bluuebunny/crossref_metadata_2025 huggingface dataset:
Telemedicine-Based Management of Oral Anticoagulation Therapy: Systematic Review and Meta-analysis
Authors: Braga Ferreira Letícia , Lanna de Almeida Rodrigo , Arantes Alair , Abdulazeem Hebatullah , Weerasekara Ishanka , Ferreira Leticia Santos Dias Norberto , Fonseca de Almeida Messias Luana , Siuves Ferreira Couto Luciana , Parreiras Martins Maria Auxiliadora , Suelen Antunes Núbia , Fonseca Cândido Raissa Carolina , Rosa Ferreira Samuel , Guerra Pezzini Assis Tati , Marques Pedroso Thais , Boersma Eric , Ribeiro Antonio , Marcolino Milena Soriano
Published: April 2023

Background

Oral anticoagulation is the cornerstone treatment of several diseases. Its management is often challenging, and different telemedicine strategies have been implemented to support it.

Objective

The aim of the study is to systematically review the evidence on the impact of telemedicine-based oral anticoagulation management compared to usual care on thromboembolic and bleeding events.

Methods

Randomized controlled trials were searched in 5 databases from inception to September 2021. Two independent reviewers performed study selection and data extraction. Total thromboembolic events, major bleeding, mortality, and time in therapeutic range were assessed. Results were pooled using random effect models.

Results

In total, 25 randomized controlled trials were included (n=25,746 patients) and classified as moderate to high risk of bias by the Cochrane tool. Telemedicine resulted in lower rates of thromboembolic events, though not statistically significant (n=13 studies, relative risk [RR] 0.75, 95% CI 0.53-1.07; I2=42%), comparable rates of major bleeding (n=11 studies, RR 0.94, 95% CI 0.82-1.07; I2=0%) and mortality (n=12 studies, RR 0.96, 95% CI 0.78-1.20; I2=11%), and an improved time in therapeutic range (n=16 studies, mean difference 3.38, 95% CI 1.12-5.65; I2=90%). In the subgroup of the multitasking intervention, telemedicine resulted in an important reduction of thromboembolic events (RR 0.20, 95% CI 0.08-0.48).

Conclusions

Telemedicine-based oral anticoagulation management resulted in similar rates of major bleeding and mortality, a trend for fewer thromboembolic events, and better anticoagulation quality compared to standard care. Given the potential benefits of telemedicine-based care, such as greater access to remote populations or people with ambulatory restrictions, these findings may encourage further implementation of eHealth strategies for anticoagulation management, particularly as part of multifaceted interventions for integrated care of chronic diseases. Meanwhile, researchers should develop higher-quality evidence focusing on hard clinical outcomes, cost-effectiveness, and quality of life.

Trial Registration

PROSPERO International Prospective Register of Systematic Reviews CRD42020159208; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=159208
Testing the Social Robot LOVOT´s Interaction With Adults With Autism and Mental Impairment: Preliminary Findings (Preprint)
Authors: Gregersen Lajla Holtebo , Dalskov Leisted Sofie , Samuelsen Frederik , Dinesen Birthe
Published: April 2023

BACKGROUND

Persons with autism and mental impairment face communicative, social, and behavioral challenges, and there is a need to establish effective interventions to improve the quality of daily life. Social robots working with children with autism have successfully improved their communication and social behavior and reduced stereotypic behavior. However, there is only limited evidence regarding the effectiveness of social robots.

OBJECTIVE

This study aimed to investigate the interactions, effects on well-being, experiences from health care professionals, and ethical aspects of deploying the LOVOT social robot as a tool for adults with autism and mental impairment.

METHODS

Two social robots have been deployed in 3 residences. A total of 12 adults with autism and mental impairment were recruited. Individual planned sessions on interaction with the social robots are being carried out twice a week for 20-30 minutes over a period of 6 months. Participant observations are carried out every second week during the 6 months on themes such as well-being, interaction with the robot, the level of arousal, eye contact, and communication. Observations have been documented through standardized observation protocols and by video recording. Experiences from health care professionals and ethical aspects have been explored using semistructured interviews.

RESULTS

Preliminary results indicate that LOVOT has improved the well-being of participants. Although the participants’ interest in LOVOT varies, the health care professionals report that some participants find great satisfaction interacting with LOVOT, describing LOVOT as a friend, and that LOVOT can provide comfort in stressed situations. Two LOVOTs were damaged by the participants during the study, indicating the importance of robust material in interventions with adults with autism and mental impairment.

CONCLUSIONS

Preliminary findings indicate that social robots can increase well-being among persons with autism and mental impairment.  Future care of persons with autism and mental impairment might benefit from the use of social robots as part of their care and quality of life.
Telehealth Challenges for California Rural Hospitals in Reaching Latino Populations During COVID-19 (Preprint)
Authors: Mauricio Noemi , Newhart Glen , Herber Steven , Ahumada-Newhart Veronica
Published: April 2023

BACKGROUND

Rural and remote communities were especially vulnerable to the COVID-19 pandemic due to the availability and capacity of rural health services. Research has found that key issues surrounded (1) the lack of staff, (2) the need for coordinated health services, and (3) operational and facility issues. Similarly, research also confirms that irrespective of hospital capacity issues existing during crisis, compared to urban communities, rural communities typically face poorer access to health services. Telehealth programs have long held promise for addressing health disparities perpetuated by inadequate health care access. In response to the current COVID-19 pandemic, Adventist Health Saint Helena Hospital, a rural hospital in northern California, urgently worked to expand telehealth services. However, as Adventist Health Saint Helena Hospital is the longest-serving rural hospital in the state of California, administrators were also able to draw on experiences from the pandemic of 1918/1919. Understanding their historically rural and heavily Latino populations, their telehealth approach was coupled with cultural approaches for prioritizing socially responsive and equitable access to health services.

