bluuebunny/crossref_metadata_2025 huggingface dataset:
Improved Naive Bayesian Classifier for Financial Risks of Listed Companies
Authors: Xu Yuxi , He Yueqiu , Hua Rui , Xu Jingyong
Published: May 2023

In view of the deficiency of naive Bayesian classifier in the assumption of attribute independence, this paper constructs AdaBoost-naive Bayesian classification model to improve the accuracy of the classifier through continuous machine learning. Through data simulation, it is found that with the increase of sample size, the fluctuation gradually decreases, the accuracy reaches more than 99%, and the trend is stable. When the sample attribute is less than 400, the correct rate of the model reaches more than 95%, and the trend is stable. When the sample attribute is more than 600, the correct rate decreases to about 50%. The fewer classification categories, the higher the correct rate of the model. When the number of classification categories is more than 50, the correct rate is zero. In the empirical analysis on the financial risk rating of listed companies in the cultural industry, the improved naive Bayesian classification algorithm has significantly higher efficiency than naive Bayesian classification algorithm, and the model is more sensitive to samples with higher financial risk. The empirical analysis shows that the improved naive Bayesian classifier has higher accuracy and reliability. Through robustness analysis, it is also found that the improved naive Bayesian model has strong robustness.
Influence of Comorbid Obsessive-Compulsive Symptoms on Subjective Cognitive Symptoms in Patients with Major Depressive Disorder
Authors: Wang Chong-Ze , Xie Qing-fang , Zhang Yao , Meng Mei-Ling , Lu Jia-Jing , Li Xin , Lu Dao-Feng , Chu Min-Yi , Lv Qin-Yu , Yi Zhenghui , Wu Haisu
Published: May 2023

Background: Many clinical studies have shown that patients with major depressive disorder (MDD) or obsessive-compulsive disorder (OCD) display evident cognitive deficits. However, little is known about the impact of these disorders on cognitive symptoms.
Methods: This cross-sectional study was conducted with a convenience sampling method to distribute QR codes as an outpatient service. The Patient Health Questionnaire-9 (PHQ-9) assessed for depressive symptoms, and those with a total score ≥ 5 were selected for the analysis. A total of 218 outpatients with MDD were included. The Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) was used for OCS. MDD patients with a Y-BOCS score ≥ 6 were classified as MDD with comorbid OCS (MDDOC). The Perceived Deficits Questionnaire-Depression (PDQ-D-5) was used to evaluate subjective cognitive symptoms. A multivariate analysis of covariance and regression models was performed to estimate the effects of OCS on cognitive symptoms.
Results: There was no significant difference in cognitive symptoms between MDD alone and MDDOC patients (p＞0.05). In the MDDOC subgroup, both the Y-BOCS score and the subdomain (obsession/compulsion) had significant correlations with the PDQ-5 score (r=0.510, 0.504, 0.428, all p＜0.01, respectively). Further hierarchical regression analyses showed that OCS or the OCS subdomain (compulsion/obsession) contributed to cognitive symptoms (all p﹤0.05), even when controlling for depression severity (p＜0.001; p=0.032; p=0.012, respectively). Moreover,mediation anallysis indicated the ralation between PHQ-9 and subjective cognitive sympton was mediated by OCS.
Conclusions: Our findings suggest there is no significant difference in cognitive symptoms between the MDD alone and the MDDOC groups. However, OCS or OCS subdomain may contribute to subjective cognitive symptoms in MDDOC patients. Notably, when controlling for the severity of depression, comorbid OCS aggravated cognition impairment in the MDDOC group.
Increased expression of Neprilysin is associated with inflammation in Preeclampsia
Authors: Atta Sara , Mekky Rehab , Ibrahim Mostafa , Radwan Eman , Abdallah Mohamed Mahmoud
Published: May 2023

Background
Preeclampsia (PE) is associated with a finely tuned equilibrium between trophoblast cell invasion and fetal-maternal immunological tolerance. An imbalance between pro-inflammatory (IL-6) and anti-inflammatory (IL-10) cytokines is a hallmark of PE. Furthermore, Neprilysin (NEP), a membrane-bound metalloprotease (MME), is vulnerable to an inflammatory environment, a crucial component of PE and plays a significant role in modulating vascular tone.
Objectives
to determine the correlation between NEP (mRNA and protein) level and inflammatory status in patients with preeclampsia compared with healthy pregnant. Identify the role of NEP in evaluating the severity of preeclampsia as well.
Methods
52 pregnant women with preeclampsia were the study group, and 52 pregnant women with normo-tension were the control group. After a caesarean section, placental tissue samples from patients and controls were collected to measure the expression levels of mRNA for IL-6, TGF-, IL-10, and NEP. An enzyme-linked immunosorbent assay was used to check the quantity of NEP protein in the blood samples that were obtained. Prism Graph-Pad Software 5.03 was used to conduct the statistical analysis.
Results
Our research revealed a significant positive correlation among NEP (mRNA and protein) and proinflammatory markers (IL-6, TGF-) levels in patients compared to controls and a significant inverse correlation between NEP and anti-inflammatory cytokines (IL-10). Additionally, this is the first study to find a strong positive correlation between NEP level and preeclampsia severity.
Conclusion
In PE patients, there is a substantial relationship between NEP and the degree of inflammation. Additionally, NEP inhibitors can be used to treat PE and improve prognosis.
Reproducibility and dietary correlates of plasma polyphenols in the JPHC-NEXT Protocol Area study
Authors: Murphy Neil , Sawada Norie , Achaintre David , Yamaji Taiki , Scalbert Augustin , Ishihara Junko , Takachi Ribeka , Nakamura Kazutoshi , Tanaka Junta , Iwasaki Motoki , Iso Hiroyasu , Inoue Manami , Gunter Marc , Tsugane Shoichiro , Mori Nagisa
Published: May 2023

