bluuebunny/crossref_metadata_2025 huggingface dataset:
Stereoselective Asymmetric Syntheses of Molecules with a 4,5-Dihydro-1H-[1,2,4]-Triazoline Core Possessing an Acetylated Carbohydrate Appendage: Crystal Structure, Spectroscopy, and Pharmacology
Authors: Al Maqbali Anwaar S. , Al Rasbi Nawal K. , Zoghaib Wajdi M. , Sivakumar Nallusamy , Robertson Craig C. , Shongwe Musa S. , Grzegorzek Norbert , Abdel-Jalil Raid J.
Published: June 2024

A new series of chiral 4,5-dihydro-1H-[1,2,4]-triazoline molecules, featuring a β-ᴅ-glucopyranoside appendage, were synthesized via a 1,3-dipolar cycloaddition reaction between various hydrazonyl chlorides and carbohydrate Schiff bases. The isolated enantiopure triazolines (8a–j) were identified through high-resolution mass spectrometry (HRMS) and vibrational spectroscopy. Subsequently, their solution structures were elucidated through NMR spectroscopic techniques. Single-crystal X-ray analysis of derivative 8b provided definitive evidence for the 3-D structure of this compound and revealed important intermolecular forces in the crystal lattice. Moreover, it confirmed the (S)-configuration at the newly generated stereo-center. Selected target compounds were investigated for anti-tumor activity in 60 cancer cell lines, with derivative 8c showing the highest potency, particularly against leukemia. Additionally, substituent-dependent anti-fungal and anti-bacterial behavior was observed.
Characterization of the Components and Metabolites of Achyranthes Bidentata in the Plasma and Brain Tissue of Rats Based on Ultrahigh Performance Liquid Chromatography–High-Resolution Mass Spectrometry (UHPLC–HR-MS)
Authors: Wu Mengting , Yang Peilin , Wang Jianying , Yang Ruoyan , Chen Yingyuan , Liu Kun , Yuan Ying , Zhang Lei
Published: June 2024

Background: Achyranthes bidentata (AR) is a traditional Chinese herb used for the treatment of hypertension and cerebral ischemia, but its pharmacological effects are not known. Aim of study: We aimed to detect and accurately identify the components and metabolites of AR in the plasma and brain tissue of Sprague Dawley rats. Methods: We employed ultrahigh performance liquid chromatography–high-resolution mass spectrometry (UHPLC–HR-MS) to detect AR components in the plasma and brain tissue of rats. The absorption and metabolites in the plasma and brain tissue of normal control rats and rats that underwent middle cerebral artery occlusion (MCAO) were characterized and compared. Results: A total of 281 compounds, including alkaloids, flavonoids, terpenoids, phenylpropanes, sugars and glycosides, steroids, triterpenes, amino acids, and peptides, was identified in samples of Achyranthes bidentata (TCM-AR). Four types of absorbable prototype components and 48 kinds of metabolites were identified in rats in the normal control plasma group which were given AR (AR plasma group), and five kinds of metabolites were identified in rats of the normal control brain tissue group which were given AR (AR brain group). Three absorbed prototype components and 13 metabolites were identified in the plasma of rats which underwent MCAO and were given AR (MCAO + AR plasma group). Six absorbed prototype components and two metabolites were identified in the brain tissue of rats who underwent MCAO and were administered AR (MCAO + AR brain group). These results showed that, after the oral administration of AR, the number of identified components in plasma was more than that in brain tissue. The number of prototype components in the AR plasma group was higher than that in the MCAO + AR plasma group, which may indicate that metabolite absorption in rats undergoing MCAO was worse. The number of prototype components in the MCAO + AR brain group was higher than that in the AR brain group, indicating that the blood–brain barrier was destroyed after MCAO, resulting in more compounds entering brain tissue. Conclusions: UHPLC–HR-MS was used to rapidly analyze the components and metabolites of AR in the blood and brain of rats under normal and pathologic conditions, and to comprehensively characterize the components of TCM-AR. We also analyzed and compared the absorbable components and metabolites of normal rats under cerebral ischemia-reperfusion injury to explore the potential mechanism of action. This method could be applied to various Chinese herbs and disease models, which could promote TCM modernization.
Micron-Sized Thiol-Functional Polysilsesquioxane Microspheres with Open and Interconnected Macropores: Effects of the System Composition on the Porous Structure and Particle Size of the Microspheres
Authors: Han Lu , Nie Zhenyu , Gao Rongsheng , Kan Chengyou
Published: June 2024

Control of the porous structure and particle size is essential for improving the properties of polysilsesquioxane (PSQ) microspheres. Herein, using the strategy combining inverse suspension polymerization, two-step sol–gel- and polymerization-induced phase separation processes, micron-sized thiol-containing macroporous PSQ (TMPSQ) microspheres with controllable morphologies, adjustable particle diameters (4.9–17.3 μm), and pore sizes (40–3774 nm) were prepared. The morphology and size of the TMPSQ microspheres were characterized by SEM. The mercury intrusion method was employed to analyze the porous structure of the microspheres. The effects of the composition of the sol–gel disperse phase, the mass ratio of the sol–gel disperse phase to the oil continuous phase (WRW/O), and the Span 80 mass content in the oil continuous phase on the morphology, particle diameter and pore size of the TMPSQ microspheres were investigated. Results indicated that the composition of the sol–gel disperse phase determines the morphology and porous structure of the microspheres, and WRW/O and Span 80 content have remarkable impacts on the morphology and particle size of the microspheres. This study is beneficial to the design and fabrication of functional PSQ microspheres with desired properties and promising application prospects.
Selected Psychosocial Factors, Nutritional Behavior, and the Analysis of Concentrations of Selected Vitamins in Patients with Cardiovascular Diseases
Authors: Główka Anna Krystyna , Kowalówka Magdalena , Burchardt Paweł , Komosa Anna , Kruszyna Łukasz , Andrusiewicz Mirosław , Przysławski Juliusz , Karaźniewicz-Łada Marta
Published: June 2024

