bluuebunny/crossref_metadata_2025 huggingface dataset:
Aplicando o conhecimento sociocultural da produção artesanal de queijo de coalho nas aulas de química em uma turma da educação básica
Authors: Gomes Jacqueline Pereira , Dantas Filho Francisco Ferreira
Published: July 2024

O queijo possui relevante valor proteico, além de ter composição à base de lipídios, carboidratos, sais minerais, cálcio, fósforo e vitaminas, entre elas A e B; sendo assim, este produto torna-se uma boa ferramenta para oportunizar o debate nas aula de Química. Nesse sentido, este trabalho tem como objetivo vincular a disciplina de Química à temática sociocultural Produção de queijo de coalho, produto fabricado por uma família de agricultores e estudantes campesinos residentes na zona rural Floriano do município de Soledade, estado da Paraíba, Brasil. Os sujeitos envolvidos foram 30 alunos matriculados na 2ª Série do Ensino Médio de uma escola pública integral que oferta o curso Técnico em Agropecuária e uma família de produtores de queijo. Este trabalho é marcado pela aplicação de uma intervenção de ensino que engloba entrevistas, histórias, vivências, experiências, dinâmicas e diálogos entre a disciplina de Química e a produção artesanal de queijo de coalho. A partir dos resultados, foi possível concluir que o uso de temáticas socioculturais nas aulas de Química proporciona aos educandos um aprendizado dinâmico e significativo.
A PRELIMINARY SURVEY ON DIVERSITY OF AVIFAUNA IN KATWA, PURBA BURDWAN, WEST BENGAL, INDIA
Authors:   Department of Zoology, Katwa College, Katwa, Purba Burdwan, West Bengal., Dutta Shampa
Published: July 2024

Birds are used as bio-indicator due to their sensitivity to minor environmental changes. A survey was done from July 2022 to February 2023 to study the avifaunal diversity of Katwa. A total of 67 bird species were recorded during the study period. The species were categorized in three namely common resident (CR), not common resident (NCR) and migratory (M) of which 40 are common resident, 24 are not common resident and 3 are migratory. The found common birds species were house crow, common myna, red vented bulbul, house sparrow, spotted dove, asian koel, little ringed plover etc. Among the not common resident avifauna were Long-legged Buzzard, Cotton teal, Pied-cuckoo, Grey Wagtail, yellow Wagtail, White Wagtail etc. and the three migratory birds were Common Pochard, Red-crested Pochard and Northern Pintail. Katwa and adjoining Ajay Baadh has wide variety of trees, wetland, grassland and agricultural land which is the major contributing factor for the rich avifaunal diversity found during the short study period. This is a preliminary effort for documentation of the avifauna, but more studies and suitable conservation strategies are required in the study area.
PRIMARY CUTANEOUS ASPERGILLOSIS IN A 13-YEAR-OLD BOY WITH BONE MARROW APLASIA: CASE REPORT
Authors:   Department of Pediatrics, Mohammed VI University Hospital, Oujda, Morocco., Lhamel Raounak , Ghanam Ayad ,   Department of Pediatrics, Mohammed VI University Hospital, Oujda, Morocco., Babakhouya Abdeladim ,   Department of Pediatrics, Mohammed VI University Hospital, Oujda, Morocco., Rkain Maria ,   Department of Pediatrics, Mohammed VI University Hospital, Oujda, Morocco., Benajiba Noufissa ,   Department of Pediatrics, Mohammed VI University Hospital, Oujda, Morocco.
Published: July 2024

Cutaneous aspergillosisis a rare condition, and while rare in immunocompetent individuals, it predominantly affects immunosuppressed patients, particularly those with hematological-oncological disorders within the pediatric demographic. Herein, we present a 13-year-old boy under follow-up for bone marrow aplasia. The child developed long-lasting fever and papulous and ulcerous indurated skin lesions on his whole body. Blood count showed agranulocytosis with neutrophils count of 10/Î¼l. Thoracic, abdominal and pelvic Computed Tomography (CT) scan has revealed bilateral alveolar syndrome in the lungs. Skin biopsy revealed cutaneous aspergillosis. Despite treatment, the boys condition did not improve, and he passed away 2 weeks following his hospital admission because of septic shock. Cutaneous aspergillosis is due to Aspergillus flavus and A. fumigatus, for primary and secondary (invasive) cases, respectively. The rapid progression of this disease from the initial cutaneous infectious region necessitates prompt medical intervention to avoid increasing the risk of mortality. This condition typically manifests after the fungus is directly inoculated through skin contact with contiguous infected areas or via hematogenous spread from a remote mycotic site to the skin.
Optimizing SMEs Through Digital Design for Sustainable Industrial Development
Authors: Limano Ferric
Published: July 2024

SMEs (Small and Medium Enterprises) are the pillars of Indonesia's economy, as evidenced by their significant contribution to the country's gross domestic product. The digital disruption era, particularly during the pandemic, has necessitated changes in product development and marketing strategies for SMEs, pushing them towards digital approaches. This research aims to study the application of digital design in branding and digital marketing strategies by SMEs, providing recommendations based on the ADDIE model (Analysis, Design, Development, Implementation, Evaluation). The qualitative research method utilized data from two product samples: Maicih (Food) and Compass (Fashion). In the case of Maicih, engagement was built through a viral snack brand known for its unique spicy flavors, enjoyed socially. The brand's social media, featuring the tagline "cerita emak" (mother's stories), helped foster interaction and drive traffic to online marketplaces. For Compass, the focus was on building a sneaker community, facilitating buying and selling within the community, and fostering emotional connections through collaborations. This study encompasses market analysis, brand design, and the digital development and implementation process. SMEs that can adapt and sustain themselves can address the sustainability goal: "Build resilient infrastructure, promote inclusive and sustainable industrialization, and foster innovation.”
GEÇ OSMANLI-ERKEN CUMHURİYET DÖNEMİ’NDE TÜRKİYE’DE FUTBOL VE SİYASET İLİŞKİSİ
Authors: Say Hüseyin
Published: July 2024

