bluuebunny/crossref_metadata_2025 huggingface dataset:
Machine Learning Prediction Model of Tuberculosis Incidence Based on Meteorological Factors and Air Pollutants
Authors: Tang Na , Yuan Maoxiang , Chen Zhijun , Ma Jian , Sun Rui , Yang Yide , He Quanyuan , Guo Xiaowei , Hu Shixiong , Zhou Junhua
Published: February 2023

Background: Tuberculosis (TB) is a public health problem worldwide, and the influence of meteorological and air pollutants on the incidence of tuberculosis have been attracting interest from researchers. It is of great importance to use machine learning to build a prediction model of tuberculosis incidence influenced by meteorological and air pollutants for timely and applicable measures of both prevention and control. Methods: The data of daily TB notifications, meteorological factors and air pollutants in Changde City, Hunan Province ranging from 2010 to 2021 were collected. Spearman rank correlation analysis was conducted to analyze the correlation between the daily TB notifications and the meteorological factors or air pollutants. Based on the correlation analysis results, machine learning methods, including support vector regression, random forest regression and a BP neural network model, were utilized to construct the incidence prediction model of tuberculosis. RMSE, MAE and MAPE were performed to evaluate the constructed model for selecting the best prediction model. Results: (1) From the year 2010 to 2021, the overall incidence of tuberculosis in Changde City showed a downward trend. (2) The daily TB notifications was positively correlated with average temperature (r = 0.231), maximum temperature (r = 0.194), minimum temperature (r = 0.165), sunshine duration (r = 0.329), PM2.5 (r = 0.097), PM10 (r = 0.215) and O3 (r = 0.084) (p < 0.05). However, there was a significant negative correlation between the daily TB notifications and mean air pressure (r = −0.119), precipitation (r = −0.063), relative humidity (r = −0.084), CO (r = −0.038) and SO2 (r = −0.034) (p < 0.05). (3) The random forest regression model had the best fitting effect, while the BP neural network model exhibited the best prediction. (4) The validation set of the BP neural network model, including average daily temperature, sunshine hours and PM10, showed the lowest root mean square error, mean absolute error and mean absolute percentage error, followed by support vector regression. Conclusions: The prediction trend of the BP neural network model, including average daily temperature, sunshine hours and PM10, successfully mimics the actual incidence, and the peak incidence highly coincides with the actual aggregation time, with a high accuracy and a minimum error. Taken together, these data suggest that the BP neural network model can predict the incidence trend of tuberculosis in Changde City.
The Identification of Potential Immunogenic Antigens in Particular Active Developmental Stages of the Rice Weevil (Sitophilus oryzae)
Authors: Witecka Joanna , Malejky-Kłusek Natalia , Solarz Krzysztof , Pawełczyk Olga , Kłyś Małgorzata , Izdebska Aleksandra , Maślanko Weronika , Asman Marek
Published: February 2023

Background: The rice weevil (Sitophilus oryzae) originates from subtropical and tropical areas of Asia and Africa, but it also appears on other continents, mostly as a result of trade in rice. It may occur in grain fields as well as in storage facilities, and cause allergenic reactions. The aim of this study was to identify the potential antigens in all developmental stages of S. oryzae, which may cause an allergic response in humans. Methods: Sera of 30 patients were tested for the presence of IgE antibodies to antigens from three life stages of the rice weevil. To identify protein fractions containing potential allergens, proteins collected from larvae, pupae, and adults separated by sex of S. oryzae were fractionated by SDS-PAGE. Then, they were probed with anti-human, anti-IgE monoclonal antibodies, fractionated by SDS-PAGE and detected by Western blotting. Results: In total, 26 protein fractions of males and 22 fractions of other life stages of S. oryzae (larvae, pupae, and females) positively reacted with the examined sera. Conclusions: The conducted study showed that S. oryzae may be a source of many antigens which may cause the potential allergic reactions in humans.
Application of Natural and Calcined Oyster Shell Powders to Improve Latosol and Manage Nitrogen Leaching
Authors: Yang Xiaofei , Liu Kexing , Wen Yanmei , Huang Yongxiang , Zheng Chao
Published: February 2023

Excessive N fertilizer application has aggravated soil acidification and loss of N. Although oyster shell powder (OSP) can improve acidic soil, few studies have investigated its ability to retain soil N. Here, the physicochemical properties of latosol after adding OSP and calcined OSP (COSP) and the dynamic leaching patterns of ammonium N (NH4+-N), nitrate N (NO3−-N), and Ca in seepage, were examined through indoor culture and intermittent soil column simulation experiments. Various types of N fertilizer were optimized through the application of 200 mg/kg of N, urea (N 200 mg/kg) was the control treatment (CK), and OSP and COSPs prepared at four calcination temperatures—500, 600, 700, and 800 °C—were added to the latosol for cultivation and leaching experiments. Under various N application conditions, the total leached N from the soil followed ammonium nitrate > ammonium chloride > urea. The OSP and COSPs had a urea adsorption rate of 81.09–91.29%, and the maximum reduction in cumulative soil inorganic N leached was 18.17%. The ability of COSPs to inhibit and control N leaching improved with increasing calcination temperature. Applying OSP and COSPs increased soil pH, soil organic matter, total N, NO3−-N, exchangeable Ca content, and cation exchange capacity. Although all soil enzyme activities related to N transformation decreased, the soil NH4+-N content remained unchanged. The strong adsorption capacities for NH4+-N by OSP and COSPs reduced the inorganic N leaching, mitigating the risk of groundwater contamination.
Liver Dangers of Herbal Products: A Case Report of Ashwagandha-Induced Liver Injury
Authors: Lubarska Marta , Hałasiński Przemysław , Hryhorowicz Szymon , Mahadea Dagmara Santabye , Łykowska-Szuber Liliana , Eder Piotr , Dobrowolska Agnieszka , Krela-Kaźmierczak Iwona
Published: February 2023

