bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical utility of MODAPTS during work assessment: Perceptions of South African occupational therapists
Authors: Buys Tania Lee , Harmse Suzanne , Slawson Caitlin Christina , Rapolai Boitumelo Thamirah , Rapotu Kwena Dorah , Furniss Sian Gabrielle , Jacobs Karma
Published: April 2024

Introduction:

Clinical utility is an important attribute in selecting an assessment tool. The study aimed to determine the perceptions of South African occupational therapists of the clinical utility of Modular Arrangement of Predetermined Time Standards (MODAPTS) work samples when assessing a client’s work ability. The research objectives were to determine whether MODAPTS is perceived to be credible, practical, useful, and easy to use.

Methodology: A quantitative, cross-sectional, descriptive research design was used. Non-probability sampling with elements of voluntary response- and snowball sampling was used to recruit respondents. An electronic questionnaire was developed using Qualtrics, which was distributed electronically via the Occupational Therapy Association of South Africa, WhatsApp and Telegram.

Results: Data were based on 52 completed questionnaires, analysed through descriptive statistics. MODAPTS was perceived as practical, useful, credible, and asy to use in practice. Main barriers to the use of MODAPTS included the timeliness of developing work samples, lack of MODAPTS training, and having other more useful and reliable assessment tools. Experienced occupational therapists used MODAPTS more often than inexperienced occupational therapists.

Conclusion: Clinical utility of work samples developed using MODAPTS has been confirmed. This supports the use of work samples developed using MODAPTS as part of work assessments as a cost-effective, practical tool.

Implications for Practice:

•Development of contextually relevant work samples.

•Use of MODAPTS work samples as an outcome measure during intervention.

•Application during rehabilitation goal setting •Cost effective application of MODAPTS work samples in a variety of settings
Identifying key inflammatory genes in psoriasis via weighted gene co-expression network analysis: Potential targets for therapy
Authors: Li Huidan , Wang Xiaorui , Zhu Jing , Yang Bingzhe , Lou Jiatao
Published: April 2024

Psoriasis is a globally prevalent chronic inflammatory skin disease. This study aimed to scrutinize the hub genes related to inflammation and potential molecular mechanisms in psoriasis. Utilizing mRNA expression profiles from public datasets GSE13355, GSE78097, and GSE14905, we set up a comprehensive analysis. Initially, we selected differentially expressed genes (DEGs) from psoriasis and control samples in GSE13355, followed by calculating inflammatory indices using genomic set variation analysis (GSVA). Weighted gene co-expression network analysis (WGCNA) was then applied to link significant modules with the inflammatory index. This process helped us identify differentially expressed inflammation-related genes (DE-IRGs). A protein-protein interaction (PPI) network was established, with the molecular complex detection (MCODE) plug-in pinpointing six chemokine genes (CCR7, CCL2, CCL19, CXCL8, CXCL1, and CXCL2) as central hub genes. These genes demonstrated pronounced immunohistochemical staining in psoriatic tissues compared to normal skin. Notably, the CCR7 gene exhibited the highest potential for m6A modification sites. Furthermore, we constructed transcription factor-microRNA-mRNA networks, identifying 139 microRNAs and 52 transcription factors associated with the hub genes. For the LASSO logistic regression model, the area under the curve (AUC) in the training set was 1, and in the two validation cohorts GSE78097 and GSE14905 were 1 and 0.872, respectively. In conclusion, our study highlights six chemokine genes (CCR7, CCL2, CCL19, CXCL8, CXCL1, and CXCL2) as potential biomarkers in psoriasis, providing insights into the immune and inflammatory responses as pivotal instances in disease pathogenesis. These findings pave the way for exploring new therapeutic targets, particularly focusing on chemokine-associated pathways in psoriasis treatment.
Nitrogenated Fertilization In Pasture Brachiaria Brizantha Cv. Marandu Via Organic Compounds
Authors: Soares G. R. , Tavares V. B. , Neiva Júnior A. P. , Fernandes L. O.
Published: April 2024

The objective was to evaluate the quantitative and qualitative effect of fertilization of Brachiaria brizantha cv. Marandu using nitrogen from liquid cattle manure and organomineral fertilizer. The experiment was developed in a pasture already established and soil analysis of this area was made for the necessary corrections. The experimental design was randomized blocks in a 4 x 2 factorial scheme. The treatments consisted of control with 0 kg/ha of N, 3 treatments with application of bovine liquid manure and 3 treatments with organomineral fertilizer in the dosages of 60, 120 and 180 kg/ha of N. Three cuts were made in Marandu grass when the pasture reached 30 cm in height, leaving a residue of 15 cm, the production of DM, leaf production, stem, CP, NDF and ADF were evaluated. At the end of the experiment, the cost of fertilizing with manure and organomineral fertilizer was done. To compare the averages obtained and the morphological components of each sample, the Tukey test at 5% significance was used, with the aid of the SISVAR statistical program. With the highest nitrogen levels of organomineral fertilizer and the bovine liquid manure, a higher CP content was obtained, reaching 9.30; 7.78 and 7.90% in the first cut, with organo 180, 120 and manure 180 respectively. Fertilizations with manure 60 and 180, organomineral 120 and 180 showed the lowest values for NDF in the first cut, the ADF only showed a significant difference in the second cut with organo 60, manure 120 and 60 with the highest values. Organomineral fertilizer in different doses provided higher production, but at a higher cost. Fertilization improved the quality of the forage.
Mechanisms of sexual dimorphism in the pathogenesis of sarcomas
Authors: Belitsky G. A. , Fetisov T. I. , Shtompel P. A. , Lesovaya E. A. , Bokhyan B. Yu. , Yakubovskaya M. G. , Kirsanov K. I.
Published: April 2024

