bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring diseases/traits and blood proteins causally related to expression of ACE2, the putative receptor of SARS-CoV-2: A Mendelian Randomization analysis highlights tentative relevance of diabetes-related traits
Authors: RAO Shitao , LAU Alexandria , SO Hon-Cheong
Published: May 2020

OBJECTIVES: COVID-19 has become a major public health
problem. There is good evidence that ACE2 is a receptor for SARS-CoV-2, and
high expression of ACE2 may increase susceptibility to infection. We aimed to
explore risk factors affecting susceptibility to infection and prioritize drug
repositioning candidates, based on Mendelian randomization(MR) studies on ACE2
lung expression.

METHODS: We conducted a phenome-wide MR study to prioritize
diseases/traits and blood proteins causally linked to ACE2 lung expression in
GTEx. We also explored drug candidates whose targets overlapped with the
top-ranked proteins in MR, as these drugs may alter ACE2 expression and may be
clinically relevant.

RESULTS: The most consistent finding was tentative evidence
of an association between diabetes-related traits and increased ACE2
expression. Based on one of the largest GWAS on type 2 diabetes(T2DM) to
date(N=898,130), T2DM was causally linked to raised ACE2
expression(p=2.91E-03;MR-IVW). Significant associations(at nominal
level;p<0.05) with ACE2 expression was observed across multiple DM datasets
and analytic methods, for type 1 and 2 diabetes and related traits including
early start of insulin. Other diseases/traits having nominal significant
associations with increased expression included inflammatory bowel disease,
(ER+)breast and lung cancers, asthma, smoking and elevated ALT. We also
identified drugs that may target the top-ranked proteins in MR, such as
fostamatinib and zinc.

CONCLUSIONS: Our analysis suggested that diabetes and
related traits may increase ACE2 expression, which may influence susceptibility
to infection(or more severe infection). However, none of these findings
withstood rigorous multiple testing corrections(at FDR<0.05). Proteome-wide
MR analyses might help uncover mechanisms underlying ACE2 expression and guide
drug repositioning. Further studies are required to verify our findings.
Parametrization methodology for laser remelting applied over laser metal deposition single tracks
Authors: Pôrto Rodolfo Marques , de Souza Pinto Pereira Adriano , Pereira Milton
Published: May 2020

Laser metal deposition (LMD) is increasingly becoming an interesting tool in recent years, especially as one capable of repairing complex metal parts or depositing special materials over the surfaces of high-reliability components. Regardless of the application, and when and where LMD is used, material microstructure optimization is aimed in order to achieve better component performance. The conjunction of LMD with laser remelting was already researched in order to achieve superior properties; however, the mathematical understanding of how the remelting process parameters influence the outcome regarding the amount of material affected is still blurry. Having this in mind, this work combined experimentation and measuring techniques in a design of experiments to obtain data from remelted LMD tracks, thus attempting to evaluate the relationship between remelting speed, laser power, and remolten volume. The procedure used in such design of experiments, and the mathematical correlations developed, are brought here to ease process parametrization of the laser deposition and remelting of Inconel 625. Confirming the findings in previous works, it was observed that it is possible to obtain a relation between laser power and laser remelting speed to a given amount of the remelted material, albeit improvement was possible due to changes in considerations and a broader design of experiments. By the end, with known clad dimensions and a laser remelting speed chosen, specific laser powers could be calculated for a desired amount of material to be remelt with more precision. The main source of deviation is judged to be the differences between the observed and the assumed perpendicular remelted profiles. Compensation for this deviation remains for further works. Nonetheless, an exponential mathematical correlation between the process parameters and the quantity of remelted material on a clad was found. Such correlation can be used to ease the remelting process parametrization of almost any given clad with small error, allowing then, through track laser remelting, the overall improvement of LMD deposition.
De to veiene til dødshjelp
Authors: Kleiven Daniel Joachim H.
Published: May 2020

This chapter’s claim is that arguments for legalising assisted dying essentially follow one of two paths. We can either justify it in the person’s self-determination (the “autonomy path”), or in the person having rational, good reasons for his death wish (the “rationality path”). Both these lines of argument have radical consequences when their logical implications are fully pursued, and an attempt to balance these principles will be under constant pressure. This presents a challenge to those who think it is fairly straightforward to design our preferred assisted dying law, and should make us think through carefully what any legalisation will entail and what principles underlie it. If we take the principle of self-determination seriously, it leads to a very liberal assisted dying law that few Nordic advocates of legalisation would want. On the other hand, choosing the path of rationality requires that we, as a society, define criteria for when life is “not worth living”, based on characteristics that large groups of fellow human beings possess, including those who do not share a desire to die.
En leges nei til dødshjelp
Authors: Horn Morten A.
Published: May 2020

While there is broad support for assisted dying in the general public, many doctors say no – no to performing it, no to legalising it. What explains this resistance? This chapter deals with the counterarguments against assisted dying, from a professional ethics standpoint and a doctor’s outlook. I will present the eight main reasons why I as a doctor say no to euthanasia. The same reasons can be found in declarations on assisted dying from medical and specialist associations worldwide. A recurring feature is that they do not necessarily presuppose a categorical rejection of assisted dying as an isolated phenomenon, or a morally grounded rejection of the euthanasia act. The most important concern is how the doctor will be able to cope with the extremely difficult question of whether another person should be helped to die. At the same time the doctor must preserve the care of vulnerable individuals, as well as the doctor’s own role and values.
Trauma, Cura, Comunidade: As Faces de Cristo em Amada, de Toni Morrison
Authors: Santos José De Paiva dos
Published: May 2020

