bluuebunny/crossref_metadata_2025 huggingface dataset:
Formal security analysis of lightweight authenticated key agreement protocol for IoT in cloud computing
Authors: Aly Ahmed H. , Ghalwash Atef , Nasr Mona M. , Abd-El Hafez Ahmed A.
Published: October 2021

The internet of things (IoT) and cloud computing are evolving technologies in the information technology field. Merging the pervasive IoT technology with cloud computing is an innovative solution for better analytics and decision-making. Deployed IoT devices offload different types of data to the cloud, while cloud computing converges the infrastructure, links up the servers, analyzes information obtained from the IoT devices, reinforces processing power, and offers huge storage capacity. However, this merging is prone to various cyber threats that affect the IoT-Cloud environment. Mutual authentication is considered as the forefront mechanism for cyber-attacks as the IoT-Cloud participants have to ensure the authenticity of each other and generate a session key for securing the exchanged traffic. While designing these mechanisms, the constrained nature of the IoT devices must be taken into consideration. We proposed a novel lightweight protocol (Light-AHAKA) for authenticating IoT-Cloud elements and establishing a key agreement for encrypting the exchanged sensitive data was proposed. In this paper, the formal verification of (Light-AHAKA) was presented to prove and verify the correctness of our proposed protocol to ensure that the protocol is free from design flaws before the deployment phase. The verification is performed based on two different approaches, the strand space model and the automated validation of internet security protocols and applications (AVISPA) tool.
Association of Blood Pressure, Its Treatment, and Treatment Efficacy With Volume of White Matter Hyperintensities in the Population-Based 1000BRAINS Study
Authors: Gronewold Janine , Jokisch Martha , Schramm Sara , Jockwitz Christiane , Miller Tatiana , Lehmann Nils , Moebus Susanne , Jöckel Karl-Heinz , Erbel Raimund , Caspers Svenja , Hermann Dirk M. ,   on behalf of the Heinz Nixdorf Recall Study Investigative Group
Published: October 2021

White matter hyperintensities (WMHs) of presumed vascular origin are a frequent finding in cerebral magnetic resonance imaging of older people. They are attributed to small vessel disease and involved in the pathogenesis of cognitive decline. Since vascular risk factors, especially arterial hypertension, predispose to small vessel disease, we analyzed the association of systolic blood pressure (SBP), diastolic blood pressure (DBP), and antihypertensive medications with WMH volume in 560 participants of the 1000BRAINS study, drawn from the population-based Heinz Nixdorf Recall study (65.2±7.5 years; 51.4% men). Further, we analyzed treatment efficacy using a classification of 6 BP treatment groups defined by antihypertensive medication and level of BP: (1) untreated BP <120/<80 mm Hg, (2) untreated SBP 120 to 139 or DBP 80 to 89 mm Hg, (3) untreated BP ≥140 or ≥90 mm Hg, (4) treated BP <120/<80 mm Hg, (5) treated SBP 120 to 139 or DBP 80 to 89 mm Hg, and (6) treated BP ≥140 or ≥90 mm Hg. Median WMH volume (Q1–Q3) was 4.6 (3.0–7.8) cm
3
; mean±SD of SBP and DBP was 128.6±17.4 and 76.1±9.8 mm Hg. In multivariable linear regression models, continuous SBP (β=0.63 cm
3
per 10 mm Hg [95% CI, 0.32–0.94]), DBP (0.64 cm
3
per 5 mmHg [95% CI, 0.37–0.91]), and antihypertensive treatment (1.23 cm
3
[95% CI, 0.14–2.23]) were significantly associated with WMH volume. Regarding treatment efficacy, only participants with hypertension despite treatment (treated BP ≥140 or ≥90 mm Hg) had significantly increased WMH volume (4.24 cm
3
[2.36–6.13]) compared with normotension without treatment (untreated BP <120/<80 mm Hg). Our results suggest that WMHs represent a marker of advanced hypertension pathology. Hence, early treatment should prevent WMHs.
Highly Selective PPARα (Peroxisome Proliferator‐Activated Receptor α) Agonist Pemafibrate Inhibits Stent Inflammation and Restenosis Assessed by Multimodality Molecular‐Microstructural Imaging
Authors: Iwata Hiroshi , Osborn Eric A. , Ughi Giovanni J. , Murakami Kentaro , Goettsch Claudia , Hutcheson Joshua D. , Mauskapf Adam , Mattson Peter C. , Libby Peter , Singh Sasha A. , Matamalas Joan , Aikawa Elena , Tearney Guillermo J. , Aikawa Masanori , Jaffer Farouc A.
Published: October 2021

BACKGROUND

New pharmacological approaches are needed to prevent stent restenosis. This study tested the hypothesis that pemafibrate, a novel clinical selective PPARα (peroxisome proliferator‐activated receptor α) agonist, suppresses coronary stent‐induced arterial inflammation and neointimal hyperplasia.

