bluuebunny/crossref_metadata_2025 huggingface dataset:
ПОСТУЛАТИ БЕЗПЕКООРІЄНТОВАНОГО УПРАВЛІННЯ ПІДПРИЄМСТВОМ
Authors: Мороз Роман , Загороднюк Оксана
Published: December 2024

Стаття присвячена узагальненню основних постулатів безпекоорієнтованого управління підприємством. Визначено актуальність безпекоорієнтованого управління підприємством в умовах воєнного стану, оскільки крім «класичних» загроз продукуються загрози з руйнування чи знищення майна підприємства, втрати земельного фонду, мобілізація працівників тощо. Постулатами безпекоорієнтованого управління є: виявлення зон ризиків на основі якісного статистичного аналізу без елементів суб’єктивізму, оцінювання ризиків і загроз безпеці держави з обов’язковим напрацювання способів їх мінімізації та усунення, запобігання, виявлення, припинення, розслідування правопорушень, а також складання аналітичних висновків і рекомендацій з метою підвищення ефективності прийняття управлінських рішень. Безпекоорієнтоване управління підприємством базується на стійкості до внутрішніх та зовнішніх загроз, високій конкурентоспроможності, сталому та збалансованому зростанні.
СУЧАСНІ ВИКЛИКИ ТА ІННОВАЦІЙНІ ПІДХОДИ В УПРАВЛІННІ ЛЮДСЬКИМ КАПІТАЛОМ: ГЛОБАЛЬНИЙ ТА УКРАЇНСЬКИЙ КОНТЕКСТИ
Authors: Орєхова Альвіна , Гома Олег
Published: December 2024

У дослідженні узагальнено сучасні виклики та інноваційні підходи в управлінні людським капіталом у глобальному та локальному контекстах, зокрема в умовах воєнного стану та опору російській агресії в Україні. Проаналізовано вплив технологічних, демографічних і соціальних трансформацій на світовий ринок праці. Систематизовано інноваційні практики в сфері управління людським капіталом, такі як програми підвищення кваліфікації, індивідуальні плани професійного зростання, впровадження коучингу, розвиток SoftSkills, гейміфікація, програми well-being. Розглянуто виклики, зумовлені війною в Україні, зокрема міграцію трудових ресурсів, руйнування інфраструктури, дефіцит кадрів, психологічний стрес і зниження інвестицій у розвиток персоналу. Виділені адаптаційні стратегії в управлінні людським капіталом для українських компаній.
ВПЛИВ СОЦІАЛЬНО ВІДПОВІДАЛЬНОГО МАРКЕТИНГУ НА УПРАВЛІННЯ ЛОГІСТИЧНИМИ ЛАНЦЮГАМИ ПОСТАЧАННЯ
Authors: Плахотнікова Лариса
Published: December 2024

У статті розглянуто теоретичні основи та розвиток концепції соціально-етичного маркетингу та її вплив на управління логістичним процесами, а саме ланцюгами поставок, як структури сучасного логістичного бізнесу. У статті робиться акцент на можливості інтерпретації соціально відповідального маркетингу як прикладного втілення концепції соціальної відповідальності бізнесу, спрямованого на формування довгострокових партнерських відносин зі своїми споживачами шляхом задоволення їх потреб і отримання споживчих цінностей таким чином, щоб це надавало довгостроковий позитивний вплив як на їх благополуччя, так і на навколишнє середовище, благополуччя суспільства в цілому, а також фінансове і ринкове становище суб’єктів логістичної діяльності. Методологічною та теоретичною основою дослідження стали наукові праці вітчизняних та зарубіжних авторів з проблем, пов’язаних із забезпеченням розвитку логістичної системи та концепцією соціальної відповідальності бізнесу. У статті використано метод аналізу, порівняння, синтезу даних, дослідження базується на системному підході до розглянутих проблем, вивченні їх взаємозв’язку та розвитку. Результатами дослідження є розробка теоретико-методологічних засад та відповідних практичних рекомендацій, які дозволять розробити ефективні стратегії логістичних підприємств та підвищити ефективність і якість управління ланцюгами поставок.
РОЛЬ ОБЛІКОВО-АНАЛІТИЧНИХ СИСТЕМ У ЗАБЕЗПЕЧЕННІ ІНВЕСТИЦІЙНОЇ БЕЗПЕКИ В АГРАРНОМУ СЕКТОРІ УКРАЇНИ
Authors: Рижикова Наталія , Бірченко Наталія , Богомолов Олексій
Published: December 2024

Стаття присвячена актуальним питанням значення обліково-аналітичних систем (ОАС) для забезпечення інвестиційної безпеки в аграрному секторі. У ній аналізується, як ОАС сприяють підвищенню ефективності управління ресурсами, контролю за фінансовими потоками та своєчасному виявленню ризиків. Автори підкреслюють, що надійна інформаційна база, яку забезпечують ці системи, є основою для прийняття обґрунтованих управлінських рішень. Стаття також розглядає вплив ОАС на інвестиційну політику підприємств та їх адаптацію до сучасних умов ринку. Висновки статті акцентують на необхідності впровадження сучасних обліково-аналітичних систем для забезпечення інвестиційної безпеки та підвищення конкурентоспроможності аграрних підприємств в Україні.
КОНЦЕПЦІЯ ВІДКРИТИХ ІННОВАЦІЙ ЯК СУЧАСНА ПАРАДИГМА СТАЛОГО РОЗВИТКУ
Authors: Побережна Заріна , Левшук Антон
Published: December 2024

