bluuebunny/crossref_metadata_2025 huggingface dataset:
Key Targets and Molecular Mechanisms of Active Volatile Components of
Rabdosia rubescens in Gastric Cancer Cells
Authors: Hu Yanhui , Cui Qingli , Ma Dongyang , Jin Wenwen , Li Yingyue , Zhang Jianhua , Xu Youqi
Published: October 2022

Objective:

To examine the effect and mechanism of volatile components of Rabdosia
rubescens on gastric cancer.

Methods:

Gas chromatography-mass spectrometry was used to detect and identify the volatile
components of R. rubescens. The network pharmacology method was used to analyze the targets
of volatile components of R. rubescens in gastric cancer and to reveal their molecular mechanisms.
The effects of volatile components of R. rubescens on gastric cancer cells were verified by biological
experiments.

Results:

Thirteen volatile components of R. rubescens were selected as pharmacologically active
components. The 13 active components had 83 targets in gastric cancer, and a Traditional Chinese
Medicine-component-targets gastric cancer network was successfully constructed. Five core targets
were obtained: TNF, IL1B, MMP9, PTGS2 and CECL8. The volatile components inhibited
the proliferation of gastric cancer cells in a concentration-dependent manner and promoted the
apoptosis of gastric cancer cells. The volatile components reduced the levels of TNF, IL1B, MPP9,
and PTGS2 in a concentration-dependent manner.

Conclusion:

Our study demonstrates the effects of volatile components in R. rubescens on gastric
cancer and provides preliminary findings on their mechanisms of action.
Trends and Application of Analytical Methods for the Identification and
Quantification of Dexamethasone in Drug Delivery System
Authors: da Silva Leite Joandra Maísa , Barros Araújo Camila Beatriz , Alves Larissa Pereira , Bezerra Pereira Milena Raissa , Guedes Gabryella Garcia , de Carvalho Moreira Lívia Maria Coelho , Rocha Beatriz Patrício , Borges Joyce Cordeiro , de Azevedo Eduardo Pereira , Alencar Fernandes Felipe Hugo , Oshiro Junior João Augusto , de Lima Damasceno Bolívar Ponciano Goulart
Published: October 2022

Background:

Dexamethasone (DEXA) is a potent synthetic corticosteroid derived
from the cyclopentanoperhydrophenanthrene nucleus known for its anti-inflammatory and immunosuppressive
activities. Due to its therapeutic effects, several analytical methods have been
used for its quantitative determination and physicochemical characterization, as well as for the
evaluation of pharmacological and toxicological properties.

Objective:

This review aimed to describe the principles and methods commonly used to identify
and quantify DEXA in drug delivery systems and biological samples. The methods herein discussed
are high-performance liquid chromatography, nuclear magnetic resonance, x-ray diffraction,
Fourier-transform infrared spectroscopy, differential scanning calorimetry, ultravioletvisible
spectrophotometry and thin layer chromatography.

Conclusion:

This review provided a wide variety of analytical methods that can be used for the
quantification and identification of drugs, providing scientists with great support during the development
of scientific research, as well as ensuring the quality of the manufacturing processes
as well as the resulting products. Therefore, the use of such analytical methods has become critical
throughout the process of developing pharmaceutical formulations containing DEXA.
Effect of Prebiotic Supplementation on Probiotic Viability and Physicochemical
Characteristics of Fermented Coconut Water with Bifidobacterium
longum
Authors: Jahajeeah Meghna , Choo Wee Sim
Published: October 2022

Background:

Probiotics and prebiotics are functional ingredients that provide health benefits to consumers but they are mainly incorporated in dairy products. Designing a non-dairy product in which probiotics and prebiotics would be incorporated would allow more consumers to benefit from their advantages.

Objective:

This study investigated the effect of supplementation of two different prebiotics, fructooligosaccharide (FOS) and inulin, on the viability of Bifidobacterium longum ATCC BAA-999 in coconut water.

Methods:

Two concentrations of prebiotics used were 1% and 2%. The physicochemical characteristics of fermented coconut water with B. longum for 9 h at 37oC and during refrigerated storage at 4oC for 2 weeks were analyzed. The viability of B. longum in fermented coconut water was maintained above the recommended therapeutic level (7 log CFU/mL) with or without supplementation with prebiotics.

Results:

Most distinct changes in colour (∆E > 3) occurred in fermented coconut water compared to unfermented coconut water. An increase in the total soluble solids was also observed in fermented coconut water with the increase in the concentration of prebiotics. There were no significant changes in the clarity, pH, and concentrations of shikimic and malic acids in the fermented coconut water with or without supplementation with prebiotics over the 2 weeks of storage. Acetic acid production was observed in the fermented coconut water with the highest acetic acid production in the fermented coconut water supplemented with 1% FOS after 2 weeks of storage.

