bluuebunny/crossref_metadata_2025 huggingface dataset:
Distribution of vaccine-related high-risk human papillomaviruses and their impact on the development of cervical dysplasia in women in Montenegro
Authors: Lopicic Milena , Raonic Janja , Antunovic Marija , Milicic Biljana , Mijovic Gordana
Published: November 2021

Cervical cancer (CC) is the third leading cause of death in women in Montenegro. Human papillomavirus (HPV) is the causative agent of CC however, HPV genotype distribution varies across regions. This study examined the distribution and impact of vaccine-related high-risk (HR)-HPVs on the development of cervical dysplasia in Montenegrin women. A total of 187 women who had a clinical indication for cervical biopsy were enrolled. Based on histopathological findings, women were classified into 2 groups, with and without dysplasia. HR-HPV was detected by real-time PCR. Twelve HR-HPV genotypes were detected in 40.6% of cervical samples. The 7 most prevalent HR-HPVs in order of decreasing frequency were HPV 16 (39.5%), 45 (23.7%), 31 (21.0%), 33 (17.1%), 18 (6.6%), 52 (6.6%), and 58 (6.6%), all of them are targeted by nonavalent vaccine. Vaccine-related HR-HPVs had a higher prevalence (92.1%) than the other HR-HPVs detected in HR-HPV–positive samples. Among HR-HPV–positive women, HPV 16 and 33 were more common in women with dysplasia than in those without dysplasia (HPV 16: 28.9 vs 7.2%; HPV 33: 11.8 vs 3.6%). HPV 16 was the most common HR-HPV genotype in cervical samples, followed by HPV 45, 31, 33, 18, 52, and 58. HPV 16 and 33 were shown to be associated with the development of cervical dysplasia. These results indicate that prophylactic nonavalent vaccine can potentially prevent approximately 90% of HR-HPV infections and 60% of cervical dysplasia cases in Montenegrin women.
“O político” na teologia de Paul Tillich
Authors: Taylor. Tradução Frederico Pieper Mark Lewis
Published: November 2021

A teologia de Paul Tillich apresenta a noção ampla de “o político”, que agora tem sido discutida por pensadores políticos dentro e fora da teologia. Ele pode estabelecer diálogo com pensadores tais como Giorgio Agamben, Chantal Mouffe, Clayton Crockett, Sylvia Wynter e Vincent Lloyd. Todo o corpus teológico de Tillich tem uma dimensão política recorrente, fundamental e vibrante. Isso não se deve apenas às questões políticas óbvias levantadas em seus primeiros escritos políticos alemães, como em seu livro de 1933, A decisão socialista (DS). Mais importante, suas palestras em Berlim de 1951, proferidas quando ele também publicou o primeiro volume de sua Teologia Sistemática (TS), mostram temas-chave que continuariam por toda a sua obra, até mesmo no volume 3 de sua TS. Consequentemente, a TS de Tillich pode ser lida como uma simbologia do político, uma “teopoética” da vida política - uma “teopoética” que faz parte de uma “política socialista” complexamente estruturada, uma postura que Tillich desenvolveu ao longo de anos de escrita até o fim de sua vida, bem como adaptou às mudanças políticas e aos conflitos culturais.
An Overview of the Documents of the Archive of Kaunas Benedictine Convent
Authors: Vasiliauskaite Ausra
Published: November 2021

In 2024, Kaunas Benedictine Convent will celebrate its 400th anniversary. Throughout this period, the convent’s existence has not been interrupted. During the Soviet period, from 1948 to 1988, the convent still operated in secret. However, the archives of the convent began to be organized anew at the beginning of the 21st century revealing important documentation not only for the convent, but also for monastic research. It is for this reason that this article aims to present the documents of Kaunas Benedictine Convent’s archive.
Beneficial Effects of Exercise on Cancer-Related Cognitive Impairment with Breast Cancer Patients: A Systematic Review and Meta-Analysis
Authors: Eun Hong-Bum , Baek Seung-Soo
Published: November 2021

PURPOSE: Cancer-related cognitive impairment (CRCI) is exposed to cognitive impairments that interfere with their daily lives after a complete recovery. Exercise is one of the effective non-pharmacological treatments to prevent or improve cognitive function decline. This study evaluated the effects of exercise interventions on cognitive function improvement in CRCI breast cancer patients and searched the association of various aspects in which exercise affects cognitive function improvement.METHODS: PubMed, ScienceDirect, ACS journal, and Google scholar databases from 1 January 2014 to 31 May 2021 were utilized for searching articles related to research purpose. Meta-analysis was conducted with Comprehensive Meta-Analysis 2.0 using the random-effect model.RESULTS: A meta-analysis of seven studies showed that walking (ES=0.59, p=.000) was the most effective in improving cognitive function, and moderate-intensity (ES=0.60, p=.000) was more effective than moderate-to-high intensity (ES=0.27, p=.007) exercise in CRCI patients with breast cancer. Cognitive function improvement was observed in short-term exercise intervention for four weeks (ES=0.46, p=.038), and after that, it was found that the cognition improvement effect was maintained or improved through long-term (12 or 24 weeks) exercise. Moreover, the cognitive function of CRCI patients with breast cancer improved without supervision during exercise interventions (ES=0.39, p=.001).CONCLUSIONS: Walking and moderate-intensity exercise can suppress cognitive impairment in CRCI patients with breast cancer. Personalized exercise prescription through short-term and long-term exercise periods can alleviate cognitive decline and improve the cognitive function of CRCI breast cancer patients. Exercise interventions without supervision also show a positive influence on cognitive function improvement.
Role of optical illusions and acoustic effects in the city architecture and the assessment of their impact on human
Authors: Khlebnikov Sergey , Kurochkina Valentina , Chernykh Valerii , Soloviev Kirill
Published: November 2021

