bluuebunny/crossref_metadata_2025 huggingface dataset:
Numerical and Experimental Study on Hot Forming by Partition Cooling of 38MnB5Nb
Authors: Liang Xiao , Li Xianjun , Wang Decheng , Lin Xiyue , Luo Ping , Tan Zhunli , Song Yong , Tian Yu , Hou Junqing , Jiang Chao , Bian Yi , Xie Huasheng
Published: May 2022

Tailored properties hot forming of 38MnB5Nb by partition cooling can be configured on-demand. A gradient distribution microstructural characteristic can be generated by undertaking an appropriate cooling-tempering process for the regions with different properties requirements before forming. A unified viscoplastic constitutive model coupled with the primary cooling temperature and related material constants is established based on genetic algorithm. Meanwhile, the use of the mixture of jet air and dry ice particles to cool the partition region is essential to achieve different primary cooling temperatures. In this paper, the inverse heat conduction problem is solved to obtain the relationship between the interfacial heat transfer coefficient and different cooling conditions in the partition cooling process. The U-shaped part is taken as an example to simulate the change of temperature, stress-strain, thickness, and spring-back in the process of partition cooling and tailored hot forming properties. The results show that the gradient microstructural characteristic formed by partition cooling has a great influence on the stress field distribution. The maximum stress of 345 MPa can be reached after complete pressure holding in the partition slow cooling tailored properties of the hot forming process. The maximum stress can reach 743 MPa in the partition fast cooling tailored properties of the hot forming process due to the relatively high deformation resistance of the tempered martensite at the bottom center. The maximum residual stress in the two processes after spring-back drops to 305 MPa and 545 MPa, respectively. The spring-back is small under the two processes, with a maximum spring back angle of no more than 1°.
Fluid Flow and Heat Transfer Behaviors under Non-Isothermal Conditions in a Four-Strand Tundish
Authors: Zhu Mingmei , Peng Sikun , Jiang Kunchi , Luo Jie , Zhong Yong , Tang Ping
Published: May 2022

In the continuous casting process, the fluid flow of molten steel in the tundish is in a non-isothermal state. Because of the geometric shape and process parameters of a multi-strand tundish, the fluid flow behavior of each strand is quite inhomogeneous, and the difference in temperature, composition and inclusion content between each strand is great, which directly affects the quality of the steel products. In this paper, the fluid flow, heat transfer phenomena and inclusion trajectories in a four-strand tundish with and without flow-control devices (FCDs) are investigated using a water model and numerical simulation in isothermal and non-isothermal conditions. The results show that natural convection has a significant influence on the flow pattern and temperature distributions of molten steel in the tundish. Without FCDs, the average residence times of the molten steel in the tundish obtained by the isothermal water model, non-isothermal water model and non-isothermal mathematical model were 251.2 s, 263.3 s and 266.0 s, respectively, and the dead zone volumes were 21.51%, 29.26% and 28.21%, respectively. With FCDs, the average residence times of the molten steel obtained by the isothermal water model, non-isothermal water model and non-isothermal mathematical model were 293.0 s, 304.0 s and 305.2 s, respectively, and the dead zone volumes were 43.98%, 50.23% and 52.78%, respectively. The flow characteristics of the molten steel in the tundish were different between the isothermal and non-isothermal conditions. Compared with isothermal conditions, the numerical simulation results were closer to the water model results in non-isothermal conditions. The trial results showed that the fluid flow in a tundish has a non-isothermal characteristic, and the results in non-isothermal conditions can better reflect the actual fluid flow and heat transfer behaviors of molten steel in a tundish.
Weldability of Molybdenum–Rhenium Alloy Based on a Single-Mode Fiber Laser
Authors: Zhang Liang-Liang , Zhang Lin-Jie , Yang Qing-Jie
Published: May 2022

Due to its high thermal conductivity and favorable machinability, molybdenum–rhenium (Mo–Re) alloys have huge prospects in the field of high-temperature heat pipes. However, the weldability of Mo–Re alloys has not yet been systematically investigated. Based on an orthogonal test, the influence law of the single-mode fiber laser welding parameters on the weld profile and the mechanical properties of the joints was studied. Furthermore, the existence mode and the distribution law of Re in the fusion zone (FZ) were explored using X-ray photoelectron spectrometer (XPS) and the electron backscattered diffraction (EBSD) system. The results showed that weld penetration and width are most significantly influenced by power, and that these increased with increasing power. The tensile strength of the Mo–Re alloy joints reached 250 MPa, and no obvious hardening was found in the FZ. Re in the FZ also appeared as ReO2, ReO3, and ReC, apart from the atomic state.
Surface Tension-Driven Flow and Its Correlation with Mass Transfer during L-DED of Co-Based Powders
Authors: Li Zhiyong , Yu Gang , He Xiuli , Li Shaoxia , Shu Zhuang
Published: May 2022

