bluuebunny/crossref_metadata_2025 huggingface dataset:
The End
Authors: Constantin Danielle
Published: November 2023

Cet article pose un regard nouveau sur le dénouement de La Vie mode d’emploi de Georges Perec, en s’appuyant sur l’analyse génétique de documents de la phase rédactionnelle. Dans un premier temps, l’incipit et la chute du premier chapitre, tels que Perec les met au net dans ses cahiers, montrent comment le texte présage sa fin et ce, dès son commencement. Puis nous passerons à une analyse de la fin du roman, comme elle se présente dans les plans, notes et manuscrits du chapitre xcix (mort de Percival Bartlebooth), de l’épilogue (mort de Serge Valène), mais aussi de l’avant-dernier chapitre (xcviii) ; celui-ci nous offre une finale plus heureuse (achat d’un lit conjugal, naissance) et fait discrètement contrepoids à la conclusion doublement mortuaire du roman. L’article dévoile la dimension visuelle et matérielle du travail de Perec, ainsi que la double articulation prospective et rétroactive de processus scripturaux menant vers une finale longtemps désirée et même déjà écrite. Ce dénouement évoque à son tour, bien qu’implicitement, les débuts de la genèse, en inscrivant dans les derniers paragraphes du roman le souvenir d’un plan esquissé par l’écrivain.
Analgesic efficacy of intra-peritoneal instillation of dexamethasone and bupivacaine versus bupivacaine following laparoscopic cholecystectomy – A randomised, double-blind controlled study
Authors: Vandana Pakhare , Ananya Nanda , Muralikrishna D , Ponduru Supraja , Renganathan Vyshnavi , Gopinath Ramchandran
Published: November 2023

Background and Aims:

Laparoscopy is associated with acute pain. We compared the effectiveness of intra-peritoneal dexamethasone with bupivacaine versus bupivacaine in patients undergoing laparoscopic cholecystectomy for postoperative analgesia.

Methods:

This randomised study was conducted after approval from the institutional ethics committee and 84 patients were randomly allocated into bupivacaine with dexamethasone group (BD) (received 40 mL of 0.25% bupivacaine with 16 mg dexamethasone), and bupivacaine group (BB) (received 40 mL of 0.25% bupivacaine intra-peritoneally). Data analysis was done using R version 4.2.1. The visual analogue scale (VAS) score, total rescue analgesic dose, and time required for the first analgesic between groups were compared using the Wilcoxon rank sum test or t-test appropriately.

Results:

VAS score was significantly lower in the BD group compared to the BB group until 2 h post-operatively with a mean difference of − 1.0 (95% confidence interval [CI] −1.5, −0.53), P < 0.001. The total rescue analgesic dose consumed was lower in the BD group (60.71 mg [29.80]) compared to the BB group (73.20 mg [11.57]) with a mean difference of − 12.5 mg (95% CI − 22.3, −2.68), P = 0.013. In addition, the time taken for the requirement of the first rescue analgesic was significantly longer in the BD group (417.1 min [276.0]) compared to the BB group (219.4 min [226.1]) with a mean difference of 197.7 (95% CI 75, 320), P = 0.002.

Conclusion:

Intra-peritoneal instillation of 16 mg dexamethasone with 0.25% bupivacaine in laparoscopic cholecystectomy significantly reduces post-operative pain and requirement of rescue analgesic compared to 0.25% bupivacaine alone.
Role of midazolam on cancer progression/survival - An updated systematic review
Authors: Sethi Ansh , Rezk Amal , Couban Rachel , Chowdhury Tumul
Published: November 2023

Background and Aims:

Cancer is a leading cause of mortality worldwide. Despite advancements in cancer management, cancer progression remains a challenge, requiring the development of novel therapies. Midazolam is a commonly used adjunct to anaesthesia care for various surgeries, including cancer. Recently, there has been a growing interest in exploring the potential role of midazolam as an anticancer agent; however, the exact mechanism of this linkage is yet to be investigated thoroughly.

Methods:

Based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline, this systematic review presented aggregated evidence (till November 2022) of the effects of midazolam on cancer progression and survival. All primary research article types where midazolam was administered in vivo or in vitro on subjects with cancers were included. No restrictions were applied on routes of administration or the type of cancer under investigation. Narrative synthesis depicted qualitative findings, whereas frequencies and percentages presented numerical data.

Results:

Of 1720 citations, 19 studies were included in this review. All articles were preclinical studies conducted either in vitro (58%, 11/19) or both in vivo and in vitro (42%, 8/19). The most studied cancer was lung carcinoma (21%, 4/19). There are two main findings in this review. First, midazolam delays cancer progression (89%, 17/19). Second, midazolam reduces cancer cell survival (63%, 12/19). The two major mechanisms of these properties can be explained via inducing apoptosis (63%, 12/19) and inhibiting cancer cell proliferation (53%, 10/19). In addition, midazolam demonstrated antimetastatic properties via inhibition of cancer invasion (21%, 4/19), migration (26%, 5/19), or epithelial-mesenchymal transition (5%, 1/19). These anticancer properties of midazolam were demonstrated through different pathways when midazolam was used alone or in combination with traditional cancer chemotherapeutic agents.