Cardiovascular diseases (CVD) are the leading cause of death worldwide, influenced by the interaction of factors, including age, sex, genetic conditions, overweight/obesity, hypertension, an abnormal lipid profile, vitamin deficiencies, diabetes, and psychological factors. This study aimed to assess the relationships between psychosocial and nutritional factors in a group of 61 patients with CVD (i.e., atherosclerosis, hypertension, ischemic heart disease, and myocardial infarction) and their possible impact on the course of the disease. The plasma concentrations of vitamins A, E, D, and β-carotene were determined using validated HPLC-MS/MS, while the lipid profile was analyzed enzymatically. Psychosocial factors and nutritional behaviors were assessed using author-designed questionnaires. Over 50% of patients had 25-OH-D3 and retinol deficiencies, while >85% of patients exhibited significant deficiencies in α-tocopherol and β-carotene. The lipid profile showed no specific relationship with any particular CVD. Dietary behavior minimally impacted biochemical parameters except for higher β-carotene concentrations in the group with higher fruit and vegetable intake. The negative impact of the CVD on selected parameters of quality of life was noticed. To increase the effectiveness of the prevention and treatment of CVD, the need for interdisciplinary cooperation observed between doctors, psychologists, and specialists in human nutrition seems to be justified.
Mixture of Rhodiola rosea and Nelumbo nucifera Extracts Ameliorates Sleep Quality of Adults with Sleep Disturbance
Authors: Kim Yunna , Lee Won Kyung , Jeong Hyein , Choi Hyuck Jai , Lee Mi-Kyung , Cho Seung-Hun
Published: June 2024

Chronic sleep disturbance affects daily functioning, leading to decreased concentration, fatigue, and higher healthcare costs. Traditional insomnia medications are often associated with adverse side effects. This study investigated the efficacy of a novel compound derived from Rhodiola rosea and Nelumbo nucifera extracts (named RNE) in improving sleep quality with fewer side effects. The study included individuals between the ages of 20 and 65 with subthreshold insomnia and evaluated the effects of RNE on sleep, fatigue, and quality of life. Participants took 750 mg of RNE daily at bed-time for two weeks. The study used the Insomnia Severity Index (ISI), the Pittsburgh Sleep Quality Index (PSQI), a sleep diary, the Fatigue Severity Scale (FSS), and the Short Form 36 Health Survey (SF-36) for assessments. Of the 20 participants, 13 completed the study and showed significant improvements in sleep quality. The results showed improvements in ISI and PSQI scores, a 57% reduction in wake-time after sleep onset, and improved sleep efficiency. Although FSS scores remained unchanged, significant improvements were seen in SF-36 physical and mental health scores. The results suggest that RNE is an effective, low-risk option for sleep disturbance, significantly improving sleep quality and overall wellbeing without significant side effects.
Hawthorn Vinegar in Health with a Focus on Immune Responses
Authors: Seyidoglu Nilay , Karakçı Deniz , Bakır Buket , Yıkmış Seydi
Published: June 2024

Background: The hawthorn fruit is an interesting medicinal plant that has several biological features, especially related to anti-inflammatory, antioxidant and immune-modulating actions, and boosting general health. In this study, we aimed to clarify the immunological effects of hawthorn vinegar on immunity and general health. We also focused on three different production processes to improve the antioxidant activity of hawthorn vinegar (2) Methods: In the study, besides the traditional production of hawthorn vinegar (N), thermal pasteurization (P) and ultrasound (U) techniques were applied to vinegars. A total of 56 female adult Wistar albino rats were randomly allocated into seven groups; Control, N0.5 (regular vinegar; 0.5 mL/kgbw), N1 (regular vinegar; 1 mL/kgbw), P0.5 (pasteurized vinegar; 0.5 mL/kgbw), P1 (pasteurized vinegar; 1 mL/kgbw), U0.5 (ultrasound treated vinegar; 0.5 mL/kgbw), and U1 (ultrasound treated vinegar; 1 mL/kgbw). Vinegars were administered by oral gavage daily. The average weight gains, body mass index, and blood hematological parameters were measured, and the Neutrophil Lymphocyte ratio was calculated. The plasma IL-1β and TNF-α values, and MDA, IL-1β and TNF-α values of intestinal tissue, were determined. Also, the streptavidin–biotin–peroxidase complex method was applied to determine the expressions of TNF-α and IL-1β in duodenum. (3) Results: There was a decreasing tendency in the average weight gains in all vinegar groups compared to the control group. In addition, there was an increase in NL ratio in all vinegar groups, although not significant. There were no statistical differences among all vinegar groups, although decreases were observed in plasma IL-1β. Also, the plasma TNF-α values showed slight increases in high-dose-of-vinegar groups (N1, P1 and U1), although not significant. In addition, the intestinal tissue IL-1β value tended to increase in groups N0.5, N1 and P0.5, while it tended to decrease in P1, U0.5 and U1. On the other hand, there were slight increases in the TNF-α values of intestinal tissue in all groups compared to control, although these were not significant. Furthermore, the intensive expressions of TNF-α and IL-1β were determined in groups U0.5 and U1. (4) Conclusions: The results suggest that either high doses or ultrasound applications of hawthorn vinegar have positive effects on intestinal health, boosting immunity and general health.
Evidence and Perspectives for Choline Supplementation during Parenteral Nutrition—A Narrative Review
Authors: Bernhard Wolfgang , Böckmann Katrin A. , Minarski Michaela , Wiechers Cornelia , Busch Annegret , Bach Daniela , Poets Christian F. , Franz Axel R.
Published: June 2024

