bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of the use of deep brain stimulation in the treatment of Parkinson's disease
Authors: Fonseca Júnior Dinarthe Dantas da , Oliveira Júnior Adenilson Raimundo de , Silva Beatriz Gonçalves Ligeiro da , Maia Maria Cecília Gomes , Lima Gabriela Goveia de Sousa Castilho de , Wagner Ana Carolina Barambo , Coqueiro Renata de Andrade , Broch Luise Regina , Sola Juliana Silveira , Vasconcellos Marcos Augusto Bustamante de , Gomes Juliana Yoshie Hara , Coriolano Thays Dayane Oliveira Araújo , Leal Wolney Barros , Lima Thaíse Ferreira Carneiro de , Santos Marcos de Paula Oliveira
Published: July 2024

The central question of this study was the Analysis of deep brain stimulation (DBS) in the treatment of Parkinson's disease. The need to more deeply understand the benefits and limitations of DBS, especially given its increasing use as the standard treatment for advanced Parkinson's patients, justified this research. Detailed analysis of clinical outcomes and improvements in quality of life provided by DBS could offer valuable information for optimizing treatment protocols and clinical decision-making. This study aimed to address these issues through a comprehensive review of the existing literature, analysis of clinical data, and evaluation of best practices for DBS implementation in Parkinson's disease treatment. The methodology consisted of a qualitative literature review, utilizing sources such as Scielo, Google Scholar, scientific journals, and academic repositories. Relevant studies published in Portuguese, English, and Spanish over the last ten years were included. Inclusion and exclusion criteria ensured the selection of high-quality studies focused on the efficacy of DBS in treating Parkinson's disease. The results demonstrated significant benefits of DBS in improving both motor and non-motor symptoms, with DBS showing superior efficacy compared to other treatments. The study concluded that DBS is a highly effective therapeutic approach for Parkinson's disease, offering substantial improvements in patient quality of life and symptom management, highlighting the need for further research to optimize this treatment modality.
Análise de óleos ozonizados no controle de agentes causadores de periodontite canina
Authors: Cunha Juliana Egas Rodrigues da , Macente Beatrice Ingrid , Ribeiro Heigly Eduarda Silva , Mansano Cleber Fernando Menegasso , Frias Danila Fernanda Rodrigues
Published: July 2024

Esta pesquisa visou avaliar a eficácia de óleos ozonizados no controle in vitro de agentes causadores da periodontite canina. Foram selecionadas cepas de Staphylococcus aureus e Escherichia coli isoladas de cães diagnosticados com doença periodontal Grau 3. Para os testes de susceptibilidade foram utilizados óleos comerciais de oliva, girassol e coco ozonizados. As bactérias foram semeadas em placas de Petri contendo Ágar TSA e em seguida foram adicionados discos de papel filtro contendo 10, 15, 20 e 25μL de óleo ozonizado. As placas foram colocadas na estufa BOD a 37°C para incubação e procedeu-se a leitura em 24 horas, por meio da averiguação e medição de halos de inibição de crescimento. Os resultados obtidos foram tabulados e submetidos à análise de acordo com a avaliação pela escala de Duraffourd. O óleo ozonizado de oliva apresentou efeito inibitório frente a Staphylococcus aureus e o de girassol frente a E. coli isolados de cães com doença periodontal. Os microrganismos testados apresentaram baixa sensibilidade frente aos óleos ozonizados de girassol e oliva.  Conclui-se que, as cepas de Staphylococcus aureus e Escherichia coli isoladas de cães que apresentaram doença periodontal Grau 3, apresentam sensibilidade in vitro aos óleos ozonizados comerciais de oliva e girassol, nas quantidades a partir de 20 e 25 μL, respectivamente, devendo serem testados para maiores volumes.
Generation and registration of high harmonics at surface plasma in coherent wake
emission and relativistic oscillating mirror modes by high-power laser pulses
Authors: Mitrofanov A. V. , Rozhko M. V. , Nazarov M. M. , Yakushkin N. V. , Romanovskii Ya. O. , Voronin A. A. , Fedotov A. B. , Sidorov-Biryukov D. A.
Published: July 2024

A universal technique is developed for the detection of high harmonics generated by relativistic and
subrelativistic laser pulses irradiating a solid target. The characteristic features typical of two different
generation methods are analyzed: parametric generation in the mid-IR range and amplification of chirped
pulses in the near-IR range. Experimental spectra of harmonics in the range up to 35 nm were recorded. They
can be used as a source of coherent radiation in the extreme UV region.
Dependence of Temperature Conditions of Planetary Atmospheres in the Solar
System on the Length of the Annual Cycle
Authors: Mokhov I.I.
Published: July 2024

The results of a comparative analysis of various characteristics of the temperature conditions of the planetary
atmospheres in the Solar system and their dependence on orbital parameters, in particular on the length
and angular frequency of the annual cycle, are presented. In particular, the root dependence on the angular
frequency of the was noted. The dependence of the planetary equilibrium temperature in the cubic root form
of the angular frequency of the annual cycle is associated withKepler’s third law. For Venus, Earth, Mars,
Jupiter, Saturn, the root dependence of the scale height and tropospheric height on the length of the annual
cycle is manifested, and the atmospheric features of the planets most distant from the Sun — Uranus and
Neptune — are noted.
Tsunami Waves off the Southeastern Coast of Sakhalin Island Caused by the
Eruption of the Hunga–Tonga–Hunga–Ha’apai Volcano on 15 January 2022
According to Observations by Bottom Devices of Waves
Authors: Kovalev D. P. , Kovalev P. D.
Published: July 2024

