bluuebunny/crossref_metadata_2025 huggingface dataset:
Estratégias educacionais na comunicação em cuidados paliativos
Authors: Castilhos Valentina de , Vale Gustavo Fernando do , Cunha Leticia , Moreira Marcus , Souza Maria Jacqueline Nogueira de , Cobucci Ricardo
Published: October 2024

OBJETIVO: Identificar as estratégias utilizadas na educação médica para o desenvolvimento de habilidades de comunicação na vigência dos cuidados paliativos. MÉTODOS: Trata-se de uma revisão narrativa da literatura, com artigos selecionados nas plataformas PubMed e Scopus através dos Descritores em Ciências da Saúde (DeCS): Education, Medical; Health Communication, Integrative Palliative Care, associados com o operador booleano "AND". Após aplicada a estratégia de busca nas bases, os critérios de inclusão foram: artigos publicados nos últimos cinco anos, em inglês, português ou espanhol e que fossem disponíveis na íntegra, enquanto os de exclusão foram: protocolos, artigos pré-print, editoriais, relatos de experiência, estudos duplicados e os que não respondessem à pergunta de pesquisa. RESULTADOS: Foram incluídos 18 estudos, que indicaram as seguintes estratégias de ensino: capacitações, cursos, estágios, treinamentos intensivos e práticas em setores específicos para melhorar comunicação em cuidados paliativos. Além disso, indicaram haver dificuldades para realizar a comunicação de más notícias por parte dos médicos, sobretudo, nos cuidados paliativos, sendo recomendadas medidas para expandir o conhecimento e domínio dos profissionais. CONCLUSÕES: Cursos, treinamentos e práticas com supervisão podem melhorar a comunicação de más notícias e são estratégias de ensino com impactos positivos para profissionais envolvidos com cuidados paliativos.
Métodos contra hipotermia no recém-nascido pré-termo
Authors: Maia Gabriela Mayumi Ukei , Brito Yasmin Yngrid Mendes de , Mendes Gustavo Napoli , Vidal Mariana Pessoa , Pereira Letícia Maria Fernandes , Mendes Nathalia Napoli , Padilha Deborah de Melo Magalhães
Published: October 2024

OBJETIVO: O presente artigo teve como objetivo compilar os atuais métodos intervencionais contra hipotermia e discutir quais seriam os mais efetivos em recém-nascido pré-termo. MÉTODOS: Revisão de literatura de artigos selecionados em bases de dados eletrônicos (PubMed, PMC, BVS, ScienceDirect-Elsevier e Scopus), referente aos anos de 2018 a 2023. Foram excluídos os estudos indisponíveis e duplicados, e incluídos os estudos publicados em língua portuguesa e inglesa, que descreveram o conhecimento atual sobre intervenções hipotérmicas no recém-nascido pré-termo. RESULTADOS: Foram encontrados 73 artigos, dos quais 18 foram selecionados. Observou-se que as principais medidas utilizadas em recém-nascidos com hipotermia são contato pele a pele, uso de bandagens, gases aquecidos e umidificados, sacos “zip-lock”, polietileno, incubadora, sonda e sistema servo controlado, com variadas taxas de impacto sobre morbimortalidade. CONCLUSÃO: Recém-nascidos prematuros apresentam maior risco de complicações neonatais, especialmente devido a perda de calor. Métodos eficazes, como contato pele a pele, bandagens, sacos “zip-lock”, polietileno, incubadora e gases aquecidos e umedecidos, destacam-se na abordagem da hipotermia em recém-nascidos pré-termo. Uma análise crítica enfatiza a importância dessas intervenções como esforço contínuo para reduzir perdas térmicas e prevenir complicações.
Transtorno do Espectro Autista: uso da cannabis em pacientes pediátricos
Authors: Freire Luiz Eduardo Matoso , Gomes Giovana Montenegro Amorim , Fabrício Ingrid Letícia Torres , Souza Juliana Estanislau de , Bremner Lara Lais , Maia Lara Pacheco Barretto , Melo Renata Fonseca de Oliveira , Padilha Deborah de Melo Magalhães
Published: October 2024

OBJETIVO: Essa revisão visa avaliar criticamente a viabilidade terapêutica da cannabis medicinal em crianças com transtorno do espectro autista (TEA), contribuindo para tomada de decisão clínica com base em evidências. MÉTODOS: Revisão da literatura abrangendo estudos publicados entre 2019 e 2023 nas bases de dados PubMed, BVS e Google Acadêmico. Foram incluídos artigos que avaliaram o uso de cannabis em pacientes pediátricos diagnosticados com TEA. RESULTADOS: Os estudos atestam a capacidade da cannabis em reduzir tanto a quantidade quanto a intensidade dos sintomas típicos do TEA. Adicionalmente, os dados demonstraram uma melhoria nos domínios cognitivos, interação social e linguagem. Contudo, os autores relataram preocupações sobre os impactos da cannabis no desenvolvimento cerebral e seus principais efeitos adversos. CONCLUSÃO: Evidências sobre o potencial terapêutico seguro do canabidiol (CBD) para mitigar sintomas do TEA em crianças são uma realidade, mas estudos com maior certeza de evidência são necessários. O CBD apresenta-se como uma opção promissora, mas ensaios clínicos robustos precisam comprovar eficácia, segurança e apontar doses ideais.
Pembelajaran Berdiferensiasi dengan Model Problem Based Learning (PBL) dalam Mengembangkan Kemampuan Pemecahan Masalah Matematika Peserta Didik
Authors: Masrukhah Nurul , Zawawi Irwani , Huda Syaiful
Published: October 2024

