bluuebunny/crossref_metadata_2025 huggingface dataset:
DNA Double-Strand Breaks Relieve USF-Mediated Repression of Dβ2 Germline Transcription in Developing Thymocytes
Authors: Stone Jennifer L. , McMillan Ruth E. , Skaar David A. , Bradshaw Justin M. , Jirtle Randy L. , Sikes Michael L.
Published: January 2012

Activation of germline promoters is central to V(D)J recombinational accessibility, driving chromatin remodeling, nucleosome repositioning, and transcriptional read-through of associated DNA. We have previously shown that of the two TCRβ locus (Tcrb) D segments, Dβ1 is flanked by an upstream promoter that directs its transcription and recombinational accessibility. In contrast, transcription within the DJβ2 segment cluster is initially restricted to the J segments and only redirected upstream of Dβ2 after D-to-J joining. The repression of upstream promoter activity prior to Tcrb assembly correlates with evidence that suggests DJβ2 recombination is less efficient than that of DJβ1. Because inefficient DJβ2 assembly offers the potential for V-to-DJβ2 recombination to rescue frameshifted V-to-DJβ1 joints, we wished to determine how Dβ2 promoter activity is modulated upon Tcrb recombination. In this study, we show that repression of the otherwise transcriptionally primed 5′Dβ2 promoter requires binding of upstream stimulatory factor (USF)-1 to a noncanonical E-box within the Dβ2 12-recombination signal sequence spacer prior to Tcrb recombination. USF binding is lost from both rearranged and germline Dβ2 sites in DNA-dependent protein kinase, catalytic subunit-competent thymocytes. Finally, genotoxic dsDNA breaks lead to rapid loss of USF binding and gain of transcriptionally primed 5′Dβ2 promoter activity in a DNA-dependent protein kinase, catalytic subunit-dependent manner. Together, these data suggest a mechanism by which V(D)J recombination may feed back to regulate local Dβ2 recombinational accessibility during thymocyte development.
Adjuvant Immunotherapy of Experimental Autoimmune Encephalomyelitis: Immature Myeloid Cells Expressing CXCL10 and CXCL16 Attract CXCR3+CXCR6+ and Myelin-Specific T Cells to the Draining Lymph Nodes Rather Than the Central Nervous System
Authors: O’Connor Richard A. , Li Xujian , Blumerman Seth , Anderton Stephen M. , Noelle Randolph J. , Dalton Dyana K.
Published: January 2012

CFA is a strong adjuvant capable of stimulating cellular immune responses. Paradoxically, adjuvant immunotherapy by prior exposure to CFA or live mycobacteria suppresses the severity of experimental autoimmune encephalomyelitis (EAE) and spontaneous diabetes in rodents. In this study, we investigated immune responses during adjuvant immunotherapy of EAE. Induction of EAE in CFA-pretreated mice resulted in a rapid influx into the draining lymph nodes (dLNs) of large numbers of CD11b+Gr-1+ myeloid cells, consisting of immature cells with ring-shaped nuclei, macrophages, and neutrophils. Concurrently, a population of mycobacteria-specific IFN-γ–producing T cells appeared in the dLNs. Immature myeloid cells in dLNs expressed the chemokines CXCL10 and CXCL16 in an IFN-γ–dependent manner. Subsequently, CD4+ T cells coexpressing the cognate chemokine receptors CXCR3 and CXCR6 and myelin oligodendrocyte glycoprotein (MOG)-specific CD4+ T cells accumulated within the chemokine-expressing dLNs, rather than within the CNS. Migration of CD4+ T cells toward dLN cells was abolished by depleting the CD11b+ cells and was also mediated by the CD11b+ cells alone. In addition to altering the distribution of MOG-specific T cells, adjuvant treatment suppressed development of MOG-specific IL-17. Thus, adjuvant immunotherapy of EAE requires IFN-γ, which suppresses development of the Th17 response, and diverts autoreactive T cells away from the CNS toward immature myeloid cells expressing CXCL10 and CXCL16 in the lymph nodes.
Skewing of the NK Cell Repertoire by MHC Class I via Quantitatively Controlled Enrichment and Contraction of Specific Ly49 Subsets
Authors: Brodin Petter , Lakshmikanth Tadepally , Kärre Klas , Höglund Petter
Published: January 2012

A major task for the immune system is to secure powerful immune reactions while preserving self-tolerance. This process is particularly challenging for NK cells, for which tolerizing inhibitory receptors for self-MHC class I is both cross-reactive and expressed in an overlapping fashion between NK cells. We show in this study that during an education process, self-MHC class I molecules enrich for potentially useful and contract potentially dangerous NK cell subsets. These processes were quantitatively controlled by the expression level of the educating MHC class I allele, correlated with susceptibility to IL-15 and sensitivity to apoptosis in relevant NK cell subsets, and were linked to their functional education. Controlling the size of NK cell subsets with unique compositions of inhibitory receptors may represent one mechanism by which self-MHC class I molecules generate a population of tolerant NK cells optimally suited for efficient missing self-recognition.
Distinct Kinetics of Gag-Specific CD4+ and CD8+ T Cell Responses during Acute HIV-1 Infection
Authors: Riou Catherine , Ganusov Vitaly V. , Campion Suzanne , Mlotshwa Mandla , Liu Michael K. P. , Whale Victoria E. , Goonetilleke Nilu , Borrow Persephone , Ferrari Guido , Betts Michael R. , Haynes Barton F. , McMichael Andrew J. , Gray Clive M.
Published: January 2012

