bluuebunny/crossref_metadata_2025 huggingface dataset:
Causes for the Occurrence of Severe Drought at the Ogasawara (Bonin) Islands during the El Niño Event in 2018–2019
Authors: Matsuyama Hiroshi
Published: August 2024

The Ogasawara (Bonin) Islands, consisting of more than 30 islands and located approximately 1000 km south of central Tokyo, occasionally experience severe droughts. Severe drought does not typically occur during El Niño (EN) events in the Ogasawara Islands because convective activity around the tropical western Pacific is inactive during EN events and correspondingly induces substantial precipitation around the Ogasawara Islands through the Pacific–Japan (P-J) pattern. However, a severe drought in 2018–2019 occurred during EN. In this study, we investigated the causes of drought occurrence. In 2018–2019, the El Niño Modoki (EN Modoki) event occurred simultaneously with EN, which decreased precipitation around the Ogasawara Islands from autumn to the following spring. This was induced by the positive sea level pressure anomaly and anticyclonic circulation around the Ogasawara Islands peculiar to the EN Modoki condition. In relation to the 2018–2019 drought, the investigation of past drought events at the Ogasawara Islands revealed that the drought in the spring and summer of 1991 also occurred during the simultaneous occurrence of the EN and EN Modoki events.
Detection of Optogalvanic Spectra Using Driven Quasi-Periodic Oscillator Dynamics
Authors: Koepke Mark
Published: August 2024

The narrowband light from a scannable, single-mode dye laser influences the electrical properties of gas discharges. The variation in these properties as the laser wavelength λ is scanned yields the optogalvanic spectrum of the discharge (i.e., electrical conductivity vs. frequency). By connecting a neon lamp, capacitor, and power supply in parallel, an undriven relaxation oscillator is formed whose natural frequency f0 is affected by neon-resonant laser light and this λ-dependence of the relaxation oscillator frequency f0 yields a variant optogalvanic spectrum (i.e., f0 vs. frequency). In this paper, a driving force is effectively applied to an otherwise undriven oscillator when the incident light is chopped periodically at fd. For fd ≈ f0 and a sufficiently large driving force amplitude (laser intensity and the degree of neon resonance), the relaxation oscillator can be entrained so that f0 is locked on fd and is independent of λ. For the new chopped-light technique described here, fd is adjusted to be the subthreshold of the entrainment range, where the λ-dependence of f0 is advantageously exaggerated by periodic pulling, and the beat frequency |fd − f0| vs. λ provides an optogalvanic spectrum with appealingly amplified signal-to-noise qualities. Beat frequency neon spectra are reported for the cases fd < f0 and fd > f0 and are compared with spectra obtained using the unchopped-light (i.e., undriven) method.
Feasibility of Stationary Cycling with Pedal Force Visual Feedback Post-Total Knee Arthroplasty: Implications for Inter-Limb Deficits in Knee Joint Biomechanics
Authors: Hummer Erik T. , Porter Jared , Cates Harold , Zhang Songning
Published: August 2024

The purpose of this study was to assess the biomechanical adaptations prompted by stationary cycling paired with visual feedback of vertical pedal reaction forces during both stationary cycling and overground walking for patients who underwent a total knee arthroplasty (TKA). Specifically, an emphasis on the inter-limb deficits in knee joint biomechanics were examined. Ten patients who underwent a TKA took part in an acute intervention with pre- and post-testing measurements of kinematics (240 Hz) and kinetics (1200 Hz) during stationary cycling and overground walking. The intervention phase consisted of six cycling sessions during which participants were provided with visual feedback of their bilateral peak vertical pedal reaction force, with instructions to maintain a symmetrical loading between limbs. A 2 × 2 (work rate/speed × time) repeated measures ANOVA (α = 0.05) was conducted on key outcome variables. Peak knee extension moment asymmetry during stationary cycling significantly improved (p = 0.038, η2p = 0.610) following the acute intervention. Walking velocities for both preferred (p = 0.001, d = 0.583) and fast (p = 0.002, d = 0.613) walking speeds displayed improvements from pre- to post-testing. Significant improvements in the total score (p = 0.009, d = 0.492) and ADL subscale score (p = 0.041, d = 0.270) for the Knee Injury and Osteoarthritis Outcome Score were present following the acute intervention. Stationary cycling with visual feedback may be beneficial post-TKA; however, further investigation is merited.
Deciphering Depression: Epigenetic Mechanisms and Treatment Strategies
Authors: Aljabali Alaa A. A. , Alkaraki Almuthanna K. , Gammoh Omar , Tambuwala Murtaza M. , Mishra Vijay , Mishra Yachana , Hassan Sk. Sarif , El-Tanani Mohamed
Published: August 2024