OBJECTIVE

This study aimed to present one rural community’s holistic sociotechnical response to COVID-19 in redesigning their health care delivery approach. Redesign efforts included the expansion of digital health services coupled with county-wide collaborations for nondigital mobile health centers, testing, and vaccination clinics to meet the needs of those with limited digital access and language barriers.

METHODS

We present data on telehealth services for maintaining critical care services and a framework on the feasibility of private-public partnerships to address COVID-19 challenges.

RESULTS

In this paper, we provide a critical review of how a rural hospital adapted its health care approach to incorporate telehealth services and distance services to meet the needs of a diverse population.

CONCLUSIONS

This paper contributes empirical data on how rural communities can use telehealth technologies and community partnerships for a holistic community approach to meet health needs during a natural disaster.
Recovery of Breakthrough Asthma Attacks Treated With Oral Steroids While on Monoclonal Antibody Therapy: Protocol for a Prospective Observational Study (BOOST) (Preprint)
Authors: Howell Imran , Mahdi Mahdi , Bafadhel Mona , Hinks Timothy S C , Ramakrishnan Sanjay , Melhorn James , Jabeen Maisha , Pavord Ian D
Published: April 2023

BACKGROUND

Asthma attacks are a common and important problem. Someone experiences an asthma attack in the United Kingdom every 10 seconds. Asthma attacks cause coughing, wheezing, breathlessness, and chest tightness and are highly stressful for patients. They result in reduced quality of life, with days lost from work or school. Asthma attacks are treated with oral corticosteroids (OCSs), but these have many short- and long-term side effects. Asthma monoclonal antibodies (mAbs) have revolutionized the treatment of severe asthma by reducing asthma attacks and OCS burden by over 50%, but some people still experience attacks while on mAbs. The MEX study showed that residual asthma attacks are broadly eosinophilic (high fractional exhaled nitric oxide [FeNO]) or noneosinophilic (low FeNO), but it did not measure response to OCS treatment. There is an evidence gap in understanding the clinical and inflammatory responses that occur when using OCSs to treat residual asthma attacks in patients taking asthma mAbs.

OBJECTIVE

The primary objective is to compare the clinical recovery between high-FeNO and low-FeNO attacks after acute treatment with oral prednisolone among people established on long-term asthma mAb treatment. The exploratory objective is to compare the inflammatory response to acute treatment with oral prednisolone between high-FeNO and low-FeNO attacks.

METHODS

BOOST (Breakthrough Asthma Attacks Treated With Oral Steroids) is a single-center, prospective observational study of 60 adults established on long-term asthma mAb treatment who receive acute treatment with oral prednisolone (usual care) for an asthma attack. The primary outcome will be the proportion of treatment failure (the need to start oral prednisolone or antibiotics or an unscheduled health care visit for asthma, following an attack) at day 28. The secondary outcomes will be the change in forced expiratory volume in 1 second and the change in visual analogue scale symptom score between the stable state, attack, day 7, and day 28 visits. The exploratory outcomes include the changes in sputum, nasal, and blood inflammometry between the stable state, attack, day 7, and day 28 visits.

RESULTS

The last asthma attack visit is anticipated to occur in December 2023. Data analysis and publication will take place in 2024.

CONCLUSIONS

We will test the hypothesis that there is a difference in the rate of recovery of clinical and inflammatory measures between high-FeNO and low-FeNO asthma attacks that occur in patients on mAb therapy. The study data will help power a future randomized placebo-controlled trial of prednisolone treatment for nonsevere attacks in patients treated with asthma mAbs and will provide important information on whether corticosteroid treatment should be FeNO-directed.

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/46741
Predicting Adherence to Behavior Change Support Systems Using Machine Learning: Systematic Review (Preprint)
Authors: Ekpezu Akon Obu , Wiafe Isaac , Oinas-Kukkonen Harri
Published: April 2023

BACKGROUND

There is a dearth of knowledge on reliable adherence prediction measures in behavior change support systems (BCSSs). Existing reviews have predominately focused on self-reporting measures of adherence. These measures are susceptible to overestimation or underestimation of adherence behavior.

OBJECTIVE

This systematic review seeks to identify and summarize trends in the use of machine learning approaches to predict adherence to BCSSs.

METHODS

Systematic literature searches were conducted in the Scopus and PubMed electronic databases between January 2011 and August 2022. The initial search retrieved 2182 journal papers, but only 11 of these papers were eligible for this review.

RESULTS

A total of 4 categories of adherence problems in BCSSs were identified: adherence to digital cognitive and behavioral interventions, medication adherence, physical activity adherence, and diet adherence. The use of machine learning techniques for real-time adherence prediction in BCSSs is gaining research attention. A total of 13 unique supervised learning techniques were identified and the majority of them were traditional machine learning techniques (eg, support vector machine). Long short-term memory, multilayer perception, and ensemble learning are currently the only advanced learning techniques. Despite the heterogeneity in the feature selection approaches, most prediction models achieved good classification accuracies. This indicates that the features or predictors used were a good representation of the adherence problem.

