bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of Hydrological and Climatic Changes on Tree Growth in Narew National Park, NE Poland, over the Past 50 Years
Authors: Piętka Sławomir , Misiukiewicz Wojciech , da Costa Joao M.
Published: August 2024

Over the last 50 years, groundwater levels have been decreasing and air temperatures have been increasing in Poland. Maintaining this trend may make it impossible to maintain hydrogenic habitats in good condition. Reactions to ongoing climate change recorded in tree rings may be a good indicator describing the degree of this threat. The aim of this study was to determine the influence of climatic and hydrological changes on the growth of scotch pine (Pinus sylvestris L.) and black alder (Alnus glutinosa (L.) Gaertn) in the Narew National Park over past 50 years. The research was based on tree increment cores extracted from 42 pine trees and 57 alder trees that were randomly selected and ranged in age from 25 to 88 years, as well as climatic and hydrological data. Standardised data (5-year index) were analysed by species, generation (Y—21–40 years, M—41–60, O—61–90), and decade using correlation analysis. The results of the study show that pine responded more strongly to changes in air temperature and changes in precipitation totals, while alder growth was more strongly related to fluctuations in the water level of the Narew River and changes in precipitation totals. Our research showed that differences in response to environmental factors also occur between tree generations. The decrease in the water level of the Narew River that occurred over the last 50 years did not adversely affect the condition of the trees. Analysis of DBH growth rates showed that the younger generations (Y, M) grow faster than the older generation (O). This is positive news for managers of commercial and protected forests, but accelerated tree growth may be associated with specific consequences, such as increased wind damage as a result of reduced wood density or reduced sensitivity of trees to climate and hydrological changes.
The Production of Marandu Grass (Urochloa brizantha) Extracts as a Natural Modifier of Rumen Fermentation Kinetics Using an In Vitro Technique
Authors: Freitas Rafaela Scalise Xavier de , da Silva Janaina Silveira , Furtado Althieres José , Perna Junior Flavio , de Oliveira Alessandra Lopes , Bueno Ives Cláudio da Silva
Published: August 2024

The ethanolic (EE) and hydroalcoholic (HE) extracts of Urochloa brizantha concentrations were developed with the aim of evaluating their effect on rumen fermentation using an in vitro gas production technique. The EE and HE presented 3.62 and 5.38 mg protodioscin/mL, respectively. Ten treatments were evaluated in a completely randomized factorial arrangement (2 × 4 + 2), where the main effects were two extracts (EE and HE) and four levels (50, 100, 150, and 200 mL of extract/kg of DM) plus two controls: one positive (25 ppm of monensin–MON) and one (with no additives–CTL). The extract treatments (EXT, EE, and HE) reduced colonization time by 33.59% compared to the MON. IVDMD (p < 0.001) and IVOMD (p < 0.0001) were negatively affected by EXT addition when compared to CTL. Additionally, EXT reduced the proportion of propionic acid and increased the proportion of butyric acid in relation to CTL and MON treatments. Both EE and HE extracts of U. brizantha were able to alter rumen fermentation kinetic, with HE showing a higher concentration of protodioscin. Further research is needed to optimize extraction methodologies, comprehensively profile secondary compounds, and conduct trials with varying doses to effectively assess the viability of U. brizantha extract as an additive.
Role of Wilting Time on the Chemical Composition, Biological Profile, and Fermentative Quality of Cereal and Legume Intercropping Silage
Authors: Dias Cristiana Maduro , Nunes Hélder , Aguiar Mariana , Pereira Arnaldo , Madruga João , Borba Alfredo
Published: August 2024

Agricultural production in the Azores primarily focuses on the livestock sector, notably, dairy production, where cows graze year-round in a rotational system. To maintain pasture productivity, farmers often rely on synthetic nitrogen fertilizers, which have adverse environmental impacts like ammonia emissions and nitrate leaching. Alternatively, nitrogen-fixing crops like legumes are explored as green manures to enhance soil quality and reduce dependence on chemical fertilizers. The traditional practice of using mixed forages of legumes and grasses, known as “outonos” or intercrops, has been crucial but is declining over time. These mixtures include plants such as lupins, Vicia faba, oats, and vetch, noted for their adaptability and nitrogen-fixing ability. Due to the high perishability of these crops, effective conservation strategies like ensiling are essential to preserve forage nutritional quality through controlled fermentation. This study evaluates the productivity and quality of intercrop forages in the Azores, focusing on fresh samples and silage prepared with wilting times of 0, 24, 48, and 96 h, followed by comprehensive chemical analyses. Results showed significant changes in fiber components (neutral detergent fiber, acid detergent fiber, and acid detergent lignin) with increased wilting time, leading to reduced digestibility. However, wilting improved dry matter content.
EHD Instabilities in Two Layers of Insulating and Conducting Immiscible Liquids Subjected to Unipolar Charge Injection
Authors: Koulova Dantchi , Atten Pierre
Published: August 2024

