bluuebunny/crossref_metadata_2025 huggingface dataset:
Research on Dual-Wavelength Absolute Ranging Technology Based on FMCW Laser Interference
Authors: Sun Bin , Song Junfang
Published: December 2021

FMCW (Frequency-Modulated Continuous Wave) interferometer can achieve high-precision displacement measurement by phase discrimination of the interference signal. The phase needs to be superimposed continuously, so the optical path cannot be interrupted in the measurement process. To solve this problem, a new absolute ranging technology - decimal comparison method is proposed in the manuscript. According to the principle of FMCW interference, two DFB lasers with different central wavelengths are used to measure the same target. The sampled interference signal is processed by digital signal processing to calculate the integer and decimal of the synthetic wavelength period. The optical path difference of the target is calculated by the established mathematical model. The experimental results show that this method not only ensures the measurement accuracy, but also realizes the absolute measurement, and expands the application range of FMCW interferometry.
Metabolic Equivalents of Safe Physical Activity Levels at Anaerobic Threshold in Anorexia Nervosa Patients
Authors: Makoto Yamashita , Keisuke Kawai , Kenta Toda , Chie Aso Suzuyama , Takafumi Suematsu , Hiroaki Yokoyama , Tomokazu Hata , Shu Takakura , Nobuyuki Sudo
Published: December 2021

Purpose Patients with anorexia nervosa (AN) require appropriate nutrient therapy and physical activity management. Eating disorder treatment guidelines do not include safe, evidence-based intensity criteria for exercise. This study used cardiopulmonary exercise testing (CPX) to evaluate the exercise tolerance of patients with AN and develop treatment guidelines to optimize their physical activity. Methods CPX was done with 14 female AN patients admitted to a specialized eating disorder unit between 2015 and 2019. Their anaerobic threshold (AT) was determined by assessing their exercise tolerance using CPX and compared with 14 healthy controls (HC). The metabolic equivalents (AT-METS) were compared when AT was reached. We examined factors related to AT (AN-AT) in the AN group, including age, body mass index (BMI), previous lowest weight, minimum BMI, past duration of BMI < 15, exercise history, and ΔHR (heart rate at the AT - resting heart rate). Results The AT of the AN group (BMI: 15.7 [Mean] ± 1.8 [SD]) was significantly lower than the HC group (BMI: 19.7 ± 1.8) (AN: 10.0 ± 1.8 vs HC: 15.2 ± 3.0 ml/kg/min, P<0.001). AT-METS was also significantly lower in the AN than the HC group (AN: 2.9 ± 0.52 vs HC: 4.4 ± 0.91, P<0.001). AN-AT was highly influenced by ΔHR. Conclusion The AT-METS level for these AN patients was 2.5-3.3 METS, and this index can be used by clinicians to teach AN patients a safe exercise intensity. CPX and AT-METS are useful tools for clinicians to manage physical activity in AN patients. Level of evidence III: Evidence obtained from case-control analytic studies
Public Health and Social Measures to Mitigate the Health and Economic Impact of the COVID-19 Pandemic in Turkey, Egypt, Ukraine, Kazakhstan, and Poland During 2020-2021: Situational Analysis
Authors: Kitamura Noriko , Abbas Kaja , Nathwani Dilip
Published: December 2021

Background

The COVID-19 pandemic had enormous impacts on human society. There were similarities and differences in the public health and social measures taken by countries, and comparative analysis facilitates cross-country learning of contextual practices and sharing lessons to mitigate the COVID-19 pandemic impact. We aim to conduct a situational analysis of the public health and social measures to mitigate the health and economic impact of the COVID-19 pandemic in Turkey, Egypt, Ukraine, Kazakhstan, and Poland during 2020-2021.
Methods

We conducted a situational analysis of the COVID-19 pandemic response in Turkey, Egypt, Ukraine, Kazakhstan, and Poland from the perspectives of the health system and health finance, national coordination, surveillance, testing capacity, health infrastructure, healthcare workforce, medical supply, physical distancing and non-pharmaceutical interventions, health communication, impact on non-COVID-19 health services, impact on the economy, education, gender and civil liberties, and COVID-19 vaccination.
Results

Since the onset of the COVID-19 pandemic, Turkey, Egypt, Ukraine, Kazakhstan, and Poland have expanded COVID-19 testing and treatment capacity over time. However, they faced a shortage of healthcare workforce and medical supplies. They took population-based quarantine measures rather than individual-based isolation measures, which significantly burdened their economies and disrupted education. The unemployment rate increased, and economic growth stagnated. Economic stimulus policy was accompanied by high inflation. Despite the effort to sustain essential health services, healthcare access declined. Schools were closed for 5-11 months. Gender inequality was aggravated in Turkey and Ukraine, and an issue was raised for balancing public health measures and civil liberties in Egypt and Poland. Digital technologies played an important role in maintaining routine healthcare, education, and public health communication.
Conclusions

The COVID-19 pandemic has exposed weaknesses in healthcare systems in emerging countries of Turkey, Egypt, Ukraine, Kazakhstan, and Poland, and highlighted the intricate link between health and economy. Individual-level testing, isolation, and contact tracing are effective public health interventions in mitigating the health and economic impact of the COVID-19 pandemic in comparison to population-level measures of lockdowns. Investment in health, including digital health and communication, is essential to minimize the impact of the pandemic and for more equitable and sustainable development beyond the pandemic.
FRET-FISH probes chromatin compaction at individual genomic loci in single cells
Authors: Mota Ana , Wernersson Erik , Li-Wang Xiaoze , Gradin Katarina , Crosetto Nicola , Bienko Magda
Published: December 2021