У статті досліджено зміст та особливості концепції відкритих інновацій як сучасної парадигми сталого розвитку. Запропоновано визначати концепцію відкритих інновацій як системний підхід до інноваційної діяльності, який передбачає активне залучення зовнішніх знань, ресурсів і партнерів для розробки нових продуктів, послуг або технологій. Визначено, що роль концепції відкритих інновацій у сталому розвитку, можна простежити за наступними ключовими аспектами: сприяння екологічній стійкості; ефективне використання ресурсів; прискорення інноваційного процесу; зниження ризиків; створення інноваційних екосистем; подолання соціальних бар'єрів; зміцнення регіонального розвитку; підтримка наукових досліджень і технічного прогресу. Охарактеризовано організаційні форми реалізації концепції відкритих інновацій у середовищі сучасних підприємств. Обгрунтовано, що для більш активного запровадження концепції відкритих інновацій у середовище сучасних підприємств необхідно використовувати широкий спектр сучасних цифрових технологій.
ОРГАНІЗАЦІЙНІ ТА МЕТОДОЛОГІЧНІ АСПЕКТИ ОБЛІКОВОЇ ПОЛІТИКИ ЛОГІСТИЧНОГО ПІДПРИЄМСТВА ЗА МСФЗ
Authors: Ромашко Ольга , Черевань Анастасія
Published: December 2024

У статті розкрито сучасний стан логістичної галузі в Україні. Охарактеризовано основні об'єкти облікової політики логістичних підприємств, зокрема основні засоби, оренда, запаси, доходи та витрати у розрізі собівартості наданих послуг. Описано інформацію, яка має висвітлюватись в обліковій політиці та фінансовій звітності логістичних компаній щодо вищеперерахованих об’єктів згідно з Міжнародними стандартами фінансової звітності. Надано рекомендації щодо формування деяких складових облікової політики за МСФЗ і робочого плану рахунків, щодо якого, зокрема, запропоновано введення аналітичних рахунків у розрізі отриманих доходів та здійснених витрат за кожним видом послуг. Ці рекомендації та пропозиції можуть бути використані логістичними компаніями при веденні бухгалтерського обліку та складанні фінансової звітності з метою надання усім користувачам повної, зрозумілої, корисної та доречної інформації.
РОЗРОБКА СИСТЕМИ УПРАВЛІННЯ ОНЛАЙН-МАГАЗИНОМ: ВІД АВТОМАТИЗАЦІЇ ЗАМОВЛЕНЬ ДО ІНТЕЛЕКТУАЛЬНИХ РЕКОМЕНДАЦІЙ
Authors: Домашенко Данило , Домашенко Світлана , Шило Галина
Published: December 2024

У статті представлено результати дослідження та розробки модульної системи управління онлайн-магазином для автоматизації бізнес-процесів та впровадження рекомендаційних систем. Проведено аналіз існуючих підходів до автоматизації онлайн-торгівлі та виявлено їх ключові переваги та недоліки. Досліджено основні методи побудови рекомендаційних систем та обґрунтовано підхід на основі аналізу транзакцій. Обґрунтовано вибір алгоритму Apriori для реалізації рекомендаційної системи, який забезпечує виявлення асоціативних правил без необхідності зберігання персональної історії покупок. Розроблено архітектуру системи на основі модульного підходу, що забезпечує гнучкість, масштабованість і можливість адаптації функціоналу до потреб конкретного бізнесу. Реалізовано механізм генерації персоналізованих пропозицій на основі аналізу транзакційних даних, що підвищує швидкість і точність рекомендацій. Запропоновано метод оновлення бази даних для забезпечення актуальності транзакцій та оптимізації обсягу збережених даних. Визначено напрями подальшого вдосконалення системи через інтеграцію API для зовнішніх платформ, розширення функціоналу аналітики та використання алгоритмів машинного навчання для підвищення точності рекомендацій.
Impacto de la Inteligencia Artificial Generativa en la eficiencia, calidad e innovación en la producción de Recursos Educativos Abiertos para MOOCS
Authors: Carbonell-Alcocer Alejandro , Sanchez-Acedo Alberto , Benitez-Aranda Nerea , Gertrudix Manuel
Published: December 2024

Esta investigación analiza el impacto de la Inteligencia Artificial Generativa (IAG) en la creación de contenidos audiovisuales y multimedia mediante un estudio comparativo de Recursos Educativos Abiertos (REA) desarrollados (n = 121) en dos MOOC enfocados en combatir la desinformación, donde uno emplea IAG y el otro no. El análisis compara tanto los procesos de producción como los resultados obtenidos en dimensiones clave como eficiencia, calidad técnica y formal y accesibilidad a las herramientas. Los resultados muestran que la IAG mejora la eficiencia y calidad en la producción de los rea, facilitando la creación de contenidos de alta calidad con un menor costo. Su uso permite producciones más accesibles y escalables ampliando las posibilidades de creación de contenido educativo digital avanzado.
Being critical is innovative: Constructive patriotism and collective actions are related to social entrepreneurship intentions
Authors: Simić Andrej
Published: December 2024

