bluuebunny/crossref_metadata_2025 huggingface dataset:
Managing Waste Disposal System through Household Identification and Billing System (HIBS)
Authors: Odeyemi Abayomi Samuel
Published: August 2022

This paper explores the methodology of managing waste disposal system in Abeokuta metropolis. It investigated if the current waste disposal system can guarantee sustainable healthy environment. The study examined waste disposal practices of 400 household in the Abeokuta Central Business District in line with the existing government approved waste management system using a self-developed questionnaire and a simple frequency distribution and bar charts to analyze data. It found that majority of the households explore their own ways of disposing waste without minding the effect on their health and the environment. The study therefore recommends a better and more effective way of managing waste in the metropolis through household identification and billing system (HIBS).
Relationship between Hotel characteristics and Customer Loyalty Among Star-Rated Hotels in Kenya’s North Rift Region
Authors: Jemaiyo Beatrice
Published: August 2022

The most crucial problem that organizations confront when the level of competition in the market rises is how to cultivate customer loyalty and increase customer lifetime value. However, because of the complexities of the competitive market, it is becoming increasingly challenging to establish and maintain consumer loyalty. Customer loyalty is anticipated to rise because of hotel characteristics. Therefore, it is necessary to assess the degree to which hotel characteristics have a positive and substantial impact on customer loyalty. As a result, this study used a cross-sectional survey of fourteen (14) star-rated hotels in Kenya's North Rift Region to assess the association between hotel characteristics and customer loyalty. A cross-sectional research survey design was utilized to randomly choose 384 visitors among the hotel guests who stayed there between January and June 2019 using the Multi-Stage Sampling Method. The respondents were given a questionnaire, which was used to gather the data. The Cronbach's alpha value, which has a coefficient of 0.7, was used to assess the reliability of the survey items. Expert evaluations were used to assess the validity of the questionnaire's items. Descriptive and inferential statistics were used to present the findings. The hypothesis regarding the association between hotel characteristics and customer loyalty was tested using simple and multiple linear regression analysis. According to the study, there is a substantial correlation between hotel attributes and client loyalty, with β coefficient values of 1.079, respectively, at p < 0.05. The model's overall significance was R = 0.830, R2 = 0.689, and P = 0.005. As a result, the study concludes that there is a strong positive correlation between hotel attributes and client loyalty. The research advises hotel owners to make their establishments accessible, get favourable star ratings, and keep expanding their business to be able to match client expectations in order to attract their patronage.
Impact of Self-Management Theory as an Epistemologically Approach and the Directing Methods: Pedagogy, Andragogy, Cybergogy, and Heutagogy on Meta-Human Resource Management (Meta-HRM)
Authors: Saeed Mohamed Nasr
Published: August 2022

Why do some managers fail to direct their subordinates correctly while some may succeed? Why subordinates may respond to the permanent-orientations and/or daily-directions while others do not? How learning approaches effect on managers’ behavior and self-management theory? Are all these challenges considered meta-management? This research is empirical research which methodically providing an answer to these questions. The answer presenting in a diagnostic and an epistemologically analytical method about Antropogogy (Pedagogy to Andragogy) with Cybergogy directing and Heutagogy-Self-determined). The managers' failure in practicing the function of direction and the failure of subordinates to respond to permanent-orientations and/or daily-directions is due to the lack of awareness of self-management theory, adult personality theory, the deficiency in adopting Cybergogy-social media directing and anthropogogy (Andragogy and Heutagogy) self-directed based learning approaches, and the lack of awareness of what is Meta-HRM.
Entrepreneurial Leadership and Managerial Sustainability
Authors: Udofia Ukeme Victor , Brownson Christabel , Okurebia Samuel
Published: August 2022

Entrepreneurial leadership has been tipped as one of the millennium solutions to challenges associated with the current competitive and dynamic global business environment. Majority of businesses operating in the localities of Akwa Ibom State in Nigeria including Ikot Ekpene and Uyo, the state capital are on small and medium scale. For decades now, Small and Medium Scale Enterprises (SMEs) are considered as an important aspect of Nigeria’s economy and this makes it quite necessary to investigate the extent to which entrepreneurial leadership behaviour may lead to managerial sustainability. Considering this fact, this study seeks to examine the effect of entrepreneurial leadership behaviour on managerial sustainability in Akwa Ibom state, Nigeria. The study employed a quantitative survey research design. This study targeted a population of 135 owners/ managers who assume leadership positions in SMEs across Akwa Ibom state. This number cuts across sectors like food processing, livestock rearing, trading, art/craft, bakery, table water, fashion and designing/hair dressing and ICT. Out of this figure 101 owners/managers were selected to represent the sample through purposive sampling technique. The cleansed data was further quantitatively analyzed by product moment correlation and multiple regressions. Results of correlation analysis reveal that there is significant relationship between all the constructs of Entrepreneurial leadership (miner behavior, explorer behavior, accelerator behavior and integrator behavior) and managerial sustainability. The result of regression analysis showed that miner behavior, explorer behavior, accelerator behavior and integrator behavior jointly contribute to managerial sustainability. This study concludes that entrepreneurial leadership behaviors of managers/owners of SMEs significantly affect managerial sustainability of such SMEs. Arising from the findings and conclusion, it is recommended amongst others that mangers/owners of SMEs should enhance their innovation capacity and expand innovative entrepreneurship.
The Impact of Shadow Education on Academic Performance of Secondary School Students In Nigeria
Authors: Adeniyi Adewale Ojo
Published: August 2022

