bluuebunny/crossref_metadata_2025 huggingface dataset:
Intrahepatic sarcomatoid cholangiocarcinoma with portal vein thrombus misdiagnosed as hepatocellular carcinoma: description of a rare case
Authors: Zhan Ting , Xing Shan-Shan , Lu Chun-Hua
Published: March 2023

Less than 1% of malignant tumors of the hepatobiliary system are intrahepatic sarcomatoid cholangiocarcinomas, a rare malignant tumor of the liver. Based only on clinical presentation and imaging, this entity is readily mistaken for hepatocellular carcinoma. In this article, we describe the case of a 36-year-old male patient who had a history of "cirrhosis B" and was hospitalized for six months due to increased alpha-fetoprotein. Magnetic resonance imaging (MRI) and computed tomography (CT) revealed a 63x 90 mm mass in segments V and VI of the liver, with thrombosis in the right branch of the portal vein. Following the patient's laparoscopic lobectomy and cholecystectomy, sarcomatoid cholangiocarcinoma of the right side of the liver was discovered by histopathological and immunohistochemical examinations. This case report seeks to increase understanding of intrahepatic sarcomatoid cholangiocarcinoma and its diagnosis while reducing the occurrence of clinical misinterpretation.
A multi-stage feature fusion defogging network based on the attention mechanism
Authors: Song Yuqin , Zhao Jitao , Shang Chunliang
Published: March 2023

This study suggests an effective multi-stage feature fusion defogging network based on an attention mechanism for the problem of problematic defogging and picture color distortion in complicated surroundings with hazy images. To create a multi-branch defogging network, the model integrates several attention techniques to create various sorts of branching network architectures. The image's spatial details and contextual information are supplemented and merged based on the recovered image feature information of different network branches to increase the effectiveness of the network model. The stage attention fusion mechanism created among several network branches can lessen the loss of image data during feature extraction and improve the effectiveness of the image-defogging operation. The experimental results demonstrate that the proposed algorithm has superior defogging performance in both synthetic and real-world scene datasets and performs more admirably in terms of accuracy compared to other sophisticated algorithms, particularly in the Reside and O-Haze datasets. The PSNR metrics on the Reside and O-Haze datasets are improved by 1.58 dB and 1.61 dB, respectively, compared to the best-advanced technique suggested in this study, and the SSIM metrics on the O-Haze dataset are improved by 3.4%.
In vitroantifungal activity of polymeric nanoparticles loaded with the methanolic extract of Euphorbia tirucalli
Authors: Heya Michel Stéphane , -Star Maria Julia verde , Rivas-Morales Catalina , García-Hernández David Gilberto , Robledo-Leal Efrén , Galindo-Rodríguez Sergio Arturo
Published: March 2023

The therapeutic potential of medicinal plants is known as an alternative in treatment of human affections; in effect, the conventional application of these medicinal sources has several limitations like low bioavailability, solubility, and stability, which affect its pharmacological efficacy. In recent decades, extraordinary advances have been made in new drug delivery systems using nanocarriers. This work consisted in determining the in vitro antifungal activity of the methanolic extract of Euphorbia tirucalli formulated in polymeric nanoparticles. The antifungal activity was determined by the microdilution method in 96-well microplates, applying nanoparticles loaded with plant extract (NP-Ext) obtained by nanoprecipitation on clinical isolates of Trichophyton rubrum and T. interdigitalis. Regarding the nanoparticles, the lots used did not present significant differences in their physicochemical characteristics, with a size of 91.885 ± 1.621nm, polydispersity index of 0.152 ± 0.025 and Z-potential of -6.047 ± 0.987. The quantification of the extract in the polymeric matrix was determined by infrared spectroscopy (FT/IR), where an efficiency and encapsulation percentage of 22.15 ± 0.82 and 2.95 ± 0.11, respectively, were obtained. The in vitro antifungal activity of the crude and formulated extract was obtained calculating the Minimum Inhibitory Concentration (MIC) of each one; a MIC of 125 µg/mL was obtained against T. rubrum and T. interdigitaliswith the crude extract, while a MIC value of 55.55 and 0.1 µg/mL was obtained with NP-Ext, respectively, against these same. Conclusions: biological activity is closely linked to the phytochemical profile of the extract; while the improvement of said potential with the NP-Ext with the dosage form was directly related to the physicochemical characteristics of the nanocarrier.
The manufacturing technique and principles for determining bearing capacity of piles
Authors: Aslanov Latif F.
Published: March 2023

Large section bored piles are widely used in the various kinds of buildings. In the present article the manufacturing technique and principles for determining the bearing capacity of large section bored piles with a “hard core” were considered. Technological parameters of large section bored piles with a “hard core” are given in manufacturing in urban area hear existing buildings, and structures and also in the construction of offshore structures. The data on determination of bearing capacity of single bored piles with a “hard core” are discussed. It was established that these piles bear much larger horizontal and vertical loads, and are the most cost effective than precast and bored piles.
Research on intelligent vehicle path tracking control based on preview distance optimization
Authors: Ye Qing , Huang Rang , Zhang Yao , Wang Ruochen , Chadli M. , Chen Long
Published: March 2023