Conclusion:

This systematic review highlights that midazolam has the potential to impede cancer progression and decrease cancer cell survival. Extrapolation of these results into human cancer necessitates further investigation.
Efficacy of cryoneurolysis versus intra-articular steroid in sacroiliac joint pain: A retrospective, case-control study
Authors: Das Gautam , Das Suspa , Sahoo Rajendra , Shreyas Sneha , Kanthi Basabraj , Sharma Vikas S
Published: November 2023

Background and Aims:

Intra-articular steroids provide significant pain relief in sacroiliac joint pain (SIJP), but their action is short-lived. Cryoneurolysis is reported to produce prolonged pain relief in various pain conditions. However, its efficacy has not been evaluated in patients with SIJP. Thus, we compared the efficacy of cryoneurolysis with steroid injections in adult patients with SIJP.

Methods:

This retrospective healthcare records review–based study involved 83 patients with SIJP. Patients were divided into two groups: cases (sacroiliac joint [SIJ] cryoneurolysis, n = 39) and controls (SIJ steroid injection, n = 44). An 11-point numeric pain rating scale (NPRS) was used to assess the pain severity at baseline and immediately, 1, 3 and 6 months post-intervention. A reduction of ≥50% in NPRS score immediately following SIJ cryoneurolysis and steroid injection was considered a successful outcome. The difference between the treatment groups was assessed with a Chi-square test, and P < 0.05 was considered statistically significant.

Results:

Both cases and controls showed significantly decreased NPRS scores from baseline to immediately, 1 month, 3 months and 6 months postintervention (P < 0.001). However, compared to controls, cases had significantly lower NPRS scores at all time points (all P < 0.001). Moreover, a significantly greater proportion of cases had ≥50% decrease in NPRS score from baseline, that is, 1 month (97.44% vs. 75%, P = 0.004), 3 months (100% vs. 47.73%, P < 0.001) and 6 months (69.23% vs. 27.27%, P < 0.001).

Conclusion:

Although both cryoneurolysis and intra-articular steroid injections provide significant pain relief immediately, 1, 3 and 6 months postintervention, cryoneurolysis resulted in significantly greater pain relief.
A Novel 1-ϕ Cuk Based On-Board EV Charger with Minimal Power Components
Authors: Chamarthi Phani Kumar , Edrington Christopher , Arsalan Ali , Timilsina Laxman , Papari Behnaz , Ozkan Gokhan , Moghassemi Ali
Published: November 2023

This paper proposes a novel 1-ϕ, Cuk based on-board electric vehicle (EV) charger with least power components. The proposed EV charger has a special feature to achieve power factor correction (PFC) at AC grid without requirement of the grid voltage and current sensors which cuts the cost and increases the power density of the EV charger along with robustness to noise. The automatic PFC at AC grid is accomplished by operating the output DC inductor in discontinuous conduction mode (DCM). The proposed EV charger necessitates a minimal number of power components for positive and negative half cycles of AC grid which improves the overall efficiency of the system. This is possible due to the combination of inverting and non-inverting Cuk converters are used for each half cycle of the AC grid. Further, the presence of output inductor in the EV charger reduces the ripples in the output current which is not common with all the existing chargers in the literature. In addition, the control of charger is simple, and easy to implement with only battery current sensor based current control. The proposed charger configuration has lower voltage stress across the power switches and diodes in comparison with the existing charger configurations. The theoretical concept is validated through experimental studies which prove the superior execution of PFC control of the 2kW EV charger. The various performance factors such as power factor at AC grid is 0.996 and total harmonic distortion (THD) in the AC grid current is 2.8% which are within the limits of standard IEC 61000-3-2.
Descriptive survey of pharmacy students’ self-evaluation of Advanced Pharmacy Practice Experiences (APPE) and practice readiness using entrustable professional activities
Authors: Farris Charlotte , Fowler Meredith , Wang Sophia , Wong Emily , Ivy Delaney
Published: November 2023

Objective: To evaluate pharmacy students’ self-identified levels of entrustability before and after their advanced pharmacy practice experiences (APPE).
Methods: Third and fourth-year pharmacy students completed a Qualtrics survey where they were asked to self-identify their entrustability level (scale of I–V) on each of the fifteen core entrustable professional activities (EPAs) for pharmacy graduates.
Results: A total of 249 third-year students completed the APPE-readiness survey in the Fall of 2017–2019, and 106 fourth-year students completed the practice-readiness survey in the Spring of 2018. The highest entrustability level in both surveys was “create a written plan for continuous professional development”. The lowest reported entrustability levels in both surveys were: “Oversee the pharmacy operations…”, “Maximise the appropriate use of medications…,” and “Establish patient-centred goals and create a plan…”. The largest area of change from pre-APPE to post-APPE was overseeing pharmacy operations, with an increase of 26%. The average pre-APPE entrustment level was 3.72, increasing to 4.2 in the practice readiness portion. The percentage of students self-reporting below an entrustment level of 3 in the practice-readiness survey ranged from 0–0.99%.
Conclusion: Pharmacy students increased their self-reported level of entrustability over all 15 EPA domains from pre-APPE to post-APPE year.
A CONCEPTUAL STUDY ON THE EFFECT OF CHINCHA PATRA NALIKERA POTTALI SWEDANA IN THE MANAGEMENT OF VATA KAPHAJA GRIDHRASI
Authors: PS Revathy , Rajan Amritha
Published: November 2023

