bluuebunny/crossref_metadata_2025 huggingface dataset:
Performance evaluation of a Semivolatile Aerosol Dichotomous Sampler (SADS) for Exposure Assessment: impact of design issues
Authors: Rekeb Noredine , Sutter Benjamin , Belut Emmanuel , Géhin Evelyne , Olsen Raymond
Published: January 2024

Abstract. Aerosols of semivolatile organic compounds (SVOCs) pose significant health risks to workers in various occupational settings. Measuring human exposure to these aerosols requires a separate assessment of the contribution of particles and gases, which is not resolved by existing sampling techniques. Here, we investigate experimentally the performance of the Semivolatile Aerosol Dichotomous Sampler (SADS), proposed in previous studies, for sampling monodisperse liquid particles with aerodynamic diameters between 0.15 and 4.5 µm, corresponding to workplace aerosols. The measured sampling performances are compared to their theoretical counterparts computed by computational fluid dynamics. The effects of leakage rate, repeatability of the assembly, imprecision of the actually machined nozzle diameters and SADS parts misalignment are examined. The SADS assembly is found easily leaky, but consequences on sampling can be overcome when a prior leak test with leakage rate below 4 Pa.s-1 is passed. Variation of nozzle diameters in the range (-4.5 %, +3.7 %) with respect to nominal values affects marginally (<3 %) aerosol transmission efficiency, but sampling performance is little reproducible during successive SADS assemblies (CV=22.1 % for wall losses). Theoretically unpredicted large (40–46 %) wall losses are measured for particles larger than 2 µm, located mostly (80 %) on the external walls of the collection nozzle. Assembly repeatability issues and simulations of SADS parts misalignment effect by CFD suggest that these undesirable particle deposits are due to the mechanical backlashes of the assembly. Thus, the current design does not guarantee a nozzle misalignment of less than 5 % of the acceleration nozzle diameter, and other important geometric parameters are not further constrained. The promising theoretical sampling performance of the SADS for SVOCs aerosol larger than 1 µm thus falls short of expectations due to mechanical design issues that can be improved before possible field use.
Quasi Real-Time Tsunami Early Warning Assessment Based on Finite Fault models
Authors: Sifón Matías , Fuentes Mauricio , Riquelme Sebastian , Sánchez Rodrigo , Arriola Sebastian
Published: January 2024

Abstract. In Chile, Tsunami Early Warning relies on a precomputed set of scenarios for places near the tsunami generation zone. These scenarios are non-realistic and are computed from a uniform constant slip over the rupture surface, because of the short reaction time for the local authorities to manage the threat. Here, we present a new methodology that allows quasi-real time tsunami modelling using a finite fault model inversion to evaluate tsunami threat levels. A linear approximation at first order terms of the shallow water wave equations turns into a numerical solver that can be implemented on a programming language. As a case of study, the proposed method is applied in Chile. The results show that it is possible to obtain realistic threat levels and arrival times for the tsunami in progress. Once the finite fault is calculated, it takes a minute to produce the warning maps. The proposal considers realistic heterogeneous and kinematic fault models of seismic sources obtained rapidly using continuous GPS, strong motion and broadband records, expanding the evaluation capabilities of Tsunami Early Warning Systems. Using directly the finite fault avoids the unrealistic model of uniform slip distribution and diminishes the uncertainty imposed by precomputed scenarios.
Influence of rotor blade flexibility on the near-wake behavior of the NREL 5 MW wind turbine
Authors: Höning Leo , Lukassen Laura J. , Stoevesandt Bernhard , Herráez Iván
Published: January 2024

Abstract. High-fidelity computational fluid dynamics (CFD) simulations of the National Renewable Energy Laboratory (NREL) 5 MW wind turbine rotor are performed, comparing the aerodynamic behavior of flexible and rigid blades with respect to local blade quantities as well as the wake properties. The main focus has been set on rotational periodic quantities of blade loading and fluid velocity magnitudes in relation with the blade tip vortex trajectories describing the development of those quantities in the near wake. The results show that the turbine loading in a quasi-steady flow field is mainly influenced by blade deflections due to gravitation. Deforming blades change the aerodynamic behavior, which in turn influences the surrounding flow field, leading to non-uniform wake characteristics with respect to speed and shape.
Critical systems thinking for the design and improvement of complex social service program outcomes
Authors:   , McKenna Patrick
Published: January 2024

This research project applied the multimethodological approach of Critical Systems Thinking and Practice to improve outcomes for beneficiaries of Emergency Relief—a social service program funded by the Australian Government and delivered by 197 community service providers to assist people facing a financial crisis. The findings led to recommendations for providers to help strengthen referral systems and staff training, and for governments to avoid adverse unintended consequences resulting from ‘payment by outcomes’ commissioning and welfare conditionality. The research led to the creation of practical tools to assist providers and governments in the design and evaluation of integrated social services.
Cronología, tipología, ideología y prosoponimia plautinas
Authors: López López Matías
Published: January 2024

El presente estudio persigue analizar, de distintas formas, varias cuestiones plautinas de primer orden. El apartado de cronología somete a crítica los postulados teóricos de las principales autoridades en la materia y aporta una nueva -y razonada- ordenación de las comedias de Plauto. En los apartados de tipología e ideología, se ha buscado una síntesis capaz de ofrecer vías inéditas a la investigación. En cuanto a la prosoponimia, se sugiere una etiqueta identificativa más exacta para la categoría ‘nombre parlante’.
El locus a nomine y su funcionamiento en la literatura latina: de nuevo en torno al concepto de tópico
Authors: Escobar Ángel
Published: January 2024

