bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Basic Metals. Part 64. Lewis‐Basic Bis(trimethylphosphine)cobalt Complexes with Indenyl and Trifluoromethylcyclopentadienyl as Ligands.
Authors: WERNER H. , MAHR J. , HOERLIN G. +
Published: May 2016

The half‐sandwich type compound (III) is prepared according to the scheme.
ChemInform Abstract: Coordination Chemistry of 1,3‐Dithiole‐2‐thione‐4,5‐diselenolate (dsit) ‐ Comparison with 1,3‐Dithiole‐2‐thione‐4,5‐dithiolate (dmit).
Authors: OLK R.‐M. , ROEHR A. + , SIELER J. , KOEHLER K. + , KIRMSE R. , DIETZSCH W. , HOYER E. , OLK B.
Published: May 2016

The bis(chelates) (IIIa) and (IIIb) are obtained according to the scheme.
ChemInform Abstract: Transition‐Metal Complexes with Sulfur Ligands. Part 44. Ruthenium(II) Complexes with the Sterically Demanding Thioether‐Thiolate Ligand “buS4”2‐(= 1,2‐Bis(3,5‐di(tertiarybutyl)‐2‐mercaptophenylthio)ethane (2‐)) and PPh3, CO, PMe3, NH3, and N2H4 Coligands.
Authors: SELLMANN D. , BARTH I.
Published: May 2016

The coordination properties of the sterically demanding ligand (I) toward Ru are investigated.
ChemInform Abstract: Novel Ruthenium‐Oxo Complexes of Saturated Macrocycles with Nitrogen and Oxygen Donors and X‐Ray Crystal Structure of trans‐(RuIV(L)O(H2O))(ClO4)2.
Authors: CHE C.‐M. , TANG W.‐T. , WONG W.‐T. , LAI T.‐F.
Published: May 2016

The aquo‐hydroxo‐complex (V) with the saturated macrocyclic ligand (I) having both N and O donor atoms serves as starting material for a new class of highly oxidizing Ru‐oxo‐complexes.
ChemInform Abstract: Synthesis of Some Heterobinuclear Compounds Containing Os‐Re Bonds and the Crystal Structure of the Heterobimetallic Anionic Complex (HOsRe(CO)8Br)PPN.
Authors: MOSS J. R. , NIVEN M. L. , SUTTON E. E.
Published: May 2016

The reaction of the anionic hydridoosmate (I) with the Re(I) bromide (II) gives the new heterobimetallic title complex (III) (space group P1, Z=2) and the neutral complex (IV).
ChemInform Abstract: Reactivity of Platinum and Palladium α‐Ketoacyl Complexes Toward Olefins and Acetylenes.
Authors: VETTER W. M. , SEN A.
Published: May 2016

The preparation of the title complexes (III) is described.
ChemInform Abstract: Studies in Steroidal (3,4‐c)‐1′,2′,5′‐Oxadiazoles.
Authors: YADAV M. R. , ABRAHAM J. , JINDAL D. P.
Published: May 2016

The stereochemistry at C‐5 of some steroidal dioximino derivatives during cyclization under different conditions is investigated.
ChemInform Abstract: Steroids. Part 347. Synthesis and in vitro Antimetabolic Evaluation of Some Steroidal Thiazoles.
Authors: DRASAR P. , POUZAR V. , CERNY I. , PETTIT G. R. , HAVEL M.
Published: May 2016

The title compounds (III) and (VI) are obtained by Hantzsch reaction of the bromide (I) which, in turn, is available by bromination of the respective pregnanone with CuBr2.
ChemInform Abstract: Addition of Arylzirconium Tributoxides to 17‐Ketosteroids.
Authors: KUMAR V. , BELL M. R.
Published: May 2016

The arylzirconium tributoxides (II), prepared from chlorozirconium tributoxide and aromatic organolithium or Grignard compounds, react with 17‐oxoandrosta‐2,4‐dieno(2,3‐d)isoxazole (I) to give the stereoisomeric aryl carbinols (III) and (IV).
ChemInform Abstract: Modified Synthesis of Monocyclic 1,2,3‐Triazine and Cycloaddition Reaction with Enamine: The Application to the Synthesis of Alkaloids, Tortuosamine, N‐Formyltortuosamine, and N‐Acetyltortuosamine.
Authors: OKATANI T. , KOYAMA J. , TAGAHARA K.
Published: May 2016

Oxidation of the N‐aminopyrazoles (I) with sodium periodate results in ring enlargement to produce the 1,2,3‐triazines (II) which undergo cycloaddition reaction with the pyrrolidine enamines (III) and (V) under release of nitrogen, yielding the (fused) pyridines (IV), (VI), or (VII).
ChemInform Abstract: Structurally Modified Antitumor Agents. Part 1. Synthesis of Cyclopropapyrrolo(1,2‐a)indoles Related to Mitosenes by Intramolecular Cycloaddition.
Authors: JONES G. B. , MOODY C. J.
Published: May 2016

A short route to the novel ring system (VI) is developed.
ChemInform Abstract: Gallium Coprecipitation Associated with Magnesium for Preconcentration of Trace Metals in Seawater.
Authors: AKAGI T. , FUWA K. , HARAGUCHI H.
Published: May 2016

It is found that the precipitation (by NaOH) of gallium from aqueous solutions strongly depends on the presence of Mg2+; Ga does not precipitate even at pH 9 when Mg2+ is absent.
ChemInform Abstract: Properties and Thermal Decomposition of the Double Salts of Uranyl Nitrate‐Ammonium Nitrate
Authors: NOTZ K. J. , HAAS P. A.
Published: May 2016

, NH4UO2(NO3)3 (I), (NH4)2UO2(NO3)4 (II), and (NH4)2UO2(NO3)4·2 H2O (III), are studied due to the importance of the thermal denitration process for the preparation of uranium oxides.
ChemInform Abstract: The Isothermal Section (500 °C) of the Phase Diagram of the Al‐Ho‐Si Ternary System
Authors: ZHUANG Y. , LI J. , ZENG L.
Published: May 2016

(≤ 40 at.% Ho) is studied by XRD, DTA, and electron probe microanalysis.
ChemInform Abstract: Hot Corrosion of Preoxidized Ni by a Thin Fused Na2SO4 Film at 900 °C.
Authors: OTSUKA N. , RAPP R. A.
Published: May 2016

The hot corrosion of preoxidized Ni (99% and 99.99% purity) covered with a thin fused Na2SO4 film in a SO2‐O2 atmosphere is studied by an electrochemical method using a sodium sensor and an oxygen probe.
ChemInform Abstract: Solubility of Hydrogen in Ti3In
Authors: RAMAPRABHU S. , RAJALAKSHMI N. , WEISS A.
Published: May 2016

is studied over the ranges 1‐1000 mbar and 923‐1123 K. The partial molar enthalpy of hydrogen solution at infinite dilution and the partial molar excess entropy of hydrogen solution at infinite dilution are determined to be ‐55.37 kJ/mol and ‐53.32 J/K·mol, respectively.
ChemInform Abstract: The Inter Alkali‐Metal Selenides KLiSe and KNaSe
Authors: HIPPLER K. , VOGT P. , WORTMANN R. , SABROWSKI H.
Published: May 2016

are prepared according to the scheme and characterized by Guinier photographs.
ChemInform Abstract: ESR of Homo‐ and Heteroleptic Mono‐ and Dinuclear Tris(α‐diimine)ruthenium Radical Complexes.
Authors: KAIM W. , ERNST S. , KASACK V.
Published: May 2016

