bluuebunny/crossref_metadata_2025 huggingface dataset:
Gastric cancer presenting with ramucirumab-related gastrocolic fistula successfully managed by colonic stenting: a case report
Authors: Fukuya Hiroki , Iboshi Yoichiro , Wada Masafumi , Sumida Yorinobu , Harada Naohiko , Nakamuta Makoto , Fujii Hiroyuki , Ihara Eikichi
Published: May 2023

We report a rare case of gastric cancer presenting with a gastrocolic fistula during ramucirumab and paclitaxel combination therapy that was successfully managed with colonic stenting. A 75-year-old man was admitted to our hospital with the chief complaint of melena. Esophagogastroduodenoscopy revealed a large ulcerated tumor in the lower stomach, judged by laparoscopy as unresectable (sT4bN1M0). After four cycles of first-line chemotherapy with S-1 plus oxaliplatin, the patient showed disease progression, and second-line therapy with ramucirumab and paclitaxel was started. At the end of the third cycle, the patient had gastric antral stenosis, which necessitated the placement of a gastroduodenal stent. When the patient complained of diarrhea 10 days later, esophagogastroduodenoscopy revealed a fistula between the greater curvature of the stomach and the transverse colon. The fistula was covered by double colonic stenting, with a covered metal stent placed within an uncovered metal stent, after which leakage from the stomach to the colon stopped.
A practical approach for small bowel bleeding
Authors: Kim Sung Eun , Kim Hyun Jin , Koh Myeongseok , Kim Min Cheol , Kim Joon Sung , Nam Ji Hyung , Cho Young Kwan , Choe A Reum ,   The Research Group for Capsule Endoscopy and Enteroscopy of the Korean Society of Gastrointestinal Endoscopy
Published: May 2023

Gastrointestinal (GI) bleeding is one of the most common conditions among patients visiting emergency departments in Korea. GI bleeding is divided into upper and lower GI bleeding, according to the bleeding site. GI bleeding is also divided into overt and occult GI bleeding based on bleeding characteristics. In addition, obscure GI bleeding refers to recurrent or persistent GI bleeding from a source that cannot be identified after esophagogastroduodenoscopy or colonoscopy. The small intestine is the largest part of the alimentary tract. It extends from the pylorus to the cecum. The small intestine is difficult to access owing to its long length. Moreover, it is not fixed to the abdominal cavity. When hemorrhage occurs in the small intestine, the source cannot be found in many cases because of the characteristics of the small intestine. In practice, small-intestinal bleeding accounts for most of the obscure GI bleeding. Therefore, in this review, we introduce and describe systemic approaches and examination methods, including video capsule endoscopy and balloon enteroscopy, that can be performed in patients with suspected small bowel bleeding in clinical practice.
Development of Malarial Enzyme Inhibitors
Authors:   , Līdumniece Elīna
Published: May 2023

The research presented in the Thesis describes the development of synthesis methods to obtain peptidic boronic acid SUB1 inhibitors. The established synthetic routes enabled an access of various peptidic boronic acids with modified P1, P3 and P5 positions. The newly synthesized inhibitors were evaluated for their ability to inhibit SUB1 as well as for their antimalarial potency in cell-based assays and in vitro selectivity counter screen tests. The research has resulted in a series of compounds with low nanomolar inhibitory potency in SUB1 enzymatic assays, several of which displayed sub-micromolar inhibitory potency in P. falciparum parasite growth tests.
VLADAVINA PRAVA I DISKRIMINACIJA LGBTI OSOBA U BOSNI I HERCEGOVINI
Authors: ŠKRBIĆ Ajla , MIKOVIĆ Borjana
Published: May 2023

Rad daje doprinos definisanju načela vladavine prava, čije je značenje još uvijek sporno i neusaglašeno, iako je u središtu ne samo procesa proširenja Evropske unije, nego i moderne demokratije uopšte. Autorke potom analiziraju stanje vladavine prava u Bosni i Hercegovini kroz istraživanje da li i u kojem omjeru u ovoj državi postoji diskriminacija prema LGBTI osobama. Sagledavanjem trenutnih izazova, ali i perspektive zaštite ljudskih prava ovih osoba u budućnosti - radom se identifikuju ozbiljni nedostaci u zaštiti LGBTI oso- ba od diskriminacije. Autorice ukazuju na mjere koje je potrebno poduzeti kako bi se vladavina prava u Bosni i Hercegovini unaprijedila i kako bi ova država postala dio modernog zapadnoevropskog pravnog okruženja i članica Evropske unije.
Problems of the Implementation of the Principle of Legality by Police Officers when Applying Measures to Ensure Proceedings in Cases of Administrative Offenses
Authors: Sidorov Eduard Tomovich
Published: May 2023

