bluuebunny/crossref_metadata_2025 huggingface dataset:
High-speed drill craniostomy as a minimally invasive method of chronic subdural
hematoma management. Preliminary results of a pilot study
Authors: Rončević Alen , Splavski Bruno , Mužević Dario , Vekić Mužević Marina , Blagus Goran
Published: March 2023

Objectives: The objective of this study was to assess the safety and efficiency of minimally invasive high-speed drill craniostomy in the treatment of chronic subduralhematomas.Study design: The study was designed as a retrospective case series study.Patients and Methods: The patients with compressive chronic subdural hematomas were treated by minimally invasive high-speed craniostomy performed underlocal anesthesia or conscious sedation. A minimal skin incision was followed by a single high-speed drill hole placement in the frontal or parietal region, over the area of maximal hematoma thickness. After hematoma aspiration, a 1.9 mm silicone catheter was placed in subdural space and connected to gravity-assisteddrainage. Patients were ambulatory immediately after surgery. Data on clinical course and outcome were recorded and analyzed.Results: There were 23 patients (5 female, 21.7%) included in the study. The median patient age was 77.5 years (interquartile range 67 - 83). Six (26.1%) of the patients had bilateral subdural hematomas. Septated/multiloculated hematomas were observed in 6 (26.1%) patients. Heterodense hematomas denoting more recent bleeding were recorded in 16 (69.5%) patients. The median duration of subdural drainage was 4 days (interquartile range 3 to 5). The median length of hospital stay was 9.5 days (interquartile range 6 - 16). One patient died of sepsis following a nosocomial respiratory infection. One patient developed a wound infection with subdural empyema, requiring subsequent craniotomy. One patient had deep venous thrombosis and pulmonary embolism. In all patients, postoperative CT scans showed a significant reduction of hematoma volume and midline shifting. No postoperative seizures were observed.Conclusion: High-speed drill craniostomy is a safe, simple, straightforward, and effective treatment for the management of chronic subdural hematomas, including multiloculated and heterodense lesions. Elderly patients could most benefit from such a procedure, avoiding general anesthesia, prolonged intracranial procedures, and lengthy hospital stays.
The Local Online Media Professionalism Over Candidate Framing Inside Pacitan Election 2020
Authors: Hendriyanto Agoes , Purwasito Andrik , Rais Wakit Abdullah , Hastjarjo Sri
Published: March 2023

The Pacitan Local Leaders Election (Pilkada Pacitan) 2020 must both run democratically and prioritize the citizens’ health in the time of the Covid-19 pandemic. Besides, Pacitan local online media are firstly allowed under regulations (PKPU No 13, 2020) to achieve the success of the elections. From this first-time involvement, the local online media are dealt with various interests trying to attract journalists or online media to stand with one or the other candidate pairs. To meet the purpose, the researchers employed qualitative research methods using framing analysis. In this case, Edelman framing analysis, with categorization choice by highlighting and eliminating other aspects, aims at building an opinion. In conformity with the results, the local online media are not neutral. Further, the news text framing of the online media professionalism in reporting the Pacitan Pilkada was as follows: 1) political culture in Pacitan, 2) ethical competence, 3) legal competence, 4) knowledge competence. Those competencies must be possessed by a journalist. Even more, they were carrying out political activities such as the 2020 Pilkada. The professionalism of journalists was necessarily needed, especially in Indonesia’s democratic party implementation to elect legislative and executive leaders who were truly coming from the people’s soul.
Participatory Development Communication for Family Food Security during the Covid-19 Pandemic
Authors: Egiwirantia Enggar Dwiki , Destrity Nia Ashton
Published: March 2023

The objective of this study is to elaborate and assess participatory development communication strategies employed in women's empowerment program by an Islamic non-governmental organization, specifically Lembaga Lingkungan Hidup dan Penanggulangan Bencana (LLHPB) 'Aisyiyah (Environment and Disaster Management Institute) Probolinggo City, East Java, Indonesia in 2020 to attain family food security during the Covid-19 pandemic. The three series of activities that constitute this empowerment program include training on planting vegetables, training on vegetables and fish cultivation in buckets, and engaging the online 'Aisyiyah Market group. This study utilized a case study methodology, collecting data through documentation and interviews with six informants who were committee members and members of 'Aisyiyah who are active in the empowerment initiative. This study demonstrates that, generally, the circumstance that the committee retains complete authority during crucial decision-making phases contributes to the practice of participatory communication in empowerment program. According to this study, the three activities used monologic and dialogic communication modalities in varying methods. Because collaborative member involvement only occurs when planning the formation of the 'Aisyiyah Market group, the level of member participation in the other two activities is still at a low level and only reveals involvement at the implementation and post-implementation stages of the activity.
The Impacts of “A Plastic Ocean” Film on The Environmental Care Attitudes of Senior High School Students in Tangerang
Authors: Mansur Suraya , Saragih Nurhayani , Mijan Rohana Binti
Published: March 2023

