bluuebunny/crossref_metadata_2025 huggingface dataset:
Study on the Impacts of Capillary Number and Initial Water Saturation on the Residual Gas Distribution by NMR
Authors: Li Tao , Wang Ying , Li Min , Ji Jiahao , Chang Lin , Wang Zheming
Published: July 2019

The determination of microscopic residual gas distribution is beneficial for exploiting reservoirs to their maximum potential. In this work, both forced and spontaneous imbibition (waterflooding) experiments were performed on a high-pressure displacement experimental setup, which was integrated with nuclear magnetic resonance (NMR) to reveal the impacts of capillary number (Ca) and initial water saturation (Swi) on the residual gas distribution over four magnitudes of injection rates (Q = 0.001, 0.01, 0.1 and 1 mL/min), expressed as Ca (logCa = −8.68, −7.68, −6.68 and −5.68), and three different Swi (Swi = 0%, 39.34% and 62.98%). The NMR amplitude is dependent on pore volumes while the NMR transverse relaxation time (T2) spectrum reflects the characteristics of pore size distribution, which is determined based on a mercury injection (MI) experiment. Using this method, the residual gas distribution was quantified by comparing the T2 spectrum of the sample measured after imbibition with the sample fully saturated by brine before imbibition. The results showed that capillary trapping efficiency increased with increasing Swi, and above 90% of residual gas existed in pores larger than 1 μm in the spontaneous imbibition experiments. The residual gas was trapped in pores by different capillary trapping mechanisms under different Ca, leading to the difference of residual gas distribution. The flow channels were mainly composed of micropores (pore radius, r < 1 μm) and mesopores (r = 1–10 μm) at logCa = −8.68 and −7.68, while of mesopores and macropores (r > 10 μm) at logCa = −5.68. At both Swi= 0% and 39.34%, residual gas distribution in macropores significantly decreased while that in micropores slightly increased with logCa increasing to −6.68 and −5.68, respectively.
Plasma–Chemical Hybrid NOx Removal in Flue Gas from Semiconductor Manufacturing Industries Using a Blade-Dielectric Barrier-Type Plasma Reactor
Authors: Yamasaki Haruhiko , Koizumi Yuki , Kuroki Tomoyuki , Okubo Masaaki
Published: July 2019

NOx is emitted in the flue gas from semiconductor manufacturing plants as a byproduct of combustion for abatement of perfluorinated compounds. In order to treat NOx emission, a combined process consisting of a dry plasma process using nonthermal plasma and a wet chemical process using a wet scrubber is performed. For the dry plasma process, a dielectric barrier discharge plasma is applied using a blade-barrier electrode. Two oxidation methods, direct and indirect, are compared in terms of NO oxidation efficiency. For the wet chemical process, sodium sulfide (Na2S) is used as a reducing agent for the NO2. Experiments are conducted by varying the gas flow rate and input power to the plasma reactor, using NO diluted in air to a level of 300 ppm to simulate exhaust gas from semiconductor manufacturing. At flow rates of ≤5 L/min, the indirect oxidation method verified greater removal efficiency than the direct oxidation method, achieving a maximum NO conversion rate of 98% and a NOx removal rate of 83% at 29.4 kV and a flow rate of 3 L/min. These results demonstrate that the proposed combined process consisting of a dry plasma process and wet chemical process is promising for treating NOx emissions from the semiconductor manufacturing industry.
Life Cycle Cost of Building Energy Renovation Measures, Considering Future Energy Production Scenarios
Authors: Gustafsson Moa Swing , Myhren Jonn Are , Dotzauer Erik , Gustafsson Marcus
Published: July 2019

A common way of calculating the life cycle cost (LCC) of building renovation measures is to approach it from the building side, where the energy system is considered by calculating the savings in the form of less bought energy. In this study a wider perspective is introduced. The LCC for three different energy renovation measures, mechanical ventilation with heat recovery and two different heat pump systems, are compared to a reference case, a building connected to the district heating system. The energy system supplying the building is assumed to be 100% renewable, where eight different future scenarios are considered. The LCC is calculated as the total cost for the renovation measures and the energy systems. All renovation measures result in a lower district heating demand, at the expense of an increased electricity demand. All renovation measures also result in an increased LCC, compared to the reference building. When aiming for a transformation towards a 100% renewable system in the future, this study shows the importance of having a system perspective, and also taking possible future production scenarios into consideration when evaluating building renovation measures that are carried out today, but will last for several years, in which the energy production system, hopefully, will change.
A Method of Estimating Mutual Inductance and Load Resistance Using Harmonic Components in Wireless Power Transfer System
Authors: Yang Dongsheng , Won Sokhui , Tian Jiangwei , Cheng Zixin , Kim Jongho
Published: July 2019

In general, for the WPT (Wireless Power Transfer) system, as the mutual inductance and load resistance are calculated according to the measured data of both the transmitter and receiver, the wireless communication modules are needed to share data. A method for estimating mutual inductance and load resistance without wireless communication is proposed, based on the fundamental and third harmonic components. The circuit is decomposed with respect to the frequencies, by which the mathematic model is established. The fundamental and harmonic components of the output voltage and current of a high-frequency inverter are found by FFT (Fast Fourier Transform). The experimental WPT system with a SiC power MOSFET is designed, and the effectiveness of the proposed method is verified by the simulation and experiment results. Additional hardware and frequency scanning operation are not needed because of the use of the harmonic components.
Statistical Study on Space Charge effects and Stage Characteristics of Needle-Plate Corona Discharge under DC Voltage
Authors: Wang Disheng , Du Lin , Yao Chenguo
Published: July 2019