Penelitian ini bertujuan untuk mendeskripsikan aktivitas peserta didik selama diterapkan Pembelajaran Berdiferensiasi dengan Model Problem Based Learning (PBL), dan mendeskripsikan kemampuan pemecahan masalah matematika peserta didik setelah diterapkan Pembelajaran Berdiferensiasi dengan Model PBL. Penelitian ini merupakan jenis penelitian deskriptif dengan pendekatan kuantitatif. Pelaksanaan penelitian berlangsung di SMP Muhammadiyah 4 Kebomas dengan subjek 15 peserta didik dari kelas VII A, yang dipilih melalui metode purposive. Teknik pengumpulan data menggunakan angket, observasi, dan tes. Metode analisis data yang dipilih meliputi analisis data gaya belajar, analisis data aktivitas peserta didik, serta analisis data kemampuan pemecahan masalah matematika peserta didik. Data yang diperoleh dianalisis menggunakan teknik analisis kuantitatif deskriptif.  Hasil penelitian ini adalah: (1) Aktivitas peserta didik selama diterapkan Pembelajaran Berdiferensiasi dengan Model Problem Based Learning (PBL) memperoleh hasil persentase sebesar 80,63%, termasuk dalam kriteria aktif. (2) Kemampuan pemecahan masalah matematika peserta didik setelah diterapkan Pembelajaran Berdiferensiasi dengan Model Problem Based Learning (PBL) berkembang, kemampuan pemecahan masalah matematika peserta didik dengan gaya belajar auditorial menurut pentahapan Newman pada tes awal kurang mampu dalam memproses permasalahan dan penulisan jawaban, sedangkan pada tes akhir peserta didik mampu dalam memproses permasalahan dan penulisan jawaban. Kemampuan pemecahan masalah matematika peserta didik dengan gaya belajar kinestetik menurut pentahapan Newman pada tes awal juga kurang mampu dalam memproses permasalahan dan penulisan jawaban, sedangkan pada tes akhir peserta didik mampu dalam memproses permasalahan dan penulisan jawaban. Kemampuan pemecahan masalah matematika peserta didik setelah diterapkan Pembelajaran Berdiferensiasi dengan Model Problem Based Learning (PBL) juga termasuk dalam kategori baik dengan nilai sebesar 83,33.
Tantangan dan Peluang Positivisme dan Kritisisme dalam Pendidikan Islam
Authors: Haikal Muhammad Fajrin , Alawiyah Risa , Parhan Muhamad
Published: October 2024

Penelitian ini bertujuan untuk menganalisis tantangan dan peluang yang dihadapi pendidikan Islam dalam menghadapi dua pendekatan filosofis utama, yaitu positivisme dan kritisisme, serta bagaimana integrasi keduanya dapat memperkuat sistem pendidikan Islam. Positivisme, dengan penekanannya pada pengetahuan empiris, seringkali mengabaikan aspek spiritual dan moral, yang menjadi tantangan utama bagi pendidikan Islam. Sebaliknya, kritisisme, terutama melalui pemikiran Kant, menekankan refleksi kritis terhadap ide-ide dan praktik, memberikan peluang untuk mengembangkan pemikiran yang lebih mendalam dan kritis. Penelitian ini menggunakan metode studi literatur (library research) dengan pendekatan kualitatif, mengumpulkan dan menganalisis data dari berbagai sumber literatur seperti buku, jurnal, dan artikel ilmiah terkait dengan pemikiran positivisme, kritisisme, dan pendidikan Islam. Hasil penelitian menunjukkan bahwa meskipun positivisme membawa tantangan dalam memisahkan agama dari ilmu pengetahuan, pendekatan ini dapat memperkuat metode pembelajaran ilmiah. Sementara itu, kritisisme membuka peluang untuk pengembangan pemikiran kritis dan menghadapi isu-isu kontemporer, sehingga keduanya dapat diintegrasikan dalam pendidikan Islam yang tetap mempertahankan nilai-nilai spiritual dan moral.
Pembuatan Soal Mandiri dan Diskusi Tertulis Sebagai Pendekatan Inklusif untuk Mahasiswa Generasi Z
Authors: Putri Arizkylia Yoka , Usman Aulia , Muhimmah Hitta Alfi , Hendratno Hendratno
Published: October 2024

Pembelajaran di perguruan tinggi idealnya melibatkan mahasiswa secara aktif, menjadikan mereka bukan hanya penerima materi, tetapi juga partisipan dalam pengembangan pemahaman dan analisis. Tujuan dari penelitian ini adalah mengeksplorasi efektivitas pembuatan soal mandiri dan diskusi tertulis dalam meningkatkan pemahaman mahasiswa. Metode penelitian yang digunakan adalah kualitatif dengan instrumen berupa kuesioner yang disebarkan kepada mahasiswa di lingkungan pendidikan tinggi. Kuesioner dirancang untuk mengukur persepsi mahasiswa terhadap kedua pendekatan tersebut, serta bagaimana penerapannya mempengaruhi pemahaman mereka terhadap materi pembelajaran. Teknik analisis data yang digunakan adalah deskriptif kualitatif, di mana hasil kuesioner dianalisis dengan mengelompokkan respons berdasarkan tema-tema yang muncul, seperti kenyamanan, keterlibatan, dan peningkatan pemahaman. Hasil penelitian menunjukkan bahwa mahasiswa yang dilibatkan dalam pembuatan soal mandiri memiliki pemahaman materi yang lebih mendalam, karena mereka dilatih untuk menyusun pertanyaan yang relevan dan menantang. Diskusi tertulis, terutama melalui platform digital, juga terbukti efektif dalam meningkatkan partisipasi mahasiswa yang cenderung pasif dalam diskusi lisan, sehingga memungkinkan terciptanya pembelajaran yang lebih inklusif. Dengan demikian, penelitian ini memberikan wawasan tentang pentingnya diversifikasi pendekatan pembelajaran di era digital untuk memenuhi kebutuhan mahasiswa generasi Z, yang cenderung lebih nyaman dengan pendekatan interaktif berbasis teknologi.
Clearing the Air to Address Pollution’s Cardiovascular Health Crisis
Authors: Miller Mark R. , Di Cesare Mariachiara , Rahimzadeh Shadi , Adeoye Marvellous , Perel Pablo , Taylor Sean , Shrikhande Shreya , Armstrong-Walenczak Kelcey , Shah Anoop S. V. , Berenstein César Damián , Vedanthan Rajesh , Achiri Elvis Ndikum , Mehta Sumi , Adeoye Abiodun Moshood , Piñeiro Daniel , Pinto Fausto J.
Published: October 2024