The object of the study is the social relations that arise when police officers apply measures to ensure proceedings in cases of administrative offenses. The subject of the study is the legal norms contained in Chapter 27 of the Code of Administrative Offenses of the Russian Federation. The proposed article analyzes a number of measures to ensure the proceedings in cases of administrative offenses used by police officers in the exercise of official powers. The purpose of the work is to conduct a study of the theoretical provisions and law enforcement practice of the internal affairs bodies on the application of measures to ensure proceedings in cases of administrative offenses and, based on this, formulate proposals and recommendations for improving police activities in this area. As a result of the conducted research, the following conclusions were formulated. 1. Measures to ensure the proceedings in cases of administrative offenses, which are applied by the internal affairs bodies in the implementation of administrative and jurisdictional activities, significantly restrict the rights and freedoms of citizens. 2. Police officers exercising their powers of authority may apply them only on the basis of the Code of Administrative Offences of the Russian Federation, which contains both administrative-legal and administrative-procedural norms. 3. Other laws and by-laws should not contain measures of administrative and procedural support that are not regulated by the Administrative Code of the Russian Federation. 4. The law enforcement practice of the internal affairs bodies in the field of bringing citizens to administrative responsibility shows the need to develop administrative procedures for the application of measures to ensure proceedings in cases of administrative offenses. 5. These administrative procedures (the procedure for conducting a personal search, the procedure for conducting a vehicle inspection, etc.) should be fixed in regulatory legal acts and regulate in detail the procedure for their conduct.
Online Testing ‐ Is Evaluation System Witnessing a Paradigm Shift?
Authors: Shubha L. N. , Noorain Afeefa
Published: May 2023

The Corona virus pandemic swept the globe, bringing widespread fear and uncertainty. Academicians were busy conducting and evaluating students on various online platforms while the global attention was on finding a cure and stopping transmission. A paradigm shift occurred in the evaluation
system. To assess students, the test method included digital technology. Various online assessing approaches used during the Covid -19 pandemic are presented in this research. The study’s goal is to determine the benefits and drawbacks of conducting online exams, as well as if tech-enabled
testing platforms are the way of the future.
The Perspectives of Indian University Students Regarding Disruptive Technologies: An Empirical Study
Authors: Manchanda Manisha , Jyotsna Arora
Published: May 2023

The rate of technological disruption is at an all-time high at present. The last two years are considered to be among the most destructive in the past fifty years. The entire world experienced difficulties as a result of the COVID-19 epidemic. The proliferation of viruses has had a
tremendous impact on people’s personal and professional lives. None of the business operations were unaffected. The definitions of companies have shifted. Business strategies have shifted paradigmatically. Every business sector must rethink their approach, including the education sector.
The education sector is one of the world’s largest and fastest-growing industries. Prior to COVID, the domain of online education was expanding at a moderate rate, whereas the online education system has expanded dramatically. Students and teachers had to deal with technology in ways
they had never dealt with before. Users and developers were both spending significantly more time with technology. This intensive exposure to technology has affected the lives of both students and educators in some way. Through this study, we seek to comprehend the viewpoints of students regarding
their exposure to disruptive technology. Since education in all subjects may be easily offered through technological models, students from several domains are identified for analysis. In this study, how students perceive disruptive technology is discussed. For this objective, a data collection
instrument in the form of an e-questionnaire is constructed and distributed to the selected respondents. The data was collected for 129 students at the top-ranked NIRF institutions. As needed, the data is evaluated using descriptive and inferential statistical approaches.
Dendritic growth and synaptic organization from activity-independent cues and local activity-dependent plasticity
Authors: Kirchner Jan H , Euler Lucas , Fritz Ingo , Ferreira Castro André , Gjorgjieva Julijana
Published: May 2023

Dendritic branching and synaptic organization shape single-neuron and network computations. How they emerge simultaneously during brain development as neurons become integrated into functional networks is still not mechanistically understood. Here, we propose a mechanistic model in which dendrite growth and the organization of synapses arise from the interaction of activity-independent cues from potential synaptic partners and local activity-dependent synaptic plasticity. Consistent with experiments, three phases of dendritic growth – overshoot, pruning, and stabilization – emerge naturally in the model. The model generates stellate-like dendritic morphologies that capture several morphological features of biological neurons under normal and perturbed learning rules, reflecting biological variability. Model-generated dendrites have approximately optimal wiring length consistent with experimental measurements. In addition to establishing dendritic morphologies, activity-dependent plasticity rules organize synapses into spatial clusters according to the correlated activity they experience. We demonstrate that a trade-off between activity-dependent and -independent factors influences dendritic growth and synaptic location throughout development, suggesting that early developmental variability can affect mature morphology and synaptic function. Therefore, a single mechanistic model can capture dendritic growth and account for the synaptic organization of correlated inputs during development. Our work suggests concrete mechanistic components underlying the emergence of dendritic morphologies and synaptic formation and removal in function and dysfunction, and provides experimentally testable predictions for the role of individual components.
The effect of FMT and vitamin C on immunity-related genes in antibiotic-induced dysbiosis in mice
Authors: Huang Xiaorong , Zhang Yv , Huang Junsong , Gao Wenli , Yongfang Xie , Zeng Chuisheng , Gao Chao
Published: May 2023