Sarcomas of non-genital organs affect women 1.5–3 times less often than men. The mechanism of such dimorphism is studied at various levels, mainly in the field of influence on the pathogenesis of sex hormones and their receptors, the effect of which is significantly related to the histogenesis of the tumor, its localization, the mechanism of malignant transformation and the stage of progression. Sex hormone receptors are often found in the early stages of tumor development and are lost during progression. At the same time, the expression of the same receptors in tumors of different histogenesis sometimes correlates with the opposite prognosis of the disease and sensitivity to hormonal therapy. For example, in uterine leiomyosarcomas, the expression of estrogen and androgen receptors correlates with a better prognosis and greater effectiveness of therapy, and in osteo- and fibrosarcomas, vice versa. Estrogens stimulate proliferation of osteosarcoma cells, and androgens that of rhabdomyosarcoma and small round cell tumor, which growth is inhibited by antiandrogens used in the treatment of prostate cancer. In this regard, when trying to include a hormonal component in a therapeutic complex, an individual study of the hormonal sensitivity of the tumor is necessary. One of the methodological approaches to this could be testing a culture of tumor cells from surgical material for sensitivity to agonists/antagonists of hormonal receptors separately and in combination with chemotherapy drugs.
Components of the microenvironment of soft tissue sarcomas. Part I
Authors: Lokhonina A. V. , Jumaniyazova E. D. , Dzhalilova D. Sh. , Kosyreva A. M. , Kazaryan G. G. , Fatkhudinov T. Kh.
Published: April 2024

Soft tissue sarcomas (STS) are a rare heterogeneous group of malignant neoplasms characterized by aggressive course and poor response to treatment. This determines the relevance of research aimed at studying the pathogenesis of STS. The tumor microenvironment consists of stromal, immune cells, blood, lymphatic vessels, and extracellular matrix. By now, it is known that STS is characterized by complex relationships between tumor cells and components of the microenvironment. Dynamic interactions between tumor cells and components of the microenvironment enhance adaptation to changing environmental conditions, which provides high aggressive potential of STS and resistance to antitumor therapy. Basic research aimed at investigating the role of microenvironmental components in STS carcinogenesis may serve as a key to the discovery of both new prognostic predictor biomarkers and targets for new antitumor drugs. This review article is devoted to the role and interaction of STS cells with components of the microenvironment.
Paraneoplastic dermatosis in pediatric and adult patients
Authors: Murashkin N. N. , Valiev T. T. , Belysheva T. S. , Ivanov R. A. , Sofronov D. I. , Ryabukhina Yu. E. , Savelyeva M. I. , Zeynalova P. A.
Published: April 2024

Clinical, morpho-immunological and cytogenetic characteristics of malignancies are very polymorphic. And no less heterogeneous are paraneoplastic skin presentations arising before malignant tumour manifestation and/or proceeding in parallel. In the current literature review the most common paraneoplastic dermatosis are presented: pyoderma gangrenosa, dermatomyositis, paraneoplastic pemphigus, pityriasis rubra pilaris, Bazex syndrome, necrolytic migratory erythema, ptyriasis rotunda, Sweet syndrome. It is provided modern concepts in pathogenesis, clinical features and treatment approaches.
Rehabilitation of cancer patients: the use of pneumatic compression in secondary lymphedema treatment
Authors: Ivashkov V. Yu. , Rovnaya A. V. , Denisenko A. S. , Kolsanov A. V. , Nikolaenko A. N.
Published: April 2024

Complex decongestive therapy is a cornerstone of conservative chronic lymphedema treatment. There are other conservative treatment options that include intermittent pneumatic compression. Its mechanism of action is based on pressure applying on the underlying tissues and promoting the lymph flow through the lymphatic structures. Pneumatic compression was invented in 1972; nevertheless it has not found widespread support of professional community as a self-sufficient method of conservative lymphedema treatment, though it’s used a lot in many rehab clinics worldwide.