This research examines the impacts of “A Plastic Ocean” film on the environmental care attitudes of Senior High School students at SMAN 2 Tangerang. This research proves that the social learning theory is effective to promote a campaign with film, which results in behavioral changes in society. The theory used in this research is Albert Bandura's social learning theory. This research utilized the positivistic paradigm. This research employed a survey explanatory method and quantitative approach. The population was Senior High school Students at SMAN 2 Tangerang. The sampling utilize a purposive sampling technique to 100 respondents, with a sampling error of 5%. The technique of data analysis utilized a simple regression analysis. The hypothesis how that there is no influence between the content of the “A Plastic Ocean” film on environmental care attitudes on students. High school students are interested in the film, while the attitude of caring for the environment is not influenced by the film.
Campaigning Zakat on Social Media: The Role of Message Strategies in the Decision to Pay Zakat
Authors: Nasution Juliana , Nurhayati Nurhayati , Marliyah Marliyah
Published: March 2023

Zakat campaigns in Indonesia have utilized social media as a platform to address various zakat management problems. This research examines the message strategies used by zakat institutions in their campaigns on social media. Messages are an important component in the success of a campaign to influence the voluntary behavior of campaign targets. The message strategy theory applied in this study refers to Tafesse and Wien, including informational, transformational, and interactional messages. This research uses a quantitative approach, employing muzakki zakat in Dompet Dhuafa Waspada, North Sumatra, as the respondents. Data analysis technique used the SEM-PLS approach with SmartPLS 4.0 software. The research results show that the informational and transformational variables had a significant effect on the decision to pay zakat. Meanwhile, the interactional variables had no significant effect on the decision to pay zakat. Therefore, the role of message strategy in zakat campaigns on social media is important to increase zakat fundraising.
Necessary and Sufficient Conditions for Constant Prices in a Sraffa’s Model
Authors: Giorgi Giorgio
Published: March 2023

We give a simple and direct proof of necessary and sufficient conditions to have constant equilibrium prices in a simple Sraffa’s production model. We make some remarks on the linearity of the relation between profit rate and wage rate.
O dever de fundamentação das decisões judiciais e o Artigo 489 §1º, do CPC: rupturas, continuidades ou resistências?
Authors: Gomes Lupetti Baptista Bárbara , Navarro Puerari Daniel
Published: March 2023

Este trabalho pretende descrever e problematizar, desde uma perspectiva empírica, se é como o §1º do artigo 489 do CPC está, ou não, sendo implementado em nosso sistema de justiça. A hipótese da pesquisa partiu de uma dúvida (ou estranhamento), no sentido de que, embora o CPC de 2015 tenha traçado parâmetros objetivos para delimitar o conceito de “decisão fundamentada”, a efetiva concretização desse novo dispositivo, no contexto processual brasileiro, tende a sofrer resistências, especialmente da magistratura, na medida em que impõe deveres e regramentos rígidos, com potencial de restrição à autonomia do poder de decisão judicial. De forma incipiente, e sem pretender generalizar os resultados da pesquisa, verificamos, através de entrevistas formais e informais com 15 (quinze) magistrados do TJERJ, que, de fato, a nova redação do artigo 489, parágrafo 1º, do CPC, vem se apresentando como uma proposta de ruptura que confronta a estrutura sedimentada do sistema processual brasileiro, revelando-se, o referido dispositivo, como um obstáculo ou, pelo menos, um desafio, no campo prático do Direito. Porém, mais do que em nome da liberdade de decidir, surpreendentemente, as falas dos entrevistados revelaram que a meta da celeridade processual é um dos principais obstáculos ao dever de fundamentação, porque seria “impossível ser célere e cumprir o artigo 489 ao mesmo tempo”.
Wealth or Just Job Seekers: Medieval Skeletal Series from Kutná Hora-Sedlec (Czech Republic) with a Notable Surplus of Men
Authors:   Institute of Archaeology of the Czech Academy of Sciences, Letenská 4, 118 01 Prague 1, Czech Republic, Brzobohatá Hana , Frolík Jan ,   Institute of Archaeology of the Czech Academy of Sciences, Letenská 4, 118 01 Prague 1, Czech Republic, Velímský Filip ,   Institute of Archaeology of the Czech Academy of Sciences, Letenská 4, 118 01 Prague 1, Czech Republic
Published: March 2023

Kutná Hora entered the 14th century as a rich, prosperous, and densely-populated city producing tons of silver. Such an amount of precious metal could not be mined and processed without an influx of people from other cities and rural areas and without the contribution of skilled specialists from abroad. Despite the apparent wealth of the city, its inhabitants (either settled or newly arrived) experienced and died during mortality crises. Evidence of such events was discovered in the Kutná Hora suburbs, where the medieval burial ground, including a significant component of mass burials, has been unearthed. In the data derived from pooled catastrophic and non-catastrophic burials (n=1785 individuals), a notable surplus of males has been identified with a striking imbalanced adult sex ratio of 149. After considering factors potentially influencing this value, we suggest that the figure likely mirrors the original population composition as a consequence of the inflow of men migrating to the town for labour/economic opportunities.
Occurrence of the red-leaved rose Rosa glauca Pourr. (Rosaceae), in Poland
Authors: Sołtys-Lelek Anna , Gruszka Wojciech
Published: March 2023

