bluuebunny/crossref_metadata_2025 huggingface dataset:
Age Justice
Authors: Burghardt Steve , Dibenedetto Joseph , Sackman Bobbie
Published: March 2022

As baby boomers enter their later years, it has become apparent that ageism is a primary cause of much of the social marginalization and economic inequity experienced by older people. It is thus important to understand that ageism has both structural as well as cultural causes that require collective mobilization to correct. As such, anti-ageism and the fight for age justice fit within the intersectional movements of the 21st century seeking systemic change. This attention to systemic issues of ageism and the call for collective forms of action and organizing have become the foundation for an age justice movement. Therefore, an age justice organizing approach to the problems of older Americans is necessary and its solutions to aging-related problems are similar to solutions in other social justice movements. The historical context of aging and ageism informs present models of age justice organizing and issues addressed in age activism. For example, older workers have experienced workplace discrimination, and in the early COVID-19 pandemic, older people were marginalized. Looking to the future, an age justice framework that consistently addresses ageism as the systemic issue it is can be developed in micro, mezzo, and macro settings for all social workers and the older people with whom they work.
Christine Jorgensen in Cuba
Authors: Lambe Jennifer
Published: March 2022

What should we do with archival dead ends, those enticing finds that never seem to go anywhere? There’s one such lead that I haven’t been able to shake. In 1953, Christine Jorgensen, the world’s first transgender celebrity, traveled to Cuba for a series of performances at the world-famous Tropicana Club. Though the documentary record attached to the trip is sparse, Cubans continued to talk about it, and Jorgensen, for years to come. Here, I reckon with what we do and don’t know about the imprint she left on the island’s sexual culture, especially following the transformations ushered in by the 1959 revolution.
The US Midlife Mortality Crisis Continues: Excess Cause-Specific Mortality During 2020
Authors: Glei Dana A
Published: March 2022

Whether monthly excess mortality in the United States during 2020 varied by age and cause of death is investigated in this analysis. Based on national-level death counts and population estimates for 1999–2020, sex-specific negative binomial regression models were used to estimate monthly cause-specific excess mortality by age group during 2020. Among men, 71% non-COVID excess deaths occurred at working ages (25–64 years), but those ages accounted for only 36% of non-COVID excess deaths among women. Many excess deaths resulted from external causes (particularly among men), heart disease, diabetes, Alzheimer disease (particularly among women), and cerebrovascular disease. For men, the largest share of non-COVID excess deaths resulted from external causes, nearly 80% of which occurred at working ages. Although incorrectly classified COVID-19 deaths may explain some excess non-COVID mortality, misclassification is unlikely to explain the increase in external causes of death. Auxiliary analyses suggested that drug-related deaths may be driving the increase in external mortality, but drug overdoses were already increasing for a full year before the pandemic. The oldest Americans bore the brunt of COVID-19 deaths, but working-age Americans, particularly men, suffered substantial numbers of excess non-COVID deaths, most commonly from external causes and heart disease.
Computational approaches for direct cell reprogramming: from the bulk omics era to the single cell era
Authors: Tran Andy , Yang Pengyi , Yang Jean Y H , Ormerod John
Published: March 2022

Recent advances in direct cell reprogramming have made possible the conversion of one cell type to another cell type, offering a potential cell-based treatment to many major diseases. Despite much attention, substantial roadblocks remain including the inefficiency in the proportion of reprogrammed cells of current experiments, and the requirement of a significant amount of time and resources. To this end, several computational algorithms have been developed with the goal of guiding the hypotheses to be experimentally validated. These approaches can be broadly categorized into two main types: transcription factor identification methods which aim to identify candidate transcription factors for a desired cell conversion, and transcription factor perturbation methods which aim to simulate the effect of a transcription factor perturbation on a cell state. The transcription factor perturbation methods can be broken down into Boolean networks, dynamical systems and regression models. We summarize the contributions and limitations of each method and discuss the innovation that single cell technologies are bringing to these approaches and we provide a perspective on the future direction of this field.
Glomerulonephritis with non-Randall-type, non-cryoglobulinaemic monoclonal immunoglobulin G deposits (PGNMID and ITG)
Authors: Fourdinier Ophélie , Ulrich Marc , Karras Alexandre , Olagne Jérôme , Buob David , Audard Vincent , Vigneau Cécile , Gibier Jean-Baptiste , Guerrot Dominique , Massy Ziad , Vuiblet Vincent , Rabot Nolwenn , Goujon Jean-Michel , Cordonnier Carole , Choukroun Gabriel , Titeca-Beauport Dimitri
Published: March 2022

Background

Glomerulonephritis (GN) with non-Randall-type, non-cryoglobulinaemic monoclonal immunoglobulin G deposits encompasses rare diseases [proliferative GN with non-organized deposits (PGNMID) and immunotactoid GN] that cannot be distinguished without ultrastructural analysis by electron microscopy (EM).

Methods

Here, we report and analyse the prognosis of 41 EM-proven (PGNMID for 39/41) and 22 non-EM-proven/DNAJB9-negative cases, diagnosed between 2001 and 2019 in 12 French nephrology centres.

