bluuebunny/crossref_metadata_2025 huggingface dataset:
Mechanical Characterisation and Shrinkage of Thermoactivated Recycled Cement Concrete
Authors: Real Sofia , Bogas José Alexandre , Carriço Ana , Hu Susana
Published: March 2021

This paper investigates the mechanical and shrinkage behaviour of concrete with recycled cement (RC) thermoactivated from waste cement paste and waste concrete. Overall, compared to ordinary Portland cement (OPC), for the same water/binder ratio, the mechanical strength and ultrasonic pulse velocity were not significantly influenced by the incorporation of RC. The elasticity modulus decreased with the addition of RC and the shrinkage tended to increase at high RC content. The incorporation of up to 15% RC allowed the production of workable concrete with identical shrinkage and similar to higher mechanical strength than concrete with only OPC. RC proved to be a very promising more eco-efficient supplementary cementitious material.
Efficient Adsorbent-Desiccant Based on Aluminium Oxide
Authors: Meshcheryakov Eugene P. , Reshetnikov Sergey I. , Sandu Mariya P. , Knyazev Alexey S. , Kurzina Irina A.
Published: March 2021

The review describes the main methods of obtaining hydroxides and aluminium oxides (AO) of various structures from gibbsite. The promising techniques of obtaining AO adsorbents are discussed, namely the technique of thermal activation in the mode of pneumatic transport with gibbsite by heated air (TCA Gb) and the technique of thermal activation of gibbsite in centrifugal flash reactors (CTA Gb). The main methods of improving the adsorbent properties of AO, such as the optimisation of texture characteristics and phase composition, as well as the influence of the modification of aluminium oxide adsorbents, obtained using CTA and TCA technologies with cations of alkaline metals, are considered. It is shown that the modification allows a controlled variation of the characteristics of donor and acceptor active sites on the surface of adsorbents and, thus, a substantial increase in their adsorption activity, in particular, with respect to water vapour.
Entomopathogenic Fungi Biomass Production and Extracellular Biosynthesis of Silver Nanoparticles for Bioinsecticide Action
Authors: Santos Tárcio S. , Passos Eliana M. dos , Seabra Matheus G. de Jesus , Souto Eliana B. , Severino Patrícia , Mendonça Marcelo da Costa
Published: March 2021

Entomopathogenic fungi are microbial agents of insect control in nature. They have been used as biologic strategies to manage insect invasion; however, the challenge is to maintain their shelf life and viability when exposed to high temperatures, ultraviolet radiation, and humidity. Synthesized silver nanoparticles (AgNPs) from fungal extracellular enzymes are an alternative using these microorganisms to obtain nanoparticles with insecticidal action. The present study evaluates the biomass production and the potential to synthesize silver nanoparticles using entomopathogenic fungi isolates. Sixteen isolates of entomopathogenic fungi were used in this study. The fungi pathogenicity and virulence were evaluated using the insect model Tenebrio molitor, at a concentration of 5 × 106 conidia/mL. The fungal biomass was produced in a liquid medium, dried, and weighed. The synthesis of silver nanoparticles was performed with aqueous extracts of the entomopathogenic fungi and silver nitrate solution (1 mM), following characterization by a UV/vis spectrophotometer, mean size, and polydispersity index. The results showed a significant variation in pathogenicity, virulence, and biomass production among the evaluated fungi isolates; however, only one of the isolates did not have the potential to synthesize silver nanoparticles. Pearson’s correlation showed significant correlation values only between virulence × biosynthesis potential and biomass production × biosynthesis potential, both with negative values, indicating an inverse correlation. Thus, AgNPs with entomopathogenic fungus extract can produce an innovative bioinsecticide product using a green production process.
Bayesian Model Infers Drug Repurposing Candidates for Treatment of COVID-19
Authors: Kiebish Michael A. , Shah Punit , Sarangarajan Rangaprasad , Vishnudas Vivek K. , Gesta Stephane , Tekumalla Poornima K. , Bountra Chas , Granger Elder , Schadt Eric , Rodrigues Leonardo O. , Narain Niven R.
Published: March 2021

The emergence of COVID-19 progressed into a global pandemic that has functionally put the world at a standstill and catapulted major healthcare systems into an overburdened state. The dire need for therapeutic strategies to mitigate and successfully treat COVID-19 is now a public health crisis with national security implications for many countries. The current study employed Bayesian networks to a longitudinal proteomic dataset generated from Caco-2 cells transfected with SARS-CoV-2 (isolated from patients returning from Wuhan to Frankfurt). Two different approaches were employed to assess the Bayesian models, a titer-center topology analysis and a drug signature enrichment analysis. Topology analysis identified a set of proteins directly linked to the SAR-CoV2 titer, including ACE2, a SARS-CoV-2 binding receptor, MAOB and CHECK1. Aligning with the topology analysis, MAOB and CHECK1 were also identified within the enriched drug-signatures. Taken together, the data output from this network has identified nodal host proteins that may be connected to 18 chemical compounds, some already marketed, which provides an immediate opportunity to rapidly triage these assets for safety and efficacy against COVID-19.
Seismic Resistance and Parametric Study of Building under Control of Impulsive Semi-Active Mass Damper
Authors: Shih Ming-Hsiang , Sung Wen-Pei
Published: March 2021