Conclusion:

This study demonstrated the potential use of coconut water as a medium to produce a probiotic drink.
Prevalence and associated factors of diabetic nephropathy at Tikur Anbessa Comprehensive Specialized University Hospital, Addis Ababa, Ethiopia
Authors: Aberra Theodros , Feleke Yeweyenhareg , Tarekegn Getahun , Bikila Demere , Melesse Mehari
Published: October 2022

ntroduction: Given the global prevalence of diabetes, diabetic nephropathy and its consequences are among the major causes of morbidity and mortality in diabetic populations. However, the prevalence and determinants of diabetic nephropathy in Ethiopia are little studied, and were the main objectives of this study. Methods: A cross-sectional study design was followed among 340 randomly selected diabetic patients attending the national diabetes referral clinics at the diabetes centre of Tikur Anbessa Specialized Hospital, Addis Ababa, using an interviewer-administered structured questionnaire. A total of 340 patients were involved, of whom 200 (59%) were females and 256 (75%) had type 2 diabetes mellitus. Urine and blood samples were drawn from the study population and the corresponding biochemical analyses were conducted at the Ethiopian Public Health Research Institute. Results: The mean age of the participants was 51.6 years (range 18–94 years). The median duration of their diabetes was 11 years (range 1–40 years). Forty-eight pecent of the patients were hypertensive. Only half of the hypertensive cases (53%) were using angiotensin-converting enzyme inhibitors, either alone or in combination with other antihypertensive medicines. Eighty-two percent of the participants had poorly controlled diabetes, with glycated haemoglobin >7%. None was using Sodium-glucose cotransporter 2 (SGLT2) inhibitors or glucagon-like peptide agonists. Some (109, 32%) of the participants were diagnosed with diabetic nephropathy in addition to reduced estimated glomerular filtration rate and albuminuria. Age, dyslipidaemia, educational status, presence of diabetic retinopathy, and elevated triglyceride levels were found to be significant predictors of the condition (P < 0.05). Conclusions: Diabetic nephropathy was present in nearly one-third of the diabetics in the study population. The management of diabetes with renoprotective agents, such as renin–angiotensin–aldosterone system inhibitors and SGLT2 inhibitors, are likely to be very important in this context. Keywords: diabetes mellitus, nephropathy, end-stage kidney disease, CKD
Iron indices in adults with sickle cell nephropathy in Lagos, Nigeria
Authors: Orolu Muyideen , Maboyoje Monica O , Braimoh Rotimi W , Bello Babawale T , Amira Christiana O , Kushimo Oyewole , Anyanwu Roosevelt A
Published: October 2022

Introduction: Although several studies have explored iron indices in patients with sickle cell anaemia (SCA), there is a paucity of evidence regarding the iron status of patients with sickle cell nephropathy (SCN). This study evaluated the range of iron status of adult SCA patients with or without nephropathy in Lagos, Nigeria.Methods: This was a cross-sectional study performed at the Sickle Cell Clinic of the Lagos University TeachingHospital (LUTH). Patients who were aged 18–65 years were assessed for SCN by determining the albumin-to creatinine ratio (UACR) on a spot urine sample, and determining the estimated glomerular filtration rate, using the CKD–EPI formula, on a steady-state serum creatinine concentration. Iron indices including serum ferritin, serum iron and total iron-binding capacity (TIBC) were measured, and percentage transferrin saturation (TSAT) was calculated. Data were analysed with the Statistical Package for the Social Sciences (SPSS) version 23. Results: A total of 200 patients were included, of whom 119 had SCN. There were no statistically significantdifferences in iron indices in participants with or without SCN. The median serum ferritin and TSAT of patients with SCN were 265 ng/mL and 31.8%, respectively, while the values were 255 ng/mL and 33.5% in those without SCN, respectively. Few participants were noted to have iron overload based on ferritin and TSAT values, regardless of SCN diagnosis. Although not statistically significant, females tended to have higher ferritin and serum iron values compared to males, irrespective of the presence or absence of SCN; whereas females without SCN had statistically significant higher TSAT values compared to males without SCN (36.2 ± 15.0% and 28.8 ± 11.5%, P = 0.03).Conclusion: Although iron overload is common in patients with SCA, our findings indicate that patients with SCNmay require routine evaluation of iron indices because few were iron overloaded. For this reason, the evaluation of iron indices in patients with SCN should be individualised to guide the direction of care and improve clinicaloutcomes. Keywords: Iron, sickle cell, nephropathy
Acknowledgement to reviewers 2020 and 2021
Authors: Davids M Razeen
Published: October 2022

The editors of AJN wish to thank the colleagues who generously gave of their time and expertise to review manuscripts for us during 2020 and 2021. We greatly appreciate their contribution to the quality of the work that we publish.
A roadmap for kidney care in Africa: An analysis of International Society of Nephrology–Global Kidney Health Atlas Africa data describing current gaps and opportunities
Authors: Okpechi Ikechi , Niang Abdou , Hafez Mohammed , Ashuntantang Gloria , Zaidi Deenaz , Ye Feng , Abdu Aliyu , Asinobi Adanze , Balogun Rasheed , Chukwuonye Innocent , Diongole Hassane , Effa Emmanuel , Ekrikpo Udeme , Gouda Zaghloul , Hussaini Jibrin , Kaze Francois , Kilonzo Kajiru , Kalyesubula Robert , Kununa Amna , Makusidi Muhammad , Mbah Ikechukwu , McCullough Mignon , Mengistu Yewondwossen , Moloi Mothusi , Moturi George , Ndlovu Kwazi , Ngigi John , Nklandu Yannick , Ntarindwa Joseph , Okel Julius , Olanrewaju Timothy , Osafo Charlotte , Samuel-Okpechi Ugochi , Shigidi Mazin , Sumaili Ernest , Ulasi Ifeoma , Umeizudike Theophilus , Wearne Nicola , Jha Vivekanand , Levin Adeera , Johnson David , Bello Aminu
Published: October 2022