The modern person spends the most part of time in the urban environment. Any environment influences human. At the moment, the issue of psychological impact of architecture on people is especially topical. The analysis of the foreign and domestic developments and research, describing the influence of urban development, architecture of buildings and the interior of rooms in terms of architecture psychology is presented in the article. The authors studied the phenomenon of architecture psychology during the research as well as the main methods of psychological influence, characteristic of architecture, and methods of their realization in practice.
The research concerns the optical illusions and acoustic effects in architecture objects, having the largest potential as instruments of psychological impact on human. The authors of the article developed classification of optical illusions by the purposes of their use and the nature of origin during the research. The most striking examples of the use of optical illusions and acoustic effects in already existing buildings and structures are reviewed in the article. The main design methods of the similar phenomena are also provided.
The negative impact of noise pollution is also considered in the work besides the positive impact of sound on human. Its sources and measures, directed to the decrease in negative noise impact, are also described.
The principles of the creation of positive sound influence in architecture were studied. The extent of impact of these architectural acceptances on psychological state of human is revealed as the result. According to that the conclusions are drawn on the need of taking into account of psychological influence of objects of architecture at the design stage.
PLANEJAMENTO ECONÔMICO E EDUCAÇÃO
Authors: Azevedo Campos Renata
Published: November 2021

O presente artigo traz um estudo da relação entre o Ministério do Planejamento e o Ministério da Educação, no contexto da ditadura empresarial-militar brasileira, que se inicia com o golpe de 1964. Com essa proposta, buscamos compreender as mediações do empresariamento da educação, no interior da sociedade política, a partir da análise das relações de poder entre suas agências, hierarquicamente distribuídas. Tomando o MEC como ponto de partida, defendemos que sua agenda foi subordinada ao planejamento econômico, no contexto em destaque, materializando a subsunção da educação às demandas de reprodução do capital. Para sustentar tal hipótese, trazemos uma análise dos planos do Ministério do Planejamento, observando o lugar destinado à educação, na sua relação com a Teoria do Capital Humano, então hegemônica. Com a mesma finalidade, levantamos os programas desenvolvidos pelo MEC, nas diferentes gestões ministeriais, de 1964 a 1975, perseguindo a relação entre as duas agências, tanto nos fundamentos das políticas, quanto na representação em sua organização.
Output Space Entropy Search Framework for Multi-Objective Bayesian Optimization
Authors: Belakaria Syrine , Deshwal Aryan , Doppa Janardhan Rao
Published: November 2021

We consider the problem of black-box multi-objective optimization (MOO) using expensive function evaluations (also referred to as experiments), where the goal is to approximate the true Pareto set of solutions by minimizing the total resource cost of experiments. For example, in hardware design optimization, we need to find the designs that trade-off performance, energy, and area overhead using expensive computational simulations. The key challenge is to select the sequence of experiments to uncover high-quality solutions using minimal resources. In this paper, we propose a general framework for solving MOO problems based on the principle of output space entropy (OSE) search: select the experiment that maximizes the information gained per unit resource cost about the true Pareto front. We appropriately instantiate the principle of OSE search to derive efficient algorithms for the following four MOO problem settings: 1) The most basic single-fidelity setting, where experiments are expensive and accurate; 2) Handling black-box constraints which cannot be evaluated without performing experiments; 3) The discrete multi-fidelity setting, where experiments can vary in the amount of resources consumed and their evaluation accuracy; and 4) The continuous-fidelity setting, where continuous function approximations result in a huge space of experiments. Experiments on diverse synthetic and real-world benchmarks show that our OSE search based algorithms improve over state-of-the-art methods in terms of both computational-efficiency and accuracy of MOO solutions.
High Leys service reservoir: a semi-precast construction
Authors: Aujla Navdeep , Edmondson Mark , Dixon Mike
Published: November 2021

High Leys Service Reservoir (SR) was required as part of the West Cumbria Water Supplies Project (WCWSP) by United Utilities PLC to feed the south-western region of the network including Egremont, Whitehaven and local regions. The principal contractor was Mott MacDonald Bentley. The site was chosen for its strategic elevated position to reduce outgoing pumping and provide adequate pressure within the WCWSP network. With a footprint of 10 512 m2 (109.5 m × 96 m) and 50 ML storage capacity, the SR comprises a semi-precast concrete (PCC) system (precast/in situ composite). As of March 2021, High Leys SR stands as the largest semi-precast SR in Europe. Due to the size and complexity of the scheme, elements of the design and construction were constrained by the requirements of the Lake District National Park Steering Group. Enabling works commenced in June 2018 followed by SR construction through 2019, with planned completion late 2021. This paper details the phases of construction highlighting key design philosophies and construction techniques. Furthermore, the benefits of implementing a PCC system instead of a traditional in situ construction for a potable water-retaining structure are discussed. The paper identifies benefits associated with design, quality assurance, speed of construction, sustainability, safety and innovations.
Piloting a Diversity, Equity, and Inclusion Needs Assessment to Explore Patron Perceptions at a University Health Science Library
Authors: Morgan-Daniel Jane , Adkins Lauren E. , Tennant Michele R. , Norton Hannah F. , Hough Chloe , Edwards Mary E. , Daley Matthew , Rethlefsen Melissa L.
Published: November 2021

