bluuebunny/crossref_metadata_2025 huggingface dataset:
Exhalation of different odor indicative of poor prognosis w.s.r. to Arishta in Pushpitakam Indriya Adhyaya of Charaka Samhita
Authors: Devi Pritika , Rana Keshav
Published: May 2021

In medicinal science each disorder is presented with certain signs and symptoms. Many disorders are having certain complications which affect the treatment. Inmodern medicine signs and symptoms of a disease depicting poor prognosis are described. They are very important during the treatment of patient because they have an impact on management of that particular disorder. Similarly in Ayurveda there is Arishta Lakshna i.e. those signs and symptoms when present, they are indicative of imminent death are known as Arishta or Arishta Lakshna. They are always present at the time of terminal illness. As Ayurveda is very patient specific for treatment of ailments therefore every disease the Arishta Lakshna are mentioned in Ayurveda. Knowledge and understanding of these Arishta is important so that physician may know the outcome of the disease and not indulge in the treatment of incurable diseases.
A comprehensive review on registration requirements for Drug Approval in India, South Africa and US
Authors: Patel Veer J. , Patel Dasharath M.
Published: May 2021

The drug approval process is country-specific. The regulatory framework of all the national regulatory agencies differ from one another in terms of administration and product specific guidelines for registration of drug and drug products in a particular country. Every national regulatory authority provides regulatory guidelines for drug or drug product registration and the pharmaceutical industries which rely upon these guidelines prepare drug applications along with all the required administrative, non-clinical and clinical data in the form of a technical dossier which is known as Common Technical Document. This Dossier is prepared either in an electronic format or in the paper submission format. This review focuses on the comparative study of the registration requirements for getting a drug approval in India, South Africa and United States of America. The significant differences between the technical requirements of these three markets have been discussed in detail.
New Era of Formulation as Silver Nanoparticles in Pharma
Authors: Soni Abhishek , Kumar Ajay , Kumar Ashish , Choudhary Amit , Happy ,
Published: May 2021

In various fields of science, nanoparticles of noble metals, particularly silver nanoparticles, have been widely used. Its specific properties, which can be integrated into the materials of biosensors, composite fabrics, cosmetics, antimicrobial applications, conducting materials, and electronic components, make it a very interesting topic to be studied in the fields of chemistry, biology, healthcare, electronics, and other related fields. Such unique features depending on the size, and shape of the silver nanoparticles. Various methods of preparation for the synthesis of silver nanoparticles have been reported, such as electron irradiation, laser ablation, chemical reduction and biological methods.

Keywords: silver nanoparticles (AgNPs), particle size, localized surface plasmonic resonance (LSPR), characterization, application
A review on phytochemical and pharmacological values of Aegle marmelos
Authors: Lomate Krushna A. , Murthy Krishna , Adak Vishal S. , Shete Rajkumar V. V.
Published: May 2021

India is the largest producer of medicinal plants and is rightly referred to as "the World's Botanical Garden." Medicinal plants play a key role in the health and vitality of humans and animals alike. Researchers have been attempting to recognize and validate plant-derived substances for the treatment of various diseases that promote compounds for health and nutrition for the past few years. Bael is a common plant that originated in India (Aegle marmelos). According to a study of the literature, entire parts of the plant, such as roots, barks, leaves, fruits, seeds, and flowers, are used to treat various diseases. Bangladesh, Indonesia, China, and other Asian countries, for example, it is a spiritual, religious, and medicinal plant that can be found all over the world. It has a number of therapeutic applications. Nowadays, various products from various parts of the plant are prepared. The biological profile, botanical description, physicochemical parameters, conventional uses, therapeutic applications and creative aspects are included in this study. The purpose of the present analysis is to compile the general chemical profile, both medicinal and economic value, value-added items such as juice, jam and toffee, and other uses of Aegle marmelos.

Keywords: Aegle marmelos, Rutaceae, Medicinal Values
Preparation, In Vitro characterization and stability studies of ropinirole lipid nanoparticles enriched hydrogel for treatment of neurodegeneration diseases
Authors: Samanthula Kumara Swamy , Alli Ramesh , Gorre Thirupathi
Published: May 2021

Ropinirole (RP), is a selective dopamine agonist that is used alone or with other medications to treat the symptoms of Parkinson’s disease (PD). RP has low bioavailability of only about 50% due to the first-pass metabolism, and it requires frequent dosing during oral administration. The objective of the current research was to develop RP loaded solid lipid nanoparticles (RP-SLNs), nanostructured lipid carriers (RP-NLCs), and their corresponding hydrogels (RP-SLN-C and RP-NLC-C) that might improve efficacy in PD treatment. RP nanoparticles were prepared by homogenization aided probe sonication method and optimized based on particle size, polydispersity index (PDI), zeta potential (ZP), assay, entrapment efficiency, and in vitro release studies. Optimized formulations were converted to hydrogel formulations using Carbopol 934 as a gelling polymer and optimized based on rheological and release characteristics. Optimized formulations were further evaluated using differential scanning calorimetry (DSC), powder X-ray diffractometry (PXRD), scanning electron microscopy (SEM), freeze-drying, and stability study at refrigerated and room temperatures. The optimized RP-SLN formulation showed particle size and entrapment efficiency of 213.5±3.8 nm and 77.9±3.1% compared to 190.6±3.7 nm and 85.7±1.7% for optimized RP-NLC formulation. PXRD supplemented and confirmed DSC results, RP was entrapped in a molecularly dispersed state inside the core of the lipid nanocarrier. Furthermore, RP loaded lipid nanocarriers revealed a spherical shape in SEM images. In vitro release studies demonstrated sustained release profiles for RP from SLNs, NLCs, and their hydrogels over 24 h and were stable over three months at 4ºC and 25ºC storage conditions. Keywords: Parkinson’s disease, Ropinirole, Solid lipid nanoparticles, Nanostructured lipid carriers, Hydrogel.
Synthesis, Characterization and Anti-Microbial Activity of Novel Pyramidine Derivatives
Authors: Ravi Kumar Konda , Sumanjali K.N.S. Sneha , Chandana M. Priya , Srilatha N. , Koteswara Rao P.
Published: May 2021

