bluuebunny/crossref_metadata_2025 huggingface dataset:
Safety evaluation of excessive intake of Hesperetin-7-Glucoside-β-Cyclodextrin Inclusion Complex in Healthy Japanese Subjects
Authors: Moriwaki Masamitsu , Abe Aya , Kapoor Mahendra P , Yamaguchi Akiko , Okamoto Saki , Ozeki Makoto
Published: March 2024

Background: Hesperidin, a flavonoid glycoside, is widely found in the peels and rinds of citrus fruits, offering various physiological benefits. However, its effectiveness is hindered by challenges related to insolubility and low bioavailability. To overcome these obstacles, we developed the Hesperetin-7-glucoside -β-cyclodextrin inclusion complex (HCD). This complex demonstrates superior solubility and bioavailability compared to hesperidin. In a previous study where participants consumed 300 mg/day of HCD for 12 weeks, there was a notable improvement in endothelial dysfunction. Importantly, no significant adverse clinical events were reported during this period.
Objective: To evaluate the safety of the excessive intake of HCD in Healthy Japanese subjects.
Methods: Fourteen healthy male and female volunteers (with a mean age of 39.1±9.1) participated in this excessive HCD intake clinical trial. Subjects took 1500 mg/day HCD, which was five times the dosage of 300 mg/day HCD, for 4 consecutive weeks. Physical examination, blood tests, and uric tests were performed during this period.
Results: Results demonstrated no significant differences at 2, and 4 weeks compared to the baseline at 0 weeks with 1500 mg HCD (equivalent to 195 mg HPTG) supplementation in healthy subjects.
Conclusions: It has been demonstrated that there are no safety concerns when consuming 1500 mg of HCD daily, continuously for 4 weeks.
Keywords: Safety, Bioavailability, Clinical trials, Hesperidin, Food, Foods with Function Claims, Overdose supplementation, Cyclodextrin
Trial registration: UMIN-CTR (Trial ID: UMIN000051960)
Foundation: Taiyo Kagaku Co. Ltd.
Why We Stop Synthesizing Essential Amino Acids: The Extracellular Protein Hypothesis
Authors: Esumi Genshiro
Published: March 2024

Humans cannot synthesize nine of the twenty amino acids that constitute proteins, known as essential amino acids. It has been traditionally considered that this inability arose because humans could obtain these amino acids in sufficient quantities through their diet. However, recent advances in life sciences have shown that all eukaryotic organisms with the ability to ingest external protein resources have uniformly lost the ability to synthesize almost identical amino acids, including those belonging to branches of the evolutionary tree entirely different from humans, such as _Dictyostelium_ and _Tetrahymena_. Yet, the reasons behind their essentiality and the commonality of these essential amino acids remain elusive and unexplained. In this paper, I propose a novel and simple explanation that ORGANISMS CAN MAINTAIN THEIR AMINO ACID BALANCE BY SOLELY SYNTHESIZING AMINO ACIDS THAT ARE MORE ABUNDANT IN EXTRACELLULAR PROTEINS COMPARED TO INTRACELLULAR PROTEINS. This explanation is based on two previously unrecognized assumptions. The first assumption is that intracellular proteins act as amino acid buffers for subsequent protein synthesis, facilitated by the continuous recycling of their amino acids during the degradation and synthesis cycle. The second assumption is that there are consistent differences in amino acid composition between extracellular and intracellular proteins, economically driven by the lower synthesis costs for extracellular structures. Despite the limited data available for examining these assumptions, the evidence lends support to their validity. Therefore, this "Extracellular Protein Hypothesis" provides a novel and convincing explanation to the nearly century-old mystery: the origin of essential amino acids.
Measurement Mechanics
Authors: Krechmer Ken
Published: March 2024

"Measurement Mechanics" (MM) applies statistical mechanics to reframe representational measurement theory (probabilistic) and metrology (deterministic). This is shown to unify the different measurement theories and correlate the different formulations of measurement result deviation (i.e., uncertainty, standard deviation, variance, precision and accuracy) across the sciences.

Following Euler (1765), MM identifies that repetitive measurements of an unchanged observable produce measurement result distributions relative to a reference or standard. Such repetitive measurement results (without noise or distortion) appear as a Gaussian distribution of probabilistic measurement result quantities (numerical values and units), not a single numerical value with an error distribution as current representational measurement theory indicates. MM treats these distributions not as errors, but as all the statistically possible sums of a measurement apparatus's interval values relative to a reference or standard.

Fig. 1 identifies the frame of reference; Fig. 2 diagrams representational measurement theory; Fig. 3 diagrams how metrology relates to representational theory; and Fig. 4 proposes measurement mechanics.