Objective:
A pilot diversity, equity, and inclusion (DEI) needs assessment was conducted at a health sciences library. The objectives were to 1) quantitatively assess patrons’ attitudes towards the existing DEI climate in the library and 2) qualitatively identify contextual factors influencing patrons’ perceptions.
Population:
The assessment was led by a DEI Team at the University of Florida’s Health Science Center Libraries (HSCL). HSCL serves the university’s six health science colleges from two sites, Gainesville and Jacksonville. HSCL Gainesville was selected as the study location, due to higher annual footfall within the physical library.
Methods:
Two “HappyOrNot” customer satisfaction machines were placed by library exits. Twelve DEI-related questions were displayed on the machines, one question per week, for the duration of 12 weeks total. Additionally, a box for open-ended comments was placed by each machine.
Findings:
The total number of responses was 3,445, with 7 written comments. Overall, respondents felt happiest with the library’s welcoming and home-like environment. The library was perceived by many as a physically safe space. Most also felt that the library demonstrates a commitment to DEI and that they are treated fairly, equitably, and with respect by library staff. Areas of concern were a perceived lack of respect from other library visitors, as well as library services for patrons with disabilities and non-native English language speakers.
Conclusions:
The project enabled the HSCL to gather important information concerning patrons’ perceptions of the library’s DEI climate and their associated needs. The HappyOrNot machines provided a straightforward and convenient method for patron feedback, resulting in an impressive number of responses. However, limitations of the pilot included the inability to obtain participants’ demographic information, as well as the anecdotal evidence indicating that some respondents did not read the questions. Future plans therefore involve a follow-up online survey with detailed demographic questions.
The The Effect of Delta-9-Tetrahydrocannabinol and Cannabidiol on Blood Flow
Authors: James Tameika , Watson Charah , Pepple Dagogo
Published: November 2021

Background: This study is based on the premise that while consumption of cannabis has increased for medicinal and recreational purposes there has also been an increase in adverse events seemingly associated with cannabis usage. Objective: This study was designed to investigate the effect of different concentrations of Delta-9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD) separately and in combination on blood flow. Method: Forty male Sprague-Dawley rats were randomly divided into eight groups consisting of five rats each. Six of the test groups received different concentrations of THC and CBD (1 and 2 mg/kg body weight) respectively, while the seventh group received an extract with a combination of THC and CBD (2 mg/kg body weight) in a one to one ratio. The control group received the vehicle only. Drugs were administered intraperitoneally on alternate days for five days. Blood flow readings were taken at 0, 15, 30, 45 & 60 minute intervals using the CODA non-invasive blood pressure system. Results: The results indicate that blood flow decreased with increasing THC concentration and was significant (p < 0.05) at 45 minutes with 2 mg/kg dose. CBD caused an increase in blood flow with increasing concentrations and this was also significant (p < 0.05) at 45 minutes with 2 mg/kg dose. The extract however caused a non-significant decrease in blood flow. Conclusion: The results suggest that THC and CBD have opposing effects on blood flow separately, but when used in combination THC seems to exert a greater effect on blood flow than CBD.
Experience with Azilsartan and Azilsartan Combined with Chlorthalidone in a Preventive Cardiology Center. Fighting the Therapeutic Inertia with a Program Based on Evidence, Personalization, and Empowerment
Authors: Morales-Villegas Enrique , Alcocer-Diaz-Barreiro Luis , Moreno-Virgen Gualberto
Published: November 2021

In patients with hypertension (HT), cardiovascular risk reduction is directly proportional to the reduction in blood pressure sustained over time. However, in “real life,” blood pressure control is often insufficient or not sustained over time to achieve optimal cardiovascular risk reduction. In this article, we comment on the multiple reasons which explain this common therapeutic failure. Also, in this article, we summarize the amazing basic and clinical phase III evidence of azilsartan (AZL) and azilsartan combined with chlortalidone (CLD), two excellent therapeutic options for HT control. With such evidence as scientific background, we communicate our results with almost 300 HT patients treated with azilsartan and azilsartan/chlortalidone in "real life." In brief, our findings were the following: a) In HT patients with blood pressure (BP) <150/90 mmHg, AZL 40 mg as monotherapy provides practically 100% success to achieve a target BP <140/90 and <130/80 mmHg, in a subpopulation that we have called “hyper-responders” b) In HT patients with BP <150/90 mmHg (naive or with another treatment failure), AZL/CLD 40/12.5 mg provides practically 100% success to achieve a target BP <140/90 mmHg and 90% to achieve a target BP <130/80 mmHg; c) In HT patients with BP >150/90 mmHg (generally with another treatment failure), AZL/CLD 80/12.5 mg gives women a success rate greater than 60% to achieve a target BP <140/90 mmHg and greater than 50% to achieve a target BP <130/80 mmHg. The success rates were higher in men, greater than 75% to achieve a target BP <140/90 mmHg and greater than 60% to achieve a target BP <130/80 mmHg. In both cases, the use of amlodipine (2.5, 5, or 10 mg) made it possible to achieve a target BP <140/90 mmHg in 100% of the cases and <130/80 mmHg in 80% of the cases. Finally, according to our results, we propose a simple three-step strategy based on evidence, personalization, and empowerment which allows reaching a target BP <140/90 mmHg in more than 90% of cases and a target BP <130/80 mmHg in more than 75% of cases in 4 to 12 weeks.
The Effects of Conjugated Linoleic Acid and Berberine Supplementation on Markers of Allopurinol Activated Oxidative Stress in Broiler Chickens
Authors: Dartigue Vincent , Dyke Knox , Klandorf Hillar , Barnes Kimberly
Published: November 2021