The air’s partial discharges (PD) under DC voltage are obviously affected by space charges. Discharge pulse parameters have statistical regularity, which can be applied to analyze the space charge effects and discharge characteristics during the discharge process. Paper studies air corona discharge under DC voltage with needle-plate model. Statistical rules of repetition rate (n), amplitude (V) and interval time (∆t) are extracted, and corresponding space charge effects and electric field distributions in PD process are analyzed. The discharge stages of corona discharge under DC voltage are divided. Furthermore, reflected space charge effects, electric field distributions and discharge characteristics of each stages are summarized to better explain the stage discharge mechanism. This research verifies that microcosmic process of PD under DC voltage can be described based on statistical method. It contributes to the microcosmic illustration of gas PD with space charges.
Sector Subdivision Based SVPWM Strategy of Neutral-Point-Clamped Three-Level Inverter for Current Ripple Reduction
Authors: Zhang Guozheng , Wei Bingxu , Gu Xin , Li Xinmin , Zhou Zhanqing , Chen Wei
Published: July 2019

This paper presents a sector subdivision based space vector pulse width modulation (SVPWM) strategy with reduced current ripple for a three-level inverter. Using the output current ripple theory, closed-form expressions of average current ripple vectors for both continuous and discontinuous switching sequences are derived. Based on the sector and triangle distributions of conventional SVPWM strategy, each triangle is further divided into three small-regions. Then the switching sequence with the lowest magnitude of the average current ripple vector is applied in every small-region, so that the advantages of continuous pulse width modulation (CPWM) and discontinuous pulse width modulation (DPWM) under different modulation index conditions are combined to reduce the current ripple in the whole modulation range. The output performance of the proposed strategy is compared with the conventional CPWM and DPWM strategy, and experimental results verify that the proposed strategy could reduce the current ripple of three-level inverters effectively.
Effect of Woodchips Biochar on Sensitivity to Temperature of Soil Greenhouse Gases Emissions
Authors: Criscuoli Irene , Ventura Maurizio , Sperotto Andrea , Panzacchi Pietro , Tonon Giustino
Published: July 2019

Research Highlights: Biochar is the carbonaceous product of pyrolysis or the gasification of biomass that is used as soil amendment to improve soil fertility and increase soil carbon stock. Biochar has been shown to increase, decrease, or have no effect on the emissions of greenhouse gases (GHG) from soil, depending on the specific soil and biochar characteristics. However, the temperature sensitivity of these gas emissions in biochar-amended soils is still poorly investigated. Background and Objectives: A pot experiment was set up to investigate the impact of woodchips biochar on the temperature sensitivity of the main GHG (CO2, CH4, and N2O) emissions from soil. Materials and Methods: Nine pots (14 L volume) were filled with soil mixed with biochar at two application rates (0.021 kg of biochar/kg of soil and 0.042 kg of biochar/kg of soil) or with soil alone as the control (three pots per treatment). Pots were incubated in a growth chamber and the emissions of CO2, CH4, and N2O were monitored for two weeks with a cavity ring-down gas analyzer connected to three closed dynamic chambers. The temperature in the chamber increased from 10 °C to 30 °C during the first week and decreased back to 10 °C during the second week, with a daily change of 5 °C. Soil water content was kept at 20% (w/w). Results: Biochar application did not significantly affect the temperature sensitivity of CO2 and N2O emissions. However, the sensitivity of CH4 uptake from soil significantly decreased by the application of biochar, reducing the CH4 soil consumption compared to the un-amended soil, especially at high soil temperatures. Basal CO2 respiration at 10 °C was significantly higher in the highest biochar application rate compared to the control soil. Conclusions: These results confirmed that the magnitude and direction of the influence of biochar on temperature sensitivity of GHG emissions depend on the specific GHG considered. The biochar tested in this study did not affect soil N2O emission and only marginally affected CO2 emission in a wide range of soil temperatures. However, it showed a negative impact on soil CH4 uptake, particularly at a high temperature, having important implications in a future warmer climate scenario and at higher application rates.
Optimal Boundary Control of Non-Isothermal Viscous Fluid Flow
Authors: Baranovskii Evgenii S. , Domnich Anastasia A. , Artemov Mikhail A.
Published: July 2019

We study an optimal control problem for the mathematical model that describes steady non-isothermal creeping flows of an incompressible fluid through a locally Lipschitz bounded domain. The control parameters are the pressure and the temperature on the in-flow and out-flow parts of the boundary of the flow domain. We propose the weak formulation of the problem and prove the existence of weak solutions that minimize a given cost functional. It is also shown that the marginal function of this control system is lower semi-continuous.
Variable Number Tandem Repeats in the Mitochondrial DNA of Lentinula edodes
Authors: Kim Sinil , Song Yelin , Ha Byeongsuk , Moon Yoon Jung , Kim Minseek , Ryu Hojin , Ro Hyeon-Su
Published: July 2019