The density or compaction of chromatin throughout the cell nucleus is a key biophysical property that influences DNA replication, transcription, and repair. Chromatin accessibility is often used as a proxy for chromatin compaction or density, however it is not clear how these two properties relate to each other, given the lack of tools for directly probing compaction at defined genomic loci. To fill in this gap, here we developed FRET-FISH, a microscopy-based method combining fluorescence resonance energy transference (FRET) with DNA fluorescence in situ hybridization (FISH) to probe chromatin compaction at selected loci in single cells. We optimized FRET-FISH by testing different probe designs in situ in fixed cells, readily detecting FRET generated by DNA FISH probes. To validate FRET-FISH, we compared it with ATAC-seq and Hi-C, demonstrating that local chromatin compaction and accessibility are strongly correlated and that the frequency of intra-genic contacts measured by Hi-C may be an even better proxy for local chromatin density. To further validate FRET-FISH, we showed that it can detect expected differences in chromatin compaction along the nuclear radius, with peripheral loci being more compacted and central ones less compacted. Lastly, we assessed the sensitivity of FRET-FISH, demonstrating its ability to reproducibly detect differences in chromatin density (i) upon treatment of cells with drugs that perturb global chromatin condensation; (ii) during prolonged cell culture; and (iii) in different phases of the cell cycle. We conclude that FRET-FISH is a robust tool for probing chromatin compaction at selected loci in single cells and for studying inter-allelic and cell-to-cell variability in chromatin density.
Diagnostic Agreement of Quantitative Flow Ratio with Fractional Flow Reserve in a Latin-American Population
Authors: Pinto Mauro Echavarria , de Hoef Tim P. Van , Pacheco-Beltran Nancy , Reyes-Carrera Jesus Eduardo , Rangel-Alvarado Eduardo , Ledezma-Ledezma Elizabeth , Aguilar-Castillo Laura Alicia , Tovar-Becerra Andrea Itzel , Arellano Juan Ernesto Muñoz , Ramírez María Neftalí Maqueda , Ibarra-Rangel Ana Maria , Montes-Collantes Carlos Alberto , Castrejon-Mora Jorge Luis , Benitez Irma Hualtal Chong , Vargas-Torrrescano Luis Homero , García-García Hector M.
Published: December 2021

Purpose: Quantitative flow ratio (QFR) is a recently proposed angiographic index that allows to assess the pressure loss in coronary arteries in a similar fashion as the accepted standard fractional flow reserve (FFR). The purpose of this study was to evaluate the diagnostic performance of QFR as compared to FFR, in a Latin-American population of patients with suspected ischaemic heart disease.Methods: QFR was retrospectively derived from coronary angiograms. The association, diagnostic performance, and continuous agreement of fixed-flow QFR (fQFR) and contrast-flow QFR (cQFR) with FFR was assessed by continuous and dichotomous methods.Results: 90 vessels form 63 patients were finally included. The study comprised coronary stenoses of intermediate severity, both angiographically (diameter stenosis: 46.6 ± 12.8%) and physiologically [median FFR=0.86 (quartile 1-3, 0.76-0.89)]. The correlation of FFR with both fQFR [ρ=0.841, (95% CI: 0.767 to 0.893), p<0.001] and cQFR [ρ=0.833, (95% CI: 0.755 to 0.887), p<0.001] was strong. The diagnostic performance of cQFR was numerically better [area under the ROC curve of 0.92 (95% CI: 0.86 to 0.97, p<0.001)], with 0.80 as the optimal cQFR cut-off against FFR≤0.80. This 0.80 cQFR cut-off classified correctly 83.3% of total stenoses, with a sensitivity of 85.2% and specificity of 80.6%.Conclusions: QFR was strongly associated with FFR and exhibited a high diagnostic performance in this Latin-American population.
Family Planning Films: Fact or Fiction? A Qualitative Study Assessing Changes in Knowledge, Attitudes, and Intentions to use Family Planning After Watching Documentary and Drama Health Education Films
Authors: MUBANGIZI VINCENT , Plastow Jane , Nakaggwa Florence , Nahabwe Haeven , Natukunda Sylvia , Atim Fiona , Mawere Brenda , Laughton Matthew , Muller Ingrid , Owokuhaisa Judith , Coates Sabine , Chambers Isabella , Goodhart Clare , Willcox Merlin
Published: December 2021

Background: There is a paucity of literature on the effectiveness of drama or documentary films in changing knowledge, beliefs, attitudes, and behavior of people towards family planning. This study aimed to compare and assess the acceptability of health promotion films based on documentary or drama, and their effect on knowledge, attitudes, and intention to use family planning.Methods: We developed short documentary and drama films about contraceptive implants, using the person-based approach. Their acceptability was assessed in focus group discussions with younger women below 23 years, women over 23 years, men of reproductive age, and health workers in four different areas of Uganda (Bwindi/Kanungu, Walukuba/Jinja, Kampala, and Mbarara). Transcripts of the focus group discussions were analyzed using thematic analysis, to generate themes and examine the key issues. We assessed changes in knowledge, attitudes, and intentions to use family planning after watching the films. Results: Sixteen focus groups with 150 participants were carried out. Participants said that the documentary improved their knowledge and addressed their fears about side effects, myths, and implant insertion. The drama improved their attitudes towards the implant and encouraged them to discuss family planning with their partner. The final versions of the documentary and the drama films were equally liked. Conclusions: Viewing a short documentary on the contraceptive implant led to positive changes in knowledge, while a short drama improved attitudes and intentions to discuss the implant with their partner. The drama and documentary have complementary features, and most participants wanted to see both.
Mitochondrial And Myogenic Gene Expression Pathways Are Influenced By The Exercise Mimetic Formoterol In Human Myotubes
Authors: Duplanty Anthony A. , Zumbro Emily L. , Gordon Ryan A. , Guerin Gena D. , Brisebois Matthew F. , Sokoloski Matthew L. , Rigby Brandon R.
Published: December 2021