METHODS AND RESULTS

Yorkshire pigs randomly received either oral pemafibrate (30 mg/day; n=6) or control vehicle (n=7) for 7 days, followed by coronary arterial implantation of 3.5 × 12 mm bare metal stents (2–4 per animal; 44 stents total). On day 7, intracoronary molecular‐structural near‐infrared fluorescence and optical coherence tomography imaging was performed to assess the arterial inflammatory response, demonstrating that pemafibrate reduced stent‐induced inflammatory protease activity (near‐infrared fluorescence target‐to‐background ratio: pemafibrate, median [25th‐75th percentile]: 2.8 [2.5–3.3] versus control, 4.1 [3.3–4.3],
P
=0.02). At day 28, animals underwent repeat near‐infrared fluorescence–optical coherence tomography imaging and were euthanized, and coronary stent tissue molecular and histological analyses. Day 28 optical coherence tomography imaging showed that pemafibrate significantly reduced stent neointima volume (pemafibrate, 43.1 [33.7–54.1] mm
3
versus control, 54.2 [41.2–81.1] mm
3
;
P
=0.03). In addition, pemafibrate suppressed day 28 stent‐induced cellular inflammation and neointima expression of the inflammatory mediators TNF‐α (tumor necrosis factor‐α) and MMP‐9 (matrix metalloproteinase 9) and enhanced the smooth muscle differentiation markers calponin and smoothelin. In vitro assays indicated that the STAT3 (signal transducer and activator of transcription 3)–myocardin axes mediated the inhibitory effects of pemafibrate on smooth muscle cell proliferation.

CONCLUSIONS

Pemafibrate reduces preclinical coronary stent inflammation and neointimal hyperplasia following bare metal stent deployment. These results motivate further trials evaluating pemafibrate as a new strategy to prevent clinical stent restenosis.
Is non-contrast-enhanced magnetic resonance imaging cost-effective for screening of hepatocellular carcinoma?
Authors: Tan Genevieve Jingwen , Lee Chau Hung , Sun Yan , Tan Cher Heng
Published: October 2021

Introduction:

Ultrasonography (US) is the current standard of care for imaging surveillance in patients at risk of hepatocellular carcinoma (HCC). Magnetic resonance imaging (MRI) has been explored as an alternative, given the higher sensitivity of MRI, although this comes at a higher cost. We performed a cost-effective analysis comparing US and dual-sequence non-contrast-enhanced MRI (NCEMRI) for HCC surveillance in the local setting.

Methods:

Cost-effectiveness analysis of no surveillance, US surveillance and NCEMRI surveillance was performed using Markov modelling and microsimulation. At-risk patient cohort was simulated and followed up for 40 years to estimate the patients’ disease status, direct medical costs and effectiveness. Quality-adjusted life years (QALYs) and incremental cost-effectiveness ratio were calculated.

Results:

Exactly 482,000 patients with an average age of 40 years were simulated and followed up for 40 years. The average total costs and QALYs for the three scenarios — no surveillance, US surveillance and NCEMRI surveillance — were SGD 1,193/7.460 QALYs, SGD 8,099/11.195 QALYs and SGD 9,720/11.366 QALYs, respectively.

Conclusion:

Despite NCEMRI having a superior diagnostic accuracy, it is a less cost-effective strategy than US for HCC surveillance in the general at-risk population. Future local cost-effectiveness analyses should include stratifying surveillance methods with a variety of imaging techniques (US, NCEMRI, contrast-enhanced MRI) based on patients’ risk profiles.
Gems: From Bangkok to Lausanne. Belgian Jurist Gustave Rolin-Jaequemyns’ Letter to his French Colleague Ernest Lehr
Authors: Rousseau Antoine
Published: October 2021

The section ‘Gems’ consists of short articles which present sources that might be of interest to migration researcher. In this Gems: a letter sent from Bangkok on 23 August 1896 by Gustave Rolin-Jaequemyns to his French colleague Ernest Lehr. We show that this document enables us to highlight the international networks in which international law scholars were involved. It reveals the professional concerns and problems of the lawyer, but also the social reality of his daily life.
Pyrrosia sarthalensis, a new species of Polypodiaceae from Kathua District, Jammu and Kashmir, Western Himalaya, India
Authors: SINGH SUMIT , SNEHA  , SINGH BIKARMA
Published: October 2021

Pyrrosia sarthalensis, belonging to the family Polypodiaceae from the Bani Valley of Kathua district, Himalayan Jammu & Kashmir, India is described here as a new species. It shows restricted distributional range and so far, is only known from the Bani Valley, within the Himalayan centre of endemism. It is an epiphytic fern species having brownish sori, formed only on the upper half of the frond. Other diagnostic features include grooved rhizomes, rhizome scales, lamina size and structure, sori placement, size and structure, and spore characters. This new species is morphologically similar to P. flocculosa but differs in certain characters.
New species of Elaphoidella Chappuis, 1929 and Schizopera Sars, 1905 (Copepoda: Harpacticoida) from two caves in northeastern and southern Thailand
Authors: WATIROYRAM SANTI , SANOAMUANG LA-ORSRI , BRANCELJ ANTON
Published: October 2021

Two new copepod species from two caves in northeastern and southern Thailand are described. Elaphoidella isana sp. nov. and Schizopera paktaii sp. nov. were collected from the unsaturated zone of freshwater pools fed only by dripping water. They are closely related to E. intermedia Chappuis, 1931 and S. validior Sars, 1909, respectively. Elaphoidella isana sp. nov. can be distinguished from its closest relative by the armature of P4 and P5, and by the ornamentation of caudal rami. Schizopera paktaii sp. nov. differs from its relative S. validior in the armature of P1, P5 and caudal rami.
John Berkeley James Wells—An appreciation of his contributions to harpacticoid diversity and systematics
Authors: HUYS RONY
Published: October 2021