Background In recent years, an increasing number of epidemiological studies have suggested a role of polyphenols in the prevention of chronic diseases. Prospective cohort studies have typically measured polyphenol concentrations in a single blood sample and the reproducibility of plasma polyphenol measurements is largely unknown.Objective We evaluated the reproducibility of 35 plasma polyphenols collected at an interval of 1-year. We also examined correlations of these polyphenols with food group intakes calculated from weighed food records (WFR) and food frequency questionnaire (FFQ).Methods The study included 227 middle-aged participants from the JPHC-NEXT Protocol Area in Japan. We measured 35 polyphenols in plasma collected at two points 1-year apart. Food group intakes were calculated from 12-day WFR and FFQ. For the reproducibility analysis, the intraclass correlation coefficient (ICC) of 35 polyphenol concentrations were examined between the two points. Pearson’s partial correlations was used to assess the correlation between polyphenols and food groups.Results Highest ICCs were observed for enterodiol and tea-originated polyphenols - such as gallic acid, quercetin, epigallocatechin, and kaempferol - and coffee-derived polyphenols, such as caffeic acid, and ferulic acid. For the dietary analyses, moderate correlations were observed for non-alcoholic beverages intake and epigallocatechin, epicatechin, catechin, and gallic acid. For green tea, higher correlations were observed with these polyphenols.Conclusion Plasma concentrations of tea and coffee related polyphenols had good reproducibility over a 1-year period. The correlations between intake of non-alcoholic beverages, particularly green tea, and tea polyphenols, indicated moderate- to high correlations.
The process of spatial frequency information in temporal synchrony perception for audiovisual stimuli
Authors: Takeshima Yasuhiro
Published: May 2023

Temporal synchrony is also important for audiovisual integration. The process of temporal synchrony perception is affected by the temporal information provided by each sensory stimulus. Previous studies have shown that spatial frequency (SF) of visual stimuli alters the perceived timing of subjective simultaneity. However, these studies have been limited to the effects of a single SF component. This study measured and compared the points of subjective simultaneity (PSS) for audiovisual stimuli among low, high, and composited SF components. This experiment utilized a dual-presentation timing task and a ternary response format to eliminate response bias for simultaneity judgment. The results indicated that the PSS of the composition-SF stimuli was between that of the low- and high-SF stimuli. The correlation coefficients showed that the PSS of composition-SF stimuli approximated that of low-SF stimuli better than that in high-SF stimuli. Furthermore, this study more directly indicated that the difference of processing speed with SF modulated PSS values. Future studies are necessary to confirm these findings via visual stimuli with a wider range of SF components.
Wnt/β-catenin pathway is a key signaling pathway to trastuzumab resistance in gastric cancer cells
Authors: Kim Yuna , Bae Yoo Jin , Kim Jie-Hyun , Kim Hyunki , Shin Su-Jin , Jung Da Hyun , Park Hyojin
Published: May 2023

Backgroud:
Trastuzumab is the only approved target agent for the first-line treatment of human epidermal growth factor receptor-2 (HER-2) positive gastric cancer; however, trastuzumab resistance is a major problem in clinical practice. To comprehend the mechanism of trastuzumab resistance, we focused on the Wnt/β-catenin signaling pathway and its influence on the phenotypes and behavior of trastuzumab-resistant gastric cancer cells.
Methods
Trastuzumab-resistant NCI-N87R cells were established in vitro from the human gastric cancer cell line NCI-N87 by dose-escalating repeated trastuzumab treatment. We investigated the phenotypes of NCI-N87R cells, including Wnt signaling pathway activity. Gastric cancer organoid cells were incubated with complete medium and Wnt3a-depletion medium, and their resistance to trastuzumab was compared.
Results
NCI-N87R exhibited stemness and epithelial-mesenchymal transition (EMT)-like phenotypes, along with decreased levels of the epithelial marker E-cadherin and increased levels of the mesenchymal markers Vimentin and Snail along with an increased Wnt signaling pathway activity. When gastric cancer cells were incubated in Wnt3a-conditioned medium. Wnt signaling pathway activity and resistance to trastuzumab increased. Gastric cancer patient-derived organoids incubated in Wnt3a-depletion medium were more susceptible to dose-dependent inhibition of cell viability by trastuzumab than those incubated in complete medium.
Conclusions
Trastuzumab-resistant gastric cancer cells exhibited EMT-like phenotype, and trastuzumab resistance was promoted by the Wnt/β-catenin signaling pathway. The Wnt/β-catenin pathway is a key signaling pathway for trastuzumab resistance in gastric cancer cells.
Alterations in Neuroendocrine Axes in Brain-Dead Patients
Authors: Akbaş Türkay , Öztürk Ayhan
Published: May 2023

