bluuebunny/crossref_metadata_2025 huggingface dataset:
Особенности обезболивания при снятии зубных отложений у пациентов с болезнями периодонта
Authors: Соломевич А.С. , Даревский В.И. , Егорова К.Ю.
Published: January 2021

Цель исследования. Оценить эффективность применения нестероидного противовоспалительного средства с выраженным анальгезирующим действием для купирования болевого синдрома у пациентов с болезнями периодонта.
Объекты и методы исследования. В клиническом исследовании приняли участие 62 практически здоровых пациента с хроническим генерализованным простым периодонтитом средней степени тяжести и чувствительностью дентина. Всем пациентам проводили профессиональную гигиену ротовой полости. Пациентам основной группы проводили однократную терапию диспергируемыми таблетками ≪Кеторол Инста≫ за 15 минут до проведения профессиональной гигиены ротовой полости, в то время как в контрольной группе обезболивания достигали проведением инфильтрационной анестезии 4% р-ром Артикаина. Для оценки степени выраженности болевых ощущений проводили опрос и использовали вербальную рейтинговую шкалу (NRS), а также комплексный индекс дифференцированной чувствительности зуба КИДЧЗ (Л. Н. Дедова, 2004).
Результаты исследования и их обсуждение. При проведении профессиональной гигиены полости рта препарат ≪Кеторол Инста≫ оказал выраженное лечебное действие, о чем свидетельствовало снижение болевых ощущений у 100% пациентов и ускорение обезболивающего эффекта в среднем на 4 дня.
Заключение. Медикаментозная терапия, основанная на применении нестероидного противовоспалительного средства с выраженным анальгезирующим действием, является безопасной и эффективной, а также может быть рекомендована к применению для снижения уровня болевых ощущений при снятии зубных отложений у пациентов с болезнями периодонта.
Diario de campaña de una división republicana desde el nororiente hasta la costa Caribe colombiana durante las guerras de independencia : transcripción documental.
Authors: Pita Pico Roger
Published: January 2021

La batalla de Boyacá ocurrida el 7 de agosto de 1819 marcó el inicio del proceso de expulsión definitiva de los españoles durante las guerras de Independencia que se extendieron por más de una década en territorio neogranadino. Aunque la región central y nororiental fue liberada de manera vertiginosa y sin mayores confrontaciones, mucho más dispendiosa y prolongada resultó la lucha en la región de la Costa Caribe y en las provincias del Sur. Después de aquella crucial batalla, la estrategia de los altos mandos republicanos a la cabeza del presidente Simón Bolívar y del vicepresidente Francisco de Paula Santander consistió en dos frentes, por un lado, la liberación de las zonas de mayor resistencia realista en la Nueva Granada y, por el otro, el alistamiento de la campaña para liberar a Venezuela. Dentro del primero de estos propósitos, se emprendió una intensa labor de reclutamiento y de organización militar teniendo como base los batallones que habían desarrollado la Campaña Libertadora, integrados por militares neogranadinos y venezolanos, a los cuales se sumaron nuevas partidas de conscriptos alentados con el triunfo en los campos de Boyacá.
Juan Ortiz Escamilla, Calleja Guerra, botín y fortuna, Universidad Veracruzana/El Colegio de Michoacán, México, 2017, ISBN: 978-607- 502-602-2 (UV), ISBN 978-607-9470-93-7 (COLMICH), pp. 271.
Authors: Navarro Méndez José María
Published: January 2021

En el oficio de Clío, la biografía representa uno de los géneros históricos que más fascinan y deslumbran a los lectores. La vida de los individuos normales y excepcionales se convierte en un faro de múltiples experiencias que deslumbran y develan las realidades históricas de los biografiados y como dice François Dosse: “sacar todo a la luz es, por tanto, a la vez la ambición que guía al biógrafo y una aporía que lo condena al fracaso”. Este dilema se le presentó a Juan Ortiz Escamilla en la obra de la que se ocupa esta reseña, se trata de una biografía histórica de Félix María Calleja del Rey, la obra de la autoría de Juan Ortiz Escamilla, coeditada por la Universidad Veracruzana y El Colegio de Michoacán, es un estudio acerca de la vida, los negocios, el botín, así como la fortuna que obtuvo Calleja a lo a largo de su carrera militar en las tierras de la Nueva España en los periodos que van desde la reforma hasta la independencia e incluso más allá.
POTENSI PEMANFAATAN SUMBER DAYA AIR KULONG BEKAS PENAMBANGAN TIMAH UNTUK MENUNJANG IMBANGAN AIR DI KABUPATEN BANGKA TENGAH
Authors: Maini Miskar , Susanti Junita Eka
Published: January 2021

Sumber daya air kulong bekas penambangan timah mempunyai potensi yang cukup besar untuk dimanfaatkan. Pemanfaatan sumber air tersebut belum didasari pada prinsip nilai keandalan kulong itu sendiri. Penelitian ini bertujuan untuk mengetahui berapa besar potensi keandalan kulong dalam pemanfaatnya. Penelitian ini dilakukan pada 7 (tujuh) lokasi kulong bekas penambangan timah dengan karakterikstik luas dan kedalaman kulong yang bervariasi. Karakterikstik luasan dan kedalaman Kulong diukur menggunakan Ecosounder remote sensing. Estimasi aliran yang masuk ke dalam badan kulong diperoleh dengan melakukan analisis ketersedian air menggunakan model NRECA. Simulasi keandalan kulong untuk masa 21 tahun ke depan (2017-2037) dilakukan dengan metode Standard Operating Rule (SOR) dengan memasukan debit sintesis hasil bangkitan data model Markov untuk musim ganda. Hasil penelitian menunjukan potensi ketersediaan debit rerata (Q) untuk Kulong Krasak, Q =7,24 ltr/s dengan keandalan 50% , Kulong Air PL, Q  =11,77 ltr/s dengan keandalan 85%, Kulong Kebintik, Q = 66,45 ltr/s dengan Keandalan 97%, Kulong Baja, Q = 63,02 ltr/s dengan keandalan 0%, Kulong Jongkong Ali, Q = 65,05 ltr/s dengan Keandalan 100%, Kulong Rumbiah, Q = 30,93 ltr/s dengan Keandalan 70%, Kulong Ijo, Q = 37,71 ltr/s dengan Keandalan 96%. Status imbangan air yaitu kebutuhan air total sebesar 297,98 ltr/s, sedangkan ketersediaan air di 7 Kulong dengan total debit sebesar 219,16 ltr/s antara ketersediaan air dari 7 Kulong dengan kebutuhan air dari 6 Kecamatan mengalami defisit air sebesar 78,82 ltr/s, sehingga pemanfaatan 7 Kulong bekas tambang Timah ini cukup sigfinikan untuk menunjang imbangan air di Kabupaten Bangka Tengah.
KAPASITAS LENTUR BALOK KOMPOSIT BETON DENGAN BAJA
Authors: Oktarinata Yuyu , Gunawan Indra , Manalu Donny Fransiskus
Published: January 2021

