bluuebunny/crossref_metadata_2025 huggingface dataset:
TATAR MUSLIM COMMUNITY OF ASTRAKHAN IN THE EARLY TWENTIETH CENTURY
Authors: Imasheva M. M.
Published: January 2019

The article discusses the main features of the Astrakhan Muslim community in the early twentieth century. During this period, Muslims of Russia entered the period of institutionalization of ethnic and religious identity. Astrakhan Muslim community in the period under review was one of the centers of the Muslim Tatar movement in the Russian Empire. At the same time, due to the historical and geographical features of the settlement of the Astrakhan region, the formation of the urban population of the provincial center, the community had a number of characteristic features that could not but aff ect all aspects of life of the mahalla. The work is based on the analysis of archival and published sources, works of local historians and orientalists. Unconditional numerical and material domination of the Tatar ethnic group became decisive in the development of the regional Muslim community. But at the same time, the factor of its polyethnicity had a great infl uence on various aspects of mahalla’s life. Even the Tatars, who formed the basis of the community, came from diff erent provinces and represented diff erent territorial groups of the Turkic-Tatar world. But as part of the Astrakhan Muslim community successfully managed to overcome the ethno-group interests, the isolation of local corporations. Islam has emerged as an integrating core value. Astrakhan mahalla has become an exceptional example of ethnic tolerance among co-religionists and loyalty to state institutions, on the other. Today, when the fl ow of migrants from the North Caucasus republics (primarily Dagestan and Chechnya) is directed to the Astrakhan region and the number of Muslims in the region increases annually, the experience of a century ago is very much in demand for the formation of a new religious identity here.
THE QATARI-TURKISH ALLIANCE AND SAUDI ARABIA: THE STRUGGLE OF ISLAMIST PROJECTS IN SYRIA
Authors: Khairullin T. R.
Published: January 2019

The article discusses Islamist projects promoted by Saudi Arabia and the Qatari-Turkish Alliance to strengthen their positions in Syria. The Saudis are focused on conservative Salafi Islamism, while Qatar and Turkey adhere to the moderate ideology of Islamism Muslim Brotherhood. Since the beginning of the crisis, the struggle between the competing forces has been unfolding within the opposition structures (the Syrian National Council, the National Coalition) and in the theater of operations, where there is a support for certain military formations loyal to ‘Pro-Saudi’ or ‘Pro-Qatari’ representatives of the opposition. The struggle of the Qatari-Turkish Alliance and Saudi Arabia has led to a signifi cant weakening of the positions of Qatar and Turkey in the negotiation process, however Doha and Ankara continue to maintain control over numerous armed groups of moderate persuasion.
‘ALI ‘ABD AL-RAZIQ AS FIRST SECULARIST THINKER IN ISLAM
Authors: Yefremova N. V.
Published: January 2019

The article deals with one of the most outstanding representatives of Muslim modernism but still has not been thoroughly studied in our country, Egyptian theologian ‘Ali ‘Abdarraziq (1888–1966), the author of a famous book ‘Islam and the Foundations of Political Power’ (1925).

The second part of the article analyses ‘Abdarraziq’s depoliticization of religion, his critics of the basic problems of traditional political theology of Islam: the conception of the Prophet Muhammad as a king in addition to his prophetic mission, the sacred necessity of the caliphate, the world Islamic government, etc.
Bosnia Herzegovina: un reflejo para la construcción del perdón en el conflicto de Colombia
Authors: Vásquez Santamaría Jorge Eduardo
Published: January 2019

El artículo acoge a Bosnia Herzegovina y a Colombia como casos de transición en los cuales se trata de pasar del conflicto a la construcción de la paz. Si bien ambos están caracterizados por similitudes que hacen de ellos experiencias de reflexión y aprendizaje, no sucede lo mismo con la configuración del perdón cuando se decreta la finalización del conflicto. A partir de una metodología cualitativa mediada por el enfoque histórico hermenéutico se realizó la revisión de narrativas plasmadas en crónicas con el objetivo de proponer una reflexión teórica del perdón. La reflexión permite evidenciar una mayor preponderancia la configuración del perdón en las narrativas literarias de la crónica colombiana como una iniciativa de las víctimas que se ha intensificado con el posacuerdo.
An efficient in vitro propagation protocol of Dianthus giganteiformis Borbas subsp. kladovanus (Degen) Soo
Authors: Markovic Marija , Grbic Mihailo , Djukic Matilda
Published: January 2019

Dianthus giganteiformis subsp. kladovanus is an endemic, endangered,
horticulturally appealing perennial plant that can be used for the
revegetation of sand dunes of the Danube region. The appropriate method for
its effective production is micropropagation. For this reason, the
experiments were conducted in order to establish an efficient protocol for
the micropropagation of this subspecies. The sterile culture was initiated
from seeds collected in situ and the germination percentage was high (88%).
According to the results obtained in this study, the multiplication phase
should be performed on an MS medium enriched with 0.1 mg/L BAP and 0.1 mg/L
NAA. The concentration of MS salts significantly influenced rooting, and
higher rooting percentages were obtained on reduced MS media (91.7 - 95%)
than on MS media (73.4 - 76.7%). The addition of NAA slightly increased
rooting percentage (up to 95%). Obtained microplants were successfully
acclimatized (83.3%) in a substrate composed of peat and sand (1: 1; v/v).
Using the protocol presented in this paper, the efficient propagation of D.
giganteiformis spp. kladovanus can be achieved for rapid plant production
aimed at revegetation, biodiversity protection and floricultural production
of this species.
Contribution to the interpretation of the role of geoenvironment in extreme discharges of the Rosomack River - Visok kraj
Authors: Nikic Zoran , Ristic Ratko , Maric Nenad , Milcanovic Vukasin
Published: January 2019

