bluuebunny/crossref_metadata_2025 huggingface dataset:
Radioecological modelling of I-131 activity dynamics in milk in the central part of Mazovia based on the materials of the "Warsaw" scenario of the IAEA EMRAS project: reconstruction, verification, reliability assessments
Authors:   A. Tsyb Medical Radiological Research Centre – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation (A. Tsyb MRRC), Vlasov O.K. , Zvonova I.A. ,   P. Ramzaev Research Institute of Radiation Hygiene, Shchukina N.V. ,   A. Tsyb Medical Radiological Research Centre – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation (A. Tsyb MRRC)
Published: June 2024

The work was aimed to the study the Cs-137 and I-131 transport dynamics along the trophic chain, from the atmosphere to soil, vegetation, dairy cattle, milk, and the human body. This was done with the use of the radioecological simulation model based on instrumental data from the "Warsaw" scenario of the International Atomic Energy Agency's (IAEA) EMRAS project, which were collected after the Chernobyl nuclear accident. The created simulated radioecological model was used for reconstruction of the I-131 radioactivity in dairy cattle milk in the Warsaw and Ostroleka areas located in the central part of Mazovia, where the cattle dairy milk radiometry was performed in April-May 1986. The aim of the study was to verify the radioecological model, to assess the reliability and uncertainty of the milk block of the computed model. It was found that the successive account of discrepancies between computed and reconstructed instrumental data of I-131 radioactivity dynamics in green fodder on farms in Mazovia areas and the shortage of clean fodder stocks harvest lead to a successive improvement of the agreement between computed and instrumental data of 131I activity in the dairy milk. For all variants of accounting correction the ratio of computed data to instrumental data with recalculated I-131 activities in the atmosphere of the Ostroleka Area is on average 2.5-3 times closer to their ideal value of 1 than in calculations with instrumental data for a cloud. The prognostic properties of the computational model at the stage of reconstruction of the specific 131I activity in milk, estimated as the ratio of computed data to instrumental data, can be estimated as 1.05+/-2.0; the values of these ratios for correction of thyroid radiation doses to the population due to the contaminated milk consumption are estimated as 1.3+/-2.5.
Therapeutic efficacy of the radiopharmaceutical [Lu-177]Lu-PSMA I&T.Preclinical study
Authors:   N.N. Blokhin National Medical Research Center of Oncology, Klementyeva O.E. , Lunev A.S. ,   State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Petrosova K.A. ,   State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Larenkov A.A. ,   State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
Published: June 2024

The appearance of radiopharmaceuticals based on prostate-specific membrane antigen (PSMA) ligands labeled with beta- or alpha-emitting radionuclides led to a breakthrough on the development of targeted therapy for metastatic castration-resistant prostate cancer. For the completeness of the preclinical evaluation of therapeutic radiopharmaceuticals based on PSMA, the study of their effectiveness should be supplemented by an assessment of absorbed doses of internal radiation in experimental tumor foci. The objectives of this study were: 1) Examine the dose-effect relationship to assess the therapeutic efficacy of [Lu-177]Lu-PSMA I&T with activities comparable to those of humans; 2) Assessing the expected absorbed dose levels created in 22RV1 xenografts after the therapeutic effects have been introduced, with the potential for both minimal and maximum radiopharmaceutical accumulation. The studies were conducted on male nu/nu mice with subcutaneous 22RV1 xenografts. The dynamic of accumulation was examined after 2.2 MBq of a radiopharmaceutical was introduced. The main findings were obtained when [Lu-177]Lu-PSMA was introduced at 9.2 MBq (EDmin) and 36.6 MBq (EDmax). A statistically significant dose-dependent inhibition of xenograft growth was found compared with the control. The expected absorbed doses for EDmin in xenografts were between 2.7 Gy for minimal accumulation and 3.9 Gy for maximum accumulation. For EDmax in a similar scenario, this range was 10.7 to 15.5 Gy. The results support the preclinical assessment's informationality in determining the range of doses absorbed in tumor foci that cause the observed therapeutic effects.
2-5G electromagnetic field biological effect by oxidative stress investigation on animals: exposure and aftereffects
Authors:   Izmerov Research Institute of Occupational Health, Perov S.Yu. , Lifanova R.Z. ,   Izmerov Research Institute of Occupational Health
Published: June 2024