Penggunaan baja ringan dalam dunia konstruksi sering digunakan sebagai rangka atap pada bangunan. Untuk mengembangkan penggunaan baja ringan dalam dunia konstruksi, maka dilakukan penelitian tentang penggunaan baja ringan sebagai tulangan pada balok beton bertulang. Penelitian ini dilakukan dengan pengujian kuat lentur pada balok beton bertulang dengan mutu beton 17 MPa yang dibebani 2 titik pembebanan. Benda uji terdiri dari 4 variasi; dimana variasi A adalah balok dengan tulangan baja konvensional (rangkap), variasi B adalah balok dengan tulangan baja ringan (rangkap), variasi C adalah balok dengan tulangan baja ringan (tunggal), dan variasi D adalah kombinasi tulangan baja konvensional di daerah tekan dan baja ringan di daerah tarik. Berdasarkan analisis teoritis, nilai momen lentur untuk variasi A = 3,726 kNm, B = 5,460 kNm, C = 5,460 kNm, dan D = 6,780 kNm; nilai lendutan untuk variasi A = 0,791 mm, B = 0,575 mm, C = 0,532 mm, dan D = 0,655mm. Berdasarkan hasil pengujian, nilai kuat lentur untuk variasi A = 16,313 MPa, C = 10,679 MPa, dan D = 13,309 MPa; nilai momen lentur untuk variasi A = 13,199 kNm, B = 9,561 kNm, C = 8,913 kNm, dan D = 11,248 kNm; nilai lendutan untuk variasi A = 2,173 mm, B = 2,420 mm, C = 2,187 mm, dan D = 2,420 mm. Dengan demikian dapat disimpulkan bahwa balok variasi A memiliki nilai kuat lentur dan momen lentur yang lebih besar dengan nilai lendutan yang lebih kecil dibandingkan dengan balok variasi B, C, dan D.
SISTEM INFORMASI ALUMNI SMP N 1 DAYUN MENGGUNAKAN FRAMEWORK LARAVEL DI KAB. SIAK
Authors: Febriani Anita , Linda Wati Wahyu , Fonda Hendry
Published: January 2021

Alumni data is one example of an information system designed to be able to help the work of an agency or company both in processing data to provide complete data through the availability of information services. Similarly, SMP N 1 Dayun which has approximately 5800 alumni and forms a large family bond of alumni which has a vision of realizing the extended family ties of SMP N 1 Dayun as an alumni institution that can accommodate the aspirations of its members and can contribute to the development of the quality of education as school partners. But the alumni data management system that still uses printed documents, resulted in data management that cannot be done effectively and efficiently, and writing errors often occur, it is difficult to find alumni data that has been damaged, and the data is difficult to update because information about alumni can only be accessed through grupchat on social media, whatsapp. With this problem the researcher raised the title of the thesis that is Alumni Information System of SMP N 1 Dayun Using Laravel Framework in Kab. Siak The design of this information system uses usecase diagrams, activity diagrams, class diagrams. Application of the waterfall method as a system development process. Using the programming language Framework Laravel, PHP and MySQL as a database. This information system is expected to help the school and alumni of SMP N 1 Dayun in managing data and as a bridge of hospitality.
MANAJEMEN ABSENSI DI PEMERINTAH KOTA PEKANBARU BERBASIS MVC DAN LARAVEL
Authors: Muhardi Muhardi , Yasriady Dedy , Fonda Hendry
Published: January 2021

Menegakkan disiplin pegawai adalah hal yang mendasar dalam suatu instansi guna meningkatkan produktifitas sumber daya manusianya. Hal ini dapat dimulai dengan menegakkan disiplin kehadiran pegawai, dengan pengontrolan yang tepat, akurat dan cepat. Salah satunya yang dikembangkan disini adalah aplikasi manajemen absensi dalam bentuk web berbasis MVC menggunakan framework Laravel. Pemograman dengan menggunakan metode Model View Controller (MVC. Manajemen absensi ini merupakan aplikasi yang mengolah data log yang dihasilkan oleh perangkat absensi kartu smartcard. Smartcard ini diterbitkan oleh PT. Bank Negara Indonesia Tbk (BNI) bekerja sama dengan Pemko Pekanbaru yang dikenal sebagai kartu SmartMadani. Perangkat absensi dilengkapi dengan kamera untuk mengambil foto saat pegawai mengisi kehadiran. Data kehadiran tersebut kemudian diolah untuk dijadikan sebagai laporan kehadiran bulanan. Aplikasi ini membuat rekapitulasi kehadiran pegawai bulanan, terlambat, jumlah cuti serta melakukan penghitungan persentase Tunjangan Kinerja (Tukin) sesuai dengan Peraturan Walikota yang berlaku..
SISTEM E-KARYAWAN SEKOLAH TINGGI MANAJEMEN INFORMATIKA DAN KOMPUTER (STMIK) HANG TUAH PEKANBARU BERBASIS WEB
Authors: Hartomi Zupri Henra
Published: January 2021

