bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Stigma Management in HIV Treatment Adherence
Authors: Rintamaki Lance , Kosenko Kami , Hogan Timothy , Scott Allison M. , Dobmeier Christopher , Tingue Erik , Peek David
Published: December 2019

Social stigma is linked to improper HIV treatment adherence, but how stigma impairs adherence outcomes is poorly understood. This study included 93 people living with HIV in the United States who participated in focus groups or one-on-one interviews regarding how stigma might affect medication management. Latent content analysis and constant comparative techniques of participant responses that were produced three thematic groupings that described how participants (a) orient to HIV stigma, (b) manage HIV stigma in ways that directly impair treatment adherence, and (c) manage HIV stigma in ways that may indirectly impair adherence. These findings illustrate the need to understand how patients orient to HIV stigma when prescribing medications and the complications that are inherent to such assessments. In addition, these findings provide a simple framework for organizing the different ways in which stigma management strategies may disrupt treatment adherence. Conceptually, these findings also offer a paradigm shift to extent theories on disclosure and concealment, in which only disclosure has been cast as an active process. These findings demonstrate how concealment is far from a passive default, often requiring enormous effort. Ultimately, these findings may guide intervention programs that help to entirely eliminate HIV by promoting optimized counseling and subsequent treatment adherence.
A Comparison of Flavorless Electronic Cigarette-Generated Aerosol and Conventional Cigarette Smoke on the Planktonic Growth of Common Oral Commensal Streptococci
Authors: Nelson John M. , Cuadra Giancarlo A. , Palazzolo Dominic L.
Published: December 2019

Background: Smoking is the number one predictor for the development of periodontal disease. Consequently, electronic cigarette (ECIG) use has prompted investigations into the health-related risks induced by ECIG-generated aerosol on oral commensal bacteria as compared to cigarette smoke. Since E-liquid contains fewer constituents than smoke, we hypothesize that growth media containing E-liquid or aerosol has less impact on oral commensal streptococci than cigarette smoke. Methods: Eight-hour growth curves were generated for three strains of streptococci following exposure of growth media to nicotine alone (0.05, 0.1, 0.2 mg/mL), E-liquid ± nicotine (2.3, 4.7, 7.0 µL/mL), ECIG-generated aerosol ± nicotine (25, 50, 75 puffs), or cigarette smoke (2, 5, 10, 25, 50, 75 puffs). Nicotine and E-liquid were added to the media at concentrations equivalent to vaporized amounts of 25, 50, or 75 puffs. Absorbance readings were taken at 0, 2, 4, 6, and 8 h of bacterial growth. Results: Both E-liquid and aerosol (±nicotine) had little to no effect on eight-hour streptococcal growth. In contrast, five puffs of smoke inhibited streptococcal growth. Conclusions: Smoke-treated growth media, but not E-liquid or ECIG-generated aerosol, inhibits the growth of oral commensal streptococci. A possible implication is that aerosol may induce less periodontitis than smoke.
Screening of Different Carbon Nanotubes in Melt-Mixed Polymer Composites with Different Polymer Matrices for Their Thermoelectrical Properties
Authors: Krause Beate , Barbier Carine , Levente Juhasz , Klaus Maxim , Pötschke Petra
Published: December 2019

The aim of this study is to reveal the influences of carbon nanotube (CNT) and polymer type as well as CNT content on electrical conductivity, Seebeck coefficient (S), and the resulting power factor (PF) and figure of merit (ZT). Different commercially available and laboratory made CNTs were used to prepare melt-mixed composites on a small scale. CNTs typically lead to p-type composites with positive S-values. This was found for the two types of multi-walled CNTs (MWCNT) whereby higher Seebeck coefficient in the corresponding buckypapers resulted in higher values also in the composites. Nitrogen doped MWCNTs resulted in negative S-values in the buckypapers as well as in the polymer composites. When using single-walled CNTs (SWCNTs) with a positive S-value in the buckypapers, positive (polypropylene (PP), polycarbonate (PC), poly (vinylidene fluoride) (PVDF), and poly(butylene terephthalate) (PBT)) or negative (polyamide 66 (PA66), polyamide 6 (PA6), partially aromatic polyamide (PARA), acrylonitrile butadiene styrene (ABS)) S-values were obtained depending on the matrix polymer and SWCNT type. The study shows that the direct production of n-type melt-mixed polymer composites from p-type commercial SWCNTs with relatively high Seebeck coefficients is possible. The highest Seebeck coefficients obtained in this study were 66.4 µV/K (PBT/7 wt % SWCNT Tuball) and −57.1 µV/K (ABS/0.5 wt % SWCNT Tuball) for p- and n-type composites, respectively. The highest power factor and ZT of 0.28 µW/m·K2 and 3.1 × 10−4, respectively, were achieved in PBT with 4 wt % SWCNT Tuball.
Electrophoretic Deposition of Quantum Dots and Characterisation of Composites
Authors: Purcell-Milton Finn , Curutchet Antton , Gun’ko Yurii
Published: December 2019