This paper examines the impact of shadow education on the academic performance of secondary school students in Nigeria. Indeed, thousands of the secondary school students in Nigeria attend shadow education , because they believed that shadow education is the only way to improve their academic performance and to support their mainstream education and similarly, their parents have optimistic on shadow education, because they always eager finding nearness centres or employ tutors for their children within their apartments. Therefore, we have two types of shadow education formal and informal. Informal which takes place at home, while formal takes place within the school premises. Thus, students are lured to attend shadow education upon the level of socio- economic background of their parents neither upper class, middle class or lower class even a situation hardship economy of the country is not really barriers for them to attend shadow education because they believed that there is more advantageous in which they can benefits from shadow education rather than mainstream education.Yet, shadow education creates room for proper interaction between the teachers and students and make it easily for the students to express their views freely without fear or panic. Similarly, it also allow the tutors to have additional incomes apart from main salary from the mainstream education, However, shadow education has different names in Nigeria such as prep, lesson, continuous education and coaching . Therefore, many parents like to send their children to standard formal education while informal education the tutors employ to teach their children at their apartments.
Post-Compulsory Students Learning Styles and Resilience in London (U.K.)
Authors: Rasheed-Karim Walifa
Published: August 2022

Research on learning style models advocate that students are more likely to achieve learning goals by matching teaching styles with learning styles. This paper investigates students’ learning styles by the Learning Styles Questionnaire (LSQ) as it conveys the opportunity to build resiliency among students. The nature of resiliency has also been explored using multiple measurements. The paper’s investigation includes a short scale of measuring resiliency used by post-compulsory researchers. Students learning styles were examined in terms of ethnicity and gender and their relationship with course types and resilience. A research study in London asked thirty students (15 males and 15 females) to complete the LSQ and measurement of resilience items. The results showed that students’ learning style was not related to ethnicity, gender, qualification type, or resilience. These findings support some research. The research implies that triangulation of measurements is necessary with a larger number of participants across types of courses and locations. Furthermore, students’ resilience needs to be defined in terms of wellbeing, gender, and ethnicity across the U.K.
Sınıflar Arası Kenar Payını Genişletmek İçin Yeni Bir Örnek Seçim Algoritması
Authors: AYDIN Fatih
Published: August 2022

As discarding superfluous instances in data sets shortens the learning process, it also increases learning performance because of eliminating noisy data. Instance selection methods are commonly utilized to undertake the abovementioned tasks. In this paper, we propose a new supervised instance selection algorithm called Border Instances Reduction using Classes Handily (BIRCH). BIRCH considers k-nearest neighbors of each instance and selects instances that have neighbors from the only same class, namely, but not having neighbors from the different classes. It has been compared with one traditional and four state-of-the-art instance selection algorithms by using fifteen data sets from various domains. The empirical results show BIRCH well delivers the trade-off between accuracy rate and reduction rate by tuning the number of neighbors. Furthermore, the proposed method guarantees to yield a high classification accuracy. The source code of the proposed algorithm can be found in https://github.com/fatihaydin1/BIRCH.
Access to Anthropological Evidence and Documents Created in Native Title Litigation
Authors: Moss Aaron
Published: August 2022

Documents are critical in native title litigation. This article explores the different methods of, and common problems encountered when, accessing such documents. By examining recent decisions dealing with the ‘Hearne v Street obligation’, non-party access requests, and legal professional privilege, this paper explores how the Court has grappled with the translation of general principles of practice to the unique context of native title litigation. It observes the Court has refused to create special native title rules, but rather has pragmatically applied general principles to native title matters on a case-by-case basis. Accordingly, close attention to these judicial developments is necessary, lest the interests of one’s clients, or of First Nations persons, be adversely affected by inappropriate document disclosure.
Molecular identification of Enterococcus spp associated with subclinical mastitis in dairy animals in Algeria and their antimicrobial resistance profile
Authors: Beldjilali Asmaa , MERZOUK Yamina , HAOUHACH Sadika , DIB Wafaa , BOUDJEMAA Abdallah , ZABOURI Younes
Published: August 2022

Enterococcus genus is one of the opportunistic pathogens and responsible for mastitis in dairy animals. This study aimed to investigate the occurrence of enterococci associated with subclinical mastitis in goat, cow and camels in Algeria and to assess their antimicrobial resistance profiles. A total of 374 milk samples from udder quarters were tested for a subclinical mastitis (SCM) using the CMT. The positive samples were subjected to microbiological analysis for identification of Enterococcus spp by biochemical and molecular techniques using 16S rDNA sequencing and phylogenetic analyses. Eight strains of enterococci were tested to their antibiotic sensitivity profiles. The data revealed that 34, 31% of samples showed presence of SCM, meanwhile Enterococcus spp were occurred in 38.9% of positive milk. According to phenotypic criteria, 50 isolates were identified as Enterococcus faecium 70% (35/50) followed by Enterococcus faecalis 18% (9/50) and 12 % (6/50) were nonenterococci. Only eight isolates were confirmed to be Enterococcus spp using 16S rDNA sequencing technique. The antibiotic susceptibility showed that 85.5 % and 62.5% of Enterococcus feacium were resistant to Oxacillin and Penicillin respectively, while most of isolates were susceptible to Ciprofloxacin. In this study, Vancomycin-resistant enterococci (VRE) were found in 37.5% of isolates. Nevertheless, 62.5% of the tested strains displayed multi-drug resistances (MDR) across different patterns. This study highlights virulence and harmfulness of Enterococcus strains isolated from subclinical mastitic milk, which suggest continuous inspection and monitoring of dairy animals in Algeria.
Antifungal activity of lactic acid bacteria isolated from raw camel milk againts Alternaria alternata and identification of antifungal substance
Authors: MERZOUK Yamina , Zabouri Younes  , Beldjilali Asmaa Fatima  , El Hachemi Mohamed Fayçal  , Mohamed-Benkada Mustapha  , Berrabbah Alioua Amel
Published: August 2022

