bluuebunny/crossref_metadata_2025 huggingface dataset:
Waist Circumference and Its Association With Premenstrual Food Craving: The PHASE Longitudinal Study
Authors: Dang Nhan , Khalil Dina , Sun Jiehuan , Naveed Aamina , Soumare Fatimata , Hamidovic Ajna
Published: April 2022

Visceral adiposity is a significant marker of all-cause mortality. Reproductive age women are at a considerable risk for developing visceral adiposity; however, the associated factors are poorly understood. The proposed study evaluated whether food craving experienced during the premenstrual period is associated with waist circumference. Forty-six women (mean BMI = 24.36) prospectively provided daily ratings of food craving across two-three menstrual cycles (122 cycles total). Their premenstrual rating of food craving was contrasted against food craving in the follicular phase to derive a corrected summary score of the premenstrual food craving increase. Study groups were divided into normal (n = 26) and obese (n = 20) based on the 80 cm waist circumference cutoff signifying an increase in risk. Waist circumference category was significantly associated with premenstrual food cravings [F(1,44) = 5.12, p = 0.028]. Post hoc comparisons using the Tukey HSD test (95% family-wise confidence level) showed that the mean score for the food craving effect size was 0.35 higher for the abdominally obese vs. normal study groups (95% CI: 0.039 to 0.67). The result was statistically significant even following inclusion of BMI in the model, pointing to a particularly dangerous process of central fat accumulation. The present study establishes an association between temporal vulnerability to an increased food-related behavior and a marker of metabolic abnormality risk (i.e., waist circumference), thereby forming a basis for integrating the premenstruum as a viable intervention target for this at-risk sex and age group.
The Prevalence of PTSD in a Forensic Psychiatric Setting: The Impact of Traumatic Lifetime Experiences
Authors: Bianchini Valeria , Paoletti Giovanna , Ortenzi Roberta , Lagrotteria Brunella , Roncone Rita , Cofini Vincenza , Nicolò Giuseppe
Published: April 2022

Background

Several studies have identified traumatic history among forensic patients and its association with criminal behaviors and psychiatric diagnoses. Post-traumatic stress disorder (PTSD) is highly prevalent in forensic settings causing a serious deterioration of the primary psychiatric disorder.

Aims

Our study aims to evaluate the prevalence of PTSD and the role of traumatic experiences and abuse in the development of severe psychiatric disorders in a sample of psychiatric offenders.

Methods

Fifty-three patients admitted in Italian high intensity therapeutic facilities—the Residenze per l'Esecuzione delle Misure di Sicurezza (REMS)—were evaluated with the Trauma Experience Checklist (TEC) and the Millon Clinical Multiaxal Inventory (MCMI-III) to study lifetime traumatic memories and general psychopathology, respectively.

Results

Preliminary findings show that about 41% (N = 22) of psychiatric offenders were affected by PTSD, often not due to a single episode but to multiple lifetime traumas. Therefore, lifetime traumatic experiences and specifically sexual abuse are significant risk factors for the development of a personality disorder, which is present in the 38% (N = 20) of the sample.

Conclusions

The high PTSD prevalence and the strong association found between trauma and abuse with the development of a personality disorder emphasizes the importance of an early evaluation and intervention on traumatic experiences in this difficult population of psychiatric patients; in fact, the treatment of psychiatric offenders is actually vague and devoid of scientific evidence. Our results open up the perspective on the use of known and specific interventions for trauma, such as EMDR and Mindfulness.
Perceived Stress Positively Relates to Insomnia Symptoms: The Moderation of Resilience in Chinese Pregnant Women During COVID-19
Authors: Zou Hongyu , Tao Zhen , Zhou Yongjie , Zhang Zhiguo , Zhang Chunyan , Li Linling , Yang Jiezhi , Wang Yanni , Huang Wei , Wang Jianhong
Published: April 2022

Background

The government’s COVID-19 pandemic response lockdown strategy had a negative psychological and physical impact on individuals, which necessitated special care to pregnant women’s mental health. There has been no large-scale research on the underlying relationship between perceived stress and insomnia symptoms in pregnant Chinese women up to this point. During the COVID-19 pandemic, we wanted to see if there was an association between perceived stress and insomnia symptoms, as well as the moderating impact of resilience for Chinese pregnant women.

Methods

This cross-sectional study examined 2115 pregnant women from central and western China using multi-stage sampling methodologies. A systematic questionnaire was used to collect information on sleep quality, perceived stress, and resilience using the Insomnia Severity Index, Perceptual Stress Scale, and Connor and Davidson Resilience Scale. To assess the moderating influence of resilience, hierarchical regressions were used.

Results

During the COVID-19 pandemic, 18.53% of respondents (N = 2115) reported experiencing sleeplessness. In pregnant women, perceived stress was positively linked with insomnia symptoms (p < 0.001). Furthermore, resilience significantly attenuated the influence of perceived stress on insomnia symptoms in Chinese expectant mother (βinteraction = −0.0126, p < 0.001).