Air pollution is a critical global health issue that significantly impacts cardiovascular health. The air pollutant PM2.5 (particulate matter with a diameter of 2.5 micrometres or less) has been positioned as a leading environmental risk factor for morbidity and mortality, especially from cardiovascular diseases (CVDs).
Using data from the World Health Organization (WHO), Global Health Observatory, and the United Nations Environment Programme, we explored global trends in air pollution, with a focus on PM2.5 levels, the implications for cardiovascular health, and the policy measures aimed at reducing their impact.
Despite progress in reducing pollution levels in high-income countries, global trends show a limited annual reduction in PM2.5 concentration. The analysis highlights disparities between regions, with low- and middle-income countries bearing the brunt of air pollution-related CVDs. In 2019 alone, ambient air pollution was responsible for approximately 4.2 million deaths worldwide. Of these, 70% were caused by CVDs, with approximately 1.9 million deaths from ischemic heart disease and 900,000 deaths from stroke. Policy gaps remain a challenge, with many countries lacking adequate legally binding air quality standards.
We recommend the adoption of WHO air quality guidelines, enhanced monitoring of air pollution levels, and increased investment in interdisciplinary research to understand the full scope of air pollution’s effects on cardiovascular health. Addressing the global cardiovascular crisis linked to air pollution will require coordinated efforts from policymakers, healthcare systems, and global health organisations.
The effect of antenatal corticosteroid administration on umbilical artery Doppler velocimetry in pregnancies complicated with fetal growth restriction
Authors: Zamanova Sevda , Soysal Sunullah , Demir Merve
Published: October 2024

Objective: To examine the effect of antenatal corticosteroid administration on umbilical artery (UA) Doppler measurements in pregnancies complicated with fetal growth restriction (FGR).

Methods: This cross-sectional study was conducted with 149 pregnant women scheduled for antenatal corticosteroid therapy because of the possibility of preterm birth. UA Doppler measurements (PI, S/D ratio, RI) before antenatal corticosteroid administration and 24 and 48 hours after the last dose of corticosteroid administration were evaluated and compared with each other in pregnant groups complicated with FGR and uncomplicated with FGR.

Results: No statistically significant change was observed in UA Doppler parameters 24 and 48 hours after antenatal corticosteroid treatment in each group with and without FGR. While there was no significant difference between the precorticosteroid UA Doppler parameters (PI, S/D ratio, RI) of the two groups with and without FGR, the values of these parameters 24 hours after the last dose of treatment were statistically higher in the group complicated with FGR than in the uncomplicated group. However, no statistical difference was observed in UA Doppler parameters between the two groups 48 hours after the last dose of treatment.

Conclusion: Antenatal corticosteroid does not permanently affect UA Doppler parameters in the case of FGR. Close monitoring of the fetus for 72 hours after the first dose of antenatal corticosteroid may be helpful in pregnant women complicated by FGR.
Henoch-Schönlein Purpurali Çocukların Sistem Tutulumlarının Klinik Değerlendirilmesi
Authors: Borakay Dilek , Yiğit Özgül
Published: October 2024

Amaç: Henoch-Schönlein purpurası/İmmunoglobulin A vasküliti (HSP-IgAV) çocukluk döneminde en sık görülen vaskülit olup, etyolojisinde bazı enfeksiyonlar, ilaçlar, aşılar, genetik faktörler, AAA (Ailevi Akdeniz Ateşi) birlikteliği suçlanmaktadır. Ana özelliği palpabl cilt döküntüleri olup, eklem ve diğer birçok sistem etkilenmektedir. Başlangıçta gastrointestinal komplikasyonlar görülürken daha sonraki izleminde böbrek yetersizliğine kadar ilerleyebilen böbrek tutulumu önem kazanmaktadır. Çalışmamızda kliniğimizde izlenen HSP-IgAV tanılı çocukların demografik özelliklerini, sistem tutulumlarının dağılımını, etyolojik faktörleri ve AAA ile ilişkisini değerlendirmeyi amaçladık.
Materyal-Yöntem: Tanı kriteri olarak; palpabl purpura varlığında karın ağrısı, artrit/artralji, renal tutulum ve biyopside IgA depolanmasının gösterilmesi kriterinden birinin varlığı kabul edildi. Hastanemizde izlenen HSP-IgAV tanısı almış çocukların yaş, cins, vücut ağırlığı, boy, hastalığın ortaya çıkış tarihi-mevsimi, ilk semptom, fizik muayene ve laboratuvar bulguları kaydedildi.
Bulgular: Tanı kriterlerine uyan toplam 52 hasta çalışmaya alındı. Yaş ortalaması 7,5±3,6 (4-13) olup olguların %40’ı 7-10 yaş arasındaydı. Cinsiyete göre dağılımda hastaların 32’si (%61,5) erkek, 20’si (%38,4) kızdı ve erkek/kız oranı 1,6 bulundu. Yıl içindeki dağılımına bakıldığında ise en çok aralık ayında olmak üzere özellikle kış mevsiminde hasta sayısının yoğunlaştığı (%46,1; n=24) görüldü. İlk şikayet %80,7 (n=42) oranında döküntü idi. Diğerlerinde döküntünün ödem ve artralji sonrasında ortaya çıktığı belirtildi. Olguların 21’inde (%40,3) eklem tutulumu, 21’inde (%40,3) gastrointestinal tutulum, 21’inde (% 40,3) anormal idrar bulgusu, 13’ünde (%25) yüksek serum IgA, 10’unda (%19,2) AAA birlikteliği saptandı. Etyolojide viral tetkikler 6 olguda (%12) pozitifti. İzlemde 3 ay sonrasında 6 olguda (%11,5) idrar bulguları devam etmekteydi. Renal tutulum kızlarda ve 3-6 yaş arası ile 10 yaş üzerinde yoğunlaşmaktaydı.
Sonuç: HSP-IgAV olgularının değerlendirilmesinde prognoz renal tutuluma bağlı olduğundan hastalık sırasında ve özellikle uzun süreli izlemde idrar tetkiki yapılması, ayrıca ülkemizde sık görülen AAA birlikteliğinin de göz önünde bulundurulması gerekmektedir.
Apical Set-Back , A Simple Modification of Mustardé-Furnas Technique Otoplasty
Authors: Taga Senirli Rezarta
Published: October 2024

