bluuebunny/crossref_metadata_2025 huggingface dataset:
The COVID-19 silver lining for speech and language therapists working in intensive care units
Authors: Mills Claire S. , Jones Gemma , Wallace Sarah
Published: November 2022

The COVID-19 pandemic has been a dark cloud for all, but particularly for healthcare workers. However, despite the many challenges and stresses faced, speech and language therapists working in intensive care units in the UK have found a silver lining. This “Spotlight on: The COVID-19 silver lining for speech and language therapists” outlines some of these positive outcomes including: the increased recognition of the SLT role, increased visibility, improved services, increased productivity, and a promising future. By recognising and celebrating some of the positive developments made during the pandemic we can continue to work to ensure equity of provision for all patients in intensive care.
Research on Carbon Dioxide Emission Reduction Accounting Method and Carbon Peak Path Design of New Energy Vehicles in China
Authors: Sun Shuang , Wang Li , Han Qingwen , Li Shuaihua
Published: November 2022

The transportation industry is the second largest energy consumption sector in China and has become the main contributor to greenhouse gas emissions and air pollutants. To support the low-carbon development of the automobile industry, China has taken measures to replace traditional fuel vehicles with new energy vehicles. The reduction of carbon dioxide emission of new energy vehicles model is estimated in this paper, in which the driving situation, per 100km energy consumption, proportion of clean energy, gasoline emission factor and national average grid emission factor, etc. are all considered. The annual carbon dioxide (CO2) emission of a new energy vehicle is 2.24 tons and the annual emission reduction is 1.09 tons in 2020. Through correlation analysis, it is concluded that there is a high negative correlation between the average emission factor of the power grid and the proportion of green energy, and the correlation coefficient is −0.9662. The ownership of civil vehicles will be 457.16 million vehicles in 2030, and it will get to its peak in 2050. Besides, the peak of CO2 emission of civil vehicles will be got in 2030. Moreover, new energy vehicles charring new energy electricity is an effective way for the automotive industry to achieve carbon peak and carbon neutralization.
Residual Stress Analysis of Solid Oxide Fuel Cells with Functional Gradient Material Electrodes
Authors: Ma Shuai , Xue Dingxi , Li Qiangqiang , Li Guojun , Feng Chongyang
Published: November 2022

In this paper, an anode and cathode material scheme with a continuous gradient variation of components is presented. The residual stress distribution of each part of the electrode model under the new material structure is derived by calculating the residual stress during the sintering process, and the optimal material component distribution curve is derived from the analysis of the results. A multi-physics 3D model covering heat transfer, mass transfer, flow, electrochemistry and solid mechanics is developed with the help of the finite element analysis software COMSOL Multiphysics 5.5. Simulation experiments are conducted to verify the effectiveness of the method for mitigating thermal stress mismatch, reducing residual stresses and increasing the working life of the fuel cell. The results show that the use of functional gradient materials for one side electrode significantly reduces the residual stresses generated in the other side electrode during sintering, and the effect of the sinusoidal distribution curve is the most significant. The stress concentration at the electrode-electrolyte interface can be improved when both side electrodes are used with functional gradient materials at the same time, and the sinusoidal and primary linear distributions are more effective.
Research on the Effectiveness of Wind Turbine Blade Repairing Based on the Hole Drilling and Adhesive Injection Approaches
Authors: Wang Bingjia , Han Yi , Tong Bo , Zhang Yidong , Xie Xiaojun , Zhao Yong
Published: November 2022

With the increase of the thickness of the main beam of the wind turbine blade, the lack of glue between the thickest area of the main beam and the web after the blade is clamped has become an important issue that affects the quality of the blade, product production cycle, and repair cost. The traditional glue deficiency repair method has high technical requirements, and the quality after repair cannot meet the design requirements, so this study designed a new glue deficiency repair method. According to the requirements of the wind turbine blade web bonding process, through defect analysis, simulation calculation and test, etc., this paper analyzes the repair method of punching holes in the main beam when the web is glued and lacking, which affects the strength of the wind turbine blade main beam and the bonding performance of the web.
Study on Bubble Dynamic Characteristics of Lead-Bismuth Alloy Under Natural Circulation
Authors: Liu Zhanzhong , Li Guojun
Published: November 2022

In order to guide the practical application of lead-bismuth alloy (LBE) bubble lift pump, the dynamic characteristics of nitrogen bubbles with different diameters in liquid Lead-bismuth alloy (LBE) were studied based on the Volume of Fluid (VOF) model, and the changes of bubbles’ morphology and velocity during the movement were analyzed. The results show that the smaller the radius of the bubble is, the more drastic the change of its initial velocity and the smaller its maximum velocity are. For the small bubble, there is no bubble shedding in the process of its movement, only when the radius of the bubble reaches a certain value, the phenomenon of small bubble shedding will occur.
Study on the Properties of Lauric Acid Paraffin Wax Volcanic Rock Shape-Stabilized Phase Change Materials
Authors: Wang Fang , Xiao Lixian , Wang Jianqiu , He Yongtai
Published: November 2022

Taking lauric acid-paraffin wax (LA-PW) volcanic rock (VR) shape-stabilized phase change materials with particle sizes of 1–3mm and 4–6mm as the research objects, analysis was made on the enthalpy, infrared spectrum, leakage characteristics, heat storage, heat release of shape-stabilized phase change materials. The results show that shape-stabilized phase change material has lower enthalpy with the increase in mass fraction of volcanic rock, but the material melting point and freezing point remain basically unchanged, and the shape-stabilized phase change material does not produce new substances, displaying stable composition. It can be seen from the leakage characteristics that, under the same ratio, shape-stabilized phase change material with a volcanic rock particle size of 1–3 mm has greater thermal stability than that with a volcanic rock particle size of 4–6 mm.
The Analysis on Controlbox Mal-Operation Resulting from Secondary Circuit’s Mistaken Wiring
Authors: Qiao Kai , Liu Nina , Hui Jie , Xie Yongqiang
Published: November 2022

