bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of Cardiac Imaging Modalities in the Evaluation of COVID-19-Related Cardiomyopathy
Authors: Cecchetto Antonella , Nistri Stefano , Baroni Giulia , Torreggiani Gianpaolo , Aruta Patrizia , Pergola Valeria , Baritussio Anna , Previtero Marco , Palermo Chiara , Iliceto Sabino , Mele Donato
Published: April 2022

Cardiac involvement has been described during the course of SARS-CoV-2 disease (COVID-19), with different manifestations. Several series have reported only increased cardiac troponin without ventricular dysfunction, others the acute development of left or right ventricular dysfunction, and others myocarditis. Ventricular dysfunction can be of varying degrees and may recover completely in some cases. Generally, conventional echocardiography is used as a first approach to evaluate cardiac dysfunction in patients with COVID-19, but, in some cases, this approach may be silent and more advanced cardiac imaging techniques, such as myocardial strain imaging or cardiac magnetic resonance, are necessary to document alterations in cardiac structure or function. In this review we sought to discuss the information provided by different cardiac imaging techniques in patients with COVID-19, both in the acute phase of the disease and after discharge from hospital, and their diagnostic and prognostic role. We also aimed at verifying whether a specific form of cardiac disease due to the SARS-CoV-2 can be identified.
Features of Extrinsic Plantar Muscles in Patients with Plantar Fasciitis by Ultrasound Imaging: A Retrospective Case Control Research
Authors: Canosa-Carro Lorena , López-López Daniel , García-Sanz Fernando , Díaz-Meco-Conde Raquel , García-Bermejo Paula , de-la-Cruz-Torres Blanca , Marszalek Jolanta , Romero-Morales Carlos
Published: April 2022

The present study aimed to compare by ultrasound imaging (USI) the tibial posterior (TP), medial gastrocnemius (MG) and soleus muscle in patients with and without plantar fasciitis (PF). A sample of 42 individuals was recruited and divided into two groups: PF and a healthy group. The thickness, cross-sectional area (CSA), echointensity and echovariation were assessed in both groups by USI. TP, soleus and MG variables did not report differences (p > 0.05) for thickness and CSA. For the echotexture parameters significant differences were found for MG echointensity (p = 0.002), MG echovariation (p = 0.002) and soleus echointensity (p = 0.012). Non-significant differences (p > 0.05) were reported for soleus echovariation, TP echointensity and TP echovariation variables. The thickness and CSA of the TP, GM and soleus muscle did not show significant differences between individuals with and without PF measured by USI. Muscle quality assessment reported an increase of the MG echointensity and echovariation, as well as a decrease of echointensity of the soleus muscle in the PF group with respect to the healthy group. Therefore, the evaluation of the structure and muscle quality of the extrinsic foot muscles may be beneficial for the diagnosis and monitoring the physical therapy interventions.
Thermal Abuse Tests on 18650 Li-Ion Cells Using a Cone Calorimeter and Cell Residues Analysis
Authors: Mele Maria Luisa , Bracciale Maria Paola , Ubaldi Sofia , Santarelli Maria Laura , Mazzaro Michele , Di Bari Cinzia , Russo Paola
Published: April 2022

Lithium-ion batteries (LIBs) are employed when high energy and power density are required. However, under electrical, mechanical, or thermal abuse conditions a thermal runaway can occur resulting in an uncontrollable increase in pressure and temperature that can lead to fire and/or explosion, and projection of fragments. In this work, the behavior of LIBs under thermal abuse conditions is analyzed. To this purpose, tests on NCA 18,650 cells are performed in a cone calorimeter by changing the radiative heat flux of the conical heater and the State of Charge (SoC) of the cells from full charge to deep discharge. The dependence of SoC and radiative heat flux on the thermal runaway onset is clearly revealed. In particular, a deep discharge determines an earlier thermal runaway of the cell with respect to those at 50% and 100% of SoC when exposed to high radiative heat flux (50 kW/m2). This is due to a mechanism such as an electrical abuse. Cell components before and after tests are investigated using Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy—Energy Dispersive X-ray Spectroscopy (SEM-EDS) and X-ray Diffraction (XRD) to determine the structural, morphological, and compositional changes. It results that the first reaction (423–443 K) that occurs at the anode involves the decomposition of the electrolyte. This reaction justifies the observed earlier venting and thermal runaway of fully charged cells with respect to half-charged ones due to a greater availability of lithium which allows a faster kinetics of the reaction. In the cathode residues, metallic nickel and NO are found, given by decomposition of metal oxide by the rock-salt phase cathode.
The Idea of RFIDtex Transponders Utilization in Household Appliances on the Example of a Washing Machine Demonstrator
Authors: Pawłowicz Bartosz , Kołcz Marek , Jankowski-Mihułowicz Piotr
Published: April 2022

Modern textronic RFID transponders offer a lot of new possibilities for household appliances designers. Possibility to implement new functions is most evident in clothes washing and ironing techniques, where the information stored in the memory of the RFID transponder sewn into the textiles can be used to choose the most appropriate ironing program for a given type of fabric or to select the best washing program for different clothes placed in a drum of washing machine. The purpose of the work was to propose, design, and develop a laboratory stand to demonstrate usage of RFIDtex transponders in a washing machine. The developed device enabled simulation of the presence of textiles equipped with RFIDtex transponders in a washing machine drum. A set of measurements of the constructed device readout efficiency of textronic transponders placed in the drum was also performed. The device firmware, which manages multiple data readings from tags inside the drum for the performed by integrated RWD (read/write device), was also prepared and implemented. This allowed the efficiency of the identification of textiles equipped with RFIDtex transponders to be increased. RFIDtex transponders can also be used in the future to provide precise information about textiles to the washing machine. Based on this information, device will be able to reduce power consumption.
Energy Cell Simulation for Sector Coupling with Power-to-Methane: A Case Study in Lower Bavaria
Authors: Bauer Robert , Schopf Dominik , Klaus Grégoire , Brotsack Raimund , Valdes Javier
Published: April 2022