AMAÇ : Otoplasti ameliyatını yapmanın alternatif bir yöntemini anlatmak
YÖNTEM: 2015- 2021 yılları arasında yeni modifiye Mustardé- Furnas tekniği kullanarak opere edilen 43 primer hasta çalışmaya alınmıştır. Tüm hastalar en az 3 yıl süreyle takip edilmiştir
BULGULAR: Hastalarımızın sadece %2,5'inde yeniden operasyon gerekti. Geç postoperatif dönemde sütür atması (%12.5) ve enfeksiyon (%2.5) gibi bazı minör komplikasyonlarla karşılaşıldı. Hiçbir hastamızda majör komplikasyon gelişmedi.
SONUÇ: Otoplasti genç hastalarda en çok uygulanan estetik ameliyatlardan biridir. Klinik tecrübemize dayanarak modifiye tekniğimizin sonuçlarının standart tekniklere göre daha başarılı olduğunu gözlemledik.
From Request To Result: The Clinical Significance of EEG in a Tertiary Hospital in Turkey
Authors: Ağırcan Dilek , Bal Mehmet , Cekic Murat , Gesoğlu Demir Tülin , Göçmen Adalet , Ethemoğlu Özlem
Published: October 2024

Objective: This study aimed to assess the clinical and demographic profiles of patients undergoing electroencephalography (EEG) over one year, evaluate EEG's impact on patient management, and ascertain the appropriateness of EEG requests.
Methods: A retrospective analysis was conducted in the neurophysiology department at XXX University Faculty of Medicine over 12 months from October 2022 to October 2023. The study included the EEG request to the neurophysiology department; pediatrics and the cases that had artifacts or technical issues were excluded. Age, gender, imaging characteristics, EEG findings, and the reasons for EEG requests were recorded. The contribution of EEG to patient management was analyzed.
Results: The study included 1217 patients with a mean age of 34.4±16.5 years, ranging from 18 to 90 years. Of these, 656 were female and 561 male. A history of epilepsy was reported in 821 patients. Neurology outpatient clinics, inpatient wards, and intensive care units requested the majority of EEGs. Epilepsy, presyncope/syncope, and psychogenic non-epileptic seizures (PNES) were the top reasons for EEG requests. Among the newly diagnosed epilepsy patients, 13 showed abnormal EEG results. The study identified MRI abnormalities in 202 patients, with a 27% concordance between EEG and MRI findings. EEG significantly influenced patient management in 577 cases (46.5%), demonstrating its crucial role in clinical decision-making.
Conclusion: EEG's diagnostic value, particularly in epilepsy and complex neurological conditions, remains unique. Advocating suiting EEG requests and increasing physician knowledge of seizures can optimize patient care and resource use.
Bariatrik Cerrahi Sonrası Ortaya Çıkan Mide Adenokarsinomu: Obezite ve Mide Kanseri Arasındaki Genetik İlişkinin İncelenmesi
Authors: Şahin Sümeyye , Eren Keskin Seda , Şahin Enes , Sünnetçi Akkoyunlu Deniz , Doğruoğlu Buket , İlkay Zeynep , Güler Sertaç Ata , Çine Naci , Sahin Mustafa
Published: October 2024

Dünya genelinde ciddi bir sağlık sorunu olan obezitenin en etkin tedavisi olarak cerrahi işlemler uygulanmaktadır. Sleeve gastrektomi en sık uygulanan obezite cerrahisi tekniğidir. Obez bireylerde kanser riskinin arttığına dair görüşler mevcuttur. Ancak obezite cerrahisi sonrası da mide kanseri gelişen bazı olgular bildirilmiştir. Morbid obezite tanısı ile sleeve gastrektomi uygulanan bir hastanın ameliyatından 8 ay sonra dispeptik şikayetleri gelişmeye başlamıştır. Tetkikler neticesinde striktür tanısı konulan hastaya gastrik bypass revizyon cerrahisi uygulanmıştır. Hastanın bu operasyonundan sonra da şikayetlerinin devam etmesi üzerine yapılan detaylı incelemede hastaya mide adenokarsinomu tanısı konulmuştur ve hastaya total gastrektomi ameliyatı yapılmıştır. Obezite ciddi bir sağlık problemi olmasının yanında beraberinde birçok hastalık içinde risk faktörü olarak değerlendirilmektedir. Obez bireylerde kanser riskinin arttığı yönünde literatürde ciddi çalışmalar mevcuttur. Ancak obezite cerrahisi sonrasında kanser riskinin arttığına yönelik bazı çalışmalar mevcut olsa da henüz genel bir kanı oluşmamıştır. Ancak kanser riski artmış olan obez bireylerde cerrahi tedavi öncesinde kanser taraması amacıyla kontrol endoskopi yapılması ciddi şekilde önerilmektedir.
The Effects of Rosemary (Rosmarinus Officinalis L.) Extract on the Proliferation and Apoptosis of A549 and H1299 Human Lung Cancer Cells
Authors: Alimoğulları Ebru , Kartal Bahar , Özdemir Sancı Tuba , Aslan Erdem Sinem , Ceylan Aslı
Published: October 2024

