bluuebunny/crossref_metadata_2025 huggingface dataset:
Abstract IA007: Regulation of metastasis efficiency via mitochondrial genetics
Authors: Welch Danny R.
Published: January 2023

While there has been increasing appreciation for the roles of mitochondria in cancer, most efforts investigating the genetics of cellular functions study only the nuclear genome. To overcome technical complications of studying the specific contributions of mitochondrial genetics, we created mitochondrial nuclear exchange (MNX) mice by transferring an oocyte nucleus from strain-x into an enucleated oocyte from strain-y. Using MNX mice, we made the following discoveries demonstrating the profound role(s) of mtDNA on several complex phenotypes. - Crossing nuclear genome-matched female mice with male transgenic mice bearing oncogenes, tumorigenicity and metastasis were up- or down-regulated depending upon mtDNA. - MNX mice exhibit different autochthonous tumor formation. - When syngeneic (i.e., histocompatible) mammary and melanoma cells were injected into MNX mice, metastasis changed 3-5X, depending on mtDNA SNP. C57BL/6J mtDNA inhibited metastasis while C3H/HeN mtDNA increased metastasis. - MNX mice have selectively altered epigenetic marks (DNA methylation and histone marks) in the nuclear genome. - MNX mice with higher ROS form more metastases. Scavenging ROS reduced metastasis. - Baseline immune profiles differ in MNX mice compared to nDNA-matched counterparts and polarization states of myeloid populations infiltrating lung metastases were also significantly different. - Metabolomic profiling of >5000 metabolites showed minor differences, none of which appear to correlate with the above-referenced phenotypic changes. - MNX mice have distinct gut microbiota than matched wild-type strains, suggesting mitochondrial-bacterial communication. Together, these results demonstrate that mitochondrial genes are among metastatic quantitative trait loci by intrinsic and extrinsic mechanisms. Candidate signals from mitochondria to the nucleus or bacteria will be reported. And since mitochondrial SNP are markers of genetic ancestry, our findings also suggest that mtDNA SNP could serve as prognostic biomarkers and partially explain racial disparities in disease severity. Support: Susan G. Komen for the Cure (SAC11037), METAvivor Research & Support Inc., National Foundation for Cancer Research, National Cancer Institute P30-CA168524.

Citation Format: Danny R. Welch. Regulation of metastasis efficiency via mitochondrial genetics [abstract]. In: Proceedings of the AACR Special Conference: Cancer Metastasis; 2022 Nov 14-17; Portland, OR. Philadelphia (PA): AACR; Cancer Res 2022;83(2 Suppl_2):Abstract nr IA007.
Abstract IA017: The elusive ‘metastasis driver’: Is it hiding in plain sight
Authors: Stanger Ben
Published: January 2023

Recurrent single nucleotide mutations are a common feature of primary tumor evolution, where mutations in genes such as KRAS, APC, TP53, and BRAF are important drivers of malignancy. Efforts to identify comparable mutations that are exclusive to metastatic lesions - so-called 'metastasis drivers' - have been harder to find. However, the search for such metastasis-enabling genetic events has largely been limited to single nucleotide variants rather than chromosomal alterations (copy number gains and losses), which are far more common in advanced tumors. In this study, we used a stochastic mouse model of pancreatic cancer which gives rise to both highly metastatic and poorly metastatic tumors to interrogate the molecular correlates of metastatic heterogeneity. Our analysis revealed that focal amplifications of the MYC oncogene, but not other oncogenic drivers, were associated with the highly metastatic phenotype. Moreover, highly metastatic tumors exhibited elevated levels of MYC protein and greater expression of MYC target genes. This relationship between MYC copy number and metastasis was also observed in human samples, where MYC amplifications were found in 11% of metastases but fewer than 2% of primary tumors. Mechanistically, MYC enhances metastasis by recruiting pro-invasive macrophages, leading to greater vascular intravasation of tumor cells. These results nominate MYC as a bona fide metastasis driver gene and highlight the importance of considering copy number alterations in the evaluation of genetic mediators of metastasis.

Citation Format: Ben Stanger. The elusive ‘metastasis driver’: Is it hiding in plain sight [abstract]. In: Proceedings of the AACR Special Conference: Cancer Metastasis; 2022 Nov 14-17; Portland, OR. Philadelphia (PA): AACR; Cancer Res 2022;83(2 Suppl_2):Abstract nr IA017.
Abstract IA019: Unique features and dependencies of brain metastases
Authors: Davies Michael A.
Published: January 2023

Metastasis to the central nervous system (CNS), including the brain and leptomeninges, is one of the most common and devastating complications of metastatic melanoma. Metastasis to the brain is detected in 40-60% of stage IV melanoma patients. CNS metastasis remains a leading cause of morbidity and mortality from this disease, and a common site of therapeutic resistance. Improving outcomes in these patients is made challenging by the relatively limited understanding of the features of these tumors- and exacerbated by the frequent exclusion of patients with brain metastases from clinical trials. There is growing evidence that brain metastases from melanoma and other cancers harbor/share unique features that drive the aggressive nature and therapeutic resistance of these tumors. Studies across cancer types have revealed differences in the immune microenvironment of the tumors, as well as their oncogenic mutations and activation of key signaling pathways. Recently, multiple laboratories have identified unique metabolic features of these tumors. Several of these studies have identified novel metabolic dependencies of brain metastases- and suggest a novel paradigm of therapeutic agents (and clinical trials) that are expected to achieve greater benefit in patients with CNS involvement than without. Such findings are leading to the development of both clinics and clinical trials focused on brain metastases across cancer types. They are also leading to further investigations to determine the role of these features in the initiation, progression, and resistance of brain metastases.

