bluuebunny/crossref_metadata_2025 huggingface dataset:
OLIA: An open-source digital lock-in amplifier
Authors: Harvie Andrew J. , de Mello John C.
Published: March 2023

The Open Lock-In Amplifier (OLIA) is a microcontroller-based digital lock-in amplifier built from a small number of inexpensive and easily sourced electronic components. Despite its small credit card-sized form-factor and low build-cost of around US$35, OLIA is a capable instrument that offers many features associated with far costlier commercial devices. Key features include dual-phase lock-in detection at multiple harmonic frequencies up to 50 kHz, internal and external reference modes, adjustable levels of input gain, a choice between low-pass filtering and synchronous filtering, noise estimation, and a comprehensive programming interface for remote software control. OLIA comes with an optional optical breakout board that allows noise-tolerant optical detection down to the 40-pW level. OLIA and its breakout board are released here as open hardware, with technical diagrams, full parts-lists, and source-code for the firmware.
The standards of reporting randomized trials in pets (PetSORT): Methods and development processes
Authors: Ruple Audrey , Sargeant Jan M. , Selmic Laura E. , O'Connor Annette M.
Published: March 2023

Background

Reporting of clinical trials conducted in client- and shelter-owned dog and cat populations is not optimal, which inhibits the ability to assess the reliability and validity of trial findings and precludes the ability to include some trials in evidence synthesis.

Objective

To develop a reporting guideline for parallel group and crossover trials that addresses the unique features and reporting requirements for trials conducted in client- and shelter-owned dog and cat populations.

Design

Consensus statement.

Setting

Virtual.

Participants

Fifty-six experts from North America, the United Kingdom, Europe, and Australia working in academia, government (research and regulatory agencies), industry, and clinical veterinary practice.

Methods

A steering committee created a draft checklist for reporting criteria based upon the CONSORT statement and the CONSORT extensions for reporting of abstracts and crossover trials. Each item was presented to the expert participants and was modified and presented again until >85% of participants were in agreement about the inclusion and wording of each item in the checklist.

Results

The final PetSORT checklist consists of 25 main items with several sub-items. Most items were modifications of items contained in the CONSORT 2010 checklist or the CONSORT extension for crossover trials, but 1 sub-item pertaining to euthanasia was created de novo.

Conclusion

The methods and processes used to develop this guideline represent a novel departure from those used to create other reporting guidelines, by using a virtual format. The use of the PetSORT statement should improve reporting of trials conducted in client- and shelter-owned dogs and cats and published in the veterinary research literature.
The standards of reporting trials in pets (PetSORT): Explanation and elaboration
Authors: Sargeant Jan M. , Ruple Audrey , Selmic Laura E. , O'Connor Annette M.
Published: March 2023

Well-designed randomized controlled trials (RCTs) provide the best evidence of the primary research designs for evaluating the effectiveness of interventions. However, if RCTs are incompletely reported, the methodological rigor with which they were conducted cannot be reliably evaluated and it may not be possible to replicate the intervention. Missing information also may limit the reader's ability to evaluate the external validity of a trial. Reporting guidelines are available for clinical trials in human healthcare (CONSORT), livestock populations (REFLECT), and preclinical experimental research involving animals (ARRIVE 2.0). The PetSORT guidelines complement these existing guidelines, providing recommendations for reporting controlled trials in pet dogs and cats. The rationale and scientific background are explained for each of the 25 items in the PetSORT reporting recommendations checklist, with examples from well-reported trials.
Advances in Cathodes for High-Performance Magnesium-Sulfur Batteries: A Critical Review
Authors: Yao Ying Ying , Zhan Yang , Sun Xin Yu , Li Zhao , Xu Hao , Laine Richard M. , Zou Jian Xin
Published: March 2023

Large-scale energy storage with high performance and at a reasonable cost are prerequisites for promoting clean energy utilization. With a high theoretical energy density of 1722 Wh·kg−2, high element abundance (e.g., Mg of 23,000 ppm, S of 950 ppm on earth), and low theoretical cost, Mg-S batteries offer considerable potential as candidates for electrical energy storage. However, due to the intrinsic complex reaction chemistry of sulfur cathodes and metal anodes, such as slow diffusion of the divalent ion, the shuttle of soluble polysulfide, and irreversible deposition of Mg ions on metal electrodes, Mg-S batteries still need further optimization to meet requirements for practical applications. In addition to stabilizing metal anodes, developing a suitable sulfur cathode is desperately needed. This review summarizes recent research progress in sulfur cathodes, interlayers, and non-nucleophilic electrolytes, highlighting the main challenges and corresponding strategies for electrode material designs. Notably, we emphasize a fundamental understanding of the structure-composition relationship. Furthermore, state-of-the-art characterization techniques are described that help reveal the pertinent electrochemical mechanisms whereby Mg-S cells function. Finally, possible research directions are discussed.
Three-Month Outcomes in Cancer Patients with Superficial or Deep Vein Thrombosis in the Lower Limbs: Results from the RIETE Registry
Authors: Debourdeau Philippe , Bertoletti Laurent , Font Carme , López-Núñez Juan José , Gómez-Cuervo Covadonga , Mahe Isabelle , Otero-Candelera Remedios , Adarraga Maria Dolores , López-Miguel Patricia , Monreal Manuel ,   RIETE Investigators
Published: March 2023