Results

Median (interquartile range) serum creatinine (SCr) at presentation was 150 (92–256) µmol/L. The predominant histological pattern was membranoproliferative GN (79%), with IgG3 (74%) kappa (78%) deposits the most frequently observed. Disease presentation and patient management were similar between EM-proven and non-EM-proven cases. A serum monoclonal spike was detected for 21 patients and 10 had an underlying haematological malignancy. First-line therapy was mixed between clone-targeted therapy (n = 33), corticosteroids (n = 9) and RAAS inhibitors (n = 19). After 6 months, nine patients achieved complete and 23 partial renal recovery. In univariate analysis, renal recovery was associated with baseline SCr (odds ratio 0.70, P = 0.07). After a median follow-up of 52 (35–74) months, 38% of patients had progressed to end-stage kidney disease independently associated with baseline SCr [hazard ratio (HR) 1.41, P = 0.003] and glomerular crescentic proliferation (HR 4.38, P = 0.004).

Conclusions

Our results confirm that non-cryoglobulinaemic and non-Randall GN with monoclonal IgG deposits are rarely associated with haematological malignancy. The prognosis is uncertain but may be improved by early introduction of a specific therapy.
Gambling Domain Name Recognition via Certificate and Textual Analysis
Authors: Sun GuoYing , Ye Feng , Chai Tingting , Zhang Zhaoxin , Tong Xiaojun , Prasad Shitala
Published: March 2022

On-line gambling is the key illegal behaviour of public security department in most countries due to the potential threat to cyberspace security and social stability. Hence, the research on gambling domain names (GDN) classification is quite important and in great demand for academia and industry. Till now, there is very little research work on this topic. Most of the GDN training datasets in previous work were chosen from GDN blacklists provided by publicly available data sources, and the authors did not verify the authenticity and accuracy of these datasets, and the classification results are not particularly satisfactory. In this paper, certificated and textual analysis-based classification method CT-GDNC is proposed to get GDN training data set with an accuracy of 0.9776 and significantly improve the classification results of GDN. The exhaustive comparative experiments on 10K GDN obtained via Bert fine-tuning model and 10K benign data collected from Alex Top 1 million list show that the proposed method achieves new baseline result for GDN classification with classification accuracy 0.9936, precision 0.9936, F1 0.9936 and recall 0.9939.
Refugees and International Networks after the Fall of Constantinople, 1453–1475
Authors: Harris Jonathan
Published: March 2022

This article will investigate the extent to which the contacts made by Byzantine envoys to western Europe from 1394 onwards were later used by them and by their families to secure a safe haven following the fall of Constantinople in 1453. It will examine first the case of Italy and some examples which have been addressed by previous scholarship, as well as one less well documented case. It will then consider whether the same link between envoys and refugees can be discerned in other western countries, taking England as a case-study. Byzantine envoys were active there from 1398 and there is also plenty of evidence for the presence of refugees from 1455. The envoys apparently enjoyed very cordial relations with the English court which in turn led to a romanticised view of England in Byzantine literary circles as a place of safety. An attempt will then be made to identify individuals at the English court who might have had contact with the envoys, focusing on the Neville family. Two members of this family were in positions of influence at the time when the Byzantine delegations were in the country, while another was later the patron of a number of refugees. The article will then assess whether the earlier contact with the family could have been a factor in motivating refugees to travel to England, as well as considering other explanations.
Trust and translanguaging in English-medium instruction
Authors: Williams Dylan G
Published: March 2022

This study investigated students’ perceptions towards translanguaging in their English-medium instruction (EMI) experiences to understand how it affects their access to the subject content. The focus is on EMI at a leading, research-intensive university in South Korea, qualitatively explored using data collected from interviews with ten undergraduate students, and analysed using the principles of constructivist grounded theory. The emerging theory indicates that students’ experiences of ‘monolingually framed’ shifts between L1 and L2 systems can be understood using the notion of ‘trust’ and that trust reinforces binary choices, in particular EMI situations, of using either the L1 or the L2 system. Further discussion indicates that, over time, these patterns of trust may constrain learning. The study suggests that instilling a competence of translanguaging in students will help them overcome these constraints. Pedagogic implications are discussed for ELT practitioners who prepare students for EMI and/or support EMI content instructors in their teaching practices.
Perspectives on barriers and facilitators to lifestyle change after cardiac events among patients in Saudi Arabia: a qualitative study
Authors: Tunsi Afnan , Chandler Colin , Holloway Aisha
Published: March 2022

Aims

Lifestyle interventions are an essential element in the prevention of cardiovascular disease. However, promoting a healthy lifestyle is challenging because a multitude of factors interact and influence people’s decisions to adopt and maintain healthy lifestyles. The effects of these factors on Saudi cardiac patients are largely unknown. This study aimed to explore the barriers and facilitators to healthy lifestyle changes among Saudis after cardiac events.