Depression, a significant mental health disorder, is under intense research scrutiny to uncover its molecular foundations. Epigenetics, which focuses on controlling gene expression without altering DNA sequences, offers promising avenues for innovative treatment. This review explores the pivotal role of epigenetics in depression, emphasizing two key aspects: (I) identifying epigenetic targets for new antidepressants and (II) using personalized medicine based on distinct epigenetic profiles, highlighting potential epigenetic focal points such as DNA methylation, histone structure alterations, and non-coding RNA molecules such as miRNAs. Variations in DNA methylation in individuals with depression provide opportunities to target genes that are associated with neuroplasticity and synaptic activity. Aberrant histone acetylation may indicate that antidepressant strategies involve enzyme modifications. Modulating miRNA levels can reshape depression-linked gene expression. The second section discusses personalized medicine based on epigenetic profiles. Analyzing these patterns could identify biomarkers associated with treatment response and susceptibility to depression, facilitating tailored treatments and proactive mental health care. Addressing ethical concerns regarding epigenetic information, such as privacy and stigmatization, is crucial in understanding the biological basis of depression. Therefore, researchers must consider these issues when examining the role of epigenetics in mental health disorders. The importance of epigenetics in depression is a critical aspect of modern medical research. These findings hold great potential for novel antidepressant medications and personalized treatments, which would significantly improve patient outcomes, and transform psychiatry. As research progresses, it is expected to uncover more complex aspects of epigenetic processes associated with depression, enhance our comprehension, and increase the effectiveness of therapies.
Neglected Tropical Diseases: A Chemoinformatics Approach for the Use of Biodiversity in Anti-Trypanosomatid Drug Discovery
Authors: Valli Marilia , Döring Thiago H. , Marx Edgard , Ferreira Leonardo L. G. , Medina-Franco José L. , Andricopulo Adriano D.
Published: August 2024

The development of new treatments for neglected tropical diseases (NTDs) remains a major challenge in the 21st century. In most cases, the available drugs are obsolete and have limitations in terms of efficacy and safety. The situation becomes even more complex when considering the low number of new chemical entities (NCEs) currently in use in advanced clinical trials for most of these diseases. Natural products (NPs) are valuable sources of hits and lead compounds with privileged scaffolds for the discovery of new bioactive molecules. Considering the relevance of biodiversity for drug discovery, a chemoinformatics analysis was conducted on a compound dataset of NPs with anti-trypanosomatid activity reported in 497 research articles from 2019 to 2024. Structures corresponding to different metabolic classes were identified, including terpenoids, benzoic acids, benzenoids, steroids, alkaloids, phenylpropanoids, peptides, flavonoids, polyketides, lignans, cytochalasins, and naphthoquinones. This unique collection of NPs occupies regions of the chemical space with drug-like properties that are relevant to anti-trypanosomatid drug discovery. The gathered information greatly enhanced our understanding of biologically relevant chemical classes, structural features, and physicochemical properties. These results can be useful in guiding future medicinal chemistry efforts for the development of NP-inspired NCEs to treat NTDs caused by trypanosomatid parasites.
Enhancing Vaccine Efficacy and Stability: A Review of the Utilization of Nanoparticles in mRNA Vaccines
Authors: Parvin Nargish , Joo Sang Woo , Mandal Tapas Kumar
Published: August 2024

The development of vaccines has entered a new era with the advent of nanotechnology, particularly through the utilization of nanoparticles. This review focuses on the role of nanoparticles in enhancing the efficacy and stability of mRNA vaccines. Nanoparticles, owing to their unique properties such as high surface area, tunable size, and their ability to be functionalized, have emerged as powerful tools in vaccine development. Specifically, lipid nanoparticles (LNPs) have revolutionized the delivery of mRNA vaccines by protecting the fragile mRNA molecules and facilitating their efficient uptake by cells. This review discusses the various types of nanoparticles employed in mRNA vaccine formulations, including lipid-based, polymer-based, and inorganic nanoparticles, highlighting their advantages and limitations. Moreover, it explores the mechanisms by which nanoparticles improve immune responses, such as enhanced antigen presentation and the prolonged release of mRNA. This review also addresses the challenges and future directions in nanoparticle-based vaccine development, emphasizing the need for further research to optimize formulations for broader applications. By providing an in-depth analysis of the current advancements in and potential of nanoparticles in mRNA vaccines, this review aims to shed light on their critical role in combating infectious diseases and improving public health outcomes.
In Vivo Prevalence of Beta-Amyloid Pathology and Alzheimer’s Disease Co-Pathology in Idiopathic Normal-Pressure Hydrocephalus—Association with Neuropsychological Features
Authors: Pyrgelis Efstratios-Stylianos , Paraskevas George P. , Constantinides Vasilios C. , Boufidou Fotini , Stefanis Leonidas , Kapaki Elisabeth
Published: August 2024

Idiopathic normal-pressure hydrocephalus (iNPH) is a clinic-radiological neurological syndrome presenting with cognitive deficits, gait disturbances and urinary incontinence. It often coexists with Alzheimer’s disease (AD). Due to the reversible nature of iNPH when promptly treated, a lot of studies have focused on possible biomarkers, among which are cerebrospinal fluid (CSF) biomarkers. The aim of the present study was to determine the rate of beta-amyloid pathology and AD co-pathology by measuring AD CSF biomarkers, namely, amyloid beta with 42 and 40 amino acids (Aβ42), the Aβ42/Aβ40 ratio, total Tau protein (t-Tau) and phosphorylated Tau protein at threonine 181 (p-Tau), in a cohort of iNPH patients, as well as to investigate the possible associations among CSF biomarkers and iNPH neuropsychological profiles. Fifty-three patients with iNPH were included in the present study. CSF Aβ42, Aβ40, t-Tau and p-Tau were measured in duplicate with double-sandwich ELISA assays. The neuropsychological evaluation consisted of the Mini-Mental State Examination, Frontal Assessment Battery, Five-Word Test and CLOX drawing tests 1 and 2. After statistical analysis, we found that amyloid pathology and AD co-pathology are rather common in iNPH patients and that higher values of t-Tau and p-Tau CSF levels, as well as the existence of the AD CSF profile, are associated with more severe memory impairment in the study patients. In conclusion, our study has confirmed that amyloid pathology and AD-co-pathology are rather common in iNPH patients and that CSF markers of AD pathology and t-Tau are associated with a worse memory decline in these patients.
Diabetes and Its Impact on Cardiogenic Shock Outcomes in Acute Myocardial Infarction with Polyvascular Disease: A Comparative Analysis
Authors: Gatuz Marlon V. , Abu-Fanne Rami , Abramov Dmitry , Mamas Mamas A. , Roguin Ariel , Kobo Ofer
Published: August 2024