The result of the paper's development (eq. (8) on page 12) identifies that the proposed statistical measurement function converges to the commonly applied metrology measurement function when the numerical value is large. The ramifications to measurement theories and experiments are summarized in the three paragraphs below it.
The Contradiction of Populism and Judicial Independence (Unraveling Alexander Bickel’s Counter-Majoritarian Dilemma in the Context of the Indonesian Constitutional Court)
Authors: Muhtar Mohamad Hidayat
Published: March 2024

The purpose of this writing is to analyze the contradiction between populism and the Counter-Majoritarian Dilemma, as well as their impact on the independence of the Indonesian Constitutional Court (ICC) and how the ICC maintains its independence while strengthening its legitimacy amidst populist rulings. The study utilizes normative legal writing with a philosophical and analytical approach, employing a descriptive-analytical method. The findings reveal a contradiction between populism and the independence of the ICC within the context of Indonesian politics. Populism prioritizes the interests of the people and opposes political elites, while the ICC's independence necessitates unbiased execution of its duties, unaffected by political interests. Despite the ICC's crucial role in upholding independence and justice within Indonesia's legal system, its autonomy is often threatened by political influence and populism during decision-making. Alexander Bickel's Counter-Majoritarian Dilemma theory provides insight into this challenge, emphasizing the importance of basing judicial decisions on objective constitutional principles. Populism can impact the ICC's independence as it must consider the people's interests, yet continued erosion of independence due to political influence jeopardizes both the ICC's autonomy and the fairness of the legal system. Hence, it is vital for the ICC to preserve its independence as a constitutional guardian, considering the people's interests, safeguarding constitutional rights, and carrying out its duties impartially, free from the influence of populism or political interests. By doing so, the ICC can establish itself as an independent and equitable institution, strengthening public trust in the legal system and democracy in Indonesia.
The History of Education in Antiquity and Its Teaching: Epistemological Problems
Authors: Bontempi Junior Bruno
Published: March 2024

This essay is a critical exploration of the condition of teaching of History of Education in Antiquity, a topic of manuals and disciplines in teacher training courses. In the approach to the content, it becomes evident both the ethnocentric character of the histories of philosophy and culture born in the nineteenth century and the utilitarian and moralistic purpose that justified their condition in the curricula of teachers' schools. This article also addresses the relative abandonment and lag of research on the subject when new theoretical-methodological perspectives in this field emerge. Finally, it is pointed the challenges to the persistence of this traditional form in the face of the epistemological and identity insurgencies of contemporaneity.
Uji aktivitas ekstrak etanol (Zingiber officinale Roscoe) sebagai antiinflamasi
Authors: Putra Ari Permana , Aisyah Rizka , Naintina Luh Yuni
Published: March 2024

Jahe (Zingiber officinale Rosc.) merupakan obat tradisonal yang digunakan untuk mengatasi inflamasi, jahe memiliki kandungan gingerol yang dapat menghambat aktivitas siklooksigenase dan lipoksigenase dalam asam arakhidonat sehingga dapat menurunkan prostaglandin dan leukotrin. Tujuan dalam penelitian ini yaitu untuk mengetahui uji aktivitas ekstrak etanol jahe (Zingiber officinale Rosc.) dengan menggunakan pembanding Na Diklofenak. Metode yang digunakan yaitu penelitian eksperimental rancangan acak lengkap dengan pola satu arah. Metode yang digunakan adalah metode Langford yang telah dimodifikasi dengan mengukur ketebalan edema pada kaki mencit menggunakan jangka sorong digital. Hasil dari penelitian ini Na Diklofenak memiliki persentase hambat lebih baik daripada ekstrak etanol jahe (Zingiber officinale Rosc.) Dosis I, II, dan III. Hasil ANOVA menunjukan memiliki perbedaan yang bermakna dengan P<0,0001.
Kata Kunci: Jahe; antiinflamasi; langford
FERTILIZATION, CLEVEAGE AND IMPLANTATION
Authors: Hayati Lusia
Published: March 2024

Most of the livestock in Indonesia are still conventional or traditional farms, where the quality of the seeds, the use of technology and the skills of farmers are still relatively low, thus affecting the productivity and genetic quality of livestock. Therefore it is necessary to have knowledge about livestock reproduction that discusses fertilization, cleveage and implantation. Fertilization or fertilization (singami) is the fusion of two gametes which can be a nucleus or nucleus cells to form a single cell (zygote) or fusion of the nucleus. the process starts with the preparation of ovum cells and spermatozoa; penetration; core incorporation; and early zygote cleavage. Fertilization phase is the meeting between sperm cells and ovum cells and will produce zygote. Zygote will perform cell division (cleavage). The zygote then undergoes growth and development through stages, namely division, gastrulation, and organogenesis. Implantation or also known as oxidation is the process of implanting the embryo, which is the result of conception, into the uterine wall (endometrium) to further develop.
UHI based Healthcare Management System through Digital Transformation
Authors: Patil Sumit , Khairnar Rohit , Rane Keval , Nimje Pavan , Zala Dhruvi
Published: March 2024

The Unified Health Interface (UHI) represents a pivotal initiative within the Indian healthcare landscape, offering an open and interoperable IT ecosystem tailored for modern and innovative health service delivery. In response to the challenges posed by the COVID-19 pandemic, UHI emerges as a strategic solution aimed at ensuring enhanced accessibility and quality of healthcare services. Through its seamless interface, UHI facilitates various functionalities including online search, lab test bookings, virtual medical consultations via video, voice, or chat, digital transfer of health records, and secure digital payments. This paper explores the transformative potential of UHI in addressing the evolving needs of healthcare delivery in India. By fostering ease of application and improving access to quality healthcare services, UHI stands as a cornerstone in the nation's healthcare infrastructure. The emergence of enterprise- and national-level healthcare systems underscores the growing demand for comprehensive and cost-effective public healthcare solutions. Leveraging classic telecommunications and internet services such as presence, voice, video, and messaging, along with service composition solutions and enterprise networks, UHI lays the groundwork for unified health applications. This research delves into the implications of UHI in driving healthcare accessibility, affordability, and efficiency, while also examining its role in shaping the future trajectory of healthcare delivery in India. By elucidating the integration of UHI within existing healthcare frameworks, this paper provides valuable insights into the transformative potential of digital technologies in revolutionizing public health services.
Educação, educador e a educação comparada: numa abordagem de futuro
Authors: Santos Genivaldo dos
Published: March 2024