CONCLUSIONS

Using machine learning algorithms to predict the adherence behavior of a BCSS user can facilitate the reinforcement of adherence behavior. This can be achieved by developing intelligent BCSSs that can provide users with more personalized, tailored, and timely suggestions.
Topical Application of Tea Tree Oil for the Treatment of Verruca Vulgaris (Preprint)
Authors: Boopalan Deenadayalan , Vijayakumar Venugopal , Ravi Poornima , Kuppusamy Maheshkumar
Published: April 2023

UNSTRUCTURED
Impact of Telemedicine Modality on Quality Metrics in Diverse Settings: Implementation Science–Informed Retrospective Cohort Study (Preprint)
Authors: Rome Danielle , Sales Alyssa , Cornelius Talea , Malhotra Sujata , Singer Jessica , Ye Siqin , Moise Nathalie
Published: April 2023

BACKGROUND

Video-based telemedicine (vs audio only) is less frequently used in diverse, low socioeconomic status settings. Few prior studies have evaluated the impact of telemedicine modality (ie, video vs audio-only visits) on clinical quality metrics.

OBJECTIVE

The aim of this study was to assess telemedicine uptake and impact of visit modality (in-person vs video and phone visits) on primary care quality metrics in diverse, low socioeconomic status settings through an implementation science lens.

METHODS

Informed by the RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance) framework, we evaluated telemedicine uptake, assessed targeted primary care quality metrics by visit modality, and described provider-level qualitative feedback on barriers and facilitators to telemedicine implementation.

RESULTS

We found marginally better quality metrics (ie, blood pressure and depression screening) for in-person care versus video and phone visits; de-adoption of telemedicine was marked within 2 years in our population.

CONCLUSIONS

Following the widespread implementation of telemedicine during the COVID-19 pandemic, the impact of visit modality on quality outcomes, provider and patient preferences, as well as technological barriers in historically marginalized settings should be considered.
Effects of Gain-and-Loss framing Human Papillomavirus Vaccine Messages and Issue Involvement on Behavioral and Electrophysiological Measures of Attention and Implicit Attitudes: Event-Related Potential Study (Preprint)
Authors: Su Fang , Yang Ya
Published: April 2023

BACKGROUND

Human papillomavirus (HPV) is detrimental to genital and cervical health. gain-and-loss framing research has yielded limited findings regarding ways to systematically influence vaccine acceptance (uptake) and acceptability (attitudes and intentions) to promote the HPV vaccine. However, potential moderating variables need to be considered. This study was designed to overcome previous limitations by exploring the role of personal involvement with HPV issues and the gain-and-loss framework in cognitive effects through an electrophysiological study.

OBJECTIVE

The main objectives of this study were (1) to evaluate the effect of gain-and-loss frameworks on HPV immunization messages for college students with different levels of issue involvement on brain and cognitive processes, including attention and implicit attitudes, using behavioral and electrophysiological recordings (event-related potentials, ERPs); (2) to examine the cognitive process and attention allocation on gain-and-loss framing HPV messages and to further test the distinct persuasive routes of the elaboration likelihood model; and (3) to provide empirical evidence of design strategies for HPV immunization messages with regard to implicit social cognition bias about the different frames.

METHODS

In a mixed between-subjects experimental design, 40 participants were recruited into 2 (frames: gain vs. loss) × 2 (involvement: high vs. low issue involvement) groups. During the message exposure, brain activity was measured by electroencephalography as the participants were asked to conduct a 3-tone passive auditory oddball task. The amount of attention allocation was measured by event-related potentials (ERPs) (i.e., P300 amplitude) toward novelty stimuli. To further explore the implicit attitudes of the 4 groups, an implicit association test (IAT) was adopted and measured by D-scores.

RESULTS

For the P300 amplitude, the results showed that loss-framed messages elicited a larger P300 amplitude of novel stimuli than gain-framed ones (F1, 28 = 5.61, P=.03). The D-score results indicated that the IAT D-score of the gain-framed messages was also significantly higher than that of loss frames (F1, 36 =6.10, P =.02). Under the condition of the high-issue involvement group, the D-score of gain-framed messages was significantly larger than that of loss frames (P =.002).

CONCLUSIONS

The P300 effect suggests that gain-framed messages receive more attention from participants than loss-framed messages. The results of the IAT demonstrate that individuals with high-issue involvement are likely to find elaboration on gain-framed information. From the perspective of loss aversion, this study found a positive bias in health-promoting information: gain-framed messages tend to have more message elaboration than loss-framed messages and might arouse positive attitudes toward HPV vaccination.
The Role of Novel Digital Clinical Tools in the Screening or Diagnosis of Obstructive Sleep Apnea: Systematic Review (Preprint)
Authors: Duarte Miguel , Pereira-Rodrigues Pedro , Ferreira-Santos Daniela
Published: April 2023

BACKGROUND

Digital clinical tools are a new technology that can be used in the screening or diagnosis of obstructive sleep apnea (OSA), notwithstanding the crucial role of polysomnography, the gold standard.

