bluuebunny/crossref_metadata_2025 huggingface dataset:
Research Trends in Immune Checkpoint Blockade for Melanoma: Visualization and Bibliometric Analysis (Preprint)
Authors: Xu Yantao , Jiang Zixi , Kuang Xinwei , Chen Xiang , Liu Hong
Published: August 2021

BACKGROUND

Melanoma is one of the most life-threatening skin cancers; immune checkpoint blockade is widely used in the treatment of melanoma because of its remarkable efficacy.

OBJECTIVE

This study aimed to conduct a comprehensive bibliometric analysis of research conducted in recent decades on immune checkpoint blockade for melanoma, while exploring research trends and public interest in this topic.

METHODS

We summarized the articles in the Web of Science Core Collection on immune checkpoint blockade for melanoma in each year from 1999 to 2020. The R package bibliometrix was used for data extraction and visualization of the distribution of publication year and the top 10 core authors. Keyword citation burst analysis and cocitation networks were calculated with CiteSpace. A Gunn online world map was used to evaluate distribution by country and region. Ranking was performed using the Standard Competition Ranking method. Coauthorship analysis and co-occurrence were analyzed and visualized with VOSviewer.

RESULTS

After removing duplicates, a total of 9169 publications were included. The distribution of publications by year showed that the number of publications rose sharply from 2015 onwards and either reached a peak in 2020 or has yet to reach a peak. The geographical distribution indicated that there was a large gap between the number of publications in the United States and other countries. The coauthorship analysis showed that the 149 top institutions were grouped into 8 clusters, each covering approximately a single country, suggesting that international cooperation among institutions should be strengthened. The core author extraction revealed changes in the most prolific authors. The keyword analysis revealed clustering and top citation bursts. The cocitation analysis of references from 2010 to 2020 revealed the number of citations and the centrality of the top articles.

CONCLUSIONS

This study revealed trends in research and public interest in immune checkpoint blockade for melanoma. Our findings suggest that the field is growing rapidly, has several core authors, and that the United States is taking the lead position. Moreover, cooperation between countries should be strengthened, and future research hot spots might focus on deeper exploration of drug mechanisms, prediction of treatment efficacy, prediction of adverse events, and new modes of administration, such as combination therapy, which may pave the way for further research.
ONLINE LEARNING INTERACTION OF MATHEMATICS TEACHER IN JUNIOR HIGH SCHOOL: A SURVEY IN THE COVID-19 PANDEMIC
Authors: Ahmad Ahmad , Mohamed Zulkifley , Setyaningsih Eka , Sugihandardji Chumaedi
Published: August 2021

This study aims to determine the online learning interactions carried out by junior high school teachers in the classroom during the COVID-19 pandemic. The quantitative using survey was used as a research methodology. 141 Mathematic Teachers was selected as the subject of this research. A questionnaire of classroom interaction practice in an online class was used as a data collection technique. The result found that mathematic teachers’ interaction activity in online courses has a different level. The interaction process that mathematic teachers use is in preparing the students to join an online course and leading the discussion with the mean of 4.2 and 4.3. In contrast, the lowest interaction happens in interaction in giving feedback and interaction in closing activity with an average of 2.5. the research also found that 78.70% of mathematic teachers always provide direction to the students in starting the online class. 40.30% of them never ask students to correct incorrect assignments during online learning.
Editorial: Insights into the future blended learning and corporate governance research in a COVID-19 world
Authors: Helfaya Akrum
Published: August 2021

We are pleased to share with you the first issue (volume 5, issue 1) of the journal Corporate Governance and Organisational Behaviour Review introduced in 2021. We hope that the readers of the journal will find this issue worth reading.
Global analysis of heme proteins elucidates the correlation between heme distortion and heme-binding pocket
Authors: Kondo Hiroko , Fujii Masanori , Tanioka Takuma , Kanematsu Yusuke , Yoshida Takashi , Takano Yu
Published: August 2021

Heme proteins play diverse and important biological roles, from electron
transfer and chemical catalysis, to oxygen transport and/or storage.
Although the distortion of heme porphyrin correlates with the physical
properties of heme, such as the redox potential and oxygen affinity, the
relationship between heme distortion and the heme protein environment is
unclear. We here tested the hypothesis that the protein environment of
the heme-binding pocket determines heme distortion (conformation). We
analyzed the correlations between the amino acid composition of the
heme-binding pocket and the magnitude of heme distortion along 12
vibrational modes by using machine learning. A correlation was detected
in the three lowest-vibrational modes. Analysis of heme distortions in
nearly the same environments of the heme-binding pocket supported this
notion. Our analyses indicate that the heme-binding pocket environment
is a major factor impacting the distortion of heme porphyrin along the
three lowest-vibrational modes. In addition, statistical analysis of the
distortion of heme porphyrin revealed that the peaks of distributions of
the ruffling and breathing distortions are shifted from 0 (the
equilibrium structure). Both the ruffling and breathing distortions are
correlated with the redox potential of heme, so that heme molecules with
these distortions have a lower redox potential than planar molecules.
These findings explain the structure–function relationship of heme and
can inform protein function engineering.
Impacting Neonatal Patient Care: Reducing Needle Sticks, with an Extended Dwell Catheter
Authors: Daly Tara M. , Girgenti Constance
Published: August 2021

Highlights

Background: The use and efficacy of extended dwell peripheral intravenous catheters (EPIVs) has been extensively described at scientific conferences and in recent literature. The ramifications of repeated needle sticks include damage to vessels and ultimately the need for more invasive and costly access devices, which clearly support the need for reliable forms of vascular access.