O presente trabalho tem como intenção abordar sobre a educação, educador e a educação comparada: numa abordagem de futuro, possibilitando uma maior discursão sobre a educação comparada, uma vez que a função da educação e do educador deve ser compreendida não só como meios e procedimentos que facilitam a construção do conhecimento, mas também como realidades que preparam sujeitos que possam desenvolver habilidades e competências que assegurem a inserção dos mesmos no universo laboral global, tornando-os capazes de, na grande corrida competitiva, alcançar seus ideais e, profissionalmente, assumirem o seu lugar na sociedade. Neste sentido, tanto o ato de educar como as ações do educador têm suscitado grandes interesses de análises por serem também responsáveis na condução dos educandos, fazendo com que os mesmos alcancem uma visão não somente da realidade em que estão inseridos, mas sim um olhar amplo e global das problemáticas e oportunidades que cada vez mais vão surgindo no cenário social nacional e internacional. Nesta pesquisa objetiva-se despertar uma maior reflexão a respeito do conceito da educação comparada e a função do educador, como realidades facilitadoras ou mediadoras na construção do saber, no processo de ensino e aprendizagem, para uma educação de qualidade. Para tanto, adotou-se uma abordagem metodológica qualitativa, mediante análise de documental de diversos artigos e livros, que discutem e aprimoram a temática, contribuindo significativamente para esta reflexão. Portanto, este trabalho servirá como contributo, em meio a tantos outros que já foram apresentados no âmbito educacional, para pensar sobre a educação e educador que sejam facilitadores para a construção de conhecimentos capazes que abram novos horizontes locais e globais, e, ao mesmo tempo, colaborando na produção de indicadores para um educar e de qualidade.
Liderança nas Altas Habilidades/ Superdotação no Município de Vitória-ES
Authors: Vieira Valdineia Tiengo , Araújo Márcia Moreira de
Published: March 2024

Esta pesquisa objetiva acompanhar o cotidiano ativo dos trabalhadores especializados na educação especial com os alunos e alunas que apresentam traços de superdotação com manifestação de liderança. Para fundamentar a pesquisa foram usados os seguintes referenciais teóricos que norteiam a superdotação e as altas habilidades: Teoria da liderança transformacional, que sugere que os líderes que são capazes de inspirar e motivar seus seguidores a trabalhar em prol de objetivos mais elevados são mais eficazes do que aqueles que simplesmente fornecem instruções e diretrizes, a teoria das inteligências múltiplas de Howard Gardner(1983), que sugere que existem vários tipos de inteligências, incluindo linguística, lógico-matemática, espacial, musical, corporal-cinestésica, interpessoal e intrapessoal, e a obra de Zenger e Folkman (2014) de competências de liderança: Zenger e Folkman (2014), identifica 16 competências-chave que são importantes para líderes eficazes, incluindo comunicação, tomada de decisão, resolução de conflitos e influência. Esse modelo pode ser útil para entender as habilidades de liderança específicas que líderes superdotados e com altas habilidades possuem. A metodologia de pesquisa inclui a observação participante com questionários e análise documental. A produção de dados ocorrerá através de análise de conteúdo. Portanto, trabalharemos de forma a acompanhar as etapas que perpassam desde o diagnóstico, até a aplicação de atividades com vistas a desenvolver o potencial deste público-alvo da Educação Especial em Vitória, a partir das escolas de referência. Entrevistaremos quatro professores da educação especial. Os resultados esperados devem contribuir para o desenvolvimento da bibliografia pertinente sobre o tema, bem como facilitar o diagnóstico e a compreensão acerca desta manifestação da educação especial. Consideramos que ao compreender melhor as características, necessidades e potencialidades desses alunos superdotados com manifestação de liderança, podemos contribuir para a construção de um ambiente educacional mais inclusivo e enriquecedor. Isso não apenas beneficiará esses alunos, mas também a sociedade como um todo, ao aproveitar todo o potencial de liderança que esses jovens excepcionais podem oferecer para o progresso e a inovação em nossa comunidade educacional e além.
ІНСТИТУЦІОНАЛЬНІ АСПЕКТИ ЦИФРОВОЇ ТРАНСФОРМАЦІЇ ТА РОЗВИТКУ ЦИФРОВОЇ ЕКОНОМІКИ УКРАЇНИ
Authors: Храпкіна В.В.
Published: March 2024