The observation of waves (sea level oscillations) in the coastal water area of the southeastern coast of Sakhalin
Island was carried out from November 2021 to May 2022 using bottom-mounted high-precision ARW 14 K
devices with one second discreteness. The analysis of the obtained time series revealed the presence of
anomalous waves in the range of tsunami waves in January 2022. It is shown that the waves detected on
15 January 2022 with periods of 15 minutes–4 hours, significantly standing out above the background, are
associated with volcanic tsunami waves. Spectral analysis of the time series showed that the maximum in
the spectra of sea level oscillations found after the volcanic eruption is close to the period of the first mode
of the shelf seiche. This indicates that incoming tsunami waves excite shelf seiches in the coastal zone and
contribute to the generation of longshore and transverse seiches into Mordvinov Bay. Time series analysis made
it possible to establish that the spectral density of sea level oscillations for the time interval of the beginning
of the eruption of the Hunga–Tonga–Hunga–Ha’apai volcano from 21 December 2021 to 11 January 2022
significantly differs from the spectral density for the time of the Plinian volcanic eruption. An analysis of
the statistical characteristics of sea level oscillations performed on two–day series in the range of periods
1 min–4 h for background waves and tsunamis showed an increase in the rms by 3.5 times for a time series containing tsunami waves. It has been established that for background time series containing tsunami waves,
the coefficients of asymmetry and kurtosis differ little from“Gaussia” values. This indicates that the arrival
of tsunami waves from distant sources does not significantly disrupt the stationarity of the wave field in the
observation area.
EVOLUTION OF CHINA’S ANTI-CORRUPTION POLICY: PROBLEMS AND SOLUTIONS
Authors: MIKHAYLOVA O.V. , SHAO Z.
Published: July 2024

Combating corruption in rapidly developing countries is one of the key directions of state policy. Despite decades of research, no universal approach has been proposed that can guarantee a minimum level of abuse of power for personal gain. Governments of countries, considering successful experiences, have to develop unique management approaches to address this issue, taking into account the specific political system, sociocultural characteristics, and dynamics of economic development. The goal of this article is to trace the evolution of anti-corruption policies in China. The study has demonstrated that the party leadership promptly changed approaches to combating corruption, in line with the changing forms and scales of corruption, understanding its origins and causes at different stages of the country’s development. China has a zero tolerance policy towards any manifestations of corruption and is actively combating abuses in government agencies. China’s current anti-corruption policy in the territory uses coercive instruments.
Relevant factors and the student profile that result in dropout in higher education: A case study at the Federal Institute of Espírito Santo campus Itapina
Authors: Araújo Maria Rita Almeida Moraes , Moreira Raphael Magalhães Gomes , Casteluber Daniel Louzada , Vieira Larissa Haddad Souza , Nardi Julio Cesar , Teixeira Giovany Frossard , Bonjardim Laila Caetano , Dalto Hudson Augusto
Published: July 2024

School dropout consists of the definitive departure of the student without completing his or her original course. This work aimed to discuss reasons that led students between the years 2014 and 2016 to drop out of the higher education course of Agricultural Sciences at the Federal Institute of Espírito Santo. This research focused on investigating possible reasons for dropout that may be internal, that is, linked to the institution or linked to the personal situations of former students. Exploratory research of a qualitative nature was chosen, using tools for data collection and analysis quantitatively and qualitatively, in addition to the methodology of participatory observation. In the technical procedures, a questionnaire with objective questions was applied, based on a questionnaire used to measure the dropout of students from the institution. According to the answers obtained, it was inferred that the main reasons that led the students to drop out were the lack of recognition of the teaching profession, dissatisfaction with the contents and chosen course, dissatisfaction with their own academic performance, among others. It is necessary to emphasize that some of the above-mentioned answers disagree when taking into account that the highest dropout rates occur in the first semesters, showing that little persistence or support for the student in permanence in the course can also be a determining factor.
Epidemiological profile of pediatric patients with acute kidney injury: A literature review
Authors: França Joyce Helane Veras , Da Silva Thais Pereira Dias , Maia Mariana Pacheco , Silva Gabriela Santos , Teixeira Andréia Morais , Teixeira Paulo Humberto , Cunha Tainá Galvão , Lemos Karine Cardoso
Published: July 2024

Objective: To identify the epidemiological profile of hospitalized pediatric patients who progressed to Acute Kidney Injury.  Method: A bibliographic survey was carried out through publications in indexed journals (MEDLINE, LILACS, SciELO, and PubMed), from 2007 to 2022, focusing on the topic in question. Results: In practically all studies, about 30% to 40% of AKI cases were due to sepsis and infection. Pediatric patients with sepsis and systemic multiorgan dysfunction had lower survival rates than those associated with other cases. Septic shock was associated with death in 62% of patients with AKI and was a risk factor for mortality. Conclusion: AKI is a severe disease, with a multifactorial etiology in many cases, and with variable mortality, which can reach more than 60% in dialysis patients. From an epidemiological point of view, there is still a significant lack of robust studies on the incidence, prevalence, and outcomes of AKI in the pediatric population.
Guia Completo para Barbearias
Authors: Souza Marcos
Published: July 2024

O "Guia Completo para Barbearias" de Marcos Souza é uma obra abrangente que serve como um manual detalhado para profissionais da área de estética e cuidados pessoais. O livro aborda desde os fundamentos básicos da barbearia até técnicas avançadas, proporcionando uma visão completa e prática para aqueles que desejam se destacar no setor. A obra inclui bibliografia, o que facilita a consulta e o aprofundamento em temas específicos.
Update on diagnostic techniques in leishmaniasis
Authors: Cobo Carrasco Lorena Elizabeth , Pérez Laborde Elena Johanna
Published: July 2024

