bluuebunny/crossref_metadata_2025 huggingface dataset:
Fluorination Homologation of Biorenewable Synthon Cyrene
Authors: Puschnig Johannes , Greatrex Ben W.
Published: December 2024

A one-carbon difluorocyclopropanation/ring-expansion has been developed for the chiral synthon Cyrene, which is obtained via cellulose pyrolysis. The ring-enlargement was achieved by converting Cyrene (dihydrolevoglucosenone) into an enamine, reacting it with an in situ-generated difluorocarbene, and then heating it to ring-open the cyclopropane. Access to the product provides access to fluorinated analogues of this valuable chiral biomass derivative.
A Protic Ionic Liquid Promoted Gel Polymer Electrolyte for Solid-State Electrochemical Energy Storage
Authors: Liu Jiaxing , Wang Zan , Yang Zhihao , Liu Meiling , Liu Hongtao
Published: December 2024

This study presents the synthesis of a transparent, flexible gel polymer electrolyte (GPE) based on the protic ionic liquid BMImHSO4 and on polyvinyl alcohol (PVA) through solution casting and electrochemical evaluation in a 2.5 V symmetrical C/C electrical double-layer solid-state capacitor (EDLC). The freestanding GPE film exhibits high thermal stability (>300 °C), wide electrochemical windows (>2.7 V), and good ionic conductivity (2.43 × 10−2 S cm−1 at 20 °C). EDLC, using this novel GPE film, shows high specific capacitance (81 F g−1) as well as good retention above 90% of the initial capacitance after 4500 cycles. The engineered protic ionic liquid GPE is, hopefully, applicable to high-performance solid-state electrochemical energy storage.
The Influence of CLSM Magnification on the Measured Roughness of Differently Prepared Dental Materials
Authors: Rosentritt Martin , Schmutzler Anne , Hahnel Sebastian , Kurzendorfer-Brose Laura
Published: December 2024

This in vitro study investigated how varying magnifications (5×, 10×, 20×, and 50×) using a confocal laser scanning microscope (CLSM) influence the measured surface roughness parameters, Ra/Sa and Rz/Sz, of various materials with two surface treatments. Cylindrical specimens (d ≈ 8 mm, h ≈ 3 mm, n = 10) from titanium, zirconia, glass-ceramic, denture base material, and composite underwent diamond treatment (80 μm; wet) and polishing (#4000; wet; Tegramin-25, Struers, G). The surface roughness parameters (Ra/Sa, Rz/Sz) were measured with a CLSM (VK-100, Keyence, J) at 5×, 10×, 20×, and 50× magnifications. Line roughness (Ra/Rz) was measured along a 1000 μm distance in three parallel lines, while area roughness (Sa/Sz) was evaluated over a 2500 μm × 1900 μm area. The statistical analysis included ANOVA, the Bonferroni post hoc test, and Pearson correlation (SPSS 29, IBM, USA; α = 0.05). Ra/Sa and Rz/Sz showed significant differences (p ≤ 0.001, ANOVA) across magnifications, with values decreasing as magnification increased, highest at 5× and lowest at 50×. Titanium, zirconia, and glass-ceramic showed significant measured roughness values from 5× to 50×. Denture base material and composite had lower measured roughness values, especially after polishing. Line and area roughness varied significantly, indicating that magnification affects measured values. Standardizing magnifications is essential to ensure comparability between studies. A 50× magnification captures more detailed profile information while masking larger defects.
Reinforcing Bus Living Space with Recycled Carbon Fibers from Expired Prepreg in the Aircraft Industry
Authors: Martínez Miguel Angel , Lavayen-Farfán Daniel , Abenojar Juana , López-Boada María Jesús , García-Pozuelo Daniel
Published: December 2024

Due to increasing mobility and energy conservation needs, improving bus and coach safety without adding weight is essential. Many crashes with fatal outcomes for vehicle occupants are associated with the rollover of the vehicle, revealing the structural weakness of the steel pillars between windows, which must resist high levels of bending during rollovers. This study aims to reinforce these pillars with expired carbon fiber prepreg from the aircraft industry, improving safety and reducing environmental waste. To manufacture the pillars, shot-blasted hollow S275 steel tubes with a side length of 25 mm and a thickness of 1.5 mm were used. Bidirectional GG600T woven carbon fiber, CF, and aircraft-grade recycled carbon fiber-reinforced plastic, rCFRP, prepreg M21EV/IMA/3 were used as composite reinforcements. The first composite was made from a CF weave using the rigid epoxy resin Sicomin® 8500/Sicomin® SD8601. The rCFRP composite was frayed, and a new composite was made with the same rigid epoxy resin. Both composites were joined to the steel tube using a tough structural adhesive (SikaPower® 1277). A third composite was obtained using the frayed rCFRP and the structural adhesive as a polymer matrix. All composites were treated with an APPT (atmospheric-pressure plasma torch) before being joined to the steel pillar with the structural adhesive. The comparison of the three reinforcements showed that the steel reinforced with the recycled prepreg composite manufactured with the rigid adhesive performed best, with a 50% increase in specific bending strength and only a 32% increase in weight. It also absorbed 71% more energy, which shows that this novel option for upcycling can noticeably increase the crashworthiness of structures.
Low-Cost Open-Source Melt Flow Index System for Distributed Recycling and Additive Manufacturing
Authors: Liu Dawei , Basdeo Aditi , Gonzalez Catalina Suescun , Romani Alessia , Boudaoud Hakim , Nouvel Cécile , Cruz Sanchez Fabio A. , Pearce Joshua M.
Published: December 2024

