bluuebunny/crossref_metadata_2025 huggingface dataset:
Natural Language Processing for Sentiment Analysis in Social Media Posts to Identify Suspicious Behaviour
Authors: Gagandeep  , Verma Jyoti
Published: October 2024

This article reports a study on the use of the natural language processing approach in the sentiment analysis of social media posts for detecting suspicious activities involving deep learning methods. The primary objective is to design an automated system capable of identifying unfavourable sentiments and patterns that imply suspicious activity such as cyberbullying, hate speech and disinformation. The methodology involves collecting a diverse data set of 2,000 posts from platforms such as X and Facebook, pre-processed by tokenisation and normalisation. The sentiment analysis model uses a long short-term memory (LSTM) network because it finds that the LSTM network is good for recognising long-term dependencies between texts. Other heuristics are used to give prominence to posts with malicious behavioural profiles to flag them accordingly. The model is designed and tuned to pre-labelled data sets. This work shows considerable improvement over previous techniques at categorising the posts as suspicious by showing higher accuracy, precision, recall and F1 score ratios. In doing so, this research positively impacts the enhancement of paranoid security or the totality of social media safety by offering a strong early detection mechanism for reducing risky behaviours on social networks.
Evaluation and Analysis of Traditional Chinese Medicine Treatment of Bovine Viral Diarrhea/Mucosal Disease Based on Network Pharmacology and In Vitro Studies
Authors: Chen Liang , Lan Shijie , Shen Sisi , Wang Jiahui , Liu Xuesong , Jiang Botao , Zhong Peng , Liu Bochao , Yao Shuang , Qin Pingwei , Feng Wanyu
Published: October 2024

Background

Bovine viral diarrhea/mucosal disease (BVD-MD) is widely distributed worldwide. The disease causes serious economic losses to animal husbandry every year. Finding targeted antiviral drugs proves to be an effective strategy.

Purpose

This study was based on network pharmacology and in vitro studies to analyze the potential of traditional Chinese medicine (TCM) in the treatment of BVD-MD.

Methods

The intersection targets between TCM and the disease were identified. Network topology analysis and protein–protein interaction (PPIs) networks were performed. Intersection targets were analyzed for gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) enrichment. The molecular docking and molecular dynamics simulation methods were used to reveal the degree of binding of core components to key target genes. Characterization of the anti-Bovine viral diarrhea virus (BVDV) effect of TCM by cytotoxicity and in vitro studies.

Results

The results revealed the selection of five key Chinese medicines, along with 206 targets associated with BVD-MD. The toll-like receptor, PI3K-AKT, and tumor necrosis factor (TNF) signaling pathways were closely related to the five TCMs. AKT1, EGFR, HSP90AA1, and MAPK1 had good binding with quercetin, the core component of Chinese medicine. Molecular dynamics analysis showed that quercetin exhibited complex stability with AKT1. In vitro studies have demonstrated that the inhibitory effect of quercetin on BVDV is mainly in the initial phase. Quercetin inhibited the expression of AKT1.

Conclusion

The mechanism of BVDV inhibition by the core Chinese medicines is closely related to MAPK1, AKT1, TNF, and HSP90AA1, with the reduction of AKT1 ultimately affecting viral expression.
Oral Gastrografin: A Safe Alternative in Meconium Obstruction of Prematurity
Authors: Lingesan Kaviarasan , Pendem Venkatasirisha , M. Kulandaivel , Subramanian Mahadevan , Deivasigamani Aniruthan , Segaran Premkumar
Published: October 2024

Meconium obstruction of prematurity is primarily seen among very low birthweight or extremely low birthweight premature babies, causing low intestinal obstruction. It may delay the establishment of early full enteral feeding and compromise nutrition or cause obstruction requiring surgery or intestinal perforation. Currently, the management is mainly based on expert opinion and low-quality evidence. Conventional hyperosmolar contrast enema and gastrografin enema may not reach the site of obstruction because of the proximal nature of the meconium obstruction. Oral gastrografin is an effective and safe alternative for relieving meconium obstruction in a 28-week preterm baby. This avoids the need for surgery. This article highlights the use of oral route of gastrografin as a good nonsurgical alternative in extreme preterm babies in resource-limited circumstances.
Comparison of Problem-based Learning and Didactic Lecture as a Teaching–Learning Method among Undergraduate Medical Students: An Interventional Study
Authors: Anthony Leena , A Radha , T Indushree , Banerjee Swati
Published: October 2024

Background

Didactic Lecture (DL) is a teaching method that has been there for a long time in our educational system, but student involvement is minimal. Problem-based Learning (PBL) differs in that it involves students in the learning process. Various skills are learned, such as self-learning, group discussion, communication skills, teamwork and knowledge retention. Critical thinking, analysis and the ability to solve real problems are some benefits of PBL, which can help medical students understand clinical scenarios and analyse, interpret and come up with possible solutions based on sound knowledge. Thus, there is a need to assess the effectiveness of PBL in recall, interpretation and problem-solving skills as compared to the traditional lecture method, as there are very few Indian studies related to PBL in Indian medical students.

