bluuebunny/crossref_metadata_2025 huggingface dataset:
Intelligent Assistance Method for Preschool Education Dance Curriculum Based on Deep Learning
Authors: Wang Qin
Published: July 2024

Preschool education is vital for shaping the foundation of young children’s development across cognitive, social, emotional, and physical dimensions. Dance courses are often included in preschool curricula to foster creativity, expression, physical coordination, and emotional regulation. Understanding and interpreting emotions conveyed through dance movements can be instrumental in enhancing children’s emotional intelligence and overall well-being. This paper investigates an innovative approach to intelligent assistance in preschool dance courses by utilizing deep learning methods for emotion recognition within dance movements. The proposed model integrates deep and shallow features to improve the precision of emotion detection, offering a promising means to facilitate personalized and interactive learning experiences. First, emotions in dance are extracted through a multi-layer convolutional neural network, and high-level features are fused with low-level features. Then, the fused features of different depths are used as the basis for emotion recognition. The convolutional neural network’s fully connected layer outputs the emotional probabilities of dance movements, allowing for the identification of emotional categories in dance movements. Finally, experiments are conducted using the fusion of features from different convolutional layers, validating the effectiveness of the proposed method in emotion recognition.
Baltic Architectural Education in Times of Crisis: Faculty of Architecture at the Baltic University in Germany, 1946–1949
Authors: Drėmaitė Marija
Published: July 2024

The article is based on the original manuscript materials and documents of the Faculty of Architecture and Engineering of the exile Baltic University (Baltische Universität), which operated in Hamburg and Pinneberg from 1946 to 1949. The Faculty of Architecture of the Baltic University was a unique establishment in exile where Estonian, Latvian and Lithuanian refugees came together to maintain their architectural education. The documents (four boxes and one roll of papers) were discovered at the Manuscript Collection of the Uppsala University Library marked as “Lettiska Fonden” and were unknown to architectural historians up to this date. This common Baltic tangible and intangible architectural heritage is a unique source for discovering and understanding the destiny of Baltic architects in exile in times of geopolitical crisis.
Community Functions of Schools and Municipal Support of Schools on the Continuum of the Rural Periphery – Town
Authors: Kubeš Jan
Published: July 2024

The article compares the community functions of schools and the support to schools from the municipality representatives and community depending on the location of the school – in peripheral or semi-peripheral rural areas, rural small towns, outer suburbs and also in towns, i.e., at various distances from the town. It is based on controlled interviews with school headmasters and mayors of the respective municipalities and on the collection of information from annual school reports and school inspection reports. A total of 57 schools of two districts in the south-west of Czechia were evaluated. The assumption that complete rural schools in peripheries have the greatest community functions was confirmed; but complete rural schools in semi-peripheries also received similar assessment. However, a fully functioning rural "community school" was not found in the case study area. Schools in towns show weak community functions, because community functions in towns are provided by other institutions and facilities.
Destination Brandscapes. Integration of Landscape Elements into Destination Brands
Authors: Sandriester Jasmin , Pizzera Judith
Published: July 2024

Encapsulating the destination’s USPs and identity in a logo with high recognition value is a challenge DMOs face. This recognisability as key to a ‘strong brand’ is particularly based on natural resources and the attractiveness of landscapes that form the basis of touristic USP in most destinations. The paper stresses the importance of the logo and that the destination’s ‘DNA’ or identity must be transposed symbolically and naturally by integrating distinctive landscape elements into the logo. Ideally, they merge authentically and harmoniously, fostering identification among locals and tourists, brand awareness and a positive image, contributing to a strong, authentic brand. A 40% presence of landscape elements (mountains prevailed by 85%) was found in the top 50 Austrian logos.
Insights on Universal Pension Scheme in Bangladesh: Trajectory or Deviation
Authors: Faeique Azmaine , Shaulin Nahida , Naoar Siena Jannateen , Ahmed Roza Meherin , Tahmeed Abdullah Mohammad
Published: July 2024

The Universal Pension Scheme (UPS) is a fairly new policy by the Bangladesh government, inaugurated on 17th August 2023, aiming at giving the nation's aging population a monthly stipend and placing them under a well-organized social safety net program. This study aimed to find out the perception of the people regarding the UPS and the challenges that beset with this perception. The study uses a quantitative method to collect data from 404 participants through a close ended questionnaire following simple random sampling. The SPSS software was used to analyze the data for chi-square testing, cross tabulation, and descriptive statistics. By conducting the Chi-square test (p0.05), the overall results of the study revealed that the general people are not much willing to participate in the Universal Pension Scheme despite knowing about it. Though many still do not properly understand the different schemes of the UPS and prefer the traditional and familiar banking procedure for saving money, many mainly refrain from agreeing to participate on it because of the risk of inflation and regime change. Thus, most people prefer investing in a business to make profit and be free from these risks that are associated with UPS.
Optimizing main cutting force in high-pressure jet-assisted turning using Taguchi method
Authors: Kramar Davorin ,   University of Ljubljana, Faculty of Mechanical Engineering, Ljubljana, Slovenia, Sekulić Milenko , Rodić Dragan , Pejić Vlastimir ,   University of Novi Sad, Faculty of Technical Sciences, Department for Production Engineering, Novi Sad, Serbia,   University of Novi Sad, Faculty of Technical Sciences, Department for Production Engineering, Novi Sad, Serbia,   Faculty of Applied Sciences in Niš, Niš, Serbia
Published: July 2024