Antibiotics are double-edged swords. Although antibiotics are used to inhibit pathogenic bacteria, they also run the risk of destroying some of the healthy bacteria in our bodies. We examined the effect of penicillin on the organism through a microarray dataset, after which 12 genes related to immuno-inflammatory pathways were selected by reading the literature and validated using neomycin and ampicillin. The expression of genes was measured using qRT-PCR. Several genes were significantly overexpressed in antibiotic-treated mice, including CD74 and SAA2 in intestinal tissues that remained extremely expressed after natural recovery. Moreover, transplantation of fecal microbiota from healthy mice to antibiotic-treated mice was made, where GZMB, CD3G, H2-AA, PSMB9, CD74, and SAA1 were greatly expressed; however, SAA2 was downregulated and normal expression was restored, and in liver tissue, SAA1, SAA2, SAA3 were extremely expressed. After the addition of vitamin C, which has positive effects in several aspects, to the fecal microbiota transplantation, in the intestinal tissues, the genes that were highly expressed after the fecal microbiota transplantation effectively reduced their expression, and the unaffected genes remained normally expressed, but the CD74 gene remained highly expressed. In liver tissues, normally expressed genes were not affected, but the expression of SAA1 was reduced and the expression of SAA3 was increased. In other words, fecal microbiota transplantation did not necessarily bring about a positive effect of gene expression restoration, but the addition of vitamin C effectively reduced the effects of fecal microbiota transplantation and regulated the balance of the immune system.
Processo remoto de recrutamento e seleção: perspectivas e desafios em uma empresa de telecomunicações
Authors: Dos Santos Emilly Kalinne Aquino , Leite Francisco Fernando Pinheiro , Araújo Francisco Edmilson Dias , Do Nascimento José Shirley Pessoa , De Sousa Fernanda Soares
Published: May 2023

Este artigo teve como objetivo identificar a percepção dos candidatos à vagas em uma empresa de telecomunicações sobre as modalidades de seleção, os fatores favoráveis e limitantes no processo seletivo digital e, por fim, definir qual a preferência dos participantes em relação aos tipos de processos. Trata-se de uma pesquisa descritiva, de natureza qualitativa, desenvolvida a partir de um estudo bibliográfico e da aplicação de um questionário estruturado, com dados analisados a partir da perspectiva estatística e crítica. Os resultados anulam a hipótese da desvantagem e limitação na adoção da modalidade remota no desenvolvimento de processos seletivos. A percepção dos participantes da pesquisa indica a preferência pela modalidade remota, ainda que hajam desafios advindos, principalmente, do uso da tecnologia. Conclui-se que há potencial contribuição na utilização da modalidade remota, por parte das organizações, nos processos de recrutamento e seleção, agregando benefícios de logística e emocionais para as organizações e para os candidatos.
A Case of Oral Focal Mucinosis on Hard Palate: A Lesion Derived from the Periodontal Ligament
Authors: Pawane Iram Rafique , Rajasekar Arvina , Jayakumar Nadathur Doraisamy
Published: May 2023

Oral Focal Mucinosis (OFM) manifests on the gingiva as a painless mass, asymptomatic except for the presence of a fibrous mass, and is of the same colour as the surrounding mucosa. It is commonly reported on the gingiva. Histologically, it is characterised by focal myxoid degeneration of connective tissue. Its diagnosis seldom can be made clinically and predominantly relies on histopathological analysis. This case report is about a 40-year-old female who had a gradually increasing swelling on the palate in relation to upper right posterior teeth, for 4-5 months. The lesion was excised and sent for histopathological and immunohistochemical analysis. There was presence of foci of loose mucinous connective tissue stroma interspersed within dense connective tissue stroma. The mucinous stroma showed numerous stellate and spindle-shaped fibroblasts evident between thin collagen fibres with evidence of separation of collagen fibres.
Administration of Spinal Anaesthesia with Modified Paramedian Technique in a Patient with Kyphoscoliosis: A Case Report
Authors: Bhardwaj Yatharth , Singam Amol , Mago Vidur
Published: May 2023

Kyphoscoliosis is a condition that affects the spine, with adolescents accounting for 75-90% of cases of idiopathic scoliosis. Scoliosis patients may experience difficulties when receiving anaesthesia during surgical procedures. There is often multisystem involvement, including the cardiovascular, nervous, and respiratory systems. Patients who have scoliosis often have difficulties with their airways (affected airway morphology, difficult intubation with laryngoscopy), respiratory systems (hypoxia, alveolar vascular constriction, pulmonary hypertension), and cardiac systems (cardiomyopathy, right ventricular enlargement, but also cor pulmonale). Scoliosis can bring on a restrictive pulmonary disease, which can lead to a decrease in both total lung volume and functional residual capacity, as well as an increase in breathing rate. Owing to the deformities of the vertebra, subarachnoid blocks in patients with kyphoscoliosis generally constitute a special hurdle for the anaesthesiologist. Midline and paramedian approach for spinal anaesthesia has been practiced since long but a novel approach as modified paramedian technique allows the entry of the needle from far away from midline hence reducing the number of punctures taken and lesser complications. Respiratory and airway concerns are customarily addressed in kyphoscoliotic patients. Authors present a unique case of 35-year-old male with severe kyphoscoliosis with neurofibromatosis posted for right above knee amputation by spinal anaesthesia using modified paramedian technique. Authors planned for subarachnoid block for this patient with modified paramedian approach which resulted in right-sided dense block with patchy sensory and motor block on left-side. For a successful operation, scoliosis patients require a thorough preoperative evaluation, a well-equipped set-up, and a teamwork.
Utilization Pattern of TNAU Banana Expert System among Nendren Banana Growers in Kanyakumari District
Authors: Hassan S. Nazreen , Priya R. Swarna , Kavitha K. , Selvarani A. , Latha R. , Suresh S.
Published: May 2023

