bluuebunny/crossref_metadata_2025 huggingface dataset:
Recent Progress of Supercritical Carbon Dioxide in Producing Natural Nanomaterials
Authors: Xie Maobin , Xu Man , Chen Xiaoming , Li Yi
Published: October 2018

Natural medicines are widely utilized in human healthcare. Their beneficial effects have been attributed to the existence of natural active ingredients (NAI) with a positive impact on disease treatment and prevention. Public awareness about the side effects of synthetic chemical compounds increased the need for NAI as well. Clinical applications of NAI are limited by their instability and poor water solubility, while micronization is a major strategy to overcome these drawbacks. Supercritical carbon dioxide (sc-CO2) based nano techniques have drawn great attention in nanomedicinal area for many years, due to their unique characters such as fast mass transfer, near zero surface tension, effective solvents elimination, non-toxic, non-flammable, low cost and environmentally benign. In terms of functions of sc-CO2, many modified sc-CO2 based techniques are developed to produce NAI nanoparticles with high solubility, biological availability and stability. 5 types of promising methods, including gas-assisted melting atomization, CO2-assisted nebulization with a bubble dryer, supercritical fluidassisted atomization with a hydrodynamic cavitation mixer, supercritical CO2-based coating method and solution-enhanced dispersion by sc-CO2 process, are summarized in this article followed by a highlight of their fundamental synthesis principles and important medicinal applications.
Piers-Rubinsztajn Reaction and the Application in Siloxane/Polysiloxane Chemistry
Authors: Peng Jiajian , Bai Ying , Li Jiayun
Published: October 2018

By using the Piers-Rubinsztajn processes, elastomers, foams, silicone surfactants and copolymers with alkoxy-functional arylamines and ethers can be prepared. The preparation and applications of siloxane-based materials through Piers-Rubinsztajn reaction synthesis pathway have been reviewed.
Potential of Nanoparticles in Combating Candida Infections
Authors: Qais Faizan Abul , Khan Mohd Sajjad Ahmad , Ahmad Iqbal , Althubiani Abdullah Safar
Published: October 2018

Aims:

The aim of this review is to survey the recent progress made in developing the
nanoparticles as antifungal agents especially the nano-based formulations being exploited for the
management of Candida infections.

Discussion:

In the last few decades, there has been many-fold increase in fungal infections including
candidiasis due to the increased number of immunocompromised patients worldwide. The efficacy of
available antifungal drugs is limited due to its associated toxicity and drug resistance in clinical
strains. The recent advancements in nanobiotechnology have opened a new hope for the development
of novel formulations with enhanced therapeutic efficacy, improved drug delivery and low toxicity.

Conclusion:

Metal nanoparticles have shown to possess promising in vitro antifungal activities and
could be effectively used for enhanced and targeted delivery of conventionally used drugs. The synergistic
interaction between nanoparticles and various antifungal agents have also been reported with
enhanced antifungal activity.
Selenium and Autoimmune Diseases: A Review Article
Authors: Sahebari Maryam , Rezaieyazdi Zahra , Khodashahi Mandana
Published: October 2018

Background:

Selenium is an essential trace element with fundamental effects on human biology. Trace elements deficiency is not an uncommon finding in autoimmune diseases. This deficiency may be a consequence of autoimmune diseases or may contribute to their etiology. With regard to evidence showing the association between selenium deficiency and generation of reactive oxygen species and subsequent inflammation, reviewing the role of selenium in collagen vascular diseases could help researchers to devise strategies for managing these diseases.

Objective:

The present study aimed to evaluate the role of selenium and autoimmune rheumatic diseases.

Data Sources:

PubMed, Scopus, Science Direct, and Google Scholar.

Study Eligibility Criteria:

All the studies on the use of selenium without any limitations in terms of the preparation method, administration route, or formulation process were included in the study. The exclusion criteria were: 1) Articles published in languages other than English, 2) Administration of chemical and hormonal drugs rather than selenium, 3) Investigation of the effects of selenium on the autoimmune problems in animal models, and 4) Insufficiency of the presented data or poor description of the applied methods. Furthermore, review articles, meta-analyses, expert opinions, editorial letters, case reports, consensus statements, and qualitative studies were excluded from the study.

Data Extraction:

In this systematic review, articles were evaluated through searching following keywords in combination with selenium: "autoimmune rheumatic diseases "or "scleroderma" or "systemic sclerosis" or "Behcet's disease" or "Sjögren syndrome" or "systemic lupus erythematosus" or "musculoskeletal diseases" or "rheumatoid arthritis" or "vasculitis" or "seronegative arthritis" or "antiphospholipid antibody syndrome".

Results:

Of 312 articles, 280 were excluded and 32 articles were entered in this study. Based on the majority of studies assessing selenium level in patients with collagen vascular diseases, lower selenium levels were observed in these patients. Moreover, the majority of articles showed an improvement in clinical symptoms of collagen vascular diseases compared to controls after the treatment of patients with different dosages of L-selenomethionine.

Conclusion:

A decrease in the serum level of selenium was noted in patients with autoimmune diseases, which may be a risk factor for inflammation and initiation of autoimmunity in these patients. A sufficient quantity of selenium has been shown to contribute to the management of complications of autoimmune diseases and even improved survival in patients with autoimmune diseases, which may be due to the anti-inflammatory effects of selenium. Since this issue is of clinical importance, it can be considered in potential nutrition interventions and have beneficial effects on some autoimmune diseases.
Nutraceutical Potential and Processing Aspects of Oyster Mushrooms (PleurotusSpecies)
Authors: Kumar Krishan
Published: October 2018

Background:

Oyster mushrooms (Pleurotus species) have gained considerable attention of food technologist and nutritionist for their nutraceutical properties. Oyster mushrooms are considered as functional foods due to their richness in functional food ingredients. In recent times, consumption of these mushrooms has increased considerably due to their numerous health benefits. These are potential sources of bioactive components, which are sufficient enough for prevention and treatment of various lifestyle diseases. There are about 200 different species in the genus Pleurotus and these are commonly referred to as “oyster mushrooms”.