Variable number tandem repeats (VNTRs) in mitochondrial DNA (mtDNA) of Lentinula edodes are of interest for their role in mtDNA variation and their application as genetic marker. Sequence analysis of three L. edodes mtDNAs revealed the presence of VNTRs of two categories. Type I VNTRs consist of two types of repeat units in a symmetric distribution, whereas Type II VNTRs contain tandemly arrayed repeats of 7- or 17-bp DNA sequences. The number of repeat units was variable depending on the mtDNA of different strains. Using the variations in VNTRs as a mitochondrial marker and the A mating type as a nuclear type marker, we demonstrated that one of the two nuclei in the donor dikaryon preferentially enters into the monokaryotic cytoplasm to establish a new dikaryon which still retains the mitochondria of the monokaryon in the individual mating. Interestingly, we found 6 VNTRs with newly added repeat units from the 22 mates, indicating that elongation of VNTRs occurs during replication of mtDNA. This, together with comparative analysis of the repeating pattern, enables us to propose a mechanistic model that explains the elongation of Type I VNTRs through reciprocal incorporation of basic repeat units, 5’-TCCCTTTAGGG-3’ and its complementary sequence (5’-CCCTAAAGGGA-3’).
Adjustment Disorder: Current Developments and Future Directions
Authors: O’Donnell Meaghan L. , Agathos James A. , Metcalf Olivia , Gibson Kari , Lau Winnie
Published: July 2019

Despite its high prevalence in clinical and consultant liaison psychiatry populations, adjustment disorder research has traditionally been hindered by its lack of clear diagnostic criteria. However, with the greater diagnostic clarity provided in the Diagnostic and Statistical Manual of Mental Disorders – fifth edition (DSM-5) and the International Statistical Classification of Diseases and Related Health Problems, 11th edition (ICD-11), adjustment disorder has been increasingly recognised as an area of research interest. This paper evaluates the commonalities and differences between the ICD-11 and DSM-5 concepts of adjustment disorder and reviews the current state of knowledge regarding its symptom profile, course, assessment, and treatment. In doing so, it identifies the gaps in our understanding of adjustment disorder and discusses future directions for research.
Contamination and Health Risk Assessment of Heavy Metals in the Soil of Major Cities in Mongolia
Authors: Chonokhuu Sonomdagva , Batbold Chultem , Chuluunpurev Byambatseren , Battsengel Enkhchimeg , Dorjsuren Batsuren , Byambaa Batdelger
Published: July 2019

Using the case of Ulaanbaatar, Erdenet, and Darkhan cities from Mongolia, the study aimed to assess the contamination level and health risk assessment of heavy metals (As, Cr, Pb, Ni, and Zn) in urban soil. A total of 78 samples was collected from a variety of functional areas. The geoaccumulation index (Igeo) and integrated pollution index (IPI) were used in pollution assessment, while the health risk was scored using a hazard quotient (HQ) and health index (HI) for non-carcinogenic heavy metals, as well as a lifetime average daily dose (LADD) for carcinogenic heavy metals. The results show that the concentration of heavy metals in the soil samples taken from Darkhan city, which presented “uncontaminated” values in terms of Igeo for all metals, was relatively lower than other cities within the contamination assessment. Furthermore, the Igeo value signified “uncontimated to heavily contaminated” soil in the Ulaanbaatar and Erdenet cities. Typically, as for the IPI that observed similar trends with Igeo, the mean IPI values in Ulaanbaatar, Erdenet, and Darkhan were 1.33 (moderate level of pollution), 1.83 (moderate level of pollution), and 0.94 (low level of pollution), respectively. In terms of the assessment of potential health risk, there was a particular or different level of ingestion, dermal contact, and inhalation exposure pathway for human health. Among these three different pathways, the ingestion was estimated by the main contributor for health risk. Each value of HQ and HI indicated that soil heavy metals of studied cities were at a safe level (<1) or had the absence of a significant health risk there. In addition, the potential health risk for children was greater than for adults, where heavy metal values of HI for children had a high value compared to adults. We estimated carcinogenic risks through the inhalation exposure, and as a result, there were no significant risks for human health in the studied cities from three elements (As, Cr, and Ni).
A New Algorithms of Stroke Generation Considering Geometric and Structural Properties of Road Network
Authors: Liu Yi , Li Wenjing
Published: July 2019

Strokes are considered an elementary unit of road networks and have been widely used in their analysis and application. However, most conventional stroke generation methods are based solely on a fixed angle threshold, which ignores road networks’ geometric and structural properties. To remedy this, this paper proposes an algorithm for generating strokes that takes into account these additional geometric and structural road network properties and that reduces the impact of stroke generation on road network quality. To this end, we introduce a model of feature-based information entropy and then utilize this model to calculate road networks’ information volume and both the elemental and neighborhood level. To make our experimental results more objective, we use the Douglas-Peucker algorithm to simplify the information change curve and to obtain the optimal angle threshold range for generating strokes for different road network structures. Finally, we apply this model to three different road networks, and the optimal threshold ranges are 54°–63° (Chicago), 61°–63° (Moscow), 45°–48° (Monaco). And taking Monaco as an example, this paper conducts stroke selection experiments. The results demonstrate that our proposed algorithm has better connectivity and wider coverage than those based on a common angle threshold (60°).
Repression of the Glucocorticoid Receptor Increases Hypoxic-Ischemic Brain Injury in the Male Neonatal Rat
Authors: Knox-Concepcion Katherine R. , Figueroa Johnny D. , Hartman Richard E. , Li Yong , Zhang Lubo
Published: July 2019

