bluuebunny/crossref_metadata_2025 huggingface dataset:
Gyula és térsége turisztikai jelentősége a 2020. évben meghatározott új desztinációs szerkezetben
Authors: Kis Fruzsina , Bagdi Róbert
Published: October 2022

A hazai turizmus irányítási és szervezeti rendszerét 2016-ban alapjaiban újították meg, amelynek számos új eleme volt. Ezek közül csak a 2016-2017 folyamán lehatárolásra került öt kiemelt turisztikai fejlesztési térség meghatározását említjük meg, amelyek a hazai turizmusfejlesztés új, térbeli kereteit adták. 2020 őszén a desztinációs rendszert továbbfejlesztették, ami nemcsak az elnevezések felülvizsgálatát jelentette, de azt is, hogy tizenegy turisztikai térséget határoztak meg, úgy, hogy a korábbi öt mellé hat újat jelöltek ki. Az új térségek közül a Gyula és térsége turisztikai térség áll a legkevesebb, mindössze két településből (Gyula és Békéscsaba). A desztinációs kijelölést a 2019-ben realizált 613 ezer vendégéjszaka mindenképpen indokolta, amiből 520 ezer volt a belföldi vendéghez köthető. Tanulmányunkban a turisztikai térség legfontosabb attrakciót és az azokról alkotott véleményt próbáljuk meg meghatározni, a Gyulára érkezett vendégek kérdőív általi megkérdezése alapján. A Gyulai Vár, a Várfürdő és az Almásy-kastély bizonyult a legnépszerűbbnek Gyulán, de a Százéves Cukrászda ismertsége is magas volt (a válaszadók háromnegyede említette). A megkérdezettek 57,7%-a legalább kettő okot megjelölt, ami miatt felkereste a térséget. A válaszadók 35,2%-a pedig már legalább háromszor tekintette meg a gyulai vár kiállításait.
PKM PENGEMBANGAN INDUSTRI TENUN LURIK MELALUI MODEL PEMASARAN BERBASIS WEB DI CAWAS KABUPATEN KLATEN
Authors: Aryani Y. Anni , Setiawan Doddy , Gantyowati Evi , Trinugroho Irwan
Published: October 2022

This activity will be carried at Mlese Cawas Klaten, Central Java. This area has potential that has been passed down from generation to generation to produce traditional striated fabrics and processed products. The people living around the area are mostly weavers and weaving workers. The village has the potential to develop lurik weaving skills. The main problems that exist for the craftsmen include management problems, especially marketing problems, production processes that are not optimal and have not carried out efficiency. This service activity will be carried out using several approaches, including conducting training in management and skills, training on web-based marketing methods for craftsmen and applying skir technology for efficiency of the production process.
Practical training as a factor of student’s professional adaptation
Authors:   St. Petersburg State Institute of Culture, Brezhneva Valentina V.
Published: October 2022

The requirements to the practical training of students set under the federal laws and their realization are examined, i. e. general curriculum including lectures, seminars, practicals, course and graduate qualification works, field internship. The focus is also made on the extra-curricular activities, e.g. volunteering, involvement in projects, creative endeavours, aimed at developing professional competences in students.
Area information resources of I. Franko Crimean Republican Universal Scientific Library
Authors:   I. Franko Crimean Republican Universal Scientific Library, Videnkina Natalya M. , Kondratenko Olesya O. ,   I. Franko Crimean Republican Universal Scientific Library
Published: October 2022

The key vectors of area studies and services of the Crimean central library under regional and interregional projects in the web-environment are discussed. These efforts are to expand the traditional methods of area information popularization, which has practical evidences. The study is of practical importance.
On interdisciplinary character of bibliology: From bibliologos to neurobibliology
Authors:   Library of the Russian Academy of Sciences, Leonov Valery P.
Published: October 2022

The modern approach to the concept of bibliology is examined and evaluated. The importance of the book studies on the intersection of neurosciences and the humanities knowledge is emphasized. The concept of neurobibliology is substantiated as an interdisciplinary scientific area at the interface of bibliology and theory of cognitive processes. He also suggests to establish an analytical center for bibliology.
Several aspects of cultural and recreational activities in sci-tech libraries
Authors:   Russian National Public Library for Science and Technology, Platonova Maria A.
Published: October 2022

New elements of cultural and recreational activities e.g. those related to the pieces of art, in the practice of sci-tech libraries are discussed. The arguments why this is the special vector in library services, are presented.
Blockchain technology in libraries
Authors:   G. V. Plekhanov Russian University of Economics, Podoprigora Vladimir N. ,   International Research Institute for Advanced Systems
Published: October 2022

Transfer from the Internet of information to the Internet of values based on the blochain-based trust protocol offers new opportunities for preservation and management of intellectual products. However, the advantages of blockchain-technology, e.g. distributed ledgers, absence of single point of failure, smartcontracts, etc., have not got into the focus of libraries. E-library technologies are reviewed in brief. The efforts to acquire blockchain-based decentralized information systems are described. Possible scenarios for using blockchain-technologies in the libraries of future are discussed.
Factores en la adherencia del tratamiento fisioterapéutico en un instituto nacional de rehabilitación
Authors: Moya Nolli Carmen Rosana , Gordillo Sotomayor Flor de María , Santiago Bazán Cristhian
Published: October 2022

Objetivo: Determinar los factores en la adherencia del tratamiento fisioterapéutico en un instituto de rehabilitación peruano. Material y métodos: Estudio descriptivo-correlacional de corte transversal realizado en una muestra de 110 pacientes atendidos en el Departamento de la Unidad Motora y Dolor del Instituto Nacional de Rehabilitación. Se aplicó un muestreo probabilístico y una encuesta, con un instrumento conformado por 20 preguntas para determinar factores intrínsecos y extrínsecos a la adherencia del tratamiento, cuya confiabilidad fue 0,814, según alfa de Cronbach. Resultados: El 49,1 % son del sexo femenino y son adherentes al tratamiento fisioterapéutico. Asimismo, los factores intrínsecos y extrínsecos están relacionados con la adherencia fisioterapéutica en los pacientes atendidos. Conclusión: La adherencia al tratamiento no tiene que ver solo con el fisioterapeuta, sino también con cualquier otro profesional; entendiendo el compromiso real, sincero y honesto del paciente, y considerando los consejos del fisioterapeuta.
Sistem Pengelolaan Tugas Akhir Mahasiswa secara Online (Studi Kasus pada Jurusan Teknik Informatika STMIK-AMIK Riau)
Authors: - Erlin , Andesa Khusaeri
Published: October 2022

