bluuebunny/crossref_metadata_2025 huggingface dataset:
Influential factors contributing to the understanding of international students’ choice of Malaysian higher education institutions: Qualitative study with a focus on expected benefits
Authors: Haniya Osama K. , Said Hamdan
Published: May 2022

This research aimed to identify the influential factors contributing to the international students’ choice of Malaysian Higher Education Institutions (HEIs), focusing on the expected benefits. Additionally, the study contributes to the development of the higher education sector in Malaysia by providing recommendations to the HEIs based on the students’ perceptions. To achieve this purpose, the researchers utilized a qualitative approach through interviews where the study targeted the international students in Malaysia; 18 students were interviewed until saturation was reached. The thematic analysis was utilized to analyze the interviews where five major influential factors were highlighted and investigated: reliability, assurance, tangibility, empathy, and responsiveness. The results showed that the Malaysian universities provide higher than average services to international students, which met most of their expectations; this is clear through the international students’ answers to questions under different constructs such as reliability, assurance, tangibles, empathy, and responsibility. The international students believe that the brand image and reputation of HEIs have a positive impact on their choice and expectations, and they believe that Malaysian HEIs are among the world’s top universities. The study contributes to Malaysian HEIs in terms of the students’ feedback that could be an advantage for existing efforts to develop the academic services of the country.

Received: 17 January 2021Accepted: 18 February 2022
COVID-19 Special Section: Introduction. Emerging from the pandemic: Can the future be resilient, proactive, and sustainable?
Authors: Greere Anca
Published: May 2022

This introduction to the Special Section on COVID-19 experiences, impact, and implications for higher education emphasises the importance of recognising the opportunities and challenges posed by the pandemic experience, especially through emergency remote teaching and learning arrangements, and outlines various studies conducted to pinpoint recommendations for future action within higher education. The conclusions reached reinforce the notion that solutions are context-dependant and culture-specific; still, a high degree of transferability is exhibited across the four continents represented in the Special Section.
Süt Sağma Makinesinde Asenkron Motorun Performansının Deneysel Olarak Değerlendirilmesi
Authors: GÜNGÖR ÇELİK Ayşegül
Published: May 2022

Ülkemizde ve dünyada yaygın olarak kullanılan, endüstriyel alandan evimize kadar birçok makinelerde yer alan, bakım maliyetinin az olmasıyla birlikte az arıza çıkaran asenkron motorlar süt sağma makinelerinde de kullanılmaktadır. Bu çalışmada, asenkron motorlarının dinamofren test cihazında, motor soğuk iken direnci, nominal yük altında verimliliği, motor boşta çalışırken güç ve akım değerleri, kilitli rotor testi ile motor momenti, akımı ve giriş gücü değerleri ile devrilme momenti sonuçları, aynı zamanda motor tam yük altında ve değişik gerilimlerde, sabit gerilimde değişik yüklerde akım, güç, moment ve verimlilik sonuçları incelenmiştir. Sonrasında süt sağma makinesine takılan asenkron motorun, gerilim sabit tutularak değişik vakum değerlerinde akım, güç ve devir sayılarını, vakum sabit tutularak değişik gerilim değerlerinde akım, güç ve devir sayılarının değişimleri araştırılmıştır. Bu deneysel çalışmada, Volt marka asenkron motorlardan 90-4 tipteki 0,55 kw asenkron motor, Sezer marka vakum pompası takılı olan Enka tarım süt sağma makinesinden yararlanılmıştır. Deney sonuçlarına göre asenkron motor tam yükte ve farklı gerilimler altında iken verim değeri %50,4- %68,4 arasında değişmektedir. Bu çalışmayla değişik bölgelerde kullanılan süt sağma makinelerinde bulunan asenkron motorlarının, farklı gerilim, sıcaklık şartlarında ve tam yükte çalışma durumunda, enerji tüketimi ve performansı incelenmiştir.
Effect of Varying Temperature by Covered Plastic Film on Growth and Development of Chickpea
Authors: Satpathi Anurag , Nain A.S. , Setiya Parul
Published: May 2022

Background: Climate change has become a major challenge in cultivation of chickpea and productivity. Negative impacts of climate change are likely to result from the effects of high temperature, low temperature, drought and excessive moisture and these factors affect crop yield ultimately. Methods: Keeping in view for quantifying the effects an experiment was laid out in split plot design. The experiment with three dates of sowing i.e. 12th December 2018 (D1), 22nd December 2019 (D2) and 2nd January 2019 (D3) as main plot treatments and the four microclimatic regimes viz. open field (T1), Open roof (T2), perforated roof (T3) and closed or packed (T4) by 100 GSM plastic film as sub plot treatments was laid to analyse the impact of temperature variation. Result: The major finding of the study is that the chickpea crop sown on 12th Dec. (D1) found highest grain yield (1200 kg ha-1) as compared to 22nd Dec. (845 kg ha-1) and 2nd Jan. (638 kg ha-1). This may be mainly attributed to congenial weather during the entire growing period. By studying the role of weather variables on chickpea in terms of seed yield, it is noticed that best performance of Packed subset (T4) i.e. 1044 kg ha-1 was observed in all dates of sowing followed by Perforated (T3) i.e. 955 kg ha-1, Open roof (T2) i.e. 813 kg ha-1 and Open field (T1) i.e. 765 kg ha-1.
Current Status and Way Forward for Scaling up Productivity of Pigeonpea in Madhya Pradesh: A Review
Authors: Ghritlahre S.K. , Singh Archana , Singh I.P. , Singh Farindra , Katiyar P.K. , Singh N.P.
Published: May 2022

