bluuebunny/crossref_metadata_2025 huggingface dataset:
Síndrome del incisivo central único de la línea media del maxilar y fusión de incisivos centrales permanentes mandibulares: Reporte de un caso clínico
Authors: Mendoza Velasco Dulce María , Fragoso Ramírez J Antonio , Yamamoto Nagano Adolfo
Published: September 2022

El síndrome del incisivo central único, es una anomalía poco frecuente, la cual se caracteriza principalmente por malformaciones estructurales del macizo craneofacial. La característica clínica más significativa la encontramos en la cavidad bucal, con la presencia de un incisivo único sobre la línea media del maxilar en ambas denticiones (temporal y permanente). Este reporte clínico describe el caso de un paciente femenino de 6 años que se presentó en la Clínica de Odontopediatría de la División de Estudios de Posgrado e Investigación de la Facultad de Odontología de la UNAM, donde radiográficamente se observó la presencia de un incisivo único permanente sobre la línea media del maxilar y clínicamente la presencia de otras anomalías, tales como: ausencia del frenillo labial superior, fusión de incisivos centrales mandibulares y paladar oval. La presencia del incisivo único siempre estará asociada a otras anomalías, tales como: déficit de la hormona de crecimiento y síndrome triple X; además de considerarse un signo predictor de holoprosencefalia.
La estereolitografía en la Facultad de Odontología de la UNAM
Authors: Jiménez Castillo René , Benavides Ríos Alejandro
Published: September 2022

La estereolitografía tiene sus orígenes en los sistemas de Diseño Asistido por Computadora (CAD), los cuales son programas de cómputo que aceleran los procesos de diseño. El primer programa de sistemas CAD data de 1963 en EUA, pero fue en 1982 cuando se consolidó el uso de diseño asistido por computadora. El programa dio un gran salto cuando pocos años después se incorporaron a éstos, los sistemas de Diseño Asistido por Computadora en Tercera Dimensión (CAD3D), dando lugar a métodos de fabricación de modelos tridimensionales por capas en diversos materiales de manera rápida y económica (Rapid Tooling).
Plasma rico en factores de crecimiento en cirugía bucal: Presentación de caso clínico
Authors: Fernández López Rocio Gloria , López Buendía Ma Del Carmen , Ruiz González Eréndira
Published: September 2022

El objetivo del trabajo fue utilizar plasma autólogo rico en factores de crecimiento (PRGF) para mejorar la respuesta quirúrgica, estimulando los mecanismos de reparación, mediante la técnica de regeneración ósea y tisular, desarrollada por Biotechnology Institute, SL. Este es un sistema para la obtención de proteínas, a partir de la propia sangre del paciente momentos antes de su utilización. Se presenta un caso de odontoma compuesto compositum de 3 x 4 cm de diámetro mayor en el proceso alveolar anterior del maxilar y la retención del órgano dentario central superior izquierdo, los cuales fueron enucleados. En el sitio del defecto quirúrgico, se colocó plasma rico en factores de crecimiento (PRGF), con material de injerto de hidroxiapatita reabsorbible, observando un mejor manejo del mismo, así como menor tiempo en la cicatrización de la herida
El financiamiento integral a la investigación científica: UNAM política necesaria para el largo plazo
Authors: Mendez Blanco Juan Pablo
Published: September 2022

En los albores del siglo XXI, México continúa en la mayoría de los casos, nutriéndose de ciencia ajena y de soluciones importadas, por lo tanto los investigadores mexicanos, para contrarrestar este hecho, hacemos ciencia propia con lo que contribuimos al concierto internacional del saber, nuestra producción es variada y con frecuencia innovadora, pero aún queda un largo trecho por andar. Al igual que hace más de 50 años, contamos con algunos hombres de ciencia o grupos de investigación de alto nivel internacional, sin embargo, éstos constituyen todavía casos aislados de excepción que han conseguido grandes logros por su ímpetu y capacidad. La falta de políticas integrales a largo plazo y la inmediatez, no han permitido un desarrollo cabal de la investigación; no podemos esperar ya más, el país tiene que impulsar clara y enfáticamente el quehacer científico.
Evaluación in vitro de la citotoxicidad de tres selladores endodóncicos sobre fibroblastos de ratón
Authors: Peralta Pérez Magnolia , Uribe Querol Eileen , García Aranda Raúl Luis , Gutiérrez Opsina G
Published: September 2022

Los selladores endodóncicos pueden causar citotoxicidad en los tejidos periapicales después de un tratamiento de conductos. En general, las pruebas de biocompatibilidad in vitro realizadas a los selladores evalúan su citotoxicidad cuando éstos ya endurecieron, lo que limita la evaluación de sus efectos durante la aplicación aguda; condición observada en la clínica. En el presente trabajo se evaluó la citotoxicidad de tres selladores: AH-Plus™, RoekoSealAutomix® (RSA) y Roth Root utilizando un dispositivo que permite evaluar los efectos de los selladores durante su fase de polimerización. Cultivos de fibroblastos murinos fueron expuestos a los distintos selladores durante 6, 12, 24, 36, 48 y 72 horas. Después de cada periodo de tiempo se evaluó la morfología celular por microscopia de luz y la viabilidad mediante la prueba de exclusión del azul tripano. La morfología de fibroblastos expuestos al RSA no se altera. Sin embargo, al exponerlos a los otros dos selladores la mayor parte de los fibroblastos se despegan después de las primeras 6 horas. El ensayo de viabilidad muestra que el número de fibroblastos fue muy parecido entre el grupo control y el grupo expuesto a RSA a lo largo del curso temporal. En contraste, la muerte de fibroblastos es evidente desde las primeras 6 horas de exposición al AH-Plus™ y al Roth Root. En conclusión, debido a que el RSA no mostró citotoxicidad, parece que los selladores con base de silicona constituyen la primera elección para el tratamiento de conductos.
Estudio in vitro del deterioro de las propiedades elásticas de las cadenas elastoméricas
Authors: Sánchez Herrera Ma Lurim , Katagiri Katagiri Mario , Álvarez Gayoso Carlos
Published: September 2022

