bluuebunny/crossref_metadata_2025 huggingface dataset:
Computational exploration of novel ROCK2 inhibitors for cardiovascular disease management; insights from high-throughput virtual screening, molecular docking, DFT and MD simulation
Authors: Ali Iqra , Iqbal Muhammad Nasir , Ibrahim Muhammad , Haq Ihtisham Ul , Alonazi Wadi B. , Siddiqi Abdul Rauf
Published: November 2023

Cardiovascular disorders are the world’s major cause of death nowadays. To treat cardiovascular diseases especially coronary artery diseases and hypertension, researchers found potential ROCK2 (Rho-associated coiled-coil-containing protein kinase 2) target due to its substantial role in NO-cGMP and RhoA/ROCK pathway. Available drugs for ROCK2 are less effective and some of them depict side effects. Therefore, a set of novel compounds were screened that can potentially inhibit the activity of ROCK2 and help to treat cardiovascular diseases by employing In-silico techniques. In this study, we undertook ligand based virtual screening of 50 million compound’s library, to that purpose shape and features (contain functional groups) based pharmacophore query was modelled and validated by Area Under Curve graph (AUC). 2000 best hits were screened for Lipinski’s rule of 5 compliance. Subsequently, these selected compounds were docked into the binding site of ROCK2 to gain insights into the interactions between hit compounds and the target protein. Based on binding affinity and RMSD scores, a final cohort of 15 compounds were chosen which were further refined by pharmacokinetics, ADMET and bioactivity scores. 2 potential hits were screened using density functional theory, revealing remarkable biological and chemical activity. Potential inhibitors (F847-0007 and 9543495) underwent rigorous examination through MD Simulations and MMGBSA analysis, elucidating their stability and strong binding affinities. Results of current study unveil the potential of identified novel hits as promising lead compounds for ROCK2 associated with cardiovascular diseases. These findings will further investigate via In-vitro and In-vivo studies to develop novel druglike molecules against ROCK2.
Population genomics provides insights into the genetic diversity and adaptation of the Pieris rapae in China
Authors: Zheng Linlin , Wang Huan , Lin Junjie , Zhou Yuxun , Xiao Junhua , Li Kai
Published: November 2023

The cabbage white butterfly (Pieris rapae), a major agricultural pest, has become one of the most abundant and destructive butterflies in the world. It is widely distributed in a large variety of climates and terrains of China due to its strong adaptability. To gain insight into the population genetic characteristics of P. rapae in China, we resequenced the genome of 51 individuals from 19 areas throughout China. Using population genomics approaches, a dense variant map of P. rapae was observed, indicating a high level of polymorphism that could result in adaptation to a changing environment. The feature of the genetic structure suggested considerable genetic admixture in different geographical groups. Additionally, our analyses suggest that physical barriers may have played a more important role than geographic distance in driving genetic differentiation. Population history showed the effective population size of P. rapae was greatly affected by global temperature changes, with mild periods (i.e., temperatures warmer than those during glaciation but not excessively hot) leading to an increase in population size. Furthermore, by comparing populations from south and north China, we have identified selected genes related to sensing temperature, growth, neuromodulation and immune response, which may reveal the genetic basis of adaptation to different environments. Our study is the first to illustrate the genetic signatures of P. rapae in China at the population genomic level, providing fundamental knowledge of the genetic diversity and adaptation of P. rapae.
Individual, family, and environmental determinants of vision-related quality of life of children and young people with visual impairment
Authors: Šemrov Ana , Tadić Valerija , Cortina-Borja Mario , Rahi Jugnoo Sangeeta ,   on behalf of The Resilience and Childhood Visual Impairment Study Group
Published: November 2023

Childhood visual impairment can have a significant impact on an individual’s development. To improve clinical care and develop appropriate psychosocial interventions of these patients, it is necessary to understand the contributing and modifiable factors that both identify individuals in greater need and could be targeted in interventions. Here we investigate the broader individual, family, and environmental factors associated with vision-related quality of life (VQoL) of children and young people with visual impairment (CYP-VI). Data for this cross-sectional study were collected from September 2014 to May 2017 to develop and validate two vision-specific patient-reported outcome measures (PROMs) for CYP-VI. Patients were recruited from 22 hospitals in the United Kingdom and were aged 7–18 years with visual impairment as per WHO criteria. Participants self-completed the two PROMs, VQoL and Functional Vision Questionnaires. Clinical characteristics were extracted from medical records. Their carers provided information on family sociodemographic backgrounds. Associations between the VQoL scores and other factors were examined using Spearman’s correlation, Kruskal-Wallis, Wilcoxon rank-sum tests, and quantile regression models. The sample consisted of 152 CYP-VI (67 females). Better VQoL was significantly associated with better functional vision overall (rSpearman= –0.52), parent-reported absence of additional chronic conditions (dCohen= 0.46), attending mainstream (versus other) school (dCohen= 0.44), higher socio-economic status (rSpearman= 0.17) and higher parental education level (rSpearman= 0.20). No other investigated factors were significantly associated with VQoL. The final quantile regression model included functional vision scores and the presence of additional health condition. Variation in self-reported VQoL in CYP-VI can be partly accounted for by factors relating to the clinical status of the affected child and, more importantly, by non-health-related factors. This needs to be considered in clinical practice when assessing vision-specific outcomes and providing support to CYP-VI, as well as in the development of future interventions.
Experiences of mothers and health workers with MomCare and SafeCare bundles in Kenya and Tanzania: A qualitative evaluation
Authors: Izudi Jonathan , Owoko Henry Odero , Bagayoko Moussa , Kadengye Damazo
Published: November 2023

