bluuebunny/crossref_metadata_2025 huggingface dataset:
Decreased Protein C Pathway Activity in COVID-19 Compared to Non-COVID Sepsis: An Observational and Comparative Cohort Study
Authors: Rühl Heiko , Bode Christian , Becher Tobias , Eckert Sebastian , Mohsen Ghaith , McRae Hannah L. , Müller Jens , Reda Sara , Loßnitzer Dirk , Oldenburg Johannes , Putensen Christian , Pötzsch Bernd
Published: September 2024

Sepsis-associated coagulopathy increases risk of mortality. Impairment of the anticoagulant protein C (PC) pathway may contribute to the thrombotic phenotype in coronavirus disease 2019 (COVID-19) sepsis. This study assessed the functionality of this pathway in COVID-19 and non-COVID sepsis by measuring its key enzymes, thrombin and activated PC (APC). The study population included 30 patients with COVID-19, 47 patients with non-COVID sepsis, and 40 healthy controls. In healthy controls, coagulation activation and subsequent APC formation was induced by 15 µg/kg recombinant activated factor VII one hour before blood sampling. APC and thrombin in plasma were measured using oligonucleotide-based enzyme capture assays. The indirect thrombin markers prothrombin-fragment 1+2 (F1+2) and thrombin-antithrombin complex (TAT) were also measured. Compared with stimulated healthy controls, median thrombin, F1+2, and TAT levels were higher in patients with COVID-19 (up to 6-fold, p < 2 × 10−6) and non-COVID sepsis (up to 4.7-fold, p < 0.010). APC levels were 2.4-fold higher in patients with COVID-19 (7.44 pmol/L, p = 0.011) and 3.4-fold higher in non-COVID sepsis patients (10.45 pmol/L, p = 2 × 10−4) than in controls (3.08 pmol/L). Thrombin markers and APC showed correlation in both COVID-19 (r = 0.364–0.661) and non-COVID sepsis patients (r = 0.535–0.711). After adjustment for PC levels, median APC/thrombin, APC/F1+2, and APC/TAT ratios were 2-fold (p = 0.036), 6-fold (p = 3 × 10−7) and 3-fold (p = 8 × 10−4) lower in the COVID-19 group than in the non-COVID sepsis group, and the latter two were also lower in the COVID-19 group than in stimulated healthy controls. In conclusion, it was found that a comparatively lower anticoagulant APC response in COVID-19 patients as compared to non-COVID sepsis patients, potentially linked to endothelial dysfunction, contributes to the prothrombotic phenotype of COVID-19 sepsis.
Coronary Artery Aneurysm or Ectasia as a Form of Coronary Artery Remodeling: Etiology, Pathogenesis, Diagnostics, Complications, and Treatment
Authors: Woźniak Patrycja , Iwańczyk Sylwia , Błaszyk Maciej , Stępień Konrad , Lesiak Maciej , Mularek-Kubzdela Tatiana , Araszkiewicz Aleksander
Published: September 2024

Coronary artery aneurysm or ectasia (CAAE) is a term that includes both coronary artery ectasia (CAE) and coronary artery aneurysm (CAA), despite distinct phenotypes and definitions. This anomaly can be found in 0.15–5.3% of coronary angiography. CAE is a diffuse dilatation of the coronary artery at least 1.5 times wider than the diameter of the normal coronary artery in a patient with a length of over 20 mm or greater than one-third of the vessel. CAE can be further subdivided into diffuse and focal dilations by the number and the length of the dilated vessels. Histologically, it presents with extensive destruction of musculoelastic elements, marked degradation of collagen and elastic fibers, and disruption of the elastic lamina. Conversely, CAA is a focal lesion manifesting as focal dilatation, which can be fusiform (if the longitudinal diameter is greater than the transverse) or saccular (if the longitudinal diameter is smaller than the transverse). Giant CAA is defined as a 4-fold enlargement of the vessel diameter and is observed in only 0.02% of patients after coronary. An aneurysmal lesion can be either single or multiple. It can be either a congenital or acquired phenomenon. The pathophysiological mechanisms responsible for the formation of CAAE are not well understood. Atherosclerosis is the most common etiology of CAAE in adults, while Kawasaki disease is the most common in children. Other etiological factors include systemic connective tissue diseases, infectious diseases, vasculitis, congenital anomalies, genetic factors, and idiopathic CAA. Invasive assessment of CAAE is based on coronary angiography. Coronary computed tomography (CT) is a noninvasive method that enables accurate evaluation of aneurysm size and location. The most common complications are coronary spasm, local thrombosis, distal embolization, coronary artery rupture, and compression of adjacent structures by giant coronary aneurysms. The approach to each patient with CAAE should depend on the severity of symptoms, anatomical structure, size, and location of the aneurysm. Treatment methods should be carefully considered to avoid possible complications of CAAE. Simultaneously, we should not unnecessarily expose the patient to the risk of intervention or surgical treatment. Patients can be offered conservative or invasive treatment. However, there are still numerous controversies and ambiguities regarding the etiology, prognosis, and treatment of patients with coronary artery aneurysms. This study summarizes the current knowledge about this disease’s etiology, pathogenesis, and management.
Metabolic-Associated Fatty Liver Disease and Cognitive Performance in Type 2 Diabetes: Basal Data from the Phytate, Neurodegeneration and Diabetes (PHYND) Study
Authors: Pujol Antelm , Sanchis Pilar , Tamayo María I. , Godoy Samantha , Calvó Paula , Olmos Asier , Andrés Pilar , Speranskaya Aleksandra , Espino Ana , Estremera Ana , Rigo Elena , Amengual Guillermo J. , Rodríguez Manuel , Ribes José Luis , Gomila Isabel , Grases Félix , González-Freire Marta , Masmiquel Lluís
Published: September 2024

