bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical profile, cardiac involvement and outcome of children admitted with sepsis in pediatric intensive care unit at GB Pant children hospital Srinagar
Authors: Khan Younus Ramzan , Kasana Sarafraz Ahmad , Din Asif Mohi Ud , Jan Muzafar , Mehraj Junaid
Published: May 2023

Background: Sepsis is a systemic illness caused by an infectious agent invading the body, which induces the release of inflammatory mediators, resulting in systemic inflammatory response syndrome (SIRS). The aim of our study was to recognize clinical profile, cardiac involvement, laboratory work up, etiology, treatment, and immediate outcome of patients admitted with sepsis.
Methods: This prospective observational study was conducted in pediatric intensive care unit over period of two years. After informed consent from parents, all those patients meeting inclusion criteria were subjected to complete history, general and systemic physical examination. Routine baseline investigations included CBC, LFT, KFT, ABG, chest X-ray, serum calcium and phosphorous were done in all patients. The other investigations like echocardiography, COVID-19 RAT and RTPCR, CSF, blood and urine culture, USG, CT, MRI and various inflammatory markers like serum ferritin, CRP and ESR whenever required were done.
Results: In this study 35 patients aged 1 year to 18 years with a diagnosis of sepsis were included. Out of them 20 were males and 15 were females with a male female ratio of 1.3:1 and mean age of 6.2 years. The most common etiology for sepsis was severe pneumonia seen in 17 (48.5%) cases while 8 (22.9%) had osteomyelitis, 3 (8.6%) had urinary tract infection, 2 (5.7%) had meningoencephalitis, 2 (5.7%) had severe diabetic ketoacidosis with culture proven sepsis, 2 (5.7%) had gastrointestinal infection and 1 (2.86%) had iliopsoas abscess with liver abscess. On echocardiography 9 (25.7%) patients had left ventricular (LV) dysfunction with left ventricular ejection fraction (LVEF) less than 55% and 3 (8.6%) patients had pericardial effusion. Out of them 20 (57%) patients were discharged after 8.9 days mean duration of hospital stay and 15 (43%) patients got expired after 3.1 days mean duration of hospital stay.
Conclusions: Severe sepsis with septic shock is the leading cause of mortality if not picked early and treated aggressively.
Clinical profile and outcome of multisystem inflammatory syndrome in children and adolescents related to COVID-19 in a tertiary care hospital
Authors: Mistry Shreyaben M. , Buch Kathan P. , Buch Pankaj M.
Published: May 2023

The pandemic of COVID-19 initially appeared to cause only a mild illness in children. The paediatric age group comprises only less than 7% of total COVID-19 worldwide. Multi system inflammatory syndrome in children (MIS-C) is a rare, but life-threatening complication of SARS-CoV-2 infection. We report a case series of 24 children with suspicion of multisystem inflammatory syndrome related to COVID-19 were assessed using diagnostic criteria established by ministry of health and family welfare, government of India using detailed history, clinical examination and relevant laboratory investigations. Among total 24 patients ranging from 23 days to 11 years with mean age of 4.5 years includes 10 patients (41.67%) presented with mild illness, 7 patients (29.12%) with persistent fever to Kawasaki disease (KD) like illness and 7 patients (29.12%) with fatal disease with MODS and shock. These children were managed as per guidelines with modifications for individual case if necessary and includes supportive management with main stays of IVIG and steroids. Three children died.
Glanzmann’s thrombasthenia: a rare case presented with recurrent nasal bleeding
Authors: Kumbhar Suhas G. , Swami Shivling S. , Khapra Kashvi
Published: May 2023

A rare congenital condition of platelet aggregation known as Glanzmann's thrombasthenia is caused by mutations in the Glycoprotein IIb or Glycoprotein IIIa gene, which leads to platelet malfunction. Glanzmann’s thrombasthenia is difficult to diagnose on basis of routine physical examination and is usually mis diagnosed because platelet morphology is normal as well as the platelet counts are in normal range, but bleeding duration is noticeably longer. The most prevalent signs of Glanzmann’s thrombasthenia include numerous types of bleeding, such as menorrhagia in females, recurrent nasal bleeding, mucocutaneous haemorrhage, continuous bleeding after injury or surgery, etc.   Recurrent severe intractable causes of massive nasal epistaxis are relatively less common, particularly in cases where local causes do not explain the findings, then haematological causes should be suspected. Here we present a case of a 3 years old Indian boy who presented with recurrent massive epistaxis, fatigue, severe anaemia, and breathlessness who was diagnosed with Glanzmann’s thrombasthenia upon undergoing various investigations such as genetic testing and platelet assays. The patient was immediately started with supportive treatment and progress was made by the patient. Counselling was done to the patient’s family that it is a lifelong disorder and upon taking prescribed treatment bleeding episodes will be reduced. Overall Glanzmann’s thrombasthenia is a lifelong disorder which is difficult to diagnose, and misdiagnosis is very common regarding this disease, hence the clinician should remain alert regarding this rare congenital disorder and appropriate lab investigations should be done and treatment must be started in due time.
A prisão preventiva nos crimes econômicos
Authors: Chiquini Jeffrey , Gunther Luiz Eduardo , Bonner Cochran III Augustus
Published: May 2023