Between 2019 and 2022, the digital dividend project (DDP), a technology-based intervention that combined care (MomCare) and quality improvement (SafeCare) bundles to empower mothers to access quality care during pregnancy, labor, and delivery, and postnatally, was implemented in Kenya and Tanzania aiming to improve maternal and newborn health outcomes. We describe the experiences of the mothers in accessing and utilizing health services under the bundles, and the experiences of the health workers in providing the services. Between November and December 2022, we conducted a qualitative evaluation across health facilities in Kenya and Tanzania. We held Interviews with mothers (pregnant and postpartum women who had benefited from the care bundles) and health workers (physicians, nurses, and midwives who provided the care bundles, including health facility In-Charges) at the antenatal care (ANC), skilled birth attendance (SBA), and postnatal care (PNC) service delivery points. We performed content analysis. Findings are reported using themes and quotes from the participants. We included 127 mothers (Kenya = 76, Tanzania = 51) and 119 health workers. Findings revealed that among mothers, the care bundles eased access to health services, ensured easy access and optimal ANC use, provision of respectful care, removed financial constraints, and led to the receipt of sufficient health education. Health workers reported that the care bundles offered them a new opportunity to provide quality maternal and newborn care and to adhere to the standard of care besides experiencing a positive and fulfilling practice. Health systems improvements included prompt emergency response and continual care, infrastructural developments, medical supplies and logistics, staffing, and increased documentation. Overall, the care bundles led to the strengthening of the healthcare system (staffing, service delivery, financing, supplies/logistics, and information management) in order to deliver quality maternal and child health services. The bundles should be replicated in settings with similar maternal and child health challenges.
Performance evaluation of national healthcare systems in the prevention and treatment of non-communicable diseases in sub-Saharan Africa
Authors: Arhin Kwadwo , Asante-Darko Disraeli
Published: November 2023

Background

Non-communicable diseases (NCDs) remain a major public health concern globally, threatening the achievement of sustainable development goal 3.4 (SDG 3.4), which seeks to reduce premature NCD-related deaths by one-third by 2030. According to the World Health Organization (WHO), improving the efficiency of NCD spending (i.e., maximizing the impact of every dollar spent on NCDs) is one of the strategic approaches for achieving SDG target 3.4. This study aims to assess the efficiency and productivity of NCDs spending in 34 sub-Saharan African (SSA) countries from 2015 to 2019.

Methods

The study employed the data envelopment analysis (DEA) double-bootstrap truncated and Tobit regressions, one-stage stochastic frontier analysis (SFA) model, the Malmquist productivity index (MPI), and spatial autocorrelation analysis to estimate NCDs spending efficiency, identify the context-specific environmental factors that influence NCDs spending efficiency, evaluate total productivity change and identify its components, and assess the spatial interdependence of the efficiency scores.

Results

The estimated average DEA bias-corrected NCD spending efficiency score was 87.3% (95% CI: 86.2–88.5). Additionally, smoking per capita, solid fuel pollution, alcohol use, governance quality, urbanization, GDP per capita, external funding for NCDs, and private domestic funding for NCDs healthcare services were found to be significantly associated with NCDs spending efficiency. The study also revealed a decline of 3.2% in the MPI, driven by a 10.6% technical regress. Although all countries registered growth in efficiency, except for the Central Africa Republic and DR Congo, the growth in efficiency was overshadowed by the decline in technical change. Global Moran’s I test indicated the existence of significant positive spatial autocorrelation in the efficiency of NCDs spending across SSA countries.

Conclusion

The study underscores the importance of efficient use of resources in NCDs treatment and prevention and increased investment in NCDs research and development in achieving the SDG target 3.4.
Non-Test Portfolio Assessment Techniques: Innovation to Improve Maharah Al-Kitabah
Authors: Umam Muhammad Khotibul , Nawangsari Adik Laila Fitri , Firdausah Isyqie
Published: November 2023

Portfolio assessment is an ongoing evaluation based on collecting assignments and information from students to show the progress of competency development over a certain period. The method used in this research is action research, where researchers can be directly involved in improving the quality of lectures, which is reflected in improving students' writing skills. Then the researcher engages in reflection on the problem, collects and analyzes data, and implements changes or an action plan based on the reflection results. The purpose of this study Islam to improve the Arabic writing skills of library science students at UIN Sunan Kalijaga Yogyakarta by using portfolio assessment. The research results show that portfolio assessment innovations can improve the writing skills of Library Science students at UIN Sunan Kalijaga Yogyakarta.
Revitalisasi Idealitas Pengelolaan Keuangan Pendidikan: Studi Masa Khalifah Umar bin Abdul Aziz
Authors: Nurdin Muh Nur Islam , Munastiwi Erni
Published: November 2023