Background: Diabetes mellitus (DM) significantly impacts cardiovascular outcomes, particularly in patients with acute myocardial infarction (AMI) complicated by cardiogenic shock (CS). The presence of polyvascular disease further complicates the prognosis due to the increased burden of atherosclerosis and comorbidities. This study was designed to investigate the combined impact of DM and polyvascular disease on outcomes in patients with AMI and CS. Method: Using the National Inpatient Sample database, we analyzed 39,140 patients with AMI complicated by CS and known polyvascular disease. The patients were stratified by diabetes status. The study assessed in-hospital major adverse cardiovascular and cerebrovascular events (MACCE), mortality, cerebrovascular accident (CVA) and major bleeding. Multivariable logistic regression models were used to examine the association between in-hospital outcomes and diabetes, adjusting for baseline differences. Results: Of the study population, 54% had DM. The patients with DM were younger (69.5 vs. 72.1 years, p < 0.001) and more likely to be female (36.7% vs. 34.2%, p < 0.001). After adjustment, the patients with DM showed a 17% increased mortality risk (aOR 1.17, 95% CI: 1.11–1.23, p < 0.001) and a higher risk of major adverse cardiovascular and cerebrovascular events (aOR 1.05, 95% CI: 1.01–1.10, p = 0.020). Conclusions: DM significantly impacts outcomes in patients with AMI complicated by CS and polyvascular disease, leading to increased mortality risk, longer hospital stays, and higher healthcare costs. These findings underscore the need for targeted interventions and specialized care strategies for this high-risk population.
Impact of Urethral Sphincter Electrophysiology on Botulinum Toxin A Treatment in Women with Non-Neurogenic Dysfunctional Voiding
Authors: Chang Tien-Lin , Jiang Yuan-Hong , Kuo Hann-Chorng
Published: August 2024

Dysfunctional voiding (DV) is an abnormal urethral sphincter activity during voiding in neurologically normal individuals. Urethral sphincter botulinum toxin A (BoNT-A) injection has been used to treat DV, but the results have not been completely satisfactory. This study investigated the neurological characteristics of women with DV using the lower urinary tract electrophysiology (EP) study and the therapeutic efficacy of BoNT-A injection. In total, 48 women with DV and 16 women with normal voiding were included. Videourodynamic studies were conducted to diagnose DV before BoNT-A injection. EP studies, including urethral sphincter electromyography, bulbocavernosus reflex, and pudendal nerve conduction velocity, were conducted. Polyphasic motor unit action potentials suggestive of reinnervation were detected in 58.3% of patients with DV and 18.8% of controls (p = 0.001). Significant improvement in the corrected maximum flow rate (cQmax) was observed in patients with reinnervation at 1 and 3 months after BoNT-A injections into the urethral sphincter. Urethral sphincter denervation or reinnervation activity was commonly noted in 62.5% of women with DV. Repeated BoNT-A injections into the urethral sphincter provided effective treatment in 47.9% of patients, with mild improvement in cQmax observed in patients with urethral sphincter reinnervation. However, the improvement was not superior to those without reinnervation.
Growth Factors and Their Application in the Therapy of Hereditary Neurodegenerative Diseases
Authors: Issa Shaza , Fayoud Haidar , Shaimardanova Alisa , Sufianov Albert , Sufianova Galina , Solovyeva Valeriya , Rizvanov Albert
Published: August 2024

Hereditary neurodegenerative diseases (hNDDs) such as Alzheimer’s, Parkinson’s, Huntington’s disease, and others are primarily characterized by their progressive nature, severely compromising both the cognitive and motor abilities of patients. The underlying genetic component in hNDDs contributes to disease risk, creating a complex genetic landscape. Considering the fact that growth factors play crucial roles in regulating cellular processes, such as proliferation, differentiation, and survival, they could have therapeutic potential for hNDDs, provided appropriate dosing and safe delivery approaches are ensured. This article presents a detailed overview of growth factors, and explores their therapeutic potential in treating hNDDs, emphasizing their roles in neuronal survival, growth, and synaptic plasticity. However, challenges such as proper dosing, delivery methods, and patient variability can hinder their clinical application.
The Sigma-1 Receptor Exacerbates Cardiac Dysfunction Induced by Obstructive Nephropathy: A Role for Sexual Dimorphism
Authors: Munguia-Galaviz Francisco Javier , Miranda-Diaz Alejandra Guillermina , Gutierrez-Mercado Yanet Karina , Ku-Centurion Marco , Gonzalez-Gonzalez Ricardo Arturo , Portilla-de Buen Eliseo , Echavarria Raquel
Published: August 2024