Background: The clinical characteristics and outcomes of cancer patients with lower-limb isolated superficial vein thrombosis (SVT) have not been consistently evaluated. Methods: We used data in the RIETE registry to compare the clinical characteristics and 90-day outcomes for patients with: (1) active cancer and lower-limb SVT; (2) active cancer and lower-limb deep vein thrombosis (DVT); (3) lower-limb SVT without cancer. The primary outcomes included subsequent symptomatic SVT, DVT or pulmonary embolism (PE). Secondary outcomes were major bleeding and death. Results: From March 2015 to April 2021, there were 110 patients with cancer and SVT, 1695 with cancer and DVT, and 1030 with SVT but no cancer. Most patients in all subgroups (93%, 99% and 96%, respectively) received anticoagulants, while those with SVT received lower daily doses of low-molecular-weight heparin (114 ± 58, 163 ± 44, and 106 ± 50 IU/kg, respectively). During the first 90 days, 101 patients (3.6%) developed subsequent VTE (PE 47, DVT 41, SVT 13), whereas 72 (2.5%) had major bleeding and 282 (9.9%) died. Among the three groups, 90-day events were, respectively: VTE at rates of 7.3%, 4.0% and 2.4%; major bleeding at rates of 2.7%, 3.9% and 0.3%; mortality at rates of 8.2%, 16% and 0.3%. Between D90 and D180, only one SVT recurrence and one death occurred in SVT cancer patients. In multivariable analysis, cancer was associated with subsequent VTE (HR = 2.04; 1.15–3.62), while initial presentation as SVT or DVT were not associated with a different risk. Conclusions: The risk for subsequent VTE (including symptomatic SVT, DVT or PE) was similar in cancer patients with isolated SVT than in those with isolated DVT.
SPOCK1 Overexpression Suggests Poor Prognosis of Ovarian Cancer
Authors: Váncza Lóránd , Horváth Anna , Seungyeon Lee , Rókusz András , Dezső Katalin , Reszegi Andrea , Petővári Gábor , Götte Martin , Kovalszky Ilona , Baghy Kornélia
Published: March 2023

Purpose: Sparc/osteonectin, cwcv, and kazal-like domains proteoglycan 1 (SPOCK1) has been found in a variety of malignant tumors and is associated with a poor prognosis. We aimed to explore the role of SPOCK1 in ovarian cancer. Methods: Ovarian cancer cell lines SKOV3 and SW626 were transfected with SPOCK1 overexpressing or empty vector using electroporation. Cells were studied by immunostaining and an automated Western blotting system. BrdU uptake and wound healing assays assessed cell proliferation and migration. SPOCK1 expression in human ovarian cancer tissues and in blood samples were studied by immunostaining and ELISA. Survival of patients with tumors exhibiting low and high SPOCK1 expression was analyzed using online tools. Results: Both transfected cell lines synthesized different SPOCK1 variants; SKOV3 cells also secreted the proteoglycan. SPOCK1 overexpression stimulated DNA synthesis and cell migration involving p21CIP1. Ovarian cancer patients had increased SPOCK1 serum levels compared to healthy controls. Tumor cells of tissues also displayed abundant SPOCK1. Moreover, SPOCK1 levels were higher in untreated ovarian cancer serum and tissue samples and lower in recipients of chemotherapy. According to in silico analyses, high SPOCK1 expression was correlated with shorter survival. Conclusion: Our findings suggest SPOCK1 may be a viable anti-tumor therapeutic target and could be used for monitoring ovarian cancer.
Current Treatment Practices and Prognostic Factors in Early-Stage Ovarian Cancer—An Analysis of the NOGGO/JAGO
Authors: Heublein Sabine , Baum Joanna , Jaeger Anna , Grimm-Glang Donata , Olthoff Julia , Braicu Elena Ioana , Azzam Nieto Osama , Hassdenteufel Kathrin , Schmalfeldt Barbara , Hanker Lars , Wallwiener Markus , Schneeweiss Andreas , Sehouli Jalid , Pietzner Klaus
Published: March 2023

Background: Surgery is the backbone of early-stage ovarian cancer (OC) management. However, in practice, there is disagreement about the extent of surgical staging and whether additional adjuvant treatment should be provided. As omitting relevant diagnostic or therapeutic procedures might lead to undertreatment, we aimed to structurally investigate treatment practice in addition to prognostic factors in a multicentre series of patients (pts) diagnosed with early-stage OC. Patients: Within this retrospective, multicentre study, medical records of 379 pts who had undergone surgery for suspected early-stage OC between January 2014 and March 2020 were analysed. Results: Of the 379 patients, 292 had pT stage 1a-2a and had complete data on the extent of surgical staging. At least one surgical step was omitted in 100 pts (34.2%). Complete surgical staging (n = 192; (65.8%)) was more often performed in high-grade serous OC and was independent of the healthcare level of the hospital where the initial diagnosis was made. Missing to take peritoneal biopsies was associated with reduced relapse-free-survival in incompletely staged, pT1 cases (p = 0.03). About every second patient (46.7%) with a final stage lower than FIGO IIB and treated with adjuvant chemotherapy received combination chemotherapy. BRCA1 and BRCA2 testing was only performed in a subset of pts, and mutations were detected in 18% (14/79) and 9% (7/85) pts, respectively. Conclusions: This study helps to increase our understanding of early-stage OC treatment and prognosis. In addition to treating patients in compliance with current guidelines, the need for BRCA testing should also be considered for early-stage OC.
The Role of Mammalian STK38 in DNA Damage Response and Targeting for Radio-Sensitization
Authors: Fukasawa Takemichi , Enomoto Atsushi , Yoshizaki-Ogawa Asako , Sato Shinichi , Miyagawa Kiyoshi , Yoshizaki Ayumi
Published: March 2023