Hypoxic-ischemic encephalopathy (HIE) resulting from asphyxia is the most common cause of neonatal brain damage and results in significant neurological sequelae, including cerebral palsy. The current therapeutic interventions are extremely limited in improving neonatal outcomes. The present study tests the hypothesis that the suppression of endogenous glucocorticoid receptors (GRs) in the brain increases hypoxic-ischemic (HI) induced neonatal brain injury and worsens neurobehavioral outcomes through the promotion of increased inflammation. A mild HI treatment of P9 rat pups with ligation of the right common carotid artery followed by the treatment of 8% O2 for 60 min produced more significant brain injury with larger infarct size in female than male pups. Intracerebroventricular injection of GR siRNAs significantly reduced GR protein and mRNA abundance in the neonatal brain. Knockdown of endogenous brain GRs significantly increased brain infarct size after HI injury in male, but not female, rat pups. Moreover, GR repression resulted in a significant increase in inflammatory cytokines TNF-α and IL-10 at 6 h after HI injury in male pups. Male pups treated with GR siRNAs showed a significantly worsened reflex response and exhibited significant gait disturbances. The present study demonstrates that endogenous brain GRs play an important role in protecting the neonatal brain from HI induced injury in male pups, and suggests a potential role of glucocorticoids in sex differential treatment of HIE in the neonate.
Reactions in the Radiosensitizer Misonidazole Induced by Low-Energy (0–10 eV) Electrons
Authors: Meißner Rebecca , Feketeová Linda , Illenberger Eugen , Denifl Stephan
Published: July 2019

Misonidazole (MISO) was considered as radiosensitizer for the treatment of hypoxic tumors. A prerequisite for entering a hypoxic cell is reduction of the drug, which may occur in the early physical-chemical stage of radiation damage. Here we study electron attachment to MISO and find that it very effectively captures low energy electrons to form the non-decomposed molecular anion. This associative attachment (AA) process is exclusively operative within a very narrow resonance right at threshold (zero electron energy). In addition, a variety of negatively charged fragments are observed in the electron energy range 0–10 eV arising from dissociative electron attachment (DEA) processes. The observed DEA reactions include single bond cleavages (formation of NO2−), multiple bond cleavages (excision of CN−) as well as complex reactions associated with rearrangement in the transitory anion and formation of new molecules (loss of a neutral H2O unit). While any of these AA and DEA processes represent a reduction of the MISO molecule, the radicals formed in the course of the DEA reactions may play an important role in the action of MISO as radiosensitizer inside the hypoxic cell. The present results may thus reveal details of the molecular description of the action of MISO in hypoxic cells.
Dyslipidemia and Meibomian Gland Dysfunction: Utility of Lipidomics and Experimental Prospects with a Diet-Induced Obesity Mouse Model
Authors: Osae Eugene A. , Steven Philipp , Redfern Rachel , Hanlon Samuel , Smith C. Wayne , Rumbaut Rolando E. , Burns Alan R.
Published: July 2019

Meibomian gland dysfunction (MGD) is the leading cause of dry eye disease and loss of ocular surface homeostasis. Increasingly, several observational clinical studies suggest that dyslipidemia (elevated blood cholesterol, triglyceride or lipoprotein levels) can initiate the development of MGD. However, conclusive evidence is lacking, and an experimental approach using a suitable model is necessary to interrogate the relationship between dyslipidemia and MGD. This systematic review discusses current knowledge on the associations between dyslipidemia and MGD. We briefly introduce a diet-induced obesity model where mice develop dyslipidemia, which can serve as a potential tool for investigating the effects of dyslipidemia on the meibomian gland. Finally, the utility of lipidomics to examine the link between dyslipidemia and MGD is considered.
pH Dependent Reversible Formation of a Binuclear Ni2 Metal-Center within a Peptide Scaffold
Authors: Keegan Brenna C. , Ocampo Daniel , Shearer Jason
Published: July 2019

A disulfide-bridged peptide containing two Ni2+ binding sites based on the nickel superoxide dismutase protein, {Ni2(SODmds)} has been prepared. At physiological pH (7.4), it was found that the metal sites are mononuclear with a square planar NOS2 coordination environment with the two sulfur-based ligands derived from cysteinate residues, the nitrogen ligand derived from the amide backbone, and a water ligand. Furthermore, S K-edge X-ray absorption spectroscopy indicated that the two cysteinate sulfur atoms ligated to nickel are each protonated. Elevation of the pH to 9.6 results in the deprotonation of the cysteinate sulfur atoms, and yields a binuclear, cysteinate bridged Ni22+ center with each nickel contained in a distorted square planar geometry. At both pH = 7.4 and 9.6, the nickel sites are moderately air sensitive, yielding intractable oxidation products. However, at pH = 9.6, {Ni2(SODmds)} reacts with O2 at an ~3.5-fold faster rate than at pH = 7.4. Electronic structure calculations indicate that the reduced reactivity at pH = 7.4 is a result of a reduction in S(3p) character and deactivation of the nucleophilic frontier molecular orbitals upon cysteinate sulfur protonation.
The Good and Bad News about the New Liquidity Rules of Basel III in Islamic Banking of Malaysia
Authors: Zainudin Shazleena Mohamed , Abdul Rasid Siti Zaleha , Omar Rosmini , Hassan Rohail
Published: July 2019

How has Basel III (Bank for International Settlements), regarding the computation, measurement, and management of the liquidity coverage ratio (LCR), vitalized the Islamic banking sector in emerging economies? Vice versa, what is the Islamic banking sector’s capacity to respond in embracing Basel III? This study aims to review the current issues faced by a bank as it discusses the current regulatory guidelines and operational challenges in implementing the system. Based on the implementation of LCR preliminary secondary data of Malaysian banks between 2010 and 2016, this study finds that the readiness of LCR system implementation in the Islamic banking industry is currently low because LCR is still relatively new for all financial institutions and vendors. There is a huge gap between the present system infrastructure of the banks and the LCR model requirements as defined by BNM (Bank Negara Malaysia) under Basel III. Nevertheless, this finding opens new horizons of understanding and practically offers further investigations for the whole banking sector in Malaysia. Thus, policy makers, regulators, and industry players should utilize a unique framework for Islamic banks when strategizing liquidity risk management.
Behavior of Cross Arms Inserted in Concrete-Filled Circular GFRP Tubular Columns
Authors: Xie Fang , Chen Ju , Yu Qian-Qian , Dong Xinlong
Published: July 2019