OBJECTIVE

This study aimed to identify, gather, and analyze the most accurate digital tools and smartphone-based health platforms used for OSA screening or diagnosis in the adult population.

METHODS

We performed a comprehensive literature search of PubMed, Scopus, and Web of Science databases for studies evaluating the validity of digital tools in OSA screening or diagnosis until November 2022. The risk of bias was assessed using the Joanna Briggs Institute critical appraisal tool for diagnostic test accuracy studies. The sensitivity, specificity, and area under the curve (AUC) were used as discrimination measures.

RESULTS

We retrieved 1714 articles, 41 (2.39%) of which were included in the study. From these 41 articles, we found 7 (17%) smartphone-based tools, 10 (24%) wearables, 11 (27%) bed or mattress sensors, 5 (12%) nasal airflow devices, and 8 (20%) other sensors that did not fit the previous categories. Only 8 (20%) of the 41 studies performed external validation of the developed tool. Of these, the highest reported values for AUC, sensitivity, and specificity were 0.99, 96%, and 92%, respectively, for a clinical cutoff of apnea-hypopnea index (AHI)≥30. These values correspond to a noncontact audio recorder that records sleep sounds, which are then analyzed by a deep learning technique that automatically detects sleep apnea events, calculates the AHI, and identifies OSA. Looking at the studies that only internally validated their models, the work that reported the highest accuracy measures showed AUC, sensitivity, and specificity values of 1.00, 100%, and 96%, respectively, for a clinical cutoff AHI≥30. It uses the Sonomat—a foam mattress that, aside from recording breath sounds, has pressure sensors that generate voltage when deformed, thus detecting respiratory movements, and uses it to classify OSA events.

CONCLUSIONS

These clinical tools presented promising results with high discrimination measures (best results reached AUC>0.99). However, there is still a need for quality studies comparing the developed tools with the gold standard and validating them in external populations and other environments before they can be used in clinical settings.

CLINICALTRIAL

PROSPERO CRD42023387748; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=387748
Use of IQOSTM (A Heated Tobacco Product) in Italy: Results from Two Cross-sectional Studies (Preprint)
Authors: Roulet Steve , Pellegatti Tommaso , Magnani Pierpaolo , di Luzio Paparatti Umberto
Published: April 2023

BACKGROUND

Heated tobacco products (HTPs) such as IQOSTM are alternatives to cigarettes that heat rather than burn tobacco. Few data are available on the use of these products in Italy.

OBJECTIVE

To characterize how Italian adults use tobacco- and nicotine-containing products (TNPs), including smoke-free products such as IQOS, we surveyed Italian adults (users of legal age) about their current and past use of using smoke-free TNPs in from 2018 to 2020.

METHODS

We analyzed data from two consecutive cross-sectional surveys conducted in representative samples of the general adult population (6,095 subjects from 2018 to 2019 and 6,118 from 2019 to 2020) and IQOS users (1,371 subjects from 2018 to 2019 and 1,401 from 2019 to 2020) in Italy. We assessed the prevalence of current TNP use in the general population sample and the patterns of use in the IQOS users sample.

RESULTS

In the first cross-sectional study (2018-2019), cigarettes were the most used TNP (24.3%). Only small proportions used e-cigarettes or IQOS (1.4% and 0.7%, respectively). Nearly all current IQOS users were current adult cigarette smokers when they started using IQOS (98.0%). Some respondents used both IQOS and combustible TNPs (38.6%); however, most IQOS users (59.2%) exclusively used IQOS. Exclusive IQOS users reported improved respiratory symptoms (cough and phlegm) and exercise capacity compared to a year before they started using IQOS. Most current IQOS users also reported improved smell and taste, better smelling breath, and reduced teeth staining. Overall, these results were more pronounced among exclusive IQOS users. The results of the second cross-sectional study (2019-2020) were similar, except for a slight increase in IQOS use (1.1% vs. 0.7% from 2018 to 2019).

CONCLUSIONS

These studies show that most TNP users smoke cigarettes in Italy. The uptake of IQOS shows that it is a viable alternative to cigarettes; nearly all IQOS users switched from cigarettes to IQOS. Furthermore, most IQOS users exclusively use the product. Notably, respondents reported improved health, hygiene, and appearance after switching from cigarettes to IQOS.
Optimization of Polysorbate 80 and Sorbitan Monooleate 80 aas Emulsifiers in Foundation Makeup Containing Ethyl Cinnamate
Authors: Ungsari Rizki Eka Purwanto  , Intan Martha Cahyani  , Purwaningsih Yuliana , Sandhi Berliana Ganita Fatika , Febryana Fitria
Published: April 2023