In recent years, cases of liver damage caused by ashwagandha herbal supplements have been reported from different parts of the world (Japan, Iceland, India, and the USA). Here, we describe the clinical phenotype of suspected ashwagandha-induced liver injury and the potential causative mechanism. The patient was admitted to the hospital because of jaundice. In the interview, it was reported that he had been taking ashwagandha for a year. Laboratory results showed an increase in total bilirubin, alanine transaminase (ALT), aspartate transaminase (AST), (gamma-glutamyl transpherase (GGT), alkaline phosphatase (ALP), total cholesterol, triglycerides, and ferritin. Based on clinical symptoms and additional tests, the patient was diagnosed with acute hepatitis and referred to a facility with a higher reference rate to exclude drug-induced liver injury. An R-value was assessed, indicative of hepatocellular injury. The result of the 24 h urine collection exceeded the upper limit of normal for copper excretion in urine twice. The clinical condition improved after intensive pharmacological treatment and four plasmapheresis treatments. This case is another showing the hepatotoxic potential of ashwagandha to cause cholestatic liver damage mixed with severe jaundice. In view of several documented cases of liver damage caused by ashwagandha and the unknown metabolic molecular mechanisms of substances contained in it, attention should be paid to patients reporting the use of these products in the past and presenting symptoms of liver damage.
COVID-19 Pandemic: 1-Year Follow-Up in Children and Adolescents with Neuropsychiatric Disorders
Authors: Pastorino Grazia Maria Giovanna , Marino Marianna , Aiello Salvatore , D’Auria Raffaella , Meccariello Rosaria , Santoro Antonietta , Viggiano Andrea , Operto Francesca Felicia
Published: February 2023

Introduction: Few studies have focused on the long-term effects of the COVID-19 pandemic on mental health. The objective of our work was to evaluate the changes in emotional and behavioral symptoms in patients with neuropsychiatric disorders and the impact on parenting stress 1 year after the first national lockdown. Methods: We enrolled 369 patients aged 1.5–18 years of age referred to the Child and Adolescent Neuropsychiatry Unit of the University Hospital of Salerno (Italy) by their parents. We asked their parents to complete two standardized questionnaires for the assessment of emotional/behavioral symptoms (Child Behavior CheckList, CBCL) and parental stress (Parenting Stress Index, PSI) prior to the pandemic (Time 0), during the first national lockdown (Time 1) and after 1 year (Time 2), and we monitored the changes in symptoms over time. Results: After 1 year from the start of the first national lockdown, we found a significant increase of internalizing problems, anxiety, depression, somatization, and social and oppositional-defiant problems in older children (6–18 years), and a significant increase of somatization, anxiety problems, and sleep problems in younger children (1.5–5 years). We also observed a significant relationship between emotional/behavioral symptoms and parental stress. Conclusion: Our study showed that parental stress levels increased compared to the pre-pandemic months and continues to persist over time, while internalizing symptoms of children and adolescents showed a significant worsening during 1 year follow-up from the first COVID-19 lockdown.
Does It Matter Who You Provide Care for? Mental Health and Life Satisfaction in Young Adult Carers Associated with Type of Relationship and Illness Category—A National Student Survey
Authors: Haugland Bente Storm Mowatt , Hysing Mari , Sivertsen Børge
Published: February 2023

There is limited knowledge on how caring contexts impact young adults providing informal care for persons with chronic conditions. This study examines associations between outcomes in young adult carers (YACs) and type of relationship (e.g., close or distant family member, partner, or someone outside the family) and type of illness in the care-receiver (e.g., mental, physical illness/disability, or substance abuse). A total of 37,731 students (age 18–25, mean 22.3 years, 68% females) in higher education in Norway completed a national survey on care responsibilities, hours of daily caring, relationship and type of illness, mental health problems (Hopkins Symptoms Checklist-25) and life satisfaction (Satisfaction With Life Scale). More mental health problems and lower life satisfaction were found among YACs compared to students without care responsibilities. The poorest outcomes were reported by YACs caring for a partner, followed by YACs caring for a close relative. Hours spent on daily caring was highest when caring for a partner. Poorer outcomes were reported by YACs caring for someone affected by substance abuse, followed by mental health problems and physical illness/disability. At-risk groups among YACs should be acknowledged and offered support. Future studies are needed to investigate the potential mechanism for the associations between care context variables and YAC outcomes.
Social Stigma, Mental Health, Stress, and Health-Related Quality of Life in People with Long COVID
Authors: Scholz Urte , Bierbauer Walter , Lüscher Janina
Published: February 2023