The fifth generation (5G) cellular networks development with operation various previous cellular standards indicates a change of electromagnetic background by new sources, and has a human health risk factor. The purpose of the research was to evaluate the electromagnetic field biological effects of monthly multi-frequency electromagnetic field exposure from 2-5G cellular communication systems on some indicators of oxidative stress in the blood of rats and the aftereffect state. The first group of animals exposed by electromagnetic field from 2-4G base stations (central frequencies 1.8; 2.1 and 2.6 GHz), second – 5G with central frequencies 3.5; 28 and 37 GHz. The pro-oxidant and antioxidant components concentrations (diene conjugates, ketodienes) and catalase in blood rats were investigate. Results showed the possibility of pro-oxidant and antioxidant components concentrations imbalance which is a consequence of the oxidation processes activation and an increase body’s adaptive mechanisms, in particular, antioxidant protection. The electromagnetic field biological effect of 5G NR/IMT-2020 exposed is unstable, as opposed to the consequences of 2-4G electromagnetic field exposure.
Radiation situation in the Beshtau mountain area
Authors:   Sergeev Institute of Environmental Geoscience RAS, Miklyaev P.S. , Petrova T.B. ,   Lomonosov Moscow State University, Klimshin A.V. ,   LLC “RPC “Rezolventa”, Marennyy A.M. ,   Research and Technical Center of Radiation-Chemical Safety and Hygiene FMBA of Russia, Tekeev R.A. ,   Center of Hygiene and Epidemiology N 101 FMBA of Russia, Finkovskaya N.S. ,   Center of Hygiene and Epidemiology N 101 FMBA of Russia, Shchitov D.V. ,   Pyatigorsk Institute (branch) of North Caucasus Federal University, Sidyakin P.A. ,   Pyatigorsk Institute (branch) of North Caucasus Federal University, Murzabekov M.A. ,   Pyatigorsk Institute (branch) of North Caucasus Federal University, Tsebro D.N. ,   Pyatigorsk Institute (branch) of North Caucasus Federal University
Published: June 2024

The article presents the outcomes of the dead uranium mine inspection and its impact on the current radiation situation in the Beshtau area, as well as radiation doses to the people using the area as a recreation land. The Beshtau mounting uranium mine was in use from 1940s to 1990s. Several stages of the site remediation were conducted since the 1990s. For these purposes gamma dose rates, density of radon flux from ground surface and its products concentration in the atmospheric air, the content of natural radionuclides in the ground and groundwater were estimated. According to the measurements data it is seen that the area around the main mine facilities located in the southwestern and southern parts of the Beshtau mounting, is the mostly susceptible to radioactive contamination. The water from the springs in this area is not suitable for drinking because the levels of uranium and radon in the water exceed the control safe limits. According to radiation dose estimates in the considered area, it becomes evident that the radiation risk in the area depends mainly on the presence of the gas flows from the tunnel, radiation risk can be higher if the gas flow is not fully extinguished. The tunnels mouths in the study area are not completely extinguished, and the mine air is periodically blown out of them. Due to the current situation, the levels of radon and gamma radiation around the adit mouths exceed the permitted safe limits. If people stay in this area for 4 hours, they can receive radiation dose above 1.0 millisievert (mSv), that exceeds the recommended safe limit. In this regard, it would be advisable to implement measures to prevent or reduce the time people spend in the areas where the former tunnels mouths are located.
A Technology-Aided Program to Help People with Profound Intellectual and Multiple Disabilities Access Preferred Stimulation and Exercise Motor Responses and Visual Orientation
Authors: Lancioni Giulio E. , Alberti Gloria , Filippini Chiara , Singh Nirbhay N. , O'Reilly Mark F. , Sigafoos Jeff
Published: June 2024

People with profound intellectual and multiple disabilities (PIMD) are generally isolated, with a high risk of reduced stimulation input and physical inactivity. One of the strategies available to mitigate this situation relies on using technology-aided programs delivering stimulation contingent on people’s basic responses/activation. The two studies reported here were intended to extend the evidence available in this area. Specifically, Study I assessed whether a technology-aided program, which enabled participants to obtain preferred stimulation by touching an illuminated square (response target) changing position on a touch screen, would effectively increase their responding and, consequently, their stimulation input. Study II served as (a) a replication of Study I and (b) a means to assess whether responding in relation to a target changing position would increase the participants’ visual orientation/attention compared to responding in relation to a static target. Seven participants were included, three in Study I and four in Study II. Each study was conducted using a single-case research methodology. The results of both studies showed that the participants increased their responding and, thus, their stimulation input using the technology-aided programs. The program involving a response target changing position required differentiation of the response schemes (probably increasing the level of physical activation) and also tended to improve visual orientation, compared to the program using a fixed response target. Thus, the program involving a changing position of the response target may be considered a preferable tool for helping people with PIMD.
Adoption of Artificial Intelligence–Enabled Robots in Long-Term Care Homes by Health Care Providers: Scoping Review
Authors: Wong Karen Lok Yi , Hung Lillian , Wong Joey , Park Juyoung , Alfares Hadil , Zhao Yong , Mousavinejad Abdolhossein , Soni Albin , Zhao Hui
Published: June 2024

Background

Long-term care (LTC) homes face the challenges of increasing care needs of residents and a shortage of health care providers. Literature suggests that artificial intelligence (AI)–enabled robots may solve such challenges and support person-centered care. There is a dearth of literature exploring the perspectives of health care providers, which are crucial to implementing AI-enabled robots.

Objective

This scoping review aims to explore this scant body of literature to answer two questions: (1) what barriers do health care providers perceive in adopting AI-enabled robots in LTC homes? (2) What strategies can be taken to overcome these barriers to the adoption of AI-enabled robots in LTC homes?