Electrophoretic deposition (EPD) is an emerging technique in nanomaterial-based device fabrication. Here, we report an in-depth study of this approach as a means to deposit colloidal quantum dots (CQDs), in a range of solvents. For the first time, we report the significant improvement of EPD performance via the use of dichloromethane (DCM) for deposition of CQDs, producing a corresponding CQD-TiO2 composite with a near 10-fold increase in quantum dot loading relative to more commonly used solvents such as chloroform or toluene. We propose this effect is due to the higher dielectric constant of the solvent relative to more commonly used and therefore the stronger effect of EPD in this medium, though there remains the possibility that changes in zeta potential may also play an important role. In addition, this solvent choice enables the true universality of QD EPD to be demonstrated, via the sensitization of porous TiO2 electrodes with a range of ligand capped CdSe QDs and a range of group II-VI CQDs including CdS, CdSe/CdS, CdS/CdSe and CdTe/CdSe, and group IV-VI PbS QDs.
Analysis of the Functionally Step-Variable Graded Plate Under In-Plane Compression
Authors: Czechowski Leszek , Kołakowski Zbigniew
Published: December 2019

A study of the pre- and post-buckling state of square plates built from functionally graded materials (FGMs) and pure ceramics is presented. In contrast to the theoretical approach, the structure under consideration contains a finite number of layers with a step-variable change in mechanical properties across the thickness. An influence of ceramics content on a wall and a number of finite layers of the step-variable FGM on the buckling and post-critical state was scrutinized. The problem was solved using the finite element method and the asymptotic nonlinear Koiter’s theory. The investigations were conducted for several boundary conditions and material distributions to assess the behavior of the plate and to compare critical forces and post-critical equilibrium paths.
Magnetic Nanoparticles Supporting Bio-responsive T1/T2 Magnetic Resonance Imaging
Authors: Ellis Connor M. , Pellico Juan , Davis Jason J.
Published: December 2019

The use of nanoparticulate systems as contrast agents for magnetic resonance imaging (MRI) is well-established and known to facilitate an enhanced image sensitivity within scans of a particular pathological region of interest. Such a capability can enable both a non-invasive diagnosis and the monitoring of disease progression/response to treatment. In this review, magnetic nanoparticles that exhibit a bio-responsive MR relaxivity are discussed, with pH-, enzyme-, biomolecular-, and protein-responsive systems considered. The ability of a contrast agent to respond to a biological stimulus provides not only enriched diagnostic capabilities over corresponding non-responsive analogues, but also an improved longitudinal monitoring of specific physiological conditions.
Ni/Si-Codoped TiO2 Nanostructure Photoanode for Enhanced Photoelectrochemical Water Splitting
Authors: Li Ting , Ding Dongyan
Published: December 2019

We synthesized Ni/Si-codoped TiO2 nanostructures for photoelectrochemical (PEC) water splitting, by electrochemical anodization of Ti-1Ni-5Si alloy foils in ethylene glycol/glycerol solutions containing a small amount of water. The effects of annealing temperature on PEC properties of Ni/Si-codoped TiO2 photoanode were investigated. We found that the Ni/Si-codoped TiO2 photoanode annealed at 700 °C had an anatase-rutile mixed phase and exhibited the highest photocurrent density of 1.15 mA/cm2 at 0 V (vs. Ag/AgCl), corresponding to a photoconversion efficiency of 0.70%, which was superior to Ni-doped and Si-doped TiO2. This improvement in PEC water splitting could be attributed to the extended light absorption, faster charge transfer, possibly lower charge recombination, and longer lifetime.
Response of Connections between Concrete Corbels and Safety Barriers
Authors: Cattaneo Sara , Crespi Pietro
Published: December 2019

Post-installed anchor systems are widely used in several applications both for retrofit and new constructions due to their flexibility and easiness of installation. For these reasons, their use is very common to connect safety barriers to concrete corbels. However, the design requirements for fastening (Eurocode 2—Part 4, ACI 318 or for post-installed rebar (Eurocode 2-Part 1 can be hardly satisfied due to the geometric restrictions of the application. Additional complications arise for the refurbishment of bridge corbels, which usually requires the removal of the damaged top concrete layer. This paper presents a new anchoring system that consists of the use of additional post-installed U-shaped rebars connecting the lower existing portion of the corbel to the upper (rebuilt) layer, able to carry the required design loads. The proposed solution considers three anchors that transfer the external loads to the corbel, to the existing reinforcements, and to the U-shaped rebars. The system is tested experimentally and validated by using both theoretical (strut and tie modeling) and numerical analyses.
Green Synthesis of Composite Graphene Aerogels with Robust Magnetism for Effective Water Remediation
Authors: Liu Qixia , Hu Shiqi , Yang Zhilian , Zhang Xueyan , Ge Jianlong
Published: December 2019

Graphene-based three-dimensional (3D) magnetic assemblies have attracted great research attention owing to their multiple natures inherited from 3D graphene assemblies and magnetic materials. However, at present, the practical applications of graphene-based magnetic materials are limited by the relative complex synthesis procedure and harsh operation conditions. Hence, a facile and green synthesis strategy is highly desired. Herein, a magnetic graphene aerogel with magnetite nanoparticles in-situ synthesized on the surface of its frameworks was fabricated through a green and facile strategy. The synthesis process was performed in a gentle condition with low energy consumption. The obtained graphene aerogels exhibited superior magnetism with a saturation magnetization of 55.7 emu·g−1. With the merits of well-developed pore structures, high surface area, and robust magnetic property, the obtained composite aerogels exhibited intriguing adsorption and photo-Fenton catalytic degradation performances for the organic dyes in water. Moreover, the utilized graphene aerogels could be recycled from the water due to their effective magnetic separation performance, indicating a promising capability for practical applications in the area of water remediation. We anticipate this synthesis strategy could provide some guidance for the design and development of 3D magnetic assemblies.
Photoactive Pore Matrix for In Situ Delivery of a Photosensitizer in Vascular Smooth Muscle Cells Selective PDT
Authors: Wawrzyńska Magdalena , Duda Maciej , Hołowacz Iwona , Kaczorowska Aleksandra , Ulatowska-Jarża Agnieszka , Buzalewicz Igor , Kałas Wojciech , Wysokińska Edyta , Biały Dariusz , Podbielska Halina , Kopaczyńska Marta
Published: December 2019