Use of Information and Communication Technology (ICT) for transmission of localized information and services has increased towards making farming socially, economically and environmentally sustainable by Digital Agriculture. Tamil Nadu Agricultural University (TNAU) has initiated a lot of efforts in digitizing agricultural information to reach the stakeholders. A few expert systems were developed to help farmers and specialists to diagnose plant diseases. The TNAU Banana expert system is one such mobile app, where a farmer can get all solution and information on banana cultivation in just one touch.  An experiment was conducted with 40 banana farmers of Kanyakumari district who form the respondents for the study. This paper analyses on Knowledge gain with the support of the TNAU Banana Expert system, which showed significant positive change. The number of technologies adopted above the average adoption level after demonstration was eleven. It was adopted by only 12.5% of farmers before using the App, while it was 62.5% after the demonstration. The overall increase in Knowledge gain over the existing level was 53.05%.
Micro Food Processing Enterprises of Andhra Pradesh: Growth Opportunities Using the PEST Analysis
Authors: Aneesh Akkineni , Mahendran K. , Rohini A. , Kumar D. Suresh , Duraiswamy M. R.
Published: May 2023

Aims: This study aims to use PEST analysis to comprehend the strategies implemented by micro food processing enterprises in Andhra Pradesh, India, with regard to political, economic, social, and technological factors to provide an overview of their growth potential.

Study Design: This study is designed as an observational study, utilizing both secondary and primary data.

Methodology: The study uses PEST analysis, which is a framework used to analyze and understand the external macro-environmental factors that affect an organization. Secondary data was obtained from the Andhra Pradesh Food Processing Society (APFPS), while primary data was collected from micro food processing enterprises in Andhra Pradesh.

Results: Based on the study's observations, it was found that the state government of Andhra Pradesh provides a favorable and friendly environment for initiating an enterprise by providing subsidies and incentives. Additionally, micro food processing enterprises adopt specific strategies to sustain competition. Andhra Pradesh was found to be the top South Indian state in net value-added products.
Instrument of Augmented Reality Technology Based Biology Practicum: Psychometrics Analysis
Authors: Wikanta Wiwi , Suharti Peni , Asy’ari
Published: May 2023

Digital literation skills are student’s need in nowadays modern era to refine the information accurately as an education media. Supporting the digital literation is by using the proper application by applying augmented reality (AR) technology. The purpose of the research is to analyze an implementation of AR technology as an effort to improve student’s digital literation skill in Surabaya senior high schools. The method of the research is quantitative with around 500 respondents that consist of students form three non-government senior high schools in Surabaya, Indonesia. The instruments validation to measure student’s acceptance towards AR technology as a teaching media is unexplored yet.  This study is to evaluate the questionnaire about AR technology towards digital literation skill. The questionnaire consists of 10 items by google form and sent by online to 500 students in Surabaya. The data is processed by statistics with data analysis using Exploratory and Confirmatory Factor analysis. The whole average scores of questionnaires point that analyzed descriptively around, 60 and 2.63 with deviation standard 0.52-0.77. The scores of Pearson correlation by the whole items is around 0.08 and 0.35. The measurement of sample fairness using Kaiser-Meyer-Olkin (KMO) analysis generate 0.796 (Primely). This study identified three dimensions of total variation explains 51.28% from 10 items. The whole items generate factor loading score 0.5. However there are 2 items that eliminated that is item 1 and item 2.
Business Plan and Implementation Report on Fashion Business “CAYNILV”
Authors: Sabira Rihab , Hartono Arif
Published: May 2023

This report was created with the aim of finding out how the fashion business can have a big impact on local products. The influence of brand awareness this can have an impact on the local industry where the product is made. Brand awareness is important to increase sales because the more people know about a brand, the more likely they will consider and buy the products offered by that brand. Strong brand awareness can help local fashion brands maintain their position in a competitive market and continue to expand their customer base. Caynilv become a local brand that can meet the fashion needs of all groups at affordable prices with characteristics or uniqueness and maintain quality. The results of this business implementation can be realized well, although some gaps have been resolved with solutions that refer to marketing management theory. Based on the results of observations and existing opportunities, business development will be carried out by expanding the market share of products by providing other more varied products. Thus, the products produced can be more varied, and the target market can be wider.
On Zero-Truncated Negative Binomial with Excess Ones
Authors: Jolayemi E. Teju , Aderoju S. A.
Published: May 2023

In this paper, Zero-truncated negative binomial distribution is modified to include excess ones to improve goodness-of-fit. This is necessary when data are dispersed and zero has been eliminated from data structurally. However, when the ones are unduly large, the proportion of this excess must be recognized and estimated to improve the fit. This development is applied using real data from a national survey.
Evaluation of Tillage and Mulch Practices on the Growth of Selected Cereal and Legume Crops in the Foothills Agro-ecological Zone of Lesotho
Authors: Molata Tumisang Richard , Mosebi Poloko , Oluremi Oluwabiyi Ikeolu Atanda , Molapo Setsumi
Published: May 2023

The trial was conducted to evaluate the influence of tillage and mulch practices on growth response of maize and selected forage legumes. With three replications, the experiment was carried out using a split-plot design. Mulch and no mulch were used as the major plot treatments Mulch was maize straw left from the previous cropping season. The subplot treatments were different tillage practices namely Minimum (0.2 m) and Deep tillage (0.35 m).The research was carried out in the Foothills of Lesotho in Ha-Matela in Nazareth, east of Maseru District, during summer season for four months (December, January, February, and March). A mouldboard plough was used to prepare the experimental field, and it was harrowed to get fine tilth. The broadcasting method was used to plant the legume species namely soybean (Glycine max L), lablab (Lablab purpureus L) and grazing vetch (Vicia villosa), whereas a planter was used to sow maize seeds at a rate of two per hole, 0.25 m apart, and 0.05 m deep. For maize and the forage legumes, 12.5 kg of NPK inorganic fertilizer was applied per plot. Low moisture content and poor soil conditions under minimum tillage and no-mulch resulted in low plant growth. Maize and forage legumes plant height was significantly (P<0.05) higher under deep tillage and mulch. Vegetative characteristics in respect of leaf, stem, and root lengths were also significantly (P<0.05) higher under deep tillage and mulch. Cereal maize had a low and positive correlation relationship between its growth indices whereas; legume crops had a high correlation relationship and were significant. Therefore, maize and forage legumes may be produced under deep tillage and mulch to support improved plant growth.
Efficacy of Spinosad 48SC on the Management of Cotton Bollworms Diparopsis castanea (Hubner) and Herlicoverpa amigera (Hampson) in Zimbabwe
Authors: Jimu F. , Mapuranga R. , Mubvekeri W. , Kutywayo D.
Published: May 2023