У статті виокремлено прогнозовані позитивні результати цифрової трансформації. Охарактеризовано основні виклики та проблем подальшого розвитку цифрової економіки, що потребують уваги та вирішення. Запропоновано комплексний підхід до інституціонального розвитку цифрової економіки, що охоплює інституціоналізацію правових норм та стандартів, розвиток політичних та економічних стратегій, створення інфраструктури та забезпечення освітньої підтримки, спрямованих на використання потенціалу цифрових технологій, а також міжнародну співпрацю для забезпечення сталого та інклюзивного розвитку цифрової економіки шляхом залучення державних, приватних та громадських інституцій до створення умов, сприятливих для сталого розвитку та інтеграції цифрових інновацій у всі сфери життя. Визначено вектори інституціонального розвитку цифрової економіки: сприяння інноваціям та технологічному розвитку; забезпечення правової та регуляторної визначеності; створення сприятливого інвестиційного клімату; підвищення цифрової грамотності населення; забезпечення соціальної інклюзивності та зменшення цифрового розриву; адаптація до глобальних змін та викликів. Визначено ключові каталізатори цифрового прогресу в економіці: впровадження принципів Індустрії 4.0, концепції «розумна фабрика» та «кіберфізична система».
Análise da ocorrência de Infecções Sexualmente Transmissíveis em mulheres que fazem sexo com outras mulheres: revisão sistemática
Authors: Ribeiro Brunna Alexandra , Barbosa Gustavo Carrijo , Cunha Katiane Costa , Silva Marianne Lucena
Published: March 2024

Com objetivo de analisar estudos que abordam a ocorrência de infecções sexualmente transmissíveis entre mulheres que fazem sexo com mulheres, esta revisão sistemática foi realizada por meio de busca em bases de dados, mediante auxílio da escala de Newcastle-Ottawa para análise do risco de viés. Foram encontrados 30 artigos, em que a média de idade entre as participantes foi de 28,2 anos, com predomínio do ensino médio (60%) e etnia branca (60%). As infecções sexualmente transmissíveis mais prevalentes foram por Papilomavírus Humano (37%), Vaginose Bacteriana (20%) e Herpes (13%). Entre a amostra, 7,36% relataram o uso de algum método de barreira e 14% já haviam sido diagnosticadas com alguma infecção. Apesar da idade e do alto nível de escolaridade, a falta de conhecimento da amostra sobre as formas de contágio e prevenção de infecções sexualmente transmissíveis se mostra uma realidade.
Studying the genetic basis of ecological interactions with intergenomic epistasis
Authors: Hablützel Loraine , Bank Claudia
Published: March 2024

In a community, the phenotype or fitness of a focal genotype of one species can depend on the genotypes of other species. Such between-species genetic interactions are increasingly referred to as intergenomic epistasis, analogous to the classical definition of (intragenomic) epistasis in genetics. Here, we propose the first mathematical definition of intergenomic epistasis, which formalises the minimal conditions for the existence of inter-species genetic interactions. By discussing empirical studies of interacting species from the literature, we argue that intergenomic epistasis is a useful umbrella concept that engulfs multiple co-evolutionary relationships of interacting species, such as genotype-specific or gene-for-gene interactions. Consequently, intergenomic epistasis can be asserted in a study system when (i) the specific ecological interactions are unknown, (ii) the genetic basis of between-species interactions is unidentified, or (iii) the underlying genetic architecture is complex and involves genetic interactions within and between genomes. Moreover, the term itself highlights the importance of genetic factors in the study of ecological interactions, thus encouraging links between research in genetics and ecology. Finally, we argue how models incorporating intergenomic epistasis may facilitate the study of co-evolution.
Multiple Sclerosis in Comparison to Sporadic Multiple Sclerosis in Iraqi Patients
Authors: Khaleel Ali Mohammed , Al-Mashetah Sarmad Abdul-Rasool
Published: March 2024

Multiple Sclerosis (MS) is a complex autoimmune disease affecting the central nervous system, characterized by diverse symptoms based on lesion locations. Familial MS (FMS) indicates a genetic predisposition, potentially leading to a more severe disease course than sporadic MS, which lacks familial clustering. This distinction is critical for diagnosing and treating MS, particularly in the Iraqi patient population. The study aims to evaluate and compare the clinical and radiological features of FMS and sporadic MS among patients at the Baghdad Teaching Hospital's MS outpatient clinic. In this observational retrospective cross-sectional study, conducted from July 1, 2023, to December 31, 2023, at the Baghdad M.S outpatient clinic within the Medical City complex in Baghdad, Iraq, 100 MS patients were enrolled, with an equal division between FMS (n=50) and sporadic MS (n=50) cases. Participants were selected based on a definitive MS diagnosis, with FMS patients having a first or second-degree relative with MS. Data were collected via a questionnaire focusing on demographics, clinical presentations, MRI findings, and EDSS scores. Analysis was performed using SPSS version 26, employing Pearson Chi-square tests and Fisher's Exact test, with significance set at P ≤ 0.05. The demographic analysis revealed a predominant female representation (89%), with a significant age range between 20-30 years (48%). Time to diagnosis was notably longer for FMS cases, averaging 25.235 months, compared to 10.295 months for sporadic cases (P=0.002). Clinical presentations did not significantly differ between groups, but FMS cases exhibited greater disability severity, with higher EDSS scores indicating moderate to severe disability in 31% of FMS cases compared to only 19% in sporadic cases (P=0.035). MRI findings showed a higher prevalence of spinal cord and corpus callosum lesions in FMS (P=0.001 and P=0.027, respectively), with no significant differences in juxtacortical, cortical, or infratentorial lesions. This study illuminates that MS mainly affects females in their twenties and thirties, with familial MS cases taking longer to diagnose than sporadic ones. Familial cases exhibited more severe disabilities and more lesions in the spinal cord and corpus callosum. This indicates a complex interplay between genetics and MS, underscoring the importance of further research to enhance our understanding of the disease.
Antimicrobial Resistance and the Prevalence of the Panton-Valentine Leukocidin Gene among Clinical Isolates of Staphylococcus aureus in Lithuania
Authors: Kirkliauskienė Agnė , Kriščiūnas Jonas , Miciulevičienė Jolanta , Radzišauskienė Daiva , Kačergius Tomas , Bratchikov Maksim , Kaplerienė Lina
Published: March 2024

