bluuebunny/crossref_metadata_2025 huggingface dataset:
Endodontic flare-up incidence in pulp necrosis in Universitas Airlangga Dental Hospital (RSKGMP Universitas Airlangga)
Authors: Sampoerno Galih , Zubaidah Nanik , Salsabilla Wanda
Published: November 2022

Background : Dental caries occurs as a result of demineralization of the hard tissues of the teeth followed by the destruction of the organic matter, resulting in bacterial invasion and death of the pulp which can lead to pulp necrosis. One of the treatments for pulp necrosis is endodontic treatment. Endodontic treatment includes root canal preparation techniques, root canal irrigation materials, root canal dressing materials, and also root canal obturation techniques. In endodontic treatment can experience flare-ups. An endodontic flare-up is a pain or swelling after endodontic treatment that occurs in a relatively short time. Purpose : To describe the incidence of endodontic flare-ups in pulp necrosis at RSMKGP Universitas Airlangga. Methods : Conducted descriptive observasional research on patients who had endodontic treatment at UPF Dental Conservation, Dental and Oral Hospital, Faculty of Dental Medicine, Airlangga University in 2018, 2019, and 2020. Results : A total of 28 patients (30,1%) from 93 patients were experience pain or flare-ups after root canal treatment. Conclusion : From the result of this study, it can be concluded that there is still an incidence of endodontic flare-ups in pulp necrosis at RSKGMP Universitas Airlangga which is 30,1%.
Strategi Promosi Tokopedia Dalam Perspektif Hukum Islam
Authors: Janah Fitri Noer , Wahyuningsih Ghina , Pusparini Martini Dwi
Published: November 2022

Tokopedia adalah salah satu marketplaceyang memiliki jumlah pengunjung tertinggi menurut data triwulan III di Indonesia pada tahun 2018. Adapun strategi promosi yang dilakukan oleh Tokopedia yaitu selalu menghadirkan iklan yang sangat menarik bagi costumer dengan berbagai promosi yang disediakan seperti gratis ongkos kirim, diskon besar-besaran dan lainnya. Sebagai costumer tentunya sangat memperhatikan promosi agar dapat menghemat anggaran pengeluaran, namun tetap mendapatkan barang yang berkualitas.Tujuan strategi promosi Tokopedia yaitu agar dapat menjalin kepercayaan (transloyalty) dengan costumer dan mitra sehingga mereka mengetahui bahwa Tokopedia merupakan e-commerce yang dapat dipercaya. Di sisi lain, tujuan hadirnya Tokopedia ialah ingin menciptakan pemerataan ekonomi yang ada di Indonesia. Oleh karena itu, Tokopedia selalu menyesuaikan bisnis yang dapat diterima di seluruh kalangan  masyarakat. Mengingat Indonesia adalah negara yang memiliki masyarakat dari berbagai macam suku, budaya, dan agama. Di mana, agama yang mendominasi masyarakat Indonesia adalah agama Islam. Sebagai agama yang penuh toleransi dalam mengikuti arus perkembangan zaman, Islam tidak akan pernah lekang dalam mengatur akidah, syariat dan akhlak. Begitu pula toleransi agama Islam terhadap perkembangan teknologi dan informasi dalam dunia muamalah seperti e-commerce. Sehingga, tujuan dari penelitian ini untuk mengetahui dan menganalisis strategi promosi Tokopedia serta mengetahui kesesuaiannya dengan syariat Islam. Penelitian ini menggunakan metode kualitatif yang didukung oleh data primer dan data sekunder sebagai pengambilan sumber datanya.
Hak Kepemilikan Dalam Pemanfaatan Air Bersih Di Kawasan Taman Nasional Bukit Tiga Puluh, Provinsi Riau
Authors:   Jurusan Kehutanan, Universitas Riau, Kampus Bina Widya Km. 12,5 Simpang Baru, Pekanbaru, Julianti Vironika , Qomar Nurul ,   Jurusan Kehutanan, Universitas Riau, Kampus Bina Widya Km. 12,5 Simpang Baru, Pekanbaru, Kausar Kausar ,   Jurusan Agribisnis, Universitas Riau, Kampus Bina Widya Km. 12,5 Simpang Baru, Pekanbaru
Published: November 2022

Certainty of property rights will ensure the sustainability of resources, including the use of non-commercial clean water in the Bukit Tiga Puluh National Park (TNBT) area. Data were collected through in-depth interviews,  field  observations,  and  document  studies.  The  results  showed  that  the Sejuk Lestari Drinking Water Supply and Sanitation System Management Group (KPSPAMS) as water manager is a proprietor. The people of Lahai  Kemuning  Village  as  water  users  are  authorized  users. Balai TNBT as the party that manages the area is the owner. The Department of Public Works and Public Housing (PUPR) of Indragiri Hulu Regency as the party that  builds water facilities and infrastructure is an authorized entrance.
Analisis Implementasi Kebijakan Pengelolaan Sampah Di Provinsi Dki Jakarta
Authors:   Pusat Riset Kependudukan, Badan Riset dan Inovasi Nasional, Iqbal Mohamad , Mulyadin R. M. ,   Pusat Standardisasi Instrumen Ketahanan Bencana dan Perubahan Iklim, Jl. Gunung Batu No. 5 Bogor, Jawa Barat, Ariawan Kuncoro ,   Pusat Standardisasi Instrumen Ketahanan Bencana dan Perubahan Iklim, Jl. Gunung Batu No. 5 Bogor, Jawa Barat, Subarudi Subarudi ,   Pusat Riset Kependudukan, Badan Riset dan Inovasi Nasional, Gd. Widya Graha Lt. X, Jl. Jend. Gatot Subroto 10 Jakarta 12710
Published: November 2022