The phytopathogenic filamentous fungi are responsible for the deterioration of various food products, such as fruits or vegetables, causing significant economic losses. They are also capable of producing several mycotoxins in infected plants and fruits.Lactic acid bacteria (LAB) are considered to be natural antagonists of these dangerous microorganisms. In the present study, 16 strains of LAB isolated from raw camel milk from various regions of Algeria, were the subject of phenotypic and genotypic identification, and they were tested for their antifungal activity. The well method was performed on five strains of lactic acid bacteria against four strains of the toxigenic and spoilage phytopathogenic fungus, Alternaria alternata, isolated from the stems, leaves, roots and fruits of tomatoes and carrots. A study of nature metabolites showed that these metabolites are stable at temperature, and keep the nature of the metabolites with the treatment with proteolytic enzymes such as Pepsin, Lysozyme and Trypsin, so their activity increases with increasing the pH of the culture medium. No loss of antifungal activity of the five selected strains was observed after treatment of the metabolites by heating at 4°C, 30°C, 45°C and 90°C. Internal transcribed spacer polymerase chain reaction (ITS-PCR) analysis and 16S rDNA sequencing were used to characterize and identify LAB isolates that showed varying levels of inhibition of fungal growth. Two strains of LAB, identified as Enterococcus lactis and E. faecium, had the strongest antifungal activity, suggesting potential application in food technology as bio-preservatives against phytopathogenic and food-altering fungi.
Intermittent Fasting Improves Memory, Reduces Anxiety and Enhances Neurotransmitter Levels In Zebrafish (Danio Rerio)
Authors: Tamilarasan Shanmugasundaram , Devaraj Uthirakumar , Ramu Ammu , Virumandi Sethupathi , Bichandarkoil Jayaram Pratima , Elumalai Balamurugan
Published: August 2022

The zebrafish is an excellent model for social, behavioural and neuroscience studies. The brain controls food intake, energy expenditure, insulin secretion, hepatic glucose production, and glucose fatty acid metabolism in adipose tissue and skeletal muscle. Caloric restriction is thought to be the main reason for disease regulation. The sensory system strengthens by altering the union of neurotrophins and synapses. The experimental groups studied in this research included control, uncontrolled diet-(overfed), 12hrs, 24hrs, 48hrs intermittent fasting, respectively. The study groups were subjected to a T-maze test to examine zebrafish memory and learning changes. The novel tank test (NTT) and light and dark (LDT) tests investigated stress-like behaviour. The levels of dopamine, serotonin, epinephrine, and nor-epinephrine were measured using a spectrofluorimetric method. We found behaviour and enhanced neurotransmitter levels in the groups that were subjected to intermittent fasting than the overfed and control groups which may be due to the hippocampus derived neurotrophic factor that in areas memory power and reduce anxiety from this experiment it is evident that intermittent fasting could bring a positive outcome in memory maintenance by lowering the anxiety and thereby keeping a check in neurotransmitter levels.
Sequencing of RB1 Gene and In Silico Analysis in Western Algerian Population Affected by Retinablastoma
Authors: Louhibi Lotfi , Tabet Aoul Nacera , Boubekeur Amina Mama , Mahmoudi Khadidja , Saidi-Mehtar Nadhira
Published: August 2022

Retinoblastoma (RB) is an intraocular malignant tumour which occurs in children during the first months of life, with an incidence of 1 in 15,000 live births. Antioncogene RB1 located on chromosome 13q14.2, is at the origin of this pathology. For retinoblastoma development, two allele mutations of this gene are required. The aim of this study firstly, was to identify mutations that affect the RB1 gene in constitutional level, to detect early subject at risk or asymptomatic carriers and secondly to contribute on the understanding of the molecular pathogenesis. The study concerned 61 patients with retinoblastoma in Western Algeria. DNA from blood was used for amplification and gene sequencing. The results were completed by in-silico analysis using bio-informatic methods to know the mutation impact on the pRB1 protein function. Amplification and sequencing results gave nineteen different variations bases, including eight exonic changes: three missense mutations and five nonsense mutations located in exons 1,7,8,12,18,19,20 and 23. There are an important number of mutations located in twelve RB1 gene introns. These mutations were identified in germinal level for children with no family history of the disease. In conclusion, this study reported two new RB1 mutations in exons 1 and 7 among the eight identified. The mutations described in sporadic forms of retinoblastoma are transmissible forms in 13.11% of cases in our studied population. This study would improve role of genetic testing for management and family screening.
Incidence and epidemiology of wood disease in Algerian citrus orchards
Authors: Benzohra Mohamed , Ammad Faiza , Benchabane Messaoud
Published: August 2022