The Sigma-1 Receptor (Sigmar1) is a stress-activated chaperone and a promising target for pharmacological modulation due to its ability to induce multiple cellular responses. Yet, it is unknown how Sigmar1 is involved in cardiorenal syndrome type 4 (CRS4) in which renal damage results in cardiac dysfunction. This study explored the role of Sigmar1 and its ligands in a CRS4 model induced by unilateral ureteral obstruction (UUO) in male and female C57BL/6 mice. We evaluated renal and cardiac dysfunction markers, Sigmar1 expression, and cardiac remodeling through time (7, 12, and 21 days) and after chronically administering the Sigmar1 agonists PRE-084 (1 mg/kg/day) and SA4503 (1 mg/kg/day), and the antagonist haloperidol (2 mg/kg/day), for 21 days after UUO using colorimetric analysis, RT-qPCR, histology, immunohistochemistry, enzyme-linked immunosorbent assay, RNA-seq, and bioinformatics. We found that obstructive nephropathy induces Sigmar1 expression in the kidneys and heart, and that Sigmar1 stimulation with its agonists PRE-084 and SA4503 aggravates cardiac dysfunction and remodeling in both sexes. Still, their effects are significantly more potent in males. Our findings reveal essential differences associated with sex in the development of CRS4 and should be considered when contemplating Sigmar1 as a pharmacological target.
Lymphocytic Myocarditis in Children with Parvovirus B19 Infection: Pathological and Molecular Insights
Authors: Pelzl Lisann , Mantino Sabrina , Sauter Martina , Manuylova Tatiana , Vogel Ulrich , Klingel Karin
Published: August 2024

Background: This study aims to evaluate the role of parvovirus B19 (B19V) in the pathogenesis of myocarditis in a paediatric population, including post-mortem samples from two children. Methods: From 2004 to 2023, endomyocardial biopsies (EMBs) from children under 16 years of age were analyzed using histology, immunohistochemistry, and molecular pathology. A total of 306 children with acute and 1060 children with chronic lymphocytic myocarditis were identified. Results: B19V infection was more frequent in acute myocarditis than in chronic myocarditis (43% vs. 14%), with higher viral loads in acute cases regardless of age. The most prominent cardiac CD3+ T cell infiltration was noted in children < 2 years, correlating with high cardiac B19V loads. In two male infants who died from B19V infection, B19V DNA was localized in the endothelial cells of multiple organs using in situ hybridization. Virus replication was found in the endothelial cells of small cardiac arterioles and venules but not in capillaries. B19V DNA/mRNA was also detected in immune cells, especially in the spleen and lymph nodes, revealing virus replication in B lymphocytes. Conclusions: B19V can induce severe lymphocytic myocarditis, especially in young children. The simultaneous histopathological and molecular assessment of EMBs is important for early diagnosis of viral myocarditis, preventing severe disease, and ensuring appropriate therapy.
Clinical Evaluation of Adrenal Incidentaloma: The Experience of a Referral Center
Authors: Petramala Luigi , Circosta Francesco , Marino Luca , Palombi Edoardo , Costanzo Maria Ludovica , Servello Adriana , Galardo Gioacchino , Letizia Claudio
Published: August 2024

The number of adrenal incidentaloma (AI) cases has increased in the last few years due to the widespread use of imaging diagnostics. Management requires evaluation of the malignant nature and hormonal activity. The aim of the present study is to assess possible clinical abnormalities in 132 AI patients both at baseline and during follow-up (mean 48.6 ± 12.5 months). In all patients, demographic, anthropometric data, biochemical, metabolic and hormonal data, and 24-h ambulatory blood pressure monitoring were assessed. Mild autonomous cortisol secretions (MACS) were diagnosed in patients without signs and symptoms of overt Cushing’s syndrome and post dexamethasone (DXM) plasma cortisol concentration > 50 nmol/L (>1.8 μg/dL). Patients with overnight DXM-1 mg test positive showed higher values of diastolic blood pressure, glycemia and uric acid levels compared to patients with negative DXM test at baseline. During follow-up, the potential development of MACS in patients with nonfunctional AI showed a prevalence of 29%, though the cardiovascular and metabolic alterations were less pronounced compared to those diagnosed with MACS at baseline. Therefore, follow-ups with AI patients are useful for observing changes in clinical features.
Navigating Complexity in Postural Orthostatic Tachycardia Syndrome
Authors: Qu Hui-Qi , Hakonarson Hakon
Published: August 2024

Postural Orthostatic Tachycardia Syndrome (POTS) affects up to 1% of the US population, predominantly women, and is characterized by a complex, elusive etiology and heterogeneous phenotypes. This review delves into the intricate physiology and etiology of POTS, decoding the roles of the sinoatrial node, the autonomic nervous system, fluid dynamics, and the interplay between the immune and endocrine systems. It further examines key contributing factors such as dysautonomia, thoracic hypovolemia, autonomic neuropathies, sympathetic denervation, autoimmune responses, and associations with conditions such as small-fiber neuropathy and mast cell activation syndrome. Given the numerous mysteries surrounding POTS, we also cautiously bring attention to sinoatrial node and myocardial function, particularly in how the heart responds to stress despite exhibiting a normal cardiac phenotype at rest. The potential of genomic research in elucidating the underlying mechanisms of POTS is emphasized, suggesting this as a valuable approach that is likely to improve our understanding of the genetic underpinnings of POTS. The review introduces a tentative classification system for the etiological factors in POTS, which seeks to capture the condition’s diverse aspects by categorizing various etiological factors and acknowledging co-occurring conditions. This classification, while aiming to enhance understanding and optimize treatment targets, is presented as a preliminary model needing further study and refinement. This review underscores the ongoing need for research to unravel the complexities of POTS and to develop targeted therapies that can improve patient outcomes.
Effects of Resistant-Starch-Encapsulated Probiotic Cocktail on Intestines Damaged by 5-Fluorouracil
Authors: Wang Jui-Ling , Yeh Chin-Hsing , Huang Shih-Hung , Wu Lawrence Shih-Hsin , Chen Miles Chih-Ming
Published: August 2024

