bluuebunny/crossref_metadata_2025 huggingface dataset:
Characteristics of Hypertensive Patients at Sudiang Raya Public Health Center
Authors: Dahliah Dahliah , Darwis Nuari Aqriana , Azizah Nur Zamzam
Published: July 2023

Hypertension is one of the most common diseases found in primary medical practice. According to the NHLBI (National Heart, Lung and Blood Institution) 1 in 3 patients suffer from hypertension. Hypertension is also a risk factor for myocardial infarction, stroke, acute kidney failure and also death. The purpose of this study is to determine the characteristics of ARI patients in toddlers at the sudiang raya health center. description of the characteristics of hypertension in Puskesmas Sudiang Raya. Characteristics that are considered to consist of gender, age, and obesity. From 250 people it can be seen that the number of male patients with hypertension is 23 people (34.3%) and the number of female patients with hypertension is 44 people (65.7%). While the number of adolescent patients with age intervals of 12-16 years is 0 people (0%). The number of adult patients with age intervals of 26-45 years is 3 people (4.5%) and the number of elderly patients with an age interval> 45 years is 64 people (95.5%). While hypertension patients with normal BMI is 20 people (29.9%), overweight is 17 people (25.4%), obesity is 22 people (32.8%), and obesity II is 8 people (11 , 9)%). While the number of patients with normal hypertension (after routine care) is 9 people (13.4%), prehypertension is 31 people (46.3%), grade I of hypertension is 22 people (32.8%) and Patients with grade II of hypertension are free from 5 people (7.5%).
Overview of the Use of Communication Media as a Health Information Center
Authors: Burhanuddin Nurfardiansyah , Fajrin Muhammad Sofhyan , Zulfahmidah Zulfahmidah , Aisyah Windi Nurul
Published: July 2023

Background and Purpose: Health information actually aims to collect, store and make patient health information available and easily accessible when needed. The purpose of this study is to describe the use of communication media as a health information center. Methods: This study is a descriptive research design. Data collected using a questionnaire. The data of this research are categorical variables from several groups so that it uses the frequency distribution test. Reference search results are entered into the Mendeley app using the Vancouver system. Results: shows a total sample of 103 people aged 20 years 5 people (4.9%), 21 years 13 people (12.6%), 22 years 57 people (55.3%), 23 years 23 people (22.3%) and 24 years 5 people (5.9%). Based on gender, 88 people (85.4%) and 15 women (14.6%) were obtained. Conclusion: respondents often receive health information through social media, respondents also find it useful after getting information and users also usually continue to return health information received to other users.

Keywords: health information, students, health
Alignment and embodiment in a play script writing process: A sociocognitive perspective
Authors: Sagimin Eka Margianti , Sugiharto Setiono
Published: July 2023

Recent development in second language acquisition scholarship has advanced our understanding of how language is acquired by aligning the mind, body, and socio-material world.  Although many studies have been conducted from this perspective, more study on alignment focusing on writing a play script story in literature is needed. Drawing upon the idea of socio-cognitive alignment, this study investigated English literature student interactions during the process of writing a play script. It aims were to find out
how mind-body-world as socio-cognitive alignment could contribute to a meaning-making process during writing a play script.
A moment analysis was used as a method for analyzing data which were elicited from an audio/videotape recording and semi-structured interviews using a digital platform.  Results revealed that the integration of mind, body, and world was well-coordinated during the process of writing the play script. That is, the integration of mind-body-world was evident in how the students employed both verbal resources and other multimodalities in working with literary works and fiction. The study also demonstrated the importance of alignment and interaction for the development of fiction writing and language competence of EFL students.
Implementation of the Naïve Bayes Method to Determine Student Interest in Gaming Laptops
Authors: Nasution Rico Fadly , Dar Muhammad Halmi , Nasution Fitri Aini
Published: July 2023

The development of the times resulted in the development of technology to date. With the existence of technology, many people have used technology to help their daily activities. In this study, the author will discuss the technology that is often used by students to help them with their assignments, namely laptops. Laptop is a technology that has been widely used by students, teachers and the public. Having a laptop can make things easier. Until now, each laptop brand continues to develop their laptop production laptops with good specifications. Until now, almost all laptop brands have made gaming laptops that are actually intended for people-people who play games. But with good specifications, gaming laptops can also be used for daily activities. With an attractive design and good specifications, of course you can attract student and public interest in gaming laptops. Therefore the authors made a study of student interest in gaming laptops. With good design and specifications on gaming laptops, the author aims to classify the number of students who are interested and not interested in gaming laptops. The classification will be carried out using the Naïve Bayes method with the number of sample data used as many as 100 student data in data mining. The classification results obtained were 55 students (55% representation) interested in gaming laptops and 45 students (45% representation) had no interest in gaming laptops. The results show that not all students are interested in gaming laptops, even though they have laptops design and great specs.
E-Archive In Plaju Ulu Village Based On Web
Authors: Hartati Eka , Irawan Ari , Fatmariani Fatmariani , Yunifa Wiza
Published: July 2023

Abstract:The focus of this research is to design a Web-Based E-Archive in Plaju Ulu Village for services regarding E-Archives.The system development method uses the prototype method, while the system modeling uses Data Flow Diagram. This application testing is done using black box testing, where this testing is used to see done only observe the results of execution through test data and check the functionality of the software.The results of this research produce an e-archive application, and can provide information about any archives in Plaju Ulu Village, Palembang City. The system testing technique used in this study is black box testing, this test obtains input conditions for all functional needs of the program. Based on the test results ranging from admin features, incoming mail data features, outgoing mail data features, personnel data features, incoming mail archive features, outgoing mail archive features, all results are valid or successful. Users of this e-archive application consist of services, kasi, and lurah.