In this paper, the instability of two layers of insulating and conducting immiscible liquids separated by a deformable interface and subjected to unipolar injection is examined. Taking into account the slight deformation of the interface between the two liquids, a system of equations and boundary conditions is derived at marginal state. Non zero numerical solutions for both layers exist only for eigenvalues of the instability parameter T, which depends on the following parameters: injection level C, Bond number Bo, a new non-dimensional parameter P proportional to interfacial tension and the ratio of the layers’ thickness and of liquids viscosity. The variations in the instability criterion Tc, corresponding to the smallest eigenvalue, are examined in detail as a function of the main characteristic parameters C, P and the Bond number. We find that for some values of P, two instability mechanisms convective and interfacial ones can take place. When the strength of interfacial tension or the liquid thickness ratio is very low, the critical number tends to a value corresponding to interfacial instability. The influence of injection-induced convection in the insulating layer and the effect of interfacial deformation on interfacial instability are also discussed.
A Microbial Phenomics Approach to Determine Metabolic Signatures to Enhance Seabream Sparus aurata Traceability, Differentiating between Wild-Caught and Farmed
Authors: Nerini Marta , Russo Alessandro , Decorosi Francesca , Meriggi Niccolò , Viti Carlo , Cavalieri Duccio , Marvasi Massimiliano
Published: August 2024

Background: The need for efficient and simplified techniques for seafood traceability is growing. This study proposes the Biolog EcoPlate assay as an innovative method for assessing wild and farmed Sparus aurata traceability, offering advantages over other molecular techniques in terms of technical simplicity. Methods: The Biolog EcoPlate assay, known for its high-throughput capabilities in microbial ecology, was utilized to evaluate the functional diversity of microbial communities from various organs of S. aurata (seabream) from the Mediterranean area. Samples were taken from the anterior and posterior gut, cloaca swabs and gills to distinguish between farmed and wild-caught individuals. The analysis focused on color development in OmniLog Units for specific carbon sources at 48 h. Results: Gills provided the most accurate clusterization of sample origin. The assay monitored the development of color for carbon sources such as α-cyclodextrin, D-cellobiose, glycogen, α-D-lactose, L-threonine and L-phenylalanine. A mock experiment using principal component analysis (PCA) successfully identified the origin of a blind sample. Shannon and Simpson indexes were used to statistically assess the diversity, reflecting the clusterization of different organ samples; Conclusions: The Biolog EcoPlate assay proves to be a quick, cost-effective method for discriminate S. aurata traceability (wild vs. farmed), demonstrating reliable reproducibility and effective differentiation between farmed and wild-caught seabream.
Fast and Reliable On-Site Quality Assessment of Essential Raw Brewing Materials Using MicroNIR and Chemometrics
Authors: Gullifa Giuseppina , Albertini Chiara , Papa Elena , Petrucci Rita , Di Matteo Paola , Bortolami Martina , Materazzi Stefano , Risoluti Roberta
Published: August 2024

The interest in the quality control of the raw materials, intermediates, and final products, as well as production methods, of beer has increased significantly in recent decades due to the needs and expectations of consumers. Increasing in the industrialization and globalization of beer supply chains led to a need for novel analytical tools suitable for the rapid and reliable characterization of the materials involved. In this study, an ultracompact instrument operating in the NIR region of the spectrum, microNIR, was tested for the chemical investigation of barley malts. The essential raw materials for brewing require careful control since they deeply affect the characteristic flavor and taste of the final products. Therefore, a robust prediction model able to classify base and specialty barley malts was developed starting from NIR measurements. Soft Independent Class Analogy (SIMCA) was selected as the chemometric technique for the optimization of two prediction models, and ground and sieved materials were investigated using spectroscopy. The microNIR/chemometric approach proposed in this study permitted the correct prediction of the malt samples included in the external validation set, providing false positive and false negative rates no higher than 3.41% and 0.25%, respectively, and confirming the feasibility of the novel analytical platform.
Fatty Acid Profile and Physicochemical Properties of Moringa oleifera Seed Oil Extracted at Different Temperatures
Authors: Cervera-Chiner Lourdes , Pageo Sergio , Juan-Borrás Marisol , García-Mares Francisco José , Castelló María Luisa , Ortolá María Dolores
Published: August 2024

Moringa oleifera Lam. (Moringaceae) is a tropical plant native to India. It is widespread throughout the southern hemisphere, with great adaptability to high temperatures and water scarcity. Its seeds have a great amount of oil with a high content of oleic acid, quite similar to olive oil. Therefore, this study is focused on the extraction of oil from moringa seeds via an automatic screw press extractor at different temperatures (70, 100, 130, 160, 190, and 220 °C) and on the analysis of its acidity, acid value, peroxide value (PV), saponification value (SV), iodine value (IV), optical properties, and fatty acids profile. The results showed that the oil yield was 19 ± 3% regardless of the temperature applied. The oil was stable from the oxidative point of view, with a high acidity. Temperature extraction did not significantly affect the SV and the IV. However, the extraction temperature should be below 190 °C to obtain a translucent and luminous oil with light yellow tones. The oil contains high levels of unsaturated fatty acids, especially oleic acid (ω9) (up to 77.8%) and linolenic acid (ω3) (3.4%). On the other hand, behenic (7%), palmitic (6%), stearic (5%), and arachidic (0.2%) were the dominant saturated acids. The good properties of moringa oil make it a good, sustainable alternative to vegetable oils.
The Density and Ionization Profiles of Optically Dark and High-Redshift GRBs Probed by X-ray Absorption
Authors: Arumaningtyas Eka Puspita , Al Rasyid Hasan , Dainotti Maria Giovanna , Yonetoku Daisuke
Published: August 2024

