bluuebunny/crossref_metadata_2025 huggingface dataset:
Дистанционные образовательные технологии в обучении студентов медицинского института (на примере ФГАОУ ВО «СВФУ имени М.К. Аммосова»)
Authors: Карпова А.Г. , Протасова Н.А. , Бурцева А.А.
Published: June 2022

Дистанционное обучение - это новая форма обучения, которая несколько отличается от привычных форм обучения, таких как очная и заочная. Так как она предполагает другие методы, способы, средства, формы, иную форму взаимодействия педагога и учащихся, взаимодействия обучающихся между собой. Основной целью данного исследования является выявление значимости дистанционных образовательных технологий в обучении студентов медицинского института. Для достижения цели были поставлены следующие задачи: изучить дистанционные образовательные технологии по литературным источникам, проанализировать статистические данные мониторинга дисциплины «Первая помощь и уход за больными» в системе Moodle, провести анкетирование среди студентов для выявления значимости дистанционных образовательных технологий в обучении студентов медицинского института.
Модель подготовки учителя профессионального обучения
Authors: Курманбаев А.А. , Кабылов Е.Е. , Саят А.Ж.
Published: June 2022

В статье рассматривается вопрос теоретическое обоснование и практическая разработка содержания и методики формирования системы профессиональнотехнологических умений и навыков у будущих учителей профессионального обучения. Обосновано модель формирования профессионально - технологических умений и навыков у будущих учителей. Владение компетенцией как специалист способствует дальнейшему трудоустройству и конкурентоспособности специалистов в профессиональной деятельности.
Влияние плавания на тренировки и восстановление боксеров
Authors: Литвина Г.А. , Кульчицкий В.Е. , Сардаров Р.В.
Published: June 2022

Рассмотрена эффективность водных тренировок для боксѐров как для развития физических показателей, так и для восстановления после травм, а также классификация и виды занятий в воде.
К вопросу об интегрировании PhD программ в российскую систему высшего образования
Authors: Марьин Е.В.
Published: June 2022

В статье автор размышляет о возможностях и перспективах внедрения (искусственной трансплантации) в практику отечественного образования так называемых интегрированных PhD программ. Рассмотрены их сущность, показана их связь с американскими социальнокультурными условиями. В итоге делается вывод, о том, что возможно лишь частичное заимствование зарубежного опыта и его внедрение в практику подготовки магистрантов и аспирантов.
Взаимодействие социальных медиа в экономических отношениях и экономической безопасности
Authors: Агаширинова В.Ю.
Published: June 2022

В статье рассматриваются социальные медиа, которые помогают пользователям обмениваться информацией, защита информации.
Разработка антикризисных мер по обеспечению экономической безопасности предприятия (на примере ПАО «Трансконтейнер»)
Authors: Андреев В.А. , Рахматуллин Ю.Я.
Published: June 2022

Данная статья посвящена разработке антикризисных мер по обеспечению экономической безопасности предприятия. В настоящее время управление организациями происходит при неблагоприятных условиях, обусловленных новыми внешними и внутренними угрозами. На данный момент требуются разработки и реализации новых или адаптации существующих методов и способов решения экономических проблем.
Перспективы использования системы «директ-костинг» в управленческом учете организации
Authors: Боташева Л.С. , Лайпанова М.А.
Published: June 2022

В статье рассматривается перспектива внедрения модели «директ-костинг» в практическую деятельность организации. Метод директ костинга называют по-разному: калькуляция усеченной себестоимости, расчет переменных расходов, маржинальный учет затрат.
Efecto de rizobacterias solubilizadoras de calcio en caracteres agronómicos y minerales de Tagetes erecta
Authors: Ramos Salazar Raúl Alejandro , Mendoza-Villarreal Rosalinda , Robledo Torres Valentin , Hernández Pérez Armando
Published: June 2022

El objetivo del estudio fue evaluar tres rizobacterias silvestres (Bacillus sp, B. cereus y B. licheniformis) promotoras del crecimiento vegetal (PGPR) inoculadas de forma individual y combinadas sobre las propiedades agronómicas y calidad mineral de flor de cempasúchil en campo abierto. Se evaluaron ocho tratamientos: T0= testigo, T1= Bacillus sp., T2= B. cereus, T3= B. licheniformis, T4=Bacillus sp. + B. cereus, T5= Bacillus sp. + B. licheniformis, T6= B. cereus + B. lichenifomris, T7= Bacillus sp. + B. cereus + B. licheniformis, se aplicó  solución nutritiva Steiner sin Calcio. El experimento se estableció en bloques completos al azar con tres repeticiones por tratamiento. Los resultados mostraron que la biomasa fresca y seca de raíz se incrementó con la aplicación del tratamiento T6, la biomasa fresca y seca de follaje presentó mayores valores en T5, mismo tratamiento que incrementó los carotenoides totales (847.01 μg·g-1). En cuanto a minerales el calcio se concentró en hoja, en T2 y T1, el magnesio  en hoja en T7, en tallo el potasio en T5, el fósforo en pétalos en T5, en  hojas el nitrógeno, en T1 y T2. La aplicación de Bacillus es una alternativa para sustituir los fertilizantes cálcicos, lo que podría ayudar a mitigar los efectos negativos de una fertilización química.
The relationship of social media addiction and family climate of students of pharmacy faculty in the shade of COVID-19 pandemic
Authors: Buyukkayhan Derya , Yildirim Melis Seray Ozden
Published: June 2022