Purpose: To identify changes in anterior pituitary gland hormone levels in brain-dead patients, and alterations in free triiodothyronine (fT3), free thyroxine, cortisol, testosterone, and estradiol levels.
Methods: Ten postmenopausal women and 22 men with brain death (BD) were included. The first blood sample for determining hormones (pre-BD) was collected when the clinician observed the first symptoms of BD. The second blood sample (BD day) was drawn after BD certification.
Results: Female patients exhibited lower follicle-stimulating hormone and prolactin levels pre-BD and luteinizing hormone, follicle-stimulating hormone and prolactin levels on BD day than the age-matched controls. Male patients’ sex hormone levels were similar to those of the age-matched controls, except for testosterone levels, which were low in both consecutive measurements. All gonadotropins and prolactin levels were above the tests’ lower detection limits (LDLs), except for one male patient with gonadotropin levels below the LDLs of the tests. Estradiol levels in both sexes ranged from normal to elevated. FT3 levels were significantly decreased in the two measurements. Thyroid-stimulating hormone (TSH) levels were low in eight patients, and all low TSH levels were above the test’s LDL. The remaining patients had normal or elevated TSH levels. The median adrenocorticotropic hormone (ACTH) and cortisol levels were within normal limits. All cortisol and ACTH levels were above the tests’ LDLs, except for one patient with ACTH levels below the LDL in both measurements.
Conclusion: This study supports that the anterior pituitary gland continues functioning in the brain-dead state.
Prevalence and Associated factors of Anxiety symptoms among front-line Health care workers in Tigrai region quarantine and Treatment centers, Southern Ethiopia 2020; Cross-sectional study
Authors: Niguse Gebrezabher , Abreha Zewde , Tsegay Abreha , Rejeu Mehammedseid , Siyum Desta
Published: May 2023

Background Corona virus disease (COVID-19) has caused universal psychological impact around the globe. Healthcare workers are among the many groups of people who are in the frontline and facing a risk of direct exposure to the virus. The purpose of the study was to assess anxiety symptoms and associated factors among health care workers managing COVID-19 in Tigray region quarantine and treatment centers.Methods A Cross-sectional study was conducted on 155 study participants in Tigrai region quarantine and Treatment centers from June 2020 to September 2020. Data were collected using online survey. Binary logistic regression analysis was conducted to identify factors that affect anxiety symptoms. Statistical significance was declared using a p-value < 0.05 and 95% of confidence interval (CI) for an adjusted odds ratio (AOR).Results The study found that the prevalence rate of anxiety symptoms among health care workers was 23.9%. This study also indicated that being gender AOR 2.310:95%CI [1.301–4.641], history of anxiety AOR 0.008:95%CI [0.000-0.144],institutional support AOR 3.244:95%CI [1.930–5.438] were significant predictors of anxiety symptoms among health care workers.Conclusion The prevalence of anxiety symptoms among HCWs in Tigray region during the pandemic is comparable with other countries.
Impact of a training strategy on improving compliance of hand hygiene and gloving during the placement of a short peripheral venous catheter: the multicentre study CleanHand4
Authors: FARIZON Mathilde , SANTOS Sandra DOS , RICHARD Lucas , PETITEAU Agnès , VALENTIN Anne-Sophie , MEE-MARQUET Nathalie VAN DER
Published: May 2023

Background. Patients who have short peripheral venous catheters (PVC) face an elevated risk of developing bloodstream infections. Preventing catheter-related infections relies on implementing multiple measures, including practicing proper hand hygiene (HH) during catheter placement.Methods. We conducted a four-part study : (1) an evaluation of HH practices through direct observation of PVC placements, coupled with the study of the microbial flora of the HCWs fingers just before the placement; (2) the development of an educational tool based on the collected observational and microbiological data; (3) the training to the HCWs observed during the first part, using this tool; and (4) the subsequent observation of the trained HCWs to measure the impact of the training on practice improvement.Results. Compliant HH was observed in 23.5% of the 647 HCWs observed during PVC placement before training. The microbiological study revealed fewer pathogens on the fingertips of the HCWs practicing compliant HH compared other HCWs (2.6 vs 11,7%; p = 0.003). The comparison of practices before and after training, assessed amng 180 HCWs, showed an increase in the proportion of HCWs performing compliant HH (63.2 vs 25.0%; p < 0.001).Conclusions. Training HCWs using our educational tool, which combines reminders of best practices and risk factors associated with PVC-related infections, engaging HCWs (presentation of practice evaluation), identifying professionals deviating from best practices (simulation videos), and objectively assessing fingertip contamination (microbiological study), significantly improved compliance with HH gestures and glove usage. We encourage infection control teams to utilize this tool to raise awareness among HCWs responsible for PVC placement about the risk of infection associated inadequate hand hygiene.
A randomized phase II study of full dose gemcitabine versus reduced dose gemcitabine and nab-paclitaxel in vulnerable patients with non-resectable pancreatic cancer (DPCG-01)
Authors: Rasmussen Louise Skau , Winther Stine B , Chen Inna M , Weber Britta , Ventzel Lise , Liposits Gabor , Johansen Julia Sidenius , Detlefsen Sönke , Egendal Ida , Shim Susy , Christensen Signe , Pfeiffer Per , Ladekarl Morten
Published: May 2023