Cosmetic foundation is a type of decorative makeup and commonly include a sunscreen agent. Ethyl cinnamate is one of the potential organic essential oil sunscreens. Nevertheless, there is little study on ethyl cinnamate usage in cosmetics, particularly oil-in-water foundation cream. Using an emulsifier in oil-in-water foundation cream a higher concentration does not guarantee higher oil phase recovery. However, using two combinations of emulsifier such as polysorbate 80 and sorbitan monooleate 80 with the optimum combination can be the right solution. This study aims to optimize polysorbate 80 and sorbitan monooleate 80 in a cream foundation using ethyl cinnamate as an active ingredient designed to have an effective ability to protect facial skin from ultraviolet radiation and are safe to use. The optimization formulas design of the emulsifier combination in foundation cream was made using the Simplex Lattice Design method with help Design Expert version 10.0.1. Parameter optimization were the value of pH, viscosity, spreadability, adhesion, and Sun Protection Factor (SPF) value. The stability test and skin irritation test of optimum formula were also conducted. As a positive control, Revlon Colorstay Foundation as a brand cosmetic foundation was used (National Food and Drug Agency of Indonesia number : NA18140300519). The optimum ratio of polysorbate 80 and sorbitan monooleat 80 were 9.565 and 1.435 with the physical characteristics of pH 6.478+0.008; viscosity 5844.2+31.82 cPs; spreadability 6.16+0.11 cm; adhesion 3.346+0.14 seconds; SPF Value 22.385+0.48, and no irritation symptoms. The ethyl cinnamate foundation created was physically stable, had a pleasing look, and did not irritate the skin, making it safe to wear. It also provides efficient UV radiation protection.
Screening Herbal Compound Candidates for Use as Anti-Inflammatory Drugs for COVID-19 Treatment Using Deep Semisupervised Learning
Authors: Khalid Irfan Alghani
Published: April 2023

COVID-19 is a disease caused by the SARS-CoV-2 virus. Its symptoms include cough, fever, shortness of breath, and acute inflammation (hyperinflammation), and severe cases can lead to death. These symptoms tend to worsen if inflammation is not controlled. This research aims to build a stacked autoencoder deep neural network (SAE-DNN) model for identifying herbal compound candidates that can be used as anti-inflammatory drugs for COVID-19 treatment. The model’s performance is evaluated on the basis of different data representations. The research process involves data collection, data preprocessing, modeling, and testing the model on the herbal data to obtain herbal compound candidates. Results indicate that the developed SAE-DNN model with compound representation that combines fingerprints and dipeptide composition produces the best performance with an accuracy of 0.96722, a recall of 0.96419, area under the receiver operating characteristic of 0.99596, and an F1 score of 0.96567. A total of 33 herbal compounds are found as candidate anti-inflammatory drugs by using the SAE-DNN model.
A bibliometric approach to preclinical studies of Tinospora crispa (L.) Hook. f. & Thomson as an antidiabetic
Authors: Arifah Fitriana Hayyu , Endro Nugroho Agung , Rohman Abdul , Sujarwo Wawan
Published: April 2023

The number of diabetes mellitus (DM) cases has increased, and Tinospora crispa (L.) Hook. f. & Thomson is recognized for treating DM. Despite publications on T. crispa as an antidiabetic, there were no bibliometric reports on this topic. Thus, this study aimed to conduct bibliometric studies of existing articles on the preclinical trials of T. crispa in DM management. We used Scopus to obtain a bibliographic database of primary research related to the topic. There were 24 selected publications between 1989 and 2019. Data were analyzed with VOSviewer 1.6.16. Malaysia, John Radcliffe Hospital (United Kingdom), Journal of Ethnopharmacology, Hamdan Noor, and Stephen J.H. Ashcroft (John Radcliffe Hospital, United Kingdom) were the most impactful country, institution, source, and author, respectively. The majority and diverse fields of this topic were phytochemistry and pharmacology. Our analysis’s findings strengthen research collaboration and identify research gaps required for herbal medicine applications.
Clindamycin peel-off mask film, an effective formulation for C. acnes treatment: characterization and microbiological activity
Authors: Morakul Boontida , Wongrakpanich Amaraporn , Teeranachaideekul Veerawat , Washiradathsathien Kritameth , Gamolvate Arkaratep
Published: April 2023

Clindamycin is the antibiotic of choice for treating Cutibacterium acnes (C. acnes) which was presented in various dosage forms such as topical solution, gel, and foam. In this current study, clindamycin was formulated as the peel-off mask gel, intending to form film, providing the drug release profile in a sustained manner leading to better antimicrobial efficacy and enabling peel-off after use. The peel-off mask gel was designed into many formulations with varying concentrations of film-forming agents. The major film-forming agent was 10 %w/w PVA that was combined with the additional film-forming agents PVP-K30 or SA. Clindamycin 1 %w/w was loaded in the selected formulations F18 (10 %w/w PVA and 20 %w/w PVP-K30) and F21 (10 %w/w PVA and 1.5 %w/w SA). The physical property evaluation of the peel-off mask gel showed that the types and concentrations of film-forming agents influenced the viscosity, spreadability, and film-forming ability. The film’s tensile strength indicating the preference of use was also determined. There was no interaction between the ingredients in the formulation evaluated by FT-IR, XRD, and DSC. The F18 and F21 formulations showed a good to very good spreadability and film-forming ability, a suitable tensile strength with a drying time of approximately 8 min, and pH 4-5. Both formulations provided the highest antimicrobial susceptibility for C. acnes compared to the blank film and the clindamycin solution indicating the potential to be developed as the new market formulation for acne treatment.
Modeling of Geological and Geophysical Data, Onshore Field of Potiguar basin, northeastern Brazil
Authors: Siqueira José Batista , Roberto Thaiane Kamila Alves
Published: April 2023

