bluuebunny/crossref_metadata_2025 huggingface dataset:
Soviet Politics and Diplomacy in the Far East: Strategies and Alliances on the Eve of and During World War II
Authors: Dubinin Yu. A.
Published: January 2024

This article offers an in-depth analysis of Soviet policy and diplomacy in the Far East during the tumultuous period spanning from the 1920s to the 1940s. These policies were profoundly shaped by two key factors: firstly, the ideological considerations rooted in the political framework established in the USSR following the 1917 revolution, and secondly, the geopolitical dynamics reflecting the evolving global and regional political landscape in the Far East. The ruling Bolshevik Party and the Soviet government faced formidable challenges as they sought to safeguard the nascent Soviet Republic amid mounting international tensions, both on a global scale and within the Asia-Pacific region.This study aspires to present a comprehensive and integrated examination of Soviet policy and diplomacy during this era. It delineates four distinct chronological segments, each characterized by its unique features, priorities, and challenges. At the same time, these segments are united by the overarching goal of consolidating the Soviet Union's position in the Far Eastern region and the broader Pacific theater. The four discernible stages in Soviet policy and diplomacy in the Far East encompass:1.    The period spanning from 1927 to 1932, marked by an initial deterioration in relations between the Soviet government and the Kuomintang administration following the 1927 split between the Kuomintang and the Communist Party of China (CPC). This phase also witnessed the 1929 conflict on the Chinese Eastern Railway and culminated in the reestablishment of Sino-Soviet relations, all set against the backdrop of escalating Japanese aggression in Northeastern China (Manchuria). This phase demanded adroit diplomacy balancing strength and strategic statecraft.2.    The 1930s, especially in the aftermath of Japan's aggressive incursions into China, saw limited interaction and collaboration between the USSR and the Republic of China. This period featured cautious Soviet-Japanese relations and included significant events such as armed clashes at Lake Khasan and the Khalkhin-Gol River, as well as the signing of the USSR-Japan Neutrality Pact.3.    The era of the Great Patriotic War from 1941 to 1945, during which the Soviet Union's foremost objective was the defeat of the German Nazi aggressor. During this period, Soviet diplomacy was primarily preoccupied with relations with Anglo-American allies, with particular emphasis on the contentious issue of opening a second front. Consequently, Far Eastern and Pacific policy concerns assumed a somewhat marginalized role within the realm of Soviet diplomacy.4.    Finally, the period spanning from the winter to the summer of 1945 emerged as a pivotal juncture. During this time, the Soviet Union intensified its political, diplomatic, and military involvement in the Far East, all against the backdrop of preparations for the impending entry into the war against Japan. Diplomatic endeavors reached their zenith during this critical phase.
Förvaltningsarbete för mångfald och konkurrens
Authors: Irisdotter Aldenmyr Sara
Published: January 2024

This article reflects on the possibility to promote diversity in Swedish schools. Our municipal authorities are responsible of managing schools financially as well as promoting diversity and equality. Thus, several critical researchers claim that the marketization of the educational sphere, including students’ freedom of choice, leads to segregation and discrimination. There are also theorists who claim the opposite by pointing out that the free market represents democratic values and promotes diversity. The aim of this article is to study how administrators of the municipal authorities reflect on their possibility to promote diversity within a marketized school system. The material consists of four interviews with head administrators of municipal authorities. The results partly confirm the clash between competition, freedom of choice and diversity. Yet, the municipal administrators seem to believe in the possibility to further the progress of diversity within the marketized school.
HUBUNGAN ANTARA KOMUNIKASI TERAPEUTIK PERAWAT DENGAN KECEMASAN KELUARGA PASIEN YANG DIRAWAT DI RUANG ICU RSU BANGLI
Authors: Puspita Dewi Ni Kadek Santi , Kamayani Made Oka Ari , Sani Utami Putu Ayu , Sulistiowati Ni Made Dian
Published: January 2024

Intensive Care Unit (ICU) is a form of service in hospitals in the critical care category. Communication is a basic skill needed by a nurse, but is often not carried out effectively, causing anxiety in the family. The aim of this research was to determine the relationship between nurses' therapeutic communication and the anxiety of families of patients treated in the ICU at RSU Bangli. This research used a quantitative research method with a correlative descriptive design with a cross sectional approach on 30 respondents selected based on inclusion and exclusion criteria. Data analysis used the Spearman rank correlation test and the research results obtained a significance value of p value = 0,393 (>0,05) so there was no significant relationship between nurses' therapeutic communication and family anxiety of patients treated in the ICU at RSU Bangli. Good communication in murder is very important because without communication murder services are difficult to implement. Nurses who use interactive communication techniques will create a better perception of achieving good health conditions and the patient's family will feel they understand the health condition of their family members. This will result in a state of anxiety felt by the patient's family. Nurses can also help identify the anxiety conditions felt by the family and can provide information and interventions that can reduce or minimize the anxiety experienced by the patient's family.
HUBUNGAN ANTARA SIKAP KERJA DENGAN KELUHAN LOW BACK PAIN PADA PENGRAJIN GAMELAN DI DESA TIHINGAN
Authors: Purnama Pande Made Dwi Ayu , Nurhesti Putu Oka Yuli , Manangkot Meril Valentine
Published: January 2024