Social entrepreneurship, characterized by the development of innovative business solutions for sociocultural and environmental issues, has attracted the interest of psychologists in recent years. Previous work has highlighted the important role of personality and cognitive factors in understanding why individuals become social entrepreneurs. However, less attention has been dedicated to how different variables studied in the group processes literature relate to the formation of intentions toward social entrepreneurship. One possible approach to understanding psychological factors that correlate with social entrepreneurship intentions is the feeling of attachment to one's national group. Constructive patriotism, defined by the support for the ingroup through constructive criticism, shows stronger relations with progressivism and innovation than blind patriotism. We proposed that constructive patriotism, but not its blind counterpart, positively predicts social entrepreneurship intentions by increasing positive change collective action intentions. Two cross-sectional studies (N = 514) showed that constructive, but not blind patriotism, was positively related to social entrepreneurship intentions. Furthermore, constructive patriotism was related to social entrepreneurship intentions through greater levels of collective action intentions. The same mediational pattern did not hold when blind patriotism was considered a predictor of social entrepreneurship intentions. Specifically, being devoted to one's nation and questioning its harmful policies might predict social entrepreneurship intentions through stronger inclinations for social change actions.
Dating a vegetarian? Perception of masculinity, attractiveness, and the willingness to date vegetarians
Authors: Adamczyk Dominika , Nezlek John B. , Maison Dominika
Published: December 2024

The study examined how following a vegetarian diet affects the attractiveness of a potential dating partner among those who do not follow a vegetarian diet. Participants, 404 heterosexual meat-eaters, took part in an online experiment in which they evaluated the dating profile of a target person who was described as following a vegetarian diet for health, ethical, or environmental reasons, and a control condition that had no description of the target’s diet. Participants rated the target in terms of a feeling thermometer, willingness to date, gender congruence, and possession of masculine and feminine traits. Participant’s level of identification as a meat-eater was also measured. A series of two (participant gender) by four (target diet) ANOVAs found significant interactions in the analyses of the feeling thermometer ratings, showing that women viewed ethically motivated targets less positively than men did. We also found significant main effects of target diet in willingness to date, gender congruence, and possession of feminine and masculine traits. Meat-eaters evaluated targets with no diet information more positively than the health-motivated target. Controlling for identification as a meat-eater, women evaluated ethically-motivated targets as having less feminine traits than men did. The present results suggest that being a vegetarian makes a person less attractive as a potential partner among omnivores, who constitute the majority of people in most Western, industrialized countries.
The economic role of logistics quality assurance in the era of digitalisation
Authors: Nagy Gábor
Published: December 2024

Digitalisation has fundamentally transformed the logistics sector, elevating the importance of quality assurance as a cornerstone for operational efficiency, cost management, and customer satisfaction. As logistics processes become increasingly complex and data-driven, the role of quality assurance extends beyond traditional frameworks to embrace cutting-edge technologies such as artificial intelligence, blockchain, and the Internet of Things (IoT). This paper explores the economic implications of integrating these innovations into logistics quality assurance, focusing on their capacity to reduce operational costs, enhance supply chain transparency, and foster long-term customer loyalty. Through a detailed analysis, the study demonstrates how the convergence of digitalisation and quality assurance facilitates real-time monitoring, predictive analytics, and automation, resulting in significant competitive advantages. By adopting a hybrid approach that integrates traditional quality management principles with advanced digital tools, logistics companies can unlock unprecedented economic and strategic opportunities, positioning themselves as leaders in an increasingly global and digitised marketplace.
Intelligent material handling machines
Authors: Telek Péter
Published: December 2024

Automatic material handling is basically used to implement the automatic movement of goods, but due to today's expectations, this technically requires high-level computer control of various sensing, control, and monitoring tasks. Due to flexible service needs, these tasks require dynamic implementation, which may require the use of intelligent solutions. In this article, I will review the interpretation and role of intelligent material handling in modern service systems, and outline the concept and levels of intelligent material handling machines in terms of different device versions. In addition, I will present the intelligent solutions and their application areas encountered in logistics activities today through examples.
Tracking systems in logistics
Authors: Nagy Sándor , Tamás Péter
Published: December 2024

With the spread of globalization, there is an increasing need for unique identification and traceability of products. This affects all elements of the supply chain, including warehousing. Identification of products, means of transport and storage facilities is a fundamental need in warehouse processes. Without it, modern industrial operations are unthinkable. With the advance of Industry 4.0, new technologies and new solutions have emerged, which can be applied when modernizing or designing a new system, weighing up the advantages and disadvantages. Our publication tries to help by describing and comparing the different systems. In addition to the three most common solutions, we also look at the developments expected in the near future, which are extensions and improvements of the current systems.
From steam to IoT-supported cross-border logistics platforms: The social, economic, and logistical impacts of the industrial revolutions
Authors: Bányai Tamás
Published: December 2024

This paper explores the economic, social, and logistical impacts of the four industrial revolutions, highlighting how each phase of industrialization transformed societies and economies. The analysis covers shifts in production methods, labor dynamics, and market structures that reshaped economic frameworks and influenced wealth distribution, job creation, and industry specialization. Social consequences, including urbanization, migration, and the development of new social classes, are examined to understand the broader implications on family dynamics, labor rights, and quality of life. The study also addresses the critical role of logistical advancements – from steam transportation to digital supply chains – in expanding markets and driving globalization.
Application of LSTM model for forecasting production orders
Authors: Veres Péter , Baráth Zoltán
Published: December 2024