Probiotics and prebiotics have gained attention for their potential health benefits. However, their efficacy hinges on probiotic survival through the harsh gastrointestinal environment. Microencapsulation techniques provide a solution, with resistant starch (RS)-based techniques showing promise in maintaining probiotic viability. Specifically, RS-encapsulated probiotics significantly improved probiotic survival in gastric acid, bile salts, and simulated intestinal conditions. This study investigated the effects of a resistant-starch-encapsulated probiotic cocktail (RS-Pro) in the context of 5-fluorouracil (5-FU) chemotherapy, which frequently induces microbiota dysbiosis and intestinal mucositis. Female BALB/c mice were divided into three groups: a 5-FU group, a 5-FU+Pro group receiving free probiotics, and a 5-FU+RS-Pro group receiving RS-encapsulated probiotics. After 28 days of treatment, analyses were conducted on fecal microbiota, intestinal histology, peripheral blood cell counts, and body and organ weights. It was revealed by 16S rRNA MiSeq sequencing that 5-FU treatment disrupted gut microbiota composition, reduced microbial diversity, and caused dysbiosis. RS-Pro treatment restored microbial diversity and increased the population of beneficial bacteria, such as Muribaculaceae, which play roles in carbohydrate and polyphenol metabolism. Furthermore, 5-FU administration induced moderate intestinal mucositis, characterized by reduced cellularity and shortened villi. However, RS-Pro treatment attenuated 5-FU-induced intestinal damage, preserving villus length. Mild leukopenia observed in the 5-FU-treated mice was partially alleviated in 5-FU+Pro and 5-FU+RS-Pro groups. These findings suggest that RS-Pro may serve as an adjunct to chemotherapy, potentially reducing adverse effects and improving therapeutic outcomes in future clinical applications.
Apatite Formation on α-Tricalcium Phosphate Modified with Bioresponsive Ceramics in Simulated Body Fluid Containing Alkaline Phosphatase
Authors: Yokoi Taishi , Tomita Shinji , Nakamura Jin , Sugawara-Narutaki Ayae , Matsukawa Yuko , Kawashita Masakazu , Ohtsuki Chikara
Published: August 2024

Bioresponsive ceramics, a new concept in ceramic biomaterials, respond to biological molecules or environments, as exemplified by salts composed of calcium ions and phosphate esters (SCPEs). SCPEs have been shown to form apatite in simulated body fluid (SBF) containing alkaline phosphatase (ALP). Thus, surface modification with SCPEs is expected to improve the apatite-forming ability of a material. In this study, we modified the surface of α-tricalcium phosphate (α-TCP) using methyl, butyl, or dodecyl phosphate to form SCPEs and investigated their apatite formation in SBF and SBF containing ALP. Although apatite did not form on the surface of the unmodified α-TCP in SBF, apatite formation was observed following surface modification with methyl or butyl phosphate. When ALP was present in SBF, apatite formation was especially remarkable on α-TCP modified with butyl phosphate. These SCPEs accelerated apatite formation by releasing calcium ions through dissolution and supplying inorganic phosphate ions, with the latter process only occurring in SBF containing ALP. Notably, no apatite formation occurred on α-TCP modified with dodecyl phosphate, likely because of the low solubility of the resulting calcium dodecyl phosphate/calcium phosphate composites. This new method of using SCPEs is anticipated to contribute to the development of novel ceramic biomaterials.
Genetically Predicted Association of 91 Circulating Inflammatory Proteins with Multiple Sclerosis: A Mendelian Randomization Study
Authors: Li Xin’ai , Ding Zhiguo , Qi Shuo , Wang Peng , Wang Junhui , Zhou Jingwei
Published: August 2024

Previous studies have validated a close association between inflammatory factors and multiple sclerosis (MS), but their causal relationship is not fully profiled yet. This study used Mendelian randomization (MR) to investigate the causal effect of circulating inflammatory proteins on MS. Data from a large-scale genome-wide association study (GWAS) were analyzed using a two-sample MR method to explore the relationship between 91 circulating inflammatory proteins and MS. The inverse-variance-weighted (IVW) analysis was employed as the main method for evaluating exposures and outcomes. Furthermore, series of the methods of MR Egger, weighted median, simple mode, and weighted mode were used to fortify the final results. The results of the IVW method were corrected with Bonferroni (bon) and false discovery rate (fdr) for validating the robustness of results and ensuring the absence of heterogeneity and horizontal pleiotropy. The sensitivity analysis was also performed. The results of the forward MR analysis showed that higher levels of CCL25 were found to be associated with an increased risk of MS according to IVW results, OR: 1.085, 95% CI (1.011, 1.165), p = 2.42 × 10−2, adjusted p_adj_bon = 1, p_adj_fdr = 0.307. Similarly, higher levels of CXCL10 were found to be associated with an increased risk of MS, OR: 1.231, 95% CI (1.057, 1.433), p = 7.49 × 10−3, adjusted p_adj_bon = 0.682, p_adj_fdr = 0.227. In contrast, elevated levels of neurturin (NRTN) were associated with a decreased risk of MS, OR: 0.815, 95% CI (0.689, 0.964), p = 1.68 × 10−2, adjusted p_adj_bon = 1, p_adj_fdr = 0.307. Reverse MR analysis showed no causal relationship between MS and the identified circulating inflammatory cytokines. The effects of heterogeneity and level pleiotropy were further excluded by sensitivity analysis. This study provides new insights into the relationship between circulating inflammatory proteins and MS and brings up a new possibility of using these cytokines as potential biomarkers and therapeutic targets. The data in this study show that there are only weak associations between inflammatory molecules and MS risk, which did not survive bon and fdr correction, and the obtained p-values are quite low. Therefore, further studies on larger samples are needed.
The Effectiveness of Overground Robot Exoskeleton Gait Training on Gait Outcomes, Balance, and Motor Function in Patients with Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Lee Myoung-Ho , Tian Ming-Yu , Kim Myoung-Kwon
Published: August 2024