Annex to the interpretation of the role of geoenvironment in the formation of
extreme discharges of the Rosomacka River provides exact and empirical
evidence of the significance and the need for its knowledge. For
hydrologically unstudied watercourses, especially for those which do not have
continuity of discharges, the knowledge of the role of geoenvironment in the
emergence of their extreme discharges contributes to a more realistic
response to practical water management issues, protection against adverse
effects of waters, defining the ecological aspect of watercourses under the
influence of various changes in the near future (climatic, anthropogenic,
hydrological), preserving the quality of river water, meeting the
requirements of the EU Water Framework Directive 2000. The aim of the paper
is to understand better the river systems and their runoffs in the form of
high and low waters or complete drying up of hydrologically unstudied but
also of hydrologically studied watercourses, and through the representation
of the role of geoenvironment. On the concrete example of the Rosomacka
River, a hydrologically unstudied watercourse, the significance of
geoenvironment in the interpretation of its extreme discharges was
emphasized. The contribution of the following elements of geoenvironment of
the basin area was analyzed: lithological, neotectonic, hydrogeological and
morphological. The research method is based on field research, quantitative
geomorphological analysis, systematization and synthesis of the obtained
results, as well as the analysis of published papers. Additionally, the
contribution is reflected in emphasizing the need for communication between
experts of various specialties dealing with hydrographic systems.
Morphostructure relations on the territory of the Republic of Serbia
Authors: Menkovic Ljubomir , Koscal Milan , Milivojevic Milovan , Djokic Mrdjan
Published: January 2019

The paper presents author's views on morphostructural relations on the
territory of the Republic of Serbia, which are presented graphically in the
form of overview (reduced) morphostructural map in the scale of 1:2,000,000
to 1:2,500,000. The methodology of making morphostructural map, its content
and the way of data pre-sentation was considered. Special attention has been
paid to morphostructures, the determination of the origin and the difference
between structural, morphostructural and morphosculpture relief forms. A
brief overview of the geological structure, as well as the geomorphological
characteristics of geotectonic, i.e. morphostructural units, is given.
Finally, the geomorphological history, morphogenesis and the evolution of
the relief of Serbia, from the beginning of the Miocene to the present is
presented.
Valorization of cultural tourist values of the city core of Nis according to the Hilary Du Cros Model
Authors: Milenkovic Jelena
Published: January 2019

Cultural tourism integrates the culture and tourism sector, whereby mutual
benefits can be achieved. In order to reflect favorable conditions in both
sectors, it is necessary to approach the planning and transformation of
cultural and historical heritage into a cultural-tourist product. The initial
phase in planning is the valorization of cultural tourist values. Hilary Du
Cros Model was created especially for the valorization of cultural tourist
values. The model is complex because it evaluates the cultural-tourist
sub-indicators and the degree of their gradation, separately for the tourism
sector and the sector of heritage asset management. The aim of the paper is
to evaluate the tourism sector and the sector of the management of
representative cultural assets of the city core of Nis according to the Model
Hilary Du Cros. After the analysis of sub-indicators, the city core of Nis
was awarded a cell M (2,3), which points to favorable conditions for the
development of cultural tourism, but it is necessary to approach more
responsible planning of cultural tourist values.
Separate and Combined Glucometabolic Effects of Endogenous Glucose-Dependent Insulinotropic Polypeptide and Glucagon-like Peptide 1 in Healthy Individuals
Authors: Gasbjerg Lærke S. , Helsted Mads M. , Hartmann Bolette , Jensen Mette H. , Gabe Maria B.N. , Sparre-Ulrich Alexander H. , Veedfald Simon , Stensen Signe , Lanng Amalie R. , Bergmann Natasha C. , Christensen Mikkel B. , Vilsbøll Tina , Holst Jens J. , Rosenkilde Mette M. , Knop Filip K.
Published: January 2019

The incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are secreted postprandially and contribute importantly to postprandial glucose tolerance. In this study, we assessed the individual and combined contributions of endogenous GIP and GLP-1 to the postprandial changes in glucose and glucoregulatory hormones using the novel GIP receptor antagonist GIP(3-30)NH2 and the well-established GLP-1 receptor antagonist exendin(9-39)NH2. During 4-h oral glucose tolerance tests (75 g) combined with an ad libitum meal test, 18 healthy men received on four separate days in randomized, double-blinded order intravenous infusions of A) GIP(3-30)NH2 (800 pmol/kg/min) plus exendin(9-39)NH2 (0–20 min: 1,000 pmol/kg/min; 20–240 min: 450 pmol/kg/min), B) GIP(3-30)NH2, C) exendin(9-39)NH2, and D) saline, respectively. Glucose excursions were significantly higher during A than during B, C, and D, while glucose excursions during B were higher than during C and D. Insulin secretion (assessed by C-peptide/glucose ratio) was reduced by 37 ± 16% (A), 30 ± 17% (B), and 8.6 ± 16% (C) compared with D (mean ± SD). A and C resulted in higher glucagon levels and faster gastric emptying. In conclusion, endogenous GIP affects postprandial plasma glucose excursions and insulin secretion more than endogenous GLP-1, but the hormones contribute additively to postprandial glucose regulation in healthy individuals.
In Vitro Red Fluorescence as an Indicator of Caries Lesion Activity
Authors: Kim BR , Kang SM , de Josselin de Jong E , Kwon HK , Kim BI
Published: January 2019

