bluuebunny/crossref_metadata_2025 huggingface dataset:
BENEFÍCIOS DA UTILIZAÇÃO DA SÁLVIA NA AROMATERAPIA E SEU USO CONTRA A ANSIEDADE: UMA REVISÃO
Authors: Dechechi Thaynara Knopik , Baretta Irinéia Paulina
Published: October 2022

A aromaterapia, de acordo com referenciais como Machado e Fernandes Junior (2011), vem ganhando espaço significativo na área da saúde, possuindo diversas propriedades benéficas aos seres humanos quando utilizada de forma correta e adequada, sendo a sálvia um dos compostos naturais empregados por ela. A sálvia, além das propriedades para a saúde física, apresenta benefícios para aspectos de âmbito emocional, incluindo-se a ansiedade, origem de transtornos muito presentes na vida das pessoas. O objetivo do presente estudo consiste em realizar um levantamento bibliográfico sobre a utilização da sálvia na aromaterapia, sobre seus benefícios tanto para a saúde física, quanto para a saúde mental dos indivíduos, principalmente contra a ansiedade. Conclui-se neste trabalho que a sálvia quando utilizada na aromaterapia possui um papel importante contra a ansiedade, além de outros vieses físicos, auxiliando o paciente em uma visão holística, de modo integral, podendo contribuir também para o progresso dos sistemas de saúde.
ELABORATION OF GUIDELINE FOR MONITORING IN RELATIVE BIOAVAILABILITY / PHARMACEUTICAL BIOEQUIVALENCE STUDY BY THE SPONSOR
Authors: Gozzi Paula Thais , Bueno Fernanda Giacomini , Zimmermann Patrícia Moura da Rosa , Junior Liberato Brum
Published: October 2022

For registration of generic and similar drugs, it is necessary to carry out pharmaceutical equivalence (PE) tests and pharmaceutical bioequivalence (PB). To carry out these tests, duly qualified research centers are contracted, which need to be monitored by the sponsor who is legally responsible for the activities. To this end, it is the recommendation of the Document of the Americas, periodic monitoring to verify compliance with quality requirements, Standard Operating Procedures, Good Clinical Practices (GCP), Good Laboratory Practices (GLP), of the applicable regulatory framework, as well as of compliance with the study protocol. Thus, monitoring is a methodical and documented process to evaluate the degree of adhesion of the center to the planned design for the evaluation of the formulations. To this end, the implementation of a standardized and easily completed guideline is a very important tool to guarantee a consistent evaluation and maintain the organizational memory of the evaluated items by monitors designated by the sponsor, contributing to the constant improvement of the contracted centers and supporting traceability of the studies. This work provided a systemic view of the evidence process related mainly to pharmaceutical bioequivalence, with the monitoring guideline summarizing the items of greatest relevance to be verified.
PERFIL CLÍNICO-EPIDEMIOLÓGICO DE PACIENTES DIAGNOSTICADOS COM HANSENÍASE
Authors: De Oliveira Grazziela Souza Pinheiro , Barbosa Arlan Cardec , Carrijo Marcos Vítor Naves
Published: October 2022

A hanseníase no Brasil ainda apresenta como um problema de saúde pública. A posição epidemiológica da doença no país é considerada diversificada devido ao alto coeficiente e variação de prevalência nas diversas regiões do país. O objetivo desse estudo é conhecer o perfil epidemiológico da população acometida pela hanseníase na cidade de General Carneiro, no interior do Mato Grosso, durante os anos de 2006 e 2021. A coleta de dados foi realizada nos meses de julho e agosto do ano de 2021. Trata-se de uma pesquisa retrospectiva, documental do tipo descritiva, com abordagem quantitativa. No período em estudo notificou-se 50 casos, sendo 62% do sexo masculino, com faixa etária entre 48 a 69 anos de idade, de cor branca, com predominância da forma dimorfa. Os resultados demonstram que a cidade de General Carneiro, está com o número de casos de hanseníase na média do preconizado pela Organização Mundial de Saúde e também, inferior à média brasileira.
BUMETANIDE IN AUTISM SPECTRUM DISORDER
Authors: Moreira Lucas da Silva , Aragão Gislei Frota
Published: October 2022

Objectives: This study aimed to make a bibliographic update on the already published data on bumetanide, addressing the main information on its use in Autism Spectrum Disorder (ASD).  Methods: This was an integrative narrative review in which the following databases were used: Web of Science, MEDLINE, ScienceDirect, and Scielo. The descriptors used were: Autism Spectrum Disorder, Autistic Disorder and Bumetanide. It was considered only articles published in English and French. Original articles, randomized clinical trials, case reports, and review articles were included. Results: The results show that the use of bumetanide alters regions of the brain linked to the positive development of language, improvement of visual contact, improvement in social interactions, among others. Studies are also concerned about the safety and efficacy of bumetanide in ASD since several adverse effects have been reported. The most frequent were hypokalemia, polyuria, and loss of appetite. Conclusion: Bumetanide has proven as effective in improving some important symptoms in ASD, especially linked to language and social interaction, however, studies with larger groups of patients and with longer treatment and observation time are needed to confirm the efficacy and clarify the safety profile in use for people with ASD.
VALIDAÇÃO DO INSTRUMENTO DE CUIDADO DO ENFERMEIRO AO PACIENTE CRÍTICO COM CATETER VENOSO CENTRAL
Authors: Jesus Stefhanie Conceição de , Bertoncello Kátia Cilene Godinho , Gonçalves Fernanda Alves Ferreira , Colaço Aline Daiane , Costa Diovane Ghignatti da
Published: October 2022