Este artigo tem como objetivo fazer uma análise de Amada, de Toni Morrison, com foco especial nos elementos intertextuais bíblicos acerca de Jesus e seu ministério. Usando como pano de fundo as reflexões da teologia da libertação negra, argumenta que em Amada Morrison investe seus personagens de características cristológicas com o propósito principal de interrogar formas eurocêntricas de se fazer teologia, ou seja, um teologizar insensível aos anseios, necessidades e sofrimentos das comunidades negras afetadas pelo racismo e opressão fruto da supremacia branca. No romance, Morrison privilegia uma reflexão que abraça princípios, símbolos e elementos da fé cristã, mas que os coloca no contexto da espiritualidade e cultura das comunidades afrodescendentes. Assim, surge um teologizar mais contextual, que valoriza formas e expressões locais de se pensar a relação com a Alteridade.
Prefácio
Authors: Manzatto Antonio , Zeferino Jefferson
Published: May 2020

Teoliterária n. 20
"O Cristo Morto”, de Dostoiévski
Authors: Golin Luana Martins
Published: May 2020

Sabe-se que a literatura de Dostoiévski dialoga intensamente com muitas narrativas bíblicas do Novo Testamento. Jesus e Quixote foram as inspirações para a composição da personagem Míchkin, o príncipe idiota que leva o nome do romance. O tema da morte tangencia toda a narrativa de “O Idiota”. O quadro “Cristo Morto” emerge em algumas cenas, transbordando em novos sentidos. O contato das personagens Míchkin e Hippolit e o próprio contato que Dostoiévski teve diante do quadro, da imagem do cadáver de Cristo, possibilitará uma releitura demasiadamente humana da personagem Cristo.
Ensino bilíngue e inclusão de estudantes surdos no ensino regular: análise de uma carta aberta dos primeiros doutores surdos brasileiros em Educação e Linguística
Authors: Storto Letícia Jovelina , Rocha Luiz Renato Martins da , Cruz Gilmar De Carvalho
Published: May 2020

Neste texto, objetivamos realizar uma leitura da carta aberta dos primeiros doutores surdos que atuam em Educação e em Linguística, em solo brasileiro, enviada em junho de 2012 ao então ministro da educação. Na carta, seus autores discutem a respeito do ensino dirigido aos estudantes surdos no país, defendendo um modelo de ensino considerado por eles como o mais coerente a tal contexto. Para tanto, apresentamos uma breve reflexão a respeito das filosofias existentes no processo de ensino/aprendizagem desses sujeitos. Adotamos a metodologia de pesquisa bibliográfica e documental, pois realizamos um levantamento teórico das questões que envolvem o ensino e a inclusão de alunos surdos brasileiros e examinamos uma carta aberta como fonte e objeto de pesquisa. Na carta, os autores defendem o bilinguismo na educação de surdos, argumentando em defesa de tal perspectiva como aquela que melhor condiz com a inclusão escolar desses sujeitos.
¬Palavreando: uma proposta de aplicativo educacional móvel de aprendizagem de palavras em Português-Libras para surdos
Authors: Dorta Jéssica Vasconcelos
Published: May 2020

Recorte de minha dissertação de mestrado, o presente trabalho, situado no campo da Linguística Aplicada, apoia-se nas teorias do círculo bakhtiniano (BAKHTIN/ VOLÓCHINOV, 2017) para apresentar as principais características do  Palavreando: uma proposta de aplicativo educacional móvel para surdos,  cujo objetivo central  é auxiliar a aprendizagem de palavras em Português-Libras. Para o desenvolvimento da proposta, parti da ideia de que a aprendizagem de palavras realiza-se como um processo discursivo, plurilíngue e multimodal de construção de sentidos. Atualmente, o app é objeto de estudo de uma pesquisa doutoral em andamento e encontra-se em fase de pilotagem. Espera-se que o Palavreando venha a constituir-se como um recurso que possibilite aos surdos resistirem aos sentidos estabilizados, resignificá-los e construí-los segundo seus repertórios e experiências de vida. Para tanto, o aplicativo deve ser compreendido como um objeto que ganha vida no uso pela comunidade e que, portanto, está em constante processo de (re)construção.
Resenha: Paul Ricoeur de A a Z
Authors: Anéas André
Published: May 2020

Resenha: Paul Ricoeur de A a Z
Medicina Basada en la Evidencia. Lectura Crítica de “Guías de Práctica Clínica”
Authors: Simancas-Racines Daniel , Zambrano-Achig Paula , Montesinos-Guevara Camila , Guerra-Cevallos Verónica , Zambrano Victoria , Hidalgo Ottolenghi Ricardo
Published: May 2020

Las guías de práctica clínica (GPC) son documentos que incluyen recomendaciones basadas en la evidencia científica para la toma de decisiones clínicas; al mismo tiempo, pueden desempeñar un papel importante en la elaboración de políticas de salud. Por lo tanto, es crucial que se evalúe críticamente su calidad y aplicabilidad en diversos contextos, para lo cual se ha desarrollado la herramienta AGREE II. Este artículo tiene como objetivo dar a conocer el desarrollo, la aplicación y la evaluación de la calidad de las guías de práctica clínica, de manera que se pueda realizar una lectura crítica de las mismas.
Evaluation of sound pressure levels in a pediatric intensive care unit
Authors: Mendes Caroline De Araújo , Da Silva Carlos Roberto Lyra , De Souza Luciane Velasque , Bridi Adriana Carla , Cabral Joice Alves , Dutra Luana Borges , Barreiros Raphael Neves , Garcia Andrea Dos Santos , Salú Margarida Dos Santos , Barroso Natália
Published: May 2020