Aim. To determine the indications and effectiveness of pneumatic compression, as well as to identify the possibility of using this method in the practice of treating lymphatic edema.
The Importance of the Structure of Federal Executive Authorities in Public Administration
Authors: Rossinskiy B. V.
Published: April 2024

The paper shows that the current system of federal executive authorities, being an abstract category, is implemented only through the functioning of a specific structure of these bodies. As a set of real subjects, this structure materializes the management strategy embedded in the system of federal executive authorities, which, however, does not arise chaotically, but is formed in the process of development of the system of bodies and their corresponding structure. The paper examines the dynamics of the system and structure of the central executive bodies in the USSR and federal executive authorities in the Russian Federation. The author has analyzed the advantages and disadvantages of corresponding systems and structures that existed in post-Soviet Russia before 2004, as well as structures functioning currently. The information problems of the modern model of federal executive bodies, types and features of communication channels peculiar to the system under consideration have been analyzed. It is argued that the nature of information links between the elements of the system structure determines the degree of stability of the structure itself and, as a result, the entire mechanism of public administration, i.e., the probability of their preservation or destruction. It is concluded that the importance of the structure of federal executive authorities is explained not only in optimizing management activities, but also in forming such a configuration of information communication channels in a specific system of executive bodies that stabilizes the functioning of the entire mechanism of public administration.
Informational Determinants of Violence Against Person and the Preventive Function of Law
Authors: Sergeev P. V.
Published: April 2024

The paper analyzes the problems of legal regulation of the circulation of information justifying violence against person. The urgency of the problem and the need to resolve it as a matter of priority are substantiated. Special attention is paid to the conceptual apparatus used by the legislator and issues of responsibility. There is an unjustified variety of terms contained in relevant normative legal acts («appeals», «propaganda», «justification», «advocating», «incitement»), as well as the lack of a uniform understanding of violence in law enforcement practice. The author critically analyzes the sociocentrism of the legislator’s approach to responsibility for the propaganda of violence, as a result of which the security of the individual seems to the law enforcement officer to be less significant in comparison with the security of a social group. The author compares domestic and foreign regulation of the considered sphere of public relations. The conclusion is made about the need for a systematic approach to solve the problem, inter-sectoral improvement of Russian legislation. Such improvement should result in recognition of the propaganda of violence against person as no less dangerous than the propaganda of politically, ideologically and religiously motivated violence.
Genomic Research and Artificial Intelligence: Problems of Legal Regulation at the Global and Regional Level
Authors: Ponomareva D. V. , Nekoteneva M. V.
Published: April 2024

The authors examine the trends and features of the development of legal regulation of genomic research in the context of digitalization at the level of global and regional international organizations, including integration associations. The current sources of legal regulation of the use of artificial intelligence technologies in the field of genomic research in modern international and integration law are analyzed, and the main trends in the development of global and regional regulation are identified. Attention is given to the fact that key international acts adopted both at the global and regional levels, and regulating certain aspects of genomic research, are so-called acts of soft law, which are advisory and constitute a kind of «pre-law». In conclusion, recommendations are presented for improving the relevant legal regulation within the framework of integration associations with the participation of the Russian Federation.
Civil Society as in the Constitutions of Foreign Countries
Authors: Bagiryan G. A.
Published: April 2024

Due to various circumstances, not every scientist recognizes the need for constitutional and legal regulation of the foundations of civil society. Some researchers argue their position by the fact that such regulation has not become widespread in the constitutional acts of countries with developed democracies. At the same time, in one form or another, certain aspects of civil society are found in the constitutions of foreign countries, which differ from each other in the way of organizing state power, and in the form of government, and in the regime of government. The paper provides an analysis of individual provisions of the constitutions of foreign countries from different regions of the world regarding the formal consolidation of the term «civil society», as well as the existence of constitutional and legal regulation of the foundations of civil society. An analysis of the constitutions of foreign countries made it possible to identify general patterns of disclosure at the constitutional and legal level of certain aspects that were traced in the provisions of the constitutions and directly related to civil society and its individual institutions.
Tumor-infiltrating lymphocytes: opportunities to use their potential in clinical practice in breast cancer
Authors: Mnikhovich Maxim V. , Erofeeva Lyudmila M. , Borisov Denis A. , Timofeev Roman G. , Agafonova Yulia S. , Bezuglova Tatyana V. , Shiripenko Ivan A.
Published: April 2024

Tumor-infiltrating lymphocytes are currently considered as a prognostic biomarker of cancer patient survival and response to therapy, as well as a target for immunotherapy. However, tumor-infiltrating lymphocytes are only part of the tumor microenvironment, which consists of cellular and cytokine components. The cellular component also includes tumor-associated macrophages, neutrophils, fibroblasts and other cells. The cytokine component is represented by the products of the activity of all cells of the microenvironment, as well as tumor cells.
This review examines various subpopulations of tumor-infiltrating lymphocytes, shows their interaction with tumor cells and other cell populations of the tumor microenvironment, and also describes the potential for clinical use of this cell population as a biomarker for predicting clinical outcomes and the possibility of their use to determine the most effective treatment for breast cancer.
Obtaining new data on the previously poorly studied components of the tumor microenvironment and tumor-infiltrating lymphocytes, as well as the formation of ideas about the mutual influence of tumor microenvironment cells and tumor cells open up the prospect of developing innovative models of therapy. One of the modern directions is the search for molecular mechanisms of maintaining the antitumor activity of tumor-infiltrating lymphocytes, as well as the polarization of cells in the tumor microenvironment. Advances in the field of molecular oncology will make it possible to reduce the mortality rate of cancer patients to minimal levels while maintaining or even improving their standard of living.
Ethyl alcohol: Influence on the dynamics of blood supply of skin and other soft tissues during their sudden cooling
Authors: Urakov A. L.
Published: April 2024

