bluuebunny/crossref_metadata_2025 huggingface dataset:
Preoperative serum prealbumin levels in predicting postoperative complications and survival in malignant bowel obstruction surgery
Authors: Weng Zongqi , Lai Jinhong , Wang Kangmei , Chen Zishan , Chen Hongbin , Yu Hongxi , Chen Xianqiang , Lin Yuyuan , Lin Mengxin , Pan Jie
Published: February 2024

Purpose This study aims to assess the predictive value of preoperative prealbumin (PA) concentration in cases of Malignant bowel obstruction (MBO) for postoperative complications and long-term survival.
Methods Single-factor and multi-factor logistic regression analyses were performed to identify independent risk factors for severe complications and infectious complications. Simultaneously, single-factor and multi-factor Cox regression analyses were employed to identify independent risk factors for overall survival (OS), and corresponding nomograms were created. Kaplan-Meier survival curves were generated for grouped data with statistically significant differences. The area under the curve (AUC) was compared to assess the testing efficiency of different nutritional indicators for postoperative severe complications.
Results There was a statistically significant difference in the comparison of overall complications and infectious complications between the two groups in different CD grades (p＜0.001). Specifically, the incidence of CD≥3 in the super-low PA group was higher (p＜0.001), and a gradual increase in the severity of overall and infectious complications postoperatively was observed with decreasing PA levels (p＜0.001). PA (p<0.001) and intestinal stent placement (p=0.015) were identified as independent influencing factors for early postoperative severe complications (CD≥3), while PA was an independent influencing factor for postoperative infectious complications (p<0.001). PA, gender, surgical approach, TNM staging, and postoperative chemotherapy were identified as independent predictors of overall survival (OS). Compared to indicators like FPR and AFP, PA demonstrated the highest testing efficiency (AUC=0.888).
Conclusion Preoperative PA has significant predictive value for early postoperative complications and overall survival in MBO,providing new insights into perioperative nutritional intervention and surgical approach selection for MBO patients.
HFTDAO: Hybrid Fuzzy-based Tasmanian Devil Arithmetic Optimization for Trust worthy Data Communication in the WSN
Authors: R Uma Mageswari , TF Michael Raj , M Gowthul Alam M , S Jerald Nirmal Kumar
Published: February 2024

Wireless sensor networks (WSN) play a significant role in various applications as a communication framework in the field of the Internet of things (IoT). Secure data communication over unsteady wireless connections becomes the main concern in WSN. In order to assure reliable and secure data delivery, numerous research works use authentication-based opportunistic routing protocols. However, it is identified that opportunistic routing protocols are more susceptible to cyber security attacks; particularly, Denial of service (DoS) attacks which causes network failures by disrupting the normal operation of the wireless network. Therefore, in this paper, we propose a novel trust-based routing protocol to safeguard the network from DoS attacks by providing better reliability and authenticity to the wireless channels. The proposed hybrid fuzzy-based Tasmanian devil arithmetic optimization (HFTDAO) algorithm analyzes the historic data information of wireless links and selects the optimal routing channel based on link trust. The novelty of the HFTDAO algorithm is, it utilizes the exploration ability of the Tasmanian devil algorithm and the exploitation ability of arithmetic optimization to enhance the searching ability of the algorithm; the exploring behavior is mechanically shifted among them by means of the tendency factor. In contrast to existing routing protocols, the proposed trust-based opportunistic routing protocol enhances the effectiveness of data delivery. The utilization of mutual authentication algorithm avoids invalid or unreliable data communication directed by DoS attacks and thus provides better data integrity. Also, the verification scheme performed before data delivery speeds up the isolation process of the DoS attack. The efficiency of the proposed model is compared with the existing techniques in terms of different performance metrics such as using different performance measures including PDR (Packet Delivery Ratio), the number of verifications, end-to-end latency, and control packet overhead. When compared to other approaches, the proposed HFTDAO algorithm has a very high throughput value, DoS attack identification rate, and packet delivery ratio.
Candiduria in The Patients Visiting at Kathmandu Model Hospital, Nepal
Authors: Shrestha Santosh , Bhandari Nirajan , Gopali Bipin , Pandey Bibek , Thapa Pushkar , Shrestha Basudha , Amatya Niroj Man
Published: February 2024

The effective management of Candiduria depends upon proper identification of Candida species and their antifungal susceptibility test. Therefore, this cross-sectional study is conducted to assess the occurrence of different Candida species in urine and to determine their antifungal susceptibility pattern from productive age group 15-65. The isolation and identification of Candida species from clean catch midstream urine were done by culturing on Sabouraud Dextrose Agar with chloramphenicol followed by germ tube test, sugar fermentation test, chlamydospore production test, and further differentiated by using CHROM agar. The antifungal susceptibility test was done on Muller Hinton Agar with 2% glucose and 0.5 µg/mL methylene blue, and result interpretation was done as recommended to CLSI guidelines (M 44-A2). From 586 urine samples, 45 Candida species were isolated in which the predominant one is C. parapsilosis (14, 31.1%) followed by C. albicans (12, 26.6%). The antifungal susceptibility test showed that fluconazole resistant (29.41%) was comparatively more than voriconazole (21.87%). Since non albicans Candida are emerging pathogen and its antifungal resistant pattern is hiking, it is crucial to incorporate fungus identification in routine testing and identify their antifungal susceptibility pattern to ensure effective treatment and monitor for any antifungal resistance.
Characteristics and outcomes of ECMO cannula-related infections: a European multicenter retrospective study
Authors: Ortuno Sofia , Massart Nicolas , Vidal Charles , de Montmollin Etienne , Bouglé Adrien , Nesseler Nicolas , Bidar Frank , Assouline Benjamin , Masi Paul , Henri Samuel , Hraiech Sami , Rozé Hadrien , Manicone Francesca , Luyt Charles-Edouard
Published: February 2024

