bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 4 from Compensatory Functions and Interdependency of the DNA-Binding Domain of BRCA2 with the BRCA1–PALB2–BRCA2 Complex
Authors: Al Abo Muthana , Dejsuphong Donniphat , Hirota Kouji , Yonetani Yasukazu , Yamazoe Mitsuyoshi , Kurumizaka Hitoshi , Takeda Shunichi
Published: April 2023

PDF file - 41K, Cellular sensitivity of the indicated BRCA2 mutant cells to the DNA-damaging agents.
Supplementary Movie 3 from Curcumin Targets Breast Cancer Stem–like Cells with Microtentacles That Persist in Mammospheres and Promote Reattachment
Authors: Charpentier Monica S. , Whipple Rebecca A. , Vitolo Michele I. , Boggs Amanda E. , Slovic Jana , Thompson Keyata N. , Bhandary Lekhana , Martin Stuart S.
Published: April 2023

AVI file - 4552K, Live cell confocal imaging of HMLE mammosphere stained with CellMask Orange (red) and transduced with GFP-membrane (green) suspended over a glass surface. Cross-sections reveal McTNs from the GFP-membrane cell encircling other cells in the mammosphere.
Supplementary Movie 2 from Curcumin Targets Breast Cancer Stem–like Cells with Microtentacles That Persist in Mammospheres and Promote Reattachment
Authors: Charpentier Monica S. , Whipple Rebecca A. , Vitolo Michele I. , Boggs Amanda E. , Slovic Jana , Thompson Keyata N. , Bhandary Lekhana , Martin Stuart S.
Published: April 2023

AVI file - 5792K, Live cell confocal imaging of HMLE mammosphere stained with CellMask Orange (red) and transduced with GFP-membrane (green) suspended over a glass surface. Three-dimensional computer-rendered image reveals McTNs from the GFP-membrane cell encircling other cells in the mammosphere.
Supplementary Movie 1B from Curcumin Targets Breast Cancer Stem–like Cells with Microtentacles That Persist in Mammospheres and Promote Reattachment
Authors: Charpentier Monica S. , Whipple Rebecca A. , Vitolo Michele I. , Boggs Amanda E. , Slovic Jana , Thompson Keyata N. , Bhandary Lekhana , Martin Stuart S.
Published: April 2023

AVI file - 1232K, Microtentacles disappear upon treatment with microtubule polymerization inhibitor Colchicine.
Supplementary Figure Legend from Curcumin Targets Breast Cancer Stem–like Cells with Microtentacles That Persist in Mammospheres and Promote Reattachment
Authors: Charpentier Monica S. , Whipple Rebecca A. , Vitolo Michele I. , Boggs Amanda E. , Slovic Jana , Thompson Keyata N. , Bhandary Lekhana , Martin Stuart S.
Published: April 2023

PDF file - 85K
Supplementary Figure 1 from Curcumin Targets Breast Cancer Stem–like Cells with Microtentacles That Persist in Mammospheres and Promote Reattachment
Authors: Charpentier Monica S. , Whipple Rebecca A. , Vitolo Michele I. , Boggs Amanda E. , Slovic Jana , Thompson Keyata N. , Bhandary Lekhana , Martin Stuart S.
Published: April 2023

PDF file - 110K, Cellular viability assay reveals no significant differences in viability between HMLE stem-like and non-stem-like subpopulations upon treatment with colchicine.
Supplementary Methods from MDR1 Synonymous Polymorphisms Alter Transporter Specificity and Protein Stability in a Stable Epithelial Monolayer
Authors: Fung King Leung , Pan James , Ohnuma Shinobu , Lund Paul E. , Pixley Jessica N. , Kimchi-Sarfaty Chava , Ambudkar Suresh V. , Gottesman Michael M.
Published: April 2023

PDF file - 92K
Supplementary Figure 7 from Cancer Cells Exploit eIF4E2-Directed Synthesis of Hypoxia Response Proteins to Drive Tumor Progression
Authors: Uniacke James , Kishan Perera J. , Lachance Gabriel , Francisco Camille B. , Lee Stephen
Published: April 2023

PDF file - 657K, Reintroduction of exogenous eIF4E2 restores tumor cell proliferation.
Supplementary Figure 6 from Cancer Cells Exploit eIF4E2-Directed Synthesis of Hypoxia Response Proteins to Drive Tumor Progression
Authors: Uniacke James , Kishan Perera J. , Lachance Gabriel , Francisco Camille B. , Lee Stephen
Published: April 2023

PDF file - 1161K, Spheroid growth requires eIF4E2-directed protein synthesis.
Supplementary Figure 7 from A Rare Polymorphic Variant of NBS1 Reduces DNA Repair Activity and Elevates Chromosomal Instability
Authors: Yamamoto Yuki , Miyamoto Mamiko , Tatsuda Daisuke , Kubo Michiaki , Nakagama Hitoshi , Nakamura Yusuke , Satoh Hitoshi , Matsuda Koichi , Watanabe Toshiki , Ohta Tsutomu
Published: April 2023

PDF file - 71KB, The NBS1-I171V polymorphic variant reduced focus counts of RAD51 and BRCA1.
Supplementary Figure 5 from A Rare Polymorphic Variant of NBS1 Reduces DNA Repair Activity and Elevates Chromosomal Instability
Authors: Yamamoto Yuki , Miyamoto Mamiko , Tatsuda Daisuke , Kubo Michiaki , Nakagama Hitoshi , Nakamura Yusuke , Satoh Hitoshi , Matsuda Koichi , Watanabe Toshiki , Ohta Tsutomu
Published: April 2023

PDF file - 79KB, The NBS1-I171V polymorphic variant reduced focus counts of NBS1.
Supplementary Figure 4 from A Rare Polymorphic Variant of NBS1 Reduces DNA Repair Activity and Elevates Chromosomal Instability
Authors: Yamamoto Yuki , Miyamoto Mamiko , Tatsuda Daisuke , Kubo Michiaki , Nakagama Hitoshi , Nakamura Yusuke , Satoh Hitoshi , Matsuda Koichi , Watanabe Toshiki , Ohta Tsutomu
Published: April 2023

PDF file - 1374KB, The NBS1-I171V polymorphic variant exerted a dominant-negative effect on wild-type NBS1 reduce DSB repair.
Supplementary Figure 3 from A Rare Polymorphic Variant of NBS1 Reduces DNA Repair Activity and Elevates Chromosomal Instability
Authors: Yamamoto Yuki , Miyamoto Mamiko , Tatsuda Daisuke , Kubo Michiaki , Nakagama Hitoshi , Nakamura Yusuke , Satoh Hitoshi , Matsuda Koichi , Watanabe Toshiki , Ohta Tsutomu
Published: April 2023

PDF file - 1059KB, Impaired DSB repair pathway in other cells expressing an NBS1-I171V polymorphic variant.
Supplementary Figure 2 from Mechanisms of Resistance to Intermittent Androgen Deprivation in Patients with Prostate Cancer Identified by a Novel Computational Method
Authors: Morken Jason D. , Packer Aaron , Everett Rebecca A. , Nagy John D. , Kuang Yang
Published: April 2023

