bluuebunny/crossref_metadata_2025 huggingface dataset:
El cuerpo del atleta en la antigua Grecia: entre el ideal físico y el exceso
Authors: García Soler María José
Published: January 2025

En el mundo griego la figura del atleta se presenta con frecuencia como modelo del ideal humano. La escultura clásica muestra cuerpos que rozan la perfección y abundan las referencias al reconocimiento social que recibían sus actividades. Sin embargo, paralelamente surgen voces críticas contra sus excesos, en particular por parte de poetas e intelectuales, tanto en su preparación física, que, llevada al extremo, es causa de graves problemas físicos e incluso mentales, como por la admiración desproporcionada que reciben por sus actividades. En este artículo se pasará revista a los testimonios que reflejan esta doble faceta del mundo deportivo en la antigua Grecia.
Juan Luis Vives y la retórica clásica
Authors: Havu Kaarlo
Published: January 2025

Este artículo se enfoca en la recepción de la retórica clásica en la obra de Juan Luis Vives. Proponemos que Vives interpretó la retórica clásica como una creación del contexto político de la democracia y de la república en la Antigüedad clásica y aspiró a acomodar esa tradición a la realidad del siglo xvi. Al hacer esto, Vives resaltó la importancia del decorum, que ofrecía una solución al antagonismo verbal del momento y hacía posible una retórica convincente enun contexto nuevo.
Epitafio para el Maestro Arturo Ramírez Trejo. Bautizado Arturo Edmundo Guadalupe (1931-2024)
Authors: Reyes Coria Bulmaro
Published: January 2025

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O direito migratório na perspectiva comparada entre Brasil e Espanha: entre as políticas migratórias de proteção dos direitos humanos aos migrantes e refugiados e a criminalização das migrações contemporâneas
Authors: Tourinho Luciano de Oliveira Souza , Sotero Ana Paula da Silva
Published: January 2025

A proteção dos direitos humanos aos migrantes e refugiados tem sido um dos principais desafios do século XXI, uma vez que, apesar da legislação migratória internacional, que determina a cooperação entre as nações para acolhimento humanitário de todos os povos, há, na realidade, uma resistência para recepção dos sujeitos que estão em deslocamento forçado. Nesse desiderato, o estudo tem por objetivo analisar, numa perspectiva comparada, a interrelação entre as políticas criminais e as políticas migratórias adotadas na Espanha e no Brasil, no intuito de evidenciar que as práticas discriminatórias contra os povos migrantes e refugiados são alicerçadas no tratamento criminal às migrações irregulares, no processo de crimigração dos deslocamentos forçados. O problema da pesquisa centra-se em verificar a aproximação das políticas migratórias e as políticas criminais na realidade contemporânea do Brasil e da Espanha. O estudo é qualitativo. Os métodos foram o dedutivo e comparativo, com procedimentos metodológicos de análises bibliográfica e documental, para comparação da Espanha e do Brasil, abalizada pela análise das políticas criminais e as políticas migratórias que dão ensejo ao processo de criminalização das migrações. A hipótese da pesquisa é de que se operou o endurecimento das políticas migratórias com a crimigração fática na Espanha, com a adoção do art. 318 bis no Código Penal Espanhol. Já no Brasil, a crimigração é simbólica, categorizando os migrantes como inimigos. A partir dos estudos, foi possível observar que as práticas discriminatórias são revestidas de discursos de desqualificação e criminalização da figura dos migrantes e refugiados.
Female single-parent family: a public policy issue
Authors: Giordano Marina Couto , Carvalho Alexandre Ventin de , Belisário Katia Maria
Published: January 2025

The traditional family unit consisting of a father, mother, and children no longer prevails in society as it did decades ago, giving way to other family structures such as the single-parent family, where only one person takes on the parenting role. This article aims to analyze the conditions for implementing public policies aimed at preventing or mitigating the impact of gender inequality in single-parent families led by women. The question guiding the research is what public policies can be effective in mitigating discrimination and unequal treatment given to female single-parent families. The starting point was a theoretical review of Brazilian single-parent families, the causes and impacts of gender inequalities, and public policies. The methodological process includes the SWOT matrix analysis (an acronym in English for the words strengths, weaknesses, opportunities, threats) for diagnosing barriers to the implementation of suggested public policies. The hypothesis is that some social barriers make it difficult to implement public policies for single-parent families. The results show social barriers such as: lower income attainment; limited access to basic goods and services for members of single-parent families due to their low income; uncertain insertion into the job market; no proper family assistance; intensification of women’s double workload; school dropout; physical and psychological illness. Public policies are suggested based on the study.
O déficit financeiro no sistema previdencial
Authors: Costa Eliane Romeiro
Published: January 2025

