ACTIV SARS-CoV-2 registry (Analysis of Chronic Non-infectious Diseases Dynamics After COVID-19 Infection in Adult Patients). Assessment of impact of combined original comorbid diseases in patients with COVID-19 on the prognosis
Authors: Arutyunov Gregory P. , Tarlovskaya Ekaterina I. , Arutyunov Alexander G. , Belenkov Yuri N. , Konradi Alexandra O. , Lopatin Yury M. , Rebrov Andrey  P. , Tereshchenko Sergey N. , Chesnikova Anna I. , Hayrapetyan Hamlet G. , Babin Aleksandr P. , Bakulin Igor G. , Bakulina Natalia V. , Balykova Larisa A. , Blagonravova Anna S. , Boldina Marina V. , Vaisberg Alexandra R. , Galyavich Albert S. , Gomonova Veronika V. , Grigorieva Natalia Yu. , Gubareva Irina V. , Demko Irina V. , Evzerikhina Angelika V. , Zharkov Aleksandr V. , Kamilova Umida K. , Kim Zulfia F. , Kuznetsova Tatiana Yu. , Lareva Natalia V. , Makarova Ekaterina V. , Malchikova Svetlana V. , Nedogoda Sergey V. , Petrova Marina M. , Pochinka Ilya G. , Protasov Konstantin V. , Protsenko Denis N. , Ruzanau Dmitry Yu. , Sayganov Sergey A. , Sarybaev Akpay S. , Selezneva Natalia M. , Sugraliev Akhmetzhan B. , Fomin Igor V. , Khlynova Olga V. , Chizhova Olga Yu. , Shaposhnik Igor I. , Sh'ukarev Dmitry A. , Abdrahmanova Айгуль K. , Avetisian Susanna A. , Avoyan Hovhannes G. , Azarian Karine K. , Aimakhanova Galiya T. , Ayipova Dinara A. , Akunov Almazbek Ch. , Alieva Marianna K. , Aparkina Aliona V. , Aruslanova Olga R. , Ashina Ekaterina Yu. , Badina Olga Yu. , Barisheva Olga Yu. , Batchayeva Alina S. , Bitieva Anna M. , Bikhteyev Ismail U. , Borodulina Nataliya A. , Bragin Maksim V. , Budu Angela M. , Bykova Galina M. , Vagapova Kristina R. , Varlamova Darina D. , Vezikova Natalia N. , Verbitskaya Elena A. , Vilkova Olga E. , Vinnikova Elena A. , Vustina Vera V. , Galova Elena A. , Genkel Vadim V. , Gorshenina Elena I. , Gostishev Roman V. , Grigorieva Elena V. , Gubareva Ekaterina Yu. , Dabylova Gaukhar M. , Demchenko Anastasiya I. , Dolgikh Oleg Yu. , Duyshobayev Melis Y. , Evdokimov Dmitrii S. , Egorova Ksenia E. , Ermilova Anastasiia N. , Zheldybayeva Aliya E. , Zarechnova Nataliya V. , Zimina Yuliia D. , Ivanova Svetlana Yu. , Ivanchenko Elena Yu. , Ilina Mariya V. , Kazakovtseva Maria V. , Kazymova Elena V. , Kalinina Yuliya S. , Kamardina Nadezhda A. , Karachenova Anastasiya M. , Karetnikov Igor A. , Karoli Nina A. , Karsiev Magomed Kh. , Кaskaeva Daria S. , Kasymova Karina F. , Kerimbekova Zhainagul B. , Kerimova Ailar Sh. , Kim Eugeni S. , Kiseleva Nina V. , Klimenko Darya A. , Klimova Anastasiia V. , Kovalishena Olga V. , Kolmakova Elena V. , Kolchinskaya Tatyana P. , Kolyadich Maria I. , Kondriakova Olga V. , Konoval Marina P. , Konstantinov Dmitryi Yu. , Konstantinova Elena A. , Kordukova Vera A. , Koroleva Ekaterina V. , Kraposhina Angelina Yu. , Kriukova Tamara V. , Kuznetsova Alla S. , Kuzmina Tatyana Yu. , Kuzmichev Kirill V. , Kulchoroevna Cholpon K. , Kuprina Tatiana V. , Kouranova Irina M. , Kurenkova Liliya V. , Kurchugina Natalia Yu. , Kushubakova Nadira A. , Levankova Valeriia I. , Lyubavina Natalia A. , Magdeyeva