bluuebunny/crossref_metadata_2025 huggingface dataset:
Associations between media use, self-efficacy, and health literacy among Chinese rural and urban elderly: A moderated mediation model
Authors: Yu Yebo , Wu Yibo , Huang Zhen , Sun Xinying
Published: March 2023

Objectives

The influence of media use on health literacy among urban and rural elderly has been unknown in China. This study aims to examine the association between media use and health literacy and to explore the mediating role of self-efficacy and the moderating role of urban-rural residency.

Methods

Based on the cross-sectional study of the Psychology and Behavior Investigation of Chinese Residents (PBICR) in 2022, a total of 4,070 Chinese old people aged 60 years and above were included. We adopted the simplified New General Self-Efficacy Scale (NGSES) and the simplified Health Literacy Scale-Short Form (HLS-SF) to measure self-efficacy and health literacy. Media use was measured using a self-administrated questionnaire.

Results

Results showed that Chinese urban elderly had a higher frequency of media use than rural ones in the aspects of social activities, self-presentation, social action, leisure and entertainment, information acquisition, and business transactions through media (P < 0.001). Among all participants, self-presentation (B = 0.217, 95% CI: 0.040, 0.394), leisure and entertainment (B = 0.345, 95% CI: 0.189, 0.502), and information acquisition (B = 0.918, 95% CI: 0.761, 1.076) were significantly associated with health literacy. Self-efficacy partially mediated the effect of media use on health literacy (Bindirect = 0.045, 95% CI: 0.032, 0.058), accounting for 18.37% of the total effect. Urban-rural residency (B = 0.049, 95% CI: 0.024, 0.075) moderated the relationship between media use and self-efficacy significantly.

Conclusion

The urban-rural gap in health literacy requires more attention. The promotion of media use and self-efficacy may play a role in eliminating health disparities.

Limitations

As a cross-sectional study, it could not establish cause-effect relationships.
The efficacy and safety of complementary and alternative medicine in the treatment of nausea and vomiting during pregnancy: A systematic review and meta-analysis
Authors: Tan Mo-Yao , Shu Shi-Hong , Liu Run-Lei , Zhao Qian
Published: March 2023

Background

Complementary and alternative medicine (CAM) therapies are widely used for nausea and vomiting during pregnancy (NVP) due to the limitations of conventional medicine. However, their efficacy and safety remain controversial. Therefore, this meta-analysis was performed to assess the improvement of CAM therapy on NVP.

Methods

Randomized controlled trials (RCTs) were searched for where the trial group was CAM and the control group was a conventional medicine or a placebo for NVP. This was done via 8 databases, including PubMed, EMBASE, the Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wanfang, SinoMed, and VIP, from inception to October 25, 2022. The Grades of Recommendation, Assessment, Development and Evaluation (GRADE) was used to assess the quality of evidence. The Stata 15.0 software was used to perform the meta-analysis.

Results

Thirty-three RCTs were included in this study. The acupuncture treatment was superior to conventional medicine at the effective rate [RR = 1.71, 95% CI (1.02, 2.86), P = 0.042; Low-quality evidence]. Ginger had more significant effects than conventional medicine at the Rhodes index [WMD = −0.52, 95% CI (−0.79, −0.24), P ≤ 0.001; Moderate-quality evidence] and it had the same effect as drugs to relieve vomiting [SMD = 0.30, 95% CI (−0.12, 0.73), P = 0.160; Low-quality evidence]. Compared with placebo, ginger had a higher effective rate [RR = 1.68, 95% CI (1.09, 2.57), P = 0.018; Low-quality evidence], and lower Visual analog scale (VAS) of Nausea [WMD = −1.21, 95% CI (−2.34, −0.08), P = 0.036; Low-quality evidence]. Ginger had the same antiemetic effect as placebo [WMD = 0.05, 95% CI (−0.23, 0.32), P = 0.743; Low-quality evidence]. Acupressure was superior to conventional medicine at the reduction of antiemetic drugs [SMD = −0.44, 95% CI (−0.77, −0.11), P = 0.008; Low-quality evidence], and at the effective rate [RR = 1.55, 95% CI (1.30, 1.86), P ≤ 0.001; Low-quality evidence]. Acupressure had the same effect as placebo at the effective rate [RR = 1.25, 95% CI (0.94, 1.65), P = 0.124; Low-quality evidence]. Overall, CAM therapy was safer than conventional medicine or a placebo.

Conclusion

The results showed that CAM therapies were able to alleviate NVP. However, due to the low quality of existing RCTs, more RCTs with large sample sizes are needed to validate this conclusion in the future.
The clinical application of Chinese herbal medication to depression: A narrative review
Authors: Kang Dongyu , Dong Huixi , Shen Yidong , Ou Jianjun , Zhao Jingping
Published: March 2023