A considerable amount of people who have been infected with SARS-CoV-2 experience ongoing symptoms, a condition termed long COVID. This study examined nuanced experiences of social stigma in people with long COVID and their associations with perceived stress, depressive symptoms, anxiety, and mental and physical health-related quality of life (hrqol). A total of N = 253 participants with long COVID symptoms (mean age = 45.49, SD = 12.03; n = 224, 88.5% women) completed a cross-sectional online survey on overall social stigma and the subfacets enacted and perceived external stigma, disclosure concerns, and internalized stigma. Data were analysed using multiple regression and controlling for overall burden of consequences of long COVID, overall burden of symptoms of long COVID, and outcome-specific confounders. In line with our preregistered hypotheses, total social stigma was related to more perceived stress, more depressive symptoms, higher anxiety, and lower mental hrqol, but—in contrast to our hypothesis—it was unrelated to physical hrqol after controlling for confounders. The three subscales of social stigma resulted in differential associations with the outcomes. Social stigma experiences go hand in hand with worse mental health in people with long COVID. Future studies should examine potential protective factors to buffer the effects of social stigma on people’s well-being.
Nutritional Health Knowledge and Literacy among Pregnant Women in the Czech Republic: Analytical Cross-Sectional Study
Authors: Papežová Klára , Kapounová Zlata , Zelenková Veronika , Riad Abanoub
Published: February 2023

Adequate nutrition and the nutritional status of pregnant women are critical for the health of both the mother and the developing foetus. Research has shown a significant impact of nutrition on the child’s health and the future risk of developing chronic noncommunicable diseases (NCDs), such as obesity, diabetes, hypertension, and cardiovascular disease. There is currently no data on the level of nutritional knowledge of Czech pregnant women. This survey aimed to evaluate their level of nutritional knowledge and literacy. An analytical cross-sectional study was conducted in two healthcare facilities in Prague and Pilsen between April and June 2022. An anonymous self-administered paper-form questionnaire for assessing the level of nutritional knowledge (40 items) and the Likert scale for assessing nutrition literacy (5 items) were used. A total number of 401 women completed the questionnaire. An individual’s nutritional knowledge score was calculated and compared with demographic and anamnestic characteristics using statistical methods. The results showed that only 5% of women achieved an overall nutritional score of 80% or more. University education (p < 0.001), living in the capital city (p < 0.001), experiencing first pregnancy (p = 0.041), having normal weight and being overweight (p = 0.024), and having NCDs (p = 0.044) were statistically significantly associated with a higher nutritional knowledge score. The lowest knowledge scores were found in the areas of optimal energy intake, optimal weight gain, and the role of micronutrients in diet during pregnancy. In conclusion, the study shows limited nutrition knowledge of Czech pregnant women in some areas of nutrition. Increasing nutritional knowledge and nutrition literacy in Czech pregnant women is crucial for supporting their optimal course of pregnancy and the future health of their offspring.
Digitalization, Electricity Consumption and Carbon Emissions—Evidence from Manufacturing Industries in China
Authors: Zhang Qian , Wang Qizhen
Published: February 2023

The development of China’s manufacturing industry is constrained by factors such as energy and resources, and low-carbon development is arduous. Digitalization is an important method to transform and upgrade traditional industries. Based on the panel data of 13 manufacturing industries in China from 2007 to 2019, a regression model and a threshold model were used to empirically test the impact of digitalization and electricity consumption on carbon emissions. The research results were as follows: (1) The digitalization level of China’s manufacturing industry was steadily increasing; (2) The proportion of electricity consumption in China’s manufacturing industries in the total electricity consumption hardly changed from 2007 to 2019, basically maintaining at about 6.8%. The total power consumption increased by about 2.1 times. (3) From 2007 to 2019, the total carbon emissions of China’s manufacturing industry increased, but the carbon emissions of some manufacturing industries decreased. (4) There was an inverted U-shaped relationship between digitalization and carbon emissions, the higher the level of digitalization input, the greater the carbon emissions of the manufacturing industry. However, when digitalization develops to a certain extent, it will also suppress carbon emissions to a certain extent. (5) There was a significant positive correlation between electricity consumption and carbon emissions in the manufacturing industry. (6) There were double energy thresholds for the impact of labor-intensive and technology-intensive manufacturing digitalization on carbon emissions, but only a single economic threshold and scale threshold. There was a single scale threshold for capital-intensive manufacturing, and the value was −0.5352. This research provides possible countermeasures and policy recommendations for digitalization to empower the low-carbon development of China’s manufacturing industry.
Intensive Urbanization, Urban Meteorology and Air Pollutants: Effects on the Temperature of a City in a Basin Geography
Authors: Pacheco Patricio , Mera Eduardo , Fuentes Voltaire
Published: February 2023

