма как наиболее частой причины вторичной артериальной гипертензии. Стертая клиническая картина в дебюте заболевания и отсутствие гипокалиемии маскируют первичный гиперальдостеронизм под эссенциальную гипертензию и приводят к позднему выявлению заболевания.

In recent years, significant progress has been made in understanding the pathogenesis of primary hyperaldosteronism (PHA). The indications for screening have been expanded; the algorithms for drug and surgical treatment have been developed. Patients with PHA have a higher risk of development of myocardial infarction, cardiac fibrosis, diastolic dysfunction, left ventricular hypertrophy, dilation of the heart cavities, and occurrence of arrhythmias if compared with patients with essential arterial hypertension. The risk of sudden cardiac death in these patients increases by 10-12 times. A timely diagnosis of PHA can prevent the development of complications, improve the quality of life, and reduce the disability of patients. The article presents a clinical case of diagnosis and treatment of primary hyperaldosteronism as the most common cause of secondary arterial hypertension. A blurred clinical picture at the onset of the disease and the absence of hypokalemia mask primary hyperaldosteronism as essential hypertension and lead to late detection of disease.
Tooth Color Formation Under the Influence of the Microcirculatory Bed of Pulp
Authors: Новак Н.В.
Published: February 2022

Приведены результаты изучения влияния красного цвета пульпы на формирование оттенков зуба пациентов разных возрастных групп. Показано, что на процесс отражения света от пульпы и формирование цвета зуба влияют несколько факторов: степень минерализации эмали и дентина; выраженность деградации пульпы и размеры полости зуба; толщина твердых тканей. Оттенки цвета зуба определяются совокупностью его оптических характеристик, включающих отражение, пропускание, рассеивание света и флуоресцентные свойства. Свет, отраженный от пульпы, влияет на формирование оттенков цвета зуба, о чем свидетельствует смещение значений коэффициентов диффузного отражения зубов при имитации пульпы в длинноволновую область спектра, соответствующую красно-коричневым оттенкам. Такие изменения наиболее характерны для зубов пациентов среднего (26–44 лет) и старшего (45–60 лет) возраста. Для этих возрастных групп коэффициенты диффузного отражения имеют обратную линейную корреляционную связь с размерами полости и вестибулярной стенки зуба. Результаты проведенного исследования по изучению влияния пульпы на параметры отражения света от поверхности зубов пациентов разного возраста имеют не только научную новизну, но и практическую значимость. На их основе разработан способ изготовления цветокорригирующего винира с воссозданием цвета пульпы.

Results of studying of influence of red color of a pulp on formation of shades of tooth of patients of different age groups are given in article. It is shown that process of reflection of light from a pulp and formation of color of tooth is influenced by several factors: degree of a mineralization of enamel and dentine; expressiveness of degradation of a pulp and sizes of a cavity of tooth; thickness of solid fabrics. Shades of color of tooth are defined by set of his optical characteristics including reflection, transmission, dispersion of light and fluorescent properties. Light reflected from a pulp influences formation of shades of color of tooth what the shift of values of coefficients of diffusion reflection of teeth at imitation of a pulp to the long-wave area of a range corresponding to red-brown shades testifies to. Such changes are most characteristic of teeth of patients of an average (26–44 years) and the senior (45–60 years) of age. For these age groups coefficients of diffusion reflection have the return linear correlation communication with the sizes of a cavity and a vestibular wall of tooth. Results of the conducted research on studying of influence of a pulp on parameters of reflection of light from the surface of teeth of patients of different age have not only scientific novelty, but also the practical importance. On their basis the way of production of a correcting color veneer with reconstruction of color of a pulp is developed.
Nehir Tipi Hidroelektrik Santrallerinde Rampa Olayları Türkiye Örneği
Authors: KARADÖL İsrafil , ŞEKKELİ Mustafa
Published: February 2022