The effect of liver fibrosis on mild cognitive impairment (MCI) and dementia risk in type 2 diabetes mellitus (T2DM) patients is unclear. Therefore, we performed a prospective cross-sectional study on 219 patients with T2DM and older than 60 years to evaluate the association between liver fibrosis, liver steatosis, and cognitive impairment. The Montreal Cognitive Assessment (MoCA) was used to screen for MCI or dementia. Liver fibrosis was estimated using the non-invasive Fibrosis-4 (FIB-4) score, and liver steatosis was assessed with the hepatic steatosis index. The mean age was 71 ± 6 years, 47% were women and according to MoCA cut-off values, 53.88% had MCI and 16.43% had dementia. A moderate or high risk of advanced fibrosis was significantly higher in patients with MCI or dementia compared to those with normal cognition (p < 0.001). After adjusting for confounders, a FIB-4 score greater than 1.54 was associated with MCI or dementia (p = 0.039). Multivariate analysis identified age over 70.5 years, antiplatelet medication use, and a FIB-4 score above 1.54 as the most relevant risk factors. Liver fibrosis, but not liver steatosis, is associated with MCI or dementia in older T2DM patients, suggesting that FIB-4 score might be a simple biomarker for the detection of cognitive impairment.
Experimental Investigation on the Acoustic Insulation Properties of Filled Paper Honeycomb-Core Wallboards
Authors: Song Yiheng , Yang Haixia , Zhu Nanxing , Chen Jinxiang
Published: September 2024

Honeycomb plates, due to their multi-cavity structure, exhibit excellent mechanical properties and sound insulation. Previous studies have demonstrated that altering the cell size and arrangement of honeycomb structures impacts their acoustic performance. Based on these findings, this study developed a wallboard structure with enhanced sound insulation by filling the cavities with paper fiber/cement facesheets and designing a stacked core structure. Through the reverberation chamber–anechoic chamber sound insulation experiment under 100–6300 Hz excitation and conducting orthogonal experiments from three dimensions, it was found that: (1) Compared to no filling, the filling with straw and glazed hollow bead can increase the sound transmission loss (STL) by more than 50% in the frequency bandwidth above 2000 Hz. This indicates that both types of fillings can significantly enhance the sound insulation performance of the honeycomb structure without a significant increase in economic costs. (2) The increase in paper fiber/cement facesheets improves the STL across the entire experimental bandwidth, with a maximum improvement exceeding 70%. This structural design not only offers superior sound insulation performance but also better suits practical engineering applications. (3) Increasing the number of core stacking units (from one to three), taking straw-filled paper honeycomb-core wallboards as an example, effectively increased the STL bandwidth. (4) This test enriches the application of honeycomb plates in sound insulation. Introducing fiber paper fiber/cement facesheets and eco-friendly, low-cost straw improves sound insulation and enhances the strength of honeycomb, making them more suitable for construction, particularly as non-load-bearing structures.
Fiber Showdown: A Comparative Analysis of Glass vs. Polypropylene Fibers in Hot-Mix Asphalt Fracture Resistance
Authors: Akram Hesham , Hozayen Hozayen A. , Abdelfatah Akmal , Khodary Farag
Published: September 2024

Cracks in asphalt mixtures compromise the structural integrity of roads, increase maintenance costs, and shorten pavement lifespan. These cracks allow for water infiltration, accelerating pavement deterioration and jeopardizing vehicle safety. This research aims to evaluate the impact of synthetic fibers, specifically glass fiber (GF) and polypropylene fiber (PPF), on the crack resistance of Hot-Mix Asphalt (HMA). An optimal asphalt binder content of 5% was used in all sample designs. Using the dry mixing technique, GFs and PPFs were incorporated into the HMA at dosages of 0.50%, 1.00%, and 1.50% by weight of the aggregate. The effects of these fibers on the mechanical fracture properties of the HMA were assessed using Semi-Circular Bending (SCB), Indirect Tensile Asphalt Cracking Tests (IDEAL-CTs), and Three-Point Bending (3-PB) tests. This study focused on fracture parameters such as fracture work, peak load, fracture energy, and crack indices, including the Flexibility Index (FI) and Crack Resistance Index (CRI). The results from the SCB and IDEAL-CT tests showed that increasing GF content from 0.5% to 1.5% significantly enhances the flexibility and crack resistance of HMA, with FI, CRI, and CT Index values increasing by 247.5%, 55%, and 101.35%, respectively. Conversely, increasing PPF content increases the mixture’s stiffness and reduces its crack resistance. The PP-1 mixture exhibited higher FI and CT Index values, with increases of 31.1% and 10%, respectively, compared to the PP-0.5 mixture, based on SCB and IDEAL-CT test results. The SCB, IDEAL-CT, and 3-PB test results concluded that fibers significantly influence the fracture properties of bituminous mixtures, with a 1% reinforcement dosage of both PPFs and GFs being optimal for enhancing performance across various applications.
Improved State-Space Approach Based on Lumped Mass Matrix for Transient Analysis of Large-Scale Locally Nonlinear Structures
Authors: Sun Baoyin , Xuan Jiaheng , Gao Long , Wang Kai , Ou Jinping
Published: September 2024