The paper presents an application instance of CZX-22A controlbox mal-operation from secondary circuit’s mistaken wiring, and analyzes academic reason of controlbox mal-operation in detail. Mistaken wiring leads to DC source parataxis existing in the breaker control circuit, when one route control source is broken down for some reason, it could result in controlbox mal-operation and the accidental trip. By experiment and calculation, this paper brings forward a view of preventing controlbox mal-operation, which alters components’ parameters on circuit board of controlbox, thus ensuring the reliability of relaying protection and the security of the grid.
Comparison and Analysis of Virtual Power Plant and Peer-to-Peer Transaction Applied to Distributed Generation Market Transaction in China
Authors: Jiang Guodong , Han Tao , Du Hongwei , Niu Xiaojun , Wu Xueqiong , Feng Rongqiang , Xia Dong , Li Yuhang
Published: November 2022

firstly, this paper analyzes the necessity of market transaction of distributed generation, and summarizes the current situation of distributed generation transaction in the world. Then it discusses and analyzes the relevant policies of the Chinese government for distributed generation transaction, including photovoltaic subsidy policies, support policies for virtual power plants to participate in power trading, and support policies for distributed generation transaction pilot projects. According to China’s current electricity market rules and distributed generation transaction support policies, a distributed generation transaction platform system suitable for Chinese electricity market is designed based on blockchain technology. This paper compares and analyzes the two modes of virtual power plant and peer-to-peer transaction from the aspects of DG investor’s revenue and trading model. Finally, for the development of distributed generation trading in China, we draw conclusions and suggestions, and put forward the problems to be solved in the next step.
Intelligent Prediction and Experimental Study on Deep Peak-Regulation Capability of Thermal Power Units
Authors: Fu Xuchen , Duan Lunbo , Wang Yankai , Han Yi , Yu Yingli
Published: November 2022

The rapid increase in renewable energy has put forward higher requirements for the peak-shaving capacity of coal-fired power plants. Intelligent prediction of the deep peak-regulating capacity of thermal power units can effectively explore the peak-regulating potential of the units. The ultra-low load steady combustion experiment is an effective verification of the minimum steady combustion load of the units, and also an important basis for evaluating the deep peak-regulating capacity. In this study, an intelligent prediction method combining numerical combustion simulation with hydrodynamic safety calculation is proposed to adapt to peak regulating requirements. The intelligent prediction method is used to predict that the 300MW boiler can be reduced to 25% turbine heat acceptance (THA) load and stable combustion in actual operation, the results are verified by the field low-load stable combustion experiment. The results show that: The method is used during the declining load include leveling deviation of primary air velocity and reducing the primary air velocity appropriately, commissioning adjacent burners, closing the perimeter air, reducing the operating oxygen volume while reducing the secondary air volume is beneficial to improve the low load stable combustion ability. At the same time, the main and auxiliary systems of the boiler are stable, safe, environmentally friendly, and have strong operation guarantee ability.
Cause Analysis and Improvement Measures of 35kV Dry Hollow Reactor Burning Failure
Authors: Liu Nina
Published: November 2022

Dry hollow reactor has been widely used in China due to its advantages of simple structure, low price and basic maintenance-free. But after a long time of operation, dry reactor burning accidents frequently appear. Taking the 35kV reactor burning accident on the low-voltage side of the main transformer of a substation as an example, this paper analyzes the protection action behavior and fault recording point of the reactor in view of the reactor fire caused by the failure of the protection device in the early stage of the fault, and puts forward a theoretical analysis method of reactor fault. At the same time, the protection configuration of dry hollow reactor in current engineering application is discussed, and corresponding measures and suggestions are put forward from the aspects of protection configuration optimization, reactor design, operation and maintenance to prevent reactor accidents.
Study on Ecological Restoration Technology of Slope for Power Transmission and Transformation Facilities
Authors: Chen Yao , Jiang Shixiong , Li Xi , Wang Chongqing , Che Yanhong , Weng Sunxian , Chen Zeqin
Published: November 2022

With the rapid development of urbanization, man-made geological disasters are increasing, and the slope problem has attracted more and more attention. However, the current slope restoration technology is difficult to achieve lasting greening under natural conditions. Given the problems existing in slope protection of power transmission and transformation projects, this study summarizes three principles of plant selection for slope protection, proposes a slope ecological restoration and degradation remediation technology, and applies it to the slope reinforcement project of a 220kV transmission tower in Zhangping City, Longyan City. Comparing the pictures before and after restoration, it can be seen that the method has achieved excellent ecological restoration effects. The content of this study provides powerful help for the restoration of engineering slopes in Fujian Province, and can also provide a reference for the restoration of slopes in other areas.
Care living instrument for neonatal infant connectivity solution (CliNicS) in smart environment
Authors: Sivasankari B. , Ahilan A. , Jeyam A. , Jasmine Gnanamalar A.
Published: November 2022