In this study we present the porous silica-based material that can be used for in situ drug delivery, offering effective supply of active compounds regardless its water solubility. To demonstrate usability of this new material, three silica-based materials with different pore size distribution as a matrix for doping with Photolon (Ph) and Protoporphyrin IX (PPIX) photosensitizers, were prepared. These matrices can be used for coating cardiovascular stents used for treatment of the coronary artery disease and enable intravascular photodynamic therapy (PDT), which can modulate the vascular response to injury caused by stent implantation—procedure that should be thought as an alternative for drug eluting stent. The FTIR spectroscopic analysis confirmed that all studied matrices have been successfully functionalized with the target photosensitizers. Atomic force microscopy revealed that resulting photoactive matrices were very smooth, which can limit the implantation damage and reduce the risk of restenosis. No viability loss of human peripheral blood lymphocytes and no erythrocyte hemolysis upon prolonged incubations on matrices indicated good biocompatibility of designed materials. The suitability of photoactive surfaces for PDT was tested in two cell lines relevant to stent implantation: vascular endothelial cells (HUVECs) and vascular smooth muscle cells (VSMC). It was demonstrated that 2 h incubation on the silica matrices was sufficient for uptake of the encapsulated photosensitizers. Moreover, the amount of the absorbed photosensitizer was sufficient for induction of a phototoxic reaction as shown by a rise of the reactive oxygen species in photosensitized VSMC. On the other hand, limited reactive oxygen species (ROS) induction in HUVECs in our experimental set up suggests that the proposed method of PDT may be less harmful for the endothelial cells and may decrease a risk of the restenosis. Presented data clearly demonstrate that porous silica-based matrices are capable of in situ delivery of photosensitizer for PDT of VSMC.
High-Cycle, Low-Cycle, Extremely Low-Cycle Fatigue and Monotonic Fracture Behaviors of Low-Carbon Steel and Its Welded Joint
Authors: Kim Younghune , Hwang Woonbong
Published: December 2019

Low-carbon steels are commonly used in welded steel structures and are exposed to various fatigue conditions, depending on the application. We demonstrate that the various transitions in the fracture mode during fatigue testing can be distinguished by their different cyclic response curves and microstructural features after fracture. Fractography, surface damage micrographs, and microstructural evolution clearly indicated the transition of the fracture modes from high-cycle to low-cycle, extremely low-cycle fatigue, and monotonic behavior. The high-cycle fatigue mode showed initial cyclic softening, followed by cyclic stabilization, and showed inclusion-induced crack initiation at fish-eyes, while the low-cycle fatigue mode showed initial cyclic hardening followed by cyclic stabilization, where fractography images showed obvious striations. In addition, the extremely low-cycle fatigue mode showed no cyclic stabilization after initial cyclic hardening, which was characterized by quasi-cleavage fractures with a few micro-dimples and transgranular cracking, while the monotonic fracture mode predominantly showed micro-dimples.
Biocompatibility of Root Canal Sealers: A Systematic Review of In Vitro and In Vivo Studies
Authors: Fonseca Diogo Afonso , Paula Anabela Baptista , Marto Carlos Miguel , Coelho Ana , Paulo Siri , Martinho José Pedro , Carrilho Eunice , Ferreira Manuel Marques
Published: December 2019

(1) Aim: To perform a systematic review of the literature on the biocompatibility of root canal sealers that encompasses the various types of sealers that are commercially available as well as both in vitro and in vivo evidence. (2) Methods: This systematic review has been registered in PROSPERO (ID 140445) and was carried out according to PRISMA guidelines using the following databases: PubMed, Cochrane Library, ClinicalTrials.gov, Science Direct, and Web of Science Core Collection. Studies published between 2000 and 11 June 2019 that evaluated cytotoxicity (cell viability/proliferation) and biocompatibility (tissue response) of root canal sealers were included. (3) Results: From a total of 1249 studies, 73 in vitro and 21 in vivo studies were included. In general, studies suggest that root canal sealers elicit mild to severe toxic effects and that several factors may influence biocompatibility, e.g., material setting condition and time, material concentration, and type of exposure. Bioactive endodontic sealers seem to exhibit a lower toxic potential in vitro. (4) Conclusions: The available evidence shows that root canal sealers exhibit variable toxic potential at the cellular and tissue level. However, the methodological heterogeneity among studies included in this systematic review and the somewhat conflicting results do not allow a conclusion on which type of sealer presents higher biocompatibility. Further research is crucial to achieve a better understanding of the biological effects of root canal sealers.
Preparation of Porous Ceramsite with Ammonium Acetate as Low-Temperature Decomposition Foaming Agent and Its Sound Absorption Performance
Authors: Wu Huiqin , Huang Huansheng , Pan Rongjun , Chun Yeyang , Zhu Ling , Nong Kailun
Published: December 2019