This study objectives were to measure the sound pressure levels found in the pediatric intensive care unit in a federal institution of Rio de Janeiro; to verify differences in noise levels during the morning and afternoon; to confront the sound pressure levels found against acceptable levels according to national and international noise organizations; to count the quantity of alarms triggered by each type of medical care equipment selected (multiparameter monitor, mechanical ventilator and infusion pump); to verify the relevance in the scientific world about pediatric intensive care unit noise through bibliometrics and to address the trinomial care technology - noise - implications on care. It’s an observational, exploratory, quantitative study, organized in three steps: Parameter collection and decibel meter calibration - data were based on the study by Salú, et al (2015) ; Data collection: 40 hours of discontinued observation (8am to 16pm) on different days for a period two months using two decibel meters; Data processing: An Excel spreadsheet was created for the database and data analysis was performed with the help of Microsoft Office Excel 2010 and Program R, organized into graphs and tables. 61% of the alarms corresponded to the mechanical ventilator; Bed E had the lowest standard deviation (SD = 2.945) and the highest median (69.5dBA). Even by removing the E bed from the analysis, there is a significant difference (p <0.001) between sound pressure levels. The median of the afternoon (28.2dBA); and morning (26.1dBA). Mechanical fan and monitor generated higher sounds; the pediatric intensive care unit has considerably exceeded that recommended by national and international noise organizations; afternoon generated higher sounds than morning. Keywords: Noise Meters; Noise; Intensive care; Pediatrics
Ontology Learning pada Teks Tidak Terstruktur
Authors: Yunmar Rajif Agung
Published: May 2020

Informasi yang tersebar pada berbagai sumber di internet banyak ditujukan hanya untuk manusia saja. Sementara itu, muncul kebutuhan agar informasi tersebut tidak hanya bisa dibaca dan dipahami oleh manusia saja, tetapi juga oleh mesin. Informasi dalam format yang dapat dipahami oleh mesin dapat digunakan untuk berbagai keperluan, misalnya: menjadi basis pengetahuan untuk penalaran, sharing knowledge antar mesin, semantic search, visualisasi informasi, dsb. Ontology learning adalah metode yang dapat mengekstrak informasi dari teks tidak terstruktur pada suatu dokumen atau halaman web untuk kemudian diubah menjadi basis pengetahuan dalam format yang dapat dipahami oleh mesin, yaitu dalam bentuk ontologi. Metode tersebut terdiri dari beberapa tahapan, yaitu: preprocessing, ekstraksi konsep, ekstraksi relasi, dan evaluasi. Preprocessing menyiapkan korpus uji sehingga siap untuk masuk kedalam metode ekstraksi konsep, yang menggunakan algoritma entropy concept extraction, pada bagian ekstraksi relasi digunakan algoritma subcat relation extraction, sedangkan pada bagian evaluasi ontologi menggunakan metode expert evaluation. Hasil akhir menunjukkan akurasi pada nilai 89.84% untuk ekstraksi konsep, 93.02% untuk ekstraksi relasi, dengan kepercayaan terhadap ekstraksi relasi pada prosentase 71.15%.

Kata kunci: ontology learning, entropy concept extraction, subcat relation extraction.
From Barracks to Garden Cities
Authors: Bergenheim Sophy
Published: May 2020

This article examines how Väestöliitto, the Finnish Population and Family Welfare League, developed into a housing policy expert during the 1940s and 1950s. Through frame analysis, I outline how Väestöliitto constructed urbanisation and ‘barrack cities’, i.e. an urban, tenement-based environment, as a social problem and how, respectively, it framed ‘garden cities’ as a solution. In the 1940s, Väestöliitto promoted a national body for centralised housing policy and national planning. When the ARAVA laws (1949) turned out to be a mere financing system, Väestöliitto harnessed its expertise into more concrete action. In 1951, together with five other NGOs, Väestöliitto founded the Housing Foundation and embarked on a project for constructing a model city. This garden city became the residential suburb Tapiola. This marked a paradigm shift in Finnish town planning and housing policy, which had until then lacked a holistic and systematic approach. Along the 1940s–1950s, Väestöliitto thus constructed and developed its expertise from an influential interest organisation to a concrete housing policy actor.
The Story of an Unusual Book
Authors: German
Published: May 2020

The article analyses the history of a Festschrift dedicated in 1987 to Ymär Daher (1910–1999), awell-known activist in the Tatar community of Finland. Two aspects of the volume are discussedin detail: why there was an astonishingly high number of Tatar authors from the Soviet Union andwhy one of the Tatar-language articles in the volume was published not in Cyrillic, the officialscript for the language in the Soviet Union, but in Arabic script. The article tries to find answers tothese questions by following the life and the networking activities of the jubilee of the Festschriftand the life of Enže Säġidova (1921–1997), the author of the Arabic-script article in the volume.
Analisis Perbandingan Website Digilib dengan Metode Penghitungan Usability Menggunakan Kuesioner SUS
Authors: Aji Hafidz Pudyastawa , DPA, , S.T, M.Kom Nur Rochmah
Published: May 2020