Methods: This quality improvement project spanned 4 years, 2017 through 2020, and included 128 patients who required a peripherally inserted catheter as their primary or secondary access site for a prescribed therapy. The EPIV utilized was a 4-cm, 22-gauge catheter made of thermosensitive polyurethane inserted using the Seldinger technique.

Results: Over the course of 4 years, 128 patients received an EPIV for 2 or more days, totaling 849 days of therapy. Total insertion attempts were 174 or an average of 1.4 per patient. An estimated number of short PIVs needed for 849 days would have been 404 with 1011 attempts. Resultant savings with EPIV are estimated to be $30,686.

Conclusions: Reducing the number of patient peripheral intravenous attempts while extending the dwell time results in less patient trauma, reliable longer-term access, reduced infection risk, reduced supply usage, and savings in terms of nursing time. The ultimate result for preterm newborns is more efficient delivery of care with less cost.
VDR/Atg3 Axis Regulates Slit Diaphragm to Tight Junction Transition via p62-Mediated Autophagy Pathway in Diabetic Nephropathy
Authors: Wang Bin , Qian Jing-yi , Tang Tao-tao , Lin Li-lu , Yu Nan , Guo Hong-lei , Ni Wei-jie , Lv Ling-Li , Wen Yi , Li Zuo-Lin , Wu Min , Cao Jing-Yuan , Liu Bi-Cheng
Published: August 2021

Foot process effacement is an important feature of early diabetic nephropathy (DN), which is closely related to the development of albuminuria. Under certain nephrotic conditions, the integrity and function of the glomerular slit diaphragm (SD) structure were impaired and replaced by the tight junction (TJ) structure, resulting in so-called SD-TJ transition, which could partially explain the effacement of foot processes at the molecular level. However, the mechanism underlying the SD-TJ transition has not been described in DN. Here, we demonstrated that impaired autophagic flux blocked p62-mediated degradation of ZO-1 (TJ protein) and promoted podocytes injury via activation of caspase3 and caspase8. Interestingly, the expression of VDR in podocytes was decreased under diabetes conditions, which impaired autophagic flux through downregulating Atg3. Of note, we also found that VDR abundance was negatively associated with impaired autophagic flux and SD-TJ transition in the glomeruli from human renal biopsy samples with DN. Furthermore, VDR activation improved autophagic flux and attenuated SD-TJ transition in the glomeruli of diabetic animal models. In conclusion, our data provided the novel insight that VDR/Atg3 axis deficiency resulted in SD-TJ transition and foot processes effacement via blocking the p62-mediated autophagy pathway in DN.
On total preservation of global solvability for a goursat problem associated with a controlled semilinear pseudoparabolic equation
Authors: Чернов А.В.
Published: August 2021

Исследуется задача Гурса для одного управляемого полулинейного уравнения четвертого порядка псевдопараболического типа, имеющего различные приложения. При сделанных предположениях доказывается тотальное (по всему множеству допустимых управлений) сохранение глобальной разрешимости указанной задачи.
The Effect of Infrapatellar Fat Pad Resection in Total Knee Replacement on Patella Tendon Length and Functional Outcomes after Five Years
Authors: M Sheldon
Published: August 2021

Background : It remains unclear whether infrapatellar fat pad (IPFP) excision leads to patella tendon shortening. Shortening of the tendon alters the biomechanics of the knee and can be problematic however current literature is divided regarding the effect of IPFP resect ion on patella length and functional outcomes following total knee replacement. Methods : Our aim was to identify any functional and radiographic differences incurred with IPFP resection. We conducted a retrospective study comparing resection and preservation of the infrapatellar fat pad between 2007 - 2009 using the Stryker Triathlon or Duracon implants between two independent consultant surgeons. 168 consecutive patients were recruited. Baseline demographics were similar between resection and preservation groups with a mean age of 68.5 (70 vs 67, p=0.17), BMI 31.71 (31.02 vs 32.4, p=0.84) and pa tella resurfacing 23.5 (24 vs 23, p=0.29). Results : Comparisons between the resection and preservation groups for the Insall - Salvati, Modified Insall - Salvati, Caton - deschamps and Blackburne - peel ratios preoperatively, at one year and five years postoperat ively did not demonstrate any statistically significant differences. Knee society scores (KSS) preoperatively (45.36 vs 40.5, p=0.31) and at five years postoperatively (90.49 vs 85.31, p=0.2) were not statistically different. Similarly anterior knee pain s cores (AKPS) demonstrated no statistical significance between groups preoperatively (50.6 vs 42.8, p=0.3) and at five years post operatively (69.4 vs 62.0, p=0.88). Conclusion : There is no statistical difference in radiological measures or functional score s (AKPS &KSS) at one or five years post - operatively between resection or preservation of the infrapatellar fat pad following total knee arthroplasty for primary osteoarthritis.
Effectiveness of Bacteriophages in the Era of Antibiotic Resistance
Authors: P Sankar
Published: August 2021

