bluuebunny/crossref_metadata_2025 huggingface dataset:
Graft Maturity Assessment by Magnetic Resonance Imaging and its Relation with Functional Scores after Anterior Cruciate Ligament Reconstruction with Hamstring Graft
Authors: Arun G. R. , Rao Manohar , Patil Neelanagowda , Srinivasan Namrata , Krishnan P. Rahul , Deepak M. K. , Sindhu B.
Published: October 2024

Background/Objectives:

Anterior cruciate ligament (ACL) reconstruction is a common procedure performed in orthopedic surgery. There are many methods to evaluate the functional outcome postoperatively, but no single reliable method exists to assess graft maturity. The purpose of this research is to evaluate graft maturity by magnetic resonance imaging (MRI) and its relation with functional outcome at the end of 6 months and 12 months.

Materials and Methods:

MRIs were performed on 32 patients who underwent ACL reconstruction at 6 and 12 months following surgery. The measurements were made of the background, posterior cruciate ligament, and signal intensity of the graft. The calculation of the signal noise quotient (SNQ) was done. The correlations between the international knee documentation committee (IKDC) at 6 and 12 months and the SNQ values at 6 and 12 months were assessed.

Results:

After 6 months, the mean SNQ value was 3.8953 ± 2.6561, and after 12 months, it was 2.6013 ± 1.7337. In addition, the mean IKDC was 43.3 preoperatively, 52.8125 ± 9.24728 at 6 months’ follow-up and 70.6875 ± 8.32578 at 12 months’ follow-up. The 12-month SNQ values showed a significant decrease, according to RMANOVA (F[1,62] = 6.50871, P = 0.01316). Conversely, the IKDC scores at 12 months demonstrated a statistically significant rise (F[1,62] = 66.03667, P < 0.001).

Conclusion:

MRI is a reliable investigation to assess the graft maturity. In our study, hamstring graft demonstrated superior maturity at 12 months as compared to 6 months’ postsurgery. There was a noteworthy inverse relationship between graft SNQ and IKDC scoring. MRI assessment at 6 months and 12 months is desirable to know graft’s maturity and helps to modify the rehabilitation protocol.
Evaluation of Return to Military Activities after Combining Anterior Cruciate Ligament Reconstruction with Modified Lateral Extra-articular Tenodesis Versus Anterior Cruciate Ligament Reconstruction Alone in Primary Anterior Cruciate Ligament Tear in Soldiers. A Randomized Comparative Study
Authors: Gupta T. P. , Rai S. K. , Sirohi Bhavya , Kale Amit , Kashid Manoj , Negi R. S.
Published: October 2024

Background:

This study aimed to assess the clinical result, complications, failure rate, and return to resuming military duty of a single-stage anterior cruciate ligament reconstruction (ACLR) procedure utilizing quadrupled semitendinosus tendon graft joint with modified lateral extra-articular tenodesis (LET). This study evaluates the potential impact of combined modified LET with ACLR versus ACLR alone on the rate of return to high-impact military activities, which we call return to sports (RTSs), and the subsequent rate of the anterior cruciate ligament (ACL) graft failure.

Materials and Methods:

A total of 198 soldiers with primary ACL tears with a high-grade pivot test (grade 3) were included and randomized using the simple randomized method and divided into two groups. A consecutive cohort of military personnel with an isolated ACL tear undergoing ACLR with modified LET (group A, n = 116) and ACLR alone (group B, n = 82) were analyzed between 2016 and 2021. Both groups were followed up for a minimum of 2 years. Soldiers underwent a survey evaluating knee function (knee injury and osteoarthritis outcome score [KOOS]), RTS criteria (RTS type), symptoms (International Knee Documentation Committee [IKDC] subjective), activity level (Tegner score), and fear of movement (Tampa Scale of Kinesiophobia-11) to assess psychological readiness for sport participation.

Results:

Among these, a mean age of 32 ± 2.93 years underwent primary ACLR with modified LET (n = 116) or without LET (n = 82) procedure. A total of 31 soldiers (15.6%) experienced ACL graft failure, including 26 (31.7%) reconstructions without LET and 5 (4.3%) with LET. Combined with LET during primary ACLR, it lowered the risk of graft failure by 2.8 times. Multivariable analysis revealed a significant reduction in graft rupture risk (relative risk = 0.325, P = 0.029) associated with LET compared to ACLR alone after adjusting for age, anthropometric factors, and tibial slopes. 105 out of 113 (90.5%) soldiers were able to return to military duty in group A (combined ACLR with modified LET), whereas 51 of 81 (62.9%) of the soldiers who underwent ACLR alone (group B) returned to military duty (P = 0.05).

