bluuebunny/crossref_metadata_2025 huggingface dataset:
PERBEDAAN ASUPAN ENERGI, MAKRONUTRIEN, STATUS GIZI, DAN VO2 MAKS ANTARA ATLET SEPAK BOLA ASRAMA DAN NON ASRAMA
 [The Differences of Energy, Macronutrient Intake, Nutritional Status, and VO2 Max between Boarding and Non-Boarding Football Athletes]
Authors: Alfitasari Ayu , Dieny Fillah Fithra , Ardiaria Martha , Tsani A. Fahmi Arif
Published: February 2019

Football athletes require high-quality physical fitness that affects achievement. Nutritional status was the outcome of dietary intake and can influence physical fitness. Athletes who boarded have an organized eating arrangement, so the dietary intake is more assured. The objective of this study was to analyze the differences of energy, macronutrients intake, nutritional status, and V2 max between boarding and nonboarding football athletes aged 13 - 18 years. A cross-sectional study was done in 32 people who divided into two groups (boarding and non-boarding football athletes).The collected datas included food intake using 6x24 hoursfood recalls, height using microtoise, weight using digital scales, BMI for Age using WHO Anthro Plus, body fat percentage using Bioelectrical Impedance Analysis, VO2 max using Cooper Test 2.4 km. Nutrient values were analyzed using NutriSurvey. Statistical analysis using Independent TTest. There were significant differences between energy and macronutrient intake (p=0.001), body fat percentage (p=0.004), and VO2 max score (p=0.001) of boarding and non-boarding athletes. Energy and macronutrient intake of boarding and non-boarding athletes were still in the deficient category; however, the average nutritional intake of boarding athletes were still higher than non-boarding athletes. Most nutritional status of athletes based on BMI/Age were in normal category (87.5% in boarding athletes and 62.5% in non-boarding athletes). There was no over in non-boarding athlete. However, there were 12.5% of boarding athletes in the over fat category. 25% of non-boarding athletes were in the under fat category, while in boarding athletes, none of athlete in under fat category. 62.5% boarding athletes had VO2 max score at a very good level, while 87.5% of non boarding athletes were in enough category. There were significant differences between energy and macronutrient intake, body fat percentage, and VO2 max score between boarding and non-boarding football athletes.
PENGARUH INTERVENSI GIZI MULTIKOMPONEN PADA GURU, ORANG TUA DAN SISWA SEKOLAH DASAR TERHADAP PENGETAHUAN, SIKAP DAN KETERSEDIAAN BUAH SAYUR DI RUMAH
[Effect of Multicomponent Nutrition Intervention on Teachers, Parents, and Elementary School Students towards Knowledge, Attitude and Availability of Fruits and Vegetables at Home]
Authors: Haryana Nila Reswari , Kustiyah Lilik , Madanijah Siti
Published: February 2019

Consumption of fruits and vegetables in children is strongly influenced by several factors, such as lack of knowledge and attitude. However, eating behavior in children is also caused by the behavior of teachers and parents in eating fruits and vegetables which also influenced by knowledge and attitude. Therefore the purpose of this study was to analyze the effect of multicomponent nutrition intervention on teachers, parents, and elementary school students towards knowledge, attitude, and availability of fruits and vegetables at home. The design of this study was quasi-experimental. The intervention given to the subjects were nutritional education to three groups and giving fruits and vegetables in Nganjuk District, East Java in February-May 2017. Subjects were 10 teachers, 31 parents and 31 students. The data were analyzed by Friedman-test. After intervention, there was a significant increase of knowledge and attitude in teachers and (p=0.009) in students (p=0.000) and parents (p=0.000). Fruit availability at home increased significantly (p<0.05), on the other hand, vegetables availability not significantly increased. Involving teachers and parents were important in nutrition intervention for children. Increasing the availability of fruits and vegetables at home can increase children fruit consumption.
SUBSTITUSI SORGUM DAN UBI JALAR PUTIH PADA ROTI BAGEL SEBAGAI ALTERNATIF SELINGAN UNTUK PENDERITA DIABETES
[Substitution of Sorghum and White Sweet Potato on Bagels an Alternative Snack for Diabetics]
Authors: Ashfiyah Vina Nur
Published: February 2019

Bread is a favorite food for Indonesian people as an alternative snack or breakfast. Bagel is one of breads that gain popularity in Indonesia. Sorghum and white sweet potato as local staple foods could be used as substitute ingredients for decreasing the consumption of wheat flour and made a low glycemic index snacks that suitable for diabetics. The aim of this research was to analyze the effect of sorghum and white sweet potato substitution toward acceptability (color, aroma, taste, and texture), nutrient value (energy, carbohydrate, fat, protein, fiber) and the glycemic index of bagel. This research was an experimental study with Completely Randomized Design with 8 repetitions. There were one control formula (F0) and two substitute formulas, F1 (substitution with white sweet potato 20%), and F2 (substitution with white sweet potato 20% and sorgum 10%). The untrained panelists were 30 diabetics. The difference test was analyzed by Kruskall Wallis dan Mann Whitney with confidence level 95% (α≤0.05). The result showed that the most favorite formula was F1 and there were no significant differences among the formulas in color (p=0.360), aroma (p=0.940), taste (p=0.160), and texture (p=0.120). The nutrient value of F1 can fulfilled the nutritional requirement of diabetics snacks which contain, energy 85%, carbohydrate 99%, fat 40%, protein 92%, and fiber 260%. It also have low glycemic index (54.6), so it can be and alternative snack for diabetics.
Examining Social–Ecological Factors in Developing the Louisville Metro Department of Public Health and Wellness Syringe Exchange Program
Authors: Kerr Jelani , Atlas Melissa , Crabtree Wayne , Chen Yu-Ting , Moyer Sarah
Published: February 2019

