bluuebunny/crossref_metadata_2025 huggingface dataset:
The Hokkiens in early modern Hoi An, Batavia, and Manila: Political agendas and selective adaptations
Authors: Chen Boyi
Published: April 2021

This article focuses on how political agendas and existing societal circumstances in three Southeast Asian regions impacted the early history of immigrant Hokkiens, one of the most prominent Chinese ethnic groups. The article argues that different Hokkien actions and their outcomes were shaped or highly influenced by the prevailing agenda and political struggles of local rulers and/or colonial powers, resulting in selective adaptive behaviour as ‘challengers’ or ‘cooperators’. There were prominent immigrant Hokkien challengers to the status quo in Manila and elsewhere in the Philippine Islands, but both cooperators with the prevailing status quo and challengers to it were common in Hoi An, Vietnam. By contrast, cooperators were conspicuous in Batavia and in the colonial Dutch East Indies.
First record of clasper malformation of Pseudobatos buthi (Chondrichthyes: Rhinobatidae) in the Gulf of California
Authors: Soto-López Katherin , García-Vázquez Gabriela , Martínez-Ayala Julio C. , Galván-Magaña Felipe , Ochoa-Báez Rosa I.
Published: April 2021

Elasmobranchs in the Gulf of California have been found with malformations, probably originated during embryonic development or caused by environmental anomalies and pollution associated with intense mining activity in the region. Clasper malformations are reported for the first time in two specimens of Pseudobatos buthi, a species recently described from the Gulf of California. The function of the claspers was not affected by the size difference, because specimens presented the distinctive characteristics of an adult individual. The reproductive system did not show any malformation, with symmetrical testes. Histological analysis of the testes revealed a normal spermatogenic development. To elucidate the causes and to detect a possible effect of the morphological malformations due to high levels of heavy metals, trace concentration values (cadmium, copper, iron, manganese, silver, lead and zinc) were determined in muscle and liver. Cadmium and lead concentrations in the muscle of the two specimens were below the permissible limit for human consumption (<0.05 mg kg−1); however, iron and zinc presented high values (0.455, 4.024 mg kg−1 in muscle and 21.931, 3.694 mg kg−1 in liver respectively). Mining activity and heavy metal pollution in the sampling area may have caused the malformations, which might be attributed to the high values of iron and zinc discovered in the muscle and liver.
The Battle for Post-Habsburg Trieste/Trst: State Transition, Social Unrest, and Political Radicalism (1918–23)
Authors: Bresciani Marco
Published: April 2021

In spite of the recent transnational turn, there continues to be a considerable gap between Fascist studies and the new approaches to the transitions, imperial collapses, and legacies of post–World War I Europe. This article posits itself at the crossroads between fascist studies, Habsburg studies, and scholarship on post-1918 violence. In this regard, the difficulties of the state transition, the subsequent social unrest, and the ascent of new forms of political radicalism in post-Habsburg Trieste are a case in point. Rather than focusing on the “national strife” between “Italians” and “Slavs,” this article will concentrate on the unstable local relations between state and civil society, which led to multiple cycles of conflict and crisis. One of the arguments it makes is that in post-1918 Trieste, where the different nationalist groups contended for a space characterized by multiple loyalties and allegiances, Fascists claimed to be the movement of the “true Italians,” identified with the Fascists and their sympathizers. Accordingly, while targeting the alleged enemies of the “Italian nation” (defined as “Bolsheviks,” “Austrophiles,” and “Slavs”), they aimed to polarize the Italian-speaking community along different political fault lines to reconfigure relations between the state and civil society.
‘Mehn! This wins the award’
Authors: Unuabonah Foluke Olayinka
Published: April 2021

Nigerian English (NigE) is a second language (L2) variety of English which has been domesticated, acculturated, and indigenised (Taiwo, 2009: 7; Jowitt, 2019: 26), due to its co-existence with about five hundred indigenous Nigerian languages (see Eberhard, Simons & Fennig, 2019). It is the language of education, governance, law, the media, and formal financial transactions in Nigeria. Based on Schneider's (2003: 271) Dynamic Model of the evolution of the New Englishes, NigE can be located at the late stage of nativisation, while recent studies show that it is on the verge of entering endonormative stabilisation (Gut, 2012: 3; Unuabonah & Gut, 2018: 210). Although NigE is an L2, there is a growing number of young people who speak it as a first language (L1; see Jowitt, 2019: 16; Onabamiro & Oladipupo, 2019). NigE includes sub-varieties which are classified based on different factors such as region/ethnicity, and educational attainment (Banjo, 1971; Jibril, 1986; Udofot, 2003). Although Udofot (2003: 204) suggests that the sub-variety used by Nigerians who have been educated in tertiary institutions should be taken as the standard variety, Jowitt (1991: 47) opines ‘that the usage of every Nigerian user is a mixture of Standard forms’ and non-standard forms. The data used in this paper are a mix of both standard and non-standard forms.
Spatial conservation prioritization considering socioeconomic costs and degradation conditions in the Southwest China Biodiversity Hotspot
Authors: Fu Wei , Ding Qi , Sun Zhe , Xu Tao
Published: April 2021