Citation Format: Michael A. Davies. Unique features and dependencies of brain metastases [abstract]. In: Proceedings of the AACR Special Conference: Cancer Metastasis; 2022 Nov 14-17; Portland, OR. Philadelphia (PA): AACR; Cancer Res 2022;83(2 Suppl_2):Abstract nr IA019.
Abstract PR003: OXPHOS impairing mitochondrial DNA mutations suppress melanoma growth and metastatic progression
Authors: Shelton Spencer , House Sara , Ramesh Vijayashree , Chen Zhengkang , Llamas Claire , Tasdogan Alpaslan , DeBerardinis Ralph , Morrison Sean , Mishra Prashant
Published: January 2023

Cancers acquire somatic mitochondrial DNA (mtDNA) mutations undetected in surrounding tissues. Cancer-specific mtDNA mutations primarily constitute variants of unknown significance whose oncogenic consequences are poorly understood. Analysis of large-scale sequencing datasets suggests that human cancers generally select against severe mtDNA mutations; however, the presence of selective pressure on the mtDNA genome has yet to be experimentally demonstrated. Here we optimized a FACS-based protocol to reconstitute the highly metastatic human melanoma cell line A375 with exogenous mtDNA, thereby generating nuclear-isogenic cytoplasmic hybrid (cybrid) lines. Homoplasmic cybrids were generated exclusively harboring either exogenous wildtype mtDNA, mtDNA with partial loss of OXHPHOS function (SNPs in mt.ND1 (of Complex I) or mt.ATP6 (of Complex V)), or mtDNA with complete loss of OXPHOS function (derived from a human melanoma harboring a truncating frameshift mutation in mt.CO1 (of Complex IV)). Compared to wildtype cybrids, subcutaneous xenografts of ND1 and ATP6 cybrids into NOD–SCID Il2rg−/− (NSG) mice had elevated primary tumor ROS levels and similar primary tumor growth rates. Xenografts of our most dysfunctional OXPHOS cybrid, CO1, formed tumors albeit with lowered growth rates. Uniquely, the ND1 and CO1 xenografts respectively exhibited diminished metastatic burden and no metastatic burden. Our results suggest that OXPHOS impairing mtDNA mutations are tolerable during primary tumor growth but reduce the severity and incidence of metastasis. Lastly, we generated heteroplasmic A375 cybrids, harboring both wild-type and mutant alleles, and developed a ddPCR method to characterize allelic frequency with single-cell precision. Extended in vitro passage of the heteroplasmic cybrids failed to significantly shift the heteroplasmic mtDNA allelic frequency. However, following subcutaneous xenografting of the heteroplasmic cybrids, primary tumors significantly shifted their variant allele frequency to favor the wildtype allele. In summary, these results indicate that a functional mtDNA haplotype is not absolutely required for tumorigenesis but contributes to metastatic efficiency. In addition, we experimentally demonstrated the existence of selective pressure in favor of functional mtDNA during tumorigenesis.

Citation Format: Spencer Shelton, Sara House, Vijayashree Ramesh, Zhengkang Chen, Claire Llamas, Alpaslan Tasdogan, Ralph DeBerardinis, Sean Morrison, Prashant Mishra. OXPHOS impairing mitochondrial DNA mutations suppress melanoma growth and metastatic progression [abstract]. In: Proceedings of the AACR Special Conference: Cancer Metastasis; 2022 Nov 14-17; Portland, OR. Philadelphia (PA): AACR; Cancer Res 2022;83(2 Suppl_2):Abstract nr PR003.
Abstract PR010: Multiplex imaging reveals features of organotropism in pancreatic ductal adenocarcinoma
Authors: Eng Jennifer , Link Jason , Pelz Carl , Sears Rosalie
Published: January 2023

PDAC patients have a dismal prognosis with an 11% 5-year survival rate, driven in part by the fact that 90% of patients are diagnosed with metastatic disease. In a cohort of 300 PDAC patients, we observed that patients who had lung-only metastasis had longer overall survival than the majority of patients with metastasis to the liver. We used gene expression data to develop a signature based on gene expression in primary tumors of liver versus lung organotropism, which we called pORG. Our pORG signature predicts long term survival in PDAC patients and reveals unique features of the primary tumor, including increased interferon and immune activity in lung tropic tumors and increased proliferation and replication stress in liver-tropic tumors. To validate our findings, we generated cyclic immunofluorescence multiplex imaging data for a subset of 34 patients. Single cell image analysis revealed B and T cell infiltration and spatial clustering in low pORG/ lung tropic tumors, and markers of replication stress in high pORG patients. Our work suggests unique targetable tumor and microenvironment features linked to organotropism in PDAC.

Citation Format: Jennifer Eng, Jason Link, Carl Pelz, Rosalie Sears. Multiplex imaging reveals features of organotropism in pancreatic ductal adenocarcinoma [abstract]. In: Proceedings of the AACR Special Conference: Cancer Metastasis; 2022 Nov 14-17; Portland, OR. Philadelphia (PA): AACR; Cancer Res 2022;83(2 Suppl_2):Abstract nr PR010.
Indirect Vocal Therapy as a Treatment Program for Behavioral Dysphonia: A Pilot Study
Authors: Antonetti-Carvalho Angélica Emygdio , Victor Jhonatan da Silva , Brasolotto Alcione Ghedini , Silverio Kelly Cristina Alves
Published: January 2023