The prognosis of many diseases in the present circumstances is often dubious or uncertain. The reason for the present - day state is the consequences of reckless role of human mankind towards nature and irresponsible use antibiotics since when the antibiotics were discovered. The health of the human beings and livestock in the near future remains obscure If the same situation prevails. Hence, the decline in the effectiveness of antibiotics warrants the exploration of novel strategies and elements to combat the emerging antimicrobial resistance globally. Bacteriophages are one such alternate for antibiotics which can be commendably used in various fields like therapeutics, bio fe rmentation, food processing etc.
Effect of Sargassum wightii on Growth, Carcass and Serum Qualities of Broiler Chickens
Authors: K Athis Kumar
Published: August 2021

The basic feed supplemented with Sargassum powder (1%, 2%, 3% and 4%) provided more amount of essential amino acids, long chain fatty acids and minerals necessary for the growth of poultry than the basic feed. The growth promoting ability of Sargassum increased from 1% to 2% and then there was ste ady state, which is reflected in the weight gain, feed intake, feed conversion rate, carcass qualities and serum parameters of poultry. Sargassum powder had increased the growth to gain about 1265g more weight compared to the control and the supplementing effect was the maximum at 2% Sargassum powder. The feed intake per bird increased from 4647g at 1% Sargassum powder to 4813g at 4% Sargassum powder while it was 3042g in the control group. The feed conversion rate increased from 51.5 to 51.8 instead of 33. 9% in the control. Sargassum treatment increased the liver weight from 2.26% to 2.30%, the heart weight from 0.53% - 0,45%, the gizzard from 1.76% to 1.83%, the intestinal weight from 210.2 to 226.18%, the leg proportion from 3.77% to 4.57%, the breast weigh t from 28.26% to 30.27%, the thigh weight from 13.37% to 14.68%, the drumstick from 14.16% to 15.28% and the dressing from 70.32% to 81.12%. The maximum supplementary effect was noted at 1% and 2% of the Sargassum powder. Dietary treatment of broiler chick s with Sargassum powder significantly (P<0.05) decreased plasma cholesterol and globulin while increased the total serum protein, albumin, calcium, phosphorus and triglyceride compared to control. The 1% Sargassum gave 1.8 fold profits while 2%, 3% and 4% Sargassum powder gave 1.95 fold profit compared to the control. Meat qualities of chicks fed with 1% and 2% Sargassum were superior to the meat of poultry fed only with the basic feed.
Prevalence and Identification of Ixodide Ticks in Cattle in Lalo Assabi District, West Wollega Zone, West Oromia, Ethiopia
Authors: A Kebede
Published: August 2021

Ticks are important parasite of cattle that cause huge economic loss at private and national level. Therefore, the cross sectional study was conducted from October 2016 to June 2017 in Lalo Assabi district of West Wollega Zone . The aims of the stud y were to determine the prevalence of tick infestation and to identify their predilection site, possible risk factors and distribution in the rural and urban area of Lalo Assabi districts. Peasant Associations (PAs), sex, age, body conditions of animals an d ticks genera were major factors involved in the study. A systematic random sampling study design was followed to collect samples. From the total of 384 cattle, 265 ( 69%) cattle were found to be infested with tick. Out of five peasant associations examined, highest prevalence (80.4%) was recorded at Barko Daleti Peasant Associations. Highest prevalence ( 82% ) was observed in male than in female animals (59%). Relatively highest prevalence was recorded in adult animals (70.7%) as compared with young a nd old age animals. Amblyomma, Boophilus and Rhipicephalus were tick genera with infestation rate of 30.7 %, 23.2% and 15.1%, respectively. Animals with good body condition were relatively affected (74.1%). Different tick genera have different predilection sites. Amblyomma had strong preference for udder or scrotum (19.3%), Boophilus was highly prevalent on Udder or Scrotum and Genus Rhipicephalus was highly found attached to Dewlap (21.1%) . However, there was no significant variation on the prevalence of ti ck infestations (P>0.05). The study revealed that ticks are the most important ectoparasites and cause economic losses in the area. A nimal’s husbandry and management improvement is warranted to reduce the rate of tick’s infestation.
Fungal Diseases of Fish: A Review
Authors: Patel Ajay
Published: August 2021

Now a day, fishes are used for biomedical researches along with use as a food also. Chemical contaminants of marine environments are of momentous concern. Similar to other flora and fauna, fish can also be ill with various types of diseases. Freshwater fishes are an important protein source for people of many countries. Fish farming in various parts of the world has increased many folds in the last decade. Bacterial hemorrhagic septicemia, lernaeasis, saprolegniasis and anoxia are the most frequently occurring fish diseases in pond fishes. Fungal infections are among the most general diseases seen in temperate fish. Water moulds infections cause losses of freshwater fishes and their eggs in both natural and commercial fish farms. Although, infection as a result of microbial contamination does not frequently result in disease but ecological stress may upset the balance between the probable pathogens and their hosts. Prevention is, as always, the best medicine. Most infe ctions can be successfully treated if caught early.
Ebola Virus and its Public Health Significance: A Review
Authors: Y Nesradin
Published: August 2021

