bluuebunny/crossref_metadata_2025 huggingface dataset:
Box–Behnken Design-Based Optimization of Phytochemical Extraction from Diplazium esculentum (Retz.) Sw. Associated with Its Antioxidant and Anti-Alzheimer’s Properties
Authors: Kongsung Sirawit , Inthachat Woorawee , Chantong Boonrat , Suttisansanee Uthaiwan , On-Nom Nattira , Chupeerach Chaowanee , Thangsiri Sirinapa , Pitchakarn Pornsiri , Temviriyanukul Piya
Published: May 2024

A previous study reported that the ethanolic extract of the edible fern, Diplazium esculentum (Retz.) Sw. (DE), obtained from a non-optimized extraction condition exhibited anti-Alzheimer’s disease (AD) properties through the inhibition of a rate-limiting enzyme in amyloid peptide formation, β-secretase-1 (BACE-1). Nevertheless, a non-optimized or suboptimal extraction may lead to several issues, such as a reduction in extraction efficiency and increased time and plant materials. In this study, extraction of the DE was optimized to obtain appropriate BACE-1 inhibition using a Box–Behnken design (BBD) and response surface methodology (RSM). Data revealed that the optimal extraction condition was 70% (v/v) aqueous ethanol, 50 min extraction time, 30 °C extraction temperature, and 1:30 g/mL solid/liquid ratio, giving BACE-1 inhibition at 56.33%. In addition, the extract also exhibited significant antioxidant activities compared to the non-optimized extraction. Metabolomic phytochemical profiles and targeted phytochemical analyses showed that kaempferol, quercetin, and their derivatives as well as rosmarinic acid were abundant in the extract. The optimized DE extract also acted synergistically with donepezil, an AD drug suppressing BACE-1 activities. Data received from Drosophila-expressing human amyloid precursor proteins (APPs) and BACE-1, representing the amyloid hypothesis, showed that the optimized DE extract penetrated the fly brains, suppressed BACE-1 activities, and improved locomotor functions. The extract quenched the expression of glutathione S transferase D1 (GSTD1), inositol-requiring enzyme (IRE-1), and molecular chaperone-binding immunoglobulin (Bip), while donepezil suppressed these genes and other genes involved in antioxidant and endoplasmic reticulum (ER) stress response, including superoxide dismutase type 1 (SOD1), activating transcription factor 6 (ATF-6), and protein kinase R-like endoplasmic reticulum kinase (PERK). To sum up, the optimized extraction condition reduced extraction time while resulting in higher phytochemicals, antioxidants, and BACE-1 inhibitors.
A Review for Uncovering the “Protein-Nanoparticle Alliance”: Implications of the Protein Corona for Biomedical Applications
Authors: Önal Acet Burcu , Gül Désirée , Stauber Roland H. , Odabaşı Mehmet , Acet Ömür
Published: May 2024

Understanding both the physicochemical and biological interactions of nanoparticles is mandatory for the biomedical application of nanomaterials. By binding proteins, nanoparticles acquire new surface identities in biological fluids, the protein corona. Various studies have revealed the dynamic structure and nano–bio interactions of the protein corona. The binding of proteins not only imparts new surface identities to nanoparticles in biological fluids but also significantly influences their bioactivity, stability, and targeting specificity. Interestingly, recent endeavors have been undertaken to harness the potential of the protein corona instead of evading its presence. Exploitation of this ‘protein–nanoparticle alliance’ has significant potential to change the field of nanomedicine. Here, we present a thorough examination of the latest research on protein corona, encompassing its formation, dynamics, recent developments, and diverse bioapplications. Furthermore, we also aim to explore the interactions at the nano–bio interface, paving the way for innovative strategies to advance the application potential of the protein corona. By addressing challenges and promises in controlling protein corona formation, this review provides insights into the evolving landscape of the ‘protein–nanoparticle alliance’ and highlights emerging.
The Beneficial Effects of Nordic Walking Training Combined with Time-Restricted Eating 14/24 in Women with Abnormal Body Composition Depend on the Application Period
Authors: Czerwińska-Ledwig Olga , Kryst Joanna , Ziemann Ewa , Borkowska Andżelika , Reczkowicz Joanna , Dzidek Adrianna , Rydzik Łukasz , Pałka Tomasz , Żychowska Małgorzata , Kupczak Wojciech , Blaščáková Marta Mydlárová , Piotrowska Anna
Published: May 2024

The aim of the study was to assess the impact of two lengths of Nordic walking (NW) training interventions combined with time-restricted eating (TRE) on improving body-composition parameters, lipid profiles, and levels of selected adipokines in women with elevated body mass. Overweight and obese women (n = 55, age: 21–85) were recruited. Four groups were selected: 6 weeks (SG6, n = 13) and 12 weeks intervention (SG12, n = 13); and two control groups: CON6 (n = 13) and CON12 (n = 13). The training sessions took place three times a week (60 min each) and were conducted outdoors under the supervision of a professional coach. The training intensity was determined individually. The extended NW program combined with TRE induced a significant weight reduction in SG12 by 1.96 kg (p = 0.010) and fat tissue by 1.64 kg (p = 0.05). The proposed interventions did not affect LBM, TBW [kg], VFA, and lipid profile. The LDL/HDL ratio changed with a small size effect. The leptin concentration differed between groups (p = 0.006), but not over time. For resistin, the differentiating factor was time (p = 0.019), with lower results observed after the intervention. The change in leptin concentration was negatively correlated with its baseline concentration (p = 0.025). Extended to 12 weeks, this intervention allows for an improvement in body composition. Neither 6 nor 12 weeks of training and fasting affected the lipoprotein profile. It is, therefore, indicated to recommend prolonged training protocols and to inform patients that beneficial effects will be seen only after prolonged use of training and time-restricted eating.
How Dietary Choices and Nutritional Knowledge Relate to Eating Disorders and Body Esteem of Medical Students? A Single-Center Cross-Sectional Study
Authors: Kosendiak Aureliusz Andrzej , Adamczak Bartosz Bogusz , Kuźnik Zofia , Makles Szymon
Published: May 2024