In this study, the possibility of sector coupling with biological Power-to-Methane to support and stabilize the energy transition of the three major sectors of electricity, heat, and gas was addressed. For this purpose, the energy cell simulation methodology and the Calliope tool were utilized for energy system optimization. This combination provides detailed insights into the existing dependencies of consumers and fossil and renewable energy suppliers on a local scale. In this context, Power-to-Methane represents an efficient technology for quickly and effectively exploiting unused electricity potential for various sectors and consumers. It was found that, even in regions with low wind levels, this surplus electricity potential already exists and depends on various influencing factors in very different ways. The solar influence on these potentials was considered in connection with gas-fired cogeneration plants for district heating. It was found that the current heat demand for district heating produces a large amount of electricity and can generate surplus electricity in the winter. However, in the summer, large amounts of usable waste heat are dissipated into the environment, owing to the low consumption of district heat. This problem in the heat sector could be reduced by the expansion of photovoltaics, but this would require further expansion of storage or conversion systems in the electricity sector. This demonstrates that the consideration of several sectors is necessary to reflect the complexity of the sector coupling with Power-to-Methane properly.
Research on TVD Control of Cornering Energy Consumption for Distributed Drive Electric Vehicles Based on PMP
Authors: Sun Wen , Chen Yang , Wang Junnian , Wang Xiangyu , Liu Lili
Published: April 2022

This paper aims to study the torque optimization control of distributed drive electric vehicles in the cornering process and reduce the cornering energy consumption. The main energy consumption of the vehicle in the cornering process is analyzed clearly based on the 7-DOF vehicle dynamics model. The torque vectoring distribution (TVD) of a distributed drive electric vehicle in the process of turning was studied on the basis of the Pontryagin Minimum Principle (PMP). The Beetle Antenna Search–Particle Swarm Optimization (BAS-PSO) algorithm was used to optimize the torque distribution coefficient offline, and the algorithm was improved to improve the operation speed. Based on the vehicle dynamics characteristics, the table of torque distribution coefficient of minimum turning energy consumption and the optimal energy-saving degree of TVD control in different bending conditions were worked out.
Effects of Bulk Flow Pulsation on Film Cooling Involving Compound Angle
Authors: Baek Seung-Il , Ahn Joon
Published: April 2022

The main flow could be unsteady in flow fields of film cooling for several reasons such as flow interactions between the rotor and the stator in the turbine. Understanding the characteristics of the film-cooling flow with an unsteady flow is important in the design of gas turbines. The effects of 36-Hz pulsations in the main flow on the streamwise velocity distributions, turbulence statistics, and temperature fluctuations in the film-cooling flow from a cylindrical hole with an orientation angle are investigated by numerical methods. Large-eddy simulation (LES) results match the experimental data with an acceptable accuracy, whereas the Reynolds-averaged Navier–Stokes simulation (RANS) results show large deviations with the experimental data and the LES results. Under 36-Hz pulsations, the URANS results predict a weaker streamwise velocity of the coolant jet that blocks the main flow compared with the LES. With 36-Hz pulsations at the time-averaged blowing ratio of 0.5, urms, the root mean squared fluctuating velocity in the streamwise direction around the coolant core increased due to intensive mixing, and vrms, the root mean squared fluctuating velocity in the wall-normal direction, increased along the trajectory of the injected coolant. Moreover, wrms, the root mean squared fluctuating velocity in the spanwise direction, increased around the wall compared to those at a steady state. The dimensionless temperature fluctuations increased in the region of the core of the coolant compared with those at a steady state. When the orientation angle was 30°, the distribution of the results moved in the z-direction; however, the overall trend was similar to that of a simple angle.
Genetic Analysis of the Grapevine GATA Gene Family and Their Expression Profiles in Response to Hormone and Downy Mildew Infection
Authors: Chen Tingting , Peng Jing , Li Meijie , Dou Mengru , Lei Yan , Wang Yuejing , Xu Yan
Published: April 2022

Grapevine (Vitis. vinifera L.) is one of the most economically important fruit crops throughout the world. However, grape production is increasingly impacted by numerous diseases, including downy mildew, caused by the oomycete Plasmopara viticola. In grapevine and other plants, members of the GATA family of transcription factors play key roles in light and phytohormone signaling. However, little is known about their potential roles in biotic defense responses. As a first step, we identified 27 GATA transcription factors in grapevine and defined their transcriptional responses to three biotic stress-related phytohormones (SA, MeJA, and BR) in callus cells, and challenge with P. viticola in a downy mildew-sensitive cultivar, V. vinifera ‘Pinot noir’, and a resistant cultivar, V. piasezkii ‘Liuba-8′. Many of the VvGATA genes had higher expression at 0.5 h after hormones treatments. Moreover, a group of VvGATAs was dramatically induced in ‘Liuba-8′ at 24 post infection by P. viticola. However, the same genes were significantly repressed and showed low expression levels in ‘Pinot noir’. Additionally, VvGATA27 was located in the nucleus and had transcriptional activity. Taken together, the study identified the GATA full gene families in grapes on phylogenetic analysis and protein structure. Moreover, this study provided a basis for discussing the roles of VvGATAs in response to hormones and P. viticola infection. Our results provided evidence for the selection of candidate genes against downy mildew and lay the foundation for further investigation of VvGATA transcription factors.
Estimation of the Seasonal Inhaled Deposited Dose of Particulate Matter in the Respiratory System of Urban Individuals Living in an Eastern Mediterranean City
Authors: Hussein Tareq , Al-Abdallat Asal , Saleh Shatha Suleiman Ali , Al-Kloub Marwan
Published: April 2022