Madhya Pradesh ranks first both in terms of area (25%) and production (32%) of pulses in India. However, it ranks sixth after Uttar Pradesh, Bihar, Haryana, West Bengal and Gujarat in terms of productivity. To realize better yield; recommended production and protection technologies have to be followed. Most of the pigeonpea varieties have been developed by traditional breeding either by pedigree method or selection from landraces or by bi-parental mating. After getting stable male sterile and restorer lines, development of hybrid pigeonpea have been major breeding objectives. Availably of genomic tools by decoding the genome sequence, pigeonpea have been equipped with modern genetic and genomic tools for use in the research programmes. Different approached like mining superior alleles by re-sequencing of wild species, fine mapping for drought tolerance, fertility restoration and developing superior lines by genomic selection, identification of candidate genes which are associated with hybrid vigour by using epi-genomics and mitochondrial genome sequencing and identification of candidate genes and functional markers for water-logging tolerance are already in progress. Transgenic approach has also been initiated to develop resistance against pod borer. Collaborative efforts among ICRISAT, IARI and IIPR-Kanpur are on the way for use of different transgenes and promoter options for developing transgenic plants and their evaluations for effectiveness and bio-safety concerns.
​Brown Manuring-An Eco-friendly Approach towards Sustainability in Agriculture: A Review
Authors: Biswas Saikat , Das Rupa
Published: May 2022

Agriculture sustainability depends on production of crops without hampering natural systems and thus, suggests for eco-friendly approaches to achieve this. Weed, being a major problem in agriculture causes reduction in crop yield and depletes soil nutrients. Although application of inorganic fertilizers or herbicides improves crop yield to an extent, it hampers soil health and environment through toxic substances. In this context, brown manuring, an organic/eco-friendly approach holds good prospect, specially in direct seeded rice. Reviewed research reports clearly explained the benefits of brown manuring in suppression of weeds, sequestration of carbon, biological nitrogen fixation, addition of macro and micro nutrients to soil, saving soil moisture, improving physical, chemical and biological properties of soil etc. As a consequence, various research works reported improvement in crop growth, yield and economic return of rice, maize, sugarcane etc. However, research gap is still present in this regard and therefore, multi-locational, multi-season, multi-crop trials using different brown manure plants at different rates and time of co-culture are needed at this hour to confirm the efficacy of brown manuring for future recommendation. Besides, strong extension service is needed further to transfuse this eco-friendly approach to grass-root level of farming community.
Evaluation of Urea Treated Acacia nilotica Pods as a Feed for Grower Lambs
Authors: Chellapandian M. , Arulnathan N. , Thirumeignanam D.
Published: May 2022

Background: Acacia pods are non-conventional protein rich feed resources that could be harnessed as a feed ingredient in sheep production. Though many workers have observed the utility of raw Acacia nilotica pods as a noteworthy feed for small ruminants, the information on nutritive value of urea treated pods is lacking. Hence the present study was undertaken to evaluate the nutritional potential of urea treated Acacia nilotica pods at different dietary levels for supporting growth and nutrient utilisation in lambs. Methods: Acacia nilotica pods were collected, sun dried and ground in a hammer mill. The ground pods and seeds were treated in bulk with urea. Then the urea treated pods (UTP) was incorporated in three experimental concentrate mixtures @ 0, 15 or 30 per cent (R1, R2, R3) replacing deoiled rice bran. The concentrate mixtures were made isoproteinic and isocaloric. Napier Bajra hybrid grass (CNCO4) was provided as the basal roughage component in the rations. The ingredient and proximate composition of concentrate mixtures. Fifteen ram lambs of native Kilakarsal breed of about six months of age and with an average initial body weight of 9.39 kg were divided on the basis of body weight into three groups with five lambs per dietary group in a completely randomized design. Daily record of feed consumption was maintained. The lambs were weighed at fortnightly intervals. At the end of the feeding experiment, digestion trial was conducted using the same ram lambs. The samples were analysed for proximate composition and the digestibility of nutrients in the three experimental rations were determined. Result: Based on the data analyzed the DMI worked out to be 64.90, 65.84 and 65.43 g/kg W0.75 in lambs fed with rations containing 0, 15 and 30% UTP in the concentrate mixture respectively. The corresponding values for ADG in the present study were 48.14, 47.43 and 48.57 g. The feed efficiency in terms of DMI required to gain one kg body weight were 8.28, 8.58 and 8.35 kg which did not vary between the treatment groups. DCP of experimental rations increased significantly (P≤0.05) as the level of UTP in the concentrate mixture increased which could be attributed to the increased crude protein digestibility. The TDN decreased significantly (P≤0.05) at 15% and level and was unaffected thereafter. Hence, it was concluded that Acacia nilotica pods treated with 5% urea at 40% moisture and stored for 14 days could safely be included up to 30 per cent level in the concentrate mixture of growing lamb ration.
Arsenic Contamination and Their Effects on Leguminous Crops and Consumers: A Review
Authors: Ghritlahre S.K. , Singh Archana
Published: May 2022