When high-rise buildings are shaken due to external forces, the facilities of the building can be damaged. A Tuned Mass Damper (TMD) can resolve this issue, but the seismic resistance of TMD is exhausted due to the detuning effect. The Impulsive Semi-Active Mass Damper (ISAMD) is proposed with fast coupling and decoupling at the active joint between the mass and structure to overcome the detuning effect. The seismic proof effects of a high-rise building with TMD and ISAMD were compared. The numerical analysis results indicate that: (1) the reduction ratio of the maximum roof displacement response and the mean square root of the displacement reduction ratio of the building with the ISAMD were higher than 30% and 60%, respectively; (2) the sensitivity of the efficiency index to the frequency ratio of the ISAMD was very low, and detuning did not occur in the building with the ISAMD; (3) to achieve stable seismic resistance of the ISAMD, its frequency ratio should be between 2 and 4; (4) the amount of displacement of the control mass block of the ISAMD can be reduced by enhancing the stiffness of the auxiliary spring of the ISAMD; and (5) the proposed ISAMD has a stable control effect, regardless of the earthquake distance.
A Novel Self-Forming Virtual Sub-Nets Based Cross-Layer MAC Protocol for Multihop Tactical Network
Authors: Rukaiya Rukaiya , Khan Shoab Ahmed , Farooq Muhammad Umar , Hussain Farhan
Published: March 2021

A tactical network mainly consists of software-defined radios (SDRs) integrated with programmable and reconfigurable features that provide the addition and customization of different waveforms for different scenarios, e.g., situational awareness, video, or voice transmission. The network, which is mission-critical, congested, and delay-sensitive, operates in infrastructure-less terrains with self-forming and self-healing capabilities. It demands reliability and the need to survive by seamlessly maintaining continuous network connectivity during mobility and link failures. SDR platforms transfer large amounts of data that must be processed with low latency transmissions. The state-of-the-art solutions lack the capability to provide high data throughput and incorporate overhead in route discovery and resource distribution that is not appropriate for resource-constrained mission-critical networks. A cross-layer design exploits existing resources to react to environment changes efficiently, enable reliability, and escalate network throughput. A solution that integrates SDR benefits and cross-layer optimization can perform all the mentioned operations efficiently. In tactical networks, SDR’s maximum usable bandwidth can be utilized by exploiting radios’ autonomous behavior. This paper presents a novel virtual sub-nets based cross-layer medium access control (VSCL-MAC) protocol for self-forming multihop tactical radio networks. It is a MAC-centric design with cross-layer optimization that enables dynamic routing and autonomous time-slot scheduling in a multichannel network environment among SDRs. The cross-layer coupling uses link-layer information from the hybrid of time division multiple access and frequency division multiple access (TDMA/FDMA) MAC to proactively enable distributed intelligent routing at the network layer. The virtual sub-nets based distributed algorithm exploits spectrum resources and provides call setup with persistently available k-hop route information and simultaneous collision-free transmission of voice and data. The experimental results over extensive simulations show significant performance improvements in terms of minimum control overhead, processing time in relay nodes, a substantial increase in network throughput, and lower data latency (up to 76.98%) compared to conventional time-slotted MAC protocols. The design is useful for mission-critical, time-sensitive networks and exploits multihop simultaneous communication in a distributed manner.
Interictal Photophobia and Phonophobia Are Related to the Presence of Aura and High Frequency of Attacks in Patients with Migraine
Authors: Pinheiro Carina F. , Moreira Jessica R. , Carvalho Gabriela F. , Zorzin Leticia , Dach Fabiola , Bevilaqua-Grossi Debora
Published: March 2021

Background: Despite that photophobia and phonophobia are well-known symptoms related to migraine, it is unclear whether they affect daily life activities during the headache-free period. Objective: To evaluate the interictal photophobia/phonophobia intensity during daily activities in migraineurs and non-headache individuals. Methods: Women with migraine without aura (MoA, n = 30), migraine with aura (MA, n = 30), chronic migraine (CM, n = 30) and without headache (CG, n = 30) reported the photophobia and phonophobia intensity during daily activities using a Likert scale ranging from 0 (no discomfort) to 10 (maximum discomfort). Results: The migraine groups reported higher intensity of interictal photophobia and phonophobia than CG during “driving” and “social situations”, respectively (p < 0.05). MA and CM groups presented higher intensity of phonophobia than CG, hearing sounds in everyday situations and listening to conversations in noisy places (p < 0.05). Also, the MA group presented higher interictal phonophobia than the CG to keep concentration in noisy places (p < 0.05). Weak positive correlations were observed between the intensity of both photophobia and phonophobia with migraine intensity, frequency of migraine and frequency of aura (p < 0.05). Conclusion: Interictally, the intensity of photophobia and phonophobia reported during daily activities is higher in patients with migraine, especially those with aura and chronic migraine, than in non-headache subjects.
A Speech Command Control-Based Recognition System for Dysarthric Patients Based on Deep Learning Technology
Authors: Lin Yu-Yi , Zheng Wei-Zhong , Chu Wei Chung , Han Ji-Yan , Hung Ying-Hsiu , Ho Guan-Min , Chang Chia-Yuan , Lai Ying-Hui
Published: March 2021