There have been calls for the expansion of protected areas (PAs) to tackle the ongoing biodiversity loss, yet it is unclear where future PAs might help to protect biodiversity in degraded landscapes under the conservation planning principles of complementarity, connectivity and cost-effectiveness. Our conservation goal is to increase the PA network coverage to up to 30% of the landscape of the Zhangjiang River Basin for target species in the karst area of southwest China, a global biodiversity hotspot.Zonation 4GUIwas used to evaluate the adequacy of current PAs and to strategically expand PAs while maximizing the coverage of target species and considering ecological integrity and socioeconomic activities. The results show that significant habitat degradation has occurred across 77.9% of the basin. The current PAs cover 6.3% of the site and represent 8.7% of the total distribution of key species. With regards to the threshold of protection of 30% of the area, protecting an additional 27.2% of the site under an ecological integrity prioritization scenario and a scenario of the socioeconomic costs involved in iteration would cover 93.5% and 80.4% of the ranges of the key species, respectively. Our results can be used to inform the upcoming actions associated with karst area conservation-related policies.
Estimating the effects of reopening of schools on the course of the epidemic of COVID-19
Authors: Massad Eduardo , Amaku Marcos , Tadeu Covas Dimas , Fernandes Lopez Luis , Coutinho Francisco Antonio Bezerra
Published: April 2021

In this paper, we present a method to estimate the risk of reopening of schools illustrated with the case of the State of São Paulo, Brazil. The model showed that, although no death of children would result from the reopening of the schools in the three cities analysed, the risk of asymptomatic and symptomatic cases and secondary cases among teachers, school staff and relatives of the children is not negligible. Although the epidemic hit different regions with different intensities, our model shows that, for regions where the incidence profile is similar to the cities analysed, the risk of reopening of schools is still too high. This in spite of the fact that incidences in these cities were declining in the period of the time considered. Therefore, although we cannot extend the result to the entire country, the overall conclusion is valid for regions with a declining incidence and it is even more valid for regions where incidence is increasing. We assumed a very conservative level of infection transmissibility of children of just 10% as that of adults. In spite of the very low level of transmissibility is assumed, the number of secondary cases caused by infected children among teachers, school staff and relatives varied from 2 to 85. It is, therefore, too soon to have any degree of confidence that reopening of schools before the advent of a vaccine is the right decision to take. The purpose of our model and simulations is to provide a method to estimate the risk of school reopening, although we are sure it could be applied as a guide to public health strategies.
Immunogenicity and safety of a quadrivalent meningococcal tetanus toxoid-conjugate vaccine administered concomitantly with other paediatric vaccines in toddlers: a phase III randomised study
Authors: Dhingra M. S. , Namazova-Baranova L. , Arredondo-Garcia J. L. , Kim K.-H. , Limkittikul K. , Jantarabenjakul W. , Perminova O. , Kobashi I. A. R. , Bae C.-W. , Ojeda J. , Park J. , Chansinghakul D. , B'Chir S. , Neveu D. , Bonaparte M. , Jordanov E.
Published: April 2021

Invasive meningococcal disease has high morbidity and mortality, with infants and young children among those at greatest risk. This phase III, open-label, randomised study in toddlers aged 12–23 months evaluated the immunogenicity and safety of meningococcal tetanus toxoid-conjugate vaccine (MenACYW-TT), a tetanus toxoid conjugated vaccine against meningococcal serogroups A, C, W and Y, when coadministered with paediatric vaccines (measles, mumps and rubella [MMR]; varicella [V]; 6-in-1 combination vaccine against diphtheria, tetanus, pertussis, polio, hepatitis B and Haemophilus influenzae type b [DTaP-IPV-HepB-Hib] and pneumococcal conjugate vaccine [PCV13])(NCT03205371). Immunogenicity to each meningococcal serogroup was assessed by serum bactericidal antibody assay using human complement (hSBA). Vaccine safety profiles were described up to 30 days post-vaccination. A total of 1183 participants were enrolled. The proportion with seroprotection (hSBA ≥1:8) to each meningococcal serogroup at Day 30 was comparable between the MenACYW-TT and MenACYW-TT + MMR + V groups (≥92 and ≥96%, respectively), between the MenACYW-TT and MenACYW-TT + DTaP-IPV-HepB-Hib groups (≥90% for both) and between the MenACYW-TT and MenACYW-TT + PCV13 groups (≥91 and ≥84%, respectively). The safety profiles of MenACYW-TT, and MMR + V, DTaP-IPV-HepB-Hib, and PCV13, with or without MenACYW-TT, were generally comparable. Coadministration of MenACYW-TT with paediatric vaccines in toddlers had no clinically relevant effect on the immunogenicity and safety of any of the vaccines.
The Transatlantic Dynamics of European Cultural Diplomacy: Germany, France and the Battle for US Affections in the 1920s
Authors: Piller Elisabeth Marie
Published: April 2021

The article explores the role of cultural diplomacy in Weimar Germany and France's competing efforts to win the sympathies and support of the United States after the First World War. In the post-war United States, both France and Germany used cultural initiatives to pursue their opposing visions of the new international order: France to maintain and extend wartime cultural alliances beyond the armistice and implement the provisions of the peace treaty; Germany to overturn these very alliances and build a desirable transatlantic ‘friendship’ in line with its efforts to revise the Versailles Treaty. By focusing on the Franco–German rivalry for US affinities, the article calls attention to the transatlantic dynamics of interwar cultural diplomacy. It shows that the emergence of German cultural diplomacy was strongly shaped by French competition for the affections of politically isolationist Americans and that, in general, the rapid expansion of cultural diplomacy in interwar Europe arose from mutual feelings of crisis, starkly competing ambitions as well as the rapid circulation of ideas and practices.
Cartographies of catastrophe: mapping World War II destruction in Germany and Poland
Authors: Elżanowski Jerzy , Enss Carmen M.
Published: April 2021