Türkiye’de futbol, bu topraklarda oynanmaya başladığından beri siyaset ile iç içedir. Saraya yakınlığı nedeniyle ayrıcalıklı bir konumda olan Galatasaray Lisesi öğrencileri hariç, Türk ve Müslüman tebaanın 1908’e kadar futbol oynaması ve futbol takımı kurması yasaktır. İttihat ve Terakki Cemiyeti’nin iktidarı ele geçirmesiyle futbol, Cemiyet’in politikasına paralel olarak milliyetçi bir karakter göstermiştir. Bu dönemde takımlar, Cemiyet’le bir şekilde ilişki kurmuş ve belli avantajlardan yararlanmak istemişlerdir. Aynı zamanda Cemiyet de futbolun kitleleri etkileme gücünü kullanabilmek adına futbola yönelmiştir. Futbolun siyasetle olan ilişkisi değişen tüm koşullara rağmen Birinci Dünya Savaşı Dönemi’nde, Kurtuluş Savaşı Dönemi’nde ve Tek Parti Türkiye Cumhuriyeti Dönemi’nde de sürmüştür. Takımlar, değişen koşullara hızlıca adapte olmuş ve siyasete yakın durarak belli imtiyazlara sahip olmayı tercih etmişlerdir. Bu çalışmada futbolun Osmanlı İmparatorluğu’na girişinden, tek partili Türkiye Cumhuriyeti Dönemi’ne kadar olan serüveni, siyasete yakınlık bağlamında incelenmiştir.
Combined Ultrasound and Microwave Food Processing: Efficiency Review
Authors: Burak Leonid , Zavaley Andrey
Published: July 2024

Modern methods of food processing combine ultrasonic and microwave treatment. This article reviews scientific publications on combined microwave and ultrasound technologies in food processing.
The review involved standard methods of data analysis and covered 85 Scopus and Web of Science research papers on combined microwave and ultrasonic food treatment published in English in 2010–2023.
The article describes the principles and specific features of ultrasonic and microwave food processing methods, their combinations, equipment design, and applications as part of various food processing stages, e.g., defrosting, drying, extraction, sterilization, etc. Microwaves increase the heating rate while ultrasound increases the efficiency of heat and mass transfer. Their combined use reduces processing time, improves product quality, facilitates moisture drainage, and provides uniform heating. The combined effect of microwaves and ultrasound increases the processing efficiency, thus preserving the nutritional value and quality of the final product. Ultrasonic technology serves as an aid to efficient and environmentally-friendly microwave heating, which has a wide range of applications in the food industry.
The review can be used in further research in extraction, drying, defrosting, and sterilization. It can help food industry specialists to select optimal food processing methods.
Bioactive Anti-Aging Substances: Geroprotectors
Authors: Fokina Anna , Vesnina Anna , Frolova Anna , Chekushkina Darya , Proskuryakova Larisa , Aksenova Larisa
Published: July 2024

People are constantly exposed to adverse environmental factors that affect their health. If combined with hereditary predisposition, they may lead to gerontological changes that reduce healthy and working life expectancy. Some measures can prevent premature aging, e.g., a balanced diet or biologically active anti-aging substances also called geroprotectors. This article reviews biologically active geroprotectors with a view to select promising components for novel biologically active additives and functional foods.
The review covered five years of Russian research articles and patents on biologically active anti-aging agents indexed in the National Center for Biotechnology Information, ScienceDirect, eLIBRARY.RU, and the database of the Federal Institute of Industrial Property.
The domestic market demonstrates a growing demand for biologically active supplements: in 2023, it increased by 10% in value terms as consumers’ interest in a healthy and long life continues to grow. The review also included quality criteria for biologically active anti-ageing agents, e.g., such plant metabolites as vitamins, polyphenols, antioxidants, adaptogens, peptides, etc. Thymalin, epithalamin, dasatinib, and epithalon are available on the domestic market.
The list of potential anti-aging agents includes ethylamine, carnosine, glutathione, ubiquinone, curcumin, rutin, quercetin, resveratrol, senolytics, and sirutins. These biologically active substances prevent oxidative stress, accumulation of lipofuscin, and senescent cells. The most effective anti-aging agents come from Vitis amurensis, Rhodiola rosea, Schisandra chinensis, Galega officinalis, Eleutherococcus senticosus, Withania somnifera, and Panax ginseng.
As súplicas de Hércules no prólogo da tragédia senequiana Hercules Oetaeus: um apelo pela imortalidade
Authors: Moraes de Caldas Viviane
Published: July 2024

Hercules Oetaeus (Hércules no Eta) é uma das tragédias de Sêneca, cujo tema principal é a morte e a apoteose do grande herói Hércules. O prólogo da tragédia senequiana é composto por 103 versos, através dos quais Hércules, falando em primeira pessoa, tenta persuadir Zeus, seu pai e senhor dos deuses, a conceder-lhe a imortalidade. Nosso artigo tem como objetivo apresentar as súplicas do herói no prólogo da tragédia Hercules Oetaeus, juntamente com a tradução e comentários dos versos em que o herói elenca os feitos gloriosos realizados por ele. Entendemos que a figura de Hércules serve de exemplo, através do qual os princípios da doutrina estoico-senequiana podem ser demonstrados e, sobretudo, difundidos. Utilizaremos como texto-base a edição estabelecida por Fitch (2004); e, para nos auxiliar na simbologia dos mitos, lançaremos mão dos estudos de Brandão (2010; 2012); e a obra filosófica de Sêneca nos servirá de guia para nossas considerações.
APRENDIZAGEM HISTÓRICA NA INFÂNCIA:
Authors: Araújo de Alvarenga Thábata
Published: July 2024