Purpose
Only few data regarding epidemiology and management of ECMO cannula-related infections (CRIs) exist. The aim of our study was to describe their epidemiology and prognosis, and to evaluate factors associated with outcome.
Methods
We performed a multicenter retrospective study in 12 European ICUs, including patients with CRI, defined as a clinical suspicion plus a positive bacterial sample of ECMO-cannulation site. Primary objective was to describe CRI characteristics and outcomes. Secondary objectives were to evaluate the rates of infection recurrence, their risk factors, and to evaluate the impact of antimicrobial treatment duration on outcome.
Results
During the study period, 124 patients with CRI (78 having concomitant positive blood culture with the same pathogen) were included. Pathogens responsible for infections were predominantly Enterobacteriaceae, coagulase-negative Staphylococcus and Enterococcusspp., and 40% of episodes were polymicrobial. Rates of infection recurrence was 24% and ICU-mortality rate was 50%. Whereas veno-venous ECMO (as compared to veno-arterial ECMO), and therefore ECMO duration was associated with infection recurrence, characteristics of CRI and its management (and in particular duration of antimicrobial treatment) were not associated with recurrence. Patients with antibiotic course ≤8 days had similar infection recurrence rate and outcomes (including mortality) than patients with prolonged (>8 days) antibiotic course.
Conclusion
CRIs are frequently associated with BSI and frequently polymicrobial. Main risk factor of infection recurrence is ECMO duration. Duration of antimicrobial treatment for CRI ≤8 days is not associated with an increased risk of recurrence or death, as compared to longer treatment.
A Multi-Objective Approach for Optimizing IoT Applications Offloading in Fog-Cloud Environments with NSGA-II
Authors: mokni ibtissem , Yassa Sonia
Published: February 2024

Internet of Things (IoT) applications have gained widespread adoption across diverse sectors such as healthcare, smart agriculture, smart cities, transportation, and water management, leading to a substantial generation of Big Data. To efficiently process this voluminous data, there is a pressing need for a platform capable of handling large quantities. However, real-time applications face challenges in cloud processing due to high latency. Fog computing, serving as a complementary infrastructure to the cloud, emerges as a viable solution by facilitating task processing, networking, and data storage in cloud data centers accessible to mobile users.
Task offloading emerges as a promising fog computing solution to overcome resource constraints in IoT applications. This involves the execution of part or all of mobile applications in the cloud, aiming to enhance execution time and reduce energy consumption. Our research concentrates on optimizing the IoT task offloading problem within heterogeneous environments, considering conflicting constraints. This optimization challenge is formulated as a multi-objective problem, emphasizing energy consumption and latency Quality of Service (QoS) metrics. Our proposed solution, named Tof-NSGAII, is tailored to respect the finite resources of fog computing by adeptly balancing workloads and meeting the latency requirements of IoT tasks.
We have adapted the widely employed meta-heuristic, the non-dominant sorting genetic algorithm (NSGA-II), to generate a set of non-dominated multi-objective task offloading optimization solutions, considering both energy consumption and latency. Experimental results showcase the efficacy of Tof-NSGAII in generating task offloading solutions that judiciously distribute executed tasks between fog and cloud computing environments based on their specific requirements. Additionally, the generated non-dominated solutions demonstrate optimality in terms of energy consumption, boasting an average energy reduction of 12.18\% compared to alternative approaches. Notably, our approach introduces only a marginal increase in latency, amounting to 0.38\%, a difference that can be considered negligible.
Relationship between the Menstrual Cycle and Sexual Activity: Maybe Women Do Not Lose Estrus
Authors: Tarlacı Sultan , Koyuncu Safiye Ayça , Şan Oğuzhan
Published: February 2024

The menstrual cycle and women sexuality have long been an area of ​​research to understand both evolutionary and hormonal influences. This study examined the relationship between menstrual cycle and libido in women with regular menstrual cycles. Two different studies were conducted for this purpose. In the first study, 489 women were surveyed and asked about the day of their menstrual cycle and their libido and sexual activities on the day of the survey. In the second study, 25 women provided a daily diary throughout their one menstrual cycle, and their daily libido scores, whether they masturbated, and rate of initiating sexual activity with their partner were determined. All data were analyzed before and after ovulation and sub-analyses made for periods close to ovulation. We found in both studies were that sexual libido and its behavioral reflections increased before and immediately after ovulation. However, the findings also reveal the complexity of the menstrual cycle and women sexuality.
Dermal papilla cell-derived exosomes promote hair follicle regeneration during wound healing by activating Wnt/β‐catenin signaling pathway
Authors: Shang Yage , Li Mengyang , Zhang Lixia , Han Chao , Shen Kuo , Wang Kejia , Li Yan , Zhang Yue , Luo Liang , Jia Yanhui , Guo Kai , Cai Weixia , Zhang Jian , Wang Xujie , Wang Hongtao , Hu Dahai
Published: February 2024