This study aimed to determine resistance to antimicrobials of Staphylococcus aureus strains isolated from clinical specimens in Lithuanian hospitals and to identify the genes conferring resistance and virulence. The study was carried out from June 2019 to September 2021. S. aureus strains were isolated from skin, soft tissues, blood, lower respiratory tract, urine and other specimens. Antibiotic susceptibility testing was performed using the disc diffusion method according to EUCAST guidelines. All isolates were analyzed for detection of the ermA, ermC, mecA, mecC, tetK, tetM, and lukF-PV genes by multiplex real-time PCR. The 16S rRNA coding sequence was applied as an internal PCR control. Altogether, 745 S. aureus strains were analyzed. Antimicrobial susceptibility testing revealed that all isolates were susceptible to rifampin and vancomycin. Of the 745 strains, 94.8% were susceptible to tetracycline, 94.5% to clindamycin, and 88.3% to erythromycin. The lowest susceptibility rate was found for penicillin (25.8%). Six percent of the tested strains were methicillin-resistant S. aureus (MRSA). The majority of methicillin-resistant strains were isolated from skin and soft tissues (73.3%), with a smaller portion isolated from blood (17.8%) and respiratory tract (8.9%). The ermC gene was detected in 41.1% of erythromycin-resistant S. aureus strains, whereas ermA was detected in 32.2% of erythromycin-resistant S. aureus strains. 69.2% of tetracycline-resistant S. aureus strains had tetK gene, and 28.2% had tetM gene. 7.3% of S. aureus isolates harbored lukF-PV gene. The frequency of the pvl gene detection was significantly higher in MRSA isolates than in methicillin-susceptible S. aureus isolates (p < 0.0001).
Biocontrol and Growth Promotion Potential of Bacillus subtilis CTXW 7-6-2 against Rhizoctonia solani that Causes Tobacco Target Spot Disease
Authors: Huang Ning , Jin Xin , Wen Jin-Tao , Zhang Yi-Fei , Yang Xu , Wei Guang-Yu , Wang Yi-Kun , Qin Min
Published: March 2024

Fungal diseases form perforated disease spots in tobacco plants, resulting in a decline in tobacco yield and quality. The present study investigated the antagonistic effect of Bacillus subtilis CTXW 7-6-2 against Rhizoctonia solani, its ability to promote the growth of tobacco seedlings, and the expression of disease resistance-related genes for efficient and eco-friendly plant disease control. Our results showed that CTXW 7-6-2 had the most vigorous growth after being cultured for 96 h, and its rate of inhibition of R. solani growth in vitro was 94.02%. The volatile compounds produced by CTXW 7-6-2 inhibited the growth of R. solani significantly (by 96.62%). The fungal growthinhibition rate of the B. subtilis CTXW 7-6-2 broth obtained after high-temperature and no-high-temperature sterile fermentation was low, at 50.88% and 54.63%, respectively. The lipopeptides extracted from the B. subtilis CTXW 7-6-2 fermentation broth showed a 74.88% fungal growth inhibition rate at a concentration of 100 mg/l. Scanning and transmission electron microscopy showed some organelle structural abnormalities, collapse, shrinkage, blurring, and dissolution in the R. solani mycelia. In addition, CTXW 7-6-2 increased tobacco seedling growth and improved leaf and root weight compared to the control. After CTXW 7-6-2 inoculation, tobacco leaves showed the upregulation of the PDF1.2, PPO, and PAL genes, which are closely related to target spot disease resistance. In conclusion, B. subtilis CTXW 7-6-2 may be an efficient biological control agent in tobacco agriculture and enhance plant growth potential.
A Mendelian Randomization Study: Roles of Gut Microbiota in Sepsis – Who is the Angle?
Authors: Bian Yeping , Xu Jian , Deng Xiaojing , Zhou Suming
Published: March 2024

Gut microbiota (GM) is a crucial underlying player during sepsis pathogenesis. However, the causal relationship is unclear and remains to be determined. A two-sample Mendelian randomization study was implemented. The statistical data about sepsis together with GM summarized from genome-wide association studies were evaluated. Instrumental variables were defined as single-nucleotide polymorphisms with prominent correlations with exposure. The inverse-variance-weighted test was employed as a major approach of Mendelian randomization analysis to estimate of causal relationships. The inverse-variance-weighted analysis results demonstrated that at different taxa levels, Actinobacteria and Bifidobacteriaceae influence sepsis. Actinobacteria had negative relationships to sepsis risk at the phylum (β = –0.34, SE = 0.10, p = 0.0008) and class (β = –0.23, SE = 0.07, p = 0.0011) levels in outcome coded ieu-b-69. Actinobacteria at the phylum level (β = –0.22, SE = 0.10, p = 0.027) was also negatively associated with sepsis in outcome coded ieu-b-4980. Bifidobacteriaceae at the order (β = –0.20, SE = 0.06, p = 0.0021), family (β = –0.20, SE = 0.06, p = 0.0021), and genus (β = –0.20, SE = 0.06, p = 0.0007) levels were all negatively correlated with the risk of sepsis in outcome coded ieu-b-69. The results of the Wald ratio model showed that Tyzzerella genus (OR (95%CI) = 0.6902[0.4907,0.9708], p = 0.0331) and Gastranaerophilales order (OR (95%CI) = 0.5907[0.3516,0.9926], p = 0.0468) were negatively connected with sepsis. This study implied at different taxa levels Actinobacteria and Bifidobacteriaceae, Tyzzerella genus, and Gastranaerophilales order have a causal relationship with sepsis, indicating that they are protective factors for the incidence of sepsis.
Molecular Detection of a Pathogenic Entamoeba among Symptomatic Children in Eastern Kurdistan of Iraq
Authors: Abdullah Sham Jamil , Ali Shahnaz Abdulkader
Published: March 2024