Low back pain is a part of musculoskeletal disorders that often occur during work activities. Low back pain complaints are experienced among public and mostly occur among workers such as gamelan craftsman. The process of making gamelan through several stages causes pain that is felt in the body. One factor that influences the onset of pain is work attitude. Non-Ergonomic work attitude will increase the risk of low back pain among workers. This study aimed to determine the correlation between work attitude and low back pain complaints among gamelan craftsmen. This study was a correlative descriptive study. Total sampling was used to recruit 57 respondents. Work attitudes and low back pain complaints are measured using Nordic Body Map (NBM) and REBA questionnaires. Data analysis that used was the Spearman rank test. The result shows that there is a significant and strong correlation with positive direction between work attitudes and low back pain complaints among gamelan craftsmen with p-value < 0,0001, r = 0,653. The result also show that determinant coefficient is 42,6%, it means work attitude has a correlation with low back pain complaints among gamelan craftsmen by 42,6%, Thus, the gamelan craftworkers require to adjust with body position and control the work duration to escape from health risk, such as low back pain.
HUBUNGAN DUKUNGAN KELUARGA DAN TENAGA KESEHATAN DENGAN MOTIVASI KESEDIAAN MASYARAKAT MENERIMA VAKSIN COVID-19 DI DESA ANGGRASMANIS KABUPATEN KARANGANYAR
Authors: Taen Cindy Valla , Sari Dian Nur Adkhana , Suryati Suryati , Setyaningrum Niken
Published: January 2024

2019 was shocked by the outbreak of a new virus, namely Covid-19. One possible strategy to stop the spread of this virus is to produce a vaccine. Vaccines are the last line of defense against infectious diseases. The main obstacle to using the Covid-19 vaccine is people's disbelief in preventing Covid-19 vaccination. The desire to get the Covid-19 vaccine is influenced by several things including family support and support from health workers. With the motive of community readiness to get the Covid-19 vaccination, this study seeks to find out the relationship between family support and health workers in Anggramanis village, Kecamatan Jenawi Kabupaten Karanganyar. This type of research is quantitative, the sample size is 290 respondents and the sampling technique is accidental sampling. Data collection was carried out from May 27 to June 10, 2022. Data testing used the chi square analysis test and multiple linear regression. This study used three research instruments, namely the family support questionnaire, the health worker support questionnaire, and the motivational questionnaire on the willingness to accept the Covid-19 vaccine. The results of the chi square test obtained a value of p = 0,000 and a contingency value of 0,406 (family support) and 0,349 (support of health workers). Thus there is a relationship between family support and health workers with the motivation of the community's willingness to receive the Covid-19 vaccine in Anggramanis Village Kecamatan Jenawi Kabupaten Karanganyar.
HUBUNGAN PERILAKU SELF-MANAGEMENT DENGAN KUALITAS HIDUP PENDERITA HIPERTENSI DI PUSKESMAS MADURAN LAMONGAN
Authors: Soliha Siti , Lestari Trijati Puspita , Maghfiroh Isni Lailatul
Published: January 2024

Increased blood pressure in people with hypertension will have an impact on decreasing quality of life. One of the efforts to prevent complications of hypertension is the application of self-management behavior. People with hypertension have good self-control if they are actively involved in caring behavior and making decisions that support their own health. The purpose of this study was to determine the relationship between self-management behavior and the quality of life of hypertensive patients at the Maduran Lamongan Health Center. This study used a cross-sectional approach to 88 hypertensive patientswho were recruited by consecutive sampling. Data were collected using a questionnaire on hypertension self-management behavior and the quality of life of hypertension sufferers and analyzed using the Spearman Rank test. The results showed that (89,8%) hypertensive patients had self-management behavior. The good one (87,5%) had a good quality of life. The results of the Spearman Rank test showed p = 0,000 (p < 0,05) and r = 0,914 which means that there is a significant relationship between self-management behavior and the quality of life of hypertensive patients with a very strong affinity. Hypertension sufferers who have good self-management behavior will have a high quality of life. Therefore, it is hoped that hypertension sufferers can improve self-management behavior by adopting a healthy lifestyle and routinely monitoring blood pressure at health facilities to achieve the desired quality of life want.
On the ways to improve the information content and analyzability of contemporary accounting forms
Authors: KUMEKHOV Konstantin K. , SOROKINA Larisa N. , BEKULOV Khabas M.
Published: January 2024

Subject. This article analyzes the processes and phenomena associated with the improvement of the informative and analytical nature of present-day forms of financial reporting.
Objectives. The article aims to identify the main factors that determine the architecture of accounting and reporting based on the assessment of experts, and develop measures to improve the informative and analytical content of accounting and reporting.
Methods. For the study, we used the general and specific scientific research methods, such as deduction and induction, synthesis and analysis, comparison, modeling, and observation.
Results. The article identifies the main factors and the degree of their influence on the architecture of the accounting and reporting system, which is most suitable for users. It offers the authors-developed measures to improve the level of analytical and informative accounting and reporting for internal and external users.
Conclusions. The system of accounting and reporting, the level of their informative value and analytics do not fully meet the needs of internal and external users, which leads to a decrease in the effectiveness of management decisions. In the development of accounting and reporting forms, the characteristics of the technologies related to the activities of the organization and the corresponding organizational structure should be taken into account as fundamental factors in the formation of an information system. Focus on IFRS and digital technologies in accounting cannot solve the problems of improving the information content and analytical nature of financial statements. Measures to improve the informative and analytical nature of modern forms of accounting reporting should be based on "economic thought".
Cytotoxic Lesion of the Corpus Callosum: A Case of Metabolic Disease in a New Mother
Authors: Fusco Francesca R , Bizzaglia Mirko , Luccichenti Giacomo
Published: January 2024