In the norm (i.e., the absence of ethyl alcohol in blood in sober people), sudden local cooling of the skin and soft tissues of different parts of the body from +37°С to +18°С and below (but not below 0°С) causes two-phase changes in blood vessels tone, blood filling, and intensity of blood supply and pain in the cooled tissues. In the first seconds of cooling, the tone of the muscular blood vessels begins to increase and their blood filling decreases, the skin color lightens, and in the cooled area of the body, acute soreness develops. After a few tens of seconds of cooling, spasm in the blood vessels reaches maximum level and their filling with blood decreases to a minimum, the skin turns white, and the soreness becomes severe. These changes persist at their peak for a few minutes, after which they begin to disappear, despite the persisting hypothermia. However, after 10–15 minutes of cooling, hyperemia develops in the hypothermia zone; as a result, the soreness disappears and the skin reddens. Notably, in the norm, sudden cooling of tissues causes irritation of the temperature receptors found in them. The resulting excitation of temperature receptors causes reflex spasm of blood vessels, which has an adaptive value, as it developed for temperature homeostasis of warm-blooded organisms. Acute pain accompanying cold spasm of blood vessels has been found to be due to mechanical squeezing of pain receptors located under the muscular layer in the wall of blood vessels. Conversely, the presence of ethyl alcohol in the blood or, in severe cases, alcohol intoxication changes the dynamics of blood supply in tissues at their sudden cooling: during cooling, blood vessels expand and overflow with blood without the initial phase of spasm and occurrence of pain. Moreover, hyperemia persists throughout and after the cooling period. That is, alcohol intoxication is manifested by the immediate development of hyperemia and skin redness in the cooled area of the body without the initial spasm of blood vessels and appearance of soreness and pallor of the skin in the area of cooling.
Morphological changes in the hippocampus of the rat brain in ischemia and in conditions of combined preconditioning
Authors: Novikov V. E. , Levchenkova O. S. , Korneva J. S.
Published: April 2024

BACKGROUND:Preconditioning is effective for increasing the body’s resistance to hypoxia/ischemia. AIM: To evaluate morphological changes in the most hypoxia-sensitive fields of the hippocampus CA1 and CA3 in cerebral ischemia in rats and under conditions of combined preconditioning.MATERIALS AND METHODS:Cerebral ischemia was simulated in rats under anesthesia (8% chloral hydrate solution, 400 mg/kg) by bilateral ligation of the common carotid arteries. The combined preconditioning method included the alternate use of two preconditional factors: pharmacological (amtisol, 25 mg/kg) and hypoxic (hypobaric hypoxia, 410 mmHg; exposure time, 60 min). Morphometric assessment of brain damage was performed a day after modeling ischemia in the CA1 and CA3 fields of the hippocampus. RESULTS: Combined preconditioning has a positive effect on the morphometric parameters of the brain during ischemia, including increasing neuronal survival in the early and late periods of ischemia modeling, preventing the formation of necrotically and apoptotically altered neurons, hyperactivation of microglial cells, and contributing to endotheliocyte preservation.CONCLUSIONS:Combined preconditioning (amtisol + hypobaric hypoxia) has a neuroprotective effect in cerebral ischemia.
3D Geometry and Slip Distribution in the Long Beach Earthquake Gate, Newport–Inglewood Fault, Los Angeles, California
Authors: Toghramadjian Natasha , Shaw John H.
Published: April 2024

We present a new, 3D representation of the Long Beach restraining bend system along the Newport–Inglewood fault (NIF), Los Angeles, California. The NIF is an active strike-slip system that cuts over 60 km through densely populated metropolitan Los Angeles and poses one of the greatest deterministic seismic hazards in the United States (California Division of Mines and Geology, 1988). Part of the NIF sourced the 1933 M 6.4 Long Beach earthquake, which claimed ∼120 lives and remains one of the deadliest events in California history (Barrows, 1974; Hauksson and Gross, 1991). The event is thought to have arrested at Signal Hill within the Long Beach restraining bend, which is formed by a left step in the NIF (Hough and Graves, 2020). Events that rupture through Signal Hill could generate larger (M ≈7) events that pose a significant hazard to urban Los Angeles. Our analysis integrates a diverse range of datasets, including over 4200 fault and horizon penetrations from 243 wells, 2D seismic reflection surveys, field maps, machine-learning-based tomography studies, and the U.S. Geological Survey QFaults surface traces. We show that the fault system in Long Beach has three main strike-slip segments connected by orthogonal reverse faults. The strike-slip faults are nonvertical and nonplanar, merge at depth, and extend through the seismogenic crust. The Long Beach restraining bend system presents numerous rupture pathways and arrest points that NIF earthquakes may follow. We apply a novel, map-based restoration to quantify how much total slip has passed through each of the fault segments. About 375 m of total slip is partitioned into the three main fault strands, including the Reservoir Hill fault (≈75 m), the Northeast Flank fault (≈120 m), and the Cherry Hill fault (≈209 m). This slip partitioning informs our understanding of the tendency of ruptures to involve different fault segments or arrest at specific junctures.
The Beginnings of the Process of Separating the Attorney-at-Law Profession in the First Decade of the Polish People’s Republic
Authors: Niewiński Kamil
Published: April 2024