John Wells was born in Hammersmith, a district in west London, where he spent most of his childhood and teenage life. It was a surprise to find out only recently that he had received a scholarship to Latymer Upper School on King Street which is literally one block away from where I used to live when I started working at the Natural History Museum in the early 1990s. The site has a long history and can be traced to a charity school founded in 1624 by the English merchant Edward Latymer, a wealthy lawyer and puritan, who left part of his wealth for the clothing and education of “eight poore boyes” from Hammersmith.
Two new species of Tigriopus Norman, 1869 from Chonburi Province, Thailand (Crustacea: Copepoda: Harpacticidae)
Authors: CHULLASORN SUPAWADEE , KANGTIA PAWANA , SONG SUNG JOON , KHIM JONG SEONG
Published: October 2021

Two new species of the family Harpacticidae Dana, 1846, Tigriopus namsaiensis sp. nov. and T. wannapaensis sp. nov. were found in algal washings at Namsai and Wannapa beaches in Chonburi Province, Thailand. There are currently 14 known species in the genus, two of which, T. thailandensis Chullasorn, Ivanenko, Dahms, Kangtia & Yang, 2012 and T. sirindhornae Chullasorn, Dahms & Klangsin, 2013 were also discovered in Thailand. The genus Tigriopus Norman, 1869 has a worldwide distribution with nine species recorded from the Pacific Ocean (seven in the North Pacific and two in the South Pacific), four species from the Atlantic and adjacent seas, two species from the South Indian Ocean, and one species from Antarctica.

                Sexual dimorphism is expressed in the antennule, antenna, P2, P5, P6, and segmentation of the urosome. Tigriopus namsaiensis sp. nov. and T. wannapaensis sp. nov. are closely related to T. thailandensis and T. sirindhornae in sharing the following characters: fewer sensilla on the prosome; antennary exopod with one seta on exp-2; P4 exp-3 with two inner setae; female P5 baseoendopod with five setae; male P2 enp-2 with a seta fused to the segment; and male P5 exopod with five setae.

                Tigriopus namsaiensis sp. nov. closely resembles T. thailandensis, but the new species is characterized by four setae on the maxillulary coxa (three setae in T. thailandensis), the outermost seta on the female P6 is plumose (instead of the middle one), the lateral seta on the apical segment of the antennary exopod is discrete at the base (instead of fused to the segment), and the outermost seta of the male P5 exopod is plumose (instead of spinulose).

                Tigriopus wannapaensis sp. nov. is very closely related to T. sirindhornae, but the new species differs from the latter by the following characteristics: 2-segmented mandibular exopod (3-segmented in T. sirindhornae); five setae on the maxillulary coxa (instead of three); all setae on female P6 are plumose (instead of two plumose and one pinnate); the lateral seta on the apical segment of the antennary exopod is fused to the segment (instead of discrete at the base); and the outermost seta on the male P5 exopod is plumose (instead of spinulose).

                A dichotomous identification key to the 16 valid species of Tigriopus is provided.
Interannual Variability of Springtime Extreme Heat Events over the Southeastern Edge of the Tibetan Plateau: Role of A Spring-type Circum-global Teleconnection Pattern
Authors: Zhang Tuantuan , Jiang Xingwen , Chen Junwen , Yang Song , Deng Yi , Wei Wei , Hu Peng , Gao Peng
Published: October 2021

Due to the high mountains to the west and north of the plateau, and the control by westerly mean flow in spring, hot and dry conditions are often observed over the southeastern edge of the Tibetan Plateau (SETP), and hence favoring occurrences of extreme heat events there. Indeed, maximum centers and remarkable increasing trends of extreme heat (EH) days in spring are found over the region. Springtime EH events over the SETP also exhibit strong interannual variability and are closely linked to a spring-type circum-global teleconnection (SCGT) pattern, which is the second leading mode of 200-hPa meridional wind over the North Hemisphere in spring. This SCGT shows distinctive features from the traditional circum-global teleconnection patterns found in boreal summer and winter. It is revealed by a circum-globally navigated Rossby wave train along the mid-high latitudes, which splits to a north branch along the polar jet and a south branch along the subtropical jet over Eurasia after propagating through the North Atlantic. The two branches eventually reach the SETP, forming an anomalous anticyclonic circulation over the region. Hence, conditions in the SETP are controlled by significant anomalous subsidence and a clearer sky, resulting in below-normal rainfall and above-normal air temperature, in favor of more EH events in the region. The SETP EH events are also closely linked to the spring-type CGT-like pattern in April and May, but not in March. In addition, the influence of the foehn effect on the SETP EH is discussed.
“Gray Zone” Simulations Using a Three-Dimensional Planetary Boundary Layer Parameterization in the Weather Research and Forecasting Model
Authors: Juliano Timothy W. , Kosović Branko , Jiménez Pedro A. , Eghdami Masih , Haupt Sue Ellen , Martilli Alberto
Published: October 2021