Eating disorders and body image concerns are increasingly prevalent issues among young individuals, with medical students being particularly vulnerable due to heightened stress levels. This study enrolled 879 medical students to investigate these concerns. The KomPAN questionnaire was utilized to assess dietary habits and knowledge, the Body Esteem Scale (BES) to evaluate body satisfaction, and The Eating Attitudes Test (EAT-26) to identify eating disorders. A higher level of nutritional knowledge was found to be statistically significantly associated with attempts at excessive calorie restriction among women (β = 0.0864) and negatively among men (β = −0.2039). Moreover, it was negatively associated with self-control of food intake only among men (β = −0.2060). Furthermore, a higher BMI was associated with attempts of excessive calorie restriction in both women and men (β = 0.1052 and β = 0.1656, respectively) and negatively with self-control of food intake (β = −0.0813 and β = −0.1453, respectively). A higher BMI was associated with poorer body esteem across all variables in both genders, except for upper body strength among men. Nutritional knowledge did not correspond with any of these variables, while dietary quality was positively associated with physical condition in women and with physical condition, physical attractiveness, and upper body strength in men. Our study findings suggest that dietary interventions could be improved by considering gender-based behavioral differences and focusing on portion control for individuals with a higher BMI. Caution is warranted in extrapolating the results to the general population due to the specific nature of the study population.
Exploring the Causal Effects of Mineral Metabolism Disorders on Telomere and Mitochondrial DNA: A Bidirectional Two-Sample Mendelian Randomization Analysis
Authors: Feng Zhijun , Wang Yinghui , Fu Zhengzheng , Liao Jing , Liu Hui , Zhou Meijuan
Published: May 2024

The aim of this study was to assess the causal relationships between mineral metabolism disorders, representative of trace elements, and key aging biomarkers: telomere length (TL) and mitochondrial DNA copy number (mtDNA-CN). Utilizing bidirectional Mendelian randomization (MR) analysis in combination with the two-stage least squares (2SLS) method, we explored the causal relationships between mineral metabolism disorders and these aging indicators. Sensitivity analysis can be used to determine the reliability and robustness of the research results. The results confirmed that a positive causal relationship was observed between mineral metabolism disorders and TL (p < 0.05), while the causal relationship with mtDNA-CN was not significant (p > 0.05). Focusing on subgroup analyses of specific minerals, our findings indicated a distinct positive causal relationship between iron metabolism disorders and both TL and mtDNA-CN (p < 0.05). In contrast, disorders in magnesium and phosphorus metabolism did not exhibit significant causal effects on either aging biomarker (p > 0.05). Moreover, reverse MR analysis did not reveal any significant causal effects of TL and mtDNA-CN on mineral metabolism disorders (p > 0.05). The combination of 2SLS with MR analysis further reinforced the positive causal relationship between iron levels and both TL and mtDNA-CN (p < 0.05). Notably, the sensitivity analysis did not indicate significant pleiotropy or heterogeneity within these causal relationships (p > 0.05). These findings highlight the pivotal role of iron metabolism in cellular aging, particularly in regulating TL and sustaining mtDNA-CN, offering new insights into how mineral metabolism disorders influence aging biomarkers. Our research underscores the importance of trace element balance, especially regarding iron intake, in combating the aging process. This provides a potential strategy for slowing aging through the adjustment of trace element intake, laying the groundwork for future research into the relationship between trace elements and healthy aging.
Association of Mycoplasma canis with Fertility Disorders in Dogs: A Case Study Supported by Clinical Examination, PCR, 16S Microbiota Profiling, and Serology
Authors: Suhadolc Scholten Sara , Slavec Brigita , Klinc Primož , Tozon Nataša , Papić Bojan , Koprivec Saša
Published: May 2024

The role of Mycoplasma canis in canine fertility disorders is still poorly understood. As infection is often asymptomatic, there is an increasing need for appropriate diagnostic methods and treatment plans that would allow the reliable detection of M. canis infection and rapid alleviation of infection symptoms in affected dogs. In this study, we included 14 dogs with fertility problems and 16 dogs without fertility disorder signs. We compared clinical examination data and selected laboratory parameters (hematology and biochemistry) between the groups. We performed PCR-based detection of M. canis and 16S rRNA gene-based microbiota profiling of DNA isolated from vaginal and preputial swabs. Dog sera were tested for the presence of M. canis-specific antibodies. Hematological and selected biochemical parameters showed no differences between groups. PCR-based detection of M. canis in the samples was consistent with the results of 16S microbiota profiling. Several other bacterial taxa were also identified that could potentially be involved in different fertility disorders. Serological methods were not accurate enough since high cross-reactivity rates were observed. In the future, more accurate and efficient methods will be needed to determine the role of M. canis and its true role in the pathogenesis of specific fertility disorders in dogs.
Medical Device-Associated Biofilm Infections and Multidrug-Resistant Pathogens
Authors: Bouhrour Nesrine , Nibbering Peter H. , Bendali Farida
Published: May 2024