Introduction: Indirect vocal therapy (IVT) has tools that aim to modify an individual’s behavior, emotional factors, and physical environment for restoring vocal quality. Then, vocal health guidance may promote the desire for caring about the voice and prevent or treat behavioral dysphonia. However, studies that used parts of IVT have shown conflicting results. Hence, the main objective of this study was to introduce an IVT program based on the taxonomy of Van Stan et al. [Am J Speech Lang Pathol. 2015;24(2):101–25]. The second objective of this study was to analyze the preliminary effects of the IVT program on vocal comfort through the self-assessment of vocal fatigue, vocal symptoms, vocal handicap, and vocal quality in patients diagnosed with behavioral dysphonia. Method: This is an experimental, analytical, and prospective pilot study. Nine participants (five women; four men) aged between 18 and 50 years with behavioral dysphonia participated in this study. They underwent the IVT program with guidance about vocal health, general health, emotional factors, and motivation. The therapy was implemented twice per week, totalizing eight sessions, each lasting 35 min. Participants were assessed before therapy started (M1), after it ended (M2), and 1 month after as a follow-up (M3). As assessment, participants filled in the Vocal Fatigue Index (VFI), Voice Symptoms Scale (VoiSS), and Vocal Handicap Index-30 (VHI-30). Additionally, they had their voices recorded for acoustic measures (i.e., cepstral peak prominence-smoothed, alpha ratio, and L1-L0) and auditory-perceptual analysis using the GRBASI scale. Results: The acoustic measures and auditory-perceptual analysis showed no significant differences between the assessment moments. The auditory-perceptual analysis showed a mild deviation in participants’ vocal quality. The participants’ scores of the VFI, VoiSS, and VHI were lower in M2 and remained lower in M3. Conclusion: The IVT program had positive results in voice-related self-assessment and vocal comfort. However, further studies are necessary to elucidate its effects on the vocal quality of participants with behavioral dysphonia.
A Ilha de Calor Urbana em ambiente tropical: a Região Metropolitana da Grande Vitória no Brasil
Authors: Correa Wesley de Souza Campos , Aylas Georgynio Y. Rosales , Santiago Alexandre Magalhães , Silva Maria Elisa Siqueira , Vale Cláudia Câmara do , Silva Carlos Batista da , Patucci Natália Nunes
Published: January 2023

Localizada em latitudes tropicais, a Região Metropolitana da Grande Vitória (RMGV), no estado do Espírito Santo, Brasil, é uma importante área para se debater o fenômeno da Ilha de Calor Urbana (ICU). Neste estudo, analisa-se a ocorrência da ilha de calor na RMGV no período de março de 2017 a janeiro de 2018. Os dados horários de temperatura do ar utilizados na análise e discussão dos resultados foram obtidos de cinco estações meteorológicas controladas pelo INMET, IEMA e INFRAERO. Os resultados mostram a existência de ICU na RMGV durante todo o período analisado. As intensidades horárias de ICU na RMGV apresentam distribuição de frequência próxima da gaussiana, com intervalo de maior ocorrência (~ 50% dos eventos) entre 0 °C e 2 °C; 91,4% dos valores de ICU obtidos para a RMGV estão entre 0 oC e 4 oC, indicando maior ocorrência de eventos de intensidade fraca e moderada, 0,3% do período apresentou ilha de calor de intensidade forte (4-6 °C) e muito forte (6-8 °C). O estudo possibilitou verificar que os eventos de ICU na RMGV são mais intensos durante o dia, nas estações de primavera e verão, e estão associados aos horários de maior carga térmica no ambiente, nas escalas horária e sazonal. Também foram verificados eventos de ilha de calor negativa (cool island) em 8,3% dos casos, condição ocorrida quando a área rural esteve mais aquecida que a área urbana. Os eventos de ilha de calor negativa foram mais frequentes entre 7 e 9 horas, nos meses de janeiro e julho, e estiveram sempre associados à atuação de sistemas atmosféricos com formação de nebulosidade, como frentes frias, ZCOU e ZCAS.
Conceito de sistemas agrovoltaicos no Nordeste: uma solução de desenvolvimento ecossustentável para o Semiárido nordestino
Authors: Lacerda Francinete Francis , Neves Fabrício Monteiro , Canel Lautemyr Xavier Cavalcanti , Lopes Geraldo Majella Bezerra
Published: January 2023

Com esse artigo vislumbram-se as possibilidades de ganhos com a produção de energia fotovoltaica (solar), em consórcio com a produção de alimentos e mudas de reflorestamento (Spondias tuberosa), num sistema denominado “agrovoltaico”. Há ainda o tratamento e reutilização de águas cinzas e negras para produzir água de qualidade para irrigação para atender a produção de mudas e mitigar poluição. Esta iniciativa já qualificou mais de 700 pessoas no manejo dessas tecnologias. Ao descrever essa alternativa produtiva, adaptada às áreas de clima semiárido, busca-se indicar uma alternativa que supere o modelo da produção tradicional de criação de animais e policultura de baixa eficiência. São alternativas econômicas sem um vínculo com sistemas produtivos ancorados em oferta de água abundante e que, ao mesmo tempo, buscam interação com o Sistema Inovativo Regional - SIR, de forma a responder às carências produtivas regionais, em particular as de emprego e renda.
Tem risco, mas na minha casa não: análise da percepção ambiental de risco da comunidade Amazonas, Petrópolis – RJ
Authors: Ferreira Cristiane Oliveira , Richter Monika
Published: January 2023

