bluuebunny/crossref_metadata_2025 huggingface dataset:
Information Content of Hydrologic Data across Space: Streamflow Predictions using Machine Learning
Authors: Gupta Abhinav
Published: December 2022

This study aimed to assess the usefulness of data from donor watersheds to predict streamflow in parent watersheds. For this purpose, Long-Short Memory Network (LSTM) is used as an information extraction algorithm. Data from a total of 434 watersheds were used in this study. Out of these 434 watersheds, 57 watersheds were selected as the parent watersheds. These 57 watersheds were those where streamflow statistical structure changed over the study period (1980-2013 water years). Several LSTM models were developed by using the different number of donor watersheds as training watersheds varying from 1 to 128. It was found that the optimal number of training watershed were much less than 128 for most of the parent watersheds. Increasing the number of donor watersheds beyond this optimal value resulted in a statistically insignificant gain in accuracy. In some cases, the Nash-Sutcliff Efficiency (NSE) decreased, albeit only slightly, when the number of donor watersheds for training increased beyond the optimal value. However, we also found that using data from more watersheds beyond the optimal number of training watersheds results only in a slight decrease in NSE. Therefore, one bears only a small cost by training LSTM against a large number of watersheds compared to the optimal number of watersheds. The results of this study contradict the prevalent idea that LSTM continues to extract hydrologically relevant information as more and more data are fed to the model; this was true only for a few of the 57 parent watersheds used in this study.
An efficient Bayesian observer model of attractive and repulsive temporal context effects when perceiving multistable dot lattices
Authors: Van Geert Eline , Ivancir Tina , Wagemans Johan
Published: December 2022

In multistable dot lattices, the orientation we perceive is attracted towards the orientation we perceived in the immediately preceding stimulus and repelled from the orientation for which most evidence was present previously (Van Geert, Moors, Haaf, & Wagemans, 2022). Theoretically-inspired models have been proposed to explain the co-occurrence of both context effects in multistable dot lattice tasks, but these models artificially induced an influence of the previous trial on the current one without detailing the process underlying such an influence (Gepshtein & Kubovy, 2005; Schwiedrzik et al., 2014). We conducted a simulation study to test whether the observed attractive and repulsive context effects could be explained with an efficient Bayesian observer model (Wei & Stocker, 2015). This model assumes variable encoding precision of orientations in line with their frequency of occurrence (i.e., efficient encoding) and takes the dissimilarity between stimulus space and sensory space into account. An efficient Bayesian observer model including both a stimulus and a perceptual level was needed to explain the co-occurrence of both attractive and repulsive temporal context effects. Furthermore, this model could reproduce the empirically observed strong positive correlation between individuals' attractive and repulsive effects (Van Geert et al., 2022), by assuming a positive correlation between temporal integration constants at the stimulus and the perceptual level. To conclude, the study brings evidence that efficient encoding and likelihood repulsion on the stimulus level can explain the repulsive context effect, whereas perceptual prior attraction can explain the attractive temporal context effect when perceiving multistable dot lattices.
Sociopolitical influences on geographical judgments of locations and distances by Greek Cypriots and Turkish Cypriots living in Cyprus
Authors: Galati Alexia , Plastira Miria , Friedman Alinda , Avraamides Marios N
Published: December 2022

Many non-geographic factors influence spatial judgments of real-world locations, which implies that spatial representations are not metrically veridical. We investigated the influence of social and ethnic factors on geographical judgments in the geopolitical context of Cyprus – an island divided since 1974 into the Turkish Cypriot and Greek Cypriot communities in the north and south, respectively. Participants from each community (249 Greek Cypriots, 322 Turkish Cypriots) indicated their familiarity with 19 towns (town knowledge task), and estimated the locations of those towns (location estimation task) and the straight-line distance between them (distance estimation task). In questionnaires, they also rated their attitudes toward the other community. Cypriots underestimated distances and contracted the relative locations of towns within the other community more so than within their own community. Moreover, Cypriots who were more willing to live together with Cypriots from the other community (i.e., perceiving less social distance) underestimated distances between towns, whereas those less willing to live together overestimated distances. The results support the notion that representations of global-scale environments have multi-faceted origins, which include social factors (e.g., ethnic identity, political attitudes) that are not usually associated with spatial representations.
“This Behavior Strikes us as Ideal”: Assessment and Anticipations of Huisman (2022)
Authors: Sarafoglou Alexandra , Bartoš František , Stefan Angelika Marlene , Haaf Julia M. , Wagenmakers Eric-Jan
Published: December 2022

