bluuebunny/crossref_metadata_2025 huggingface dataset:
JUEGOS INFANTILES PARA ESTIMULAR EL APRENDIZAJE EN NIÑOS DE EDUCACIÓN INICIAL, QUERECOTILLO-SULLANA
Authors: García Infante María Pilar , Tavara Estrada Yngrid Yaqueline , Pacherrez La Chira Rosita Haydee
Published: September 2023

La investigación se interesó por indagar sobre un problema recurrente en niños de educación inicial: el deficiente nivel de logro en nociones de motricidad, desarrollo sensorial y reflexivo. Por eso, se planteó una investigación cuantitativa aplicada, de diseño pre experimental con preprueba y posprueba en un solo grupo, con el objetivo de determinar si la integración de juegos infantiles estimula el aprendizaje en una muestra de 20 niños de 5 años de la Institución Educativa Inicial n° 526 de Querecotillo (Sullana), a quienes se les administró una prueba guiada diseñada en base a figuras para medir su nivel de aprendizaje receptivo y por descubrimiento. En conclusión, se determinó que la estructuración y aplicación de juegos basados en bloques lógicos, el uso de pelotas y el cuento Caperucita Roja, favorece significativamente el aprendizaje de los niños, tal como se corroboró al comparar frecuencias y medias de la pre y posprueba
TUTELA JUDICIAL EFECTIVA EN LAS SENTENCIAS DE APORTES PREVISIONALES EN AMAZONAS 2015-2018
Authors: Rafael Vásquez Greysi , Cayllahua Dioses Pilar Mercedes , Auris Evangelista German
Published: September 2023

La investigación abordó el derecho a la Tutela Judicial Efectiva, en la ejecución de los procesos laborales de cobro de Aportes previsionales. El objetivo fue determinar los procesos de cobro de aportes previsionales incoados por las AFPs contra la Dirección Regional de Educación Amazonas entre el 2015 al 2018,. Se realizó una investigación básica, con un diseño no experimental, la población estuvo conformada por los procesos tramitados ante el Juzgado de Paz Letrado de Chachapoyas entre el 2015 al 2018, en un total de 51, de acuerdo con la información proporcionada por la Corte Superior de Justicia de Amazonas, se utilizó la observación como técnica de recolección de datos y de los resultados de la investigación. Se concluye que no se garantizó la Tutela Judicial Efectiva puesto que las sentencias emitidas no han sido ejecutadas por dicha institución del Estado.
FACTORES DETERMINANTES EN LA DESERCIÓN ESCOLAR DURANTE LA COVID-19 SEGÚN PERCEPCIÓN DE PADRES DE FAMILIA, INSTITUCIÓN EDUCATIVA PRIVADA, LIMA 2021
Authors: Carranza Zegarra Fanny Susana
Published: September 2023

En la presente investigación se ha detectado el nivel del factor determinante en la deserción escolar durante la Pandemia COVID-19 según la percepción de los padres de familia en una Institución Educativa. La deserción escolar es un problema recurrente por muchos motivos. Sin embargo, en estos últimos años se ha evidenciado una mayor tendencia debido a la pandemia COVID-19. Por ello, con este estudio de nivel descriptivo comparativo y con un diseño no experimental, descriptivo comparativo; con una muestra conformada por 94 padres de familia; aplicando la técnica de la encuesta con un instrumento basado en un cuestionario de 15 ítems. Obteniendo los resultados donde se evidencia que para el grupo de sexo masculino el nivel es alto en un 15%, nivel regular en un 70% y nivel bajo en un 15%; del mismo modo para los de sexo femenino en un nivel alto un 19%, de nivel regular en un 81% y nivel bajo en un 0%. Llegando a la conclusión que el nivel de recursos tecnológicos en general es de nivel regular en mayor proporción y tanto en los 2 grupos de varones como mujeres tienen una percepción de nivel regular en los recursos tecnológicos en mayor proporción.
El ilícito penal de corrupción y su incidencia en el régimen público
Authors: Rivero Santoyo Samuel
Published: September 2023

El delito de peculado y su incidencia en la administración pública, donde los funcionarios y servidores públicos cometen actos delictivos, peculado directo como recursos propios a consecuencia de la actividad local o autonómica continuada. En la cual la recaudación, o Foncomun, perturba así el normal funcionamiento de la tesorería y la administración del Estado. El objetivo fue analizar el ilícito penal de corrupción y su incidencia en el régimen público. Asimismo, se tuvo en cuenta en este estudio la metodología hermenéutica, que ha permitido la búsqueda reflexiva de datos de calidad científica de fuentes bibliográficas desde el enfoque cualitativo. En la cual se concluye que los funcionarios o servidores públicas sean una amenaza para la administración estatal y el incumplimiento de los deberes especiales que les imponen por razón de su cargo, derivados del marco legal, donde la naturaleza de revalorización de la compra y la malversación de fondos por parte de funcionarios públicos municipales es la contratación por revalorización; por lo cual los funcionarios o servidores públicos están facultados para utilizar fondos tanto de sus propios fondos como del presupuesto para pagar los servicios y en consecuencia, compras con cuentas falsas para beneficio personal puede ser considerado un delito de corrupción bajo la modalidad de peculado, según el artículo 387 del Código Penal Peruano.
La evaluación docente en Chile: necesidades de formación de los actores implicados
Authors: Almonacid Barria Karla Lorena , Navarro Levill Andres Esteban , Ruete Zuñiga David Alfredo
Published: September 2023

