bluuebunny/crossref_metadata_2025 huggingface dataset:
Mathematical Model of Phytoplankton Interspecific Competition for Food Resource
Authors: Abakumov A.I. , Kozitskaya I.S.
Published: December 2023

The phytoplankton in an aquatic ecosystem is the basis of its life activity and the main producing link. The functioning of phytoplankton in same time depends on environmental factors: mineral nutrition, photosynthetically active solar radiation, water temperature and other less significant ones. Sunlight is a stable factor, varying predictably over time and space. The water temperature is the small regulatory factor. Concentrations of mineral substances can change quite quickly and significantly, this much influences on plant organisms. Thus, mineral nutrition is a basic environmental factor of influence to phytoplankton. On the other hand, in large aquatic basin such as seas and oceanic areas the distribution of living organisms is very heterogeneous in space. These two aspects – nutrient and spatial heterogeneity – are the focus of this article. A model of competitive interaction is considered using the example of two species of phytoplankton. The phytoplankton move passively in water what is simulated by the diffusion process. The model contains one non-trivial stationary and spatially homogeneous equilibrium and two trivial ones, i.e. degenerate in at least one species of phytoplankton. Trivial equilibria are stable only in some “degenerate” situations. The non-trivial equilibrium in “normal” conditions is stable to temporal and spatial disturbances. The behavior of solutions near a nontrivial equilibrium for a stationary living environment and in cases of its nonstationary is studied. Perturbation of a nontrivial equilibrium in a stationary environment leads to relatively long-term deviations from equilibrium and a slow return to it. The instability of trivial equilibria increases the spatial heterogeneity of solutions. At the same time, the nontrivial equilibrium computationally demonstrates weak properties of global stability in time. The unsteadiness of the environment is simulated by the unsteadiness of the influx of nutrients. It has been shown that the distribution of nutrients can lead to significant heterogeneity in the distribution of individuals across the spatial habitat.
The effect of DNA methyltransferase 3A suppression in progression of the resistance phenotype in breast cancer cells
Authors: Andreeva O. E. , Sorokin D. V. , Vinokurova S. V. , Shchegolev Yu. Yu. , Elkina N. V. , Katargin A. N. , Faskhutdinov R. S. , Salnikova D. I. , Scherbakov A. M. , Krasil’nikov M. A.
Published: December 2023

Introduction. Rearrangement of molecular pathways and activation of bypass signaling determine the progression of tumor cell resistance to various drugs. Study of the common features of resistant formation mechanisms is essential for breast and other cancer beneficial treatments.

Materials and methods. The present work was performed on estrogen receptor α ERα-positive (ERα – estrogen receptor α) McF-7 breast cancer cells, established sublines resistant to the mTOR inhibitor rapamycin or antiestrogen tamoxifen, and ERα-negative MDA-MB-231 breast cancer cells. Methods used include MTT test, transient transfection, immunoblotting, real-time polymerase chain reaction and methylation analysis by bisulfite pyrosequencing.

Results. We have shown that the resistance of breast cancer cells to targeted and hormonal drugs is associated with the suppression of DNA methyltransferase 3A (DNMT3A) and respective changes in DNA methylation; DNMT3A knockdown results in the partial resistance to both drugs demonstrating the pivotal role of DNMT3A suppression in the progression of cell resistance.

Conclusion. Totally, the results obtained highlight the possible mechanism of tumor cell resistance to targeting/hormonal drugs based on the deregulation of DNMTs expression and demonstrate  direct connection between DNMT3A suppression and resistance progression.
Relationship of transposable elements with long non-coding RNAs and peptides in carcinogenesis
Authors: Mustafin R. N.
Published: December 2023

It has been proven that 98 % of the human genome is transcribed. The main part of resulting molecules after their processing function as various RNA molecules, among which the best known are long noncoding RNA (lncRNA)  and microRNA. There are 126,000 lncRNA genes in humans that regulate transcription, translation, histone modifications, heterochromatin formation, splicing, microRNA expression and formation, and matrix RNA (mRNA)  post-transcriptional modifications. An important property of lncRNAs is their mutual and self-regulation by peptides formed during their translation, which also affect the expression of protein-coding genes. This property may be due to origin of lncRNAs from transposable elements and is a conservative evolutionary characteristic of lncRNA, as one of properties in formation of new genes for variability and adaptation.  The role of lncRNAs originating from retroelements and microRNAs formed during their processing in the specific regulation of genes involved in carcinogenesis has been proven. The peptides formed during lncRNA translation can be used as universal tools for targeted therapy of malignant neoplasms. Analysis of the scientific literature  made it possible to describe 21 lncRNAs that  are translated  to form peptides involved in specific tumors pathogenesis. Since the ability of lncRNA to self-regulate by products of its own translation, which is characteristic of all lncRNAs, is also a property of transposable elements, it is promising to study transposons and their relationship with lncRNAs for designing new therapeutic models.
Integration of phosphoinositide 3-kinase (PI3K) and transforming growth factor β1 (TGF-β1) signaling cascades: role in the therapeutic inefficiency of tamoxifen
Authors: Babyshkina N. N. , Uzyanbaev I.  A. , Dronova T.  A. , Cherdyntseva N. V.
Published: December 2023