Laser direct energy deposition (L-DED) is one of the most promising additive manufacturing methods, which has been paid more and more attention in recent years. An improved heat and mass transfer model was developed here to analyze thermal behavior, driving force, surface tension-driven flow and its correlation with dilution during L-DED of Co-based powders to a 38MnVS substrate. Thermal behavior was firstly studied for its fundamental influence on fluid flow and mass transfer. Next, the roles of capillary force and thermal capillary force were characterized using both the dimensional analysis and simulation methods, and the mechanism of surface tension-driven flow was also qualitatively investigated. Finally, flow characteristics inside the melt pool were studied in detail and their correlation with the dilution phenomenon was analyzed based on the multi-component mass transfer model. The temperature gradient was found to be much larger at the front of the melt pool, and it took about 200 ms for the melt pool to reach a quasi-steady condition. Moreover, sharp changes in the curvature of the solid/liquid boundary were observed. Surface tension was demonstrated as the main driver for fluid flow and resulted in centrally outward Marangoni flow. Capillary force contributes to the reduction of the curvature of the free surface, and thermal capillary force (Marangoni force) dominated the Marangoni convection. Alloy elements from the powders, such as Co and Ni, were added to the front part of the melt pool and mainly diluted at the upper side of the rear region near the symmetric plane of the melt pool. Fundamental results in this work provide a valuable understanding of the surface tension-driven flow and its correlation with concentration dilution during the additive manufacturing process.
Mendelian Randomization Analysis Identifies Blood Tyrosine Levels as a Biomarker of Non-Alcoholic Fatty Liver Disease
Authors: Gobeil Émilie , Maltais-Payette Ina , Taba Nele , Brière Francis , Ghodsian Nooshin , Abner Erik , Bourgault Jérôme , Gagnon Eloi , Manikpurage Hasanga D. , Couture Christian , Mitchell Patricia L. , Mathieu Patrick , Julien François , Corbeil Jacques , Vohl Marie-Claude , Thériault Sébastien , Esko Tõnu , Tchernof André , Arsenault Benoit J.
Published: May 2022

Non-alcoholic fatty liver disease (NAFLD) is a complex disease associated with premature mortality. Its diagnosis is challenging, and the identification of biomarkers causally influenced by NAFLD may be clinically useful. We aimed at identifying blood metabolites causally impacted by NAFLD using two-sample Mendelian randomization (MR) with validation in a population-based biobank. Our instrument for genetically predicted NAFLD included all independent genetic variants from a recent genome-wide association study. The outcomes included 123 blood metabolites from 24,925 individuals. After correction for multiple testing, a positive effect of NAFLD on plasma tyrosine levels but not on other metabolites was identified. This association was consistent across MR methods and was robust to outliers and pleiotropy. In observational analyses performed in the Estonian Biobank (10,809 individuals including 359 patients with NAFLD), after multivariable adjustment, tyrosine levels were positively associated with the presence of NAFLD (odds ratio per 1 SD increment = 1.23 [95% confidence interval = 1.12–1.36], p = 2.19 × 10−5). In a small proof-of-concept study on bariatric surgery patients, blood tyrosine levels were higher in patients with NAFLD than without. This study revealed a potentially causal effect of NAFLD on blood tyrosine levels, suggesting it may represent a new biomarker of NAFLD.
Evaluation of Hypoglycemic and Antioxidant Activities of Soybean Meal Products Fermented by Lactobacillus plantarum FPS 2520 and Bacillus subtilis N1 in Rats Fed with High-Fat Diet
Authors: Huang Chung-Hsiung , Chen Chun-Lung , Shieh Chen-Che , Chang Shun-Hsien , Tsai Guo-Jane
Published: May 2022

The hypoglycemic and antioxidant activities of Lactobacillus plantarum FPS 2520 and/or Bacillus subtilis N1 fermented soybean meal (SBM) in rats fed a high-fat diet (HFD) were investigated by assessing plasma glucose levels, insulin resistance, and oxidative stress-induced organ damage. Supplementation with FPS 2520- and/or N1-fermented SBM (500 and 1000 mg/kg of body weight per day) to HFD-induced obese rats for 6 weeks significantly down-regulated the concentration of plasma glucose during the oral glucose tolerance test (OGTT), as well as the concentration of fasting plasma glucose, insulin, and the value of the homeostasis model assessment of insulin resistance (HOMA-IR). In addition, plasma and hepatic levels of malondialdehyde (MDA) were alleviated in rats fed fermented SBM, especially SBM fermented by mixed strains. Moreover, fermented SBM treatment reduced HFD-exacerbated increases in plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, and uric acid levels. Based on these results, we clearly demonstrate the effect of fermented SBM on improving insulin resistance and oxidation-induced organ damage. Therefore, it is suggested that fermented SBM has the potential to be developed as functional foods for the management of obesity-induced hyperglycemia and organ damage.
Beating of a Spherical Liquid Crystal Elastomer Balloon under Periodic Illumination
Authors: Cheng Wenyan , Cheng Quanbao , Du Changshen , Dai Yuntong , Li Kai
Published: May 2022

Periodic excitation is a relatively simple and common active control mode. Owing to the advantages of direct access to environmental energy and controllability under periodic illumination, it enjoys broad prospects for application in soft robotics and opto-mechanical energy conversion systems. More new oscillating systems need to be excavated to meet the various application requirements. A spherical liquid crystal elastomer (LCE) balloon model driven by periodic illumination is proposed and its periodic beating is studied theoretically. Based on the existing dynamic LCE model and the ideal gas model, the governing equation of motion for the LCE balloon is established. The numerical calculations show that periodic illumination can cause periodic beating of the LCE balloon, and the beating period of the LCE balloon depends on the illumination period. For the maximum steady-state amplitude of the beating, there exists an optimum illumination period and illumination time rate. The optimal illumination period is proved to be equivalent to the natural period of balloon oscillation. The effect of system parameters on beating amplitude are also studied. The amplitude is mainly affected by light intensity, contraction coefficient, amount of gaseous substance, volume of LCE balloon, mass density, external pressure, and damping coefficient, but not the initial velocity. It is expected that the beating LCE balloon will be suitable for the design of light-powered machines including engines, prosthetic blood pumps, aircraft, and swimmers.
Blood Parasites and Health Status of Hibernating and Non-Hibernating Noctule Bats (Nyctalus noctula)
Authors: Linhart Petr , Bandouchova Hana , Zukal Jan , Votýpka Jan , Baláž Vojtech , Heger Tomas , Kalocsanyiova Vendula , Kubickova Aneta , Nemcova Monika , Sedlackova Jana , Seidlova Veronika , Veitova Lucie , Vlaschenko Anton , Divinova Renata , Pikula Jiri
Published: May 2022

