bluuebunny/crossref_metadata_2025 huggingface dataset:
Study on the Influence of Stiffness of Beam–Column Connections on the Seismic Behavior of Composite Moment Resisting Frames
Authors: KHEMIS Ahmed , TITOUM Messaoud , MAZOZ Aida , LOUZAI Amar
Published: October 2021

In the design of steel or composite structures, the connections are usually considered infinitely rigid or perfectly pinned. However, the real behavior of these connections is semi-rigid. Consequently, this semi-rigidity can influence the overall behavior of the composite structures, especially the moment-resisting frames. Seismically, the most critical parameter that characterizes the frames behavior is the response factor R. In this context, the research work consists of studying the semi-rigidity effect of the connections on the behavior of the composite frames by evaluating the response modification factor R by using the Pushover method. To accomplish this task, three types of portal frames of 3, 4 and 5 storeys were analyzed for different degrees of connection (beam-column). An easy and practical solution has been proposed to determine the approximate value of the coefficient behavior R for the composite frames with semi-rigid connections.
Monitoring and Management of Geoengineering Repositories of Radioactive Waste
Authors: YEREMEYEV Igor , DYCHKO Alina , KYSELOV Volodymyr , ZAICHENKO Stefan
Published: October 2021

The paper provides the approach to the management of the repositories of radioactive waste, which include monitoring of contaminants migration into environment in case of natural or technogenic accidents which may influence on soil, subsoil waters and repository’ installations structures. The aim of the research is the development of system of estimation of radioactive state of the environment in the area of radioactive repository, based on the cumulative data, the knowledge base, set of rules of production, logical deduction gear and conclusion building gear by means of uncertain and incomplete input data. It is proposed the use of several models for the spectral characteristics of radioactive pollutants migration. The evaluation of possible damages of repository containment is made. The heuristics for the radioactive waste repository expert system are developed. The proposed procedure of quality definition of decision making for the radioactive waste repositories management should take into account the reliability of information about the state of the radioactive repository.
A Review of Lane Detection Based on Semantic Segmentation
Authors: Shi Jiaqi , Zhao Li
Published: October 2021

With the introduction of full convolutional neural product networks, semantic segmentation networks have also been widely used in the field of deep learning. Most lane detection tasks are currently done on the basis of semantic segmentation networks, so the development of semantic segmentation also directly determines the progress of lane detection. Methods: The development of semantic segmentation networks and the performance comparison between different model frames are used to summarize the improvement points as well as the advantages and disadvantages of each approach. Current lane detection network models with good performance based on semantic segmentation networks are described and the performance between the models is compared. Result: The current development of deep learning-based lane detection methods has been very fruitful, with significant improvements in network performance, but they cannot yet be applied in practice. For example, lightweight networks are not stable enough in extracting features, while deep neural networks are too ineffective in real time. Conclusion: Lane detection is of high research value as a key technology for unmanned driving. However, most of the current neural network methods have not been studied from a practical point of view, and there are few methods that use multiple frames as a basis for research. Therefore, in the future how to efficiently use continuous images for lane detection is a key direction to be researched in the future.
Pengaruh Penggunaan Lahan, Sumber Pencemar dan Tipe Vegetasi Riparian terhadap Kualitas Air Sungai Code Daerah Istimewa Yogyakarta
Authors: Njurumay Reksi , Rahardjo Djoko , Kisworo
Published: October 2021

Sebagai salah satu sungai besar di Provinsi Daerah Istimewa Yogyakarta, kualitas air Sungai Code banyak ditentukan oleh pengaruh aktivitas manusia dan kondisi alamiah yang ada disekitarnya. Penelitian ini bertujuan untuk mengetahui hubungan antara tataguna lahan, tipe vegetasi riparian, dan sumber bahan pencemar terhadap kualitas air sungai Code. Metode penelitian yang digunakan adalah purposive sampling. Parameter yang diukur terdiri dari parameter fisik, kimia, dan biologi. Parameter fisik sungai meliputi kedalaman, kekeruhan, kecerahan, kecepatan arus, debit air, suhu, tipe substrat, TSS, dan TDS. Parameter kimia sungai meliputi pH, DO, BOT, nitrat, fosfat, dan amonia. Parameter biologi meliputi vegetasi riparian dengan indeks biotik meliputi kerapatan, indeks kekayaan jenis, dan indeks keanekaragaman jenis. Penggunaan lahan di sungai Code didominasi oleh pembangunan (tanggul,pemukiman), pertanian dan jalan. Aktivitas masyarakat didominasi oleh aktivitas bertani dan penambangan pasir. Jenis sumber pencemar yang dominan adalah limbah rumah tangga.Karakteristik lingkungan di sungai Code adalah berbatu dan berpasir. Ditemukan 36 spesies,25 famili, 23 ordo, 4 kelas, dan 2 divisi. Struktur komunitas vegetasi riparian didominasi oleh famili Poaceae, Asteraceae dan Malvaceae. Penggunaan lahan, pola aktivitas dan sumber pencemar dapat mempengaruhi kualitas air sungai Code (parameter fisik dan kimia). Keberadaan struktur komunitas vegetasi riparian dapat mempengaruhi kualitas air sungai Code khususnya pada parameter BOT dan Nitrat air sungai Code.
Studi Etnobotani Kelapa (Cocos nucifera) di Desa Tambi, Kecamatan Sliyeg, Kabupaten Indramayu
Authors: Solechah Imah , Hayati Ari , Zayadi Hasan
Published: October 2021