Continuando con nuestra propuesta de reformulación del concepto de tópico literario (2000, 2006), nos ocupamos del locus a nomine. Tras remitirlo a su definición aristotélica y recordar de manera sucinta su aplicación forense y algunas de sus principales manifestaciones literarias latinas, analizamos las marcas formales que suelen caracterizar su comportamiento habitual como tópico (nomen omen, res ex nomine) y como antitópico
Jednoręki bandyta [polski oryginał]
Authors: Jankowski Wojciech
Published: January 2024

Artykuł prezentuje eksperyment myślowy dotyczący nieco dziwnej planety Losoria. Na tej planecie odpowiedzialność za pewne rodzaje przestępstw przypisywana jest w sposób całkowicie losowy. Eksperyment ma na celu wzmocnienie naszych intuicji moralnych wspierających zasadę kontroli w sporze o tzw. traf moralny. Ponadto stymuluje on refleksję nad niemoralnymi przesłankami różnicowania odpowiedzialności karnej ponoszonej za skutki działań znajdujących się poza kontrolą podmiotu. Autor wskazuje, że możliwym rozwiązaniem pewnych aporii wynikających z trafu konsekwencji jest przyjęcie sprawiedliwości naprawczej jako formy racjonalizacji kary.
EFEITOS DAS ALTERAÇÕES NO USO E OCUPAÇÃO DO SOLO NAS PERDAS DE SOLO DA BACIA DO RIO DE JANEIRO, OESTE DA BAHIA
Authors: Gomes dos Santos José Yure , Queir´ós Nascimento Rafael
Published: January 2024

O uso e ocupação do solo é um fator preponderante para a atenuação ou intensificação de processos erosivos, já que áreas que possuem uma cobertura do solo adequada apresentam menor potencial para a produção de sedimentos. Desta forma, o presente trabalho tem como objetivo realizar uma análise das perdas de solo na Bacia do Rio de Janeiro (Região Oeste da Bahia) para diferentes condições de uso e ocupação do solo, a partir da utilização da USLE em ambiente SIG. Em que foi constatado que a Bacia do Rio de Janeiro passou por uma intensa alteração no seu uso e ocupação do solo nos últimos 40 anos, com a supressão de cerca de 54% de área de vegetação nativa, o que influenciou de maneira significativa o aumento das perdas de solo na bacia. A porção oeste da bacia apresentou uma maior suscetibilidade a perdas de solo em decorrência da maior concentração da classe agricultura de sequeiro. Em contrapartida, a região leste da bacia apresentou os menores valores de perdas de solo em decorrência da predominância da vegetação nativa nesta região, evidenciando, assim, a sua eficácia em atenuar os processos erosivos.
Análise descritiva de comunicações científicas sobre pós-verdade, desinformação e infodemia em pós-graduações stricto sensu
Authors: Silva Larissa Lima da , Silva Nádia Araújo da , Rodrigues Fernando de Assis
Published: January 2024

O objetivo é realizar uma análise estatística descritiva das características dos referenciais bibliográficos ofertados em um componente curricular de pós-graduação stricto sensu que trate explicitamente de pelo menos um destes fenômenos: pós-verdade, desinformação e infodemia. Utilizou-se o repositório digital de comunicações científicas do componente curricular Mídia, saúde e pós-verdade, do Programa de Pós-Graduação em Informação e Comunicação em Saúde do Instituto de Comunicação e Informação Científica e Tecnológica em Saúde, da Fundação Oswaldo Cruz. Os procedimentos metodológicos adotados foram o estudo de caso, de natureza quantitativa, e aplicação de uma análise descritiva para categorização e detalhamento estatístico dos conteúdos das comunicações científicas. Os resultados apontaram que 18 comunicações científicas possuem relação com pelo menos um dos fenômenos mobilizados para esta pesquisa, aonde foram analisadas as características das comunicações científicas em 13 dimensões. Conclui-se que as comunicações científicas analisadas possuem referenciais científicos sobre os fenômenos de pós-verdade, de desinformação e de infodemia (este último com menor intensidade), com potencial de subsidiar as discussões sobre os fenômenos analisados.
Sharia Perspective: The Urgency of Islamic Economic, Banking and Finance (IEBF) Reform in realizing the Sustainable Development Goals (SDGs) through Knowledge Integration (IoK) Approach
Authors: Hamid Ahmad Munir
Published: January 2024

This research explores the pressing need for reform within the realm of Islamic Economic, Banking, and Finance (IEBF) from a Sharia perspective, with a particular focus on its crucial role in advancing the Sustainable Development Goals (SDGs). What sets this study apart is its innovative approach, emphasizing Knowledge Integration (IoK) as a powerful tool for achieving this reform. Through a comprehensive examination of IoK's methodological principles, including permissibility, acceptability, authenticity, and contextual adaptability, this research seeks to uncover novel ways to align IEBF practices with the principles of Sharia and the SDGs. The study emphasizes the importance of policymakers actively supporting both academic and industry efforts to incorporate IoK principles into IEBF practices. By doing so, it aims to validate the effectiveness of these principles in achieving the SDGs and fulfilling the broader maqasid. Moreover, the research highlights the potential for substantial cost savings when extracting valuable insights from the legacy writings of IoK and IEBF to guide contemporary IEBF practices. In summary, this study sheds light on the unique novelty of adopting the Knowledge Integration (IoK) approach to reform IEBF in alignment with Sharia principles and the SDGs. By doing so, it not only strengthens the scientific foundations of IEBF but also paves the way for its broader and more impactful contribution to sustainable development on a global scale.