Amid an opioid epidemic and increasing HIV and hepatitis C virus (HCV) concerns, the Louisville Metro Department of Public Health and Wellness developed syringe exchange programming (SEP) to reduce HIV and HCV transmission, increase linkage to health care, and provide health education to clients in Louisville, Kentucky. We describe organizational, community, and policy factors contributing to SEP development. Approximately 8000 clients received SEP services from June 2015 to December 2016. Coalition building, timely advocacy, and media engagement are integral to successful SEP development and uptake.
Antibiotic Prophylaxis in the Management of Open Fractures
Authors: Chang Yaping , Bhandari Mohit , Zhu Kan Lun , Mirza Reza Donald , Ren Melody , Kennedy Sean Alexander , Negm Ahmed , Bhatnagar Neera , Naji Faysal N. , Milovanovic Lazar , Fei Yutong , Agarwal Arnav , Kamran Rakhshan , Cho Sung Min , Schandelmaier Stefan , Wang Li , Jin Lin , Hu Shiyun , Zhao Yanping , Lopes Luciane Cruz , Wang Mei , Petrisor Brad , Ristevski Bill , Siemieniuk Reed A.C. , Guyatt Gordon H.
Published: February 2019

Background:

Evidence with regard to antibiotic prophylaxis for patients with open fractures of the extremities is limited. We therefore conducted a systematic survey addressing current practice and recommendations.

Methods:

We included publications from January 2007 to June 2017. We searched Embase, MEDLINE, CINAHL, the Cochrane Central Registry of Controlled Trials (CENTRAL), and the Cochrane Database of Systematic Reviews for clinical studies and surveys of surgeons; WorldCat for textbooks; and web sites for guidelines and institutional protocols.

Results:

We identified 223 eligible publications that reported 100 clinical practice patterns and 276 recommendations with regard to systemic antibiotic administration, and 3 recommendations regarding local antibiotic administration alone. Most publications of clinical practice patterns used regimens with both gram-positive and gram-negative coverage and continued the administration for 2 to 3 days. Most publications recommended prophylactic systemic antibiotics. Most recommendations suggested gram-positive coverage for less severe injuries and administration duration of 3 days or less. For more severe injuries, most recommendations suggested broad antimicrobial coverage continued for 2 to 3 days. Most publications reported intravenous administration of antibiotics immediately.

Conclusions:

Current practice and recommendations strongly support early systemic antibiotic prophylaxis for patients with open fractures of the extremities. Differences in antibiotic regimens, doses, and durations of administration remain in both practice and recommendations. Consensus with regard to optimal practice will likely require well-designed randomized controlled trials.

Clinical Relevance:

The current survey of literature systematically provides surgeons’ practice and the available expert recommendations from 2007 to 2017 on the use of prophylactic antibiotics in the management of open fractures of extremities.
Team Approach: Management of Scapholunate Instability
Authors: Kamal Robin N. , Moore Wendy , Kakar Sanjeev
Published: February 2019

* The wrist maintains stability through complex articulations of the carpal bones, dependent upon intrinsic and extrinsic ligaments.

* Injury to the scapholunate interosseous ligament may lead to dissociative carpal instability, abnormal carpal kinetics, and sometimes arthritis.

* The kinematics, kinetics, and self-stabilizing role of the tendons and their influence on the scapholunate interosseous ligament continue to be studied.

* Critical to successful treatment of scapholunate interosseous ligament injuries is timely and complementary therapy.

* There is currently no gold standard for a treatment algorithm for this condition.
О понятии доказательства
Authors: Кузина Е. Б.
Published: February 2019

Термин «доказательство» используется для обозначения целого спектра интеллектуальных процедур, направленных на установление объективной истины или обоснование истинности некоторого предложения, приемлемости императива, справедливости оценки, а также на убеждение других людей в его адекватности. В математике доказательство играет центральную роль, но вместе с тем общего понятия математического доказательства нет. Существует несколько весьма различных точек зрения на сущность математического доказательства, его цели, критерии и идеалы, и со временем эти критерии и идеалы меняются.

Доказательство в других науках рассматривается как процесс исследования, проверки и подтверждения некоторых положений с целью поиска и обоснования истины – объективной или конвенционально принятой. Здесь доказательство заключается главным образом в поисках подтверждающих свидетельств, их оценке и установлении того, что лучше всего они объясняются доказываемой гипотезой. Построение демонстрирующего рассуждения, которое и считается доказательством в дедуктивных науках, во многих других областях совсем не обязательно.

В разных областях познания критерии состоятельности и приемлемости доказательств различны. В одних – это формально-дедуктивная строгость, в других – очевидность аргументов, интуитивная ясность рассуждения, в третьих – достоверность и достаточность подтверждающих свидетельств.