Hair follicle (HF) regeneration after skin injury remains a major clinical challenge. Dermal papilla cell-derived exosomes (DPC-Exos) have great potential to induce HF neogenesis. However, the role and mechanism of DPC-Exos in HF regeneration during wound healing are still unclear. In this study, the effect of DPC-Exos on fibroblasts in wound healing was explored for the first time. We found that DPC-Exos could promote the proliferation and migration of fibroblasts, and more importantly, enhance the hair-inducing capacity of fibroblasts. The fibroblasts treated with DPC-Exos could induce HF neogenesis in nude mice when combined with neonatal mice epidermal cells. In addition, the results of in vivo experiments showed that DPC-Exos could accelerate wound re-epithelialization, and promote HF regeneration. The expression levels of Wnt pathway transcription factor β-catenin and Lef1 were elevated in fibroblasts and the dermis of skin wounds after DPC-Exos treatment. Taken together, this study proved that DPC-Exos could promote HF regeneration during wound healing by activating fibroblasts and the Wnt/β-catenin signaling pathway, suggesting that DPC-Exos might be a promising therapeutic strategy for skin wound regenerative healing.
A Permutaion Importance Based feature selection method and Deep Learning Model to Detect Phishing Websites
Authors: Zaimi Rania , Hafidi Mohamed , Mahnane Lamia
Published: February 2024

Phishing attacks pose a significant and escalating threat to cybersecurity in recent times. This deceptive scam aims to trick naive users, luring them into visiting harmful websites and sharing sensitive information, including credentials, credit card numbers, and passwords. Consequently, cybercriminals exploit this data for their own gain. As the sophistication and maliciousness of phishing continue to evolve, researchers are earnestly developing multiple anti-phishing solutions in the literature. Among these solutions, those based on deep learning models have gained substantial attention in recent years. This study proposes an intelligent, deep-learning-based mechanism to detect phishing URLs. The proposed system is based on the permutation importance method (PIM) to select the most relevant URL features, and the Smote-Tomek link method to solve the problem of an unbalanced dataset. In addition, four DL models—CNN, LSTM, and two hybrid models (CNN-LSTM and LSTM-CNN)—are tested to identify the more suitable detection model for the phishing field. The experimental results demonstrate the successful functioning of the proposed phishing detection mechanism. It is observed that the proposed mechanism achieved an accuracy ranging from 93.36% to 96.43% without feature selection and data balance across two variants of datasets and different DL classifiers. It also achieved an accuracy ranging from 94.12% to 96.88% with feature selection and data balance. Finally, our phishing detection mechanism is implemented as web application to enhance its usability for web users.
Evaluating the Effect of Bias Correction Methods in Regional Climate Model Outputs for Rainfall- Runoff Modeling In Katar Watershed Ethiopia
Authors: Yersaw Babur Tesfaye , Chane Mulusew Bezabih
Published: February 2024

Identifying a suitable bias correction method is important to provide reliable inputs for evaluation of climate change impact. This study evaluates five precipitation bias correction methods (BCM) and three temperature BCM for Katar catchment. The BCMs were evaluated using several statistical measures such as, bias (PBIAS), root mean squared error (RMSE), mean absolute error (MAE), coefficient of variation (CV), personal correlation coefficient (R2), and relative volume error (RVE). The annual rainfall bias of the models varies between 7.5% and 257.93% suggesting overestimation. The result showed that the methods used to correct bias improve the RCM-simulated rainfall and temperature to a certain degree in terms of frequency and time series based statics. The raw RCM- simulated precipitation overestimates the wet month observed precipitation in all RCM- outputs. All bias correction methods reduce the overestimation of the raw RCM-simulated precipitation in all models. From the result ECDF performed better than the other bias correction methods based on the corrected annual, monthly, and daily rainfall comparison followed by PT, DM, LOCI, and LS. The temperature bias-correction method's effect was insignificant. The performance of raw RCM precipitation and temperature for stream flow was very poor with a value of NSE (0.2), R2 (0.37), RVE (25.69), and MAE (8.17) but the performance was improved by the application of BCM. The ECDF combined with the DM shows the best performance in stream flow simulation with NSE (0.63), R2 (0.64), RVE (-0.43), and MAE (4.78).
Uranium Electrodeposition at Boron-Doped Diamond Electrodes
Authors: Acevedo-González Alexis J. , Peña-Duarte Armando , Lagle Richard M , Drabo Mebougna , Jones Andrew C. , Cabrera Carlos R
Published: February 2024