The red-leaved rose, Rosa glauca, has the status of an established, non-invasive kenophyte species in Poland. In the 1970s, it was reported to be commonly cultivated, and since the second half of the 20th century, information about its spontaneous spread, mainly in the western part of the country, has appeared in the literature. The aim of this study was to present the current distribution of Rosa glauca sites in Poland. The possible invasive potential of this species was also studied.
Revision of the genus Daldinia in the KRAM herbarium collection: Daldinia childiae, D. loculata and D. loculatoides, three new species for Poland
Authors: Chlebicki Andrzej
Published: March 2023

The article presents the results of the revision of Daldinia (Ascomycota) specimens preserved in KRAM F (Kraków, Poland). The following species were identified: Daldinia childiae, D. decipiens, D. loculata, D. loculatoides, D. petriniae and D. vernicosa. Three of them were not reported from Poland so far: D. childiae, D. loculata, D. loculatoides. Aditionaly to Polish specimens, also some collections from outside Poland are kept in KRAM F: one specimen of D. concentrica from Bulgaria, D. lloydii from Ukraine and D. eschscholtzii from Cameroon.
Allelopathic effect of Ulva intestinalis thallus on selected Baltic cyanobacteria
Authors: Budzałek Gracjana , Śliwińska-Wilczewska Sylwia
Published: March 2023

Macroalgae have been found to produce active allelochemicals that inhibit of growth other organisms that compete with them for light and space. However, their allelopathic activity on Baltic cyanobacteria is still insufficiently recognised. Therefore, this study aimed to demonstrate the allelopathic effects of Baltic macroalga thallus (Ulva intestinalis) on the growth and photosynthetic activity of three bloom-forming cyanobacteria: Aphanizomenon sp., Nodularia spumigena, and Nostoc sp. This study investigated the cell count of the analysed cyanobacteria (N 105 mL-1), the maximum quantum yield of the second photosystem (PSII) in the dark (Fv/Fm), and the real quantum yield of PSII in the light (ΦPSII) (in the control and the experiments). After 7 days of exposure, the following were added: 0.01, 0.05, and 0.1 g mL-1 of U. intestinalis fresh thallus. It was found that thallus obtained from U. intestinalis had no statistically significant effect on the number of cells of the cyanobacterium Aphanizomenon sp. (at 0.05 and 0.1 g mL-1) and Nostoc sp. (at concentrations of 0.01 and 0.05 g mL−1). On the other hand, it was examined a stimulating effect of 0.01 g mL-1 of the fresh thallus on the number of Aphanizomenon sp. cells which constituted 168%, relative to the control. It was shown that the fresh thallus addition resulted in a decrease in the number of N. spumigena cells (45%, 27%, and 46% after addition of 0.01, 0.05, and 0.1 g wet weight mL−1 of fresh thallus, respectively). In experiments with Nostoc sp., the addition of U. intestinalis thallus has been a negative effect on cyanobacterial growth at 0.1 g mL−1 and constituted 97% of control. It was also found, that U. intestinalis had no allelopathic effect on fluorescence parameters of N. spumigena. All tested concentrations of thallus U. intestinalis (0.01, 0.05, and 0.1 g wet weight mL-1) stimulated the values of Fv/Fm or ΦPSII of cyanobacteria Aphanizomenon sp. and Nostoc sp. compared to the control. These studies help define the role of U. intestinalis allelopathy as a biological factor in the distribution of bloom-forming cyanobacteria in the coastal Baltic Sea region.
Fire influence upon the savanna vegetation in Zambia and problems related with the role of this factor
Authors: Medwecka-Kornaś Anna
Published: March 2023

The observations, lasting above one year, have concerned particular plant species and plant communities on two selected savanna plots burned earlier, situated near Lusaka, and additionally some other localities. After the opening remarks, some information about fire’s influence on vegetation is given, with a quotation of papers connected with the area of investigations, as well as the author’s and Jan Kornaś’s publications. Those texts are followed by a short description of the geographical conditions in the region taken into account, of the studied plots, and information about the methods of investigations. Subsequently, there is a list of noticed species, with short descriptions and some pictures. Phytosociological data are presented in tables. The following chapters contain the joint characteristic of the studied vegetation: data about its floristic composition, phenology, and morphology of species. The Raunkiaer’s plant classification is considered here; afterward data on the water content in some roots and rhizomes are presented. The next chapter contains the description of common features of vegetation on the studied plots. Thereafter may be found information about the pyrophytic plant species noticed elsewhere in Zambia. In the discussion publications supplementing the author’s study are mentioned. Further, more detailed descriptions of the features of fire, its occurrence in nature, distribution, and structure of savannas are included. Plant regeneration on the burned plots, the usefulness of Raunkiaer’s classification in the tropics, and problems of evolution of pyrophytes are presented. There is also some evidence of phytosociological studies in Africa and proposals for the establishment of a new association Hyparrhenio-Gardenietum. In the end, some conceptions concerning the rational use of fire, particularly in nature conservation, are mentioned, as well as arguments for the protection of pyrophytic species.
Cuando a mi puerta llegas
Authors: Guerrero Collazos Adela
Published: March 2023