Hyperbilirubinemia or jaundice occurs in 60% of healthy babies and 80% of preterm infants because of an increase in unconjugated bilirubin in red blood cells. It is subjective to determine the severity of jaundice by visual assessment of the skin color of a newborn, and clinical judgement is dependent on the doctor’s knowledge. The paper explains the development of a non-invasive bilirubin detection technique called CliNicS, to check the bilirubin level of premature babies and report premature births and deaths to the health organization via an IOT network. CliNicS provides a noninvasive, transcutaneous bilirubin monitoring system using LED having a wavelength of 410 nm to 460 nm, and it also provides the treatment automatically by using LCT (LED Controlled Therapy) method. The level of bilirubin will be detected by using the photo detector, and the bilirubin measurement will be displayed on the LCD display. The bilirubin levels will be transmitted to doctors and health organizations via the IOT network. The proposed method helps to detect neonatal jaundice earlier, which reduces the risk of hyperbilirubinemia in newborns and makes it easier to measure total serum bilirubin levels than ever before.
A Novel Fault Diagnosis Method Based on MADCNN for Rolling Bearings
Authors: Gao Yangde , Piltan Farzin , Ahmad Zahoor , Toma Rafia Nishat , Kim Jong-Myon
Published: November 2022

Rolling bearings are treated as important machinery power components, faults of rolling bearings affect machinery operation, so an intelligent fault diagnosis method is very useful of safety operation in rolling bearings. This paper proposes a novel fault diagnosis method based on improved Adaptive Deep Convolution Neural Networks algorithm to realize fault recognition for rolling bearings. First, the Continuous Wavelet Transform (CWT) method is applied to the time-frequency decomposition of vibration signals and extract feature information images for training and testing. Second, to further improve self-learning ability of the Adaptive Deep Convolution Neural Network (ADCNN) in feature images, the Multiple Channels ADCNN method is proposed to classify different fault image types for the rolling bearing. Finally, fault images corresponding to different health states of the rolling bearing are applied to the proposed method, the experiment proves that the proposed method has a better performance for fault recognition in rolling bearings.
Improving Anomaly Detection in IoT-Based Solar Energy System Using SMOTE-PSO and SVM Model
Authors: Lin Liang-Sian , Chen Zhi-Yu , Wang Yu , Jiang Li-Wei
Published: November 2022

A large number of sensors based on Internet of Things (IoT) technology are now widely deployed in artificial intelligence, health care monitoring, air quality monitoring, and other fields. The sensors require high power consumption for real-time monitoring data. Some studies have suggested using solar energy for the primary power source to operate sensors. However, due to uncertain climate change, solar energy supply cannot always provide sufficient voltage to operate sensors. Consequently, some abnormal behavior events frequently occur in the IoT system using solar energy. Abnormal detection is a typical imbalanced learning problem due to the very rare amount of abnormal events. Under such data with skewed class distribution, classic classification models fail to provide reliable classification results with abnormal events. Under this condition, in this paper, deploying solar energy supply, we developed an IoT-based system using Arduino Microcontroller and Banana Pi, in which, the SMOTE-PSO algorithm is utilized to improve classification accuracies on abnormal event data in our system. Finally, two types of SVM kernel functions are used to verify classification capability in the developed IoT system.
An Entropic Approach to Technology Enable Learning and Social Computing
Authors: Alves Victor , Miranda José , Dawa Hossam , Fernandes Filipe , Pombal Fernanda , Ribeiro Jorge , Fdez-Riverola Florentino , Analide Cesar , Vicente Henrique , Neves José
Published: November 2022

Understanding one’s own behavior is challenging in itself; understanding a group of different individuals and the many relationships between these individuals is even more complex. Imagine the amazing complexity of a large system made up of thousands of individuals and hundreds of groups, with countless relationships between those individuals and groups. However, despite this difficulty, organizations must be managed. Indeed, ultimately the organization’s work is done by people, individually or collectively, alone or in combination with technology. Therefore, organizational behavior management is the central task of management work – it involves understanding the behavior patterns of individuals, groups, and organizations, predicting what behavioral reactions will be elicited by various managerial actions and finally applying this understanding. Undeniably, society’s work is often done by organizations, and the role of management is to make organizations do that work. Without it, our entire society would quickly stop operating. Not only would the products you have come to know and love swiftly to evaporate from store shelves; food itself would suddenly become scarce, having drastic effects on huge numbers of people. To this end, the term Technology- Enhanced Learning is used to support workers’ learning about technology; the gap between what is understood to be satisfactory and the current level of knowledge of the workforce is addressed by a Logic-programming-based Social Computing Framework entitled An Entropic Approach to Knowledge Representation and Reasoning, which relies on computational structures built on Artificial Neural Networks and Cases -based Thinking, as well as predictions and/or assessments, to empower the level of knowledge of the employees, here in technology, later in other areas.
Pelatihan Geogebra: Pemodelan Matematika Menggunakan Kalkulus
Authors: Lakapu Meryani , Fernandez Aloysius Joakim , Uskono Irmina Veronika , Jagom Yohanes Ovaritus , Dosianaeng Wilfridus Beda Nuba
Published: November 2022