Leishmaniasis is a persistent disease caused by the bite of a sandfly carrying the Leishmania parasite. Clinical manifestations include lesions of the skin, mucous membranes and internal organs. Parasite diagnosis is characterized by direct observation of the parasite by staining methods. Immunological tests determine the patient's humoral response. Molecular tests, such as conventional PCR, identify the subgenome and genome of the parasite by amplification of a specific DNA or RNA sequence. This research provides a set of techniques applicable to the diagnosis of leishmaniasis, with the loop-mediated isothermal amplification method (LAMP) being a rapid DNA or RNA sequence amplification test that does not require sophisticated equipment and has a sensitivity and specificity of 100 %.  In addition, the efficacy of artificial intelligence using database-driven algorithms to diagnose cutaneous Leishmania was examined. A literature review of scientific articles in databases such as PubMed, SciELO and Elsevier was carried out to perform a descriptive analysis of current and future diagnostic methods in Leishmaniasis
Development Of Stem Integrated Lkpd to Improve the Critical Thinking Ability of Class X Students
Authors: Syarif Ratih Ulfah R , Prasetyo Erwin , Donuata Pujianti Bejahida
Published: July 2024

This study aims to develop STEM-integrated LKPD in order to train students' critical thinking skills on Newton's law of gravity material so that it is feasible to use. The feasibility of LKPD is seen from the validity, practicality and data n-gain index. The research method used is a 4-D development model consisting of Define, Design, Develop, and Disseminate, but in this study it only reached the develop stage. The validity of LKPD is seen from completeness, content, presentation and language. Practicality can be seen from the responses and activities of students when learning using LKPD. This effectiveness can be seen from the increase in the test results of students' critical thinking skills which were tested limited to 28 students. Research data were analyzed in a quantitative descriptive manner. The results of the validity of LKPD are stated to be very valid with a percentage of 88.9%. LKPD is stated to be very practical with a percentage of 90%. The results of increasing critical thinking skills are expressed by an average n-gain score of 0.61 in the Medium category. From the results of the validity, practicality and n-gain index data, the LKPD developed is feasible to use.
Kentsel Kamusal Mekânın Üretiminde Değişkenlerin Gelişimi
Authors: Güneş Bülent
Published: July 2024

Giriş ve Çalışmanın Amacı: Modernist hareketin kentsel kamusal mekânlarda, II. Dünya savaşı ve 70’li yılların sonrasında 21.yy’a da taşan post modern düzenin popüler kültür ile beslenen meta üretimine dönüşümü, günümüzde de izlenmektedir. Bu devinimin tüm değişkenleri, kamusal mekânlar başta olmak üzere yeni dönem tasarım anlayışını adeta ütopyaların sonu olarak tanımlamıştır. Çalışmada post modern dönemin her şeyin değiştiğine ilişkin söylemi içinde değişmeden kalanlar sorgulanmıştır.
Kavramsal/Kuramsal Çerçeve: Kentsel kamusal mekân kavramı çalışmada bir arada kullanılmıştır. Kentsel alanın bütününün kamusal alan niteliği taşıması gereği kavramsal olarak temel alınmıştır. Çalışma bu kuramsal yaklaşım temelinde diğer sosyal kuramlar, toplum bilim verileri, üretim biçimi ve sosyal aktörlerle birlikte dönemsel olarak değerlendirilmiştir. Araştırma değişim adı altında mevcudun meşruiyetini sağlayan gelişmeleri tanımlayarak, kentsel mekândaki olgulara mimarlık ve planlama alanlarının mekânsal organizasyonlarına katkı verecektir.
Yöntem: Konu ile ilgili geniş literatür taramasının verileri yanı sıra son dönemde çok sayıda uygulamanın sonuçlarını kentsel mekânda gözlemlemek de mümkün olmuştur. Çalışmada farklı veri tabanlarındaki kuramsal verilerin olagelen süreçle bağlantıları analiz edilmiştir. İnternet kaynaklı adreslerden elde edilen görsel veriler ve bilgiler diğer gözlemlerle birlikte yorumlanmıştır. İstanbul metropol alanındaki örneklerde farklı kamusal alanlar ve sınırlarındaki dinamikler üzerinden değişen ve değişmeyen olgular ve yeni biçimleri araştırılmıştır. Makalede bu bütün ve parçaların ilişkisel bağlamı üzerinden sentezler oluşturmuştur.
Bulgular: Neoliberal ekonominin kültürel politikaları, yaşanan ekonomik krizlerin aşılmasında geç modernizm sürecinde yeni teknolojik gelişmeler ve dijital ortamla birlikte kentsel mekânların değişim ve dönüşümünde etkili olmuştur. Mimarlık ve planlama disiplinlerinin süreçle bütünleşen kuramsal dünyası ve uygulamaları sistemin meşruiyetine katkı vermiştir. Dolayısıyla sistemin değişmeyen değişim değeri olgusu yeni biçimleriyle kentsel mekânda egemenliğini sürdürmüş ve sürece uygun sosyal aktörlerini ve yaşam biçimini ortaya çıkarmıştır.
Sonuç: Neoliberal ekonominin yeni kültürel ortamı ve dijital teknolojili üretim ağı içinde kentsel kamusal mekânların yeni değişkenleri, bir bakıma sistemin değişmeyen temel değişkenlerinin ‘sürdürülebilirliğini’ sağlamaktadır. Küresel politikalar ‘Post politik’ teoriler ve mikro ölçekli yaklaşımlarla mimarlık ve planlama alanlarına yeni bir zemin hazırlamıştır. Gerek kentsel alanın kamusal mekânları ve gerekse yeni yerleşimler, yeni sınırlarda daha az geçirgen ve daha çok kapanan alanlar ile adeta özerk yapı adaları üretmektedir. Kentsel kamusal mekânlarda kullanım değerini arttıran yeni makro politikalar aranması kaçınılmazdır.
Nesnesiz Sanatın Mekânda Sergilenmesi
Authors: Pelvanlar Efe Mustafa
Published: July 2024