The X-ray column density (NHX) of gamma-ray bursts (GRBs) can probe the local environment of their progenitors over a wide redshift range. Previous work has suggested an increasing trend as a function of redshift. The relevance of this current analysis relies on investigating the selection bias method, such as the effect of the X-ray spectrum in high-redshift GRBs, which complicates the measurement of small NHX; this has yet to be fully evaluated or discussed elsewhere. In this work, we evaluated these effects through simulations to define appropriate observational limits in the NHX versus redshift plane. We then applied a one-sided nonparametric method developed by Efron and Petrosian. Within the framework of this method, we investigated the redshift dependence of NHX and the local distribution function. Our results show that the evolution of NHX with redshift firmly exists with a significance of more than four sigma and follows a power law of (1+z)1.39(+0.22,−0.27). Based on these analyses and previous studies, the GRB progenitor mass varies but is more massive in the high-redshift environment and has a higher gas column density. This suggests that part of the luminosity evolution of GRBs, which has been widely reported, may be due to the evolution of the progenitor’s mass. Using the same method, we demonstrate that optically dark GRBs show a consistent evolution: (1+z)1.15(+0.67,−0.83). By applying the Kolmogorov–Smirnov (KS) test, it is shown that optically dark GRBs have statistically identical flux and photon index distributions compared to normal GRBs, but the NHX is systematically larger. This result suggests that the darkness of some GRB populations is not due to an intrinsic mechanism, but rather because a higher density surrounds them.
Acute Kidney Injury in Rhabdomyolysis: A 5-Year Children’s Hospital Network Study
Authors: Pinto Jamie M. , Ison Gregory , Kasselman Lora J. , Naganathan Srividya
Published: August 2024

Rhabdomyolysis is a skeletal muscle injury that can cause myoglobinuria and acute kidney injury (AKI). Risk factors for AKI in children are not clearly understood with no standardized treatment guidelines for rhabdomyolysis. Our study explores factors associated with AKI and management of pediatric patients with rhabdomyolysis. Medical records from a children’s hospital network over a 5-year period were retrospectively reviewed. The results are described with respect to the presence or absence of AKI. Of the 112 patients who met the inclusion criteria, AKI incidence was 7.1% (n = 8), with all affected patients having exertional etiology. The overall mean age was 13.5 years; patients without AKI were younger than patients with AKI (13.3 versus 17; p < 0.001). Using regression models for hypothesis generation, we found that patients with AKI were more likely to be older (OR = 1.44, 95%CI [1.11–2.19]; p = 0.03), have myoglobinuria (OR = 22.98, 95%CI [2.05–432.48]; p = 0.02), and have received intravenous bicarbonate (OR = 16.02, 95%CI [1.44–228.69]; p = 0.03). In our study, AKI was uncommon and associated with older age, myoglobinuria and bicarbonate treatment. Larger, prospective studies are needed to further understand AKI risk factors and optimal management of pediatric rhabdomyolysis.
Methods and Target Values Used to Evaluate Teaching Concepts, with a Particular Emphasis on the Incorporation of Digital Elements in Higher Education: A Systematic Review
Authors: Morat Tobias , Hollinger Anna
Published: August 2024

Previous evaluations of teaching quality have not considered the integration of digital elements. This systematic review was conducted in accordance with the PRISMA guidelines and offers a critical examination of the integration of digital elements in university teaching quality evaluations. The objective is to provide a comprehensive and systematic overview of the methods and target values used for special attention on the incorporation of digital elements in teaching concepts. This review analyzed 22 articles published between 2004 and 2023 from a pool of 11,851 manuscripts. The studies were classified into evidence levels A to C based on the clarity of quality criteria and documentation of measurement instruments. The findings indicate a significant gap in comprehensive quality criteria and instrument references. Self-developed questionnaires and performance examinations were prevalent, mostly classified under the lowest evidence level (C). A limited number of studies focused on psychological outcomes and the evaluation of digital teaching concepts, fulfilling all criteria for the highest evidence level (A). The results indicate a focus on using open-ended questions, interviews, and feedback mechanisms to gain insights into students’ perceptions, which are essential for refining teaching concepts. There is a need to develop and validate evidence-based measurement techniques to better accommodate digital elements integration in teaching evaluations for future university pedagogy enhancements. The findings of this review provide a robust foundation for this purpose. This systematic review has been registered on INPLASY (INPLASY202460060).
DFT Modeling of Coordination Polymerization of Polar Olefin Monomers by Molecular Metal Complexes
Authors: Zhao Yanan , Zhang Zhenli , Luo Yi
Published: August 2024