Sistem E-karyawan Sekolah Tinggi Manajemen Informatika dan Komputer (STMIK) Hang Tuah Pekanbaru, telah terkomputerisasi dan terhubung dengan jaringan internet atau Web, namun masih terbatas pada pengelolaan data master karyawan dan data master user, dengan demikian sulit untuk bagian kepegawaian melakukan pengelolaan data pegawai karena belum lengkapnya modul layanan yang terdapat pada sistem E-karyawan Sekolah Tinggi Manajemen Informatika dan Komputer (STMIK) Hang Tuah Pekanbaru tersebut. Selain itu masih adanya cara pendokumentasian data pegawai secara konvensional yang menyulitkan petugas kepegawaian dalam mendapatkan informasi pegawai. Maka dari itu peneliti mencoba mengembangkan sistem E-karyawan Sekolah Tinggi Manajemen Informatika dan Komputer (STMIK) Hang Tuah Pekanbaru dengan cara penambahan beberapa modul layanan agar informasi yang dihasilkan lebih bersifat informatif seperti penambahan modul-modul master, modul-modul manajemen pegawai dan modul-modul laporan pegawai. Pengembangan sistem E-karyawan ini menggunakan metode Model Waterfall, digambarkan pada bahasa pemodelan UML (Unified Modelling Language), dirancang menggunakan bahasa pemrograman PHP (Personal Home Page) dan database server menggunakan MySQL (My Structured Query Language). Dengan adanya pengembangan sistem E-karyawan ini maka akan membantu bagian kepegawaian dalam mengelola kegiatan administrasi kepegawaian seperti pengolahan data pegawai, riwayat jabatan, riwayat pendidikan, riwayat kepanitiaan, riwayat penugasan,  riwayat pelatihan, riwayat sosialisasi, riwayat kunjungan kerja, mencetak Surat Perintah Tugas (SPT), mencetak Surat Perintah Perjalanan Dinas (SPPD) dan mencetak surat biaya perjalanan dinas pegawai sehingga bagian kepegawaian dapat memeperoleh data pegawai dengan cepat dan akurat serta mempermudah dalam pembuatan laporan kepegawaian Sekolah Tinggi Manajemen Informatika dan Komputer (STMIK)  Hang Tuah Pekanbaru.
RANCANG BANGUN KRAN WUDHU OTOMATIS DAN PENGISIAN TANK AIR OTOMATIS PADA STMIK HANG TUAH PEKANBARU BERBASIS ARDUINO UNO
Authors: Wahyuni Refni , Wiyono Ismail , Fonda Hendry
Published: January 2021

Penghematan sumber daya alam merupakan suatu yang sangat diperlukan saat ini, baik di lingkungan rumah tangga maupun di lingkungan yang lebih luas. Penggunaan  tangki air yang digunakan untuk menampung air dapat mengurangi penggunaan energi listrik dan menyediakan pasokan air secara berkelanjutan. Penggunaan kran otomatis juga punya andil yang cukup besar dalam penghematan air ketika tingkat kepedulian seseorang kurang baik. Pada penggunaan kran wudhu konvensional ini pengguna tidak bisa mengontrol penggunaan air sehingga banyak permasalahan yang terjadi seperti pemborosan air jika penggunanya lalai dalam menutup kran, yang berakibat air akan keluar secara terus menerus. Selain itu pengisian tangki air juga menjadi faktor penting dalam penghematan air, cadangan air pada tangki harus terkontrol dengan baik agar tetap terjaga ketersediaanya. Berdasarkan permasalahan yang ada maka dibuatlah sebuah alat kran wudhu otomatis dan pengisian tank air otomatis berbasis Mikrokontroler arduino uno dengan dukungan metode prototype yang bisa membantu efisiensi dalam pembuatan karena peneliti mendengarkan langsung kebutuhan dari pengguna. Selanjutnya mikrokontroler dibantu  beberapa sensor, dimana setiap sensor memiliki tugas yang berbeda.pada pengisian tank air otomatis, Sensor Ping berfungsi sebagai pengukur jarak antara posisi air dengan sensor dimana ketika kapasitas air sedikit maka mesin pompa air akan menyala dan apabila kapasitas air sudah penuh maka mesin pompa air akan mati. Pada kran air otomatis, sensor infrared berfungsi sebagai pendeteksi objek tangan atau kaki manusia, apabila ada terdeteksi maka air akan keluar melalui keran air dan apabila tidak ada terdeteksi lagi maka keran otomatis tertutup. Dalam penelitian ini diteliti bagaimana efektifitas sensor infrared dalam mendeteksi keberadaan objek dan sensor ping dalam mendeteksi kapasitas air dalam tank. Semoga dengan adanya alat ini pengguna yang akan melakukan wudhu menjadi lebih mudah dan ketersediaan air selalu terjaga.
SISTEM INFORMASI PENGELOLAAN DATA PERKARA PADA POSYANKUM PENGADILAN NEGERI PEKANBARU BERBASIS WEB
Authors: ST,.M.Kom Mardeni
Published: January 2021

Bantuan hukum merupakan instrumen penting dalam Sistem Peradilan Pidana karena merupakan bagian dari perlindungan Hak Asasi Manusia (HAM) bagi setiap individu, termasuk hak atas bantuan hukum. Jaminan terhadap hak dan kewajiban ini ditegaskan dan dijadikan landasan bagi pembentukan Undang- Undang Nomor 16 Tahun 2011 tentang bantuan hukum. Posyankum (Pos Pelayanan Hukum) Pengadilan Negeri Pekanbaru merupakan salah satu perwujudan dari pemberian bantuan hukum yang disediakan untuk memberikan perlindungan hukum bagi masyarakat kurang mampu di wilayah Pengadilan Negeri. Karena tergolong baru, informasi adanya Posyankum di Pengadilan Negeri Pekanbaru belum tersebar luas kepada masyarakat. Oleh karena itu dengan adanya system informasi berbasis web pengelolaan data perkara pada Posyankum Pengadilan Negeri Pekanbaru dapat memberikan informasi dan mempenmudah staff dalam melakukan proses pengelolaan data perkara yang sangat menunjang bagi proses pembuatan laporan perkara, serta status update laporan yang masuk dan telah diputus dalam proses persidangan di Posyankum Pengadilan Negeri Pekenabaru.
IMPLEMENTASI TEXT MINING PADA TWITTER DENGAN ALGORITMA K-MEANS CLUSTERING SEBAGAI DASAR KEBIJAKAN MARKETING BIRO PERJALANAN WISATA
Authors: Fonda Hendry fonda , Mustika Budy , Sabna Eka , Irawan Yuda
Published: January 2021