Depression severely impairs psychosocial functioning and quality of life, which places a huge burden on patients and their families. However, the physiological mechanism of depression remains unknown. Treatment with existing antidepressant medications is effective in around 50% of patients according to various studies, but is associated with severe side effects including nausea and headaches. Chinese herbal medicine (CHM) has been approved and widely used for depression as an alternative medicine in Chinese culture for decades. It has certain advantages and potential in the prevention and treatment of depression. In this review, we summarize the currently available evidence for the efficacy of CHM for the treatment of depression and physiological diseases comorbid with depression. We further discuss the possible mechanisms of action of CHM and the relationships to our current understanding of depression. The majority of current evidence has suggested that the combined treatment with CHM and mainstream antidepressants improves the response rate and reduces the side effects, while CHM alone could be more effective than placebo. However, the results should be carefully interpreted due to the shortcomings of existing clinical trials and a high risk of bias in meta-analyses. Our review provides a summary of the current applications and understanding of widely used CHMs for depression.
Characterization of interventional clinical trials for monkeypox; systematic review of ClinicalTrials.gov database
Authors: Alorfi Nasser M. , Alshehri Fahad S. , Haseeb Abdul
Published: March 2023

Background

Monkeypox (mpox), a zoonotic viral infection, poses a global threat that is being acknowledged at the national and international levels. This systematic review aims to identify and characterize interventional clinical trials for mpox.

Method

All interventional clinical trials registered at ClinicalTrials.gov for mpox were searched up to January 6, 2023. We described the characteristics of interventional clinical trials, and drug interventions (including drugs and vaccines).

Results

As of January 6, 2023, there were 10 clinical trials in the ClinicalTrials.gov registry that met our criteria. Most of the interventional clinical trials were focused on the treatment (N = 4, 40%) and prevention (N = 4, 40%) of mpox. From the 10 trials, 50% used random treatment allocation, and six (60%) chose the parallel assignment intervention model. All 10 studies were blinded, and six were open-label blinded. The largest proportion of the clinical trials (N = 4, 40%) were registered in Europe, followed by America (N = 3, 30%) and Africa and others (N = 3, 30%). The JYNNEOS vaccine (40%), followed by Tecovirimat (30%) were the most frequently studied drugs used against mpox.

Conclusion

A limited number of clinical trials have been registered on ClinicalTrials.gov since the first case of mpox was reported. Therefore, there is an urgent need to conduct large-scale randomized clinical trials to assess the safety and efficacy of the drugs and vaccines being used against the mpox virus.
The medium-term perceived impact of work from home on life and work domains of knowledge workers during COVID-19 pandemic: A survey at the National Research Council of Italy
Authors: Bodini Antonella , Leo Carlo Giacomo , Rissotto Antonella , Mincarone Pierpaolo , Fusco Stanislao , Garbarino Sergio , Guarino Roberto , Sabina Saverio , Scoditti Egeria , Tumolo Maria Rosaria , Ponzini Giuseppe
Published: March 2023

Objective

The study aimed to investigate perceptions and determinants of the overall impact on life and work domains among a community of knowledge workers after 18 months of forced work from home due to the pandemic.

Methods

A cross-sectional study with a retrospective assessment was conducted early in 2022 at the National Research Council of Italy. Five single-item questions explored the perceived impact on life domain while a 7-item scale the impact on the work domain. Bivariate analyses and multivariate regressions were used to evaluate the associations between impacts and some key factors defined by 29 ad hoc closed questions.

Results

More than 95% of the 748 respondents reported a perceived change in at least one item of the life domain. For each of these items, although a large group of subjects has reported that working from home had no impact (from 27 to 55%), in the rest of the sample the positive evaluation (from 30 to 60%) clearly prevailed over the negative one. Overall, most of the subjects (64%) rated the impact on the work experience positively. Relationship with colleagues and participation in the work context were the items where the greatest number of negative rates was concentrated (27 and 25%, respectively). On the other hand, positive perceptions prevailed over both negative perceptions and lack of impact perceptions on the subjects of organizational flexibility and quality of work. The frequency of work-room sharing, home-work commute time and changes in sedentary lifestyle, have been identified as common explanatory factors of perceived impacts on both domains.

Conclusion

Overall, respondents reported positive rather than negative perceived impacts of forced work from home in both their lives and work. The obtained results suggest that policies to promote the physical and mental health of employees, strengthen inclusion and maintain a sense of community are necessary to improve workers' health and prevent the effects of perceived isolation on research activities.
Effectiveness of travel behavior and infrastructure change to mitigate heat exposure
Authors: Li Rui , Chester Mikhail V. , Middel Ariane , Vanos Jennifer K. , Hernandez-Cortes Danae , Buo Isaac , Hondula David M.
Published: March 2023

Urban heat exposure is an increasing health risk among urban dwellers. Many cities are considering accommodating active mobility, especially walking and biking, to reduce greenhouse gas emissions. However, promoting active mobility without proper planning and transportation infrastructure to combat extreme heat exposure may cause more heat-related morbidity and mortality, particularly in future with projected climate change. This study estimated the effectiveness of active trip heat exposure mitigation under built environment and travel behavior change. Simulations of the Phoenix metro region's 624,987 active trips were conducted using the activity-based travel model (ABM), mean radiant temperature (TMRT, net human radiation exposure), transportation network, and local climate zones. Two scenarios were designed to reduce traveler exposure: one that focuses on built environment change (making neighborhoods cooler) and the other on travel behavior (switching from shorter travel time but higher exposure routes to longer travel time but cooler routes) change. Travelers experienced TMRT heat exposure ranging from 29°C to 76°C (84°F to 168°F) without environmental or behavioral change. Active trip TMRT exposures were reduced by an average of 1.2–3.7°C when the built environment was changed from a hotter to cooler design. Behavioral changes cooled up to 10 times more trips than changes in built environment changes. The marginal benefit of cooling decreased as the number of cooled corridors transformed increased. When the most traveled 10 km of corridors were cooled, the marginal benefit affected over 1,000 trips/km. However, cooling all corridors results in marginal benefits as low as 1 trip/km. The results reveal that heavily traveled corridors should be prioritized with limited resources, and the best cooling results come from environment and travel behavior change together. The results show how to surgically invest in travel behavior and built environment change to most effectively protect active travelers.
How the Nose Responds to SARS-CoV-2, Cell by Cell
Authors: Taliaferro Faith , Long Jaclyn M. , Ordovás-Montañés José
Published: March 2023