.Keywords: E-Archives, Data Flow Diagram, black box testing; application.
Performance Analyze of Fog Computing Against Topology Using YAFS Fog Simulator
Authors: Adiansyah Naufal Rafi , Karimah Siti Amatullah , Mugitama Satria Akbar
Published: July 2023

This research focuses on the analysis of fog computing performance on mesh, star, and ring topologies using the YAFS Fog Simulator. The reason YAFS (Yet Another Fog Simulator) was chosen was based on the consideration that this fog computing simulator, among other things, was designed to analyze topology and load balancing as well as include processing time for data transfer between devices into the fog layer. In addition, YAFS has a better level of time processing accuracy than other fog simulators. There are three test scenarios with additional load which includes 4, 8, and 12 fog nodes in each topology. Each scenario also has an additional load which includes 4, 8, and 12 devices in the form of sensors and actuators, respectively. The experimental results from the three scenarios show that the greater the load from the fog node and equipment, the longer the processing time will be. In addition, the results of the three scenarios also show that the mesh topology has the best time processing accuracy among the three tested topologies.
Study of Arrhythmia Classification Algorithms on Electrocardiogram Using Deep Learning
Authors: Arifin Rezki Fauzan , Mandala Satria
Published: July 2023

Arrhythmia is a heart disease that occurs due to a disturbance in the heartbeat that causes the heart rhythm to become irregular. In some cases, arrhythmias can be life-threatening if not detected immediately. The method used to detect is electrocardiogram (ECG) signal analysis. To avoid misdiagnosis by cardiologists and to ease the workload, methods are proposed to detect and classify arrhythmias by utilizing Artificial Intelligence (AI). In recent years, there has been a lot of research on the detection of this disease. However, many of such studies are more likely to use machine learning algorithms in the classification process, and most of the accuracy results still do not reach optimal levels in general. Therefore, this study aims to classify arrhythmias using deep learning algorithms. There are several stages of performing arrhythmia detection, namely, preprocessing, feature extraction, and classification. The focus of this research is only on the classification stage, where the Long Short-Term Memory (LSTM) algorithm is proposed. After going through a series of experiments, the performance of the proposed algorithm is further analyzed to compare accuracy, specificity, and sensitivity with other machine learning algorithms based on previous research, with the aim of obtaining an optimal algorithm for arrhythmia detection. Based on the results of the study, the Long Short-Term Memory (LSTM) algorithm managed to outperform the performance of other machine learning algorithms with accuracy, specificity, and sensitivity results of 98.47%, 99.24%, and 97.67%, respectively.
Ontology-Based Recommender System for Personalized Physical Exercise in Obesity Management
Authors: Muhammad Widi Sayyd Fadhil , Baizal Z. K. A , Dharayani Ramanti
Published: July 2023

In Indonesia, obesity is a serious health issue, and rates have risen recently because of sedentary lifestyles and poor eating practices. We suggest a proactive self-care suggestion system specifically created for Indonesians who are dealing with obesity to address this problem. Our recommender system attempts to give customers individualized suggestions for healthy lifestyle modifications that will make it easier for them to manage their weight. Because social media is so widely used in Indonesia, we created our system as a Telegram Chatbot. Our system may provide personalized suggestions based on a particular gender, activity level, fat mass, and difficulty of exercise that are relevant to Indonesians by fusing the user's ontological profile with generic clinical guidelines and standards for the management of obesity. Ontologies with Semantic Web Rule Language (SWRL) were used in the development of our system since SWRL ontologies are thought to perform better. Evaluations carried out using case studies and expert verification illustrate the usefulness of our suggested method, and the validated result of 88.8 percent demonstrates that our system can deliver good suggestion results for the user.
Decision Support System for Selection of Healthy Toddler using MOORA Method
Authors: Ulfah Auliana , Hasugian Abdul Halim
Published: July 2023

Toddlers are the human stage after infancy, toddlers are one of the most important stages in the quality development of human growth. one way to develop health in toddlers is to carry out routine checks at Public Health Center. Public Health Center has not yet provided a system for selecting healthy toddlers and also requires a system for selecting healthy toddlers. Therefore a decision support system is needed to make decisions related to checking the health of toddlers. decision support system is part of a computer-based information system, which is used to make a decision, in making a decision support system the Multi Objective Optimization by Ratio Analysis (MOORA) method is used. Based on the calculations made regarding the decision to check the health of toddlers, the MOORA method uses weighting criteria and determines the type of criteria, and MOORA does not have sub-criteria weighting provisions using FMADM, FMADM weighting reduces ambiguity because the bigger the value, the better, but if the value is too large then it is not good, such as body weight. It is necessary to provide more sub-criteria so that the accuracy in ranking is better and more accurate with a scale of 0-5. The optimization value for A1 is obtained by adding the cells from A1 0.6765 + 1.0070 + 0.2626 + 0.1195 = 2.0656 and Alternatives A2, A3, A15 have the most optimal weight values ​​with optimization values ​​(2.3282).
A Case of Maxillary Squamous Cell Carcinoma Transformed to Large Cell Neuroendocrine Carcinoma After Concurrent Chemoradiotherapy
Authors: Park Sang-Wook , Kim Minhye , Cho Hyun-Jin , Kim Sang-Wook
Published: July 2023