Introducing polar functional groups into polyolefin chains through polar olefin monomer coordination (co)polymerization can directly and significantly improve the surface properties of polymer materials and expand their application range. Therefore, the related research has always received considerable attention from both academia and industry. Many experimental studies have been reported in this field, and molecular metal complexes have shown high catalytic activity and selectivity in polar olefin monomer polymerizations. Although considerable DFT calculations have also been conducted for better understanding of the (co)polymerization performance, the factors governing the activity, selectivity, and molecular weight of resulting polymers are still ambiguous. This review mainly focuses on the DFT studies of polar olefin monomer coordination (co)polymerization catalyzed by molecular metal complexes in recent years, discussing the chain initiation and propagation, the origin of polymerization activity and selectivity, and the specific role of additives in the (co)polymerization reactions.
Hypertension-Mediated Organ Damage in Relation to Severity of Chronic Low Back Pain in Hypertensive Patients
Authors: Skrzypek Maciej , Kolec Rafał , Słaboszewski Michał , Góra Katarzyna , Olszanecka Agnieszka , Wróbel Piotr , Stolarz-Skrzypek Katarzyna , Rajzer Marek W.
Published: August 2024

Introduction: Chronic pain triggers a stress response, which results in increased blood pressure (BP). We investigated whether chronic low back pain (cLBP) in hypertensive patients is associated with an increased risk of hypertension-related organ damage. Methods: We studied 85 consecutive hypertensive patients with a median age of 62 years (55–67), who suffered from cLBP, the severity of which was evaluated according to the Oswestry Disability Index (ODI). Patients underwent transthoracic echocardiography, arterial ultrasonography and vascular tonometry. We assessed carotid artery atherosclerotic plaques, along with carotid-femoral pulse wave velocity (cf-PWV) and left ventricular mass index (LVMI). Results: An equal to or higher than median (16 points) ODI score in 48 subjects (56.5%) was associated with the presence of carotid artery plaques (p = 0.014). In multivariate analysis, after adjusting for covariates, the presence of carotid artery plaques remained independently associated with an ODI score equal to or higher than the median (OR, 3.71; 95% CI, 1.04–13.25; p = 0.044). None of the other analyzed parameters of hypertension-related organ damage demonstrated a significant relationship with the ODI score. Conclusions: We observed that more severe cLBP is associated with a higher prevalence of carotid artery atherosclerotic plaques among hypertensive patients.
Large Language Model Prompting Techniques for Advancement in Clinical Medicine
Authors: Shah Krish , Xu Andrew Y. , Sharma Yatharth , Daher Mohammed , McDonald Christopher , Diebo Bassel G. , Daniels Alan H.
Published: August 2024

Large Language Models (LLMs have the potential to revolutionize clinical medicine by enhancing healthcare access, diagnosis, surgical planning, and education. However, their utilization requires careful, prompt engineering to mitigate challenges like hallucinations and biases. Proper utilization of LLMs involves understanding foundational concepts such as tokenization, embeddings, and attention mechanisms, alongside strategic prompting techniques to ensure accurate outputs. For innovative healthcare solutions, it is essential to maintain ongoing collaboration between AI technology and medical professionals. Ethical considerations, including data security and bias mitigation, are critical to their application. By leveraging LLMs as supplementary resources in research and education, we can enhance learning and support knowledge-based inquiries, ultimately advancing the quality and accessibility of medical care. Continued research and development are necessary to fully realize the potential of LLMs in transforming healthcare.
Validation of the Scale of Emotional Development-Short (SED-S) in Healthy Adults with an Intellectual Disability
Authors: Meinecke Theresa , Flachsmeyer Miriam , Sappok Tanja
Published: August 2024

Background: The Scale of Emotional Development-Short (SED-S) assesses the level of emotional development (ED) of persons with intellectual disability (ID) in eight domains across five stages with reference ages from 0 to 12 years. The aim of this study was to apply and validate the SED-S in a sample of healthy adults with ID. Method: Eighty-three mentally healthy adults with ID were assessed using the SED-S. Factor analysis, Cronbach’s alpha, and correlational analyses were used to test the scale’s internal structure and associations. Results: The results showed that the eight-domain structure of the SED-S is supported by strong inter-domain correlations, a high Cronbach’s alpha, and a one-factor confirmatory factor analysis. The SED-S was associated with the severity of ID but not with age or gender. Conclusions: The SED-S can be used in non-clinical settings to better understand and meet the emotional needs of adults with ID.
Comparison of Biomechanical and Microstructural Properties of Aortic Graft Materials in Aortic Repair Surgeries
Authors: Sun Haoliang , Cheng Zirui , Guo Xiaoya , Gu Hongcheng , Tang Dalin , Wang Liang
Published: August 2024

Mechanical mismatch between native aortas and aortic grafts can induce graft failure. This study aims to compare the mechanical and microstructural properties of different graft materials used in aortic repair surgeries with those of normal and dissected human ascending aortas. Five types of materials including normal aorta (n = 10), dissected aorta (n = 6), human pericardium (n = 8), bovine pericardium (n = 8) and Dacron graft (n = 5) were collected to perform uniaxial tensile testing to determine their material stiffness, and ultimate strength/stretch. The elastin and collagen contents in four tissue groups except for Dacron were quantified by histological examinations, while the material ultrastructure of five material groups was visualized by scanning electron microscope. Statistical results showed that three graft materials including Dacron, human pericardium and bovine pericardium had significantly higher ultimate strength and stiffness than both normal and dissected aortas. Human and bovine pericardia had significantly lower ultimate stretch than native aortas. Histological examinations revealed that normal and diseased aortic tissues had a significantly higher content of elastic fiber than two pericardial tissues, but less collagen fiber content. All four tissue groups exhibited lamellar fiber ultrastructure, with aortic tissues possessing thinner lamella. Dacron was composed of densely coalesced polyethylene terephthalate fibers in thick bundles. Aortic graft materials with denser fiber ultrastructure and/or higher content of collagen fiber than native aortic tissues, exhibited higher ultimate strength and stiffness. This information provides a basis to understand the mechanical failure of aortic grafts, and inspire the design of biomimetic aortic grafts.
AI Use in Mammography for Diagnosing Metachronous Contralateral Breast Cancer
Authors: Adachi Mio , Fujioka Tomoyuki , Ishiba Toshiyuki , Nara Miyako , Maruya Sakiko , Hayashi Kumiko , Kumaki Yuichi , Yamaga Emi , Katsuta Leona , Hao Du , Hartman Mikael , Mengling Feng , Oda Goshi , Kubota Kazunori , Tateishi Ukihide
Published: August 2024