Pyrimidine is a heterocyclic aromatic organic compound similar to benzene and pyridine, containing two nitrogen atoms at positions 1 and 3 of the six-member ring. Three nucleobases found in nucleic acids, cytosine (C), thymine (T), and uracil (U), are pyrimidine derivatives. A pyrimidine has many properties in common with pyridine, as the number of nitrogen atoms in the ring increases the ring pi electrons become less energetic and electrophilic aromatic substitution gets more difficult while nucleophilic aromatic substitution gets easier. Chalcones react with aminoguanidine to give intermediate compounds which on further reacts with substituted ketones to give Pyramidine derivatives. A total of 6 compounds were synthesized from one scheme and they were recrystallized by appropriate solvents. They were identified and characterized by various spectral methods. In the present study, all synthesized compounds tested for anti bacterial activity and anti-fungal activity. They shown significant activity when compared with standard drug Streptomycin and Miconazole respectively. Keywords: Pyramidines, Characterization, Streptomycin, Miconazole, Anti-microbial activity.
Evaluation of Analgesic Effect of Unani Pharmacopoeial Formulation Habb-E-Suranjan and Raughan-E-Suranjan in Wajaul Mafasil (Joints Pain) Patients: An Open Prospective Clinical Trial
Authors: AHMED NOOR ZAHEER , AHMAD KABIRUDDIN , EZHIL R , ANJUM NIGHAT , KHAN ASIM ALI
Published: May 2021

Wajaul Mafasil (joint pain) is the most prevalent and common cause of morbidity and disability not only in India but also throughout the world. In spite of various scientific developments in conventional medicine, there is no specific therapy or cure available for joints pain particularly when the disease has progressed to chronic stage. Therefore, it is the need of the hour to explore new formulations from herbal sources which are safe and effective. The present trial was undertaken to scientifically validate the Unani pharmacopoeial compound formulations of Habb-e-Suranjan and Raughan-e-Suranjan for its safety and efficacy in patients with joints pain.

Patients with joint pain, who gave written informed consent, were recruited in the study from general OPD of RRIUM, Chennai with the prior approval of the Institutional Ethics Committee. 97 patients completed the study treatment. The treatment protocol was followed for 14 days and the clinical evaluation was done on seventh and fourteenth day of the treatment. At the end of fourteenth day intensity of individual parameters like joints pain, swelling, tenderness and restriction of movement showed statistically significant improvement (p<0.05). Overall therapeutic response of the treatment observed in this study was 100%. It was observed that 47.4% cases were completely relieved; 51.4% cases were relieved while 1.2% cases showed partial relief after the treatment. The laboratory investigations showed that the drugs used in the study were safe as evident by its maintenance. It may be concluded that Habb-e-Suranjan in combination with Raughan-e-Suranjan possesses significant analgesic property and may be a better option for the patients of joint pain.

Keywords: Arthritis, Joints pain, Wajaul Mafasil, Habb-e-Suranjan, Raughan-e-Suranjan
A fisioterapia aquática utilizada no tratamento de pessoas com doença de Parkinson: uma revisão integrativa
Authors: Santos Deividy Tabaczinski dos , Anjos Michele Minozzo dos , Lunelli Lilian Marin , Piccinini Aline Martinelli
Published: May 2021

Introdução: A Doença de Parkinson é degenerativa, progressiva e acomete o sistema nervoso central com diminuição da dopamina, levando a modificações musculoesqueléticas, alterações neurocomportamentais bem como comprometimento cardiorrespiratório. Objetivo: Apresentar uma revisão integrativa da literatura sobre as estratégias aquáticas utilizadas para o tratamento de pessoas com a doença de Parkinson. Metodologia: As buscas foramrealizadas nas bases de dados Pubmed, Lilacs, Scopus, Science Direct e Web of Science no mês de junho de 2020. Os critérios de inclusão foram ensaios clínicos controlados randomizados com abordagem quantitativa de estratégias de terapia aquática para o Parkinson. Foram incluídos para análise artigos publicados de 1950 a junho de 2019. Osdados coletados foram analisados de acordo com o conteúdo, categorizando as informações e  correlacionando com o objetivo da presente revisão integrativa. Resultados: Haviam 3.790 artigos, dos qua is 701 foram excluídos por estarem duplicados e 3079 por não abordarem os objetivos propostos. Ao final, 10 artigos foram selecionados, destes, três utilizaram como método de treinamento o Ai Chi, três os exercícios aeróbicos para melhora das capacidadesfísicas em geral, dois a hidroterapia com exercíc ios de força para melhoria do equilíbrio e marcha, um os exercícios aquáticos de dupla tarefa e por fim, um utilizou a terapia aquática com obstáculos. Considerações finais: Este estudo, ao dissertar sobre as estratégias aquáticas utilizadas para o tratamento da doença de Parkinson, ampliou a compreensão sobre os tratamentos não-medicamentosos para a patologia e dá suporte para a atuação no campo prático para profissionais da saúde.
Evaluation of Serum Potassium Level in Pediatric Gastroenteritis at Children â€“ Welfare Teaching Hospital
Authors: Bakr Mohanad Adnan , Haji Ghazi Farhan , Al-Rubaye Fadil Agla , Abbas Asaad Abullah
Published: May 2021