The roots of the attorney-at-law profession are seen in the 16th-century professions of syndicates and instigators. The attorney-at-law posts appeared in Poland in the 19th century. These posts were occupied mainly by advocates. Attorney-at-law, as a new legal profession, began to separate from the advocacy after World War II, during the period of the Polish People’s Republic. It was facilitated by the introduced model of a centrally controlled socialized economy. The process of separating the attorney-at-law profession was long. The full legal separation took place in the 1980s. However, the phenomenon of the professional distinctiveness and identity of attorneys-at-law emerged in the 1950s. The article focuses on the beginnings of the process of separating the attorney-at-law profession and indicates the key factors that led to this.
Cross-Border Functional Area as an Organisational and Legal Instrument of Polish-Lithuanian Cross-Border Cooperation
Authors: Studzieniecki Tomasz , Jakubowski Andrzej , Kurowska-Pysz Joanna
Published: April 2024

The development of cross-border cooperation in the European Union requires the refinement of organisational and legal instruments which support the cooperation of the local and regional authorities in neighbouring border regions. One such instrument may be the Cross-Border Functional Area (CFA). The authors of the article were in charge of the implementation of a pioneering project commissioned by Directorate-General for Regional and Urban Policy (European Commission) to establish the first CFA in Europe in the Polish-Lithuanian border region. It was formed by nine cities and communes (Pol. gmina) from Sejny and Suwałki counties and three Lithuanian local authorities: Lazdijai, Vilkaviškis and Kalvarija. The main objective of the article is to identify the qualities of a CFA as an organisational and legal instrument supporting the development of cross-border cooperation. An additional objective is to identify the key organisational and legal determinants of the development of the CFA in the Polish-Lithuanian border region. The article has a scientific and research character. It characterises CFAs in relation to other forms of institutional cross-border cooperation, discusses the legal basis for the establishment of a CFA, presents the organisational structure and identifies the key stakeholders. The lack of a legal definition of a CFA makes its use difficult, but not impossible. The importance of functional connections in cross-border cooperation in the EU is sufficiently significant to warrant further research on the institutionalisation of cooperation within cross-border functional areas.
Nationalism as a Manipulation of Collective Imaginaries (Stereotypes) of One’s Own and Strangers in Jan Stanisław Bystroń’s “National Megalomania”
Authors: Baranowska Marta`
Published: April 2024

The research purpose of the article is to analyse Jan Stanisław Bystroń’s research on collective imaginaries of one’s own people and strangers, on the basis of which he formulated an original perspective on the perception of nationalism. The research question is as follows: What is nationalism in the views of Bystroń? He was one of the first scholars to point out that nationalism boils down to the manipulation of collective imaginaries that are the source of prejudice. His National Megalomania (1924) can be considered a forerunner of research on stereotypes. The research purpose of the article is also to point out that his comments on national megalomania preceded the theories on collective narcissism formulated in the 1970s by Erich Fromm and Theodor W. Adorno. They are to this day analysed in scholarly literature, also in the context of research on nationalism. These analyses indicate that the source of narcissism is ressentiment. This concept of Friedrich Nietzsche is also used in theories about nationalism, so it was also included in the analysis of nationalism in this article. Bystroń’s research was interdisciplinary in nature, which allowed him to point out a new and, in many points, pioneering perspective on the perception of nationalism. Research on his work also requires an interdisciplinary approach. For this reason, the study uses references to theories from a wide spectrum of social and humanistic research. As a result, it was possible to interpret Bystroń’s contribution to the study of nationalisms from a broader perspective.
Image of the Community of Legal Professionals in the Television Coverage – a Case Study
Authors: Stefaniuk Małgorzata E.
Published: April 2024

The aim of the study, which is of a scientific and research nature, is to present the mass media image of the community of legal professionals in Poland. It is a case study based on a specific television coverage in the form of a pseudo-documentary series titled Caste (Pol. Kasta) broadcast by Polish public television. This image is important for the correct organisation of social relations. The significance of the issue and the way it is presented deserve a closer insight, especially since lawyers have not been in high positions in public opinion polls on the prestige of professions for years. The pseudo-documentary was chosen as the research material for the study, because it falls within the broader concept of a documentary while being a certain novelty. For the purpose of the study, a test sample was selected. As a result of the research, it has been shown that the picture of the community of legal professionals presented in pseudo-documentary TV shows in Poland is negative. The usual plot of such shows is that as a result of various kinds of informal deals, unfair decisions are made which are harmful for the victims of the deal, for which the entirety of legal community is blamed, including primarily judges. Exceptions are very rare, and the only hope are young, idealist advocates who are presented as lawyer role models. The TV show Caste, operating unfair simplifications and stereotypes, was part of a series of actions aimed at discrediting the legal community in Poland and did not improve its image. The balance between facts and fiction has been disturbed, which served to support a presupposition that Polish realities are flawed due to the conduct of legal professionals, especially judges. Only those problems in the judiciary have been emphasised, which have helped to prove the need for reform, particularly corruption. Educational opportunities typical of this form of communication were not used, hence the level of legal awareness of Polish society was not raised. It can be hypothesized that the presented image from a medium that constitutes the main source of information and has the largest audience, could have affected the opinion about legal practitioners in Polish society. The TV series met a response from the public, which however requires a separate study.
Greek and Macedonian Political Refugees in the Polish People’s Republic and the Current Migration Crisis on the Polish-Belarusian Border
Authors: Citkowska-Kimla Anna , Kimla Piotr
Published: April 2024

