bluuebunny/crossref_metadata_2025 huggingface dataset:
Distribution of Homozygosity Regions in the Genome of Kazakh Cattle Breeds
Authors: Beishova Indira , Dossybayev Kairat , Shamshidin Alzhan , Belaya Alena , Bissembayev Anuarbek , Khamzin Kadyrzhan , Kovalchuk Alexandr , Nametov Askar
Published: April 2022

Runs of homozygosity (ROH) are contiguous stretches of homozygous genotypes that are passed from parents to their offspring. ROHs are suitable for determining population history, inbreeding rates, and the genetic relationships between individuals in the populations, as well as to detect candidate genes responsible for economic traits in farm animals. In this study, we observed that the Kazakh white-headed (KWh) cattle breed (ROH n = 55,976) had a higher number of ROH compared to the Auliekol (AK) breed (ROH n = 13,137). When calculating the mean length of ROH, there were considerable differences between Kazakh white-headed (211.59 ± 92.98 Mb) and Auliekol (99.62 ± 46.48 Mb) populations. The maximum length of ROH was higher in Auliekol cattle (510.25 Mb) than in Kazakh white-headed cattle (498.91 Mb). The average inbreeding coefficient rate was equal to 0.084 ± 0.037 in Kazakh white-headed cattle and 0.039 ± 0.018 in Auliekol cattle. The high frequency of genomic regions showed that the strongest patterns were observed on chromosomes 2, 6, and 26 for KWh and 1, 5, and 14 for AK. The estimation of ROH numbers per animal showed that the number of ROH decreased with increasing ROH length in both populations. The genomic inbreeding coefficient of both cattle breeds was calculated based on the ROH, and ancient inbreeding was observed. The harbored genes within ROH islands were associated with meat growth and milk production.
Unusual Focal Lung Uptake without CT Abnormality on a Bone Scan: What Might It Mean?
Authors: Eberlé Marie-Claude , Fersing Cyril , Guillemard Sophie , Ilonca Diana , Guiu Séverine , Deshayes Emmanuel
Published: April 2022

A 48-year-old woman was referred for a bone scan as an assessment of bone metastasis from breast cancer. Surprisingly, two hot spots of lung uptake were present in the left lung without any abnormality on CT slices. No history of pulmonary disease was observed. An optimized CT scan with fine slices performed the same day was strictly normal (without any micronodule). A lung ventilation/perfusion scintigraphy showed no significant perfusion defect. A follow-up bone scan performed eight months later was normal and without any lung uptake. After exclusion of the main etiologies described in the literature, such as amylosis, sarcoidosis, abscess, or hypercalcemia, radiotracer microembolism seems to be the most likely hypothesis in this patient.
A Comprehensive Review of Methods and Equipment for Aiding Automatic Glaucoma Tracking
Authors: Camara José , Neto Alexandre , Pires Ivan Miguel , Villasana María Vanessa , Zdravevski Eftim , Cunha António
Published: April 2022

Glaucoma is a chronic optic neuropathy characterized by irreversible damage to the retinal nerve fiber layer (RNFL), resulting in changes in the visual field (VC). Glaucoma screening is performed through a complete ophthalmological examination, using images of the optic papilla obtained in vivo for the evaluation of glaucomatous characteristics, eye pressure, and visual field. Identifying the glaucomatous papilla is quite important, as optical papillary images are considered the gold standard for tracking. Therefore, this article presents a review of the diagnostic methods used to identify the glaucomatous papilla through technology over the last five years. Based on the analyzed works, the current state-of-the-art methods are identified, the current challenges are analyzed, and the shortcomings of these methods are investigated, especially from the point of view of automation and independence in performing these measurements. Finally, the topics for future work and the challenges that need to be solved are proposed.
Exploration of an Alarm Sensor to Detect Infusion Failure Administered by Syringe Pumps
Authors: Wieduwilt Florian , Grünewald Jasmin , Ctistis Georgios , Lenth Christoph , Perl Thorsten , Wackerbarth Hainer
Published: April 2022

Incorrect medication administration causes millions of undesirable complications worldwide every year. The problem is severe and there are many control systems in the market, yet the exact molecular composition of the solution is not monitored. Here, we propose an alarm sensor based on UV-Vis spectroscopy and refractometry. Both methods are non-invasive and non-destructive as they utilize visible light for the analysis. Moreover, they can be used for on-site or point-of-care diagnosis. UV-Vis-spectrometer detect the absorption of light caused by an electronic transition in an atom or molecule. In contrast a refractometer measures the extent of light refraction as part of a refractive index of transparent substances. Both methods can be used for quantification of dissolved analytes in transparent substances. We show that a sensor combining both methods is capable to discern most standard medications that are used in intensive care medicine. Furthermore, an integration of the alarm sensor in already existing monitoring systems is possible.
Hybrid-Flash Butterfly Optimization Algorithm with Logistic Mapping for Solving the Engineering Constrained Optimization Problems
Authors: Zhang Mengjian , Wang Deguang , Yang Jing
Published: April 2022