Background
According to current evidence, the best treatment for fit patients with non-resectable pancreatic cancer (PC) is combination chemotherapy, whereas frail patients are recommended gemcitabine (Gem) monotherapy. Randomized controlled trials in colorectal cancer and a post-hoc analysis of gemcitabine and nab-paclitaxel (GemNab) in PC suggest, however, that reduced dose of combination chemotherapy may be feasible and more efficient compared to monotherapy in frail patients. The aim of this study is to investigate whether reduced dose GemNab is superior to full dose Gem in patients with resectable PC, who are not candidates for full dose combination chemotherapy in first line.
Methods
The Danish Pancreas Cancer Group (DPCG)-01 trial is a national multicenter prospective randomized phase II trial. A total of 100 patients in ECOG performance status 0-2 with non-resectable PC, not candidate for full dose combination chemotherapy in first line, but eligible for full dose Gem, will be included. Patients are randomized 1:1 to either full dose Gem or GemNab in 80% of recommended dose.
The primary endpoint is progression-free survival. Secondary endpoints are overall survival, overall response rate, quality of life, toxicity and rate of hospitalizations during treatment. The correlation between blood inflammatory markers, including YKL-40 and IL-6, circulating tumor DNA, and tissue biomarkers of resistance to chemotherapy and outcome will be explored. Finally, the study will include measures of frailty (G8, modified G8, and chair-stand-test) to assess whether scoring would enable a personalized allocation to different treatments or indicates a possibility for interventions.
Discussion
Single-drug treatment with Gem has for frail patients with non-resectable PC been the main treatment option for more than thirty years, but the impact on outcome is modest. If improved results and sustained tolerability with reduced dose combination chemotherapy can be shown, this could change the future practice for this increasing group of patients.
Trial registration
ClinicalTrials.gov Identifier: NCT05841420.
Secondary Identifying No: N-20210068.
EudraCT No: 2021-005067-52.
Protocol version: 1.5, 16-MAY-2023.
Pink esthetic score with Autogenous Dentin Chips versus Xenograft with Conventional Immediate Implantation in Thin Buccal Bone:(Randomized Controlled clinical trial)
Authors: Hamada cherine , reda ahmed , shoeib mona
Published: May 2023

Objectives: soft tissue in the esthetic zone for an immediate implant Is considered challenging. This study aimed to evaluate soft tissue aesthetics around immediate dental implants with dentin chips and xenograft in thin buccal bone.
Materials and Methods:non-restorable teeth (n=16) were recruited in this study for immediate implant placement with augmentation using dentin chips and xenografts. Patients were randomly assigned into two equal groups (n=8). Pink aesthetic scores are recorded on loading, at 6 months & after 1 year of implant insertion according to Vanlıoğlu. ; buccal, crestal bone resorption was measured using CBCT at months & 1 year and implant stability was measured using osstel twice, and pain was recorded according to Breivik.
Results: Both groups showed better PES after 6 months and 1 year P-value = 0.343; P-value = 0.199; the nearly same level of crestal bone & The buccal bone at 6 months & 1 year; implant stability is better at 6 months and one year P-value = 0.514; P-value = 0.340 and reduction in the post-operative pain within 1 week following implant placement but with statistically a significant difference between both groups.
Conclusions:
The use of autogenous dentin chips proved to be a valid alternative to bone grafting materials to fill the jumping gap in conjunction with immediate implants in the aesthetic zone.
PES, the overall difference between the control and the intervention groups showed no statistical significance.
Clinical relevance :
Autogenous dentin chips may be a good alternative to xenograft with a cost-effectiveness advantage
New characterizations of the ring of the split-complex numbers and the field C of complex numbers and their comparative analyses
Authors: Yadeta Hailu Bikila
Published: May 2023

In this paper, we give a new characterization of the split-complex numbers as a vector space LC2 = {xI + yE : x, y ∈ R, E 2 = I} of operators, where I is the identity operator and E is the unit shift operator that are operating on the space P2 of all real-valued 2-periodic functions. We also characterize the field of the complex number C = {x + yi : x, y ∈ R, i 2 = −1} as the space of linear operators of the form {xI +yE, E 2 = −I}, where I is the identity operator and E the unit shift operator that are regarded as operating on the vector space AP2 of all real-valued 2-antiperiodic functions. In an analogy to the polar form of complex numbers, we form the hyperbolic form of some subset H of the elements of LC2. We study some properties of the elements of LC2, the trace, the determinant, invertibility conditions, and others. We study some elementary functions defined on subsets of LC2 as compared and contrasted with the usual complex functions. We study properties like continuity, differentiability and define the holomorphic condition of LC2 functions in a different sense than complex functions. We establish the line integrals of the vector-valued functions in LC2 and compare them against the well known results for complex functions of a complex variable.
MSC2020: Primary 30A99, 47B38, 47B39, 47B92, 39A23
MSC2020: Secondary 16S90
Fabrication of robust homogeneous braid reinforced CA hollow fiber membranes with enhanced hydrophilicity
Authors: Zhao Wei , jin Xin , Sun Guangwu , Chen Kaikai , Ling Haoyang , Fan Zuwei , Xiao Changfa
Published: May 2023