PDF file - 75KB, Figure S2. Serum-androgen plots.
Supplementary Table 4 from Attenuation of microRNA-126 Expression That Drives CD34+38− Stem/Progenitor Cells in Acute Myeloid Leukemia Leads to Tumor Eradication
Authors: de Leeuw David C. , Denkers Fedor , Olthof Marjolein C. , Rutten Arjo P. , Pouwels Walter , Jan Schuurhuis Gerrit , Ossenkoppele Gert J. , Smit Linda
Published: April 2023

XLSX file - 11KB, MicroRNA-126 is highly expressed in core binding factor AML: qRT-PCR results of miR-126 in CD34+CD38-ALDHlow/dim LSC and CD34+CD38+ALDHlow/dim leukemic progenitors in 18 AML patients. Cytogenetics indicates the presence of a CBF karyotype. Values are calculated using the dCT method with the mean of the LSC ct-values set to 1. Average and ratio, respectively indicates the averages and ratios of miR-126 expression in the LSC and progenitor fractions. CBF leukemias show higher expression of miR-126 compared to non-CBF leukemias. However the ratio of miR-126 expression between LSC and leukemic progenitors is not different in CBF and non-CBF leukemias.
Supplementary Figure 7 from Metastasis Suppressor KISS1 Seems to Reverse the Warburg Effect by Enhancing Mitochondrial Biogenesis
Authors: Liu Wen , Beck Benjamin H. , Vaidya Kedar S. , Nash Kevin T. , Feeley Kyle P. , Ballinger Scott W. , Pounds Keke M. , Denning Warren L. , Diers Anne R. , Landar Aimee , Dhar Animesh , Iwakuma Tomoo , Welch Danny R.
Published: April 2023

PDF file - 1105K, Supplemental Figure 7. KISS1 inhibits glucose uptake and activation of AMPK. A, Glucose uptake by C8161.9Vector (Vec), C8161.9KFMΔSS, C8161.9KFM and C8161.9KFM/shPGC1α cells was measured using 2-deoxyglucose uptake and normalized to total protein. B, C8161.9Vector, C8161.9KFM and C8161.9KFMdeltaSS cells were treated with AICAR followed by Western blot with antibodies for AMPK, phospho-AMPK (Thr172), mTOR , phospho-mTOR (Ser2448), KISS1 and GAPDH.
Supplementary Table 1 from Attenuation of microRNA-126 Expression That Drives CD34+38− Stem/Progenitor Cells in Acute Myeloid Leukemia Leads to Tumor Eradication
Authors: de Leeuw David C. , Denkers Fedor , Olthof Marjolein C. , Rutten Arjo P. , Pouwels Walter , Jan Schuurhuis Gerrit , Ossenkoppele Gert J. , Smit Linda
Published: April 2023

XLSX file - 9KB, Patient characteristics and stem cell frequencies: Patient characteristics and stem cell frequencies of samples used for miRNA expression profiling using microarray. Molecular aberrancy indicates the aberrancy as detected by routine molecular analysis of the patient at diagnosis. '-' indicates no abnormalities found in all molecular analysis tested (e.g. t(8;21), t(15;17), inv(16), NPM1, EVI1, CEBPA, and MLL). The fraction HSC within the CD34+ population indicates the CD34+CD38-ALDHhighLAPneg cells within the CD45+CD34+ cell compartment. For LSC the fraction of CD34+CD38-ALDHlow/dim cells were used. F, female; M, male; WBC, white blood cell count.
Supplementary Figure 3 from Metastasis Suppressor KISS1 Seems to Reverse the Warburg Effect by Enhancing Mitochondrial Biogenesis
Authors: Liu Wen , Beck Benjamin H. , Vaidya Kedar S. , Nash Kevin T. , Feeley Kyle P. , Ballinger Scott W. , Pounds Keke M. , Denning Warren L. , Diers Anne R. , Landar Aimee , Dhar Animesh , Iwakuma Tomoo , Welch Danny R.
Published: April 2023

PDF file - 1108K, Supplemental Figure 3. KISS1 enhances mitochondria gene expression. C8161.9Vector, C8161.9KFM, and C8161.9 cells were subjected to mitochondria gene profiling by Mitochondria PCR Array. Selected genes up-regulated (Blue) and down-regulated (Yellow) in C8161.9KFM were shown as in the table.
Supplementary Figures 1 - 7 from Mesenchymal Stem Cells Use IDO to Regulate Immunity in Tumor Microenvironment
Authors: Ling Weifang , Zhang Jimin , Yuan Zengrong , Ren Guangwen , Zhang Liying , Chen Xiaodong , Rabson Arnold B. , Roberts Arthur I. , Wang Ying , Shi Yufang
Published: April 2023

PDF file - 794KB, Immunosuppressive effect of another constitutive IDO-expressing MSC clone MSC-IDOc2 (S1); Expression of iNOS or IDO in MSCs upon cytokine stimulation and their effect on lymphocyte proliferation (S2); Effect of iNOS-/- MSCs on proliferation of activated human peripheral blood mononuclear cells (S3); In Situ expression and location of human IDO in the tumor tissue (S4); Effect of IDO-expressing MSCs on the distribution of immune cell subpopulations in peripheral blood and tumor tissues (S5); Effect of IDO-expressing MSCs on the distribution of immune cell subpopulations in peripheral blood and tumor tissues (S6); Effect of IDO-expressing MSCs on the distribution of immune cell subpopulations in peripheral blood and tumor tissues (S7).
Supplementary Table 2 from Genome-wide Profiling of Genetic Synthetic Lethality Identifies CDK12 as a Novel Determinant of PARP1/2 Inhibitor Sensitivity
Authors: Bajrami Ilirjana , Frankum Jessica R. , Konde Asha , Miller Rowan E. , Rehman Farah L. , Brough Rachel , Campbell James , Sims David , Rafiq Rumana , Hooper Sean , Chen Lina , Kozarewa Iwanka , Assiotis Ioannis , Fenwick Kerry , Natrajan Rachael , Lord Christopher J. , Ashworth Alan
Published: April 2023

PDF file 543K, Supplementary Table S2 shRNA constructs with Olaparib Drug Effect Z scores <-1.96
Supplementary Figure 8 from Blocking Lactate Export by Inhibiting the Myc Target MCT1 Disables Glycolysis and Glutathione Synthesis
Authors: Doherty Joanne R. , Yang Chunying , Scott Kristen E.N. , Cameron Michael D. , Fallahi Mohammad , Li Weimin , Hall Mark A. , Amelio Antonio L. , Mishra Jitendra K. , Li Fangzheng , Tortosa Mariola , Genau Heide Marika , Rounbehler Robert J. , Lu Yunqi , Dang Chi V. , Kumar K. Ganesh , Butler Andrew A. , Bannister Thomas D. , Hooper Andrea T. , Unsal-Kacmaz Keziban , Roush William R. , Cleveland John L.
Published: April 2023

PDF file - 332K, Schematic of selection for SR13800 resistance in Raji BL cells and levels of MCT1, MCT4 and LDH in SR13800-resistant cells. Mitotracker green staining of Raji BL cells treated with SR13800 and metformin. Schematic of metabolic pathways that are disrupted by blocking lactate transport through MCT1.
Supplementary Figure 3 from Inhibitor-Sensitive FGFR2 and FGFR3 Mutations in Lung Squamous Cell Carcinoma
Authors: Liao Rachel G. , Jung Joonil , Tchaicha Jeremy , Wilkerson Matthew D. , Sivachenko Andrey , Beauchamp Ellen M. , Liu Qingsong , Pugh Trevor J. , Pedamallu Chandra Sekhar , Hayes D. Neil , Gray Nathanael S. , Getz Gad , Wong Kwok-Kin , Haddad Robert I. , Meyerson Matthew , Hammerman Peter S.
Published: April 2023