The wood diseases are very damaging to the culture of citrus and many hosts around the world. It is considered as a complex pathosystem that requires the analysis of its various aspects. In this context, we conducted epidemiological and etiological studies. Our studies were conducted for four consecutive years (2017-2020) on 25 orchards from five localities in Algeria. The results of symptom diagnosis showed the presence of different categories of symptoms; these are the total and/or partial dieback. The examination of the cross-sections of infected wood showed the presence of different forms of inner necrosis. The isolations from the necrotic tissues of the infected trees put often in evidence the presence of a diversified fungal flora dominated by Botryosphaeriaceae fungi. We also recorded an overall infection rate of 23.28% representing a severity index of 1.77 on a scale of four degrees, giving an incidence of 10.76%. The overall assessment of the dieback situation in the studied orchards showed a rapid increase in all epidemiological indices. The statistical analyzes showed that the factors region, age, rootstock, type of irrigation and soil texture had a highly significant effect on the variation of epidemiological parameters. However, the factor year is only moderately significant. On the other hand, the factor cultivar, has no significant effect on these indices. The epidemiological behavior of dieback in these orchards confirms that the spread of the disease is favored by cultural techniques such as irrigation and pruning.
Predicting the Geoeffectiveness of CMEs Using Machine Learning
Authors: Pricopi Andreea-Clara , Paraschiv Alin Razvan , Besliu-Ionescu Diana , Marginean Anca-Nicoleta
Published: August 2022

Coronal mass ejections (CMEs) are the most geoeffective space weather phenomena, being associated with large geomagnetic storms, and having the potential to cause disturbances to telecommunications, satellite network disruptions, and power grid damage and failures. Thus, considering these storms’ potential effects on human activities, accurate forecasts of the geoeffectiveness of CMEs are paramount. This work focuses on experimenting with different machine-learning methods trained on white-light coronagraph data sets of close-to-Sun CMEs, to estimate whether such a newly erupting ejection has the potential to induce geomagnetic activity. We developed binary classification models using logistic regression, k-nearest neighbors, support vector machines, feed-forward artificial neural networks, and ensemble models. At this time, we limited our forecast to exclusively use solar onset parameters, to ensure extended warning times. We discuss the main challenges of this task, namely, the extreme imbalance between the number of geoeffective and ineffective events in our data set, along with their numerous similarities and the limited number of available variables. We show that even in such conditions adequate hit rates can be achieved with these models.
X-Ray Performance of Critical-angle Transmission Grating Prototypes for the Arcus Mission
Authors: Heilmann Ralf K. , Bruccoleri Alexander R. , Burwitz Vadim , DeRoo Casey , Garner Alan , Günther Hans Moritz , Gullikson Eric M. , Hartner Gisela , Hertz Edward , Langmeier Andreas , Müller Thomas , Rukdee Surangkhana , Schmidt Thomas , Smith Randall K. , Schattenburg Mark L.
Published: August 2022

Arcus is a proposed Explorer Class soft X-ray grating spectrometer. It aims to explore cosmic feedback by mapping hot gases within and between galaxies and galaxy clusters and characterizing jets and winds from supermassive black holes and to investigate the dynamics of protoplanetary disks and stellar accretion. Arcus features 12 m focal-length grazing-incidence silicon pore optics (SPO) developed for the Athena mission. Critical-angle transmission (CAT) gratings efficiently disperse high diffraction orders onto CCDs. We report new and improved X-ray performance results for Arcus-like CAT gratings, including a record resolving power for two coaligned CAT gratings. Multiple Arcus prototype grating facets were illuminated by an SPO at the PANTER facility. The facets consist of 32 × 32.5 mm2 patterned silicon membranes, bonded to metal frames. The bonding angle is adjusted according to the measured average tilt angle of the grating bars in the membrane. Two simultaneously illuminated facets show a minor broadening of the Al-K
α
doublet in the 18th and 21st orders with the best-fit record effective resolving power of

R

G

≈

1.3

−
0.5

+
∞

×

10

4

(3σ), about three to four times the Arcus requirement. We measured the diffraction efficiency of quasi-fully illuminated gratings at O-K wavelengths in orders 4–7 in an Arcus-like configuration and compare results with synchrotron spot measurements. After corrections for geometrical effects and bremsstrahlung continuum, we find agreement between full and spot illumination at the two different facilities, as well as with the models used for Arcus effective area predictions. We find that these flight-like gratings meet the diffraction efficiency and greatly exceed the resolving power Arcus requires.
Line-of-sight Elongation and Hydrostatic Mass Bias of the Frontier Fields Galaxy Cluster Abell 370
Authors: Umetsu Keiichi , Ueda Shutaro , Hsieh Bau-Ching , Nonino Mario , Chiu I-Non , Oguri Masamune , Molnar Sandor M. , Koekemoer Anton M. , Tam Sut-Ieng
Published: August 2022