Production planning is critical in modern industry, especially in custom machine manufacturing, where efficiency and meeting deadlines are essential. Time series analysis has become pivotal in optimizing production systems in recent years. This study presents the application of LSTM neural networks for production scheduling predictions, modeling temporal patterns and seasonal fluctuations based on historical data. The goal is to enable more efficient planning and accurate delivery times, thereby improving overall production performance. Preliminary results suggest that LSTM can outperform traditional statistical models, such as linear regression. It is crucial to tailor the model to the company's specific needs and relevant data.
Digitalizing quality assurance in logistics: trends and challenges
Authors: Nagy Gábor , Szentesi Szabolcs , Varga Károly Attila
Published: December 2024

The rapid advancement of digital technologies has revolutionized logistics networks, offering unprecedented opportunities for enhancing quality assurance. This paper continues the discussion on the role of digitalization in logistics, focusing on the latest technological innovations, implementation challenges, and future trends. By examining the impact of digital tools such as IoT, AI, and blockchain on logistics quality assurance, this paper provides a comprehensive overview of how companies can leverage these technologies to improve operational efficiency and meet the growing demands of the global market. The paper also addresses the challenges associated with digital transformation, including cybersecurity risks and implementation barriers, and proposes strategies for overcoming these obstacles. Finally, the paper explores emerging trends in logistics digitalization and their implications for the future of supply chain management.
Innovation of Moringa Leaf and Eel Noodle as Functional Food Diversification for Stunting Prevention
Authors: Usman  , Zulkarnain Sulaiman  , Fitriani Umar
Published: December 2024

The problem of stunting is still a scourge for future generations of the Indonesian nation. Local foods that have good nutritional content are Moringa leaves and eel. In this condition, moringa and eel leaf combination noodle formulation innovation is needed as a functional food. The study's objectives were 1) to determine the subject's acceptance of the moringa and eel leaf noodle innovation and 2) to determine whether there is an effect of giving moringa and eel leaf noodle innovation with stunting prevention. This type of research is quasi-experimental with a One-group pre-test and post-test design. This research was conducted in Parepare City and Sidenreng Rappang district in July - August 2024. The test sample selected was 34 people, with details of 17 people in the treatment group and 17 in the control group. Data analysis to determine acceptability was an organoleptic test, while to determine the relationship between the provision of moringa and eel leaf noodle innovation with stunting prevention was using quasi-experimental through Paired sample t-test mean difference between pre-test and post-test with a significant level of 95% (α = 0.05). The results showed that the average assessment of mothers of toddlers towards noodles containing moringa and eel leaves, especially in the indicators of color and texture, reached the criteria of liking, while aroma and taste obtained criteria quite like. The average body weight of toddlers before giving the noodles was 9.74 kg, and after giving, the average body weight of toddlers increased by 0.51 kg to 10.25 kg. The statistical analysis results showed a p-value = 0.002, which is smaller than the significance level α (0.05), implying a significant effect of the provision of moringa and eel leaf noodle innovation on stunting prevention. The study concludes that moringa and eel leaf noodle formulations affect stunting prevention.
Monitoring of Potassium Content in Wastewater Treatment Plants
Authors: Tutor László , Béres András , Barczi András , Horváth Márk Kálmán , Géczi Gábor
Published: December 2024

Partially treated wastewater can potentially provide a reliable and constant source of water and nutrients for hydroponic crop production. It is essential to determine the macronutrient content of the effluent, such as nitrogen (N), phosphorus (P), and potassium (K), to maximize the yield. Nitrogen (N) and phosphorus (P) measurements are essential daily tasks to be fulfilled, measurements were applied for multiple sources of K content only in this study, determining the exact daily content and concentration pattern. Influent and effluent K levels were measured separately.
According to measurements, it was observed that the concentration of K decreased significantly during treatment, with varying values as the wastewater passed through different treatment stages. Two locations with dissimilar technologies were sampled: Etyek, Hungary, semi-continuous batch system with suspended sludge, and South-Pest, Hungary, a continuous activated sludge system. The results were 39,7 mg/l in the influent and 7,5 mg/l in the effluent in Etyek, while South-Pest contained 28,9 mg/l in the influent and 24,5 mg/l K in the effluent respectively. Furthermore, the potassium content was measured in the Return Activated Sludge (RAS) line of South-Pest and found 50,8 mg/l concentration, however, it is being removed from wastewater with the Wasted Activated Sludge (WAS) in activated sludge systems.
Demographic trends of motor neurone disease-associated mortality from 1999-2020 in the United States
Authors: Imantalab Delaram , Sokhal Balamrit Singh , Prasanna Kumar Menon Sowmya , Kalra Seema , Muller Sara , Mallen Christian
Published: December 2024

Introduction Motor Neurone Disease (MND) is a neurodegenerative condition affecting motor neurons in spinal cord and brainstem, leading to a reduced life expectancy. This study describes demographic trends in MND-associated mortality in the United States over a 20-year period. Methods Data was extracted from the Centers for Disease Control and Prevention Wide-Ranging OnLine Data for Epidemiologic Research underlying cause of death database. All death certificates from 1999-2020 with MND (G12.2) recorded as the cause of mortality were extracted. Annual MND-associated crude mortality rates (CMR) and age-adjusted mortality rates (AAMR) per 100,000 persons with 95% confidence intervals (CI) were calculated. Joinpont regression was used to calculate the annual trends in MND-associated mortality by calculating the annual percentage change. Results Between 1999 to 2020, there were a total 140,945 MND-associated deaths. Overall AAMR was 1.9 per 100,000 persons (95% CI 1.9-1.9). Male sex had a consistently higher AAMR (2.3 per 100,000 95% CI 2.3-2.3) than female sex (1.6 per 100,000 95% CI 1.5-1.6) across the study period. White patients had higher AAMR (2.1 per 100,000 95% CI 2.0-2.1) than Black/African Americans (1.1 per 100,000 95% CI 1.0-1.1), American Indians/Alaska Natives (0.8 per 100,000 95% CI 0.7-0.9), Asians/Pacific Islanders (0.8 per 100,000 95% CI 0.7-0.9). The 3 US States with the highest AAMR were Vermont, followed by Minnesota and Maine. Conclusions There are a significant number of MND-associated deaths annually in the United States. The knowledge of these trends facilitates the design of appropriate services in areas of higher need, allowing for the introduction of pathways that support more suitable care and enhanced quality of life.
maria: A novel simulator for forecasting (sub-)mm observations
Authors: van Marrewijk J. , Morris T. W. , Mroczkowski T. , Cicone C. , Dicker S. , Di Mascolo L. , Haridas S. K. , Orlowski-Scherer J. , Rasia E. , Romero C. , Würzinger J.
Published: December 2024