Protein kinases, found in the nucleus and cytoplasm, play essential roles in a multitude of cellular processes, including cell division, proliferation, apoptosis, and signal transduction. STK38 is a member of the protein kinase A (PKA)/PKG/PKC family implicated in regulating cell division and morphogenesis in yeast and C. elegans. However, its function remained largely unknown in mammals. In recent years, advances in research on STK38 and the identification of its substrates has led to a better understanding of its function and role in mammals. This review discusses the structure, expression, and regulation of activity as a kinase, its role in the DNA damage response, cross-talk with other signaling pathways, and its application for radio-sensitization.
The Matrix Reloaded—The Role of the Extracellular Matrix in Cancer
Authors: Raskov Hans , Gaggar Shruti , Tajik Asma , Orhan Adile , Gögenur Ismail
Published: March 2023

As the core component of all organs, the extracellular matrix (ECM) is an interlocking macromolecular meshwork of proteins, glycoproteins, and proteoglycans that provides mechanical support to cells and tissues. In cancer, the ECM can be remodelled in response to environmental cues, and it controls a plethora of cellular functions, including metabolism, cell polarity, migration, and proliferation, to sustain and support oncogenesis. The biophysical and biochemical properties of the ECM, such as its structural arrangement and being a reservoir for bioactive molecules, control several intra- and intercellular signalling pathways and induce cytoskeletal changes that alter cell shapes, behaviour, and viability. Desmoplasia is a major component of solid tumours. The abnormal deposition and composition of the tumour matrix lead to biochemical and biomechanical alterations that determine disease development and resistance to treatment. This review summarises the complex roles of ECM in cancer and highlights the possible therapeutic targets and how to potentially remodel the dysregulated ECM in the future. Furthering our understanding of the ECM in cancer is important as the modification of the ECM will probably become an important tool in the characterisation of individual tumours and personalised treatment options.
Consensus for Flow Cytometry Clinical Report on Multiple Myeloma: A Multicenter Harmonization Process Merging Laboratory Experience and Clinical Needs
Authors: Cordone Iole , Amodeo Rachele , Bellesi Silvia , Bottan Fiorella , Buccisano Francesco , De Propris Maria Stefania , Masi Serena , Panichi Valentina , Scerpa Maria Cristina , Annibali Ombretta , Bongarzoni Velia , Caravita di Toritto Tommaso , Coppetelli Ugo , Cupelli Luca , de Fabritiis Paolo , Franceschini Luca , Garzia Mariagrazia , Fiorini Alessia , Laverde Giacinto , Mengarelli Andrea , Za Tommaso , Petrucci Maria Teresa
Published: March 2023

Flow cytometry is a highly sensitive and specific approach for discriminating between normal and clonal plasma cells in multiple myeloma. Uniform response criteria after treatment have been established by the International Myeloma Working Group and the EuroFlow Group; however, the way in which flow cytometry data are reported has suffered from no collaborative or multicentre efforts. This study, involving 8 expert laboratories and 12 clinical hematology units of the Lazio region in Italy, aims to produce a uniform and shared report among the various Centres. From the pre-analytical phase to sample processing, data acquisition, analysis, and evaluation of the potential limitations and pitfalls of the entire process, the study reaches a final conclusion shared by laboratories and clinicians according to the most updated principles and recommendations. The aim was to identify the necessary data to be included in the clinical report by using multiple-choice questionnaires at every single stage of the process. An agreement of more than 75% of the laboratories was considered mandatory for the data to be included in the report. By ensuring the operational autonomy of each laboratory, this study provides a clear report that limits subjective interpretations and highlights possible bias in the process, better supporting clinical decision-making.
Follow-Up Imaging Guidelines for Patients with Stage III Unresectable NSCLC: Recommendations Based on the PACIFIC Trial
Authors: Ko Jenny J. , Banerji Shantanu , Blais Normand , Brade Anthony , Clelland Cathy , Schellenberg Devin , Snow Stephanie , Wheatley-Price Paul , Yuan Ren , Melosky Barbara
Published: March 2023