Methods

We are a team consisting of 3 researchers, 2 health care providers, 2 research trainees, and 1 older adult partner with diverse disciplines in nursing, social work, engineering, and medicine. Referring to the Joanna Briggs Institute methodology, our team searched databases (CINAHL, MEDLINE, PsycINFO, Web of Science, ProQuest, and Google Scholar) for peer-reviewed and gray literature, screened the literature, and extracted the data. We analyzed the data as a team. We compared our findings with the Person-Centered Practice Framework and Consolidated Framework for Implementation Research to further our understanding of the findings.

Results

This review includes 33 articles that met the inclusion criteria. We identified three barriers to AI-enabled robot adoption: (1) perceived technical complexity and limitation; (2) negative impact, doubted usefulness, and ethical concerns; and (3) resource limitations. Strategies to mitigate these barriers were also explored: (1) accommodate the various needs of residents and health care providers, (2) increase the understanding of the benefits of using robots, (3) review and overcome the safety issues, and (4) boost interest in the use of robots and provide training.

Conclusions

Previous literature suggested using AI-enabled robots to resolve the challenges of increasing care needs and staff shortages in LTC. Yet, our findings show that health care providers might not use robots because of different considerations. The implication is that the voices of health care providers need to be included in using robots.

International Registered Report Identifier (IRRID)

RR2-doi:10.1136/bmjopen-2023-075278
A Study on the Relationship Between Non-addictive Smartphone Use and Cognition and Brain Function among the Elderly (Preprint)
Authors: Qin Xucong , Wan Zhenyu , Xu Baohua , Lin Hong , Ouyang Fangcheng , Wang Gaohua , Wan Qirong
Published: June 2024

BACKGROUND

The effects of smartphone use on mental health and brain function in adolescents have received much attention, however, the effects on older adults have received little. As more and more older adults begin to use smartphones, it is imperative to explore the effects of non-addictive smartphone use on mental health, cognitive function, and brain function in older adults.

OBJECTIVE

To explore the relationship between non-addictive smartphone use and cognition and brain function among the elderly.

METHODS

We conducted an investigation targeting all older adults aged 60 years and above in a village in China. The participants were divided into two groups according to whether they used smartphones or not, and the participants were randomly selected from both groups for fMRI scanning. The analysis then compared differences in depression, anxiety, insomnia, cognitive function and brain function between the two groups.

RESULTS

Among all 1015 older adults, 641 reported using smartphones while 373 reported never using smartphones. Older adults who use smartphones exhibited better cognitive function compared with those who never use smartphones (Z = 3.806, P < .001), especially in the domains of fluency (Z = 3.025, P = .002) and abstraction (Z = 5.311, P < .001). But there were no significant differences in levels of depression (Z = 0.689, P = .49), anxiety (Z = 0.934, P = .35) and insomnia (Z = 0.340, P = .73). In terms of the MRI findings, a total of 130 participants completed fMRI scanning, including 89 who use smartphones and 41 who never use smartphones, and results showed that older adults who were smartphone users exhibited higher degree centrality values in the left parahippocampal gyrus.

CONCLUSIONS

Here we showed that appropriate use of smartphones can help improve cognitive function in the elderly.
Advancing CBT for panic disorder and agoraphobia by integrating a digital intervention into treatment: A pilot randomized controlled trial (Preprint)
Authors: Atik Ece , Kalde Jan , Stricker Johannes , Schückes Magnus , Neudeck Peter , Pietrowsky Reinhard , Pittig Andre
Published: June 2024

BACKGROUND

Panic disorder and agoraphobia are frequently co-occurring mental disorders affecting millions of people worldwide. Cognitive behavioral therapy (CBT) is the first-line treatment, supported by a wealth of controlled clinical trials. Supportive digital technologies may further enhance its effectiveness.

OBJECTIVE

This pilot randomized controlled trial investigated if patients with panic disorder and/or agoraphobia benefit from blended cognitive behavioral therapy (bCBT), in which standard CBT is combined with an integrated digital application.

METHODS

Participants were randomized into two groups after being diagnosed with panic disorder and/or agoraphobia. The bCBT group received standard CBT along with a digital application (elona therapy) used between sessions (n = 34). The control group received standard CBT treatment alone (n = 22) for 12 weeks. Both groups completed assessments including standardized questionnaires covering symptoms of anxiety, symptoms of depression, quality of life, work and daily functioning, and mental health literacy at baseline (T0), after 6 weeks (T1), and 12 weeks (T2).

RESULTS

Improvements in symptoms of anxiety were descriptively larger for the bCBT group than for the CBT group at 6 weeks (d = -.28). Yet, this difference decreased after 12 weeks (d = -.12) and did not reach statistical significance. bCBT was superior to standard CBT in improving symptoms of depression after 12 weeks (d = -.46 p = .028). In other secondary outcomes, improvements were descriptively larger for bCBT than for CBT, but these differences did not reach statistical significance.

CONCLUSIONS

bCBT supported by elona therapy showed promising results in reducing symptoms of depression in individuals with panic disorder and/or agoraphobia. In contrast, the benefit of the added digital application for reducing symptoms of anxiety did not reach statistical significance. The pattern of results indicated that bCBT might improve outcomes more quickly, until a treatment ceiling is reached. More research using larger randomized controlled trials (RCTs) is needed to consolidate these findings.