Large cell neuroendocrine carcinoma (LCNEC) is a poorly differentiated neuroendocrine carcinoma that typically arises in the lung. Because of its rarity and poor prognosis, standardized treatment has not been established yet. A 53-year-old male was initially diagnosed as a maxillary sinus squamous cell carcinoma (SCC) arising from inverted papilloma (clinical stage of T4bN2bM0, stage IVb), and underwent concurrent chemoradiotherapy. After achieving complete remission for 3 years, recurrent tumors were found, of whom the pathologic diagnosis turned out to be LCNEC. He underwent endoscopic transnasal tumor extirpation, followed by adjuvant concurrent chemoradiotherapy. Until postoperative 12 months, he showed no evidence of recurrence. To the best of our knowledge, this is the first report of maxillary SCC transformed to LCNEC after chemoradiotherapy.
Clinical Characteristics of Chronic Rhinosinusitis With Nasal Polyp According to Histopathological Endotypes and Staining Method for Neutrophilic Polyp Classification and Its Clinical Implication
Authors: Kim Hyoyeon , Yoo Shin Hyuk , Byun Kwang Hyun , Mo Ji-Hun
Published: July 2023

Background and Objectives There are various methods used to histologically assess the cell count of neutrophils in nasal polyps. With various classification of neutrophilic nasal polyps, determining the appropriate staining techniques and criteria is deemed important for the diagnosis of neutrophilic nasal polyps by assessing neutrophil cell counts. In this study, we tried to optimize different methods of neutrophil counting and staining by comparing clinical outcomes.Subjects and Method We studied 207 patients who underwent endoscopic sinus surgery for chronic rhinosinusitis with nasal polyp from August 2014 to September 2018. Patients’ nasal polyp were taken to make following three slide sections: hematoxylin and eosin, human neutrophil elastase (HNE), myeloperoxidase. After staining, microscope picture (×400) was taken and neutrophils were counted. Neutrophil polyp (NP) was classified either by the tissue neutrophil count (20/HPF) or by the neutrophil percentage (1%/total cell) for clinical outcome comparison.Results Two groups were made after HNE staining: the NP and the non-NP groups. The L-K scores and delta showed significant differences between each group while neutrophil was defined based on 20 counts/HPF (p<0.001). By Kaplan-Meier estimation, there was no statistical meaning between the two groups. But the NP group had a tendency to recur more than the non-NP group while 20 counts/HPF definition was used (p>0.05).Conclusion HNE staining and 20 counts/HPF were the most specific for neutrophil counting. Analyzing the nasal polyp into two groups due to histologic types showed that the NP group had worse prognosis than the non-NP group. In conclusion, neutrophils in the nasal polyp might be considered seriously for clinical outcomes.
MULTICULTURAL ISLAMIC EDUCATION VALUES IN THE INTERACTION OF SANTRI WITH CHINESE COMMUNITIES
Authors: Sholihuddin Moh
Published: July 2023

The Islamic boarding school is the oldest educational institution in Indonesia, as well as Kauman islamic boarding school of Lasem which founded in 2003. It is located in a multicultural environment, which peacefully coexists between people of different races, ethnicities and beliefs. This research aims to determine the values ​​of multicultural Islamic education that are resulted of the interaction of santri with Chinese communities. The approach used in this research is a qualitative approach with a phenomenological study. The data collection techniques were carried out by depth interview, observation and document analysis. Data analysis techniques used the Creswell phenomenological data analysis model, which includes; describing the phenomenon / experience that will be used as data, compiling a list of important statements to be grouped into important units or themes (data collection), writing textual descriptions (about “what”) and structural descriptions (about “how”), combining the two descriptions for compiled into a report. The results of this research are: the values ​​of multicultural Islamic education resulted of the interaction of santri with the Chinese community at Kauman Islamic boarding school of Lasem are adaptation, syafaqoh or compassion and caring.
THE ACT OF JIHAD ON HIGHER EDUCATION INSTITUTION AGAINST CORRUPTION
Authors: Wahid Abdul , Marwiyah Siti , Sunardi Sunardi
Published: July 2023

There is a paradoxical condition which afflicts higher education institution. On the one hand, higher education institution has proven itself as an educational institution which generates several knowledgeable and great people for the interest of Indonesian society and global community. However, another side of university is considered being affected by serious problems in relation with corruption in the state. Lots of notorious corruptors have already corrupted trillions of rupiahs from the state’s assets whereas these corruptors are higher education institution graduates. Moreover, there are many higher education institution elites who deal with law enforcement officials because they are alleged of doing corruption. A number of educational subjects in higher education institution were arrested by the Corruption Eradication Commission (KPK) because of their findings which indicate the misuse of government funds. Not only has it been regarded to physical construction of the higher education institution, but also the procurement of goods and services. Due to this condition, time has come for universities to promote educational jihad for the sake of corruption eradication in higher education institution.
CLASS TOGETHER IN REALIZING THE VALUES OF MODERATION OF ISLAMIC EDUCATION THROUGH MULTICULTURAL SCHOOL CULTURE
Authors: Firmansyah Firmansyah
Published: July 2023