Objetivos: Tendo no ordenamento jurídico as hipóteses que autorizam a prisão preventiva e a sua necessidade concreta, o presente artigo tem como objetivo geral, analisar a prisão preventiva nos crimes econômicos à luz da lei, da doutrina e da jurisprudência brasileira, enquanto prisão cautelar de natureza processual, para garantir a ordem econômica. Metodologia: Para a pesquisa utilizou-se o método analítico-descritivo na abordagem dos temas relacionados ao objeto do estudo, bem como a pesquisa em doutrinas, artigos científicos e em decisões judiciais. Resultados: A prisão preventiva como garantidora da Ordem Econômica, segundo a nova redação do Código de Processo Penal, é um instrumento importante e necessário a serviço da consecução da eficácia do processo penal nos casos de crimes econômicos. Esses crimes não são violentos, mas seus efeitos sociais são nefastos e atingem uma grande gama de pessoas, porque o bem jurídico que se protege é metaindividual. Além disso, o crime econômico configura uma ruptura da Ordem Constitucional e atinge diretamente o desenvolvimento econômico do país, devendo ser combatido pronta e eficientemente. Para isso, se o imputado oferecer risco à investigação ou ao processo, e em não havendo outras medidas cautelares restritivas de liberdade capazes de refrear a lesividade de sua conduta, deve ser decretada sua prisão preventiva. Contribuições: A necessidade concreta da prisão preventiva, enquanto prisão cautelar de natureza processual, para garantir a ordem econômica, deve ser obtida por meio da imputação de condutas a ela ofensivas, porque a ordem econômica deve ser considerada uma fração da ordem jurídica. Logo, atos praticados contra a ordem econômica são atos praticados contra a ordem jurídica, nos exatos termos das categorias contidas e descritas pelas leis que as compõem e, portanto, tais leis devem ser rigorosamente aplicadas, especialmente quando os fatos estão sendo tratados no campo jurídico-penal, no qual não se admite interpretações extensivas, por força da regra fundamental do Estado de Direito de que as leis penais só admitem interpretação taxativa e restritiva.
Avaliação da presença de sintomas de LER/DORT em funcionários do sistema elétrico
Authors: Medeiros Lavoisier Morais de , Silva Dlânio Gabriel Figuerêdo , Silva Denise De Figuerêdo , Santos Carla Galdino Costa dos
Published: May 2023

As LER/DORT são um conjunto de doenças que afetam os tecidos do corpo sendo ou não de origem ocupacional, sendo que, atualmente o Brasil apresenta uma elevada incidência desses distúrbios, assumindo um caráter epidêmico. Neste sentido foi realizado um estudo que objetivou verificar a presença de sintomas de LER/DORT em funcionários do sistema elétrico da cidade de Cajazeiras-PB. A amostra foi composta 24 indivíduos sendo dezenove homens e cinco mulheres. A coleta de dados ocorreu no mês de março de 2009 sendo utilizado um questionário contendo questões sócio demográficas e também referentes às queixas relacionadas as LER/DORT. Os dados foram analisados de forma descritiva simples, relacionando às informações obtidas a luz da literatura pertinente. Os resultados obtidos revelam maior predominância de dores na região da coluna cervical e lombar, fato esse que pode ser explicado ao somatório de vários fatores de risco podendo ser destacada a postura em pé e sentada adotadas pelos indivíduos durante o trabalho, demonstrando que as doenças ocupacionais comprometem a produtividade do trabalhador.
Manifestações patológicas em revestimentos cerâmicos de fachadas: o caso do edifício-sede da Justiça Eleitoral da Paraíba
Authors: Costa Alexandre Kelly De Oliveira , Meira Alexsandra Rocha
Published: May 2023

O estudo dos defeitos e vícios construtivos tem importância pela contribuição que pode dar para a melhoria contínua no desempenho e na durabilidade das edificações, uma vez que a busca das origens e causas de manifestações patológicas de caráter construtivo é fundamental para intervenções efetivas e duradouras nas mesmas. [...].
Análise de convecção forçada interna: solução via transformada integral e computação simbólica
Authors: Santos Jacques Cesar Dos , Veronese Jean Pierre
Published: May 2023

No presente trabalho um estudo teórico da convecção forçada interna em um canal de placas placas paralelas é apresentado. [...].
Dermatitis Atopic and Psoriasis Skin Disease Classification by using Convolutional Neural Network
Authors: Sari Dwi Mei Rita , Nurmaini Siti , Rini Dian Palupi , Sapitri Ade Iriani
Published: May 2023

Skin is the one of the body parts that play a large role in human physical body. There are so many functions of the skin such as offering protection against fungal infection, bacteria, allergy, viruses and controls the temperature of the body. But, the reported shown that the skin disease is the most common disease in humans among all age groups and a significant root of infection. The diagnosis of skin diseases involves several tests. Due to this, the diagnosis process is seen to be intensely laborious, time-consuming and requires an extensive understanding aspecially for the skin disease that have similar symptoms. Two skin diseases that have similar symptoms and most misdiagnosed are atopic dermatitis and psoriasis. Convolutional Neural Network for image processing and classifying have been developed for more accurate classification of skin diseases with different architectures. However, the accuracy in determining skin lesions using CNNs is on the average level. The factors that affect the accuracy result of a CNN is the depth where gradients vanished as the network goes deeper. Another factor is the variance in the training set which means the need of the large size of training set. Hence, in this study we tried 10 CNN architecture to get the best result for classifying dermatitis atopic and psoriasis. These are VGG 16, VGG 19, ResNet 50, ResNet 101, MobileNet, MobileNet V2, DenseNet 121, DenseNet 201, Inception and Xception. Experimental result shown that the inception V3 architecture give the best result with accuracy for data testing 84%, accuracy for unseen data 82% and confusion matrix with True positive obtained is 248, True Negative is 61, False positive is 54 and False Negative 298.
The influence of evening walks on the emotional state of students
Authors:   Northern State Medical University, Polunina Victoria N. , Tsinis Aleksey V. ,   Northern State Medical University
Published: May 2023

