bluuebunny/crossref_metadata_2025 huggingface dataset:
Evolutionary Game Analysis of the Effects of Problem Size and the Problem Proposing Mechanism on the Problem Processing Mechanism in a New Main Manufacturer–Supplier Collaborative System
Authors: Zhang Ming , Zhu Jianjun , Kumaraswamy Ponnambalam , Wang Hehua
Published: July 2019

This paper analyzed the effects of the problem size and the problem proposing mechanism on the decision-making processes, for the manufacturer and the supplier, regarding processing a problem in a new main manufacturer–supplier collaborative system using evolutionary game theory. Unpredicted problems may arise in the process of collaborative research and development (R&D) of complex products, like big passenger aircrafts, without any relative advanced contract, and either player will take risks to announce it. In addition to the factors of traditional cost and income, we take another two factors (i.e., the problem size and the problem proposing mechanism) into account in the examination of the problem processing mechanism. With evolutionary game theory applied, we can obtain the stable decision-making states of both players and how these two factors affect the problem processing mechanism. From the result, we find that the problem size has little effect on the two players’ decisions, while the problem processing mechanism has an impact when the experiences or the capacities of the manufacturer and the supplier are unbalanced. This paper contributes to manufacturer and supplier in a newly-established collaborative system to consider how to behave when unpredicted problems come.
Asymmetric Orlicz Radial Bodies
Authors: Li Hai , Wang Weidong , Ma Tongyi
Published: July 2019

Based on the L p -harmonic radial combination, Li and Wang researched the asymmetric L p -harmonic radial bodies, which belong to the asymmetric L p -Brunn-Minkowski theory initiated by Ludwig, Haberl and Schuster. In this paper, combined with Orlicz radial combination, we introduce the asymmetric Orlicz radial bodies and research their properties. Further, we also establish some inequalities for this concept.
Satisfying Bank Capital Requirements: A Robustness Approach in a Modified Roy Safety-First Framework
Authors: Atta Mills Ebenezer Fiifi Emire , Yu Bo , Zeng Kailin
Published: July 2019

This study considers an asset-liability optimization model based on constraint robustness with the chance constraint of capital to risk assets ratio in a safety-first framework under the condition that only moment information is known. This paper aims to extend the proposed single-objective capital to risk assets ratio chance constrained optimization model in the literature by considering the multi-objective constraint robustness approach in a modified safety-first framework. To solve the optimization model, we develop a deterministic convex counterpart of the capital to risk assets ratio robust probability constraint. In a consolidated risk measure of variance and safety-first framework, the proposed distributionally-robust capital to risk asset ratio chance-constrained optimization model guarantees banks will meet the capital requirements of Basel III with a likelihood of 95% irrespective of changes in the future market value of assets. Even under the worst-case scenario, i.e., when loans default, our proposed capital to risk asset ratio chance-constrained optimization model meets the minimum total requirements of Basel III. The practical implications of the findings of this study are that the model, when applied, will provide safety against extreme losses while maximizing returns and minimizing risk, which is prudent in this post-financial crisis regime.
Antagonism of Quorum Sensing Phenotypes by Analogs of the Marine Bacterial Secondary Metabolite 3-Methyl-N-(2′-Phenylethyl)-Butyramide
Authors: Meschwitz Susan M. , Teasdale Margaret E. , Mozzer Ann , Martin Nicole , Liu Jiayuan , Forschner-Dancause Stephanie , Rowley David C.
Published: July 2019

Quorum sensing (QS) antagonists have been proposed as novel therapeutic agents to combat bacterial infections. We previously reported that the secondary metabolite 3-methyl-N-(2′-phenylethyl)-butyramide, produced by a marine bacterium identified as Halobacillus salinus, inhibits QS controlled phenotypes in multiple Gram-negative reporter strains. Here we report that N-phenethyl hexanamide, a structurally-related compound produced by the marine bacterium Vibrio neptunius, similarly demonstrates QS inhibitory properties. To more fully explore structure–activity relationships within this new class of QS inhibitors, a panel of twenty analogs was synthesized and biologically evaluated. Several compounds were identified with increased attenuation of QS-regulated phenotypes, most notably N-(4-fluorophenyl)-3-phenylpropanamide against the marine pathogen Vibrio harveyi (IC50 = 1.1 µM). These findings support the opportunity to further develop substituted phenethylamides as QS inhibitors.
Prevention of Food Allergy: The Significance of Early Introduction
Authors: Comberiati Pasquale , Costagliola Giorgio , D’Elios Sofia , Peroni Diego
Published: July 2019

Over the last two decades, the prevalence of food allergies has registered a significant increase in Westernized societies, potentially due to changes in environmental exposure and lifestyle. The pathogenesis of food allergies is complex and includes genetic, epigenetic and environmental factors. New evidence has highlighted the role of the intestinal microbiome in the maintenance of the immune tolerance to foods and the potential pathogenic role of early percutaneous exposure to allergens. The recent increase in food allergy rates has led to a reconsideration of prevention strategies for atopic diseases, mainly targeting the timing of the introduction of solid foods into infants’ diet. Early recommendation for high atopy risk infants to delay the introduction of potential food allergens, such as cow’s milk, egg, and peanut, until after the first year of life, has been rescinded, as emerging evidence has shown that these approaches are not effective in preventing food allergies. More recently, high-quality clinical trials have suggested an opposite approach, which promotes early introduction of potential food allergens into infants’ diet as a means to prevent food allergies. This evidence has led to the production of new guidelines recommending early introduction of peanut as a preventive strategy for peanut allergy. However, clinical trials investigating whether this preventive dietary approach could also apply to other types of food allergens have reported ambiguous results. This review focuses on the latest high-quality evidence from randomized controlled clinical trials examining the timing of solid food introduction as a strategy to prevent food allergies and also discusses the possible implications of early complementary feeding on both the benefits and the total duration of breastfeeding.
Interventions Based on Mind–Body Therapies for the Improvement of Attention-Deficit/Hyperactivity Disorder Symptoms in Youth: A Systematic Review
Authors: Barranco-Ruiz Yaira , Esturo Etxabe Bingen , Ramírez-Vélez Robinson , Villa-González Emilio
Published: July 2019