Conclusion:

At 24 months postoperatively, combined ACLR plus LET showed a significantly higher RTS rate than ACLR alone. The combined ACLR with the modified LET group also showed a lower failure rate than the ACLR alone group. No marked differences were observed in KOOS sub-scores, IKDCsubjective, and Tegner activity scores.
Lethal Complication of Postairway Stenting to Trachea and Left Main Bronchus: A Case Series with Discussion of the Diagnosis and Management
Authors: Lin Cheng-Jung , Huang Tsai-Wang , Pu Ta-Wei , Lin Kuan-Hsun
Published: October 2024

The insertion of a metallic airway stent is a valuable method for the treatment of benign and malignant airway stenosis and tracheoesophageal fistula. Although stenting for airway stenosis has become widely popular with favorable outcomes, several complications can arise after stenting, such as migration, tendency for stent fracture, and ingrowth of tumor or granulation tissue into the stent. Very few of these reports have described the complications of poststenting pneumothorax. We report the cases of three patients diagnosed with squamous cell carcinoma of the esophagus, complicated by tracheoesophageal fistula, and treated with a tracheal stent or bronchial stent, who developed poststenting pneumothorax.
Relationship of Serum Vitamin D Levels to the Severity of Migraine
Authors: Ozomma Simon Izuchukwu , Oparah Sidney Kelechi , Danesi Mustapha Abudu , Ojini Francis Ibe , Anyanwu Roosevelt Amaobichukwu
Published: October 2024

Background:

Most studies done on Vitamin D deficiency in migraine focused more on headache frequency than intensity and severity of the condition. This study is aimed at determining the relationship between serum Vitamin D levels and severity of migraine in a Nigerian setting.

Materials and Methods:

Using a cross-sectional analytical study design, adult patients with migraine consecutively attending the neurology clinic at the Lagos University Teaching Hospital, were recruited on fulfilling the study criteria. Their age- and sex-matched healthy headache-free controls were also recruited. Demographic information and clinical parameters were obtained with an interviewer-administered questionnaire. Headache severity and pain intensity were documented using incorporated headache disability index (HDI) and numerical rating scale (NRS) tools, respectively. Serum levels of Vitamin D, calcium and albumin were assayed for all study participants.

Results:

The participants comprised 35 migraine and 50 control subjects. The migraine subjects comprised 10 males and 25 females, with mean ages of 29.4 ± 9.3 and 40.0 ± 11.1 years respectively (P = 0.01). The mean serum Vitamin D levels among migraine and control participants were 43.45 ng/ml ± 16.84 and 48.78 ng/ml ± 23.33, respectively (P = 0.31). The mean NRS was 7.3 ± 1.2 while the mean HDI was 44.7 ± 19.1 among migraine patients. There was no significant correlation between serum Vitamin D levels and pain intensity (r = 0.29, P = 0.9), and no correlation with HDI (r = 0.004, P = 0.96).

Conclusion:

The serum Vitamin D levels among migraine and control participants were not significantly different. No significant relationship was found between serum Vitamin D level and headache severity index or pain intensity in migraine patients.
Health-care Utilisation among Elderly People with Chronic Medical Conditions in a Secondary Health-care Center, Southwestern Nigeria
Authors: Akingunola Olumuyiwa , Sogunle Taiwo , Kareem Yessir , Egua Lydia
Published: October 2024

Background:

The elderly population of the world is projected to continue to increase. There is an anticipated increase in the utilisation of health-care services due to chronic diseases and other impairments with resulting pressure on health systems.

Aims:

This study aimed to determine the health-care utilisation of elderly patients with chronic medical diseases attending a secondary health facility in southwestern Nigeria.

Materials and Methods

A structured questionnaire was administered to gather the data from 300 older people by random sampling during follow-up care for those receiving care for more than 6 months following a diagnosis of a chronic disease. SPSS software version 26 was used for the data analysis, and the results are presented in the tables. The Chi-square test was applied to test for associations between the categorical variables, and a logistic regression model was used to rule out confounders, while P < 0.05 was considered to indicate statistical significance.

Results:

The mean age (standard deviation) in the study was 68.26 (7.01) years and 58.3% were females. The average number of routine clinic visits was 4.12, whereas 20.7% had emergency room visits, 6.6% were referred to specialists, and 33.3% had laboratory investigations. After logistic regression was applied, living conditions, average monthly income, and treatment for diabetes were found to be significant factors for the utilisation of care.

Conclusion:

The provision of rich social support, improving economic empowerment, and performing screening and timely management for diabetes will improve preventive care while reducing the use of expensive and specialised care for older people.
Advances in therapies using mesenchymal stem cells and their exosomes for treatment of peripheral nerve injury: state of the art and future perspectives
Authors: Aldali Fatima , Deng Chunchu , Nie Mingbo , Chen Hong
Published: October 2024

“Peripheral nerve injury” refers to damage or trauma affecting nerves outside the brain and spinal cord. Peripheral nerve injury results in movements or sensation impairments, and represents a serious public health problem. Although severed peripheral nerves have been effectively joined and various therapies have been offered, recovery of sensory or motor functions remains limited, and efficacious therapies for complete repair of a nerve injury remain elusive. The emerging field of mesenchymal stem cells and their exosome-based therapies hold promise for enhancing nerve regeneration and function. Mesenchymal stem cells, as large living cells responsive to the environment, secrete various factors and exosomes. The latter are nano-sized extracellular vesicles containing bioactive molecules such as proteins, microRNA, and messenger RNA derived from parent mesenchymal stem cells. Exosomes have pivotal roles in cell-to-cell communication and nervous tissue function, offering solutions to changes associated with cell-based therapies. Despite ongoing investigations, mesenchymal stem cells and mesenchymal stem cell–derived exosome-based therapies are in the exploratory stage. A comprehensive review of the latest preclinical experiments and clinical trials is essential for deep understanding of therapeutic strategies and for facilitating clinical translation. This review initially explores current investigations of mesenchymal stem cells and mesenchymal stem cell–derived exosomes in peripheral nerve injury, exploring the underlying mechanisms. Subsequently, it provides an overview of the current status of mesenchymal stem cell and exosome-based therapies in clinical trials, followed by a comparative analysis of therapies utilizing mesenchymal stem cells and exosomes. Finally, the review addresses the limitations and challenges associated with use of mesenchymal stem cell–derived exosomes, offering potential solutions and guiding future directions.
Microglia overexpressing brain-derived neurotrophic factor promote vascular repair and functional recovery in mice after spinal cord injury
Authors: Zeng Fanzhuo , Li Yuxin , Li Xiaoyu , Gu Xinyang , Cao Yue , Cheng Shuai , Tian He , Mei Rongcheng , Mei Xifan
Published: October 2024