The problem of creating harmony in relation to the mental and physical health of students at present is quite serious. Modern medical universities are characterized by an intellectual overload in conditions of insufficient physical activity, which necessitates increasing the stress resistance of the students’ organism. The means of physical activity used to reduce stress vary for different groups of people. The relevance of the study issue is due to thefact that evening walks are suitable for people of any age, including students, and have no contraindications. The purpose of the study is to compare the indicators of the emotional state and quality of sleep of the students who take daily evening walks in the fresh air, and the indicators of their peers who prefer spending time at home. It is assumed that students who combine physical activity in the elective classes of physical education and sports with daily walks have higher rates of emotional state and sleep quality than their peers who do not use physical activities in their free time. The study involved 180 students of the Northern State Medical University. The analysis of the emotional state of students was carried out according to the method of L. A. Kurgansky and T. A. Nemchina. According to the results of the survey, students who take evening walks have higher indicators of emotional state than those who prefer spending time at home. To study sleep indicators, a questionnaire for scoring the quality of sleep by Y. I. Levin was used. According to the results of the survey, students who take evening walks have higher rates of sleep quality. The conducted studies have shown that the means of physical education can optimize the emotional state of students, reduce anxiety, tension and discomfort. The study proves the importance of systematic exercises, even of the easiest and the most accessible ones, such as evening walks in the fresh air.
Pluralistic Ignorance and Non-Use of Modern Contraceptives in Southwestern Nigeria: A Qualitative Study Using the Social Norms Theory
Authors: Binuyo Olutomiwa A.
Published: May 2023

Background: The 2018 National Demographic Health Survey (NDHS) revealed that out of the current non-users of contraceptives amongst married women, only 38% of them made their own decision to abstain. The remaining 62% either decided jointly with their partner or the partner solely decided for them. This elicits the notion that social expectations within reference networks could influence the use of modern contraceptives (MCs) in Nigeria.
Methods: 16 structured qualitative interviews were used to gather the beliefs, attitudes and social expectations of the respondents as regards the non-use of MCs between March and June 2020. Through snowballing sampling method, residents in the Ibadan Metropolis, southwest Nigeria responded to the hypothetical scenarios presented by the vignettes during interviews. Data were analysed using the Social Norms Analysis Plot framework. This framework serves as the checklist for the reporting of findings.  Basic ethical principles were upheld throughout the study.
Results: Seven categories and five main themes emerged from this study. These categories include gender norms, social influence, peer pressure, myths, misconceptions, awareness and pluralistic ignorance. The themes were generated using the Social Norms Analysis Plot framework and they include empirical expectation, normative expectations, sanctions, sensitivity to sanctions and exceptions. The majority of the respondents strongly believe that most women in their community will not use contraceptives simply because of their male partners and friends. Out of those who do not use MCs due to social expectations, it was seen that the majority personally support its use.
Conclusion: To promote the uptake of modern contraceptive use in Southwest Nigeria, it is important to update people’s social expectations. The findings of these study studies are relevant for policymakers and civil society organizations in designing effective intervention reproductive health programs in different regions of Nigeria (especially areas of lower use of modern contraceptives).
Investigating the Relationship between Organizational Atmosphere and Tendency to Leave Jobs and Fear of COVID-19 in Health Team Members of Health Centers In 2021
Authors: Saljoghi Ali , Karimiankakolaki Zohreh
Published: May 2023

Background: Today, we are facing the spread of the COVID-19 epidemic and its undesirable effects on healthcare providers. This study aims to investigate the relationship between the organizational atmosphere and the tendency to leave jobs and fear of covid-19 in health team members of health centers in 2021.
Methods: In this descriptive-analytical study, 120 personnel working in the health network headquarters and health centers of Koohrang city of Chaharmahal and Bakhtiari province were selected by census and studied as health team members. After explaining the objectives of the research and completing informed consent by participants, the organizational atmosphere questionnaire, the tendency to leave jobs questionnaire, and the fear of COVID-19 questionnaire are completed. Finally, collected data are analyzed via SPSSv21, descriptive tests, and T-tests.
Results: Average score and standard deviation of research variables for organizational atmosphere, leave job tendency, and fear of COVID-19 are obtained as 3.48 ± 0.59 (Above average), 3.81 ± 0.68 (Above average), and 2.14 ± 0.90 (Below average), respectively. The mediating variable of COVID-19 fear was not have a significant effect on the tendency of personnel to leave their jobs based on the organizational atmosphere (P = 0.109). Between the organizational atmosphere and leaving the job there was a direct relationship and meaningful (P=0.005). Between the organizational atmosphere and fear of COVID-19, there are indirect relationships and meaningful (P =0.008). But, there was no evidence of a significant relationship between the tendency to quit and the employees' fear of COVID-19 (P = 0.140).
Conclusion: According to the results, there is a favorable organizational atmosphere, but the desire to leave the job is high among them, although the fear of Covid-19 does not play a mediating role in this desire to leave the job. The results of this study can be used in management planning.
Effect of Multisensory Stimulation on the Physical Growth of Premature Infants
Authors: Nasimi Fatemeh , Norouzi Tabar Mohammad
Published: May 2023