When people get infected with the SARS-CoV-2 virus, which causes COVID-19, why do some people get mildly sick while others get very sick? Although we know that SARS-CoV-2 enters the body via the nose and mouth, we do not fully understand how nasal cells respond to this infection or why some people get sicker than others. To answer these questions, we studied the immune response—the way the body fights infectious agents like bacteria and viruses—of cells from nasal swabs of healthy people and people with COVID-19. We found that nasal cells of very sick COVID-19 patients had a weaker immune response against the virus compared to that of cells from mildly sick patients, despite their virus levels being similar. Understanding how nasal cells interact with viruses and how their responses to infection are linked to how sick people get can help us better identify and manage the effects of viral infection.
Improving rowing performance by adjusting oar blade size and angle
Authors: van Nieuwburg W. C. A. M. , van Spreuwel B. J. J. , Tran M. T. K. , Yang M. D. , Greidanus A. , Mulder G. , Tummers M. J. , Westerweel J. , Suijker W. , van Wijk R.
Published: March 2023

The principal aim of the work presented here is to investigate and demonstrate that a forward tilted rowing blade would result in a more efficient and effective motion of the blade through the water that would result in a higher boat speed when an equal input power is provided. A 1:5 scaled rowing boat is used to determine the performance of rowing blades with different sizes and blade angles. This is used to validate the results of a previous study where the optimal blade angle of 15o with respect to the oar shaft was determined (
1). The input power and speed of the rowing boat can be compared between original and modified oar blades. Measurements in a towing tank demonstrate that a modified rowing blade result in faster rowing by 0.4% at the same input power. Maintaining the same stroke rate, the improvement of the blade efficiency is compensated by using a 4–6% increased blade area to yield the same input power.
Effects of dietary camelina, flaxseed, and canola oil supplementation on inflammatory and oxidative markers, transepidermal water loss, and coat quality in healthy adult dogs
Authors: Richards Taylor L. , Burron Scarlett , Ma David W. L. , Pearson Wendy , Trevizan Luciano , Minikhiem Debbie , Grant Caitlin , Patterson Keely , Shoveller Anna K.
Published: March 2023

Introduction

Camelina oil contains a greater concentration of omega-3 (n-3) a-linolenic acid (C18:3n-3; ALA) than omega-6 (n-6) linoleic acid (C18:2n-6; LA), in comparison to alternative fat sources commonly used to formulate canine diets. Omega-3 FAs are frequently used to support canine skin and coat health claims and reduce inflammation and oxidative stress; however, there is a lack of research investigating camelina oil supplementation and its effects on these applications in dogs. The objective of this study was to evaluate the effects of camelina oil supplementation on coat quality, skin barrier function, and circulating inflammatory and oxidative marker concentrations.

Methods

Thirty healthy [17 females; 13 males; 7.2 ± 3.1 years old; 27.4 ± 14.0 kg body weight (BW)] privately-owned dogs of various breeds were used. After a 4-week wash-in period consuming sunflower oil (n6:n3 = 1:0) and a commercial kibble, dogs were blocked by age, breed, and size, and randomly assigned to one of three treatment oils: camelina (n6:n3 = 1:1.18), canola (n6:n3 = 1:0.59), flaxseed (n6:n3 = 1:4.19) (inclusion level: 8.2 g oil/100 g of total food intake) in a randomized complete block design. Transepidermal water loss (TEWL) was measured using a VapoMeter on the pinna, paw pad, and inner leg. Fasted blood samples were collected to measure serum inflammatory and oxidative marker concentrations using enzyme-linked immunosorbent assay (ELISA) kits and spectrophotometric assays. A 5-point-Likert scale was used to assess coat characteristics. All data were collected on weeks 0, 2, 4, 10, and 16 and analyzed using PROC GLIMMIX in SAS.

Results

No significant changes occurred in TEWL, or inflammatory and oxidative marker concentrations among treatments, across weeks, or for treatment by week interactions. Softness, shine, softness uniformity, color intensity, and follicle density of the coat increased from baseline in all treatment groups (P < 0.05).