Spinal cord injury represents a severe form of central nervous system trauma for which effective treatments remain limited. Microglia is the resident immune cells of the central nervous system, play a critical role in spinal cord injury. Previous studies have shown that microglia can promote neuronal survival by phagocytosing dead cells and debris and by releasing neuroprotective and anti-inflammatory factors. However, excessive activation of microglia can lead to persistent inflammation and contribute to the formation of glial scars, which hinder axonal regeneration. Despite this, the precise role and mechanisms of microglia during the acute phase of spinal cord injury remain controversial and poorly understood. To elucidate the role of microglia in spinal cord injury, we employed the colony-stimulating factor 1 receptor inhibitor PLX5622 to deplete microglia. We observed that sustained depletion of microglia resulted in an expansion of the lesion area, downregulation of brain-derived neurotrophic factor, and impaired functional recovery after spinal cord injury. Next, we generated a transgenic mouse line with conditional overexpression of brain-derived neurotrophic factor specifically in microglia. We found that brain-derived neurotrophic factor overexpression in microglia increased angiogenesis and blood flow following spinal cord injury and facilitated the recovery of hindlimb motor function. Additionally, brain-derived neurotrophic factor overexpression in microglia reduced inflammation and neuronal apoptosis during the acute phase of spinal cord injury. Furthermore, through using specific transgenic mouse lines, TMEM119, and the colony-stimulating factor 1 receptor inhibitor PLX73086, we demonstrated that the neuroprotective effects were predominantly due to brain-derived neurotrophic factor overexpression in microglia rather than macrophages. In conclusion, our findings suggest the critical role of microglia in the formation of protective glial scars. Depleting microglia is detrimental to recovery of spinal cord injury, whereas targeting brain-derived neurotrophic factor overexpression in microglia represents a promising and novel therapeutic strategy to enhance motor function recovery in patients with spinal cord injury.
Magnetic resonance imaging tracing of superparamagnetic iron oxide nanoparticle–labeled mesenchymal stromal cells for repairing spinal cord injury
Authors: Mai Xiaoli , Xie Yuanyuan , Wu Zhichong , Zou Junting , Du Jiacheng , Shen Yunpeng , Liu Hao , Chen Bo , Zhu Mengxia , Shi Jiong , Chen Yang , Zhang Bing , Zhu Zezhang , Wang Bin , Gu Ning
Published: October 2024

Mesenchymal stromal cell transplantation Is an effective and promising approach for treating various systemic and diffuse diseases. However, the biological characteristics of transplanted mesenchymal stromal cells in humans remain unclear, including cell viability, distribution, migration, and fate. Conventional cell tracing methods cannot be used in the clinic. The use of superparamagnetic iron oxide nanoparticles as contrast agents allows for the observation of transplanted cells using magnetic resonance imaging. In 2016, the National Medical Products Administration of China approved a new superparamagnetic iron oxide nanoparticle, Ruicun, for use as a contrast agent in clinical trials.

In the present study, an acute hemi-transection spinal cord injury model was established in beagle dogs. The injury was then treated by transplantation of Ruicun-labeled mesenchymal stromal cells. The results indicated that Ruicun-labeled mesenchymal stromal cells repaired damaged spinal cord fibers and partially restored neurological function in animals with acute spinal cord injury. T2*-weighted imaging revealed low signal areas on both sides of the injured spinal cord. The results of quantitative susceptibility mapping with ultrashort echo time sequences indicated that Ruicun-labeled mesenchymal stromal cells persisted stably within the injured spinal cord for over 4 weeks. These findings suggest that magnetic resonance imaging has the potential to effectively track the migration of Ruicun-labeled mesenchymal stromal cells and assess their ability to repair spinal cord injury.
SIRT1/NOX1 pathway mediated ameliorative effects of rosmarinic acid in folic acid-induced renal injury
Authors: Mottaghi Maryam , Eidi Akram , Heidari Fatemeh , Movahhed Tahereh Komeili , Moslehi Azam
Published: October 2024

Background and purpose:

Renal injury is a serious disorder that can be caused by some diseases or agents. Rosmarinic acid (RA) is a natural and safe compound with powerful antioxidant and anti-inflammatory properties. In this study, the ameliorative effects of RA were assayed in folic acid (FA)-induced renal injury by involving the SIRT1/NOX1 pathway.

Experimental approach:

Thirty-six male C57/BL6 mice were divided into 6 groups (n = 6) including control, vehicle, FA, RA, FA + RA 50, and FA + RA 100. After 10 days, blood urea nitrogen (BUN), creatinine, and oxidative stress were measured. The expression of SIRT1 and NOX1 proteins was evaluated by western blot. Also, histopathological alterations were assayed by H&E and PAS staining methods.