Objetivo: Validar o conteúdo do instrumento de cuidado do enfermeiro ao paciente com cateter venoso central, internado na unidade de terapia intensiva. Métodos: Estudo quantitativo, conduzido em duas etapas: análise teórica por sete enfermeiros especialistas, dos itens do instrumento construído anteriormente e análise estatística a partir do Índice de Validade de Conteúdo e o coeficiente Alpha de Cronbach. Resultados: Após avaliação dos especialistas, o instrumento compôs-se por 36 itens e quatro domínios. Todos os itens apresentaram índice de validade de conteúdo superior a 0,78, com concordância de 0,85 a 1,00 nas avaliações. O índice de validade de conteúdo médio dos domínios e do instrumento foi maior que 0,90. Os itens dos domínios apresentaram consistência interna satisfatória. Conclusão: O instrumento de cuidado do enfermeiro apresentou conteúdo validado e confiável, sendo, portanto, seguro e de qualidade para cuidados com o paciente crítico com cateter venoso central.
TECNOLOGIAS EDUCACIONAIS PARA O DESENVOLVIMENTO DE EDUCAÇÃO NA SAÚDE: UMA REVISÃO INTEGRATIVA
Authors: Pavinati Gabriel , Lima Lucas Vinícius de , Soares João Pedro Rodrigues , Nogueira Iara Sescon , Jaques André Estevam , Baldissera Vanessa Denardi Antoniassi
Published: October 2022

A educação na saúde integra um conjunto de estratégias que possibilitam o desenvolvimento pessoal, profissional, cultural e social dos trabalhadores da saúde. Nesse sentido, o uso de tecnologias educacionais associado aos conhecimentos que os profissionais já detêm mostra-se como uma boa ferramenta para formação e consequente melhoria na qualidade do serviço prestado. Sendo assim, este trabalho buscou identificar na literatura as tecnologias educacionais utilizadas na educação na saúde. Tratou-se de uma revisão integrativa da literatura que teve como questão norteadora: quais têm sido as tecnologias educacionais utilizadas na educação na saúde identificadas na literatura? A busca eletrônica ocorreu no período de agosto a outubro de 2021, por meio das bases: SCOPUS (Elsevier); Cummulative Index to Nursing and Allied Health Literature; Web of Science; Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Base de Dados em Enfermagem e Índice Bibliográfico Español en Ciencias de la Salud via Biblioteca Virtual em Saúde; Scientific Medical Literature Analysis and Retrieval System via PUBMED e a biblioteca virtual Scientific Electronic Library Online. Foram incluídos 11 artigos primários indexados. Verificou-se uma variedade de tecnologias utilizadas como estratégias de educação na saúde, evidenciado que, em sua maioria, são do tipo leve-duras ou duras. Enfatiza-se, entre elas, as tecnologias de informação e comunicação que possuem potencial de abrangência, sendo implementadas em diversos contextos.
FACTORES DE RISCOS ERGONÓMICOS E PREVALÊNCIA DE DISTÚRBIOS MÚSCULO-ESQUELÉTICOS (DME) EM TRABALHADORES DE ESCRITÓRIOS
Authors: Chirindza Nivaldo Antonio Tomo , Duate Claudio
Published: October 2022

Introdução: Os trabalhadores que exercem actividades de escritórios usando computadores como principal instrumento, estão sujeitos ao desenvolvimento de distúrbios músculo-esqueléticos devido a posição sentada adotada prolongadas horas nesses ambientes. Objectivo: Avaliar os fatores de riscos ergonómicos e a prevalência de distúrbios músculo esqueléticos em trabalhadores dos escritórios da empresa de segurança G4S Secure Solutions Moçambique. Métodos: Participaram do estudo 58 indivíduos de ambos os sexos, com idade compreendidas entre 20 e 55 anos. Foi usado uma ficha para o registo das conformidades ergonómicas dos materiais dos escritórios bem como avaliar a postura do trabalhador por meio de observação, posteriormente estimadas as probabilidades de ocorrência e a severidade dos riscos. Os dados relativos a ocorrência dos DME foi obtida com recurso ao questionário Nordic Musculoskeletal Questionnaire. Resultados: Os principais riscos ergonómicos observados foram o posicionamento material informático em relação ao trabalhador, a postura destes durante o trabalho e por fim o estado do mobiliário. E os relacionados com ajustamento do monitor e a postura da cabeça e pescoço foram os que tiveram maior índice de severidade. A maioria relatou ter sentido desconforto músculo-esquelético em pelo menos uma região do corpo, tendo grande parte se queixado das regiões cervical, lombar, punhos/mão e região torácica. Conclusões: Com base nos resultados da presente pesquisa pode se afirmar que nos escritórios da empresa estudada existem riscos ergonómicos a ter em conta, principalmente os relacionados com a organização de material do trabalho e a postura dos trabalhadores sendo evidente pela elevada prevalência de distúrbios músculo-esquelético.
PRODUTIVIDADE DE HÍBRIDOS DE MILHO PIPOCA SUBMETIDOS A DIFERENTES POPULAÇÕES NA SEMEADURA
Authors: Sangiovo Mateus Junior Rodrigues , Basso Claudir José , Drews Álex Theodoro Noll , Primon Aline Maria , Souza Fernanda Marcolan de , Gaviraghi Lucas , Brondani Marcelo Stefanello
Published: October 2022