Voice control is an important way of controlling mobile devices; however, using it remains a challenge for dysarthric patients. Currently, there are many approaches, such as automatic speech recognition (ASR) systems, being used to help dysarthric patients control mobile devices. However, the large computation power requirement for the ASR system increases implementation costs. To alleviate this problem, this study proposed a convolution neural network (CNN) with a phonetic posteriorgram (PPG) speech feature system to recognize speech commands, called CNN–PPG; meanwhile, the CNN model with Mel-frequency cepstral coefficient (CNN–MFCC model) and ASR-based systems were used for comparison. The experiment results show that the CNN–PPG system provided 93.49% accuracy, better than the CNN–MFCC (65.67%) and ASR-based systems (89.59%). Additionally, the CNN–PPG used a smaller model size comprising only 54% parameter numbers compared with the ASR-based system; hence, the proposed system could reduce implementation costs for users. These findings suggest that the CNN–PPG system could augment a communication device to help dysarthric patients control the mobile device via speech commands in the future.
Impact Fracture and Fragmentation of Glass via the 3D Combined Finite-Discrete Element Method
Authors: Lei Zhou , Rougier Esteban , Knight Earl E. , Zang Mengyan , Munjiza Antonio
Published: March 2021

A driving technical concern for the automobile industry is their assurance that developed windshield products meet Federal safety standards. Besides conducting innumerable glass breakage experiments, product developers also have the option of utilizing numerical approaches that can provide further insight into glass impact breakage, fracture, and fragmentation. The combined finite-discrete element method (FDEM) is one such tool and was used in this study to investigate 3D impact glass fracture processes. To enable this analysis, a generalized traction-separation model, which defines the constitutive relationship between the traction and separation in FDEM cohesive zone models, was introduced. The mechanical responses of a laminated glass and a glass plate under impact were then analyzed. For laminated glass, an impact fracture process was investigated and results were compared against corresponding experiments. Correspondingly, two glass plate impact fracture patterns, i.e., concentric fractures and radial fractures, were simulated. The results show that for both cases, FDEM simulated fracture processes and fracture patterns are in good agreement with the experimental observations. The work demonstrates that FDEM is an effective tool for modeling of fracture and fragmentation in glass.
Health Status of Adults with Hearing Loss in the United States
Authors: Glassman Jennifer , Jordan Timothy , Sheu Jiunn-Jye , Pakulski Lori , Thompson Amy
Published: March 2021

Purpose: The purpose of this study was to identify the current health status of adults in the United States with self-reported hearing loss and compare it with US adults with a self-reported excellent or good hearing in three areas: (1) chronic disease states and general health status, (2) medical screening behaviors, and (3) lifestyle behaviors. Methods: A secondary data analysis was conducted using the 2014 data set from the National Health Interview Survey (NHIS), specifically the Sample Adult Public Use File (samadult). For this questionnaire set, one adult per family was randomly selected. This individual self-reported their response to the questionnaire items. Binary regressions were used to analyze the odds ratio to find differences for selected disease states, screenings, and lifestyle behaviors. Respondents were grouped into one of four categories: excellent/good hearing, a little trouble hearing, moderate/a lot of trouble hearing, and deaf. Results: The excellent/good hearing group was used as the comparison group for the other three levels of hearing. There are many differences in likelihood to self-report disease states; the greatest increased likelihoods include tinnitus and heart disease, with tinnitus being 8.6 times more likely for those who identified as having moderate/a lot of hearing loss. Those with any level of hearing loss were 3 to 5 times more likely to self-report heart disease. Regarding lifestyle factors, individuals with any level of hearing loss were less likely to consume alcohol and 2.5 to 9 times more likely to be unable to engage in moderate or vigorous activity on a weekly basis, respectively. Conclusions: There is a difference in the health status of individuals with hearing loss across all three areas examined (chronic disease states and general health status, medical screening behaviors, and lifestyle behaviors), and those differences vary based on level of hearing loss, the most notable being the self-reported inability to engage in moderate and vigorous physical activity. Disproportionate rates of tinnitus and heart disease were evident in all levels of hearing loss but most notable in those identifying as having moderate/a lot of trouble hearing. Further interdisciplinary research is necessary to improve the health of individuals with all levels of hearing loss, increase awareness of the hearing/health connection, and decrease hearing loss in general.
Determination of the Concentration of IgG against the Spike Receptor-Binding Domain That Predicts the Viral Neutralizing Activity of Convalescent Plasma and Serum against SARS-CoV-2
Authors: Santiago Llipsy , Uranga-Murillo Iratxe , Arias Maykel , González-Ramírez Andrés Manuel , Macías-León Javier , Moreo Eduardo , Redrado Sergio , García-García Ana , Taleb Víctor , Lira-Navarrete Erandi , Hurtado-Guerrero Ramón , Aguilo Nacho , del Mar Encabo-Berzosa Maria , Hidalgo Sandra , Galvez Eva M. , Ramirez-Labrada Ariel , de Miguel Diego , Benito Rafael , Miranda Patricia , Fernández Antonio , Domingo José María , Serrano Laura , Yuste Cristina , Villanueva-Saz Sergio , Paño-Pardo José Ramón , Pardo Julián
Published: March 2021