Post-catastrophic damage cartography constitutes a serious research gap in the field of urban history. While fire and war damage maps have been made for centuries, qualitative analyses of these documents, especially from a comparative and transnational perspective, have appeared only recently. In response, this article tracks the coeval emergence of urban archaeology, heritage zoning and war damage mapping across Europe. Based on detailed studies of early post-war Munich and Warsaw, it demonstrates that damage mapping was as much about recording loss as it was about reshaping and reimagining Europe's historic city centres.
Relative abundance of pluripotency-associated candidate genes in immature oocytes andin vitro-produced buffalo embryos (Bubalus bubalis)
Authors: Kumar Satish , Chauhan Manmohan Singh
Published: April 2021

The present study was undertaken to analyze the relative abundance (RA) of pluripotency-associated genes (NANOG,OCT4,SOX2, c-MYC, andFOXD3) in different grades of immature oocytes and various stages ofin vitro-produced buffalo embryos using RT-qPCR. Results showed that the RA ofNANOG,OCT4, andFOXD3transcripts was significantly higher (P< 0.05) in A grade oocytes compared with the other grades of oocytes. The RA of the c-MYCtranscript was significantly higher (P< 0.05) in A grade compared with the C and D grades of oocytes, but the values did not differ significantly from the B grade of oocytes. The RA of theSOX2transcript was almost similar in all grades of the oocytes. The expression levels ofNANOG(P> 0.05),OCT4(P> 0.05), c-MYC(P> 0.05) andSOX2(P< 0.05) were higher in the blastocysts compared with the other stages of the embryos. Markedly,FOXD3expression was significantly higher (P< 0.05) in 8–16-cell embryos compared with the 2-cell and 4-cell embryos and blastocyst, but did not differ significantly from the morula stage of the embryos. In the study, the majority of pluripotency-associated genes showed higher expression in A grade immature oocytes. Therefore, it is concluded that the A grade oocytes appeared to be more developmental competent and are suitable candidates for nuclear cloning research in buffalo. In buffalo,NANOG,OCT4,SOX2, and c-MYCare highly expressed in blastocysts compared with the other stages of embryos.
Writing instruments for managing provincial resources during the Roman occupation of northeast Hispania (2nd and 1st c. BCE)
Authors: Vila Oriol Olesti
Published: April 2021

This article analyzes the presence of writing instruments dating to the 2nd–1st c. BCE at several archaeological sites of the northeastern Iberian peninsula (current Catalonia), attempting to assess their historical, social, and economic interest. The evidence of the ancient literary sources, as well as the archaeological contexts in which these objects appeared, allow us to interpret these writing instruments as part of the mechanisms of control and recordkeeping deployed by Rome in this territory during the long and complex process of conquest.
Optimisation of Varian TrueBeam head, thorax and pelvis CBCT based on patient size
Authors: Agnew Christina E. , McCallum Candice , Johnston Gail , Workman Adam , Irvine Denise M.
Published: April 2021

Purpose:

The aim of this study was to optimise patient dose and image quality of Varian TrueBeam cone beam computed tomography (CBCT) pelvis, thorax and head and neck (H&N) images based on patient size.

Methods:

An elliptical phantom of small, medium and large size was designed representative of a local population of pelvis, thorax and H&N patients. The phantom was used to establish the relationship between image noise, CT and CBCT exposure settings. Using this insight, clinical images were optimised in phases and the image quality graded qualitatively by radiographers. At each phase, the time required to match the images was recorded from the record and verify system.

Results:

Average patient diameter was a suitable metric to categorise patient size. Phantom measurements showed the power relationship between noise and CBCT exposure settings of value −0·15, −0·35 and −0·43 for thorax, pelvis and H&N, respectively. These quantitative phantom measurements provided confidence that phased variation of ~±20% in mAs should result in clinically usable images. Qualitative assessment of almost 2000 images reduced the exposure settings in H&N images by −50%, thorax images by up to −66% and pelvis images by up to −80%. These optimised CBCT settings did not affect the time required to match images.

Findings:

Varian TrueBeam CBCT mAs settings have been optimised for dose and image quality based on patient size for three treatment sites: pelvis, thorax and H&N. Quantitative phantom measurements provided insight into the magnitude of change to implement clinically. The final optimised exposure settings were determined from radiographer qualitative image assessment.
Visualising the proximal urethra by MRI voiding scan: results of a prospective clinical trial evaluating a novel approach to radiotherapy simulation for prostate cancer
Authors: Blitzer Grace C. , Yadav Poonam , Ko Huaising C. , Kuczmarska-Haas Aleksandra , Burr Adam M. , Bassetti Michael F. , Steinhoff Daniel J. , Borchert Kailee N. , Meudt Jason J. , Hebel Dustin J. , Bailey Stephanie K. , Morris Zachary S.
Published: April 2021

Background:

Delineating the proximal urethra can be critical for radiotherapy planning but is challenging on computerised tomography (CT) imaging.