Cytotoxic lesions of the corpus callosum (CLOCCs) represent an array of different conditions involving the corpus callosum. CLOCCs do not demonstrate definite signs or symptoms of hemispheric disconnection, such as alien hand syndrome, pseudo-neglect, apraxia of the left hand, agraphia, alexia, and visual apraxia. In fact, symptoms are generally related to the primary cause of the cytotoxic lesion, such as pharmaceutical agents, malignancies, infections, metabolic disorders, trauma, and others.
COVID-19 e seus impactos na saúde mental e sintomas depressivos na população LGBTQIA+
Authors: Lima Maria Vitória Silva de , Rodrigues Matheus Duarte , Souza Sofia Oliveira de , Costa Gabrielly Galindo Azevedo , Alexandre Milena Ferreira de França , Melo Sillas Duarte de , Telles Lisieux Elaine de Borba , Valença Alexandre Martins , Silva Antônio Geraldo da
Published: January 2024

Introdução: Quando comparados a indivíduos cis-heterossexuais, a população LGBTQIA+ demonstra maior nível de sofrimento psíquico devido ao seu status de minoria. Acredita-se que sintomas depressivos, inclusive, podem ter sido exacerbados pelo isolamento social durante a pandemia de COVID-19, em parte pela perda de vínculos com seus pares e pela intensificação de conflitos familiares. Objetivo: Investigar a ocorrência de sintomatologia depressiva entre a população LGBTQIA+ durante o período de isolamento social na pandemia de COVID-19. Métodos: Trata-se de um estudo observacional com indivíduos LGBTQIA+, maiores de 18 anos, a partir de um questionário aplicado de forma remota, por meio do Google Forms, e presencialmente, no ambulatório de Psiquiatria do Hospital Universitário Oswaldo Cruz (HUOC), entre julho de 2021 e agosto de 2022. Além de variáveis sociodemográficas e tipo Likert, foi aplicada a escala de Beck para depressão (BDI). Resultados: Participaram da pesquisa 253 indivíduos. As respostas à BDI revelaram que 28,1% destes demonstraram depressão leve (10-18 pontos), 23,7% moderada (19-29 pontos) e 20,9% severa (acima de 30 pontos). Observou-se que a frequência de conflitos familiares relacionados à orientação sexual/identidade de gênero dos participantes, durante a pandemia de COVID-19, correlacionou-se significativamente com a ocorrência de sintomas depressivos (p = 0,001). Conclusão: Para profissionais de saúde mental, é imperativo considerar as vitimizações associadas à condição de minoria sexual e de gênero a fim de promover intervenções mais humanizadas para a população LGBTQIA+ após a pandemia de COVID-19.
Evaluation of Color Stability for Two Types of Denture Base Materials: Heat Cured Acrylic and Flexible Resin.
Authors: Shehab Ahmad Areej , Talib Bandar Khalid , Ezat Abd Al-majeed Alaa
Published: January 2024

Commonly consumed beverages used by human being daily (Tea & Cola) caused external staining. This study is done to evaluate the color stability for two different types of denture base materials against this external staining caused by (Tea & Cola). Sixty (60) samples were prepared, divided into two groups, 30 samples of heat cure acrylic material & 30 samples of flexible resin material (Valplast). Each group divided into three subgroups 10 samples in each, according to the type of staining solution that immersed in it, (synthetic saliva & tea), (synthetic saliva & Cola), and (synthetic saliva alone as a control). Tea & Cola were mixed with synthetic saliva in order to create intraoral environment to certain extent. Color measurement was made at Baghdad University, Collage of Engineering, using reflected spectrophotometer before immersion (at baseline) & after immersion, at intervals of (24 hours) & (1 week) respectively. The result was a highly significant difference between, heat cure acrylic & flexible resin a t baseline & the (flexible samples) were the higher value in discol oration than (heat cure acrylic samples) regardless the type of s taining solution. Maximum discoloration was seen in (synthetic sal iva & tea) solution for both denture base materials. Followed by (synthetic saliva & Cola) & (synthetic saliva alone) respectively . Both denture base mater ials had a color changes after immersion in staining solution (tea , Cola & synthetic saliva). The color changes, for two materi als, were increased with the increase of immersion time.
Anti-crisis tools in the system of public finance, taxation and management
Authors: Borovikova Elena Vladimirovna
Published: January 2024

Anti-crisis management is a set of techniques, methods, and tools for influencing crisis phenomena, the scale of which may be limited to the microlevel or cover industries, regions, and the economy as a whole. The author formulated a comprehensive goal of assessing the tools used by the state, clarifying theoretical and methodological provisions on the classification of anti-crisis measures, their correlation with the stages of the crisis, combining the anti-crisis concept with other approaches. The subject of the study is the anti-crisis tools of public administration, structured according to the directions of economic policy measures and financial regulation. The object of the study is a system of public administration aimed at adapting special tools in times of crises and negative external influences. The author obtained the following results: separate theoretical and methodological provisions regarding the tools are substantiated and other structural elements of the state anti-crisis management; identified the most popular from the point of view of developing practice and public policy impact measures having a financial, organizational, managerial and tax character; developed an approach to the classification of anti-crisis measures depending on the ways of impact on the economy and structuring anti-crisis management tactics and strategy of the post-crisis period; formulated proposals for development educational field and scientific directions in solving the tasks of personnel training of specialists in the field of crisis management.
Failures in the “Laboratories of Democracy” and Democratic Due Process as Constitutional Guardrails
Authors: Clifford Matthew C. , Bland F. Paul
Published: January 2024