Background: Exercise is an effective treatment for establishing and maintaining skeletal muscle (SKM) health. The interconnected cascade of gene expression pathways related to myogenesis, mitochondrial homeostasis, and thyroid hormone metabolism are critical to SKM health. This in vitro study was conducted to investigate the effects of exercise mimetic (formoterol) stimulation on human SKM cell signaling during myogenesis, and to provide insight on potential targets for future studies exploring therapies for SKM atrophy.Methods: Human myoblasts were cultured and differentiated to evaluate the effects of exercise mimetic stimulation on gene expression during mid and late myogenesis. We characterized the expression of 24 genes related to myogenesis, mitochondrial biogenesis, thyroid hormone metabolism, and cellular homeostasis.Results: Formoterol stimulated the gene expression for SKM pathways related to mitochondrial biogenesis, thyroid metabolism, and cellular homeostasis. Additionally, formoterol resulted in a myogenic program that appears to favor prolonged myoblast proliferation and delayed myotube maturation.Conclusion: Robust, yet differential effects of exercise mimetic stimulation on gene expression during mid-myogenesis and at terminal differentiation were found. The results of our study support the groundwork for establishing further experiments utilizing exercise signaling as a therapeutic treatment in models targeting dysfunctional SKM cell growth.
Optimal Unambiguous Discrimination And Quantum Nonlocality Without Entanglement: Locking And Unlocking By Post-Measurement Information
Authors: Ha Donghoon , Kim Jeong San
Published: December 2021

The phenomenon of nonlocality without entanglement(NLWE) arises in discriminating multi-party quantum separable states. Recently, it has been found that the post-measurement information about the prepared subensemble can lock or unlock NLWE in minimum-error discrimination of non-orthogonal separable states. Thus it is natrual to ask whether the availability of the post-measurement information can influence on the occurrence of NLWE even in other state-discrimination stratigies. Here, we show that the post-measurement information can be used to lock as well as unlock the occurence of NLWE in terms of optimal nambiguous discrimination. Our results can provide a useful application for hiding or sharing information based on non-orthogonal separable states.
On the accuracy of emitter localization method based on multipath exploitation in realistic scenarios
Authors: Imran Md Abdullah Al , Arik Eray , Dalveren Yaser , Tabakcioglu Mehmet Baris , Kara Ali
Published: December 2021

This study aims to evaluate the accuracy of a method proposed for passive localization of radar emitters around irregular terrains with a single receiver in Electronic Support Measures (ESM) systems. Previously, only the theoretical development of the localization method was targeted by the authors. In fact, this could be a serious concern in practice since there is no evidence about its accuracy under the real data gathered from realistic scenarios. Therefore, firstly, an accurate ray-tracing algorithm is adapted to the method in order to enable its implementation in practice. Then, scenarios are determined based on the geographic information system (GIS) map generated to collect high resolution digital terrain elevation data (DTED) as well as realistic localization problems for radar emitters. Next, the improved method is tested with simulations, and thus, its performance is verified for practical implementation in Electronic Warfare (EW) context for the first time in the literature. Lastly, based on the simulation results, the performance bounds of the method are also discussed.
WITHDRAWN: Young and Old Leaves Physiological and Metabolite Profiles Analysis on Amino Acids and Organic Acids in Wild Soybean Seedlings Under Nitrogen Deficiency
Authors: Liu Yuan , Gao Shujuan , Hu Yunan , Zhang Tao , Guo Jixun , Shi Lianxuan
Published: December 2021

Background
As an important germplasm resource, wild soybean has good tolerance to complex stress environment stress. This study described the differences of physiological and metabolomic changes between common wild soybean (GS1) and the barren tolerance wild soybean (GS2) under low nitrogen (LN) stress.
Results
The result showed the barren tolerance wild soybean young leaves can maintain relatively stable chlorophyll content and increased the contents of Car;Photosynthetic rate and transpiration rate decreased significantly in in the barren tolerance wild soybean old leaves, but there was no significant change in young leaves; the barren tolerance wild soybean enhanced the enrichment of beneficial ion pairs such as zinc, calcium and phosphorus. The metabolism of amino acids and organic acids in the barren tolerance wild soybean old leaves was vigorous, a large number of beneficial amino acids such as GABA, asparagine and proline were enriched, and the metabolites related to TCA cycle were significantly increased.
Conclusion
the barren tolerance wild soybean can ensure the nitrogen supply of young leaves by inhibiting the photosynthetic response of old leaves; the relatively stable growth of young leaves also benefits from the effective transport and reuse of beneficial ions from old leaves; More importantly, the enhanced metabolism of specific amino acids and organic acids in GS2 old leaves seemed to play an important role in resisting LN stress. GABA and Asparagine played substantial roles in N storage, C/N balance, antioxidant defense and act as signaling molecule to help GS2 to resist LN stress. Difference organic acids in the old leaves of GS2 increased which could improve the utilization rate of N in the soil. In addition, the strength of fatty acids catabolism and TCA cycle in GS2 old leaves provided energy base for substance transport. The analysis of physiological and metabolite may provide a new perspective for revealing the importance of substance transport and reuse in different plant parts to resist abiotic stress.
Assessment of Telomere Length and Molecular Characterization of TERT Gene Promoter in Periampullary Carcinomas
Authors: Gregório Cleandra , Thakur Shefali , Rivero Raquel Camara , Machado Simone Márcia dos Santos , Cuenin Cyrille , Carreira Christine , White Valerie , Cree Ian A , Vukojevic Katarina , Durdov Merica Glavina , Osvaldt Alessandro Bersch , Ashton-Prolla Patricia , Herceg Zdenko , Talukdar Fazlur Rahman
Published: December 2021