Medical devices such as venous catheters (VCs) and urinary catheters (UCs) are widely used in the hospital setting. However, the implantation of these devices is often accompanied by complications. About 60 to 70% of nosocomial infections (NIs) are linked to biofilms. The main complication is the ability of microorganisms to adhere to surfaces and form biofilms which protect them and help them to persist in the host. Indeed, by crossing the skin barrier, the insertion of VC inevitably allows skin flora or accidental environmental contaminants to access the underlying tissues and cause fatal complications like bloodstream infections (BSIs). In fact, 80,000 central venous catheters—BSIs (CVC-BSIs)—mainly occur in intensive care units (ICUs) with a death rate of 12 to 25%. Similarly, catheter-associated urinary tract infections (CA-UTIs) are the most commonlyhospital-acquired infections (HAIs) worldwide.These infections represent up to 40% of NIs.In this review, we present a summary of biofilm formation steps. We provide an overview of two main and important infections in clinical settings linked to medical devices, namely the catheter-asociated bloodstream infections (CA-BSIs) and catheter-associated urinary tract infections (CA-UTIs), and highlight also the most multidrug resistant bacteria implicated in these infections. Furthermore, we draw attention toseveral useful prevention strategies, and advanced antimicrobial and antifouling approaches developed to reduce bacterial colonization on catheter surfaces and the incidence of the catheter-related infections.
Using Polymers as Crystal Inhibitors to Prevent the Crystallization of the Rotigotine Patch
Authors: Liu Qiantong , Li Xing , Liu Bo , Kong Jiahao , Wang Qing , Gao Zhigang
Published: May 2024

This study aimed to enhance the stability of the Rotigotine (ROT) patch using polymers as crystal inhibitors. Three polymers (Poloxamer 188, Soluplus, TPGS) were selected as crystal inhibitors to formulate ROT patches with varying drug loadings (20%, 40%, 60%, and 80%, w/w). SEM and XRD analysis revealed that the Soluplus and Soluplus-TPGS groups with a high concentration (80%, w/w) of ROT could be stored at room temperature for at least 90 days without crystallization. Moreover, the crystallization nucleation time and growth rate were utilized to assess the ability of Poloxamer 188, Soluplus, and TPGS to hinder the formation of ROT crystals and slow down its crystallization rate. Molecular docking results elucidated the intermolecular forces between ROT and different polymers, revealing their mechanisms for crystal inhibition. The ROT-Soluplus-TPGS combination exhibited the lowest binding free energy (−5.3 kcal/mol), indicating the highest binding stability, thereby effectively reducing crystal precipitation. In vitro skin permeation studies demonstrated that ROT patches containing crystal inhibitors exhibited promising transdermal effects. With increasing ROT concentration, the cumulative drug permeation substantially increased, while the lag time was notably reduced. This study offers novel insights for the development of ROT patches.
Chitosan-GSNO Nanoparticles and Silicon Priming Enhance the Germination and Seedling Growth of Soybean (Glycine max L.)
Authors: Steven Senabulya , Islam Mohammad Shafiqul , Ghimire Amit , Methela Nusrat Jahan , Kwon Eun-Hae , Yun Byung-Wook , Lee In-Jung , Kim Seong-Hoon , Kim Yoonha
Published: May 2024

Soybean, a major legume crop, has seen a decline in its production owing to challenges in seed germination and the development of seedlings. Thus, in this study, we systematically investigated the influence of various chitosan–S-nitrosoglutathione (chitosan-GSNO) nanoparticle (0, 25, 50, and 100 µM) and Si (0, 0.5, and 1 mM) priming concentrations on soybean seed germination and seedling growth over five different priming durations (range: 1–5 h at each concentration). Significant differences were observed in all parameters, except seedling diameter, with both treatments. Seed germination was significantly enhanced after 3 h of priming in both treatments. The final germination percentage (FGP), peak germination percentage (PGP), vigor index (VI), seedling biomass (SB), hypocotyl length (HL), and radical length (RL) of 100 μM chitosan-GSNO-nanoparticle-primed seeds increased by 20.3%, 41.3%, 78.9%, 25.2%, 15.7%, and 65.9%, respectively, compared with those of the control; however, the mean germination time (MGT) decreased by 18.43%. Si priming at 0.5 mM increased the FGP, PGP, VI, SB, HL, and RL by 13.9%, 55.17%, 39.2%, 6.5%, 22.5%, and 25.1%, respectively, but reduced the MGT by 12.29% compared with the control treatment. Chitosan-GSNO and Si treatment up-regulated the relative expression of gibberellic acid (GA)-related genes (GmGA3ox3 and GmGA2ox1) and down-regulated that of abscisic acid (ABA)-related genes (GmABA2, GmAAO3, and GmNCED5). Chitosan-GSNO and Si application increased bioactive GA4 levels and simultaneously reduced ABA content. Hence, the use of exogenous chitosan-GSNO nanoparticles and Si as priming agents had a beneficial effect on seed germination and seedling growth because of the up-regulation in the expression of GA and down-regulation in the expression of ABA. Additional research is needed to understand the combined impact of Si and chitosan-GSNO nanoparticles, including their effects on the expression levels of other hormones and genes even in the later growth stage of the crop.
Effects of Wind Exposure and Deficit Irrigation on Vegetative Growth, Yield Components and Berry Composition of Malbec and Cabernet Sauvignon
Authors: Alonso Rodrigo , Muñoz Flavio , Bottini Rubén , Piccoli Patricia , Berli Federico J.
Published: May 2024

