bluuebunny/crossref_metadata_2025 huggingface dataset:
REVISÃO SISTEMÁTICA DAS INTERVENÇÕES BARIÁTRICAS E CIRURGIAS DO APARELHO DIGESTIVO: AVALIAÇÃO COMPARATIVA DE EFICÁCIA, COMPLICAÇÕES E IMPACTO METABÓLICO
Authors: Rodrigues Bruna Braga , Rego Pablo Well do Amaral , Silva Raymara Thaise Amaral , Lana Sávio Cotta , Martins Karoline Petricio , De Carvalho Andressa Barros Tenório Nunes , Neves Lucas Mendes Fagundes , Da Silva Bruna Figueredo Valadão , Abreu Marcelo Brenno Pereira , Soares Maria Clara Oliveira de Melo , Vieira Ayla Nunes , Saraiva Brenda Torres , Figueiredo Vitor Habib , Vanderley Sheylla Palmira Pereira , Garcia Denys Leandro Viana , Beserra Olívia Nathália Paulino
Published: February 2024

A cirurgia bariátrica emerge como uma alternativa considerada para aqueles que enfrentam dificuldades persistentes na gestão do peso por meio de abordagens convencionais, como dieta e exercício físico. A cirurgia bariátrica não é apenas uma intervenção física, mas também uma transformação significativa na vida dos indivíduos que a escolhem como uma medida para lidar com a obesidade. A metodologia empregada nesta revisão sistemática das intervenções bariátricas e cirurgias do aparelho digestivo teve como ponto de partida a busca por informações relevantes na plataforma PubMed. Os descritores Mesh específicos utilizados foram "Bariatric Surgery", "Surgical Procedures, Operative" e "Drug Therapy", visando abranger aspectos cirúrgicos e farmacológicos relacionados às intervenções. Todos os trabalhos dos últimos 5 anos. A análise dos artigos revelou resultados heterogêneos e interessantes. Cada estudo abordou distintos aspectos relacionados à cirurgia bariátrica, gerando uma variedade de conclusões e insights valiosos. Essa diversidade de perspectivas contribui para uma compreensão mais abrangente dos desdobramentos clínicos, impactos metabólicos e considerações terapêuticas associadas à cirurgia bariátrica. Em resumo, a cirurgia bariátrica representa uma alternativa para aqueles que enfrentam desafios significativos no controle da obesidade por meio de abordagens convencionais.
PRÁTICAS INTEGRATIVAS E COMPLEMENTARES NA SAÚDE DA MULHER: UMA POSSIBILIDADE DE CUIDAR
Authors: Cavalcante Wanessa Toscano , Da Silva Erlaine Souza , Giuliani Carla Denari , Lemos Sílvia Niedja de Sousa Farias , Dos Santos Virginia Grasiele Silva , Da Silva Juçara Elke Lourenço , Ramalho Juliana Paiva Góes , De Meneses Uberlândia Islândia Barbosa Dantas , Santana Fabio Carvalho , De Moura-Ferreira Maria Cristina
Published: February 2024

O objetivo das Práticas Integrativas e Complementares em Saúde (PICS) é prestar um cuidado de maneira holística, sendo capaz de promover a saúde, e proporcionar um equilíbrio entre tecnologia, ciência e principalmente humanização. Na  saúde  da  mulher  as PICs  vêm  sendo  utilizadas,  nas  diversas  fases  da  vida, como durante o período gestacional e puerpério, também no estresse e ansiedade do dia a dia. Além destes, está sendo empregada no climatério e menopausa, que constituem o fim da fase reprodutiva  da  mulher  e  trazem  consigo  diversos  sintomas  que  prejudicam  sua  qualidade  de vida, entre outras. Esta terapêutica atua de forma a proporcionar conforto, trazer bem-estar às pacientes e principalmente alívio de sintomas biológicos.
Molecular genetic characterisation of Salem Black goats
Authors: Thilagam K , Ramamoorthi J , Sivaselvam S N , Karthickeyan S M K , Thanguraju P
Published: February 2024

The present investigation was carried out to study the genetic architecture of Salem Black goats, a distinct genetic group of goats in Tamil Nadu, which needs to be recognized as a breed. The genomic DNA samples from 50 unrelated Salem Black goats were evaluated with a panel of 21 microsatellite markers for genetic characterization. In these animals, the number of alleles ranged from 4 to 9 with a mean of 6.5 / locus. The sizes of alleles and their frequencies ranged from 74 to 206bp and from 0.0106 to 0.4642 respectively. Polymorphism information content ranged from 0.5710 to 0.8424 with a mean PIC of 0.7177. Except for four loci, the population was not in Hardy-Weinberg equilibrium. The observed heterozygosity ranged from 0.7804 to 1.0000 while the expected heterozygosity ranged from 0.6470 to 0.8541. The study revealed that there is high amount of genetic variation present in the population with the defined levels of heterosygosity and polymorphism information content. Hence, this distinct population of Salem Black goats could be recognized as a breed of goats in Tamil Nadu.
Experimental cage culture of snow trout, Schizothorax richardsonii (Gray) and golden mahseer, Tor putitora (Hamilton) fry and fingerling in a sub-Himalayan lake Bhimtal, India
Authors: Basade Yasmeen , Mohan Madan
Published: February 2024