Choline is an essential nutrient, with high requirements during fetal and postnatal growth. Tissue concentrations of total choline are tightly regulated, requiring an increase in its pool size proportional to growth. Phosphatidylcholine and sphingomyelin, containing a choline headgroup, are constitutive membrane phospholipids, accounting for >85% of total choline, indicating that choline requirements are particularly high during growth. Daily phosphatidylcholine secretion via bile for lipid digestion and very low-density lipoproteins for plasma transport of arachidonic and docosahexaenoic acid to other organs exceed 50% of its hepatic pool. Moreover, phosphatidylcholine is required for converting pro-apoptotic ceramides to sphingomyelin, while choline is the source of betaine as a methyl donor for creatine synthesis, DNA methylation/repair and kidney function. Interrupted choline supply, as during current total parenteral nutrition (TPN), causes a rapid drop in plasma choline concentration and accumulating deficit. The American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) defined choline as critical to all infants requiring TPN, claiming its inclusion in parenteral feeding regimes. We performed a systematic literature search in Pubmed with the terms “choline” and “parenteral nutrition”, resulting in 47 relevant publications. Their results, together with cross-references, are discussed. While studies on parenteral choline administration in neonates and older children are lacking, preclinical and observational studies, as well as small randomized controlled trials in adults, suggest choline deficiency as a major contributor to acute and chronic TPN-associated liver disease, and the safety and efficacy of parenteral choline administration for its prevention. Hence, we call for choline formulations suitable to be added to TPN solutions and clinical trials to study their efficacy, particularly in growing children including preterm infants.
Phytochemical Study of the Anthelminthic Potential of Guadeloupean Plant Biodiversity
Authors: Cabald Tressy , Marie-Magdeleine Carine , Philibert Lucien , Caradeuc Cédric , Bertho Gildas , Giraud Nicolas , Cebrián-Torrejón Gerardo , Sylvestre Muriel
Published: June 2024

Gastrointestinal parasitism is a major health and welfare problem in ruminants. Synthetic chemical anthelmintic drugs have led to the emergence of resistance in gastrointestinal strongyles, inducing the search for alternatives to control the infections that affect ruminants. The objective of this work was to evaluate the anthelmintic potential of plant extracts against Haemonchus contortus Rudolphi. Three plants of the Guadeloupean biodiversity, Momordica charantia L., Carica papaya L. and Sargassum spp., were selected based on their high polyphenolic content and natural abundance. The phytochemistry of plants was explored, a biological assay against the parasite H. contortus was carried out, and several hypotheses about the way of action were proposed by an innovative electrochemical screening method.
Tailored Treatment Strategies in First Line Therapy for Ovarian Cancer Patients: A Critical Review of the Literature
Authors: Luvero Daniela , Angioli Roberto , Celoro Federica , Plotti Francesco , Terranova Corrado , Guzzo Federica , Cundari Gianna Barbara , Liparulo Federico , Verdone Camilla , Montera Roberto
Published: June 2024

Background: Ovarian cancer (OC) is a significant cause of cancer-related mortality in women globally, with a five-year survival rate of approximately 49%. Standard therapy involves cytoreductive surgery followed by chemotherapy. Its poor prognosis has driven interest in alternative therapies such as targeted molecular agents like bevacizumab and poly (ADP-ribose) polymerase inhibitors (PARPi). Materials and Methods: This review systematically searched PubMed from January 2018 to December 2023 for studies on PARPi in OC. Emphasis was on identifying relevant Phase III trials, extracting data on study design, patient demographics, and outcomes. Special focus was on assessing PARPi efficacy, safety, impact on quality of life, and ongoing trials, including those on Clinicaltrials.gov. Results: The efficacy of PARPi in first-line therapy for OC has been extensively studied. Trials like SOLO-1, PRIMA, and ATHENA-MONO have demonstrated significant improvements in progression-free survival (PFS) and overall survival (OS), particularly in patients with BRCA mutations. Additionally, the combination of PARPi with other agents like bevacizumab has shown promising results in extending PFS. However, PARPi treatment is associated with various adverse effects, including hematologic toxicities like anemia, thrombocytopenia, and neutropenia. While most adverse events are manageable, some patients may require dose adjustments or discontinuation of treatment. Importantly, PARPi maintenance therapy has not adversely affected health-related quality of life (HRQoL), with studies reporting similar HRQoL scores between PARPi-treated and placebo-treated patients. Conclusions: PARPi offer effective treatment with manageable side effects, suitable even for medically fragile patients. Individualized dosing can optimize benefits while minimizing adverse events. Exploring diverse treatment approaches, particularly in patients with limited life expectancy or high disease burden, could improve outcomes. Ongoing research is investigating alternative therapies and combinations to broaden treatment options. Combining bevacizumab with PARPi may be justified for first-line and recurrent maintenance therapy. Regardless of mutational status, PARPi should be considered for maintenance therapy in newly diagnosed advanced OC. Platinum sensitivity remains crucial for treatment decisions and predicting survival outcomes.
Novel Anti-Enterovirus A71 Compounds Discovered by Repositioning Antivirals from the Open-Source MMV Pandemic Response Box
Authors: Lochaiyakun Nattinee , Srimanote Potjanee , Khantisitthiporn Onruedee , Thanongsaksrikul Jeeraphong
Published: June 2024