The sound absorption performance of porous ceramisite is determined by its pore structure, which is mainly governed by a foaming agent and heating rate during a foaming process. By tuning the heating rate and foaming agent concentration, ceramisite with different pore structures was prepared by using flyash, cement, quick lime, and plaster as raw materials as well as ammonium acetate as a low-temperature decomposition foaming agent in this work. The phase composition, microstructure, and sound absorption performance of the prepared porous ceramisite were investigated. Results demonstrate that the apparent porosity and the pore diameter increased with the increase of foaming agent concentration, accompanied with the broadening of the pore diameter distribution. The apparent porosity is positively correlated with heating rate until the temperature is higher than 20 °C·min−1, while the pore diameter is negatively correlated. The pore diameter distribution becomes narrow as a function of the heating rate. The sound absorption performance is positively correlated with the apparent porosity. An optimal pore diameter might exist, meaning diameter sizes that are larger or smaller than the optimal diameter are not conducive to the optimization of the sound absorption performance of the overall frequency band. It was determined that the curing time was not a key factor for optimizing the pore structure.
Finite Integration Method with Shifted Chebyshev Polynomials for Solving Time-Fractional Burgers’ Equations
Authors: Duangpan Ampol , Boonklurb Ratinan , Treeyaprasert Tawikan
Published: December 2019

The Burgers’ equation is one of the nonlinear partial differential equations that has been studied by many researchers, especially, in terms of the fractional derivatives. In this article, the numerical algorithms are invented to obtain the approximate solutions of time-fractional Burgers’ equations both in one and two dimensions as well as time-fractional coupled Burgers’ equations which their fractional derivatives are described in the Caputo sense. These proposed algorithms are constructed by applying the finite integration method combined with the shifted Chebyshev polynomials to deal the spatial discretizations and further using the forward difference quotient to handle the temporal discretizations. Moreover, numerical examples demonstrate the ability of the proposed method to produce the decent approximate solutions in terms of accuracy. The rate of convergence and computational cost for each example are also presented.
A Backward Technique for Demographic Noise in Biological Ordinary Differential Equation Models
Authors: Carletti Margherita , Banerjee Malay
Published: December 2019

Physical systems described by deterministic differential equations represent idealized situations since they ignore stochastic effects. In the context of biomathematical modeling, we distinguish between environmental or extrinsic noise and demographic or intrinsic noise, for which it is assumed that the variation over time is due to demographic variation of two or more interacting populations (birth, death, immigration, and emigration). The modeling and simulation of demographic noise as a stochastic process affecting units of populations involved in the model is well known in the literature, resulting in discrete stochastic systems or, when the population sizes are large, in continuous stochastic ordinary differential equations and, if noise is ignored, in continuous ordinary differential equation models. The inverse process, i.e., inferring the effects of demographic noise on a natural system described by a set of ordinary differential equations, is still an issue to be addressed. With this paper, we provide a technique to model and simulate demographic noise going backward from a deterministic continuous differential system to its underlying discrete stochastic process, based on the framework of chemical kinetics, since demographic noise is nothing but the biological or ecological counterpart of intrinsic noise in genetic regulation. Our method can, thus, be applied to ordinary differential systems describing any kind of phenomena when intrinsic noise is of interest.
On the Betti and Tachibana Numbers of Compact Einstein Manifolds
Authors: Rovenski Vladimir , Stepanov Sergey , Tsyganok Irina
Published: December 2019

Throughout the history of the study of Einstein manifolds, researchers have sought relationships between the curvature and topology of such manifolds. In this paper, first, we prove that a compact Einstein manifold ( M , g ) with an Einstein constant α > 0 is a homological sphere when the minimum of its sectional curvatures > α / ( n + 2 ) ; in particular, ( M , g ) is a spherical space form when the minimum of its sectional curvatures > α / n . Second, we prove two propositions (similar to the above ones) for Tachibana numbers of a compact Einstein manifold with α < 0 .
Ethyl Rosmarinate Prevents the Impairment of Vascular Function and Morphological Changes in L-NAME-Induced Hypertensive Rats
Authors: Pantan Rungusa , Tocharus Jiraporn , Nakaew Archawin , Suksamrarn Apichart , Tocharus Chainarong
Published: December 2019

Background and Objectives: The potent, endothelium-independent, vasorelaxant effect of ethyl rosmarinate, an ester derivative of rosmarinic acid, makes it of interest as an alternative therapeutic agent for use in hypertension. This study was designed to investigate the effect of ethyl rosmarinate on Nω-nitro-L-arginine methyl ester (L-NAME)-induced hypertensive rats. Materials and Methods: L-NAME was given orally to male Wistar rats for 6 weeks to induce hypertension concurrently with treatment of ethyl rosmarinate at 5, 15, or 30 mg/kgor enalapril at 10 mg/kg Systolic blood pressure (SBP), heart rate, and body weight of all experimental groups were recorded weekly, while the vascular sensitivity and histological changes of the aorta were evaluated at the end of the experiment. Results: For all treatment groups, the data indicated that ethyl rosmarinate significantly attenuated the SBP in hypertensive rats induced by L-NAME, with no significant differences in heart rate and body weight. In addition, the response of vascular sensitivity to acetylcholine (ACh) was improved but there was no significant difference in the response to sodium nitroprusside (SNP). Furthermore, the sensitivity of the aorta to phenylephrine (PE) was significantly decreased. The thickness of the aortic wall did not differ between groups but the expression of endothelial nitric oxide synthase (eNOS) was increased in ethyl rosmarinate- and enalapril-treated groups compared with the hypertensive group. Conclusions: Ethyl rosmarinate is an interesting candidate as an alternative treatment for hypertension due to its ability to improve vascular function and to increase the expression of eNOS similar to enalapril which is a drug commonly used in hypertension.
Comparative Spectrographic Analysis of the Newborns’ Cry in the Presence of Tight Intrapartum Nuchal Cord vs. Normal Using the Neonat App. Preliminary Results
Authors: Enatescu Ileana , Gluhovschi Adrian , Nyiredi Alexandra , Iacob Emil-Radu , Iacob Daniela , Dima Mirabela A. , Popescu Manuela M. , Enatescu Virgil-Radu
Published: December 2019