Este artigo tem por objetivo compreender a aprendizagem histórica na infância, no espaço escolar do Núcleo de Educação Infantil (NEI-CAp-UFRN), escola de aplicação vinculada ao então Departamento de Educação da Universidade Federal do Rio Grande do Norte, entre os anos de 1988 e 2006. Nesse trabalho, para analisarmos as narrativas produzidas pelas crianças que estavam em processo de alfabetização e frequentavam o último ano da educação infantil (Turma 5) no NEI, utilizamo-nos das categorias de imaginação histórica e aprendizagem histórica, a partir dos postulados teóricos produzidos, sobretudo, por Hayden White e Jörn Rüsen. A análise qualitativa das narrativas, demonstra como a cultura escolar e os saberes históricos produzidos no NEI, influenciavam o pensamento das crianças que lá estudavam.
REASSENTAMENTOS EM MOÇAMBIQUE:
Authors: Valia Isidoro Jacob , Matos Elmer Agostinho Carlos de
Published: July 2024

Com base numa revisão de literatura, o artigo aborda as principais ideias de autores que discutem o conceitos de território e identidade. Partimos do princípio que qualquer processo de territorialização implica, ao mesmo tempo, um processo de produção de identidades. As variáveis de conceituação do território, tais como funcionalidade, apropriação, simbolismo e relações de poder são analisadas de modo a mostrar como se cruzam  com o conceito de identidade. Numa última fase, buscam-se exemplos práticos do processo de reassetamento para ilustrar como decorre o processo de desterritorialização e (re)territorrialização e, consequentemente, como são produzidas novas identidades.
De Archytas a Franck
Authors: Oliveira Leonardo
Published: July 2024

Este artigo teve como objetivo realizar uma revisão bibliográfica de algumas obras referenciais que tratam do tema da espacialidade na arquitetura. Dessas obras foram extraídas as principais contribuições em relação a esse tema, que foram traduzidas de fontes primárias de modo original e inédito, em alguns casos, e costuradas cronologicamente. A literatura aponta que no século XIX, o conceito de espaço foi introduzido na teoria da arquitetura e desenvolvido a partir de uma abordagem que enfatizava o papel do corpo humano e a sua predisposição cinestésica aos processos de percepção e cognição. Mais recentemente, a questão da percepção espacial, fundamentada em sensações decorrentes do envolvimento direto do indivíduo com o espaço, tem sido desenvolvida a partir de uma abordagem fenomenológica, que busca descrever os fenômenos como são manifestados na experiência aos sentidos humanos. Concluiu-se que essa abordagem, apesar de evidente no pensamento arquitetônico contemporâneo, carece de mais estudos empíricos a fim de contribuir para a formulação do que poderia ser chamado de teoria da arquitetura de inspiração fenomenológica.
Disclosure de informações e governança corporativa: evidências de empresas listadas no IBrX-100
Authors: Amurim Aldir Dias de , Lima Adilson Celestino de
Published: July 2024

Objetivo: Analisar a relação entre a governança corporativa e o nível de disclosure de informações das empresas listadas no IBrX-100.
Metodologia: Estudo descritivo, exploratório e quantitativo, em que o procedimento de coleta de dados de 2016 a 2020 que é o período estudado, caracteriza-se como documental, fazendo uso da técnica de análise de conteúdo e do software Economática®, websites da [B]³ e da Comissão de Valores Mobiliários. A amostra final é composta por 61 empresas. Para análise dos dados utilizou-se o coeficiente de correlação de postos de Spearman e da regressão com dados em painel, ambas realizadas por meio do software RStudio.
Resultados: As evidências mostram que o Índice de Disclosure de Informações (IDI) sofreu poucas oscilações ao longo do período analisado, tendo alcançado um valor médio total de 0,7754, com a maior e a menor média de 0,7787 e 0,7691, respectivamente. Quanto a relação do IDI com as variáveis de governança corporativa, os achados apontaram que não há relação positiva significativa entre o tamanho do conselho, independência do conselho, dualidade de funções do CEO e investidores institucionais com o IDI, mas existe uma relação positiva significativa entre a diversidade de gênero do conselho com o IDI. Estes resultados são consistentes com estudos já realizados no âmbito internacional.
Contribuições do Estudo: A presente pesquisa contribui para a literatura atual ao proporcionar achados empíricos sobre a relação da estrutura de governança corporativa na prática de divulgação de informações por empresas de capital aberto no Brasil, sendo úteis nas tomadas de decisões dos stakeholders e na definição de membros para compor o conselho de administração da empresa. Além disso, este estudo acrescenta a descoberta empírica sobre a relação positiva encontrada entre mulheres diretoras e o disclosure de informações.
Desempenho dos municípios brasileiros nas dimensões do ranking da qualidade da informação contábil e fiscal e a percepção dos profissionais contábeis sobre o tema
Authors: Lima Diana Vaz de , Reis Celina Costa Lima dos , Fialho Gustavo Ferreira , Neves Rodrigo Pereira
Published: July 2024