Methods and results

The study followed an exploratory qualitative research design, using a social ecological approach. Semi-structured interviews were conducted with 21 participants (13 men and 8 women) who had a cardiac event. Participants were purposively recruited from cardiac clinics of two hospitals in Jeddah, Saudi Arabia. Data were analysed using the qualitative framework analysis, and factors were identified as salient based on their frequency and the potential strength of their impact. Six factors were identified as influencing lifestyle behaviours in cardiac patients, categorized as ‘major’ factors and ‘mediating’ factors. The ‘major’ factors were sociocultural norms, family values, and religious beliefs, and the mediating factors were insufficient healthcare services, physical environment, and policy regulations. Depending upon the behaviours reported and the context, the same factor could be classified as both a barrier and a facilitator.

Conclusion

The findings of this study can be used to inform the development of contextual-based interventions to promote the adoption of healthy lifestyles that meet the population needs and are relevant to Saudi society.
COVID-19 and Psychological Distress: Racial Differences Among Middle-Aged and Older Adults
Authors: Hamler Tyrone C , Nguyen Ann W , Mouzon Dawne M , Taylor Harry O , Qin Weidi , Cobb Ryon J
Published: March 2022

Background and Objectives

COVID-19 has disproportionately impacted older adults and Black individuals. Research has focused on physical outcomes, with less attention to the psychological effects of COVID-19. The objective of this study was to examine the interplay between perceptions of the COVID-19 outbreak as a threat to one’s day-to-day life, race, and psychological distress among middle-aged and older men and women.

Research Design and Methods

Analyses were conducted on a subsample of self-identified non-Latino Whites and Black individuals aged 50 and older (N = 3,834) from the American Trends Panel. Psychological distress was assessed with 5 items adapted from the Center for Epidemiologic Studies Depression Scale and Generalized Anxiety Disorder-7. Perceived COVID-19 day-to-day threat was assessed with a single question. Negative binomial regressions tested the study aim.

Results

Perceptions of COVID-19 day-to-day threat were positively associated with psychological distress. Black individuals reported lower distress than Whites. Regardless of gender, greater perceptions of COVID-19 day-to-day threats were associated with greater distress among both White respondents and Black respondents. However, this association was weaker among Black respondents than White respondents. Among men only, the association between COVID-19 day-to-day threat and distress varied by race, patterned similarly to the race differences identified in the total sample. This association did not vary by race among women.

Discussion and Implications

This study contributes to the emerging literature focused on older adults and COVID-19 related stressors and psychological distress. An intersectional lens shows how structural oppression may shape perceptions of the pandemic. Future work should consider coexisting intersections in marginalized identities and mental health during COVID-19.
A combinatorial approach increases SMN level in SMA model mice
Authors: Dumas Samantha A , Villalón Eric , Bergman Elizabeth M , Wilson Kenneth J , Marugan Juan J , Lorson Christian L , Burnett Barrington G
Published: March 2022

Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by reduced expression of the survival motor neuron (SMN) protein. Current disease-modifying therapies increase SMN levels and dramatically improve survival and motor function of SMA patients. Nevertheless, current treatments are not cures and autopsy data suggest that SMN induction is variable. Our group and others have shown that combinatorial approaches that target different modalities can improve outcomes in rodent models of SMA. Here we explore if slowing SMN protein degradation and correcting SMN splicing defects could synergistically increase SMN production and improve the SMA phenotype in model mice. We show that co-administering ML372, which inhibits SMN ubiquitination, with an SMN-modifying antisense oligonucleotide (ASO) increases SMN production in SMA cells and model mice. In addition, we observed improved spinal cord, neuromuscular junction and muscle pathology when ML372 and the ASO were administered in combination. Importantly, the combinatorial approach resulted in increased motor function and extended survival of SMA mice. Our results demonstrate that a combination of treatment modalities synergistically increases SMN levels and improves pathophysiology of SMA model mice over individual treatment.
Effects of Constant and Fluctuating Temperatures on Gene Expression During Gonadal Development
Authors: Breitenbach Anthony T , Bowden Rachel M , Paitz Ryan T
Published: March 2022

Synopsis

There is ample research demonstrating that temperature can have complex effects on biological processes, including the timing of when organisms respond to temperature; some responses occur rapidly while others require an extended exposure time. However, most of what we know about temperature effects comes from studies using constant temperature conditions, which are not reflective of natural, fluctuating temperatures. Species with temperature-dependent sex determination (TSD) present an ideal system to study the temporal aspects of the temperature response because prior research has established a number of temperature-responsive genes involved in TSD, albeit under constant temperatures. To investigate potential differences in timing of sexual development between constant and fluctuating incubation temperatures, we exposed Trachemys scripta embryos to two conditions that produce males (constant 26°C and 26 ± 3°C) and two that produce females (constant 31°C and 31 ± 3°C), and sampled embryonic gonads for gene expression analysisvia qPCR. We analyzed three genes involved in testis differentiation (Kdm6b,Dmrt1, andSox9) and two genes involved in ovary differentiation (Foxl2andCyp19A1). Results show that Kdm6b expression was significantly lower under fluctuating temperatures compared to constant temperatures. Foxl2 and Cyp19A1 expression were also lower under fluctuating temperatures, but not at all stages of development. These results suggest that constant temperatures caused increases in both Foxl2 and Cyp19A1 expression earlier (developmental stage 20) than fluctuating temperatures (stages 22 and 23). Dmrt1 and Sox9 expression did not differ between constant and fluctuating temperatures. These results highlight that not all genes in a temperature-dependent process respond to temperature in the same manner. Whether there are functional consequences of this variation remains to be determined.
Submarket emergence, customer base expansion and strategic entry timing in the evolution of the German farm tractor industry
Authors: Buenstorf Guido , Guenther Christina , Wilfling Sebastian
Published: March 2022