O déficit securitário e a insatisfação da sociedade solidária tendem a alterar os níveis de segurança humana no sistema social contemporâneo. A insuficiência financeira na solidariedade coletiva que confronta o dever público de cuidado como mito construído no século XX é objeto desta análise, a qual adota o valor da universalidade de cobertura e a sobrevivência como essenciais para a renda e a manutenção dos benefícios dignos e básicos. O tratamento da cultura do déficit sugere proposições que buscam não apenas reformar, reduzir e/ou transformar a técnica do cuidado, mas descredibilizar e desconectar a malha solidária, arriscando reintroduzir a desproteção social mais ampla. Portanto, na presente seara, o paradoxo da linguagem de direitos – operando tanto na distribuição de renda e de direitos securitários e sociais quanto na grafia da justiça social universal e básica pretendida com a proteção internacional dos direitos humanos – é confrontado com a era da incerteza provocada pela cultura deficitária que reage influenciando a remissão da solidariedade contributiva e minimizando os direitos do cuidado, bem como a expectativa de segurança humana para as presentes e futuras gerações de contribuintes e de assistidos. Nesta abordagem, são recepcionados os preceitos principiológicos de dignidade existencial; a teoria da necessidade, da cooperação e do cuidado para a viabilidade da segurança social e humana; as doutrinas ocidentais de direitos humanos e sociais; além das análises econômicas e fiscais acerca da demografia, da cobertura, do déficit atuarial e financeiro securitário e dos riscos previdenciários. O déficit financeiro no sistema previdencial repercute em crises fiscais reformadoras de direitos sociais fundamentais tendentes a inviabilizar o sistema de confiança social em curto prazo. A sociedade atrelada à cultura do déficit sistêmico assiste inoperante à decadência dos direitos dos beneficiários do seguro social. Assim, o presente estudo se propõe a analisar as incertezas provocadas pelo ambiente de reforma permanente sob a justificativa de déficit fiscal estrutural.
Obrigação tributária digital
Authors: Nagib Luiza , Alecrim Eliza Remédio
Published: January 2025

A informatização da administração pública e a mudança no meio de cumprimento das obrigações tributárias acessórias, que passaram a ser digitais, não pode acarretar na violação à norma geral e abstrata, ou aos princípios tributários previstos na Constituição Federal. As obrigações tributárias acessórias devem ser previstas em lei e ter como finalidade instrumentalizar a fiscalização e arrecadação de tributos. O objetivo deste artigo é o de apontar para o panorama e possíveis tendências na imposição das obrigações acessórias digitais no Brasil, para com isto identificar se os limites impostos são respeitados na instituição destas imposições. A metodologia utilizada consistiu em estudo qualitativo, com aplicação do método empírico-dialético, por meio pesquisa bibliográfica e documental, na análise do direito positivo. Foram analisadas as regras de criação do Sistema Público de Escrituração Digital (SPED), do Estatuto Nacional de Simplificação de Obrigações Tributárias Acessórias, do Programa de Conformidade Tributária e do Projeto de Eliminação da Guia de Apuração (GIA) do Imposto sobre Operações Relativas à Circulação de Mercadorias e sobre Prestações de Serviços de Transporte Interestadual e Intermunicipal e de Comunicação (ICMS) paulista. Em que pese a intenção formalizada destes mecanismos ser justamente a de diminuir o custo das obrigações acessórias no Brasil, o que se percebe com a pesquisa é que, na prática, apesar da vanguarda das iniciativas, muito ainda há a ser feito, haja vista a constatação de que as obrigações acessórias digitais em nada simplificam, ou diminuem as incumbências tributárias, muito pelo contrário.
Embriões humanos excedentários ou "criados" a partir de células-tronco em Portugal e no Brasil: a relevância social de legislar
Authors: Barbas Stela Marcos de Almeida Neves , Santos Neto Manoel Pereira dos , Mota Shirlei Castro Menezes
Published: January 2025

A evolução das técnicas de Procriação humana tem levantado uma série de questões a serem pensadas e definidas por normas atentas aos princípios da Bioética. Em Portugal e no Brasil, o tratamento dado aos embriões excedentes, seja no tocante ao descarte ou uso para fins científicos, têm direcionamentos distintos. Entretanto, no Brasil, à exceção da Lei de Biossegurança de 2005 e das resoluções do Conselho Federal de Medicina desde 1992, ainda não há norma para contemplar casos mais complexos, embora exista projeto legislativo de alteração do Código Civil que poderá suprir essa lacuna, mesmo que em parte. Em Portugal, a Lei 32/2006 tenta se ajustar às constantes mudanças verificadas em torno da Procriação Medicamente Assistida, inclusive alargando os beneficiários desde 2016. Este artigo, realizado a partir de revisão bibliográfica e documental, busca mostrar preocupação ética no tratamento do material genético, face às normas que aí estão ou as que advirão, sobre o assunto, em especial no que diz respeito aos direitos da personalidade e ao princípio da dignidade humana. Além disso, trar-se-á do relato de 2023, em que cientistas anunciaram embriões “criados” a partir de células-tronco, ou “embriões sintéticos”. Essa realidade pode remeter a um futuro no qual pessoas geradas por PMA podem estar totalmente desvinculadas de sua verdade biológica; fato este cada vez mais plausível, numa era delineada pela escalada tecnológica, do aumento do uso da Inteligência Artificial e, reflexamente, do desenvolvimento do Direito Digital que a isso vem atrelado.
Level of Primary Disability of Children with Consequences of Infantile Cerebral Palsy
Authors: Gazdieva Bella M. , Puzin Sergey N. , Vladimirova Oksana N. , Milovanova Olga A.
Published: January 2025