In high pressure turning, the optimization of cutting forces is crucial to improve the efficiency and precision of machining. In this study, the Taguchi method is used to systematically investigate and optimize the input parameters that influence the cutting forces. By using an orthogonal array and analyzing the signal-to-noise ratio, the main factors affecting the cutting force are identified and their optimal values are determined. The effectiveness of the optimization is confirmed by validation tests, which show a significant improvement in cutting performance. The results provide actionable insights for machining and lead to better decision-making and process control in high-pressure turning. This research not only highlights the benefits of the Taguchi method in process optimization, but also contributes to advancing machining techniques by minimizing cutting forces and improving overall process stability.
THE EFFECTIVENESS OF HEALTH EDUCATION TRAINING WITH THE PHANTOM MEDIA DEMONSTRATION METHOD ON KNOWLEDGE AND AWARENESS SKILLS IN SMA NEGERI 3 SAMARINDA
Authors: Pramesti Gading Niken , Hazanah Sri
Published: July 2024

In Indonesia, when it comes to female cancers, breast cancer is by far the most lethal. Treatment was delayed because of a lack of education about breast cancer and how to perform a breast self-examination (BSE) for early diagnosis. Real-world targets can learn from and mimic the behaviour displayed in examples through the demonstration technique.
Objectives: This study aimed to evaluate the impact of health training using demonstrative techniques and dummy media on female students' knowledge and ability to deal with BSE.
Research Metodes: This investigation was quantitative in nature, and a one-group pretest-posttest design was adopted. There were potentially as many as 198 kids at SMA Negeri 3 Samarinda, hence a sample size of 66 was used. Simple random sampling was used. A knowledge and skills questionnaire with a value of 0.05 served as the instrument for this study.
Results: A significant effect of health education on female students' knowledge and skills on BSE was found, as indicated by a wilcoxon test p value of 0.05.
Conclusion: Health education on BSE delivered using the phantom media demonstration approach has an impact on elevating SMA Negeri 3 students' understanding of the topic. It is anticipated that it can serve as a source of inspiration and education for high school girls.
Keywords: Demonstration, SADARI, Knowledge, Skills, Teenager.
The Effect of The Covid-19 Pandemic on Recruitment of Health Workers in Private Hospitals: A Literature Review
Authors: Nafiatun Nisa
Published: July 2024

Background: The number of hospitals is increasing every year, dominated by private hospitals, so effective HRM is needed for organizational performance. HRM practices require a long process, especially in the recruitment process which consists of a series of activities to identify desired applicants. However, the emergence of Covid-19 was not predicted and requires adaptation.
Objectives: this article aims to determine the effect of Covid-19 on the recruitment of health workers in private hospitals.  
Research Metodes: literature review of 7 articles searched via ScienceDirect and Google Scholar
Results: From 7 articles, it shows that the Covid-19 pandemic has affected recruitment, namely that recruitment is only a formality and makes health workers in hospitals large in quantity, but varied in quality.
Conclusion: The Covid-19 pandemic has an impact on recruitment so that recruitment is carried out by utilizing Artificial Intelligence (AI) technology, using video conference platforms, replacing written tests with project or online presentations, adjusting schedules flexibly, and maintaining communication.
Keywords: Covid-19 Pandemic; Human Resources; Private Hospitals; Recruitment
Systematic Review of Lean Management: Hospital Transformation for Increasing Operational Efficiency and Patient Care
Authors: Putri Ayu Nurhaliza  , Muhammad Pandu Aditya  , Adinda Intan Pratiwi  , Monica Aprilla Andestri  , Elvara Angelita  , Asmaripa Ainy
Published: July 2024

Background: One of places that providing health services is a hospital which provides comprehensive health services. Therefore, one of the benchmarks that hospitals facing is to always maintain consumer trust by improving quality of services so that consumers’ satisfaction significantly increases. In this research, Lean Management has become a more popular approach in various industries including the health sector such as hospitals.
Objectives: To learn about lean management in hospitals such as how to implement lean management and find out the efficiency of lean management in hospitals.
Research Method: A systematic review that used a qualitative meta-synthesis approach based on the results of similar studies.
Results: The impacts of lean management on the quality of hospital’s health services were found.
Conclusion: The context of transformation for the hospital. Implementing lean management has a significant impact on various aspects, from operational efficiency to service quality. Applying its management allows hospitals to proactively identify areas where improvement is needed, thereby ensuring that high standards of services are maintained.
The Efforts Of Toddler Integrated Healthcare Center Cadres In Increasing Mother Visits To Integrated Healthcare Center Kartini Bandungrejosari Malang City
Authors: Lala Handy , Rania Regita Lafemme , Djuwadi Ganif
Published: July 2024

Background: One of the factors causing stunting is that the utilization rate of healthcare by mothers of toddlers in Indonesia is low, while in healthcare there is a lot of education about maintaining the health of toddlers and providing additional food for toddlers. This is proven by the average percentage of toddlers who are weighed at the healthcare is still below the target, where the target for toddlers who are weighed is 85%. There are still many healthcare that do not meet coverage shows that the role of toddler healthcare cadres in increasing mother’s visit to the healthcare less than optimal or not in accordance with their duties.
Objectives: The purpose of this study was to determine the efforts of healthcare toddler cadres in increasing maternal visits to the healthcare.
Research Metodes: This study used qualitative methods and took 13 responden, consisting of 7 healthcare cadres, 5 mothers who have toddlers, and 1 health worker. Data collection techniques using interviews, observation, documentation. Data validity used is data triangulation and method triangulation.
Results: The results show that the implementation of healthcare service activities is still not optimal, this is evidenced by the non-implementation of one of the healthcare service activities.
Conclusion: the efforts of cadres in increasing the visit of mothers of toddlers to Healthcare Kartini in Bandungrejosari Village, Sukun Subdistrict still not implemented optimally.
Comparison Of The Effectiveness Of Oxytocin Massage And Marmet Technique In Increasing Breast Milk Production In Postpartum Mothers: A Quasi-Experimental Study
Authors: Norlaila Sofia
Published: July 2024