Objective:

The study aimed to grasp a collective information on nutraceutical and processing aspects of highly perishable but nutritious oyster mushroom

Results:

Pleurotus ostreatus is the most commonly consumed species all over the world due to its superior flavor, taste and nutraceutical properties. It acts as a source of natural antioxidants which might be beneficial for human health in preventing or reducing oxidative damage. Nutritionally, these species are rich sources of proteins, dietary fibres, β-glucan, vitamin B-complex, vitamin C and minerals. They contain higher proportions of certain amino acids such as methionine, cystine and aspartic acid than other edible mushrooms. Oyster mushrooms have been reported to possess hypocholesterolemic, anti-bacterial, anti-diabetic, anti-oxidant, anti-arthritic, anti-carcinogenic, hepatoprotective, anti-viral activities and act as natural resources of immunotherapy activities. The use of these mushrooms can overcome the deficiency of protein in the developing countries where there is unavailability or unacceptability of good quality proteins from animal sources because of religious restrictions.

Conclusion:

Because of the occurrence of abundant nutritional ingredients and other bioactive components in P. ostreatus, they have a great scope as a potential source for the development of functional or specialty foods for value addition of deficient foods so as to alleviate the nutritional deficiency diseases from society.
Jurisprudence Study of Muslim Rules and Effects of Ovarian Transplants in Women with Infertility; A Review
Authors: Ghodrati Fatemeh , Akbarzadeh Marzieh
Published: October 2018

Background:

The use of assisted reproductive techniques, in addition to mental and emotional stress in different stages, made some jurists, as fatwa authorities, to investigate and evaluate the problems of this type of transplantation.

Objective:

The aim of this study was the jurisprudence investigation of the rules and effects of ovarian transplants in women with infertility.

Methods:

This study was conducted through review and library studies using the keywords ovarian transplants, infertility, jurists’ opinions and religious rules as to ovarian transplantation.

Results:

Permission for transplanting one’s own ovarian tissue was issued through the consent of most scholars of Islamic schools and according to some verses, traditions, legal rules, and logical reasons. Although some of the Ancient religious scholars have dissenting opinions about transplantation, for some jurists, ovarian transplant from a woman to an infertile woman has no legal problem and the infant belongs to the recipient. However, some other jurists oppose this fatwa. They believe that there is a problem in the oocytes and ovarian transplantation due to mixed parentage and the holy legislator does not agree with this transplantation. So, they had opposing fatwa in this regard.

Conclusion:

According to the consensus of some Muslim jurists on ovarian transplant from one’s own ovary or from another woman, there is a new hope for infertile couples to use this method which is done from a woman to another woman.
Carbonic Anhydrase Inhibitory Potential of 1,2,4-triazole-3-thione Derivatives of Flurbiprofen, Ibuprofen and 4-tert-butylbenzoic Hydrazide: Design, Synthesis, Characterization, Biochemical Evaluation, Molecular Docking and Dynamic Simulation Studies
Authors: Abbas Saghir , Zaib Sumera , Ur Rahman Shafiq , Ali Saqib , Hameed Shahid , Tahir Muhammad N. , Munawar Khurram S. , Shaheen Farzana , Abbas Syed M. , Iqbal Jamshed
Published: October 2018

Background:

The over-expression of the carbonic anhydrases results in some specific carcinomas including pancreatic, gastric and brain tumor. Tumors are distinguished under hypoxic conditions and various investigations are being carried out to target the known hypoxic areas of the tumors to increase the sensitivity towards standard therapeutic treatment.

Objective:

Herein, we have designed and synthesized some biologically important esters, hydrazides, thiocarbamates, 1,2,4-triazole-3-thiones and Schiff bases. The purpose of the research was to evaluate the derivative against carbonic anhydrase and to assess the toxicity of the same compounds.

Method:

The structures of all the compounds were characterized by FT-IR, mass spectrometry, elemental analysis, 1H and 13C NMR spectroscopy. The synthetic derivatives were screened for their inhibitory potential against carbonic anhydrase II by in vitro assay. Double reciprocal plots for inhibition kinetics of the potent compounds were constructed and mode of inhibition was determined. Furthermore, to check the cytotoxicity, these derivatives were tested against human breast adenocarcinoma by MTT method.

Results:

X-ray diffraction analysis of the compounds 10, 14 and 15 showed that they did not have any π-π or C-H…&π interactions. The experimental results were validated by molecular docking and dynamic simulations of the potent compounds in the active pocket of enzyme. Important binding interactions of potent compounds with the key residues in the active site of the carbonic anhydrase enzyme were revealed. Drug likeness profile of the derivatives was evaluated to determine the physicochemical properties.

Conclusion:

The proposed synthetic approach provides a suitable platform for the generation of a new library of compounds which could potentially be employed in the future testing and optimization of inhibitor potencies.
Synthesis and Biological Evaluation of Scutellarein Alkyl Derivatives as Preventing Neurodegenerative Agents with Improved Lipid Soluble Properties
Authors: Li He-Min , Gu Ting , Wu Wen-Yu , Yu Shao-Peng , Fan Tian-Yuan , Zhong Yue , Li Nian-Guang
Published: October 2018

Background:

Exogenous antioxidants are considered as a promising therapeutic approach to treat neurodegenerative diseases since they could prevent and/or minimize the neuronal damage by oxidation.