Conclusion

Pregnant women with strong resilience were less influenced by perceived stress than those with poor resilience. The findings of this study might give empirical proof that health care professionals should identify the relevance of reducing perceived stress in pregnant women with poor resilience and provide better treatment and support when necessary.
Mental Health and Wellbeing in Lithuanian Medical Students and Resident Doctors During COVID-19 Pandemic
Authors: Stanyte Agne , Podlipskyte Aurelija , Milasauskiene Egle , Király Orsolya , Demetrovics Zsolt , Ambrasas Laurynas , Burkauskas Julius , Steibliene Vesta
Published: April 2022

Background

The coronavirus disease 2019 (COVID-19) pandemic has had a negative effect on mental health and subjective psychological wellbeing. One of the most affected population is medical students, reporting higher levels of depression, anxiety, sleep difficulties, and overall poorer wellbeing. However, the relationship between depression, anxiety, and sleep difficulties, and subjective psychological wellbeing has not been extensively researched in medical students in the context of COVID-19 pandemic. The aim of this study was to investigate the associations between depression, anxiety, and sleep quality, and subjective psychological wellbeing.

Methods

In total, 524 medical students and resident doctors (78.6% female, mean age 24 ± 3 years old) participated in an online survey between December 2020 and February 2021. Participants completed the WHO—Five Wellbeing Index Questionnaire, the Pittsburgh Sleep Quality Index questionnaire, the Patient Health Questionnaire-9, and the Generalized Anxiety Disorder Assessment-7.

Results

Multivariable logistic regression analysis showed that female participants’ worse subjective psychological wellbeing was associated with sleep difficulties [odds ratio (OR) = 2.39, 95% CI = 1.37–4.18, p = 0.002], higher depression (OR = 6.13, 95% CI = 3.46–10.88, p < 0.001), and anxiety symptoms (OR = 2.95, 95% CI = 1.66–5.22, p < 0.001). In male participants, analysis revealed an association between worse subjective psychological wellbeing and higher depression scores (OR = 9.94, 95% CI = 3.29–30.03, p < 0.001).

Conclusion

Sex differences are an important factor to consider when evaluating subjective psychological wellbeing. Clinicians should be aware of significant contributors, such as sleep patterns anxiety, and depression, to subjective psychological wellbeing.
Case Report: Long-Acting Oral Cariprazine
Authors: Dyrmishi Emanuela , De Pieri Marco , Ferrari Marco , Traber Rafael , Preve Matteo , De Peri Luca , Bolla Emilio
Published: April 2022

Introduction

Cariprazine is a third-generation antipsychotic, approved for the treatment of schizophrenia and bipolar disorder and used off-label for schizoaffective disorder and treatment-resistant depression. Cariprazine is a partial agonist at dopamine receptors D2 and D3 and serotonin receptor 5HT1A and an antagonist at serotonin receptors 5HT2B and 5HT2A. It is metabolized by CYP3A4 in desmetyl-cariprazine and didesmethyl-cariprazine, both active metabolites with a half-life of 1–2 days and 2–3 weeks, respectively.

Case Report

Here we show the cases of 3 outpatients diagnosed with bipolar I disorder (two patients) and schizoaffective disorder (one patients) and characterized by low adherence to treatment, satisfactory cognitive and personal functioning and average disease severity to whom we administered cariprazine as a monotherapy, on a two-times a week schedule (i.e., every 72–96 h). We evaluated response to treatment and disease remission according to conventional definitions, using rating scales BPRS, PANSS and BDI-II. Two-times a week treatment was set either after a disease relapse (one patient), after a sustained remission obtained with daily administration of cariprazine (one patient) or since our first evaluation (one patient). After 4 weeks of treatment all three patients satisfied criteria for response to treatment and remission, a result that was sustained for 8 (in one patients) and 12 months (in other two patients) and still ongoing.

Discussion

Reported results support our hypothesis that long half-lives of cariprazine and its metabolites provide an adequate therapeutic response with a two-times a week administration. In selected patients, cariprazine administered as a “oral long-acting” seems effective in treating acute episodes of illness and in sustaining remission, combining advantages of oral and long-acting injectable antipsychotics concerning therapeutic alliance.
A Systematic Review on the Effects of Different Types of Probiotics in Animal Alzheimer's Disease Studies
Authors: de Rijke Tanja J. , Doting M. H. Edwina , van Hemert Saskia , De Deyn Peter P. , van Munster Barbara C. , Harmsen Hermie J. M. , Sommer Iris E. C.
Published: April 2022

Alzheimer's disease (AD) is a global public health priority as with aging populations, its prevalence is expected to rise even further in the future. The brain and gut are in close communication through immunological, nervous and hormonal routes, and therefore, probiotics are examined as an option to influence AD hallmarks, such as plaques, tangles, and low grade inflammation. This study aimed to provide an overview of the available animal evidence on the effect of different probiotics on gut microbiota composition, short chain fatty acids (SCFAs), inflammatory markers, Amyloid-β (Aβ), and cognitive functioning in AD animal models. A systematic literature search was performed in PubMed, SCOPUS, and APA PsychInfo. Articles were included up to May 2021. Inclusion criteria included a controlled animal study on probiotic supplementation and at least one of the abovementioned outcome variables. Of the eighteen studies, most were conducted in AD male mice models (n = 9). Probiotics of the genera Lactobacillus and Bifidobacterium were used most frequently. Probiotic administration increased species richness and/or bacterial richness in the gut microbiota, increased SCFAs levels, reduced inflammatory markers, and improved cognitive functioning in AD models in multiple studies. The effect of probiotic administration on Aβ remains ambiguous. B. longum (NK46), C. butyricum, and the mixture SLAB51 are the most promising probiotics, as positive improvements were found on almost all outcomes. The results of this animal review underline the potential of probiotic therapy as a treatment option in AD.
Children's Afterschool Culinary Education Improves Eating Behaviors
Authors: Schmidt Susanne , Goros Martin W. , Gelfond Jonathan A. L. , Bowen Katherine , Guttersen Connie , Messbarger-Eguia Anne , Feldmann Suzanne Mead , Ramirez Amelie G.
Published: April 2022

