Unraveling the Complexity of Peyronie's Disease: A Comprehensive Exploration
Authors:   Departamento de Cirugía, Hospital General Regional #1 Vicente Guerrero del Instituto Mexicano del Seguro Social, Acapulco de Juárez, Guerrero, MéxicoDepartamento de Cirugía, Hospital General Regional #1 Vicente Guerrero del Instituto Mexicano del Seguro Social, Acapulco de Juárez, Guerrero, México, Romero Arturo Rojas , Pastrana Rosas José Manuel ,   Departamento de Cirugía, Hospital General Regional #1 Vicente Guerrero del Instituto Mexicano del Seguro Social, Acapulco de Juárez, Guerrero, México, Martinez Maya Gabriela ,   Departamento de Cirugía, Hospital General Regional #1 Vicente Guerrero del Instituto Mexicano del Seguro Social, Acapulco de Juárez, Guerrero, México, López Jiménez Alejandra ,   Departamento de Cirugía, Hospital General Regional #1 Vicente Guerrero del Instituto Mexicano del Seguro Social, Acapulco de Juárez, Guerrero, México, Rios Hernández Dania Ivone ,   Hospital General de Sub Zona No.3 con medicina familiar, Chilpancingo de los bravo, Guerrero - Departamento de urgencias médico quirúrgicas, García Ledezma Arnold ,   Hospital General Regional no.1 Instituto Mexicano del Seguro Social. Tijuana, México.
Published: December 2023

Peyronie's disease (PD) stands as a distinctive pathology within the realm of urology, presenting a multifaceted clinical panorama characterized by the development of fibrous plaques in the tunica albuginea of the penis. Named after the 18th-century French surgeon François Gigot de la Peyronie, this disorder engenders penile deformities, pain, and psychological distress, underscoring the need for a nuanced understanding and comprehensive management approach. This article endeavors to provide an exhaustive exploration of PD, delving into its intricate etiology, pathophysiological underpinnings, clinical manifestations, and the far-reaching implications on psychosocial well-being. The disease's genesis intertwines genetic predispositions, microtrauma during sexual activity, and inflammatory responses, culminating in dysregulated wound healing processes marked by the excessive deposition of collagen. From a clinical standpoint, PD transcends beyond its physical manifestations, adversely impacting patients' mental and emotional states. The altered penile morphology and compromised sexual function pose not only physical challenges but also unravel a complex tapestry of psychological consequences. As such, this article scrutinizes the dual facets of PD, advocating for a holistic approach that addresses both the physical and psychosocial dimensions of the disease. Diagnostic modalities, ranging from clinical evaluation to imaging techniques, form a pivotal aspect of our discourse, providing clinicians with a comprehensive armamentarium for accurate and timely diagnosis. Moreover, an exhaustive review of treatment modalities, encompassing conservative measures, pharmacotherapy, and surgical interventions, aims to distill evidence-based insights guiding therapeutic decision-making. This comprehensive analysis seeks to contribute substantively to the existing body of knowledge, fostering a deeper understanding of PD within the medical community. By amalgamating clinical insights with emerging research trends, this article endeavors to illuminate the path toward refined diagnostic strategies and novel therapeutic interventions, ultimately striving for improved patient outcomes and an elevated standard of care in the management of Peyronie's disease.