Arsenic is harmful to most plants in high concentration as it interferes in metabolic activities and inhibits plant growth and reproduction process by arsenic induced phytotoxocity. It is a cancer inducing metalloid released into environment by both natural as well as anthropogenic activities. It also affects the leguminous crops like lentil and chickpea which is widely grown in these arsenic affected regions of West Bengal in India and in Bangladesh. However, a little is known about the arsenic accumulation on these crops when these crops are grown in the arsenic contaminated soils. Indo-Gangetic and Bramhaputra regions is one of the most arsenic contaminated points in the world and needs sustainable approach to control and avert their harmful effects on the crop plants, animals and human beings.
Effect of Lactation Stages on Biochemical Entities of Indigenous Badri Cattle of Uttarakhand
Authors: Thakur Swati , Maiti A. , Verma M. , Huozha R. , Rastogi S.K. , Dhara S.
Published: May 2022

Background: The indigenous cattle of Uttarakhand, Badri is the first registered cattle breed of the state, mainly reared in Kumaon and Garhwal regions. The present study was carried out in forty healthy cows to evaluate the effect of lactation stages on biochemical entities. Methods: Forty healthy animals were selected and divided into five groups with eight animals in each group during different stages of lactation viz. 0 to 60 days, 61 to 120 days, 121 to 180 days, 181 to 240 days and non-lactating animals. Blood samples were collected during different lactation stages and non-lactation period and serum was harvested. On each serum sample total protein, albumin, globulin, A:G ratio, urea, creatinine, glucose, cholesterol, triglycerides, HDL, LDL, calcium, phosphorus, Ca:P, total bilirubin, ALT, AST, ALP, GGT and CK were determined spectrophotometrically. Result: A significant effect of stages of lactation on serum total protein, albumin, glucose, cholesterol, triglycerides, phosphorus, Ca: P, ALT, ALP and CK was observed (p less than 0.05).
Increased blood-brain barrier permeability correlate with microglial activation at hippocampal CA1 region in acute and chronic bilateral common carotid artery ligation in rats
Authors: Wibisono Dian Prasetyo , Arfian Nur , Pramusinto Handoyo , Munawaroh Fauziyatul , Krisnugraha Yeshua Putra , Tamba Daniel Agriva , Sari Dwi Cahyani Ratna
Published: May 2022

Inflammatory processes might play a key role in the pathogenesis of post-stroke epilepsy. The activation of microglia and release of vascular cell adhesion molecule-1 (VCAM1) might induce blood-brain barrier (BBB) disintegration. However, the influence of such pathomechanisms in the generation of post-stroke epilepsy is still not clear. We investigated whether cerebral ischemia exerts effects on inflammation in the hippocampus by measuring the hippocampal injury score, expression of a microglial marker, and expression of VCAM1 in rats. A total of 24 Sprague Dawley rats were randomized into four groups with 6 rats in eachgroup i.e. sham operation (SO) as control, carotid ligation 1 (GCL1) as an acute model, carotid ligation 3 (GCL3) as a subacute model, and carotid ligation 7 (GCL7) as a chronic model. Immunostaining for microglia marker (CD68) was measured in rat brain tissue sections. The VCAM1 expression was evaluated by reverse transcription-polymerase chain reaction (RT-PCR). Cerebral ischemia increased the amount of microglial immunostaining and expression of VCAM1. The hippocampal injury score and microglial immunopositivity were significantly correlated with the duration of brain ischemia. We conclude that cerebral ischemia is correlated with neuroinflammatory reaction and disturbance of BBB permeability, and the correlation of those molecular impairments with the generation of post-stroke epilepsy remains to be elucidated.
The role of clinical reminder system to drug prescribing on patients of the National Health Insurance with ischemic stroke
Authors: Hiola Faramita , Dwiprahasto Iwan , Pinzon Rizaldy
Published: May 2022

Since 2014 Indonesia has entered the era of universal health coverage (UHC) and public health financing system managed by the Social Security Organizing Agency Law/SSOAL (Badan Penyelenggara Jaminan Sosial/BPJS) . In this system, a national formulary was used as the basis for prescribing drugs by clinicians. One effort for quality and cost control in UHC was to develop a clinical reminder system (CRS) to help prescriber set treatment options in accordance with the national formulary.  The aim of this study was to measure the role of CRS to the compatibility of drug prescribing in patients with ischemic stroke in Bethesda Hospital Yogyakarta, Indonesia. This study was carried out using quasi-experimental with pre-test and post-test design. The subjects of this study were outpatient ischemic stroke and the National Health Insurance (NHI) participant, age >18 years and had complete medication data. Prescribing data were compared between stroke patients treated at the hospital before and after implementation of CRS. The study was performed in 200 National Health Insurance (NHI) scheme outpatients with ischemic stroke. The groups consisted of 100 patients without CRS and 100 patients with CRS. The basic characteristics of both groups were similar. The results showed that after implementation of CRS, a significant improvement in the compliance of the neurologist prescribing medicine used to be available only in national formulary (RR: 1.02; 95% CI=1.00-1.04; p=0.015). Among others the most significant improvement was the prescription of antidyslipidemic using HMG-CoA medicine available in formulary. In conclusion, CRS can improve the compliance of prescribing with national formulary in stroke ischemic patients.
Hearing loss in pediatric patients with congenital rubella syndrome
Authors: Muyassaroh Muyassaroh , Rahmi Nisa Alifia
Published: May 2022