ABSTRACT
Objective: Apoptosis resistance and increased proliferation rates are characteristics of cancer cells. The anticancer properties of rosemary (Rosmarinus officinalis L.) extract (RE) have been demonstrated in a small number of in vivo and in vitro animal studies; however, no research has investigated the role of RE in human non-small cell lung cancer (NSCLC) A549 and H1299 cells, and its underlying mechanism of action remains unknown. In the current study, we examined the effects of RE on human non-small cell lung cancer cell proliferation, survival, and apoptosis.
Methods: Human non-small cell lung cancer (NSCLC) A549 and H1299 were incubated with (2.5 µg/ml, 5 µg/ml, 7.5 µg/ml, 10 µg/ml, and 12.5 µg/ml) doses of RE for 12, 24, and 48 hours. MTT, Annexin V-PI, and caspase 3/7 assay kit were performed to detect the cell viability and apoptosis.
Results: According to MTT analysis, the viability of A549 and H1299 human lung cancer cells was reduced by approximately 49.74% and 47.76%, respectively, for 24 hours by treatment with a dose of 5 µg/ml RE. The results of Annexin V-PI staining and Caspase 3/7 activation showed that RE had a greater effect on inducing cell death.
Conclusion: In conclusion, we can say that rosemary extract has both apoptotic and antiproliferative properties on human lung cancer cells. We might propose that additional investigation is necessary to ascertain the therapeutic impacts of rosemary extract.
Beyond The Patient: Exploring The Psychological Burden On Caregivers Of Multiple Sclerosis Patients
Authors: Sarıkaya Cansu , Efendi Hüsnü
Published: October 2024

Introduction: Multiple sclerosis is a chronic, progressive disease, leading to significant psychological impacts on patients and their caregivers. This study focuses on the psychological impact on caregivers of Multiple Sclerosis patients, particularly examining the correlation between the severity of disability and depression, caregiver burden and self-stigma.

Methods: The study included 65 Multiple Sclerosis patients and their caregivers. Caregivers were assessed using the Beck Depression Inventory, ZARIT Burden Interview, Self-Stigma of Depression Scale and patients were evaluated using the Expanded Disability Status Scale. Statistical analysis was performed using IBM SPSS Statistics 17.

Results: The study found higher scores in Beck Depression Inventory, Self-Stigma of Depression Scale and ZARIT Burden Interview among female caregivers, indicating a greater burden. Unemployment and lower educational backgrounds were significantly correlated with increased caregiver burden. A positive correlation was observed between the severity of the patient's disability and caregiver burden. Caregivers with mental illnesses reported higher levels of burden and depression.

Conclusion: The study underscores the multifaceted impact of Multiple Sclerosis on caregivers, highlighting the need for comprehensive care approaches that include psychological support, education, and socio-economic assistance for caregivers. This holistic approach is essential for improving the overall management of Multiple Sclerosis, benefiting both patients and their caregivers.
Retrospective Evaluation of Patients Who Received Surgery as the First Option in the Treatment of Green Type 3-4 Trigger Finger
Authors: Gök Ümit , Selek Özgür
Published: October 2024

AİM: To evaluate the clinical and functional outcomes of the patients with trigger finger patients who are treated by open surgery method without applying conservative treatment modalities
METHODS: Open A1 pulley surgical release under local anesthesia was applied to 67 trigger finger patients ( 45 female, 22 male, mean age 53,82, range 11-81). The mean follow-up was 38,37 months (range 4-76 months). As assosiated pathologies, there were type 2 DM in 14 and chronic renal failure in 1 patients.
RESULTS: In 67 patients pain and triggering were found to be treated by open surgical A1 pulley release. No recurrence seen in triggering nodularity. Postoperatively there were no significant neurovascular complications noted
CONCLUSION: As similar to literature, we believe that in the treatment of trigger finger with open surgery method is a safe and effective method and also supplies fast return to daily life. We think that the surgery may be the first choice in selected cases.
Kidney Health Consequences of Patients with Glomerulonephritis; Before and After SARS-COV2 Infection
Authors: Dönmez Buse , Güler Özlem , Ergül Metin , Bek Sibel
Published: October 2024

Objective: The virus that causes severe acute respiratory syndrome (SARS-CoV-2) was first identified in Wuhan, China, in December 2019. Recent studies have proven that SARS-CoV-2 is also a nephrotrophic virus.
Methods: Our study aimed to evaluate kidney function and general kidney health of patients with previously diagnosed glomerular diseases and follow-up after SARS-CoV-2 infection. For this purpose, the data of 36 patients who were diagnosed with and routinely followed up for glomerulonephritis and had SARS-CoV-2 infection at the Kocaeli University Faculty of Medicine Hospital nephrology outpatient clinics between January 2020 and January 2022 were examined before and after the infection.
Results: No significant differences were observed in serum creatinine, estimated glomerular filtration rate, and 24-hour urine protein values after infection. There was an increase in platelet and albumin levels following the SARS-CoV-2 infection. A significant decrease was detected in 24-hour urine creatinine values.
Conclusion: The results of the study showed that kidney function and general kidney health of patients with SARS-CoV-2 infection diagnosed with glomerulonephritis were not different when compared to their condition before SARS-CoV-2 infection.
BAŞ BOYUN KANSERLERİNDE ONKOGENLER VE TÜMÖR BASKILAYICI GENLER
Authors: Bayramova Günel , Ertugrul Baris , Kaşarcı Göksu , Bireller Sinem , Çakmakoğlu Bedia
Published: October 2024