The COVID-19 pandemic has caused significant changes in everyone’s lives. Especially with the social isolation process, people have moved their entire lives to their homes. In this case, the use of the internet in connection with the outside world has brought an important point. This situation poses a risk for social media addiction for the future. On this basis the aim of this study is to investigate the relationship between social media addiction and family climate in the shade of COVID-19 pandemic. Besides, the social media addiction was studied according to demographical features as the subgoals of the study. The research group was conducted by 364 university students of pharmacy faculty. Data was collected with Demographical Information Form, Social Media Addiction Scale and Family Climate Scale. The results showed that there were negative correlations found between social media addiction and cognitive cohesion subdimension of family climate. And only cognitive cohesion predicted social media addiction significantly. Also the findings indicated that the using ratios of social media accounts during the pandemic period were increased significantly. As a result of the study, the family relationships of the students were also examined within the scope of the pandemic period and their relationship with social media addiction was emphasized.

 

Keywords: Pandemic; Covid-19; family climate; social media addiction
Desradicalización y desvinculación: aspectos formales y teóricos
Authors: Lobato Roberto M. , García-Coll Josep
Published: June 2022

Radicalization is currently one of the biggest social and security challenges. Nonetheless, the increase in arrests that has taken place the last years has moved the focus towards deradicalization and disengagement processes. In an attempt to converge academic knowledge on the topic, this article provides a literature review where relevant deradicalization, disengagement, and rehabilitation factors and models are identified and evaluated. Initially, the article will conceptualize deradicalization, understood as a social and psychological process in which individuals engaged actively in violent radicalization reduce their commitment to the cause, up to the point there is no risk of supporting and participating in violent activities. Then, it will differentiate disengagement as the process by which individuals change their role or function in a way that reduces their participation in violence. Afterwards, the main deradicalization push and pull factors will be analyzed, highlighting, on the one hand, disappointment with the strategy or actions of the radical group and, on the other hand, external relationships and family commitments. Subsequently, seven theoretical models from different disciplines are described, which explain disengagement, deradicalization and rehabilitation. Amongst the models, we find the six-phase disengagement trajectory, the investment model, the 3N model, the pro-integration model, the reinforcement loops model, the disengagement dynamics model, and the phoenix disengagement model. Finally, similarities and differences, and limitations of these models are discussed.
KARAKTERISTIK ORGANOLEPTIK, KIMIA, DAN TOTAL MIKROBA PINDANG IKAN TONGKOL TERAWETKAN GARAM DAN SERBUK BIJI PICUNG (Pangium edule Reinw) SELAMA PENYIMPANAN
Authors: Arista Yuvita Lira Vesti , Witono Yuli , Fauzi Mukhammad
Published: June 2022

Picung (Pangium edule Reinw) seeds had been used as fresh fish preservatives for a long time, there had not been reported about the boiled salted tuna using picung seeds. The aim of this research was to determine the chemical organoleptic properties and total microbe of boiled salted tuna with the addition of salt and picung seed powder during storage. This research consisted of 2 factors, those were variations of the salt concentration which consisted of G1 (the use of 10% of salt), G2 (the use of 15% of salt), and G3 (the use of 20% of salt) and the variations of picung seeds powder which consisted of P1 by adding 1% of picung seeds powder (150-200 g of the fish weight), P2 by adding 3%, and P3 by adding 5%. It was done three times. The organoleptic, chemical, and total plate count (TPC) of boiled salted tuna observation was done during 0, 3, 6, and 9 days of storage. The organoleptic test of boiled salted tuna by using 20 persons of the untrained panelists (permanent respondents). The organoleptic observation parameters consisted of appearance, aroma, taste, and mucous. The result of boiled salted tuna which used 15% (G15) and 20% (G20) of salt and added 3% (P3) and 5% (P5) of picung seeds powder could be still accepted by the panelist until in day-9. In addition, it was also able to maintain chemical properties up to day-6 of storage including parameters of free fatty acid and TVBN (total volatile basic nitrogen) content. The use of salt and powdered picung seeds with a ratio of 15%:5% (G15P5) and 20%:5% (G20P5) was able to maintain the amount of TPC until the day-6 of storage not to exceed the specified threshold.

Keywords: boiled salted tuna, organoleptic, TPC, TVBN
Kadłubek. Zaślubiny żalu i wesołości. Część pierwsza
Authors: Żarowski Mirosław Jan
Published: June 2022

In the present monography I attempt to present The Polish Chronicle by Master Wincenty, named Kadłubek, as a philosophical work, in accordance with the 12th century patterns of understanding historiographical and philosophical tasks. I begin with Kadłubek’s biography, treating it as the expression of a lifelong commitment of the writer in the light of documents, signatures and insignia of his being the master. Exposition of a structure and a facture of the work offers a chance to consider the issue of the dialogical character of The Polish Chronicle and its intertextuality. On the one hand, philosophical quotations and borrowings are subject almost entirely to the demands of a narrative, or within the horizon of characteristic/typical writing of that time, which consisted in the culture of subtle compilation. Originality was treated at that time not as a manifestation of authorial novelty, but as a stoppage close to original sources. The study of Prologue confronts itself with the trial to understand how in the preface (which is seeking a pretext and a way of introducing itself), genological features and elementary references of historical work, hung according to classical poetics between prose and poetry, in confrontation with its theatrical character and theatrical character of the world itself, making the issue of authorship more complicated, establishing an auditory and satisfying communicational situation, which enables the coming together of the living and the dead. Following the dictate of the original text themes, of historical times and time in general, subjectivity, identity, testimony, benevolence, reflection, creation of the world and the establishment of justice are considered in the subsequent chapters and subchapters of part two. Their purpose is to resist the unfounded status of the messages postulated by the Wincenty community, of those who live and those who are dead, as well as about the ever deeper relations between The Polish Chronicle and Plato’s Timaeus. These messages are profoundly grounded. The dispute about the right to mourn appears to be the essence of conflict that has been tearing, since the beginning, Polish Res Publica, the history of which Kadłubek describes.
Dialogic Feed-Forward in Assessment: Pivotal to Learning but not Unproblematic
Authors: Hill Jennifer , West Harry
Published: June 2022