Tugas akhir adalah proyek terakhir yangharus dikerjakan oleh mahasiswa untukmenyelesaikan pendidikan mereka di sebuahperguruan tinggi. Dalam prosesnya, mahasiswadibimbing oleh dua orang dosen pembimbingyang ditunjuk oleh jurusan yang sesuai denganbidangnya. Namun masalah yang sering munculadalah pembimbing tidak memiliki cukup waktuuntuk memberikan arahan dan bimbingan untukbanyak mahasiswa bimbingannya. Selanjutnya,setiap proses bimbingan mahasiswa diwajibkanmembawa draft tugas akhir dalam bentuk bahancetak sekali pakai yang akhirnya menjadilimbah ketika penyusunan skripsi selesai. SistemPengelolaan Tugas Akhir Mahasiswa secaraOnline (SPTAMO) dirancang untuk menanganikeragaman tugas akhir mahasiswa STMIKAMIK Riau yang bervariasi dan komplek. Sistemini menyediakan suatu proses secarasentralisasi dan dapat diakses kapan saja dandimana saja secara bersamaan olehpenggunanya. Hal ini tidak memerlukankesesuaian waktu antara mahasiswa denganpembimbingnya dalam memberikan bimbingandan konsultasi terhadap tugas akhir. Kerangkadari sistem pengelolaan tugas akhir mahasiswasecara online ini juga dilengkapi denganpemberian saran oleh sistem kepada jurusantentang penunjukkan dosen pembimbing yangpaling sesuai bidangnya dengan judul proposaltugas akhir mahasiswa dengan menggunakanmetoda vector space model. Sistem inimencakup mulai dari pengajuan judul, reviewjudul, seminar proposal, penunjukanpembimbing, tugas pembimbing, prosesbimbingan dan penilaian akhir yang semuanyadiproses secara online
Sistem Penatausahaan dan Pelaporan Bendahara Pengeluaran Satuan Kerja Perangkat Daerah (SKPD) pada Dinas Pertanian Kota Pekanbaru
Authors: Erlinda Susi , Agustina Tri , - Hamdani
Published: October 2022

Sistem penatausahaan dan pelaporan bendahara pengeluaran satuan kerja perangkat daerah yang berjalan pada Dinas Pertanian Kota Pekanbaru selama ini telah mengunakan komputerisasi akan tetapi penatausahaan dan pelaporan tersebut tidak menggunakan program yang terstruktur hanya menggunakan fasilitas pengetikan pada program Microsoft Excel. Hal ini menyebabkan penatausahaan, pelaporan dan pengarsipan yang dilakukan oleh bendahara pengeluaran tidak efisien dan tidak efektif. Adapun tujuan yang diharapkan dalam pembuatan sistem ini adalah membuat sebuah perangkat lunak untuk Penatausahaan dan Pelaporan Bendahara Pengeluaran Satuan Kerja Perangkat Daerah (SKPD) sehingga menghasilkan penatausahaan dan pembuatan laporan pertanggungjawabannya secara cepat, akurat dan efektif. Sistem yang dihasilkan ini juga akan memberikan kemudahan kepada bendahara pengeluaran dalam melaksanakan penatausahaan dan pelaporan dan aplikasi tersebut dapat menginformasikan tentang pertanggungjawaban bendahara pengeluaran. Dalam pembuatan skripsi diperlukan beberapa metode. Metode yang digunakan dalam skripsi ini meliputi metode wawancara (Interview), metode lapangan (Observasi) dan Penelitian Perpustakaan (Library Research). Sistem Penatausahan dan Pelaporan Bendahara Pengeluaran merupakan sistem yang diajukan untuk menangani kendala-kendala serta kelemahan-kelemahan yang muncul pada sistem yang lama yang masih bersifat manual dan mengatasi permasalahan yang muncul pada saat proses pengolahan data
Sistem Pendataan Kegiatan Organisasi Badan Eksekutif Mahasiswa di STMIK-AMIK Riau
Authors: - Karpen
Published: October 2022

Badan Eksekutif Mahasiswa (BEM) merupakanorganisasi mahasiswa yang terdapat di kampus,kegiatan yang dilakukan sebagai perwakilanorganisasi dari mahasiswa meliputi internal daneksternal kampus. Selama ini kegiatan yangdilaksanakan tidak terdata dengan baik, karena masihdilakukan dengan menggunakan aplikasi office sepertiexcel dan word, tidak menggunakan sistem yangterdatabase. Belum adanya sistem yang digunakanuntuk pendataan kegiatan organisasi BEM di STMIKAMIK Riau, menyebabkan sulit mendapatkandata/informasi persemester yang diperlukan, maka itudibutuhkan sistem yang memiliki database, sehinggaakan memudahkan untuk melakukan pendataannya.Adanya sistem ini akan memberikan kemudahan dalampendataan kegiatan yang dilakukan oleh BEM danprosesnya akan lebih cepat. Sistem pendataan kegiatanorganisasi BEM di kampus STMIK-AMIK Riau,dilakukan dengan cara menganalisa terhadap semuadata kegiatan yang sudah atau belum dilakukan setiapsemesternya, dilanjutkan dengan perancangan sistem,melakukan uji coba dan implementasi. Maka adanyasistem pendataan kegiatan BEM ini akan memberikanhasil pendataan yang lebih akurat dan cepat sertamemberikan data/informasi yang lebih lengkapmengenai kegiatan organisasi BEM di kampus STMIKAMIK Riau
Metode SLR untuk Mengidentifikasi Isu-Isu dalam Software Engineering
Authors: - Lusiana , Suryani Melva
Published: October 2022