Objective:

Three series of lipophilic compounds structurally based on scutellarein (2), which is one metabolite of scutellarin (1) in vivo, have been designed and synthesized.

Methods:

Their antioxidant activity was evaluated by detecting the 2-thiobarbituric acid reactive substance (TBARS) produced in the ferrous salt/ascorbate-induced autoxidation of lipids, which were present in microsomal membranes of rat hepatocytes. The lipophilicity of these compounds indicated as partition coefficient between n-octanol and buffer was investigated by ultraviolet (UV) spectrophotometer.

Results:

This study indicated that compound 5e which had a benzyl group substituted at the C4'- OH position showed a potent antioxidant activity and good lipophilicity.

Conclusion:

5e could be an effective candidate for preventing or reducing the oxidative status associated with the neurodegenerative processes.
Evaluation of Antiplasmodial Potential of C2 and C8 Modified Quinolines: in vitro and in silico Study
Authors: Kumar Rakesh , Sharma Ritika , Kumar Inder , Upadhyay Pooja , Dhiman Ankit Kumar , Kumar Rohit , Kumar Rakesh , Purohit Rituraj , Sahal Dinkar , Sharma Upendra
Published: October 2018

Background:

Malaria remains a common life-threatening infectious disease across the
globe due to the development of resistance by Plasmodium parasite against most antimalarial
drugs. The situation demands new and effective drug candidates against Plasmodium.

Objectives:

The objective of this study is to design, synthesize and test novel quinoline based
molecules against the malaria parasite.

Methods:

C2 and C8 modified quinoline analogs obtained via C-H bond functionalization approach
were synthesized and evaluated for inhibition of growth of P. falciparum grown in human
red blood cells using SYBR Green microtiter plate based screening. Computational molecular
docking studies were carried out with top fourteen molecules using Autodoc software.

Results:

The biological evaluation results revealed good activity of quinoline-8-acrylate 3f (IC50
14.2 µM), and the 2-quinoline-α-hydroxypropionates 4b (IC50 6.5 µM), 4j (IC50 5.5 µM) and 4g
(IC50 9.5 µM), against chloroquine sensitive Pf3D7 strain. Top fourteen molecules were screened
also against chloroquine resistant Pf INDO strain and the observed resistant indices were found to
lie between 1 and 7.58. Computational molecular docking studies indicated a unique mode of binding
of these quinolines to Falcipain-2 and heme moiety, indicating these to be the probable targets
of their antiplasmodial action.

Conclusion:

An important finding of our work is the fact that unlike Chloroquine which shows a
resistance Index of 15, the resistance indices for the most promising molecules studied by us were
about one indicating equal potency against drug sensitive and resistant strains of the malaria parasite.
Elevated Expression of A-Raf and FA2H in Hepatocellular Carcinoma is Associated with Lipid Metabolism Dysregulation and Cancer Progression
Authors: Ranjpour Maryam , Wajid Saima , Jain Swatantra K.
Published: October 2018

Background:

Identification of events leading to hepatocellular carcinoma (HCC) progression is essential for understanding its pathophysiology. The aims of this study are to identify and characterize differentially expressed proteins in serum of HCC-bearing rats and the corresponding controls during cancer initiation, progression and tumorigenesis.

Methods:

Chemical carcinogens, N-Nitrosodiethylamine and 2-aminoacetylfluorine are administered to induce HCC to male Wistar rats. The 2D-Electrophoresis and PD-Quest analyses are performed to identify several differentially expressed proteins in serum of HCC-bearing animals. These proteins are further characterized by MALDI-TOF-MS/MS analyses. Using pathwaylinker a HCC-specific network is analyzed among the MALDITOF- MS/MS characterized proteins and their interactors.

Results:

Carcinogen administration caused inflammation leading to liver injury and HCC development. Liver inflammation was confirmed by increase in the levels of TNF-α and IL-6 in carcinogen treated rats. We report significant increase in expression of two differentially expressed proteins, namely, A-Raf and Fatty Acid 2- Hydroxylase (FA2H), at early stage of HCC initiation, during its progression and at tumor stage. Real-time PCR analysis of mRNA for these proteins confirmed up-regulation of their transcripts. Further, we validated our experimental data with sera of clinically confirmed liver cancer patients.

Conclusion:

The study suggests that FA2H and A-Raf play a major role in the progression of HCC.
Prevalence of Metallo-β-Lactamases in Acinetobacter Baumannii in Iran: A Review and Meta-Analysis
Authors: Mohammadpour Bashir , Rouhi Samaneh , Moradi Masoud , Ramazanzadeh Rashid , Saniyi Ebrahim , Zandi Sairan , Salimizand Himen
Published: October 2018

Acinetobacter baumannii (A. baumannii) is an important opportunistic pathogen that causes major public health concerns, especially in hospitalized patients due to acquisition of resistant genes. The aim of this study was to systematically review the published data on the prevalence and dispersion of metallo-β-lactamases (MBLs) genes in A. baumannii in different provinces of Iran and provide an overall prevalence rate using meta-analysis. All available national and international databanks from 2011 to 2017 were searched to find published studies. Quality of studies was assessed by STROBE. Due to the fact that a significant heterogeneity was observed, the random effects model was used to combine the results. Statistical analysis was performed by comprehensive meta-analysis (CMA) V2 software. Out of 78 articles, 28 were extracted based on certain inclusion and exclusion criteria. Most of the A. baumannii isolates were obtained from intensive care unit (ICU) ward of hospitals. Based on phenotypic and molecular detection tests, pooled prevalence of all MBLs was 58%, and blaVIM, blaIMP, and blaSPM-1 genes were estimated to be at 10.5, 6, and 5%, respectively. Based on the results, further attention should be given to report MBL genes in A. baumannii based on molecular detection rather than the phenotypic one. Furthermore, more effort should be focused on ICU sections in order to avoid the distribution of resistant genes.
Natural Antimicrobial Agents as an Alternative to Chemical Antimicrobials in the Safety and Preservation of Food Products
Authors: Gomes Joana , Barbosa Joana , Teixeira Paula
Published: October 2018

Background:

Microbiological quality of food is of utmost importance in the food industry, so the use of food additives is essential to reduce microbial loads, which may result in food spoilage and poisoning.