The increasing adoption of distributed recycling via additive manufacturing (DRAM) has facilitated the revalorization of materials derived from waste streams for additive manufacturing. Recycled materials frequently contain impurities and mixed polymers, which can degrade their properties over multiple cycles. This degradation, particularly in rheological properties, limits their applicability in 3D printing. Consequently, there is a critical need for a tool that enables the rapid assessment of the flowability of these recycled materials. This study presents the design, development, and manufacturing of an open-source melt flow index (MFI) apparatus. The open-source MFI was validated with tests on virgin polylactic acid pellets, shredded recycled poly(ethylene) terephthalate glycol flakes, and high-density polyethylene/poly(ethylene) terephthalate blends to demonstrate the range of polymer types and recyclability. The proposed MFI tool offers a user-friendly and cost-effective solution for evaluating the flow properties of materials from waste streams, thereby enhancing their viability for additive manufacturing applications.
Phase Evolution in Mn1.6Zn0.2Ni0.6Mg0.2Al0.4O4 High-Entropy Oxide Films by Heat Treatment
Authors: Ren Wei , Liu Xianhai , Wu Wenting , Wang Weili
Published: December 2024

In this work, Mn-Zn-Ni-Mg-Al multi-layer films were annealed in air at different temperatures to form spinel-structured Mn1.6Zn0.2Ni0.6Mg0.2Al0.4O4 high-entropy oxide films. X-ray diffraction results demonstrate that the films possess a polycrystalline spinel phase as well as impurity phases: when annealed at 650 °C and 750 °C, MnO2 and Al2O3 impurity phases exist; at 950 °C, an Al2O3 impurity phase exists. Only at 850 °C does a pure spinel phase exist. However, the film at 750 °C exhibits the best conductive behavior, which indicates that the impurity phases may not have to be removed to maintain the best electrical properties of the film.
Hybrid Microwave/Solar Energy Harvesting System Using 3D-Printed Metasurfaces
Authors: Drymiskianaki Argyri , Viskadourakis Zacharias , Kenanakis George
Published: December 2024

In this study, a hybrid energy harvesting system based on a conventional solar cell combined with 3D-printed metasurface units is studied. Millimeter-scale metasurface units were fabricated via the stereolithography technique, and then they were covered with conductive silver paint, in order to achieve high electric conductivity. The performance of single, as well as two-unit metasurface harvesters, was thoroughly investigated. It was found that both of them produced voltage, which peaks at their resonance frequency, demonstrating efficient energy harvesting behavior in the microwave regime. Then, the metasurface units were connected with a commercially available photovoltaic panel and the performance of the hybrid system was examined under different environmental conditions, modifying the light intensity (i.e., light, dark and shadow). It was shown that the proposed hybrid harvesting system produces a sizable voltage output, which persists, even in the case when one of the components does not contribute. Furthermore, the performance of the hybrid harvester is found to be adequate enough, although optimization of the harvesting circuit is required in order to achieve high efficiency levels. All in all, the presented experimental evidence clearly indicates the realization of a rather promising hybrid energy harvesting system, exploiting two distinct ambient energy sources, namely light and microwaves.
Synthesis and Electron-Transporting Properties of N-Type Polymers with Cardanol-Based Side Chains
Authors: Cheng Jin , Fu Hongyu , Qiao Yifan , Xue Xuming , Sudprasert Pirada , Ogino Kenji
Published: December 2024

We synthesized n-type polymers poly{[N,N′-bis(2-octyldodecyl)-naphthalene-1,4,5,8-bis(dicarboximide)-2,6-diyl]-alt-5,5′-(2,2′-bithiophene)} [P(NDI2OD-T2)] and poly{[N,N′-bis(3-(4-cardanol)propyl)-naphthalene-1,4,5,8-tetracarboxylic diimide]-alt-[5,5′-bis(2-thienyl)-2,2′-bithiophene]} [P(NDICL-T2)] with cardanol-based side chains via Stille coupling to enhance electron mobility. Replacing the 2-octyldodecyl side chain with cardanol in P(NDICL-T2) improved electron mobility due to increased chain flexibility and ordered packing. Lower glass transition temperature (tg), red-shifted UV-vis absorption, results from crystalline structure analysis, indicating tighter lamellar spacing and enhanced molecular ordering, and smoother surface morphology confirmed the enhanced intermolecular interactions and uniform film formation.
Pipeline Transport Performance of Paste Backfill Slurry in Long-Distance Underground Backfilling: A Review
Authors: Wang Wei , Yu Bin , Xu Wenyuan , Yang Kai , Yin Yanying , Li Mengyuan
Published: December 2024

This paper reviews recent advancements in the pipeline transport performance of paste backfill slurry in long-distance underground backfilling operations, with a primary focus on applications in metal mines. Key aspects, including flow performance, energy consumption during transport, and operational stability, are discussed in detail. Slurry concentration and rheological properties, including viscosity, yield stress, and flow behavior, as well as particle size distribution, are examined for their effects on transport efficiency. The relationship between these characteristics and pipeline resistance is also examined. Factors like pipeline orientation, configuration, diameter, length, elbow design, and elevation gradients are explored, demonstrating that careful design can optimize flow performance, reduce energy consumption, and minimize the risk of blockages and bursts. Additionally, the roles of commonly used additives, such as water reducers, foaming agents, antifreeze agents, and thickeners, are discussed in terms of their impact on slurry flowability, stability, and resistance losses. Optimal slurry regulation, strategic pipeline design, and effective additive utilization improve flow efficiency, extend service life, and reduce maintenance costs, thereby ensuring reliable backfill operations. Future research should focus on innovative pipeline designs, such as improving material selection and configuration to optimize flow stability and reduce energy consumption. Advanced additives, including thickeners and water reducers, could further enhance slurry flowability, reduce pipeline resistance, and improve system reliability.
Correction: Yaseen et al. Photo-Assisted Removal of Rhodamine B and Nile Blue Dyes from Water Using CuO–SiO2 Composite. Molecules 2022, 27, 5343
Authors: Yaseen Muhammad , Humayun Muhammad , Khan Abbas , Idrees Muhammad , Shah Nasrullah , Bibi Shaista
Published: December 2024