Con la seguridad de entrar en un reino y una escritura diferentes, me sumerjo en la poesía de Adela Guerrero Collazos, y no encuentro un sólo verso que logre dejarme sumida en la desolación o en la total indiferencia, o en ese extraño vacío de las confrontaciones facilistas. A la poeta hay que leerla para recibir su parábola de amor, para sentir su relación con lo absoluto. Como el hada que habita lo fundamental, la poesía es la esencia que alimenta el poema, la que poetiza su letanía, la que convoca a su Dios a permanecer en ella. Y no es su poesía una lección moralista o una tentativa religiosa o de dioses falsos, es una conjugación de cosmogonías y fuerzas excepcionales. Poesía que la nombra como una voz independiente y plena, gestada en su contacto con la tierra, con su eco y su camino, y sus ríos largos como la historia del mundo. Unida a ese misterio que somos, a su célula más vívida, la poeta hace su plegaria diariamente, poema que es respiración y la sostiene, que es voz y la alienta.
La saga de los clavellinos
Authors: Franco Zambrano Alvaro Neil
Published: March 2023

La verdad de la poesía que no crea un mundo imaginario sino que celebra el existente, las palabras de Neruda pidiendo con convicción el ser liberado de inventar, la rotundad materia de las palabra elevada a la naturaleza de seres que respiran y habitan un mundo contemplado con amor, forman parte del espíritu que anima estos poemas de Álvaro Neil Franco Zambrano. Sus versos nos regalan el paisaje de su infancia y juventud inocentes, afectuosas, marcadas por el amor a los hombres, y celebran con cariño y verdad días luminosos y encarnados en un corazón que nos va dando su porción de tiempo sin jamás detenerse en mezquindades. La familia, los amigos, las mujeres, atraviesan estas páginas y nos dejan con una sonrisa, con una sensación de vida y esperanza, de fiesta dichosa.
Institutional Arrangements and Processes Rotation of Assets of Defense Industry Corporation
Authors: Musatova M. M.
Published: March 2023

The article assesses the place and role of institutional design in the processes of consolidation and restructuring of the assets of defense industry companies (defense industry complex), discusses the possibility of adjusting measures aimed at activating the activities of defense companies in the context of growing geopolitical tensions, forms and methods of effective institutional management of the process of modernization of the main economic entities of the defense industry: Rostec State Corporation, Roscosmos State Corporation, United Shipbuilding Corporation (USC), etc. Its scientific novelty consists in the development of a comprehensive view of the institutional design of the processes of consolidation and rotation of the assets of defense companies in the context of the ongoing sanctions regime. Among the directions of changes in the institutional structure for the development of defense companies are analyzed: the creation and dissemination of common requirements (universality and compatibility) to the processes of design and production of products; the emergence of new leasing programs for technological equipment for various industries with preferential treatment; improving the system of publicprivate partnership (PPP) in certain dominant areas of development (microelectronics, IT-technologies); participation of defense industry companies in investment projects in special economic zones (SEZ) and territories of advanced development (TOP); localization of production within the framework of import substitution; updated approaches to the financial recovery of defense industry enterprises against the background of the preparation of large-scale changes to the bankruptcy law; maintaining a favorable institutional background in the M&A market for defense enterprises, etc.
On the Relationship between Health Capital and Economic Growth in Russian Regions (2013–2018)
Authors: Kaneva M. A. , Untura G. A.
Published: March 2023

Over the last few years in the Russian economy and politics, it was generally agreed that the population’s health is one of the drivers of the economic growth. While little research has been done on the relationship between health capital, health care costs and economic growth, there is no generally accepted model in economic theory supported by empirical tests for individual countries and regions that would explain the relationship between these variables. This study aims to address this gap and quantifying the impact of health capital and health care costs on the regional economic growth in 2013–2018 within the economic growth model with endogenous technological progress. The authors constructed two specifications of the Arellano-Bond model for the dependent variable GRP per capita growth rate. The simulation results have made it possible to conclude that the accumulation of health capital leads to increased economic growth in the Russian regions. Simultaneously, an increase in government spending on health care at a fixed level of health capital did not result in an increase in GRP per capita growth rate in 2013–2018, which a number of factors can explain, i.e. general focus of public health expenditure on maintaining a favorable epidemiological situation and infrastructure of industries not directly related to individual health as well as possible insufficient level of human capital accumulation in the regions. Further research will focus on assessing the impact of health capital and health care costs in an extended model to include the level of human capital.
Uneven Development of Spatial Economy of the Russian Federation and Differentiation of Growth Factors
Authors: Ibragimov N. M. , Dushenin A. I.
Published: March 2023

The article discusses the problems of spatial development of the Russian Federation, analyzes the causes and trends of changes in the spatial structure of macroeconomic indicators by federal districts in the period 2008–2015 which witnessed the cyclical nature of economic development in Russia, and assesses the factors of regional growth for the period under consideration and the potential for further development of the Russian federal districts.

The research focuses on the economy of the Russian federal districts in the period 2008–2015 characterized by the cyclical nature of the development of the Russian economy. On analyzing the periods of recession alone, it is almost impossible to obtain detailed information about the factors of economic growth. At the same time, analyzing merely the periods of growth does not take into account the possibilities of crises and their consequences. For a more detailed analysis, the time boundaries of the study were divided into three periods 2008–2010, 2010–2013 and 2013–2015.