Background and objectives: Attention-deficit/hyperactivity disorder (ADHD) is one of the most common psychiatric disorders in children and adolescents. Mind–body therapies (MBTs) seem to be effective for improving health in different populations; however, whether a positive effect occurs in children and adolescents with ADHD is still controversial. The main aim of this systematic review was to analyse the interventions based on MBT aimed to improve the main ADHD symptoms in children and adolescents. Materials and Methods: A systematic review was conducted following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines to identify MBT studies on children and adolescents (4–18 years) with a clinical diagnosis of ADHD. Study quality was evaluated by the NIH quality tool (U.S. National Institute of Health). Results: There were positive results in eleven out of twelve included studies regarding the effect of the MBT interventions on ADHD symptoms. With respect to ADHD symptoms, we observed differences across studies. In relation to the studies’ quality, eleven studies were rated “poor” and one was rated as “fair”. Conclusions: MBTs, such as yoga or mindfulness, could be positive strategies to mitigate ADHD symptoms in children and adolescents. However, further research with high-quality designs, with randomization, greater sample sizes, and more intensive supervised practice programs are needed.
5th UK–China Steel Research Forum
Authors: Dong Hanshan , Dong Hongbiao , Li Zushu
Published: July 2019

Following the past successful four events in Leicester (2010), Wuhan (2012), Oxford (2014) and Chongqing (2016), the 5th UK–China Steel Research Forum, in conjunction with the 16th Conference of Chinese Materials Association in the UK on Materials Science and Engineering, was held at the University of Birmingham, UK on 4–7 July 2018 [...]
Assembly of Microparticles to Patterned Trenches Using the Depletion Volume Effect
Authors: Mori Yaoki , Kawai Ryota , Suzuki Hiroaki
Published: June 2019

In this paper, we demonstrate that 20 μm microbeads can be preferentially assembled into substrate trenches of similar width by employing a polymer (depletant) that induces the depletion volume effect (depletion attraction). In previous works, we proved that this strategy is useful to assemble mesoscale parts in a site-specific manner. Here, we show that it is also applicable to assemble functional parts, such as fluorescent particles, into trenches engraved on the surface of two- and three-dimensional template components. A convenient advantage of this strategy is that it is independent of material properties for assembling mesoscale functional components into desired patterns.
4D Printing of Multi-Hydrogels Using Direct Ink Writing in a Supporting Viscous Liquid
Authors: Uchida Takuya , Onoe Hiroaki
Published: July 2019

We propose a method to print four-dimensional (4D) stimuli-responsive hydrogel structures with internal gaps. Our 4D structures are fabricated by printing an N-isopropylacrylamide-based stimuli-responsive pre-gel solution (NIPAM-based ink) and an acrylamide-based non-responsive pre-gel solution (AAM-based ink) in a supporting viscous liquid (carboxymethyl cellulose solution) and by polymerizing the printed structures using ultraviolet (UV) light irradiation. First, the printed ink position and width were investigated by varying various parameters. The position of the printed ink changed according to physical characteristics of the ink and supporting liquid and printing conditions including the flow rates of the ink and the nozzle diameter, position, and speed. The width of the printed ink was mainly influenced by the ink flow rate and the nozzle speed. Next, we confirmed the polymerization of the printed ink in the supporting viscous liquid, as well as its responsivity to thermal stimulation. The degree of polymerization became smaller, as the interval time was longer after printing. The polymerized ink shrunk or swelled repeatedly according to thermal stimulation. In addition, printing multi-hydrogels was demonstrated by using a nozzle attached to a Y shape connector, and the responsivity of the multi-hydrogels to thermal-stimulation was investigated. The pattern of the multi-hydrogels structure and its responsivity to thermal-stimulation were controlled by the flow ratio of the inks. Finally, various 4D structures including a rounded pattern, a spiral shape pattern, a cross point, and a multi-hydrogel pattern were fabricated, and their deformations in response to the stimuli were demonstrated.
Translational MEMS Platform for Planar Optical Switching Fabrics
Authors: Sharma Suraj , Kohli Niharika , Brière Jonathan , Ménard Michaël , Nabki Frederic
Published: July 2019