In this study, we present an estimation for the inhaled deposited dose rate in adult males and females during common exposure scenarios to urban background aerosols in an Eastern Mediterranean city (Amman, Jordan) based on a one-year database of measured particle number size distribution. The dose rates show seasonal variations reflecting the physical characteristics (i.e., modal structure) of the particle number size distribution. An additional factor was the varying deposition fraction (DF) for different regions and different human activities (exercising versus resting). The total dose rate was 3 × 109–65 × 109 particles/h (PM2.5 and PM10 doses 1–22 µg/h and 9–210 µg/h; respectively) depending on the gender, activity, and season. Based on the particle number metrics, the inhaled deposited dose in the head, Tracheobronchial, and alveolar were 7–16%, 16–28%, and 56–76%; respectively. Based on the PM2.5 metric, the corresponding dose rate was 9–41%,13–19%; and 46–72% respectively. As for the PM10 metric, they were 25–75%, 7–35%, and 15–55%; respectively.
Enhancing Parents’ Well-Being after Preterm Birth—A Qualitative Evaluation of the “Transition to Home” Model of Care
Authors: Schuetz Haemmerli Natascha , Stoffel Liliane , Schmitt Kai-Uwe , Khan Jeannine , Humpl Tilman , Nelle Mathias , Cignacco Eva
Published: April 2022

There are few programs available aimed at preventing short- and long-term negative consequences after preterm birth and covering the entire care continuum. The “Transition to Home (TtH)” model is such a program, offering structured, individual support for families with preterm infants before and after hospital discharge. This study gathers and examines the parents’ views of receiving support from an interprofessional team under the TtH model of care during hospitalization and after discharge. Using a qualitative explorative design, 39 semi-structured interviews with parents were analyzed thematically. From this analysis, three main themes were identified: (1) TtH and the relevance of continuity of care; (2) Enhancement of parents’ autonomy and self-confidence; (3) Perception of interprofessional collaboration. Within these themes, the most relevant aspects identified were continuity of care and the appointment of a designated health care professional to anchor the entire care continuum. Emotional support complemented by non-medical approaches, along with strength-based and family resource-oriented communication, also emerged as key aspects. Continuous, family-centered care and well-organized interprofessional collaboration promote the well-being of the family after a premature birth. If the aspects identified in this study are applied, the transition from hospital to home will be smoothened for the benefit of affected families.
Chronic Effects of Foam Rolling on Flexibility and Performance: A Systematic Review of Randomized Controlled Trials
Authors: Pagaduan Jeffrey Cayaban , Chang Sheng-Yuan , Chang Nai-Jen
Published: April 2022

The purpose of this study is to review the existing literature on chronic effects of foam rolling (FR) on flexibility and performance. Electronic databases were searched during January 2022 for topics related to FR. Included studies met the following criteria: (a) peer-reviewed articles written in English; (b) FR intervention of at least four weeks; (c) non-motorized FR device during intervention; (d) randomized controlled trial with existence of a control group; and (e) any lower body parameter related to flexibility, recovery, and performance. Nine studies met that criteria. Results revealed that chronic FR demonstrated conflicting results for improvement of flexibility. On the other hand, a majority of the articles in this review showed no beneficial effects of FR on performance. Lastly, the effect of FR on recovery is unclear. These findings suggest the need for further studies to establish the consensus about the long-term application of FR in flexibility, recovery, and performance.
Culture Isolate of Rickettsia felis from a Tick
Authors: Danchenko Monika , Benada Oldřich , Škultéty Ľudovít , Sekeyová Zuzana
Published: April 2022

Although the cat flea, Ctenocephalides felis, has been identified as the primary vector of Rickettsia felis, additional flea, tick, mite, and louse species have also been associated with this bacterium by molecular means; however, the role of these arthropods in the transmission of R. felis has not been clarified. Here, we succeeded in culture isolation of R. felis from a host-seeking castor bean tick, Ixodes ricinus, the most common tick in Slovakia. The bacterial isolation was performed on XTC-2 cells at 28 °C using the shell-vial technique. An evaluation of the growth properties was performed for both the XTC-2 and Vero cell lines. We observed R. felis in the infected host cells microscopically by Gimenez staining and immunofluorescence assay. The R. felis isolate was purified by gradient ultracentrifugation and visualized by electron microscopy. Fragments of the genes gltA, ompA, ompB, htrA, rpoB, sca4, rffE, and rrs were amplified and compared with the corresponding sequences of the type strain URRWXCal2 and other R. felis culture -isolated strains. We did not detect any nucleotide polymorphisms; however, plasmid pRFδ, characteristic of the standard strain, was absent in our isolate. Herein, we describe the first successful isolation and characterization of a tick-derived R. felis strain “Danube”, obtained from an I. ricinus nymph.
What Affects Emotional Well-Being during Travel? Identifying the Factors by Maximal Information Coefficient
Authors: Ma Yongfeng , Chen Shuyan , Khattak Aemal J. , Cao Zheng , Zubair Muhammad , Han Xue , Hu Xiaojian
Published: April 2022