El presente estudio cualitativo está relacionado con el proceso de evaluación docente en Chile, que se inició en 2003 y se estableció en 2016 bajo la Ley 20903. En consecuencia, el propósito de este estudio fue conocer las necesidades profesionales de los docentes en la elaboración de carpetas docentes. Para ello, se realizaron entrevistas estructuradas a 415 docentes de primaria y secundaria. En este sentido, el 58% de los participantes indicaron la necesidad de un mayor desarrollo profesional. Con base en las necesidades de desarrollo profesional identificadas, se realizaron cinco grupos de enfoque, cada uno con 6 a 8 maestros. A través de estos grupos de discusión, los hallazgos revelan necesidades profesionales derivadas de la elaboración de carpetas que abarcan aspectos como la planificación de cursos, la atención a la diversidad, la evaluación, la reflexión y la colaboración.
Dificultades de lenguaje para apropiarse del sistema de escritura en el III Ciclo de Educación Básica Regular
Authors: Villanueva Soplin Florentina
Published: September 2023

El estudio parte de una realidad problemática, la escritura en los estudiantes del III ciclo de educación básica regular, para ello se tiene en cuenta el estado del arte, que permite afianzar el problema de la investigación, asimismo compartir información, generar una demanda de conocimientos, ofreciendo diferentes posibilidades de la comprensión del problema. En ese sentido, la escritura descubre el sentido profundo de nuestros actos, de nuestras actitudes y de nuestros sentimientos, basados en el lenguaje que exterioriza nuestros sentimientos, emociones, la crítica, a través de la escritura. El objetivo de la investigación fue Determinar las características de las dificultades del lenguaje para apropiarse del sistema de la escritura en los estudiantes en el III ciclo de Educación Básica Regular. En la metodología se tuvo en cuenta el enfoque cualitativo, asimismo el método descriptivo, acompañado del método bibliográfico y hermenéutico para analizar las fuentes secundarias como argumentos de las variables de estudio, llegando a la conclusión que el lenguaje como una herramienta de la comunicación consiste en emplear convenciones formales del lenguaje, tales como las competencias gramaticales, y lingüísticas.
Elaboración de un libro digital interactivo con producciones literarias del proyecto de lectoescritura PARQUELEER
Authors: Guarnizo Motta Ermes , Caicedo Clavijo Sonia Elizabeth , Quinto Mosquera Jhina
Published: September 2023

La siguiente investigación presenta los resultados de la elaboración de un libro digital interactivo que recopila las ediciones literarias de PARQUELEER, empleando las herramientas TIC con los estudiantes del grado noveno de la Institución Educativa Marco Fidel Suárez del municipio de Milán, Caquetá. El trabajo se desarrolló en el campo de elaboración de Recursos Educativos Digitales (RED), desde la investigación cualitativa con un modelo basado en diseño, abordando tres categorías: producción literaria, modelo de evaluación LORI-AD y herramientas TIC. La recolección de la información se realizó mediante búsqueda, exploración y lectura de documentación recopilada en archivos físicos y digitales medianamente organizados, análisis documental, material audiovisual e implementación de instrumentos de recolección de datos. El libro digital interactivo fue desarrollado en la herramienta Exelearning y evaluado con la herramienta LORI-AD  Adame (2015), recolectando 26 formularios de evaluación aplicados en un grupo focal conformado por 42,3% de estudiantes de grado noveno, 38,5% de docentes y 23,1% de profesionales no licenciados en ejercicio docente. La evaluación de los nueve criterios que conforman la herramienta LORI-AD permitió obtener un puntaje total de 82, clasificándose como un recurso BUENO, con posibilidad de ajustes. Se concluye que tener un libro digital interactivo con producciones literarias de PARQUELEER es interesante, agradable y coherente con las metas propuestas, destacando la participación de estudiantes, padres de familia y docentes que ven este trabajo como una oportunidad para fortalecer herramientas pedagógicas y didácticas que apoyen el ejercicio educativo desde cualquier área del conocimiento, visibilizando acciones y avances en proyectos escolares.
ESTRATEGIA DEL APRENDIZAJE BASADO EN PROBLEMAS (ABP) PARA FORTALECER LAS CAPACIDADES COGNITIVAS EN LOS ESTUDIANTES DE UNA UNIVERSIDAD NACIONAL – CHACHAPOYAS.
Authors: Rojas Paico Jessica Noemi , Ñañez Campos Oscar , Zuñiga Quiñones César
Published: September 2023

El presente estudio denominado estrategia del aprendizaje basado en problemas (ABP) para fortalecer las capacidades cognitivas en los estudiantes de una universidad nacional – Chachapoyas. Se gestó una investigación de naturaleza cualitativa cuyo diseño de investigación transaccional o de corte transversal en la recolección datos en un solo momento, en un tiempo único. Su propósito es describir variables y explicar su influencia en un momento dado; utilizando métodos y técnicas en el proceso de la investigación; con una población de 35 estudiantes, con una muestra de selección no probabilística de 35 estudiantes, en la cual se aplicó los instrumentos del cuestionario y el instrumento de la rúbrica. Llegando a la conclusión que si existe influencia entre estrategia del aprendizaje basado en problemas (ABP) y las capacidades cognitivas en los estudiantes puesto que están totalmente de acuerdo el 71%; y 10 estudiantes consideran que el ABP ha influenciado en su aprendizaje.
Visualizing the Outcome of Matches of a Tournament in a Single Display
Authors: Bhattacharjee Dibyojyoti , Saikia Hemanta
Published: September 2023