HIV infection is characterized by a gradual deterioration of immune function, mainly in the CD4 compartment. To better understand the dynamics of HIV-specific T cells, we analyzed the kinetics and polyfunctional profiles of Gag-specific CD4+ and CD8+ T cell responses in 12 subtype C-infected individuals with different disease-progression profiles, ranging from acute to chronic HIV infection. The frequencies of Gag-responsive CD4+ and CD8+ T cells showed distinct temporal kinetics. The peak frequency of Gag-responsive IFN-γ+CD4+ T cells was observed at a median of 28 d (interquartile range: 21–81 d) post-Fiebig I/II staging, whereas Gag-specific IFN-γ+CD8+ T cell responses peaked at a median of 253 d (interquartile range: 136–401 d) and showed a significant biphasic expansion. The proportion of TNF-α–expressing cells within the IFN-γ+CD4+ T cell population increased (p = 0.001) over time, whereas TNF-α–expressing cells within IFN-γ+CD8+ T cells declined (p = 0.005). Both Gag-responsive CD4+ and CD8+ T cells showed decreased Ki67 expression within the first 120 d post-Fiebig I/II staging. Prior to the disappearance of Gag-responsive Ki67+CD4+ T cells, these cells positively correlated (p = 0.00038) with viremia, indicating that early Gag-responsive CD4 events are shaped by viral burden. No such associations were observed in the Gag-specific CD8+ T cell compartment. Overall, these observations indicated that circulating Gag-responsive CD4+ and CD8+ T cell frequencies and functions are not synchronous, and properties change rapidly at different tempos during early HIV infection.
Oral Alveolar Rhabdomyosarcoma: A Case Report with Immunohistochemical Analysis
Authors: Astekar Madhusudan , Metgud Rashmi , Sharma Priyanka , Ramesh Gayatri
Published: January 2012

Rhabdomyosarcomas are among the most common soft-tissue tumors in children. These tumors are derived from mesenchymal tissue with a tendency toward myogenic differentiation that probably originates from immature and highly invasive satellite cells associated with the embryogenesis of skeletal muscle. Some of these tumors are associated with high rates of recurrence and metastasis. The diagnosis is made by microscopic analysis and auxiliary techniques such as immunohistochemistry, electron microscopy, cytogenetic analysis, and molecular biology. We report a case of 28- year-old man who presented with a painless progressive swelling of gingiva since 3 months, which was gradually increasing in size without any systemic symptoms or signs of any metastatic spread. An incisional biopsy was done and histopathology reported an alveolar variant of rhabdomyosarcoma. Immuno - histochemistry with panel of markers was done which showed positivity for CD99, vimentin and negative for desmin and myogenin. So the characteristic immunohistological expression was negative in present case. Hence we conclude that haematoxylin and eosin morphology and ultra structure are needed to classify rhabdomyosarcoma and immunohistochemistry act only as an auxiliary.
Religie en macht: Theoretische invalshoeken in verband met het Nieuwe Testament
Authors: Van Henten Jan-Willem
Published: January 2012

Religion and power. Theoretical perspectives in connection with the New Testament. This contribution is the slightly adapted introductory lecture given at the conference on Power and the New Testament held in Stellenbosch from 16−18 January 2011. It offers (1) a survey of some of the relevant scholarly contributions on the concept of power and the nexus of power and religion, and (2) a brief discussion of possible avenues for analyzing the theme of power in New Testament passages.
A Hybrid Approach to Sentiment Sentence Classification in Suicide Notes
Authors: Sohn Sunghwan , Torii Manabu , Li Dingcheng , Wagholikar Kavishwar , Wu Stephen , Liu Hongfang
Published: January 2012

This paper describes the sentiment classification system developed by the Mayo Clinic team for the 2011 I2B2/VA/Cincinnati Natural Language Processing (NLP) Challenge. The sentiment classification task is to assign any pertinent emotion to each sentence in suicide notes. We have implemented three systems that have been trained on suicide notes provided by the I2B2 challenge organizer–-a machine learning system, a rule-based system, and a system consisting of a combination of both. Our machine learning system was trained on re-annotated data in which apparently inconsistent emotion assignment was adjusted. Then, the machine learning methods by RIPPER and multinomial Naïve Bayes classifiers, manual pattern matching rules, and the combination of the two systems were tested to determine the emotions within sentences. The combination of the machine learning and rule-based system performed best and produced a micro-average F-score of 0.5640.
Fine-Grained Emotion Detection in Suicide Notes: A Thresholding Approach to Multi-Label Classification
Authors: Luyckx Kim , Vaassen Frederik , Peersman Claudia , Daelemans Walter
Published: January 2012

We present a system to automatically identify emotion-carrying sentences in suicide notes and to detect the specific fine-grained emotion conveyed. With this system, we competed in Track 2 of the 2011 Medical NLP Challenge, 14 where the task was to distinguish between fifteen emotion labels, from guilt, sorrow, and hopelessness to hopefulness and happiness.