Submillimeter single-dish telescopes offer two key advantages compared to interferometers: they can efficiently map larger portions of the sky and recover larger spatial scales. Nonetheless, fluctuations in the atmosphere limit the accurate retrieval of signals from astronomical sources. Therefore, we introduce a user-friendly simulator named maria to optimize scanning strategies and instrument designs to efficiently reduce atmospheric noise and filtering effects. We further use this tool to produce synthetic time streams and maps from hydrodynamical simulations, enabling a fair comparison between theory and reality. maria has implemented a suite of telescope and instrument designs intended to mimic current and future facilities. To generate synthetic time-ordered data, each mock observatory scans through the atmosphere in a configurable pattern over the celestial object. We generate evolving and location-and-time-specific weather for each of the fiducial sites using a combination of satellite and ground-based measurements. While maria is a generic virtual telescope, this study specifically focuses on mimicking broadband bolometers observing at 100 GHz. To validate our virtual telescope, we compare the mock time streams with real MUSTANG-2 observations and find that they are quantitatively similar by conducting a k-sample Anderson-Darling test resulting in p<0.001. Subsequently, we image the time-ordered data to create noise maps and mock observations of clusters of galaxies for both MUSTANG-2 and an instrument concept for the 50m Atacama Large Aperture Submillimeter Telescope (AtLAST). Furthermore, using maria, we find that a 50m dish provides the highest levels of correlation of atmospheric signals across adjacent detectors compared to smaller apertures (e.g., 42-cm and 6-m survey experiments), facilitating removal of atmospheric signal on large scales.
Potassium/sodium cation carriers robustly up-regulate CD20 antigen by targeting MYC, and synergize with anti-CD20 immunotherapies to eliminate malignant B cells
Authors: Torun Anna , Zdanowicz Aleksandra , Miazek-Zapala Nina , Zapala Piotr , Pradhan Bhaskar , Jedrzejczyk Marta , Ciechanowicz Andrzej , Pilch Zofia , Skorzynski Marcin , Słabicki Mikołaj , Rymkiewicz Grzegorz , Barankiewicz Joanna , Martines Claudio , Laurenti Luca , Struga Marta , Winiarska Magdalena , Golab Jakub , Kucia Magdalena , Ratajczak Mariusz Z. , Huczynski Adam , Calado Dinis P. , Efremov Dimitar G. , Zerrouqi Abdessamad , Pyrzynska Beata
Published: December 2024

Our investigation uncovers that nanomolar concentrations of salinomycin, monensin, nigericin, and narasin (a group of potassium/sodium cation carriers) robustly enhance surface expression of CD20 antigen in B-cell-derived tumor cells, including primary malignant cells of chronic lymphocytic leukemia and diffuse large B-cell lymphoma. Experiments in vitro, ex vivo, and animal model reveal a novel approach of combining salinomycin or monensin with therapeutic anti-CD20 monoclonal antibodies or anti-CD20 CAR-T cells, significantly improving non- Hodgkin lymphoma (NHL) therapy. The results of RNA-seq, genetic editing, and chemical inhibition delineate the molecular mechanism of CD20 upregulation, at least partially, to the downregulation of MYC, the transcriptional repressor of the MS4A1 gene encoding CD20. Our findings propose the cation carriers as compounds targeting MYC oncogene, which can be combined with anti-CD20 antibodies or adoptive cellular therapies to treat NHL and mitigate resistance, which frequently depends on the CD20 antigen loss, offering new solutions to improve patient outcomes.
Knowledge of Non-Communicable Diseases and Their Associated Modifiable Risk Factors Among the Adult Rural People at Burichang, Cumilla, Bangladesh
Authors: Hoshen Md Minuddin , Sultana Rehana , Salim Airin , Bristi Priyanka Das , Siddique Md Asraful Alam , Liza Kamrun Nahar
Published: December 2024