Visualization has by now become an integral part of modern-day research. With the advances in computation technology data display is extensively used in different fields of research, making data more explanatory and insightful. Graphical displays have also become very popular in sports, especially for television audiences. But with the improvement in technology, different stakeholders associated with sports have made use of data for measuring the performance of players, framing strategy, etc. Statistical graphics and tools of data visualization have played a significant role in sports analytics. In this paper, the authors try to develop a semi-graphical display that can be utilized to visualize the schedule of the tournament along with the outcome of all the matches. To explain how the display works, data from the ICC Twenty20 Cricket World Cup of 2022 was used. In the said tournament-12 teams participated. Though the cricket tournament is taken as an example to produce the display the presentation can be extended to other sports as well where more teams participate. Some potential areas where the display can be used are also discussed.
Pelatihan Google Spreadsheet Untuk Mempermudah Pekerjaan Bagi PKK Kelurahan Paledang
Authors: Wati Risa , Fauzi Ahmad , Nawawi Imam , Rachmi Hilda , Azizah Silvy Nur
Published: September 2023

Di Kecamatan Bogor Tengah, Kota Bogor terdapat Kelurahan Paledang. Salah satu kegiatan kelompok Ibu-ibu PKK di Kelurahan Paledang adalah melakukan sensus terhadap jenis pekerjaan seluruh warga Kelurahan Paledang. Pengolahan data masih dilakukan secara manual yang memakan waktu lama dan kurang efisien. Oleh karena itu, diperlukan kegiatan Pengabdian kepada Masyarakat. Kegiatan ini bertujuan untuk membantu kelompok Ibu-ibu PKK di Kelurahan Paledang dalam pengolahan data menggunakan Microsoft Excel melalui Google Spreadsheet melalui media handphone, sehingga pengolahan data dapat dilakukan oleh siapa saja, kapan saja, dan di mana saja, sambil tetap menjaga kerahasiaan informasi. Pengabdian masyarakat dilaksanakan dengan cara penyampaian materi secara langsung dan memberikan pelatihan dalam penggunaan Google Spreadsheet
Classification of Apple Types Using Principal Component Analysis and K-Nearest Neighbor
Authors: Hasan Moh. Arie
Published: September 2023

Apple is a fruit that is quite popular in Indonesia and is widely consumed by people. This fruit has various types of shapes and colors. Types of apples can be distinguished by their color, size, and shape, but it is still difficult for ordinary people to type apples that are more similar in color and size, such as the examples of Braeburn and Crimson Snow apples. This gave rise to the idea of researching image processing to classify the types of apples. This is to help determine the differences between the two types of apples. The classification process of apples is done by testing the image of an apple based on existing training data. The research method consisted of preprocessing image segmentation with morphological operations and feature extraction into Principal Component Analysis (PCA). The classification algorithm used is a K-Nearest Neighbor (KNN). Using adequate training data will further improve the classification of types of apples. The final results of this study amounted to 91,67%.
Comparative Analysis of Restock Needs Bottled Water Using K-Nearest Neighbor (K-NN), Support Vector Machine (SVM), and the Naïve Bayes Algorithm
Authors: Pratiwi Ruri Faujana Dinda , Sumarlinda Sri , Nastiti Faulinda Ely
Published: September 2023

Restocking goods is essential for bottled drinking water to ensure smooth production and maintain a stable product supply. This research aims to compare the K-Nearest Neighbor, Support Vector Machine, and the Naïve Bayes algorithm to predict the need to restock bottled water. The data set for training and training data is taken from Adimaru's Agent. The comparative analysis with three algorithms gives the results of the prediction analysis for the accuracy value of K-NN is 88.20%, SVM is 84.51%, and Naïve Bayes is 66.20%. The AUC values of the three result algorithms include Good Classification. The comparison of the K-NN and SVM with T-Test algorithms get obtained the best performance with an alpha value is 0.102. From this accuracy value, the classification method of the K-Nearest Neighbor algorithm has the best predictive model results for restocking needs of bottled water goods.
Interior Design of Samin Community Culture Museum With Neo Vernacular Concept in Blora
Authors: Fadhilla Novrizka Dzia , Rahmanu Widayat
Published: September 2023

Samin Community Tourism Village in Blora is located in the middle of the forest and also far from the hustle and bustle of the city, as well as a place to store cultural heritage from the Samin culture is also very less a problem experienced by the Samin Community Tourism Village. Not many people in general know about the Samin people who live in the Klopo Dhuwur Village area, Blora. Therefore, to introduce and preserve the culture of the Samin people, a place that can maintain the collections of the Samin people's heritage is needed. Samin Community Cultural Museum was designed with a neo vernacular concept in which this concept combines modern and traditional concepts in its interior. This concept was chosen to design a museum that is interactive but does not leave the culture of the surrounding area. The neo vernacular concept will be implemented in interior elements and furniture.
Analysis of Design Elements on Secret Magic Control Agency Movie Poster
Authors: Eli suryani  , Bedjo Riyanto  , Sarwono
Published: September 2023

In a film industry, advertising media is needed to promote or introduce films to be shown. One of the advertisements that is often used in cinema is posters. Posters are closely related to visual communication design, with visuals depicted can convey the important point of a film. Movie posters contain information and have design elements, namely visual elements and verbal elements contained in the design of Secret Magic Control Agency animated film posters. In the animated film, Secret Magic Control Agency is a family comedy film made in England and Russia based on popular fairy tales by brothers Gimm who are reliable storytellers who write many famous legendary fairy tales. The purpose of this study is to describe the elements of poster design and poster design styles used in Secret Magic Control Agency movie posters. The research method used is a qualitative descriptive method with data collection techniques, literature studies, and observations on Secret Magic Control Agency animated film posters. The design style of this poster is 3D, fun and secret agent adventure where the illustrations of the poster related to the magical world are depicted like real life objects that are colorful and contain fantasy which is very suitable for children. The Secret Magic Control Agency animated movie poster is made in accordance with the principles of layout, namely sequence and asymmetrical balance.
Indonesian Batik Study of Go Tik Swan at 1950-1990 Period in Surakarta
Authors: GRAFITA AFRIK , Rudianto M.
Published: September 2023

