bluuebunny/crossref_metadata_2025 huggingface dataset:
Mitigation of 3-MCPDE and GE in palm oil in Indonesia
Authors: Elisabeth Jenny
Published: October 2023

Among consumed-vegetable oils, RBDPO (refined, bleached and deodorized palm oil) is indicated containing higher level of 3-MCPDE and GE, which have been classified as potentially carcinogenic and/or genotoxic to human. Those contaminants in RBDPO are formed during deodorization process with high temperature and also correlate with chloride content and quality of CPO as raw material.  The maximum limit for 3-MCPDE and GE content in vegetable oil has been set at 2500 and 1000 µg kg-1, and as low as 750 and 500 µg kg-1 when used for production of baby food and cereal-based foods for infants and young children. The mitigation of 3-MCPDE and GE in RBDPO is quite challenging for palm oil refineries in producing a good quality of palm oil in term of sensory, stability, safety, and nutritional value, especially in Indonesia.  It has been proven that modification of conventional refining process can reduce the 3-MCPDE and GE content. They are including pre-treatment of CPO by water washing to reduce the chloride content, alkali neutralization to remove any acids present in the oil prior to deodorization, using neutral bleaching earth, adding antioxidants after bleaching to reduce free radical-mediated formation of 3-MCPDE and GE, lowering the deodorization temperature with a longer time, and even double bleaching and/or double deodorization of the palm oil.  Post-refining treatment using specific adsorbents is also applied to remove the 3-MCPDE  and GE. However, palm oil  refineries  have  to  apply combination of several mitigation strategies to adequately reduce the levels of 3-MCPDE and GE, including using good quality of CPO with low FFA, chloride, and oxidized components content.
Digital Pixel Based Event Vision Sensor with Simultaneous Event and Intensity Outputs
Authors: Tianye Wen , Lu Jian , Liu Caihong , Liu Xiaoguang
Published: October 2023

In this letter, we report the design of a low-power event-based vision
sensor (EVS) digital pixel in a 3D-stacked 45-nm backside illumination
CMOS process. The design uses in-pixel analog-to-digital converters and
memory to store digitized light intensities. By using a bit comparator
to compare digital intensity values of the same pixel in the time
domain, the high-fidelity event stream and intensity information from
the same pixel can be generated simultaneously. The power consumption of
the proposed digital EVS pixel can be as low as 10 nW/pixel. The EVS
sensor can achieve a maximum event rate of 260 Meps.
The role of pacemaker in the prevention of atrial fibrillation in patients with sick sinus syndrome
Authors: Polat Fuat , Yaylak Barış , Onuk Tolga , Eren Semih , Mollaalioğlu Feyza , Akyüz Şükrü
Published: October 2023

Objective: This retrospective study examined the relationship
between atrial pacing parameters and atrial fibrillation (AF) occurrence
in patients with sick sinus syndrome (SSS) who received dual-chamber
pacemakers. Methods: Sixty SSS patients who underwent dual
pacemaker implantation were studied. Demographics, clinical data, and
device information were collected, and patients were followed for up to
2 years post-implantation. Statistical analyses assessed the association
between atrial pacing parameters and AF development. Receiver operating
characteristic (ROC) analysis identified potential predictors of AF,
focusing on atrial pacing frequency and mode switch episodes.
Results: Higher atrial pacing frequency significantly reduced
AF risk at all time points (p<0.001), while lower pacing rates
did not correlate with AF incidence. The number of atrial premature
beats and mode switch episodes showed significant correlations with AF
occurrence in the early post-implantation period but lost significance
over time. Multivariable Cox regression analysis indicated that the
number of atrial premature beats had no significant effect on AF
development. However, an inverse relationship was observed between
atrial pacing frequency and AF occurrence in the first and third months
post-implantation. Conclusion: Maintaining a higher atrial
pacing frequency emerges as a valuable strategy to reduce AF risk in
dual-chamber pacemaker recipients with SSS. Notably, atrial premature
beats and mode-switching episodes primarily influenced AF risk during
the early post-implantation phase. This underscores the importance of
monitoring and optimizing atrial pacing parameters, especially in the
initial stages following pacemaker implantation, for effective AF
management in SSS patients.
Analysis and evaluation of seed kernel oil content and fatty acid components of Acer truncatum in Central China
Authors: Han Minhao , Yan Liping , Liang Yan , Wang Yinhua , Ren Fei , Wu Dejun
Published: October 2023

In order to screen out the high-oil Acer truncatum germplasm
resources so as to improve the yield and value of seed oil, this
experiment was carried out by analyzing and evaluating a total of 70
samples from natural populations of A. truncatum in nine Central
Plains of China, the results were subjected to nested ANOVA and
correlation analyses, as well as a comprehensive evaluation of the
various groups using principal component analysis and the affiliation
function method. The findings demonstrated that the 70 samples ranged in
seed kernel oil content from 14.43% to 50.11% (average 33.11%), and
that the major fatty acid fractions had coefficients of variation that
ranged from 24.13% to 33.40%, with differences between them being
significant. According to correlation analysis, latitude, temperature,
and precipitation had a greater impact on the seed kernel oil content
than they did on the relative content of fatty acid fractions. Altitude,
temperature, and precipitation were the primary causes of changes in the
content of fatty acid fractions. The principal component analysis
reduced the nine indexes to two principal components with a cumulative
contribution rate of 84.29%, and ranked them according to the
comprehensive evaluation value obtained from the principal component
analysis and the transformation of the affiliation function. The
analysis screened out the ten germplasm samples with the highest
comprehensive quality and the three samples with the highest
comprehensive evaluation value.
Wheat Fusarium Head Blight (FHB) Disease Severity Estimation using UAV Multispectral Imagery and Machine Learning
Authors: Janjua Ubaid ur Rehman , Maimaitijiang Maitiniyazi , Millett Bruce , Billah Mohammad Maruf , Shires Madalyn , Yabwalo Dalitso , Sehgal Sunish K. , Ali Shaukat
Published: October 2023