Co-existence of bats with a wide range of infectious agents relates to their co-evolutionary history and specific physiology. Here, we examined blood samples collected during hibernation and the post-hibernation period to assess the influence of trypanosomes and babesias on the health status of 50 Noctule bats (Nyctalus noctula) using nested PCR. The impact of blood parasites on health was assessed by analysis of haematology and blood chemistry parameters in 21 bats. Prevalence of trypanosomes (Trypanosoma dionisii and T. vespertilionis) and babesia (Babesia vesperuginis) was 44% and 8%, respectively. Analysis of blood parameters indicated impact of babesia on acid–base balance. Blood chemistry parameters showed a significant decrease in total dissolved carbon dioxide and bicarbonate, increased anion gap, and no change in blood pH, suggesting compensated metabolic acidosis. Adverse effects of babesia were only apparent in hibernating bats. Our results suggest differences in the pathogenicity of trypanosomes and babesia in bats. While trypanosomes in general had no significant impact on the health status, we observed alterations in the blood acid–base balance in Babesia-infected bats during hibernation. Despite being infected, Babesia-positive bats survived hibernation without showing any clinical signs.
New Petro-Geochemical Data on Carboniferous Mafic Rocks in the Achemmach Area (NW, Fourhal Basin-Moroccan Central Massif)
Authors: Mezougane Hafid , Aissa Mohamed , Essalhi Mourad , Moussaid Azizi , Souiri Muhammad , Touil Ahmed , Bilal Essaid , Souiah Mohamed
Published: May 2022

The Achemmach region is located 40 km to the SW from Meknes city and 6 km to the NE frm the Hammam mine. It is part of the Paleozoic massif of Central Morocco. The studied area is formed by two Paleozoic rock-types: (i) a meta-sedimentary sequence composed of Middle Visean limestone and shale-sandstone withflyschoid of Upper Visean-Namurian age, and (ii) a magmatic rock series represented by volcanic rocks (pillow-lavas), hypovolcanic rocks (dolerites) and olivine-bearing gabbros.Based on the emplacement model, structural framework, relative chronology and petrogeochemistry of the magmatic rocks, for the first time in this area we distinguish: (i) dm to m-sized greenish pillow-lavas, with sharp borders and radius fractures underlined by fine greenish pelitic sedimentary intercalations, indicating recurrent volcanic activity in short episodes. Plagioclases and pyroxenes (augite) microlites, and more rarely phenocrystals, are recognizable in a glassy matrix devoid of recognizable olivine. (ii) Deformed, metamorphosed and altered dolerites dikes intrude the Middle to Upper Visean shale-sandstone formations. They have an overall NE-SW direction with a NW dip. They are composed of sericitized plagioclases, associated with partially to totally amphibolitized pyroxenes, tourmaline with differentdegrees of chlorite substitution, rutile and opaque minerals, in a microliticmesostasis and (iii) olivine-bearing gabbros, outcropping in variable dimensions (a few meters to 20 m). The olivine-bearing gabbros have a granular texture and are mainly made of plagioclases, pyroxenes, olivine, titanite, rutile, apatite and opaque minerals. All igneous minerals have undergone different degrees of replacement by secondary minerals; plagioclases are sericitized and albitized, pyroxenes are amphibolitized and epidotized and olivine is serpentinized and chloritized. Thepetro-geochemical study of these magmatic bodies demonstrates that pillow-lavas basalts and olivine-bearing gabbros have an alkaline affinity, while dolerites are thought to have a transitional alkaline affinity (alkaline-tholeiitic). Therefore, these formations would have been set up in anorogenic intra-continental geodynamic context, corresponding to a basin magmatism in the little evolved opening.
Research on Factors Affecting Mine Wall Stability in Isolated Pillar Mining in Deep Mines
Authors: Guo Jiang , Cheng Xin , Lu Junji , Zhao Yan , Xie Xuebin
Published: May 2022

This study takes the Dongguashan Copper Mine as its engineering background. Based on the mechanical model of the mine wall under the trapezoidal load of the backfill, a comprehensive evaluation index is proposed, and its calculation equation is derived. On this basis, an orthogonal test is designed to explore the influence of mining design parameters on mine wall stability. The results show that the width of the mine wall is the main factor affecting its stability, and increasing the width of the mine wall can significantly improve its stability. When the width of the mine wall is kept above 4 m, its stability is better. When the mechanical parameters of the backfill are poor, the mine wall is prone to overturning failure. The width of the mine room has an influence on the multi-directional loading of the mine wall, but the influence on the stability of the mine wall is low. According to the regression equation calculation, the mine wall safety factor is about 1.46 under the design of G5 mining of Dongguashan Line 52, the stability of the mine wall is good after actual mining and the engineering application effect is ideal, which can provide a theoretical basis for the design of isolation pillar mining in deep mines.
Occurrences of Pd–Pt Bismuthotellurides and a Phosphohedyphane-Like Phase in Sulfide Veins of the Monchepluton Layered Complex, Kola Peninsula, Russia
Authors: Barkov Andrei Y. , Nikiforov Andrey A. , Barkova Larisa P. , Martin Robert F.
Published: May 2022