Several hundred millions of people have been diagnosed of coronavirus disease 2019 (COVID-19), causing millions of deaths and a high socioeconomic burden. SARS-CoV-2, the causative agent of COVID-19, induces both specific T- and B-cell responses, being antibodies against the virus detected a few days after infection. Passive immunization with hyperimmune plasma from convalescent patients has been proposed as a potentially useful treatment for COVID-19. Using an in-house quantitative ELISA test, we found that plasma from 177 convalescent donors contained IgG antibodies specific to the spike receptor-binding domain (RBD) of SARS-CoV-2, although at very different concentrations which correlated with previous disease severity and gender. Anti-RBD IgG plasma concentrations significantly correlated with the plasma viral neutralizing activity (VN) against SARS-CoV-2 in vitro. Similar results were found using an independent cohort of serum from 168 convalescent health workers. These results validate an in-house RBD IgG ELISA test in a large cohort of COVID-19 convalescent patients and indicate that plasma from all convalescent donors does not contain a high enough amount of anti-SARS-CoV-2-RBD neutralizing IgG to prevent SARS-CoV-2 infection in vitro. The use of quantitative anti-RBD IgG detection systems might help to predict the efficacy of the passive immunization using plasma from patients recovered from SARS-CoV-2.
Effect of Computer-Aided Navigation Techniques on the Accuracy of Endodontic Access Cavities: A Systematic Review and Meta-Analysis
Authors: Zubizarreta-Macho Álvaro , Valle Castaño Sara , Montiel-Company José María , Mena-Álvarez Jesús
Published: March 2021

The present systematic review and meta-analysis aims to determine the effect of computer-aided navigation techniques on the accuracy of endodontic access cavities. Materials and methods: A systematic literature review and meta-analysis of clinical studies, based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations, was performed that evaluated the root canal location rate of computer-aided navigation techniques applied to endodontic access cavities. Four different databases were used to consult the literature: PubMed-Medline, Scopus, Cochrane, and Web of Science. After discarding duplicate articles and applying inclusion criteria, 14 articles were selected for qualitative analysis and 13 for quantitative analysis. Results: the root canal location success rate started at 98.1% (CI: 95.7–100%) of the cases performed through a computer-aided navigation technique. The prediction interval ranged from 93.3% to 100%. The meta-analysis did not detect heterogeneity between the combined studies (Q-test = 17.3; p = 0.185; I2 = 25%). No statistically significant differences were found between computer-aided static navigation techniques (success rate: 98.5%) and computer-aided dynamic navigation techniques (success rate: 94.5%) (Q test = 0.57; p = 0.451), nor between in vitro studies (success rate: 96.2%) and in vivo studies (success rate: 100%) (Q test = 2.53; p-value = 0.112). An odds success ratio of 13.1 (CI: 95%; 3.48, 49.1) encourages the use of computer-aided navigation techniques over conventional endodontic access cavity procedures. Conclusions: the endodontic access cavities created using static and dynamic computer-aided navigation techniques are highly accurate in locating the root canal system.
Multi-Omics Data Analysis Uncovers Molecular Networks and Gene Regulators for Metabolic Biomarkers
Authors: Jung Su Yon
Published: March 2021

The insulin-like growth factors (IGFs)/insulin resistance (IR) axis is the major metabolic hormonal pathway mediating the biologic mechanism of several complex human diseases, including type 2 diabetes (T2DM) and cancers. The genomewide association study (GWAS)-based approach has neither fully characterized the phenotype variation nor provided a comprehensive understanding of the regulatory biologic mechanisms. We applied systematic genomics to integrate our previous GWAS data for IGF-I and IR with multi-omics datasets, e.g., whole-blood expression quantitative loci, molecular pathways, and gene network, to capture the full range of genetic functionalities associated with IGF-I/IR and key drivers (KDs) in gene-regulatory networks. We identified both shared (e.g., T2DM, lipid metabolism, and estimated glomerular filtration signaling) and IR-specific (e.g., mechanistic target of rapamycin, phosphoinositide 3-kinases, and erb-b2 receptor tyrosine kinase 4 signaling) molecular biologic processes of IGF-I/IR axis regulation. Next, by using tissue-specific gene–gene interaction networks, we identified both well-established (e.g., IRS1 and IGF1R) and novel (e.g., AKT1, HRAS, and JAK1) KDs in the IGF-I/IR-associated subnetworks. Our results, if validated in additional genomic studies, may provide robust, comprehensive insights into the mechanisms of IGF-I/IR regulation and highlight potential novel genetic targets as preventive and therapeutic strategies for the associated diseases, e.g., T2DM and cancers.
Broad Reactivity Single Domain Antibodies against Influenza Virus and Their Applications to Vaccine Potency Testing and Immunotherapy
Authors: Tung Yep Andrew , Takeuchi Yasu , Engelhardt Othmar G. , Hufton Simon E.
Published: March 2021