Основным общим критерием приемлемости доказательства представляется его убедительность – способность вызвать у адресата такое принятие доказанного утверждения, что он готов убеждать в нем других. Доказательство всегда погружено в социально-исторический контекст, поэтому общего для всех наук и всех времен понятия доказательства не только не существует, но и не может существовать. DOI: 10.21146/2074-1472-2018-24-2-100-107
Логика и теория науки в философии XIX века
Authors: Черноскутов Ю. Ю.
Published: February 2019

В статье обсуждаются ключевые моменты и основные этапы развития программы, стремившейся свести теорию науки к (формальной) логике. Подобные проекты были несовместимы с некоторыми из основных принципов кантианской теории познания, поэтому развивались главным образом в рамках традиций, испытавших наименьшее влияние этой философии. Основное внимание уделяется истории развития этой программы в Австрии. Показано, что основные принципы этого подхода были заложены Б. Больцано, который отождествил проект «Wissenschaftslehre» с логикой. Анализируется своеобразие больцанистской концепции логической формы, в частности обращается внимание, что кантианское противопоставление содержанию для него не имеет отношения к сути дела. Далее рассматриваются особенности восприятия и развития лейбницевского проекта универсальной характеристики философами из круга Больцано – Ф. Экснером и Р. Циммерманном. В отличие от влиятельной интерпретации А. Тренделенбурга, эти авторы достаточно твердо и решительно увязывали этот проект с развитием формальной логики. Экснер фактически поставил задачу разработки чисто логического исчисления на основе больцановского метода вариации представлений; Циммерманн, среди прочего, предложил, что в качестве простейших понятий такого исчисления должны использоваться не те или иные категории, но средства выражения, с помощью которых из отдельных элементов строятся структуры знания. Рассматривается роль двух изданий учебника Р. Циммерманна «Формальная логика» для гимназий в утверждении соответствующих подходов. При этом мы пытаемся исследовать, за счет чего Циммерманн надеется достигнуть главной цели логики, которую он видит в том, что эта наука должна обеспечить единство научных методов и полное упорядочение научного знания. В заключение кратко прослеживается воплощение описанной программы в философских проектах А. Риля и Э. Гуссерля. DOI: 10.21146/2074-1472-2018-24-2-144-150
The Effects of Nonuniform Wettability and Heterogeneity on Induction Time and Onset of Spontaneous Imbibition
Authors: Føyen T. L. , Fernø M. A. , Brattekås B..
Published: February 2019

Spontaneous imbibition is a capillary-dominated displacement process in which a nonwetting fluid is displaced from a porous medium by the inflow of a more-wetting fluid. Decades of core-scale experiments have concluded that spontaneous imbibition occurs by a uniformly shaped saturation front with a rate that scales with the square root of time. The imbibition rate during early stages of spontaneous imbibition (the onset period) has been reported to deviate from the square-root-of-time behavior, although its effect on the imbibition process is not well-understood. Controlled-imbibition tests, presented in this paper, demonstrate that restricted wetting-phase flow during the onset period gives irregular saturation fronts and deviation from the square-root-of-time behavior. The deviation was caused by local variation in porosity and permeability or by a nonuniform wettability distribution, and was directly visualized or imaged by positron-emission tomography (PET). Without knowledge of local flow patterns, the development of irregular saturation fronts cannot be observed; hence, the effect cannot be accounted for, and the development of spontaneous imbibition might be erroneously interpreted as a core-scale wettability effect. Restricted wetting-phase flow at the inlet affects Darcy-scale wettability measurements, scaling, and modeling; our observations underline the need for a homogeneous wettability preference through the porous medium when performing laboratory spontaneous-imbibition measurements.
Reliability of pleth variability index in predicting preload responsiveness of mechanically ventilated patients under various conditions: a systematic review and meta-analysis
Authors: Liu Tianyu , Xu Chao , Wang Min , Niu Zheng , Qi Dun yi
Published: February 2019

Background: Goal-directed volume expansion is increasingly used for fluid management in mechanically ventilated patients. The Pleth Variability Index (PVI) has been shown to reliably predict preload responsiveness; however, a lot of research on PVI has been published recently, and new meta-analysis needs to be updated.
Methods: We searched PUBMED, EMBASE, Cochrane Library, Web of Science (updated to November 7, 2018) and the associated references. We also contacted relevant authors and researchers.
Results: Twenty-five studies with 975 patients were included in this meta-analysis. All patients were mechanically ventilated. The pooled area under the receiver operating characteristic (AUC) to predict preload responsiveness in patients was 0.82 (95% confidence interval (CI) 0.79 - 0.85). The pooled sensitivity was 0.77 (95% CI 0.67-0.85) and the pooled specificity was 0.77 (95% CI 0.71-0.82). The results of the without undergoing surgery subgroup (AUC =0.86, Youden index =0.65) and ICU subgroup (AUC =0.89, Youden index =0.67) were reliable.
Conclusion: The reliability of the PVI is limited, but the PVI can plays an important role in bedside monitoring for mechanically ventilated patients who are not undergoing surgery.
Keywords: Pleth variability index, Preload responsiveness, Mechanically ventilated patients, Meta-analysis.
Propionibacterium acnes-associated chronic hypertrophic pachymeningitis followed by refractory otitis media: A Case Report
Authors: Amano Eiichiro , Uchida Keisuke , Ishihara Tasuku , Otsu Shinichi , Machida Akira , Eishi Yoshinobu
Published: February 2019