Huisman (2022) argued that a valid measure of evidence should indicate more support in favor of a true alternative hypothesis when sample size is large than when it is small. Bayes factors may violate this pattern and hence Huisman concluded that Bayes factors are invalid as a measure of evidence. In this brief comment we call attention to the following: (1) Huisman's purported anomaly is in fact dictated by probability theory; (2) Huisman's anomaly has been discussed and explained in the statistical literature since 1939; the anomaly was also highlighted in the Psychonomic Bulletin & Review article by Rouder et al. (2009), who interpreted the anomaly as ``ideal'': an interpretation diametrically opposed to that of Huisman. We conclude that probability theory is a safer guide to scientific practice than human intuition.
Investigating the moderating role of socioeconomic status in the relationship between music education and auditory discrimination
Authors: Bahmani Bahare
Published: December 2022

Studies show that music training and socioeconomic status are related to children's learning of language. Learning a language has different parts. One of the essential parts of learning a language is auditory discrimination. Auditory discrimination plays a vital role in language acquisition and especially comprehension skills. In this study, we investigated the moderating role of socioeconomic status in the relationship between the duration of music training and auditory discrimination in children. Previous studies have shown that music training at an early age can improve language acquisition. Most studies on this subject have been conducted in Western countries, and not many studies have been done in other cultures. Eighty-six participants between 6 to 10 without or with 3 to 72 months of prior experience in music training were selected and examined by available sampling from music institutes and schools in Mashhad. Auditory discrimination was measured using the Wepman auditory discrimination test, and for estimating socioeconomic status, parents were asked to fill Ghodrat Nama socioeconomic questionnaire. We determined that socioeconomic status significantly modulates the relationship between the duration of music training and auditory discrimination. The present study shows the role of cultural differences and socioeconomic status in examining the relationship between the duration of music training on human language abilities.
Learning in school or because of school? Migration gaps in achievement and the role of schools
Authors: Passaretta Giampiero , Skopek Jan
Published: December 2022

Are schools engines of integration? Our study examines the learning outcomes of first-grade students from immigrant versus native families in Germany. We use a differential exposure approach to decompose learning over the school year into two causally distinct components: learning by exposure to schooling (school factors) a vis learning by being older at test (non- school factors). Data came from the nationally representative National Educational Panel Study. Our results demonstrate the importance of school exposure for learning but indicate no support for the idea that schools reduce migration-related inequality in achievements. Children from non-western immigrants, who experiences the largest penalties, progress in learning at lower rates compared to other immigrant groups. Non-westerners’ decelerated learning is entirely explained by the low benefits of schooling. We conclude that German primary schools do not work as engines of integration because immigrant groups with the largest educational disadvantage benefit the least from school exposure.
Modelling the spatial diffusion of past populations – a cellular automata approach
Authors: Hewitt Richard J
Published: December 2022