This in vitro study examined the utility of comparing red fluorescence between active and inactive caries lesions and investigated whether changes in red fluorescence and fluorescence loss are influenced by lesion activity following remineralization. Sixty-two noncavitated smooth surface caries lesions on extracted human teeth were classified into active or inactive lesions using the Nyvad system prior to a 12-day pH-cycling procedure. Quantitative light-induced fluorescence-digital images were used to measure fluorescence parameters before and after pH cycling. At baseline, the intensity (ΔR) and area (AΔR) of red fluorescence were 1.5- and 2.2-fold higher in active lesions than in inactive lesions (p<0.05). The ratio of AΔR to lesion area was associated with classification of active lesions (odds ratio = 1.031; 95% confidence interval = 1.005–1.058). After pH cycling, the active lesions showed about 2- and 8-fold greater reductions in the median values of AΔR and fluorescence loss related to lesion volume (ΔQ) compared with inactive lesions (p<0.05). In conclusion, red fluorescence differs depending on lesion activity, and the red fluorescence area and lesion volume change following remineralization. The results suggest that measuring red fluorescence may be a useful way of objectively evaluating lesion activity of smooth surface lesions.
APLIKASI PENJADWALAN MATA PELAJARAN DI SMAN 31 MENGGUNAKAN ALGORITMA GENETIKA BERBASIS WEB
Authors: Ivan Ivan , Raphael Stephanus , Agung Halim
Published: January 2019

Sekolah Menengah Atas Negeri 31 memiliki kelas sebanyak 29 kelas yang masing-masing memiliki 3 jurusan yaitu IPA, IPS dan Bahasa. Masing masing jurusan memiliki jumlah kelas yang cukup banyak. Sehingga pembuatan jadwal mata pelajaran oleh pihak sekolah memerlukan waktu yang cukup lama dan menggangu kelancaran proses belajar dan mengajar. aplikasi penjadwalan mata pelajaran menggunakan algoritma genetika merupakan solusi yang tepat untuk SMAN31. Algoritma Genetika adalah Proses seleksi alamiah yang melibatkan perubahan gen yang terjadi pada individu melalui proses perkembang-biakan yang menjadi proses dasar dan menjadi perhatian utama. Metode pengembangan sistem yang digunakan dalam penelitian ini adalah Metode Waterfall. Hasil dari penelitian ini adalah aplikasi penjadwalan SMAN 31 Jakarta yang dapat menyusun jadwal yang baik secara otomatis. Kesimpulan dari penelitian ini adalah algoritma genetika dapat diimplementasikan pada aplikasi penjadwalan dibuktikan dengan menguji 30 contoh jadwal yang tersusun oleh aplikasi tanpa ada yang bertabrakan satu sama lain. Kata kunci: SMAN31, algoritma, penjadwalan, genetika, populasi.
PERBAIKAN PROSES PRODUKSI DENGAN STANDAR CARA PRODUKSI PANGAN YANG BAIK (CPPB) DAN WORK IMPROVEMENT IN SMALL ENTERPRISE (WISE) PADA INDUSTRI KERUPUK SALA
Authors: Suhardi Bambang , Kadita Maria , Laksono Pringgo Widyo
Published: January 2019

Kerupuk merupakan makanan kering khas Indonesia yang terbuat dari bahan dasar tepung tapioka dan sudah sangat dikenal oleh masyarakat. Industri kerupuk yang banyak tersebar di wilayah Indonesia sebagian besar masih merupakan Industri Rumah Tangga (IRT) yang proses produksinya dikerjakan secara tradisional. Setiap industri rumah tangga yang menghasilkan olahan pangan wajib memiliki SPP-IRT (Sertifikat Produksi Pangan Industri Rumah Tangga). SPP-IRT diperlukan oleh pelaku IRT agar dapat memperluas pasar penjualan dan memasuki pasar ritel modern. Untuk mendapatkan SPP-IRT terdapat beberapa aspek yang dinilai sesuai dengan peraturan CPPB (Cara Produksi Pangan yang Baik) yang diatur oleh BPOM. Penelitian ini bertujuan untuk mengevaluasi penerapan CPPB pada IRT kerupuk SALA dengan menggunakan daftar periksa CPPB-WISE sebagai upaya perbaikan proses produksi dan pemenuhan standar untuk mendapatkan SPP-IRT. Penelitian ini terdiri dari tujuh tahap yaitu identifikasi kondisi di kerupuk SALA, pemeriksaan daftar periksa CPPB di industri kerupuk SALA, pemeriksaan daftar periksa WISE di industri kerupuk SALA, penyusunan daftar periksa CPPB-WISE, pembobotan kriteria dan subkriteria daftar periksa CPPB-WISE dengan metode AHP, rekapitulasi pembobotan daftar periksa CPPB –WISE, dan usulan alternatif perbaikan proses produksi. Berdasarkan hasil penelitian dapat disimpulkan bahwa terdapat lima kriteria yang menjadi prioritas perbaikan berdasarkan evaluasi penilaian daftar periksa GMP-WISE dan juga diberikan usulan berupa penerapan budaya kerja 5S (Seiri, Seiton, Seiso, Seiketsu, dan Shitsuke) di IRT kerupuk SALA.
PENERAPAN APLIKASI SISTEM INFORMASI KEPENDUDUKAN BERBASIS WEB PADA KANTOR KEPALA DESA PUPUT KEC. SIMPANGKATIS
Authors: Sujono Sujono
Published: January 2019