Objective(s)

Culinary education may be one way to improve children's eating behaviors. We formatively evaluated the effect of a hands-on afterschool 12-module, registered dietitian-led culinary education program on healthy eating behaviors in a predominately Hispanic/Latino, low-socioeconomic community.

Methods

Of 234 children participating in the program, 77% completed both pre- and post-assessment surveys (n = 180; mean age 9.8 years; 63.3% female; 74.3% Hispanic/Latino, 88.4% receiving free/reduced lunch). In addition to program satisfaction, we assessed changes in children's self-reported fruit, vegetable, and whole-grain consumption, knowledge, and culinary skills using binary and continuous mixed effects models. We report false discovery rate adjusted p-values and effect sizes.

Results

95.5% of participants reported liking the program. Improved whole grain consumption had a medium effect size, while effect sizes for whole grain servings and vegetable consumption were small, but significant (all p < 0.05). Culinary skills increased between 15.1 to 43.4 percent points (all p < 0.01), with medium to large effect sizes.

Conclusion(s)

The program was well-received by participants. Participants reported improved eating behaviors and culinary skills after program completion. Therefore, this hands-on afterschool culinary education program can help improve healthy eating in a predominantly Hispanic/Latino, low-socioeconomic community.
Whether Social Participation Can Affect the Central Government Public Policy Response to the COVID-19 in China
Authors: Fu Liping , Sun Huajun , Xu Kaibo
Published: April 2022

Objective

The coronavirus disease 2019 (COVID-19) outbreak has threatened the state's governance and public safety. This study investigates whether and how public participation can affect central government policy response to this pandemic in the context of China.

Methods

This study constructs the theoretical framework based on theoretical analysis, and Social Network Analysis is used to analyze data on the public participation, New Media, and the central government response in this pandemic.

Results

Findings show that the Chinese central government does not always adopt top-down elitist governance strategies in risk management. The central government will also adopt the bottom-up governance strategy triggered by public participation. In this process, New Media acts as a catalyst. Specifically, when faced with a public emergency and needs a policy response from the central government, public participation firstly creates “participation” with the authority of the media, forms public opinion, and then the prompt policy response from the central government.

Conclusion

This study confirms that the central government will refer to public participation to decide the policy response. It also shows that the theory of government response applies to both the local government and the central government.
Change in Alcohol Consumption and Binge Drinking in University Students During the Early COVID-19 Pandemic
Authors: Zysset Annina , Volken Thomas , Amendola Simone , von Wyl Agnes , Dratva Julia
Published: April 2022

Objectives

Young adults have been overly affected by the containment measures against COVID-19 and, consequently, worsening in mental health and change in health behavior have been reported. Because the life phase of emerging adulthood is crucial for developing health behaviors, this study aims to examine increase in alcohol consumption, single and multiple binge drinking, and associated factors in students during lockdown and post-lockdown periods.

Methods

A prospective open cohort study design with nine survey time points between April 2020 and June 2021 was conducted. The present study uses pooled data from the first survey T0 (3 April to 14 April) and follow-ups at T1 (30 April to 11 May 2020) and T2 (28 May to 8 June 2020). Students from all faculties of the Zurich University of Applied Sciences (ZHAW) (N = 12'431) were invited. Of the 1,300 students who participated at baseline and in at least one follow-up, 1,278 (98.3%) completed the questionnaires, final net sample size was 947. Generalized Estimating Equations (GEE) models were used to investigate the factors associated with increases in alcohol consumption based on number of occasions/last 30 days; drinks/week, and binge drinking at T0, and respective changes at T1 and T2 (increases, decreases, no change).

Results

Overall, 20% of Swiss university students reported an increased alcohol consumption and 26% engaged in binge drinking. Number of drinks at baseline was associated with a higher probability of increased alcohol consumption, as well as engaging in single and multiple binge drinking events. Higher anxiety scores were associated with a higher probability to increase the alcohol consumption and engaging at least once in binge drinking. Additional factors associated with any binge drinking were male gender, younger age and not living with parents. Higher perceived social support was only associated with engaging in heavy binge drinking.