Trials were conducted to ascertain the potential of cage culture in a sub- Himalayan lake for commercially important indigenous upland fishes. Growth performances of different grow-out stages, namely fry and fingerlings of snow trout, Schizothorax richardsonii and golden mahseer, Tor putitora were assessed for 3 months. Fishes were stocked @ 20 fish/ m3; one set of fishes (experimental) were fed a 40% crude protein (CP) extruded pelleted feed, while the other set (control) thrived on natural food present in the lake. Rate of survival, net weight gain, per cent weight gain, specific growth rate (SGR) and gross yield of snow trout and golden mahseer fry and fingerlings were significantly higher in experimental group compared to the control. Feed conversion ratio (FCR) was calculated only for the experimental groups. Thus, this simple practice offers the possibility of rearing fry and fingerlings of snow trout and golden mahseer in floating cages in the sub-Himalayan lakes by using extruded pelleted feed.
PENGARUH PENAMBAHAN VITERNA PLUS DENGAN DOSIS BERBEDA PADA PAKAN TERHADAP PERTUMBUHAN IKAN GURAME (Osphronemus Gouramy)
Authors: Supu Francis Asman , Hasim Hasim , Mulis Mulis
Published: February 2024

Ikan Gurame merupakan salah  satu jenis ikan  yang memiliki nilai ekonomis tinggi  dan  memiliki pertumbuhan yang lambat. Penilitian ini bertujuan untuk mengetahui  pengaruh  penambahan viterna plus terhadap pertumbuhan dan kelangsungan hidup ikan gurame. Penelitian ini dilaksanakan pada bulan April sampai Mei 2022. Metode yang digunkan adalah eksperimen  dengan rancangan acak lengkap (RAL) . penelitrian ini menggunakan 12 wadah akuarium  bervolume 15 liter. Hewan uji yaitu ikan gurame.  Ukuran panjang rata-rata 3,38 cm dan berat rata-rata 0,48 gram sebanyak  180 ekor  dengan padat penebaran 1 ekor/liter, dengan lama pemeliharaan 30 hari. Data yang diambil meliputi pertumbuhan dan kelangsungan hidup. Data yang diambil diolah menggunakan  Analisys Of Variance (ANOVA) . Hasil uji anova menunjukan bahwa  pengaruh  penambahan viterna plus terhadap pertumbuhan dan kelangsungan hidup ikan gurame tidak berpengaruh nyata.
PENAMBAHAN LIMBAH CAIR TAHU PADA MEDIA WALNE UNTUK PERTUMBUHAN SPIRULINA SP
Authors: Piu Nur Jihan Fareranty , Koniyo Yuniarti , Syamsuddin Syamsuddin
Published: February 2024

Pakan  alami  merupakan  salah satu  faktor  penting  yang  mempengaruhi keberhasilan usaha budidaya ikan. Sebagian besar pakan alami ikan adalah plankton yaitu fitoplankton dan zooplankton. Kandungan zat gizi pakan alami sangat menentukan pertumbuhan larva yang dipelihara. Plankton sebagai jasad pakan alami merupakan sumber protein, karbohidrat, lemak, vitamin, dan mineral sehingga dapat memenuhi kebutuhan nutrisi larva yang dipelihara (Sukardi & Winanto 2011). Salah satu jenis fitoplankton adalah Spirulina sp. yang sering digunakan sebagai pakan alami bagi zooplankton, Rotifer, larva oyster, kerang mutiara, Abalone, udang, kakap, kerapu dan lainnya (Isnansetyo dan Kurniastuty, 1995). Spirulina sp. memiliki bentuk tubuh yang menyerupai benang yang merupakan rangkaian sel yang berbentuk silinder dengan dinding sel yang tipis, berdiameter 1-12 pm. Filamen Spirulina sp. hidup berdiri sendiri dan dapat bergerak bebas. Penelitian ini bertujuan untuk mengetahui pengaruh penambahan limbah cair tahu pada media walne untuk pertumbuhan spirulina sp, serta mengetahui dosis terbaik pada media walne untuk pertumbuhan Spirulina sp. Metode yang digunakan adalah eksperimen dengan desain Rancangan Percobaan yaitu Rancangan Acak Lengkap yang terdiri atas 5 perlakuan  dan  3  kali  ulangan.  Perlakuan  yang  diberikan  1  ml/L  walne  dan ditambahkan dengan limbah cair tahu A (2.5%), B (3%), C (3.5%), D (4%) dan E(0%).  Hasil  analisis  ragam  (ANOVA)  menunjukkan  Penggunaan  penambahan limbah cair tahu pada media walne untuk pertumbuhan Spirulina sp. sangat berbeda nyata dan perlakuan yang terbaik didapatkan pada perlakuan E (0%) limbah cair tahu.
PENGARUH PEMBERIAN FERMENTASI AMPAS TAHU TERHADAP BIOMASSA CACING SUTRA (Tubifex sp.)
Authors: Molese Lastris T. , Mulis Mulis , Suherman Sutianto Pratama
Published: February 2024