Batik is very closely related to the Majapahit Empire and Islamic kingdoms in Java in the past. The development of batik incessantly took place during the Mataram kingdom in 1600-1700. During this time, batik spread throughout Java, where it was used for ceremonial purposes and attire for royalty, and the craftsmen of the palace artists created various kinds of batik motifs. The treasury of batik designs developed from a variety of aesthetic orientations, in Central Java's palaces, designs were often inspired by ritual. The spread of batik culture to the birth of coastal batik, its emergence is a new period in the world of batik. This period deserves to be called modern batik, the form of coastal batik has developed very widely with various cultural influences brought by immigrants. One of the pioneers in the world of batik in Surakarta City is Go Tik Swan Panembahan Hardjoanagoro, he is the creator of the birth of Indonesian Batik which was inspired by President Soekarno's orders. Indonesian batik is a sophisticated blend of batik elements in the archipelago, namely classic batik and coastal batik in the design of the motifs and the use of colors. Go Tik Swan makes the concept of semi-delinquent as the basis for creating inner masterpieces. Indonesian batik is modern and multi-colored, but does not leave its roots, namely Javanese culture in terms of design motifs, production processes, and their meanings. The aims of this study were to study the rationale for Indonesian Batik based on the concept of semi-deferred by Go Tik Swan, to know the process of creating and realizing Indonesian Batik, and to understand the role of "semi-deferred" in the style of Indonesian Batik by Go Tik Swan.
Locuciones prepositivas en los textos constitucionales de distintos países de habla hispana
Authors: Popek-Bernat Katarzyna
Published: September 2023

En el artículo se propone examinar el uso de una serie de locuciones prepositivas (especificamente el modelo ) en el lenguaje jurídico empleado en diferentes países de habla hispana. El objetivo del trabajo es demostrar que el español jurídico es una lengua de especialidad con numerosos rasgos distintivos marcados diatópicamente. Con este fin se presentarán resultados del estudio de un corpus conformado por textos constitucionales de 20 países hispanohablantes. Con las herramientas de análisis textual de los programas Sketch Engine y WordSmith Tools, se compararán los diversos usos de estas locuciones en distintas constituciones para evidenciar el problema del pluricentrismo del español jurídico. Se verá que estas construcciones, con un grado alto o intermedio de fijación en la lengua general, se utilizan de forma menos estable en un contexto jurídico, presentando frecuentemente variación en su estructura y desviándose de la norma culta. Las conclusiones obtenidas del estudio pueden constituir un valioso punto de partida para formular una descripción sistemática de las modalidades geolectales de la lengua española jurídica con vistas a su aplicación en la práctica y didáctica de la traducción.
La terminología especializada y su contexto científico en la cobertura del terremoto de Amatrice (italiano-español)
Authors: González Vallejo Rubén
Published: September 2023

El periodista representa una fi gura que no solo transmite información científica, en su función mediadora de conciliar el binomio conocimiento-desconocimiento, sino que se hace portavoz de las instituciones ante alertas por riesgo o desastres ambientales. Asimismo, es el contacto directo con gran parte de la sociedad y de su selección de fuentes dependerá no solo el conocimiento general y específico del lector, sino también el grado de relevancia de los actores implicados. Inicialmente, en este estudio se ilustrarán unas breves notas teóricas sobre los aspectos más importantes para la consideración del corpus periodístico utilizado en este trabajo, esto es, la transcendencia del periodismo ambiental y su cobertura informativa, una descripción del actual perfi l del periodista-traductor y su relación con la terminología. Posteriormente, se presentará el corpus final realizado con noticias extraídas de diferentes periódicos italianos y españoles de las primeras 48 horas del terremoto italiano de Amatrice en 2016. Como resultados, se muestra la escasa formación lingüística en los planes de estudio del Grado en Periodismo, la tendencia de los periódicos españoles a usar más terminología científica y se introducen nuevos mecanismos lingüístico-discursivos para tratar la terminología especializada, como la comparación, la descripción, la ejemplifi cación, la amplificación y la causalidad.
Análisis de los factores desmotivadores durante la enseñanza a distancia de emergencia causada por el Covid-19: El caso del español como lengua extranjera en el Instituto Cervantes de El Cairo
Authors: del Carmen Méndez Santos María
Published: September 2023

La pandemia del Covid-19 supuso un reto para las sociedades y los gobiernos que tomaron como respuesta de emergencia el trasladar la educación a una modalidad virtual. Esta medida se realizó de forma improvisada y apresurada dada la urgencia de la situación. Eso conllevó que el proceso de enseñanza-aprendizaje se trasladase a un formato y vía para los que no estaban diseñados, con lo que numerosos desafíos emergieron durante su implementación. Dado este contexto, nuestro objetivo fue investigar y delimitar qué factores provocaron la desmotivación del alumnado con el fin de informar tanto a docentes como a gestores de centro de cómo optimizar la enseñanza en caso de que una situación similar ocurra de nuevo. Para ello, hemos llevado a cabo una investigación cuantitativa por medio de cuestionarios a estudiantes del Instituto Cervantes de El Cairo. El instrumento de tipo mixto (con ítems abiertos y otros en formato de escala de Likert) se ha mostrado fiable y consistente mediante pruebas de fiabilidad (α = 0,92). Los datos se procesaron con los programas SPSS 28.0 y QDA Miner Lite. Los resultados nos ofrecen una serie de componentes desmotivadores. Estos tienen que ver ‒en diferentes grados‒ con cuestiones técnicas, didácticas, afectivas y fi siológicas. En particular, los estudiantes se desmotivan por (1) problemas de conexión; (2) la falta de interacción, de contacto y relación emocional con el profesorado y con los compañeros; (3) ausencia de claridad y de relevancia en las actividades y los contenidos; (4) fallos de comprensión; (5) escasez de atención individualizada y (6) mala gestión del tiempo, entre otros aspectos.
Graph-based methods for Author Name Disambiguation: a survey
Authors: De Bonis Michele , Falchi Fabrizio , Manghi Paolo
Published: September 2023