We describe occurrences of platinum-group minerals (PGM) and an uncommon mineral enriched in Cl, and provide a brief review of Cl-bearing minerals associated with basic–ultrabasic complexes. An unusual phosphohedyphane-like phase (~30 µm), close to CaPb4(PO4)3Cl, occurs in one of the PGM-bearing veins of massive sulfides in the Monchepluton layered complex, Kola Peninsula, Russia. These veins consist of varying amounts of pyrrhotite, pentlandite, chalcopyrite, pyrite and accessory grains of galena; they are fairly abundant in the heavy-mineral concentrate, as are small (<0.1 mm) grains of PGM: michenerite, sperrylite, Bi-enriched members of the merenskyite–moncheite series and kotulskite, also rich in Bi. The PGE mineralization is attributed to a low-temperature deposition at the hydrothermal stage. The pyromorphite–phosphohedyphane solid solution likely formed as a secondary phase under conditions of a progressive build-up of oxygen fugacity via oxidation reactions of a precursor grain of galena and involving Ca, as an incompatible component of the sulfides, in a medium of residual fluid enriched in Cl.
Suitability of Clinker Replacement by a Calcined Common Clay in Self-Consolidating Mortar—Impact on Rheology and Early Age Properties
Authors: Muhammad Abubakar , Thienel Karl-Christian , Sposito Ricarda
Published: May 2022

The use of a high amount of calcined clays as cement replacement presents a great challenge in designing self-consolidating concrete. This current attempt evaluates the influence of cement replacement with up to 40 vol.% by a calcined common clay (CC), dominated by 2:1 phyllosilicates in combination with a fixed limestone powder (LP) content on fresh and hardened properties of self-consolidating mortar (SC-M). The fresh properties of SC-M were investigated by mini-slump flow, V-funnel and rotational viscometer measurements. Setting and hardening behavior were observed via dynamic modulus of elasticity and plastic shrinkage. Hydration mechanisms were determined by isothermal calorimetry and thermal analysis. Hardened properties of SC-M were evaluated using compressive strength tests and mercury intrusion porosimetry (MIP). The results revealed a decreased rate of deformability in SC-M when cement is substituted increasingly by CC and a rising superplasticizer (SP) demand, but indicated an improved stability of SC-M even at a higher dosage of SP and hardly any impact on the setting behavior. CC enhanced the precipitation of monocarboaluminate phases and thereby refined the pore size distribution of the binder matrix. SC-M can be produced with up to 40 vol.% CC as cement replacement without having effect on its 28 days mechanical properties.
On the Morphology and Geochemistry of Hydrothermal Crypto- and Microcrystalline Zircon Aggregates in a Peralkaline Granite
Authors: Vlach Silvio R. F.
Published: May 2022

Singular crypto- and microcrystalline hydrothermal zircon aggregates occur in peralkaline granites from the Corupá Pluton of “A-type” granites and syenites in Graciosa Province, Southern Brazil, and are herein characterized for their morphological, textural and geochemical (major, minor and trace elements, and Lu-Hf isotopes) properties. The aggregates were found to present a variety of habits, such as dendritic, oolitic, botryoidal and spherulitic, and they are associated with typical hydrothermal minerals (alkali-feldspars, quartz, fluorite, epidote-group minerals, phyllosilicates and Fe oxides) in micro-fractures and small miarolitic cavities in the host rock. They precipitated directly from a hydrothermal fluid and, compared to magmatic zircon crystals from the host, were found to contain relatively high abundances of the “non-formula” elements (e.g., Fe, Al, and Ca) and HFSEs (High-Field-Strength Elements), particularly the L- and MREEs (Light and Medium Rare Earth Elements), features most typical of hydrothermal zircon, as well as high Th/U ratios, whereas the Lu-Hf isotopic signatures were found to be similar. The formation of the zircon aggregates and the associated epidote-groups minerals was probably due to the interaction between an orthomagmatic, F-bearing, aqueous fluid transporting the HFSEs with the host-rock and/or with an external meteoritic fluid from the country rocks. The preservation of an amorphous-like Zr-silicate compound and crypto-to-microcrystalline zircon varieties is arguably related to the inefficient fluid flux and/or elemental diffusion in a low-temperature oxidizing environment.
Optical Resolution of Two Pharmaceutical Bases with Various Uses of Tartaric Acid Derivatives and Their Sodium Salts: Racemic Ephedrine and Chloramphenicol Base
Authors: Bánhegyi Dorottya Fruzsina , Fogassy Elemér , Madarász János , Pálovics Emese
Published: May 2022

The optically active dibenzoyltartaric acid, tartaric acid, and its sodium salts were successfully applied to the optical resolution of (1R,2S)(1S,2R)-2-(methylamino)-1-phenylpropan-1-ol (EPH) and (1R,2R)(1S,2S)-2-amino-1-(4-nitrophenyl)propane-1,3-diol (AD) as resolving agents. It was observed that both compounds’ resolution using a mixture of salts of quasi-racemic resolving agents showed a change in chiral recognition under the same conditions compared to the result of the use of the single enantiomeric resolving agent. The changes are followed by detailed analytical (XRD, FTIR, and DSC) studies. Meanwhile, the DASH indexing software package was also tested on powder XRD patterns of pure initial materials and intermediate salt samples of high diastereomeric excess.
In Vitro and In Silico Evaluation of Cholinesterase Inhibition by Alkaloids Obtained from Branches of Abuta panurensis Eichler
Authors: da Silva Mesquita Rochelly , Kyrylchuk Andrii , Cherednichenko Anton , Costa Sá Ingrity Suelen , Macedo Bastos Lílian , Moura Araújo da Silva Felipe , Saraiva Nunomura Rita de Cássia , Grafov Andriy
Published: May 2022