Conclusions

A substantial number of students developed a more risky health behavior regarding alcohol consumption. It is important to identify at risk students and design target prevention including factors such as age, gender and social norms. Further, health behavior and determinants of health behaviors of students should be carefully monitored during the further course of the pandemic.
Geranylgeranylacetone Ameliorates Beta-Amyloid Toxicity and Extends Lifespan via the Heat Shock Response in Caenorhabditis elegans
Authors: Mossiah Isiah , Perez Sabrina M. , Stanley Taylor R. , Foley Michaela K. , Kim Guisbert Karen S. , Guisbert Eric
Published: April 2022

Activation of a cytoprotective cellular pathway known as the heat shock response (HSR) is a promising strategy for the treatment of Alzheimer’s disease and other neurodegenerative diseases. Geranylgeranylacetone (GGA) is a commonly used anti-ulcer drug in Japan that has been shown to activate the HSR. Here, we establish C. elegans as a model system to investigate the effects of GGA. First, we show that GGA-mediated activation of the HSR is conserved in worms. Then, we show that GGA can ameliorate beta-amyloid toxicity in both muscle and neuronal worm Alzheimer’s disease models. Finally, we find that exposure to GGA is sufficient to extend the lifespan of wild-type worms. Significantly, the beneficial effects of GGA on both beta-amyloid toxicity and lifespan are dependent on HSR activation. Taken together, this research supports further development of GGA as a therapeutic for Alzheimer’s disease, provides evidence that HSR activation is a relevant therapeutic mechanism, and indicates that the beneficial effects of GGA are not limited to disease.
Younger and Older Adults’ Cognitive and Physical Functioning in a Virtual Reality Age Manipulation
Authors: Vahle Nils M. , Tomasik Martin J.
Published: April 2022

Objectives: Age group stereotypes (AGS), especially those targeting old age, affect an individual’s behavior and long-term cognitive and physiological functioning. Conventional paradigms investigating the related mechanisms lack validity and stability. Our novel approach for the activation of self-relevant AGS uses a virtual reality (VR) ageing experience, measuring relevant effects on performance parameters.

Methods: In a between-subjects experimental design, young participants embodied either a younger or older avatar in a 3D virtual environment to capture the effects on physical (Study 1; N = 68) and cognitive performance (Study 2; N = 45). In Study 3 (N = 117), the paradigm was applied to older participants.

Results: For the younger participants, embodying older avatars was associated with declines in memory and physical performance when compared to the younger avatar age group. Furthermore, the manipulations’ main effects were moderated by negative explicit AGS that matched the respective performance domains. For the older participants, we found no significant performance differences in the two domains investigated.

Discussion: The experimental manipulation demonstrated an impact on relevant performance parameters on a motivational and strategic level, especially for strong performance-related AS, but for young participants only. Possible reasons and mechanisms for the differences in younger and older samples’ results are discussed.
Time-Delayed Tandem Microwave Observations of Tropical Deep Convection: Overview of the C2OMODO Mission
Authors: Brogniez Hélène , Roca Rémy , Auguste Franck , Chaboureau Jean-Pierre , Haddad Ziad , Munchak Stephen J. , Li Xiaowen , Bouniol Dominique , Dépée Alexis , Fiolleau Thomas , Kollias Pavlos
Published: April 2022

Convective clouds serve as a primary mechanism for the transfer of thermal energy, moisture, and momentum through the troposphere. Arguably, satellite observations are the only viable way to sample the convective updrafts over the oceans. Here, the potential of temporal derivatives of measurements performed in H2O lines (183GHz and 325 GHz) to infer the deep convective vertical air motions is assessed. High-resolution simulations of tropical convection are combined with radiative transfer models to explore the information content of time-derivative maps (as short as 30 s) of brightness temperatures (dTb/dt). The 183-GHz Tb signal from hydrometeors is used to detect the location of convective cores. The forward simulations suggest that within growing convective cores, the dTb/dt is related to the vertically integrated ice mass flux and that it is sensitive to the temporal evolution of microphysical properties along the life cycle of convection. In addition, the area-integrated dTb/dt, is related to the amount, size, and density of detrained ice, which are controlled by riming and aggregation process rates. These observations, particularly in conjunction with Doppler velocity measurements, can be used to refine these assumptions in ice microphysics parameterizations. Further analyses show that a spectral sampling of the 183 GHz absorbing line can be used to estimate the maximum in-cloud vertical velocity that is reached as well as its altitude with reasonable uncertainties.
Policymakers, Consider Reducing Reliability
Authors: Davidson Brian , Hellegers Petra , George Biju , Malano Hector
Published: April 2022

In this study, the physical and economic impacts of four policy measures (crop diversification, improved watershed development, canal lining and reducing the level of reliability) all designed to improve bulk water supply, are assessed in a case study of the Musi catchment of India. The aim is to compare the impacts these policy measures have on the amount of bulk water supplied and the net economic returns across a complex multi-nodal catchment. It is argued that because it is policymakers who make decisions regarding these measures, an assessment of the private benefits to a subset of users would not be adequate. Rather, the society wide costs and benefits need to be considered. Using a hydroeconomic model of the catchment it was found that reducing the level of reliability was the most beneficial outcome from both a physical and economic perspective. The other three measures were found to have some adverse impacts on regions not directly affected by the measure.
The Impact of the “Belt and Road Initiative” on International Scholarship Students
Authors: Shih Lea , Cao Wei
Published: April 2022