Sultan Iskandar Muda High School in Medan under the auspices of The Sultan Iskandar Muda College Foundation located on Tengku Amir Hamzah Pekan I Sunggal Street, Medan Sunggal District, Medan Municipality. Sultan Iskandar Muda High School has its own uniqueness such as 1) Religion:religions recognized by the government such as Islam, Christianity, Buddhism, and Hinduism are in this school, Furthermore, mosques, churches, temples, and temples are built permanently in this school. 2) Â Culture:the diversity oflanguages, traditions, values, beliefs, myths, norms, and various tribes such as batak, Javanese, Chinese, Tamil, Mandailing, Malay, Karo, Aceh, Padang, Nias, Sunda, Banten Palembang, Ambon and Pakistan are in this school. Â This study aims Â first: Â to describe the values of moderation of Islamic education through multicultural school culture. This study uses qualitative type with Crasswell realist ethnography approach. Data collection techniques with participant observation techniques, in-depth interviews, and documentation. The result of this study is a joint class embodying the values of moderation of Islamic education through the culture of multicultural schools at SMA Sultan Iskandar Muda the first open values, secondly the value of dialogue, the third tolerance and the fourth is not extreme in religion.Keywords:Â  tolerance, dialogue, open and not extreme in religion
VALUE OF MULTICULTURAL ISLAMIC EDUCATIONAT PATRA DHARMA BALIKPAPAN HIGH SCHOOL
Authors: Kusnan Kusnan
Published: July 2023

This article aimed to describe value ofÂ  multicultural islamic educationat patra dharma balikpapan high school . Due to the fact that Patra Dharma Balikpapan High School as an educational institution located in a diverse social environment has an awareness of its responsibility in maintaining togetherness in diversity. This study was conducted as a case study in Senior High School Of Patra Dharma which in practice have instilled the values of multicultural Islamic education. To analyze the event by collecting data through Interview technique, Observation, Documents, Audiovisual And Digital Materials and narrated in the form of qualitative-descriptive with descriptive interpretative analysis. The results of this study indicated therefore diversity must be responded to in the concept of education. For the ability of this goal, it is a value that must be developed, and those values are the values of multicultural Islamic education. These values include; as-samhiyah (tolerance), Al-musawwa (equal rights), tawazzun (equality), and ta'awun (mutual help). The values of multicultural Islamic education are the capital of social values that are crucial in building togetherness in diversity.Keywords:Â  Values of Multicultural, Multicultural Islamic Education, Islamic Education
ISLAMIC EDUCATION CONSTRUCTION RAHMATAN LIL'ALAMIN IN THE PERSPECTIVE OF ISLAMIC RELIGIOUS FIGURES IN MALANG
Authors: Abrori Ali Mukhammad
Published: July 2023

The Islamic Society of Malang, has pattern various forms of worship and da'wah . Diversity this , in one aside bring goodness , because with diversity that , will add treasure science islam . Diversity method worship as well as a model of da'wah , can cause internal divisions of Muslims , if no be addressed by wise and wise . As effort ward off affiliated Islamic movement with radicalism and takfiri, some religious leaders in Malang indeed must campaign Rahmatan's Islamic Da'wah Lil'Alamin . In this case , there are several problems that are the focus of research as well as destination in research , namely (1) What is the view of Malang Islamic religious leaders about the concept of Islamic education Rahmatan Lil'Alamin? (2) How is the process of adapting the Islamic religious leaders in Malang, carrying out the process of realizing the teachings of love in the context of Rahmatan Lil'Alamin's Islamic education? (3) How do Islamic religious leaders in Malang carry out the process of internalizing the values of Rahmatan Lil'Alamin's Islamic education? . For that in writing dissertation this , author use type approach qualitative. From result study this that the figures have differences and similarities in views about the definition and concept of Islamic education Rahmatan Lil'Alamin . Meanwhile, the points of similarity regarding Rahmatan Lil'Alamin's concept of Islamic education are: Muslim leaders agree that every human being must spread love to all of God's creatures. Every citizen of different ethnicity, religion, race, and class, must live, tolerate each other, love one another. In the midst of the diversity of sects and understandings, Islamic religious leaders have carried out a process of adjustment and embodiment in relation to Rahmatan Lil'Alamin's Islamic education. In relation to the internalization process, how these figures provide real guidance to the Muslim community, in relation to Rahmatan Lil'Alamin's Islamic education.Keywords:Â  Islamic Education Construction, Rahmatan Lil'Alamin, Perspective Islamic religious figures.
EXTERNALIZATION OF THE MULTICULTURAL ISLAMIC EDUCATION CURRICULUM AT SCHOOL
Authors: Sulistiono Muhammad , Maskuri Maskuri , Arief Nur Fajar
Published: July 2023

This research discusses the externalization ofÂ  multicultural Islamic education which has the same wedge in the realm of learning, namely a contextual approach.Â  So that externalization is a process of material association with application in everyday life, namely returning to the values that guide the life of the community. The search for multicultural values that became the foundation for the founding of the school. Then it turned into a guideline by the citizens of the school that reflected the experience of multicultural values.Â  Furthermore, it is used as a foundation in the multicultural Islamic religious education curriculum. Based on the researcher's findings on the focus of research on the externalization ofÂ  the multicultural Islamic education curriculum in schools which includes several aspects, namely; (1) the phenomenon of ideas, (2) the phenomenon of history, (3) the phenomenon of the reaction of society, (4) the phenomenon of social products.Keywords:Â  externalization, curriculum, multicultural Islamic education
DECISION ANALYSIS ON IMPLEMENTATION OF PRIORITY CARE AND MAINTENANCE DUE TO POTENTIAL DAMAGE AT ALFAMIDI MINIMARKET IN MALANG USING THE AHP METHOD
Authors: Prabowo Adi , Nemesius Bambang Revantoro  , Cynthia Permata Dewi
Published: July 2023