Selection for rapid growth in poultry can be linked to an exaggerated state of oxidative stress (reactive oxidative species). Reactive oxidative species are kept in balance by endogenous and exogenous antioxidants. Two compounds, conjugated linoleic acid (CLA) and berberine a purified compound from plant root extract have been suggested to ameliorate oxidative stress. A six-week study examined the effect of CLA and berberine supplementation on markers of oxidative-stress in poultry. Day old broiler chickens (n=60) were equally divided into six groups; a control, a CLA group where half of the regular oil used in a standard was substituted for a CLA oil mixture, a berberine group consisting of berberine supplementation, an allopurinol group, a CLA and allopurinol with the same dose as the CLA and allopurinol groups and a berberine and allopurinol group. The allopurinol was added to induce an oxidative stress state. Body weight, plasma uric acid, plasma glucose, and relative gene expression of six endogenous liver antioxidants were measured during the course of the study. The addition of allopurinol to the diet induced an oxidative stress state as measured by a significant reduction in plasma uric acid. There were no significant changes in BW and blood glucose concentrations. There was a 10-fold increase in the relative mRNA expression of superoxide dismutase 2 and 3 as well as glutathione peroxidase 1 and 3 in CLA+ALLO and BRB+ALLO treatment groups. Notably, CLA increased the expression of uncoupling protein 19-fold compared to control, while the addition of allopurinol blocked these changes. In contrast, there was a slight increase in the uncoupling protein in the BRB+ALLO treatment. Despite the increase in mRNA expression of the antioxidants genes, these results suggest that at the dosages administered, CLA and berberine were not effective in reversing the oxidative stress induced by allopurinol.
Exposure to Actinobacteria resident in water-damaged buildings and resultant immune injury in Chronic Inflammatory Response Syndrome
Authors: Shoemaker Ryan , Meinhardt J , Heyman A , Lark D
Published: November 2021

The indoor air quality literature has expanded to include a wider variety of contaminants responsible for adverse human health effects. The increased use of Next Generation Sequencing (NGS), combined with the advent of transcriptomic assays, has defined specific causation of innate immune activation within this growing list of pathogenic microbes. Here we report the correlation of specific Actinobacteria as shown by NGS, with specific differential gene activation, using a transcriptomic assay (GENIE; Progene Dx, LLC, Bedford, Massachusetts). The study provides newly described indices of dominance (DI) and prevalence (PI) for exposure to Actinobacteria that have enabled clinicians to develop targeted treatment protocols to improve health issues as shown by reduction of symptoms, restoration of normal proteomics and transcriptomics, and correcting molecular hypometabolism (MHM), upregulation of MAPKs and TGFBR, as part of a chronic inflammatory response syndrome (CIRS), acquired following exposure to the interior environment of a water-damaged building (WDB). NGS has shown differences in populations of Actinobacteria found in WDB that are paralleled by differences in innate immune responses. Actinobacteria carried on human skin (HH, human habitat), as opposed to dwelling in soils (SH, soil habitat), consistent with prior publications, can now be represented by DI and PI pinpointing of specific areas of WDB requiring remediation. A review of the literature shows the capability of HH organisms to induce inflammatory processes in skin and systemically. In addition, the rapid expansion of research on extracellular vesicles suggests a reasonable basis for a mechanism by which resident HH initiate a cascade of inflammatory and metabolic events leading to adverse health effects following exposure to Gram-positive organisms, particularly lipophilic Corynebacteria, Cutibacteria and Mycobacteria, all of which contain mycolic acids in their cell walls. The role of unique structural differences in specific mycolic acids stratifying those Actinobacteria that are inflammatory may become fertile ground for the treatment of HH-associated illnesses, including CIRS. A review of the biology of receptors for TGF beta-1 adds to the importance of preventing the downstream signaling from upregulated TGFBR in illness associated with elevated PI. The aim of the paper is to identify distinguishing clinical features, including inflammation and immunoreactivity involving MAPK and TGFBR that are seen in illness associated with indoor exposure to Actinobacteria.
LACChain ID Framework: A Set of Recommendations for Blockchain-Based Interoperable, Privacy-Preserving, Regulatory Compliant, Secure, and Standardized Digital Identifiers, Credentials, and Wallets
Authors: Allende Marcos
Published: November 2021

This framework is a set of recommendations for the development of Self Sovereign Identity based solutions which can be applied in both public and private implementations. It covers decentralized identifiers, verifiable credentials and presentations, digital wallets, on-chain public key directories and trusted lists, on-chain roots of trust and frameworks, regulations, and trust frameworks.
Propuestas de marketing territorial para la promoción del centro de Medellín como destino turístico cultural entre jóvenes universitarios
Authors: Muñoz Arroyave Elkin Argiro , Isaza Arredondo Germán Andrés
Published: November 2021