La elasticidad de las cadenas elastoméricas sufre un deterioro gradual al ser sometidas a una fuerza tensional constante debido a la ruptura de sus estructuras moleculares por acción de diversos factores ambientales. Objetivo: Analizar en las cadenas elastoméricas el deterioro de la fuerza a causa de un alargamiento constante en tres marcas comerciales en diferentes periodos. Método: Se elaboraron 10 muestras de cada marca comercial de cadena elastomérica (GAC, TP y 3M UNITEK) de 5 módulos cada una y se sometieron a tensión, midiendo la fuerza inicial, a los 30 min, 24 horas y 4 semanas. Los valores del alargamiento se obtuvieron a los 30 minutos, 24 horas y 4 semanas. Los valores se examinaron con una prueba de Friedman para determinar las diferencias estadísticamente significativas entre las 3 marcas. Resultados: Se encontró que la marca que presenta un comportamiento más uniforme tanto en las pruebas de fuerza como en las de alargamiento es GAC, mientras que TP tiene valores de fuerza altos y menores de alargamiento y 3M pierde mayor cantidad de fuerza y tiene mayor alargamiento.
Grado de sellado de materiales de obturación temporal en molares primarios con pulpotomía: estudio in vitro
Authors: Dittel Balma Ana Marcela , Garrocho Rangel José Arturo , Méndez González María Verónica , Hernández Sierra Juan Francisco , Pozoz Guillén Amaury de Jesús
Published: September 2022

El objetivo del estudio fue comparar el grado de sellado marginal e interfase dentinaria de diferentes materiales de restauración temporal en molares temporales con pulpotomía. Se realizó un estudio experimental in vitro en 51 piezas dentales extraídas, divididos en 3 grupos de estudio de 17 molares, todas las piezas recibieron tratamiento de pulpotomía, después del cual se colocó el material de restauración temporal en el espacio de la cámara pulpar: A. Ionómero de vidrio Fuji IX. B. CAVIT. C. IRM. Se evaluó la pérdida de sellado marginal y presencia de interfase con la pared dentinaria por medio del microscopio óptico polarizado de transmisión. Se encontraron diferencias estadísticamente significativas entre los grupos de estudio (p < 0.05); existiendo un menor grado de sellado en el grupo del ionómero de vidrio Fuji IX evidenciando la presencia de filtración marginal, lo que puede ocasionar el fracaso del tratamiento. CAVIT e IRM se comportaron de forma muy similar en sus propiedades de sellado.
Trascendencia de la Facultad de Odontología UNAM, en la formación de recursos humanos extranjeros
Authors: Ruíz Rodríguez Rafael
Published: September 2022

La Universidad Nacional Autónoma de México, ha sido formadora de grandes líderes y pensadores mexicanos; de científicos, y profesionistas destacados del país, de ganadores del Premio Nobel, así como de fundadores y maestros de escuelas y facultades de toda nuestra nación.Una de las misiones de la Universidad es extender el conocimiento, sus proyectos académicos y de investigación, en fin, extenderse toda ella no sólo en forma nacional sino también hacia los hermanos de aquella raza cósmica de la que habló José Vasconcelos, la Raza Latinoamericana.
Kualitas Fisikokimia pada Madu dari Nektar Bunga Randu (Ceiba pentandra) dan Kaliandra (Calliandra callothyrsus)
Authors: Triwanto Joko , Herlinda Kiki , Muttaqin Tatag
Published: September 2022

Lebah madu jenis A. mellifera adalah serangga penghasil madu yang memperoleh pakan dari nektar bunga randu, dan kaliandra. Perlu dilakukan penelitian pakan nektar bunga kaliandra, dan randu dengan lebah A. mellifera, sehingga perlu dilakukan pengujian kualitas fisikokimia seperti bau, rasa, warna, dan sifat kimianya seperti pH, kadar air, dan  kadar gula untuk membedakan ciri khas kedua madu, dan mendapatkan jenis madu berkualitas unggul. Tujuan penelitian mengkaji ciri khas, dan membandingkan kualitas madu randu, dan kaliandra berdasarkan nilai fisikokimia. Metode penelitian analisis deskriptif dengan pendekatan kuantitatif. Hasil analisis adanya perbedaan yang nyata antar kedua madu yakni memiliki bau, rasa, warna, pH dan kadar air sesuai dengan standar yang ditetapkan serta kebersihan madunya bersih, dan disukai panelis. Berdasarkan perbandingan madu kaliandra mendapatkan poin tertinggi (8) diperoleh dari skor rasa, bau, warna, kebersihan, kesukaan, pH, kadar air, dan kadar gula. Sedangkan madu randu mendapatkan poin terendah (3) diperoleh dari skor kesukaan, pH, dan kadar air.
An innovative quality lane change evaluation scheme based on reliable crowd-ratings
Authors: Psaraftis Konstantinos , Anagnostopoulos Theodoros , Ntalianis Klimis
Published: September 2022