PDF file - 203K, Extracellular domain dimerization studies.
Supplementary Figure 1 from Inhibitor-Sensitive FGFR2 and FGFR3 Mutations in Lung Squamous Cell Carcinoma
Authors: Liao Rachel G. , Jung Joonil , Tchaicha Jeremy , Wilkerson Matthew D. , Sivachenko Andrey , Beauchamp Ellen M. , Liu Qingsong , Pugh Trevor J. , Pedamallu Chandra Sekhar , Hayes D. Neil , Gray Nathanael S. , Getz Gad , Wong Kwok-Kin , Haddad Robert I. , Meyerson Matthew , Hammerman Peter S.
Published: April 2023

PDF file - 76K, FGFR2 and FGFR3 isoform expression in mutated and amplified samples.
Supplementary Figure 3 from Blocking Lactate Export by Inhibiting the Myc Target MCT1 Disables Glycolysis and Glutathione Synthesis
Authors: Doherty Joanne R. , Yang Chunying , Scott Kristen E.N. , Cameron Michael D. , Fallahi Mohammad , Li Weimin , Hall Mark A. , Amelio Antonio L. , Mishra Jitendra K. , Li Fangzheng , Tortosa Mariola , Genau Heide Marika , Rounbehler Robert J. , Lu Yunqi , Dang Chi V. , Kumar K. Ganesh , Butler Andrew A. , Bannister Thomas D. , Hooper Andrea T. , Unsal-Kacmaz Keziban , Roush William R. , Cleveland John L.
Published: April 2023

PDF file - 76K, Expression profiling, RNA-seq and MYC chromatin immunoprecipitation analyses of MCT1 in human P493-6 B cells. MCT1, MCT2, MCT3 and MCT4 mRNA levels in Raji BL and MCF7 breast cancer cells.
Supplementary Figure Legends from Chromosome 10, Frequently Lost in Human Melanoma, Encodes Multiple Tumor-Suppressive Functions
Authors: Kwong Lawrence N. , Chin Lynda
Published: April 2023

PDF file - 57KB
Supplementary Figure 2 from PP2A-B55β Antagonizes Cyclin E1 Proteolysis and Promotes Its Dysregulation in Cancer
Authors: Tan YingMeei , Sun Dahui , Jiang Weijian , Klotz-Noack Kathleen , Vashisht Ajay A. , Wohlschlegel James , Widschwendter Martin , Spruck Charles
Published: April 2023

PDF file - 167KB, Transfection of MDA-MB-231 cells with three different B55beta siRNAs decreases cyclin E1 protein level. Cells were harvested 48 hrs post-transfection. All subsequent experiments were performed using B55beta-siRNA-2. qPCR data showing efficiency of B55beta knockdown and potential effects on cyclin E1 expression are shown below. Expression was normalized to control (scrambled) siRNA.
Supplementary Figure 1 from PP2A-B55β Antagonizes Cyclin E1 Proteolysis and Promotes Its Dysregulation in Cancer
Authors: Tan YingMeei , Sun Dahui , Jiang Weijian , Klotz-Noack Kathleen , Vashisht Ajay A. , Wohlschlegel James , Widschwendter Martin , Spruck Charles
Published: April 2023

PDF file - 162KB, B56beta and B56delta do not associate with endogenous cyclin E1. HeLa cells were transfected with plasmids that express Flag-B56beta or Flag-B56delta and extracts (20 mg) immunoprecipitated with either IgG (control) or anti-Flag antibodies. Western blots were then probed with anti-cyclin E1 or anti-Flag antibodies. WCE indicates position of cyclin E1 in the gel.
Supplementary Figure 2 from Chromosome 10, Frequently Lost in Human Melanoma, Encodes Multiple Tumor-Suppressive Functions
Authors: Kwong Lawrence N. , Chin Lynda
Published: April 2023

PDF file - 32KB, List of the 57 downregulated, candidate tumor suppressor genes identified by expression microarray analysis.
Supplementary Methods and References from Adiponectin Receptor Signaling on Dendritic Cells Blunts Antitumor Immunity
Authors: Tan Peng H. , Tyrrell Helen E.J. , Gao Liquan , Xu Danmei , Quan Jianchao , Gill Dipender , Rai Lena , Ding Yunchuan , Plant Gareth , Chen Yuan , Xue John Z. , Handa Ashok I. , Greenall Michael J. , Walsh Kenneth , Xue Shao-An
Published: April 2023

Description of additional methods and procedures used in the study. Also includes supplementary references.
Supplementary Table 1 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells
Authors: Goc Jérémy , Germain Claire , Vo-Bourgais Thi Kim Duy , Lupo Audrey , Klein Christophe , Knockaert Samantha , de Chaisemartin Luc , Ouakrim Hanane , Becht Etienne , Alifano Marco , Validire Pierre , Remark Romain , Hammond Scott A. , Cremer Isabelle , Damotte Diane , Fridman Wolf-Herman , Sautès-Fridman Catherine , Dieu-Nosjean Marie-Caroline
Published: April 2023

PDF file - 99K, Baseline characteristics of the NSCLC fresh tumors enrolled in the prospective study.
Supplementary Figure 8 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells
Authors: Goc Jérémy , Germain Claire , Vo-Bourgais Thi Kim Duy , Lupo Audrey , Klein Christophe , Knockaert Samantha , de Chaisemartin Luc , Ouakrim Hanane , Becht Etienne , Alifano Marco , Validire Pierre , Remark Romain , Hammond Scott A. , Cremer Isabelle , Damotte Diane , Fridman Wolf-Herman , Sautès-Fridman Catherine , Dieu-Nosjean Marie-Caroline
Published: April 2023

PDF file - 308K, Characterization of immune cells in and out TLS.
Supplementary Figure 7 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells
Authors: Goc Jérémy , Germain Claire , Vo-Bourgais Thi Kim Duy , Lupo Audrey , Klein Christophe , Knockaert Samantha , de Chaisemartin Luc , Ouakrim Hanane , Becht Etienne , Alifano Marco , Validire Pierre , Remark Romain , Hammond Scott A. , Cremer Isabelle , Damotte Diane , Fridman Wolf-Herman , Sautès-Fridman Catherine , Dieu-Nosjean Marie-Caroline
Published: April 2023

PDF file - 271K, Coordination of gene expression levels related to immune populations, TLS, Th-orientation, cytotoxicity, T-cell activation, immuno-suppression, inflammation and angiogenesis according to the high density of mature DC.
Supplementary Figure S3 from Adiponectin Receptor Signaling on Dendritic Cells Blunts Antitumor Immunity
Authors: Tan Peng H. , Tyrrell Helen E.J. , Gao Liquan , Xu Danmei , Quan Jianchao , Gill Dipender , Rai Lena , Ding Yunchuan , Plant Gareth , Chen Yuan , Xue John Z. , Handa Ashok I. , Greenall Michael J. , Walsh Kenneth , Xue Shao-An
Published: April 2023