We present a detailed weak-lensing and X-ray study of the Frontier Fields galaxy cluster Abell 370, one of the most massive known lenses on the sky, using wide-field BR
C
z′ Subaru/Suprime-Cam and Chandra X-ray observations. By combining two-dimensional (2D) shear and azimuthally averaged magnification constraints derived from Subaru data, we perform a lensing mass reconstruction in a free-form manner, which allows us to determine both the radial structure and 2D morphology of the cluster mass distribution. In a triaxial framework assuming a Navarro–Frenk–White density profile, we constrain the intrinsic structure and geometry of the cluster halo by forward modeling the reconstructed mass map. We obtain a halo mass M
200 = (1.54 ± 0.29) ×1015
h
−1
M
⊙, a halo concentration c
200 = 5.27 ± 1.28, and a minor–major axis ratio q

a
= 0.62 ± 0.23 with uninformative priors. Using a prior on the line-of-sight alignment of the halo major axis derived from binary merger simulations constrained by multi-probe observations, we find that the data favor a more prolate geometry with lower mass and lower concentration. From triaxial lens modeling with the line-of-sight prior, we find a spherically enclosed gas mass fraction of f
gas = (8.4 ± 1.0)% at 0.7 h
−1 Mpc ∼ 0.7r
500. When compared to the hydrostatic mass estimate (M
HE) from Chandra observations, our triaxial weak-lensing analysis yields spherically enclosed mass ratios of 1 − b ≡ M
HE/M
WL = 0.56 ± 0.09 and 0.51 ± 0.09 at 0.7 h
−1 Mpc with and without using the line-of-sight prior, respectively. Since the cluster is in a highly disturbed dynamical state, this represents the likely maximum level of hydrostatic bias in galaxy clusters.
Synthesizing Stellar Populations in South Pole Telescope Galaxy Clusters. I. Ages of Quiescent Member Galaxies at 0.3 < z < 1.4
Authors: Khullar Gourav , Bayliss Matthew B. , Gladders Michael D. , Kim Keunho J. , Calzadilla Michael S. , Strazzullo Veronica , Bleem Lindsey E. , Mahler Guillaume , McDonald Michael , Floyd Benjamin , Reichardt Christian L. , Ruppin Florian , Saro Alexandro , Sharon Keren , Somboonpanyakul Taweewat , Stalder Brian , Stark Antony A.
Published: August 2022

Using stellar population synthesis models to infer star formation histories (SFHs), we analyze photometry and spectroscopy of a large sample of quiescent galaxies that are members of Sunyaev–Zel’dovich (SZ)-selected galaxy clusters across a wide range of redshifts. We calculate stellar masses and mass-weighted ages for 837 quiescent cluster members at 0.3 < z < 1.4 using rest-frame optical spectra and the Python-based Prospector framework, from 61 clusters in the SPT-GMOS Spectroscopic Survey (0.3 < z < 0.9) and three clusters in the SPT Hi-z cluster sample (1.25 < z < 1.4). We analyze spectra of subpopulations divided into bins of redshift, stellar mass, cluster mass, and velocity-radius phase-space location, as well as by creating composite spectra of quiescent member galaxies. We find that quiescent galaxies in our data set sample a diversity of SFHs, with a median formation redshift (corresponding to the lookback time from the redshift of observation to when a galaxy forms 50% of its mass, t
50) of z = 2.8 ± 0.5, which is similar to or marginally higher than that of massive quiescent field and cluster galaxy studies. We also report median age–stellar mass relations for the full sample (age of the universe at t
50 (Gyr) = 2.52 (±0.04)–1.66 (±0.12) log10(M/1011
M
⊙)) and recover downsizing trends across stellar mass; we find that massive galaxies in our cluster sample form on aggregate ∼0.75 Gyr earlier than lower-mass galaxies. We also find marginally steeper age–mass relations at high redshifts, and report a bigger difference in formation redshifts across stellar mass for fixed environment, relative to formation redshifts across environment for fixed stellar mass.
A Comparison of Solar X-Ray Flare Timescales and Peak Temperatures with Associated Coronal Mass Ejections
Authors: Kahler S. W. , Ling A. G.
Published: August 2022

Recent work has shown that plots of solar flare X-ray peak temperatures, Tm, versus log peak fluxes, Fp, show statistically significant separations of lower Tm flares with fast (Vcme ≥ 1000 km s−1) and wide (Wcme = 360°) strong coronal mass ejections (CMEs) from higher Tm flares with no CMEs or slow (Vcme < 1000 km s−1) or narrow (<360°) weak CMEs. We extend that statistical separation to CME kinetic energies, Ecme. Flares with long-duration timescales also have well-known associations with fast CMEs and solar energetic (E > 10 MeV) particle events. Using a data set of 585 ≥ M3.0 GOES X-ray flares, we ask whether longer flare timescales (rise times, TR; durations from onset to half-power decay, TD; decay times to half power, Td; and decay times to C2, TC2) also statistically discriminate among the three groups of CMEs for speeds, widths, and energies. All log–log plots of flare timescales versus Fp produce significant separations of the three groups of CMEs generally better than those of Tm versus log Fp. We use separations of CME distribution medians to sort the four flare timescales as effective discriminants among the three CME groups. Separations between the confined flares (no-CMEs) and weak CMEs are generally smaller than those between the weak CMEs and strong CMEs. A combination of Tm and TC2 provides optimum group separations, but Tm and log TD or log Td appears best for CME forecasting purposes.
Lisinopril Can Reduce Genotoxicity of L-Asparaginase in Bone Marrow Stem Cells
Authors: Maleek Muthana Ibrahim
Published: August 2022

BACKGROUND: Lisinopril is a medication used to lower blood pressure by inhibiting the angiotensin-converting enzyme (ACE). L-asparaginase is a chemotherapeutic agent used to treat acute lymphoblastic leukemia.
 
 AIM: To Study the effect of lisinopril on the genotoxicity of L-asparaginase (ASNase) in bone marrow stem cells.
 