Materials and methods:

We trialed a novel non-invasive technique to allow visualisation of the proximal urethra using a rapid sequence magnetic resonance imaging (MRI) protocol to visualise the urinary flow in patients voiding during the simulation scan.

Results:

Of the seven patients enrolled, four were able to void during the MRI scan. For these four patients, direct visualisation of urinary flow through the proximal urethra was achieved. The average volume of the proximal urethra contoured on voiding MRI was significantly higher than the proximal urethra contoured on CT, 4·07 and 1·60 cc, respectively (p = 0·02). The proximal urethra location also differed; the Dice coefficient average was 0·28 (range 0–0·62).

Findings:

In this small, proof-of-concept prospective clinical trial, the volume and location of the proximal urethra differed significantly when contoured on a voiding MRI scan compared to that determined by a conventional CT simulation. The shape of the proximal urethra on voiding MRI may be more anatomically correct compared to the proximal urethra shape determined with a semi-rigid catheter in place.
Native and foreign healthcare workers’ knowledge of appropriate use of antibiotics: a prospective pre-post study in Danish nursing homes
Authors: Rasmussen Ida Scheel , Hansen Matilde Bøgelund , Marloth Tina , Arpi Magnus , Jarløv Jens Otto , Arnold Sif Helene , Mogensen Dorthe , Jensen Jette Nygaard
Published: April 2021

Aim:

The aim was to determine the association between healthcare workers’ (HCWs) country of birth and their knowledge of appropriate use of antibiotics, and whether the association changed after an educational intervention.

Background:

Older residents in nursing homes have been recognized to receive excessively antibiotic treatments. HCWs often represent an important link between the older resident and the general practitioner prescribing the antibiotics, thus their knowledge of appropriate use of antibiotics is important.

Methods:

This study was conducted as a prospective pre-post study. Totally, 312 HCWs from 7 nursing homes in Denmark were included. For statistical analyses, χ2 test and a linear mixed regression model were applied.

Findings:

Native HCWs were more likely to have a higher percentage of correct responses to single statements related to knowledge of appropriate use of antibiotics. Native HCWs had a significantly higher knowledge-of-antibiotic score compared to foreign HCWs (−7.53, P < 0.01). This association remained significant after adjusting for relevant covariates (−5.64, P < 0.01). Native HCWs’ mean change in knowledge-of-antibiotic score after the intervention did not differ from the foreign HCWs’ mean change in knowledge-of-antibiotic score.

Conclusion:

Our findings indicate that HCWs born outside Denmark reveal a lower knowledge-of-antibiotic score than HCWs born in Denmark despite comparable educational backgrounds. All participants increased their knowledge from baseline to follow-up. Our findings also indicate that an educational seminar cannot equalize the difference in knowledge between native and foreign HCWs. Studies with larger sample size and a more detailed measurement of cultural identity should investigate this association further.
Psychological well-being of palliative care professionals: Who cares?
Authors: Moreno-Milan Beatriz , Breitbart Bill , Herreros Benjamin , Olaciregui Dague Karmele , Coca Pereira María Cristina
Published: April 2021

Background

Traditionally, the psychological well-being of healthcare workers has been taken for granted — it has even been considered a part of the requirements that were demanded of them. When these professionals have experienced suffering and psychological depletion, they have been held accountable for this suffering, adopting an individualistic and reductionist viewpoint focused only on the professional. This approach has become obsolete due to its proven ineffectiveness, especially from an ethics of responsibility and organization viewpoint.

Context

The psychological well-being of the healthcare worker (and its opposites: suffering, exhaustion, and disenchantment) is advantageous to the professional's commitment to the institution, to their work performance, and to their personal life.

Objective

The objective of this paper is to reflect on the psychological suffering of the palliative care professional.

Method

We will reflect on the three levels of responsibility that influence such suffering (micro-meso-macro-ethical; worker-environment-institution).

Results

We will propose a global strategy for the care of psychological well-being supported by scientific evidence and key references.

Significance of results

We conclude with some contributions on what we have learned and still have to learn on this topic.
Wearing the Pants(suit)? Gendered Leadership Styles, Partisanship, and Candidate Evaluation in the 2016 U.S. Election
Authors: Bernhard Rachel
Published: April 2021

Do messages that evoke a gendered leadership style affect attitudes toward well-known candidates? If so, among what sorts of voters? I show that voters’ evaluations of national politicians, including Hillary Clinton, can be influenced by presenting candidates as stereotypically masculine or feminine leaders. In two survey experiments of California registered voters (n= 1,800 each) conducted at the height of the 2016 presidential election campaign, I find that, on average, voters seemed to prefer both male and female politicians more when they were described as having feminine leadership styles. However, clear heterogeneous treatment effects occurred: Democrats, liberals, and women from all parties evaluated politicians more favorably when they were described as feminine; Republicans, conservatives, and voters for Donald Trump evaluated the same candidates less favorably when described as feminine. The findings have implications for scholarship that links gender stereotyping, partisanship, and ideology to voter behavior.
Pilot study of a group worry intervention for recent onset psychosis
Authors: Mackintosh Teal , Lean Melanie , Hardy Kate
Published: April 2021