Delivery of kidney care in Africa is significantly constrained by various factors. In this review, we used International Society of Nephrology–Global Kidney Health Atlas (ISN–GKHA) data for Africa to address sub-regional differences in care delivery in the continent with focus on infrastructure, workforce, and the economic aspects of kidney care. Forty two African countries participated in the survey conducted in 2018. North Africa had the highest proportions of nephrologists [12.53 per million population (pmp)], nephrology trainees (2.19 pmp) and haemodialysis (HD) centres (8.58 pmp); whereas southern Africa had the highest proportions of peritoneal dialysis (PD) centres (0.89 pmp) and kidney transplant (KT) centres (0.29 pmp); West Africa had the greatest nephrology workforce shortages. The annual median costs of HD (US$22,731 [interquartile range (IQR): US$1,560–43,902]) and PD (US$34,165 [US$34,165–34,165]) were highest in Central Africa and only Algeria, Egypt and South Africa reported zero co-payment for all modalities of kidney replacement therapy in the public sector. Policies on chronic kidney disease and non-communicable diseases were scarcely available across all African sub-regions. The ISN–GKHA African data highlight a stark difference in kidney care measures between North and sub-Saharan Africa and also suggest the need for a more cohesive approach to policy formulations that support and protect patients with kidney disease in the continent, especially from the excessive costs associated with care. Using the World Health Organization (WHO) Global Action Plan for noncommunicable diseases, this paper proposes an African roadmap for optimal kidney care.
Enhancing students’ digital literacy at EFL classroom: Strategies of teachers and school administrators
Authors: Razak Hussien Mohamad , Abdul Razak Norizan , Krish Pramela
Published: October 2022

Promoting digital literacies is the apparent goal of an extensive array of educational initiatives in all educational contexts. However, very limited attention has been directed toward the strategies of promoting students’ digital literacies in the literature. Thus, this qualitative study aims to identify the strategies of EFL teachers and school administrators in promoting EFL students’ digital literacies to thrive in the new normal challenges. Semi-structured interviews with 6 EFL teachers and 6 school admins from the Arab international schools in Kuala Lumpur were gathered using a convenient sampling technique. The qualitative data were analysed and reported thematically. The findings of the study revealed that teachers reported four strategies to promote students’ digital literacy: motivating students, conducting training workshops, actual use of digital technologies in the classroom, and enhancing classroom digital infrastructure. Similarly, school admins reported four strategies: rising parents’ awareness towards the importance of digital technologies, training teachers and students, enhancing classroom infrastructure and redesigning the EFL classroom. These findings offer implications for policymakers and researchers, especially those interested in enhancing students’ digital literacies. The results require further urgent large-scale investigations to address the factors that currently constrain the promotion of digital technologies.
Life quality of students majoring in sports education and its comparison with other students
Authors: Hendrayana Yudy , Hidayat Yusuf , Tresnadiani Dini , Hambali Burhan
Published: October 2022

Since it encompasses all facets of life, including health, hope, job, family, environment, and other aspects of daily existence, quality of life is one of the most important factors that may be categorized as a multidimensional term. However, each person's living circumstances might undoubtedly vary, which has an impact on how they perceive their quality of life. This study uses a descriptive survey method to investigate how students who undergo sports education and those who don't see their quality of life differently. It involved purposively selected 245 sports education students and 135 non-sports education students registered as active students admitted in the academic year of 2016-2019 in five (5) universities in Indonesia. All data, collected by using the WHOQOL-BREF quality of life scale, were quantitatively analyzed through the independent sample t-test. The results of the analysis likely prove that, in general, most students perceive a relatively good quality of life though there are differences in the quality of life between both groups. Students majoring in sports, however, have a better perception of quality of life than do non-sports education learners.
Effect of the problem-based adolescent reproductive health module on students’ life skills and attitudes
Authors: Citrawathi Desak Made , Abu Bakar Abu Yazid , Adnyana Putu Budi , Widiyanti Ni Luh Putu Manik , Sudiana I Ketut
Published: October 2022

This study aimed to analyze the effect of the implementation of a problem-based adolescent reproductive health module on students’ life skills and positive attitudes toward reproductive health. It was quasi-experimental research by applying a randomized pretest-posttest control group design, involving junior high school students who were divided into two groups, namely experimental and control groups. The data collection was conducted by using a life skills test and an attitude scale questionnaire as instruments. The instrument validity was tested by applying the Lawshe formula. The instrument’s reliability was tested using the Alpha-Cronbach formula. Multivariate Analysis of Variance was used to analyze the data collected. The research results indicated that learning by using a problem-based adolescent reproductive health module had a positive impact on the students' life skills and attitudes toward their reproductive health. Learning about the human reproductive system by using the module motivates the students to search for answers to the questions given at the beginning of the material. Based on those findings, learning using this module is recommended as one program to teach students (adolescents) education on reproductive health.
Professional development program for physical education teachers in Indonesia
Authors: Mu'arifin Mu'arifin , Narmaditya Bagus Shandy
Published: October 2022