Research Metodes: The research employ a quasi-experimental design with a pre-test and post-test approach. The sample consist of 60 pospartum mothers divided two group: the oxytocin massage group (n=30) and the marmet technique group (n=30). The intervention was conducted over 14 days, and breast milk production was measured using indicators of infant weight gain and urination frequency
Results: It showed that both techniques are effective in increasing breast milk production; however, oxytocin massage demonstrates a more significant improvement (p<0.05). In conclusion, oxytocin massage can be recommended as a primary intervention to enhance breast milk production in postpartum mothers.
Giant Left Atrial Aneurysm In A Three Year Old
Authors: Almazrouei Maitha , AbdelMassih Antoine , Shah Nishant
Published: July 2024

Background:
The PA to the LA fistula is a rare cause of central cyanosis. Embryologically, incomplete degeneration of septum between the arterial and venous plexus of the pulmonary vascular bed or defective capillary loop leads to formation of thin-walled sacs resulting in formation of pulmonary arteriovenous fistula. The more restrictive the fistula is, the more subtle is the extent of cyanosis and the less evident is the clinical presentation.
Case Description
We describe the case of three years-old patient, who presented with unresolving pneumonia, that necessitated CT imaging. CT imaging revealed a mass in the posterior mediastinum that was communicating with the left atrium. Originally it was thought that this is an aneurysmal dilation of one of the pulmonary veins, that could have resulted from mitral regurge. Echocardiography showed an aneurysmal dilation of the left atrium, with an abnormal retrograde flow across the roof of the left atrium, pulmonary hypertension and mitral regurge were excluded. 3D CT angiographic reconstruction revealed the presence of a fistulous communication between the RPA and left atrium, this explains the low normal oxygen saturations of this patient due to mixing (90-92%) and the high hemoglobin concentration (160) due to chronic subclinical hypoxia.
Conclusion and learning points
Aneurysmal dilation of left atrium is commonly encountered with severe mitral regurge, rare causes such as PA to LA fistulae should be thought of especially if clinical or subclinical hypoxia or polycythemia is present.
A surprise during hernia surgery: inguinoscrotal megaureter
Authors: Gerçel Gonca
Published: July 2024

Background. Ureteroinguinal herniation is a rare occurrence that is typically diagnosed during the surgical repair of inguinal hernias.
Case Presentation. We present the case of a 4-year-old male who underwent inguinal hernia repair, during which a megaureter was discovered within the hernia sac. The surgical intervention included high ligation of the hernial sac and repositioning of the ureter back into the retroperitoneum. Postoperative investigations confirmed a diagnosis of primary non-refluxing and nonobstructive megaureter.
Conclusion. Although ureteral herniation is rare in infants, it is crucial to remain vigilant about the possibility of encountering the ureter during hernia repair to prevent potential ureteral injuries. Additionally, any associated urinary tract anomalies should be thoroughly investigated and ruled out.
Investigation of Expected Inflation According to Adaptive Expectations Hypothesis Using Koyck Transformation: A Study on Türkiye
Authors: Alpağut Serhat
Published: July 2024

Inflation expectations have been researched theoretically and practically for more than a century and continue to be a favorite research topic for economists even today. The validity of the Rational Expectations Hypothesis has not yet been proven by empirical research, and many studies show that it is invalid. This situation drew attention again to the validity of the Adaptive Expectations Hypothesis. In this study, inflation expectations for Türkiye in the 2013m6-2023m7 period, under the assumption of the Adaptive Expectations Hypothesis, were tested first by applying the Nerlove (1958) model and secondly by applying the Koyck transformation within the framework of the Friedman-Cagan model. As a result of the study, although evidence was found that the Adaptive Expectations Hypothesis is valid in Türkiye according to the Nerlove (1958) model, it was observed that there was a weak relationship between actual inflation and expected inflation. The second model was applied to avoid hesitation in accepting the hypothesis. With the Koyck transform model, it has been determined that individuals in Türkiye learn from past inflation values in forming inflation expectations. The speed of this learning is 77%. It was concluded that individuals form their inflation expectations by using 77% of current and past inflation data. The intended history includes the current period, the first and second lags. In terms of expectations, the effect of the third lag is zero.
Pasifik Puma Ülkelerinde Demokrasinin Çevresel Bozulma Üzerindeki Etkisi: Gelir Düzeyinin Rolü
Authors: Ursavaş Neslihan
Published: July 2024