Entamoeba histolytica infects the large intestine of humans, causing a spectrum of clinical appearances ranging from asymptomatic colonization to severe intestinal and extra-intestinal disease. The parasite is identical microscopically to commensal nonpathogenic amoeba. To detect the pathogenic Entamoeba and estimate the precise prevalence of the parasite among the symptomatic pediatric population using molecular techniques. 323 fecal samples were collected from symptomatic children admitted to Sulaimani Pediatric Teaching Hospital, Sulaimaniyah Province, Iraq, from June to October 2021. A structured, validated questionnaire was prepared and used to report participants’ gender, residency, and drinking water source. Then, stool samples were microscopically examined, and the positive samples were submitted to molecular analysis by amplifying the 18s rRNA gene using nested PCR to differentiate E. histolytica from other nonpathogenic Entamoeba. Finally, gene sequences were done to confirm the species. Microscopically, 58 positive samples represented Entamoeba species infection rate of 18% among symptomatic patients. However, only 18 samples were positive for E. histolytica based on molecular methods, which accounts for 31% of the positive by microscopy and 5.6% among the 323 symptomatic populations. NCBI, available in their database, gives the gene sequence and accession number. Patients’ sociodemographic data and water sources were directly related to the infection rate. Classical microscopic examination provides a misleading profile about the prevalence of E. histolytica in an endemic region that might lead to unnecessary treatments and a lack of appropriate management for patients.
Tinjauan Awal Penyulang Palem di PT. PLN (PERSERO) UIWS2JB UP3 Jambi Menggunakan Software ETAP
Authors: Thamrin Nj. , Suprapto Eko , P Hadi
Published: March 2024

power flow in an electric power system is an event that flows in the form of active power (P) and reactive power (Q) from a generating system (sending side) through a transmission line or network until it reaches the load side (receiving side). . This power flow analysis has complicated stages if done manually, which requires an ETAP program. ETAP (Electric Transient Analysis Program) is software used to analyze an electric power system. This research was planned in the electrical engineering laboratory, Faculty of Engineering, Batanghari University, while the data was obtained from PT PLN (Persero) UIWS2JB Jambi. The ETAP method can simplify the calculation of the power flow in the palm feeder at PT PLN (Persero) Jambi.
Simulasi Aliran Daya Pada Pembangkitan PLTBG 1 MW Di Laboratorium Teknik Listrik Dengan Koneksi PLN Penyulang RA.01 Rantau Prapat Menggunakan Software Electric Transient And Analysis Program (Etap) 12.6.0
Authors: Wahyuni Kanthi , Thamrin Nj. , Dewi Rozlinda
Published: March 2024

PT Pangkatan Indonesia is an oil palm plantation company operating in Labuhanbatu Regency, North Sumatra Province, with a plantation area of 7,134.8 ha and has built a palm oil mill with an installed capacity of 40 tons / hour. Liquid waste from the plant has the potential to be an alternative source of raw materials for Biogas Power Plants (PLTBg) which is also a distributed generation (DG). The parameters to be studied in this study are the decrease in power losses and the voltage profile of the electrical power produced. The simulation process produces voltage under normal conditions, which only increases about 0.3% of the nominal voltage (complies with Ministerial Regulation No. 4 of 2009). In addition, the results of interconnection analysis at the 1 MW PLTBG show that the voltage at the ends before and after the connection has increased. Furthermore, the ratio of the total current before and after (load 75% - 95% ) is fixed (no change). The conclusion of the results of this study is, the greater the load, the greater the power produced.
Pengaruh Keadilan Distributif Budaya Organisasi Kepuasan Kerja Terhadap Komitmen Afektif pada Pegawai BKAD Kabupaten Kulon Progo
Authors: Wijayanti Nooria Kuncoro , Prayekti Prayekti , Kirana Kusuma Chandra
Published: March 2024

This research was conducted with the aim of knowing the effect of distributive justice, organizational culture, job satisfaction on affective commitment. The method used in this research is to use quantitative methods. Data collection techniques in this study used a questionnaire method. The population in this study were employees of the Badan Keuangan dan Aset Daerah (BKAD) of Kulon Progo Regency. The sampling technique used a non-probability model with a total sample of 57 employees of the Badan Keuangan dan Aset Daerah (BKAD) of Kulon Progo Regency. From the T test, the results of distributive justice (X1) have a significant effect on affective commitment (Y) with a sig. of 0.004 <0.05. Organizational culture (X2) has a significant effect on employee performance (Y) with a sig. of 0.000 < 0.05. and job satisfaction (X3) has a significant effect on affective commitment (Y) with a sig. of 0.009 <0.05.
Pengaruh Penyuluhan Tentang Stunting Terhadap Pengetahuan dan Sikap Ibu yang Memiliki Balita di Posyandu Melati Desa Lambur 2
Authors: Yuristina Amanda
Published: March 2024