The Belt and Road Initiative (BRI) has had a significant impact on China in political, economic, and cultural terms. This study focuses on the cultural domain, especially on scholarship students from the countries that signed bilateral cooperation agreements with China under the BRI. Using an integrated approach combining the difference-in-differences method and the gravity model, we explore the correlation between the BRI and the increasing number of international scholarship students funded by the Chinese government, as well as the determinants of students' decision to study in China. The panel data from 2010 to 2018 show that the launch of BRI has had a positive impact on the number of scholarship students from BRI countries. The number of scholarship recipients from non-BRI countries also increased, but at a much slower rate than those from BRI countries. The sole exception is the United States, which has trended downward for both state-funded and self-funded students.
A New Reference Axis for Tibial Component Rotation in Total Knee Arthroplasty: A Three-dimensional Computed Tomography Analysis
Authors: Jin Yan , Li Pingyue , Yang Yiming , Zeng Xianli , Shen Hongyuan , Zhang Lihang , Tsai Tsung-Yuan , Chen Jiarong
Published: April 2022

The purpose of this study was to introduce a new reference axis for tibial rotation in total knee arthroplasty (TKA) and verify its reliability. A consecutive series of 80 knees that underwent TKA from 2018 to 2020 as well as 80 healthy knees were analyzed using a three-dimensional tibial model. A coordinate system was established based on the standard TKA tibial cut. The line connecting the lateral-tibial eminence and the medial 1/3rd of the tibial tubercle or the medial border of the tibial tubercle was identified as the lateral eminence line (LE line) and the medial lateral eminence line (MLE line), respectively. To evaluate the reliability of the new reference axis, Akagi's line, the medial third of the tibial tubercle (1/3 line) was compared with the LE and MLE lines by measuring the angle between the lines and the Z-axis. In the coronal view, the intersection angle (TPA), which is composed of the line connecting the center of the medial and lateral tibial plateau with the Z-axis, was measured. The mean angle between Akagi's line and the Z-axis in the healthy group and the osteoarthritis (OA) group was 87.57 ± 3.48° and 87.61 ± 3.47°, respectively. The mean angle between the LE line and Z-axis in the healthy and OA groups was 87.15 ± 4.13° and 86.78 ± 3.95°, respectively. A weak correlation was found between the TPA and Akagi's line and the 1/3 line. A moderate correlation was observed between the TPA and LE lines. There were no significant differences between the healthy and OA groups (P > 0.05) in any of the four reference axes. The LE line showed excellent intra- and inter-observer reliability and reproducibility. The novel and easily drawn LE line is a preferable option for tibial component rotational alignment in TKA.
Perioperative Management of Patient with Esophageal Carcinoma and Crigler-Najjar Syndrome Type 2: A Case Report
Authors: Ma Dehua , Chen Fang , Chen Xiaoyun , Chen Yu
Published: April 2022

Background

Crigler-Najjar syndrome type 2 (CNS-II) is a rare genetic disease that is associated with a lack of uridine diphosphate-glucuronosyltransferase. Esophageal carcinoma is the sixth most common cause of cancer-related death worldwide, for which surgery is the most effective treatment. Reports on patients with both conditions requiring surgery are limited and The impact of hyperbilirubinemia caused by CNS-II on the perioperative period is unknown. Previous studies have found that patients with Crigler-Najjar syndrome have an increased risk of gallstones and related complications, which also poses corresponding challenges to the treatment. Herein, we present a patient with CNS-II who underwent successful thoracoscopic surgery for esophageal carcinoma.

Case summary

A 65-year-old male presented to our hospital with a choking sensation after eating. A physical examination showed yellowing of the sclera and skin. The patient manifested persistent jaundice since birth and had visited many hospitals, but the cause remained undiagnosed. We performed genetic testing, which confirmed CNS-II. Gastroscopy indicated esophageal carcinoma. A multidisciplinary team discussion was carried out to determine the appropriate treatment and perioperative management for this patient. The results show that surgical resection was the most appropriate approach. Finally, the patient underwent thoracoscopic surgery for esophageal carcinoma without complications.

Conclusion

Esophageal carcinoma in patients with Crigler-Najjar syndrome is a rare case, and perioperative management is key in the treatment process. It is necessary to pay close attention to the changes of the disease to prevent complications.
Multi-Scale Modeling Recapitulates the Effect of Genetic Alterations Associated With Diffuse Large B-Cell Lymphoma in the Germinal Center Dynamics
Authors: Merino Tejero Elena , Mao Qirong , Lashgari Danial , García-Valiente Rodrigo , Robert Philippe A. , Meyer-Hermann Michael , Rodríguez Martínez María , Guikema Jeroen E. J. , Hoefsloot Huub H. C. , van Kampen Antoine H. C.
Published: April 2022