Financial management in education holds a central position in building an effective and sustainable education system. However, during the era of Umar bin Abdul Aziz, it did not receive adequate historical attention. This research aims to evaluate the financial management of education during that period through a descriptive literature study. The results indicate that financial management of education at that time encompassed financial planning, fair salary distribution, infrastructure development, and administrative evaluation such as fund recording. Umar bin Abdul Aziz also promoted values of integrity in governance. A progressive and transformative educational leader is needed for dynamic education policies and optimal financial management. In conclusion, the role of key leaders is crucial in creating a robust and sustainable education system.
Analisis Penerapan Pembelajaran Berbasis Kontekstual (Contextual Teaching and Learning) pada Mata Pelajaran Bahasa Arab
Authors: Triani Triani , Putra Sudarmadi
Published: November 2023

This study aims to describe and analyze Contextual Teaching and Learning (CTL) in Arabic subjects at SMPIT Al-Falaah Simo. This type of research is descriptive with a qualitative approach. The source of information for this research is the head of SMPIT Al-Falaah Simo, Arabic teachers, and students. Data collection techniques are carried out through observation, interviews and documentation. The findings in this study include that: 1. The application of CTL in Arabic subjects at SMPIT Al-Falaah Simo goes through three stages; the preparation stage, the implementation stage, and the evaluation stage. In this application, it has contained seven components of CTL such as constructivism, questioning, inquiry, learning community, modeling, reflection, and authentic assessmen. 2. There are several obstacles in the application of CTL in Arabic subjects at SMPIT Al-Falaah Simo; Teachers have not mastered and understood contextual learning methods comprehensively, limited learning resources, limited time in the context of mentoring students, the situation of teaching and learning activities that teachers create is not always the same from day to day, and limited facilities such as the absence of a language laboratory.
Efektivitas Asesmen Diagnostik dalam Pembelajaran Berdiferensiasi pada Pelajaran Bahasa Indonesia
Authors: Wulandari Gusti Ayu Putu Trisna Wulandari , Putrayasa Ida Bagus , Martha I Nengah
Published: November 2023

Students have very diverse backgrounds, so diagnostic assessments are needed in the practice of learning Indonesian at SMA Negeri 1 Kuta Utara. Diagnostic assessments are divided into two, namely non-cognitive diagnostic assessments and cognitive diagnostic assessments. This study is qualitative descriptive research, namely a research method which has the nature of presenting the reality according to the data obtained with the aim of illustrating how effective diagnostic assessment is in differentiated learning. Diagnostic assessments carried out in differentiated learning in Indonesian Language Lessons at SMA Negeri 1 North Kuta are very effective. After carrying out a diagnostic assessment, teachers can create learning that suits the characteristics, interests and abilities of students, relating to processes, content, products and learning environments. The use of diagnostic assessments can increase students' interest in learning Indonesian, because apart from making it easier to understand the material, learning is also tailored to students' readiness, interests and abilities.
Pendidikan Karakter dalam Tepukan Tiga Kali pada Pembelajaran Bahasa Indonesia di SMP
Authors: Suparmini Harum , Widayati Mukti , Nurnaningsih Nurnaningsih
Published: November 2023

Character education is now necessary for the survival of a nation in the midst of rapid and dramatic social change. This study aims to reveal and describe character education in a collection of short stories by Wicahyanti Rejeki and its relevance in learning Indonesian in junior high school. This research belongs to the category of literary research with a qualitative descriptive form, using a literary sociology approach with the content analysis method. The data used in this research is a collection of short stories Tepukan Tiga Kali by Wicahyanti Rejeki. The data analysis techniques used are dialectical techniques and interactive techniques. The results showed that the first five short stories from the Tepukan Tiga Kali short story collection studied contained character education values. Character education contained in the five short stories include: faith and piety in God Almighty, global diversity, mutual cooperation, independence, critical reasoning, and creativity. Secondly, the character education values contained in the collection of short stories can help achieve the educational objectives of Indonesian language lessons. The implications of moral and character values contained in literary works play a role in developing cognitive, affective, psychomotor aspects, developing personality, and developing the social personality of junior high school students.
A SOLUTION TO THE RIQUIER–NEYMANN PROBLEM FOR POLYHARMONIC EQUATIONS IN A BALL
Authors:   South Ural State University, Chelyabinsk, Russian Federation, Karachik V.V.
Published: November 2023