This work presents the results of 3D Geological Modeling with a focus on the onshore field, in the context of the Potiguar Basin. Therefore, the object of study is the silisiclastic reservoirs of the Açu Formation, unit 3, which correspond to the Albian/Cenomanian fluvial sandstones, in which hydrocarbon accumulations are housed. In this way, a better understanding of the reservoirs of a part of the field was sought through the integration of geological and geophysical information in the Leapfrog software. Where the gamma rays (GR), density (ROHB) and neutron porosity (NPHI) profiles were used to identify regions of reservoir rocks and sealants or non-reservoir. And the microresistivity profiles (MSFL), to determine the water saturation in the formation, and from that the oil saturation in the respective intervals. Through modeling, it was found that the highest relative oil saturation is accumulated in the upper portion of the sequence, in reservoir R1, where the average is 45%. In reservoir R2, intermediate, the average is 30% and in reservoir R3, in the lower part, 38%. And a total volume of hydrocarbons of the order of 1.17 MM3 was estimated for the three reservoirs. From this integration, despite the stage of production categorizing the field as mature, it appears that there are still significant volumes to be exploited.
Primary Education among Tribals of Jharkhand Need to be Strengthen
Authors: Chaudhary Dr. Amar Kumar , Tigga Alka Divya
Published: April 2023

Abstract: Tribal has substantial share to total population of Jharkhand. Tribals literacy rate is far below than other sections of society in Jharkhand. Sympathy or empathy, they need to be educated. The Govt. should give special package and special attention for their inclusive growth. Sustainable inclusive growth can be achieved only through education & specially the primary education among the tribal students to set their steps to-gather with the society, strengthen of primary education is sie que non for upliftment of tribals who are deprived from centuries
Online Heavy Equipment Booking
Authors: Patil Prof. Urjashree
Published: April 2023

Abstract: Heavy Equipment is an essential infrastructure industries. Traditional Equipment booking system such as phone, email and calls are time consuming, often leading to missed opportunities for both the customer and equipment rental companies. Online heavy equipment booking platforms have emerged as an alternative method that provides quick and easy access to rental equipment for construction and infrastructure projects. In a selected residential building construction project, Monte Equip mental simulation was applied for estimating the productivity on a construction site with selected parameters. The results reveal that scheduling heavy equipment and productivity are not given much consideration by Turkish construction enterprises, and their data on productivity only makes use of straightforward extrapolation for planned construction activities and daily papers from a machinery department. This paper briefly describes the features of the Turkish construction industry with reference to equipment scheduling and productivity evaluations in order to achieve significant cost reductions during construction projects. It also recommends simulation methods like Monte Equipment for estimating costs and productivity.
The Mediating Effects of Difficulties of Emotion Regulation between COVID-19 Stress and Depression of Undergraduate Students
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Jung Eun Sun , Lee Sung Won , Ha Jung Hee
Published: April 2023

Objectives The purpose of this study is to examine relations betweeen COVID-19 stress and depression, and examine the mediating effects of difficulties of emotion regulation among the undergraduate students. Methods Subjects were 426 undergraduate students who agreed to participate. For descriptive statistical analysis, Pearson analysis, and regression analysis by Baron & Kenny(1986) methods were performed using the IBM SPSS 21.0 program. Results First, it was found that COVID-19 stress and difficulties of emotion regulation showed a negative correlation with depression. In particular, among the sub-variables of COVID-19 stress, it was confirmed that fear of infection and difficulties due to distancing had a statistically significant effect on depression. Second, among the sub-variables of emotional control difficulty, lack of emotional attention/awareness, lack of emotional clarity, and limited access to emotion regulation strategies were found to have a statistically significant effect on depression. Third, it was confirmed that difficulties in emotion regulation partially mediating role in the relations between COVID-19 stress and depression. Conclusions Results of this study will be useful as basic data to understand the COVID-19 stress, difficulties of emotion regulation, depression among undergraduate students and to develop education program and help and support measures for clients.
ATIVIDADE APÍCOLA E A MORTANDADE DAS ABELHAS: RELATOS DA ASSOCIAÇÃO DE APICULTORES DE NONOAI/RS (AAPINO)
Authors: Fabris Bruna , Lucca Caovilla Maria Aparecida , Renk Arlene Anélia
Published: April 2023

O paradoxo da popularidade do uso de mel orgânico na alimentação humana encontra-se na escassez do ser vivo responsável pela sua produção: a abelha. Cresce, pois, a mortandade de abelhas e o uso de agrotóxicos nas monoculturas do país. Pretende-se verificar como este panorama se apresenta na realidade local. Por isso, o objetivo principal da pesquisa foi analisar os desafios enfrentados pela Associação de Apicultores de Nonoai/RS (AAPINO) no processo de produção de mel, assim como as consequências que a escassez das abelhas traz à apicultura. Os procedimentos metodológicos deram-se por meio de coleta de dados em pesquisa de campo do tipo comparativa, com entrevistas aos apicultores e representantes da Associação, além de visita ao entreposto e uso materiais bibliográficos. Entende-se que é primordial o engajamento de todos os atores do sistema alimentar (apicultores, agricultores, setor público, sociedade civil e consumidores) para que medidas de contenção da mortandade das abelhas sejam eficazes. Os apicultores da AAPINO apresentaram apreço pela atividade e consciência ambiental no manejo da atividade apícola, respeitando o compromisso de zelar pela saúde das abelhas.
MAPEAMENTO DAS POLÍTICAS PÚBLICAS RELACIONADAS ÀS MUDANÇAS CLIMÁTICAS NO CONTEXTO DA AGRICULTURA FAMILIAR NO BRASIL
Authors: Destefani Ferretti Kleber , Aparecida Ribeiro Nepomoceno Taiane
Published: April 2023