Scholarly knowledge graphs (SKG) are knowledge graphs representing research-related information, powering discovery and statistics about research impact and trends. Author name disambiguation (AND) is required to produce high-quality SKGs, as a disambiguated set of authors is fundamental to ensure a coherent view of researchers’ activity. Various issues, such as homonymy, scarcity of contextual information, and cardinality of the SKG, make simple name string matching insufficient or computationally complex. Many AND deep learning methods have been developed, and interesting surveys exist in the literature, comparing the approaches in terms of techniques, complexity, performance, etc. However, none of them specifically addresses AND methods in the context of SKGs, where the entity-relationship structure can be exploited. In this paper, we discuss recent graph-based methods for AND, define a framework through which such methods can be confronted, and catalog the most popular datasets and benchmarks used to test such methods. Finally, we outline possible directions for future work on this topic.
M6ATMR: identifying N6-methyladenosine sites through RNA sequence similarity matrix reconstruction guided by Transformer
Authors: Xiang Shuang , Zhang Te , Wu Minghao
Published: September 2023

Numerous studies have focused on the classification of N6-methyladenosine (m6A) modification sites in RNA sequences, treating it as a multi-feature extraction task. In these studies, the incorporation of physicochemical properties of nucleotides has been applied to enhance recognition efficacy. However, the introduction of excessive supplementary information may introduce noise to the RNA sequence features, and the utilization of sequence similarity information remains underexplored. In this research, we present a novel method for RNA m6A modification site recognition called M6ATMR. Our approach relies solely on sequence information, leveraging Transformer to guide the reconstruction of the sequence similarity matrix, thereby enhancing feature representation. Initially, M6ATMR encodes RNA sequences using 3-mers to generate the sequence similarity matrix. Meanwhile, Transformer is applied to extract sequence structure graphs for each RNA sequence. Subsequently, to capture low-dimensional representations of similarity matrices and structure graphs, we introduce a graph self-correlation convolution block. These representations are then fused and reconstructed through the local-global fusion block. Notably, we adopt iteratively updated sequence structure graphs to continuously optimize the similarity matrix, thereby constraining the end-to-end feature extraction process. Finally, we employ the random forest (RF) algorithm for identifying m6A modification sites based on the reconstructed features. Experimental results demonstrate that M6ATMR achieves promising performance by solely utilizing RNA sequences for m6A modification site identification. Our proposed method can be considered an effective complement to existing RNA m6A modification site recognition approaches.
Information acquisition in an all-pay auction contest
Authors:   ,   Pontificia Universidad Católica de Chile. Instituto de Economía, Barrientos Barrientos Agustín Orlando
Published: September 2023

We develop a two-player all-pay auction model where an incumbent competes with an entrant. The incumbent’s valuation is publicly known, whereas the entrant’s valuation is unknown but has a publicly known prior distribution. However, before competing in the all-pay auction, the entrant can acquire additional information about his valuation through a learning experiment. This experiment enables him to learn his valuation perfectly, but we also allow for intermediate levels of information. We find that the entrant maximizes his expected payoff by perfectly learning his valuation. Furthermore, the entrant has a greater willingness to pay for information when competing against an incumbent with a similar ex-ante valuation, and a lesser willingness to pay for information when competing against a stronger or weaker incumbent. Nonetheless, the entrant is less willing to pay for information when he competes with a weaker incumbent than a stronger one. We then test the robustness of these results and find that the entrant’s perfect learning outcome is robust only for certain incumbent valuations.
Bacteriological Analysis of Iyiukwu Stream Water in Uhuagu Awgu L.G.A Enugu State, Nigeria
Authors: Ngozi Ewoh Anthonia , Aneke Chinwe Jacinta , Ezea Ifeanyi Boniface
Published: September 2023

The majority of the population of the Iyiukwu community in the Awgu Municipal Area of ​​Enugu State in Nigeria depends on the Iyiukwu stream for its water supply. Due to the recent dcrease in cases of waterborne diseases, a study was conducted to examine the bacteriological characteristics of the Iyiukwu stream in order to protect public health from waterborne diseases. Five of this water samples taken from both the longitudinal profile and bottom level of the creek were tested for  bacteriological properties using standard methods. Total bacterial counts were determined using the cast plate technique and total bacterial counts. From water samples three genera of bacteria genus Klebsiella Alcaligenes and Salmonella were isolated. Total bacterial counts in water samples ranged from 0 to 32 ×102 CFU/ml. Total bacterial counts in the water samples analyzed ranged from MPN index 0 to 39 for coliforms per 50 ml. It was concluded that not all stream water is suitable for consumption and appropriate measures should be taken to clean and treat stream water on a regular basis before drinking.
Effect of Seaweed Extracts on the Growth, Flower Yield and Quality of Dahlia (Dahlia variabilis) C.V. Aditya Birla
Authors: Badgujar Shivangi , Topno Samir E. , Kerketta Anita
Published: September 2023