The open-source drug library, namely, MMV Pandemic Response Box, contains 153 antiviral agents, a chemically and pharmacologically diverse mixture of early-stage, emerging anti-infective scaffolds, and mature compounds currently undergoing clinical development. Hence, the Pandemic Response Box might contain compounds that bind and interfere with target molecules or cellular pathways that are conserved or shared among the closely related viruses with enterovirus A71 (EV-A71). This study aimed to screen antiviral agents included in the Pandemic Response Box for repurposing to anti-EV-A71 activity and investigate the inhibitory effects of the compounds on viral replication. The compounds’ cytotoxicity and ability to rescue infected cells were determined by % cell survival using an SRB assay. The hit compounds were verified for anti-EV-A71 activity by virus reduction assays for viral RNA copy numbers, viral protein synthesis, and mature particle production using qRT-PCR, Western blot analysis, and CCID50 assay, respectively. It was found that some of the hit compounds could reduce EV-A71 genome replication and protein synthesis. D-D7 (2-pyridone-containing human rhinovirus 3C protease inhibitor) exhibited the highest anti-EV-A71 activity. Even though D-D7 has been originally indicated as a polyprotein processing inhibitor of human rhinovirus 3C protease, it could be repurposed as an anti-EV-A71 agent.
Prospect of Gold Nanoparticles in Pancreatic Cancer
Authors: Yin Tianyi , Han Jingrun , Cui Yuying , Shang Dong , Xiang Hong
Published: June 2024

Pancreatic cancer (PC) is characterized by its notably poor prognosis and high mortality rate, underscoring the critical need for advancements in its diagnosis and therapy. Gold nanoparticles (AuNPs), with their distinctive physicochemical characteristics, demonstrate significant application potential in cancer therapy. For example, upon exposure to lasers of certain wavelengths, they facilitate localized heating, rendering them extremely effective in photothermal therapy. Additionally, their extensive surface area enables the conjugation of therapeutic agents or targeting molecules, increasing the accuracy of drug delivery systems. Moreover, AuNPs can serve as radiosensitizers, enhancing the efficacy of radiotherapy by boosting the radiation absorption in tumor cells. Here, we systematically reviewed the application and future directions of AuNPs in the diagnosis and treatment of PC. Although AuNPs have advantages in improving diagnostic and therapeutic efficacy, as well as minimizing damage to normal tissues, concerns about their potential toxicity and safety need to be comprehensively evaluated.
The Potential of Dutasteride for Treating Multidrug-Resistant Candida auris Infection
Authors: Borgio J. Francis , Almandil Noor B. , Selvaraj Prathas , John J. Sherlin , Alquwaie Rahaf , AlHasani Eman , Alhur Norah F. , Aldahhan Razan , AlJindan Reem , Almohazey Dana , Almofty Sarah , Dhas T. Stalin , AbdulAzeez Sayed
Published: June 2024

Novel antifungal drugs are urgently needed to treat candidiasis caused by the emerging fungal multidrug-resistant pathogen Candida auris. In this study, the most cost-effective drug repurposing technology was adopted to identify an appropriate option among the 1615 clinically approved drugs with anti-C. auris activity. High-throughput virtual screening of 1,3-beta-glucanosyltransferase inhibitors was conducted, followed by an analysis of the stability of 1,3-beta-glucanosyltransferase drug complexes and 1,3-beta-glucanosyltransferase–dutasteride metabolite interactions and the confirmation of their activity in biofilm formation and planktonic growth. The analysis identified dutasteride, a drug with no prior antifungal indications, as a potential medication for anti-auris activity in seven clinical C. auris isolates from Saudi Arabian patients. Dutasteride was effective at inhibiting biofilm formation by C. auris while also causing a significant reduction in planktonic growth. Dutasteride treatment resulted in disruption of the cell membrane, the lysis of cells, and crushed surfaces on C. auris, and significant (p-value = 0.0057) shrinkage in the length of C. auris was noted at 100,000×. In conclusion, the use of repurposed dutasteride with anti-C. auris potential can enable rapid recovery in patients with difficult-to-treat candidiasis caused by C. auris and reduce the transmission of nosocomial infection.
Rethinking the Death of God through Kenotic Thought (with Hegel’s Help)
Authors: Bubbio Paolo Diego
Published: June 2024