The decision on the priority for care and maintenance at Alfamidi Minimarket uses the AHP method to evaluate the decision for building care and maintenance to predict any potential damage to Alfamidi Minimarket. Thus, numerous complaints may be reduced, and building quality can be maintained to assure customer safety and comfort while shopping at Alfamidi Minimarket. The objectives of this research are as follows: (1) to determine the condition analysis of Alfamidi Minimarket in Malang, (2) to obtain a priority scale for implementing care and maintenance at Alfamidi Minimarket in Malang using the AHP method and Expert Choice V.11 Application modeling. This research applied a quantitative approach with a descriptive analysis technique; the sampling procedure was purposive sampling, and 13 Alfamidi Minimarkets in Malang served as the sample. The subjects of the research were Alfamidi and shop employees. The data collection method used a form about the building condition and a priority weighting questionnaire as supporting data. The Analytical Hierarchy Process (AHP) method can be utilized in making decisions since it systematically has multi-criteria properties to describe a problem. The analysis results show that: (1) The average condition of Alfamidi Minimarket in Malang based on the building condition index shows a good category with a percentage of 82.0669% with an average architectural component index (IKK) of 77.8%, a structural IKK of 97.75 %, Utilities IKK was 88.28%, and Environmental Management IKK was 63.0%. (2) According to the priority results, Alfamidi Dieng had the lowest building condition index at 78.99%, while Alfamidi Sigura-Gura had the highest at 85.82%
Keywords: Priority; Care and Maintenance Building; AHP Method.
OPTIMIZATION OF WATER RESOURCES UTILIZATION DISTRIBUTION FOR AGRICULTURAL BENEFITS IN THE CLAMPIS IRRIGATION AREA SAMPANG DISTRICT
Authors: Zabadi Fairus
Published: July 2023

Utilization of water resources and management is an important factor and has a decisive role in order to increase production per plant in general and crop production in particular. In order to maintain self-sufficiency in food, it is necessary to make efforts to continuously increase the intensity of potential food crops. These efforts include optimizing the proper distribution of water utilization. Factors to determine the need for irrigation water include land preparation, consumptive use, percolation and seepage, replacement of water layers, and effective rainfall. While the method used in this study is optimization using a linear program using the Solver facility in Microsoft Excel with the aim of optimizing the availability of irrigation water so as to produce maximum profits and distribution of irrigation utilization that is more effective and efficient. From the optimization results using the Solver and Microsoft Excel tools, it can be seen that the maximum area of ​​land that can be planted with the available inflow at the intake for MTI (Rice I 2086 Ha/Tobacco II 667.54 Ha), MT-II (Rice I 667, 54 Ha/Tobacco I 1391 Ha/PolowijoI 567.35 Ha/Rice II 128.11 Ha), MT III (Polowijo I 323.65 Ha/Rice II 348.89 Ha/Tobacco II 1261.46 Ha/Polowijo II 825, 00) and provides an analysis of the maximum profit of agricultural products of Rp. 178,183,800,000.00,-.
 
Keywords: Linear Program Optimization; Utilization of Water Resources; Agricultural Benefits; Klampis Irrigation.
ANALYSIS OF TRAFFIC ACCIDENTS ON RAYA PELTONG ROAD – ARTODUNG PAMEKASAN DISTRICT
Authors: Wasiluddin  , Fatoni Ahmad , Fairus Zabadi
Published: July 2023

The Peltong-Artodung Highway, Pamekasan Regency has a high accident rate, a length of ± 2 km, and an effective road width of ± 6 m which is an area that has enough potential for the movement of traffic flow because it is a connecting road between Pamekasan City and Sumenep City, along the way there are also offices, schools, markets, shops, and residential areas. This analysis was conducted to determine the causal factors that influence the occurrence of traffic accidents. The data needed in this analysis consists of primary data and secondary data. Primary data consists of street names, number of lanes, lane widths, and LHR obtained from direct survey results in the field. The secondary data needed is a map of the research location, and data on traffic accidents. The data obtained is then analyzed by classifying accidents based on the factors that cause traffic accidents. The main factor in traffic accidents on Jalan Raya Pelting-Artodung (Jl. Lintas Pamekasan-Sumenep) is human beings, the age of the most traffic accident victims is 16-30 years old, the largest number of accidents occur at 06.00 to 20.00 as many as 63 .44% which is rush hour and the work of the accident perpetrators is dominated by men. Efforts that can be made to reduce the number of accidents on Jalan Raya Peltong-Artodung (Jl. Lintas Pamekasan-Sumenep), namely: providing traffic education and strict sanctions for road users who violate traffic rules and the installation of signs must be by Decree of the Minister of Transportation No. 61 of 1993 concerning Traffic Signs.
Keywords: Peltong-Artodung Highway; Accident Characteristics; Victims.
ISOIMPERATORIN-MEDIATED ANTICANCER ACTIVITY: ROLE OF MITOCHONDRIAL DYSFUNCTION IN HEPG2 CELLS
Authors: ERGÜÇ Ali , ARZUK Ege , ALBAYRAK Gökay , KARAKUŞ Fuat , OKUR Hayati , BAYKAN Şüra
Published: July 2023