The ESR data of 16 singly reduced tris(α‐diimine)ruthenium complexes are reported of which 6 are homoleptic, 5 mononuclear bis(bipyridine)ruthenium systems and 5 symmetrical dimers.
ChemInform Abstract: Spin Isolation of the (3Fe‐4S) Fragment of a (4Fe‐4S) Cluster: Electronic Properties of the (3Fe‐4S)0 Cluster.
Authors: WEIGEL J. A. , HOLM R. H. , SURERUS K. K. , MUENCK E. +
Published: May 2016

In an equilibrium system with (II) the cluster (III) is formed, which is investigated by Moessbauer spectra.
ChemInform Abstract: The Origin of Stereoselective Opening of Chiral Dioxane and Dioxolane Acetals: Solution Structure of Their Lewis Acid Complexes.
Authors: DENMARK S. E. , WILLSON T. M. , ALMSTEAD N. G.
Published: May 2016

Using variable‐temp.
ChemInform Abstract: Electrochemical Reduction of the Antitumor Anthrapyrazole CI‐941: Mechanism of Formation and Isolation of the Leuco Form.
Authors: ANNE A. , MOIROUX J.
Published: May 2016

The anticancer drug (I) is converted into its leuco form (II) via a two‐electron reduction in the presence of proton donors such as H2O or via two successive one‐electron reductions in DMF.
ChemInform Abstract: Oxygen Atom Transfer Catalyzed by an Oxo‐Bridged Molybdenum(V) Compound.
Authors: BAIRD D. M. , FALZONE S. , HAKY J. E.
Published: May 2016

It is shown that the title complex (I) can be used to reduce a variety of oxygen atom donating heterocyclic amine oxides and sulfoxides, including pyridine and nicotinamide N‐oxide, DMSO and biotin S‐oxide in either CH2Cl2 or THF.
ChemInform Abstract: New Investigations of the Reaction of Epichlorohydrin with Hindered Amines: X‐Ray and NMR Analyses.
Authors: LAGUERRE M. , BOYER C. , LEGER J.‐M. , CARPY A.
Published: May 2016

The reaction of epichlorohydrin (II) with prim. amines such as (I) yields the acetidinols of type (III) having the OH group and the nitrogen substituent on the same side of the acetidine ring.
ChemInform Abstract: Radical Cations from One‐Electron Oxidation of Aliphatic Sulfoxides in Aqueous Solution. A Radiation Chemical Study.
Authors: KISHORE K. , ASMUS K.‐D.
Published: May 2016

The title radical cations (II) are generated from (I) by strongly oxidizing radicals (obtained radiolytically) at low pH values.
ChemInform Abstract: Reaction of 4‐Hydroxycoumarin Derivatives with Activated Dimethyl Sulfoxide.
Authors: APPENDINO G. , TAGLIAPIETRA S. , NANO G. M. , PALMISANO G.
Published: May 2016

In the course of studies on the haemorrhagic toxins from Ferula communis L. the oxidation of isomeric ω‐hydroxyferulenols such as (I) to the corresponding aldehydes is needed.
ChemInform Abstract: Oxidation of N‐Alkylamides to Novel Hydroperoxides by Dioxygen.
Authors: DRAGO R. S. , RILEY R.
Published: May 2016

The frequently used solvent (I) forms the hydroperoxide (II) which is converted to N‐methylsuccinimide (III) by peroxide decomposition catalysts.
ChemInform Abstract: Hydrogenolysis of Differently Substituted Methoxyphenols.
Authors: BREDENBERG J. B. , HUUSKA M. , TOROPAINEN P.
Published: May 2016

The hydrogenation of (I) and its isomers shows reactivities decreasing in the order p > o > m in the temp. range 275‐325 °C. The ring methylation follows the opposite order.
ChemInform Abstract: A Convenient Preparation of Mono‐ or gem‐Dihalogenoalkenes from α‐Sulfonyl Carbanions and Halogenolithiocarbenoids.
Authors: CHARREAU P. , JULIA M. , VERPEAUX J.‐N.
Published: May 2016

Various α‐sulfonyl carbanions such as those derived from (I) are shown to react at low temperature with di‐ or trihalogenolithiocarbenoids.
ChemInform Abstract: Organophosphorus Compounds. Part 120. Experiments for the Detection of “Phosphenes” Generated from Suitable Phosphinic Acid Derivatives by Elimination.
Authors: WEIDERT P. J. , GEYER E. , HORNER L.
Published: May 2016

Reaction of benzylphenylphosphinic acid fluoride (I) with benzaldehyde (II) in the presence of strong bases yields stilbene (III).
ChemInform Abstract: Electrochemical Synthesis of 1,1‐Dichloro‐4‐methylpenta‐1,3‐diene (IV).
Authors: FECHTEL U. , MATSCHINER H.
Published: May 2016

With regard to the production of the insecticide permethrin, the electrochemical synthesis of the intermediate (IV) is studied starting from (I).
ChemInform Abstract: Synthesis and Some Reactions of 2‐Acylcyclopentane‐1,3‐diones.
Authors: LAKHVICH F. A. , KHLEBNIKOVA T. S. , AKHREM A. A.
Published: May 2016

In the presence of Py the reaction between 1,3‐cyclopentanedione (I) and the acyl chlorides (II) affords the 2‐acyl derivatives (III).
ChemInform Abstract: Tiffeneau‐Demjanov Ring Homologations of Two Pentacyclo‐(5.4.0.02,6.03,10.05,9)undecane‐8,11‐diones.
Authors: MARCHAND A. P. , RAJAPAKSA D. , REDDY S. P. , WATSON W. H. , NAGL A.
Published: May 2016

The pentacycloundecanes (I) mentioned in the title are converted to the amines (IV) by reaction with nitromethane (II) and subsequent catalytic hydrogenation of the adduct (III).
ChemInform Abstract: Towards Chiral Reformatskii Reagents.
Authors: BASAVAIAH D. , BHARATHI T. K.
Published: May 2016

The chiral bromoacetates (I), (IV), and (V), derived from lactic acid, are subjected to Reformatskii reaction with the carbonyl compounds (II) or (VI) to yield the β‐hydroxycarboxylic acids (III) or (VII).
ChemInform Abstract: Synthesis of 3‐Methyl‐4‐Substituted Butenolides Using Regioselective Reaction of Phenylsulfonylbutenolide.
Authors: YODA H. , SHIRAKAWA K. , TAKABE K.
Published: May 2016