The uranium electrodeposition process on a boron-doped diamond electrode (BDD) surface at varying potentials as a means of environmental uranium remediation has been studied. The chronoamperometry technique was employed for the electrodeposition process, applying potentials ranging from − 0.60V to -2.00V vs. the reversible hydrogen electrode (RHE). A 2mM uranyl acetate dihydrate (UO2(C2H3O2)2·2H2O) solution in 0.1M KClO4 served as a model uranyl ion (UO22+) source. Analysis using scanning electron microscopy, energy-dispersive X-ray fluorescence spectroscopy, and atomic force microscopy (AFM) confirmed the presence of uranium and the formation of a thin layer on the electrode surface. Roughness measurements obtained through AFM analysis at different applied potentials vs. RHE were compared before and after uranium electrodeposition at BDD electrodes. Additionally, the identification of various uranium oxides resulting from the electrodeposition procedures was conducted using X-ray photoelectron spectroscopy (XPS) and Raman spectroscopy. These analyses revealed the presence of UO2, UO3, and U3O8 on the BDD electrode surface due to the electrochemical deposition process, with a notable proportion of U3O8 observed. Ultimately, the optimal potential for efficient U6+ remediation from aqueous media and the formation of a uniform thin layer conducive to nuclear technology development was determined to be -1.75V vs. RHE.
Governance and the Relationship between Corruption and FDI in Africa: A Threshold regression analysis
Authors: Lakha Bianca , Oyenubi Adeola , Fadiran David , Naik Nimisha
Published: February 2024

Research on the institutional environment, corruption, and FDI highlights an important facilitating relationship between these factors. Competing views on the effect of corruption on FDI vis-à-vis the grabbing hand vs. the helping hand hypotheses has been examined in the literature. It has also been suggested that both hypotheses can co-exist under the assumption that the FDI-corruption relationship depends on the level of institutions. This study revisits this relationship for 34 African countries over the 2005 to 2019 period using the dynamic panel threshold model, which allows for an endogenous threshold variable. In the past, studies that have examined this relationship using a threshold regression approach are either not based exclusively on African countries (where the implication of this relationship is more salient) or use a threshold regression that assumes exogeneity of the threshold variable. This study examines the facilitating nature of various governance measures – political stability, government effectiveness, rule of law and regulatory quality – on the corruption-FDI relationship. The results indicate significant threshold effects. It also shows that while the grabbing hand hypothesis is consistent with the data irrespective of the institutional proxy used, the helping hand hypothesis is sensitive to the choice of governance. These results agree with the strand of literature in support of a weak helping hand hypothesis.
JEL classification: C33, E22, F21, K42, P37
Topological alterations in white matter anatomical networks in cervical dystonia
Authors: Zhang Jiana , Luo Yuhan , Zhong Linchang , Liu Huiming , Yang Zhengkun , Weng Ai , Zhang Yue , Zhang Weixi , Yan Zhicong , Xu Jinping , Liu Gang , Ou Zilin , Peng Kangqiang
Published: February 2024

Background
Accumulating neuroimaging evidence indicates that patients with cervical dystonia (CD) have changes in the cortico-subcortical white matter (WM) bundle. However, whether these patients’ WM structural networks undergo reorganization remains largely unclear. We aimed to investigate topological changes in large-scale WM structural networks in patients with CD compared to healthy controls (HCs), and explore the network changes associated with clinical manifestations.
Methods
Diffusion tensor imaging (DTI) was conducted in 30 patients with CD and 30 HCs, and WM network construction was based on the BNA-246 atlas and deterministic tractography. Based on the graph theoretical analysis, global and local topological properties were calculated and compared between patients with CD and HCs. In addition, the relationship between abnormal topological properties and clinical characteristics was analyzed.
Results
Compared with HCs, patients with CD showed changes in network segregation and resilience, characterized by increased local efficiency and assortativity, respectively. In addition, a significant decrease of network strength was also found in CD patients relative to HCs. No significant correlations were found between altered network properties and clinical characteristics in patients with CD.
Conclusion
Our findings show that extensive reorganization of the large-scale WM structural network exists in patients with CD. However, this reorganization is attributed to dystonia-specific abnormalities or hyperkinetic movements that need further identification.
Is it safe to operate without frozen section biopsy in short segment Hirschsprung’s disease, an overview of 60 cases
Authors: Ademaj Isber , Kurshumliu Fisnik , Hoxha Ilir , Hyseni Nexhmi , Gjonbalaj Naser
Published: February 2024

Background - Advancment in surgical menagement in a single-stage procedure made intraoperative frozen section biopsy critical for determinin of level of resection to avoid the potential risk of leaving a retained aganglionic segment. However, in most low-income countries due to te lack of this facility, surgeon’s intraoperative judgement is used for the determination of resection level.
Objective - This study aims to evaluate the accuracy of determining the level of bowel resection in short segment HSCR based on macroscopic changes by identifying transition zone as sudden increase in the width typically marked proximal to aganglionated with progressive dilatation in normoganglionated segemnt.
Material and methods -Intraoperative macroscopic evaluation was assessed with postoperative microscopic findings to determine whether the Surgeons intraoperative judgement was accurate in determining the level of bowel resection in 60 cases operated from short segment HSCR. In addition, Pearson's correlation coefficient was used to determine if the sensitivity and specificity of both methods were significantly correlated.
Results - Microscopic results showed that the level of resection based on macroscopic evaluation was performed in normally ganglionated segment. Findings confirmed perfect concordance between microscopic and macroscopic evaluation in predicting the level of resection (Kappa=1). The sensitivity and specificity of macroscopic and microscopic examinations showed perfect positive correlation also (Pearson's correlation coefficient r = 1.0).
Conclusion - Macroscopic intraoperative assessment by experienced surgeon is highly accurate method in deteminin the level of bowel resection in short segment HSCR.
Determinants of small business tax compliance behaviour: evidence from Zimbabwean small businesses
Authors: Duve Munyaradzi , Schutte Daniel P , Kour Manjit
Published: February 2024