The PACIFIC trial showed a survival benefit with durvalumab through five years in stage III unresectable non-small cell lung cancer (NSCLC). However, optimal use of imaging to detect disease progression remains unclearly defined for this population. An expert working group convened to consider available evidence and clinical experience and develop recommendations for follow-up imaging after concurrent chemotherapy and radiation therapy (CRT). Voting on agreement was conducted anonymously via online survey. Follow-up imaging was recommended for all suitable patients after CRT completion regardless of whether durvalumab is received. Imaging should occur every 3 months in Year 1, at least every 6 months in Year 2, and at least every 12 months in Years 3–5. Contrast computed tomography was preferred; routine brain imaging was not recommended for asymptomatic patients. The medical oncologist should follow-up during Year 1 of durvalumab therapy, with radiation oncologist involvement if pneumonitis is suspected; medical and radiation oncologists can subsequently alternate follow-up. Some patients can transition to the family physician/community primary care team at the end of Year 2. In Years 1–5, patients should receive information regarding smoking cessation, comorbidity management, vaccinations, and general follow-up care. These recommendations provide guidance on follow-up imaging for patients with stage III unresectable NSCLC whether or not they receive durvalumab consolidation therapy.
Prognosis after Local Recurrence in Patients with Early-Stage Breast Cancer Treated without Chemotherapy
Authors: Sopik Victoria , Lim David , Sun Ping , Narod Steven A.
Published: March 2023

Background: Many women with early-stage breast cancer are predicted to be at sufficiently low risk for recurrence that they may forego chemotherapy. Nevertheless, some low-risk women will experience a local recurrence, and for them the risk of death increases significantly thereafter. The utility of initiating chemotherapy at the time of local recurrence has not been adequately addressed. The purpose of this study is to identify, in a hospital-based series of patients with early-stage breast cancer who were not treated with chemotherapy, those factors which predict death post local recurrence. Methods: We identified 135 women who were diagnosed with early-stage breast cancer (node-negative, <5 cm) and who did not receive chemotherapy at diagnosis and who developed a local recurrence. They were diagnosed between 1987 and 2000 and treated at Women’s College Hospital. For each patient, we abstracted information on the initial cancer (age at diagnosis, tumour size, tumour grade, ER status, PR status, HER2 status, lympho-vascular invasion, type of surgery, use of radiotherapy, tamoxifen and chemotherapy), the time from initial diagnosis to local recurrence and treatment at recurrence. The Kaplan–Meier method was used to estimate the ten-year actuarial risk of breast cancer death post recurrence. A Cox proportional hazards model was used to estimate multivariate hazard ratios for the various factors. Results: Among the 135 women in the cohort, the mean time from initial diagnosis to local recurrence was 7.8 years (range: 0.3 to 22.6 years). A total of 38 of the 135 women (28.1%) died of breast cancer a mean of 5.3 years after experiencing the local recurrence (range: 0.3 to 17 years). The ten-year breast cancer survival post local recurrence was 71% and the 15-year survival was 65%. In a multivariate analysis, it was found that factors that were significantly associated with death after local recurrence were (1) PR-negative status, (2) young age at diagnosis (<40 years) and (3) time to local recurrence less than 2 years. Nine percent of women received chemotherapy at the time of local recurrence. Conclusions: For breast cancer patients with a low baseline risk of mortality, the risk of death after an isolated local recurrence is substantial. Systemic treatment at the time of local recurrence needs further study.
Assessing the Comprehensive Training Needs of Informal Caregivers of Cancer Patients: A Qualitative Study
Authors: Papadakos Janet , Ugas Mohamed , Quartey Naa Kwarley , Papadakos Christine (Tina) , Giuliani Meredith Elana
Published: March 2023

Introduction: The increasing demand for cancer services is projected to overwhelm the cancer care system, leading to a potential shortfall in human resource capacity. Informal caregivers (unpaid family/friend caregivers of cancer patients) provide a significant amount of care to patients and the cancer care system could not cope without them. The aim of this study was to analyze the needs of informal caregivers (CGs) through interviews with cancer patients and CGs, and to assess the content and utility of a comprehensive caregiver training course. Methods: Cancer patients and CGs were recruited from an academic cancer centre to elicit their thoughts and perceptions of cancer CG education needs through a qualitative, phenomenological design using semi-structured interviews and a curriculum review activity. Results: Six patients and seven CGs were interviewed. Patients averaged 53.8 years of age and CGs averaged 53.1 years. Caregiver participants reported that they were unprepared for their caregiving role. Depending on the severity of the disease, CGs reported significant emotional strain. Most participants wanted more practical information, and all expressed the desire for greater social support for CGs. While there were differences in terms of desired modality (e.g., online, in-person), support for greater CG education was strong. Discussion: CGs experience a significant learning curve and receive little to no direct training or education to help them acquire the knowledge and skills they need to support a cancer patient. This is especially challenging for new CGs, for whom emotional and informational needs are particularly acute. Participants shared a great deal of endorsement for a comprehensive training course for new CGs. Given the multiple demands on their time, some participants suggested that consideration be made to establish synchronous classes. Participants held that having the course take place (online or in-person) at a specific time, on a specific date could help CGs prioritize their learning. Participants also endorsed the idea of “required” learning because even though CGs may recognize that a course could be beneficial, some may lack the motivation to participate unless it was “prescribed” to them by a healthcare provider.
Lossy State Communication over Fading Multiple Access Channels
Authors: Ramachandran Viswanathan
Published: March 2023