Technological discontinuities create new submarkets in existing industries, which may favor incumbents or provide opportunities to new entrants. Complementing prior research on the emergence of integrative submarkets that leave the industry’s customer base unchanged, we introduce the notion of additive submarkets, which are characterized by enlarging the focal industry’s customer base and its heterogeneity. Our empirical analysis focuses on how the emergence of an additive submarket after a competence-destroying technological discontinuity affected entry and firm survival in the historical German farm tractor industry. Using propensity score-weighted hazard models to control for the endogeneity of entry timing, we find that diversifying entrants from customer-related industries were more likely to enter and survive after the submarket emerged. We develop a conceptual framework to structure the implications for entry and survival of various types of entrants when technological discontinuities create new integrative or additive submarkets.
Impella support as a bridge to heart surgery in patients with cardiogenic shock
Authors: Saito Shunsuke , Shibasaki Ikuko , Matsuoka Taiki , Niitsuma Ken , Hirota Shotaro , Kanno Yasuyuki , Kanazawa Yuta , Tezuka Masahiro , Takei Yusuke , Tsuchiya Go , Konishi Taisuke , Ogata Koji , Fukuda Hirotsugu
Published: March 2022

OBJECTIVES

In patients with cardiogenic shock, delayed surgery after stabilization of haemodynamics and improvement in end-organ function by mechanical circulatory support is known to yield better outcomes than emergency surgery. We aimed to investigate the effectiveness of Impella (Abiomed, Danvers, MA, USA) as a bridge to cardiac surgery in patients with cardiogenic shock.

METHODS

We reviewed 7 patients with cardiogenic shock who underwent Impella support as a bridge to cardiac surgery using cardiopulmonary bypass at our institution between April 2018 and August 2021.

RESULTS

Cardiogenic shock was caused by ventricular septal rupture in 3 patients, papillary muscle rupture in 1 and acute myocardial infarction in 3. Cardiac surgery was delayed by 1–7 (3.9 ± 2.5) days with Impella support after the diagnosis of cardiogenic shock, during which the hepatic and renal function of the patients improved significantly. Device-related or operation-related adverse events included re-exploration for bleeding in 3 patients, acute limb ischaemia due to thromboembolism in 1 and intraoperative aortic dissection in 1. Thirty-day mortality was 14.3%, and the cumulative survival was 71.4% at 1 year. The survival tended to be better than that in historical control group in which extracorporeal membrane oxygenation was used as a bridge to surgery (P = 0.0992).

CONCLUSIONS

Impella is an effective tool for bridging patients with cardiogenic shock to surgery. This strategy may improve surgical outcomes in patients with cardiogenic shock. However, prolonged Impella support may increase significant adverse events, and further investigation is required to determine the optimal duration of support before surgery.
Sharp concentration inequalities for the centred relative entropy
Authors: Bhatt Alankrita , Pensia Ankit
Published: March 2022

We study the relative entropy between the empirical estimate of a discrete distribution and the true underlying distribution. If the minimum value of the probability mass function exceeds an $\alpha> 0$ (i.e. when the true underlying distribution is bounded sufficiently away from the boundary of the simplex), we prove an upper bound on the moment generating function of the centred relative entropy that matches (up to logarithmic factors in the alphabet size and $\alpha $) the optimal asymptotic rates, subsequently leading to a sharp concentration inequality for the centred relative entropy. As a corollary of this result we also obtain confidence intervals and moment bounds for the centred relative entropy that are sharp up to logarithmic factors in the alphabet size and $\alpha $.
Recognizing and responding to clinical deterioration in adult patients in isolation precautions for infection control: a retrospective cohort study
Authors: Berry Debra , Street Maryann , Hall Kylie , Sprogis Stephanie K , Considine Julie
Published: March 2022

Background

Patient isolation is widely used as a strategy for prevention and control of infection but may have unintended consequences for patients. Early recognition and response to acute deterioration is an essential component of safe, quality patient care and has not been explored for patients in isolation.

Objective

The primary aims of this study were to (i) describe the timing, frequency and nature of clinical deterioration during hospital admission for patients with isolation precautions for infection control and (ii) compare the characteristics of patients who did and did not deteriorate during their initial period of isolation precautions for infection control.

Methods

This retrospective cohort study was conducted across three sites of a large Australian health service. The study sample were adult patients (≥18 years) admitted into isolation precautions within 24 h of admission from 1 July 2019 to 31 December 2019.