Di masa pandemi covid-19, semua orang mempunyai kesempatan yang bebas untuk belajar berbagai hal dan di mana saja. Oleh karena itu, kegiatan pengabdian ini memberikan keluasan kepada seluruh mahasiswa/guru/dosen matematika di Indonesia untuk belajar tentang Pemodelan Matematika menggunakan Kalkulus, yang dibantu oleh aplikasi GeoGebra. Kegiatan ini merupakan kerjasama antara Himpunan Matematika Indonesia (IndoMs), Program Studi Pendidikan Matematika Sanata Dharma, Program Studi Matematika Universitas Kristen Satya Wacana dan Program Studi Pendidikan Matematika Universitas Katolik Widya Mandira. Peserta dalam kegiatan ini berjumlah 62 (mahasiswa, guru dan dosen) yang berasal dari 15 Kampus dan 5 Sekolah Menengah yang tersebar di seluruh Indonesia. Tujuan dari pelatihan ini adalah peserta dapat: (1) memahami konsep dasar pemodelan menggunakan kalkulus; (2) mengajukan masalah sehari-hari yang dapat dimodelkan dengan kalkulus; (3) mampu menggunakan geogebra dalam menyelesaikan dan menganalisa pemodelan matematis; dan (4) mampu mengkomunikasikan hasil pemodelan matematis dalam bentuk tulisan maupun lisan secara terstruktur. Berdasarkan hasil evaluasi, kegiatan ini dapat terlaksana dengan baik dan tujuan yang diharapkan tercapai
Terapan Pengelasan GMAW APLIKATIF Masyarakat Kayang Makmur Desa Bader Kab. Madiun
Authors: Indarto Yuwono  , Alfi Tranggono Agus Salim  , Wida Yuliar Rezika  , Rakhmad Gusta Putra  , Deby Griselda Lutfia Atallah  , Moch.Isro’Oktaviyanto  , Wahyu Eko Prasetyo  , Halimatus Sa’diyah
Published: November 2022

Kurangnya pemahaman terkait kreativitas dan inovasi tentang peralatan pertanian. Hal ini berdampak pada beberapa masalah keterampilan dan pendidikan di masyarakat Dusun Kayang Makmur, Desa Bader khusus nya di sektor pertanian yang sebagian besar telah menggunakan peralatan pertanian. Kurangnya penanganan dan keterampilan serta ketidakmampuan masyarakat dalam memperbaiki alat pertanian, mengakibatkan peralatan pertanian belum mampu dimanfaatkan dengan optimal. Alat pertanian dimanfaatkan dengan optimal jika perawatannya diperhatikan dengan baik, misalnya setelah pemakaian dilakukan pembersihan dan pengecekan alat secara berkala. Alat pertanian yang terbuat dari besi dan baja membutuhkan perawatan dan perbaikan dalam bentuk pengelasan. Sebelum melakukan pengelasan hal yang harus diperhatikan adalah prosedur pengelasan yang benar seperti instalasi alat yang tepat, posisi pengelasan yang benar serta pemahaman Kesehatan dan Keselamatan Kerja (K3) sehingga efektifitas pengelasan mudah dicapai dan mitra faham tentang prosedur pengelasan, instalasi alat, kesehatan dan keselamatan kerja (K3). Hasil Kegiatan yang didapatkan mitra adalah mampu mengelola dan mengembangkan kreatifitas serta inovasi, sehingga produk yang dibuat dapat meningkatakan keterampilan masyarakat.
Pelatihan Teknologi Akuaponik Dengan Sistem Budikdamber Sebagai Upaya Menumbuhkan Minat Budi Daya Pada Remaja
Authors: Ulfah Iin Khoiriyah , Prasetyo Mohammad Ageng , Maulana Recky Indar
Published: November 2022

Seiring berkembangnya teknologi, terdapat berbagai macam inovasi sistem budi daya bermunculan. Akuaponik merupakan gabungan teknologi budi daya ikan dan tanaman dalam satu wadah. Dibandingkan dengan budi daya konvensional, teknologi akuaponik memiliki lebih banyak keunggulan. Sayangnya, kemajuan teknologi ini tidak sejalan dengan ketersediaan sumber daya manusia yang mumpuni. Remaja yang menjadi tonggak kemajuan sering menganggap bahwa pertanian dan perikanan adalah pekerjaan para orang tua sehingga tidak sesuai dengan mereka. Oleh karena itu, pelatihan akuaponik dengan sistem Budikdamber ini diselenggarakan dengan mengajak remaja di Desa Jambewangi untuk dapat meningkatkan pengetahuan tentang cara budi daya ikan dan tanaman yang terintegrasi melalui sosialisasi dan praktik lapangan. Tujuannya adalah untuk menumbuhkan minat budi daya sehingga dapat turut andil dalam pengembangan inovasi terhadap potensi yang dimiliki daerahnya. SDM yang cerdas, berdaya guna dan berpotensi dapat memaksimalkan segala potensi dan kesempatan di sekitarnya, karena SDM yang berkualitas merupakan faktor penting dalam kemajuan suatu bangsa.
Implementasi Teknologi UMKM Resource Planning pada Industri Kreatif Batik di Desa Pujerbaru, Maesan untuk meningkatkan Kualitas dan Manajemen Sumber Daya
Authors: Adnan Fahrobby , Puspita Yeni , Ariefianto Lutfie
Published: November 2022