Since a sentence can be annotated with multiple emotions, we designed a thresholding approach that enables assigning multiple labels to a single instance. We rely on the probability estimates returned by an SVM classifier and experimentally set thresholds on these probabilities. Emotion labels are assigned only if their probability exceeds a certain threshold and if the probability of the sentence being emotion-free is low enough. We show the advantages of this thresholding approach by comparing it to a naïve system that assigns only the most probable label to each test sentence, and to a system trained on emotion-carrying sentences only.
Emotion Detection in Suicide Notes using Maximum Entropy Classification
Authors: Wicentowski Richard , Sydes Matthew R.
Published: January 2012

An ensemble of supervised maximum entropy classifiers can accurately detect and identify sentiments expressed in suicide notes. Using lexical and syntactic features extracted from a training set of externally annotated suicide notes, we trained separate classifiers for each of fifteen pre-specified emotions. This formed part of the 2011 i2b2 NLP Shared Task, Track 2. The precision and recall of these classifiers related strongly with the number of occurrences of each emotion in the training data. Evaluating on previously unseen test data, our best system achieved an F1 score of 0.534.
North Atlantic Oscillation and tropospheric ozone variability in Europe: model analysis and measurements intercomparison
Authors: Pausata F. S. R. , Pozzoli L. , Vignati E. , Dentener F. J.
Published: January 2012

Abstract. Ozone pollution represents a serious health and environmental problem. While ozone pollution is mostly produced by photochemistry in summer, elevated ozone concentrations can also be influenced by long range transport driven by the atmospheric circulation and stratospheric ozone intrusions. We analyze the role of large scale atmospheric circulation variability in the North Atlantic basin in determining surface ozone concentrations. Here, we show, using ground station measurements and a coupled atmosphere-chemistry model simulation for the period 1980–2005, that the North Atlantic Oscillation (NAO) does affect surface ozone concentrations – on average, over 10 ppbv on the monthly mean in southwestern, central and northern Europe – during all seasons except fall. The commonly used NAO index is able to capture the link existing between atmospheric dynamics and surface ozone concentrations in winter and spring but it fails in summer. We find that the first Principal Component, computed from the time variation of the sea level pressure (SLP) field, detects the atmosphere circulation/ozone relationship not only in winter and spring but also during summer, when the atmospheric circulation weakens and regional photochemical processes peak. The first Principal Component of the SLP field could be used as a tool to identify areas more exposed to forthcoming ozone pollution events. Finally, our results suggest that the increasing baseline ozone in western and northern Europe during the 1990s could be related to the prevailing phase of the NAO in that period.
Stochastic parameterization of dust emission and application to convective atmospheric conditions
Authors: Klose M. , Shao Y.
Published: January 2012

Abstract. We develop a parameterization scheme of convective dust emission for regional and global atmospheric models. Convective dust emission occurs in the absence of saltation as large eddies intermittently produce strong shear stresses on the surface and thereby entrain dust particles into the air. The new scheme presented here takes account of the stochastic nature of convective dust emission. It consists of the statistical representations of soil particle size, inter-particle cohesion and instantaneous surface shear stress. A method of determining the probability density function of the latter quantity is proposed. Dust emission is then estimated from the overlap of the probability density functions of the aerodynamic lifting and inter-particle cohesive forces. The new scheme is implemented into the WRF/Chem model and applied to dust modeling in the Taklimakan Desert. A comparison with lidar data shows that the model can reproduce the main features of the dust patterns and their diurnal variations. For the case studied, convective dust emission is typically several μg m−2 s−1 and at times up to 50 μg m−2 s−1.
Tracing the spatial propagation of river inlet water into an agricultural polder area using anthropogenic gadolinium
Authors: Rozemeijer J. , Siderius C. , Verheul M. , Pomarius H.
Published: January 2012

Abstract. The inlet of diverted river water into agricultural areas or nature reserves is a frequently applied management strategy to prevent fresh water shortage. However, the inlet water might have negative consequences for water quality in the receiving water bodies. This study aimed to obtain a spatial image of the inlet water propagation into a hydrological complex polder area. We used anthropogenic gadolinium (Gd-anomaly) as a tracer for diverted river water. A clear reduction in the river water contribution was found from very dry conditions on 5 August 2010 to very wet conditions on 22 October. Despite the large inlet water impact on 5 August, the diverted river water did not propagate up into the small agricultural headwater ditches. Gadolinium proved to be an effective tracer for diverted river water in a polder system. We applied our results to upgrade the interpretation of water quality monitoring data and to validate our integrated nutrient transport models.
Propagation and dissipation of internal tides in the Oslofjord
Authors: Staalstrøm A. , Aas E. , Liljebladh B.
Published: January 2012

Abstract. Observations of velocity, pressure, temperature and salinity in the inner Oslofjord have been analysed. The data is used to provide new information about energy dissipation and mixing efficiency of internal tides generated by tidal current across the Drøbak Sill. The ratio between the observed amplitude of the internal wave in the pycnocline and the amplitude of the surface elevation is in the range 38 ± 6 at a distance of 1 km inside the sill and 11 ± 2 at 10 km. The energy flux of the internal wave propagating from the Drøbak Sill into the inner fjord is estimated to vary in the range 155–480 kW. This is the same order of magnitude as the estimated baroclinic energy loss (250 kW). Approximately 40–70% of this energy flux is dissipated within a distance of 7 km from the sill. The mixing efficiency is estimated to 0.09–0.11 based on energy density and group velocity, and 0.22–0.26 based on perturbation pressure and baroclinic velocity. These numbers are larger than earlier estimates. Only a fraction in the range 0.01–0.03 is transferred to work against buoyancy in the first basin within a distance of 7 km from the sill.
Glacier changes and climate trends derived from multiple sources in the data scarce Cordillera Vilcanota region, Southern Peruvian Andes
Authors: Salzmann N. , Huggel C. , Rohrer M. , Silverio W. , Mark B. G. , Burns P. , Portocarrero C.
Published: January 2012