Objective: To measure the incidence of the hypokalemia in children who are suffered from acute gastroentitis and to estimate their complications.

Method: A prospective  clinical study, is enrolled (153) patients from 1st of January 2017 to  1st of December 2017, at the Children-Welfare Teaching Hospital and it is included the children from ( 1-5 years ) who are firstly admitted to the emergency department and then to the pediatric wards who were  suffered from acute gastroentitis and their serum potassium levels were below (3.5 mmol/l )and is excluded the children with a chronic diarrhea or a bloody diarrhea or with any nutritional diseases, like  marasmus disease, kwashiorkor  or  iron deficiency  anemia disease or parenteral  diarrhea, like ( pneumonia, UTI), or   their ages either below ( 1year )  or more than ( 5 years )  and the study depends on history and physical examination and serial serum potassium levels.

Result: A total of (153) patients with acute gastroenteritis were included in a study, (91) male patients, (62) female patients with male to female ratio (1.4:1), the majority of the patients were from urban areas. In this study, 61(39%) of patients with acute gastroenteritis were complicated by hypokalemia, 92(61%) were not. Of  those with a severe dehydration, 11(23%) had a mild hypokalemia, 17(36%) a moderate, 19(41%) a severe one, patients with a moderate dehydration, 7(50%) had a mild hypokalemia, 5(38%) a moderate, 2(15%) a severe one .Concerning the main complain, 65(44%), had both diarrhea and vomiting, 61(39%), had only diarrhea, 28(17%), had only vomiting.  According to degree of dehydration, there were 72(47%) with moderate dehydration, 81(53%) with a severe dehydration. UOP is poor in (70) with a severe dehydration, and (21) with a moderate dehydration, and is good in (8) with a moderate dehydration, (53) with a severe dehydration. The percentages of the complications were 51(83%), had generalized weakness, 10(17%), and had both generalized weakness and paralytic ileus.

Conclusion: Children with acute gastroenteritis were complicated by a hypokalemia 61(39%) paralytic ileus. Diarrhea and vomiting were the commonest complaint of acute gastroenteritis.
Conceptualizing science communication in flux — a framework for analyzing science communication in a digital media environment
Authors: Faehnrich Birte
Published: May 2021

The pace and scope of digital transformation has brought about fundamental changes to science communication. These changes have so far hardly been reflected in the underlying concepts of science communication as field of research and practice. Against this backdrop, this paper asks how science communication can be conceptualized in response to fundamental societal changes brought about by digital transformation. In response to this question, this paper builds on the results of a Delphi study with 31 outstanding international science communication scholars. It presents a shared approach that conceptualizes online science communication broadly and tackles different points of view by identifying specific characteristics that enable the distinction of different settings of science communication. It is argued that such an approach should be more appropriate for a contemporary analysis of science communication and also helpful for professional communicators and policymakers to understand the interactions of science and society in the context of the digital media landscape.
Transforming housing construction: project cost management challenges
Authors: Vladimirova Irina , Tsygankova Anna , Kosareva Yulia
Published: May 2021

Problems related to the transformation of housing construction based on the transition from shared-equity construction to project financing are being investigated. Along with the socio-economic benefits for consumers and an increase in the stability of the housing market, there are phenomena that negatively affect developers. The changes that affected the legislation governing the relationship between equity holders and developers affected not only the introduction of escrow accounts, but also amended the requirements for the contract of shared-equity construction, the composition of the rights and obligations of the parties to the contract, the methods of securing activities, and increased liability for violation of the terms of the agreement of shared participation. This creates new economic conditions for the activities of developers. The analysis of the changes established by the law by the analysis of differences in legal regulation of activity of builders in two periods became a research objective: when obtaining the construction license before and after the date of introduction of new norm. As a result of the analysis, contradictions are revealed and assessment of their consequences is made for activity of builders. The basic principles for successful transformation are justified: stage, awareness and system, feedback. The conclusions were drawn and concrete proposals were made to amend the legislation, including elimination of contradictions in the dual legal regulation of the activities of developers using various project financing schemes, in agreement with banks for the phased disclosure of escrow accounts, the introduction of costs for transport and engineering infrastructure into the project budget, as well as interest on loans for its creation and others. These measures will preserve the effectiveness of housing construction and the sustainable activities of developers as a result of the transformation of the industry.
Features of determining the market value of retail real estate and individual trade related properties during pre-trial evaluation and forensic examination
Authors: Komar Irina
Published: May 2021