Generating accurate weather forecasts of planetary boundary layer (PBL) properties is challenging in many geographical regions, oftentimes due to complex topography or horizontal variability in, for example, land characteristics. While recent advances in high-performance computing platforms have led to an increase in the spatial resolution of numerical weather prediction (NWP) models, the horizontal gridcell spacing (Δx) of many regional-scale NWP models currently fall within or are beginning to approach the gray zone (i.e., Δx ≈ 100–1000 m). At these gridcell spacings, three-dimensional (3D) effects are important, as the most energetic turbulent eddies are neither fully parameterized (as in traditional mesoscale simulations) nor fully resolved [as in traditional large-eddy simulations (LES)]. In light of this modeling challenge, we have implemented a 3D PBL parameterization for high-resolution mesoscale simulations using the Weather Research and Forecasting Model. The PBL scheme, which is based on the algebraic model developed by Mellor and Yamada, accounts for the 3D effects of turbulence by calculating explicitly the momentum, heat, and moisture flux divergences in addition to the turbulent kinetic energy. In this study, we present results from idealized simulations in the gray zone that illustrate the benefit of using a fully consistent turbulence closure framework under convective conditions. While the 3D PBL scheme reproduces the evolution of convective features more appropriately than the traditional 1D PBL scheme, we highlight the need to improve the turbulent length scale formulation.

Significance Statement

The spatial resolution of weather models continues to increase at a rapid rate in accordance with the enhancement of computing power. As a result, smaller-scale atmospheric features become more explicitly resolved. However, most numerical models still ignore the impact of horizontal weather variations on boundary layer flows, which becomes more important at these smaller spatial scales. To address this issue, we have implemented a new modeling approach, using fundamental principles, which accounts for horizontal variability. Our results show that including three-dimensional effects of turbulence is necessary to achieve realistic boundary layer characteristics. This novel technique may be useful for many applications including complex terrain flows, pollutant dispersion, and surface–atmosphere interaction studies.
The time Interval Between the End of Radiotherapy and Surgery Does Not Affect Outcomes in Rectal Cancer
Authors: Qwaider Yasmeen Z. , Sell Naomi M. , Stafford Caitlin E. , Kunitake Hiroko , Ricciardi Rocco , Bordeianou Liliana G. , Goldstone Robert N. , Cauley Christy E. , Berger David L.
Published: October 2021

Introduction

The ideal time interval between the completion of chemoradiotherapy and subsequent surgical resection of advanced stage rectal tumors is highly debated. Our aim is to study the effect of the time interval between the completion of chemoradiotherapy and surgical resection on postoperative and oncologic outcomes in rectal cancer.

Methods

Patients who underwent neoadjuvant chemoradiotherapy for resected locally advanced rectal tumors between 2004 and 2015 were included in this analysis. The time interval was calculated from the date of radiation completion to date of surgery. Patients were split into 2 groups based on the time interval (<8 weeks and >8 weeks). Postoperative outcomes (anastomotic leak, pathologic complete response (pCR), and readmission) and survival were assessed with multivariable logistic regression and Cox regression models while adjusting for relevant confounders.

Results

200 patients (62% male) underwent resection with a median time interval of 8 weeks from completion of radiotherapy. On multivariable logistic regression, there was no significant increase in odds between time interval to surgery and anastomotic leak (aOR = .8 [.27-2.7], P = .8), pCR (aOR = 1.2[.58-2.6] P = .6), or readmission (aOR = 1.02, 95% CI:0.49-2.24, P = .9). Time interval to surgery was not an independent prognostic factor for overall (HR = 1.04 CI = .4-2.65, P = .9) and disease-free survival (HR = 1.2 CI = .5-2.9, P = .6).

Conclusion

The time interval between neoadjuvant radiotherapy completion and surgical resection does not affect anastomotic leak rate, achievement of pCR, or overall and disease-free survival in patients with rectal cancer. Extended periods of time to surgical resection are relatively safe.
A comparison of experiences of care and expressed emotion among caregivers of young people with first-episode psychosis or borderline personality disorder features
Authors: Cotton Sue M , Betts Jennifer K , Eleftheriadis Dina , Filia Kate , Seigerman Mirra , Rayner Victoria K , McKechnie Ben , Hulbert Carol Anne , McCutcheon Louise , Jovev Martina , Bendall Sarah , Burke Emma , McNab Catharine , Mallawaarachchi Sumudu , Alvarez-Jimenez Mario , Chanen Andrew M , Gleeson John FM
Published: October 2021

Objective:

Caregivers of individuals with severe mental illness often experience significant negative experiences of care, which can be associated with higher levels of expressed emotion. Expressed emotion is potentially a modifiable target early in the course of illness, which might improve outcomes for caregivers and patients. However, expressed emotion and caregiver experiences in the early stages of disorders might be moderated by the type of severe mental illness. The aim was to determine whether experiences of the caregiver role and expressed emotion differ in caregivers of young people with first-episode psychosis versus young people with ‘first-presentation’ borderline personality disorder features.

Method:

Secondary analysis of baseline (pre-treatment) data from three clinical trials focused on improving caregiver outcomes for young people with first-episode psychosis and young people with borderline personality disorder features was conducted (ACTRN12616000968471, ACTRN12616000304437, ACTRN12618000616279). Caregivers completed self-report measures of experiences of the caregiver role and expressed emotion. Multivariate generalised linear models and moderation analyses were used to determine group differences.

Results:

Data were available for 265 caregivers. Higher levels of negative experiences and expressed emotion, and stronger correlations between negative experiences and expressed emotion domains, were found in caregivers of young people with borderline personality disorder than first-episode psychosis. Caregiver group (borderline personality disorder, first-episode psychosis) moderated the relationship between expressed emotion and caregiver experiences in the domains of need to provide backup and positive personal experiences.