Software Engineering (SE) merupakan disiplin ilmu yang berkaitan dengan semua aspek produksi software yang dimulai dari tahap awal spesifikasi sampai pada pemeliharaan sistem yang digunakan [1], oleh sebab itu SE memiliki peran penting terhadap perkembangan dunia teknologi informasi. Penelitian ini mengkaji isu dan pedekatan yang digunakan dalam SE empat tahun terakhir (2010-2013) yang belum teridentifikasi dengan baik, dengan menggunakan metode SLR. SLR merupakan cara untuk mengidentifikasi, mengevaluasi dan menafsirkan semua penelitian yang tersedia dengan pertanyaan penelitian tertentu, bidang topik, atau fenomena yang menarik [2] (Kitchenham 2007). Dengan metode SLR isu-isu yang berhubungan dalam software engineering akan diidentifikasi dengan menggunakan kata kunci â€œwhat the problemâ€ (apa masalah) dan â€œhow to solve the problemâ€ (bagaimana memecahkan masalah tersebut). Hasil penelitian dapat dijadikan panduan oleh mahasiswa dan pembaca lainnya untuk melakukan penelitian yang berhubungan dengan SE selain itu, penelitian ini juga dapat membantu pembaca untuk mencari topik yang dominan penelitian dalam bidang SE
Penerapan Metode Clustering K-Means dan Metode Six Sigma untuk Mengetahui Tingkat Minat Baca Mahasiswa (Studi Kasus : STMIK â€“ AMIK Riau)
Authors: Agustin Wirta
Published: October 2022

Mahasiswa merupakan orang yang belajar di perguruan tinggi, baik di universitas, institut atau akademi. Mahasiswa sebagai penerus generasi bangsa dan sumber daya manusia Indonesia sangat dibutuhkan ide dan pendapatnya untuk membangun dan melakukan perubahan pada negeri ini. Mahasiswa harus bisa berpartisipasi dan mengembangkan ilmunya ke masyarakat dan lingkungannya. Mahasiswa juga diharapkan sebagai pencetus ide sekaligus eksekutor dari idenya, yang kemudian akan berpengaruh pada perubahan budaya, keadaan, atau sistem. Kualitas mahasiswa ini sangat terkait dengan minat baca yang dimilikinya. Selama ini STMIK-AMIK Riau belum memiliki sebuah metode yang dapat digunakan untuk mengetahui tingkat minat baca mahasiswa, sehingga tidak dapat diketahui bagaimana tingkat minat baca mahasiswa. Penelitian ini akan menggabungkan dua metode yaitu metode Clustering K-Means yangÂ  digunakan untuk mengelompokkan data-data dan metode Six Sigma (6Ïƒ) yangÂ  digunakan untuk melakukan analisis data dari hasil pengelompokan data dengan metode Clustering K-Means, sehingga dapat mengetahui tingkat minat baca pada mahasiswa dan upaya yang harus dilakukan untuk meningkatkan prestasi mahasiswa dan pemanfaatan perpustakaan kampus lebih optimal
Strategi Keuangan Menggunakan Metode Monte Carlo ( Studi Kasus Yayasan Komputasi Riau )
Authors: - Hamdani
Published: October 2022

Sekolah Tinggi Manajemen Informatika dan Komputer (STMIK RIAU) dan Akademi Manajemen Informatika Komputer (AMIK RIAU) adalah Perguruan Tinggi Komputer pertama di Riau. Perguruan Tinggi ini di bina oleh Yayasan Komputasi Riau. Dalam menjalankan operasional dari pengaturan keuangan Yayasan Komputasi Riau (YKR)Â  belum menggunakan metode monte carlo. Simulasi monte carlo dikenal juga dengan istilah sampling simulation. Sampling simulation ini menggambarkan kemungkinan penggunaan data sampel yang sudah diketahui atau diperkirakan distribusinya. Simulasi monte carlo mengikut sertakan random dan sampling dengan distribusi probabilitas yang dapatÂ  diketahui dan ditentukan. Dalam keuangan, Monte Carlo metode yang digunakan untuk mensimulasikan berbagai sumber ketidak pastian yang mempengaruhi nilai instrumen, portofolio atau investasi tersebut, dan kemudian menghitung wakil nilai yang diberikan nilai-nilai yang mungkin dari input yang mendasari. Dengan ada simulasi Monte Carlo ini Yayasan Komputasi Riau dapat optimalkan antara pendapatan dan pengeluaran, sehingga tidak terjadi minus anggaran di setiap item yang telah direncanakanÂ  atau yang telahÂ  dianggarkan pada saat sebelumnya
Prediksi Tingkat Curah Hujan di Kota Pekanbaru menggunakan Logika Fuzzy Mamdani
Authors: Julisman Zukri , - Erlin
Published: October 2022

Curah hujan merupakan unsur iklim yang menarik untuk diteliti, karena tidak mempunyai pola yang sama di wilayah Indonesia khususnya Pekanbaru. Stasiun Meteorologi (Stamet) Pekanbaru menggunakan metode dinamik maupun statistik, belum mampu untuk memprediksi tingkat curah hujan dengan akurasi yang lebih baik di Pekanbaru. Salah satu metode yang dapat digunakan untuk mengatasi masalah ini adalah logika fuzzy mamdani. Logika fuzzy mamdani memiliki toleransi terhadap data yang tidak tepat. Implementasi untuk prediksi tingkat curah hujan ini menggunakan Matlab dengan memanfaatkan Fuzzy Logic Matlab Toolbox yang telah disediakan. Dalam memprediksi tingkat curah hujan ini menggunakan 4 (empat) variabel input yaitu suhu, tekanan, kecepatan angin dan kelembaban relatif, serta 1 (satu) variabel output yaitu curah hujan. Untuk prediksi tingkat curah hujan di bulan Mei 2014 menghasilkan prediksi curah hujan 135.4386 mm3 dengan tingkat curah hujan terkategorikan SEDANG
Aplikasi Doa Harian Islam Pada Sistem Operasi Android
Authors: Saputra Rio , - T. Sy. Eiva Fadtha
Published: October 2022