Keywords: Integration of Knowledge, (IEBF), Sharia, and SDGs.
INTEGRATED REPORTING QUALITY DETERMINANTS: THE CASE OF BASIC MATERIALS AND INDUSTRIAL COMPANIES
Authors: Cojocaru (Bărbieru) Ana-Carolina , Mihaila Svetlana , Grosu Veronica
Published: January 2024

This study investigates the determinants of integrated reporting quality in the context of basic materials and industrial companies. The motivation stems from the need to enhance reporting quality and provide guidance to companies and academia. Specific hypotheses were formulated, including the influence of profitability, company size, age, and board size on integrated reporting quality. The research aims to offer insights into these factors' impact. The study employs a mixed-method approach involving quantitative regression analysis and qualitative content analysis. Findings reveal that profitability is not a significant determinant of integrated reporting quality, while larger companies exhibit higher-quality reports. Younger firms tend to present more elaborate reports. The study validates the role of board size in enhancing reporting quality. These results contribute to refining integrated reporting standards, enhancing transparency, and guiding strategic decisions for sustainable development.
SELECTION AND EVALUATION OF TRANSFER TECHNOLOGIES
Authors: Iatchevici Vadim
Published: January 2024

Technological development is not a process determined only by the technology itself, the characteristics of which are largely decisive. Technology must be absorbed by an initially foreign system, in which a series of process-factors manifests itself, such as: strategy, top management, organization (company), technology and environment. The results are determined by each of these factors, but especially by the interactions, the connections between them. This paper develops a methodology for selecting and evaluating technologies for transfer based on groups of evaluation criteria (strategic, financial, industry / market technology consumers, internal, technological specifications, intangible effects) with the assignment of points (prioritization) starting from the performance descriptors for each criterion. The role of performance descriptors is not only to elucidate the relative value of technologies, but also to do so as objectively as possible.
INSURANCE DEVELOPMENTS IN THE LIGHT OF DATA USE
Authors: Nadjia Madaoui
Published: January 2024

Insurance companies are increasingly utilizing large sets of data and artificial intelligence for the purpose of evaluating risks and tailoring insurance products within the framework of insurance contracts. This research seeks to examine the effects of employing extensive data in insurance contracts, particularly concerning privacy and risk. It aims to assess the extent to which existing legal regulations can safeguard policyholders from potential mistreatment resulting from the use of such methodologies. The study concludes that despite the safeguards offered by data and consumer protection laws, the unregulated and unconstrained application of data analytics and algorithms in risk evaluation could potentially harm policyholders by infringing on their privacy and leading to discrimination, thereby impinging on their rights.
PROMOTION OF NATIONAL IDENTITY AND ROMANIAN TRADITIONAL AESTHETICS THROUGH THE USE OF CONTEMPORARY ADORNMENTS
Authors: Mațcan-Lîsenco Inga
Published: January 2024

This study accentuates the importance of the contemporary jewelry in the promotion of the national Bessarabanian identity. Romanian jewelry and adornments can include traditional elements, materials and techniques for the purpose of creating a unique masterpiece, which reflect Romanian culture. The ways through which contemporary jewerly can help promote Romanian national and traditional identity include inspiring traditional motifs, exploring cultural symbols, education and awareness, collaborating with local designers, and promoting sustainability. This study highlights the vital role of contemporary jewelry in preserving and transmitting Romanian Cultural Values in Bessarabia to future generations and in creating deep connections between artists, designers and the local community. It also highlights the importance of national identity in the development of contemporary jewelry, which can contribute to the promotion of Romanian traditions and crafts in the contemporary global context.
CAUSES OF THE SPREAD OF PRIVATE TUTORING PHENOMENON A FIELD STUDY AT A CENTER IN ALGERIA
Authors: Aouissi Kamel
Published: January 2024

This research discusses the phenomenon of private tutoring, which has become a significant threat to the education system by creating academic inequalities and hindering students' equal opportunities for university enrollment. The study explores the prevalence of private tutoring at the secondary level in Ghardaia and investigates the reasons behind its widespread adoption. It also examines whether educational elements, such as teachers and the curriculum, influence the prevalence of private tutoring. Additionally, the research explores the role of families in encouraging their children to adopt this educational pattern. The descriptive-analytical methodology was employed, utilizing a questionnaire with 23 items distributed across three axes: reasons related to the student, reasons related to the teacher and curriculum, and reasons related to the family. The questionnaire was administered to a sample of individuals in Ghardaia. After analyzing the responses, the study found that the majority of the sample attributes the spread of private tutoring largely to reasons associated with the family, significant encouragement from families for their children to join private tutoring, and perceived teacher inadequacy in academic achievement. The dense curriculum was also identified as a crucial factor leading students to opt for private tutoring.
PRIMARY ASSESSMENT OF CYBERBULLYING IN THE REPUBLIC OF MOLDOVA
Authors: Alexei Arina
Published: January 2024