This paper proposes an intelligent vehicle lateral-vertical cooperative control method based on optimized preview distance to address the coupling and conflict issues between the path tracking system and the handling stability in the process of controlling the motion of intelligent vehicles. To begin with, an intelligent vehicle path tracking control system based on expected yaw velocity has been designed by establishing a three-degree-of-freedom dynamic model for intelligent vehicles. Then, we analyzed the mechanism by which changes in vehicle speed, road curvature, and preview distance affect the accuracy of vehicle path tracking and handling stability. Considering the "human-vehicle-road" system in intelligent transportation systems, critical values for collision and instability were set. Furthermore, we designed a proactive optimization method for preview distance under different working conditions, using an optimization algorithm to improve path tracking accuracy while ensuring vehicle stability, based on the lateral displacement deviation and lateral lateral orientation deviation representing the accuracy of path tracking, as well as the lateral acceleration representing handling stability. Finally, HIL platform test was conducted. The simulation and test results show that the optimized path tracking algorithm reduces lateral deviation to as low as 0.05 meters, and the stability constraint control in the algorithm can be triggered promptly even under extreme conditions. The research findings provide a theoretical reference for the lateral and vertical coordinated control of intelligent vehicles in the future.
Enhanced Collaborative Filtering Recommendation Model for Graph Neural Networks Based on Meta-Paths
Authors: Fischer Benjamin , Brown Ethan , Perez Maria , Sanchez Andrew
Published: March 2023

With the development of web information technology, recommendation systems are widely used in social media networks, news delivery, and shopping platforms. Collaborative filtering (CF) is one of the main methods in recommendation systems. In recent years, the graph convolutional neural network (GCN) has emerged as the hottest research method in the current recommendation system due to its powerful ability to learn embedding representations on graph structures. Although graph convolutional neural networks have been recognized as having significant advantages in recommendation tasks, the proposed GCN-based recommendation models have generally neglected two aspects. The graph convolution layer of most models does not take full advantage of the covariance signals of higher order neighbors. For example, GCMC only uses the signal update node inlay of the 1st order neighborhood. The graph convolution layer of existing models pays little attention to the impact of different user opinions on the recommendation results when propagating and aggregating synergistic signals. In the recommendation scenario, the rating represents the user's opinion. To address these problems, this paper proposes an enhanced collaborative filtering algorithm for graph neural networks based on meta-paths (MPECFG). The study exploits the synergistic signals of 2nd order neighbors and user's view to improve the accuracy of graph convolutional neural networks in learning node embedding. In particular, we first construct bipartite graphs of users and items, embed their historical interactions into feature vectors, and then obtain higher-order representations of users and items by multi-layer propagation of the neural network. We experimented on public datasets and compared them with traditional algorithms to verify the effectiveness of our model.
Charakterisierung eines neuartigen Knochenersatzmaterials auf PLGA-Basis hinsichtlich Immunreaktivität, Zytokompatibilität und physikalischen Eigenschaften
Authors:   , Ondreka Muriel
Published: March 2023

Einleitung: Knochenersatzmaterialien gewinnen in der regenerativen Medizin immer weiter an Bedeutung. Polylactid-co-Glycolid (PLGA) wird als etabliertes synthetisches Biomaterial bereits vielseitig in der medizinischen Versorgung eingesetzt, häufig in Form von Mikropartikeln oder Platzhaltern beladen mit Antibiotika oder immunaktiven Zellen zur topischen Antibiotikatherapie und Freisetzung von regenerativen Zellen in einer Defektzone. Ziel dieser Studie war die Charakterisierung einer neuen Darbietungsform von PLGA auf ihre physikalischen Eigenschaften, ihre immunologische Signatur und Zytokompatibilität. Dieses Material soll den Einsatz von PLGA in Form einer porösen Membran zur Abdeckung von großen Knochendefekten ermöglichen. Material und Methoden: Das PLGA-Gemisch wurde in Form von scheibenförmigen Prüfkörpern und Membranen aufbereitet. Es wurde eine biomechanische Analyse des Materials auf Bruchfestigkeit, Biegesteifigkeit und seine Diffusionskapazität durchgeführt. Die Scaffolds wurden mit Knochenmarkstammzellen (BMC und MSC) besiedelt. Mittels MTT-Tests wurde die Lebensdauer und die Viabilität der Zellen auf der Prüfkörperoberfläche ermittelt. Die Zellen wurden durch PCR-Analyse auf osteogene Differenzierung untersucht. Zur Erfassung der immunologischen Signatur erfolgte ein Vollblutstimulationstest mit anschließender umfassender Auswertung des Sekretoms mittels Proteom Profiler-Analyse. Ergebnisse: Das Material wies eine geringe mechanische Stabilität auf. Die PLGA-Membran zeigte sich für Proteine bis 11,4 kDa durchlässig. Es konnte eine stetige Degeneration des Materials in wässrigem Milieu festgestellt werden. In der Sekretom-Analyse des Vollblutstimulationstests zeigte sich eine für die PLGAMembran charakteristische immunologische Signatur mit Aktivierung von proinflammatorischen Faktoren. Das Zellüberleben auf der Prüfkörperoberfläche nahm während des Erfassungszeitraums konstant ab, während die Zellviabiliät auf dem Wellboden stieg. Es konnte keine signifikante osteogene Differenzierung der Stammzellen festgestellt werden. Diskussion: Die schnelle Degeneration des Materials in wässriger Umgebung beeinflusste sowohl die Stabilität der Membran als auch die Zelladhäsion auf den Scaffolds negativ. Das Material wirkte dabei weder toxisch auf die Zellen, noch induzierte es eine osteogene Differenzierung. Die Analyse der Immunsignatur ließ eine frühe und starke Entzündungsreaktion nach Implantation des Materials vermuten. Schlussfolgerung und Ausblick: Während das vorgelegte PLGA-Gemisch nicht die mechanischen Eigenschaften eines gewichttragenden Knochenersatzstoffes aufweist, so lässt es sich dennoch erfolgreich mit Stammzellen beladen, die nach Implantation gezielt in der Defektzone freigesetzt werden können. Die Anregung einer starken Immunantwort kann gerade in der frühen Heilungsphase hilfreich sein. Weitere in vivo-Untersuchungen am Tiermodell sind notwendig zur Optimierung möglicher therapeutischer Anwendungen.
Zur Bedeutung von mechanischer Beatmung und Lungenversagen als Risikofaktoren im akut-auf-chronischen Leberversagen
Authors:   , Mengers Jan
Published: March 2023