Cacing sutra (Tubifex sp.) merupakan salah satu pakan alami yang dibutuhkan dalam pembenihan ikan khususnya pada fase larva, karena memiliki kandungan nutrisi yang baik untuk pertumbuhan larva. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian fermentasi ampas tahu terhadap biomassa cacing sutra. Penelitian ini dilaksanakan pada bulan juni 2022 sampai dengan bulan juli 2022.Penelitian ini dilaksanakan selama 30 hari dan bertempat di Balai Perikanan Budidaya Air Tawar (BPBAT) Tatelu, di Desa Tatelu, Kecamatan Dimembe, Kabupaten Minahasa Utara, Provinsi Sulawesi Utara. Metode yang digunakan adalah eksperimen dengan Rancangan Acak Lengkap (RAL) yang terdiri dari 4 perlakuan dan masing-masing 3 kali ulangan. Perlakuan A (ampas tahu 30 g/wadah), B (ampas tahu 35 g/wadah), C (ampas tahu 40 g/wadah), D ampas tahu 45 g/wadah).  Hasil peneltian menunjukkan bahwa perlakuan D memberikan pengaruh terhadap pertambahan bobot cacing sutra dengan nilai rata-rata sebesar 48,76 gr, kemudia  diikuti dengan perlakuan C dengan nilai 41,96 gr, perlakuan B dengan nilai 39,5 gr, dan perlakuan A dengan nilai 32,25 gr. Penelitian ini menunjukkan bahwa pemberian fermentasi ampas tahu memberian pengaruh nyata (p<0,05) terhadap biomassa cacing sutra
PENGARUH PERBANDINGAN PEMBERIAN TEPUNG WORTEL (Daucus corata L) DAN LABU KUNING (Cucurbita moschata D) PADA PAKAN BUATAN TERHADAP PENINGKATAN KUALITAS WARNA IKAN KOI (Cyprinus carpio)
Authors: Julaini Nasri , Koniyo Yuniarti , Mulis Mulis
Published: February 2024

Penelitian ini bertujuan untuk mengetahui pengaruh perbandingan pemberian tepung wortel dan labu kuning pada pakan buatan terhadap peningkatan kualitas warna ikan koi. Metode yang digunakan adalah eksperimen dengan Rancangan Acak Lengkap (RAL) yang terdiri dari 4 perlakuan 3 kali ulangan. Perlakuan A =(100% Pelet), Perlakuan B =(85% pelet, 15% tepung wortel), Perlakuan C =(85% pelet, 15% tepung labu kuning), Perlakuan D =(70% pelet, 15% tepung wortel, 15% tepung labu kuning). Hasil penelitian menunjukan perlakuan D memberikan pengaruh terhadap peningkatan kecerahan warna ikan mas koi dengan nilai rata-rata sebesar 8.44, kemudian diikuti perlakuan B dengan nilai 7.69, perlakuan C dengan nilai 6.25, dan perlakuan A dengan nilai 5.14. Penelitian ini menunjukan bahwa penggunaan tepung wortel dan tepung labu kuning dalam pakan berpengaruh terhadap warna ikan mas koi.
A jégeső előrejelzés verifikációja
Authors: Baár Péter , Csirmaz Kálmán , Kelemen Tibor
Published: February 2024

Az Országos Meteorológiai Szolgálat 2018 óta végez jégeső előrejelzést a Nemzeti Agrárgazdasági Kamara részére. Az előrejelzés során kiadott riasztások verififikációjához megalkottunk egy úgynevezett radaros jeges feltételt, aminek segítségével a radarmérések alapján kellő tér- és időbeli pontossággal meg tudjuk határozni, hogy a konvektív cellák nagy valószínűséggel okoznak-e felszínt elérő jégesőt. Emellett az ECMWF modellből számolt konvektív paramétermezőket is vizsgáltuk, hogy megtudjuk, elkülöníthetők-e a felszínt elérő jégszemeket produkáló zivatarok kialakulásának körülményei a nem jeges zivatarokétól. Ez a tanulmány betekintést enged a fent említett radaros és modell alapú jegesség meghatározásának módszertanába, valamint bemutatja a verififikáció során felhasznált legfontosabb mutatókat és a 2023-as év eredményeit.
A Prototype of Monitoring and Early Warning System of Public Water Flow Interference based on Arduino, Firebase Realtime DB, and Android
Authors: Dharmaadi I Putu Arya , Arsa Dewa Made Sri , Sasmita Gusti Made Arya
Published: February 2024

The majority of the population uses clean water sourced from the PDAM (Indonesian Regional Water Supply Company) pipeline to meet their daily needs. However, clean water utilization is sometimes not smooth because the upstream's water supply is stalled or the PDAM pipeline disrupted. This disruption that often occurs slowly causes routine community activities, such as bathing or cooking, become stop because clean water is a basic need. Thus, a system is needed to provide early warning when the PDAM water supply starts to have problems so that the community can make initial anticipation. This study designed a prototype of an early warning system using an Arduino-based water flow sensor that records water flow discharge data on the PDAM pipeline and sent to the Firebase Realtime Database to be monitored in real-time through an Android application. The system testing is done by black-box testing, i.e. we check all functions of this system, mainly on sending a warning notification when the water flow debt is at a low rate. In the end, by using this system, the user can prepare themselves early, such as collecting residual water debit in the tub and save water when there is a disruption in PDAM water.
Students’ Perception for Online Lectures Quality in Universities in Yogyakarta
Authors: Wulandari Astri
Published: February 2024

The World of Education during the Covid-19 outbreak had to take a solution or problem solving by carrying out Teaching and Learning Activities online. Schools, campuses and even informal education facilities must go on online as a security solution while continuing to carry out learning activities in the midst of this epidemic. This study looks at the extent to which students’ assessments of the quality of online lectures in Yogyakarta. 100 students as respondents from 14 Universities in Yogyakarta participated in this survey. This study uses a quantitative method with reference to, quality assessment in the 2019 SPADA Learning Object Development Guide from the Directorate General of Learning and Students Affairs, Kemristekdikti, 2019. From the results of the study, it was found that the learning plan indicator had the highest average percentage of items is 35,5%, then the media and technology indicators have the highest percentage of items at 37,63% and the assessment and evaluation indicators have an average percentage of items is 45% which all the percentage indicators are on a pretty good rating scale. This shows that the student’s assessment of the quality of online lectures in Yogyakarta during the Covid-19 outbreak was quite goods in its implementation.
Application of theories on thinking to build the theory of mathematical thinking in teaching high school mathematics
Authors: Doc Nguyen Van , Giam Nguyen Minh , Nam Nguyen Thi Hoai , Giang Nguyen Thi Huong , Thanh Ngo Tu
Published: February 2024