Cyberbullying, along with other risks associated with the use of social networks, is an emerging problem of the 21st century. The purpose of the research was the primary evaluation of the cyberbullying phenomenon and the determination of its specificity in the context of the Republic of Moldova. To achieve the purpose of the research and confirm or reject the research hypotheses, a cross-sectional study was carried out in 4 high schools in the country. The 489 students (56.2% girls and 43.8% boys), aged between 10-17 years, were recruited from these locations. The results of the study reflected a high rate of victimization among children of 53.4%, significant differences according to the gender of the victim were not identified, there was little variation between the victimization of boys (54.7%) and girls (52.4%). Social networks are the environments where students were most often victims of the phenomenon, receiving annoying or offensive messages, in 67.3% of cases from people they know, including: friends, colleagues or friends of their friends. The primary assessment of the phenomenon will allow the present study to be used as a reference for future research.
REVIEW OF THE COLLECTIVE MONOGRAPH "IMPROVING FOOD QUALITY AND SAFETY THROUGH BIOTECHNOLOGY AND FOOD ENGINEERING"
Authors: Găină Boris , Reșitca Vladislav , Vladei Natalia
Published: January 2024

The collective monograph "Improving the quality and safety of food through biotechnology and food engineering" was produced within the project code 20.80009.5107.09 "Improving the quality and safety of food through biotechnology and food engineering" within the State Program (2020-2023), Strategic Priority II "Sustainable agriculture, food security and food safety". The work is intended for specialists in the food industry, the wine industry, economic operators dealing with the production and processing of horticultural raw materials, promotion and marketing. Various aspects of increasing the biological value of food products by applying advanced technologies for the protection of biologically active compounds during manufacture and storage are analyzed. The proposed technologies also take into account possible textural and sensory changes, since the consumer is the final evaluator of food products. The collective monograph "Improving the quality and safety of food through biotechnology and food engineering" is recommended as a textbook for students of the II (Master's) and III (Doctorate) cycle of the Faculties of Food Technology and Agricultural, Forestry and Environmental Sciences.
Identification of Comparative Collagen Fibril Associated Changes in Normal and Keratoconus Corneas using Vibrational Optical Coherence Tomography and Machine Learning
Authors:   Department of Pathology and Lab Medicine, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA, Silver Frederick H
Published: January 2024

Vibrational Optical Coherence Tomography (VOCT) is a non-invasive technique that uses infrared light and audible sound to characterize tissues noninvasively.
The Rise of ESG: A Bibliometric Perspective on it’s Integration into Investment Practices
Authors: Anjali Prava Mishra Antarjyami Sahu, Pruthiranjan Dwibedi, Debasis Pahi,
Published: January 2024

This review article presents a comprehensive bibliometric analysis of 248 articles related to ESG investing from 2011 to 2023. VOSviewer and Biblioshiny, an R package, are used in the study for bibliometrics and science mapping. The terms "ESG" AND "Invest*" OR "Investor*" OR "price*" were used in the search query in scopus database. With a focus on science mapping and performance analysis, the review employs a two-phase bibliometric approach. The results shed light on publication patterns, top nations for ESG research, and the ways that impact investing, SRI, ethics, and ESG have an impact on portfolio and financial performance. The evaluation broadens the study topic for future studies and advances our understanding of the intellectual growth and traits of writers and papers in the field of ESG investing.
Gene signatures to therapeutics: Assessing the potential of ivermectin against t(4;14) multiple myeloma
Authors: Song Yang , Zhang Hao-Jun , Song Xia , Geng Jie , Li Hong-Yi , Zhang Li-Zhong , Yang Bo , Lu Xue-Chun
Published: January 2024

BACKGROUND

Multiple myeloma (MM) is a terminal differentiated B-cell tumor disease characterized by clonal proliferation of malignant plasma cells and excessive levels of monoclonal immunoglobulins in the bone marrow. The translocation, (t)(4;14), results in high-risk MM with limited treatment alternatives. Thus, there is an urgent need for identification and validation of potential treatments for this MM subtype. Microarray data and sequencing information from public databases could offer opportunities for the discovery of new diagnostic or therapeutic targets.

AIM

To elucidate the molecular basis and search for potential effective drugs of t(4;14) MM subtype by employing a comprehensive approach.

METHODS

The transcriptional signature of t(4;14) MM was sourced from the Gene Expression Omnibus. Two datasets, GSE16558 and GSE116294, which included 17 and 15 t(4;14) MM bone marrow samples, and five and four normal bone marrow samples, respectively. After the differentially expressed genes were identified, the Cytohubba tool was used to screen for hub genes. Then, the hub genes were analyzed using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis. Using the STRING database and Cytoscape, protein–protein interaction networks and core targets were identified. Potential small-molecule drugs were identified and validated using the Connectivity Map database and molecular docking analysis, respectively.

RESULTS

In this study, a total of 258 differentially expressed genes with enriched functions in cancer pathways, namely cytokine receptor interactions, nuclear factor (NF)-κB signaling pathway, lipid metabolism, atherosclerosis, and Hippo signaling pathway, were identified. Ten hub genes (cd45, vcam1, ccl3, cd56, app, cd48, btk, ccr2, cybb, and cxcl12 ) were identified. Nine drugs, including ivermectin, deforolimus, and isoliquiritigenin, were predicted by the Connectivity Map database to have potential therapeutic effects on t (4;14) MM. In molecular docking, ivermectin showed strong binding affinity to all 10 identified targets, especially cd45 and cybb . Ivermectin inhibited t(4;14) MM cell growth via the NF-κB pathway and induced MM cell apoptosis in vitro. Furthermore, ivermectin increased reactive oxygen species accumulation and altered the mitochondrial membrane potential in t(4;14) MM cells.