Stunting in children is a chronic nutritional problem due to inadequate nutritional intake in the long term combined with infectious diseases in children and environmental problems. Stunting needs special attention because it can increase the risk of death in children, and hinder children's physical and mental development. Lack of nutritional knowledge or lack of applying nutritional knowledge in daily life can cause nutritional problems. Malnourishment in children can be caused by the attitude or behavior of parents, especially mothers who are a factor in choosing food that is not correct, choosing food ingredients, the availability of sufficient quantities of food and the variety of types of food is influenced by the level of knowledge of mothers about food and nutrition. Mother's attitude is greatly influenced by her knowledge.This study used a one group pretest-posttest design in October 2022 at Posyandu Melati, Lambur Village 2. The total population was 187 respondents with a sample using simple sampling 30 respondents. Data analysis used the t test. The results of this study found that there was an effect of counseling about stunting on the knowledge (p-value 0.008) and attitude (p-value 0.000) of mothers who had toddlers at Posyandu Melati Lambur 2 Village.The conclusion obtained in this study is that there is an influence of counseling about stunting on the knowledge and attitudes of mothers who have toddlers at Posyandu Melati, Lambur 2 Village.
Evaluasi Penerapan Sistem Informasi Manajemen Rumah Sakit (SIMRS) dengan Metode Hot Fit di RSU Mitra Sejati Medan
Authors: Hasibuan Rapotan , Layli Rayhan , Safitri Dedek , Anastasya Raihanis , Pertiwi Cindy
Published: March 2024

The Hospital Information System (SIMRS) is a system that integrates the collection, processing, reporting and use of data information needed to increase the efficiency and effectiveness of health services through better management at various levels of health services. The purpose of this research is to evaluate the implementation of the hospital management information system (SIMRS) at Mitra Sejati General Hospital with the Human Organization Technology (HOT) Fit Model method. The type of research used in this research is qualitative research with the Hot-Fit model method. The results of this study are that when viewed in terms of the human aspect, it is still not optimal, there are still many obstacles that occur in the field including the absence of an RME obligation, The organizational aspect is good, the hospital management has conducted training and is always holding retraining. The technological aspect is satisfactory enough for HR. Another obstacle that often occurs is related to the discipline of human resources for data input that is not in real time, SIMRS which is applied at Mitra Sejati General Hospital still has application deficiencies, the hospital management does not provide support in the form of repairs or strengthening the hospital network. Suggestions for hospitals need to develop medical records, HR discipline, develop existing SIMRS and improve network constraints.
Pengaruh Audit Komunikasi Media Sosial Instagram @Kemenkominfo terhadap Kepuasan Pengguna
Authors: Wulandari Charisma Dina , Intyaswati Drina
Published: March 2024

This research aims to find out whether communication on the social media Instagram @kemenkominfo has an effect on user satisfaction. This research used a sample of 50 @kemenkominfo Instagram users who communicated either via Instagram DM or the comments column. The indicators used in the communication variable are understanding, enjoyment, influence on attitudes, improved relationships and action. Indicators of user satisfaction variables are conformity to expectations, interest in revisiting and willingness to recommend. Using a Likert scale quantitative method and analyzed using Smart PLS 3.0. The results of this research state that communication has a positive effect on user satisfaction on Instagram @kemenkominfo, amounting to 69.5% of user satisfaction being influenced by communication variables, while the remaining 30.5% is influenced by other variables.
Pengaruh Brand Ambassador Park Hyung Sik Terhadap Brand Image Avoskin
Authors: Nursafitri Nilam , Putri Berlian Primadani Satria
Published: March 2024

This study aims to determine and analyze whether there is influence and how much brand ambassador Park Hyung Sik has on Avoskin's brand image. Data collection in this study was carried out using quantitative methods including descriptive analysis, regression test, coefficient of determination, hypothesis, and validity and reliability. This research was conducted using a quantitative type method, with descriptive and associative properties because it is able to provide an explanation regarding the relationship between the two variables, namely brand ambassadors to brand image. In this study, the technique used in data collection used a survey method by distributing questionnaires via Google Form. The results in this study showed a positive influence on Brand Ambassador Park Hyung Sik (X) on Brand Image Avoskin (Y), with simple linear regression results with a value of 1.420. Therefore, when the value increases by 1%, the Brand Ambassador will increase by 1.420 and the Brand Image variable will also increase by 6258.905. This proves that the value of the Brand Ambassador has grown, so the Brand Image has also increased. The research was conducted using the Viscap model.
Analisis Ketersediaan Kedelai Pada Koperasi Karya Mulya desa Sepande Kabupaten Sidoarjo
Authors: Layllindra Fasya Arifatin , Soedarto Teguh , Syah Mirza Andrian
Published: March 2024