Swedana is an important aspect of Panchakarma which helps to liquify the vitiated Doshas that have spread throughout the microchannels of the body. Swedana Karma is a Poorva Karma as well as a Pradhana Karma for the treatment of various diseases. Acharya Charaka mentioned Swedana Karma as one among the Sha-dupakrama and as the prime treatment modality for various diseases, especially in Vata and Kapha dominant conditions. Pinda Sweda is one among the 13 types of Saagni Sweda as explained by Acharya Charaka and Pinda Sweda is a type of Ushma Sweda according to Astanga Sangraha. Chincha Patra Nalikera Pottali Swedana is a type of Rooksha- Snigdha Sweda and a form of Ushma Sweda. The treatment procedures men-tioned in classics for Gridhrasi include Snehana, Swedana, Virechana, Basti and Agnikarma. Among these in Vata Kaphaja Gridhrasi, Swedana is explained as one of the major treatment modalities as per Chakradatta and Gadanigraha.
A REVIEW ON AGNIKARMA AND ITS PROBABLE MODE OF ACTION
Authors: mol S Shalu , Benedict P , Sivakumar C.S
Published: November 2023

Salyatantra is one among the important and vital branches of Ayurveda, which consists of various surgical and para
surgical procedures. Agnikarma or thermal cauterization is the foremost among these para surgical procedures. It
means application of heat to the body part directly or indirectly with help of different materials to prevent or to cure
a disease. It is a potent and minimally invasive para surgical procedure which has wide application in chronic
conditions as well as in emergency management. Agnikarma has been given special place in surgery by Susruta and
the disease treated by Agnikarma never reoccurs. Clinically it is considered as prime para surgical procedure and it
provide relief in certain diseases which are not cured by herbal medicine, surgical interventions and alkaline cauterization. Based on specific heat retention and transmission capacity of different substances acharyas had prescribed different materials for cauterizing specific body parts. Most commonly Agnikarma is indicated in neurogenic pain, tendinopathies, or in diseases of skin, vein, ligament, bone or joint where pain is an exclusive factor.
The preventive, curative and haemostatic properties of Agnikarma were known even centuries back.
Normal and Reversed Phases Thin-Layer Chromatography of Arylidene 2- Thiohydantoin Derivatives
Authors:   University of Kragujevac, Institute for Information Technologies, Serbia, Stanić Petar B. , Šmit Biljana ,   University of Kragujevac, Institute for Information Technologies, Serbia, Muškinja Jovana ,   University of Kragujevac, Institute for Information Technologies, Serbia, Soldatović Tanja ,   State University of Novi Pazar, Department of Natural-Mathematical Sciences, Serbia, Ilić Marko ,   University of Novi Sad, Faculty of Technology Novi Sad, Serbia, Pastor Kristian ,   University of Novi Sad, Faculty of Technology Novi Sad, Serbia, Ačanski Marijana ,   University of Novi Sad, Faculty of Technology Novi Sad, Serbia
Published: November 2023

In this paper, the retention behavior of thirteen newly synthesized arylidene derivatives of 2-hydamthione was investigated by normal and reversed phases thin-layer chromatography. In normal phase chromatography, thin layers of silica gel and cyano-propyl (CN) silica gel with fluorescent indicator F254 were used as the stationary phase. As the mobile phase, binary systems of non-aqueous solvents benzene-ethyl acetate and hexane-ethyl acetate were used, 8:2 (v/v). Reversed phase chromatography was performed using a thin layer of octadecyl (C-18) silica gel with fluorescent indicator F254 as the stationary phase and a binary solvent mixture of acetonitrile-water in the ratio 7.5:2.5 (v/v) as the mobile phase. Observing under a UV lamp, the spots of all tested derivatives were clearly visible. The RF value was determined for each spot. Based on the obtained results the HPLC technique is recommended for further chromatographic examination of the newly synthesized arylidene derivatives of 2-hydamthione, using commercial columns with polar chemically bound phases and both non-aqueous and aqueous eluents.
Qualitative content of selected phenolic compounds in different extracts of plant species Iris pumila L.
Authors:   University of Kragujevac, Faculty of Science, Department of Biology and Ecology, Kragujevac, Serbia, Đelić Gorica , Pavlović Milica ,   University of Kragujevac, Faculty of Science, Department of Biology and Ecology, Kragujevac, Serbia, Velicković Vesna ,   University of Kragujevac, Faculty of Technical Sciences Čačak, Serbia
Published: November 2023

The aim of this paper is to determine the content of selected phenolic compounds and to find the appropriate optimal extraction agent for the extraction of phenolic compounds from the plant species Iris pumila L. The content of total phenols and flavonoids in the rhizome and aboveground parts of the plant was determined by the application of the spectrophotometric method in the examined extracts obtained by the maceration method. By comparatively analyzing the application of two solvents for extraction, we concluded that the application of methanol in the conventional maceration technique contributes to a higher yield of phenolic compounds. Using methanol as a solvent, it was found that the content of selected phenolic compounds in the rhizome (28.57 mg/g extract total phenolic and for total flavonoids 24.21 mg/g extract) compared to ethyl acetate as solvent. Tested extracts of parts of Iris pumila L. plant contain high levels of phenolic compounds and are suitable for use as a source of compounds with pronounced antioxidant activity.
Building a 3D QSAR model with isopropylidene analogs of cytotoxic styryl-lactones
Authors:   University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, Serbia                     Serbia, Levovnik Bojan D. , Alargić Aleksa P. ,   University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, Serbia                     Serbia, Svirčev Miloš M. ,   University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, Serbia                     Serbia, Benedeković Goran I. ,   University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, Serbia                     Serbia
Published: November 2023