Petrópolis, localizada na região serrana do Rio de Janeiro, sofreu ao longo da história inúmeros desastres relacionados aosmovimentos de massa. Embora haja um esforço por parte do município, principalmente da defesa civil em alertar a população sobre os riscos associados às áreas de maior ocorrência do fenômeno, bem como ações emergenciais no sentido de minimizar os danos, ainda assim, a problemática é recorrente. Neste sentido, esta pesquisa tem como objetivo analisar a percepção da população residente em áreas de risco na comunidade Amazonas, localizada no município de Petrópolis-RJ. A região apresenta diferentes graus de risco relacionados aos movimentos de massa e tem vivenciado esses desastres nas últimas décadas. Para tanto, analisou-se o histórico do município a fim de compreender o processo de ocupação das encostas, bem como aspectos relacionados à condição socioeconômica da comunidade, observando-se que a vulnerabilidade econômica se apresenta como fator chave para compreensão desta realidade. Realizou-se entrevistas com moradores, utilizando-se a Análise Textual Discursiva, para a compreensão dos resultados alcançados. Conclui-se que os moradores compreendem as causas naturais e antrópicas para a ocorrência dos desastres, estão cientes das possíveis medidas de prevenção, assim como da presença de áreas apontadas como de risco pela Defesa Civil, porém a maioria não se reconhece inserido nestas áreas, negando a sua própria condição. Esta análise pode subsidiar ações de gestão dos riscos, que tem se mostrado um dos maiores desafios na atualidade, indicando a necessidade de maior integração da população neste processo.
Geoparques: desenvolvimento sustentável e agenda 2030
Authors: Fleig Raquel , Nascimento Iramar Baptiptistella do , Valdati Jairo
Published: January 2023

Geoparque é um território reconhecido pela UNESCO pelo seu patrimônio abiótico onde se aplicam estratégias de desenvolvimento sustentável, atenta ser uma estratégia para o alcance da sustentabilidade global e uma maneira sociocultural particular de uma população de compreender o contexto da natureza local. A pesquisa teve como objetivo principal identificar como os geoparques podem cumprir a agenda 2030, e como objetivos específicos conhecer quais geoparques já existem, que propósitos atendem e quais estão em avaliação no Brasil, revisar os termos pertinentes à criação de geoparques e os desafios de sua implantação. O estudo bibliográfico ocorreu por meio de uma revisão integrativa nas bases de dados da CAPES: Web of Science e Scopus, em livros, e em alguns sites oficiais de organizações de geoparques. Existem 177 geoparques chancelados pela UNESCO no mundo, e alguns projetos no aguardo de avaliação. No Brasil, o Geopark Araripe, o Seridó e o Geoparque Caminhos dos Cânions do Sul são chancelados pela UNESCO. As diretrizes para o desenvolvimento sustentável nos geoparques envolvem uma concepção multidisciplinar de ações educativas, geoturísticas e geoconservadoras que impulsionam o desenvolvimento sócio econômico local, uma vez que sobrepõe a necessidade de interpretação sobre os elementos abióticos instituídos nas instruções da biodiversidade.  O conhecimento sobre os geoparques já existentes no mundo e sua distribuição territorial permitiram identificar o movimento que os países têm feito a favor do desenvolvimento sustentável e para atender a Agenda 2030.
Os caminhos da bola: a espacialização dos campos de futebol na cidade do Rio de Janeiro (1900-1919)
Authors: Mattos Lucas Nascimento de
Published: January 2023

O artigo em questão tem como objetivo apresentar e analisar a espacialização dos campos de futebol da cidade do Rio de Janeiro nas duas primeiras décadas do século XX. Em um contexto de crescimento da cidade de modelo capitalista, é possível observar o espraiamento do tecido urbano carioca, que leva consigo novas práticas espaciais e de entretenimento. O futebol é uma dessas novas práticas, e o padrão de localização dos campos de futebol encontrados em nosso levantamento segue os chamados eixos de expansão da cidade. Os resultados da pesquisa apontam para uma cartografia do futebol carioca concentrada nos eixos de expansão da cidade, durante as duas primeiras décadas do século XX. O futebol, seus clubes e organizações se apresentam como produtos e produtores do espaço urbano, simultaneamente seguindo o caminho da urbanização da cidade e atuando ativamente no processo tipicamente carioca de rapto ideológico da categoria subúrbio. A metodologia da pesquisa se baseia na perspectiva de método da Geografia Histórica, desdobrando-se nas seguintes atividades: levantamento de dados em jornais e revistas da hemeroteca da Biblioteca Nacional e levantamento bibliográfico em livros, revistas e periódicos científicos. Os mapas e tabelas construídos ajudam a preencher lacunas importantes na bibliografia sobre o futebol carioca, principalmente no que concerne à localização dos clubes e da prática do futebol na cidade, e poderão ser utilizados para novas pesquisas sobre o tema.
O futebol como mercadoria e poder: concepções geográficas sobre o torcer no Brasil
Authors: Vasconcelos Daniel Bruno , Santos Alberto Luiz dos
Published: January 2023

Este artigo apresenta uma contribuição aos estudos do futebol, mobilizando questões concernentes à geografia urbana e à geopolítica. Considerando a dialética que envolve o futebol-espetáculo tornado mercadoria e utilizado como instrumento de poder, serão analisadas, com maior enfoque, as dinâmicas que têm afetado as práticas torcedoras no Brasil. Inicialmente, identificam-se balizas temporais importantes da mercantilização do torcer, dos primórdios elitizados à popularização, tendo como fio condutor o debate sobre os estádios e a cidade. Na sequência, são elencadas algumas estratégias de poder que envolveram as Copas do Mundo de futebol masculino e o modo como elas se desdobraram no modelo contemporâneo de mercantilização do esporte atrelado à venda da cidade. Por fim, destacamos as insurgências e resistências torcedoras a esse processo, elencando possibilidades de políticas voltadas ao reconhecimento e valorização das referências culturais torcedoras que, no entendimento deste artigo, são conteúdos significativos do acervo do patrimônio cultural brasileiro.
Gilmar Mascarenhas e sua geografia do futebol
Authors: Andrade Julia Santos Cossermelli de , Oliveira Leandro Dias de , Castro Demian Garcia , Ferreira Fernando da Costa
Published: January 2023