Background: Hypertrophic pachymeningitis (HP) is a rare disorder that involves localized or diffuse thickening of the dura mater. HP is associated with various inflammatory, infectious, and malignant diseases, such as rheumatic arthritis, sarcoidosis, anti-neutrophil cytoplasmic antibody-associated vasculitis, IgG4-related disorders, syphilis, tuberculosis, bacterial and fungal infections, cancer, and idiopathic diseases, when evaluation fails to reveal a cause. Among them, chronic infection with Propionibacterium acnes is a rare etiology of HP, and its pathology remains unclear.
Case Presentation: An 80-year-old man having refractory otitis media with effusion of the right ear presented with progressive right-sided headache and nausea. Post-contrast brain magnetic resonance imaging revealed right mastoiditis and remarkable thickening of the dura mater and enhancement of pia mater extending from the right middle cranial fossa to the temporal lobe.
HP secondary to middle ear infection was suspected, and a biopsy of the right mastoid was performed. An anaerobic culture of the biopsied right mastoid showed the growth of P. acnes, and histopathological examination using P. acnes-specific monoclonal antibody (PAB antibody) revealed the infiltration of inflammatory cells with P. acnes. Moreover, using PAB antibody, P. acnes was detected in the biopsy specimen of the thickening dura mater. No granulomas were identified in either specimen. HP was resolved with long-term administration of antibiotics and steroids.
Conclusion: This is the first documentation of pathologically demonstrated chronic HP associated with P. acnes infection followed by refractory otitis media. This report showed that chronic latent P. acnes infection induces chronic inflammation, which cannot be controlled without administering steroids.
Keywords: Propionibacterium acnes, otitis media, pachymeningitis, mastoiditis, dura mater
Leukoencephalopathia, demyelinating peripheral neuropathy and dural ectasia explained by a not formerly described de novo mutation in the SAMD9L gene, ends 27 years of investigations – A case report
Authors: Thunström Sofia , Axelsson Markus
Published: February 2019

Background: Missense mutations in SAMD9L gene is associated with ataxia-pancytopenia syndrome (ATXPC), OMIM#159550. Common clinical features in these patients include neurological and hematological symptoms. The phenotype and age of onset is variable.
Case Presentation: In this case report whole exome sequencing (WES) revealed a not previously reported de novo variant c.2686T>G, p.(Phe896Val) in SAMD9L in a patient with widespread findings of slow developing pathology in the peripheral and central nervous system. The clinical picture was dominated by neurological symptoms, unlike previously described cases, and in addition dural ectasias and multiple cysts in the brain was observed using magnetic resonance imaging.
Conclusions: This case underscores the effect of variable expressivity, i.e. different mutations in the same gene can cause different phenotypes.
Keywords: Leukoencephalopathia, demyelinating peripheral neuropathy, dural ectasia explained, de novo mutation, the SAMD9L gene.
Greenhouse Production of Native Aquatic Plants
Authors: Gettys Lyn A. , Moore Kimberly A.
Published: February 2019

Wetland restoration is critical for improving ecosystem services, but many aquatic plant nurseries do not have facilities like those typically used for large-scale plant production. We questioned if we could grow littoral aquatic plant species in a variety of substrates and irrigation methods similar to those used for traditional greenhouse production. Plants were grown in pots with drainage holes that were filled with potting substrate, topsoil, coarse builders’ sand, or a 50/50 mix of topsoil and builders’ sand. These substrates were amended with 2 g of 15N–3.9P–10K controlled-release fertilizer per liter of substrate and were watered using either overhead irrigation or subirrigation. Plants were grown for 16 weeks, then scored for quality and height before a destructive harvest. Blue-eyed grass (Sisyrinchium angustifolium) and arrow arum (Peltandra virginica) performed best when subirrigated and cultured in potting substrate or sand. Golden club (Orontium aquaticum) and lemon bacopa (Bacopa caroliniana) grew best when plants were cultured in potting substrate and maintained under subirrigation. These experiments provide a framework for using existing greenhouses to produce these littoral species and give guidance to growers who wish to produce plants for the restoration market.
Challenges of improving effectiveness and efficiency of the higher educational system in developing countries
Authors: Al-Jaghoub Saheer , Samed Al-Adwan Ahmad , Al-Yaseen Hussein , Al-Soud Anas , Areiqat Ahmad
Published: February 2019

Due to the country’s lack of natural resources and its dependence on human resources, Jordanian universities have started to implement quality assurance system aiming to improve effectiveness and efficiency of the higher educational system. This paper presents the results of a research that aims to identify the main issues and challenges facing these universities in implementing quality assurance system. Data for this research were collected using a survey mailed to all public and private universities to investigate the main issues affecting the implementation of quality assurance system in Jordanian universities. The results of this research showed that the most important challenges faced by Jordanian universities are: human and lack of awareness, resistance to change and cultural among others. The research findings hoped to be useful for both universities and policy makers in the government in order to realize the full benefits of implementing quality assurance system. Hence, this and other research on implementing quality assurance in higher educational institutions might be of assistance.
A COMPETÊNCIA LEGISLATIVA EM MATÉRIA AMBIENTAL E O PRINCÍPIO DA PROPORCIONALIDADE
Authors: Costa Beatriz Souza , Doehler Ivan Dutra
Published: February 2019

Resumo

O objetivo do presente artigo é identificar os limites da competência legislativa do município em matéria ambiental, mediante a análise de uma decisão do STF que trata da exigência de complementação de estudos de impacto ambiental, por parte do município, como condição para a expedição de Certidão de Conformidade Ambiental. Tomando-se por base a teoria de Dworkin sobre o direito como integridade, bem como o princípio da proporcionalidade e o da ecoproporcionalidade, questiona-se a interpretação dos limites do interesse local na concessão do licenciamento ambiental e o ativismo judicial. Para tanto, utilizar-se-á o método hipotético-dedutivo baseado na pesquisa explicativa e qualitativa, com base na revisão bibliográfica, na legislação e na jurisprudência pátrias.