Objective: The first goal of the present study is to investigate the role of mitochondria due to the Crabtree effect in HepG2 cells exposed to ISO in either glucose- or galactose-conditioned media. The second aim is to predict the interactions between electron transport chain (ETC) complexes and ISO, which might be the possible reason for mitochondrial dysfunction.
Material and Method: Cell viability and membrane damage for HepG2 cells exposed to ISO (12.5, 25, 50, 100, and 250 µM) were assessed by MTT and LDH leakage assays in either glucose- or galactose-conditioned media. The affinity of ISO to ETC complexes was also determined by a molecular docking study.
Result and Discussion: MTT assay showed that 250 µM ISO leads to cytotoxic activity in glucose-conditioned media, while 25 µM and higher concentrations of ISO decrease cell viability in galactose-conditioned media. A membrane damage assay conducted in a glucose-conditioned media assay revealed that 250 µM ISO disrupts the cell membrane. 100 and 250 µM ISO increased membrane damage in galactose-conditioned media. According to docking simulations, binding affinities of ISO to ETC complexes are in descending order: Complex IV > Complex I > Complex III > Complex II. Inhibition of complex IV by ISO inhibits the transfer of electrons from cytochrome c to oxygen, and the proton gradient collapses. The present study proposed that ISO leads to mitochondrial dysfunction via inhibition of the ETC.
EFEKTIVITAS SIPRAJA DI DESA SUGIHWARAS KABUPATEN SIDOARJO
Authors: Oribel Felicia , Wibawani Sri
Published: July 2023

Inovasi pelayanan publik diharapkan meningkatkan efektivitas dan efisiensi pelayan publik. Kabupaten Sidoarjo meluncurkan inovasi pelayanan dalam bentuk aplikasi SIPRAJA. Desa Sugihwaras memiliki komitmen yang kuat untuk berinovasi digital dengan menggunakan SIPRAJA. Namun, masih terdapat kendala dari masyarakat dalam mengakses SIPRAJA dan masih terdapat masyarakat yang belum lancar menggunakan aplikasi SIPRAJA. Selain itu kendala juga dialami oleh aparatur pemerintahan desa sebagai operator SIPRAJA yang masih kurang terampil di bidang digital karena mayoritas umurnya sudah cukup tua. Penelitian ini bertujuan untuk mengukur efektivitas SIPRAJA di Desa Sugihwaras Kabupaten Sidoarjo. Metode penelitian ini meggunakan metode kuantitaif dengan pendekatan deskriptif satu variabel yaitu efektvivitas SIPRAJA yang diukur dengan karakteristik inovasi menurut Rogers dan jumlah sampel 100 responden. Hasil penelitian ini menunjukkan bahwa indikator keunggulan relatif berada pada kategori sangat efektif, indikator kompatibilitas berada pada kategori sangat efektif, kerumitan berada pada kategori sangat efektif, kemampuan diujicobakan berada pada kategori sangat efektif, dan kemampuan diamati berada pada kategori sangat efektif. Sehingga menghasilkan kesimpulan efektivitas SIPRAJA di Desa Sugihwaras Kabupaten Sidoarjo berada pada kategori sangat efektif dengan nilai persentase 78%.
Behavioral changes and dendritic remodeling of hippocampal neurons in adolescent alcohol-treated rats
Authors: Sircar Ratna
Published: July 2023

Objective: Earlier, we and others have reported that alcohol exposure in adolescent rat impaired performance of a spatial memory task in the Morris water maze. The goal of the present study was to investigate the effects of acute adolescent alcohol treatment on the hippocampus-dependent (contextual fear conditioning) and hippocampus-independent (cued fear) memories. The study also looked at the structural changes in anterior CA1 hippocampal neurons in adolescent alcohol-treated rats.

Methods: Adolescent female rats were administered with a single dose of alcohol (1.0, 1.5, or 2.0 g/kg) or vehicle either before training (pre-training) or after training (pre-testing). Experimental and control rats were trained in the fear conditioning paradigm, and 24 h later tested for both contextual fear conditioning as well as cued fear memory. Separate groups of rats were treated with either alcohol (2 g/kg) or vehicle and sacrificed 24 h later. Their brains were harvested and processed for rapid Golgi staining. Randomly selected CA1 pyramidal neurons were analyzed for dendritic branching and dendritic spine density.

Results: Pre-training alcohol dose-dependently attenuated acquisition of hippocampus-dependent contextual fear conditioning but had no effect on the acquisition of amygdala-associated cued fear. When administered following training (pre-testing), alcohol did not alter either contextual conditioning or cued fear memory. Golgi stained CA1 pyramidal neurons in alcohol treated female rats had reduced basilar tree branching and less complex dendritic arborization.