Fiber-reinforced polymer (FRP) materials nowadays have attracted much attention in both retrofitting of aged infrastructure and developing of new structural systems attributed to the outstanding mechanical properties. Extensive studies have been performed on concrete-filled glass FRP (GFRP) tubes for the potential application in piling, poles, highways overhead sign structures and bridge components. The new hybrid member also provides an alternative solution for traditional transmission structures. However, the connection between concrete-filled GFRP tubes and cross arms has not been fully understood. In this paper, an experimental study and theoretical analysis were conducted on the behavior of cross arms inserted in concrete-filled circular GFRP tubular columns. Steel bars with a larger stiffness in comparison with GFRP tubes were selected here for the cross arm to simulate a more severe scenario. The structural responses of the system when the cross arms were subjected to concentrated loads were carefully recorded. Experimental results showed that the concrete-filled GFRP tubes could offer a sufficient restraint to the deformation of the cross arm. No visible cracks were found on the GFRP tube at the corner of the cross arm where the stress and strain concentrated. Theoretical solutions based on available theories and equations were adopted to predict the displacement of the cross arms and a good agreement was achieved between the prediction results and experimental findings.
Optoelectronic Properties of C60 and C70 Fullerene Derivatives: Designing and Evaluating Novel Candidates for Efficient P3HT Polymer Solar Cells
Authors: Roy Juganta K. , Kar Supratik , Leszczynski Jerzy
Published: July 2019

Ten novel fullerene-derivatives (FDs) of C60 and C70 had been designed as acceptor for polymer solar cell (PSC) by employing the quantitative structure-property relationship (QSPR) model, which was developed strategically with a reasonably big pool of experimental power conversion efficiency (PCE) data. The QSPR model was checked and validated with stringent parameter and reliability of predicted PCE values of all designed FDs. They were assessed by the applicability domain (AD) and process randomization test. The predicted PCE of FDs range from 7.96 to 23.01. The obtained encouraging results led us to the additional theoretical analysis of the energetics and UV-Vis spectra of isolated dyes employing Density functional theory (DFT) and Time-dependent-DFT (TD-DFT) calculations using PBE/6-31G(d,p) and CAM-B3LYP/6-311G(d,p) level calculations, respectively. The FD4 is the best C60-derivatives candidates for PSCs as it has the lowest exciton binding energy, up-shifted lowest unoccupied molecular orbital (LUMO) energy level to increase open-circuit voltage (VOC) and strong absorption in the UV region. In case of C70-derivatives, FD7 is potential candidate for future PSCs due to its strong absorption in UV-Vis region and lower exciton binding energy with higher VOC. Our optoelectronic results strongly support the developed QSPR model equation. Analyzing QSPR model and optoelectronic parameters, we concluded that the FD1, FD2, FD4, and FD10 are the most potential candidates for acceptor fragment of fullerene-based PSC. The outcomes of tactical molecular design followed by the investigation of optoelectronic features are suggested to be employed as a significant resource for the synthesis of FDs as an acceptor of PSCs.
Fractal Analysis of the Fracture Evolution of Freeze-Thaw Damage to Asphalt Concrete
Authors: Li Jun , Wang Fengchi , Yi Fu , Ma Jie , Lin Zhenhuan
Published: July 2019

AC (asphalt concrete)-13, as the main material used in pavement construction, has been applied widely in seasonal frozen areas. In order to understand the fracture mechanism in the freeze-thaw (F-T) damage process, the mesoscale structure of AC-13 is obtained by computed tomography (CT). The fractal dimension of cracks is used as a damage evaluation index. Most previous studies have only focused on the fractal dimensions of whole cracks, while ignoring the fractal tectonic process and the self-similarity degree of a single fracture. Therefore, in this study, the intrinsic mechanism of fractures and damage were investigated. In addition, the critical crack stress and fracture toughness models of a single fracture in a freeze-thaw damage process are established for AC-13. The results indicate that in terms of the critical crack stress and fracture toughness, with the increase of F-T times, there is an obvious decreasing trend. The fracture model can effectively describe the fracture toughness calculated by ABAQUS in the process of freeze-thaw cycles.
A High Temperature Drop-On-Demand Droplet Generator for Metallic Melts
Authors: Imani Moqadam Saeedeh , Mädler Lutz , Ellendt Nils
Published: July 2019

In this study we present the design and functionality of a pneumatic drop-on-demand droplet generator that produces metallic micro particles with a size range of 300 µm to 1350 µm at high temperatures of up to 1600 °C. Molten metal droplets were generated from an EN 1.3505 (AISI 52100) steel which solidified during a falling distance of 6.5 m. We analyzed the resulting particle size and morphology using static image analysis. Furthermore, the droplet formation mode was analyzed using high-speed recordings and the pressure oscillation was measured in the crucible. The system is meant to be reproducible in all aspects and therefore the in-situ measurements are set to control the droplet size and trajectory during the run. Additionally, the ex-situ measurements are done on the particles in order to characterize them in size and morphology aspects.
Quantitative Measurements of Codeine and Fentanyl on a Surface-Enhanced Raman-Active Pad
Authors: Shende Chetan , Farquharson Amelia , Brouillette Carl , Smith Wayne , Farquharson Stuart
Published: July 2019