Genetic and epigenetic alterations of the telomere maintenance machinery like telomere length and telomerase reverse transcriptase (encoded by TERT gene) are reported in several human malignancies. However, there is limited knowledge on the status of the telomere machinery in periampullary carcinomas (PAC) that are rare and heterogeneous groups of cancers arising from different anatomic sites around the ampulla of Vater. In the current study, we investigated the relative telomere length (RTL) and the most frequent genetic and epigenetic alterations in the TERT promoter in PAC (n=20) and compared with tumor-adjacent nonpathological duodenum (NDu; n=16). We found shorter RTLs (1.27 vs 1.33, P=0.01) and lower TERT protein expression (p=0.04) in PAC tissues as compared to the NDu. Although we did not find any mutation at two reactivating hotspot mutation sites of the TERT promoter, we detected polymorphism in 55% (11/20) of the cases at rs2853669 (T>C). Also, we found a hypermethylated region in the TERT promoter of PACs consisting of four CpGs (cg10896616 with ∆β 7%; cg02545192 with ∆β 9%; cg03323598 with ∆β 19%; and cg07285213 with ∆β 15%). In conclusion, we identified shorter telomeres with DNA hypermethylation in the TERT promoter region and lower TERT protein expression in PAC tissues. Further studies with a larger sample size are necessary to substantiate these results.
Identification the key genes between polycystic ovary syndrome and Non-Alcoholic Fatty Liver Disease
Authors: Yifu Pu
Published: December 2021

Purpose Many studies show correlation between polycystic ovary syndrome(PCOS) and non-alcoholic fatty liver disease(NAFLD),but the underlying pathogenic genes are not clear. This study by using the bioinformatics method aims to search the key genes involved in these 2 diseases.
Methods The Gene Expression Omnibus (GEO) datasets coming from the GEO database GSE63067 -NAFLD patients and healthy controls, and GSE34526 -PCOS patients and normal controls, are downloaded. Differentially expressed genes (DEGs) of 2 diseases datasets and the common genes are obtained. After GO and KEGG enrichment analyses of common genes are performed. To find the key genes between NAFLD and PCOS, a protein–protein interaction (PPI) network is carried out. In addition, the diagnostic value of key genes in PCOS is analyzed.
Results According to NAFLD and PCOS downloaded datasets,34 common genes,21 key genes,15 GO terms and 4 KEGG pathways are obtained. Further,based on the top 6 key genes,the corresponding area under the curve (AUC) by constructing ROC curves in the PCOS is 0.909 (95% CI, 0.775–1.000).
Conclusions The study identify some key genes in the occurrence and progression between NAFLD and PCOS. In the future,to verify our results,it need experimental and clinical research.
Child-centred pandemic decisions: how the Precautionary Principle can generate better risk assessment in an era of uncertainty
Authors: Kvalsvig Amanda , Russell Jin , Timu-Parata Carmen , Baker Michael G.
Published: December 2021

Key messagesRisk assessment for children has been a polarising issue during the Covid-19 pandemic. Governments around the world are preparing to ‘open up’ before risks to children are fully quantified, with unknown implications for their long-term health.Applying the Precautionary Principle to child health requires decision makers to 1) take preventive action until risks are better understood; 2) ensure that the burden of proof rests with proponents of risk; 3) explore alternatives to the risk; and 4) use participatory approaches to decision-making.Policies relating to children must be centred on the rights and wellbeing of children. We provide a framework for comprehensive Health Impact Assessments to ensure that direct and indirect impacts upon children are taken into account in major policy decisions.Elimination strategies offer an integrated approach to the protection of children’s wellbeing, the wellbeing of the population as a whole, and health equity. Where countries are transitioning away from elimination, a tight suppression approach is preferable to loose suppression or mitigation.
Structural-bioinformatics analysis of SARS-CoV-2 variants reveals higher hACE2 receptor binding affinity for Omicron B.1.1.529 spike RBD compared to wild-type reference.
Authors: Durmaz Vedat , Köchl Katharina , Singh Amit , Hetmann Michael , Parigger Lena , Krassnigg Andreas , Nutz Daniel , Korsunsky Alexander , König Centina , Chang Lee , Krebs Marius , Bassetto Riccardo , Pavkov-Keller Tea , Resch Verena , Gruber Karl , Steinkellner Georg , Gruber Christian C.
Published: December 2021