Pada zaman modern seperti saat ini, penggunaan internet dan sosial media adalah instrumen yang wajib dalam menjalani kehidupan sehari-hari. Salah satunya twitter. Setiap unggahan pengguna twitter tersimpan pada media penyimpanan milik pengembangnya dan jarang dimanfaatkan dengan baik. Setiap pelaku usaha membutuhkan informasi tentang apa yang sedang tren terkait dengan jenis produk usahanya. Untuk itulah penulis ingin menggali dan mengelompokkan data bagi sosial tersebut untuk mendapatkan sebuah informasi yang kiranya bermanfaat untuk pelaku usaha. Dalam penelitian ini, penulis menggunakan metode pendekatan deskriptif analitis. Metode ini mendeskripsikan atau memberi gambaran terhadap objek yang diteliti melalui data atau sampel yang telah terkumpul sebagaimana adanya tanpa melakukan analisis dan membuat kesimpulan yang berlaku untuk umum. Dalam hal pengumpulan data dimulai dengan mengunduh data unggahan para pengguna twitter dan kemudian diolah dengan algoritma K-Means. Hasil yang diperoleh dari pengelompokan data tersebut menghasilkan data berupa kata-kata yang sedang tren dibicarakan. Hasil inilah yang digunakan oleh pelaku usaha untuk menentukan arah kebijakan pemasaran produknya. Hasil tersebut juga bisa dimanfaatkan oleh pelaku usaha sebagai bahan prediksi terhadap kecenderungan masyarakat dalam berwisata.
PENERAPAN DATA MINING UNTUK PENGELOMPOKAN DATA REKAM MEDIS PASIEN BERDASARKAN JENIS PENYAKIT DENGAN ALGORITMA CLUSTERING (Studi Kasus : Poli Klinik PT.Inecda)
Authors: Ordila Rian , Wahyuni Refni , Irawan Yuda , Yulia Sari Maulita
Published: January 2021

Data Mining adalah suatu metode pengolahan data untuk menemukan pola yang tersembunyi dari data tersebut. Rekam Medis adalah berkas yang berisikan catatan dan dokumen tentang identitas pasien, pemeriksaan, pengobatan, tindakan, pelayanan lain yang telah diberikan kepada pasien. Poli klinik PT.Inecda menerima pasien sebanyak 20 pasien s/d 40 pasien dalam satu hari, dalam satu bulan bisa mencapai 600 pasien s/d 750 pasien, sedangkan dalam satu tahun Poli klinik PT.Inecda bisa menerima pasien kurang lebih sekitar 8.400 pasien dalam satu tahun.  K-Means Clustering adalah suatu metode penganalisaan data atau metode Data Mining yang melakukan proses pemodelan tanpa supervisi (unsupervised) dan merupakan salah satu metode yang melakukan pengelompokan data dengan sistem partisi. Hasilnya adalah melakukan pengelompokan dengan menggunakan K-Means Clustering dan RapidMiner yang dapat membantu melakukan pengelompokan berdasarkan wilayah, jenis penyakit dan Umur.
PENERAPAN TEXT MINING UNTUK PENGELOMPOKAN PENELITIAN DOSEN
Authors: Sabna Eka
Published: January 2021

Penelitian merupakan salah satu dari Tri Darma Perguruan Tinggi. Setiap Dosen wajib melakukan penelitian.  Hasil penelitian Dosen di Program Studi semakin bertambah dan beragam. Penelitian ini dilaksanakan untuk mengelompokkan judul-judul dari penelitian Dosen dengan menggunakan Text Mining. Pengelompokkan ini bertujuan untuk mengetahui Topik-topik penelitian Dosen. Dari hasil ini dapat membantu Program Studi dan Peneliti-peneliti yang lain untuk melihat kecendrungan (trend) penelitian yang dilakukan Dosen. Selain itu Program Studi dapat menggunakan hasil penelitian ini untuk menentukan Dosen Pembimbing dan Penguji dari mahasiswa yang mengambil matakuliah Skripsi. Selain itu hasil penelitian ini juga dapat membantu Dosen dalam mencari relasi/rekanan dalam penelitian Dosen tersebut selanjutnya.
Pancreatic steatosis: a giant step forward or recognition of ignorance
Authors: Gubergrits N. B. , Byelyayeva N. V. , Mozhyna T. L. , Monogarova N. E. , Borodiy K. N. , Yuryeva A. V.
Published: January 2021

This review analyzes the terminology of pancreatic steatosis, the data about the prevalence of non-alcoholic fatty pancreas disease (NAFPD) were given.

The etiological factors of NAFPD are usually subdivided into hereditary, metabolic, and toxic ones. The main etiopathogenetic factor of pancreatic fatty infiltration is obesity: it causes pancreatic infiltration by adipocytes, leading to the development of NAFPD. The pathogenesis of the disease is associated with adipocytic tissue dysfunction, which induces local and systemic inflammatory response with corresponding clinical consequences. Insulin resistance and oxidative stress play major role in the pathogenesis of NAFPD. From a histological point of view, NAFPD is a heterogeneous process, characterized by excessive intracellular accumulation of lipids and fatty infiltration followed by fatty replacement of the pancreas.

NAFPD clinical picture is asymptomatic and nonspecific. Diagnosis of NAFPD is based primarily on the results of imaging methods (ultrasound, CT, MRI). A consequence of NAFPD is exocrine pancreatic insufficiency requiring enzyme replacement therapy. One of the NAFPD complications is the development of pancreatic adenocarcinoma.