Enhancing the quality of teachers has been a global challenge, and the government responded to this issue by providing various programs for teachers’ capacity upgrading This study aims at designing a professional development program for teachers of sports and health physical education in Indonesia. Using a research and development approach of Borg and Gall model, the study is to obtain comprehensive results and an understanding of the program. The preliminary findings indicate that the teachers face some obstacles in providing teaching and learning activities, although they have followed some coaching programs. The program development, therefore. proposed in this study consists of three primary documents: initiated program design, implementation guidelines, and evaluation prescription. Judgment by experts, principals, and teachers indicated that the program was proven valid, practical, and effective to be used as an assistance model for the professional development of sports and health physical education teachers in primary schools. The practical and managerial implications are also provided in this writing.
Analysis of confirmatory factors of principals' leadership training of vocational high school
Authors: Yuliana Lia , Prasojo Lantip Diat , Akalili Awanis
Published: October 2022

One of the main problems in the course of management in Vocational High School is the principal's leadership training problem. Great leadership training has an impact on improving the quality of schools, the quality of teachers, and the professionalism of teachers in carrying out educational activities. This research aimed to find out what is the result of Confirmatory Factor Analysis (CFA) on leadership training indicators for the principals of Vocational High School based on the perception of teachers, principals, and students. The method used in this research is a quantitative method to find out the result of Confirmatory Factor Analysis leadership training for principals of Vocational High School. This research used a simple random sampling technique with 255 teachers, 57 principals, and 315 students as the sample. The data analysis applied is KMO (Keiser-Meyer-Olkin Measure of Sampling Adequacy) and Bartlett’s Test of Sphericity. Extraction Method with Principal Component Analysis. The result of the study shows that the teacher sample obtained the KMO value 0,737 which indicates sample suitability is high (0,5), and the lowest value of MSA (Measure of Sampling Adequacy) is 0,550. Meanwhile, the highest is 0,852, communalities value and appropriate matrix components, loading factor on all variables have met the requirements above 0,40, and all factors on the leadership training instruments for the principal of Vocational High School have an AVE value greater than 0,5; thus, they have met reliability and can be accepted. The principal sample obtained the KMO value of 0,738, and the lowest value of MSA (Measure of Sampling Adequacy) is 0,556. The highest is 0,859 indicating communalities value appropriate matrix components. Loading factors on all variables are above 0,40, and all factors on the leadership training instruments for the principal of Vocational High School have an AVE value greater than 0,5. The student sample obtained the KMO value is 0,682, the lowest value of MSA (Measure of Sampling Adequacy) is 0,556 and the highest is 0,859; communalities value and appropriate matrix components, loading factor on all variables are above 0,40, and all factors on the leadership training instruments for the principal of Vocational High School have an AVE value greater than 0,5. Thus, they have met reliability and can be accepted.
A thematic analysis of teachers’ experience in teaching inclusive physical education
Authors: Suryobroto Agus Sumhendartin , Setiawan Caly , Nampai Udon , Dwi Marhaendro Agus Susworo
Published: October 2022

The current research aimed at investigating physical education teachers’ experiences in practicing inclusive physical education and the meaning they attached to those experiences. The study focused on the thematic analysis of participants’ experiences represented in the collected qualitative data. A number of 12 physical education teachers participated in in-depth interviews and photo elicitation interviews. Verbatim transcripts were obtained from all interviews for subsequent analysis. Using the tenets of thematic analysis (Braun Clarke, 2006, 2019, 2021), analysis included familiarization with the data, open coding, theme construction, theme review, theme naming, and report production. The analysis process yielded four themes of teachers’ experiences including (1) the roles of background knowledge and skills, (2) teaching various types of disabilities, (3) inclusive pedagogy approaches, (3) facilitators and barriers to teaching inclusive physical education. The meaning of the experiences were the meaning of inclusion, inclusive physical education, and inclusive physical education teaching. We conclude that experience is important in delivering inclusive PE, especially with regard to teachers’ development in the area of pedagogical knowledge and skills as well as dealing with challenges in their teaching approaches. Along with this experience is the meaning of teaching inclusive PE which reflected in-depth engagement with this caring profession.
Feasibility of Structured Assignment Sheet to Train The Ability to Draft a Frame of Mind in Solving Chemical Problems in Reaction Rate Materials
Authors: Janah N. R. , Suyono S.
Published: October 2022