In this paper, an elementary solution for polyharmonic equations is determined and its properties are given. This elementary solution coincides with previously known elementary solutions of biharmonic and triharmonic equations. Using the elementary solution, an integral representation of the solutions of a non-homogeneous polyharmonic equation in a bounded domain with a smooth boundary is found. Based on the integral representation, the solvability of the Riquier–Neumann problem is investigated. First, the concept of the Green's function of the Riquier–Neumann problem is defined, and then the Green's function is proved. Using the integral representation of the solutions of the polyharmonic equation and the Green's function of the Riquier–Neumann problem, the integral representation of the solution of the Riquier–Neumann problem in a unit ball is found. An example of the solution of the Neumann problem for the Poisson equation with the simplest right-hand side is given, which is necessary in what follows. On the basis of the Green's function of the Riquier–Neumann problem, a theorem on the integral representation of the solution of the Riquier–Neumann boundary value problem with boundary data, the integral of which over the unit sphere vanishes, is proved. In conclusion, on the basis of the theorem, an example of calculating the solution of the Riquier–Neumann problem with boundary functions coinciding with the traces of homogeneous harmonic polynomials on a unit sphere is given.
Origin of Discrete and Continuous Dark Noise in Rod Photoreceptors
Authors: Bocchero Ulisse , Pahlberg Johan
Published: November 2023

The detection of a single photon by a rod photoreceptor is limited by two sources of physiological noise, called discrete and continuous noise. Discrete noise occurs as intermittent current deflections with a waveform very similar to that of the single-photon response to real light and is thought to be produced by spontaneous activation of rhodopsin. Continuous noise occurs as random and continuous fluctuations in outer-segment current and is usually attributed to some intermediate in the phototransduction cascade. To confirm the origin of these noise sources, we have recorded from retinas of mouse lines with rods having reduced levels of rhodopsin, transducin, or phosphodiesterase. We show that the rate of discrete noise is diminished in proportion to the decrease in rhodopsin concentration, and that continuous noise is independent of transducin concentration but clearly elevated when the level of phosphodiesterase is reduced. Our experiments provide new molecular evidence that discrete noise is indeed produced by rhodopsin itself, and that continuous noise is generated by spontaneous activation of phosphodiesterase resulting in random fluctuations in outer-segment current.
Distinct Contributions of the Cerebellum and Basal Ganglia to Arithmetic Procedures
Authors: Saban William , Pinheiro-Chagas Pedro , Borra Sravya , Ivry Richard B.
Published: November 2023

Humans exhibit complex mathematical skills attributed to the exceptional enlargement of neocortical regions throughout evolution. In the current work, we initiated a novel exploration of the ancient subcortical neural network essential for mathematical cognition. Using a neuropsychological approach, we report that degeneration of two subcortical structures, the cerebellum and basal ganglia, impairs performance in symbolic arithmetic. We identify distinct computational impairments in male and female participants with cerebellar degeneration (CD) or Parkinson's disease (PD). The CD group exhibited a disproportionate cost when the arithmetic sum increased, suggesting that the cerebellum is critical for iterative procedures required for calculations. The PD group showed a disproportionate cost for equations with increasing addends, suggesting that the basal ganglia are critical for chaining multiple operations. In Experiment 2, the two patient groups exhibited intact practice gains for repeated equations at odds with an alternative hypothesis that these impairments were related to memory retrieval. Notably, we discuss how the counting and chaining operations relate to cerebellar and basal ganglia function in other task domains (e.g., motor processes). Overall, we provide a novel perspective on how the cerebellum and basal ganglia contribute to symbolic arithmetic. Our studies demonstrate the constraints on the computational role of two subcortical regions in higher cognition.
Training-Dependent Gradients of Timescales of Neural Dynamics in the Primate Prefrontal Cortex and Their Contributions to Working Memory
Authors: Trepka Ethan , Spitmaan Mehran , Qi Xue-Lian , Constantinidis Christos , Soltani Alireza
Published: November 2023

Cortical neurons exhibit multiple timescales related to dynamics of spontaneous fluctuations (intrinsic timescales) and response to task events (seasonal timescales) in addition to selectivity to task-relevant signals. These timescales increase systematically across the cortical hierarchy, for example, from parietal to prefrontal and cingulate cortex, pointing to their role in cortical computations. It is currently unknown whether these timescales are inherent properties of neurons and/or depend on training in a specific task and if the latter, how their modulations contribute to task performance. To address these questions, we analyzed single-cell recordings within five subregions of the prefrontal cortex (PFC) of male macaques before and after training on a working-memory task. We found fine-grained but opposite gradients of intrinsic and seasonal timescales that mainly appeared after training. Intrinsic timescales decreased whereas seasonal timescales increased from posterior to anterior subregions within both dorsal and ventral PFC. Moreover, training was accompanied by increases in proportions of neurons that exhibited intrinsic and seasonal timescales. These effects were comparable to the emergence of response selectivity due to training. Finally, task selectivity accompanied opposite neural dynamics such that neurons with task-relevant selectivity exhibited longer intrinsic and shorter seasonal timescales. Notably, neurons with longer intrinsic and shorter seasonal timescales exhibited superior population-level coding, but these advantages extended to the delay period mainly after training. Together, our results provide evidence for plastic, fine-grained gradients of timescales within PFC that can influence both single-cell and population coding, pointing to the importance of these timescales in understanding cognition.
No los confundimos con dioses
Authors: Díaz Monsalvo Lourdes María
Published: November 2023

