bluuebunny/crossref_metadata_2025 huggingface dataset:
Implicaciones de la estructura organizacional
Authors: Gómez Vesga Juan Daniel
Published: February 2020

Introducción: el artículo de revisión es producto de la investigación “Implicaciones de la estructura organizacional: organizaciones como sistema de procesamiento de información”, desarrollada durante el 2017 en la Facultad de Ingeniería Industrial de la Universidad Distrital Francisco José de Caldas. Problema: en las organizaciones se evidencia que las estructuras jerárquicas son el paradigma predominante, a pesar de que investigaciones han mostrado la precariedad de este tipo de estructuras para el procesamiento de información. Objetivo: identificar los rasgos que permitan comprender la empresa como un sistema de procesamiento de información ágil. Metodología: se revisan los rasgos estructurales de los sistemas de procesamiento de información desde diferentes disciplinas. A partir de esta revisión se plantean las implicaciones de comprender a las organizaciones empresariales y en particular el diseño de la estructura como sistemas de procesamiento de información. Resultado: se desarrolla una apreciación sobre las implicaciones de diseñar estructuras con mayor agilidad en el procesamiento de información para la ingeniería organizacional. Conclusión: la comprensión de la organización empresarial, y en particular de la estructura como sistemas de procesamiento de información, ofrece una perspectiva ampliamente diferente del paradigma tradicional. Originalidad: la investigación se encuentra en etapas tempranas y no existen modelos o evidencias empíricas frente a los planteamientos realizados. Los altos niveles de agilidad en la toma de decisiones que exhiben las disciplinas estudiadas, permiten proyectar importantes líneas de investigación al respecto. Limitaciones: la propuesta se encuentra en la fase conceptual y requieren comprobación experimental.
Educação Empreendedora em Contabilidade: da Teoria à Aprendizagem Experiencial
Authors: Moreira Marcia Athayde , Alves Nadson Jaime Ferreira , Andreassi Tales , Braga Jorge Guilherme Rodrigues
Published: February 2020

O objetivo desta pesquisa foi o de avaliar o alcance da utilização de práticas intervencionistas em sala de aula de Graduação do curso superior em Ciências Contábeis na sensibilização de estudantes para o uso de instrumentos contábeis aliados ao aconselhamento empresarial. Metodologicamente, trata-se de uma pesquisa de natureza qualitativa, de cunho exploratório, realizada no âmbito da aprendizagem experiencial, com alunos da Graduação em Ciências Contábeis de uma IES Pública em um período de três meses. Os resultados mostraram-se satisfatórios, o processo de sensibilização foi completo, no qual estudantes de contabilidade puderam vivenciar a dura realidade dos pequenos empreendedores, destacando a grande contribuição que a Ciência Contábil pode oferecer. Assim, conclui-se com essa pesquisa que: a educação empreendedora é efetiva e possui potencial de desenvolver competências desejáveis em jovens em formação; a aprendizagem experiencial pode ser utilizada com sucesso no âmbito da educação empreendedora; a discussão sobre a educação empreendedora e o desenvolvimento de pequenas empresas brasileiras precisa envolver a contabilidade; e a combinação de educação empreendedora e prática experiencial pode reestruturar a prática docente com metodologias ativas de ensino-aprendizagem.
Análise financeira da seguridade e previdência social no Brasil em tempos de reformas fiscais
Authors: Botelho Luciano Henrique Fialho , Costa Thiago De Melo Teixeira da
Published: February 2020

Diante das divergentes discussões sobre o equilíbrio financeiro da seguridade social no Brasil, este artigo tem o objetivo de analisar a evolução e confrontação das receitas e despesas do Orçamento da Seguridade Social (OSS) no país, entre 2006 e 2016, com base nas regras de financiamento e ideal social propostos pela Constituição da República Federativa do Brasil de 1988. Ademais, procura-se debater os achados com as finanças públicas nacionais. Na revisão de literatura é abordado o Estado de bem-estar social e a seguridade social, seu custeio e sua relação com os indicadores econômicos e demográficos no Brasil. Metodologicamente, através de uma abordagem predominantemente quantitativa, utilizam-se análises gráficas, documentais, bibliográficas e estatísticas descritivas com dados secundários. Os resultados evidenciam a sustentabilidade financeira da seguridade social e a necessidade do entendimento do custeio tríplice e da unidade no OSS findando a valorização das políticas sociais, em especial a previdência social no regime geral. Fica clara ainda a importância dos cenários econômicos e da influência de outras ações fiscais (desvinculação das receitas da união e desonerações tributárias) no OSS. Conclui-se com a necessidade de uma reestruturação fiscal, com fortalecimento das bases econômicas, e não de reformas estruturais nas políticas sociais no Brasil, uma vez que as contribuições sociais ainda são relevantes para o financiamento do OSS, mesmo sendo necessárias algumas medidas na contenção de despesas.
Neural stem cell-conditioned medium ameliorates Aβ25–35-induced damage in SH-SY5Y cells by protecting mitochondrial function
Authors: Jia Guoyong , Diao Zengyan , Liu Ying , Sun Congcong , Wang Cuilan
Published: February 2020