Kantor Kepala Desa Puput merupakan salah  satu  Kantor Kepala Desa  di Kecamatan Simpangkatis Kabupaten Bangka Tengah yang memiliki peran penting dalam perkembangan teknologi di lembaga pemerintahan. Perkembangan teknologi sistem informasi dengan penggunaan komputer dapat menghasilkan pengolahan data yang cepat, tepat dan akurat sehingga lebih efektif dan efisien. Sistem informasi kependudukan yang diperlukan seperti Formulir Permohonan KK, Surat Keterangan Kelahiran, Kematian, Pindah Jiwa, Pindah Datang dan Formulir E-KTP yang sangat diperlukan keakuratan dan ketelitian dalam pendataannya. Permasalahan yang sering terjadi di Kantor Kepala Desa Puput dikarenakan belum adanya sistem kependudukan sehingga pengolahan data kependudukannya masih secara manual yang akan memperlambat kinerja pada instansi tersebut. Media penyimpanan data kependudukannya pun masih menggunakan dokumen-dokumen sehingga rentan kehilangan atau kerusakan data. Sering terjadinya pengulangan data kependudukan dikarenakan tidak adanya pendataan yang telah tersistem. Berdasarkan permasalahan tersebut, dibuatlah sistem kependudukan berbasis web   dengan tujuan agar dapat mempermudah pendataan dan pengolahan data penduduk pada Kantor Kepala Desa Puput serta mengurangi kesalahan dalam penyajian data dan mempermudah dalam menghasilkan laporan kependudukan. Untuk merancang dan  menganalisa sistem manual sehingga menjadi sistem terkomputerisasi menggunakan metodologi Analisis berorientasi obyek(Object-Oriented Analisis). Dari analisa dan perancangan yang sudah disesuaikan dengan kebutuhan di Kantor Kepala Desa di Kecamatan Simpangkatis menghasilkan sebuah aplikasi berbasis web yang dapat mengatasi masalah yang ada. Kata kunci: kependudukan,aplikasi, sistem informasi, berbasis web.
Serum C-C motif ligand 11/eotaxin-1 may serve as a candidate biomarker for postmenopausal osteoporosis
Authors: Wang Wen , Huang Ci-You , Wang Zhuo-Ping , Xu Shan-Shan , Qian Tie-Yong , Chen Yi-Ding , Wu Wei-Guo
Published: January 2019

Background

The chemokine C-C motif ligand 11, also known as eotaxin-1, has been identified as a novel mediator of inflammatory bone resorption. However, little is known regarding a potential role for CCL11/Eotaxin-1 in postmenopausal osteoporosis.

Objective

The scope of this study was to explore the relationship between serum CCL11/Eotaxin-1 concentrations and disease progression of postmenopausal females with osteoporosis.

Methods

A total of 83 postmenopausal women diagnosed with osteoporosis were enrolled. Meanwhile, 82 postmenopausal women with normal bone mineral density (BMD) and 85 healthy controls inner child-bearing age were enrolled as control. The Dual-energy X-ray absorptiometry was used to examine the BMDs at the femoral neck, lumbar spine 1-4 and total hip of all participants. Serum CCL11/Eotaxin-1 levels were examined by enzyme-linked immunosorbent assay. We also included inflammation marker interleukin-6 (IL-6) as well as a serum marker of bone resorption C-telopeptide cross-linked collagen type 1 (CTX-1). The Visual Analogue Scale (VAS) and Oswestry Disability Index (ODI) were recorded to evaluate the clinical severity in POMP females.

Results

Serum CCL11/Eotaxin-1 levels were significantly elevated in postmenopausal osteoporotic patients PMOP patients compared with PMNOP and healthy controls. We observed a significant negative correlation of serum CCL11/Eotaxin-1 levels with lumbar spine, femoral neck and total hip BMD. Furthermore, serum CCL11/ Eotaxin-1 concentrations were also positively related to the VAS and ODI scores. Last, serum CCL11/ Eotaxin-1 concentrations were positively associated with IL-6 and CTX-1 levels. These correlations remain significant after adjusting for age and BMI. Multivariate linear regression analysis demonstrated that CCL11/Eotaxin-1 could serve as an independent marker.

Conclusions

Serum CCL 11/Eotaxin-1 may serve as a candidate biomarker for postmenopausal osteoporosis. Therapeutics targeting CCL11/Eotaxin-1 and its related signalling way to prevent and slow progression of PMOP deserve further study.
Optical properties of AlN layers obtained by magnetron sputtering
Authors: Potera Piotr , Wisz Grzegorz , Szyller Łukasz
Published: January 2019

The growth of AlN layers on glass substrates using magnetron sputtering method was performed and the grown layers were subjected to optical measurements. Transmission spectra of the layers grown at different content of N2 in the atmosphere were obtained. The transmission spectra as well as energy gap depended on N2 content. The annealing of the layers in air led to transmission changes and influenced energy gap and refractive index values.
Synthesis of multi-walled carbon nanotubes with controlled inner and outer diameters by ethylene decomposition over Ni/MgO and Co/MgO catalysts
Authors: Lemesh N.V. , Strizhak P.E.
Published: January 2019

In this work, multi-walled carbon nanotubes (MWCNTs) with significantly different mean diameters were produced by catalytic CVD over Ni and Co-based supported catalysts. Our results indicate that Ni nanoparticles in the Ni/MgO catalyst are responsible for controlling the inner diameters of the carbon nanotubes. Contrary, Co nanoparticles in the Co/MgO catalyst control the outer diameters of MWCNTs. The “base-growth” mechanism and smaller diameters of the MWCNTs grown on the Ni/MgO catalyst are associated with a strong metal-support interaction (SMSI) resulting from NixMg1−xO mixed oxide formation. The concept of the weak metal-support interaction (WMSI) between Co nanoparticles and MgO for the Co/MgO catalyst confirms the “tip-growth” mechanism of the MWCNTs.
Vascular Access Failure - Cause or Complication of Central Venous Catheterization: Case Report
Authors: Zornic Nenad , Zunic Filip , Stolic Radojica , Spasic Marko , Radmanovic Branislav , Nesic Jelena
Published: January 2019