The paper presents a simple directed cellular automata model for the R environment, applied to model the spatial diffusion of a hypothetical past hominin population. At the model start time, an agent (individual or group) occupies a cell, and scans the cell neighbourhood for the most suitable next step. A cost function is implemented whereby the agent will choose the minimum slope within the neighbourhood at each step, but this could be any other suitability surface that might influence an agent's movement decisions, i.e water, game, vegetation etc. The model could be applied at any spatial or temporal scale, from migrations out of an occupation site over a number of days, to an ocean voyage measured in weeks or months, to a species dispersion event measured in millennia. The model could also be applied to practically any dispersion case for which data are available, e.g. viruses, vegetation or airborne particles. Full R script code and data required to run the model are provided as supplementary material.
Description of the disease patterns, treatment results and some related factors of patients at the Department of Neurology, Military Central Hospital 108 from 2017 to 2021
Authors:   108 Military Central Hospital, Le Thi Que , Nguyen Thanh Tung ,   108 Military Central Hospital, Dao Thi Thuy Ngoc ,   108 Military Central Hospital, Nguyen Bich Phuong ,   108 Military Central Hospital, Phan Khanh Ly ,   108 Military Central Hospital, Nguyen Thi Kim Ngoc ,   108 Military Central Hospital
Published: December 2022

This study aimed to describe the disease patterns, treatment results and some related factors of patients at the Department of Neurology, Central Military Hospital 108 in 05 years from 2017 to 2021. The descriptive cross-sectional method was used to study 9,401 patients. Results showed the rate of patients entering treatment was classified into 3 age groups, in which 2 groups had a high rate of 16-59 and over 60 years old. However, it is mainly in the age group from over 60 years old, whose rates from 2017 to 2021 are >50, respectively. The incidence in men over the years is higher than in women and accounts for over 50%. The percentage of patients using health insurance cards tends to increase gradually over the years, all >90%, especially in 2020, reaching 96.61%. The percentage of patients in the group with indications for internal medicine treatment accounted for the main percentage (>95%). The average treatment day in the group >10 days tended to decrease over the years. The percentage of patients admitted to hospital for treatment is mainly in the age group over 60 years old. The rate of cure and reduction when indicated for hospital discharge in 5 years reached >97% and the mortality rate ≤0.5%.
Chemical composition and biological activity of leaf extracts of Adinandra bockiana E. Pritz. ex Diels
Authors:   Department of Biology, Thai Nguyen University of Education, Nguyen Huu Quan , Nguyen Thi Ngoc Lan ,   Department of Biology, Thai Nguyen University of Education, Nguyen Thi Thu Nga ,   Department of Biology, Thai Nguyen University of Education, Sy Danh Thuong ,   Department of Biology, Thai Nguyen University of Education, Chu Hoang Mau ,   Department of Biology, Thai Nguyen University of Education
Published: December 2022

Adinandra bockiana E. Pritz. ex Diels collected in Lao Cai province,Vietnam belongs to the Adinandra genus. Some species of the genus Adinandra have been studied for their botanical characteristics and bioactive compounds, however, A. bockiana has not been studied to date. Therefore, studying the chemical composition and biological activity of A. bockianaleaf extracts is pioneering and necessary in reality. The leaf extracts of A. bockiana have been quantified and determined to contain tannins, coumarins and polyphenolic compounds. The ethanol extract, dichloromethane extract and ethyl acetate extract at the concentrations 20, 60, and 200 μg/mlcan inhibit the growth of B. subtilis, L. plantarum, and S. marcescens. The ethanol extract, dichloromethane extract and ethyl acetate extract have free radical reduction activity, which EC50 values reached 0.2, 0.47, and 5.7 μg/ml, respectively. The ethanol extract exhibited inhibitory activities on gastric, lung, and breast cancer cell lines with IC50 values of 58.62, 48.73, and 43.15 μg/ml, respectively. The results show that A. bockiana is a potential plant that contains many compounds that have antibacterial, antioxidant, and anticancer activities.
Evaluating inhibitory activity of bioactive compounds from Andrographis paniculata against the molecular targets of the SARS-CoV-2 virus by using the molecular docking method
Authors:   University of Medicine and Pharmacy, Vietnam National University, Hanoi, Ta Thi Thu Hang , Nguyen Bao Kim ,   University of Medicine and Pharmacy, Vietnam National University, Hanoi, Nguyen Hong Nhung ,   University of Medicine and Pharmacy, Vietnam National University, Hanoi, Vu Khanh Linh ,   University of Medicine and Pharmacy, Vietnam National University, Hanoi, Do Thi Hong Khanh ,   University of Medicine and Pharmacy, Vietnam National University, Hanoi, Phan Van Ngo ,   Quang Binh Pharmaceutical Joint Stock Company, Nguyen Thanh Hai ,   University of Medicine and Pharmacy, Vietnam National University, Hanoi, Bui Thanh Tung ,   University of Medicine and Pharmacy, Vietnam National University, Hanoi
Published: December 2022