CLINICALTRIAL

ISRCTN16328317
Biografías fragmentadas.
Authors: Sanchez Evelyne
Published: June 2024

Para liberarse de las limitaciones del género biográfico y poder incluir a las personas, grupos y momentos de la vida menos documentados, la microhistoria (en particular Simona Cerruti) propone desarrollar una historia encarnada por medio de fragmentos biográficos. En este artículo ponemos en práctica esta propuesta mediante el análisis de fragmentos relativos a la infancia y a las mujeres y hombres del mundo rural durante la Revolución mexicana, con el fin de poner a prueba este enfoque y evaluar cualitativamente el conocimiento que nos permite adquirir.
Study on the Coordination between Investigation and Prosecution of Securities Cases from an Investigative Perspective
Authors: Zhang Chenyang
Published: June 2024

This paper focuses on “Study on the Coordination between Investigation and Prosecution of Securities Cases from an Investigative Perspective”, exploring critical issues in the coordination of investigation and prosecution in securities markets. Through literature review and case analysis, it examines the current research status, challenges, and the pivotal roles of legal, technological, and social factors in optimizing the process. Research methods include case analysis and comparative studies, delving into strategies and outcomes across different contexts. Finally, it summarizes the main findings and outlines future research directions in technological innovation and institutional optimization.
VALUE, HISTORICITY, AND ECONOMIC EPISTEMOLOGY: AN ARCHAEOLOGY OF ECONOMIC SCIENCE, ALAIN HERSCOVICI
Authors: Tsoulfidis Lefteris
Published: June 2024

Value, Historicity, and Economic Epistemology: An Archaeology of Economic Science by Alain Herscovici presents a unique perspective on the History of Economic Thought (het). What distinguishes this book is its in-depth examination of epistemological considerations and their practical implications for key aspects of het. Sheila Dow, in her foreword, echoes the author’s focus on differentiating between methodology —specific to a particular paradigm— and epistemology, which analyzes the succession of paradigms over time. The het is intrinsically linked with epistemology, the central theme of this book, although it occasionally grapples with issues of meta-epistemology. Herscovici meticulously traces the historical evolution of economic thought across epochs, utilizing the concept of “episteme” or the fundamental framework of understanding. The book adeptly discerns shifts and disruptions in epistemology that have influenced the course of economic thought over time. Through this exploration, it sheds light on a range of heterodox perspectives, contrasting them with neoclassical and Hayekian approaches...
CAMBIOS ECONÓMICOS ESTRUCTURALES Y BRECHAS DE GÉNERO EN EL EMPLEO EN MÉXICO, 2003-2018
Authors: Albornoz Mendoza Lilian
Published: June 2024

El objetivo de este trabajo es analizar la influencia de tres tipos de cambios estructurales en la distribución del empleo entre hombres y mujeres en México: la intensidad del empleo, la tecnología y la demanda final; y si los estos cambios han reducido la brecha y la segregación en el empleo por género. El análisis empírico se desarrolla mediante matrices de insumo-producto anuales del periodo 2003-2018. La información proviene de la base de datos KLMS del Sistema de Cuentas Nacionales de México con base en las horas trabajadas torales por género, escolaridad (alta, media y baja) y sector/subsector de actividad económica. Los resultados aportan evidencia de altas brechas por género en el empleo y segregación horizontal durante todo el periodo. Los cambios en la estructura productiva no han contribuido a la disminución de las brechas ni de la segregación en el empleo que afectan a las mujeres.
INFLUENCE OF STRUCTURAL CHANGES ON THE SECTORAL DISTRIBUTION OF MALE AND FEMALE EMPLOYMENT IN MEXICO, 2003-2018
ABSTRACT
The objective of this paper is to analyze the influence of three types of structural changes on the distribution of employment between men and women in Mexico: Changes in employment intensity, technology, and final demand, and whether the changes have reduced the gap and segregation in employment by gender. The empirical analysis is conducted using annual input-output matrices for the period 2003-2018. The information comes from the KLMS database of the National Accounts System of Mexico, based on total hours worked by gender, educational level (high, medium, and low), and economic activity sector/subsector. The results provide evidence of high gender gaps in employment and horizontal segregation throughout the period. Changes in the productive structure have not contributed to the reduction of gaps or segregation in employment that affect women.
ESTADO, ECONOMÍA Y SOCIEDAD EN EL MÉXICO POSREVOLUCIONARIO, LEONARDO LOMELÍ VANEGAS Y RICARDO GAMBOA RAMÍREZ (COORDS.)
Authors: Novelo y Urdanivia Federico
Published: June 2024

El libro objeto de esta recensión, coordinado por Leonardo Lomelí Vanegas y Ricardo Gamboa Ramírez, recoge 15 trabajos distribuidos en tres partes: I.- La construcción del Estado posrevolucionario; II.- La economía mexicana y la política económica en los años de la reconstrucción nacional, y III.- Sociedad y cultura: entre el nacionalismo y el cosmopolitismo. Aquí revisamos la mayor parte de los ensayos...
Antibacterials Effect of Tulsi (Ocimum sanctum) Powder Nanoparticle and its Scientific Evaluation by Employing Modern Scientific Tools
Authors: Sharma Preeti
Published: June 2024