Both APN receptors can independently modulate DC function.
Supplementary Figure Legends from Adiponectin Receptor Signaling on Dendritic Cells Blunts Antitumor Immunity
Authors: Tan Peng H. , Tyrrell Helen E.J. , Gao Liquan , Xu Danmei , Quan Jianchao , Gill Dipender , Rai Lena , Ding Yunchuan , Plant Gareth , Chen Yuan , Xue John Z. , Handa Ashok I. , Greenall Michael J. , Walsh Kenneth , Xue Shao-An
Published: April 2023

Legend for Supplementary Figures S1-S12.
Supplementary Methods from Integrin αvβ6 Promotes an Osteolytic Program in Cancer Cells by Upregulating MMP2
Authors: Dutta Anindita , Li Jing , Lu Huimin , Akech Jacqueline , Pratap Jitesh , Wang Tao , Zerlanko Brad J. , FitzGerald Thomas J. , Jiang Zhong , Birbe Ruth , Wixted John , Violette Shelia M. , Stein Janet L. , Stein Gary S. , Lian Jane B. , Languino Lucia R.
Published: April 2023

PDF - 69K, Description of additional methods and procedures used in the study. Also includes supplementary references.
Supplementary Figures 1 - 6, Table 1, Methods from Reprogramming the Chromatin Landscape: Interplay of the Estrogen and Glucocorticoid Receptors at the Genomic Level
Authors: Miranda Tina B. , Voss Ty C. , Sung Myong-Hee , Baek Songjoon , John Sam , Hawkins Mary , Grøntved Lars , Schiltz R. Louis , Hager Gordon L.
Published: April 2023

Supplementary Figure 1. ER binds at pre-programmed sites in MCF7 cells and genomic regions for ER and GR ChIPs. Supplementary Figure 2. ER and GR binding modules. Supplementary Figure 3. Changes in gene expression upon treatment of cells with Dex and E2. Supplementary Figure 4. Changes in chromatin accessibility at the different binding modules. Supplementary Figure 5. Motif composition at induced ER and GR binding events. Supplementary Figure 6. Analysis of the ER DNA binding mutantâ€™s ability to bind to specific sites.
Supplementary Table 7 from Fusobacterium in Colonic Flora and Molecular Features of Colorectal Carcinoma
Authors: Tahara Tomomitsu , Yamamoto Eiichiro , Suzuki Hiromu , Maruyama Reo , Chung Woonbok , Garriga Judith , Jelinek Jaroslav , Yamano Hiro-o , Sugai Tamotsu , An Byonggu , Shureiqi Imad , Toyota Minoru , Kondo Yutaka , Estécio Marcos R.H. , Issa Jean-Pierre J.
Published: April 2023

XLSX file - 97K, Gene Ontology analysis for identification of enrichment for specific functional categories among the mutated genes.
Supplementary Table 5 from Fusobacterium in Colonic Flora and Molecular Features of Colorectal Carcinoma
Authors: Tahara Tomomitsu , Yamamoto Eiichiro , Suzuki Hiromu , Maruyama Reo , Chung Woonbok , Garriga Judith , Jelinek Jaroslav , Yamano Hiro-o , Sugai Tamotsu , An Byonggu , Shureiqi Imad , Toyota Minoru , Kondo Yutaka , Estécio Marcos R.H. , Issa Jean-Pierre J.
Published: April 2023

XLSX file - 92K, Association between high amount of Fusobacterium and clinical and molecular subtypes of CRCs in CIMP1 CRCs.
Supplementary Table 2 from Fusobacterium in Colonic Flora and Molecular Features of Colorectal Carcinoma
Authors: Tahara Tomomitsu , Yamamoto Eiichiro , Suzuki Hiromu , Maruyama Reo , Chung Woonbok , Garriga Judith , Jelinek Jaroslav , Yamano Hiro-o , Sugai Tamotsu , An Byonggu , Shureiqi Imad , Toyota Minoru , Kondo Yutaka , Estécio Marcos R.H. , Issa Jean-Pierre J.
Published: April 2023

XLSX file - 9K, Correlation between F.nucleatum and Pan-fuso bacterium in cancer tissues.
Supplementary Table 1 from Fusobacterium in Colonic Flora and Molecular Features of Colorectal Carcinoma
Authors: Tahara Tomomitsu , Yamamoto Eiichiro , Suzuki Hiromu , Maruyama Reo , Chung Woonbok , Garriga Judith , Jelinek Jaroslav , Yamano Hiro-o , Sugai Tamotsu , An Byonggu , Shureiqi Imad , Toyota Minoru , Kondo Yutaka , Estécio Marcos R.H. , Issa Jean-Pierre J.
Published: April 2023

XLSX file - 10K, Primer sequences used in pyrosequencing.
Supplementary Figure 4 from Cofilin Drives Cell-Invasive and Metastatic Responses to TGF-β in Prostate Cancer
Authors: Collazo Joanne , Zhu Beibei , Larkin Spencer , Martin Sarah K. , Pu Hong , Horbinski Craig , Koochekpour Shahriar , Kyprianou Natasha
Published: April 2023

PDF file - 77KB, Characterization of human prostate cancer associated fibroblasts (CAFs). Panel A, We generated five distinct primary cultures of human prostate cancer associated fibroblasts from prostatectomy specimens. Western blot of CAFs, PCa-Str2 to PCaStr6 comparatively analyzed with human prostate cancer epithelial cell lines (LNCaP, PC-3, DU-145) for the expression of AR, PSMA (prostate specific membrane antigen), cytokeratin-18 (CK-18), smooth-muscle α-actin and c-Met. Panel B, Immunofluorescent tracing of human prostate cancer epithelial cells and prostate cancer associated fibroblasts. PC-3 prostate cancer cells (red) and CAFs (green) were fluorescently labeled with either Invitrogen Cell tracker Orange CMRA or Cell tracker Green respectively and co-cultured for 48hrs. Merged image indicates the specific staining identifying each cell type.
Supplementary Figure 2 from Fusobacterium in Colonic Flora and Molecular Features of Colorectal Carcinoma
Authors: Tahara Tomomitsu , Yamamoto Eiichiro , Suzuki Hiromu , Maruyama Reo , Chung Woonbok , Garriga Judith , Jelinek Jaroslav , Yamano Hiro-o , Sugai Tamotsu , An Byonggu , Shureiqi Imad , Toyota Minoru , Kondo Yutaka , Estécio Marcos R.H. , Issa Jean-Pierre J.
Published: April 2023

PDF file - 44K, Distribution of Fusobacterium in in CRC tissues (n=149).
Supplementary Figure 1 from Cofilin Drives Cell-Invasive and Metastatic Responses to TGF-β in Prostate Cancer
Authors: Collazo Joanne , Zhu Beibei , Larkin Spencer , Martin Sarah K. , Pu Hong , Horbinski Craig , Koochekpour Shahriar , Kyprianou Natasha
Published: April 2023