A qualitative study of thermal transfers is carried out from a record of measurements (time series) of meteorological variables (temperature, relative humidity and magnitude of wind speeds) and pollutants (PM10, PM2.5 and CO) in six localities located at different heights in the geographic basin of Santiago de Chile. The measurements were made in two periods, 2010–2013 and 2017–2020 (a total of 2,049,336 data), the last period coinciding with a process of intense urbanization, especially high-rise construction. The measurements, in the form of hourly time series, are analyzed on the one hand according to the theory of thermal conduction discretizing the differential equation of the temporal variation in the temperature and, on the other hand, through the theory of chaos that provides the entropies (S). Both procedures demonstrate, comparatively, that the last period of intense urbanization presents an increase in thermal transfers and temperature, which affects urban meteorology and makes it more complex. As shown by the chaotic analysis, there is a faster loss of information for the period 2017–2020. The consequences of the increase in temperature on human health and learning processes are studied.
N-Source Determines Barley Productivity, Nutrient Accumulation, and Grain Quality in Cyprus Rainfed Agricultural Systems
Authors: Omirou Michalis , Fasoula Dionysia , Stylianou Marinos , Zorpas Antonis A. , Ioannides Ioannis M.
Published: February 2023

The Eastern Mediterranean and Middle East (EMME) region is already experiencing the negative effects of increased temperatures and the increase in prolonged drought periods. The use of organic fertilization could be a valuable tool to meet the main challenges of climate change and maintain the productivity, quality, and sustainability of rainfed agricultural ecosystems. In the current study, we compare the effect of manure, compost, and chemical fertilization (NH4NO3) on barley grain and straw yield in a field study for three consecutive growing seasons. The hypothesis that the barley productivity, nutrient accumulation, and grain quality remain similar among the different nutrient management strategies was tested. The results showed that both growing season and type of nutrient source significantly affected barley grain and straw yield (F6,96 = 13.57, p < 0.01). The lowest productivity was noticed in the non-fertilized plots while chemical and organic fertilization exhibited similar grain yield, ranging from 2 to 3.4 t/ha throughout the growing seasons. For straw, the use of compost had no effect on the yield in any of the growing seasons examined. The use of manure and compost had a significant effect on grain macro- and micronutrient content but this was highly related to growing season. Principal component analysis (PCA) clearly demonstrated the discrimination of the different type of fertilization on barley performance during the course of the study, while the application of compost was highly associated with an increase in micronutrients in grain samples. Furthermore, structural equational modeling (SEM) showed that both chemical and organic fertilization had a direct positive effect on macro- (r = 0.44, p < 0.01) and micronutrient (r = 0.88, p < 0.01) content of barley grain and a positive indirect effect on barley productivity through N accumulation in grain (β = 0.15, p = 0.007). The current study showed that barley grain and straw yield was similar between manure and NH4NO3 treatments, while compost exhibited a residual positive effect causing an increase in grain yield during the growing season. The results highlight that N fertilization under rainfed conditions is beneficial to barley productivity through its indirect effects on N accumulation in grain and straw, while it improves grain quality through the increased accumulation of micronutrients.
Increased Prolonged Sitting in Patients with Rheumatoid Arthritis during the COVID-19 Pandemic: A Within-Subjects, Accelerometer-Based Study
Authors: Pinto Ana Jessica , Rezende Diego , Sieczkowska Sofia Mendes , Meireles Kamila , Bonfiglioli Karina , Ribeiro Ana Cristina de Medeiros , Bonfá Eloisa , Owen Neville , Dunstan David W. , Roschel Hamilton , Gualano Bruno
Published: February 2023

Background: Social distancing measures designed to contain the COVID-19 pandemic can restrict physical activity, a particular concern for high-risk patient groups. We assessed rheumatoid arthritis patients’ physical activity and sedentary behavior level, pain, fatigue, and health-related quality of life prior to and during the social distancing measures implemented in Sao Paulo, Brazil. Methods: Post-menopausal females diagnosed with rheumatoid arthritis were assessed before (from March 2018 to March 2020) and during (from 24 May to 7 July 2020) social distancing measures to contain COVID-19 pandemic, using a within-subjects, repeated-measure design. Physical activity and sedentary behavior were assessed using accelerometry (ActivPAL micro). Pain, fatigue, and health-related quality of life were assessed by questionnaires. Results: Mean age was 60.9 years and BMI was 29.5 Kg/m2. Disease activity ranged from remission to moderate activity. During social distancing, there were reductions in light-intensity activity (13.0% [−0.2 h/day, 95% CI: −0.4 to −0.04; p = 0.016]) and moderate-to-vigorous physical activity (38.8% [−4.5 min/day, 95% CI: −8.1 to −0.9; p = 0.015]), but not in standing time and sedentary time. However, time spent in prolonged bouts of sitting ≥30 min increased by 34% (1.0 h/day, 95% CI: 0.3 to 1.7; p = 0.006) and ≥60 min increased by 85% (1.0 h/day, 95% CI: 0.5 to 1.6). There were no changes in pain, fatigue, and health-related quality of life (all p > 0.050). Conclusions: Imposed social distancing measures to contain the COVID-19 outbreak were associated with decreased physical activity and increased prolonged sedentary behavior, but did not change clinical symptoms sitting among patients with rheumatoid arthritis.
A Head-to-Head Comparison of Two Algorithms for Adjusting Mealtime Insulin Doses Based on CGM Trend Arrows in Adult Patients with Type 1 Diabetes: Results from an Exploratory Study
Authors: Parise Martina , Di Molfetta Sergio , Graziano Roberta Teresa , Fiorentino Raffaella , Cutruzzolà Antonio , Gnasso Agostino , Irace Concetta
Published: February 2023