Objective:

This study aimed to test the antimicrobial activity of three natural compounds – chitosan, ethanolic extract of propolis, and nisin – against 15 Gram-positive bacteria, 15 Gram-negative bacteria and two fungi and, also, to compare it with the antimicrobial activity of the chemical compound sodium nitrite, alone and in combination with sodium chloride.

Methods:

Antimicrobial activity was tested at different pH values and temperatures of incubation to simulate the presence of the pathogens in different food products and different storage conditions, as well as to determine their influence on the inhibition of microorganisms.

Results:

Most of the Gram-positive bacteria were inhibited at 25 µg/mL of nisin. Concentrations of 10 mg/mL of ethanolic extract of propolis inhibited fungi, most of the Gram-positive and some Gramnegative bacteria, and with concentrations of 0.65% (w/v) of chitosan, it was possible to inhibit most of the tested microorganisms. All the natural compounds tested had greater inhibitory effect against the various microorganisms compared with sodium nitrite alone and in combination with sodium chloride, in the different conditions of pH and temperature.

Conclusion:

This suggests that natural compounds could be good candidates for use as an alternative to chemical antimicrobials in food safety and preservation.
PEG Acoustic Levitation Treatment for Historic Wood Preservation Investigated by Means of FTIR Spectroscopy and Wavelets
Authors: Caccamo Maria T. , Cannuli Antonio
Published: October 2018

Background:

The combination of Fourier Transform InfraRed and levitation techniques,
both on levitated water mixtures of Polyethylene Glycols (PEG)s and on wood finds, allows to follow
the polymeric drying process as a function of time through the O-H and C-H stretching contributions
and to investigate the wood thermal response.

Objective:

The aim of this paper is to report the FTIR investigations on wood fines, extracted from a
700’ dated wooden crucifix.

Methods:

At first, different acoustically levitated Polyethylene Glycol (PEG) aqueous solutions were
investigated by FTIR in order to characterize the levitation induced dehydration process; then the wood
fines, after having been treated by immerging them into the PEG aqueous solutions, were acoustically
levitated and investigated; finally the treated fines were again studied by IR spectroscopy through a
thermic cycle in the 25 ÷ 350 °C temperature range. Levitation technique furnishes an innovative approach
to sample treatment allowing, in the case of solutions, to obtain highly concentrated mixtures
starting from diluted solutions while, in the case of wood find treatments, to increase the polymer solution
penetration within the wood matrix.

Results:

It clearly emerges that, in the PEG200/PEG600 comparison, the lighter polymer shows a higher
effectiveness in terms of thermal restraint.

Conclusion:

Acoustic levitation, in combination with IR spectroscopy, reveals to be a very powerful
technique in many applications concerning wood preservation and conservation. It clearly emerges that,
in the comparison with PEG600, PEG200 shows a higher effectiveness in terms of thermal restraint.
Pengembangan e-learning berbasis moodle dalam peningkatkan pemahaman lagu pada pembelajaran bahasa inggris
Authors: Irawan Randy , Surjono Herman Dwi
Published: October 2018

Penelitian ini bertujuan untuk: (1) menghasilkan produk e-learning bahasa Inggris berbasis Moodle  yang layak dalam peningkatan listening skill pada pembelajaran bahasa Inggris untuk SMK Negeri 4 Yogyakarta (2) mengetahui seberapa efektif e-learning berbasis Moodle terhadap listening skill pembelajaran bahasa Inggris siswa kelas X SMK Negeri 4 Yogyakarta. Jenis penelitian ini adalah R & D atau research and development menggunakan model Alessi & Trollip melalui tiga langkah berikut: planning, design, dan development. Subjek Penelitian ini adalah siswa SMK Negeri 4 Yogyakarta. Tenik pengumpulan data yang digunakan yaitu wawancara, angket, dan tes. Hasil penelitian ini adalah sebagai berikut. (1) Produk e-learning dikembangkan dengan sebuah Learning Management System (LMS) online yang dibuat dengan software aplikasi Moodle versi 3.1.  (2) Produk e-learning berbasis Moodle telah memenuhi kriteria dan dinyatakan layak sebagai media pembelajaran berdasarkan validasi ahli media dengan skor 3,70 dengan kriteria “Baik”, berdasarkan validasi ahli materi dengan rerata skor 4,34 dengan kriteria “Sangat baik”, dan berdasarkan respon pengguna dengan skor 4,30 dengan kriteria “Sangat baik”. (3) Hasil belajar siswa kelas X UPW 2 SMK Negeri 4 Yogyakarta mengalami peningkatan setelah menggunakan e-learning. Keefektifan produk terhadap pembelajaran bahasa Inggris pada kompetensi listening dibuktikan melalui peningkatan hasil belajar yang diketahui dari persentase hasil evaluasi pretest dan posttest yakni sebesar 17,19%.Kata kunci: e-learning, listening, bahasa Inggris DEVELOPING  AN E-LEARNING PRODUCT BASED ON MOODLE FOR INCREASING  SONG COMPREHENSION IN TEACHING ENGLISHAbstractThis study aims to: (1) produce e-learning based on Moodle English viable in increasing listening skills in Teaching English for SMK Negeri 4 Yogyakarta (2) determine how effective E-learning based Moodle on listening skills in Teaching English for students class X SMK Negeri 4 Yogyakarta. The result are as follows. (1) The E-learning product was developed with a learning management system (LMS) online software applications created with Moodle version 3.1. (2) The e-learning based on Moodle is appropriate as a medium of learning based on the judgement from media experts with the feasibility mean score of 3.70 (good category), judgement from material experts with the feasibility mean score of 4.34 (very good category) and  judgement from user  with the feasibility mean score of 4.30 (very good category). (3) The learning achievement of class X UPW 2 students of SMK Negeri 4 Yogyakarta increases after the use of the e-learning product. The effectiveness of the product to learning English in listening competence demonstrated through learning outcome is known of the percentage of pretest and posttest evaluation results which amounted to 17.19%.Keywords: e-learning, listening, English
Pengembangan multimedia pembelajaran interaktif kimia berbasis android menggunakan prinsip mayer pada materi laju reaksi
Authors: Putri Dian Puspita Eka , Muhtadi Ali
Published: October 2018