Bu çalışmanın amacı Pasifik Puma ülkelerinde (Şili, Kolombiya, Meksika ve Peru) demokrasinin çevresel bozulma üzerindeki etkisini gelirin moderatörlüğünde test etmektir. Bu amaçla 1990-2018 dönemine ait veriler kullanılarak Westerlund (2007) eş bütünleşme analizi ve Ortak İlişkili Etkiler Tahmincisi (CCE) uygulanmıştır. Demokrasi ve çevresel bozulma arasındaki ilişkiyi açıklayan yaklaşımlar göz önünde bulundurulduğunda demokrasinin çevre üzerindeki etkisi farklılaşmaktadır. Bu farklılaşmanın önemli bir nedeni demokrasi- çevre ilişkisini açıklamada gelirin düzenleyici rolünün göz ardı edilmesi olabilir. Bu bağlamda çalışmada çarpımsal etkileşim modeli kullanılarak gelir ve demokrasi düzeyindeki değişikliklerin çevresel bozulmayı nasıl etkilediği incelenmiştir. Çalışmada çevresel bozulma göstergesi olarak ekolojik ayak izi (EF) endeksi kullanılmıştır. Elde edilen bulgulara göre uzun dönemde değişkenler arasında eş bütünleşme ilişkisi bulunmaktadır. Çalışmanın diğer bulgularına göre demokrasi ve gelir düzeyindeki artış ekolojik ayak izini artırmaktadır. Bununla birlikte demokrasinin ekolojik ayak izi zerindeki etkisinde gelirin rolü önemli olmaktadır. Gelir düzeyi arttıkça demokrasideki artış ekolojik ayak izini azaltmaktadır. Dolayısıyla demokrasinin ekolojik ayak izi üzerindeki etkisi gelir düzeyi ile koşullandırılmaktadır.
1990-2022 Dönemi Türkiye'de Gelir Üzerinden Alınan Vergiler ve Ekonomik Büyüme İlişkisi
Authors: Ünsal Yusuf
Published: July 2024

Bu çalışma, 1990-2022 döneminde Türkiye'de ekonomik büyüme ve gelir üzerinden alınan vergiler arasındaki ilişkiyi incelemektedir. Ekonomik büyüme, tarih boyunca toplumlar için merkezi bir olgu olmuştur ve ulusların refahı üzerindeki etkisi hem gelişmekte olan hem de gelişmiş ülkeler için temel bir endişe kaynağıdır. Maliye politikaları, özellikle de vergilendirme, hedeflenen ekonomik büyüme seviyelerine ulaşılmasında önemli bir rol oynamaktadır. Bu araştırma, ekonomik büyüme ve gelir üzerinden alınan vergiler arasındaki uzun vadeli dinamikleri araştırmak için zaman serisi veri analizi yöntemlerinden biri olan Otoregresif Dağıtılmış Gecikme (ARDL) sınır testini kullanmaktadır. Bulgular, uzun vadede gelir üzerinden alınan vergilerinden ekonomik büyümeye doğru bir ilişki olmadığını göstermektedir. Ancak, ekonomik büyümeden gelir üzerinden alınan vergilere doğru anlamlı pozitif bir ilişki gözlenmiştir. Bu çalışma, söz konusu ilişkinin Türkiye bağlamında bir analizini sunarak mevcut literatüre katkıda bulunmakta ve ekonomik büyümenin gelir üzerinden alınan vergi gelirleri üzerindeki olumlu etkisinin maliye politikası planlamasında kritik bir araç olabileceğini öne sürmektedir.
Grossman’s Generalised Health Demand Model: An Application on Türkiye
Authors: Kara Oğuz
Published: July 2024

Health is the main source of economic activity and human capital. Each individual wants to be healthy throughout her life in order to maximize his/her individual benefit and strives for this. In this study, which examined the health demand of individuals, Grossman's health demand (consumption and investment) model, which pioneered research on health demand, was referenced. The demands of 25825 individuals for medical care included in the 2016 and 2019 health research micro datasets in Türkiye were examined using the negative binomial regression model. In addition, the effects of human capital components (education, income, etc.) on the general health status of individuals were analyzed using the ordinal logit model. Health demand is influenced by economic variables as well as social and cultural factors and individuals' life behaviors. Such variables are also included in the analysis. According to the results, it was seen that individuals with chronic diseases are more likely to receive medical care than those who do not have such a disease. Besides, it was concluded that education, income, and sports exercises improve the health status of individuals, whereas aging and an increase in the number of diseases worsen the health status.
Expanding the intellectual capabilities of OLAP technology using neural networks
Authors: Nabibayova Gulnara ,   Institute of Information Technology, Baku, Azerbaijan
Published: July 2024

The article highlights the main characteristics, features and structure of Online Analytical Processing systems based on the same technology that perform online analytical processing of data. This technology allows analysts to explore and navigate a multidimensional indicator structure called an online analytical processing cube (data cube). Indicators (measures) of data cube play an important role in the decision-making process. To solve certain problems, these measures often need to be classified or grouped. Moreover, empty measures are common in data cube. This fact negatively affects strategic decision making. Unfortunately, online analytical processing itself is not well suited for classifying, clustering, and predicting empty measures of data cube in the presence of large data. In this regard, today there is a need to use new technologies to solve such problems. Such technologies include neural networks. The article discusses the problem of integrating online analytical processing and a neural network, showing the possibilities and advantages of such integration. It mentions that in the case of big data, the integration of OLAP and neural networks is very effective in solving problems of classification, clustering and empty measure prediction of data cube. An architectural and technological model for the integration of online analytical processing and neural networks is presented.
Implementation of artificial intelligence by using Amazon web services to improve services in e-government
Authors: Al Qudah Mohammad Ali ,   Department of Computer Science, Khazar University, Baku, Azerbaijan, Muradkhanli Leyla , Abuhashish Mutaz Mohammed ,   Department of Information Technology, Baku Higher Oil School, Baku, Azerbaijan,   Institute of Control Systems, Baku, Azerbaijan,   Department of Computer Science, Khazar University, Baku, Azerbaijan,   Department of Computer Science, Khazar University, Baku, Azerbaijan,   College of Engineering and Information Technology, Al Azhar University, Palestine, Gaza
Published: July 2024