Quando se trata de milho pipoca o Brasil é o segundo maior produtor, mas necessitando ainda de importações para suprir a demanda interna do país, visto a importância de estudos que melhor explorem as recomendações agronômicas para a cultura do milho pipoca. [Revisor1] Assim, o presente estudo objetivou avaliar o impacto da população de plantas sobre algumas variáveis morfológicas e na produtividade final de grãos de dois híbridos de milho pipoca (8203 e 4512). Foram estudadas as populações de 60.000, 65.000, 70.000, 75.000 e 80.000 plantas por ha-1 no espaçamento de 0,45cm entre linha de semeadura. O experimento foi conduzido no ano agrícola 2018/2019, na área experimental do Departamento de Ciências Agronômicas e Ambientais da Universidade Federal de Santa Maria, campus Frederico Westphalen – RS, em um delineamento de blocos casualizados em um esquema fatorial (2x5). O diâmetro de colmo, comprimento da espiga e peso de mil sementes diminuíram à medida que se aumentou a população de plantas. Para ambos os híbridos, e para a maioria das variáveis analisadas as densidades populacionais não interferiram de forma significativa na produtividade final de grãos do milho pipoca. Entretanto quando se trabalha a média das populações se observa uma superioridade do híbrido 8203 para as variáveis, altura de planta, altura de inserção da espiga, prolificidade, empalhamento, diâmetro de espiga, número de grãos por espiga, peso de mil sementes e produtividade final de grãos.
IMPACTOS DO ESTATUTO DA CIDADE NA USUCAPIÃO COLETIVA URBANA: A EFETIVAÇÃO DA FUNÇÃO SOCIAL DA PROPRIEDADE E DA MORADIA
Authors: Augusto Ilnah Toledo , Calissi Jamile Gonçalves
Published: October 2022

A pesquisa tem por objeto a usucapião, que é um instituto do Direito Civil utilizado no Brasil, especialmente para aquisição originária da propriedade pela prescrição, que poderá ser chamada também de prescrição aquisitiva, e é regulamentada pelo direito das coisas. A pesquisa se justifica porque com a criação do Estatuto da Cidade, Lei n° 10257/01 há a previsão de uma nova modalidade de usucapião, que é a usucapião coletiva, designados para pessoas de baixa renda, com um imóvel com mais de duzentos e cinquenta metros, sem identificação, mostrando a verdadeira função social da propriedade e garantindo o direito à moradia para essa população. Adotar-se-á como metodologia científica, os métodos analítico-indutivo, a partir dos quais, mediante análise da legislação correspondente, bem como, doutrina e jurisprudência, analisar-se-á o contexto fático e social da discussão proposta.
Efficiency of crop rotations with different proportions of red clover, silage and grain forage crops in the forest-steppe of the Irkutsk region
Authors: Бояркин Е. , Солодун В. , Матаис Л. , Глушкова О.
Published: October 2022

В полевом кормопроизводстве Иркутской области производится до 80% всех кормов для отрасли животноводства. Большая часть кормовых культур сосредоточена не в специальных кормовых, а в полевых севооборотах, где кормовые культуры чаще рассматриваются только как хорошие предшественники, а сами они размещаются после зерновых или зернофуражных культур по поздним осенним обработкам. Многочисленные исследования доказали, что эффективную систему полевого кормопроизводства можно создать только на основе специализированных прифермских кормовых севооборотов, где возможен более широкий набор различных культур, их оптимальное и адаптивное соотношение и размещение. Расширение посевов бобовых многолетних трав в севооборотах решает не только проблему количества и качества кормов, но и повышает плодородие почв за счёт симбиотической фиксации азота. Проведённые исследования в трёх пятипольных кормовых севооборотах с разной насыщенностью клевером луговым, силосными и зернофуражными культурами на серых лесных почвах Иркутской области позволили установить, что в плодосменном севообороте с чередованием культур ячмень + клевер – горох + овёс + клевер (на зелёную массу) – клевер – кукуруза (на силос) с системой удобрений: N60P30K30 — под зернофуражные, N90P40K40 — под кукурузу, N60 — под однолетние травы и клевер — обеспечивает до 3,2 т/га корм. ед., нормативное содержание переваримого протеина (105–110 г) в 1 корм. ед. и высокие показатели экономической эффективности.

Field forage production of the Irkutsk region provides Animal Husbandry with up to 80% of all the fodder. Most forage crops are integrated into field crop rotations where they perform as effective preceding crops and grow after grain or grain forage plants in late autumn. Multiple investigations proved that efficient system of fodder production in field can only be maintained as by-farm crop rotations. Such rotations enable growing wide number of various crops as optimal mixtures under preferable conditions. Incorporating more perennial legume grasses into crop rotations increases quantity and quality of feed as well as improves soil fertility due to symbiotic ability of nitrogen fixation. The paper reports on three five-field crop rotations that took place on grey forest soil. Proportion of red clover, silage and grain forage crops varied among the rotations. It was revealed that rotation of barley + clover – pea + oats + clover (for green mass production) – clover – maize (for ensiling) provided up to 3.2 t feed units ha-1, standard content of digestible protein (105–110 g) in 1 feed unit and high values of economic efficacy. Grain forage crops were fertilized by N60P30K30, maize — by N90P40K40, annual grasses and clover — by N60.
Effect of primary tillage on water regime and chickpea yield
Authors: Лёвкина А. , Солодовников А. , Шагиев Б. , Беляева А. , Полетаев И.
Published: October 2022

В результате исследований установлено, что перед посевом нута наибольшая влажность почвы отмечалась при безотвальной глубокой обработке, особенно в нижних горизонтах. В период вегетации нута при выпадении весенне-летних осадков в вариантах со вспашкой влага лучше проникала в почву, улучшая водный режим посевов нута. С наступлением фазы образования бобов у нута лучший водный режим формировался при вспашке. Применение безотвальной обработки увеличивало использование влаги на 9,4%, минимальной — на 4,7%, комбинированной — на 5,3%. В условиях засушливого Саратовского Заволжья установлена высокая степень связи урожайности зерна нута с влажностью почвы в метровом слое в фазу ветвления, рост данного показателя на 1% увеличивал продуктивность нута на 0,23 т/га. Комбинированная обработка плугом ПБС-8М на тёмно-каштановых почвах Саратовского Заволжья обеспечивала повышение урожайности нута на 6,42%. Минимализация обработки почвы (БДМ 7×3 на 10–12 см) уменьшала продуктивность нута на 13,76%, безотвальное глубокое рыхление (SSD-4 на 30–32 см) — на 2,75% по сравнению с классической обработкой (ПЛН-8-35 на 23–25 см).