Joint communications and sensing functionalities integrated into the same communication network have become increasingly relevant due to the large bandwidth requirements of next-generation wireless communication systems and the impending spectral shortage. While there exist system-level guidelines and waveform design specifications for such systems, an information-theoretic analysis of the absolute performance capabilities of joint sensing and communication systems that take into account practical limitations such as fading has not been addressed in the literature. Motivated by this, we undertake a network information-theoretic analysis of a typical joint communications and sensing system in this paper. Towards this end, we consider a state-dependent fading Gaussian multiple access channel (GMAC) setup with an additive state. The state process is assumed to be independent and identically distributed (i.i.d.) Gaussian, and non-causally available to all the transmitting nodes. The fading gains on the respective links are assumed to be stationary and ergodic and available only at the receiver. In this setting, with no knowledge of fading gains at the transmitters, we are interested in joint message communication and estimation of the state at the receiver to meet a target distortion in the mean-squared error sense. Our main contribution here is a complete characterization of the distortion-rate trade-off region between the communication rates and the state estimation distortion for a two-sender GMAC. Our results show that the optimal strategy is based on static power allocation and involves uncoded transmissions to amplify the state, along with the superposition of the digital message streams using appropriate Gaussian codebooks and dirty paper coding (DPC). This acts as a design directive for realistic systems using joint sensing and transmission in next-generation wireless standards and points to the relative benefits of uncoded communications and joint source-channel coding in such systems.
Improving Energy Access in Low-Income Sub-Saharan African Countries: A Case Study of Malawi
Authors: Ehimen Ehiaze Augustine , Sandula Peter Yamikani , Robin Thomas , Gamula Gregory Tsonga
Published: March 2023

The inaccessibility of modern energy in low-income countries (LIC), especially in the Sub-Saharan African (SSA) region, continues to be a problem in the 21st century. The lack of access to modern energy has led to an inability to implement developmental structures and initiatives. While considerable progress and successes have been realised in the last three decades with increased activities and global commitments from international governments and multinational agencies through electrification projects in the SSA region, SSA countries remain off-track in their efforts to achieve the UN Sustainable Development Goal (SDG) 7. This is mainly demonstrated in sparsely populated rural regions where the high cost of centralised power generation, poor transmission and distribution infrastructures and economic factors have been a major barrier to electricity expansion. Although the use of RES (i.e., decentralised or stand-alone systems) have been acknowledged by the International Energy Agency (IEA) to be the least expensive route to improving access, its impact has not been effectively demonstrated regionally. Decentralised RES use in SSA countries have not seen significant uptake and/or enjoyed long-term sustainability owing to a number of factors. Malawi, despite its significant hydropower resources and the favourable proximity of its inhabitants to grid infrastructures, still has one of the lowest levels of access to electricity globally, with 86% of the population having no access to electricity. The country provides a good case study to investigate factors limiting electricity access in SSA countries. This paper explores the main issues that have historically hindered the uptake and sustainable operation of decentralised RES in the country. Recommendations to facilitate a potential improvement in RES use as a pathway to improved universal energy access are then put forward.
Design and Analysis of the Inlet Valve for the CFETR Torus Cryopump
Authors: Zhou Yaqi , Feng Hansheng , Zhang Shuo , Zhuang Ming , Zhao Ziyu
Published: March 2023

The China Fusion Engineering Test Reactor (CFETR), a superconducting magnetic confinement tokamak fusion reactor, will develop a high-performance torus cryopump to pump torus plasma exhaust gas. The inlet valve is one of the key components of the cryopump, and it is used to isolate the cryopump from the plasma for regeneration, to control the pumping speed of the cryopump, and to operate as a pressure relief valve in case of a failure, such as the cryopipe breaking inside the cryopump chamber. This paper presents a novel inlet valve. Ensuring that the design of the inlet valve meets the above requirements will be a challenge. In order to verify the reliability of the inlet valve, its critical components are analyzed and optimized by the Finite Element Method. The effect of the stroke of the inlet valve on pumping performance is then estimated by the Monte Carlo Method, and the pressure profile in the whole flow field is studied to predict the cryopump’s behavior. Finally, the seismic capacity of the optimized inlet valve is analyzed, and the mechanical performance of the inlet valve is shown to meet CFETR design criteria. These design and analysis results will provide technical support and references for the development of the CFETR torus cryopump.
Adaptive Band-Pass Filter and VMD-Esprit Based Multi-Mode Monitoring Method for Broadband Electromagnetic Oscillation in “Double High” Power Systems
Authors: Zhong Tie , Yang Heling , Sun Cong , Liu Chuang , Chen Junrui
Published: March 2023