Congenital rubella syndrome (CRS) is caused by rubella infection in pregnant women. It was estimated 100.000 children with CRS, with 46% found in developing countries. The CRS consists of symptoms like sensorineural hearing loss (SNHL), congenital heart disease, cataract or congenital glaucoma, and other symptoms. Sensorineural hearing loss is the commonest symptoms compared with others. This study aimed to determine the hearing loss in CRS in Dr. Kariadi Central Hospital, Semarang, Central Java. This was a descriptive study using data from medical records from CRS pediatric patients who had BERA examination from January 2019 until December 2020. The CRS was characterized with one or more symptoms: SNHL, congenital cataract, congenital heart disease, and laboratory IgG and/or IgM Rubella (+). The SNHL was described from refer OAE result, tympanometry A, and BERA with hearing threshold ≥40 dB. Follow-up evaluation was performed with Google form questionnaire. There were 55 CRS cases with 70.9% had bilateral SNHL, mostly with very severe hearing loss. Normal hearing was found in 16 children (28.1%). From 30 children who were followed up, there were 20 children who had bilateral SNHL with 30% were moderate-severe degree and 70% profound. With further multidisciplinary management in children with CRS and parental support, 65% children used hearing aid and 40% had auditory-verbal therapy (AVT). Evaluation of the AVT showed progress in 30% children. In conclusion, SNHL is found in 70.9% children with CRS. Further management using hearing aid and AVT shows progress on few children.
Relationship between high-risk human papilloma virus (HPV) and subclinical condyloma acuminata (CA) in the cervix of high-risk women
Authors: Lumban Tobing Benjamin Ricardo Rubirosa , Hutapea Richard , Nadeak Kristina
Published: May 2022

Condyloma acuminata (CA) is a sexually transmitted infection (STI) caused by both high- and low risk human papilloma virus (HPV) infection. Subclinical CA looks like a white spot after an acetic acid test. High-risk women are women who have a high risk of STIs, including CA. The aim of this study was to evaluate the relationship between high-risk HPV and subclinical CA in the cervix of high-risk women. This was a cross-sectional analytic study involving 30 high-risk women. The age, the age at first sexual intercourse, the frequency of sexual intercourse, the number of sexual partners and the use of condoms were recorded. Subclinical CA was diagnosed by the 5% acetowhite test. HPV infection was detected by PCR. Kruskal Wallis test was conducted to evaluate the relationship between variables and the results were considered to be significant if p<0.05. The HPV infection was detected in 15 high-risk women with subclinical CA and most subjects showed the high-risk type. No significantly relationship between age and using of condom with high-risk HPV or with subclinical CA (p> 0.05). No significantly relationship between age at first sexual intercourse and frequency of sexual intercourse with high-risk HPV was also observed (p> 0.05), however, a significantly relationship with subclinical CA was observed (p < 0.05).  In conclusion, there is a relationship between high-risk HPV and subclinical CA in the cervix of high-risk women.
Antibiotic resistance of biofilm-producing bacteria from sepsis patients in Prof. Dr. Margono Soekarjo Hospital, Purwokerto, Central Java
Authors: Hestiyani Rani Afifah Nur , Siswandari Wahyu , Indriani Vitasari , Peramiarti I Dewa Sang Ayu Putu , Anjarwati Dwi Utami , Prihartini Hermin
Published: May 2022

Sepsis is a life-threatening organ dysfunction induced by the body's response to infection and is a significant cause of critical illness and death in hospitals. Bacteria are the most common pathogens that cause sepsis, and their ability to form biofilms increases their resistance to antibiotics. As a result of the failure of antibiotic administration therapy, the severity and pain of sepsis worsen. The study used a descriptive research design to determine the antibiotic resistance pattern of biofilm-producing bacteria from clinical isolates of sepsis patients. Using the BacT/Blood Culture System Alert, all patients suspected of sepsis in the intensive care unit of Prof. Dr. Margono Soekarjo General Hospital Purwokerto were examined for blood cultures between March and July 2018. These were then identified and tested for antibiotic resistance with the Vitek 2 Compact. Biofilm formation was detected utilizing the microtiter plate assay method, and the data were analyzed using a frequency distribution table. The results obtained 12 bacterial isolates, with Escherichia coli (41.67%), Staphylococcus haemolyticus (33.33%), Klebsiella pneumoniae ssp pneumoniae, Enterobacter cloacae complex, and Acinetobacter baumannii complex (8.33%) as the most common bacteria. All gram-negative bacteria (more than 80%) were resistant to ampicillin, cefoxitin, ceftazidime, ceftriaxone, aztreonam, and trimethoprim but were sensitive to meropenem (100%). Gram-positive bacteria were resistant to cefoxitin, benzylpenicillin, oxacillin, ciprofloxacin, erythromycin, and clindamycin (100% each). However, they were sensitive to tigecycline, nitrofuran, quinupristin, linezolid, vancomycin, and tetracycline (100% each). Gram-negative bacteria formed 50% biofilms, and 50% did not, whereas gram-positive bacteria produced 100% biofilms. In conclusion, bacteria clinical isolates of septic patients from Prof. Dr. Margono Soekarjo General Hospital Purwokerto are multiresistant to more than six types of antibiotics and produce weak to moderate biofilms, which can promote antibiotic resistance.
Challenge in diagnosing tuberculosis on a boy with severely wasted in limited resource area
Authors: Siagian Marini , Tanyadji Norman
Published: May 2022