Sistem operasi android adalah sebuah sistem operasi untuk perangkat mobile (smartphone dan tablet) berbasis linux yang mencakup sistem operasi, middleware dan aplikasi. Android menyediakan platform terbuka bagi para pengembang untuk menciptakan aplikasi mereka. Smartphone merupakan alat komunikasi yang mempunyai kemampuan multimedia dan komputing yang lebih dari pada handphone pada umumnya, seperti aplikasi yang dapat menampilkan doa-doa Islam. Doa Islam merupakan bacaan-bacaan yang berbentuk bahasa arab yang diambil berdasarkan Al-qurâ€™an dan Hadist. Sekarang ini sangat sedikit media-media telekomunikasi yang menyediakan aplikasi doa-doa Islam sedangkan kebutuhan user akan doa-doa Islam tersebut semakin bertambah. Dengan demikian perlu adanya aplikasi smartphone yang dapat menampilkan bacaan-bacaan serta suara dari doa-doa Islam tersebut. Hal ini yang melatarbelakangi penulis untuk mengangkat topik tersebut menjadi sebuah penelitian yang diberi nama Aplikasi Doa Harian Islam Pada Sistem Operasi Android, yaitu aplikasi yang dapat menampilkan bacaan-bacaan serta suara dari setiap doa-doa harian Islam yang dapat membantu user dalam kehidupan sehari-hari. Metode yang digunakan pada perancangan aplikasi ini adalah Unified Modelling Languange (UML) dengan menggunakan Use Case Diagram dan Activity Diagram. Bahasa pemograman yang digunakan pada perancangan aplikasi adalah bahasa pemograman java serta eclipse sebagai software yang digunakan untuk merancang dan mengembangkan aplikasi android
Sistem Informasi Administrasi Kemahasiswaan pada STMIK-AMIK Riau
Authors: - Rahmiati , - Torkis Nasution
Published: October 2022

Dalam Penyelenggaraan Perguruan Tinggi, porsi layanan terhadap mahasiswa sangat dominan dan menentukan. Wujud formal hubungan antara mahasiswa dan perguruan tinggi terlihat dalam layan administrasi kemahasiswaan. STMIK-AMIK Riau yang menaungi dua program studi, layanan administrasi kemahasiswaan sampai saat ini barulah pada sistem keuangan dan nilai mahasiswa yang berjalan secara optimal. Sementara itu layan administrasi surat menyurat mahasiswa belum ada aplikasi khusus yang digunakan. Permasalahan yang diutarakan diperlukan usaha untuk mengatasinya melalui pendekatan penerapan teknologi informasi. Untuk meningkatkan layanan yang baik terhadap mahasiswa, diperlukan suatu sistem yang berbasis komputer untuk mengatasi hal tersebut, informasi pengolah data proses pembuatan surat menyurat yang tertata dengan baikÂ  Tahapan penelitian dimulai dengan tahap analisa, perancangan sistem, konstruksi aplikasi dan implementasi sistem. Sistem yang dibuat dapat membantu BAAK dalam meningkatkan pelayanan administrasi surat menyurat yang lebih baik dan lebih cepat, sehingga mahasiswa dapat menerima pelayanan yang lebih baik
Aplikasi Keuangan Desa dalam Perencanaan Anggaran Kegiatan
Authors: Son Dilson -
Published: October 2022

UU Nomor 6 Tahun 2014 tentang desa yang salah satunya adalah desa diberikan kesempatan untuk mengelola keuangannya yang meliputi perencanaan, pelaksanaan, penatausahaan, pelaporan dan pertanggunghawaban. Tujuan penelitian adalah untuk merancang aplikasi Perencanaan Keuangan Desa (Alokasi Dana Desa) pada Kantor Wali Nagari Durian Tinggi. Metode penelitian mengunakan metode pengembangan sistem Design Science Research Method (DSRM) yang terdiri dari 6 (enam) tahapan mencakup tahap Identifikasi Masalah dan Motivasi, Mendefenisikan Obyek dari Solusi Permasalahan, Design dan Pengembangan, Demonstrasi (implementasi), Evaluasi dan Komunikasi. Analisa dan perancangan aplikasi divisualisasikan menggunakan Unified Modeling Language (UML). Perancangan interface aplikasi berbasis .Net Framework 4.5, perancangan database menggunakan MySQL, dan untuk pembuatan laporan menggunakan SAP Crystal Report. Hasil penelitian dapat mempermudah Pelaksana Teknik Pengelola Keuangan Desa (PTKD) dalam membuat Rencana Kerja Pemerintahan (RKP) Desa dan Rencana Anggaran Pendapatan dan Belanja Nagari (RAPB Desa). Penelitian selanjutnya disarankan untuk dapat mengembangkan aplikasi perencanaan keuangan desa khususnya pada perubahan RKA Pendapatan, Belanja, dan Pembiayaan baik berbasis desktip, web maupun aplikasi mobile.
Analisis dan Perancangan Sistem Informasi Pembelian dan Penjualan Mesin Fotokopi Pada CV. Jaya Mitra Abadi Dengan Metode PIECES
Authors: - Zulhendri , - Karpen
Published: October 2022