Inhibition of amyloid β (Aβ)-induced mitochondrial damage is considered crucial for reducing the pathological damage in Alzheimer’s disease (AD). We evaluated the effect of neural stem cell-conditioned medium (NSC-CDM) on Aβ25–35-induced damage in SH-SY5Y cells. An in vitro model of AD was established by treating SH-SY5Y cells with 40 μM Aβ25–35 for 24 h. SH-SY5Y cells were divided into control, Aβ25–35 (40 μM), Aβ25–35 (40 μM) + NSC-CDM, and Aβ25–35 (40 μM) + neural stem cell-complete medium (NSC-CPM) groups. Cell viability was detected by CCK-8 assay. Apoptosis, reactive oxygen species (ROS) production, and mitochondrial membrane potential (MMP) were detected by flow cytometry. Malondialdehyde (MDA) content was detected by ELISA assay. Western blot analysis was used to detect cytochrome c release and apoptosis-related proteins. Transmission electron microscopy (TEM) was used to observe mitochondrial morphology. Cell viability significantly decreased and apoptosis significantly increased in SH-SY5Y cells treated with Aβ25–35, and both effects were rescued by NSC-CDM. In addition, NSC-CDM reduced ROS production and significantly inhibited the reduction of MMP caused by Aβ25–35. Furthermore, NSC-CDM ameliorated Aβ25–35-induced reduction in Bcl-2 expression levels and increased the expression levels of cytochrome c, caspase-9, caspase-3, and Bax. Moreover, Aβ25–35 induced the destruction of mitochondrial ultrastructure and this effect was reversed by NSC-CDM. Collectively, our findings demonstrated the protective effect of NCS-CDM against Aβ25–35-induced SH-SY5Y cell damage and clarified the mechanism of action of Aβ25–35 in terms of mitochondrial maintenance and mitochondria-associated apoptosis signaling pathways, thus providing a theoretical basis for the development of novel anti-AD treatments.
ЕСТЕСТВЕННЫЕ И ИСКУССТВЕННЫЕ ФАКТОРЫ КАВКАЗСКИХ ЭТНОКОНФЛИКТОВ
Authors: ALIMBARASHVILI İoseb
Published: February 2020

Современная русская историография старается доказать, якобы этноконфликты между кавказскими народами (В Абхазии. Южной Осетии (Цхинвальский регион); Карабахский конфликт между армянами и азербайджанцами; так называемый Назраньский конфликт между осетинами и ингушами, В Чечне) имеют исторические корни.
В реальности, на Кавказе и, вообще, в разжиганииэтноконфликтов и в дальнейшей “попытке” их урегулирования, главное слово принадлежит России, которая пыталась и пытается сохранить контроль в регионе по принципу “разделяй и властвуй”.
После августовской войны 2008 года, Россия признала независимость “Южной Осетии”и Абхазии. В то же время, т.н. “Северная Осетия” входит в состав России как автономная республика.
Ещё в 60-70гг. XIX века царская Россия абхазскому и северокавказским народам устроила фактический геноцид в виде “мухаджирства”, абхазов объявили “виновным народом”, а на их место были заселены русские или лояльно настроенное к власти другое население.
До 2008 года конфликты в Абхазии и Цхинвальском регионе представляли собой внутригосударственные конфликты, в которых друг другу противостояли, с одной стороны, центральная власть и, с другой стороны, “де факто” власть сепаратистских регионов. После августа 2008 года, когда Россия провела широкомасштабную военную агрессию и оккупировала 20% Грузинской территории, абхазский и Юго-Осетинский конфликты трансформировались в российско-грузинский конфликт.
Что касается конфликта Нагорного Карабаха, это спорная территория между Арменией и Азербайджаном. То же самое можно сказать о конфликте между осетинами и ингушами, где Россия официально играет роль посредника, в действительности же представляет собой заинтересованную сторону и реальное урегулирование конфликта не входит в его стратегические интересы. По поводу Чечни, это открытая агрессия против воюющей за свободу страны, которой до этого несколько раз (XIX в. 70-ые гг., 1944 г) устроил геноцид.
The language orientations of future mathematics teachers in the United States
Authors: Fernandes Anthony
Published: February 2020

Thirty-one preservice teachers at a university in the Southeast of the United States were interviewed regarding their beliefs about the teaching mathematics to English Learners. Ruiz’s (1984) framework of language orientations was used to understand their responses related to the use of the native language in the mathematics class. Four typologies that ranged from language-as-problem to language-as-resource were inferred. Implications for teacher preparation are discussed.
ANALYSIS OF RECREATIONAL AND TOURIST RESOURCES FOR THE NEED FOR AGRICULTURAL TOURISM DEVELOPMENT IN THE CARPATHIAN REGION
Authors: Penderecki Orest
Published: February 2020

The purpose of the study is to highlight theoretical and applied aspects of the issues of recreation and tourism resources of the Carpathian region for the needs of development of agro-industrial tourism.

Methods: The study used methods of comparison and generalization, logical methods, method of expert assessments, modeling, econometric and statistical methods.

Results: the policy of preservation, reproduction and effective use of recreational and tourist resources of the Carpathian region for the formation of agro-tourism in the context of balanced use of natural resources, restoration of natural ecosystems, maintenance of their integrity, improvement of the ecological situation for ensuring harmonious development and improving the quality of life of the population of the region are revealed.

Scientific novelty: The main provisions of the study represent a definite contribution to understanding the relationship between economic development and environmental safety, the use of recreational and tourist resources for the development of appropriate types of tourism.