The paper explores the development of a theory on mathematical thinking in the teaching of Mathematics at the high school level (HSL). The first part of the paper presents characteristics of thinking, including problem-solving, direct and indirect aspects, abstraction, generalization, and its close relationship with language. The process of thinking formation is described through various stages, where direct and indirect thinking holds a significant position. The following section classifies types of thinking such as logical thinking, imaginative thinking, and argumentative thinking. Additionally, it categorizes thinking into different levels of independence. Thinking is classified based on the object, the field of perception, and the thinking method. The crucial part of the paper focuses on mathematical thinking, describing it as a creative process applying mathematical methods, concepts, and procedures to solve problems. In conclusion, the paper constructs a theory of mathematical thinking in teaching Mathematics at HSL, aiming to develop and enhance mathematical capabilities in students by grasping fundamental knowledge and skills. It encourages core mathematical abilities such as thinking, modeling and problem-solving.
Safety of a historical Dam in Romania
Authors:   Technical Sciences Academy of Romania, STEMATIU DAN , ABDULAMIT ALTAN ,   Technical University of Civil Engineering, Bucharest, Romania
Published: February 2024

The safety of dams in Romania follows the current engineering trend and is governed by The Dam Safety Law, issued in 2001. A special concern refers to historical dams, where two cumulative contributing factors are endangering the safety - ageing and modifications in the catchment area that bring alterations in flood formation and flood characteristic values. To illustrate the specific problems, the paper presents a case hystory. The dam is one of the oldest storage reservoirs in Romania (Tăul Mare Dam), still operational, built prior to the 18th century in the Metaliferi Mountains in central Transylvania for the gold mines, where a relative minor incident has created a lot of concerns regarding the structure’s safety. Thorough investigations have revealed an intense degradation due to ageing and lack of proper maintenance. The proposed rehabilitation works consist in refurbishing the bottom outlet gallery and repairing and strengthening of the downstream face of the dam.
Active and passive safety systems of the automobile
Authors:   Transilvania University of Brasov, Department of Automotive and Transport Engineering,
29 Eroilor Blvd, 500036 Brasov, Romania, NEDELESCU CLAUDIU , CHIRU ANGHEL ,   Transilvania University of Brasov, Department of Automotive and Transport Engineering, 29 Eroilor Blvd, 500036 Brasov, Romania
Published: February 2024

This paper focuses on creating an overview of the current state of research (state of the art) on systems and equipment for active and passive safety of the vehicles. After classifying them, the limits are identified, as well as the technical solutions that are based on design technologies intended to increase the safety of vehicle occupants, pedestrians or other traffic participants in the event of an impact or in case of its prevention. Future approaches are presented at the end of the paper in terms of technical solutions of vehicles with Highly Automated Driving (HAD) technology, as well as how autonomous vehicles work.
Dependable Cyber-Physical Systems: concepts, challenges, and case studies
Authors:   Department of Automation, Faculty of Automation and Computer Science, Technical University of Cluj-Napoca, 400114, Romania, MICLEA LIVIU-CRISTIAN , CIOBOTARU ALEXANDRU ,   Department of Automation, Faculty of Automation and Computer Science, Technical University of Cluj-Napoca, 400114, Romania, MISAROS MARIUS ,   Department of Automation, Faculty of Automation and Computer Science, Technical University of Cluj-Napoca, 400114, Romania, CORCHES COSMINA ,   Department of Automation, Faculty of Automation and Computer Science, Technical University of Cluj-Napoca, 400114, Romania
Published: February 2024

As the integration of cyber and physical components becomes increasingly prevalent in modern systems, ensuring the dependability of Cyber-Physical Systems (CPS) has emerged as a critical research area. The present paper aims to present a comprehensive analysis of the recent advances in the field of dependable CPS. Firstly, we present an analysis on the evolution of the published papers in the past years and introduce the concepts of dependability and CPSs in the context of Industry 4.0. Secondly, some strategies and challenges that have been encountered in the recent literature for enhancing the dependability of CPS are also presented. Finally, two case studies that highlight the interdependencies between the concepts of dependability and CPS are reviewed. The first one presents the dependability of an object identification system that relies on radio frequency identifier, which can be used in medical services. The second case study shows various techniques for predicting the remaining useful life of a turbofan jet engine using Machine Learning and Deep Learning techniques.
Pathogenesis of an infected burn wound in rats
Authors:   Research and manufacturing company “Home оf Pharmacy”, Sultanova K.T. , Kryshen K.L. , Borovkova K.E. , Gushchin Ya.A. , Polyuga N.L.
Published: February 2024