Intelligent Transportation Systems (ITSs) and their applications are attracting significant attention in research and industry. ITSs make use of various sensing and communication technologies to assist transportation authorities and vehicle drivers in making informative decisions and provide leisure and safe driving experience. Data collection and dispersion are of utmost importance for the proper operation of ITSs applications. Numerous standards, architectures and communication protocols have been anticipated for ITSs applications. In recent years, crowdsourcing methods have shown to provide important benefits to ITSs, where ubiquitous citizens, acting as mobile human sensors, help respond to signals and providing real-time information. In this paper, the problem of mitigating crowdsourced data bias and malicious activity is addressed, when no auxiliary information is available at the individual level, as a prerequisite for achieving better quality data output. To achieve this goal, an innovative algorithm is designed and tested on a crowdsourcing database of lane change evaluations. A three-month crowdsourcing campaign is performed with 70 participants, resulting in a large number of lane changes evaluations. The proposed algorithm can negate the noisy ground-truth of crowdsourced data and improve the overall quality.
Critical Role for Macrophages in the Developmental Programming of Pancreatic β-Cell Area in Offspring of Hypertensive Pregnancies
Authors: Root Kate M. , Akhaphong Brian , Cedars Melissa A. , Molin Alexa M. , Huchthausen Margaretta E. , Laule Connor F. , Regal Ronald R. , Alejandro Emilyn U. , Regal Jean F.
Published: September 2022

Preeclampsia is a pregnancy-specific complication with long-term negative outcomes for offspring, including increased susceptibility to type 2 diabetes (T2D) in adulthood. In a rat reduced uteroplacental perfusion pressure (RUPP) model of chronic placental ischemia, maternal hypertension in conjunction with intrauterine growth restriction mimicked aspects of preeclampsia and resulted in female embryonic day 19 (e19) offspring with reduced β-cell area and increased β-cell apoptosis compared with offspring of sham pregnancies. Decreased pancreatic β-cell area persisted to postnatal day 13 (PD13) in females and could influence whether T2D developed in adulthood. Macrophage changes also occurred in islets in T2D. Therefore, we hypothesized that macrophages are crucial to reduction in pancreatic β-cell area in female offspring after chronic placental ischemia. Macrophage marker CD68 mRNA expression was significantly elevated in e19 and PD13 islets isolated from female RUPP offspring compared with sham. Postnatal injections of clodronate liposomes into female RUPP and sham offspring on PD2 and PD9 significantly depleted macrophages compared with injections of control liposomes. Depletion of macrophages rescued reduced β-cell area and increased β-cell proliferation and size in RUPP offspring. Our studies suggest that the presence of macrophages is important for reduced β-cell area in female RUPP offspring and changes in macrophages could contribute to development of T2D in adulthood.
Differences in the Association of Select Dietary Measures With Risk of Incident Type 2 Diabetes
Authors: Tison Stephanie E. , Shikany James M. , Long D. Leann , Carson April P. , Cofield Stacey S. , Pearson Keith E. , Howard George , Judd Suzanne E.
Published: September 2022

OBJECTIVE

To evaluate associations between a broad range of approaches to classifying diet and incident type 2 diabetes in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study.

RESEARCH DESIGN AND METHODS

This study included 8,750 Black and White adults without diabetes at baseline. Diabetes was defined according to fasting glucose ≥70 mmol/L, random glucose ≥111 mmol/L, or use of diabetes medications. The exposures were diet scores for Mediterranean and Dietary Approaches to Stop Hypertension (DASH) diets and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND), dietary inflammatory index (DII), dietary inflammation score (DIS), and empirical dietary patterns (plant-based and Southern) determined using data collected with use of the Block98 food-frequency questionnaire. Modified Poisson regression was used to assess association of dietary measures with risk of incident type 2 diabetes, with models adjusted for total energy intake, demographics, lifestyle factors, and waist circumference.

RESULTS

There were 1,026 cases of incident type 2 diabetes during follow-up (11.7%). Adherence to the Southern dietary pattern was most strongly associated with risk of incident type 2 diabetes after adjustment for demographics and lifestyle (quintile [Q]5 vs. lowest Q1: risk ratio [RR] 1.95; 95% CI 1.57, 2.41). Of the diet scores, DIS (Q5 vs. Q1 RR 1.41) and MIND (Q1 vs. Q5 RR 1.33), demonstrated anti-inflammatory diets, had strongest associations with lower diabetes incidence.

CONCLUSIONS

We found associations of several dietary approaches with incident type 2 diabetes. Investigation into mechanisms driving the association with the Southern dietary pattern is warranted. Further research into use of DIS, DII, and MIND diet score should be considered for dietary recommendations for diabetes prevention.
Biobehavioral Changes Following Transition to Automated Insulin Delivery: A Large Real-life Database Analysis
Authors: Kovatchev Boris P. , Singh Harsimran , Mueller Lars , Gonder-Frederick Linda A.
Published: September 2022

OBJECTIVE

To document glycemic and user-initiated bolus changes following transition from predictive low glucose suspend (PLGS) system to automated insulin delivery (AID) system during real-life use.

RESEARCH DESIGN AND METHODS

We conducted analysis of 2,329,166 days (6,381 patient-years) of continuous glucose monitoring (CGM) and insulin therapy data for 19,354 individuals with type 1 Diabetes, during 1-month PLGS use (Basal-IQ technology) followed by 3-month AID use (Control-IQ technology). Baseline characteristics are as follows: 55.4% female, age (median/quartiles/range) 39/19–58/1–92 years, mean ± SD glucose management indicator (GMI) 7.5 ± 0.8. Primary outcome was time in target range (TIR) (70–180 mg/dL). Secondary outcomes included CGM-based glycemic control metrics and frequency of user-initiated boluses.

RESULTS

Compared with PLGS, AID increased TIR on average from 58.4 to 70.5%. GMI and percent time above and below target range improved as well: from 7.5 to 7.1, 39.9 to 28.1%, and 1.66 to 1.46%, respectively; all P values <0.0001. Stratification of outcomes by age and baseline GMI revealed clinically significant differences. Glycemic improvements were most pronounced in those <18 years old (TIR improvement 14.0 percentage points) and those with baseline GMI >8.0 (TIR improvement 13.2 percentage points). User-initiated correction boluses decreased from 2.7 to 1.8 per day, while user-initiated meal boluses remained stable at 3.6 to 3.8 per day.