The quality of life and patient survival rate in terminal chronic renal insufficiency depends on the duration of vascular approaches. Dialysis catheters are used to establish an adequate vascular approach when emergency hemodialysis is indicated and when all approaches are exhausted. Complications of CVC can be classified into three categories: mechanical (hematoma, arterial puncture, pneumothorax, hemothorax, catheter misplacement, and stenosis), infectious (insertion site infection, CVC colonization, and bloodstream infection) and thrombotic (deep vein thrombosis). Despite the increasing prevalence of haemodialysis patients with complex access issues, there remains no consensus on the definition of vascular access failure or end-stage vascular access. The dilema in these cases remains whether the generalized vascular insufficiency is the cause or a complication of exhausted vascular accesses. This case report is one of the examples of combined complications with generalized vascular access insufficiency. During the year and a half of the chronic dialysis program, the patient had several changes of vascular approaches, and each approach became dysfunctional in certain time due to various causes. After six months of successful hemodialysis, the patient was admitted with signs of infection and during hospitalization was again subjected to multiple changes of the vascular approach due to infection, thrombosis, and vascular access failure.
The Role of Tumor Microenvironment and Impact of Cancer Stem Cells on Breast Cancer Progression and Growth
Authors: Markovic Nenad , Lukovic Ana , Arsenijevic Nebojsa , Ninkovic Srdjan , Ljujic Biljana
Published: January 2019

Breast cancer is not only a mass of genetically abnormal tissue in the breast. This is a well-organized system of a complex heterogeneous tissue. Cancer cells produce regulatory signals that stimulate stromal cells to proliferate and migrate; then, stromal elements respond to these signals by releasing components necessary for tumor development that provide structural support, vasculature, and extracellular matrices. Developing tumors can mobilize a variety of cell types from both local and distant niches via secret chemical factors derived from cancer cells themselves or neighboring cells disrupted by growing neo-plasm, such as fibroblasts, immune inflammatory cells, and endothelial cells. CSCs are a group of very few cells that are tumorigenic (able to form tumors) and are defined as those cells within a tumor that can selfrenew and lead to tumorigenesis. BCSCs represent a small population of cells that have stem cell characteristics and are related to breast cancer. There are different theories about the origin of BCSCs. BCSCs are responsible for breast carcinoma metastasis. Usually, there is a metastatic spread to the bones, and rarely to the lungs and liver. A phenomenon that allows BCSCs to make the transition from epithelial to mesenchymal expression and thus avoid the effect of cyto toxic agents is the epithelial-mesenchymal transition (EMT). During this process, cells change their molecular characteristics in terms of loss of epithelial characteristics taking the mesenchymal phenotype. This process plays a key role in the progression, invasion, and metastasis of breast tumors.
Antiapoptotic Proteins mcl-1 and bcl-2 as well as Growth Factors FGF and VEGF Influence Survival of Peripheral Blood and Bone Marrow Chronic Lymphocytic Leukemia Cells
Authors: Djurdjevic Predrag , Jovanovic Danijela , Baskic Dejan , Popovic Suzana
Published: January 2019

Apoptosis inhibition in chronic lymphocytic leukemia (CLL) is one of the most important mechanism in the disease onset, progression and therapy response and is dependent of interaction with different microenvironments.

Aim of our paper is to determine expression of antiapoptoic proteins mcl-1 and bcl-2 in CLL cells isolated from two different compartments (peripheral blood and bone marrow) and its relation to percent of apoptotic cells and concentration of growth factors (FGF and VEGF).

Our results showed that peripheral blood CLL lymphocytes have lower apoptotic rate then those isolated from bone marrow, though bone marrow CLL lymphocytes express higher levels of antipoptotic proteins bcl-2 and mcl-1. In bone marrow FGF concentration is 10-fold higher then in patients plasma but has an limited impact on mcl-1 expression. In contrary, VEGF concentration is higher in peripheral blood and corelate with percent of apoptotic cells and mcl-1 expression in this compartment.

CLL cells derived from two different microenvironmets acts differently when tested for apoptosis „ex vivo“. In peripheral blood apoptosis is strongly connected with expression of antiapoptoic proteins (mcl-1 and bcl-2) and growth factors, but not in bone marrow.
Galectin-3 in Critically Ill Patients with Sepsis and/or Trauma: A Good Predictor of Outcome or Not?
Authors: Jevdjic Jasna , Surbatovic Maja , Milosavljevic Snezana , Rondovic Goran , Stanojevic Ivan , Eric Stevan , Zornic Nenad
Published: January 2019

Severe sepsis and/or trauma complicated with multiple organ dysfunction syndrome are leading causes of death in critically ill patients. The aim of this prospective, observational, single centre study was to assess the prognostic value of galectin-3 regarding outcome in critically ill patients with severe trauma and/or severe sepsis. The outcome measure was hospital mortality.

In total, 75 critically ill patients who were admitted to the intensive care unit of the tertiary university hospital were enrolled in a prospective observational study. Blood samples were collected upon fulfilling Sepsis-3 criteria and for a traumatized Injury Severity Score > 25 points.

Levels of galectin-3 were significantly higher in nonsurvivors on the day of enrolment – Day 1 (p<0.05). On Day 1, the area under the curve (AUC) for the galectin-3 for lethal outcome was 0.602. At a cut-off level of 262.82 ng/mL, the sensitivity was 53%, and the specificity was 69.7%, which was objectively determined by a Youden index of 0.20.