PDF file - 50KB, Effect of cofilin activation status or loss on prostate cancer cell death and invasion. Panel A, Neither a mutation on phosphorylation site (S3ACFL) nor silencing of cofilin expression (shCFL1) has a significant effect on cell viability (MTT). Panel B, Consequence of cofilin activation/expression status on TGF-β mediated prostate cancer cell invasion.
Supplementary Materials and Methods from Alarmin IL-33 Acts as an Immunoadjuvant to Enhance Antigen-Specific Tumor Immunity
Authors: Villarreal Daniel O. , Wise Megan C. , Walters Jewell N. , Reuschel Emma L. , Choi Min Joung , Obeng-Adjei Nyamekye , Yan Jian , Morrow Matthew P. , Weiner David B.
Published: April 2023

PDF file - 107KB
Supplementary Video 3 from HuR Posttranscriptionally Regulates WEE1: Implications for the DNA Damage Response in Pancreatic Cancer Cells
Authors: Lal Shruti , Burkhart Richard A. , Beeharry Neil , Bhattacharjee Vikram , Londin Eric R. , Cozzitorto Joseph A. , Romeo Carmella , Jimbo Masaya , Norris Zoë A. , Yeo Charles J. , Sawicki Janet A. , Winter Jordan M. , Rigoutsos Isidore , Yen Timothy J. , Brody Jonathan R.
Published: April 2023

AVI file - 8882KB, Untreated siRNA HuR cells progressing through mitosis.
Supplementary Figure 3 from EGF Receptor Activates MET through MAPK to Enhance Non–Small Cell Lung Carcinoma Invasion and Brain Metastasis
Authors: Breindel Jerrica L. , Haskins Jonathan W. , Cowell Elizabeth P. , Zhao Minghui , Nguyen Don X. , Stern David F.
Published: April 2023

PDF file - 1952K, EGFR activation of MET in 32D cells is dependent on transcription, translation, and intermediary signaling.
Supplementary Video 2 from HuR Posttranscriptionally Regulates WEE1: Implications for the DNA Damage Response in Pancreatic Cancer Cells
Authors: Lal Shruti , Burkhart Richard A. , Beeharry Neil , Bhattacharjee Vikram , Londin Eric R. , Cozzitorto Joseph A. , Romeo Carmella , Jimbo Masaya , Norris Zoë A. , Yeo Charles J. , Sawicki Janet A. , Winter Jordan M. , Rigoutsos Isidore , Yen Timothy J. , Brody Jonathan R.
Published: April 2023

AVI file - 8881KB, siRNA HuR cells progressing through mitosis after MMC treatment.
Supplementary Figure 2 from EGF Receptor Activates MET through MAPK to Enhance Non–Small Cell Lung Carcinoma Invasion and Brain Metastasis
Authors: Breindel Jerrica L. , Haskins Jonathan W. , Cowell Elizabeth P. , Zhao Minghui , Nguyen Don X. , Stern David F.
Published: April 2023

PDF file - 938K, Specificity of EGFR and MET inhibitors in 32D cells.
Supplementary Table 1 from HuR Posttranscriptionally Regulates WEE1: Implications for the DNA Damage Response in Pancreatic Cancer Cells
Authors: Lal Shruti , Burkhart Richard A. , Beeharry Neil , Bhattacharjee Vikram , Londin Eric R. , Cozzitorto Joseph A. , Romeo Carmella , Jimbo Masaya , Norris Zoë A. , Yeo Charles J. , Sawicki Janet A. , Winter Jordan M. , Rigoutsos Isidore , Yen Timothy J. , Brody Jonathan R.
Published: April 2023

PDF file - 64KB, Class of drugs used in the drug sensitivity assays performed in MiaPaCa2 cells against siRNA Control and HuR, respective IC50 of each drug identified.
Supplementary Figure Legends, Movie Legends from HuR Posttranscriptionally Regulates WEE1: Implications for the DNA Damage Response in Pancreatic Cancer Cells
Authors: Lal Shruti , Burkhart Richard A. , Beeharry Neil , Bhattacharjee Vikram , Londin Eric R. , Cozzitorto Joseph A. , Romeo Carmella , Jimbo Masaya , Norris Zoë A. , Yeo Charles J. , Sawicki Janet A. , Winter Jordan M. , Rigoutsos Isidore , Yen Timothy J. , Brody Jonathan R.
Published: April 2023

PDF file - 83KB
Supplementary Methods, Figures 1 - 8, Tables 1 - 2 from Cyclophilin B Supports Myc and Mutant p53-Dependent Survival of Glioblastoma Multiforme Cells
Authors: Choi Jae Won , Schroeder Mark A. , Sarkaria Jann N. , Bram Richard J.
Published: April 2023

PDF file - 1026K, Figure S1. Pharmacological inhibition of Cyclophilin B reduces glioblastoma cell survival. Figure S2. Inhibition of MAPK signaling prevents CypB knockdown-induced senescence. Figure S3. Cyclophilin B controls p53 expression. Figure S4. Cyclosporine dimer treatment has a synergistic effect with ER stress-induced cell death. Figure S5. Several survival signals including JAK2, CHK1, mutant p53 are suppressed by CypB knockdown. Figure S6. Worse outcome in astrocytoma patients having higher CypB expression. Figure S7. Better outcome in patients with tumors carrying deletions of PPIB. Figure S8. Model for the proposed mechanism of cyclophilin B targeting in glioblastoma multiforme therapy. Table S1. Up-regulated genes in CypB depleted U251 GBM cells (>3 fold). Table S2. Down-regulated genes in CypB depleted U251 GBM cells (>3 fold).
Supplementary Figure 4 from VISTA Is an Immune Checkpoint Molecule for Human T Cells
Authors: Lines J. Louise , Pantazi Eirini , Mak Justin , Sempere Lorenzo F. , Wang Li , O'Connell Samuel , Ceeraz Sabrina , Suriawinata Arief A. , Yan Shaofeng , Ernstoff Marc S. , Noelle Randolph
Published: April 2023

PDF file - 20KB, The suppressive effect of VISTA is stable. Bulk CD4 T cells were purified from human PBMCs by magnetic bead selection. Cells were CFSE labeled and stimulated for 3 days with 2.5ug/ml anti-CD3 co-coated with 0, 2.5, 5 or 10ug/ml of VISTA-Ig. Control-Ig was used to bring the concentration of fusion protein to 10ug/ml in all wells. Cells were then moved to anti-CD3 in the absence of fusion protein. Percentage CFSE low cells are shown as mean +/- SD. Data is representative of at least two separate experiments.
Supplementary Figures 1 - 6 from JNK Signaling Mediates EPHA2-Dependent Tumor Cell Proliferation, Motility, and Cancer Stem Cell–like Properties in Non–Small Cell Lung Cancer
Authors: Song Wenqiang , Ma Yufang , Wang Jialiang , Brantley-Sieders Dana , Chen Jin
Published: April 2023

PDF file - 612K, Knockdown of EPHA2 inhibits cell viability and tumor cell migration in NSCLC cells (S1); Effects of EPHA2 on JNK and c-JUN expression and activities in NSCLCs (S2); SP600125 inhibits phosphorylation of JNK and c-JUN and cell viability (S3); Knockdown of EPHA2 inhibits tumor formation in vivo (S4); Knockdown of EPHA2 in H1650 and H23 cells decreases ALDH-positive population (S5); Sorted ALDH-positive cells are enriched with cancer stem-like cells (S6).
Supplementary Figure Legends from JNK Signaling Mediates EPHA2-Dependent Tumor Cell Proliferation, Motility, and Cancer Stem Cell–like Properties in Non–Small Cell Lung Cancer
Authors: Song Wenqiang , Ma Yufang , Wang Jialiang , Brantley-Sieders Dana , Chen Jin
Published: April 2023