The implementation of artificial intelligence has the scope to revolutionize e-government services by enhancing the quality of life for citizens, enhancing operational efficiency, and enabling groundbreaking applications. There is a possibility that this can be achieved through technical improvements. A wide range of artificial intelligence technologies and services are offered by Amazon Web Services, which has the potential to alter how e-government services are provided. The purpose of this abstract is to study the revolutionary potential of artificial intelligence by utilizing Amazon Web Services and to highlight the benefits and possibilities that it provides to the field of e-government. The utilization of artificial intelligence in conjunction with Amazon Web Services has the potential to significantly enhance the quality of e-government services by reducing inefficiencies, enabling the development of creative applications, and enabling the customization of experiences. With the assistance of the artificial intelligence tools and services offered by Amazon Web Services, the public sector can take advantage of the revolutionary power of artificial intelligence while also ensuring that responsible and ethical practices are followed.
Exploring teachers' artificial intelligence awareness
Authors: Uygun Derya , Aktaş Işıl , Duygulu İsmail , Köseer Numan
Published: July 2024

The impact of artificial intelligence (AI) technological advancements is reshaping various aspects of our daily lives, including education. Integrating AI in education offers advantages such as personalized learning and operational efficiency. However, educators need to be aware of AI's implications in education. Teachers must enhance their awareness and knowledge levels to adapt to the educational environment where AI technologies are becoming increasingly prevalent. Therefore, this research aims to assess teachers' AI awareness levels and investigate whether AI awareness varies based on age, graduation status, and years of experience. This study used data collected from 147 educators using the Teachers' Artificial Intelligence Awareness Scale. The results indicated that teachers' AI awareness was at a moderate level. Additionally, the study examined teachers' AI awareness across different variables. Independent sample t-tests and one-way ANOVA analyses determined teachers' AI awareness variation based on age. The research findings suggest that younger educators and those with higher academic qualifications have more excellent practical knowledge of AI. The study's limitations included a relatively small sample size and the assumption of accurate participant responses. Despite these limitations, understanding teachers' AI awareness levels is a foundation for developing educational programs related to AI. By understanding teachers' perceptions and knowledge of AI, tailored interventions and training initiatives can enhance educators' proficiency in effectively utilizing AI technologies within educational settings.
Diretrizes da Associação Brasileira de Psiquiatria para o manejo do comportamento suicida: intervenção
Authors: Baldaçara Leonardo , Périco Cintia de Azevedo-Marques , Pinto Flavia Ismael , Grudtner Roberta Rossi , Calfat Elie Leal de Barros , Rocha Gislene Alves da , Porto Deisy Mendes , Leite Verônica da Silveira , Robis Kelly Pereira , Fidalgo Thiago Marques , Diaz Alexandre Paim , Meleiro Alexandrina Maria Augusto da Silva , Malloy-Diniz Leandro Fernandes , Silva Filho Humberto Corrêa da , Quevedo João , Tung Teng Chei , Da Silva Antônio Geraldo
Published: July 2024

A complexidade dos comportamentos suicidas requer uma abordagem multifacetada para sua gestão, envolvendo a avaliação de fatores de risco e proteção, bem como intervenções apropriadas. A Associação Brasileira de Psiquiatria (ABP), por meio da sua Comissão de Emergências Psiquiátricas, elaborou diretrizes específicas para o manejo de pacientes com comportamento suicida, com foco em triagem, intervenção, prevenção e promoção da saúde mental. Embora a evidência disponível ainda apresente controvérsias e limitações, já é possível identificar a eficácia de certas intervenções para grupos específicos de pacientes. A recomendação atual inclui a combinação de várias técnicas, como o Plano de Segurança, que integra a avaliação de fatores de risco e proteção com medidas terapêuticas subsequentes. Destaca-se a necessidade de pesquisas adicionais para esclarecer abordagens com potencial específico para intervenção, visando sempre otimizar as estratégias de manejo do comportamento suicida e incorporá-las nas políticas públicas de saúde.
Still Far From Home – How Personal Jurisdiction Doctrine Undercuts The Montreal Convention’s “Fifth Jurisdiction” For “Wandering Americans”
Authors: Huggler Hans
Published: July 2024

The rapid growth of global air travel in the mid-20th century gave rise to the problem of the “wandering American”—American residents whose air travel injury claims could not be heard in United States courts under the Warsaw Convention’s Article 28. Prominent cases prompted adoption of a “fifth jurisdiction” in the Montreal Convention’s Article 33, allowing injury suits in the Contracting State where an injured passenger had her “principal and permanent residence” so long as the international carrier served the forum. U.S. officials toasted their success in providing Americans with a domestic forum, but the adoption of the fifth jurisdiction did not finish the job. Even if an American plaintiff meets Article 33’s requirements, personal jurisdiction problems can bar the courthouse door. This article re-examines the problem of the “wandering American” and the fierce debates over the fifth jurisdiction at the 1999 International Conference on Air Law in Montreal through the lens of personal jurisdiction. It argues that the Montreal Convention would likely not have changed the results of prominent “wandering American” cases such as the shoot-down of Korean Air 007 or the hijacking of Air France 139. It comments on how the law is rapidly evolving as federal courts wrestle with whether Federal Rule of Civil Procedure 4(k)(2) can better address the lack of “minimum contacts” carriers have with most U.S. states and the lack of causal connections between forum and claims. Finally, it considers how Congress or American aviation authorities can better align Montreal’s promise of a “fifth jurisdiction” with American jurisdictional law.
Türkiye’de Satın Alma Gücü Paritesi Teorisinin Güçlü ve Zayıf Formda Geçerliliği: ARDL ve Birim Kök Testlerinden Kanıtlar
Authors: Karataş Ali Rauf
Published: July 2024