Materials and Methods

A non-randomised interventional study was carried out in the Department of Pharmacology at East Point Medical College, Bengaluru. Groups A and B, each with 60 medical students, participated in PBL and DL for either of the two competencies (myocardial infarction and iron deficiency anaemia). After the completion of the DL and PBL sessions, 20 multiple-choice questions (MCQs) were given to the students. The effectiveness of the teaching method was determined by comparing the mean scores of MCQs of both groups.

Results

The group scores were compared using an independent sample t-test and expressed as mean ± standard deviation. The total mean score of PBL for the topic myocardial infarction (11.00 ± 2.64, p value = .001) was statistically significant compared with the total mean score in the DL group (9.38 ± 2.52), and the total mean score of PBL for the topic iron deficiency anaemia (15.28 ± 3.53, p value = .001) was significant compared to the total mean score in the DL group (12.98 ± 3.61), respectively. The mean score for recall and problem-solving for the topic of myocardial infarction was statistically significant in the PBL group compared to the DL group. The mean score for recall, interpretation and problem-solving for the topic of iron deficiency anaemia was statistically significant in the PBL group compared with the DL group.

Conclusion

PBL showed marked improvement in recall, interpretation and problem-solving abilities compared with DL. So, including PBL as a teaching–learning method can promote active and student-centered learning.
Knocking on Heaven’s Door? Entrepreneurship, Firm Growth, and Health Risks
Authors: Partanen Jukka , Tenhiälä Aino , Kautonen Teemu , Jokela Markus , Lerner Daniel A. , McKelvie Alexander
Published: October 2024

We examine the physical health consequences to entrepreneurs of firm growth and decline. Using register-based panel data (2000–2021), we find that entrepreneurs and hired CEOs are, on average, healthier and live longer than individuals from a socio-economically similar random sample from the general population. However, our findings also reveal that entrepreneurs are more likely to fall ill during their tenure and die younger than hired CEOs. Importantly, our findings demonstrate that both cumulative exposure to growth and episodic, rapid declines in sales and in the number of employees are equally taxing for entrepreneurs and hired CEOs.
Exploring a Language-Based Interest Assessment: Predicting Vocational Interests on Social Media Using Natural Language Processing
Authors: Du Yan Yi Lance , Jain Devansh , Cho Young-Min , Hou Daphne Xin , Guntuku Sharath Chandra , Ungar Lyle , Tay Louis
Published: October 2024

For more than a century, self-report inventories have been the traditional method for assessing vocational interests. Little research has examined the use of machine learning techniques, such as natural language processing (NLP), in interest assessment. This paper explores the extent to which natural language on social media can be used to predict individuals’ self-ratings on eight basic interests representing the SETPOINT model: Agriculture, Engineering, Human Resources, Life Science, Management/Administration, Mechanics/Electronics, Media, and Social Science. Leveraging closed- (Linguistic Inquiry and Word Count; LIWC) and open-vocabulary NLP approaches (Latent Dirichlet allocation (LDA) topic modeling), we analyzed 3.2 million Facebook posts from 2,834 participants who completed a 32-item basic interest measure. We found that the convergent validities of these NLP approaches for predicting vocational interest scores (LIWC: [Formula: see text] = 0.19; LDA topic modeling: [Formula: see text] = 0.24) are comparable to prior research on language-based personality assessments. Our study also revealed largely face-valid language markers that characterize different basic interests. Implications for developing language-based interest assessments for applied settings (e.g., career guidance and employee selection) and future research directions are discussed.
“They Need to Feel Non-Judgmental”: Results of Participatory Photovoice Research to Inform Lung Cancer Screening Imagery
Authors: Hirsch Erin A. , Hoover Kaitlyn , Studts Jamie L.
Published: October 2024

Introduction

Effective communication and messaging strategies are crucial to raise awareness and support participants' efforts to adhere to lung cancer screening (LCS) guidelines. Health messages that incorporate images are processed more efficiently, and given the stigma surrounding lung cancer and cigarette smoking, emphasis must be placed on selecting imagery that is engaging to LCS-eligible individuals. This exploratory study aimed to identify person-centered themes surrounding LCS imagery.

Materials and Methods

This qualitative study leveraged a modified photovoice approach and interviews to define descriptive themes about LCS imagery. Study participants eligible for annual LCS who had a CT scan within 12 months were asked to select three images and participate in a semi-structured interview about photo selection, likes, and dislikes. Participants were also asked their opinions about images from current LCS communications featuring matches, smoke, and cigarettes. Data were analyzed using an inductive thematic approach.

Results

Data saturation was reached after thirteen individuals completed the photovoice activity; each participant selected three pictures resulting in a total of 39 images representing LCS. Over half (54%) of images selected contained lungs and only 4 (10%) contained smoking-related elements. Five main themes emerged: 1) images should focus on good news and early detection; 2) people should be relatable; 3) pictures with lungs can dually support lung health or invoke fear; 4) opportunity for education or awareness; and 5) should not be judgmental and induce stigma.