Many developing countries have implemented tax regulations for small enterprises and the simplification of tax systems in recent times. Tax compliance attitudes within this sector vary significantly due to the high cost to comply and the technical nature of tax law. Many different factors influence presumptive tax compliance and previous research did not necessarily identify the determinants of this phenomenon. Two hundred and nineteen small business owners/managers participated in the study. The validation of the measurement model and the structural model was performed using the Partial-Least Squares Structural Equation Model. The study evaluated the impact of tax morale, corruption and taxpayer/tax office relationships on presumptive tax compliance in the Zimbabwean context. It was found that corruption significantly influences small business operators' compliance levels under a presumptive tax system. Significant differences were found in small business owners and managers who differed in their perceptions of their relationships with the tax office. The results of this study would assist tax authorities in understanding small businesses' perceptions when reviewing the current presumptive tax systems.
VISTA: Vision Improvement via Split and Reconstruct Deep Neural Network for Fundus Image Quality Assessment
Authors: musluh Saif Khalid
Published: February 2024

Widespread eye conditions such as cataracts, diabetic retinopathy, and glaucoma impact people worldwide. Ophthalmology uses fundus photography for diagnosing these retinal disorders, but fundus images are prone to image quality challenges. Accurate diagnosis hinges on high-quality fundus images. Therefore, there is a need for image quality assessment methods to evaluate fundus images before diagnosis. Consequently, this paper introduces a deep-learning model tailored for fundus images that supports large images. Our division method centres on preserving the original image’s high-resolution features while maintaining low computing and high accuracy. The proposed approach encompasses two fundamental components: an autoencoder model for input image reconstruction and image classification to classify the image quality based on the latent features extracted by the autoencoder, all performed at the original image size, without alteration, before reassembly for decoding networks. Through post-hoc interpretability methods, we verified that our model focuses on key elements of fundus image quality. Additionally, an intrinsic interpretability module has been designed into the network that allows decomposing class scores into underlying concepts quality such as brightness or presence of anatomical structures. Experimental results in our model with EyeQ, a fundus image dataset with three categories (Good, Usable, and Rejected) demonstrate that our approach produces competitive outcomes compared to other deep learning-based methods with an overall Accuracy of 0.91, a precision of 0.88, a recall of 0.89, and an impressive F1-score of 0.89. The code is publicly
available at https://github.com/saifalkhaldiurv/VISTA_Image - Quality - Assessment.
Risk factors for recurrent thrombosis and comparison of DOACs vs VKA in selected thrombotic antiphospholipid syndrome
Authors: Guillaume LEMESLE , Guillaume BOUZILLE , Nicolas BELHOMME , Chloé ROUSSEAU , Erwan DUMONTET , Isabelle GOUIN , Alain LESCOAT , Alice BALLERIE
Published: February 2024

Introduction :
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the presence of autoantibodies (anti-cardiolipin, anti-β2GP1, and lupus anticoagulant) associated with arterial, venous, or microcirculatory thrombotic events and/or obstetrical events (miscarriages, fetal death, and preterm deliveries). The treatment of thrombotic events is based on long-term anticoagulant therapy with vitamin K antagonist (VKA). Direct oral anticoagulants (DOACs) are not recommended by international guidelines as first-line therapy because of an increased risk of recurrent thrombosis observed in several randomized trials. This study aimed to report a cohort of patients with thrombotic antiphospholipid syndrome (TAPS) to identify risk factors associated with recurrent thrombosis and to identify differences between patients treated with VKA and patients treated with DOACs.
Materials and methods :
We collected data from 207 patients with TAPS from an initial population of 655 patients identified by automated screening software.
Results :
This retrospective longitudinal analysis based on real-life data confirmed previously identified risk factors for thrombotic recurrence, such as the absence of antithrombotic treatment following the initial thrombotic event, treatment with antiplatelet treatment alone following the initial thrombotic event. No difference between patients treated with VKA (n=123) or DOACs (n=50) were observed on the risk of recurrent thrombosis. Patients with VKA versus DOACs had more frequently triple APL positivity, presence of lupus anticoagulant and absence of an initial venous thrombotic event.
Conclusions :
This results suggest a potential use of DOACs in the treatment of TAPS for patients with a primary VTE event and a single APL positivity profile, although its retrospective design prevents firm recommendations.
Mesenchymal stem cell-derived extracellular vesicles accelerate diabetic wound healing by inhibiting NET-induced ferroptosis of endothelial cells
Authors: Yang Shuofei , Lu Wei , Li Xiaoyang , Wang Zheyu , Zhao Changbo , Li Qi , Zhang Lei
Published: February 2024