METHODS: Albino Swiss male mice were divided into three groups. The first group was treated with lisinopril 10 mg/kg/day for 14 days. The second group mice were injected with L-asparaginase 3000 IU/kg. The last group was treated with of lisinopril for 14 days followed with an intraperitoneal injection of L-asparaginase (ASNase) at the end of the 13th day. Genotoxicity was assessed by calculating the percentage of micronucleus (MN) and mitotic index (MI).
 
RESULTS:   ASNase significantly increased genotoxicity by raising the %MN and lowering % MI. When Lisinopril 10 mg/kg/day was administered no significant effect was seen. However, a significant decrease in genotoxic effects was observed when mice receiving Lisinopril were injected with 3000 IU/kg ASNase as compared the group treated with ASNase alone. This effect was manifested by decreasing %MN and increasing %MI. 
 
 CONCLUSION:  Using lisinopril for blood hypertension treatments concurrently with the cancer therapeutic agent, L- asparaginase, decreased its genotoxicity in bone marrow stem cells.
Catalog of the genus Cylindrepomus Blanchard (Coleoptera, Cerambycidae, Dorcaschematini) in the Philippines, with description of a new species from northern Mindanao
Authors: Medina Milton Norman D. , Baul Melbert James G. , Cabras Analyn A.
Published: August 2022

A catalog of the genus Cylindrepomus Blanchard, 1853 in the Philippines, along with the description of a new species from northern Mindanao, is presented. Notes on the ecology, threats, and conservation of the new species are also provided.
Effect of titanium addition on sub-structural characteristics of low carbon copper bearing steel in hot rolling
Authors: Makhatha ME
Published: August 2022

The low carbon copper-bearing steel exhibits high toughness and better weldability. In the present investigation, 0.05C–1.52Cu–1.45Mn stainless steel and its titanium added counterpart which is 0.05C–0.05Ti–1.52Cu–1.45Mn stainless steel were subjected to hot rolling. The hot rolling test followed by quenching to retain the microstructure was done using a hot-rolling mill. The rolling was done at two different temperatures of 800 ℃ and 850 ℃. The characterization of microstructure was done using electron back scattered diffraction and transmission electron microscopy analysis. The 0.05C–1.52Cu–1.45Mn stainless steel when subjected to hot rolling at a lower temperature envisaged a deformed microstructure rather transformed one. However, the same steel at a higher temperature envisages a transformed microstructure. There was no variation in hardness was observed. However, the addition of 0.05 wt% of titanium in 0.05C–1.52Cu–1.45Mn stainless steel influenced the softening and the microstructure showed some recrystallization; the hardness was decreased with the increasing rolling temperature because the solubility of titanium in the austenite phase increased with temperature which leads to suppression austenitic grain/sub-grain growth and hardness. The mean sub-grain size for 0.05C–1.52Cu–1.45Mn stainless steel was 2.75 µm. However, the addition of titanium leads to a decrease in the mean sub-grain size. A marginally larger mean sub-grain size was observed when 0.05C–0.05Ti–1.52Cu–1.45Mn stainless steel was rolled at a higher temperature. A comparatively finer precipitate of copper, titanium and oxy-silicates of Ferrous/Manganese in order of nanometer was formed during rolling at a higher temperature.
Effekte der App Phontasia auf die Lese- und Rechtschreibleistungen von Zweitklässlern
Authors: Pflaumer Nadine
Published: August 2022

Lese- und Rechtschreibleistungen von Grundschulkindern sind sehr unterschiedlich und Lehrer müssen ein differenziertes Angebot an individuellen Lernmethoden bereithalten. Ein Einsatz von methodisch fundierten und empirisch überprüften Apps kann hier Unterstützung bieten. Phontasia ist eine App für das iPad zur Festigung der Graphem-Phonem-Korrespondenzen bis hin zum lexikalischen Lesen und orthographischen Schreiben. Auf der Datengrundlage von N=50 Kindern (Alter M=8,3 Jahre; 28 Jungen, 22 Mädchen) wurde über ein Prä-Post-Follow-up-Design die kurzfristige und langfristige Wirksamkeit der App Phontasia untersucht. Die Kinder der Phontasiagruppe trainierten 6 Wochen lang einmal pro Woche 35-40 Minuten mit der App im schulischen Setting. Die Kontrollgruppe nahm am regulären Deutschunterricht teil. Beide Gruppen hatten dasselbe Lehrwerk, aber unterschiedliche Lehrpersonen. Ein Schwerpunkt der Untersuchung lag auf dem Einfluss der Intervention auf die unterschiedlichen Entwicklungsstufen der direkten und der indirekten Verarbeitungsstrategien. Zudem war von Interesse, ob sich durch die Intervention die Benennungsgeschwindigkeit für Farben, Buchstaben und Zahlen erhöht und in welchem korrelativen Zusammenhang die Benennungsgeschwindigkeit mit der Lese- und Rechtschreibleistungen steht. Die Intervention zeigt eine bedeutsame, signifikante, unmittelbare und nachhaltige Wirkung der App Phontasia im Vergleich zur Kontrollgruppe auf die orthographischen Rechtschreibleistungen. Kurzfristige Effekte traten im Lesen und in der schnellen Benennung von Zahlen auf. Diese Effekte konnten in der Follow-up Studie nicht bestätigt werden. Erwartungsgemäß bestätigten Korrelationen die Zusammenhänge zwischen Benennungsgeschwindigkeit und Lesegeschwindigkeit. Die Ergebnisse lassen darauf schließen, dass die App Phontasia ein sinnvolles und ökonomisches Werkzeug zur Förderung orthographischer Fähigkeiten angepasst an individuelle Lernstile im Klassensetting ist.
Faciliter l'accès à l'apprentissage du français pour tous au sein de parcours adaptables de jeux éducatifs numériques
Authors: Rodi Mireille , Chapuis Nathalie Dherbey , Geoffre Thierry , Alvarez Lionel
Published: August 2022