Desa Pujerbaru merupakan desa yang terletak di Kec Maesan, Kab. Bondowoso. Desa Pujerbaru merupakan sentra industri pembuatan kerajinan batik. Hal ini didukung dan dilatar belakangi oleh pelatihan pembuatan kerajinan batik yang diadakan Lembaga Pusat Kegiatan Belajar Masyarakat (PKBM). Warga desa diberikan ilmu dan pengetahuan tentang pembuatan kerajinan batik mulai dari batik tulis maupun batik tenun. Industri rumah kreatif Kerajinan Batik yang berada di Desa Pujerbaru telah mendapatkan prospek positif dari pemerintah desa dan permintaan pasar. Berdasar hasil analisis situasi dan observasi lapangan yang dilakukan pada mitra, didukung dengan data Lembaga Penelitian dan Pengabdian Masyarakat Universitas Jember(LP2M-UNEJ, 2021), maka permasalahan umum para penggiat Industri Kreatif Kerajinan Batik di Desa Pujerbaru adalah sebagai berikut : jenis produk hasil kerajinan antar pengrajin memiliki kesamaan satu sama lain, pemasaran dan penjualan dilakukan sendiri – sendiri oleh setiap pengrajin melalui toko retail yang tersebar dan promosi pada event yang diadakan oleh Pemerintah Kabupaten Bondowoso serta, penentuan jumlah produksi jenis kerajinan batik tidak sesuai dengan permintaan pasar, sehingga sering terjadi kelebihan produksi ataupun kekurangan produksi yang menyebabkan tidak terpenuhinya kebutuhan pasar. Menanggapi berbagai permasalahan kompleks yang dialami oleh mitra, maka tim pengusul pengabdian merumuskan solusi yang dapat mengatasi permasalahan mitra. Solusi yang diusulkan oleh tim pengusul adalah sebuah teknologi informasi yang disebut “UMKM Resources Planning Technology”. Solusi teknologi ini dirancang khusus agar mampu mengatasi setiap permasalahan pada mitra. Memaksimalkan keahlian para pengrajin agar tetap produktif dan semakin variatif pada jenis produk yang dihasilkan, dan mengelola agar jenis/varian produk yang dihasilkan setiap pengrajin memiliki keunikan tersendiri serta membantu pemasaran produk mitra
Obesity and changes of alkaline phosphatase activity in the small intestine of 40- and 80-day-old rats subjected to early postnatal overfeeding or monosodium glutamate.
Authors: Mozeš Š , Šefčíková Z , Lenhardt Ľ , Raček Ľ
Published: November 2022

To investigate the relationship between development of obesity and the small intestinal functions two experimental models of male Wistar rats were used in the present work: 1) early postnatally overfed rats, nursed from birth to weaning in small litters (SL, 4 pups/nest), and 2) neonatally monosodium glutamate treated rats (MSG 2 mg/g b.w. administered s.c. for 4 days after birth) submitted to the same early nutritional manipulation. After weaning, all animals had free access to a standard pellet diet and at 40 and 80 days of age their body weight, body fat content and food consumption as well as changes of the brush-border-bound duodenal and jejunal alkaline phosphatase (AP) activity were compared with parameters of the offsprings raised under normal feeding conditions (NL, 8 pups/nest). At 40 and 80 days of age the postnatally overfed pups from SL nests became heavier, displayed a significantly increased epididymal plus retroperitoneal fat pad weight (P<0.01) and significantly higher AP activity in both segments of the small intestine (P<0.01) in comparison with rats nursed in NL nests, although their mean daily food intake did not differ from that of non-obese rats during the postweaning periods examined. In contrast, the same treatment of MSG rats had only a small effect on late appearance of obesity, i.e. in early postnatally overfed and normally fed MSG rats a similar pattern of body weight, food intake, adiposity and AP activity was found after weaning. The effect of MSG-treatment was also accompanied by the appearance of normophagia, hypophagia and stunted growth on day 40 and day 80, respectively. Moreover, the size of fat depots and the increase of brush-border-bound AP activity in MSG rats belonging to the SL and NL groups was quantitatively similar to the values size of these parameters observed in SL obese rats subjected to early postnatal overnutrition. These results indicate that postnatal nutritional experience (overnutrition) may represent a predisposing factor in control rats from small litters for the development of obesity in later life. Permanently increased small intestinal AP activity observed after weaning in both models of obesity when hyperphagia is not present suggest that these functional changes and associated alterations in food digestion could be a component of regulatory mechanisms contributing to the maintenance of their elevated body fat weight.
Effects of anesthesia and nociceptive stimulation on an experimental model of brachial plexus avulsion
Authors: Vaculín Š , Rokyta R
Published: November 2022

Unilateral dorsal rhizotomy of brachial plexus nerves (C5-Th1) performed under general anesthesia is known to induce self-mutilation in rats. The aim of this study was to determine the effect of different anesthetic agents, and of pre-rhizotomy nociceptive stimulation on the appearance of self-mutilation. Self-mutialtion appeared in 78 % of animals after rhizotomy had been performed under pentobarbital anesthesia. When ketamine was used as the general anesthetic, self-mutilation was almost suppressed (13 %) and consisted of superficial erosions. Mechanical nociceptive stimulation, when applied just before the induction of ketamine anesthesia and subsequent rhizotomy, provoked self-mutilation in 91 % of rats. Furthermore, a serious type of self-mutilation consisting of total amputation of the distal part of the forepaw was present in 28 % of all self-mutilating animals after previous nociceptive stimulation. In terms of self-mutilation, these results suggest 1) the crucial role of anesthesia, especially that which involved NMDA receptors (ketamine), and 2) the need of an additional factor to chronic deafferentation, formed either by activity of nociceptive pathways just before rhizotomy (nociceptive stimulation preceding ketamine anesthesia) or by injury discharges (pentobarbital anesthesia).
Effects of body mass index on maximal work production capacity and aerobic fitness during incremental exercise test.
Authors: Ozcelik O , Aslan M , Ayar A , Kelestimur H
Published: November 2022