Conclusions

These findings suggest that LCS imagery should not contain negative or stigmatizing elements but instead be relatable and educational. This information can inform communication and messaging interventions and strategies for future LCS participation, awareness, and educational research.
Adaptive neural network backstepping control for the magnetorheological semi-active air suspension system with uncertain mass and time-varying input delay
Authors: Zhao Rongchen , Huang Wenye , Xie HaiFeng
Published: October 2024

Aiming at rejecting external disturbance induced by the random road profile, this paper proposes an adaptive robust control strategy to address the control problem of semi-active air suspension system installed with magnetorheological dampers (MRD) for enhancing ride comfort and handling performance. To effectively depict the inherent nonlinear dynamics of the adjustable air spring, a radial basis function neural network (RBFNN) model is trained by the experimental data offline, and an adaptive learning algorithm is introduced to maintain the modeling accuracy. Moreover, to handle the prevalent sensitive parameter variation (such as sprung mass), a nonlinear estimator is designed to estimate the uncertain sprung mass. Furthermore, a delay compensator is integrated into the control law to mitigate the impact of the time-varying input delay caused by the actuator of MRD to restrain the chattering phenomena. Additionally, the stability of the closed-loop system is rigorously proven by employing a Lyapunov–Krasovskii functional, guaranteeing the boundedness of both tracking error and estimation error. Simulation results are displayed and analyzed, illustrating the feasibility and efficiency of the proposed control strategy in depressing the sprung mass acceleration and tire deflection, showing its significance in both control performance enhancement and chattering elimination.
“My Cross to Bear”: Mothering in the Context of Intimate Partner Violence Among Pregnant Women in Mexico
Authors: Gilliam Hannah C. , Martinez-Torteya Cecilia , Carney Jessica R. , Miller-Graff Laura E. , Howell Kathryn H.
Published: October 2024

Intimate partner violence (IPV) during pregnancy negatively affects both maternal and infant health, yet gaps remain in understanding factors that maintain violence and/or promote resilience within the context of mothering. Nine focus groups were conducted with pregnant and/or IPV-exposed women ( n  =  17) and service providers ( n  =  26) working with these women in Nuevo León, Mexico. Thematic analysis of the focus group data revealed the detrimental impact of cultural norms that prioritize the relationship with women's partners, marriage, and family above women's dignity. Participants also identified ways that values regarding motherhood function as motivation for women to pursue a life without violence.
Adaptive coping, emotions, and antiretroviral therapy adherence among gay, bisexual, and other men who have sex with men (gbMSM) with HIV
Authors: Foley Jacklyn D , Bernier Lauren , O’Cleirigh Conall , Mayer Kenneth H , Moskowitz Judith T , Batchelder Abigail W
Published: October 2024

This study evaluated the hypothesis that positive emotions attenuate associations between negative emotions with adaptive coping and adherence, as well as explored evidence of the hypothesis of an indirect effect association between adaptive coping and adherence via positive emotions. The sample was 202 gbMSM with HIV who use substances (mean age [standard deviation] = 47.15 [12.26]; 34% Black, 14% Hispanic, and ≥50% with annual income ≤$20,000). Positive emotions were a moderator: negative emotions were not associated with approach coping at low positive emotions but were associated with more adaptive coping at high positive emotions ( b = 0.32, p = 0.01). There was also an indirect effect association between adaptive coping with better adherence via high positive emotions (indirect effect: 0.29, 95% Confidence Interval = 0.004–0.39). Findings support the likely benefit of experiencing positive emotions, and investment in intensive longitudinal studies on how emotions, coping, and health behaviors are related to inform behavioral intervention development.
Seismic analysis and performance of semi-active spring for base-isolated structures
Authors: Jangid R.S.
Published: October 2024

The present study investigates the performance of a semi-active spring (SAS) in the mitigation of the seismic response of base-isolated structures. Initially, under stationary filtered white-noise earthquake excitation, the response of the multi-floor flexible base-isolated structure with SAS is examined to observe the response control effects. The equivalent linearization technique is used to obtain the stochastic response, as the force-deformation behaviour of SAS is non-linear. The performance of SAS in terms of added stiffness, damping, and response mitigation to the isolated structure is also investigated. It is found that the SAS controls the isolator displacement effectively. Furthermore, it was noted that there is an optimum stiffness value for the SAS devices for a particular system and excitation, at which point the RMS top floor acceleration reaches a minimum value. Next, approximate formulas are proposed for the RMS isolator displacement, the top floor absolute acceleration, and the optimum stiffness of the SAS. It is observed that these formulas accurately predict the expected response and can be applied to the initial design of base-isolated structures using SAS. Finally, using the non-linear model of the SAS, the seismic response of flexible base-isolated structures is determined for actual near-fault earthquakes, considering different values of the isolation periods and stiffness of the SAS device. The SAS was effective in controlling the isolator displacement under near-fault motions. The trends of the results of isolated structures with SAS devices under near-fault earthquake motions were also in good agreement with those under stochastic excitation.
Human trafficking in nairaland digital community: A corpus-assisted critical discourse study
Authors: Osisanwo Ayo
Published: October 2024