Abstract. The role of glaciers as temporal water reservoirs is particularly pronounced in the (outer) tropics because of the very distinct wet-dry seasons. Rapid glacier retreat caused by climatic changes is thus a major concern and decision makers demand urgently for regional/local glacier evolution trends, ice mass estimates and runoff assessments. However, in remote mountain areas, spatial and temporal data coverage is typically very scarce and this is further complicated by a high spatial and temporal variability in regions with complex topography. Here, we present an approach on how to deal with these constraints. For the Cordillera Vilcanota (Southern Peruvian Andes), which is the second largest glacierised Cordillera in Peru (after the Cordillera Blanca) and also comprises the Quelccaya Ice Cap, we assimilate a comprehensive multi-decadal collection of available glacier and climate data from multiple sources (satellite images, meteorological station data and climate Reanalysis), and analyze them for respective changes in glacier area and volume and related trends in air temperature, precipitation and specific humidity. In general, the climate data show a moderate (compared to other alpine regions) increase in air temperature, weak and not significant trends for precipitation sums, and an increase in specific humidity at the 500 hPa level. The latter is consistent with observed increase in water vapour at the tropopause level during the past decades. It is likely that the increase in specific humidity played a major role in the observed massive ice loss of the Cordillera Vilcanota over the past decades.
Barrier Evaluation by Linearly Increasing Voltage Technique Applied to Si Solar Cells and Irradiated Pin Diodes
Authors: Gaubas E. , Ceponis T. , Kalendra V. , Kusakovskij J. , Uleckas A.
Published: January 2012

Technique for barrier evaluation by measurements of current transients induced by linearly increasing voltage pulse based on analysis of barrier and diffusion capacitance changes is presented. The components of the barrier capacitance charging and generation/recombination currents are discussed. Different situations of the impact of deep center defects on barrier and diffusion capacitance changes are analyzed. Basics of the profiling of layered junction structures using the presented technique are discussed. Instrumentation for implementation of this technique and for investigations of the steady-state bias infra-red illumination and temperature dependent variations of the barrier capacitance charging and generation/recombination currents are described. Applications of this technique for the analysis of barrier quality in solar cells and particle detectors fabricated on silicon material are demonstrated.
The Popcorn Box Activity and Reasoning about Optimization
Authors: Whiteley Walter J. , Mamolo Ami
Published: January 2012

Investigating rates of change in volume without calculation leads to an enriched sense of the optimization process and encourages reflection and connection among different approaches.
A Natural Approach to the Number e
Authors: Doerr Helen M. , Meehan Donna J. , O'Neil AnnMarie H.
Published: January 2012

Building on prior knowledge of slope, this approach helps students develop the ability to approximate and interpret rates of change and lays a conceptual foundation for calculus.
Insurance Disparities in Quality of Care Among Patients With Head and Neck Cancer
Authors: Megwalu Uchechukwu C. , Ma Yifei , Divi Vasu , Tian Lu
Published: June 2024

Importance

Significant insurance status disparities have been demonstrated in head and neck cancer (HNC) outcomes. The effects of insurance status on HNC outcomes may be explained by differential access to high-quality care.

Objective

To evaluate the association of insurance status with the quality of the treating hospital and receipt of guideline-compliant care among patients with HNC.

Design, Setting, and Participants

This retrospective cohort study of data from the California Cancer Registry dataset linked with discharge records and hospital characteristics from the California Department of Health Care Access and Information included adult patients with HNC diagnosed between January 1, 2010, and December 31, 2019. Data were analyzed from May 10, 2023, to March 25, 2024.

Exposures

Insurance status: commercial, Medicare, Medicaid, uninsured, other, or unknown.

Main Outcomes and Measures

Quality of the treating hospital (tertiles), receipt of National Comprehensive Cancer Network guideline-compliant care, and overall survival.

Results

A total of 23 933 patients (mean [SD] age, 64.8 [12.3] years; 75.3% male) met the inclusion criteria. Treatment in top-tertile hospitals (hazard ratio, 0.87; 95% CI, 0.79-0.95) was associated with improved overall survival compared with treatment in bottom-tertile hospitals. Medicare (odds ratio [OR], 0.78; 95% CI, 0.73-0.84), Medicaid (OR, 0.60; 95% CI, 0.54-0.66), and uninsured (OR, 0.38; 95% CI, 0.29-0.49) status were associated with lower likelihood of treatment in high-quality hospitals compared with commercial insurance. Among patients with advanced disease, Medicaid (OR, 0.72; 95% CI, 0.62-0.83) and uninsured (OR, 0.64; 95% CI, 0.44-0.93) patients were less likely to receive dual-modality therapy. Among patients with surgically resected advanced disease, Medicaid coverage (OR, 0.73; 95% CI, 0.58-0.93) was associated with lower likelihood of receiving adjuvant radiotherapy.