While 3-D microelectromechanical systems (MEMS) allow switching between a large number of ports in optical telecommunication networks, the development of such systems often suffers from design, fabrication and packaging constraints due to the complex structures, the wafer bonding processes involved, and the tight alignment tolerances between different components. In this work, we present a 2-D translational MEMS platform capable of highly efficient planar optical switching through integration with silicon nitride (SiN) based optical waveguides. The discrete lateral displacement provided by simple parallel plate actuators on opposite sides of the central platform enables switching between different input and output waveguides. The proposed structure can displace the central platform by 3.37 µm in two directions at an actuation voltage of 65 V. Additionally, the parallel plate actuator designed for closing completely the 4.26 µm air gap between the fixed and moving waveguides operates at just 50 V. Eigenmode expansion analysis shows over 99% butt-coupling efficiency the between the SiN waveguides when the gap is closed. Also, 2.5 finite-difference time-domain analysis demonstrates zero cross talk between two parallel SiN waveguides across the length of the platform for a 3.5 µm separation between adjacent waveguides enabling multiple waveguide configuration onto the platform. Different MEMS designs were simulated using static structural analysis in ANSYS. These designs were fabricated with a custom process by AEPONYX Inc. (Montreal, QC, Canada) and through the PiezoMUMPs process of MEMSCAP (Durham, NC, USA).
Development of a Surface Plasmon Resonance and Fluorescence Imaging System for Biochemical Sensing
Authors: Zhang Lulu , Miao Guijun , Zhang Jing , Liu Luyao , Gong Shisong , Li Yichen , Cui Dafu , Wei Yuanchen , Yu Duli , Qiu Xianbo , Chen Xing
Published: July 2019

Surface plasmon resonance (SPR) biosensors are an extremely sensitive optical technique used to detect the changes in refractive index occurring at the sensor interface. Fluorescence involves the emission of light by a substance that has absorbed light or other electromagnetic radiation, and the parameters of the absorbed and emitted radiation are used to identify the presence and the amount of specific molecules in a specimen. SPR biosensors and fluorescence analysis are both effective methods for real-time detection. The combination of these technologies would improve the quantitative detection sensitivity of fluorescence analysis and the specificity of SPR detection. We designed and developed an SPR and fluorescence synchronous detection system. The SPR module was based on two kinds of modulation methods, and the fluorescence module was capable of switching between four wavelengths. The fluorescence microspheres and A549 cells of different concentration were both detected by the SPR and fluorescence method synchronously in real time. The fluorescent signal and the optical signal of the SPR were shown to correlate. The correlation coefficient for fluorescent microspheres detection reached up to 0.9866. The system could be used in cell analysis and molecule diagnosis in the future.
Mineralogy and Pretreatment of a Refractory Gold Deposit in Zambia
Authors: Wang Xu , Qin Wenqing , Jiao Fen , Yang Congren , Cui Yanfang , Li Wei , Zhang Zhengquan , Song Hao
Published: July 2019

The technological mineralogy of a gold deposit located in North-Western province of Zambia was carried out by using X-ray fluorescence spectroscopy (XRF), X-ray diffraction spectroscopy (XRD), and scanning electron microscope (SEM). The results showed that gold was highly dispersed in gold-bearing minerals such as pyrite, arsenopyrite, and some gangues in the form of natural gold and electrum. The gold grade in the mineral was 15.96 g/t and the particle size distribution of gold was extremely uneven. Most of the gold particles were less than 10 μm and wrapped with gold-bearing minerals, making it difficult to achieve liberation during grinding. According to the characteristics of the refractory gold deposit, the gravity–flotation combined beneficiation process was used to recover the liberated coarse gold and the fine gold in the sulphides. The closed-circuit experiments obtained excellent indicators. The grade and recovery of gold in the gravity separation concentrates reached 91.24 g/t and 57.58%, respectively. The grade and recovery of gold in the flotation concentrates were 49.44 g/t and 33.36%, respectively. The total recovery of gold was 90.94%. The gravity–flotation combined beneficiation pretreatment process provided a feasible method for the refractory gold ore and ensured the effective recovery of gold.
A Facile Method to Synthesize CdSe-Reduced Graphene Oxide Composite with Good Dispersion and High Nonlinear Optical Properties
Authors: Li Pengchao , Zhu Baohua , Li Peng , Zhang Zhihao , Li Luyao , Gu Yuzong
Published: July 2019

CdSe-reduced graphene oxide (CdSe/RGO) composites were synthesized by a hydrothermal method. CdSe/RGO composites with different mass ratios were prepared. The structure and morphology of CdSe/RGO composites were analyzed by X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The synthesis of CdSe/RGO complexes was successfully demonstrated by Fourier infrared (FT-IR) and Raman spectra. CdSe nanoparticles in the CdSe/RGO composite were uniformly dispersed on the graphene surface. The study found that oxygen-containing functional groups such as hydroxyl (-OH) and carboxyl (-COOH) groups in graphene played a decisive role in the dispersion of CdSe. The third-order nonlinear optical properties of CdSe/RGO composites were measured by a single beam Z-scan technique. The experimental results showed that composites exhibited two-photon absorption and self-focusing nonlinear refraction properties. Additionally, the third-order nonlinear susceptibility of the composite material was obviously enhanced, which was mainly due to the good dispersion of CdSe nanoparticles on graphene.
Fabrication of Novel Printable Electrically Conductive Adhesives (ECAs) with Excellent Conductivity and Stability Enhanced by the Addition of Polyaniline Nanoparticles
Authors: Wen Jiayue , Tian Yanhong , Hang Chunjin , Zheng Zhen , Zhang He , Mei Zhipeng , Hu Xuanyi , Tian Yanqing
Published: July 2019