Human trafficking in Nigeria as a topical issue has enjoyed more sociological interrogation with very scant attention in linguistics and discourse. This paper applies a corpus-assisted critical discourse study to examine representative posts on human trafficking in Nigeria (2019 to 2022) retrieved from the Nairaland digital community. Using the Sketch Engine corpus tool and social actors representation model, this paper investigates how different constructions were deployed by participants to represent human trafficking, human traffickers and traffick victims in Nigeria. Findings suggest four constructions oriented to negativity: prostitution/commodification of sex, abuse of underage for sexual satisfaction, maltreatment of others for huge labour, dismembering of humans for occultism and health-assurance. Participants deployed role allocation, nominalisation, and others to negatively evaluate human traffickers, especially as economic usurpers, exploiters, and fraudsters, while the traffick-victims were represented as naïve, non-violent, armless, defenceless and (in)active recipients of the activities of the human traffickers. The dominant negative constructs manifested implicitly and explicitly through tagging, negative comparison, appeal to sentimentalities, and expression of detest, while the positive constructs of victims manifested through pity and appeal to humanity. Online participants attack the political class, and declare their ideological stances on human traffickers in Nigeria, making efforts to project suppressed stances.
Influence of multiple friction stir welding passes on the microstructure and mechanical properties of AA2024 age-hardened aluminum alloy
Authors: Yadav Sunil Kumar , Yusufzai Mohd Zaheer Khan , Mishra Sanjay , Singh DK
Published: October 2024

Friction stir welding (FSW) is a promising joining process for age-hardened aluminum alloys. However, when the process is used for welding age-hardened aluminum alloys, the hardness and joint efficiency are poor mainly because the strengthening precipitates become incoherent and/or get dissolved during the welding process. In this novel work, efforts have been made to enable the reprecipitation of the strengthening precipitates using multi-pass FSW. After producing FSW welds on AA2024 alloy, the welds have been processed by the same tool and at the same parameters several times to facilitate the reprecipitation of strengthening precipitates. As the precipitation kinetics of age-hardened aluminum alloys are temperature-dependent, a thermal imaging camera was utilized to record the temperature history during welding and subsequent cooling of the welded plates. The metallurgical examination of welded samples was carried out using optical microscopy, Scanning Electron Microscope (SEM), energy dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), and microhardness test. It was observed that grain refinement occurs continuously due to dynamic recrystallization and severe plastic deformation up to the third FSW pass, after which there is no significant change in grain size. Generally, the microhardness value was higher in the stir zone than the heat-affected zone (HAZ), and the hardness in the stir zone increased after 4 passes of FSW. SEM images show clusters of incoherent precipitates, fragmentation, precipitate dispersion, dissolution, and reprecipitation of precipitates during each subsequent pass. The identification of the precipitates was carried out using EDS and XRD analysis.
Evolution of TiAlSi thin film coatings under varying target power in DC magnetron sputtering
Authors: Wambua Job , Mwema Fredrick , Zoppi Guillaume , Woo Wai-Lok , Akinlabi Esther
Published: October 2024

This study, for the first time, presents the growth, nucleation, and characteristics of TiAlSi thin films sputtered from a partially sintered Ti30Al16Si10 (at. %) composite target under controlled conditions of target power. The TiAlSi thin films were grown on soda-lime glass substrates through Direct Current (DC) sputtering at varying levels of the target power: 73.2 W, 151.2 W, and 269.5 W. The other deposition parameters: the deposition temperature, time, argon mass flow rate, substrate rotation, and deposition pressure, were kept constant at 23 °C, 150 min, 25 sccm, 5 rpm, and 10−3 mbar, respectively. The pre-sputter power, argon flow rate, and time were also kept constant at 73.2 W, 20 sccm, and 5 min, respectively. The physical properties, microstructure, crystal structure, topography, and mechanical properties of the thin film coatings were analysed. The thickness and rate of deposition of the TiAlSi thin films increased with an increase in the target power (73.2 W – 269.5 W) from 414.6 nm and 0.046 nm/s to 1358.8 nm and 0.151 nm/s, respectively. The chemical composition of all the thin films remained constant, with the formation of a uniform TiAlSi alloy with no segregation of elements. However, a thin (wetting) interlayer consisting of Si and O elements was observed between the TiAlSi layer and the glass substrate. Further, the structure sizes and roughness values of the TiAlSi thin films increased with an increase in the target power, with a maximum of 75.4 nm for the size and 4.78 nm for the RMS roughness of thin films deposited at the maximum target power (269.5 W). Lastly, mechanical analysis of the TiAlSi thin films depicted an increase in the hardness as the target power increased, with the highest hardness at maximum power (269.5 W) obtained as 4.76 GPa. Despite having the lowest elastic modulus (50.5 GPa), the coating deposited at the highest power exhibited the highest plasticity index (H/E) and plastic deformation factor (H3/E2) of 0.094 and 0.042 GPa, respectively, which indicated the high resistance to abrasive wear, cracking, and deformation, compared to thin films deposited at the lowest target power (H/E = 0.066 and H3/E2 = 0.015 GPa). This study demonstrates that target power is a significant factor in determining the growth of TiAlSi thin films during the sputtering process and can be used for better control of their physical, structural, and mechanical properties.
Entrepreneurs’ decision-making in sustainable open innovation practices
Authors: Almeida Fernando
Published: October 2024