Objetivo: Analisar o desempenho dos municípios brasileiros nas dimensões do Ranking da Qualidade da Informação Contábil e Fiscal no Siconfi (Ranking) e avaliar a percepção dos profissionais contábeis sobre o tema.
 Metodologia: Para analisar o desempenho dos municípios nas dimensões do Ranking, foi efetuada coleta de dados no sítio da Secretaria do Tesouro Nacional (https://www.tesourotransparente.gov.br/visualizacao/Ranking-da-qualidade-da-informacao-contabil-e-fiscal-estadual) relativos aos exercícios de 2020 a 2023. Para avaliar a percepção dos profissionais contábeis municipais sobre o tema, foi aplicado questionário estruturado com quatro perguntas, elaboradas com o objetivo de capturar a percepção desses profissionais sobre a existência do Ranking, o conhecimento deles quanto aos dados relativos aos municípios em que trabalhavam e eventuais medidas tomadas pelo município para melhorar a nota atribuída pela STN.  Os Municípios foram contatados pela equipe de Call Center da Confederação Nacional de Municípios, devidamente instruída pela equipe de pesquisa.
Resultados: A pesquisa mostra que a Dimensão IV (que compara a Declaração de Contas Anuais, Matriz de Saldos Contábeis e relatórios da Lei de Responsabilidade Fiscal) apresentou o menor percentual de acertos no triênio, revelando problemas na consistência dos dados quando as informações entre relatórios diferentes são comparadas. Com a realização do questionário foi colhido como achado que 40% dos respondentes desconheciam o Ranking e mesmo entre os que não o conhecia 46% não realizaram ações para melhorar a colocação do município no Ranking, revelando o desinteresse dos profissionais ou dos gestores municipais sobre a sua importância no contexto de indicadores da qualidade da informação contábil.
Contribuições do Estudo: Este artigo indica a necessidade de ampliar as pesquisas empíricas sobre a qualidade dos dados contábeis municipais, buscando aperfeiçoar as questões apresentadas no questionário realizado, incluindo, por exemplo, itens que avaliam a melhoria no sistema contábil.
Transparência passiva nos pequenos municípios brasileiros
Authors: Oliveira Anderson Carvalho de , Santos Nálbia de Araújo
Published: July 2024

Objetivo: Este trabalho visa analisar os fatores que influenciam a transparência passiva nos municípios com menos de 50.000 habitantes.
Metodologia: Para atingir o objetivo do estudo, primeiramente, com base nos resultados da técnica de formação de clusters, os municípios foram aglutinados em 03 grupos, conforme o desempenho obtido nas variáveis determinantes da transparência. Em um segundo momento, esses clusters foram avaliados e comparados quanto ao resultado da Escala Brasil Transparente - EBT.
Resultados: Averiguou-se que desenvolvimento econômico e social e a capacidade fiscal do município são variáveis que influenciaram nos resultados da EBT em suas duas edições. Assim, conclui-se que deve ser adotada uma política diferenciada para a promoção da transparência nos pequenos municípios, considerando o respectivo desenvolvimento econômico, fiscal e social. Por fim, observou-se que a atuação dos órgãos de controle e o debate e desenvolvimento de métricas capazes de mensurar a transparência são caminhos possíveis para melhoria dos índices de transparência passiva nos municípios.
Contribuições do Estudo: Os resultados do estudo podem apoiar os gestores de pequenos municípios na promoção de melhorias na transparência passiva de seus municípios. Além disso, podem apoiar os gestores dos municípios na identificação dos fatores que influenciam na sua transparência passiva.
Service to demands and corruption tolerance: brazilian voters' perception of “rouba, mas faz” policy
Authors: Costa Neto João Antonio da , Dantas Júnio Amarando Francisco r , Sousa Rossana Guerra de , Vasconcelos Adriana Fernandes de
Published: July 2024

Purpose: The research aimed to verify the influence of meeting public demands on the perception of tolerance of Brazilian voters towards the “rouba, mas faz” policy. Although a social unison of rejection of corruption in politics is perceived, there is a possibility that voters relax this disapproval in the face of the results that managers offer to communities.
Methodology: Study of quantitative approach, as for the procedures, a survey was used, with a questionnaire and study of scenarios, of tolerance to “rouba, mas faz”, as a research instrument. To analyze the data, descriptive statistics and presentation in percentages were used for the answers to assertions and scenarios.
Results: The results indicate that Brazilians demand honest politicians, although for almost 25% of the population every politician is corrupt, without distinction; for 80% of respondents the main cause of problems in Brazilian public management is political corruption; approximately 70% of voters do not use transparency portals to decide their vote, although 80% claim to research the candidates' history before making their decision.
Contributions of the Study: Aspects related to the median voter theory were perceived, since, although Brazilian voters demonstrate intolerance to corruption, the profile with the average characteristics of the population tends to vote for that candidate who promises to meet their needs. In addition, in general terms, 7% of the sample would re-elect a very corrupt politician, as long as he is very productive, while 24% would tolerate corruption, as long as it occurs on a small scale and is accompanied by works and benefits to society, implying that there is, in general terms, to a certain degree, the influence of meeting public demands on voters' tolerance of the “rouba, mas faz” policy in Brazil.
Potencial do Granito Valsungana: Fonte de K e Sustentabilidade na Agricultura
Authors: Avila Edson Luiz , Corrêa Albertina Xavier da Rosa
Published: July 2024