Bollworms management remains one of the major constraints to higher cotton productivity in Zimbabwe. Field trials to investigate the efficacy of Spinosad 48 SC on Diparopsis castanea (Hubner) and Herlicoverpa amigera (Hampson) were carried out for three seasons 2010/11 to 2013/14 at Cotton Research Institute, Kuwirirana, Umguza, and Chizvirizvi in Zimbabwe. A Randomised Complete Block Design with five treatments and four replications was used in this experiment. Three doses of Spinosad 48 SC 40ml/ha, 60ml/ha and 80ml/ha, were evaluated, along with Lambda cyhalothrin 5 EC at 200ml/ha as the standard treatment and the untreated control. Observations on bollworms eggs, larval counts and predator counts. The square root transformation of (x + 3/8) was used for data not following normal distribution. Data were analysed using Genstat 14th Edition. All the three doses of Spinosad 48 SC (40ml/ha, 60ml/ha and 80ml/ha) controlled Diparopsis castanea (Hubner) and Herlicoverpa amigera (Hampson) at CRI, Kuwirirana, Umguza and Chizvirizvi. The highest dose of Spinosad 48 SC of 80ml/ha resulted in the highest yield of seed cotton at CRI and Kuwirirana. All the three doses of Spinosad 48 SC killed predators in the same way as the standard insecticide. Spinosad 48 SC was recommended for registration on control of the two bollworms in Zimbabwe at 80ml/ha dose.
Oedometers tests in Compacted Tropical Soils in the State of Rio de Janeiro, Brazil
Authors: Ramos Viktor L. F. S. , Mahler C. F.
Published: May 2023

Oedometers and secondary oedometric tests with controlled shear rates were performed in two soils from the Baixada Fluminense region, in the city of São João do Meriti – Rio de Janeiro, Brazil. The soils in question are deposited on non-compacted soft soil with the addition of Municipal Solid Waste (MSW). Both samples of compacted soil were excavated at a depth of 10.0 m, and undisturbed samples were collected.
Soil Analytics: Inter-conversion of Units among Different Parameters in Soil Science
Authors: Stephen Oyatokun, Olukayode
Published: May 2023

Soil analytics involves a variety of chemical processes that determine that amount of available plant nutrients in the soil, including their physico-chemical and biological properties important for plant nutrition. The chemical analysis determines plant nutrients content and other physical characteristics. Based on quality soil analysis, it is easier to determine the required fertilizer needed by plants for quality growth and yield. Analytical procedures in soil science vary from one method to another, each with its peculiar unit of measurement. This article seeks to provide some inter-unit conversion or provide conversion factors to satisfy the yearnings of all interest groups. The calculation and conversion of units of measurement of different soil parameters will unify conclusions of different analytical results, such as in fertilizer application and experimental reactionary systems. The outcome of this article has provided meaningful inter- unit conversion through simple derivation principles, by the derivation of conversion factors, and in the practice of fertilizer calculation for fertility studies.
Comparative Analysis of the Effect of Different Insecticide Treatments on Nagpur Mandarin in Biomass Accumulation
Authors: Dawane P. N. , Prajapati Shailendra Sagar , Bagde Ekta Dinanath , Goramnagar H. B.
Published: May 2023

The Comparative Analysis of the Effect of Different Insecticide Treatments in Nagpur Mandarin on Biomass Accumulation was conducted during the Ambia bahar of 2009-10. The experiment was carried out on an eight-year-old Nagpur mandarin orchard with a spacing of 6.0 m x 6.0 m at Futala farm, College of Agriculture, Nagpur. The study aimed to assess the impact of different insecticide treatments on Citrus psylla management. A trial comprising of eleven treatments was set in the Randomized Block Design (RBD), replicated thrice, with each treatment plot having four plants. Four branches were selected from each plant at random and tagged. The population of citrus psylla (both nymph and adult) was counted on the twigs of 5 cm fresh growth of the shoot from all the four sides of the plant during Ambia bahar of 2009-2010. The study found that imidacloprid 0.25 ml/l, acetamiprid 0.1 g/l, and quinalphos 1 ml/l + karanj oil (pongamia oil) 10 ml/l were the most effective treatments based on biomass accumulation (wet weight basis). Meanwhile, treatments with lower efficacy were Verticillium lecani 4 g/l + mineral oil 5 ml/l, azadirachtin 2 ml/l, mineral oil 5 ml/l, and Verticillium lecani 4 g/l. Furthermore, the application of imidacloprid 0.25 ml/l, acetamiprid 0.1 g/l, thiomethoxam 0.1 g/l, and quinalphos 1 ml/l + karanj oil (pongamia oil) 10 ml/l were found to be the most effective treatments based on biomass accumulation on a dry weight basis. The results indicated that treatments with imidacloprid, acetamiprid, thiomethoxam, and quinalphos with karanj oil were the most effective in promoting higher growth of new flush, bearing (buds, flowers and fruit), and biomass accumulation on both wet weight and dry weight basis. Among them, the treatment with imidacloprid at 0.25 ml/l was found to be the most effective.
Stable Atrial Flutter in a Cocaine User: A Case Report and Literature Review
Authors: Mann Henry , Bastola Ambika Devi Kaphle , Arora Amita , Dolkar Tsering , Tbeile Rachel , Dufresne Alix
Published: May 2023