Com o aumento da intensidade dos eventos climáticos extremos em diversas regiões do planeta, surge a preocupação sobre o alcance das políticas públicas desenvolvidas para a agricultura familiar neste contexto. Portanto, o objetivo deste artigo foi mapear legislações brasileiras relacionadas à mudança climática e sua interface no contexto da agricultura familiar. Para isso, realizou-se uma revisão documental onde buscamos mapear quais as legislações e aparatos oficiais existentes que se relacionam à sustentabilidade, agricultura familiar e mudanças climáticas. O recorte temporal foi de 2017 a 2022, com buscas em quatro bases de dados online. Verificamos que no período analisado são escassos de dispositivos legais que discutem de forma aprofundada a mudança climática no contexto da agricultura familiar no Brasil. Sobretudo, é essencial destacar que apesar de numerosas as legislações analisadas, elas são limitadas a um debate ambiental conceitual cujo não assume uma posição ou indicação de ações efetivas à altura de estruturação de políticas públicas.
Análisis genético del bovino Criollo Mixteco de Oaxaca
Authors: Domínguez Martínez Miguel Ángel , Hernández Núñez Víctor , Mariscal Méndez Araceli , Martínez Martínez Amparo , Fuentes-Mascorro Gisela
Published: April 2023

El bovino Criollo Mixteco es un recurso genético poco explorado, pero de gran valor por su potencial para ser empleado en sistemas de producción respetables con el entorno y adaptables a las condiciones del mismo. La identificación y caracterización de este recurso local es un punto primordial para su conservación y mejora, es por esto que en el presente estudio se llevó a cabo el análisis de la diversidad y relaciones genéticas de la población de bovinos Criollos Mixtecos de Oaxaca, mediante el empleo de 19 marcadores de ADN microsatélites y 32 poblaciones bovinas de referencia, pertenecientes al consorcio BIOBOVIS de la Red CONBIAND. El número medio de alelos detectados fue de 8.8 ± 2.1 y el número efectivo de alelos estimado fue de 4.5 ± 1.2. La diversidad genética representada por los valores de heterocigosidad esperada (0.7700 ± 0.0682) y observada (0.7170 ± 0.0998), se encontró dentro del rango de estimadores obtenidos en estudios previos con poblaciones bovinas locales empleando marcadores microsatélites. El análisis de la estructura poblacional reveló una influencia predominante de germoplasma ibérico (Bos taurus). Se observa además una estrecha relación entre el Criollo Mixteco y el resto de poblaciones bovinas criollas mexicanas a excepción del Criollo Lechero Tropical.
How do Baitul Maal Wat Tamwil empower Micro, Small and Medium Enterprises amidst COVID-19 pandemic? A case of Indonesia
Authors: Ma'ruf Aminudin , Elmi Nur Azizah  , Jannah Arrum Sari
Published: April 2023

During the COVID-19 pandemic, Baitul Maal Wat Tamwil (BMT) in Sukoharjo, a region of Indonesia is consistently contributing to the empowerment of Micro, Small and Medium Enterprises (MSMEs). Hence, how the BMT empowers the MSMEs is a worthy attribute to explore. The current study delves into an in-depth exploration on the strategies and policy innovations carried out by the BMTs as well as to analyse the impact or influence caused by the existence of these strategies. The method used in this research is field research with a qualitative approach. Data collection techniques were carried out through observation with interviews with various related parties. The results showed that the empowerment strategy carried out by BMT Dana Mulia and BMT Makmur Mandiri was by implementing a restructuring policy in an effort to maintain the stability of the institution's operations. Meanwhile, BMT Bina Ummah Sejahtera has tightened risk mitigation by making efforts to be more careful in conducting financing and deposit transactions, using online media and the three BMTs providing business assistance. The influences that arise with this strategy are providing ease of capital assistance during the COVID-19 pandemic, assisting business development of MSMEs, minimizing the risks faced by MSMEs, and encouraging the spirit of MSMEs in marketing their businesses.
Mollification of Fourier Spectral Methods with Polynomial Kernels
Authors: G Chandhini , P Megha
Published: April 2023

Many attempts have been made in the past to regain the spectral accuracy
of the spectral methods, which is lost drastically due to the presence
of discontinuity. In this article, an attempt has been made to show that
mollification using Legendre and Chebyshev polynomial based kernels
improves the convergence rate of the Fourier spectral method. Numerical
illustrations are provided with examples involving one or more
discontinuities and compared with the existing Dirichlet kernel
mollifier. Dependence of the efficiency of the polynomial mollifiers on
the parameter P is analogous to that in the Dirichlet mollifier,
which is detailed by analysing the numerical solution. Further, they are
extended to linear scalar conservation law problems.
The Psychosocial Impact of the Kosovo War: A Systematic Review with Recommendations for Kosovar Patient Care
Authors: Jarrah Ryan M. , Vitija Xheneta , Kelmendi Fatjona , Pushani Frosilda , Isak Ergest , Ademaj Amarildo
Published: April 2023