Reforming the rehabilitation system for children with cerebral palsy is currently a pressing problem in the social sphere of the Russian Federation. The aim of the work is to analyze the state of disability in children with the consequences of cerebral palsy. The study used data from the Federal State Statistics Service, the Federal Register of Disabled Persons, and information from the Unified Automated Information System of the Medical and Social Expertise (EAVIISM). Analysis of data on the level of primary childhood disability in the Russian Federation due to diseases of the nervous system showed fluctuations in 2018–2021. Comparing the rates of primary disability in children with cerebral palsy in Moscow and the Central Federal District, there was a decrease in the number of children in this category from 332 to 228 people in Moscow and from 1160 to 790 people in the Central Federal District. Violations were often noted in children aged 0 to 3 years. According to the gender structure, boys prevailed mainly, their proportion was 57–58 %. In terms of the degree of disability in children, 1st and 2nd degree prevailed, the disorders were associated with self-care and movement. In general, the level of disability of children with cerebral palsy recognized for the first time in the Russian Federation is higher than in Moscow and the Central Federal District, this was explained by the presence in the Central Federal District and Moscow of a high level of medical and rehabilitation care for children with cerebral palsy.
Lean Competencies of Healthcare Professionals as a Basis for Improving the Efficiency of a Medical Organization
Authors: Mazunina Svetlana D. , Adzhienko Vsevolod L. , Isakova Lyudmila V. , Shulyatyeva Natalia V. , Karpova Ekaterina M.
Published: January 2025

Goal. The study of approaches to improve the efficiency of building lean competencies among healthcare professionals through quality management components (Donabedian triad) with an assessment of the result of invested educational investments. Materials and methods. The article presents the author's methodology for deploying advanced training programs in lean technologies through quality management of the Donabedian triad. The formation of training programs through the blocks "structure", "process", "result" is aimed at increasing the effectiveness of improving the necessary skills in the field of process improvement. As an example, the structure of one of the professional development programs is given with an assessment of the investments made in the skills of employees and on the results of the activities of a medical organization. Results. During the period of comparative analysis of training and implementation of the inventory management system in a medical organization, using the skills acquired during training, an assessment of the profitability of the invested costs for the resulting effect for a medical organization (ROI indicator) is shown. Each ruble invested in investments under the same conditions brought 46 rubles to the hospital. Scientific contribution. The formation of a methodology for practice-oriented postgraduate training programs with an assessment of their effectiveness in the long term on the activities of the organization, which requires continued research in this direction. Conclusion. The effectiveness of postgraduate training of specialists can be achieved only through joint consolidated approaches aimed at obtaining and improving the necessary skills that increase the effectiveness of the organization. The scope of application. The described concept of practice-oriented learning can be applied in any field of activity. Limitations of future research. Not revealed.
Influence of Dust Load Intensity on Immune Factors in Coal Mine Workers with Chronic Obstructive Pulmonary Disease
Authors: Lastkov Dmitry O. , Nikolenko Olga Yu. , Maylyan Eduard A. , Grishchenko Sergey V. , Prilutsky Alexander S. , Trunova Olga A. , Bagriy Andrey E. , Tishchenko Anna V.
Published: January 2025

Material and methods. Markers of mature T-lymphocytes (CD3), T-helpers (CD4), T-cytotoxic cells (CD8), normal killer cells (CD16) and B-lymphocytes (CD22) in peripheral blood were detected using monoclonal antibodies in the direct immunofluorescence assay. The concentrations of interleukins -1, -4, -6, -8 and -10 were determined in the blood serum of miners by the enzyme immunoassay method using the respective test systems. Results. It was found that COPD in miners is combined with cellular immunity disorders (decrease in the percentage of CD3+ and CD4+ lymphocytes, increase in CD22+ cells), and an increase in serum concentrations of IL-1β, IL-4, IL-6, IL-8, IL-10 (p 0.05). Conclusion. It is shown that immune disorders depend on the degree of dust pollution in the workplace, very high levels of dust load cause a more pronounced decrease in the percentage of CD3+ cells and an increase in serum levels of IL-4 and IL-8 (p 0.05). All of the above-mentioned changes are important to consider for the correct development of future measures for primary and secondary prevention of COPD in coal miners, as well as taking into account the dust levels of workplaces.
Features of Determining the Trusive Types of Dental Arches of Physiological Occlusion and Their Main Characteristics
Authors: Dmitrienko Tatyana D. , Yagupova Violeta T. , Yukhnov Ilya N. , Kerobyan Victoria I.
Published: January 2025

Determining the types of dental arches is a relevant topic of scientific and practical research. Purpose. Development of research methods and determination of the features of trusal types of dental arches of physiological occlusion. Material and methods. A retrospective cahort study of 62 pairs of plaster models of jaws, the occlusal status of which corresponds to the physiological norm, was carried out. To distribute the material according to the types of trusal arches, the recommendations of specialists were used with the measurement of the distal transversal and odontometry of 14 teeth of the upper and lower jaw. In the photographs of the models, central and distal points were established, which were connected by diagonal lines that formed a diagnostic triangle. When determining the angular parameters, the sine of the angles was mathematically calculated and measured using a protractor. Outcomes. The value of the index for the mesotrusive type was (0.68 ± 0.04) units, the value of the index less than 0.63 units is characteristic of the dental arches of the retrusive type, and more than 0.72 units is characteristic of incisor protrusion. The value of the incisal angle, for the mesotrusive type, ranged from 70 to 78°. An increase in the central angle of more than 79° determined the belonging of the dental arch to the retrusive types, and a value of less than 69° is characteristic of the protrusive arches. Conclusion. Thus, the resulting determination of the size of the trusal type and the incisal angle of the dental triangles of both jaws can be used to assess the features of the dental arches and their distribution according to the trusive type.
Fiches de reconnaissance pratique des arbres sur pied de la forêt guyanaise : Yayamadou montagne
Authors: Thiel Jean
Published: January 2025