Cocaine is one of the commonest illicit drugs used and one of the most frequent causes of drug related deaths. Cardiovascular system effects due to cocaine manifests as a variety of structural heart issues along with arrhythmias. Atrial flutter is a common cause of morbidity in the United States population. Even though research has been sparse on the topic of cocaine use and atrial flutter, they have been shown to be linked. We present here a unique case of stable chronic atrial flutter in a middle-aged woman with a history of chronic cocaine use and heart failure with an ejection fraction of 15-20%.
The Role of Magnetic Resonance Imaging in the Diagnosis of Spinal Dumbell Neurofibromatosis: A Case Report from a Specialist Hospital in Port Harcourt
Authors: Wekhe Chidinma , Akagbue Vivian Ndidi
Published: May 2023

Neurofibromatosis occurring in the spine also known as spinal neurofibromatosis (SNF) is a rare disease entity and they occur either unilaterally or bilaterally at the spinal roots. The low prevalence rate of the disease and scarcity of previous literatures is the main aim for this report.

Our case study is a 29-years-old lady who presented to the Radiology department for a lumbosacral spine MRI, on account of both lower limb weakness, paresthesia, unsteady gait and finally inability to walk. The symptoms have been there since she was 14 years (15 years of progressive symptoms). She also presented with multiple macules on the skin (café au lait spots). Magnetic Resonance Imaging (MRI) of the lumbosacral spine revealed bilateral spinal neurofibromas at the spinal roots of the fourth lumbar vertebra to the sacral/coccygeal vertebrae with destruction of the sacro-coccygeal bones. MRI of the brain revealed no abnormalities in the brain and optic tract. The patient fulfilled the National Institutes of Health (NIH) criteria and that of revised diagnostic criteria for Neurofibromatosis (NF1).

The patient also presented with lack of pain which could be due to impairment in sensory neurons. We describe a case of spinal neurofibromatosis diagnosed by MRI in a young lady with progressive lower limb weakness, paresthesia, sensory loss, café-au- lait spots and paraplegia.
Results of Trial Transplanting of Oriental Tobacco Varieties in Dak Lak Province, Vietnam in 2022
Authors: Dung Đo Đinh , Chin Nguyen Van , Viet Bui Quoc , Van Nguyen Van , Tuan Tao Ngoc , Thanh Và Pham Ha
Published: May 2023

In 2022, the Vietnam Tobacco Institute continued to test 6 tobacco oriental varieties in Dak Lak province based on the test results of tobacco varieties, cultivation techniques, curing in Ninh Thuan and Dak Lak provinces in 2021. To determine the suitable growing areas and varieties of oriental tobacco for the Dak Lak region, we experimented with six oriental tobacco varieties, including Basma 16, Kozarsko, Hanski 227, Rila 89, Dupnitsa 733 và Basma X with a fertilizer rate of 40N: 30P2O5: 50K2O kg/ha. The variety experiment was designed with a completely randomized block, repeated 3 times with 50 m2/plot. The experimental results have determined Dak Lak region to be suitable for planting the oriental tobacco plants and have selected two of the property oriental varieties as Basma and Hanski 227. Those varieties were good growth, high yield and good quality. The quality of oriental tobacco production in Dak Lak region was quite good, equivalent to the imported samples which was been used by Vietnam’s factories. In the coming time, the Vietnam Tobacco Institute will continue to experiment and expand the oriental tobacco area in Dak Lak to provide materials for cigarette factories and limit imported tobacco from abroad.
Estimated Annual Spending on Lecanemab and Its Ancillary Costs in the US Medicare Program
Authors: Arbanas Julia Cave , Damberg Cheryl L. , Leng Mei , Harawa Nina , Sarkisian Catherine A. , Landon Bruce E. , Mafi John N.
Published: May 2023

This cross-sectional cost analysis uses data from the 2018 Health and Retirement Study to estimate the potential future Medicare spending and beneficiary costs for lecanemab.
Survival Outcomes in Patients With Hormone Receptor–Positive Metastatic Breast Cancer With Low or No ERBB2 Expression Treated With Targeted Therapies Plus Endocrine Therapy
Authors: Mouabbi Jason A. , Singareeka Raghavendra Akshara , Bassett Roland L. , Hassan Amy , Tripathy Debasish , Layman Rachel M.
Published: May 2023

Importance

Approximately 45% to 60% of hormone receptor (HR)–positive metastatic breast cancer (mBC) shows a low-level expression of ERBB2. Low ERBB2 expression is defined as ERBB2 immunohistochemical expression of 1+ or 2+ with a negative ERBB2 amplification by in situ hybridization. The efficacy of the antibody-drug conjugate trastuzumab deruxtecan in low-ERBB2, HR-positive mBC has been practice changing. However, there are conflicting data on the prognostic value of low ERBB2 expression in HR-positive mBC and whether low ERBB2 expression is a separate entity.