The USA is in the midst of an opioid crisis that included over 60,000 overdose fatalities in 2017, mostly unintentional. This is due to excessive use of prescription opioids and the use of very strong synthetic opioids, such as fentanyl, mixed with illicit street drugs. The ability to rapidly determine if people or packages entering the country have or contain drugs could reduce their availability, and thereby decrease the use of illicit drugs. In an effort to address this problem, we have been investigating the ability of surface-enhanced Raman spectroscopy to detect trace amounts of opioids on clothing and packages. Here, we report the measurement of codeine and fentanyl at 100 ng/mL for 5 min on a pad impregnated with gold colloids, as well as a preliminary measurement of 500 pg of fentanyl on a glass surface using one of these pads. The calculated limit of detection for this measurement was 40 pg. This data strongly suggests that these pads, used with portable Raman analyzers, would be invaluable to airport security, drug raids, crime scenes, and forensic analysis.
Cannabidiol Treatment Might Promote Resilience to Cocaine and Methamphetamine Use Disorders: A Review of Possible Mechanisms
Authors: Calpe-López Claudia , García-Pardo M. Pilar , Aguilar Maria A.
Published: July 2019

Currently, there are no approved pharmacotherapies for addiction to cocaine and other psychostimulant drugs. Several studies have proposed that cannabidiol (CBD) could be a promising treatment for substance use disorders. In the present work, the authors describe the scarce preclinical and human research about the actions of CBD on the effects of stimulant drugs, mainly cocaine and methamphetamine (METH). Additionally, the possible mechanisms underlying the therapeutic potential of CBD on stimulant use disorders are reviewed. CBD has reversed toxicity and seizures induced by cocaine, behavioural sensitization induced by amphetamines, motivation to self-administer cocaine and METH, context- and stress-induced reinstatement of cocaine and priming-induced reinstatement of METH seeking behaviours. CBD also potentiated the extinction of cocaine- and amphetamine-induced conditioned place preference (CPP), impaired the reconsolidation of cocaine CPP and prevented priming-induced reinstatement of METH CPP. Observational studies suggest that CBD may reduce problems related with crack-cocaine addiction, such as withdrawal symptoms, craving, impulsivity and paranoia (Fischer et al., 2015). The potential mechanisms involved in the protective effects of CBD on addiction to psychostimulant drugs include the prevention of drug-induced neuroadaptations (neurotransmitter and intracellular signalling pathways changes), the erasure of aberrant drug-memories, the reversion of cognitive deficits induced by psychostimulant drugs and the alleviation of mental disorders comorbid with psychostimulant abuse. Further, preclinical studies and future clinical trials are necessary to fully evaluate the potential of CBD as an intervention for cocaine and methamphetamine addictive disorders.
Mussel-Inspired Catechol-Functionalized Hydrogels and Their Medical Applications
Authors: Quan Wei-Yan , Hu Zhang , Liu Hua-Zhong , Ouyang Qian-Qian , Zhang Dong-Ying , Li Si-Dong , Li Pu-Wang , Yang Zi-Ming
Published: July 2019

Mussel adhesive proteins (MAPs) have a unique ability to firmly adhere to different surfaces in aqueous environments via the special amino acid, 3,4-dihydroxyphenylalanine (DOPA). The catechol groups in DOPA are a key group for adhesive proteins, which is highly informative for the biomedical domain. By simulating MAPs, medical products can be developed for tissue adhesion, drug delivery, and wound healing. Hydrogel is a common formulation that is highly adaptable to numerous medical applications. Based on a discussion of the adhesion mechanism of MAPs, this paper reviews the formation and adhesion mechanism of catechol-functionalized hydrogels, types of hydrogels and main factors affecting adhesion, and medical applications of hydrogels, and future the development of catechol-functionalized hydrogels.
Great Enhancement of Carbon Energy Storage through Narrow Pores and Hydrogen-Containing Functional Groups for Aqueous Zn-Ion Hybrid Supercapacitor
Authors: Liu Chao , Wu Jian-Chun , Zhou Haitao , Liu Menghao , Zhang Dong , Li Shilin , Gao Hongquan , Yang Jianhong
Published: July 2019

The proton transfer mechanism on the carbon cathode surface has been considered as an effective way to boost the electrochemical performance of Zn-ion hybrid supercapacitors (SCs) with both ionic liquid and organic electrolytes. However, cheaper, potentially safer, and more environmental friendly supercapacitor can be achieved by using aqueous electrolyte. Herein, we introduce the proton transfer mechanism into a Zn-ion hybrid supercapacitor with the ZnSO4 aqueous electrolyte and functionalized activated carbon cathode materials (FACs). We reveal both experimentally and theoretically an enhanced performance by controlling the micropores structure and hydrogen-containing functional groups (–OH and –NH functions) of the activated carbon materials. The Zn-ion SCs with FACs exhibit a high capacitance of 435 F g−1 and good stability with 89% capacity retention over 10,000 cycles. Moreover, the proton transfer effect can be further enhanced by introducing extra hydrogen ions in the electrolyte with low pH value. The highest capacitance of 544 F g−1 is obtained at pH = 3. The proton transfer process tends to take place preferentially on the hydroxyl-groups based on the density functional theory (DFT) calculation. The results would help to develop carbon materials for cheaper and safer Zn-ion hybrid SCs with higher energy.
Mechanochemical Synthesis of CuO/MgAl2O4 and MgFe2O4 Spinels for Vanillin Production from Isoeugenol and Vanillyl Alcohol
Authors: Rahmanivahid Behgam , Pinilla-de Dios Maria , Haghighi Mohammad , Luque Rafael
Published: July 2019