Citation of the publication (our own previous work), Yaseen, M [...]
Research on the Structure and Properties of Traditional Handmade Bamboo Paper During the Aging Process
Authors: Zhu Zirui , Zhang Kai , Xue Yu , Liu Zhongming , Wang Yujie , Zhang Yanli , Liu Peng , Ji Xingxiang
Published: December 2024

Handmade papers, as carriers of paper-based cultural relics, have played a crucial role in the development of human culture, knowledge, and civilization. Understanding the intricate relationship between the structural properties and degradation mechanisms of handmade papers is essential for the conservation of historical documents. In this work, an artificial dry-heat-accelerated aging method was used to investigate the interplay among the mechanical properties of paper, the degree of polymerization (DP) of cellulose, the chemical composition, the hydrogen bond strength, the crystallinity, and the degree of hornification for paper fibers. The results demonstrated for the first time that the mechanical properties of handmade bamboo paper exhibited an initial plateau region, a rapid decline region, and sometimes a second plateau region as it undergoes a dry-heat aging process. The changes in cellulose, hemicellulose, and lignin content were tracked throughout these three stages. The lignin content was relatively stable, while the cellulose and hemicellulose content decreased, which was consistent with the observed decline in mechanical properties. When the DP of cellulose decreased to the range of 600–400, there was a critical point in the mechanical properties of the paper, marking a transition from the initial stable region to a rapid decline region. The fiber embrittlement caused by cellulose chain breakage resulting from the decrease in DP was counteracted by the enhancement of intermolecular hydrogen bonds and the hornification process. A second stable region appeared when the DP was less than 400, marking a transition from a balanced or slightly decreasing trend in the initial plateau region to a sharp decline. This study also discussed for the first time that the formation of the second plateau region may be due to the presence of hemicellulose and lignin, which hinder the further aggregation of cellulose and maintain the structural stability of the fiber cell. The findings of this study can provide guidance for improving ancient book preservation strategies. On the one hand, understanding how these components affect the durability of paper can help us better predict and slow down the aging of ancient books. On the other hand, specific chemical treatment methods can be designed to stabilize these components and reduce their degradation rate under adverse environmental conditions.
Bithiophene-Based Donor–π–Acceptor Compounds Exhibiting Aggregation-Induced Emission as Agents to Detect Hidden Fingerprints and Electrochromic Materials
Authors: Filipek Patrycja , Kałkus Magdalena , Szlapa-Kula Agata , Filapek Michał
Published: December 2024

A group of bithiophenyl compounds comprising the cyanoacrylate moiety were designed and successfully synthesized. The optical, (spectro)electrochemical, and aggregation-induced emission properties were studied. DFT calculations were used to explain the reaction’s regioselectivity and to determine the molecules’ energy parameters (i.e., band gaps, HOMO levels, and LUMO levels). The aggregation-induced emission of compounds has been studied in the mixture of DMF (as a good solvent) and water (as a poor solvent), with different water fractions ranging from 0% to 99%. It has been shown that there are differences in the physicochemical properties of the obtained compounds due to the length of the alkyl chain in the ester group. Investigated derivatives were tested for their potential use in visualizing latent fingerprints and electrochromic materials.
Phytochemical Profile and Biological Activity of the Ethanol Extracts from the Aerial Parts of Adonis tianschanica (Adolf.) Lipsch. Growing in Kazakhstan
Authors: Orynbekova Saule , Kukula-Koch Wirginia , Sakipova Zuriyadda , Alsharif Bashaer , Rafferty Beibhinn , Nurgozhin Talgat , Allambergenova Zoya , Dreher Piotr , Głowniak Kazimierz , Boylan Fabio
Published: December 2024

Adonis tianschanica is a lesser-known plant species belonging to the genus Adonis that grows in Kazakhstan. The aim of this study was to characterize the composition of the ethanolic, water, and hydroethanolic extracts from the aerial parts of A. tianschanica by HPLC-ESI-QTOF-MS/MS to isolate the major compound isoquercitrin by HSCCC (High-Speed Counter-Current Chromatography) and to determine the cytotoxicity and anti-inflammatory potential of the extracts produced with this plant. Fingerprinting of the analyzed extracts showed the presence of a multitude of metabolites comprising polyphenols, organic acids, and coumarins, and only trace quantities of cardiac glycosides in the analyzed samples. Flavonoids were certainly the best-represented group, with kaempferol, quercetin, and their derivatives as the major components of the extracts. Key findings in this paper were that the ethanol: water (50:50 v/v) extract of A. tianschanica and its major compound isoquercitrin were able to reduce the production of NO induced by LPS, in addition to demonstrating anti-inflammatory effects by reducing cytokines such as IL-6, TNF-α, and IL-1β.
Synthesis, Characterization and Catalytic/Antimicrobial Activities of Some Transition Metal Complexes Derived from 2-Floro-N-((2-Hydroxyphenyl)Methylene)Benzohydrazide
Authors: Hijazi Ahmed K. , Taha Ziyad A. , Issa Dua’a K. , Alshare Heba M. , Al-Momani Waleed M. , Elrashidi Ali , Barham Ahmad S.
Published: December 2024