Background: Continuous glucose monitoring (CGM) users are encouraged to consider trend arrows before injecting a meal bolus. We evaluated the efficacy and safety of two different algorithms for trend-informed bolus adjustments, the Diabetes Research in Children Network/Juvenile Diabetes Research Foundation (DirectNet/JDRF) and the Ziegler algorithm, in type 1 diabetes. Methods: We conducted a cross-over study of type 1 diabetes patients using Dexcom G6. Participants were randomly assigned to either the DirectNet/JDRF or the Ziegler algorithm for two weeks. After a 7-day wash-out period with no trend-informed bolus adjustments, they crossed to the alternative algorithm. Results: Twenty patients, with an average age of 36 ± 10 years, completed this study. Compared to the baseline and the DirectNet/JDRF algorithm, the Ziegler algorithm was associated with a significantly higher time in range (TIR) and lower time above range and mean glucose. A separate analysis of patients on CSII and MDI revealed that the Ziegler algorithm provides better glucose control and variability than DirectNet/JDRF in CSII-treated patients. The two algorithms were equally effective in increasing TIR in MDI-treated patients. No severe hypoglycemic or hyperglycemic episode occurred during the study. Conclusions: The Ziegler algorithm is safe and may provide better glucose control and variability than the DirectNet/JDRF over a two-week period, especially in patients treated with CSII.
Effect of Culture Conditions of Lophocereus marginatus Endophytic Fungi on Yield and Anticancer and Antioxidant Activities
Authors: Ramírez-Villalobos Jesica María , Gomez-Flores Ricardo , Velázquez-Flores Priscilla Viridiana , Morán-Santibáñez Karla Selene , Tamez-Guerra Patricia , Pérez-González Orquídea , de la Garza-Ramos Myriam Angélica , Rodríguez-Padilla Cristina , Romo-Sáenz César Iván
Published: February 2023

Culture conditions affect the production of secondary metabolites in endophytic fungi. Therefore, the aim of the present study was to evaluate the yield and anticancer and antioxidant activity of endophytic fungi extracts from the cactus Lophocereus marginatus, under different culture conditions. The strains Penicillium citrinum, Aspergillus versicolor, Metarhizium anisopliae, and Cladosporium sp. were fermented in different culture media (potato dextrose agar, Czapeck broth, and malt broth), types of inoculums (spore or mycelium), and shaking conditions (150 rpm or static) for one week. Methanol extracts were obtained from mycelia, which was followed by determining their yields and evaluating their effect on L5178Y-R murine lymphoma cells growth and human peripheral blood mononuclear cells (PBMCs) viability, using the 3-[4,5dimethylthiazol-2-yl]2,5-diphenyl tetrazolium bromide reduction colorimetric assay. In addition, antioxidant activity was determined by the 2,2-diphenyl-1-picrylhydrazyl test. We determined the half-maximal inhibitory concentration (IC50) values of tumor cell growth inhibition, the selectivity index (SI), and the antioxidant activity, as compared with the healthy cells control. The best yields were obtained with the Czapeck broth medium in all the evaluated strains, reaching values of 50.3%. Of the 48 extracts evaluated, only seven significantly (p < 0.01) inhibited tumor cell growth (IC50 < 250 µg/mL). A. versicolor extract showed the highest anticancer activity, after culturing spores (IC50 = 49.62 µg/mL; SI = 15.8) or mycelium (IC50 = 69.67 µg/mL; SI = 12.2) in malt broth, under static conditions. Extracts did not present significant antioxidant activity. In conclusion, we showed that culture conditions influenced the anticancer activity of L. marginatus endophytic fungi.
Marshallese Mothers’ and Marshallese Maternal Healthcare Providers’ Perspectives on Contraceptive Use and Reproductive Life Planning Practices and Influences
Authors: Ayers Britni L. , Purvis Rachel S. , Callaghan-Koru Jennifer , Reece Sharon , CarlLee Sheena , Manning Nirvana , Langston Krista , Riklon Sheldon , McElfish Pearl A.
Published: February 2023

Pacific Islander communities experience significant maternal and infant health disparities including high maternal and infant mortality. Contraception and reproductive life planning prevent approximately one-third of pregnancy-related deaths and neonatal deaths. We report the results of formative research devoted to understanding Marshallese mothers’ as well as their maternal healthcare providers’ practices and influences related to contraceptive use and reproductive life planning. This study used an exploratory, descriptive qualitative design to explore Marshallese mothers’ and maternal healthcare providers’ practices and influences of contraception use and reproductive life planning. Twenty participants were enrolled in the study, 15 Marshallese mothers and five Marshallese maternal healthcare providers. For the Marshallese mothers, two themes emerged: (1) Reproductive Life Planning Practices and Information; and (2) Reproductive Life Planning Influences. For the Marshallese maternal healthcare providers, two themes emerged: (1) Reproductive Life Planning Practices; and (2) Reproductive Life Planning Influences. This is the first study to document Marshallese mothers’ and maternal healthcare providers’ practices and influences with contraceptive use and reproductive life planning. Study results will inform the development of a culturally-adapted contraception and reproductive life planning tool with an educational program for Marshallese family units and maternal healthcare providers serving Marshallese women.
Bacterial Colonization of Microplastics at the Beaches of an Oceanic Island, Tenerife, Canary Islands
Authors: Hernández-Sánchez Cintia , Pestana-Ríos Ángel Antonio , Villanova-Solano Cristina , Domínguez-Hernández Cristopher , Díaz-Peña Francisco Javier , Rodríguez-Álvarez Cristobalina , Lecuona María , Arias Ángeles
Published: February 2023