CONCLUSIONS

Observed in real life of >19,000 individuals with type 1 diabetes, transitions from PLGS to AID resulted in improvement of all glycemic parameters, equivalent to improvements observed in randomized clinical trials, and reduced user-initiated boluses. However, glycemic and behavioral changes with AID use may differ greatly across different demographic and clinical groups.
Traditional and Non-traditional Cardiovascular Risk Factors and Cardiovascular Disease in Women with Psoriasis
Authors: Näslund-Koch Charlotte , Vedel-Krogh Signe , Bojesen Stig Egil , Skov Lone
Published: September 2022

Women with cardiovascular disease are underdiagnos-ed, undertreated and under-represented in research. Even though the increased risk of cardiovascular disease among patients with psoriasis is well establi-shed, only a few studies have examined women with psoriasis. This study examined the prevalence of cardio-vascular risk factors and cardiovascular disease among women with psoriasis. Using the Copenhagen City Heart Study and the Copenhagen General Population Study, 66,420 women were included in a cross-sectional design. Of these, 374 (0.56%) women had hospital-diagnosed psoriasis. Women with vs with-out hospital-diagnosed psoriasis had higher odds ratios of having traditional cardiovascular risk factors, including hypertriglyceridaemia, smoking, obesity, type 2 diabetes, and low physical activity, and of having non-traditional cardiovascular risk factors, including low level of education, high level of psycho-social stress, and low-grade inflammation. Compared with women from the general population, the multi-variable adjusted odds ratio of heart failure and ischaemic cerebrovascular disease in women with hospital-diagnosed psoriasis was 2.51 (95% confidence interval 1.33–4.73) and 2.06 (1.27–3.35). In conclusion, women with hospital-diagnosed psoriasis have a higher prevalence of traditional and non- traditional cardiovascular risk factors, and increased risk of heart failure and ischaemic cerebrovascular disease, even after adjusting for these cardiovascular risk factors.
Fiber laser cutting of steel materials with twin spot beam-twin spot setting in kerf width direction
Authors: Morimoto Kota , Yagi Atsushi , Kai Naoto , Okamoto Yasuhiro , Okada Akira , Ishiguro Hiroaki , Ito Ryohei , Sugiyama Akihiko , Okawa Hiroshi
Published: September 2022

In laser cutting, the temperature distribution would have significant influence on cutting characteristics, and the intensity distribution of a laser beam has a possibility to improve the cutting quality. In this study, a fiber laser beam of Gaussian distribution was divided into two beams by a roof axicon lens, and the cutting characteristics were investigated by using the twin spot Gaussian beam setting in the kerf directions. The cutting experiment of a cold-rolled steel plate with a thickness of 3.2 mm was carried out by a 3 kW fiber laser with a nitrogen assist gas, and the Gaussian mode of 114 μm spot and the twin Gaussian mode of two 110 μm spots were used with the variation of power ratio in twin spot processing. At the exit side of kerf by the twin spot process, the width of the cutting front in the low intensity side became wider than that in the high intensity side, and the dross could be reduced in the low intensity side due to sufficient ejection of the molten metal from the front wall rather than the side wall of kerf. The twin spot process could reduce the dross height below 18 μm in the low intensity side, which is smaller than that by the single Gaussian beam process.
PENGARUH PENGUNGKAPAN CORPORATE SOCIAL RESPONSIBILITY TERHADAP KUALITAS LABA
Authors: Siswantaya I Gede
Published: September 2022

ABSTRACT
This study aims to obtain evidence of the influence of Corporate Social Responsibility (CSR) disclosure on earnings quality. The sample of the study is manufacturing companies listed on the Indonesia Stock Exchange (IDX) during the 2016-2019 period, consisting of 124 companies with 457 observations. Data were obtained from the IDX website and companies’ websites. This study uses multiple regression analysis in testing the hypothesis. The control variables used in this study are leverage, firm size and Return on Assets (ROA). The findings show that Corporate Social Responsibility (CSR) disclosure positively affects earnings quality.
Keywords:       corporate social responsibility disclosure; earnings quality; earnings management; leverage; firm size; return on assets.
 
ABSTRAK
Penelitian ini bertujuan untuk memperoleh bukti empiris mengenai pengaruh pengungkapan Corporate Social Responsibility (CSR) terhadap kualitas laba. Sampel dalam penelitian ini adalah perusahaan manufaktur yang terdaftar di BEI tahun 2016-2019. Berdasarkan kriteria yang ditetapkan terdapat 124 perusahaan dengan 457 pengamatan. Data penelitian diperoleh dari situs resmi Bursa Efek Indonesia (BEI) dan website masing-masing perusahaan. Pengujian hipotesis menggunakan analisis regresi linear berganda. Penelitian ini menggunakan variabel kontrol yaitu leverage, firm size dan Return on Assets (ROA). Hasil penelitian ini menunjukkan bahwa pengungkapan Corporate Social Responsibility (CSR) berpengaruh positif terhadap kualitas laba.
Kata kunci:    pengungkapan corporate social responsibility; kualitas laba; manajemen laba; leverage; firm size; return on assets.
KOMODIFIKASI AGAMA DALAM KONTEN YOUTUBE “UKHTI MEGA OFFICIAL”
Authors: Fiorentina Desika
Published: September 2022