The  waste  problem  can  be  seen  from  the  significant  increase  in  the  volume  of  waste  every  year,  poor  waste  management  and  the  low  public  hygiene  habit  in  big  cities,  including Jakarta. This study aims to analyze the implementation of Jakarta's waste management policies according to Regional Regulation Number 4 of 2019. This study uses a descriptive qualitative approach to obtain comprehensive information about the implementation of existing regional regulations. The results show that the implementation of Jakarta's waste management policies has not been implemented well. There are several obstacles such as a large budget but not used optimally, a lack of coordination between the government and private sector to build Intermediate Treatment Facilities (ITF) because there is a regional politic factor. Several programs such as a waste bank, 3R (reduce, reuse, recycle), and “Sampah Tanggung Jawab Bersama (Samtawa) are expected to be able to overcome the waste problem in Jakarta. These  programs  need  to  be  delivered  through  socialization  to urban villages,  schools,  and  PKK  (Program  Keluarga  Sejahtera).
Pemulihan Ekonomi Yang Lebih Baik Dan Aksi Iklim Papua Barat
Authors:   School of Environmental Science, University of Indonesia, Jl. Salemba Raya No. 4, Jakarta 10430, Indonesia, Karuniasa Mahawan , Maharani Cynthia ,   World Resources Institute (WRI) Indonesia, Jl. Wijaya I No. 63, Jakarta Selatan, 12170, Indonesia
Published: November 2022

Subnational level NDC target formulation is essential for achieving NDC and should be aligned with Built  Back Better Agenda to maintain economic growth post COVID-19. This study aims to formulate NDC target to be implemented in Built Back Better Agenda for the West Papua Province context. It employs system dyna ics methods  based on the systems thinking paradigm, non linear dynamics, and feedback control theory, and focused on systems’  structure  and  behavior.  Results  show  that  the  sustainable  development  scenario  is  better  than  the  conservation  scenario with a total target emission reduction of NDC by 2030 is 64% or 24,91 megatons of CO2e and improves HDI and GRDP.
What Motivates Companies to Take the Decision to Decarbonise?
Authors: Buettner Stefan M. , König Werner , Vierhub-Lorenz Frederick , Gilles Marina
Published: November 2022

Already more than 140 countries consider or have pledged to reach net-zero emission targets by 2050 or earlier and the share of global emissions falling into an emission pricing scheme has steeply increased over the past three years. Even where there are no direct implications for industry (yet), there is a series of subtle pressure points driving an increasing number of companies across the globe to work towards climate neutrality and pledging ambitious emission reduction goals. This article sheds light on the pressure points, the subtle triggers, the underlying considerations as well as the hoped-for benefits for industrial companies from achieving net-zero emissions. The observations and ideas presented in this paper are derived from quantitative data obtained via the Energy Efficiency Index of German Industry (EEI) and qualitative data. Not only societal, work force, supply chain and investor expectations play a large role, but also many strategic considerations which have the potential to make the company more resilient and profitable, particularly in time of crisis. Those companies that do not move towards decarbonisation, on the other hand, may face a costly late-mover disadvantage. This piece uncovers subtle interconnections, helping stakeholders from industry and beyond to grasp opportunities and challenges ahead.
The “Slotstreams” Phenomenon on Twitch.Tv: Can it Lead to Online Gambling?
Authors: Casu Mirko , Belfiore Cecilia Ilaria
Published: November 2022

(1) Background: Twitch.tv is a live video content website. As of 2022, Twitch users are generally adolescents and young adults, with estimates of the percentage of users aged 16-24 between 22.3% and 41%, predominantly males with estimates ranging from 65% to 78.36%. In recent years, “slotstream” content has become increasingly popular, where streamers gamble online while users watch them. (2) Methods: from July 2022 to November 2022, we researched articles related to Twitch, live streaming, gambling, casino, slot, gambling online, modeling, social media influencers, conditioning, and celebrities, searching for relevant studies in the databases LexisNexis Academic, Business Source Complete, PubMed, Web of Science, Freedom Collection, Health & Medical Collection, Elsevier Journal, Springer, APA PsycARTICLES, Wiley, and other single journals. (3) Results: we took into consideration Gambling Disorder, Online Gambling Disorder, and Internet Gaming Disorder on the one hand, and consumer components such as persuasive communication and influencer-audience relationship on the other; we then hypothesized that the presence of these variables within the slotstream format is positively correlated with the development of pathological gambling, especially in an adolescent audience. (4) Conclusion: we assume that there is a positive correlation between watching slotstream content and the probability of developing both pathological and non-pathological gambling behavior.
Laboratory and Metabolomic Fingerprint in Heart Failure With Preserved Ejection Fraction: From Clinical Classification to Biomarker Signature
Authors: Palazzuoli Alberto , Tramonte Francesco , Beltrami Matteo
Published: November 2022