La investigación del investigador de Oxford, David Grimes, llamada “Demasiados minions arruinan la trama” analiza la viabilidad de las creencias conspirativas, buscando demostrar que no es posible mentir en una escala. Sin embargo, ninguna de las variables incluidas versa sobre el poder económico de quien miente, ni de la vulnerabilidad de quien recibe la afectación de la mentira. Este artículo se justifica en la creencia (aún viva) de que los pueblos nativos americanos confundieron a los conquistadores españoles con dioses; asunto que ha servido de base para desmerecer el desarrollo de los primeros habitantes y su sabiduría ancestral. La forma en que este ensayo busca debatir esa ecuación es haciendo un recorrido por los dioses que tenían en cada territorio americano, mostrando la imposibilidad de que aquellos fueran confundidos con españoles que llegaban en barcos. Solo poner el foco en la brecha del poder del esclavizador y su tradición escrita será lo que pueda hacer que se superen las mentiras generalizadas repetidas de generación en generación para promover el poderío blanco y la autodiscriminación en estos pueblos. Así, cuando se analiza la capacidad de que una mentira sea sostenida en el tiempo, necesariamente hay que estudiar a quién le conviene, qué tan grande es su poder y a quién aplasta –y cuán pequeño es su poder–.
Water Sustainability Initiatives to Meet the Water Crisis in India
Authors: Jena Madhab C. , Mishra Sarat K. , Moharana Himanshu S.
Published: November 2023

One of the most pressing global challenges we face today is the rapid growth of the population. As the population continues to expand, the need for rapid industrialization has become paramount. However, this industrialization and urbanization have given rise to a significant and detrimental consequence: environmental pollution. This pollution, in turn, has led to various crises, including those related to water, food, and air quality. Water, being an essential element for human existence, is of utmost importance. Without access to clean and sufficient water, life on Earth would be unsustainable. Unfortunately, India has been grappling with a prominent water crisis, particularly during the summer seasons, resulting in the loss of countless lives each year. Even during other seasons, the availability of water is often satisfactory, but the quality of water remains a concern in many parts of the country. The shortage of water can be attributed primarily to the declining levels of underground water and the ever-increasing demand for this precious resource. India receives ample rainfall during the monsoon season; however, a significant portion of this water flows into the oceans, causing floods in various regions. Conversely, during the summer months, the scarcity of water leads to droughts in many areas. Therefore, it is imperative to initiate sustainable water management practices, including rainwater harvesting, to address this water crisis. This review article delves into various types of water sustainability initiatives with a structured approach and analyzes the associated challenges. Additionally, it proposes detailed systems that can be implemented to enhance water availability and distribution throughout the country. These measures are crucial steps toward mitigating the water crisis and ensuring a sustainable water future for India.
Nurodymai autoriams
Authors: T. 17 Lietuvos chirurgija
Published: November 2023

[text in English and Lithuanian]
Coping Factors for Caregivers of Children With Medical Complexity During Hospitalization
Authors: Krieg Kathleen D. , Nooraie Reza Yousefi , Favella Maria , Iadarola Suzannah , Kuo Dennis Z. , O’Connor Thomas G. , Petrenko Christie L.M. , Bayer Nathaniel D.
Published: November 2023

OBJECTIVES

This study aimed to identify coping factors for caregivers of children with medical complexity (CMC) to manage the stressors and experience associated with their child’s hospitalization.

METHODS

We conducted semistructured interviews with CMC caregivers over a video-conferencing platform to examine factors that they perceive impact their coping while their children are hospitalized. Interviews were audio-recorded, transcribed, and imported into a qualitative coding software (MAXQDA). Using a modified grounded theory approach, we assigned process and in vivo codes to the transcripts and conducted interpretive analysis to identify themes. Once we reached thematic saturation, we finalized themes by discussing them to achieve group consensus and processed themes through triangulation with our institution’s pediatric family advisory council.

RESULTS

We interviewed 14 caregivers (11 mothers and 3 fathers) and identified 3 major themes. The factors that contributed to CMC caregiver coping with their child’s hospitalizations included caregivers: feeling that they are prioritizing their child’s needs over their own, feeling trust in their child’s interdisciplinary healthcare team, and feeling their self-care practices are well adjusted to the hospital setting.

CONCLUSIONS

Our study found 3 coping factors for caregivers of CMC during their child’s hospitalization. Development and testing of interventions that enhance these coping practices may better support CMC caregivers during their child’s hospitalizations. Potential interventions could include developing structured processes to establish caregiver involvement in their child’s hospital care and helping caregivers modify their existing coping mechanisms to the hospital setting.
Increasing Access to and Utilization of Behavioral Health Care Through Integrated Primary Care
Authors: Hostutler Cody , Wolf Noelle , Snider Tyanna , Butz Catherine , Kemper Alex R. , Butter Eric
Published: November 2023

OBJECTIVES

To evaluate changes in access to and utilization of behavioral health (BH) services after the integration of psychologists into primary care clinics compared with clinics without integrated psychologists.