The highest water content in soil was observed under boardless plowing prior to chickpea seeding, particularly in lower layers. In the period of chickpea vegetation spring-summer precipitations entered soil more efficiently in plowed variants, improving water regime of the plant. At pod formation stage the best water regime happened under plowing. Boardless plowing increased water use by 9.4%, minimum tillage — by 4.7%, integrated tillage — by 5.3%. Under dry conditions of the Saratov Trans-Volga region significant correlation was established between grain yield and soil water content for meter-deep layer at chickpea branching stage. Increase in water availability by 1% raised chickpea productivity by 0.23 t ha-1. Integrated tillage by the plough PBS-8M improved chickpea productivity by 6.42% on dark chestnut soil. Minimum tillage (BDM 7×3 at 10–12 cm) reduced yield by 13.76%, subsoiling (SSD-4 at 30–32 cm) — by 2.75% compared to conventional cultivation (PLN-8-35 at 23–25 cm).
Effect of grain treatment on root rot and spring wheat productivity
Authors: Пилипенко Н. , Андреева О.
Published: October 2022

Изучено влияние протравителей (фунгицидов «Дивиденд стар», «Винцит», биопрепаратов «Биосил», «Планриз») и их смесей на развитие корневой гнили на семенах (в лабораторных условиях) и в период вегетации растений на качество семян, число продуктивных стеблей, озернённость колоса, массу зерна с одного колоса, массу 1000 зёрен, а также на урожайность яровой мягкой пшеницы Бурятская 79. Выявлено положительное влияние предпосевной обработки семян биологическими препаратами как в чистом виде, так и в смесях с фунгицидами. Установлено, что в лабораторных условиях интенсивность поражения корневыми гнилями снижалась на 10,5–17,3%, при этом повышалось количество сильных проростков на 1–8 шт., масса корней — на 0,02–0,11 г, масса ростков — на 0,08–0,15 г. В период вегетации растений пшеницы в полевых условиях интенсивность поражения корневыми гнилями от всходов к уборке возрастала: в контроле (без обработки семян протравителями) — с 72 до 82–85%, в вариантах с обработкой биопрепаратами и фунгицидами — с 59–68 до 63–76%. Разница в степени поражения между контролем и сравниваемыми вариантами в фазу кущения составила 35 и 11–20%, перед уборкой — 41 и 30–38% соответственно. Протравливание семян биопрепаратами «Биосил» и «Планриз» в чистом виде повышало урожайность пшеницы на 0,19–0,20 т/га, а их смесями с фунгицидами «Винцит», «Дивиденд стар» — на 0,41–0,51 т/га.

The experiment tested the influence of fungicides “Dividend star” and “Vintsit”, biopreparations “Biosil” and “Planriz” as well as their mixtures on root rot infection, seed quality, number of productive stems, grain number and weight per one head, 1000 kernel weight and productivity of hexaploid wheat “Buryatskaya 79” under the lab and field conditions. Seed treatment both by pure biopreparations and their mixtures with fungicides had positive effect. In lab fungal infection dropped by 10,5–17,3%, number of viable seedlings increased by 1–8 pcs, root weight — by 0.02–0.11 g, sprout weight — by 0.08–0.15 g. In field infection level grew from germination to harvesting time: in the control variant (no seed treatment) — from 72 to 82–85%, in the treated ones — from 59–68 to 63–76%. The difference in the infection level between the control and experimental variants made up 35 and 11–20% at tillering time, before harvesting — 41 and 30–38%, respectively. Seed treatment by pure biopreparations improved wheat productivity by 0.19–0.20 t ha-1 while by mixtures with fungicides — by 0.41–0.51 t ha-1.
Analysis of the toroidal coil approximation technique for the electromagnetic simulations
Authors: Архипов Дмитрий Александрович , Шурина Элла Петровна
Published: October 2022

Предложены два метода аппроксимации тороидального источника электромагнитного поля для решения системы уравнений Максвелла в естественных переменных векторным методом конечных элементов: электрическая постановка (плотность электрического тока вдоль обмотки катушки); магнитная постановка (эффективная плотность магнитного тока в сердечнике катушки). Выполнен сравнительный анализ методов в зависимости от электрофизических и геометрических характеристик источника и свойств среды. Численные эксперименты демонстрируют преимущество аппроксимации тороидальной генераторной катушки плотностью магнитного тока.