PDF file - 27K
Supplemental Table S1 from ATR Inhibitors VE-821 and VX-970 Sensitize Cancer Cells to Topoisomerase I Inhibitors by Disabling DNA Replication Initiation and Fork Elongation Responses
Authors: Jossé Rozenn , Martin Scott E. , Guha Rajarshi , Ormanoglu Pinar , Pfister Thomas D. , Reaper Philip M. , Barnes Christopher S. , Jones Julie , Charlton Peter , Pollard John R. , Morris Joel , Doroshow James H. , Pommier Yves
Published: April 2023

Supplemental Table S1. RSA generated p-values are listed along with corresponding false discovery rates (FDR)*. *Benjamini, Yoav; Hochberg, Yosef (1995). "Controlling the false discovery rate: a practical and powerful approach to multiple testing". Journal of the Royal Statistical Society, Series B (Methodological) 57 (1): 289-300.
Supplemental Figure S3 from ATR Inhibitors VE-821 and VX-970 Sensitize Cancer Cells to Topoisomerase I Inhibitors by Disabling DNA Replication Initiation and Fork Elongation Responses
Authors: Jossé Rozenn , Martin Scott E. , Guha Rajarshi , Ormanoglu Pinar , Pfister Thomas D. , Reaper Philip M. , Barnes Christopher S. , Jones Julie , Charlton Peter , Pollard John R. , Morris Joel , Doroshow James H. , Pommier Yves
Published: April 2023

Supplemental Figure S3. The ATR inhibitor VX-970 sensitizes COLO 205 colorectal cancer cells to SN-38. COLO 205 cells were treated with VX-970 and SN-38 for 48h and cytotoxicity was measured by MTS assay. A. Synergy was analyzed by Bliss at the 95% interval using MacSynergy II software. B. Curve shift analysis.
Supplementary Table 4A from shRNA Kinome Screen Identifies TBK1 as a Therapeutic Target for HER2+ Breast Cancer
Authors: Deng Tao , Liu Jeff C. , Chung Philip E.D. , Uehling David , Aman Ahmed , Joseph Babu , Ketela Troy , Jiang Zhe , Schachter Nathan F. , Rottapel Robert , Egan Sean E. , Al-awar Rima , Moffat Jason , Zacksenhaus Eldad
Published: April 2023

PDF file - 51KB, Supplementary Table S4a lists gene sets enriched in TBK1-II treated HER2+ breast cancer cells.
Supplemental Figure S2 from ATR Inhibitors VE-821 and VX-970 Sensitize Cancer Cells to Topoisomerase I Inhibitors by Disabling DNA Replication Initiation and Fork Elongation Responses
Authors: Jossé Rozenn , Martin Scott E. , Guha Rajarshi , Ormanoglu Pinar , Pfister Thomas D. , Reaper Philip M. , Barnes Christopher S. , Jones Julie , Charlton Peter , Pollard John R. , Morris Joel , Doroshow James H. , Pommier Yves
Published: April 2023

Supplemental Figure S2. Candidates with a majority of siRNAs inducing a > 4- fold shift in CPT EC50 (minimum of 7 siRNAs tested; left Qiagen siRNAs; right Ambion). Corresponding catalog numbers are listed in chart legends.
Supplementary Table 3 from shRNA Kinome Screen Identifies TBK1 as a Therapeutic Target for HER2+ Breast Cancer
Authors: Deng Tao , Liu Jeff C. , Chung Philip E.D. , Uehling David , Aman Ahmed , Joseph Babu , Ketela Troy , Jiang Zhe , Schachter Nathan F. , Rottapel Robert , Egan Sean E. , Al-awar Rima , Moffat Jason , Zacksenhaus Eldad
Published: April 2023

PDF file - 48KB, Supplementary Table S3 lists hits on Her2/Neu monolayer cells only.
Supplemental Figure S1 from ATR Inhibitors VE-821 and VX-970 Sensitize Cancer Cells to Topoisomerase I Inhibitors by Disabling DNA Replication Initiation and Fork Elongation Responses
Authors: Jossé Rozenn , Martin Scott E. , Guha Rajarshi , Ormanoglu Pinar , Pfister Thomas D. , Reaper Philip M. , Barnes Christopher S. , Jones Julie , Charlton Peter , Pollard John R. , Morris Joel , Doroshow James H. , Pommier Yves
Published: April 2023

Supplemental Figure S1. Top candidates are enriched in known protein-protein interactions as determined by IPA. This network was generated through an IPA core analysis of genes scoring p {less than or equal to} 0.001 by RSA. The analysis considered only known direct relationships between genes, and used the ~7,000 genes represented in the screen as background. Genes scoring p {less than or equal to} 0.001 are highlighted in red. The network was the top scoring IPA network (score = 44).
Supplementary Table 1 from shRNA Kinome Screen Identifies TBK1 as a Therapeutic Target for HER2+ Breast Cancer
Authors: Deng Tao , Liu Jeff C. , Chung Philip E.D. , Uehling David , Aman Ahmed , Joseph Babu , Ketela Troy , Jiang Zhe , Schachter Nathan F. , Rottapel Robert , Egan Sean E. , Al-awar Rima , Moffat Jason , Zacksenhaus Eldad
Published: April 2023

PDF file - 43KB, Supplementary Table S1 lists hits on Her2/Neu spheres only.
Supplementary Figure Legends, Table 1 from Increased Dietary Vitamin D Suppresses MAPK Signaling, Colitis, and Colon Cancer
Authors: Meeker Stacey , Seamons Audrey , Paik Jisun , Treuting Piper M. , Brabb Thea , Grady William M. , Maggio-Price Lillian
Published: April 2023

PDF file - 155K, Primer sequences.
Supplementary Figure 5 from shRNA Kinome Screen Identifies TBK1 as a Therapeutic Target for HER2+ Breast Cancer
Authors: Deng Tao , Liu Jeff C. , Chung Philip E.D. , Uehling David , Aman Ahmed , Joseph Babu , Ketela Troy , Jiang Zhe , Schachter Nathan F. , Rottapel Robert , Egan Sean E. , Al-awar Rima , Moffat Jason , Zacksenhaus Eldad
Published: April 2023

PDF file - 753KB, Supplementary Figure S5 shows representative images of HCC1954 and SKBR3 HER2+ BC cells transduced with indicated lenti-shRNA against human Tbk1 or lenti-GFP.
Supplementary Table S1 from LIMD2 Is a Small LIM-Only Protein Overexpressed in Metastatic Lesions That Regulates Cell Motility and Tumor Progression by Directly Binding to and Activating the Integrin-Linked Kinase
Authors: Peng Hongzhuang , Talebzadeh-Farrooji Mehdi , Osborne Michael J. , Prokop Jeremy W. , McDonald Paul C. , Karar Jayashree , Hou Zhaoyuan , He Mei , Kebebew Electron , Orntoft Torben , Herlyn Meenhard , Caton Andrew J. , Fredericks William , Malkowicz Bruce , Paterno Christopher S. , Carolin Alexandra S. , Speicher David W. , Skordalakes Emmanuel , Huang Qihong , Dedhar Shoukat , Borden Katherine L.B. , Rauscher Frank J.
Published: April 2023