Tujuan penelitian adalah(1) mengetahui karakteristik produk multimedia yang layak untuk materi laju reaksi (2) menguji keefektivan produk dalam meningkatkan capaian hasil belajar kognitif. Penelitian dilakukan di kelas XI IPA 3 SMAN 9 Yogyakarta. Metode penelitian R & D dari model Alessi and Trollip. Subjek uji  coba  adalah 3 ahli media dan 3 ahli materi pada uji alpha, 1 guru kimia dan 5 orang siswa pada uji beta, dan 30 siswa pada uji validasi. Pengumpulan data menggunakan observasi, wawancara, angket, dan tes.  Data dianalisis secara deskriptif kualitatif dan perhitungan statistik. Hasil penelitian: (1) produk sangat layak (2) karakteristiknya dapat memvisualisasikan konsep laju reaksi, tersusun atas beberapa jenis media penggunaan dikontrol siswa, memenuhi perbedaan kecepatan belajar, dan dikemas dalam bentuk aplikasi berbasis android. Oleh karena itu, pembelajaran dengan produk yang dihasilkan dapat dilakukan dimana saja dan kapan saja; (3) produk terbukti efektif dalam meningkatkan capaian hasil belajar kognitif pada materi laju reaksi.Kata kunci: multimedia pembelajaran interaktif, laju reaksi, capaian hasil belajar kognitif DEVELOPING INTERACTIVE MULTIMEDIA LEARNING CHEMISTRY BASED ON ANDROID WITH MAYER’S PRINCIPLES ON RATE REACTION COURSEAbstractThis study aims to: (1) determine the effectiveness of multimedia products interactive learning based on Android using the principles of Mayer viable in the material reaction rate. (2) test the effectiveness product to improve outcomes cognitive achievement of students in the material rate reaction. This research was conducted in SMAN 9 Yogyakarta by using research and development methods (R & D), followed the model Alessi and Trollip. Subject trials of investigational products were the three experts of media and three experts material on the alpha test, one chemistry teacher and 5 students grade XI students in beta test and 30 students of class XI IPA 3 SMAN 9 Yogyakarta on validity test the effectiveness of the product. The collection of data was done through observation, interviews, questionnaires, and tests. Data were analyzed by descriptive qualitative and statistical calculations. The results show: (1) the products considered to be feasible, (2) the product has characteristic can visualize the concept of reaction rate, composed of several types of media, the activity can be controlled by students, can meet the student's pace difference, can be installed on android smartphone can be done learn; (3) the product proved effective in raising the achievement of the cognitive learning.Keywords: multimedia interactive learning, rate reaction, cognitive learning outcomes
Pengembangan video pembelajaran bumbu dan rempah pada mata pelajaranpengolahan makanan kontinental
Authors: Demayanti Febria , Soenarto Sunaryo
Published: October 2018