Palavras-chave: Competência legislativa do município no licenciamento ambiental. Hermenêutica. Princípio da proporcionalidade.
A INSUFICIÊNCIA DA CONSTITUIÇÃO DE 1988 PARA INSTITUIR UM ESTADO DEMOCRÁTICO DE DIREITO: UMA ANÁLISE EMPÍRICA DA DEMOCRACIA BRASILEIRA
Authors: Cavalcanti Gustavo , Rubião André
Published: February 2019

Objetiva-se neste artigo analisar de forma empírica a realização de paradigmas constitucionais de natureza democrática, relacionados à soberania popular e ao estado de direito, que permitem a instituição de um estado democrático de direito. Inicialmente abordar-se-á o significado teórico da adoção constitucional do paradigma do estado democrático de direito para, então, identificar de forma prática a realização deste paradigma na sociedade brasileira em relação a sociedades que já o fizeram. No contexto das pesquisas empíricas utilizadas identificamos lacunas que devem ser preenchidas para que o paradigma constitucional do estado democrático de direito possa ser realizado no cotidiano social brasileiro.
DESENVOLVIMENTO HUMANO E SUSTENTÁVEL NA PERSPECTIVA DA PESQUISA ACADÊMICA E NA ATUAÇÃO LEGISLATIVA
Authors: Bueno Wandscheer Clarissa , Dobrovolski Norberto Aline , Nanami Ayumi Stella
Published: February 2019

O presente artigo objetiva apresentar a atividade acadêmica e legislativa acerca do desenvolvimento sustentável e humano. Ou seja, se há um reflexo da pesquisa acadêmica e das preocupações levantadas com o que é produzido no legislativo federal. Para isso o procedimento metodológico adotado envolveu essencialmente um levantamento quantitativo de artigos científicos publicados em revistas indexadas pelo Qualis B2, B1, A2 e A1. E o levantamento legislativo a partir do material disponível no site oficial da Presidência da República. As buscas realizadas no ambiente acadêmico e legislativo envolveram as seguintes palavras-chave: desenvolvimento humano, desenvolvimento sustentável, sustentabilidade, meio ambiente, ambiente e cidades. Também há a preocupação em apresentar a problemática do desenvolvimento sustentável a partir dos Objetivos do Desenvolvimento Sustentável 2030 e considerações sobre o desenvolvimento humano como forma de identificar a relevância do tema e a necessidade de estar presente na agenda atual do governo e da sociedade. O presente trabalho está estruturado com uma discussão sobre a relação do desenvolvimento humano com a sustentabilidade e o meio ambiente; na segunda parte uma apresentação dos procedimentos metodológicos adotados para a pesquisa, na terceira parte a apresentação e discussão dos dados levantados nos ambientes acadêmico e legislativo, e; finalmente, as considerações finais e as referências utilizadas.
Physicochemical and bacteriological quality of sachet water used by Ghanaian university students: implications for public health
Authors: Addo Bismark Elorm , Amankwaa Godfred , Gyasi Razak M.
Published: February 2019

This study analyses the quality of sachet water consumed by university students in Metropolitan Kumasi, Ghana. Thirty sachet water samples from ten different brands were tested for their physical and bacteriological quality using meters and titrimetric method and most probable number method, respectively. Overall, one half of the sachet water samples were highly contaminated with total and faecal coliform. While the mean total coliform/100 mL concentration of ANG, NOV, IM, PD and DKN were 9.15 × 105, 2.35 × 106, 9.15 × 105, 4.15 × 105 and 9.15 × 105 respectively, we recorded faecal coliform counts of 2.3 × 105, 4.15 × 105, 2.3 × 105, 2.3 × 105 and 2.3 × 105, respectively for ANG, NOV, IM, PD and DKN. Moreover, samples from DKN brand showed Escherichia coli count of 4.0 × 104. The conductivity ranged from 2.24 μS/cm to 43.60 μS/cm while the mean total alkalinity of all samples ranged from 33.33 mg/L to 120 mg/L. The coliform contamination levels of the water samples violated the guidelines and standards of WHO for drinking water quality. Ghanaian regulatory agencies should intensify the monitoring and surveillance activities to ensure compliance with strict hygienic measures by sachet water producers.
The impacts of magnetized water treatment on different morphological and physiological factors of plant species in arid regions
Authors: Mohammadi R. , Dastorani M. T. , Akbari M. , Ahani H.
Published: February 2019

The aim of this study was to investigate the effects of magnetized water treatment (MWT) on some vegetation growth indices in arid areas of northeast Iran. For this purpose, the impacts of MWT were examined in terms of leaf area, special leaf area, and some of the physiographic indicators such as relative water capacity and foliar chlorophyll content in three species endemic to arid environments, namely Nitraria, Haloxylon, and Atriplex. In addition to the factors mentioned, acidity (pH) and electrical conductivity (EC) were also measured. This research was conducted in a completely randomized block design with three replications. Data analysis was carried out via the analysis of variance using MSTAT software. The results showed that species irrigated with magnetized water had better performance on measured growth indices. On average, the amount of increase for morphology and physiology parameters in the three species irrigated by MW (comparing with those irrigated by normal water) were: leaf development by 121.74 (19.59%), leaf area index (LAI) by 108.97 (17.5%) mm2, special leaf area (SAL) by 8.68%, relative water content (RWC) by 9.81%, and special product analysis division (SPAD) by 14.77%. The water magnetization process also reduced pH by 0.5 and EC by 0.3 μmhos.cm−1.
Experimental study of one- and two-cycle trapezoidal piano-key side weirs in a curved channel
Authors: Saghari Abolfazl , Saneie Mojtaba , Hosseini Khosrow
Published: February 2019