The butenolide (I) is brominated and then treated with sodium benzenesulfinate (II) to form the sulfone (III).
ChemInform Abstract: Synthesis and Antimicrobial Activity of 5‐Substituted 2‐Iminopyrrolidines.
Authors: BESPALOVA G. V. , SEDAVKINA V. A. , KULIKOVA L. K.
Published: May 2016

Reaction of the pyrrolidinethiones (I) with the amines (II) gives the iminopyrrolidines (III) of which (IIIa) and (IIIb) are coupled with the furfurol (IV), producing the condensation products (V).
ChemInform Abstract: N‐Glucosylation of Aminoindoles and Bisglucosides of 5‐Aminoindole.
Authors: SALEKH M. A. , KRASAVINA L. S. , VIGDORCHIK M. M. , TURCHIN K. F. , SAPUKOVA A. A. , ANISIMOVA O. S. , SUVOROV N. N.
Published: May 2016

The reactions between the aminoindoles (Ia) and (Ib) and D‐glucose (II) yield the N‐β‐D‐glucopyranosides, which are converted into the O‐acetyl derivatives without change of their configuration.
ChemInform Abstract: Reaction of 4‐Methylpyrano(3,4‐b)indol‐3‐one with (Dimethyltriazen‐1‐yl)pyridinecarboxylic Acids, Precursors of 3,4‐Pyridynes.
Authors: MODI S. P. , ARCHER S.
Published: May 2016

Reaction of the triazene (VII), prepared from the pyridine (I) as shown in the reaction scheme, with the pyranoindole (VIII) does not afford the desired 6H‐pyrido(4,3‐b)carbazole.
ChemInform Abstract: Synthetic Photochemistry. Part 52. Substituent Effects of a Bromine Atom on the High‐Pressure Cycloaddition Between 1‐Acetyl‐7‐bromocyclohepta(b)pyrrol‐2(1H)‐one and 2,3‐Bis(methoxycarbonyl)‐7‐oxanorbornadiene and the Photorearrangement of 2‐Acetyl‐9‐bromo‐2‐azatricyclo(6.2.2.01,5)dodeca‐4,6,9,11‐tetraen‐3‐one.
Authors: TIAN G. R. , MORI A. , TAKESHITA H.
Published: May 2016

The high‐pressure cycloaddition reaction of the 7‐bromocycloheptapyrrole (Ia) with the diester (II) affords (4 + 2) adducts as main products (cf.
ChemInform Abstract: Stereoselective Arylation of Pyranoid Glycals, Using Bromomagnesium Phenolates: An Entry to 2,3‐Unsaturated C‐α‐Glycopyranosylarenes.
Authors: CASIRAGHI G. , CORNIA M. , RASSU G. , ZETTA L. , FAVA G. G. , BELICCHI M. F.
Published: May 2016

Reaction between the D‐glucal (I) and the magnesium salts (II) gives the arylated derivatives (III) and (IV).
ChemInform Abstract: The Synthesis of Some Dimethylpyranocoumarins and Isopropenyldihydrofuranocoumarins.
Authors: YAMAGUCHI S. , MIYAKAWA R. , YONEZAWA S. , KAWASE Y.
Published: May 2016

Treatment of the aldehydes (IV), (IX) and (XII) according to A) renders possible a new approach to the title ring systems which in part represent naturally occurring coumarins.
ChemInform Abstract: Imidolactones. Part 3. N‐(3‐Phenylpropyl)isochroman‐1‐imines.
Authors: MEISE W. , SCHLUETER G. +
Published: May 2016

The isochromaniminium chlorides (II), produced by cyclization of the o‐(hydroxyethyl)benzamides (I) with thionyl chloride, isomerize upon heating in acetonitrile to give the chlorides (III).
ChemInform Abstract: Synthesis and Cardiotropic Activity of Stereoisomeric 1‐(2‐(3,4‐Dimethoxyphenyl)ethyl)‐2‐methyl‐4‐ethynyl‐4‐acyloxy‐trans‐decahydroquinolines.
Authors: FISHCHUK E. V. , PRALIEV K. D. , MAL'CHIKOVA L. S. , ORANOVSKAYA E. V.
Published: May 2016

The carbinols (I) are coupled with the carboxylic chlorides (II) or (IV) to give the esters (III).
ChemInform Abstract: Diastereofacial Selectivity in the Cycloaddition of Chiral Glyoxylate Imines to Cyclopentadiene and Indene: Synthesis of Optically Active Tetrahydroquinolines.
Authors: BORRIONE E. , PRATO M. , SCORRANO G. , STIVANELLO M. , LUCCHINI V. , VALLE G.
Published: May 2016

The cycloaddition of the imine (II) with cyclopentadiene (I) or indene (V) yields the tetrahydroquinolines (III) and (IV) or (VI) (space group P212121, Z=4) and (VII) with high diastereoisomeric selectivity, when (‐)‐8‐phenylmenthol (Pme) is used as chiral auxiliary.
ChemInform Abstract: Benzene Derivatives from Pyrans: 5‐Aminochromones and 5‐Aminoflavones from 3‐Acetyl‐2,6‐dimethyl‐4H‐pyran‐4‐one.
Authors: EIDEN F. , PATZELT G. , BUCHBORN H.
Published: May 2016

Reaction of the pyrone (I) with the amines (II) yields the cyclohexenones (III).
ChemInform Abstract: The Synthesis and Complex Formation of Dibenzo(e,k)‐2,3‐bis(hydroxyimino)‐1,4‐diaza‐7,10‐dithia‐2,3,8,9‐tetrahydrocyclododecine.
Authors: GOEK Y. + , DEMIRBAS A.
Published: May 2016

The o‐aminothiophenolate (I) reacts with 1,2‐dibromoethane (II) to give the 1,2‐bis(o‐aminophenylthio)ethane (III).
ChemInform Abstract: Diphosphabicyclobutane.
Authors: NIECKE E. , METTERNICH H. J. , STREUBEL R.
Published: May 2016

The two isomeric title compounds (II) and (IV) are obtained by treatment of the phosphaalkenes (I) and (III) with Mg or Na.
ChemInform Abstract: 2‐Chloro‐1‐thia‐2‐phosphiranes, Synthesis, and Reactions. Evidence for the 1,3‐Dipole PhC+c=P‐5‐.
Authors: MAERKL G. + , HOELZL W. +
Published: May 2016

Reaction of the methyloxathiazolone (I) with the methylenechlorophosphines (II) produces the thiaphosphiranes (III) and (IV).
ChemInform Abstract: (Cycloalkyl(phenylseleno)methylene)triphenylphosphoranes: Synthesis and Reactions of (Phenylseleno)alkenes.
Authors: MINAMI T. , UMEZU Y. , SHIKITA S. , OKADA Y.
Published: May 2016

Wittig reaction of the phosphoranes (I) and (XI) with the aldehydes (II) gives (Z)‐ and (E)‐configurated (phenylseleno)alkenes, e.g. (III), (IV), (VII) and (XIII).
ChemInform Abstract: Synthesis of Unsymmetrical Bidentate and Tridentate Phosphines by (4 + 2) Diels‐Alder Cycloadditions and Michael Additions of (Phosphole)‐ and (Vinylphosphine)molybdenum Carbonyl Complexes.
Authors: AFFANDI S. , NELSON J. H. , FISCHER J.
Published: May 2016