Etnobotani adalah studi tentang hubungan antara manusia dan penggunaan tumbuhan secara tradisional. Kelapa (Cocos nucifera) merupakan salah satu tanaman yang memiliki nilai pemanfaatan yang tinggi dalam masyarakat. Berdasarkan survei awal, tanaman kelapa banyak dimanfaatkan sebagai obat, sumber pangan, bahan kerajinan dan lainnya. Penelitian ini bertujuan untuk mengetahui karakteristik, potensi, distribusi dan pemanfaatan tanaman kelapa di Desa Tambi dan Desa Tambi Lor, Kecamatan Sliyeg, Kabupaten Indramayu. Penelitian ini bermanfaat untuk memberikan informasi kepada masyarakat tentang karakteristik dan pemanfaatan tanaman kelapa serta pentingnya konservasi tanaman kelapa. Penelitian ini dilakukan dengan metode deskriptif kualitatif melalui eksplorasi pengamatan langsung di lapangan dengan wawancara menggunakan kuesioner. Hasil penelitian mendapatkan 3 varietas kelapa yang tumbuh di lokasi penelitian yaitu varietas kelapa dalam hijau, kelapa genjah kuning (gading) dan kelapa genjah hijau. Tanaman kelapa di Desa Tambi dan Desa Tambi Lor dimanfaatkan sebagai bahan pangan dan kerajinan sebesar 20%, adat istiadat sebesar 10%, obat 14 %, bahan bakar sebesar 16%, bahan bangunan sebesar 17% dan jamu sebesar 1%. Distribusi tanaman kelapa Desa Tambi ditemukan pada 18 titik, sedangkan pada Desa Tambi Lor ditemukan 22 titik tumbuh tanaman kelapa. Penyebaran tanaman kelapa berdasarkan tata guna lahan Desa Tambi hanya dijumpai pada pekarangan dan tepi sawah, sedangkan di Desa Tambi Lor, tanaman kelapa di jumpai disemua lahan yaitu pekarangan, tepi jalan, dan tepi sawah.
Uji Antibakteri Rhizopus sp. Asal Inokulum Tempe terhadap Vibrio cholerae
Authors: Khikmah Nur , Haloho Apriani
Published: October 2021

Rhizopus sp. merupakan kapang yang digunakan dalam fermentasi tempe. Kapang Rhizopus pada tempe telah dikaji manfaatnya dalam mengurangi kejadian diare pada Escherichia coli dan Salmonella typhidibandingkan pada Vibrio cholerae. Diare kolera yang disebabkan oleh Vibrio cholerae pernah menjadi Kejadian Luar Biasa (KLB) di Indonesia, sehingga bakteri kolera sebagai penyebab penyakit pada penderita diare masih ada. Penelitian ini bertujuan untuk mengetahui kemampuan antibakteri Rhizopus sp asal inokulum tempe terhadap Vibrio cholerae dan mengetahui perbedaan kemampuan antibakteri Rhizopus sp dari beberapa inokulum tempe terhadap Vibrio cholerae. Uji antibakteri Rhizopus sp terhadap Vibrio cholerae dilakukan dengan metode difusi kertas. Isolasi dari inokulum tempe komersial memperoleh dua isolat kapang, yang teridentifikasi Rhizopus sp.IP dan Rhizopus sp. IJ. Hasil uji antibakteri menunjukkan bahwa dua isolat Rhizopussp. tersebut dapat menghambat Vibrio cholerae. dengan kemampuan penghambat kategori sedang dan tidak terdapat perbedaan aktivitas antibakteri Rhizopus sp. IP dan Rhizopus sp. IJ terhadap Vibrio cholerae.
E SE A FUMAÇA JÁ SUBIU PRA CUCA?
Authors: Darós Silveira Karine , Zucchetti Filho Pedro
Published: October 2021

O presente trabalho teve como objetivo fazer uma resenha da canção "A Fumaça Já Subiu Pra Cuca" interpretada por Bezerra da Silva e através dessa resenha apontar como a sabedoria popular nos remete às questões sobre as ciências criminais. Através dessa música, da doutrina processual penal e da jurisprudência nacional foi possível debater sobre a necessidade ou não de apreensão de drogas para possibilitar a lavratuda de auto de prisão em flagrante nos crimes de tráfico de drogas, assim como sobre a necessidade de lauto pericial sobre a qualidade do material apreendido para embasar sentenças penais condenatórias.
O ABOLICIONISMO PENAL E A JUSTIÇA RESTAURATIVA
Authors: Santos Ribeiro Flora Deane , Periandro de Almeida Hirsch Fábio
Published: October 2021

O presente trabalho tem por finalidade primordial a análise daconcretude dos direitos fundamentais e humanos para odesenvolvimento do abolicionismo penal e da justiça restaurativa noBrasil. Para tal parte-se, portanto, da hipótese de que o abolicionismoe a justiça restaurativa são teorias e procedimentos que encontramresistência no Brasil, devido à latente dificuldade na concretização dosdireitos fundamentais e dos direitos humanos no País, notadamente emface do cenário de grave vulneração ao Estado Democrático deDireito. Para tanto, utiliza-se a abordagem qualitativa, tendo comosedimento a técnica do estudo bibliográfico, a fim de analisar aspossíveis contribuições do abolicionismo penal diante da lógicacarcerogênica aqui exercitada e analisa-se, também, a natureza, afinalidade e os instrumentos da justiça restaurativa. Ao final,abordam-se os direitos fundamentais e humanos na perspectiva deeficácia para difusão de práticas abolicionistas e restaurativas
AS CONSEQUÊNCIAS DA ATUAÇÃO DO MAGISTRADO SÉRGIO MORO NO CASO DA DIVULGAÇÃO DAS INTERCEPTAÇÕES TELEFÔNICAS EM MARÇO DE 2016
Authors: Vechi Fernando
Published: October 2021