The antigenic variability of influenza presents many challenges to the development of vaccines and immunotherapeutics. However, it is apparent that there are epitopes on the virus that have evolved to remain largely constant due to their functional importance. These more conserved regions are often hidden and difficult to access by the human immune system but recent efforts have shown that these may be the Achilles heel of the virus through development and delivery of appropriate biological drugs. Amongst these, single domain antibodies (sdAbs) are equipped to target these vulnerabilities of the influenza virus due to their preference for concave epitopes on protein surfaces, their small size, flexible reformatting and high stability. Single domain antibodies are well placed to provide a new generation of robust analytical reagents and therapeutics to support the constant efforts to keep influenza in check.
Testosterone in Female Depression: A Meta-Analysis and Mendelian Randomization Study
Authors: Maharjan Dhruba Tara , Syed Ali Alamdar Shah , Lin Guan Ning , Ying Weihai
Published: March 2021

Testosterone’s role in female depression is not well understood, with studies reporting conflicting results. Here, we use meta-analytical and Mendelian randomization techniques to determine whether serum testosterone levels differ between depressed and healthy women and whether such a relationship is casual. Our meta-analysis shows a significant association between absolute serum testosterone levels and female depression, which remains true for the premenopausal group while achieving borderline significance in the postmenopausal group. The results from our Mendelian randomization analysis failed to show any causal relationship between testosterone and depression. Our results show that women with depression do indeed display significantly different serum levels of testosterone. However, the directions of the effect of this relationship are conflicting and may be due to menopausal status. Since our Mendelian randomization analysis was insignificant, the difference in testosterone levels between healthy and depressed women is most likely a manifestation of the disease itself. Further studies could be carried out to leverage this newfound insight into better diagnostic capabilities culminating in early intervention in female depression.
An Overarching Review on Delay Analyses in Construction Projects
Authors: Çevikbaş Murat , Işık Zeynep
Published: March 2021

Numerous studies have been conducted by researchers on the delay analysis topic, which is one of the primary areas of scientific study due to the effects of delays on time and cost in construction projects. Following fruitful contributions made by the researchers, it is believed to be extremely important to summarize the existing studies in terms of being a road map for future studies and practitioners. In this context, not only does this study aim to detect the most significant authors, sources, organizations and countries contributing to the improvement of delay domain in the construction industry concerning delay analyses worldwide but also to provide the researchers with extensive insights concerning the prominent research themes, trends and gaps in the literature. Hence, 168 documents related to delay analyses from 1982 to 11 February 2021 were detected through the Scopus Database and the Web of Science Database, and scientometric analyses were conducted via VOSviewer software. By evaluating the related research, two main research areas were detected in this field, namely; improving the delay analysis methods and resolving the disputes before they occur. This study is believed to make theoretical and practical contributions in that it examines the delay analysis topic in all aspects such as prominent institutions, countries, authors and sources, synthesizes the data and highlights possible research domains, gaps and trends concerning the delay analysis topic in construction industry.
Functionalization of Ruthenium Olefin-Metathesis Catalysts for Interdisciplinary Studies in Chemistry and Biology
Authors: Matsuo Takashi
Published: March 2021

Hoveyda–Grubbs-type complexes, ruthenium catalysts for olefin metathesis, have gained increased interest as a research target in the interdisciplinary research fields of chemistry and biology because of their high functional group selectivity in olefin metathesis reactions and stabilities in aqueous media. This review article introduces the application of designed Hoveyda–Grubbs-type complexes for bio-relevant studies including the construction of hybrid olefin metathesis biocatalysts and the development of in-vivo olefin metathesis reactions. As a noticeable issue in the employment of Hoveyda–Grubbs-type complexes in aqueous media, the influence of water on the catalytic activities of the complexes and strategies to overcome the problems resulting from the water effects are also discussed. In connection to the structural effects of protein structures on the reactivities of Hoveyda–Grubbs-type complexes included in the protein, the regulation of metathesis activities through second-coordination sphere effect is presented, demonstrating that the reactivities of Hoveyda–Grubbs-type complexes are controllable by the structural modification of the complexes at outer-sphere parts. Finally, as a new-type reaction based on the ruthenium-olefin specific interaction, a recent finding on the ruthenium complex transfer reaction between Hoveyda–Grubbs-type complexes and biomolecules is introduced.
Catalytic Deactivation of HY Zeolites in the Dehydration of Glycerol to Acrolein
Authors: Pala-Rosas Israel , Contreras José L. , Salmones José , Zeifert Beatriz , López-Medina Ricardo , Navarrete-Bolaños Juan , Hernández-Ramírez Sofía , Pérez-Cabrera Jennipher , Fragoso-Montes de Oca Andrés A.
Published: March 2021