Fenomena adanya media sosial yang sangat di gandrungi saat ini adalah Youtube. Youtube merupakan salah satu platform audio visual sudah ada sejak lama yang mendapat perhatian tersendiri dalam masyarakat, terlebih anak muda yang memiliki ide kreatif dalam membuat konten-konten youtube sehingga konten tersebut menarik minat viewers untuk menontonnya. Kebebasan masyarakat yang dapat berperan sebagai kreator  sekaligus penonton menjadi daya tarik masyarakat khususnya Indonesia untuk menggunakan Youtube. Memiliki akses yang sangat mudah serta beragam konten yang up to date yang disajikan menjadikan Youtube sebagai alternative untuk masyarakat terlebih generasi muda. Konten-konten yang disajikan bisa dalam ekonomi seperti iklan produk, review produk tertentu, dalam bidang pendidikan semisal beasiswa, perjalanan mengembara dalam menuntut ilmu, atau yang lainnya ataupun konten berbasis agama yang berisikan tentang berisi motivasi, ceramah, hijrah, atau konten agama lainnya. Penggunaan media sosial  berdampak  pada peningkatan  perekonomian penggunanya. Para pengguna Youtube atau yang sering dikenal dengan Youtuber bisa menghasilakn pundi-pundi rupiah melalui jumlah likers, subscribers ataupun share.[1]

 

[1] Ferdi Arifin, “Mubaligh Youtube dan Komodifikasi Konten Dakwah”, Jurnal Dakwah dan Komunikasi, Volume 4, Nomor 1, Januari-Juni 2019.
Covid-19 Pandemic: Project-Based Learning as Interprofessional Learning Model to Improve Student With The Special Needs’ Self Efficacy
Authors: Purnomo Halim , Karim Abdul , Mansir Firman , Valero-Matas Jesús Alberto
Published: September 2022

There is a particular emphasis on education for special needs children. They have a right to an education that is appropriate to their needs. This study aimed to improve the self-efficacy of students with special needs who studied in inclusive elementary schools by using project-based learning. The research method used explorative qualitative with the interview, observation, and documentation instruments through triangulation. All instruments were analyzed in-depth, descriptive narrative. This research was carried out in the inclusive elementary schools, among others were five Public Elementary Schools (PES). The findings show that the learning approach of project-based learning at inclusive elementary schools in the covid-19 pandemic effectively improved the students with special need to be active, participatory and feel motivated to solve learning problems experienced by learning products produced.
Modeling of fractional differential equation in cloud computing image fusion algorithm
Authors: Yang Xuefeng , Zeng Jun , Xu Chong , Peng Lin , Alsultan Jamal
Published: September 2022

In order to solve the problems of poor image quality, low definition and loss of image information in traditional algorithms, a modeling research of fractional differential equation in cloud computing image fusion algorithm is proposed. Firstly, the method of image denoising and enhancement under the framework of fractional calculus theory and the improved algorithm based on it are discussed. A series of difficult problems in the image processing method based on fractional calculus are discussed. Then, the large data video image in cloud computing environment is fused in scale space through fractional differential equation, and the fused image is decomposed by lifting fractional differential equation to obtain the low-frequency subband coefficients and high-frequency subband coefficients in different scale space. For the low-frequency subband coefficients and high-frequency subband coefficients, their respective fusion schemes are given to obtain the lifting static small transform coefficients of the fused image. The fusion effect of the proposed algorithm is tested from both subjective and objective aspects.The results show that the entropy value of this algorithm is 7.1450, slightly higher than sparse coding algorithm and random walk algorithm, which shows that the fusion processing by this algorithm will not lose the amount of information contained in the image. Therefore, the image denoising and enhancement algorithm of fractional differential equation proposed in this paper has good subjective fusion effect, good clarity and quality of the fused image, and will not lose the information contained in the image.
Positive politeness strategies during online learning: A cyberpragmatic study
Authors: Kusmanto Hari , Widodo Pratomo
Published: September 2022

Language politeness and character education are crucial in the era of education disruption, particularly in terms of learning communication. Problems with language politeness happen when communication is mediated by electronic media, such as WhatsApp in particular, because it allows undergraduates to be more open in conveying their intentions, including to the lecturers regarding the learning goals. This study aims to describe the forms of language politeness during online learning in higher education. The study used a descriptive qualitative approach. The data of this study were utterances consisting of language politeness, and the data sources were undergraduates’ utterances to their lecturer. The data collection techniques were documenting, reading, and note-taking. The data were analyzed through referential identity, extra lingual interactive model, and politeness strategies proposed by Brown and Levinson (1987) and Maricic (2000). Cyberpragmatic perspective perceives the positive politeness strategies with the help of external context, in this case, the virtual learning context, to find out whether there were positive politeness strategies in the utterances. The findings indicate that positive politeness strategies during online learning using cyberpragmatic approach are represented in six forms: paying attention, using identity markers, looking for agreement, avoiding conflict, creating humor, and showing an optimistic attitude. This study recommends that positive politeness strategies can be used as a pillar of developing and strengthening character education in learning, especially in universities.
The pragmatic study of metafiction in Preeti Shenoy’s ‘The Secret Wish List’ and ‘It Happens for A Reason’
Authors: Pandeeswari D , Hariharasudan A , Hassan Ahdi
Published: September 2022