Objective. In well-logging applications, the electromagnetic field is generated by the toroidal or solenoidal coils. The physically correct and efficient approximation of these coils is of utmost importance. In this paper, we propose two techniques to approximate the toroidal coil: the electric source and the magnetic source. Methods. In the frequency domain the electromagnetic field is governed by the second-order partial differential equation for the electric or magnetic fields. The computational scheme is based on the vector finite element method with a hierarchical basis of the complete second order. The tetrahedral discretization of the computational domain is non-uniform. When approximating the toroidal coil as an electric current density in the coil winding, the finite element mesh must capture the geometry of the winding. For a coil with multiple winding turns, it results in an extremely fine mesh, which leads to large linear systems, hence, poor solver performance. To overcome this, we develop a new technique for approximating a toroidal coil as a magnetic current density in the core of the coil. This approach does not require including the winding into the finite element mesh. Therefore, the size of the resulting linear system is independent of the number of turns in the coil winding. Results. The article shows that the magnetic current density in the generator coil does not depend on the host medium, but is determined only by the geometric (core size and number of turns) and electrophysical characteristics of the toroidal source core. The paper presents the distribution of the electromagnetic field strength for both formulations in a homogeneous medium. Conclusion. The behavior of the electromagnetic field is the same for both methods of source approximation, but the magnetic formulation does not depend on the geometry of the toroidal coil therefore the computational mesh does no.
On M-polynomial and associated topological descriptors of subdivided Hex-derived network of type three
Authors: Дас Шибсанкар , Рай Шиха
Published: October 2022

Топологические индексы имеют то числовое значение, которое обычно описывает многочисленные свойства молекулярных графов, такие как физические, химические, биологические и т. д. Сегодня очень распространено вычисление различных топологических индексов на основе степеней с помощью М-полинома. Шестнадцатеричные сети широко используются в области фармацевтики, телекоммуникационных сетей и электроники. В настоящем исследовании построена подразделенная сотовая сеть третьего типа размерности и получен соответствующий M-полином. Вычислены основанные на степени топологические индексы вышеуказанной сети с использованием их прямых формул и, альтернативно, точного выражения М-полинома. Кроме того, очерчен М-полином и связанные с ним топологические индексы для различных значений . Достигнутые результаты могут стать основой для дальнейшего изучения подразделенных сотовых сетей, их свойств и устройства.

Topological indices have the numerical worth that usually describes the numerous properties of molecular graphs, such as physical, chemical, biological, etc. At the present time, it is very prevalent to calculate various degree-based topological indices by using the M-polynomial. Hex-derived networks are used extensively in the field of pharmaceutics, telecommunications networks, and electronics. In the current study, we construct the subdivided Hex-derived network of third type of dimension and obtain its corresponding M-polynomial. Further, we calculate the degree-based topological indices of the above network by using their direct formulas and alternatively from the exact expression of the M-polynomial. In addition, we sketch the M-polynomial and the related topological indices for different values of . The attained results can set a foundation to explore further into subdivided Hex-derived networks, their properties and appliances.
Simulation of distributed sequence number routing algorithm
Authors: Хаю Хуссейн , Орлова Маргарита Андреевна , Абросимов Леонид Иванович
Published: October 2022

Масштабирование является растущей проблемой в сетях, особенно в центрах обработки данных. Существует потребность в простых масштабируемых протоколах маршрутизации для упрощения автоматизации и управления постоянно растущими сетями. DSN (Протокол распределенного порядкового номера) был предложен авторами для решения проблем маршрутизации в больших сетях. DSN использует гибридный алгоритм состояния каналов и дистанционно-векторный для достижения масштабируемости и простоты. В этой работе представлено моделирование алгоритма DSN.

Scaling is a growing challenge in networks, especially in data centers. There is a need for simple scalable routing protocols to ease the automation and management of constantly growing networks. Distributed sequence number (DSN) protocol was proposed by the authors to address, the challenges of routing in large networks. DSN uses a hybrid distance vector link state algorithm to achieve scalability and simplicity. In this work, the simulation of DSN algorithm is presented.
Schedule formation in multi-project developments management systems
Authors: Пургина Марина Владимировна , Добрынин Алексей Сергеевич , Койнов Роман Сергеевич
Published: October 2022

Важный фактор повышения качества планирования - построение расписаний в проектной, производственной и экономической деятельности. Целесообразно использовать автоматизированные процедуры построения расписаний. Следует отметить, что некоторые теоретические и прикладные аспекты их формирования хорошо проработаны и описаны в литературе. Тем не менее в реальной практике деятельности человеческих коллективов очень распространен случай, когда проектные или производственные группы одновременно работают с несколькими проектами. Поэтому задача автоматизированного построения расписаний для мультипроектной деятельности является актуальной. В статье рассмотрены новые подходы и механизмы разработки программно-инструментальных средств автоматизированного составления расписаний для мультипроектной деятельности, которые были опробованы авторами при создании соответствующего программного обеспечения.

Modern mathematical apparatus, as well as achievements in the field of system analysis, game theory, graph theory, make it possible to algorithmize the process of solving the schedulling problem for various areas of human activity. To date, the areas of effective application of many wellknown, including modern heuristic and metaheuristic, algorithms that have shown good results in practice have been analyzed and identified. However, despite the achievements in the field of discrete optimization, schedulling and network planning, new tasks of drawing up the so-called coordinated schedules in the field of multi-project planning, which take into account the preferences (requests) of specific schedulling executors, are still of practical interest. Approaches and main stages of solving the problems of building coordinated schedules in multi-project planning are considered, which is relevant for the development of new generation software and tools.
SolvBERT for solvation free energy and solubility prediction: a demonstration of an NLP model for predicting the properties of molecular complexes
Authors: Yu Jiahui , Zhang Chengwei , Cheng Yingying , Yang Yun-Fang , She Yuan-Bin , Liu Fengfan , Su Weike , Su An
Published: October 2022