Wheat is an important primary crop that nourishes billions of people
worldwide. Wheat diseases, particularly Fusarium head blight (FHB)
disease, often have a severe effect on wheat yield in terms of both
quantity and quality posing potential threats to the health of humans
and livestock. Traditional methods such as field surveys for monitoring
and assessing wheat diseases are time-consuming, costly and inefficient.
In recent years, remote sensing approaches, particularly aerial imaging
using Unmanned Aerial Vehicles (UAV), have become invaluable tools for
rapid field scouting at larger scale, as well of crop growth and health
status. This study aims to investigate the potential of combining
high-resolution UAV multispectral imagery with machine learning (ML)
methods for the estimation of FHB disease severity. Two experimental
wheat fields were established at Volga, South Dakota, USA, in 2022. The
severity of FHB disease was assessed and rated in the fields; and
synchronous UAV flights were conducted to collect multispectral imagery.
Canopy spectral and texture features were derived from the UAV
multispectral imagery and used as input variables for ML models to
predict FHB disease severity levels. Both classification and regression
approaches were applied to estimation FHB severity using ML models such
as Random Forest, Support Vector Machine, and Deep Neural Networks. The
results show that both canopy spectral and texture features are
important indicators for monitoring the severity of FHB wheat disease.
Furthermore, the use of UAV remote sensing, combined with ML-based
modeling, is a sustainable approach for rapid and accurate detection of
wheat FHB disease severity.
Low-temperature dielectric and impedance properties of Ba1-xSrxTiO3 and BaTi1-xTaxO3 ceramics
Authors: Wang Depeng , Niu Ruifeng , Cui Liqi , Wang Weitian
Published: October 2023

In this work, two series of BaTiO3-based ceramics, Ba1-xSrxTiO3 (x = 0, 0.2,
0.4, 0.6, 0.8) and BaTi1-xTaxO3 (x = 0.03, 0.06, 0.075, 0.09, 0.1), were
synthesized by using standard solid-state reaction method at 1350 ?C, and
then sintered at 1400 ?C for 10 h in air. Frequency-dependent dielectric and
impedance properties were investigated at low temperature range of 100-300K.
The changes in dielectric properties of the Ba1-xSrxTiO3 ceramics are
believed to originate from the phase transition due to the different A-site
Sr2+ doping concentration. The local electron-pinned defect-dipole effect is
responsible for the enhancement of dielectric constant observed in the
B-site Ta5+ doped BaTi1-xTaxO3 ceramics. The complex impedance analysis was
used to discern the temperature and frequency dependence of grains and grain
boundaries responses. The results suggest that A- and B-site doped BaTiO3
ceramics can be applied for different dielectric devices at low
temperatures.
No clinically relevant difference in patient-reported outcomes between the direct superior approach and the posterolateral or anterior approach for primary total hip arthroplasty: analysis of 37,976 primary hip arthroplasties in the Dutch Arthroplasty Registry
Authors: Van Dooren Bart , Peters Rinne M , van Steenbergen Liza N , Post Richard A J , Ettema Harmen B , Bolder Stefan B T , Schreurs B Willem , Zijlstra Wierd P
Published: October 2023

Background and purpose: The direct superior approach (DSA) is a modification of the posterolateral approach (PLA) for total hip arthroplasty (THA). Patient-reported outcome measures (PROMs) of the DSA have not been investigated previously using nationwide data. Our aim was to assess PROMs after THA using the DSA compared with the PLA and, secondarily, with the anterior approach (DAA).Patients and methods: In this population-based cohort study we included 37,976 primary THAs performed between 2014 and 2020 (PLA: n = 22,616; DAA: n = 15,017; DSA: n = 343) using Dutch Arthroplasty Registry data. PROMs (NRS pain, EQ-5D, HOOS-PS, and OHS) were measured preoperatively, and at 3 and 12 months postoperatively. Repeated measurements were analyzed using mixed-effects models, adjusted for confounders, to investigate the association between surgical approach and PROMs over time.Results: From baseline to 3 and 12 months, improvements for NRS pain scores, EQ-5D, and OHS were comparable for the DSA compared with the PLA or DAA. No difference was found in HOOS-PS improvement 3 months postoperatively between DSA and PLA (–0.2, 95% confidence interval [CI] –2.4 to 1.9) and between DSA and DAA (–1.7, CI –3.9 to 0.5). At 12 months postoperatively, patients in the DSA group had improved –2.8 points (CI –4.9 to –0.6) more in HOOS-PS compared with the DAA, but not with the PLA group (–1.0, CI –3.2 to 1.1).Conclusion: Our study showed no clinically meaningful differences between the DSA and either PLA or DAA.
Federated learning for generating synthetic data: a scoping review
Authors: Little Claire , Elliot Mark , Allmendinger Richard
Published: October 2023