Electrically conductive adhesives (ECAs) are one of the low temperature bonding materials. It can be used to replace toxic Sn-Pb solder. The key issue for the application of ECAs is how to improve their electrical properties. In the present study, we develop an effective method to promote the electrical properties of ECAs by addition of polyaniline (PANI) nanoparticles. PANIs were synthesized via a facile one-step chemical oxidative polymerization method. After adding 0.5 wt% PANI nanoparticles, the conductivity of ECAs increased dramatically by an order of magnitude. The bulk resistivity of 8.8 × 10−5 Ω·cm is achieved for 65 wt% silver fillers with 0.5 wt% PANIs loaded ECAs. Besides, this improvement has no negative effect on the shear strength and the aging life of ECAs. Moreover, the use of PANIs not only lowers the percolation threshold of ECAs, but also reduces the cost and improves the bonding reliability. Finally, PANIs enhanced ECAs patterns were successfully printed by a stencil printing method, which proved their potential applications in replacing conventional solder pastes and printing functional circuits.
Comparison of the Clinical Implications among Five Different Nutritional Indices in Patients with Lupus Nephritis
Authors: Ahn Sung Soo , Yoo Juyoung , Jung Seung Min , Song Jason Jungsik , Park Yong-Beom , Lee Sang-Won
Published: July 2019

Systemic lupus erythematosus (SLE) is characterized with aberrant responses in the immune systems and lupus nephritis (LN) is one of the most serious complications of SLE. This study evaluated the clinical significance of different nutritional indices in 207 renal biopsy-proven LN patients. The clinical and laboratory data were reviewed, and five different nutritional indices were calculated: (i) Controlling nutritional status (CONUT) score; (ii) prognostic nutritional index (PNI); (iii) nutritional risk index; (iv) neutrophil-to-lymphocyte ratio; and (v) body mass index. The factors associated with end-stage renal failure (ESRF) were assessed using a Cox-proportional hazard analysis. The patients with ESRF had significantly lower median PNI (31.1 vs. 34.7, p = 0.012) than those without ESRF at baseline. The CONUT score and PNI had the highest correlation between the SLE disease activity index-2000 (r = 0.467 and p = −0.356, all p < 0.001) and was significantly associated with SLE activity-related measures. In the Cox-proportional hazard analysis, PNI (odds ratio 0.925, 95% confidence interval 0.865–0.989, p = 0.022) was independently associated with ESRF along with creatinine and chronicity index, and the renal survival rate was significantly lower in patients with PNI ≤35.41 than in those with PNI >35.41 (p = 0.003). Among nutritional indices, the CONUT score and PNI better correlated with disease activity and PNI was associated with ESRF.
Carbohydrates in Human Milk and Body Composition of Term Infants during the First 12 Months of Lactation
Authors: Gridneva Zoya , Rea Alethea , Tie Wan Jun , Lai Ching Tat , Kugananthan Sambavi , Ward Leigh C. , Murray Kevin , Hartmann Peter E. , Geddes Donna T.
Published: June 2019

Human milk (HM) carbohydrates may affect infant appetite regulation, breastfeeding patterns, and body composition (BC). We investigated relationships between concentrations/calculated daily intakes (CDI) of HM carbohydrates in first year postpartum and maternal/term infant BC, as well as breastfeeding parameters. BC of dyads (n = 20) was determined at 2, 5, 9, and/or 12 months postpartum using ultrasound skinfolds (infants) and bioelectrical impedance spectroscopy (infants/mothers). Breastfeeding frequency, 24-h milk intake and total carbohydrates (TCH) and lactose were measured to calculate HM oligosaccharides (HMO) concentration and CDI of carbohydrates. Statistical analysis used linear regression/mixed effects models; results were adjusted for multiple comparisons. Higher TCH concentrations were associated with greater infant length, weight, fat-free mass (FFM), and FFM index (FFMI), and decreased fat mass (FM), FM index (FMI), %FM and FM/FFM ratio. Higher HMO concentrations were associated with greater infant FFM and FFMI, and decreased FMI, %FM, and FM/FFM ratio. Higher TCH CDI were associated with greater FM, FMI, %FM, and FM/FFM ratio, and decreased infant FFMI. Higher lactose CDI were associated with greater FM, FMI, %FM, and FM/FFM, ratio and decreased FFMI. Concentrations and intakes of HM carbohydrates differentially influence development of infant BC in the first 12 months postpartum, and may potentially influence risk of later obesity via modulation of BC.
Manganese Uptake by A549 Cells is Mediated by Both ZIP8 and ZIP14
Authors: Scheiber Ivo F. , Alarcon Neftali Ortega , Zhao Ningning
Published: June 2019

The alveolar epithelia of the lungs require manganese (Mn) as an essential nutrient, but also provide an entry route for airborne Mn that can cause neurotoxicity. Transporters involved in Mn uptake by alveolar epithelial cells are unknown. Recently, two members of the Zrt- and Irt-like protein (ZIP) family of metal transporters, ZIP8 and ZIP14, have been identified as crucial Mn importers in vivo. ZIP8 is by far most abundantly expressed in the lungs, whereas ZIP14 expression in the lungs is low compared to other tissues. We hypothesized that Mn uptake by alveolar epithelial cells is primarily mediated by ZIP8. To test our hypothesis, we used A549 cells, a type II alveolar cell line. Mirroring the in vivo situation, A549 cells expressed higher levels of ZIP8 than cell models for the liver, intestines, and kidney. Quantification of ZIP8 and ZIP14 revealed a strong enrichment of ZIP8 over ZIP14 in A549 cells. Using siRNA technology, we identified ZIP8 and ZIP14 as the major transporters mediating Mn uptake by A549 cells. To our surprise, knockdown of either ZIP8 or ZIP14 impaired Mn accumulation to a similar extent, which we traced back to similar amounts of ZIP8 and ZIP14 at the plasma membrane. Our study highlights the importance of both ZIP8 and ZIP14 in Mn metabolism of alveolar epithelial cells.
The Association between Serum Magnesium Levels and Depression in an Adult Primary Care Population
Authors: Tarleton Emily K. , Kennedy Amanda G. , Rose Gail L. , Crocker Abigail , Littenberg Benjamin
Published: June 2019