METHODS

We integrated 4 of 12 primary care clinics within our academic health system. We used the median wait time for BH services as a proxy for changes in access and defined BH utilization as the percentage of primary care visits that resulted in contact with a BH clinician within 180 days. We compared changes in access and utilization from the year before integration (September 2015 to September 2016) with the 2 years after integration (October 2016 to October 2018) within integrated clinics and between integrated and nonintegrated clinics. We used difference-in-difference analysis to test the association of study outcomes with the presence of integrated psychologists.

RESULTS

Access and utilization were similar across all practices before integration. After integration, BH utilization increased by 143% in integrated clinics compared with 12% in nonintegrated clinics. The utilization of BH services outside of the medical home (ie, specialty BH service) decreased for integrated clinics only. In clinics with integrated psychologists, 93% of initial BH visits happened on the same day as a need was identified. The median wait time for the 7% in integrated clinics who were not seen on the same day was 11.4 days (interquartile range = 5.3–17.7) compared with 48.3 days (interquartile range = 20.4–93.6) for nonintegrated clinics.

CONCLUSIONS

A team-based integration model increased BH utilization and access.
A função materna nos contos de fadas
Authors: Sena Fabiana , Marques Formiga Girlene , Da Silva Joselí Maria
Published: November 2023

Este artigo tem a pretensão de atentar sobre alguns aspectos latentes em contos de fadas, nas versões produzidas pelos Irmãos Grimm e por Charles Perrault, e vistos sob a perspectiva da Psicanálise, na leitura de Bruno Bettelheim (1980). Fareos uma análise de alguns dos contos dos autores acima, sob o olhar de Bettelheim, o qual, seguindo os passos das teorias freudiana e lacaniana, investe no Complexo de Édipo, para relacionar as três fases desse complexo, manifestadas nas personagens de “Branca de Neve”, “Cinderela”, “Príncipe Sapo”, “A Moça dos Gansos”, “João e Maria”, “As Fadas”, “Rapunzel”, “Pequeno Polegar” e “Chapeuzinho Vermelho”. Trata-se de uma análise bibliográfica, cujo objetivo é o de permitir uma reflexão sobre a possível identificação das crianças com as personagens desses contos, de modo a lhes facilitar sua imersão no mundo, a partir das informações inscritas, segundo Lacan, no Imaginário, no Simbólico e no Real, estruturas que, além de não desprezarem os conceitos freudianos, conseguem ampliá-los.
A Floristical and Ecological Study of the Medicinal Flora Used by the Local Population of the Haouz-Rehamna Region (Middle Atlantic Morocco-4)
Authors: Benkhnigue O. , Chaachouay N. , Zidane L.
Published: November 2023

To carry out a floristical inventory of plants used in traditional medicine in the HaouzRehamna region, a series of ethnobotanical surveys were conducted during five campaigns (2012–2017) with a representative sample of 1,700 people. These researches are completed by the determination of species collected in the field. It is worth mentioning that, taking into account the recent changes at the international level on taxonomy, the results obtained allowed us to elaborate a catalogue of 415 plant species (bryophytes (2 species); lichens (1), superior mushrooms (1), pteridophytes (4), gymnosperms (8), chlamydosperms (2) and angiosperms (397)) belonging to 291 genera and 99 botanical families, of which nine are the most representative and total 53.49%, namely: Asteraceae (11.33%), Lamiaceae (10.12%), Fabaceae (8.43%), Apiaceae (6.50%), Solanaceae (4.34%), Poaceae (3.86%), Rosaceae (3.37%), Brassicaceae (3.13%) and Cucurbitaceae (2.41%). On the contrary, the other 90 families represent a specific number less than or equal to 1.93%. The data also reflect a high degree of monotypic, where a single species represented 47.48% of the recorded families, and 79.03% of the genera were monotypic. The spontaneous plants occupy the first place with 241 species (58.07%). In addition, the classification by genus showed that the genus Mentha is the most used by its number of species (8 species). Moreover, we noted the use of 12 hybrid species. The chorological analysis revealed the domination of taxa with Mediterranean distribution for spontaneous species. Therophytes (27%) and phanerophytes (23.36%) are the most represented life forms. The results of this study could serve as a basis for future research in the field of floristics and ecology for the conservation of biodiversity.
Proton-conducting oxides based on LaScO3: structure, properties and electrochemical applications. A focus review
Authors:   Institute of High–Temperature Electrochemistry, Antonova Ekaterina P.
Published: November 2023

Solid state proton conductors are promising materials for various electrochemical applications. LaScO3 - based oxides are representatives of the proton-conducting oxides with perovskite structure, alternative to conventional cerates and zirconates of alkaline-earth elements. These oxides exhibit a sufficient level of proton conductivity with a combination of good chemical stability in the H2O and CO2 - containing atmospheres. The current review is focused on summarizing and analyzing of the currently available data on LaScO3 - based oxides. The peculiarities of crystal structure and proton defect formation, aspects of synthesis and obtaining dense ceramics, and electrical properties are provided. Additionally, the current state of applications in electrochemical devices of LaScO3 - based oxides is briefly discussed.
Educação linguística no Brasil à luz das políticas e dos direitos linguísticos
Authors: Simões Pedro
Published: November 2023