Esse artigo apresenta, de maneira introdutória, a obra do professor Gilmar Mascarenhas. Trata-se do primeiro geógrafo brasileiro a trabalhar com a temática do futebol e da geografia dos esportes de maneira mais ampla. Apresentamos inicialmente algumas passagens da sua biografia e de sua carreira acadêmica para, em seguida, apresentar um conjunto de textos que ele deixou como um dos mais ricos legados para os estudos da área. Finalmente indicamos alguns orientandos que seguem seus ensinamentos. Com isso desejamos reconhecer a incontestável contribuição deste pensador que, infelizmente, nos deixou precocemente. Ele foi mais uma vítima da violência contra o ciclista nas ruas da cidade do Rio de Janeiro.
Redonda bola
Authors: Sposito Eliseu Savério
Published: January 2023

Resenha. Redonda bola, música e letra de Eliseu S. Sposito, interpretada por Sidney Guri. No Spotify, disco Nosso Canto Geral.
Disponível em https://open.spotify.com/track/3Oa2Hu9Zdzc7ZMEfaJhXkY?si=98f232a44128417b, acesso 12 out. 2022.
Atlas de riscos geológico e hidrológico do estado do Espírito Santo no período 2011-2020: resultados gerais
Authors: Ribeiro Rafael Silva
Published: January 2023

As conclusões dos mapeamentos de risco do Serviço Geológico do Brasil e dos Planos Municipais de Risco na última década impõem a confecção de um novo atlas no Espírito Santo. O objetivo principal desta pesquisa é apresentar os resultados gerais do Atlas de Riscos Geológico e Hidrológico do Estado do Espírito Santo com os dados dessas publicações. Para isso, foram analisados 1.378 setores de risco alto e muito alto de 78 municípios do Espírito Santo relacionados a 12 processos geológicos e hidrológicos. Os dados foram estatisticamente tratados, o que possibilitou a produção das cartas. As cartastraduzem a análise dos seguintes parâmetros: ano de mapeamento, grau de risco, número de construções e população percentual em risco. Novidades foram criadas nesse processo, como o índice de setorização de risco e as análises percentuais municipal e estadual. O índice de setorização de risco é um índice de fácil determinação e que envolve exclusivamente parâmetros avaliados em campo. Informações referentes ao histórico de decretos municipais, danos e prejuízos e regime pluviométrico foram obtidas e adicionadas no atlas. Os resultados mostram que o índice de setorização de risco do Espírito Santo em 2021 é de 147.888 e que quedas de blocos, inundações e deslizamentos planares estão em pelo menos um setor de mais da metade dos municípios capixabas. A metodologia empregada é inédita e mostra-se relevante na quantificação e gestão do risco a desastres naturais.
Índices de aptidão funcional em jogadores de futebol da Seleção Nacional da Jamaica
Authors: Silva Paulo Roberto Santos , Roxo Carla Dal Maso Nunes , Visconti Ana Maria , Teixeira Alberto Alves de Azevedo , Rosa Albertina Fontana , Firmino Mauro Theodoro , Tavares Emídio Valenti , Simões Renê , Montesso Alfredo , Gama Walter , Nichols Denise , Monteiro José Carlos Simões , Sousa Jorge Mendes de
Published: January 2023

O principal objetivo deste estudo foi mostrar alguns índices de aptidão funcional, em 24 jogadores de futebol da Seleção Nacional da Jamaica, com média de idade de 23,9 ± 3,7 anos, equipe pré-classificada para a Copa do Mundo da França. Todos os atletas foram submetidos a uma bateria de testes que constou de: 1) avaliação da potência, resistência muscular e índice de fadiga no teste de Wingate, realizado numa bicicleta computadorizada da marca (Cybex), modelo (Bike); 2) teste isocinético computadorizado de membros inferiores no equipamento da marca (Cybex), modelo (1200); 3) avaliação da flexibilidade pelo teste de Wells & Dillon; 4) exames laboratoriais e 5) avaliação odontológica, que foi realizada por meio de exames clínicos num consultório da marca Funk, modelo MLXPlus. Os seguintes parâmetros e os resultados encontrados foram: Wingate: potência pico corrigida pelo peso = 11,8 ± 1,8 w.kg-1; potência média = 9,1 ± 1,2 w.kg-1; índice de fadiga = 46,2 ± 15,2 %; flexibilidade = 19,8 ± 4,6 cm; exames laboratoriais: urina tipo I; fezes; hemoglobina = 14,3 ± 1,0 g%; ferro = 104 ± 29 ng/dl; ferritina = 81,8 ± 41,7 ug/dl; transferrina = 502,5 ± 113,5 ug/dl; hematócrito =43,5 ± 2,9%; eritrócitos = 4,95 ± 0,40 milhões/m3; glicose = 91,0 ± 8,5 mg/dl; avaliação odontológica: tártaro em 5 (21%); cáries em 24 (100%); gengivites em 10 (42%); endodontia em 3 (12,5%); pulpites em 1 (4%); diastema em 2 (8%); heterotópicos em 13 (54%); extrações realizadas em 14 (58%); extrações não-realizadas em 4 (17%); obturações em 4 (17%); próteses em 16 (67%) e a profilaxia estava sendo feita em 17 (71%) dos atletas examinados; desempenho isocinético: torque de MMII direito a 60° S-1 na extensão = 290,4 ± 95,6 Nm; na flexão = 216,1 ± 31,4 Nm; torque de MMII esquerdo a 60° S-1 na extensão = 291,6 ± 62,5 Nm; na flexão = 205,8 ± 35,8 Nm. Conclusão: apesar da falta de estrutura tecnológica do futebol jamaicano, os resultados demonstraram que os índices de aptidão funcional dos futebolistas avaliados, neste estudo, foram semelhantes aos de jogadores verificados em nosso Centro de Medicina Integrada.
Pluralidade de sentido no conto "Famigerado" de João Guimarães Rosa
Authors: Brant Cordeiro Gustavo Henrique
Published: January 2023