The work is aimed at analyzing the changes in the structures of macroeconomic indicators of the Russian Federation by federal districts in the period 2008–2015, determining the reasons and tendencies of their changes, studying the factors of regional growth in 2008–2015, and assessing the potential for further development of the regions of the Russian Federation. 

The research toolkit includes the methods for analyzing structural changes as well as the methods of logarithmic and proportional division. The analysis of structural changes was used both when considering GRP growth rate at constant prices and when studying the factors of growth at total labor productivity. Logarithmic division was used when dividing the yield rises by the rises of each of the factors (e.g. decomposition of GRP rises in current prices). Proportional division was used to assess the impact of regional industries on economic growth as a whole.
Currency pluralism in Asia in the Period of the Corona-Crisis
Authors: Zharikov M. V.
Published: March 2023

The growing interest in this topic is partly a result of the increasing attention that countries are turning to sovereign monetary systems, payment systems and e-settlements due to international sanctions towards Russia and some Asian countries as well as the necessity to overcome the negative impacts of the COVID-19 crisis. The research focuses on regional and international monetary relations and is aimed at creating hedging mechanisms of financial risks and decreasing volatility of exchange rates to stabilize both balance of trade and current-account balance. The paper investigates the approaches to diversify currency risks of the countries subject to various sanctions and accompanied by the COVID-19 crisis by means of an increasing use of national currencies in cross-border transactions within the regions. The objective of the research is to develop recommendations for Asian and Russian fiscal and monetary policy authorities and central banks in the form of analytical materials that would systemize the operations of the national currencies’ offshore markets. The practical significance of the paper is the opportunities provided by an increasing use of the leading Asian and Russian currencies to incentivize the bypass channels of incoming capital, evading international sanctions and overcoming the COVID-19 crisis. The theoretical relevance of the study is to enrich the toolkit of offshore national forwards for stabilizing exchange rate policy in the context of the COVID-19 crisis. The findings and conclusions bring new insights into the role of offshore markets which allow the sanctioned countries to solve their current problems and overcome the COVID-19 crisis based on the growing pluralism of the world monetary system.
Conhecimento de acadêmicos da área da saúde e do público leigo sobre a atuação do cirurgião buco-maxilo-facial
Authors: Flamini Filho Renato , Souza Vitor de Souza e , Sombra Gesom Avohai Dias , Moura Andrezza Lauria de
Published: March 2023

Objetivo: Avaliar o nível de conhecimento do público leigo e acadêmicos de Odontologia, Medicina, Fisioterapia e Enfermagem da Universidade Federal do Amazonas sobre a atuação do Cirurgião buco-maxilo-facial. Métodos: Trata-se de um estudo epidemiológico observacional, transversal, com abordagem quantitativa, através do uso de questionários autoaplicáveis, de maneira presencial e on-line, confeccionados pelos próprios pesquisadores. Após a coleta e tabulação dos questionários em um banco de dados, foram aplicados métodos de análise descritiva, com cálculo das frequências e medidas de posição e variabilidade para verificar a diferença entre as proporções. Resultados: O público leigo e os acadêmicos do curso de Enfermagem foram classificados com um nível de conhecimento ruim sobre a especialidade, os alunos de Fisioterapia e de Odontologia apresentaram um conhecimento regular e os acadêmicos de Medicina apresentaram um bom nível de conhecimento. Conclusão: Há necessidade de maior divulgação acerca da especialidade para o público leigo e principalmente para o público acadêmico, que futuramente exercerá a profissão e terá atuação ativa nos encaminhamentos de pacientes entre os colegas da área da saúde.
Brinquedo terapêutico e o brincar: a compreensão a partir do acadêmico de enfermagem
Authors: Nova Pedro Vitor Rocha Vila , Parente Andressa Tavares , Fonseca Andressa Fabiana Ferreira , Silva Glauciane Gomes da , Paranhos Sheila Barbosa , Castro Nádile Juliane Costa de , Rodrigues Diego Pereira , Miranda Amanda Loyse da Costa , Silva Brenda Caroline Martins da , Freitas Wanne Leticia Santos
Published: March 2023

Objetivo: Compreender a importância do brincar e do Brinquedo Terapêutico no cuidado pediátrico da criança hospitalizada a partir da visão de acadêmicos de enfermagem. Métodos: Trata-se de um estudo descritivo-exploratório, com abordagem qualitativa. Participaram do estudo 13 acadêmicos de enfermagem, regularmente matriculados na faculdade de enfermagem da Universidade Federal do Pará. A coleta de dados foi realizada através de entrevista semiestruturada, os dados foram interpretados através da análise de conteúdo de Bardin, com o auxílio do software Iramuteq, com aproveitamento de 73,53% do corpus textual. Resultados: Emergiram a partir da fala dos acadêmicos quatro categorias que contextualizaram o BT no processo de hospitalização pediátrica, de ligação com a equipe e na formação profissional. A maioria dos participantes era do sexo feminino (oito), com a média de idade de 22 anos. Considerações finais: Os acadêmicos definiram a importância do Brinquedo Terapêutico através de seus benefícios na assistência de enfermagem à saúde da criança. Porém, sinalizam os desafios de sua aplicabilidade pela equipe assistencial.
Complications of PCI and its Management
Authors: Mahilmaran Asha
Published: March 2023