This paper explores the death of God narrative through the lens of kenosis, drawing insights from thinkers such as Marcel, Heidegger, Vattimo, and Girard. It investigates the implications of kenotic thought for contemporary religious and philosophical discourse, exploring various interpretations of kenosis, ranging from Altizer and Žižek’s apocalyptic views to Vattimo’s more hopeful perspective. Through critical engagement with these viewpoints, this paper advocates for a nuanced understanding of kenosis inspired by Hegel, one that bypasses both radical theology and excessive optimism. Methodologically, this study adopts a hermeneutic approach, analyzing key texts and engaging in philosophical dialogue. This paper concludes that rethinking kenotic thought could provide a robust framework for grappling with the death of God in the contemporary context, offering avenues for ethical reflection, social critique, and speculative renewal.
Modulated Short-Time Fourier-Transform-Based Nonstationary Signal Decomposition for Dual-Comb Ranging Systems
Authors: Han Ningning , Wang Chao , Wu Zhiyang , Zhai Xiaoyu , Pei Yongzhen , Shi Haonan , Li Xiaobo
Published: June 2024

Analyzing and breaking down nonstationary signals into their primary components is significant in various optical applications. In this work, we design a direct, localized, and mathematically rigorous method for nonstationary signals by employing a modulated short-time Fourier transform (MSTFT) that can be implemented efficiently using fast Fourier transform, subsequently isolating energy-concentrated sets through an approximate threshold process, allowing us to directly retrieve instantaneous frequencies and signal components by determining the maximum frequency within each set. MSTFT provides a new insight into the time-frequency analysis in multicomponent signal separation and can be extended to other time-frequency transforms. Beyond the analysis of the synthetic, we also perform real dual-comb ranging signals under turbid water, and the results show an approximate 1.5 dB improvement in peak signal-to-noise ratio, further demonstrating the effectiveness of our method in challenging conditions.
Drought Protective Effects of Exogenous ABA and Kinetin on Lettuce: Sugar Content, Antioxidant Enzyme Activity, and Productivity
Authors: Urbutis Martynas , Vaseva Irina I. , Simova-Stoilova Lyudmila , Todorova Dessislava , Pukalskas Audrius , Samuolienė Giedrė
Published: June 2024

Drought is an environmental stressor that significantly impacts plant growth and development. Comprehending the complexity of drought stress and water utilization in the context of plant growth and development holds significant importance for sustainable agriculture. The aim of this study was to evaluate the effect of exogenously applied phytohormones on lettuce (Lactuca sativa L.) sugar content profiles and antioxidant enzyme activity and productivity. Lettuce plants were grown under normal and drought conditions in a growth chamber with a photoperiod of 14/10 h (day/night). Kinetin and abscisic acid were applied separately and in combinations when the second leaf was fully expanded. The results showed that sugar accumulation and productivity of the pretreated plants under drought were significantly higher than the controls. The perspective offered by this work showed that growth-related and stress-related phytohormones significantly influenced plant sugar metabolism, metabolic profiles, and productivity, thus enabling the control of yield and quality.
Effect of Inorganic Fillers on Electrical and Mechanical Properties of Ceramizable Silicone Rubber
Authors: Yang Mingyuan , Qiao Jingqi , Su Bolin , Xiao Yongjian , Kang Shenglin , Li Yuchen , Cao Hanzhong , Tang Hongchuan , Zhao Xuetong
Published: June 2024

Ceramizable silicone rubber (CSR) composed of silicone rubber matrix and inorganic fillers can be transformed into a dense flame-retardant ceramic upon encountering high temperatures or flames. Conventionally, CSR can be sintered into a dense ceramic at temperatures above 1000 °C, which is higher than the melting point of a copper conductor used in a power cable. In this study, the vulcanization process and mass ratio of inorganic fillers of CSR were studied to lower its ceramization temperature to 950 °C. The electrical and mechanical properties of CSRs and their ceramic bulks were studied with various ratios of wollastonite and muscovite. It was found that the CSR samples could be successfully fabricated using a two-step vulcanization technique (at 120 °C and 150 °C, respectively). As a high ratio of muscovite filler was introduced into the CSR, the sample presented a high dc electrical resistivity of 6.713 × 1014 Ω·cm, and a low dielectric constant of 4.3 and dielectric loss of 0.025 at 50 Hz. After the thermal sintering (at 950 °C for 1 h) of the CSR sample with a high ratio of muscovite, the ceramic sample exhibits a dense microstructure without any pores. The ceramic also demonstrates excellent insulating properties, with a volume resistivity of 8.69 × 1011 Ω·cm, and a low dielectric loss of 0.01 at 50 Hz. Meanwhile, the three-point bending strength of the ceramic sample reaches a value of 110.03 MPa. This study provides a potential route to fabricate CSR used for fire-resistant cables.
Numerical Analysis of Laminated Veneer Lumber Beams Strengthened with Various Carbon Composites
Authors: Bakalarz Michał Marcin , Kossakowski Paweł Grzegorz
Published: June 2024