Conclusions and Relevance

This study found significant insurance disparities in quality of care among patients with HNC. These findings highlight the need for continued health insurance reform in the US to improve the quality of insurance coverage, in addition to expanding access to health insurance.
How many patients do you need? Investigating trial designs for anti‐seizure treatment in acute brain injury patients
Authors: Parikh Harsh , Sun Haoqi , Amerineni Rajesh , Rosenthal Eric S. , Volfovsky Alexander , Rudin Cynthia , Westover M. Brandon , Zafar Sahar F.
Published: June 2024

Background/objectives

Epileptiform activity (EA), including seizures and periodic patterns, worsens outcomes in patients with acute brain injuries (e.g., aneurysmal subarachnoid hemorrhage [aSAH]). Randomized control trials (RCTs) assessing anti‐seizure interventions are needed. Due to scant drug efficacy data and ethical reservations with placebo utilization, and complex physiology of acute brain injury, RCTs are lacking or hindered by design constraints. We used a pharmacological model‐guided simulator to design and determine the feasibility of RCTs evaluating EA treatment.

Methods

In a single‐center cohort of adults (age >18) with aSAH and EA, we employed a mechanistic pharmacokinetic‐pharmacodynamic framework to model treatment response using observational data. We subsequently simulated RCTs for levetiracetam and propofol, each with three treatment arms mirroring clinical practice and an additional placebo arm. Using our framework, we simulated EA trajectories across treatment arms. We predicted discharge modified Rankin Scale as a function of baseline covariates, EA burden, and drug doses using a double machine learning model learned from observational data. Differences in outcomes across arms were used to estimate the required sample size.

Results

Sample sizes ranged from 500 for levetiracetam 7 mg/kg versus placebo, to >4000 for levetiracetam 15 versus 7 mg/kg to achieve 80% power (5% type I error). For propofol 1 mg/kg/h versus placebo, 1200 participants were needed. Simulations comparing propofol at varying doses did not reach 80% power even at samples >1200.

Conclusions

Our simulations using drug efficacy show sample sizes are infeasible, even for potentially unethical placebo‐control trials. We highlight the strength of simulations with observational data to inform the null hypotheses and propose use of this simulation‐based RCT paradigm to assess the feasibility of future trials of anti‐seizure treatment in acute brain injury.
KOH Activated Carbon Coated 3D Wood Solar Evaporator with Highest Water Transport Height and Evaporation Rate for Clean Water Production
Authors: Zhang Mengxue , Hu Nan , Guo Yang , Wu Wenhao , Fan Liwu , Lin Daohui , Wang Juan , Yang Kun
Published: June 2024

The water evaporation rate of 3D solar evaporator heavily relies on the water transport height of the evaporator. In this work, a 3D solar evaporator featuring a soil capillary‐like structure is designed by surface coating native balsa wood using potassium hydroxide activated carbon (KAC). This KAC‐coated wood evaporator can transport water up to 32 cm, surpassing that of native wood by ≈8 times. Moreover, under 1 kW m−2 solar radiation without wind, the KAC‐coated wood evaporator exhibits a remarkable water evaporation rate of 25.3 kg m−2 h−1, ranking among the highest compared with other reported evaporators. The exceptional water transport capabilities of the KAC‐coated wood should be attributed to the black and hydrophilic KAC film, which creates a porous network resembling a soil capillary structure to facilitate efficient water transport. In the porous network of coated KAC film, the small internal pores play a pivotal role in achieving rapid capillary condensation, while the larger interstitial channels store condensed water, further promoting water transport up more and micropore capillary condensation. Moreover, this innovative design demonstrates efficacy in retarding phenol from wastewater through absorption onto the coated KAC film, thus presenting a new avenue for high‐efficiency clean water production.
Structural Degradation of M‐N‐C (M=Co, Ni and Fe) Single‐Atom Electrocatalysts at Industrial‐Grade Current Density for Long‐Term Reduction
Authors: Ruan Qingqing , Lu Shanshan , Wu Jiaqi , Shi Yanmei , Zhang Bin
Published: June 2024

M‐N‐C single‐atom catalysts (SACs) are promising electrode materials for many electro‐reduction reactions. However, their stability is far from practical applications, and their deactivation mechanism has been rarely investigated. Herein, we demonstrate the structural degradation of M‐N‐C (M=Co, Ni, and Fe) at industrial‐grade current density for long‐term electro‐reduction. Both M‐N and N‐C bonds are broken, resulting in the gradual hydrogenation and dissolution of N in the form of ammonia. The residual M is finally converted to M‐containing core–shell nanoparticles after sequential dissolution, redeposition, and electro‐reduction. The destruction of the M‐N‐C structure and the formation of nanoparticles greatly affect the electrocatalytic performance. Our work highlights the structural degradation and deactivation mechanism of M‐N‐C‐type SACs under strong reductive conditions and provides useful information for inspiring researchers to develop new strategies to improve the electrocatalytic stability of similar types of materials.
Sustainable and resilient cold chains: Enhancing adaptability, consistency, and digital transformation for success in a turbulent market
Authors: Vandana  , Sangwa Narpat Ram , Ertz Myriam , Shashi
Published: June 2024