Due to the assumption of acceleration variation in traditional step-by-step integration methods such as Newmark, sufficiently small time steps are required to ensure numerical stability and accuracy in dynamic systems. In contrast, the state-space approach, based on piecewise interpolation of discrete load functions, does not rely on predetermined acceleration assumptions and has demonstrated high efficiency in terms of stability and accuracy. The original state-space method requires the calculation of the inverse of the structural mass in the transition matrix. However, when a lumped mass matrix is used, this computation renders the entire mass matrix singular, resulting in an invalid solution expression. To address this issue, this study proposes an improved state-space approach for the transient analysis of large-scale structural systems with local nonlinearities. In this approach, a nonlinear force corrector is introduced as an external force term applied to the linear elastic system to account for the nonlinear behavior of locally yielding components. Consequently, the original nonlinear dynamic system can be transformed into an equivalent linear elastic transient system. Furthermore, based on the lumped mass matrix, a first-order ordinary differential state-space equation for such an equivalent linear elastic transient system is derived. Simulation results from three transient system examples show that the state-space approach outperforms the Newmark method in terms of accuracy and stability for dynamic systems characterized by high frequency and low damping. The prediction results show that the state-space approach appears to be insignificantly affected by the choice of the consistent or lumped mass matrix. The numerical results show that the root-mean-square errors between the consistent and lumped matrices in the top displacement time histories of a 15-storey plane frame under various seismic intensities are all less than 1%, and in the base reaction time histories responses the discrepancies are only about 0.5%, indicating that the use of lumped mass matrices is quite reliable. When many nodes or degrees of freedom have no assigned mass, the dimensionality of the state-space equation can be significantly reduced using the lumped mass approach. Therefore, the simulation of large-scale systems can be simplified by employing the improved state-space approach with lumped mass matrices, yielding results nearly identical to those obtained using traditional methods. In conclusion, the improved state-space approach has great potential for the simulation of transient behavior in large-scale systems with local nonlinearities.
An Investigation into the Impact of Time-Varying Non-Conservative Loads on the Seismic Stability of Concrete-Filled Steel-Tube Arch Bridges
Authors: Han Xu , Han Bing , He Yikuan , Li Pengfei , Xie Huibing
Published: September 2024

When the arch rib of the mid-bearing through and lower-bearing through arch bridges undergoes out-of-plane deformation, it is usually subject to the resilience force provided by the flexible hanger, which is known as the “non-conservative force effect” of the suspender. In contrast to the static condition, in the dynamic scenario, the time-varying non-conservative force exerted by the flexible suspender becomes more complex due to dynamic changes in external load. Moreover, the difference in fundamental frequency and vibration period between the bridge system and arch rib may influence the stress distribution within the arch rib during ground motion. This paper investigates the impact of time-varying non-conservative forces on the dynamic stability of arch ribs in concrete-filled steel tube (CFST) bridges under seismic loads. Specifically, it examines the influence of different seismic waveforms, frequency disparities between bridge slabs and arch ribs, and suspender stiffness on the non-conservative effect. The results reveal significant disparities in the impact of non-conservative forces exerted by the suspender during seismic events with identical intensity but varying frequency characteristics. The influence of non-conservative forces on the dynamic stability of bridges escalates as deck stiffness increases, while it remains relatively unaffected by changes in suspender stiffness.
Knowledge Mobility and the Emergence of Contemporary Iraqi Architecture (1936–1958)
Authors: Abdullah Sakar Yousif , Al-Qaisi Sahar Basil
Published: September 2024

Planned by the British in the aftermath of World War I, the new state of Iraq—ruled by the Hashemite kingdom (1921–1958) under British mandate—emerged on the land of Mesopotamia and inherited its enormous cultural and architectural legacy. Colonial discourse was adopted by the British during the Hashemite reign to impose Western culture and hegemony. This paper reviews the impact of this colonial discourse in terms of Western architectural knowledge mobility on shaping Iraqi contemporary architecture in this epoch. The paper traces the education of nine notable early Iraqi architects with Western architectural academic backgrounds and studies 13 of their public buildings executed in 1936–1958, to reveal the stance of those architects toward this discourse and how their buildings connected to the legacy of Iraqi architecture. Findings rest on a style-coverage of the main local architectural legacy and Western architectural façade’s characteristics to detect and examine the nature and intensity of the transformations that the façades of these buildings exhibit compared to local traditions. Findings show that knowledge mobility helped develop certain types of architects’ responses toward local architectural traditions and colonial discourse that evolved through time during the study target epoch.
Physicochemical Analysis of Historical Ordu Taşbaşı Church Mortars and Recommendations for Restoration
Authors: Sarıalioğlu Ali , Karaca Zeki , Türkeli Erdem
Published: September 2024