CV. Jaya Mitra Abadi adalah perusahaan yang bergerak di bidang penjualan mesin fotokopi dan importir resmi mesin fotokopi. Kendala Â yang dihadapi selama ini adalah pengolahan data yang masih dilakukan secara manual. Penanganan transaksi pembelian dan penjualan dilakukan dengan mencatat data transaksi pada sebuah buku besar dan pemanfaatan komputer masih sebatas penggunaan aplikasi Microsoft Office. Berdasarkan hal tersebut maka penelitian ini dilakukan dengan tujuan untuk menganalisa dan merancang suatu sistem informasi pembelian dan penjualan yang dapat menunjang kinerja dalam pengolahan data, penyajian informasi, serta mengurangi kendala-kendala yang muncul pada kegiatan pembelian dan penjualan mesin fotokopi. Metode yang digunakan dalam menganalisa sistem adalah metode PIECES (Performance, Information, Economy, Control, Efficiency, Service). Dengan metode ini, sistem dianalisa dari segi kinerja (performance), informasi (information), ekonomis (economy), pengendalian (control), efisiensi (efficiency) dan pelayanan (service). Sistem yang dihasilkan diharapkan dapat membantu penyajian berbagai laporan dengan cepat karena memiliki penyimpanan data yang terintegrasi (sudah adanya database yang dibuat khusus) sehingga dapat menambah, menghapus, mengedit serta mengambil data yang diperlukan.
TIPOLOGI SINTAKSIS BAHASA SABU
Authors: Kale Maneie Bangngu
Published: October 2022

Penelitian ini adalah penelitaian deskriptiv yang dilakakn dengan maksud untuk mencari tahu tata urutan kata dalam klausa verbal Bahasa Sabu. Teory yang digunakan adalah Peneliti menggunakan dua teori dalam penelitian ini yakni teori Lexical-Functional Grammar (LFG) atau dalam bahasa Indonesia dikenal dengan Tata Bahasa Leksikal-Fungsional (TLF) sebagai teori formal dan teori tipologi. Pada Bahasa Sabu (BS) ditemukan struktur dasar klausa intransitif yakni klausa yang hanya memiliki satu argumen inti yaitu SUBJ dengan pola tata urut kata VS dengan alternasi struktur yaitu SV; klausa verbal monotransitif yakni klausa dengan predikat verba yang dapat mengikat dua argumen inti, yang secara sintaktis dapat mengisi fungsi gramatikal SUBJ dan OBJ dengan pola VSO, dengan kecendrungan alternasi struktur SVO;  dan klausa verbal dwitransitif yaitu klausa yang verbanya menuntut dua argumen inti yang secara sintaksis berfungsi sebagai SUBJ, OBJ1, dan OBJ2. Klausa dwitransitif adalah klausa yang meminta kehadiran tiga argumen inti.
GENOMIC LIBRARIES
Authors: Kumar P Akhil , Meenakshi Y , Sakunthala R ,   DNR College
Published: October 2022

The genome of a creature might contain from a few million to a few hundred billion base sets of DNA, which might incorporate huge number of qualities. To study genomic components to exhaustively, the DNA is regularly broken into more modest, more reasonable by pieces. By and large known as a genomic "library ", the cloned sections can be separated and utilized for an assortment of uses, For Example, DNA sequencing, creation of proteins, investigation Of the protein communications, pathway designing, and looking for related qualities in different life forms. The best strategies to section the genome and build the library rely on the specific investigation to be performed. Albeit a few conventional employments of libraries have been to a great extent supplanted by the "future" strategies, old style development and examination of the genomic libraries stays a backbone of sub-atomic Science.
Extended mind-wandering
Authors: Bruineberg Jelle , Fabry Regina
Published: October 2022

Smartphone use plays an increasingly important role in our daily lives. Philosophical research that has used first wave or second wave theories of extended cognition in order to understand our engagement with digital technologies has focused on the contribution of these technologies to the completion of specific cognitive tasks (e.g., remembering, reasoning, problem-solving, navigation). However, in a considerable number of cases, everyday smartphone use is task-unrelated. In psychological research, these cases have been captured by notions such as absent-minded smartphone use (Marty-Dugas et al., 2018) or smartphone-related inattentiveness (Liebherr et al., 2020). Given the prevalence of these cases, we develop a conceptual framework that can accommodate the functional and phenomenological characteristics of task-unrelated smartphone use. To this end, we will integrate research on second wave extended cognition with mind-wandering research and introduce the concept of ‘extended mind-wandering’. Elaborating the family resemblances approach to mind-wandering (Seli, Kane, Smallwood, et al., 2018), we will argue that task-unrelated smartphone use shares many characteristics with mind-wandering. We will suggest that an empirically informed conceptual analysis of cases of extended mind-wandering can enrich current work on digitally extended cognition by specifying the influence of the attention economy on our cognitive dynamics.
Notch signaling and fluid shear stress in regulating osteogenic differentiation
Authors: Zhao Yuwen , Richardson Kiarra , Yang Rui , Bousraou Zoe , Lee Yoo Kyoung , Fasciano Samantha , Wang Shue
Published: October 2022

Osteoporosis is a common bone and metabolic disease that is characterized by bone density loss and microstructural degeneration. Human bone marrow-derived mesenchymal stem cells (hMSCs) are multipotent progenitor cells with the potential to differentiate into various cell types, including osteoblasts, chondrocytes, and adipocytes, which have been utilized extensively in the field of bone tissue engineering and cell-based therapy. Although fluid shear stress plays an important role in bone osteogenic differentiation, the cellular and molecular mechanisms underlying this effect remain poorly understood. Here, a locked nucleic acid (LNA)/DNA nanobiosensor was exploited to monitor mRNA gene expression of hMSCs that were exposed to physiologically relevant fluid shear stress to examine the regulatory role of Notch signaling during osteogenic differentiation. First, the effects of fluid shear stress on cell viability, proliferation, morphology, and osteogenic differentiation were investigated and compared. Our results showed shear stress modulates hMSCs morphology and osteogenic differentiation depending on the applied shear and duration. By incorporating this LNA/DNA nanobiosensor and alkaline phosphatase (ALP) staining, we further investigated the role of Notch signaling in regulating osteogenic differentiation. Pharmacological treatment is applied to disrupt Notch signaling to investigate the mechanisms that govern shear stress induced osteogenic differentiation. Our experimental results provide convincing evidence supporting that physiologically relevant shear stress regulates osteogenic differentiation through Notch signaling. Inhibition of Notch signaling mediates the effects of shear stress on osteogenic differentiation, with reduced ALP enzyme activity and decreased Dll4 mRNA expression. In conclusion, our results will add new information concerning osteogenic differentiation of hMSCs under shear stress and the regulatory role of Notch signaling. Further studies may elucidate the mechanisms underlying the mechanosensitive role of Notch signaling in stem cell differentiation.
Biomimetic nanomaterial-facilitated oxygen generation strategies for enhancing tumour treatment outcomes
Authors: Yang Zhongwen , Shi Changsong , Cheng Dongliang , Wang Yu , Xing Yan , Du Fanfan , Wu Fangfang , Jin Yao , Dong Yueli , Li Mengli
Published: October 2022