The present article deals with the specifics of valuation of retail property and individual trade related properties on the basis of the international experience and as recommended by International Valuation Standards and RICS (The Royal Institution of Chartered Surveyors (Great Britain)) valuation standards (Red Book). The present article is justified as currently Russia lacks a standard, uniform for the valuers or legal experts, to be used for the purposes of valuation of similar subjects. At the same time, methodical literature is insufficient while there are numerous property disputes that call for pre-court valuations and expert evidence of valuation of such subjects, including numerous litigations arising out of bankruptcy or establishing cadaster value to the amount of market value. The author reviews the existing approaches to valuation of real estate in accordance with both the international and national standards and awards professional recommendations pertaining to the use of the income approach to value retail real properties and individual trade related properties. The definitions and metrics of the above real properties’ groups are described separately. Also, the author provides guidelines for inquiry of the documents and information necessary for the acquisition of the data to be used in the course of valuation and expert evidence. All pricing factors are described in detail in the present article against the examples of retail real properties and individual trade related properties (say, hotel) and explanation of their effect on the market value in case the income approach is applied is provided.
Development stages of ecological architectural and construction design in Russia
Authors: Benuzh Andrey , Sukhinina Elena , Eames Guy Alexander
Published: May 2021

The history of environmental standards, the emergence of environmental architectural and construction design in Russia and the forerunners of environmental certification systems in construction are studied. Historical material is analysed and data is systematised chronologically. Development stages of ecological architectural and construction design in our country are highlighted, their main features are given: Stage 1 (late 17th – mid 20th centuries) — the history of the formation of environmental requirements for the conservation of natural resources and the creation of a comfortable environment for life in urban areas; Stage 2 (mid XXth – early XXIth centuries) — the formation of environmental legislation, the opening of the first Russian Green Building councils, the adaptation of international environmental standards in construction to Russian realities; Stage 3 (the beginning of the XXIth century – the present) — the creation of sustainable requirements in the Russian Federation, increasing the viability of the architectural and construction environment, the introduction of a number of Russian environmental standards in construction, the formation of a national Tech-nical Committee 366 to develop national standards to GOST R series on green construction and promoting green standardization at the national and international levels with the introduction of new green technologies, materials and products for a comfortable living environment.

Today in Russia, a new architectural and construction environment is emerging, aimed at saving resources, preserving health, energy conservation, reducing waste, safety, comfort, preserving biodiversity and creating holistic conditions. To intensify the development of this area, it is necessary to introduce new environmental standards for the design of sustainable space in Russian cities, using best world practice.
Overview of changes in Russian legislation in the field of construction and real estate management in the first half of 2021
Authors: Tkachenko Vladimir
Published: May 2021

The review presents changes in Russian legislation in the field of construction, real estate management, and housing and communal complex management.

The overview reflects the normative legal regulation of public relations in the establishment and legal status of a single customer in the field of construction, the authority of local governments on attracting the management of the organization, creating a universal mechanism for integrated development of territories, the establishment of procedures to ensure housing rights of citizens in the implementation of the integrated development of residential areas, etc.
Crônica de uma resistência anunciada: os traços da distopia crítica em Bacurau, de Kléber Mendonça Filho e Juliano Dornelles
Authors: Torres José Wanderson Lima , Rocha Wagner dos Santos
Published: May 2021

A distopia é um desdobramento da utopia literária que ganhou força especialmente no início do século XX, demonstrando uma habilidade singular em discorrer sobre temáticas sociopolíticas atuais através de um “espelho manchado do porvir”. O texto distópico possui uma predisposição para a narrativa que a aproxima de variados gêneros artísticos e discursivos ao contar a vivência de uma ou mais pessoas num futuro próximo ou não, em que a ordem social proposta é considerada pior do que aquela que existe na realidade. A partir dos anos 1980, críticos e teóricos que estudam o tema sinalizaram uma “guinada distópica”, em que narrativas desse cunho começaram a apresentar vislumbres de esperança em meio ao caos característico da temática com o advento das chamadas distopias críticas. Tomando as considerações acima, o presente trabalho analisa o longa-metragem recente dos diretores brasileiros Kléber Mendonça Filho e Juliano Dornelles, Bacurau (2019), como uma distopia crítica. O filme, que situa sua narrativa no sertão pernambucano “daqui a alguns anos”, apresenta a união de uma comunidade contra a tensão constante de forças externas que trabalharam para sua destruição, restando-lhes apenas o senso de resistência já arraigado em sua história. Procura-se, assim, discorrer sobre esse tipo específico de distopia e como ele está presente dentro da narrativa do filme, transformando-o em um material de aguçada crítica social e política. A presente pesquisa é de cunho bibliográfico e caráter exploratório, apoiando-se teoricamente em nomes como Sargent (1994), Baccolini (2003), Cavalcanti (2011) e Moylan (2016).
“It didn’t Happen that Way”: The Role of Narrative Inconsistencies in Margaret Atwood’s Dystopia the Handmaid’s Tale
Authors: Nunes Menegotto Fernanda , Barros Indrusiak Elaine
Published: May 2021