Giriş ve Çalışmanın Amacı: Nesnesiz sanat, yapıtın içeriğini oluşturan kavramın ön planda bulunduğu sanat üretim düşüncesidir. Nesne varlığının bulunmadığı sanat yapıtı, fiziksel varlığını ortadan kaldırarak düşünce odaklı bir yaklaşım içerisinde gerçekleşmektedir. Sanatın salt niteliksel özelliklerinin bulunduğu, görünen ile görünmeyen arasında gerçekleşen ilişki içerisinde sanat yapıtı varlığını göstermektedir. Araştırmanın amacı; nesnesiz sanat düşüncesini mekân ile ilişki içerisinde irdeleyerek, nesne varlığının bulunmadığı bir sanat yapıtının nasıl sergilenebileceğini sorgulamak ve sanatın mekân ile olan kavram ilişkisine dair önermeler sunmaktır.
Kavramsal Çerçeve: Nesnesiz sanatın mekânda sergilenmesi, sanat – mekân ilişkisi temel alınarak incelenmesi gerçekleştirilmiştir. Nesnesiz sanatın, mekân kavramını nasıl algıladığı ve mekânın varlığı ile hangi kavramsal düşüncelerin yaratıldığı incelenmektedir.
Yöntem: Konu ile ilgili literatür taraması doğrultusunda sanat ve mekân ilişkisi üzerine araştırma gerçekleştirilmektedir. Çalışma devamında ise “Nesnesiz Sanat Düşüncesi” ve “Nesnesiz Sanat ve Mekân İlişkisi” üzerine inceleme yapılmaktadır. Bulgular bölümünde sanat yapıtının içeriğini oluşturan deneyim ve düşünce odaklı sergiler incelenmektedir. Bu bağlamda Yves Klein’ın “Boşluk” ve Fernandez Arman’ın “Doluluk” sergileri örnek olarak alınmaktadır. Bununla birlikte nesnesiz sanat adına düşünce odaklı, yapıtı sürdürebilme adına anıtlar üzerinden örnek verilmektedir. Anlama dayalı olan sanat yapıtının, görsel bir nesne bulundurmadan sergilenme olanağının nasıl olabileceği ve mekân ile ilişkisinin hangi bağlamda gerçekleştiği üzerine nitel bir araştırma yapılmaktadır.
Bulgular: Nesnesiz sanat düşüncesi içerisinde örnek alınan sergilemeler, mekân kullanımı ile sanatçıların ifadesini kavramsal boyuta ulaştırmaktadır. Sanatçılar, yapıtın içeriğini oluşturan anlamı göstermek için fiziksel bir nesne odağı sağlamamakta, bulunduğu yer ve mekân ile sanat yapıtının varlığını yaratmaktadır.
Sonuç: Çalışma bağlamında nesnesiz sanat ve mekân adına oluşan bütünleşik bir ilişki saptanmaktadır. Mekân kullanımı, sanat yapıtının içeriğine dâhil edilerek kavramsal bir düşünce yaratılmaktadır. Nesne varlığı bulundurmayan sanat yapıtının sergilenmesi ile mekân, yapıtın kendisini oluşturmaktadır. Nesnesiz sanatın sergilenmesi, mekânın anlam ve kavram odaklı bir doğrultuda yapıtın içeriğine dâhil olması ile gerçekleştirileceği sonucuna varılmaktadır.
The Image of Vienna in Johann Nepomuk Nestroy’s Opera Parody Robert der Teuxel
Authors:   Gnesin Russian Academy of Music, Vlasov Alexei A.
Published: July 2024

The article is devoted to the analysis of the image of Vienna in the parody Robert der Teuxel (1833) by the Austrian playwright and comedy writer Johann Nepomuk Nestroy (1801– 1862). The primary source of the play was Giacomo Meyerbeer’s opera Robert le diable, which had been presented to the Viennese public three months earlier. The main change that the playwright made in his play, compared to the original plotline, was the transfer of the action to the Austrian capital during the times of Nestroy’s life. Such a dramaturgical solution makes it possible for us to observe how the literary and musical side of the play has changed as the result of this. The image of Vienna presented by the playwright and the composer Adolf Müller Sr. who collaborated with him is researched through various codes: the geographical, the socio-economic, the cultural and the musical. The character of the Austrian capital is manifested through the inclusion in the text of the play of toponyms directly related to Vienna, some of its landmarks that carry allegorical meanings in the context of the plotline, vivid linguistic techniques, as well as the transformation of Meyerbeer’s characters into the colorful types of the inhabitants of the Viennese suburbs. In musical terms, the urban “entourage” is realized through the use of the genres iconic to Austrian culture: the dances (mainly the waltz and the ländler), marches and yodeling.
FACTORS INFLUENCING BRIDGE INSPECTION IN DEVELOPING COUNTRIES, CHALLENGES AND FUTURE DIRECTIONS: A SYSTEMATIC LITERATURE REVIEW
Authors: Arshad Tuba
Published: July 2024

Bridges are very important to promote economic growth, mitigate poverty, and address persistent environmental issues. With the construction of new bridges, it is crucial to have an effective bridge inspection procedure. But most developing countries are still struggling in this field. This review examines common factors affecting bridge inspection in developing countries and their impact on bridge condition and performance while exploring strategies to improve those factors in developing countries in a systematic review. A total of 172 articles were identified through an explorative search of Direct Scopus, Google Scholar, and hand-search with limitations of the years 2013 to 2024. Only 15 articles were considered and classified based on the related topic of research study and keywords, such as Inspection of infrastructure, Improvement of bridge inspection, maintenance, and developing countries related articles. The findings from previous research studies show that the factors budget, resources, policies/Laws/regulations, Bridge age, and transparency are the factors that influence bridge inspection practices in developing countries. It is important to work on these factors to improve bridge inspection in developing countries. The recommendations from previous studies that can improve these factors are exploring new funding sources, enhancing the training programs, introducing cutting-edge technologies, updating standard guidelines every year, developing a centralized online portal to give regular updates of inspection data, and advocating for long-term planning. Therefore, this analysis concludes that bridge inspection practices can be improved in developing countries by improving all those factors.
Pengaruh Metode Jarimatika Terhadap Kecepatan Berhitung Pada Mata Pelajaran Matematika Kelas II SDIT Mutiara Palabuhanratu
Authors: Siti Apsoh
Published: July 2024