Background: In the last few decades, the field of coordination chemistry has grown very fast, especially in the fields of pharmaceutical, biological and catalytic studies. In ancient times, metals were thought to be beneficial to health issues but nowadays the link between organic–metal substances and different industrial and medicinal properties is well established. Methods: A Schiff base ligand (2-fluoro-N’-[(E)-2-hydroxyphenyl) methylene] benzohydrazide) was reacted with a series of transition metals to produce complexes with a general formula [ML2(NO3)]NO3.nH2O, where [M = Zn, Cu, Co, Ni, Mn], and [n = 0, 1], corresponding to complexes 1–5. The nature of the bond was determined in the solid state and solution using spectral studies (1H-NMR, 13C-NMR, UV-Vis and FT-IR), TGA, EPR, elemental analysis and molar conductivity measurement. Results: All M(II) complexes are 1:1 electrolytes, as illustrated by their molar conductivities. The results demonstrate that all synthesized complexes present a coordination number of six by the bonding of the bidentate ligand via its azomethine nitrogen atoms and carbonyl oxygen atoms, as well as with one nitrate group as a bidentate ligand via two oxygen atoms. The DPPH radical scavenging technique was used to investigate the antioxidant activities of the ligand [L] and the metal complexes. It is clear that the activity increased in M (II) complexes compared to the Schiff base ligand. Complex 5 showed the highest activity, with an excellent activity of 90.4%, while complex 4 showed the lowest. The antibacterial activities of the Schiff base and its complexes have been examined against various pathogenic bacteria to measure their inhibition potential. Complex 2 showed remarkable activity against Gram (+) bacteria and fungi with an MIC value of 8 μg/mL, which is greater than that of the positive controls, oxytetracycline and fluconazole. The catalytic activities of all complexes were examined in the oxidation of aniline, and the results illustrated that all complexes had a 100% selectivity in producing only azobenzene, and complex 4 had the highest activity (91%). Conclusion: The obtained results from this study show that the antioxidant and antibacterial properties of both the Schiff base ligand and its derived complexes are promising, with some demonstrating remarkable activities. Moreover, the catalytic activities and selectivities of the prepared complexes in aniline oxidation are interesting.
Flavonoids and Other Polyphenols: Bioactive Molecules from Traditional Medicine Recipes/Medicinal Plants and Their Potential for Phytopharmaceutical and Medical Application
Authors: Intharuksa Aekkhaluck , Kuljarusnont Sompop , Sasaki Yohei , Tungmunnithum Duangjai
Published: December 2024

Currently, natural bioactive ingredients and/or raw materials are of significant interest to scientists around the world. Flavonoids and other polyphenols are a major group of phytochemicals that have been researched and noted as bioactive molecules. They offer several pharmacological and medical benefits. This current review aims to (1) illustrate their benefits for human health, such as antioxidant, anti-aging, anti-cancer, anti-inflammatory, anti-microbial, cardioprotective, neuroprotective, and UV-protective effects, and also (2) to perform a quality evaluation of traditional medicines for future application. Consequently, keywords were searched on Scopus, Google Scholar, and PubMed so as to search for related publications. Then, those publications were carefully checked in order to find current and non-redundant studies that matched the objective of this review. According to this review, researchers worldwide are very interested in discovering the potential of flavonoids and other polyphenols, used in traditional medicines and taken from medicinal plants, in relation to medical and pharmaceutical applications. Many studies focus on the health benefits of flavonoids and other polyphenols have been tested using in silico, in vitro, and in vivo models. However, few studies have been carried out using clinical trials that have trustworthy subject sizes and are in accordance with clinical practice guidelines. Additionally, interesting research directions and perspectives for future studies are highlighted in this work.
Structure and Electrocatalytic Properties of Sulfur-Containing Multi-Walled Carbon Nanotubes on a Titanium Substrate Modified by a Helium Ion Beam
Authors: Korusenko Petr M. , Knyazev Egor V. , Vinogradov Alexander S. , Kharisova Ksenia A. , Filippova Sofya S. , Rodionova Ulyana M. , Levin Oleg V. , Alekseeva Elena V.
Published: December 2024

In this work, a set of analytical techniques, including scanning electron microscopy (SEM), Raman scattering spectroscopy, X-ray photoelectron spectroscopy (XPS), energy-dispersive X-ray microanalysis (EDX) and cyclic voltammetry (CV), were used to study the impact of high-energy He+ ion irradiation on the structural and electrochemical characteristics of sulfur-containing multi-walled carbon nanotubes (S-MWCNTs) placed on a titanium substrate. The results indicate that the ion beam treatment of the S-MWCNT system led to an increase in the level of imperfections on the surface structures of the nanotubes due to the formation of point defects on their outer walls and the appearance of oxygen-containing functional groups, including SOx groups, near these defects. At the same time, a significant increase in the sulfur concentration (by 6.4 times) was observed on the surface of the S-MWCNTs compared to the surface of unirradiated nanotubes. This was due to the redeposition of sulfur atoms near the point defects under the action of the ion beam, followed by the subsequent formation of direct S–C chemical bonds. Electrochemical studies demonstrated that the irradiated S-MWCNTs/Ti system exhibit enhanced catalytic activity, with improved oxygen reduction reaction (ORR) performance and a substantial increase in anodic current during the oxidation reaction of hydrogen peroxide under alkaline conditions, highlighting their potential for advanced electrocatalytic applications.
Impact of Plant Species on the Synthesis and Characterization of Biogenic Silver Nanoparticles: A Comparative Study of Brassica oleracea, Corylus avellana, and Camellia sinensis
Authors: Demirel Bayik Gülçin , Baykal Busenur
Published: December 2024