Objective: This study aimed to investigate the effects of overground robot exoskeleton gait training on gait outcomes, balance, and motor function in patients with stroke. Methods: Following the PRISMA guidelines, literature searches were performed in the PubMed, EMBASE, Cochrane Central Register of Controlled Trials, SCOPUS, Ovid-LWW, and RISS databases. A total of 504 articles were identified, of which 19 were included for analysis after application of the inclusion and exclusion criteria. The included literature was qualitatively evaluated using the PEDro scale, while the Egger’s regression, funnel plot, and trim-and-fill methods were applied to assess and adjust for publication bias. Results: The averaged PEDro score was 6.21 points, indicating a high level of methodological quality. In the analysis based on dependent variables, higher effect sizes were observed in the following ascending order: gait speed (g = 0.26), motor function (g = 0.21), gait ability (g = 0.18), Timed Up and Go Test (g = −0.15), gait endurance (g = 0.11), and Berg Balance Scale (g = 0.05). Subgroup analyses further revealed significant differences in Asian populations (g = 0.26), sessions lasting longer than 30 min (g = 0.37), training frequency of three times per week or less (g = 0.38), and training duration of four weeks or less (g = 0.25). Overall, the results of this study indicate that overground robot exoskeleton gait training is effective at improving gait speed in patients with stroke, particularly when the sessions exceed 30 min, are conducted three times or less per week, and last for four weeks or less. Conclusion: our results suggest that training is an effective intervention for patients with stroke, provided that appropriate goal-setting and intensity and overground robot exoskeleton gait are applied.
Characteristics of Intracranial Kinetic Loads When Sports-Related Concussion Occurs in Men’s Rhythmic Gymnastics
Authors: Otsubo Shunya , Shigemori Yutaka , Endo Sena , Fukushima Hiroshi , Tachihara Muneyuki , Goto Kyosuke , Tsurusaki Rino , Otsuka Nana , Masuda Kentaro , Zhang Yuelin
Published: August 2024

This study aimed to clarify the differences between the previously reported mechanisms of sports-related concussion (SRC) injuries without a loss of consciousness in contact and collision sports and the mechanisms of SRC injuries in our cases. Based on two videos of SRC injuries occurring during a men’s rhythmic gymnastics competition (three people were injured), the risk of SRC occurrence was estimated from various parameters using a multibody analysis and eight brain injury evaluation criteria. In the present study, the three SRC impacts that occurred in men’s rhythmic gymnastics showed significant characteristics in duration compared to previously reported cases in the contact sports. This suggests that the occurrence of SRC may have been caused by a different type of impact from that which causes SRC in contact sports (e.g., tackling). In addition, calculation of the strain indicating the rate of brain deformation suggested a risk of nerve swelling in all cases involving type 2 axonal injuries. Therefore, when reexamining sports-related head injuries, it is important to recognize the characteristics and mechanisms of SRC that occur in each different sport, as well as the symptoms and course of SRC after injury.
From Infancy to Childhood: A Comprehensive Review of Event- and Task-Related Brain Oscillations
Authors: Ünsal Esra , Duygun Rümeysa , Yemeniciler İrem , Bingöl Elifnur , Ceran Ömer , Güntekin Bahar
Published: August 2024

Brain development from infancy through childhood involves complex structural and functional changes influenced by both internal and external factors. This review provides a comprehensive analysis of event and task-related brain oscillations, focusing on developmental changes across different frequency bands, including delta, theta, alpha, beta, and gamma. Electroencephalography (EEG) studies highlight that these oscillations serve as functional building blocks for sensory and cognitive processes, with significant variations observed across different developmental stages. Delta oscillations, primarily associated with deep sleep and early cognitive demands, gradually diminish as children age. Theta rhythms, crucial for attention and memory, display a distinct pattern in early childhood, evolving with cognitive maturation. Alpha oscillations, reflecting thalamocortical interactions and cognitive performance, increase in complexity with age. Beta rhythms, linked to active thinking and problem-solving, show developmental differences in motor and cognitive tasks. Gamma oscillations, associated with higher cognitive functions, exhibit notable changes in response to sensory stimuli and cognitive tasks. This review underscores the importance of understanding oscillatory dynamics to elucidate brain development and its implications for sensory and cognitive processing in childhood. The findings provide a foundation for future research on developmental neuroscience and potential clinical applications.
Evaluating the Design Principles of Traditional Safranbolu Houses
Authors: Şahin Rüveyda , Dinçer Ahmet Emre
Published: August 2024