En la actualidad, el marketing o mercadeo territorial es una estrategia que permite aprovechar las construccionessociales históricas en los territorios, con el fin de mejorar su desempeño económico. El turismo es una de las actividades que más utilizan esta estrategia, ya que es una forma de promoción adecuada para incentivar la visita de foráneos y residentes. En el caso de Medellín, el centro es el lugar en el que surgió la ciudad; sin embargo, esta zona sufre un deterioro físico y de seguridad, debido a la problemática delincuencial que allí se vive. En este orden de ideas, el objetivo de esta investigación es determinar estrategias de marketing territorial que aporten a la promoción del centro de Medellín como destino turístico cultural doméstico entre jóvenes de universidades públicas. Para ello, se utilizó el método inductivo conenfoques y técnicas cualitativas y cuantitativas de recolección de información para el análisis. Se concluye que el marketing territorial permite impulsar el turismo en territorios específicos e, igualmente, que los jóvenes universitarios podrían ver en el centro de la ciudad un nuevo espacio de ocio cultural, aunque es necesario el apoyo de la Alcaldía y de otras instituciones para financiar esta actividad.
Protokół zmieniający bilateralną umowę podatkową Polski z Holandią w świetle stanowiska Polski wobec Konwencji wielostronnej oraz aktualizacji Konwencji Modelowej OECD w sprawie podatku od dochodu i majątku z 2017 r.
Authors: Kukulski Ziemowit
Published: November 2021

Artykuł dotyczy zmian wprowadzonych do zawartej w 2002 r. bilateralnej umowy podatkowej Polski z Holandią mocą Protokołu zmieniającego tę umowę podpisanego 29 października 2020 r. Umowa ta nie została objęta postanowieniami Konwencji wielostronnej implementującej środki prawa traktatowego mające na celu zapobieganie erozji podstawy opodatkowania i przenoszeniu zysku. W związku z tym wprowadzenie do niej klauzul antyabuzywnych oraz rozwiązań usprawniających rozwiązywanie sporów musiało nastąpić w drodze dwustronnych negocjacji. Autor analizuje wpływ Konwencji wielostronnej, KM OECD oraz KM ONZ na kształt zaadaptowanych w nim rozwiązań oraz ich znaczenie dla przyszłości polskiej praktyki traktatowej.
Is soybean therapy better than ClinOleic for reducing recovery time in cats with permethrin toxicosis?
Authors: Gordon Shadira
Published: November 2021

PICO question

Is soybean oil-based intravenous lipid emulsion (IVLE) therapy more effective than olive oil-based (ClinOleic IVLE therapy) for reducing time to recovery in cats with permethrin toxicosis?

 

Clinical bottom line

Category of research question

Treatment

The number and type of study designs reviewed

Five case reports and one randomised clinical trial

Strength of evidence

Weak

Outcomes reported

Soybean oil-based and ClinOleic IVLE therapies can be used safely as adjuvant treatments to reduce time to recovery in cats with permethrin intoxication. However, the evidence collected suggests that soybean oil-based IVLE therapy is better in reducing the recovery time after permethrin toxicosis as compared to ClinOleic IVLE therapy

Conclusion

The overall findings showed that the average recovery time after soybean oil-based IVLE therapy across patients with permethrin intoxication was 8.5 hours and the average time to recovery after olive oil-based emulsions (ClinOleic therapy) was 39 hours. This may suggest that soybean oil-based formulations are a better option for reducing the recovery time in cats after permethrin toxicity. Dermal decontamination, supportive care, muscle relaxers, and anticonvulsant drugs are examples of recommended treatments before the administration of any intralipid therapies and must be used based on the clinical signs of each patient

 

How to apply this evidence in practice

The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.

Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
Prática da Amizade como Sublevação à Biopolítica Neoliberal
Authors: Vicentin Marcelo , Pereira David , Silveira Carlos Roberto
Published: November 2021

Este ensaio propõe-se a problematizar a prática da amizade por Michel Foucault como peça de resistência ao modo de vida neoliberal. Para tanto, o texto organiza-se a partir das discussões produzidas por Foucault sobre a amizade como um modo de vida e um exercício político de resistência a um poder governamental, e as discussões sobre o neoliberalismo em Nascimento da biopolítica. Por conseguinte, busca, com o auxílio de comentadores da obra de Foucault, primeiramente, apresentar o neoliberalismo e seu prazer-mor: a concorrência. Na sequência, apresentar a noção de amizade para Foucault dentro do quadro do cuidado de si e do epicurismo, para na continuação, discorrer sobre a amizade como uma prática política e, como tal, um exercício de resistência ao neoliberalismo, como uma prática ontológica sobre nós mesmos, contrapondo-se ao empresariamento de si e a concorrência, e nossas considerações finais, acentuando as invenções e arte de existência que a amizade oportuniza.
La vida en sentido extramoral. Ensayo sobre la inquietud de sí como política de la desindividualización
Authors: Vignale Silvana
Published: November 2021