CONCLUSION

Collectively, the findings offer valuable molecular insights for biomarker validation and potential drug development in t(4;14) MM diagnosis and treatment, with ivermectin emerging as a potential therapeutic alternative.
Fatty acid binding protein 5 is a novel therapeutic target for hepatocellular carcinoma
Authors: Li Yan , Lee William , Zhao Zhen-Gang , Liu Yi , Cui Hao , Wang Hao-Yu
Published: January 2024

BACKGROUND

Hepatocellular carcinoma (HCC) is an aggressive subtype of liver cancer and is one of the most common cancers with high mortality worldwide. Reprogrammed lipid metabolism plays crucial roles in HCC cancer cell survival, growth, and evolution. Emerging evidence suggests the importance of fatty acid binding proteins (FABPs) in contribution to cancer progression and metastasis; however, how these FABPs are dysregulated in cancer cells, especially in HCC, and the roles of FABPs in cancer progression have not been well defined.

AIM

To understand the genetic alterations and expression of FABPs and their associated cancer hallmarks and oncogenes in contributing to cancer malignancies.

METHODS

We used The Cancer Genome Atlas datasets of pan cancer and liver hepatocellular carcinoma (LIHC) as well as patient cohorts with other cancer types in this study. We investigated genetic alterations of FABPs in various cancer types. mRNA expression was used to determine if FABPs are abnormally expressed in tumor tissues compared to non-tumor controls and to investigate whether their expression correlates with patient clinical outcome, enriched cancer hallmarks and oncogenes previously reported for patients with HCC. We determined the protein levels of FABP5 and its correlated genes in two HCC cell lines and assessed the potential of FABP5 inhibition in treating HCC cells.

RESULTS

We discovered that a gene cluster including five FABP family members (FABP4, FABP5, FABP8, FABP9 and FABP12 ) is frequently co-amplified in cancer. Amplification, in fact, is the most common genetic alteration for FABPs, leading to overexpression of FABPs. FABP5 showed the greatest differential mRNA expression comparing tumor with non-tumor tissues. High FABP5 expression correlates well with worse patient outcomes (P < 0.05). FABP5 expression highly correlates with enrichment of G2M checkpoint (r = 0.33, P = 1.1e-10), TP53 signaling pathway (r = 0.22, P = 1.7e-5) and many genes in the gene sets such as CDK1 (r = 0.56, P = 0), CDK4 (r = 0.49, P = 0), and TP53 (r = 0.22, P = 1.6e-5). Furthermore, FABP5 also correlates well with two co-expressed oncogenes PLK1 and BIRC5 in pan cancer especially in LIHC patients (r = 0.58, P = 0; r = 0.58, P = 0; respectively). FABP5high Huh7 cells also expressed higher protein levels of p53, BIRC5, CDK1, CDK2, and CDK4 than FABP5low HepG2 cells. FABP5 inhibition more potently inhibited the tumor cell growth in Huh7 cells than in HepG2 cells.

CONCLUSION

We discovered that FABP5 gene is frequently amplified in cancer, especially in HCC, leading to its significant elevated expression in HCC. Its high expression correlates well with worse patient outcome, enriched cancer hallmarks and oncogenes in HCC. FABP5 inhibition impaired the cell viability of FABP5high Huh7 cells. All these support that FABP5 is a novel therapeutic target for treating FABP5high HCC.
Radiotherapy for hyoid bone metastasis from lung adenocarcinoma: A case report
Authors: Hsu Jonathan , Hribar Kambridge , Poen Joseph
Published: January 2024

BACKGROUND

Metastasis to the hyoid bone is an exceptionally rare occurrence, with documented cases limited to breast, liver, colon, skin, lung, and prostate cancers. This report highlights an unusual case involving the metastasis of lung adenocarcinoma to the hyoid bone, accompanied by a distinctive headache. Previous documentation involved surgical resection of the hyoid mass. We present a case displaying the benefits of palliative radiotherapy.

CASE SUMMARY

A 72-year-old non-smoking, non-alcoholic woman, initially under investigation for a year-long elevation in absolute lymphocyte count, presented with a month-long history of intermittent throat pain. Despite negative findings in gastroenterological and otolaryngologic examinations, a contrast-enhanced chest computed tomography scan revealed a mediastinal mass and questionable soft tissue thickening in her left anterolateral neck. Subsequent imaging and biopsies confirmed the presence of lung adenocarcinoma metastasis to the hyoid bone. The patient was treated with platinum-based chemo-immunotherapy along with pembrolizumab. Ultimately, the lung cancer was unresponsive. Our patient opted for palliative radiation therapy instead of surgical resection to address her throat pain. As a result, her throat pain was alleviated, and it also incidentally resolved her chronic headaches. This is the second documented case of lung adenocarcinoma metastasizing to the hyoid bone.

CONCLUSION

Palliative radiotherapy may add to the quality of life in symptomatic patients with cancer metastatic to the hyoid bone.
Scinderin promotes glioma cell migration and invasion via remodeling actin cytoskeleton
Authors: Lin Xin , Zhao Zhao , Sun Shu-Peng , Liu Wei
Published: January 2024

BACKGROUND

Glioma is one of the most common intracranial tumors, characterized by invasive growth and poor prognosis. Actin cytoskeletal rearrangement is an essential event of tumor cell migration. The actin dynamics-related protein scinderin (SCIN) has been reported to be closely related to tumor cell migration and invasion in several cancers.