İktisat ve uluslararası finans yazınında, iki veya daha fazla para biriminin değerlerini karşılaştırmak için çokça atıf alan yaklaşımlardan biri satın alma gücü paritesi (SAGP) teorisidir. Bu çalışma, Türkiye’de SAGP teorisinin uzun dönemde geçerliliğini, güçlü ve zayıf formda olmak üzere iki açıdan sınamak amacıyla yapılmıştır. 1994:1-2023:10 dönemi aylık verilerinin kullanıldığı bu çalışmada, SAGP teorisinin güçlü formda sınanması için Genişletilmiş Dickey-Fuller (ADF) ve Kesirli Frekanslı Fourier ADF birim kök testleri kullanılmıştır. SAGP teorisinin geçerliliği zayıf formda sınanırken ise ARDL Sınır Testi analiz aracı olarak kullanılmıştır. Çalışmada elde edilen sonuçlara göre Türkiye’de söz konusu dönemde, SAGP teorisinin hem güçlü hem de zayıf formda geçerli olduğu tespit edilmiştir. Elde edilen ampirik bulgular Türkiye ekonomisinde nominal döviz kurları ile ulusal ve uluslararası göreli fiyat seviyeleri arasında uzun dönemli bir ilişkinin varlığını göstermiştir. Buna göre 1980 sonrası dönemde dışa açılma ve ekonomik entegrasyon sürecine giren Türkiye ekonomisi, parasal iktisat bağlamında uluslararasılaşma sürecini tamamlamış ve küresel ekonomik sisteme entegre olmuştur.
Birey Davranışlarının Kurum ve Kuruluşlar Üzerindeki Etkisi: Ülgener ve Le Bon’un Fikirleri Üzerinden Türkiye için Bir Analiz
Authors: Kılıç Mustafa Ercan
Published: July 2024

Bu çalışmanın amacı, kurumlardaki ve kuruluşlardaki değişimin neden ve nasıl yapılması gerektiğini tartışarak Türkiye’nin gelişimi için ihtiyacı olan kurumsal/kuruluşsal güce nasıl kavuşacağına dair bir kanaat ortaya koymaktır. Yapılan araştırmada, Türkiye’de kurumların/kuruluşların ekonomi için neden olumsuz etkiler oluşturduğu Sabri Ülgener’ in ve Gustave Le Bon’ un tespitleri üzerinden değerlendirilmiştir. Sonuç olarak Türkiye’nin muasır medeniyetler seviyesine yükselmesi için gerekli olan kurumsal/kuruluşsal güce ulaşma hedefinde, usul noktasında tekrar eden hataları tespit edilmiştir. Günümüze gelinceye kadar Türkiye kendi dinamikleriyle uyumlu ve ihtiyacına göre özgün bir kurumsal/kuruluşsal yapı oluşturamamıştır. Yanlış usullerle ve usulsüzlük ile ortaya çıkan kurumlar/kuruluşlar, toplumu rasyonalize etmekten ziyade bireysel irrasyonelliklerin temsilcisi ve hatta tebliğcisi konumuna gelmiştir. Bireylerin irrasyonel davranışları kurumlara/kuruluşlara hâkim olmuştur. Bir de Türkiye’nin istikrarsız ve toplumu kutuplaştıran siyasi yapısı bu türlü davranışları, halk nezdinde haklı göstermiş ve derinleşmesine yol açmıştır.
Esgotamento físico e mental de residentes multiprofissionais em um hospital de referência no Pará durante a pandemia da COVID-19
Authors: Oliveira-da-Silva Pâmela , Chaves Lígia Gizely dos Santos , Galvão Edna Ferreira Coelho , Cortinhas-Alves Erik Artur
Published: July 2024

Objetivo: Avaliar como a QV da população de residentes multiprofissionais de um hospital de referência em Belém - Pará foi afetada durante pandemia da covid-19. Métodos: A amostra foi constituída por 69 residentes. Os residentes foram entrevistados com a ajuda de um questionário elaborado com três blocos de questões: o bloco 1 continha questões relativas à idade, sexo, profissão e especialidade de formação, o bloco 2 era o questionário previamente validado da Organização Mundial de Saúde para Qualidade de Vida WHOQOL-Bref e o bloco 3 versava sobre questões socioepidemiológicas. Resultados: Os residentes multiprofissionais apresentaram um nível insatisfatório em relação à qualidade de vida (psicológico=41.3±13.7, físico=45.6±14.9, relações sociais=49.9±17.9, ambiente=43,3±14.6 e total=43,6±11.7). O domínio psicológico foi significativamente menor (p=0.0325) no grupo das mulheres. Não houve diferença significativa na qualidade de vida entre os residentes de diferentes especialidades. Conclusão: Os escores de QV mensurados por meio do WHOQOL-bref foram baixos em todos os domínios, sendo o pior o psicológico.
Study on Natural Gums and Resins as Release Retarding Agents in Development of Sustained Release Matrix Tablets of Didanosine
Authors: Muzib Y  Indira , Swetha K , Ambedkar YR
Published: July 2024

Didanosine is an anti-retroviral drug which helpful in preventing human immunodeficiency virus (HIV) from multiplication in the body. This drug has a relatively short half-life and low absolute bioavailability and requires frequent dosing. So to avoid this frequent dosing and to improve the patient’s compliance, the development of sustained-release tablets is necessary. Natural gums and resins play an important role in retarding drug release. Didanosine extended-release matrix formulations developed with wet granulation using gum kondagogu, guar gum, gum olibanum, and olibanum resin, and evaluated for pre and post-compression parameters. The outcome of all evaluation tests is reached IP specifications. Formulations with kondagogu F1-F3 failed to extend the drug release. F4-F6 was formulated with gum kondagogu and guar gum, in which F4 prolonged the release up to 12 hours with 98.23%. The formulations F7 with olibanum resin release 96.13%, and F10 with gum olibanum releases 93.15% drug at the end of 12 hours. The conclusion from the study was that natural polymers could be used to enhance drug release for an extended period.
Development and Assessment of Phytosomes for the Treatment of Polycystic Ovarian Syndrome
Authors: Tiwari Gaurav , Rao Desu Brahma  Srinivasa , Singh Gurinderdeep , Rao NG  Raghavendra
Published: July 2024