Le présent article vise à présenter les fondements théoriques et leur transposition pragmatique et didactique qui ont permis le développement d'une plateforme numérique, GamesHub, orientée vers une conception universelle de l'apprentissage et proposant pour ce faire des fonctionnalités numériques additionnelles. Sont explicitées les bases théoriques qui visent à appréhender comment certaines difficultés à effectuer une tâche de lecture-compréhension (en français) peuvent être prises en charge par ces fonctionnalités numériques additionnelles. Ceci peut se réaliser grâce à la réduction des barrières, la diversification des ressources et la personnalisation de parcours d'enseignement/apprentissage articulés, progressifs et adaptables permettant de reproduire les phases d'une séquence didactique. Les obstacles langagiers étant au premier plan lors d'activités de lecture-compréhension, nous nous sommes centrés sur les difficultés spécifiques des élèves allophones et des élèves présentant des troubles développementaux du langage écrit (dyslexies et/ou dysorthographies). Les fonctionnalités additionnelles intégrées aux jeux de la plateforme GamesHub portent ainsi l'objectif de répondre aux besoins de chaque élève, et ainsi favoriser l'accès à l'apprentissage pour tous. Au regard des éléments théoriques développés, nous présentons chaque fonctionnalité additionnelle intégrée à GamesHub et explicitons en quoi elle peut apporter une réponse à des besoins d'apprentissage hétérogènes. Ces développements sont inscrits dans le projet européen interdisciplinaire PEAPL (Plateforme européenne pour l'apprentissage personnalisé des langues) qui vise un enseignement de la lecture-compréhension du primaire à l'université, pour tous les apprenant·e·s, dans une conception universelle de l'apprentissage.
Telehealth as an Innovative Supply Chain and Logistics Management Approach
Authors: Burrell Darrell Norman
Published: August 2022

Job growth for dermatologists is healthy, with a 7 percent demand increase year over year for physicians in general, and a much higher demand increase for dermatologists. Since 2004, vacancies for dermatologists have gone up 80.51 percent, greatly outpacing the national average vacancy growth for most fields. As COVID-19 continues to evolve in the United States (U.S.), now more than ever, medical care is leveraging technology and innovation in its delivery of treatment to patients in need of healthcare. This paper explores telemedicine a logistics and supply chain management option to address the shortage of dermatologists
Missio politica in missio Dei: Integrating politics into God’s eternal mission
Authors: Thinane Jonas S.
Published: August 2022

The understanding of the missio Dei from the point of view of the International Missionary Conference in Willingen has rightly broadened the missiological horizon and promoted new approaches to God’s mission in the world. This conference abandoned the ecclesiological approach to mission and focused attention on God as the foundation or source of mission. Inherently, this new perspective opened the door for other human institutions, such as politics, to be seen as critical participants together with the churches in the missio Dei. Apart from the writings of Saayman and Reimer, not much scholarly work is carried out to further develop the framework of the missio politica as an important tool to enable an analysis of politics in accordance with total salvation as the ultimate goal of the missio Dei. Relying upon literary analysis, this contribution orients itself on such exclusive important works as a basis on which missio politica is strengthened as a missiological framework that examines politics in relation to the ultimate goal of the missio Dei.Intradisciplinary and/or interdisciplinary implications: This article presents research on the development of the missio politica framework in the field of missiology and highlights it as an important framework encompassing the scope of politics in relation to the eternal mandate of the missio Dei.
Identification of immune-related genes in atopic dermatitis, contact dermatitis, and psoriasis
Authors: Zhang Lian , Wang Hai-Liang , Tian Xue-Qiu , Liu Wei-Lan , Hao Yue , Gao Lei
Published: August 2022

Background:

The exact mechanisms and targeted therapies for atopic dermatitis (AD), contact dermatitis (CD), and psoriasis (PS) remain unknown.

Objectives:

This study aimed to identify the biomarkers related to immune and novel therapeutic drugs for AD, CD, and PS.

Methods:

The GSE153007 dataset including 12 AD, 9 CD, and 14 PS samples and 40 control samples, which was obtained from the Gene Expression Omnibus database and analyzed. The immune infiltration level of each sample was then evaluated using the single-sample gene set enrichment analysis (ssGSEA). Then, we screened for immune-related differentially expressed genes (DEGs) that overlapped. The Database for Annotation, Visualization, and Integrated Discovery database was used to perform the gene ontology (GO) biological process. Furthermore, using search tool for the retrieval of interaction gene (STRING), the protein-protein interaction (PPI) was predicted on immune-related DEGs. We also searched the DGIdb database for novel therapeutic drugs for AD, CD, and PS.