In Dobbs v. Jackson Women’s Health Organization, the Supreme Court reversed decades of precedent supporting a substantive due process right to abortion under the Fourteenth Amendment, and purported to return the question of reproductive autonomy to the “democratic process” in the states. Justice Thomas, writing in concurrence, militated for reconsidering all of the Court’s substantive due process precedents. In today’s era of democratic backsliding, these are dangerous pronouncements with grave, if not existential, implications for democracy in the United States. The Dobbs majority hazardously asserted that state-level abortion legislation would, in fact, be the result of a democratic process. Further, because the law of democracy draws extensively from substantive due process, including where the Fourteenth Amendment “incorporates” textually enumerated constitutional rights against the states, the broader threat to substantive due process in the Dobbs majority opinion and Justice Thomas’s concurrence is also a direct threat to democracy itself.

Although the literature on democracy and the literature on substantive due process are both individually voluminous, there is surprisingly limited scholarship focused specifically on both as interrelated topics. Building from democratic theory and John Hart Ely’s political process theory of judicial review, this Article seeks to begin elaborating on the important connections between democracy and substantive due process that help explain the legal and practical importance of each to the other. In doing so, it also attempts to lay the groundwork for an approach to substantive due process rooted in the Federal Constitution’s vision of democratic self-government for a diverse society
Anisotropic Gold Nanoparticles Synthesized using Litchi chinensis Leaf Extract and their Effect on Breast Cancer
Authors: Kaur Ramanjeet , Singh Jitender , Avti Pramod K , Kumar Vivek , Kumar Rajesh
Published: January 2024

For its medicinal potential, especially in cancer therapy, eco-friendly gold nanoparticles (GNPs) have gained a lot of interest. This investigation used Litchi chinensis leaf extract (LLE) as a reducing agent for the one-step synthesis of regulated-size GNPs. Fourier transform infrared (FTIR) spectrum shows that the bio-molecules act as capping and reducing agents. The formation of GNPs has been confirmed using UV-vis absorption spectra. Effect of various synthesized parameters, i.e., reaction time (5–120 minutes), temperature (25–100°C), solvent quantity (5–45 μL), metal ion concentration (0.25–2 mM) and pH (2–10) has been studied. The size, distribution, and morphology (anisotropic) have been studied using field emission scanning electron microscopy (FESEM) and dynamic light scattering (DLS) techniques in the range of 10 to 70 nm. X-Ray diffraction (XRD) reveals that the particles were crystalline and had face-centered cubic (FCC) structure, and transmission electron microscopy (TEM) images revealed anisotropic morphology (spherical, hexagonal, and triangular). In-vitro studies of GNPs on breast cancer cell lines show cytotoxicity with cellular structural alterations and caused DNA damage without the micronuclei formation.
Catechins as Catalase Modulators: A Comprehensive In-silico Analysis Unveiling their Potential Antioxidant Effects
Authors: Tare Harshal , Thube Ujjwala , Kachave Ramanlal , Wagh Vijay , Udugade Babaso
Published: January 2024

This research explores the potential of carefully selected catechins as catalase modulators, leveraging their documented antioxidant effects. The catalase protein’s structural quality was rigorously evaluated, revealing an overall high-quality 3D structure. Ligand-based virtual screening identified ten novel catechin hits with promising interactions, presenting candidates designed for new validation. Molecular docking simulations demonstrated robust binding empathies between selected catechins and catalase, with CHEMBL223855 exhibiting the highest affinity. ADMET analysis highlighted CHEMBL223855 as a promising candidate for drug development, boasting favorable properties, including high gastrointestinal absorption and absence of blood-brain barrier permeation. Despite medicinal chemistry alerts and lead likeness violations, this comprehensive analysis guides future experimental validation efforts, supporting the potential of these catechins as effective catalase modulators.
Eriodictyol Flavanones Based Virtual Screening of Bioactive Compounds from ChEMBL 2D Database with Classic 3-point Pharmacophore Screening Method for HER2 Inhibitors for Breast Cancer
Authors: Tare Harshal , Bedse Anjali , Thube Ujjwala , Kachave Ramanlal , Wagh Vijay
Published: January 2024