Karya Mulya Cooperative is a cooperative that provides soybean raw materials for tofu and tempeh craftspeople in Sepande Village, Sidoarjo Regency. This study aims to determine the optimal amount of soybean raw material inventory that should be carried out by Koperasi Karya Mulya, the optimal frequency of purchasing raw materials, the right time to purchase raw materials, the optimal total ordering cost made for the procurement of soybean raw materials, and the implementation of an effective and efficient warehouse management system. This type of research is descriptive quantitative by describing the control of raw material inventory carried out by cooperatives through data obtained and then analyzed. Data analysis used includes Economic Order Quantity (EOQ), Reorder Point (ROP), Safety Stock (SS), and FIFO methods. Based on the results of the analysis using the EOQ method, Koperasi Karya Mulya should order an optimal raw material frequency of 6,459.14 tons with a purchase frequency of 210 times, ROP 7.009,25  tons, Safety Stock of 5.857,81 tons and total storage costs of Rp427,272,734.03.
Pengaruh Pelayanan Online oleh Disdukcapil Terhadap Kepuasan Masyarakat Kota Cimahi
Authors: Pasya Mochammad Kemal Maulana , Soesilo Soesilo , Suryaman Warman
Published: March 2024

Public services, especially the quality or level of service provided by government employees to the community, is often one of the problems that often arise in public relations with local governments. Service standards that must be offered by the government as a provider of public goods and services have increased. The Cimahi City Population and Civil Registry Office is a local government organization that has the responsibility of making residence documents for various kinds of goods needed by the community. The research objective is to find out the effect of online services by Disdukcapil on community satisfaction. The method used is quantitative with a total of 31 respondents. The analysis technique used statistical analysis through regression, correlation, determination, and hypothesis testing. The results show that online services (X) have a simultaneous effect on community satisfaction (Y). The remaining 14.3% is influenced by other factors that are not present in this study. This shows that the better the online services provided by officials at the Population and Civil Registration Service, the more people's satisfaction will increase.
Penyederhanaan Birokrasi pada Dinas Perpustakaan dan Kearsipan Daerah Provinsi Jawa Barat
Authors: Masitoh Siti , Kushendar Deden Hadi , Mulawarman Aditia
Published: March 2024

Simplification in the bureaucracy is one of the focuses of the 5 (five) priority programs of the Onward Indonesia Cabinet under the leadership of President Joko Widodo and Ma'ruf Amin and as a presidential mandate which is an executive order that must be carried out. We must continue to simplify the bureaucracy on a large scale. Investment for job creation must be prioritized. This study aims to determine the simplification of bureaucracy in the Regional Library and Archives Office of West Java Province. The method used in this study is qualitative by using data collection techniques by observing, interviewing and documenting. The results of this study are that the services available at the Regional Library and Archives Service of West Java Province are appropriate and in the alignment of administrative positions to functional positions because the simplification of the bureaucracy has the advantage that services become simpler, agile, fast and less verbose Regional Library and Archives Services West Java Province simplified the bureaucracy on the basis of government policy with the aim of facilitating the delivery of services to the community more quickly.
Pengaruh Kualitas Layanan Terhadap Loyalitas Pelanggan yang Dimediasi oleh Kepuasan Pelanggan pada Sales Person Dealer Honda Studi WOM Cabang Jatibarang
Authors: Rafsanzani Mahdy Ardy , Saparso Saparso , Teecoalu Melitina
Published: March 2024

WOM Finance is one of the multi-finance companies in Indonesia whose growth continues to increase. To be able to survive in the increasing competition in the field of financing services, Wom Finance continues to improve service quality which is expected to provide satisfaction value for customers and impact on customer loyalty to continue using financing services from Wom Finance. The purpose of this study was to determine and analyze the effect of service quality variables on customer loyalty mediated by customer satisfaction with a focus study on sales persons at Honda dealers in collaboration with the Jatibarang branch of Wom Finance. The number of respondents in this study were 73 respondents. The analysis technique used in this study is Path Analysis. The results of the analysis show that service quality has a positive effect on customer satisfaction and customer loyalty, customer satisfaction has a positive effect on customer loyalty but is not proven to have a positive effect on mediation relationships. The results of this study are expected to be a reference for Wom Finance and for companies in similar fields so that they are able to maintain and always improve service quality so that it has an impact on customer satisfaction and loyalty.”
Perancangan Strategi Berdasarkan Analisis Pengaruh Rasio Keuangan dan Rasio Pasar terhadap Harga Saham (Studi Kasus pada Perusahaan Indeks IDX30 di Bursa Efek Indonesia Tahun 2016-2022)
Authors: Nurrahman Ahmad Rizky , Chumaidiyah Endang , Zulbetti Rita
Published: March 2024

Investment has played a crucial role in driving Indonesia's economic growth post Covid-19 pandemic, notably contributing to the IDX30 index and witnessing a rise in investor numbers. The aim of this study was to uncover trends and the influence of financial and market ratios on stock prices, both concurrently and partially. Another aim also offers recommendations for investors and companies to optimize investment benefits and enhance future corporate performance. The sample for this research comprises 9 companies listed in the IDX30 index for the years 2016-2022. The data utilized encompasses secondary data, processed using panel data regression, and primary data collected through an AHP questionnaire. The findings of this study revealed that trends of ROE, CR, PBV, and HS show a decreasing trend, while DER and EPS indicate an increasing trend. ROE, CR, DER, EPS, and PBV collectively exert a significant impact on stock prices. Furthermore, partial effects showed that ROE, EPS, and PBV significantly affect stock prices. Enhanced performance strategies for companies, both internally and externally, are formulated using IFAS and EFAS, followed by their integration into a SWOT matrix. These results are used to recommend strategies for investors and companies to optimize investments and overall corporate performance.