Penelitian ini dilakukan dengan tujuan untuk mengetahui pengaruh metode jarimatika terhadap kecepatan berhitung mata pelajaran matematika pada siswa kelas II SDIT Mutiara Palabuhanratu. Metode yang digunakan yaitu kuantitatif dengan penelitian Non- equivalen Control Group Design Pretestt-Pretestt, yaitu memberi tes sebelum adanya perlakuan, kemudian memberi tes setelah adanya perlakuan dengan menggunakan metode jarimatika. Sampel penelitian ini adalah siswa kelas II (kelas a dan b) kelas A sebagai kelas kontrol dan B eksperimen. Penelitian dilaksanakan sebanyak 3 kali pertemuan. Teknik pengambilan data yang digunakan dalam penelitian adalah teknik tes dan dokumentasi.sementara itu Teknik analisis data yang digunakan adalah uji normalitas, homogenitas, hipotesis dan uji n-gain dengan spss versi25. Hasil penelitian menunjukkan bahwa dengan menggunakan metode jarimatika siswa lebih cepat menyelesaikan operasi menghitung tanpa perlu menggunakan coretan di buku tulis cukup dengan jari-jari tangan dan dengan gerakan jari tangan dapat menarik perhatian siswa sehingga siswa tidak cepat bosan. Dapat dilihat rata-rata pretest kelas eksperimen adalah 39 dan kelas kontrol 42,5. Setelah dibeikan perlakuan nilai rata-rata prottest kelas eksperimen adalah 77 sedangkan kelas kontrol 49.Peningkatan kecepatan berhitung bisa dilihat dari hasil pengujian hipotesis yang ternyata terdapat perbedaan dengan sig(2-tailed) pada kelompok eksperimen sebesar 0,000 yang berarti < 0,05 maka dapat disimpulkan bahwa H0 ditolak dan H1 diterima.dengan rata-rata waktu yang digunakan siswa dalam mengerjakan soal pretestt menit (kriteria kurang cepat) dan setelah diberi perlakuan rata-rata waktu yang digunakan dalam mengerjakan soal pretestt 45 menit (kriteria cepat). Oleh karena itu, dapat disimpulkan bahwa terdapat pengaruh positif antara metode jarimatika terhadap kecepatan berhitung siswa kelas II SDIT Mutiara Palabuhanratu
Adverse event costs of systemic therapies for metastatic colorectal cancer previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy and biologics in the US
Authors: Paly Victoria Federico , Dasari Arvind , Hubbard Joleen , Bekaii-Saab Tanios , Padukkavidana Thihan , Hernandez Luis
Published: July 2024

Aim:
The objective of this study was to compare adverse event (AE) management costs for fruquintinib, regorafenib, trifluridine/tipiracil (T/T) and trifluridine/tipiracil+bevacizumab (T/T+bev) for patients with metastatic colorectal cancer (mCRC) previously treated with at least two prior lines of therapy from the US commercial and Medicare payer perspectives.
Materials & methods:
A cost-consequence model was developed to calculate the per-patient and per-patient-per-month (PPPM) AE costs using rates of grade 3/4 AEs with incidence ≥5% in clinical trials, event-specific management costs and duration treatment. Anchored comparisons of AE costs were calculated using a difference-in-differences approach with best supportive care (BSC) as a common reference. AE rates and treatment duration were obtained from clinical trials: FRESCO and FRESCO-2 (fruquintinib), RECOURSE (T/T), CORRECT (regorafenib) and SUNLIGHT (T/T, T/T+bev). AE management costs for the commercial and Medicare perspectives were obtained from publicly available sources.
Results:
From the commercial perspective, the AE costs (presented as per-patient, PPPM) were: $4015, $1091 for fruquintinib (FRESCO); $4253, $1390 for fruquintinib (FRESCO-2); $17,110, $11,104 for T/T (RECOURSE); $9851, $4691 for T/T (SUNLIGHT); $8199, $4823 for regorafenib; and $11,620, $2324 for T/T+bev. These results were consistent in anchored comparisons: the difference-in-difference for fruquintinib based on FRESCO was -$1929 versus regorafenib and -$11,427 versus T/T; for fruquintinib based on FRESCO-2 was -$2257 versus regorafenib and -$11,756 versus T/T. Across all analyses, results were consistent from the Medicare perspective.
Conclusion:
Fruquintinib was associated with lower AE management costs compared with regorafenib, T/T and T/T+bev for patients with previously treated mCRC. This evidence has direct implications for treatment, formulary and pathways decision-making in this patient population.
RESPONSE SURFACE TECHNIQUES AS AN INEVITABLE TOOL IN OPTIMIZATION PROCESS
Authors: Odunayo Olabinjo Oyebola
Published: July 2024