The discriminative power of galectin-3 in predicting outcome was statistically significant. Galectin-3 on Day 1 is a fairly good predictor of lethal outcome.
The Importance of Physical Therapy in the Treatment of Unilateral Congenital Bell Paralysis – A Case Report
Authors: Milosevic Jelena , Pavicevic Danijela , Parezanovic-Ilic Katarina , Milenkovic Zoran
Published: January 2019

Peripheral paralysis of facial nerve in the newly-born can be congenital and developed. In clinical sense, paralysis of facial nerve is characterised by paralysis of mimic face muscles that are controlled by a facial nerve. A female newly-born, delivered by caesarean section was clinically diagnosed weakness on the right side of the face. Thirteen days after the birth the newly-born was examined by a physiatrist for the first time due to the weakness of the right facial side. During the first year of life a severe congenital lesion of facial nerve was diagnosed. Rehabilitation treatments were administered during the first year of life, with partial clinical improvement. The seriousness of facial nerve lesion hasa significant influence on the degree of recovery. It is very important to identify the type of lesion by using efficient technology, since it is the only way to provide early and adequate therapy
Overview of Deep Learning Models in Biomedical Domain with the Help of R Statistical Software
Authors: Renganathan Vinaitheerthan
Published: January 2019

With the increase in volume of data and presence of structured and unstructured data in the biomedical filed, there is a need for building models which can handle complex & non-linear relations in the data and also predict and classify outcomes with higher accuracy. Deep learning models are one of such models which can handle complex and nonlinear data and are being increasingly used in the biomedical filed in the recent years. Deep learning methodology evolved from artificial neural networks which process the input data through multiple hidden layers with higher level of abstraction. Deep Learning networks are used in various fields such as image processing, speech recognition, fraud deduction, classification and prediction. Objectives of this paper is to provide an overview of Deep Learning Models and its application in the biomedical domain using R Statistical software Deep Learning concepts are illustrated by using the R statistical software package. X-ray Images from NIH datasets used to explain the prediction accuracy of the deep learning models. Deep Learning models helped to classify the outcomes under study with 91% accuracy. The paper provided an overview of Deep Learning Models, its types, its application in biomedical domain. - is paper has shown the effect of deep learning network in classifying images into normal and disease with 91% accuracy with help of the R statistical package.
Bcl-2 Family Overexpression and Chemoresistance in Acute Myeloid Leukemia
Authors: de Melo Silva Alex José
Published: January 2019

The family of Bcl-2 proteins is one of the most responsible for apoptosis pathway, that is a critical process to the maintenance of tissue homeostasis. Bcl-2 is an essential apoptotic regulator belonging to a family of functionally and structurally related proteins known as the Bcl-2 family. Some members of this family act as anti-apoptotic regulators, whereas others act in pro-apoptotic function. The relationship between the pro and anti-apoptotic proteins can regulate whether cells begin the apoptosis or remain its life cycle. Increasing of Bcl-2 expression has been found in some hematologic diseases, such as Acute Myeloid Leukemia (AML) and their effects on responsiveness to anticancer therapy have been recently described. Thus, this review aims to discuss apoptosis and the role of the Bcl-2 family of proteins in chemoresistance when overexpressed in patients committed with Acute Myeloid Leukemia submitted to chemotherapy treatment.
The Study of Current-Voltage (I-V) Characteristic Curve of Chitosan-Silver Nanoparticle Composite Membrane
Authors: Islami Maulida Nirwana , Rupiasih Ni Nyoman , Sumadiyasa Made , Sujana Manuaba I B
Published: January 2019

A study of the current-voltage (I-V) curve of the chitosan-silver nanoparticle composite membrane (Ch-AgNP) has been conducted. Membranes were prepared by casting method using chitosan as matrix, acetic acid 1% as solvent and silver nanoparticle (AgNP) as filler. AgNP used was 100 ?g. As a comparison is a pure chitosan membrane (membrane Ch). The I-V measurement was performed using a cell model consisting of 2 chambers, chambers 1 and 2. The voltage (V) was measured using Ag/AgCl calomel electrode in electrolyte solution of KCl and CaCl2 with concentration of 0.025 M. All measurements were done at room temperature ± 28 0C. The result shows that in the current range 0.66-0.98 mA, the I-V curve of the Ch-AgNP membrane is ohmic. The conduction value of the composite membrane is smaller than that of the chitosan membrane and the value is greater in the KCl solution than in CaCl2 solution.
Analysis of Changes in Area of Mangrove Density at Ngurah Rai Bali Grand Forest Park Using Image of Landsat 8 Satellite
Authors: Darmo Kadek , Suarbawa Komang Ngurah , Widagda I Gusti Agung
Published: January 2019

The study is report about to estimate the change of mangrove density level of Ngurah Rai Bali Forest Park from 2014 until 2017 using image of Landsat satellite 8 which was processed with ArcGis software. The density level was determined by using the NDVI method and grouped according to the NDVI range according to the Ministry of Forestry’s rules of 2005. The result shows that in the rare area, the change in the area of density reduced by 23.67 ha, in medium area decreased by 16.74 ha, in the tight area increased by 24.3 ha, and in the total area of mangrove reduced by 16.11 ha. Those results obtained with accuracy of 100 %, 67 %, 93% and 90 % in rare area, medium area, tight area and total area, respectively.
PENGARUH KETERLIBATAN KERJA, IKLIM ORGANISASI, DAN KEPUASAN KERJA TERHADAP KOMITMEN ORGANISASIONAL
Authors: Ariana I Gde Raka , Mujiati Ni Wayan
Published: January 2019

Komitmen organisasional merupakan suatu keinginan yang dimiliki oleh anggota organisasi untuk tetap bertahan dalam organisasi dan salah satu faktor penting yang dapat memberikan kontribusi terhadap pencapaian tujuan organisasi. Penelitian ini bertujuan untuk mengetahui pengaruh signifikan dari keterlibatan kerja, iklim organisasi, dan kepuasan kerja terhadap komitmen organisasional karyawan restoran ingka di Kerobokan.

Penelitian ini dilakukan pada restoran ingka di Kerobokan. Jenis data yang digunakan adalah data kualitatif yang bersumber dari gambaran umum restoran dan data kuantitatif adalah jumlah karyawan restoran ingka. Jumlah responden sebanyak 45 karyawan. Pengumpulan data menggunakan metode observasi, wawancara dan kuesioner. Teknik analisis data yang digunakan adalah analisis regresi linier berganda.