Alkaloids are natural products known as ethnobotanicals that have attracted increasing attention due to a wide range of their pharmacological properties. In this study, cholinesterase inhibitors were obtained from branches of Abuta panurensis Eichler (Menispermaceae), an endemic species from the Amazonian rainforest. Five alkaloids were isolated, and their structure was elucidated by a combination of 1D and 2D 1H and 13C NMR spectroscopy, HPLC-MS, and high-resolution MS: Lindoldhamine isomer m/z 569.2674 (1), stepharine m/z 298.1461 (2), palmatine m/z 352.1616 (3), 5-N-methylmaytenine m/z 420.2669 (4) and the N-trans-feruloyltyramine m/z 314.1404 (5). The compounds 1, 3, and 5 were isolated from A. panurensis for the first time. Interaction of the above-mentioned alkaloids with acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes was investigated in silico by molecular docking and molecular dynamics. The molecules under investigation were able to bind effectively with the active sites of the AChE and BChE enzymes. The compounds 1–4 demonstrated in vitro an inhibitory effect on acetylcholinesterase with IC50 values in the range of 19.55 µM to 61.24 µM. The data obtained in silico corroborate the results of AChE enzyme inhibition.
Virtual Screening and Hit Selection of Natural Compounds as Acetylcholinesterase Inhibitors
Authors: Atanasova Mariyana , Dimitrov Ivan , Ivanov Stefan , Georgiev Borislav , Berkov Strahil , Zheleva-Dimitrova Dimitrina , Doytchinova Irini
Published: May 2022

Acetylcholinesterase (AChE) is one of the classical targets in the treatment of Alzheimer’s disease (AD). Inhibition of AChE slows down the hydrolysis of acetycholine and increases choline levels, improving the cognitive function. The achieved success of plant-based natural drugs acting as AChE inhibitors, such as galantamine (GAL) from Galanthus genus and huperzine A from Huperzia serrate (approved drug in China), in the treatment of AD, and the fact that natural compounds (NCs) are considered as safer and less toxic compared to synthetic drugs, led us to screen the available NCs (almost 150,000) in the ZINC12 database for AChE inhibitory activity. The compounds were screened virtually by molecular docking, filtered for suitable ADME properties, and 32 ligands from 23 structural groups were selected. The stability of the complexes was estimated via 1 μs molecular dynamics simulation. Ten compounds formed stable complexes with the enzyme and had a vendor and a reasonable price per mg. They were tested for AChE inhibitory and antioxidant activity. Five compounds showed weak AChE inhibition and three of them exhibited high antioxidant activity.
Efficient Oxidation of Cyclohexane over Bulk Nickel Oxide under Mild Conditions
Authors: Alnefaie Reem S. , Abboud Mohamed , Alhanash Abdullah , Hamdy Mohamed S.
Published: May 2022

Nickel oxide powder was prepared by simple calcination of nickel nitrate hexahydrate at 500 °C for 5 h and used as a catalyst for the oxidation of cyclohexane to produce the cyclohexanone and cyclohexanol—KA oil. Molecular oxygen (O2), hydrogen peroxide (H2O2), t-butyl hydrogen peroxide (TBHP) and meta-chloroperoxybenzoic acid (m-CPBA) were evaluated as oxidizing agents under different conditions. m-CPBA exhibited higher catalytic activity compared to other oxidants. Using 1.5 equivalent of m-CPBA as an oxygen donor agent for 24 h at 70 °C, in acetonitrile as a solvent, NiO powder showed exceptional catalytic activity for the oxidation of cyclohexane to produce KA oil. Compared to different catalytic systems reported in the literature, for the first time, about 85% of cyclohexane was converted to products, with 99% KA oil selectivity, including around 87% and 13% selectivity toward cyclohexanone and cyclohexanol, respectively. The reusability of NiO catalyst was also investigated. During four successive cycles, the conversion of cyclohexane and the selectivity toward cyclohexanone were decreased progressively to 63% and 60%, respectively, while the selectivity toward cyclohexanol was increased gradually to 40%.
Neuroprotective Effect of Dioscin against Parkinson’s Disease via Adjusting Dual-Specificity Phosphatase 6 (DUSP6)-Mediated Oxidative Stress
Authors: Mao Zhang , Gao Meng , Zhao Xuerong , Li Lili , Peng Jinyong
Published: May 2022

Exploration of lead compounds against Parkinson’s disease (PD), a neurodegenerative disease, is of great important. Dioscin, a bioactive natural product, shows various pharmacological effects. However, the activities and mechanisms of dioscin against PD have not been well investigated. In this study, the tests on 6-hydroxydopamine (6-OHDA)-induced PC12 cells and rats were carried out. The results showed that dioscin dramatically improved cell viability, decreased reactive oxygen species (ROS) levels, improved motor behavior and tyrosine hydroxylase(TH) levels and restored the levels of glutathione (GSH) and malondialdehyde (MDA) in rats. Mechanism investigation showed that dioscin not only markedly increased the expression level of dual- specificity phosphatase 6 (DUSP6) by 1.87-fold in cells and 2.56-fold in rats, and decreased phospho-extracellular regulated protein kinases (p-ERK) level by 2.12-fold in cells and 2.34-fold in rats, but also increased the levels of nuclear factor erythroid2-related factor 2 (Nrf2), hemeoxygenase-1 (HO-1), superoxide dismutase (SOD) and decreased the levels of kelch-1ike ECH-associated protein l (Keap1) in vitro and in vivo. Furthermore, DUSP6 siRNA transfection experiment in PC12 cells validated the protective effects of dioscin against PD via regulating DUSP6 to adjust the Keap1/Nrf2 pathway. Our data supported that dioscin has protection against PD in regulating oxidative stress via DUSP6 signal, which should be considered as an efficient candidate for the treatment of PD in the future.
Reversible Diels–Alder Addition to Fullerenes: A Study of Dimethylanthracene with H2@C60
Authors: Subhani Mahboob , Zhou Jinrong , Sui Yuguang , Zou Huijing , Frunzi Michael , Cross James , Saunders Martin , Shuai Cijun , Liang Wenjie , Xu Hai
Published: May 2022