Results

There were 634 patients who fulfilled the study inclusion criteria. One in eight patients experienced at least one episode of clinical deterioration during their time in isolation with most episodes of deterioration occurring within the first 2 days of admission. Timely Medical Emergency Team calls occurred in almost half the episodes of deterioration; however, the same proportion (47.2%) of deterioration episodes resulted in no Medical Emergency Team activation (afferent limb failure). In the 24 h preceding each episode of clinical deterioration (n = 180), 81.6% (n = 147) of episodes were preceded by vital signs fulfilling pre-Medical Emergency Team criteria. Patients who deteriorated during isolation for infection control were older (median age 74.0 vs 71.0 years, P = 0.042); more likely to live in a residential care facility (21.0% vs 7.2%, P = 0.006); had a longer initial period of isolation (4.0 vs 2.9 days, P = < 000.1) and hospital length-of-stay (median 4.9 vs 3.2 days, P = < 0.001) and were more likely to die in hospital (12.3% vs 4.3%, P < 0.001).

Conclusion

Patients in isolation precautions experienced high Medical Emergency Team afferent limb failure and most fulfilled pre-Medical Emergency Team criteria in the 24 h preceding episodes of deterioration. Timely recognition and response to clinical deterioration continue to be essential in providing safe, quality patient care regardless of the hospital-care environment.
Statistical trajectory-distance metric for nautical route clustering analysis using cross-track distance
Authors: Yoo Wonchul , Kim Tae-wan
Published: March 2022

This study presents a novel statistical trajectory-distance metric specialized for nautical route clustering analysis. Based on the dynamic time warping (DTW) metric, one of the most used metrics for trajectory-distance, the statistical trajectory-distance metric was defined by replacing the distance term in DTW with a linear combination of the Jensen–Shannon divergence and Wasserstein distance. Each waypoint from a nautical route was modelled as a discrete and asymmetric binomial normal distribution defined by the cross-track distance (XTD) of the waypoint. The model was then used to compute the statistical distance between waypoints. Nautical route clustering was performed using density-based spatial clustering of applications with noise and the statistical trajectory-distance metric. The nautical route for the clustering analysis, including the XTD information, was extracted from automatic identification system data from the southern sea of the Korean Peninsula. The clustering results were evaluated by comparing them with the results of other popular trajectory-distance metrics. The proposed method was more effective compared to other trajectory-distance when the trajectories pass on both sides of a small island, which is frequent case in coastal route clustering.
Reevaluation of the phylogenetic relationships among Neotomini rodents (Hodomys, Neotoma, and Xenomys) and comments on the woodrat classification
Authors: Bradley Robert D , Edwards Cody W , Lindsey Laramie L , Bateman Joanna R , Cajimat Maria N B , Milazzo Mary L , Fulhorst Charles F , Matocq Marjorie D , Mauldin Matthew R
Published: March 2022

The woodrats or packrats of the genus Neotoma have been the subject of a wide array of research including paleoecology, physiology, morphological evolution, systematics, speciation, and hybridization. In recent years, much work has been done to elucidate evolutionary relationships within and between closely related species of the genus; in particular the addition of newly collected specimens from critical geographic regions has provided new opportunities for taxonomic assessment. Given these new data and their potential, parsimony (PARS), maximum likelihood (ML), and Bayesian inference (BI) analyses were conducted on DNA sequences obtained from nine individual genes (four mitochondrial loci: 12S, 16S, CoII, and Cytb; five nuclear loci: AdhI2, BfibI7, En2, Mlr, and Myh6) to estimate the phylogenetic relationships among 23 species of Neotoma. Results of these analyses depicted a wide array of phylogenetic relationships among taxa; with substantial nodal support recovered in both the ML and PARS analyses at some mid-level and terminal positions. Several individual genes, particularly 12S, AdhI2, BfibI7, CoII, and Cytb, provided support at several basal positions; however, phylogenetic resolution was limited in the other genes. A final BI analysis where the nine genes were concatenated into a single data set produced several supported clades that corresponded to previously recognized species groups (floridana, micropus, mexicana, and lepida) and the subgenus Homodontomys. Levels of genetic divergence for within-species comparisons (estimated from the Cytb data set) ranged from 0.88% (N. magister) to 6.82% (N. fuscipes); for between sister species comparisons ranged from 4.68% (N. devia and N. lepida) to 12.70% (N. angustapalata and N. nelsoni); and for members within closely related clades ranged from 8.70% (N. bryanti and N. lepida) to 12.57% (N. goldmani and N. magister). Evaluations of generic, subgeneric, and species group boundaries were explored using phylogenetic principles on the DNA sequence data presented herein, as well as morphological findings from previous studies. Results obtained suggest that the most conservative taxonomic interpretation involves the abandonment of subgeneric delineations and relies on the recognition of eight species groups (cinerea, floridana, fuscipes, lepida, mexicana, micropus, phenax, and stephensi) as the backbone of the woodrat classification.
Research on the Economics of Cancer-Related Health Care: An Overview of the Review Literature
Authors: Davidoff Amy J , Akif Kaitlin , Halpern Michael T
Published: March 2022