The study of the deactivation of HY zeolites in the dehydration reaction of glycerol to acrolein has represented a challenge for the design of new catalysts. HY zeolites with SiO2/Al2O3 molar ratios between 3.5 and 80 were studied. The solids were characterized by XRD, N2 physisorption, SEM-EDXS, Raman and UV-vis spectroscopies, infrared spectroscopy of pyridine (FTIR-Py) and catalytic activity tests from 250 °C to 325 °C. It was found that the total amount of acid sites per unit area of catalyst decreased as the SiO2/Al2O3 molar ratio increased from 3.5 to 80, resulting in the decrease in the initial glycerol conversion. The initial acrolein selectivity was promoted with the increase of the Brønsted/Lewis acid sites ratio at any reaction temperature. The deactivation tests showed that the catalyst lifetime depended on the pore structure, improving with the presence of large surface areas as evidenced by the deactivation rate constants. The characterization of the deactivated catalysts by XRD, N2 physisorption and thermogravimetric analysis indicated that the deposition of coke resulted in the total obstruction of micropores and the partial blockage of mesopores. Moreover, the presence of large mesopores and surface areas allowed the amount of coke deposited at the catalyst surface to be reduced.
Preparation and Performance of Cerium-Based Catalysts for Selective Catalytic Reduction of Nitrogen Oxides: A Critical Review
Authors: Cai Ming , Bian Xue , Xie Feng , Wu Wenyuan , Cen Peng
Published: March 2021

Selective catalytic reduction of nitrogen oxides with NH3 (NH3-SCR) is still the most commonly used control technology for nitrogen oxides emission. Specifically, the application of rare earth materials has become more and more extensive. CeO2 was widely developed in NH3-SCR reaction due to its good redox performance, proper surface acidity and abundant resource reserves. Therefore, a large number of papers in the literature have described the research of cerium-based catalysts. This review critically summarized the development of the different components of cerium-based catalysts, and characterized the preparation methods, the catalytic performance and reaction mechanisms of the cerium-based catalysts for NH3-SCR. The purpose of this review is to highlight: (1) the modification effect of the various metal elements for cerium-based catalysts; (2) various synthesis methods of the cerium-based catalysts; and (3) the physicochemical properties of the various catalysts and clarify their relations to catalytic performances, particularly in the presence of SO2 and H2O. Finally, we hope that this work can give timely technical guidance and valuable insights for the applications of NH3-SCR in the field of NOx control.
Thermochemical Energy Storage Performance Analysis of (Fe,Co,Mn)Ox Mixed Metal Oxides
Authors: Dessie Yabibal Getahun , Hong Qi , Lougou Bachirou Guene , Zhang Juqi , Jiang Boshu , Anees Junaid , Tegegne Eyale Bayable
Published: March 2021

Metal oxide materials are known for their ability to store thermochemical energy through reversible redox reactions. Metal oxides provide a new category of materials with exceptional performance in terms of thermochemical energy storage, reaction stability and oxygen-exchange and uptake capabilities. However, these characteristics are predicated on the right combination of the metal oxide candidates. In this study, metal oxide materials consisting of pure oxides, like cobalt(II) oxide, manganese(II) oxide, and iron(II, III) oxide (Fe3O4), and mixed oxides, such as (100 wt.% CoO, 100 wt.% Fe3O4, 100 wt.% CoO, 25 wt.% MnO + 75 wt.% CoO, 75 wt.% MnO + 25 wt.% CoO) and 50 wt.% MnO + 50.wt.% CoO), which was subjected to a two-cycle redox reaction, was proposed. The various mixtures of metal oxide catalysts proposed were investigated through the thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), energy dispersive X-ray (EDS), and scanning electron microscopy (SEM) analyses. The effect of argon (Ar) and oxygen (O2) at different gas flow rates (20, 30, and 50 mL/min) and temperature at thermal charging step and thermal discharging step (30–1400 °C) during the redox reaction were investigated. It was revealed that on the overall, 50 wt.% MnO + 50 wt.% CoO oxide had the most stable thermal stability and oxygen exchange to uptake ratio (0.83 and 0.99 at first and second redox reaction cycles, respectively). In addition, 30 mL/min Ar–20 mL/min O2 gas flow rate further increased the proposed (Fe,Co,Mn)Ox mixed oxide catalyst’s cyclic stability and oxygen uptake ratio. SEM revealed that the proposed (Fe,Co,Mn)Ox material had a smooth surface and consisted of polygonal-shaped structures. Thus, the proposed metallic oxide material can effectively be utilized for high-density thermochemical energy storage purposes. This study is of relevance to the power engineering industry and academia.
Intratumor Regulatory Noncytotoxic NK Cells in Patients with Hepatocellular Carcinoma
Authors: Zecca Alessandra , Barili Valeria , Rizzo Danila , Olivani Andrea , Biasini Elisabetta , Laccabue Diletta , Dalla Valle Raffaele , Ferrari Carlo , Cariani Elisabetta , Missale Gabriele
Published: March 2021

Previous studies support the role of natural killer (NK) cells in controlling hepatocellular carcinoma (HCC) progression. However, ambiguity remains about the multiplicity and the role of different NK cell subsets, as a pro-oncogenic function has been suggested. We performed phenotypic and functional characterization of NK cells infiltrating HCC, with the corresponding nontumorous tissue and liver from patients undergoing liver resection for colorectal liver metastasis used as controls. We identified a reduced number of NK cells in tumors with higher frequency of CD56BRIGHTCD16− NK cells associated with higher expression of NKG2A, NKp44, and NKp30 and downregulation of NKG2D. Liver-resident (CXCR6+) NK cells were reduced in the tumors where T-bethiEomeslo expression was predominant. HCCs showed higher expression of CD49a with particular enrichment in CD49a+Eomes+ NK cells, a subset typically represented in the decidua and playing a proangiogenic function. Functional analysis showed reduced TNF-α production along with impaired cytotoxic capacity that was inversely related to CXCR6−, T-bethiEomeslo, and CD49a+Eomes+ NK cells. In conclusion, we identified a subset of NK cells infiltrating HCC, including non-liver-resident cells that coexpressed CD49a and Eomes and showed reduced cytotoxic potential. This NK cell subset likely plays a regulatory role in proangiogenic function.
An Uncommon Case of Secondary Organizing Pneumonia Due to Influenza Type B
Authors: Shah Parth , Sobash Philip T. , Vedala Krishna , Kakkera Krishna , Kamoga Gilbert-Roy
Published: March 2021