Hunger and malnutrition are still the leading cause of morbidity and mortality among children around the world. Undernutrition increases the risk of tuberculosis (TB) which in turn could worsen undernutrition. Indonesia is currently the second highest newly diagnosed TB in the world after India. TB in children with severely wasted is difficult to diagnose. This is a case report about a 35-month-old boy with severely wasted complicated with hypoglycemia, severe dehydration, and pneumonia. After proper nutritional management without the expected outcome, patient was then worked up for TB resulting negative result of tuberculin skin test (TST). Nevertheless, he was still treated with antituberculosis and had significant improvement, hence continuation to complete 6 mo period of therapy. This case report describes the challenge of diagnosing TB in children with severely wasted in limited resource areas. The reduced immune responses, due to severely wasted, caused subtle clinical signs of TB and decreased sensitivity to tuberculin testing. The unavailability of radiologic examination added further problem in diagnosis. The diagnosis of TB should be considered among children in areas with a high prevalence of TB, presenting with severely wasted refractory to proper nutritional management.
Obesity and the role of genetic polymorphism: A review of genes as the risk of obesity
Authors: Hastuti Pramudji
Published: May 2022

Obesity can be caused by environmental factors, which are higher energy input or lower energy expenditure. Environmental factors supported by genetic factors cause a person to have a different risk for developing obesity from to another. Genetics factors cause obesity through several pathways, which are impaired regulation in the hypothalamus and the regulation of energy expenditure. Obesity may be caused by one gene as monogenic-associated obesity, however, commonly caused by several genes together with environmental factors as the main multi-factorial risk of obesity. Obesity causes inflammation which leads to metabolic diseases. Many efforts are performed to prevent or treat obesity through the intervention to environmental and or genetic factors. Many attempts to reduce the prevalence of obesity were performed by influencing the environmental risk factors or the genetic risk factors. In this review, we identified the main genes which influence obesity. The genetic risks of obesity may be different from one to another country or between ethnic groups. Therefore, a better treatment approach should consider the differences role of genes in obesity rather than only changes in lifestyle. Nutrigenetic approach by considering the difference role of gens in responding to nutrients or drugs is recommended in individualized treatment plans.
YY1 and NFYA: Potential tr-KIT Specific Transcription Factors in Prostate Cancer
Authors: ERGÜN Sercan , ARI Ferda , BENLİ Erdal , US ALTAY Diler , NOYAN Tevfik , ERDEM Havva , KAŞKO ARICI Yeliz
Published: May 2022

Objective: Via the use of an alternative promoter, a truncated c-KIT protein (tr-KIT) of 30-50 kDa is generated, lacking extracellular and transmembrane domains. Moreover, over-expression of tr-KIT, a stronger activator than c-KIT, appears to be specific to prostate cancer (PCa). Also, Imatinib, a tyrosine kinase inhibitor, blocks the activity of full-length c-KIT but has no effect on tr-KIT in PCa. Tr-KIT has its own nuclear factor binding site. However, the transcription factors (TFs) binding to this region specific to tr-KIT are not known yet. This study was conducted to define the most potential TFs specific for tr-KIT via in silico analysis.Methods: Tr-KIT potential TF binding sequence was uploaded into Tfsitescan database. Five TFs with the highest potential binding to this sequence were selected. Transcriptomic data of LNCaP (PCa expressing tr-KIT), PC3 (PCa not expressing tr-KIT) and RWPE-1 (normal prostate) cell lines (GSM1647378, GSE36022 and GSM738189, respectively) from Gene Expression Omnibus (GEO) database were compared for gene expression levels of pre-defined potential tr-KIT specific TFs using DESeq package of R-program. Finally, two TFs having higher expression levels in both LNCaP and PC3 compared to RWPE-1 and higher expression levels in LNCaP compared to PC3 were detected.Results: Five TFs having the highest potential were selected as: YY1, c-MYB, IL8, NFYA and TCF3. Via in silico analysis performed, it was found that YY1 and NFYA have the highest potential to be tr-KIT specific TFs in PCa, among them.Conclusion: YY1 and NFYA TFs may take a role in formation of tr-KIT in PCa.
Efficiency Determinants of Educational Wastage Programs
Authors: Alrashdan Hanadi , Al Ajmi Hadi Rashed , Alnasraween Mo’en Salman , Karra Sawsan
Published: May 2022

COVID-19 pandemic lockdowns converted traditional face-to-face teaching practices to online processes, resulting in thousands of students losing out on accessibility to education. The educational wastage program was introduced to enable students to recover their abilities and to improve their skills. The objective of this research is to study the determinants of such programs, including the inputs and the outputs. The teachers who participated in this program formed the population of this study; the random sample included 1500 teachers, both males and females. The collected questionnaire responses were downloaded into the SPSS software. The results show that time management is the most important factor that affects output of the recovery programs in educational wastage. The second factor that affects output of the recovery programs is the subjects introduced. Teachers’ participation in formulating such recovery programs is considered very important to improve output. The study recommends the participation of teachers in formulating recovery programs.
A Logistic Regression Model for Credit Risk of Companies in the Service Sector
Authors: Abid Lobna
Published: May 2022

Credit risk prediction is a vital issue in empirical studies as it has attracted the interests of many researchers. In the current study, a logistic regression model is used to evaluate determinants of payment default risks of companies in the service sector.Data, which consist of six financial variables and two macro-economic variables, have been collected from the Tunisian Central Bank and World Development Indicators.The obtained results show that debt, solvency and profitability ratios and a loan amount are the key firm-specific factor determining credit risk. Moreover, we further find that high level of inflation and the decrease of GDP growth rate are able to increase corporate credit risk.
Research and Analysis of Global Weather Extremes Affecting Civil Engineering Construction Schedules Based on LSTM Algorithm
Authors: Zhang Zhehua , Zhang Hao , Jiang Jun , Wang Xinyan
Published: May 2022