The impaired healing of chronic wounds poses a significant challenge in diabetes. Hindrance to angiogenesis is considered a key driver of delayed wound healing in diabetes. Neutrophil extracellular traps (NETs) have been identified as a detrimental factor impeding wound healing in diabetes, but the precise mechanisms are not fully elucidated. Traditional approaches for wound healing exhibit constrained therapeutic effectiveness due to prolonged recovery periods and increased susceptibility to infections. Extracellular vesicles derived from mesenchymal stem cells (MSC-EVs) have been identified as agents capable of facilitating tissue regeneration and enhancing wound repair. In this study, NET-induced ferroptosis of endothelial cells (ECs) was verified as a crucial factor contributing to angiogenesis hindrance in diabetic wound healing in both clinical samples and animal models. NETs regulated the ferroptosis of ECs by suppressing the PI3K/AKT pathway. Furthermore, MSC-EVs transferred functional mitochondria to neutrophils within the wound tissue, triggered mitochondrial fusion, and subsequently restored mitochondrial function to reduce NET formation. Treatments targeting the inhibition of NET formation and EC ferroptosis or activation of the PI3K/AKT pathway remarkably improved wound healing. This study reveals a novel NET-related mechanism underlying diabetic wound healing and proposes a promising strategy for expediting the recovery of diabetic wounds.
Visibilización de la escritura de mujeres en Colombia. El caso de Reptil en el tiempo, un análisis a partir de la poética de María Helena Uribe de Estrada
Authors: Ospina Malaver Nathaly
Published: February 2024

El presente trabajo tiene como propósito fundamental indagar sobre la poética de María Helena Uribe de Estrada, a partir de su novela Reptil en el tiempo (1986). Esta obra, que nos impone de entrada la posibilidad de explorar una autora poco trabajada y leída, da cuenta de una escritura femenina innovadora en la que su protagonista plasma la necesidad de escribir y ser leída. Para ello, revisamos cómo lo estético y lo temático establecen rupturas respecto al papel de la mujer-escritora.
Borges lector y escritor: a propósito del leer y del escribir
Authors: Zambrano Sánchez Oscar Marino
Published: February 2024

El texto pretende abordar una aproximación al conocimiento de algunas facetas que permiten construir lo que tal vez pudiera ser la identidad de Borges: Borges lector y escritor, ganando un escalón más en la comprensión de lo que quizá sea su “verdadera” dimensión humana. Las preguntas orientadoras son: ¿Cómo se piensa a sí mismo?, ¿cómo se vive él mismo? En lo que sigue, el esfuerzo está encaminado a intentar responder a estas preguntas.
Algunos elementos convergentes en la formación posgradual en maestrías en educación en México y Colombia durante las décadas del 80 y del 90
Authors: Garzon Orfa
Published: February 2024

Desde las relaciones entre currículo e investigación, se abordan dos vertientes que permiten reconocer los trayectos convergentes en la formación posgradual en las Maestrías en Educación en las décadas del 80` y del 90´ en México y Colombia. La primera vertiente está centrada en el contexto y la segunda en las convergencias de las decisiones desde lo curricular e investigativo de los programas de Maestría en Educación
Sexualidad en personas transgénero: revisión de literatura
Authors: Angarita Ariadna María , Cortés Gómez Yeimy Yurany , Vela Tarazona María Fernanda
Published: February 2024

La sexualidad es un aspecto fundamental en la vida de los seres humanos, el cual se asocia íntimamente con el género. En el presente texto, se realizó la búsqueda y revisión bibliográfica de una muestra final de sesenta artículos sobre el fenómeno de la sexualidad, relacionados con la población transgénero, debido a que esta comunidad ha sido poco estudiada en diferentes ámbitos. Por consiguiente, el objetivo principal fue obtener información relevante de investigaciones con personas transgénero en lo referente a la sexualidad, teniendo en cuenta las diversas experiencias de la transición y el significado de género, placer sexual, sexo biológico, reproducción e identidad sexual. Asimismo, cabe destacar que una gran cantidad de personas transgénero tienen que atravesar un camino de estigmas y discriminación, a pesar de que existan ciertas políticas que protegen sus derechos.
Naturaleza moral y ética del animal humano. Una mirada desde Dominique Lestel
Authors: Quintero Calvache Juan Carlos
Published: February 2024

Desde los antiguos hasta los modernos, con referencia a los filósofos, el problema de la ética y la moral se ha asumido como un constructo de la razón humana y sólo de la razón, sin tener presente la condición biológica que encarna el propio hombre. A partir del texto de Dominique Lestel “Los orígenes animales de la cultura” (2001), intentaré mostrar que los constructos éticos y morales del comportamiento humano son expresiones auténticas de una especie animal con cierta afinidad genética que se expresan en eventos y situaciones específicas de su mundo social, que el fundamento del actuar ético y moral no está mediado por razones de orden normativo institucional, y, que la moralidad y eticidad humana es propia de nuestra animalidad y no de un orden culturalmente humano.
Role of Socioeconomic Uncertainty on Foreign Direct Investment (FDI) Inflows and Economic Growth in ASEAN
Authors: Marasanti Andi Tiara Putri , Verico Kiki
Published: February 2024