The choice of plant species is crucial, as different plants provide unique biomolecules that influence nanoparticle characteristics. Biomolecules in plant extracts, such as proteins, amino acids, enzymes, polysaccharides, alkaloids, tannins, phenolics, saponins, terpenoids, and vitamins, act as stabilizing and reducing agents. This study explores the synthesis of silver nanoparticles (AgNPs) using leaf extracts from collard greens (Brassica oleracea var. acephala), hazelnut (Corylus avellana var. avellana), and green tea (Camellia sinensis). NPs were synthesized using silver nitrate (AgNO3) solution at two different molarities (1 mM and 5 mM) and characterized by UV–Vis spectroscopy, XRD, TEM, and FTIR. The Surface Plasmon Resonance (SPR) peaks appeared rapidly for hazelnut and green tea extracts, within 30 and 15 min, respectively, while collard greens extract failed to produce a distinct SPR peak. X-Ray Diffraction confirmed the formation of face-centered cubic silver. TEM analysis revealed high polydispersity and agglomeration in all samples, with particle size generally decreasing at higher AgNO3 concentrations. However, hazelnut extract showed a slight increase in size at higher molarity. Among all samples, green tea-derived AgNPs synthesized with 5 mM AgNO3 were the smallest and least polydisperse, highlighting the significant role of plant type in optimizing nanoparticle synthesis.
Influence of Biological Sex and Congenital Iron Deficiency on Neonatal Cytokine Responses
Authors: Mukhtarova Narmin , Babu Anthony , Coe Christopher L. , Kling Pamela J.
Published: December 2024

Background/Objectives: Stimulated cord blood mononuclear cell (CBMC) cytokine responses were previously shown to predict the risk of childhood atopic disease. Iron deficiency (ID) at birth may also program atopic disease. Males are at a higher risk of pediatric atopic disease, but it is not known whether congenital ID impacts CBMC immune responses differentially by sex. Methods: Cord blood (CB) samples were collected from healthy term or near-term neonates after elective cesarean deliveries. A transferrin saturation ≤ 25% defined congenital ID. CBMCs were stimulated with either phytohemagglutinin (PHA) or PHA plus an iron chelator. Results: Of the 85 neonates, the 26 neonates with congenital ID exhibited lower plasma tumor necrosis factor-α (TNF-α), as well as higher CBMC TNF-α and IL-8 responses than iron-sufficient neonates (p = 0.017, p = 0.013, and p = 0.007, respectively). Higher CBMC TNF-α responses were seen in both males and females with congenital ID. However, females with congenital ID also had lower plasma IL-6, lower plasma TNF-α, and higher CBMC interleukin (IL)-8 responses. Additionally, iron chelation during culture influenced stimulated CBMC IFN-γ and CBMC TNF-α responses. Discussion: Congenital ID may influence stimulated CBMC cytokine responses, but results point to a sex-specific regulation of immune balance at birth. Because males are more prone to infantile ID and more likely to develop early childhood asthma, future studies should further investigate how fetal sex and congenital iron status impacts childhood immune responsiveness to infections and antigenic stimulation from the rearing environment.
Perception of Pediatric Nurses on the Use of Standardized Nursing Handover Process in Intra-Hospital Patients Transfer: Attitudes, Barriers, and Practical Challenges
Authors: Martínez-Muñoz Irene , Díaz-Agea José Luis , Pastor-Rodríguez Jesús David
Published: December 2024

Standardized transfer is an evidence-based framework designed to improve communication between healthcare professionals, reducing risks and ensuring safe, high-quality care. Despite its benefits, implementing this framework in clinical practice poses challenges. Nurses often do not use a systematic guide as a theoretical framework for handovers in daily practice. Objective: To explore nurses’ perceptions regarding the use of standardized transfers. Methodology: This exploratory qualitative cross-sectional study aimed to gain insight into nurses’ experiences and perspectives on pediatric patient transfers. Using purposive sampling, nurses from the pediatric intensive care unit and hospital wards at the hospital institution hosting the study were interviewed. Data were collected through 21 in-depth individual interviews conducted between April and May 2023. The semi-structured interviews, lasting 16 to 28 min, focused on nurses’ views on communication between units during patient transfers. The qualitative approach allowed for a comprehensive understanding of nurses’ perceptions, particularly the barriers they face in practice. The study included 21 nurses: 9 from the pediatric intensive care unit and 12 from pediatric wards. To ensure diverse representation, nurses with varying levels of work experience were included, and at least one nurse from each hospital ward participated. Results: The data were classified into the following main categories: the current state of pediatric patient transfers, attitudes of healthcare professionals, barriers and challenges to implementation, nursing documentation, motivational aspects, and the child-family relationship. The findings revealed significant issues in the communication process during patient transfers, with no systematic guidelines in place. While nurses demonstrated a positive attitude toward the standardization of transfers, they identified numerous practical challenges, particularly those related to the hospital’s nursing documentation system. Conclusions: Nurses view standardized transfers favorably, but they face substantial barriers that limit their practical implementation.
Enlightening Hidden Nursing Care in Nurse-Led Clinics and See & Treat: An Observational Multicenter Protocol Study in Italy
Authors: Zaghini Francesco , Caponnetto Valeria , Cesare Manuele , Di Nitto Marco , Marcomini Ilaria , Iovino Paolo , Longobucco Yari , Bagnasco Annamaria , Lancia Loreto , Manara Duilio Fiorenzo , Rasero Laura , Rocco Gennaro , Cicolini Giancarlo , Mazzoleni Beatrice , Zega Maurizio , Sermeus Walter , Drennan Jonathan , Welton John , Sasso Loredana , Alvaro Rosaria
Published: December 2024