Throughout history, the architecture of worship structures has been shaped based on different cultures and belief systems during the Roman, Seljuk, Anatolian Principalities, and Ottoman periods. Additionally, it is understood that the sociocultural and ritual structure in which the worship place is built plays a significant role in church architecture. In province of Ordu, rich in historical and cultural heritage, historical structures outside the city center have not been well preserved. In recent years, neglected historical structures have been restored through various methods with public investments, aiming to reintegrate them into urban life. Through chemical and mineralogical (by microscopy) examinations aimed at determining the types of historical structural materials used for this purpose, the preservation of historical structures in Ordu province and their transfer to future generations is targeted. Church structures, holding a distinct significance in the region’s history, exhibit various characteristics in terms of location, climate, and sociocultural and ritual aspects in the Black Sea region. In this regard, the restoration of the historical Taşbaşı Church in the Altınordu district of Ordu province has been carried out considering scientific techniques and methods, serving as a guide for similar studies in the region in terms of laboratory analysis, studies, planning, project development, and implementation stages.
Reverberation Time in Traditional Courtyard Yue Opera Theatres
Authors: Zhang Honghu , Wang Yuyang , Mao Wei
Published: September 2024

The development of traditional Chinese theatres is closely related to the development of traditional Chinese opera. The acoustic quality of the theatre plays a crucial role in the performance effect of Chinese opera. As one of the five major traditional Chinese opera genres, Yue opera has a significant number of existing traditional theatres in the Shaoxing area. This study conducted on-site measurements of the reverberation time in traditional courtyard Yue opera theatres. The results indicate that the mid-frequency EDT values in the main viewing areas range from 0.6 to 0.7 s, and T30 is around 0.7 s. Furthermore, aiming to investigate the optimal reverberation time for Yue opera performance spaces and the factors influencing preferences, subjective experiments using auralization technology and a paired comparison method were conducted. The results show that the optimal reverberation time for Yue opera performance spaces is around 0.8 s. There was no difference in the optimal reverberation time between the ordinary group and the experienced group, but the ordinary group tended to show a higher preference for shorter reverberation times. Compared to singing clips, recitation clips obtained higher preference scores for short reverberation times, indicating that audiences require higher clarity when listening to recitations.
Research on the Pile–Soil Interaction Mechanism of Micropile Groups in Transparent Soil Model Experiments
Authors: Wang Ziyi , Xu Xinyu , Li Ziqi
Published: September 2024

Micropile groups (MPGs) are typical landslide resistant structures. To investigate the effects of these two factors on the micropile–soil interaction mechanism, seven sets of transparent soil model experiments were conducted on miniature cluster piles. The soil was scanned and photographed, and the particle image velocimetry (PIV) technique was used to obtain the deformation characteristics of the pile and soil during lateral loading. The spatial distribution information of the soil behind the pile was obtained by a 3D reconstruction program. The results showed that a sufficient roughness of the pile surface was a necessary condition for the formation of a soil arch. If the surface of the pile was smooth, stable arch foundation formation was difficult. When the roughness of the pile surface increases, the soil arch range behind the pile and the load-sharing ratio of the pile and soil will increase. After the roughness reaches a certain level, the above indicators hardly change. Pile spacing within the range of 5–7 d (pile diameters) was suitable. The support effect was poor when the pile spacing was too large. No stable soil arch can be formed, and the soil slips out from between the piles.
Highly Efficient Production of Furfural from Corncob by Barley Hull Biochar-Based Solid Acid in Cyclopentyl Methyl Ether–Water System
Authors: Fan Bo , Kong Linghui , He Yucai
Published: September 2024

Furfural, an important biobased compound, can be synthesized through the chemocatalytic conversion of D-xylose and hemicelluloses from lignocellulose. It has widespread applications in the production of valuable furans, additives, resins, rubbers, synthetic fibers, polymers, plastics, biofuels, and pharmaceuticals. By using barley hulls (BHs) as biobased support, a heterogeneous biochar Sn-NUS-BH catalyst was created to transform corncob into furfural in cyclopentyl methyl ether–H2O. Sn-NUS-BH had a fibrous structure with voids, a large comparative area, and a large pore volume, which resulted in more catalytic active sites. Through the characterization of the physical and chemical properties of Sn-NUS-BH, it was observed that the Sn-NUS-BH had tin dioxide (Lewis acid sites) and a sulfonic acid group (Brønsted acid sites). This chemocatalyst had good thermostability. At 170 °C for 20 min, Sn-NUS-BH (3.6 wt%) was applied to transform 75 g/L of corncob with ZnCl2 (50 mM) to generate furfural (80.5% yield) in cyclopentyl methyl ether–H2O (2:1, v/v). This sustainable catalytic process shows great promise in the transformation of lignocellulose to furfural using biochar-based chemical catalysts.
1,25-Dihydroxyvitamin D Enhances the Regenerative Function of Lgr5+ Intestinal Stem Cells In Vitro and In Vivo
Authors: Shaikh Nisar Ali , Liu Chenfan , Yin Yue , Baylink David J. , Tang Xiaolei
Published: September 2024