Burns are a severe and widespread type of injury and are accompanied by local and systemic complications, leading to disability and death. Infection is a major complication of burn injury because thermal burns can cause disturbances of humoral and cellular immunity, and necrotized tissue ceases to perform its normal barrier function, which leads to the development of infection caused by environmental opportunistic microorganisms and commensals, which limits the ability of the skin to heal. In addition, the scab of a burn wound is a nutrient-rich environment that is easily colonized by microorganisms. Gram-positive bacteria are the first colonizers of the wound bed because they make up the microflora of the skin microbiome. Burn wounds are most commonly associated with Staphylococcus aureus, which is capable of producing virulence factors that slow wound healing. The frequency of thermal injuries and their subsequent infection necessitates the creation of new therapeutic agents as well as the development and adaptation of relevant model systems for preclinical studies. A sufficient number of in vivo models have been developed to study the pathogenesis of burn injuries, as well as to conduct specific studies as part of preclinical studies of potential therapeutic agents. Rats are an adaptable model for reproducing infected burn wounds and evaluating their course. The aim of the study was to evaluate the pathogenesis of infected burns, allowing further use of this model pathology in the study of a wide range of potential antiseptic and anti-burn agents. The study successfully generated a model of infected skin burn in Wistar rats. Creation of burn wounds was carried out by contact method, the inducing damage temperature was 100 °C, Staphylococcus aureus ATCC 25923 was used as an infectious agent. Evaluation of the dynamics of the course of an infected burn wound was carried out according to the results of planimetric, microbiological, cytological and histological studies. The developed model of an infected skin burn in rats is relevant to study the pharmacological activity of antiseptic agents and local anti-burn agents with an antimicrobial component of the mechanism of action.
Rabbits in preclinical research
Authors:   Research and manufacturing company “Home оf Pharmacy”, Makarova M.N. , Makarov V.G.
Published: February 2024

Rabbits are one of the most commonly used laboratory animal species in biomedical research. A large number of models of various human diseases have been developed on rabbits. Rabbits are widely used to assess the safety of substances and pharmaceuticals. The development of genetically modified rabbits has expanded their use for modeling various pathological conditions. Advantages of the rabbit include its relatively small size and relative ease of housing. Practically any experimental manipulations can be carried out on rabbits (any methods of administering the tested compounds are available, conducting various instrumental studies, multiple collection of blood samples, etc. is possible). In studies of reproductive toxicity, an important advantage of the rabbit relative to larger animals is a short gestation period, good reproductive ability. Rabbits are sensitive to human teratogens and are the preferred non-rodent species for embryofetal development studies. Rabbits are used in immunology for the production of diagnostic antibodies. An important point is that the scientific literature provides a sufficient amount of historical and reference materials on the anatomy, physiology, and pathophysiology of these animals. The disadvantages of rabbits include frequently developed disorders of the gastrointestinal tract. The functional activity of the rabbit’s digestive system is highly dependent on the diet. Changes in the diet should be done gradually. Rabbits need to be able to exercise daily. With the wrong manipulation technique, it is easy to cause injury to the rabbit. Since some diseases may spontaneously develop in laboratory rabbits, this may require either the use of therapy or the exclusion of the animal from the experiment. Therefore, in the case of planning long-term studies on rabbits, it is reasonable to include at least 8 males and 8 females in each group. If recovery groups are needed, the number of animals should be sufficient to evaluate possible long-term effects. When planning and conducting experiments, every effort should be made to implement the principles of 3Rs. Combination designs with pharmacological safety, immunotoxicity, reproductive toxicity, pharmacokinetics, and toxicokinetics studies as part of a toxicity study may help to reduce the number of rabbits in toxicological research. Studies should be designed taking into account the available scientific data on the test compound or on analogue compounds, on the basis of which scientific-based decision can be made to reduce the number of animals in the experiment without compromising the human safety.
The use of avian yolk antibodies in biomedical research
Authors:   Institute of Biochemistry — subdivision of FRC FTM, Kaplin V.S. ,   Institute of Medical Biotechnology FBSI SRC VB “Vector” of Rospotrebnadzor, Kaplina O.N.
Published: February 2024

Passive immunization, proposed by E. Behring, is still a sought-after treatment option using mammalian antibodies. This principle was developed by F. Klemperer in 1893, showing that antibodies that could inactivate the pathogen appeared in the egg yolks of chickens immunized with tetanus toxin. At this time, E. Behring, S. Kitasato, and other investigators studied the inactivating properties of mammalian sera, and an article by F. Klemperer on the transfer of active antibodies from chicken blood to egg yolk remained unattended. Only after the publication of the 3Rs principles by W.M.S. Russell and R.L. Burch in 1959, it was realized that the extraction of egg yolks from immunized birds was fully consistent with the principles of bioethics because the procedure was physiological and non-invasive. Researchers in many countries began to study the yolk immunoglobulins of birds of different species and use them in the diagnosis, therapy and prevention of human and animal diseases. The following species of birds are used for production of IgY-antibodies: chicken, quail, duck, goose, ostrich. Extraction of immunoglobulins from egg yolks of birds is not a difficult task. Many options for the isolation and purification of yolk immunoglobulins from different avian species have been described in the literature. IgY technology has attracted a lot of interest among researchers, especially in the last 10 years. In addition, advances in laboratory techniques and the application of other technologies in the field have resulted in IgY technology becoming more mature for industrial production of specific antibodies and commercialization of the process. Companies are emerging in many countries producing transovarian (yolk) antibodies against pathogens that cause dental caries, peptic ulcer, celiac disease and other diseases. IgY-technologies are a relatively new direction in immunology, based on the passive immunization technology of E. Behring, but it is not sufficiently appreciated in Russia. The replacement of mammalian IgG with avian transovarial IgY allows to develop commercially significant amounts of specific antibodies that do not cause side effects, expands the possibilities of passive immunization methods for the treatment of lesions caused by viruses, bacteria and toxins. This review describes the properties of IgY from different avian species and examples of their application in therapy and disease prevention.
Variability of blood biochemical parameters and establishment of reference intervals in preclinical studies. Part 10: mongolian gerbils
Authors:   Research and manufacturing company “Home оf Pharmacy”, Miroshnikov M.V. , Sultanova K.T. , Kovaleva M.A.
Published: February 2024