Abstract: In recent years, nanotechnology has facilitated the development of Tulsi-based nanomedicine. This study explored the importance of Tulsi leaves nanopowder in traditional medicine and nanomedicine and its profound impact on the human body. Tulsi, also known as Holy Basil, has been recognized for its diverse therapeutic properties, including anti-inflammatory, antioxidant, and antimicrobial effects. Integrating traditional medicinal knowledge with cutting-edge nanotechnology has opened new avenues for advancing healthcare. Fresh Tulsi leaves were collected and ground using a mortar and pestle to obtain a coarse powder. The coarse powder was further ball milled for 25 hours in an ethanol medium using a high-energy ball mill method. XRD analysis revealed the crystal structure and the nanoparticle's estimated crystallite size was 21 nm. The average particle size was approximately 160 nm, calculated from the FE-SEM micrograph. The elements present in the Tulsi powder were estimated with the help of EDS. The antimicrobial activity of processed nanomedicine has enhanced due increase surface area of Tulsi nanoparticles and had a positive surface charge.
Formulation and Evalaution of Flaxseeds Hair Gel
Authors: Salunke Vaishnavi B.
Published: June 2024

Abstract: The remedies used to improve a person's look are called herbal cosmetics. Herbal hair gel eliminates dandruff and helps manage hair loss because it is made with natural components and herbal extracts. The purpose of this study was to create and assess a herbal hair gel using flax seed and aloe vera for its ability to promote hair development and fight dandruff. Vitamin E found in flax seed (Linum usitatissimum) promotes stronger follicles and better hair development. Aqueous extraction was used to create extracts from flax seed and aloe vera. Five distinct gel compositions with varied concentrations of Aloe vera and flax seed extracts were made and assessed. A number of characteristics, including color, scent, gel texture, clarity, pH, viscosity, spreadability, extrudability, and gelstability tests, strength, homogeneity, and in vitro antifungal activity. Out of the five formulations, F4 exhibited long-term stability without sacrificing its antifungal efficacy. Overall, the study's findings confirm that herbal hair gel made with aloe vera and other ingrediente remedies used to improve a person's look are called herbal cosmetics. Herbal hair gel eliminates dandruff and helps manage hair loss because it is made with natural components and herbal extracts.
Violencia y deseo sexual en Luis Buñuel: estudio de caso de Él (1953) y Ese oscuro objeto del deseo (1977)
Authors: Serrano Álvarez Arturo , Finol Luis
Published: June 2024

La violencia originada por un deseo desmedido es uno de los temas más importantes en la filmografía buñueliana. La hipótesis de este artículo es que Luis Buñuel maneja una concepción platónica-psicoanalítica del deseo como un sentimiento destinado a una constante frustración, en el sentido de que es siempre deseo de lo que no es poseído en el presente. A partir del análisis de las películas Él (1953) y Ese oscuro objeto del deseo (1977) se observa que, a través del manejo de personajes llenos de inseguridades y carencias, la violencia se convierte en moneda de curso diario y elemento característico que atraviesa no solamente los filmes objeto de estudio, sino la extensa obra del realizador aragonés.
NUMERICAL ANALYSIS OF STRESS-STRAIN STATE OF THE STEEL MODULAR BLOCK WITH CORRUGATED WEBS
Authors: Tusnina Olga , Alekseytsev Anatoliy
Published: June 2024

Modular blocks are widely used in industrial and civil engineering both as stand-alone structures and combined into block-modular buildings. Modular block consists of the load bearing frame, wall fencing, roof and floor decking. The modular block, with wall fencing made of corrugated sheet continuously welded to the beams, is a spatial system, with beams and corrugated webs working together. The steel modular block for the gas pumping unit on a gas turbine power plant is considered in the paper. Assessment of the corrugated web thickness effect on the load bearing capacity of the block is performed. Numerical investigation of stress-strain state of the blocks with different thickness of corrugated web is carried out by the finite element method. The values of the ultimate destructive load on the blocks with different thickness of the corrugated web are determined. The values of the allowable load on the block and the criteria for its limitation have been established depending on the stress-strain state of the block and the causes of destruction. For comparison, a calculation was made of a block with walls made of sandwich panels that are not included in the work of the frame. It is determined that ultimate load on the block with corrugated webs is 1,5-6 times greater than on the block with wall sandwich panels.
The Interpretation of the Meaning of al-Qarábah in the Qur'an and Its Contextualization with Contemporary Kinship Models (An Interpretative Approach Using the Maudhu'i Tafsir Method)
Authors: Bakry Nurdin , Sulfanwandi Sulfanwandi , Habibi MZ Muhammad
Published: June 2024