A key debate in higher education is how assessment and feedback can be constructed to maximize opportunities for meaningful student learning. In this paper, we explore how a learning-focused model of feedback, teacher-student dialogic feed-forward, is enacted in practice, exposing many affordances but also some challenges. Adopting a small-scale intensive approach, we trace the learning journeys of four students through a second-year undergraduate unit at a British university and on into their third and final year of study, accessing verbal testimony, teacher written comments on draft and final summative coursework, and student performance within and beyond the unit. We present in-depth student responses, understanding, behaviours, and achievement with respect to the feed-forward dialogue, revealing the subtleties of their reactions. Our findings evidence the transformative power of assessment dialogue on student learning for a range of achievers. Dialogic feed-forward can act as a pivotal moment in learning, where students reflect on their work, judge their standards against criteria, and co-create positive actions for improvement. Students develop cognitively, meta-cognitively, and affectively, becoming more comfortable with challenge and more productive in their learning. We conclude by widening our frame of reference to problematize dialogic feed-forward within current debates about higher education pedagogy.
Letting Go of Grades: Creating an Environment of Autonomy and a Focus on Learning for High Achieving Students
Authors: Hall Eric , Meinking Kristina
Published: June 2022

In this essay we discuss an iterative, reflective writing assignment (the “learning charter”) as a way to understand how high-achieving students experienced an ungrading learning environment. Working with evidence from student written reflection and in-class conversations, we chronicle how students articulated their perspectives on this approach through the fifteen-week semester. Our findings indicate that despite initial uncertainty, students found the environment to be one that promoted learning for the sake of learning, cultivated mental wellness, and compelled them to pursue meaningful questions about their own educational goals and experience. While this development was not without feelings of conflict and struggle throughout the course, by the end of it, students reported a renewed focus on the value of learning. We suggest that the strategies employed in this course might be successfully adopted in or adapted to other courses for high-achieving students, as well as other student populations.
Human Rights and International Trade: How does the Trade System Violate Human Rights under the COVID-19 Pandemic?
Authors: Wan Hui
Published: June 2022

Under COVID-19, the free trade system, especially the global intellectual property regime, is violating human rights in new ways. In the current fragmented state of international health law and human rights law, intellectual property law under the global trading system is commoditizing COVID-19 vaccines and other essential medicines, prioritizing commercial interests and patent protection over human rights. Although the international human rights system has issued a number of resolutions and reports on this issue, and many international and national organizations have also introduced mechanisms similar to the COVAX plan, the situation of "vaccine apartheid" and the marginalization of the interests of people in poor areas still exists. Therefore, this paper proposes some initial recommendations for better safeguarding of human rights during the COVID-19 outbreak, such as strengthening international cooperation or highlighting the human rights responsibilities of non-state actors, including multinational corporations and NGOs.
DIGITAL MARKETING FOR ACCOMMODATION SERVICE BUSINESSES IN BAWEAN ISLAND, GRESIK
Authors: Reindrawati Dian Yulie , Nata Jiwangga H , Bascha Umi F , Suriani Nur E
Published: June 2022

Background: The success of developing a tourist village starts from the accommodation manager at a tourist site and depends on the level of acceptance and support of the local community. Local communities will later act as hosts and become important actors in the development of tourist villages in all stages, starting from planning, monitoring, and implementation so that their success will also be enjoyed with a multiplier effect on the surrounding community. However, tourists often do not get information because of the lack of promotion in the media about the condition of the tourist area and also the readiness of accommodation. Objective: To provide digital marketing training for accommodation service businesses on Bawean Island. Methods: The method used is training and mentoring related to what digital marketing is, the urgency of using digital marketing, how to compose interesting content, execution of social media usage and also making attractive social media layouts. Results: The result of this activity is the implementation of digital marketing in the partner accommodation business. This activity was also accompanied by the creation of a film concept about the activities of the community community in Bawean Island which was accurate. Conclusion: the community, in this case the business actors, is still traditional. They still really need information and knowledge about digital marketing promotion efforts. Therefore, this tourism training activity is important so that the knowledge and skills of the tourism business community will increase.
EMPOWERMENT OF YOUTH COMMUNITY IN POSO REGENCY, THROUGH PRODUCE TOMATO AND MELON BY HYDROPONIC SYSTEM
Authors: Manuhara Yosephine Sri Wulan , Novi Kristanti Alfinda , Sugiharto Sugiharto , Sugiarso R. Djarot , Kartjito Putro Yohanes , Wal Yudha Arga
Published: June 2022