Ebola virus disease is a severe, often - fatal, zoonotic viral disease in humans and Nonhuman primates (NHP) like monkeys, gorillas and chimpanzees. Ebola is RNA virus that belongs to the family filoviridae, genus Ebola virus. The viruses (EBOV) are enveloped, non - segmented, negative - sense, single - stranded RNA viruses. Ebola virus disease (EVD) was first described in the Democratic Republic of Congo (DRC) in 1976. The exact origin, locations and natural reservoir of Ebola virus remain unclear. People can be exposed to Ebola virus from direct contact with the blood and/or secretions of an in fected person. Hunting and butchering of wildlife (great apes and fruit bats) has been identified in previous outbreaks as a potential source of infection. The onset of Ebola virus disease is sudden and early symptoms includes; fever and headache, followed by vomiting and diarrhea. Patients in the final stage of disease die in the clinical picture of massive bleeding, severe dehydration, hypovolemic shock and multi - organ failure. Ebola virus infections can be diagnosed by detecting antigens with an antigen capture ELISA and by detecting viral RNA with Reverse Transcriptase Polymerase Chain Reaction (RT - PCR). No specific treatment has been demonstrated yet to be safe and effective for Ebola virus. Standard treatment currently consists of supportive therapy, i ncluding maintenance of blood volume and electrolyte balance, as well as standard nursing care. Prevention and control is mainly based on appropriate precautions to break ways of transmission. Despite the fact that no detection of the virus had been discov ered in Ethiopia so far, it is in medium risk country because of most people travelling from West Africa to South Africa travels via these countries. But, there is lack of updated information on Ebola virus and its zoonotic importance. All the necessary pr ecautions should be made to prevent the virus from entering the country and thus Ethiopian Airlines has been informing passengers on ways to reduce risking exposure and preventing the spread of the disease for those traveling to and from affected countries.
West Nile Virus: Measures against Emergence in Malaysia
Authors: AR Yasmin
Published: August 2021

West Nile virus has a potential to emerge in new areas and cause large epidemics as was witnessed in the United States following its introduction in 1999. The virus is now a global public health threat, having been detected on every continent except Antarc tica. Once restricted to Africa, its expansion beyond its natural habitat is related to some viral, vectoral, anthropologic and environmental factors. The successful establishment and spread of the virus depend in part on viral adaptations, availability of competent hosts and mosquito vectors and suitable environmental conditions. A combination of measures can be applied to minimise the likelihood of a WN virus epidemic. Available vaccines are only for veterinary use, human vaccines are still in development . Vector control, animal vaccination, targeted surveillance and strong cooperation between relevant authorities are important in preventing a WN virus epidemic in Malaysia.
Canine Leishmaniosis: A Silent Burden in Southeast Asia and Elucidating Existing Knowledge Gap
Authors: PA Abdul Rani
Published: August 2021

Canine leishmaniosis is one of the most important canine vector - borne diseases (CVBD) caused by protozoan Leishmania sp . which pose zoonotic threat as some of its species are zoonotic. This parasitic disease is classified as Neglected Tropical Disease (NTD) and can be found in parts of the tropics, subtropics and southern Europe. A lot of studies had been carried out across the globe but lack in Southeast Asia, thus its epi zootiology is still poorly understood. This article is meant to create awareness of the existence of this zoonotic disease amongst veterinary personnel, scientific community and readers.
Therapeutic Prospective of Stem Cells in Veterinary Practice
Authors: HM Suranji Wijekoon
Published: August 2021

Therapeutic application of stem cell in veterinary medicine continues to develop rapidly both experimentally and clinically. Identification and isolation of multi - potential capability of stem cells from different sources of animal tissues and testing their efficacy to use in regenerative medicine are the novel trend in tissue engineering. Several animal models are being using for preclinical evaluation of stem cell applications in human and animal in areas such as spinal cord injury, cartilage defects, ligament defect and myocardial infarction. Today, numerous veterinary diseases are being treating with the administration of stem cells. However, these applicati ons have not been implemented well, to overcome the challenges faced by the clinicians. Further, with the limited data the therapeutic role of stem cells in regenerative medicine is not fully understood. This review will emphasize the application of stem c ell therapy in veterinary medicine offering a safe and clinically effective tool for the clinician to assist treatment of the animal.
Quantitative Detection of Aflatoxin M1, Ochratoxin and Zearalenone in Fresh Raw Milk o f Cow, Buffalo, Sheep and Goat by UPLC XEVO - TQ i n Dakahlia Governorate, Egypt
Authors: M Elalfy Mahmoud
Published: August 2021

Animals’ derived food as milk is highly nutritive food for human and substitute mother’s milk for children especially after 6 months. To better produce and maintain sa fe milk and milk product, Ultra Performance Liquid Chromatography XEVO - TQ (UPLC) used to monitor mycotoxins as aflatoxin, ochratoxin and zearalenone levels in fresh raw milk of dairy domestic animals. AFL - M1 was detected in all samples in cow, buffalo, she ep and goat milk with different concentration ranged from high, medium and very low with mean 906, 811.1, 1394.86 and 1183.68 ng/L respectively. According worldwide standard for aflatoxin M1 level in milk as EC and according US FDA Limit, all samples of raw milk exceed this limit up to 100ng /l while 50%, 80, 90 and 60% exceed US FDA Limit. Notably, the Egyptian raw milk is free from ochratoxin and zearalenone mycotoxin. Taken collectively , strict strategies should be taken to reduce level of aflatoxin in raw milk between producer and consumer and so reduce risk of adverse effect on health.
Jumping of Camelid Coronavirus in Bovines: A Report from Rural Area of Haryana, India
Authors: Prasad Minakshi
Published: August 2021