Growth factors signaling cascades and their interaction with the central regulatory targets of tumor cells and estrogens are considered as the main mechanisms of hormonal resistance in breast cancer. The integration  of the transforming growth factor β1 (TGF-β1) and PI3K (phosphoinositide 3-kinase)/Akt (protein kinase B)/mTOR (mammalian target of rapamycin) signaling pathway may result in the activation of proliferation and, as a result, the development of an in-effective response to therapy and disease progression. The review summarizes a systematic analysis of the literature data on the role of TGF-β1 signaling in the mechanisms of tamoxifen resistance to in the aspect of interaction  with the PI3K/Akt/mTOR. The interaction between the estrogen receptors α signaling and tamoxifen, the mechanisms of regulatory activation of TGF-β1 and PI3K/Akt/mTOR, as well as their contribution to the tamoxifen response are considered. The direct involvement of TGF-β1/PI3K in the mechanisms of tamoxifen resistance to determines the prospects for studying the effector of these cascades as molecular targets. The knowledge accumulated to date allows considering the TGF-β1/PI3K signaling pathway as a potential molecular tool for the search for effective strategies for blocking the resistance of tumor cells to tamoxifen.
Molecular genetic markers of chemotherapy-induced cardiotoxicity in patients with oncohematological diseases (review)
Authors: Milyutkina Yu. S. , Sustretov A. S. , Limareva L.  V.
Published: December 2023

Cardiotoxicity of anticancer therapy is a severe adverse cardiovascular event affecting the survival of cancer patients. Modern methods for diagnosing cardiotoxicity allow to identify already occurred myocardial transformations, accompanied by symptoms of heart failure and are not predict and detect early changes in the heart tissue during treatment. Recently, increasing attention is paid to the search for molecular genetic markers, a single identification of which before starting treatment will make possible to determining the risks of cardiotoxicity and change treatment taking into account individual genetic characteristics. At the same time, most research on the effect of allelic variants of genes on cardio-vascular complications relate to chemotherapy of solid tumors. The review considered possible prognostic genetic variants of cardiotoxicity induced by chemotherapy in patients with the hematopoietic and lymphatic malignancies.
TALENT MANAGEMENT IN THE CIVIL SERVICE: THEORETICAL ASPECTS AND INNOVATIVE PRACTICES
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, OBUSHNA Nataliіa , VASYLEVSKA Tetiana ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Published: December 2023

The article substantiates the theoretical and applied aspects of talent management in the public service in conditions of uncertainty, taking into account innovative global HR practices in this area. The expediency of forming a talent management system as a leading modern trend in the field of human resources management in the public service has been proven. Arguments in favor of the introduction of knowledge management tools as a component of the talent management system in state authorities are outlined. An analysis of the main trends in changing approaches to personnel management during the period of change was carried out. Taking into account the principles of the Lifelong Learning concept, the issue of the formation and development of the talent management system in the civil service under martial law using such an innovative tool as distance learning (e-learning) is updated. The positive practice of using remote training of personnel in the State Migration Service of Ukraine (SMS) was considered, using the example of the implementation of special software of the Unified Information and Analytical System of Management of Migration Processes "Training of SMS employees". It was concluded that in order to ensure the successful development of the talent management system in the civil service in Ukraine in conditions of uncertainty, it is expedient to: ensure the transformation of personnel work units in state bodies into HR services; to develop tools for assessing the attractiveness of public service for potentially talented employees; introduce a system of mentoring in state bodies and create an effective system of non-material motivation of mentors for performing the mentor's functions; to introduce a succession planning system for senior positions in the civil service by restoring and modernizing the personnel reserve; carry out a comprehensive rebranding of the civil service; actively implement various training formats using interactive methods (E-Learning); etc.
Case Method in Training Specialists of Guardianship and Guardianship Authorities and Specialists of the Office of the Ombudsman for Children
Authors: Omelchenko A.S. , Volchanskaya V.O. , Kolesnikova U.V.
Published: December 2023

The article describes the experience of using the case method in training specialists from guardianship and guardianship authorities and specialists from the Office of the Commissioner for Children's Rights in the Russian Federation as part of the implementation of the supervision webinar cycle. Supervisory support of specialists in the field is organized in the format of online meetings, during which case studies from the practice of students were analyzed. The article offers an overview of the topics highlighted in the analysis of cases received from students, describes the key points in the discussion of the proposed cases from the standpoint of competence-based and practice-oriented approaches to adult learning. Supervision, built on the basis of real cases, contributed to the improvement and acquisition of new professional competencies within the framework of the qualifications of specialists in the field of child protection. The analysis of the received cases made it possible to identify the main deficits and educational needs of specialists, which can be used in further training of specialists.
Effect of the duration of temporary disability in dental diseases on the economically active population of the region: On the example of the Republic of Tatarstan
Authors: Saleev Rinat A. , Abdrashitova Alena B. , Safina Roza M.
Published: December 2023