Discussion

Outcomes did not differ (P > 0.05) among treatment groups over 16-weeks, indicating that camelina oil is comparable to existing plant-based canine oil supplements, flaxseed, and canola, at supporting skin and coat health and inflammation in dogs. Future research employing an immune or exercise challenge is warranted, as the dogs in this study were not subjected to either.
Inside-out anal sacculectomy in small dog breeds and cats
Authors: Lee Sang Gwan , Jeong Seong Mok , Bae Sunhee , Park Yeonhee , Moon Changhwan , Kim Hee Young
Published: March 2023

This report describes a new, simple and rapid surgical technique for the removal of anal sac in small dogs and cats. The anal sacs were simply everted using mosquito hemostatic forceps and excised with the aid of an electrocautery surgical unit. On the evaluation of postoperative complications, only one dog of 28 animals experienced short-term minor complications of mild fecal incontinence and scooting. Thus, we suggest that this new surgical technique is easy, inexpensive and time-saving and some of the complications with previously reported methods used for small dog breeds and cats may be avoided by using this technique.
Complete genome sequence analysis of Edwardsiella tarda SC002 from hatchlings of Siamese crocodile
Authors: Rehman Muhammad Nafees Ur , Dawar Farman Ullah , Zeng Jifeng , Fan Lixia , Feng Wei , Wang Mengqi , Yang Nuo , Guo Guiying , Zheng Jiping
Published: March 2023

Edwardsiella tarda is a Gram-negative, facultative anaerobic rod-shaped bacterium and the causative agent of the systemic disease “Edwardsiellosis”. It is commonly prevalent in aquatic organisms with subsequent economic loss and hence has attracted increasing attention from researchers. In this study, we investigated the complete genome sequence of a highly virulent isolate Edwardsiella tarda SC002 isolated from hatchlings of the Siamese crocodile. The genome of SC002 consisted of one circular chromosome of length 3,662,469 bp with a 57.29% G+C content and four novel plasmids. A total of 3,734 protein-coding genes, 12 genomic islands (GIs), 7 prophages, 48 interspersed repeat sequences, 248 tandem repeat sequences, a CRISPR component with a total length of 175 bp, and 171 ncRNAs (tRNA = 106, sRNA = 37, and rRNA = 28) were predicted. In addition, the coding genes of assembled genome were successfully annotated against eight general databases (NR = 3,618/3,734, COG = 2,947/3,734, KEGG = 3,485/3,734, SWISS-PROT = 2,787/3,734, GO = 2,648/3,734, Pfam = 2,648/3,734, CAZy = 130/3,734, and TCDB = 637/3,734) and four pathogenicity-related databases (ARDB = 11/3,734, CARD = 142/3,734, PHI = 538/3,734, and VFDB = 315/3,734). Pan-genome and comparative genome analyses of the complete sequenced genomes confirmed their evolutionary relationships. The present study confirmed that E. tarda SC002 is a potential pathogen bearing a bulk amount of antibiotic resistance, virulence, and pathogenic genes and its open pan-genome may enhance its host range in the future.
Copper sulfate induces clinico-hematological, oxidative stress, serum biochemical and histopathological changes in freshwater fish rohu (Labeo rohita)
Authors: Naz Saima , Hussain Riaz , Guangbin Zhang , Chatha Ahmad Manan Mustafa , Rehman Zia Ur , Jahan Shfaq , Liaquat Momil , Khan Ahrar
Published: March 2023

Despite being an essential trace element for numerous metabolic processes and micronutrients, copper (Cu) has induced adverse effects on the environment and public health due to its continuous and widespread use for the last several decades. The current study assessed the hematological and histopathological alterations in the freshwater fish (Labeo rohita) exposed to graded concentrations of copper sulfate. For this purpose, L. rohita fish (n = 72), weighing ~200–215 g, were randomly divided into four experimental groups and then exposed to acute doses of CuSO4, i.e., control, 0.28, 0.42, and 0.56 μgL−1. For comparative analysis of hematological and biochemical changes, blood/serum samples were obtained on 12, 24, and 36 days. Overall, the body weight of fish decreased with the time and dose of CuSO4; as the dose increases, body weight decreases. Dose and time-dependent results were observed in other parameters also. Results showed a significant increase in leukocytes, whereas red blood cells count, Hb, and Hct were significantly reduced in treated groups compared to the control. The mean corpuscular hemoglobin (MHC) and mean corpuscular hemoglobin concentration (MCHC) showed a non-significant decrease in treated groups compared to the control group. Serum biochemical parameters, including total proteins, albumin, and globulin, decreased significantly (p < 0.05). At the same time, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), glucose, and cholesterol were significantly (p < 0.05) increased in the treated groups compared to the control group. Significantly (p < 0.05) increased levels of lipid peroxidation while decreased values of antioxidant enzymes, including superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (RGSH) in the blood of fish were recorded. Histopathological examination of fish gills, liver, and kidneys showed inflammation and degenerative changes due to CuSO4 exposure. In the brain tissue, degenerative changes like neuron necrosis, intracellular edema, cytoplasmic vacuolization, and congestion were observed. In conclusion, the study indicates that exposure to copper sulfate, even in smaller concentrations, can cause adverse hematological and histopathological changes in L. rohita fish.
Onboarding Handbook: An Indispensable Tool for Onboarding Processes
Authors: Godinho Teresa , Reis Isabel Pinto , Carvalho Rui , Martinho Filipa
Published: March 2023