IntroductionFederated Learning (FL) is a decentralised approach to training statistical models, where training is performed across multiple clients, producing one global model. Since the training data remains with each local client and is not shared or exchanged with other clients the use of FL may reduce privacy and security risks (compared to methods where multiple data sources are pooled) and can also address data access and heterogeneity problems. Synthetic data is artificially generated data that has the same structure and statistical properties as the original but that does not contain any of the original data records, therefore minimising disclosure risk. Using FL to produce synthetic data (which we refer to as "federated synthesis") has the potential to combine data from multiple clients without compromising privacy, allowing access to data that may otherwise be inaccessible in its raw format.
ObjectivesThe objective was to review current research and practices for using FL to generate synthetic data and determine the extent to which research has been undertaken, the methods and evaluation practices used, and any research gaps.
MethodsA scoping review was conducted to systematically map and describe the published literature on the use of FL to generate synthetic data. Relevant studies were identified through online databases and the findings are described, grouped, and summarised. Information extracted included article characteristics, documenting the type of data that is synthesised, the model architecture and the methods (if any) used to evaluate utility and privacy risk.
ResultsA total of 69 articles were included in the scoping review; all were published between 2018 and 2023 with two thirds (46) in 2022. 30% (21) were focussed on synthetic data generation as the main model output (with 6 of these generating tabular data), whereas 59% (41) focussed on data augmentation. Of the 21 performing federated synthesis, all used deep learning methods (predominantly Generative Adversarial Networks) to generate the synthetic data.
ConclusionsFederated synthesis is in its early days but shows promise as a method that can construct a global synthetic dataset without sharing any of the local client data. As a field in its infancy there are areas to explore in terms of the privacy risk associated with the various methods proposed, and more generally in how we measure those risks.
THE URGENCY AND REVITALIZATION OF THE DEVELOPMENT OF THE ECONOMIC SYSTEM IN INDONESIA THROUGH THE MANAGEMENT OF THE SCIENTIFIC APPROACH OF FIQH PESANTREN
Authors: Rusli Moch. , Khullatil Mardliyah Ikhda
Published: October 2023

Economics has become an essential science for the resilience of a country and has become an endless discussion. The Prophet exemplified economic activity before the prophetic era, and economic studies emerged in fiqh learning which was divided into muamalah fiqh. Muamalah fiqh studies can be found in Islamic boarding schools, but the snag is part of the final chapter in one book study, so the depth of the material still needs to be improved. The main objective of this research is to explain the urgency and revitalization of Islamic boarding school fiqh as the basis for economic activity in Indonesia so that the Indonesian economy can survive and be sustainable. This research is qualitative descriptive research with a data source in the form of a document review. Data analysis techniques use Creswell's theory: of organizing, transcribing, and analyzing data. The results show that pesantren, with all the potential they have, can revitalize Islamic boarding schools with economics using the scientific approach to jurisprudence that has been studied. This revitalization is essential to be carried out comprehensively following current economic developments while still using the sources of the Qur'an and Hadith.
Pendampingan Mahasiswa KKN Terhadap Literasi Baca Tulis Siswa Sekolah Dasar Di Desa Lembung Kecamatan Galis-Pamekasan
Authors: Agus budiharto  , Tjitra Ramadani
Published: October 2023

Rendahnya minat baca dan kemampuan menulis siswa merupakan alasan utama dilaksanakannya kegiatan ini. Sasaran kegiatan adalah 13 siswa SDN Lembung kecamatan Galis-Pamekasan. Sekolah dasar merupakan pendidikan awal untuk pengembangan kemampuan literasi anak, karena di fase awal anak akan diberikan kegiatan menstimulasi perkembangan kemampuan mendengar, berbicara, membaca dan menulis. Sehingga permasalahan yang dimiliki oleh mitra saat ini adalah bagaimana mitra meningkatkan literasi baca dan tulis bagi anak-anak usia 7-11 tahun. Tujuan dari pengabdian ini adalah untuk meningkatkan literasi baca tulis anak usia sekolah di desa Lembung kecamatan Galis-Pamekasan. Pengabdian dilakukan di Lembung kecamatan Galis-Pamekasan dilaksanakan pada bulan Desember 2022. Metode pelaksanaan yang dilakukan dalam pengabdian ini berupa metode observasi, sosialisasi, dan pendampingan dan evaluasi. Hasil yang diperoleh dari program literasi baca tulis anak usia sekolah ini adalah meningkatnya kemampuan membaca dan kemampuan menulis anak.
Identifikasi Keanekaragaman dan Sebaran	Jenis Burung untuk Pengembangan Ekowisata Birdwatching di TWA Jering Menduyung
Authors: Sonia Anna , Jeniver Jely , Ade Nur Milah Siti , Irwanto Riko
Published: October 2023

Taman Wisata Alam Jering Menduyung memiliki potensi kenaekaragaman jenis burung yang tinggi dan dapat dikembangkan sebagai salah satu ekowisata birdwatching. Namun, data mengenai keanekaragaman dan sebaran jenis burung di kawasan ini masih sangat sedikit dan belum terdokumentasi dengan baik. Penelitian ini bertujuan untuk mengetahui keanekaragaman dan sebaran jenis burung, serta jalur yang potensial untuk dikembangkan sebagai ekowisata birdwatching. Penelitian dilaksanakan pada Agustus sampai Oktober 2022. Metode yang digunakan adalah metode eksplorasi pada jalur 1 (hutan dataran rendah) dan jalur 2 (mangrove), serta metode IPA (Index Point of Abundance) pada jalur 3 (pantai). Hasil menunjukkan terdapat 39 spesies burung dari 11 ordo dan 24 famili, dengan nilai indeks keanekaragaman Shannon-Wiener 2,981. Jalur 1 (hutan dataran rendah) sangat berpotensi untuk dikembangkan sebagai lokasi birdwatching dengan jumlah spesies burung sebanyak 30 jenis, sedangkan jalur 2 (mangrove) dan jalur 3 (pantai) dengan jumlah spesies burung sebanyak 13 jenis termasuk jalur berpotensi untuk pengamatan burung.
Acción coagulante de la tuna, tara, mashua en el tratamiento de aguas del Rio Ichu, Huancavelica 2020
Authors: Charapaqui Anccasi Juan , Tafur Anzualdo Vicenta Irene
Published: October 2023