Pas de résumé
Recherche expérimentale d'une méthode d'essai de la résistance des panneaux à la pourriture
Authors: Trong Lucien
Published: January 2025

Une méthode directement inspirée de la méthode normalisée française d'essai des panneaux contre la pourriture fongique est décrite (AFNOR N° 51.295 - mai 1980). L'infestation, localisée et contrôlée, est réalisée en conditions non stériles selon les principes de base utilisés ces dernières années à l'Unité de Préservation du Centre Technique Forestier Tropical, France. Les résultats obtenus après 12 semaines d'exposition aux basidiomycètes et le test de flexion statique ont permis d'évaluer l'efficacité de cette méthode d’essai direct.
Les filières d'approvisionnement en combustibles forestiers des villes de la zone sahélo-soudanienne
Authors: Bertrand Alain
Published: January 2025

Dans les pays de la zone sahélo-soudanienne, la croissance démographique influe sur les problèmes d'utilisation de l'espace, entraînant de profondes conséquences pour les forêts. La crise du bois reflète un déséquilibre entre la demande et le potentiel naturel. Elle concerne principalement les combustibles d'origine forestière, et est avant tout une crise urbaine qui a un impact rural. L'analyse des filières d'approvisionnement des grands centres urbains est donc une étape préalable à la recherche de solutions.Il s'agit d'un commerce traditionnel basé sur l'existence d'une typologie très spécifique de produits et lié à l'existence de microfilières étroitement adaptées à des conditions locales particulières.Le rôle fondamental de l'organisation des transports est souligné ; de sa structure dépendent les caractéristiques spécifiques qui différencient les filières d'approvisionnement des différents pays de cette zone.Les structures de prix reflètent les situations locales et leur évolution. La croissance des revenus des bûcherons, en particulier des agriculteurs, correspond à une revalorisation progressive des ressources forestières parallèlement à leur raréfaction.
Principes de l'électrophorèse et utilisation en génétique forestière
Authors: Vigneron Philippe
Published: January 2025

N.D.L.R. Nous publions dans les pages qui suivent un article sur le polymorphisme et la variété génétique de certaines provenances de Terminalia superba. Cette étude a été faite en utilisant la technique de l'électrophorèse. Nous avons donc pensé qu'il serait utile de rappeler à nos lecteurs les principes généraux de l'électrophorèse et de ses applications possibles en génétique forestière. C'est ce qui est fait ci-dessous.
Une autre opinion sur la "disparition" des forêts tropicales : extrait de "Botanistes, zoologistes et défense des écosystèmes des forêts tropicales humides"
Authors: Roche L. , Huguet Louis
Published: January 2025

Pas de résumé
Analisis Perbandingan Pelindungan Data Pribadi antara Indonesia dan Arab Saudi
Authors: Veranda Chessyca , Nusantara Muhammad Alwan Zain
Published: January 2025

Perkembangan teknologi dan informasi yang terus berlanjut akan berdampak signifikan pada kehidupan sehari-hari masyarakat, memungkinkan setiap orang untuk mengakses dan menggunakan berbagai informasi dengan mudah. ​​Namun, penggunaan teknologi sering kali diawali dengan data-data, yang digunakan untuk mengidentifikasi dan mengkategorikan individu berdasarkan penggunaan internetnya. Data-data ini harus digunakan secara bertanggung jawab, karena penyalahgunaan dapat menimbulkan masalah hukum dan potensi konsekuensi hukum. Penelitian ini menggunakan metode normatif. Data primer diperoleh dari Undang-Undang Nomor 27 tahun 2022 tentang Perlindungan Data Pribadi (UU PDP) dan Personal Data Protection Law (PDPL) Tahun 2023. Data sekunder meliputi jurnal, buku, artikel Ilmiah, dan karya ilmiah lain yang relevan. Hasil penelitian menunjukkan bahwa Indonesia dan Arab Saudi telah menerapkan regulasi perlindungan data pribadi melalui Undang-Undang Nomor 27 Tahun 2022 dan Personal Data Protection Law yang membahas privasi sebagai hak asasi manusia yang fundamental. Regulasi ini memiliki kesamaan prinsip, jenis, subjek, hak, dan kewajiban pengendali dan pengelola data pribadi. Namun, keduanya berbeda dalam hal lembaga pelaksana dan sanksi atas tindak pidana data. Persamaan dan perbedaan ini dapat menjadi panduan bagi Indonesia dalam menerapkan perlindungan data pribadi yang optimal, dengan mempertimbangkan nilai dan prinsip yang dimilikinya.
Estresores laborales durante el trabajo remoto de docentes peruanos y colombianos
Authors: Santa-Cruz-Espinoza Henry , Castañeda-Paredes Jennifer , Chávez-Ventura Gina , Santa Cruz Espinoza Rossemary , Jiménez García César Augusto
Published: January 2025

La labor docente fue una de las más afectadas por los cambios sufridos en las condiciones de trabajo durante la pandemia por la Covid-19. Estos efectos fueron aún mayores en Latinoamérica, por las carencias propias de los países en vías de desarrollo. El presente estudio tuvo por objetivo describir comparativamente las vivencias durante el trabajo remoto de docentes peruanos y colombianos. El estudio fue trasversal con diseño comparativo y se desarrolló en una muestra no probabilística de 504 docentes (362 peruanos y 142 colombianos). Se utilizó la escala de estresores docentes en tiempos de pandemia, y una ficha sociodemográfica que se administraron de modo online. Los datos se analizaron con la t de Student y la G de Hedges como medida de efecto. Se encontró que los estresores laborales no difieren según sexo; sin embargo, se identificaron diferencias importantes en los estresores relacionados al entorno de trabajo y sobre carga laboral, uso de nuevas tecnologías y aspectos organizacionales de la institución educativa, según país. Estos hallazgos sugieren un mayor impacto negativo de los estresores en docentes que fueron más golpeados por la pandemia.
Influence of Financial Performance on Economic Growth Through The Budget Effectiveness of Regional Government in East Java
Authors: Budi Lutfitra Wisada  , Erwin Saraswati  , Wuryan Andayani
Published: January 2025