Traveler emotional well-being as a specific domain of subjective well-being has attracted attention across the field of transportation. Studies on identifying factors of travel-related emotional well-being can help policy makers to formulate concrete strategies to improve travelers’ experiences and public health. This research used the Maximal Information Coefficient (MIC) to select important factors which have much influence on emotional well-being during travel. American Time Use Survey data collected in 2010, 2012, and 2013 were used in this study and 10 factors have been selected to illustrate the relationship with emotional well-being, including rest, weekly earnings, activity time for well-being, health, self-evaluation of activities, pain medication taken yesterday, travel purpose, travel duration, weekly working hours and age based on MIC values in Descending sort. Among these 10 selected features, 2 factors, travel purpose and travel duration, are related to travel contexts; the other factors are related to personal and social characteristics. It is found that an individual’s physical condition and self-evaluation of activities have much influence on travel-related emotional well-being, while traveling mode and interaction during travel have a relatively small impact on emotional well-being compared to other identified factors. This finding is different from previous research findings. The paper presents traffic strategies related to improving emotional well-being of travelers while traveling based on the findings from this research.
Live Intraoral Dirofilaria repens of Lower Lip Mimicking Mucocele—First Reported Case from Croatia
Authors: Skrinjar Ivana , Brailo Vlaho , Loncar Brzak Bozana , Lozic Erent Jelena , Bukovski Suzana , Juras Danica Vidovic
Published: April 2022

Dirofilariasis is an endemic infestation in tropical and subtropical countries caused by about 40 different species. It rarely occurs in the oral cavity and is mostly presented as mucosal and submucosal nodules. Differential diagnoses include lipoma, mucocele, and pleomorphic adenoma. We report a rare case of oral dirofilariasis mimicking mucocele in a 41-year-old male patient from Croatia without an epidemiological history of travelling outside the country. He came in because of non-painful lower lip swelling that had lasted for two months. The parasite was surgically removed from the lesion. This is the first reported case of oral dirofilariasis in Croatia. It is important to point out this rare diagnosis in order to make dentists aware of the possibility of the presence of such an infestation in common lesions of the oral mucosa.
Activity of ALK Inhibitors in Renal Cancer with ALK Alterations: A Systematic Review
Authors: Iannantuono Giovanni Maria , Riondino Silvia , Sganga Stefano , Roselli Mario , Torino Francesco
Published: April 2022

Renal cell carcinoma (RCC) associated with anaplastic lymphoma kinase (ALK) gene rearrangements (ALK-RCC) is currently considered an “emerging or provisional” tumor entity by the last World Health Organization classification published in 2016. Although several studies assessing ALK-RCC’s clinical and histological characteristics have been published in recent years, only a few publications have evaluated the activity of ALK inhibitors (ALK-i) in this subgroup of patients. Considering the well-recognized efficacy of this evolving class of targeted therapies in other ALK-positive tumors, we conducted a systematic review to evaluate the reported activity of ALK-i in the ALK-RCC subtype. MEDLINE was searched from its inception to 7 January 2022 for case reports and case series on adult metastatic ALK-RCC patients treated with ALK-i whose therapeutic outcomes were available. A virtual cohort of ALK-RCC patients was created. Our results showed a favorable activity of first- and second-generation ALK-i in pretreated ALK-RCC patients in terms of either radiological response or performance status improvement. We hope that the present work will prompt the creation of large, multi-institutional clinical trials to confirm these promising early data.
Circulating microRNAs in Medicine
Authors: Pozniak Tetiana , Shcharbin Dzmitry , Bryszewska Maria
Published: April 2022

Circulating microRNAs (c-microRNAs, c-miRNAs), which are present in almost all biological fluids, are promising sensitive biomarkers for various diseases (oncological and cardiovascular diseases, neurodegenerative pathologies, etc.), and their signatures accurately reflect the state of the body. Studies of the expression of microRNA markers show that they can enable a wide range of diseases to be diagnosed before clinical symptoms are manifested, and they can help to assess a patient’s response to therapy in order to correct and personalize treatments. This review discusses the latest trends in the uses of miRNAs for diagnosing and treating various diseases, viral and non-viral. It is concluded that exogenous microRNAs can be used as high-precision therapeutic agents for these purposes.
Cyto-Genotoxic and Transcriptomic Alterations in Human Liver Cells by Tris (2-Ethylhexyl) Phosphate (TEHP): A Putative Hepatocarcinogen
Authors: Saquib Quaiser , Al-Salem Abdullah M. , Siddiqui Maqsood A. , Ansari Sabiha M. , Zhang Xiaowei , Al-Khedhairy Abdulaziz A.
Published: April 2022