Background: Tentena City is one of the tourist centers with rapid economic growth located in Poso Regency because Poso Lake is very famous and able to change the economic level of the community. But there are still 20% of people who live very poor and 60% of the lower middle class and the remaining 20% of the middle to upper middle. Through the youth community Pukat Tentena is expected to foster and encourage millennials to develop vegetable and fruit entrepreneurs using more modern cultivation techniques. Objectives: empowering the youth community in Tentena city, Pamona Puselemba Subdistrict, Poso Regency, Central Sulawesi with entrepreneurial tomato fruit products and melons produced by hyrdoponik drip irrigation system. Methods: This community service activity was carried out in Tentena village, Pamona Puselemba Subdistrict, Poso Regency, Central Sulawesi Province with TENTENA PUKAT Youth Community partners starting from May to September 2021. Results: Mitra has successfully cultivated tomato and melon plants with hydroponic drip irrigation system techniques in green houses until they are obtained salesable results. The average number of tomatoes per stalk is 4.05 and the average fruit diameter is 5.1 cm; While the average weight of melons is 1.2 -1.8 kg. Conclusion: The results of this community service activity provide benefits for partners, namely providing additional knowledge about how to cultivate tomatoes and melons with hydroponic drip irrigation system techniques and increase partner income by selling tomatoes and melons from hydroponic cultivation.
Quando objetos ganham voz: o curso de Museologia da UFRGS pelas relações de afeto produzidas na vivência universitária
Authors: Faria Ana Carolina Gelmini de , Pereira Eráclito
Published: June 2022

O programa de extensão Museologia na UFRGS: trajetórias e memórias preserva e investiga o itinerário da Museologia na referida universidade, com ações de salvaguarda e comunicação voltadas para a preservação desse recorte da História da Educação. A pandemia da Codiv-19 estimulou a equipe a executar estratégias de vínculo identitário no decorrer do isolamento social. Uma das propostas foi a elaboração da subcoleção Afetividades Sonoras, que tem por objetivo coletar narrativas orais vinculadas ao patrimônio histórico-educativo pela perspectiva dos sujeitos envolvidos. A iniciativa estimula a partilha de experiências que a dimensão material não contempla isoladamente. Esse processo valoriza as pessoas e suas relações, estas mediadas pelos objetos.
Understanding Opportunities for Urban Forest Expansion to Inform Goals: Working Toward a Virtuous Cycle in New York City
Authors: Treglia Michael L. , Piland Natalia C. , Leu Karen , Van Slooten Alaina , Maxwell Emily Nobel
Published: June 2022

Urban forests are critical infrastructure for mitigating environmental and social challenges cities face. Municipalities and non-governmental entities, among others, often set goals (e.g., tree planting or canopy targets) to support urban forests and their benefits. We focus on canopy goals and develop conceptual underpinnings for an analysis of where additional canopy, as one important dimension of the urban forest, can fit within the landscape, while considering factors that influence where trees can be planted and where canopy can grow – ‘practical canopy.’ We apply this in New York City (NYC) to inform the setting of a canopy goal by the NYC Urban Forest Task Force (UFTF) for the NYC Urban Forest Agenda, which may trigger a virtuous cycle that supports the urban forest there. We further develop framing for a ‘priority canopy’ analysis to understand where urban forest expansion should be prioritized given more context (e.g., environmental hazards, local preferences), which can inform how expansion of the urban forest is achieved. We estimate an opportunity for 15,899 ha of new canopy in NYC given existing opportunities and constraints (practical canopy), which, if leveraged, could result in nearly doubling the canopy as of 2017 (17,253 ha). However, like existing canopy, practical canopy is not evenly distributed, in general, or across jurisdictions and land uses. Relying solely on areas identified as practical canopy to expand the urban forest would exacerbate inequities in its distribution. We discuss how the NYC UFTF established an aspirational but achievable goal of 30% canopy cover by 2035, which was informed by this analysis and guided by priorities of equity, health, and resilience. Achievement of this goal will ultimately require a combination of protecting and stewarding the existing resource, and leveraging opportunities for tree planting. Achieving a more equitable urban forest will also require identification of priority canopy, and, in cases, creation of new opportunities for tree planting and canopy expansion. Overall, the collaborative establishment of such goals based on local context can be instrumental in creating a virtuous cycle, moving conservation actors toward exercising influence and agency within the social ecological system.
Neuropsychological Findings in Adults with Triple X Syndrome
Authors: Otter Maarten , Campforts Bea , Stumpel Connie TRM , Van Amelsvoort Thérèse , Vingerhoets Claudia , Drukker Marjan
Published: June 2022

Triple X syndrome (TXS, also known as trisomy X or 47,XXX) has been associated with impaired overall neurocognitive functioning in children and relatively young adults. However, neurocognitive functioning in adults with TXS is poorly understood. The aim of this study was, therefore, to examine cognitive functioning in adults with TXS. Methods: In this cross-sectional study, data were collected from 34 adult women with TXS (mean age = 32.9; SD = 13.1) and 31 controls (mean age = 34.9; SD = 13.7). General intellectual functioning, semantic/verbal memory, visual/episodic memory, psychomotor speed, and attention and executive functioning were then compared between these two groups. Results: We found that general intellectual functioning was significantly lower in the TXS group compared to the control group. In addition, women with TXS had more attention problems and lower psychomotor speed, particularly motor processing speed. When the analyses were adjusted for IQ, the strength of these associations decreased. The women in the TXS group also scored significantly lower at free recall in the verbal memory test, but not in immediate or delayed recognition. Finally, visual/episodic memory and executive functioning did not differ significantly between groups. Conclusions: Our analysis revealed that women with TXS score lower in general intellectual functioning and have impairments in motor processing speed and attention compared to controls, but do not differ with respect to executive functioning. These results offer new insights for improving the support of adults with TXS both at school and in the workplace.
Correction of the State of Enamel Mineral Metabolism in Persons with Decompensated Caries at Various Times after Oral Cavity Sanitation
Authors: Shumilovich B , Sushchenko A , Podoprigora A , Shishkin D , Burykh R , Kunin V , Evtukova M , Daulech K
Published: June 2022