The aim of this study was to investigate the relationship between cardiopulmonary fitness as indicated by maximal work rate (Wmax) production and aerobic capacities (WAT), body mass index (BMI) and heart rate reserve. A total of 60 sedentary subjects (30 males, 30 females, aged 18-25 years) were enrolled in the study. Each subject performed an incremental exercise test (15 W/min) to the limit of tolerance on an electromagnetically-braked cycle ergometer. There was a negative correlation between increased BMI to Wmax capacity per kilogram body weight in male (r=-0.846, P=0.0001) and in female (r=-0.896, P=0.0001) subjects. In addition, W(AT) for each kilogram body weight also negatively correlated with increased BMI in male (r=-0.870, P=0.0001) and in females (r=-0.807, P=0.0001). The heart rate reserve correlated negatively with increasing BMI: r=-0.699, P=0.0001 (males) and r=-0.655, P=0.0001 (females). The results of the present study have suggested that, due to the inverse correlation between BMI, Wmax capacity, aerobic fitness and heart rate reserve, it may be useful to consider BMI in establishing cardiopulmonary fitness in various subjects.
Hiding in Plain Sight: Intersectional Violence and Postfeminism in Chanson douce (2016) by Leïla Slimani
Authors: Cooper Jasmine
Published: November 2022

The first Moroccan woman to win the prestigious Prix Goncourt (in 2016, for Chanson douce), Leïla Slimani is the darling of the French literary world, a poster-girl of Macron’s France. But she is also accused of being a collabeurette, of pandering to white audiences and sensibilities. Chanson douce reveals the true cost of bobo (bourgeois-bohemian) life amongst the metropolitan elite. Exploring the pressures of gendered labour, compounded by economic and social stratification, Slimani holds up a mirror to French society, directly challenging any postfeminist claim that gender equality has been achieved. However, whilst racial – or at least linguistic, national and religious – difference is visible in the text, its presentation is dubious. In this article, I argue that postfeminist logic converges with the colour-blind universalism of France. I suggest that Slimani subsumes discussions of racial difference into a polemic which privileges gender and class inequalities, ultimately seeing her capitulate to French Republican values.
Sex Workers, Thinkers and Activists in France Today: A ‘Real’ Feminist Vanguard
Authors: Galis Polly
Published: November 2022

This paper explores three manifestoes by contemporary French sex workers, which combine personal memoir with theoretical and political writing: Libérez le féminisme by Morgane Merteuil (2012), Fières d’être putes by Maîtresse Nikita and Thierry Schaffauser (2007), and Porno manifesto by Ovidie (2002). I examine the complaints and demands they make of French feminists today, who frequently impede rather than support the aims of sex workers. I then outline these authors’ vision for a future feminism which could incorporate and learn from sex workers’ thought and activism, and which would be properly inclusive and radical. For these reasons, we will see why this envisaged feminism is deemed a ‘real’ feminism by some, to signify a surpassing or enhancement of earlier feminisms. Connections with a variety of feminisms will be considered, including postfeminism, sex positive feminism, and feminism in its second and fourth waves.
Multidrug Resistant Staphylococcus aureus Isolated from UTI Site and its Biofilm Inhibition Activity with Nanomaterials in Reference with Standard Antibiotics
Authors: Raja M. Mohamed Mahroop , M. Raja , Begum A. Fasila
Published: November 2022

Drug-resistant Staphylococcus aureus is a leading cause of nosocomial urinary tract infections and biofilm-associated illnesses worldwide. The present investigation intended to detect biofilm-forming Staphylococcus aureus, their antibiotic resistance, and plasmid profile. Thirty clinical urine samples were collected and tested for pathogen, drug-resistance pattern, plasmids profile, biofilm development, and molecular characterisation. Four strains of Staphylococcus aureus were discovered, according to Bergey's handbook. Kirby-Bauer technique was used to test antibiotic sensitivity and resistance. Four multidrug-resistant Staphylococcus aureus plasmids were examined by alkaline lysis. Among the four isolates, plasmid band was assigned, and additional investigations were employed for biofilm activity against four nanocomposite MoSe2, Mn3O4, Nb2O5 and ZnO-SnO2. Nanocomposite Nb2O5 inhibited biofilm at lower concentrations than cefotaxime. DNA was extracted and PCR was performed using the 16S rRNA gene for Staphylococcus aureus. Isolate phylogeny was analysed using Neighbor joining and uploaded to GenBank with accession number MG263510. Staphylococcus aureus multidrug resistance and biofilm formation are major medical challenges. Despite rising biofilm development rates, it is hard to compare, and hospitals have implemented tight infection control procedures. This study indicated that nanomaterials may help manage biofilmrelated illnesses
Impact of Yoga on Specific Risk Factors in Middle-Aged Women with Hypertension
Authors: D. Brindha , P. Arunachalam , R Elangovan
Published: November 2022

This randomised controlled trial set intended to examine the results of yoga practises on Systolic BP and Total Cholesterol in hypertensive middle-aged women. Thirty middle-aged hypertensive women from the city of Chennai were recruited at random using a random group sample approach and were divided into two groups of 15 patients each (Experimental group and Control group). The hypothesis was that middle-aged hypertensive women's Systolic Blood Pressure and Total Cholesterol would differ significantly from those of the Control group as a result of their yoga practises. Prior to the start of training, a preliminary test was performed on a chosen dependent variable. The yoga practises of the experimental group lasted for 12 weeks, with each session lasting no more than an hour each morning. The control group was required to maintain a state of mild activity. After the training period ended, both groups were given a post test measuring the same dependent variables, including systolic blood pressure and total cholesterol. Analysis of Co-Variance (ANCOVA) was used to statistically compare the data from= each group. A 5% level of significance was chosen for the test. The study found that the Experimental group's yoga practises led to statistically significant improvements in comparison to the Control group in terms of some variables including Systolic Blood Pressure and Total Cholesterol. Therefore, the hypothesis was accepted with a 0.05 level of confidence. Therefore, it can be inferred that yoga activities help middle-aged hypertensive women keep their Systolic Blood Pressure in check and their Total Cholesterol levels low
Juegos tradicionales en el desarrollo motor fino
Authors:   Universidad de las Fuerzas Armadas de Ecuador, Nacimba Taco Katerin Priscila , Tapia Reinoso Silvia Del Rocío ,   Universidad de las Fuerzas Armadas de Ecuador
Published: November 2022