La presente investigación tuvo como objetivo determinar la incidencia de la acción coagulante de la tuna, tara y mashua en el tratamiento de aguas delRío Ichu en Huancavelica. Se realizó el monitoreo de calidad de agua, en los laboratorios de Universidad Nacional Agraria La Molina [UNALM]. Los parámetros medidos fueron conductividad eléctrica, sólidos disueltos totales, pH, color, turbidez y volumen de lodos; continuando las pruebas de jarras con agua sintética de turbiedad de 160 UNT. En la primera fase se realizó las pruebas utilizando el sulfato de aluminio como coagulante primario y en una segunda fase se usó el sulfato de aluminio como coagulante primario y agregando la goma de tara, tuna y mashua como polímeros naturales para mejorar su rendimiento. Cuyo resultados son, la tasa de decantación con el coagulante sulfato de aluminio fue 29 m3/m2//d y la velocidad de sedimentación 0.034cm/s; agregando al agua el ayudante de coagulante goma de tara resulto 34 m3/m2//d y 0.039 cm/s, adicionando a la muestra de agua la goma de tuna resultó 30 m3/m2/d y 0.035 cm/s, finalmente agregando el almidón de mashua resultó 68 m3/m2/d y 0.079 cm/s, respectivamente. Se concluye que la acción coagulante de la tara, tuna y mashua, permiten potabilizar el agua para el consumo humano.
ANALISIS KANDUNGAN METABOLIK SEKUNDER PADA DAUN KENIKIR (Cosmos Caudatus Kunth.) DENGAN PELARUT METANOL, ETANOL, DAN ETIL ASETAT
Authors: Masitah Masitah , Pribadi Teguh , Pratama Mohammad Indra , Harrist Reynaldi Ferdhani , Sari Prita Asminitya , Dianita Feby , Setiawan Volta Kellik
Published: October 2023

Cosmos Caudatus Kunth. is one of the most commonly found medicinal plants.   Cosmos leaves contain phytochemical compounds such as terpenoids, fatty acids, flavonoids, alkaloids, tannins, and saponins. This study aims to determine the effect of differences in methanol, ethanol, and ethyl acetate solvents on the phytochemical tests of  Cosmos leaf samples. The study was conducted in the Biology Education Laboratory, Faculty of Teacher Training and Education, Mulawarman University, as well as the Organic Chemistry Laboratory, Faculty of Mathematics and Natural Sciences, Mulawarman University. Qualitative phytochemical screening is conducted by assessing the solubility qualities of the substances. The findings from the examination of secondary metabolic chemicals indicate that the methanol extract derived from Cosmos leaves comprises alkaloids, triterpenoids, flavonoids, phenolics, and quinones. While the ethanol extract of Cosmos leaves contains alkaloids, flavonoids, saponins, phenolics, and quinones. There is an ethyl acetate extract of Cosmos leaves, alkaloids, steroids, flavonoids, phenolics, and quinones.
PERSEPSI GURU TERHADAP IMPLEMENTASI KURIKULUM MERDEKA DALAM PEMBELAJARAN BIOLOGI SMA DI KABUPATEN OGAN ILIR
Authors: Kumala Diana , Hidayat Saleh , Saputri Wulandari , Astriani Meli , Suhartati Suhartati
Published: October 2023

This study aims to describe teachers' perceptions of the implementation of the independent curriculum in biology learning activities in Ogan Ilir District. The method used is the descriptive-qualitative method. The research sample consisted of eight biology teachers in four high schools (SMA) in Ogan Ilir District who had implemented the independent curriculum. Data on teacher perceptions were obtained through observation and interviews using observation sheet instruments, interview instrument grids, and interview instrument question sheets. The collected data was then analyzed with a qualitative descriptive analysis. The results showed that all participants had good perceptions regarding the implementation of the independent curriculum in schools and acknowledged the advantages contained in the independent curriculum, but only some of the participants were able to consistently apply it in learning activities. This is because participants experience difficulties in designing independent curriculum teaching modules, compiling assessments, implementing learning models, using independent teaching platforms, and preparing intracurricular reports and P5 report cards. These findings indicate that socialization and training on the independent curriculum need to be maximized again by including consistent mentoring programs for teachers so that they can consistently implement the independent curriculum in the teaching and learning process.
KEPRAKTISAN ENSIKLOPEDIA FAMILI ANNONACEAE DI KEBUN RAYA BANUA UNTUK MELATIHKAN KETERAMPILAN BERPIKIR KRITIS MAHASISWA
Authors: Nida Nida , Zaini Muhammad , Kaspul Kaspul
Published: October 2023