Background: Non-communicable diseases (NCDs) are known as chronic diseases which are rising day by day. The results, disability and early mortality, are turning out to be the major issues for global health. Exposure to NCDs risk factors has an impact on all aspects of life, making it essential for health promotion that individuals need to be aware of non-communicable diseases and their risk factors. The objectives of the study to assess the knowledge of non-communicable diseases and their associated modifiable risk factors among the adult rural people at Burichang Upazila, Cumilla, Bangladesh.
Materials and methods: The cross-sectional study was conducted from July to December 2023. A total of 309 adult people were selected by non-probability purposive sampling at Monipur village of Burichang Upazila under Cumilla Districtwith ethical clearance from respective IERB. Data was collected by face-to-face interview with a semi-structured questionnaire and checklist. Data were analyzed according to the study objective through Statistical Package for Social Science (SPSS). Informed written consent was taken before data collection and ethical issues were maintained at different stages of this study.
Results: Out of all participants, 184 (59.5%) were female and 125 (40.5%) were male, the mean (±SD) age of the participants was 38.81±14.369 years and the highest frequency 38.5% was in the 18-30 years group. Among all the participants 245 (79.3%) were married and 89 (28.8%) completed their primary education. In our study, among all the participants, 171(55.3%) had average knowledge, 99 (32.0%) had good knowledge and 39 (12.6%) had poor knowledge about non-communicable diseases. The study findings also showed that the level of knowledge about modifiable risk factors of non-communicable diseases, 170 (55.0%) had average knowledge, 111 (35.9%) had good knowledge, and 28 (9.1%) had poor knowledge.
Conclusion: It can be concluded from our study that knowledge regarding non-communicable diseases and their modifiable risk factors was not satisfactory. The results of this study demonstrated the necessity of health education and interventions to raise knowledge about non-communicable diseases and their risk factors.
Eastern Med Coll J. July 2024; 9 (2): 56-61
Russell’s Viper Phobia
Authors: Ahmed Musleh Uddin , Sultana Rehana , Karmakar Pijush
Published: December 2024

Abstract Not Available.
Eastern Med Coll J. July 2024; 9 (2): viii-xi
Effectiveness and Safety of Intracameral Ceftazidime Injection in Phacoemulsification
Authors: Islam Mohammad Ariful , Hossain Mohammad Sabbir , Alam Mohammad Nurul , Rain Md Zinnu , Mridha Md Zan E Alam , Iqbal Syed Shahin
Published: December 2024

Background: Cataract is the number one cause of blindness worldwide, which is curable with simple removal of cataractous lens and IOL implantation. But cataract surgery is complicated by postoperative infection (endophthalmitis) mainly that can lead to loss of sight or even loss of the eye. But it has been observed in some cases; with a very good and uneventful cataract surgery patient’s vision may not improve without any preexisting ocular disease. Patient as well as surgeons become tense in this aspect. In this case this is not due to infection, but some other factors are responsible for poor vision. It is speculated that intraocular tissue reaction towards the fluidics, intracameral antibiotic, efficiency of surgeon and the machine used may have contributed to this. We have tried to evaluate the ocular tissue effect with intracameral ceftazidime along with ringer’s lactate solution. However, it is also used as a prophylaxis of endophthalmitis. It is now time to demand study to evaluate safety aspects of the intracameral ceftazidime used in phacoemulsification. The objective of the study is to evaluate the safety profiles of intracameral ceftazidime in phacoemulsification.
Materials and Methods: The prospective interventional study was conducted at National Institute of Ophthalmology & Hospital, Dhaka, Bangladesh from January 2022 to June 2022 with ethical clearance from respective IERB. Sixty patients were selected and half (30) of them receive intracameral ceftazidime (1 mg in 0.1 ml) and the rest (30) of them receives ringer’s solution 0.1 ml - given intracamerally at the end of phacoemulsification. Central endothelial cell density (ECD), central corneal thickness (CCT) and central retinal thickness (CRT) were determined by specular microscopy, pachymetry and ocular coherence tomography, respectively, preoperatively, at 7th postoperative day and 3 months after surgery.
Results: This study showed no statistically significant differences in the changes of ECD, CCT and CRT between eyes receiving intracameral ceftazidime and control.
Conclusion: The use of intracameral ceftazidime (1 mg in 0.1 ml solution) at the time of phacoemulsification had no significant effect on ECD, CCT and CRT postoperatively.
Eastern Med Coll J. July 2024; 9 (2): 82-86
A Morphometric Analysis of the Right-sided Human Humerus’s Shaft and Nutrient Foramen
Authors: Siddique Md Asraful Alam , Phathan Md Azmal Khan , Karmakar Pijush , Iqram Towhidul , Hoshen Md Minuddin
Published: December 2024

Background: The term ‘morphometry’ describes the quantitative analysis of form, which includes size and shape. Additionally, it is employed in describing the shapes of various objects and in precisely locating specific locations of organs. Forensic experts and anatomists both appreciate knowing the average values of humerus segments since it aids the investigator in determining the identity of the skeleton. The nutrient foramen (NF) is important to bone formation and nutrition.
Materials andMethods: This descriptive type of study was conducted in The Department of Anatomy, Sylhet MAG Osmani Medical College, Sylhet from January to December 2021with ethical clearance from respective IERB. Two hundred (200) normal adult right humerus were collected for the study purpose. Samples were collected according to the inclusion and exclusion criteria. Study variables were maximum humeral length (cm), the circumference of the middle shaft of the humerus (mm) and the number and location of the nutrient foramen. To explore the morphometry of the humerus, measurement was evaluated by using sliding vernier calipers, measuring tape, graph paper, cardboard and measuring scales.
Results: Maximum humeral length was 30.33±2.11 cm and circumference of the middle shaft of the humerus was 0.72±0.05 mm. In this study 86% of humerus had single nutrient foramen and 14% had double nutrient foramen. Among them 88% of nutrient foramen belonged to Zone II, 7% to Zone I and 5% to Zone III.
Conclusion: The study provides morphometric data of Right-sided Human Humerus’s Shaft and Nutrient Foramen, which will be helpful to place the various implants in the reconstructive surgery of humerus fractures and helps the anthropologists & forensic experts in identifying unknown body parts of bodies.
Eastern Med Coll J. July 2024; 9 (2): 87-90
Healthcare Associate Infection in Different Departments of a Tertiary Care Hospital in Bangladesh
Authors: Farzin Anika , Goutam Arpita , Neeva Nahla Islam , Akter Kajol , Khan Md Taifur Aziz , Jahan Tarana , Hossain Md Tanvir
Published: December 2024