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder in the intestines without a cure. Current therapies suppress inflammation to prevent further intestinal damage. However, healing already damaged intestinal epithelia is still an unmet medical need. Under physiological conditions, Lgr5+ intestinal stem cells (ISCs) in the intestinal crypts replenish the epithelia every 3–5 days. Therefore, understanding the regulation of Lgr5+ ISCs is essential. Previous data suggest vitamin D signaling is essential to maintain normal Lgr5+ ISC function in vivo. Our recent data indicate that to execute its functions in the intestines optimally, 1,25(OH)2D requires high concentrations that, if present systemically, can cause hypercalcemia (i.e., blood calcium levels significantly higher than physiological levels), leading to severe consequences. Using 5-bromo-2′-deoxyuridine (BrdU) to label the actively proliferating ISCs, our previous data suggested that de novo synthesized locally high 1,25(OH)2D concentrations effectively enhanced the migration and differentiation of ISCs without causing hypercalcemia. However, although sparse in the crypts, other proliferating cells other than Lgr5+ ISCs could also be labeled with BrdU. This current study used high-purity Lgr5+ ISC lines and a mouse strain, in which Lgr5+ ISCs and their progeny could be specifically tracked, to investigate the effects of de novo synthesized locally high 1,25(OH)2D concentrations on Lgr5+ ISC function. Our data showed that 1,25(OH)2D at concentrations significantly higher than physiological levels augmented Lgr5+ ISC differentiation in vitro. In vivo, de novo synthesized locally high 1,25(OH)2D concentrations significantly elevated local 1α-hydroxylase expression, robustly suppressed experimental colitis, and promoted Lgr5+ ISC differentiation. For the first time, this study definitively demonstrated 1,25(OH)2D’s role in Lgr5+ ISCs, underpinning 1,25(OH)2D’s promise in IBD therapy.
The Multifaceted Role of Endothelial Sirt1 in Vascular Aging: An Update
Authors: Campagna Roberto , Mazzanti Laura , Pompei Veronica , Alia Sonila , Vignini Arianna , Emanuelli Monica
Published: September 2024

NAD+-dependent deacetylase sirtuin-1 (Sirt1) belongs to the sirtuins family, known to be longevity regulators, and exerts a key role in the prevention of vascular aging. By aging, the expression levels of Sirt1 decline with a severe impact on vascular function, such as the rise of endothelial dysfunction, which in turn promotes the development of cardiovascular diseases. In this context, the impact of Sirt1 activity in preventing endothelial senescence is particularly important. Given the key role of Sirt1 in counteracting endothelial senescence, great efforts have been made to deepen the knowledge about the intricate cross-talks and interactions of Sirt1 with other molecules, in order to set up possible strategies to boost Sirt1 activity to prevent or treat vascular aging. The aim of this review is to provide a proper background on the regulation and function of Sirt1 in the vascular endothelium and to discuss the recent advances regarding the therapeutic strategies of targeting Sirt1 to counteract vascular aging.
Curcumin Inhibits TORC1 and Prolongs the Lifespan of Cells with Mitochondrial Dysfunction
Authors: Naaz Arshia , Zhang Yizhong , Faidzinn Nashrul Afiq , Yogasundaram Sonia , Dorajoo Rajkumar , Alfatah Mohammad
Published: September 2024

Aging is an inevitable biological process that contributes to the onset of age-related diseases, often as a result of mitochondrial dysfunction. Understanding the mechanisms behind aging is crucial for developing therapeutic interventions. This study investigates the effects of curcumin on postmitotic cellular lifespan (PoMiCL) during chronological aging in yeast, a widely used model for human postmitotic cellular aging. Our findings reveal that curcumin significantly prolongs the PoMiCL of wildtype yeast cells, with the most pronounced effects observed at lower concentrations, indicating a hormetic response. Importantly, curcumin also extends the lifespan of postmitotic cells with mitochondrial deficiencies, although the hormetic effect is absent in these defective cells. Mechanistically, curcumin inhibits TORC1 activity, enhances ATP levels, and induces oxidative stress. These results suggest that curcumin has the potential to modulate aging and offer therapeutic insights into age-related diseases, highlighting the importance of context in its effects.
Resolution of Glycerol, Ethanol and Methanol Employing a Voltammetric Electronic Tongue
Authors: de Oliveira João Pedro Jenson , Bonet-San-Emeterio Marta , de Sá Acelino Cardoso , Cetó Xavier , Paim Leonardo Lataro , del Valle Manel
Published: September 2024

This paper reports the use of nanoparticles (NPs)-modified voltammetric sensors for the rapid determination of glycerol in the presence of ethanol and methanol, which are used in the transesterification reaction of biodiesel production. Two different modified electrodes have been prepared to form the electronic tongue (ET): copper hexacyanoferrate NPs obtained by chemical synthesis and mixed into graphite/epoxy (GEC) electrode, and nickel hydroxide NPs electrodeposited in reduced graphene oxide onto a GEC electrode. The response characteristics of these electrodes were first evaluated by building the respective calibration against glycerol, ethanol, and methanol. The electrodes demonstrated good stability during their analytical characterization, while principal component analysis confirmed the differentiated response against the different alcohols. Finally, the quantification of mixtures of these substances was achieved by a genetic algorithm-artificial neural networks (GA-ANNs) model, showing satisfactory agreement between expected and obtained values.
Machine Learning-Assisted 3D Flexible Organic Transistor for High-Accuracy Metabolites Analysis and Other Clinical Applications
Authors: Liao Caizhi , Wu Huaxing , Occhipinti Luigi G.
Published: September 2024