Entrepreneurs’ decision-making in sustainable open innovation practices holds significant relevance in fostering environmentally conscious and socially responsible business strategies. Sustainable decision-making not only aligns with ethical principles but also addresses pressing global challenges such as climate change and resource depletion. This study aims to characterize the decision-making role played by entrepreneurs in the context of the open innovation paradigm and to understand the factors that influence entrepreneurial performance. A quantitative methodology supported by Partial Least Squares Structural Equation Modeling was adopted, considering a sample of 407 startups incubated in science and technology parks. After that, a mixed-methods approach was employed to explore the differences between sectors of activity, in which 4 ventures were involved. The results confirm that of the 9 hypotheses formulated in the relationship between the constructs, only innovation novelty is not significant for sustainable open innovation management processes, unlike innovation openness. This study offers theoretical and practical implications for startups that intend to use open innovation networks to integrate environmental and social considerations into the core of business strategies.
‘Am I resistant to a military wife identity? Maybe not entirely’: Animating life history interviews as fictive diaries
Authors: Huddlestone Emma
Published: October 2024

In recent years academics have questioned how findings may be presented in ways that centre the complex, rich and nuanced reflections heard and felt in qualitative research – and if this is even possible. We are witnessing a creative turn as ‘data’ is being translated into art-forms to reach wider audiences in sensory formats. Such endeavours open opportunities to move beyond the confines of conventional practices of academic writing, creating space for rethinking how we might attempt to show the textured and felt stories shared by participants. In the spirit of these endeavours, this article explores the opportunities afforded by authoring life history interviews into fictive diaries. Through doing so, this article argues that research could be animated in this way to show the complex emotionality and temporality that underpins participant narratives, perhaps even evoking an emotional, empathetic, response in the reader as they are drawn into participants’ stories.
Swirling Flow Quantification in Helical Stents Using Ultrasound Velocimetry
Authors: Ghanbarzadeh-Dagheyan Ashkan , van Helvert Majorie , van de Velde Lennart , Reijnen Michel M.P.J. , Versluis Michel , Groot Jebbink Erik
Published: October 2024

Objective:

Helical stents have been developed to treat peripheral arterial disease (PAD) in the superficial femoral artery (SFA), with the premise that their particular geometry could promote swirling flow in the blood. The aim of this work is to provide evidence on the existence of this swirling flow by quantifying its signatures.

Materials and Methods:

This study consists of in vitro and in vivo parts. For the in vitro part, 3 helical stent models of different helicity degrees and 1 straight model were fabricated, and the flow was assessed at the inlet and outlet of each model. For the in vivo part, only 1 patient, treated with the helical stent, was eligible to participate in the study. The stent implanted in the SFA of the patient was evaluated in 2 leg postures (straight and flexed), and flow was assessed in 12 locations along the SFA. The in vivo study was approved by an ethical board (NL80130.091.21) in the Netherlands. High-frame-rate ultrasound was used to acquire data from the regions of interest (ROIs), using microbubbles as contrast agents. After processing the data via a correlation-based algorithm (echo particle image velocimetry or echoPIV), the velocity vector field within each ROI was extracted and analyzed for parameters such as vector complexity and velocity profile skewedness.

Results:

The results show that in the outlet of the helical stents, when compared with the inlet, the flow vector field is more complex and the velocity profile is more skewed. For the in vivo case, the outcomes demonstrate more complexity and higher variability in the sign of skewedness inside the stent when compared with the flow in the proximal to the stent.

Conclusions:

Helical stents make the vector field of the flow more complex and the velocity profile more skewed, both of which are signatures of swirling flow. Further studies are needed to evaluate whether these features can benefit patients in terms of patency rates.

Clinical Impact

This study demonstrates that helical stent models alter the blood flow when compared with straight stent models. Particularly, the flow grows more complex and its velocity profile becomes more skewed, both of which hint at the existence of swirling flow inside the helical stent. These observations, alongside with population-based studies that are currently being carried out, may provide the evidence that helical stents have some advantages over straight stents for the patients.
Successful Pedal Bypass in a Patient With Pseudoxanthoma Elasticum
Authors: Väärämäki Suvi , Hautero Olli , Rajala Vesa , Nevalainen Pasi
Published: October 2024

Objectives

Pseudoxanthoma elasticum (PXE) is a rare metabolic disease, causing calcification in the arterial media layer and further peripheral artery disease (PAD). A high rate of failure has been reported after endovascular and open surgical management of PAD among patients with PXE. Critical limb ischemia (CLI) rarely develops in PXE, and there are only few reports of its treatment.

Methods

We present a case report of a 57 year-old female diagnosed with pseudoxanthoma elasticum (PXE). She presented with critical limb ischemia (CLI) and was successfully treated with pedal bypass using the great saphenous vein.

Results

Despite obtaining suboptimal outcomes through the initial approach of percutaneous transluminal angioplasty to treat critical limb ischemia, the subsequent bypass operation proved to be a success. At the first follow-up appointment at 1 month, the patient was asymptomatic and the ulceration had almost healed. The patient underwent an ultrasound examination at 3, 6, 12, and 24 months after discharge, and the surveillance was uncomplicated.