Neste texto, problematizamos a educação linguística no Brasil na ótica das políticas e dos direitos linguísticos. Viso provocar pesquisadores, particularmente aqueles que se voltam para Bakhtin e o Círculo e para a educação linguística no Brasil, a pensar, de um lado, a produtividade de se pensar a fenomenologia de Bakhtin e sua teoria do diálogo à luz do que podemos conceber como perspectiva de estudos em direitos e políticas linguísticas; e pensar, em confluência, de que forma é possível situar a prática da educação linguística, no Brasil, a partir de uma perspectiva de direitos e políticas linguísticas assumida por lentes do pensamento de Bakhtin e o Círculo.
Landscape evaluation of a residential plant community based on the scenic beauty estimation method
Authors: Liu Shuang , Sun Yudan , Ouyang Haofeng , Feng Shuyi
Published: November 2023

In Wenzhou City, located in Zhejiang Province, 100 plant communities were selected as evaluation samples, and the scenic beauty estimation (SBE) method was used to evaluate the degree of beauty. The semantic difference (SD) analysis method was selected to evaluate landscape characteristics. In the SBE method, plant growth, sense of hierarchy, landscape diversity and colour richness were used as the evaluation factors. A total of 140 professional and non-professional groups evaluated the 100 landscape samples. In the SD method, ten adjective pairs were selected as the evaluation criteria for the landscape features in the study. This research indicates that the SBE values of the professional and non-professional groups are strongly correlated. The non-professional group is more volatile and unstable. Professional evaluations of the plant community’s aesthetic value typically include considerations of elements such as plant growth, hierarchy, diversity of landscape and colour richness. In the evaluation of the landscape diversity, hierarchy, colour richness and plant growth, through the SD landscape analysis, the evaluators were able to conduct a correlation analysis of the landscape characteristics and quality of the green plant landscape. This is to find out what landscape features have the most significant impact on landscape quality.
The order Flavobacteriales: ecological features and clinical signifi-cance in the development of human pathology: review
Authors:   Saratov National Research State University named after N.G. Chernyshevsky, Zubova Ksenia V.
Published: November 2023

The article presents an overview of some representatives of the order Flavobacteriales, in particular clinically significant members of the family Weeksellaceae. Morphological, cultural, and biochemical properties of species important for medicine and biology, namely Chryseobacterium, Elizabethkingia, and Empedobacter, are described. Several physiological features are highlighted. Some data on the phylogeny of these organisms are given. Ecological characteristics are considered, and information about some pathogenic species for humans and animals is presented. Also, literature data on resistance to currently available antimicrobial drugs are given. Clinical cases of infections with bacteria of the genera Chryseobacterium, Elizabethkingia, and Empedobacter, features of the diseases caused, and data on the frequency of infections with these microorganisms are reported. Based on the analyzed data, it has been revealed that species belonging to the order Flavobacteriales may pose a risk to immunocompromised people, to patients with chronic diseases such as cystic fibrosis and oncology, and to infants and the elderly. It has been established that representatives of the order cause nosocomial infections. It has been also found that clinically significant species have intrinsic resistance to a wide range of antimicrobials, and therefore the selection of etiotropic therapy is difficult.
Hormonal and bacterial regulation of innate lymphoid cells phenotypic changes in multiple sclerosis patients and healthy donors
Authors:   Perm Federal Research Center UB RAS, Nekrasova Irina V. , Glebezdina Natal’ya S. ,   Perm Federal Research Center UB RAS, Maslennikova Irina L. ,   Perm Federal Research Center UB RAS, Danchenko Irina Yu. ,   E.A. Vagner Perm State Medical University, Shirshev Sergey V. ,   Perm Federal Research Center UB RAS
Published: November 2023

Multiple sclerosis (MS) is an autoimmune neurodegenerative disease in which the immune system attacks myelin basic protein of nerve axons. Recently, there has been growing interest in studying the role of a newly described population of innate immunity cells – innate lymphoid cells (ILCs) in the pathogenesis of the disease. At the same time, it was found that during pregnancy there is a weakening of Th1-mediated autoimmune pathologies manifestations, including MS. In this work, we studied phenotypic characteristics of ILC cells in MS patients in comparison with healthy donors after 48 h incubation with pregnancy hormone estriol (E3) and commensal microflora cells. To activate ILC, strains of Ecsherichia coli K12 and Lactobacillus plantarum 8R-A3 were used. ILC phenotype was assessed by flow cytometry using monoclonal antibody staining. It has been established that E3 and bacterial factors are able to regulate the maturation of ILC subtypes in different ways. In particular, MS patients’ cells are more susceptible to hormonal modulation, while those of healthy donors are more susceptible to bacterial modulation. In general, the studied factors influence the phenotypic changes in ILC cells, leading to the transition from one type to another, both in healthy donors and in MS.
Typical Situational-version Features of the Initial Stage of Investigating Unlawful Impact on Critical Information Infrastructure: Criminal Law and Criminalistic Aspects
Authors: Stepanenko Diana , Garmyshev Yaroslav
Published: November 2023