Sustainable and resilient cold chains (CC) are the backbone of several industries, ensuring the seamless transport and storage of temperature‐sensitive products ranging from fresh produce and pharmaceuticals to life‐saving vaccines. Particularly in times of disruptions, such as natural disasters or global health crises, the sustainability and resilience of CCs become even more crucial, highlighting the urgent need for research, innovation, and strategic planning in this domain. This study conducted a systematic review of the sustainable and resilient CC research literature. A total of 143 high‐quality articles were shortlisted from the Web‐of‐Science (WoS) database for in‐depth content analysis. This review clarifies the existing results and highlights the trending themes and persistent gaps in research pertaining to CC in a business context and at a strategic level. It covers notably disruptions and related impacts, the relationship between sustainability and resilience in CC, decision tools for sustainable and resilient CC, CC sustainability and resilience performance areas and measurement metrics, data‐driven digital transformation for sustainable and resilient CC, and strategies for developing sustainable and resilient CC strategies. The results reveal that research on sustainable and resilient CC is growing; however, the field remains dominated by research methods that need to establish causality formally. Furthermore, the research area is fragmented into several subareas, and more conceptual and theoretical work is needed to advance the theoretical foundation of the domain. Finally, a proposed research agenda suggests 17 future avenues for improving the contribution to sustainable and resilient CC research.
Sustainable business models and organizational boundaries—A literature review
Authors: Bjartmarz Thordis Katla , Bocken Nancy M. P.
Published: June 2024

Social and environmental challenges are forcing organizations to develop sustainable business models (SBMs). Literature on SBMs has identified the importance of stakeholders and collaboration. Collaboration and positions of stakeholders within the value‐chain opens the discussion about organizational boundaries and their role in enhancing or hindering sustainable business model innovation. Through a literature review, this study analyzes 53 papers at the intersection of SBMs and boundaries to clarify how SBMs change organizational boundaries, and how these boundaries affect the sustainability values of organizations. We aim to identify key stakeholders, who hold negotiation power at organizational boundaries. The paper identifies important managerial questions that may assist organizations in the process of unpacking sustainable value and broaden their scope of key stakeholders. Finally, we formulate future research areas to advance research at the intersection of SBMs and organizational boundaries.
The conceptus and its parts: ontogenetic recapitulation in early human development
Authors: Freeman Brian
Published: June 2024

Our understanding of the processes of human development that occur during and just after implantation is still incomplete. The anatomical studies by Erich Blechschmidt (1904–1992) at the University of Göttingen demonstrate the uniqueness and beauty of the early stages of individual human development or ontogeny. The interpretations of human embryology by Blechschmidt offer a simple unifying hypothesis: metabolic and biomechanical events are repeated, and this can be described as an ontogenetic recapitulation. This commentary provides a rationale for using some older terms and introducing new ones in the description of early human development. The product of conception is a conceptus; the outer part of the conceptus is the ectoblast and everything inside is the endoblast; the endocyst arises in the endoblast when the future amniotic fluid is forming. The human embryo arises from the innermost part of the endocyst. Terms such as morula, gastrula, and cyema, which are imported from zoology and ignore the role of the zona pellucida and constrained fluid compartments in the conceptus, can be avoided.
NJCAA offers new solution for health, wellness services
Authors: McCarthy Claudine
Published: June 2024

In a time of skyrocketing healthcare costs and understaffed counseling centers, the NJCAA has found an innovative, cost‐effective way to improve access to quality health and wellness services for not only the student‐athletes at two‐year colleges, but their campus communities as a whole. This includes all students (not just student‐athletes), staff, faculty, adjuncts, and international students.
Pyridyl‐Substituted Nitronyl Nitroxides: Comprehensive Magnetochemical and Quantum Chemical Study
Authors: Chernavin Platon A. , Letyagin Gleb A. , Tolstikov Svyatoslav E. , Kolesnikov Andrey E. , Romanenko Galina V. , Smirnova Kristina A. , Borodulina Alexandra V. , Ovcharenko Victor I. , Bogomyakov Artem S.
Published: June 2024

A series of pyridyl‐substituted nitronyl nitroxides was synthesized and structurally characterized. A comprehensive magnetochemical and quantum chemical study of extended raw of the nitroxides with different substituents R in the pyridine fragment was performed. It was shown, that temperature‐dependent magnetic properties are determined by the short contacts between nitroxide groups of adjacent molecules as well as between nitroxide group and methyl substituents in the pseudo axial positions of imidazoline fragments. Quantum chemistry allows to select the appropriate model of exchange cluster for analysis of experimental magnetic data and evaluation of the exchange interaction parameters. For NN–PyCl the “order‐disorder” transition was detected by means of low temperature XRD. The difference in the experimental and calculated exchange interaction energies may serve as an indicator of temperature‐induced structural rearrangements. For instance, for methyl substituted nitronyl nitroxide NN‐PyMe structural transformations and significant changes in exchange interaction energies were observed.
Redox Active Ligands for Catalyzing the Hydrogen Evolution Reaction
Authors: Kumar Sachin , Fite Shachar , Remigi Erika , Mizrahi Amir , Fridman Natalia , Mahammed Atif , Bender Timothy P. , Gross Zeev
Published: June 2024

Boron subphthalocyanines with chloride and fluoride axial ligands and three antimony complexes chelated by corroles that differ in size and electron‐richness were examined as electrocatalysts for reduction of protons to hydrogen. Experiment‐ and computation‐based investigations revealed that all redox events are ligand‐centered and that the meso‐C of the corroles and the peripheral N atoms of the subphthalocyanines are the largely preferred proton‐binding sites.
An efficient security and privacy approach for internet of vehicles in vehicular networks for smart cities
Authors: Kariri Elham
Published: June 2024