Only the smell perception rule is considered in the butterfly optimization algorithm (BOA), which is prone to falling into a local optimum. Compared with the original BOA, an extra operator, i.e., color perception rule, is incorporated into the proposed hybrid-flash butterfly optimization algorithm (HFBOA), which makes it more in line with the actual foraging characteristics of butterflies in nature. Besides, updating the strategy of the control parameters by the logistic mapping is used in the HFBOA for enhancing the global optimal ability. The performance of the proposed method was verified by twelve benchmark functions, where the comparison experiment results show that the HFBOA converges quicker and has better stability for numerical optimization problems, which are compared with six state-of-the-art optimization methods. Additionally, the proposed HFBOA is successfully applied to six engineering constrained optimization problems (i.e., tubular column design, tension/compression spring design, cantilever beam design, etc.). The simulation results reveal that the proposed approach demonstrates superior performance in solving complex real-world engineering constrained tasks.
An Effective Resource Matching Scheme Based on a Novel Unified Descriptive Model for Modern Manufacturing Industry Systems
Authors: Lin Jie , Wu Chunxue , Yared Rami
Published: April 2022

In order to effectively solve the problem of heterogeneous design/manufacturing/service resources and isolation in the whole lifecycle and realize unified description of design/manufacturing/service resources and resource sharing across subjects and stages, this paper proposes a hierarchical and modularized ontology-based resource-unified descriptive model, according to the characteristics of design/manufacturing/service resources. We analyze all kinds of properties of the resources, design a specific descriptive model of ontology, function, and service, ensure the consistency and independence of resource descriptions, and use the OWL (Web Ontology Language) ontology descriptive language and Protégé tools to verify. Then, based on the unified descriptive model, a resource matching method based on multi-level tags is proposed, which matches the task request with the resources in the resource library, selects the resources that meet the task request, and guarantees the resource sharing across subjects and stages. The resource matching work first performs task description and decomposition, and uses information entropy and rough set theory to sort the importance of subtasks, then uses the semantic similarity algorithm to complete multi-level tags’ matching. Finally, two examples are used to prove the feasibility and effectiveness of the experiment.
Using LinkedIn Endorsements to Reinforce an Ontology and Machine Learning-Based Recommender System to Improve Professional Skills
Authors: Urdaneta-Ponte María Cora , Oleagordia-Ruíz Ibon , Méndez-Zorrilla Amaia
Published: April 2022

Nowadays, social networks have become highly relevant in the professional field, in terms of the possibility of sharing profiles, skills and jobs. LinkedIn has become the social network par excellence, owing to its content in professional and training information and where there are also endorsements, which are validations of the skills of users that can be taken into account in the recruitment process, as well as in the recommender system. In order to determine how endorsements influence Lifelong Learning course recommendations for professional skills development and enhancement, a new version of our Lifelong Learning course recommendation system is proposed. The recommender system is based on ontology, which allows modelling the data of knowledge areas and job performance sectors to represent professional skills of users obtained from social networks. Machine learning techniques are applied to group entities in the ontology and make predictions of new data. The recommender system has a semantic core, content-based filtering, and heuristics to perform the formative suggestion. In order to validate the data model and test the recommender system, information was obtained from web-based lifelong learning courses and information was collected from LinkedIn professional profiles, incorporating the skills endorsements into the user profile. All possible settings of the system were tested. The best result was obtained in the setting based on the spatial clustering algorithm based on the density of noisy applications. An accuracy of 94% and 80% recall was obtained.
A Group-Based Droop Control Strategy Considering Pitch Angle Protection to Deloaded Wind Farms
Authors: Liu Hui , Wang Peng , Zhao Teyang , Fan Zhenggang , Pan Houlin
Published: April 2022

To promote the frequency stability of a system with high penetration of wind power integrated into it, this paper presents a systematic frequency regulation strategy for wind farms (WFs). As preparation for frequency response, a coordinated deloading control (CDC) scheme combining the over-speed control (OSC) and the pitch angle control (PAC) methods is proposed for wind turbine generators (WTGs) to preserve power reserve. The novelty lies in the consideration of high wind speed situations and pitch angle protection. Then, a group-based droop control (GBDC) scheme is proposed for a WF consisting of WTGs with the CDC. In this scheme, WTGs are divided into two groups for different controls. To improve the frequency response performance and ensure stable operation, the droop coefficients of the WF, groups, and all WTGs are determined according to their frequency regulation capabilities (FRCs). Moreover, pitch angle protection during the frequency response process is considered in this scheme. The effectiveness of the GBDC scheme is verified by comparing it with several existing droop control schemes in various situations.
Utility-Scale Storage Integration in the Maltese Medium-Voltage Distribution Network
Authors: Micallef Alexander , Spiteri Staines Cyril , Cassar Alan
Published: April 2022