This study aims to spotlight the postmodern tendency of metafiction in Preeti Shenoy’s selected texts. Metafiction is self-conscious in relation to language, literary form, and storytelling in fiction. This form of fiction accentuates its construct and reminds the readers to be aware of a fictional work. Shenoy is a noteworthy postmodern writer, and her famous novels are ‘The Secret Wish List’ (2012) and ‘It Happens for Reason’ (2014). These two novels exhibit the subject of postmodern metafiction through her writings. In these novels, the protagonists overcome their family doctrines to fulfill their wishes. The method of study adopted the metafiction theories proposed by Mark Currie, Patricia Waugh, and Linda Hutcheon. It highlights Shenoy’s texts that represent the elements of metafiction through the protagonists. Using various theories related to postmodern metafiction, the view of metafiction in the texts is substantiated and explored. The postmodern perspective of metafiction is explored in Shenoy’s texts and analyzed with metafiction theories. The study results are compared and discussed with other studies and contemporary texts concerning metafiction. The findings show that metafiction is applicable in the texts of the two novels by Shenoy. She projects the aspects of metafiction in her works through her writing, especially narration, both fiction and reality.
Erasmus - Biographie
Aus dem Niederländischen übersetzt von Werner Kaegi
Authors: Huizinga Johan
Published: September 2022

Die Biographie des Erasmus von Rotterdam, die Johan Huizinga im Jahr 1924 sowohl auf Englisch als auch auf Niederländisch veröffentlichte, ist ein Klassiker der Geschichtsschreibung. Wie Erasmus in einer instabilen, stets von Kriegen bedrohten Zwischenzeit wirkend, behandelte Huizinga einfühlsam und aufrüttelnd Leben und Werk seines grossen Landsmannes. Die Bedeutung dieser Biographie erkannte früh Werner Kaegi, der an der Universität Leipzig mit einer Arbeit über Hutten und Erasmus promoviert hatte und später jahrzehntelang Geschichte an der Universität Basel lehrte. Er übersetzte das Werk ins Deutsche, um es einer breiten Leserschaft zugänglich zu machen. Die Erstauflage, die hier reproduziert ist, erschien im Jahr 1928 bei Schwabe und ist mit Holz- und Metallschnitten von Hans Holbein dem Jüngeren geschmückt.
Sleep deprivation: A toxicogenic drive for neurodegenerative diseases and public health issue
Authors:   Toxicology Unit, Department of Pharmacology, Faculty of Medicine, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Nigeria, Afonne Onyenmechi Johnson , Ifediba Emeka Chinedu ,   Toxicology Unit, Department of Pharmacology, Faculty of Medicine, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Nigeria, Afonne Anulika Johnson ,   Department of Nursing Science, Faculty of Health Sciences and technology, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Nigeria
Published: September 2022

Sleep deprivation is gradually becoming a common phenomenon in modern societies, especially among chronic users of social media, night shifts workers, students and some less-privileged populations. The erroneous perception among certain subgroups of the population that time spent to sleep is time wasted is of great concern, because sleep is indeed critical for good health and survival. Of greater concern are the effects of alcohol, beverages like caffeine and environmental toxicants like heavy metals and pesticides on normal sleep mechanisms. The consequences of sleep disorder are dire as it alters immune responses and have been reported to increase the risk of some non-communicable diseases. The inter-individual differences in sleep requirements may present a challenge in determining adequate sleep duration. On the average, most adults need about seven to eight hours of sleep each night while teens and children need more. Accumulation of sleep debt for individuals sleeping less than the required sleeping duration may lead to chronic health and behavioural problems. We opine that the mechanisms underlying sleep disruption by some foods and toxicants have toxicogenic link. There is need, therefore, to consider sleep deprivation as a public health issue with a view to ensuring proper advocacy among risk groups in order to improve quality of life and economy of nations. Given the prevalence of alcohol and caffeine consumption, exposures to heavy metals and pesticides, and increasing neurodegenerative disorders, there is need to elucidate the precise mechanisms of sleep disruption and exposures to the aforementioned chemicals.
ANALISIS DATA KUALITATIF: MANUAL ATAU DENGAN APLIKASI?
Authors: Rofiah Chusnul
Published: September 2022

Pesatnya perkembangan komputerisasi metode analisis data untuk penggunaan penyelidikan naturalistik dalam penelitian kualitatif, tujuan dari catatan penelitian ini adalah untuk membandingkan manual dan komputerisasi teknik analisis data. Dengan berbagai macan pertimbangan kelebihan, kekurangan, dan umum dimiliki asumsi penggunaan aplikasi dan secara manual terus berlanjut karena kelangkaan literatur yang membahas keuntungan dan kelemahan kedua metode tersebut. Dan pada dasarnya peneliti dapat menganalis data tanpa menggunakan aplikasi, peneliti senior lebih bebas bekerja tanpa aplikasi. Kemajuan teknologi menyebabkan penelitian tergantung pada teknologi, aplikasi analisis data kualitatif hanya efektif menganalisis data deskriptif. Penggunaan aplikasi hanya efektif pada pendekatan post-positivistik, pada dasarnya analisis data kualitatif lebih efektif dilakukan oleh peneliti sendiri selama ia di lapangan dan saat ia menulis laporan penelitian, kekuatan utama  analisis data kualitatif adalah trianggulasi data dan trianggulasi hasil penelitian.

Aplikasi tidak dapat menganalisis data kualitatif, faktanya bahwa kita telah melihat perkembangan analisis data kualitatif dengan bantuan aplikasi seharusnya tidak mengejutkan mengingat perkembangan yang meluas dan aksesibilitas aplikasi untuk analisis kualitatif data tetap menjadi masalah yang diperdebatkan dan belum digunakan secara universal (R. M. Lee dan Fielding, 1991; Morison dan Moir, 1998). Aplikasi dalam menganalisis data kualitatif dan aturan yang tepat tidak kompatibel dengan sifat data kualitatif yang tidak terstruktur dan ambigu sehingga dapat mendistorsi atau melemahkan data atau melumpuhkan kreativitas (Becker, 1993; Kelle dan Bird, 1995; Richards, 1998). Sifat penelitian kualitatif apabila ditinjau dari volume dan kompleksitas data yang tidak terstruktur dan cara di mana temuan dan teori muncul dari data juga membuat paket perangkat lunak, dikembangkan untuk mengelola dan menganalisis data tersebut, sulit untuk diaplikasikan dan digunakan secara memadai. (Kelle dan Bird, 1995).
Cultura visual y valores. Una crítica al teatro de formato breve
Authors: Ruiz-Ruiz Ingrid , Rosado-Álvarez María
Published: September 2022