(1) Isolated systems, such as oceanic islands, are increasingly experiencing important problems related to microplastic debris on their beaches. The formation of microbial biofilm on the surface of microplastics present in marine environments provides potential facilities for microorganisms to survive under the biofilm. Moreover, microplastics act as a vehicle for the dispersion of pathogenic organisms, constituting a new route of exposure for humans. (2) In this study, the microbial content (FIO and Vibrio spp. and Staphylococcus aureus) of microplastics (fragments and pellets) collected from seven beaches of the oceanic island of Tenerife, in the Canary Islands (Spain), was determined. (3) Results showed that Escherichia coli was present in 57.1% of the fragments and 28.5% of the pellets studied. In the case of intestinal Enterococci, 85.7% of the fragments and 57.1% of the pellets tested positive for this parameter. Finally, 100% of the fragments and 42.8% of the pellets analyzed from the different beaches contained Vibrio spp. (4) This study shows that microplastics act as reservoirs of microorganisms that can increase the presence of bacteria indicating faecal and pathogenic contamination in bathing areas.
The Impact of the COVID-19 Pandemic on Quality Education of the Medical Young Generation
Authors: Matasariu Daniela Roxana , Lozneanu Ludmila , Bujor Iuliana Elena , Cristofor Alexandra Elena , Mandici Cristina Elena , Găină Marcel Alexandru , Ștefănescu Cristinel , Boiculese Vasile Lucian , Popescu Ioana , Stătescu Laura , Rusu Andreea , Giusca Simona Eliza , Ursache Alexandra
Published: February 2023

(1) Generating the need to impose social distancing to reduce the spread of the virus, the COVID-19 pandemic altered the ways in which the teaching process normally happens. The aim of our study was to determine the impact of online teaching on medical students during this period. (2) Our study included 2059 medical, dental and pharmacy students from the University of Medicine and Pharmacy “Grigore T. Popa”, Iasi, Romania. We used a modified metacognition questionnaire after translation into Romanian and validation. Our questionnaire included 38 items, and it was divided into four parts. Academic results and preferences regarding the on-site or online courses, information regarding practical training, self-awareness in terms of one’s feelings such as anger, boredom and anxiety and also substance use linked to online teaching, and contextualization of the relationship with colleagues, teachers, friends and family were among the most important points evaluated. A comparison was made between preclinical and clinical students. A five-item Linkert-like scale was used for rating the answers in the last three parts that evaluated the impact of the SARS-CoV-2 pandemic on the educational process. (3) Preclinical medical students, compared to preclinical dental students, obtained statistically significant improvements in their evaluation results, with fewer failed exams (p < 0.001) and with similar results being obtained by comparing dental with pharmacy students. All students obtained statistically significant improvements in their academic results during the online evaluation. A statistically significant increase in anxiety and depression with a p-value of <0.001 was registered among our students. (4) The majority found it difficult to cope with this intense period. Both teachers and students found it difficult to adjust on such short notice to the challenges posed by the new concept of online teaching and learning.
Colles’ Fracture: An Epidemiological Nationwide Study in Italy from 2001 to 2016
Authors: Longo Umile Giuseppe , De Salvatore Sergio , Mazzola Alessandro , Salvatore Giuseppe , Mera Barbara Juliette , Piergentili Ilaria , Denaro Vincenzo
Published: February 2023

The present study aimed to evaluate the yearly number of Colles’ fractures in Italy from 2001 to 2016, based on official information found in hospitalization records. A secondary aim was to estimate the average length of hospitalization for patients with a Colles’ fracture. A tertiary aim was to investigate the distribution of the procedures generally performed for Colles’ fractures’ treatment in Italy. An analysis of the National Hospital Discharge records (SDO) maintained at the Italian Ministry of Health, concerning the 15 years of our study (from 2001 to 2016) was performed. Data are anonymous and include the patient’s age, sex, domicile, length of hospital stays (days), primary diagnoses and primary procedures. From 2001 to 2016, 120,932 procedures for Colles’ fracture were performed in Italy, which represented an incidence of 14.8 procedures for every 100,000 adult Italian inhabitants. The main number of surgeries was found in the 65–69- and 70–74-year age groups. In the present study, we review the epidemiology of Colles’ fractures in the Italian population, the burden of the disease on the national health care system (in terms of length of hospitalization) and the distribution of the main surgical procedures performed for the treatment of the disease.
Sustainable Ecosystem Services of a Time-Honored Artificial River Ecosystem—Enlightenments from the Carp Brook, in Northern Fujian Province, China
Authors: Li Yuliang , Yi Ran , Liu Lin , Chen Feng
Published: February 2023