Heart failure with preserved ejection fraction (HFpEF) remains a poorly characterized syndrome with many dark aspects related to different patients profile, various associated risk factors and wide aetiologies. It comprises several pathophysiological pathways related to endothelial dysfunction, myocardial fibrosis, extracellular matrix deposition and high inflammatory response. Up to now, it has been described only for clinical appearance and most common associated risk factors without an effective characterization of biological processes responsible for cardiovascular deteriorations. Recent advances in laboratory and metabolomic researches showed that HFpEF appears strictly related to specific cells and molecular mechanisms dysregulation. Some biomarkers are capable to early identify these processes adding new insights into diagnosis and risk stratification. Additionally recent advances on intermediate metabolites reflecting provide relevant information on intrinsic cellular and energetic substrate alterations. The systematic combination of clinical imaging and laboratory data may lead to a precision medicine approach providing prognostic and therapeutic advantages. Current review reports traditional and emerging biomarkers recently investigated in HFpEF setting, and it purpose a new diagnostic approach based on integrative information achieved from risk factors burden, hemodynamic dysfunction and biomarkers signature partnership.
Artificial Intelligence in the Islamic Finance: A bibliometric Analysis
Authors: Tayachi Tahar , Brahimi Tayeb , Essafi Yasmine , Ben Abdallah Rabeb
Published: November 2022

The paper demonstrates the future of artificial intelligence in the Islamic Banks of Saudi Arabia which introduces with the meaning of artificial intelligence and the benefits which AI may bring with itself in the future. Further, how banks differ in their use of AI from the banks that do not use AI or use original intelligence (Artificial Neural Network) and the acknowledgement of 4 purely Islamic banks in KSA. The literature has analyzed the pros of AI in the Islamic banks taking into consideration machine learning, natural language processing, text mining through neural network of deep learning, algorithmic trading and robotics. It has further analyzed AI’s limitations with regards to its costs, technological unemployment, lack of human creativity and its accountability and regulation. Lastly, the literature has stated AI from the sharia’a point of view. In order to test hypothesis concerning future studies, it was important to collect data using purely Islamic banks. Upon various interpretations concerning AI’s accountability and its impact on sharia’a board, robot’s impact in the long run, AI’s ethics and its uses which people have already encountered and the time period for which AI may imitate human learning in the future- we find that generation Z and millennials are very influenced by AI and have positive views about its scope in the future. However, it is important to note that research limitations include no access to banking authorities due to the recovery after the pandemic of COVID-19 besides.
Effect of Model Structure and Calibration Algorithm on Discharge Simulation
Authors: Alp Harun , Demirel Mehmet Cüneyd , Aşıkoğlu Ömer Levend
Published: November 2022

In this study, Acısu Basin, which is upper side of one of the most important basins (Gediz) in Türkiye, was modelled using three types of hydrological models and three different calibration algorithms. Lumped (GR4J), semi-distributed (SWAT+), and fully distributed (mHM) hydrological models were built and integrated with Parameter Estimation Tool (PEST) which is a model independent calibration tool including various algorithms. Levenberg Marquardt (L-M), Shuffled Complex Evolution (SCE), and Covariance Matrix Adoption Evolution Strategy (CMA-ES) were selected as calibration algorithms. Calibration period was 1991-2000, and validation results were obtained for 2002-2005. The effect of model structure and calibration algorithm selection on discharge simulation was evaluated via comparison of 9 different model-algorithm combinations. Results have shown that mHM and CMA-ES combination showed the best discharge simulation performance according to NSE values (calibration: 0.67, validation: 0.60). Although statistically the model results were classified as acceptable, the pattern comparison of discharge value shows that all of the models miss the peak values in significant amounts. This problem may be related to the interventions made in 2000-2001 years interval and possible to overcome by changing the calibration and validation periods, increasing the number of iterations or using the naturalized gauge data.
Cooperation Among Public Health Nurses in Municipalities and at Public Health Centers for Infection Control at Evacuation Shelters
Authors: Kurita Junko , Yamaguchi Shinobu ,   Department of Nursing, Faculty of Sports and Health Science, Daito Bunka University 560 Iwadono, Higashimatsuyama, Saitama 355-8501, Japan,   Department of Nursing, Ibaraki Prefectural University of Health Sciences, Ami-cho, Japan
Published: November 2022

Infection control is a task of public health centers during normal periods. However, the Japanese Disaster Countermeasures Basic Act requires municipalities to plan and prepare for disasters, including provisions for community health. This study was conducted to assess the cooperation among public health nurses associated with municipalities and public health nurses at public health centers on preparations for infection control at evacuation shelters. After choosing 548 of 1644 municipalities randomly, excluding municipalities that have public health centers, we sent questionnaires to the general directors of public health nurses associated with the municipalities and received responses from 199 municipalities. The questionnaire items assessed 1) cooperation with public health centers during normal periods and 2) disaster manual preparations. We classified municipalities as cooperative based on their responses to the first category of questions, and as prepared based on their responses to the second category. Cooperation with public health centers for infection control at evacuation shelters markedly increased the probability of planning manuals for infection control being prepared at evacuation shelters. The results suggest the importance of public health centers’ aggressive involvement in municipality preparations for infection control at evacuation shelters after a disaster.
Impact of Instrumental Support from Family on Medication Adherence among Tuberculosis Patients: A Cross-Sectional Study
Authors: Nursasi Astuti Yuni , Huda Mega Hasanul , Rahmasari Syifa Widya
Published: November 2022