Introduction: Height and head circumference is one of the criteria for physical health of preterm infants and indicates their neuromuscular development. The aim of this study was to investigate the effect of multisensory stimulation on height and head circumference of preterm infants.
Methods: The present study was a clinical trial study; which was performed on premature infants admitted to the neonatal intensive care unit at Shahid Motahari Hospital in Jahrom City, Iran, in 2016. Initially, 80 infants with a gestational age of 32 to 36 weeks were randomly divided into two groups of multisensory stimulation and control. The intervention method in this study was that the intervention group had a multisensory stimulation program (auditory stimulation, tactile stimulation, visual stimulation and vestibular stimulation) by mothers for 12 minutes per day and 5 times a week until discharge and in the control group they only received the usual care ward. The height and head circumference were measured by the researcher with a meter until the day the infant was discharged from the ward. Data were analyzed using SPSS software version 16.
Results: There was no significant difference between the two groups of preterm infants in terms of fetal age, birth weight and sex. Based on the comparison between groups, a significant difference was observed in the two groups in terms of height and head circumference (P <0.001).
Conclusion: The findings of this study show that multisensory stimulation affects the physical development of premature infants.
Mapeamento dos trabalhos de conclusão do curso de licenciatura em Física da Universidade Federal do Triângulo Mineiro
Authors: De Oliveira José Constâncio , Leite Danielle Aparecida Reis
Published: May 2023

O curso de Licenciatura em Física da Universidade Federal do Triângulo Mineiro (UFTM) teve início no ano de 2009 e a primeira turma concluiu a graduação em 2013. Em 2019, o curso completou dez anos de existência e totalizou 51 formados. Com isso, realizamos uma pesquisa que reuniu e analisou os Trabalhos de Conclusão de Curso (TCC) produzidos nesse curso. Assim, o objetivo geral do trabalho é mapear e analisar os TCC do curso de Licenciatura em Física da UFTM, a fim de discutir as possibilidades oferecidas pelo referido curso para o desenvolvimento de Pesquisas de Conclusão de Curso, além de analisar as contribuições dessas pesquisas para a formação do futuro professor de Física. Trata-se de uma pesquisa qualitativa, de natureza documental, realizada em etapas que envolvem a leitura e desmembramento desses textos. Os dados obtidos evidenciam que os TCC analisados estão distribuídos em três áreas do conhecimento, possuem objetivos e metodologias diversificadas, e reforçam a ideia de que o Curso de Licenciatura em Física da UFTM oferece ao aluno diversas possibilidades para a realização de seu TCC, além de contribuírem para a formação do professor de Física.
Objetos de Aprendizagem Interativos
Authors: Alves Cardoso Cristiane , Lemos de Almeida Luana , de Magalhães Dantas Neto Renato , Pereira Calazans Renato
Published: May 2023

Em 2019 o distanciamento social foi implementado como medida de proteção contra a disseminação da COVID-19. Desta forma, as aulas passaram a ocupar o espaço virtual, sendo a internet uma aliada na construção do conhecimento, onde a interação entre os envolvidos no ensino-aprendizagem é critério fundamental. Este artigo tem por objetivo investigar a criação e uso dos Objetos de Aprendizagem Interativos (OAI) por professores brasileiros no primeiro bimestre de 2022. Com uma metodologia de pesquisa descritiva-exploratória, chegou-se à conclusão de que, apesar da boa aceitação dos OAI na prática pedagógica, a ampliação de seu uso esbarra na deficiência de conhecimentos tecnológicos e falta de tempo dos professores.
Il ruolo dei verba ‘nisi restituent’ nella promessa dell’actio de recepto
Authors: Calore Emanuela
Published: May 2023

El artículo tiene como objetivo reflexionar sobre el papel de las palabras ‘nisi restituent’ en la cláusula edictal referida por Ulpiano en 14 ad ed. D. 4.9.1pr., con la cual el pretor prometía la concesión de una actio de recepto. Más específicamente, el artículo se pregunta, también sobre la base de otras fuentes (incluyendo, en particular, Ulp. 14 ad ed. D. 4.9.3.5 y Ed. Theod. 119), si la fórmula de la actio de recepto contenía una cláusula restitutoria y, en caso afirmativo, cuáles podrían haber sido las implicaciones de tal presencia, tanto desde la perspectiva del empresario como desde la del cliente.
Automation in Investment Advice. A European Perspective
Authors: Rinaldo Carlotta
Published: May 2023

El presente artículo investiga cómo se encuadra el asesoramiento de inversión automatizado (también llamado asesoramiento robótico) en el actual marco regulatorio europeo. Desde el punto de vista de un jurista europeo se describe y define el fenómeno, destacando sus beneficios y riesgos potenciales, y delineando los principales modelos de negocio en el mercado. Analiza los retos que implica la aplicación del régimen Mifid II, especialmente en el ámbito de la protección de los inversores.
PSORÍASE INVERTIDA E O ATRASO DIAGNÓSTICO: UM RELATO DE CASO
Authors: Bento de Oliveira Nicole , Oliveira de Carvalho Murilo , Bento de Oliveira Letícia , Dos Santos Back João Vitor , Wessler Faust Leila
Published: May 2023

Não há necessidade de resumo para relato de experiência.
FATORES DE RISCO E FATORES PROTETORES PARA O DESENVOLVIMENTO DE MASTITE PUERPERAL: UMA REVISÃO INTEGRATIVA
Authors: Brasil de Freitas Taynara , Perdoná da Silveira Maria Heloísa , Zanette Naspolini Maria Laura , Santana Mendes João Vítor , Scheeren Xavier Maria Eduarda , Hilário Pinter Paulo Otávio , Ceolin de Jesus Laura , Ferreira Gomide Gabriela , Laurentino Jesuino Mariani
Published: May 2023

RESUMO:

Mastite puerperal é uma condição inflamatória da glândula mamária bastante associada ao período de lactação seguida de um estágio não infeccioso para uma mastite infecciosa. O trabalho objetivou delimitar os fatores associados a maior e menor propensão de mastite no puerpério, através de uma revisão de literatura realizada nas base de dados PubMed, Cochrane e Biblioteca Virtual em Saúde, com os descritores "mastitis”, "puerperal mastitis" e “breast infection after childbirth”. Artigos incompatíveis com o objetivo foram excluídos e foram selecionados artigos entre 2015 e 2021. É comum ocorrer nas primeiras seis a oito semanas de pós-parto. Foram identificados 42 fatores de risco potenciais divididos em três categorias: relacionados aos comportamentos, relacionadas às características maternas e relacionadas ao puerpério, sendo a lesão mamilar o principal. Práticas como aumentar a frequência das mamadas, alternar as mamas em que se inicia a amamentação e autocuidado das mamas após o aleitamento diminuem p risco da patologia. Fica explícito que grande parcela dos fatores de risco e protetores para mastite são comportamentais, logo sendo possível modificá-los para que haja uma diminuição progressiva da sua incidência.