Contemporary percutaneous coronary intervention (PCI) has few complications and enhanced safety on one hand and on the other hand, available modern tools have enabled interventional cardiologists to venture into more complex patient subsets and fresh challenges in tackling the ensuing newer complications. Individual operators may take several years of experience before being exposed to the complications and hence, it is important to learn from the collective experience on the detection and management of these complications and better equipped to handle them when the need arises. The complications of PCI can be access related or coronary intervention related. The common acute coronary complications include abrupt vessel closure, thrombus, slow flow, dissection, perforation, stent dislodgement, and guidewire fracture and embolization. The chronic complications include late stent thrombosis, in-stent restenosis, and aneurysm formation. The use of imaging, physiology, and plaque modification tools are associated with specific complications which need to be kept in mind while using them. The successful management of complications needs prompt recognition, involving help from others and continued team effort and vigilance.
Predictors of Post-catheterization Femoral Artery Pseudoaneurysm
Authors: Rajashekhar Sama , Kumar Achukatla
Published: March 2023

Objectives:

To compare the affected patients with the age- and sex-matched patients in the control group.

Materials and Methods:

All patients who had undergone PCI, left heart catheterization, or coronary angiography between July and November 2022 were prospectively recruited. We included 247 patients in our study who underwent cardiac catheterization via femoral access.

Results:

The incidence of FAP after a diagnostic catheterization was 5.97% and 8.69% after an interventional procedure. The mean age of the patients with FAP was 54.06 ± 15.04 years and 62.5% patients were females in the affected group. In FAP group, 14 patients (87.5%) had hypertension, 8 patients (50%) had diabetes, and 37.5% were had obesity. The systolic blood pressure was 145.38 ± 29.99 mmHg, while the diastolic blood pressure was 86 ± 14.59 mmHg. Data obtained from computed tomography scanning showed that the arterial wall of the CFA was healthy in 11 patients (68.5%), while diffuse atherosclerosis was detected in 5 (31.5%) patients. In 69% of the patients, FAPs were connected to the CFA and in 31% patients to the superficial femoral artery (SFA). In 38% (6) patients partial thrombosis of the pseudoaneurysm sac observed.

Conclusion:

FAP is a common vascular complication after a diagnostic procedure or percutaneous cardiac catheterization, and its prevalence is likely to rise.
Aesthetics and style of Arvo Pärt’s work: revolution or evolution?
Authors: Савенко С.И.
Published: March 2023

Статья посвящена ключевой особенности творческой эволюции известного современного композитора, которая заключается в резкой смене стилистической парадигмы, произошедшей в середине 1970-х годов: авангардный тип письма, характерный для Пярта в 1960-е годы, уступил место стилю tintinnabuli (термин композитора), ориентированному на благозвучие в условиях литургических жанров.

The article is devoted to the key features of the creative evolution of the famous contemporary composer, which consists in the abrupt change of the stylistic paradigm that occurred in the mid 1970s: the avant-garde type of writing characteristic of Pärt in the 1960s gave way to the tintinnabuli (term of the composer) focused on euphony and liturgical genres.
A Fluctuating Density Energy Model for RNA Nucleobase Interactions
Authors: Myers Christopher , Chen Alan
Published: March 2023

A new potential termed the Fluctuating Density (FD) model is presented as an alternative to traditional fixed partial-charge force fields for describing RNA nucleobase interactions within a molecular mechanics framework. Instead of atom-centered point charges, we take inspiration from fluctuating charge models and use a site-centered density representation for electron distributions to account for charge penetration effects present in both frozen and polarizable electrostatic interactions. A parameterization procedure is established to fit the FD model against energy decomposition analysis (EDA) for density functional theory (DFT) computations of both hydrogen-bonded and stacked RNA base pairs. Additionally, the FD model's ability to replicate intermolecular interactions of NMR resolved base pairs from the RSCB Protein Data Bank, as well as a comparison against the CHARMM Drude oscillator and AMOEBA force fields, is also presented. We find that charge penetration effects, when used as a cornerstone for parameterization, have strong influences on the remaining force field energy terms such as polarization and charge transfer. Furthermore, the FD model is able to produce polarization energetic contributions from electron density changes of similar magnitude as predicted by DFT computations.
Silica particles convert thiol-containing molecules to disulfides
Authors: Li Yangjie , Kolasinski Kurt W. , Zare Richard N.
Published: March 2023