The study of isolated atoms or molecules inside a fullerene cavity provides a unique environment. It is likely to control the outer carbon cage and study the isolated species when molecules or atoms are trapped inside a fullerene. We report the Diels–Alder addition reaction of 9,10-dimethyl anthracene (DMA) to H2@C60 while 1H NMR spectroscopy is utilized to characterize the Diels–Alder reaction of the DMA with the fullerene. Through 1H NMR spectroscopy, a series of isomeric adducts are identified. The obtained peaks are sharp, precise, and straightforward. Moreover, in this paper, H2@C60 and its isomers are described for the first time.
Investigations of 2D PtS2’s Saturable Absorption Characteristic and Its Optimization to OPO’s Operation
Authors: Hu Xinyu , Wang Jing , Guo Heze , Jiang Kai , Tang Wenjing , Xia Wei
Published: May 2022

A 6.2 nm-thickness platinum disulfide (PtS2) film was prepared by electron beam evaporation with post vulcanization. The nonlinear transmittance was measured by power scanning method and the modulation depth is fitted to be 13%. Based on the transmittance curve, saturable absorption parameters of PtS2 are calculated with inhomogeneously broadening mechanism, including 6.4298 × 10−19 cm−2 ground-state absorption cross-section, 2.5927 × 10−19 cm−2 excited-state absorption cross-section, and 1.043 ms excited-state lifetime. The PtS2 film combined with active time management was implemented to modulate the fundamental light of optical parametric oscillator (OPO). Owing to the nonlinear absorption property of PtS2, the operation of Q-switched OPO was optimized in both the experiment and dynamical theory. In particular, the conversion efficiency was experimentally improved by 13.2%. The pump-to-signal conversion efficiency went up to 3.29%, which is the highest conversion value reported so far. The theoretical values fit the experiment well, which are from the Gaussian rate equations with PtS2’s saturable-absorption characteristic.
Superconducting Bio-Inspired Au-Nanowire-Based Neurons
Authors: Skryabina Olga V. , Schegolev Andrey E. , Klenov Nikolay V. , Bakurskiy Sergey V. , Shishkin Andrey G. , Sotnichuk Stepan V. , Napolskii Kirill S. , Nazhestkin Ivan A. , Soloviev Igor I. , Kupriyanov Mikhail Yu. , Stolyarov Vasily S.
Published: May 2022

High-performance modeling of neurophysiological processes is an urgent task that requires new approaches to information processing. In this context, two- and three-junction superconducting quantum interferometers with Josephson weak links based on gold nanowires are fabricated and investigated experimentally. The studied cells are proposed for the implementation of bio-inspired neurons—high-performance, energy-efficient, and compact elements of neuromorphic processor. The operation modes of an advanced artificial neuron capable of generating the burst firing activation patterns are explored theoretically. A comparison with the Izhikevich mathematical model of biological neurons is carried out.
Synthesis of Titanium Nitride Nanoparticles by Pulsed Laser Ablation in Different Aqueous and Organic Solutions
Authors: Popov Anton , Tikhonowski Gleb , Shakhov Pavel , Popova-Kuznetsova Elena , Tselikov Gleb , Romanov Roman , Markeev Andrey , Klimentov Sergey , Kabashin Andrei
Published: May 2022

Owing to a strong photothermal response in the near-IR spectral range and very low toxicity, titanium nitride (TiN) nanoparticles (NPs) synthesized by pulsed laser ablation in liquids (PLAL) present a novel appealing object for photo-induced therapy of cancer, but the properties of these NPs still require detailed investigation. Here, we have elaborated methods of femtosecond laser ablation from the TiN target in a variety of liquid solutions, including acetonitrile, dimethylformamide, acetone, water, and H2O2, to synthesize TiN NPs and clarify the effect of liquid type on the composition and properties of the formed NPs. The ablation in all solvents led to the formation of spherical NPs with a mean size depending on the liquid type, while the composition of the NPs ranged from partly oxidized TiN to almost pure TiO2, which conditioned variations of plasmonic peak in the region of relative tissue transparency (670–700 nm). The degree of NP oxidation depended on the solvent, with much stronger oxidation for NPs prepared in aqueous solutions (especially in H2O2), while the ablation in organic solvents resulted in a partial formation of titanium carbides as by-products. The obtained results contribute to better understanding of the processes in reactive PLAL and can be used to design TiN NPs with desired properties for biomedical applications.
Sophisticated Structural Tuning of NiMoO4@MnCo2O4 Nanomaterials for High Performance Hybrid Capacitors
Authors: Di Yifei , Xiang Jun , Bu Nan , Loy Sroeurb , Yang Wenduo , Zhao Rongda , Wu Fufa , Sun Xiaobang , Wu Zhihui
Published: May 2022