To date, more than 263 million people have been infected with SARS-CoV-2 during the COVID-19 pandemic. In many countries, the global spread came in several pandemic waves characterized by the emergence of new SARS-CoV-2 variants. Here, we report on a sequence- and structural-bioinformatics analysis by which we estimate the impact of amino acid exchanges on the affinity of the SARS-CoV-2 spike receptor-binding domain (RBD) to the human receptor hACE2. This is carried out by qualitative electrostatics and hydrophobicity analysis as well as through molecular dynamics simulations used for the development of a highly accurate linear interaction energy (LIE) binding affinity model that was calibrated on a large set of experimental binding energies. For the newest variant of concern (VOC), B.1.1.529 Omicron, our Halo difference point cloud studies reveal the largest impact on the RBD binding interface compared to any other VOC. Moreover, according to our LIE model, Omicron achieved a substantially higher ACE2 binding affinity than the wild-type and in particular the highest among all VOCs except for Alpha and therefore requires special attention and monitoring. Using this prediction model we provide early structural insight and binding properties before experimentally determined complex structures and binding affinity data become available in the upcoming months.
The Study of Multilayer Graphene Membrane Performance in O2 Purification Process: Molecular Dynamics Simulation
Authors: Jafari Mostafa , Sabetvand Roozbeh
Published: December 2021

We use molecular dynamics (MD) method to describe the atomic behavior of Graphene nanostructure for Oxygen molecules (O2) separation from Carbon dioxide (CO2) molecules. Technically, for the simulation of graphene-based membrane and O2-CO2 gas mixture, we used Tersoff and DREIDING force fields, respectively. The result of equilibrium process of these structures indicated the good stability of them. Physically, this behavior arises from the appropriate MD simulation settings. Furthermore, to describe the purification performance of graphene-based membrane, we report some physical parameters such as purification value, impurity rate, and permeability of membrane after atomic filtering process. Numerically, by defined membranes optimization, the purification value of them reach to 97.31%. Also, by using these atomic structures the CO2 impurity which passed from graphene-based membrane reach to zero value.
Engineering and Fermenter Optimization of Fungi GLA Productions in Pichia Pastoris GS115 Using Oil Waste
Authors: Firoozabad Maryam Sadat Mirbagheri , Akhbariyoon Hamidreza
Published: December 2021

γ-Linolenic acid (GLA) is an important n-6 polyunsaturated fatty acid (PUFA) that has received considerable attention in both levels in human and animal feed. GLA is used in many nutritional and medicinal applications such as the treatment of cancer, inflammatory disorders, and diabetes. Currently, plant seed is the main dietary source of GLA that is not enough to utilize on an industrial scale. To generate a sustainable novel source of GLA, the gene of delta-6 desaturase, which is one of the important enzymes in the GLA production pathway was isolated from Mucor rouxii DSM1194 and expressed in Pichia pastoris GS115 by pPICZC vector. The recombinant yeast expressed the GLA up to 19.2% (72 mg/g) of total fatty acids. GLA production of recombinant yeast was studied in fermenter by oil waste along 5 days and results detected 6.3 g / l lipid and 103 mg/g GLA was produced in 72 hours. The present study may provide an opportunity for the development of an alternative host for manufacturing GLA on an industrial scale.
Peran Rumah Aspirasi "TITIS" dalam Mendampingi Perempuan Korban Kekerasan
Authors: Yasmin Yuditya Firdauza , Ashidiq Heharero Tesar
Published: December 2021

Kekerasan merupakan sebuah mata rantai yang sulit untuk dihapuskan. Fenomena pandemi covid-19 menjadi salah satu katalis dalam tindak kekerasan terhadap perempuan. Jawa Tengah menjadi salah satu provinsi dengan jumlah tertinggi kasus kekerasan terhadap perempuan. Akan tetapi, Kabupaten Kebumen pada tahun 2020 justru mengalami penurunan kasus. Salah satu upaya yang dilakukan oleh pemerintah Kabupaten Kebumen adalah dengan mendirikan Rumah Aspirasi Perempuan “TITIS”. Penelitian ini berusaha untuk menjelaskan lebih jauh lagi terkait peran Rumah Aspirasi Perempuan yang telah didirikan oleh Pemerintah Kabupaten Kebumen dalam mendampingi korban kekerasan dan mendukung upaya pemerintah untuk mengurangi angka kekerasan terhadap perempuan. Penelitian ini menggunakan pendekatan kualitatif. Teknik pengumpulan data yang digunakan adalah wawancara mendalam dan kajian pustaka dengan mengumpulkan data dari berbagai sumber. Rumah aspirasi perempuan titis memiliki tugas pokok dan fungsi melakukan pendampingan terhadap korban-korban kekerasan sekaligus memberikan konseling. Kasus kekerasan berbasis gender dan anak  di Kabupaten Kebumen pada tahun 2020 mengalami penurunan dari tahun 2019. Hal ini dikarenakan banyak korban kekerasan dalam rumah tangga (KDRT) tidak melapor kepada pihak layanan sosial atau dalam hal ini Rumah Aspirasi Perempuan “Titis” maupun kepada layanan sosial yang berada dibawah naungan Dispermades P3A Kabupaten Kebumen. Korban kekerasan cenderung untuk langsung menempuh jalur hukum dan melaporkan kasus kekerasan tersebut ke aparat kepolisian setempat. Selain itu, kurangnya pengetahuan masyarakat menjadi salah satu penyebab rendahnya laporan yang masuk ke rumah aspirasi perempuan titis. Oleh sebab itu, rumah aspirasi titis bekerja sama dengan pemerintah desa guna mendapatkan data tambahan terkait kekerasan terhadap perempuan agar dapat memberikan pendampingan korban.