Yenilenebilir enerji kaynaklarının tahmin edilemeyen üretim yapısından dolayı bu kaynakların geleneksel şebeke sistemlerine entegrasyonları, şebeke esnekliği ve güvenliği açısından birçok soruna neden olmaktadır. Bu çalışmada, yenilenebilir enerji kaynaklarının üretim değişiminin yönünü, büyüklüğünü, zamanını ve frekansını öngörebilmek amacıyla Türkiye Nehir tipi Hidroelektrik santral (NHES) üretimlerinin rampa olayları incelenmiştir. Bu amaçla, ilk olarak Türkiye’de kurulu 483 adet NHES’in 2017 ve 2018 yıllarına ait reel üretimleri elde edilmiştir. Elde edilen verilerin aylık rampa olaylarını araştırmak için NHES üretimleri, aylık zaman dilimlerine bölünmüştür. Aylık NHES üretimlerinin 1, 3, 6 ve 9 saatlik periyotlardaki rampa olayları incelenmiştir. 1 saatlik periyottaki NHES üretim rampalarının istatistiksel özelliklerini değerlendirdiğimizde maksimum ve minimum rampa olaylarının oluşum zamanlarının tahmin edilemeyeceği sonucuna ulaşılmıştır. Fakat aynı zamansal periyottaki rampaların ortalamalarını ve standart sapmalarını incelediğimizde ise en fazla rampa olaylarının kış aylarında (Aralık, Ocak, Şubat) gerçekleştiği sonucuna ulaşılmıştır. Elde edilen sonuçlara göre rampaların büyüklüğüne, frekansına ve zamanına göre önlemler alınması durumunda yenilenebilir enerji kaynaklarının geleneksel şebeke sistemine entegrasyon sorunlarının minimize edilebileceği ön görülmektedir.
DEVELOPING BEST PRACTICE IN MICROPALAEONTOLOGY: EXAMPLES FROM THE MID-CRETACEOUS OF THE ZAGROS MOUNTAINS
Authors: SCHLAGINTWEIT FELIX , SIMMONS MIKE
Published: February 2022

Micropalaeontological studies can provide important information on how strata correlate, age calibration, palaeoenvironmental determination, palaeobiology, evolutionary relationships of the taxa being studied, palaeogeography, and the recognition of global or regional geological events in a local succession. However, the value of micropalaeontological studies is constrained by the accuracy with which taxa are identified, the accuracy of their age interpretation, and the use of up-to-date taxonomic concepts, supported by modern research literature. Best practice implies attention to these and other details, which we illustrate with reference to published research on larger benthic foraminifera (especially orbitolinids) from the mid-Cretaceous succession of the Zagros Mountains in the Middle East. It is demonstrated that whilst there are many excellent studies, a significant number could offer more value if they were to use precise, modern taxonomic concepts applied to well-illustrated and documented unequivocal material. Poorly founded age assignments and misidentifications can lead to confusion on assessment of true stratigraphic ranges and evolutionary patterns. Moreover, they can lead to miscorrelation and erroneous modelling of the subsurface in a hydrocarbon-rich region. Integrated studies of larger benthic foraminifera with other age-diagnostic fossil groups or chemostratigraphic methods would further enhance their utility. These recommendations are applicable to micropalaeontological studies on microfossils of any type and age, from any part of the world, but we hope will promote additional rigour in studies on the micropalaeontology of the Mesozoic and Cenozoic succession of the Zagros that still have much to impart.
Determinando el pronóstico del paciente Gran Quemado: Correlación del Índice de Garcés con el Abbreviated Burn Severity Index (ABSI)
Authors: Macchiavello Macho Roberto Ariel , Paulos Parot María Angélica , Soto Diez Carolina , Calcagno Lüer Manuel , Barril Merino Carlos
Published: February 2022