Safranbolu, located in the Western Black Sea region of northern Turkey, consists of three historical settlements distinguished by monumental buildings and especially traditional houses. For this reason, the city was declared a ‘World Heritage Site’ by UNESCO in 1994. Traditional Safranbolu houses are examples of Turkish houses built with mixed techniques. In research on Turkish residences and traditional Safranbolu houses, the focus has been on the origin of dwelling construction culture, the spatial reading of the parts of the house, the sociocultural life of the owners, and the surveying of traditional construction techniques. In this study, the design principles affecting the spatial arrangement of Safranbolu houses were evaluated from a holistic perspective. Dwellings selected from Safranbolu sites were analyzed at the urban scale according to the environmental design data of the residential area. It can be seen that houses were designed in a certain order according to these factors. In the building scale analyses, the diversity in the domestic space configuration was surveyed by the drawings of immediate environments at the plans and sections of the houses. The study contributes by explaining the relationship between parcel characteristics and house design.
The Effects of Dolomite Powder Content and Type on the Yield Stress Relationship between Self-Compacting Mortar and Paste
Authors: Zhang Jingbin , Chen Hongyu , Jia Yan , Zhuoma Pingcuo , Lv Miao
Published: August 2024

Self-compacting concrete (SCC), known for its excellent fluidity and self-compacting ability, is widely used in civil engineering. To enhance the comprehensive performance of SCC, dolomite powder (DP) is integrated as a substitute for cement. This study aims to analyze the impact of DP on the yield stress relationship between self-compacting mortar (SCM) and self-compacting paste (SCP) from a multi-scale perspective. A new predictive model for the yield stress relationship between SCM and SCP incorporating DP is established by improving the n value in the existing ϕe model, which characterizes the sensitivity of the mortar yield stress relative to changes in the paste yield stress. By conducting mini-slump flow tests on nine sets of cement–DP mixtures, it is found that DP impacts the yield stress relationship between SCM and SCP mainly through changes in the inter-particle filling effect, and the n value in the predictive model is roughly between 2.4 and 3.6. When the DP content is kept constant and the particle size is changed, the n value shows a strong positive linear relationship with the packing density of the paste (ϕe,p). The relationship between n and ϕe,p is derived using the linear fitting method, which improves the model’s predictive accuracy by 95.2%.
Protective Effects of Small Molecular Inhibitors on Steel Corrosion: The Generation of a Multi-Electric Layer on Passivation Films
Authors: Wu Shenrong , Liu Chengbo , Xu Hongjian , Guo Feng , Chen Feixiang , Li Mengmeng , Wang Pan
Published: August 2024

The durability of reinforced concrete structures is significantly influenced by the effectiveness of small molecular inhibitors in preventing the corrosion of steel reinforcements. In a concrete environment, the passive film on steel bars serves as a critical protective component. In this study, a molecular dynamics (MD) simulation is used to study the inhibition mechanism of chloride ions by common corrosion inhibitors (2-Amino-2-thiazoline) in concrete in an excess chloride solution. The results reveal that inhibitors adsorb onto the steel surface primarily through van der Waals forces, with more than 90% of the adsorption occurring vertically. Despite this strong adsorption, inhibitors alone do not form a protective film. In the presence of chloride ions, which frequently penetrate concrete, the coverage rate of inhibitors on the steel surface decreases from 74% to 64%. Nevertheless, inhibitor molecules still provide substantial protection in chloride-rich concrete environments. Further analysis indicates that inhibitor molecules inhibit chloride ions in two ways. Corrosion inhibitor molecules actively desorb from the steel surface to capture chloride ions and prevent them from approaching. Additionally, inhibitors form a multi-electron layer on the steel surface to enhance passive film protection and hinder chloride ion diffusion through Coulombic interactions.
Spatial Adaptive Improvement Detection Network for Corroded Bolt Detection in Tunnels
Authors: Guo Zhiwei , Cheng Xianfeng , Xie Quanmin , Zhou Hui
Published: August 2024

The detection of corroded bolts is crucial for tunnel safety. However, the specific directionality and complex texture of corroded bolt defects make current YOLO series models unable to identify them accurately. This study proposes a spatial adaptive improved detection network (SAIDN), which integrates a spatial adaptive improvement module (SAIM) that adaptively emphasizes important features and reduces interference, enhancing detection accuracy. The SAIM performs a detailed analysis and transformation of features in the spatial and channel dimensions, enhancing the model’s ability to recognize critical defect information. The use of depthwise separable convolutions and adaptive feature reweighting strategies improves detail processing capabilities and computational efficiency. Experimental results show that SAIDN significantly outperforms existing models in detection accuracy, achieving 94.4% accuracy and 98.5% recall, surpassing advanced models such as YOLOv9 and Cascade RCNN. These findings highlight the potential of SAIDN in enhancing subway tunnels’ safety and maintenance efficiency.
From ‘Objects’ to ‘Sustainable Development’: The Evolution of Architectural Heritage Conservation in Theory and Practice
Authors: Fayez Homaira
Published: August 2024