Cellulose acetate (CA) membrane is usually utilized in wastewater treatment and biomedical process due to its good biocompatibility and easy processing but low flux and poor anti-fouling. The hydrophilicity and anti-fouling property of membrane could be improved through the doping of functional nanoparticles. Herein, the robust homogeneous braid reinforced (HBR) CA hollow fiber membranes with GO doping were fabricated by the continuous skin-core spinning method. The content of GO exhibited noticeable effects on the structure and property of HBR CA hollow fiber membranes. On the one hand, the neatly arranged finger-like pore structure and good permeability could be designed. On the other hand, the high protein rejection and anti-fouling property were obtained. For example, the pure water flux and BSA rejection could be obviously improved from 115.7 L·m-2·h-1 to 201.4 L·m-2·h-1, 97.2% to 99.5% respectively. The optimal GO content was 0.1 wt.% according to the assessment of flux decline coefficient, flux recovery rate and BSA rejection. Moreover, the HBR structure provided favorable interface bonding strength and excellent mechanical strength, which was suitable for the high pressure backwash and aeration process in filtration system. In a word, the HBR CA hollow fiber membrane with good hydrophilicity and anti-fouling property showed potential applications for wastewater treatment and biomedical process.
Low phase noise of concurrent dual-band oscillator with negative resistance
Authors: Afkari Ehsan , Ahmadpour Behrouz , Allahverdi Majid , Bemani Mohammad
Published: May 2023

In this paper, we study the design of dual-band concurrent low phase noise oscillator with negative resistance structure. First, for each frequency band, a single-band negative resistance oscillator is designed separately. A suitable dual-band matching circuit has been used to dual-band these two oscillators so that we can oscillate at both frequencies simultaneously at last oscillator operates concurrently at 2.4GHz and 5.2GHz frequencies separately. Synchronization improves the performance of the oscillator, increases the data transfer speed and reduces the dimensions of the oscillator and also the design method of the oscillator with negative resistance is a simple and low cost method in designing the oscillator. One of the challenges in designing an oscillator is the oscillator's phase noise, the oscillator should ideally have low phase noise. In this oscillator, the simulated phase noise values, at 10MHz offset for the frequencies of 2.4GHz and 5.2GHz are -137.28dBc/Hz and -140.388dBc/Hz,respectively and the amount of output powers are 3.991dBm and 4.583dBm.
Study on the diffusion law of dynamic water grouting in fracture with slurry-rock stress coupling effect
Authors: Liu Yang , Wang Yingchao , Sui Wanghua , Han Lijun
Published: May 2023

Water inrush disasters in geotechnical engineering are mainly caused by seepage in fractures, and curtain grouting is the most common method to block water flow. To ensure the effectiveness of the water blocking curtain, it is necessary to study the diffusion pattern of the slurry. In this study, by means of laboratory experiments and theoretical deductions, the grout diffusion morphology in fractures with the slurry-rock stress coupling effect is revealed, and the corresponding theoretical model is established. First, based on the failure of a water curtain in a hydropower project in Yunnan Province, a four-level four-factor orthogonal table was set up, grouting experiments were conducted by using the self-developed fracture grouting device, and the relationship between the main influencing factors and fracture deformation and grout diffusion distance was revealed by variance analysis. Then, based on the Bingham fluid constitutive model, the fracture deformation equation and the grouting model with flowing water, a new fracture grouting model considering the coupling effect of slurry-rock stress was established. Finally, based on the calculations and experiments, the morphology of slurry diffusion is described, thereby proving the validity of the new model.
FOF: A Fine-Grained Object Detection and Feature Extraction end-to-end Network
Authors: Shen Wenzhong , Chen JinPeng , Shao Jie
Published: May 2023

Currently, widely-used object detection can predict targets present in the training set. However, in fine-grained object detection tasks, such as commodity detection, the introduction of a new target class requires retraining the model, which significantly reduces the flexibility of the algorithm in applications. In response to this problem, we propose an end-to-end fine-grained object detection and feature extraction network(FOF). To detect and identify objects beyond the target category of the training set, the category output in the network Head is removed and replaced with a 128-dimensional feature vector. We used the ArcFace loss function to improve feature classification during training. Since there is no category output, an improved Non-Maximum Suppression(NMS) algorithm, Non-Maximum Suppression-Feature Similarity(NMS-FS), is proposed to distinguish same class and dissimilar class prediction boxes by feature similarity. During the inference, FOF outputs prediction boxes and feature vectors, and matches them with the feature vectors in the feature gallery to determine the detected object category and complete object detection and recognition. Experimental results indicate that FOF achieved high accuracy in both the MS COCO dataset and a large-scale and fine-grained Retail Product Checkout dataset(RPC). In addition, the method exhibits a low Equal Error Rate(EER) when identifying new categories, achieving the objective of detecting and identifying new categories without the need to retrain the model.
The first-ever clinical classification of metastatic spinal malignancies serves as a vital reference to surgical management:a retrospective case-control study
Authors: Bai Junjun , Li Jian , Lv Jia , Yang Wangzhe , Wang Yushan , Lv Zhi , Feng Yi
Published: May 2023