Diffuse large B-cell lymphoma is the most common subtype of non-Hodgkin’s lymphoma. It is a germinal center (GC)–derived, aggressive, and heterogeneous disease. Several transcription factors and signaling pathways that play a central role in the progression of the GC reaction and B-cell differentiation have been shown to play an oncogenic role in diffuse large B-cell lymphoma. B-cell lymphoma 6 (BCL6) is a transcriptional repressor that induces the GC B-cell phenotype and blocks plasma cell (PC) differentiation, while interferon regulatory factor 4 (IRF4) and B lymphocyte-induced maturation protein 1 (BLIMP1), a transcriptional promoter, both mediate PC differentiation and exit from the GC (1). Computational models are useful alternatives to trial-and-error experimental investigation. Ordinary differential equation (ODE) models have been used to study different known mechanisms of lymphomagenesis and suggest candidate tumorigenic alterations (2). Furthermore, multi-scale models (MSMs) have been used to study the role of cellular and molecular mechanisms involved in tumor growth (3–6). In this study, we used an existing MSM of PC differentiation in the GC to simulate eight different models with several candidate genetic alterations of the BCL6-IRF4-BLIMP1 regulatory network that lead to transcription factor deregulation and could explain the onset of diffuse large B-cell lymphoma and recapitulate the GC dynamics observed in such conditions. We observed that models with loss of BLIMP1 function (BLIMPloss and BLIMPlossIRFinc) result in an accumulation of B cells in the GC and a block of PC differentiation and thus correctly recapitulate the observed GC and transcription factor dynamics. Models with constitutive activation of the nuclear factor kappa-light-chain-enhancer of activated B-cell (NF-kB) pathway alone and in codominance or co-expression with the enforced BCL6 expression (IRFinc and BCLincIRFinc) result in a decrease of GC B cells and unaltered PC production at early stages of the GC reaction, as observed experimentally. Interestingly, we also found that in IRFinc and BCLincIRFinc models, an increase in PC production could happen at later stages of the GC reaction. Nevertheless, models with enforced BCL6 expression (BCLauto and BCLinc) result in an expansion of GC B cell population and a block in the PC production that was not observed experimentally. Finally, models with loss of IRF4- and BLIMP1-mediated silencing of BCL6 (IRFsil and BLIMPsil) did not affect GC and transcription factor dynamics.
Emergency Fostering of Dogs From Animal Shelters During the COVID-19 Pandemic: Shelter Practices, Foster Caregiver Engagement, and Dog Outcomes
Authors: Gunter Lisa M. , Gilchrist Rachel J. , Blade Emily M. , Reed Jenifer L. , Isernia Lindsay T. , Barber Rebecca T. , Foster Amanda M. , Feuerbacher Erica N. , Wynne Clive D. L.
Published: April 2022

Each year, millions of dogs enter thousands of animal shelters across the United States. Life in the shelter can be stressful, and one type of intervention that improves dogs' experience is human interaction, particularly stays in foster homes. Prior research has demonstrated that fostering can reduce dogs' cortisol and increase their resting activity. Despite these benefits, little is understood about the utilization of foster caregiving in animal shelters, and even less so during a crisis. On March 11, 2020, the World Health Organization deemed the coronavirus outbreak a worldwide pandemic, and subsequently a nationwide emergency was declared in the United States. Nearly all states issued stay-at-home orders to curb the spread of the virus. During this time, media outlets reported increased interest in the adoption and fostering of shelter pets. This study explores canine foster caregiving at 19 US animal shelters during the first 4 months of the COVID-19 pandemic. In our investigation, we found that shelters' utilization of foster caregiving increased from March to April 2020 but returned to initial pandemic levels by June 2020. Slightly less than two-fifths of foster caregivers were community members with no prior relationship with the shelter, and these caregivers were over four times more likely to adopt their fostered dogs than those with a pre-existing relationship to the shelter. Individuals fostering with the intention to adopt, in fact, adopted their dogs in nearly three-quarters of those instances. With regards to shelters' available resources, we found that very low-resource shelters relied more heavily on individuals with prior relationships to provide foster caregiving while very high-resource shelters more often recruited new community members. We also found that our lowest resourced shelters transferred more dogs out of their facilities while more resourced shelters rehomed dogs directly to adopters. To our knowledge, these findings represent the first in-depth reporting about dog fostering in US animal shelters and, more specifically, foster caregiving during the COVID-19 pandemic. In total, they provide greater understanding of how monetary and human resources were utilized to affect the care and ultimately, the outcomes of shelter dogs during this time.
The Spill-Over Impact of the Novel Coronavirus-19 Pandemic on Medical Care and Disease Outcomes in Non-communicable Diseases: A Narrative Review
Authors: Mak Ivy Lynn , Wan Eric Yuk Fai , Wong Teenie Kwan Tung , Lee Wendy Woo Jung , Chan Esther Wai Yin , Choi Edmond Pui Hang , Chui Celine Sze Ling , Ip Mary Sau Man , Lau Wallace Chak Sing , Lau Kui Kai , Lee Shing Fung , Wong Ian Chi Kei , Yu Esther Yee Tak , Lam Cindy Lo Kuen
Published: April 2022

Objectives: The coronavirus-19 (COVID-19) pandemic has claimed more than 5 million lives worldwide by November 2021. Implementation of lockdown measures, reallocation of medical resources, compounded by the reluctance to seek help, makes it exceptionally challenging for people with non-communicable diseases (NCD) to manage their diseases. This review evaluates the spill-over impact of the COVID-19 pandemic on people with NCDs including cardiovascular diseases, cancer, diabetes mellitus, chronic respiratory disease, chronic kidney disease, dementia, mental health disorders, and musculoskeletal disorders.

Methods: Literature published in English was identified from PubMed and medRxiv from January 1, 2019 to November 30, 2020. A total of 119 articles were selected from 6,546 publications found.

Results: The reduction of in-person care, screening procedures, delays in diagnosis, treatment, and social distancing policies have unanimously led to undesirable impacts on both physical and psychological health of NCD patients. This is projected to contribute to more excess deaths in the future.