Depression is common, places a large burden on the patient, their family and community, and is often difficult to treat. Magnesium supplementation is associated with improved depressive symptoms, but because the mechanism is unknown, it is unclear whether serum magnesium levels act as a biological predictor of the treatment outcome. Therefore, we sought to describe the relationship between serum magnesium and the Patient Health Questionnaire (PHQ, a measure of depression) scores. A cross-sectional analysis of medical records from 3604 adults (mean age 62 years; 42% men) seen in primary care clinics between 2015 and 2018, with at least one completed PHQ were included. The relationship between serum magnesium and depression using univariate analyses showed a significant effect when measured by the PHQ-2 (−0.19 points/mg/dL; 95% CI −0.31, −0.07; P = 0.001) and the PHQ-9 (−0.93 points/mg/dL; 95% CI −1.81, −0.06; P = 0.037). This relationship was strengthened after adjusting for covariates (age, gender, race, time between serum magnesium and PHQ tests, and presence of diabetes and chronic kidney disease) (PHQ-2: −0.25 points/mg/dL; 95% CI −3.33, −0.09; P < 0.001 and PHQ-9: −1.09 95% CI −1.96 −0.21; P = 0.015). For adults seen in primary care, lower serum magnesium levels are associated with depressive symptoms, supporting the use of supplemental magnesium as therapy. Serum magnesium may help identify the biological mechanism of depressive symptoms and identify patients likely to respond to magnesium supplementation.
Effect of Oral Nutritional Supplements with Sucromalt and Isomaltulose versus Standard Formula on Glycaemic Index, Entero-Insular Axis Peptides and Subjective Appetite in Patients with Type 2 Diabetes: A Randomised Cross-Over Study
Authors: Angarita Dávila Lisse , Bermúdez Valmore , Aparicio Daniel , Céspedes Virginia , Escobar Ma. , Durán-Agüero Samuel , Cisternas Silvana , de Assis Costa Jorge , Rojas-Gómez Diana , Reyna Nadia , López-Miranda Jose
Published: June 2019

Oral diabetes-specific nutritional supplements (ONS-D) induce favourable postprandial responses in subjects with type 2 diabetes (DM2), but they have not been correlated yet with incretin release and subjective appetite (SA). This randomised, double-blind, cross-over study compared postprandial effects of ONS-D with isomaltulose and sucromalt versus standard formula (ET) on glycaemic index (GI), insulin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1) and SA in 16 individuals with DM2. After overnight fasting, subjects consumed a portion of supplements containing 25 g of carbohydrates or reference food. Blood samples were collected at baseline and at 30, 60, 90, 120, 150 and 180 min; and SA sensations were assessed by a visual analogue scale on separate days. Glycaemic index values were low for ONS-D and intermediate for ET (p < 0.001). The insulin area under the curve (AUC0–180 min) (p < 0.02) and GIP AUC (p < 0.02) were lower after ONS-D and higher GLP-1 AUC when compared with ET (p < 0.05). Subjective appetite AUC was greater after ET than ONS-D (p < 0.05). Interactions between hormones, hunger, fullness and GI were found, but not within the ratings of SA; isomaltulose and sucromalt may have influenced these factors.
Phytochemicals in Prostate Cancer: From Bioactive Molecules to Upcoming Therapeutic Agents
Authors: Salehi Bahare , Fokou Patrick Valere Tsouh , Yamthe Lauve Rachel Tchokouaha , Tali Brice Tchatat , Adetunji Charles Oluwaseun , Rahavian Amirhossein , Mudau Fhatuwani Nixwell , Martorell Miquel , Setzer William N. , Rodrigues Célia F. , Martins Natália , Cho William C. , Sharifi-Rad Javad
Published: July 2019

Prostate cancer is a heterogeneous disease, the second deadliest malignancy in men and the most commonly diagnosed cancer among men. Traditional plants have been applied to handle various diseases and to develop new drugs. Medicinal plants are potential sources of natural bioactive compounds that include alkaloids, phenolic compounds, terpenes, and steroids. Many of these naturally-occurring bioactive constituents possess promising chemopreventive properties. In this sense, the aim of the present review is to provide a detailed overview of the role of plant-derived phytochemicals in prostate cancers, including the contribution of plant extracts and its corresponding isolated compounds.
Dietary Vitamin B6 Intake Associated with a Decreased Risk of Cardiovascular Disease: A Prospective Cohort Study
Authors: Jeon Jimin , Park Kyong
Published: July 2019