Data collection and refinement statistics for the LIMD2 protein.
Data Supplement from TLR7 Promotes Tumor Progression, Chemotherapy Resistance, and Poor Clinical Outcomes in Non–Small Cell Lung Cancer
Authors: Chatterjee Saradiya , Crozet Lucile , Damotte Diane , Iribarren Kristina , Schramm Catherine , Alifano Marco , Lupo Audrey , Cherfils-Vicini Julien , Goc Jeremy , Katsahian Sandrine , Younes Mohammad , Dieu-Nosjean Marie Caroline , Fridman Wolf Herman , Sautès-Fridman Catherine , Cremer Isabelle
Published: April 2023

Supplemental Figures 1-10. Supplementary figure 1 shows that TLR7 antagonist IRS661 specifically blocks TLR7 expression by human A549 cells Supplementary figure 2 shows that TLR7 agonist induces chemoresistance in murine LL/2 cells Supplementary figure 3 shows the pro-tumoral effect of TLR7 stimulation with increasing doses of chemotherapy Supplementary figure 4 shows that Stimulation of TLR7 favors tumor growth and chemoresistance of murine LL/2 cells while TLR7 blockade with an antagonist inhibits tumor growth Supplementary figure 5 shows that TLR7 stimulation induces myeloid cell recruitment into LL/2 tumors in immunocompetent C57BL/6 mice Supplementary figure 6 shows Determining the optimal cutoff for the cohort of patients not treated with neo-adjuvant chemotherapy Supplementary figure 7 shows Determining the optimal cutoff for the cohort of patients treated with neo-adjuvant chemotherapy Supplementary figure 8 shows that non-responders patients to neo-adjuvant chemotherapy have a poor prognosis Supplementary figure 9 shows the correlation graph for TLR7 expression by tumor cells in metastatic lymph nodes and in primary lung tumor, after treatment with neo-adjuvant chemotherapy Supplementary figure 10 shows that High TLR7 expression on tumor cells is associated with low response to neo-adjuvant chemotherapy
Supplementary Figure S5 from LIMD2 Is a Small LIM-Only Protein Overexpressed in Metastatic Lesions That Regulates Cell Motility and Tumor Progression by Directly Binding to and Activating the Integrin-Linked Kinase
Authors: Peng Hongzhuang , Talebzadeh-Farrooji Mehdi , Osborne Michael J. , Prokop Jeremy W. , McDonald Paul C. , Karar Jayashree , Hou Zhaoyuan , He Mei , Kebebew Electron , Orntoft Torben , Herlyn Meenhard , Caton Andrew J. , Fredericks William , Malkowicz Bruce , Paterno Christopher S. , Carolin Alexandra S. , Speicher David W. , Skordalakes Emmanuel , Huang Qihong , Dedhar Shoukat , Borden Katherine L.B. , Rauscher Frank J.
Published: April 2023

Asymmetry in electrostatic surface of PINCH LIM1 and LIMD2 domains.
Supplementary Figure S4 from LIMD2 Is a Small LIM-Only Protein Overexpressed in Metastatic Lesions That Regulates Cell Motility and Tumor Progression by Directly Binding to and Activating the Integrin-Linked Kinase
Authors: Peng Hongzhuang , Talebzadeh-Farrooji Mehdi , Osborne Michael J. , Prokop Jeremy W. , McDonald Paul C. , Karar Jayashree , Hou Zhaoyuan , He Mei , Kebebew Electron , Orntoft Torben , Herlyn Meenhard , Caton Andrew J. , Fredericks William , Malkowicz Bruce , Paterno Christopher S. , Carolin Alexandra S. , Speicher David W. , Skordalakes Emmanuel , Huang Qihong , Dedhar Shoukat , Borden Katherine L.B. , Rauscher Frank J.
Published: April 2023

The cell surface area was measured for breast cancer cell lines MDAMB231 (parental, LIMD2-Si5, restoration with vector and LIMD2) using Image-Pro Plus 7.0 program.
Data Supplement from BMP4 Inhibits Breast Cancer Metastasis by Blocking Myeloid-Derived Suppressor Cell Activity
Authors: Cao Yuan , Slaney Clare Y. , Bidwell Bradley N. , Parker Belinda S. , Johnstone Cameron N. , Rautela Jai , Eckhardt Bedrich L. , Anderson Robin L.
Published: April 2023

Supplementary Table 2. Gene ontology analysis of clusters (P < 0.05) up-regulated by BMP4 in primary tumors.
Supplementary Figure Legends and References from LIMD2 Is a Small LIM-Only Protein Overexpressed in Metastatic Lesions That Regulates Cell Motility and Tumor Progression by Directly Binding to and Activating the Integrin-Linked Kinase
Authors: Peng Hongzhuang , Talebzadeh-Farrooji Mehdi , Osborne Michael J. , Prokop Jeremy W. , McDonald Paul C. , Karar Jayashree , Hou Zhaoyuan , He Mei , Kebebew Electron , Orntoft Torben , Herlyn Meenhard , Caton Andrew J. , Fredericks William , Malkowicz Bruce , Paterno Christopher S. , Carolin Alexandra S. , Speicher David W. , Skordalakes Emmanuel , Huang Qihong , Dedhar Shoukat , Borden Katherine L.B. , Rauscher Frank J.
Published: April 2023

Legend for Supplementary Figures S1-S6. Also includes Supplementary References.
Data Supplement from BMP4 Inhibits Breast Cancer Metastasis by Blocking Myeloid-Derived Suppressor Cell Activity
Authors: Cao Yuan , Slaney Clare Y. , Bidwell Bradley N. , Parker Belinda S. , Johnstone Cameron N. , Rautela Jai , Eckhardt Bedrich L. , Anderson Robin L.
Published: April 2023

Supplementary Figure 5. BMP4 responsiveness of myeloid cells and MDSC.
Supplementary Methods and Figure Legend from Loss of Androgen Receptor Expression Promotes a Stem-like Cell Phenotype in Prostate Cancer through STAT3 Signaling
Authors: Schroeder Anne , Herrmann Andreas , Cherryholmes Gregory , Kowolik Claudia , Buettner Ralf , Pal Sumanta , Yu Hua , Müller-Newen Gerhard , Jove Richard
Published: April 2023

PDF file - 112K
Supplementary Figure 3 from Loss of Androgen Receptor Expression Promotes a Stem-like Cell Phenotype in Prostate Cancer through STAT3 Signaling
Authors: Schroeder Anne , Herrmann Andreas , Cherryholmes Gregory , Kowolik Claudia , Buettner Ralf , Pal Sumanta , Yu Hua , Müller-Newen Gerhard , Jove Richard
Published: April 2023

PDF file - 2401K, Supplementary Fig. 3: Characterization of recombinant IL-6RFP.
Supplementary Figure 4 from Apoptosis Imaging for Monitoring DR5 Antibody Accumulation and Pharmacodynamics in Brain Tumors Noninvasively
Authors: Weber Thomas G. , Osl Franz , Renner Anja , Pöschinger Thomas , Galbán Stefanie , Rehemtulla Alnawaz , Scheuer Werner
Published: April 2023