The interconnectedness begins with active trade and foreign investment flowing to the host country, making the economies in the world integrated into one another. Unfortunately, the rise of interconnectedness has sky-rocketed uncertainty. Economists then build the considered socioeconomic index, namely the World Uncertainty Index (WUI). This research aims to determine whether such an index can affect Foreign Direct Investment (FDI) inwards and economic growth, especially in ASEAN. We use yearly data of FDI inflows, economic growth, and WUI as a proxy for the global level of domestic uncertainty, inflation, and real effective exchange rate from 2015 to 2019 for each ASEAN member state. We estimate a System Generalized Method of Moments (Sys-GMM) to see the dynamic relationship and the short- and long-run effect of the socioeconomic uncertainty proxies with respect to FDI inflows and economic growth. The results show that the uncertainty index with respect to FDI inflows and growth has been negative and significant. Meanwhile, only FDI inflows sensitively respond to socioeconomic uncertainty in the long run, despite the growth for ASEAN member state.
AN ITALIAN TRAVELLER DISCOVERING BOSNIA
Authors: Banjanin Ljiljana
Published: February 2024

The theme of this paper is the image of Bosnia by Luchino Dal Verme (1838- 1911), a politician, diplomat, geographer and traveller, who in 1903 set off from Italy on a journey across the Adriatic Sea and on to Bosnia. He left a testimony of his experience in the text ‘An Excursion to Bosnia’, published in the Nuova Antologia in 1903.

The aim of the paper is to identify odeporic elements in a text of a hybrid nature with elements of geography, history and literature and to show that the perception of this region of the Balkans changed at the beginning of the 20th century. From the wild, primitive and hostile land of the 19th century travellers, the image offered by Luchino Dal Verme changes radically. This affirms the importance of this traveller’s profile, a cultured and informed man. With a considerable cultural background, he observes and accepts the Other and his land, without conditioning.
ABSOLUTE EQUIVALENCE OF PHRASEOLOGISMS WITH THE COMPONENT EYE IN ITALIAN, SPANISH AND SERBIAN
Authors: Vujović Marija N.
Published: February 2024

This paper deals with a contrastive and conceptual analysis of somatic phraseologisms with the component eye in Italian, Spanish and Serbian, with the aim to find absolute cross-linguistic equivalents, i.e. those phraseologisms that will show a perfect symmetry on the semantic, formal and functional level, but also congruence in the concepts they express. A corpus of 102 phraseologisms was excerpted from the relevant general and phraseological dictionaries. The initial hypothesis is that, despite the fact that cases of absolute equivalents are rare, the analysed corpus will offer a significant number of such phraseologisms since somatic phraseology, due to the universality of bodily experience, reveals analogies between languages. The corpus was first subjected to a contrastive analysis in order to identify the cases of absolute equivalents. The corpus was also subjected to conceptual analysis, that aimed at determining the motivational mechanism underlying the phraseologisms, thanks to the postulated conceptual metaphors and metonymies, and then the phraseologisms were classified into semantic fields. The results confirmed the initial hypothesis. The phraseological corpus of the three contrasted languages offers a significant number of absolute translation equivalents among phraseologisms with the component eye. The largest number of absolute equivalents belongs to the semantic fields INSIGHT (6), followed by LOVE and ATTENTION/CAUTION (5). The first case can be explained by the fact that in almost all linguistic and cultural communities, eyes symbolise intellectual perception, and the second, that the semantic field of LOVE does not have precisely defined boundaries and implies different feelings ranging, from liking to lust. In the case of ATTENTION/CAUTION, the eyes, as the most important sense that perceives almost 90% of information serve, among other things, to monitor a situation and keep it under control. Some phraseologisms owe their absolute equivalence to the Bible, classical literature or mythology, and some to polygenesis and calques.
THE OPTATIVE IN THE ALBANIAN LANGUAGE
Authors: Malja Imami Nailja R. , Markovic Andjela M.
Published: February 2024

The verb system of the Albanian language in its present form is quite rich in different tense and modal forms. Some of them are inherited from the oldest stages of the language, others are relatively new internal creations. Although this verb form has been studied by a number of prominent albanologists such as F. Bopp (1854) (Franz Bopp), G. Meyer (1888) (Gustav Meyer), H. Pedersen (1895) (Holger Pedersen), Dh. Kamarda (1864) (Dhimitër Kamarda), Gj. Pekmezi (1908) (Gjergj Pekmez), M. Domi (1961) (Mahir Domi), Sh. Demiraj (1986) (Shaban Demiraj), its origin and development remain unclear and many questions remain open. In this paper, we deal with its historical development, its use, and we will give the opinions of other well-known linguists about this verb form. We will also analyse two books in terms of how much the optative is used in the standard language and how much in the dialect. Based on the analysis of specific examples, we concluded that the optative mood in the Albanian language is more commonly used in old texts, ballads, folktales, and dialects, and it is increasingly less utilised in standard literature, indicating a trend towards reduction, similar to what occurs in other Indo-European languages.
THE FREQUENCY AND USAGE OF OVER-DERIVATIVES IN TEXTS ON COVID-19
Authors: Tomić Božana M. , Šajinović Novaković Jelena V.
Published: February 2024

Being stylistically neutral, prefix over- is used in different functional styles. Here the focus is on its usage in words appearing in written newspaper texts on COVID-19. The main goal of the paper is to examine the overall frequency of overderivatives in this type of text. The idea is to illustrate the most frequent word class of derivatives, show their meanings and to analyse morphological and colligational patterns in which and with which they occur. Derivational prefixes can change either the meaning of the word they are attached to or the word class. Taking into account the frequency and features derived words with this prefix show, we consider that this paper will give a significant contribution to further research on over-words in different types of texts.
BEING BLACK IN AMERICA: THE ANALYSIS OF RUDY FRANCISKO'S POETRY THROUGH THE PRISM OF RACE, DOUBLE IDENTITY AND POSTCOLONIAL CRITICISM
Authors: Lojić Neira R.
Published: February 2024