With the development of new power systems with high proportions of renewable energy and high proportions of power electronics equipment, the influence of broadband electromagnetic oscillations in power systems is becoming more and more significant. In order to better grasp the dynamic characteristics of broadband oscillations, a new adaptive band-pass filter and VMD-Esprit based multi-modal monitoring method is proposed for broadband electromagnetic oscillation in “double high” power systems. First, based on the mode frequency and amplitude information provided by FFT mode detection, the proposed adaptive band-pass filter adaptively sets the center frequency, bandwidth, and other parameters and extracts or separates the voltage/current signal in each frequency band. Second, the filtered signals are corrected and compensated, and then the VMD modal decomposition of each frequency band signal is combined with Esprit for parameter identification so as to obtain the waveform and parameter information of each mode. Finally, the separation, correction, and parameter identification of multi-mode broadband oscillation waveforms are carried out. The experimental results show that frequency division processing can reduce the computation and improve real-time performance. In the processing of signals in the frequency band, the center frequency, bandwidth, and other parameters can be adjusted adaptively under different conditions of single-mode composition or multi-mode composition, which improves the accuracy of VMD decomposition and increases the flexibility of signal processing. Meanwhile, it overcomes the defects such as the inaccuracy of traditional mode recognition, which provides a new idea for broadband electromagnetic oscillation analysis.
A Critical Review of Polymer Electrolyte Membrane Fuel Cell Systems for Automotive Applications: Components, Materials, and Comparative Assessment
Authors: Pedicini Rolando , Romagnoli Marcello , Santangelo Paolo E.
Published: March 2023

The development of innovative technologies based on employing green energy carriers, such as hydrogen, is becoming high in demand, especially in the automotive sector, as a result of the challenges associated with sustainable mobility. In the present review, a detailed overview of the entire hydrogen supply chain is proposed, spanning from its production to storage and final use in cars. Notably, the main focus is on Polymer Electrolyte Membrane Fuel Cells (PEMFC) as the fuel-cell type most typically used in fuel cell electric vehicles. The analysis also includes a cost assessment of the various systems involved; specifically, the materials commonly employed to manufacture fuel cells, stacks, and hydrogen storage systems are considered, emphasizing the strengths and weaknesses of the selected strategies, together with assessing the solutions to current problems. Moreover, as a sought-after parallelism, a comparison is also proposed and discussed between traditional diesel or gasoline cars, battery-powered electric cars, and fuel cell electric cars, thus highlighting the advantages and main drawbacks of the propulsion systems currently available on the market.
A WGAN-GP-Based Scenarios Generation Method for Wind and Solar Power Complementary Study
Authors: Ma Xiaomei , Liu Yongqian , Yan Jie , Wang Han
Published: March 2023

The issue of renewable energy curtailment poses a crucial challenge to its effective utilization. To address this challenge, mitigating the impact of the intermittency and volatility of wind and solar energy is essential. In this context, this paper employs scenario analysis to examine the complementary features of wind and solar hybrid systems. Firstly, the study defines two types of complementary indicators that distinguish between output smoothing and source-load matching. Secondly, a novel method for generating wind and solar output scenarios based on improved Generative Adversarial Networks is presented and compared against the conventional Monte Carlo and Copula function methods. Lastly, the generated wind and solar scenarios are employed to furnish complementary features. The testing results across eight regions indicate the proposed scenario generation method proficiently depicts the historical relevance as well as future uncertainties. This study found that compared to the Copula function method, the root mean square error of the generated data was reduced by 4% and 3.4% for independent and hybrid systems, respectively. Moreover, combining these two resources in most regions showed that the total output smoothness and source-load matching level cannot be enhanced simultaneously. This research will serve as a valuable point of reference for planning and optimizing hybrid systems in China.
Isothermal Deep Ocean Compressed Air Energy Storage: An Affordable Solution for Seasonal Energy Storage
Authors: Hunt Julian David , Zakeri Behnam , Nascimento Andreas , de Jesus Pacheco Diego Augusto , Patro Epari Ritesh , Đurin Bojan , Pereira Márcio Giannini , Filho Walter Leal , Wada Yoshihide
Published: March 2023

There is a significant energy transition in progress globally. This is mainly driven by the insertion of variable sources of energy, such as wind and solar power. To guarantee that the supply of energy meets its demand, energy storage technologies will play an important role in integrating these intermittent energy sources. Daily energy storage can be provided by batteries. However, there is still no technology that can provide weekly, monthly and seasonal energy storage services where pumped hydro storage is not a viable solution. Herein, we introduce an innovative energy storage proposal based on isothermal air compression/decompression and storage of the compressed air in the deep sea. Isothermal deep ocean compressed air energy storage (IDO-CAES) is estimated to cost from 1500 to 3000 USD/kW for installed capacity and 1 to 10 USD/kWh for energy storage. IDO-CAES should complement batteries, providing weekly, monthly and seasonal energy storage cycles in future sustainable energy grids, particularly in coastal areas, islands and offshore and floating wind power plants, as well as deep-sea mining activities.
Analysis of the Interconnected Development Potential of the Oil, Gas and Transport Industries in the Russian Arctic
Authors: Katysheva Elena
Published: March 2023

This article describes the hydrocarbon reserves in the oil and gas provinces of Russia’s Arctic territory, as well as specific features of the region’s raw hydrocarbon potential. It has been noted that the implementation of Arctic hydrocarbon-associated projects requires that a unified transport and logistics system be created, with the Northern Sea Route being the basis. The factors affecting the volume of cargo transportation along the Arctic routes are presented. It has been established that the hydrocarbon extraction and liquefied natural gas production in the Russian Arctic zone is the most important factor in the formation of cargo flows along the Northern Sea Route. The most significant oil and gas projects that comprise the bulk of freight traffic flow along the Arctic transportation corridors have been reviewed. The ports, as the main element of the Arctic transport system, are described in terms of their state and infrastructure. It has been indicated that the construction, modernization, and operation of the Arctic ports are closely related to the creation of long-distance railway corridors, and the construction of new railway lines leading to the Arctic Basin ports can serve as a reliable basis for the growth of the Northern Sea Route’s cargo potential. A conclusion has been drawn about the special significance of the Murmansk region for the formation of the Arctic transport system.
Preliminary Study for the Commercialization of a Electrochemical Hydrogen Compressor
Authors: Yang Rui , Kweon Hyeokbin , Kim Kibum
Published: March 2023