This research aims to empirically test the independent variables Autonomy, Liquidity Ratio and Solvency Ratio which are estimated to influence the dependent variable Economic Growth through the Intervening Variable Budget Effectiveness. The data collection method uses the census method by taking all samples of 228 Regency and City Government Financial Reports throughout East Java Province during the 2017-2022 fiscal year. The data analysis technique used in this research is a quantitative method with the Positivism Paradigm. The analytical methods used in this research are Descriptive Statistics, Classic Assumption Test, Coefficient of Determination Test, Regression Analysis, Hypothesis Testing and Sobel Test using SPSS 27. The research results are show that Autonomy and Liquidity Ratios have a positive and not significant effect on Economic Growth partially. Meanwhile, the Solvency Ratio has a negative and insignificant effect on Economic Growth. Autonomy, Liquidity Ratio and Solvency Ratio have a positive and insignificant effect on Economic Growth through the intervening variable budget effectiveness. The Stewardship Theory, which holds that the regional government will endeavor to serve and perform to the best of its ability for the benefit of the larger community, is supported by this research. This research also contributes to providing input to Regional Heads in East Java to be able to manage finances effectively and efficiently and to be able to produce and manage financial resources and PAD independently by making maximum use of existing resources in the region to increase the production of goods and services. society, GRDP and regional economic growth.
Institutional Ownership, Board Diversity, And Carbon Emission Disclosure
Authors: Budanti Ni Putu Lion , Rustiarini Ni Wayan , Putra I Gede Cahyadi
Published: January 2025

Global warming is a crucial issue that is being discussed today. One of the causes of global warming is the development of the industrial sector, which contributes to greenhouse gas emissions. This condition requires public companies to disclose carbon emissions. This study explores the role of institutional ownership and board diversity in carbon emission disclosure (CED) in Indonesia. Board diversity refers to the female and foreign director variables. The study was conducted on manufacturing companies over three years and data analysis using moderated regression analysis. The study results revealed that institutional ownership increased CED. Nevertheless, board diversity testing as a moderation variable provides inconsistent results. The results of the interaction test revealed that the existence of female directors was able to moderate the relationship between institutional ownership and CED. Conversely, foreign directors cannot moderate the relationship between institutional ownership and CED.
Regiones insulares y autosuficientes para reducir la huella ambiental
Authors: Hernández-González Ruperto , Barbero-Barrera Maria del Mar
Published: January 2025

Urge sustituir el actual modelo de construcción con materiales de origen local e innovar tecnológicamente los sistemas de construcción convencionales en busca de la sostenibilidad, la eficiencia y la calidad de los productos. Territorios frágiles como las islas, capaces de albergar hasta el 10% de la población mundial, son una prioridad en el cambio del modelo económico global, con el objetivo de independizarlas del exterior. Las nuevas directrices del marco europeo apuntan hacia la economía circular, la descarbonización y la sostenibilidad. Este cambio requiere un profundo análisis del pasado y de la particularidad del entorno para sentar las nuevas bases del desarrollo futuro.El tejido empresarial del lugar, la tecnificación, la independencia energética y la producción de calidad propia serán los artífices del nuevo cambio. Esto puede aplicarse a cualquier tipo de territorio con el objetivo común de reducir su huella de carbono
An in-depth analysis of the Ångström–Prescott-type solar models: application for Athens, Greece
Authors: Kambezidis Harry D. , Patelis Evangelos , Kavadias Kosmas A.
Published: January 2025

Solar radiation modeling is now a common tool for estimating solar potential around the world. One of these widely used models is the Ångström–Prescott (A–P) formula and all its subsequent modifications. However, Athens lacks an extensive application of A–P. This study aims to fill this gap by estimating solar radiation in Athens using various A–P models and identifying the best-performing models on daily, monthly, and annual time scales. Hourly values of global horizontal irradiance and sunshine duration were sourced from the Actinometric Station of the National Observatory of Athens database for the period 1995–2014. Thirty-two A–P-type models were selected, and a tailored model (MNOA) was developed for Athens. All 33 models were evaluated for their performance on daily, monthly, and annual bases. Advanced statistical metrics such as one-way analysis of variance, F-test, W-test, and post-hoc tests were used for this purpose. On a daily scale, the MNOA model performs best. On a monthly scale, the MRAJ2 model (see the text for description) was found to exhibit superior performance. On an annual scale, none of the selected models demonstrated acceptable performance due to very low R2 values in the regression expressions between estimated and observed solar irradiance. Finally, the MFAO model proposed by the Food and Agriculture Organization was compared with the selected models across all three time scales. On a daily scale, the MFAO showed performance comparable to that of the MNOA model; however, on monthly and annual scales, it exhibited poor performance.
Integrating BIM and IPD for Optimized Design of Residential Buildings: A Case Study in Peru
Authors: Checca Delta S. Tizon , Chambi Ecler Mamani , Vigil Alain J. Espinoza
Published: January 2025