Background: Healthcare-associated infections (HAIs), which occur when a patient is receiving care in a hospital or other healthcare facility, are the most frequent adverse events in healthcare worldwide. This study aimed to find the causative bacterial agents of HAI from different clinical samples in different departments.
Materials &Methods: This was a cross-sectional descriptive study conducted in the department of Microbiology & Virology, Sylhet MAG Osmani Medical College, in collaboration with in-patient departments of Sylhet MAG Osmani Medical College hospital from January 2019 to December 2019with ethical clearance from respective IERB. A total of 123 patients of different age, sex was enrolled in this study. Samples were collected from postoperative wounds, post catheterized urinary tract infections, diabetic wounds and intravenous cannula from Surgery, Medicine and Obstetrics & Gynecology ward. Standard laboratory procedures were applied to isolate and identify the bacteria.
Results: Among 123 patients 46 (37.4%) were affected by hospital acquired infections. Higher prevalence (n=28, 60.87%) of HAI was found in the Surgery ward and the lower prevalence (n=9, 19.56%) was found in Medicine and Obstetrics & Gynecology ward. The difference in the frequency of growth and no growth in samples collected from these departments was almost the same. The most common type of infection was surgical wound infection (43.48%). Staphylococcus aureus (28.26%), Pseudomonas aeruginosa (17.39%) and E. coli (13.04%) were the primary causes of healthcare-associated infections.
Conclusion: Irrespective of all circumstances, HAI is a burden now-a-days for healthcare professionals. So proper knowledge about the rate of its occurrence and the reasons should be found to control its burden. Through monitoring and proper implementation of IPC can help us to control this situation.
Eastern Med Coll J. July 2024; 9 (2): 105-109
Cardiovascular risk faced by smokers and benefits of cessation of smoking
Authors: Khan Indira Sufia
Published: December 2024

Abstract not available
J Med Coll Women Hosp. 2024; 20(2):10-16
Clinicopathological profile of dengue fever among children admitted in Medical College for Women & Hospital, Dhaka, Bangladesh
Authors: Alam Mohammad Mahbubul , Khatoon Nushura , Sultana Razia , Hoque Saidul , Karim Enamul , Kumar Ghosh Susanta
Published: December 2024

Background: Dengue is not always manifested by its typical clinical features, its presentation may be atypical which may create confusion among physicians while making a diagnosis. The clinical profile that was seen in earlier epidemics has changed over time and various atypical features are found in day to day clinical practice. The trends in simple hematological and biochemical parameters are of utmost importance to evaluate the severity of the disease. Aim:This study was carried out to evaluate the clinico-pathological profile of dengue fever in children.Materials and Method: This cross-sectional study was conducted in the department of Paediatrics, of Medical College for Women and Hospital, Uttara, Dhaka, from August to October 2023 following ethical clearance of the protocol. A total of 250 children aged 0-18 years attended in the study center with fever with positive NSI  (nonstructural protein 1) antigen or positive IgM (Immunoglobulin M) antibody of dengue were included after getting informed written consent from their legal guardians. Data were collected by using a structured questionnaire. Collected data were analyzed by the SPSS 26.Result: The mean±SD of age of the respondents was 7.12±4.26 year with male predominance (54.8%). All respondents had fever, wherein majority had low grade fever (67.2%). More than half of the respondents (52.4%) had vomiting. Oral thrush (42.8%), abdominal pain (34%), congestion of the eye (28.4%), runny nose (22.4%), cough (16%), headache (15.6%), rash (14.8%), lack of appetite (14%) and loose stool (13.6%) were the other common clinical features. Pleural effusion (15.6%) in Chest X-ray and respiratory distress (28.8%) and ascites (17.6%) were other common findings. Hepatomegaly, ascites, respiratory distress, pleural effusion and edematous gallbladder were significantly more in severe dengue than non-severe dengue fever. Besides, decreased Hb% (hemoglobin %), increased HCT (hematocrit) level, SGPT (Serum Glutamic Pyruvic Transaminase) >56U/L and SGOT (Serum Glutamic Oxalo-Acetic Transaminase) >45U/L were significantly higher in severe dengue fever than non-severe dengue.Conclusion: Dengue in children presented with diverse symptoms and severity. However, further multicenter study is recommended to verify the present findings.
J Med Coll Women Hosp.2024; 20(2): 44-55
Valproic Acid induced Acute Hemorrhagic Pancreatitis with Transient Hyperglycemia in a Child with Temporal Lobe Epilepsy: A Case Report
Authors: Hasan Md Rakibul , Kumar Ghosh Susanta
Published: December 2024