Background: It is commonly accepted that Surgical treatment is an essential component of the comprehensive treatment of metastatic spinal malignancies. However, Up until now, the clinical classification of metastatic spinal malignancies has not been well-structured.
Methods: After IRB approval, 86 patients with metastatic spinal malignancies who underwent therapy at the Second Hospital of Shanxi Medical University between January 2014 and March 2020 were adopted. According to the vascular distribution, stability of vertebrae and the degree of nerve compression, osteolytic metastatic spinal tumors can be classified into five types. 20 of them who did not receive segmental arterial embolization was set as a control group. The standard group included 24 patients who received segmental arterial embolization on both sides of the diseased vertebrae. 42 patients were included in the intervention group after receiving responsible arterial embolization. Surgical intervention was performed within 24 hours following an embolization.
Results: In comparison with the control and standard groups, the intervention group presented unique advantages in terms of bleeding volume (p＜0.001), operating time (p＜0.001), and local recurrence rate within 12 months (p＜0.006).
Conclusion: The promising surgical intervention strategies can be developed according to the new clinical classification of metastatic spinal malignancies.
Exosomes from Adipose-derived stem cells overexpressing microRNA-671-3p promote fat graft angiogenesis and adipogenic differentiation
Authors: Hao Xiaoyan , Guo Yuan , Yu Xueyuan , He Lin , He Youcheng , Shu Maoguo
Published: May 2023

Exosomes from Adipose-derived stem cells (ADSCs) have been demonstrated to benefit angiogenesis, wound healing and fat grafting. Small noncoding RNAs such as microRNA (miRNA) and circular RNA play critical role mediating the function of ADSC-derived exosomes. However, the underlying mechanisms have not been fully elucidated. In this study, we investigated the function and mechanism of ADSC-derived exosome promoting fat graft angiogenesis and adipogenic differentiation. Exosomes from ADSCs were isolated and identified while treatment with ADSC-derived exosomes enhanced fat graft angiogenesis and adipogenic differentiation in mouse fat graft implantation model. We found that ADSC-derived exosome overexpressed miR-671-3p and promoted human umbilical vein endothelial cell (HUVEC) proliferation, migration and invasion. Bioinformatics analysis and luciferase reporter assay validated that TMEM127 was a direct target of miR-671-3p. Rescue experiments demonstrated that overexpression of TMEM127 partially antagonized the function of ADSC-derived exosome in vitro, suppressing HUVEC cell proliferation, migration and invasion. Moreover, overexpression of TMEM127 abrogated the function of ADSC-derived exosome on fat graft angiogenesis and adipogenic differentiation. Taken together, our findings demonstrate that exosomes from ADSC overexpressing miR-671-3p promote fat graft angiogenesis and adipogenic differentiation.
The Relationship Between Work-Related Factors, Risky Behaviors, and Major Accidents Among Motorcycle Food Delivery Riders (MFDR) in Thailand
Authors: Kwangsukstith Siriaran , Surawattanasakul Vithawat , Mahakkanukrauh Chollada , Panumasvivat Jinjuta , Sirikul Wachiranun , Kitro Amornphat
Published: May 2023

Motorcycle food delivery riders (MFDR) are more susceptible to traffic collisions when compared to regular motorcyclists. Their safety is a major concern in many developing countries, especially Thailand, which has the highest rate of motorcyclist fatalities in the world. This cross-sectional study aimed to identify the prevalence of accidents, hospitalization, involvement in risky behaviors, and concerning problems among MFDR and determine factors associated with accidents. The data were collected from 709 MFDR in Chiang Mai, Thailand. The prevalence of any accidents among MFDR in the past six months was 18.9% which can be categorized into 4.9% minor injuries, 2.4% hospitalized major injuries, and 11.6% non-hospitalized major injuries. 84.3% of them engaged in at least one risky behavior and 5.8% of them engaged in ten or more risky behaviors. The most frequent risky behavior was using the mobile phone while riding (78.8%), While the least frequent risky behavior not wearing a helment (9.3%). Multivariable logistic regression analysis indicates that the factors associated with the major accidents were running a red light (aOR 2.78, 95%CI 1.07 to 7.21) and having concerns for customer behavior (aOR 2.66, 95%CI 1.26 to 5.62). The factors associated with any accidents (both major and minor accidents) were sleeping < 6 hours/day (aOR 2.13, 95%CI 1.41 to 3.21) and working ≥ 48 hours/week (aOR 1.72, 95%CI 1.04 to 2.83) To reduce the rate and severity of traffic accidents, the government and the delivery firms should provide effective strategies and targeted interventions focusing on the reduction of risky behaviors and other modifiable risk factors.
Numerical Simulation of Solitary Wave Power Absorption by Rotating Slotted Flappers using Incompressible SPH Method
Authors: Heydari Zohreh , Shobeyri Gholamreza
Published: May 2023