Background/Objectives: The limited and inconsistent adoption and regulation of nurse-led clinics (NLCs) and “See & Treat” (S&T) services in Italy needs to be explored considering their value towards patients’ outcomes acknowledged in the literature. This study aims to explore the phenomenon of hidden nursing activities (HNAs) in these settings, hypothesizing that features and activities performed in these settings are heterogeneous across the country and widely underreported or attributed to other professionals than nurses. HNAs are hypothesized to be associated with a poor work environment climate and nurses’ low job satisfaction. Methods: A multicenter, cross-sectional study will be conducted across exclusively nurse-led NLC and S&T services in public health care facilities in Italy. Data collection will involve inputs from organization or nursing managers, coordinators, head nurses, and employed nurses. Information will be gathered on organizational structure, service provision, access modalities, nurses’ perceptions of their work environment, and the health care activities performed. Surveys will be distributed online to collect retrospective data in 2023 and via paper to collect 1-month prospective data about services’ activities. Expected results: This study is expected to reveal HNAs in NLC and S&T, with implications for policy, resource allocation, reimbursement models, and patient outcomes, ultimately supporting healthcare reforms and enhancing nursing’s visibility and impact in Italy. The findings will be essential for guiding health care resource allocation and shaping educational and regulatory policies that recognize and formalize the role of nurses in advanced practice. Policymakers could leverage the findings of this study to promote the development of standardized taxonomies, making nursing contributions more visible and measurable. Ultimately, this research will highlight the value of nursing care in NLC and S&T settings, providing an evidence base to drive policy changes that improve both health care outcomes and resource efficiency. Conclusions: This study lays the groundwork for health care policy reforms by advocating for the recognition, measurement, and funding of nursing contributions, ultimately enhancing patient outcomes and the sustainability of health systems.
Identification of a Potential PGK1 Inhibitor with the Suppression of Breast Cancer Cells Using Virtual Screening and Molecular Docking
Authors: Chen Xianghui , Zuo Zanwen , Li Xianbin , Li Qizhang , Zhang Lei
Published: December 2024

Background/Objectives: Breast cancer is the second most common malignancy worldwide and poses a significant threat to women’s health. However, the prognostic biomarkers and therapeutic targets of breast cancer are unclear. A prognostic model can help in identifying biomarkers and targets for breast cancer. In this study, a novel prognostic model was developed to optimize treatment, improve clinical prognosis, and screen potential phosphoglycerate kinase 1 (PGK1) inhibitors for breast cancer treatment. Methods: Using data from the Gene Expression Omnibus (GEO) database, differentially expressed genes (DEGs) were identified in normal individuals and breast cancer patients. The biological functions of the DEGs were examined using bioinformatics analysis. A novel prognostic model was then constructed using the DEGs through LASSO and multivariate Cox regression analyses. The relationship between the prognostic model, survival, and immunity was also evaluated. In addition, virtual screening was conducted based on the risk genes to identify novel small molecule inhibitors of PGK1 from Chemdiv and Targetmol libraries. The effects of the potential inhibitors were confirmed through cell experiments. Results: A total of 230 up- and 325 down-regulated DEGs were identified in HER2, LumA, LumB, and TN breast cancer subtypes. A new prognostic model was constructed using ten risk genes. The analysis from The Cancer Genome Atlas (TCGA) indicated that the prognosis was poorer in the high-risk group compared to the low-risk group. The accuracy of the model was confirmed using the ROC curve. Furthermore, functional enrichment analyses indicated that the DEGs between low- and high-risk groups were linked to the immune response. The risk score was also correlated with tumor immune infiltrates. Moreover, four compounds with the highest score and the lowest affinity energy were identified. Notably, D231-0058 showed better inhibitory activity against breast cancer cells. Conclusions: Ten genes (ACSS2, C2CD2, CXCL9, KRT15, MRPL13, NR3C2, PGK1, PIGR, RBP4, and SORBS1) were identified as prognostic signatures for breast cancer. Additionally, results showed that D231-0058 (2-((((4-(2-methyl-1H-indol-3-yl)-1,3-thiazol-2-yl)carbamoyl)methyl)sulfanyl)acetic acid) may be a novel candidate for treating breast cancer.
Tissue Engineering Construct for Articular Cartilage Restoration with Stromal Cells from Synovium vs. Dental Pulp—A Pre-Clinical Study
Authors: Fernandes Tiago Lazzaretti , Santanna João Paulo Cortez , de Faria Rafaella Rogatto , Pastore Enzo Radaic , Bueno Daniela Franco , Hernandez Arnaldo José
Published: December 2024