Currently, standards for the diagnosis, treatment and management of patients with NAFPD have not been developed yet, but on used the guidelines for the treatment of non-alcoholic fatty liver disease (rational diet, exercises, weight loss). The “gold standard” of enzyme replacement therapy, such as Creon®, is used for correction of exocrine pancreatic insufficiency. The detailed analysis of the clinical case of total pancreatic steatosis with severe exocrine pancreatic insufficiency was done in this article.
Bile acids, non-alcoholic fatty liver and pancreatic disease: chained by ursodeoxycholic acid?
Authors: Gubergrits N. B. , Byelyayeva N. V. , Mozhyna T. L.
Published: January 2021

Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic fatty pancreatic disease (NAFPD) develop against the background of metabolic syndrome, systemic insulin resistance, oxidative stress, changes in lipid and carbohydrate metabolism. There are a number of similarities between NAFLD and NAFPD: the natural course of diseases proceeds from steatosis through inflammation to fibrosis and cancer, one of the etiopathogenetic factors is the disbalance of bile acids synthesis and low expression of farnesoid receptor X (FXR). One of the possible methods of treatment NAFLD and NAFPD is a correction of the biosynthesis of bile acids and increase FXR expression with FXR agonists. Ursodeoxycholic acid (UDCA) is a selective FXR agonist. It has a multipled spectrum of actions: anticholestatic, anti-apoptic, antioxidant, cytoprotective, antifibrotic, hypocholesterolemic, immunomodulatory, hepatoprotective. The ability of UDCA correct lipid and carbohydrate metabolism in combination with anti-inflammatory and antiapoptic effects may be of great importance for the treatment of NAFLD and NAFPD. The article reviews the results of clinical and experimental studies describing the efficacy of UDCA in NAFLD and some pancreatic diseases. It has been suggested that the therapy of UDCA can reduce the severity of NAFLD and NAFPDand improve the functional activity of hepatocytes and β cells. The need for randomized clinical trials was emphasized in order to make an informed decision on the expediency of including UDCA in the treatment of NAFLD and NAFPD.
Duodenum-preserving pancreatic head resections for surgical treatment of paraduodenal pancreatitis
Authors: Usenko O. Yu. , Kopchak V. M. , Khomiak I. V. , Khomiak A. I. , Malik A. V.
Published: January 2021

Introduction. Up to date, no consensus exists on the surgical treatment of paraduodenal pancreatitis (PDP). Most authors prefer to perform pancreaticoduodenectomy when surgical treatment is indicated. However, such an aggressive approach may not always be justified for the treatment of benign disease. The aim of our study was to investigate the results of duodenum-preserving pancreatic head resections (DPPHR) for the treatment of PDP.

Materials and methods. We performed a retrospective analysis of a database consisting of 112 patients with PDP treated in Shalimov National Institute of Surgery and Transplantology from 2014 to 2019. A total of 45 patients after DPPHR were included to the study. Such modifications of DPPHR as Frey’s, Beger’s and Berne’s procedures were used. The primary study endpoint was pain control assessed according to the Izbicki pain score before surgery and at follow-up visits. Secondary endpoints were defined as complication rate (Clavien — Dindo >2), hospital length of stay and 90-day mortality. All patients were followed-up for the assessment of pain cessation with a median of 33 months (range 8–54 months).

Results. There were 42 males (93.3%) and 3 females (6.7%) in the study group. Preoperative Izbicki pain score result was 52.6 points. Follow-up pain score results were significantly lower at 11.7 points. Postoperative complication rate (Clavien — Dindo >2) was measured at 8.9%. Median hospital length of stay was 17.4 days. No mortality was recorded in the study group. All results were statistically significant (p<0.05).

Conclusion. Application of DPPHR for the surgical treatment of PDP allows to achieve excellent results in terms of pain control (52.6 and 11.7 points on the Izbicki pain score before surgical intervention and at follow-up), while maintaining low complication (8.9%) and mortality (0%) rates.
Bacterial overgrowth syndrome of upper parts of gastrointestinal tract in acute necrotizing pancreatitis
Authors: Rotar O. V. , Khomiak I. V. , Polioviy V. P. , Rotar V. I.
Published: January 2021

Aim: to study the changes in the microflora of the upper part of digestive tract during acute necrotizing pancreatitis.

Material and methods. Acute necrotizing pancreatitis was induced in 42 white rats; changes in the mucous microflora of the upper part of digestive tract were studied. Bacteriological examination of the contents of the proximal small intestine was performed in 42 patients with acute necrotic pancreatitis during gastrofibroscopy.

Results and discussion. Induction of acute necrotic pancreatitis was accompanied by impaired colonization resistance of the intestinal mucosa due to the elimination of bifidobacteria and lactobacilli: the frequency of their growth from the mucosa decreased threefold (p<0.01), and the population level, respectively, by 25% (p<0.05) and by 36% (p<0.02). The mucosa was actively colonized by gram-negative pathogenic and conditionally pathogenic enterobacteria at high population level (3.07‒5.39 lg CFU/g), which allowed this microflora to overcome the damaged intestinal barrier and translocate. Pathogenic Escherichia spp. and Proteus spp. were cultivated from the mesenteric lymph nodes in 24 hours; Enterobacteria spp. and Staphylococci spp. were isolated from portal blood, pancreatic tissue, and peritoneal cavity 48 hours after induction of acute pancreatitis. Eight strains of gram-negative microorganisms were identified in small intestine in 69% of patients before surgery. Similar microflora was cultivated from pathological foci in 57.4% of patients after surgery.

Conclusion. Severe deficiency of autochthonous anaerobic microflora occurred in the upper parts of the digestive tract in acute necrotizing pancreatitis, causing excessive colonization by pathogenic and conditionally pathogenic microorganisms and promoting bacterial translocation.
Chronic pancreatitis: what should be considered in diagnosis, treatment, and prognosis
Authors: Khristich T. N.
Published: January 2021

The aim of the literature review is to draw attention of doctors to the need of considering not only well-known etiological factors, but also pathogenetic ones that have an impact on the progression, chronicity of the process, treatment, prevention, and prognosis.