Based on the interpretation in the Qur'an, relatives (al-qurbá) are interpreted flexibly, according to the context of the conversation, both from the side of the mother's and father's relatives. However, traditional interpretations tend to emphasize the paternal family, reflected in the influence of patrilineal Arabic culture. In the contemporary era, the concept of family in anthropology has varied, including maternal or bilateral models. This study analyzes how the meaning of al-qarábah in the Qur'an with the approach of maudhu'i tafsir, tracing its conformity with the contemporary kinship model? The type of qualitative research and interpretive approach is carried out in order to be answered in depth, data collection through library research, so that the data collected is in the form of secondary data obtained from the books of scholarly interpretation. Content analysis is carried out by collecting verses related to the method of tafsir maudhu'i. As a result, the method of tafsir maudhu'i al-qarābah in Islam is divided into three levels: al-qarābah al-qarībah (very close uterine relationship), al-qarābah al-mutawassiṭah (mahram relatives), and al-qarābah al-baʿidah (non-mahram relatives). In the context of the modern family, kinship is understood through the biological dimensions (nasab/DNA), religion (brothers and sisters), and social (neighborly relationships). Fathers and mothers are considered the nucleus of the family in Islam, with mothers having primary responsibility for the upbringing, education, and inheritance of children in the event of a father's death, affirming protection and harmony in Muslim families.
The Alimony Obligation of a Civil Servant and Non-Civil Servant Father towards Children Post-Divorce (The Study on Aceh Syar'iyyah Court Decision Study of 2019)
Authors: Djawas Mursyid , Eriyanti Nahara , Yulia Anita , Fauzan Faisal
Published: June 2024

This research was motivated by two decisions of the Aceh Syar'iyah Court, namely decision Number 75/Pdt.G/2019/MS. Aceh in determining the child's sustenance after divorce, distinguished by the amount that must be given by civil servant and non-civil servant fathers. However, these two decisions are different from the provisions of the Compilation of Islamic Law (KHI), in which the Compilation of Islamic Law (KHI) does not mention the number of child support provisions. This is the focus of this research, in which two research questions were administered to answer the research inquiries First; what is the judge's consideration in determining the obligation of a civil servant and a non-civil servant father? Second; how does the Islamic law determine the obligations of a civil servant and non-civil servant father to children after a divorce from the study of the 2019 Aceh Syar'iyah Court judge’s decision? This is a library research investigating cases on strategies used by judges in solving various cases. The study reveals that the judge’s considerations in determining the level of child maintenance rights are differed between the judge’s decision Number 75/Pdt.G/2019/MS.Aceh and decision Number 70/Pdt.G/2019/MS.Aceh. The study suggests that the judge has different ways of determining the legal decision. The civil servant fathers are entitled to comply by article 8 PP No. 10 of 1983 jo. PP No. 45 of 1990, while the non-civil fathers are referred to the recommendation of the Compilation of Islamic Law (KHI), which is seen from the ability of the father. This is found to have been in compliance with the Islamic law. Therefore, according to the author, the difference in determining the level of income for children after divorce is relevant to Imam Syafi'i's opinion that income has a certain size. The rich father should pay two mud, middle-class fathers pay one and a half mud and the low-income fathers pay one mud.
Single Tau-Shaped Anterolateral Thigh Free Flap on Bimalleolar Defect Acquired by Osteomyelitis in Lower Extremity Trauma: A Case Report
Authors: Lee Seung Jun , Lee Won Jae , Suh Young Chul
Published: June 2024

Soft tissue defects can cause serious issues in traumatic lower extremity injuries when limb salvage is the goal, especially when complicated by osteomyelitis. The distal lower extremities lack redundant soft tissue, necessitating free tissue transfer for complex injury reconstruction. For bimalleolar defects, a chimeric or double flap is an option, but harvesting such flaps can be challenging, and multiple arterial anastomoses risks distal limb ischemia. We present a case of a large bimalleolar defect with associated osteomyelitis covered with a single anterolateral thigh (ALT) free flap. Preoperative mapping identified perforator distribution allowing design of a single tau-shaped flap from the left thigh to minimize morbidity. The defects were covered successfully with no permanent complications. Given the ALT flap’s consistent anatomy, this case could guide future approaches for typical bimalleolar defects, including those with osteomyelitis.
Leukocytoclastic Vasculitis-Induced Lower Leg Ulceration in the Course of Immune Checkpoint Inhibitor Therapy for Advanced Malignant Melanoma: A Case Report
Authors: Seo Dongkyung , Ariga Shin , Ishikawa Kosuke , Miura Takahiro , Moku Rika , Funayama Emi , Yamamoto Yuhei , Maeda Taku
Published: June 2024

Immune checkpoint inhibitors (ICIs) have expanded therapeutic options for advanced malignancies, offering new hope for conditions once deemed untreatable. However, the advent of ICIs has introduced a spectrum of immune-related adverse events (irAEs), including leukocytoclastic vasculitis (LCV), a rare but significant complication. This case report describes development of LCV after treatment with nivolumab and ipilimumab in a 70-year-old man with malignant melanoma, highlighting the diagnostic and management challenges of such irAEs. Despite extensive investigation, conventional pathology failed to identify the immune complexes typically associated with LCV. The clinical presentation, alongside a detailed medical history and the exclusion of infections, medications, and autoimmune diseases, was crucial in establishing a diagnosis. Ulcer resolution following discontinuation of ICI therapy and initiation of steroids further support the conclusion that LCV was an irAE in this patient. This case underscores the need for vigilant monitoring for irAEs for the variable onset after ICI therapy and the importance of thorough history-taking to guide diagnosis and treatment. With ICIs becoming increasingly prevalent in oncology, the incidence of ICI-induced ulcers like LCV is expected to rise, necessitating heightened awareness and multidisciplinary approaches to patient care.
Deciphering the Role of Non-Coding RNAs as Regulators in the Wound Healing Process
Authors: Shojaeian Ali
Published: June 2024