The impact of global warming on Argentine viticulture may result in a geographical shift, with wine-growing regions potentially moving towards the southwest, known as one of the windiest regions in the world. Deficit irrigation is a widely used strategy to control the shoot growth and improve fruit quality attributes, such as berry skin polyphenols. The present study aimed to assess the effects of different wind intensities and irrigation levels, as well as their interactions, on field-grown Vitis vinifera L. cvs. Malbec and Cabernet Sauvignon. The experiment was conducted during two growing seasons with two wind treatments (sheltered and exposed) and two irrigation treatments (well-watered and moderate deficit irrigation) in a multifactorial design. Vegetative growth, stomatal conductance, shoot biomass partition, fruit yield components and berry skin phenolics were evaluated. Our study found that, generally, wind exposure reduced vegetative growth, and deficit irrigation increased the proportion of smaller berries within the bunches. Meanwhile, deficit irrigation and wind exposure additively increased the concentration of berry skin phenolics. Combined stressful conditions enhance biomass partition across the shoot to fruits in Malbec, increasing the weight of bunches and the number of berries. Our findings offer practical implications for vineyard managers in windy regions, providing actionable insights to optimize grapevine cultivation and enhance wine quality.
Isolation and Characterization of Plant-Growth-Promoting, Drought-Tolerant Rhizobacteria for Improved Maize Productivity
Authors: Agunbiade Victor Funso , Fadiji Ayomide Emmanuel , Agbodjato Nadège Adoukè , Babalola Olubukola Oluranti
Published: May 2024

Drought is one of the main abiotic factors affecting global agricultural productivity. However, the application of bioinocula containing plant-growth-promoting rhizobacteria (PGPR) has been seen as a potential environmentally friendly technology for increasing plants’ resistance to water stress. In this study, rhizobacteria strains were isolated from maize (Zea mays L.) and subjected to drought tolerance tests at varying concentrations using polyethylene glycol (PEG)-8000 and screened for plant-growth-promoting activities. From this study, 11 bacterial isolates were characterized and identified molecularly, which include Bacillus licheniformis A5-1, Aeromonas caviae A1-2, A. veronii C7_8, B. cereus B8-3, P. endophytica A10-11, B. halotolerans A9-10, B. licheniformis B9-5, B. simplex B15-6, Priestia flexa B12-4, Priestia flexa C6-7, and Priestia aryabhattai C1-9. All isolates were positive for indole-3-acetic acid (IAA), siderophore, 1-aminocyclopropane-1-carboxylate (ACC) deaminase, ammonia production, nitrogen fixation, and phosphate solubilization, but negative for hydrogen cyanide production. Aeromonas strains A1-2 and C7_8, showing the highest drought tolerance of 0.71 and 0.77, respectively, were selected for bioinoculation, singularly and combined. An increase in the above- and below-ground biomass of the maize plants at 100, 50, and 25% water-holding capacity (WHC) was recorded. Bacterial inoculants, which showed an increase in the aerial biomass of plants subjected to moderate water deficiency by up to 89%, suggested that they can be suitable candidates to enhance drought tolerance and nutrient acquisition and mitigate the impacts of water stress on plants.
Production and Characterization of Nanocellulose from Maguey (Agave cantala) Fiber
Authors: Sumarago Erwin C. , dela Cerna Mary Frahnchezka M. , Leyson Andrea Kaylie B. , Tan Noel Peter B. , Magsico Kendra Felizimarie
Published: May 2024

Plant fibers have been studied as sources of nanocellulose due to their sustainable features. This study investigated the effects of acid hydrolysis parameters, reaction temperature, and acid concentration on nanocellulose yield from maguey (Agave cantala) fiber. Nanocellulose was produced from the fibers via the removal of non-cellulosic components through alkali treatment and bleaching, followed by strong acid hydrolysis for 45 min using sulfuric acid (H2SO4). The temperature during acid hydrolysis was 30, 40, 50, and 60 °C, and the H2SO4 concentration was 40, 50, and 60 wt. % H2SO4. Results showed that 53.56% of raw maguey fibers were isolated as cellulose, that is, 89.45% was α-cellulose. The highest nanocellulose yield of 81.58 ± 0.36% was achieved from acid hydrolysis at 50 °C using 50 wt. % H2SO4, producing nanocellulose measuring 8–75 nm in diameter and 72–866 nm in length, as confirmed via field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM) analysis. Fourier-transform infrared spectroscopy (FTIR) analysis indicated the chemical transformation of fibers throughout the nanocellulose production process. The zeta potential analysis showed that the nanocellulose had excellent colloidal stability with a highly negative surface charge of −37.3 mV. Meanwhile, X-ray diffraction (XRD) analysis validated the crystallinity of nanocellulose with a crystallinity index of 74.80%. Lastly, thermogravimetric analysis (TGA) demonstrated that the inflection point attributed to the cellulose degradation of the produced nanocellulose is 311.41 °C.
Modelling the Melting Kinetics of Polyetheretherketone Depending on Thermal History: Application to Additive Manufacturing
Authors: Benarbia Adel , Sobotka Vincent , Boyard Nicolas , Roua Christophe
Published: May 2024