Understanding binding interactions between flavanones and human epidermal growth factor receptor 2 (HER2) is an important step in developing effective treatments for breast cancer, and this study applies computational methods to do just that. This research presents a comprehensive computational methodology for identifying potential HER2 inhibitors with a focus on breast cancer treatment. The study leverages a combination of structural and pharmacophore-based approaches, starting with bioactive compound selection from the ChEMBL 2D database. The PDB-REDO refined crystal structure of Kinase domain of Human HER2 (erbB2) was used to conduct molecular docking simulations with the identified drugs. The Kleywegt-like plot analysis demonstrates the improved structural quality of the HER2 kinase domain after refinement, showing enhanced agreement with experimental data. Molecular docking simulations, conducted using the AutoDock tool, reveal the binding affinity and interaction patterns of selected compounds with the HER2 receptor. Virtual screening results highlight compounds with high binding affinity, favorable interaction patterns, and structural compatibility as potential lead candidates. To ensure safety and efficacy, ADMETox filtering was employed, providing insights into the compound’s toxicity profile and pharmacokinetic attributes. The selected compound, Eriodictyol (C20H20O6), exhibits a generally favorable safety profile, with predicted inactivity across multiple toxicity classifications and endpoints. While immunotoxicity is predicted, the overall low probabilities suggest a relatively low risk. Physicochemical and pharmacokinetic assessments indicate Eriodictyol’s potential for drug development. With a molecular weight of 356.37 g/mol, balanced lipophilicity, and high gastrointestinal absorption, the compound aligns with drug-likeness criteria. However, careful consideration is warranted due to its inhibitory effects on certain enzymes and alerts for catechol_A and isolated_alkene. In conclusion, this integrated computational approach streamlines the identification of potential HER2 inhibitors, offering a systematic strategy for drug discovery. Eriodictyol emerges as a promising candidate, demonstrating a favorable safety profile and pharmacokinetic attributes, paving the way for further in-depth studies and development as a potential therapeutic agent for breast cancer.
Repurposing FDA-Approved Anastrozole-based Drugs for Breast Cancer through Drug-Drug Transcriptomic Similarity and Cavity Detection Guided Blind Docking
Authors: Mujawar Tabjez , Tare Harshal , Deshmukh Nitin , Udugade Babaso , Thube Ujjwala
Published: January 2024

Breast cancer remains a significant global health concern, necessitating innovative strategies for drug discovery and development. Repurposing existing drugs offers a promising avenue, leveraging the wealth of information available on food and drug administration (FDA) approved compounds. This study investigates the repurposing potential of anastrozole-based drugs, already established for their efficacy in certain conditions, for breast cancer treatment. This research presents a multifaceted investigation into the identification, structural refinement, and virtual screening of potential therapeutics targeting the aromatase CYP19A enzyme, a crucial player in hormone-related conditions such as breast cancer. The study commences with the identification of anastrozole-based drugs exhibiting transcriptomic profiles closely resembling known breast cancer therapeutics. Through a comprehensive analysis, a subset of compounds demonstrates high transcriptomic similarity, suggesting shared molecular pathways and target interactions. Notably, anastrozole, a well-known aromatase inhibitor, emerges as a top candidate, highlighting its potential in breast cancer treatment. The crystallographic structure of aromatase CYP19A is subjected to meticulous preprocessing using the PDB-REDO server, resulting in significant improvements in various validation metrics. Structural changes, including alterations in rotamers, removal of water molecules, and peptide flips, indicate the success of the refinement process in enhancing the accuracy of the protein model. The refined structure serves as a reliable foundation for subsequent studies. Further, structure-based cavity detection unveils potential binding sites on the aromatase enzyme. Docking studies employing the cb-dock server elucidate the interaction patterns and binding affinities of selected compounds within these cavities. Anastrozole, along with other candidates like dolasetron and stiripentol, exhibits promising binding scores and interacts with specific residues crucial for enzyme activity. This integrative approach, combining transcriptomic similarity analysis, structural refinement, and virtual screening, provides valuable insights into potential lead compounds for the inhibition of aromatase in breast cancer therapy. The identified compounds offer a starting point for further experimental validation and drug development. The most promising compound that can be repurposed for as an aromatase inhibitor is dolasetron. Overall, this research contributes to the ongoing efforts to leverage computational methodologies for the rational design of targeted therapeutics against hormone-related disorders.
Ecotoxicological Effects of Lead Exposed Cyprinus carpio and HSP70-Induced Antioxidants against ROS
Authors: Mathew Sherin , P Sankarganesh , Joseph Baby
Published: January 2024

Lead (Pb) is one of the leading heavy metal pollutions in freshwater sources. This study summarises lead accumulation in freshwater fish Cyprus carpio and its toxicological effects. Pb is known to induce neuro, nephro, and hepatotoxicity in C. carpio and, finally, humans. The effect of Pb leads to the generation of reactive oxygen species (ROS) and antioxidants in the tissues of C. carpio. Antioxidant assays revealed the extent of free radical scavenging activity of the infected tissues. LC50 at a time interval of 24 hours showed a concentration of 7.919 ppm. ROS analysis revealed that the highest concentration of Pb toxicity was observed in the kidneys, liver, and brain of C. carpio. Not only free radicals but also Pb toxicity have been known to activate heat shock proteins as a result of oxidative stress management. This study has raised alarming responses to freshwater aquaculture to initiate control measures against the toxicity and prevent its further entry into the food chain.
Larvicidal Activity of Ethanol Extract of Cinnamomum sintoc Blume Bark against Aedes aegypti: Role of the Extract as an Acetylcholinesterase Enzyme Inhibitor
Authors: Hayatie Lisda , . Joharman , Wydiamala Erida , Halisha Shabrina N , Andamari Indica
Published: January 2024