Background/Objectives: Cartilage injuries and osteoarthritis are prevalent public health problems, due to their disabling nature and economic impact. Mesenchymal stromal cells (MSCs) isolated from different tissues have the immunomodulatory capacity to regulate local joint environment. This translational study aims to compare cartilage restoration from MSCs from the synovial membrane (SM) and dental pulp (DP) by a tissue-engineered construct with Good Manufacturing Practices. Methods: A controlled experimental study was conducted on fourteen miniature pigs, using scaffold-free Tissue Engineering Constructs (TECs) from DP and SM MSCs, with a 6-month follow-up. Total thickness cartilage defects were created in both hind knees; one side was left untreated and the other received a TEC from either DP (n = 7) or SM (n = 7). An MRI assessed the morphology using the MOCART scoring system, T2 mapping evaluated water, and collagen fiber composition, and histological analysis was performed using the ICRS-2 score. Results: The untreated group had a mean MOCART value of 46.2 ± 13.4, while the SM-treated group was 65.7 ± 15.5 (p < 0.05) and the DP-treated group was 59.0 ± 7.9 (n.s.). The T2 mapping indicated a mean value of T2 of 54.9 ± 1.9 for native cartilage, with the untreated group at 50.9 ± 2.4 (p < 0.05). No difference was found between the T2 value of native cartilage and the treated groups. The ICRS-2 mean values were 42.1 ± 14.8 for the untreated group, 64.3 ± 19.0 for SM (p < 0.05), and 54.3 ± 12.2 for DP (n.s.). Conclusion: MRI and histological analysis indicated that TEC treatment led to superior cartilage coverage and quality compared to the defect group. TECs from SM demonstrated better results than the defect group in the histological assessment.
Introducing Susceptibilities: Toward a Cultural Politics of Consent Under Erasure
Authors: Ball Karyn
Published: December 2024

The broad aim of this introduction to a Special Issue on “Susceptibilities: Toward a Cultural Politics of Consent under Erasure” is to broach key questions and research directions that illuminate contemporary public debates about the conditions and limits of conscious intention (and consent as a byproduct thereof), which is typically treated as a “property” that can be “underdeveloped”, “given”, or “taken away”. In keeping with Jacques Derrida’s repudiation of the metaphysics of presence, the perspective animating this essay is that the psychoanalytic standpoint of the unconscious deconstructs the epistemological privilege of determinacy, consistency, and wholeness in treatments of intentional consciousness. Given Jean Laplanche’s attention to the residues of coherent ego fetishism in Sigmund Freud’s oeuvre, the former’s critique of self-sovereignty as evinced in his theorization of the “enigmatic signifier”, “primal repression”, and “afterwardsness” assumes a pivotal role in the analysis of how writers as represented here by Sarah Polley in Run Towards the Danger narrate the vicissitudes of their traumatic memories of sexual assault. Ultimately, then, the implications of this analysis will carry over to brief discussions of this Special Issue’s seven contributions by Melissa Wright, Karen McFadyen, J. Asher Godley, Madeleine Reddon, Gautam Basu Thakur, Robert Hughes, and Rebecca Saunders.
Carbon Fiber-Reinforced Thermoplastic Composite Coatings for Steel Pipelines
Authors: Abd El-Mageed Ahmed I. A. , Desouky Mohamed M. , El-Sayed Mamdouh , Salem Tarek , Radwan Ahmed Bahgat , Hassan Mohammad K. , Al-Oufy Affaf K. , El-Dessouky Hassan M.
Published: December 2024

Steel pipeline systems carry about three-quarters of the world’s oil and gas. Such pipelines need to be coated to prevent corrosion and erosion. An alternative to the current epoxy-based coating, a multi-layered composite coating is developed in this research. The composite coatings were made from carbon fiber-reinforced thermoplastic polymer (CFRTP) material. Uniaxial carbon fiber CF/PPS prepreg tape was utilized, where the PPS (polyphenylene sulfide) is employed as a thermoplastic (TP) matrix. Compression molding was used to manufacture three flat panels, each consisting of seven plies: UD (Unidirectional), Biaxial, and Off-axis. Samples of carbon steel were coated with multi-layered composites. The physical, mechanical, and corrosion-resistant properties of steel-composite coated samples were evaluated. A better and more promising lap-shear strength of about 58 MPa was demonstrated. When compared to the Biaxial and Off-axis samples, the UD assembly had the maximum flexural strength (420 MPa); however, the Biaxial coating has the highest corrosion resistance (445 kΩ·cm2) when compared to the Off-axis and UD coatings.
Nanocomposites Based on Disentangled Ultra-High Molecular Weight Polyethylene: Aspects and Specifics of Solid-State Processing
Authors: Lebedev Oleg V. , Tikunova Ekaterina P. , Kurkin Tikhon S. , Golubev Evgeny K. , Ozerin Alexander N.
Published: December 2024

The stages of solid-state processing of nanocomposites, based on nascent disentangled ultra-high-molecular-weight polyethylene (d-UHMWPE) reactor powders (RPs) and carbon nanoparticles (NPs) of various types, were meticulously investigated. The potential for optimizing the filler distribution through variation of the processing parameters, and the impact of the d-UHMWPE RP and nanofiller type on the electrical conductivity of the resulting composites were discussed. The specifics of the dependences of conductivity and tensile strength on the deformation ratio for the composites, oriented under homogeneous shear conditions, were investigated. The obtained results and the results on piezoresistivity and temperature dependency of conductivity in the oriented and compacted composites demonstrated the independence of the UHMWPE matrix orientational strengthening on the filling. The interchangeability of high-temperature uniaxial deformation and deformation under homogeneous conditions for orientational strengthening and electrical conductivity changes in the preliminary oriented composite samples was confirmed. The potential for simultaneously achieving high strength and conductivity in composite tapes and the possibility of directly processing d-UHMWPE RP and NPs mixtures into oriented composite tapes were demonstrated. The overall results suggest that the studied composites may serve as a viable model system for investigating the deformational behavior of conductive networks comprising NPs of varying types and contents.
An OpenSees Surrogate Constitutive Model for High-Damping Rubber Based on Machine Learning
Authors: Li Feng , Peng Tianbo
Published: December 2024