Styryl-lactones are a class of natural products and related analogs that exhibit diverse biological activities, including anticancer, anti-inflammatory, and antimicrobial properties. Since these compounds are routinely obtained in our laboratory from their O-isopropylidene precursors, we envisioned the project to examine and compare their respective structures and in-vitro activities. This paper presents a basic 3D-QSAR steric model built on a small set of 11 selected O-isopropylidene and styryl-lactone (particularly [3.3.0]furofuranone) ligands and their in vitro activities against an MCF-7 cell line. It is part of a larger ongoing study that encompasses synthesis as well as in vitro and in silico testing of a growing library of natural products and their analogs, with the aim to determine their pharmacophores, molecular targets, and cellular mechanisms of action.
Validation of gravimetric method for determination of clay in soil
Authors:   University of Kragujevac, Faculty of Science, Department of Chemistry, Serbia, Uđilanović Marina , Ćirić Andrija ,   University of Kragujevac, Faculty of Science, Department of Chemistry, Serbia
Published: November 2023

The requirements for method validation are taken from the method ISO 11277:2020 Soil quality – determination of particle size in soil – by sieving and sedimentation method, Annex C table C.1 [1]. The validation was performed on soil samples and on soil reference material (old PT scheme). Validation includes checking the volume of the pipette i.e., calibration of the pipette, correction for the contribution of the dispersing agent, repeatability (RSDr), reproducibility (RSDR), recovery (R), checking bias from the used lab equipment and the bias from purity of use chemicals. As a final part of the validation, the combined measurement uncertainty (Uc) and expanded measurement uncertainty (U) with a confidence level of 95% were calculated. The pipette calibration error is 2.40%. The obtained results are RSRr = 1.38%, RSDR = 13.21%, Recovery = 100.66%, laboratory equipment bias is 2.66%, bias from used chemicals is 0.17%, combined uncertainty is 5.08% and expanded measurement uncertainty is 10.17% by gravimetric determination of clay content, using the pipette method.
Nutritional Status and Dietary Profile of College Students - A Cross Sectional Study from South India
Authors:   Department of Nutrition and Dietetics, Alagappa University, Karaikudi, Tamilnadu, India, Gomathirajyashyamala Dr. L. , Anitha Dr. R. ,   Department of Foods and Nutrition, Muthurangam Govt Arts College (A), Vellore, Tamilnadu, India, Rameshthangam Dr. P. ,   Department of Nutrition and Dietetics, Alagappa University, Karaikudi, Tamilnadu, India
Published: November 2023

Background: Undernutrition is most critical health challenges facing society today, not just in terms of health, but also health care expense. Several studies have revealed that college students often have bad eating habits. Students typically consume less fruits and vegetables per day and report a high intake of high-fat, high-calorie items. Aims: The purpose of this study was to assess nutritional status and dietary habits of students studying in university. Materials and Methods: A cross-sectional survey was conducted among a sample of post graduate students with the sample size of 57. A well-structured interview schedule was used for data collection regarding socio demographic data, nutritional status and dietary profile. Results and Discussion: Outcome of the results indicated that majority of them were belonged to the age category of 21-25 years, stayed in hostel, had one sibling and were middle class families. Around 50.6 % of college students were within the healthy Body Mass Index range. Most students showed ‘satisfactory’ dietary habits. Almost more than half of the students reported consuming good amounts of fruits, vegetables, milk and nuts daily. Only 8.8 % of students were eating non-vegetarian daily. Conclusion: Around 50% of college students, particularly females, were within the range of good nutritional status. Students’ dietary habits were satisfactory. However, students’ knowledge of good diet habits, and nutritional knowledge needs to be improvement. This study offers new insight for formulating policies and intervention programs among college students in the future.
Strategic Management of COVID 19 Pandemic; Response and Preparedness in Sri Lanka
Authors:   Deputy Director General Medical Services I, Ministry of Health Sri Lanka, PWC Panapitiya , GSP Ranasinghe ,   Director Primary Care Services, Ministry of Health Sri Lanka, DARK Dilrukshi ,   Medical Superintendent Base Hospital Panadura, BAHM Gunasena ,   Deputy Director Teaching Hospital Badulla, GHS Fernando ,   Medical Superintendent Base Hospital Udugama
Published: November 2023

Serious pandemic of COVID -19 a highly contagious respiratory disease caused by the Severe Acute Respiratory Syndrome Corona Virus 2, which was first discovered in December 2019 in the city of Wuhan. This highly infective SARS-CoV-2 virus is spreading from person to person through close contact, and the common symptoms include fever, cough and shortness of breath while muscle pains, loss of smell and taste, diarrhea, abdominal pain and throat ache are other symptoms, which have frequently recorded. This serious pandemic of COVID -19 has threatening lives of people and claimed 682,421,707 patients and 6,819,238 deaths worldwide to date of 19th March 2023. The first COVID-19 case in Sri Lanka on 27th January 2020, who was a 44 year old female tourist from Hubei Province China, and the first local case was reported on 11th of March 2020, who was a travel guide. Aim of this article is to describe the effectiveness of COVID-19 response and preparedness especially on patient care management. A descriptive study was conducted through Key Informant Interviews, data gathering through desk review of records and reports published. Multi strategic approach that was used in the Sri Lankan health sector to combat COVID – 19 pandemic. Strategies done were; system development (curative and preventive services), infrastructure development and improvement of facilities, staff wellbeing and protection, continuation of normal patient care services, intersectoral coordination and collaboration, special projects in relation to COVID – 19 pandemic, leadership and governance, supervision and monitoring, and public / community empowerment. These strategies has reflected in managing COVID – 19 pandemic and similar strategies with modification can be implemented in future pandemic situations. Further, it is recommended to do in-depth studies to understand the interventions done in specific areas, effectiveness of interventions, and gaps of intervention done and to mitigate the gaps for better response system in order to build a resilient health system.
Financial Performance Analysis Before And After Acquisition and its Impact on Sustainable Growth Rate in the Pharmaceutical Industry
Authors: Riyadi Selamet , Suhardiah Ida , Damayanti Deni Ratna
Published: November 2023