Hypoxia, as a typical hallmark of the tumour microenvironment (TME), has been verified to exist in most malignancies and greatly hinders the outcome of tumour treatments, including chemotherapy, photodynamic therapy, radiotherapy, and immunotherapy. Various approaches to alleviate tumour hypoxia have been reported. Among them, biomimetic nanomaterial-facilitated tumour oxygenation strategies, based on the engagement of human endogenous proteins, red blood cells, the cell membrane, and catalase, are the most impressive due to their excellent tumour active-targeting ability and superior tumour-selective capability, which, however, have not yet been systematically reviewed. Herein, we are ready to describe the current progress in biomimetic nanomaterial-facilitated tumour oxygenation strategies and corresponding improvements in tumour treatment outputs. In this review, the underlying mechanism behind the superior effect of these biomimetic nanomaterials, compared with other materials, on alleviating the hypoxic TME is highlighted. Additionally, the ongoing problems and potential solutions are also discussed.
Practical methods to identify seepage paths in dam abutments in semi-arid areas: The Mujib dam in Jordan
Authors: Al-Sheriadeh Mohanned S. , Amayreh Lubna K.
Published: October 2022

The Mujib Dam in Jordan experienced high seepage in 2004 in the right abutment. Initial examination of the cause blamed the rocks there and excluded the clay core hydro-fracturing. The problem later was resolved by grouting the right abutment heavily. This work believes that the grouting quantity was excessive and can be minimized if seepage paths were identified. For this purpose, the excavation cut photos were revisited during construction, the piezometric levels of wells drilled after the seepage event were examined, and the physio-chemical characteristics of seepage water were correlated to those in the reservoir. All those methods combined succeeded in finding the seepage paths and their percentage contribution to the total seepage volume. They found that three-fourths of the seepage water occurred through a small area circling the right abutment gallery stair shaft walls and suggested that the remaining one-fourth can be stopped over time by sediment deposition on the reservoir floor. Therefore, the previously applied grouting volume was high. In conclusion, the methods used in this work can identify the probable seepage paths and confine solutions to them.
Recent progress in the design, synthesis and applications of chiral metal-organic frameworks
Authors: Altaf Amna , Hassan Sadia , Pejcic Bobby , Baig Nadeem , Hussain Zakir , Sohail Manzar
Published: October 2022

Chiral Metal-Organic Frameworks (CMOFs) are unique crystalline and porous class of materials which is composed of organic linkers and metal ions. CMOFs surpass traditional organic and inorganic porous materials because of their tunable shape, size, functional diversity, and selectivity. Specific applications of CMOFs may be exploited by introducing desired functional groups. CMOFs have chiral recognition abilities, making them unique for chiral compound synthesis and separation. The CMOFs can be synthesized through different approaches. Two main approaches have been discussed, i.e., direct and indirect synthesis. Synthetic strategies play an essential role in getting desired properties in MOFs. CMOFs find potential applications in adsorption, asymmetric catalysis, luminescence, degradation, and enantioselective separation. The MOFs’ porosity, stability, and reusability make them an attractive material for these applications. The plethora of applications of CMOFs have motivated chemists to synthesize novel MOFs and number of MOFs have been ever-escalating. Herein, the synthetic methods of CMOFs and their various applications have been discussed.
Underexplored bacteria as reservoirs of novel antimicrobial lipopeptides
Authors: Clements-Decker Tanya , Kode Megan , Khan Sehaam , Khan Wesaal
Published: October 2022

Natural products derived from microorganisms play a prominent role in drug discovery as potential anti-infective agents. Over the past few decades, lipopeptides produced by particularly Bacillus, Pseudomonas, Streptomyces, Paenibacillus, and cyanobacteria species, have been extensively studied for their antimicrobial potential. Subsequently, daptomycin and polymyxin B were approved by the Food and Drug Administration as lipopeptide antibiotics. Recent studies have however, indicated that Serratia, Brevibacillus, and Burkholderia, as well as predatory bacteria such as Myxococcus, Lysobacter, and Cystobacter, hold promise as relatively underexplored sources of novel classes of lipopeptides. This review will thus highlight the structures and the newly discovered scaffolds of lipopeptide families produced by these bacterial genera, with potential antimicrobial activities. Additionally, insight into the mode of action and biosynthesis of these lipopeptides will be provided and the application of a genome mining approach, to ascertain the biosynthetic gene cluster potential of these bacterial genera (genomes available on the National Center for Biotechnology Information) for their future pharmaceutical exploitation, will be discussed.
The impact of coronary microvascular dysfunction on the discordance between fractional flow reserve and resting full-cycle ratio in patients with chronic coronary syndromes
Authors: Legutko Jacek , Niewiara Lukasz , Guzik Bartlomiej , Szolc Piotr , Podolec Jakub , Nosal Marcin , Diachyshyn Marta , Zmudka Krzysztof , Kleczynski Paweł
Published: October 2022

Background

Resting full-cycle ratio (RFR) is an alternative to fractional flow reserve (FFR) for the evaluation of borderline coronary artery lesions. Although FFR and RFR results are discordant in some cases, factors associated with the discordance remain unclear. The role of coronary microvascular dysfunction (CMD) is discussed as a potential mechanism to explain these discrepancies.

Aim

The study aimed to assess concordance between RFR and FFR in a real-life cohort from a high-volume center regarding the role of CMD.