Introduction: The Kosovo War is widely remembered as one of the
most brutal conflicts in the modern era. With over 13,000 deaths and
90% of the population displaced as refugees, the impact of the war has
led to everlasting levels of trauma that impacts the lives of thousands
of Kosovar-Albanians today. Objectives: To characterize the
psychosocial impact of the Kosovo war by comprehensively assessing the
literature to date. We also provide recommendations to improve outcomes
for Kosovar-Albanian patients in the post-war era. Methods: A
systematic review was conducted using post-war clinical psychological
articles on the Kosovo War. Our search involved utilizing full-text
English articles from PubMed, OVID Medline, and EMBASE journals.
Keywords used were “Kosovo War”, “Psychosocial”, and “Post
Traumatic Stress Disorder”. Results: Our post-traumatic stress
disorder (PTSD) analysis yielded a total of 10,134 responses from
participants ranging from refugees to the general public. Our results
showed 2,997 subjects (30%) who reported or met the criteria for
post-traumatic stress disorder. When analyzing refugee participants,
there was 1,133 with 60% of them meeting the PTSD criteria. In a
filtered cohort of 5,117 subjects measured for adverse events, 3,180
subjects (64%) of subjects had experienced combat, while 3,664 (74%)
were exiled from their homes. Conclusion: The psychosocial
impact of the Kosovo war is likely under-reported by patients due to
cultural stigmas, language barriers, and trust barriers with clinicians.
Factors such as age, employment, displacement status, number of
traumatic events, socioeconomic vulnerability, and health literacy are
associated with poor psychiatric morbidity.
Estimation of Model Accuracy in CASP15 Using the ModFOLDdock Server
Authors: McGuffin Liam , Edmunds Nicholas S. , Alharbi Shuaa M. A. , Genc Ahmet G. , Adiyaman Recep
Published: April 2023

In CASP15 there was a greater emphasis on multimeric modelling than in
previous experiments, with assembly structures nearly doubling in number
(41 up from 22) since the previous round. CASP15 also included a new
estimation of model accuracy (EMA) category in recognition of the
importance of objective quality assessment for quaternary structure
models. ModFOLDdock is a multimeric model quality assessment server
developed by the McGuffin group at the University of Reading, which
brings together a range of single-model, clustering and deep learning
methods to form a consensus of approaches. For CASP15 three variants of
ModFOLDdock were developed to optimise for the different facets of the
quality estimation problem. The standard ModFOLDdock variant produced
predicted scores optimised for positive linear correlations with the
observed scores. The ModFOLDdockR variant produced predicted scores
optimised for ranking, i.e., the top-ranked models have highest
accuracy. In addition, the ModFOLDdockS variant used a quasi-single
model approach to score each model on an individual basis. The scores
from all three variants achieved strongly positive Pearson correlation
coefficients with the CASP observed scores (oligo-lDDT) in excess of
0.70, which were maintained across both homomeric and heteromeric model
populations. In addition, at least one of the ModFOLDdock variants was
consistently ranked in the top two methods across all three EMA
categories. Specifically, for overall global fold prediction accuracy,
ModFOLDdock placed second and ModFOLDdockR placed third; for overall
interface quality prediction accuracy ModFOLDdockR, ModFOLDdock and
ModFOLDdockS were placed above all other predictor methods, and
ModFOLDdockR and ModFOLDdockS were placed second and third respectively
for individual residue confidence scores. The ModFOLDdock server is
available at:
[https://www.reading.ac.uk/bioinf/ModFOLDdock/](https://www.reading.ac.uk/bioinf/ModFOLDdock/).
ModFOLDdock is also available as part of the MultiFOLD docker package:
[https://hub.docker.com/r/mcguffin/multifold](https://hub.docker.com/r/mcguffin/multifold)
Patterns and trends in Chlorophyll-a concentration and phytoplankton phenology in the biogeographical regions of Southwestern Atlantic
Authors: Delgado Ana Laura , Hernández-Carrasco Ismael , Combes Vincent , Font-Muñoz Joan , pratolongo paula , Basterretxea Gotzon
Published: April 2023

The Southwestern Atlantic Ocean (SAO), is considered as one of the most
productive areas of the world, with high abundance of ecologically and
economical important fish species. Yet, the biological responses of this
complex region to climate variability are still uncertain. Here, using
24 years of satellite derived Chl-a datasets, we classified the SAO into
coherent regions based on homogeneous temporal variability of Chl-a
concentration, as revealed by the SOM (Self-Organizing Maps) analysis.
These coherent biogeographical regions were the basis of our regional
trend analysis in phytoplankton biomass, regional phenological indices,
and environmental forcing variations. A generalized positive trend in
phytoplankton concentration is observed, especially in the highly
productive areas of the northern shelf-break, where phytoplankton
biomass is increasing at an outstanding rate up to 0.42 ± 0.04 mg m-3
per decade associated with the sea surface temperature (SST) warming
(0.11 ± 0.02 °C decade-1) and the mixed layer depth shoaling (-3.36 ±
0.13 m decade-1). In addition to the generalized increase in
chlorophyll, the most sticking changes in phytoplankton dynamics
observed in the SAO are related to the secondary bloom that occurs in
most of the regions (15 ± 3 and 24 ± 6 days decade-1) which might be
explained by the significant warming trend of SST, which would sustain
the water stratification for a longer period, thus delaying the
secondary bloom initialization. Consistent with previous studies, our
results provided further evidences of the impact of climate change in
these highly productive waters.