Secondary organizing pneumonia refers to a disease process caused by pulmonary tissue injury. Various insults can cause secondary organizing pneumonia, including multiple types of infections and cancer. The mainstay of diagnosis is a combination of imaging and lung biopsy showing inflammatory changes, specifically plugs with granulated tissue and fibrosis. Clinical suspicion needs to be raised for secondary organizing pneumonia when a patient is requiring increasing amounts of oxygen in the presence of treatment for pneumonia or another underlying lung disease. Here, we present the case of a 65-year-old male who presented with acute hypoxemic respiratory failure in the setting of previously having been tested positive for influenza B. Aggressive steroids with eventual tapering of his O2 requirements led to a successful outcome. While influenza has been reported as a cause of secondary organizing pneumonia after proceeding infection, these cases are usually represented by type A, rather than B.
Titanium Meshes in Guided Bone Regeneration: A Systematic Review
Authors: Aceves-Argemí Ricard , Roca-Millan Elisabet , González-Navarro Beatriz , Marí-Roig Antonio , Velasco-Ortega Eugenio , López-López José
Published: March 2021

The presence of satisfactory bone volume is fundamental for the achievement of osseointegration. This systematic review aims to analyse the use of titanium meshes in guided bone regeneration in terms of bone gain, survival and success rates of implants, and percentages of exposure. An electronic search was conducted Articles were selected from databases in MEDLINE (PubMed), SCOPUS, Scielo, and Cochrane Library databases to identify studies in which bone regeneration was performed through particulate bone and the use of titanium meshes. Twenty-one studies were included in the review. In total, 382 patients, 416 titanium meshes, and 709 implants were evaluated. The average bone gain was 4.3 mm in horizontal width and 4.11 mm in vertical height. The mesh exposure was highly prevalent (28%). The survival rate of 145 simultaneous implants was 99.5%; the survival rate of 507 delayed implants was 99%. The success rate of 105 simultaneous implants was 97%; the success rate of 285 delayed implants was 95.1%. The clinical studies currently available in the literature have shown the predictability of this technique. It has a high risk of soft tissue dehiscence and membrane exposure although the optimal management of membrane exposition permits obtaining a sufficient bone regeneration volume and prevents compromising the final treatment outcome.
Nonvolatile Ternary Resistive Memory Performance of a Benzothiadiazole-Based Donor–Acceptor Material on ITO-Coated Glass
Authors: Li Yang , Zhang Cheng , Shi Zhiming , Li Jingni , Qian Qingyun , Ling Songtao , Zhang Yufen , Zhu Xiaolin , Wu Xingzhi , Zhang Jinlei , Zhao Run , Jiang Yucheng , Zhang Qijian , Ma Chunlan
Published: March 2021

The explosive growth of data and information has increasingly motivated scientific and technological endeavors toward ultra-high-density data storage (UHDDS) applications. Herein, a donor−acceptor (D–A) type small conjugated molecule containing benzothiadiazole (BT) is prepared (NIBTCN), which demonstrates multilevel resistive memory behavior and holds considerable promise for implementing the target of UHDDS. The as-prepared device presents distinct current ratios of 105.2/103.2/1, low threshold voltages of −1.90 V and −3.85 V, and satisfactory reproducibility beyond 60%, which suggests reliable device performance. This work represents a favorable step toward further development of highly-efficient D–A molecular systems, which opens more opportunities for achieving high performance multilevel memory materials and devices.
Wear and Friction Characteristics of 65Mn Steel for Spike-Tooth Harrow
Authors: Lu Zhiguo , Du Chuanyu , Chen Qingcai , Niu Tianying , Wang Na , Song Wanli
Published: March 2021

The friction and wear characteristics of spike-tooth material (65Mn steel) of Spike-Tooth Harrow in a two-stage peanut harvester were studied in this paper. The friction and wear tests of pin and disc on 65 manganese steel were carried out on the tribometer, then the wear loss and the friction coefficient were studied. The wear loss of the pin was acquired by calculating the mass of the pin before and after the experiment using an electronic balance. According to the actual working environment of peanut spring-finger, four variable parameters are set up: load, speed, soil moisture and soil type. The friction and wear characteristics of pins were studied under different loads, speeds and different soil environments. After wearing, the worn surface of the material was observed by scanning microscope and the wear mechanism was studied. The experimental results show that the wear of the pin increases with the increase of load and decreases with the increase of rotational speed in the same rotation number. Especially in the case of the sandy soil with 20% in moisture, a maximum wear loss of the pin is achieved.
A Probabilistic Method for Estimating the Influence of Corrosion on the CuAlNi Shape Memory Alloy in Different Marine Environments
Authors: Ivošević Špiro , Kovač Nataša , Vastag Gyöngyi , Majerič Peter , Rudolf Rebeka
Published: March 2021