Practical significance: It is possible to use the provisions and conclusions of the study as a theoretical basis for developing their own methods for assessing the effectiveness of specific types of tourism. The obtained data can be used to predict the expediency of tourism development in a particular region.
ANALYSIS OF THE IMAGE OF POLITICAL LEADER IN EXTENT CONSIDERATIONS OF CONTEMPORARY UKRAINIAN STUDENTS
Authors: Andrieieva Yaroslava , Lytovchenko Nina
Published: February 2020

The article is devoted to the socio-psychological analysis of the image of a political leader in the space of thinking of Ukrainian student youth. The problems of the implementation of the political choice of student youth in the process of socio-political changes are revealed. As politics began to be perceived as personalized, through the prism of personal characteristics of particular political figures, it is relevant to study the role of the image of a political leader, which is characterized by the transformation of personal and professional qualities. The paper presents a comparative analysis of the results of an empirical study of the image of a political leader in the space of thinking of student youth conducted at the Nizhyn Mykola Gogol State University and Yuriy Fedkovych Chernivtsi National University in 2011-2019. The article presents that formed image of the politician determines the level of political activity during elections. A comparative analysis of the results obtained concerning the priorities of student youth reveals the most important political quality of the political leader for student youth – his social orientation and concern for the people. The results of the comparative analysis indicate an increase in the political subjectivity of youth, but negative emotions (disappointment) impede the willingness for responsible participation in political life. Three groups of factors are identified that mediate the process of perception by the electorate of a political leader. Features of vertical and horizontal involvement of a citizen in political activity are revealed. The peculiarities of changing attitudes and the value-normative orientation of the political consciousness of modern students are demonstrated.
THE NATURE OF SYMPTOMS: FLUCTUATION OR RESPONSIBILITY AND FREEDOM INTERNALLY OF CHOICE
Authors: Kalishchuk Svitlana
Published: February 2020

The paper raises the issue of exacerbation of psychological problems caused by the political and economic environment, which creates a general social tension and becomes a background that exacerbates the existential problems of the individual. That's why author emphasizes on a particular need for the development of therapeutic direction and a detailed and well-grounded development of therapeutic concepts. It creates ways of an effective solve of current problems of psychological health and well-being of the person.

The article explained the conceptual provisions of the establishment, operation and therapeutic work with the symptom. The main characteristics, structure and overall symptom phenomenological expanse from the standpoint of the existential approach of the theory of system solutions and system modeling. Psychological functions of a symptom are considered. Issues of operationalization of a symptom and definition of conceptual provisions of its formation are solved . Basic rules of interpretation of a symptom and interpretation of the concept are described in terms of several approaches. The conceptual provisions of symptom formation that allow to include it in psycho-corrective methods are considered in detail.

The methods of the existential-systemic technological approach for providing psychological assistance to the client are analyzed and empirically tested, providing dynamic changes in the content of the "picture of the world" of clients in the cognitive and ontological plans. According to the empirical study, psychosomatic, emotional and behavioral symptoms were presented. It has been shown that symptoms with different specificities have unchanging constituents and functions. It also has been shown that applying an existential approach helps the symptomatic client to produce a new, better reality that will take into account the actual needs and aspirations of the subject. Thus, the main task, which is directed and work with the symptom – is the person's approach to himself/herself, greater sensitivity to his own real existential aspirations.
THE EMOTIONAL COMPONENT OF THE PRESENT-DAY STUDENTS' PSYCHICALLY HEALTH: THE QUESTION ANALYSIS
Authors: Kichuk Antonina
Published: February 2020

The investigation of the problem of the emotional component of the present-day students' psychological health is topical in some circumstances. Firstly, the dialectical character of the emotions and feelings correlation, the role of personal feelings in psychological health's general characteristic. The article also elaborates on the necessity of including the spheres of value and motivation into the overall theoretical and methodological context of discussing the outlined problem. The article also presents the results of empiric studies aimed at investigating the internal organization of the notion of psychological health in students of local universities. The results suggest that students give an exceptional value to the motivational dimension of psychological health. Also, the propositions for the future research in the field of psychological health are outlined. The article also provides a sufficient theoretical review of the notion of psychological health in literary sources.

The role of quantitative and qualitative emotional characteristics in personal alteration are important nowadays. The idea of the following theoretical constructs such as "psychological resource" and "psychological health" is investigated. Such principal term as students' age period in personal skills development, that is defined as an ability "to operate his/her resources" is analyzed.

The fundamental psychological researches confirm the importance of the role of the person emotional readiness in his/her development as an "integrated education" which involves not only the psychological health, but also the mental health and spirituality among other components. Such aspect of the problem is investigated in the context of a behavior-oriented approach, where the components are the following: person action that correlate with the phenomenal-emotional manifestation, that is operationalized as the transition of moral sense in philosophy and spiritual dimension.
THEORETICAL AND PRACTICAL ASPECTS OF MEASUREMENT AND EVALUATIONOF INTEGRATED CHARACTERISTICS OF PROFESSIONAL COMPETENCY OF THE PEDAGOGUE
Authors: Boyko Іrina
Published: February 2020

The article highlights the actual aspects of the interpretation of the notion of computation, competence, their use and priority directions of diagnostics of the components of professional competence of the teacher. The analysis of modern works on the competencies and competence as a multidirectional and variety of their characteristics is proved, which testifies to the very large complexity of their measurement and evaluation; an attempt was made to find ways to solve this urgent problem, which is connected with the improvement of the quality of education in the general context of its humanization. The aim is to highlight the individual professional qualities of the teacher: the general orientation of the motivational sphere, the degree of manifestation of a personal sense of professional freedom and abilities. these problems are coverage from the position of J. Raven and his emphasis on motivation and values of the individual. The role of the acmeological orientation of the individual is emphasized as an important factor in achieving pedagogical success. The acmeological orientation acts as a personal potential, which is a component of the individual psychological characteristics of the individual. The concept of personal potential has been developed in his works by D.O. Leontev and is interpreted as the ability of the individual to maintain the stability of activity under the influence of external conditions. An attempt has been made to gauge their specificity more deeply with the help of the Rorschach method. The general tendency is highlighted concerning the peculiarities of the study of the general orientation of the motivational sphere, the degree of manifestation of the personal feeling of professional freedom and abilities, which, in our opinion, is that it is relatively autonomous and its meaning lies in the field of determining the state and trends of the functioning of professional freedom, in general. Further searches are seen in solving the problem of developing effective methods for the professional diagnosis of the competence of educators in education and the creation of a continuous experimental system, which learns on the basis of own samples and errors, corrects its actions and initiates the forms of activity.
THE PROBLEM OF PERSONAL DEVELOPMENT OF EMPLOYEES OF THE STATE EMPLOYMENT SERVICE OF UKRAINE
Authors: Vlasova Olena , Kalenichenko Katherine
Published: February 2020