Deep learning models based on NLP, mainly the Transformer family, have been successfully applied to solve many chemistry-related problems, but their applications are mostly limited to chemical reactions. Meanwhile, solvation is an important concept in physical and organic chemistry, describing the interaction of solutes and solvents. This interaction leads to a solvation complex, a molecular complex similar to a reactant-reagent complex. In this study, we introduced the SolvBERT model, which reads the solute and solvents through the SMILES representation of the solvation complex. SolvBERT is pretrained in an unsupervised learning fashion using a large database of computational solvation free energies. The pretrained model can be used to predict the experimental solvation free energy or solubility, depending on the fine-tuning database. To the best of our knowledge, this multi-task prediction capability has not been observed in previously developed graph-based models for predicting the properties of molecular complexes. Furthermore, the performance of our SolvBERT in predicting solvation free energy is comparable to the state-of-the-art graph-based model DMPNN, mainly due to the clustering feature of the pretraining phase of the model, as demonstrated by the TMAP visualization algorithm.
Synthesis of pyrrothiamine, a novel thiamine analogue, and evaluation of derivatives as potent and selective inhibitors of pyruvate dehydrogenase
Authors: Chan Alex H. Y. , Ho Terence C. S. , Agyei-Owusu Kwasi , Leeper Finian James
Published: October 2022

Inhibition of thiamine pyrophosphate (TPP)-dependent enzymes with thiamine/TPP analogues that have the central thiazolium ring replaced with other rings is well established, but a limited number of central rings have been reported. We report a novel analogue, pyrrothiamine, with a central pyrrole ring. We further develop pyrrothiamine derivatives as potent and selective inhibitors of pyruvate dehydrogenase, which might have anti-cancer potential.
Enantioselective Assembly of Ferrocenes with Axial and Planar Chiralities via Palladium/Chiral Norbornene Cooperative Catalysis
Authors: Ye Jinxiang , Li Lisha , You Yiming , Jiao Chengkang , Cui Ziyang , Zhang Yabin , Jia Shihu , Cong Hengjiang , Liu Shanshan , Cheng Hong-Gang , Zhou Qianghui
Published: October 2022

The preparation of ferrocenes with both axial and planar chiralities poses a considerable challenge. Herein we report a new strategy for the construction of both axial and planar chiralities in a ferrocene system via palladium/chiral norbornene (Pd/NBE*) cooperative catalysis. In this fascinating domino reaction, the firstly established axial chirality is dictated by Pd/NBE* cooperative catalysis, while the latter planar chirality is controlled by the pre-installed axial chirality through a unique axial-to-planar diastereoinduction process. This method exploits readily available ortho-ferrocene-tethered aryl iodides (14 examples) and the bulky 2,6-disubstituted aryl bromides (14 examples) as the starting materials. 5- to 7-membered benzo-fused ferrocenes with both axial and planar chiralities (29 examples) are obtained in one step with constantly excellent enantioselectivities (> 99% e.e.) and diastereoselectivities (> 19:1 d.r.).
Complexation-Induced N‒P Axial Chirality in Sm(II) N-Phosphine-Oxide-Substituted Imidazolylidene and Imidazolinylidene Complexes
Authors: Hoshimoto Yoichi , Yamauchi Yasuhiro , Terada Tomoya , Ogoshi Sensuke
Published: October 2022

Two types of Sm(II) complexes bearing either an N-phosphine-oxide-substituted imidazolylidene (PoxIm) or the corresponding imidazolinylidene (SPoxIm) were successfully prepared and characterized using single crystal X-ray diffraction analysis. The general formula of the structures of the complexes was found to be (anti-k-O-(S)PoxIm)nSmX2(THF)m where X = I, n = 2, m = 2 or X = pentamethylcyclopentadienyl, n = 1, m = 0. The carbene carbon atoms remained intact in these complexes. In some cases, axial chirality was clearly induced around the N‒P bonds due to the restricted rotation of the N-phosphinoyl moieties, which arises from the formation of N-phosphinoyl oxygen‒Sm(II) bonds. This work highlights a rare example of complexation-induced N‒P axial chirality and new aspects regarding lanthanide complexes of multifunctional multipurpose carbenes.
REMEMBER TO NOT FORGET
Authors: Draganić Anđela
Published: October 2022

In 2019, Serbia marked the 20th anniversary of the end of the Kosovo War through numerous commemorations that received significant media coverage. Through qualitative, ideographical research, this article explores how the Serbian media constructs the collective memory of the 1999 NATO intervention. By using thematic analysis and coding, the article analyses a total of ten newspaper articles from two newspaper outlets. Three themes emerged from the analysis: 1. “Unjustified and premeditated bombing campaign”; 2. “Do not forget Milica!”; and 3. “No justice?”. The thread that unites all three themes is the element of victimhood that the media frames and positions at the centre of collective memory. The article concludes that this view of victimhood is not an anomaly in history, but is aligned with the existing collective memory through the continuous emphasis on the suffering of Serbs.
WHAT WE DO WHEN WE SAY ‘MEISJE’
Authors: Van Lookeren Campagne Judith
Published: October 2022

This paper provides a philosophical reflection on a very common word in the Dutch language. Referring to Ludwig Wittgenstein’s book Philosophical Investigations, this paper explains how the meaning of every word is based on convention. Moreover, by argu-ing that language is an act, this paper shows how using the word meisje in contemporary Dutch perpetuates the convention on which the meaning of that word has been built. From a contemporary per-spective, this convention seems sexist. Despite the fact that this paper is written from a philosophical perspective, it does make an argument that is important for other academic fields, such as cul-tural studies, gender studies, history, and in fact any discipline that makes use of language: that the language one uses is not neutral. Understanding the conventions words are built upon allows one to gain insight into the historically created dynamics which influence societal and interpersonal relations.
FEMALE HOMELESSNESS
Authors: Pampel Anna Maria , Stegmaier Mari Ann
Published: October 2022