Although several studies have been conducted on artificial intelligence (AI) use in mammography (MG), there is still a paucity of research on the diagnosis of metachronous bilateral breast cancer (BC), which is typically more challenging to diagnose. This study aimed to determine whether AI could enhance BC detection, achieving earlier or more accurate diagnoses than radiologists in cases of metachronous contralateral BC. We included patients who underwent unilateral BC surgery and subsequently developed contralateral BC. This retrospective study evaluated the AI-supported MG diagnostic system called FxMammo™. We evaluated the capability of FxMammo™ (FathomX Pte Ltd., Singapore) to diagnose BC more accurately or earlier than radiologists’ assessments. This evaluation was supplemented by reviewing MG readings made by radiologists. Out of 1101 patients who underwent surgery, 10 who had initially undergone a partial mastectomy and later developed contralateral BC were analyzed. The AI system identified malignancies in six cases (60%), while radiologists identified five cases (50%). Notably, two cases (20%) were diagnosed solely by the AI system. Additionally, for these cases, the AI system had identified malignancies a year before the conventional diagnosis. This study highlights the AI system’s effectiveness in diagnosing metachronous contralateral BC via MG. In some cases, the AI system consistently diagnosed cancer earlier than radiological assessments.
Mirror, Mirror on the Wall: A Meta-Analysis on the Validity of Self-Assessed Intelligence through the Lens of the Multiverse
Authors: Patzl Sabine , Oberleiter Sandra , Pietschnig Jakob
Published: August 2024

Examining the relationship between self-assessed intelligence (SAI) and psychometric intelligence (IQ) is essential for understanding how people’s self-evaluations reflect their actual intelligence. Various factors, such as SAI measurement methods, participant characteristics, and testing conditions have been hypothesized to moderate the SAI–IQ link, yet the generality of this association remains unclear. Here, we provide evidence for SAI and IQ associations based on 278 effect sizes from 115 independent samples (N = 36,833) using a multi-level meta-analysis, revealing a moderate positive correlation (r = 0.30; 95% CI [0.27, 0.33]). Multiverse analyses demonstrated remarkable stability of this effect, with most summary effect specifications yielding significant positive correlations (96%), averaging r = 0.32. Notably, ability domain and sample type emerged as significant moderators, with numerical ability showing stronger correlations compared to general cognitive, verbal, and spatial abilities. Importantly, our study found that correlations in student samples were significantly higher than those in general samples. Our findings show a moderate positive association of SAI with IQ, unaffected by participant sex, publication year, administration order, neuroticism, and self-assessment method, yet significantly moderated by ability domain and sample type. Our results illustrate the importance of feedback in educational settings to help students accurately assess their cognitive abilities.
The Suppression of Flow-Induced Vibrations for a Single and Two Tandem-Arrangement Cylinders Using Three Splitter Plates
Authors: Hu Zhongming , Wang Jiasong , Sun Yuankun , Lin Ke
Published: August 2024

Some very useful methods for suppressing the flow-induced vibration (FIV) of a single cylinder are known to potentially have a limited efficiency for tandem-arrangement cylinders. In this paper, three splitter plates uniformly attached around a cylinder with an angle of 120° are proposed to suppress the FIVs of both a single cylinder and two tandem-arrangement cylinders in a wind tunnel at Re = 4000–45,200. The splitter plates’ length to diameter ratios, L/Ds (where L is the length of the splitter plate and D is the cylinder diameter), are set from 0.1 to 0.8. The results show that the proposed method not only effectively suppresses the vortex-induced vibration (VIV) for a single cylinder, but also successfully mitigates the wake-induced galloping (WIG) for two tandem-arrangement cylinders. The vibrations of the single cylinders are effectively suppressed, consistently achieving suppression efficiencies over 95% for L/Ds = 0.2–0.8, with a notable peak efficiency of 98.4% at L/D = 0.2. For the two tandem-arrangement cylinders at S/D = 4.0 (where S is the center-to-center spacing between the two cylinders), the suppression efficiencies of the upstream cylinder exceed 96% for L/D = 0.2–0.8, with an optimal efficiency of 97.4% at L/D = 0.6. The downstream cylinder exhibits vibration only at L/Ds = 0.1, 0.2, and 0.4, resulting in suppression efficiencies of 80.3%, 67.1%, and 91.0%. The vibrations remain fully suppressed throughout the entire reduced velocity range for L/Ds = 0.6–0.8, reaching an optimal efficiency of 98.7% at L/D = 0.6. Three regimes of fs/fn characteristics can be classified for the single cylinder, and the wake structures show that shear layers develop along the front plate before attaching on the cylinder and are then offset to either side of the cylinder by the two rear splitter plates, contributing to the absence of periodic vortex shedding.
CIS: A Coral Instance Segmentation Network Model with Novel Upsampling, Downsampling, and Fusion Attention Mechanism
Authors: Li Tianrun , Liang Zhengyou , Zhao Shuqi
Published: August 2024