Covid-19 is an infectious disease associated with acute respiratory infections caused by the SARS-CoV-2 virus. Its entrance and infection mechanisms have been identified as S protein, main protease (Mpro or 3CLpro), angiotensin-converting enzyme 2 (ACE2), and RNA-dependent RNA polymerase (RdRp). As a result, they are critical targets in the prevention of SARS-CoV-2 viral infection. Andrographis paniculata has been shown to be potentially effective in the treatment of several viruses. This study evaluated the inhibitory effects of compounds in Andrographis paniculata against the S protein, 3CLpro, ACE2, and RdRp targets by molecular docking method. The 3D structure of the SARS-CoV-2 RdRp, 3CLpro, S protein and ACE2 were obtained from the RCSB Protein Data Bank. Compounds were collected from the publication of Andrographis paniculataand these structures were obtained from the PubChem database. Molecular docking was done by AutoDock Vina software. Lipinski rule of five is used to compare compounds with drug-like and non-drug-like properties. Pharmacokinetic parameters of potential compounds were evaluated using the pkCSM tool. Based on previous publications of Andrographis paniculata, 22 main compounds were collected. The results showed that the compound 3-O-beta-D-Glucopyranosyl-14,19-dideoxyandrographolide had a strong inhibitory effect on both the RdRp and 3CLpro targets of SARS-CoV-2 virus. Analysis of Lipinski 5’s rule exhibited that 3-O-beta-D-Glucopyranosyl-14,19-dideoxyandrographolide has drug-likeness properties. In addition, the results of predicting pharmacokinetic parameters indicated that this compound had good intestinal absorption and low toxicity. The compound 3-O-beta-D-Glucopyranosyl-14,19-dideoxyandrographolide is a potential compound to become the therapeutic drug Covid-19 from Andrographis paniculata.
HUBUNGAN RELIGIUSITAS DENGAN PERILAKU MENYONTEK PADA SISWA KELAS X SMA LABORATORIUM UNIVERSITAS PGRI SEMARANG
Authors: Luthfiana Indah , Rakhmawati Dini , Yulianti Padmi Dhyah
Published: December 2022

Penelitian hubungan religiusitas dengan perilaku menyontek pada siswa kelas X SMA Laboratorium Universitas PGRI Semarang ini dilator belakangi oleh fenomena bahwa siswa ternyata tidak lepas dari perilaku menyontek. Hasil Analisis Angket Kebutuhan Peserta Didik menunjukkan rendahnya tingkat religiusitas siswa dan tingginya tingkat perilaku menyontek. Jenis penelitian ini adalah kuantitatif korelasi dengan metode survey. Populasi data penelitian sejumlah 96 siswa, meliputi kelas X MIPA 1, X MIPA 2, X IPS 1 dan X IPS 2. Sampel penelitian ini sejumlah 77 siswa yang diambil dengan teknik simple random samping. Alat pengumpulan data yang digunakan adalah skala religiusitas dan skala perilaku menyontek. Berdasarkan hasil penelitian menyatakan bahwa terdapat hubungan negatif yang signifikan antara religiusitas dengan perilaku menyontek siswa kelas X SMA Laboratorium Universitas PGRI Semarang. Artinya semakin tinggi tingkat religiusitas siswa semakin rendah tingkat perilaku menyontek siswa.Â Kata Kunci : Religiusitas, Perilaku Menyontek
HUBUNGAN SELF-EFFICACY DENGAN PENGAMBILAN KEPUTUSAN KARIER SISWA KELAS XI SMA INSTITUT INDONESIA
Authors: Bella Karina , Retnaningdyastuti Th. SR. , Ajie G. Rohastono
Published: December 2022