Das akut-auf-chronische Leberversagen (ACLF) entsteht durch eine akute Dekompensation einer vorbestehenden Leberzirrhose mit begleitendem Multiorganversagen und ist durch eine sehr hohe Kurzzeitmortalität gekennzeichnet. Die Kriterien der European Association for the Study of Chronic Liver Failure (EASL-CLIF) definieren in diesem Zusammenhang ein Lungenversagen als Abfall des Horovitz-Quotienten unter 200mmHg oder als Abfall des Quotienten aus SpO2/FiO2 unter 214. Während Lungenfunktionsstörungen als unabhängiger Risikofaktor für Mortalität bei Patienten mit Leberzirrhose belegt sind, wurde die Bedeutung von mechanischer Beatmung und Lungenversagen bisher nicht isoliert untersucht. Ziel der Studie ist die Rolle von mechanischer Beatmung und Lungenversagen im ACLF zu analysieren und eine mögliche Unterinterpretation in den etablierten prädiktiven Modellen zu evaluieren. Es wurden Daten aus 775 Hospitalisationen mit intensivmedizinischer Behandlung am Universitätsklinikum Frankfurt von insgesamt 498 Patienten mit Leberzirrhose im Zeitraum März 2015 bis Juli 2019 retrospektiv erfasst und ausgewertet. ACLF und Organversagen wurden gemäß EASL-CLIF Kriterien definiert. Es erfolgte die statistische Analyse verschiedener Kohorten, wobei ACLF-Patienten mittels Propensity Score hinsichtlich CLIF-C ACLF Score und Geschlecht gematcht und anhand der pulmonalen Beeinträchtigung in eine dreiarmige Testkohorte bestehend aus 49 Patienten mit Lungenversagen, 49 Patienten mit Schutzintubation und 49 Patienten ohne pulmonale Beeinträchtigung aufgeteilt wurden. 216 Patienten zeigten ein ACLF bei Aufnahme, 121 wurden mechanisch beatmet und 68 hatten ein Lungenversagen. In der gematchten Kohorte (n=147) konnten Lungenversagen (HR 3,0) und mechanische Beatmung (HR 1,7) als unabhängige Risikofaktoren für eine hohe 28-Tage-Mortalität identifiziert werden. Der CLIF-C ACLF Score konnte als bestes Modell für die Vorhersage der Kurzzeitmortalität bestätigt werden (AUROC 0,81), zeigte allerdingt deutliche Schwächen in der Subkohorte der Patienten mit Lungenversagen (AUROC 0,49) und mechanischer Beatmung (AUROC 0,68). Eine Kalibrierung des CLIF-C ACLF Scores für diese beiden Risikofaktoren liefert auch in der Gesamtkohorte aller zirrhotischer Patienten eine signifikant verbesserte prädiktive Performance (AUROC 0,87; p=0,001). Mechanische Beatmung und Lungenversagen sind im Rahmen eines ACLF mit einer erhöhten Kurzzeitmortalität assoziiert und nur ungenügend in den etablierten Prädiktionsmodellen abgebildet. Die Kalibrierung des CLIF-C ACLF Scores für diese Risikofaktoren führt zu einer verbesserten Vorhersagegenauigkeit.
The impact of emotional intelligence on job performance at private hospitals: The moderating role of organizational culture
Authors: Khraim Hamza
Published: March 2023

Healthcare employees encounter work intimidation that influences their professional life. Emotional intelligence plays a significant role in employees’ success and performance. The organizational culture reflects the employees’ view of the company environment and relationships with others that are critical for attaining job performance. This study aims to investigate the impact of emotional intelligence on job performance in private hospitals and to test whether the organizational culture will moderate this relationship. To achieve this aim, the quantitative research approach is used. The sample consists of the big eight private hospitals in Amman. Using convenience sampling techniques, a structured questionnaire was used to collect data from hospital employees (nurses, physicians, and administrative workers). 700 questionnaires were distributed, and 554 were returned. 37 were incomplete, and 517 were used for further analysis. Descriptive data show that nurses enjoy higher emotional intelligence than physicians and administrative staff. The results of the main hypothesis (β = 0.805, t = 0.22.3, p < 0.00) indicate that emotional intelligence has a statistically significant effect on job performance. The testing of the four dimensions of emotional intelligence revealed a significant effect on job performance. The findings for self-emotional appraisal were β = 0.157, t = 0.14.41, p < 0.00; for others’ emotional appraisal – β = 0.238, t = 0.15.76, p < 0.00; regulation of emotions – β = 0.233, t = 0.16.19, p < 0.00; and for the use of emotions – β = 0.305, t = 0.17.30, p < 0.00.
Desenvolvimento regional e o processo de expansão das instituições de ensino superior no Brasil: Um estudo exploratório acerca dos seus impactos em município do semiárido Brasileiro
Authors: Cândido Gesinaldo Ataíde , Pontes Renata Rodrigues de Medeiros , Silva Ana Maria Vicente
Published: March 2023