The occurrence of extreme weather events will cause serious harm to natural ecosystems, human social economy and construction sites. Large-scale construction projects have a long cycle and complex construction environment, and the schedule control is obviously disturbed by meteorological and other factors. Risk control of schedule delays is an important part of project risk management. The study of extreme weather events has become a key focus and hotspot in meteorological and climate science research in the context of global change. This paper proposes a more objective approach to defining extreme climate events from the study of extreme climate event uncertainty. On this basis, the spatial and temporal characteristics of extreme temperature and precipitation in recent decades are analysed. Considering the variability of precipitation and temperature, an idea is proposed to study extreme continuous precipitation events, and the mechanism of extreme precipitation occurrence in the region is explored. Finally, the LSTM model data are used to carry out studies and projections of changes in extreme climate events under different future scenarios.
SENDİKAL HAKLARIN HUKUKİ NİTELİĞİ
Authors: A. FANİD Nematollah (erdal)
Published: May 2022

Sendika ve ona bağlı olan hak ve özgürlükler, sermaye sahibi işveren karşısında zayıf bir konumda olan işçi sınıfının haklarını korumak için önemli bir hukuki müessesedir. Sendikanın işçi, işveren ve devlet olarak üç taraflı bir endüstri ilişkisinin oluşumudur. Bu ilişki, her ülkenin kendine özgü kültürel ve geleneksel yapılarına ve bulunduğu dönemin şartlarına bağlı olarak değişimler göstermektedir. Sendikalar, endüstri ilişkilerinin gelişmesiyle beraber hukuk sistemlerinin en önemli sivil toplum örgütleri haline gelmiştir. Sendika, işçi/işveren ve devletle olan ilişkide iş, kazanç ve toplumsal değerler bağlamında çıkarlarını korumak ve geliştirmek gayesiyle bir araya gelen örgütü tanımlamaktadır. Sanayi devrimi ile değişen çalışma şekli ve koşulları yeni düzene uyum sürecinde birtakım çatışmaları beraberinde getirmiştir. Çalışmanın temel amacı 1982 Anayasası’nda öngörülen sendikal hakların hukuki niteliğinin araştırılmasıdır. Bu makale, Türkiye’de sendikal hakların geçmişteki ve günümüzdeki hukuki gelişmelerini AB ülkeleri ile karşılaştırmalı olarak incelemeye alarak konuyla ilgili mevzuat ve mevcut uygulamaları Avrupa standartlarıyla karşılaştırmıştır.
Emerging learning environment: Escola da Ponte
Authors: Pereira Bárbara Rubina Coelho Ramos , Brazão José Paulo Gomes
Published: May 2022

This article aims to question the pedagogical modes of action within the contexts, from a perspective of rupture with the institutionalized model of teaching-learning. It is important to take a close look at critical constructivism, exposing its relationship with emerging learning environments and with pedagogical innovation. We proceed to the presentation of the learning environment present at Escola da Ponte, looking at it as an emergent learning environment in the light of critical constructivism. We conclude that the Fazer a Ponte project is a new pedagogy, which presents itself as disruptive in relation to traditional practices associated with the factory school model, which fosters the development of student skills, namely the capacity for reflection and evaluation, critical thinking and problem solving.
Hypertext in language teaching and learning: a bibliometric study
Authors: Santos Flávia Cacho dos , Galvão Nadielli Maria dos Santos
Published: May 2022

Powered by digital, hypertext has brought about changes in reading and writing in the information society. With its links, it enables navigation in the "ocean" of ideas, requiring adequate knowledge to navigate.  Incomprehension and textual abandonment are consequences that scholars report and that we need to discuss. About them, we highlight Lévy (2011), Marcuschi and Xavier (2010), Castells (2020), Schuab (2016), Schnneider and Carvalho (2018), important authors in the discussion about technology and education. In this paper, we focused on analyzing the need for the debate on hypertext in language teaching-learning with a bibliometric research, whose goal is to provide a broad mapping of a subject, serving as a support for new studies. We obtained, as a result, the idea that hypertext is an area of research evident in developed countries and in need of current research.
Between the musealized memories and the elderly people’s memories of “Pão de Santo Antônio”: thoughts on the elder people’s memories in a decolonial perspective
Authors: Silva Guilherme Henrique da , Lucini Marizete
Published: May 2022

This article’s main goal is to present thoughts about a research the elderly people’s memories who lives in asylums in a phenomenological-hermeneutic approach. Therefore, we place the context in which the elderly people living in asylums, In this case,Pão de Santo Antônio asylum, Along with the Santo Antônio Typography Museum and the Voz de Diamantina Newspaper, Shapes the “Pão de Santo Antônio” Association complex, formerly called “Recolhimento dos Pobres de Pão de Santo Antônio”, in Diamantina, Minas Gerais, showing its invisibility through the production of institutionalized memories. We also propose a listening/interpretation of these subjects' narratives as a possibility of knowing other stories that break with the colonized perspective which contributes to the silencing of other’s histories, through a phenomenological approach. Finally, It is highlighted the potential for further inquiries that enable the emergence of other human stories opposed to the institutionalized memory.
PHOLIDOTA CHINENSIS ALLEVIATES AZOXYMETHANE/DEXTRAN SULFATE SODIUM-INDUCED COLORECTAL CARCINOGENESIS THROUGH INHIBITION OF TLR4 AND COX-2
Authors: Liu Li-Long , Xu Kai , Kang Lu-Mei , Jiang Shu-Ping , Wang Qing-Hua , Zhang Lei , Wan Shao-Gui , Chen Hongping
Published: May 2022

Inflammatory bowel disease (IBD) always progresses to colorectal cancer (CRC) which is the second most frequent cause of death by cancer. It is about