Kata kunci : Kekerasan, Perempuan, Rumah Aspirasi, Kabupaten Kebumen.
FILSAFAT PRAGMATISME: MENINJAU ULANG INOVASI PENDIDIKAN ISLAM
Authors: Wiranata Rz. Ricky Satria , Maragustam Maragustam , Abrori M. Sayyidul
Published: December 2021

This article is motivated by the fact that educational innovation in Indonesia is still low, this is reflected in the competitiveness of Indonesian human resources which is still weak when compared to Southeast Asian countries. The presence of the theory of pragmatism is expected to be a theoretical alternative to the approach of Islamic education innovation. This article seeks to formulate the design and innovation process of Islamic Education based on qualitative research and literature studies. This article is a philosophical study as an effort to construct the process of Islamic Education innovation from the perspective of Islamic philosophy and pragmatism. This study concludes that the innovation process is a necessity. In the Islamic perspective, aqidah sohihah is the key and initial step in finding the purity of Islamic education innovation. Whereas pragmatism offers an innovative process of Islamic education based on systematic steps that begin with reflective criticism, diagnosis, inventory, reflection, testing of hypotheses, public analysis, and finally implementation.
PENGEMBANGAN SIKAP RELIGIUS PADA ANGGOTA RESIMEN MAHASISWA (MENWA) MAHAPURA IAIN PONTIANAK
Authors: Sukino Sukino , Handini Agus , Wara ‎ Agnia
Published: December 2021

This study discusses efforts to develop religious attitudes among students which are always important to be carried out by institutions through Student activity units independently so that their potential as leaders is honed based on moderate Islamic religious values. The purpose of this study was to obtain information about: 1) program activities designed by the commander and staff in shaping the religious character of the members of the MENWA. 2) challenges faced in implementing program activities in shaping the religious character of members of the Mahapura student regiment. The research approach was qualitative, the data source of this study consisted of primary data sources of menwa and secondary leaders (Menwa members), Mahapura IAIN Pontianak. This study found a program of religious development activities namely, Yasisnan and Tahlilan, Khataman al-Quran, and social care: Menwa Sharing through fundraising, the two challenges faced in developing religious attitudes are forgiving excessive self-weakness, lack of interest in religion, and lack of interest in religion. Sense of responsibility due to feeling tired after participating in activities on campus. This finding becomes a new model for the development of religious attitudes among intra-campus organizations in preparing a generation that is physically strong and has a strong faith
KOMPARASI PERKEMBANGAN POTENSI ANAK USIA DINI MENURUT ISLAM DENGAN TEORI KOHLBERG
Authors: Bahri Saiful
Published: December 2021

Abstrak: Kohlberg sangat memperdulikan perkembangan manusia, sehingga dia mengemukakan tiga tahapan perkembangan potensi manusia, sedangkan Islam sebagai agama yang rahmatan lil ‘alamiin sangat memperdulikan perkembangan manusia, sehingga mengemukakan konsep tentang perkembangan tersebut dalam hadits dan al-Qur’an. Persamaan antara kedua teori tersebut adalah sama-sama mengungkapkan tahapan-tahapan perkembangan anak dan perkembangan potensi anak. Kemudian juga mengungkapkan tahapan pendidikan yang harus dilaksanakan kepada anak supaya anak dapat berkembang sesuai dengan bakat alaminya. Perbedaannya mulai dari perbedaan epistemologi dan juga perbedaan pengembangan konsep fitrah.

 

Kata kunci: Potensi Anak Usia Dini, Teori Kohlberg

Abstract: Kohlberg really cares about human development, so he put forward three stages of human potential development, while Islam as a religion which is rahmatan lil 'alamin really cares about human development, so he put forward the concept of this development in the hadith and the Qur'an. The similarities between the two theories are that they both reveal the stages of child development and the development of children's potential. Then also reveal the stages of education that must be carried out to children so that children can develop according to their natural talents. The differences start from differences in epistemology and also differences in the development of the concept of fitrah.

 

Keywords: Early Childhood Potential, Kohlberg's Theory
Incidence of lateral incisor root resorption associated with impacted maxillary canines
Authors: Lipshatz Jeff , Ptasznik Ronnie , Wenig Shmuli
Published: December 2021

Introduction

The aim of this study was to determine the incidence of lateral incisor root resorption associated with impacted maxillary canines and determine predisposing factors that may be used to predict its occurrence.

Methods

Cone beam computerised tomographic images of 133 patients presenting with 186 impacted canines were examined for lateral incisor root resorption. A control sample consisted of 30 lateral incisors on the side of the non-impacted canine. The studied canine-associated variables were gender, type of impaction, location of the canine both meso-distally and vertically and the long axis angulation to the midline. Axial images were primarily used to diagnose resorption.

Results

The estimated percentage of lateral root resorption in the sample was 17% (range 11.8– 23.9%) confirmed at a 95% confidence interval. A significant association was observed between the level of overlap of the canine across the lateral incisor, measured in sectors, and the probability of lateral incisor root resorption. The probability approximately doubled for each additional sector of canine overlap. No other significant association was noted related to all the other variables examined.