As universidades têm adquirido importância nas políticas para geração do desenvolvimento regional, considerando todo um conjunto de produtos e serviços que as mesmas podem oferecer às demandas e necessidades dos seus escopos territoriais de atuação, em especial em regiões com maiores fragilidades e limitações em relação ao desenvolvimento. A partir desta consideração, o objetivo deste artigo foi analisar os impactos da instalação do Campus universitário para o desenvolvimento na região polarizada pelo município de Sumé-PB. Em termos metodológicos, trata-se de um estudo descritivo e exploratório utilizando métodos quantitativos a partir de base teórica previamente analisada. Os resultados obtidos mostram que a instalação do Campus gerou impactos positivos para o município, no entanto foram identificados alguns problemas que podem contribuir para gerar impactos negativos, dentre eles a falta de articulação da universidade com demandas municipais e regionais e uma maior vinculação entre atores sociais da universidade com demais atores de outras Instituições na região.
Plano de mobilidade urbana e os desafios para a sua elaboração: Uma análise dos municípios do estado do Rio de Janeiro
Authors: Pacifico Dayse da Silva , Silva Júnior Orivalde Soares da , Reis Marcelo de Miranda
Published: March 2023

O objetivo deste trabalho é promover uma reflexão acerca das problemáticas que surgem na elaboração dos Planos de Mobilidade Urbana no Brasil, pois, embora muitas cidades tenham colocado em prática essa proposta, para outras a formulação de planos de mobilidade urbana, comprometidos com a sustentabilidade, ainda representa um obstáculo a ser superado em termos teóricos e práticos. O foco deste estudo, portanto, é realizar uma análise em especial nos municípios do Estado do Rio de Janeiro. Para tanto, com uma metodologia baseada em uma análise descritiva e de natureza quantitativa, foi possível identificar, por intermédio de um questionário enviado aos gestores municipais, a realidade local quanto ao tema proposto. Para aplicação da metodologia e com a intenção de garantir a confiabilidade do questionário empregado, foi realizado o teste de Alfa Cronbach com os dados obtidos de 18 municípios do Estado do Rio de Janeiro e, logo após, são calculadas as frequências das respostas, além de uma análise estatística. Como resultado, buscou-se evidenciar alguns elementos importantes à discussão institucional como parte do processo de planejamento estratégico de uma mobilidade urbana mais eficiente.
Uma análise empírica das posições de economias competitivas nos rankings globais de sustentabilidade
Authors: Maia Andrei Giovani , Conte Filho Carlos Gilbert , Ferreira Elaine
Published: March 2023

Diante dos possíveis efeitos e limites do crescimento econômico, o paradigma da sustentabilidade se consolidou com uma alternativa economicamente viável, socialmente justa e ambientalmente correta de se alcançar o desenvolvimento das economias globais (CMMAD, 1988). Embora durante o século 20 os estímulos à competição e ao crescimento econômico possam ter extrapolado os limites de suporte socioambientais em âmbito global, atualmente pode-se questionar se seriam as economias menos sustentáveis mais competitivas. Com base nesta questão de pesquisa, este artigo teve como objetivo principal analisar as posições das economias mais competitivas nos principais rankings globais de sustentabilidade. A metodologia adotada envolveu uma abordagem empírica com tratamento estatístico de dados que, por meio de análises de causalidade, correlação e regressão, permitiu comparar as posições das economias mais competitivas dentro de dois importantes rankings globais de sustentabilidade referentes ao ano de 2020. Diante dos resultados obtidos, pode-se concluir que as economias mais competitivas também estão entre as economias mais sustentáveis, o que corrobora a hipótese de coexistência entre competição e sustentabilidade.
Manning's roughness coefficient in a truncated triangular open-channel flow section
Authors: Sabah Sehtal , Bachir Achour
Published: March 2023

In uniform flows, Manning's roughness coefficient n plays an important role in the calculation of the normal depth in the open channels. When calculating uniform flows in open conduits and channels, Manning's coefficient is arbitrarily chosen. This arbitrary choice is not physically justified because the coefficient n must be determined according to the parameters that influence the flow, particularly the normal depth sought. In this paper, a new method is presented to compute Manning's coefficient in a truncated triangular channel section. In the first step, the study proposes to establish the general relationship that allows computing Manning's coefficient in this type of channel. The relationship is presented in dimensionless terms, giving it a character of general validity, including the dimensionless Manning's resistance coefficient, denoted as N. The latter is shown to depend on the aspect ratio of the wetted area, the side slope of the channel, the relative roughness and the modified Reynolds number, which is physically justified since flow resistance is closely related to flow depth. In the second step, the rough model method is proposed to express Manning's coefficient when the horizontal dimension of the channel is not a given data of the problem.
Trends and Problems of the Development of the Russian Farming Sector According to the Agricultural Micro-Census of 2021
Authors: Petrikov A. V.
Published: March 2023

The priority task of modern agrarian policy is to stimulate small business in agriculture, and above all its central link – peasant (farm) farms. This requires a comprehensive analysis of the patterns and problems of their development. The article, based on the results of the Agricultural Micro-Census of 2021 published in December 2022, in comparison with the results of the AllRussian Agricultural Census of 2016, characterizes the farming sector, identifies trends and problems of its development for 2016-2021. The main conclusion is that despite the reduction in the number of farms and farmers’ access to budget subsidies, the areas of agricultural land used by them, acreage of high margin crops and cattle are increasing. There are significant differences in the development of farms in the subjects of the Russian Federation. Based on the analysis, the following measures are proposed to stimulate farms: ensuring wider access of farmers to budgetary and credit resources; strengthening the role of the federal center in state support and regulation of farms in order to equalize regional differences and form a single economic space in the agro-industrial complex; more careful consideration of farmers’ interests in conducting land policy; formation of an effective system marketing of farm products.
Neutralizing Antibody Response by Inactivated SARS-CoV-2 Vaccine on Healthcare Workers
Authors: Tandirogang Nataniel , Fitriany Evi , Mardania Nursaci , Jannah Miftahul , Dilan Bilqis Faiqotun Nabilah , Ratri Sapta Rahayuning , Prakoso Arfian Deny , Aminyoto Meiliati , Ningrum Yuliana Kartika , Fikriah Ika , Yadi Yadi
Published: March 2023