Piano-key weirs can be used instead of classic rectangular side-weirs (CRSWs) to increase the discharge capacity of side weirs. So far, no research has been done on trapezoidal piano-key side weirs (TPKSWs) in a curved channel. This study examines the effect of using one or two cycles in TPKSWs on discharge capacity, having the same total width and upstream–downstream length. Dimensional analysis has been performed to determine the dimensionless parameters affecting the discharge coefficient related to the developed length (CdL) of TPKSWs in a curved channel. An empirical equation for CdL has been proposed based on the experimental results. There is a good agreement between estimated and measured data. Results showed that the discharge coefficient related to the total width of a TPKSW is 1.7 to 5.6 times higher than that of a CRSW. Also, the CdL of a one-cycle TPKSW is 1.4 to 2 times higher than that of a two-cycle TPKSW.
A Similarity Searching System for Biological Phenotype Images Using Deep Convolutional Encoder-decoder Architecture
Authors: Wu Bizhi , Zhang Hangxiao , Lin Limei , Wang Huiyuan , Gao Yubang , Zhao Liangzhen , Chen Yi-Ping Phoebe , Chen Riqing , Gu Lianfeng
Published: February 2019

Background:

The BLAST (Basic Local Alignment Search Tool) algorithm has been
widely used for sequence similarity searching. Analogously, the public phenotype images must be
efficiently retrieved using biological images as queries and identify the phenotype with high
similarity. Due to the accumulation of genotype-phenotype-mapping data, a system of searching
for similar phenotypes is not available due to the bottleneck of image processing.

Objective:

In this study, we focus on the identification of similar query phenotypic images by
searching the biological phenotype database, including information about loss-of-function and
gain-of-function.

Methods:

We propose a deep convolutional autoencoder architecture to segment the biological
phenotypic images and develop a phenotype retrieval system to enable a better understanding of
genotype–phenotype correlation.

Results:

This study shows how deep convolutional autoencoder architecture can be trained on
images from biological phenotypes to achieve state-of-the-art performance in a phenotypic images
retrieval system.

Conclusion:

Taken together, the phenotype analysis system can provide further information on the
correlation between genotype and phenotype. Additionally, it is obvious that the neural network
model of image segmentation and the phenotype retrieval system is equally suitable for any
species, which has enough phenotype images to train the neural network.
Gene Selection Method for Microarray Data Classification Using Particle Swarm Optimization and Neighborhood Rough Set
Authors: Ye Mingquan , Wang Weiwei , Yao Chuanwen , Fan Rong , Wang Peipei
Published: February 2019

Background:

Mining knowledge from microarray data is one of the popular research
topics in biomedical informatics. Gene selection is a significant research trend in biomedical data
mining, since the accuracy of tumor identification heavily relies on the genes biologically relevant
to the identified problems.

Objective:

In order to select a small subset of informative genes from numerous genes for tumor
identification, various computational intelligence methods were presented. However, due to the
high data dimensions, small sample size, and the inherent noise available, many computational
methods confront challenges in selecting small gene subset.

Methods:

In our study, we propose a novel algorithm PSONRS_KNN for gene selection based on
the particle swarm optimization (PSO) algorithm along with the neighborhood rough set (NRS) reduction
model and the K-nearest neighborhood (KNN) classifier.

Results:

First, the top-ranked candidate genes are obtained by the GainRatioAttributeEval preselection
algorithm in WEKA. Then, the minimum possible meaningful set of genes is selected by
combining PSO with NRS and KNN classifier.

Conclusion:

Experimental results on five microarray gene expression datasets demonstrate that the
performance of the proposed method is better than existing state-of-the-art methods in terms of
classification accuracy and the number of selected genes.
Systems Biology Approaches Reveal a Multi-stress Responsive WRKY Transcription Factor and Stress Associated Gene Co-expression Networks in Chickpea
Authors: Konda Aravind K. , Sabale Parasappa R. , Soren Khela R. , Subramaniam Shanmugavadivel P. , Singh Pallavi , Rathod Santosh , Chaturvedi Sushil K. , Singh Narendra P.
Published: February 2019

Background:

Chickpea is a nutritional rich premier pulse crop but its production encounters
setbacks due to various stresses and understanding of molecular mechanisms can be ascribed foremost importance.

Objective:

The investigation was carried out to identify the differentially expressed WRKY TFs in chickpea
in response to herbicide stress and decipher their interacting partners.

Methods:

For this purpose, transcriptome wide identification of WRKY TFs in chickpea was done. Behavior
of the differentially expressed TFs was compared between other stress conditions. Orthology based cofunctional
gene networks were derived from Arabidopsis. Gene ontology and functional enrichment analysis
was performed using Blast2GO and STRING software. Gene Coexpression Network (GCN) was constructed
in chickpea using publicly available transcriptome data. Expression pattern of the identified gene
network was studied in chickpea-Fusarium interactions.

Results:

A unique WRKY TF (Ca_08086) was found to be significantly (q value = 0.02) upregulated not
only under herbicide stress but also in other stresses. Co-functional network of 14 genes, namely
Ca_08086, Ca_19657, Ca_01317, Ca_20172, Ca_12226, Ca_15326, Ca_04218, Ca_07256, Ca_14620,
Ca_12474, Ca_11595, Ca_15291, Ca_11762 and Ca_03543 were identified. GCN revealed 95 hub genes
based on the significant probability scores. Functional annotation indicated role in callose deposition and
response to chitin. Interestingly, contrasting expression pattern of the 14 network genes was observed in
wilt resistant and susceptible chickpea genotypes, infected with Fusarium.