Background and objectives: The objective of this study was to contribute to the evaluation of the newborn (NB) cry as a means of communication and diagnosis. Materials and Methods: The study implied the recording of the spontaneous cry of 101 NBs with no intrapartum events (control sample), and of 72 NBs with nuchal cord (study sample) from the “Bega” University Clinic of Obstetrics–Gynecology and Neonatology of Timisoara, Romania. The sound analysis was based upon: Imagistic highlighting methods, descriptive statistics, and data mining techniques. Results: The differences between the cry of NBs with no intrapartum events and that of NBs affected by nuchal cord are statistically significant regarding the volume unit meter (VUM) (p = 0.0021) and the peak point meter (PPM) (p = 0.041). Conclusions: While clinically there are no differences between the two groups, the cry recorded from the study group (nuchal cord group) shows distinctive characteristics compared to the cry recorded from the control group (eventless intrapartum NBs group).
Effect of Heat Input on Weld Formation and Tensile Properties in Keyhole Mode TIG Welding Process
Authors: Fei Zhenyu , Pan Zengxi , Cuiuri Dominic , Li Huijun , Wu Bintao , Ding Donghong , Su Lihong
Published: December 2019

Keyhole mode Tungsten Inert Gas (K-TIG) welding is a novel advanced deep penetration welding technology which provides an alternative to high power density welding in terms of achieving keyhole mode welding. In order to facilitate welding procedure optimisation in this newly developed welding technology, the relationship among welding parameters, weld formation and tensile properties during the K-TIG welding was investigated in detail. Results show that except for travel speed, the heat input level also plays an important role in forming undercut defect by changing the plasma jet trajectory inside keyhole channel, leading to the formation of hump in the weld centre and exacerbation of undercut formation. Both undercut defect and root side fusion boundary can act as a stress concentration point, which affects the fracture mode and tensile properties considerably. The research results provide a practical guidance of process parameter optimisation and quality assurance for the K-TIG welding process.
A Compound Control Based on the Piezo-Actuated Stage with Bouc–Wen Model
Authors: Fang Jiwen , Wang Jia , Li Chong , Zhong Wei , Long Zhili
Published: December 2019

The piezoelectric actuator (PA) is one of the most commonly used actuators in a micro-positioning stage. But its hysteresis non-linearity can cause error in the piezo-actuated stage. A modified Bouc–Wen model is presented in this paper to describe the hysteresis non-linearity of the piezo-actuated stage. This model can be divided into two categories according to the input frequency: rate-independent type and rate-dependent type. A particle swarm optimization method (PSO) is employed to identify these parameters of the Bouc–Wen hysteresis model. An inverse model feedforward compensator is established based on the modified Bouc–Wen model. The fuzzy proportional-integral-derivative (PID) controller combined with the feedforward compensator is implemented to the piezo-actuated stage. The experimental results indicate that the proposed control strategy can compensate for the hysteresis phenomenon.
Design and Fabrication of Flexible Naked-Eye 3D Display Film Element Based on Microstructure
Authors: Cao Axiu , Xue Li , Pang Yingfei , Liu Liwei , Pang Hui , Shi Lifang , Deng Qiling
Published: December 2019

The naked-eye three-dimensional (3D) display technology without wearing equipment is an inevitable future development trend. In this paper, the design and fabrication of a flexible naked-eye 3D display film element based on a microstructure have been proposed to achieve a high-resolution 3D display effect. The film element consists of two sets of key microstructures, namely, a microimage array (MIA) and microlens array (MLA). By establishing the basic structural model, the matching relationship between the two groups of microstructures has been studied. Based on 3D graphics software, a 3D object information acquisition model has been proposed to achieve a high-resolution MIA from different viewpoints, recording without crosstalk. In addition, lithography technology has been used to realize the fabrications of the MLA and MIA. Based on nanoimprint technology, a complete integration technology on a flexible film substrate has been formed. Finally, a flexible 3D display film element has been fabricated, which has a light weight and can be curled.
Evaluating the Role of Iron-Rich (Mg,Fe)O in Ultralow Velocity Zones
Authors: Dobrosavljevic Vasilije V. , Sturhahn Wolfgang , Jackson Jennifer M.
Published: December 2019