Addressing a gap in literature about female homelessness, this paper analyzes the role of social relationships in the lives of homeless women. Bourdieu’s theory of social capital and Granovetter’s theory of social ties are used as a theoretical framework. The specific analytical focus is on social relationships with family and romantic partners and how these relationships contribute to homeless women’s social capital. It was firstly found that despite family being a source of emotional and instrumental support, homeless women’s limited or absent family relations represent a burden. Secondly, romantic relationships can provide support and simultaneously represent a straining factor. We conclude that social relationships to both family and romantic partners can in some cases be a source of support but most often are an additional burden to the already disadvantaged situation of homeless women.
Comparison of common wheat and spelt by total lipids and fatty acid levels
Authors: Relina L. , Suprun O. , Bohuslavskyi R. , Vecherska L. , Leonov O. , Antsyferova O. , Golik O.
Published: October 2022

Nowadays the interest of breeders, producers and consumers is going back to ancient wheat species, such as Triticum spelta, which are often considered as more valuable for healthy nutrition. In this light, we compared spelt cultivars and breeding lines with commercial common wheat cultivars by total lipid content, fatty acid levels and unsaturated/saturated ratio in grain. Lipids were extracted by Soxhlet procedure. Fatty acid composition was determined by gas chromatography. On average, the total lipid content was higher in the spelt cultivars than in the breeding spelt lines (3.04±0.24 % vs. 2.23±0.69 %, p < 0.05). There was a significant difference between the average content of total lipids in the spelt cultivars, but not the breeding spelt lines, and the common wheat cultivars (3.04±0.24 % vs. 2.44±0.57 %, p < 0.05). Six major fatty acids were found in hexaploid wheat species, with linoleic acid being the most abundant. They are ranked in order of decreasing levels as follows: linoleic > oleic >palmitic > linolenic > stearic > palmitoleic. We also detected trace amounts of 3 minor fatty acids: eicosanoic (arachidic), eicosenoic and behenic acids. Common wheat is not inferior to spelt in terms of unsaturated fatty acid levels, because the ratios of unsaturated acids to saturated ones in grain of T. spelta accessions were similar to those in commercial common wheat cultivars. The oleic acid content was higher in spelt accessions; though the linoleic acid content was higher in T. aestivum cultivars. Spring common wheat cultivar Heroinia had the most beneficial unsaturated/saturated ratio of 4.5. We detected no differences in unsaturated acid amounts between spring and winter hexaploid wheats. We observed no patterns in variability of fatty acid contents across the accessions under investigation, because the same accession can be characterized by a wide variability in one fatty acid and by a narrow range for another, and, at the same time, the same fatty acid can be very variable within one accession and little variable in another. There were no significant differences in the total lipid content and fatty acid levels between the study years for the same accession.
Modulating effect of liposomal miR-101 on the processes of amyloidogenesis, smell, sleep and neuroinflammation in experimental Alzheimer's disease
Authors: Sokolik V. , Levicheva N. , Geiko V. , Berchenko O. , Shulga S.
Published: October 2022

The current therapy for Alzheimer's disease does not give patients a chance of recovery. Therefore, it is relevant to study the novel factors of influence, in particular microRNA, on the pathogenic mechanisms of amyloidosis. The aim of this work was to determine the effect of miR-101 on early predictors of amyloidosis in experimental Alzheimer's disease in animals. The study was carried out on 25 male rats of 14 months of age. A model of Alzheimer's disease was created by intrahippocampal administration of Aβ40 aggregates to animals. Ten days later, a 10-day course of nasal administration of miR-101 in liposomes was launched. The level of endogenous Aβ42 and cytokines (TNFα, IL-6 and IL-10) was determined in the supernatants of the nerve tissues of the target brain structures (hippocampus, olfactory bulbs, and olfactory tubercles). A neuroethological method of presenting smells of isovaleric acid and peanut butter was used to assess the olfactory system functional state in the experimental rats. In the course of polygraphic registration of the sleep-wakefulness cycle, the representation of wakefulness and individual sleep phases, as well as proportion of incomplete and complete sleep cycles were determined. It was shown that injection of Aβ40 aggregates into the hippocampus simulates an amyloidogenic state in the rat’s hippocampus and olfactory tubercles, but not in the olfactory bulbs. Moreover, a pro-inflammatory state was registered in the hippocampus of the animal brain (an increase in the concentration of pro-inflammatory cytokines TNFα and IL-6), while the cytokine level in the olfactory bulbs and tubercles did not change. When studying the functional state of olfactory analyzers in the rats with Alzheimer's disease, we revealed negative changes in behavioral response to the smell of isovaleric acid and peanut butter. In terms of somnograms, the Aβ40 toxicity caused reduction in the deep slow-wave sleep stage combined with deficiency of the paradoxical sleep phase, and predominance of incomplete sleep cycles. Nasal therapy with miR-101 in liposomes normalized the level of Aβ42 in the hippocampus and olfactory tubercles and decreased the level of proinflammatory cytokines in the hippocampus. MiR-101 prevented olfactory disfunctions in assessing smells of isovaleric acid and peanut butter, increased the ratio of deep slow-wave sleep and paradoxical sleep in the cycle structure and restored proportion of complete sleep cycles in animals. Thus, liposomal miR-101 has an anti-amyloidogenic and anti-inflammatory effect in rats with a model of Alzheimer's disease. It helps to restore the functional state of olfactory analyzer and optimize structural organization of the sleep-wakefulness cycle in sick animals.
Pharmaco–cold cardioplegia during isolated prosthesis of the aortal valve
Authors: Popov V. V. , Gurtovenko O. M. , Bolshak A. A. , Boukarim V. Zh.
Published: October 2022

Objective. To study the possibilities of pharmaco–cold cardioplegia, while doing isolated prosthesis of the aortal valve.