Worry is common among individuals with psychosis and has been found to be a causal factor in the development of paranoia. Previous research has shown that a cognitive behavioural therapy protocol targeting worry helps to reduce persecutory delusions and associated distress in a population experiencing longstanding psychotic symptoms. However, there has yet to be a published adaptation of the protocol for individuals experiencing a recent onset of psychosis. The current study aims to examine the feasibility of adapting the worry intervention for recent onset psychosis in a group setting. Six young adults with a recent onset of psychosis, aged 18–32 years, participated in a pilot study of an 8-week group intervention covering cognitive behavioural strategies for managing worry, including worry periods, worry postponement techniques, mindfulness and relaxation, and problem solving. Pre- and post-intervention data were collected on worry, anxiety, depressive symptoms, psychotic symptoms, and perceived recovery from psychosis. In addition, qualitative feedback from group members was gathered during a post-intervention focus group. Feasibility of the group appeared promising, despite high participant attrition. All components of the intervention were successfully implemented, and group members provided positive feedback regarding acceptability of the group. Contrary to prediction, there was not a consistent decrease in worry from pre- to post-intervention. Findings from secondary symptom measures were mixed and may have been related to participants’ subjective experience of the group. Specifically, participants who experienced high levels of group cohesion seemed to benefit more from the intervention.

Key learning aims

(1)

To gain awareness of the gaps in treatment for early psychosis.

(2)

To understand the role of worry in psychosis.

(3)

To learn about the feasibility of implementing a group worry intervention for recent onset psychosis.

(4)

To consider the impact of group cohesion and symptom severity on treatment engagement.
Neonatal nicotine exposure changes insulin status in fat depots: sex-related differences
Authors: Rodrigues Vanessa da Silva Tavares , Miranda Rosiane A. , Soares Patricia Novaes , Peixoto Thamara Cherem , de Oliveira Elaine , Manhães Alex C. , de Moura Egberto Gaspar , Lisboa Patrícia Cristina
Published: April 2021

Nicotine is the main psychoactive substance present in cigarette smoke that is transferred to the baby by breast milk. In rats, maternal nicotine exposure during breastfeeding induces obesogenesis and hormone dysfunctions in adult male offspring. As glucocorticoid (GC), insulin, and vitamin D change both adipogenesis and lipogenesis processes, we assessed parameters related to metabolism and action of these hormones in visceral and subcutaneous adipose tissues (VAT and SAT) of adult male and female rats in a model of neonatal nicotine exposure. At postnatal (PN) day 2, dams were kept with six pups (three per sex) and divided into nicotine and control groups for implantation of osmotic minipumps that released 6 mg/kg nicotine or saline, respectively. At PN180, fat mass, hormone levels, and protein contents of biomarkers of the GC activation and receptor (11beta-hydroxysteroid dehydrogenase type 1 and glucocorticoid receptor alpha), insulin signaling pathway [insulin receptor beta (IRβ), phosphorylated insulin receptor substrate 1, insulin receptor substrate 1 (IRS1), phosphorylated serine/threonine kinase (pAKT), serine/threonine kinase, glucose transporter type 4 (GLUT4)], and vitamin D activation and receptor (1α-hydroxylase and vitamin D receptor) were evaluated. While nicotine-exposed males showed increased fat mass, hypercorticosteronemia, hyperinsulinemia, and higher 25-hydroxyvitamin D, these alterations were not observed in nicotine-exposed females. Nicotine-exposed males only showed lower IRS1 in VAT, while the females had hyperglycemia, higher pAKT in VAT, while lower IRβ, IRS1, and GLUT4 in SAT. Parameters related to metabolism and action of GC and vitamin D were unaltered in both sexes. We evidence that exposure exclusively to nicotine during breastfeeding affects the hormone status and fat depots of the adult progeny in a sex-dependent manner.
Evidence for the Scarr–Rowe Effect on Genetic Expressivity in the Health and Retirement Study
Authors: Woodley of Menie Michael A. , Peñaherrera-Aguirre Mateo , Dunkel Curtis S. , Sarraf Matthew A.
Published: April 2021

The Scarr–Rowe effect is a gene × environment interaction, which is characterized by a negative association between exposure to low socioeconomic status (SES) environments and the additive heritability of cognitive ability. Utilizing a polygenic score for educational attainment (EA3), it was found that the two-way interaction between EA3 and parental educational attainment (EA; used as a proxy for parental SES) was a significant positive predictor of participants’ composite cognitive ability (IQ) score (β = .018, SE = .008, p = .028) after controlling hierarchically for the direct effects of (population-stratification-controlled) EA3, parental EA, and 20 distinct interaction terms (10 involving the interactions between the principal components [PCs] and EA3, and 10 involving the interaction between the PCs and parental EA). The presence of this interaction is consistent with the Scarr–Rowe effect, as the expressivity of EA3 on cognitive ability increases with increasing parental EA. No statistically significant sex differences in the effect magnitudes were found, although the effect was significantly present in the female but not male sample.
Environmental cues affecting horseweed (Conyza canadensis) growth types and their sensitivity to glyphosate
Authors: Schramski John A. , Sprague Christy L. , Patterson Eric L.
Published: April 2021