CuO/MgAl2O4 and CuO/MgFe2O4 catalysts were successfully synthesized with the use of spinel supports by a very simple and low-cost mechanochemical method. High-speed ball-milling was used to synthesize these catalyst supports for the first time. Materials were subsequently characterized by using XRD, FESEM, TEM, EDS-Dot mapping, XPS, BET-BJH, and Magnetic Susceptibility to investigate the physical-chemical characteristics of the catalysts. Acidity evaluation results indicated that the catalyst with the Mg-Al spinel support had more acid sites. XRD results showed a successful synthesis of the catalysts with large crystal sizes. Both catalysts were used in isoeugenol oxidation and vanillyl alcohol to vanillin reactions, with the CuO/MgAl2O4 showing optimum results. This catalyst provided 67% conversion (74% selectivity) after 2 h and this value improved to 81% (selectivity 100%) with the second reaction after 8 h. The CuO/MgFe2O4 catalyst in the first reaction after five hours revealed 53% conversion (47% selectivity) and after eight hours with the second reaction, the conversion value improved to 64% (100% selectivity). In terms of reusability, CuO/MgAl2O4 showed better results than the CuO/MgFe2O4 catalyst, for both reactions.
Oil Extraction and Evaluation from Yellow Horn Using a Microwave-Assisted Aqueous Saline Process
Authors: Huang Yulong , Yin Zhenxiong , Guo Jie , Wang Fengxia , Zhang Ji
Published: July 2019

This study investigates an aqueous salt process (ASP) combined with microwave-assisted extraction (MAE) for the seed oil extraction from yellow horn (Xanthoceras sorbifolium Bunge). The NaCl concentration in the oil extraction process affected the oil extraction yield. Box–Behnken design (BBD) and response surface methodology (RSM) were used to optimize the extraction process. The optimal operating parameters were: 24 g/L NaCl, 300 W microwave power, 4:1 water to material ratio, an 80 min extraction time, and 45 °C extraction temperature. The chemical composition of the extracted seed oil was analyzed using gas chromatography–mass spectrometry (GC-MS). This extraction technique for yellow horn seed oil provided high throughput and high-quality oil. The present research offers a kind of green extraction method for edible oil in the food industry.
Nervisides I–J: Unconventional Side-Chain-Bearing Cycloartane Glycosides from Nervilia concolor
Authors: Tran Thi-Ngoc-Mai , Bernadat Guillaume , Mai Dinh-Tri , Nguyen Van-Kieu , Sichaem Jirapast , Nguyen Tan-Phat , Tran Cong-Luan , Do Phuong-Vy , Tran Nguyen-Minh-An , Nguyen Huu-Hung , Beniddir Mehdi A. , Duong Thuc-Huy , Le Pogam Pierre
Published: July 2019

Two new cycloartane glycosides, nervisides I–J, were isolated from Nervilia concolor whole plants. Their structures were unambiguously established by interpretation of their HRESIMS and 1D and 2D NMR data. These cycloartanes comprised a stereogenic center at C-24, the R configuration of which was assigned based on DFT-NMR calculations and the subsequent DP4 probability score. These compounds were tested for cytotoxicity against K562 and MCF-7 tumor cell lines, revealing mild cytotoxic activity.
Generation and Application of Fluorescent Anti-Human β2-Microglobulin VHHs via Amino Modification
Authors: Huang Chundong , Li Da , Ren Jun , Ji Fangling , Jia Lingyun
Published: July 2019

The functionalization of VHHs enables their application in almost every aspect of biomedical inquiry. Amino modification remains a common strategy for protein functionalization, though is considered to be inferior to site-specific methods and cause protein property changes. In this paper, four anti-β2M VHHs were selected and modified on the amino group by NHS-Fluo. The impacts of amino modification on these VHHs were drastically different, and among all th examples, the modified NB-1 maintained the original stability, bioactivity and homogeneity of unmodified NB-1. Specific recognition of VHHs targeting β2M detected by fluorescence imaging explored the possible applications of VHHs. Via this study, we successfully functionalized the anti-β2M VHHs through amino modification and the results are able to instruct the simple and fast functionalization of VHHs in biomedical researches.
Coinage-Metal Bond between [1.1.1]Propellane and M2/MCl/MCH3 (M = Cu, Ag, and Au): Cooperativity and Substituents
Authors: Wang Ruijing , Yang Shubin , Li Qingzhong
Published: July 2019

A coinage-metal bond has been predicted and characterized in the complexes of [1.1.1]propellane (P) and M2/MCl/MCH3 (M = Cu, Ag, and Au). The interaction energy varies between −16 and −47 kcal/mol, indicating that the bridgehead carbon atom of P has a good affinity for the coinage atom. The coinage-metal bond becomes stronger in the Ag < Cu < Au sequence. Relative to M2, both MCl and MCH3 engage in a stronger coinage-metal bond, both -Cl and -CH3 groups showing an electron-withdrawing property. The formation of coinage-metal bonding is mainly attributed to the donation orbital interactions from the occupied C-C orbital into the empty metal orbitals and a back-donation from the occupied d orbital of metal into the empty C-C anti-bonding orbital. In most complexes, the coinage-metal bond is dominated by electrostatic interaction, with moderate contribution of polarization. When P binds simultaneously with two coinage donors, negative cooperativity is found. Moreover, this cooperativity is prominent for the stronger coinage-metal bond.
A Quick and Efficient Non-Targeted Screening Test for Saffron Authentication: Application of Chemometrics to Gas-Chromatographic Data
Authors: Morozzi Pietro , Zappi Alessandro , Gottardi Fernando , Locatelli Marcello , Melucci Dora
Published: July 2019