Over the years, the construction sector has used traditional methodologies that often fail to meet established budgets and deadlines, making it imperative to adopt collaborative methodologies such as IPD and BIM. This research evaluates the influence of these methodologies in the design stage of residential buildings, through a case study in Peru managed by an SME. The methodology is divided into three parts: first, a diagnosis of traditional management is carried out through documentary review and semi-structured interviews; second, a proposal for improvement is proposed using tools based on BIM and IPD; third, the proposal is validated through statistical analysis and a validation matrix. Nine typical management problems were identified, such as deficiencies in plans, measurements and budgets, and delays due to inadequate planning. Eight optimization tools are suggested, such as the NEC4 ECC Collaborative Contract, ECD, Revit, Navisworks, early integration of the contractor, ICE Sessions, 3D, 4D and 5D BIM models. The 3D model showed 0.48 interferences per m², the 4D model allowed monitoring the progress of the project, and the 5D model allowed a cost optimization of 5.28%. The profitability analysis showed a return on investment of S/ 3.94 per “sol” invested. The validation of the optimization was demonstrated by the Z Test. The validation matrix highlighted the NEC4 ECC Collaborative Contract and the 3D BIM Model as the most effective tools. In this way, the study contributes to closing the knowledge gap regarding the implementation of BIM and IPD to optimize the management of residential buildings.
Water and Sediment Quantity and Quality Generated in Check Dams as a Nature-Based Solutions (NbS)
Authors: Carrera-Villacrés David Vinicio , Gavilanez Petronio , Brito María José , Criollo Andrés , Chico Alexander Vinicio , Carrera-Villacrés Felipe Benjamin
Published: January 2025

The study evaluates the implementation of check dams as nature-based solutions to address soil erosion, improve sediment quality, and enhance water retention in the Urku Huayku ravine, located on the Ilaló volcano in Ecuador. Weekly water and sediment samples were analysed from 2021 to 2023 to measure critical parameters such as pH, electrical conductivity, nutrient concentrations, and organic matter content. Macroinvertebrates were also collected to assess biodiversity changes, using indices like the Andean Biotic Index (ABI) and the Shannon Diversity Index. Results show significant improvements: water quality remained neutral (average pH 7.06), while sediment organic matter increased substantially from 0.2% in 2021 to 3.2% in 2023. Additionally, biodiversity improved, with a 355.6% increase in macroinvertebrate abundance. Statistical tests confirmed the positive impact of check dams on sediment and water quality. The study also identified potential areas for additional check dam installations using QGIS analysis, emphasising steep slopes as ideal locations. This work demonstrates the effectiveness of check dams in restoring degraded ecosystems and highlights their role in climate change mitigation through enhanced sediment carbon storage and improved biodiversity. Further research is recommended to optimise dam placement and explore additional biodiversity indicators.
Regulatory Genetic Networks by microRNAs: Exploring Genomic Signatures in Cervical Cancer
Authors: Pérez-Plasencia Carlos , Orbe-Orihuela Yaneth Citlalli , Méndez-Herrera Armando , Deas Jessica , Gómez-Cerón Claudia , Jiménez-Wences Hilda , Ortíz-Ortiz Julio , Fernández-Tilapa Gloria , Clemente-Soto Aldo Francisco , Parra-Unda Jesús Ricardo , Velarde-Felix Salvador , Rodríguez-Dorantes Mauricio Rodríguez-Dorantes , Peralta-Zaragoza Oscar
Published: January 2025

With an incidence of over a half million cases every year, cervical cancer remains a major health problem for women worldwide. Epidemiologic and molecular studies have clearly confirmed a causal role of persistent infection with high-risk human papillomavirus in cervical carcinogenesis, affecting several cellular processes. During cervical cancer development, there is genetic instability including disrupted expression of microRNAs and host target genes, which may have multiple implications. Different studies have explored the gene expression profile in cervical cancer using high-throughput technologies, with the goal of identifying microRNA and/or gene molecular signatures from genomics analysis of cervical cancer. However, the results of some studies have been divergent, which may be due to differences in sample collection procedures, high-throughput platforms, data normalization, and filtering methods used in different protocols. Hence, it is imperative to integrate information about diagnostic or prognostic biomarkers from a variety of sources to characterize the molecular mechanisms of regulatory genetic networks in cervical cancer development and progression. In the present review, we analyze the evidence that describes the role of microRNA signatures and target genes in cervical carcinogenesis and cancer progression. The data reviewed support the existence of universal regulatory genetic networks, which operate in cervical pre-cancerous and cancer cells and may represent the main driving forces in this malignancy. This analysis will allow molecular genomic signatures to be put forward as therapeutic targets for cervical cancer, with potential applications in precision medicine.
Wearable Wireless Functional Near Infrared Spectroscopy System for Cognitive Activity Monitoring
Authors: Victorio Mauro , Dieffenderfer James , Songkakul Tanner , Willeke Josh , Bozkurt Alper , Pozdin Vladimir A.
Published: January 2025