Tris (2-ethylhexyl) phosphate (TEHP) is an organophosphate flame retardant (OPFRs) which is extensively used as a plasticizer and has been detected in human body fluids. Contemporarily, toxicological studies on TEHP in human cells are very limited and there are few studies on its genotoxicity and cell death mechanism in human liver cells (HepG2). Herein, we find that HepG2 cells exposed to TEHP (100, 200, 400 µM) for 72 h reduced cell survival to 19.68%, 49.83%, 58.91% and 29.08%, 47.7% and 57.90%, measured by MTT and NRU assays. TEHP did not induce cytotoxicity at lower concentrations (5, 10, 25, 50 µM) after 24 h and 48 h of exposure. Flow cytometric analysis of TEHP-treated cells elevated intracellular reactive oxygen species (ROS), nitric oxide (NO), Ca++ influx and esterase levels, leading to mitochondrial dysfunction (ΔΨm). DNA damage analysis by comet assay showed 4.67, 9.35, 13.78-fold greater OTM values in TEHP (100, 200, 400 µM)-treated cells. Cell cycle analysis exhibited 23.1%, 29.6%, and 50.8% of cells in SubG1 apoptotic phase after TEHP (100, 200 and 400 μM) treatment. Immunofluorescence data affirmed the activation of P53, caspase 3 and 9 proteins in TEHP-treated cells. In qPCR array of 84 genes, HepG2 cells treated with TEHP (100 µM, 72 h) upregulated 10 genes and downregulated 4 genes belonging to a human cancer pathway. Our novel data categorically indicate that TEHP is an oxidative stressor and carcinogenic entity, which exaggerates mitochondrial functions to induce cyto- and genotoxicity and cell death, implying its hepatotoxic features.
A Review of the Recent Developments of Molecular Hybrids Targeting Tubulin Polymerization
Authors: Ebenezer Oluwakemi , Shapi Michael , Tuszynski Jack A.
Published: April 2022

Microtubules are cylindrical protein polymers formed from αβ-tubulin heterodimers in the cytoplasm of eukaryotic cells. Microtubule disturbance may cause cell cycle arrest in the G2/M phase, and anomalous mitotic spindles will form. Microtubules are an important target for cancer drug action because of their critical role in mitosis. Several microtubule-targeting agents with vast therapeutic advantages have been developed, but they often lead to multidrug resistance and adverse side effects. Thus, single-target therapy has drawbacks in the effective control of tubulin polymerization. Molecular hybridization, based on the amalgamation of two or more pharmacophores of bioactive conjugates to engender a single molecular structure with enhanced pharmacokinetics and biological activity, compared to their parent molecules, has recently become a promising approach in drug development. The practical application of combined active scaffolds targeting tubulin polymerization inhibitors has been corroborated in the past few years. Meanwhile, different designs and syntheses of novel anti-tubulin hybrids have been broadly studied, illustrated, and detailed in the literature. This review describes various molecular hybrids with their reported structural–activity relationships (SARs) where it is possible in an effort to generate efficacious tubulin polymerization inhibitors. The aim is to create a platform on which new active scaffolds can be modeled for improved tubulin polymerization inhibitory potency and hence, the development of new therapeutic agents against cancer.
Sunitinib and Pterostilbene Combination Treatment Exerts Antitumor Effects in Gastric Cancer via Suppression of PDZD8
Authors: Hojo Yudai , Kishi Shingo , Mori Shiori , Fujiwara-Tani Rina , Sasaki Takamitsu , Fujii Kiyomu , Nishiguchi Yukiko , Nakashima Chie , Luo Yi , Shinohara Hisashi , Kuniyasu Hiroki
Published: April 2022

The use of molecular-targeted drugs in the treatment of gastric cancer is increasing. However, the variety of molecular-targeted drugs in gastric cancer is still limited, and the development of new molecular-targeted therapies is required. The effect of combining sunitinib (SUN) with pterostilbene (PTE) on the human gastric cancer cell lines TMK1 and MKN74 was examined in in vitro and in vivo. Compared with SUN or PTE treatment alone, cotreatment induced pronounced suppression of cell proliferation, with a marked increase in oxidative stress. SUN was associated with a significant retention of mitochondrial Fe2+. SUN-treated cells decreased expression of PDZ domain-containing protein 8 (PDZD8). Knockdown of PDZD8 in both cells induced Fe2+ retention, and siPDZD8+PTE markedly suppressed cell proliferation with suppressed oxidative phosphorylation, as did the combination of SUN+PTE. In a nude mouse tumor model, a pronounced antitumor effect was observed with SUN+PTE treatment compared to SUN alone. PDZD8 may be a newly discovered off-target for SUN, and that the combined use of PTE with SUN significantly promotes antitumor activity in gastric cancer cell lines. The combined use of SUN and PTE might be a new molecular-targeted therapy for gastric cancer.
A Rheostat of Ceramide and Sphingosine-1-Phosphate as a Determinant of Oxidative Stress-Mediated Kidney Injury
Authors: Ueda Norishi
Published: April 2022