Penelitian ini bertujuan: (1) menghasilkan materi video yang layak digunakan sebagai media pembelajaran bagi siswa SMK Jurusan Tata Boga secara umum, dan secara khusus untuk SMK Ma’Arif 2 Sleman. Materi video lebih menekankan pada pengenalan bumbu dan rempah kontinental (continental spice) pada mata pelajaran Pengolahan Makanan Kontinental; (2) mendokumentasikan beberapa bumbu dan rempah kontinental (continental spice) secara detail, meliputi: bentuk, sifat, karakter dan kegunaan bahan tersebut; (3) mengetahui manfaat penggunaan media video pembelajaran dalam meningkatkan hasil belajar siswa. Penelitian pengembangan ini merujuk 3 langkah yang dikembangkan antara lain: (a) praproduksi; (b) produksi; dan (c) pascaproduksi. Uji coba program video dilakukan 2 tahap yaitu skala kecil dan besar. Produk video yang telah direvisi digunakanuntuk pembelajaran PMK. Subjek tes sebelum dan sesudah pembelajaran menggunakan media video untuk mengetahui peningkatan hasil belajar. Pengumpulan data menggunakan teknik wawancara, observasi, dan angket. Teknik analisis menggunakan deskriptif. Validasi ahli materi dan ahli media hasilnya layak digunakan. Penilaian siswa tentang media video pembelajaran bumbu dan rempah kontinental rata-rata siswa memberi tanggapan “sangat layak” serta terdapat peningkatan hasil belajar siswa sesudah menggunakan program video pembelajaran.Kata kunci: video pembelajaran, bumbu dan rempah kontinental, hasil belajar DEVELOPING A VIDEO FOR THE LEARNING OF INGREDIENTS AND SPICES IN THE SUBJECT OF CONTINENTAL CUISINE PROCESSINGAbstractThis study aims to: (1) produce video materials appropriate to be used as learning media for students of Gastronomy in the vocational high school in general and in SMK Ma’arif 2 Sleman in particular; the video materials emphasize the introduction to continental ingredients and spices in the subject of Continental Cuisine Processing; (2) document several continental ingredients and spices in detail including their forms, nature, characters, and uses; and (3) investigate the benefits of the use of the learning video to improve students’ learning achievement. This was a research and development pouting 3 to the steps developed i.e.: (a) preproduction, (b) production, and (c) post-production. Video program testing is done in 2 to the steps; large & small scale. Revised video products are used for PMK learning. Tes subjects before and after learning using video media to the know the improvement of learning outcomes. The data were collected by interview technique, observation, and questioner. The analysis techniques were use descriptive. The results of the validation by the materials and media experts of the results is feasible to be used. The students’ assessment of the video for the learning of continental ingredients and spices show very appropriate responses on the average and there is an increase on the learning outcome after using the learning video program.Keywords: learning video, continental ingredients and spices, learning achievement
Pengembangan e-book interaktif mata pelajaran teknologi informasi dan komunikasi (TIK) untuk SMK kelas X
Authors: Fathoni Muhammad Ihsaan , Marpanaji Eko
Published: October 2018

Penelitian ini bertujuan untuk: (1) mendeskripsikan pengembangan produk media pembelajaran e-book interaktif TIK yang layak pada peserta didik kelas X SMK N 2 Yogyakarta, dan (2) mengetahui efektifitas produk media pembelajaran e-book interaktif TIK terhadap hasil belajar peserta didik kelas X SMK N 2 Yogyakarta.Penelitian pengembangan ini mengacu langkah yang dikembangkan oleh Alessi & Trollip. Prosedur pengembangan terdiri dari dari tiga fase, yaitu perencanaan, desain, dan pengembangan. Pengumpulan data dilakukan menggunakan lembar validasi produk untuk ahli media, lembar validasi produk untuk ahli materi, kuisioner untuk pengguna, dan tes hasil belajar. Teknik analisis data menggunakan teknik deskriptif kualitatif dan kuantitatif.Hasil penelitian menunjukkan bahwa media pembelajaran e-book interaktif TIK dinilai sangat baik yang diperoleh melalui uji alpha dan uji beta, sehingga layak digunakan sebagai sumber belajar peserta didik. Uji efektivitas menunjukkan bahwa penggunaan media pembelajaran e-book interaktif TIK lebih efektif daripada pembelajaran TIK biasa. Rerata N-gain antara kelas eksperimen dan kelas kontrol menunjukkan bahwa nilai nilai kelas eksperimen lebih tinggi daripada kelas kontrol dan berbeda secara signifikan.Kata kunci: TIK, e-book, interaktif DEVELOPING INTERACTIVE E-BOOK ON INFORMATION AND COMMUNICATION TECHNOLOGY (ICT) LESSON FOR  GRADE OF VOCATIONAL HIGH SCHOOLAbstractThis study aimed to: (1) describe the development of instructional media products based on appropriate ICT interactive e-book on students for  grade of SMK N 2 Yogyakarta, and (2) to know the effectiveness of ICT interactive e-book based learning e-book products on participants' learning outcomes for 10th grade of SMK N 2 Yogyakarta. This development research refers to the steps developed by Alessi & Trollip. The development procedure consisted of three phases, namely planning, design, and development. Data collection was performed using product validation sheets for media experts, product validation sheets for material experts, questionnaires for users, and learning result tests. The data analysis techniques used qualitative and quantitative descriptive techniques. The result of the research showed that ICT interactive e-book learning media was very good which was proved through alpha test and beta test, so it was suitable to be used as a learning resource for learners. The effectiveness test showed that the use of interactive ICT e-book learning media was more effective than regular ICT learning. The mean N-gain between the experimental class and the control class indicated that the value of the experiment class grade was higher than the control class and differed significantly.Keywords: ICT, e-book, interactive
Nature and Diffusion of Gynecologic Cancer–Related Misinformation on Social Media: Analysis of Tweets
Authors: Chen Liang , Wang Xiaohui , Peng Tai-Quan
Published: October 2018

Background

Over the last two decades, the incidence and mortality rates of gynecologic cancers have increased at a constant rate in China. Gynecologic cancers have become one of the most serious threats to women’s health in China. With the widespread use of social media, an increasing number of individuals have employed social media to produce, seek, and share cancer-related information. However, health information on social media is not always accurate. Health, and especially cancer-related, misinformation has been widely spread on social media, which can affect individuals’ attitudinal and behavioral responses to cancer.

Objective

The aim of this study was to examine the nature and diffusion of gynecologic cancer–related misinformation on Weibo, the Chinese equivalent of Twitter.

Methods

A total of 2691 tweets related to 2 gynecologic cancers—breast cancer and cervical cancer—posted on Weibo from June 2015 to June 2016 were extracted using the Python Web Crawler. Two medical school graduate students with expertise in gynecologic diseases were recruited to code the tweets to differentiate between true information and misinformation as well as to identify the types of falsehoods. The diffusion characteristics of gynecologic cancer–related misinformation were compared with those of the true information.