The reaction of divinylphenylphosphine (II) with the phosphole‐Mo complex (I) yields two diastereomers of the (4 + 2) Diels‐Alder cycloadduct (III).
ChemInform Abstract: Cobalt Carbonyl Complexes of Functional Ethynylsilanes. Reactivity at the Silicon Atom.
Authors: CORRIU R. J. P. , MOREAU J. J. E. , PRAET H.
Published: May 2016

The reaction of various functional ethynylsilanes such as (I) and (V) with Co2(CO)8 (II) yields corresponding acetylene‐cobalt carbonyl complexes.
ChemInform Abstract: Complexes of the Platinum Metals. Part 35. 4,6‐Dimethylpyrimidine‐2‐thiol Derivatives of Ruthenium, Osmium, Rhodium and Iridium.
Authors: OLBY B. G. , ROBINSON S. D.
Published: May 2016

Reactions of the title ligand and its oxidation product bis(4,6‐dimethylpyrimidine‐2‐yl)disulfide with a range of hydrido(chloro)carbonyl(triphenylphosphine) complexes of Ru, Os, Rh, and Ir are described.
ChemInform Abstract: New Modes of Thiophene Coordination and Reactivity: Structures of Cp*Ir(η2‐thiophene), an Iridathiabenzene, and Cp*Ir(η4‐thiophene·BH3).
Authors: CHEN J. , DANIELS L. M. , ANGELICI R. J.
Published: May 2016

In order to understand the mechanism of the heterogeneously catalyzed hydrodesulfurization of thiophenes, possible modes of their coordination and subsequent reactions are investigated.
ChemInform Abstract: CO Labilization and Intramolecular Hydride Transfer Reactions in Group VI (Cr, Mo, W) Metal‐Platinum Heterobimetallic μ‐Phosphido Hydrido Carbonyl Complexes.
Authors: POWELL J. , GREGG M. R. , SAWYER J. F.
Published: May 2016

Oxidative addition of the P‐H bond of the sec. phosphine complexes (I) to the Pt(0) complex (II) gives the phosphide‐bridged products (III) which loses rapidly CO (reversible process) to give the μ‐hydrido‐μ‐phosphido complexes (IVa) via a Pt‐assisted mechanism.
ChemInform Abstract: Synthesis of “PtRu2” and “PtRu3” Heterometallic Complexes from the Reaction of Ru3(CO)11(PPh2H) with Zerovalent Complexes of Platinum. Single‐Crystal X‐Ray Diffraction Studies of PtRu2(μ‐PPh2)(μ‐H)(CO)7(PCy3) and PtRu3(μ‐PPh2)(μ‐H)(CO)9(PCy3).
Authors: POWELL J. , BREWER J. C. , GULIA G. , SAWYER J. F.
Published: May 2016

The reaction of the Ru3 cluster (I) with the tricyclohexylphosphine‐Pt(0) complex (II) gives the tetranuclear PtRu3 cluster (III) (space group P21/c, Z=4) and the trinuclear Ru2Pt cluster (IVa) ( P21/n, Z=4) as the major products together with several minor "RuxPty" species.
ChemInform Abstract: Coriamyrtin and Tutin. A Crystallographic and Conformational Study.
Authors: GULBIS J. M. , MACKAY M. F. , WONG M. G.
Published: May 2016

The structural and pharmacological similarity of coriamyrtin (Ia) (space group P212121; Z=4) and tutin (Ib) (space group P1; Z=1) to picrotoxinin suggests that all three compounds (convulsants from Coriaria species) act as the same inhibitory synapses and utilize the same binding site.
ChemInform Abstract: Synthesis of α‐Damascone and 1‐(2,6,6‐Trimethyl‐2‐tetrahydropyranyl)‐2‐alken‐1‐ones.
Authors: ERMAN M. B. , PRIBYTKOVA I. M. , GULYI S. E. , BOGOMOLOVA O. A. , CHERKAEV G. V. , AUL'CHENKO I. S. , MOCHALIN V. B.
Published: May 2016

α‐Damascone (V) is prepared starting from α‐cyclocitral (I) by a novel and more convenient procedure.
ChemInform Abstract: Preparation and Conformational Analysis of Vancomycin Hexapeptide and Aglucovancomycin Hexapeptide.
Authors: BOOTH P. M. , WILLIAMS D. H.
Published: May 2016

The preparations of the hexapeptides (Ib) and (Ic) derived from the antibiotic (Ia) and its agluco derivative are described.
ChemInform Abstract: Asymmetric Reduction of the Prochiral Carbon‐Carbon Double Bond of Methyl 2‐Chloro‐2‐alkenoates by Use of Fermenting Bakers′ Yeast.
Authors: UTAKA M. , KONISHI S. , MIZUOKA A. , OHKUBO T. , SAKAI T. , TSUBOI S. , TAKEDA A.
Published: May 2016

Asymmetric reduction of the methyl E‐2‐chloroalkenoates (I) using fermenting bakers yeast gives the corresponding methyl 2‐chloroalkanoates (R)‐(II) with moderate up to satisfactory optical purity.
ChemInform Abstract: Reactive Ion Etching of SiC Thin Films by Mixtures of Fluorinated Gases and Oxygen
Authors: PAN W.‐S. , STECKL A. J.
Published: May 2016

(SF6, CBrF3, and CHF3) is investigated.
ChemInform Abstract: High Frequency Capacitance‐Voltage Characteristics of Thermally Grown SiO2 Films on β‐SiC.
Authors: TANG S. M. , BERRY W. B. , KWOR R. , ZELLER M. V. , MATUS L. G.
Published: May 2016

SiO2 films on β‐SiC are thermally grown either under dry (O2 stream, 1000 °C) or wet (argon stream loaded with H2O vapor, 1150 °C) conditions and studied by C‐V measurements.
ChemInform Abstract: 95Mo NMR and Vibrational Spectroscopic Studies of Molybdenum(VI) Species in Aqueous Solutions and Solvent Extracts from Hydrochloric and Hydrobromic Acid: Evidence for the Complexes (Mo2O5(H2O)6)2+, (MoO2X2(H2O)2) (X: Cl or Br), and (MoO2Cl4)2‐.
Authors: CODDINGTON J. M. , TAYLOR M. J.
Published: May 2016

The NMR, IR, and Raman spectroscopic results obtained for acidified Na2MoO4 solutions indicate the presence of the species (Mo7O24)6‐, (Mo8O26)4‐, and (Mo36O112(H2O)16)8‐. In 2‐6 M HNO3 or HClo4 solutions of Na2MoO4, (Mo2O5(H2O)6)2+ is identified as predominant Mo(VI) species.
ChemInform Abstract: Aqueous Isopolymolybdates(VI): An Oxygen‐17 and Molybdenum‐95 NMR Study.
Authors: HOWARTH O. W. , KELLY P. , PETTERSSON L.
Published: May 2016