Coral segmentation poses unique challenges due to its irregular morphology and camouflage-like characteristics. These factors often result in low precision, large model parameters, and poor real-time performance. To address these issues, this paper proposes a novel coral instance segmentation (CIS) network model. Initially, we designed a novel downsampling module, ADown_HWD, which operates at multiple resolution levels to extract image features, thereby preserving crucial information about coral edges and textures. Subsequently, we integrated the bi-level routing attention (BRA) mechanism into the C2f module to form the C2f_BRA module within the neck network. This module effectively removes redundant information, enhancing the ability to distinguish coral features and reducing computational redundancy. Finally, dynamic upsampling, Dysample, was introduced into the CIS to better retain the rich semantic and key feature information of corals. Validation on our self-built dataset demonstrated that the CIS network model significantly outperforms the baseline YOLOv8n model, with improvements of 6.3% and 10.5% in PB and PM and 2.3% and 2.4% in mAP50B and mAP50M, respectively. Furthermore, the reduction in model parameters by 10.1% correlates with a notable 10.7% increase in frames per second (FPS) to 178.6, thus effectively meeting real-time operational requirements.
Insight into Virulence and Mechanisms of Amphotericin B Resistance in the Candida haemulonii Complex
Authors: Huang Yuyan , Su Yanyu , Chen Xinfei , Xiao Meng , Xu Yingchun
Published: August 2024

The Candida haemulonii complex includes emerging opportunistic human fungal pathogens with documented multidrug-resistance profiles. It comprises Candida haemulonii sensu stricto, Candida haemulonii var. vulnera, Candida duobushaemulonii, Candida pseudohaemulonii, and Candida vulturna. In recent years, rates of clinical isolation of strains from this complex have increased in multiple countries, including China, Malaysia, and Brazil. Biofilm formation, hydrolytic enzymes, surface interaction properties, phenotype switching and cell aggregation abilities, extracellular vesicles production, stress response, and immune evasion help these fungi to infect the host and exert pathological effects. Multidrug resistance profiles also enhance the threat they pose; they exhibit low susceptibility to echinocandins and azoles and an intrinsic resistance to amphotericin B (AMB), the first fungal-specific antibiotic. AMB is commonly employed in antifungal treatments, and it acts via several known mechanisms. Given the propensity of clinical Candida species to initiate bloodstream infections, clarifying how C. haemulonii resists AMB is of critical clinical importance. This review outlines our present understanding of the C. haemulonii complex’s virulence factors, the mechanisms of action of AMB, and the mechanisms underlying AMB resistance.
Personalized Sound Therapy Combined with Low and High-Frequency Electromagnetic Stimulation for Chronic Tinnitus
Authors: Francavilla Beatrice , Marzocchella Giulia , Alagna Arianna , Tilotta Stefania , Di Leo Elisa , Omer Goran Latif , Di Girolamo Stefano
Published: August 2024

This study investigates a novel multimodal treatment for chronic tinnitus, a condition that significantly affects quality of life, by combining personalized sound therapy with both low- and high-frequency electromagnetic wave stimulation. Conducted at Tor Vergata University Hospital in Rome, the research involved 55 patients and employed a portable medical device for therapy delivery. Treatment effectiveness was measured through the Tinnitus Functional Index (TFI), Tinnitus Handicap Inventory (THI), Visual Analogue Scale (VAS), Hyperacusis Questionnaire (HQ), and Short Form-36 Health Survey (SF-36), encompassing initial sound therapy and subsequent multimodal treatment phases. Remarkably, 73% of participants experienced notable improvements in TFI scores, with 39% reporting a significant enhancement of 13 points or more. This improvement was mirrored in secondary outcomes like THI, VAS, and HQ scores, along with certain SF-36 domains, indicating enhanced life quality and reduced tinnitus distress. The study underscored high compliance and no adverse effects, suggesting the combined therapy’s promising potential in chronic tinnitus management. The findings advocate for further research to discern the distinct contributions of each treatment modality, positing that this innovative approach could ameliorate tinnitus symptoms and improve patient well-being, confirming its safety and efficacy.
Ecologically Regenerative Building Systems through Exergy Efficiency: Designing for Structural Order and Ecosystem Services
Authors: Hecht Katharina , Ortega Reboso Abraham , van der Vegt Michelle , Appelman Jaco , Pedersen Zari Maibritt
Published: August 2024