Background: Currently, the key to combat coronavirus disease 2019 (COVID-19) as a global pandemic is relying mainly on vaccination, and several factors might affect the level of protection. This study aimed to determine the quantitative increase of neutralizing antibody titer against COVID-19 and the influence of gender, body mass index (BMI), routine consumption of vitamin C, D, and E towards the neutralizing antibodies after vaccination.Materials and methods: One hundred nine health workers from various health facilities were recruited. Sinovac inactivated severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccine was used in this study. Antibody titer measurements were carried out quantitatively using electrochemiluminescence immunoassay (ECLIA) on day 14 after the first and second doses administration of the vaccine.Results: The average of antibody titers after the first and second doses were 109.1 and 191.6 U/mL, respectively. Antibody titer significantly increased (p=0.000) as much as 82.5 U/mL from the first to the second dose. There was a significant difference in the increase in antibody titer between respondents who consumed vitamin E regularly and those who did not (p=0.036). Routine consumption of vitamin C and D, gender, and BMI did not affect the increase in neutralizing antibody titer with p-values of 0.983, 0.337, 0.186, and 0.424, respectively.Conclusion: Routine consumption of vitamin E is associated with post-SARS-CoV-2 vaccination neutralizing antibody response. Gender, BMI, and the routine consumption of vitamin C and D have no association with the immune response.Keywords: COVID-19, neutralizing antibody, inactivated SARS-CoV-2 vaccine
IMPLANTAÇÃO DO SISTEMA ELETRÔNICO DE INFORMAÇÃO (SEI) NO ESTADO DE ALAGOAS
Authors: Lima Paulo Ricardo Silva , Dos Anjos Vagner Felisdório
Published: March 2023

Tendo a eficiência como tema transversal, este artigo apresenta o contexto gerencial do Sistema Eletrônico de Informações (SEI), desde seu desenvolvimento pelo Tribunal Regional Federal da 4ª Região (TRF4) até sua implantação em Alagoas, especificamente nos órgãos do poder executivo da administração direta e indireta, tendo a SEPLAG/AL como Órgão Gestor e o ITEC/AL como Órgão Técnico. Com base nisso, são apresentadas as principais funcionalidades e interface do sistema a fim de verificar os possíveis benefícios oriundos da sua implementação para promoção da eficiência, em especial para os órgãos do executivo em Alagoas. Para isso, é realizada pesquisa que utiliza a abordagem qualitativa e quantitativa, apoiada pelo método indutivo, bem como a abordagem explicativa, baseada na análise documental e levantamento de dados. A partir desse panorama, percebe-se que a rastreabilidade, a segurança, a economia e a facilidade de uso se apresentam como os principais aspectos do sistema levando em consideração o estágio de sua implementação no ambiente analisado. Isso se dá pelo fato da implantação do SEI ser feita por meio de módulos e, por isso, algumas funcionalidades do SEI não estão disponíveis tendo em vista seu status de sua implementação no Poder Executivo do Estado de Alagoas. Ademais, esses pontos levantados, denotados como vantagens, decorrem da implantação do SEI em Alagoas e apresentam relação com o estímulo à eficiência na gestão pública.
VK2 Promotes Osteogenic Differentiation of BMSCs against High Glucose
Exposure via Modulation of Intracellular Oxidative Stress
Authors: Fang Wenlai , Lv Yiyun , Jin Shuqing , Zhu Zheng , Chen Yunzhen
Published: March 2023

Introduction:

Diabetic osteoporosis (DOP) has gradually gained public attention. The clinical manifestations
of DOP include bone mass loss, bone microstructural damage, and increased bone fragility.

Methods:

Intracellular reactive oxygen species (ROS) production was significantly increased under high glucose
(HG) conditions, with deleterious effects on bone mesenchymal stem cells (BMSCs) proliferation and osteogenic
differentiation. Vitamin K2 (VK2) has been demonstrated to promote bone formation both in vitro and
in vivo.

Results:

However, its potential role in diabetes-induced osteoporosis remains unelucidated. This study aims to
verify whether VK2 treatment could relieve the deleterious effects of high glucose on BMSCs and delay the progression
of osteoporosis. The results revealed that the HG environment downregulated the expression of osteogenesis-
related proteins.

Conclusion:

Correspondingly, VK2 treatment reversed the osteogenic phenotype of BMSCs under HG conditions.
In addition, using an established diabetes-induced osteoporosis rat model, we found that VK2 administration
could restore bone mass and microstructure. In conclusion, our results provide a promising therapeutic option
in the clinical treatment of DOP.
PERSEPSI PETANI TERHADAP KONSEP PHT DALAM MENGENDALIKAN PENYAKIT TANAMAN PADI DI KABUPATEN BEKASI, JAWA BARAT
Authors: Handayani Chika Gianni , Abadi Abdul Latief
Published: March 2023