Recent techniques for forming thermoplastics, such as welding, automated fibre placement or additive manufacturing, generate successive rapid heating and cooling cycles that cause the partial melting of crystals during the process. The melting of an interface is essential to guarantee a good molecular diffusion across the welded parts. Nevertheless, no model can correctly predict the melting kinetics and consequently the evolution of the crystalline degree during the layers’ deposition process. The purpose of this paper was to define the melting kinetics depending on the crystallization conditions for polyetheretherketone (PEEK). Firstly, a non-isothermal crystallization model was proposed over a wide range of cooling rates from 0.1 K.s−1 to 150 K.s−1. Experimental results have highlighted a dual-mode behaviour of melting and demonstrated the dependence of melting temperatures on crystallization conditions. Based on these observations, a model was developed to predict the melting behaviour after non-isothermal crystallization. The melting model revealed that after high cooling rates, primary and secondary crystals melt separately at low temperatures, while after slow cooling rates, both structures melt simultaneously at higher temperatures. Finally, the melting model was applied to the FFF thermal cycle to illustrate the influence of process parameters on the melting kinetics during deposition.
Green Synthesis of Bioplastics from Microalgae: A State-of-the-Art Review
Authors: Adetunji Adegoke , Erasmus Mariana
Published: May 2024

The synthesis of conventional plastics has increased tremendously in the last decades due to rapid industrialization, population growth, and advancement in the use of modern technologies. However, overuse of these fossil fuel-based plastics has resulted in serious environmental and health hazards by causing pollution, global warming, etc. Therefore, the use of microalgae as a feedstock is a promising, green, and sustainable approach for the production of biobased plastics. Various biopolymers, such as polyhydroxybutyrate, polyurethane, polylactic acid, cellulose-based polymers, starch-based polymers, and protein-based polymers, can be produced from different strains of microalgae under varying culture conditions. Different techniques, including genetic engineering, metabolic engineering, the use of photobioreactors, response surface methodology, and artificial intelligence, are used to alter and improve microalgae stocks for the commercial synthesis of bioplastics at lower costs. In comparison to conventional plastics, these biobased plastics are biodegradable, biocompatible, recyclable, non-toxic, eco-friendly, and sustainable, with robust mechanical and thermoplastic properties. In addition, the bioplastics are suitable for a plethora of applications in the agriculture, construction, healthcare, electrical and electronics, and packaging industries. Thus, this review focuses on techniques for the production of biopolymers and bioplastics from microalgae. In addition, it discusses innovative and efficient strategies for large-scale bioplastic production while also providing insights into the life cycle assessment, end-of-life, and applications of bioplastics. Furthermore, some challenges affecting industrial scale bioplastics production and recommendations for future research are provided.
Snow Disaster Risk Assessment Based on Long-Term Remote Sensing Data: A Case Study of the Qinghai–Tibet Plateau Region in Xizang
Authors: Sun Xiying , Miao Lizhi , Feng Xinkai , Zhan Xixing
Published: May 2024

The risk analysis and assessment of snow disasters are essential foundational tasks in natural disaster management and profoundly impact the scientific and precise formulation of disaster prevention, preparedness, and mitigation strategies. Employing the theory and methodology of snow disaster assessment, this research focuses on historical and potential snow disasters in the Qinghai–Tibetan Plateau (QTP) Region. Utilizing a long-time-series snow depth remote sensing dataset, we extracted six assessment indicators for historical snow disaster risk factors and potential snow disaster risk factors. We determined the weights of these six assessment indicators using the entropy weight method. Subsequently, we established a snow disaster assessment model to evaluate the grade distribution of snow disasters in the study area. This method can effectively solve the problem of the sparse data distribution of meteorological stations and reflect degrees of snow disaster risk on a large spatial scale. The findings reveal that areas with a relatively high snow disaster risk are primarily concentrated in the western part of the Ali Region, the central part of Chamdo, and near the border in Southern Xizang. Additionally, regions with a high frequency of snow disasters are predominantly located at the junction of Nagchu, Chamdo, and Nyingchi in the eastern part of Xizang. These results contribute valuable insights into the risk assessment of snow disasters and facilitate the development of effective strategies for disaster management in the region.
Waterlogged Area Identification Models Based on Object-Oriented Image Analysis and Deep Learning Methods in Sloping Croplands of Northeast China
Authors: Xie Peng , Wang Shihang , Wang Meiyan , Ma Rui , Tian Zhiyuan , Liang Yin , Shi Xuezheng
Published: May 2024