From learning environments to battlefields to marketing teams, the desire to measure cognition and cognitive fatigue in real time has been a grand challenge of optimizing the human performance. Near-infrared spectroscopy (NIRS) is an effective optical technique for measuring changes in subdermal hemodynamics, and it has been championed as a more practical method for monitoring brain function, as compared to MRI. This study reports an innovative functional NIRS (fNIRS) sensor that integrates the entire system into a compact and wearable device, enabling long-term monitoring of patients. The device provides unrestricted mobility to the user with Bluetooth connection for settings configuration and data transmission. A connected device, such as a smartphone or laptop equipped with the appropriate interface software, collects raw data, stores, and generates real-time analysis. Tests confirm the sensor is sensitive to oxy- and deoxy- hemoglobin changes at the forehead region, which indicate neuronal activity and provide information for brain activity monitoring studies.
The Long-Term Effects of the Selective Inhibitor of Urate Transporter 1, Dotinurad, on Metabolic Parameters and Renal Function in Patients with Asymptomatic Hyperuricemia
Authors: Yanai Hidekatsu , Hakoshima Mariko , Adachi Hiroki , Katsuyama Hisayuki
Published: January 2025

Background/Objectives: A great number of epidemiological studies have reported that hyperuricemia is associated with the development of hypertension, dyslipidemia, type 2 diabetes, chronic kidney disease (CKD), in addition to metabolic syndrome and insulin resistance. We investigated the effects of long-term treatment with the novel uricosuric drug, a highly selective inhibitor of urate transporter 1 (URAT1), on metabolic parameters and renal function. Methods: We retrospectively picked up patients who had taken dotinurad for the treatment of asymptomatic hyperuricemia, for more than 2 years. We compared metabolic parameters and renal function at baseline with the data at 6, 12, 18, and 24 months after the start of dotinurad. Results: Pharmacologically, dotinurad decreases serum uric acid (UA), by selectively inhibiting URAT1 and decreasing renal reabsorption of UA, which was supported by our result that dotinurad significantly increased urine UA and reduced serum UA. In addition to UA-lowering, dotinurad significantly improved body weight, liver function, serum lipids, and urine albumin. The ATP-binding cassette transporter G2 (ABCG2) regulates renal and intestinal excretion of UA and uremic toxins and strongly affects renal function. Our study also indicates that switching from febuxostat, which inhibits ABCG2, to dotinurad, which does not inhibit ABCG2, was beneficial for maintaining the GFR. Conclusions: Dotinurad may improve obesity, metabolic dysfunction-associated steatotic liver disease (MASLD), and CKD by blocking the entry of UA via URAT1 to adipose tissue, liver, and kidney.
A Novel Thermodynamic Perspective on the Female Reproductive Axis: The Wayback Machine Theory
Authors: Amir Khebbeb
Published: January 2025

Female reproductive physiology is characterized by its unique complexity. Despite advancements in research tools and resources, improvements in women’s healthcare remain limited. This qualitative study focuses on the fundamuntal principles of hemodynamics of the female reproductive system. Using a quasi-experimental setting, we applied several biophysical laws within the broader framework of the second law of thermodynamics: entropy. Contrary to previous findings which focus on the ovary, our results suggest that the myometrium actually plays the main role in regulating cervical mucus secretion, endometrial growth and even ovarian function, positioning the uterus as the key component of menstrual cycle regulation. In the light of our findings, we suggest a new approach in the hierarchy of the hypothalamic-pituitary-gonadal axis and the development of a potential new drug.
Single Crystal Diffraction
Authors: Bruno. Rosaria
Published: January 2025

Advantage of single crystal x ray diffraction is stated, follows the discussion on reached results using this technique and some advertisement for structural good data publication. Laboratory diffractometer and synchrotron in advancement of materials measurements. Gas adsorption and structural characterization, photoinduced crossover spin changing reaction, photoisomerization, photodegradation of organic dye.
Targeting the NLRP3 Inflammasome: Novel Inhibitors for Cardiovascular Disease Management
Authors: Momen Yomna
Published: January 2025

The innate immune system is the first line of defense against pathogens and intracellular danger signals, providing a rapid non-specific response to eliminate the infection and maintain tissue homeostasis. NLRP3 inflammasome as a critical component of the innate immune system plays a pivotal role in the inflammatory response. Many research studies have highlighted the implication of NLRP3 in the pathogenesis of various cardiovascular diseases including atherosclerosis, myocardial infarction, hypertension and heart failure. Activation of NLRP3 elicits a robust inflammatory response represented in proteolytic cleavage and release of pro-inflammatory cytokines such as IL-1β and IL-18, which contribute to the progression of vascular inflammation and myocardial damage. This review aims to comprehensively examine the current understanding of NLRP3 inflammasome activation in cardiovascular diseases, exploring the molecular mechanisms underlying its role in inflammation and tissue injury. Furthermore, we will discuss the evolution of NLRP3 inflammasome inhibitors, focusing on the most novel small synthetic inhibitors of NLRP3 protein and phytoestrogens targeting NLRP3, providing a thorough overview of the potential of targeting NLRP3 as a therapeutic strategy for cardiovascular disease management.
Molecular Identification and Expression Analysis of nod1/2 and tbk1 in Response to Viral or Bacterial Infection in the Spotted knifejaw(Oplegnathus Punctatus)
Authors: Song Yu , Wang Lei , Li Kaimin , Zhang Mengqian , Wang Qingbin , Huang Youhua , Chen Songlin
Published: January 2025