BACKGROUND: Morbidity with a temporary disability is an informative objective criterion for assessing the health status of the working population. The special literature describes data on research activities of temporary disability examination services; however, the issues of clinical and statistical analyses of the duration of temporary disability in dental diseases and factors affecting it at the regional level have not been sufficiently investigated.
AIM: To determine the average duration of temporary disability for each class of dental morbidity at the regional level through clinical and statistical analyses.
MATERIALS AND METHODS: Cases of temporary disability established by dental medical organizations of the Republic of Tatarstan for 11 years were analyzed retrospectively. To calculate the intensive indicators, data of working patients who received dental treatment during the study period were assessed. Statistical analysis was performed using IBM SPSS Statistics version 23.
RESULTS: The average duration of temporary disability for each class of dental morbidity in the Republic of Tatarstan was 7.02±0.09 days. In addition, the duration of temporary disability in each group of dental diseases was influenced by the following factors: type of nosology, sex and age of the patient, and doctor’s experience. The duration was statistically significantly different depending on the nosological group of dental diseases (p 0.001). The average duration of cases was the greatest in patients with developmental abnormalities and injuries of the maxillofacial region, in whom surgical treatment and follow-up were performed on an outpatient basis (12.18±1.26 and 12.16±0.36 days, respectively).
CONCLUSION: This clinical and statistical study allows us to obtain reliable information about the state of dental morbidity in the economically active population of the Republic of Tatarstan, which is the basis for planning preventive measures, appropriate comprehensive treatment, and rehabilitation of patients.
Profilometric analysis of cross-linked collagen matrix for soft tissue thickness augmentation in dental implants: A randomized controlled clinical trial
Authors: Ashurko Igor P. , Galyas Anna I. , Magdalyanova Mary L. , Balyasin Maxim V. , Rasamatov Bekhruz B. , Kazumyan Sabina V. , Tarasenko Svetlana V.
Published: December 2023

BACKGROUND: Dental implantation is an effective method for rehabilitating patients without teeth. The long-term survival of implants is influenced by various factors, one of which is the condition of the soft tissue surrounding the implant.
AIM: To evaluate the effectiveness of cross-linked collagen matrix for soft tissue augmentation in the implant area.
MATERIALS AND METHODS: Thirty-two patients with soft tissue thickness deficiency were examined. The patients were divided into two groups depending on the method of surgery. Group 1 received a cross-linked collagen matrix, whereas group 2 underwent the transplantation of a free connective tissue graft. The increase in soft tissue thickness was assessed 3 and 6 months after surgery.
RESULTS: Soft tissue thickness 3 months after surgery increased by 1.77±0.61 and 1.26±0.41 mm in groups 1 and 2, respectively (p 0.001). Moreover, 6 months after surgery, soft tissue thickness increased by 1.11±0.44 and 1.43±0.81 mm compared with the initial value (p=0.012).
CONCLUSION: The use of the collagen matrix increases the soft tissue thickness in the implant area; however, the effect size is lower than that obtained by autograft transplantation.
La codocencia para la formación docente en educación integrada: una experiencia con STEAM y AICLE
Authors: Greca Ileana M. , Ortiz Revilla Jairo , Alonso-Centeno Almudena , Sanz de la Cal Esther
Published: December 2023

La realidad en la que vivimos y los problemas que actualmente se nos presentan requieren de una visión educativa competencial holística y no compartimentada. La implementación efectiva de enfoques educativos integrados pasa obligatoriamente por su comprensión por los docentes. El objetivo de este estudio es conocer si es viable mejorar la conceptualización de la integración disciplinar de estudiantes del Grado en Maestro de Educación Primaria con la implementación de una propuesta de codocencia entre dos disciplinas y tres áreas (Didáctica de las Ciencias Experimentales, de las Ciencias Sociales y de la Lengua y Literatura) donde se solicita al alumnado el diseño de un proyecto con enfoque STEAM y AICLE. Para ello, realizamos un estudio de métodos mixtos en los últimos dos cursos académicos en los que el alumnado desarrolló proyectos con enfoque STEAM y AICLE. En este artículo presentamos lo correspondiente a la parte cualitativa del último curso. Los resultados muestran una notable mejoría en esta comprensión después del desarrollo de la acción corta de codocencia. Este trabajo demuestra la superación de los argumentos sobre la supuesta incapacidad de los futuros maestros para formarse en enfoques integrados y abre una línea de investigación promisoria para el avance de la educación integrada.
Visual Effects in Movies: Bridging the Imagination-Reality Divide
Authors: Mandapuram Mounika
Published: December 2023

Visual effects, or VFX, have become essential to contemporary filmmaking. With the use of VFX, directors can take viewers to magical realms, recreate historical epochs, and give life to the wildest of their audiences' imaginations. VFX has revolutionized filmmaking, enabling directors to push the boundaries of storytelling. From otherworldly creatures to breathtaking landscapes, VFX artists bridge the gap between what the mind conceives and what the camera captures. This bridge connects the limitless realm of human imagination with the physical reality of cinematic storytelling. In this article, we highlight the significance of visual effects in modern filmmaking and underline their potential to blur the line between the fantastical and the virtual worlds they portray. In addition, the study digs into the seamless integration of visual effects into live-action sequences, which serves as an example of the artistry required to produce plausible illusions.
Coleção Gênesis: ciência e tecnologia
Authors:   Pontifícia Universidade Católica de Goiás, Eugênio Guimarães Nalini Lauro
Published: December 2023