Synthetic amorphous silica is a common food additive and a popular cosmetic ingredient. Mesoporous silica nanoparticles are also widely studied for their potential use in drug delivery and imaging applications because of their unique properties, such as tunable pore sizes, large surfaces areas, and assumed biocompatibility. Such a nanomaterial, when consisting of pure silicon dioxide, is generally considered to be inert, but in this study, we showed that oxidation yields for different compounds were facilitated by simply incubating aqueous solutions with pure silica particles in the dark. Three thiol-containing molecules, L-cysteine, glutathione, and D-penicillamine, were studied separately, and it was found that more than 95% of oxidation happened after incubating any of these compounds with mesoporous silica nanoparticles in the dark for a day at room temperature. Oxidation increased over incubation time and more oxidation was found for particles having larger surface areas. For nonporous silica nanoparticles, yields of oxidation were different based on structures of molecules, correlating with steric hindrance while accessing surfaces. We propose that the silyloxy radical on silica surfaces is what facilitates oxidation. Density functional theory calculations were conducted for total energy changes for reactions between different aqueous species and silicon dioxide surfaces. These calculations identified two most plausible pathways of lowest energy to generate SiO• radicals from water radical cations and •OH radicals, previously known to exist at water interfaces.
Polarizing agents beyond pentacene for efficient triplet dynamic nuclear polarization in glass matrices
Authors: Sakamoto Keita , Hamachi Tomoyuki , Miyokawa Katsuki , Tateishi Kenichiro , Uesaka Tomohiro , Kurashige Yuki , Yanai Nobuhiro
Published: March 2023

Triplet dynamic nuclear polarization (triplet-DNP) is a technique that can obtain high nuclear polarization under moderate conditions. However, in order to obtain practically useful polarization, large single crystals doped with a polarizing agent must be strictly oriented with respect to the magnetic field to sharpen the electron spin resonance (ESR) spectra, which is a fatal problem that prevents its application to truly useful biomolecular targets. Instead of this conventional physical approach of controlling crystal orientation, here, we propose a chemical approach, i.e., molecular design of polarizing agents; pentacene molecules, the most typical triplet-DNP polarizing agent, are modified so as to make the triplet electron distribution wider and more isotropic without loss of the triplet polarization. In fact, the modification of pentacene with thiophene moieties makes the ESR spectrum sharper and stronger than that of pentacene. To elucidate the effect of the substitutions on spin polarization and zero-field splitting parameters, which determine ESR spectrum, state-of-the-art quantum chemical calculations were performed and revealed that the direction of the spin polarization is altered by the modification with thiophene moieties and the size of D and E parameters are reduced from parent pentacene due to the partial delocalization of spin densities on the thiophene moieties. The triplet-DNP with the new polarizing agent successfully exceeds the previous highest 1H polarization of glassy materials by a factor of 5. This demonstrates the feasibility of a polarizing agent that can surpass pentacene, the best polarizing agent for more than 30 years since triplet-DNP was first reported, in the unoriented state. This work provides a pathway toward practically useful high nuclear polarization of various biomolecules by triplet-DNP.
A scalable crystal representation for reverse engineering of novel inorganic materials using deep generative models
Authors: Bajpai Rochan , Shukla Atharva , Kumar Janish , Tewari Abhishek
Published: March 2023

The efficient search for crystals with targeted properties is a significant challenge in materials discovery. The rapidly growing field of materials informatics has so far primarily focused on the application of AI/ML models to predict the properties of known crystals from their fundamental and derived properties as descriptors. In the last few years, deep learning-based approaches have spawned a slew of innovative data-driven materials research applications. Materials scientists have used these techniques for the reverse engineering of crystal structures for target applications. However, one of the challenges has been the representation of the crystal structures in the machine readable format. Proposed representations in the literature lack in generality and scalability. In this paper, we train a conditional variational autoencoder with a scalable and invertible representation along with the elemental properties of the constituents as descriptors to inverse-design new crystal structures with specified attributes. When targeting formation energy, we show that our model predicts structures that are not in the complete OQMD database. Finally, we use first-principles density functional theory calculations to validate our findings and show that the developed model is able to generate novel crystal structures for targeted property, i.e. formation energy in this case.
In Silico Demonstration of Fast Anhydrous Proton Conduction on Graphanol
Authors: Achar Siddarth , Bernasconi Leonardo , DeMaio Ruby , Howard Katlyn , Johnson J. Karl
Published: March 2023

Development of new materials capable of conducting protons in the absence of water is crucial for improving the performance, reducing the cost, and extending the operating conditions for proton exchange membrane fuel cells. We present detailed atomistic simulations showing that graphanol (hydroxylated graphane) will conduct protons anhydrously with very low diffusion barriers. We developed a deep learning potential (DP) for graphanol that has near-density functional theory accuracy, but requires a very small fraction of the computational cost. We used our DP to calculate proton self-diffusion coefficients as a function of temperature, to estimate the overall barrier to proton diffusion, and to characterize the impact of thermal fluctuations as a function of system size. We propose and test a detailed mechanism for proton conduction on the surface of graphanol. We show that protons can rapidly hop along Grotthuss chains containing several hydroxyl groups aligned such that hydrogen bonds allow for conduction of protons forward and backward along the chain without hydroxyl group rotation. Long-range proton transport only takes place as new Grotthuss chains are formed by rotation of one or more hydroxyl groups in the chain. Thus, the overall diffusion barrier consists of a convolution of the intrinsic proton hopping barrier and the intrinsic hydroxyl rotation barrier. Our results provide a set of design rules for developing new anhydrous proton conducting membranes with even lower diffusion barriers.
Dual-Hydrogen-Bond Donor and Brønsted Acid Co-Catalysis Enables Highly Enantioselective Protio-Semipinacol Rearrangement Reactions
Authors: Blackburn Melanie , Wagen Corin , Bodrogean Raul , Tadross Pamela , Bendelsmith Andrew , Kutateladze Dennis , Jacobsen Eric
Published: March 2023