Bovine coronaviruses (BCoVs) are generally species specific, but cross species transmission has been demonstrated experimentally. Several examples have represented the infection of humans by coronavirus. Most of the coronaviruses are found in domestic as well as wild animals, and it is possible that they arose in human population though zoonotic transmission. In the present study, we evaluated presence of bovine corona virus (BCoV) in bovine fecal samples and reported the infection using RT - PCR assay. BCoV was detected using trans - membrane (M) gene specific RT - PCR with 523 bp amplicon size. A total three hundred thirteen (313) bovine fecal samples were collected for the present study. Out of 313 buffalo fecal samples, 31 buffalo were found infected with coronavirus by RT - PCR assay. The results suggest that RT - PCR is sensitive and specific method to detect BCoV, especially in subclinical cases. These results were further c onfirmed by sequencing of PCR products. The phylogenetic analysis showed that BCoV strains ABT/16/BF/Bocv183, ABT/BF/16/Bocv164 and ABT/BF/16/Bocv86 have close association with bovine strains from USA and Japan. However, ABT/BF/16/Bocv167 strain formed a s eparate clad along with camelid coronavirus strains and revealed the cross species transmission from camel to bovine. To the best of our knowledge this is the first report of interspecies transmission of coronavirus form camel to bovine.
Radiological Evaluation of Fractures Healing Processing Fixed by Food Grate Stainless Steel Rods in Rabbits
Authors: H Nazht Humam
Published: August 2021

This study was designed to follow up the radiological changes of the fracture healing process of the induced transverse femoral mid shift fracture in rabbits that fixed by food grate stainless steel rods (FGSR). Eight adult local breed rabbits were employed to induce complete transverse mid shift fracture in the femoral bone, under general anesthesia with highly aseptic technique. The fracture fragments fixed with FGSR, the study followed for more than two months by weekly radiographic examination, which revealed, the fracture healing occurs by secondary or indirect bone union, in which the new bone formation can be visible radiographically at the end of 2 nd week Post operati on (p. o.) around the fractures line which still visible, the callus formation increase in volume and density at the end of 3 rd week, at the end of 4 th weeks bony bridge formation and disappear of fracture line, at the end of the 6 th weeks radiological unio n occurs and the FGSR removed and remodeling phase started and continuous next week the conclusion the fracture healing processing of the induced fracture in the femoral bones in rabbits which fixed FGSR as internal fixation methods can be determined radio graphically.
Assessing the Effects of Substitution and Substituent Position on the Reactivity of Salicylideneaniline Ligands to Coordinate Transition Metal(II) Ions: a DFT Study
Authors:   Laboratory of Molecular Chemistry and Environment, University of Biskra, BP 145, 07000 Biskra, Algeria, Mohamed Sellami , Djamel Barkat ,   Laboratory of Molecular Chemistry and Environment, University of Biskra, BP 145, 07000 Biskra, Algeria, Eddine Hachani Salah ,   Applied Chemistry Laboratory, University of Biskra, BP 145, 07000 Biskra, Algeria
Published: August 2021

The present scientific contribution aims to investigate computationally the effects of substitution and substituent position on the reactivity of a series of salicylideneaniline derivatives ligands containing 13 molecules. Global reactivity parameters such as the EHOMO, ELUMO, gap energy, electronegativity, chemical hardness, chemical softness, electrophilicity index, and molecular electrostatic potential analysis (MESP) have been calculated at DFT/B3LYP/TZP level of theory and then well discussed to give valuable explanations for the effects of substitution and substituent position on the reactivity of the studied ligands.
Study on Chemistry of Oxidative Desulfurization Process of High Sulfur Straight-Run Oil Fraction
Authors:   Lviv Polytechnic National University 12 S. Bandery str., 79013 Lviv, Ukraine, Pyshyev Serhiy , Korchak Bohdan ,   Lviv Polytechnic National University 12, S. Bandery St., 79013 Lviv, Ukraine, Miroshnichenko Denis ,   National Technical University, Kharkiv Polytechnic Institute, 2 Kyrpychova St., Kharkiv 61002, Ukraine, Nyakuma Bemgba Bevan ,   Research Initiative for Sustainable Energy Technologies, Makurdi, Benue State, Nigeria
Published: August 2021