We reviewed current literature reviews regarding economics of cancer-related health care to identify focus areas and gaps. We searched PubMed for systematic and other reviews with the Medical Subject Headings “neoplasms” and “economics” published between January 1, 2010, and April 1, 2020, identifying 164 reviews. Review characteristics were abstracted and described. The majority (70.7%) of reviews focused on cost-effectiveness or cost-utility analyses. Few reviews addressed other types of cancer health economic studies. More than two-thirds of the reviews examined cancer treatments, followed by screening (15.9%) and survivorship or end-of-life (13.4%). The plurality of reviews (28.7%) cut across cancer site, followed by breast (20.7%), colorectal (11.6%), and gynecologic (8.5%) cancers. Specific topics addressed cancer screening modalities, novel therapies, pain management, or exercise interventions during survivorship. The results indicate that reviews do not regularly cover other phases of care or topics including financial hardship, policy, and measurement and methods.
Using intraspecific variation of functional traits and environmental factors to understand the formation of nestedness patterns of a local forest community
Authors: Wang Weitao , Jiang Yun , Chen Yongfa , Luo Wenqi , He Dong , Wang Youshi , Chu Chengjin , Li Buhang
Published: March 2022

The concept of nestedness originated from the field of biogeography decades ago and has been widely used in metacommunities and biological interaction networks, but there is still a lack of research within local communities. Moreover, studies on nestedness usually rarely incorporate the functional traits of the species and the environmental characteristics of the sites. In this study, we constructed a species presence–absence matrix of a 50-ha forest plot, used the simulated annealing algorithm to reveal the maximum nested structure and further tested the significance of nestedness patterns by constructing null ensembles. The nested ranks were used to represent the orders of species and quadrats in the maximum nestedness matrix. The regression tree analysis was used to reveal the relationships of nested ranks with environmental factors and functional traits. We found that the co-occurrence pattern of local plant communities was significantly nested. The regression tree results showed that the nested ranks of quadrats were determined by soil available phosphorus, soil water content, soil organic carbon and soil pH. Intraspecific variation of functional traits, including leaf C, leaf pH, leaf dry matter content and maximum photosynthetic rate rather than means of functional traits, provided a better explanation for the formation of species’ nested ranks. Understanding the causes of species and quadrats nested ranks provides novel lens and useful insights into ecological processes underlying nestedness, and further improves our knowledge of how local plant communities are assembled.
Species-specific growth, morphological and physiological responses ofAbies faxonianaandPicea purpureaunder elevated temperature and CO2
Authors: Dong Haojie , Huang Zongdi , Li Wen , Yu Lei
Published: March 2022

Although many studies have evaluated plant ecophysiological responses to increasing atmospheric carbon dioxide concentration (CO2) and increasing temperature, few studies have addressed the interactive effects of these two factors, especially on high-altitude trees that are more sensitive. To address this issue, we used Abies faxoniana and Picea purpurea seedlings to evaluate the effects of elevated CO2 (CeTa, 700 ppm), elevated temperature (CaTe, 2 °C above ambient temperature) and elevated CO2 combined with elevated temperature (CeTe) on plant growth, morphology and physiological responses. We found that CaTe increased conifer total dry mass, specific root length, net photosynthesis rate and translocation rates of 15NH4+ and 15NO3−, but CeTe had stronger responses (except net photosynthesis rate of A. faxoniana). These results indicate that the effect of elevated temperature on the growth and physiological responses is enhanced by elevated CO2. Furthermore, effect of CeTe on physiological traits was higher in P. purpurea, which possessed a higher total dry mass, specific leaf area, water use efficiency (δ 13C), δ 15NO3−-N level, translocation rates of 15NH4+ and 15NO3− and total nonstructural carbohydrates than A. faxoniana. Overall, these findings suggest that the interactive effects of CO2 × temperature should be considered when assessing conifer responses to future climates.
Pulse oximeters market analysis during the COVID-19 pandemic: Kyiv pharmacies’ offers and survey of pharmacy faculty students
Authors: Brytanova Tetiana , Maletsky Mykola , Lysianska Hanna , Antypenko Lyudmyla
Published: March 2022

Objectives

The objective of this study was to study the market of pulse oximeters to select the optimal choice for monitoring health status during the COVID-19 pandemic.

Methods

Pulse oximeter data, presented on the Tabletki.ua website (2021) in Kyiv (Ukraine), were summarized and discussed. A survey about the history of the device purchase among 170 students of the Faculty of Pharmacy (Zaporizhzhia State Medical University, Ukraine) was statistically analysed by Kolmogorov–Smirnov, Shapiro–Wilk, Levene’s, Scheffe tests, one-sample t-test, Spearman’s correlation and one-way ANOVA.

Key findings

The largest part of the Kyiv (Ukraine) pulse oximeter market is occupied by the People’s Republic of China (70.97%). The price ranged from UAH 171.50 to UAH 1799.00. The models S6 and Linke LK88 are found to be the best choices according to the fullest provided data, the lowest minimum price and emphasis on the oxygen saturation and pulse rate accuracies. Medical students statistically significant would buy a pulse oximeter for less than UAH 563.40 (t(76) = −2.884; P = 0.005). The price did not depend on age (F = 1.104, P = 0.372) or gender (F = 2.466, P = 0.121), but there was a correlation between price and year of purchase (F = 2.712, P = 0.051). Students are primarily interested in country of origin, guarantees and pharmacist recommendations. A significantly weak Spearman’s correlation was found between price and friend advice (ρ = 0.275, Sig. = 0.015).