Conclusions

The incidence of lateral incisor root resorption associated with impacted maxillary canines was lower in the present study compared with many previous reports. However, resorption remains a common clinical finding. In order to screen for lateral incisor resorption, it is recommended that a cone beam image be prescribed when there is a mesial overlap of an impacted canine across the lateral incisor midline.
Colonialism and Conservation
Authors: LENNOX ROWENA , PROBYN-RAPSEY FIONA
Published: December 2021

This article describes and analyses the Pelorus experiment, a recent restoration project in which dingoes were used to eradicate goats on a Great Barrier Reef Island. Before they were taken to the island, the dingoes were implanted with a poison capsule that was intended to kill them after they had killed the goats; they were both pest and ‘pesticide’ (Mavhunga 2011). Subsequently, freehold land on the island was marketed as a tourism development site. We contextualise the Pelorus Island goat eradication program within the cultural–political history of carceral colonialism in Australia and show how this experiment relates to ideas about the special role that islands play in conservation. We also piece together the story of what happened to the goats and dingoes involved. Our analysis reveals the ways notions of animal pesthood and ecological restoration are co-opted by conservation and tourism interests. The Pelorus experiment illustrates how illusions of idyllic island sanctuaries, which appeal to contemporary tourism tropes of seclusion within a ‘pristine’ environment, are predicated on the violence inherent to, but obfuscated within, settler-colonialist visions of land for the taking and remaking.
First report of root-lesion nematode, Pratylenchus oleae from pistachio in Iran
Authors: Naeini Farhad Saeidi , Taheri Zahra Majd
Published: December 2021

Pistachio, Pistacia vera is one of the most important cash crops in Iran that is scattered in arid and semi-arid regions. During a survey of plant-parasitic nematodes of pistachio in Ardakan city in Yazd Province, a species of root-lesion nematode was isolated and identified by morphological, morphometrical, and molecular methods as Pratylenchus oleae Palomares-Rius et al., 2014. This species was isolated from several pistachio trees rhizosphere regarding to molecular analysis, D2–D3 expansion segments of 28S rRNA was amplified by PCR and sequenced. The sequence was deposited in GenBank (Accession No. MW338666). Along with the related phylogenetic analysis, placed this species in a monophyletic clade with other Pratylenchus oleae isolates, based on Bayesian inference (BI) phylogeny. A PCR reaction with the P. oleae specific primer set produced a 547 bp fragment. This is the first report of P. oleae infecting Pistachio tree in the world.
Record data from Kies distribution and related statistical inferences
Authors: Al-Olaimat Nesreen M. , Bayoud Husam A. , Raqab Mohammad Z.
Published: December 2021

The Kies probability model was proposed as an alternative to the extended Weibull models as it provides a more efficient fit to some real-life data sets in comparison to the aforementioned models. The paper proposes classical and Bayesian inferences for the Kies distribution based on records. Maximum likelihood estimates are studied jointly with asymptotic and bootstrap confidence intervals. Moreover, Bayes estimates, along with credible intervals are discussed assuming squared and LINEX loss functions. The proposed estimation methods have been investigated and compared via simulation studies. A real data set has been analysed for illustrative purposes.
Relationships for moments of the progressively Type-II right censored order statistics from the power Lomax distribution and the associated inference
Authors: Saran Jagdish , Pushkarna Narinder , Sehgal Shikha
Published: December 2021

In this paper, we establish several recurrence relations between single and product moments of progressively Type-II right censored order statistics from the power Lomax distribution. The relations enable the computation of all the single and product moments of progressively Type-II right censored order statistics for all sample sizes n and all censoring schemes (R
1, R
2,..., R

m
), m ≥ n, in a simple recursive manner. The maximum likelihood approach is used for the estimation of the parameters and the reliability characteristic. A Monte Carlo simulation study has been conducted to compare the performance of the estimates for different censoring schemes.
Technological Capabilities of Medium-Sized Contractors in Indonesia
Authors: Soemardi Biemo W. , Kusuma Bayu , Pribadi Krishna S. , Yuliar Sonny
Published: December 2021

The construction industry plays a significant role in national development and economic growth of Indonesia. Contractors are key actors in the construction industry and manage large amounts of construction resources and activities. While the demand for improving the nation's infrastructure is on the rise, the question remains whether the industry, especially contractors, will be able to fulfil this demand. This study investigates whether contractors include technological capabilities as an important part of their company strategies for addressing the dynamics of the construction industry. In particular, it aims to understand how contractors develop and improve their technological capabilities through a technological learning process (exploration, acquisition and internalisation). The investigation focuses on medium-sized contractors, who often play an important role as part of the supply chain for larger contractors. A model is developed to represent the dynamic interactions between key factors that influence the way contractors select and use technology to enhance their performance. Data were collected through a survey and were then used to map the contractors' development of technological capabilities. The study reveals that medium-sized contractors have yet to consider the development of technological capabilities as strategic. The results are expected to benefit the regulator and construction companies in Indonesia in their efforts to improve the performance of the country's construction industry.
Acute Myeloid Leukemia Patient-Derived Xenograft Models Generated with the Use of Immunodeficient NSG-SGM3 Mice
Authors: Baidyuk Ekaterina Viktorovna , Belotserkovskaya Ekaterina Vasilevna , Girshova L.L. , Golotin V.A. , Levchuk K.A. , Vasyutina M.L. , Portnaya Ya.A. , Shchelina E.V. , Bredneva O.G. , Petukhov A.V. , Zaritskey A.Yu. , Demidov O.N.
Published: December 2021