The composition of ultralow velocity zones (ULVZs) remains an open question, despite advances in both seismology and experimental work. We investigate the hypothesis of iron-rich (Mg,Fe)O (magnesiowüstite) as a cause of ULVZ seismic signatures. We report new quasi-hydrostatic X-ray diffraction measurements to constrain the equation of state of (Mg0.06Fe0.94)O with fit parameters V0 = 9.860 ± 0.007 Å3, K0T = 155.3 ± 2.2 GPa, K’0T = 3.79 ± 0.11, as well as synchrotron Mössbauer spectroscopy measurements to characterize the high-pressure magnetic and spin state of magnesiowüstite. We combine these results with information from previous studies to calculate the elastic behavior at core–mantle boundary conditions of magnesiowüstite, as well as coexisting bridgmanite and calcium silicate perovskite. Forward models of aggregate elastic properties are computed, and from these, we construct an inverse model to determine the proportions of magnesiowüstite that best reproduce ULVZ observations within estimated mutual uncertainties. We find that the presence of magnesiowüstite can explain ULVZ observations exhibiting 1:2 VP:VS reduction ratios relative to the Preliminary Reference Earth Model (PREM), as well as certain 1:3 VP:VS reductions within estimated uncertainty bounds. Our work quantifies the viability of compositionally distinct ULVZs containing magnesiowüstite and contributes to developing a framework for a methodical approach to evaluating ULVZ hypotheses.
Mg-Rich Authigenic Carbonates in Coastal Facies of the Vtoroe Zasechnoe Lake (Southwest Siberia): First Assessment and Possible Mechanisms of Formation
Authors: Novoselov Andrey , Konstantinov Alexandr , Lim Artem , Goetschl Katja , Loiko Sergey , Mavromatis Vasileios , Pokrovsky Oleg
Published: December 2019

The formation of Mg-rich carbonates in continental lakes throughout the world is highly relevant to irreversible CO2 sequestration and the reconstruction of paleo-sedimentary environments. Here, preliminary results on Mg-rich carbonate formation at the coastal zone of Lake Vtoroe Zasechnoe, representing the Setovskiye group of water bodies located in the forest-steppe zone of Southwest Western Siberia, are reported. The Setovskiye lakes are Cl−–Na+–(SO42−) type, alkaline, and medium or highly saline. The results of microscopic and mineralogical studies of microbialites from shallow coastal waters of Lake Vtoroe Zasechnoe demonstrated that Mg in the studied lake was precipitated in the form of hydrous Mg carbonates, which occur as radially divergent crystals that form clusters in a dumbbell or star shape. It is possible that hydrous Mg carbonate forms due to the mineralization of exopolymeric substances (EPS) around bacterial cells within the algal mats. Therefore, the Vtoroe Zasechnoe Lake represents a rare case of Mg-carbonates formation under contemporary lacustrine conditions. Further research on this, as well as other lakes of Setovskiye group, is needed for a better understanding of the possible role of biomineralization and abiotic mechanisms, such as winter freezing and solute concentration, in the formation of authigenic Mg carbonate in modern aquatic environments.
An Autophagy Inducing Triterpene Saponin Derived from Aster koraiensis
Authors: Kwon Jaeyoung , Ko Keebeom , Zhang Lijun , Zhao Dong , Yang Hyun Ok , Kwon Hak Cheol
Published: December 2019

Autophagy is an important self-degradative mechanism that plays a key role in treating neurodegeneration diseases. This research aimed at discovering bioactive compounds from Aster koraiensis. A new triterpene saponin, astersaponin I (1), was isolated from the EtOH extract of A. koraiensis. The structure of 1 was characterized by spectroscopic methods, ECD calculation, and acid hydrolysis. The biochemical analysis showed that compound 1 significantly increased the expression of microtubule-associated protein 1A/1B light chain 3B (LC3-II) expression in SH-SY5Y cells, which indicates the induction of autophagy. Thus, further study may be needed to clarify whether compound 1 exerts beneficial effects on neurodegeneration diseases like Parkinson’s disease through autophagy induction.
Review of Ginseng Anti-Diabetic Studies
Authors: Chen Wei , Balan Prabhu , Popovich David G.
Published: December 2019

Ginseng is one of the most valuable and commonly used Chinese medicines not only in ancient China but also worldwide. Ginsenosides, also known as saponins or triterpenoids, are thought to be responsible for the beneficial effects of ginseng. In this review, we summarize recent publications on anti-diabetic studies of ginseng extracts and ginsenosides in cells, animals, and humans. It seems that the anti-diabetic effect of ginseng is positive for type 2 diabetic patients but has no significant impact on prediabetes or healthy adults. Regulation of insulin secretion, glucose uptake, anti-oxidative stress, and anti-inflammatory pathways may be the mechanisms involved with ginseng’s anti-diabetic effects. Taken together, this summary provides evidence for the anti-diabetes effects of ginseng extracts and ginsenosides as well as the underlying mechanisms of their impact on diabetes.
Dendrimers as Soft Nanomaterials for Electrochemical Immunosensors
Authors: Sánchez Alfredo , Villalonga Anabel , Martínez-García Gonzalo , Parrado Concepción , Villalonga Reynaldo
Published: December 2019

Electrochemical immunosensors are antibody-based affinity biosensors with a high impact on clinical, environmental, food, and pharmaceutical analysis. In general, the analytical performance of these devices is critically determined by the materials and reagents used for their construction, signal production and amplification. Dendrimers are monodisperse and highly branched polymers with three-dimensional structures widely employed as “soft” nanomaterials in electrochemical immunosensor technology. This review provides an overview on the state-of-the-art in dendrimer-based electrochemical immunosensors, focusing on those using polyamidoamine and poly (propylene imine) dendrimers. Special emphasis is given to the most original methods recently reported for the construction of immunosensor architectures incorporating dendrimers, as well as to novel sensing approaches based on dendrimer-assisted signal enhancement strategies.
Effectiveness of Calcium Phosphate Desensitising Agents in Dental Hypersensitivity Over 24 Weeks of Clinical Evaluation
Authors: Usai Paolo , Campanella Vincenzo , Sotgiu Giovanni , Spano Giovanni , Pinna Roberto , Eramo Stefano , Saderi Laura , Garcia-Godoy Franklin , Derchi Giacomo , Mastandrea Giorgio , Milia Egle
Published: December 2019