The aim of the study was to determine the effectiveness of brushite exposure to correct the marginal permeability of composite restorations in persons with a decompensated form of carious process activity; this study also examined the penetrating ability of brushite in the micro-cracks of the enamel-composite border Methods and Results: The study included 120 patients (age 18-40 years) with a decompensated course of the carious process, who underwent complete oral cavity sanitation with the direct composite restoration of 300 teeth. The obtained results were analyzed and interpreted in vivo (the clinical effectiveness of the restoration was assessed according to the Ryge criteria immediately after treatment and 1, 12, and 36 months after treatment) and in vitro (scanning electron microscopy of the enamel-composite joint after applying the composite and after treatment with the studied means). According to the purpose and objectives of the study, two groups of patients were formed: Group 1 (control, n=58): the prevention of recurrent caries after sanitation was carried out using a standard personal hygiene product containing fluorine; Group 2 (experimental, n=62): the prevention of recurrent caries after sanitation was carried out using a natural two-component complex for strengthening and remineralization of enamel RemarsGel. During statistical processing of the obtained data, immediately after sanitation and one month after it, the differences in the indicators of the Ryge criteria in Groups 1 and 2 were statistically insignificant. Twelve months after the sanitation, the Ryge restoration quality indicators in Group 2 were higher than in Group 1 (P≤0.001). After 36 months, the statistical significance of the difference in the restoration quality indicators increased (P≤0.0001). These results were confirmed by the data of scanning electron microscopy. Based on the results obtained, stating the state of the quality of the enamel-composite joint, it can be concluded that brushite crystals are highly effective in preventing violations of the integrity of the enamel-composite joint, which has a direct and immediate impact on the quality of restoration. Conclusion: We consider it necessary to add to the list of main indications for the use of the RemarsGel system one more, a scientifically based indication of the targeted use of the system in the presence of a significant amount of adhesive, both direct and indirect restorations in the oral cavity, especially in the decompensated course of the carious process.
sST2 Level at Decompensated Chronic Heart Failure in Patients with Dilated Cardiomyopathy
Authors: Gulomov Khumoyun A , Abdullaev Timur A , Tsoi Igor A , Ziyaeva Adolat V
Published: June 2022

The purpose of the study was to evaluate the relationship between clinical and functional changes and sST2 levels in patients with dilated cardiomyopathy (DCM) admitted to the hospital due to decompensated chronic heart failure (CHF). Methods and Results: The study involved 64 DCM patients with clinical signs of decompensated CHF. According to the sST2 level, the patients were divided into two groups. Group 1 included 30 patients with sST2 level <35ng/ml; Group 2 included 34 patients with sST2 level ≥35ng/ml. All patients underwent the following examinations: collection of anamnestic data, physical examination, general clinical and laboratory blood tests, 12-lead ECG, conventional 2D echocardiography in M- and B-modes, the 6MWT, and the assessment of the quality of life according to the Minnesota Living with Heart Failure Questionnaire (MLHFQ). The serum level of sST2 was determined by enzyme immunoassay using the Presage ST2 Assay. The duration of CHF was significantly longer in Group 2 than in Group 1(48.7±6.5 mth versus 29.6±7 mth P<0.05), and the number of hospitalizations per year was more frequent. Group 2 patients were characterized by lower blood pressure levels and high heart rate (P<0.05). At the same time, the 6MWT value was lower and MLHFQ score was higher in Group 2 than in Group 1 (P<0.001 in both cases). In Group 1, LVEF was significantly higher and LVM was significantly lower than in Group 2 (P<0.001). All in all, Group 2 patients had more pronounced disorders in LV systolic dysfunction. The correlation analysis revealed an inverse correlation between the sST2 level and 6MWT (r=-0.69, P<0.01), as well as LVEF (r=-0.26, P<0.01). Statistically significant direct correlations were found between the sST2evel and the size and volume of the LV cavities. Conclusion: sST2 is a clinically relevant biomarker that reflects pathophysiological processes and provides prognostic information in the setting of DCM, especially in patients with HF.
The Association of C-Reactive Protein and Ferritin Levels with the Severity of COVID-19 in Ajman, UAE
Authors: Obaid Khulood Ghanim , Hussein Salah Eldin Omar , Osman Ahmed L , Abdmomen Noha Kamal , Ismail Marwan , Kandakurti Praveen Kumar , Altoum Abdelgadir Alamin
Published: June 2022