Abstract: This study aims to analyze the comparison of Digilib websites at 3 universities. Digital Library is a media for storing book collections in digital form, as a means to facilitate visitors in accessing book collections. In improving services, universities X, Y, and Z have provided Digilib. Observation results indicate the number of Digilib visitors is still relatively small. Therefore quality evaluation on the Digilib website needs to be done. Quality evaluation on the Usability aspect is carried out using the existing assessment standards on the SUS questionnaire. Analysis and data processing of questionnaire results using SUS calculation. The results of the calculation of the average SUS score of 51 respondents from each university X, Y, and Z showed that, Digilib X had the highest SUS score of 58.2. The results of the score analysis indicate that the three websites have not met the usability aspect in terms of learnability. The SUS aspect analysis is used as a development reference to maximize the quality of Digilib services.Keywords: Quality Evaluation, Digital Library, Usability. Abstrak: Penelitian ini bertujuan menganalisis perbandingan website Digilib pada 3 universitas. Digital Library merupakan suatu media penyimpanan koleksi buku dalam bentuk digital, sebagai sarana untuk memudahkan pengunjung dalam mengakses koleksi buku. Dalam meningkatkan pelayanan, universitas X, Y, dan Z telah menyediakan Digilib. Hasil observasi menunjukkan jumlah pengunjung Digilib masih tergolong kecil. Oleh sebab itu evaluasi kualitas pada website Digilib perlu dilakukan. Evaluasi kualitas pada aspek Usability dilakukan menggunakan standar penilaian yang ada pada kuesioner SUS. Analisis dan pengolahan data hasil kuesioner menggunakan penghitungan SUS. Hasil perhitungan rata-rata skor SUS dari 51 responden masing-masing universitas X, Y, dan Z menunjukan bahwa, Digilib X memiliki skor SUS tertinggi yaitu 58,2. Hasil analisis skor menunjukkan bahwa ketiga website belum memenuhi aspek usability dari segi learnability. Analisis aspek SUS digunakan sebagai acuan pengembangan untuk memkasimalkan kualitas pelayanan Digilib.Kata Kunci: Evaluasi Kualitas, Digital Library, Usability.
ANALISIS KINERJA PEMERINTAH DAERAH (PEGAWAI PUSKESMAS) DALAM PELAYANAN KESEHATAN MASYARAKAT DI PUSKESMAS MAKBON KECAMATAN MAKBON KABUPATEN SORONG
Authors: Pakpahan Ratna Rosmauli
Published: May 2020

Berdasarkan hasil pengamatan peneliti pada Puskesmas Makbon Distrik Makbon Kabupaten Sorong diperoleh bahwa kinerja pemerintah daerah (pegawai puskesmas) dalam meningkatkan pelayanan kesehatan kepada masyarakat cukup baik. Namun masih ada kendala-kendala yang dialami oleh pegawai puskesmas makbon dalam hal perumahan pegawai, dan sarana transportasi darat dan laut yang harus di perhatikan lagi oleh pemerintah daerah untuk menunjang pelayanan puskesmas keliling ke kampung-kampung (pusling) masih kurang. Metode yang digunakan adalah metode penelitian kualitatif. Dari hasil penelitian peneliti dapat menyimpulkan bahwa perhatian dari pemerintah daerah kepada masyarakat dalam pelayanan kesehatan melalui pegawai puskesmas masih kurang. Oleh karena itu saran yang dapat peneliti kemukakan berupa saran praktis dengan lebih memperhatikan hal-hal yang harus dilakukan pemerintah daerah terhadap pelayanan kesehatan kepada masyarakat di Puskesmas Makbon Kabupaten Sorong.
Трансапикальная имплантация протеза «МедЛАБ-КТ» в опорное кольцо митрального клапана
Authors: Bazylev V.V. , Voevodin A.B. , Allenov A.A. , Tungusov D.S.
Published: May 2020

Рецидив значимой митральной регургитации после пластики клапана традиционно требует реоперации: повторной реконструкции или протезирования. Для пациентов, относящихся к категории высокого хирургического риска, транскатетерная имплантация протеза в опорное кольцо, вшитое при первичной операции, является альтернативным вариантом радикального лечения. В данном сообщении представлены клинические предпосылки, технические особенности и непосредственные результаты успешной транскатетерной имплантации протеза клапана сердца МедЛАБ-КТ в митральную позицию после пластики опорным кольцом Карпантье у пациента 54 лет с высоким риском повторного открытого вмешательства.
Профилактика осложнений после операции протезирования аортального клапана, выполненной в детском и подростковом возрасте
Authors: Medvedeva O.I. , Ermolenko M.L. , Nevedrova M.N. , Samsonov V.B. , Danilov T.IU. , Kovalev D.V. , Doncova V.I. , Plahova V.V.
Published: May 2020

Введение.При имплантации механического клапана в детском и подростковом возрасте существуют постоянная потребность в приеме антикоагулянтов, возможность развития тромбоэмболий и геморрагических осложнений, необходимость в проведении повторной операции в связи с дисфункцией протеза или возникновением несоответствия размера протеза площади поверхности тела ребенка при его росте. Цель. Изучить наиболее часто встречающиеся осложнения в отдаленные сроки после операции протезирования аортального клапана (АК), выполненной в детском и подростковом возрасте, и определить пути их профилактики. Материал и методы. Обследовано 120 пациентов после протезирования АК, из них 90 (75) мужского пола, 30 (25) женского. Возраст на момент операции варьировал от 3 до 18 лет (в среднем 12,73,3 года). Частота развития кровотечений составила 5, тромбоэмболий 7,5. Повторные хирургические вмешательства проведены 20 (16,7) пациентам. Заключение. Для предотвращения и эффективного лечения осложнений необходимы постоянный контроль антикоагулянтной терапии и регулярное наблюдение кардиолога в кардиохирургическом центре с проведением инструментальных обследований.
Результаты открытой и баллонной вальвулопластики аортального клапана при коррекции врожденного стеноза аорты у детей до 1 года
Authors: CHernogrivov A.E. , Bofanov D.A. , CHernogrivov I.E. , SHmatkov M.G. , Nazarova I.S. , Bazylev V.V.
Published: May 2020