Objective

To examine whether outcomes differ by immunohistochemical analysis for patients with HR-positive mBC with low ERBB2 expression vs those without ERBB2 expression when treated with targeted therapy (TT) plus endocrine therapy (ET).

Design, Setting, and Participants

This single-institution cohort study used prospectively collected electronic data from the MD Anderson Cancer Center for patients with a diagnosis of HR-positive mBC treated with ET in combination with a TT (cyclin-dependent kinase 4/6 inhibitors [CDK4/6is], everolimus, or alpelisib) between January 1, 2010, and December 31, 2021.

Exposure

HR-positive mBC with either low or no ERBB2 expression.

Main Outcome and Measures

The main outcomes were median progression-free survival and overall survival. Data on demographic characteristics, estrogen and progesterone receptor status, ERBB2 status, histologic subtype, menopausal status, treatment duration, and survival status were collected.

Results

A total of 1585 women (median [range] age, 51 [24-92] years) were included in the study. Of these women, 1013 (63.9%) had mBC with low ERBB2 expression and 572 (36.1%) had mBC with no ERBB2 expression. A total of 1084 (68.4%) were treated with a CDK4/6i (912 patients were treated in the first line and 172 were treated in the second line); 475 (30.0%) received everolimus and 26 (1.6%) received alpelisib. In the patients who received a first-line CDK4/6i, 618 (67.8%) received an aromatase inhibitor as their ET backbone and 265 (29.1%) received fulvestrant. With a median follow-up time of 17.9 months (range, 1-111 months), progression-free survival and overall survival were not statistically different between the patients with low and no ERBB2 expression treated with TT plus ET.

Conclusions and Relevance

In this cohort study of patients with HR-positive mBC treated with TT plus ET, low ERBB2 expression did not have a significant association with prognosis.
Association of Serious Adverse Effects With the Contamination of Ocular Medications—A Global Perspective
Authors: Prajna N. Venkatesh , Radhakrishnan Naveen , Prajna Lalitha
Published: May 2023

This Viewpoint offers examples of the causes of infectious keratitis around the world and emphasizes the need for vigilance among ophthalmologists to reduce the risk of sight-threatening complications.
Association of Backscattered Ultrasonographic Imaging of the Tongue With Severity of Obstructive Sleep Apnea in Adults
Authors: Liu Stanley Y. C. , Bosschieter Pien F. N. , Abdelwahab Mohammed , Chao Pei-Yu , Chen Argon , Kushida Clete
Published: May 2023

Importance

Determining interventions to manage obstructive sleep apnea (OSA) depends on clinical examination, polysomnography (PSG) results, and imaging analysis. There remains the need of a noninvasive and cost-effective way to correlate relevant upper airway anatomy with severity of OSA to direct treatment and optimize outcome.

Objective

To determine whether backscattered ultrasonographic imaging (BUI) analysis of the tongue is associated with severity of OSA in adults.

Design, Setting, and Participants

In this prospective, single-center, diagnostic study of a consecutive series of patients (aged ≥18 years) at a sleep surgery clinic, the 89 included patients had a PSG within 3 years at the time of ultrasonography and BUI analysis between July 2020 and March 2022. Patients were excluded if body mass index had changed more than 10% since time of PSG. A standardized submental ultrasonographic scan with laser alignment was used with B-mode and BUI analysis applied to the tongue. The B-mode and BUI intensity were associated with the apnea-hypopnea index (AHI), a measure of severity of apnea from normal (no OSA) to severe OSA.

Exposures

Ultrasonography and PSG.

Main Outcomes and Measures

The main outcomes were BUI parameters and their association with AHI value.

Results

Eighty-nine patients were included between July 2020 and March 2022. A total of 70 (78.7%) male patients were included; and distribution by race and ethnicity was 46 (52%) White participants, 22 (25%) Asian participants, and 2 (2%) African American participants, and 19 (21%) others. Median (IQR) age was 37.0 (29.0-48.3) years; median (IQR) BMI was 25.3 (23.2-29.8); and median (IQR) AHI was 11.1 (5.6-23.1) events per hour. At the middle to posterior tongue region, the 4 OSA severity levels explained a significant portion of the BUI variance (η2 = 0.153-0.236), and a significant difference in BUI values was found between the subgroups with AHI values of less than 15 (no OSA and mild OSA) and greater than or equal to 15 (moderate OSA and severe OSA) events per hour. The echo intensity showed no significant differences. The BUI values showed a positive association with AHI, with a Spearman correlation coefficient of up to 0.43. Higher BUI values remained associated with higher AHI after correction for the covariates of BMI and age.

Conclusions and Relevance

In this prospective diagnostic study, standardized BUI analysis of the tongue was associated with OSA severity. With the practicality of ultrasonography, this analysis is pivotal in connecting anatomy with physiology in treatment planning for patients with OSA.
A combined radiomic model distinguishing GISTs from leiomyomas and schwannomas in the stomach based on endoscopic ultrasonography images
Authors: Zhang Xian‐Da , Zhang Ling , Gong Ting‐Ting , Wang Zhuo‐Ran , Guo Kang‐Li , Li Jun , Chen Yuan , Zhang Jian‐Tao , Ye Ben‐Gong , Ding Jin , Zhu Jian‐Wei , Liu Feng , Hu Duan‐Min , Chen JianGang , Zhou Chun‐Hua , Zou Duo‐Wu
Published: May 2023

Background

Endoscopic ultrasonography (EUS) is recommended as the best tool for evaluating gastric subepithelial lesions (SELs); nonetheless, it has difficulty distinguishing gastrointestinal stromal tumors (GISTs) from leiomyomas and schwannomas. GISTs have malignant potential, whereas leiomyomas and schwannomas are considered benign.