This research aims to understand and analyze whether there is a difference in Current Ratio (CR), Debt-Equity Ratio (DER), Total Assets Turnover (TATO), Inventory Turnover (ITO), Net Profit Margin (NPM), Return On Assets (ROA) , Return On Equity (ROE) before and after acquisition, as well as whether there is an influence of Debt-Equity Ratio (DER), Total Assets Turnover (TATO), Current Ratio (CR) and Return On Assets (ROA) on Sustainable Growth Rate (SGR) in the Pharmaceutical Industry listed on the Indonesian Stock Exchange (IDX) and the National Stock Exchange of India (NSE) which carried out acquisitions in 2012-2022. The research method used is a quantitative method based on secondary data and the population of Pharmaceutical Industries registered on the IDX and NSE India, then non-probability sampling - purposive sampling was carried out. Data testing and hypothesis testing were carried out with the help of IBM Statistics SPSS 25, namely the Wilcoxon Signed Rank Test, Kendall's tau test, multiple regression test, t statistical test, and F statistical test. The test results showed that there was a significant difference for the Total Assets Turnover (TATO), Inventory Turnover (ITO), Return On Assets (ROA), and Return On Equity (ROE) between before and after the acquisition, and there is a significant influence of Total Assets Turnover (TATO), Current Ratio (CR), dan Return On Assets (ROA) partially on the Sustainable Growth Rate (SGR) and there is an influence of the Debt-Equity Ratio (DER), Total Assets Turnover (TATO), Current Ratio (CR) and Return On Assets (ROA) simultaneously affect the Sustainable Growth Rate (SGR).
Execution Policy for Finance and Accounting Department: Basis for Implementation and Acquisition Management
Authors:   University Research Director Universidad De Manila, Caday, DBA Ma. Aurora T.
Published: November 2023

The paper investigates the execution policy for the finance and accounting department as a basis in the implementation and acquisition management. It aims to answer the extent of policy execution for both finance and accounting in the implementation and acquisition management in fund flow arrangement, finance and accounting policy procedure, budgeting system, safeguard over assets, and contract management. Quantitative research design is employed in the study. It gathers and quantifies the data for statistical treatment on the measure of the variables. Likewise, purposive sampling is employed in the selection of the sample population in the study. It all gathers the necessary respondents under the jurisdiction of the Vice-President Comptrollership such as Planning and Budget Department, Accounting, Supplies etc. The study comprised Eighteen (18) respondents only. Results show that fund flow arrangement establishes a policy that is capable of the transaction process in handling and promptness of the policy and execution of the acquisition, show policy and procedures describes finance and accounting retention record to support the documents of the process, show budgeting system is being followed upon request of budget in advance or after fact among the respondents, show safeguard over assets have the procedures and policies that are adequate to safeguard and to protect the assets in place for the accounting and finance integrity from any waste, fraud, and abuse which is identified for the accounting and financial execution process, and show that contract management indicates the procedures and policies for acquisition implementation and execution and is being maintained for both the accounting and finance for all the acquisition in the organization.
Control of Acute Pain in a Patient with Acute Chronic Low Back Pain by Using Ecoguided Facetary Analgesic Blockin the Emergency Room, Report of Two Cases
Authors:   Emergenciologist / Master In Pain General Hospital Zone #2 Imss, Hermosillo, Sonora, Mexico, Garcia Dr. Israel Morales , Sanchez Salas Dr. Gibran Guadalupe ,   3rd Year Resident of Medical Surgical Emergencies General Hospital Zone #2 Hermosillo, Sonora, Mexico
Published: November 2023

Low back pain is one of the most frequent causes of disability, it is a problem that is characterized by its high prevalence in the population and its economic and social repercussions, becoming one of the main causes of work absenteeism. In this entity, there is an association between muscular and psychosocial factors that generate avoidance behaviors, fear and muscle atrophy, causing a vicious circle that favors chronicity and disability. The prevalence of this syndrome is 60-85% during the survival of individuals. Between 15 and 20% of adults suffer from low back pain; in 90% of cases it is non-specific, it affects both men and women, and occurs more in ages between 30 and 50 years; increasing prevalence with age. The most important challenge in the diagnosis of low back pain is to differentiate the 95% whose origin is benign musculoskeletal processes, from the 5% whose low back pain is caused by specific diseases that require rapid and adequate treatment. In this task, the warning signs that help to rule out the most serious processes can be useful. The warning signs in low back pain are: age >50 years, history of neoplasia, constitutional syndrome, no improvement with usual treatments, pain at rest, fever, immunosuppression, previous trauma, osteoporosis, taking corticosteroids and cauda equina syndrome. It should also be noted that in approximately 80% of cases it will not be possible to arrive at a specific diagnosis. Thanks to advances in imaging, neural anatomical findings, new discoveries in the chemical mediation of pain, the development of ultrasound-guided injection techniques, we have greater diagnostic and therapeutic accuracy, and the highest success rate in non-surgical treatments have facilitated the expansion of minimally invasive techniques in pain management. On this occasion, two patients with pain at the level of the intense lumbar region are presented, who were managed with opioid analgesics, NSAIDs without pain improvement, in both cases ultrasound-guided fascetarian blocks were applied, with pain remission on a VAS scale of 10 /10 to 1/10, being discharged from the service.
Factors Associated with Subjective Work Fatigue in Gas Station Pump Attendants
Authors:   Department of Public Health, Faculty of Public Health, Universitas Andalas, Indonesia, Gusti Aria , Anggraini Dea ,   Department of Public Health, Faculty of Public Health, Universitas Andalas, Indonesia, Anshari Luthfil Hadi ,   Department of Public Health, Faculty of Public Health, Universitas Andalas, Indonesia
Published: November 2023