O objetivo da Coleção Gênesis: ciência e tecnologia, é criar uma oportunidade para dar visibilidade ao trabalho de pesquisa dos nossos estudantes, com o registro da interação entre discentes e docentes orientadores, ao longo da condução da pesquisa. Para além disto, “publicar na Gênesis” poderá induzir mais dedicação ao processo formativo e, assim, o impulsionamento de ações voltadas a maior qualificação do processo de iniciação à pesquisa científica e tecnológica na PUC Goiás.
CASAIS HOMOAFETIVOS E A REPRODUÇÃO ASSISTIDA: UMA REVISÃO DOS AVANÇOS E DESAFIOS
Authors:   Pontifícia Universidade Católica de Goiás, Subtil Alves Lanna , Santos de Souza Hannum Juliana
Published: December 2023

A concepção de família sofreu alterações com o transcorrer do tempo, influenciada por questões sociais, econômicas e científicas. Com o advento da reprodução humana assistida, houve uma dissociação entre o sexo e a procriação, tornando assim o sonho da parentalidade acessível independentemente da capacidade reprodutiva. Porém, com essa possibilidade surgiram também questionamentos quanto as consequências legais, médicas e sociais do uso dessas técnicas por casais compostos por indivíduos do mesmo sexo. Objetivo(s): Este artigo tem como objetivo identificar, por meio de uma revisão da bibliografia, como evoluíram as questões legais, médicas e sociais do uso de técnicas de reprodução assistida por casais homoafetivos. Método: Foi realizada uma busca eletrônica de artigos indexados nas bases de dados Scielo, LILACS, Periódicos CAPES e Pubmed, no período de 2010 a 2020, sobre a temática. Resultado(s): Os achados da pesquisa foram classificados de acordo com o tema investigado nos seguintes eixos temáticos: mudanças na legislação; mudanças nas resoluções do CFM; mudanças na concepção de família e recepção pela sociedade. Conclusão: Pode- se concluir que houve avanço, especialmente em termos de reestruturação na noção de famílias, contudo ainda há desafios a serem superados, como a criação de legislação específica.
REPERTÓRIOS SOBRE MASCULINIDADES NEGRAS GAYS: UMA ANÁLISE DO FILME “MOONLIGHT – SOB A LUZ DO LUAR”
Authors:   Pontifícia Universidade Católica de Goiás, Matheus Oliveira Carvalho Breno , Santana Borges Lenise
Published: December 2023

a proposta deste trabalho é identificar e analisar os repertórios discursivos sobre masculinidades negras gays e seus efeitos na mídia fílmica, mais especificamente no filme Moonlight – sob a luz do luar. Investigar sobre masculinidades no contexto da negritude e da homossexualidade significa discutir preconceitos e estereótipos e repensar a possibilidade de construir outras versões e sentidos para esses sujeitos. Trata-se de uma pesquisa qualitativa exploratória, ancorada na vertente teórica do construcionismo social e na metodologia das práticas discursivas. Foi realizado um levantamento nas plataformas SciELO, BVS-PSI e na revista Periódicus, dessa busca obteve-se dez artigos que versam sobre masculinidades negras e gays. Observou-se que o tema das masculinidades está em foco atualmente, sendo considerado uma questão em ascensão. Sendo assim, espera-se, com esta pesquisa, contribuir com a literatura do tema na psicologia social e outros campos do saber.
Stress and its Effects on Medical Students in Early Years
Authors: Alharbi Renad , Alamri Danah , Ismail Amira
Published: December 2023

Introduction: Stress can have a variety of effects on a medical student’s performance. It can cause decreased concentration and memory retention, making it difficult to remember information. Furthermore, stress can cause anxiety, which can result in poor decision-making and mistakes in patient care. This study aims to assess the stress level among medical students during their early year of study. Methods and Instruments: A descriptive quantitative cross-sectional study was utilized on medical students in first, second and third years of their study in Fakeeh College for Medical Sciences, Jeddah, KSA; data collection was carried out to assess the medical students stress level. The levels of stress were assessed among these students using the Perceived Stress Scale- 10 item version (PSS-10), self-report scale measures the degree to which one feels overwhelmed and unable to predict the future. Results: A descriptive statistic of the ten items of the PSS questionnaire reveals that the high percent of students perceive two items (one and three) very often. The majority of respondents reported moderate level of stress level. However, The Pearson’s correlations between GPA and the average score of PSS was not statistically significant. Conclusion: There is a high percentage of moderate stress among medical students at Fakeeh College for Medical Sciences especially first year medical students; this requires special orientation program to improve students time management and study skills sessions. Further research is needed to explore the predisposing factors for this stress.
Fenpropathrin Induces Oxidative Stress, Inhibits Cholinesterase, and Causes Genotoxicity in Pethia conchonius (Hamilton, 1822)
Authors: Deshpande Akshay V. , Kadadevaru Girish G.
Published: December 2023