Baş ve boyun kanserleri (BBK), ağız boşluğu, farenks, gırtlak, burun boşluğu ve tükürük bezleri gibi baş ve boyun çevresindeki anatomik bölgelerden kaynaklanan çeşitli malignite gruplarını kapsar. Bu kanserlerin gelişimi ve ilerleyişi, özellikle tümör baskılayıcı genler ve onkogenleri içeren genetik ve/veya epigenetik değişikliklerle karmaşık bir şekilde bağlantılıdır. Tümör baskılayıcı genler, hücre döngüsü regülasyonu, genomik stabilitenin korunması ve tümör oluşumunun önlenmesi gibi mekanizmalarda kritik rol oynarlar. Bu genlerin inaktivasyonu kontrolsüz hücre çoğalması ve kanser gelişimi ile sonuçlanabilmektedir. Öte yandan, onkogenler ise hücre büyümesini ve bölünmesini destekleyen ve proto-onkogen olarak adlandırılan normal genlerin mutasyona uğramış veya aşırı eksprese edilmiş versiyonlarıdır. BBK’nde onkogenlerin aktivasyonu, malign dönüşümü ve tümör büyümesini uyarmaktadır. Bu genlerin rollerinin anlaşılması, BBK de dahil olmak üzere tüm kanser türlerinde altta yatan moleküler mekanizmaların aydınlatılması ve kişiye özel tedavi stratejilerinin geliştirilmesinde bu mekanizmaların hedeflenerek daha spesifik bir tedavi uygulanması açısından önem taşımaktadır.
Morphological Evaluation of Corpus Callosum Atrophy Over Time in Relapsing Remitting Multiple Sclerosis
Authors: Kılıç Buket , Tekin Ayla , Bünül Sena Destan , Efendi Hüsnü , Çakır Özgür , Çolak Tuncay , Balcı Sibel
Published: October 2024

Objective: Multiple sclerosis (MS) is a chronic central nervous system (CNS) disease that generally affects young adults and is marked by inflammation, demyelination, and neurodegeneration. Magnetic resonance imaging (MRI) is widely used diagnosis tool for relapsing remitting MS (RRMS). Corpus callosum (CC), the largest commissural tract in brain which is associated with both cognitive and physical impairment by atrophy in MS. Our study aimed to evaluate CC in RRMS patients using MR images and compare it to measurements from healthy controls within the same age.
Methods: We manually measured changes in CC thickness in T1 brain MR images of RRMS patients in 2017, 2019, and 2022.
Results: Our results showed that control group had greater thickness, length, and index values in all CC sections compared to patient group. Additionally, a significant difference was observed in thickness of genu and splenium sections and CC index between patient and control groups. However, no significant difference was detected in truncus part of CC or overall CC length. CC measurements in patient group decreased over time, with 1st MRI showing greater values than 2nd and 3rd MRI scans. Furthermore, there was a statistically significant difference in thickness of truncus part of CC and volume values of subcortical areas between 2nd-3rd and 1st-3rd MRI measurements.
Conclusion: As a result of these findings, our study provides important information about changes in CC measurements for MS patients.
KeraRing Implantation with Femtosecond Laser in Keratoconus Treatment at Different Stages
Authors: Ulukartal Ayşem Gül , Solmaz Nilgün , Feyza Önder
Published: October 2024

Objective: To investigate the reliability and effectiveness of femtosecond laser-assisted KeraRing (Mediphacos, Belo Horizonte, Brazil) implantation in treating keratoconus.
Methods: Intrastromal corneal ring segments (KeraRing, Mediphacos, Brazil) were implanted in 15 eyes of 14 patients unable to tolerate contact lenses. Femtosecond laser (Intralase, 60 Hz) was used for corneal tunnel creation. Based on the distribution of ectatic area on the cornea, dual segments were implanted in 9 eyes, while single segments were implanted in 6 eyes. Preoperative and postoperative uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA), objective and subjective refraction, and topographic corneal curvature (K) values of the cases were compared using the Wilcoxon test.
Results: The mean age of patients was 25±7.46 (range: 15-39) years, with a mean postoperative follow-up period of 10.8±7.37 (range: 1-24 months). BCVA improved in all eyes during the follow-up period, increasing from a mean of 0.12±0.1 to 0.38±0.24 (p
Timokinon, sağlıklı sıçanlarda hipokampal miR-26b, miR-124 ve miR-29a mikroRNA'larının ekspresyonlarını etkiler
Authors: Doğan Mollaoğlu Ayça , Beker Merve , Dallı Tuğçe , Elibol Birsen
Published: October 2024

Amaç: Nigella sativa'nın ana biyoaktif bileşeni olan Thymoquinone (TQ), kan beyin bariyerini geçerek nöroprotektif ve nöromodülatör aktiviteler gösterir. Bu çalışmanın amacı, TQ uygulamasının sağlıklı sıçanların hipokampüsünde 26b, 124, 29a ve 29c mikroRNA'larının (miR) ekspresyonları üzerindeki etkisini araştırmaktır.
Yöntem: TQ (20 mg kg-1 d-1) yetişkin sıçanlara 15 gün boyunca intragastrik olarak uygulanmıştır. İlgili genlerin mikroRNA seviyeleri gerçek zamanlı polimeraz zincir reaksiyonu kullanılarak analiz edilmiştir.
Bulgular: TQ uygulaması miR-26b ve miR-124'ün ifade profillerini önemli ölçüde aşağı düzenlerken miR-29a'nın ifadesini yukarı düzenlemiştir. miR-29c'nin ifade düzeyinde anlamlı bir etki gözlenmemiştir.
Sonuç: TQ, beyinde yüksek oranda ifade edilen miR-26b, miR-124 ve miR-29a'nın ifadelerini değiştirerek sağlıklı beyin ve/veya merkezi sinir sistemi fonksiyonlarında faydalı bir role sahip olabilir.
Theoretical Thinking on the Development of New Quality Productive Forces According to Local Conditions in Heilongjiang Province
Authors: Shen Haoran , Li Yan
Published: October 2024