A catalytic protio-semipinacol ring-expansion reaction has been developed for the highly enantioselective conversion of ter-tiary vinyl cyclopropanols into cyclobutanone products bearing alpha-quaternary stereogenic centers. The method relies on the co-catalytic effect of a chiral dual-hydrogen-bond donor (HBD) with hydrogen chloride. Experimental and computational evidence is provided for a stepwise mechanism proceeding through an enantiodetermining, HBD-promoted protonation of the alkene to generate a discrete carbocationic intermediate. This short-lived (20 ps), high-energy carbocation is generated in a chiral conformation in the presence of HBD catalyst and undergoes subsequent stereospecific C–C bond migration to the enantioenriched product. This research applies strong acid/chiral HBD co-catalysis to weakly basic olefinic substrates and lays the foundation for further investigations of enantioselective reactions involving high-energy cationic intermediates.
Characterisation of the OTU domain deubiquitinase complement ofToxoplasma gondii
Authors: Wilde Mary-Louise , Ruparel Ushma , Klemm Theresa , Lee V Vern , Calleja Dale J , Komander David , Tonkin Christopher J
Published: March 2023

The phylum Apicomplexa contains several parasitic species of medical and agricultural importance. The ubiquitination machinery remains, for the most part, uncharacterised in apicomplexan parasites, despite the important roles that it plays in eukaryotic biology. Bioinformatic analysis of the ubiquitination machinery in apicomplexan parasites revealed an expanded ovarian tumour domain–containing (OTU) deubiquitinase (DUB) family inToxoplasma, potentially reflecting functional importance in apicomplexan parasites. This study presents comprehensive characterisation ofToxoplasmaOTU DUBs. AlphaFold-guided structural analysis not only confirmed functional orthologues found across eukaryotes, but also identified apicomplexan-specific enzymes, subsequently enabling discovery of a cryptic OTU DUB inPlasmodiumspecies. Comprehensive biochemical characterisation of 11ToxoplasmaOTU DUBs revealed activity against ubiquitin- and NEDD8-based substrates and revealed ubiquitin linkage preferences for Lys6-, Lys11-, Lys48-, and Lys63-linked chain types. We show that accessory domains inToxoplasmaOTU DUBs impose linkage preferences, and in case of apicomplexan-specific TgOTU9, we discover a cryptic ubiquitin-binding domain that is essential for TgOTU9 activity. Using the auxin-inducible degron (AID) to generate knockdown parasite lines, TgOTUD6B was found to be important forToxoplasmagrowth.
Prácticas docentes y saber pedagógico en contextos universitarios : propuestas para la reflexión
Authors: Pabón Meneses Carlos Alberto , Hernández Vargas Elizabeth , Londoño Ocampo León Paolo , Guerrero Luna Rosa Marcela , Mosquera Tapiero Mileida
Published: March 2023

El presente libro trata sobre la práctica docente y el saber pedagógico en profesores niversitarios. En tres capítulos, se presentan los resultados de igual número de investigaciones: “Las prácticas docentes como escenarios de saber pedagógico en profesores universitarios”, “El aprendizaje por proyectos como estrategia pedagógica en el aula”, y “La escritura académica de los profesores universitarios: en búsqueda de la mejora en la práctica docente”. En estos trabajos investigativos se resalta la característica principal del saber pedagógico, la de ser un conocimiento construido en el interior del sujeto a partir de la vida y los valores personales, del ejercicio profesional, la experiencia de educar y la reflexión contextualizada. Este saber es personal, práctico y reflexivo, y es el resultado de la práctica docente.
Peer Scaffolding among Primary ESL Learners’ Writing Task: Learners’ Behaviors and Triggering Factors
Authors: Tinggie Tinialishel Laie Gostine , Tan Kim Hua , Muslim Nazri , Keng Lim Kar
Published: March 2023

Human interaction and support are key to students’ learning. In English as a second language (ESL) settings, peer scaffolding reinforces the traditional teacher–learner interaction. A lack of peer interaction among students, which is also a product of the COVID-19 pandemic, has resulted in young learners becoming overly reliant on teachers. This concern is a factor in hindering learners’ writing development. Inspired by the sociocultural perspective, this study employed a qualitative research design to explore the types of scaffolding behaviors among young learners. The analysis is based on the Taxonomy of Language Functions and what triggers these behaviors among primary ESL learners during classroom writing tasks. Data from 10 recordings of audiovisual materials and interviews were collected from 30 Year 6 primary school students and were analyzed using thematic analysis. The data analysis showed that scaffolding behaviors occurred continuously throughout each writing stage. The findings revealed that the preferred scaffolding behavior among learners was questioning. Eliciting questions was the most frequent type of inquiry that was applied during peer scaffolding. Results highlight the triggering factors that influenced scaffolding behaviors, which were learners’ level of competency, personalities, and accessibility to L1. This approach can be used as an alternate strategy for teaching writing because of its substantial impact on the writing ability of ESL students. The findings would provide a clear direction for ESL practitioners and learners to acknowledge the significance of learners’ behaviors and factors during peer scaffolding in assisting their development in writing attainment.