Conclusions

The same models differ in price by up to 4.2 times and in between them – up to 10. Less than half of the responders bought devices, and even a quarter of them did not use them at all, although they were from a health field. The detailed notifications about accuracy for different patient skin types are required in the device description. More people should be aware of pulse oximeter importance to maintaining health after COVID-19.
Aortic valve surgery for native valve endocarditis in extreme obesity
Authors: Mohamed Saifullah , Patel Akshay J , Subramanian Ajay , Abdelaziz Mahmoud , Nikolaidis Nicholas
Published: March 2022

Surgical aortic valve replacement represents a class one indication in the setting of aortic valve endocarditis and decompensated heart failure secondary to aortic regurgitation as per the European Society of Cardiology. However, extreme obesity, whereby the body mass index (BMI) >40 kg/m2, represents a challenging cohort of patients. Performing cardiac surgery in the bariatric population is fraught with challenges pertaining to intraoperative issues of surgical access and approach. We describe the case of a 45-year-old gentleman who had previous been diagnosed with infective endocarditis of the aortic valve and with a BMI of 68.2 (228 kg). Surgical aortic valve replacement in extreme obesity is associated with deep sternal wound infection, requirement and duration of mechanical ventilation, atrial fibrillation and renal failure. The ‘obesity paradox’ of overweight and class I obesity (BMI <35) has demonstrated favourable long-term results compared with underweight patients or even those with normal BMI undergoing cardiac surgery.
Angular momentum analysis in the elliptic restricted three-body problem
Authors: Qi Yi , Qiao Dong
Published: March 2022

In this paper, the angular momentum of the test particle during the flyby in the spatial elliptic restricted three-body problem (ERTBP) is investigated. We focus on the flyby around the small primary, and derive approximate expressions to depict the changes of the angular momentum and energy in this process. Numerical computation based on the Earth–Moon ERTBP shows that our expressions can well approximate the real angular momentum and energy processes during the flyby. Hence, the mechanical process of a flyby orbit in the ERTBP is uncovered in detail. Furthermore, we analyse the optimal regions to maximize the changes of the angular momentum and energy. In addition, the inclination of the test particle during the flyby is investigated through the approximate expression of the angular momentum. The optimal flyby condition to change the inclination is obtained and discussed.
MOMO – V. Effelsberg, Swift, and Fermi study of the blazar and supermassive binary black hole candidate OJ 287 in a period of high activity
Authors: Komossa S , Grupe D , Kraus A , Gonzalez A , Gallo L C , Valtonen M J , Laine S , Krichbaum T P , Gurwell M A , Gómez J L , Ciprini S , Myserlis I , Bach U
Published: March 2022

We report results from our ongoing project MOMO (Multiwavelength Observations and Modelling of OJ 287). In this latest publication of a sequence, we combine our Swift UVOT–XRT and Effelsberg radio data (2.6–44 GHz) between 2019 and 2022.04 with public SMA data and gamma-ray data from the Fermi satellite. The observational epoch covers OJ 287 in a high state of activity from radio to X-rays. The epoch also covers two major events predicted by the binary supermassive black hole (SMBH) model of OJ 287. Spectral and timing analyses clearly establish: a new UV–optical minimum state in 2021 December at an epoch where the secondary SMBH is predicted to cross the disc surrounding the primary SMBH; an overall low level of gamma-ray activity in comparison to pre-2017 epochs; the presence of a remarkable, long-lasting UV–optical flare event of intermediate amplitude in 2020–2021; a high level of activity in the radio band with multiple flares; and particularly a bright, ongoing radio flare peaking in 2021 November that may be associated with a gamma-ray flare, the strongest in 6 yr. Several explanations for the UV–optical minimum state are explored, including the possibility that a secondary SMBH launches a temporary jet, but the observations are best explained by variability associated with the main jet.
Stress-testing cosmic ray physics: the impact of cosmic rays on the surviving disc of ram-pressure-stripped galaxies
Authors: Farber Ryan J , Ruszkowski Mateusz , Tonnesen Stephanie , Holguin Francisco
Published: March 2022

Cluster spiral galaxies suffer catastrophic losses of the cool, neutral gas component of their interstellar medium due to ram pressure stripping, contributing to the observed quenching of star formation in the disc compared to galaxies in lower density environments. However, the short-term effects of ram pressure on the star formation rate and active galactic nucleus (AGN) activity of galaxies undergoing stripping remain unclear. Numerical studies have recently demonstrated cosmic rays can dramatically influence galaxy evolution for isolated galaxies, yet their influence on ram pressure stripping remains poorly constrained. We perform the first cosmic ray magnetohydrodynamic simulations of an L* galaxy undergoing ram pressure stripping, including radiative cooling, self-gravity of the gas, star formation, and stellar feedback. We find the microscopic transport of cosmic rays plays a key role in modulating the star formation enhancement experienced by spirals at the outskirts of clusters compared to isolated spirals. Moreover, we find that galaxies undergoing ram pressure stripping exhibit enhanced gas accretion on to their centres, which may explain the prevalence of AGNs in these objects. In agreement with observations, we find cosmic rays significantly boost the global radio emission of cluster spirals. Although the gas removal rate is relatively insensitive to cosmic ray physics, we find that cosmic rays significantly modify the phase distribution of the remaining gas disc. These results suggest observations of galaxies undergoing ram pressure stripping may place novel constraints on cosmic ray calorimetry and transport.
The evolution of the barred galaxy population in the TNG50 simulation
Authors: Rosas-Guevara Yetli , Bonoli Silvia , Dotti Massimo , Izquierdo-Villalba David , Lupi Alessandro , Zana Tommaso , Bonetti Matteo , Nelson Dylan , Springel Volker , Hernquist Lars , Vogelsberger Mark
Published: March 2022