The role of alcohol, mechanism of obstruction of the pancreatic ducts in the occurrence of abdominal pain in chronic pancreatitis, and the development and progression of exocrine pancreatic insufficiency are discussed in detail.The issues of the onset of chronic pancreatitis in elder age, comorbidity with other diseases of the internal organs, with a lack of certain vitamins are considered. It is necessary to remember that exocrine insufficiency can be associated with the progression of glandular fibrosis, metabolic disorders, food intolerance, allergic syndrome, which provoke acute attacks.The author draws attention to the fact that the syndrome of inflammatory, enzymatic intoxication and the syndrome of disseminated intravascular coagulation should not be missed out in the acute nature of the process. Above-listed recommendations will help to correctly evaluate the clinical picture and prescribe the proper treatment, as well as to prevent the development of complicationsin time.
Klotho protein as a mediator of antioxidant defense in young people with gastroesophageal reflux disease and autoimmune thyroiditis
Authors: Pasiieshvili T. M.
Published: January 2021

Aim: to establish the content and role of Klotho protein in the pathogenesis of gastroesophageal reflux disease, which occurs against the background of autoimmune inflammation in young people.

Materials and methods. Three groups of patients were involved in the study: with the gastroesophageal reflux disease (GERD ) and autoimmune thyroiditis (AIT ) (120 persons), isolated GERD (45) and AIT (42) aged 18 to 25 years, of the same sex and duration of the disease. The content of Klotho protein was determined in the serum by ELISA, Elabscience reagents (ELISA, USA).

Results. Significant increase in Klotho protein was detected in patients with GERD and especially in its combination with AIT relative to the control. Content of Klotho protein did not correlate with the morphological form of the disease and its duration. In patients with isolated AIT , Klotho protein level did not have a significant difference with control group.

Conclusion. The GERD and its combination with AIT in young people are accompanied by an increase in Klotho protein content, as a result of the presence of an active inflammatory process in the esophagus mucosa and its stimulating effect on antioxidant defense processes.
ДО ПИТАННЯ ЩОДО ПСИХОЛОГО-ПЕДАГОГІЧНОЇ КОМПЕТЕНТНОСТІ МАЙБУТНІХ ПЕДАГОГІВ ДОШКІЛЬНОЇ ОСВІТИ В СУЧАСНИХ УМОВАХ
Authors: Теличко Т. В.
Published: January 2021

Стаття присвячена формуванню необхідних умінь і навичок грамотного вирішення педагогічних конфліктів та загальної психолого-педагогічної компетентності педагогів-вихователів. Визначено та охарактеризовано зміст, особливості та структуру психолого-педагогічної компетентності. Доведено, що психолого-педагогічна компетентність є однією з визначальних у структурі педагогічної діяльності сучасних педагогів закладів дошкільної освіти та складовою їхньої професійної компетентності. Практика показує, що необхідно розширити психолого-педагогічну підготовку вихователів закладів дошкільної освіти. Молодий педагог повинен уміти творчо співпрацювати з дітьми, батьками і з колегами; грамотно вирішувати конфліктні ситуації. А для цього необхідно засвоїти певний рівень теоретичних знань і практичних навичок поведінки в конфліктних ситуаціях, розробити необхідні рекомендації щодо попередження та вирішення конфліктних ситуацій для формування сприятливого морально-психологічного клімату.

Психолого-педагогічна компетентність передбачає узгодженість між психологічними, педагогічними та методичними знаннями, практичними вміннями і реальною поведінкою, яку педагог демонструє в процесі педагогічної взаємодії. Встановлено, що майбутні вихователі закладів дошкільної освіти часто переживають низку труднощів, пов’язаних із застосуванням досягнень психології у професійній практичній діяльності. Зазначено, що у відборі змісту матеріалу, що викладається, необхідно враховувати його наукову і практичну зорієнтованість. Це дає студентам розуміння практичної цінності психологічних знань та можливостей їхнього використання.
ОСОБЛИВОСТІ ЗАСТОСУВАННЯ МУЛЬТИМЕДІЙНИХ ЗАСОБІВ НА ЗАНЯТТЯХ З ІНОЗЕМНОЇ МОВИ
Authors: Дячок Н. В.
Published: January 2021

У статті репрезентовано роль використання мультимедійних засобів на заняттях з іноземної мови. Метою статті є обґрунтувати доцільність застосування мультимедійних засобів на заняттях з іноземної мови у закладах вищої освіти. Використання мультимедійних засобів у викладанні іноземної мови надає можливість знаходити нові підходи до розробки навчальних матеріалів. Методологія дослідження передбачає аналіз застосування мультимедійних засобів на заняттях з іноземної мови через основні наукові підходи, такі як: компетентнісний, міждисциплінарний, комунікативно-діяльнісний і особистісно-зорієнтований. Розглянуто особливості застосування мультимедійних засобів на заняттях іноземної мови: збагачення змісту освітнього процесу і підвищення мотивації до вивчення іноземної мови; становлення студента суб’єктом комунікативного спілкування з викладачем. Доведено, що особливості досліджуваного явища забезпечують гнучкість та інтеграцію різних типів мультимедійної навчальної інформації. Виокремлено систему мультимедійних засобів для ефективного оволодіння іноземною мовою, яка складається з чотирьох компонентів, таких як: автоматизовані освітні системи, експертні освітні системи; навчальні бази даних та навчальні бази знань; освітні комп’ютерні і телекомунікаційні мережі. Зроблено висновок про те, що використання мультимедійних засобів на заняттях з іноземної мови розширює і урізноманітнює освітній процес із вивчення іноземних мов. Мультимедійні засоби на заняттях з іноземної мови дозволяють збільшити швидкість сприймання, розуміння та глибину засвоєння величезних масивів знань. Використання мультимедійних засобів на заняттях з іноземної мови дозволяють створити ефективний допоміжний технічний наочно-слуховий засіб навчально-пізнавальної діяльності студентів; підвищити мотивацію і бажання студентів вивчати іноземну мову більш інтенсивно.
Parâmetros de indenização dos danos morais no Direito do Trabalho
Authors: De Azevedo Lopes Othon
Published: January 2021

O presente artigo tem como objetivo analisar os parâmetros para quantificação das condenações por danos morais introduzidos pela Reforma Trabalhista (Lei nº 13.467/2017) e busca avaliar se estes parâmetros contribuem para a proteção simbólica da personalidade. O artigo se inicia com uma reconstrução histórica do instituto do dano moral e apresenta discussão sobre seu legado para nossa sociedade e para o Direito Privado. Em seguida, a reflexão situa os danos morais dentro do marco da proteção à dignidade humana e apresenta seus desdobramentos para os direitos da personalidade. Posteriormente, apresenta-se discussão jurídica sobre o instituto do dano moral individual e o papel das sanções de natureza civil, introduzidas historicamente pelo Direito Moderno, na proteção dos direitos da personalidade. Por fim, à luz das reflexões teóricas sobre o dano moral, o artigo avalia as inovações trazidas pela Reforma Trabalhista quanto aos parâmetros de quantificação dos danos morais e se tais inovações permitem interpretação conforme da legislação vigente sobre dano moral.
 