The complex mechanical properties of high-damping rubber (HDR), a commonly used seismic isolation material in buildings and bridges, present a significant challenge in civil engineering. In a previous study, the authors proposed an HDR constitutive model that combines a Gated Recurrent Unit (GRU) and an attention mechanism, offering novel insights into the mechanical properties of HDR. The constitutive model was simplified first to facilitate the deployment of the proposed constitutive model within the finite element analysis environment. Then, the simplified constitutive model was converted into a uniaxial material format suitable for use within the open system for earthquake engineering simulation (OpenSees). In OpenSees, the uniaxial material was named HDRGA material, and the code for the HDRGA material header and source files was written. Finally, an HDR surrogate constitutive model was developed in OpenSees. To validate the precision of the HDRGA material in characterizing the mechanical attributes of HDR, a two-node model and a single-pier model were devised, and their accuracy was verified through a comparative analysis of test results and nonlinear time history calculation results, respectively. The results demonstrate that the developed HDRGA material is capable of performing well under earthquakes.
Towards Holistic Healing: A Pentecostal Ecotheological Perspective
Authors: Kgatle Mookgo Solomon , Chigorimbo Joshua
Published: December 2024

Pentecostal ecotheology presents a holistic approach to healing that recognises the inherent worth of all creation and the interconnectedness of human and nonhuman creation. It draws on the Pentecostal full gospel and the experiences of biblical Pentecost to inspire an expansive pneumatology that transcends an anthropocentric soteriology and views the entire cosmos as the altar where human and nonhuman creation can tarry for and experience the sacred presence, power, and conviction of the Holy Spirit with a sense of eschatological urgency such that (inter alia) repentance from ecological transgression becomes normative. This framework envisions all of creation participating in the Spirit’s presence, power, gifting, and renewal. Leveraging Pentecostal ecotheology for holistic healing involves intentionally engaging, replicating, and contextualising the pneumatological experiences of the biblical Pentecost. It also involves embracing the pneumatological continuity between us and the biblical charismatic communities, enabling us to administer healing in contemporary environmental contexts through the Spirit’s anointing. Engaging in ecotheological intercession, overcoming the creational desacralisation that leads to the mechanistic exploitation of creation, and adopting a Spirit-born sense of solidarity with creation are further essential strategies for leveraging Pentecostal ecotheology for holistic healing.
Pedro de León Portocarrero’s Descripción del Virreinato del Perú (c.1620): A New Christian Between Spain and Netherlands in Colonial Latin America
Authors: Mordoch Gabriel
Published: December 2024

This essay explores the Descripción del Virreinato del Perú (c.1620), an anonymously authored account of viceregal Peru attributed to Pedro de León Portocarrero (c.1576–c.1620)—a Spanish New Christian merchant likely of Portuguese background. The analysis reveals that Portocarrero’s text undermines Spanish colonial authority not just by supplying secret commercial and military intelligence to Dutch officials but also by subtly critiquing Spain’s colonial enterprise on a symbolic discursive level. Consequently, the work offers an alternative, non-triumphalist, and dissident perspective on the Spanish colonization of Peru.
Assessing Forest Degradation Through Remote Sensing in the Brazilian Amazon: Implications and Perspectives for Sustainable Forest Management
Authors: Oliveira Afonso Henrique Moraes , Matricardi Eraldo Aparecido , de Aragão Luiz Eduardo Oliveira e Cruz , Felix Iara Musse , Chaves José Humberto , Magliano Mauro Mendonça , Oliveira-Junior José Max Barbosa , Vieira Thiago Almeida , Santos Lizandra Elizeário dos , Reis Leonardo Pequeno , Pereira Diogo Otávio Scália , Dias Carlos Tadeu dos Santos , Gama João Ricardo Vasconcellos , Martorano Lucieta Guerreiro
Published: December 2024

Forest degradation and forest disturbance are distinct yet often conflated concepts, complicating their definition and monitoring. Forest degradation involves interrupted succession and a severe reduction in forest services over time, caused by factors like fires, illegal selective logging, and edge effects. Forest disturbance, on the other hand, refers to abrupt, localized events, natural or anthropogenic, such as legal selective logging, tropical blowdowns, storms, or fires, without necessarily leading to long-term degradation. Despite the varying intensity and scale of forest degradation and disturbance, systematic studies distinguishing its types and classes are limited. This study reviews anthropogenic impacts on forests in the Brazilian Amazon, analyzing 80 scientific articles using remote sensing techniques and data. Most research focuses on the “arc of deforestation,” characterized by intense human activity, showcasing methodological advancements but also revealing gaps in monitoring less-studied regions like the central and western Amazon. The findings emphasize the need for advanced remote sensing tools to differentiate degradation types, particularly in sustainable forest management (SFM) contexts. Expanding research to underrepresented regions and refining methodologies are crucial for better understanding forest dynamics and improving conservation strategies. These efforts are essential to support effective forest management and informed policy development across the Amazon.