The integration of advanced diagnostic technologies in healthcare is crucial for enhancing the accuracy and efficiency of disease detection and management. This paper presents an innovative approach combining machine learning-assisted 3D flexible fiber-based organic transistor (FOT) sensors for high-accuracy metabolite analysis and potential diagnostic applications. Machine learning algorithms further enhance the analytical capabilities of FOT sensors by effectively processing complex data, identifying patterns, and predicting diagnostic outcomes with 100% high accuracy. We explore the fabrication and operational mechanisms of these transistors, the role of machine learning in metabolite analysis, and their potential clinical applications by analyzing practical human blood samples for hypernatremia syndrome. This synergy not only improves diagnostic precision but also holds potential for the development of personalized diagnostics, tailoring treatments for individual metabolic profiles.
Long-Term Mandatory Homeschooling during COVID-19 Had Compounding Mental Health Effects on Parents and Children
Authors: Groff Lucretia V. M. , Elgendi Mariam M. , Stewart Sherry H. , Deacon Storm Hélène
Published: September 2024

Background/Objectives: Most studies have linked mandatory homeschooling during COVID-19 to mental health harm in parents and children, while a minority have found non-significant or beneficial effects. Past studies have not measured mandatory homeschooling continuously over an extended period; consequently, they could not capture compounding mental health effects, which may explain conflicting results. We asked whether children’s cumulative time spent homeschooled during COVID-19 school closure mandates caused compounding harm for parent and child mental health, and whether parent employment, child internet access and educational support from schools (live and pre-recorded online classes, home learning packs) impacted this relationship. We aimed to identify the families at greatest risk of mental health harm during mandatory homeschooling and the educational support that may have mitigated this risk. Methods: Couples completed retrospective, cross-sectional survey questionnaires assessing parent depression, anxiety and stress, child internalizing and externalizing symptoms, and the family’s homeschooling experience. Data were analyzed using mediation analysis total effects, ordinary least squares regression and simple slopes analysis. Results: Both parents and children experienced compounding mental health harm during mandatory homeschooling. Live online classes protected parents and children, while home learning packs protected children. Unexpectedly, reliable internet access and the employment of both parents placed children at greater risk. Conclusions: Findings suggest that long-term mandatory homeschooling during COVID-19 placed families at greater risk of mental health harm. To protect family mental health during homeschooling mandates, schools should provide children with evidence-based educational support.
Cardiorespiratory Fitness Is an Indicator of Arterial Stiffness and Aortic Blood Pressure in Healthy Adolescents
Authors: Kim Hwan , Collier Scott R. , Bonavolontà Valerio , Lassiter Austin , Wait Seaver , Meucci Marco
Published: September 2024

Background/Objectives: We aimed to investigate the influence of cardiorespiratory fitness (CRF) and body composition on arterial stiffness. Methods: Carotid-to-femoral pulse wave velocity (cfPWV) and aortic systolic (ASBP) and diastolic (ADBP) blood pressure were compared between upper and lower tertiles of oxygen consumption at the aerobic threshold (VO2AerT), peak oxygen consumption (VO2peak), percentage of fat mass (FM%), and body mass index (BMI) in sixty adolescents (30 males and 30 females, 14.9 ± 2.1 years old). A stepwise multivariable linear regression analysis was performed to investigate the independent associations between VO2AerT and VO2peak and cfPWV, and between BMI and FM% and cfPWV with adjustments for age, sex, ASBP, and ADBP. Results: cfPWV and ADBP were lower in the second and third VO2AerT tertiles compared to the first tertile (cfPWV, 4.7 ± 0.5 and 4.7 ± 0.5 vs. 5.3 ± 0.8 m/s, p < 0.01; ADBP, 62 ± 7 and 62 ± 7 vs. 70 ± 8 mmHg, p < 0.01). ASBP was lower in the third VO2AerT tertile compared to the first tertile (94 ± 7 vs. 101 ± 12 mmHg, p = 0.05). ADBP was lower in the second VO2peak tertile compared to the first tertile (62 ± 7 vs. 68 ± 9 mmHg, p = 0.03). ASBP was lower in the first and second BMI tertiles compared to the third tertile (95 ± 8 and 95 ± 7 vs. 102 ± 11 mmHg, p = 0.02). The eight-variable model significantly contributed to the variance of cfPWV (F(8, 51) = 7.450, p < 0.01), accounting for 47% of the variance. Individually, age (p < 0.05) and ADBP (p < 0.01) significantly predicted cfPWV. Conclusions: Submaximal indicators of CRF such as VO2AerT should be considered as a part of the risk stratification of cardiovascular disease in healthy adolescents.
Development of a Spatial Synoptic Classification Scheme for East Africa with a Focus on Kenya
Authors: Alaso Daniella C. , Senkbeil Jason C. , Sheridan Scott C.
Published: September 2024

Despite the wide range of applications of the Spatial Synoptic Classification (SSC), its expansion and utility in the tropics remains limited. This research utilized the fifth generation of European ReAnalysis (ERA5) data to develop an SSC scheme tailored for East Africa with a focus on Kenya. The SSC method classifies weather into seven types: Dry Polar (DP), Dry Moderate (DM), Dry Tropical (DT), Moist Polar (MP), Moist Moderate (MM), Moist Tropical (MT), and Transitional (TR). Frequency and trend analysis between 1959 and 2022 show that the MT and DM weather types are the dominant types in Kenya. The DM type is dominant in the December–February (DJF) dry season while the MT type is common from April to September. We find statistically significant decreasing trends in the DM, MP, and MM weather types and increasing trends in the DT and MT weather types. The results suggest that, generally, the number of days with cool and moderate conditions in Kenya is decreasing, while the number of days with warmer conditions is increasing. This research indicates the potential for the SSC to be utilized in different applications in East Africa including investigating heat vulnerability, as increasing temperatures could be a significant risk factor to human health.
Flexible and High-Strength Porous Graphene/Polyurea Composite Film for Multifunctional Applications
Authors: Cui Xu , Guo Mengying , Han Sensen , Li Shuangshan , Yu Yin , Zhang Yanxi , Meng Qingshi
Published: September 2024