The display ponders evaluated the larvicidal exercises of ethanol bark extricates of Cinnamomum sintoc BI against the third instar hatchlings of Aedes aegypti. For superior understanding, this show ponders moreover examined the instrument of plant extricates against the hatchlings through in silico examination. Larvicidal exercises of plant extricate were considered within the extent of 0.01 to 0.1% and two control bunch with aquades and temephos within the research facility bioassays against early third instar hatchlings of A. aegypti. The mortality was checked and subjected to probit investigation to decide the deadly concentrations (LC50 and LC90) to murder 50 and 90% of the treated hatchlings of the particular species. Also, to examine the instrument, four dynamic compounds within the plant extricate with the most noteworthy substance analyzed in silico with the acetylcholinesterase protein in A. aegypti. The appears about appear expanding the concentration will increment the passing of the hatchlings and the viability of the extricate is found to be superior to temephos. The comes about of in silico investigation appeared that the two dynamic compounds in plant extricates, specifically α-copaene and γ-muurolene have a component of activity comparable to temephos. Both of these compounds work as inhibitors of acetylcholinesterase chemicals. Our information recommends that the bark ethanol extricate of C. sintoc BI have the potential to be utilized as a larvicidal operator for the control of the A. aegypti.
Formulation, Characterization, Optimization, and In-vitro Evaluation of Rosuvastatin as Nanofiber
Authors: Mohammed Ihsan A , Al-Gawhari Fatima J
Published: January 2024

Bioavailability is the objective for an optimum formulation. The target of the analysis is to maximize both the fluidity and disintegration profile of class II weakly compounds that are water-soluble. Anti-dyslipidemia drug rosuvastatin calcium (RC) (bioavailability 20%) through formulating as nanofibers (NFs) using electrospinning (ES) technology. Twenty formulas were prepared, and different polymers and polymer combinations with various concentrations were used such as polyethylene oxide (PEO) polyvinyl pyrrolidine (PVPK-30), and hydroxypropyl methylcellulose (HPMC). Three distinct groups of maximum parameters, including polymeric solution, electrospinning method, and ambient parameter, are capable of influencing the creation along with the shape of those ultimate NFs. The prepared formulas of rosuvastatin calcium nanofibers (RC-NFs) were evaluated for nanofibers diameter, dissolution profiles, free standing microscopy with electrons and fourier transformation infrared (FTIR)spectroscopy are also available. As a consequence, the velocity of dissolution increases as the particle’s surrounding area increases because of the its small size decrease to the nano level. The optimum ES parameters of polymeric solution (polymer type, concentration, combination, and effect of solvent type), ES process (injection flow rate, voltage, needle gauge, collector round per minute, needle to collector distance and collector type) and ambient parameter are tested and determined. Results show that four selected formulas of NFs are (F12, F14, F15 and F19) with an average diameter of (95, 120, 100 and 80 nm) respectively. The best ultrafine, smooth and beadless NFs is (F19) determined the fact that the narrower the circumference of the RC-NFs, the quicker its breakdown and the shorter the period of this medicinal component’s liberation.
A Comparative Study of Influence of Different Polymers on Lumefantrine: Piperine Solid Dispersion
Authors: Khade Rajendra R , Butle S R
Published: January 2024

To improve the oral delivery of biopharmaceutical classification system (BCS) class II drugs, solid dispersions techniques are generally adopted in drug product develooment in pharmaceuticals. The choice of polymer in these designs significantly affects a drug’s solubility and dissolution properties. The crystalline nature and the involvement of P-glycoprotein in active ingredient efflux further hinder drug absorption and bioavailability. In this study, solid dispersion (SD) of an antimalarial drug (lumefantrine) combined with piperine (a P-gp and CYP3A4 inhibitor), was created using different polymeric carriers: Soluplus, Klucel, Poloxamer, Povidone/PVP K30 (PVP), and Copovidone/Kollidon® VA64 (KOL). Among these, LUMF-PIP solid dispersion with SOL exhibited the maximum water solvency and fastest release across various media. These findings indicate that the choice of polymeric carrier significantly impacts LUMF’s solubility and dissolution behavior in solid dispersion. SOL emerges as the most promising polymer for enhancing LUMF’s solubility and dissolution, ultimately leading to improved bioavailability upon oral administration.
Preparation, Characterization and In-vitro Evaluation of Nano Encapsulated 1-Octacosanol for Solubility Enhancing by using Various Polymers through Spray Drying Approach
Authors: Singh A K , Kharb R , Kandpal J B
Published: January 2024

This research aimed to develop a nano-encapsulated free-flow powder of 1-octacosanol for functional food application. We had prepared stable green nano-emulsion oil in water by Dyno Mill and spray dryer for free flow powder by using different polymers (Hydroxypropyl methylcellulose, polyvinylpyrrolidone, octenyl succinate starches) as hydrophilic polymers in different ratios for enhancing the solubility. Zeta potential, X-ray diffraction (XRD), fourier transform infrared spectroscopy (FTIR), encapsulation efficiency, particle size distribution, surface morphology, differential scanning calorimetry spectroscopy and in-vitro dissolution research were used to analyze 1-octacosanol. The optimized nano-emulsion preparation F15 consists of an average particle size 720.9 nm, zeta potential -24.5 mV shows stable nano-emulsion oil in water type, and encapsulation efficiency was found to be 96.76%, FTIR studies did not show any evidence of interaction between the herbal extract and the polymers. XRD shows the conversion of crystalline to amorphous nature of powder. In differential scanning calorimetry (DSC), spectroscopy studies found three major peaks in standard herbal extract peaks is 60.21, 67.16, 81.27°C and nano-encapsulated spray dried powder peaks are 58.18, 66.44, 79.25°C with minor moisture absorbed by the polymer in formulation. This evaluation shows significant improvement between normal herbal extract of 1-octacosanol and encapsulated spray-dried powder of 1-octacosanol for functional food application successfully improving the water solubility without changing a structural and chemical properties of the 1-octacosanol crystal.
Investigation of Antimicrobial Activity and Characterization of Isolated Allyl Isothiocyanate
Authors: Patil Prashant B , Goswami Hardik , Chaudhari Arjun , Patel Jayvadan K
Published: January 2024