Although the biological mechanisms underlying the beneficial effects of vitamin B6 on cardiovascular disease (CVD) have been reported on, epidemiological studies have yielded controversial results, and data on the Korean population are limited. This study examined the association between dietary vitamin B6 intake and CVD incidence in Koreans. A total of 9142 participants of the Korean Genome and Epidemiology Study, aged 40–69 years, who did not have CVD or cancer at the baseline were included in the analysis. Dietary data were assessed using a validated semi-quantitative food frequency questionnaire. CVD incidence was assessed using biennial questionnaires and confirmed through repeated personal interviews. Multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazard regression models. After multivariate adjustment, a higher vitamin B6 intake was significantly associated with a decreased CVD risk in men (HR: 0.44; 95% CI: 0.25–0.78); no such association was observed in women. Dose-response analysis confirmed the presence of inverse linearity between vitamin B6 intake and CVD incidence in men (p for nonlinearity = 0.3). A higher dietary intake level of vitamin B6 was associated with a reduced CVD risk in Korean men. These observations require further verification in other populations.
Effect of Rice Processing towards Lower Rapidly Available Glucose (RAG) Favors Idli, a South Indian Fermented Food Suitable for Diabetic Patients
Authors: Chelliah Ramachandran , Chandrashekar Sangeeta , Saravanakumar Kandasamy , Ramakrishnan Sudha Rani , Rubab Momna , Daliri Eric Banan-Mwine , Barathikannan Kaliyan , Tyagi Akanksha , Kwame Ofosu Fred , Chen Xiuqin , Kim Se-Hun , Elahi Fazle , NaKyeong Han , Wang Myeong-Hyeon , Raman Vijaykumar , Antony Usha , Oh Deog-Hwan
Published: July 2019

The Asian food pattern primarily embraces rice and rice-based products, which mainly comprise 90% starch. Among these various food products, Idli is mostly prepared through fermentation. It has high palatability, and the rapid and highly digestible nature of the food product results in a higher post-glucose level in diabetic patients. A heat-treated Idli rice sample was prepared by roasting parboiled rice at the temperature range of 155 to 165 °C for 65 to 75 s. Idli/rice-based Dokala made from heat-treated rice is better when compared to untreated rice in terms of its microbiological profile and physiochemical properties. The proximate composition of heat-treated parboiled rice Idli/Rice Dokala showed slightly higher values than the untreated parboiled rice Idli/Rice Dokala, which reveals that it has marginally higher nutritive value. Determination of the Rapidly Available Glucose (RAG) and Slowly Available Glucose (SAG) values, SEM analysis, resistant starch analysis, microbial assay, and in vivo studies were performed to determine the glycemic index (GI) and glycemic load in normal and diabetic persons. Sensory analysis also proved that heat-treated Idli/Rice Dokala is superior to untreated based on the color, flavor, appearance, taste, and texture.
The Effects of Time Restricted Feeding on Overweight, Older Adults: A Pilot Study
Authors: Anton Stephen D. , Lee Stephanie A. , Donahoo William T. , McLaren Christian , Manini Todd , Leeuwenburgh Christiaan , Pahor Marco
Published: July 2019

A growing body of evidence indicates that time restricted feeding (TRF), a popular form of intermittent fasting, can activate similar biological pathways as caloric restriction, the only intervention consistently found to extend healthy lifespan in a variety of species. Thus, TRF may have the potential to also improve function in older adults. Given the challenges many individuals have in following calorie restriction regimens over long-time periods, evaluation of alternative approaches that may produce weight loss and improve function in overweight, older adults is important. Ten overweight, sedentary older adults (≥65 years) at risk for, or with mobility impairments, defined by slow gait speed (<1.0 m/s) participated in this trial. All participants received the intervention and were instructed to fast for approximately 16 h per day over the entire four-week intervention. Outcomes included changes in body weight, waist circumference, cognitive and physical function, health-related quality of life, and adverse events. Adherence levels were high (mean = 84%) based on days goal was met, and mean weight loss was 2.6 kg (p < 0.01). Since body composition was not measured in this study, it is unclear if the observed weight loss was due to loss of fat mass, muscle mass, or the combination of fat and muscle mass. There were no significant changes in other outcomes; however, there were clinically meaningful changes in walking speed and improvements in quality of life, with few reported adverse events. The findings of this pilot study suggest that time restricted feeding is an acceptable and feasible eating pattern for overweight, sedentary older adults to follow.
Garlic Consumption and All-Cause Mortality among Chinese Oldest-Old Individuals: A Population-Based Cohort Study
Authors: Shi Xiaoming , Lv Yuebin , Mao Chen , Yuan Jinqiu , Yin Zhaoxue , Gao Xiang , Zhang Zuofeng
Published: July 2019

In vitro and in vivo experimental studies have shown garlic has protective effects on the aging process; however, there is no evidence that garlic consumption is associated with all-cause mortality among oldest-old individuals (≥80 years). From 1998 to 2011, 27,437 oldest-old participants (mean age: 92.9 years) were recruited from 23 provinces in China. The frequencies of garlic consumption at baseline and at age 60 were collected. Cox proportional hazards models adjusted for potential covariates were constructed to estimate hazard ratios (HRs) relating garlic consumption to all-cause mortality. Among 92,505 person-years of follow-up from baseline to September 1, 2014, 22,321 participants died. Participants who often (≥5 times/week) or occasionally (1–4 times/week) consumed garlic survived longer than those who rarely (less than once/week) consumed it (p < 0.001). Participants who consumed garlic occasionally or often had a lower risk for mortality than those who rarely consumed garlic at baseline; the adjusted HRs for mortality were 0.92(0.89–0.94) and 0.89(0.85–0.92), respectively. The inverse associations between garlic consumption and all-cause mortality were robust in sensitivity analyses and subgroup analyses. In this study, habitual consumption of garlic was associated with a lower all-cause mortality risk; this advocates further investigation into garlic consumption for promoting longevity.
Entrapment of N-Hydroxyphthalimide Carbon Dots in Different Topical Gel Formulations: New Composites with Anticancer Activity
Authors: Savin Corina-Lenuta , Tiron Crina , Carasevici Eugen , Stan Corneliu S. , Ibanescu Sorin Alexandru , Simionescu Bogdan C. , Peptu Catalina A.
Published: July 2019