This article analyzes the role of narrative inconsistencies in Margaret Atwood’s dystopian novel The Handmaid’s Tale (1985) applying the constructivist model proposed by Meir Sternberg and Tamar Yacobi (2015) in their discussion about narrative (un)reliability. The analysis suggests that the inconsistencies which arise when Offred’s narration and the novel’s epilogue—a transcript of an academic symposium taking place in 2195—are juxtaposed have a specific purpose in the novel. This purpose can be identified through the application of two mechanisms of sense-making proposed by Sternberg and Yacobi: the one concerned with the specific perspective adopted in a narrative and the one related to the thematic goals of the text— its function. Thinking of the novel as a communicative act, we explore the ways in which it engages with the notions of both despair and hope which are imbricated in dystopian writing.
Pensando os limites: arte contemporânea e a Mímesis
Authors: De Freitas Eduardo da Silva
Published: May 2021

Resenha de: COSTA LIMA, L. Limite. Rio de Janeiro; Belo Horizonte: Editora da PUC-RIO; Relicário Edições, 2019.
The impact of African Swine Fever Virus on smallholder village pig production: an outbreak investigation in Lao PDR
Authors: Matsumoto Nina , Siengsanan-Lamont J , Halasa Tariq , Young James , Ward Michael , douangngeun Bounlom , theppangna Watthana , Khounsy Syseng , Toribio Jenny-Ann , Bush Russell , Blacksell S.D.
Published: May 2021

African Swine Fever Virus (ASFV) causes a deadly disease of pigs which
spread through southeast Asia in 2019. We investigated one of the first
outbreaks of ASFV in Lao Peoples Democratic Republic amongst smallholder
villages of Thapangtong District, Savannakhet Province. In this study,
two ASFV affected villages were compared to two unaffected villages.
Evidence of ASFV-like clinical signs appeared in pig herds as early as
May 2019, with median epidemic days on 1 and 18 June in the two
villages, respectively. Using participatory epidemiology mapping
techniques, we found statistically significant spatial clustering in
both outbreaks (P < 0.001). Villagers reported known risk
factors for ASFV transmission − such as free-ranging management systems
and wild boar access − in all four villages. The villagers reported
increased pig trader activity from Vietnam before the outbreaks;
however, the survey did not determine a single outbreak source. The
outbreak caused substantial household financial losses with an average
of 9 pigs lost to the disease, and Monte Carlo analysis estimated this
to be USD 215 per household. ASFV poses a significant threat to food and
financial security in smallholder communities such as Thapangtong, where
40.6% of the district’s population are affected by poverty. This study
shows ASFV management in the region will require increased local
government resources, knowledge of informal trader activity and wild
boar monitoring alongside education and support to address intra-village
risk factors such as free-ranging, incorrect waste disposal and swill
feeding.
Manipulating phloem transport affects wood formation but not local nonstructural carbon reserves in an evergreen conifer
Authors: Rademacher Tim , Fonti Patrick , LeMoine James , Fonti Marina , Basler David , Chen Yizhao , Friend Andrew , Seyednasrollah Bijan , Eckes-Shephard Annemarie , Richardson Andrew
Published: May 2021

How variations in carbon supply affect wood formation remains poorly
understood in particular in mature forest trees. To elucidate how carbon
supply affects carbon allocation and wood formation, we attempted to
manipulate carbon supply to the cambial region by phloem girdling and
compression during the mid- and late-growing season and measured effects
on structural development, CO efflux, and nonstructural
carbon reserves in stems of mature white pines. Wood formation and stem
CO efflux varied with location relative to treatment
(i.e., above or below the restriction). We observed up to twice as many
tracheids formed above versus below the treatment after the phloem
transport manipulation, whereas cell-wall area decreased only slightly
below the treatments, and cell size did not change relative to the
control. Nonstructural carbon reserves in the xylem, needles, and roots
were largely unaffected by the treatments. Our results suggest that low
and high carbon supply affects wood formation, primarily through a
strong effect on cell proliferation, and respiration, but local
nonstructural carbon concentrations appear to be maintained
homeostatically. This contrasts with reports of a decoupling of source
activity and wood formation at the whole-tree or ecosystem level,
highlighting the need to better understand organ-specific responses,
within-tree feedbacks, as well as phenological and ontological effects
on sink-source dynamics.
Successful treatment of COVID-19-related acute respiratory distress syndrome with rare blood type: A case report
Authors: Yamada Hiroyuki , Ohtsuru Shigeru , Nagatomo Mika , Korogi Yohei , Shinozuka Ken , Tanabe Naoya , Kai Shinichi , Matsubara Takeshi , Ito Isao , Ihara Masahiro , Tanaka Tomoharu , Kato Genta , Nagao Miki , Date Hiroshi
Published: May 2021

A 62-year-old man with rare blood type exhibited severe respiratory
failure due to novel coronavirus. Extracorporeal membrane oxygenation
was inapplicable, which requires numerous blood products with the same
blood type. We thoroughly restricted fluid volumes by sacrificing renal
function. He was discharged with complete recovery of respiratory and
renal functions.
Clinical features and predictors of multiple bronchoscopy therapy of plastic bronchitis in children
Authors: Zhang Tongqiang , Zhao Lihua , Zheng Jiafeng , Zhao Linsheng , Cui Xiaojian , Xu Yongsheng , Cai Chunquan
Published: May 2021