In the article the chemistry of the noncatalytic oxidative desulfurization process of distillate oil fractions is analyzed. The study involves the characteristics of high-sulfur straight-run diesel fraction of narrow composition (593–623 K) before and after oxidation by air at 453–493 K and a pressure of 3.0 MPa. The composition of sulfur compounds in the raw material fraction was determined. It is shown that straight-run fractions of raw materials may also contain sulfoxides, which are products of oxidation of organosulfur compounds and are formed during storage of petroleum products. On the basis of IR spectroscopic studies of raw materials, oxidized products and model mixtures, the transformation depth of fr. 593–623 K sulfur compounds, which are distributed in the form of sulfones and sulfoxides in solid and liquid oxidation products, and partially remain in the purified fuel, was analyzed in the above-mentioned process.
Production of Bitumen Modified with Low-Molecular Organic Compounds from Petroleum Residues. 2. Bitumen Modified with Maleic Anhydride
Authors:   Lviv Polytechnic National University 12 S. Bandery str., 79013 Lviv, Ukraine, Gunka Volodymyr , Prysiazhnyi Yuriy ,   Lviv Polytechnic National University 12, S. Bandery St., 79013 Lviv, Ukraine, Hrynchuk Yurii ,   Lviv Polytechnic National University 12, S. Bandery St., 79013 Lviv, Ukraine, Sidun Iurii ,   Lviv Polytechnic National University 12, S. Bandery St., 79013 Lviv, Ukraine, Demchuk Yuriy ,   Lviv Polytechnic National University, 12, Bandera St., 79013 Lviv, Ukraine, Shyshchak Olena ,   Lviv Polytechnic National University, 12, Bandera St., 79013 Lviv, Ukraine, Bratychak Michael ,   Lviv Polytechnic National University, 12, Bandera St., 79013 Lviv, Ukraine
Published: August 2021

The possibility of modification of BND 60/90 bitumen produced at JSC Ukrtatnafta (Kremenchuk, Ukraine) with maleic anhydride has been considered. The effect of maleic anhydride amount, process time and temperature on the operating characteristics of modified bitumen has been studied.
Analisis Kesulitan Guru Pembimbing dalam Menguasai Konsep dan Praksis Assesment
Authors: Maharani Citra Abriani , Rosra Muswardi , Yusmansyah Yusmansyah , Utaminingsih Diah
Published: August 2021

This research aimed to determine the level of difficulty of the Supervising Teacher in Mastering the Concept and Praxis of Assessment to Understand the Conditions, Needs, and Problems of the Counselee. This research used survey research methods with descriptive quantitative research. The population of the research was 160 guidance and counseling teachers who were taken by using proportional sampling techniques from each regional representative, so that 50 teachers of guidance and counseling were obtained. The data collection is collected through understanding tests. The data analysis is used descriptive quantitative analysis. The results of the study showed that the Level of Teacher Difficulties in Mastering the Concept and Praxis of Assessment to Understand the Conditions, Needs, and Problems of the counselees in the very low category with a percentage of 44%. This is supported by the results of the respondents' justification analysis that the level of understanding of the concepts and assessment praxis in guidance and counseling teachers in schools is in the moderate category with only 16%. Keywords: counselor competence, assessment, mastery of concept and prescriptive assessment, teacher guidance and counseling
Peningkatan Kemampuan Kognitif Melalui Bermain Eksperimen
Authors: Herminastiti Rini
Published: August 2021

This study aims to improve the cognitive abilities of early childhood aged 5-6 years through playing experiments in science at Nur Annisa Ciracas School, East Jakarta, the odd semester of the 2019/2020 school year. This research is a classroom action research. This research method is a classroom action research which refers to the model of Kemmis Taggart. This study consisted of II cycles where each cycle included 4 stages, namely planning, implementing, observing and reflecting. The research implementation time was 2 months, namely August and September with 12 students as research subjects, while the data were collected through observation, interview and observation. Based on the research results in cycle I and cycle II, there was an increase in cognitive abilities through playing science experiments. This is evidenced by the increase in the average value per class in cycle I = 60.06% and an increase of 20.14% in cycle II = 80.20% which has exceeded the 75% success criteria. This study concluded that playing science experiments can improve cognitive abilities in early childhood.
Pengaruh Diskusi Kelompok dalam Model Discovery Learning Terhadap Hasil Belajar IPA
Authors: Salsabila Viona , Jaya M. Thoha B. S. , Efendi Ujang
Published: August 2021

The problem in this research was the student�s result of IPA in the thematic learning at Jatimulyo Elementary School 3 are still low. The purpose of this study was to find out 1) the comparison of IPA learning outcomes in thematic learning using discovery learning models more effectively compared to those using conventional learning, and 2) the effect of group discussions in discovery learning models on IPA learning outcomes. The type of research used is experimental research with the research design is nonequivalent control group design. The population of this research were all fifth grade students of SDN 1 Jatimulyo, SDN 2 Jatimulyo, and SDN 3 Jatimulyo. The research sample was the fifth grade students of SDN 3 Jatimulyo. The sampling technique used multistage random sampling technique. Data collection techniques used observation and tests. Data analysis used simple linear regression test and t-test. Based on the results of hypothesis analysis was that1) the results of IPA learning in thematic learning that used the discovery learning model are more effective than those using conventional learning, and 2) the group discussion in the discovery learning model effected to the student�s IPA result in thematic learning.
Creating Efficiencies in the Extraction of Data From Randomized Trials: A Prospective Evaluation of a Machine Learning and Text Mining Tool
Authors: Gates Allison , Gates Michelle , Sim Shannon , Elliott Sarah A. , Pillay Jennifer , Hartling Lisa
Published: August 2021