Results:

According to ssGSEA results, most immune cells were highly infiltrated in the disease group. GO analysis indicated that AD, CD, and PS were enriched in signal transduction, inflammatory response, immune response, and innate immune response. We further found hub genes related to AD (CD4, ITGAM), CD (CD8A, CD86), and PS (CD4,
CD8A) from PPI network. Moreover, the drug prediction indicated that drugs targeting CSF1R was the most effective for AD, whereas drugs targeting FCGR3A and CD86 were more effective for CD and PS.

Conclusion:

These immune-associated genes such as FCGR3A, CD86, and CSF1R might be regarded as therapeutic targets for patients with AD, CD, and PS.
Use of colchicine in COVID-19 hospitalized patients
Authors: Korra Emad E.A. , AbdelFattah Eman B. , Ahmed Mervat A.
Published: August 2022

Background

COVID-19 has become a global public health challenge. Owing to a lack of knowledge about the virus, a significant number of potential targets for using a particular drug have been proposed. Colchicine is an old drug that has been widely used in autoimmune and inflammatory disorders.

Aim

The aim was to compare the effect of colchicine added to the standard of care treatment versus the standard of care treatment alone in hospitalized COVID-19 cases.

Patients and methods

This retrospective study was conducted on 100 patients who were admitted to Ain Shams University Field Hospital. Patients were divided to two equal groups: group A received colchicine plus the standard of care treatment, and group B received the standard of care treatment.

Results

Group A showed significant reduction in the duration of the constitutional symptoms and hospital stay. Group A showed significant reduction in ICU admission and the need for invasive mechanical ventilation. Furthermore, the mortality rate was significantly lower in group A.

Conclusion

Colchicine is a well-tolerated add-on treatment that significantly improved the constitutional symptoms, reduced the days of hospital stay, reduced the rate of ICU admission, reduced the need for mechanical ventilation, and also significantly improved the mortality rate.
Surgical management of complicated retinal detachment in a case of retinal hemangioblastoma
Authors: Bhende Pramod , Kashyap Himanshu , Nadig Ramya R
Published: August 2022

Background:

A 40-year-old male presented with a complaint of sudden onset diminution of vision in the left eye for 2 weeks. He was a follow-up case with retinal hemangioblastoma in both eyes. He underwent two sittings of fundus fluorescein angiography-guided trans-pupillary thermotherapy 2 years back. Since then, he was regularly followed up for 2 years with stable vision and stable retinal findings. At present, the best-corrected visual acuity (BCVA) in the right eye is 6/6, and in the left eye, it is counting fingers 2 meters. On fundus examination, he had one active hemangioblastoma in the right eye and total retinal detachment in the left eye with multiple active lesions. The right eye was treated with a single sitting of thermotherapy, and the left eye underwent pars plana vitrectomy and angioma excision, followed by silicone oil tamponade. The immediate and late post-operative periods were uneventful, with successful anatomical and functional outcomes. The left eye BCVA on late follow-up was 6/36, no further treatment was advised, and the patient was kept under follow-up and observed closely.

Purpose:

To educate regarding the systemic workup, diagnosis, and surgical management of complicated retinal detachment in retinal hemangioblastoma.

Synopsis:

Systemic workup, diagnosis, and surgical steps in the management of complicated retinal detachment in retinal hemangioblastoma were performed.

Highlights:

Close follow-up, keen observation, and prompt treatment in the early stages of the disease are indispensable to prevent untoward sequelae of retinal hemangioblastoma. A thorough systemic workup is necessary to diagnose the systemic involvements early. Surgery, if indicated for the retinal hemangioblastoma or its associated sequelae, should be performed diligently and with careful handling of blood vessels and anomalous tissues.

Online Video Link:

https://youtu.be/CkoqWEnaPB8

Key words: Complicated retinal detachment, retinal hemangioblastoma, Von Hippel Lindau syndrome
Effects on ocular aberration and contrast sensitivity after implantation of spherical and aspherical monofocal intraocular lens - A comparative study
Authors: Deshpande Rahul , Satijia Anuj , Dole Kuldeep , Mangiraj Varsha , Deshpande Madan
Published: August 2022

Purpose:

Phacoemulsification with intraocular lens (IOL) implantation is the standard of care for cataractous eyes. Monofocal IOLs are spherical or aspheric. The aspheric design of IOLs reduces the spherical and higher-order aberrations and impacts contrast sensitivity post cataract surgery. There are some studies, but data in the Indian setting with the IOLs we used is lacking. We aimed to compare the effect of implantation of spheric and aspheric foldable intraocular lenses on postoperative quality of vision, spherical aberration, and contrast sensitivity.

Methods:

This prospective observational study was conducted at a tertiary care hospital with an ophthalmology specialty, data collection from January 2017 to May 2018 in 100 patients. Patients meeting the inclusion criteria were selected. Their preoperative and postoperative data were collected and divided into groups based on whether spherical or aspheric IOL was implanted after cataract surgery. Variables assessed were visual acuity on days 7 and 30, spherical aberrations, and contrast sensitivity was assessed at 1-month postoperative.

Results:

The mean age of the patients in this study was 64 ± 8 years with a majority of patients (60%) being females. There is no significant difference in postoperative visual acuity between the two groups. Internal SA was significantly lower (~50%) in eyes implanted with aspheric IOLs (P value = 0.004, 0.0001) compared with the spherical group. Contrast sensitivity of patients of the aspheric group was significantly better (P value <0.05).

Conclusion:

The optical design of the aspheric IOLs reduced spherical aberrations and increased contrast sensitivity.