Intelligent sensing plays a crucial role in making vehicles safe and trouble‐free. The purpose of this paper is to introduce Vehicular Sensor Networks (VSNs) in a vehicular IoT‐based smart city paradigm, focusing on security. Furthermore, we discuss the robustness and reliability of VSN. In this design, Ad hoc On‐Demand Distance Vector (AODV) routing‐based Internet of Vehicles is integrated with a privacy‐aware secure ant colony optimization for smart cities in which suspicious vehicles are prevented from disseminating messages. IoV real‐time communication emphasizes data security. A comparison of experimental results shows that the proposed approach outperforms existing approaches. Smart city communication networks can be optimized using the proposed model.
Analysis of the Swedish Knee Ligament Register: Concomitant injuries, revision surgery and smoking render worse results
Authors: Lindqvist Bueneman Sofia , Sernert Ninni , Kvist Joanna , Kartus Jüri‐Toomas
Published: June 2024

Purpose

To analyse the 52,199 patients in the Swedish Knee Ligament Register (SKLR) preoperatively, and the patients reaching 5‐ and 10‐year follow‐ups who underwent anterior cruciate ligament reconstruction (ACLR), revision ACLR and ACLR on the contralateral side (CACLR). The main hypothesis was that patients undergoing revision ACLR would have worse patient‐reported outcome measurements (PROMs) than the primary ACLR group at 10 years and that smoking and concomitant injuries would result in poorer outcomes for all groups.

Methods

Data from 2005 to 2021 were extracted from the SKLR. Only patients whose ACLR surgery was registered in the SKLR were included for revision ACLR and CACLR. The PROMs consist of the Knee injury and Osteoarthritis Outcome Score (KOOS) and the knee‐specific PROM (EQ‐5D‐3L). PROMs were analysed as a whole and in subgroups based on sex, smoking, graft choice and concomitant injuries.

Results

Poorer KOOS were seen for revisions compared with primary ACLRs at both the 5‐ and 10‐year follow‐ups (p = 0.003). Smokers had significantly poorer KOOS than nonsmokers (p < 0.001) preoperatively in all groups, however only in the primary ACLR group at 5 and 10 years. At 10 years, patients who had undergone CACLR had lower KOOS than primary ACLRs (p = 0.03). Concomitant injuries resulted in statistically, significantly poorer KOOS for both primary ACLRs and CACLRs preoperatively and at the follow‐ups.

Conclusion

The PROMs for revision ACLRs have worse KOOS scores at 10 years compared with the primary ACLRs. The presence of concomitant meniscal or cartilage injuries at the time of ACLR or CACLR were associated with worse PROMs.

Level of Evidence

Level III.
Water‐Soluble Reversible Photo‐Cross‐Linking Polymer Dielectrics
Authors: Cruz Menandro , McKillop Sophia , Tischler Vanessa , Lessard Benoît H.
Published: June 2024

Effective recycling of mixed materials requires the separation of the different components without the need for toxic solvents. One approach involves utilizing a water‐soluble coating with reversible photo‐cross‐linkers, making it robust until end of life where it can then be dissolved in water after de‐cross‐linking. Here, a novel coumarin methacrylate monomer and its nitroxide‐mediated copolymerization to create poly((methacrylic acid)‐co‐(styrene sulfonate)‐co‐(coumarin methacrylate)) for water‐soluble thin films are reported. Under exposure to light, the coumarin functional groups produce reversible [2+2] cycloadditions which cross‐link the resulting polymer films, making them no longer water soluble. Characterization of reversible cross‐linking behavior is reported through changes in contact angle and in situ rheological characterization. The resulting polymers are successfully integrated into metal–insulator–metal capacitors, demonstrating the potential use for water‐soluble reversible photo‐cross‐linkable dielectric materials for organic electronics.
On Wilks' joint moment formulas for embedded principal minors of Wishart random matrices
Authors: Genest C. , Ouimet F. , Richards D.
Published: June 2024

In 1934, the American statistician Samuel S. Wilks derived remarkable formulas for the joint moments of embedded principal minors of sample covariance matrices in multivariate Gaussian populations, and he used them to compute the moments of sample statistics in various applications related to multivariate linear regression. These important but little‐known moment results were extended in 1963 by the Australian statistician A. Graham Constantine using Bartlett's decomposition. In this note, a new proof of Wilks' results is derived using the concept of iterated Schur complements, thereby bypassing Bartlett's decomposition. Furthermore, Wilks' open problem of evaluating joint moments of disjoint principal minors of Wishart random matrices is related to the Gaussian product inequality conjecture.
Four-derivative Yang-Mills couplings in heterotic theory through T-duality
Authors: Garousi Mohammad R.
Published: June 2024

Abstract

This study delves into the dimensional reduction of the classical effective action of heterotic string theory on a circle, along with its T-duality symmetry, with the aim of identifying the bosonic couplings. To achieve this, we propose a truncation scheme for the generalized Buscher rules and the reduced action, specifically targeting the truncation of the nonlinear appearance of the scalar component of the Yang-Mills field in the base space. By imposing this truncated T-duality on the reduced action, we successfully determine the four- derivative bosonic couplings in the minimal basis, where field redefinition is imposed. Notably, these couplings, which are associated with the Lorentz Chern-Simons coupling HΩ, exhibit an exact correspondence with the NS-NS couplings found in the Metsaev-Tseytlin action.