Building a harmonious relationship between human society and river ecosystems has attracted much attention from both government officials and the academy community. Based on the perspective of social-ecological systems (SES), taking the Carp Brook (located in northern Fujian Province, China) as an example, the construction and maintenance of a time-honored artificial river ecosystem was investigated, and its ecosystem services were analyzed. Findings show that the Carp Brook was constructed through a series of ecological engineering, including a transformation of the river channel, building a stable habitat, and breeding carps. The carps have been protected effectively by some folk customs, such as village regulations and folk belief. Meanwhile, the water quality has been maintained through some engineering and institutional measures, which were completed by the local government and villagers. Furthermore, some cultural elements with local characteristics have been formed during the long years of coexistence between human society and the Carp Brook. Based on a healthy ecosystem and abundant culture elements, the Carp Brook provided continuous ecosystem services to human society for more than 800 years, including regulation services (e.g., water purification and flood control) and cultural services (e.g., tourism, research and education, inspiration). Major enlightenments from the Carp Brook are: (a) the Chinese traditional view of nature is important for the construction and maintenance of an artificial ecosystem; (b) traditional folk customs have a strong binding force regarding the protection of the ecosystem; and (c) the choice between material and immaterial services should be made carefully.
The Inhibition and Equilibrium of Policy Effectiveness of the Low-Carbon Economy: Evidence from Liaoning Province of China
Authors: Chen Rongxin , Shi Xinyuan
Published: February 2023

Excessive emissions of carbon dioxide and other greenhouse gases have seriously affected the ecological environment, public health, and the normal operation of the social economy, and the development of the low-carbon economy has become an international consensus. The policy norms are one of the important factors affecting the development of the low-carbon economy; however, the implementation of low-carbon economic policy in many countries has been inhibited. This study chose Liaoning Province of China for the case study, and the policy system, the policy tools, the administrative system, the low-carbon technology, and the low-carbon concept are found to be factors that led to the inhibition of the policy effectiveness of the low-carbon economy in Liaoning Province. We applied the modified Schweller Neoclassical Realist Theory to establish a multi-factor linkage model to demonstrate the overall relationship among various variables. The results show that the equilibrium of policy effectiveness of the low-carbon economy in Liaoning Province depends on different permutations of variables. We also discussed the problems of the policy system, the policy tools, the administrative system, the low-carbon technology, and the low-carbon concept that lead to policy effectiveness inhibition, and used the economic method to set a special mathematical model for maximizing the equilibrium of policy effectiveness of the low-carbon economy in Liaoning Province. In response to the problems of the above factors, strategies to promote the development of the low-carbon economy in Liaoning Province are proposed. This study enriches the research on the policy effectiveness of the low-carbon economy in China and provides some inspiration for the goal of carbon neutrality and other developing countries with high carbon emissions.
Trends in Health Behavior of Polish Women in 1986–2021: The Importance of Socioeconomic Status
Authors: Lopuszanska-Dawid Monika
Published: February 2023

In the last 35 years Poland has undergone a series of fundamental economic, social, and biological transformations. With the transition from a centrally planned to a free-market economy, a period of economic and social transformation, Poland’s accession to the European Union, and the COVID-19 coronavirus pandemic, living conditions in the country have seen dramatic changes. The aim of this study was to assess whether there were changes in the basic health behaviors of Polish women, and if so, in what directions and with what strength, and whether there were differences in these changes depending on the socioeconomic status. Information on basic lifestyle factors (drinking alcohol, smoking, coffee drinking, and physical activity) and socioeconomic status (level of education, Gini coefficient, Gender Inequality Index, women total employment, employed women being in managerial positions, women among scientists) of 5806 women aged 40–50 years were analyzed. During the 1986–2021 period, based on the same methodology, team of technicians and research tools, six birth cohorts of women were examined in 1986, 1991, 1996, 2006, 2019 and 2021. Highly statistically significant changes were found in the frequencies of declared health behaviors from 1986–2021, according to the order of significance in coffee and alcohol consumption, physical activity levels, and smoking and smoking intensity. In subsequent cohorts, there were fewer and fewer women who did not drink coffee and alcohol, while more drank more than two cups of coffee a day and drank alcohol more often than 2× a week. Furthermore, they were more likely to be physically active, and slightly fewer were smokers. The lifestyles of the women were less likely to depend on their socio-economic status than the cohorts. In 1991 and 1996, there was a marked intensification of unhealthy behavior. Changes in the analyzed health behaviors may have been caused by adaptation to the high level of psychosocial stress observed during the transition of the 1986–2021 period and may result in changes in the biological condition and quality and length of life of Polish women. Research on social differences in health behavior provides an opportunity to analyze the biological effects of changes in the living environment.
Parental Stress in Raising a Child with Developmental Disabilities in a Rural Community in South Africa
Authors: Mbatha Nontokozo Lilian , Mokwena Kebogile Elizabeth
Published: February 2023