2% of population in the lifetime worldwide who at the risk for development of CRC. Oxaliplatin is an effective anticancer drug used for the treatment of advanced CRC, however, it always causes a robust painful neuropathy. Pholidota chinensis is a Chinese folk herbal medicine which was used for treatment of inflammation such as gastroenteritis, duodenal ulcer and bronchitis. In the present study, we examined the role of Pholidota chinensis in inflammation-related colon tumorigenesis which was induced by azoxymethane (AOM)/dextran sulfate sodium (DSS) in mice. We found that Pholidota chinensis can alleviate the colon tumorigenesis. The prevention effects of Pholidota chinensis is similar to oxaliplatin. Specifically, administration of Pholidota chinensis solution suppresses the expression of the proliferating cell nuclear antigen (PCNA), toll-like receptor 4 (TLR4) and cyclooxygenase-2 (COX-2). Our findings suggested that Pholidota chinensis participate in the regulation of colon cancer development through inhibiting the expression of TLR4 and COX-2.
POTENTIALS OF SOME PLANT-DERIVED FOODS IN THE MANAGEMENT OF DIABETES AND ASSOCIATED COMPLICATIONS
Authors: Ogunyinka Bolajoko Idiat , Oyinloye Babatunji Emmanuel , Adenowo Abiola Fatimah , Kappo Abidemi Paul
Published: May 2022

Background and Objective: Diabetes is an insidious as well as a debilitating metabolic disease with variety of causes that could lead to severe

complications in multiple organs within the body system. There has been no documented scientific evidence as regards total cure of this complex

chronic disease; therefore, it demands a lifelong management. This has necessitated the recent evaluation of several plant derived foods as costeffective

alternatives in the management of diabetes and its associated complication.

Materials and Methods: This review is based on integration of information from multi-databases after a comprehensive literature search on the

various plant derived foods that have been reported to have shown a certain degree of amelioration in the management of diabetes and diabetic

complications.

Result and Discussion: Published reports suggest that oxidative stress primarily mediated by uncontrolled hyperglycemia play a pivotal role in the

pathogenesis of diabetes and its associated complications. Therefore, various plant-derived foods are believed to delay, prevent or manage diabetes

and its associated complications using different mechanisms which could be established through their potential to increase insulin sensitivity, free

radicals scavenging abilities, hypolipidemic, hypoglycaemic, hypocholesterolemic, antioxidative, anti-inflammatory and inhibition of α-amylase and

α-glucosidase activities.

Conclusion: Based on the evidence presented in this review, plant-derived foods possess bioactive constituents believed to be rich in antioxidants

and proteins which may be responsible for their mode of actions; we propose that Cucuma longa (curcumin), Garcinia kola (kolaviron), Telfairia

occidentalis and Parkia biglobosa be explored in the management of diabetes and its associated complications due to their outstanding beneficial

effects.
PTEROCARPUS ANGOLENSIS CRUDE EXTRACTS INDUCE THE EXPRESSION OF COLLAGEN TYPE II IN ARTICULAR CARTILAGE IN VITRO
Authors: Ssemakalu Cornelius Cano , Razwinani Mapula , Maepa Makwese Johannes , Motaung Keolebogile Shirley
Published: May 2022

Background: Pterocarpus angolensis (P. angolensis) is a large deciduous tree native to Sub-Saharan Africa. This tree has

traditionally been used to treat malaria, gonorrhoea, inflammation and wounds. The use of P. angolensis for tissue

engineering has not been explored. This study investigated the potential of the bark and root water extracts of P. angolensis

to induce the expression of collagen type II protein in the articular chondrocytes.

Materials and Methods: Surface and middle zone chondrocytes, as well as explants, were stimulated with crude root and

bark plant extracts at different concentrations. After 96 hours of stimulation, microscopic observation, XCELLigence assay

and collagen type II ELISA, histology and immunohistochemistry assays were done.

Results and Conclusion: Results showed no significant difference in the cell index between the controls and chondrocytes

that had been treated with the plant extracts at concentrations of 15 and 30 μg/ml. A significant increase in the expression of

collagen type II protein by the chondrocytes was observed and found to be optimal at a concentration of 30 μg/ml. There was

an increase in the production of proteoglycans. However, the plant extracts at a concentration of 50 μg/ml induced apoptosis

in the middle zone chondrocytes. These results show the potential of P. angolensis extracts in chondrocyte tissue

regeneration. This potential could be exploited in the treatment of osteoarthritis.
ANTI-TUMOR EFFECTS OF EPHEDRINE AND ANISODAMINE ON SKBR3 HUMAN BREAST CANCER CELL LINE
Authors: Chen Dan , Ma Feng , Liu Xiao-hui , Cao Rui , Wu Xiong-Zhi
Published: May 2022

Background: To investigate the effects of ephedrine and anisodamine on the proliferation of human breast cancer.

Materials and Methods: SKBR3 cell was treated with or without ephedrine and / or anisodamine, respectively. The trypan blue exclusion assay was

used to determine cell numbers. Flow cytometry was used to assess cell cycle distribution and apoptosis. The concentration of cAMP and cyclin D1

was analyzed by enzyme-linked immunosorbent assay. Western blot was used to measure PKA.

Results: Ephedrine and anisodamine inhibited cell proliferation and arrested SKBR3 cells at G0/G1 phases. Ephedrine and anisodamine increased the

level of CD1 in SKBR3 cells. Furthermore, significant change in intracellular cAMP concentration was found in SKBR3 cells treated with ephedrine

and anisodamine. The phosphorylation of PKA substrate was not activated after 48 hours of treatment with ephedrine and anisodamine.