Deployment of renewable energy sources in Malta is limited by grid integration constraints. Photovoltaic (PV) systems pose a significant risk to grid stability due to their inherent intermittency and result in overvoltages at the medium-voltage and low-voltage networks. Investments in utility-scale battery energy storage systems (BESS) will facilitate further deployment of renewables and will help to achieve energy security. This study proposed a novel sizing strategy for utility-scale battery energy storage systems (BESS) based only on technical considerations to find the minimum required storage capacity based on historical electricity demand and PV generation. The modeling and simulation were constrained to a section of the Gozitan 11 kV electrical distribution network and the results showed that the utility-scale storage can reduce the impact of PV systems on the grid infrastructure by avoiding reverse power flows and improve the local energy security by reducing the peak electricity demand. The central BESS and the decentralized coordinated BESS with “equal sizing” stored 3.4 MWh while the decentralized coordinated BESSs with “optimal sizing” stored 5.307 MWh. In all three cases, the evening peak demand was reduced by 30.5% from 2.62 MW down to a defined limit of 1.82 MW. From the results presented in this paper, the “optimal sizing” strategy showed that the BESSs have most benefit when installed next to the local PV generation. Hence, by deploying coordinated utility-scale BESSs sized according to the PV generation potential, it is expected that the penetrations of PV generation can be increased even with the present distribution network infrastructure.
Rapid Quantitation of Coal Proximate Analysis by Using Laser-Induced Breakdown Spectroscopy
Authors: Liu Yulin , Wang Dongming , Ren Xiaohan
Published: April 2022

Proximate analysis of coal is of great significance to ensure the safe and economic operation of coal-fired and biomass-fired power generation units. Laser-induced breakdown spectroscopy (LIBS) assisted by chemometric methods could realize the prediction of coal proximate analysis rapidly, which makes up for the shortcomings of the traditional method. In this paper, three quantitative models were proposed to predict the proximate analysis of coal, including principal component regression (PCR), artificial neural networks (ANNs), and principal component analysis coupled with ANN (PCA-ANN). Three model evaluation indicators, such as the coefficient of determination (R2), root-mean-square error of cross-validation (RMSECV), and mean square error (MSE), were applied to measure the accuracy and stability of the models. The most accurate and stable prediction of coal proximate analysis was achieved by PCR, of which the average R2, RMSECV, and MSE values were 0.9944, 0.39%, and 0.21, respectively. Although the R2 values of ANN and PCA-ANN were greater than 0.9, the higher RMSECV and MSE values indicated that ANN and PCA-ANN were inferior to PCR. Compared with the other two models, PCR could not only achieve accurate prediction, but also shorten the modeling time.
Analysis of Consumer Pro-Environmental Behavior—The Context of Scientific Research
Authors: Balińska Agata
Published: April 2022

The progress of civilization and the related technological development have made electricity a necessary component of production processes and a necessary condition for the functioning of households and individuals [...]
Study on Anode Catalyst Layer Configuration for Proton Exchange Membrane Fuel Cell with Enhanced Reversal Tolerance and Polarization Performance
Authors: Sheng Xia , Ru Chunyu , Zhao Honghui , Jin Shouyi , Wang Bowen , Wang Yupeng , Han Linghai , Jiao Kui
Published: April 2022

Hydrogen starvation leads to the extreme deterioration of fuel cell performance due to the induced voltage reversal and carbon corrosion in the anode catalyst layer (ACL) and gas diffusion layer. In this paper, reversal-tolerant anodes (RTAs) with different ACL configurations are proposed, where IrOx/C is used as a water electrolysis catalyst. Experimental results show that the separate IrOx/C catalyst layer of MEA samples, layered reversal-tolerant catalyst-coated membrane (layered-RTA), and reversal-tolerant gas diffusion electrode (GDE-RTA) significantly enhance the reversal tolerance and cell performance compared to conventional anode and common RTA consisting of a homogeneous catalyst layer mixed with IrOx/C and Pt/C (hybrid-RTA). Of these, GDE-RTA possessed a reversal tolerance time of 86 min, a power density of 1.42 W cm−2, and a minimum degradation rate of 2.4 mV min−1, suggesting it to be the best RTA structure. Cyclic voltammetry and electrochemical impedance spectrum were used to detect the properties of each sample. Additionally, the degradation mechanisms of the three RTAs are thoroughly investigated and discussed by means of microstructural characterization through scanning electron microscopy and transmission electron microscopy. This work provides novel ideas for the fabrication of a robust RTA by tuning the ACL configuration, which is practical for the commercialization of fuel cells.
Simulation of Mass and Heat Transfer in an Evaporatively Cooled PEM Fuel Cell
Authors: Herrendörfer Robert , Cochet Magali , Schumacher Jürgen O.
Published: April 2022

Evaporative cooling is a promising concept to improve proton exchange membrane fuel cells. While the particular concept based on gas diffusion layers (GDLs) modified with hydrophilic lines (HPILs) has recently been demonstrated, there is a lack in the understanding of the mass and heat transport processes. We have developed a 3-D, non-isothermal, macro-homogeneous numerical model focusing on one interface between a HPIL and an anode gas flow channel (AGFC). In the base case model, water evaporates within a thin film adjacent to the interfaces of the HPIL with the AGFC and with the hydrophobic anode GDL. The largest part of the generated water vapor leaves the cell via the AGFC. The transport to the cathode side is shown to be partly limited by the ab-/desorption into/from the membrane. The cooling due to the latent heat has a strong effect on the local evaporation rate. An increase of the mass transfer coefficient for evaporation leads to a transport limited regime inside the MEA while the transport via the AGFC is limited by evaporation kinetics.
Impedance Modeling and Stability Analysis of Three-Phase Four-Wire Inverter with Grid-Connected Operation
Authors: Feng Guoli , Ye Zhihao , Xia Yihui , Huang Liming , Wang Zerun
Published: April 2022