Horseweed [Conyza canadensis(L.) Cronquist] is a facultative winter annual weed that can emerge from March to November in Michigan. Fall-emergingC. canadensisoverwinters as a rosette, while spring-emergingC. canadensisskips the rosette stage and immediately grows upright upon emergence. In Michigan, primary emergence recently shifted from fall to spring/summer and therefore from a rosette to an upright growth type. Growth chamber experiments were conducted to determine (1) whether bothC. canadensisgrowth types could originate from a single parent and (2) whether common environmental cues can influence growth type. Variations in temperature, photoperiod, competition, shading, and soil moisture only resulted in the rosette growth type in fourC. canadensispopulations originating from seed collected from a single parent of the upright growth type. However, a vernalization period of 4 wk following water imbibition, but before germination, resulted in the upright growth type. Dose–response experiments were conducted to determine whether glyphosate sensitivity differed betweenC. canadensisgrowth types generated from a single parent of the upright growth type. Upright-typeC. canadensisfrom known glyphosate-resistant populations ISB-18 and MSU-18 were 4- and 3-fold less sensitive to glyphosate than their rosette siblings, respectively. Interestingly, differences in glyphosate sensitivity were not observed between growth types from the susceptible population. These results suggest that whileC. canadensispopulations shift from winter to summer annual life cycles, concurrent increases in glyphosate resistance could occur.
Global Microphysical Sensitivity of Superparameterized Precipitation Extremes
Authors: Charn Alexander B. , Collins William D. , Parishani Hossein , Risser Mark D.
Published: April 2021

A recent study found statistically significant differences in extreme precipitation distributions over the contiguous United States (CONUS) when changing the microphysics scheme in a superparameterized global climate model. Here, we repeat the analysis globally and similarly find that differences are widespread when varying the number of predicted moments in the microphysics parameterization, but not when comparing variants of the double‐moment scheme. However, contrary to the previous study in which differences largely disappeared over CONUS when 5‐day simulations were conducted, we found that the signal in these shorter integrations remains within the tropics, implying a direct local effect of microphysics on precipitation extremes in these regions. The effect on precipitation is traced back to changes in vertical velocity profiles changes that are then amplified in the climatological simulations compared to the 5‐day ones. Finally, the superparameterized extremes, regardless of the microphysics scheme, are shown to be larger than those from the Global Precipitation Climatology Project One‐Degree Daily data set and generally smaller than those from the Tropical Rainfall Measuring Mission 3B42 data set.
Bursty Ion Escape Fluxes at Mars
Authors: Dubinin E. , Fraenz M. , Pätzold M. , Tellmann S. , Woch J. , McFadden J. , Zelenyi L.
Published: April 2021

Based on the Mars Atmosphere and Volatile Evolution measurements we have observed cases when the fluxes of oxygen ions escaping the Martian ionosphere exceed their median values by more than a factor of 100. In the Martian tail very high fluxes of the more energetic (E > 30 eV) oxygen ions fill the plasma sheet which then becomes much broader than under conditions with median values of ion fluxes. We have analyzed the occurrence of such events in the upper ionosphere near the terminator plane, which is the main source region of ions in the plasma tail. The maximum values of fluxes of oxygen ions with E > 30 eV were observed mostly in the hemisphere where the motional electric field imposed by the solar wind is directed outward from the planet. Although high values of the solar wind dynamic pressure and (or) the motional electric field are favorable for the observation of the extreme values of ion fluxes with E > 30 eV, there must also be other factors which initiate these events. In particular, we found a close relation of the maximum ion fluxes with the values of the simultaneously measured fluxes of solar wind penetrating into the upper ionosphere. Direct interaction of both plasmas might be a critical factor for the strong growth of the oxygen ion escape. Very high fluxes of the low‐energy oxygen ions (E < 30 eV) are often related with ion “clouds” with anomalously large number density observed in the upper ionosphere.
Complicated Lithospheric Structure Beneath the Contiguous US Revealed by Teleseismic S‐Reflections
Authors: Liu Tianze , Shearer Peter M.
Published: April 2021

Lithospheric discontinuities, including the lithosphere‐asthenosphere boundary (LAB) and the enigmatic mid‐lithospheric discontinuities (MLDs), hold important clues about the structure and evolution of tectonic plates. However, P‐ and S‐receiver‐function (PRF and SRF) techniques, two traditional techniques to image Earth's deep discontinuities, have some shortcomings in imaging lithosphere discontinuities. Here, we propose a new method using reflections generated by teleseismic S waves (hereafter S‐reflections) to image lithospheric discontinuities, which are less affected by multiple phases than PRFs and have better depth resolution than SRFs. We apply this method to the data collected by the Transportable Array and other regional seismic networks and obtain new high‐resolution images of the lithosphere below the contiguous US. Beneath the tectonically active Western US, we observe a negative polarity reflector (NPR) in the depth range of 60–110 km, with greatly varying amplitude and depth, which correlates with active tectonic processes. We interpret this feature as the LAB below the Western US. Beneath the tectonically stable Central and Eastern US, we observe two NPRs in the depth ranges of 60–100 km and 100–150 km, whose amplitude and depth also vary significantly, and which appear to correlate with past tectonic processes. We interpret these features as MLDs below the Central and Eastern US. Our results show reasonable agreement with results from PRFs, which have similar depth resolution, suggesting the possibility of joint inversion of S‐reflections and PRFs to constrain the properties of lithospheric discontinuities.
Syn‐Orogenic Exhumation of High‐P Units by Upward Extrusion in an Accretionary Wedge: Insights From the Eastern Elba Nappe Stack (Northern Apennines, Italy)
Authors: Ryan E. , Papeschi S. , Viola G. , Musumeci G. , Mazzarini F. , Torgersen E. , Sørensen B. E. , Ganerød M.
Published: April 2021