PALAVRAS CHAVES: Mama; Mastatis; Fatores de Risco; Período Pós-Parto; Doenças Mamárias.
saúde nos municípios amazonenses no período 2013-2018:
Authors: Freitas Iuri , Santos Andreia
Published: May 2023

Avaliar a distribuição do gasto público com saúde é importante para embasar o planejamento da oferta das ações e serviços de saúde, permitindo que a sua alocação seja realizada de forma maximizar o atendimento das demandas da população. Objetivou-se avaliar a distribuição do gasto público com saúde (GPS) nos municípios do estado do Amazonas, no período 2013-2018. A análise foi feita por meio da avaliação da distribuição do gasto público com saúde per capita, da relação entre o gasto público com saúde e a renda gerada nos municípios e da evolução do gasto público diante do crescimento populacional Constatou-se um cenário de desigualdade na distribuição do GPS tanto na distribuição por município, quanto na distribuição por Região de Saúde. A tendência do gasto público divergiu entre os municípios, sendo os de maior porte os que tiveram a maior participação no GPS, mas apresentaram queda no GPS entre 2013 e 2018. Já os municípios de pequeno porte tiveram baixa participação no GPS.
Determination of the Levels of Selected Heavy Metals in Finger Millet (Eleusine coracana) Flour in West Gojjam Zone, Amhara Region
Authors: Fetene Desalegn , Lelago Alemu , Bibiso Mesfin , Bosha Abraham
Published: May 2023

Background: Finger millet is a native and indigenous food crop in Ethiopia and has been cultivated in different parts of the country for centuries. However, its heavy metal contents in other parts of Ethiopia were not well studied, especially in the study area. The study was conducted in the Mankussa and Finoteselam district of the western Gojjam zone, Amhara region Ethiopia, to determine the heavy metal (Mn, Fe, Zn, Cu and Pb) levels of finger millet by using inductively coupled plasma optical emission spectroscopy. Methods: A wet digestion procedure was developed using a mixture of HCl, HNO3 and H2O2 to decompose a mixed powdered finger millet sample. Result: Mn, Fe, Cu, Zn and Pb mean levels were 3.751, 1.699, 0.072, 0.4485 and 0.024 mg/L, respectively, in Mankussa Black finger millet samples. In Mankussa mixed finger millet, the mean metal levels were 3.573 mg/L, 2.7585 mg/L, 0.0585 mg/L, 0.799 mg/L and 0.024 mg/L for Mn, Fe, Cu, Zn and Pb, respectively and the mean metal levels of Mankussa White Finger millet were found to be 2.326, 2.289, 0.045, 0.5985 and 0.014 mg/L of Mn, Fe, Cu, Zn and Pb respectively. While the mean metal level of Finoteselam black Finger millet samples was found to be 5.651 mg/L, 2.1955 mg/L, 0.0435 mg/L, 0.744 mg/L and 0.011 mg/L for Mn, Fe, Cu, Zn and Pb respectively, in the mixed finger millet it was 3.023 mg/L, 2.155 mg/L, 0.0525 mg/L,1.259 mg/L of Mn, Fe, Cu and Zn. In white finger millet, it was found to be 2.8695 mg/L, 1.412 mg/L, 0.0525 mg/L and 1.0735 mg/L of Mn, Fe, Cu and Zn. Pb was not detected by the instrument in Finoteselam mixed and white finger millet samples. The metal levels investigated in this study were comparable with international standards.
Quality Evaluation and Consumer Acceptance Test of Functional Fruit-herb Beverages
Authors: Sahrawat Neha , Chaturvedi Neelam
Published: May 2023

Background: Functional beverages are one of the kind that focuses solely on consumer interest in health and have distinctive formulations made up of different herbal ingredients along with fruits/vegetables blended together to meet the optimum outcomes. The purpose of the present paper is quality evaluation and organoleptic acceptability which is identified as a significant predictor. Methods: The developed functional fruit-herb beverages produced from Wheatgrass, Pomelo fruit and Hibiscus flower in addition to one each from six treatments of different proportions were analyzed for consumer acceptance test along with chlorophyll, carotenoids, total Phenolic contents, flavonoids content and DPPH radical scavenging activity. Result: The consumer’s overall acceptability of the beverages one serving portion (200 ml) was significantly correlated to their taste and flavor and consumer preference on taste. Beverage (T2) was most preferred, but beverage T2 was favored by one group while beverage (T3) was chosen by the second group. This study examined the chemical characteristics of functional fruit-herb beverages and its conclusions imply that changing the proportions of the ingredients will change the optimal beverage blend’s nutrient profile. Hibiscus juice in T5 and T2 at higher ratios greatly enhanced the formulation’s antioxidant response. While the level of chlorophyll and carotenoids considerably rose in T6 and T3 as the ratio of wheatgrass juice increased.
PENINGKATAN SUMBER DAYA MAHASISWA DENGAN KOMUNIKASI DAN PUBLIC SPEAKING GUNA MENCETAK GENERASI YANG MAMPU MEWUJUDKAN SUSTAINABLE DEVELOPMENT GOALS
Authors: Dewi Almas Farah Dinna , Krishnabudi Nyoman Gede , Kumalasari Dewi Shinta
Published: May 2023