Praktik budidaya tanaman dan pengolahan lahan yang digunakan petani di lahannya biasanya dilakukan berdasarkan ilmu yang didapatkan, seperti belajar bertani turun temurun dari orang tua, belajar secara mandiri, belajar melalui diskusi sesama petani dan mengikuti pelatihan bertani. Hal tersebut menyebabkan petani memiliki persepsi yang berbeda-beda terhadap suatu ilmu pertanian. Sehingga setiap lahan pertanian memiliki kriteria yang berbeda seperti varietas tanaman yang digunakan, sistem tanam, pengendalian OPT, kondisi lingkungan dan lainnya. Penelitian ini bertujuan untuk mengetahui persepsi petani terhadap konsep PHT dalam mengendalikan penyakit tanaman padi di daerah sentra produksi padi di Kabupaten Bekasi, Jawa Barat. Penelitian dilakukan pada bulan September 2021 di beberapa lahan padi di Kabupaten Bekasi. Penelitian ini merupakan penelitian eksplorasi dengan metode survei, yaitu identifikasi penyakit tanaman padi dan wawancara dengan petani pemilik atau pengolah lahan untuk mengetahui persepsi petani terhadap konsep PHT dalam mengendalikan penyakit tanaman padi. Hasil penelitian menunjukkan bahwa persepsi petani terhadap PHT dapat mempengaruhi cara petani dalam pengolahan lahan tanaman padi. 3 dari 4 petani yang menjadi responden, memiliki persepsi yang kurang baik mengenai PHT dan memilih untuk tidak menerapkannya.
KEANEKARAGAMAN DAN KELIMPAHAN HAMA PASCAPANEN DI GUDANG BERAS PERUM BULOG KANTOR CABANG CIANJUR
Authors: Rianti Putri Setya , Astuti Ludji Pantja
Published: March 2023

Penelitian ini bertujuan untuk mengkaji keanekaragaman dan kelimpahan hama pascapanen yang menginfestasi beras di gudang Perum Bulog Kantor Cabang Cianjur. Penelitian dilakukan pada bulan Januari sampai dengan April 2022 di gudang beras milik Perum Bulog Kantor Cabang Cianjur yang terletak di Jl. Ir. H. Juanda No. 110, Desa Bojong Herang, Kecamatan Cianjur, Kabupaten Cianjur, Jawa Barat. Identifikasi serangga dilakukan di Laboratorium Hama Tumbuhan, Departemen Hama dan Penyakit Tumbuhan, Fakultas Pertanian, Universitas Brawijaya. Penelitian dilakukan dengan pengambilan sampel beras, pemasangan perangkap cahaya, perangkap lekat kuning, perangkap jatuhan, perangkap umpan, dan perangkap kubah di dalam gudang. Data dianalisis menggunakan perangkat lunak R statistics versi 4.2.0. Hasil penelitian menunjukkan bahwa nilai Indeks Keanekaragaman (H’) adalah 0,15 yang berarti bahwa keanekaragaman hama pascapanen di gudang beras rendah dan ekosistem gudang tidak stabil. Terdapat tujuh spesies serangga hama yang ditemukan yaitu Sitophilus oryzae, Rhyzopertha dominica, Tribolium castaneum, Alphitobius laevigatus, Cryptolestes pusillus, Cadra cautella, dan Liposcelis sp.. Nilai Indeks Dominansi (D) termasuk kategori tinggi dengan nilai 0,94 yang berarti bahwa terdapat spesies yang mendominasi yaitu Liposcelis sp.. Kelimpahan hama pascapanen berfluktuasi dari minggu pertama sampai minggu terakhir pengamatan.
PENGARUH TANAMAN REFUGIA TERHADAP TINGKAT KERAGAMAN PARASITOID HYMENOPTERA HAMA KEPIK HIJAU PADA TANAMAN KEDELAI
Authors: Harianto Irfan , Haryadi Nanang Tri
Published: March 2023

Mikrohabitat merupakan suatu kondisi lingkungan yang cocok untuk ditempati oleh beberapa jenis organisme seperti serangga musuh alami maupun serangga hama tanaman. Salah satu upaya menciptakan mikrohabitat adalah dengan memanfaatkan tanaman refugia. Penggunaan tanaman refugia bertujuan untuk meningkatkan keberadaan dari musuh alami seperti parasitoid. Perlakuan yang digunakan pada penelitian ini yaitu penanaman tanaman refugia Turnera ulmifolia, Melampodium divaricatum, Sesamum indicum dan kontrol. Rancangan percobaan menggunakan RAK dengan 6 kali ulangan. Hasil penelitian menunjukkan bahwa penggunaan tanaman refugia dapat meningkatkan keberadaan musuh alami seperti parasitoid Hymenoptera. Penggunaan tanaman refugia Melampodium divaricatum merupakan perlakuan yang terbaik dengan kehadiran 70 individu parasitoid yang tergolong dalam 14 famili.
UJI NILAI PROPAGUL JAMUR ARBUSKULA MIKORIZA INDIGENOUS TANAH HUTAN CANGAR DAN HUBUNGANNYA DENGAN C-ORGANIK, P TOTAL DAN P TERSEDIA TANAH
Authors: Muslimin Syamsul Huda Harisul , Syib’li Muhammad Akhid , Sektiono Antok Wahyu
Published: March 2023