The aim of the article is to conduct a comparative analysis of two different approaches to the migration problem. The first one refers to the government of the Polish People’s Republic, which agreed to accept several thousand Greek and Macedonian political refugees fleeing from Greece after the communist side lost the civil war. The policy of the Polish communist authorities brought success in the form of successful coexistence between Greeks and Macedonians with Poles. The second approach is presented by the current Polish government. This is a policy of not admitting any migrants brought to the Polish-Belarusian border by the Belarusian and Russian regimes that are hostile to Poland. The presented comparison is an original attempt to draw conclusions regarding the sources of these different approaches and their political and social consequences. The topic discussed in the article is important not only for Poland and the eastern countries of the European Union, but for the entire EU, because the destination of migrants is not countries such as Poland, Lithuania or Latvia, but wealthier Western countries.
Síndrome de DRESS inducido por minociclina en paciente de 15 años. Reporte de caso
Authors: Rodriguez Cruz Ericka Carolina , Alas Pineda Cesar Ulises , Oliva Caceres Liliana Maria , Izaguirre Peralta Julio Cesar , Mass Cruz Angie Gimena
Published: April 2024

ANTECEDENTES: El Síndrome de Reacción a Drogas con Eosinofilia y Síntomas Sistémicos(DRESS) es una reacción adversa a medicamentos, potencialmente mortal enun 10% de los casos.CASO CLÍNICO: Paciente masculino de 15 años que acude a la emergencia de pediatríacon historia clínica de exantema morbiliforme y pruriginoso en cara y cuellode 9 días de evolución, extendiéndose a tórax y extremidades, acompañado de fiebrede 38,0°C de 1 día de evolución. Paciente con antecedentes patológicos de atopia yacné vulgar, tratado con minociclina. Al ingreso el hemograma reportó leucocitos de16,900 células/ml, eosinófilos 18.2%, neutrófilos 6.2%. La química sanguínea reveló:creatinina de 1.92 mg/dl, TSGO de 45 U/L, TSGP 287 U/L, PCR: 62.8 mg/L y VES de21 mm/h. Se decidió su ingreso a unidad de cuidados intensivos pediátricos, ya quecumplió con 7 puntos de RegiSCAR.CONCLUSIÓN: El síndrome de DRESS es una reacción severa y potencialmente mortal,su diagnóstico es un reto por su heterogeneidad y variabilidad clínica. Debe tomarseen consideración luego de un interrogatorio detallado que arroje el uso de fármacossospechosos previo al inicio de la sintomatología, aunque que su incidencia no estádel todo descrita.
Los Trastornos de conducta o TDA-H ¿Sobrediagnosticamos?
Authors: Garamendi Eduardo Espinosa , Labra Ruiz Norma Angélica , Santos González Luis Antonio
Published: April 2024

Distinguir lo normal de lo patológico en psicopatología infantil es muy complejo ya que en el paciente pediátrico, debe tenerse en cuenta el nuerodesarollo constante y cambiante. Las clasificaciones nosológicas (CIE-11 y DSM-5) ubican al Trastorno de Déficit de Atención (TDAH) y a los Trastornos de Conducta/Trastornos de Conducta Desafiante (TC/TCD) dentro de los trastornos del neurodesarrollo. Debido a que  los síntomas pueden traslaparse entre sí, es necesario ser precavidos en el diagnóstico inicial. TDAH es el trastorno neuropsiquiátrico más frecuente de la infancia, con un patrón neurobiológico persistente de inatención acompañado de hiperactividad y/o impulsividad inadecuado en el desarrollo social, académico e incluso ocupacional del paciente. Los TC se manifiestan principalmente en el ámbito familiar y son frecuentes, aunque no específicos, de la adolescencia. No existen biomarcadores por lo que el análisis de la conducta y las herramientas neuropsicológicas, son fundamentales para su diagnóstico.
Provisión de cuidados humanizados en unidades de cuidados intensivos neonatales
Authors: Raygadas Rivera Luis Alberto
Published: April 2024

Los Cuidados Humanizados y Cuidados Centrados en la Familia proveen atención holística considerando los factores familiares, físicos, sociales y espirituales del neonato y su familia. Este artículo tiene como objetivo revisar los desarrollos y estado actual de los Cuidados Humanizados y Cuidados Centrados en la Familia en la Unidad de Cuidados Intensivos Neonatales, siguiendo las 7 líneas de trabajo para la Humanización de los Cuidados y lograr beneficios sobre todos los factores considerados.
Mesas ejecutivas sur-sureste de industrias culturales y creativas: un espacio permanente de coordinación interinstitucional de las industrias culturales y creativas del sur-sureste de México
Authors: Luzardo Alejandra , Majlis Martina , Rebolledo Nicolás , López Valentina , Revuelta Zabel , Majlis Signorio Martina
Published: April 2024