With the continuous penetration and development of renewable energy power generation, distributed grids and microgrids are becoming increasingly important in power systems. In the distribution networks and microgrids, the grid impedance is comparatively large and cannot be ignored. Usually, the parallel compensation is used to improve the grid quality. In these three-phase four-wire power systems, analyzing the impedance characteristics of the grid-connected inverter is vital to carry out the small-signal stability analysis. Thus, it is vital to consider the influence of the zero-sequence component in addition to the positive-sequence component and the negative-sequence component when it comes to analyzing system stability. In this paper, the impedances of three-phase four-wire split capacitor inverter and three-phase four-leg inverter are established. Based on the achieved impedance, the similarities and differences between the impedances of three-phase four-wire split capacitor inverter and impedance of three-phase four-leg inverter are studied. The main difference is reflected in zero-sequence impedance. Additionally, the zero-sequence impedance characteristics and the dominating factors deciding the zero-sequence impedance are analyzed. Then, the stability of the system considering the grid impedance and impedance of three-phase four-wire inverter is investigated by separately considering the stability of the positive–negative-sequence component and the stability of the zero-sequence component. Several cases of small-signal instability caused by the positive–negative-sequence component or zero-sequence component are revealed. The experimental results validate the theoretical analysis.
Examination of Using Aluminum-Foam/Finned-Tube Beds Packed with Maxsorb III for Adsorption Ice Production System
Authors: Elsheniti Mahmoud Badawy , Eissa Mohamed Shaaban , Al-Ansary Hany , Orfi Jamel , Elsamni Osama , El-Leathy Abdelrahman
Published: April 2022

Producing ice using adsorption systems can represent a sustainable solution and meet the recent global environmental regulations as they use natural refrigerants and can be driven by solar energy. However, the beds used in these systems still have low thermal and adsorption characteristics. This study investigates numerically the use of an emerging aluminum foamed bed packed with advanced Maxsorb adsorbent in a two-bed adsorption system and reports cases of performance improvements compared to the classical finned-tube based system used to produce ice. A comprehensive 2-D transient pressure distribution model for the two beds was developed and validated. The model considers the temporal and spatial variations of the two beds’ parameters, while the effect of the thermal mass and heat transfer effectiveness of the condenser and evaporator components are imitated at the boundary conditions for bed openings using two zero-dimensional models. The results show the interrelated effects of varying the cycle times from 400 s to 1200 s with 2, 5, and 10 mm foam thicknesses/fin heights on the overall performance of both systems. The Al-foam based system demonstrated the performance superiority at a 2 mm foam thickness with maximum ice production of 49 kgice/kgads in 8 h, an increase of 26.6% over the counterpart finned-tube based system at a 400 s cycle time. The best COP of 0.366 was attained at a 5 mm foam thickness and 1200 s with an increase of 26.7%. The effective uptake of the Al-foam based system was reduced dramatically at a 10 mm foam thickness, which deteriorated the system performance.
Novel Descriptions of Immature Stages of the Forestry Insect Pest, Yponomeuta meguronis (Lepidoptera: Yponomeutidae), with New Records of Its Natural Enemies
Authors: Kim Sora , Na Sol-Moon , Lee Seunghwan , Hong Ki-Jeong
Published: April 2022

The genus Yponomeuta is widely known as a forestry insect pest group; however, it is extremely difficult to identify it at the species level because of its small size and morphological complexity. Thus far, only a few major species and host plants, as well as natural enemy information, are known through European research within the limited eastern Palearctic region. In this study, Yponomeuta meguronis Matsumura is revealed to be a severe forestry insect pest for Euonymus japonicus Thunb. (Celastraceae) in Korea, which constitutes part of the western Palearctic region. We observed that numerous tiny larvae caused serious damage to its leaves and partially or entirely covered the tree by making communal silk webs. To rapidly and accurately identify this insect pest in the future, new descriptions of immature stages, including larva and pupa, were provided, along with their adult forms, based on ecological photographs and morphological illustrations. Two natural enemies of Y. meguronis were also recognized for the first time in this study: Herpestomus brunnicornis (Gravenhorst) (Hymenoptera: Ichneumonidae) was revealed as a parasitoid, and Xanthandrus comtus (Harris) (Diptera: Syrphidae) was presented as a predator.
Refractometric Detection of Adulterated Milk Based on Multimode Interference Effects
Authors: Fuentes-Rubio Yadira Aracely , Zúñiga-Ávalos Yamil Alejandro , Guzmán-Sepúlveda José Rafael , Domínguez-Cruz René Fernando
Published: April 2022