An experiment entitled “Effect of seaweed extracts on the growth, flower yield and quality of Dahlia (Dahlia variabilis) c.v. Aditya Birla” was conducted to evaluate the response of dahlia to different growth regulators, Kelp @ 2ml and 4 ml and Biovita @ 2ml and 4 ml. Thirteen different treatment combinations were replicated thrice in a Randomized Completely Block Design. The investigation revealed that Biovita was very effective and recorded maximum days to seed germination, plant height, number of leaves, stem diameter, secondary branch number. Leaf area Significant influence of growth regulators was observed on various vegetative parameters. Flower diameter, flower number, diameter and fresh weight increased Significant influence of growth regulators was observed on various foral parameters. Highest flower numbers per plant and flower yield per ha was recorded treatment T11 (4 ml L-1Biovita, 5 days interval). Treatment T11 recorded higher net realization Rs. 506700 which was followed by treatment cost of cultivation with of Rs.170500.. Furthermore, highest Cost benefit ratio was recorded under treatment T11 (1:2.97).
Laboratory Studies on Chromatographic Profile, Toxicity and Repellent Activity of Custard Apple (Annona squamosa L.) Seed Extract
Authors: M. Ilakkia , Premalatha K.  , Vellaikumar S.  , Shanmugam P. S.  , Harish S.  , Jayarajan Nelson S.
Published: September 2023

Plant extracts have toxic substances that can kill termites and other insect pests. Many plant extracts including Annona squamosa have been identified for their anti-termiticidal activity. This study aims to determine the chemical profile, toxicity, and repellent activities of petroleum ether extract against Odontotermes anamallensis and Microcerotermes fletcheri. The GC-MS/MS findings of petroleum ether extract of Annona showed the presence of 9-octadecenoic acid (Z)- as the predominant compound followed by Octadecanoic acid, n-Hexadecanoic acid, 9-Octadecenoic acid (Z)-, 2,3-dihydroxypropyl ester. The probit analysis revealed LC50 values of 2.38 per cent and 3.06 per cent for O. anamallensis and M. fletcheri, respectively. Petroleum ether extract showed repellency with the repellency percent of 48.33 and 31.67 by O. anamalensis and M. fletcheri respectively.  These findings suggest that Annona seed extract is a viable source of natural insecticides against termites.
Relationship between Attention Deficit Hyperactivity Disorder and Severe Substance use Disorder in Adult Inpatients: A Cross-sectional Study
Authors: Calazans Sigrid Terezinha Campomizzi , Moura Isabel Cristina Gomes , Soares Aleida Nazareth , Pires Nathalia Lima , Costa Glacira , Almeida Aline , Duarte Raíssa , Guimarães Nathalia Sernizon , Souza Alessandra Hubner de
Published: September 2023

Objectives: To evaluate the frequency of Attention Deficit Hyperactivity Disorder (ADHD) in adults  admitted for treatment of severe chemical dependence in the Therapeutic Community Rios de Água Viva in Coronel Fabriciano, Minas Gerais, Brazil.

Method: A cross-sectional study with male subjects aged 18 years or older, compared to age-matched men without chemical dependence on a 1:1 ratio. Data collection was performed by applying a questionnaire with the Fifth Edition of Diagnostic and Statistical Manual of Mental Disorders (DSM-5) of American Psychiatric Association criteria for diagnosis of ADHD, also information on demographic profile, smoking and age of onset of psychoactive chemical substance use.

Results: Most patients have high school education (72.7%), are not married (93.2%) and are smokers (86.4%). From 44 patients with Substance Use Disorder who were screened for ADHD symptoms, 22.7% screened positive for the disorder, while only 2.3% of the control group received this diagnosis (p<0.001). The most used drug was alcohol (100%), followed by cocaine-crack (47%) and in third place cannabis (4.5%).

Conclusion: Higher frequencies of ADHD symptoms were found among severe chemical dependents interned in Therapeutic Community.
Efficacy and Tolerability of Gefapixant for Treatment of Refractory or Unexplained Chronic Cough
Authors: Kum Elena , Patel Matthew , Diab Nermin , Wahab Mustafaa , Zeraatkar Dena , Chu Derek K. , O’Byrne Paul M. , Guyatt Gordon H. , Satia Imran
Published: September 2023

Importance

Gefapixant represents an emerging therapy for patients with refractory or unexplained chronic cough.

Objective

To evaluate the efficacy and tolerability of gefapixant for the treatment of adults with refractory or unexplained chronic cough.

Data Sources

MEDLINE, Embase, Cochrane Central Register of Controlled Trials, and Web of Science from November 2014 to July 2023.

Study Selection

Two reviewers independently screened for parallel and crossover randomized clinical trials (RCTs) that compared, in patients with refractory or unexplained chronic cough, either gefapixant with placebo, or 2 or more doses of gefapixant with or without placebo.

Data Extraction and Synthesis

Two reviewers independently extracted data. A frequentist random-effects dose-response meta-analysis or pairwise meta-analysis was used for each outcome. The GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) approach was used to rate the certainty in whether patients would perceive the effects as important (greater than the minimal important difference [MID]) or small (less than the MID).

Main Outcomes and Measures

Cough frequency (measured using the VitaloJAK cough monitor; MID, 20%), cough severity (measured using the 100-mm visual analog scale [VAS]; higher score is worse; MID, 30 mm), cough-specific quality of life (measured using the Leicester Cough Questionnaire [LCQ]; score range, 3 [maximal impairment] to 21 [no impairment]; MID, 1.3 points), treatment-related adverse events, adverse events leading to discontinuation, and taste-related adverse events.