Findings/Results:

BUN and creatinine were significantly higher in the FA group compared to the control group; however, their levels decreased after RA treatment in both doses. A significant decrease was observed in swelling, necrosis, and desquamation of tubular epithelial cells in the FA + RA 50 and FA + RA 100 groups compared to the FA group. RA in the animals receiving FA increased SIRT1 expression and the levels of GSH and SOD compared to the FA group. RA in the animals receiving FA showed a significant decrease in NOX1 expression and MDA level compared to the FA group.

Conclusion and implications:

The findings declared that the administration of RA has positive effects against renal damage induced by FA. The effect might result from involvement in the SIRT1/NOX1 pathway and thereby attenuation of oxidative stress.
A multi-epitope self-amplifying mRNA SARS-CoV-2 vaccine design using a reverse vaccinology approach
Authors: Claudia Brigitta , Nugrahapraja Husna , Giri-Rachman Ernawati Arifin
Published: October 2024

Background and purpose:

Massive vaccine distribution is a crucial step to prevent the spread of SARS-CoV2 as the causative agent of COVID-19. This research aimed to design the multi-epitope self-amplifying mRNA (saRNA) vaccine from the spike and nucleocapsid proteins of SARS-CoV2.

Experimental approach:

Commonly distributed constructions class I and II alleles of the Indonesian population were used to determine peptide sequences that trigger this population’s high specificity T-cell response. The best vaccine candidate was selected through the analysis of tertiary structure validation and molecular docking of each candidate with TLR-4, TLR-8, HLA-A*24:02, and HLA-DRB1*04:05. The selected multi-epitope vaccine combined with the gene encoding the replication machinery that allows the RNA amplification in the host cell.

Findings/Results:

Seven B-cell and four T-cell epitopes from the protein target were highly antigenic and conserved, non-allergen, non-toxic, and hydrophilic. Tertiary structure validation then determined the best multi-epitope construction with 269 AA in length containing hBD-2 adjuvant and PADRE. Most residues are predicted to be accessible by solvent and show high population coverage (99,26%). Molecular docking analysis demonstrated a stable and strong binding affinity with immune receptors. A recombinant plasmid as the template for mRNA production was constructed by inserting the multi-epitope DNA and non-structural polyprotein 1-4 gene of VEEV, which encodes the RNA replication complex to the cloning site of pcDNA3.1(+).

Conclusion and implication:

In silico, design of self-amplifying mRNA could be a potential COVID-19 vaccine candidate since its ability to be amplified in the host cell can efficiently reduce the intake doses.
The protective effect of hydroalcoholic Citrus aurantifolia peel extract against doxorubicin-induced nephrotoxicity
Authors: Sandhiutami Ni Made Dwi , Desmiaty Yesi , Pitaloka Putu Diah Utari , Salsabila Salsabila
Published: October 2024

Background and purpose:

Doxorubicin chemotherapy is a widely used treatment for various cancers, including breast, ovarian, and uterine cancers, among others. However, long-term use can cause nephrotoxicity side effects. Some citrus flavonoids have demonstrated nephroprotective activity; therefore, this study aimed to test the nephroprotective effectiveness of Citrus aurantifolia peel extract in protecting and reducing kidney damage caused by doxorubicin.

Experimental approach:

Citrus aurantifolia peel was dried, ground, and extracted by ultrasonication (70% ethanol), then the extract was dried. Twenty-five female Sprague-Dawley rats were divided into 5 groups including the normal group (control), positive control (doxorubicin) group receiving doxorubicin at the repeated intraperitoneal (i.p.) dose of 4 mg/kg/day on days 2, 6, 10, and 14, and treatment groups receiving Citrus aurantifolia peel extract (CPE) with the doses of 100, 200, and 400 mg/kg/day orally for 14 days, and doxorubicin (4 mg/kg/day, i.p.) on days 2, 6, 10 and 14. On day 15, the rats were euthanized for the measurements of MDA, superoxide dismutase (SOD), catalase, kidney function (measuring blood urea nitrogen (BUN), creatinine, albumin serum levels), and renal histopathology.

Findings/Results:

The CPE yield was 16.13%. CPE could significantly reduce the levels of MDA, and increase SOD and catalase activities compared with the doxorubicin-induced nephrotoxic model. CPE could increase renal function by reducing BUN and creatinine levels, increasing albumin, and improving the histopathology of the kidney.

Conclusion and implications:

CPE has a potential effect as nephroprotective against doxorubicin-induced toxicity in renal through antioxidant capacities and increased renal function.
On the dualizability of fusion 2-categories
Authors: Décoppet Thibault D.
Published: October 2024

Over an arbitrary field, we prove that the relative 2-Deligne tensor product of two separable module 2-categories over a compact semisimple tensor 2-category exists. This allows us to consider the Morita 4-category of compact semisimple tensor 2-categories, separable bimodule 2-categories, and their morphisms. Categorifying a result of Douglas, Schommer-Pries, Snyder [Mem. Amer. Math. Soc. 268 (2021)], we prove that separable compact semisimple tensor 2-categories are fully dualizable objects therein. In particular, it then follows from the main theorem of Décoppet [Comp. Math.] that, over an algebraically closed field of characteristic zero, every fusion 2-category is a fully dualizable object of the above Morita 4-category. We explain how this can be extended to any field of characteristic zero. Finally, we discuss the field theoretic interpretation of our results.
Post-COVID-19 Vaccination Meningitis and Meningoencephalitis: A Systematic Review of Case Series and Case Reports
Authors: Taiyeb Khosroshahi Mahdieh , Hamidi Sana , Kangari Parisa , Gharakhanlou Sohrab , Hamidi Zahra , Jafari-Sales Abolfazl , Shamekh Ali , Bannazadeh Baghi Hossein , Morsali Soroush
Published: October 2024