In this study, the incompressible smoothed particle hydrodynamics (ISPH) as a mature enough mesh-less method is applied to simulate the oscillatory motion of different slotted rotating flappers at the end of a numerical tank under the hydrodynamic load of a solitary wave. The solitary wave can be considered a simple model of ocean waves with long-lasting source of eco-friendly and renewable energy. Many engineering devices such as rotating flappers have been proposed and designed to capture this energy. On the other hand, these structures can also be applied to withstand destructive waves for example Tsunami waves with huge potential to cause severe damage to coastal structures and loss of life in shore regions. This study investigates the performance of a number of 2-D rotating bottom-hinged flappers slotted with different patterns representing a new conceptual model of a wave energy absorber device capable of protecting coastal structures. With providing structural facilities, various slotting patterns can be arranged for a single flapper to have appropriate performance for different wave conditions with the lowest construction cost. Based on the obtained numerical results, it has been found that the spring stiffness of the flapper has the most important physical parameter determining the amount of wave power extraction. In addition to this, the spring friction also has a significant effect on the dissipation of the absorbed power. The slotted flappers also show different rotational motion with less captured power in comparison with the solid flapper. Several physical properties such as the slotted area provided in the flapper and the corresponding pattern, the spring stiffness and friction and other related properties must be determined to protect desired structures at the predefined level and capture maximum energy as much as possible. The findings of this research can be used as a preliminary guide to design more realistic 3-D protective flappers for complex flow conditions.
Decreased serum 4-Hydroxynonenal level as a biomarker for the progression of steroid-induced osteonecrosis of the femoral head
Authors: Xiao Fangjun , Wei Tengfei , Tian Jiaqing , Peng Peng , Wei Yurou , Fang Weihua , Xiao Huan , He Mincong , He Wei , Wei Qiushi
Published: May 2023

Background: 4-hydroxynonenal (4-HNE) is a common marker of oxidative stress. this study aim to study the potential role of 4-HNE in the progression of steroid-induced osteonecrosis of the femoral head (SIONFH).
Method: Between April 2021 and December 2021, 64 subjects were enrolled in this cross-sectional case-control study. 36 patients were grouped based on the Association Research Circulation Osseous (ARCO) classification. Bone HE staining, micro-ct, immunohistochemistry, and level of plasma 4-HNE were evaluated. Immunohistochemistry presented that 4-HNE was detected in the trabecular bone, osteocytes, and bone marrow.
Results: Plasma 4-HNE levels were significantly higher in SIONFH patients in the early stage of disease stages (Stage II) , and the 4-HNE level was higher in the SIONFH group than those in the normal control group (P<0.001). The 4-HNE level was negatively associated with ARCO stages (r =- 0.6875, P<0.001).
Conclusion:The level of 4-HNE is negatively associated with ARCO stages. The reduced 4-HNE may be a critical biomarker of the progression of SIONFH.
A patient survey indicates quality of life and progression-free survival as equally important outcome measures in multiple myeloma clinical trials
Authors: Fleischer Anna , Zapf Larissa , Allgaier Johannes , Jordan Karin , Gelbrich Götz , Pryss Rüdiger , Schobel Johannes , Bittrich Max , Einsele Hermann , Kortüm Martin , Maatouk Imad , Weinhold Niels , Rasche Leo
Published: May 2023

Purpose
To investigate the trade-off between survival outcome and quality of life (QoL) in Multiple Myeloma (MM).
Methods
We developed a questionnaire that asked patients amongst others, whether they would choose a shortened time of progression-free survival (PFS) in favor of an increased QoL
Results
Of 194 MM patients who answered this question, 81 (42%) subjects were willing to accept a shorter PFS for better QoL. On the other hand, 92 (47%) preferred a longer PFS at the cost of reduced QoL. Twenty-one patients (11%) indicated to be undecided. Specific features were associated with the two main groups (“in favor QoL” vs “in favor PFS”). Patients who belonged to the “in favor QoL”-group tended to be in more advanced treatment lines when compared to the “in favor PFS-group” (P = 0.0001). Patients who preferred PFS were found to generally be more likely to hand over responsibility to their physicians (P = 0.01). No associations were found for other disease specific conditions including pain, gastrointestinal symptoms, fatigue or infection.
Conclusion
The results of our study highlight significant differences in patients’ preferences, thus underlining the importance of assessing individual patient needs in determining the endpoints of further research.
Machine Learning-Based Privacy Policy Analysis and Visualization for GDPR Compliance
Authors: Ingole Chetan Umesh , Bandela Manav , Tanna Dev N , Solanki Saurav Kumar , Dhotre Prashant , Patil Rajkumar
Published: May 2023

Concerns about online privacy have become more prevalent as a result of the quick spread of internet services. However, customers are frequently presented with lengthy and complicated privacy policy documentation offered by service providers, which prevents them from reading and understanding these policies. In order to overcome this difficulty, this paper suggests a machine learning-based solution that makes it easier to comprehend privacy policies. To develop our method, we sincerely examined the privacy policies of the top 100 Indian-accessible internet services. Whenever a user visits a website, our tool automatically evaluates it and determines if the General Data Protection Regulation (GDPR)'s data protection guidelines are being followed. Users may use these ratings to determine if a certain privacy policy is in compliance with privacy-abiding practices or not. This approach seeks to narrow the knowledge gap between users and privacy policies, promoting informed choice-making and strengthening online privacy protection.
Megahertz X-ray multi-projection imaging
Authors: Villanueva-Perez Pablo , Bellucci Valerio , Zhang Yuhe , Birnšteinová Šarlota , Graceffa Rita , Adriano Luigi , Asimakopoulu Eleni Myrto , Petrov Ilia , Yao Zisheng , Romagnoni Marco , Mazzolari Andrea , Letrun Romain , Kim Chan , Koliyadu Jayanath , Deiter Carsten , Bean Richard , Giovanetti Gabriele , Gellisio Luca , Ritschel Tobias , Mancuso Adrian , Chapman Henry , Meents Alke , Sato Tokushi , Vagovic Patrik
Published: May 2023