Drainage difficulties in the waterlogged areas of sloping cropland not only impede crop development but also facilitate the formation of erosion gullies, resulting in significant soil and water loss. Investigating the distribution of these waterlogged areas is crucial for comprehending the erosion patterns of sloping cropland and preserving black soil resource. In this study, we built varied models based on two stages (one using only deep learning methods and the other combining object-based image analysis (OBIA) with deep learning methods) to identify waterlogged areas using high-resolution remote sensing data. The results showed that the five deep learning models using original remote sensing imagery achieved precision rates varying from 54.6% to 60.9%. Among these models, the DeepLabV3+-Xception model achieved the highest accuracy, as indicated by an F1-score of 53.4%. The identified imagery demonstrated a significant distinction in the two categories of waterlogged areas: sloping cropland erosion zones and erosion risk areas. The former had obvious borders and fewer misclassifications, exceeding the latter in terms of identification accuracy. Furthermore, the accuracy of the deep learning models was significantly improved when combined with object-oriented image analysis. The DeepLabV3+-MobileNetV2 model achieved the maximum accuracy, with an F1-score of 59%, which was 6% higher than that of the model using only original imagery. Moreover, this advancement mitigated issues related to boundary blurriness and image noise in the identification process. These results will provide scientific assistance in managing and reducing the impact in these places.
Urban Green Spaces’ Influence on Civilization Diseases—Meta-Analysis and Critical Review
Authors: Kaczyńska Małgorzata
Published: May 2024

This study investigates the influence of urban green spaces on the prevalence of overweight/obesity, diabetes, and hypertension. The search was run in the PUBMED database, using the search algorithm including combinations of keywords associated with the two concepts: civilization health problems and urban green spaces. A meta-analysis (for 48 studies) and critical review (for 26 studies) were performed. The meta-analysis results show that the presence, accessibility, and quality of green spaces are associated with the decreased prevalence of overweight/obesity (OR 0.86 (95% CI 0.77–0.95), p < 0.001, I2 99.7%), diabetes (OR 0.83 (95% CI 0.79–0.87), p < 0.001, I2 67.5%), and hypertension (OR 0.77 (95% CI 0.63–0.92), p < 0.001, I2 84.9%). In the children population, the influence of green spaces on overweight is unequivocal (OR 0.88 (95% CI 0.72–1.03), p < 0.001, I2 99.6%) and there is no influence on diabetes control. A green space’s direct influence on systolic or diastolic blood pressure is unequivocal. A green space is associated with a decreased prevalence of civilization diseases. Its positive influence, however, is not so strong in children. The short-term influence of green spaces on blood pressure (e.g., taken as a proxy for mental stress) is unequivocal.
Revisiting Spatial Justice and Urban Parks in the Post-COVID-19 Era: A Systematic Literature Review
Authors: Swapan Mohammad Shahidul Hasan , Aktar Shamima , Maher Jeremy
Published: May 2024

Urban parks, integral to city life, have long contributed to the well-being of residents through various ecosystem services. Previous studies consistently highlighted unequal park distribution and access, and the COVID-19 pandemic has exacerbated these disparities. From a spatial justice perspective, this review examines urban parks’ roles during the pandemic, the impact on equity and access, and how evolving park usage characteristics inform future management challenges. Analysing 53 peer-reviewed studies and 11 online materials from January 2020 to April 2023, this review reveals a significant increase in park visitors during the pandemic, causing challenges in accommodating the surge due to lockdown measures. The findings underscore physical and social justice dimensions, revealing disparities in park access during COVID-19. These challenges prompt reevaluating urban parks’ potential for well-being and ecosystem benefits, advocating for inclusive decision-making to enhance community resilience and socialisation. The COVID-19 crisis highlighted planning and management challenges, emphasising the need for a more sustainable, liveable, and responsive approach to urban park planning.
Assessing the Operational Capability of Disaster and Emergency Management Resources: Using Analytic Hierarchy Process
Authors: Zhang Ke , Lee Jae Eun
Published: May 2024

This study aims to assess the operational capability of disaster and emergency management resources (DEMRs), which is not only critical for effective loss reduction and resilience, but also facilitates the sharing and optimal use of resources for the more effective achievement of sustainable development. This study constructs an evaluation index system of the operational capability of DEMRs, encompassing four key aspects: resource planning, organizational management capability, resource support capability, and information processing capability. It focuses on identifying the factors that influence the operational capability of DEMRs in China and Korea, comparing and analyzing the relative importance and priority of each evaluation domain and indicator within these countries. The results show that the organizational management capability is most significant in China, whereas the resource support capability is prioritized in Korea. A comparative analysis of the local weight of indicators within each domain revealed the largest discrepancy between China and Korea in the information processing capability domain. This study concludes by calculating global weights, identifying the fast response capability and resource allocation capability as the most impactful factors on the operational capability of DEMRs, and highlighting their critical role in disaster and emergency management.
Urban Morphology Influencing the Urban Heat Island in the High-Density City of Xi’an Based on the Local Climate Zone
Authors: Wang Chongqing , Zhang He , Ma Zhongxu , Yang Huan , Jia Wenxiao
Published: May 2024