The E‐vergent Northern Apennines formed by Oligocene‐Miocene convergence and westward subduction of Adria beneath Europe. Extension ensued in the Mid‐Late Miocene reflecting lower plate roll‐back and causing opening of the back‐arc Northern Tyrrhenian Sea. Post‐orogenic extension is commonly advocated as the main driver of the exhumation of the belt's inner domain high‐pressure/low‐temperature (HP‐LT) rock units. The Acquadolce Subunit of the Eastern Elba nappe stack contains HP‐LT rocks recording peak blueschist conditions of 1.5–1.8 GPa at 320°C–370°C loosely dated to the Oligocene‐Early Miocene. It is sandwiched by two Late Miocene, out‐of‐sequence top‐to‐the E thrusts between Jurassic LP serpentinites on top and HT–LP contact metamorphosed marbles at its base. We document widespread W‐verging ductile asymmetries within the Acquadolce Subunit, which correspond to top‐to‐the W extensional shearing for the nappe stack current orientation. This allowed for early syn‐orogenic exhumation from blueschist‐ to greenschist‐facies conditions, wherein coeval W‐directed extension at the top of the exhuming units acted synchronously with E‐directed thrusting at their base causing exhumation by extrusion in an overall contractional setting. The basal, E‐vergent thrusting is, however, challenging to document as the wedge has since been reworked by Late Miocene, E‐verging compressive tectonics, contact metamorphism, and later extension, obliterating much of the evidence supporting exhumation by extrusion during the early stages of wedge build‐up. Syn‐orogenic exhumation by extrusion from deep structural levels within the orogenic wedge is a viable mechanism to account for other exhumed HP‐LT units in the inner part of the belt.
How to turn up the heat on the cold immune microenvironment of metastatic prostate cancer
Authors: Stultz Jacob , Fong Lawrence
Published: April 2021

Background

Advanced prostate cancer remains one of the most common and deadly cancers, despite advances in treatment options. Immunotherapy has provided little benefit to a majority of patients, largely due to the immunosuppressive tumor microenvironment that gives rise to inherently “cold tumors”. In this review, we discuss the immunopathology of the prostate tumor microenvironment, strategies for treating prostate cancer with immunotherapies, and a perspective on potential approaches to enhancing the efficacy of immunotherapies.

Methods

Databases, including PubMed, Google Scholar, and Cochrane, were searched for articles relevant to the immunology of prostate cancer. We discuss the impact of different types of treatments on the immune system, and potential mechanisms through which prostate cancer evades the immune system.

Results

The tumor microenvironment associated with prostate cancer is highly immunosuppressive due to (1) the function of regulatory T cells, tumor-associated macrophages, and myeloid-derived suppressor cells (MDSCs), (2) the cytokine milieu secreted by tumor stromal cells and fibroblasts, and (3) the production of adenosine via prostatic acid phosphatase. Both adenosine and tumor growth factor beta (TGF-beta) serve as potent immunosuppressive molecules that could also represent potential therapeutic targets. While there have been many immunotherapy trials in prostate cancer, the majority of these trials have targeted a single immunosuppressive mechanism resulting in limited clinical efficacy. Future approaches will require the integration of improved patient selection as well as use of combination therapies to address multiple mechanisms of resistance.

Conclusion

Prostate cancer inherently gives rise to multiple immunosuppressive mechanisms that have been difficult to overcome with any one immunotherapeutic approach. Enhancing the clinical activity of immunotherapies will require strategic combinations of multiple therapies to address the emerging mechanisms of tumor immune resistance.
Microbiome assembly for sulfonamide subsistence and the transfer of genetic determinants
Authors: Deng Yu , Huang Yue , Che You , Yang Yu , Yin Xiaole , Yan Aixin , Dai Lei , Liu Yang-Yu , Polz Martin , Zhang Tong
Published: April 2021

Antibiotic subsistence in bacteria represents an alternative resistance machinery, while paradoxically, it is also a cure for environmental resistance. Antibiotic-subsisting bacteria can detoxify antibiotic-polluted environments and prevent the development of antibiotic resistance in environments. However, progress toward efficient in situ engineering of antibiotic-subsisting bacteria is hindered by the lack of mechanistic and predictive understanding of the assembly of the functioning microbiome. By top–down manipulation of wastewater microbiomes using sulfadiazine as the single limiting source, we monitored the ecological selection process that forces the wastewater microbiome to perform efficient sulfadiazine subsistence. We found that the community-level assembly selects for the same three families rising to prominence across different initial pools of microbiomes. We further analyzed the assembly patterns using a linear model. Detailed inspections of the sulfonamide metabolic gene clusters in individual genomes of isolates and assembled metagenomes reveal limited transfer potential beyond the boundaries of the Micrococcaceae lineage. Our results open up new possibilities for engineering specialist bacteria for environmental applications.
Neutrophil to lymphocyte ratio influences impact of steroids on efficacy of immune checkpoint inhibitors in lung cancer brain metastases
Authors: Lauko Adam , Thapa Bicky , Sharma Mayur , Muhsen Baha’eddin , Barnett Addison , Rauf Yasmeen , Borghei-Razavi Hamid , Tatineni Vineeth , Patil Pradnya , Mohammadi Alireza , Chao Samuel , Murphy Erin S. , Angelov Lilyana , Suh John , Barnett Gene H. , Nowacki Amy S. , Pennell Nathan , Ahluwalia Manmeet S.
Published: April 2021