Materials and methods. Into the investigation were included 279 patients with aortal failures, operated in Department of Surgical Treatment of the Acquired Failures of the Heart of National Institute of Cardio–Vascular Surgery named after М. М. Аmosov in 2015–2021 yrs. The average age of the patients have constituted (62,5 ± 6,4) yrs old. In all the patients the isolated аоrtal valve correction for aortal failures was performed, using mechanical and biological prostheses. Infusion of “Kustodiol” solution for defense of the myocardium was applied.

Results. On the hospital stage 9 patients died (hospital lethality have constituted 3,2%). Іnotropic support (dobutamin) in early postoperative period was applied in  dosage of 3 – 4 mcg/kg/min during first 48 h. The levels of cardiac creatine phosphokinase enzyme on the second postoperative day, while exploiting antegrade, аnteretrograde, retroantegrade and retrograde methods of the cardioplegic solution delivery, have hade differences.

Conclusion. Retrograde pathway of injection of cardioplegic solution permits to defense the myocardium effectively while correcting of aortal failure.
Supplement tо clinic-practical recommendations “Chronic diseases of veins of the lower extremities and pelvis”
Authors: Board Editorial
Published: October 2022

Supplement tо clinic-practical recommendations “Chronic diseases of veins of the lower extremities and pelvis”
LA PIRATERÍA MARÍTIMA Y SU IMPACTO AL TRANSPORTE MARÍTIMO ¿UNA AMENAZA O UN RIESGO PARA CHILE?
Authors: RIVAS PARDO PABLO , AYALA PULGAR NICOLE
Published: October 2022

La piratería marítima no ha sido una amenaza para Chile, ya que entre 1991 y 2019 no ha registrado actos en su territorio y solamente ocho buques de nacionalidad chilena han sufrido sus ataques. Sin embargo, la piratería marítima es un riesgo para Chile, ya que podría afectar directamente su transporte marítimo. Este artículo expone los princi- pales registros de la piratería marítima y analiza las características de la economía de Chile, proyectando el riesgo que implica esta amenaza para el transporte marítimo. Los resultados detallan como objeto re- ferentes las exportaciones e importaciones en relación al PIB; el trans- porte marítimo; los principales destinos y los principales orígenes con sus respectivos bienes; y los puertos de mayor valor económico.
EL DERECHO OPERACIONAL EN LAS AMENAZAS HÍBRIDAS DE LOS LIBROS BLANCOS DE PERÚ Y BRASIL
Authors: Quintero Cordero Sara , González Martínez Miguel
Published: October 2022

Perú y Brasil constituyeron sus Libros Blancos como elementos estratégicos para su política de seguridad y defensa. Compararlos es un ejercicio que va más allá de encontrar similitudes y diferencias, y en este sentido, este artículo procura reconocer cómo cada Libro Blanco es el resultado en retrospectiva de los otrora regímenes dictatoriales, buscando una nueva forma de consolidar tanto la democracia liberal, el sistema capitalista y las relaciones entre civiles y militares. El estudio establece que cada proceso responde a la necesidad propia de construir un punto de estabilización de órdenes políticos que pretenden insertarse en la complejidad que ofrece el sistema internacional con- temporáneo globalizado e interdependiente. Por ello para estos países la democracia y el respeto de los Derechos Humanos se erigen como la guía y los instrumentos internacionales es el sustrato orientador de la acción del Estado en cualquiera de sus instancias.
SERVICIO MILITAR EN CHILE: EN PERSPECTIVA HISTÓRICA Y SOCIAL
Authors: Duhalde Valenzuela Byron , Norambuena Carrasco Carmen
Published: October 2022

Este escrito presenta un abordaje histórico del sistema de conscripción militar y su papel en la inserción social en la actualidad. Su origen se encuentra en la Ley No 1.462 de 5 de septiembre de 1900, denominada Ley de Reclutas y Reemplazos del Ejército, la cual formalizó el ingreso al ejército, instaurando el Servicio Militar Obligatorio para toda la sociedad. Esta normativa, además, que dejó de lado los cánones legales que regulaban la conscripción en el Servicio de la Guardia Nacional, tuvo influencia de la llamada prusianización del ejército, y en el futuro ha desempeñado un papel decisivo en la formación de conscriptos. Junto a las reformas de la década del 2000 en la que destaca la incorporación de las mujeres, realización de capacitaciones vía SENCE, entre otros. Se demuestra cómo esta instancia que tiene como propósito constitucional capacitar a ciudadanos para participar activamente de la Defensa Nacional se configura como un espacio de promoción social.
Experiences of mediation in a Science Center: implications for the initial training of physics teachers
Authors: Galvão Cintia Torres Lemes , Rezende Junior Mikael Frank
Published: October 2022

This work investigated the implications that mediation in a Science Center can promote in initial education of future physics teachers. The qualitative research was carried out with undergraduate who act as mediators in a Science Center integrated with the formative activities of a Federal University in the State of Minas Gerais, and semi-structured interviews were used as a data collection instrument. The interviews were analyzed qualitatively, and it was possible to notice that the performance in the non-formal teaching space has direct implications in the performance of the undergraduates in the classroom, either during the internship period or during their training, in addition to contributing to a broader understanding of teaching and learning processes.