Conclusion:

Caregivers of young people with borderline personality disorder experience higher levels of negative experiences related to their role and expressed emotion compared with caregivers of young people with first-episode psychosis. The mechanisms underpinning associations between caregiver experiences and expressed emotion differ between these two caregiver groups, indicating that different supports are needed. For borderline personality disorder caregivers, emotional over-involvement is associated with both negative and positive experiences, so a more detailed understanding of the nature of emotional over-involvement for each relationship is required to guide action.
Contestation and norm change in whale and elephant conservation: Non-use or sustainable use?
Authors: Peez Anton , Zimmermann Lisbeth
Published: October 2021

Elephants and whales took center stage in the environmental movements of the 1980s. As flagship species, they were the poster children of global initiatives: international ivory trading and commercial whaling were banned in the 1980s in the context of the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) and the International Whaling Commission (IWC), respectively. While the conservation of both species is contested, we observe a change of existing norms in one case but not in the other: A moratorium on commercial whaling remains in place. Meanwhile, a limited shift to sustainable use regarding ivory was passed in 1997/2000. We ask why norm change occurred in one case but not the other, given their similarities. We argue that the difference can be explained by the perceived legitimacy of the claims of norm challengers using arguments of “affectedness” and the breadth of issues covered by CITES. In contrast, other factors commonly discussed in norms research do not explain this puzzle: the relative power and strategies of norm advocates and challengers, and the degree of legalization. This shows the interplay of discursive aspects and concrete institutional opportunities for norm change, even in the face of otherwise inopportune conditions.
Satisfaction Levels, Communication Situations, and Difficulties Encountered by University Students Regarding Distance Education
Authors: Demirbilek Nesip
Published: October 2021

The aim of this study is to determine university students’ views on planning and conducting lectures in distance education, teaching materials, communication situations, and the difficulties they experience. A descriptive survey model, one of the quantitative research methods, was used in the study. Within the scope of the research, a distance education student satisfaction questionnaire developed based on the experiences of the researcher himself and an information form containing the personal information of the participants were used to collect data. The data collection tool was prepared over Google forms and delivered to 1,632 university students via What Sapp and mail. Since the study was prepared in descriptive and scanning type, descriptive statistics, t-test, and one-way analysis of variance (ANOVA) were used in the analysis of the data obtained. Descriptive statistics were used in the analysis of the first, third, fifth, and sixth questions; T-test and ANOVA were used in the analysis of the second and fourth questions. According to the findings of the research, it is seen that the anxiety of the students participating in the research is concentrated on the lectures and exams. Students with self-discipline overcome this process positively, while students without self-discipline often experience problems.
Introducing the Military Mutinies and Defections Database (MMDD), 1945–2017
Authors: Johnson Jaclyn
Published: October 2021

Military mutinies are critical to scholars’ collective understanding of civil–military relations. This article introduces a new dataset that systematically codes mutinies across all regions and conducts an exploratory analysis of these new data. The primary contribution made here is the introduction of a new dataset that provides scholars with a sample of mutinies across region, space, and time. The new Military Mutinies and Defections Database (MMDD) codes events of military indiscipline from 1945 to 2017. This dataset uses geocoding techniques that will enable scholars to explore the spatial patterns and diffusion associated with mutinies. The second contribution is the preliminary exploration of these new data. Of note, I demonstrate that over one-third of all mutinies are violent, 6% of mutinies are associated with civilian deaths, and anocracies are more likely to experience mutinies than democratic or autocratic counterparts. MMDD provides investigators with an exciting new tool to explore dimensions of military disloyalty.
The Alleged ‘Letter Allegedly from Us’: The Parallel Function of ὡς δι’ ἡμῶν in 2 Thessalonians 2.2
Authors: Brookins Timothy A.
Published: October 2021

The nearly unanimous consensus of modern scholarship is that 2 Thess. 2.2 refers to a letter either written or alleged to have been written by Paul, as captured in the most common rendering of the text, ‘a letter allegedly from/by us’. The thesis of this article is that the relevant phrase, ὡς δι’ ἡμῶν, does not serve to qualify ‘letter’ or the other two substantives that precede (‘a spirit’, ‘a word’), but that it identifies Paul (the implied author) as a medium of information alternative to the other three media, thus posing a contrast between teaching conveyed through Paul and teaching conveyed through not-Paul, in a manner analogous to Gal. 1.8. In addition to the greater probability of this interpretation grammatically, this interpretation is offered as resolving further difficulties concerning 1 Thess. 2.2, as well as its relationship to 2.15. Evidence is also offered that the consensus view does not find unanimous support among ancient interpreters.
Mothers’ Well-Being in Families and Family Structure: Examining Constellations of Stressors Across Life Domains
Authors: Recksiedler Claudia , Bernhardt Janine , Heintz-Martin Valerie
Published: October 2021