Este trabalho visa demonstrar a problemática e as consequências davisibilidade dada a um magistrado tomando como estudo de caso apublicidade das interceptações telefônicas em duas edições do JornalNacional em março de 2016. Diante de uma profissão que exigeimparcialidade, dedicação, prudência, celeridade e discernimento, quaisas consequências político-jurídicas daquele que se encontra na posiçãode julgador e para as partes das decisões proferidas por tal agente. Aanálise será desenvolvida a partir de uma investigação envolvendo LuizInácio Lula da Silva e que afeta a figura da ex-presidente DilmaRousseff. Trabalha-se com pesquisa teórico-bibliográfica, utilizandopara tanto o marco teórico proporcionado pela sociologia ecriminologia. A atuação do magistrado violou direitos e princípiosconstitucionais, causando uma grande mancha na imagem dos políticosenvolvidos.
UM ESTUDO SOBRE A VIABILIDADE EPISTEMOLÓGICA DA SÚMULA N. 70 DO TRIBUNAL DE JUSTIÇA DO RIO DE JANEIRO
Authors: Otoni de Melo Robert George , Arieh Bezerra Medina Lucas
Published: October 2021

O objetivo deste artigo é discutir a validade da Súmula n. 70 do Tribunal de Justiça do Estado do Rio de Janeiro e sua relação com a construção da verdade no processo penal. Para tanto, o artigo pretende revisar as contribuições de Susan Haack para compreender a validade da aplicação desta súmula, considerando a possibilidade do predomínio dos depoimentos das autoridades policiais como condão para sustentar a condenação criminal. Por fim, o artigo pretende sugerir um conceito de standard probatório, visando garantir maior governança na persecução penal.
A PROPORCIONALIDADE DA LEI DO ABATE
Authors: Mantuani Matheus
Published: October 2021

O presente artigo visa dissecar criticamente a chamada Lei do Abate (Lei n.º 9614/98), assim conhecida devido à possibilidade de, em seu uso, derrubar-se aeronaves, independentemente destas estarem ou não com homens a bordo. Utilizou-se aqui o método de ponderação à moda alemã através do chamado princípio da proporcionalidade e seus subprincípios. Munido da necessária filtragem constitucional, pôde-se constatar da invalidade da supracitada Lei perante o ordenamento jurídico brasileiro: resta importante a perda de sua eficácia.

 

Palavras-chave: Lei do Abate. Juízo de Proporcionalidade. Fórmula de Radbruch.
EXPANSÃO PUNITIVISTA, CULPABILIDADE E IMPUTAÇÃO PENAL EMPRESARIAL
Authors: Cavalcanti Rodrigo
Published: October 2021

O presente trabalho busca analisar a problemática da política criminal de combate à criminalidade tomando por objeto a análise da culpabilidade da empresa enquanto pessoa jurídica. Ou seja, se dentro da perspectiva doutrinária e jurisprudencial existe a possibilidade de se imputar a uma pessoa jurídica atos próprios cuja consequência seja autônoma à ação humana e que comporte a esta ação ou omissão um grau de culpabilidade inerente e pertencente à esfera do Direito Penal, analisando critérios ligados a chamada expansão do Direito Penal, a imputação objetiva e a aplicação da própria pena e sua finalidade.
NO CÁRCERE CO.M VID.A NÃO SIM
Authors: Alves de Lima Ricardo
Published: October 2021

Poesia, sem resumo.
NECROPOLÍTICA NAS PERIFERIAS
Authors: Bernardino de Souza Silva Isabela Inês , Pereira Paes de Barros Isabela Maria
Published: October 2021

O presente artigo busca analisar os impactos da Tutela Provisória Incidental na Medida Cautelar na Arguição de Descumprimento de Preceito Fundamental 635, que condicionou a realização de operações policiais nas comunidades periféricas da cidade do Rio de Janeiro, durante a pandemia de COVID-19, à necessidade de pedido escrito. Historicamente, é importante frisar que existe uma indiferença governamental na garantia de assistência aos moradores de favelas, que vivem em um estado de calamidade frente às operações policiais cotidianamente realizadas nesses espaços. A metodologia de pesquisa é qualitativa, com investigação jornalística e bibliográfica, por meio da análise de artigos científicos e documentos nacionais e internacionais. O resultado obtido é que, com a decisão do Ministro Edson Fachin, tendo em vista a diminuição de operações em regiões marginalizadas, houve, nos primeiros 15 dias, uma diminuição do número de mortes de habitantes das comunidades e de policiais, que demonstra um êxito momentâneo decisório.
CORONAVÍRUS E CÁRCERE:
Authors: Lustosa Coelho Ramos Raissa , Juliana Teixeira Esteves
Published: October 2021