O Brasil, um dos maiores produtores de alimentos, importa cerca de 93% do cloreto de potássio usado na agricultura. Este estudo explora as rochas silicáticas, especificamente o Granito Valsungana (GV), proveniente de Major Gercino, Nova Trento e Brusque, SC., como fonte alternativa de potássio. O objetivo principal foi avaliar a solubilidade do potássio através de rotas tecnológicas, incluindo cominuição e calcinação a 710°C, com e sem adição de CaCl2.H2O. As amostras foram tratadas com soluções aquosas (pH 5,7 e 7,3), ácidos: cítrico, nítrico e oxálico e melich-1. A solubilidade do potássio ocorreu em todas as amostras, sendo a mais efetiva, calcinada com adição do sal, sob a solução do ácido oxálico, seguido do ácido cítrico, melich-1, e soluções aquosas com pH 5,7 e 7,3. A concentração de potássio foi determinada por absorção atômica. A caracterização do granito “in natura” e do calcinado sem e com adição de fundente (CaCl2·2H2O), foram realizadas por difração e fluorescência de raio-X, microscopia eletrônica de varredura e espectroscopia de infravermelho. Os resultados indicaram troca iônica e reações químicas, demonstrando o potencial do GV como fonte de fertilizante de potássio e sugerindo a necessidade de estudos adicionais sobre a disponibilidade de K no solo.
Palavras-chave: Potássio; Agricultura sustentável; Granito Valsungana.
Análise numérica e estudo de tensão e deformação em comparação com leituras em caixas suecas instrumentadas em uma barragem de enrocamento com face de concreto localizada no Peru
Authors: Barreto Marcelo de Paula , Teixeira Sidnei Helder Cardoso , Acevedo Andres Miguel Gonzalez , Calcina Alex Martins , Tha Pedro de Carvalho , Dutra Paola , Andrade Heber Augusto Cotarelli de , Lopes Julio Cesar , Katereniuk Soraia Bastos
Published: July 2024

No campo da engenharia, as Barragens de Enrocamento com Face de Concreto (BEFC) têm se destacado como uma solução cada vez reconhecida, impulsionada por estudos e histórico de casos reais. A implementação bem-sucedida desse tipo de barragem se baseia em projetos empíricos, apoiados por dados de obras anteriores e acompanhamento de seu desempenho por meio de monitoramento. Um ponto de atenção é a presença de fissuras e trincas na laje de concreto que cobre o talude de montante, causadas pela movimentação e deformações do maciço da barragem. Além disso, a geometria do vale entre as ombreiras também desempenha um papel importante, impactando a redistribuição das cargas e gerando deformações no maciço. Este estudo tem como objetivo principal comparar, por meio de ferramentas computacionais e dados de campo, o comportamento de um material diferente aplicado na barragem.
SLC16A3 is a Prognostic Marker and Affects Immune Regulation in Bladder Cancer
Authors: Li Chengjun , Chu Guangdi , Ma Guofeng , Chen Xinlei , Ma Xiaocheng , Niu Haitao
Published: July 2024

Background:

Overexpression of SLC16A3 can contribute to the development of various
tumors by regulating metabolism, but a systematic analysis of SLC16A3 in bladder cancer
(BC) has been rarely reported.

Methods:

We used the BC datasets from public databases to investigate SLC16A3 expression in
BC. We first analysed the relationship between SLC16A3 expression and clinical characteristics
of 412 bladder cancer patients. After that, gene function analyses and immunocorrelation analyses
of SLC16A3 were conducted with the R package. For immunotherapy effect and drug sensitivity
analysis, we also used the R package. We also analysed the relation between SLC16A3
expression and 20 m6A modification key genes. Finally, we determined the expression localization
of SLC16A3 in bladder cancer by single-cell sequencing analysis using 3,115 BC cells. We
further detected the expression of SLC16A3/MCT4 on BC samples by reversed transcriptionquantitative
polymerase chain reaction and immunohistochemistry.

Results:

The SLC16A3 was overexpressed in BC cells, including epithelial cells (p＜0.001).
The high SLC16A3 expression level of patients with BC was significantly related to poor prognosis
(p＝0.044), and we established a reliable prognosis model for BC patients. Statistically
significant associations between SLC16A3 and m6A modification (ALKBH5) gene (p＜0.001),
key genes in aerobic glycolysis, M2 macrophage infiltration (p＝0.0058), and immune checkpoint
regulation were observed.

Conclusion:

Overexpression of SLC16A3 is an independent prognostic factor in patients with
BC. SLC16A3 may influence the immune infiltration of BC by regulating BC metabolism and
m6A methylation, which ultimately can lead to the progress of BC. For the detection and therapy
of BC, SLC16A3 may be a potent therapeutic target for BC.
Molecular Mechanisms Underlying the Therapeutic Potential of Plant-Based α-Amylase Inhibitors for Hyperglycemic Control in Diabetes
Authors: Kaur Amritpal , Singh Shareen , Mujwar Somdutt , Singh Thakur Gurjeet
Published: July 2024

Background:

Diabetes mellitus (DM), arising from pancreatic β-cell dysfunction and
disrupted alpha-amylase secretion, manifests as hyperglycemia. Synthetic inhibitors of alphaamylase
like acarbose manage glucose but pose adverse effects, prompting interest in plantderived
alternatives rich in antioxidants and anti-inflammatory properties.

Objective:

The current review investigates plant-based alpha-amylase inhibitors, exploring their
potential therapeutic roles in managing DM. Focusing on their ability to modulate postprandial
hyperglycemia by regulating alpha-amylase secretion, it assesses their efficacy, health benefits,
and implications for diabetes treatment

Methods:

This review examines plant-derived alpha-amylase inhibitors as prospective diabetic
mellitus treatments using PubMed, Google Scholar, and Scopus data

Results:

Plant-derived inhibitors, including A. deliciosa, B. egyptiaca, and N. nucifera, exhibit
anti-inflammatory and antioxidant properties, effectively reducing alpha-amylase levels in diabetic
conditions. Such alpha-amylase inhibitors showed promising alternative treatment in managing
diabetes with reduced adverse effects.