Instrumental support is concrete and tangible, for instance, helping to provide food or accompanying patients to health care facilities. However, its impact on medication adherence among tuberculosis patients in Indonesia needs to be explored. This study aimed to examine the impact of instrumental support from family on tuberculosis patients’ adherence to medication in Bogor City, West Java Province, Indonesia. A cross-sectional study involving 106 participants with an age average of 39.7 (SD = 14.9) was conducted in 12 primary health care (PHC). The independent variables (age, sex, education, employment status, wealth index, and the distance between home and PHC) of instrumental support from family was assessed using MMAS-8. In contrast, the dependent variable of medication adherence was assessed using a self-reported instrument. Multivariate binary logistic regression was used in the analysis and indicated that participants receiving family support were more likely to adhere to medication protocol (95% CI = 1.1–6.3; p-value = 0.029). Instrumental support from family was associated with medication adherence among tuberculosis patients in Bogor City, West Java Province, Indonesia. It is necessary to design further comprehensive interventions in the community setting to encourage the family to support tuberculosis patients following medication protocol.
Factors Influencing Handwriting Development among Preschool Children: A Systematic Review
Authors: Achymy Zati Izny , Kadar Masne , Razaob Nor Afifi , Wan Yunus Farahiyah
Published: November 2022

Handwriting development is essential for academic performance, yet the research on the factors contributing to it is scant. This systematic review aimed to provide a comprehensive overview of the factors contributing to handwriting development among preschool children that may benefit public health knowledge, especially among teachers, parents, and therapists. A systematic search was conducted using four databases: PubMed, ERIC, CINAHL, and Google Scholar. During the preliminary search, 565 relevant studies were found. Screening, review selection, and characterization were performed based on the inclusion and exclusion criteria. The inclusion criteria included preschool children, quantitative, written in English, and published in January 2012 – January 2022. The exclusion criteria were studies involving children with specific diagnoses. A consensus agreement was obtained, and ten studies were eventually selected for the comprehensive review. Executive function, letter knowledge, motor skills, and writing surface were identified. These factors indicated that handwriting was not an independent process, as its acquisition involved numerous components. This systematic review confirmed that executive function, letter knowledge, motor skills, and writing surface influenced handwriting development. More randomized controlled trials should be conducted to provide more conclusive and exhaustive evidence.
Quality of Life of Hypertensive Patients Undergoing Chronic Disease Management Program during the COVID-19 Pandemic
Authors: Lolo Widya Astuty , Citraningtyas Gayatri , Mpila Deby Afriani , Wijaya Heri , Poddar Sandeep
Published: November 2022

The COVID-19 pandemic has restricted some common activities for hypertensive patients undergoing the Chronic Disease Management Program/Program Pengelolaan Penyakit Kronis in primary health care, decreasing the quality of life. This study aimed to measure the quality of life of hypertensive patients undergoing the Chronic Disease Management Program at primary health care of Manado City, North Sulawesi Province, Indonesia, during the COVID-19 pandemic and determine the factors influencing hypertension such as sex, age, education, employment status, monthly income and duration of hypertension. This cross-sectional study was carried out on 150 hypertensive patients randomly sampled at primary health care from June to September 2021. The data were analyzed using the Mann-Whitney test. The quality of life of non-complicated hypertensive patients was higher than those with complications. The utility value and the visual analog scale of hypertensive patients with and without complications were 0.808±0.13 and 80.2±8.16 and 0.761±0.17 and 75.1±7.56, respectively. The results showed that most hypertensive patients, with or without complications, had a good quality of life.
Factors Associated with Depression among Type 2 Diabetes Mellitus Patients at a Tertiary Hospital during the COVID-19 Pandemic
Authors: Mokoagow Muhammad Ikhsan , Pitawati Dian , Arisandy Ditya Nona , Magfira Nadya , Palupi Pratiwi Indah , Nasarudin Jerry , Epriliawati Marina , Kshanti Ida Ayu
Published: November 2022

Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia that can cause various complications, economic burdens, and psychosocial issues that eventually lead to depression. This study aimed to describe the prevalence of depression among type 2 diabetes mellitus patients in the Internal Medicine Outpatient Clinic of a South Jakarta tertiary hospital during the COVID-19 pandemic. This cross-sectional study was conducted from May to July 2021. The data were collected consecutively from 100 patients aged 18 years or older who came for regular consultation. The instrument used for determining depression is Beck Depression Inventory-II. The prevalence of depression, a correlation between depression and participants' characteristics, and multivariate analysis for risk factors were determined. The results showed that the prevalence of mild to severe depression based on the BDI-II classification was 17%. Screening showed mild to severe depression predominantly in females above 60 years old, with higher levels of education, obesity grade I, individuals with one or more comorbidities, and those who had diabetes for more than ten years. In this study, having one or more comorbidities was associated with an increased risk of depression in people with diabetes.
Ampliación de la producción de lotes de ropa deportiva para su abastecimiento en el mercado de Gamarra de la empresa BRISTHSOL SAC, La Victoria, Lima, Perú, 2021
Authors:   , Jurado Bautista Nadia Naomi , Medrano Fabian Jennifer Estefany , Ortiz Soto Pedro Junior , Taboada Tambine Darly Xiomara
Published: November 2022