Urban form plays a critical role in enhancing urban climate resilience amidst the challenges of escalating global climate change and recurrent high-temperature heatwaves. Therefore, it is crucial to study the correlation between urban spatial form factors and land surface temperature (LST). This study utilized Landsat 8 remote sensing data to estimate LST. Random forest nonlinear analysis was employed to investigate the interaction between the urban heat island (UHI) and six urban morphological factors: building density (BD), floor area ratio (FAR), building height (BH), fractional vegetation coverage (FVC), sky view factor (SVF), and impervious surface fraction (ISF), within the framework of local climate zones (LCZs). Key findings revealed that Xi’an exhibited a significant urban heat island effect, with over 10% of the study area experiencing temperatures exceeding 40 °C. Notably, the average LST of building-class LCZs (1-6) was 3.5 °C higher than that of land cover-class LCZs (A-C). Specifically, compact LCZs (1-3) had an average LST 3.02 °C higher than open LCZs (4-6). FVC contributed the most to the variation in LST, while FAR contributed the least. ISF and BD were found to have a positive impact on LST, while FVC and BH had a negative influence. Moreover, SVF was observed to positively influence LST in the compact classes (LCZ2-3) and open low-rise class (LCZ6). In the open mid-rise class (LCZ5), SVF and LST showed a U-shaped relationship. There is an inverted U-shaped relationship between FAR and LST, with the inflection point occurring at 1.5. The results of nonlinear analysis were beneficial in illustrating the complex relationships between LST and its driving factors. The study’s results highlight the effectiveness of utilizing LCZ as a detailed approach to explore the relationship between urban morphology and urban heat islands. Recommendations for enhancing urban climate resilience include strategies such as increasing vegetation coverage, regulating building heights, organizing buildings in compact LCZs in an “L” or “I” shape, and adopting an “O” or “C” configuration for buildings in open LCZs to aid planners in developing sustainable urban environments.
Engineering Drawing Applied to the Study of the Design of a Two-Cylinder Entablature Steam Engine with Parallel Motion Crosshead
Authors: Rojas-Sola José , Barranco-Molina Juan
Published: May 2024

This article presents an investigation into a historical invention consisting of a stationary steam engine designed by Henry Muncaster: a two-cylinder entablature steam engine with parallel motion crosshead. The present interdisciplinary research, based on the theoretical and methodological concepts of engineering drawing and computer-aided design, has allowed us to understand the operation of this invention from the 3D CAD model of the invention obtained thanks to the original drawings published in the magazine Model Engineer in 1957 and reproduced in 2017, since there is no descriptive information related to the invention. However, there have been drawbacks in the geometric modeling process since the dimensions of some components did not exist and in other cases they were erroneous. For this reason, dimensional, geometric and movement constraints (degrees of freedom) had to be applied so that said 3D CAD model would be coherent and functional, and an interference analysis also had to be performed. Finally, the existing symmetry in the arrangement of the cylinders and the crosshead has been discovered, it being essential to guarantee that the forces and movements are uniform on both sides of the steam engine, and allowing the work to be carried out in a more balanced manner by reducing vibrations and improving the overall efficiency of the invention.
On Uniformly Starlike Functions with Respect to Symmetrical Points Involving the Mittag-Leffler Function and the Lambert Series
Authors: Salah Jamal
Published: May 2024

The aim of this paper is to define the linear operator based on the generalized Mittag-Leffler function and the Lambert series. By using this operator, we introduce a new subclass of β-uniformly starlike functions ΤJ(αi). Further, we obtain coefficient estimates, convex linear combinations, and radii of close-to-convexity, starlikeness, and convexity for functions f∈ΤJ(αi). In addition, we investigate the inclusion conditions of the Hadamard product and the integral transform. Finally, we determine the second Hankel inequality for functions belonging to this subclass.
A Screening Study Identified Decitabine as an Inhibitor of Equid Herpesvirus 4 That Enhances the Innate Antiviral Response
Authors: Normand Camille , Thieulent Côme J. , Fortier Christine , Sutton Gabrielle , Senamaud-Beaufort Catherine , Jourdren Laurent , Blugeon Corinne , Vidalain Pierre-Olivier , Pronost Stéphane , Hue Erika S.
Published: May 2024

Equid herpesvirus 4 (EHV-4) is a common respiratory pathogen in horses. It sporadically induces abortion or neonatal death. Although its contribution in neurological disorders is not clearly demonstrated, there is a strong suspicion of its involvement. Despite preventive treatments using vaccines against EHV-1/EHV-4, the resurgence of alpha-EHV infection still constitutes an important threat to the horse industry. Yet very few studies have been conducted on the search for antiviral molecules against EHV-4. A screening of 42 antiviral compounds was performed in vitro on equine fibroblast cells infected with the EHV-4 405/76 reference strain (VR2230). The formation of cytopathic effects was monitored by real-time cell analysis (RTCA), and the viral load was quantified by quantitative PCR. Aciclovir, the most widely used antiviral against alpha-herpesviruses in vivo, does not appear to be effective against EHV-4 in vitro. Potential antiviral activities were confirmed for eight molecules (idoxuridine, vidarabine, pritelivir, cidofovir, valganciclovir, ganciclovir, aphidicolin, and decitabine). Decitabine demonstrates the highest efficacy against EHV-4 in vitro. Transcriptomic analysis revealed the up-regulation of various genes implicated in interferon (IFN) response, suggesting that decitabine triggers the immune antiviral pathway.
Groundwater Recharge Assessment in Central Benin: The Case of the Collines Region (West Africa)
Authors: Kpegli Kodjo Apelete Raoul , Adandedji Firmin , Ahouandogbo Cintia , Djihouessi Metogbe Belfrid , Hounkpe Jean , N’Tcha M’Po Yèkambèssoun , Bossa Aymar Yaovi , Alassane Abdoukarim , Sintondji Luc Olivier , Mama Daouda , Boukari Moussa
Published: May 2024