Цель. Проанализировать результаты различных видов вмешательств на аортальном клапане (АК) у пациентов до 1 года с врожденным стенозом АК. Материал и методы.В период с 2008 по 2018 гг. в ФЦССХ Минздрава России (г. Пенза) было выполнено 84 оперативных вмешательства по поводу врожденного аортального стеноза у пациентов до 1 года. В зависимости от типа вмешательства были выделены две группы. В 1-ю вошли пациенты, которым выполнялась открытая хирургическая коррекция порока (n46), во вторую пациенты после выполнения транслюминальной баллонной вальвулопластики (n38). Медиана возраста на момент операции составила 53 дня (1327 дней). Результаты. Ранняя общая послеоперационная летальность составила 3,5 (n3). Отдаленная послеоперационная летальность отсутствовала. Повторные открытые операции были выполнены у 8 (9,5) пациентов. Актуарная свобода от реопераций в сроки наблюдения до 10 лет для пациентов 1-й группы составила 86,62,2, для пациентов 2-й 57,82,3 (p0,04). Было выявлено статистически достоверное влияние следующих факторов риска на вероятность рестеноза АК в отдаленном периоде: выполнение баллонной вальвулопластики (отношение шансов (ОШ) 1,87 доверительный интервал (ДИ) 1,113,21 p0,04), резидуальный градиент систолического давления (ГСД) на АК на момент выписки (ОШ 1,1 ДИ 1,021,41 p0,01). Выводы. Результаты проведенного исследования позволяют считать выполнение как вальвулопластики в условиях искусственного кровообращения, так и баллонной вальвулопластики эффективными методами коррекции аортального стеноза у детей до 1 года. Транслюминальная баллонная вальвулопластика (ТЛБВП) у детей первого года жизни может применяться как самостоятельное вмешательство либо использоваться как I этап коррекции порока, но сопровождается более частыми повторными вмешательствами на АК в отдаленном периоде. Высокие цифры ГСД в послеоперационном периоде увеличивают риск выполнения реоперации.
Cлучай успешной операции артериального переключения при транспозиции магистральных артерий у недоношенного с низкой массой тела
Authors: Gulasarian R.S. , Tumanian M.R. , Kim A.I. , Zubkova S.A.
Published: May 2020

Операция артериального переключения является операцией выбора при лечении транспозиции магистральных артерий (ТМА). Успех кардиохирургической коррекции врожденных пороков сердца в периоде новорожденности обусловлен как анатомическими особенностями порока, так и наличием дополнительных нехирургических факторов риска. Одним из них, наиболее грозным, является недоношенность. Недоношенность и малый вес пациента утяжеляют исход хирургического лечения ТМА. Описанный в данной статье клинический случай демонстрирует успешное артериальное переключение при ТМА у недоношенного новорожденного с низкой массой тела.
ТЕХНОЛОГИЯ ПРИМЕНЕНИЯ УСТАНОВОК ЦЕНТРОБЕЖНОГО МОДЕЛИРОВАНИЯ ДЛЯ РЕШЕНИЯ ГЕОТЕХНИЧЕСКИХ ЗАДАЧ (ЧАСТЬ 02 УСТАНОВКА ЦЕНТРОБЕЖНОГО МОДЕЛИРОВАНИЯ РУТ(МИИТ). ЦЕНТРИФУГА И ВСПОМОГАТЕЛЬНЫЕ УСТРОЙСТВА ПО ОПЫТУ ЭКСПЛУАТАЦИИ)
Authors: ЗАЙЦЕВ АНДРЕЙ
Published: May 2020

Данный препринт (второй по счету) продолжает тему технологии применения центробежного моделирования.
Комплекс физического моделирования грунтовых сооружений РУТ(МИИТ) включает собственно установку центробежного моделирования (разработки и установки в 1959-1961 г.г.) и комплекс вспомогательных устройств, созданный в Путеиспытательной лаборатории, секторе земляного полотна (1961–1997 г.г.), позднее учебно-исследовательском центре «Моделирование инженерных сооружений» (2000-2016г.г. и по настоящее время) кафедры “Путь путевое хозяйство” ИПСС РУТ (МИИТ).
Применение универсальной математической модели эпидемического процесса «SRID» для прогноза развития эпидемии COVID-19 в городе Москва
Authors: Букин Юрий , Джиоев Юрий , Бондарюк Артем , Ткачев Сергей , Злобин Владимир
Published: May 2020

В работе представлена универсальная математическая модель эпидемического процесса «SRID», позволяющая с помощью бутстрэп анализа оценить доверительные интервалы для важнейших параметров эпидемического процесса с учетом погрешностей в исходных статистических данных. На основе модели получены варианты прогнозов возможного развития эпидемии COVID-19 в г. Москва по исходным данным за период с 25.03.2020 г. по 21.04.2020 г. при «естественном» течении эпидемического процесса и при принятии эффективных противоэпидемических мер. Значение параметра R_0 (базовое репродуктивное число) в варианте без учета проведения профилактических мер составило от 3,22 до 6,89, что существенно выше этого показателя для других сезонных эпидемий – гриппа и ОРВИ. При таком R_0 пик эпидемии придется на период с 10.05.2020 г. до 05.06.2020 г., а смертность от эпидемии может составить от 24620 до 57032 человек. Для сокращения продолжительности и уменьшения последствий эпидемии необходим комплекс мер, направленных на снижение значения R_0, к которым следует отнести эффективные изоляционные, карантинные и дезинфекционные мероприятия. В случае их успешной реализации пик эпидемии придется на срок от 10.05.2020 г. до 05.06.2020 г., а смертность по итогам эпидемии может составить от 407 до 2573 человек. Оценка факторов возможного развития эпидемии имеет большое значение для принятия управляющих решений медицинского и экономического характера в масштабах всей РФ. Скрипт и для языка программирования R, реализующие модель «SRID» и первичные данные по г. Москва доступны по ссылке: https://github.com/barnsys/r_srid_model.
Urbanidade, tecido urbano e cursos d'água: um estudo em Goiânia e Florianópolis | Urbanity, urban fabric and water streams: a study in Goiânia and Florianópolis (Brazil)
Authors: Soares de Sousa Carinna , Reis Almir Francisco
Published: May 2020