Reactive oxygen species (ROS) modulate sphingolipid metabolism, including enzymes that generate ceramide and sphingosine-1-phosphate (S1P), and a ROS-antioxidant rheostat determines the metabolism of ceramide-S1P. ROS induce ceramide production by activating ceramide-producing enzymes, leading to apoptosis, while they inhibit S1P production, which promotes survival by suppressing sphingosine kinases (SphKs). A ceramide-S1P rheostat regulates ROS-induced mitochondrial dysfunction, apoptotic/anti-apoptotic Bcl-2 family proteins and signaling pathways, leading to apoptosis, survival, cell proliferation, inflammation and fibrosis in the kidney. Ceramide inhibits the mitochondrial respiration chain and induces ceramide channel formation and the closure of voltage-dependent anion channels, leading to mitochondrial dysfunction, altered Bcl-2 family protein expression, ROS generation and disturbed calcium homeostasis. This activates ceramide-induced signaling pathways, leading to apoptosis. These events are mitigated by S1P/S1P receptors (S1PRs) that restore mitochondrial function and activate signaling pathways. SphK1 promotes survival and cell proliferation and inhibits inflammation, while SphK2 has the opposite effect. However, both SphK1 and SphK2 promote fibrosis. Thus, a ceramide-SphKs/S1P rheostat modulates oxidant-induced kidney injury by affecting mitochondrial function, ROS production, Bcl-2 family proteins, calcium homeostasis and their downstream signaling pathways. This review will summarize the current evidence for a role of interaction between ROS-antioxidants and ceramide-SphKs/S1P and of a ceramide-SphKs/S1P rheostat in the regulation of oxidative stress-mediated kidney diseases.
The Effects of TNF-α Inhibition on the Metabolism of Cartilage: Relationship between KS, HA, HAPLN1 and ADAMTS4, ADAMTS5, TOS and TGF-β1 Plasma Concentrations in Patients with Juvenile Idiopathic Arthritis
Authors: Kuźnik-Trocha Kornelia , Winsz-Szczotka Katarzyna , Lachór-Motyka Iwona , Dąbkowska Klaudia , Wojdas Magdalena , Olczyk Krystyna , Komosińska-Vassev Katarzyna
Published: April 2022

We assessed the effect of 24-month anti-tumor necrosis factor alpha (TNF-α) treatment on the remodeling of the cartilage extracellular matrix (ECM) in patients with juvenile idiopathic arthritis (JIA). Methods: Quantitative evaluation of keratan sulfate (KS), hyaluronic acid (HA), hyaluronan and proteoglycan link protein 1 (HAPLN1), as potential biomarkers of joint dysfunction, and the levels of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) 4 and 5, total oxidative status (TOS) and transforming growth factor (TGF-β1) was performed (using immunoenzymatic methods) in blood obtained from patients before and after 24 months of etanercept (ETA) treatment. Results: When compared to the controls, KS, HA and HAPLN1 levels were significantly higher in patients with an aggressive course of JIA qualified for ETA treatment. An anti-cytokine therapy leading to clinical improvement promotes the normalization only of the HA level. Proteolytic and pro-oxidative factors, present in high concentrations in patients before the treatment, correlated with HAPLN1, but not with KS and HA levels. In these patients, negative correlations were found between the levels of TGF-β1 and KS, HA and HAPLN1. Conclusion: The anti-TNF-α therapy used in patients with JIA has a beneficial effect on ECM cartilage metabolism, but it does not completely regenerate it. The changes in the plasma HA level during the anti-cytokine therapy suggest its potential diagnostic utility in monitoring of disease activity and may be used to assess the efficacy of ETA treatment.
Numerical Study of Topographic Effects on Wind-Driven Coastal Upwelling on the Scotian Shelf
Authors: Shan Shiliang , Sheng Jinyu
Published: April 2022

Wind-driven coastal upwelling can cause a sudden drop in sea surface temperatures (SSTs) of up to more than 8 °C on the inner Scotian Shelf (ScS) in the summer months. Three major coastal upwelling events on the ScS in the summer of 2012 are analyzed using in-situ SST observations and satellite remote sensing SST data. A spatial correlation analysis of satellite SST data shows an asymmetric distribution in the along-shore direction with smaller correlation coefficients in the downstream area than in the upstream area over the inner ScS during upwelling events. A regression analysis indicates that the wind impulse plays a major role in generating the SST cooling during the initial response stage of upwelling events. A nested-grid ocean circulation model (DalCoast-CSS) is used to examine the effect of irregular coastline and rugged bathymetry on the spatial and temporal variability of wind-driven upwelling over the inner ScS. The model has four submodels downscaling from the eastern Canadian Shelf to the central ScS. The model external forcing includes tides, winds, river discharges, and net heat flux at the sea surface. A comparison of model results with the satellite SST data reveals a satisfactory performance of the model in reproducing the development of coastal upwelling on the ScS. Model results demonstrate that the irregular coastline and rugged bathymetry play important roles in influencing the temporal and spatial evolution of the upwelling plume over the inner ScS. The irregular coastline (e.g., cape) is responsible for the relatively warm SSTs in two downstream inlets (i.e., St. Margarets Bay and Mahone Bay) and adjacent coastal waters. The rugged bathymetry (e.g., submerged bank) influences the spatial extent of filaments through the advection process.
Analysis, Simulation and Experimental Study of the Tensile Stress Calibration of Ceramic Cylindrical Pressure Housings
Authors: Wang Peng , Wang Yanhui , Yang Shaoqiong , Niu Wendong , Wang Xuehao , Li Penghao
Published: April 2022

Engineering ceramics have extremely high values for both specific modulus and specific compressive strength, making them one of the most promising materials for enhancing the carrying capability of full ocean depth (FOD) submersibles. However, due to the low tensile strength of most ceramic materials, the tensile stress generated at the contact surface of ceramic pressure housings under hydrostatic pressure may exceed the material’s limits and thus lead to cracking failure. Currently, there are no valid calibration methods for the tensile stress caused by material discontinuities at the contact surface. In this paper, an approximate model is established based on contact mechanics. The absolute error of the approximate model, as verified by the simulation results for nine groups of ceramic pressure housings, does not exceed 14.2%. It is also concluded that the smaller the difference in Young’s modulus between the ceramics and metals, the higher the tensile strength safety factor. In addition, two hydrostatic pressure experiments were carried out to further verify the results of the approximate model and the numerical solutions. The approximate model is oriented to the reliable design of ceramic pressure housings. It will play an important role in improving the carrying capacity and observation capability of FOD submersibles.
Changes in the Mean of and Variance in Psychological Disease Incidences before and during the COVID-19 Pandemic in the Korean Adult Population
Authors: Kim So Young , Yoo Dae Myoung , Kwon Mi-Jung , Kim Ji-Hee , Kim Joo-Hee , Bang Woo-Jin , Choi Hyo Geun
Published: April 2022