Various factors can influence the complex process of wound healing. Non-coding RNAs (ncRNAs), which include long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), as well as microRNAs (miRNAs), contribute critically to the regulation of wound healing mechanisms. Specific miRNAs regulate fibroblast proliferation, migration, and extracellular matrix production, while others influence keratinocyte migration and re-epithelialization. Some miRNAs also modulate the inflammatory response and regulate angiogenesis during wound healing. The emerging significance of circRNAs in regulating fibroblast and keratinocyte functions during wound healing are also to be noted, as are the significant roles lncRNAs play in influencing various aspects of wound healing. This review underscores the pivotal roles played by ncRNAs in orchestrating the intricate processes involved in wound healing, providing insights into potential therapeutic targets and strategies for enhancing wound healing outcomes.
Poliposis gástrica en la poliposis adenomatosa familiar: a propósito de un caso. Un enfoque para el endoscopista
Authors: Padilla Ruiz Maykel Alain , Ariza Cotes Gustavo
Published: June 2024

La poliposis adenomatosa familiar (PAF) es un síndrome hereditario autosómico dominante. Aunque la principal manifestación de esta enfermedad es la presencia de numerosos adenomas de colon, también ocurre afectación del tracto gastrointestinal superior. Se presenta un reporte de una paciente joven con una poliposis gástrica (más de 100 pólipos). Se realiza una breve revisión actualizada del tema enfocada en los hallazgos endoscópicos, así como sugerencias actualizadas en el manejo y seguimiento de los pólipos gástricos en la PAF.
EVALUATION OF THE CAPACITY OF APRON FEEDERS USED IN CRUSHING–SCREENING PLANTS BY RESPONSE SURFACE METHODOLOGY AND ARTIFICIAL INTELLIGENCE METHODS
Authors: Köken Ekin
Published: June 2024

In this study, the capacity (Q) of Apron feeders is investigated through response surface methodology (RSM) and some artificial intelligence methods. In this regard, a comprehensive field survey is performed to compile quantitative data on the common working conditions of Apron feeders used in the Turkish Mining Industry (TMI). Based on the collected data, RSM analyses are performed to reveal the factors affecting the Q of Apron feeders. Accordingly, hopper width (B), the height of the material layer conveyed (D), conveyor speed (V), and fill factor (φ) are determined to be the most critical factors for the Q. Several interaction and contour plots are presented to observe the variations in the Q values. Moreover, several predictive models are also introduced to estimate the Q of apron feeders based on artificial intelligence methods such as multivariate adaptive regression spline (MARS), adaptive neuro-fuzzy inference system (ANFIS), and artificial neural networks (ANN). The performance of the established predictive models is assessed based on scatter plots, and it is found that the predictive model based on RSM methodology provides relatively better results than the ones found on soft computing-based predictive models. The presented predictive models can be reliably used to estimate the Q of Apron feeders with high capacity. However, crushing–screening plant designers should be careful when using established predictive models for assessing low-capacity Apron feeders. Based on the findings obtained, the present study demonstrates the applicability of RSM methodology and several artificial intelligence methods for evaluating the Q of Apron feeders.
Refined GEDI Level-2A Database Construction: Focused on Gyeonggi Province, Republic of Korea
Authors: Cho Kyeong-Hun , Lee Seung-Kuk
Published: June 2024

The Global Ecosystem Dynamics Investigation (GEDI), a full-waveform light detection and ranging system, translated the energy into a continuous waveform and recorded the signals chronologically for enabling geometric analysis of the vertical structure of vegetation. The National Aeronautics and Space Administration has used the land, vegetation, and ice sensor (LVIS) airborne laser altimeter system to measure terrain, tree heights, and vegetation carbon stocks in designated areas. The effectiveness of the collected LVIS data has been proven in mapping forest structures and biomass in tropical and temperate systems. Based on the successful achievements of LVIS, the GEDI aimed to establish a global range of forest data needed to analyze and predict the carbon cycle and climate change. The GEDI was launched aboard the SpaceX-16 in 2018 and successfully attached to the International Space Station (ISS) for a 2-year mission, but now extended until March 2023. Since being mounted on the ISS, GEDI measured over 10 billion cloud-free surface observations within the range of 51.6°N to 51.6°S. In this paper, GEDI mission is introduced, and the process of downloading, refining the GEDI level-2A product focused on Gyeonggi Province is outlined.
Feeding programme in captive working elephants of Myanmar
Authors: Mar Khyne U
Published: June 2024