This paper reports on the refractometric detection of water-adulterated milk using an optical fiber sensor whose principle of operation is based on multimode interference (MMI). The device is manufactured in a simple way by splicing a segment of coreless multimode fiber (NC-MMF) between two single-mode fibers (SMFs); neither functionalization nor deposition of a sensing material is required. MMI takes place in the NC-MMF and, when fed with a broadband spectrum, a transmission peak appears at the output of the MMI device due to its inherent filter-like response, whose position depends on the effective refractive index (RI) of the medium surrounding the NC-MMF. Therefore, when the sensor is immersed in different milk–water mixtures, the peak wavelength shifts according to the RI of the mixture. In this way, adulterated milk can be detected from the wavelength shift of the transmission peak. The system was tested with two commercial brands of milk, and adulterations were clearly distinguished in both cases. In the range of interest, from no dilution up to 50% dilution, the sensor exhibits a linear response with a sensitivity of −0.04251 and −0.03291 nm/%, respectively, for the two samples tested. The measurement protocol is repeatable and allows for locating the peak wavelength within <0.34 nm over several repetitions using different samples with the same concentration. A thermal sensitivity of 0.85 nm/°C was obtained, which suggests that the temperature needs to be maintained as fixed during the measurements. The approach presented can be extended to other scenarios as a quality control tool in beverages for human consumption, showing the advantages of simple construction, high sensitivity, and the potential for real-time monitoring.
Barth Syndrome Cardiomyopathy: An Update
Authors: Pang Jing , Bao Yutong , Mitchell-Silbaugh Kalia , Veevers Jennifer , Fang Xi
Published: April 2022

Barth syndrome (BTHS) is an X-linked mitochondrial lipid disorder caused by mutations in the TAFAZZIN (TAZ) gene, which encodes a mitochondrial acyltransferase/transacylase required for cardiolipin (CL) biosynthesis. Cardiomyopathy is a major clinical feature of BTHS. During the past four decades, we have witnessed many landmark discoveries that have led to a greater understanding of clinical features of BTHS cardiomyopathy and their molecular basis, as well as the therapeutic targets for this disease. Recently published Taz knockout mouse models provide useful experimental models for studying BTHS cardiomyopathy and testing potential therapeutic approaches. This review aims to summarize key findings of the clinical features, molecular mechanisms, and potential therapeutic approaches for BTHS cardiomyopathy, with particular emphasis on the most recent studies.
Genome-Wide Identification of the B-Box Gene Family and Expression Analysis Suggests Their Potential Role in Photoperiod-Mediated β-Carotene Accumulation in the Endocarp of Cucumber (Cucumis sativus L.) Fruit
Authors: Obel Hesbon Ochieng , Cheng Chunyan , Li Ying , Tian Zhen , Njogu Martin Kagiki , Li Ji , Lou Qunfeng , Yu Xiaqing , Yang Zhengan , Ogweno Joshua Otieno , Chen Jinfeng
Published: April 2022

Carotenoids are indispensable to plants and essential for human nutrition and health. Carotenoid contents are strongly influenced by light through light-responsive genes such as B-Box (BBX) genes. BBX proteins, a class of zinc-finger transcription factors, mediate many light-signaling pathways, leading to the biosynthesis of important metabolites in plants. However, the identification of the BBX gene family and expression analysis in response to photoperiod-mediated carotenoid accumulation in cucumber remains unexplored. We performed a genome-wide study and determined the expression of cucumber BBX genes (hereafter referred to as CsaBBXs genes) in the endocarp of Xishuangbanna cucumber fruit (a special type of cucumber accumulating a high level of β-carotene in the endocarp) using an RNA-seq analysis of plants previously subjected to two photoperiodic conditions. Here, 26 BBX family genes were identified in the cucumber genome and named serially CsaBBX1 through CsaBBX26. We characterized CsaBBX genes in terms of their phylogenetic relationships, exon-intron structures, cis-acting elements, and syntenic relationships with Arabidopsis thaliana (L.) Heynh. RNA-seq analysis revealed a varied expression of CsaBBX genes under photoperiod treatment. The analysis of CsaBBXs genes revealed a strong positive correlation between CsaBBX17 and carotenoid biosynthetic pathway genes (phytoene synthase, ζ-carotene desaturase, lycopene ε-cyclase, β-carotene hydroxylase-1), thus suggesting its involvement in β-carotene biosynthesis. Additionally, nine CsaBBX genes (CsaBBX 4,5,7,9,11, 13,15,17 and 22) showed a significant positive correlation with β-carotene content. The selected CsaBBX genes were verified by qRT-PCR and confirmed the validity of RNA-seq data. The results of this study established the genome-wide analysis of the cucumber BBX family and provide a framework for understanding their biological role in carotenoid accumulation and photoperiodic responses. Further investigations of CsaBBX genes are vital since they are promising candidate genes for the functional analysis of carotenoid biosynthesis and can provide genetic tools for the molecular breeding of carotenoids in plants.
Transcriptome Profile of Membrane and Extracellular Matrix Components in Ligament-Fibroblastic Progenitors and Cementoblasts Differentiated from Human Periodontal Ligament Cells
Authors: Mun Seyoung , Kim Seong Min , Choi Min-Jeong , Jang Young-Joo
Published: April 2022