A global energy shift to a carbon-neutral society requires clean energy. Hydrogen can accelerate the process of expanding clean and renewable energy sources. However, conventional hydrogen compression and storage technology still suffers from inefficiencies, high costs, and safety concerns. An electrochemical hydrogen compressor (EHC) is a device similar in structure to a water electrolyzer. Its most significant advantage is that it can accomplish hydrogen separation and compression at the same time. With no mechanical motion and low energy consumption, the EHC is the key to future hydrogen compression and purification technology breakthroughs. In this study, the compression performance, efficiency, and other related parameters of EHC are investigated through experiments and simulation calculations. The experimental results show that under the same experimental conditions, increasing the supply voltage and the pressure in the anode chamber can improve the reaction rate of EHC and balance the pressure difference between the cathode and anode. The presence of residual air in the anode can impede the interaction between hydrogen and the catalyst, as well as the proton exchange membrane (PEM), resulting in a decrease in performance. In addition, it was found that a single EHC has a better compression ratio and reaction rate than a double EHC. The experimental results were compatible with the theoretical calculations within less than a 7% deviation. Finally, the conditions required to reach commercialization were evaluated using the theoretical model.
Estimation Method of Short-Circuit Current Contribution of Inverter-Based Resources for Symmetrical Faults
Authors: Vargas Murillo Cobe , Batista Oureste Elias , Yang Yongheng
Published: March 2023

This paper proposes a practical approach to estimate the symmetrical short-circuit current (SCC) levels in overcurrent protection devices (OCPDs) installed on radial feeders for any penetration level of inverter-based distributed energy resources (DERs). The proposed method restores the lost phase protection coordination by estimating SCC values and changing the TMS of OCPDs accordingly. The method is validated by comparing the results with simulations on the IEEE 34-Node Test Feeder using MATLAB/Simulink, which shows an average error of 1.5% and a maximum error of 3.0%. For a 100% penetration level, the SCC variation through OCPDs installed on the main fault trunk (MFT) exceeds ± 10%, leading to compromised phase protection coordination. The SCC flowing reversely through OCPDs on lateral branches and the fault on the MFT could cause improper tripping. Higher SCC levels are estimated and measured for fault impedances equal to zero. The phase protection is restored by changing the TMS of OCPDs using the estimated values. The study proposes two phase protection schemes to accommodate inverter-based DERs injecting 1.2 pu and 2.0 pu of SCC for a 100% penetration level. This study contributes to improving the protection coordination of distribution networks with high penetration levels of DERs. The findings have practical implications for distribution system operators and planners to maintain safe and reliable operation of distribution feeders.
Interpreting the Dynamic Nexus between Green Energy, Employment, Fossil Fuel Energy, and Human Development Index: A Panel Data Investigation
Authors: Azam Anam , Rafiq Muhammad , Shafique Muhammad , Yuan Jiahai
Published: March 2023

This study examines the dynamic connection between green energy, employment, fossil fuel energy, and human development index including additional variables such as education, life expectancy, and poverty in panel data of 30 developing countries from 1990–2017. Previous studies analyzed the total energy consumption on the human development index, whereas the differential effect of green and fossil fuel energy with employment and human development index has not been examined. The empirical exercise is based on the panel co-integration test, panel fully modified ordinary least squares, dynamic ordinary least squares, and vector error correction estimation approaches. The results reveal that all variables are co-integrated. The results of regression analysis indicate that green energy, education, life expectancy, and employment increase the human development index, but fossil fuel energy and poverty decrease the human development index by −0.016 and 0.023%. In addition, the vector error correction model designates that there is bidirectional causality between green energy consumption and the human development index. Therefore, for developing countries, the development and utilization of green energy sources (wind, solar, geothermal, etc.) are needed. Moreover, these countries should rely less on fossil fuel energy because it causes a decrease in the HDI.
Genome-Wide Identification, and In-Silico Expression Analysis of YABBY Gene Family in Response to Biotic and Abiotic Stresses in Potato (Solanum tuberosum)
Authors: Mazhar Hafiz Sabah-Ud-Din , Shafiq Muhammad , Ali Haider , Ashfaq Muhammad , Anwar Alia , Tabassum Javaria , Ali Qurban , Jilani Ghulam , Awais Muhammad , Sahu Ravi , Javed Muhammad Arshad
Published: March 2023