The coronavirus disease 2019 (COVID-19) pandemic has been suggested to increase the risk of depression and anxiety disorders. This study expanded upon previous findings by estimating the changes in medical visits for various psychological disorders during the COVID-19 pandemic compared to before COVID-19. The entire Korean population ≥ 20 years old (~42.3 million) was included. The first COVID-19 case in Korea was reported on 20 January 2020. Thus, the period from January 2018 through to February 2020 was classified as “before COVID-19”, and the period from March 2020 through to May 2021 was classified as “during COVID-19”. Monthly medical visits due to the following 13 psychological disorders were evaluated: depressive disorder, bipolar disorder, primary insomnia, schizophrenia, panic disorder, hypochondriasis, posttraumatic stress disorder (PTSD), anxiety disorder, anorexia nervosa, addephagia, alcoholism, nicotine dependency, and gambling addiction were evaluated. The differences in the number of medical visits and the variance of diseases before and during the COVID-19 pandemic were analyzed using the Mann–Whitney U test and Levene’s test. Subgroup analyses were conducted according to age and sex. The frequencies of medical visits for depressive disorder, bipolar disorder, primary insomnia, panic disorder, hypochondriasis, PTSD, anxiety disorder, anorexia nervosa, addephagia, and gambling addiction were higher during COVID-19 than before COVID-19 (all p < 0.001). However, the frequencies of medical visits for schizophrenia, alcoholism, and nicotine dependency were lower during the COVID-19 pandemic than before the COVID-19 pandemic (all p < 0.001). The psychological disorders with a higher frequency of medical visits during COVID-19 were consistent in all age and sex subgroups. In the old age group, the number of medical visits due to schizophrenia was also higher during COVID-19 than before COVID-19 (p < 0.001). Many psychological disorders, including depressive disorder, bipolar disorder, primary insomnia, panic disorder, hypochondriasis, PTSD, anxiety disorder, anorexia nervosa, addephagia, and gambling addiction, had a higher number of related medical visits, while disorders such as schizophrenia, alcoholism, and nicotine dependency had a lower number of related medical visits during COVID-19 among Korean adults.
Flammability and Thermoregulation Properties of Knitted Fabrics as a Potential Candidate for Protective Undergarments
Authors: Stygienė Laimutė , Krauledas Sigitas , Abraitienė Aušra , Varnaitė-Žuravliova Sandra , Dubinskaitė Kristina
Published: April 2022

The most important functional purpose of knitted fabrics used for the protective non-flammable underwear worn in contact with the skin is to ensure wearing comfort by creating and maintaining a constant and pleasant microclimate at the skin surface independently from the environmental conditions. Protective non-flammable underwear may be used by firefighters or sportsmen, e.g., racing (Formula) sportsmen, where a risk of burn injuries (when the car is on fire after a car crash) is present. In order to investigate the flammability and thermal comfort properties of two-layer knitted fabrics, two groups of aramids and flame-retardant (FR) viscose fiber fabrics of different combined patterns and surface structures (porosity and flatness) were designed and manufactured for this research. Aramid fiber spun yarns (METAFINE.X.95®) formed the inner layer (contacting with human skin) of fabrics and aramid/viscose FR fiber spun yarns (METALEN®) formed the outer layer. For the evaluation of the functional characteristics of the manufactured fabrics, the flammability and thermoregulating properties, such as liquid moisture management, water vapor and air permeability, and thermal resistance were investigated. The results show that all tested fabrics are non-flammable, breathable, permeable to air, and can be assigned to moisture management fabrics. Their obtained overall moisture management capacity (OMMC) values are in the range 0.59–0.88. The knitted fabrics with an embossed porous surface to skin had a higher OMMC (0.75–0.88). The thermoregulation comfort properties were mostly influenced by the structure of the fabrics, while the burning behavior was found to be independent from the structure, and the non-flammability properties were imparted by the fiber content of the knits.
The Influence of Low-Molecular-Weight Monomers (TEGDMA, HDDMA, HEMA) on the Properties of Selected Matrices and Composites Based on Bis-GMA and UDMA
Authors: Szczesio-Wlodarczyk Agata , Polikowski Aleksander , Krasowski Michał , Fronczek Magdalena , Sokolowski Jerzy , Bociong Kinga
Published: April 2022

Bisphenol A-glycidyl methacrylate (bis-GMA) and urethane dimethacrylate (UDMA) are usually combined with low-viscosity monomers to obtain more desirable viscosity, handling characteristics and general properties. The present study determined the flexural strength (FS), flexural modulus (FM), diametral tensile strength (DTS), and hardness (HV) of five matrices and composites based on these resins. The polymerization shrinkage stress (PSS) was also studied for the composites. The polymer matrices were formed using bis-GMA and UDMA. TEGDMA, HEMA and HDDMA acted as co-monomers. The composites had 45 wt.% of filler content. The highest FS and FM were obtained from the UDMA/bis-GMA/TEGDMA/HEMA matrix and the composite (matrix + filler). The best DTS values were obtained from the UDMA/bis-GMA/HEMA matrix and the composite. One of the lowest values of FS, FM, and DTS was obtained from the UDMA/bis-GMA/HDDMA matrix and the composite. All the composites demonstrated similar hardness values. The lowest polymerization shrinkage stress was observed for the UDMA/bis-GMA/TEGDMA/HEMA composite, and the highest PSS was observed for the UDMA/bis-GMA/TEGDMA/HDDMA composite. The addition of HEMA had a positive effect on the properties of the tested materials, which may be related to the improved mobility of the bis-GMA and UDMA monomers.
Generalized Hopf–Ore Extensions of Hopf Group-Coalgebras
Authors: Wang Ding-Guo , Wang Xing
Published: April 2022