Ligament-fibroblastic cells and cementoblasts, two types of progenitor cells that differentiate from periodontal ligament stem cells (hPDLSCs), are responsible for the formation of the adhesive tissues in the tooth root. Since one of the factors that determines the fate of stem cell differentiation is the change in the microenvironment of the stem/progenitor cells, this study attempted to compare and analyze the molecular differences in the membrane and ECM of the two progenitor cells. Single cells derived from hPDLSCs were treated with TGF-β1 and BMP7 to obtain ligament-fibroblastic and cementoblastic cells, respectively. The transcriptome profiles of three independent replicates of each progenitor were evaluated using next-generation sequencing. The representative differentially expressed genes (DEGs) were verified by qRT-PCR, Western blot analysis, and immunohistochemistry. Among a total of 2245 DEGs identified, 142 and 114 DEGs related to ECM and cell membrane molecules were upregulated in ligament-fibroblastic and cementoblast-like cells, respectively. The major types of integrin and cadherin were found to be different between the two progenitor cells. In addition, the representative core proteins for each glycosaminoglycan-specific proteoglycan class were different between the two progenitors. This study provides a detailed understanding of cell–cell and cell–ECM interactions through the specific components of the membrane and ECM for ligament-fibroblastic and cementoblastic differentiation of hPDLSCs.
History as Philosophy: The Search for Meaning
Authors: Bowden Brett
Published: April 2022

One of the reasons for our interest in the past, or history, is our concern for the future, including the future of our planet and its many and varied inhabitants. It has been suggested that “historians are particularly suited” to exploring and teaching about the future. This suggestion recalls earlier ideas of philosophical approaches to the study of history that sought to find patterns or purpose in history. These approaches are associated with ideas of progress and teleological accounts of history more generally. The underlying philosophical approach to history is a broader search for meaning.
A Needle in a Haystack: Looking for an Early Modern Peasant Who Travelled from Spain to America
Authors: Albiez-Wieck Sarah , Gil Montero Raquel
Published: April 2022

Seventeenth-century travel accounts written by ordinary people are a rarity. In this article, we analyze the unusual travel report by Gregorio de Robles, a Castilian peasant (labrador) who travelled several European empires in Western Europe and America at the end of the seventeenth and the beginning of the eighteenth centuries. The approach we offer is that of a global microhistory. The aim of this article is mainly methodological: we try to delineate the methodological steps we had to undertake to trace Robles in the sources. Looking for an early modern peasant traveler is comparable to searching for a needle in a haystack, but we argue that this endeavor is worthwhile because Robles offers a unique perspective on how ordinary people traveled in early modern times and on imperial frontier zones. We show that his convivial ties and the places he mentions were key elements in the methodology.
Examining English- and Spanish-Speaking Therapist Behaviors in Parent–Child Interaction Therapy
Authors: Green Rosas Yessica , McCabe Kristen M. , Zerr Argero , Yeh May , Gese Kristine , Barnett Miya L.
Published: April 2022

Parent–child interaction therapy (PCIT) is a best-practice treatment for behavior problems in young children. In PCIT, therapists coach parents during in-vivo interactions to strengthen the parent–child relationship and teach parents effective ways of managing difficult child behaviors. Past research has found that different therapist coaching styles may be associated with faster skill acquisition and improved parent engagement. However, most research examining therapist behaviors has been conducted with English-speaking families, and there is limited research examining therapist behaviors when working with Spanish-speaking clients. In this study, English- and Spanish-speaking therapists’ coaching behaviors (e.g., directive versus responsive) were examined, as well as their association with client outcomes, including speed of parental skill acquisition and treatment completion. Results suggested that coaching styles varied significantly between sessions conducted in Spanish versus English. In Spanish sessions, therapists had more total verbalizations than in English sessions and demonstrated higher rates of both total directive and responsive coaching. Responsive coaching was found to predict treatment completion across groups, while directive coaching was not. Directive and responsive coaching were not found to predict the rate of parental skill acquisition. Implications regarding the training of therapists and emphasizing cultural considerations are discussed.
Mental Health and Access to Information in Times of COVID-19: The Role of Social Work
Authors: Romea Ana C. , Valero Diana , Elboj Carmen , Melgar Patricia
Published: April 2022

The confinements and limited social interactions that have derived from COVID-19 have aggravated the situation of people with previous pathologies. As a result, access to health and its rehabilitation or support resources has been limited and redirected toward online care. People with mental health problems have considerably suffered during the pandemic because, for many of them, accessing different information resources through telematic means proved to be a great difficulty in their everyday lives. This exploratory research work aims to establish which elements have successfully facilitated access to online information for people with mental health problems. This is especially urgent in times of COVID-19 when misinformation has significantly harmed this group. To do so, we followed the communicative methodology and held interviews with two professionals and nine users who participated in the case study. The main results show that, in developing digital communicative competencies in accessing information with this group, individualization of care to overcome barriers, the link with social workers as references of truthful information, and the importance of emotional work and interactions are critical elements.
The Impact of the COVID-19 Pandemic on Romanian Postgraduate Periodontal Residency Teaching: Past Experience, Present Imperatives and Future Considerations in a Multicentric Evaluation
Authors: Costea Cristina Andrada , Popescu Dora Maria , Roman Alexandra , Stratul Ștefan-Ioan , Șurlin Petra , Negucioiu Marius , Micu Iulia Cristina , Ciurea Andreea , Lucaciu Patricia Ondine , Lazăr Luminița , Mircioagă Doina Elena , Soancă Andrada
Published: April 2022