Methods

Consecutive patients with borderline coronary lesions undergoing coronary functional testing for chronic coronary syndromes were included in the study. Measurements of RFR and FFR were performed alongside additional coronary flow reserve (CFR), resistance reserve ratio (RRR), and an index of microcirculatory resistance (IMR) measurements. CMD was defined according to the current guideline by either IMR ≥25 or CFR ≤2.0 in vessels with no significant stenosis.

Results

Measurements were performed in 157 coronary arteries, in 101 patients, with a median age of 66 y., 74% male, with prior history of arterial hypertension (96%), dyslipidaemia (91%), and diabetes (40%). The median value of vessel diameter stenosis was 45% according to QCA.

Overall, FFR and RFR values were significantly correlated (r = 0.66, p < 0.001), where positive FFR/negative RFR and negative FFR/positive RFR were observed in 6 (3.8%) and 38 (24.2%) of 157 vessels. The RFR/FFR discrepancy was present in 44 (28%) of measurements. CMD was confirmed in 28 (64%) of vessels with discrepant RFR/FFR and in 46 (41%) of vessels with concordant results (p = 0.01). In discordant RFR/FFR vessels, as compared to concordant ones, significantly lower values of CFR [median 1.95 (IQR: 1.37, 2.30) vs. 2.10 (IQR: 1.50, 3.00), p = 0.030] and RRR [median 2.50 (IQR: 1.60, 3.10) vs. 2.90 IQR (1.90, 3.90), p = 0.048] were observed.

Main predictors of RFR/FFR discrepancy in a univariate regression analysis were: higher age of patients [OR = 1.06 (1.01; 1.10), p = 0.010], presence of CMD [OR = 2.51 (1.23; 5.25), p = 0.012], lower CFR [OR = 1.64 (1.12; 2.56), p = 0.018], and lower RRR values [OR = 1.35 (95% CI: 1.03; 1.83), p = 0.038].

Conclusion

In discrepant RFR/FFR vessels, CMD is more prevalent than in concordant RFR/FFR measurements, which can be driven by lower CFR or RRR values. Further research is needed to confirm this observation.
A meta-analysis evaluating indirectly GLP-1 receptor agonists and arrhythmias in patients with type 2 diabetes and myocardial infarction
Authors: Liu Zhijie , Bian Ning , Wu Shaorong , Fan Yiming , Li Hairui , Yu Jian , Guo Jun , Chen Dongdong
Published: October 2022

Aims

At present, the effects of Glucagon-Like Peptide 1 Receptor agonists (GLP-1RAs) on arrhythmia in patients with type 2 diabetes mellitus (T2DM) and myocardial infarction (MI) are still unclear. Hence, this systematic review and meta-analysis aimed to investigate this association.

Methods and results

PubMed, Embase, Cochrane Library, and Web of Science were searched from inception to 30 April 2022. Randomized controlled trials (RCTs) that compared GLP-1RAs with placebo and met the critical criterion of a proportion of patients with T2DM and MI > 30% were included to verify our purpose indirectly. The outcomes of interest included atrial arrhythmias, ventricular arrhythmias, atrioventricular block (AVB), sinus arrhythmia, and cardiac arrest. Relative risk (RR) and 95% confidence intervals (CI) were pooled using a random-effects model. We included five RCTs with altogether 31,314 patients. In these trials, the highest proportion of patients with T2DM and MI was 82.6%, while the lowest was 30.7%. Compared to placebo, GLP-1RAs were associated with a lower risk of atrial arrhythmias (RR 0.81, 95% CI 0.70–0.95). There was no significant difference in the risk of ventricular arrhythmias (RR 1.26, 95% CI 0.87–1.80), AVB (RR 0.95, 95% CI 0.63–1.42), sinus arrhythmia (RR 0.62, 95% CI 0.26–1.49), and cardiac arrest (RR 0.97, 95% CI 0.52–1.83) between groups.

Conclusion

GLP-1RAs may be associated with reduced risk for atrial arrhythmias, which seems more significant for patients with T2DM combined with MI. More studies are needed to clarify the definitive anti-arrhythmic role of this drug.
Depressive disorders in older Chinese adults with essential hypertension: A classification tree analysis
Authors: Ruan Juan , Xu Yan-Min , Zhong Bao-Liang
Published: October 2022

Background

Although there has been accumulating evidence on the elevated risk of depression in hypertensive patients, data regarding depressive disorders in older adults with hypertension and the interplay between factors associated with depression in this population are very limited. Disentangling the mutual influences between factors may help illuminate the pathways involved in the pathogenesis of the comorbidity of depression in hypertension. This study investigated the prevalence of depressive disorders in older Chinese adults with hypertension and examined major correlates of depressive disorders and the interactions between correlates by using classification tree analysis (CTA).

Methods

In total, 374 older adults with essential hypertension were enrolled from seven urban and six rural primary care centers in Wuhan, China, and interviewed with the Chinese Mini-international Neuropsychiatric Interview 5.0. Family relationship and feelings of loneliness were assessed with standardized questions. A checklist was used to assess the presence of six major medical conditions: diabetes mellitus, heart disease, cerebrovascular disease, chronic obstructive pulmonary disease, chronic gastric ulcer, and arthritis.

Results

The 1-month prevalence rate of depressive disorders was 25.7%. The CTA model identified four major correlates of depressive disorders: loneliness was the most salient, followed by arthritis, family relationship, and heart disease. There were statistically significant interactions between loneliness and arthritis, loneliness and family relationship, and arthritis and heart disease.

Conclusion

Over one out of every four older Chinese adults with hypertension suffer from depressive disorders. Collaborative multidisciplinary management services are needed to reduce the burden of depression in hypertensive older adults, which may include social work outreach services to promote family relationship, mental health services to relive loneliness, and primary care services to manage arthritis and heart disease.
Myocarditis following COVID-19 vaccination in adolescents: Cardiac magnetic resonance imaging study
Authors: Shiyovich Arthur , Plakht Ygal , Witberg Guy , Rotstein Amichai , Aviv Yaron , Wiessman Maya , Kornowski Ran , Hamdan Ashraf
Published: October 2022

Introduction

Vaccination-associated myocarditis was reported following COVID-19 vaccine initially among persons aged 16 or older and recently among adolescents aged 12–15.