NiMoO4 is an excellent candidate for supercapacitor electrodes, but poor cycle life, low electrical conductivity, and small practical capacitance limit its further development. Therefore, in this paper, we fabricate NiMoO4@MnCo2O4 composites based on a two-step hydrothermal method. As a supercapacitor electrode, the sample can reach 3000 mF/cm2 at 1 mA/cm2. The asymmetric supercapacitor (ASC), NiMoO4@MnCo2O4//AC, can be constructed with activated carbon (AC) as the negative electrode, the device can reach a maximum energy density of 90.89 mWh/cm3 at a power density of 3726.7 mW/cm3 and the capacitance retention can achieve 78.4% after 10,000 cycles.
Carbon-Based Nanocatalysts (CnCs) for Biomass Valorization and Hazardous Organics Remediation
Authors: Giannakoudakis Dimitrios A. , Zormpa Foteini F. , Margellou Antigoni G. , Qayyum Abdul , Colmenares-Quintero Ramón Fernando , Len Christophe , Colmenares Juan Carlos , Triantafyllidis Konstantinos S.
Published: May 2022

The continuous increase of the demand in merchandise and fuels augments the need of modern approaches for the mass-production of renewable chemicals derived from abundant feedstocks, like biomass, as well as for the water and soil remediation pollution resulting from the anthropogenic discharge of organic compounds. Towards these directions and within the concept of circular (bio)economy, the development of efficient and sustainable catalytic processes is of paramount importance. Within this context, the design of novel catalysts play a key role, with carbon-based nanocatalysts (CnCs) representing one of the most promising class of materials. In this review, a wide range of CnCs utilized for biomass valorization towards valuable chemicals production, and for environmental remediation applications are summarized and discussed. Emphasis is given in particular on the catalytic production of 5-hydroxymethylfurfural (5-HMF) from cellulose or starch-rich food waste, the hydrogenolysis of lignin towards high bio-oil yields enriched predominately in alkyl and oxygenated phenolic monomers, the photocatalytic, sonocatalytic or sonophotocatalytic selective partial oxidation of 5-HMF to 2,5-diformylfuran (DFF) and the decomposition of organic pollutants in aqueous matrixes. The carbonaceous materials were utilized as stand-alone catalysts or as supports of (nano)metals are various types of activated micro/mesoporous carbons, graphene/graphite and the chemically modified counterparts like graphite oxide and reduced graphite oxide, carbon nanotubes, carbon quantum dots, graphitic carbon nitride, and fullerenes.
Identification of a Novel Osteogenetic Oligodeoxynucleotide (osteoDN) That Promotes Osteoblast Differentiation in a TLR9-Independent Manner
Authors: Nihashi Yuma , Miyoshi Mana , Umezawa Koji , Shimosato Takeshi , Takaya Tomohide
Published: May 2022

Dysfunction of bone-forming cells, osteoblasts, is one of the causes of osteoporosis. Accumulating evidence has indicated that oligodeoxynucleotides (ODNs) designed from genome sequences have the potential to regulate osteogenic cell fate. Such osteogenetic ODNs (osteoDNs) targeting and activating osteoblasts can be the candidates of nucleic acid drugs for osteoporosis. In this study, the ODN library derived from the Lacticaseibacillus rhamnosus GG genome was screened to determine its osteogenetic effect on murine osteoblast cell line MC3T3-E1. An 18-base ODN, iSN40, was identified to enhance alkaline phosphatase activity of osteoblasts within 48 h. iSN40 also induced the expression of osteogenic genes such as Msx2, osterix, collagen type 1α, osteopontin, and osteocalcin. Eventually, iSN40 facilitated calcium deposition on osteoblasts at the late stage of differentiation. Intriguingly, the CpG motif within iSN40 was not required for its osteogenetic activity, indicating that iSN40 functions in a TLR9-independent manner. These data demonstrate that iSN40 serves as a novel osteogenetic ODN (osteoDN) that promotes osteoblast differentiation. iSN40 provides a potential seed of the nucleic acid drug that activating osteoblasts for osteoporosis therapy.
Mechanical Alloying Integrated with Cold Spray Coating for Fabrication Cu50(Ti50−xNix), x; 10, 20, 30, and 40 at.% Antibiofilm Metallic Glass Coated/SUS304 Sheets
Authors: Aldhameer Ahmad , El-Eskandarany Mohamed Sherif , Kishk Mohamed , Alajmi Fahad , Banyan Mohmmad
Published: May 2022

Antibacterial agents derived from conventional organic compounds have traditionally been employed as a biofilm protective coating for many years. These agents, on the other hand, often include toxic components that are potentially hazardous to humans. Multiple approaches have been investigated over the last two decades, including the use of various metallic and oxide materials, in order to produce a diverse variety of usable coating layers. When it comes to material coating approaches, the cold spray technique, which is a solid-state method that works well with nanopowders, has shown superior performance. Its capacity to produce unique material coating in ways that are not possible with other thermal methods is the primary reason for its importance in contemporary production. The present work has been addressed in part to explore the possibility of employing mechanically alloyed Cu50(Ti50−xNix)x; x = 10, 20, 30, and 40 at.% metallic glass powders, for producing an antibiofilm/SUS304 surface protective coating, using the cold spray approach. In this study, elemental Cu, Ti, and Ni powders were low-energy ball milled for 100 h to fabricate metallic glassy powders with different Ni contents. The as-prepared metallic glassy powders were utilized to coat SUS304 sheets, using the cold spraying process. With high nanohardness values, the as-fabricated coating material, in particular Cu50Ti20Ni30, demonstrated remarkable performance in comparison to other materials in its class. Furthermore, it displayed excellent wear resistance while maintaining a low coefficient of friction, with values ranging from 0.32 to 0.45 in the tested range. E. coli biofilms were formed on 20 mm2 SUS304 sheet coated coupons, which had been injected with 1.5 108 CFU mL−1 of the bacterium. With the use of nanocrystalline Cu-based powders, it is feasible to achieve considerable biofilm inhibition, which is a practical strategy for accomplishing the suppression of biofilm formation.
Technologies for Biological and Bioelectrochemical Removal of Inorganic Nitrogen from Wastewater: A Review
Authors: Paul Diplina , Banerjee Abhisek
Published: May 2022