Purpose

This study aimed to establish a combined radiomic model based on EUS images for distinguishing GISTs from leiomyomas and schwannomas in the stomach.

Methods

EUS images of pathologically confirmed GISTs, leiomyomas, and schwannomas were collected from five centers. Gastric SELs were divided into training and testing datasets based on random split‐sample method (7:3). Radiomic features were extracted from the tumor and muscularis propria regions. Principal component analysis, least absolute shrinkage, and selection operator were used for feature selection. Support vector machine was used to construct radiomic models. Two radiomic models were built: the conventional radiomic model included tumor features alone, whereas the combined radiomic model incorporated features from the tumor and muscularis propria regions.

Results

A total of 3933 EUS images from 485 cases were included. For the differential diagnosis of GISTs from leiomyomas and schwannomas, the accuracy, sensitivity, specificity, and area under the receiver operating characteristic curve were 74.5%, 72.2%, 78.7%, and 0.754, respectively, for the EUS experts; 76.8%, 74.4%, 81.0%, and 0.830, respectively, for the conventional radiomic model; and 90.9%, 91.0%, 90.6%, and 0.953, respectively, for the combined radiomic model. For gastric SELs <20 mm, the accuracy, sensitivity, specificity, and area under the receiver operating characteristic curve of the combined radiomic model were 91.4%, 91.6%, 91.1%, and 0.960, respectively.

Conclusions

We developed and validated a combined radiomic model to distinguish gastric GISTs from leiomyomas and schwannomas. The combined radiomic model showed better diagnostic performance than the conventional radiomic model and could assist EUS experts in non‐invasively diagnosing gastric SELs, particularly gastric SELs <20 mm.
In Situ Construction of Ni/Ni0.2Mo0.8N Heterostructure to Enhance the Alkaline Hydrogen Oxidation Reaction by Balancing the Binding of Intermediates
Authors: Huang Churong , Feng Min , Peng Yang , Zhang Bin , Huang Jingle , Yue Xin , Huang Shaoming
Published: May 2023

The inferior activity of hydrogen oxidation reaction (HOR) in alkali severely hampers the deployment of Ni catalysts in the promising anion exchange membrane fuel cells (AEMFCs), due to the unbalanced binding energies of hydrogen (HBE) and hydroxyl (OHBE) species. Ni‐Mo alloy and nickel nitride have been proven to improve the Ni‐based activities of HOR but they still can be further enhanced. Because it sacrifices the HBE for enlarging OHBE. Herein, it is reported that the activity can be further improved by constructing heterostructure between Ni nanoparticles (NPs) and nitride of Ni‐Mo alloy (Ni0.2Mo0.8N) by an in situ synthetic strategy. The in situ prepared reduced graphene oxide (rGO) supported heterostructure (Ni/Ni0.2Mo0.8N/rGO) possesses the state‐of‐the‐art activity (overpotential of 100 mV to achieve 2.9 mA cm−2), faster kinetics (kinetics current density of 11.20 mA cm−2 and exchange current density of 2.74 mA cm−2), and ultrahigh durability (maintaining the current densities for over 40 h or 10000 cycles). Detailed characterizations together with density functional theory simulations reveal that the tuned d‐band electronic structures optimize and balance the HBE and OHBE, facilitating the HOR process on the as‐fabricated heterostructured catalyst.
Delicately Designed Cyano‐Siloxane as Multifunctional Additive Enabling High Voltage LiNi0.9Co0.05Mn0.05O2/Graphite Full Cell with Long Cycle Life at 50 °C
Authors: Ren Zhongqin , Qiu Huayu , Fan Cheng , Zhang Shenghang , Zhang Qingwei , Ma Yinglei , Qiao Lixin , Wang Shitao , Xu Gaojie , Cui Zili , Cui Guanglei
Published: May 2023

Lithium‐ion batteries (LIBs) adopting layered oxide cathodes with high nickel content (Ni ≥ 0.9) always suffer from extremely poor cycle life, especially at elevated temperatures and higher charging cut‐off voltages. Adding small amounts of functional additives is considered to be one of the most economic and efficacious strategies to resolve this issue. Herein, cyano‐groups are introduced innovatively into a siloxane to delicately synthesize a novel cyano‐siloxane additive, namely 2,2,7,7‐tetramethyl‐3,6‐dioxa‐2,7‐disilaoctane‐4,4,5,5‐tetracarbonitrile (TDSTCN). Encouragingly, 0.5 wt.% TDSTCN additive enables ultrahigh nickel LiNi0.9Co0.05Mn0.05O2/graphite (NCM90/Gr) full cells with dramatically increased cycle life, especially at an elevated temperature of 50 °C and a high charging cut‐off voltage of 4.5 V. The characterizations reveal that the TDSTCN additive can scavenge HF and promote the formation of robust stable interface layers on NCM90 cathode and Gr anode due to the synergistic effects of cyano‐groups and Si−O bonds. These results reveal the great significance of designing one single additive with several functional groups in enhancing the comprehensive electrochemical performances of high Ni LIBs.