Background: SARS-Cov-2, a new strain of coronavirus first identified in Wuhan city, China, has spread worldwide, causing severe illnesses and a high mortality rate. Many studies have shown the association of elevated levels of pro-inflammatory markers, such as ferritin and C-reactive protein (CRP), with the severe course of coronavirus disease The aim of this research was to investigate the association between CRP and ferritin levels, and the severity of COVID-19. Methods and Results: This cross-sectional study was performed in Thumbay Hospital, Ajman, United Arab Emirates, from January 2021 to October 2021. A total of 100 COVID-19 positive patients were included in this study. Serum CRP and ferritin were measured by immunoturbidimetric assay. We found statistically significant differences between ferritin levels and disease severity (P=0.005), age category (P=0.030), and the clinical wards (P=0.016). Statistically significant differences were found between the ferritin levels in mild to moderate cases (P=0.023) and mild to severe cases (P=0.007). There were significant differences in CRP in mild to moderate cases (P=0.012), and in mild to severe cases (P=0.000). Thus, the results obtained showed that CRP and ferritin levels are considerably greater in severe cases than in mild and moderate cases of COVID-19. The findings of the current study indicate that CRP and serum ferritin levels might be considered as an essential indication of the progression and severity of COVID-19.
Updates on Hirsutism: A Narrative Review
Authors: Hussein Ramadan S , Abdelbasset Walid Kamal
Published: June 2022

Hirsutism is described as an abnormal amount of hair development in females in a male-like way. Excessive hair growth is frequently associated with severe emotional discomfort. Hirsutism is a frequent presentation to dermatologists, as women seek both aesthetic and therapeutic treatment options for their condition. Hirsutism is caused by an excess of androgens, most frequently from the ovary or adrenal glands. Hirsutism is frequently linked with metabolic disorders such as polycystic ovary syndrome (PCOS); it can also occur idiopathically, as a side effect of medicine, or, rarely, due to a serious underlying condition. This article discusses the diagnosis and treatment of hirsutism concisely.
An Overview of Diagnosis and Treatment of Melasma
Authors: Hussein Ramadan S , Abdelbasset Walid Kamal
Published: June 2022

Melasma is a persistent hyperpigmentation condition that is most commonly seen in middle-aged women. The malar, central, and mandibular parts of the face are most affected by this condition, Factors that contribute to melasma's etiology are still a mystery. Multifactorial causes are now widely accepted in these cases. In order to diagnose melasma and its variants, distinguish them from other pigmented illnesses, and keep track of treatment progress and side effects, several diagnostic tools are employed. The limited response and high recurrence rate make treating melasma difficult. Melasma can be treated with a variety of methods, including topical medicines, laser treatment, and injections. The objective of this article is to offer a concise overview of melasma diagnosis and management.
O orientador como mediador de letramento privilegiado no processo de escrita da tese de doutorandos
Authors: Paris Larissa Giacometti
Published: June 2022

O objetivo deste artigo é analisar o modo como se constituem as relações de quatro doutorandos da UNICAMP, pertencentes a diferentes áreas de conhecimento, com seus respectivos orientadores durante o processo de escrita da tese. Para tal, o trabalho fundamenta-se nos princípios teórico-metodológicos dos Letramentos Acadêmicos e da etnografia da linguagem. No contexto desta pesquisa, os orientadores são considerados mediadores de letramento privilegiados. Os dados revelam a natureza das relações de poder instauradas nas interações entre doutorandos e seus orientadores, além do descompasso entre as expectativas criadas pelos participantes e o que de fato se concretizou na relação construída entre orientandos e orientadores. Este artigo, portanto, aponta para a necessidade de implementação de políticas institucionais que promovam uma formação para os orientadores com base na perspectiva dos Letramentos Acadêmicos.
Olhando o passado para conhecer o presente da macrotoponímia municipal de Alagoas
Authors: Melo Pedro Antonio Gomes de , Lima Karollyny de Araújo
Published: June 2022

Este artigo objetiva apresentar uma descrição dos processos de mudanças na macronomenclatura municipal alagoana, desde a sua origem (denominação inicial dos futuros municípios) até a institucionalização do macrotopônimo atual (oficialização do nome do município emancipado). Quanto aos pressupostos teóricos, filia-se, em linhas gerais, ao campo da Onomástica, em especial ao modelo taxionômico toponomástico de Dick (1990) e, no campo da categorização das mudanças toponímicas, adota o modelo de tipificação das mudanças toponímicas proposto por Melo (2018). Metodologicamente, configura-se como uma pesquisa do tipo bibliográfico e documental de abordagem quali-quantitativa. Os resultados revelaram que, dos 102 nomes atribuídos aos municípios alagoanos, 34 nomes não foram afetados pela dinâmica de mudança toponímica durante o processo de institucionalização do macrotopônimo atual e oficial, já 68 nomes de municípios, em Alagoas, foram substituídos ou sofreram algum tipo de alteração em suas formas, sendo registrados 45 casos de mudanças totais, 19 de mudanças parciais e 04 de mudanças aparentes. Nessa dinâmica de mudança, identificou-se 22 mudanças espontâneas e 46 mudanças sistemáticas no corpus analisado. Como conclusão, aponta-se que o marco temporal, os elementos de constituição geoespacial das terras alagoanas e os aspectos socioculturais condicionaram as mudanças toponímicas.
Recursos léxico-gramaticais no ensino da língua portuguesa
Authors: Gil Beatriz Daruj
Published: June 2022