Conclusion: Alcohol specifically impaired hippocampal learning in adolescent rats but not amygdala-associated cued fear memory. Compared to vehicle-treated rats, CA1 hippocampal pyramidal neurons in alcohol-treated rats had less complex dendritic morphology. Together, these data suggest that adolescent alcohol exposure produces changes in the neuronal organization of the hippocampus, and these changes may be related to impairments in hippocampus-dependent memory formation.
Meta-analysis of the effect of low-protein diets on the growth performance, nitrogen excretion, and fat deposition in broilers
Authors: de Rauglaudre Théophane , Méda Bertand , Fontaine Simon , Lambert William , Fournel Sébastien , Létourneau-Montminy Marie-Pierre
Published: July 2023

In broilers, the effects of crude protein (CP) reduction on animal performance are heterogeneous. This could limit the use of this strategy in commercial farms despite its potential to improve the sustainability of production. The objective of this meta-analysis was to study the effect of lowering dietary CP in fast-growing broilers with a focus on growth performance. A database was built from 29 papers published after 2016, for a total of 106 trials and 268 treatments. To be included in the database, trials had to be iso-energy and iso-lysine. Trials in which the growth rate for the control treatment was below 90% of the genetic potential of the birds were not included. The effect of the CP level was analyzed by multiple linear regression, with the trial as a random effect. A subsample of 33 trials (AACON) met the recommended amino acid (AA)-to-lysine ratios for indispensable AAs. In this subdatabase, average daily gain and average daily feed intake were maintained when dietary CP was reduced. The feed conversion ratio increased by 1.3% when CP was reduced by a one percentage point. The same CP reduction decreased daily nitrogen (N) excretion by 10.4%, whereas N retention was not affected by CP. In conclusion, respecting the ideal protein concept with the use of feed-grade AA allows for a decrease in dietary CP and N excretion with a limited impact on growth performance.
Cardiovascular changes in the NZB/W F1 mouse model of lupus nephritis
Authors: Böhme Romy , Daniel Christoph , Ferrazzi Fulvia , Angeloni Miriam , Ekici Arif Bülent , Winkler Thomas H. , Hilgers Karl-Friedrich , Wellmann Ute , Voll Reinhard E. , Amann Kerstin
Published: July 2023

Background

Patients with systemic lupus erythematosus (SLE), an autoimmune disease, have a higher risk of cardiovascular (CV) disease and death. In addition, up to 40%–50% of SLE patients develop lupus nephritis (LN) and chronic kidney disease, which is an additional CV risk factor. Thus, the individual contributions of LN and other SLE-specific factors to CV events are unclear.

Methods

In this study, we investigated the effect of LN on the development of CV changes using the female NZBxNZW F1 (NZB/W) mouse model of lupus-like disease, with female NZW mice as controls. Standard serologic, morphologic, immunohistologic, and molecular analyses were performed. In a separate group of NZB/W mice, systolic blood pressure (BP) was measured during the course of the disease using tail plethysmography.

Results

Our data show marked CV changes in NZB/W mice, i.e., increased heart weight, hypertrophy of the left ventricle (LV) and septum, and increased wall thickness of the intramyocardial arteries and the aorta, which correlated with the progression of renal damage, but not with the age of the mice. In addition, systolic BP was increased in NZB/W mice only when kidney damage progressed and proteinuria was present. Pathway analysis based on gene expression data revealed a significant upregulation of the response to interferon beta in NZB/W mice with moderate kidney injury compared with NZB mice. Furthermore, IFI202b and IL-6 mRNA expression is correlated with CV changes. Multiple linear regression analysis demonstrated serum urea as a surrogate marker of kidney function and IFI202b expression as an independent predictor for LV wall thickness. In addition, deposition of complement factors CFD and C3c in hearts from NZB/W mice was seen, which correlated with the severity of kidney disease.

Conclusions

Thus, we postulate that the pathogenesis of CV disease in SLE is affected by renal impairment, i.e., LN, but it can also be partly influenced by lupus-specific cardiac expression of pro-inflammatory factors and complement deposition.
An investigation into teachers’ occupational well-being and education leadership during the COVID-19 pandemic
Authors: Duong Anh Chien , Nguyen Hong Nhung , Tran Anh , Trinh Thong Minh
Published: July 2023

Introduction

The COVID-19 pandemic has necessitated rapid adjustments by teachers to ensure effective education. This shift in circumstances has created a more challenging working environment for teachers, leading to growing concerns about their occupational well-being both nationally and globally. While adapting to change and sustaining professional well-being are crucial for teachers, it is equally important to address their well-being during the pandemic. This study aims to contribute to the existing literature by employing questionnaires and semi-structured interviews to explore the occupational well-being of in-service teachers in Hanoi, Vietnam. Additionally, it seeks to examine their perceptions of school leaders’ efforts to enhance teachers’ well-being during the COVID-19 pandemic.

Methods

Convenience sampling was utilized to collect questionnaire data from 103 in-service teachers and lecturers in Hanoi, Vietnam, between 2021 and 2022. Moreover, a purposive sampling approach was employed to select eight participants for semi-structured interviews. The questionnaires and interviews formed the primary methods of data collection for this study.

Results

The findings of this study indicate that, overall, the participants exhibited a moderate level of occupational well-being. It was also observed that the participants received support from school leaders in terms of professional development, flexibility, and well-being activities during the COVID-19 pandemic. These results provide valuable insights for teachers to understand their personal occupational well-being and contribute to institutional awareness.