El presente artículo aborda el trabajo de Michel Foucault sobre el bíos –parte de su estudio sobre la inquietud de sí en el ascetismo pagano– en el marco de luchas contra el gobierno de la individualización. Desde esta perspectiva se sostiene que una ética de sí, lejos de presentarse como salida individualista, responde a una historia marginal respecto de las relaciones entre sujeto y verdad. La historia del bíos quedó oscurecida por la historia del desarrollo del alma-sujeto, de una metafísica de la identidad y del individuo como efecto del gobierno de la individualización. A partir de ello se busca hacer converger dos genealogías. Por una parte, la de la ontología del yo y de la docilidaddel cuerpo –coincidente con el desarrollo de la inquietud de sí del modelo platónico de la reminiscencia y de la exégesis del yo del ascetismo cristiano–, con una genealogía de la moral que manifiesta la hostilidad del ideal ascético hacia la vida. En este sentido, el rescate de la historia del bíos se manifiesta no solo como política de la desindividualización, sino que reinstala, a la vez, para nuestro presente, la paradoja de la imposibilidad y la urgencia de una ética de sí contemporánea.
Stress Urinary Incontinence during Pregnancy in Primigravidae and Their Quality of Life
Authors: BORA ALKAN Gizem , DİNÇ Ayten
Published: November 2021

This research was performed to determine the risk factors causing stress urinary incontinence (SUI) and its effect on quality of life during pregnancy in primigravidae. The study is a cross-sectional study conducted with 324 primigravidae who were followed up in the antenatal outpatient clinics. Incontinence quality of life scale (I-QoL) questionnaire exploring the risk factors for SUI was used as the principle data collection tool. The prevalence of SUI during pregnancy was 38.6% (125/324). Multivariate analysis; maternal UI (OR = 2.9, 95% CI:1.5-5.5), sister having UI (OR = 5.6, 95% CI:1.5-20), gestational DM (OR = 3.3, 95% CI:1.2-8.6), pre-pregnancy BMI (OR = 1.08, 95% CI:1.0-1.1), smoking (OR = 4.3, 95% CI:1.8-10.2), constipation (often) (OR = 6.2, 95% CI:2.2-17) were determined as risk factors for SUI. It was determined that SUI during pregnancy affects the quality of life of women slightly. According to the results of this study, SUI is a common condition during pregnancy in primigravida. The findings will increase the awareness of healthcare professionals about SUI and contribute to the design of programs for the prevention of urinary incontinence during antenatal period.
FAKTOR-FAKTOR YANG MEMPENGARUHI CUSTOMER RETENTION: KASUS DARI LINKAJA [FACTORS AFFECTING CUSTOMER RETENTION: CASE OF LINKAJA]
Authors: Yang Hezekiah Andersen , Wuisan Dewi S. S.
Published: November 2021

This study uses trust, reliability, responsiveness, website design, convenience, and personalisation as independent variables to determine the impact on customer retention on LinkAja users and help discover the problem that shifted LinkAja's position from the second largest in Indonesia, to the fourth. LinkAja is one of the online payment applications in Indonesia similar to that of Gopay, DANA, OVO, etc. This study also seeks to provide recommendations on how LinkAja can improve its position and be more competitive. This study uses questionnaire for data collection. Data analysis used is structural equation modeling (SEM) with SmartPLS and using reliability, validity, and multicollinearity analysis. The actual data collected used comprise of 140 women and 140 men. The results showed, in the case of female users, trust, reliability, and responsiveness were had no effect on customer retention. While for men, trust and website design have no effect on customer retention.

BAHASA INDONESIA ABSTRACT:

Penelitian ini menggunakan Trust, Reliability, Responsiveness, Website Design, Convenience, dan Personalisation sebagai variabel independen untuk mengetahui dampak terhadap Customer Retention pada pengguna LinkAja dan membantu masalah tergesernya posisi LinkAja yang tadinya pada urutan kedua terbesar di Indonesia, menjadi urutan ke 4 di mana LinkAja merupakan salah satu aplikasi pembayaran online di Indonesia seperti Gopay, DANA, OVO, dan lainnya. Memberikan rekomendasi mengenai bagaimana cara LinkAja dapat menaikkan posisinya dan dapat lebih kompetitif dengan perusahaan-perusahaan pesaing. Pada penelitian ini menggunakan kuesioner untuk data. Analisis data digunakan dengan menggunakan structural equation modelling (SEM) melalui SmartPLS dan menggunakan reliability, validity, dan multicollinearity analisis. Data aktual dibagikan kuesioner sebanyak 140 kepada wanita dan 140 kepada laki-laki. Hasil penelitian menunjukan, pada responden wanita, variabel trust, reliability, dan responsiveness adalah variabel yang tidak berpengaruh terhadap customer retention. Sedangkan pada laki-laki, trust dan website design merupakan variabel yang tidak berpengaruh terhadap customer retention.
Young College Students’ Perception of DINESERV: A Study of On-Campus Dining in the USA
Authors: Choi Hyunsuk , Kong Erick , Ann Saehya
Published: November 2021

Purpose – The purpose of this research is to better understand why college students in the USA eat on-campus. Also, this research aims to compare highly satisfied and low satisfied groups in terms of their on-campus dining experiences and behaviors and to understand what values college students are currently satisfied with and what they expect from their on-campus dining. Design – A survey design was implemented in this study. The sample for this research study is any college students who have eaten at on-campus dining facilities within the last 3 months. Methodology – Cluster analysis, correlation, and t-test were utilized for data analysis. The twostep clusters method was used to cluster groups based on the mean values of DINESERV. Approach – The validity of DINESERV for on-campus dining settings was examined, as well as examining the behavior and perception of Generation Y and Z on on-campus dining. Findings – In both clusters, Assurance was the factor with the highest correlation coefficient value, while Tangible ranked last among the five DINESERV factors. The other dimensions of DINESERV were also very important to the young college students, as indicated by the high correlation coefficients. Originality of the research – This research examines the validity of DINESERV in on-campus dining settings in the United States. The uniqueness of this study lies in the sample: young college students, Generation Y and Z.
Eyebrow tufts, display and other behaviour in nesting Metallic Starlings Aplonis metallica
Authors: Frith Clifford
Published: November 2021