Gerbils as a type of laboratory animals are widely used as experimental models in a number of areas of biomedical research. This type of laboratory animals is relatively easy to maintain and handle. They are an alternative test system among rodents such as mice and rats. They are most often used in the study of cerebral ischemia or stroke, behavioral research, aging processes, the development of oncological diseases, as well as the study of para­sitic, viral and bacterial infections, studies of the mechanisms and therapy of epileptic seizures and metabolic disorders such as obesity and diabetes mellitus. The aim of this work was to create a database of reference intervals of biochemical parameters of normal healthy mature Mongolian gerbils with further use in daily routine laboratory practice in preclinical centers. The data that were used to form the reference intervals were obtained from intact animals in “Home оf Pharmacy”. All manipulations and experiments were approved by the bioethical commission. The study involved 20 males and 20 females (non-pregnant excluding the estrous cycle phase) of Mongolian gerbils. The age of the animals corresponded to the range of 6–8 weeks, the body weight of males and females was within 60 g. The levels of the following parameters were determined in the blood serum of animals: creatinine, urea, alanine aminotransferase, aspartateaminotransferase, alkaline phosphatase, cholesterol, triglycerides, total protein, albumin, glucose, total bilirubin, the number of globulins was calculated, as well as the ratio of albumin/globulins. The obtained ranges of males and females had no statistical difference between them. These intervals were analyzed for comparison with other reference intervals of gerbils found in the scientific literature, as well as with ranges of similar indicators characteristic of humans. Norms of biochemical parameters of blood serum of gerbils are an important tool necessary for monitoring animal health during biomedical research, monitoring the dynamics of modeling pathological conditions in animals and studying the safety of new pharmacological agents. An important aspect in preclinical research is the creation of any reference intervals of laboratory animals in each scientific center separately. This is due to a large number of pre-analytical, analytical and post-­analytical features, as well as minimizing the risk of misinterpretation of the data obtained during biomedical research.
Muc 2-deficient mice as a model of chronic inflammation
Authors:   Faculty of Medicine of M.V. Lomonosov MSU, Milutinovich K.S. , Popov V.S.
Published: February 2024

The article provides an overview of the most significant works of domestic and foreign authors devoted to the Ehrlich ascites carcinoma biological model. The analysis of the available literary sources showed that despite the long history of the existence of this model and its application in biomedical research, it has not yet become widespread in veterinary medicine. It should be noted that the Ehrlich ascites carcinoma model has a number of peculiarities that allow it to be used for the needs of veterinary medicine, in particular, experimental pharmacology at the stage of drug design and its preclinical testing. The high resistance of malignant cells and tumor survival in experimental animals, as well as the ease of its cultivation and relatively rapid tumor growth, make this model a convenient biological object for research. The effect of tumor cells on the body of the animal with a tumor leads to a change in a number of biochemical indicators of various tissues and organs, and a general toxic effect. In this case, an imbalance of the free-radical and antioxidant systems is observed, the body is exposed to oxidative stress. The immune system under the effect of Ehrlich ascites carcinoma also undergoes a number of changes. Thus, in response to the development of tumor-induced pathological processes, recruitment of immunocompetent cells and an antitumor immune response are observed, which at the same time is suppressed as carcinoma cells grow under the action of immunosuppressive physiologically active compounds produced by the tumor, escape of tumor cells from immunological surveillance and remodelling of immune cells in the tumor microenvironment. These processes lead to suppression of the immune system and as a result to the death of animals. These peculiarities make it possible to use the Ehrlich transplantable ascites carcinoma model for testing new veterinary drugs with potential antiblastoma, immunomodulatory, antitoxic properties, as well as medicinal formulations for restoring biochemical indicators and redox homeostasis under conditions of tumor-induced immunosuppression and chronic inflammatory process, and also to study the mechanisms of cell adaptation, including the immune system, under the action of carcinogenesis factors.
Data Analysis of Biomechanical Dynamic Modeling of a Prosthetic Running Blade
Authors: Siddiqui Md Irfanul Haque , Alamro Nawaf , Alluhydan Khalid
Published: February 2024

This study presents a comprehensive data analysis of the biomechanical performance of prosthetic running blades, utilizing vast data obtained from finite element simulations to elucidate the dynamics of force and energy under operational conditions. The primary focus is on understanding the behavior of these prosthetics at a speed of ‘1
m/s’ and exploring the stability and fluctuations of various force and energy components. Key findings reveal that the kinetic energy of the blade and the total system energy exhibit minimal fluctuations, indicating a stable system behavior under the tested conditions. The normal contact force
F
c
shows a significant dynamic response, while the normal velocity
V
y
maintains a consistent downward trajectory, and the tangential force
F
x
remains essentially constant. Notably, a strong positive correlation between the force components
F
c
and
F
x
is observed, suggesting a synchronous relationship in their magnitudes. Additionally, a moderate negative correlation between the normal velocity
V
y
and the kinetic energies of the blade and system is identified, highlighting intricate interdependencies. This research contributes significantly to the understanding of prosthetic running blades, offering insights crucial for their design and optimization. The correlations and patterns identified underscore the need for further investigation into the causal relationships and practical implications of these dynamics in prosthetic technology.
CNS Fungal Infections in Liver Transplantation
Authors: Khodashahi Rozita , Akhavan Rezayat Kambiz , Abdollahzade Aref , Arjmand Mohammad-Hassan , Bidi Ebrahim , Rahimi Hoda , Aliakbarian Mohsen
Published: February 2024