Kemampuan komunikasi dan berbicara di depan umum dapat dipahami sebagai teknik untuk menyampaikan pesan kepada khalayak lain dan di depan banyak audiens. Kemampuan ini menjadi dasar kesuksesan setiap orang di berbagai bidang. Dengan komunikasi yang baik, seseorang memiliki nilai tambah untuk menjadi insan yang cerdas, visioner, inovatif dan dedikatif. Tujuan pengabdian masyarakat ini adalah untuk memberikan bekal kemampuan dan keterampilan tentang komunikasi dan public speaking dasar khususnya dalam hal ini mahasiswa sebagai generasi muda yang berdomisili di Jember. Hal ini diperlukan untuk memberikan nilai tambah kepada para generasi muda yang menjadi bagian untuk mewujudkan Sustainable Development Goals (SDGs) yang telah dicanangkan pada era saat ini. Metode pelaksanaan pengabdian yang dilakukan pada program pengabdian kepada masyarakat ini dilakukan melalui 3 tahapan, yaitu: metode pelatihan, pendampingan dan evaluasi. Hasil pelatihan berdasarkan kuesioner umpan balik yang telah diisi yakni peserta merasa sangat puas dengan pelatihan dan pendampingan yang telah dilaksanakan dan berharap bisa dilaksanakan lebih lanjut ke depannya karena memberi manfaat dan pengalaman yang luar biasa.
Bottom/top hardness ratio and dentin bonding stability of conventional and bulk-fill resin composites
Authors: Marinho Maria Eduarda Lima do Nascimento , Sousa-Lima Rodolfo Xavier de , Chaves Letícia Virgínia de Freitas , Borges Boniek Castillo Dutra
Published: May 2023

Aim: To evaluate the bottom/top hardness ratio (B/T) and the dentin bonding stability of conventional and bulk-fill resin composites in high c-factor preparations. Methods: Regular conventional (Tetric N-Ceram – TNC, and Polofil Supra – PFS), regular bulk-fill (Tetric N-Ceram Bulk fill – TBF, and Admira Fusion X-tra – AFX), and low viscosity bulk-fill resin composites (Tetric N-flow – TNF, and X-tra Base – XTB) were used to restore 180 dentin conical preparations. The specimens were randomly distributed in 12 groups (n = 15) according to the resin composites and storage time-points (24 h and six months) tested. After 24 h storage, all specimens were subjected to the bottom/top hardness ratio analysis. Then, the push-out bond strength test was performed in half of the specimens and the other half were maintained for six months on water storage before testing. The failure modes were analyzed in a stereomicroscopic. The data were analyzed statistically using one- and two-way ANOVA and Tukey post-test (p <0.05). Results: There were no statistically significant differences for the bottom/top hardness ratio among the resin composites (p>0.05). Regardless of the storage timepoint, regular bulk-fill resin composites showed the highest bond strength values statistically (p<0.05). Only conventional resin composites showed statistically lower bond strength values at six-month storage (p<0.05). Adhesive failures were more predominant for low-viscosity bulk-fill resin composites. Conclusion: Although the DoC was not affected by different materials tested, only bulk-fill resin composites did not present dentin bond strength loss after six-month of water storage.
A representação científica a partir das “Analogias da experiência” de Kant
Authors: Oliveira Bruno Camilo de
Published: May 2023

O objetivo deste artigo é abordar a maneira como Kant considera as “analogias da experiência” ligações necessárias para ocorrer a representação científica do mundo físico. O método consiste em analisar trechos selecionados da Crítica da razão pura, sobretudo do texto “Analítica dos princípios”, que apresentem as analogias da experiência como regras que determinam as ligações necessárias entre as percepções e a capacidade de compreensão dos fenômenos. Kant argumenta que embora os objetos sejam em si mesmos inacessíveis a nós isto não implica a impossibilidade de pensarmos neles. O resultado é uma perspectiva sobre o conhecimento científico capaz de considerar as analogias da experiência para manter alguns conceitos a priori sobre o mundo físico.
Complex pathogens in infective endocarditis
Authors: Escolà-Vergé Laura , Roque Albert , Pizzi María Nazarena , González-López Juan José , Almirante Benito , Fernández-Hidalgo Nuria
Published: May 2023

Infective endocarditis (IE) is a complex disease whose prognosis depends on the causative microorganism, among other factors. The latter can be difficult to identify and/or treat. In this narrative review, we identify knowledge gaps in the diagnosis and antimicrobial treatment of IE, and attempt to shed light on current questions. Specifically, we: (1) analyze the factors that may hinder the microbiological diagnosis of blood culture-negative IE, as well as the role of new imaging techniques, such as 18F-fluorodeoxyglucose ([18F]FDG PET/CT), in the diagnostic capacity of this disease, understanding their advantages and assuming their limitations; (2) discuss the therapeutic approach to various difficult-to-treat microorganisms. In particular, we focus on the treatment of staphylococcal IE since, at present, staphylococci are the most frequent cause of IE in developed countries and staphylococcal IE is one of those with the highest short- and long-term mortality. We critically evaluate the current evidence on combination therapy and address the occurrence of serious side effects, an aspect that is often overlooked owing to the severity of the infection; and (3) emphasize the need for home antimicrobial treatment of patients with IE, as these are fragile people who benefit from an early return to their environment. This poses undoubted logistical challenges and requires robust evidence to ensure the best short- and long-term outcomes.
Remodeling the tumor microenvironment to overcome treatment resistance in HPV-negative head and neck cancer
Authors: Benavente Sergi
Published: May 2023