The study aimed to produce a feasible structured assignment sheet as a learning device. The structured assignment sheet was feasible to be used to train the ability to draft a frame of mind in solving chemical problems in reaction rate material. This developed learning device is named SAS-ADFM. The feasibility of SAS-ADFM included criteria of validity, practicality, and effectiveness. SAS-ADFM was developed using the Research and Development (RD) method. SAS-ADFM was tested on 15 students of class XI who had obtained reaction rate material at SMAN 3 Surabaya. The instruments were the sheets of validation, student response questionnaire, and frame of mind drafting ability test. The validity of SAS-ADFM based on the assessment of three validators met the criteria of validity with a value of Mo ≥ 4 and R ≥ 75%. Meanwhile, the practicality of SAS-ADFM based on the analysis of the assessment of the student response questionnaire produced a very practical category with a percentage of 99%. Finally, the effectiveness of SAS-ADFM based on the analysis of the assessment of the ability to draft a frame of mind produced an N-gain score of 0.5 with a medium category. Hence, the developed SAS-ADFM was feasible to be used as a learning device.
Does an Android-Based Interactive Flipbook Affect the Student’s Science Concept Mastery?
Authors: Nisa W. M. , Tyas R. A.
Published: October 2022

This study aims to determine the effect of using android-based interactive flipbook media in increasing the mastery of science concepts for junior high school students. The research was conducted in one experimental class and one control class at SMP Negeri 2 Genteng, Banyuwangi. The instruments used were 10 multiple choice questions and 3 essay question with cognitive levels of C1 – C6. The method used is a Quasy Experiment with a pretest posttest control group design. The experimental class and control class were taken by simple random sampling. The data analysis technique used is the analysis of the independent sample T test with the help of SPSS application and the standard gain value using the gain equation. Sig value. (2-tailed) independent sample T test is 0.000, this indicates that there is a significant didfference between the average concept matery of student in the experimental class and control class. Gain value shows that the average mastery of the concepts of experimental class student has increased from before and after treatment of 0.66 with moderate criteria. The average concept mastery of control class students increased from before and after treatment by 0.24 with low criteria.
Bribery in business sector: Vietnam's regulation and current situation
Authors:   Faculty of Law, University of People's Security, Ho Chi Minh City, Vietnam, Hung Vu Van , Dung Nguyen Duy ,   Faculty of Law, Nguyen Tat Thanh University, Ho Chi Minh City, Vietnam
Published: October 2022

Corruption is a negative phenomenon appearing in many subjects of society. In Vietnam’s business sector, the most common form of corruption is bribery. Bribery to falsify business activities undermines development, and innovation reduces labor productivity and hinders the correct policies of the Government. In recent years, Vietnam’s economy has been developing rapidly. However, besides the economic development, Vietnam is facing many problems in business, such as bribery, which is considered an "inevitable" issue when doing business in Vietnam. Previous studies have focused on bribery in Vietnam. However, most researchers are concerned with the consequences of bribery, the effects of bribery on socio-economic, and the Government anti-corruption policy. There is no in-depth research to analyze the legal framework and clarify the situation in a narrow field such as bribery in business in Vietnam. Our study will evaluate Vietnam's regulations on anti-bribery in business and analyze the current practice of this problem, which focuses on clarifying the situation of enterprises bribing officials and assesses the extent of the act of bribery, thereby providing a general overview of bribery in business in Vietnam.
An Analysis of the Principles of Sustainable Income based on Kitab al-Kasb
Authors: Jaapar Nurzahidah , Mohamed Yusof Mohd Faiz , Syed Abdullah Sharifah Fadylawaty , Abdul Halim Anis Husna
Published: October 2022

This article aims to analyze the principles of sustainable income according to Islam based on the writings of Imam al-Syaibani in Al-Kasb. He highlighted the principles of responsibility and trust in seeking income, the appreciation of the concept of tawakkal and the priority of earning a living. This study is qualitative, using content analysis methods to extract some of the themes mentioned above. The study found book Al-Kasb is an injection of Islamic economic thought that encourages the practice of sustainable wealth management by al-Shaybani to respond to economic problems involving Muslims.
Keywords: Al-Kasb, Al-Shaybani, Sustainable wealth management.
eISSN: 2398-4287 © 2021. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI:
Implementation of educational technologies in the process of teaching hospital therapy
Authors: Ponomareva E. Yu. , Rebrov A. P.
Published: October 2022

The article discusses the concept of “technology” in the educational process, the role of technology in higher medical education; presents the implementation of some educational technologies used in higher medical education, in the process of teaching hospital therapy. In the article, the authors consider the situational task as a kind of “case technology” in teaching hospital therapy.
Markable coagulopathy in the patient with severe COVID-19
Authors: Roshchina A. A. , Yupatova M. I. , Nikitina N. M.
Published: October 2022

The variative coagulation abnormalities with thrombotic and microvascular complications are distinguishing feature of the severe new coronavirus infection (COVID-19) pathogenesis. Abnormal coagulopathy is directly related to the risk of death in COVID-19 patients. In many patients with COVID-19, hemostasis disorders have been observed, which increase the risk of developing DIC (disseminated intravascular coagulation), thrombotic microangiopathy or antiphospholipid syndrome as a result of the pathogenetic factors combination: inflammatory response, endothelial dysfunction, increased platelet consumption, microvascular thrombosis. The mechanism of coagulopathy associated with COVID is still being found, COVID-associated coagulopathy exemplifies the potentiating multi-factor interactions between the immune system and the coagulation. We’re reporting a fatal case of 51-year-old male with COVID-19, complicated by severe acute respiratory syndrome (SARS) and severe thrombocytopenia, markedly enhanced fibrinolytic activity with skin-hemorrhagic syndrome, thrombotic complication (myocardial infarction), probably related to the DIC. This case demonstrates the need more basic and clinical research is warranted to further our understanding of the role of coagulation disorders mechanism in COVID-19 to prevent severe outcomes and mortality.
Energías renovables, PIB, mercados financieros e investigación: la experiencia de América latina. 2000-2019
Authors: Carreón Sosa Ricardo , Bonilla Vargas David
Published: October 2022