In the article the analysis of modern researches of the personality of employees of the state employment service has been carried out. The psychological aspects of the lack of desire for self-development and self-knowledge of employees of the State Employment Service of Ukraine are described. The 53 persons (38 of which have no higher education) are retraining at psychologist at the Institute of Personnel Training SESU) took part in the research. The revealed factors that have an influence on the indicator of personal self- development of the employees of the SESU: orientation in time, creativity and plasticity of behavior, empathy, emotional management, taking responsibility for their emotions, motivating achievement.
Some pharmacokinetics aspects of new analgetics from hexaazaisiowuritsitane class in rats
Authors: Lopatina Ksenya A. , Bryushinina Olga S. , Gurto Roman V. , Krylova Svetlana G. , Zuzkova Yulia G. , Kulagina Darya A. , Safonova Elena A. , Zueva Elena P. , Sysolyatin Sergey V.
Published: February 2020

An important stage in the preclinical study of a new drug is the study of its pharmacokinetics: absorption, distribution, metabolism, and excretion of the drug compound.

The purpose of this study was to study the pharmacokinetics in healthy animals of a new analgesic based on hexaazaisowurtzitane (thiowurtzine).

Materials and methods. A technique for determining the concentration of thiowurtzine in the blood plasma and rat excreta has been developed and validated. Using high-performance liquid chromatography and tandem mass spectrometry, concentrations of thiowurtzine in plasma and rat excreta were determined after a single intragastric dose of 100 mg/kg.

Results. The peak concentration of thiowurtzine in the blood plasma of rats accounts for 2 hours, which is consistent with the pharmacodynamic data of the analgesic, the average retention time of the substance in the body reached 17.15 h after administration. Thiowurtzine is believed to be actively metabolized.
The inhibitory effects of orexin antagonists on the reinforcing properties of amphetamine during brain self-stimulation and the development of a conditioned place preference in rats
Authors: Shabanov Petr D. , Azarenko Sergei V. , Morozov Vitalii I. , Bessolova Yulia N. , Lebedev Andrei A.
Published: February 2020

Purpose. In experiments on rats, we studied the self-stimulation reaction of the lateral hypothalamus and the conditioned reaction of place preference upon activation (orexin) and blockade of the orexin receptor by SB-408124 or Orexin B18-28 in rats.

Methods. As behavioral methods, self-stimulation of the lateral hypothalamus and a conditioned reaction of place preference were chosen. Orexin and its antagonists SB-408124 or Orexin B18-28 (Sigma, USA) were used for pharmacological analysis. All preparations were used in 3 dosages: 0.1, 1.0, 10 g, injecting into the lateral ventricle of the brain (i.v.) through the implanted cannula.

Results. It has been shown that peptide substances of orexin and its antagonists modulate the conditional and unconditional reinforcing properties of the brain. The studied orexin antagonists showed a dose-dependent (0.1-1-10 g, i.v.) inhibitory effect on the self-stimulation of the lateral hypothalamus, activated by indirect adrenergic agonist amphetamine (-phenylisopropylamine). The inhibitory effect of orexin antagonists also manifested itself in relation to the generation and expression of a preference for amphetamine place, especially when using high doses of the peptide (10 g i.v.).

Conclusion. The effect of orexin antagonists can be used in the development and study of antinarcotic drugs.
Statins as a component of lipid-lowering therapy
Authors: Danilov Andrey I. , Kozlov Sergey N. , Evseev Andrey V.
Published: February 2020

Statins are the main class of drugs that are used to treat patients with hyperlipidemia and atherosclerosis. Over the past decades, dozens of randomized clinical trials with this group of drugs have been conducted. Their results showed a significant reduction in cardiovascular and overall mortality, regardless of gender, age, baseline cholesterol levels. Currently, 6 drugs of this class are registered in the Russian Federation: Atorvastatin, Lovastatin, Simvastatin, Pravastatin, Rosuvastatin and Fluvastatin.
REVIVING THE INDIGENOUS KNOWLEDGE OF THE TENYIMIA NAGAS IN EASTERINE KIRE’S WHEN THE RIVER SLEEPS
Authors: Bhattacharya Panchali
Published: February 2020

Purpose: The purpose of the research is to acquaint the readers with the ideological episteme of the Naga theological dialectic which has always been suppressed by the dominant pedagogy of mainstream India. The study also aims to offer lessons in the management of complex land resources and livelihood through the consciously preserved and transmitted, cumulative, multigenerational Indigenous knowledge of the Naga community.

Methodology: The methodology is text-based interpretation, supported by the associated theoretical premise. A detailed critical analysis of Easterine Kire’s When the River Sleeps based on the theories of folk study and Indigeneity has been undertaken in the article.

Findings: The study brings to limelight the Indigenous knowledge base of the Tenimiyas and unveils the inviolability and regard these native people harbor towards their knowledge system. The paper provides a local answer to the global conundrum of perennial subjugation of traditional Indigenous knowledge. It also tries to legitimize the novelist’s tenability behind showcasing the necessity and relevance of Indigenous knowledge as a means to ensure the durability of the human race.