Context: Liver transplant recipients are highly susceptible to infections, including those affecting the central nervous system (CNS), due to their compromised immune systems and underlying chronic comorbidities. Results: Despite recent advancements in diagnostic and treatment modalities, post-transplant fungal infections continue to affect these patients. CNS fungal infections following liver transplantation pose a significant challenge in the diagnostic and therapeutic management of transplant recipients. Timely diagnosis and treatment are crucial because these infections are often identified late, leading to substantial morbidity and mortality in this patient population. Conclusions: This mini-review aims to explore the incidence of CNS fungal infections in liver transplant recipients, the key opportunistic pathogens involved, the associated risk factors, various clinical presentations, and the importance of preventive measures.
Jana Šrámková (nejen) pro děti
Authors: Nováková Luisa
Published: February 2024

The study reflects on the work of contemporary Czech children's literature writer, belonging to the younger middle generation, Jana Šrámková. It focuses especially on her latest prose Fánek hvězdoplavec. The study tries to identify characteristic features of the author's poetics, the key motifs of her works and the relationship to the child reader. All this is situated within the context of author's work for adults.
Planificación urbana y conjuntos habitacionales en el Norte Grande de Chile: el caso de Iquique: 1936-1976
Authors: Valenzuela-Grollmus Victor
Published: February 2024

En el norte de Chile, se ubican cuatro ciudades-puerto; Arica, Iquique, Tocopilla y Antofagasta. Ciudades que tienen en común, características geográficas que moldearon y confinaron su emplazamiento, lo que junto a las condiciones sociales y urbanas, configuraron una forma de habitar un paisaje extremo. Entre 1936 y 1976, los conjuntos habitacionales construidos por instituciones públicas , privadas y mixtas, no solo aportaron en la consolidación y crecimiento de estas ciudades, si no que también, se transformaron en referentes y casos distintivos en la producción de arquitectura moderna, instalando una modernidad arquitectónica en un paisaje extremo. Seleccionando como caso de estudio la ciudad de Iquique, la presente investigación busca profundizar la dialéctica entre el instrumento de planificación urbana y los conjuntos habitacionales, con la finalidad de determinar su rol en la configuración de la ciudad y como piezas urbanas fundamentales para su desarrollo.

In the north of Chile, there are four port-cities; Arica, Iquique, Tocopilla and Antofagasta. Cities that have in common, geographical characteristics that shaped and confined their location, which together with the social and urban conditions, configured a way of inhabiting an extreme landscape. Between 1936 and 1976, the housing complexes built by public, private and mixed institutions not only contributed to the consolidation and growth of these cities, but also became benchmarks and distinctive cases in the production of modern architecture, installing a architectural modernity in an extreme landscape. Selecting the city of Iquique as a case study, this research seeks to deepen the dialectic between the urban planning instrument and the housing complexes, in order to determine their role in the configuration of the city and as fundamental urban pieces for its development.
El paisaje habitacional moderno y el valor de su vegetación continua
Authors: Gertosio Swanston Rodrigo
Published: February 2024

Las amplias áreas verdes son parte del patrimonio de diversos conjuntos habitacionales del Movimiento Moderno. Pero más allá de su belleza escénica, la estructura en que los espacios verdes se distribuyen de forma continua y en distintas escalas en el espacio abierto, advierten la presencia de importantes servicios ecosistémicos que es preciso identificar y analizar especialmente en contexto de cambio climático, y con ello, generar nuevas capas de conocimiento que busquen asegurar su preservación. Mediante el cruce de planos nolli, imágenes satelitales y el índice NDVI, la presente investigación busca demostrar cómo la morfología urbana de estos conjuntos promueve espacios verdes continuos, y en distintas escalas. Lo anterior responde a dos factores entrecruzados: una baja proporción de ocupación de suelo por bloques permite amplias superficies de suelo permeable, en grandes manzanas escasamente interrumpidas por franjas de suelo sellado. Ambas características están presentes tanto en los casos patrimoniales, como en incontables otros conjuntos de Chile y el mundo construidos a mediados del siglo XX.

Extensive green areas are part of the heritage of several modern housing estates. They represent a landscape loaded with cultural values and multiple environmental benefits, thanks to the concentration and continuity of its vegetation. However, drought and the constant rise in temperatures constitute a chain threat that challenges their heritage and environmental conservation. By cross-referencing nolli maps, satellite images, and the NDVI index, this research seeks to demonstrate how the urban morphology of these complexes promotes continuous green spaces at different scales. This is due to two intertwined factors: the low land use ratio of the blocks allows for large areas of open soil in large blocks that are barely interrupted by strips of sealed soil. Both characteristics are present in the heritage cases and countless other complexes in Chile and the world built in the mid-twentieth century.
Índice QRU14
Authors: Peremiquel Lluch Francisco , Vilches Valenzuela Francisca Isabel
Published: February 2024

Quaderns de Recerca en Urbanisme (QRU) en su número 14 recoge trabajos de investigación que abordan el desafío de las periferias urbanas. Desde una visión global, las contribuciones a este número suponen la interpretación de una realidad compleja y diversa, que responde a la representación de ámbitos tan generalizables como específicos. La intención de organizar los trabajos aquí presentados no solo era la de reflexionar sobre periferias concretas, sino que también, sobre formas de aproximación en diferentes ámbitos y escalas, prototípicos y generalizables. Periferias que proliferan por el mundo y de las cuales aún hoy, se desconoce mucho de sus haberes y saberes.
Pengembangan Media Pembelajaran Berbasis Augmented Reality (AR) pada Mata Pelajaran IPAS Kelas VIII SMP
Authors: Salmanura Fadhila , Hendri Nofri
Published: February 2024