PDF file - 186KB, Supplementary Figure 4 - Antibody penetration is enhanced in U87-Luc and U251 brain xenograft tumors indicating BBB disruption.
Supplementary Figure 1, Table 1 from Identification of FoxR2 as an Oncogene in Medulloblastoma
Authors: Koso Hideto , Tsuhako Asano , Lyons Eli , Ward Jerrold M. , Rust Alistair G. , Adams David J. , Jenkins Nancy A. , Copeland Neal G. , Watanabe Sumiko
Published: April 2023

PDF file - 574K, Supplementary Figure S1. Expression of GLI1, FOXR2, TGIF2 and ALX4 in human MBs and cancer cell lines. Supplementary Table S1: Primers used in the study.
Supplemental Figure 2 from MYCN-Dependent Expression of Sulfatase-2 Regulates Neuroblastoma Cell Survival
Authors: Solari Valeria , Borriello Lucia , Turcatel Gianluca , Shimada Hiroyuki , Sposto Richard , Fernandez G. Esteban , Asgharzadeh Shahab , Yates Edwin A. , Turnbull Jeremy E. , DeClerck Yves A.
Published: April 2023

Negative control for figure 2.
Supplementary Figure 5 from Extracellular Vesicles Modulate the Glioblastoma Microenvironment via a Tumor Suppression Signaling Network Directed by miR-1
Authors: Bronisz Agnieszka , Wang Yan , Nowicki Michal O. , Peruzzi Pierpaolo , Ansari Khairul I. , Ogawa Daisuke , Balaj Leonora , De Rienzo Gianluca , Mineo Marco , Nakano Ichiro , Ostrowski Michael C. , Hochberg Fred , Weissleder Ralph , Lawler Sean E. , Chiocca E. Antonio , Godlewski Jakub
Published: April 2023

PDF file - 133K, FIGURE S5 related to FIGURE 6. Effect of miR-1 on GBM-derived EVs protein cargo.
Supplementary Figures 1 - 4 from p53 and NF-κB Coregulate Proinflammatory Gene Responses in Human Macrophages
Authors: Lowe Julie M. , Menendez Daniel , Bushel Pierre R. , Shatz Maria , Kirk Erin L. , Troester Melissa A. , Garantziotis Stavros , Fessler Michael B. , Resnick Michael A.
Published: April 2023

PDF file - 249K, Figure S1. p53 activation by Nutlin-3 induces pro-inflammatory genes. Figure S2. NF-kB plays a role in gene regulation induced by Nutlin-3. Figure S3. Microarray analysis Nutlin-3 and LPS-treated macrophages identifies chemokine genes. Figure S4. p53 is activated in TCMs.
Supplementary Figure Legends from p53 and NF-κB Coregulate Proinflammatory Gene Responses in Human Macrophages
Authors: Lowe Julie M. , Menendez Daniel , Bushel Pierre R. , Shatz Maria , Kirk Erin L. , Troester Melissa A. , Garantziotis Stavros , Fessler Michael B. , Resnick Michael A.
Published: April 2023

PDF file - 41K
Data Supplement from AR-Regulated TWEAK-FN14 Pathway Promotes Prostate Cancer Bone Metastasis
Authors: Yin JuanJuan , Liu Yen-Nien , Tillman Heather , Barrett Ben , Hewitt Stephen , Ylaya Kris , Fang Lei , Lake Ross , Corey Eva , Morrissey Colm , Vessella Robert , Kelly Kathleen
Published: April 2023

Supplemental Table 1. PCR primers. Supplemental Table 2. IHC conditions for TMA samples. Supplemental Table 3. Primary antibodies used in western blot analysis.
Data Supplement from AR-Regulated TWEAK-FN14 Pathway Promotes Prostate Cancer Bone Metastasis
Authors: Yin JuanJuan , Liu Yen-Nien , Tillman Heather , Barrett Ben , Hewitt Stephen , Ylaya Kris , Fang Lei , Lake Ross , Corey Eva , Morrissey Colm , Vessella Robert , Kelly Kathleen
Published: April 2023

Supplemental Figure 1.(A) In vitro growth assay for DU145/RasB1 and DU145/RasB1Fn14shRNA cell lines. (B) Average body weight of mice bearing DU145/RasB1 tumors (n= 9mice) or DU145/RasB1Fn14shRNA tumors over time after tumor cell inoculation (shRNA1, n=10 mice; shRNA2, n=10 mice). * p<0.05 vs EV. (C) Average BLI signal in brain metastasis in mice bearing DU145/RasB1/EV, or DU145/RasB1Fn14shRNA tumor at week 4. *** p<0.001 vs control (D) In vitro growth rate of PC3/EV cells and PC3/Fn14shRNA cell lines. (E) Average BLI signal in bone metastasis per mouse in mice bearing PC3/EV tumors or PC3/Fn14shRNA tumors at week 4. Numbers represent mice with bone metastasis over total mice tested. *p<0.05, **p<0.01 vs EV. (F) Survival curve of mice bearing PC3/EV or two PC3/Fn14shRNA cell lines.**p<0.01 vs EV.
Data Supplement from AR-Regulated TWEAK-FN14 Pathway Promotes Prostate Cancer Bone Metastasis
Authors: Yin JuanJuan , Liu Yen-Nien , Tillman Heather , Barrett Ben , Hewitt Stephen , Ylaya Kris , Fang Lei , Lake Ross , Corey Eva , Morrissey Colm , Vessella Robert , Kelly Kathleen
Published: April 2023

Supplemental Figure 4. (A) AR activity signature genes expressed as a summed Z score in metastatic samples separated on the basis of Fn14 expression above the median (Fn14 high) or below the median (Fn14 low) using the Grasso dataset. * p<0.05. (B) qChIP analysis was performed in DU145 cells expressing doxycycline induced AR. AR binding to the predicted AREs in the Fn14 promoter was determined either with or without prior DHT (5nM) treatment for 4 hours. The binding activity to each site is given as a percentage of total input then normalized to individual immunoglobulin G (IgG). (C) FACS analysis of human Fn14 promoter reporter in DU145 cells expressing Tet-on TA and TREG3-AR with or without prior doxycycline and DHT treatment.
Supplementary Methods from Tumor-Derived GM-CSF Promotes Inflammatory Colon Carcinogenesis via Stimulating Epithelial Release of VEGF
Authors: Wang Yi , Han Gencheng , Wang Ke , Liu Guijun , Wang Renxi , Xiao He , Li Xinying , Hou Chunmei , Shen Beifen , Guo Renfeng , Li Yan , Chen Guojiang
Published: April 2023

PDF file - 154K
Supplementary Figure 4 from Phosphorylation at Ser-181 of Oncogenic KRAS Is Required for Tumor Growth
Authors: Barceló Carles , Paco Noelia , Morell Mireia , Alvarez-Moya Blanca , Bota-Rabassedas Neus , Jaumot Montserrat , Vilardell Felip , Capella Gabriel , Agell Neus
Published: April 2023

PDF file - 31K, Fig. S4. Treatment with PKC inhibitor Edelfosine inhibits tumor growth of HAKRASG12V in a Ser181 KRAS phosphorylation-dependent fashion.