Water contamination due to various nitrogenous pollutants generated from wastewater treatment plants is a crucial and ubiquitous environmental problem now-a-days. Nitrogen contaminated water has manifold detrimental effects on human health as well as aquatic life. Consequently, various biological treatment processes are employed to transform the undesirable forms of nitrogen in wastewater to safer ones for subsequent discharge. In this review, an overview of various conventional biological treatment processes (viz. nitrification, denitrification, and anammox) have been presented along with recent novel bioelectrochemical methods (viz. microbial fuel cells and microbial electrolysis cells). Additionally, nitrogen is an indispensable nutrient necessary to produce artificial fertilizers by fixing dinitrogen gas from the atmosphere. Thus, this study also explored the potential capability of various nitrogen recovery processes from wastewater (like microalgae, cyanobacteria, struvite precipitation, stripping, and zeolites) that are used in industries. Further, the trade-offs, challenges posed by these processes have been dwelt on along with other biological processes like CANON, SHARON, OLAND, and others.
Beneficial Effects of Walnut Oligopeptides on Muscle Loss in Senescence-Accelerated Mouse Prone-8 (SAMP8) Mice: Focusing on Mitochondrial Function
Authors: Fan Rui , Hao Yuntao , Du Qian , Kang Jiawei , Xu Meihong , Li Yong
Published: May 2022

Aging-related muscle loss is a hallmark of aging and is the cause of some negative outcomes. An optimized diet and supplements have a positive effect in slowing down the process of muscle loss. This study was designed to evaluate the beneficial effects of walnut oligopeptides (WOPs) on aging-related muscle loss and explore the possible underlying mechanism in Senescence-Accelerated Mouse Prone 8 (SAMP8) Mice. SAMP8 mice were randomly divided into four groups (n = 15/group), including one group which was the SAMP8 age control group and three groups those were WOP intervention groups. Meanwhile, Senescence Accelerated Resistant Mouse 1 (SAMR1) mice (n = 12), which had normal senescence rates, were used as model controls. During the six-month intervention period, the age control and normal control groups were given sterilized water, while the three WOP intervention groups were given WOP solution with low (110 mg/kg·bw), medium (220 mg/kg·bw) and high concentrations (440 mg/kg·bw), respectively. The results showed that WOPs could significantly increase muscle mass and improve physical performance (wire hang and catwalk behavioral tests) in aging mice. Moreover, WOPs could significantly reduce the levels of IL-1β, IL-6 and TNF-α in serum and gastrocnemius tissues and increase the mitochondrial DNA content, as well as the expression levels of AMPK, PGC-1α, NRF-1 and TFAM in the gastrocnemius muscle of aging mice, which was speculated to be the specific mechanism related to mitochondrial function improvement and inflammation reduction. These results indicate that WOPs can improve aging-related muscle loss, in term of both muscle mass and physical performance, and WOP supplements seems to be potentially effective in elderly individuals.
Postnatal Serum Total Thyroxine Level Associated with Short- and Long-Term Anthropometric Outcomes in Very Preterm Infants
Authors: Chen Yen-Ju , Chu Wei-Ying , Pan Yu-Wen , Wang Chen-Yueh , Chou Yen-Yin , Lin Chyi-Her , Tsuda Kennosuke , Iwata Osuke , Yu Wen-Hao , Lin Yung-Chieh
Published: May 2022

Thyroxine (T4) importantly regulates the growth of newborns. Compared to fetuses with equivalent gestational ages, very preterm infants (VPIs) often experience relatively low thyroxinemia, with a normal thyroid-stimulating hormone (TSH) concentration < 10 μIU/mL. However, there is continued debate regarding postnatal thyroxine supplementation for VPIs with normal TSH and transitionally low thyroxinemia. Little research has explored the role of the postnatal total T4 (TT4) serum concentration on the growth of VPIs. In this study, we aim to clarify whether the postnatal thyroxine concentration is associated with the short- and long-term growth outcomes of VPIs. A total of 334 surviving VPIs in our previously reported cohort, born in the period August 2007–July 2016, were enrolled. The exposure variable was the postnatal TT4 concentration at 1 month old. The primary outcomes were body weight increments over 28 days after the screening and anthropometric outcomes at the corrected age of 24 months old. Infants with any hormonal replacement, severe brain injury, congenital anomaly, or cerebral palsy were excluded. In total, 290 (86.8%) VPIs were included for analysis. In the 28 days after thyroid function screening, the TT4 concentration was found to have a significant association with positive increments in body weight (mean increment: 25.7 g per 1 μg/dL; p < 0.001) and a positive body weight z-score (mean increment: 0.039 per 1 μg/dL; p = 0.037), determined by generalized estimating equation analysis. At the corrected age of 24 months old, a higher postnatal TT4 concentration was associated with a lower body mass index (mean coefficient: −0.136; 95% CI: −0.231 to −0.041, p = 0.005) and lower body mass index z-score (mean coefficient: −0.097; 95% CI: −0.170 to −0.024, p = 0.009). Infants with a TT4 concentration > 6.4 ug/dL had significantly lower odds of overweight status (odds ratio: 0.365; 95% CI: 0.177 to 0.754, p = 0.006). We conclude that the postnatal TT4 concentration is associated with a positive increment in body weight in the short term. At the same time, the postnatal TT4 concentration is associated with lower odds of overweight status after long-term follow-up.