Background. Machine learning tools that semi-automate data extraction may create efficiencies in systematic review production. We prospectively evaluated an online machine learning and text mining tool’s ability to (a) automatically extract data elements from randomized trials, and (b) save time compared with manual extraction and verification. Methods. For 75 randomized trials published in 2017, we manually extracted and verified data for 21 unique data elements. We uploaded the randomized trials to ExaCT, an online machine learning and text mining tool, and quantified performance by evaluating the tool’s ability to identify the reporting of data elements (reported or not reported), and the relevance of the extracted sentences, fragments, and overall solutions. For each randomized trial, we measured the time to complete manual extraction and verification, and to review and amend the data extracted by ExaCT (simulating semi-automated data extraction). We summarized the relevance of the extractions for each data element using counts and proportions, and calculated the median and interquartile range (IQR) across data elements. We calculated the median (IQR) time for manual and semiautomated data extraction, and overall time savings. Results. The tool identified the reporting (reported or not reported) of data elements with median (IQR) 91 percent (75% to 99%) accuracy. Performance was perfect for four data elements: eligibility criteria, enrolment end date, control arm, and primary outcome(s). Among the top five sentences for each data element at least one sentence was relevant in a median (IQR) 88 percent (83% to 99%) of cases. Performance was perfect for four data elements: funding number, registration number, enrolment start date, and route of administration. Among a median (IQR) 90 percent (86% to 96%) of relevant sentences, pertinent fragments had been highlighted by the system; exact matches were unreliable (median (IQR) 52 percent [32% to 73%]). A median 48 percent of solutions were fully correct, but performance varied greatly across data elements (IQR 21% to 71%). Using ExaCT to assist the first reviewer resulted in a modest time savings compared with manual extraction by a single reviewer (17.9 vs. 21.6 hours total extraction time across 75 randomized trials). Conclusions. Using ExaCT to assist with data extraction resulted in modest gains in efficiency compared with manual extraction. The tool was reliable for identifying the reporting of most data elements. The tool’s ability to identify at least one relevant sentence and highlight pertinent fragments was generally good, but changes to sentence selection and/or highlighting were often required.
The main trends in the graphic design development as a tool of visual communication in the information society
Authors: Udris-Borodavko Natalia , Bozhko Tatyana , Vezhbovska Liliana , Chuieva Oksana , Oliinyk Viktoriia , Hordiichuk Yaroslav
Published: August 2021

The aim of the article was to identify the main trends in the development of graphic design in the modern information society. This article uses qualitative and quantitative methods of analysis of graphic design development. Based on statistical analysis, the graphic design markets of Italy, Germany, Hungary and Poland for 2018 were estimated according to the European Design report (2018). Based on the indicators of ICT sector development, the state of the information society for the formation of potential trends in the development of graphic design has been identified. Indicators of skills shortages and skills shortages in the ICT sectors of the countries were taken from the OECD database (2021). The results show differences in the development of the ICT sector of countries and design markets.
Risky Choices
Authors: Rozas Gómez Claudia
Published: August 2021

Achievement data from New Zealand secondary schools suggest that students from lower socio-economic communities have fewer opportunities to engage with complex content in subject English. This article examines this phenomenon by drawing on Foucault’s notion of governmentality and considers how a context of simultaneously increased autonomy and surveillance may shape curriculum and assessment choices. To explore these ideas, I use interview data from ten secondary English teachers in the wider Auckland region. I complement Foucault’s (1982) explanation of governmentality with Ball, Maguire, and Braun’s (2012) notion of policy enactment to explore spaces of both compliance and resistance.
The importance of people and place
Authors: McFadyen Emma , Benade Leon
Published: August 2021

This ecofeminist-inspired research study, influenced by an ethic of care, engaged the participants in photo-elicitation and interviews. Ecofeminism originated as a theory and movement related to women and the environment (Estévez-Saá & Lorenzo-Modia, 2018), while an ethic of care stems from relational ethics that assumes human connectedness in context (Clement, 1996; Noddings, 2013). Thematic and visual narrative analysis of collected data supported the establishment of findings. The study aimed to contribute to the idea that a place-based approach can be taken to developing a holistic, meaningful and balanced local curriculum – one that privileges a ‘sense of place’ and the relationship between humans and their environments as co-habitors.
Third Worlds, Coolie and Coolitude: Unravelling the long arm of history
Authors: Pio Edwina , Moon Paul
Published: August 2021

Sugar dictated the fortunes of many countries in the British Empire in the nineteenth century.  With the abolition of slavery, thousands of indentured labour or coolies from the Indian subcontinent, filled the labour gap. The word coolie was derogatory, referring to a marginalized underclass, whereas the word coolitude evokes and acknowledges agency.  Our article revolves around the question: How does a historical lens evoke understandings of ethnic minorities (EM) at work in contemporary organisations? We illuminate a historical lens (the eternal present and linear progression, historical determinism and structuralism, and evoking the past), to provoke reflections on how on-going marginalisation of ethnic minorities at work, may be tethered to a coolie template. We weave conceptual understandings of history, indentured labour and EM in an interdisciplinary manner to evoke reflection by policy framers and managers on how the long arm of history may be implicated and unravelled. We suggest that such insights are necessary to highlight perceptions of coolitude as an alternative epistemology pertaining to EM at work
La sociologie pragmatique
Authors: Calderón-Vélez Milton Leonel
Published: August 2021

La propuesta epistemológica y metodológica de la sociológica pragmática es relativamente poco conocida en el contexto latinoamericano por lo que considero de importancia reseñar el texto "Sociología Pragmática" de Cyril Lemieux. Esto pese a que, en el estricto sentido del término, se trate más bien un manual (en francés) que declara y compendia los principios, conceptos, métodos, campos de investigación y debates relacionados al acercamiento pragmático.