Phytosomes, a novel drug delivery system, have gained attention for their potential in the treatment of polycystic ovarian syndrome (PCOS). Polycystic ovaries, unpredictable menstrual cycles, and hormonal imbalances are the hallmarks of PCOS, a frequent endocrine disorder affecting women of reproductive age. The main aim is to prepare and evaluate phytosomes for the treatment of PCOS. The materials used were guggul from Commiphora mukul, berberine from Berberis vulgaris and green tea from Camellia sinensis. All the phytosomal formulations are prepared in ratios and further evaluated. Phytosomal screening confirms the presence of required phytosomes like alkaloids, tannins and saponins that are effective in treating PCOS. Fourier-transform infrared spectroscopy (FTIR) evaluation was performed and ex-vivo and sub-acute toxicity evaluation confirms that formulation, PY4: Soy lecithin at a 3:1 extract ratio exhibited a greater release profile without any harm. As per the findings of this study, employing optimized phytosome-based medication delivery as bio-enhancers may enhance the bioavailability of herbal extract.
Formulation Optimization and Evaluation of Herbal Films Containing Ethanol Leaves Extract of Cassia auriculata to Treat Chronic Constipation Disorder
Authors: Bonthagarala Brahmaiah , Alla Seetha  Devi , Nagineni Sudarshan Rao , Vadapalli Rama  Rao , Malakapurapu Sri  Rekha
Published: July 2024

An intriguing trend in recent years has been the designing of oral films containing extracts from medicinal plants. Therefore, efforts were made in the current work to create fast-dissolving herbal films using Cassia auriculata ethanol leaf extract in order to create a dosage form that would be more convenient to administer and treat chronic constipation disorders in the elderly. Varying ratios of hydroxy propyl methyl cellulose as polymer, propylene glycol as film softener, and a solvent-casting approach were utilized to create the quickly dissolving herbal films of C. auriculata leaf extract. A number of quality control measures, including weight fluctuation, thickness variation, surface pH, percentage moisture uptake, percentage moisture loss, disintegration time and folding endurance, were assessed. According to the findings, every film had a decent appearance, a smooth texture, was free of particle matter, and had excellent folding endurance. According to a content uniformity analysis, the drug is dispersed evenly across the entire film, and each one dissolves in less than 95 seconds. In-vitro dissolving studies using Paddle type apparatus in pH 6.8 phosphate buffer pH 6.8, which is simulated saliva, were performed for each film composition. Out of all nine formulations, formulation F5, which is an herbal film with 10% propylene glycol and 40% HPMC, exhibited complete drug release (99.6%) in 30 minutes and had a strong folding endurance value. The release of medication from films was found to follow a first-order kinetics. Overall, studies indicate that the most feasible dose form that can be used in medical settings for the treatment of chronic constipation disorder is fast-dissolving herbal films containing C. auriculata leaves extract. This is especially true for patients who have difficulty swallowing.
Estimation of Imeglimin in Pharmaceutical Tablets by RP-HPLC
Authors: Jahagirdar Shubham , Godge Rahul , Vikhe Sneha , Bornare Snehal
Published: July 2024

Objective: This study’s primary goal is to create a novel, sensitive and comprehensive reverse phase-high performance liquid chromatography (RP-HPLC) procedure. The computation of Imeglimin’s dose and dosage is the primary goal. Method: Chemicals and impurities were separated chromatographically using a C18 (AGILENT) chromatographic column. Methanol and 0.1% OPA are present in the mobile phase in a 40:60 v/v ratio. A 240 nm ultraviolet light detector was employed for the purpose of detection. With a retention time of 4.718 minutes, the results demonstrated the effectiveness of meglimin. After adjusting the flow rate to 0.7 mL/min, there was good separation. There are several imeglimin doses planned, ranging from 10 to 50 μg/mL. 101.46 to 101.12% in yield. Results: This method’s validation has good accuracy, sensitivity, precision, linearity, specificity, and robustness, and it satisfies the requirements of the International Conference on Harmonization. Conclusion: In conclusion, imeglimin was predicted and the construction method was isolated. In conclusion, it’s feasible for daily use.
Study of Total Phenols, Flavonoids, Antioxidant and Antibacterial Activities from Dioscorea hispida Tubers
Authors: . Masfria , H Syahputra , VC Samosir , E Manalu
Published: July 2024