Em tempos de pandemia, tem havido um silencioso genocídio da população prisional brasileira, que se manifesta por meio do crescente e sistemático número de mortos e infectados por coronavírus entre presos e servidores que trabalham nesses ambientes. No contexto do neoliberalismo, a forma como as pessoas privadas de liberdade são tratadas no espaço público e lidas pela sociedade é consequência direta das dinâmicas de encarceramento e punitivismo enraizadas no seio social, sendo assim, faz-se necessário avaliar o quadro atual dentro de um contexto pré-existente de política e economia. A partir dessa problemática, o presente estudo se propõe a analisar a omissão do Executivo e do próprio Judiciário em providenciar meios para evitar o agravamento do quadro de contaminação por Covid-19 no sistema prisional e socioeducativo, o que pode ser interpretado como uma expressão de necropolítica e violência estatal. Mesmo após recomendações do Conselho Nacional de Justiça, muitos juízes se recusam a reduzir o número de pessoas presas, e as respostas até agora oferecidas para atenuar a situação não foram efetivas.
SELETIVIDADE PENAL
Authors: Amâncio Beatriz , Loureiro Maria Eduarda
Published: October 2021

O trabalho tem por escopo fomentar a reflexão crítica acerca da seletividade penal no sistema de justiça criminal brasileiro, a partir da análise histórica do surgimento das prisões no país, bem como da Teoria do Direito Penal do Inimigo, cunhada por Günther Jakobs, e a prática do Racismo Institucional que culminaram na formação das estruturas da organização punitiva atual. A fim de ilustrar a temática, tratou-se do emblemático caso de Rafael Vieira Braga, jovem pobre e negro condenado duas vezes em processos judiciais contraditórios e parciais, além da música intitulada “Estereótipo” do cantor Rashid, que denuncia a realidade racista e seletiva. Para tanto, toma-se como base a pesquisa bibliográfica, perpassando por livros e artigos científicos e noticiários. Por fim, pretende-se revelar que o sistema de justiça se pauta em um discurso jurídico-penal que determina, com base na cor e na classe social, a quem servirá o cárcere.
Anlotinib-Induced Hypertension: Current Concepts and Future Prospects
Authors: Lv Bing , Chen Jing , Liu Xiao-Liang
Published: October 2021

Background:

Anlotinib is a new tyrosine kinase inhibitor developed in China that targets the receptors
for vascular endothelial growth factor, platelet-derived growth factor, fibroblast growth factor, and stem
cell factor. Therefore, anlotinib inhibits tumor angiogenesis, representing a new therapeutic alternative for lung
cancer. Hypertension is one of its most common adverse effects, leading to discontinuation of the drug and
limited clinical usefulness.

Objective:

The present review aims to summarize the evidence on the prevalence, physiopathology, and management
of anlotinib-induced hypertension, as well as its effect on the cancer prognosis.

Method:

Searches in Medline, Cochrane Central Library, and Embase were performed using the following
terms: anlotinib, adverse effect, hypertension, clinical trial, vascular endothelial growth factor, and anti-angiogenic
drugs. Citations were also identified by checking the reference sections of selected papers.

Results:

Except for a phase I clinical trial with a small sample size (n = 6), almost all the clinical trials on anlotinib
have reported the development of anlotinib-induced hypertension. In these trials, the incidence of hypertension
ranged from 13% to 67.7%, and that of grade 3/4 hypertension ranged from 4.8% to 16%. Alterations in nitric
oxide, endothelin-1, microvascular rarefaction, selective vasoconstrictions, and renal injury have been cited
as potential mechanisms leading to anlotinib-induced hypertension. When needed, treatment may include general
hygienic measures and pharmacotherapy in some cases.

Conclusions:

To effectively manage anlotinib-induced hypertension, early prevention, a reasonable dosage regimen,
and appropriate treatment are critical to effectively manage anlotinib-induced hypertension. Additionally,
anlotinib-induced hypertension may be considered a marker for predicting efficacy.
Human Gut Microbiome: A New Frontier in Cancer Diagnostics & Therapeutics
Authors: Rani Vibha , Singhal Shivani , Sharma Kumkum , Vaid Rohan , Aggarwal Kanishka , Bhadana Renu , Agarwal Radhika , Atale Neha
Published: October 2021

The field of oncology is vast and ever-growing. The present cancer therapeutics is continually exhibiting
various drawbacks, which opens the door for exploring better novel therapeutic techniques. One such
emerging technique is the manipulation of gut microbiota to induce a positive curative effect in the body. The
dynamic gut microbiota of our body houses an astonishing number of microorganisms, mainly bacteria. The balance
of the gut microbiota is essential for good health as imbalances may result in dysbiosis leading to various
diseases such as cancer. The gut microbiota can be manipulated by using prebiotics, probiotics, synbiotics, postbiotics,
and antibiotics for better therapeutic outcomes, as well as to improve the quality of life of patients undergoing
conventional cancer treatment. Administration of bacteria as a probiotic agent accompanied with prebiotics
obtained from a wide variety of herbs has been used effectively to enhance the treatment of various cancers.
Although the theoretical basis of Gut therapy can be ascertained, further clinical trials will be essential to
determine the scope and limitations fully. The present review provides a glimpse of conventional and novel cancer
therapeutics and their drawbacks, along with the role of the gut microbiome and its modulation to design
new pharmaceutics against cancer.
Repurposing Drugs to Combat Drug Resistance in Leprosy: A Review of
Opportunities
Authors: Singh Pushpendra , Sharma Mukul
Published: October 2021