X-ray time-resolved tomography is one of the most popular X-ray techniques to probe dynamics in three dimensions (3D). Recent developments in time-resolved tomography opened the possibility of recording kilohertz-rate 3D movies. However, tomography requires rotating the sample with respect to the X-ray beam, which prevents characterization of faster structural dynamics. Here, we present megahertz (MHz) X-ray multi-projection imaging (MHz-XMPI), a technique capable of recording volumetric information at MHz rates and micrometer resolution without scanning the sample. We achieved this by harnessing the unique megahertz pulse structure and intensity of the European X-ray Free-electron Laser with a combination of novel detection and reconstruction approaches that do not require sample rotations. Our approach enables generating multiple X-ray probes that simultaneously record several angular projections for each pulse in the megahertz pulse burst. We provide a proof-of-concept demonstration of the MHz-XMPI technique's capability to probe 4D (3D+time) information on stochastic phenomena and non-reproducible processes three orders of magnitude faster than state-of-the-art time-resolved X-ray tomography, by generating 3D movies of binary droplet collisions. We anticipate that MHz-XMPI will enable in-situ and operando studies that were impossible before, either due to the lack of temporal resolution or because the systems were opaque (such as for MHz imaging based on optical microscopy)
Effect of symptomatic rate on spreading of COVID-19 evaluated by a flexible compartment model
Authors: Ohmori Hiroo
Published: May 2023

For COVID-19, many of the infected individuals become symptomatic after the latent period is ended and should be isolated from the community. After the isolation period is ended, they become the recovered individuals who have immunity and return to the community. Thus, they are capable of infecting susceptible individuals only during the latent period. Some infected individuals, however, are asymptomatic through the recovery period which includes the latent period. They are infectious but not isolated. They stay in the community and continue infecting susceptible individuals through the recovery period, inducing the increase in the number of infected individuals, though they become the recovered individuals who also have immunity in the community after the recovery period is ended. The number of the ‘symptomatic and isolated’ infected individuals and/or of the ‘asymptomatic and staying’ infected individuals is controlled by the symptomatic rate. Thus, the symptomatic rate affects the number of infectious individuals continuing to infect susceptible individuals in the community. At the same time, the symptomatic rate affects the number of isolated individuals and, as a result, the number of recovered individuals and the population excluding the individuals kept in isolation. Since the contact rate between infected individuals and susceptible ones is affected with both the number of recovered individuals having returned to the community and the population excluding the individuals kept in isolation, the symptomatic rate affects the contact rate, too. Namely, the symptomatic rate affects not only the number of infectious individuals but also the contact rate. This symptomatic rate could change commonly depending on the characteristics of virus and/or on the health conditions of infected individuals. However, the symptomatic rate could be changed/decided in the middle of infection duration by political and/or medical interventions, because the symptomatic rate practically means the isolation rate, and the isolation rate and/or the number of isolated individuals could be decided by some political and/or medical interventions induced by such as the capacity of hospital care. Therefore, the evaluation of the effect of the symptomatic rate could give the reference materials for political and/or medical measures. The effects of vaccination and of the isolation by PCR test are also examined for the cases with different symptomatic rates. The results of evaluation by a flexible compartment model, which is a model including the symptomatic rate as a term in the calculation equation and being able to evaluate the effect of the isolated/recovered individuals on spreading of COVID-19, show that a little difference in the symptomatic rate causes a large difference in the number of infected individuals and in the infection duration. Vaccination and PCR test show to be effective on reduction of the number of infected individuals for the cases with any symptomatic rates.
Research to determine the best value of both Z and OVC in micro-EDM using carbon coated electrode using topsis method
Authors: Pham Dong Van
Published: May 2023

In the machining process, it is difficult to solve problems due to the relationship between productivity and quality, for example, as the productivity increases, the quality of reprocessing may decrease. Some methods only address specific objectives, such as the quality of the machining method, the machining productivity, the quality, or even the cost. Electrical discharge machining (EDM) and micro-EDM are most commonly used for processing the surfaces of die and moulds. The amount of electrode wear in micro-EDM has a direct effect on the dimensional accuracy of the machined hole. Therefore, improving the corrosion resistance of electrodes in micro-EDM is still of great interest. The effective coating of thin film for the micro tool electrodes in the case of micro – EDM can lead to minimize the electrode wear which eventually improve the productivity and machining quality. In the present study, experiments were performed on micro – EDM using carbon coated tool electrode and optimized using Taguchi-Topsis to investigate optimum levels of Depth of cut (Z) and overcut (OVC). It was concluded that optimum conditions had improved significantly using carbon coated micro tool electrode. Optimal  levels of technological parameters include V=160 V, C=10000 pF, RPM=400 rpm, and Zopt=2,525 mm, OVCopt=72,856 μmm. The quality of the machined surface with the coated electrode at optimal conditions is analyzed and evaluated. The Topsis method is a suitable solution to this problem, and the steps to perform the calculation in this technique are simple