Conclusion:

The current literature concludes that plant-derived alpha-amylase inhibitors present
viable therapeutic avenues for diabetes management by modulating alpha-amylase secretion by
regulating inflammatory, oxidative stress, and apoptotic mechanisms involved in the pathogenesis
of diabetes. Further investigation into their formulations and clinical efficacy may reveal their
more comprehensive diabetes therapeutic significance, emphasizing their potential impact on
glucose regulation and overall health.
Screening Analysis of Predictive Markers for Cytokine Release Syndrome Risk in CAR-T Cell Therapy
Authors: Xu Jiayu , Zhao Chengkui , Wei Zhenyu , Xie Weixin , Cheng Qi , Zhang Min , Han Shuangze , Kang Liqing , Xu Nan , Yu Lei , Feng Weixing
Published: July 2024

Background:

Chimeric Antigen Receptor (CAR)-T cell therapy has emerged as a highly
effective treatment for hematological tumors. However, the associated adverse reaction, Cytokine
Release Syndrome (CRS), poses a significant challenge. While numerous studies have investigated
CRS biomarkers during CAR-T cell therapy, the ability to predict CRS risk prior to treatment initiation
remains a crucial yet underexplored aspect.

Objective:

The primary purpose of this study was to address the issue of limited data, explore an alternative
approach using public data to identify predictive markers for CRS risk assessment from
RNA-Seq in pre-treatment patients data, and comprehend the inducible mechanisms underlying
CRS.

Methods:

We integrated information from two public databases, the FDA Adverse Event Reporting
System (FAERS) for adverse reaction reports of CAR-T cell therapy and the Cancer Genome Atlas
(TCGA) for RNA-Seq data on corresponding hematological tumors. Candidate genes were screened
by correlation analysis between Reported Odds Ratio (ROR) values and RNA-Seq gene expression
levels, and then core factors were identified through stepwise analysis of pathway enrichment, cluster
analysis, and protein interactions.

Results:

Our analysis highlighted the correlation between CRS risk and pre-treatment T cell activation/
proliferation, identifying key genes (IFN-γ, IL1β, IL2, IL6, and IL10) as significant CRS indicators.

Conclusion:

This study offers a unique perspective on predicting CRS risk before CAR-T cell therapy,
circumventing the challenges of scarce clinical data by leveraging analysis of public databases.
It elucidates the crucial role of T cell activation/proliferation dynamics in CRS. The analytical
methods and identified markers provide a reference for the research and clinical application of
CAR-T cell therapy.
Sustainable Synthesis of Guanidine Derivatives and Computational Assessment of their Antidiabetic Efficacy
Authors: Ao Imkongyanger , Richa Kikoleho , Lotha Tsenbeni N. , Ao Ketiyala , Rudithongru Lemzila , Nakro Vevosa , Ritse Vimha , Namsa Nima D. , Pankaj Pranay Punj , Sinha Upasana Bora , Jamir Latonglila
Published: July 2024

Background:

Type 2 Diabetes Mellitus (T2DM) represents a significant and pressing
worldwide health concern, necessitating the quest for enhanced antidiabetic pharmaceuticals.
Guanidine derivatives, notably metformin and buformin, have emerged as pivotal therapeutic
agents for T2DM management.

Aims:

The present study introduces an efficient one-pot synthesis method for the production of
symmetrical guanidine compounds and subsequently, their evaluation as potential T2DM agents.

Methods:

This synthesis involves the reaction of isothiocyanates with secondary amines, employing
an environmentally friendly and recyclable reagent, tetrabutylphosphonium tribromide
(TBPTB). In order to understand the mechanics of ligand-protein interaction, ADME/Toxicity,
and drug-likeliness aspects, in silico studies were incorporated.

Results:

An efficient and easy method for synthesis of guanidine compounds has been devised.
Comprehensive assessment of the biological activity of the synthesized guanidine compounds,
specifically in the context of T2DM, has been rigorously conducted.

Conclusion:

Computational analyses have unveiled their substantial potential as promising antidiabetic
agents. Results highlight the relevance of these compounds in the ongoing pursuit of
novel therapeutic solutions for T2DM.
Research Progress in the Relationship between Intestinal Flora and Diabetes Mellitus
Authors: Lai Yingji , Huang Xianfeng , Sun Hongwei , Hui Qi , Hu Shanshan
Published: July 2024

Diabetes mellitus is a common chronic metabolic disease characterized by a high
incidence and disability rate. Intestinal flora refers to the microbial community that lives in the
intestines and plays a crucial role in maintaining intestinal health and the human immune system.
In recent years, an increasing body of research has revealed a close relationship between
intestinal flora and diabetes. The pathophysiological mechanisms between them have also been
constantly uncovered, and the regulation of intestinal flora has shown promising efficacy in the
adjuvant treatment of diabetes. This study mainly summarized the characteristics and mechanisms
of intestinal flora in patients with diabetes in recent years, as well as the methods of regulating
intestinal flora to prevent and treat diabetes, and prospected the future research direction.
This will offer a theoretical basis for the clinical adjuvant treatment of diabetes with intestinal
flora and the development of new drugs.
Correlation Between the Amount of Total Phenolic Contents and Antioxidant Activity of Mediterranean Shrubs: Are Phenols a Good Indicator of the Antioxidant Activity of these Species?
Authors: Chaves Natividad , Navarro Mercedes , Flores Mario , Alias Juan Carlos
Published: July 2024

Background:

Cells generate reactive oxygen species (ROS), which cause oxidative stress.
Such stress is counteracted by a complex antioxidant system, which includes molecules of the secondary
metabolism of plants, mainly phenols. Several studies attribute the antioxidant activity of a
species to these compounds, although, in other studies, this relationship is not clear.

Objective:

The aim of this study was to determine whether the amount of total phenols is a good indicator
of the antioxidant activity of a species.

Methods:

The present study quantified the total phenols and antioxidant activity measured by DPPH
and ABTS methods of 18 species of Mediterranean scrubs and established the correlation between
these two parameters.