La cultura visual constituye un aporte a la reflexión y al desarrollo del pensamiento crítico, sin embargo no siempre es considerada y utilizada como vía para promover valores. Este artículo presenta un acercamiento a este campo de estudio que emerge del teatro de formato breve, con un especial énfasis en el origen de los problemas y sus posibles repercusiones en la sociedad. En esta medida, se hace uso de la metodología cualitativa mediante la observación no participante y análisis de contenido de las diversas propuestas que se ofrecen en la ciudad de Guayaquil, asimismo se apoya en la revisión bibliográfica y documental de los microteatros. Como resultado se obtiene una aproximación al imaginario colectivo y a la capacidad crítica que existe en Guayaquil, entre las conclusiones se destaca que el argot utilizado influye como medio de transmisión cultural que fortalece o destruye los valores de la audiencia que visita estos teatros de formato breve.
Aprendizaje significativo y su relación con la motivación intrínseca, escuela de procedencia y estrategias cognitivas en estudiantes de ingeniería
Authors: Fong-Silva Waldyr , Curiel-Gómez Rebeca , Brito-Carrillo Clara
Published: September 2022

Se analizó la asociación entre el aprendizaje significativo con la motivación intrínseca, escuela de procedencia y estrategias cognitivas en 1200 estudiantes de los programas de ingeniería de Alimentos de la Universidad de Cartagena entre los años 2014 y 2015. El aprendizaje significativo de Ausubel et al. (1991) se midió haciendo uso de un instrumento construido a partir de la escala de aprendizaje estratégico y autorregulatorio de Weinstein and Mayer (1986). La motivación intrínseca y estrategias cognitivas se evaluó con el instrumento diseñado por Lindner et al. (1998) denominado “Inventario de Autorregulación del Aprendizaje” incluyéndole las estrategias de elaboración, organización y repetición de Weinstein y Mayer (1986). La escuela de procedencia se identificó por encuesta. Para el análisis de relación, se cruzaron las variables y se construyeron los diagramas de barra y las tablas de contingencia 2x2 aplicando la prueba de independencia Chi-Cuadrado. Los valores de 0.94 y 0.90 para el alfa de cronbach de los instrumentos escala de aprendizaje estratégico y autorregulatorio de Weinstein and Mayer y el Inventario de Autorregulación del Aprendizaje respectivamente, permitieron validar la consistencia interna de los instrumentos. Los resultados indican que existe un grado de significancia estadística importante (p<0.05) entre el aprendizaje significativo con la motivación intrínseca (p= 0.0000) y las estrategias cognitivas (p=0.0000) a un 95% de nivel de confianza. No se pudo comprobar significancia estadística entre el aprendizaje significativo y la escuela de procedencia de los estudiantes de ingeniería de alimentos.
Clusters and anisotropic turbulence of gas-particle flow in fluidized risers studied using the four-way coupled second-order moment method
Authors: Sun Dan
Published: September 2022

The gas-particle flow in a fluidized bed is characterized as a “core-annulus” pattern with transient clusters moving along the riser. These clusters exist as regions with a higher concentration of particles and are surrounded by dispersed particles at lower concentrations. In this study, clusters and their fluid dynamics were investigated using the four-way coupled second-order moment method of the fluid–particle Eulerian–Eulerian two-fluid model. This model was evidenced in modeling the fluid-particle two phase flow in the previous research, especially when the particles were in medium concentration while the particle turbulence was far from equilibrium to satisfy the Boussinesq approximation. In the simulation, the gas-particle flow in the fluidized risers was predicted. The fluid dynamics of the Geldard B particle clusters in the risers were characterized. In addition, the anisotropic turbulence of either phase in the clusters was studied. According to the turbulence intensity of both the phases, the gas-particle flow in the fluidized riser was classified into six zones. As the volume fraction of the particles increased, the anisotropic ratios of the turbulence intensities in both phases increased in the dispersed zone and decreased in the cluster zone, respectively.
Why the reaction order of biomolecular reaction should be 2.33 instead of 2?
Authors: Chen Jixin
Published: September 2022

Predicting the reaction kinetics, that is, how fast a reaction can happen in a solution, is essential information for many processes, such as industrial chemical manufacturing, refining, synthesis and separation of petroleum products, environmental processes in air and water, biological reactions in cells, biosensing, and drug delivery. Collision theory was originally developed to explain the reaction kinetics of gas reactions with no dilution. For a reaction in a diluted inert gas solution or a diluted liquid solution, diffusion often dominates the collision process. Thus, it is necessary to include diffusion in such a calculation. Traditionally the classical Smoluchowski rate is used as a starting point to predict the collision frequency of two molecules in a diluted solution. In this report, a different collision model is derived from the adsorption of molecules on a flat surface. A surprising result is obtained showing that the reaction order for biomolecular reaction should be 2 and 1/3 instead of 2, following a fractal reaction kinetics.
General Synthetic Entry to Dihydrooxepine-spiroisoxazoline Natural Products: Total Synthesis of Psammaplysin A
Authors: Magauer Thomas , Paciorek Jan , Sokol Kevin , Hoefler Denis , Wurst Klaus
Published: September 2022