The aims of this study were to identify the challenges in periodontology postgraduate residency programs during the COVID-19 pandemic by identifying the modifications of educational instruments, to evaluate the impact of hybrid education on periodontology postgraduate programs in terms of resident-centred outcomes, and to evaluate the education efficiency of an innovative teaching approach. Resident doctors from three Romanian dental faculties were included in study groups based on the intensity of clinical training. A web-based questionnaire was used to collect information on residents’ perception about teaching activity. Important educational changes were identified. Moreover, residents learned a periodontal procedure through online training and then performed it on preclinical models three times. The working times were recorded. Statistical analysis was performed. Resident doctors were unsatisfied with clinical practice during the pandemic year, but they positively valued the development of online courses. Learning efficiency improved by repeating the same procedure on preclinical models, as proved by the significant decrease of the working times. E-learning was appreciated as an important component of the new hybrid teaching approach. Reorganization and further emphasis on both preclinical and medical practice, targeted to aid residents perform more accurate and efficient procedures, are recommended.
Intercultural Competence Predicts Intercultural Effectiveness: Test of an Integrative Framework
Authors: Schelfhout Stijn , Vandecasteele Robin , De Maesschalck Stéphanie , D’hondt Fanny , Willems Sara , Derous Eva
Published: April 2022

Why does someone thrive in intercultural situations; while others seem to struggle? In 2014, Leung and colleagues summarized the literature on intercultural competence and intercultural effectiveness into a theoretical framework. This integrative framework hypothesizes that the interrelations between intercultural traits, intercultural attitudes and worldviews, and intercultural capabilities predict the effectiveness with which individuals respond to intercultural situations. An empirically verified framework can contribute to understanding intercultural competence and effectiveness in health care workers, thus contributing to more equity in health care. The present study sets out to test this integrative framework in a specific health care context. Future health care practitioners (N = 842) in Flanders (Belgium) were questioned on all multidimensional components of the framework. Structural equation modeling showed that our data were adequate to even a good fit with the theoretical framework, while providing at least partial evidence for all hypothesized relations. Results further showed that intercultural capabilities remain the major gateway toward more effective intercultural behavior. Especially the motivation and cognition dimensions of cultural intelligence seem to be key factors, making these dimensions an excellent target for training, practical interventions, and identifying best practices, ultimately supporting greater intercultural effectiveness and more equity in health care.
Prevalence and Molecular Characterization of Methicillin-Resistant Staphylococci Recovered from Public Shared Bicycles in China
Authors: Xu Zhen , Chen Liqin , Chen Xiaowei , Tang Amei , Huang Dengmin , Pan Qin , Fang Zhongze
Published: April 2022

Millions of public shared bicycles (PSBs) have been launched in China, and PSBs are a potential reservoir of antimicrobial-resistant staphylococci. However, no national data to elucidate the dissemination, antimicrobial resistance and genotypes of staphylococci has been recovered from public shared bicycles located in different cities in China. Antimicrobial susceptibility, SCCmec types and sequence types of staphylococci were determined. A total of 146 staphylococci were recovered in this study, and 87% staphylococcal isolates were resistant to at least one antibiotic. In total, 29 (20%) staphylococcal isolates harbored mecA gene, and SCCmec types were determined as follows: SCCmec type II (n = 1), IV(n = 3), V (n = 4), VI (n = 1), VIII (n = 2), A/1 (n = 6), A/5 (n = 2), C/1 (n = 2), C/2 (n = 1), C/3 (n = 1), (n = 5) and Pseudo (ψ)-SCCmec (n = 1). Sequence types of 16 Staphylococcus epidermidis were determined, including ST10, ST17, ST59, ST60, ST65, ST130, ST184, ST262, ST283, ST337, ST360, ST454, ST567, ST820, ST878 and ST934. PSBs are a reservoir of diverse antimicrobial-resistant staphylococci, and staphylococcal species differences were observed in isolates that were recovered from public shared bicycles in the south and north of China. PSBs are a source of antimicrobial resistance and genetic diverse staphylococci.
Exclusive Breastfeeding Duration and Perceptions of Infant Sleep: The Mediating Role of Postpartum Anxiety
Authors: Davies Siân M. , Todd-Leonida Bethany F. , Fallon Victoria M. , Silverio Sergio A.
Published: April 2022

(1) Background: Existing literature has identified associations between exclusive breastfeeding, maternal mental health, and infant sleep. This study aims to examine these relationships simultaneously and consider the mediating role of postpartum anxiety. (2) Methods: Participants completed validated measures of postpartum anxiety, infant sleep, and reported exclusive breastfeeding duration. Postpartum mothers with infants between six and twelve months (n = 470) were recruited to a cross-sectional online survey containing a battery of psychological measures. (3) Results: Correlation analyses examined the relationships between the predictor (exclusive breastfeeding duration), outcome (perceptions of infant sleep), and mediator (postpartum anxiety). Exclusive breastfeeding duration was significantly associated with postpartum anxiety (p < 0.05), postpartum anxiety was significantly associated with perceptions of infant sleep (p < 0.001), and exclusive breastfeeding duration was significantly associated with perceptions of infant sleep (p < 0.001). A simple mediation model was conducted, showing a significant total (B = −0.029 (0.010), p < 0.05), direct (B = −0.035 (0.009), p < 0.001), and indirect effect (B = 0.007, SE = 0.003, 95% CI = 0.000 to 0.014) of exclusive breastfeeding duration on perceptions of infant sleep via postpartum anxiety. (4) Conclusions: Associations were identified between exclusive breastfeeding duration, postpartum anxiety, and perceptions of infant sleep. The mediation model suggests postpartum anxiety may be an underlying mechanism which reduces exclusive breastfeeding duration and negatively affects maternal perceptions of infant sleep quality.
Exploring Preventive Healthcare in a High-Risk Vulnerable Population
Authors: Amboree Trisha L. , Montealegre Jane R. , Fujimoto Kayo , Mgbere Osaro , Darkoh Charles , Wermuth Paige Padgett
Published: April 2022