Introducción: Existen distintos scores pronósticos para determinar probabilidad de muerte en pacientes quemados. El Índice de Garcés (IG) utilizado en Chile, no es aceptado mundialmente. Decidimos evaluar la correlación entre IG y Abbreviated Burn Severity Index (ABSI), de uso generalizado. Métodos: Estudio descriptivo analítico transversal de pacientes quemados subidos a la plataforma online  “Registro Nacional de Quemados” y luego ingresados a nuestro centro entre Julio 2017 y Julio 2018. Se calculó coeficiente de correlación de Pearson entre IG y ABSI. Se normalizan ambas variables para hacerlas comparables y se calculó concordancia entre estas con coeficiente de correlación de Lin. Con análisis de regresión logística se calculó probabilidad de fallecer asociada para ambas variables y se compararon áreas de las curvas ROC de ambos scores. Resultados: De 141 pacientes, 15 fallecieron durante hospitalización, con medias de IG de 104 ± 49 puntos y ABSI 7 ± 2. El coeficiente de correlación de Pearson entre IG y ABSI demostró ser muy alto con un valor de 0,928. El coeficiente de correlación de Lin entregó concordancia moderada con un valor de 0,93. Al comprobar cuál de las dos puntuaciones predice mejor la probabilidad de muerte mediante análisis de sensibilidad y especificidad, la curva ROC cubre más área en IG (0,82 vs 0,83), sin ser estadísticamente significativo. Conclusiones: Ambos índices, IG y ABSI, son muy similares para predecir la probabilidad de muerte, por lo cual son equiparables a la hora de compartir resultados de estudios científicos.
Tratamiento quirúrgico de las Ulceras por presión sacras con colgajo Miocutáneo de Gluteus Maximus por deslizamiento en V-Y: Técnica quirúrgica.
Authors: Calderón Wilfredo , Cabello P. Rodrigo , Lombardi Juan Jose , Camacho Martino Juan Pablo , Obaid Miguel , Subiabre Rodrigo
Published: February 2022

Introducción: La úlcera por presión más frecuente es la sacra. Si compromete el hueso puede provocar osteomielitis por lo que requiere aseo quirúrgico y colgajo miocutáneo de Gluteus Maximus por deslizamiento en V-Y.Material y método: En el servicio de cirugía plástica del hospital del Salvador entre 2011 y 2020 se han operado 82 pacientes con ulceras sacras grado 4 que requirieron cobertura con colgajo miocutáneo de gluteus maximus en V-Y. De ellas se analizaron los últimos 37 pacientes. Resultados: De los 37 pacientes, 12 fueron mujeres, 25 hombres, 17 parapléjicos, 12 tetrapléjicos, y 8 deambulaban. 6 pacientes presentaron Covid-19. 24 fueron bilaterales y 13 unilaterales. Los colgajos cicatrizaron bien en 30 pacientes. Las complicaciones fueron de 16% consistente en 2 hematomas, 2 dehiscencias, 2 celulitis, y 1 seroma, todas resueltas sin problemas. Seguimiento de entre 3 y 6 meses.Discusión: El tratamiento quirúrgico con colgajo miocutáneo de gluteus maximus en V-Y, aparte de aportar volumen para ocluir la úlcera, aporta irrigación excelente con oxígeno, nutrientes y antibióticos que aseguran una óptima cicatrización. Dependiendo del diámetro de la úlcera el colgajo puede ser uni o bilateral. Dado lo complejo del tratamiento, en general, el porcentaje de complicaciones de 16% se considera bajo. Conclusión; El tratamiento quirúrgico de las úlceras por presión sacras con colgajos miocutáneos deslizantes de Gluteus Maximus ha sido éxitoso con buenos resultados quirúrgicos con buen flujo sanguíneo y buena evolución.
Tratamiento quirúrgico de las Ulceras por radionecrosis con colgajos musculocutáneos y fasciocutáneos .
Authors: Calderón Wilfredo Luis , Mora Godoy Roberto , Obaid García Miguel , Camacho Martino Juan Pablo , Guler Gonzalez Kenneth , Lombardi Azócar Juan José , Subiabre Rodrigo
Published: February 2022