Among the many benefits of implementing numerical analysis on real objects, economic and environmental considerations are likely the most important ones. Nonetheless, it is also crucial to constrain the duration and space necessary for conducting experimental investigations. Although these benefits are clear, the applicability of such models must be appropriately verified. This research subjected validation of numerical models depicting the behavior of unstrengthened and strengthened laminated veneer lumber (LVL) beams. As a reinforcement, a carbon fiber reinforced polymer (CFRP) sheet and laminates were used. Experiments were conducted on full-scale members within the framework of the so-called four-point bending testing method. Numerical simulations were performed using the Abaqus software. Two types of material models were examined for laminated veneer lumber: linearly elastic and linearly elastic–perfectly plastic with Hill’s yield criterion. A distinction was made in the material properties of carbon composites based on their location on the height of the cross-section. The outlined numerical models accurately depict the behavior of real structural elements. The precision of predicting load-bearing capacity amounts to a few percent for strengthened beams and a maximum of eleven percent for unstrengthened beams. The relative deviation between numerical and experimental values of bending stiffness was at a maximum of seven percent. Applying the elastic–plastic model enables accurate representation of the load versus deflection relation and the distribution of stress and deformation of strengthened beams. Based on the findings, directives were provided for further optimization of the positioning of composite reinforcement along the span of the beam. Reinforcement design of existing laminated veneer lumber members can be made using presented methodology.
Physicochemical Characterization and Biological Properties of Polysaccharides from Alpiniae oxyphyllae Fructus
Authors: Wang Risi , Ruan Xinmei , Chen Jun , Deng Lizhen , Zhou Wei , Shuai Xixiang , Liang Ruihong , Dai Taotao
Published: June 2024

Polysaccharides (AOPs) were extracted from Alpiniae oxyphyllae fructus using three distinct methods: hot water (AOP-HW), hydrochloric acid (AOP-AC), and NaOH/NaBH4 (AOP-AL). This study systematically investigated and compared the physicochemical properties, structural characteristics, antioxidant activities, and α-amylase inhibitory activities of the extracted polysaccharides. Among the three AOPs, AOP-AC exhibited the highest yield (13.76%) and neutral sugar content (80.57%), but had the lowest molecular weight (121.28 kDa). Conversely, AOP-HW had the lowest yield (4.54%) but the highest molecular weight (385.42 kDa). AOP-AL was predominantly composed of arabinose (28.42 mol%), galacturonic acid (17.61 mol%), and galactose (17.09 mol%), while glucose was the major sugar in both AOP-HW (52.31 mol%) and AOP-AC (94.77 mol%). Functionally, AOP-AL demonstrated superior scavenging activities against DPPH, hydroxyl, and ABTS radicals, whereas AOP-AC exhibited the strongest inhibitory effect on α-amylase. These findings indicate that the extraction solvent significantly influences the physicochemical and biological properties of AOPs, thus guiding the selection of appropriate extraction methods for specific applications. The results of this study have broad implications for industries seeking natural polysaccharides with antioxidant and enzymatic inhibitory properties.
A Glacial–Interglacial Malacofauna Record from the Titel Loess Plateau, Serbia, between ~350 and 250 ka
Authors: Radaković Milica G. , Gavrilović Bojan , Gavrilov Milivoj B. , Marković Rastko S. , Hao Qingzhen , Schaetzl Randall J. , Zeeden Christian , Cai Binggui , Perić Zoran M. , Antić Aleksandar , Lukić Tin , Marković Slobodan B.
Published: June 2024

We present data on molluscan fauna within the L3 loess unit (and partially within the S3 paleosol) from the key loess section of Veliki Surduk in Serbia. The section correlates to Marine Isotope Stage (MIS) 8 and late MIS 9 and, thus, spans the time frame from ~350 to 250 ka. The Veliki Surduk loess–paleosol sequence (LPS) is located on the northwestern margin of the Titel loess plateau and comprises ~30 m of sediments. Our focus is on a 5.4 m thick sedimentary interval, which was sampled at 20 cm increments, each sample covering approximately 2 ky. Nine mollusk species were identified in the loess sequence: Granaria frumentum, Helicopsis striata, Pupilla triplicata, Chondrula tridens, Pupilla muscorum, Succinella oblonga, Punctum pygmaeum, Vallonia costata, and Vitrina pellucida, as well as a few unidentified slug taxa (Limacidae, Agriolimacidae, and Milacidae). The majority of the snail assemblage occurs at the transition between MIS 9 and MIS 8, suggesting a mostly dry climate and an open and steppe-like habitat. The fauna identified in the upper part of the paleosol layer S3, below the L3 unit, indicated aridification.
Talmud Today: A Politics of Forgetting
Authors: Dolgopolski Sergey
Published: June 2024

The article deals with the way in which the “theological” as the question of the Biblical G-d’s involvement in the world, as in the Talmuds, and in light of Heidegger’s thought about forgetting and forgetfulness (Verborgenheit and Vergessenheit), becomes a political question about the attitude of the Jew and Israel toward the Heimat. In Heidegger, forgetting is about beings hiding from the view rather than about a psychological or “subjective” process to which forgetting has been reduced in modernity. The Heimat hides from the persons’ life, no matter how strongly the persons strive for their Heimat “subjectively” or politically, Heidegger argues. The essay further detects a residual modernity and subjectivism in Heidegger’s concession to forgetting as only a secondary operation, a loss, in comparison to the primary, “authentic” relationship to the Heimat, which, for him, one can and should hope for. That residual modern subjectivity in Heidegger enables and necessitates a comparison with the roles forgetting plays in relationships between G-d, Israel, and the Land in the two Talmuds as, similarly to Heidegger, dealing with and working against forgetting, if not Being, then the Law of the mutual obligations between G-d and Israel. The resulting analysis distills a conundrum in the Palestinian rabbis. Delivery on Israel’s obligations towards G-d conditions Israel’s arrival to the Land, that is to say Israel’s fully successful exodus from Egypt. Yet, any clear memory of, and delivery on, these obligations, i.e., any humanly delivered testament to the law of G-d, constitutes an acute danger of forgetting masked as a would-be-certitude in the “memory” of the would-be-original law. Regaining the status of a full-fledged, never-tamed primordial power in relationships between G-d and Israel, forgetting, in the Palestinian rabbinic thought, undermines the deployment of logos as a way to formulate the Law fully. Letting the G-d in the world, logos however proves prone to reducing G-d to (a) theos, thus drawing the G-d into disappearance and forgetting. Such a counter-current to the copulation of theos with logos, the primordial power of forgetting operates even before any memory captured in words and images becomes possible. Arriving from antiquity to modernity, this counter-current continues to operate despite the currently prevalent demotion of forgetting to a subjective political act of a person or nation.
Religion and Violence: Help from the Egyptian Desert
Authors: Parsons Stuart E.
Published: June 2024