This study describes preventive care behaviors and explores opportunities to deliver preventive sexual healthcare to a high-risk vulnerable population. Data from the National HIV Behavioral Surveillance (NHBS) system high-risk heterosexuals (HET) cycle (2019) in Houston, Texas, was used to describe preventive care utilization and assess the relationship between healthcare utilization and sociodemographic characteristics. More than 47% reported having no usual source of healthcare, and 94.6% reported receiving no non-HIV STI testing in the past 12 months. Additionally, many sociodemographic factors were associated with healthcare utilization and having a usual source of healthcare. Future efforts should be targeted at increasing preventive healthcare utilization among high-risk vulnerable populations as well as implementing more preventive sexual healthcare services in the community health centers where these populations most frequently encounter healthcare.
Associations between Allergic and Autoimmune Diseases with Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder within Families: A Population-Based Cohort Study
Authors: Li Dian-Jeng , Tsai Ching-Shu , Hsiao Ray C. , Chen Yi-Lung , Yen Cheng-Fang
Published: April 2022

Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) are commonly comorbid with allergic and autoimmune diseases in children. The aim of the current study was to investigate the association between children’s and first-degree relatives’ (i.e., mother, father, and full sibling) allergic and autoimmune diseases and children’s ASD and ADHD. We enrolled participants from Taiwan’s Maternal and Child Health Database. We used the Cox regression model to examine the associations of familial, siblings’ and children’s allergic and autoimmune diseases with children’s ASD and/or ADHD. In total, we included 1,386,260 children in the current study. We found the significant association between familial allergic or autoimmune disease and development of ASD or ADHD among children. We also identified the predominant impact of familial aggregation on the above associations. The associations between some parental diagnoses of autoimmune or allergic diseases in children’s ASD and/or ADHD were stronger in mothers than those in fathers. Early assessment of the possibility of ASD and ADHD is required for children who have a parent with an allergic or autoimmune disease.
Rasch-Validated Italian Scale for Diagnosing Digital Eye Strain: The Computer Vision Syndrome Questionnaire IT©
Authors: Cantó-Sancho Natalia , Ronda Elena , Cabrero-García Julio , Casati Stefano , Carta Angela , Porru Stefano , Seguí-Crespo Mar
Published: April 2022

The use of digital devices affects eye health; this can influence the performance of workers. To assess this impact, validated patient-reported outcome questionnaires are needed. The purpose of this study was to validate the psychometric properties of the Italian version of the Computer Vision Syndrome Questionnaire (CVS-Q©) using Rasch analysis. Two hundred and forty-one Italian workers completed an ad hoc questionnaire on anamnesis and exposure to digital devices, and the Italian version of the CVS-Q©. Subsequently, a battery involving three clinical ocular surface and tear tests was performed. The reliability and validity of the scale was assessed using the Andrich Rating Scale Model, and the prevalence of computer vision syndrome (CVS) was calculated. A good fit of both items and persons to the predictions of the Rasch model was observed, with acceptable reliability, unidimensionality, and no or minimal severe differences as a function of gender or age; moreover, good test–retest repeatability, adequate values of sensitivity, reliability, and area under the curve, and adequate construct validity based on clinical tests were obtained. Workers with a questionnaire score ≥ 7 were found to present with CVS. The prevalence of CVS was 76.6%. The CVS-Q IT© is a valid and reliable scale to assess CVS in Italian workers who use digital devices.
Knowledge, Readiness and Barriers of Street Food Hawkers to Support the Single-Use Plastic Reduction Program in Northeast Malaysia
Authors: Abdullah Nur Baizura Aini , Yaacob Nor Azwany , Ab Samat Razan , Ismail Ahmad Filza
Published: April 2022

This study aimed to determine the knowledge, readiness, and barriers among street food hawkers to support the single-use plastic reduction program. A cross-sectional study was performed involving 440 night market food street hawkers from five districts in Kelantan, Malaysia selected through proportionate random sampling from 17 night market locations. The majority of the respondents had good knowledge level, 60% of respondents were ready to support this program, and 73% of them responded that barriers had low influence on them. Social media was the most popular information source utilized to obtain plastic usage information. Age, readiness to change, and significant barriers, were found to be associated with better knowledge. Male food hawkers and food hawkers that received information from social media and official sources were more ready to support single-use plastic reduction program. Proper strategies which incorporate more environmental knowledge, identify, and address the barriers may enhance the readiness to support this pro-environmental behaviour.