Identifying conditions under which parents thrive is a key concern of family research. Prior research often focused on mothers’ well-being in single life domains, yet it is more likely to be shaped by stressors that stem directly from the parenting role and related stressors emerging from spillover processes into other domains. We therefore examine how stressors concerning mothers’ subjective, relational, and financial well-being accumulate and combine within subgroups of mothers and whether the likelihood to belong to these multidimensional subgroups varies by family structure. Using representative German data ( N = 11,242), latent class analysis revealed four distinct subgroups of maternal well-being with varying exposure to financial, psychological, and relational stressors. Regression models showed that particularly single mothers were at risk to belong to the most vulnerable group with exposure to multiple stressors. Findings are discussed in light of persisting disparities among post-separation families despite demographic trends toward growing family diversity.
Wages of Skilled Migrant and Native Employees in Germany: New Light on an Old Issue
Authors: Brunow Stephan , Jost Oskar
Published: October 2021

The German Council of Economic Experts (GCEE) argues for a labor market-driven immigration of skilled migrants into Germany to overcome a decline in workforce due to demographic ageing. We pick up this current debate on skilled immigration by analyzing the migrant-native wage differential for skilled workers in Germany and consider various information on firms. Our results indicate that the wage gap is mainly explained by observable characteristics, especially labor market experience and firm characteristics. However, we find lower rewards for migrants’ labor market experience than for natives (flatter experience curves). Our results show that these differences in experience curves become negligible in the long run. Moreover, we reveal firms’ wage-setting policies: Firms evaluate a worker's education independent of migration backgrounds, as migrants possess the same productivity levels as their German counterparts in the same occupations and task levels. Due to Germany's heterogeneous immigration structure, we are able to compare the results for different migrant subgroups and, thus, derive valuable insights into the migrant-native wage structure with a wide reach beyond Germany. This article adds to current debates in various industrialized countries with demographic ageing patterns, as it focuses on an important group for domestic labor markets: skilled immigrants.
Straws and Bundles: Reviewing the Diversity Management Agenda at the Strategic Level
Authors: Das Roshni
Published: October 2021

Diversity management as a research domain has led to the emergence of a rather mixed bag of studies with conflicting findings. This review article seeks to synthesize these insights and then uncover the major theoretical perspectives that guide the crafting of the strategic human resource (HR) function specific to promoting diversity praxis in organizations. Eighty papers are reviewed using thematic review and content analytic methods. There are three sequential parts. First, we spend some time on how diversity has been conceptualized in academic literature and how it came to be linked to organizational performance. Second, we attempt to understand the definition of ‘diversity management’, review its implications for the strategic HR function and locate it with regard to functional HR practices. In the final part, we actually look at the black box contents, i.e., we review organizational HR activities that have been documented by scholars and the theories that have informed these activities at firm level and extra-firm level. Extensive research directions are suggested. A critique of praxis is offered, and how it is currently limiting academic inquiry is discussed.
Emerging adults’ preferred surnames: Reasons and social cognitive dispositions
Authors: Stafford Laura , Kline Susan L. , Hu Xiaodan
Published: October 2021

Surname practices in the U.S. are believed to reflect and reinforce the enduring patriarchal nature of U.S. society. Yet, some women and men reject patriarchal expectations. Calls for research accounting for such individual variations have been made. We examine the role that dispositional differences play in preferences for and reasoning about marital surnames in a sample of U.S. heterosexual women and men. With an online survey, we examined 799 heterosexual unmarried emerging adults’ (mean age = 19.9) preferences for their own and a future partner’s surname, reasons for their preferences, and associations with social cognitive dispositions relevant to self- and other-orientations: narcissism and perspective-taking. The findings suggest greater flexibility about women’s surname preferences than previously reported. Approximately one-third of men and women were open to nontraditional options. Reasons for preferences included heritage, tradition, masculinity norms, conceptions of marriage and family, identity, family pressures, and practical reasons. After controlling for age, relational status, traditionalism, autonomy, and career aspirations, lower perspective-taking was predictive of women’s preferences for both partners to retain their birth names, whereas greater narcissism was associated with women’s preferences to retain their birth name. Greater narcissism was associated with men’s desires for both partners to use his name. Taken together, the addition of individual difference dispositions provides greater insight into surname preferences and reasons for those preferences beyond gender masculinity norms.
Risk factors of contrast extravasation and subsequent hemorrhagic transformation after thrombectomy
Authors: Liu Keqin , Jiang Lin , Zhao Yuqi , Xia Wenqing , Ruan Jie , Huang Huan , Niu Guozhong , Yan Shenqiang , Yin Congguo
Published: October 2021

Objective

The risk factors associated with iodine contrast extravasation immediately after endovascular thrombectomy (EVT) and subsequent hemorrhagic transformation within 24 hours remain unclear.

Methods

Mixed images, iodine overlay maps, and virtual non-contrast images were reconstructed from 106 consecutive acute ischemic stroke patients who underwent dual energy computed tomography immediately and 24 hours after EVT. Multivariate analyses of clinical and radiological data were performed to explore independent predictors of iodine contrast extravasation and hemorrhagic transformation.

Results

Sixty-eight (64.2%) patients exhibited pure iodine contrast extravasation after EVT; 30.9% developed hemorrhagic transformation within 24 hours after EVT. The number of stent retriever passes was independently associated with both iodine contrast extravasation (odds ratio 1.608; 95% confidence interval (CI) 1.047–2.469) and subsequent hemorrhagic transformation (odds ratio 1.477; 95% CI 1.003–2.175). Patients with more than two stent retriever passes were more likely to exhibit iodine contrast extravasation (sensitivity = 68.2%, specificity = 81.5%), while those with more than three stent retriever passes more often exhibited hemorrhage after iodine contrast extravasation (sensitivity = 64.6%, specificity = 87.2%).