Implications: The new ethos propagated through my research will give primacy to the revival of the marginalized cultural ideology. Besides, a detailed study of Kire’s novel will enable critics and theoreticians of Indigenous studies to endorse the re-emergence of local knowledge of the aboriginal communities of Nagaland, since traditional Indigenous knowledge has always been perceived as inferior and naive by scientific developmental theories.

The novelty of the study: The readers get an opportunity to accustom themselves with a promising literary work from North-east India which evinces an inherent cultural resilience to preserve the body of knowledge that has been considered credulous, primitive and uncritical since ages. The paper also offers glimpses of the immensely rich and powerful folklores explicitly reflected in the narratives written by Indigenous Naga writers that form an intrinsic part of their collective archetype.
Eisini, hissini og kortini / Eisini, hissini and kortini
Authors: Weyhe Eivind
Published: February 2020

ÚrtakGreinin viðger tey trý føroysku hjáorðini, eisini, hissini og kortini, og lýsir málsøguliga framvøkstur teirra úr fornnorrønum til nútíðarføroyskt. Borið verður saman við norskt og íslendskt. Eisini og hissini eru hildin at koma av ávikavist norrønum eins veg(inn) og hins veg(inn). Kortini og fleiri síðuformar av tí mugu førast aftur til „hvárt (ið) er“ og „hvárt heldur (ið) er“. At enda í greinini verður tað adverbiella eftirfestið -ni umrøtt.AbstractThe article deals with the three Faroese adverbs eisini, hissini, and kortini, and traces their historical development from Old Norse to modern Faroese. Comparison is also made with Norwegian and Icelandic. Eisini and hissini are judged to come from Old Norse eins veg(inn) and hins veg(inn) respectively.Kortini and its several variants must go back to „hvárt (ið) er“ and „hvárt heldur (ið) er“. In conclusion the adverbial suffix -ni is discussed.
Wilt incidence in tomato genotypes (Solanum lycopersicum) in different production systems under shade mesh
Authors: Montiel-Peralta Edgar , Ávila-Alistac Norma , Montiel-Peralta Erik , Chamú-Baranda Juan Antonio
Published: February 2020

El objetivo del trabajo fue identificar el agente asociado a la marchitez y evaluar la incidencia en nueve genotipos de jitomate comerciales: seis genotipos con crecimiento indeterminado (Cid, Sun 7705, Moctezuma, Cuauhtémoc, Ramsés y Aníbal) y tres de crecimiento determinado (Palomo, Pony express y Toro). Los genotipos se evaluaron en cuatro sistemas de producción en malla sombra: suelo con acolchado, y tezontle en bolsas de plástico polietileno de 37x37, 40x40 y 40x45 cm. La incidencia de marchitez se evaluó a 114 días en 3,476 plantas. De acuerdo a características morfológicas in vitro en medio PDA y cámara húmeda, de 18/20 plantas se aisló únicamente un hongo del género Fusarium y en 2/20 se obtuvieron aislados de Fusarium y Rhizoctonia solani. La mayor incidencia se observó en los genotipos Cid (20.1%), Moctezuma (22.4 %) y Sun 7705 (29.7%) y la menor en genotipos de crecimiento determinado. El sistema de producción en bolsas 37x37 cm presentó la mayor incidencia de marchitez (25.9%) con rendimiento de 4.3 t ha-1; mientras que en bolsas 40x45 cm la incidencia fue menor (4.7%). En los cuatro sistemas de producción, el menor rendimiento se obtuvo con el genotipo Sun 7705 con producción en rango de 59.7 - 70.6 t ha-1.
NASOPHARYNGEAL CARRIAGE OF STREPTOCOCCUS PNEUMONIAE IN CHILDREN UNDER 5 YEARS OF AGE AFTER INTRODUCTION OF PNEUMOCOCCAL CONJUGATE VACCINATION IN THE REPUBLIC OF KHAKASSIA
Authors: Mirzaeva A. R. , Kulichenko T. V. , Lebedeva O. I. , Alacheva Z. A. , Kuznetsova T. G. , Alyabyeva N. M. , Brzhozovskaya E. A. , Mayanskiy N. A.
Published: February 2020

Introduction The dynamic study of the serotype composition and the level of antibiotic resistance of S. pneumoniae in different regions is the most important component of the control of pneumococcal infections (PI). The aim of the study was to analyze the serotype composition of S. pneumoniae isolated from the nasopharynx in children under 5 years of age, as well as to assess the sensitivity of pneumococci to antimicrobials, depending on the vaccination status and previous antibacterial therapy. Materials and methods A multicenter cohort study of nasopharyngeal carriage, serotype diversity and sensitivity to pneumococcal antibiotics were conducted in 13 centers in the Republic of Khakassia. Results 498 nasopharyngeal smears were collected, pneumococcus was isolated in 51.6% of cases. PI vaccination coverage in the cohort was 67.2%. The carriage of pneumococcus did not differ in children depending on their vaccination status (52.3% in vaccinated and 52.2% in unvaccinated). There was revealed a significant decrease in the carrier rate of pneumococcal vaccine serotypes in the cohort of vaccinated children compared with unvaccinated (17.6% vs 34.7%, p <0.05). High resistance of S. pneumoniae to penicillin (38.6%), macrolides (29.7%), trimethoprim/sulfamethoxazole (28.6%) was found. Amoxicillin resistance accounted for 20.8%, and ceftriaxone - 16.6%. Antibiotic-resistant vaccine serotypes were twofold more common. Conclusion The introduction of mass vaccination against PI in the country does not reduce the nasopharyngeal carriage of pneumococcus, but significantly reduces the circulation of vaccine serotypes, including strains resistant to antibiotics.
EXPERIENCE OF CARDIAC RESYNCHRONISATION THERAPY FOR DILATED CARDIOMYOPATHY IN YOUNG CHILDREN
Authors: Basargina Elena N. , Fisenko A. P. , Zharova O. P. , Gandaeva L. A.
Published: February 2020