El presente trabajo de investigación tiene como finalidad de contestar las dudas de dicha investigación en donde ayudemos a la empresa Brithsol en su ampliación de producción de lotes en ropa deportiva, para su abastecimiento en el mercado de Gamarra, además indicar que la empresa tiene muchos clientes en donde busca la manera de satisfacer sus necesidades. Es por ello que se plantearon objetivos como en ubicarse en un local estratégico, equipando con garantías y certificaciones ofreciendo fiabilidad, también ampliando la cartera de clientes potenciales para incrementar la participación reducida en el mercado ya su vez impulsar la logística para así poder ahorrar costos y relacionados desde el local estratégico. A partir de ello se ha planteado una mejora en sus actividades para la Empresa Brithsol
Factores antecedentes y tipos de lesiones oculares ocurridas en la práctica odontológica: revisión sistemática
Authors:   , Abanto Sheron Jordi
Published: November 2022

Objetivo: El odontólogo y personal auxiliar están en constante riesgo de enfermedades ocupacionales como: alergias, infecciones, lesiones cutáneas u oculares; que podrían afectar a los pacientes. Una problemática de interés social, son las lesiones oculares que ocurren al personal odontológico. La literatura revela la prevalencia de lesiones oculares en la práctica odontológica están asociadas a partículas sólidas; salpicaduras de fluidos. Mediante una revisión sistemática, se revisaron los tipos de lesiones oculares y sus factores asociados ocurridos en la práctica odontológica. Materiales y métodos: Los estudios relevantes se buscaron en las bases de datos: Pubmed, Scopus, Ebsco, entre otros. La búsqueda incluyó estudios transversales que evaluaban la evidencia sobre lesiones oculares ocurridas en la práctica odontológica, excluyendo revisiones de literatura, cartas al lector y editoriales. Resultados: Se incluyeron 8 estudios para desarrollar la revisión sistemática; determinando que los factores asociados de las lesiones oculares ocurridas en la práctica odontológica son: a) uso ocasional de protección ocular b) edad c) sexo d) años de práctica y los tipos de lesiones oculares son la entrada de líquidos y cuerpos extraños. Conclusión: La deficiencia en el cumplimiento de protocolos de protección ocular o facial en la práctica dental, originan las lesiones oculares; de tipo entrada de líquidos, cuerpos extraños, salpicadura de fluidos biológicos o conjuntivitis. Estas lesiones oculares se generan a partir de factores asociados como el uso ocasional de protección ocular, la edad, el sexo y otros.
Improving Accuracy of Code Smells Detection with Data Balancing Techniques
Authors: Khleel Nasraldeen Alnor Adam
Published: November 2022

Code smells are indicators of potential symptoms or problems in software due to inefficient design or incomplete implementation. These problems can affect software quality in the long term. Code smell detection is fundamental to improving software quality and maintainability, reducing the risk of software failure, and helping to refactor the code. Data imbalance is the main challenge of machine learning (ML) techniques in detecting the code smells. Several prediction methods have been applied for code smells detection in our previous works. However, many of them show that, ML methods is not always suitable for code smells detection due to the problem of highly unbalanced data. To overcome these challenges, the objective of this study is to present a code smells detection method based on ML models with data balancing techniques to mitigate data unbalancing issues by taking a corpus of Java projects as experimental datasets. In our experiments, we have used Bidirectional Long Short-Term Memory (Bi-LSTM) and Gated Recurrent Unit (GRU). The performance of these models has been evaluated based on accuracy, precision, recall, f-measure, ROC curve. The results indicate that the use of data balancing techniques had a positive effect on the predictive accuracy of the models presented.
TBX1 functions as a tumor suppressor in colorectal cancer by PPP2R2B-mediated the inhibition of MAPK/ERK and PI3K/AKT signaling pathways
Authors: Zhao Man , Zhao Ya , Xie Jing Yi , Chen Pu , Zeng Ze Kun , Zhang Wen Fang , Dang Hui , Liu Juan , Hou Peng , Meng Du
Published: November 2022

Background:TBX1 is member of T-box family which is characterized by a 180–200 amino acid conserved DNA binding domain, and encodes important developmentally transcription factor. Deregulated TBX1 expression has been implicated in parathyroid tumors and inhibited tumorigenesis. However, its role in colorectal cancer has not been elucidated.Methods:In vitrofunctional studies were performed to assess the TBX1 of the proliferation and colony formation of colorectal cancer cells. Meanwhile, subcutaneous xenograft mouse model was established to determine the effect of TBX1 on tumor growthin vivo. The underlying mechanism of TBX1 in colorectal cancer cells was clarified by a series of molecular and biochemical experiments.Results:Our results showed that TBX1 was significantly down-regulated in colorectal cancers compared with control subjects, and demonstrated that ectopic expression of TBX1 in colorectal cancer cells strongly suppressed cell proliferation, colony-forming ability, cell migration, cell invasion and tumor growth in nude mice by the inhibition of MAPK/ERK and PI3K/AKT signaling pathways. Further studies revealed that TBX1 suppressed these two pathways by directly transcriptionally upregulating protein phosphatase 2 regulatory subunit B (PPP2R2B), thereby playing its tumor suppressor functions. As expected, PPP2R2B knockdown obviously attenuated the inhibitory effect of TBX1 on cell proliferation and colony formation as well as the activities of MAPK/ERK and PI3K/AKT pathways.Conclusion:The present study demonstrates that TBX1 acts as a putative tumor suppressor in colorectal cancer cells by inhibiting PPP2R2B-mediated MAPK/ERK and PI3K/AKT signaling pathways.
Quantitative Ultrasound Image Assessment of the Optic Nerve Subarachnoid Space during 90-day Head-Down Tilt Bed Rest
Authors: Wang Ningli , Xie Yuan , Fu Yingdi , Shao Yaqi , Qu Lina , Yang Jiangang , Yang Chengjia , Zhou Kun , Li Kai , Xu Zi , Xu Dong , Cao Kai , Tian Ning , Lv Ke , Wang Linjie , Wang Yaping , Li Yinghui
Published: November 2022