Este trabalho trata das potencialidades da linguagem literária e tem por objetivo identificar algumas propriedades da língua que se potencializam no interior do texto literário. Para tanto, desenvolve-se uma análise do conto “Famigerado” de João Guimarães Rosa, presente na obra Primeiras Estórias. No conto, narra-se a “estória” de uma discussão acerca do significado de uma palavra, “famigerado”, entre um jagunço e um doutor. Como essa palavra é o elemento central da narrativa, observa-se a situação na qual é possível identificar a multiplicidade de significados assumidos por ela. Ao final, a análise permitiu afirmar, seguindo Hansen (2000) e outros teóricos, que a escrita de Rosa explora uma criação “heteróclita”, potencializando os signos linguísticos e gerando, assim, uma pluralidade de sentidos no texto.
Caranguejo Overdrive e o descompasso nacional
Authors: Branco Gabriela Broinizi Pereira
Published: January 2023

Assim como a prosa e a poesia, a dramaturgia brasileira também se debruçou em questões relacionadas a identidade nacional, porém, uma vez que a história da modernização do teatro brasileiro percorreu caminhos mais disformes do que os outros gêneros, a maneira de investigar o Brasil também se deu por outras vias. Em Caranguejo Overdrive, peça de Pedro Kosovski criada em processo colaborativo com a Aquela Cia. de Teatro, o autor, ao contar a história de um homem-caranguejo que ao voltar traumatizado da Guerra do Paraguai, depois de anos em campo de batalha, não consegue mais reconhecer sua cidade natal completamente modificada pelo progresso, colabora com a identificação de caminhos que tentam elaborar o complexo cenário nacional, fazendo emergir um texto que em sua própria estrutura questiona a formação sócio histórica do Brasil, descortina a precariedade das relações humanas atuais e, assim, revela a formação truncada da nossa identidade, que em decorrência do descompasso entre o discurso (É preciso se modernizar) e a ação concreta (Mudança sem superação), mostram como a história do Brasil se repete initerruptamente a ponto ser incorporada à própria forma do teatro nacional.
Linhas de soco & madrugada em fuga
Authors: Capilé André
Published: January 2023

Texto de criação literária.
The Church Sinister
Authors: Harmes Marcus , Harmes Meredith , Harmes Barbara
Published: January 2023

The exorcism of Michael Taylor in 1974, which led to murder, pushed Anglican exorcisms into the public gaze. This article proposes a particular trajectory of Anglicanism and the preternatural into popular culture and popular awareness of religion. The Taylor case was one of the catalysts for private anxiety among clergy about the preternatural in the Church of England. By the early 1970s, some clergy ignited public debate including open letters and television appearances to declare the Church of England should not exorcise and complete belief in the accounts of the Gospels was not necessary. Their debate moved to television, some clergy declaring on talk shows the Church should not exorcise, others consenting to be filmed exorcising. Clergy exorcising on screen gave visual cues and content to fictional drama that traversed different genres and channels. This article identifies a common element to drama showcasing the Church and the preternatural, showing the institution and its clergy as weak or absent in the face of evil. Drama brought to the fore clerical concerns that engaging publicly with the preternatural made the Church seem theologically confused and denuded of spiritual authority, a point reinforced by the tragic real-world consequences of the Anglican exorcism of Michael Taylor.
Two noteworthy Calea (Asteraceae: Neurolaeneae) from contact areas of the Atlantic Forest and Cerrado of Brazil
Authors: BUENO VINICIUS R. , CASSOL Ana PaulaA. P. V. , LEROY C. J. , BUENO M. L. , HEIDEN GUSTAVO
Published: January 2023

Systematic studies in the Calea myrtifolia complex have revealed two noteworthy new taxa from the contact, relict and transitional areas of the Atlantic Forest and Cerrado domains in Brazil: Calea grandiflora and Calea × parviantha, both having been treated as C. myrtifolia, now considered endemic to Minas Gerais state, Brazil. Thus, we herein provide morphological descriptions, illustrations, geographical distribution maps and discuss their taxonomic affinities. Moreover, their potential distributions are predicted. Calea grandiflora is related to C. arachnoidea and is recognized by the basal acrodromous venation (vs. semicraspedodromous), outer phyllary series 12.2–20 × 4.2–10.6 mm long (vs. 9–12 × 3–5 mm), and ray floret corolla 16.9–31 mm long (vs. 10–12 mm). Calea × parviantha is a new nothospecies, supported by a unique set of character states partially shared with the parental species C. parvifolia and C. triantha. The new hybrid species has intermediate morphology, as demonstrated by a multivariate analysis. It differs from C. parvifolia by the hispid, hispidulous or glabrous stems (vs. puberulous or puberulent) and coriaceous leaves (vs. chartaceous leaves), and from C. triantha by the rounded leaf base, sometimes subcordate (vs. cordate) and pappus scales 1.1–2.7 mm long (vs. 0.8–1.3 mm). Furthermore, we provide a taxonomic key for Calea in the states of São Paulo and Paraná.
Akanthomyces zaquensis (Cordycipitaceae, Hypocreales), a new species isolated from both the stroma and the sclerotium of Ophiocordyceps sinensis in Qinghai, China
Authors: WANG YONG-HUI , WANG WEN-JING , WANG KE , DONG CAI-HONG , HAO JI-RONG , KIRK PAUL M. , YAO YI-JIAN
Published: January 2023