Meningitis and meningoencephalitis, as inflammatory diseases of the brain parenchyma, are serious events reported sporadically after coronavirus disease 2019 (COVID-19) vaccination. However, there is a lack of systematic reviews consolidating these reported cases. By using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a comprehensive search was conducted across PubMed, Scopus, Embase, and Web of Science databases. All case reports and series discussing the emergence of meningitis and meningoencephalitis after COVID-19 vaccination were included and evaluated using the Joanna Briggs Institute critical appraisal tool. Out of 967 records, 27 studies with 31 patients were eventually included. The most commonly reported symptoms were headaches and fever. About one-third of the patients exhibited positive meningeal signs. Most of the findings in the computed tomography scans and magnetic resonance images revealed no significant changes or enhancement in the leptomeninges. Cerebrospinal fluid analysis dominantly suggested aseptic meningitis, and about 80.6% of the patients experienced a full recovery. After a detailed review of the reported cases, further research is needed to establish a definitive correlation between meningitis and COVID-19 vaccination on a larger scale.
Product Governance and Management for Software-defined Battery Electric Vehicles
Authors: Abdul Hamid Umar Zakir
Published: October 2024

In recent years, battery electric vehicles (BEVs) have experienced significant
sales growth, marked by advancements in features and market delivery. This
evolution intersects with innovative software-defined vehicles, which have
transformed automotive supply chains, introducing new BEV brands from both
emerging and mature markets. The critical role of software in software-defined
battery electric vehicles (SD-BEVs) is pivotal for enhancing user experience and
ensuring adherence to rigorous safety, performance, and quality standards.
Effective governance and management are crucial, as failures can mar corporate
reputations and jeopardize safety-critical systems like advanced driver
assistance systems.

Product Governance and Management for Software-defined Battery Electric
Vehicles addresses the complexities of SD-BEV product governance and
management to facilitate safer vehicle deployments. By exploring these
challenges, it aims to enhance internal processes and foster cross-geographical
collaborations, assisting automotive product managers in integrating
comprehensive considerations into product strategies and requirements.

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Implementacja do polskiego porządku prawnego dyrektywy platformowej – problem domniemania stosunku pracy (wprowadzenie do dyskusji)
Authors: Duraj Tomasz
Published: October 2024

The aim of this study is to present the key challenge faced by the Polish legislator, which is the implementation of the construction of the presumption of employment relationship as regulated in Art. 5 of the Directive in relation to platform employment. In my opinion, the correct implementation of this construction into the Polish legal system will require extending this mechanism to all employment relationships, including those operating outside the online platform sector. In this sense, the implementation of this mechanism will constitute a revolution for the entire Polish employment law. The implementation of the presumption of an employment relationship into our legal order is of fundamental importance for all employment relations in Poland. It will affect not only the online platform market, but also all individuals engaged in gainful employment. The author critically addresses the proposed solutions, pointing out the flaws and risks associated with introducing this legal construction into Polish labour law.
Ochrona sygnalistów w miejscu pracy – portugalski model implementacji dyrektywy (UE) 2019/1937
Authors: Grześków Małgorzata
Published: October 2024

This article addresses the protection of whistleblowers in employment relationships. The European Union has created a framework (minimum standards) for the protection of whistleblowers in Directive 2019/1937. As an act of EU law, the Directive 2019/1937 is binding on each Member State to which it is addressed with regard to the result to be achieved, but leaves national authorities freedom to choose the form and means. This article presents the model of implementation of the Directive 2019/1937 used in Portugal (the country that was one of the first to implement the Directive).
Obowiązek „dalszego zatrudnienia” regulowany art. 7555 Kodeksu postępowania cywilnego jako forma zabezpieczenia powództwa (byłego) pracownika
Authors: Wujczyk Marcin
Published: October 2024

In his work, the author describes and evaluates the institution of securing labour claims by imposing an obligation on the employer to continue employing the employee until the proceedings have become final, introduced in Art. 7555 of the Civil Procedure Code. First, a description of the legal nature of the new type of security is made. In the next part, the author defines the catalogue of entities entitled to benefit from the security of Art. 7555 of the Civil Procedure Code, analysing the concept of an employee subject to special protection against termination of the employment relationship with or without notice. In addition, the study fleshes out the formal issues related to the application for security under Art. 7555 of the Civil Procedure Code and the issuance of an order granting such security. This is followed by a consideration of the permissibility of amending a security order that has been issued, and an analysis of the concept of “continued employment,” particularly in terms of what the obligation to continue employment means for the employer and what is the legal status of the entitled person during the period of security. The author also presents the issue of the compulsory execution of the issued security order and indicated when the security ceases. The work also considers the issue of the permissibility of the termination of the employment relationship established in the execution of the freezing order under Art. 7555 of the Civil Procedure Code. In addition, the author discusses in his considerations the rules of settlement between the parties when the action of the employee-author is dismissed. Also included are comments on the applicability of the provisions of Art. 7555 of the Civil Procedure Code to a change notice. Finally, the author evaluates the institution of security under Art. 7555 of the Civil Procedure Code, in which, while referring positively to the very concept of introducing a means of protecting employee claims, he points out the critically assessed aspects of the new regulation.
Identificação e Valorização de Conhecimentos Tradicionais por meio do Mapeamento Participativo da Pesca Artesanal no Município de Baía Formosa (RN)
Authors: Soares Larícia Gomes , Farias Juliana Felipe
Published: October 2024