The Padang-Solok route is the busiest causeway in West Sumatra. Has 3 Gas Stations with high traffic. Based on a preliminary study, 66.6% of Gas Station pump workers experience severe work fatigue. The study aimed to determine the relationship between factors and fatigue at Gas Station pump workers. This type of quantitative research uses a cross-sectional approach from February to August 2023. The population and sample are 42 people using the total sampling method. The research instruments were questionnaires, scales, stadiometers, and WBGT. Primary and secondary data collection. Univariate and bivariate data processing with the Chi-Square test with a degree of confidence of 95% (α = 0.05. The results showed that 59.5% of respondents experienced severe fatigue, 16.7% were old, 42.9% were female, 33.3% had abnormal BMI, 21.4% had long working hours, 35.7% worked at high temperatures, and 59.5% had poor sleep quality. The statistical test results showed a significant relationship between gender (p- p-value=0.002), nutritional status/BMI (p-value=0.005), sleep quality (p-value=0.020), and work fatigue. There is no significant relationship between age (p-value=0.210), years of service (p-value=0.60), and ambient temperature (p-value=0.708) with work fatigue. There is a relationship between gender, nutritional status/BMI, and sleep quality with work fatigue among pump workers. It is recommended that Gas Stations complete rest facilities and provide drinking water and chairs in the pumping machine unit.
The Influence of Formative Feedback and Learning Style Towards the Students’ Ability in Narrative Writing an Experimental Study to the Students of Sma Negeri 1 Tibawa
Authors:   71. Jenleral sudirman No.6 Kotn Gorontalo 96123. 4NG Gorontalo Indonesia, Fatsah Hasanuddin , Yunginger Ester ,   71. Jenleral sudirman No.6 Kotn Gorontalo 96123. 4NG Gorontalo Indonesia, Talib Rasuna ,   71. Jenleral sudirman No.6 Kotn Gorontalo 96123. 4NG Gorontalo Indonesia, Miolo Sartin ,   71. Jenleral sudirman No.6 Kotn Gorontalo 96123. 4NG Gorontalo Indonesia
Published: November 2023

This research investigated the influence of formative feedback strategy and learning style on the narrative writing ability of the Tenth grade students of SMA Negeri 1 Tibawa. This research isan experimental study usingfactorial design, the data were analyzed by using Two-Factor Anova at significance level α 0,05. There were 84 students under investigation, which were determined randomly through multi-stage random sampling. The result of the research indicate that: (1) the narrative writing ability of the students who learned with written feedback formative strategy is higher than those who learned with spoken feedback formative strategy, (2) the narrative writing ability of the students whose visual learning style is higher than those whose auditory learning style, (3) there’s influence interaction between formative feedback and learning style toward the students’ ability in narrative writing, (4) the narrative writing ability of the students with visual learning style, and learned with written feedback strategy is higher than those who learned with spoken feedback strategy, (5) the narrative writing ability of the students who learned with written feedback strategy, the visual is higher than auditory, (6) the narrative writing ability of the students who learned with spoken feedback strategy, the visual is lower than the auditory
Overwhelming Legislative Intervention and its Impact on NE State of Manipur
Authors:   Head & Associate.Professor Dhanamanjuri University,Manipur, Singh Dr. N. Pramod
Published: November 2023

Law maker occupies a significant status and position in a state. The very purpose of legislation is not only to serve for the welfare and happiness of the people but also to harmonize the relation between the state and its citizens. Every legislation ought to be the expression of the will of general masses. An ideal state requires just, fair and reasonable law that essentially aims to promote and protect the rights and freedoms of citizens of this country. On the other hand, such law shall not overstep its legitimate boundary because the ultimate end of the law in a democratic country is to render justice to all the needy people without discrimination. Law is an instrument of social change and it invariably occupies a significant position in every human society. It always aims to harmonise the relation between the rulers and their subjects, as it happens to be the connecting link between the two entities. It also facilitates to construe a good governance inter alia a friendly atmosphere between the state and its citizens for which observance of due respect to the principles of rule of law and constitutionalism remains yet to be realized, especially for maintaining peace, harmony and development in the NE state of Manipur
Setmelanotide (Imcivree)
Authors: CADTH
Published: November 2023

CADTH recommends that Imcivree be reimbursed by public drug plans for weight management in adult and pediatric patients 6 years of age and older with obesity due to Bardet-Biedl syndrome (BBS) if certain conditions are met.

Imcivree should only be covered for patients who are aged 6 years and older and have a clinically or genetically confirmed diagnosis of BBS and obesity.