Para que o ensino do léxico seja mais profícuo, recomenda-se que a unidade lexical atualizada nos textos seja considerada em uma perspectiva pluridimensional que envolva não apenas seu conteúdo semântico, mas o gramatical e o discursivo (RICHARDS, 1976; NATION, 1990, 2005; SCHMITT, 2010). Tendo como base os planos da gramática e da significação lexical, correspondentes ao nível do sistema, da norma e do discurso, apresenta-se, neste artigo, uma reflexão sobre como tratar o léxico em sua articulação com a gramática nas aulas de língua portuguesa, com ênfase à exploração dos recursos linguísticos selecionados a cada enunciação, seguida de uma proposta de atividade para o ensino de português, cujo objetivo é ressaltar a importância de práticas epilinguísticas para o desenvolvimento do saber léxico-gramatical.
Impact of hyperbilirubinemia associated acute kidney injury on chronic kidney disease after aortic arch surgery: a retrospective study with follow-up of 1 year
Authors: Lyu Lin , Song Haicheng , Gao Guodong , Dong He , Liao Pingping , Shen Ziying , Liu Hui , Chu Haichen , Yuan Li
Published: June 2022

Background: Hyperbilirubinemia (HB) is a serious complication in aortic arch surgery, which is associated with acute kidney injury (AKI). The association between HB and chronic kidney disease (CKD) is unknown. The aim of this study was to investigate the impact of HB associated AKI on CKD after aortic arch surgery.Methods: We reviewed 284 patients who underwent aortic arch surgery from 2016 to 2020 in our hospital. AKI was defined as a 50% increase in sCr from baseline value within the first 7 postoperative days. HB was defined as total bilirubin >51.3 μmol/L. Patients were divided into 3 groups based on AKI and HB: HB associated AKI (HB-AKI) group (AKI patients suffered HB within the first 7 postoperative days); AKI without HB group and Non-AKI group. Results: Follow-up for 204 patients ranged from 3 to 12 months. Kaplan–Meier analysis showed that the 1-year cumulative incidence of CKD was highest in HB-AKI (32.6%) than AKI without HB (17.8%) and Non-AKI (7.4%, log-rank test, p<0.001), and the incidence of CKD was higher in HB group than that in Non-HB group (26.7% vs. 13.9%, log-rank test, p=0.015). Preoperative sCr (HR 1.010, 95% CI 1.004-1.016，p=0.001), AKI without HB (HR 2.887, 95% CI 1.133-7.354, p=0.026) and HB-AKI (HR 4.490, 95% CI 1.59-12.933, p=0.005) were associated with CKD during 1-year follow-up.Conclusions: Patients suffering HB associated AKI were at more increased odds of CKD than patients suffering AKI without HB after aortic arch surgery.
Thromboembolic and hemorrhagic complications in patients with prosthetic heart valves: 15-years of experience at a third level care center. What have we learned?
Authors: Medina Fernando Fabián Sánchez , Valenzuela-Antelo Olivia , Valenzuela-Molina Lucía Concepción , Arias-Martínez Joel , López-Morales Cruz Mónica , Ornelas-Aguirre José Manuel
Published: June 2022

Background
Valve replacement surgery with mechanical or biological prostheses is associated with a risk of thromboembolism and hemorrhagic complications related to complementary anticoagulation therapy. Current American and European treatment guidelines have established recommendations for the choice of heart valve prosthesis and the corresponding optimal anticoagulation therapy. The present study focuses on the presence of the abovementioned complications as well as on determining the probability of their risk.
Methods
We studied a cohort of 163 patients who underwent valve replacement surgery from 2002 to 2016 with either mechanical or biological prostheses. Both groups were treated with vitamin K agonist (VKA) complementary anticoagulation therapy after hospital discharge. Anticoagulation therapy was categorized into either optimal or not optimal according to the international normalized ratio (INR) values prior to the development of complications. Patients with comorbidities and other risk factors for thrombosis and/or bleeding were excluded.
Results
A total of 68.7% of patients underwent valve replacement with a mechanical prosthesis, and 31.3% were subjected to valve replacement with a biological prosthesis (p ≤ 0.001). Of those who received mechanical prostheses, 72.3% were younger than 60 years, and 27.7% were older than 60 years (p ≤ 0.001). Twenty-five percent of the patients had complications during the study (p ≤ 0.001), but their incidence was not associated with age (68.3% ≤ 60 years; p = 0.59). Hemorrhagic complications were the most common, observed in 48.8% of patients, followed by thromboembolic complications, seen in 26.8% of patients; both types of complications were noted in 24.4% of patients (RR 4.229 [CI 1.122-15.933]). Of the patients with complications, 95.1% received mechanical prostheses, and 4.9% received biological prostheses (p = 0.005). Among all patients who received prostheses, 49.7% had a nonoptimal INR; of these patients, 88.9%, had mechanical prostheses and 11.1% had biological prostheses (p ≤ 0.001).
Conclusions
Because of the high risk of thromboembolic and hemorrhagic complications, valve prostheses should be chosen carefully, and the priority of care should include prevention and follow-up, primarily for in patients requiring anticoagulation therapy.
Profiling the neurovascular unit unveils detrimental effects of osteopontin on the blood-brain barrier in acute ischemic stroke
Authors: Spitzer Daniel , Guérit Sylvaine , Pütz Tim , Khel Maryam Ibrahim , Armbrust Moritz , Dunst Maika , Macas Jadranka , Zinke Jenny , Devraj Gayatri , Jia Xiaoxiong , Croll Florian , Sommer Kathleen , Filipski Katharina , Freiman Thomas , Looso Mario , Günther Stefan , Tacchio Mariangela Di , Plate Karl Heinz , Reiss Yvonne , Liebner Stefan , Harter Patrick Nicholas , Devraj Kavi
Published: June 2022