Results:

The obtained results showed that there was a wide variability in the content of phenols
among the analyzed species, with Cistus salviifolius and Nerium oleander presenting the largest and
smallest amount of total phenols, respectively (0.043 and 0.004 gallic acid equivalent (mg/mg dw)).
A cluster analysis differentiated these species into two groups with significantly different amounts of
phenols. The species that constitute Group I presented an average amount of 0.029 gallic acid equivalent
(mg/mg dw), and that of the species of Group II was 0.011±0.003 gallic acid equivalent (mg/mg
dw). The relationship between the antioxidant activity quantified in each species and its content of
total phenols showed a positive and significant correlation; however, when considering the two
groups of species, the significant correlation between these parameters depends on the species group,
the extract concentration used, and the method employed to quantify the antioxidant activity.

Conclusion:

These results indicate that it would not be correct to generalize that there is a significant
correlation between the amount of total phenols and the antioxidant activity. Therefore, total phenol
content cannot be used as a single indicator of the antioxidant activity of a species.
http://www.pjaec.pk/index.php/pjaec/article/view/1567
Authors: Bilal Muhammad ,   Department of Chemistry, Kohat University of Science and Technology , Kohat, Pakistan, Ali Javed , -ur-rehman Zia , Farooq Zahid , Khan Hizbullah
Published: July 2024

Humans' indiscriminate usage of heavy metals has a negative impact on the world's natural ecosystem. One of the main causes of contaminating the fresh and healthy atmosphere in rural Pakistan is the use of coal and soil in an improper manner by brick kilns. Different heavy metal concentrations and their impact on the surrounding areas of Pakistan's District Lakki Marwat were investigated in this study. Acid digestion methods were used to prepare samples, which were then examined using an Atomic Absorption Spectrophotometer. The concentrations of cadmium, iron, and lead in certain samples exceeded the WHO's permitted level, whereas nickel and zinc concentrations were within the limit. It was also discovered that the supply of raw materials is the key determinant in the buildup of heavy metals in the areas near brick not the age of the kiln.
Designing a sustainability monitoring system for the food and beverage industry in Indonesia using multidimensional scaling (MDS)
Authors: Rahman Barus Wan Habibi , Sriwana Iphov Kumala , Prambudia Yudha
Published: July 2024

The decline in the performance of the food and beverage sector by -3% for the food sector and -26.39% for the beverage sector in the second quarter of 2020 due to the outbreak of Covid-19 necessitated an analysis of the sustainability of the food and beverage industry. This research aimed to analyze the sustainability of the industry. A monitoring system for the sustainability of the food and beverage industry was an essential tool to ensure that the sector operated sustainably and contributed positively to the environment and society. Multidimensional Scaling (MDS) could be used to analyze and visualize the sustainability performance of the food and beverage industry based on various relevant dimensions or factors. The simulation results of Rapid Assessment of Food and Beverages (RAP-FB) indicated an overall high level of sustainability at 64.89%. In summary, the research showed that the food and beverage (F&B) industry's sustainability could be assessed through various dimensions and factors (such as Gross Domestic Product (GDP), energy efficiency, and workplace safety) contributed significantly to its overall sustainability. The monitoring system based on MDS could provide valuable insights to enhance the industry's performance and ensure its continued positive impact on the environment and society.
Penerapan Regresi dalam Menentukan Hubungan Fenologi terhadap Hasil pada Ercis (Pisum sativum L.)
Authors: Mubarok Amrul , Waluyo Budi
Published: July 2024

Ercis (Pisum sativum L.) merupakan tanaman legum yang tinggi nutrisi dan bernilai ekonomis tinggi. Namun, informasi terkait tahapan pada setiap fase hidup (fenologi) ercis masih tergolong rendah, padahal informasi tersebut dapat digunakan sebagai upaya peningkatan hasil panen. Tujuan penelitian ini ialah mempelajari hubungan fenologi terhadap hasil pada tanaman ercis (Pisum sativum L.) di dataran medium. Penelitian dilakukan dilahan percobaan Fakultas Pertanian Universitas Brawijaya, Jatimulyo, Malang, Jawa Timur. Penelitian dilakukan di bulan November 2022 – Januari 2023. Alat dan bahan yang digunakan ialah kebutuhan budidaya ercis serta menggunakan 3 genotipe ercis koleksi Universitas Brawijaya yaitu TMG-8-2, BTG-1, BW-44181-3-1. Penelitian ini menggunakan Rancangan Acak Kelompok (RAK) dengan 3 ulangan. Data yang diperoleh dilakukan analisis menggunakan regresi linear berganda. Hasil penelitian menunjukkan bahwa jumlah biji per tanaman sangat kuat dipengaruhi oleh jumlah daun, bobot biji per polong dipengaruhi secara kuat oleh waktu panen segar, bobot biji per tanaman dipengaruhi secara kuat oleh waktu berbunga 50%. Jumlah berbunga dipengaruhi secara kuat oleh tinggi tanaman, jumlah daun, jumlah ruas, waktu muncul daun > 9, dan waktu penuaan tanaman. Jumlah polong per tanaman dipengaruhi secara kuat oleh jumlah daun dan jumlah ruas. Jumlah biji per tanaman dipengaruhi secara kuat oleh jumlah daun, jumlah bintil akar dan waktu 50% berbunga
JENIS DAN PERSEBARAN AKTIVITAS PENGGUNA TAMAN HUTAN KOTA PATRIOT BINA BANGSA BEKASI
Authors: Mochamad Ariq Prayogo  , Johannes Parlindungan  , Deni Agus Setyono
Published: July 2024