Objetivo: Presentar el tratamiento quirúrgico de las Ulceras por radionecrosis mediante colgajos Miocutáneos y Fasciocutáneos pediculados y microquirúrgicos.Introducción: La Ulcera  con radionecrosis debe ser resecada ampliamente y reparada con colgajos miocutáneos  y  fasciocutáneosMaterial y Método: La casuística es de  31 pacientes portadores de ulceras por radionecrosis resueltas con colgajos   miocutáneos y  fasciocutáneos. Ellos han sido pediculados y  microquirúrgicos. Las edades fluctuaron entre 30 y 75 años operados entre el 2000 y el 2019.Resultados: Se realizaron 19 colgajos musculares o miocutáneos y 12 fasciocutáneos en diferentes zonas del organismo. Los colgajos correspondieron a : temporal, latissimus dorsi de pediculo central y en reversa , latissimus dorsi microquirúrgicos, recto abdominal, escapular microquirúrgico, para escapular, gracilis ,gastrocnemius, rectus femoris, cubital microquirúrgico, fasciocutaneos: cone flap y de rotación local. Las complicaciones fueron dehiscencia de herida operatoria suturada  y celulitis tratada con antibióticos. No hubo necrosis completa de los colgajos. El seguimiento fue de 3 a 6 meses.Discusión: En ésta  serie hemos utilizados los colgajos  músculo cutáneos de preferencia, los fascio cutáneos los hemos reservados para aquellos casos en los que por razones anatómicas, de localización de las úlceras, era más adecuado usar estos últimos, como en las lesiones planas o poco profundas.Generalmente los colgajos fueron pediculados  y en determinados casos, cuando el tejido vecino de reparación no estaba disponible, realizamos colgajos con microcirugía.Conclusión: El tratamiento de las úlceras por radionecrosis es efectivo cuando se realiza desbridamiento exhaustivo con cobertura inmediata con colgajos musculares o músculocutáneos y  fasciocutáneos. Fueron  colgajos pediculados y  microquirúrgicos.
Pengaruh Korean Wave dan Brand Ambassador pada Pengambilan Keputusan Konsumen
Authors: Rahmadani Amarilis , Anggarini Yunita
Published: February 2022

This study aims to analyze the influence of the Korean wave and brand ambassadors on consumer purchasing decisions. This research is a quantitative study using a population of consumers of Nacific cosmetic products from South Korea. By using purposive sampling technique, a sample of 100 respondents was tested in this study. The analytical method used is binary logistic regression analysis. The results showed that the decision to purchase Korean cosmetic products was strongly influenced by the Korean wave, and vice versa was not influenced by the brand ambassador. This study shows that Korean culture has a fairly strong influence on Indonesian consumers' decisions to buy cosmetic products. Meanwhile, Korean influencers have no influence on purchasing decisions, which factors need to be studied. This study adds a reference to behavioral research related to the effects of cultural change in Indonesia, especially the influence of Korean culture.
Arabic Teacher Creativity Towards The Use Of Information Technology In Distance Learning
Authors: Sabella Nabella , Hasan Hasan
Published: February 2022

The main problem in this study, along with the COVID-19 pandemic, which has plagued Indonesia for more than a year, has caused various problems and impacted various aspects of life, especially in education. To reduce the spread of COVID-19, the government enforces distance learning, which also impacts learning Arabic and requires teachers to develop creativity in learning. Using a qualitative field research method, this study aims to determine the creativity of Arabic language teachers in utilizing information technology for distance learning during the covid-19 pandemic. As for some of the media used, such as. Create video content, take advantage of social media, use video conferencing applications such as Zoom and Google Meet, to take advantage of educational website services in the form of Google Classroom and Wordwall games. Based on the results of the analysis conducted by the researchers, this study proved that there are various kinds of teacher creativity in learning Arabic online, such as interactive multimedia, quizzes with google forms, word wall games, and so on. Second, eliminating student learning boredom by developing teacher creativity based on information technology. Third, it is still necessary to conduct information technology-based creativity development training, especially in learning Arabic, because not all Arabic language teachers can develop information technology-based teaching skills. This study proved that there are various kinds of teacher creativity in learning Arabic online, such as interactive multimedia, quizzes with google forms, word wall games. Second, eliminating student learning boredom by developing teacher creativity based on information technology.

Keywords: Creativity, Arabic Teacher, Distance Learning, Information Technology.