Response Surface Methodology (RSM) involves the construction and analysis of mathematical models to depict the relationship between input variables and the response of a system or process. This method circumvents the need for exhaustive experimentation by strategically designing a limited set of experiments while maximizing the information gathered. Experimentation and optimization are integral processes across various scientific disciplines. The utilization of Response Surface Models (RSMs) has emerged as an indispensable tool in achieving optimal experimental outcomes. The foundational understanding of RSM involves its core components, emphasizing the relationship between independent variables and their impact on a response of interest by employing statistical techniques. RSM enables researchers to comprehend the intricate behavior of systems, identify critical factors influencing the response, and subsequently optimize the process. Response surface techniques facilitates not only the improvement of processes but also the minimization of costs, reduction of waste, enhancement of product quality, facilitating efficient exploration and analysis of complex systems. Response surface analysis could be explore in all fields to generate optimal condition for all the variables in an experiment.
MATHEMATICAL MODELLING OF PREY AND PREDATOR SPECIES WITH TWO AGE GROUPS OF PREY POPULATION
Authors: Saxena V. P. , Dhurve Lalita
Published: July 2024

In this paper we developed mathematical model of prey and predator wild life population of finite size. We consider a prey population can be divided into two age groups. One part of prey species are adults and other part of prey species are juveniles or infants. A mathematical framework has been generated in terms of a system of nonlinear difference equations including all the significant parameters like generation wise per capita birth and death rates, migration of animals of second age group and transition from one age group to another. The solution are worked out in terms of finite multi variable polynomials. If the parameters manipulated by adjusting birth rate etc. in controlled environment in such a way that the polynomials match with standard polynomials in special functions then mathematical analysis can be easily carried out. This can be fruitful in wild life management. Here Numerical computations have been made for the change of populations in successive generations and different values of the parameters. Graphs have been plotted to depict the comparative variations.
Keterkaitan Istilah Pendidikan Islam : Tarbiyah, Ta'lim dan Ta'dib Dalam Al-Qur'an (Analisis Tafsir Ibnu Katsir)
Authors: Yani Yuli
Published: July 2024

Pendidikan Islam memiliki istilah yang berbeda-beda, adapun istilah dalam pendidikan Islam yaitu tarbiyah, ta'lim dan ta'dib. Dalam Al-Qur'an, istilah-istilah pendidikan tadi dijelaskan didalam QS. Al-Isra (17): 24, QS. Al-Baqarah (2): 31, QS. Al-Qalam (68): 4, dalam penelitian ini mengkaji istilah pendidikan berdasarkan analisis tafsir ibnu katsir. Penelitian ini bertujuan untuk mengetahui keterkaitan antara istilah-istilah pendidikan dalam Islam serta makna dari setiap istilah pendidikan berdasarkan Al-Qur'an.Penelitian ini menggunakan metode kualitatif dengan pengumpulan data pada penelitian ini yaitu menggunakan studi kepustakaan (library research) dan menggunakan metode tafsir tahlili. Hasil analisa dari penelitian ini adalah ketiga istilah pendidikan dalam Islam memiliki titik tekan yang berbeda-beda, ta' lim titik tekannya pada penyampaian ilmu pengetahuan yang benar, tarbiyah fokus pada bimbingan anak agar memiliki potensi yang dapat terus berkembang, dan ta''dib titik tekannya pada tingkah laku dan akhlak yang baik. Ketiganya mendasari tujuan, metode, kurikulum pendidikan, dan manajemennya, yang akan menghantarkan anak didik menjadi yang “seutuhnya”, sehingga mampu mengarungi kehidupan ini dengan baik sekarang akan dapat datang dengan baik.
Colonial Elements in Krishnachandra's Short Stories
Authors: Sharif Shazia
Published: July 2024

Krishan Chandar is renowned short story fictional writer. He has woven his stories from the society and depicted the bitter realities in impressive style. In colonial era, Krishan observed its harsh impacts on layman’s life with the help of satitical realism and social consciousness, he becomes the writer of departion unaccomplished dreams and poverty of common masses due to imperialism and capitalisim. Having core affinity to progressive movement he wrote masterpiece with his artist mind. Mostly his characters are from bottom of society who are being crushed under the heavy boots of colonisess and imperialists.
Consciousness, affinity, imperialism, depitration, capitalisim
CONTRIBUIÇÕES DAS COOPERATIVAS DE RECICLAGEM NO CICLO DA LOGÍSTICA REVERSA: UMA REVISÃO DE LITERATURA
Authors: São Bento Maria Aparecida Teles de , Carneiro Etiene Santiago
Published: July 2024

A logística reversa é um modelo utilizado pelas organizações como forma de gerenciar os resíduos sólidos gerados por elas. No Brasil, com a parceria das cooperativas de reciclagem, é feita a devida coleta, separação e destinação correta dos produtos pós consumidos. Assim, este estudo tem como objetivo identificar as contribuições socioambientais da aplicação dos princípios da logística reversa por cooperativas de reciclagem. Para a busca de respostas, foi utilizada a pesquisa documental da Lei 12.305/10 - que institui a Política Nacional de Resíduos Sólidos (PNRS) - e uma revisão de literatura com caráter exploratório, a partir do qual foi possível dizer que as cooperativas de reciclagem cumprem seu papel, a partir do sétimo princípio do cooperativismo (interesse pela comunidade), consonante também com os objetivos previstos na PNRS. Dessa forma, tais empreendimentos contribuem com o ciclo reverso com a venda dos resíduos sólidos coletados, fato este que gera renda e trabalho para os cooperados e melhoria na qualidade de vida das suas famílias; além de contribuir com uma maior preservação ambiental.
Locke, Anger and the State
Authors: Numao Kei
Published: July 2024

While “anger” or “angry” are words often used to describe today’s societies and politics, they are not the ones commentators of Locke use when talking about his political theory. This article argues that anger is in fact at the heart of his political outlook, and that focusing on the passion helps us to see an important aspect of the state. Since little has been said in relation to Locke and anger, the article starts by examining how he defined, viewed and justified anger. The article shows how Locke conceptualized a problematic component of anger, revenge, in terms of retributive punishment, which, when proportionate, can be viewed positively. The article then shows how Locke placed and tamed anger in the hands of the state to solve the inconveniences that exist in the state of nature caused by it. The article thus sheds light on the state’s role as an anger manager.
NEUROLOGIA: Diagnósticos, Tratamentos e Cirurgias - Edição III
Authors: Barroso L. De Freitas Guilherme , Astrês Fernandes Márcia , La Puma Fabião Renata
Published: July 2024