Students' critical thinking skills are still very low. Development research is carried out to improve the quality of the product under development, namely the encyclopedia. An encyclopedia is learning material that includes descriptions and pictures to make topics clearer. Each statement is listed in alphabetical order for ease of use. This study aims to describe the viability of the Annonaceae family in the Botanical Garden of Banua. This study uses the developmental research type of instructional design research with Tessmer's formative assessment design. The personality test subjects were four students and the small group test subjects were four students who took the Phanerogamae course. Data were obtained from different research instruments on the practicality of content and the practicality of expectations. The results of the encyclopedic study of the family Annonaceae at the Botanical Garden of Banua on the practicality of the contents received a good category, because it received a very good category for its structure, attractiveness, and practicality because it is easy to use, and has received positive feedback from students.
Modern Javanese Canned Gudeg Viewed from Cultural, Food Safety, and Visual Design Perspectives
Authors: Utami Maya Putri , Maulana Anand Reyna , Dukut Ekawati Marhaenny , Wulandari Dyah
Published: October 2023

Gudeg, a traditional culinary dish from Yogyakarta, Indonesia, is prepared by cooking young jackfruit with coconut milk and spices. It is commonly served with rice, eggs, chicken, and sambal goreng krecek, which is a spicy blended chili cooked with savory edible soft cowhide. Gudeg is interesting to discuss as it holds a rich history and is a cultural legacy that has been passed down through generations in Indonesia. Over time, gudeg producers have introduced an innovation of providing a visually attractive label on canned packages.  This gives reason for research on gudeg using a cultural, food safety, and visual design perspective. The research found that culturally gudeg was the staple for the Mataram Kingdom army to survive the battle against enemies who wanted to colonialize the area. Next, the food safety test revealed that canned Gudeg Bagong had a microbial count of 1.3 x 10-1 CFU/ml, while canned Gudeg Andrawina Loka had a count of 2.4 x 10-2 CFU/ml. The findings demonstrated that the microbiological analysis met the standards set by Ministry of Health Regulation No. 416/MENKES/PER/IX/1990 and Indonesian Food and Drug Authority Regulation No. HK.00.06.1.S2.4011. Lastly, through visual design research, it was found among others that local and foreign tourists prefer to see the actual photo display of gudeg set with its jackfruit, egg, chicken, and sambal goreng krecek contents.
Red Clay Mini Bricks with Nano-Bentonite (Clamib-Naben): Materials in Early Learning
Authors: Ibrahim Norizzati
Published: October 2023

The Ministry of Energy, Science, Technology, Environment, and Climate Change (MESTECC) is concerned about a downward trend (from 48 % in 2012 to 44 % in 2019) of students in schools pursuing Science, Technology, Engineering, and Mathematics (STEM) subjects in schools and higher education institutions. This downward trend may be related to the thinking of the younger generation, who consider engineering courses quite challenging due to the nature of the courses, which are considered "difficult courses". Therefore, the purpose of this research is to explore the effect of implementing red Clay Mini Bricks with Nano-Bentonite (ClaMiB-NaBen) materials on anxiety towards engineering among students at the preschool level. A cooperative learning method was utilised among students in developing building models using ClaMiB-NaBen. In order to achieve the objectives of the study, a total of 50 students from pre-school were selected. Observations and pre- and final tests were used to collect empirical data based on practical activities in the class. The data were described using frequency, mean, and standard deviation. The pre-test showed that the majority of students were not interested in the field of engineering. However, the post-test results revealed a significant increase in interest in this field. Therefore, ClaMiB-NaBen is expected to be able to change the perception of the younger generation to be more interested in engineering, which is in line with the Sustainable Development Goals (SDG) of Malaysia that are to be achieved by 2030, as all countries are racing to produce new science and technology that is sustainable, affordable, and safe.
Cines expandidos
Authors: De Carvalho Victa , Mutchinick Melissa
Published: October 2023

Partiendo de una concepción plural de la noción de dispositivo, referida simultáneamente a las formas expresivas, al espectador y a un régimen de creencias siempre circunstanciado, lo que se presenta decisivo en este abordaje son las posibilidades de reinvención, reconfiguración y expansiones de los dispositivos. En este caso se revisan las experimentaciones que engloba un conjunto de manifestaciones denominadas cine expandido.
A COMPARATIVE ANALYSIS BETWEEN TRADITIONAL AND ALTERNATIVE EARLY CHILDHOOD EDUCATION, SUCH AS THE MARIA MONTESSORI METHOD, REGGIO EMILIA PEDAGOGICAL APPROACH
Authors: Avetisyan Mariana , Konjoyan Hasmik
Published: October 2023

This article aims to conduct a comparative analysis between early childhood traditional education and alternatives in primary education, such as the Maria Montessori method and Reggio Emilia approach.  This article will be relevant and advisable for educators and parents to understand the key differences between each approach. There is no doubt that early childhood education plays an essential role in educating young minds. The question is how to find the best way to educate young children, what to choose: teacher-centered or child-centered models of teaching? Furthermore, from a parental view, the question is not only which method works the best, but also which one is more beneficial for “My Child”. Parents have difficulty choosing the right teaching option specifically for their children, which would help them become successful members of modern society in the future.