In the present study, the antitumoral potential of three gel formulations loaded with carbon dots prepared from N-hydroxyphthalimide (CD-NHF) was examined and the influence of the gels on two types of skin melanoma cell lines and two types of breast cancer cell lines in 2D (cultured cells in normal plastic plates) and 3D (Matrigel) models was investigated. Antitumoral gels based on sodium alginate (AS), carboxymethyl cellulose (CMC), and the carbomer Ultrez 10 (CARB) loaded with CD-NHF were developed according to an adapted method reported by Hellerbach. Viscoelastic properties of CD-NHF-loaded gels were analyzed by rheological analysis. Also, for both CD-NHF and CD-NHF-loaded gels, the fluorescence properties were analyzed. Cell proliferation, apoptosis, and mitochondrial activity were analyzed according to basic methods used to evaluate modulatory activities of putative anticancer agents, which include reference cancer cell line culture assays in both classic 2D and 3D cultures. Using the rheological measurements, the mechanical properties of gel formulations were analyzed; all samples presented gel-like rheological characteristics. The presence of CD-NHF within the gels induces a slight decrease of the dynamic moduli, indicating a flexible gel structure. The fluorescence investigations showed that for the gel-loaded CD-NHF, the most intense emission peak was located at 370 nm (upon excitation at 330 nm). 3D cell cultures displayed visibly larger structure of tumor cells with less active phenotype appearance. The in vitro results for tested CD-NHF-loaded gel formulations revealed that the new composites are able to affect the number, size, and cellular organization of spheroids and impact individual tumor cell ability to proliferate and aggregate in spheroids.
Cleavage of the Graft Bonds in PVDF–g–St Films by Boiling Xylene Extraction and the Determination of the Molecular Weight of the Graft Chains
Authors: Chen Jinhua , Seko Noriaki
Published: June 2019

To determine the molecular weight of graft chains in grafted films, the polystyrene graft chains of PVDF–g–St films synthesized by a pre-irradiation graft method are cleaved and separated by boiling xylene extraction. The analysis of the extracted material and the residual films by FTIR, nuclear magnetic resonance (NMR), and gel permeation chromatography (GPC) analyses indicates that most graft chains are removed from the PVDF–g–St films within 72 h of extraction time. Furthermore, the molecular weight of the residual films decreases quickly within 8 h of extraction and then remains virtually unchanged up to 72 h after extraction time. The degradation is due to the cleavage of graft bonds, which is mainly driven by the thermal degradation and the swelling of graft chains in solution. This allows determination of the molecular weight of graft chains by GPC analysis of the extracted material. The results indicate that the PVDF–g–St prepared in this study has the structure where one or two graft chains hang from each PVDF backbone.
Polypropylene Blend with Polyphenols through Dynamic Vulcanization: Mechanical, Rheological, Crystalline, Thermal, and UV Protective Property
Authors: Liao Jingjing , Brosse Nicolas , Pizzi Antonio , Hoppe Sandrine , Xi Xuedong , Zhou Xiaojian
Published: July 2019

Tannin and lignin were blended with polypropylene (PP) through dynamic vulcanization technique. Their influence of mechanical property, crystallinity, thermal stability, as well as ultraviolet (UV) protection property on the PP matrix was investigated and compared with native tannin and lignin. According to our experimental results, tannin and lignin undergo dynamic vulcanization and were more compatible with the PP matrix. Besides, tannin and vulcanized tannin can perform as nucleating agents of PP because of their relatively small particle size. Moreover, vulcanized tannin/lignin have a better performance on the thermal stability of PP compared with native tannin/lignin, especially PP/vulcanized lignin blend. Furthermore, vulcanized tannin/lignin present better UV protective performance, concluded from fewer changes on surface morphology, carbonyl index, crystallinity, viscosity, and tensile property.
Derivation of Vegetation Optical Depth and Water Content in the Source Region of the Yellow River using the FY-3B Microwave Data
Authors: Liu Rong , Wen Jun , Wang Xin , Wang Zuoliang , Li Zhenchao , Xie Yan , Zhu Li , Li Dongpeng
Published: June 2019

This study uses the brightness temperature at the given microwave frequency (18.7 GHz) from the Microwave Radiation Imager (MWRI) on-board the Fengyun-3B (FY-3B) satellite to improve the τ-ω model by considering the radiative contribution from waterbody in the pixels over the wetland of the Yellow River source region, China. In order to retrieve vegetation optical depth (VOD), a dual-polarization slope parameter is defined to express the surface emissivity in the τ-ω model as the sum of soil emissivity and waterbody emissivity. In the regions with no waterbody, the original τ-ω model without considering waterbody impact is used to derive VOD. With use of the field observed vegetation water content (VWC) in the source region of the Yellow River during the summer of 2012, a regression relationship between VOD and VWC is established and then the vegetation parameter b is estimated. The relationship is employed to derive the spatial VWC during the entire vegetation growing period. The VOD retrieved is invalid and failed in some part of the study area by using the previous τ-ω model, while the results from the improved τ-ω model indicate that the VOD is in the range of 0.20 to 1.20 and the VWC is in the range of 0.20kg/m2 to 1.40kg/m2 in the entire source region of the Yellow River in 2012. Both VOD and VWC exhibit a pattern of low values in the west part and high values in the east part. The largest regional variations appear along the Yellow River. The comparison between the remote-sensing-estimated VWC and the ground-measured VWC gives the root mean square error of 0.12kg/m2. These assessments reveal that with considering the fractional seasonal wetlands in the source region of the Yellow River, the microwave remote sensing measurements from the FY-3B MWRI can be successfully used to retrieve the VWC in the source region of the Yellow River.
The Integration of Multi-source Remotely-Sensed Data in Support of the Classification of Wetlands
Authors: Judah Aaron , Hu Baoxin
Published: June 2019