Leprosy is caused by extremely slow-growing and uncultivated mycobacterial pathogens,
namely Mycobacterium leprae and M. lepromatosis. Nearly 95% of the new cases of leprosy
recorded globally are found in India, Brazil, and 20 other priority countries (WHO, 2019), of
which nearly two-third of the cases are reported in India alone. Currently, leprosy is treated with
dapsone, rifampicin, and clofazimine, also known as multi-drug therapy (MDT), as per the recommendations
of WHO since 1981. Still, the number of new leprosy cases recorded globally has remained
constant in last one-decade, and resistance to multiple drugs has been documented in various
parts of the world, even though relapses are rare in patients treated with MDT. Antimicrobial
resistance testing against M. leprae or the evaluation of the anti-leprosy activity of new drugs remains
a challenge as leprosy bacilli cannot grow in vitro. Besides, developing a new drug against
leprosy through conventional drug development process is not economically attractive or viable for
pharma companies. Therefore, a promising alternative is the repurposing of existing
drugs/approved medications or their derivatives for assessing their anti-leprosy potential. It is an
efficient method to identify novel medicinal and therapeutic properties of approved drug molecules.
Any combinatorial chemotherapy that combines these repurposed drugs with the existing
first-line (MDT) and second-line drugs could improve the bactericidal and synergistic effects
against these notorious bacteria and can help in achieving the much-cherished goal of “leprosy-free
world”. This review highlights novel opportunities for drug repurposing to combat resistance to
current therapeutic approaches.
The Synthesis and Chemistry of Quinolinediones and their Carbocyclic
Analogs
Authors: Egu Samuel Attah , Onoabedje Efeturi Abraham , Okoro Uchechukwu Chris , Khan Khalid Mohammed , Hameed Abdul , Ali Irfan , Iftekhar Shafia , Odin Eboh Monday , Shamim Shahbaz
Published: October 2021

Quinoline-5,8-dione and naphthoquinone nuclei are very important substructures in industrial
chemicals and pharmaceuticals. These compounds exhibit a wide variety of activities, including
antifungal, antibacterial, antimalarial, antineoplastic, anticoagulant, anticancer, antiviral, radical scavenging,
antiplatelet, trypanocidal, cytotoxic, and antineoplastic activities. Currently, several research
articles on the importance of many natural and synthetic drugs containing quinolinequinone have
been reported. This review covers the progress in quinolinequinone and naphthoquinone chemistry
over the last five decades.
Development of a Quality Index Method Scheme for Sensory Assessment
of Chilled Yellowfin Tuna
Authors: Mai Nga T.T. , Olanrewaju Akin Y. , Le Luan V.
Published: October 2021

Background:

Quality monitoring and/or assessment are parts of a freshness/quality
control system, which is of utmost importance for fresh seafood, especially Scombridae fish.
The quality index method (QIM) is a simple, convenient, unique, and reliable tool to determine
the sensory status and estimate the remaining shelf life of aqua products.

Objective:

This study aimed to develop a QIM scheme for chilled stored yellowfin tuna and
apply the protocol in the fish quality evaluation and storage time estimation.

Method:

Eight gutted yellowfin tuna of 20, 30, and 40 kg up were used in the study. Five panelists
participated in the QIM development, training and application. Control and/or validation
analyses were sensory assessment by a control sheet, total volatile basic nitrogen (TVB-N)
quantification, and total viable count (TVC) determination. Chilled storage of tuna was performed
in liquid ice and traditional crushed block ice. Partial least square regression (PLS-R)
was conducted on quality index (QI) dataset over storage time to find the regression line and
prediction accuracy.

Results:

The established QIM protocol for gutted yellowfin tuna comprised 6 attributes (namely,
color of whole fish, odor of whole fish and flesh, eyes, appearance of whole fish, flesh color
and flesh texture) and a maximal QI of 15. The PLS-R showed that QI could be used to estimate
the remaining time with a precision of ± 2.0 and 1.4 days for fish stored in slurry ice and
crushed ice, respectively. The TVB-N content in the fish flesh maintained below the acceptable
level of 25 mg N/100 g throughout the storage period, which made the parameter impractical to
detect the fish shelf life. The TVC overreached the allowable level of 107 CFU/g around the
time of fish rejection by the sensory method.

Conclusion:

The developed QIM scheme for yellowfin tuna showed to be more advantageous
in detecting fish quality changes compared to the control sensory method and could be used to
estimate the fish's remaining shelf life.
BAPST. A Combo of Common Use Drugs as Metabolic Therapy for
Cancer: A Theoretical Proposal
Authors: Romo-Perez Adriana , Dominguez-Gomez Guadalupe , Chavez-Blanco Alma , Taja-Chayeb Lucia , Gonzalez-Fierro Aurora , Garcia-Martinez Elisa , Correa-Basurto Jose , Duenas-Gonzalez Alfonso
Published: October 2021

:

Cancer therapy advances have yet to impact global cancer mortality. One of the factors
limiting mortality burden reduction is the high cost of cancer drugs. Cancer drug repurposing has already
failed to meet expectations in terms of drug affordability. The three FDA-approved cancer
drugs developed under repurposing: all-trans-retinoic acid, arsenic trioxide, and thalidomide do not
differ in price from other drugs developed under the classical model. Though additional factors affect
the whole process from inception to commercialization, the repurposing of widely used, commercially
available, and cheap drugs may help. This work reviews the concept of the malignant
metabolic phenotype and its exploitation by simultaneously blocking key metabolic processes altered
in cancer. We elaborate on a combination called BAPST, which stands for the following
drugs and pathways they inhibit: Benserazide (glycolysis), Apomorphine (glutaminolysis), Pantoprazole
(Fatty-acid synthesis), Simvastatin (mevalonate pathway), and Trimetazidine (Fatty-acid
oxidation). Their respective primary indications are:
• Parkinson's disease (benserazide and apomorphine).
• Peptic ulcer disease (pantoprazole).
• Hypercholesterolemia (simvastatin).
• Ischemic heart disease (trimetazidine).
When used for their primary indication, the literature review on each of these drugs shows that
they have a good safety profile and lack predicted pharmacokinetic interaction among them. Based
on that, we propose that the BAPST regimen merits preclinical testing.
Green and Sustainable Technology: Efficient Strategy for the Synthesis of
Biologically Active Pyrimidine Derivatives
Authors: Sahoo Biswa Mohan , Kumar B.V.V Ravi , Panda Krishna Chandra , Sruti Jammula , Tiwari Abhishek , Patra Srimanta
Published: October 2021