Conclusions

With a clear indication for surgery, limb-threatening ischemia can be successfully treated with distal bypass, if necessary, in patients with PXE similarly to atherosclerotic PADs. Appropriate diagnostic and surveillance imaging and the utilization of a multidisciplinary team are key components for effective management of PAD in patients with PXE.
From Humble Leadership to Follower Performance: A Meta-analysis of Relational and Cognitive Mechanisms
Authors: Wu Zhihao , Chen Limei , Zhang Kai
Published: October 2024

Unclarity remains in current literature pertaining to the effects and specific processes of humble leadership, calling for more in-depth reviews for boosting the understanding. Our research focuses on follower performance as an important outcome of humble leadership and aims to conduct a meta-analysis to uncover the mechanisms beneath the effecting process. Integrating social exchange theory and social cognitive theory, we proposed that follower's relationship with the leader and their belief in themselves, respectively acting as relational and cognitive mechanisms, would sequentially mediate the relationship between humble leadership and follower performance, including task performance and organizational citizenship behavior. We adopted meta-analytic structural equation modeling (MASEM) to examine our hypotheses and gained empirical support from the results. With the synthesis of literature, this article exerts to unfold the effecting process and potential mechanisms of humble leadership on follower performance, anticipating to make several theoretical contributions and practical implications as well as providing insights for future research.
From Lawn to Health: Understanding the Prostate Cancer Risk in Light DIY Activities
Authors: Yang Rui , Zhang Xiguang , Chen Chen , Li Ya , Yin Jun
Published: October 2024

This study employs two-sample Mendelian Randomization (MR) analysis to investigate the causal relationship between light DIY activities and prostate cancer. We used single nucleotide polymorphisms (SNPs) associated with light DIY activities obtained from published genome-wide association studies (GWASs) and summary-level genetic data related to prostate cancer from published GWAS. The primary analysis was conducted using the inverse-variance weighted (IVW) method for two-sample MR analysis. Cochran’s Q statistic was used to assess heterogeneity, MR-Egger was employed to detect horizontal pleiotropy, and “leave-one-out” analysis was performed for sensitivity analysis. Given the presence of heterogeneity, the random-effects IVW method was used for the primary analysis. The random-effects IVW results indicated a positive causal relationship between participation in light DIY activities and the risk of prostate cancer (odds ratio [OR] = 1.024, 95% confidence interval [CI]: 1.001–1.048; p = .039). The weighted median (WM) method results supported this finding (OR = 1.025, 95% CI: 1.003–1.048; p = .024). Participation in light DIY activities may slightly increase the risk of prostate cancer. This finding emphasizes the need to carefully consider the types and intensities of physical activities when making public health recommendations and personal lifestyle choices.
Treating Prediabetes With Medications … or Not
Authors: Srivastava Sneha Baxi
Published: October 2024

There is abundant evidence about the impact of physical activity on health. Many of the clinical guidelines include physical activity as a strong recommendation in treatment plans to optimize health outcomes; however it is necessary to consider the interaction between medications and physical activity. There are certain medical conditions, including cardiovascular disease, diabetes, pain and urinary incontinence that may directly impact physical activity as well as medications for those conditions can affect how a person can be physically active. Having individualized conversations with patients to determine ways to incorporate physical activity into their lives may lead to healthier outcomes.
The Vecta 46 intermediate catheter for mechanical thrombectomy of distal medium vessel occlusions: A single-center experience
Authors: Choi Joo Won , Qiao Yang , Mehta Tej I. , Clausen Thomas M. , Zhang Y. Jonathan , Tsappidi Samuel , Hui Ferdinand K.
Published: October 2024

Introduction

With emerging evidence supporting the clinical efficacy and safety of mechanical thrombectomy (MT) for distal medium vessel occlusions (DMVOs), MT devices specifically designed to navigate through smaller caliber and more delicate tortuous distal cerebrovasculature are required. This study describes our single-center experience using the AXS Vecta 46 intermediate catheter for first-line thromboaspiration of DMVOs.

Methods

We identified all patients who underwent MT using the Vecta 46 for first-line thromboaspiration for primary or secondary DMVOs. We collected baseline clinical data, angiographic and clinical outcomes, as well as procedural complications. The primary outcome in question was the rate of successful recanalization, which was defined as a modified Thrombolysis in Cerebral Infarction score of ≥2b.

Results

We identified 43 patients who underwent MT using the Vecta 46 catheter for thromboaspiration of 54 DMVOs. Intervened vessels included the M2 (23/54), M3 (19/54), and M4 (6/54) branches of the middle cerebral artery, A2 (1/54), A3 (1/54), and A4 (1/54) branches of the anterior cerebral artery, and P1 (1/54), P2 (1/54), and P4 (1/54) branches of the posterior cerebral artery. The median number of passes for primary DMVOs was 2 (IQR: 1–3) and 1 (IQR: 1–1.25) for secondary DMVOs. The rate of successful recanalization was 100% (18/18) for primary DMVOs and 80.6% (29/36) for secondary DMVOs. First-pass effect (FPE) was noted in 55.6% (30/54) of all primary and secondary DMVO cases. Improved short-term clinical outcomes were observed in both the primary (National Institute of Health Stroke Scale [NIHSS] shift: −5 [IQR: −14.25 to −0.25]) and secondary (NIHSS shift: −5 [IQR: −10 to −2]) DMVO groups. A total of six patients died during their hospitalization, though none were deemed procedural-related.