Observations made at an active nesting colony of Metallic Starlings Aplonis metallica, during the nest-building phase of the breeding cycle, resulted in the description and photographic illustration of a vigorous wing-flapping greeting or pair-bonding display performed on or beside nests under construction. Erectile eyebrow tufts of elongate sharply pointed feathers above each eye are described and illustrated, apparently for the first time in this species.
Conceptualizing Humane Buying and Its Role in Reducing Rural Farmers’ Vulnerability in a Post-Pandemic Era
Authors: Agu Agu Godswill , Okpara Gazie Sunday , Ogwo Ogwo Ekeoma , Ogbuji Chinedu Nnaemeka , Anyanwu Aham Vitalis
Published: November 2021

While several studies have examined the impact of the Covid-19 pandemic on smallholder rural farmers and possible efforts to scale up their livelihood and food security, the role of consumers’ buying orientation in addressing farmers’ vulnerability in the post-pandemic era has not been explored. The paper, therefore, aims to propose and conceptualize humane buying orientation, and further explore its role in attenuating smallholder rural farmers’ vulnerability in the new normal. The qualitative design approach has been employed in two different studies. Collected data were analyzed using the SPSS 23.0 and following the interpretative phenomenological analysis. Findings validate humane buying as an altruistic orientation that will contribute to lessening the vulnerability of smallholder rural farmers in the post-pandemic era. It also shows that an enlarged-stakeholders’ (government, international agencies, corporate bodies, institutions, privileged individuals/consumers, religious organizations, etc.) effort that is rooted in morality and empathy, is required to successfully tackle the vulnerability of smallholder rural farmers, especially in developing countries such as Nigeria. The study is the first to propose, conceptualize and validate humane buying as a post-Covid-19 orientation that is capable of attenuating the vulnerability of smallholder rural farmers which has been worsened by the pandemic. The paper contributes to the understanding of emerging strategic actions required for the attainment of the United Nation’s sustainable development goals - ending poverty and hunger by 2030, and how consumers can play a key role.
Fabrication of Release Agent Supply Die with Porous Structure Using Metal-Based Additive Manufacturing
Authors: Chiba Hironao , Furumoto Tatsuaki , Hori Yuki , Nikawa Makoto , Hayashi Nobuhisa , Yamaguchi Mitsugu ,   Division of Mechanical Science and Engineering, Graduate School of Natural Science and Technology, Kanazawa University  Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan,   Advanced Manufacturing Technology Institute, Kanazawa University, Kanazawa, Japan,   Sippo Moulds Co., Ltd., Tsushima, Japan,   Department of Mechanical Engineering, Gifu University, Gifu, Japan
Published: November 2021

In powder bed fusion (PBF), a type of metal-based additive manufacturing (AM) process, metal powders are deposited on a substrate and melted through selective laser-beam irradiation. Among AM processes, PBF yields excellent dimensional accuracy, and the built parts can be applied to molding dies and topology-optimized parts. Furthermore, PBF can be used to build porous structures. In this study, a highly functional die casting method was established using PBF, which involved a release agent supplied through the porous structure to the surface of the proposed die. The arrangement of the porous structure made it possible to apply the release agent to the deep groove, which is not possible using a spray as in conventional supply methods. The laser-irradiated area was visualized to confirm pore formation, and the building conditions of the porous structure suitable to supply the release agent were investigated. The resulting die casting characteristics were evaluated. Considering the obtained results, guidelines to build dies or molds for die casting with porous structures are recommended. The amount of release agent could be controlled at each position of the die casting die, and the melted Al alloy did not penetrate the porous structure. In addition, the obtained Al alloy casting did not exhibit any castability defects. Moreover, suitable control of the supply of the release agent enabled enhancement of the die casting characteristics.
Total Hip Revision with a Custom Acetabular Component and Femoral Allograft-Prosthetic Composite as Salvage for Failed Unstable Megaprosthesis in an Adolescent Patient
Authors: Phocas Alexandra , Holst David C. , Angerame Marc R. , Kurkis Gregory , Dennis Douglas A.
Published: November 2021

Case:

A 13-year-old girl presented after a right proximal femur replacement after proximal femoral resection for treatment of an Ewing sarcoma. She presented after multiple episodes of recurrent instability with her hip endoprosthesis chronically dislocated. Her hip was revised to a custom, constrained metal-on-metal acetabular component with a small iliac flange. The femoral component was revised to an allograft-prosthetic composite. She has been free of malignancy recurrence, implant failure, or dislocation at 19-year follow-up duration.