Nutrition is important for a variety of reasons. Animals need the proper nutrition for growth, maintenance, reproduction and for providing energy. For animals used for draught purposes, their nutritional requirements are higher than those of non-working animals. Extensively kept elephants seem to thrive well on the jungle forages, tree fodders, shrubs, herbs and other natural vegetation. However, the nutritional value of forages in natural habitat is closely associated with the preservation of forest, climatic variation and season of the year. This manuscript will focus on the feeding programmes practiced in extensively kept captive working Asian elephants of Myanmar
SGLT2 Inhibitor Dapagliflozin Increases Skeletal Muscle and Brain Fatty Acid Uptake in People With Type 2 Diabetes - A Randomized, Double-Blind, Placebo-Controlled, Positron Emission Tomography Study
Authors: Latva-Rasku Aino , Rebelos Eleni , Tuisku Jouni , Aarnio Richard , Bhowmik Achol , Keskinen Helmi , Laurila Sanna , Lahesmaa-Hatting Minna , Pekkarinen Laura , Isackson Henrik , K. Kirjavainen Anna , Koffert Jukka , Heurling Kerstin , Nummenmaa Lauri , Ferrannini Ele , Oldgren Jonas , Oscarsson Jan , Nuutila Pirjo
Published: June 2024

Objective: The aim of this study was to investigate the impact of the sodium-glucose transporter 2 inhibitor dapagliflozin on tissue fatty acid (FA) uptake in skeletal muscle, the brain, small intestine, and subcutaneous and visceral adipose tissue in people with type 2 diabetes by using positron emission tomography (PET).

Research Design and Methods: In a 6-week randomized, double-blinded, placebo-controlled trial, 53 patients with type 2 diabetes treated with metformin received either dapagliflozin 10 mg or placebo daily. Tissue FA uptake was quantified at baseline and at end-of-treatment with PET and the long-chain fatty acid analogue radiotracer 14(R,S)-[18F]fluoro-6-thia-heptadecanoic acid ([18F]FTHA). Treatment effects were assessed using ANCOVA, and the results are reported as least square means and 95 % CIs for the difference between groups.

Results: 38 patients (dapagliflozin N=21, placebo N=17) completed the study. After 6 weeks, skeletal muscle FA uptake was increased by dapagliflozin vs placebo (1.0 [0.07, 2.0] µmol.100 g-1.min-1, P=.032), whereas the uptake was not significantly changed in the small intestine, visceral and subcutaneous adipose tissue. Dapagliflozin treatment significantly increased whole-brain FA uptake (0.10 [0.02, 0.17] µmol.100 g-1.min-1, P=.01), an effect observed in both gray and white matter regions.

Conclusions: Six weeks of treatment with dapagliflozin increases skeletal muscle and brain fatty acid uptake, partly driven by a rise in FFA availability. This finding is in accordance with previous indirect measurements showing enhanced fatty acid metabolism in response to SGLT2 inhibition, and extends the notion of a shift towards increased fatty acid utilization to muscle and brain.
KACA: Educational Tutorial Video-Based Games to Stimulate Early Childhood Language Skills
Authors: Winardi Diva Winding Seciola Syakhinna , Widiana I Wayan
Published: June 2024

Several findings regarding children's difficulties in reading show that out of a total of 11 children in the class, 8 of them still experience difficulties in initial reading. In addition, researchers also noted that the main reason for these difficulties was due to the slow process of letter recognition in these children. This research aims to develop the "Reading Calendar" (KACA) media, to stimulate children's language skills. This research uses a development approach with the ADDIE model which consists of analysis, design, development, implementation and evaluation. The object of this development research is the learning media educational game tool "Reading Calendar" (KACA) based on educational video tutorials, with a focus on content validity, teacher response, and product effectiveness. The research subjects consisted of ten children from group B, with the children's language abilities as the research object. Data collection methods use observation, rating scales, and questionnaires. Data analysis involves testing validity using the Gregory formula and practicality by teachers using the Aiken formula. The research results show that this learning media is effective in increasing children's interest in learning and providing significant support for teacher performance. This shows that the new reading calendar media based on educational video tutorials is a viable, practical and effective choice in improving the language skills of children in group B. This research has implications for increasing interest and involvement of media in the learning process, so that it can create a better learning experience. interesting.
The Impact of Using Audio Visual Media to Improve Letter Recognition Ability in Kindergarten
Authors: Ayuni Ni Made , Paramita Made Vina Arie
Published: June 2024

Learning currently still uses traditional methods, namely with a whiteboard and markers to introduce letters to children. This study aims to analyze the effect of audio-visual media on the letter recognition skills of children aged 4 to 5 years in kindergarten. This research is included in the type of quantitative experimental research that uses Quasi Experimental Design with Non Equivalent Control Group Design. The population of this study consisted of 30 kindergarten children. Because the population size was less than 100, complete sampling was used to guarantee the sample. Research data collection was carried out using the structural observation method. Meanwhile, data analysis was carried out using descriptive statistical techniques. Analysis of post-test data shows that there is a significant influence of audio-visual media on children's ability to recognize letters. This can be seen from the significant increase in their average performance, which increased from 27.73 before the intervention to 54.93 after the intervention. The results of the hypothesis test further support this observation, because the significance value of 0.002 is lower than the threshold set at 0.05. Therefore, it can be concluded that there is a statistically significant average difference in students' letter recognition skills between the experimental group and the control group. The latest information in this research can have implications for the continued application of audio-visual media to improve the ability to recognize letters in kindergarten children.