Allyl isothiocyanate (AITC) is a natural compound known for its potential antimicrobial properties. In this study, we present a comprehensive investigation into the isolation, characterization, and antimicrobial activity of AITC which is obtained from mustard seeds. The isolation of AITC was achieved through an efficient extraction process, employing extraction assembly. Subsequently, AITC was subjected to a series of physicochemical tests to elucidate the presence of physicochemical constituents. Furthermore, we employed UV-visible spectroscopy and infrared (IR) spectroscopy to obtain valuable insights into the structural features of AITC. To gain a deeper understanding of the phyto-constituents present in AITC, gas chromatography-mass spectroscopy (GC-MS) was used for phytochemical profiling. The antimicrobial activity of AITC was assessed against two pathogenic microorganisms, Staphylococcus and Escherichia coli. The outcomes of our study reveal the possible potential of AITC as an antimicrobial agent, demonstrating its inhibitory effects on the growth of both microbial strains and zone diameter of inhibitions are 12, 10, and 4 mm for Staphylococcus and 14, 12 and 6 mm for E. coli and hence the AITC extracts were found to have antibacterial activity. This research provides treasured comprehensive insights into the isolation, characterization, and antimicrobial belonging properties of AITC which is derived from mustard seeds. The findings suggest that AITC has promising applications in the field of antimicrobial research, opening avenues for further investigation into its potential therapeutic uses.
Design and Discovery of Genistein-based Drugs as a Potential Tyrosine Kinase Inhibitor for Lung Adenocarcinoma through Hybrid In-silico Methods
Authors: Wakale Vijay , Kachave Ramanlal , Gholap Pranjal , Mahajan Kiran , Tare Harshal
Published: January 2024

This research employs a comprehensive approach to investigate potential therapeutic candidates for lung adenocarcinoma through drug-drug transcriptomic similarity analysis and molecular docking simulations. Using the Connectivity Map Touchstone tool, we identified compounds with high transcriptomic similarity to genistein, revealing potential shared mechanisms of action. The selected compounds, including avrainvillamide-analog-2, were further assessed through molecular docking simulations against the tyrosine kinase inhibitor (TKI) enzyme. Avrainvillamide-analog-2 exhibited a remarkable binding affinity in pocket C2, interacting with key amino acids. The results provide valuable insights into the pharmacological properties of the identified compounds, laying the groundwork for future experimental validations and drug development initiatives. Additionally, cavities detection by CB Dock server and structural refinement by PDB REDO contribute to the overall understanding of ligand binding and protein structure. This integrative approach offers a holistic perspective for identifying potential lead compounds and understanding their molecular interactions, facilitating the rational design of novel therapeutics for lung adenocarcinoma.
Preparation and Evaluation of PLGA-based Nanoparticles
Authors: Choudhary Ram K , Kumar Kandukuri A , Kommineni Srividya , Narkhede Minal , KommDevineniineni Jyothirmayee
Published: January 2024

The current study aimed to increase the stability and therapeutic efficacy of the antitubercular medication rifampicin by reducing or preventing its breakdown in the stomach pH state. Ascorbic acid was used as an antioxidant in the preparation of rifampicin-loaded Poly(lactic-co-glycolic acid) (PLGA) nanoparticles for the investigation. A multistep emulsion process was used to create dig-laden nanoparticles, and different techniques were then used to assess the final product. Ten different kinds of formulations were created for this study. According to the study’s findings, ascorbic acid can increase rifampicin’s stability and bioavailability by reducing its breakdown in acidic pH conditions. The results also show that changing the ascorbic acid concentration makes a statistically important difference in the way the medicine breaks down.
ON THE SOLVABILITY OF THE SCHR¨ODINGER EQUATION WITH POWER AND LOGARITHMIC-POWER TYPE OF NONLINEARITIES
Authors: P.POPIVANOV P.POPIVANOV , ANGELASLAVOVA ANGELASLAVOVA
Published: January 2024

ThispaperdealswiththenonlinearSchr¨ odingerequation(NSE)withpolynomial(powertype)andpowerlogarithmicnonlinearities.Athirdordergeneralizationof NSE-thesocalledRKLEwithapplications intelecommunications isconsideredtoo. In somespecial casesthesolitonsolutionsortheblowingupsolutionscanbeexpressedby elementaryorspecial functions(elliptic,hyperbolic).Weare lookingfor thewavesolutionsansatzhavingrealnon-negativeamplitudeandlinearphase.Theamplitudesatisfies secondordernonlinearODEandit isconstructedbyusingthemethodoffirst integral (inmechanicprocesseswithonedegreeof freedomaredescribedbysuchtypeODEs). Sothesolutionsarefoundintointegral formandone-parametricfamilyofperiodicsolutionsisconstructed. Several illustrativeexamplesofperiodic,blowingupandsolitontype solutionsareproposed.
DEVELOPMENT OF A PROBLEM BASED LEARNING E-MODULE WITH THE ASSISTANCE OF CANVA ON THE MATERY OF BALANCE AND ROTATIONAL DYNAMICS TO GROW STUDENTS' INTEREST IN LEARNING
Authors: Senja Bone Komala , Medriati Rosane , Putri Desy Hanisa
Published: January 2024