Results

Nine RCTs including 2980 patients were included in the primary analysis. Compared with placebo, gefapixant (45 mg twice daily) had small effects on awake cough frequency (17.6% reduction [95% CI, 10.6%-24.0%], moderate certainty), cough severity on the 100-mm VAS (mean difference, −6.2 mm [95% CI, −4.1 to −8.4]; high certainty), and cough-specific quality of life on the LCQ (mean difference, 1.0 points [95% CI, 0.7-1.4]; moderate certainty). Compared with placebo, gefapixant (45 mg twice daily) probably caused an important increase in treatment-related adverse events (32 more per 100 patients [95% CI, 13-64 more], moderate certainty) and taste-related adverse events (32 more per 100 patients [95% CI, 22-46 more], high certainty). High-certainty evidence suggests that gefapixant (15 mg twice daily) had small effects on taste-related adverse events (6 more per 100 patients [95% CI, 5-8 more]).

Conclusions and Relevance

Compared with placebo, gefapixant (45 mg orally twice daily) led to modest improvements in cough frequency, cough severity, and cough-specific quality of life but increased taste-related adverse events.
Automated Opt-Out vs Opt-In Patient Outreach Strategies for Breast Cancer Screening
Authors: Marcotte Leah M. , Deeds Stefanie , Wheat Chelle , Gunnink Eric , Gray Kristen , Rojas Jorge , Finch Carolyn , Nelson Karin , Reddy Ashok
Published: September 2023

Importance

Optimal strategies for population-based outreach for breast cancer screening remain unknown.

Objective

To evaluate the effect on breast cancer screening of an opt-out automatic mammography referral strategy compared with an opt-in automated telephone message strategy.

Design, Setting, and Participants

This pragmatic randomized clinical trial was conducted from April 2022 to January 2023 at a single Veterans Affairs (VA) medical center. Participants were female veterans aged 45 to 75 years who were eligible for breast cancer screening and enrolled in VA primary care.

Intervention

Veterans were randomized 1:1 to receive either an automatic mammography referral (opt-out arm) or an automated telephone call with an option for mammography referral (opt-in arm).

Main Outcomes and Measures

The primary outcome was completed mammography 100 days after outreach. Secondary outcomes were scheduled or completed mammography by 100 days after outreach and referrals canceled if mammography was not scheduled within 90 days. Both intention-to-treat analyses and a restricted analysis were conducted. The restricted analysis excluded veterans who were unable to be reached by telephone (eg, a nonworking number) or who were found to be ineligible after randomization (eg, medical record documentation of recent mammography).

Results

Of 883 veterans due for mammography (mean [SD] age, 59.13 [8.24] years; 656 [74.3%] had received prior mammography), 442 were randomized to the opt-in group and 441 to the opt-out group. In the intention-to-treat analysis, there was no significant difference in the primary outcome of completed mammography at 100 days between the opt-out and opt-in groups (67 [15.2%] vs 66 [14.9%]; P = .90) or the secondary outcome of completed or scheduled mammography (106 [24.0%] vs 84 [19.0%]; P = .07). A higher number of referrals were canceled in the opt-out group compared with the opt-in group (104 [23.6%] vs 24 [5.4%]; P < .001). The restricted analysis demonstrated similar results except more veterans completed or scheduled mammography within 100 days in the opt-out group compared with the opt-in group (102 of 388 [26.3%] vs 80 of 415 [19.3%]; P = .02).

Conclusions and Relevance

In this randomized clinical trial, an opt-out population-based breast cancer screening outreach approach compared with an opt-in approach did not result in a significant difference in mammography completion but did lead to substantially more canceled mammography referrals, increasing staff burden.

Trial Registration

ClinicalTrials.gov Identifier: NCT05313737
Inpatient EHR User Experience and Hospital EHR Safety Performance
Authors: Classen David C. , Longhurst Christopher A. , Davis Taylor , Milstein Julia Adler , Bates David W.
Published: September 2023

IMPORTANCE

Despite the broad adoption and optimization of electronic health record (EHR) systems across the continuum of care, serious usability and safety problems persist.

OBJECTIVE

To assess whether EHR safety performance is associated with EHR frontline user experience in a national sample of hospitals.

DESIGN, SETTING, AND PARTICIPANTS

This cross-sectional study included all US adult hospitals that used the National Quality Forum Leapfrog Health IT Safety Measure and also used the ARCH Collaborative EHR User experience survey from January 1, 2017, to January 1, 2019. Data analysis was performed from September 2020 to November 2022.

MAIN OUTCOMES AND MEASURES

The primary outcomes were hospital performance on the Leapfrog Health IT Safety measure (overall and 10 subcomponents) and the ARCH collaborative frontline user experience scores (overall and 8 subcomponents). Ordinary least squares models with survey responses clustered by hospital were used to assess associations between the overall measures and their subcomponents.

RESULTS

There were 112 hospitals and 5689 frontline user surveys included in the study. Hospitals scored a mean of 0.673 (range, 0.297-0.973) on the Leapfrog Health IT safety measure; the mean ARCH EHR user experience score was 3.377 (range, 1 [best] to 5 [worst]). The adjusted β coefficient between the overall safety score and overall user experience score was 0.011 (95% CI, 0.006-0.016). The ARCH overall score was also significantly associated with 10 subcategory scores of the Leapfrog Health IT safety score, and the overall Leapfrog score was associated with the 8 subcategory scores of the ARCH user experience score.