Blood-brain barrier (BBB) dysfunction, characterized by degradation of BBB junctional proteins and increased permeability, is a crucial pathophysiological feature of acute ischemic stroke. Dysregulation of multiple neurovascular unit (NVU) cell types is involved in BBB breakdown in ischemic stroke that may be further aggravated by reperfusion therapy. Therefore, therapeutic co-targeting of dysregulated NVU cell types in acute ischemic stroke constitutes a promising strategy to preserve BBB function and improve clinical outcome. However, methods for simultaneous isolation of multiple NVU cell types from the same diseased central nervous system (CNS) tissue, crucial for the identification of therapeutic targets in dysregulated NVU cells, are lacking. Here, we present the EPAM-ia method, that facilitates simultaneous isolation and analysis of the major NVU cell types (endothelial cells, pericytes, astrocytes and microglia) for the identification of therapeutic targets in dysregulated NVU cells to improve the BBB function. Applying this method, we obtained a high yield of pure NVU cells from murine ischemic brain tissue, and generated a valuable NVU transcriptome database (bioinformatics.mpi-bn.mpg.de/SGD_Stroke). Dissection of the NVU transcriptome revealed Spp1, encoding for osteopontin, to be highly upregulated in all NVU cells 24 hours after ischemic stroke. Upregulation of osteopontin was confirmed in stroke patients by immunostaining, which was comparable with that in mice. Therapeutic targeting by subcutaneous injection of an anti-osteopontin antibody post ischemic stroke in mice resulted in neutralization of osteopontin expression in the NVU cell types investigated. Apart from attenuated glial activation, osteopontin neutralization was associated with BBB preservation along with decreased brain edema and reduced risk for hemorrhagic transformation, resulting in improved neurological outcome and survival. This was supported by BBB-impairing effects of osteopontin in vitro. The clinical significance of these findings is that anti-osteopontin antibody therapy might augment current approved reperfusion therapies in acute ischemic stroke by minimizing deleterious effects of ischemia-induced BBB disruption.
Effects of Furfural residues on community composition and diversity of rhizosphere microbe of seed production
Authors: Zhao Yunchen , Chen Guangquan , Yan Zhibin , Wang Zhijiang , Xiao Rang , Fu Wenjiang
Published: June 2022

The influence of furfural residue on rhizosphere microbiota of corn seed production after long-term cropping were studied by high-throughput sequencing and field plots. The results showed that soil of unplanted, chemical fertilizer (only) application, furfural residue application, and seasonal soil batches recruited distinct rhizosphere microbiota. The microbial community diversity and OTUs increased compared with that of unplanted soil. With exception of Ascomycota, maize plants grown under field conditions were preferentially colonized by Zygomycota in unplanted soil, Mortierellomycota in chemical fertilizer-only soil, while Basidiomycota in frufural residue-treated soil. Potential pathogens as Alternaria, Trichocladium, Bipolaris etc. were not detected, while beneficial microbes as Penicillium, Schizothecium and Rhizophlyctis were presented. Acidobacteria and Bacteroidetes increased, and Actinobacteria and Firmicutes decreased in furfural residue application. The core bacteria after long-term continuous cropping were MND1, RB41, Nitrospira, Cellvibrio, Adhaeribacter etc. The relative abundances of Clostridium, Pseudarthrobacter and Roseiflexus decreased; Haliangium, Nitrospira and MND1 increased; and Pirellula, Ellin6067 and Luteimonas reduced in different seasonal soil batches. Amendment with furfural residue promoted the development of beneficial microbes and decreased the relative abundance of pathogens. Also, the amendment increased cellulose- degrading and complex carbon-decomposing microbes, decreased the number of reductive substance- decomposing microbes, which led to a shift in microbial community structure over time and improved the rhizosphere environment. Furfural residue can be used as a soil amendment to relieve soil-borne diseases and to establish beneficial soil microbes.
Rapid epidemic expansion of the SARS-CoV-2 Omicron BA.2 subvariant during China’s largest outbreaks
Authors: Dai Dr. Yeyu Freddie
Published: June 2022

A complete and accurate statistical analysis of cases of contraction with SARS-CoV-2, under the conditions of strict mandatory quarantine and isolation and of a high rate of full vaccination, during the largest COVID-19 outbreaks driven by the Omicron BA.2 subvariant in China are given. SARS-CoV-2 is still new, and little is known about either its directions of variations or its laws of propagation. No country other than China has been able to disclose every case of infection in every epidemic or outbreak since April of 2020. Here, this study reveals that Omicron BA.2 subvariant can still spread very fast and wide in areas with strict “dynamic zero-COVID strategy”1 in China, that there exist cities twenty-fold differences in morbidity rates unrelated to any of the known factors contributing to incidence of infectious diseases, and that Omicron BA.2 subvariant is unpredictable in its virulence, although its severity rate of symptomatic cases is low. This analysis provides first-hand original and valuable information for further research on similar epidemics in the future. It may bring new thoughts for correction of present epidemiological theory and mathematical models. It may also give other countries time to be better prepared for the coming 6th wave driven by Omicron BA.2.