O estudo apresenta um processo de mapeamento participativo aplicado à comunidade pesqueira de Baía Formosa (RN), destacando a importância da participação ativa dos membros locais na coleta de dados e na construção de mapas. O objetivo é valorizar os conhecimentos tradicionais dos pescadores, espacializando-os de maneira coletiva. O processo foi dividido em fases, que incluíram o levantamento de informações junto à comunidade, a transposição dos dados analógicos para o formato digital, utilizando Sistemas de Informação Geográfica (SIG), e a validação dos resultados pelos próprios pescadores. O mapa resultante detalha aspectos da atividade pesqueira local, como espécies capturadas, técnicas de pesca, zonas de profundidade e territórios diversos. Além disso, foi criado um calendário de pesca participativo, que sintetiza as principais informações sobre espécies, períodos de pesca, técnicas utilizadas e localizações das atividades. A colaboração entre pesquisadores e a comunidade foi essencial para garantir a precisão dos dados representados. O estudo reforça a cartografia social como uma prática importante para o desenvolvimento comunitário e a conservação ambiental, destacando a promoção da inclusão e o respeito aos saberes locais na gestão do território, afirmando o modo de vida tradicional pesqueiro.
Physical Exercise and Mental Health in Adolescents: Scoping Review
Authors: Carvajal Tello Nathali , Segura-Ordoñez Alejandro , Banguero Oñate Hilary Andrea , Hurtado Mosquera Juan David
Published: October 2024

Objective. To identify the most implemented exercises and their prescription, in addition to the effects of exercise on mental health in adolescents.
Methods. A scoping review was performed from search of electronic databases: PubMed, Science Direct, Scopus, Springer, Google Scholar, from 23/08/2023 to 01/01/2024 in English, Spanish, and Portuguese language, including randomized clinical trial and cohort type studies.
Results. A total of 7 articles were included: 57.14% controlled clinical trials, 100% in English. The number of participants was 85,637 aged 12 to 16 years. Intervention time ranged from 8 to 43 weeks, 2 to 5 times per week, 1 session per day, duration per session 10 to 120 minutes. The most used type of training was Programmed Physical Education followed by High Intensity Interval Training.
Conclusions. Exercises such as Programmed Physical Education, High Intensity Interval Training, Moderate to Vigorous Physical Activity are included, which show positive effects on the increase in psychological well-being, quality of life and a significant decrease in anxiety and stress symptoms.
Strategi Pemasaran Produk Kecantikan: Peran Celebrity Endorser dan Viral Marketing dalam Meningkatkan Minat Beli Scarlett Whitening
Authors: Anatasia Tessa , Sutiono Lucia , Sin Bong Kim , Khumaira Shahnaz , Yustin Syarifah
Published: October 2024

This study aims to examine the impact of celebrity endorsers and viral marketing on purchase interest in Scarlett Whitening beauty products, focusing on the beauty community in Singkawang City. Using a quantitative approach, data was collected through questionnaires distributed to a purposive sample of 100 customers and consumers. The independent variables are celebrity endorsers and viral marketing, while the dependent variable is purchase interest. T-test results reveal that both celebrity endorsers and viral marketing significantly influence purchase interest individually. Additionally, F-test results confirm that these factors collectively have a significant simultaneous effect on purchase interest in Scarlett Whitening beauty products in Singkawang City.
Analisis Pengaruh Electronic Word of Mouth, Brand Image, Brand Trust terhadap Keputusan Pembelian pada Marketplace Shopee
Authors: Herniati Herniati , Sudarso Erik , Warsiningsih Tina , Hartono Sigit Tri , Darmasari Elita
Published: October 2024

This study aims to analyse the effect of Electronic Word of Mouth (e-WOM), brand image, and brand trust on purchasing decisions at the Shopee marketplace. The research method used is quantitative. Data was collected through questionnaires distributed to 100 Shopee users in Indonesia. The results of the analysis show that e-WOM, brand image, and brand trust have a positive and significant influence on purchasing decisions. Of the three variables, brand trust has the most dominant influence in shaping consumer decisions to make purchases. This research provides implications that Shopee needs to increase consumer trust and strengthen brand image to drive purchasing decisions through effective digital marketing strategies.
Memahami Tujuan Pendidikan Islam, Multi, Inter dan Transdisipliner
Authors: Mushofa Mushofa , Sabda Syaifuddin , Fidzi Ridhahani , Yaqin Husnul
Published: October 2024

This paper discusses understanding the purpose of Islamic education in a multi, inter and transdisciplinary approach. This issue is very urgent, given the importance of understanding the teachings of Islam in a comprehensive manner. Islam as a religion does not only teach the realm of ubudiyah, but also mu'amalah. It is in the realm of mu'amalah that humanity is faced with the complexity of life problems that must be resolved. Especially in modern times like today, an approach from various scientific angles is needed. This research is in the form of library research with a qualitative descriptive approach. After the study, it is concluded that Islamic education is not just a transfer of knowledge, but also a holistic process that forms individuals with noble character. In the context of an increasingly advanced life, Islamic education as a scientific discipline cannot stand alone in solving problems in society. There is a need for multi, inter and transdisciplinary science, so scientific integration here is very necessary.
Enhancing Conceptual Understanding of Electricity and Magnetism through VR Simulations
Authors:   Senior High School - Science Department Department of Education, Aloran Trade High School Aloran, Philippines 7206, Cabural Adones B.
Published: October 2024