Durante el año 2023, el Banco Interamericano de Desarrollo (BID) implementó mesas ejecutivas de trabajo interinstitucionales y permanentes en tres estados del Sur-Sureste de México: Yucatán, Chiapas y Oaxaca. Este esfuerzo se centró en destrabar los cuellos de botellas que limitan el crecimiento del sector cultural y creativo en la región. Esta publicación presenta de manera concisa la metodología replicable diseñada por el BID para llevar a cabo el proyecto, así como su impacto, lecciones aprendidas y recomendaciones resultantes de esta iniciativa.
Evaluación probabilística y económica de dos diseños de mezclas de hormigón ligero en la resistencia mecánica de mampuestos alivianados con fibras de PET triturado
Authors: Bernal Jiménez Kevin Rafael , Calvache Cruz Wladimir A. , Santamaría Carrera Jorge L.
Published: April 2024

El presente artículo tiene como objetivo evaluar dos metodologías de dosificación para elaborar bloques de alivianamiento con material reciclado de envases PET triturados cumpliendo con la normativa vigente NTE INEN 3066. La evaluación se realizó por medio de análisis estadísticos y financieros en donde se identificó el diseño de mezcla más óptimo referente a sus propiedades mecánicas, como costos de fabricación respectivamente. La metodología consistió en dosificar al peso, reemplazando el material fino (cascajo) en un 50 % por el material plástico. Los dos diseños de mezclas utilizados fueron la ACI 211.2 (denominada mezcla 1) y una modificación de esta norma americana adaptada a las propiedades específicas de los materiales disponibles en Ecuador (denominada mezcla 2). La resistencia se evaluó al someter una tanda de 20 mampuestos a compresión simple con la ayuda de la máquina universal; además, de los resultados obtenidos de cada tanda, se determinó el control de calidad a partir de un análisis estadístico de distribución de campana de Gauss. El costo unitario se analizó empíricamente a partir del rendimiento existente durante cada una de las fases de fabricación del bloque. Con los resultados obtenidos se observó una correlación entre la resistencia a compresión simple junto al rendimiento y el costo de producción unitario del bloque; determinando la mezcla 2 como la más óptima al alcanzar una resistencia promedio de 3,60 MPa con un menor rendimiento de 0,014 y un menor costo por bloque de 0,57 centavos. Esto demuestra que la segunda metodología resulta la mejor opción para elaborar bloques tipo C cumpliendo con los criterios de la norma ecuatoriana NTE INEN 3066, pero considerando un costo de producción superior al bloque artesanal. Finalmente, los resultados obtenidos no solo son valiosos para la optimización del proceso de fabricación de bloques, sino que sugieren nuevas soluciones sostenibles en la construcción y destacan la importancia de los estándares normativos y la viabilidad económica.
MODERN ONLINE CONSTRUCTORS OF CROSS-MEDIA STORIES: VARIETIES, TOOLS AND APPLICATION FEATURES
Authors: Azieiev Serhii , Orlova Olena
Published: April 2024

The phenomenon of storytelling is not new in the global information environment, but it has significantly evolved in the era of digital transformation. Moreover, the rapid development of network technologies, alongside the total digitization of society, has transformed storytelling into a unique media formation with a powerful synergistic effect achieved through the merger of cross-media components.
This study focuses on the toolkit of modern storytelling, particularly on online resources for creating cross-media stories. Various types of such constructors are considered, specifically in the context of the functioning of the Ukrainian media sphere.
The features of using certain popular multifunctional online storytelling tools are described in a journalistic dimension, to create such cross-media products as longreads, multimedia texts, and more.
The level of presence of the issue of constructing cross-media stories in the research field of contemporary scholars is reflected.
PROBLEMS OF MEDIA FINANCING DURING WAR AND WAYS TO SOLVE THEM
Authors: Miroshnychenko Viktoriia
Published: April 2024

The article is devoted to the issue of financing the media industry during crises and wars. The main difficulties faced by the Ukrainian mass media after the beginning of the full-scale invasion of the Russian Federation into the territory of Ukraine are studied. Analyzing the financial instruments used for the survival and development of the media.
We all understand that the media is not only a source of information space, but also one of the sectors of the state’s economy. Therefore, as we turn the page of the second year of the full-scale invasion of Ukraine by the Russian Federation, we cannot but address the question: “What financial difficulties did our media face during the war, how did they overcome them, and what are the possible sources of funding now?” That is, to look into the eternal question “Where to get money?” and how can media enterprises survive in times of crisis?
Unfortunately, the problem of media funding during the full-scale invasion of Ukraine by the Russian Federation has not yet been sufficiently addressed in scientific research. However, due to the extreme relevance of this problem, it was primarily addressed by journalists themselves, raising it at journalistic forums and in their materials.
The purpose of the article is to outline the problem of media financing during the war and the ways to solve it that are used by Ukrainian media in everyday life. To achieve this goal, it is necessary to consider changes in grant support for the media, analyze support from volunteer “donors”, consider the possibility of contracts with local authorities for coverage as a source of funding, consider potential opportunities for paying for content, analyze state support for Ukrainian media, and more.
Thus, the loss of 90% of the advertising market at the beginning of the invasion, the departure of some journalists abroad, the inability to fulfill their financial obligations, the loss of offices and many other disappointments did not stop active, dedicated professionals in their desire to create! And tools, especially those such as finance, are always available when you have a great desire and a dream. Since Ukrainian journalism has been addressing the issue of alternative financing for two years, the field for further research is almost unlimited, and many economic experts are just now beginning to delve into this issue.
UKRAINIAN IDENTITY IN THE CONTEXT OF RUSSIA'S HYBRID WAR AGAINST UKRAINE. KHERSON
Authors: Petrova Nataliia , Rudus Iryna
Published: April 2024