Pesticide contamination in water bodies is a serious threat to aquatic organisms. Among the new generation pesticides, synthetic pyrethroids enter the aquatic environment from agricultural runoff and are more persistent in aquatic environment. In this study, we investigated the effect of fenpropathrin, a type II pyrethroid, on Pethia conchonius. The median lethal concentration for commercial formulation of fenpropathrin (Danitol®) was determined to be 2.43 μg/L. Based on the median lethal concentration, the fish were exposed to 1/5th (0.486 μg/L) and 1/10th (0.243 μg/L) of median lethal concentrations for 30 days. After the exposure period, antioxidant enzymes status (superoxide dismutase and catalase), oxidative stress parameters (lipid peroxidation and reduced glutathione) in brain, liver, and kidney, cholinesterase enzyme activity in brain and muscles, and incidences of micronucleus were evaluated. In the treatment groups, alteration in antioxidant enzyme levels were observed in brain, liver, and kidney. Lipid peroxidation, which is indicative of oxidative stress, was observed but did not show much variation. Reduced glutathione was also altered. Cholinesterase activity was significantly different in the brain tissues between control and treatment groups; however, no significant difference was observed between the cholinesterase activities of muscles in control and treatment groups. Micronucleus incidence in treatment groups was higher than that in the control. Our study indicates that fenpropathrin altered the antioxidative enzyme status, inhibited cholinesterase activity in brain, and exhibited potential genotoxic effects in the fish Pethia conchonius.
Phytochemical Studies, Anti-Oxidant and Anti- Inflammatory Properties of Four Medicinal Plants
Authors: Sharma Ayushi , Goel Anjana
Published: December 2023

Rheumatoid arthritis, a chronic autoimmune disorder, is characterized by polyarthralgia and joint dysfunction resulting from autoimmune responses that target self-neoepitopes. These attacks lead to the activation of macrophages and other defense cells. By identifying these self-epitopes as biomarkers in RA, researchers have gained valuable insights into the disease’s pathogenesis. Over the years, research has focused on investigating the potential of medicinal plants as antiinflammatory agents. In this study, a hydroethanolic extract of Saraca asoca, Ficus benghalensis, Chenopodium album, and Nyctanthes arbor-tristis leaves was prepared by Soxhlet apparatus. Various concentrations of extracts were utilized to assess phytochemical analysis, GC-MS, in-vitro anti-oxidant, and anti-inflammatory activities. The highest scavenging potential was exhibited by Chenopodium album, as assessed by the DPPH assay (90.32 ± 3.2 %) and H2O2 (86.00 ± 1.94 %). Similarly, the Nyctanthes arbor-tristis showed (92.23 ± 0.83 %) inhibition in membrane stabilization assay, and (91.49 ± 1.03 %) in protein denaturation inhibition capacity. GCMS analysis showed various phytoconstituents in extracts. In order to confirm its therapeutic potential for treating RA, Nyctanthes arbor-tristis may be a better drug candidate that needs to be further researched for mechanistic studies.
Enhancing Agricultural Sustainability through Microbial-Mediated Abiotic Stress Tolerance
Authors: Singh Pankaj , Rayeen Fareha , Singh Ranjan , Pathak Neelam , Singh Rudra Pratap , Tiwari Vidyanand , Tripathi Manikant , Singh Pradeep Kumar
Published: December 2023

Global environmental problems lead to plants life extremely stressful. Plants are exposed to more prevalent incidences of abiotic stresses like salinity, drought, high temperature, etc. The most significant factors that reduce agricultural productivity are abiotic stresses. Plants are part of ecosystem entities, and the future of sustainable agriculture will be based on the exploitation of the potential of plant-associated microbial communities. Microorganisms produce significant amounts of metabolites that help plants to cope with these stresses. Plants interactions with microorganisms create a diverse ecosystem in which both partners occasionally share a cooperative relationship. This review emphasizes the plant-microbe interactions and provides a roadmap that how microorganisms such as Arbuscular Mycorrhizal Fungi, Plant Growth Promoting Rhizobacteria and endophytes are used to mitigate the negative effects of various stresses to improve crop productivity. This review also elaborates molecular and biochemical mechanisms in plants and microbes to tolerate abiotic stress. Furthermore, the most recent developments in the study of plant-microbe intermodulation with a novel approach will allow us to use a multifaceted tool “biostimulants” against abiotic stress. The important challenges of commercializing biostimulants for improving crop yield under several plant growth environmental constraints are also included in this review. As a result, the purpose of this review is to illustrate the effects of different abiotic stressors on plants, as well as the role of beneficial plant microbes in helping to overcome the negative impact of abiotic stresses.
A Systematic Review on Musculoskeletal Disorders among Workers in Unorganized Sector
Authors: Mishra Savita , Kiran U. V.
Published: December 2023

Musculoskeletal Disorders (MSDs) are a group of medical conditions that affect the musculoskeletal systems, which include muscles, tendons, ligaments, and nerves, that support the body and allow movement. In the context of workers in the unorganized sector, due to the nature of their profession, MSDs are expected, which often involve repetitive motions, heavy lifting, awkward postures, and other physical demands. Loss of money, decreased productivity, and a decline in quality of life are all possible consequences for the workers. Therefore, it is crucial to prevent and manage MSD among workers in the unorganized sector such as improving working conditions, providing training on safe work practices, and promoting early detection and treatment of MSD. The study aims to identify the variables that affect informal worker’s quality of life. The researcher gathered the available data and suggested a few guidelines. The condition of employees may be improved with certain adjustments to the workplace, work tools, worker health, work duties, and work management.
Optimal timing of satellite data acquisition for estimating and modeling soil salinity in cotton fields of the Mingbulak District, Uzbekistan
Authors: KHOLDOROV Shovkat , JABBAROV Zafarjon , YAMAGUCHİ Tomoaki , YAMASHİTA Megumi , SHAMSİDDİNOV Tulkin , KATSURA Keisuke
Published: December 2023