(Mo7O24)6‐, (HMo7O24)5‐, and (Mo8O26)4‐ are clearly detected in acidified aqueous solutions of (MoO4)2‐ (pH 1.2‐6) by 17O and 95Mo NMR.
ChemInform Abstract: Low‐Temperature (144 K) 129Xe NMR Studies of Zeolites
Authors: CHEUNG T. T. P.
Published: May 2016

(offretite, silicalite, zeolites L and CaA).
ChemInform Abstract: Photoelectrochemistry and Interfacial Energetics of Titanium Dioxide Photoelectrodes in Fluoride‐Containing Solutions
Authors: WANG C. M. , MALLOUK T. E.
Published: May 2016

such as anhydrous HF/NaF and MeCN/Et4NF solutions are studied by I‐V and ac impedance measurements.
ChemInform Abstract: A Molybdate Treatment for Enhancing the Passivity of Aluminum in Chloride‐Containing Environments.
Authors: SHAW B. A. , DAVIS G. D. , FRITZ T. L. , OLVER K. A.
Published: May 2016

It is demonstrated that the pitting resistance of aluminum can be significantly improved by electrochemical incorporation of Mo into the aluminum passive film.
ChemInform Abstract: Formation of Perovskite Structure La1‐xCaxCrO3 Films by Electrodeposition.
Authors: KONNO H. , TOKITA M. , FURUICHI R.
Published: May 2016

Cathodic polarization of a Pt electrode in an aqueous solution of La(NO3)3, Ca(NO3)2, and (NH4)2Cr2O7 (pH 2.3) results in the deposition of a (LaOH)1‐xCax(CrO4)·nH2O film.
ChemInform Abstract: Addition of Cyanide Ion to Nicotinamide Cations in Acetonitrile. Formation of Non‐Productive Charge‐Transfer Complexes.
Authors: ENGBERSEN J. F. J. , KOUDIJS A. , SLEIDERINK H. M. , FRANSSEN M. C. R.
Published: May 2016

Mixing of equal amounts of 1‐benzylnicotinamides (Ia) and KCN (II) results in the immediate formation of a transient absorption band at 375 nm which is ascribed to a CT complex.
ChemInform Abstract: Synthesis and Transannular Diels‐Alder Reaction of a cis‐trans‐trans and a trans‐cis‐cis 13‐Membered Macrocyclic Trienone.
Authors: MARINIER A. , BAETTIG K. , DALLAIRE C. , PITTELOUD R. , DESLONGCHAMPS P.
Published: May 2016

Both the title compounds (I) and (V) are prepared in 13‐15 steps starting from cyclohexene.
ChemInform Abstract: Concomitant (2,3)Sigmatropic Rearrangement of Allylic Sulfilimines and Intramolecular N‐Alkylation. Synthesis of 2‐Vinyl‐Substituted Cyclic Amines.
Authors: DOLLE R. E. , LI C.‐S. , SHAW A. N.
Published: May 2016

The ω‐bromo or ω‐tosyloxy allylic sulfides (I) undergo amination accompanied by cyclization upon consecutive treatment with chloramine T, triethyl phosphite, and aqueous sodium hydroxide, yielding the N‐tosyl‐2‐vinylazacycloalkanes (III).
ChemInform Abstract: Captodative Substituent Effects. Part 49. ESR Study of Carbon‐Centered Transient Radicals Using α‐tert.‐Butylthioacrylonitrile as Radical Trap.
Authors: MERENYI R. , JANOUSEK Z. , VIEHE H. G. , MIGNANI S.
Published: May 2016

The title compound (III) is found to be the most useful radical trap because of its easy synthesis, its aptitude to trap nucleophilic as well as electrophilic radicals such as (II) (a total of 29 examples is tabulated), and the facile interpretation of the ESR spectra of radical adducts (IV) which are in equilibrium with their dimers (V).
ChemInform Abstract: Addition of Cyclohexane to Slowly Reacting H2‐O2 Mixtures at 480 °C.
Authors: GULATI S. K. , WALKER R. W.
Published: May 2016

The kinetics of the reactions OH + c‐C6H12 → c‐C6H11 + H2O (k = (1.41 ±0.20)·1010) and H + c‐C6H12 → c‐C6H11 + H2 (k = (2.8 ±0.4)·109 dm3/mol·s) measured show that the rates of H and OH attack on an individual CH2 group in cyclohexane and in linear alkanes are effectively indistinguishable.
ChemInform Abstract: Stereoselective Hydrogenation via Dynamic Kinetic Resolution.
Authors: NOYORI R. , IKEDA T. , OHKUMA T. , WIDHALM M. , KITAMURA M. , TAKAYA H. , AKUTAGAWA S. , SAYO N. , SAITO T. , TAKETOMI T. , KUMOBAYASHI H.
Published: May 2016

The Ru‐catalyzed hydrogenation of the racemic ketones (I) proceeds stereoselectively to provide nearly exclusively the syn‐((2S,3R)‐) alcohols (II).
ChemInform Abstract: Thiols as Polarity Reversal Catalysts for Hydrogen‐Atom Transfer from Organosilanes to Alkyl Radicals: Reduction of Alkyl Halides by Triethylsilane.
Authors: ALLEN R. P. , ROBERTS B. P. , WILLIS C. R.
Published: May 2016

The alkyl halides (I) are reduced with triethylsilane in the presence of di‐tert‐butyl hyponitrite and tert‐dodecanethiol, producing the alkanes (II).
ChemInform Abstract: The “Naked Fluoride”: Myth or Reality.
Authors: RIEUX C. , LANGLOIS B. , GALLO R.
Published: May 2016

The high nucleophilic reactivity of quaternary ammonium fluorides ("naked fluorides") is applied in fluorination of aromatics, e.g. (I), by halogen exchange.
ChemInform Abstract: Conversion of Long‐Chain Terminal Alcohols and Secondary Amines into Tertiary Amines Using Dichlorotris(triphenylphosphine)ruthenium(II) as Catalyst.
Authors: GANGULY S. , JOSLIN F. L. , ROUNDHILL D. M.
Published: May 2016

The title complex acts as a homogeneous catalyst for the conversion of terminal alcohols such as (I) and secondary amines (II) into tertiary amines (III) (16 examples given in a table).
ChemInform Abstract: Unequivocal Synthesis of the Four d,l‐Pairs of 3‐Substituted 2‐Aminonorbornane‐2‐carboxylic Acids.
Authors: AVENOZA A. , CATIVIELA C. , MAYORAL J. A. , ROY M. A.
Published: May 2016

The cycloadducts (III) and (IV) are obtained by Diels‐Alder reaction of the components (I) and (II).
ChemInform Abstract: Cyclohepta(l)phenanthrenylium Ions. Intramolecular Cyclization of 2‐Biphenylylcycloheptatrienes.
Authors: YAMAMURA K. , MIYAKE H. , AZUMI K. , MURATA I.
Published: May 2016