Here, we report a general synthetic entry to dihydrooxepine-spiroisoxazoline (DOSI) natural products that culminated in the first total synthesis of psammaplysin A. For the synthesis of the unique spirocyclic fragment we employed a strategy that features two key transformations: (1) The use of a diastereoselective Henry reaction/cyclization sequence granted access to the C7 hydroxylated isoxazoline scaffold in one step. (2) A regioselective Baeyer–Villiger ring expansion enabled selective installation of the fully substituted dihydrooxepine and avoided the risk of a previously observed oxepine-arene oxide rearrangement. The overall synthesis proceeds in 13 steps from inexpensive starting material.
Gold photocatalysis in sustainable hydrogen peroxide generation
Authors: Adnan Rohul , A Jalil Aishah
Published: September 2022

Hydrogen peroxide (H2O2) is a mild and green oxidant widely employed in organic syntheses, medical sector, disinfection, bleaching, environmental remediation and biological processes. However, its production via the expensive, multiple steps and energy intensive anthraquinone process renders it less sustainable. Photocatalysis is a viable, sustainable and promising strategy to produce H2O2 from green sources: water and molecular O2. This article presents the key developments of photocatalytic H2O2 production using gold (Au) nanoparticles supported on semiconductor photocatalysts. Several photocatalytic systems containing Au nanoparticles and the roles of Au nanoparticles in enhancing the photocatalytic H2O2 production including increasing visible light absorption, facilitating the charge carrier separation and transfer, and as a catalytic Au active site are discussed. Factors defining the photocatalytic activity such as the effects of Au particle size and loading, localised surface plasmon resonance, mixed-gold component, and design of photocatalysts are reviewed. Finally, the challenges and prospect for further developments of Au photocatalysis in sustainable H2O2 synthesis are highlighted.
Study of 14N(γ,np)3α Reaction for Eγ up to 150 MeV
Authors: Afanasiev Serhii
Published: September 2022

The reaction 14N(g,np)3a induced by bremsstrahlung photons of endpoint energy Egmax = 150 MeV has been investigated using diffusion chamber, which is placed into the magnetic field. The distribution functions of the reaction yield, the energy and momentum of the final particles from Еg were measured and it was determined that at Еg > 45 MeV, change in the behavior of these functions occurs. The average energy Taver was calculated for the particles with the energy falling within a 1 MeV interval of the total kinetic energy T0 = Eg ‑ Q, where Q is the energy threshold of the reaction (Q = 19.77 MeV). At T0 ~ 20 MeV, the dependence of the contributions from Taver to T0 changes sharply. At T0 > 20 MeV, most of the energy is carried away by nucleons, their relative contribution is equal, and this agrees with the assumption of the quasideuteron interaction mechanism. The momentum distribution distributions for the neutron and proton have a similar form, with a strong shift of the maximum towards higher energies with an increase in the energy of the γ quantum. For a system of 3α‑particles, in each distribution, peak is observed centered at 100 MeV/c, the relative contribution of which smoothly decreases with increasing momentum, and a wide high-energy "tail" appears. The energy and angular correlations of the np‑pair depends on both of the energy Еg and the momentum of the system of 3α‑particles.
Fluorescence Study of the Interactions Between Insulin Amyloid Fibrils and Proteins
Authors: Tarabara Uliana , Zhytniakivska Olga , Vus Kateryna , Trusova Valeriya , Gorbenko Galyna
Published: September 2022

Self-assembly of proteins and peptides into amyloid fibrils is the subject of intense research due to association of this process with multiple human disorders. Despite considerable progress in understanding the nature of amyloid cytotoxicity, the role of cellular components, in particular proteins, in the cytotoxic action of amyloid aggregates is still poorly investigated. The present study was focused on exploring the fibril-protein interactions between the insulin amyloid fibrils and several proteins differing in their structure and physicochemical properties. To this end, the fluorescence spectral properties of the amyloid-sensitive fluorescent phosphonium dye TDV have been measured in the insulin fibrils (InsF) and their mixtures with serum albumin (SA) in its native solution state, lysozyme (Lz) and insulin (Ins) partially unfolded at low pH. It was found that the binding of TDV to the insulin amyloid fibrils is followed by considerable increase of the fluorescence intensity. In the system (InsF + TDV) the TDV fluorescence spectra were decomposed into three spectral components centered at ~ 572 nm, 608 nm and 649 nm. The addition of SA, Lz or Ins to the mixture (InsF + TDV) resulted in the changes of the fluorescence intensity, the maximum position and relative contributions (f1,3) of the first and third spectral components into the overall spectra. The Förster resonance energy transfer between the TDV as a donor and a squaraine dye SQ1 as an acceptor was used to gain further insights into the interaction between the insulin amyloid fibrils and proteins. It was found that the presence of SA do not change the FRET efficiency compared with control system (InsF + chromophores), while the addition of Lz and Ins resulted in the FRET efficiency decrease. The changes in the TDV fluorescence response in the protein-fibril systems were attributed to the probe redistribution between the binding sites located at InsF, the non-fibrillized Ins, SA or Lz and protein-protein interface
Quark-Antiquark Study with Inversely Quadratic Yukawa Potential Using the Nikiforov-Uvarov-Functional-Analysis Method
Authors: Inyang Etido P. , Iwuji Prince C. , Ntibi Joseph E. , Omugbe E. , Ibanga Efiong A. , William Eddy S.
Published: September 2022

The solutions of the Schrödinger equation are obtained with an inversely quadratic Yukawa potential using the Nikiforov-Uvarov-Functional-analysis method. The energy spectrum and wave function were obtained in closed form. The energy equation was used to predict the masses of the heavy mesons such as charmonium (сĉ) and bottomonium (bḃ) for different quantum numbers. The results obtained agreed with other theoretical predictions and experimental data with a percentage error of 1.68 % and 0.50 % for charmonium (сĉ) and bottomonium (bḃ) respectively.