Hutan Cangar termasuk salah satu hutan yang ada di Indonesia yang memiliki banyak makro serta mikroorganisme yang hidup di dalamnya, salah satunya yaitu mikoriza. Mikoriza termasuk golongan jamur yang mampu berasosiasi dengan perakaran tanaman yang ada di hutan. Salah satu jenis mikoriza yaitu Vesikular Arbuskular Mikoriza (VAM). Dalam menginfeksi tanaman, VAM menggunakan propagul yang terdiri dari spora mikoriza itu sendiri, tanah yang terinfestasi dan akar yang terinfeksi oleh mikoriza. VAM berperan dalam siklus karbon karena mampu mengambil karbon dari tanaman untuk bertahan hidup serta mempengaruhi ketersediaan unsur P di tanah karena membantu tanaman menyerap unsur P dari tanah. Penelitian yang dilakukan meliputi pengambilan sampel tanah, penanaman tanaman kenikir, pewarnaan akar dan perhitungan nilai MPN. Hasil penelitian didapatkan bahwa nilai propagul jamur arbuskula mikoriza sebesar 12.961,897 propagul per gram dan berpengaruh terhadap kandungan C-Organik yang tinggi, P total sedang dan P tersedia tinggi. Tingginya nilai C-Organik ini dapat dipengaruhi karena mikoriza mengambil karbon dari tanaman untuk bertahan hidup dan sebagian karbonnya dialirkan ke tanah untuk membantu mikroba dalam mendekomposisi bahan organik yang mana akan menghasilkan karbon di tanah. Sedangkan tingginya kandungan P tersedia dapat disebabkan karena mikoriza mampu merubah kandungan P dari kondisi tidak tersedia menjadi tersedia dengan bantuan enzim fosfatase.
Student Competency Association Analysis For Learning Evaluation Using Apriori Algorithm
Authors: Dewi Sri Mulyani Evi , Purnama Putra Yuda , Badar Sambani Egi , Siti Sundari Shinta , Mufizar Teuku , Satrio Nugraha Muhamad
Published: March 2023

Evaluation activities as a process in a learning program are one of the keys to improving the quality of education that will be accepted by students in learning. Therefore it is important for a teacher in how to understand the lack of learning given to students. Based on this, an analysis was carried out using the Association method with the Apriori Algorithm in finding relationships in the competency value data for each subject. In the Apriori method, it will produce a value that will determine the formation of the pattern. The data used is competency data based on student grades of English class 11 odd semester year class 2019 - 2020 SMK Ar - Rizqi Bina Insani with a total of 108 records with a maximum itemset of 3 itemset. The results of this association analysis produce a relationship between competencies that appear simultaneously, so that it can be used as an evaluation of learning for teachers as a learning improvement strategy for students based on the competence of each subject.
Developing Mobile Career Learning Model for Electronics Engineering Vocational High School
Authors: Nurdianah Evi , Sudira Putu
Published: March 2023

The objective of this study is to develop a mobile career learning model for electronics engineering vocational high school and reveal the feasibility of the developed mobile career learning model to develop electronics engineering vocational student's competencies. This research utilized research and development method that refers to the Holistic 4D model, includes four stages of development: define, design, develop and deploy with three levels of holistic design and an interactive cycle, namely analysis, design, and evaluation. The define stage includes the performance analysis observations and instructional needs assessment. The design stage includes the design evaluation stage which involves expert with the background of lecturers, principals, teachers, career experts, software experts and successful alumni. The develop stage involves a review of material experts and media experts as well as a limited trial involving students and teachers of electronics engineering vocational high school. The data collection used observation sheets and questionnaires that have been validated by experts. The data analysis used the descriptive method. The results of the study are as follows. (1) The developed mobile career learning model integrates vocational learning activities and career guidance by utilizing information technology in the form of mobile career learning media applications. (2) The developed mobile career learning model is feasible and can be used for career development of students with electronics engineering competence.
Monitoring and Controlling Temperature Egg Incubator Prototype Based LoRa Communication
Authors: Afandi Mas Aly , Purnomo Fadhila Karin , Rochmanto Raditya Artha , Purnama Sevia Indah
Published: March 2023

Poultry industries encounter problem in produce day old chicken (DOC). Poultry industries usually produce DOC using egg incubator. Egg incubator must have high accuracy in reading environment temperature inside the machine. The temperature environment inside the egg incubator machine needs to keep in range 36°C - 40°C. On the other hand, hatcheries and chicken coop usually not in one place. Poultry industries require applied technology to solve this problem. This problem can be solved by using internet of things. But internet of things can be so expensive. This research is aim to implement monitoring and controlling temperature inside egg incubator prototype while using low-cost communication technology. Research result showed that the control system could maintain egg incubator prototype temperature in optimal range with an accuracy of 99,63%, 99,83%, 99,97%,99,64%, and 99,37% when reading a temperature of 36°C, 37°C, 38°C, 39°C, and 40°C respectively. This research implements Long Range (LoRa) technology for monitoring system. Different with internet of things technology, point to point LoRa communication does not needs payment to communicate but still provide wide area communication. According to research result, point to point LoRa communication provide good performance in sending temperature data in range area 50m, 100m, 150m, 200m, 250m, and 300m with good average Receive Signal Strength (RSSI). This research can conclude proposed egg incubator can keep temprature in optimal range. Proposed incubator also can communicate properly to send data temperature for monitoring temperature.
Implementation of AHP and Black Box Testing to the Development of an Information System for Assessing the Feasibility of BUMDES Submissions
Authors: Hidayat Hari Toha , Husaini Husaini , Prihatin Nanang , Radhiyatammardhiyyah Radhiyatammardhiyyah
Published: March 2023