Taking into consideration our teaching experience of more than twenty-five years, along with researching many pedagogical and educational books and articles, we came to an interesting conclusion about both – traditional and alternatives in teaching young minds. Alongside, we discovered that no matter how beneficial is the true idea of any teaching method, unfortunately, not every school is a true barrier to the philosophy, theory, and teaching approach behind the school’s name brand.
Receptor-based approaches and therapeutic targets in Alzheimer’s disease along with role of AI in drug designing: Unraveling pathologies and advancing treatment strategies
Authors: Patwekar Mohsina , Patwekar Faheem , Shaikh Daniyal , Fatema Shaikh Rohin , Aher Sunil J. , Sharma Rohit
Published: October 2023

Alzheimer’s disease (AD) is a prevalent cause of dementia in the elderly, characterized by progressive cognitive decline and neurodegeneration. This review focuses on the etiology of AD, the role of various receptors [TNF (Tumor necrosis factor) receptor, nAChR (Neuronal nicotinic acetylcholine receptors), NMDARs (N-Methyl-D-aspartate receptors), APOE (Apolipoprotein E) receptor, and amyloid-beta receptor], and risk factors contributing to its development. AD progresses through mild, moderate, and severe stages, each exhibiting distinct symptoms. The hallmark pathologies are neurofibrillary tangles and amyloid plaques, comprised of hyperphosphorylated tau protein and amyloid-beta peptides, respectively. Current pharmacotherapeutic options alleviate symptoms but lack a complete cure. To address the challenges in developing effective AD treatments, researchers have turned to artificial intelligence (AI) and computational approaches in drug design. AI techniques, including machine learning and molecular docking, enable the analysis of large datasets and prediction of molecular interactions between potential drug candidates and target receptors. Virtual screening and molecular modeling aid in identifying novel therapeutic compounds. Predictive modeling and optimization algorithms optimize drug properties and predict efficacy. AI also facilitates the repurposing of existing drugs by analyzing their interactions with AD-related receptors and pathways. Clinical trial optimization using AI algorithms enhances patient selection, treatment monitoring, and outcome prediction. Integrating AI into AD drug design holds tremendous promise for accelerating the discovery of effective interventions. By leveraging AI’s capabilities, researchers can efficiently analyze extensive data, predict drug-target interactions, and optimize drug properties, leading to the identification of novel AD treatments. However, further research and validation are needed to translate AI-driven drug design approaches into clinically viable solutions for AD patients. Through continued advancements in AI and collaborative efforts, the development of targeted and advanced therapies for AD is within reach.
El turismo en la economia española y la irrupcion de una pandemia
Authors: García Pozo Alejandro Francisco
Published: October 2023

Desarrollo expositivo de la Lección Inaugural impartida el dia 25 de septiembre de 2020 en el Paraninfo de la Universidad de Málaga con motivo de la inauguración del curso académico 2020/2021, en donde se hace un estudio de la influencia de la pandemia del COVID-19 en un sector tan estratégico para la economia española y andaluza como es el turístico.
Derinkuyu dry bean irrigation planning in semi-arid climate by utilising crop water stress index values
Authors: Uçak Ali B. , Atılgan Atılgan , Korytowski Mariusz , Kocięcka Joanna , Liberacki Daniel , Stachowski Piotr , Saltuk Burak , Rolbiecki Roman
Published: October 2023

This study was conducted to determine crop water stress index (CWSI) values and irrigation timing in the case of Derinkuyu dry bean ( Phaseolus vulgaris L.). In 2017, dry beans were grown as the main crop according to the field design consisting of plots divided into randomised blocks. Irrigation treatment comprised full irrigation (I100) and irrigation issues with three different levels of water stress (I66, I33, I0). This study applied 602 mm of water under the I100 irrigation. The yield of Derinkuyu dry beans was equal to 3576.6 kg∙ha –1 in I100 irrigation. The lower limit (LL) value, which is not necessary for the determination of CWSI, was obtained as the canopy–air temperature difference ( Tc – Ta) versus the air vapour pressure deficit ( VPD). The upper limit (UL) value, at which the dry beans were wholly exposed to water stress, was obtained at a constant temperature. The threshold CWSI value at which the grain yield of dry beans started to decrease was determined as 0.33 from the measurements made with an infrared thermometer before irrigation in I66 irrigation treatment. As a result, it can be suggested that irrigation should be applied when the CWSI value is 0.33 in dry beans. Furthermore, the correlation analysis revealed a negative correlation between grain yield and crop water stress index and a positive correlation between yield and chlorophyll content. According to variance analysis, significant relationships were found between the analysed parameters at p ≤ 0.01 and p ≤ 0.05.
Adrenomedullin induces cisplatin chemoresistance in ovarian cancer through reprogramming of glucose metabolism
Authors: Dou Lei , Lu Enting , Tian Dongli , Li Fangmei , Deng Lei , Zhang Yi
Published: October 2023

Background and Objectives

The metabolic network of cancer cells has been reprogrammed – relying more on aerobic glycolysis to gain energy, which is an important reason for drug resistance. Expression of adrenomedullin (ADM) in ovarian cancer tissues is related to resistance to platinum-based drugs. In view of this, we intended to investigate the correlation between ADM and glucose metabolism reprogramming of tumor cells to clarify the possible mechanism of ADM-induced ovarian cancer cisplatin resistance through glucose metabolism reprogramming.

Methods

Epithelial ovarian cancer (EOC) cell viability and apoptosis were determined. Different gene expression and protein levels were detected by real-time revere transcription polymerase chain reaction and western blotting. Oxygen consumption rate (OCR) and extracellular acidification rates (ECARs) were measured.

Results

ADM expression was upregulated in cisplatin-resistant EOC cells. ADM attenuated cisplatin-inhibited cell survival and cisplatin-induced apoptosis in sensitive EOC cells; knockdown of ADM enhanced cisplatin chemosensitivity of cisplatin-resistant EOC cells. ADM enhanced glycolysis in cisplatin-sensitive EOC cells; knockdown of ADM significantly inhibited glycolysis in cisplatin-resistant EOC cells. ADM significantly upregulated pyruvate kinase isozyme type M2 (PKM2) protein level, the key enzyme during glycolysis; PKM2 inhibitor significantly abolished the ADM-improved cell survival and ADM-inhibited apoptosis.