Agriculture is frequently hampered by soil salinity, which has a negative impact on crop growth and yield. This study aims to identify the optimal timing of satellite data acquisition to predict soil salinity levels indirectly using satellite images in cotton growth fields as a basis. Data was collected in the Mingbulak district of Uzbekistan, where soil electrical conductivity (EC) was measured in a laboratory using soil samples collected from various fields with similar management practices. In this research, we present a linear regression model that uses satellite data and the Normalized Difference Salinity Index (NDSI) to forecast soil salinity levels indirectly. The results of the linear regression analysis showed a positive correlation between the soil electrical conductivity values and the NDSI values for each month, with August having the highest correlation (R2 = 0.70). The study found that the cotton growth stages and the process of soil salinity formation in the study area were the main factors affecting the correlation between electrical conductivity and NDSI. The model developed in this study has R2 value of 0.70. This suggests a moderate to strong relationship between the two variables, which is promising for the indirect assessment of soil salinity using the NDSI index. The study discovered a positive relationship between soil electrical conductivity and NDSI values, which were highest in pre-flowering and flowering stages of cotton. Our findings show that satellite-based estimation and modeling with NDSI can be used to indirectly assess cotton field soil salinity, especially during the pre-flowering and flowering stages. This study contributes to the development of optimal satellite data acquisition timing, which can improve soil salinity predictions and agricultural productivity.
Soil fertility status, productivity challenges, and solutions in rice farming landscapes of Azerbaijan
Authors: İSLAMZADE Tariverdi , BAXİSHOV Deyanet , GULİYEV Alovsat , KIZILKAYA Rıdvan , İSLAMZADE Rahila , AY Abdurrahman , HUSEYNOVA Sultan , MAMMADOVA Mirvari
Published: December 2023

Rice, a fundamental staple globally, plays a pivotal role in addressing food security and nutrition. This study explores the intricate interplay between soil characteristics, productivity challenges, and solutions in Azerbaijan's rice farming landscapes, acknowledging the agricultural importance of rice and its contribution to human nutrition. This study aims to assess the physical and chemical properties of soil samples from Azerbaijan's rice cultivation areas, with a focus on nutrient content and the identification of elements limiting productivity and plant nutrition. By synthesizing these perspectives, the study enriches the understanding of the complex relationship between soil fertility class and rice productivity, offering insights for sustainable rice farming. Soil samples were collected from representative rice fields across Azerbaijan and analyzed for various parameters, including soil texture, pH, electrical conductivity, organic matter, and nutrient content. The soil sampling and preparation process maintained the integrity of collected samples, providing a reliable basis for scientific analysis. The results reveal diverse soil properties, with clayey texture prevailing. Soil acidity, salinity, and nutrient deficiencies pose challenges, emphasizing the need for corrective measures. The majority of soils exhibit unsuitable pH levels and elevated sodium content, necessitating interventions such as soil acidification and sodicity remediation. Soil salinity issues highlight the importance of drainage and leaching practices. Low organic matter and nutrient deficiencies, particularly zinc and manganese, underscore the need for targeted interventions, including foliar applications. Overall, Azerbaijan's rice-cultivated areas face challenges related to soil fertility, salinity, and nutrient deficiencies, impacting productivity. Corrective measures, such as soil reclamation, proper fertilization, and foliar applications, are crucial for enhancing crop yields. The study contributes valuable insights for local practices and the broader global pursuit of sustainable rice farming, emphasizing the importance of tailored strategies in addressing specific regional challenges.
State regulation and deregulation: Law and economics in modern Russia
Authors:   Penza State University, Romanovskaya Olga V.
Published: December 2023

Introduction. The legal aspects of state regulation of economic relations are of high relevance for the Russian Federation due to the development of modern crisis situations. At present, it is necessary to study the general parameters of the interaction between law and economics, on the basis of which it is possible to develop specific recommendations for improving Russian legislation. Empirical analysis. The author presents general factors that have a serious (in the long term) impact on the Russian economy: gradual decarbonization; the emergence of the concept of sustainable development, establishing a link between GDP growth (gross domestic product) and concern for future generations; universal digitalization affecting all spheres of public life. Methods and concepts. The confrontation between the two global currents of libertarianism and Keynesianism has a serious impact on the limits of state intervention in economic relations. At the same time, the gradual convergence leads to the development of such concepts as the social market economy and libertarian paternalism, each of them involving a transition to indirect influence and taking into account social factors in creating a competitive environment. The absence of a direct consolidation of the foundations of the economic system in the Constitution of Russia implies the development of synthetic principles that need further constitutionalization. Theoretical analysis. In the Russian Federation, the further strengthening of the direct role of the state in the country’s economy has institutional grounds – a large bureaucratic apparatus and a significant public sector in the economic system. At the same time, legal support for various forms of deregulation (self-regulation, co-regulation, quasi-regulation, etc.) has been formed. The declared "regulatory guillotine", in isolation from the general directions of administrative reform, is unlikely to have a significant long-term effect. Results. The process of deconcentration of power (with deregulation being one of the aspects) in the Russian Federation cannot be considered complete. Deregulation is not the only form of deconcentration and reduction of the administrative burden on businesses.
Acceptance of Information and Communication Technology and Its Related Factors among Older Adults; a Cross-Sectional Study in Iran
Authors: Rezaeipandari Hassan , Dehghanbanadaki Elahe , Madadizadeh Farzan
Published: December 2023

Introduction: Given the increasing elderly population and the decreasing role of families in elderly care, the use of up-to-date technologies by older adults will become increasingly important in helping them live healthier and better lives. This study aimed to determine the acceptance of information and communication technology (ICT) by older adults and related factors in Yazd city, Iran.
 