Background. Up to the present the survival rates of acute myeloid leukemia (AML) patients have remained low. A successful AML management presupposes generating personalized models of the disease. The most promising research activity in this field is creation of AML patient-derived xenograft models using the advanced strain of immunodeficient humanized NSG-SGM3 mice. Aim. To generate AML patient-derived xenograft models using immunodeficient NSG-SGM3 mice. Materials & Methods. The creation of PDX models was based on bone marrow aspirates taken from 4 patients with newly diagnosed AML who were treated at the V.A. Almazov National Medical Research Center. Patient-derived tumor cells were transplanted to NSG-SGM3 mice. Test experiment consisted in injecting AML cells OCI-АМL2 and HL60 in NSG-SGM3 mice. The efficacy of tumor engraftment was evaluated in terms of physical condition of animals and laboratory tests (blood count, blood smear, PCR, and flow cytofluorometry). Results. The engraftment of applied tumor cells derived from AML patients was achieved in half (2 out of 4) of the transplanted tumor samples. In mice with successful transplantation leukocytosis was reported. Blast cells were identified in peripheral blood on Day 30 after transplantation. The mice with injected AML cells OCI-АМL2 and HL60 showed a more aggressive course of disease. Among tested approaches to evaluate tumor engraftment in mouse recipients, the PCR method was marked by highest sensitivity. Conclusion. The use of immunodeficient humanized NSG-SGM3 mice enables successful generation of AML patient-derived xenograft models.
Technical Aspects of Minimal Residual Disease Detection by Multicolor Flow Cytometry in Acute Myeloid Leukemia Patients
Authors: Galtseva I.V. , Davydova Yuliya Olegovna , Kapranov N.M. , Nikiforova K.A. , Parovichnikova E.N.
Published: December 2021

Detection and monitoring of minimal residual disease (MRD) are essential components of programmed therapy. They are crucial for the choice of treatment strategy and for prognostic purposes practically in all hematologic diseases. MRD is often detected by multicolor flow cytometry, the method with fairly high specificity and sensitivity. However, to identify MRD in acute myeloid leukemia patients is one of the most challenging tasks flow cytometry specialists are faced with. Cytometric data analysis requires the expert knowledge of immunophenotype of all maturing bone marrow cells. Besides, MRD analysis in acute myeloid leukemia has not been standardized while approaches suggested by different studies vary considerably. The present paper reports the experience of MRD analysis, demonstrates the gating strategy, immunophenotype description of normal non-tumor hematopoietic cells, and presents some examples of MRD assessment. Additionally, panels of monoclonal antibodies are provided, along with an evaluation of their advantages and disadvantages.
General Cybersecurity Maturity Assessment Model: Best Practice to Achieve Payment Card Industry-Data Security Standard (PCI-DSS) Compliance
Authors: Razikin Khairur , Widodo Agus
Published: December 2021

The use of technology in the era of the Industrial Revolution 4.0 is essential, marked by the use of technology in the economy and business. This situation makes many companies in the payment sector have to improve their information technology security systems. In Indonesia, Bank Indonesia and the Financial Services Authority (Otoritas Jasa Keuangan - OJK) are agencies that provide operational permits for companies by making Payment Card Industry-Data Security Standard (PCI-DSS) certification as one of the requirements for companies to obtain operating permits. However, not all companies can easily get PCI-DSS certification because many companies still do not meet the PCI-DSS requirements. The research offers a methodology for measuring the level of technology and information maturity using general cybersecurity requirements adopted from the cybersecurity frameworks of CIS, NIST, and Cobit. Then, the research also performs qualitative calculations based on interviews, observations, and data surveys conducted on switching companies that have been able to implement and obtain certification. PCI-DSS to produce practical cybersecurity measures, in general, can be used as a measure of the maturity of technology and information security. The results and discussion provide a model assessment tool on the procedures and requirements needed to obtain PCI-DSS certification. The maturity level value of PT XYZ is 4.0667 at maturity level 4, namely quantitatively managed, approaching level 5 as the highest level at maturity level.
Evaluation on User Perception Effect based on Interaction Techniques in the Stereoscopic Environment
Authors: Caesaron Dino , Prasetyo Lukodono Rio , Nugrahaini Safrudin Yunita
Published: December 2021

The interaction of user performance with three-dimensional (3D) objects has become an important issue in the recent development of virtual reality applications. Additionally, the basic conviction of current Virtual Reality (VR) supports the development of the viable interface between humans and machines. The research focuses on the user’s interaction technique by considering two approaches (direct and indirect interaction techniques) for the users while interacting with threedimensional objects. Numerous possible uses can benefit from virtual reality by considering a few fundamental visual and cognitive activities in the Virtual Environment (VE), such as the interpretation of space that users of clear and indirect perception are not well established. The experiment is performed in a stereoscopic environment using a reciprocal tapping task. Participants are expected to use direct pointing as well as indirect cursor techniques to select a stereoscopic spherical target. The results show that, in the sense of a direct interaction technique, user recognition of an object appears to converge in the center of a simulated area. Unfortunately, this convergence is not demonstrated in the indirect cursor situation. The pointing estimation from the users is more accurate when using the indirect interaction approach. The findings provide an understanding of the interaction characteristics done by the users in the stereoscopic environment. Importantly, developers of a virtual environment may use the result when developing effective user interface perception in specific interaction techniques.