Background: Calcium phosphate-based compounds are used to treat dental hypersensitivity (DH). Their long-term clinical behaviour needs further research. This study compared the 24-week effectiveness of Teethmate Desensitizer (TD), a pure tetracalcium phosphate (TTCP) and dicalcium phosphate dihydrate (DCPD) powder/water, to that of Dentin Desensitizer (DD), and Bite & White ExSense (BWE), both of calcium phosphate crystallites. Methods: A total of 105 subjects were selected. A random table was utilised to form three groups of 35 subjects. DH was evaluated using the evaporative sensitivity, tactile sensitivity tests, and the visual analogue scale (VAS) of pain. Response was recorded before the application of the materials (Pre-1), immediately after (Post-0), at 1 week (Post-1), 4 weeks (Post-2), 12 weeks (Post-3) and 24 weeks (Post-4). The non-parametric distribution was assessed with the Shapiro–Wilk statistical test. Intra-group differences for the six time points were evaluated with the Friedman statistical test and the Kruskal–Wallis test. Results: All the materials decreased DH after 24 weeks in comparison to Pre-1. However, the TTCP/DCPD cement showed the greatest statistical efficiency. Conclusions: The significant decrease of VAS scores produced by TD in the long term suggest the material as the most reliable in the clinical relief of DH.
Sex- and Age-Related Differences in the Contribution of Ultrasound-Measured Visceral and Subcutaneous Abdominal Fat to Fatty Liver Index in Overweight and Obese Caucasian Adults
Authors: Leone Alessandro , Battezzati Alberto , Bedogni Giorgio , Vignati Laila , Vanzulli Angelo , De Amicis Ramona , Foppiani Andrea , Bertoli Simona
Published: December 2019

Differences in body fat distribution may be a reason for the sex-, age-, and ethnicity-related differences in the prevalence of fatty liver disease (FL). This study aimed to evaluate the sex- and age-related differences in the contribution of visceral (VAT) and subcutaneous (SAT) abdominal fat, measured by ultrasound, to fatty liver index (FLI) in a large sample of overweight and obese Caucasian adults, and to identify the VAT and SAT cut-off values predictive of high FL risk. A cross-sectional study on 8103 subjects was conducted. Anthropometrical measurements were taken and biochemical parameters measured. VAT and SAT were measured by ultrasonography. FLI was higher in men and increased with increasing age, VAT, and SAT. The sex*VAT, age*VAT, sex*SAT, and age*SAT interactions negatively contributed to FLI, indicating a lower VAT and SAT contribution to FLI in men and in the elderly for every 1 cm of increment. Because of this, sex- and age-specific cut-off values for VAT and SAT were estimated. In conclusion, abdominal adipose tissue depots are associated with FLI, but their contribution is sex- and age-dependent. Sex- and age-specific cut-off values of ultrasound-measured VAT and SAT are suggested, but they need to be validated in external populations.
A Novel Hybrid Additive Manufacturing Process for Drug Delivery Systems with Locally Incorporated Drug Depots
Authors: Konasch Jan , Riess Alexander , Mau Robert , Teske Michael , Rekowska Natalia , Eickner Thomas , Grabow Niels , Seitz Hermann
Published: December 2019

Here, we present a new hybrid additive manufacturing (AM) process to create drug delivery systems (DDSs) with selectively incorporated drug depots. The matrix of a DDS was generated by stereolithography (SLA), whereas the drug depots were loaded using inkjet printing. The novel AM process combining SLA with inkjet printing was successfully implemented in an existing SLA test setup. In the first studies, poly(ethylene glycol) diacrylate-based specimens with integrated depots were generated. As test liquids, blue and pink ink solutions were used. Furthermore, bovine serum albumin labeled with Coomassie blue dye as a model drug was successfully placed in a depot inside a DDS. The new hybrid AM process makes it possible to place several drugs independently of each other within the matrix. This allows adjustment of the release profiles of the drugs depending on the size as well as the position of the depots in the DDS.
Risperidone-Loaded PLGA–Lipid Particles with Improved Release Kinetics: Manufacturing and Detailed Characterization by Electron Microscopy and Nano-CT
Authors: Janich Christopher , Friedmann Andrea , Martins de Souza e Silva Juliana , Santos de Oliveira Cristine , Souza Ligia E. de , Rujescu Dan , Hildebrandt Christian , Beck-Broichsitter Moritz , Schmelzer Christian E. H. , Mäder Karsten
Published: December 2019

For parenteral controlled drug release, the desired zero order release profile with no lag time is often difficult to achieve. To overcome the undesired lag time of the current commercial risperidone controlled release formulation, we developed PLGA–lipid microcapsules (MCs) and PLGA–lipid microgels (MGs). The lipid phase was composed of middle chain triglycerides (MCT) or isopropylmyristate (IPM). Hydroxystearic acid was used as an oleogelator. The three-dimensional inner structure of Risperidone-loaded MCs and MGs was assessed by using the invasive method of electron microscopy with focused ion beam cutting (FIB-SEM) and the noninvasive method of high-resolution nanoscale X-ray computed tomography (nano-CT). FIB-SEM and nano-CT measurements revealed the presence of highly dispersed spherical structures around two micrometres in size. Drug release kinetics did strongly depend on the used lipid phase and the presence or absence of hydroxystearic acid. We achieved a nearly zero order release without a lag time over 60 days with the MC-MCT formulation. In conclusion, the developed lipid-PLGA microparticles are attractive alternatives to pure PLGA-based particles. The advantages include improved release profiles, which can be easily tuned by the lipid composition.
Evaluation of GPM-era Global Satellite Precipitation Products over Multiple Complex Terrain Regions
Authors: Derin Yagmur , Anagnostou Emmanouil , Berne Alexis , Borga Marco , Boudevillain Brice , Buytaert Wouter , Chang Che-Hao , Chen Haonan , Delrieu Guy , Hsu Yung , Lavado-Casimiro Waldo , Manz Bastian , Moges Semu , Nikolopoulos Efthymios , Sahlu Dejene , Salerno Franco , Rodríguez-Sánchez Juan-Pablo , Vergara Humberto , Yilmaz Koray
Published: December 2019