More than half of long-duration spaceflight astronauts have experienced ophthalmic abnormalities, collectively termed spaceflight-associated neuro-ocular syndrome (SANS). Microgravity-induced elevation in intracranial pressure(ICP), especially optic nerve cerebral spinal fluid pressure (ON-CSFp) due to headward fluid shifts is the primary hypothesized contributor to SANS. However there is limited non-invasive method to monitor ON-CSFp. The present longitudinal study aims to quantify the area of the optic nerve subarachnoid space(ONSSA) in the axial plane behind the optic disc, that is filled with CSF and expands when ON-CSFp is elevated, during and after head-down tilt (HDT) bed rest (BR) and assess its association with relative anthropometric and systemic parameters.72 eyes of 36 healthy male volunteers were included and underwent 90-day strict 6° HDT BR .The measurements were performed on day 30, 60, and 90 of HDT BR and at six recovery time points extending to 180-day in supine position. Portable B-scan ultrasound was performed binocularly, using a 12 MHz linear array probe. The measurement of the optic nerve sheath and calculation of the ONSSA from 3mm to 5mm posterior to the optic disc were performed with ImageJ 1.51 analysis software by two experienced observers in a masked manner. In comparison to recovery day 180, ONSSA from 3mm to 5mm posterior to the optic disc exhibited significant distention on BR day 30,60 and 90, with a mean change of 0.4mm2 (95% CI:0.12 to 0.7 mm2, P = .002), 0.35 mm2 (95% CI:0.02 to 0.69mm2, P = .001), and 0.4 mm2 (95% CI:0.05 to 0.75 mm2, P = .015), respectively. Univariate linear regression analysis showed increased ONSSA was correlated with increased mean blood pressure (Beta = 0.092; 95%CI, 0.016 to 0.169; P = .019). Terrestrially, ONSSA distension is associated with increased ICP. The results indicated that 90-day HDT BR induced elevated ICP especially ON-CSFp in comparison to supine level.Advanced quantitative portable ultrasound-based assessment of the ONSSA could better our understanding the role of ON-CSFp on SANS.
The catalytic performance of CuFe2O4@CQD nanocomposite in nitroaniline group reduction: High-perform heterogeneous nanocatalyst
Authors: Naghash-Hamed Samin , Arsalani Nasser , Mousavi Seyed Borhan
Published: November 2022

In this study, we fabricated an economical, non-toxic, and convenient magnetic nanocomposite of CuFe2O4 nanoparticles (NPs)/carbon quantum dots (CQDs) of citric acid via the co-precipitation method. Afterward, obtained magnetic nanocomposite was used as a nanocatalyst to reduce the ortho-nitroaniline (o-NA) and para-nitroaniline (p-NA) using a reducer agent of sodium borohydride (NaBH4). To investigate the functional groups, crystallite, structure, morphology, and nanoparticle size of the prepared nanocomposite, FT-IR, XRD, TEM, BET, and SEM were employed. The catalytic performance of the nanocatalyst was experimentally evaluated based on the ultraviolet-visible absorbance to assess the reduction of o-NA and p-NA with a reducing agent of NaBH4. The acquired outcomes illustrated that the prepared heterogeneous catalyst significantly enhanced the reduction of o-NA and p-NA substrates. By analyzing the absorption, the remarkable decrease at λmax = 415 nm for ortho-NA in 27 s with a constant rate (kapp) of 8.39 × 10− 2 s− 1 and a notable decline at λmax = 380 nm for para-NA in 8 s with a constant rate of 5.48 × 10− 1 s− 1 were obtained. The most highlighted result of this work was that the CuFe2O4@CQD nanocomposite fabricated from citric acid performed better than absolute CuFe2O4 NPs, since nanocomposite containing CQDs had a more significant impact than copper ferrite NPs.
A New Dual-Input Deep Anomaly Detection Method for Early Faults Warning of Rolling Bearings
Authors: kang yuxiang , CHEN Guo , WANG Hao , PAN Wenping , WEI Xunkai
Published: November 2022

Aiming at the problem of low fault diagnosis accuracy caused by insufficient fault samples of rolling bearings, a dual-input deep anomaly detection method with zero fault samples is proposed for early fault warning of rolling bearings. First, the main framework of dual-input feature extraction based on convolutional neural network(CNN) is established, and the two outputs of the main frame are subjected to the autoencoder structure, and then the secondary feature extraction is performed. At the same time, the experience pool structure is introduced to improve the feature learning ability of the network. A new objective loss function is also proposed to learn the network parameters.. Then, the vibration acceleration signal is preprocessed by wavelet to obtain multiple signals in different frequency bands, and the two signals in the high frequency band are two-dimensionally encoded and used as the input of the network respectively. Finally, the unsupervised learning of the model is completed on 5 sets of actual full-life rolling bearing fault data sets only relying on some samples in normal state. The verification results show that the proposed method can realize earlier than the RMS, Kurtosis and other features. The early fault warning and the accuracy rate of more than 98% fully show that the method has high early fault warning and nomaly detection capabilities.
Anxiety and Depression Symptomology in Adult Siblings of Individuals with Autism
Authors: Arnold Matthew
Published: November 2022