The new quality productive forces reflects the systematic remodeling and revolutionary transition of the old productive forces, which is the quality of productivity in line with the requirements of high-quality development. The formation of new quality productive forces can effectively energize the revitalization and development of Heilongjiang Province. From the perspective of the revitalization of the old industrial base in Northeast China, opportunities, advantages and challenges coexist in the development of new quality productive forces in Heilongjiang Province. Based on the current situation, the practical path for the development of new quality productive forces according to local conditions in Heilongjiang Province is proposed: Cultivate innovative thinking leading the development of new quality productivity, form the industrial base for the development and growth of new quality productivity, shape the innovation economic system for the development of new quality productivity, and build innovation clusters of new quality productivity.
Research on A Task-Based Teaching Model for Cruise Ship Professional English
Authors: Zhang Xiaowei , Jiang Rui
Published: October 2024

This paper aims to explore a task-based teaching model for cruise professional English. By analyzing the development of the cruise industry and the current status of cruise professional English teaching, it reveals the existing problems and challenges in teaching. Based on this, a task-based teaching model is constructed, and the theoretical basis, task analysis and design, and specific implementation steps of the model are elaborated. The effectiveness of the teaching model is verified through empirical research, and targeted teaching suggestions are proposed. This study aims to provide new ideas and methods for cruise professional English teaching to improve teaching quality and effectiveness.
The Prevention and Management System of Public Emergencies based on Community
Authors: Huang Juan
Published: October 2024

With the in flux of population and the increasingly complex changes of social structure, more and more public emergencies spread from the community grass‐roots level to all over the world. The occurrence of large‐scale public emergencies around the world makes its prevention and governance enter the research field of vision again. The role of grass‐roots communities in the prevention and response of public emergencies is becoming more and more important, because it is not only related to the life and health of grass‐roots people, but also of great significance to maintain that our country is and will be in the primary stage of socialism for a long time and the long‐term stable development of economy and society. This document makes a preliminary analysis and report on the prevention and management of community grass‐roots response to public emergencies, and these problems will attract extensive attention of the people, and improve the attention of grass‐roots communities to the disposal of public emergencies.
Research on the Utilization of School Resources in Young Pioneers Activities from the Perspective of Political Socialization
Authors: Zhang Ruolan
Published: October 2024

At present, there are some problems in the utilization of school resources in the Activities of young Pioneers, such as narrow content, weak awareness of school and members, and mere formality. Under the background of the current reform of Young Pioneers, through the reorganization of existing resources, exercise the quality of activities, respect for the dominant position of members, improve the working mechanism and strengthen information guidance, In order to achieve the purpose of promoting the development of political socialization of children and the significance of the activities of young pioneers.
On the Dialectics of Slavoj Zizek —Reinterpretation of Hegel and Schelling
Authors: Yan Fengyu
Published: October 2024

While "repeating Lenin" on the political, Zizek is also reviving dialectical materialism in philosophy. His theoretical opponents are mainly discourse materialism and new materialism. The main problem of the former is the identity politics of multiculturalism, and the latter is that the return to vitalism covers up the rift between subject and object. Zizek attempts to introduce concepts such as Lacan's death drive and signifier logic into the philosophy of Hegel and Schelling in order to rediscover materialism. In the interpretation process, we can see Zizek's use of dialectics.
Shi Lu and Fine Arts Magazine: Resonance in the Age of Art
Authors: Wang Ruiyang
Published: October 2024

Fine Arts magazine paid attention to and discussed Shi Lu for about six years in the 1950s and 1960s. It witnessed his transformation from traditional style to "strange changes in ink and brushwork" and the expansion of his subject matter. It also triggered discussions on the balance between traditional inheritance and innovation, as well as the renewal of critical standards. Through discussing Shi Lu's works, the magazine tries to guide the direction of Chinese painting creation, encourage attention to reality and innovation, construct a new discourse system and image paradigm, and trigger thoughts on tradition, innovation, and standards.
Key Elements and Theoretical Logic of Genderless Clothing Design: An Analysis Based on Rooted Theory
Authors: Wang Qinghui , Ji Enfeng , Qv Na
Published: October 2024

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Research on the Path of Cultivating College Students' Values Through Chinese Poetry Culture
Authors: Chen Yawen , Tang Haiyuan
Published: October 2024

Chinese poetry has rich cultural connotations and plays a role in moral cultivation education, struggle spirit education, and patriotism education. However, at present, the cultivation of values among college students through Chinese poetry still faces challenges such as limited dissemination of Chinese poetry in university classrooms, insufficient campus cultural atmosphere, insufficient social practice activities, and weakening in online trends. To cultivate values among college students through Chinese poetry culture, it is necessary to optimize classroom teaching, construct educational carriers, shape "campus culture", enrich social practice, leverage online classrooms, and build a new situation of multi-faceted and interconnected education.
Developing Vocational Education and Deepening the Integration of Industry and Education Providing Human Resources Support for Building a Strong Provincial Centre-Taking the Development of Vocational Education in Sanmenxia as an Example
Authors: Wang Jiaying
Published: October 2024

Since the 18th National Congress of the Communist Party of China (CPC), China's vocational education has experienced significant improvement and optimisation, and the group of graduates from vocational colleges and universities has grown to become the backbone of China's industrial army, which not only provides a solid support for the vigorous development of small and medium-sized enterprise clusters, but also greatly promotes the transformation and upgrading of the regional industry, and accelerates the process of urbanization, which has become an important driving force for the socio-economic development of the society. In recent years, Sanmenxia City has paid special attention to the development of vocational education in the process of strengthening the construction of provincial centre city, and has cultivated a large number of high-quality technical talents, which has provided a solid talent foundation for the transformation and development of the city's economy and society. Taking the development of vocational education in Sanmenxia as an example, this paper focuses on the inevitability and positive contribution of vocational education to the construction of Sanmenxia as a provincial central city, analyses the current situation, and puts forward countermeasures and suggestions for the future of vocational education in the provision of talent support for the construction of a provincial central city.
Enhancing Cross-Cultural Understanding: The Role of Digital Platforms in Cultural Exchange for Chinese Graduate Students at Northwestern University
Authors: Dang Shangdi
Published: October 2024