:

Green chemistry is also referred to as sustainable technology, which involves the design,
synthesis, processing and the use of chemical substances by reducing or eliminating the chemical
hazards. This strategy focuses on atom economy, use of safer solvents or chemicals, use of raw materials
from renewable resources, consumption of energy and decomposition of the chemical substances
to non-toxic material which are eco-friendly. So, this technology is utilized for the sustainable
development of novel heterocyclic scaffold like pyrimidine derivatives. Pyrimidine is a six
membered heterocyclic aromatic compound with two nitrogen atoms at positions 1 and 3 in the
ring system. Among the other heterocyclic compounds, pyrimidine derivatives play a major role
due to their diverse promising biological activities, such as antimicrobial, antifungal, anti-viral, anti-
tubercular, anti-diabetic, anti-hypertensive, anticancer, anthelmintic, antioxidant, anti-epileptic,
antipsychotic, anti-anxiety, antimalarial, antihistaminic, anti-parkinsonian, analgesic and anti-inflammatory
etc. The various green methods used for the synthesis of pyrimidine derivatives include
microwave assisted synthesis, ultrasound induced synthesis, ball milling technique, grinding
technique and photo-catalysis. These processes enhance the rate of the reaction that leads to high selectivity
with improved product yields as compared to the conventional synthetic methods. This review
is focused on the green synthesis of biologically active pyrimidine derivatives.
An Evidence-Based Review of Medicinal Plants in the Overall Management of Chronic Fatigue
Authors: Tyagi Sakshi , Shekhar Nikhila , Thakur Ajit Kumar
Published: October 2021

Background:

Fatigue is generally a normal response to physical exertion
or any stressful situation. Its prevalence rates have reached the level of
1.5-3% among the general population. Due to the unclear etiology, diagnostic ambiguity,
and resultant heterogeneousness among the population, there is a lack of
a solid treatment regimen for fatigue. As the absolute treatment option is vague,
patients are moving towards complementary and alternative medicines. Hence it
is mandatory to review the efficiency of complementary and alternative therapies
along with herbal medicines.

Objective:

The purpose of this review is to carry out an evidence-based exploration
of the potentiality of medicinal plants in the treatment and management of fatigue.

Methods:

This evidence-based review was performed by conducting a literature
review of the available studies from the PubMed database.

Results:

The study was based on 23 pre-clinical and clinical studies. It showed
that medicinal herbs including Andrographis paniculata, Angelina sinensis, Astralagus
membranaceus, Cordyceps sinensis, Panax ginseng, Gymnostemma pentaphyllum,
Holy Basil, Lepidium meyenii, Rhodiola rosea, and Withania somnifera
that belong to various traditional medicinal systems such as Ayurveda and
Chinese Traditional Medicines can be a promising strategy to manage the various
forms of fatigue.

Conclusion:

On the basis of these studies, it was concluded that the medicinal
herbs and the phytochemicals within have a possible role in improving the symptoms
associated with fatigue which can be further validated to produce targeted
therapy for fatigue.
Electronic Properties and Pseudo-Electromagnetic Fields of Highly Conjugated Carbon Nanostructures
Authors: Bracamonte Angel Guillermo , Hutchinson William
Published: October 2021

:

In this communication, we discuss the particular electronic and quantum properties from graphene and carbon allotropes to highly conjugated carbon chemical structures from recent research. Moreover, the chemical modifications of these types of materials were analyzed against the concept of their inert properties, thus identifying that their surfaces could be modified to incorporate different properties, functionalities, and couple electronic effects, among others. Their versatility has been shown based on simple chemical reactions in controlled and targeted conditions of synthesis. Variable designs could be tuned from proof of concepts to functional materials for targeted applications. In addition, a proof of concept was discussed for Electron Transfer (ET) applications to show their electronic properties. Finally, the use of highly conjugated chemical structures to higher hierarchical ordered carbon structures, carbon nanotubes, graphene and carbon allotropes in electron and opto-responsive metamaterials, has been analyzed. Thus, new insights into multi-modal characteristics of materials have been discussed.
Advances in New Matter Properties and Applications of Hybrid Graphene-
Based Metamaterials
Authors: Bracamonte Angel Guillermo
Published: October 2021

:

Graphene as an organic material has attracted special attention due to its electronic
and conductive properties. Moreover, its highly conjugated chemical structures and relatively
easy modification have allowed varied design and control of targeted properties and applications.
In addition, this nanomaterial with pseudo-electromagnetic fields has led to the emergence
of photonics, electronics and quantum interactions with their surroundings, generating new
properties of materials. This short review aims at discussing many of these studies of new materials
based on graphene for light and electronic interactions, conductions and new modes of nonclassical
light generation. These new materials and metamaterials are being developed. For this
reason, some representative examples from research with potential applications have been
shown and discussed, in addition to their incorporation in real advanced devices and miniaturized
instrumentation. Accordingly, this special issue entitled “Design and Synthesis of Hybrid
Graphene-based Metamaterials” is intended to review the state-of-the-art in this multidisciplinary
field.
The impact of editorial policies and journal models on the number of articles on social humanities and communication studies related to Covid-19; Evidence from international and Indonesian scholarly work
Authors: Anshori Mahfud , Prabowo Henricus Hans Setyawan
Published: October 2021