Despite intensive efforts and refined techniques, overall survival in HPV-negative head and neck cancer remains poor. Robust immune priming is required to elicit a strong and durable antitumor immune response in immunologically cold and excluded tumors like HPV-negative head and neck cancer. This review highlights how the tumor microenvironment could be affected by different immune and stromal cell types, weighs the need to integrate metabolic regulation of the tumor microenvironment into cancer treatment strategies and summarizes the emerging clinical applicability of personalized immunotherapeutic strategies in HPV-negative head and neck cancer.
Influence of experience and professional skepticism on audit judgement of government external auditors
Authors: Sumartono Sumartono , Yana Ermawati  , Tania Meliana Rorong
Published: May 2023

The complexity of public services require auditors to perform audit judgments to ensure the quality of information and to evaluate the evidence presented in financial statements. Thus, the auditors’ judgment and technical skills are important factors in audit quality. This study examines how auditor independence, task complexity, auditor experience, and professional skepticism affect auditor judgment. Purposive sampling was employed to select auditors who worked at the Supreme Audit Institution (BPK-RI) of Papua Province. The data were collected using a set of a questionnaire consisting of 30 items measured on a Likert scale, distributed directly and via Google Forms. The data analyzes using multiple linear regression. The result presents empirical evidence that auditor experience and professional skepticism partially affected audit judgment, whereas task complexity and auditor independence did not have a partial effect on audit judgment. The study provides relevant and adequate insights to government external auditors regarding the factors that should be taken into consideration in maintaining and improving their audit judgments to bring optimal benefits for the local government stakeholders.
Editorial - Who needs ocean and polar diplomacy?
Authors: Meridiano 47 Editoria , Barros-Platiau Ana Flávia , Costa de Oliveira Carina , Gonçalves Leandra Regina
Published: May 2023

Esta edição especial "Who needs ocean and polar diplomacy?" busca estimular discussões sobre a relevância crescente da diplomacia oceânica e polar, particularmente no contexto da Década da Ciência Oceânica para o Desenvolvimento Sustentável (2021-2030) da ONU. Ela salienta o potencial do Brasil para contribuir com estes tópicos, além de ressaltar marcos significativos em 2023, como a negociação do tratado BBNJ na ONU e o lançamento do Plano Decenal para a Ciência Antártica do Brasil. A edição examina questões variadas, desde a governança dos oceanos e mudanças no Ártico até o papel do Brasil no cenário geopolítico da Antártica. Com base em pesquisas interdisciplinares, o conteúdo examina diferentes aspectos da governança oceânica e polar e pode oferecer insights valiosos para futuras pesquisas.
Vanadium Complexes with Thioanilide Derivatives of Amino Acids: Inhibition of Human Phosphatases and Specificity in Various Cell Models of Metabolic Disturbances
Authors: Kazek Grzegorz , Głuch-Lutwin Monika , Mordyl Barbara , Kubacka Monika , Jurowska Anna , Cież Dariusz , Trzewik Bartosz , Szklarzewicz Janusz , Papież Monika A.
Published: May 2023

In the text, the synthesis and characteristics of the novel ONS-type vanadium(V) complexes with thioanilide derivatives of amino acids are described. They have shown inhibition of human protein tyrosine phosphatases (PTP1B, LAR, SHP1 and SHP2) in the submicromolar range, as well as inhibition of non-tyrosine phosphatases (CDC25A and PPA2) similar to bis(maltolato)oxovanadium(IV)(BMOV). The ONS complexes increased [14C]-deoxy-D-glucose transport into C2C12 myocytes, and one of them, VC070, also enhanced this transport in 3T3-L1 adipocytes. These complexes inhibited gluconeogenesis in hepatocytes HepG2, but none of them decreased lipid accumulation in the non-alcoholic fatty liver disease model using the same cells. Compared to the tested ONO-type vanadium complexes with 5-bromosalicylaldehyde and substituted benzhydrazides as Schiff base ligand components, the ONS complexes revealed stronger inhibition of protein tyrosine phosphatases, but the ONO complexes showed greater activity in the cell models in general. Moreover, the majority of the active complexes from both groups showed better effects than VOSO4 and BMOV. Complexes from both groups activated AKT and ERK signaling pathways in hepatocytes to a comparable extent. One of the ONO complexes, VC068, showed activity in all of the above models, also including glucose utilization in the myocytes and glucose transport in insulin-resistant hepatocytes. The discussion section explicates the results within the wider scope of the knowledge about vanadium complexes.
A Compact Planar Wi-Fi Antenna with Optimized Radiation Patterns for Small UAV Applications
Authors: Yang Ya-Lung , Lin Ding-Bing
Published: May 2023

This paper proposes a compact planar Wi-Fi antenna with optimized radiation patterns for small unmanned aerial vehicle (UAV) applications in both urban and open areas. It is suitable for being mounted on the outermost side of the non-metallic wing of the small UAV. It has small dimensions of 16.5 mm (L) by 30.3 mm (W) by 1.6 mm (h), and the measured results of its prototype are in agreement with simulated data. Its impedance bandwidths over the two frequency ranges are 2.11 to 2.58 GHz and 5.06 to 7.5 GHz (S11≤-10 dB). At 5.8 GHz, it has stronger radiation below the small UAV to reduce interference from rare-use directions. Its maximum radiations, the directions of the maximum radiation in each elevation plane, are below the UAV and between 14 and 29 degrees from the horizontal plane. At 2.4 GHz, it has quasi-omnidirectional radiation to ensure a stable link in all directions, and its maximum radiations are near the horizontal plane. The optimized radiation patterns at 5.8 and 2.4 GHz can provide more antenna gain when the small UAV flies farther in urban and open areas, respectively. In addition, it has good vertically polarized radiation for long-distance applications.
Evaluation of Heavy Metal Removal in Forward Osmosis Process Using Functionalized HNTs-Based TFN NF Membranes
Authors: Atashgar Amirsajad , Emadzadeh Daryoush , Kruczek Boguslaw
Published: May 2023