AIM

To investigate the role and mechanism of SCIN in glioma.

METHODS

The expression and clinical significance of SCIN in glioma were analyzed based on public databases. SCIN expression was examined using real-time quantitative polymerase chain reaction and Western blotting. Gene silencing was performed using short hairpin RNA transfection. Cell viability, migration, and invasion were assessed using cell counting kit 8 assay, wound healing, and Matrigel invasion assays, respectively. F-actin cytoskeleton organization was assessed using F-actin staining.

RESULTS

SCIN expression was significantly elevated in glioma, and high levels of SCIN were associated with advanced tumor grade and wild-type isocitrate dehydrogenase. Furthermore, SCIN-deficient cells exhibited decreased proliferation, migration, and invasion in U87 and U251 cells. Moreover, knockdown of SCIN inhibited the RhoA/focal adhesion kinase (FAK) signaling to promote F-actin depolymerization in U87 and U251 cells.

CONCLUSION

SCIN modulates the actin cytoskeleton via activating RhoA/FAK signaling, thereby promoting the migration and invasion of glioma cells. This study identified the cancer-promoting effect of SCIN and provided a potential therapeutic target for the treatment of glioma.
Studiul compoziției antocienilor monomerici în vinurile roşii din soiurile de struguri autohtone şi de selecţie nouă prin metoda HPLC
Authors: Skorbanova Elena , Taran Nicolae , Ponomariova Irina , Degteari Natalia , Rinda Parascovia , Efremov Egor
Published: January 2024

The data on the composition of monomeric anthocyanins, which determine the color of dry red wines from the new selection grape variety Codrinschi and local grape varieties: Copceac, Feteasca neagra, Negru de Causeni, have been obtained by the modern instrumental method of analysis – HPLC. The quantities of these compounds, characteristic for each variety, have been determined.
Moisture binding ratio forms in formulations of minced meat semifinished products modified using protein-carbohydrate composition
Authors: Absalimova M. A. , Taeva A. М. , Rskeldiev B. A. , Peregonchaya O. V. , Glotova I. A.
Published: January 2024

Popular products in the consumer market of the Republic of Kazakhstan are meat semi-finished products. At the same time, according to trends in consumer demand, chopped semifinished products retain priority positions. An effective approach to replace part of meat raw materials in the formulations of chopped semi-finished products is the development of functional analogs of meat raw materials and products on its basis using vegetable raw material sources. An important task is to ensure the hydration characteristics of the food system, are not inferior to the basic recipes of meat semi-finished products of traditional composition. The work aims to investigate the influence of protein-carbohydrate composition (PCC) from soya okara, chickpea flour, and whey protein concentrate WPC-80 on moisture capacity and the ratio of forms of moisture binding in meat minced semi-finished products with the use of actual for the Republic of Kazakhstan types of meat raw materials - beef, mutton, poultry meat. The results allow for comparing temperature intervals of stages of thermal transformation and the quantity of water removed at separate stages of dehydration from the phase of investigated samples. The first stage, corresponding to the removal of physico-mechanically bound moisture, occurs in the temperature range from room temperature to 32-34°C for all samples. The amount of such water in the sample phase does not exceed 2 %. Osmotically bound moisture removed at the second stage is the basis of all water saturating the samples. Its quantity is maximum in the composition of samples № 2 and № 3. At the same time, the widest temperature range of the second stage of dehydration also characterizes samples № 2 and 3: 94 °C and 103 °C, respectively. Removal of adsorption and chemically bound moisture at the third stage of thermal transformation occurs at high temperatures and may be accompanied by thermolysis of sample components. The share of moisture removed at this stage of the process from the phase of the sample does not exceed 16.3 %, which is maximum for PCC and minimum for sample № 4 (13.7 %). The results indicate a higher hydration level of the samples prepared according to the modified formulations with PCC, compared to the control sample. This is due to the influence of protein-carbohydrate complexes containing polysaccharides, simple sugars, and disaccharides on the degree of water molecules binding.
Implementation of digital gis models in desktop applications developed on the basis of the «QT» framework
Authors: Ibraimov Zh. B. , Amirov A. Zh.
Published: January 2024

This article explores the implementation of digital geoinformation systems (GIS) models in desktop applications using the Qt framework. This highlights the importance of GIS technologies in various fields and the need for powerful desktop applications capable of efficiently processing spatial data. Integration of GIS models into Qt-based applications provides a number of advantages, such as efficient data management, spatial analysis and user-friendly interfaces. The article highlights the cross-platform compatibility of the Qt framework, which allows you to deploy GIS-enabled applications on multiple operating systems. In conclusion, it should be noted that the introduction of digital GIS models into desktop applications developed using the Qt framework provides significant benefits to both developers and users. This allows users to access, analyze and visualize geospatial data, thereby improving decision-making processes. The combination of GIS and Qt capabilities allows developers to create reliable and user-friendly applications to meet the growing demand for spatial data management and analysis tools. The list of sources used includes links to the official Qt and Esri websites, as well as relevant publications related to integration, GIS and noise mapping using ArcGIS.
Paticularities of radiation defect formation in ceramic barium cerate
Authors: Khromushin I. V. , Aksenova T. I. , Tuseev T. , Munasbayeva K. K. , Bolatbekuly A.
Published: January 2024