Conclusion:

This is the first report of identification of a multi-stress responsive WRKY TF and its associated
GCN in chickpea.
Effect of Boswellia serrata on Rat Trachea Contractility In Vitro
Authors: Hewedy Wafaa Ahmed
Published: February 2019

Background:

Boswellia serrata (family Burseraceae) has been traditionally used for the
treatment of a wide variety of diseases as arthritis, inflammatory bowel diseases, and airway diseases.
However, the direct bronchodilator efficacy of Boswellia serrata hasn’t been explored yet.

Objective:

We aimed at the present study to evaluate the direct effect of Boswellia serrata extract
(BSE) on isolated rat tracheal preparations precontracted with either Acetylcholine (ACh) or potassium
chloride (KCl).

Methods:

Tracheal rings were prepared from male Wistar rats (200-250 g). BSE (1-200 μg/ml) was
added to tracheal strips precontracted with either ACh or KCl and the response was observed. We
also investigated the consequences of epithelial denudation, indomethacin, and N-Nitro-L-arginine
on the relaxant effect of BSE as compared to that of the β-adrenoceptor agonist isoprenaline, or the
bitter taste receptor (TAS2R) agonist denatonium benzoate. Finally, the possible additive effects of
BSE to isoprenaline or denatonium-induced relaxation were evaluated.

Results:

By using a set of serial dosing and washout experiments with tracheal rings, results showed
that exposure to BSE resulted into a significant and concentration-dependent inhibitory effect on
airway smooth muscle contractions precontracted with either ACh or KCl. Epithelial denudation, indomethacin,
or N-Nitro-L-arginine had no significant effect on the obtained relaxation. Furthermore,
BSE potentiated the relaxant effect of isoprenaline on rat trachea.

Conclusion:

BSE exerts a direct concentration-dependent relaxant effect on precontracted tracheal
strips. These results could contribute towards validation of the traditional use of BSE in the treatment
of airway diseases.
Recuperación de la estructura, diversidad y composición en una selva mediana subperennifolia en Yucatán, México
Authors: López-Jiménez Leonardo Noriel , Durán-García Rafael , Dupuy-Rada Juan Manuel
Published: February 2019

La selva mediana superennifolia es la comunidad más extendida y una de las más transformadas en la Península de Yucatán, sin embargo, existen pocos estudios sobre su proceso de recuperación. Este trabajo planteó analizar los patrones de recuperación de la estructura, diversidad y composición de especies en una selva de este tipo. El estudio se realizó en el área de conservación El Zapotal, en Yucatán, México, entre 2011 y 2012. Se muestreó la vegetación leñosa en una cronosecuencia de rodales, de 4 años a 60 años de abandono tras un uso ganadero, y en un remanente de selva conservada (madura). Los patrones de recuperación de la estructura y la diversidad con la edad sucesional se analizaron comparando diferentes modelos no lineales y los de composición mediante análisis de ordenación y de clasificación. Los atributos de la estructura y la diversidad aumentaron con la edad sucesional, excepto la densidad, que alcanzó un máximo en edades tempranas, seguido de una disminución. La diversidad alcanzó los valores observados en la selva conservada, pero la estructura no. La similitud florística con respecto a la selva madura aumentó con la edad de sucesión y se distinguieron tres grupos de especies que indican un recambio en la dominancia durante la sucesión. Los resultados sugieren una recuperación rápida de la diversidad, más lenta de la estructura, y un patrón sucesional de composición más semejante al de las selvas más húmedas que al de selvas más secas, con importantes implicaciones para la conservación, la restauración y la mitigación del cambio climático.
An Internet of Things Buttons to Measure and Respond to Restroom Cleanliness in a Hospital Setting: Descriptive Study (Preprint)
Authors: Chai Peter R , Zhang Haipeng , Jambaulikar Guruprasad D , Boyer Edward W , Shrestha Labina , Kitmitto Loay , Wickner Paige G , Salmasian Hojjat , Landman Adam B
Published: February 2019

BACKGROUND

Restroom cleanliness is an important factor in hospital quality. Due to its dynamic process, it can be difficult to detect the presence of dirty restrooms that need to be cleaned. Using an Internet of Things (IoT) button can permit users to designate restrooms that need cleaning and in turn, allow prompt response from housekeeping to maintain real-time restroom cleanliness.

OBJECTIVE

This study aimed to describe the deployment of an IoT button–based notification system to measure hospital restroom cleanliness reporting system usage and qualitative feedback from housekeeping staff on IoT button use.

METHODS

We deployed IoT buttons in 16 hospital restrooms. Over an 8-month period, housekeeping staff received real-time notifications and responded to button presses for restroom cleaning. All button presses were recorded. We reported average button usage by hospital area, time of day, and day of week. We also conducted interviews with housekeeping supervisors and staff to understand their acceptance of and experience with the system.

RESULTS

Over 8 months, 1920 requests to clean restrooms in the main hospital lobby and satellite buildings were received. The hospital lobby IoT buttons received over half (N=1055, 55%) of requests for cleaning. Most requests occurred in afternoon hours from 3 PM to midnight. Requests for cleaning remained stable throughout the work week with fewer requests occurring over weekends. IoT button use was sustained throughout the study period. Interviews with housekeeping supervisors and staff demonstrated acceptance of the IoT buttons; actual use was centered around asynchronous communication between supervisors and staff in response to requests to clean restrooms.