PALAVRAS-CHAVE: Dano moral. Direitos da Personalidade. Reforma Trabalhista. Critérios para fixação. Função preventiva fiduciária.
Mútuo consentimento
Authors: Coutinho Aldacy Rachid
Published: January 2021

O presente artigo objetivo analisar criticamente a reforma trabalhista introduzida pela Lei 13.467, de 2017, pela introdução da possibilidade de distrato como forma de extinção do contrato de trabalho por acordo bilateral. O mútuo consentimento abre novas fronteiras no direito do trabalho para discussão sobre a possibilidade ou não de migração, pela transposição, de conceitos de direito civil, ultrapassados ou atuais, que se referem ao contrato e aos princípios da liberdade e autonomia da vontade ou privada. A delimitação das suas consequências no distrato acarreta o necessário controle do ato jurídico pela validade da manifestação do consentimento, com a observância da incidência de preceitos constitucionais que devem ser observados e a limitação decorrente da autonomia privada que não permite às partes contratantes a livre disposição dos efeitos decorrentes da emissão de vontade.
 
PALAVRAS-CHAVE: Direito do trabalho. Extinção do contrato. Distrato.
A aposta nos escombros: reforma trabalhista e previdenciária - a dupla face de um mesmo projeto
Authors: Antunes Ricardo , Praun Luci
Published: January 2021

RESUMO
Este artigo tem como centro de suas reflexões a reforma trabalhista brasileira e suas repercussões no mundo do trabalho. É parte de seus objetivos apresentar elementos que permitam pensá-la como projeto articulado, em diferentes níveis, a uma outra reforma, em trâmite no Congresso Nacional, a da previdência. Busca, nesse contexto, contribuir para a projeção de alternativas e formas de resistência ao que denominamos como aposta nos escombros.
Palavras-chave: Direitos sociais e do trabalho; reforma trabalhista e previdenciária, neoliberalismo.
Comparative evaluation of whole grains flour chemical composition of grain sorghum (Sorghum bicolor) and chia (Salvia hispanica)
Authors: Tretiakova S. , Voitovska V. , Yevchuk Y. , Kononenko L.
Published: January 2021

The article highlights a complex of studies and a comparative assessment of flour of various varieties and hybrids of chia and sorghum. It was found that, in terms of their chemical composition, these crops are advisable to use as raw materials for the production of gluten free products. To live a full life, people with celiac disease must constantly consume gluten-free foods. Rice, buckwheat, millet, corn are considered safe, and amaranth, quinoa, sago, Setaria italica, sorghum are also less common in Ukraine. To obtain high-quality gluten-free products, it is important to choose the right raw materials and their ratio in chemical composition. Therefore, it is advisable to study and compare the chemical composition of sorghum and chia flour. The aim of the research was to study and compare the chemical composition of whole grain sorghum flour versus chia for use in the food industry as a source of gluten-free nutrition. The experimental part of the work was carried out during 2017–2019 in the hybrids of grain sorghum of Ukrainian (Lan 59), French (Targga) and American (Prime) selection and Spanish sage (chia) (Salvia hispanica) varieties: Salba, Tzotzol, Iztac. Whole grain sorghum and chia flours were obtained from their grains and various chemical constituents were determined. Comparative analysis of the chemical composition of sorghum and chia flour allows us to note that, on average, the protein content in sorghum was in the range from 9.53 to 10.6 g, in chia varieties from 14.98 to 16.52 g, which is on average five, 8 g more. The data on the determination of fats show that in the hybrid of sorghum of Ukrainian selection, this indicator was 2.8 g, French 1.24 g, and American – 3.3 g, as for chia, this indicator is much higher and varies by varieties from 30, 12 to 30.71 g. Starch is the main component of flour and in sorghum; its mass fraction is more in the Prime hybrid 63.7 g, Lan 59 – 63.1 g and the smallest amount in Targga – 62.7 g. It has been determined that grain sorghum and chia flour has a high content of B vitamins, which act as coenzymes of a number of metabolic processes. In addition to the vitamins listed above, sorghum flour contains vitamins B9, B5, B6 as well. Chia varieties have high levels of micro- and microelements.
Key words: flour, vitamins, microelements, proteins, fats, carbohydrates, celiac disease, sorghum, chia.
Assessment of cherry fruits quality under preprocessing with polyccharidic compositions during storage by the Harrington method
Authors: Vasylyshyna O.
Published: January 2021

Cherry fruits have a short harvesting season and a limited shelf life of only a few days. Therefore, it is necessary to develop modern storage technologies that would allow to extend their consumption period. The purpose of the study was to determine the storage efficiency of cherry fruits, pre-treated with polysaccharide compositions, by the Harrington method. For research, the fruits of Alpha and Pamyat Artemenka cherries varieties, sprayed with a solution of salicylic acid; solution of chitosan with salicylic acid, dried, removed from the trees at the consumer stage of maturity, each variety and type of processing, put in boxes №5 for storage at a temperature of 1±0.5 °C and relative humidity of 95±1 %. Physicochemical and organoleptic parameters were determined in the fruits during storage. The generalized Harrington function was used to summarize the results of the research. According to the generalized response, cherry fruits of the Alpha and Pamyat Artemenka varieties are better preserved after pre-treatment with a solution of salicylic acid with chitosan (D = 0.95 and 0.97). They were slightly inferior to cherry fruits treated with a solution of salicylic acid with a generalized response rate of 0.86 and 0.77. Cherry fruits pre-treated with a solution of salicylic acid with chitosan were stored for up to 30 days whereas the untreated ones (control) were stored for only 15 days (D = 0.63 and 0.49). Since the indicators of the generalized response were higher in the fruits of Alpha cherries, compared with the Pamyat Artemenka, Alpha cherry fruits can be considered more suitable for storage. Thus, the use of the generalized Harrington desirability function made it possible to objectively assess the cherries for suitability for storage. Treatment with a solution of salicylic acid with chitosan was the best for processing cherry fruits before storage.
Key words: cherry fruits, Harrington method, salicylic acid, chitosan, storage.
Inheritance in F1 and transgressive variability in F2 of the main ear length by crossing wheat varieties with different maturity
Authors: Lozinskiy M. , Ustinova H.
Published: January 2021