Objectives

To describe the clinical and cardiac magnetic resonance (CMR) characteristics of adolescents aged 12–15 with myocarditis following the administration of the BNT162b2 mRNA COVID-19 vaccine.

Methods

CMR of adolescents (age 12–15) with a clinical diagnosis of myocarditis within 42 days following the first COVID-19 vaccine were analyzed.

Results

A total of 182,605 adolescent were vaccinated, out of which 9 were diagnosed with clinically adjudicated myocarditis while CMR was performed in 5/9 patients (56%). Median age was 15 years (range 13–15), 4/5 (80%) males. All the patients we previously healthy. The ECG upon presentation was abnormal in 3/5 (60%) of patients. All cases were classified as clinically mild and no patient required inotropes or mechanical circulatory support treatment. The median follow-up time, for the 5-included patients, was 206 (IQR 192–229, range 179–233) days. During the follow-up, no re-admissions, deaths, or any other cardiac events have occurred.

The median time between the diagnosis to the CMR was 104 days (range 27–149). The median left ventricular ejection fraction was within normal range 65% (range 62–69). Native T1 was available in four patients, the local T1 value was increased in three of them. T2 values were available in two patients and were all within normal range. The median late gadolinium enhancement (LGE) was 2% (range 0–6%) with inferolateral wall being the most common location (3/5). The patterns of the LGE were as following: (i) mid-wall in 3 patients; (ii) epicardial in 1-patient. LGE in the pericardium was present in 2/5 patients with pericardial effusion present in 4/5 patients with a median diameter of 4 mm (range 3–5 mm) at end-systole.

Conclusions

CMR findings and clinical course of adolescents with COVID-19 vaccination associated myocarditis, are similar to those of older patients, being relatively mild and potentially implying favorable outcomes.
Deformation structural style of the rioni foreland fold-and-thrust belt, western greater caucasus: Insight from the balanced cross-section
Authors: Alania Victor , Melikadze George , Pace Paolo , Fórizs István , Beridze Tamar , Enukidze Onise , Giorgadze Anzor , Razmadze Alexander
Published: October 2022

The Rioni foreland fold-and-thrust belt is part of the Greater Caucasus pro-wedge and is one of the most important examples of the collision-driven far-field deformation of the Arabia-Eurasia convergence zone. Here we show the deformation structural style of the Rioni foreland fold-and-thrust belt based on seismic reflection profiles and regional balanced cross-section. The main style of deformation within the Rioni foreland fold-and-thrust belt is represented by a set of fault-propagation folds, duplexes, and triangle zone. The regional balanced cross-section shows that fault-propagation folds above the upper detachment level can develop by piggyback and break-back thrust sequences. Formation of fault-bend fold duplex structures above the lower detachment is related to piggyback thrust sequences. A balanced section restoration of compressional structures across the Rioni foreland fold-and-thrust belt provides a minimum estimate of shortening of −40%, equivalent −42.78 km. The synclines within the Rioni foreland fold-and-thrust belt are filled by the Middle Miocene-Pleistocene shallow marine and continental syn-tectonic sediments, forming a series of typical thrust-top basins. Fault-propagation folds and duplex structures formed the main structure of the thrust-top basin. The evolution of the thrust-top basins was mainly controlled by the kinematics of thrust sequences. Using end-member modes of thrust sequences, the thrust-top basins are divided into: 1) Type I-piggyback basin, 2) Type II-break-back basin, and 3) Type III—formation of thrust-top basin characterized by bi-vergent geometry and related to combined, piggyback and piggyback back thrust sequences.
Swabian MOSES 2021: An interdisciplinary field campaign for investigating convective storms and their event chains
Authors: Kunz Michael , Abbas Syed S. , Bauckholt Matteo , Böhmländer Alexander , Feuerle Thomas , Gasch Philipp , Glaser Clarissa , Groß Jochen , Hajnsek Irena , Handwerker Jan , Hase Frank , Khordakova Dina , Knippertz Peter , Kohler Martin , Lange Diego , Latt Melissa , Laube Johannes , Martin Lioba , Mauder Matthias , Möhler Ottmar , Mohr Susanna , Reitter René W. , Rettenmeier Andreas , Rolf Christian , Saathoff Harald , Schrön Martin , Schütze Claudia , Spahr Stephanie , Späth Florian , Vogel Franziska , Völksch Ingo , Weber Ute , Wieser Andreas , Wilhelm Jannik , Zhang Hengheng , Dietrich Peter
Published: October 2022

The Neckar Valley and the Swabian Jura in southwest Germany comprise a hotspot for severe convective storms, causing tens of millions of euros in damage each year. Possible reasons for the high frequency of thunderstorms and the associated event chain across compartments were investigated in detail during the hydro-meteorological field campaign Swabian MOSES carried out between May and September 2021. Researchers from various disciplines established more than 25 temporary ground-based stations equipped with state-of-the-art in situ and remote sensing observation systems, such as lidars, dual-polarization X- and C-band Doppler weather radars, radiosondes including stratospheric balloons, an aerosol cloud chamber, masts to measure vertical fluxes, autosamplers for water probes in rivers, and networks of disdrometers, soil moisture, and hail sensors. These fixed-site observations were supplemented by mobile observation systems, such as a research aircraft with scanning Doppler lidar, a cosmic ray neutron sensing rover, and a storm chasing team launching swarmsondes in the vicinity of hailstorms. Seven Intensive Observation Periods (IOPs) were conducted on a total of 21 operating days. An exceptionally high number of convective events, including both unorganized and organized thunderstorms such as multicells or supercells, occurred during the study period. This paper gives an overview of the Swabian MOSES (Modular Observation Solutions for Earth Systems) field campaign, briefly describes the observation strategy, and presents observational highlights for two IOPs.