Las energías renovables deben ser parte del esfuerzo por alcanzar la reducción de emisiones de CO2 frente al calentamiento global. El objetivo general de esta investigación se enfoca en reconocer el impacto de agentes económicos, financieros y de I + D (Investigación y desarrollo) como factores de crecimiento en la generación de energía renovable (GER) en América latina (AL). La metodología se basa en un estudio econométrico que utiliza un análisis de panel con elementos fijos, se utilizan pruebas de especificación, (Ramsey) pruebas de autocorrelación (Durbin-Watson), (Breusch-Godfrey), y correcciones con (Cochrane-Orcutt). Los datos aportan resultados inéditos coherentes con los objetivos planteados, destacan la importancia de los mercados financieros como vía de impulso a los principales países en las seis tecnologías de GER, por lo cual se recomienda para AL acelerar el desarrollo de sus mercados e instituciones financieras y mayores inversiones en I+ D. Dentro de las conclusiones más importantes se reconocen en AL los efectos favorables reflejados en el sector bioenergético y el impacto positivo con el aumento del PIB en el crecimiento de la energía solar y eólica.
Персоніфікований енергомоніторинг та можливості його використання в періопераційному менеджменті в пацієнтів із грижею стравохідного отвору діафрагми
Authors: Cherniy V.I. , Denysenko A.I.
Published: October 2022

Актуальність. Актуальним є вивчення періопераційних змін метаболізму в пацієнтів при лапароскопічних хірургічних втручаннях у зв’язку з грижею стравохідного отвору діафрагми (ГСОД). Мета дослідження. Вивчити використання персоніфікованого енергомоніторингу пацієнтів із ГСОД та оцінити його можливості в періопераційному менеджменті. Матеріали та методи. Проспективне нерандомізоване дослідження: 132 пацієнти віком 32–77 років (чоловіків — 64, жінок — 68), яким проводилися лапароскопічні оперативні втручання, у зв’язку із ГСОД. Передопераційний ризик ASA II–ІІІ. Загальне знеболювання з використанням інгаляційного анестетика севофлюрану та наркотичного анальгетика фентанілу в умовах низькопотокової штучної вентиляції легенів. Операційний моніторинг був доповнений використанням непрямої калориметрії. У групі І (n = 66) визначався поточний метаболізм (ПМ) та базальний метаболізм (БМ) на фоні стандартної інтенсивної терапії. У групі ІІ (n = 66) додатково визначався цільовий метаболізм (ЦМ) та ступінь порушення метаболізму (СПМ = × 100 %), а інтенсивна терапія доповнена додатковою інфузійною терапією та глюкокортикоїдами з урахуванням ПМ, ЦМ та СПМ. Результати. Вихідні показники ПМ були без порушення і значно перевищували БМ (у групі І — на 30 %, у групі ІІ — на 29 %). На етапі зворотного положення Тренделенбурга, пневмоперитонеуму та початку операції в пацієнтів були суттєві порушення ПМ зі зниженням до БМ. У пацієнтів групи І повільне відновлення ПМ, який на момент пробудження був на 8,2 % нижчим від вихідного (р < 0,05). У пацієнтів групи ІІ на фоні посиленої інфузійної терапії та введення глюкокортикоїдів відновлення ПМ було більш інтенсивним зі зниженням СМП до безпечного рівня (5,4 ± 2,7 %), а ПМ — до вихідних значень (р < 0,05). Пацієнти групи ІІ швидше пробуджувалися та переводилися в палату, а нудота і блювання в них були в 2,2 раза рідшими, ніж у групі І (р < 0,05). Післяопераційний біль за ВАШ через 6 та 12 годин після пробудження у групі ІІ був нижчим на 29 та 35,5 %, ніж у групі І (р < 0,05). Висновки. Персоніфікований періопераційний енергомоніторинг робить більш безпечним проведення хірургічних втручань у пацієнтів із ГСОД. Додаткове визначення цільового метаболізму та ступеня порушення метаболізму дозволяє ефективніше будувати періопераційну інтенсивну терапію.
The Indigenous Politics of Justice: The Case of the Sedulur Sikep Movement in Central Java
Authors: Adam Ronald , Bagir Zainal Abidin
Published: October 2022