El artículo es una revisión de publicaciones de los juegos tradicionales (transmisión de contenido social-cultural de la población) para comparar y realizar un análisis de lo que aportan los autores dentro del desarrollo motor fino durante la infancia, el mismo, que como conocemos, tiene su mayor desarrollo hacia el año y seis meses aproximadamente, siendo necesario promover su estimulación en los siguientes años. Desde la perspectiva pedagógica, se describen los juegos tradicionales por su origen, características, beneficios y su interacción con el área motora fina. Para ello, se realizó un estudio de revisión bibliográfica, en fuentes de revistas indexadas obteniendo 10 resultados, redirigiendo la búsqueda a fuentes secundarias. Las bases de datos académicos revisadas fueron: Google Académico, Dial net, Scielo y Redalyc. Los datos fueron analizados de manera cualitativa, focalizando sobre la importancia de los juegos tradicionales en el desarrollo motor fino. Los resultados indican un déficit teórico de investigación en cuanto a la importancia de los juegos tradicionales en el desarrollo motor fino. La práctica de los juegos tradicionales promueve el desarrollo motor fino y permiten la transmisión de los contenidos socio-culturales dentro de nuestra población. Algunos de estos juegos se propondrán a continuación.
Bioprinting for bone tissue engineering
Authors: Kang Xin , Zhang Xiao-Bo , Gao Xi-Dan , Hao Ding-Jun , Li Tao , Xu Zheng-Wei
Published: November 2022

The shape transformation characteristics of four-dimensional (4D)-printed bone structures can meet the individual bone regeneration needs, while their structure can be programmed to cross-link or reassemble by stimulating responsive materials. At the same time, it can be used to design vascularized bone structures that help establish a bionic microenvironment, thus influencing cellular behavior and enhancing stem cell differentiation in the postprinting phase. These developments significantly improve conventional three-dimensional (3D)-printed bone structures with enhanced functional adaptability, providing theoretical support to fabricate bone structures to adapt to defective areas dynamically. The printing inks used are stimulus-responsive materials that enable spatiotemporal distribution, maintenance of bioactivity and cellular release for bone, vascular and neural tissue regeneration. This paper discusses the limitations of current bone defect therapies, 4D printing materials used to stimulate bone tissue engineering (e.g., hydrogels), the printing process, the printing classification and their value for clinical applications. We focus on summarizing the technical challenges faced to provide novel therapeutic implications for bone defect repair.
mRNA therapy for myocardial infarction: A review of targets and delivery vehicles
Authors: Wang Xinming , Wu Douglas H. , Senyo Samuel E.
Published: November 2022

Cardiovascular diseases are the leading cause of death in the world. This is partly due to the low regenerative capacity of adult hearts. mRNA therapy is a promising approach under development for cardiac diseases. In mRNA therapy, expression of the target protein is modulated by delivering synthetic mRNA. mRNA therapy benefits cardiac regeneration by increasing cardiomyocyte proliferation, reducing fibrosis, and promoting angiogenesis. Because mRNA is translated in the cytoplasm, the delivery efficiency of mRNA into the cytoplasm and nucleus significantly affects its therapeutic efficacy. To improve delivery efficiency, non-viral vehicles such as lipid nanoparticles have been developed. Non-viral vehicles can protect mRNA from enzymatic degradation and facilitate the cellular internalization of mRNA. In addition to non-viral vehicles, viral vectors have been designed to deliver mRNA templates into cardiac cells. This article reviews lipid nanoparticles, polymer nanoparticles, and viral vectors that have been utilized to deliver mRNA into the heart. Because of the growing interest in lipid nanoparticles, recent advances in lipid nanoparticles designed for cardiac mRNA delivery are discussed. Besides, potential targets of mRNA therapy for myocardial infarction are discussed. Gene therapies that have been investigated in patients with cardiac diseases are analyzed. Reviewing mRNA therapy from a clinically relevant perspective can reveal needs for future investigations.
Comprehensive personalized ankle joint shape analysis of children with cerebral palsy from pediatric MRI
Authors: Cheng Yue , Bailly Rodolphe , Scavinner-Dorval Claire , Fouquet Benjamin , Borotikar Bhushan , Ben Salem Douraied , Brochard Sylvain , Rousseau François
Published: November 2022

Cerebral palsy, a common physical disability in childhood, often causes abnormal patterns of movement and posture. To better understand the pathology and improve rehabilitation of patients, a comprehensive bone shape analysis approach is proposed in this article. First, a group analysis is performed on a clinical MRI dataset using two state-of-the-art shape analysis methods: ShapeWorks and a voxel-based method relying on Advanced Normalization Tools (ANTs) registration. Second, an analysis of three bones of the ankle is done to provide a complete view of the ankle joint. Third, a bone shape analysis is carried out at subject level to highlight variability patterns for personnalized understanding of deformities.
Fibroblast growth factor 2 is a druggable target against glioblastoma: A computational investigation
Authors: Siddique Rabeea , Abideen Syed Ainul , Nabi Ghulam , Awan Faryal Mehwish , Noor Khan Sadiq , Ullah Fawad , Khan Suliman , Xue Mengzhou
Published: November 2022