Conclusion

ADM promoted proliferation and inhibited apoptosis of ovarian cancer cells through reprogramming of glucose metabolism, so as to promote cisplatin resistance. The study is expected to identify multidrug resistance markers of ovarian cancer and provide a target for the prevention and treatment of ovarian cancer, which is important for clinical translational research.
Serum myoglobin modulates kidney injury via inducing ferroptosis after exertional heatstroke
Authors: Luan Yingyi , Huang Enping , Huang Jiajia , Yang Zhenjia , Zhou Zhipeng , Liu Yan , Wang Conglin , Wu Ming
Published: October 2023

Background and Objectives

Myoglobin released by rhabdomyolysis (RM) is considered to be involved in pathogenesis of kidney disease caused by crush injury, but whether high level of serum myoglobin predisposes patients to acute kidney injury (AKI) and its molecular mechanisms are still unclear in exertional heatstroke (EHS). We aimed to determine the association and potential mechanism of myoglobin and AKI, and further investigate the targeted therapeutic agents for myoglobinemia.

Methods

Serum myoglobin concentrations in patients with EHS were measured at admission, 24 h and 48 h after admission and discharge. The risk of AKI at 48 h was the primary outcome; the secondary outcome was composite outcome events with myoglobin levels and AKI at discharge and death at 90 days. In experimental studies, we further investigated the mechanisms of human kidney proximal tubular (HK-2) cells that were exposed to human myoglobin under heat stress conditions and the effect of baicalein.

Results

Our measurements showed that the highest myoglobin quartile (vs. the lowest) had an adjusted odds ratio (OR) of 18.95 (95% confidence interval [CI], 6.00–59.83) for AKI and that the OR (vs. quartile 2) was 7.92 (95% CI, 1.62-38.89) for the secondary outcome. The survival rate of HK-2 cells treated with myoglobin under heat stress was significantly decreased, and the production of Fe2+ and reactive oxygen species (ROS) was markedly increased, accompanied by changes in ferroptosis proteins, including increased p53, decreased SLC7A11 and GPX4, and alterations in endoplasmic reticulum stress (ERS) marker proteins. Treatment with baicalein attenuated HK-2 cell ferroptosis induced by myoglobin under heat stress through inhibition of ERS.

Conclusions

High myoglobin was associated with AKI in the EHS, and its mechanisms involved ERS-associated ferroptosis. Baicalein may be a potential therapeutic drug for the treatment of AKI in patients with high myoglobin induced by rhabdomyolysis following EHS.
The crucial role of gadolinium-enhanced MRI in a case of amaurosis fugax – a case report and literature review
Authors: Manea Maria Mirabela , Dragoş Dorin , Dobri Ana-Maria , Ghenu Maria Iuliana , Stoican Iulia-Cosmina , Enache Iulia-Ioana , Tuta Sorin
Published: October 2023

Optic perineuritis is the inflammation of the optic nerve sheath. This affliction can lead to visual field impairment and other signs and symptoms related to the orbital space, such as pain, disc edema, ophthalmoplegia, proptosis. However, not all patients present with such suggestive symptoms, requiring a thorough assessment. We report the case of a young male admitted to our hospital for recurrent episodes of monocular blindness. Amaurosis fugax is a well-known presentation of transient ischemic attacks (TIA) and it was ruled out. Gadolinium-enhanced MRI revealed a typical aspect of optic perineuritis. It was mandatory to consider all possible causes of secondary optic perineuritis as they all represent serious clinical conditions, even if the idiopathic form is more frequent. The clinical and paraclinical evaluation of the patient excluded an underlying disease and primary optic perineuritis was diagnosed. Corticosteroid therapy is usually curative and a course of methylprednisolone was initiated for our patient with good outcome. However, response to treatment is not diagnostic as both primary and secondary optic perineuritis are normally responsive, hence thorough differential diagnosis is necessary.
The Main Determinants of the Government Expenditure: A Case Study of Côte D’ivoire
Authors: Mohsen Adel Shakeeb
Published: October 2023

Based on the importance of government expenditure in supporting economic growth in the country, the main objective of this study is to investigate the determinants of government expenditure in Cote d’Ivoire over the period 1980-2020. To achieve the objective, this study examines the effect of external debt, national income, inflation, and population on government expenditure, by using the ADF unit root test, Johansen cointegration test, Granger causality test, and CUSUM test. Results from the Johansen cointegration test indicated that there are long-run relationships among the variables. Government expenditure is positively related to external debt, national income, and population, but it is negatively related to inflation. The population has the biggest effect on government expenditure. The Granger causality test shows that there is a unidirectional short-run causality relationship running from external debt to government expenditure, but there is no evidence of any short-run causality relationship between national income, inflation, population, and government expenditure. On the other hand, there are bidirectional long-run causality relationships between inflation, population, and government expenditure, and unidirectional long-run causality relationships running from external debt and national income to government expenditure in Côte d’Ivoire. Lastly, the CUSUM test indicated that there are no structural changes in the model. The study recommends that the government should use government expenditure more efficiently in improving the infrastructure and creating an attractive investment climate, as well as upgrading the quality of human capital by improving the education system, health services, and the standard of living.
Impacts of the Use of Brazilian Fauna and Flora in Food and Medicinal Use
Authors: Da Costa Matheus Gomes , Araújo Raiana Cristina Simião , Carvalho Aldenor de Sousa , Brito Eliete da Silva , Aguiar João Vitor Castro , Oliveira Rainara Ribeiro , Da Mata Raylane Rocha , De Almeida Ricardo Santos , Rocha Thiara Lopes
Published: October 2023

Objective: To describe the main repercussions of the use of Brazilian fauna and flora for food and medicinal purposes.
 