Saffron is one of the most adulterated food products all over the world because of its high market prize. Therefore, a non-targeted approach based on the combination of headspace flash gas-chromatography with flame ionization detection (HS-GC-FID) and chemometrics was tested and evaluated to check adulteration of this spice with two of the principal plant-derived adulterants: turmeric (Curcuma longa L.) and marigold (Calendula officinalis L.). Chemometric models were carried out through both linear discriminant analysis (LDA) and partial least squares discriminant analysis (PLS-DA) from the gas-chromatographic data. These models were also validated by cross validation (CV) and external validation, which were performed by testing both models on pure spices and artificial mixtures capable of simulating adulterations of saffron with the two adulterants examined. These models gave back satisfactory results. Indeed, both models showed functional internal and external prediction ability. The achieved results point out that the method based on a combination of chemometrics with gas-chromatography may provide a rapid and low-cost screening method for the authentication of saffron.
Improving the Physical and Oxidative Stability of Emulsions Using Mixed Emulsifiers: Casein-Octenyl Succinic Anhydride Modified Starch Combinations
Authors: Yang Liu , Qin Xiaoli , Kan Jianquan , Liu Xiong , Zhong Jinfeng
Published: July 2019

This study aims to investigate the influence of casein and octenyl succinic anhydride modified starch (OSAS) combinations on the physical and oxidative stability of fish oil-in-water emulsions. The interaction between casein and OSAS was manifested in changes in protein structure and hydrogen-bonding interaction. Casein–OSAS combinations could effectively inhibit droplet aggregation at pH 4 and attenuate droplet growth at a high CaCl2 concentration of 0.2 mol/L, compared with casein as an emulsifier. Nanoemulsions stabilized by casein–OSAS combinations or casein showed better oxidative stability compared with OSAS-stabilized emulsions. Therefore, casein–OSAS combinations can improve some physical properties of protein-based emulsions and oxidative stability of modified starch-based emulsions, suggesting protein-modified starch combinations are more promising in the emulsion-based food industry compared to each of the two emulsifiers alone.
Selected Papers from the 1st International Online Conference on Nanomaterials
Authors: Díez-Pascual Ana María , Chen Guanying
Published: July 2019

After decades of intense research, nanomaterials are now an integral part of many applications and enjoy the attention of a large research community [...]
Preconception and Prenatal Nutrition and Neurodevelopmental Disorders: A Systematic Review and Meta-Analysis
Authors: Li Mengying , Francis Ellen , Hinkle Stefanie N. , Ajjarapu Aparna S. , Zhang Cuilin
Published: July 2019

Preconception and prenatal nutrition is critical for fetal brain development. However, its associations with offspring neurodevelopmental disorders are not well understood. This study aims to systematically review the associations of preconception and prenatal nutrition with offspring risk of neurodevelopmental disorders. We searched the PubMed and Embase for articles published through March 2019. Nutritional exposures included nutrient intake or status, food intake, or dietary patterns. Neurodevelopmental outcomes included autism spectrum disorders (ASD), attention deficit disorder-hyperactivity (ADHD) and intellectual disabilities. A total of 2169 articles were screened, and 20 articles on ASD and 17 on ADHD were eventually reviewed. We found an overall inverse association between maternal folic acid or multivitamin supplementation and children’s risk of ASD; a meta-analysis including six prospective cohort studies estimated an RR of ASD of 0.64 (95% CI: 0.46, 0.90). Data on associations of other dietary factors and ASD, ADHD and related outcomes were inconclusive and warrant future investigation. Future studies should integrate comprehensive and more objective methods to quantify the nutritional exposures and explore alternative study design such as Mendelian randomization to evaluate potential causal effects.
Initiated Babesia ovata Sexual Stages under In Vitro Conditions Were Recognized by Anti-CCp2 Antibodies, Showing Changes in the DNA Content by Imaging Flow Cytometry
Authors: Nguyen Thu-Thuy , Dang-Trinh Minh-Anh , Higuchi Luna , Mosqueda Juan , Hakimi Hassan , Asada Masahito , Yamagishi Junya , Umemiya-Shirafuji Rika , Kawazu Shin-ichiro
Published: July 2019

Sexual stage induction under in vitro conditions is useful for biological and molecular studies of Babesia parasites. Therefore, in the present study, we induced B. ovata tick stages using the chemical inducers: xanthurenic acid (XA), dithiothreitol (DTT) and tris (2-carboxyethyl) phosphine (TCEP) at 27 °C or 37 °C conditions. Cultures at low temperature (27 °C) or treated with XA/TCEP induced a large number of extra-erythrocytic merozoites, which transformed into round shape cells at 12–24 h post-induction (pi). However, typical forms of tick stages (aggregation forms and the spiky forms/ray bodies) were only observed in the cultures treated with 40 mM or 60 mM of DTT during 3–6 h pi. The induced cells were recognized by anti-CCp2 rabbit antisera. DNA content of the cell population treated with 40 mM of DTT was analyzed by imaging flow cytometry at 0, 12 and 48 h pi. The results indicated that the parasite population with diploid-like double DNA content increased at 48 h pi. Our observations on morphological and changes in the DNA content provide useful information for understanding the life cycle of B. ovata under in vitro conditions, which will facilitate further studies on basic biology and the development of transmission blocking vaccines against bovine babesiosis.