Novel TFN membranes were examined for the removal of heavy metals (Cu and Pb) from synthetic wastewater in forward osmosis (FO) experiments using MgCl2 as a draw solute. The TFN membranes were fabricated on top of a commercial PS35 ultrafiltration membrane by in-situ interfacial polymerization of piperazine (PIP) and 1,3,5-benzenetricarbonyl trichloride (TMC) containing different amounts of dispersed functionalized halloysite nanotubes (HNTs) nanoparticles. The HNTs nanoparticles were functionalized with the first generation of poly(amidoamine) (PAMAM) dendrimers. The TFN and the control TFC membranes showed rejections of Cu2+ and Pb2+, ranging from 94.5% to 98.1%. The presence of heavy metal in the feed solution enhanced the FO performance of all membranes. In particular, the reverse flux of MgCl2 decreased at least 2.5 times compared to the experiments with pure water as a feed. Simultaneously, the water flux also increased. The improved FO performance of the membranes in the presence of heavy metal ions is attributed to their adsorption by the membranes. The adsorption of heavy metals was confirmed by a decrease in the negativity of zeta potential and the results from inductively coupled plasma mass spectrometry (ICP-MS) of the membranes after the FO experiments.
Sequence of Rare Diagnoses in a Young Patient: Altitude Barotrauma Hemopneumothorax and Desquamative Interstitial Pneumonia
Authors: Leonte Iustina , Ivanov Karina , Marghescu Angela Stefania , Matache Șerban-Radu , Negru Florica Valeria , Iorga Ana Luiza , Dumitru Silviu Mihail , Mahler Beatrice
Published: May 2023

We present the case of a 35-year-old patient without pathological history who developed hemopneumothorax due to altitude barotrauma during a commercial airline flight. The computed tomography of the chest identified the presence of emphysema "blebs" and bubbles, and the histopathological examination of the lung fragment obtained during the diagnostic and therapeutic thoracoscopy identified elements suggestive for the diagnosis of respiratory bronchiolitis associated with desquamative interstitial pneumonia (DIP).
Neuroprotective Potential of L-glutamate Transporters in Human Induced Pluripotent Stem Cell-Derived Neural Cells against Excitotoxicity
Authors: Takahashi Kanako , Ishibashi Yuto , Chujo Kaori , Suzuki Ikurou , Sato Kaoru
Published: May 2023

Human induced pluripotent stem cell (hiPSC)-derived neural cells have been used at the preclinical stage of drug development. As previously reported, hiPSC-derived neurons exhibit greater tolerance to excitotoxicity than that of primary cultures of rodent neurons; however, the underlying mechanisms remain unknown. We therefore investigated the functions of L-glutamate (L-Glu) transporters, the most important machinery used to maintain low extracellular L-Glu concentrations, in hiPSC-derived neural cells. We also clarified the contribution of each L-Glu transporter subtype. At 63 days in vitro (DIV), we detected neuronal circuit functions in hiPSC-derived neural cells by a microelectrode array system (MEA). Exposure to 100 μM L-Glu for 24 hrs did not affect the viability of these 63 DIV neural cells. Pharmacological inhibition of excitatory amino acid transporter 1 (EAAT1) and EAAT2 blocked almost 100% of L-Glu uptake. In this condition, L-Glu exposure dramatically decreased cell viability. These results suggest that in hiPSC-derived neural cells, EAAT1 and EAAT2 are predominant L-Glu transporters, and their uptake potentials are stronger than those of primary cultures of rodent neurons. Furthermore, hiPSC-derived neural cells may be useful for screening drugs that target L-Glu transporters.
The COVID-19 Impact on Accidental Deaths and Suicide Incidence in India- A Comparative Study (1967-2022)
Authors: Kumar Piyush , Anupama Advocate
Published: May 2023

Globally 703 000 people commit suicide (4th leading cause of mortality among 15-29 year-olds, 1.4% of all deaths globally) every year, which have a negative effect on families, colleagues, and societies. India accounts for 36.6 percent of global suicide in women and 24.3 percent among men, while having only 17.8 percent of the global population, also remarkable fact is that the suicide ratio for female is 14.7 per 100,000 compared to 21.2 per 100,000 of male which is 2.1 times the global average in female, while 1.4 times higher for men. COVID-19 (coronavirus disease-2019) pandemic has certainly affected the physical, mental, economical and social well being of global population directly or indirectly in different ways. Deteriorating physical, mental, economical and social health of an individual could increase the suicidal tendency, leading to accidents and suicide. This study tried to find out the COVID-19 pandemic situation impact on accidental death as well as suicide rates in India. The study period is from 1st January 1967 to 31st December 2021, to assess the effect of the COVID-19 pandemic situation on suicide and accidental death rates. This study revealed that the suicide deaths percentage among males increased significantly in comparison to females in COVID-19 era and actual count and incidence also increased. This study revealed that the mean accidental death and suicide both increased during COVID period of study as compared to pre-pandemic whole period from 1967 by 25.47 % and 30.61% respectively. Alternatively we can say that the accidental death and suicides increased significantly in India, which is largely preventable.