Permasalahan dalam penelitian ini adalah 1) Siswa memiki Pengambilan keputusan karier yang rendah?Â  2) Siswa-siswa belum memiliki rasa percaya dengan keputusan karier dan memiliki perasaan takut apabila karier yang diambinya salah sehingga menimbulkan self-efficacy? 3) Siswa-siswa belum sadar pentingnya hubungan self-efficacy dengan pengambilan keputusan karier? Tujuan yang hendak dicapai dalam penelitian ini adalah untuk mengetahui Pengambilan Keputusan Karier siswa dan mengetahui siswa yang belum memiliki rasa percaya dengan keputusan karier serta mengetahi hubungan self-efficacy dengan pengambilan keputusan karier. Jenis penelitian ini adalah penelitian kuantitatif korelasi dengan metode ex-post facto. Populasi data penelitian sejumlah 89 siswa, meliputi kelas XI MIPA 1, XI MIPA 2, XI MIPA 3, XI MIPA 4 dan XI MIPA 5. Sampel uji coba (Try Out) berjumlah 30 Siswa Kelas XI MIPA 1 dan XI MIPA 2. Hasil penelitian setelah uji cobaÂ  sejumlah 59 siswa yang diambil dengan teknik simple jenuh. Alat pengumpulan data yang digunakan adalah skala self-efficay dan yang digunakan adalah skala pengambilan keputusan karier. Hasil analisis angket self-efficacy siswa menunjukan kategori tinggi (79,7%) dengan jumlah frekuensi 47 siswa. Sedangkan siswa lain mempunyai tingkat self-efficacy sangat tinggi (1,7%) dengan jumlah frekuensi 1 siswa. Dan dalam kategori rendah (18,6%) dengan jumlah frekuensi 11 siswa. Kemudian tingkat pengambilan keputusan karier pada kategori sangat rendah dengan frekuensi sebanyak 16 siswa (27,1%) dan sisanya tingkat frekuensi 4 siswa (6,8%). Berdasarkan hasil penelitian menyatakan bahwa terhadap hubungan positif yang signifikan antara self-efficacy dengan pengambilan keputusan karier siswa kela XI SMA Institut Indonesia. Artinya semakin tinggi tingkat self-efficacy siswa semakin tinggi pengambilan keputusan karier.Kata Kunci : Self efficacy, Pengambilan Keputusan Karier
PENERAPAN OUTDOOR STUDY UNTUK MENINGKATKAN HASIL BELAJAR SISWA PADA MUATAN PELAJARAN SBDP DI SEKOLAH DASAR
Authors: Hikmah Nurul
Published: December 2022

Kurangnya pengenalan budaya daerah menjadikan banyaknya siswa yang kurang mengenali budaya daerah, termasuk ragam budaya di lingkungan tempat tinggal siswa. Hal ini ditandai dengan rendahnya hasil belajar siswa tentang karya seni rupa daerah pada muatan pelajaran SBdP hanya 7,4% siswa yang dapat memenuhi nilai KKM. Penelitian ini bertujuan untuk meningkatkan hasil belajar siswa dengan metode outdoor study pada muatan SBdP di SD Negeri Nitikan Semanu Gunung kidul. Penelitian ini merupakan penelitian deskriptif dengan pendekatan kualitatif. Tempat penelitian yaitu di Dusun Nitikan, Semanu, Gunungkidul, dengan objek penelitian 27 siswa yang merupakan siswa kelas V SD Negeri Nitikan. Data penelitian diperoleh dari laporan hasil wawancara, foto kegiatan, hasil karya seni rupa daerah yang dibuat oleh anggota kelompok, dan hasil belajar siswa tentang karya seni rupa daerah. Hasil penelitian menunjukkan adanya kenaikan hasil belajar siswa setelah menggunakan metode outdoor study. Siswa yang berhasil mencapai nilai KKM sebanyak 23 siswa atau 85,2% dari sebelum pemberian perlakuan. Keterampilan siswa dalam membuat karya seni rupa daerahpun meningka. Hal ini ditandai dengan hasil karya siswa yang dibuat secara berkelompok.Â
HUBUNGAN ANTARA LAYANAN BIMBINGAN DAN KONSELING DAN POLA ASUH ORANG TUA DENGAN MOTIVASI BELAJAR SISWA KELAS VIII SMP NEGERI 2 GAMPING, SLEMAN, YOGYAKARTA
Authors: Fajar Bayu Prasetya  , Nur Wahyumiani
Published: December 2022