CONCLUSIONS

An IoT button system is a feasible method to generate on-demand request for restroom cleaning that is easy to deploy and that users will consistently engage with. Data from this system have the potential to enable responsive scheduling for restroom service and anticipate periods of high restroom utilization in a hospital.
Pharmacogenetics of Type 2 diabetes mellitus: A Systematic Review Protocol (Preprint)
Authors: Aghaei Meybodi Hamid Reza , Sarhangi Negar , Naghavi Anoosh , Rahbaran Marzieh , Hassani Doabsari Maryam , Nikfar Shekoufeh , Larijani Bagher , HASANZAD Mandana
Published: February 2019

UNSTRUCTURED

The objective of this systematic review is to determine the effect of genetic variants that associate with antidiabetic medications and their efficacy and toxicity in T2DM patients. The understanding may allow interventions for improving management of T2DM and later systematically evaluated in more in-depth studies. We will have performed a comprehensive search using PubMed, Scopus, EMBASE, Web of Sciences and Cochrane database from 1990 to 2018. Relevant journals and references of all included studies will be hand searched to find the additional studied. Eligible studies such as pharmacogenetics studies in terms of drug response and toxicity in the type 2 diabetes patients and performed just on human will be included. Data extraction and quality assessment will be carried out by two independent reviewers and disagreements will be resolved through third expert reviewer. Risk of bias will be assessed with the Cochrane Risk of Bias tool for randomized studies and Newcastle-Ottawa Scale (NOS) for observational Studies. Narrative synthesis will be conducted by the combination of key findings. The results of this study will be submitted to a peer-reviewed journal for publication and also presented at PROSPERO. We expect this review will provide highly relevant information for clinicians, pharmaceutical industry that will benefit from the summary of the best available data regarding the efficacy of antidiabetic medication in the aspect of pharmacogenetics. PROSPERO Registration number (CRD42018104843)
Pengembangan Pembelajaran Penulisan Kreatif Berwawasan Lingkungangan Bidang Bahasa dan Sastra Indonesia bagi Guru dan Siswa Pondok Pesantren Muqimus Sunnah di Palembang
Authors: Dewojati Cahyaningrum
Published: February 2019

One of the eﬀorts in supporting Sustainable Development Goals (SDGs) 2030 is noble moraleducation and environmental preservation through learning. In this case, creative writing is seen as an eﬀective learning medium to convey these values. Terefore, the development of environmentally sound creative writing study in the feld of language and Indonesian literature is considered necessary so that this community engagement activity is then implemented in Pondok Pesantren Muqimus Sunnah in Palembang. Te purpose of this community engagement is to improve the creativity of the community in the feld of creative writing that is environmentally sound as an eﬀort to support the Sustainable Development Goals (SDGs). Te method used in this community engagement is by delivering lectures on creative writing and training in both fction and nonfction. Games are also used as ways to covey the workshop materials. From this training, it seems that madrasah teacher and students are very enthusiastic and more eager to write. In conclusion, creative writing training that is embodied in games, as well as criticism of environmental conditions, is necessary to hone the criticality and creativity of the students and teachers in the world of literacy.
Manajemen Sejarah Berbasis Komunitas: Pengembangan Kawasan Kauman sebagai Living Museum
Authors: Setiawati Nur Aini
Published: February 2019

One of the community services developed by the Faculty of Cultural Sciences provides an assistance to the community of Kauman village in preparation for Kauman village development as Yogyakarta living museum. In this case, Kauman area will serve as a kind of village that has a sustainable cultural tradition since the founding of Ngayogyokarto Hadiningrat Sultanate. In accordance with the concept of the living museum, many kinds of ideas will be implemented to regain the old cultural traditions that were taken from interviews with Kauman elders, community fgures, and young people about the history of Kampung Kauman. Te interviews are basically an intangible heritage which its narrative was attached to the landscape of Kauman village. Te results obtained from the interviews is a collective memory of Kauman village society to the development history of Kauman village. Te compilation and determination of the location, the building, the narrative house of historical formation, and the tradition that is carried out regularly in one year is the initial basis for the implementation of the historical living museum.
La manipulación de los “precios de transferencia” y la fuga de capitales en Argentina, 2014
Authors: Grondona Verónica
Published: February 2019

La presente colaboración es una primera aproximación a la problemática de los precios de transferencia en Argentina, repasando la evolución de los cambios normativos en la materia; los distintos mecanismos avalados por la legislación para el cálculo de los precios de las operaciones intragrupo; la manera en que los mecanismos legales se convierten en vías para la elusión, evasión y fuga de capitales; los conflictos y resultados de los casos vinculados a precios de transferencia que han llegado a los tribunales en Argentina; y las recomendaciones de política imaginables en el presente contexto internacional y teniendo en cuenta algunas alternativas ensayadas por otros países.
Clinical study of the efficacy and safety of jamu for hyperuricemia
Authors: Triyono Agus , Novianto Fajar
Published: February 2019

Hyperuricemia is a degenerative disease with a reasonably high prevalence and requires long-term treatment. Clinical research has been conducted to test the efficacy and safety of herbal medicine for hyperuricemia. The research involved 30 subjects who had fulfilled the inclusion and exclusion criteria and conducted with a pre-post test research design. Subjects were treated with herbal medicine for hyperuricemia three times a day for 28 days. From the research, jamu for hyperuricemia was effective in reducing blood uric acid levels from 7.43 mg/dL to 5.72 mg/dL, raising the quality of life score (SF-36) from 78.06 to 81.50, and disappeared of clinical symptoms. Use of herbal medicine for hyperuricemia for 28 days in subjects had no symptoms of severe side effects found and did not interfere with liver, kidney, and blood function.