Method: This is an integrative literature review with a descriptive and qualitative approach. Searches were conducted in the Virtual Health Library system of the Ministry of Health using the following descriptors: medicinal teas, phytotherapeutic medication, and medicinal plants. Initially, 415 results were found without filters, and after applying the filters, the number of studies reduced to 74. From these, the titles from the database search were read, resulting in a final sample of only 15 articles for qualitative synthesis.
 
Results and conclusion: Through the conducted searches, it was found that the use of plants as medicines dates back to prehistoric times when humans began to utilize nature to cure their illnesses. Currently, medicinal plants are widely used in different parts of the world and are important sources of new bioactive molecules that can be used in the development of new medicines, dietary supplements, and natural cosmetics.
 
Research implications: The study highlights the richness and diversity of Brazilian flora, emphasizing the importance of preserving these natural resources. This is crucial for the conservation of unique plant and animal species in Brazil.
 
Originality/value: The study emphasizes the need for policies for the preservation and sustainable use of Brazilian fauna and flora resources. This is essential to ensure the survival of these species and to provide safe and effective treatments for people.
La portée de la Commission de vérité et de réconciliation dans les contextes francophones canadiens
Authors: Wiscutie-Crépeau Nancy , Ng-a-Fook Nicholas , Joncas Jo Anni , Pageau Laurie
Published: October 2023

Ce numéro spécial fait état de la portée des appels à l’action de la Commission de vérité et de réconciliation (CVR) du Canada dans les contextes francophones en éducation. Cette contribution présente des travaux de recherche émergents réalisés au Québec et en Ontario de même que des réflexions d’ordre théorique proposées par des chercheurs en contextes québécois, albertain et saskatchewanais. Ils portent sur les possibilités et les limites des appels à l’action de la CVR en contextes francophones, notamment quant aux enjeux en éducation d’autochtonisation, de réconciliation, de décolonisation, d’identités ainsi qu’à ceux relatifs aux politiques éducatives et de curriculum afin de mieux comprendre la position particulière des communautés francophones dans le projet de colonialisme de peuplement canadien.
The life and work of an artist-teacher in the Southern Urals as a manifestation of Social and Professional Heroism (based on biographical data about Victoria Mukhametovna Pitirimova)
Authors: Ivlev Nikita Nikolaevich
Published: October 2023

The relevance of this study is due to the fact that the images of heroes reflect the values of society and realize the function of transmitting these values from generation to generation. The images contribute to the formation of ideological attitudes of society, and are a of spiritual support for both an individual and entire multiethnic nation. Outstanding artists are not only masters, but also teachers, mentors who convey not only knowledge, but also a worldview, national consciousness and ideals, the position of a citizen, educate spiritual and moral principles. The purpose of the study is the life and creative path of V. M. Pitirimova as a manifestation of the professional and social heroism of the artist-teacher in the difficult socio-economic conditions of life in Russia at the end of the XX-beginning of the XXI century. The object of research is the biography, the path of creative and professional development of Victoria Mukhametovna Pitirimova. The subject of the research is artistic and pedagogical techniques and methods used by Pitirimova Victoria Mukhametovna, her moral guidelines. The research is based on an interview with the main character of the study – V. M. Pitirimova, in which she gives an interpretation of her key creative and pedagogical achievements. In the course of the study, historical-systemic, historical-genetic, historical-biographical and diachronic methods were applied. Based on the materials obtained in the course of the study, an attempt is made to present the main milestones of the life and work of the artist and teacher Pitirimova Victoria Mukhametovna in the most complete and consistent way.The scientific novelty of the research lies in the introduction into scientific circulation of previously unexplored and unpublished information about the creative and professional achievements of Victoria Mukhametovna.
On the Historiography of the Stalinist Modernization of the Regional Peasant Society in the USSR (based on the materials of Mordovia)
Authors: Nad'kin Timofei Dmitrievich , Martynenko Aleksandr Valentinovich , Mal'chenkov Denis Petrovich
Published: October 2023

The object of the study is the historiographical aspects of the modernization of the peasant society of Russia during Stalinism, which is usually identified with the continuous collectivization and dispossession of the late 1920s – early 1930s. The subject of the study is the corpus of scientific works on Stalinist agrarian modernization in the Mordovian region during the first five-year plans, the first of which appeared in the second half of the 1950s, analyzed taking into account the change of ideological paradigms in Russian historical science in the early 1990s. Within the framework of this study, the authors tried to trace the transformation of assessments of Stalin's agrarian modernization in the scientific community of regional historians on the historiographical material of Mordovia. The main conclusions of this study concern sufficiently high degree of elaboration of the issues under consideration in the regional historiography of the Republic of Mordovia. At the same time, despite the growing attention to the pre-war agrarian modernization in the post-Soviet period, a number of problematic issues have been identified that require more in-depth study. Among them: the economic efficiency of collective farms and state farms organized in the late 1920s – the first half of the 1930s, the degree of mechanization of agricultural production, solving the problem of providing the growing urban population with food, changes in the socio-cultural appearance and public attitudes of the multinational and multi-confessional peasantry of the Mordovian Region.