The results of the investigations are presented on the effect of irradiation with electrons, ions of inert gases (Ne, Ar, Kr) and oxygen on the structure and properties of Nd-doped barium cerate by the methods of X-ray diffraction analysis, scanning electron and atomic force microscopy, thermal desorption spectroscopy. It is shown that the low-energy irradiation with Ne and Ar ions stimulates the blistering processes on the surface, whereas the high energy ion irradiation by Ne, Ar, Kr ions the cerate surface undergoes the following stages of the spherulite growth - nucleation, growth (view of cauliflower), formation of spherulitic crust, correspondingly. The similar structures were not observed in the case of irradiation with high-energy oxygen ions. It is noticed that the irradiation of cerates with electrons leads to the formation of nano-sized acicular structures on the surface. The radiation of lowenergy ions of inert gases led to the conversion of most of the neodymium into a tetravalent state, as has been shown, accompanied by an increase in oxygen release and a decrease in water compared to non-irradiated cerate, as well as the independence of the amount of gases from the type of ions. Based on the data on thermal desorption of water and oxygen molecules from the irradiated barium cerate it was assumed that the irradiation stimulates the oxidation to Nd4+.
Analysis of metallurgical products for antimony content
Authors: Aubakirova R. A. , Mukazhanova J. B. , Kabdulkarimova K. K. , Afanasenkova I. V. , Sanyazovа S. K.
Published: January 2024

Antimony is widely used in modern science and technology. Currently, the most important consumer of high-purity antimony is the semiconductor industry.

The article presents the results of the analysis of metallurgical samples for the content of antimony, which belongs to the group of harmful impurities.

Traditionally, the decomposition of metallurgical samples is carried out by acid dissolution of the sample, alkali fusion or sintering. The least labor-intensive method is acid dissolution. However, this method has a number of significant disadvantages: incomplete opening, loss of antimony due to the hydrolysis of its salts, and the interfering influence of accompanying elements that also pass into solution during acidic dissolution of the sample. The most reliable results in the photometric determination of antimony content can be obtained by sintering a sample, accompanied by the separation of interfering elements by their precipitation in the form of carbonates and the transfer of antimony into a form that is not subject to hydrolysis (MexSbyOz antimonates). However, the specific conditions for the sintering process of antimony-containing metallurgical samples are not described in the literature.

The work proposes a method for the decomposition of metallurgical samples, which consists of sintering the samples under study with Na2CO3 + ZnO. The phase composition of the presented samples has been established. A calibration characteristic for the photometric determination of antimony content in the concentration range from 1•10-3 to 1•10-2 mg/ml at a wavelength of 425 nm was constructed.
Properties and applications of keratin from the waste of animal-farming (review article)
Authors: Sultan M. D. , Ospanova Zh. B. , Musabekov K. B. , Kenzhebaev T. E. , Takhistov P.
Published: January 2024

The study aims to provide a modern overview of the properties of keratin-containing raw materials from animal waste among the research scientists over the past decades and to show the important role of keratin in science. This review examines the composition and types of keratin, the scope of application, the functions of keratin, distribution in animal husbandry and fish farming, as well as in mammals. It is important to note that keratin is widely used in biomedicine, tissue engineering, bioplastics, textiles, biocomposites in construction and building materials. This article reveals the physical and chemical properties and advantages of keratin, such as biodegradability, mechanical abilities, resistance to temperature conditions and thermal conductivity. Keratin can be synthesized from different raw materials, such as wool, hair, bird feathers, using different methods. The extraction method can be of several types: oxidative and reducing, as well as extraction by steam explosion. Extracted keratin has generated increased interest for its study and research for medical purposes, or rather the first innovative discoveries were made among cosmetics, coatings for medicines and fibers. Keratin extracted from animal waste represents a promising active biomolecule for biological and biomaterial applications. The exceptional properties that keratin transmits by virtue of its nature open up the possibility of replacing synthetic materials with biomaterials more compatible with humans and biodegradable, which can improve the overall economy of the closed cycle of agro-industrial complexes.
Problems of ensuring the safety of automated systems
Authors: Alimzhanova Z. M. , Baiuzakova A. K.
Published: January 2024

The article discusses the issue of "automated system and its security", which is actively used today in the framework of Information Systems. In what areas are automated systems used, the problem of strength in terms of safety and analysis of the state of protection is solved. Automated systems are of great importance in the modern world, as they greatly simplify and speed up the implementation of various daily tasks, data and process management. The relevance of automated systems depends on such factors as efficiency and productivity, improving data quality, scaling, and developing analytics. However, it is important to understand that with the growth of automation, the risk in the field of data security and privacy will also increase.

Automated systems become targets of cyber attacks and can threaten the confidentiality, integrity and availability of data. Thus, the safety of automated systems remains one of the main issues. That is, the lack of appropriate security measures can lead to data loss, privacy violations and financial losses. Therefore, organizations need to actively invest in the protection and control of their nuclear power plants by implementing access control, encryption, incident detection mechanisms, and training employees in safety regulations.
Development of information technology for secure file storage based on hybrid cryptography methods
Authors: Manap A. T. , Abitova G. A.
Published: January 2024

This article explores the development of information technology for secure file storage based on hybrid cryptography methods. It highlights the importance of secure file storage in the digital age and introduces hybrid cryptography as a solution for enhanced data security. The purpose of the article is to provide a comprehensive understanding of the benefits and advancements in hybrid cryptography for secure file storage.