Background. To analyze the clinical features of children with plastic
bronchitis (PB) and identify the risk factors of multiple flexible
fiberoptic bronchoscopy (FOB) therapy. Methods. Retrospective analysis
was performed on 269 PB children from 2016 to 2019, 144 cases were in
single FOB group, 125 cases were in the multiple FOB group. The clinical
manifestations, laboratory datas, imaging findings and management were
investigated. The different features were compared between the single
FOB group and multiple FOB group. Results. A total of 269 PB children
were collected with a mean age of 6.7 ± 2.8 years. 257 (95.5%) cases
were diagnosed as Mycoplasma pneumonia (MP) infection. The mean duration
of fever was 10.6 ± 3.7 days. All the patients presented with fever, and
62 (23.0%) suffered from hypoxemia, 144 (53.5%) had extrapulmonary
complications. Higher levels of ESR, CRP, PCT, IL-6, LA, LDH, FER and
D-dimer were observed. The proportion of pulmonary consolidation,
segmental or lobar atelectasis, pleural effusion and pleural thickening
were 97.4%, 46.5%, 47.9% and 63.2%, respectively. Furthermore,
multivariate logistic regression analysis showed that N%
>75.5%, LDH >598.5U/L, and
D-dimmer>0.45mg/L were independent isk factors for multiple
FOB therapy. Conclusions. MP is a significant pathogen of PB in
children. Patients with PB are more likely to suffer from persistent
fever, excessive inflammation and severe radiological findings. N%
>75.5%, LDH >598.5U/L and D-dimmer
> 0.45mg/L may be predictors of multiple FOB treatment.
Management of primary acquired melanosis (PAM) of the eye (State of Research Paper)
Authors: Diamandis Dr. Carolina , Davis Alexander , Papadopoulou Sophia
Published: May 2021

With regard to acquired melanosis of the conjunctiva, there is still
neither a worldwide uniform nomenclature nor reliable data on how
frequent this type of pigment disorder is. This is even more true for
the estimation of the risk of progression into cancer as well as the
clinical management of this entity. This short paper presents the
current, partly contradictory scientific knowledge which is available.
Surgical repair of subaortic stenosis resection: 10 years of single-center experience in 65 patients
Authors: Cao Yuefeng , Yang Shuang , Li Wenxiu , Li Lei , Su Junwu , Fan Xiangming
Published: May 2021

Abstract Background Subaortic stenosis (SAS) was a rare congenital heart
disease of left ventricular outflow tract (LVOT), ranging from
“isolated” lesions to “tunnel” or “diffuse” lesions. We conducted
a retrospective study to describe the characteristics of patients with
different lesions and analyze the risk factors for reoperation. Methods
In this study, we examined a single-center retrospective cohort of SAS
patients undergoing resection from 2010 to 2019. Patients were
classified as simple lesion group (n = 37) or complex lesion group (n =
28). Demographics, perioperative findings, and clinical data were
analyzed. Results The surgical effect of the two groups was
significantly lower than that before the operation (p <0.05).
The median age at operation was 6(3-11.8) years. There was no operative
mortality. In complex lesion group, extracorporeal circulation time (CPB
time), aortic cross clamp time (ACC time), mechanical ventilation time
and ICU stay time were longer. The median follow-up period was 2.8 years
(range 1-3.8), with two late death. Six patients (9.2%) required
reoperation due to restenosis or severe aortic insufficiency. The
freedom from reoperation rates at 5 years was 66.7% for simple lesion
but only 52.3% for complex lesion (p = 0.036). Conclusions Although the
lesions include many forms, subaortic stenosis resection was still
satisfactory. However, the reoperation after initial surgical treatment
was not infrequent, especially in patients with complex lesion.
The Invisible Fraud: The Impact of Inattentional Blindness on Auditor Fraud Detection
Authors: Edmonds Mark , Sorensen Kate B. , Stallings Matthew A.
Published: May 2021

Evidence from major fraud investigations has revealed that auditors often fail to attend to visual fraud cues (i.e., red flags) within substantive testing evidence. Research in psychology on inattentional blindness (IB) provides a theoretical framework to explain why this occurs. Although most forensic research has focused on audit planning, we focus on the detection of visual fraud cues embedded in substantive testing evidence. We examine the impact of two interventions, priming and strategic reasoning, on senior audit associates to determine the extent to which these interventions mitigate IB effects. The results indicate that IB effects hinder auditor visual fraud cue detection during the performance of substantive testing procedures and that priming significantly reduced IB effects. The findings provide important implications for practice by drawing the auditor's attention to these effects and by suggesting priming as an efficient and cost-effective intervention to assist in mitigating IB effects in the auditing environment.