Berdasarkan hasil analisis ditemukan bahwa keterlibatan kerja berpengaruh positif dan signifikan terhadap komitmen organisasional, iklim organisasi berpengaruh positif dan signifikan terhadap komitmen organisasional, dan kepuasan kerja berpengaruh positif dan signifikan terhadap komitmen organisasional.
PENGARUH GENDER, DAYA TARIK PROMOSI, KEPEMILIKAN KARTU KREDIT TERHADAP PERILAKU PEMBELIAN IMPULSIF ONLINE PRODUK LIFESTYLE
Authors: Putra Made Santika , Santika I Wayan
Published: January 2019

Technological advances create a new paradigm in the business world. The rapid development of internet usage will have a positive impact for online business in Indonesia. One of the most desirable consumer behavior by marketers who use online media is the impulsive purchase behavior. This study aims to determine the effect of gender, attractiveness of promotion and ownership of credit cards against impulsive buying behavior online. This research was conducted in Denpasar City involving 60 respondents through purposive sampling method. This method was chosen because it is not known exactly the number of population. Data were collected through questionnaires. Data analysis technique used is multiple linear regression analysis technique.The results of this study found that gender positively and positively affects online impulsive buying behavior, promotional appeal positively and significantly affects online impulsive buying behavior and credit card ownership positively and significantly affects online impulsive buying behavior. Marketers are expected to be more accurate in determining market segmentation, more creative in promoting and able to provide convenience and convenience in the payment process when shopping online.

Keywords: gender, attraction of promotion, credit card ownership, impulsive buying behavior.
PENGARUH CITRA MEREK, KUALITAS PRODUK DAN PERSEPSI HARGA TERHADAP KEPUASAN DAN NIAT BELI ULANG
Authors: Savitri Ida Ayu Putu Dian , Wardana I Made
Published: January 2019

Repeat intention is one of the important factors for the company. The re-purchase intention of a product arises because the consumer is satisfied with the product purchased previously. One of the keys in creating a buy-back intention is to increase customer satisfaction. This research was conducted in Denpasar City involving 120 respondents. The purposive sampling method is chosen as the method of data collection. Data collection was done by distributing questionnaires containing statements relating to brand image variables, product quality, price perceptions, customer satisfaction and re-purchase intentions. Furthermore, data from the results of collecting the questionnaire is processed by using the validity test, and reliability test to determine the feasibility and consistency of indicators in the questionnaire. In addition to the validity test and reliability test, another test is performed path analysis. The results of this study found that, brand image, product quality and price perception have a positive and significant impact on customer satisfaction. Brand image is the most dominant variable affecting customer satisfaction. Customer satisfaction also has a positive and significant impact on repurchase intentions. So it can be concluded that creating the intention to buy back on consumers can be done by increasing customer satisfaction.
PENGARUH PROFITABILITAS, RISIKO KREDIT, LIKUIDITAS, DAN EFISIENSI OPERASIONAL TERHADAP KECUKUPAN MODAL PADA BPR KABUPATEN KLUNGKUNG
Authors: Agustini Ni Putu Ayu Ria , Wardana I Made
Published: January 2019

ABSTRAK

Penelitian ini bertujuan untuk mengetahui pengaruh profitabilitas, risiko kredit, likuiditas dan efisiensi operasional terhadap kecukupan modal pada Bank Perkreditan Rakyat Kabupaten Klungkung pada tahun 2013 – 2017. Dalam penelitian ini metode yang digunakan adalah teknik analisis regresi linier berganda. Penelitian ini menggunakan sampel jenuh dengan total sampel sebanyak 5 BPR yang terletak di Kabupaten Klungkung. Berdasarkan hasil analisis yang telah dilakukan, didapat hasil yakni Profitabilitas yang diwakilkan oleh ROA,  risiko kredit yang diwakilkan oleh NPL, likuiditas yang diwakilkan oleh LDR, dan efisiensi operasional yang diwakilkan oleh BOPO mendapatkan hasil positif signifikan terhadap kecukupan modal. 76,4 persen kecukupan modal dipengaruhi oleh profitabilitas, risiko kredit, likuiditas dan efisiensi operasional sedangkan sisanya sebesar 23,6 persen dipengaruhi oleh faktor-faktor lain yang tidak dimasukkan kedalam model penelitian.

Kata kunci : ROA, NPL, LDR, BOPO, kecukupan modal
PENGARUH GREEN PERCEIVED VALUE TERHADAP GREEN REPURCHASE INTENTION YANG DIMEDIASI OLEH GREEN TRUST
Authors: Sudita Ni Putu Candradita Revita , Ekawati Ni Wayan
Published: January 2019

Environmental issues have been increasingly recognized by the public with the rise of news about global warming. This encourages consumers to better appreciate environmentally friendly products. This study aims to explain the effect of green perceived value on green repurchase intention mediated by green trust products of The Body Shop in Denpasar city. The number of samples in this study were 120 respondents by using purposive sampling technique. The analysis technique used in this research is path analysis technique. Based on the analysis result, it was found that green perceived value had positive and significant effect on green repurchase intention. Green perceived value has a positive and significant effect on green trust. Green trusts have a positive and significant influence on green repurchase intention. Green trusts significantly mediate the effect of green perceived value on green repurchase intention. The Body Shop should be more intensive in providing information about the benefits derived from using the product and must further improve the quality and quality of the product.

 

Keywords: Green Marketing, green perceived value, green trust, green repurchase intention.
PENGARUH SPREAD TINGKAT SUKU BUNGA, NON PERFORMING LOAN, DAN BOPO TERHADAP PROFITABILITAS
Authors: Ekadini Badung Ida I Dewa Ayu , Yadnya I Putu
Published: January 2019

The purpose of this study is to determine the effect of Spread Rate of Interest Rate, NPL and BOPO on Profitability of Rural Banks in Denpasar period 2014-2016. This research uses non participant observation method with the sample used as many as 19 BPR in Denpasar City. Data analysis technique used multiple linear regression analysis. The results of this study show that partially positive Spread has no significant effect on Return On Assets (ROA) on BPR in Denpasar City 2014-2016. Non Performing Loan (NPL) has a significant negative effect on ROA in BPR in Denpasar City 2014-2016. Operational Costs to Operating Income (BOPO) have a significant negative effect on ROA in BPR in Denpasar City 2014-2016. The implications of this study the higher Spread ratio will increase the ROA of banking companies. While the NPL and BOPO the higher the ratio of these variables, then the ROA of banking companies will decrease, so to improve the ROA of banking companies have to press NPL and utilize existing sources and systems.