Porous composites possess distinctive structural features and performance advantages, making them promising for applications in various domains such as sensing, energy storage, and acoustics. A simple, efficient, and environmentally friendly method was employed to prepare porous polyurea materials, which were then modified with graphene nanosheets. The resulting graphene/polyurea porous composites demonstrated enhanced mechanical properties, with a 35.04% increase in tensile strength at a graphene content of 5 wt%. These composites exhibited exceptional multifunctionality, achieving a specific capacitance of 35.74 F/g when used as capacitor electrodes. Additionally, they displayed high sensitivity to resistance and capacitance changes under various mechanical loads, such as tensile, torsional, and bending stresses, with a resistance change rate of 57.72% under 180-degree torsion, highlighting their potential as resistive and capacitive sensors. Compared to traditional materials, the multifunctional composites maintained a resistance change rate below 40% and a capacitance retention rate above 95.07% after 10,000 cycles, underscoring their durability and reliability. Moreover, the developed graphene/polyurea porous composites exhibited good corrosion resistance and an impressive sound absorption rate of 30.68% for high-decibel noise, reducing environmental limitations for their applications. These properties position the composite as a durable, high-sensitivity, multifunctional material with significant potential in sensing, energy storage, and noise reduction applications.
Optimization of Laser Cladding Parameters for High-Entropy Alloy-Reinforced 316L Stainless-Steel via Grey Relational Analysis
Authors: Gao Senao , Fu Qiang , Li Mengzhao , Huang Long , Liu Nian , Cui Chang , Yang Bing , Zhang Guodong
Published: September 2024

Laser cladding technology serves as a pivotal technique in industrial production, especially in the realms of additive manufacturing, surface enhancement, coating preparation, and the repair of part surfaces. This study investigates the influence of metal powder composition and processing parameters on laser cladding coatings utilizing the Taguchi orthogonal experimental design method. To optimize the laser cladding parameters, multi-response grey relational analysis (GRA) was employed, aiming to improve both the microhardness and the overall quality of the coatings. The optimal parameter combinations identified through GRA were subsequently validated through experimental tests. The results reveal that the microhardness and quality of the coatings are substantially influenced by several critical factors, including the powder feed rate, laser power, high-entropy alloy (HEA) addition rate, scanning speed, and substrate tilt angle. Specifically, the powder feed rate exerts the most significant effect on the microhardness, dilution rate, and average contact angle. In contrast, laser power primarily impacts the mean contact angle difference. The HEA addition rate notably affects the mean contact angle difference, while the scanning speed affects the microhardness and the substrate tilt angle influences the average contact angle. The results of the validation experiment showed a deviation of only 0.95% from the predicted values, underscoring the efficacy of the grey relational analysis (GRA) in optimizing the laser cladding process parameters. The methodology presented in this paper can be applied to determine the ideal processing parameters for multi-response laser cladding processes, encompassing applications such as surface peening and surface repair.
Influence of the Dispersion of Carbon Nanotubes on the Electrical Conductivity, Adhesion Strength, and Corrosion Resistance of Waterborne Polyurethane Composites
Authors: Wang Fangfang , Liu Xiangrong , Cao Bin , Wang Xiaobao , Dong Kangjun
Published: September 2024

Due to the presence of many flammable substances in the working environments of the petrochemical industry, anticorrosive conductive coatings need to be used on metal equipment to avoid safety accidents like fires. However, existing conductive solvent-based coatings are volatile when exposed to flammable and toxic organic solvents. Thus, in this work, a series of eco-friendly anticorrosive waterborne polyurethane (WPU) composites with multi-walled carbon nanotubes (MWCNTs) were prepared via a low-cost and practical process; the dispersion of MWCNTs was revealed when present in different amounts, and the mechanism behind the conduction of WPU composites was determined. We concluded that low amounts of MWCNTs were well dispersed, generating a conductive network, and the WPU composite was not entirely covered by the MWCNT particles, so the electrical conductivity in certain parts of the coating was good. When the content of MWCNTs was excessive, some stretched MWCNTs dispersed to the top of the composite and many MWCNTs agglomerated at the bottom. Additionally, when the content of MWCNTs was increased, the electrical conductivity, corrosion resistance, and adhesion strength of the WPU composite decreased. Our results could provide a theoretical foundation for the preparation of anticorrosive conductive waterborne composites for protecting equipment in the petrochemical industry.
Photocatalytic Degradation of Sulfamethoxazole by Cd/Er-Doped Bi2MoO6
Authors: Yang Nengxun , Niu Yixuan , Zhang Bohang , Zhang Fuchun
Published: September 2024