The study explores the efficacy of Virtual Reality (VR) simulations in enhancing students’ conceptual understanding of electricity and magnetism, using the Labster platform. Traditional teaching methods often need to adequately convey the complexities of these topics, leading to limited student engagement and poor comprehension. The research compares two groups: one receiving traditional instruction and another using VR-based simulations. The study found that students in the experimental group, who used VR simulations, showed a 35% improvement in post-test scores, compared to a 15% improvement in the control group. The VR group also reported higher levels of engagement and found abstract concepts such as electric fields and circuits easier to understand through interactive, immersive learning environments. Teachers noted that VR aided in visualizing difficult concepts, although challenges included a learning curve in technology usage and the need for proper integration into curriculum. The findings suggest that VR, when used as a supplemental tool, has the potential to significantly improve learning outcomes in physics education. However, the study highlights the need for further research into long-term impacts and accessibility issues and strategies to better integrate VR into traditional teaching methods.
Análise das propriedades físico-químicas de adjuvantes e sua influência no espectro de gotas e na deriva em túnel de vento
Authors:   , Basílio Sérgio
Published: October 2024

A necessidade de melhorar cada vez mais a eficiência de aplicação de pesticidas e o controle fitossanitário, levou ao desenvolvimento de adjuvantes. No entanto, apesar da evolução dos adjuvantes, percebe-se que o controle de pragas, doenças e ervas daninhas continua sendo um gargalo na atividade Agrícola, assim são feitas aplicações de pesticidas em intervalos menores de modo a reduzir o nível de dano. A redução dos intervalos de aplicação pode aumentar a resistência das enfermidades, e contribuir no desequilíbrio ecossistémico e até em última instância aumentar os custos financeiros. Assim, é fundamental compreender a dinâmica dos adjuvantes melhorar a sua aplicação e garantir a sustentabilidade da Agricultura. Neste sentido, realizaram-se experimentos objetivando-se avaliar as características físico-químicas, o espectro de gotas e o potencial de redução de deriva de 8 adjuvantes comerciais. Para o efeito, nas propriedades físico-químicas avaliaram-se tensão superficial, condutividade elétrica, densidade, pH, ângulo de contato, e no espectro de gotas os diâmetros volumétricos e o percentual de volume de gotas com diâmetro menor que 100 μm e maior que 500 μm, por fim foi avaliada a deriva em túnel de vento. Os resultados indicaram que pode não existir uma relação direta entre as propriedades físico-químicas avaliadas com o espectro de gotas e deriva. Porém, alguns adjuvantes aumentaram o tamanho de gota. Além disso, a pressão de pulverização afeta de formas distintas o funcionamento dos adjuvantes, mas em geral, quanto maior for a pressão maior pode ser a redução do diâmetro mediano volumétrico e o aumento da porcentagem de gotas menor que 100 μm. No entanto os adjuvantes com percentual de volume de gotas menor que 100 μm maior apresentaram-se mais suscetíveis a deriva. Os adjuvantes a base de óleos apresentam melhor performance, porém é fundamental considerar o tipo de óleo a ser utilizado, para melhoria da qualidade de aplicação de pesticidas, isto porque cada óleo pode possuir dinâmicas diferentes. Palavra-chave: Adjuvantes; Propriedades físico-químicas; Espectro de gotas; Potencial de redução de deriva.
DEX Immunotherapy Pharmaco-Biotechnological Advances in Multimodal Therapy for Cancer
Authors:   Department of Oncopathology, OGRD Alliance, USA, Gutiérrez Sandoval Ramón , Rivadeneira Ider ,   Clinical Department, Immunotherapy Support, LatamRecell, Madrid, Spain, Muñoz P Ignacio ,   Clinical Department, LatamRecell, Chile, Iturra F Jordan ,   Clinical Department, LatamRecell, Concepción, Chile, Krakowiak Francisco ,   Department of Morphophysiopathology and Cytodiagnosis, Bioclas Laboratory, Concepción, Chile
Published: October 2024

This article reviews the synergy between pulsed dendritic cell exosome (DEX) immunotherapy and chemotherapy in cancer treatment. DEX exosomes, which act as immune system modulators, enhance chemotherapy efficacy by modifying the tumor microenvironment and activating an immune response targeted against tumor cells. This combination not only amplifies cancer cell destruction but also protects healthy cells, thus reducing systemic adverse effects of chemotherapy. The article highlights preclinical and clinical advances demonstrating the effectiveness of this combined strategy, showing promising results in tumors resistant to conventional treatments. Despite the benefits, challenges such as the high production cost of exosomes and the need to optimize treatment protocols for different cancer types are identified. Additionally, future research directions are presented, focusing on improving personalized treatments through genetically modified exosomes. In conclusion, the combination of DEX and chemotherapy has the potential to revolutionize cancer treatment, enhancing both treatment tolerance and clinical efficacy.
Medicina de precisão genética em obesidade e diabetes
Authors: Rodrigues Silva Myllene , Dos Santos Teixeira Victor Bruno , Yamada Utagawa Claudia
Published: October 2024