Over the last century, architectural heritage conservation has evolved and transformed immensely. This study focuses on the origin of contemporary conservation theory from the 19th century and the Authorized Heritage Discourse: the doctrinal texts issued by ICOMOS, UNESCO, and ICCROM. Conservation philosophies from 5 theorists and 23 charters and documents are analyzed from a qualitative perspective. It is structured on three interwoven and complementary theses: first, a study of the 19th and 20th centuries is presented as the backbone of conservation theories; second, a detailed analysis of the Venice Charter is given; and third, an investigation into the authorized conservation policies after the establishment of the Venice Charter. The aim is to understand the evolution of architectural heritage conservation in the dynamics of the time and space of the last century, in theory and practice. The results demonstrate that architectural conservation began with a strong privilege of objectivity in practice to create a real, tangible, and static object that was concerned only with individual monuments or sites vulnerable to the trace of time, stylistic restoration, and armed conflicts. However, recent socio-economic and environmental demands and challenges have transformed this understanding to make conservation a subjective, dynamic, value-linked, and contextual-based approach. Such shifts result from realizing the additional potential of heritage buildings that can enhance viability and livability in communities; as existing resources with high material residual values, embodied material, and energy, their continuous renovation and rehabilitation contribute to urban environment resilience and decarbonization; and as a source of past experience rooted in all aspects of societies that can be used to educate and raise awareness about the crisis of climate change. Accordingly, four chapters in architectural heritage conservation have been identified: 1. It originated to preserve the authenticity and integrity of the material past by experts; 2. then, it moved to the protection of associated values, still with a strong tendency toward conservation of the authentic state of heritage buildings by experts and with local consultation; 3. the significant socio-economic role of heritage for the community made its conservation a democratic exercise by local people with the help of experts and governments; 4. realizing the environmental benefit of reusing existing resources, nowadays, conservation intermeshes with the sustainable development of communities through multi-stakeholder engagement in all decision-making processes.
The Impact of Site Contexts in Increasing the Diversity of Architectural Concepts: Using an Interactive Architectural Approach
Authors: Baper Salahaddin Yasin , Ismael Zhiman Khairi
Published: August 2024

Recently, new alternatives have been applied to enhance the architectural design process through comprehensive interaction with all variables. This approach suggests a dynamic scheme to collect all factors comprehensively. This research introduces approaches to better cognition of architectural concepts based on the site context parameter. It investigates the role of site context in generating architectural ideas by formulating a model of analysis to find similarities and differences in senior architects’ strategies. This approach aims to adapt context to explore aspects that may create diversity in architectural products. The reality is that creating original architectural concepts has received progressively less attention in the professional practice of architecture in recent decades. The research applied a mixed methodology, checklist factors and graphical analysis. It used a two-level method with several steps to evaluate the twelve international cases related to deconstructive architects (Eisenman, Koolhaas, and Hadid). This study concludes that creating a site context that supports the surrounding context can enrich the design concept and create unexpected results.
Towards Climate, Bioclimatism, and Building Performance—A Characterization of the Brazilian Territory from 2008 to 2022
Authors: da Silva Mario A. , Pernigotto Giovanni , Gasparella Andrea , Carlo Joyce C.
Published: August 2024

Representative weather data are fundamental to characterizing a place and determining ideal design approaches. This is particularly important for large countries like Brazil, whose extension and geographical position contribute to defining diverse climatic conditions along the territory. In this context, this study intends to characterize the Brazilian territory based on a 15-year weather record (2008–2022), providing a climatic assessment based on a climatic and bioclimatic profile for the whole country. The climate analysis was focused on temperature, humidity, precipitation, and solar radiation, followed by a bioclimatic analysis guided by the Givoni chart and the natural ventilation potential assessment. In both situations, the results were analyzed using three resolutions: country-level, administrative division, and bioclimatic zones. This study also identified representative locations for the Brazilian bioclimatic zones for a building-centered analysis based on the thermal and energy performance of a single-family house with different envelope configurations. The results proved that most Brazilian territories increased above 0.4 °C in the dry bulb temperature and reduced relative humidity. The precipitation had the highest reduction, reaching more than 50% for some locations. The warmer and drier conditions impacted also the Köppen–Geiger classification, with an increase in the number of Semi-Arid and Arid locations. The bioclimatic study showed that ventilation is the primary strategy for the Brazilian territory, as confirmed by the natural ventilation potential results, followed by passive heating strategies during the year’s coldest months. Finally, building performance simulation underlined that, in colder climates, indoor thermal comfort conditions and air-conditioning demands are less affected by solar absorptance for constructions with low U-values, while in warmer climates, low solar absorptance with intermediary U-values is recommended.
Cu/MgO as an Efficient New Catalyst for the Non-Oxidative Dehydrogenation of Ethanol into Acetaldehyde
Authors: Tian Chao , Yue Yinghong , Miao Changxi , Hua Weiming , Gao Zi
Published: August 2024

The non-oxidative dehydrogenation of ethanol into acetaldehyde is one of the efficient solutions for biomass upgrading. In this work, a series of copper catalysts supported on MgO with different Cu loadings ranging from 2.5% to 20% were prepared by an impregnation method. The as-synthesized Cu/MgO catalysts were characterized by N2 adsorption, XRD, TEM, CO2-TPD, XPS and TPR. These catalysts were found to be effective for ethanol dehydrogenation into acetaldehyde. As the Cu loading was increased, the ethanol conversion first increased and then leveled off. At a WHSV of 1.5 h−1 and 250 °C, the 20%Cu/MgO catalyst gave an initial conversion of 81.5%, with 97.7% selectivity toward acetaldehyde. Compared to 20%Cu/SiO2, the 20%Cu/MgO catalyst displayed an equivalent initial acetaldehyde yield, higher acetaldehyde selectivity and longer stability.