Valproic acid (VPA) is a well-tolerated anti-epileptic drug. It is mainly used for the management of epilepsy, acute mania, bipolar mood disorder, and prophylactic treatment of migraine. Acute pancreatitis is a serious side effect of VPA with an incidence of 1:40,000. A higher number of cases has been reported among children and adolescents. The idiosyncratic reaction is the main cause of pancreatitis; however, a higher dose may aggravate the condition. In most cases, it usually develops on average 11 months afterVPA initiation; however, it is rarely seen before 3 months. Here we are reporting a 6-year-old boy who developed acute hemorrhagic pancreatitis within three months following initiation of VPA for management of temporal lobe epilepsy. The patient was successfully managed by conservative treatment with intensive care support. Finally, we discharged the patient with Levetiracetam and followed up without any side effects or any new episodes of seizure.
J Med Coll Women Hosp. 2024; 20(2): 72-75
The influence of complex seed inoculation on soil microflora of leguminous crops agrophytocenosis
Authors: Turina O. , Didovych S. , Kulinich R. , Didovych A.
Published: December 2024

The influence of pre-sowing treatment seeds by microbial preparations on the basis of effective heterotrophic (nodulating, growth-promoting and phosphate mobilizing microorganisms, and microorganisms-antagonists of the phytopathogenes) and phototrophic microorganisms (cyanobacteria) on changes of microbial cenoses and its functional structure (the number of the main ecological trophic groups of microorganisms, ratios of a mineralization, oliogotrophic and microbiological transformation of organic substance) and seed productivity of pea plants, peavine and lentil in the cultivation in the steppe zone of Crimea were investigated in this work. Possibility of an intensification of soil microbiological processes in the rhizosphere of the chernozem southernat different stages of ontogenesis of legumes at the expense of an introduction the heterotrophic and phototrophic microorganisms were proved. Application of polyfunctional microbial preparations affects ratios of mineralization, oliogotrophic and microbiological transformation of organic substance, but intensity of these processes was different depending on preparations. Besides, application of microbial preparations increases seed productivity of legumes by 0.2– 0.6 t/ha (29–78%) and contents of protein in seeds by of 1.7–7.1%. Studies in 2014 were financially supported by Russian Foundation for Basic Research (RFBR) and the Republic of Crimea, grant 14-4401621.
Diagnosis of seed viral infection of vegetable crops
Authors: Boyko A. , Opryshko N. , Tsvigun V. , Orlovskaya G.
Published: December 2024

The present study was designed to determine the presence of viral antigens in seeds of various cultivars of tomato (Lycopersicum еsculentum Mill.), paprika (Capsicum annuus L.), eggplant (Solanum melongena L.). Research was conducted using commercial cultivars of Solanaceae seeds of 3 firms: «Semena Ukrainy», «Flora market» and «Vesna». The results of this investigation showed that the Cucumber mosaic virus (CMV) had the highest dispersion. There were cultivars of tomato «De-Barao KrasnyY», «Yablonka Rossii», paprika «Anastasia», «Sladkiy pastuh», eggplant «Almaz». CMV was identified both in the embryo, and on the seed surface structures. Tomato mosaic virus (ToMV) was identified in seeds of paprika cultivar «Rotunda», tomato «De Barao Krasny». The impact of phytoviruses on sowing qualities of infected seeds was examined. The study found that viral infection had no impact on laboratory germination, but decreased seed vigor and germinative power. The deformation of leaves and their lag in growth were observed between infected and healthy seeds.
Classification of peat bogs in the development and typology of gelo-landscapes
Authors: Konishchuk V.
Published: December 2024

Methodological approaches for classification of peat ecosystems are justified on the basis of their origin and interaction with the environment. Regardless of using peat it is important to have a basic understanding of its characteristics, the basic characteristics that are the basis for determining the type, the kind of peat, genesis features of the current status of gelolandscapes. We grounded eco-genetic model for development of peat bogs. We systematized all types of peat deposits Polissya as lowland type including 3 subtypes, 8 groups, 29 species; transitional type — 3 subtypes, 6 groups, 11 species; saddle type — 3 subtypes, 6 groups of 19 species. For Polissya zone sub-province with mixed, coniferous and deciduous forests we identified the following four main types of peat bogs: postlimneal, postpotam, upland, anthropogenic.
Peculiarities of microelement provision in the soils of Ukraine
Authors: Yatsuk I. , Panasenko V. , Naumenko A. , Venglinskyi M. , Godynchuk N.
Published: December 2024

The results of the 9th round of agrochemical inspection of agricultural lands over the content of such microelements as manganese, copper, cobalt, zinc are given. Analysis of microelements content of soils of Ukraine is made. It was shown that the vast majority of soils of the country has heightened, high and very high content of manganese, copper and cobalt. Mobile forms of zinc are in deficiency; including 77% of inspection of the area, which have low and very low content of this element. Considerable spatial diversity of microcells in soils at all levels of the organization of the territory is observed. A necessity for carrying out agrochemical inspection of soils for ensuring effective use of microfertilizers and receiving high and qualitative crops is proved.
Peculiarities of natural zeolites as carriers of microelements in agriculture
Authors: Moklyachuk L. , Nikitina B. , Lishchuk A. , Tsyba M.
Published: December 2024

The use of natural zeolites in agriculture was explored. It was analysed the adsorption capacity of the zeolite-sokirnit (clinoptilolite) of Ukrainian deposits and investigated its ability to form the nanocomposite materials of type «guest-host.» It was established the size of micropores of zeolite by using the method of low-temperature adsorption-desorption nitrogen. As it has been shown their low values indicate on the partially filling of microporous space with natural cations. The differential curve, obtained by DFT, has a number of peaks corresponding to a multimodal distribution of mesopores in the zeolite. These pores are the main nanoscale containers for impregnating zeolite by complex ammines of essential micronutrients for long-acting fertilizers for the increase of quality of agricultural production