The 2‐biphenylylcycloheptatrienes (I) ‐ (IV) react with 1 equiv. of trityl tetrafluoroborate (V) to yield the tropylium salts (VI).
ChemInform Abstract: Biomimetic Radical Cyclizations: Synthesis and Biosynthesis of Benzodihydropyrans and ‐furans.
Authors: WALKINGTON A. J. , WHITING D. A.
Published: May 2016

The thiohydroxamate (I) is irradiated in the presence of acrylonitrile (II), tributylstannane, and AIBN to produce the cyanopropylphenol ether (III).
ChemInform Abstract: Synthesis and Antifungal Activity of Some Amidrazone Derivatives.
Authors: VIO L. , MAMOLO M. G. , RONSISVALLE G. , OLIVERI S. , GREGO A. M.
Published: May 2016

The cyanopyridines (I) react with hydrazine (II), forming the amidrazones (III) which are coupled with the hetaromatic aldehydes (IV) to produce the hetarylmethylenamidrazones (V).
ChemInform Abstract: Novel Entry to the Tropane System by Reaction of Rhodium(II) Acetate‐Stabilized Vinylcarbenoids with Pyrroles.
Authors: DAVIES H. M. L. , YOUNG W. B. , SMITH H. D.
Published: May 2016

The unsaturated diazo compounds (II) react with the N‐carboxyalkylpyrroles (I) in the presence of dirhodium tetraacetate to give the 8‐azabicyclo(3.2.1)octadienes (III).
ChemInform Abstract: The Synthesis and Structure of (7)(3,6)Pyridazinophane.
Authors: GASSMAN P. G. , BOARDMAN G. S.
Published: May 2016

The Diels‐Alder adduct (III), derived from the cycloundecadiene (I) and the triazolinedione (II), is converted to the epoxide (IV) which is cleaved, forming the isomeric semicarbazides (V) and (VI).
ChemInform Abstract: Cycloaddition Reactions of Heteroazadienes. The First Intramolecular Diels‐Alder Reaction of 1‐Thia‐3‐azabutadienes.
Authors: BARLUENGA J. , TOMAS M. , BALLESTEROS A. , LOPEZ L. A.
Published: May 2016

Reaction of the unsaturated N‐(trimethylsilyl)imines (I) or (VI) with the isothiocyanates (II) results in cyclization to produce the tricyclic trans‐fused 2‐imino‐1,3‐thiazines (III) or (VII).
ChemInform Abstract: Synthesis of Some Derivatives of the New Ring System Pyrrolo(3,4‐f)(1,5)diazocine.
Authors: ZANKOWSKA‐JASINSKA W. , OSTROWSKA K.
Published: May 2016

The novel title compounds (III) may be of pharmacological interest, since the analogous pyrrolo(3,4‐e)(1,5)diazocines are used as tranquilizers or antihypertensive agents.
ChemInform Abstract: A Metal‐Directed Pyrazoline ‐ 1,5‐Diazapentadiene Rearrangement of a Novel (2 + 2)Macrocycle: Crystal and Molecular Structures of L3 and (Ni2(L2))·5H2O.
Authors: CONSTABLE E. C. , DOYLE M. J. , ELDER S. M. , RAITHBY P. R.
Published: May 2016

Pyridine‐2,6‐dicarbohydrazide (I) cyclizes with pentane‐2,4‐dione (II) to produce the macrocyclic hydrazide (III) which reacts with nickel(II) acetate (IV) under rearrangement, yielding the V‐shaped binuclear complex (V).
ChemInform Abstract: The Reactions of 3‐Acetyl‐2H‐1‐benzopyran‐2‐ones with Ammonia and Ammonium Acetate.
Authors: O'CALLAGHAN C. N. , MCMURRY T. B. H.
Published: May 2016

The reaction of two equivalents of the acetylbenzopyranone (I) with one equivalent of NH3 (II) or AcONH4 (IV) leads to the products (III) or (V).
ChemInform Abstract: A Novel Macrocycle Containing the 4,5‐Dithio‐1,3‐dithiole‐2‐thione Unit and a Related Macrocycle Incorporating the Tetrathiafulvalene Moiety.
Authors: GIRMAY B. , KILBURN J. D. , UNDERHILL A. E. , VARMA K. S. , HURSTHOUSE M. B. , HARMAN M. E. , BECHER J. , BOJESEN G.
Published: May 2016

The bis(benzoylthio)dithiolethione (I) is converted into the dimercapto disodium salt (III) which reacts with 2,6‐bis(bromomethyl)pyridine (IV) to form the macrocycle (V).
ChemInform Abstract: A New Route to Highly Enantiomerically Enriched (Z)‐(1‐Methyl‐2‐butenyl)boronic Esters.
Authors: STUERMER R. +
Published: May 2016

The boronic ester (III) is obtained by the diastereoselective reaction of the chiral borate (I) with one isomer of a racemic mixture of the Grignard reagent (II).
ChemInform Abstract: New Dihydrazido and Oxyamido Derivatives of Phosphoric and Thiophosphoric Acid with Bis(2‐chloroethyl)amido Substituents.
Authors: GIERSDORF K. , DIEFENBACH U. , ENGELHARDT U.
Published: May 2016

The reaction of (Ia) with 1,2‐dimethylhydrazine (II) gives the dihydrazide (III), whereas the corresponding reaction of (Ib) yields the monosubstitution product (VI).
ChemInform Abstract: Unexpected Synthesis of a 1,4‐Diaza‐2σ3λ3,3σ4λ5‐diphospholene.
Authors: MAJORAL J.‐P. , ROQUES C. , MAZIERES M. R. , JAUD J. , SANCHEZ M.
Published: May 2016

Treatment of the bissilyldichlorophosphine (I) with the N‐silylated phenylamidine (II) results in cyclization, producing the diazadiphospholene (III).
ChemInform Abstract: Reaction of VOCl3 with Alcohols in the Presence of Nitrogen‐Containing Hydrogen Chloride Acceptors.
Authors: MAGOMEDOV G. K. I. , MOROZOVA L. V. , KUSAINOVA K. M. , BLOKHINA E. I. , MEDVEDEVA A. V. , BELETSKAYA I. P.
Published: May 2016

The preparation of the trialkyl vanadates (III) from vanadyl chloride (I) and the alcohols (II) in the presence of bases is studied in detail.
ChemInform Abstract: Synthesis, Molecular and Electronic Structure, and Properties of Mononuclear Trimethylphosphine‐Containing Cyclopentadienyl Derivatives of Molybdenum(III) and Molybdenum(IV). Direct Evidence of Mo(III)‐P π Back‐Bonding.
Authors: KRUEGER S. T. , POLI R. , RHEINGOLD A. L. , STALEY D. L.
Published: May 2016

The Mo(III) complexes (IV) are paramagnetic, low‐spin, mononuclear 17‐electron compounds.
ChemInform Abstract: Formation of Bis(o‐benzosemiquinonediiminato)cobalt(III) Derivatives by Oxidation of o‐Phenylenediaminecobalt(II) Complexes with O2.
Authors: NEMETH S. , SIMANDI L. I. , ARGAY G. , KALMAN A.
Published: May 2016