In this study, we investigate the role of Opnod1, Opnod2 and Optbk1 genes in antiviral and antibacterial immunity of spotted knifejaw, and the expression pattern of Opnod1, Opnod2 and Optbk1 mRNA in different tissues and at different time points were validated using qRT-PCR. The results showed that the open reading frame of Opnod1 gene was 2757 bp in length and encoded 918 amino acids, the open reading frame of Opnod2 gene was 2970 bp in length and encoded 990 amino acids,while Optbk1 gene was 2172 bp in length and encoded 723 amino acids. Both Opnod1 and Opnod2 proteins have three conserved domains (CARD, NOD and LRR), and Optbk1 has a S_TKc domain. The results using real-time quantitative PCR showed that Opnod1, Opnod2 and Optbk1 genes were mainly expressed in immune-related tissues of spotted knifejaw, with the highest relative expression of Opnod1 gene in skin tissues, Opnod2 gene in gill tissues and Optbk1 gene in liver tissues. The expression of Opnod1, Opnod2 and Optbk1 genes changed significantly in the immune tissues after infection with SKIV-SD and Vibrio harveyi. In spotted knifejaw kidney cell, the expression of Opnod1, Opnod2 and Optbk1 showed up-regulation after stimulation by poly I:C and LPS in vitro. The results suggest that the NOD1/2-TBK1 signal pathway may play an important role in the resistance of the spotted knifejaw to virus and bacteria, which will provide valuable basis for resistant disease breeding of spotted knifejaw.
A 5-Year Monitoring SLE and Vitamin-D-Supplementation Reveals Significant Reversal in Most SLEDAI Scores and the Need for Objective Testing in Primarily Young Obese Women
Authors: Alshammari Khalid F , Aldugieman Mnieaam. Z , Almansour Mazen A. , Alghassab Ali A. , Said Kamaleldin Bashir
Published: January 2025

Systemic lupus erythematous (SLE) is a devastating autoimmune disease with a se-qualae of clinical manifestations. The inverse relationship between vita-min-D-deficiency (VDD) and SLE is vague. We examined relationships, tests markers, and the consequences of vitamin-D-(VD)-supplementation on SLE over a-5-year (2018-2023)-follow-up using retrospective case-controlled design. Data collected at 2-time-points between 5th and 15th months after the 1st-visit and disease activity measured using SLEDAI-2K score and laboratory records. Out of 1,207 patients, we se-lected 23 complying criteria. Results indicated (39%, n=9) were always positive for the anti-dsDNA and responded to supplementation that lowered SLEDAI score from 10 to 6.8 while equal number of patients (39%, n=9) were also always negative and did not respond. Nevertheless, 13% (n=3) and 9% (n=2) were positive in the 1st and 2nd visits, and while scores increased on both visits, VD doubled in the former and reduced by half in the latter. The antinuclear antibody was inconsistent with 56.5% only were al-ways positive with SLEDAI scores remaining at 5 in both visits with minimal increase in VD (6ng/ml). The clinically consistent signs in both tests, makes it plausible that proteinurea, blood components, or genetically deficient complement interfered in neg-ative cases. Particularly, the rates of platelets, WBC, ESR and the declining CPR with low serum complement levels strongly implied lupus glomerulonephritis for comple-ment activation within the kidney and ceased in serum. These are manifested by ar-thritis, Hematurea, proteinurea, pyurea and are remarkably consistent with selective activities in the primarily young, obese females. The findings have significant implica-tions on age-, gender-, and obesity-specific diagnosis and management. Future large-scale studies are warranted for the young target population with sunlight expo-sure and stable genetics. The major limitation of the study was the sample size due to extreme inclusion criteria and short intervention.
Human Cognitive Architecture as an Intelligent Natural Information Processing System
Authors: Kalyuga Slava
Published: January 2025

Human cognitive architecture represents an intelligent natural information processing system that is described by six operational principles: information store, randomness as genesis, borrowing and reorganizing, narrow limits of change, environmental organizing and linking, and explicit intention to learn principles. The last principle, added recently, is critical, as it distinguishes this system from other, lower-level natural information-processing systems and is responsible for controlled information processing and explicit learning as opposite to implicit cognitive mechanisms of lower-level systems. The paper provides a theoretical overview of the updated model of intelligent natural information processing systems. In this model, the explicit intention to learn principle affects the operation of other principles and is directly related to intelligence as an emergent characteristic of such systems. Human intelligence and explicit, intentional learning (and motivation that is required for such learning to happen) caused the emergence of human culture on a distinct, grand scale in the process of transition from biological to cultural evolution. The paper concludes with some important educational implications emanating from the new model focusing on strengthening human intelligence.
Obstacle Avoidance Using Markov Chains and Fuzzy Control for an Underwater Robot
Authors: Ruiz Holguin Johan , Magid Evgeni , Martínez-García Edgar A.
Published: January 2025

This paper proposes an obstacle avoidance strategy for an underwater robot that integrates Hidden Markov Chains (HMC) with a fuzzy controller. The HMC predicts a vector of future states, leveraging the maximum state probabilities to guide the behavior of the fuzzy controller. The proposed fuzzy controller utilizes five inputs: the robot’s state predictions (crisp sets), instantaneous linear velocity, underwater depth, and yaw and pitch velocities, modeled with Gaussian and sigmoid membership functions. It generates three outputs, also using Gaussian and sigmoid functions, corresponding to the robot’s actuators: the propulsion motor, the steering motor, and the ballasting motor, which operates through an integrated hydraulic piston system. The paper also develops physics-based models for the propulsion, steering, and ballasting systems, alongside sensor fusion models that provide real-time control feedback. Additionally, it presents the robot’s platform and system architecture, designed with multi-threaded, real-time control capabilities. Experimental and simulation results validate the effectiveness of the proposed strategy, demonstrating robust obstacle avoidance in underwater navigation.