The article represents the successful experience of using resynchronization therapy in young children with dilated cardiomyopathy associated with conduction disturbances. The intervention allowed reducing the heart failure symptoms and improving hemodynamic indices due to the reverse left ventricular remodeling. Resynchronization therapy is an effective modern invasive method for the treatment of chronic heart failure and can be considered as a method of treatment in patients refractory to drug therapy, including those referred for heart transplantation.
NEW DATA ON SUBCLINICAL MANIFESTATIONS OF SIDEROPENIC SYNDROME IN ADOLESCENT GIRLS
Authors: Peretyagina Natalya R. , Turovinina E. F.
Published: February 2020

To determine the functional state of the pituitary-thyroid system in conditions of iron deficiency in 371 girls aged 12-17 years was examined. The data of clinical blood tests, biochemical indices of iron metabolism, urinary iodine excretion, thyroid structure, and function are presented. Analysis of the seven-years observation in adolescent girls revealed a significant prevalence of iron deficiency conditions and euthyroid goiter. The iron deficiency in girls was found to increase the risk for euthyroid goiter formation by 10 times. Significant correlations were determined between thyroid volume indices, levels of thyroid-stimulating hormone (TSH), free thyroxine (cT4), the titer of antibodies to thyroid peroxidase (A-TPO) in blood plasma, changes in hemogram and iron metabolism. Violations of thyroid status and iron metabolism are subclinical manifestations of latent iron deficiency in adolescent girls, which are a risk group for the development of iron deficiency conditions. Iron deficiency has been proven to be a significant risk factor for the formation of euthyroid goiter in girls. In iron deficiency conditions in adolescent girls, structural and functional disorders of the thyroid gland should be excluded and its damage should be prevented.
Tight paths in convex geometric hypergraphs
Authors: Mubayi Dhruv , Füredi Zoltán , Verstraëte Jacques , Kostochka Alexandr , Jiang Tao
Published: February 2020

One of the most intruguing conjectures in extremal graph theory is the conjecture of Erdős and Sós from 1962, which asserts that every $n$-vertex graph with more than $\frac{k-1}{2}n$ edges contains any $k$-edge tree as a subgraph. Kalai proposed a generalization of this conjecture to hypergraphs. To explain the generalization, we need to define the concept of a tight tree in an $r$-uniform hypergraph, i.e., a hypergraph where each edge contains $r$ vertices. A tight tree is an $r$-uniform hypergraph such that there is an ordering $v_1,\ldots,v_n$ of its its vertices with the following property: the vertices $v_1,\ldots,v_r$ form an edge and for every $i>r$, there is a single edge $e$ containing the vertex $v_i$ and $r-1$ of the vertices $v_1,\ldots,v_{i-1}$, and $e\setminus\{v_i\}$ is a subset of one of the edges consisting only of vertices from $v_1,\ldots,v_{i-1}$. The conjecture of Kalai asserts that every $n$-vertex $r$-uniform hypergraph with more than $\frac{k-1}{r}\binom{n}{r-1}$ edges contains every $k$-edge tight tree as a subhypergraph. The recent breakthrough results on the existence of combinatorial designs by Keevash and by Glock, Kühn, Lo and Osthus show that this conjecture, if true, would be tight for infinitely many values of $n$ for every $r$ and $k$.

The article deals with the special case of the conjecture when the sought tight tree is a path, i.e., the edges are the $r$-tuples of consecutive vertices in the above ordering. The case $r=2$ is the famous Erdős-Gallai theorem on the existence of paths in graphs. The case $r=3$ and $k=4$ follows from an earlier work of the authors on the conjecture of Kalai. The main result of the article is the first non-trivial upper bound valid for all $r$ and $k$. The proof is based on techniques developed for a closely related problem where a hypergraph comes with a geometric structure: the vertices are points in the plane in a strictly convex position and the sought path has to zigzag beetwen the vertices.
Kentsel Yaşam Alanında Bitki Çeşitliliği ve Etkileri: Düzce Üniversitesi Konuralp Kampüsü Örneği
Authors: YAZLIK Ayse , KAVAK Mehmet , AŞKIN Esra , KÜLCÜOĞLU Nida , ERSOY Ömer , KOVANKAYA Furkan , DEMİRTAŞ Emrecan , AYDOĞDU Ayşenur
Published: February 2020