The existence of institutional village enterprises (BUMDES) has never been adequately monitored in terms of the growth of village-owned businesses in each village. According to the data, there are 17 BUMDES in the Muara District that have been inactive for the most part. Due to the difficulty of monitoring the progress of BUMDES, a significant number of them have become stalled or even inactive. In addition, many BUMDES managers are frequently unprepared to operate the newly opened business. Readiness in terms of the quality of human resources also affects the formation of BUMDES. Consequently, the objective of this study is to facilitate the monitoring of business developments carried out by BUMDES actors in their respective villages, thereby facilitating the feasibility assessment of BUMDES. Aside from that, the purpose of this study is to determine the viability of applying for BUMDES as one of the requirements for obtaining a recommendation from the village head for submission to the Village Ministry.  The feasibility analysis employs the AHP method with multiple parameters, including business age, business type, and business capital. According to research findings with applications, several BUMDES are declared unfit, while others are declared feasible. BUMDES with declared eligibility has AHP values ranging from 0.382 to 0.619. Meanwhile, BUMDES that are unworthy receives AHP values ranging from 0.235 to 0.239. It can also be determined based on the weight of each criterion as to whether or not it is appropriate for BUMDES. While the results of black box testing for the system's feasibility using 10 types of testing, including Equivalence Partitioning, Boundary Value Analysis/Limit Testing, Comparison Testing, Sample Testing, Robustness Testing, Behavior Testing, Performance Testing, Requirement Testing, Endurance Testing, and Cause-and-Effect Relationship Testing. Based on the test results, the system is 100% feasible to be used by users.
Comparison of Web 2.0 Use on State University Websites in Indonesia and Top World Universities Related to Webometric Ranking
Authors: Jati Handaru
Published: March 2023

The present work determines the presence in the web 2.0 that twenty universities had through their educational portals. The universities are selected according to the Webometrics ranking (the ten best located in Indonesia and the best located worldwide) to identify what Web 2.0 tools they use. This study explores the educational portals of the twenty selected universities to determine which Web 2.0 tools they use and variables of the tools found will be assessed. The  study only considers those Web 2.0 tools which are linked to the websites of universities. Of the two most used tools, the relevant indicators are quantified from Youtube "Subscribers" and "Views " and Twitter "tweets" following", and "followers". Afterward, the results are shown and analyzed to establish possible relationships between the indicators of each tool. The results reflect the heterogeneous and, in many cases, polarized presence that universities had on web 2.0 through their educational portals. We hope that the work will help universities have a verifiable reference instrument to develop their academic communication strategies through these tools on the way to a 2.0 university model.
Strengthening students’ character through TPACK-based learning
Authors: Chotimah Umi , Yanzi Hermi , Kurnisar Kurnisar , Faisal Emil El , Yusuf Muhammed , Susanti Emi
Published: March 2023

This study aims to describe strengthening students’ character through TPACK-based learning. It’s implemented in Pancasila and Civics Education teaching and learning process at SMA Negeri 1 Palembang, one of favorite high school in Palembang city.   Although this school has been recognized as a superior school and is the oldest public high school in the city of Palembang, but this school is still focused on students’ character. The data collection used in this study were observation, questionnaire, and documentation. It’s implemented by applying TPACK-based learning with teaching materials which was held four times. Data were analyzed by comparing the results of observations before and after learning. Based on the result and discussion, it can be concluded that strengthening students' character can be improved through the application of TPACK-based learning. The TPACK-based learning includes the teacher's ability to design and applied technology (a learning video developed, power point media, values cases), pedagogy (models of teaching, teaching approaches, teaching strategy and methods), and content knowledge that integrates characters, namely religious values, nationalism, independence, integrity, and cooperation the course values relevant to the learning objectives and indicators of basic competencies so that it  makes teaching and learning process can strength the students’ character and very interactive, joyful and achieve learning objectives.
The use of google sites in civic education learning in the Covid-19 pandemic era
Authors: Permatasari Mitra , Murdiono Mukhamad , Puspitasari Chandra Dewi
Published: March 2023

The Covid-19 pandemic has had an impact on the world of education and requires online learning in the learning process, especially in Civic Education. The purpose of this study is to describe the planning and organization of the use of google sites in Civics learning, strategies for using google sites, as well as the implementation and evaluation of the use of Google sites. This study uses a qualitative descriptive research method. Data collection techniques are interviews, observations, and documentation during the learning process. The results showed that the use of google sites in Civics learning in the Covid-19 pandemic era included planning and organizing by designing steps or stages to achieve goals. Then the strategy for using Google sites is to develop online learning media in the Covid-19 pandemic era by utilizing digital-based multimedia technology. Furthermore, the implementation and evaluation of the use of google sites is the interaction between lecturers and students online on google sites such as observing, asking, exploring, associating, and communicating activities. The use of google sites in online Civics learning in the Covid-19 pandemic era can be an effective and efficient learning media, using Google sites as an alternative media lecturers can use in learning activities in the Covid-19 pandemic era. Online learning on civic education uses google sites where students tend to be more active in discussions.
Civic culture: The marriage values of the Catholic Church on the Dayak Tamambaloh marriage tradition
Authors: Efriani Efriani , Dewantara Jagad Aditya , Sulistyarini Sulistyarini , Sihaloho Nahot  Tua Parlindungan , Afandi Afandi , Soeharto Soeharto
Published: March 2023

This study has been motivated by the phenomenon of married life facing various challenges of the times. Therefore, this study has taken the topic of the importance of morals in married life, especially in realizing a harmonious and lasting family life. By focusing on Dayak Tamambaloh in Santo Martinus Parish, Sintang Diocese. This study aims to explore the values of marriage customs in light of the moral teachings of the Catholic Church. Dayak Tamambaloh views marriage as a lifelong union of a man and a woman that lasts a lifetime. This Tamambaloh Dayak marriage custom is manifested in the prohibition of adultery, the ideal form of marriage that is heterosexual and has children, and the ban on divorce. The marriage custom of the Dayak Tamambaloh is in line with the nature of marriage in the Catholic Church, which is monogamous and indivisible. This phenomenon has shown the Tamambaloh Dayak as an ethnic group that can adapt their lives to the morality and spirituality of the Catholic Church. Likewise, the Catholic Church has demonstrated a high appreciation for the noble values of the Tamambaloh Dayak culture.