Furthermore, we investigate the bosonic couplings in the maximal basis, where field redefinition is not imposed. In this scenario, the truncated T-duality fixes the effective action up to 17 arbitrary parameters. By assigning specific values to these parameters, we establish a framework in which the NS-NS couplings align with those in the Meissner action. Remarkably, within this scheme, the Yang-Mills couplings precisely coincide with those obtained through the S-matrix method.
Engineering perturbative string duals for symmetric product orbifold CFTs
Authors: Hikida Yasuaki , Schomerus Volker
Published: June 2024

Abstract

Constructing a holographic string theory dual for a CFT in the perturbative, weakly coupled regime is a holy grail for gauge/string dualities that would not only open the door for proofs of the AdS/CFT correspondence but could also provide novel examples of string duals with and without supersymmetry. In this work we consider some marginal perturbation of a family of symmetric product orbifolds in two dimensions. From their correlation functions we engineer a bosonic string theory whose amplitudes are shown to reproduce the CFT correlation function order-by-order both in the coupling and in 1/N. Our derivation does not require to compute and compare correlation functions explicitly but rather relies on a sequence of identities that can be derived using path integral methods. The bosonic string theory we engineer is based on the field content of the Kac-Wakimoto representation of strings in AdS3 with k units of pure NSNS flux, but the interaction terms we obtain are different. They include current algebra preserving interaction terms with one unit of spectral flow.
Stabilised finite element method for Stokes problem with nonlinear slip condition
Authors: Gustafsson Tom , Videman Juha
Published: June 2024

This work introduces a stabilised finite element formulation for the Stokes flow problem with a nonlinear slip boundary condition of friction type. The boundary condition is enforced with the help of an additional Lagrange multiplier representing boundary traction and the stabilised formulation is based on simultaneously stabilising both the pressure and the traction. We establish the stability and the a priori error analyses, and perform a numerical convergence study in order to verify the theory.
The contribution of second primary cancers to the mortality of patients with a first primary breast cancer
Authors: Gonçalves Elisabete , Fontes Filipa , Rodrigues Jéssica Rocha , Calisto Rita , Bento Maria José , Lunet Nuno , Morais Samantha
Published: June 2024

Purpose

Second primary cancers (SPCs) are estimated to affect nearly 5% of patients with breast cancer within 10 years of their diagnosis. This study aimed to estimate the contribution of SPCs to the mortality of patients with a breast first primary cancer (FPC).

Methods

A population-based cohort of 17,210 patients with a breast FPC diagnosed between 2000 and 2010 was followed for SPCs (31/12/2015) and vital status (30/06/2021). Patients diagnosed with an SPC (265 synchronous and 897 metachronous, ≤ 1 and > 1 year after the FPC, respectively) were matched (1:3, by five-year age group and year of breast FPC diagnosis) to those without an SPC and alive when the corresponding SPC was diagnosed.

Results

Significantly higher hazards of death were found among patients with an SPC [hazard ratio of 1.56, 95% confidence interval (CI) 1.29–1.89 for synchronous SPCs; and 2.85, 95%CI 2.56–3.17 for metachronous SPCs] compared to patients with a breast FPC only. Estimates were higher for synchronous lung, stomach, non-Hodgkin lymphoma and breast SPCs, and metachronous liver, stomach, ovary, lung, rectum, corpus uteri, colon, breast, and non-Hodgkin lymphoma SPCs. The 15-year cumulative mortality was 59.5% for synchronous SPCs and 68.7% for metachronous SPCs, which was higher than in patients with a breast FPC only (43.6% and 44.8%, respectively).

Conclusions

In Northern Portugal, patients with an SPC following a breast FPC have a higher mortality compared with patients with a breast FPC only.
LncRNA KIFAP3-5:1 inhibits epithelial-mesenchymal transition of renal tubular cell through PRRX1 in diabetic nephropathy
Authors: Du Lei , Lu Yinfei , Wang Jingyi , Zheng Yijia , Li Huan , Liu Yunfei , Wu Xiaoling , Zhou Jieling , Wang Lei , He Linlin , Shi Jiasen , Xu Liu , Li Xizhi , Lu Qian , Yin Xiaoxing
Published: June 2024

Long noncoding RNAs play an important role in several pathogenic processes in diabetic nephropathy, but the relationship with epithelial-mesenchymal transition in DN is unclear. Herein, we found that KIFAP3-5:1 expression was significantly down-regulated in DN plasma samples, db/db mouse kidney tissues and high glucose treated renal tubular epithelial cells compared to normal healthy samples and untreated cells. Overexpression of KIFAP3-5:1 improved renal fibrosis in db/db mice and rescued epithelial-mesenchymal transition of high glucose cultured renal tubular epithelial cells. The silence of KIFAP3-5:1 will exacerbate the progression of EMT. Mechanistically, KIFAP3-5:1 was confirmed to directly target to the -488 to -609 element of the PRRX1 promoter and negatively modulate PRRX1 mRNA and protein expressions. Furthermore, rescue assays demonstrated that the knockdown of PRRX1 counteracted the KIFAP3-5:1 low expression-mediated effects on EMT in hRPTECs cultured under high glucose. The plasma KIFAP3-5:1 of DN patients is highly correlated with the severity of renal dysfunction and plays an important role in the prediction model of DN diseases. These findings suggested that KIFAP3-5:1 plays a critical role in regulation of renal EMT and fibrosis through suppress PRRX1, and highlight the clinical potential of KIFAP3-5:1 to assist in the diagnosis of diabetic nephropathy.

Graphical abstract