The poetry of contemporary American-Belizean poet Rudy Francisco carries one new and, we could say, quite personal view on the position of black people in America. The aim of this work is the analysis of Francisco’s poems, which talk about the identity of this minority in the USA and race politics, which greatly affect the status of black people. While referring to the work of the forerunners who paved the way for research in the area of postcolonial criticism and the studies of the identity of black people such as Frantz Fanon, Jacques Lacan, Du Bois and others, this work will display the connection between the selectively chosen Francisco’s poems and the ideas of postcolonialism. During the interpretation of the particular poems, the effect of the BLM (Black Lives Matter) movement, which continues to this day, will be felt significantly. We will also analyse the role of white police officers in the battle for the equality of black people. When all of the above-mentioned research subjects of this paper are taken into account, it is evident that the work of Rudy Francisco gives a certain freshness to the study of the identity of black people.
BOŽIDAR PETRANOVIĆ AND THE EMERGENCE OF PERIODICALS IN SERBIAN IN THE PROVINCE OF DALMATIA
Authors: Jelić Danijela D.
Published: February 2024

Božidar Petranović belongs to a group of prominent actors as regards to the 19th-century Serbian culture in the province of Dalmatia (part of the present-day Croatia). Although his social engagement is versatile (among other things, he was a law attorney, a writer, a literary historian, a translator, a deputy in the parliament, a creator of legal documents, and a historian), one of his most notable contributions would be the establishment and subsequent editing of a journal entitled Srpsko-dalmatinski magazin, the first publication dealing with Serbian literature in Dalmatia, whose influence was felt far beyond the imagined borders. For that reason, this paper is focused on the editorial, cultural, and literary engagement of Božidar Petranović among the Serb population in Dalmatia, especially as regards to the aforementioned journal.
A CRITICAL ANALYSIS OF THE DISCOURSE OF NEWSPAPER ARTICLES IN THE ITALIAN LANGUAGE ON THE (NON)PARTICIPATION OF NOVAK ĐOKOVIĆ IN THE AUSTRALIAN OPEN
Authors: Mitrović Marija M. , Puhar Jelena D.
Published: February 2024

This paper, within the framework of critical discourse analysis, deals with newspaper articles about the (non)participation of Novak Djokovic at the 2022 Australian Open, published in the electronic editions of the Italian daily newspapers Corriere della Sera and La Repubblica in January 2022. The aim of this paper was to, following Van Dijk (1988a), investigate the schematic organisation of the texts from our corpus, as well as to examine which linguistic units are used in those texts to create a positive and negative image of Novak Djokovic. The results of the research show that a very small number of analysed articles fit into Van Dijk's model of organisation of newspaper texts. The results of the linguistic analysis of the texts indicate that, on the one hand, the discourse strategies of nomination and predication are used to highlight Novak's sporting success, and on the other hand, they serve to portray Novak, who did not receive the vaccine against covid 19, as the culprit for not participating in the Australian Open in 2022 and as a person who behaves recklessly and irresponsibly during the coronavirus pandemic.
Bioinformatics-based Identification of Ferroptosis-related Genes and their Diagnostic Value in Gestational Diabetes Mellitus
Authors: Lv Xiaomei , An Yujun
Published: February 2024

Background:

Gestational diabetes mellitus (GDM) is considered a risk factor for
heart metabolic disorder in future mothers and offspring. Ferroptosis is a new type of programmed
cell death, which may participate in the occurrence and development of GDM.

Objective:

This study aims to identify ferroptosis-related genes in GDM by bioinformatics
methods and to explore their clinical diagnostic value.

Methods:

The dataset GSE103552 was analyzed using the Gene Expression Omnibus (GEO)
database to screen for differentially expressed genes (DEGs) in GDM. Gene Ontology (GO) and
Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and proteinprotein
interaction (PPI) network were performed. Gene sets for ferroptosis were retrieved in
MSigDB and GSVA gene set analysis was performed on the database. Finally, logistic regression
was performed to differentiate between GDM patients and controls to screen for diagnostic
markers.

Results:

A total of 179 DEGs were identified in the expression profile of GDM. GO and KEGG
enrichment analysis revealed significant enrichment in the TGF-β, p53 signaling pathway, platelet
activation, glutathione metabolism, sensory perception of taste, and leukocyte and vascular
endothelial cell migration regulation. DEGs (n = 107) associated with the ferroptosis gene set
were screened by GSVA analysis. The screened DEGs for disease and DEGs for ferroptosis
scores were intersected and 35 intersected genes were identified. PPI identified two key genes
associated with GDM as CCNB2 and CDK1. Wilcox-test showed low expression of CCNB2
and CDK1 in GDM. The area under the ROC curve (AUC) of the CCNB2 and CDK1 prognostic
model was 0.822.

Conclusion:

The genes associated with ferroptosis in GDM were CCNB2 and CDK1, which
can be used as valid indicators for the diagnosis of GDM.