Results

While most of the gynecologic cancer–related tweets provided medically accurate information, approximately 30% of them were found to contain misinformation. Furthermore, it was found that tweets about cancer treatment contained a higher percentage of misinformation than prevention-related tweets. Nevertheless, the prevention-related misinformation diffused significantly more broadly and deeply than true information on social media.

Conclusions

The findings of this study suggest the need for controlling and reducing the cancer-related misinformation on social media with the efforts from both service providers and medical professionals. More specifically, it is important to correct falsehoods related to the prevention of gynecologic cancers on social media and increase individuals’ capacity to assess the veracity of Web-based information to curb the spread and thus minimize the consequences of cancer-related misinformation.
Infeksi Virus Peste de Petits Ruminants (PPR) pada Kambing dan Domba di Indonesia
Authors: Sendow Indrawati , Adjid Raden Mohamad Abdul
Published: October 2018

Peste des petits ruminants (PPR) merupakan salah satu penyakit virus pada kambing dan domba yang ditandai dengan peradangan pada saluran  pencernaan dan pernafasan. Penyakit ini masuk dalam “daftar penyakit” yang dibuat oleh OIE. Keberadaan penyakit ini di Indonesia belum pernah dilaporkan sehingga perlu dilakukan surveilan secara  serologis  pada kambing dan domba untuk mendapatkan informasi awal keberadaan antibodi terhadap virus PPR.    Sebanyak 680 sampel serum kambing dan domba yang berasal dari Rumah Potong Hewan (RPH) Jakarta dan pedagang/pengumpul kambing dan domba di  Jakarta pada tahun 2014 telah dikoleksi.  Hasil pengujian dengan uji kompetitif ELISA yang menggunakan antigen inaktif (recombinant nucleoprotein- NP), menunjukkan bahwa telah terdeteksi antibodi terhadap virus PPR  dengan prevalensi 0,2% pada kambing dan 1,7 % pada domba asal RPH Jakarta. .  Berdasarkan lokasi asal ternak yang masuk ke RPH Jakarta, prevalensi tertinggi diperoleh dari Indramayu (2,8%), Solo 0.75%. Serum yang positif, beberapa negatif dan dubius tersebut kemudian  diuji  untuk dikonfirmasi   di Australian Animal Health Laboratory (AAHL) menggunakan uji ELISA dan menunjukkan hasil yang konsisten yaitu tetap positif atau negatif. Selanjutnya dilakukan pengambilan sampel serum dari domba dan kambing di beberapa kabupaten Indramayu pada tahun 2016. Hasil menunjukkan bahwa seluruh sampel sebanyak 326 sera telah diuji dengan uji ELISA hasilnya negatif.  Hasil penelitian ini memperlihatkan bahwa infeksi PPR masih sangat rendah, namun hasil ini  dapat menunjukkan indikasi awal adanya infeksi PPR di Indonesia. Oleh karena itu, kewaspadaan terhadap meningkatnya kejadian  infeksi PPR di Indonesia perlu mendapat perhatian.
Karakteristik Fisik dan Kimia Telur Burung Mamoa (Eulipoa Wallacei) di Pantai Uwo Uwo Kecamatan Galela Kabupaten Halmahera Utara
Authors: Sapsuha Yusri , Sjafani Nur , Albaar Nurjana , Ishak Hasriani
Published: October 2018

The aim of this research was to determine physicochemical characteristics of Mamoa egg. The eggs were collected about 100 eggs from Uwo uwo beach. Physical quality was observe in Animal Husbandry laboratory, Faculty of Agricultural, Khairun University. The physical characteristics observed were measuring include weight, shape, colour of eggshell, length, diameter, egg index, albumen, yolk, weight of eggshell, haugh unit, and thickness of eggshell. The chemical characteristics consist of moisture content, protein, fat content, fiber content, ash, carbohydrate, cholesterol, and antioxidant. Data were analyzed by quantitative descriptive analysis. The result showed that physical quality of egg were weight = 97.28 g, length = 7.12 cm, diameter = 5.45 cm, index of egg = 71.89%, Percentage of yolk and albumen were 69.12% and 23.24%, haugh unit score = 68.78 and shape of egg was ovale. The chemical characteristic of egg chemical quality were protein content = 15.47%, fat content = 8.31%, carbohydrate = 25.52 %, cholesterol = 387.54 mg/100gr, and antioxidant = 49.08% dpph.
Pengaruh Ekstrak Buah Delima Terstandar 40% Ellagic Acid terhadap Profil Darah Tikus Putih Yang Mengalami Nefrotoksisitas akibat Induksi Gentamisin
Authors: Lukiswanto Bambang Sektiari , Yuniarti Wiwik Misaco
Published: October 2018

The purpose of this study was to determine the effect of pomegranate extract of 40% ellagic acid on blood profile of albino rats that had nephrotoxicity after included with Gentamicin. a total of 32 white rats were divided into four treatment groups, each consisting of eight rats. the four treatment groups were healthy rats (P0), Gentamicin induced rats (P1), Gentamicin induced rats and ellagic acid treatment (P2) and Gentamicin induced rats and standardized Pomegranate extract therapy 40% ellagic acid treatment (P3). After seven days of treatment, blood was taken for blood profile tests. The results showed that in the Gentamicin-induced group (P0), a decrease in blood profile allegedly caused by Gentamicin that could cause damage and impaired renal tubular function. Givibg ellagic acid and pomegranate extracts of 40% ellagic acid proved to improve the blood profile of Gentamicin induced rats. This is due to inhibition of renal damage and improved renal function due to antioxidant activity possessed by ellagic acid and pomegranate extract of standardized 40% ellagic acid.
Studi Distribusi Glukosa Transporter 4 pada Otot Skelet Ayam Kedu Cemani
Authors: Budipitojo Teguh , - Ariana , Pangestiningsih Tri Wahyu , Wijayanto Hery , Kusindarta Dwi Liliek , Musana Dewi Kania
Published: October 2018