We use the magnetic-hydrodynamical simulation TNG50 to study the evolution of barred massive disc galaxies. Massive spiral galaxies are already present as early as z = 4, and bar formation takes place already at those early times. The bars grow longer and stronger as the host galaxies evolve, with the bar sizes increasing at a pace similar to that of the disc scalelengths. The bar fraction mildly evolves with redshift for galaxies with $M_{*}\ge 10^{10}\rm M_{\odot }$, being greater than $\sim 40{{\ \rm per\ cent}}$ at 0.5 < z < 3 and $\sim 30{{\ \rm per\ cent}}$ at z = 0. When bars larger than a given physical size ($\ge 2\, \rm kpc$) or the angular resolution limit of twice the I-band angular PSF FWHM of the HST are considered, the bar fraction dramatically decreases with increasing redshift, reconciling the theoretical predictions with observational data. We find that barred galaxies have an older stellar population, lower gas fractions, and star formation rates than unbarred galaxies. In most cases, the discs of barred galaxies assembled earlier and faster than the discs of unbarred galaxies. We also find that barred galaxies are typical in haloes with larger concentrations and smaller spin parameters than unbarred galaxies. Furthermore, the inner regions of barred galaxies are more baryon-dominated than those of unbarred galaxies but have comparable global stellar mass fractions. Our findings suggest that the bar population could be used as a potential tracer of the buildup of disc galaxies and their host haloes. With this paper, we release a catalogue of barred galaxies in TNG50 at six redshifts between z = 4 and 0.
Illustrating galaxy–halo connection in the DESI era with illustrisTNG
Authors: Yuan Sihan , Hadzhiyska Boryana , Bose Sownak , Eisenstein Daniel J
Published: March 2022

We employ the hydrodynamical simulation illustrisTNG to inform the galaxy–halo connection of the Luminous Red Galaxy (LRG) and Emission Line Galaxy (ELG) samples of the Dark Energy Spectroscopic Instrument (DESI) survey at redshift z ∼ 0.8. Specifically, we model the galaxy colours of illustrisTNG and apply sliding DESI colour–magnitude cuts, matching the DESI target densities. We study the halo occupation distribution (HOD) model of the selected samples by matching them to their corresponding dark matter haloes in the illustrisTNG dark matter run. We find the HOD of both the LRG and ELG samples to be consistent with their respective baseline models, but also we find important deviations from common assumptions about the satellite distribution, velocity bias, and galaxy secondary biases. We identify strong evidence for concentration-based and environment-based occupational variance in both samples, an effect known as ‘galaxy assembly bias’. The central and satellite galaxies have distinct dependencies on secondary halo properties, showing that centrals and satellites have distinct evolutionary trajectories and should be modelled separately. These results serve to inform the necessary complexities in modelling galaxy–halo connection for DESI analyses and also prepare for building high-fidelity mock galaxies. Finally, we present a shuffling-based clustering analysis that reveals a 10–15 ${{\ \rm per\ cent}}$ excess in the LRG clustering of modest statistical significance due to secondary galaxy biases. We also find a similar excess signature for the ELGs, but with much lower statistical significance. When a larger hydrodynamical simulation volume becomes available, we expect our analysis pipeline to pinpoint the exact sources of such excess clustering signatures.
Scatter in the satellite galaxy SHMR: fitting functions, scaling relations, and physical processes from the IllustrisTNG simulation
Authors: Niemiec Anna , Giocoli Carlo , Cohen Ethan , Jauzac Mathilde , Jullo Eric , Limousin Marceau
Published: March 2022

The connection between galaxies and their dark matter haloes is often described with the stellar-to-halo mass relation (SHMR). Satellite galaxies in clusters follow an SHMR distinct from central galaxies because of the environmental processes that they are subject to, and the variety of accretion histories leads to an important scatter in this relation. In this work, we use the suite of magnetohydrodynamical simulations IllustrisTNG to study the scatter in the satellite galaxy SHMR, and extract the parameters that can best allow to understand it. Active galaxies, that represent a very small fraction of cluster galaxies, follow a very different relation than their passive counterparts, mainly because they were accreted much more recently. For this latter population, we find that the distance to the cluster centre is a good predictor of variations in the SHMR, but some information on the galaxy orbital history, such as the distance of closest approach to the host centre, is an even better one, although it is in practice more difficult to measure. In addition, we found that galaxy compactness is also correlated with the SHMR, while the host cluster properties (mass and concentration, formation redshift, mass and size of BCG) do not play a significant role. We provide accurate fitting functions and scaling relations to the scientific community, useful to predict the subhalo mass given a set of observable parameters. Finally, we connect the scatter in the SHMR to the physical processes affecting galaxies in clusters, and how they impact the different satellite subpopulations.