Wetlands play a key role in regional and global environments, and are critically linked to major issues such as climate change, wildlife habitat, biodiversity, water quality protection, and global carbon and methane cycles. Remotely-sensed imagery provides a means to detect and monitor wetlands on large scales and with regular frequency. In this project, methodologies were developed to classify wetlands (Open Bog, Treed Bog, Open Fen, Treed Fen, and Swamps) from multi-source remotely sensed data using advanced classification algorithms. The data utilized included multispectral optical and thermal data (Landsat-5) and Radar imagery from RADARSAT-2 and Sentinel-1. The goals were to determine the best way to combine the aforementioned imagery to classify wetlands, and determine the most significant image features. Classification algorithms investigated in this study were Naive Bayes, K-Nearest Neighbor (K-NN), Support Vector Machine (SVM), and Random Forest (RF). Based on the test results in the study area in Northern Ontario, Canada (49°31′.34N, 80°43′37.04W), a RF based classification methodology produced the most accurate classification result (87.51%). SVM, in some cases, produced results of comparable or better accuracy than RF. Our work also showed that the use of surface temperature (an untraditional feature choice) could aid in the classification process if the image is from an abnormally warm spring. This study found that wetlands were best classified using the NDVI (Normalized Difference Vegetative Index) calculated from optical imagery obtained in the spring months, radar backscatter coefficients, surface temperature, and ancillary data such as surface slope, computed through either an RF or SVM classifier. It was also found that preselection of features using Log-normal or RF variable importance analysis was an effective way of identifying low quality features and to a lesser extent features which were of higher quality.
A Survey of Mobile Laser Scanning Applications and Key Techniques over Urban Areas
Authors: Wang Yanjun , Chen Qi , Zhu Qing , Liu Lin , Li Chaokui , Zheng Dunyong
Published: June 2019

Urban planning and management need accurate three-dimensional (3D) data such as light detection and ranging (LiDAR) point clouds. The mobile laser scanning (MLS) data, with up to millimeter-level accuracy and point density of a few thousand points/m2, have gained increasing attention in urban applications. Substantial research has been conducted in the past decade. This paper conducted a comprehensive survey of urban applications and key techniques based on MLS point clouds. We first introduce the key characteristics of MLS systems and the corresponding point clouds, and present the challenges and opportunities of using the data. Next, we summarize the current applications of using MLS over urban areas, including transportation infrastructure mapping, building information modeling, utility surveying and mapping, vegetation inventory, and autonomous vehicle driving. Then, we review common key issues for processing and analyzing MLS point clouds, including classification methods, object recognition, data registration, data fusion, and 3D city modeling. Finally, we discuss the future prospects for MLS technology and urban applications.
Evaluation of Vegetation Biophysical Variables Time Series Derived from Synthetic Sentinel-2 Images
Authors: Djamai Najib , Zhong Detang , Fernandes Richard , Zhou Fuqun
Published: July 2019

Time series of vegetation biophysical variables (leaf area index (LAI), fraction canopy cover (FCOVER), fraction of absorbed photosynthetically active radiation (FAPAR), canopy chlorophyll content (CCC), and canopy water content (CWC)) were estimated from interpolated Sentinel-2 (S2-LIKE) surface reflectance images, for an agricultural region located in central Canada, using the Simplified Level 2 Product Prototype Processor (SL2P). S2-LIKE surface reflectance data were generated by blending clear-sky Sentinel-2 Multispectral Imager (S2-MSI) images with daily BRDF-adjusted Moderate Resolution Imaging Spectrometer images using the Prediction Smooth Reflectance Fusion Model (PSFRM), and validated using thirteen independent S2-MSI images (RMSE ≤ 6%). The uncertainty of S2-LIKE surface reflectance data increases with the time delay between the prediction date and the closest S2-MSI image used for training PSFRM. Vegetation biophysical variables from S2-LIKE products are validated qualitatively and quantitatively by comparison to the corresponding vegetation biophysical variables from S2-MSI products (RMSE = 0.55 for LAI, ~10% for FCOVER and FAPAR, and 0.13 g/m2 for CCC and 0.16 kg/m2 for CWC). Uncertainties of vegetation biophysical variables derived from S2-LIKE products are almost linearly related to the uncertainty of the input reflectance data. When compared to the in situ measurements collected during the Soil Moisture Active Passive Validation Experiment 2016 field campaign, uncertainties of LAI (0.83) and FCOVER (13.73%) estimates from S2-LIKE products were slightly larger than uncertainties of LAI (0.57) and FCOVER (11.80%) estimates from S2-MSI products. However, equal uncertainties (0.32 kg/m2) were obtained for CWC estimates using SL2P with either S2-LIKE or S2-MSI input data.