Dalam kehidupan sehari-hari, ruang terbuka publik memiliki peran penting sebagai sarana atau lokasi bagi masyarakat untuk melakukan kegiatan yang dapat melepas penat. Taman Hutan Kota Patriot Bina Bangsa Bekasi merupakan salah satu ruang terbuka publik yang terdapat di Kota Bekasi. Taman ini masih memiliki kekurangan seperti kurang lengkapnya dan tidak terawatnya fasilitas yang ada pada taman ini. Hal tersebut dapat memengaruhi para pengguna taman dalam memanfaatkan taman ini. Tujuan dari penelitian ini adalah untuk mengetahui karakteristik dan jenis aktivitas yang dilakukan para pengguna Taman Hutan Kota Patriot Bina Bangsa Bekasi. Penelitian ini dilakukan dengan melakukan pengamatan terhadap perilaku pengunjung dalam memanfaatkan taman menggunakan analisis behavior mapping. Behavior mapping direpresentasikan sebagai sketsa atau diagram yang menunjukkan lokasi di mana orang-orang melakukan berbagai aktivitas. Hasil dari penelitian ini adalah teridentifikasinya karakteristik dan jenis aktivitas pengguna Taman Hutan Kota Patriot Bina Bangsa Bekasi.  Aktivitas pengguna yang paling banyak ditemukan berdasarkan hasil temuan pada taman ini adalah aktivitas mengobrol, dengan mayoritas pengguna taman adalah laki-laki, dan kelompok usia pengguna taman terbanyak adalah 26-45 tahun. Sebagian besar aktivitas pengguna taman berpusat pada area plaza taman, di mana area tersebut memiliki ruang yang cukup luas dan dapat dimanfaatkan untuk berbagai jenis aktivitas.
LIVABILITAS TAMAN-TAMAN KOTA DI KOTA BEKASI SEBAGAI RUANG PUBLIK
Authors: Rismania Putri Zelda , Surjono  , Agus Setyono Deni
Published: July 2024

Livabilitas ruang publik menjadi hal penting untuk mendorong kehidupan sosial kota dan meningkatkan kualitas hidup. Kondisi livabilitas ruang publik yang baik seharusnya dapat memberikan persepsi positif  bagi pengunjungnya. Namun, taman sebagai salah satu bentuk dari ruang publik seringkali gagal menyediakan aktivitas yang disukai dan tidak memenuhi kebutuhan penggunanya. Penelitian ini bertujuan untuk mengidentifikasi tingkat livabilitas taman kota di Kota Bekasi yaitu Taman Kota Alun-Alun, Taman Cut Meutia, dan Taman Bantargebang sebagai ruang publik berdasarkan kepuasan pengunjung terhadap atribut livabilitas ruang publik. Metode penelitian yang digunakan adalah analisis skoring untuk memperoleh penilaian kepuasan oleh pengunjung kemudian menormalisasi data dengan metode min-max normalization agar dapat mengadopsi indeks livabilitas oleh AARP. Hasil penelitian menunjukan bahwa Taman Cut Meutia dan Taman Bantargebang berhasil mencapai kondisi livable. Tingkat livabilitas kedua taman berada di kategori above average dengan nilai livabilitas masing-masing sebesar sebesar 66,80 dan 58,90. Kualitas Taman Cut Meutia dan Taman Bantargebang berhasil memberikan pengalaman positif bagi pengunjung.   Sementara itu, Taman Kota Alun-Alun belum berhasil mencapai kondisi livable. Tingkat livabilitas taman berada di kategori below average dengan nilai livabilitas sebesar 39,35. Kualitas Taman Kota Alun-Alun belum sepenuhnya berhasil memberikan pengalaman positif bagi pengunjung.
ASPEK PRIORITAS PENGEMBANGAN KEBERLANJUTAN KAMPUNG TENUN SAMARINDA SEBAGAI OBJEK WISATA BERBASIS BUDAYA
Authors: Sitaresmi Devi , Astha Dwinsani Pratiwi , Nabilla Diyah Hasari
Published: July 2024

Pada tahun 2012 Kampung Tenun ditetapkan sebagai kawasan cagar wisata budaya oleh Dewan Kerajinan Nasional. Keberlanjutan Kampung Wisata Budaya Tenun terdampak oleh pandemi Covid-19. Penurunan jumlah wisatawan akibat adanya pembatasan kegiatan mengakibatkan penurunan jumlah pendapatan masyarakat yang tinggal di Kampung Tenun. Selain itu, penurunan jumlah penenun diperkirakan akan terus terjadi dikarenakan sulitnya menemukan penerus, rendahnya minat wisatawan dan lamanya waktu produksi tenun serta kurangnya dukungan pemerintah akan pemasaran hasil tenun. Untuk menentukan aspek prioritas pengembangan kampung tenun, penelitian ini menggunakan analisis deskriptif kuantitatif menggunakan metode skoring. Berdasarkan hasil analisis ditemukan aspek prioritas pengembangan kampung tenun antara lain objek tangible, nilai sejarah, dan nilai sosial.
Tussen ervaringsdeskundigheid en mededogen. De verpleegkundigen van de laatste sanatoriumpatiënten in België, 1947-1986
Authors: Debroyer Tim
Published: July 2024

De introductie van antibiotica in 1947 transformeerde de behandeling van tuberculose en bracht bovendien een gestage leegloop van sanatoria met zich mee. Vrouwelijke patiënten kregen op dat moment de kans om een opleiding tot verpleegkundige te volgen binnen het sanatorium. Op deze manier werden ze een spilfiguur in de maandenlange sanatoriumbehandeling. Zo zagen ze toe op de inname van de antibiotica, maar stonden ze ook in voor het welzijn van de patiënt. De latere maatschappelijke stilte rond tuberculose maakte het voor deze verpleegkundigen echter uitdagend om dit verleden een plaats te geven.