Yüksek insan nüfusu ve geniş yaşam alanları ile kentsel ekosistem kapsamında değerlendirilebilen üniversite kampüsalanlarının flora ve fauna yapısının tespiti ilgili alanların biyolojik çeşitliliğinin belirlenmesi bakımından önemlidir. Ayrıcailgili türlerin belirlenmesi çevresel ve sosyo-ekonomik etkilerin değerlendirilmesine bir kaynak sağlar. Bu çalışma, 2018-2019 yılları arasında otsu bitki türlerinin belirlenmesi ve etkilerinin tanımlanması konusunda Türkiye-Düzce ilinde bulunanDüzce Üniversitesi Konuralp Merkez Kampüsü’nde gerçekleştirilmiştir. Çalışmanın temel amacı, kampüs alanında bulunanotsu bitki türlerine karşı gerekli önlemlerin ve kontrol programlarının oluşturulması ve ilgili alanın biyolojik çeşitliliğininkorunması ve stratejilerin geliştirilmesi için bir kaynak yaratmaktır. Araştırma sonuçlarına göre; 27 familyadan 65 taksontespit edilmiştir. En fazla takson barındıran familyalar; Asteraceae, Poaceae, Fabaceae ve Cruciferae olarak sıralanmıştır.Taksonların yaşam süreleri incelendiğinde 33 takson tek yıllık, bir takson iki yıllık, 22 takson çok yıllık ve dokuz takson iseortak yaşam süresine sahiptir. Rastlanma sıklığına göre; Lamium purpureum ve Veronica persica % 84.4 ile en fazlarastlanılan türler olarak kaydedilmiştir. Bu türleri ise sırasıyla Anagallis monelli (% 81.2), Medicago arabica (% 72.0), Poabulbosa (% 72.0), Ranunculus repens (% 69.0), Plantago lanceolata (% 69.0), Conyza canadensis (% 66.0) ve Loliumperenne (% 66.0) takip etmiştir. Kampüs alanında belirlenen 65 taksonun farklı etki şekillerine sahip olması sonucu çevresel(68) ve sosyo-ekonomik (40) açıdan toplam 108 etki değerlendirilmiştir. En fazla etki şekli 34 taksonla güçlü üreme veyayılma etkisinde belirlenirken, bunu 26 takson ile peyzaj dokusuna etki takip etmiştir. Etki statüsü incelendiğinde ise 65olumsuz 43 olumlu etki tespit edilmiştir. Sonuçlar, kampüs alanlarında bulunan otsu bitki taksonlarının olumsuz etkileriniazaltmak için gerekli önlemlerin ve kontrol programlarının oluşturulmasına kaynak sağlayabilir. Ek olarak, olumlu etkilerive biyolojik çeşitliliği korumak için stratejiler geliştirilmesine yardımcı olabilir. Son olarak bu veriler gelecek yıllarda DüzceÜniversitesi yerleşke alanında otsu bitki taksonlarının değişimlerini izlemek için kullanılabilir.
Sorgum [Sorghum bicolor (L.) Moench] Genomunda BES1 Transkripsiyon Faktör Ailesinin Genom Çaplı Analizi
Authors: KASAPOĞLU Ayşe Gül , İLHAN Emre , KIZILKAYA Damla , HOSSEİN POUR Arash , HALİLOĞLU Kamil
Published: February 2020

BES1 transkripsiyon faktörü ailesi brassinosteroidlerin biyosentezinde önemli bir role sahiptir. Bitki büyüme ve gelişmesüreçlerini ve çevresel streslere yanıt mekanizmasını etkileyen bir steroid hormonudur. Bu çalışmanın amacı sorgum[Sorghum bicolor (L.) Moench] bitkisinin farklı dokularında farklı azot kaynakları (kontrol gübresi, amonyak, nitrat, üre)uygulanarak bu dokulardaki BES1 transkripsiyon faktörünün ifade profillerini belirlemek ve in siliko olarak BES1 genailesinin üyelerini genom çapında tespit ederek karakterize etmektir. Sorgum genomunda amino asit sayıları 190 ile 716,moleküler ağırlıkları 35.27 ile 80.54 kDa ve izoelektrik noktaları 5.0 ile 10.07 arasında değişen 9 Sobic-BES1 proteinibelirlenmiştir. Gen yapısı analizlerinde tahmini ekzonların sayısı 2 ile 10 arasında değişmiştir. S. bicolor, Arabidopsisthaliana ve Oryza sativa türlerinin BES1 proteinleri kullanılarak filogenetik ilişki tespit edilmiştir. Evrimsel süreçte Sobic-BES1-4 ve Sobic-BES1-9 genlerinin segmental duplike olduğu belirlenmiştir. İn siliko gen ifade analizlerine göre farklı azotkaynaklarının ve su kontrolünün uygulandığı kök ve sürgün dokularında Sobic-BES1-4 ve -9 genlerinin ifade seviyelerininen yüksek olduğu, diğer taraftan kullanılan azot kaynağına ve dokuya göre Sobic-BES1-1, Sobic-BES1-2 ve Sobic-BES1-8genlerinin ifade seviyelerinin farklılık gösterdiği belirlenmiştir. Bu çalışmanın sonuçları fonksiyonel gen araştırmaları içinbir temel sağlayacak olup, sorgum bitkisinde BES1 gen ailesinin anlaşılmasına katkı sunacaktır.
Analysis of ANC Levels after Filgrastim Therapy in Acute Leukemia Children with Neutropenia
Authors: Widya Reta Anggraeni , Nugroho Susanto , Winarsih Sri , Yulistiani Yulistiani
Published: February 2020