This study examines scientific publications during a pandemic through bibliometric network analysis. We explored three different journal databases to map COVID-19 research in humanities and social sciences, then zoom in to communication studies. Government policy, e-learning, anxiety, economic impact are popular keywords in international and Indonesian articles on Social and Humanities, while disinformation, health communication, behavior change, and literacy are more prominent in communication articles. The researcher chose the keyword occurrence analysis as the basis for mapping the research theme. The bibliographic network was deployed in three strategies to obtain keyword data co-occurrence from research abstracts, keywords from researchers, and coder's approval keywords. Lastly, Vos viewer is used to creating macro and detailed perspective networks for interpretation. The results show that journal policies and models affect the number of COVID-19 publications in the journal. Finally, this study provides an overview that normative theory and behaviorism play a role in social and communication research.
Women and gender stereotyping in media from the point of view of structuration theory
Authors: Akalili Awanis , Sari Indah Olivia
Published: October 2021

This research is a thought process on social structure that is not understood as the consequence of human repetitive action. This has become folkways, causing gender stereotyping of women even more perpetuated by media's various narrations. This research aims to describe gender stereotyping of women in Indonesian television media. This was done by analyzing the broadcasting shows by using Gidden's theory of structuration. This descriptive research is a literary study that includes books, journals, researches and websites as the data. The collected data then analyzed by using Giddens' structuration theory. This article began with the review on structuration theory. Next is a review on structuration theory from the point of view of commmunication study. The gender stereotyping of women case in the media was then broken down and analyzed by using structuration theory. The result showed that the agent's action and the structure are inseparable, in harmony with Gidden's concept of duality. In fact, many women have put up a fight against this gender stereotyping through social-feminist movements. On the other hand, they actually do follow the existing structure both unconsciously and consciously. This structure, however, is still growing among the people of modern society.
Electronic Records With Tablets at the Point of Care in an Internal Medicine Unit: Before-After Time Motion Study
Authors: Pérez-Martí Montserrat , Casadó-Marín Lina , Guillén-Villar Abraham
Published: October 2021

Background

There are many benefits of nursing professionals being able to consult electronic health records (EHRs) at the point of care. It promotes quality and patient security, communication, continuity of care, and time dedicated to records.

Objective

The aim of this study was to evaluate whether making EHRs available at the point of care with tablets reduces nurses’ time spent on records compared with the current system. The analysis included sociodemographic and qualitative variables, time spent per patient, and work shift. This time difference can be used for direct patient care.

Methods

A before-after time motion study was carried out in the internal medicine unit. There was a total of 130 observations of 2 hours to 3 hours in duration of complete patient records that were carried out at the beginning of the nurses' work shifts. We calculated the time dedicated to measuring vital signs, patient evaluation, and EHR recording. The main variable was time spent per patient.

Results

The average time spent per patient (total time/patients admitted) was lower with the tablet group (mean 4.22, SD 0.14 minutes) than with the control group (mean 4.66, SD 0.12 minutes); there were statistically significant differences (W=3.20, P=.001) and a low effect (d=.44) between groups. The tablet group saved an average of 0.44 (SD 0.13) minutes per patient. Similar results were obtained for the afternoon shift, which saved an average of 0.60 (SD 0.15) minutes per patient (t34=3.82, P=.01) and high effect (d=.77). However, although there was a mean difference of 0.26 (SD 0.22) minutes per patient for the night shift, this was not statistically significant (t29=1.16, P=.25). The “nonparticipating” average age was higher (49.57, SD 2.92 years) compared with the “afternoon shift participants” and “night shift participants” (P=.007). “Nonparticipants” of the night shift had a worse perception of the project.

Conclusions

This investigation determined that, with EHRs at the point of care, the time spent for registration by the nursing staff decreases, because of reduced movements and avoiding data transcription. It eliminates unnecessary work that does not add value, and therefore, care is improved. So, we think EHRs at the point of care should be the future or natural method for nursing to undertake. However, variables that could have a negative effect include age, night shift, and nurses’ perceptions. Therefore, it is proposed that training in the different work platforms and the participation of nurses are fundamental axes that any institution should consider before their implementation.
An App-Based Just-in-Time Adaptive Self-management Intervention for Care Partners (CareQOL): Protocol for a Pilot Trial
Authors: Carlozzi Noelle E , Choi Sung Won , Wu Zhenke , Miner Jennifer A , Lyden Angela K , Graves Christopher , Wang Jitao , Sen Srijan
Published: October 2021

Background

Care partners (ie, informal family caregivers) of individuals with health problems face considerable physical and emotional stress, often with a substantial negative impact on the health-related quality of life (HRQOL) of both care partners and care recipients. Given that these individuals are often overwhelmed by their caregiving responsibilities, low-burden self-management interventions are needed to support care partners to ensure better patient outcomes.

Objective

The primary objective of this study is to describe an intensive data collection protocol that involves the delivery of a personalized just-in-time adaptive intervention that incorporates passive mobile sensor data feedback (sleep and activity data from a Fitbit [Fitbit LLC]) and real time self-reporting of HRQOL via a study-specific app called CareQOL (University of Michigan) to provide personalized feedback via app alerts.