YABBY is among the specific transcription factor (TF) gene family in plants and plays an important role in the development of the leaves and floral organs. Its specific roles include lateral organ development, the establishment of dorsoventral polarity, and response to abiotic stress. Potato is an important crop worldwide and YABBY genes are not still identified and characterized in potato. So, little has been known about YABBY genes in potato until now. This study was carried out to perform genome-wide analysis, which will provide an in-depth analysis about the role of YABBY genes in potato. There have been seven StYAB genes identified, which are found to be located on seven different chromosomes. Through multiple sequence analyses, it has been predicted that the YABBY domain was present in all seven genes while the C2-C2 domain was found to be absent only in StYAB2. With the help of cis-element analysis, the involvement of StYAB genes in light, stress developmental, and hormonal responsiveness has been found. Furthermore, expression analysis from RNA-seq data of different potato organs indicated that all StYAB genes have a role in the vegetative growth of the potato plant. In addition to this, RNA-seq data also identified StYAB3, StYAB5, and StYAB7 genes showing expression during cadmium, and drought stress, while StYAB6 was highly expressed during a viral attack. Moreover, during the attack of Phytophthora infestans on a potato plant StYAB3, StYAB5, StYAB6, and StYAB7 showed high expression. This study provides significant knowledge about the StYAB gene structures and functions, which can later be used for gene cloning, and functional analysis; this information may be utilized by molecular biologists and plant breeders for the development of new potato lines.
SODD Promotes Lung Cancer Tumorigenesis by Activating the PDK1/AKT and RAF/MEK/ERK Signaling
Authors: Bao Fan , An Su , Yang Yang , Xu Tian-Rui
Published: March 2023

Background: The Bcl2-associated athanogene4 (BAG4/SODD) protein could be identified as a tumor marker for several malignancies and plays a major role in the occurrence, development, and drug resistance of tumors. However, the role of Silencer of death domains (SODD) in lung carcinogenesis is still elusive. Objective: To illuminate the effect of SODD on the proliferation, migration, invasion, and apoptosis of lung cancer cells and tumor growth in vivo and explore the corresponding mechanism. Methods: The expression of SODD in tumor and normal tissues was determined and compared via western blot. SODD gene knockout lung cancer cells (H1299 cells) were established through a CRISPR/Cas9 gene deleting system, and a transient SODD overexpression of H1299 cells was also constructed. Then, cell proliferation and invasion were assessed through colony formation and cell counting kit-8 assays, transwell migration assays, and wound healing assays. Cell drug sensitivity is also analyzed by Cell Counting Kit-8 assay. The flow cytometer was used to perform cell circle and apoptosis analysis. The interaction of SODD and RAF-1 was confirmed by co-immunoprecipitation, and the phosphorylated level of Phosphatidylinositol 3-kinase (PI3K), Serine/threonine-protein kinase (AKT), Rapidly accelerated fibrosarcoma (RAF)-1,and extracellular signal regulated kinase (ERK) in cells was examined by western blot to evaluate the activation of PI3K/PDK1/AKT and RAF/MEK/ERK pathways. In vivo, Xenograft tumor assay of SODD knockout H1299 cells was used to evaluate further the role of SODD on the proliferation of H1299 cells. Results: SODD binds to RAF-1 and is over-expressed in lung tissues, and promotes the proliferation, migration, invasion, and drug sensitivity of H1299 cells. The reduced cells in the S phase and increased cells arrested in the G2/M phase were found in SODD knockout H1299 cells, and more cells got apoptosis. The expression of 3-phosphoinositide-dependent protein kinase 1(PDK1) protein in SODD knockout H1299 cells decreases distinctively, and the phosphorylated level of AKT, RAF-1, and ERK-1 kinase in SODD knockout H1299 cells is also less than that in normal H1299 cells. In contrast, SODD overexpression significantly increases the phosphorylation of AKT. In vivo, SODD promotes the tumorigenicity of H1299 cells in nude mice. Conclusions: SODD is overexpressed in lung tissues and plays a considerable role in the development and progression of lung cancer by regulating the PI3K/PDK1/AKT and RAF/MEK/ERK pathways.
Social Inequities in Exposure to Traffic-Related Air and Noise Pollution at Public Schools in Texas
Authors: Chakraborty Jayajit , Aun Jacob J.
Published: March 2023

Although children are particularly vulnerable to the adverse impacts of vehicular pollution and spend significant portions of their time at school, previous studies have not examined or compared school-level social inequities in exposure to both traffic-related air and noise pollution in the same study area. We addressed this gap through a case study in Texas—the second-largest US state based on total population and number of children. Vehicular pollution exposure was measured using: (1) outdoor concentrations of nitrogen dioxide (NO2), a widely used proxy for traffic-related air pollution; and (2) road noise estimates from the US Department of Transportation’s National Transportation Noise Mapping Tool. These variables were linked to data on locations and sociodemographic characteristics of children enrolled in Texas public schools. We found children attending schools with the highest exposure to both NO2 and road noise (top 25%) were significantly more likely to be Black, Hispanic, and eligible for free/reduced lunches (socioeconomically deprived). Results from multivariable generalized estimating equations that control for spatial clustering and other relevant factors revealed that schools with greater NO2 exposure were significantly more likely to serve racial/ethnic minority and younger students, while schools with greater exposure to road noise were significantly more likely to serve socioeconomically deprived and older students. These findings underscore the urgent need to reduce both air pollution and noise exposure at school locations, especially in schools attended by higher proportions of socially disadvantaged children that are often additionally burdened with other challenges.