The rapid growth of digital platforms has reshaped the educational-rich landscape, introducing dynamic ways of cultural exchange that transcend traditional boundaries. This paper explores the unique potential of online cultural exchange to promote cross-cultural understanding and community building for students, with a special focus on Chinese graduate students in Northwestern University during their short spring break. As global connectivity increases, it becomes increasingly important to leverage these digital tools to facilitate meaningful cultural interactions. This study argues that social media platforms play a key role in this effort, enabling students to engage in cultural exchange activities that are both convenient and impactful (Abbas et al., 2019). Integrating digital tools into educational and cultural environments has revolutionized the way students interact with different cultural experiences. Social media platforms, in particular, offer unparalleled opportunities for students to connect with peers from different cultures, share knowledge and engage in collaborative activities. These platforms provide a flexible and accessible means for students to immerse themselves in cultural learning outside of geographical constraints. Moreover, the interactivity of social media fosters a sense of community and common purpose, which is essential for successful cultural exchange programs. While there are many advantages to using social media for cultural communication, there are also significant challenges that need to be addressed. The potential for distraction, information overload, and reduced face-to-face interaction could undermine the effectiveness of these platforms in educational Settings. In addition, given the differences in social media usage patterns among different demographic groups, such as gender differences, it is critical to ensure that programs are inclusive and effective. This article aims to explore these complexities and offer solutions to maximize the benefits of social media while mitigating its drawbacks.
Personality Dynamics and the Impact of Life Events
Authors: Liu Huaying , Guo Hongfu , Yang Borui
Published: October 2024

Understanding personality dynamics in response to life events is crucial for comprehending individual differences in social behavior. The introversion-extraversion spectrum, developed by Carl Jung, offers a framework to explore how individuals channel their energy. This spectrum, initially perceived as a dichotomy, is now recognized as a continuum, with most individuals exhibiting traits of both introversion and extraversion. Life events encompass significant occurrences or milestones that profoundly impact an individual's life, either positively or negatively. Despite the growing importance of this relationship, there is a lack of experimental research exploring the causal impact of life events on introversion-extraversion traits. This research aims to enhance understanding of how life events influence personality traits, with a particular focus on the interplay between intra-psychic and extra-psychic factors, and discussing how introverts and extroverts manage their behavior in different environments. Utilizing a questionnaire survey method and validated psychometric instruments, data from 203 participants will be analyzed to understand the complex interplay between personality traits and life events. The findings contribute to our understanding of personality dynamics and have implications for interventions aimed at promoting psychological well-being.
Marginalized People and the Big World: on the Multiple Narrative Modes of Microhistory
Authors: Wang Lexuan
Published: October 2024

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A Study on the Cultivation of Autonomous Learning Ability in College English Teaching
Authors: Zhang Xiaowei , Jiang Rui
Published: October 2024

This paper aims to explore the cultivation of autonomous learning ability in college English teaching. Through literature review, current situation analysis, and empirical research, the article deeply analyzes the current problems and influencing factors of cultivating autonomous learning ability in college English teaching, and proposes targeted cultivation strategies and methods. Research results show that optimizing curriculum and teaching methods, enhancing students' autonomous learning motivation and interest, and cultivating students' autonomous learning habits and abilities are important ways to effectively improve college students' English autonomous learning abilities. The research results of this paper provide a useful reference for the reform and development of college English teaching.
OBE-based Lab Opening Model Construction in Navigation Technology
Authors: Huang Xian
Published: October 2024

Carried by the opening of maritime technological laboratories, depended upon technical means of informationalization, we try to realize the intellectual opening of laboratories. Meanwhile, we also, by the means of establishing scientific and high-efficient opening management systems, carry out classified and storied opening pattern, and implement the connotation of Obe concept, integrate OBE concept into the talent cultivation of navigation technology so as to fully develop the educating effect of professional laboratories and assis in the high-level talent cultivation in navigation technology.
Discourse Historical Analysis of Identity Construction of New Energy Enterprises in China and the United States
Authors: Zhang Mengni , Zhang Mengni , Zhang Mengni
Published: October 2024

In recent years, with the increasing awareness of climate change and environmental protection, new energy vehicles have gradually become a hot topic in the automotive industry. This article uses the Social Responsibility Report of BYD and Impact Report of Tesla as corpus, adopts a discourse-history research approach to analyze the three-dimensional framework of discourse analysis, and uses the corpus tool Wmatrix 6.0 to analyze the macro-themes, meso-discourse strategies, and micro-language features of corporate identity construction in China and the United States, explaining their similarities and differences in the construction of new energy enterprise identities. This study provides reference for the identity construction of new energy enterprises in China, and has practical significance for enhancing the international discourse construction ability of Chinese new energy enterprises.
Advances in Fuzzy Linguistics Research in the Last Two Decades - CiteSpace-based Visualisation and Analysis
Authors: Cheng Xiaoli
Published: October 2024

This paper analyzes the research progress of fuzzy linguistics in the last two decades based on the visual analysis method of CiteSpace. It introduces the concept and development background of fuzzy linguistics. In this paper, the research progress in the field of fuzzy linguistics is explored in depth through visual analysis using CiteSpace, and the related research directions and development trends are discussed and summarized in detail. The results of these analyses are of certain reference significance for further in-depth research in the field of fuzzy linguistics and for advancing the technological development and application in the field of fuzzy linguistics.