Methods: This cross-sectional study was conducted in 2022 with the participation of 360 older adults aged over 60 years from comprehensive health care centers in Yazd city, Iran. Participants were selected using a multi-stage random sampling method. Data were collected using a demographic information questionnaire and an Information and Communication Technology Acceptance Questionnaire completed by interview. Data were analyzed using descriptive indices, independent two-sample t-tests, one-way analysis of variance, and regression by SPSS.
 
Results: The ICT acceptance rate among older adults was 22.5%. The highest mean score was related to the dimension of perceived usefulness (15.37). The most significant barriers to ICT acceptance were lack of interest (48.6%), lack of sufficient skills (46.4%), and lack of perceived need (45.3%). The regression results showed that age, level of education, smartphone use, and time spent on technology tools were predictors of ICT acceptance by older adults, accounting for 82% of the variance in ICT acceptance.
 
Conclusion: Given the low level of technology acceptance among older adults in Yazd city and the need to learn and use ICT to meet their individual, social, health, and medical needs, as well as to live a more independent life and save time and costs, providing older adults with the opportunity to become familiar with technology is essential.
Effectiveness of English Language Teaching on Aggression and Anxiety in the Elderly with Alzheimer’s Disease
Authors: Mehrara Maryam , Rad Neda Fatehi , Jalali Valeh
Published: December 2023

Introduction: When aging starts, the human being becomes prone and vulnerable to a variety of diseases and disorders, specifically Alzheimer’s disease (AD), which is the main reason for about 80% of the cases of dementia in older adults. AD is associated with a range of challenging disorders, such as aggression and anxiety, which make the lives of patients more difficult. This study aimed at investigating the impact of English language teaching on aggression and anxiety among older people with AD.
 
Methods: The design of this study was quasi-experimental pre-test post-test with the control group. The participants of the study included 40 Iranian (20 males and 20 females) older adults (≥ 65 years) who were suffering from AD in Kerman province, Iran, and also they were selected through convenience sampling. The exercise group participated in 20 sessions of English language teaching three times a week in 40 minutes. Then, the effect of English language teaching on both aggression and anxiety was analyzed. The required data were collected through the Persian version of the Bass-Perry Aggression Questionnaire and the Persian version of the Spielberger State‐Trait Anxiety Inventory. Data analysis was conducted by running descriptive statistics, Kolmogorov-Smirnov normality test, Leven test, and one-way Analysis of Covariance (ANCOVA).
 
Results: English language teaching significantly affected aggression among older people with AD (F= 9.112 p < 0.05, w2 = 0.178) similarly; it significantly affected anxiety (F = 9.147 p < 0.05, w2 = 0.130).
 
Conclusion: English language teaching significantly improves aggression and anxiety among older people with AD. The findings have implications for the elderly with AD and their families, psychiatrists, and English language teaching policymakers.
Effect of Polycyclic Aromatic Hydrocarbons Extracted from Indoor Air of Coffee Shops on Oral Squamous Carcinoma Cell (KB/C152): An in Vitro Approach
Authors: Sargazi Shahnaz , Ebrahimi Ali Asghar , Tabatabaei Seyed Mehdi , Ehrampoush Mohammad Hassan , Saravani Ramin , Sakhvidi Mohammad Javad Zare , Fallahzadeh Hossein , Shahraki Sheida
Published: December 2023

Introduction: The two main causes of indoor air pollution (IAP) are cooking and smoking. Toxic substances, including polycyclic aromatic hydrocarbons (PAHs), recognized as human carcinogens, are present in cooking and tobacco smoke. This study aims to determine the cytotoxicity and genotoxicity of PAHs collected from the indoor air of coffee shops on human cell line (KB/C152) in vitro approach.
Materials and methods: Sampling pumps at a 2 l/min flow rate for 5 hours were applied to collect indoor air samples. Next, KB cells in cell culture medium were exposed to different concentrations of extracted PAHs using Methyl Thiazolyl Tetrazolium (MTT) test. Finally, terminal dUTP nick-end labeling (TUNEL) test and cell cycle assessments were both examined using flow cytometry.
Results: The MTT test revealed a significant cytotoxic effect on KB cells depending on the PAHs concentrationas compared to the control cell line. The lethal concentration 50 (LC50) value against KB cells was 100 ± 3.09 µg/ml. Accordingly, exposure to extracted PAHs resulted in an arrest in the cell cycle at the sub-G1 checkpoint. The extracted PAHs suppressed the cell cycle in the sub-G1 phase, damaged DNA, and arrested KB cells from proliferating. Additionally, a statistically significant increase in DNA cleavage percentages (p ≤ 0.05) was seen in the TUNEL test, which also showed a dose-dependent increase in DNA damage.
Conclusion: Extracted PAHs caused DNA damage and arrested in the cell cycle in epidermoid carcinoma of the mouth cells (KB/C152) in vitro mechanisms. This evaluation highlights mechanisms of exposure to extracted PAHs and their detrimental health effects.
Peritonitis in patients on peritoneal dialysis: a 12-year experience from a large medical center in Bursa
Authors: GÜL Bülent
Published: December 2023