Although acceptable levels of parental stress are experienced by all parents who raise children, this stress is substantially higher among parents who raise children with developmental disabilities. Sociodemographic determinants further exacerbate parental stress among parents in rural communities, which are disadvantaged in many ways. This study aimed to quantify parental stress among mothers and female caregivers of children with developmental disorders and investigate factors associated with such stress in rural Kwa-Zulu Natal, South Africa. A cross-sectional quantitative survey was used, in which the Parenting Stress Index-Short Form (PSI-SF) and a sociodemographic questionnaire was administered to mothers and caregivers who were raising children aged 1 to 12 years old who were living with developmental disabilities. The PSI-SF scores were used, where a total score of ≤84 percentile was categorised as normal/no parenting stress, 85–89 percentile was categorised as high parental stress, and scores of ≥90 were classified as clinically significant. The sample of 335 participants consisted of 270 (80.6%) mothers and 65 (19.4%) caregivers. Their ages ranged from 19 to 65 years, with a mean of 33.9 (±7.8) years. The children were mostly diagnosed with delayed developmental milestones, communication difficulties, epilepsy, cerebral palsy, autism, ADHD, cognitive impairment, sensory impairments, and learning difficulties. The majority (52.2%) of the participants reported very high-clinically significant stress levels (≥85%ile). The four factors that independently and significantly predicted high parental stress were the advanced age of mothers and caregivers (p = 0.002, OR 2.3, 95% CI 1.34–3.95), caring for a child with multiple diagnoses (p = 0.013, OR 2.0, 95% CI 1.16–3.50), non-school enrolment of the child (p = 0.017, OR 1.9, 95% CI 1.13–3.46), and frequent hospital visits (p = 0.025, OR 1.9, 95% CI 1.09–3.44). At the subscale level, child non-enrolment in a school was found to independently predict parent distress (PD) and parent-child dysfunctional interaction (P-CDI). Frequent hospital visits were statistically and significantly associated with the difficult child (DC) and P-CDI subscales. The study established high parental stress in mothers and caregivers raising children with developmental disabilities. Lack of access to school was an independent factor that consistently increased parental stress. There is a need for support and directed intervention programs aimed at supporting mothers and caregivers of children with developmental disabilities, which will enhance their parenting abilities.
Attention and Sentiment of the Chinese Public toward a 3D Greening System Based on Sina Weibo
Authors: Zhao Wenlu , Jin Guanghu , Huang Chenyue , Zhang Jinji
Published: February 2023

The rapid development of global urbanization over the years has led to a significant increase in the urban population, resulting in an imbalance in the urban green space structure. Transforming the urban 2D space green quantity into a 3D space green quantity to create 3D greenery systems (TGS) is a space resource that cannot be ignored in the process of urban green space expansion. This research gathered and analyzed Sina Weibo post information and user information related to TGS to investigate the changing trend of attention status and emotional orientation of the Chinese public on TGS. We employed web crawler technology and text mining to search and analyze the data on the Sina Weibo platform. This research aids policymakers and stakeholders in comprehending the general public’s perspective on TGS and showing the transmission channel of public sentiment and the origins of negative sentiment. Results indicate that the public’s attention to TGS has greatly increased since the shift in the government’s idea of governance, although it still needs improvement. Despite TGS’s good thermal insulation and air purification effects, 27.80% of the Chinese public has a negative attitude toward it. The public’s negative sentiment of TGS housing is not solely due to pricing. The public is mainly concerned about the damage to the structure of buildings caused by TGS, the subsequent maintenance of plants, the increase in indoor mosquitoes, and lighting and humidity problems. This research helps decision makers understand the public opinion communication process via social media and provides corresponding solutions, which is of great significance for the future development of TGS.
“INTEGRO INTEGRated Psychotherapeutic InterventiOn” on the Management of Chronic Pain in Patients with Fibromyalgia: The Role of the Therapeutic Relationship
Authors: Pasini Ilenia , Perlini Cinzia , Donisi Valeria , Mason Anna , Schweiger Vittorio , Secchettin Erica , Lugoboni Fabio , Valenza Gaetano , Del Piccolo Lidia
Published: February 2023

Fibromyalgia (FM) is a chronic disease characterized by a heterogeneous set of physical and psychological conditions. The chronic experience of disability felt by patients and the impact on quality of life (QoL) of the disease may worsen the cognitive reappraisal ability and contribute to maintaining an altered pain modulation mechanism. This paper presents the study protocol of an INTEGRated psychotherapeutic interventiOn on the management of chronic pain in patients with fibromyalgia (INTEGRO). The aim of the study is to investigate the efficacy of an integrated psychotherapeutic intervention focused on pain management on QoL and pain perception, in a pilot sample of 45 FM patients with idiopathic chronic pain. The contribution of perceived therapeutic relationship (alliance) and physiological attunement, in both the patient and therapist, will be considered as possible mediators of intervention efficacy. Attachment dimensions, traumatic experiences, difficulties in emotion regulation, mindfulness attitude and psychophysiological profile will also be considered as covariates. The objectives are to evaluate longitudinally if patients will experience an increase in QoL perception (primary endpoint), pain-managing self-efficacy and emotion-regulation abilities as well as a reduction in pain intensity (secondary endpoints), considering the mediating role of perceived therapeutic alliance and physiological attunement in both the patient and therapist.