CONCLUSIONS AND RELEVANCE

This cross-sectional study found a positive association between frontline user–rated EHR usability and EHR safety performance. This finding suggests that improving EHR usability, which is a current well-known pain point for EHR users, could have direct benefits in terms of improved EHR safety.
CBX4 promotes antitumor immunity by suppressing Pdcd1 expression in T cells
Authors: Ren Liwei , Li Ziyin , Zhou Yu , Zhang Jun , Zhao Ziheng , Wu Zhaofei , Zhao Ye , Ju Yurong , Pang Xuewen , Sun Xiuyuan , Wang Wei , Zhang Yu
Published: September 2023

E3 SUMO‐protein ligase CBX4 (CBX4), a key component of polycomb‐repressive complexes 1 (PRC1), has been reported to regulate a variety of genes implicated in tumor growth, metastasis, and angiogenesis. However, its role in T‐cell‐mediated antitumor immunity remains elusive. To shed light on this issue, we generated mice with T‐cell‐specific deletion of Cbx4. Tumor growth was increased in the knockout mice. Additionally, their tumor‐infiltrating lymphocytes exhibited impaired tumor necrosis factor‐alpha (TNF‐α) and interferon‐gamma (IFN‐γ) production, with an elevated programmed cell death protein 1 (PD‐1) level. In fact, dysregulated Pdcd1 expression was observed in all major subsets of peripheral T cells from the knockout mice, which was accompanied by a functional defect in response to T‐cell receptor (TCR) stimulation. In support of a direct link between CBX4 and PD‐1, Cbx4 overexpression resulted in the downregulation of Pdcd1 expression. Epigenetic analyses indicated that Cbx4 deficiency leads to diminished accumulation of inhibitory histone modifications at conserved region (CR)‐C and CR‐B sites of the Pdcd1 promoter, namely mono‐ubiquitinated histone H2A at lysine 119 (H2AK119ub1) and trimethylated histone H3 at lysine 27 (H3K27me3). Moreover, inhibition of either the E3 ligase activity of polycomb‐repressive complexes 1 (PRC1) or the methyltransferase activity of polycomb‐repressive complexes 2 (PRC2) restores Pdcd1 expression in Cbx4‐transfected cells. Cumulatively, this study reveals a novel function of CBX4 in the regulation of T‐cell function and expands our understanding of the epigenetic control of Pdcd1 expression.
Predicting successful clinical candidates for fiducial‐free lung tumor tracking with a deep learning binary classification model
Authors: Lafrenière Matthieu , Valdes Gilmer , Descovich Martina
Published: September 2023

Objectives

The CyberKnife system is a robotic radiosurgery platform that allows the delivery of lung SBRT treatments using fiducial‐free soft‐tissue tracking. However, not all lung cancer patients are eligible for lung tumor tracking. Tumor size, density, and location impact the ability to successfully detect and track a lung lesion in 2D orthogonal X‐ray images. The standard workflow to identify successful candidates for lung tumor tracking is called Lung Optimized Treatment (LOT) simulation, and involves multiple steps from CT acquisition to the execution of the simulation plan on CyberKnife. The aim of the study is to develop a deep learning classification model to predict which patients can be successfully treated with lung tumor tracking, thus circumventing the LOT simulation process.

Methods

Target tracking is achieved by matching orthogonal X‐ray images with a library of digital radiographs reconstructed from the simulation CT scan (DRRs). We developed a deep learning model to create a binary classification of lung lesions as being trackable or untrackable based on tumor template DRR extracted from the CyberKnife system, and tested five different network architectures. The study included a total of 271 images (230 trackable, 41 untrackable) from 129 patients with one or multiple lung lesions. Eighty percent of the images were used for training, 10% for validation, and the remaining 10% for testing.

Results

For all five convolutional neural networks, the binary classification accuracy reached 100% after training, both in the validation and the test set, without any false classifications.

Conclusions

A deep learning model can distinguish features of trackable and untrackable lesions in DRR images, and can predict successful candidates for fiducial‐free lung tumor tracking.
Evidence‐based consensus guidelines for ALS genetic testing and counseling
Authors: Roggenbuck Jennifer , Eubank Breda H. F. , Wright Joshua , Harms Matthew B. , Kolb Stephen J. ,   the ALS Genetic Testing and Counseling Guidelines Expert Panel
Published: September 2023

Objective

Advances in amyotrophic lateral sclerosis (ALS) gene discovery, ongoing gene therapy trials, and patient demand have driven increased use of ALS genetic testing. Despite this progress, the offer of genetic testing to persons with ALS is not yet “standard of care.” Our primary goal is to develop clinical ALS genetic counseling and testing guidelines to improve and standardize genetic counseling and testing practice among neurologists, genetic counselors or any provider caring for persons with ALS.

Methods

Core clinical questions were identified and a rapid review performed according to Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA‐P) 2015 method. Guideline recommendations were drafted and the strength of evidence for each recommendation was assessed by combining two systems: the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) System and the Evaluation of Genomic Applications in Practice and Prevention (EGAPP). A modified Delphi approach was used to reach consensus among a group of content experts for each guideline statement.

Results

A total of 35 guideline statements were developed. In summary, all persons with ALS should be offered single‐step genetic testing, consisting of a C9orf72 assay, along with sequencing of SOD1, FUS, and TARDBP, at a minimum. The key education and genetic risk assessments that should be provided before and after testing are delineated. Specific guidance regarding testing methods and reporting for C9orf72 and other genes is provided for commercial laboratories.

Interpretation

These evidence‐based, consensus guidelines will support all stakeholders in the ALS community in navigating benefits and challenges of genetic testing.