Conclusion:

Dislocation of the prosthetic hip can be a challenging postoperative complication, particularly when associated with a tumor megaprosthesis in a pediatric age group. This is further compounded in the presence of deficient pelvic bone stock. Restoration of bone stock is optimal, but when impossible, custom components may be necessary to establish hip stability.
Fact checkers fail to overcome partisan divides in two of the world’s largest democracies
Authors: Ray Rik , Bhalla Sakshi , Taneja Harsh
Published: November 2021

Misinformation easily spreads on social media and fact-checkers have an important role in correcting falsehoods. Most misinformation is of a partisan nature and appeals selectively to users on the basis of ideology. Thus, it is possible that fact checks may not overcome existing ideological divisions on social media. We examine this separately for a slice of Twitter users, following certain partisan outlets from India and the US. In both cases, users of left-leaning news outlets are more likely to follow and share content by fact checkers. Followers of right-leaning outlets rarely follow or amplify fact checkers and only selectively engage to reply to posts by fact checkers. Our analysis of 7mn partisan news users from two of the world’s largest democracies suggests that exposure to fact-checking therefore remains largely restricted to left-leaning Twitter users with little evidence that these interventions penetrate among right-leaning slices, where partisan misinformation also circulates
High-performance hysteresis-free perovskite transistors through anion engineering
Authors: Zhu Huihui , Liu Ao , Shim Kyu In , Jung Haksoon , Zou Taoyu , Reo Youjin , Kim Hyunjun , Han Jeong Woo , Chen Yimu , Chu Hye Yong , Lim Jun-Hyung , Kim Hyung-Jun , Bai Sai , Noh Yong-Young
Published: November 2021

Despite the impressive development of metal halide perovskites in diverse optoelectronics, progress on high-performance transistors employing state-of-the-art perovskite channels has been limited owing to ion migration and large organic spacer isolation. Herein, we report high-performance and hysteresis-free p-channel perovskite thin-film transistors (TFTs) based on methylammonium tin iodide (MASnI3) and rationalise the effects of halide (I/Br/Cl) anion engineering on crystallinity enhancement and vacancy suppression, realising a high hole mobility of 20 cm2 V−1 s−1, current on/off ratio exceeding 107, and threshold voltage of 0 V with high operational stability and reproducibility. We reveal ion migration has a negligible contribution to the hysteresis of Sn-based perovskite TFTs; instead, minority carrier trapping is the primary cause. Finally, we integrate the perovskite TFTs with commercialised n-channel indium gallium zinc oxide TFTs on a single chip to construct high-gain complementary inverters, facilitating the development of halide perovskite semiconductors for printable electronics and circuits.
Large-scale Domain Engineering in Two-Dimensional Ferroelectric CuInP2S6 via Giant Flexoelectric Effect
Authors: Chen Chen , Liu Heng , Lai Qinglin , Mao Xiaoyu , Fu Jun , Fu Zhaoming , Zeng Hualing
Published: November 2021

Room-temperature ferroelectricity in two-dimensional materials offer a potential route for developing atomic-scale functional devices beyond Moore’s law. However, as a key for the technology implementations of ferroelectrics in electronics, the controllable generation of uniform domains remains challenging in two-dimensional ferroelectrics at current stage because domain engineering through an external electric field at 2D limit inevitably leads to large leakage current and material break-down. Here, we demonstrate a voltage-free method, the flexoelectric effect, to artificially generate large-scale stripe domains in two-dimensional ferroelectric CuInP2S6 with single domain lateral size at the scale of several hundred microns. With giant strain gradients (~106 m−1) at nanoscale, we mechanically switch the out-of-plane polarization in ultrathin CuInP2S6. The flexoelectric control of ferroelectric polarization is understood with a distorted Landau-Ginzburg-Devonshire double well model as evidenced by the shifted ferroelectric hysteresis loops and the first-principle calculations. Through substrate mechanical strain engineering, the stripe domain density is controllable. Our results not only highlight the potential of developing van der Waals ferroelectrics-based memories but also offer the opportunity to study ferroelectric domain physics in two-dimensional materials.
Bracovirus sneaks into apoptotic bodies transmitting immunosuppressive signaling driven by integration-mediated eIF5A hypusination
Authors: Luo Kaijun
Published: November 2021

The typical characteristic of polydnavirus (PDV) infection is persistent immunosuppression, governed by the viral integration and expression of virulence genes. Recently, how Microplitis bicoloratus bracovirus (MbBV) activates caspase-3 to cleave Innexins, gap junction proteins, has been highlighted, further promoting apoptotic cell disassembly and apoptotic body (AB) formation. However, little is known about how inserted viral fragments interact with host cells to drive apoptosis and the role MbBV-mediated extracellular vesicles play in immune suppression. Herein, we show that ABs transmitted immunosuppressive signaling, causing recipient cell apoptosis and dismigration. Overall, viral host integrated motif sites insertion damaged host genome stimulating eIF5A nucleocytoplasmic transport, activating the eIF5A-hypusination translation pathway. Functionally, translated apoptosis-related host proteins, such as P53, CypD, CypJ, and CypA, drive a broken dsDNA cellular apoptosis. Furthermore, translated viral proteins, vank86, 92, and 101, known to complex with transcription factor Dip3, positively regulated DHYS and DOHH transcription maintaining the activation of the eIF5A-hypusination translation pathway. Mechanistically, MbBV-mediated extracellular vesicles contained inserted viral fragments that re-integrated into recipients, potentially via the homologous recombinant repair system. Meanwhile, this stimulation regulated activated caspase-3 level via pI3K/Akt 308 and 473 dephosphorylation to promote recipients cell apoptosis; pI3K/Akt 473 phosphorylation inhibited caspase-3 activation leading to recipient cell dismigration. In conclusion, our results suggest that integration-mediated eIF5A hypusination drives extracellular vesicles for continues immunosuppressive.