Keywords: Interest Rate Spread, NPL, BOPO, Profitability.
PENGARUH IKLIM ORGANISASI, DISIPLIN KERJA DAN KEPEMIMPINAN TERHADAP KEPUASAN KERJA PEGAWAI DISNAKER DAN ESDM BALI
Authors: Saridewi Ni Kadek Novi , Adnyani I Gusti Ayu Dewi
Published: January 2019

The purpose of this study is to analyze the influence of organizational climate, work discipline, and leadership on job satisfaction of the employees of the Office of Manpower and Energy of Mineral Resources of Bali Province. The population of this study is all permanent employees of the Office of Manpower and Energy Mineral Resources of Bali Province. Sampling in this study used a saturated or census sample technique, in which the entire study population will be selected to be sampled. The total number of permanent employees of the Department of Manpower and Energy of Mineral Resources of Bali Province is 75 people, so the number of samples used in this research is 75 people. The data collected in this study were analyzed using multiple linear regression. The result of the analysis shows that organization climate, work discipline, and leadership have positive and significant influence to the job satisfaction of the employee of the Department of Manpower and Energy of Mineral Resources of Bali Province. The better the organizational climate, the higher the attitude of employee discipline and the better the leadership in the Office of Manpower and Energy Mineral Resources of Bali Province will further increase job satisfaction perceived employee
PREDIKSI KONDISI KEUANGAN PADA PERUSAHAAN SEKTOR PERTAMBANGAN DI BURSA EFEK INDONESIA
Authors: Rasminiati Ni Kadek Tina , Artini Luh Gede Sri
Published: January 2019

Kondisi keuangan merupakan suatu keadaan yang menunjukkan tingkat kesehatan perusahaan yang sesungguhnya. Kondisi keuangan diukur dengan melihat perusahaan yang mengalami financial distress dan perusahaan yang tidak mengalami financial distress. Tujuan penelitian adalah mengetahui pengaruh dari rasio keuangan seperti current asset turnover, total asset turnover, days sales in receivables, cash flow to total debt, dan  debt to asset terhadap  financial distress. Penelitian dilakukan pada perusahaan sektor pertambangan di BEI periode 2012-2016. Jumlah sampel penelitian yaitu sebanyak 8 perusahaan dalam kategori mengalami financial distress dan 16 perusahaan dalam kategori tidak mengalami financial distress. Metode pengumpulan data menggunakan metode observasi nonparatisipan dan regresi logistik sebagai teknik analisis data. Hasil penelitian ini menemukan bahwa: current asset turnover memiliki pengaruh negatif tidak signifikan terhadap financial distress, total asset turnover berpengaruh negatif signifikan terhadap financial distress, days sales in receivables memiliki pengaruh positif tidak signifikan terhadap financial distress, cash flow to total debt memiliki pengaruh negatif tidak signifikan terhadap financial distress, dan debt to asset berpengaruh berpengaruh positif signifikan terhadap financial distress.

Kata kunci : kondisi keuangan, financial distress, dan rasio keuangan.
PENGARUH NPL, CAR DAN BOPO TERHADAP PROFITABILITAS PADA BPR DI KOTA DENPASAR
Authors: Putri Ni Kadek Alit Pradina , Wiagustini Luh Putu , Abundanti Ni Nyoman
Published: January 2019

BPR financial performance can be measured by the community through analysis of financial statements. An analysis of the financial statements of a bank is conducted to determine the level of profitability and soundness of the bank. The purpose of this research is to know the influence of Non Perfoming Loan, Capital Adequacy Ratio and Operational Cost of Operational Revenue to profitability at Rural Bank in Denpasar in period 2013-2016. The method used in this research is multiple regression analysis technique. This research uses saturated samples by taking samples of 18 existing BPR in Denpasar City. Based on the results of the analysis found that Non Perfoming Loan has a significant negative effect on profitability, Capital Adequacy Ratio has a significant positive effect on profitability, and operational cost of operating income has a significant negative effect on profitability.

Keywords: npl, car, bopo, profitability
PENGARUH KEPEMIMPINAN, PEMBERDAYAAN KARYAWAN DAN KEPUASAN KERJA TERHADAP KOMITMEN ORGANISASI PADA HOTEL KLAPA RESORT PECATU
Authors: Dwi Putra Bagus Indra , Suana I Wayan
Published: January 2019

The purpose of this study is to determine the influence of leadership, employee empowerment, and job satisfaction of organizational commitment. This research was conducted at Hotel Klapa Resort Pecatu. The number of population taken as many as 60 people, in this study the method of determining the sample used is the census. Data collection is done through primary data in the form of questionnaires and interviews. Analytical techniques conducted in this study using multiple linear regression method using independent variables of leadership, employee empowerment, and job satisfaction. Based on the results of research can be concluded that leadership has a positive and significant effect. Employee empowerment has positive and significant impact to organizational commitment. And job satisfaction has a positive and significant impact on organizational commitment. Based on the results of management research Hotel Klapa Resort Pecatu need to create leadership with an exemplary attitude. If the leader has become an exemplary figure for his employees in leading the company, then the employee will follow the exemplary attitude of the leader. Increased leadership attitudes are expected to increase organizational commitment for the achievement of organizational goals.