This paper gives an approach to the probabilistic percent corrosion depth estimation model for the CuAlNi Shape Memory Alloy (SMA) in different marine environments. Real testing was performed for validation of the theoretical model, where CuAlNi SMAs were exposed to 6 and 12 months in different seawater environments. Focus Ion Beam (FIB) analysis was used to measure the real corrosion depth on the surfaces of tested samples. A statistical approach to the investigation of the corrosion rate of CuAlNi SMA is given, where the corrosion rate is observed as a continuous random variable described by a linear corrosion model, with the assumption that corrosion starts immediately upon alloy surfaces being exposed to the influences of the marine environment. The three best-fitted two-parameter distributions for estimating the cumulative density function and the probability density function of the random variable were obtained by applying adequate statistical tests. Furthermore, using EDX analyses, we identified the chemical composition of the corroded materials, and with the help of Principal Component Analyses, we determined which corrosion environment had the most dominant influence on the corrosion process. The research results indicated that the changeable environment in the tides had a more heterogenic chemical content, which accelerated the corrosion rate.
Measuring the Realtime Capability of Parallel-Discrete-Event-Simulations
Authors: Obermaier Christina , Riebl Raphael , Al-Bayatti Ali H. , Khan Sarmadullah , Facchi Christian
Published: March 2021

Speeding up Discrete Event Simulations (DESs) is a broad research field. Promising Parallel Discrete Event Simulation (PDES) approaches with optimistic and conservative synchronisation schemes have emerged throughout the years. However, in the area of real-time simulation, PDESs are rarely considered. This is caused by the complex problem of fitting parallel executed DES models to a real-time clock. Hence, this paper gives an extensive review of existing conservative and optimistic synchronisation schemes for PDESs. It introduces a metric to compare their real-time capabilities to determine whether they can be used for soft or firm real-time simulation. Examples are given on how to apply this metric to evaluate PDESs using synthetic and real-world examples. The results of the investigation reveal that no final answer can be given if PDESs can be used for soft or firm real-time simulation as they are. However, boundary conditions were defined, which allow a use-case specific evaluation of the real-time capabilities of a certain parallel executed DES. Using this in-depth knowledge and can lead to predictability of the real-time behaviour of a simulation run.
Adaptive Neural Network Control with Fuzzy Compensation for Upper Limb Exoskeleton in Active Spacesuit
Authors: Li Zhaoyang , Dai Yuehong , Tang Peng
Published: March 2021

In order to meet the maneuverability requirements of spacesuits for future manned planetary exploration, the concept of an active spacesuit based on the joint-assisted exoskeleton technology is presented. First, by studying the kinematic characteristics of the operator wearing the simulated spacesuit in different gravity environments, we developed a prototype of the upper limb exoskeleton. Then, the resistance moment of the simulated spacesuit was roughly obtained to match the operator’s motion range, being utilized to design the resistance moment model. Considering the unknown resistance moment effects in the active spacesuit and the uncertainties of the exoskeleton’s dynamics model, an adaptive neural network control with fuzzy compensation was developed to drive the upper limb exoskeleton’s tracking desired trajectories. Experimental studies were carried out using an upper limb exoskeleton to illustrate that the proposed method has excellent trajectory tracking performance and good adaptive ability to the gravity environment changes.
Numerical Study on the Cavitation Flow and Its Effect on the Structural Integrity of Multi-Stage Orifice
Authors: Lee Gonghee , Jhung Myungjo , Bae Juneho , Kang Soonho
Published: March 2021

Flow leakage due to cavitation erosion occurred at the socket welding part downstream of the multi-stage orifice installed in the auxiliary feedwater (AFW) pump recirculation line of the domestic nuclear power plant (NPP). To assess the adequacy of the changed operating flow rate proposed by a domestic NPP operator as the corrective measure concerning the flow leakage in the AFW pump recirculation line, the pattern of the cavitation flow in the eight-stage orifice and the connecting pipe depending on the magnitude of the operating flow rate was predicted by using ANSYS CFX R19.1. Additionally, using ANSYS Mechanical, the structural analysis was conducted under the same operating flow rate condition used for the flow analysis, and the structural integrity was evaluated for the allowable stress. Based on the flow analysis results, it was found that the operating flow rate was the main factor to influence the cavitation behavior inside the multi-stage orifice, and cavitation flow still happened even in the vicinity of the corrected operating flow rate, so it should be necessary to fundamentally review the adequacy of the multi-stage orifice design. On the other hand, the geometric dimensions and arrangement of orifice hole position at the individual stage of the multi-stage orifice may have a significant influence on the characteristics of pressure drop and flow patterns (including cavitation). Therefore, these effects were examined by simulating an analysis model in which the hole diameter of the eighth-stage orifice was changed under the design flow rate condition. As a result of flow analysis, it was found that reducing the hole diameter in the eighth stage orifice resulted in increasing the pressure drop. In relation to the structural integrity of the eight-stage orifice and the connecting pipe, it was found that its integrity could be maintained under the design and operating flow rate conditions.