Conclusions

The number of stent retriever passes was an independent predictor for both iodine contrast extravasation and subsequent hemorrhagic transformation.
Securing Transplanted Meniscal Allografts Using Bone Plugs Results in Lower Risks of Graft Failure and Reoperations: A Meta-analysis
Authors: Ow Zachariah Gene Wing , Cheong Chin Kai , Hai Hao Han , Ng Cheng Han , Wang Dean , Krych Aaron J. , Saris Daniel B.F. , Wong Keng Lin , Lin Heng An
Published: October 2021

Background:

Meniscal allograft transplant (MAT) is an important treatment option for young patients with deficient menisci; however, there is a lack of consensus on the optimal method of allograft fixation.

Hypothesis:

The various methods of MAT fixation have measurable and significant differences in outcomes.

Study Design:

Meta-analysis; Level of evidence, 4.

Methods:

A single-arm meta-analysis of studies reporting graft failure, reoperations, and other clinical outcomes after MAT was performed. Studies were stratified by suture-only, bone plug, and bone bridge fixation methods. Proportionate rates of failure and reoperation for each fixation technique were pooled with a mixed-effects model, after which reconstruction of relative risks with confidence intervals was performed using the Katz logarithmic method.

Results:

A total of 2604 patients underwent MAT. Weighted mean follow-up was 4.3 years (95% CI, 3.2-5.6 years). During this follow-up period, graft failure rates were 6.2% (95% CI, 3.2%-11.6%) for bone plug fixation, 6.9% (95% CI, 4.5%-10.3%) for suture-only fixation, and 9.3% (95% CI, 6.2%-13.9%) for bone bridge fixation. Transplanted menisci secured using bone plugs displayed a lower risk of failure compared with menisci secured via bone bridges (RR = 0.97; 95% CI, 0.94-0.99; P = .02). Risks of failure were not significantly different when comparing suture fixation to bone bridge (RR = 1.02; 95% CI, 0.99-1.06; P = .12) and bone plugs (RR = 0.99; 95% CI, 0.96-1.02; P = .64). Allografts secured using bone plugs were at a lower risk of requiring reoperations compared with those secured using sutures (RR = 0.91; 95% CI, 0.87-0.95; P < .001), whereas allografts secured using bone bridges had a higher risk of reoperation when compared with those secured using either sutures (RR = 1.28; 95% CI, 1.19-1.38; P < .001) or bone plugs (RR = 1.41; 95% CI, 1.32-1.51; P < .001). Improvements in Lysholm and International Knee Documentation Committee scores were comparable among the different groups.

Conclusion:

This meta-analysis demonstrates that bone plug fixation of transplanted meniscal allografts carries a lower risk of failure than the bone bridge method and has a lower risk of requiring subsequent operations than both suture-only and bone bridge methods of fixation. This suggests that the technique used in the fixation of a transplanted meniscal allograft is an important factor in the clinical outcomes of patients receiving MATs.
Religious Interaction in Early Medieval Kamarupa: An Insight into the Kalikapurana
Authors: Bhuyan Rashmi Rekha
Published: October 2021

Like all other world religions, Brahmanism and Buddhism, the two prominent religious traditions of India, have histories of development and transformations since their inception. Depending on the socio-economic and political scenario, religions are subject to change, often in their basic beliefs and rituals, and at a certain point of time, the interaction between diverse religious traditions also becomes inevitable. Although opponent by nature in their early philosophies, Buddhism and Brahmanism got entwined at a certain phase of history, when many Buddhist deities and rituals were accommodated within the purview of Brahmanism and vice-versa. In the history of Brahmanical tradition, this interaction is traceable in the narratives of Puranic texts composed during the first millennium years of the Christian Era (ce). For the present study, one such Puranic text: the Kalikapurana, composed in Kamarupa (early Assam) during the early-medieval period, has been taken into account to understand the process of interaction between Brahmanism and Buddhism in the historical context of early Assam. Being primarily Brahmanical religious texts, the Puranas contain traces of Buddhism only in ‘covert’ form: in the form of myth. Focussing on some myths narrated in the Kalikapurana, the present study will discuss the existence of Buddhism in the early-Brahmaputra valley prior to the coming of Brahmanism. It will help us to understand the strategies adopted by the immigrant Brahmins to accommodate the prevailing traits under the purview of Brahmanical Hinduism.
Adsorption and reduction of carcinogenic organics by ordered semi-crystalline poly-m-chloroaniline
Authors: Gupta Pankaj , Singh Nakshatra Bahadur , Sahni Mohit
Published: October 2021

Poly-m-chloroaniline has been synthesized by chemical oxidative polymerization of m-chloroaniline and confirmed by spectroscopic studies. Powder X-ray diffraction and FESEM studies confirmed ordered arrangement in poly-m-chloroaniline. The peak at lower angle such as 7.09° having d spacing of 12.53 Å shows ordered structure of PmClA which was further confirmed by layered morphology in the FESEM images. FTIR spectra confirm the stretching and vibration mode of polymeric m-chloroaniline ring. BET surface area and pore diameter of PmClA were found to be 121 m2/g and 15.184 nm. Poly-m-chloroaniline was found to have better adsorption capacity toward anionic dyes over cationic dyes. The anionic dye (IC and EY) was 98 and 99% removed in just 25 min, whereas the cationic dye (MG and Rh6G) was 87 and 83% removed in 30 min. Langmuir adsorption isotherm model and pseudo second-order kinetic equation fitted the data best. Mechanism of adsorption has also been proposed. This is suggested that polymeric materials can be used for purification of water. The reduction of aromatic nitro compounds to amino compounds using organocatalyst has been done for the first time.
Facilitating primary care non-antiretroviral drug prescribing in people living with HIV: The ‘THINK ARV’ initiative
Authors: Knox Chloe , Leak Date Heather , Lim Su S , Shaw Mark , Flynn Brian , Kendall Lucy , Vera Jaime
Published: October 2021