Data Availability: Please contact the authors.
Colégio Agrícola de Foz do Iguaçu:
Authors: Cabanha Samuel , Araújo Irani Batista de , Winkert Kelly Gracieli de Oliveira
Published: May 2021

O texto faz uma breve análise e introduz a discussão sobre o papel do Estado no direcionamento e tendências da educação a partir da implantação do Colégio Agrícola na história de Foz do Iguaçu, na década de 50. O objetivo central do texto é explorar duas vertentes, a saber: uma que explora as narrativas e as memórias de alguns “agricolinos”, tendo em vista que, no centro escolar, encontra-se armazenada grande parte da história social e coletiva, e; outra que explora a história desse ambiente educacional, evidenciando a influência do Estado do Paraná na região através da organização do sistema educativo em forma de ensino técnico agrícola que, em parte, reflete a relação entre as demandas econômicas do capital e de como as Instituições Escolares corresponderam frente a esse contexto. A metodologia seguiu os pressupostos teórico-metodológicos da História Oral (HO) tendo como cerne a análise de narrativas. Recorreu-se a discussões que envolvem os conceitos ligados à memória, à identidade e a relação escola-trabalho inerente ao desenvolvimento do modo de produção capitalista, além de valer-se da análise de documentos oficiais e das narrativas. Dessa forma, através de uma particular interpretação este artigo busca contribuir com aqueles que se interessam pelo conhecimento histórico, bem como, serve de base para pesquisas futuras.Palavras-chave: Colégio Agrícola; Memórias; Narrativas.
La construcción del sujeto complejo en la Educación Matemática Decolonial Transcompleja
Authors: Rodriguez Milagros Elena
Published: May 2021

El sujeto que deviene de la pedagogía de la matemática tradicional es soslayado; la escolaridad impone normas que establecen un orden y relaciones reproductivas que nos obliga a asimilar y repetir los saberes establecidos por la racionalidad hegemónica. En la concientización ecosófica, la ecosofía el arte de habitar en el planeta, propendemos la conformación del sujeto complejo en la Educación Matemática Decolonial Transcompleja como objetivo complejo de investigación. Se realiza la investigación desde la deconstrucción como transmétodo rizomático en la transmodernidad. En el rizoma reconstrucctivo, el sujeto concientizado critico en un dialogo dialéctico-dialógico, se conforma como ciudadano del planeta-tierra en la antropoética; desde la Educación Matemática. Es imperativo así, un des-ligar de las prácticas opresivas de la matemática; para re-ligar el sujeto político que ejerce un poder, que transita en el conocer la matemática compleja con el aporte de las civilizaciones colonizadas, en claros procesos decoloniales; y el hacer vida-cotidiana del habitat popular; en una liberación onto-epiestemológica del sujeto. Rompiendo la imposición Occidental de la matemática.
Detection of EEG-Based Eye-Blinks Using A Thresholding Algorithm
Authors: Tran Dang-Khoa , Nguyen Thanh-Hai , Nguyen Thanh-Nghia
Published: May 2021

In the electroencephalography (EEG) study, eye blinks are a commonly known type of ocular artifact that appears most frequently in any EEG measurement. The artifact can be seen as spiking electrical potentials in which their time-frequency properties are varied across individuals. Their presence can negatively impact various medical or scientific research or be helpful when applying to brain-computer interface applications. Hence, detecting eye-blink signals is beneficial for determining the correlation between the human brain and eye movement in this paper. The paper presents a simple, fast, and automated eye-blink detection algorithm that did not require user training before algorithm execution. EEG signals were smoothed and filtered before eye-blink detection. We conducted experiments with ten volunteers and collected three different eye-blink datasets over three trials using Emotiv EPOC+ headset. The proposed method performed consistently and successfully detected spiking activities of eye blinks with a mean accuracy of over 96%.
Role of Chitosan in Disease Suppression, Growth and Yield of Carrot
Authors: Rahman M. A. , Jannat R. , Akanda A. M. , Khan M. A. R. , Rubayet M. T.
Published: May 2021

An attempt was made for controlling of Rhizoctonia canker caused by Rhizoctonia solani and southern blight caused by Sclerotium rolfsii in pot and field experiments under inoculated condition and also to increase the growth promoting factors and yield of carrot through the application of chitosan. Before setting the experiments in the field, laboratory experiments were carried out to select virulent isolates of R. solani and S. rolfsii and effective dose of chitosan on mycelial growth inhibition of virulent isolates of test pathogens. In the pathogenicity test, R. solani isolate R-1 and S. rolfsii isolate S-1 were found to be the most virulent against carrot seedlings. In vitro application of 1.0% chitosan was found to inhibit 100% mycelial growth of both tested pathogens. The field experiment was laid out following randomized complete block design with four treatments, where no treatment was done in T1, pathogen was inoculated in T2 and seed treatment and soil amendment with 1.0% chitosan was done in T3 and T4, respectively, in pathogen inoculated condition. Application of 1.0% chitosan as seed treatment or soil amendment significantly reduced post-emergence seedling mortality, incidence of diseases and enhanced seedling growth and also yields of carrot. On the contrary, post-emergence seedling mortality, incidence of Rhizoctonia canker and southern blight of carrot were highest in treatment T2 where soil was inoculated with pathogens. Chitosan could be used as an alternative of fungicide to suppress Rhizoctonia canker and southern blight in sustainable agriculture and improvement the yield of carrot.
Competence of teachers of HEIS in the context of lifelong learning
Authors: Ridei Nataliia , Khomenko Oleksandr , Іvanenko Iryna , Filyanina Nelya , Poberezhets Hanna
Published: May 2021