Conclusion: The spill-over impact of COVID-19 on patients with NCD is just beginning to unravel, extra efforts must be taken for planning the resumption of NCD healthcare services post-pandemic.
Untangling Factors Influencing Women Entrepreneurs’ Involvement in Tourism and Its Impact on Sustainable Tourism Development
Authors: Samad Sarminah , Alharthi Alaa
Published: April 2022

Women’s involvement in tourism has exerted an immense impact on the nation’s economy. The low involvement of women in some countries has sparked the interest of scholars in investigating the factors that influence their involvement. The main purpose of this study was to examine the influence of self-efficacy (SE), perceptions of women’s work (PWW), empowering leadership (EL), and psychological empowerment (PE) on tourism involvement. Consequently, the study determined the impact of tourism involvement in sustainable tourism development (STD). The population of the study was women entrepreneurs from the Saudi Arabia tourism industry. A total of 201 women participated in the study from the selected sample of 300, obtained through convenient sampling. For the data analysis, SPSS and PLS-SEM were employed. The results revealed that PWW, SE, EL, and PE significantly and positively influenced women entrepreneurs’ involvement in tourism (WEIT). Further, WEIT significantly and positively impacted STD. This research is a pioneering work in which a research model was developed to incorporate PWW, SE, EL, PE, tourism involvement, and STD in light of social exchange theory and social identity theory. The findings provide implications for policymakers and academia and contribute to the existing body of knowledge on women’s entrepreneurship, empowerment, tourism, and business management.
Application of Infrared Imaging for Early Detection of Downy Mildew (Plasmopara viticola) in Grapevine
Authors: Zia-Khan Shamaila , Kleb Melissa , Merkt Nikolaus , Schock Steffen , Müller Joachim
Published: April 2022

Late detection of fungal infection is the main cause of inadequate disease control, affecting fruit quality and reducing yield of grapevine. Therefore, infrared imagery as a remote sensing technique was investigated in this study as a potential tool for early disease detection. Experiments were conducted under field conditions, and the effects of temporal and spatial variability in the leaf temperature of grapevine infected by Plasmopara viticola were studied. Evidence of the grapevine’s thermal response is a 3.2 °C increase in leaf temperature that occurred long before visible symptoms appeared. In our study, a correlation of R2 = 0.76 at high significance level (p ≤ 0.001) was found between disease severity and MTD. Since the pathogen attack alters plant metabolic activities and stomatal conductance, the sensitivity of leaf temperature to leaf transpiration is high and can be used to monitor irregularities in temperature at an early stage of pathogen development.
A Bio-Economic Model for Improving Irrigated Durum Wheat Performance and Regional Profits under Mediterranean Conditions
Authors: Mazhoud Houda , Chemak Fraj , Belhouchette Hatem , Chenoune Roza
Published: April 2022

Irrigated durum wheat is a staple food crop that occupies important areas in Tunisia. However, its performance remains weak, with an average national yield of no more than 3.6 tons ha−1 and low profitability. Overall, on-farm wheat production will need to increase considerably to meet future demand and ensure minimum profitability for farmers. To this end, this study aims to identify the main levers for improving durum wheat crop performance. For this purpose, we have developed a regional bio-economic model by linking a biophysical model (CROPSYST) with an economic optimization model (MORBIT). CROPSYST was used to establish a database with a view to determining the relationships between farming practices, durum wheat yields, and water productivity within a context of high climate variability. The database was then integrated into a MORBIT model that analyzed the effects of farming practices on durum wheat performance and regional profits. Three scenarios related to irrigation control and the increase in durum wheat prices were developed. The results showed that reconciling irrigation practices with economic policies is the best alternative to improve durum wheat performance and increase profits at a regional level.
Effect of a Ridge-Furrow Mulching System and Limited Supplementary Irrigation on N2O Emission Characteristics and Grain Yield of Winter Wheat (Triticum aestivum L.) Fields under Dryland Conditions
Authors: Xu Yueyue , Wang Yingxin , Ma Xiangcheng , Cai Tie , Jia Zhikuan
Published: April 2022