Fibroblast growth factor 2 (FGF2) is a key player in cancer and tissue homeostasis and regulates renewal of several stem cell types. The FGF2 role in malignant glioma is proven and tagged FGF2, a novel druggable target, is used for developing potent drugs against glioblastoma. In this study, Asinex 51412372, Asinex 51217461, and Asinex 51216586 were filtered to show the best binding affinity for FGF2 with binding energy scores of −8.3 kcal/mol, −8.2 kcal/mol, and −7.8 kcal/mol, respectively. The compounds showed chemical interactions with several vital residues of FGF2 along the compound length. The noticeable residues that interacted with the compounds were Arg15, Asp23, Arg63, and Gln105. In dynamic investigation in solution, the FGF2 reported unstable dynamics in the first 100 ns and gained structural equilibrium in the second phase of 100 ns. The maximum root mean square deviation (RMSD) value touched by the systems is 3 Å. Similarly, the residue flexibility of FGF2 in the presence of compounds was within a stable range and is compact along the simulation time length. The compounds showed robust atomic-level stable energies with FGF2, which are dominated by both van der Waals and electrostatic interactions. The net binding energy of systems varies between −40 kcal/mol and −86 kcal/mol, suggesting the formation of strong intermolecular docked complexes. The drug-likeness and pharmacokinetic properties also pointed toward good structures that are not toxic, have high gastric absorption, showed good distribution, and readily excreted from the body. In summary, the predicted compounds in this study might be ideal hits that might be further optimized for structure and activity during experimental studies.
Advances in small molecule two-photon fluorescent trackers for lipid droplets in live sample imaging
Authors: Lee Dong Joon , Kim Eun Seo , Lee Hyo Won , Kim Hwan Myung
Published: November 2022

Two-photon fluorescent trackers for monitoring of lipid droplets (LDs) would be highly effective for illustrating the critical roles of LDs in live cells or tissues. Although a number of one-photon fluorescent trackers for labeling LDs have been developed, their usability remains constrained in live sample imaging due to photo damage, shallow imaging depth, and auto-fluorescence. Recently, some two-photon fluorescent trackers for LDs have been developed to overcome these limitations. In this mini-review article, the advances in two-photon fluorescent trackers for monitoring of LDs are summarized. We summarize the chemical structures, two-photon properties, live sample imaging, and biomedical applications of the most recent representative two-photon fluorescent trackers for LDs. Additionally, the current challenges and future research trends for the two-photon fluorescent trackers of LDs are discussed.
Pyrazolyl-s-triazine with indole motif as a novel of epidermal growth factor receptor/cyclin-dependent kinase 2 dual inhibitors
Authors: Shawish Ihab , Nafie Mohamed S. , Barakat Assem , Aldalbahi Ali , Al-Rasheed Hessa H. , Ali M. , Alshaer Walhan , Al Zoubi Mazhar , Al Ayoubi Samha , De la Torre Beatriz G. , Albericio Fernando , El-Faham Ayman
Published: November 2022

A series of pyrazolyl-s-triazine compounds with an indole motif was designed, synthesized, and evaluated for anticancer activity targeting dual EGFR and CDK-2 inhibitors. The compounds were tested for cytotoxicity using the MTT assay. Compounds 3h, 3i, and 3j showed promising cytotoxic activity against two cancer cell lines, namely A549, MCF-7, and HDFs (non-cancerous human dermal fibroblasts). Compound 3j was the most active candidate against A549, with an IC50 of 2.32 ± 0.21 μM. Compounds 3h and 3i were found to be the most active hybrids against MCF-7 and HDFs, with an IC50 of 2.66 ± 0.26 μM and 3.78 ± 0.55 μM, respectively. Interestingly, 3i showed potent EGFR inhibition, with an IC50 of 34.1 nM compared to Erlotinib (IC50 = 67.3 nM). At 10 μM, this candidate caused 93.6% and 91.4% of EGFR and CDK-2 inhibition, respectively. Furthermore, 3i enhanced total lung cancer cell apoptosis 71.6-fold (43.7% compared to 0.61% for the control). Given the potent cytotoxicity exerted by 3i through apoptosis-mediated activity, this compound emerges as a promising target-oriented anticancer agent.
PfHMGB2 has a role in malaria parasite mosquito infection
Authors: Kumar Sudhir , Kappe Stefan H. I.
Published: November 2022

Differentiation of asexually replicating parasites into gametocytes is critical for successful completion of the sexual phase of the malaria parasite life cycle. Gametes generated from gametocytes fuse to form a zygote which differentiates into ookinetes and oocysts. The sporozoites are formed inside oocysts which migrate to the salivary glands for next cycle of human infection. These morphologically and functionally distinct stages require stage-specific gene expression via specific transcriptional regulators. The capacity of high mobility group box (HMGB) proteins to interact with DNA in a sequence independent manner enables them to regulate higher order chromosome organization and regulation of gene expression. Plasmodium falciparum HMGB2 (PfHMGB2) shows a typical L- shaped predicted structure which is similar to mammalian HMG box proteins and shows very high protein sequence similarity to PyHMGB2 and PbHMGB2. Functional characterization of PfHMGB2 by gene deletion (Pfhmgb2¯) showed that knockout parasites develop normally as asexual stages and undergo gametocytogenesis. Transmission experiments revealed that Pfhmgb2¯ can infect mosquitoes and develop as oocyst stages. However, transmission was reduced compared to wild type (WT) parasites and as a consequence, the salivary gland sporozoites were reduced in number. In summary, we demonstrate that PfHMGB2 has no role in asexual growth and a modest role in sexual phase development and parasite transmission to the mosquito.