On exposure to pure O2 of a MeOH solution containing Co(II) perchlorate (I), two equiv. o‐phenylenediamine (II) and two equiv. EPh3 (III), the square pyramidal Co(III) complexes (IV) are formed.
ChemInform Abstract: Isolation, Characterization, and Kinetics of Formation of the cis and trans Isomers of Bis(acetonitrile)dichloroplatinum(II).
Authors: FANIZZI F. P. , INTINI F. P. , MARESCA L. , NATILE G.
Published: May 2016

By the known standard procedure a mixture of the cis and trans isomers (III) and (IV) is obtained.
ChemInform Abstract: Combined Chemoenzymatic Synthesis of N‐Glycoprotein Building Blocks.
Authors: THIEM J. , WIEMANN T.
Published: May 2016

Partial structures of N‐glycoproteins are of importance for biological recognition processes.
ChemInform Abstract: Structural Variations of N‐Acetylneuraminic. Part 15. Synthesis of 9‐Deoxy‐, 7,9‐Dideoxy‐, and 4,7,9‐Trideoxy‐N‐acetylneuraminic Acid and Their Behavior Toward CMP‐Sialate Synthase.
Authors: SCHREINER E. , CHRISTIAN R. , ZBIRAL E.
Published: May 2016

The procedures used for the synthesis of the title compound (VI) are also applied to the preparation of the derivatives (IX) and (XII) (no yield given).
ChemInform Abstract: Sulfur‐Containing Polybromoindoles from the Red Alga Laurencia brongniartii.
Authors: TANAKA J. , HIGA T. , BERNARDINELLI G. , JEFFORD C. W.
Published: May 2016

The new polybromoindoles (I), (II) (space group P21/c; Z=4), (III) (space group P21/n; Z=4) and (VII) are isolated from the title species.
ChemInform Abstract: Stereochemistry of Bisoxiranes of Vitamin D3‐4‐Phenyl‐triazoline‐3,5‐dione Adducts: X‐Ray Structure Analysis of One of Their Benzoyl Derivatives.
Authors: REISCHL W. , KRATKY C. , SHELDRICK G. M. , ZBIRAL E.
Published: May 2016

Complete epoxidation of the vitamin D3‐phenyltriazolinedione adducts (I) with MCPBA generates four diastereomeric bisoxiranes such as (IIa).
ChemInform Abstract: A Convenient Preparation of (8R),25‐Dihydroxy‐9,10‐seco‐4,6,10(19)‐cholestatrien‐3‐one.
Authors: REISCHL W.
Published: May 2016

The title compound (III), a new metabolite of 25‐hydroxyvitamin D3 (I) from the murine myeloid leukemia cell line M 1, is available from (I).
ChemInform Abstract: Enzymatic Asymmetric Hydroxylation of Pentadienols Using Soybean Lipoxygenase.
Authors: ZHANG P. , KYLER K. S.
Published: May 2016

An enzymatic method is reported for the asym.
ChemInform Abstract: Enzymes in Organic Synthesis. Part 15. Enzymatic Preparation of Optically Active Cyanohydrin Acetates.
Authors: VAN ALMSICK A. , BUDDRUS J. , HOENICKE‐SCHMIDT P. + , LAUMEN K. , SCHNEIDER M. P.
Published: May 2016

Enzymatic hydrolysis of the racemic cyanohydrin acetates (I) at a constant pH followed by work‐up of the product mixture yields the optically active cyanohydrin acetates (II).
ChemInform Abstract: Dip‐Coating of Sb‐Doped SnO2 Films by Ethanolamine‐Alkoxide Method.
Authors: TAKAHASHI Y. , WADA Y.
Published: May 2016

Transparent, highly conducting thin Sb‐doped SnO2 films are deposited on glass substrates by a dip‐coating method using a solution of Sn(O‐iPr)4, Sb(OEt)3, isopropanol, triethanolamine, and H2O. The resistivity of the films slightly depends on their thickness.
Association Between Sedentary Lifestyle and Diastolic Dysfunction Among Outpatients With Normal Left Ventricular Systolic Function Presenting to a Tertiary Referral Center in the Middle East
Authors: Matta Stephanie , Chammas Elie , Alraies Chadi , Abchee Antoine , AlJaroudi Wael
Published: May 2016

Background

Sedentary lifestyle has become prevalent in our community. Recent data showed controversy on the effect of regular exercise on left ventricular compliance and myocardial relaxation.

Hypothesis

We sought to assess whether physical inactivity is an independent predictor of diastolic dysfunction in or community, after adjustment for several covariates.

Methods

Consecutive outpatients presenting to the echocardiography laboratory between July 2013 and June 2014 were prospectively enrolled. Clinical variables were collected prospectively at enrollment. Patients were considered physically active if they exercised regularly ≥3× a week, ≥30 minutes each time. The primary endpoint was presence of diastolic dysfunction.

Results

The final cohort included 1356 patients (mean age [SD] 52.9 [17.4] years, 51.3% female). Compared with physically active patients, the 1009 (74.4%) physically inactive patients were older, more often female, and had more comorbidities and worse diastolic function (51.3% vs 38.3%; P < 0.001). On univariate analysis, physical inactivity was associated with 70% increased odds of having diastolic dysfunction (odds ratio: 1.70, 95% confidence interval: 1.32‐2.18, P < 0.001). There was significant interaction between physical activity and left ventricular mass index (LVMI; P = 0.026). On multivariate analysis, patients who were physically inactive and had LVMI ≥ median had significantly higher odds of having diastolic dysfunction (odds ratio: 2.82, 95% confidence interval: 1.58‐5.05, P < 0.001).

Conclusions

In a large, prospectively enrolled cohort from a single tertiary center in the Middle East, physically inactive patients with increased LVMI had 2‐ to 3‐fold increased odds of having diastolic dysfunction after multivariate adjustment.
Sex disparities in use of chemotherapy and survival in patients with advanced bladder cancer
Authors: Rose Tracy L. , Deal Allison M. , Nielsen Matthew E. , Smith Angela B. , Milowsky Matthew I.
Published: May 2016

BACKGROUND

Women with advanced bladder cancer have inferior survival compared with men. However, women treated on clinical trials do not appear to have a survival disadvantage. Less frequent administration of systemic chemotherapy in women with advanced bladder cancer may contribute to their inferior survival.

METHODS

The authors identified patients diagnosed with stage IV bladder cancer from 1998 through 2010 using the National Cancer Data Base, a national outcomes database that includes 70% of all newly diagnosed cancer cases in the United States. Sex differences in demographics, systemic chemotherapy administration, and overall survival (OS) were compared.