Augmented Reality (AR) learning media is a new learning innovation that displays interesting 3D animation visuals and makes complex and abstract concepts more real so that it triggers students' interest and curiosity in learning, so it can be used as an alternative in learning problems. This study aims to develop learning media for IPAS Class VIII Junior High School in order to produce valid media that is practical and effective for use by teachers and students This type of research is a development research (Reseacrh an Development) with the 4D (Four-D) development model. The average score for media validity assessment using Likert scale percentage presentation with media assessment by validator I is 4.93 and the percentage of 98% is categorized as "very valid", validator II is 4.73 with a percentage of 94% categorized as "very valid". And the average score of the material validator is 4.79 with a percentage of 95% categorized as "very valid". The research was conducted in 4 stages, the first stage by conducting curriculum analysis, learner analysis, and concept analysis. Then the initial product development was carried out by making flowcharts and storyboards and then making learning media with the Aseemblr edu application. Furthermore, the validity test stage is carried out by media and material validators, the last one is conducting a practicality trial and effectiveness trial for VIII grade junior high school students.
Upaya Untuk Meningkatkan Berat Badan Tubuh Pada Bayi Dengan Metode Pijat Di Mojogedang, Karanganyar
Authors: Retnowati Diah Dewi , Ristiana Dina , Utami Dyah Fitri Esti , Rahmadani Egi , Dani Elsa Rahma
Published: February 2024

Tujuan tumbuh kembang adalah untuk mengetahui pertumbuhan dan perkembangan anak serta untuk menemukan gangguan tumbuh secara dini sehingga dapat ditindaklanjuti untuk memperbaiki hasil. Ibu dan bayi dapat berkomunikasi dengan nyaman dengan pijat bayi, juga disebut stimulus sentuhan. Orang tua jarang menggunakan pijat bayi, terapi sentuhan yang sudah lama dikenal. Pemijatan bayi akan membuat mereka lapar, membuat mereka lebih sering menyusu. Dengan kekuatan otot saraf vagus, cabang saraf vagus dapat mengeluarkan hormon penyerapan makanan dan meningkatkan kadar enzim penyerapan gastrin dan insulin. Oleh karena itu, bayi yang dipijat akan lebih cepat tumbuh karena penyerapan sari makanan yang lebih baik.
Pendampingan Strategi Content marketing Produk Pemanfaatan limbah Ternak Pada Peternak Sapi di Desa Pare Kabupaten Wonogiri
Authors: Fatonah Siti , Panglipurningrum Yofhi , Khristiana Yenni
Published: February 2024

Tujuan dari Pengabdian Kepada Masyarakat ini adalah untuk memberikan peternak sapi informasi dan keterampilan pagi untuk mengembangkan marketing teknologi untuk memasarkan produk pemanfaatan limbah sapi di Desa Pare, Kecamatan Selogiri, Kabupaten Wonogiri. Strategi sangat penting dalam bisnis untuk menarik pelanggan untuk membeli dan menggunakan barang yang dijual. Di tahap ini, Anda dapat membeli barang yang memenuhi kebutuhan dan keinginan Anda. Dari Pendampingan pengelolaan konten Marketing melalui Video yang diupload di media sosial dan marketplace dapat memberikan manfaat tambahan ilmu dan pengalaman serta memberi motivasi kepada petani Ternak sapi dalam memasarkan produknya.
Pelatihan Manajemen Ritel Bagi UMKM Toko Kelontong sebagai Bentuk Kerjasama Perguruan Tinggi dan Mitra Industri
Authors: Agustina Tri Siwi
Published: February 2024

The presence of minimarkets that are getting closer to residents in housing and the presence of technology has changed the behavior of retail store consumers from shopping at grocery stores that tend to be managed conventionally to modern stores. Based on this phenomenon, this collaboration activity between FEB UNAIR and BULOG for East Java Region was carried out. The Retail Management Training was held in November with a target audience of 35 grocery store owners in Tegalsari District. The training was carried out by lecture method, and question and answer. The positive response from participants is good news for the implementation of SUIC and is expected to be sustainable. It is realized that this activity is still far from perfect in equipping grocery store’s owners, therefore, in order to be sustainable, it is hoped that there will be further activities so that grocery stores in Tegalsari District can attract buyers and be competitive.
Determinants Of Investment Portfolio Performance: A Systematics Literature Review
Authors: Yuliana Rena , Siwiyanti Leonita , Purnomo Budi Supriatono , Purnamasari Imas
Published: February 2024

A thorough grasp of the variables influencing portfolio performance is necessary given the significance of investment portfolio management in the face of shifting financial market dynamics. This study uses a method called the Systematic Literature Review (SLR) approach with an emphasis on Prefered Reporting Item for Systematic Review and Meta-Analysis (PRISMA) 2020, which has not been discovered in prior research on the same issue. The study highlights the importance of ratios like Sharpe, Treynor, Jensen, and Sortino in assessing investment portfolio success. It also highlights the impact of non-financial variables like household preferences on performance. Return is crucial, and diversification can lower risk and boost returns. The study emphasizes the use of Value-at-Risk (VaR) for dynamic risk evaluation.
The Influence of Education and Participation in Decision Making on Women's Empowerment
Authors: Yahya Siskawaty , Darman Darman , Hadjatu Sri
Published: February 2024

This research tries to explain the influence of education and partici-pation in decision-making on women's empowerment, by observing a sample of 53 women in the village. The data were analyzed using Partial Least Squares Structural Equation Modelling (PLS-SEM) methods using the SMARTPLS version 3 software. The samples were chosen and gathered via purposive sampling and disseminated us-ing an online questionnaire using Google form. The results show that education has an insignificant effect, with a Tstatistics value of 5.600 and P values of 0.000, while participation in decision-making has a significant effect, with a Tstatistics value of 2.295 and P value of 0.022 on women's empowerment.