Onboarding handbooks constitute a very important and powerful tool in the socialization and integration processes of recruits implemented by Human Resources. As companies compete to thrive in global markets, the attraction and retention of employees have been given much attention in recent years. One of the strategies developed by companies to achieve this goal are the so-called Onboarding Handbooks given to newcomers, serving as a means of facilitating workers’ integration into the everyday processes of the company. As a consolidated research area, many HR studies have been developed around these subjects, as these manuals have been proven to be important tools in the socialization process of the former candidate, now entering the organisational culture of a given enterprise. A literature review was developed according to the main variables of the study of Organisational Socialization processes, strategies, and methods, with special emphasis on the onboarding book. To find out if these manuals correspond to the relevant literature of HR, eight of the onboarding handbooks from several public and private organizations have been analysed following the proposed structure of onboarding handbooks presented in the literature review. In addition, purposeful sampling was followed and content analysis on the handbooks was developed. The paper’s contributions are twofold: (a) the authors suggest a complete and up-to-date structure for the contents of onboarding books to be applied by HR managers and (b) compare its structure to several manuals of different enterprises from various sectors of the Portuguese economy. Findings show that the onboarding book remains an important tool and facilitator of organisational integration. Although, the onboarding processes are changing, and even the format of the onboarding books can become different (digital or not), their contents are essential for the socialization of newcomers and a means to organisational culture dissemination as well as containing functional contents such as internal norms and regulations.
Modeling and Design Optimization of an Electric Environmental Control System for Commercial Passenger Aircraft
Authors: Planès Thomas , Delbecq Scott , Pommier-Budinger Valérie , Bénard Emmanuel
Published: March 2023

The aircraft environmental control system (ECS) is the second-highest fuel consumer system, behind the propulsion system. To reduce fuel consumption, one research direction intends to replace conventional aircraft with more electric aircraft. Thus, new electric architectures have to be designed for each system, such as for the ECS. In this paper, an electric ECS is modeled and then sized and optimized for different sizing scenarios with the aim of minimizing fuel consumption at the aircraft level. For the system and for each component, such as air inlets and heat exchangers, parametric models are developed to allow the prediction of relevant characteristics. These models, developed in order to be adapted to aircraft design issues, are of different types, such as scaling laws and surrogate models. They are then assembled to build a preliminary sizing procedure for the ECS by using a multidisciplinary design analysis and optimization (MDAO) formulation. Results show that the ECS design is highly dependent on the sizing scenario considered. An approach to size the ECS globally with respect to all the sizing scenarios leads to an ECS that accounts for around 200 N of drag, 190 kW of electric power, and 1500 kg of mass for the CeRAS aircraft.
Ice Accretion on Rotary-Wing Unmanned Aerial Vehicles—A Review Study
Authors: Muhammed Manaf , Virk Muhammad Shakeel
Published: March 2023

Ice accretion on rotary-wing unmanned aerial vehicles (RWUAVs) needs to be studied separately from the fixed-wing UAVs because of the additional flow complexities induced by the propeller rotation. The aerodynamics of rotatory wings are extremely challenging compared to the fixed-wing configuration. Atmospheric icing can be considered a hazard that can plague the operation of UAVs, especially in the Arctic region, as it can impose severe aerodynamic penalties on the performance of propellers. Rotary-wing structures are more prone to ice accretion and ice shedding because of the centrifugal force due to rotational motion, whereby the shedding of the ice can lead to mass imbalance and vibration. The nature of ice accretion on rotatory wings and associated performance degradation need to be understood in detail to aid in the optimum design of rotary-wing UAVs, as well as to develop adequate ice mitigation techniques. Limited research studies are available about icing on rotary wings, and no mature ice mitigation technique exists. Currently, there is an increasing interest in research on these topics. This paper provides a comprehensive review of studies related to icing on RWUAVs, and potential knowledge gaps are also identified.
Enhancing the Resolution of Blade Tip Vortices in Hover with High-Order WENO Scheme and Hybrid RANS–LES Methods
Authors: Shi Wenbo , Zhang Heng , Li Yuanxiang
Published: March 2023

The accurate prediction of blade tip vortices continues to be challenging for the investigation of rotor aerodynamics. In the current work, the blade tip vortex system of a Caradonna–Tung rotor in the hovering state is simulated on account of the framework of a high-order WENO scheme and hybrid RANS/LES method progressively. With the RANS method based on a fifth-order WENO–Roe scheme, the spatial resolution of wake age and capture the accuracy of tip vortices are improved significantly. However, the unsteadiness of the vortex system fails to be distinguished. Then, the DDES and IDDES methods, coupled with a fifth-order WENO–Roe scheme, are implemented to further enhance the resolution of the spatial turbulence. Compared with RANS, the improvement of spatial resolution is reflected in both the statistical and transient results with DDES. The identifiable vortex core distributions can be predicted at older wake ages. The asymmetrical characteristic of blade tip vortices is revealed along with the release of fluctuation while the predicted distribution of velocity profiles in the vortex core is enhanced. With the application of IDDES, the secondary turbulent structures are captured around the primary vortex core of blade tip vortices while the complex behaviors of the vortices are observed. However, the statistics of the averaged flow field are similar to DDES.
Irrigation Depth and Potassium Doses Affect Fruit Yield and Quality of Figs (Ficus carica L.)
Authors: Moura Elias Ariel , Mendonça Vander , Figueirêdo Vladimir Batista , Oliveira Luana Mendes , Melo Marlenildo Ferreira , Irineu Toni Halan Silva , Andrade Alex Danilo Monte , Chagas Edvan Alves , Chagas Pollyana Cardoso , Ferreira Enoch Souza , Mendonça Luciana Freitas Medeiros , Figueiredo Francisco Romário Andrade
Published: March 2023