Objectives: Despite all technical advances, Peritonitis remains the most important peritoneal dialysis (PD) complication. Peritonitis causes complications such as additional hospitalization, technical failure, peritoneal membrane damage, consequent transition to hemodialysis, and death in this patient group. Early diagnosis, isolation of the causative pathogen with appropriate methods as soon as possible, and determination of antibiotic susceptibilities play a crucial role in solving the problem of treating peritonitis in PD. This study evaluated the frequency of peritonitis, culture positivity rate, and prognosis in peritoneal dialysis patients in our unit for 12 years.
Methods: A total of 171 patients (80 F, 91 M; mean age: 51.9±15.3 year; mean PD duration 36.5±36.4 months) who were followed up in our department between January 2009 and July 2021 were included in the study. Patient records were retrospectively analyzed.
Results: Peritonitis never occurred in 105 of the 171 patients included in the study. Of the remaining 66 patients, 43 had one peritonitis attack, and 23 had more than two. The mean peritonitis rate was 1.68±1.36. One hundred eleven episodes of peritonitis were detected in 66 of the patients. Bacterial growth was observed in 63.06% of the culture samples obtained from the 93 peritonitis episodes. The peritoneal catheter was withdrawn in 14 (21.21%) cases.
Conclusion: In our unit, the rate of culture positivity was 63.06%, and the peritonitis attack rate was 0.017 per patient-month and 0.211 per patient-year over a period of twelve years, with a mean of 57.1 patient months of peritonitis.
FKKT Navdih Znanosti – Študij na FKKT
Authors: Slemnik Mojca
Published: December 2023

Brošura predstavlja predstavitev študija na FKTT UM, predstavlja vizijo in poslanstvo fakultete, možnosti nadaljevanja študija in opravljanja poklica ter predstavitev predmetnikov na vseh stopnjah in smereh študija
Problematyczne zachowania uczniów szkoły podstawowej na zajęciach wychowania fizycznego
Authors: Ostrowska Małgorzata
Published: December 2023

Artykuł jest próbą rozpoznania i ustalenia związków i zależności pomiędzy kulturą organizacyjną szkoły podstawowej a postawami uczniów. Celem podjętego postępowania badawczego jest ukazanie problematycznych zachowań uczniów podczas zajęć wychowania fizycznego oraz analiza pedagogiczna niejednoznacznych sytuacji na tle braku racjonalnego podejścia do kwestii pożądanych modeli organizacyjnych procesu dydaktyczno-wychowawczego. Materiał empiryczny stanowiła grupa badawcza obejmująca 101 uczniów szkoły podstawowej tworzących cztery zespoły ćwiczebne. Autorka odnotowała wyniki otrzymane na podstawie retrospekcji pedagogicznej (metoda obserwacji bezpośredniej, metoda analizy dokumentów). Uwzględniono również refleksje (podejście jakościowe) zaangażowanych nauczycieli na temat problematycznych zachowań dzieci i młodzieży w zależności od warunków ćwiczebnych. Okres odnotowywania danych to wrzesień–listopad 2019 (łączone grupy z klas IV – 25 uczniów; łączone grupy z klas VI – 26 uczniów) oraz wrzesień – początek listopada 2022 (łączone grupy z klas IV – 24 uczniów, łączone grupy z klas VII – 26 uczniów). Przedsięwzięcie pedagogiczne służyło zebraniu informacji umożliwiających odpowiedź na postawione pytanie badawcze: Czy niewystarczające warunki przestrzenne sprzyjają problematycznym zachowaniom uczniów wybranej szkoły podstawowej? W odpowiedzi na sformułowane pytanie badawcze stwierdzono, że niewystarczające warunki przestrzenne sprzyjają problematycznym zachowaniom uczniów w różnej formie i o różnorodnym nasileniu.
Assessment of Some Physiological and Biochemical Traits for Selection of Tolerant Barley Genotypes (Hordeum vulgare L.) in Rainfall Conditions
Authors: Berkane I. , Bendada H. , Frih B. , Belagrouze A. , Louahdi N. , Mehanni O. , Selloum S. , Benniou R. , Guendouz A. , Laouisset M.B.
Published: December 2023

Background: in this study we aim to evaluate some physiological and biochemical important traits for the selection of tolerant Barley genotypes in the rainfall conditions. Methods: This experiment was conducted during the cropping season (2020-2021) at the experimental field of ITGC, Setif, Algeria. Ten genotypes of barley were used in this study to evaluate their performances with Chlorophyll contents, relative water contents, drought sensitivity index, proline content, total soluble sugar content, thousand kernels weight and grain yield. The seeds were sown using an experimental drill in 1.2 m x 5 m plots consisting of 6 rows with a 20 cm row space and the seeding rate is about 250 seeds per m2. Result: Analysis of variance showed that genotype effect was significatif to very high significatif with all studied parameters, the origin of the genotypes tested was only influenced the drought sensitivity index while the row type had a significatif effect on drought sensitivity index and proline contents grain yield was positively correlated with relative water contents however, thousand kernels weight was negatively correlated with relative water contents and Total soluble sugar content. Principal components analysis showed that PC1 was a physio-biochemical axis and the genotypes related to this axis had high values of these traits, while PC2 was a yield and drought tolerance axis and their related genotypes were the most yielding genotypes.