Nadezhda A. , Mazalov Konstantin V. , Majseenko Viktoryia I. , Makarova Aleksandra S. , Maripov Abdirashit M. , Marusina Anastasiia A. , Melnikov Evgenii S. , Moiseenko Nikita B. , Muradova Fazliniso N. , Muradyan Rimma G. , Musaelian Shahane N. , Myshak Anton O. , Nekaeva Ekaterina S. , Nikitina Nataliia M. , Ogurlieva Bela B. , Odegova Alla A. , Omarova Yuliia V. , Omurzakova Nazgul A. , Ospanova Shynar O. , Pahomova Ekaterina V. , Petrov Liviu D. , Plastinina Svetlana S. , Pogrebetskaya Vera A. , Polyakov Dmitry S. , Ponomarenko Ekaterina V. , Popova Larisa L. , Prokofeva Natalya A. , Pudova Inna A. , Rakov Nikita A. , Rahimov Abdurakhmon N. , Rozanova Nadezhda A. , Serikbolkyzy Saltanat , Simonov Andrei A , Skachkova Valeriya V. , Soloveva Daria V. , Soloveva Irina A. , Subbotin Alexander K. , Sukhomlinova Irina M. , Sushilova Anastasiia G. , Tagayeva Dilnoza R. , Titojkina Yuliia V. , Tikhonova Elena P. , Tokmin Danil S. , Tolmacheva Anastasiia A. , Torgunakova Mariya S. , Trenogina Ksenia V. , Trostianetckaia Natalia A. , Trofimov Dmitriy A. , Tulichev Alexander A. , Tursunova Assiya T. , Ulanova Nina D. , Fatenkov Oleg V. , Fedorishina Olga V. , Fil Tatiana S. , Fomina Irina Yu. , Fominova Irina S. , Frolova Irina A. , Tsvinger Svetlana M. , Tsoma Vera V. , Cholponbaeva Meerim B. , Chudinovskikh Tatiana I. , Shevchenko Olga A. , Sheshina Tatyana V. , Shishkina Ekaterina A. , Shishkov Konstantin Yu. , Sherbakov Stanislav Yu. , Yausheva Ekaterina A. 
Published: March 2022

Aim. Study the impact of various combinations of comorbid original diseases in patients infected with COVID-19 later on the disease progression and outcomes of the new coronavirus infection.
Materials and methods. The ACTIV registry was created on the Eurasian Association of Therapists initiative. 5,808 patients have been included in the registry: men and women with COVID-19 treated at hospital or at home. ClinicalTrials.gov ID NCT04492384.
Results. Most patients with COVID-19 have original comorbid diseases (oCDs). Polymorbidity assessed by way of simple counting of oCDs is an independent factor in negative outcomes of COVID-19. Search for most frequent combinations of 2, 3 and 4 oCDs has revealed absolute domination of cardiovascular diseases (all possible variants). The most unfavorable combination of 2 oCDs includes atrial hypertension (AH) and chronic heart failure (CHF). The most unfavorable combination of 3 oCDs includes AH, coronary heart disease (CHD) and CHF; the worst combination of 4 oCDs includes AH, CHD, CHF and diabetes mellitus. Such combinations increased the risk of lethal outcomes 3.963, 4.082 and 4.215 times respectively.
Conclusion. Polymorbidity determined by way of simple counting of diseases may be estimated as a factor in the lethal outcome risk in the acute phase of COVID-19 in real practice. Most frequent combinations of 2, 3 and 4 diseases in patients with COVID-19 primarily include cardiovascular diseases (AH, CHD and CHF), diabetes mellitus and obesity. Combinations of such diseases increase the COVID-19 lethal outcome risk.