The need to diversify agricultural production has fostered the cultivation of several crops under environmental conditions atypical to their origin, justifying the extreme importance of studies on the agricultural management of crops in semiarid regions. In this context, this study aimed to evaluate the effects of irrigation depth and potassium doses on fig quality under semiarid conditions. The experiment was conducted in a 4 × 4 split-split-plot design, in randomized block design, with three replicates. The plots corresponded to four irrigation levels (50%, 75%, 100%, and 125% ETc), the subplots consisted of four potassium doses (0, 60, 120, and 240 g K2O plant−1), and the sub-subplot corresponded to the crop years (2018/19 and 2019/20). Results showed that water deficit reduced fig productivity, and the irrigation levels equal to or greater than 100% ETc performed cumulatively throughout the growing cycles. Therefore, irrigation depths from 85.19% to 95.16% ETc are recommended for greater water-use efficiency and fruit quality. Furthermore, potassium fertilization mitigated water stress in fig plants, allowing for reduced irrigation levels, especially in the second year, without compromising fruit traits.
Estimation of Winter Wheat Canopy Chlorophyll Content Based on Canopy Spectral Transformation and Machine Learning Method
Authors: Chen Xiaokai , Li Fenling , Shi Botai , Fan Kai , Li Zhenfa , Chang Qingrui
Published: March 2023

Canopy chlorophyll content (CCC) is closely related to crop nitrogen status, crop growth and productivity, detection of diseases and pests, and final yield. Thus, accurate monitoring of chlorophyll content in crops is of great significance for decision support in precision agriculture. In this study, winter wheat in the Guanzhong Plain area of the Shaanxi Province, China, was selected as the research subject to explore the feasibility of canopy spectral transformation (CST) combined with a machine learning method to estimate CCC. A hyperspectral canopy ground dataset in situ was measured to construct CCC prediction models for winter wheat over three growth seasons from 2014 to 2017. Sensitive-band reflectance (SR) and narrow-band spectral index (NSI) were established based on the original spectrum (OS) and CSTs, including the first derivative spectrum (FDS) and continuum removal spectrum (CRS). Winter wheat CCC estimation models were constructed using univariate regression, partial least squares (PLS) regression, and random forest (RF) regression based on SR and NSI. The results demonstrated the reliability of CST combined with the machine learning method to estimate winter wheat CCC. First, compared with OS-SR (683 nm), FDS-SR (630 nm) and CRS-SR (699 nm) had a larger correlation coefficient between canopy reflectance and CCC; secondly, among the parametric regression methods, the univariate regression method with CRS-NDSI as the independent variable achieved satisfactory results in estimating the CCC of winter wheat; thirdly, as a machine learning regression method, RF regression combined with multiple independent variables had the best winter wheat CCC estimation accuracy (the determination coefficient of the validation set (Rv2) was 0.88, the RMSE of the validation set (RMSEv) was 3.35 and relative prediction deviation (RPD) was 2.88). Thus, this modeling method could be used as a basic method to predict the CCC of winter wheat in the Guanzhong Plain area.
Long-term Tillage Alters Soil Properties and Rhizosphere Bacterial Community in Lime Concretion Black Soil under Winter Wheat–Summer Maize Double-Cropping System
Authors: Sun Qing , Zhang Peiyu , Liu Xiang , Zhang Hongsheng , Liu Shutang , Sun Xuefang , Jiang Wen
Published: March 2023

Tillage practices can directly affect soil quality, influencing soil properties, crop growth, and soil microbial community characteristics. However, the influence of long-term tillage practices on the rhizosphere bacterial community in lime concretion black soil remains largely unknown. In this study, the effects of nine-year rotary tillage (RT), no-tillage (NT), subsoiling tillage (ST), and plow tillage (PT) on soil chemical properties, microbial community structure, and correlations between bacterial communities and soil properties in the maize rhizosphere were investigated. The results revealed that the maize yield in ST and PT was higher by 10.61% and 10.26% than that in RT and by 10.25% and 9.90% than that in NT, respectively. The soil organic matter (SOM) and total nitrogen (TN) contents in NT and ST were significantly higher than those in RT and PT, whereas the available phosphorus (AP) content in ST and PT was significantly higher than that in NT and RT. The diversity and richness of the soil bacterial communities exhibited a trend of NT > RT > PT > ST. The principal component analysis revealed that the soil bacterial community differed among treatments. Linear discriminant analysis effect size (LEfSe) analysis demonstrated that Proteobacteria, Armatimonadetes, Verrucomicrobia, and Chloroflexi could serve as crucial biomarkers. Phylogenetic investigation of communities by reconstruction of unobserved states (PICRUSt) results revealed that genes involved in carbon, lipid, and xenobiotic metabolism were enriched under ST and PT, whereas those involved in nitrogen and carbon fixation were enriched under NT. Besides, Proteobacteria, Verrucomicrobia, and Armatimonadetes were positively associated with AP levels and negatively associated with pH; however, Acidobacteria, Bacteroidetes, and Planctomycetes exhibited an opposite trend. Overall, ST and PT improved the soil properties and environmental suitability by increasing the bacterial keystone taxa; thus, these practices improved crop yield. These findings could enhance our understanding of the rhizosphere functional microbial community in lime concretion black soil for winter wheat–summer maize double-cropping system.
Effect of Presowing Magnetic Field Stimulation on the Seed Germination and Growth of Phaseolus vulgaris L. Plants
Authors: Pszczółkowski Piotr , Sawicka Barbara , Skiba Dominika , Barbaś Piotr , Krochmal-Marczak Barbara , Ahmad Mohammad Ayaz
Published: March 2023