Support for political violence by fundamentalist religious movements is both wide-spread and problematic, and now especially in Christian fundamentalist circles. To address this, this essay describes important components of the sophisticated ascetic and contemplative theory of spirituality of the fourth-century desert Christian spiritual master Evagrius of Pontus. Then, based on his theory, this essay offers guidance to modern-day Christian and non-Christian clergy who want to avoid alienating their congregations through partisan political stances, but who nevertheless seek to reduce those mental, emotional, and relational pathologies in their congregations which predispose passive and active support for political violence.
Religious and Spiritual Diversity in Multiple Modernities: A Decolonial Perspective Focusing on Peripheral Religious Expressions
Authors: Parker Cristián
Published: June 2024

This paper challenges the World Religion Paradigm (WRP) dominating religious studies, advocating for a decolonial approach that focuses on diverse and often marginalized religious expressions. The approach that prioritizes world religions over the rich diversity of religious expressions in multiple modernities turns out to be insufficient and biased. Through theoretical research, this paper explores the implications of multiple modernities for the religious landscape. Drawing on Eisenstadt’s theory of multiple modernities, the analysis critiques linear notions of modernization and secularization, and it highlights the complex interplay between religious centers and peripheries. It develops a critical examination of how the theory of the Axial Age, by prioritizing elites and centers in the historical genesis of world religions, generates a preconception that overlooks the religious and spiritual productivity of the peripheries, which persists within current interpretative frameworks. To emphasize the dynamic between center and periphery as a key factor in understanding religious diversity, the text proposes some theoretical theses. By embracing a diversity paradigm and decolonizing frameworks, this paper offers a more inclusive understanding of religious phenomena, contributing to a broader discourse on religion and spirituality beyond Eurocentric perspectives.
“Relief of Man’s Estate”: The Theological Origins of the Modern Biomedical Project
Authors: Daly Todd T. W.
Published: June 2024

In recent years, medicine has been increasingly described as “Baconian”, in reference to the scientific methodology laid out by Francis Bacon (1561–1626), who, in criticizing Aristotle’s natural philosophy, called for cultivating useful knowledge in order to eradicate disease and extend human life by attenuating aging. Contemporary medicine is often described as “Baconian” insofar as it is devoted to the relief of suffering and the expansion of choice. These two features continue to exert pressure on medicine to expand understandings of both suffering and wellness. Recent attempts to reclassify human aging as a disease, for instance, bear witness to the Baconian impulse. In this article, I discuss and critique the religious origins of Bacon’s call for a new kind of practical rationality in service of improving humanity, showing that they were deeply theological and considerably informed by events recorded in the biblical book of Genesis. I will also argue that the theological nature of Bacon’s program, while theocentric in nature, suffers from inattention to Christology, which challenges Bacon’s theology and the Baconian Project. Attending to Christological concerns modifies Bacon’s approach to bioethics, which recognizes both the fallenness of creation and the power of medicine to address the human condition, especially human aging.
Successfully Anticipated Difficult Airway Management of a “Can Ventilate, but Cannot Intubate” Situation for Urgent Laparoscopic Appendectomy in a Patient with Duchenne Muscular Dystrophy
Authors: Brunner Fabian P. , Neth Philippe , Kaserer Alexander
Published: June 2024

Background: Airway management in Duchenne patients can be challenging. We present a case of an anticipated difficult airway in a 24-year-old Duchenne patient that was managed by planning different suitable strategies based on the unanticipated difficult airway algorithm of the Difficult Airway Society (DAS). Case presentation: The patient initially presented with appendicitis, requiring a laparoscopic appendectomy within 6 h. Due to the underlying condition and a known difficult airway, we anticipated potential airway problems and successfully managed the “can ventilate but cannot intubate” situation using the algorithm. The difficult airway was attributed to reduced mandibular mobility, limited inclination or reclination, a large tongue, prominent incisors, and a posteriorly positioned epiglottis. Despite thorough preparation and team briefing, we experienced three failed intubation attempts. Considering limited nighttime resources, the urgency of the surgery, the need for a tube for laparoscopy, and the risk of exacerbating airway issues, we made the decision to awaken the patient and wait for a second attempt after the epiglottis swelling had subsided. We used reversible, short-acting agents for induction, enabling us to continue with the algorithm within the allotted timeframe. In a second stage, we successfully performed fiberoptic-guided intubation via a supraglottic airway device using the Aintree intubation catheter, utilizing more favorable resources. Conclusions: For a patient with Duchenne muscular dystrophy and a difficult airway, advanced expertise is critical. Detailed anesthesia planning, clear team communication, and the use of reversible, short-acting agents are crucial. Adherence to the Difficult Airway Society guidelines is essential for safe airway management.
VALNet: Vision-Based Autonomous Landing with Airport Runway Instance Segmentation
Authors: Wang Qiang , Feng Wenquan , Zhao Hongbo , Liu Binghao , Lyu Shuchang
Published: June 2024