Imcivree should only be reimbursed if prescribed by an endocrinologist, pediatric endocrinologist, and/or specialist in weight management or obesity and the cost of Imcivree is reduced. When first prescribed, Imcivree should only be reimbursed for 26 weeks. Reimbursement may be renewed on a yearly basis for patients who experience a clinically meaningful decrease in body weight or body mass index (BMI).
RESPONSABILIDADES DOS FABRICANTES NO CÓDIGO DE DEFESA DO CONSUMIDOR
Authors: Sá Felipe Alves de
Published: November 2023

As empresas são instituições de grande relevância no ordenamento jurídico, pois constituem fator determinante para o desenvolvimento econômico, social, tecnológico, entre outros; o que significa que estão sujeitas ao cumprimento de múltiplos deveres, os quais, em última instância, visam orientar a forma como a referida entidade deve comportar-se nas diversas circunstâncias e mesmo em relação aos seus procedimentos. Porém, mesmo tendo um papel fundamental, em muitas ocasiões, as empresas, ao invés de terem um efeito positivo, exercem uma influência negativa, a ponto de poderem causar danos ou efeitos negativos aos seus destinatários, consumidores, o que se vê refletido em sua vida, saúde e meio ambiente; e, nessa medida, dão origem à responsabilidade. Assim este artigo tem por objetivo analisar as principais responsabilidades dos fabricantes ao fornecerem seus produtos no mercado.  Para se atingir o objetivo foi desenvolvida uma pesquisa bibliográfica em artigos e livros que tratam do tema sendo realizada uma conceituação dos aspectos genéricos da responsabilidade penal do produtor e, por fim, foram desenvolvidas as considerações que permitem fundamentar essa posição de garantia "especial ou específica" do órgão superior do meio empresarial naquela situação — introduzindo devidamente uma produto no mercado.
EFEITO DA PANDEMIA COVID-19 NA INDUSTRIA DA CONSTRUÇÃO CIVIL
Authors: Costa Vitória Tayrini Santos de Oliveira da
Published: November 2023

Em Wuhan na China no ano de 2019 teve início a pandemia do COVID-19, uma doença global que matou milhares de pessoas atingindo economicamente todos os países indistintamente e no Brasil não foi diferente, inúmeras foram as perdas e a retomada está sendo lenta e gradativa em todos os setores. Entre as perdas é preciso identificar que o setor da construção civil fui amplamente atingido, principalmente nos momentos em que foram decretados lockdown, pessoas colocadas em quarentena e realizando seus trabalhos em home Office. Algo preocupante, visto que o setor da construção civil é um dos mais importantes impulsionadores por meio de suas demandas interna e empregos gerados no país. O setor foi extremamente impactado pelas medidas restritivas de combate à pandemia e em 2020, registrou as piores taxas. Entretanto, alguns fatores como a criação de novos hospitais e clínicas, bem como o trabalho realizado em casa, de alguma forma contribuiu para que o setor da construção civil fosse o pioneiro na recuperação econômica e para entender melhor todo este processo, o Presente trabalho teve como objetivo discorrer sobre os principais elementos envolvidos neste processo, para tanto será relatado os principais problemas enfrentados durante o período pandémico os principais indicadores de crescimento e perspectivas do setor da construção civil, assim como o “boom” do setor e os elementos que vêm mantendo o setor aquecido e quais serão os desafios para o manter o crescimento e a expansão do setor.
Extrapyramidal Symptoms and Insulin Resistance in a Patient on Multiple Antipsychotics Therapy
Authors: Ahmed Rishad , Roy Devangana
Published: November 2023

Background/Objective: Multiple Antipsychotics Therapy promote obesity and insulin resistance. This study aimed to describe a T2DM patient with extrapyramidal symptoms and hyperglycemia who was also on several antipsychotic therapies and to determine whether omission of all antipsychotics along with modification of antidiabetic therapy led to better glycemic control.
Case Report: An uncontrolled T2DM female subject presented with tremor in both hands as well as in the right corner of her lips. She also having comorbid hypertension and hypothyroidism. On examination, she showed no signs of pallor, icterus, clubbing, cyanosis or edema. Central nervous system examination revealed a GCS of 15 and neurological examinations including motor and sensory responses were unremarkable in Nerve Conduction Study and MRI. her blood glucose levels showed poorly controlled diabetes (HbA1C – 9.5%, FBS – 278mg/dl, PPBS – 234mg/dl) in spite of taking OHAs. Her initial treatment plan included omission of all antipsychotics and reduction in dose of glimepiride to 4mg. This led to a drastic fall in the blood glucose levels. Her CBG levels were between 100mg/dl- 150 mg/dl. Soon after this, the dose of metformin was reduced to 1000mg, vildagliptin was omitted and a SGLT-2 inhibitor was added. This caused gradual improvement in her symptoms and subsequently the blood sugar levels and blood pressure were also within acceptable limits.
Discussion: Diabetes and hyperglycaemic emergencies are linked to APDs. There may be several processes that mediate this. In insulin-sensitive cells such muscle cells, hepatocytes, and adipocytes, APDs can block the insulin signalling pathway, resulting in insulin resistance. When choosing a course of treatment, one must consider this elevated risk.
Conclusion: Patients receiving multiple antipsychotics therapy are more likely to experience negative metabolic alterations. This case findings also highlight the importance of glycemic control in patients with acute or subacute onset movement disorders, irrespective of their past glycemic status.

Keywords: Multiple Antipsychotics Therapy, insulin resistance, T2DM patient, extrapyramidal symptoms, hyperglycemia.
The Development Strategy of Natural Skincare (Case Study PT Nectars Natura Karya)
Authors: Lubis Yazid Hilmi , Indrawan R. Dikky , . Rokhani
Published: November 2023

In recent years, skincare industry has grown rapidly in Indonesia. The growing number of skincare users in Indonesia becomes an opportunity for skincare producers in Indonesia, which is dominated by MSMEs. PT Nectars Natura Karya is one of MSMEs that consistently produce and promote the usage of natural skincare and sustainable products. Like other MSMEs, in particular, Covid-19 pandemic had impacted PT Nectars Natura Karya’s business as their sales dropped 30 percent in 2020. Based on those problems, PT Nectars Natura Karya needs to improve the resilience of their business in this post-Covid era. This research aims to identify strategic priorities for PT Nectars Natura Karya to compete with competitors and stay relevant in the market. In order to answer the research question, this research used the EFE and IFE Matrix to identify and evaluate external and internal factors. In the matching stage, external and internal factors were used to generate feasible alternative strategies for PT Nectars Natura Karya. In this stage, the author used IE and SWOT Matrix to formulate alternative strategies. To determine the best strategies for PT Nectars Natura Karya, the author used AHP and TOPSIS methods. The results explain implementing digital marketing and increasing their digital literacy is the best option for PT Nectars Natura Karya. Digital literacy has already become a “have-to-have” skill for SMEs since most of consumers interact and buy products through digital platforms.