Background: The problem of the influence of magnetic fields (FMs) on the growth and development of common bean plants is still far from being fully explained due to its complicated physical nature and the geometry of the seeds. FMs can practically penetrate through living organisms. Aim: The present work aimed to determine the effect of the presowing FM stimulation of common bean seeds on plant growth and development elements. Material and Methods: The present study was based on a field experiment carried out between the years 2015 and 2017 in Żyznów (N 49°81′, E 21°84′, 239 m above sea level). The experiment was carried out using three repetitions of the randomized block method. The experimental factor was the amount of exposure to FM seed stimulation: (I) 15 s, (II) 30 seconds, and (III) the control object without seed stimulation. The plant material of the study was a common bean: cv. Gold Saxa. Results: The biostimulation of the sources with an FM improved the germination energy, strength, and capacity of the seeds. The presowing FM stimulation of the common bean seeds favourably affected the fresh weight of the first and fifth leaves but did not affect their dry weight. The leaves’ collection dates measured the new first and fifth plates and their dry weight content. The collection dates of the leaves determined the level of the fresh weight of the first and fifth leaves and the content of their dry weight. Conclusions: The biostimulation of the seeds with the FM contributed to a higher germination capacity, energy, and strength of the common bean seeds. The highest level of the leaves’ fresh weight was achieved during full flowering, and the highest dry matter content of the leaves was found in the phase of pod setting.
Evaluation and Screening of Rapeseed Varieties (Brassica napus L.) Suitable for Mechanized Harvesting with High Yield and Quality
Authors: Li Qin , Luo Tao , Cheng Tai , Yang Shuting , She Huijie , Li Jun , Wang Bo , Kuai Jie , Wang Jing , Xu Zhenghua , Zhou Guangsheng
Published: March 2023

Improving seed yield and quality and optimizing plant architecture to adapt to mechanized harvesting are essential strategies for rapeseed industry development in the Yangtze River basin. The present study selected 24 elite rapeseed varieties from the middle region of the Yangtze River basin as materials to investigate the growth period, plant architecture characteristics, lodging resistance, yield, and seed quality across 2 growing seasons. The results showed that plant biomass, silique number per plant, and seed yield showed a significant positive correlation with each other. A high plant growth rate was the prerequisite for early maturity varieties to achieve high yield. The path analysis illustrated that plant architecture can directly affect the seed yield (direct path efficiency = 0.17) or indirectly affect the yield through lodging (indirect path efficiency: −0.37 × 0.30 = −0.11). Therefore, modifying the plant architecture needs to balance the tradeoff between seed yield and lodging. The comprehensive performance of selected genotypes was evaluated by combining D-CRITIC (Distance-based inter-criteria correlation) and membership function methods. From the comprehensive performance across two cropping seasons, the varieties V24, V23, V22, V21, V12, V17, V19, and V20 had substantial potential for mechanized harvesting with high yield and good seed quality. These results provide a theoretical basis for farmers’ decisions and breeding of rapeseed suitable for mechanized harvesting in the Yangtze River basin.
The Colonization of Rumen Microbiota and Intervention in Pre-Weaned Ruminants
Authors: Li Kenan , Shi Binlin , Na Renhua
Published: March 2023

In pre-weaned ruminants, the microbiota colonizes rapidly in the rumen after birth and constantly interacts with the host to sustain health and metabolism. The developing microbial community is more malleable, so its manipulation may improve ruminant health and productivity as well as may have long-term effects on ruminants. Hence, understanding the process of rumen microbiota establishment is helpful for nutritional interventions of rumen microbiota in pre-weaned ruminants. This paper reviews the latest advances in the colonization of rumen microbiota while providing insights into the most suitable time for manipulating rumen microbial colonization in early life. In addition, different factors that affect rumen microbiota establishment during the pre-weaned ruminants are discussed in the current manuscript. The purpose of this review is to aid in the development of guidelines for manipulating rumen microbiota to improve animal productivity and health.
The Anti-Biofilm Potential of Linalool, a Major Compound from Hedychium larsenii, against Streptococcus pyogenes and Its Toxicity Assessment in Danio rerio
Authors: Praseetha Sarath , Sukumaran Swapna Thacheril , Dan Mathew , Augustus Akshaya Rani , Pandian Shunmugiah Karutha , Sugathan Shiburaj
Published: March 2023