Discussion

The outcomes of this study have significant implications for teachers and principals. They shed light on the promotion of teachers’ occupational well-being during this critical period. Furthermore, the study illustrates how education stakeholders can play a role in enhancing teachers’ well-being. The discussion delves into the importance of personal occupational well-being and institutional awareness, emphasizing the need for collaboration among various stakeholders to create a conducive environment for teachers.
Serum folic acid: an effective indicator for arteriogenic erectile dysfunction
Authors: Feng Xingliang , Mei Yangyang , Xie Pinpeng , Xing Zhaoyu , Wang Xiaogang , Cui Li , Xu Renfang
Published: July 2023

Background

The present study is the first to explore the correlation between serum folic acid (FA) level and penile arterial peak systolic velocity (PSV) as measured via penile color Doppler ultrasonography (PDU), which directly reflects endothelial function in the penile artery.

Materials and methods

A total of 244 consecutive erectile dysfunction (ED) patients and 72 healthy controls, recruited from the Andrology department and the Healthy Physical Examination Center of our hospital, respectively, from June 2020 to April 2022, were included in the study. Serum FA was measured in ED patients and healthy controls, and PDU examinations were conducted for all eligible ED patients. The Pearson method was used to evaluate the correlation between FA levels and PDU parameters in ED patients. A receiver operating characteristic (ROC) curve analysis was also performed to calculate the sensitivity and specificity of these parameters for prediction of arteriogenic ED.

Results

After the PDU test, the average serum FA level among patients diagnosed with arteriogenic ED was 8.08 ± 2.64 ng/ml, lower than the average of 10.78 ± 2.87 ng/ml among healthy controls. There were no statistically significant inter-group differences on any basic parameters, including age, body mass index, fasting blood glucose, total cholesterol, and triglyceride. For further analysis, we divided the arteriogenic ED group into three subgroups by PSV range to compare serum FA levels among these subgroups. The mean FA levels in each of these groups were 5.97 ± 1.51ng/ml, and 8.21 ± 2.37ng/ml, and 10.55 ± 2.56ng/ml, while the corresponding PSV values were 15.75 ± 2.39cm/s, 23.53 ± 2.19cm/s, and 32.72 ± 1.64cm/s. Overall, a positive correlation between PSV and FA level was found among patients with arteriogenic ED (r=0.605, P<0.001). Furthermore, when FA level was used, with a cut-off value of 10.045 ng/ml, as a criterion to distinguish patients with arteriogenic ED from healthy controls, the area under the curve (AUC) was 0.772 (95% confidential interval: [0.696, 0.848]), for a sensitivity of 0.611 and specificity of 0.824.

Conclusion

Serum FA level is positively correlated with PSV in ED patients, and has the ability to distinguish patients with arteriogenic ED from healthy controls. Taking these findings together, FA deficiency should be regarded as an independent risk factor for arteriogenic ED.
Predictors and a prediction model for positive fine needle aspiration biopsy in C-TIRADS 4 thyroid nodules
Authors: Yang Zhijie , Gao Xin , Yang Lu
Published: July 2023

Objectives

To screen out the predictors and establish a prediction model of positive fine needle aspiration biopsy (FNAB) in the Chinese Guidelines for Malignant Risk Stratification of Thyroid Nodule Ultrasound (C-TIRADS) 4 thyroid nodules, and this nomogram can help clinicians evaluate the risk of positive FNAB and determine if FNAB is necessary.

Methods

We retrospectively analyzed data from 547 patients who had C-TIRADS 4 thyroid nodules and underwent fine-needle aspiration biopsy (FNAB) at the Second Affiliated Hospital of Chongqing Medical University between November 30, 2021 and September 5, 2022. Patients who met our inclusion criteria were divided into two groups based on positive or negative FNAB results. We compared their ultrasound (US) features, BRAF V600E status, thyroid function, and other general characteristics using univariate and multivariate logistic regression analyses to identify independent predictors. These predictors were then used to construct a nomogram. The calibration plot, area under the curve (AUC), and decision curve analysis were employed to evaluate the calibration, discrimination, and clinical utility of the prediction model.

Results

Out of 547 patients, 39.3% (215/547) had a positive result on fine-needle aspiration biopsy (FNAB), while 60.7% (332/547) had a negative result. Univariate logistic regression analysis revealed no significant differences in TPOAb, TgAb, TSH, Tg, nodule location, sex, or solid status between the two groups (P>0.05). However, age, nodule size, internal or surrounding blood flow signal, microcalcifications, aspect ratio, morphology, and low echo showed significant differences (P<0.05). Multivariate logistic regression analysis was conducted to explore the correlation between potential independent predictors. The results showed that only age (OR=0.444, 95% Cl=0.296~0.666, P<0.001), low echo (OR=3.549, 95% Cl=2.319~5.432, P<0.001), microcalcifications (OR=2.531, 95% Cl=1.661~3.856, P<0.001), aspect ratio (OR=3.032, 95% Cl=1.819~5.052, P<0.001), and morphology (OR=2.437, 95% Cl=1.586~3.745, P<0.001) were independent predictors for a positive FNAB. These variables were used to construct a prediction nomogram. An ROC curve analysis was performed to assess the accuracy of the nomogram, and AUC=0.793, which indicated good discrimination and decision curve analysis demonstrated clinical significance within a threshold range of 14% to 91%.

Conclusion

In conclusion, 5 independent predictors of positive FNAB, including age (≤45 years old), low echo (yes), microcalcifications (yes), aspect ratio (>1) and morphology (irregular), were identified. A nomogram was established based on the above 5 predictors, and the nomogram can be used as a complementary basis to help clinicians make decisions on FNAB of C-TI-RADS 4 thyroid nodules.