The tubers of Dioscorea hispida Dennst., a Dioscoreaceae plant, contain flavonoid molecules and plant secondary metabolites that are antioxidants and antibacterials. In this study, the total phenolic content and flavonoids from the ethanol extract and fraction (n-hexane and ethyl acetate) of Dioscorea tuber were investigated for their antioxidant and antibacterial properties. Fractionation with n-hexane and ethyl acetate followed by diffusion with 96% ethanol. The Folin-Ciocalteau reagent measured total phenol at 765 nm, and the AlCl3 method measured total flavonoid at 440 nm using a visible spectrophotometer. The DPPH assessed the antioxidant activity, whereas the antibacterial activity against Staphylococcus aureus and Escherichia coli was determined using agar diffusion on paper discs. The extract, n-hexane fraction, and ethyl acetate exhibited total phenolic content of 33.02, 5.95, and 156.33 mg GAE/g extract, respectively. Similarly, the total flavonoid content was measured at 20.26, 14.31, and 74.02 mg QE/g extract. The extract, n-hexane fraction, and ethyl acetate of the Dioscorea tuber exhibited minimum inhibitory concentrations (MICs) of 8.25, 7.76, and 10.30 mg/mL against S. aureus and 8.51, 8.31, and 12.05, against E. coli, respectively. The findings of this study indicate that the ethanol extract and n-hexane fraction derived from Dioscorea tubers exhibited comparatively diminished antioxidant and antibacterial properties in comparison to the ethyl acetate fraction. Furthermore, the ethyl acetate fraction exhibited elevated concentrations of total phenols and total flavonoids in comparison to the remaining fractions.
Bioanalytical Method Development and Validation for Determination of Nirmatrelvir in Human Plasma using LC-MS/MS
Authors: Jabeen MSNameera , Haque M Akiful
Published: July 2024

The term “antivirals” has been associated with COVID-19 during the period when the usage of this specific class of medications has increased. Nirmatrelvir, a protease inhibitor, is used to treat mild to moderate COVID-19 symptoms by stopping SARS-COV-2 reproduction. With deucravacitinib serving as the internal standard, liquid chromatography-tandem mass spectroscopy in human plasma was used to provide a quick, simple, innovative, trustworthy, and sensitive approach. Liquid-liquid extraction was used to separate nirmatrelvir and the internal standard. The extracted sample was then run through a chromatographic system with ACE-C18 column (4.6 × 100 mm, 5 μm); and mobile phase with methanol and 2 mM ammonium formate in a ratio of 80:20, and a flow rate of 1.00 mL/min. The system operates for three minutes in multiple reaction monitoring mode at the ABSCIEX API 4000 mass spectrometer using electron spray ionization. Nirmatrelvir ion transitions are 500.10 to 110.10, while deucravacitinib are 426.30 to 358.20. The validation was conducted using a concentration range of 5.00 to 4000 ng/mL, and the results showed that the selectivity, accuracy, precision, linearity, and selectivity were all within the acceptability limits.
Anastrozole and Paclitaxel Loaded Nanocrystals: Evaluation of Anticancer Activity
Authors: V Pavan Kumar , Harikrishnan Narayanaswamy
Published: July 2024

To study the cytotoxic study of anastrozole and paclitaxel-loaded nanocrystals on MDA-MB-231 cell lines for enhanced anticancer activity. Paclitaxel is a tubulin-targeting cytoskeletal drug that interferes with microtubule structures, and anastrozole’s mechanism of action is apoptosis in living cells. Methylthiazol tetrazolium (MTT) assay was used to determine anticancer activity. After 24 hours of treatment, the highest ALN and PLN concentrations (100 μg/mL) showed a cytotoxic effect. The inhibition rate of doxorubicin (standard) was found at 24 hours with 89.6. The viability values of Anastrozole loaded nanocrystals (ALN) were 14.03 (100), 22.76 (80), 28.23 (40), 34.9 (20), 40.26 (10), 50.13 (5), 60.53 (2), 80.66 (1), and 99.11 (0) μg/mL. When compared to the standard, viability was 38.23% and drug unloaded nanocrystal was 86.06% (100 μg/mL) 24 hours after anastrozole (100 μg/mL) administration to MDA-MB-231 cells. All experimental groups showed significantly from the control group. The cytotoxicity effect was determined with low dose of anastrozole and paclitaxel-loaded nanocrystals. The cell viability and toxic effects of the ALN and PLN also tested. As ALN and PLN concentrations grew, so did the harmful effect on MDA-MB-231 cell viability. Cell count was significantly reduced (p < 0.05) at high ALN and PLN concentrations (100 μg/mL). Finally, the MTT assay revealed that ALN and PLN cytotoxic to MDA- MB-231. Exposure to dose-dependently hazardous doses of ALN and PLN nanocrystal formulations resulted in increased nuclear intensity, cytochrome c, and permeability of the cell membrane in the MDA-MB-231 cell line.
Chemical Composition and Antioxidants of Senecio vulgaris (Asteraceae)
Authors: Qader Karzan Omer
Published: July 2024

The study included the antioxidant and chemical compounds of methanolic extract of Senecio vulgaris in Iraq. S. vulgaris has a rich history in traditional medicine for treating different health problems. The results gas chromatography-mass spectrometry (GC-MS) chromatogram of S. vulgaris extract showed 19 peaks, which indicates the presence of 19 compounds (phytochemical constituents). Most of the chemical components extracted from S. vulgaris include oleic acid (40.46%), n-Hexadecanoic acid (23.40%), 5,9-dimethyl-2-(1-methylethyl)-1-cyclodecanone (6.52%), octadecanoic acid (3.57%) and 1,2-benzenedicarboxylic acid, bis(2-methylpropyl) ester (3.27%). The antioxidant activity of overall methanol extract contents of S. vulgaris was determined by adding different concentrations of methanol extract to 2,2-diphenyl-1-picrylhydrazyle (DPPH). The inhibitory activity was evaluated by using five different concentrations of methanol extract of S. vulgaris. The results showed that the antioxidant activity in concentration 3 μL/mL was 41.23%, while the highest antioxidant activity was 98.33% in 25 μL/mL compared with vitamin C, which was 16% in 3 μL/mL and recorded 91.97% in 25 μL/mL. The total antioxidant capacity of S. vulgaris methanol extract was evaluated as vitamin C equivalents per gram. The DPPH radical scavenging potency with a minimum IC50 value in S. vulgaris was 5.64 μL/mL, while vitamin C was 3.09.