Steroids are often utilized to manage patients with non-small cell lung cancer brain metastases (NSCLCBM). Steroids and elevated neutrophil-to-lymphocyte ratio (NLR) have been associated with decreased overall survival (OS) in patients treated with immune checkpoint inhibitors (ICI). We retrospectively investigated patients treated with ICI after the diagnosis of NSCLCBM at a single tertiary care institution examing the impact of steroids and NLR. Overall survival (OS) and intracranial progression-free survival (PFS) were analyzed. 171 patients treated with ICI for NSCLCBM were included. Thirty-six received steroids within 30 days of the start of ICI, and 53 patients had an NLR ≥ 5 before the start of ICI. Upfront steroids was associated with decreased OS on multivariable analysis (median OS 10.5 vs. 17.9 months, p = .03) and intracranial PFS (5.0 vs. 8.7 months, p = .045). NLR ≥ 5 was indicative of worse OS (10.5 vs. 18.4 months, p = .04) but not intracranial PFS (7.2 vs. 7.7 months, p = .61). When NLR and upfront steroids are modeled together, there is a strong interaction (p = .0008) indicating that the impact of steroids depended on the patient’s NLR. In a subgroup analysis, only in patients with NLR < 4 was there a significant difference in OS with upfront steroids (26.1 vs. 15.6 months, p = .032). The impact of steroids on the efficacy of ICI in patients with NSCLCBM is dependent on the patient's NLR underscoring its importance in these patients. Patients with a low NLR, steroid use decreases the efficacy of ICI. These results can inform clinicians about the impact of steroids in patients treated with ICI.
Clinicopathological characteristics and prognostic factors of cervical adenocarcinoma
Authors: Wang Min , Yuan Bo , Zhou Zhen-huan , Han Wei-wei
Published: April 2021

We aimed to assess the clinicopathological features and to determine the prognostic factors of cervical adenocarcinoma (AC). Relevant data were extracted from surveillance, epidemiology and end results database from 2004 to 2015. The log-rank test and Cox proportional hazard analysis were subsequently utilized to identify independent prognostic factors. A total of 3102 patients were identified. The enrolled patients were characterized by higher proportion of early FIGO stage (stage I: 65.9%; stage II: 14.1%), low pathological grade (grade I/II: 49.1%) and tumor size ≤ 4 cm (46.8%). The 5- and 10-year cancer-specific survival rates of these patients were 74.47% and 70.00%, respectively. Meanwhile, the 5- and 10-year overall survival (OS) rates were 71.52% and 65.17%, respectively. Multivariate analysis revealed that married status, surgery as well as chemotherapy were independent favorable prognostic indicators. Additionally, aged > 45, tumor grade III/IV, tumor size > 4 cm, advanced FIGO stage and pelvic lymph node metastasis (LNM) were unfavorable prognostic factors (all P < 0.01). Stratified analysis found that patients without surgery could significantly benefit from chemotherapy and radiotherapy. In addition, chemotherapy could significantly improve the survival in stage II–IV patients and radiotherapy could only improve the survival in stage III patients (all P < 0.01). Marital status, age, grade, tumor size, FIGO stage, surgery, pelvic LNM and chemotherapy were significantly associated with the prognosis of cervical AC.
Noble-metal-free hydroxyapatite activated by facile mechanochemical treatment towards highly-efficient catalytic oxidation of volatile organic compound
Authors: Xin Yunzi , Shirai Takashi
Published: April 2021

Controlling of volatile organic compound (VOC) emitted from industrial processes as most abundant and harmful air pollutant, has become one of the most important global environmental issues due to the rapid urbanization and industrialization. As an alternative and new type catalyst instead of conventional noble-metal nanoparticles widely utilized in oxidative decomposition of VOC, here we report the superior catalytic performance with 100% CO2/CO conversion on hydroxyapatite (HAp, Ca10(PO4)6(OH)2) with structurally well-controlled active surface tailored via facile one-step mechanochemical treatment in ambient air. With detailed characterizations of particle morphology, crystallinity and chemical structure with respects to surface defect/oxygen vacancy formation, acidity/basicity and VOC affinity on HAps activated through different mechanical stresses when altered ball size is utilized in planetary ball-milling assisted mechanochemical process, it was found that the predominant defect/oxygen vacancy generation in PO43− site and enhanced basic site population established by selective mechanochemical activation of c-plane, facilitates the favorable catalytic oxidation route towards highly-efficient CO2/CO conversion of VOC. Regards to the cost-effectiveness and non-toxic nature of HAp, incorporated with the sustainable mechanochemical surface structure tuning process, the results presented in this work opens new strategy in development of novel noble-metal-free catalyst for VOC elimination and environmental cleaning techniques.