An undescribed taxon of entomopathogenic fungi, Akanthomyces zaquensis, was introduced based on the collections from Duoxiao Village beside the Za Qu River in Qinghai Province, China. The taxon is characterized by its host and habitat of isolations from both the stroma and the sclerotium of Ophiocordyceps sinensis and by producing single and lanceolate or narrowly lageniform phialides directly from the aerial hypha. Phylogenetic analyses based on the combined ITS, SSU, LSU, tef1, rpb1 and rpb2 sequences supported the taxon as a new species of Akanthomyces.
Exobasidium siroboe sp. nov. (Exobasidiaceae) causing Exobasidium fruit deformation on Symplocos myrtacea in Japan
Authors: NAGAO HIDEYUKI , KUROGI SYUICHI , OGAWA SEIJI
Published: January 2023

Fruit deformation of Symplocos myrtacea Siebold et Zuccarini (Japanese sapphireberry) caused by Exobasidium species has been reported in Fukuoka Prefecture, Japan but the species involved has not been determined (Ogawa 1999, 2000). Five species and varieties of Exobasidium were recorded on Symplocos species previously (Sydow et al. 1912, Hirata 1981, Ezuka 1991, Nagao et al. 2003). Exobasidium symploci Ell. &Mart. was identified on S. tinctoria (L.) L’Hér. in Alabama, Florida, Indiana, and North Carolina, USA. Two Exobasidium spp. were recorded from Tropical Asia: E. indicum Syd. & Butl. on S. theaefolia D. Don in Darjeeling and E. javanicum Rac. on S. spicata var. subsessilis Koord. & Valeton (syn. S. cochinchinensis subsp. laurina (Retz.) Noot.) in Java. In Japan, the following Exobasidium spp. were described on Symplocos species: E. symploci-japonicae var. symploci-japonicae Kusano & Tokubuchi and E. symploci-japonicae var. caprogenum Nagao & S. Ogawa on S. lucida (syn. S. kuroki Nagam.), and E. sakataniense S. Hirata on S. theophrastaefolia Siebold & Zucc.
New species and new records of Miroculis Edmunds, 1963 (Ephemeroptera: Leptophlebiidae) from Chacoan Domain in northeastern Brazil
Authors: RODRIGUES JACKSON A. O. , NASCIMENTO STÊNIO R. S. , RAIMUNDI ERIKCSEN A. , LIMA LUCAS R. C.
Published: January 2023

The genus Miroculis Edmunds, 1963 (Ephemeroptera: Leptophlebiidae) is endemic to South American with 27 described species. In Brazil, 21 of these are known to occur. The present paper describes three new species of Miroculis Edmunds, 1963. Miroculis (Miroculis) botafora sp. nov. is described based on a male imago collected in a transition area between the Cerrado and Caatinga biomes in Piauí State, Brazil. Two species are described based on nymphs and adults: Miroculis (Miroculis) azevedoi sp. nov. and Miroculis (Miroculis) quilombola sp. nov.; both were collected in a Cerrado region of Maranhão State, Brazil. Additionally, new distribution records of Miroculis (Miroculis) fittkaui Savage & Peters, 1983 are provided.
A downside to high aspirations: Immigrants’ (non-)success in tertiary education
Authors: Klein Daniel , Neugebauer Martin
Published: January 2023

While many studies document the ambitious educational choices of immigrants across Europe, researchers have only recently begun to investigate the consequences of these ambitious choices. Our article extends this emerging literature by focusing on immigrants’ success throughout tertiary education in Germany. We argue that after the transition into tertiary education, immigrants lose their advantages over native students regarding higher aspirations while retaining or even increasing their disadvantages regarding academic achievements, which ultimately results in a higher risk of dropping out. Analyses based on data from the German National Educational Panel Study (NEPS) confirm our hypotheses. Net of socioeconomic background and prior academic achievements, immigrants enter tertiary education with similar aspirations as their native peers. At the same time, immigrants, especially those of Turkish origins, have lower grades and competency levels. Furthermore, immigrants continue to receive lower grades during tertiary education and have a considerably higher risk of dropping out. We conclude that immigrants’ high aspirations enable them to enroll in tertiary education at comparably low levels of academic achievement but ultimately increase the risk of academic failure. We discuss possible policy measures to improve the situation of immigrants.
Vascular “Long COVID”: A New Vessel Disease?
Authors: Zanini Giada , Selleri Valentina , Roncati Luca , Coppi Francesca , Nasi Milena , Farinetti Alberto , Manenti Antonio , Pinti Marcello , Mattioli Anna Vittoria
Published: January 2023

Vascular sequelae following (SARS-CoV-2 coronavirus disease) (COVID)-19 infection are considered as “Long Covid (LC)” disease, when occurring 12 weeks after the original infection. The paucity of specific data can be obviated by translating pathophysiological elements from the original Severe Acute Respiratory Syndrome-Corona Virus (SARS-CoV-2) infection (In a microcirculatory system, a first “endotheliitis,” is often followed by production of “Neutrophil Extracellular Trap,” and can evolve into a more complex leukocytoklastic-like and hyperimmune vasculitis. In medium/large-sized vessels, this corresponds to endothelial dysfunction, leading to an accelerated progression of pre-existing atherosclerotic plaques through an increased deposition of platelets, circulating inflammatory cells and proteins. Associated dysregulated immune and pro-coagulant conditions can directly cause thrombo-embolic arterial or venous complications. In order to implement appropriate treatment, physicians need to consider vascular pathologies observed after SARS-Cov-2 infections as possible “LC” disease.
Cohesive zone phase field model for electromechanical fracture in multiphase piezoelectric composites
Authors: Tarafder Preetam , Dan Saikat , Ghosh Somnath
Published: January 2023