Knowledge of the characteristics of N2O emissions and the influential mechanism is of great significance to mitigate greenhouse gas emissions in semi-arid areas. In the present study, a three-year water-control study was conducted; three simulated rainfall amounts (heavy, normal, and light rainfall = 275, 200, and 125 mm, respectively), two wheat (Triticum aestivum L.) planting modes (RF (ridge–furrow mulching system) and TF (traditional flat planting)) and four supplementary irrigation amounts (150, 75, 37.5, and 0 mm) were set up. The effects of different cultivation methods and irrigation amounts on soil N2O emissions, the soil water content, available nitrogen content, and denitrifying enzyme activity were investigated to clarify the N2O emission mechanism in winter wheat fields (Triticum aestivum L.). The results obtained after three years showed that compared with TF, the N2O emissions under RF decreased by 21.62–30.72% (p < 0.001), whereas the soil water content increased by 6.26–8.82%, the available nitrogen content decreased by 1.71–16.24%, and the denitrifying enzyme activities increased by 0.2–24.16% under heavy rainfall conditions. Under conditions with normal and light rainfall, the N2O emission fluxes under RF increased by 3.66–12.46% and 6.08–15.57% (p > 0.05), while the soil water contents increased by 6.13–11.49% and 8.05–13.88%, the soil available nitrogen contents decreased by 11.0–21.42% and 19.93–34.44%, and the denitrifying enzyme activities increased by 0.01–24.08% and 0.03–20.79% compared with TF. Principal component analysis showed that the main factors related to N2O emissions under RF were the soil moisture content and available nitrogen content; these factors combined explained 94.37% the variation of the N2O emissions. However, the main factors under TF were the soil moisture content and denitrifying enzyme activity; these factors combined explained 85.81%. In the heavy and normal rainfall years, compared with TF, using RF and 75 mm irrigation achieved the goal of reducing water usage as well as decreasing the N2O emissions (or N2O increase was not significant). In light rainfall years, RF with 150 mm irrigation obtained significant reductions in water usage compared with TF but it also increased the N2O emission flux. Under different rainfall years, the yield of RF increased by 2.89–50.44% compared with the TF system, and the increase in wheat grain yield increased with decreasing rainfall.
The Seed Quality Assurance Regulations and Certification System in Soybean Production—A Chinese and International Perspective
Authors: Chen Shwu-Pyng Joanna , Li Man-Wah , Wong Ho-Yan , Wong Fuk-Ling , Wu Tingting , Gai Junyi , Han Tianfu , Lam Hon-Ming
Published: April 2022

Soybean is an important and valuable crop for global food and feed supply, providing high-quality nutrition. Globally, five countries—namely Brazil, the USA, Argentina, China and India—have dominated soybean production for many years. The intention of this paper is to review the reasons for their dominance, starting with seeds. High-quality seeds enable stress-free, high-density and even planting of soybean in the field. Seed quality assurance is essential for the successful expansion of soybean cultivation. The aim of this review is to compare and contrast the factors impacting soybean seed production in these top five soybean-producing countries, including the situations at different stages of the supply chain; research and development on new soybean varieties; and regulations, rules and quality assurance systems (seed testing, certification and labeling). Since the soybean supply chain involves many different operating parties, principles and practices, efforts on different fronts need to be well coordinated by a central authority to ensure successful production. Recently, China has implemented a revised national “Seed Law”. The possible impacts of this new legal framework on soybean seed development and trading in China are also discussed. The strengthened China Seed law to protect resources and encourage variety innovation, as well as the clearer China GM soybean commercial release policy, implies future soybean cultivation expansion with elite varieties. A continuous global production increase will require every party’s compliance to the sustainability principles.
Effects of Temperature and Radiation on Yield of Spring Wheat at Different Latitudes
Authors: Zhang Zhenzhen , Zhou Nianbing , Xing Zhipeng , Liu Bingliang , Tian Jinyu , Wei Haiyan , Gao Hui , Zhang Hongcheng
Published: April 2022

It is of great importance to investigate spring wheat yield affected by the climate at different latitudes in the Rice-Wheat Rotation System. Two spring wheat varieties used as the study objects were planted at two locations of different latitudes in 2017–2018 and 2018–2019. Six sowing dates were selected for planting the wheat seeds. The quantity of basic seedlings for the first sowing date was 300 × 104 ha−1, which was increased by 10% on each date in the following sowing proceeding. Results showed that as the latitude increased, the mean daily temperature and effective accumulated temperature decreased, the mean solar radiation and accumulated solar radiation increased; as the effective accumulated temperature decreased, the yield decreased by 0.18 t ha−1 on average; and dry matter accumulation decreased by 0.6 t ha−1 on average. As the sowing date was delayed, the mean daily temperature and mean daily solar radiation increased, and the effective accumulated temperature and accumulated solar radiation decreased. Due to the decrease in the accumulated solar radiation and increase in mean daily temperature, the yield decreased by 0.27 t ha−1 on average and the dry matter decreased by 0.39 t ha−1 on average by postponing one sowing date. The effective accumulated temperature and accumulated solar radiation were significantly positively correlated with wheat yield and dry matter accumulation, and the mean daily temperature was significantly negatively correlated with wheat yield and dry matter accumulation. The temperature productivity at a high latitude was higher than lower latitude. The radiation productivity at a high latitude was lower than lower latitude. The productivity of the temperature and radiation first increased and then decreased when the sowing time was delayed.
The Interactions between Some Free-Ranging Animals and Agriculture—A Review
Authors: Kuka Aleksandra , Czyż Katarzyna , Smoliński Jakub , Cholewińska Paulina , Wyrostek Anna
Published: April 2022

When humans began interfering with the environment to produce food, some free-ranging animal species adapted to live on typical farmland, sometimes choosing it as their main habitat. They use it on the basis of symbiosis or as a pest. The animals affect farms in different ways, and the same concerns farms affecting animals. There are negative, from a human perspective, as well as positive aspects of this interaction. The aim of this study was to review and propose the solutions to reconcile these two factors, agriculture and wildlife, using Poland as an example. Two major problems were observed: the negative impact of agriculture on the occurrence or abundance of certain species, and wildlife damage caused mainly by wild boars (Sus scrofa) and Cervidae. The most important issue for agricultural economy is the strict control and limitation of the wild boar population, while the farmer’s approach to cultivation and the environment are important for the wildlife. For years, man has been undertaking various activities using and subordinating elements of the environment, and each even small interference in the system that creates a harmony will have far-reaching consequences.