A Neurologia é a uma subárea da Ciências da Saúde que contempla a prevenção, diagnóstico, tratamento e intervenções das doenças que afetam o sistema nervoso central e seus componentes diretos e indiretos, como por exemplo, órgãos periféricos,
Ottoman list of small livestock raised in Kadiluk Srebrenica in 1596
Authors: Bulić Dejan
Published: July 2024

In this paper was announceda list of villages that were engaged in the breeding of small livestock, in the area, that according to the Ottoman administrative division, was part of the kazâ of Srebrenica in the Sanjak of Smederevo. The census was carried out in 1596 and included 44 villages of the mentioned kazâ, i. e. the territories of today's municipalities ofBajina Bašta and Ljubovija, i. e. Azbukovica. The determined number of small livestock totaled 38,272 heads. The census enables the calculation of total quantities of individual livestock products. In the observed area were kept the autochthonous Sjenica-Pešter sheep and the Balkan goat of the higher areas. Bearing in mind their production potential, and after the percentage representation of sheep and goats in the mentioned part of kazâ of Srebrenica was established, the approximate annual production of milk, wool and goat's hair was estimated. Based on three models, the percentage of sheep and goats was determined. The first is based on the statistical data of the former Užice district - which mostly covered the observed part of the kazâ of Srebrenicain 1900. The second calculation method is based on one piece of data from the Dubrovnik archives on imports, and the third model is constract on archaeozoological data from the site of Gradina - Erčege (14th-15th century), near Ivanjica (third column of the table). The number of sheep and goat skins produced annually would be approximately the same as the number of recorded heads, while the approximate number of small livestock was used for food or trade. It should be kept in mind that the obtained values were calculated based on the number of livestock included in the census, while the real number of livestock in the observed area was probably higher
Correlation of HCT-ALB, SmtO2, CRT and LAC with renal impairment and prognosis in patients with septic shock
Authors: Liang Peipei , Wei Zhijian , Xia Junjie , Yu Feng
Published: July 2024

Background: This study investigates the correlation between the difference in hematocrit (HCT) and serum albumin (ALB) levels (HCT-ALB), muscle tissue oxygen saturation (SmtO2), capillary refill time (CRT), and blood lactate (Lac) with the severity of renal function damage and prognosis in patients with septic shock. Methods: Conducted from February 2022 to February 2024, this study included 116 septic shock patients treated at the First Affiliated Hospital of Anhui Medical University. Patients were divided into groups based on whether they developed acute kidney injury: 40 patients were included in the acute kidney injury group, and the remaining 76 were placed in the non-kidney injury group. The levels of HCT-ALB, SmtO2, CRT, and Lac were compared between the groups. Patients were followed up to assess their 28day survival outcomes; 75 surviving patients were placed in the survival group, and 41 deceased patients were in the death group. Differences in clinical data and levels of HCTALB, SmtO2, CRT, and Lac between the two groups were analyzed to explore the relationship of these indicators with patient prognosis. Results: Levels of HCT-ALB, CRT, and Lac were higher, while SmtO2 was lower in the acute kidney injury group compared to the non-kidney injury group (P<0.05). Similarly, the death group exhibited higher levels of HCTALB, CRT, and Lac and lower SmtO2 levels compared to the survival group (P<0.05). Univariate and multivariate analyses revealed that HCT-ALB, SmtO2, CRT, and Lac significantly impact patient survival outcomes, demonstrating high predictive value for patient mortality with respective AUC values of 0.834, 0.782, 0.903, and 0.918. The combined application of these indicators for predicting patient mortality had an AUC value of 0.985, which is higher than when the indicators were used individually. Conclusions: HCT-ALB, SmtO2, CRT, and Lac are significantly elevated in patients with acute kidney injury and deceased patients, closely correlating with the severity and prognosis of septic shock. These indicators can serve as essential biomarkers for assessing the condition and prognosis of these patients.
ՀԱՅԱՍՏԱՆԻ ՀԱՆՐԱՊԵՏՈՒԹՅԱՆ ԱԶԳԱՅԻՆ ԱՆՎՏԱՆԳՈՒԹՅՈՒՆԸ ՍԱՀՄԱՆԱԴՐԱԿԱՆ ԿԱՐԳԱՎՈՐՈՒՄՆԵՐԻ ՀԱՄԱՏԵՔՍՏՈՒՄ / NATIONAL SECURITY OF THE REPUBLIC OF ARMENIA IN THE CONTEXT OF CONSTITUTIONAL REGULATIONS
Authors: Khachatryan Ashot , Yengibaryan Gor
Published: July 2024

The article discusses the issue of legal provision of national security of the
Republic of Armenia in the context of constitutional regulations. The author
presents some basic laws that are included in the legislative system formed in
the field of national security, emphasizing the role of the Constitution in that
system, presenting it as the main legal document in the hierarchical scale of
legal acts ensuring the country's security.
According to the author's observations, dangers and threats are always present
for people, society and the state, so for them, the security is a state of constant
protection from dangers. At the same time, it should be noted that it is not a
passive, but an active state. That is, a state characterized by such active actions
that ensure the progressive development of the person, society and the state
in all spheres of public life. As a result, the national security system acquires a
complex structure, in which component parts and subsystems can be
distinguished. Among the latter, the author singled out the system of legal
support and concluded that despite the extensive work done in the field, the
constitutional and legal framework of national security needs to be made
more complete and systematic, which will be greatly facilitated by the
adoption of the Law on Security of the Republic of Armenia.
The Rule of Law and the United Nations Summit of the Future
Authors: Birkenkötter Hannah
Published: July 2024