The authors examine the questions of ensuring national security on the basis of incorporating modern trends of the digitization of society into the classical approach when investigating criminal cases connected with unlawful impact on critical information infrastructure. Using the situational approach, clauses of criminal legislation and the theory of crime qualification, the authors determine the circumstances included in the subject of proof for the criminal cases of unlawful influence on critical information infrastructure, which serves as a foundation for building general and specific criminalistic versions, and is also the basic scheme for making plans during the preliminary investigation. The authors conclude that, in order to obtain a realistic picture, it is necessary and unavoidable that an aggregate of official criminalistic techniques and scientific approaches should be used to study criminal activities in the sphere of information systems. They stress the necessity of studying and incorporating various data of criminal law research into modern investigative practice. The dominant features of the initial stage are identified, which make it possible to formulate its key tasks. The description of the tasks at this stage predetermines its key functions — the search and cognitive work of investigators and the subjects of investigation they interact with, the use of expert knowledge, the leading role of investigative, operative search versions and expert versions. The specific character of information and search for it predetermine the dominance of search, communicative and experimental investigative actions in the structure of the investigation. The analysis of the specific features of carrying out procedural and other actions at the initial stage of investigation allowed the authors to make conclusions about the importance of using tactical complexes in the investigation. They specify a complex of criminalistic recommendations of technical, tactical and methodological character to be implemented in the practice of crime investigation with the purpose of optimizing the counteraction to unlawful impact on critical information infrastructure.
Criminology and History: Towards Interdisciplinary Convergence
Authors: Pudovochkin Yuri , Babaev Mikhail
Published: November 2023

The connection between criminology and other sciences has always been viewed as a vital component of increasing scientific knowledge on crime and developing the methodology of criminological research. One of the areas of such connection is the interaction between criminology and history. Both sciences are moving towards each other. The principle of historicism, being an inalienable element of the methodology of modern criminology, stimulated criminologists to study the history of crime and its specific types, the history of preventive and law enforcement work, the history of criminological theories’ development. The diversification of the methodological basis for the historical science and the development of social history, in their turn, also turned the attention of historians to the problems of crime and its prevention. Meanwhile, the application of historical method in criminology and the inclusion of crime in the object of historical studies remain two relatively independent and unconnected processes. At the same time, the theoretical understanding of inter-disciplinary connections between criminology and history unjustifiably remains «a white spot». This is not a problem specific of Russia, in recent years it has been the object of attention for specialists all over the world. English-language research explains the absence of cooperation between criminology and history primarily though the goals and the organization of research. Historians study the past for the sake of uncovering the past itself, without stressing its connection to the present, while criminologists, on the contrary, are focused on the present and refer to the past only in the degree necessary for explaining the processes happening today. However, this autonomy, arising from the boundaries that are in many aspects artificial, is duly challenged. Research is consistently moving towards overcoming the isolation of criminology and history. The result of this shift is the development of historical criminology as a special approach to studying crimes and related problems. Special monographs, cooperative group discussions, theme-based issues of authoritative journals, the development of special educational programs are all aimed at ensuring the full-scale inclusion of the historical component in the science of criminology by stimulating historical thinking and abolition of no longer relevant historical-philosophical ideas on the interconnection between the past, the present and the future.
Criminological Portrait of a Person Occupying the Highest Position in the Criminal Hierarchy: Based on the Analysis of Verdicts that Entered Into Force Under Part 4, Article 210 and Article 210.1 of the Criminal Code of the Russian Federation
Authors: Morozov Alexey
Published: November 2023

The topic of the presented research is the features of the subject of crime under Part 4, Art. 210 and Art. 210.1 of the Criminal Code of the Russian Federation (person occupying the highest position in the criminal hierarchy). The research is based on the analysis of all guilty verdicts that entered into force and are executed by the institutions of the penal system under Part 4, Art. 210 of the CC of the RF and Art. 210.1 of the CC of the RF. The goal of the research consisted in identifying the currently relevant characteristics of criminal leaders, which are supported by the law enforcement materials rather than sociological studies, i.e. the characteristics of persons occupying the highest positions in the criminal hierarchy de-jure, and not de-facto. The research used the methods of analysis, synthesis, the formal legal method, and the statistical method. As a result, the author identified the currently relevant characteristics of persons occupying the highest positions in the criminal hierarchy, and pointed out how they changed due to the transformations of the criminal subculture’s norms. The obtained results can be used when studying (teaching) the discipline «Criminal Subculture», in the practical work of bodies of investigation when qualifying crimes under Part 4, Art. 210 of the CC of the RF and Art. 210.1 of the CC of the RF, and in the practice of penitentiary institutions to prevent crimes among persons on preventive registration for being leaders and active participants of dangerous groups. It is concluded that the criminological characteristics of a person occupying the highest position in the criminal hierarchy have undergone considerable changes: certain features that were taboo in the past (having a family, children, official residence registration, military service registration, official job, etc.) are no longer relevant.