In 2017–2019, the nature of the inheritance of ear length in F1 and transgressive variability in F2 populations obtained by hybridization of soft winter wheat varieties with different maturity were studied. It was found that in most combinations of crossbreeding, inheritance of ear length had a positive overdominance (hp = 1.1–39.0). A positive hypothetical heterosis was determined in early-maturing varieties in the maternal form, with the exception of the Kolchuga / Chornyava combination, by the length of the main ear (Ht = 3.6–44.8 %). a positive true heterosis (Hbt=1,1–32.9 %) was found in 15 of 20 hybrids. During the hybridization of medium-early, medium-ripe and medium-late varieties, all hybrids showed a positive hypothetical heterosis and 19 of 22 combinations had positive true heterosis. A significant influence of hybridization components on the indicators of the phenotypic dominance degree, hypothetical and true heterosis was established. Most of the F2 populations significantly exceeded the parental components of hybridization by the extreme maximum indexes of the main ear length, which indicates a significant shaping process and the possibility of selection on the basis of the studied trait. The maximum length of the main ear (10.3–12.1) was formed by most populations in which the maternal forms were varieties Kolchuga and Chornyava, as well as combinations Zolotokolos / Chornyava, Zolotokolosa / Stolychna and Yednist / Vidrada. The extreme maximum values reached 13.0–15.0 cm. In 36 of the 42 F2 populations, a positive degree and frequency of transgressions by the length of the main ear were determined, and their indexes largely depended on the pairs selection for hybridization. The highest degree of positive transgression was observed in the population Yednist / Vidrada (44.4 %) with a recombinant frequency of 86.7 %. Populations were characterized by a high degree and frequency of positive transgressions: Kolchuga / Yednist; Myronivska early / Antonivka; Myronivska early / Vdala; Zolotokolosa / Vidrada; Dobirna / Pyvna; Zolotokolosa / Stolychna; Zolotokolosa / Shchedra nyva; Myronivska early / Yednist; Myronivska early / Zolotokolosa; Myronivska early / B.Ts. n / a. Key words: soft winter wheat, maturity of varieties, combinations of crossbreeding, inheritance, hybrids, ear length, hypothetical and true heterosis, degree of phenotypic dominance, F2 populations, degree and frequency of transgressions.
Determination of antibiotic residues in Black tiger shrimps (Penaeus monodon) and commercial shrimp feeds in Chattogram
Authors: Mahmood Sharjil , Sultana Nusrat , Mahmud Abdullah Al , Akter Sharmin , Kabir Md Hossain , Saha Suvanker
Published: January 2021

Shrimps are good source of protein and also good exportable item for its quality all over the world. Inappropriate use of antibiotics in the production of local and export quality shrimps can facilitate infiltration of antibiotic residues into human bodies which are toxic enough to cause serious health hazard. The present study was investigated to determine the antibiotic residues in some selected local market and export quality shrimps and also commercial shrimp feeds in chattogram. Local grade and export grade samples of Black tiger shrimps (Penaeus monodon) and feeds of four different companies were taken for the completion of this study. The permissible residual limit for the shrimp samples were- 0.3(μg/kg) for Chloramphenicol and 1.0 (μg/kg) for AHD, AMOZ, SEM, AOZ. Black tiger shrimps from local market 1 had high concentration of Chloramphenicol (0.35 μg/kg) and SEM (1.2 μg/kg) residues whereas Market 2 showed maximum residues in AMOZ (1.2 μg/kg) and SEM (1.1 μg/kg). Whereas, Market 3 showed negative result. Local market 4 had high concentration of Chloramphenicol (0.4 μg/kg) and AOZ (1.2 μg/kg) residues. However, in export grade shrimps antibiotic residues was found under the maximum residual limit in all samples. Also, among four feed tested, two of them were found positive for chlorampenicol and nitrofurans. The result was considered significant where P>0.05. So, legal actions should be taken against the farmers and the farms that overuse antibiotics in shrimps. Also, people should be made aware of the harmful effects of antibiotics so that the impact can be minimized.

Asian J. Med. Biol. Res. December 2020, 6(4): 623-627
Effects of dietary polyunsaturated fatty acid on reproduction and developmental biology of Gangetic Mystus (Mystus cavasius) (Hamilton-Buchanan, 1822)
Authors: Akter Rafia , Ema Noore Safa , Hossain Md Saddam , Hossain Zakir
Published: January 2021

The present study was undertaken to determine the effects of polyunsaturated fatty acids (PUFAs) on enhanced maturation, spawning, embryonic and larval development of endangered Gangetic Mystus (Mystus cavasius). Fishes were collected from the Brahmaputra River, Mymensingh, Bangladesh and stocked in the cisterns. Treated group was provided supplemental diet enriched with 1% squid extracted lipids as a source of PUFAs four months whereas controlled group fed the same diet except PUFAs. In comparison with the control group, treated group exhibited higher reproductive performances in spawning trial. The fertilization rate (79.5±1.49), hatching rate (72.29±1.78) and survival rate (64.31±0.48) of offspring were significantly higher in treated group compared to control. Consequently, early embryonic and larval development was observed in the treated fishes. Therefore, the present study indicates the enhanced reproductive and developmental performances of (Mystus cavasius) owing to PUFAs supplementation in diet.

Asian J. Med. Biol. Res. December 2020, 6(4): 641-649