The article is devoted to the study of the preservation of Ukrainian identity in the context of Russia's hybrid war against Ukraine. The study of this topic is extremely relevant to us, especially in times of war. After all, the preservation of national heritage plays a huge role in establishing Ukraine as a free, independent state. Cultural heritage is one of the main factors in the formation of Ukrainian identity and the revival of the spirituality of the Ukrainian people. Under occupation, the threat of losing cultural identity is growing. Therefore, one of the most relevant areas of research is the study of the experience of preserving national consciousness under occupation. One such example is the liberated Kherson. It was during the occupation that Kherson residents fought for their cultural identity. Thanks to modern digital technologies, they resisted Russian culture and the narratives spread by Russia so powerfully. This study examines a narrowly focused example of Ukrainians preserving their national identity under occupation, using Kherson as a case study.
The aim of this article is to identify the markers of Ukrainian identity and trace them in the conditions of war.
ROMANIAN ARCHITECTS IN ODESSA (1941-1944) AND THEIR SUBSEQUENT FATE
Authors: Mitric-Ciupe Vlad
Published: April 2024

The topic of Holocaust is mostly mentioned in reference to Transnistria in the years of 1941-1944. Our research studies concerning the rapport between the officials and the architects/architecture during the totalitarian regimes in Romania unveiled the opportunity for us to discover new information and elements helping to give a more definite shape and enliven a plethora of issues, left neglected and even forgotten until today.
A good example of the above is the activity of the Romanian architects in Odessa and their later destiny, marred almost to its end by the horrors lived through during the Second World War. Hence the main thesis of our article. Documents in the Romanian Securitate archives are assisting us to build their professional and human portrait, along with other enthralling elements, trying to find out how their lifes – both social and professional – were affected by what happened in 1941-1944.
We already knew that the vast majority of Transnistria government’s officials were convinted for war crimes or crimes against the pease by the people’s court (1945-1946), but the fate of these architects remained unknown – or, at last, forgotten – until our research. Following the idea that they were simple technicians, our initial intuition was confirmed. Although they were arrested and investigated, in the end they were exonerated of any accusation related to their activity in Transnistria.
However, from a double perspective – both the criminal record from 1945 and their belonging to a social class destined to disappear – they were under the Securitate’s lens for many years, having a series of both social problems and, above all, professional. Their ascension was completely blocked, they were constantly under surveillance, their involvement in other political processes was attempted, their transformation into Securitate’s collaborators was desired.
The irony of fate is precisely that, relying exclusively on the documents of the former Securitate, we can recreate today the portraits of two architects who otherwise would have remained completely unknow.
BEYOND OTTOMAN HISTORY: THE CARAMOUSSALS AND THE EARLY MODERN MEDITERRANEAN
Authors: Apetrei Christian Nicolae
Published: April 2024

The article is concerned with a class of early modern Ottoman vessels, known as caramoussals. It reveals an ignored aspect of their past by providing evidence for the fact that these ships were owned, traded and used outside the boundaries of the Ottoman world. While historians have so far used available sources to determine the part played by caramoussals in Ottoman economic and military affairs, this paper refers to several neglected sources revealing the acquisition and capture of these vessels by Western Christians in order to reuse them. This explains their presence on the sea routes linking Western Europe to the Ottoman Empire, as well as on the domestic routes of some of the Mediterranean maritime powers, such as Venice. The sources analyzed here emphasize the topic as being relevant not only to Ottoman maritime history, but also to the history of early modern Mediterranean. Thus, they serve as an incentive to a comprehensive study of caramoussals within the framework of Mediterranean maritime history..
THE ACTIVITY OF FRENCH LEGATION IN BUCHAREST (1943)
Authors: Preutu Cristina
Published: April 2024

During the Second World War, the Romanian-French diplomatic relations were visibly disrupted due to the war alliances then existing, as well as by the conflict events. However, the long-standing friendship between the two states did not support a definitive break of diplomatic relations. Moreover, amid certain crucial moments at that time, the two states made known their mutual affinity and friendship and they assisted each other diplomatically in defending each other's national interests to the greatest extent. In this study, I would therefore focus on the highlights of the Romanian-French diplomatic collaboration throughout the year of 1943 and describe the main events that characterized the activity of the French legation in Bucharest. To the purpose of analyzing this chapter in the Romanian-French relations, I will foremost refer to documents in the CNSAS archive. These documents, reflecting a large part of the Gaullist Resistance activity inside the French legation in Bucharest, are unique and they aid with the understanding of the nature of the Romanian-French relations of those years.