Conclusions

Our study demonstrates the safety and efficacy of the Vecta 46 intermediate catheter for thromboaspiration of both primary and secondary DMVOs, achieving high rates of successful recanalization and FPE.
Black Researchers Studying Racial Battle Fatigue Among Black Students
Authors: Quaye Stephen John , Mills Kristen J. , Jones Hunter V. J. , Allen-Stills Na’eem , McKinney Neal J.
Published: October 2024

In this paper, we explore what it means to be Black researchers exploring racial battle fatigue while simultaneously navigating our own racial battle fatigue. We undertook a photo-elicitation project to investigate racial battle fatigue among Black undergraduate and graduate students. Amid doing this work, we wrestled with how to responsibly complete this research while treating participants with care who had full lives, histories, and stories. Using scholarly personal narrative methodology, we make sense of our research process as a research team of five Black people (two faculty members and three graduate students). We share journal entries to underscore the questions with which we were grappling in the research process, ultimately, to help readers understand our answer to the question: What does it mean to center racial battle fatigue in educational research when Black researchers are navigating their own racial battle fatigue? We close the article with lessons learned from our process to leave readers with ideas to consider as they embark on their own journeys of researching a topic with which they are also experiencing.
Long-term subjective and objective outcomes after digital nerve repair: a cohort study
Authors: Evertsson Linda , Björkman Anders , Turesson Christina , Arner Marianne , Mellstrand Navarro Cecilia
Published: October 2024

Digital nerve injuries are common, but few studies report long-term effects for the individual. The primary aim of this matched-pairs study comparing digital nerve injuries in border digits or central fingers was to investigate hand function 3–10 years after digital nerve repair, assessed using the Mini Sollerman test in 86 patients. Secondary outcomes were sensory function, range of motion, grip strength and patient-reported measures. No significant difference was seen in hand function between the groups, except for lower grip strength in patients with central finger injury. Tactile discrimination was achieved in 87%, with best results among participants aged less than 44 years. Touch perception was measurable in 99%. No statistically significant differences in sensory function were found between the groups. Patient-reported disability was low, with median Quick Disabilities of the Arm, Shoulder and Hand score of 5, but half of the patients reported neuropathic pain. Numbness and cold sensitivity were the symptoms graded worst after digital nerve injury.

Level of evidence: III
Primary Stapedectomy: A Retrospective Review of Surgical Results Using a Cold Steel Technique and Pre-Operative CT Correlates
Authors: Hudson Thomas J. , Mijovic Tamara , Rappaport Jamie M.
Published: October 2024

Importance

Stapedectomy is an effective treatment option for patients with symptomatic otosclerosis. A common surgical technique today is laser stapedotomy, although the equipment required adds a significant cost to the procedure and may not be available in certain, particularly remote, centers. This study aimed to evaluate cold steel stapedectomy in a modern otology practice as a cost-effective and versatile alternative.

Objective

The primary objective was to evaluate the efficacy and safety of cold steel stapedectomy. The secondary objectives included characterizing the prevalence of relevant computed tomography (CT) findings and evaluating other factors such as piston size.

Design

A retrospective case series from April 2006 to November 2021.

Setting

A single tertiary care hospital in Montreal, QC, Canada.

Participants

Patients with suspected otosclerosis and no prior stapes surgery.

Intervention

Cold steel primary stapedectomy.

Main Outcome Measures

In primary analysis, change in pure tone thresholds, pure tone average (PTA), and complication rates were obtained. Secondary analysis measures included rates of relevant CT findings and change in PTA with piston size.

Results

A total of 302 cases were included in the analysis. The average change in air conduction PTA was a decrease of 27 dB, with 91% (276/302) having over 10 dB of improvement. The air-bone gap was closed to within 10 dB in 82% (248/302) of cases and within 20 dB in 96% (290/302) of cases. Overclosure occurred in 19% of cases, while only 4% resulted in worsened PTA bone conduction thresholds. In secondary analysis, 74% of CT scans demonstrated radiologic otosclerosis. Other findings included suspected superior semicircular canal dehiscence in 1.8%.

Conclusion

Cold steel stapedectomy was demonstrated to be a safe and effective technique, with audiometric results comparable to laser and drill studies in recent literature. It should be considered as a cost-effective and global health accessible alternative. Additionally, CT scans can provide valuable information in the pre-operative workup.
Closed-Loop Therapy and Sleep in Young People Newly Diagnosed With T1D and Their Parents
Authors: Madrid-Valero Juan J. , Scott Eleanor M. , Boughton Charlotte K. , Allen Janet M. , Ware Julia , Wilinska Malgorzata E. , Hartnell Sara , Thankamony Ajay , Randell Tabitha , Ghatak Atrayee , Besser Rachel E.J. , Elleri Daniela , Trevelyan Nicola , Campbell Fiona M. , Hovorka Roman , Gregory Alice M.
Published: October 2024

Background:

A diagnosis of type 1 diabetes in a young person can create vulnerability for sleep. Historically it has been rare for young people to be offered a closed-loop system soon after diagnosis meaning that studies examining sleep under these circumstances in comparison with standard treatment have not been possible. In this study, we examine sleep in young people (and their parents) who were provided with hybrid closed-loop therapy at diagnosis of type 1 diabetes versus those who receive standard treatment over a 2-year period.