Cytotoxic chemotherapy suppresses the hematopoietic system, and the most serious hematologic toxicity is neutropenia. This can decrease a risk of infection that causes delays in treatment and reduction of dose intensity, which reduces therapeutic outcome. Filgrastim is used to increase neutrophils level whose therapeutic effect is unknown. The effectiveness of filgrastim is based on the ANC level pre- and post-therapy. This study aimed to analyze the use of filgrastim on ANC level changes in acute leukemia children with neutropenia, and to analyze the patient that achieve ANC level’s targeted therapy = 1000 cell/mm3. A prospective observational study with a longitudinal design was conducted from June to October 2016. The inclusion criteria of the study were patients who diagnosed acute leukemia with neutropenia and received filgrastim 10 µg/kgBW for 3, 4, 5 days. Patients’ ANC levels were measured before and after filgrastim therapy. This study has been approved its ethical clearance by Dr. Saiful Anwar Hospital, Malang. Data were obtained on the basis of neutropenic episodes, followed by 7 episodes of obtaining filgrastim for 3 days, 1 episode of obtaining filgrastim for 4 days, and 7 episodes of obtaining filgrastim for 5 days. Thus, it consists of 15 episodes. In 3 days, ANC levels increased by 9.5 fold from 381.3 ± 91.8 cell/mm3 to 3984.9 ± 426.8 cell/mm3, but in 5 days, ANC levels decreased by 0.9 fold from 200.9 cell/mm3 ± 98.2 to 189.7 ± 14.2 cell/mm3. Filgrastim was able to increased the ANC levels around nine fold for 3 days of theraphy. There were 53% neutropenia patients who achieved the goal of therapy. Filgrastim therapy with dose 10 µg/kgBW for 3 to 5 days has been able to reach the therapeutic target of 53% in acute leukemia children with neutropenia. The increased levels of ANC maximum was reached on the third day with increased levels of 9.5 fold.
Disease Free Survival of Stage I Endometrial Cancer after Surgery with or without Adjuvant Treatment
Authors: Moradokkasem Woraluk , Saeaib Nungrutai , Liabsuetrakul Tippawan
Published: February 2020

This study aimed to define the disease free survival (DFS) and factors associated with recurrence in stage I endometrial cancer after surgery with and without adjuvant treatment. The demographic data, pathological results, adjuvant treatment (AT) and the outcome of patients with endometrial cancer stage I after surgery in Songklanagarind Hospital between January 2002 and July 2014 were collected. The DFS was analyzed by survival analysis and represented by Kaplan–Meier curves. The difference of DFS between AT and non-adjuvant treatment (NAT) groups was tested by the log-rank test. Distributions of risk factors by AT and recurrent status were analyzed using chi-square or Fisher exact tests for discrete factors, and unpaired t or Wilcoxon rank-sum tests for continuous factors. The 5-year DFS was; 91.6%, from a total of 268 patients. DFS in the NAT group was significantly better than that in the AT group (95.2 versus 86.5%, p-value = 0.01). Factors associated with recurrence in the NAT group were age, tumor grading, tumor size, and presence of lymphovascular involvement. Among the AT group, age and ratio of myometrial invasion were associated with recurrence. DFS in NAT was better than in AT and the potential factors associated with recurrence, after surgery with or without AT, were not the same.
Determinant of Latent Pulmonary Tuberculosis Incidence among Health Workers in Community Health Centers in Surabaya, Indonesia
Authors: Andajani Susilowati
Published: February 2020

About 2 billion people in the world are infected with latent TB, and 5-10% of them will develop into active TB. The purpose of this study was to analyze the relationship between nutritional status, behavior, duration of work, comorbidities, and workplace ventilation with the incidence of latent pulmonary TB. This type of research is an observational cross sectional analytic, a sample of research of poly TB analysts and nurses from 13 health centers in Surabaya, a sample of 30 people. Statistical analysis with Chi Square and t-2 test samples were free with a=0.05. The results of this study are: The proportion of latent TB incidence is (46.70%) and 85.71% of them are women. None of the respondents detected DM, and none of the history had HIV, silicosis or hepatitis. All workplace ventilation is not good. There was no relationship between nutritional status, behavior, duration of work and the incidence of latent pulmonary TB. The conclusions from the study are, 1) The proportion of health center health workers affected by latent pulmonary TB infection is 46.70%, 2) There is no relationship between nutritional status, length of work, and behavior of health center health workers in Surabaya with latent pulmonary TB incidence. The highest incidence of latent pulmonary TB occurred in those with a working period of five years or more, with the highest education in D3 medical analysts/akper. All workplace ventilation is not good. The highest incidence of latent pulmonary TB (42.86%) in employees at the PRM Health Center (microscopic referral health center).
Comparison of PPT and APTT in Pre and Post-Hemodialysis Patients as the Heparin-Exposed Effect
Authors: Hernaningsih Yetti , Widodo Widodo , Aprianto Koko
Published: February 2020

Evaluations on Plasma Prothrombin Time (PPT) and Activated Partial Thromboplastin Time (APTT) are required in patients with Chronic Kidney Disease (CKD) stage V to determine the risk of bleeding after hemodialysis (HD) using heparin as the anticoagulant. This study aimed to compare the results of PPT and APTT in pre and post-hemodialysis patients with minimum dose of heparin. This was an observational-analytical study with cross-sectional design. The samples were collected in HD wards of Dr. Soetomo Hospital, Surabaya. There were 50 PPT and APTT samples collected from June to August 2017. The samples were evaluated using the tool CoaDATA 501. The examination of coagulation study was conducted in Clinical Pathology Laboratory of Dr. Soetomo Hospital, Surabaya. Paired t-test and Wilcoxon signed-rank test were performed in this study. In the 50 samples, pre-hemodialysis PPT ranged between 10.2-17.6 with the mean of 12.6±2.03 seconds, while for post-hemodialysis, the range was 10.1-20.9 with the mean of 13.41±2.43 seconds. Pre-hemodialysis APPT ranged between 19.5-75.2 with the mean of 30.32±10.43 seconds, while in post hemodialysis the range was 22.21-175 with the mean of 37.52±26.40 seconds. The results of PTT evaluation in pre and post-HD showed no significant difference (p=0.083), while those of APTT showed a significant difference (p=0.035 or p<0.05). Prolongation of APTT in post-HD is due to the use of heparin as an anticoagulant that increases PPT and APTT by inhibiting antithrombin III. HD procedures cause decreased activity of coagulation factors II, IX, X, XII leading to APTT prolongation in post-HD. A significant APTT prolongation was found in post-HD patients with CKD V.