Regenerative design is being increasingly explored in urban environments to counteract and adapt to the changing climate and degradation of ecosystems. A critical success factor for the implementation of regenerative design is the evaluation of urban and building systems in relation to ecological performance and benefits. In biological ecosystems, the availability of high-quality energy, called exergy, and structural order can be used as indicators of the efficiency of on-going ecological processes. Structural order refers to the organization and systematic arrangements of biotic and abiotic elements within an ecosystem based on the available space and interactions with the goal to form a functional system. Ecological processes use the available exergy and generate ecosystem services (ESs) upon which human survival and that of other living organisms depend. In this article, structural order and ESs generation are proposed as indicators for exergy efficiency and accumulation in building systems, respectively, which can evaluate to what extent they are ecologically functional and regenerative. Based on this insight, design strategies are derived from the functioning of ecosystems that describe how buildings could become habitats that host living, non-living, and hybrid systems with optimized thermodynamic efficiency and that can generate ESs. This research suggests that when buildings improve structural order (an ecological concept) and implement ESs generating processes similar to biological ecosystems, they can facilitate regenerative processes more effectively that consume and generate resources and, with this, destroy but also accumulate exergy.
The Impact of Land Marketization on Urban Resilience: Empirical Evidence from Chinese Cities
Authors: Chen Min , Zeng Longji , Deng Yajuan , Chen Shan , Gu Xin
Published: August 2024

Enhancing urban resilience (UR) is the pivotal strategy for achieving sustainable development. Given that land serves as the cornerstone of urban activities, it is imperative to examine the relationship between land marketization (LM) and urban resilience amidst the profound market-oriented land reforms in China. After establishing the conceptual framework of urban resilience, this paper assesses the temporal and spatial dynamics and empirically investigates the impact of land marketization on urban resilience, drawing on data from 282 cities across China, spanning from 2001 to 2021. Our findings reveal several important insights. First, due to its public bidding and competitive pricing mechanisms, land marketization is a powerful measure to foster urban resilience and enables cities to flexibly respond to various challenges and changes. Second, the indirect mechanisms, including optimizing resource allocation, upgrading industrial structure, and fostering technological innovation, are crucial pathways through which land marketization affects urban resilience. Finally, the impact of land marketization on urban resilience varies across regions and city size. Cities with better geographic locations, larger population sizes, and lower administrative levels are more significantly affected than others. These findings reveal the importance of land marketization in strengthening urban resilience, thereby providing theoretical guidance and empirical references for cities to enhance urban resilience through land marketization.
Correction: Păcurar et al. Hepatitis B in Pediatric Population: Observational Retrospective Study in Romania. Life 2024, 14, 348
Authors: Păcurar Daniela , Dinulescu Alexandru , Jugulete Gheorghiță , Păsărică Alexandru-Sorin , Dijmărescu Irina
Published: August 2024

Text Correction [...]
Game Theory for Predicting Stocks’ Closing Prices
Authors: Freitas João Costa , Pinto Alberto Adrego , Felgueiras Óscar
Published: August 2024

We model the financial markets as a game and make predictions using Markov chain estimators. We extract the possible patterns displayed by the financial markets, define a game where one of the players is the speculator, whose strategies depend on his/her risk-to-reward preferences, and the market is the other player, whose strategies are the previously observed patterns. Then, we estimate the market’s mixed probabilities by defining Markov chains and utilizing its transition matrices. Afterwards, we use these probabilities to determine which is the optimal strategy for the speculator. Finally, we apply these models to real-time market data to determine its feasibility. From this, we obtained a model for the financial markets that has a good performance in terms of accuracy and profitability.
Matching and Rewriting Rules in Object-Oriented Databases
Authors: Bergami Giacomo , Fox Oliver Robert , Morgan Graham
Published: August 2024

Graph query languages such as Cypher are widely adopted to match and retrieve data in a graph representation, due to their ability to retrieve and transform information. Even though the most natural way to match and transform information is through rewriting rules, those are scarcely or partially adopted in graph query languages. Their inability to do so has a major impact on the subsequent way the information is structured, as it might then appear more natural to provide major constraints over the data representation to fix the way the information should be represented. On the other hand, recent works are starting to move towards the opposite direction, as the provision of a truly general semistructured model (GSM) allows to both represent all the available data formats (Network-Based, Relational, and Semistructured) as well as support a holistic query language expressing all major queries in such languages. In this paper, we show that the usage of GSM enables the definition of a general rewriting mechanism which can be expressed in current graph query languages only at the cost of adhering the query to the specificity of the underlying data representation. We formalise the proposed query language in terms declarative graph rewriting mechanisms described as a set of production rules L→R while both providing restriction to the characterisation of L, and extending it to support structural graph nesting operations, useful to aggregate similar information around an entry-point of interest. We further achieve our declarative requirements by determining the order in which the data should be rewritten and multiple rules should be applied while ensuring the application of such updates on the GSM database is persisted in subsequent rewriting calls. We discuss how GSM, by fully supporting index-based data representation, allows for a better physical model implementation leveraging the benefits of columnar database storage. Preliminary benchmarks show the scalability of this proposed implementation in comparison with state-of-the-art implementations.
Emerging Cancer Immunotherapies: Cutting-Edge Advances and Innovations in Development
Authors: Maccagno Monica , Tapparo Marta , Saccu Gabriele , Rumiano Letizia , Kholia Sharad , Silengo Lorenzo , Herrera Sanchez Maria Beatriz
Published: August 2024