The struggle by indigenous people to protect their land from capitalist expansion is often reduced by scholars to two contrasting models: class politics and identity politics. This reduction has partially come from how scholars separate between the cultural/spiritual and the political-economic dimensions of these struggles, which are often more complex in reality. Based on an empirical study of the Sedulur Sikep movement in Pati, Central Java, the purpose of this article is to understand what the indigenous politics of justice looks like in practice as they defend their land and way of life against the cement mining industry. This study uses a qualitative approach combining four months of field observations with two Wong Sikep households and interviews with 20 Wong Sikep individuals from 15 households in Baturejo Sukolilo Village, Pati Regency, Central Java. This article discusses two findings from the study. First, the cultural/spiritual and political-economic dimensions are inseparable in the lives of Wong Sikep. Such inseparability is manifested through the agricultural system as the core of Wong Sikep life, derived from the teachings of their ancestors (culture/spirituality) as well as their practical needs (political economy). Second, this inseparability forms the basis of their adoption of both the politics of recognition and redistribution in their resistance to cement mining. The article concludes with recommendations for future studies about the Sedulur Sikep movement in particular and for indigenous justice movements more broadly.
Pengaruh Islam dan Eropa dalam Budaya Kuliner di Keraton Yogyakarta dan Surakarta Abad 19 dan 20 Masehi
Authors: Thohir Ajid , Azhara Bambang Muhamad Fasya
Published: October 2022

Islam and Europe are an integral part of the life of Keraton Yogyakarta and Surakarta, especially in the culinary culture of the keraton. This      study aims to identify      of the influence of Islam and Europe on culinary cultures at keraton yogyakarta and surkarta in the 19-20 centuries c.e., as well as the forms resulting from that influence. T     he research methods used      historical research methods, which refer to      various      sources categorized       into primary and secondary sources. The p     rimary sources include photo archives, newspapers, to invitation cards. As for secondary sources it is made up of books and articles. The results of this research identify what is h     alal or      lawful      and haram or       prohibited in the culinary culture. The keraton thus attempted to modify a variety of European dishes to be enjoyed without       violating      islamic teachings. As for the European influence, the rijsttafel, the orchestra, the ingredients used, to the use of a foreign language on the dinner table. Such European influence arose because of the process of interaction between Javanese nobles and europeans, the keraton attempted to imitate European customs.
Perundungan di Dunia Maya sebagai Perilaku Menyimpang: Analisis Isi Komentar dalam Konten Youtube Keke Bukan Boneka pada Kanal Rahmawati Kekeyi Putri Cantikka
Authors: Prayoga Reza Amarta
Published: October 2022

The comment column as an expressive forum on YouTube video sharing media is often used as a ground by netizens to stab comments - comments about "bullying cattle". Killing personal characters, dropping people's dignity, and negative comments tend to be rude, becoming decorations that are easily found and accessed in the comments column on YouTube. This paper specifically describes the behavior of netizens in bullying on Rahmawati Kekeyi Putri Cantikka's youtube channel on the content of the song Keke Bukan Boneka. The method used is descriptive qualitative. The form of data presented in this study is commented (responses or reviews) from citizens contained in the youtube channel. The presentation of the data analysis network in the form of comments using an online application, namely https://netlytic.org, and interpreted based on the theory of cyberbullying behavior proposed by Willard and the theory of deviant behavior from the combination of perspectives of James Vender Zender, Bruce J Cohen, and Robert M.Z. Lawang. The results of this study show that first, the content of the song Keke Bukan Boneka is used as an arena decorated with flaming, harassment, and denigration-type bullying comments on the figure of Kekeyi and trapped in a vortex of deviant behavior. Second, the network of bullying accounts is involved in enlivening the comment column, allegedly as a way to go viral the content of the song. Third, behind the exploitation that accompanied the bullying of Kekeyi, it turned out to be a commodity object to get monetization in the form of fantastic income from YouTube.
Persepsi Risiko Bencana Pada Mahasiswa di Kota Padang Ditinjau dari Pengalaman dan Variabel Demografis
Authors: Ruddin Fajar , Nurhabibi Pratiwi , Saputra Boni
Published: October 2022

Padang merupakan salah satu kota dengan ancaman bencana gempabumi dan tsunami. Kondisi tersebut dapat mempengaruhi persepsi risiko bencana penduduknya. Penelitian ini bertujuan untuk mengetahui persepsi risiko bencana gempabumi dan tsunami pada mahasiswa ditinjau dari pengalaman menghadapi bencana dan variabel demografis (gender, angkatan, rumpun pendidikan, dan jarak tempat tinggal). Penelitian ini menggunakan metode penelitian deskriptif dengan pendekatan kuantitatif. Subjek terdiri dari 213 mahasiswa Universitas Negeri Padang dari 8 fakultas yang berbeda yang dipilih dengan teknik cluster sampling. Skala yang digunakan adalah skala persepsi risiko bencana yang disusun berdasarkan model semantik diferensial. Hasil analisis data menunjukkan bahwa: (1) subjek memiliki tingkat persepsi risiko bencana yang tinggi; (2) tidak ada perbedaan persepsi risiko antara subjek yang pernah mengalami bencana dan belum pernah; (3) ada perbedaan persepsi risiko ditinjau dari variabel demografis meliputi gender, angkatan, dan rumpun pendidikan, sedangkan jarak tempat tinggal tidak ditemukan adanya perbedaan. Implikasi untuk memahami temuan dari penelitian ini didiskusikan dalam pembahasan.
Technology Negotiation in Dangdut Koplo’s Ecosystem and Practices
Authors: Raditya Michael H. B.
Published: October 2022