This paper introduces a coupled electromechanical finite deformation phase field model for crack propagation and interfacial decohesion in multiphase piezoelectric composites with interfaces. The crack phase field model is augmented with cohesive traction-separation laws at the material interfaces, derived from a cohesive potential function. A Gibbs free energy density function is proposed, allowing for the incorporation of the anisotropic elastic stiffness of the piezoelectric material. Numerical simulations exhibiting different failure mechanisms are carried out to demonstrate the efficacy of the model. Effects of external electric field on crack evolution and the competition between penetration and deflection of a crack impinging on an interface are investigated. Limited verification tests are conducted with theoretical results. Finally, the model is used to simulate fracture in nonuniform piezocomposite microstructures. The effect of crack propagation on the evolution of the electric field with different crack face conditions are analyzed. Differences in the electromechanical responses of piezocomposites due to different fiber distributions are also observed.
Challenges and Prescriptions for Homeless Drug Users’ Social Reintegration; An Experience of Partnerships Between Iran and Europe NGOs
Authors: Moghanibashi-Mansourieh Amir , Puyan Daryush , Radfar Ramin , Jafarian Mohammad , Legl Thomas , Mattsson Regina , Hornberg Esbjorn , Atefi Faezeh , Neuretter Iris , de Witte Cressida , Farnam Rabert , Binazade Mohammad , Deilamizade Abbas
Published: January 2023

The research addressed challenges and prescriptions for reintegration of homeless people who use drugs. Data were collected through conducting semi-structured interviews. Twenty-nine participants were recruited. The primary codes were extracted and divided into two main categories of challenges and prescriptions; the former included becoming homeless after a long term recovery, workplace stigma, service users’ different cultural backgrounds, dismissing the 12-Step Program, message fatigue, negative effect of relapse on groups and cyberspace overuse; and the latter included connection by hook or by crook, abstinence-harm reduction orientation, organizational service collection, pushing boundaries of interventions, and expanding services umbrella.
The Past and Future of Gender Research in Marketing: Paradigms, Stances, and Value-Based Commitments
Authors: Peñaloza Lisa , Prothero Andrea , McDonagh Pierre , Pounders Kathrynn
Published: January 2023

This systematic literature review enhances paradigmatic/metaphysic analyses by examining how value-based commitments, intellectual personae, and stances impact the diversity, relevance, and consideration of ethics in gender research published by the top-tier marketing journals in the past 30 years. Theoretical contributions (1) explain how commitments to research values and practices constitute personae and particular stances toward research, (2) attribute value commitments to quantitative/positivist as well as qualitative/neohumanist research, and (3) implicate stances that favor particular theories and procedures and in turn enable the hierarchical development of gender research and its marginalization in the field. Recommendations elaborate the analytic, reflexive, and administrative training and research activities that will foster and reward more relevant, accurate, and ethical research on gender in the marketing academy and in industry. This work is of interest to persons dealing with gender identities, communities, and social issues, those working for greater gender representation and participation in firms and civic organizations, and those concerned with leveraging better marketing research for a better world.
Effects of eCoaching on the Occurrence, Equity, and Variety of Behavior Specific Praise During Mursion™ Simulations
Authors: Horn Annemarie L. , Rock Marcia L. , Chezan Laura C. , Bobzien Jonna L. , Karadimou Olga , Alturki Aeshah
Published: January 2023

Engaging in deliberate practice opportunities during special education teacher preparation may increase the implementation and sustainability of evidence-based practices with fidelity in K-12 classrooms. We used a concurrent multiple baseline design across participants to evaluate the effects of providing immediate feedback through eCoaching with online Bug-In-Ear (BIE) technology on special education teacher candidates’ acquisition and sustained use of behavior specific praise (BSP) during Mursion™ classroom simulations. We also measured equitable praise rates and used the Behavior Specific Praise Observational Tool (BSP-OT) to evaluate teacher candidates’ praise variety. Results showed a functional relation between the intervention and teacher candidates’ use of BSP. Maintenance, equity, and praise variety data indicated promising social validity findings.
The relationship between diet, exercise, and inflammation in college students: A cross-sectional study
Authors: Arikawa Andrea Y. , Kraft Diane , Harris Michel , Perez Doreen , Bednarzyk Michele , Ross Jenifer M.
Published: January 2023

Background: Important changes in lifestyle habits, especially diet, typically occur during the transitional period between high school and college and some of these changes may increase the risk of inflammation. Aim: The purpose of this study was to investigate the relationship between lifestyle factors and inflammation in college students. Methods: Students enrolled in a southeastern university participated in this cross-sectional study. Participants completed online questionnaires for assessment of demographics, supplement and dietary intake, sleep quality, and perceived stress. Body composition was measured during a clinic visit via air displacement plethysmography and blood and urine were collected for measurement of C-reactive protein (CRP) and cortisol, respectively. Analysis of variance was used to examine associations between tertiles of CRP levels and lifestyle variables and a linear regression model was fit to investigate whether there were any significant predictors of CRP levels. Results: Analysis included data for 83 participants for whom serum CRP levels and diet intake were available. Approximately 68% of the participants were female; mean age and body mass index (BMI) were 24 years and 23.4 kg/m2, respectively. Alcohol intake was significantly associated with increasing CRP levels ( P = 0.017). No other dietary variables or lifestyle characteristics such as sleep quality, perceived stress, or BMI were associated with tertiles of CRP. The best model to predict CRP levels included urinary cortisol, aerobic exercise duration, alcohol, and vitamin E intake ( adjusted R2=0.27). Conclusion: Alcohol and vitamin E intake were found to be associated with increased CRP levels.