RESULTS

A total of 23,981 patients were identified (35% of whom were female). Compared with men, women were older, more likely to be black, and less likely to be insured (P<.01 for all). The Charlson‐Deyo comorbidity score did not differ between men and women. Women were less likely to receive systemic chemotherapy than men (45% vs 52%; adjusted relative risk, 0.91 [95% confidence interval (95% CI), 0.88‐0.94]). Women had a lower median OS compared with men (8.0 months [95% CI, 7.7‐8.3 months] vs 9.8 months [95% CI, 9.5‐10.0 months]; P<.001). OS remained lower for women on multivariable analysis, even after adjusting for the administration of systemic chemotherapy (hazard ratio for death, 1.11 [95% CI, 1.08‐1.15]).

CONCLUSIONS

Women are less likely than men to receive systemic chemotherapy for advanced bladder cancer and this difference may partially account for the poorer OS observed in women. However, OS remains lower in women independent of chemotherapy use, and may be related to unmeasured comorbidities, functional status, or tumor biology. Cancer 2016;122:2012–20. © 2016 American Cancer Society.
Early impact of Medicare accountable care organizations on cancer surgery outcomes
Authors: Herrel Lindsey A. , Norton Edward C. , Hawken Scott R. , Ye Zaojun , Hollenbeck Brent K. , Miller David C.
Published: May 2016

BACKGROUND

Accountable care organizations (ACOs) were established to improve care and outcomes for beneficiaries requiring highly coordinated, complex care. The objective of this study was to evaluate the association between hospital ACO participation and the outcomes of major surgical oncology procedures.

METHODS

This was a retrospective cohort study of Medicare beneficiaries older than 65 years who were undergoing a major surgical resection for colorectal, bladder, esophageal, kidney, liver, ovarian, pancreatic, lung, or prostate cancer from 2011 through 2013. A difference‐in‐differences analysis was implemented to compare the postimplementation period (January 2013 through December 2013) with the baseline period (January 2011 through December 2012) to assess the impact of hospital ACO participation on 30‐day mortality, complications, readmissions, and length of stay (LOS).

RESULTS

Among 384,519 patients undergoing major cancer surgery at 106 ACO hospitals and 2561 control hospitals, this study found a 30‐day mortality rate of 3.4%, a readmission rate of 12.5%, a complication rate of 43.8%, and a prolonged LOS rate of 10.0% in control hospitals and similar rates in ACO hospitals. Secular trends were noted, with reductions in perioperative adverse events in control hospitals between the baseline and postimplementation periods: mortality (percentage‐point reduction, 0.1%; P = .19), readmissions (percentage‐point reduction, 0.4%; P = .001), complications (percentage‐point reduction, 1.0%; P < .001), and prolonged LOS (percentage‐point reduction, 1.1%; P < .001). After accounting for these secular trends, this study identified no significant effect of hospital participation in an ACO on the frequency of perioperative outcomes (difference‐in‐differences estimator P values, .24‐.72).

CONCLUSIONS

Early hospital participation in the Medicare Shared Savings Program ACO program was not associated with greater reductions in adverse perioperative outcomes for patients undergoing major cancer surgery in comparison with control hospitals. Cancer 2016. © 2016 American Cancer Society. Cancer 2016;122:2739–2746. © 2016 American Cancer Society.
Female rat transcriptome response to infraorbital nerve transection differs from that of males: RNA‐seq
Authors: Orczyk John J. , Batka Richard , Gore Ashleigh , Maio‐lexa Michelena , Kulkarni Akhil , Garraghty Preston E.
Published: May 2016

The effects of infraorbital nerve (ION) transection on gene expression in the adult female rat barrel cortex were investigated using RNA sequencing. After a 24‐hour survival duration, 28 genes were differentially regulated by ION transection. Differentially expressed genes suggest microglial activity, increased retrograde ciliary transport, and a decrease in inhibition. These changes may be functionally comparable to changes in the male barrel cortex, where changes in genes related to morphology, neuronal activity, and neuronal excitability were observed. However, the patterns in changes in gene expression are vastly different between male and female rats. The results strongly caution against the practice of generalizing data from one sex to both sexes. This cautionary note has potentially profound implications for a range of research lines, including substance abuse and stress, both research domains in which subjects have been predominantly males. Future research needs to employ sex as a classification variable, as sex differences can generally be expected. Future research is also needed to confirm that changes in gene expression observed with RNA‐seq correlate with changes in protein expression. J. Comp. Neurol. 525:140–150, 2017. © 2016 Wiley Periodicals, Inc.
Patterned Liposome–Polymer Composite Coatings
Authors: Zhang Yan , Lynge Martin E. , Nielsen Morten B. , Schattling Philipp S. , Han Xiaojun , Städler Brigitte
Published: May 2016

Engineered biointerfaces are crucial for many biomedical applications involving the interaction of (bio)materials with cells and tissue. Providing cues to support cell adhesion/proliferation in the form of biomolecules and/or by providing spatially controlled adhesive patches are important aspects. We demonstrate the assembly of composite films consisting of negatively charged liposomes (Ln), poly(dopamine) or cholesterol‐modified poly(methacrylic acid) (PMAc) capping layers and (poly(l‐lysine)/PMAc)x terminating multilayers. We show that hepatocytes adhere to the assembled composite coatings. Their association with fluorescent lipids from the film varies depending on the capping layer and cell adhesion time. This association was suggested to be an energy‐dependent process. Further, the incorporation of paclitaxel (TX) into Ln reduces the number of hepatocytes adhering to films without terminating multilayers. An exemplary composite coating is patterned, and the subsequent site‐selective adhesion of hepatocytes is shown. For the first time, composite coatings to be used for substrate‐mediated drug delivery with control over the positioning of the adhering cells are shown.
A Base‐Resistant ZnII‐Based Metal–Organic Framework: Synthesis, Structure, Postsynthetic Modification, and Gas Adsorption
Authors: He Tao , Zhang Yong‐Zheng , Wang Bin , Lv Xiu‐Liang , Xie Lin‐Hua , Li Jian‐Rong
Published: May 2016

A ZnII‐based metal–organic framework (MOF), [Zn2(bdp‐CHO)2]⋅(DMF)(CH3CN)(H2O)2 (BUT‐31) is reported that was synthesized by the reaction between a newly designed aldehyde‐tagged polypyrazole ligand 2,5‐di(1H‐pyrazol‐4‐yl)benzaldehyde (H2bdp‐CHO) and a zinc salt. BUT‐31 has a unique pillared layered framework structure with 3D intersecting channels approximately 3.4–5.4 Å in size. Powder X‐ray diffraction and N2 adsorption experiments revealed that BUT‐31 is rigid and permanently porous with the Brunauer–Emmett–Teller surface area of 926 m2 g−1. Notably, this MOF tolerates boiling water and even highly basic aqueous solution (4 m sodium hydroxide), although dilute acid gradually decomposes its framework. Owing the permanent porosity and chemical stability of BUT‐31, covalent post‐modification of the free aldehyde group exposed on the pore surface was accomplished by treating the MOF in a concentrated ammonia solution (25 %) at near room temperature, giving rise to an imine‐functionalized analogue of BUT‐31. Gas adsorption results show that the aldehyde‐ and imine‐functionalized MOFs have high CO2 adsorption capacities, as well as CO2/N2 and CO2/CH4 adsorption selectivities.