Visual navigation, characterized by its autonomous capabilities, cost effectiveness, and robust resistance to interference, serves as the foundation for vision-based autonomous landing systems. These systems rely heavily on runway instance segmentation, which accurately divides runway areas and provides precise information for unmanned aerial vehicle (UAV) navigation. However, current research primarily focuses on runway detection but lacks relevant runway instance segmentation datasets. To address this research gap, we created the Runway Landing Dataset (RLD), a benchmark dataset that focuses on runway instance segmentation mainly based on X-Plane. To overcome the challenges of large-scale changes and input image angle differences in runway instance segmentation tasks, we propose a vision-based autonomous landing segmentation network (VALNet) that uses band-pass filters, where a Context Enhancement Module (CEM) guides the model to learn adaptive “band” information through heatmaps, while an Orientation Adaptation Module (OAM) of a triple-channel architecture to fully utilize rotation information enhances the model’s ability to capture input image rotation transformations. Extensive experiments on RLD demonstrate that the new method has significantly improved performance. The visualization results further confirm the effectiveness and interpretability of VALNet in the face of large-scale changes and angle differences. This research not only advances the development of runway instance segmentation but also highlights the potential application value of VALNet in vision-based autonomous landing systems. Additionally, RLD is publicly available.
Simultaneous Determination of Multiresidues of Pesticides and Veterinary Drugs in Agricultural Soil Using QuEChERS and UHPLC–MS/MS
Authors: Vicari Michele C. , Facco Janice F. , Peixoto Sandra C. , de Carvalho Gabriel S. , Floriano Luana , Prestes Osmar D. , Adaime Martha B. , Zanella Renato
Published: June 2024

Soil is one of the main destinations for pesticides and veterinary drugs used in agriculture and animal production. The negative consequences of the accumulation of these compounds in the environment make it important to monitor these compounds in the soil. In this study, we compared different extraction procedures using solvent shaking, ultrasound, or QuEChERS, and their combinations, for the simultaneous determination of 75 pesticide and seven veterinary drug residues in agricultural soil by ultra-high performance liquid chromatography coupled to serial mass spectrometry (UHPLC–MS/MS). The method using QuEChERS combined with shaking showed the best results for soil using the addition of water, followed by extraction with acetonitrile acidified with acetic acid and shaking in a shaker. For partitioning, anhydrous magnesium sulfate and anhydrous sodium acetate were used. The extract was centrifuged, filtered, and diluted (1:4, v/v) in water for determination by UHPLC–MS/MS. Method validation showed adequate accuracy and precision results, with recoveries between 70 and 120% and RSD ≤ 20% for the vast majority of the compounds evaluated at the spike levels of 10, 25, 50, and 100 μg kg−1. The method limits of detection (LOD) and quantification (LOQ) ranged from 3.0 to 7.5 μg kg−1 and from 10 to 25 μg kg−1, respectively. The method was applied to different agricultural soil samples and proved to be efficient for routine analysis.
Economic and Environmental Assessment of Variable Rate Nitrogen Application in Potato by Fusion of Online Visible and Near Infrared (Vis-NIR) and Remote Sensing Data
Authors: Qaswar Muhammad , Bustan Danyal , Mouazen Abdul Mounem
Published: June 2024

Addressing within-field spatial variability for nitrogen (N) management to avoid over and under-use of nitrogen is crucial for optimizing crop productivity and ensuring environmental sustainability. In this study, we investigated the economic, environmental, and agronomic benefits of variable rate nitrogen application in potato (Solanum tuberosum L.). An online visible and near-infrared (vis-NIR) spectroscopy sensor was utilized to predict soil moisture content (MC), pH, total organic carbon (TOC), extractable phosphorus (P), potassium (K), magnesium (Mg), and cation exchange capacity (CEC) using a partial least squares regression (PLSR) models. The crop’s normalized difference vegetation index (NDVI) from Sentinel-2 satellite images was incorporated into online measured soil data to derive fertility management zones (MZs) maps after homogenous raster and clustering analyses. The MZs maps were categorized into high fertile (VR-H), medium–high fertile (VR-MH), medium–low fertile (VR-ML), and low fertile (VR-L) zones. A parallel strip experiment compared variable rate nitrogen (VR-N) with uniform rate (UR) treatments, adjusting nitrogen levels based on fertility zones as 50% less for VR-H, 25% less for VR-MH, 25% more for VR-ML, and 50% more for VR-L zones compared to the UR treatment. The results showed that the VR-H zone received a 50% reduction in N fertilizer input and demonstrated a significantly higher crop yield compared to the UR treatment. This implies a potential reduction in negative environmental impact by lowering fertilizer costs while maintaining robust crop yields. In total, the VR-N treatment received an additional 1.2 Kg/ha of nitrogen input, resulting in a crop yield increase of 1.89 tons/ha. The relative gross margin for the VR-N treatment compared to the UR treatment is 374.83 EUR/ha, indicating substantial profitability for the farmer. To further optimize environmental benefits and profitability, additional research is needed to explore site-specific applications of all farm resources through precision agricultural technologies.