In this paper, we introduce the concept of a generalized Hopf–Ore extension of a Hopf group-coalgebra and give the necessary and sufficient conditions for the Ore extension of a Hopf group-coalgebra to be a Hopf group-coalgebra. Moreover, an isomorphism theorem on generalized Hopf group-coalgebra Ore extensions is given and specific cases in a simple type called special Hopf group-coalgebra Ore extensions are also considered. Our results are generalizations of Hopf–Ore extensions on Hopf algebras and also are very useful to construct new Hopf group-coalgebras.
Satellites of Functors for Nonassociative Algebras with Metagroup Relations
Authors: Ludkowski Sergey Victor
Published: April 2022

The article is devoted to non-associative algebras with metagroup relations and modules over them. Their functors are studied. Satellites of functors are scrutinized. An exactness of satellite sequences and diagrams is investigated.
GR-GNN: Gated Recursion-Based Graph Neural Network Algorithm
Authors: Ge Kao , Zhao Jian-Qiang , Zhao Yan-Yong
Published: April 2022

Under an internet background involving artificial intelligence and big data—unstructured, materialized, network graph-structured data, such as social networks, knowledge graphs, and compound molecules, have gradually entered into various specific business scenarios. One problem that urgently needs to be solved in the industry involves how to perform feature extractions, transformations, and operations in graph-structured data to solve downstream tasks, such as node classifications and graph classifications in actual business scenarios. Therefore, this paper proposes a gated recursion-based graph neural network (GR-GNN) algorithm to solve tasks such as node depth-dependent feature extractions and node classifications for graph-structured data. The GRU neural network unit was used to complete the node classification task and, thereby, construct the GR-GNN model. In order to verify the accuracy, effectiveness, and superiority of the algorithm on the open datasets Cora, CiteseerX, and PubMed, the algorithm was used to compare the operation results with the classical graph neural network baseline algorithms GCN, GAT, and GraphSAGE, respectively. The experimental results show that, on the validation set, the accuracy and target loss of the GR-GNN algorithm are better than or equal to other baseline algorithms; in terms of algorithm convergence speed, the performance of the GR-GNN algorithm is comparable to that of the GCN algorithm, which is higher than other algorithms. The research results show that the GR-GNN algorithm proposed in this paper has high accuracy and computational efficiency, and very wide application significance.
Integrable Solutions for Gripenberg-Type Equations with m-Product of Fractional Operators and Applications to Initial Value Problems
Authors: Alsaadi Ateq , Cichoń Mieczysław , Metwali Mohamed M. A.
Published: April 2022

In this paper, we deal with the existence of integrable solutions of Gripenberg-type equations with m-product of fractional operators on a half-line R+=[0,∞). We prove the existence of solutions in some weighted spaces of integrable functions, i.e., the so-called L1N-solutions. Because such a space is not a Banach algebra with respect to the pointwise product, we cannot follow the idea of the proof for continuous solutions, and we prefer a fixed point approach concerning the measure of noncompactness to obtain our results. Appropriate measures for this space and some of its subspaces are introduced. We also study the problem of uniqueness of solutions. To achieve our goal, we utilize a generalized Hölder inequality on the noted spaces. Finally, to validate our results, we study the solvability problem for some particularly interesting cases and initial value problems.
Successful Dabrafenib Desensitization Protocols in a Patient with Metastatic Melanoma
Authors: Bumbacea Roxana Silvia , Ali Selda , Corcea Sabina Loredana , Jinga Dan Corneliu , Spiru Luiza
Published: April 2022

Dabrafenib and trametinib are two available molecules that have been approved for the treatment of metastatic melanoma with BRAF-V600E or V600K mutations. Their combined therapy has led to long-lasting survival benefits and substantially improved outcomes. Until now, only a few cases of severe hypersensitivity reactions to dabrafenib and vemurafenib have been reported, and even fewer desensitization protocols to these molecules have been documented. We report the case of a 71-year-old female patient with metastatic melanoma harboring a BRAF-V600E mutation undergoing targeted therapy with dabrafenib and trametinib. Two weeks after the initiation of the combined treatment, she developed a hypersensitivity reaction. The cause–effect relationship between dabrafenib and the hypersensitivity reaction was demonstrated twice, when symptoms recurred upon dabrafenib reintroduction. We started a rapid 3-day dabrafenib desensitization protocol, which was well tolerated. When the patient discontinued the drug administration, we decided on a longer protocol that included more steps and more days in order to prevent the occurrence of other hypersensitivity reactions. Our patient tolerated both rapid and slow-going schedules, the first one reaching the final dose within 3 days and the second one reaching the total daily dose within 14 days. Depending on the patient’s needs, the severity of the hypersensitivity reaction and the hospital’s availability, the doctor may choose either the rapid or slow-going desensitization protocol.