This study aims to determine the feasibility of developing the Problem Based Learning e-module  developed using canva to foster student interest in learning. This research method uses R&D research with the ADDIE type. The instruments used were observation, interviews and needs analysis questionnaires which obtained results of 81.04% with categories strongly agreeing to develop e-modules. The design of the e-module learning media will be developed according to what has been prepared. Expert validation sheet instruments consisting of aspects  of content feasibility, material presentation, language, media, PBL  and interest in learning can be seen that the development  of e-modules is very feasible with an average percentage of 88.54% and student   perception results which has 3 aspects, namely the appearance, presentation of material and benefits has an average yield of 81.81% of 3 Bengkulu City High Schools which can be categorized as very good. It can therefore be concluded that the development of the E-module Problem Based Learning assisted by Canva on the material of balance and rotational dynamics to foster students' interest in learning becomes a very viable product.
APPLICATION OF THE TEAM ASSISTED INDIVIDUALIZATION MODEL OF LEARNING IN INCREASING HIGH SCHOOL STUDENTS' LEARNING MOTIVATION
Authors: Suryani Suryani , Putri Desy Hanisa , Risdianto Eko
Published: January 2024

This research was conducted to determine the increase in learning motivation and student responses to the application of the Team Assisted Individualisation learning model on elasticity material. This type of research is a pre-experiment research with One-group pretest-posttest design. The research sample was taken with random sampling technique. The results of the data analysis of the learning motivation questionnaire after the application of the TAI learning model resulted in a very high category and an N-gain value of 0.45 which is in the medium category. This is evidenced by the results of the data analysis test using the t-test: Two-Sample Assuming Equal Variances with α = 0.05 assisted by Ms.Excel produces good results (P (T <=t)) 0.000 for one-tail and two-tail less than the value of α = 0.05. Based on the results of data analysis of student response questionnaires showed a percentage score of 87% in the very high category.
How much water is there within calcium silicate hydrates? Probing water dynamics by Inelastic Neutron Scattering and Molecular Dynamics Simulations
Authors: Zhakiyeva Zhanar , Magnin Valérie , Poulain Agnieszka , Campillo Sylvain , Pilar Asta María , Besselink Rogier , Gaboreau Stéphane , Claret Francis , Grangeon Sylvain , Rudic Svemir , Rols Stéphane , Jiménez-Ruiz Mónica , Bourg Ian C. , Van Driessche Alexander E.S. , Cuello Gabriel J. , Fernandez-Martinez Alejandro
Published: January 2024

Calcium silicate hydrate (C-S-H) is a disordered, nanocrystalline material acting as the primary binding phase in Portland cement. Thin films of water are present on the surfaces and inside the nanopores of C-S-H and related phases such as calcium-aluminum-silicate-hydrate (C-A-S-H), an Al-bearing substitute present in low-CO2 C-S-H cement. These water films control many of the chemical and mechanical properties of C-S-H, including drying shrinkage, ion transport, creep, and thermal behavior. Therefore, obtaining a fundamental understanding of their properties is essential. In this work, we have applied a combination of inelastic incoherent neutron scattering and molecular dynamics simulation methods to unravel the dynamics of water in synthetic C-(A)-S-H samples conditioned at five hydration states (from dry to fully hydrated) and with three different Ca/Si ratios (0.9, 1, and 1.3). Our results converge towards a picture where the evolution from thin layers of adsorbed water to bulk capillary water is dampened by the structure of C-(A)-S-H, in particular by the availability of Ca2+ sites which tend to keep the water in the form of structured surface layers.
Estribec: Fast, Precise Estimation of Stribeck Curves in Tribology
Authors: Takahashi Kei-ichiro , Sakakibara Keita , Watanabe Hiroshi , Tsujii Yoshinobu , Mamitsuka Hiroshi
Published: January 2024

Tribology is the study on friction, wear and lubrication for contacting and moving two solid materials with fluid lubricants. Friction can be found easily in our life and should be reduced, and lubricants are a powerful answer for this purpose. The mechanism behind friction and lubrication has been primarily analyzed by the Stribeck curve, which should be 1) interpretable, 2) non-homogeneous in variances and 3) a mixture of Stribeck curves further. We propose a machine learning approach, Estribec, to estimate the Stribeck curves from observed data in tribology. Estribec is, considering all above three characteristics, a finite mixture model, with a component of a piecewise function, where each piece is a comprehensible simple (primarily, linear) function with a unique variance. Entirely our method keeps linear time complexity for all processes, including parameter estimation and prediction. Empirical results with synthetic data showed Estribec achieved favorable predictive performance against Gaussian process regression (GPR) and its tree variant (TGPR). Importantly Estribec ran always around 20 to 150 times faster than GPR and TGPR, which would be a sizable difference for conducting high-throughput experiments. Finally Estribec showed latent properties of real data which would be useful for tribology research.