Conclusion: Ephedrine and anisodamine inhibit the proliferation of SKBR3 cells via a significantly change of intracellular cAMP concentration.
FOLIAR MICROMORPHOLOGY OF LIPPIA JAVANICA (BURM.F) SPRENG
Authors: Asowata-Ayodele Abiola Mojisola , Afolayan Anthony Jide , Otunola Gloria Aderonke
Published: May 2022

Background: Lippia javanica (Burm.F.) Spreng is an aromatic indigenous South African plant with culinary and medicinal values.

This study investigated the foliar morphology and elemental composition of the plant because not much data concerning the

anatomical and micro-morphological features can be found in literature

Materials and Methods: Fresh leaves of the plant were investigated using light and scanning electron microscopy (SEM). The

elemental composition of the leaf was determined by energy dispersive X-ray spectroscopy.

Results: The leaves of L. javanica were amphitrichomic while the stomata distribution was amphistomatic. These stomata were

more or less randomly distributed over the epidermis lying almost close to each other and were fewer in number in between the veins

and over the finer veins. The major constituents of crystals found in the plant were Ca, Na, S, Al, P, Cl, K, Mg and Fe. The presence

of long glandular trichomes on the leaf surfaces of the plant could indicate secretory sites where secondary metabolites are produced.

Conclusion: Secretions from the glandular trichomes and the presence of these elements, which are vital in maintaining good health,

are probably responsible for the culinary and medicinal properties of L. javanica.
THE EFFECTS OF EXTRACTS OF ATRACTYLODES MACROCEPHALA KOIDZ COMBINED WITH TRANSCUTANEOUS ELECTRICAL ACUPOINT STIMULATION IN TREATING THE OVARIECTOMIZED FEMALE RATS
Authors: Weng Qing , Cao Zhu-Feng , Yu Yan-Wen , Lv Xiang-Lin , Qu Fan , Zhou Jue
Published: May 2022

Background: The present study was to explore the effects of the extracts of Atractylodes macrocephala Koidz (EAMK) combined

with transcutaneous electrical acupoint stimulation (TEAS) on the ovariectomized female rats.

Materials and Methods: Forty female Sprague-Dawley rats were randomly divided into four groups: sham-operation, model, livial

and EAMK+TEAS groups (n=10 in each group). After the individual treatments for 8 weeks ended, the serum levels of estradiol

(E2), follicle stimulating hormone (FSH), luteinizing hormone (LH), osteocalcin and interleukin-6 (IL-6) were measured with

commercial enzyme-linked immunosorbent assay.

Results: We found that in the sham-operation group, the serum E2 and osteocalcin levels were significantly higher, and the serum

levels of FSH, LH and IL-6 were markedly lower than those of other groups (P0.05), however, the serum FSH and IL-6 levels of

EAMK+TEAS group were significantly lower than those of the livial group (P
CURATIVE CARE THROUGH ADMINISTRATION OF PLANT-DERIVED MEDICINES IN SEKHUKHUNE DISTRICT MUNICIPALITY OF LIMPOPO PROVINCE, SOUTH AFRICA
Authors: Rankoana Agnes Sejabaledi
Published: May 2022

Background: Ajuga bracteosa and Viola odorata are frequently used by the native people of Swat-Pakistan for the curing of fever,

malaria, cough, urinary and stomach disorders with slightly different practice of usage like raw powdered, extracts, decoction etc.

Methods and Materials: Disc Diffusion Method was used for determination of antimicrobial activities of both plants. Nutrient Agar

Media was used for the culturing and growth of all microbial strains. Vitamin C and minerals contents were determined by standard

method of AOAC. Na and K were analyzed by using flame photometric technique. Micro minerals i.e. “Ni, Cr, Fe, Cu, Zn, Mn, Ca, Pb,

and Mg” were determined by Atomic Absorption Spectrophotometer (AAS). Total Soluble Solid (TSS) was determined by using abbe

refractometer and pH was determined by using pH meter.

Results: The present study demonstrates that both plants exhibited antibacterial activities against P. aeruginos, E. coli, S. typhi, B.

subtilis and S. aureus. The examined plants showed zone of inhibition for aqueous fraction (50.90, 45.90 %) against P. aeruginosa; for

EtOAc fraction (41.37, 57.62%) against C. Albicans and for hexane fraction (25.86, 40.57%) against K. pneumoniae, respectively. Total

of 14 different minerals (Na, K, P, Ca, Mg, Fe, Zn, Mn, Co, Cr, Ni, Cu, Pb, Cd) were determined and it was also observed that both the

examined plants contained significant level of these analyzed minerals. The subject plants contained highest level of magnesium (295.75,

145.85 mg 100-1g) and calcium (212.49, 44.00 mg 100-1g) and potassium (152.6, 437.45 mg 100-1g) while moderate level P, Zn, Na and

lower amount of Cd, Ni, Mn and Cu using Atomic Absorption, Flame Photometry and spectrophotometric techniques. V. odorata was

found to contain a higher amount of vitamin C (64.05±12.37mg 100-1g) as compared to A. bracteosa (45.45 ± 7.29 mg 100-1 g).

Conclusion: Findings of this study can persuade researchers for future comprehensive phytochemical study of these plants using state of

art techniques and instruments, which include not only isolation of secondary metabolites from these plants but biological evaluation of

isolated compounds both in vivo and in vitro