Glucose transporter (GLUT 4) is glucose transporter protein regulated by insulin, found in adipose tissue and striated muscle (skeletal and cardiac muscle). Kedu cemani chicken is one of Indonesia endemic animal, found in Kedu, Temanggung regency, Central Java. This study was required to complete microscopic documentation of  Indonesia’s native biodiversity. The objective of this study was to clarify GLUT 4 distribution in skeletal muscle fibers of kedu cemani chicken by using avidin-biotin-peroxidase complex (ABC) immunohistochemistry method. This study was conducted by using pectorales major, biceps brachii, and biceps femoris muscle tissue from 5 kedu cemani chicken. The result showed that GLUT 4 immunoreactivity were detected in sarcolemma and myofibrils component of pectorales major, biceps brachii, and biceps femoris muscle tissue. Intensity of GLUT 4 immunorectivites increased from weak intensity in pectorales major muscle tissue, moderate intensity in biceps brachii muscle tissue, then strong intensity in biceps femoris muscle tissue. This result might motivate to further exploration about the other kedu cemani chicken specific features to complete microscopic  documentation of  Indonesia’s native biodiversity.
PANEL COINTEGRATION: LONG-RUN RELATIONSHIP BETWEEN INTERNET, ELECTRICITY CONSUMPTION AND ECONOMIC GROWTH. EVIDENCE FROM OECD COUNTRIES
Authors: Kirikkaleli Dervis , Sokri Abderrahmane , Candemir Mehmet , Murat Ertugrul Hasan
Published: October 2018

The linkage between electricity consumption, internet demand and economic growth is aimed to investigate in this study in 35 OECD countries for the period 1993-2014. Panel cointegration, Fully Modified Ordinary Least Squares (FMOLS), Dynamic Ordinary Least Squares (DOLS) and Dumitrescu-Hurlin causality tests were performed to capture the potential long-run and causal linkages among the three variables. The findings from the FMOLS and DOLS models indicate a positive linkage between electricity, internet demand and economic growth in the long-run. Results from the Dumitrescu-Hurlin causality confirm feedback causality between electricity consumption and internet demand and unilateral causality running from economic growth to electricity consumption.
To the Question of Developing an Information System for Processing Textual Information on the Basis of Semantic Groups
Authors: Mochenov S V , Vtyurin M V , Ahmetgaleev R R
Published: October 2018

Рассматривается информационный подход к анализу текста, основанный на разбиении предложения на составные части и выделении темы и ремы. Актуальность работы обосновывается необходимостью поиска и выделения полезной для пользователя информации, которую он мог бы использовать при выполнении необходимых научных исследований. Введено понятие структурно-семантических смысловых групп предложений и определены требования к ним. Смысловая группа предложения определяется на основе анализа связей между словами предложения и включает в себя некоторый набор рядом расположенных слов, задающих некоторый новый образ. Описан сценарий анализа текстовой информации на основе предлагаемого подхода. Приведено описание подходов при разбиении текста документа на смысловые группы. Приведены развернутые результаты работы программного комплекса при различной целевой установке на обработку текста. Представленные результаты показывают возможности разработанного программного комплекса: выполнение структуризации отдельных предложений текста; формирование ключевых слов в виде смысловых групп для дальнейшего анализа; отбор смысловых групп, определяющих основной смысл предложений и текста; значительное сокращение текста при сохранении смысловой составляющей. В дальнейшем предполагается расширение функциональных возможностей комплекса и проверка основных идей при обработке больших информационных массивов.
Kompensatsiya dreyfa tverdotel'nogo volnovogo giroskopa
Authors: Trutnev G A , Nazarov S B , Perevoschikov K K , Schenyatskii A V
Published: October 2018

Рассматривается твердотельный волновой гироскоп - измерительный прибор, работающий в режиме свободных колебаний. Из-за различных погрешностей искажается эффект Брайана, который лежит в основе работы прибора. Рассматриваются явления, искажающие эффект Брайана и ухудшающие точность прибора - собственный уход волны (дрейф), нелинейность выходного сигнала, шумы. Приводятся причины возникновения дрейфа и нелинейности. Формулируется общая задача и методика увеличения точности прибора за счет использования моделей дрейфа и нелинейности. Приводятся подходы к оценке значений скорости дрейфа волны и нелинейности выходного сигнала для обработки и получения параметров, которые в дальнейшем будут использоваться в работающем приборе для увеличения точности выходного сигнала. Изучаются факторы, влияющие на дрейф твердотельного волнового гироскопа. Приводятся различные существующие модели дрейфа. Описываются недостатки и особенности существующих моделей. Обосновывается необходимость учета в модели температурных влияний. Приводится зависимость резонансной частоты от температуры. Обосновывается возможность использования значений резонансной частоты в работающем приборе. Для оценки параметров дрейфа предлагается использовать модель двух переменных. Зависимость от углового положения волны аппроксимируется гармоническими функциями; зависимость дрейфа от резонансной частоты предлагается аппроксимировать с помощью сплайнов. Выводятся формулы для расчета параметров по результатам измерений дрейфа. Анализируются особенности предложенной модели. Модель может быть использована как для аппроксимации данных, так и для последующей компенсации погрешности в работающем приборе. Описывается возможность использования полученной модели для исследований зависимости дрейфа от скорости нагревания.