Keywords: AHP, MSMEs, natural skincare, PT Nectars Natura Karya, TOPSIS
Pengembangan Media Buku Ajar Pencak Silat Berbasis Elektronik QR Code
Authors: Misno Misno , Daryanto Zusyah Porja , Cahyadi Ashadi
Published: November 2023

Tujuan penelitian ini adalah untuk mengembangkan media buku ajar pencak silat berbasis qr code. Metode yang digunakan dalam penelitian ini adalah metode penelitan dan pengembangan model ADDIE. Dengan pertimbangan: (1) dapat disesuaikan dengan hampir semua konteks pengembangan produk, termasuk buku pelajaran, (2) produk dapat terus ditingkatkan pada setiap tahap sehingga membuat buku teks yang lebih baik, (3) proses pengembangannya sederhana, sistematis dan praktis. Dari hasil evaluasi buku ajar pencak silat oleh ahli materi diperoleh persentase sebesar 95% dan 80% oleh ahli media pada dengan kategori sangat sangat baik dan baik. Berdasarkan hasil dari uji coba pada guru diperoleh persentase sebesar 99% dengan kategori sangat baik dan hasil dari uji coba pada siswa diperoleh persentase sebesar 99% dengan kategori sangat baik. Hasil Penelitian dapat disimpulkan bahawa dengan adanya media buku ajar mempermudah pembelajaran dikarenakan selain dengan gambar yang menarik juga dilengkapi teknologi terkini scan Qr Qode sehingga pengaplikasiannya lebih mudah dan praktis.
Marapu dan Penyelesaikan Kasus Sengketa Tanah di Kelurahan Mauliru Kabupaten Sumba Timur
Authors: Kalaway Jeztril u m , Kudubun Elly Esra , Purnomo Daru
Published: November 2023

Sengketa lahan saat ini tidak dapat dihindari karena tingginya kebutuhan akan tanah sementara jumlah bidang tanah terbatas. Penyelesaian sengketa tanah merupakan upaya penyelesaian sengketa tanah antara pihak-pihak yang merasa hak atas tanahnya di langgar Penelitian ini dilakukan di Kelurahan Mauliru Kabupaten Sumba Timur. Tujuan dari penelitian ini adalah untuk menjelaskan dan menganalisis konflik tanah adat di Kelurahan Mauliru.metode yang digunakan adalah metode kualitatif deskriptif konstruktivisme, hasil penelitian adalah bahwa kasus sengketa tanah Terjadi mula-mula akibat kedua belah pihak bentrok dengan batas tanah. Penyelesaian ini menggunakan tiga jenis teori konflik Ralf Dahdendrof yakni mediasi, konsiliasi, dan arbitrase. Konsiliasi dibawa atau dilaporkan langsung ke Badan Pertanahan Kabupaten Sumba Timur agar mendapatkan penyelesaian yang diinginkan Namun lembaga yang dituju tidak dapat menyelesaikan permasalahan yang timbul, oleh karena itu dihadirkan proses mediasi yaitu dilakukan dengan cara adat Marapu yang dimana proses mediasi tersebut dihadirkan kepala adat sebagai pihak penengah. Hasil dari mediasi terkait masalah konflik tanah, diperoleh kesepakatam kedua belah pihak melakukan penyelesaian secara kekeluargaan, dan hasilnya kasus konflik tanah dapat diselesaikan secara adat.
Pengaruh Struktur Kepemilikan terhadap Nilai Perusahaan dengan Profitabilitas sebagai Variabel Moderasi
Authors: Wangsa Arief Dharma
Published: November 2023

Tujuan penelitian ini adalah untuk memperoleh bukti empiris mengenai apakah kepemilikan manajerial, kepemilikan institusional, kepemilikan asing, kepemilikan publik dan kepemilikan terkonsentrasi memiliki pengaruh terhadap nilai perusahaan dengan profitabilitas sebagai variabel moderasi. Data penelitian ini terdiri dari 25 perusahaan sektor kesehatan yang terdaftar di Bursa Efek Indonesia selama tiga tahun dengan periode penelitian dari tahun 2020 sampai dengan tahun 2022. Sampel yang dipilih dengan menggunakan metode sampel total/jenuh. Metode analisis data dalam penelitian ini menggunakan metode hipotesis dengan regresi analisis moderasi. Hasil penelitian menunjukkan kepemilikan asing dan kepemilikan publik berpengaruh signifikan terhadap nilai perusahaan dengan arah positif. Sedangkan kepemilikan manajerial, kepemilikan institusional dan kepemilikan terkonsentrasi tidak berpengaruh signifikan terhadap nilai perusahaan. Profitabilitas tidak dapat memperlemah ataupun memperkuat pengaruh kepemilikan manajerial, kepemilikan institusional, kepemilikan asing dan kepemilikan publik terhadap nilai perusahaan.