Objectives: Older people living with HIV (PLWH) have higher rates of multimorbidity, polypharmacy and an associated increased risk of potential drug–drug interactions (DDIs). We describe the development, implementation and evaluation of an intervention to increase community prescribers’ access to specialist prescribing advice. Methods: Phase One: a survey evaluating General Practitioners’ (GPs’) knowledge of, and confidence detecting DDIs affecting PLWH, was circulated to eight General Practices in one UK city. Phase Two: co-production was used to develop the THINK ARV intervention for prescribers in city-wide General Practices: a dedicated mobile phone and e-mail advice service staffed by HIV specialist pharmacists. Queries were audited for 6 months pre- and post-intervention. A user-satisfaction survey was emailed to enquirers. Results: Phase One: 42 GPs responded, of whom 62% requested further support identifying DDIs among PLWH. Phase Two: the number of queries received increased from 25 (6 months before ‘THINK ARV’ launch) to 63 in the following 6 months (152% increase). 94% of the queries were specifically about DDIs. Conclusions: Increasing community prescribers’ access to specialist telephone and e-mail advice resulted in increased awareness and detection of DDIs. Similar interventions could be embedded within different healthcare settings to optimise medicines and avoid potential patient harm.
The asymptotic distribution of the Net Benefit estimator in presence of right-censoring
Authors: Ozenne Brice , Budtz-Jørgensen Esben , Péron Julien
Published: October 2021

The benefit–risk balance is a critical information when evaluating a new treatment. The Net Benefit has been proposed as a metric for the benefit–risk assessment, and applied in oncology to simultaneously consider gains in survival and possible side effects of chemotherapies. With complete data, one can construct a U-statistic estimator for the Net Benefit and obtain its asymptotic distribution using standard results of the U-statistic theory. However, real data is often subject to right-censoring, e.g. patient drop-out in clinical trials. It is then possible to estimate the Net Benefit using a modified U-statistic, which involves the survival time. The latter can be seen as a nuisance parameter affecting the asymptotic distribution of the Net Benefit estimator. We present here how existing asymptotic results on U-statistics can be applied to estimate the distribution of the net benefit estimator, and assess their validity in finite samples. The methodology generalizes to other statistics obtained using generalized pairwise comparisons, such as the win ratio. It is implemented in the R package BuyseTest (version 2.3.0 and later) available on Comprehensive R Archive Network.
Conditional copula models for correlated survival endpoints: Individual patient data meta-analysis of randomized controlled trials
Authors: Emura Takeshi , Sofeu Casimir Ledoux , Rondeau Virginie
Published: October 2021

Correlations among survival endpoints are important for exploring surrogate endpoints of the true endpoint. With a valid surrogate endpoint tightly correlated with the true endpoint, the efficacy of a new drug/treatment can be measurable on it. However, the existing methods for measuring correlation between two endpoints impose an invalid assumption: correlation structure is constant across different treatment arms. In this article, we reconsider the definition of Kendall's concordance measure (tau) in the context of individual patient data meta-analyses of randomized controlled trials. According to our new definition of Kendall's tau, its value depends on the treatment arms. We then suggest extending the existing copula (and frailty) models so that their Kendall's tau can vary across treatment arms. Our newly proposed model, a joint frailty-conditional copula model, is the implementation of the new definition of Kendall's tau in meta-analyses. In order to facilitate our approach, we develop an original R function condCox.reg(.) and make it available in the R package joint.Cox ( https://CRAN.R-project.org/package=joint.Cox ). We apply the proposed method to a gastric cancer dataset (3288 patients in 14 randomized trials from the GASTRIC group). This data analysis concludes that Kendall's tau has different values between the surgical treatment arm and the adjuvant chemotherapy arm ( p-value<0.001), whereas disease-free survival remains a valid surrogate at individual level for overall survival in these trials.
Children’s conceptions of coronavirus
Authors: Bonoti Fotini , Christidou Vasilia , Papadopoulou Penelope
Published: October 2021

The present study aimed to examine children’s conceptions of coronavirus as denoted in their verbal descriptions and drawings and whether these vary as a function of children’s age and the mode of expression. Data were collected in Greece during spring 2020 and 344 children aged 4 to 10 years were first asked to verbally describe coronavirus and then to produce a drawing of it. Content analysis of data revealed the following main themes: (a) Coronavirus, (b) Medical, (c) Psychological, and (d) Social. Results showed that children from an early age present a remarkable level of understanding of coronavirus and the COVID-19 disease as a multidimensional construct, which can be designated not only through characteristics of the Sars-Cov-2 but also through its medical, social, and psychological consequences on people’s lives. Moreover, children were found to emphasize different aspects of this construct depending on their age and the mode of expression.