A realidade brasileira tem mostrado umafastamento progressivo entre o homem e os rios urbanos: cidades com processos de crescimento urbano e estruturas naturais diferenciadas têm repetido uma relação de negligência e descaso nas margens desses corpos d’água. Partindo dessa premissa, este trabalho identifica relações espaciais estabelecidasentre traçado urbano e cursos d’água, tipificando interfaces e ambiências urbanas aípresentes. Problematizando o papel das configurações espaciais no desenvolvimento de condições adequadas para apropriação social e preservação ambiental nas margens dos rios urbanos, realizaram-se estudos morfológicos, complementados por leituras de campo, em duas bacias hidrográficas: a bacia hidrográfica do córrego Cascavel, na cidade de Goiânia, e a bacia hidrográfica do rio Itacorubi, situada em Florianópolis. A partir desses estudosde caso, que apresentam bacias hidrográficas em situações geomorfológicas e urbanísticas bastante específicas, o trabalho conclui que, na preservação dos rios urbanos, urbanidade e efetiva apropriação podem ser valores auxiliares para torná-los mais visíveis, reconhecíveis e acessíveis no cotidiano de sua população.
Distribuição de atividades econômicas e centralidades em redes espaciais urbanas: estudo de caso: Lorena (Brasil) | Distribution of economic activities and centralities in urban spatial networks: study case:Lorena (Brazil)
Authors: Lima Leonardo , Ribeiro Bárbara Maria Giaccom
Published: May 2020

Ultimamente, a aplicação de redes espaciais urbanas vem ganhando destaque em trabalhos que envolvem Sistemas de Informação Geográfica. Assim, modelos de centralidade têm sido aplicados a fim de diferenciar espaços e descrever aspectos vinculados à estrutura espacial urbana. Neste trabalho, é explorada a relação entre o fenômeno da distribuição de atividades econômicas e as propriedades do espaço urbano, utilizando-se a teoria de redes como base metodológica. Considerando-se três propriedades espaciais — Acessibilidade, Intermediação e Excentricidade —, foram aplicados modelos de centralidade capazes de diferenciar porções discretas de espaço urbano sobre a rede espacial formada por trechos de ruas da cidade de Lorena (São Paulo). Nasequência, os resultados da aplicação desses modelos foram comparados, estatisticamente, com suas respectivas quantidades de atividades econômicas.O coeficiente de correlação Pearson (r) foi utilizado para verificar qual desses modelos se associaria ao fenômeno da distribuição de atividades econômicasurbanas de forma mais adequada. Os resultados sugerem uma correlação moderada entre os valores de centralidade por excentricidade e centralidadepor proximidade, processadas de forma geométrica, com a distribuição espacial de atividades econômicas na cidade de Lorena (São Paulo).
Passeio Sonoro Comentado: metodologia de identificação da paisagem sonora representada por pessoas surdas | Commented soundwalk: methodology for identifying the soundscape representedby deaf people
Authors: Simili Juliana , Queiroz Rego Andrea
Published: May 2020

O tema deste artigo é a paisagem sonora representada pelas pessoas surdas através de uma experiência com o som para além da audição. Adota-se uma interpretação socioantropológica da surdez, incorporando proposições identitárias e culturais próprias a esse grupo de pessoas. Nesse aspecto, o artigo objetiva apresentar a metodologia dos “Passeios Sonoros Comentados”, que visa à identificação e à organização da apreensão das sonoridades urbanaspelos surdos, a seu próprio modo. As discussões e considerações finais apontam para as diferenças de interpretações sonoras entre surdos e ouvintes e sua influência na relação do surdo com o espaço urbano.
DAFTAR ISI, EDITORIAL DAN LEMBAR ABSTRAK Volume 12, Nomor 2, Desember 2017
Authors: Kebudayaan Jurnal
Published: May 2020

DAFTAR ISI, EDITORIAL DAN LEMBAR ABSTRAK Volume 12, Nomor 2, Desember 2017
Evaluating the security of the fiscal and budgetary system of the Kemerovo Oblast
Authors: Sheveleva O.B. , Slesarenko E.V.
Published: May 2020

Subject. The article deals with the security of the fiscal and budgetary system in resource-based regions during highly volatile prices in the global energy market external economic, political, technological and epidemiological shocks.
Objectives. The study is to detect hazards in the fiscal and budgetary system of resource-based regions. Such hazards really put the regional competitiveness and economic security at peril.
Methods. The article evaluates the security of the fiscal system in the Kemerovo Oblast through the integral indicator and the threshold (critical) value.
Results. We found key threats to the fiscal and budgetary system of the Kemerovo Oblast, which undermine the regional competitiveness and economic security.
Conclusions and Relevance. Authorities shall comprehensively attempt to create the environment for developing manufacturing sectors in the region, especially science-intensive and high-tech production enterprises by alleviating infrastructure and administrative constraints for business, raising the finance of science and innovation from the State and mobilize investors' resources, lure them to finance prioritized lines of the regional economic development. The findings and conclusions can be used to outline principles of the region's economic policy, socioeconomic development strategies of the region economy.
Environmental innovation in the RF Arctic Zone regions as a tool to realize the demographic potential
Authors: Tortsev A.M. , Studenov I.I.
Published: May 2020

Subject. This article discusses the issues of balanced development of regions, the Man-Environment system, and the introduction of environmental innovation in technological processes.
Objectives. The article aims to analyze the adoption of environmental innovation in terms of realizing the demographic potential of the Arctic regions of Russia.
Methods. For the study, we used a content analysis, statistical data qualitative and cause-and-effect analyses, grouping, and systematization.
Results. Most regions of the Arctic show significant levels of environmental impact, including atmospheric air, surface water and land. There is a high disease incidence of the population in the Arctic areas. The proportion of companies implementing environmental innovation in technological processes is negligible.
Conclusions. The article concludes that it is appropriate to accelerate the pace of environmental innovation in economic activity. This will help reduce pollution and have a positive impact on public health.
PENGARUH KETERAMPILAN WIRAUSAHA DAN SPIRITUALITAS TERHADAP KINERJA ORGANISASI UKM SEKTOR KULINER DI KOTA SURABAYA
Authors: Wibowo Tony Susilo
Published: May 2020