The rise in biological therapies has revolutionized oncology, with immunotherapy leading the charge through breakthroughs such as CAR-T cell therapy for melanoma and B-ALL. Modified bispecific antibodies and CAR-T cells are being developed to enhance their effectiveness further. However, CAR-T cell therapy currently relies on a costly ex vivo manufacturing process, necessitating alternative strategies to overcome this bottleneck. Targeted in vivo viral transduction offers a promising avenue but remains under-optimized. Additionally, novel approaches are emerging, such as in vivo vaccine boosting of CAR-T cells to strengthen the immune response against tumors, and dendritic cell-based vaccines are under investigation. Beyond CAR-T cells, mRNA therapeutics represent another promising avenue. Targeted delivery of DNA/RNA using lipid nanoparticles (LNPs) shows potential, as LNPs can be directed to T cells. Moreover, CRISPR editing has demonstrated the ability to precisely edit the genome, enhancing the effector function and persistence of synthetic T cells. Enveloped delivery vehicles packaging Cas9 directed to modified T cells offer a virus-free method for safe and effective molecule release. While this platform still relies on ex vivo transduction, using cells from healthy donors or induced pluripotent stem cells can reduce costs, simplify manufacturing, and expand treatment to patients with low-quality T cells. The use of allogeneic CAR-T cells in cancer has gained attraction for its potential to lower costs and broaden accessibility. This review emphasizes critical strategies for improving the selectivity and efficacy of immunotherapies, paving the way for a more targeted and successful fight against cancer.
Mechanical, Corrosion and Wear Characteristics of Cu-Based Composites Reinforced with Zirconium Diboride Consolidated by SPS
Authors: Sulima Iwona , Stępień Michał , Hyjek Paweł , Boczkal Sonia , Kowalik Remigiusz
Published: August 2024

This study aimed to investigate the physical, mechanical, corrosion, and tribological properties of Cu-based composites with varying zirconium diboride content. The composites were successfully consolidated using spark plasma sintering (SPS) at temperatures of 850 °C and 950 °C and a pressure of 35 MPa. The effect of the ZrB2 content and the sintering temperature on the properties of the Cu-based composites was investigated. Scanning electron microscopy (SEM), electron backscatter diffraction (EBSD), and X-ray diffraction were used to analyse microstructure evolution in copper matrix composites. Microhardness tests were used to evaluate mechanical properties. Wear behaviour was evaluated using a ball-on-disc method. Corrosion properties were estimated on electrochemical tests, such as potentiodynamic polarisation. The results demonstrated an enhancement in the density and porosity of the composites as the sintering temperature increased. A uniform dispersion of ZrB2 was observed in the copper matrix for all composites. With an increase in the content of the ZrB2 reinforcement phase, there was an increase in microhardness and an improvement in the wear resistance of the sintered composites. A reduction in densification and corrosion resistance of Cu-based composites was observed with increasing ZrB2 content.
Iron Homeostasis-Related Parameters and Hepcidin/Ferritin Ratio: Emerging Sex-Specific Predictive Markers for Metabolic Syndrome
Authors: Abu AlSel Baraah T. , Mahmoud Abdelrahman A. , Hamed Elham O. , Hakim Noor A. , Sindi Abdulmajeed A. A. , Jawad Najlaa M. M. , Gusti Amani M. T. , Fawzy Manal S. , Abd El-Fadeal Noha M.
Published: August 2024

Metabolic syndrome (MetS) is a worldwide public health challenge. Accumulating evidence implicates elevated serum ferritin and disruptions in iron metabolism as potential elements linked to an increased risk of MetS. This study investigates the relationship between iron homeostasis—including hepcidin levels, serum iron concentration, unsaturated iron-binding capacity (UIBC), and the hepcidin/ferritin (H/F) ratio—and MetS. In this descriptive cross-sectional study, 209 participants aged 24–70 were categorized into two groups: 103 with MetS and 106 without MetS. All participants underwent medical assessment, including anthropometric measures, indices of glycemic control, lipid profiles, and iron-related parameters. Participants were further stratified by the Homeostasis Model Assessment—Insulin Resistance index into three subgroups: insulin-sensitive (IS) (<1.9), early insulin resistance (EIR) (>1.9 to <2.9), and significant insulin resistance (SIR) (>2.9). Notable increments in serum ferritin and hepcidin were observed in the SIR group relative to the IS and EIR groups, with a significant association between metabolic parameters. The UIBC and serum ferritin emerged as significant predictors of MetS, particularly in men, with an area under the curve (AUC) of 0.753 and 0.792, respectively (p ≤ 0.001). In contrast, hepcidin was notably correlated with MetS in women, with an AUC of 0.655 (p = 0.007). The H/F ratio showed superior predictive capability for MetS across both sexes (at cutoff level = 0.67). Among women, this ratio had an AUC of 0.639 (p = 0.015), and for men, it had an AUC of 0.792 (p < 0.001). Hypertension proved an independent risk factor for MetS, affirming its role in metabolic dysregulation. The findings highlight a significant interconnection between iron homeostasis parameters and MetS, with sex-specific variations underscoring the importance of personalized diagnostic criteria. The crucial role of the H/F ratio and the UIBC as emerging predictive markers for MetS indicates their potential utility in identifying at-risk individuals. Further longitudinal research is essential to establish causality and explore the interplay between these biomarkers and MetS.