Bi2MoO6 (BMO) is a typical bismuth-based semiconductor material, and its unique Aurivillius structure provides a broad space for electron delocalization. In this study, a new type of bismuth molybdate Cd/Er-BMO photocatalytic material was prepared by co-doping Er3+ and Cd2+, and the performance of the photocatalytic degradation of sulfamethoxazole (SMZ) was systematically studied. The research results showed that the efficiency of SMZ degradation by Cd/Er-BMO was significantly improved after doping Er3+ and Cd2+ ions, reflecting the synergistic catalytic effect of Cd2+ and Er3+ co-doping. Cd/Er-BMO doped with 6% Cd had the highest degradation efficiency (93.89%) of SMZ under visible light irradiation. The material revealed excellent stability and reusability in repeated degradation experiments. In addition, 6% Cd/Er-BMO had a smaller particle size and a larger specific surface area, which is conducive to improving the generation efficiency of its photogenerated electron-hole pairs and reducing the recombination rate, significantly enhancing the photocatalysis of the material. This study not only provides an effective photocatalyst for degrading environmental pollutants such as SMZ, but also provides an important scientific basis and new ideas for the future development of efficient and stable photocatalytic materials.
Impact of Calcium Chloride Addition on the Microstructural and Physicochemical Properties of Pea Protein Isolate-Based Films Plasticized with Glycerol and Sorbitol
Authors: Kowalczyk Dariusz , Kazimierczak Waldemar
Published: September 2024

Ca2+ can boost protein-protein interactions and, if present at an appropriate level, can potentially improve some physicochemical properties of protein-based gels and films. This study aimed to determine the effects of CaCl2 (0%–0.05% w/w) on the microstructural, optical, water affinity, and mechanical characteristics of glycerol (Gly)- and sorbitol (Sor)-plasticized pea protein isolate (PPI)-based films. CaCl2 caused darkening and a color shift of the films from yellow to yellow-green. Additionally, decreased light transmission, particularly in the UV range, acidification, and reduced moisture content were observed. CaCl2 decreased the water vapor permeability of the Gly plasticized film by an average of 20% with no effect on the Sor-plasticized film. All films were completely soluble in water. CaCl2 negatively impacted the mechanical integrity of the films, reducing the tensile strength of the Gly- and Sor-plasticized films by ~16% and 14%–37%, respectively. Further increases in CaCl2 content (0.1% and 0.2% w/w) led to concentration-dependent microvoids resulting from protein over-crosslinking and/or coagulation. In summary, the incorporation of CaCl2 into PPI-based films did not provide significant benefits and actually worsened key properties, such as transparency and mechanical strength. The type of plasticizer influenced how CaCl2 affected some properties of the PPI-based film.
In Situ Modulation of Oxygen Vacancy Concentration in Hf0.5Zr0.5O2−x Thin Films and the Mechanism of Its Impact on Ferroelectricity
Authors: Liu Shikai , Li Xingyu , Li Gang , Yan Shaoan , Zhu Yingfang , Wu Yujie , Jiang Qin , Zhan Yang , Tang Minghua
Published: September 2024

Oxygen vacancies play a crucial role in stabilizing the ferroelectric phase in hafnium (Hf) oxide-based thin films and in shaping the evolution of their ferroelectric properties. In this study, we directly manipulated the oxygen vacancy concentration in Hf0.5Zr0.5O2−x (HZO) ferroelectric thin films in situ using oxygen plasma treatment. We scrutinized the variations in the ferroelectric properties of HZO films across different oxygen vacancy concentrations by integrating the findings from ferroelectric performance tests. Additionally, we elucidated the mechanism underlying the influence of oxygen vacancies on the coercive field and polarization properties of HZO ferroelectric films through the first-principles density functional theory (DFT) calculations. Finally, to study the impact of oxygen vacancies on the practical application of HZO ferroelectric synaptic devices, leveraging the plasticity of the ferroelectric polarization, we constructed a multilayer perceptron (MLP) network. We simulated its recognition accuracy and convergence speed under different oxygen vacancy concentrations in the MNIST recognition task.
Optimization of Black Nickel Coatings’ Electrodeposit onto Steel
Authors: Santos Gabriel , Benzarti Zohra , Cavaleiro Diogo , Figueiredo Luís , Carvalho Sandra , Devesa Susana
Published: September 2024

Coatings can be created using various technologies and serve different roles, including protection, functionality, and decorative purposes. Among these technologies, electrodeposition has emerged as a low-cost, versatile, and straightforward process with remarkable scalability and manufacturability. Nickel, extensively studied in the context of electrodeposition, has many applications ranging from decorative to functional. The main objective of the present work is the electrodeposition of double-layer nickel coatings, consisting of a bright nickel pre-coating followed by a black nickel layer with enhanced properties, onto steel substrates. The influence of deposition parameters on colour, morphology, adhesion, roughness, and coefficient of friction was studied. The effects of cetyltrimethylammonium bromide (CTAB) and WS2 nanoparticles on the coatings’ properties and performance were also investigated. Additionally, the influence of the steel substrate’s pre-treatment, consisting of immersion in an HCl solution, prior to the electrodeposition, to etch the surface and activate it, was evaluated and optimized. The characterization of the pre-coating revealed a homogeneous surface with a medium superficial feature of 2.56 μm. Energy dispersive X-ray spectroscopy (EDS) results showed a high content of Ni, and X-ray diffraction (XRD) confirmed its crystallinity. In contrast, the black films’ characterization revealed their amorphous nature. The BN10 sample, which corresponds to a black nickel layer with a deposition time of 10 min, showed the best results for colour and roughness, presenting the lowest brightness (L*) value (closest to absolute black) and the most homogeneous roughness. EDS analysis confirmed the incorporation of WS2, but all samples with CTAB exhibited signs of corrosion and cracks, along with higher coefficient of friction (COF) values.