This article deals with the negotiation between the subgenre of Dangdut and technology. In this article, I articulate how agents of Dangdut Koplo use digital technology and how digital technology affects Dangdut Koplo’s ecosystem, cultural, and social practices. It is necessary to discuss Dangdut Koplo because it has several practices that are impacted by technology. Their practices elaborate on how society negotiated the use of technology. Dangdut koplo is one of the regional dangdut (dangdut daerah) subgenres that has developed in Indonesia, particularly East Java. Dangdut koplo emerged in the 1990s in Jarak Street, Surabaya, East Java. Furthermore, I will refer to two moments that demonstrated the impact of technology on the subgenre: first, the local people's activation of the local recording industry, and second, the activation of the internet and digital platforms by local people. I will elaborate on these to show the negotiation pattern between technology and their music, Dangdut Koplo. At the first moment, technological advances made people develop their local industries. The existence of local industries changed their economic and cultural patterns. Furthermore, middlemen in the music industry that Jakarta previously monopolized shifted to their surroundings. As a result, they could activate and directly control their economy and society. Then, the first moment developed rapidly in the second moment, when the internet changed society's social, economic, and cultural patterns. The internet allowed everyone to distribute their work. They could directly access consumers without the role of the previous middleman. Melayu Orchestra does not need a local music label or distributor with a solid fan base. They could distribute their works on the internet and digital platforms. This technological impact meant the Melayu Orchestra could compete with the local recording industry and vice versa. This pattern also changed their production processes, where digital needs made daily impressions, the development of Melayu orchestra personas on gadget screens, etc. Based on these developments, I elaborated on these questions: How did the ecosystem changes and its relationships impact the dangdut community? How is the dangdut community negotiating with technology? Utilizing digital data and observation data (obtained in 2017), I articulate how technological developments changed society's ecosystem and practice; and how society deals with technology.
The Immune System and Idiopathic Nephrotic Syndrome
Authors: Campbell Ruth E. , Thurman Joshua M.
Published: October 2022

Idiopathic nephrotic syndrome often responds to immunosuppressive treatment. Nevertheless, this syndrome—and the drugs used to treat it—remain important causes of patient morbidity. Idiopathic nephrotic syndrome is usually caused by minimal change disease or FSGS, diseases that primarily affect the podocytes. In spite of decades of research, the underlying causes of both diseases remain incompletely understood. There is, however, a large body of observational and experimental data linking the immune system with both minimal change disease and FSGS, including associations with systemic infections and hematologic malignancies. Perhaps most compellingly, many different immunomodulatory drugs are effective for treating idiopathic nephrotic syndrome, including biologic agents that have well-defined immune targets. In fact, the unexpected efficacy of targeted therapeutic agents has provided important new insights into the pathogenesis of these diseases. Given the large number of drugs that are available to deplete or block specific cells and molecules within the immune system, a better understanding of the immunologic causes of idiopathic nephrotic syndrome may lead to better diagnostic and therapeutic approaches.
Participatory evaluation practices in citizen social science: Insights from three case studies.
Authors:   ZSI - Centre for Social Innovation, Kieslinger Barbara , Schürz Stefanie , Mayer Katja , Schaefer Teresa
Published: October 2022

In citizen social science, citizens actively engage in research to investigate and solve challenges from their lifeworlds. As these interests are guiding the research process, we suggest employing a co-evaluation approach as a form of participatory evaluation that initiates the conversation on expectations and impact with the diverse actors involved from the onset. In the European funded research project CoAct, global social concerns such as youth employment, mental healthcare and environmental justice are addressed by three local research teams consisting of affected citizen groups, thematic and political stakeholders, and multidisciplinary academic researchers. The teams investigate and implement concrete actions and strategies to tackle these social challenges. In this contribution we reflect on first insights of co-evaluation from the three cases by applying a qualitative content analysis across different content formats, focusing primarily on the specific challenges and outcomes of citizen social science and co-evaluation. While the nature of the social issues at stake and the distinct socio-cultural contexts in which they are embedded clearly mark the boundaries of comparability, overall, a shift in roles and ownership across involved actors is observable. Identifiable intermediate outcomes are e.g. an increase in awareness, knowledge, and skills amongst stakeholders, which are in the long-term expected to increase empowerment, self-determination and the quality of life of the concerned participants, and lead to the implementation of new measures and regulations at policy level. With this work we want to contribute to the canonical development of citizen social science and generate productive feedback for the research process.
Documenting and assessing open innovation: co-creation of an open data model for surgical training
Authors:   Center for Science, Technology and Society, Drexel University, USA, Arancio Julieta , Velis Emilio , Torres Diego
Published: October 2022

Challenge competitions have recently resurged for promoting open innovation in areas where markets fail to provide incentives, such as the Sustainable Development Goals (SDGs). Challenges call for the general public to contribute novel solutions to a well-defined problem, in exchange for prizes, credentials and the promise of further development of selected solutions. The aim of this paper is to report on the development of an open and collaborative data model to document and evaluate innovations in the context of a challenge competition, while also being compatible with the work of other open source communities to validate and improve them. By reusing open documentation standards and embedding them into a semantic collaborative platform, the model aimed to be flexible enough to respond to the evaluation needs of the project organisers and self-assessment for participants. We expect our experience provides insights on the potential of semantic, collaborative platforms and standards for increasing the impact of innovations towards the SDGs.