Research into the effects that a child with Autism Spectrum Disorder (ASD) has on the family unit, specifically parents, abounded over the last several decades. The present study sought to evaluate the prevalence, sibship, age and biological sex effects on reported anxiety and depressive symptoms within a sample of adult siblings of an individual with ASD. Population. All participants (N = 500) were from the United States and were mostly Caucasian (93.2%) and even between biological male and female (51.2% female, 48% male), with an average age of 33 years old. Method. This exploratory study used an online survey, where respondents provided demographics and responded to a series of questions regarding their sibship. Respondents then took the Generalized Anxiety Disorder 7-Item Scale (GAD-7) and the Center for Epidemiological Studies Depression Scale (CES-D). Their total GAD-7 scores and CES-D scores were analyzed with their age, sibship (older/younger/same), age distance from their sibling with ASD and biological sex. Results. 64.2% of adult siblings of individuals with ASD reported clinically significant anxious scores and 85% reported clinicallydepression. Among adult siblings, older siblings were more likely to experience both depressive and anxious symptoms. Siblings 8-13 years younger and >25 years older than their siblings with ASD were at the highest risk of experiencing these symptoms to a more extreme degree than other age distance siblings. Lastly, there was higher rates of depression in female siblings, but no sex differences for anxiety. Discussion. Limitations to this study are explored. Further research is needed to examine whether these findings were mitigated by sample size, demographic representation, study question limits, geography and more. The findings highlight the support needs of all members of the family of individuals with ASD.
The Effects of Sesame Oil on Glycemic Control, Inflammation, and Oxidative Stress in Women with Non-alcoholic Fatty Liver Disease in the Context of a Weight Loss Program: A Parallel, Double-Blind, Randomized Clinical Controlled Trial
Authors: Atefi Masoumeh , Entezari Mohammad Hassan Hassan , Vahedi Hamid
Published: November 2022

Background/objective

Some dietary components such as phytochemicals, antioxidants, and monounsaturated acids (MUFAs) are related to the risk reduction of non-alcoholic fatty liver disease (NAFLD). These components exist in sesame oil (SO). This study aimed to assess the effects of SO consumption on glycemic control, inflammation, and oxidative stress undergoing a weight loss diet in women with NAFLD.

Methods

60 women with NAFLD (aged 20–50 years) participated in this randomized, double-blind, parallel, controlled trial. In this study, the routine oil was replaced with SO for 12 weeks. All the subjects received a hypocaloric diet (-500 kcal/day) during the intervention. Serum fasting blood glucose (FBG), fasting serum insulin (FSI), homeostatic model assessment for insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), serum high-sensitivity C-reactive protein (hs-CRP), and serum malondialdehyde (MDA) were measured at pre- and post-intervention phases.

Results

53 subjects completed the intervention. Significant reductions in body mass index (BMI) and body weight (BW) were observed in both groups. After adjusting for confounders, SO resulted in significant improvements in FBG, FSI, HOMA-IR and QUICKI compared to the control group (p < 0.05). However, the reduction in hs-CRP and MDA were not significant (p > 0.05).

Conclusions

SO was shown to beneficially affect the glycemic control markers (including FBG, FSI, HOMA-IR, and QUICKI) in patients with NAFLD.
Cross-county Carbon Governance in Zhejiang Province, China under Rescaling and Institutional Embedding
Authors: Zhou Congyue , Wang Zhu , Guo Rui , Sun Yuan
Published: November 2022

Driven by China's dual carbon target and considering the heterogeneity and fragmentation of county-level cities, this study explored cross-county collaborative carbon reduction through regional rescaling and institutional embedding. Taking Zhejiang Province, China, as an example, a cross-county collaborative governance model was established using a gravity model and social network analysis to establish a new carbon governance boundary and a carbon locus of authority and responsibility. The results show that: (1) Counties with higher carbon linkages have linear characteristics, while lower counties have network structures. (2) The direction of county cooperation is central-oriented and geo-oriented. (3) The radiation region of low-carbon counties presents multi-polarization features, including three main growth poles and four secondary growth poles. According to the above, this study breaks through the existing barriers of prefecture-level administrative regionalization to reorganize counties with high interaction intensity of carbon factors. Eventually, the regions of Zhejiang Province were reconstructed into 12 cross-county carbon governance alliances.
Serum cholinesterase: a cost-effective prognostic predictor in urothelial carcinoma of the bladder
Authors: Li Qiguang , Wei Wei , Tang Xinong , Bi Gewen , Hu Gaohua , Chen Qiwei , Long Xian , Chen Rongchao , Li Yongpeng , Qin Zhibiao , Yi Xianlin
Published: November 2022