Is the rule of law an unwritten principle for the UN system? Today, rule of law language has been gradually replaced by a new paradigm of ‘inclusivity’. The rule of law debate within the UN was centered on a thick understanding of the rule of law, highlighting substantive values rather than procedural guarantees. Absent a consented definition of the term, the rule of law was never considered to be an unwritten principle for the UN system.
Propaganda Mission Command: a comparative social media analysis between the Badri Force 313 and the PMC Wagner
Authors: Borgonovo Federico , Porrino Giulia
Published: July 2024

Between 2021 and 2023 we have witnessed two major military operations, both relating to the field of hybrid conflict: the Taliban conquest of Afghanistan and the Russo-Ukrainian War. Two military units stood out, respectively, the Badri Force 313 and the PMC Wagner. Both units proved the existence of a strong propaganda component combined with operations conducted on the ground. This paper aims to highlight through two comparative case studies, the existence of a new parameter that joins the operational capacity, that is, Propaganda Mission Command. This tool has been observed within the respective digital ecosystems and has had serious tactical-strategic repercussions within the combat theatres. The online communication of the two military apparatuses influenced recruitment, funding, and even the public’s knowledge of the conflict. Finally, the use of propaganda in both these units contributed to the development of a new concept of Auftragstaktik that involves the communicative sphere. The existence of such a phenomenon should stimulate public and academic debates regarding the new nature of conflicts. Conflicts in which, as we observed, the propaganda/communication component is now indivisible from the military one and can result in remarkable operational and/or strategic advantages. The analysis of this hybrid tool is also meant to underline its difference from classic state propaganda. The two case studies show a different kind of “Propaganda Mission Command” that is framed within a military context, is related to “branded” units, and can shift the balance of conflicts towards one specific side through influence and psyops.
Perkembangan Masa Puber
Authors: Kartika Mawar Nurhaliza  , Nelfa Tri Safitri  , Linda Yarni
Published: July 2024

This research explores and evaluates Puberty, which is a time when a child experiences physical and emotional changes that indicate sexual and reproductive maturity. Puberty usually lasts around 9-14 years for girls and 12-16 years for boys. Hormonal changes during puberty cause various physical changes, such as breast growth, the appearance of acne, pubic hair, and height. Hormonal changes also cause emotional development, identity, and reproductive abilities. Deviant maturity can be caused by various factors, such as genetics, hormonal disorders, problems with the pituitary or thyroid gland, chromosomal disorders, eating disorders and so on. Early puberty can increase the risk of disease. Teenagers can experience the development of different characteristics, such as changes in body posture, height, and bone growth.
Integración de saberes: la influencia de los fundamentos de enfermería en la evolución del modelo de atención de salud ecuatoriano
Authors: Salán Negrete Lisbeth Patricia
Published: July 2024

El Modelo de Atención Integral de Salud en Ecuador ha evolucionado su enfoque, pasando de uno biologicista a uno integral. Este cambio está orientado hacia la atención primaria y centrada en la persona, la familia y la comunidad. Considera a la persona en su totalidad, incluyendo aspectos físicos, mentales, socioculturales y ambientales. Se llevó a cabo una revisión bibliográfica con el fin de identificar la relación entre los aportes teóricos de enfermería y el modelo de atención de salud ecuatoriano. Se utilizaron 62 documentos en la elaboración de este estudio. Se destacaron algunas teorías como la de Nola Pender, Dorothea Orem y Madeleine Leininger como las más relevantes en este contexto. A pesar de los avances, la implementación del MAIS enfrenta desafíos como la necesidad de fortalecer la formación de profesionales en atención primaria, mejorar la infraestructura de salud en áreas rurales, entre otros. Además, es crucial que los profesionales contemplen tácticas para mejorar la atención de enfermería. Estas pueden incluir la personalización de los cuidados, una comunicación efectiva, la promoción de la atención domiciliaria y el uso adecuado de herramientas de evaluación. Lo anterior, respaldado por un modelo teórico que sustente los cuidados en evidencia científica y pensamiento crítico.
Barreras y facilitadores de la duración de lactancia materna exclusiva en una IPS de primer nivel del municipio de Palermo
Authors: Molina Lasso Ruby Lorena , Esteban Castellanos Laura Viviana
Published: July 2024

Antecedentes: la OMS recomienda que los niños sean alimentados exclusivamente con leche materna durante los primeros 6 meses de vida. Esta práctica protege contra infecciones y favorece la salud nutricional.
Objetivo: identificar las barreras y facilitadores de la duración de lactancia materna exclusiva durante los primeros 6 meses de vida en una IPS primaria del municipio de Palermo.   
Métodos: se realizó una encuesta a 144 madres de niños menores de 6 meses que vivían en el área urbana y rural de Palermo (Huila, Colombia), que ingresaron por valoración integral de la ruta de promoción y mantenimiento de la salud durante el primer semestre del año 2022.
Resultados: la posibilidad de practicar lactancia materna exclusiva en las madres adolescentes entre 14 y 17 años fue 1,58 veces más que en las madres en curso de vida de juventud o adultez (p<0,01; RP=1,58 IC: 95% 0,01 – 0,53).
Conclusiones: se encontró una asociación estadísticamente significativa entre las madres que tenían conocimiento sobre los beneficios de la lactancia materna y la práctica del amamantamiento exclusivo. El uso de biberones o chupos disminuye la posibilidad de que las madres se adhieran a la práctica de la lactancia materna exclusiva (p<0,01; RP=0,074 IC: 95% 0,02 – 0,22). El suministro de información por parte del personal de salud sobre la lactancia materna aumenta 2 veces la posibilidad de practicar la lactancia materna exclusiva, sin embargo, esta asociación no es estadísticamente significativa.