Small and Medium Enterprises (SMEs) is one important element in boosting the Indonesian economy, especially in the culinary sector. The Indonesian Agency for Creative Economyreleased data in 2015 the contribution of the creative economy to the Gross Domestic Product (GDP) of Rp 852 trillion and 8.2 million units are creative industries, and 68% are in the culinary sector and contribute to the GDP of 41.69%.On the other hand, the existence of SMEs must be supported by entrepreneurial abilities that are reflected in entrepreneurial skills as well as the characteristics of Indonesian society that attach elements of faith through spirituality. This research aims to analyze and describe the influence of entrepreneurial skills and spirituality variables on organizational performance in SMEs. This research approach is quantitative with a questionnaire instrument. Data processing uses multiple linear regression statistical analysis. The study was conducted at the Culinary Tourism Center of Al Akbar Mosque, located on Jalan Menanggal with a period of September - October 2019. After going through descriptive statistical testing, it is known that the entrepreneurial skills variable has a beta value of 0.225 with a significance level of 0.192 and> 0.05 so that the entrepreneurial skills variable does not affect the performance of SME organizations. For testing with spirituality variables, it is known that the beta value of 0.621 with a significance level of 0.011 <0.005 so that spirituality influences the performance of SME organizations. From the tests conducted simultaneously, the variables of entrepreneurial skills and spirituality affect the performance of SME organizations.
Does magnetic resonance imaging increase core body temperature in children? Results of the administration of propofol and ketofol: a randomized clinical study
Authors: Beyoğlu Çiğdem Akyol , Kendigelen Pınar , Beyoğlu İlhan , Altındaş Fatiş , Kuruoğlu Sebuh , Kaya Güner
Published: May 2020

Background and Objectives. Magnetic resonance imaging (MRI) may cause a temperature increase in the imaging area, while intravenous anesthetics may develop a tendency for hypothermia, especially in the pediatric population. The effect of different anesthetics on core body temperature in children during these procedures remains controversial. We examined the effect of propofol and ketofol on core body temperatures in a pediatric population during MRI. Our hypothesis was that the increase in body temperature will be more prominent in pediatric patients receiving ketofol than in those receiving propofol.
Methods. This was a randomized, prospective, double-blind study in pediatric patients aged 6 months to 10 years. The patients were American Society of Anesthesiologist (ASA) physical class I-II who had undergone MRI under anesthesia at the Cerrahpasa School of Medicine, MRI Area, between August 2014 and February 2016. Patients were assigned to one of two groups: Group I (propofol group) and Group II (ketofol group). MRIs were performed with a 1.5 Tesla (T) device. Bilateral tympanic membrane temperature measurements before and after the procedure were performed.
Results. Body temperature decreased in both groups after MRI. Clinically significant hypothermia or hyperthermia was not observed in any of the patients.
Conclusion. Temperature monitoring is not necessary for every patient being imaged. However, temperature changes should be closely monitored in high-risk patients.
Wernicke`s encephalopathy manifesting with diplopia after ileojejunostomy: report of a pediatric case with Hirschsprung disease
Authors: Dilber Beril , Kamaşak Tülay , Eyüboğlu İlker , Kola Mehmet , Uysal Ahmet Taner , Saruhan Haluk , Yalçın Sonay , Sağ Elif , Cansu Ali
Published: May 2020

Background. Wernicke`s encephalopathy (WE) is a coenzyme-induced disease with acute neuropsychiatric symptoms leading to high mortality and morbidity due to thiamine deficiency. WE is mostly caused by alcoholism in adult populations; however, it is often associated with gastrointestinal surgical procedures, recurrent vomiting, chronic diarrhea, cancer and chemotherapy treatment, systemic diseases, drugs, magnesium deficiency, and malnutrition in children. Although these predisposing factors are considered to be uncommon in children, they are actually highly frequent and can be fatal if not treated promptly.
Case. In this report, we present a patient who developed diplopia during total parenteral nutrition following surgical resection and was diagnosed with WE. The findings of the patient's cranial magnetic resonance imaging (MRI) findings were consistent with those of WE and the ocular findings of the patient resolved completely after thiamine treatment.
Conclusion. Although WE is rare in children it can be prevented by early diagnosis and treatment and oculomotor findings such as diplopia can be a warning sign.
Acute necrotizing encephalopathy with organic psychosis: a pediatric case report
Authors: Orgun Leman Tekin , Arhan Ebru , Aydın Kürşad , Torun Yasemin Taş , Güney Esra , Serdaroğlu Ayşe
Published: May 2020

Background. Enteroviruses-associated acute necrotizing encephalopathy (ANE) of childhood is rarely reported in the literature. Clinico-radiological features of ANE are well-recognized and bilateral thalamic nuclei are frequently affected by ANE. Neuropsychiatric symptoms are rarely seen. Thalamic damage can cause psychosis.
Case. Herein, we present a pediatric case of enterovirus-associated ANE presenting with psychosis related to thalamus damage in whom a favorable response to treatment was achieved.
Conclusion. Thalamic damage occurs during the Enteroviruses-associated acute necrotizing encephalopathy and it can be related psychiatric sympthoms. Clinicians should be aware of uncommon presentations of ANE, and patients with thalamic damage should be followed for neuropsychiatric manifestations. Early recognition and appropriate treatment of ANE is important to obtain favorable outcomes.
A rare case of syndromic severe congenital neutropenia: JAGN1 mutation
Authors: Çipe Funda Erol , Aydoğmuş Çiğdem , Baskın Kübra , Keskindemirci Gonca , Garncarz Wojciech , Boztuğ Kaan
Published: May 2020