The article discusses the differences between symmetric and asymmetric encryption algorithms and introduces hybrid cryptography as a combination of both. It delves into the advantages of hybrid cryptography, emphasizing its ability to provide robust security and efficient data protection. The use of hybrid cryptography in encryption at rest and encryption in transit is examined, highlighting its role in securing stored data and ensuring secure data transmission.

Moreover, the article explores the authentication, integrity, and reliability features provided by hybrid cryptography. It discusses the importance of key management and its impact on secure file storage.
Ocratoxina A em amostras de uva passa comercializadas em São Paulo, Brasil
Authors: Almeida Adriana Palma de , Alaburda Janete , Ruvieri Valter , Sabino Myrna
Published: January 2024

O presente estudo teve como objetivo avaliar uma metodologia para análise de ocratoxina A (OTA) em amostras de uva passa comercializadas em São Paulo, Brasil. A OTA foi extraída com metanol: água(80:20, v/v) e diluída com solução tampão fosfato, utilizando-se coluna de imunoafinidade para purificação da amostra. A OTA foi separada e quantificada por meio de CLAE com detector de fluorescência. Os limites de detecção e de quantificação estabelecidos foram respectivamente de 0,24 e 0,80 ng/g. Os valores de recuperação foram 81,6; 80,4 e 81,9% e os coeficientes de variação foram 6,0; 4,3 e 6,1 % respectivamente para os níveis de 2,0; 5,0 e 10,0 ng/g. De um total de vinte amostras de uvas passas pretas, 10 (50 %) continham OTA na faixa de concentrações de 1,3 a 39,1 ng/g. Todas as vinte e duas amostras de uvas passas brancas não apresentaram contaminação por OTA.
Efeito da adição de Streptococcus thermophilus como cultura adjunta na maturação e caracterização físico-química e sensorial de queijo Prato
Authors: Silva Claudia R. B. , Nabuco Aline Cristina , Moretti Bruna R. , Penna Ana Lúcia Barretto
Published: January 2024

As culturas lácteas desempenham funções fundamentais na maturação de queijos, tais como produção de ácido lático e de compostos aromatizantes voláteis. Neste trabalho, o objetivo foi avaliar a ação de Streptococcus thermophilus como cultura adjunta, nos índices de proteólise e nas características físico-químicas e sensoriais do queijo Prato. As amostras de queijo foram preparadas conforme dois tratamentos: (1) utilização de cultura mesofílica - Lactococcus lactis ssp lactis e Lactococcus lactis ssp cremoris (tratamento 1) e (2) cultura mesofílica acrescida de Streptococcus thermophilus (tratamento 2). Durante a maturação dos queijos, foram realizadas análises físico-químicas (extrato seco total, gordura, gordura no extrato seco - GES, cinzas, nitrogênio, proteína total, índice de extensão da maturação - IEM, índice de profundidade da maturação - IPM, tirosina, triptofano e atividade de água) e sensoriais (odor, aroma, doce, ácido, salgado, amargo, adstringente, picante, elasticidade, firmeza, friabilidade, adesividade, solubilidade e umidade). O queijo fabricado conforme o tratamento 1 foi o mais proteolítico, resultando em características sensoriais mais acentuadas de acidez, amargor, sabor picante, elasticidade e solubilidade, comparado ao produto preparado com adição de Streptococcus thermophilus.
Avaliação dos exames laboratoriais para o diagnóstico das meningites infecciosas no estado de Sergipe, durante o período de 1997 a 2003
Authors: Barbosa Junior Antonio M. , Mélo Dângelly L. F. M. de , Santos Patrícia O. , Travália Maria de Fátima , Trindade Rita de C.
Published: January 2024

As meningites infecciosas continuam a ocorrer no país com alta incidência e elevados índices de mortalidade, apesar da existência de programas de prevenção da doença e dos avanços na tecnologia empregada na detecção dos microrganismos envolvidos. O exame laboratorial do líquido céfalorraquidiano (LCR) é a base para efetuar o diagnóstico e para introdução de tratamento eficaz ao paciente. Na rotina laboratorial, são utilizados para o diagnóstico: exame microscópico, cultura e pesquisa de antígeno. Visando conhecer a eficiência e a capacidade de resposta, bem como para efetuar a correlação das referidas técnicas laboratoriais com os dados clínicos, este trabalho investigou 510 fichas de registros de pacientes com suspeita de meningite, atendidos pelo Serviço Único de Saúde, que deram entrada no período de 1997 a 2003, no Laboratório Central de Saúde Pública no estado de Sergipe, no Instituto Parreiras Horta. Foi realizada a análise de freqüências absolutas dos testes utilizados no diagnóstico das meningites infecciosas. Os dados mostram uma diminuição, nos últimos anos, da porcentagem de confirmação de diagnóstico de meningite por meio de cultura, fato que pode ser observado em pesquisas realizadas em outros laboratórios do Brasil. Em contrapartida, verifica-se um aumento expressivo no número de paciente com meningites confirmado por meio de bacterioscopia, utilizando-se a coloração de Gram. Os resultados apresentados confirmam a importância do diagnóstico rápido e preciso que ofereça vantagens clínicas significativas para o emprego da terapia antimicrobiana adequada e acompanhamento da evolução da doença.