A medicina de precisão promete personalizar tratamentos com base em dados genéticos para obesidade e diabetes, enfrentando desafios como falta de adesão e efeitos colaterais. O objetivo desse trabalho, foi compreender a aplicabilidade do uso de variantes genéticas na medicina de precisão para o tratamento da obesidade e diabetes. Foi realizada uma revisão sistemática baseada nas orientações do modelo PRISMA de 2009, com busca de artigos científicos, publicados no período de 2017 a 2023, nos bancos de dados PubMed, SciELO e Google Acadêmico utilizando os descritores “precision medicine” AND “obesity” e “precision medicine” AND “diabetes”. Foram obtidos 10 estudos sobre obesidade e 20 sobre diabetes. Os estudos apontaram os genes e suas respectivas proteínas: LEP (Leptina), LEPR (Receptor da Leptina), MC4R (receptor da melacortina-4), e POMC (proopiomelanocortina) como possíveis marcadores genéticos para a obesidade e os genes e suas respectivas proteínas: HNF4A (Fator Nuclear Hepatocito 4 Alfa), GCK (glucoquinase), HNF1A (HNF1 Homeobox A) e ABCC8 (Subfamília C da Cassete de Ligação ATP Membro 8) foram identificados como influentes para diabetes. Exemplos promissores incluem a perda de peso em pacientes com obesidade comum e deficiência de POMC, e a estabilização da glicemia nos pacientes com mutação em genes que resultam na Diabetes MODY, responsivos a sulfonilureia. Embora tenham sido encontrados no estudo, genes que possam ter potencial para nortear futuros tratamentos, ainda existe a necessidade de mais pesquisas para o desenvolvimento de intervenções terapêuticas eficazes em medicina de precisão.
Cleaning Method Validation for Determination of Residues in Anti-Cancer Drug product for Injection by Using RP-HPLC Technique
Authors: Gorre Vijaya Chandra  , Lakshmi bavisetti
Published: October 2024

Cleaning method validation is a part of good practices in pharmaceutical sector and need to seek the contamination present in production area. OBJECTIVE: An RP-HPLC method for the cleaning samples analysis for Anti-Cancer Drug product Melphalan Hydrochloride for Injection was develop and validated. The method was developed and validated for quantitation of Cleaning of residue left in the vessels of the production equipment’s. The analytical method used to determine the complete cleaning for Melphalan Hydrochloride for Injection by HPLC method. METHOD: The Cleaning validation was performed on Inertsil ODS,C18,(150mm×4.6mm,5μm) chromatographic column temperature at 40°C, and the detection wavelength was set at 260nm. Mobile Phase-A:10mL ammonium acetate, 88mL Purified water, 10mL acetic acid, 2mL Triethylamine, and Mobile Phase-B: 1mL Buffer, 10mL acetonitrile,190mL Purified water, and at a flow rate of 1.5 mL/min, and the injection volume was 10μL. RESULTS: The validation results of Melphalan Hydrochloride were linear over the concentration from 0.10 µg/mL to 0.75µg/mL (r = 1.00) and the recoveries from LOQ to 150% and precision ranged from 50% to 76% (RSD < 30%, n =9). CONCLUSION: This method has been validated successfully and all the results met the acceptance criteria. Hence method of Cleaning Validation is suitable for testing of residue sample of Melphalan Hydrochloride for Injection.
Comparative assessment of the nature of the combined action of insecticides: different methodical approaches
Authors: Veshchemova Tatiana E. , Masaltsev Gleb V. , Rakitskii Valerii N. , Chkhvirkiya Elena G. , Kuzmin Sergey V. , Tsatsakis Aristides M.
Published: October 2024

Introduction. Pesticide mixtures containing insecticide methomyl are commonly used in agriculture. However, the interaction of their active ingredients in a mixture has been insufficiently studied.
The purpose of the study was to evaluate the nature of the combined action of a mixture of insecticides methomyl (carbamate) and bifenthrin (pyrethroid) using various methods: a classical model (orthogonal planning of the experiment using nonlinear variables); a generalized linear regression model for the binomial distribution (probit regression); and an isobologram. The study was conducted at the Federal Scientific Center of Hygiene named after F.F. Erisman of the Federal Service for Supervision in Protection of the Rights of Consumer and Man Wellbeing, according to the protocol approved by the local bioethical commission.
Materials and methods. Ninety male outbred rats were administered 9 combined doses of the insecticides (combinations of LD16, LD33 and LD50 for the individual compounds, as devised from a preliminary study).
Results. Impaired coordination, tremor of the limbs and head, turning into convulsions, rapid (shallow) breathing were observed in all groups. The data on mortality as used to construct 2 mathematical models, as well as to construct an isobologram.
Limitations. The study was limited to studying the indicators of acute oral toxicity, without taking into account the possible repeated exposure.
Conclusion. The models showed that the additive effect for the combination of methomyl and bifenthrin was only observed for combinations when the individual dose of bifenthrin was equal to or greater than 45 mg/kg b.w. (LD33) and the dose of methomyl was less than 30 mg/kg b.w., as all animals receiving a dose
of 30 mg/kg b.w. of methomyl (LD50) in the mixture died. Therefore, the dose of methomyl dictated the toxic effect of the mixture, which should be accounted for in hygienic regulation of methomyl-containing formulations.