Background. Neutrophils are essential innate cells to fight bacterial and fungal pathogens. Jagunal homolog 1 (JAGN1) mutations were recently defined as rare genetic defects causing severe congenital neutropenia. JAGN1 participates in the secretory pathway and is required for granulocyte colony-stimulating factor receptormediated signalling. This gene is required for normal ultrastructure and granulation of endoplasmic reticulum of myeloid progenitor cells. Its defect is related to increased predisposition to apoptosis. In the literature, a few cases have been reported with congenital anomalies such as cardiac and renal anomalies.
Case. Here we report a patient in which JAGN1 deficiency was found after several years. Apart from syndromic facial appearance we were unable to detect any other systemic malformations.
Conclusion. The causes of multisystemic features of mutations in JAGN1 gene remain unknown. JAGN1 mutations must be considered in patients with severe congenital neutropenia especially with facial dismorphism even in the absence of systemic manifestations.
Rubella Specific IgG and IgM Antibodies among Infants before Rubella Vaccination in Dar es Salaam, Tanzania: A Cross-Sectional Study
Authors:   Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania, Majigo Mtebe V , Ibrahim Mariam , Manyahi Joel , Mosha Fausta , Mashurano Marcelina , Mhalu Fred S
Published: May 2020

Prevention of Rubella virus infection using rubella vaccine has been widely used in high-income countries contributing to the declining of congenital rubella syndrome. Before introduction of rubella vaccine in Tanzania October 2014, status of rubella specific antibodies in the infant was limited. This study was conducted to assess the rubella specific IgG and IgM antibodies among infants before receiving the vaccine.
Response-Ability Facing Covid-19: A matter of Psyche, Behavior and Civism
Authors:   College Of Psychiatrists Of Ireland And Health Service Executive Hse Summerhill Community Mental Hea, Summerhill, Wexford, Y35 KC58, Ireland, Naviaux Anne Frédérique , Janne Pascal , Gourdin Maximilien
Published: May 2020

The coronavirus is raising many questions and resulting in some steps being taken in some very different (and sometimes even contradictory) directions; this is observed at all levels: international, national, institutional, educational, economic, and includes that of the family, the couple and individually.
Série temporal do suicídio no Brasil: o que mudou após o Setembro Amarelo?
Authors: Oliveira Milena Edite Casé de , Gomes Kedma Anne de Lima , Nóbrega Waleska Fernanda Souto , Gusmão Elaine Custódio Rodrigues , Dos Santos Rayane Dantas , Franklin Ramonyele Gomes
Published: May 2020

Objetivo: Analisar a prevalência das notificações de suicídio no Brasil antes e após o lançamento da Campanha Setembro Amarelo (CSA) pelo Ministério da Saúde. Métodos: Foram utilizados dados secundários contidos no Sistema de Informações sobre Mortalidade (SIM) e no Sistema de Informação de Agravos de Notificação (SINAN) disponibilizados pelo DATASUS. Resultados: O número de casos notificados por intoxicação exógena somou um total de 452.579 pessoas no Brasil, destas, 15% (67.966) correspondiam à categoria “tentativa de suicídio” e 10% (45.901) a causas indeterminadas. Quanto à classificação de transtornos mentais e de comportamento da CID-10, entre 2013 e 2016, os óbitos notificados por “transtorno depressivo recorrente” (F33) vitimaram um total de 236 pessoas, das quais 57% (134) eram mulheres. Conclusão: Mais da metade das mortes violentas no mundo tem como causa o suicídio, tornando-o um problema da saúde pública. No ano de 2015 foi iniciada a Campanha Setembro Amarelo (CSA), que atua na prevenção ao suicídio. As taxas de incidência apresentaram dados ascendentes após a implantação da CSA, permitindo o questionamento a respeito da efetividade do programa. Faz–se necessário acompanhar a campanha por um maior intervalo de tempo, a fim de compreender seus impactos futuros.
Simulation of Excitation by Sunlight in Mixed Quantum-Classical Dynamics
Authors: Barbatti Mario
Published: May 2020

This paper proposes a method to simulate nonadiabatic dynamics initiated by thermal light, including solar radiation, in the frame of mixed quantum-classical (MQC) methods, like surface hopping. The method is based on the Chenu-Brumer approach, which treats the thermal radiation as an ensemble of coherent pulses. It is composed of three steps, 1) sampling initial conditions from a broad blackbody spectrum, 2) dynamics propagation using conventional methods, and 3) ensemble averaging considering the field and realization time of the pulses. The application of MQC dynamics with pulse ensemble (MQC-PE) to a model system of nucleic acid photophysics showed the emergence of a steady excited-state population. In another test case, modeling retinal photophysics, MQC-PE predicted that although the photoisomerization occurs within 200 fs, it may take tens of microseconds of continuous solar irradiation to photoactivate a single retinal. Such emergent long timescales may impact our understanding of biological and technological phenomena occurring under solar radiation.
Direct Observation of Ni–Mo Catalyst Formation via Thermal Reduction of Nickel Molybdate Nanorods
Authors: Patil Rituja , House Stephen , Mantri Aayush , Yang Judith C. , McKone James
Published: May 2020

Ni-Mo composites are known to catalyze several industrial relevant reactions involving hydrogen. Our interest is in Ni-Mo composites for hydrogen evolution reaction in alkaline anion exchange membrane water electrolyzers. We recently found that Ni-Mo composites comprise of core-shell structure where the core is metallic, rich in Ni while the shell is Mo-rich oxide. The transformation of the oxide intermediate into a core-shell architecture is studied in this work using in situ transmission electron microscopy. We reduced nickel molybdate nanorods in environmental transmission electron microscope and observed its transformation into the Ni-Mo catalyst composite. We further correlated these chemical transformations with the observed hydrogen evolution activity.