Methods:

The sample comprised 97 participants (mean age = 12.0 years; SD = 1.7) from a multicenter, open-label, randomized, parallel trial, where young people were randomized to either hybrid closed-loop insulin delivery or standard care at diagnosis. Sleep was measured using actigraphy and the Pittsburgh Sleep Quality Index (PSQI) in the young people, and using the PSQI in parents.

Results:

Sleep in young people using hybrid closed-loop insulin delivery did not differ significantly compared with those receiving standard care (although there were nonsignificant trends for better sleep in the closed-loop group for 4 of the 5 sleep actigraphy measures and PSQI). Similarly, there were nonsignificant differences for sleep between the groups at 24 months (with mixed direction of effects).

Conclusions:

This study assessed for the first time sleep in young people using a closed-loop system soon after diagnosis. Although sleep was not significantly different for young people using closed-loop insulin delivery as compared with those receiving standard care, the direction of effects of the nonsignificant results indicates a possible tendency for better sleep quality in the hybrid closed-loop insulin delivery group at the beginning of the treatment.
Association of Continuous Glucose Monitoring–Derived Glycemia Risk Index With Cardiovascular Autonomic Neuropathy in Patients With Type 1 Diabetes Mellitus: A Cross-sectional Study
Authors: Jun Ji Eun , Lee You-Bin , Kim Jae Hyeon
Published: October 2024

Background:

The glycemia risk index (GRI) is a new composite continuous glucose monitoring (CGM) metric for weighted hypoglycemia and hyperglycemia. We evaluated the association between the GRI and cardiovascular autonomic neuropathy (CAN) and compared the effects of the GRI and conventional CGM metrics on CAN.

Methods:

For this cross-sectional study, three-month CGM data were retrospectively analyzed before autonomic function tests were performed in 165 patients with type 1 diabetes. CAN was defined as at least two abnormal results of parasympathetic tests according to an age-specific reference.

Results:

The overall prevalence of CAN was 17.1%. Patients with CAN had significantly higher GRI scores, target above range (TAR), coefficient of variation (CV), and standard deviation (SD) but significantly lower time in range (TIR) than those without CAN. The prevalence of CAN increased across higher GRI zones ( P for trend <.001). A multivariate logistic regression analysis, adjusted for covariates such as HbA1c, demonstrated that the odds ratio (OR) of CAN was 9.05 (95% confidence interval [CI]: 2.21-36.96, P = .002) per 1-SD increase in the GRI. TIR and CV were also significantly associated with CAN in the multivariate model. The area under the curve of GRI for the prediction of CAN (0.85, 95% CI: 0.76-0.94) was superior to that of TIR (0.80, 95% CI: 0.71-0.89, P for comparison = .046) or CV (0.71, 95% CI: 0.57-0.84, P for comparison = .049).

Conclusions:

The GRI is significantly associated with CAN in patients with type 1 diabetes and may be a better CGM metric than TIR for predicting CAN.
The anti-inflammatory effect of the extract and aristolactam BII isolated from aerial parts of Houttuynia cordata Thunb
Authors: Pham Ty Viet , Ho Duc Viet , Nguyen Nguyen Hoai , Tran Gia-Buu , Thao Tran Thi Xuan , Dat Nguyen Minh Thanh , Vo Nguyen Huy Hoang , Tran Kieu Anh , Do Bich Hang
Published: October 2024

Objectives

Houttuynia cordata Thunb., a member of the Saururaceae family, has been demonstrated to have potential in the treatment of different diseases. For the first time, aristolactam BII was isolated from the aerial part of Houttuynia cordata Thunb. and the anti-inflammatory effect of the extract and aristolactam BII was evaluated.

Methods

After using chromatography to separate and obtain the compound, Nuclear Magnetic Resonance was used to identify the compound. An in vivo model of carrageenan-induced paw edema on mice was performed to test the anti-inflammation of the extract and compound. Furthermore, a ligand docking experiment was performed to determine the binding free energy of aristolactam to inflammatory proteins including COX-1, COX-2.

Results

The findings showed that aristolactam BII effectively reduced the severity of the edema, similar to diclofenac, whereas the methanol extract showed low effectiveness. Particularly, the swelling rate of 50 mg/kg aristolactam BII treated mice was only 26.2 ± 7.1% (p < 0.01) after 5 h treatment. The in silico results described that aristolactam BII might inhibit COX-1 and COX-2 via creating h-bonds at the sites of Ser 530 residues.

Conclusion

Our results demonstrate the potential anti-inflammatory activity of aristolactam BII. This study would provide more fundamental knowledge about the bioactivities of aristolactam BII isolated from Houttuynia cordata.