The purpose of the academic paper is to reveal and define the set of competences of teachers of higher educational institutions, corresponding to the concept of “lifelong learning”. The study was conducted by surveying four higher educational institutions in Ukraine and Poland. Along with this, the basic components of the general competence of teachers of higher educational institutions are as follows: professional, psychological-communicative and academic competence. A set of certain features has been selected for a clear and concise essence of competences. It has been established that the competence of introduction of innovative learning technologies in the educational process, research, digital and competence of lifelong learning are relevant in accordance with the requirements. Systematization of indicators of professional, psychological-communicative and academic competence has made it possible to reveal that the improvement of these characteristics is achieved through continuous learning. It has been proved that the development of tools for assessing the competence teachers of higher educational institutions will help identify positive or negative trends.
Evaluating the impact of stand composition and competition on white spruce and aspen wood attributes in the boreal mixedwood
Authors:   , Jackalin Ryan
Published: May 2021

I evaluated how intra- and inter-specific competition affects the development of eleven wood attributes of trembling aspen (Populus tremuloides Michx.) and white spruce (Picea glauca (Moench) Voss) over 34 years. My analysis was conducted in a mixedwood trial site in Northern British Columbia, Canada, that included treatments consisting of 0, 1000, 2000, 5000, and 10000 stems per hectare of aspen. Competition was found to negatively influence wood attribute development in aspen and positively impact spruce (at low levels of competition). Plot level competition indices were the best predictor of variation in aspen wood attributes, while stand level competition (population density) best explained the majority of spruce wood attributes. Maintaining aspen at lower densities in intimate mixture can have a positive effect on spruce wood quality, while incurring relatively small reductions in spruce volume production and also retaining the ecological benefits associated with managing for mixed stands.
Analysis of specific heat of compressed gas fuel A and B combustion products in diesels
Authors: Sobolenko Anatoly Nikolaevich , Florianskaya Maria Vasilievna
Published: May 2021

The article underlines the interest to using gas fuel in diesel engines of the coastal fishing vessels. If the change to liquefied natural gas is limited by the lack of bunkering capabilities in the Russian ports, using compressed gas has become widespread in transport and in the household. A number of gas fueling stations are already available for this purpose. It seems reasonable to start the conversion of the port fleet to compressed gas from using the motor gas bottling equipment for that purpose. It is important to evaluate the change in engine performance parameters when converting to compressed gas. Compressed gas is a mixture of gases such as propane, ethane, butane, methane, etc. There is given the percentage of each gas content, according to GOST. The quantitative composition of the pure compressed gas combustion outcomes, as well as the gas ignited by the ignition diesel fuel was determined by the oxidation reactions of the chemical elements of which they consist, as well as by oxygen from air. As a result of regression analysis applied to define the properties of water vapor and gases, there have been derived linear and quadratic approximating dependences of the heat capacities of gases (CO2, N2) and water vapor (H2O) on temperature. There have been obtained the equations for determining the heat capacity of the combustion products of compressed gas for fuel grade A and B. There have been produced the formulas for determining heat capacity of pure combustion products of compressed gas ignited by the ignition diesel fuel. The obtained expressions are recommended to be used for analysis of the working cycle of a diesel engine running on the compressed gas.
Analysis of influence of elastic properties of deadwood bearings on shaft line operability
Authors: Khalyavkin Aleksey Aleksandrovich , Makeev Sergey Aleksandrovich , Loshadkin Dmitry Vladimirovich , Mamontov Victor Andreevich , Salameh Ali , Auslender Anna Yakovlevna
Published: May 2021

The paper considers the ship shafting and its design. Depending on the constructive features, operating conditions, effects of continuous, dynamic, variable and random loads the operation of the shaft line is accompanied by wear of the shafting structure and auxiliary parts. The formulas for calculating the maximum permissible clearances during operation in stern bearings of propeller shafts are given, according to the norms and technical and operational requirements. A graph of the maximum permissible clearances in metal stern bearings is presented. There has been carried out a dynamic design of the shaft line in order to define the influence of rigid characteristics of the stern bearings on eigen frequency of transverse vibrations. It is noted that the service life of the shaft line depends on the material of bushings or liners of the bearings (bakout, babbit, textolite, caprolon, bronze, polyurethanes, rubber) and their wear degree. The design scheme of the ship shaft line on elastic supports with a coefficient of rigidity is presented. To assess the influence of the elastic properties of deadwood bearings, the method of initial parameters was used. According to the researchers’ opinion, the greater the wear, the lower their stiffness coefficient. At a certain wear degree of deadwood bearings, there occurs resonance at the lowest operating frequencies. It has been proved that the greater the deflection at the attachment point of the propeller, the lower the eigen frequency of transverse vibrations of the shaft line. It has been pointed out that the calculations should include the separation of the shaft line from the deadwood bearing, since it contributes to a decrease in eigen frequency and causes a resonance during transverse vibrations.
Nuevas dinámicas familiares
Authors: Quilodrán Julieta , Castro Teresa
Published: May 2021

Hasta fines del siglo pasado los estudios dedicados al tema de la nup- cialidad y más ampliamente, a la formación de las uniones conyugales, habían puesto en evidencia la marcada estabilidad de este fenómeno.