Background: Serum cholinesterase (CHE) has been reported to affect the prognosis of several cancers. In this study, we examined the relationship between serum CHE levels and clinical aspects of urothelial carcinoma of the bladder (UCB).
Methods: We retrospectively analyzed clinical data collected from 279 patients diagnosed with UCB at our hospital from 2010 to 2016. Using regression, we examined the relationship of serum CHElevels at different pre- and postoperative time points with prognosis. Follow-up was conducted from the date of surgery to December 31, 2019.
Results: Preoperative serum CHE was associated with tumor size, pathological grade, squamous differentiation, invasion, muscle-invasion, lymph node metastasis, distant metastasis, and recurrence of UCB. Logistic regression identified low preoperative serum CHE levels as an independent risk factor of higher pathological grade and invasion. Postoperative serum CHE levels decreased significantly faster among UCB patients who had undergone radical cystectomy than those who had undergone non-radical cystectomy, then increase to the original basic level, suggesting feedback mechanisms in patients with UCB that restored baseline CHE levels. Low levels of preoperative serum CHE were associated with poor progression-free survival and overall survival. Cox regression showed that low levels of preoperative serum CHE are an independent predictive factor for poor prognosis in patients with muscle-invasive urothelial carcinoma of the bladder without distant metastasis. Receiver operating characteristic curves showed that low preoperative serum CHE levels can be a moderately reliable predictor of recurrence and death among patients with muscle-invasive UCB.
Conclusion: Preoperative serum CHE levels in patients with UCB negatively correlate with pathological grade and invasion. Low preoperative serum CHE levels can predict poor prognosis in patients with muscle-invasive UCB without metastasis. Further research much be conducted to gain a better understanding of the mechanisms through which serum CHE levels affect UCB progression.
Confidence of undergraduate students and new graduates in performing tooth extractions - An exploratory study
Authors: Gaballah Kamis , Ali Kamran , Zahra Daniel , Neel Ensanya , Ibrahim Eteman
Published: November 2022

Aim: To evaluate pre-extraction assessment skills of dental students and interns and explore their self-perceived confidence in performing these tooth extractions.
Methods: A cross-sectional survey investigated the self-perceived confidence to perform the extraction for a set of eight expert-rated cases. The participants were dental students in years 4, and 5 of the Bachelor of Dental Surgery (BDS) program and interns. The participants were asked to rate the difficulty level of each of the eight tooth extraction cases. The self-perceived confidence of the participants to perform extraction of each was also explored. Finally, the participants were asked to identify the main reason for the perceived lack of confidence.
Results: A total of 199 responded to the survey, yielding al response rate of 94.7%. The effect of Grade of Extraction (the expert rating of cases), and Stage on difficulty ratings was assessed using a mixed 3 Stage x 4 Grades ANOVA, with response (Difficult=1, Easy=0) as the dependent variable. The results showed that there was a main effect of Stage, a main effect of Grade of extraction and a significant interaction between the two. Gender showed a significant impact with females categorizing significantly more cases as difficult. A three-way contingency table (counts of each confidence-level response by Stage by Expert rating of cases) suggests a statistically significant association between the three factors. Most participants identified limited clinical exposure as the main reason for their perceived lack of confidence.
Conclusions: The findings of this study show that a majority of the participants were able to recognize tooth extraction cases which were beyond the scope of their training stage with females reporting lower a confidence. Increased clinical exposure to a wider range of tooth extraction cases with varying levels of difficulty may contribute to improving the self-confidence of undergraduate dental students and interns.
Online Tool Wear Monitoring Based on Multi-sensor Feature Fusion and Domain Adaptation
Authors: Liu Dahu , Wang Yongchao , He Huan
Published: November 2022

Machine tool condition monitoring is of great significance for machine tool health management and machining quality. There exist a series of problems in the existing models, such as a large error in the prediction of machine tool wear, and the possible differences in the distribution of the training set and testing set are not considered. In this work, the residual connection block and channel attention block are sequentially stacked as the feature extractor. The introduction of domain adaptation enables the model to extract domain-independent features. Through the weight discrepancy restriction, the feature vectors between different sensors are driven to be orthogonal to improve the effectiveness and comprehensiveness of feature extraction. Finally, the fusion features are mapped to the tool wear value through the fully connected layer. To verify the model effect, experiments were conducted using the PHM 2010 milling cutter wear dataset. The experiment results indicate that the average RMSE and average MAE of this model are 6.97 and 6.29 on the three tools C1, C4, and C6, respectively. There is more than a 12% improvement compared with TCN, TDConvLSTM, and other models.
Assessment on the Causes of Improper Waste Segregation Among Second Year Degree Nursing Students at a University, Windhoek, Khomas Region
Authors: Kadhila Galukeni Joseph , Andima Zeneyd
Published: November 2022

Background: Africa is facing a growing management crisis while the volume of waste is relatively small compared to the developed region, the mismanagement of waste in Africa is currently impacting human and environmental health. Therefore, this paper was conducted to assess the causes that contribute to improper waste segregation.
Research methodology: A quantitative, descriptive study was used in this study. Simple random sampling was used in this study by selecting the second-year students. The frequency distribution of tables and graphs have been used in this study for data analysis.
Results: The results have revealed that, n=20 (50%) strongly disagrees=18 (45%) strongly agreed, n=2 (5%) disagreed, that there are no signals /posters about color coding in the wards
Conclusion: The finding from this study indicates a lack of knowledge on how to discard waste properly among second-year degree nursing students as a contributing factor to non-adherence to proper waste segregation. The findings also indicated that there were no policies on color coding and unawareness of soiled waste that contributes to improper waste segregation.