Cyril Lemieux (2018). La sociologie pragmatique. Paris: La Découverte
A Comparative Study to Assess the Quality of Life and Stress among Orphan and Non-orphan Children in Selected Areas of Bagalkot
Authors:   Associate Professor, Dept. of Paediatric Nursing, BVVS Sajjalashree Institute of Nursing Sciences, Navanagar, Bagalkot, Karnataka, India, Sajjan Santosh B
Published: August 2021

Introduction: The word orphan comes from the Greek word ‘Orfanos’ and refers to a child permanently bereaved of or abandoned by his or her parents. Methods: A non-experimental descriptive comparative design has been adopted for the present study. The sample of the present study comprises orphan children residing in an orphanage and non-orphan children residing in selected areas of Bagalkot. The sample comprised 30 orphans and 30 non-orphans aged between 10 and 16 years. The data were collected by using self-report, structured closed-ended questionnaires for socio-demographic variables of children, self-administered WHO Quality of life BREF scale, and PSS stress scale. The data obtained were analysed with the help of descriptive and inferential statistics. Result: Findings related to the comparison between the level of stress among the orphan and non-orphan children revealed that majority of orphan children (76.66%) had about moderate stress, 23.33% of the orphan children had high stress, and none of the children had a low level of stress, whereas among non-orphan children, majority (90%) had moderate stress, 10% had low level stress, and none of them had high level stress. The findings related to the comparison of levels of quality of life among the orphan and non-orphan children reveal that a high percentage of orphan children (66.66%) had a moderate quality of life and some of them (33.33%) had a poor quality of life, whereas a high number of non-orphan children (66.66%) had a very good quality of life and some (33.33%) had a good quality of life. No significant association was found between the quality of life and stress scores with the socio-demographic variables of orphan and non-orphan children. Conclusion: The study concluded that orphan children need to improve their quality of life and decrease their level of stress.
SELF-EFFICACY, ORGANIZATIONAL COMMITMENT,
AND EMPLOYEE PERFORMANCE – FROM PUBLIC OFFICE
Authors: Maria Siti , Lestari Digra , Rochaida Eny , Darma Dio Caisar , Rahmawati Heni Rahayu
Published: August 2021

Employee performance is important because it is the foundation and direction of every organization. In this paper, we attempt to investigate the effect of self-efficacy on organizational commitment and employee performance, then the effect of organizational commitment on employee performance. The objectivity of the study refers to 100 informant units obtained through a survey of employees in the Tourism and Culture Office of East Kalimantan Province, Indonesia. The sampling approach uses a saturated sample method with Structural Equation Medelling-Partial Least Square (SEM-PLS). These findings indicate that self-efficacy has a significant effect on organizational commitment and employee performance. Similar to the previous results, organizational commitment has a significant effect on employee performance. With these findings, it can contribute to the role of a leader who must have optimal leadership characteristics, so that self-efficacy, organizational commitment, and employee performance continue to be optimal as expected.
О необходимости формирования цифровой компетентности у современного педагога как субъекта цифрового образовательного пространства
Authors: Компаниец А. А.
Published: August 2021

В XXI веке одним из центральных трендов в образовании является цифровизация образовательного процесса. Современному педагогу как непосредственному участнику цифровизации образования, как субъекту цифрового образовательного пространства следует понимать содержание основных категорий цифрового образовательного пространства. В частности, активное использование цифровых технологий и трансформирующиеся в связи с этим образовательные технологии приводят к пониманию необходимости формирования у современного педагога способности уверенно, эффективно, безопасно, критично, творчески и этично выбирать и применять цифровые технологии в своей профессиональной деятельности. В данной статье в широком понимании предложено содержание цифрового образовательного пространства. Представлен авторский взгляд на содержание феномена «цифровая компетентность педагога» в обозначенной структуре цифрового образовательного пространства. Рассмотрены две модели цифровой компетентности (Г.У. Солдатова, Joint Research Centre (JRC), the European Commission’s science and knowledge service). На основе обозначенных моделей цифровой компетентности предложен список актуальных цифровых компетенций, отражающих способность решать задачи из сфер контента, коммуникации и сотрудничества, обеспечения безопасности, решения технических проблем, потребления и технологических решений средствами цифровых инструментов. Проанализированы результаты анкетирования, проведенного среди учителей, преподавателей, студентов-бакалавров педагогического вуза как субъектов цифрового образовательного пространства. Выявлена заинтересованность респондентов в необходимости формирования цифровой компетентности в вопросах достоверного поис-ка информации, создания цифрового контента, организации онлайн-коммуникации и сотрудничества, обеспечения безопасности личных данных и устройств в сети Интернет. Выявлен «проблемный» компонент цифровой компетентности (организация безопасной деятельности в сети Интернет), на который следует обратить особое внимание при формировании цифровой компетентности у современного педагога на начальном этапе об-ращения к цифровому образовательному пространству.