The great success of the Tropical Rainfall Measuring Mission (TRMM) and its successor Global Precipitation Measurement (GPM) has accelerated the development of global high-resolution satellite-based precipitation products (SPP). However, the quantitative accuracy of SPPs has to be evaluated before using these datasets in water resource applications. This study evaluates the following GPM-era and TRMM-era SPPs based on two years (2014–2015) of reference daily precipitation data from rain gauge networks in ten mountainous regions: Integrated Multi-SatellitE Retrievals for GPM (IMERG, version 05B and version 06B), National Oceanic and Atmospheric Administration (NOAA)/Climate Prediction Center Morphing Method (CMORPH), Global Satellite Mapping of Precipitation (GSMaP), and Multi-Source Weighted-Ensemble Precipitation (MSWEP), which represents a global precipitation data-blending product. The evaluation is performed at daily and annual temporal scales, and at 0.1 deg grid resolution. It is shown that GSMaPV07 surpass the performance of IMERGV06B Final for almost all regions in terms of systematic and random error metrics. The new orographic rainfall classification in the GSMaPV07 algorithm is able to improve the detection of orographic rainfall, the rainfall amounts, and error metrics. Moreover, IMERGV05B showed significantly better performance, capturing the lighter and heavier precipitation values compared to IMERGV06B for almost all regions due to changes conducted to the morphing, where motion vectors are derived using total column water vapor for IMERGV06B.
Improved Faraday Rotation Estimation in Spaceborne PolSAR Data Using Total Variation Denoising
Authors: Guo Wulong , Liu Lu , Liu Bo , Chen Liang , Zhao Haisheng , Wang Cheng
Published: December 2019

Faraday rotation (FR) is a serious problem for spaceborne polarization SAR (PolSAR) systems at L and P bands. One way to solve the problem is to estimate the FR from PolSAR data for further compensation. Therefore, precise estimation of FR from PolSAR data not only determines the compensation effect of polarimetric systems but also benefits the ionospheric sounding with high spatial resolution. Among the factors that affect the FR estimation, system noise is a non-neglectable factor. Although average filtering (AF) has been widely used in previous works for noise removing it depends on large window size, and therefore reduces the spatial resolution of FR estimation. In order to realize optimal noise suppression with minimized resolution loss, the total variation (TV) denoising method is applied in this paper. By testing the Advanced Land Observing Satellite (ALOS) Phased Array L-band Synthetic Aperture Radar (PALSAR) full-pol datasets, TV and AF are compared and validated. Results using synthetic and real data show that, after TV denoising, the FR can be recovered with high spatial resolution and the noise level in estimated FR is reduced more effectively than that after AF.
Comparison of Aqua/Terra MODIS and Himawari-8 Satellite Data on Cloud Mask and Cloud Type Classification Using Split Window Algorithm
Authors: Purbantoro Babag , Aminuddin Jamrud , Manago Naohiro , Toyoshima Koichi , Lagrosas Nofel , Sumantyo Josaphat Tetuko Sri , Kuze Hiroaki
Published: December 2019

Cloud classification is not only important for weather forecasts, but also for radiation budget studies. Although cloud mask and classification procedures have been proposed for Himawari-8 Advanced Himawari Imager (AHI), their applicability is still limited to daytime imagery. The split window algorithm (SWA), which is a mature algorithm that has long been exploited in the cloud analysis of satellite images, is based on the scatter diagram between the brightness temperature (BT) and BT difference (BTD). The purpose of this research is to examine the usefulness of the SWA for the cloud classification of both daytime and nighttime images from AHI. We apply SWA also to the image data from Moderate Resolution Imaging Spectroradiometer (MODIS) onboard Aqua and Terra to highlight the capability of AHI. We implement the cloud analysis around Japan by employing band 3 (0.469 μm) of MODIS and band 1 (0.47 μm) of AHI for extracting the cloud-covered regions in daytime. In the nighttime case, the bands that are centered at 3.9, 11, 12, and 13 µm are utilized for both MODIS and Himawari-8, with somewhat different combinations for land and sea areas. Thus, different thresholds are used for analyzing summer and winter images. Optimum values for BT and BTD thresholds are determined for the band pairs of band 31 (11.03 µm) and 32 (12.02 µm) of MODIS (SWA31-32) and band 13 (10.4 µm) and 15 (12.4 µm) of AHI (SWA13-15) in the implementation of SWA. The resulting cloud mask and classification are verified while using MODIS standard product (MYD35) and Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) data. It is found that MODIS and AHI results both capture the essential characteristics of clouds reasonably well in spite of the relatively simple scheme of SWA based on four threshold values, although a broader spread of BTD obtained with Himawari-8 AHI (SWA13-15) could possibly lead to more consistent results for cloud-type classification than SWA31-32 based on the MODIS sensors.