Methods

Participants from 3 diverse care partner groups will be enrolled (care partners of persons with spinal cord injury, care partners of persons with Huntington disease, and care partners of persons with hematopoietic cell transplantation). Participants will be randomized to either a control group, where they will wear the Fitbit and provide daily reports of HRQOL over a 3-month (ie, 90 days) period (without personalized feedback), or the just-in-time adaptive intervention group, where they will wear the Fitbit, provide daily reports of HRQOL, and receive personalized push notifications for 3 months. At the end of the study, participants will complete a feasibility and acceptability questionnaire, and metrics regarding adherence and attrition will be calculated.

Results

This trial opened for recruitment in November 2020. Data collection was completed in June 2021, and the primary results are expected to be published in 2022.

Conclusions

This trial will determine the feasibility and acceptability of an intensive app-based intervention in 3 distinct care partner groups: care partners for persons with a chronic condition that was caused by a traumatic event (ie, spinal cord injury); care partners for persons with a progressive, fatal neurodegenerative disease (ie, Huntington disease); and care partners for persons with episodic cancer conditions that require intense, prolonged inpatient and outpatient treatment (persons with hematopoietic cell transplantation).

Trial Registration

ClinicalTrials.gov NCT04556591; https://clinicaltrials.gov/ct2/show/NCT04556591

International Registered Report Identifier (IRRID)

DERR1-10.2196/32842
The Functionality of Mobile Apps for Anxiety: Systematic Search and Analysis of Engagement and Tailoring Features (Preprint)
Authors: Balaskas Andreas , Schueller Stephen M , Cox Anna L , Doherty Gavin
Published: October 2021

BACKGROUND

A range of mobile apps for anxiety have been developed in response to the high prevalence of anxiety disorders. Although the number of publicly available apps for anxiety is increasing, attrition rates among mobile apps are high. These apps must be engaging and relevant to end users to be effective; thus, engagement features and the ability to tailor delivery to the needs of individual users are key. However, our understanding of the functionality of these apps concerning engagement and tailoring features is limited.

OBJECTIVE

The aim of this study is to review how cognitive behavioral elements are delivered by anxiety apps and their functionalities to support user engagement and tailoring based on user needs.

METHODS

A systematic search for anxiety apps described as being based on cognitive behavioral therapy (CBT) was conducted on Android and iPhone marketplaces. Apps were included if they mentioned the use of CBT for anxiety-related disorders. We identified 597 apps, of which 36 met the inclusion criteria and were reviewed through direct use.

RESULTS

Cognitive behavioral apps for anxiety incorporate a variety of functionalities, offer several engagement features, and integrate low-intensity CBT exercises. However, the provision of features to support engagement is highly uneven, and support is provided only for low-intensity CBT treatment. Cognitive behavioral elements combine various modalities to deliver intervention content and support the interactive delivery of these elements. Options for personalization are limited and restricted to goal selection upon beginning use or based on self-monitoring entries. Apps do not appear to provide individualized content to users based on their input.

CONCLUSIONS

Engagement and tailoring features can be significantly expanded in existing apps, which make limited use of social features and clinical support and do not use sophisticated features such as personalization based on sensor data. To guide the evolution of these interventions, further research is needed to explore the effectiveness of different types of engagement features and approaches to tailoring therapeutic content.
Exploring the methodology used to assess the influence of providing self-compassion education and training for parents and/or families when caring for their children: A systematic review protocol (Preprint)
Authors: Othman Shwikar Mahmoud Etman , Steen Mary , McKellar Lois , Wepa Dianne
Published: October 2021

UNSTRUCTURED

Aim and objective: To undertake a systematic review to assess the influence and impact of providing self-compassion education or training for parents and/or families when caring for their children.

Review methods: This systematic review will utilize the Joanna Briggs Institute (JBI) systematic review methodology. A three-stage comprehensive search of at least five electronic databases including Medline, Embase, PsychoInfo, Emcare and Cochrane library, as well as grey literature, will be conducted. Two independent reviewers will review the title and abstract of each paper to determine inclusion; all included papers will be appraised using the standardized critical appraisal instruments for evidence of effectiveness developed by JBI. This review will consider studies that include parents, mothers, fathers, family/families or expectant parents. Studies investigating education and/or training will be included, i.e., programs, workshops, seminars or sessions provided by all health care professionals/health and social workers/counsellors, psychologists, nurses, midwives, meditation practitioners, and mindfulness trainers. In addition, this review will consider studies that evaluate or measure any type of self-compassion education or training, i.e., programs, workshops, seminars, sessions targeted for parents, mothers, fathers, family/families or expectant parents. Self-compassion education and/or training may be provided face-to-face, one-to-one, group work, webinar, digital or online, programs, workshops, parental education classes or simulation classes, seminars, sessions. This review will include any randomized controlled trials, quasi-experimental studies, cohort studies and case-controlled studies, before and after studies, and mixed-method studies.
Studies will only be considered if they include the following outcome measures: measuring self-compassion (self-kindness, common humanity, mindfulness), fear of compassion and any outcome for health and wellbeing of parents/families, and these will be reported in a column in the summary table of all included studies. The review outcomes will be reported on both continuous and dichotomous scales, where possible findings will be pooled for reporting using JBI tools.

Implication: The findings of this systematic review will guide further research on developing, designing, facilitating and evaluating self-compassion education and training programs, workshops, sessions for parents and families.

PROSPERO registration:

This systematic review title is registered at the International Prospective Register of Systematic Reviews: CRD42021225021