The objective of this study was to assess groundwater recharge in the hard-rock central region of Benin so as to compare it with the water needs of the local population. To reach this objective, we applied the Water Table Fluctuation (WTF) method, which requires long-term monitoring of groundwater level fluctuations. Groundwater level time series were used in combination with other data (including time series of surface water discharge and rainfall) to estimate groundwater recharge but also to shed further light on the relationship between surface water and groundwater. The results demonstrated that the minimum inter-annual groundwater recharge amount is about 1.09 × 109 m3, which is enough to cover the basic water needs of the local population. It should be highlighted that in sub-regions where the density of the population is high, water shortage can still occur with the above estimated groundwater recharge amount. This study has also illustrated that when applying the WTF method, sites with a highly uncertain specific yield can be detected.
Numerical Analysis of Dynamic Response in Large Caissons during Wet-towing after Cable Breakage
Authors: Gu Haoyang , Xu Qingyun , Wang Huakun , Feng Weibing
Published: May 2024

Variable and complex marine environmental loads combined with wave resistance and the insufficient controllability of large caisson structures pose serious challenges during maritime towing. Cable breakage events are common, and improper behaviors could give rise to a variety of accidents. This work explored the dynamic responses of large caisson structures following towing cable breakage under irregular waves combined with harsh currents. Two types of cable breakage, i.e., main bridle and towing bridle breakage, were taken into account. Four potential wave–current combinations were assumed for each situation according to direction. The obtained results show that drag rope breakage could give rise to lateral shifts in the structure, which can become a serious condition when exposed to angled waves. Additionally, following breakage, significant force fluctuations took place in the remaining intact cables. For main cable breakage, both lateral and backward displacements were observed in the structure, which gradually entered a ‘flowing with the wave’ state. Furthermore, under the two abovementioned cable breakage conditions, the structure air gap consistently exceeded 2.3 m, ignoring the possibility of a wave slamming event.
Research on the Reconstruction of Aquatic Vegetation Landscape in Coal Mining Subsidence Wetlands Based on Ecological Water Level
Authors: Luo Pingjia , Zhang Mengchu , Zhou Shiyuan
Published: May 2024

The eastern region of the Huang-Huai area is vital for China’s coal production, with high water table mining causing significant surface subsidence and the formation of interconnected coal mining subsidence wetlands. Restoring these wetlands is crucial for biodiversity, environmental quality, and sustainable development. Aquatic vegetation plays a crucial role in wetland ecosystems, underscoring its importance in restoration efforts. Understanding and managing water level fluctuations is essential due to their impact on vegetation. This study examines the Qianshiliying coal mining subsidence wetland in the Yanzhou Mining Area, China, with the goal of devising a water level regulation plan based on the minimum ecological water level to improve the growth and recovery of aquatic vegetation. The research delves into landscape ecological restoration techniques for aquatic vegetation in coal mining subsidence wetlands in the eastern Huang-Huai region, emphasizing the importance of water level management. The results reveal that the minimum ecological water level in the Qianshiliying coal mining subsidence wetland is 32.50 m, and an area of 78.09 hectares is suitable for the reconstruction of aquatic vegetation. This paper utilizes lake morphology, minimum biological space, and water level demand methods for aquatic plants in the landscape to promote restoration of coal mining subsidence wetlands. A notable strength of this approach is its ability to quantitatively predict the survival range and area of aquatic vegetation in these wetlands, enabling a more scientifically informed restoration of ecological balance and promoting landscape ecological restoration in the eastern Huang-Huai region.
Assessment of Groundwater Vulnerability to Seawater Intrusion Using GALDIT, SITE and SIVI Methods in Laspias River Coastal Aquifer System, NE Greece
Authors: Pliaka Christina , Gkiougkis Ioannis , Karasogiannidis Dimitrios , Angelidis Panagiotis , Kallioras Andreas , Pliakas Fotios-Konstantinos
Published: May 2024

This paper presents the investigation of groundwater vulnerability to seawater intrusion of the aquifer system in the coastal area of Laspias River, NE Greece, for the year 2023, by applying the GALDIT, SITE and SIVI methods, in the context of the groundwater management of the area. The relevant research works include the collection and analysis of data and information regarding the geological and geomorphological environment, as well as the hydrogeological system of the area. The calculation of the GALDIT, SITE and SIVI indices values is described, and the results from the application of the methods are presented, as well as the design of relevant groundwater vulnerability maps of the study area. This paper concludes with findings and proposals useful for the reliable assessment of the hydrogeological regime of the wider study area.
Färgvariation hos vattenpiplärka Anthus spinoletta i vinterdräkt
Authors: Andersson Reino
Published: May 2024

This study of colour variation on Water Pipit Anthus spinoletta in winter plumage, is based on photos of 93 individuals from southern Sweden. Using moulting criteria, the birds were aged from the photographs, and the presence or absence of five specific plumage characteristics were recorded. Twelve individuals in this study confirm the hypothesis that adult Water Pipits show a distinct combination of plumage traits during winter. However, the presence of these plumage traits varied in younger birds in their first winter plumage. Among the 81 individuals classified as first winter plumage, 23 (28%) displayed all “adult characteristics”, 32 (40%) one to four of the characteristics, while 26 (32%) lacked all “adult characteristics”. The latter group thus lacked a gray nape/crown, whitish supercilium, and lighter brown colouration of the mantle/scapulars. Ever since the first Swedish records in the mid-1990s, there have been ongoing discussions regarding species-specific characters in Water Pipits. The present quantification of colour variation in different age groups complements previous criteria for a reliable species identification of Water Pipits in winter plumage.