The anti-biofilm and anti-virulence potential of the essential oil (E.O.) extracted from Hedychium larsenii M. Dan & Sathish was determined against Streptococcus pyogenes. A crystal violet assay was employed to quantify the biofilm. Linalool, a monoterpene alcohol from the E.O., showed concentration-dependent biofilm inhibition, with a maximum of 91% at a concentration of 0.004% (v/v). The AlamarBlueTM assay also confirmed Linalool’s non-bactericidal anti-biofilm efficacy (0.004%). Linalool treatment impeded micro-colony formation, mature biofilm architecture, surface coverage, and biofilm thickness and impaired cell surface hydrophobicity and EPS production. Cysteine protease synthesis was quantified using the Azocasein assay, and Linalool treatment augmented its production. This suggests that Linalool destabilizes the biofilm matrix. It altered the expression of core regulons covRS, mga, srv, and ropB, and genes associated with virulence and biofilm formation, such as speB, dltA, slo, hasA, and ciaH, as revealed by qPCR analysis. Cytotoxicity analysis using human kidney cells (HEK) and the histopathological analysis in Danio rerio proved Linalool to be a druggable molecule against the biofilms formed by S. pyogenes. This is the first report on Linalool’s anti-biofilm and anti-virulence potential against S. pyogenes.
Monensin, an Antibiotic Isolated from Streptomyces Cinnamonensis, Regulates Human Neuroblastoma Cell Proliferation via the PI3K/AKT Signaling Pathway and Acts Synergistically with Rapamycin
Authors: Serter Kocoglu Sema , Secme Mücahit , Oy Ceren , Korkusuz Gözde , Elmas Levent
Published: March 2023

Neuroblastoma is the most common extracranial childhood tumor and accounts for approximately 15% of pediatric cancer-related deaths. Further studies are needed to identify potential therapeutic targets for neuroblastoma. Monensin is an ionophore antibiotic obtained from Streptomyces cinnamonensis with known antibacterial and antiparasitic effects. No study has reported the effects of monensin on SH-SY5Y neuroblastoma cells by targeting the PI3K/AKT signaling pathway. The aim of this study was to investigate the antiproliferative effects of monensin alone and in combination with rapamycin in human SH-SY5Y neuroblastoma cells mediated by the PI3K/AKT signaling pathway. The effects of single and combination applications of monensin and rapamycin on SH-SY5Y cell proliferation were investigated by XTT, and their effects on the PI3K/AKT signaling pathway by RT-PCR, immunohistochemistry, immunofluorescence, and Western blotting. The combined effects of monensin and rapamycin on SH-SY5Y proliferation were most potent at 72 h (combination index < 1). The combination of monensin and rapamycin caused a significant decrease in the expression of P21RAS, AKT, and MAPK1 genes. Single and combined administrations of monensin and rapamycin caused a significant decrease in PI3K/AKT expression. Our results showed for the first time that monensin exerts an antiproliferative effect by targeting the PI3K/AKT signaling pathway in neuroblastoma cells. It is suggested that monensin and its combination with rapamycin may be an effective therapeutic candidate for treating neuroblastoma.
Safe Functional Modified CuO Nanoparticles?
Authors: Reijnders L.
Published: March 2023

CuO nanoparticles produced by methods from inorganic chemistry and physics are applied as biocides and applications thereof in solar stills, solar collectors, catalysis, sensing and diesel fuels have been proposed. Such CuO nanoparticles are hazardous due to the release of Cu ions and the induced generation of reactive oxygen species after uptake by organisms. Nanoparticle hazard may be reduced by surface modification (coating or capping) and doping which reduces the release of Cu ions and the generation of reactive oxygen species. None of the published safe-by-design modifications of CuO nanoparticles that will be discussed here have been proven safe (no risk). By targeting the release of Cu ions and the generation of reactive oxygen species by CuO nanoparticles, safe(r)-by-design studies target properties that underly the biocidal functionality of CuO nanoparticles. Other functionalities of CuO nanoparticles may also be impacted. There is a case for complementing safe(r)-by-design studies by investigating the impact of the modifications studied on CuO nanoparticle functionality.
A Trajectory Generation Method for Multi-Rotor UAV Based on Adaptive Adjustment Strategy
Authors: Wang Kaipeng , Meng Zhijun , Wang Zichen , Wu Zhenping
Published: March 2023

In order to fly safely and autonomously in complex environments, UAVs need to be able to plan their trajectories in real-time. This paper proposes an improved B-spline-based trajectory generation method that can generate safe, smooth, and kinodynamically feasible trajectories in real-time. This paper firstly introduces the principle of error upper bound of the B-spline curve and proposes a new trajectory safety assurance method; then, the loss function of trajectory is constructed based on safety, smoothness, and flight time; finally, a parameter adaptive trajectory optimization method is proposed, so that obtain the safe trajectory. Compared with the existing methods, the proposed method has two important improvements: (1) it solves the problem of overly conservative safety distance estimation at control points, improves the trajectory smoothness, and reduces the required flight time; (2) it proposes a trajectory optimization method with adaptive adjustment of safety distance parameters, which improves the quality and success rate of the planned trajectory. We validate our proposed method in simulation and real-world tasks, and the test results show that the method proposed in this paper can significantly improve the quality of the generated trajectory.