Penelitian ini bertujuan untuk mengetahui (1) hubungan antara layanan bimbingan konseling dengan motivasi belajar siswa, (2) hubungan antara pola asuh orang tua dengan motivasi belajar siswa, (3) hubungan antara layanan bimbingan konseling dan pola asuh orang tua dengan motivasi belajar. Populasi penelitian ini adalah seluruh siswa kelas VIII di SMP N 2 Gamping, yang berjumlah 209 siswa. Pengambilan sampel dengan menggunakan teknik quota proporsional random sampling yakni sejumlah 60 siswa. Metode pengumpulan data dalam penelitian ini digunakan angket yang divalidasi dengan validitas konstruk. Teknik analisis data dengan menggunakan analisis regresi ganda. Hasil penelitian menunjukan bahwa (1) Ada hubungan positif dan signifikan antara layanan bimbingan konseling dengan motivasi belajar siswa, dengan mengetahui hasil perhitungan angka rx1y = 0,453 dengan p = 0,001 < 0,05, yang berarti semakin baik dan efektif pelaksanaan layanan bimbingan konseling diberikan terhadap siswa, maka semakin tinggi motivasi belajar siswa, (2) Ada hubungan positif dan signifikan antara pola asuh orang tua dengan motivasi belajar siswa dengan mengetahui hasil perhitungan angka rx2y = 0,432 dengan p = 0,001 < 0,05, yang berarti semakin baik pola asuh orang tua pada siswa maka motivasi belajar siswa akan meningkat dan semakin rendah kualitas pola asuh orang tua pada siswa, maka semakin rendah motivasi belajar siswa, (3) Ada hubungan positif dan signifikan antara layanan bimbingan konseling dan pola asuh orang tua dengan motivasi belajar siswa dengan mengetahui hasil perhitungan angka harga Fhitung = 12,776 dengan (p) 0,000 < 0,05, yang artinya semakin baik dan efektif pelaksanaan layanan bimbingan konseling dan semakin baik pola asuh orang tua terhadap siswa maka motivasi belajar siswa akan semakin meningkat. Implikasi dalam penelitian ini, sekolah, khusus guru bimbingan konseling memiliki peran penting dalam pelaksanaan layanan bimbingan konseling secara efektif dalam pemahaman pola asuh orang tua terhadap siswa yang positif sehingga dapat meningkatkan motivasi belajar dan tercapai tujuan pembelajaran di sekolah.
PENGARUH POLA ASUH ORANG TUA TERHADAP PERILAKU BULLYING SISWA SMP N 1 WEDUNG
Authors: Luthfiani Saputri
Published: December 2022

Permasalahan dalam penelitian ini adalah Perundungan atau bullying adalah tindakan negatif yang harus diintervensi dikarenakan lingkungan tersebut mampu mempengaruhi kepribadian seseorang di masa depan. Penelitian ini adalah penelitian kausalitas dengan pendekatan kuantitatif. Penelitian kausalitas bertujuan untuk menguji pengaruh dimana pada penelitian ini bertujuan untuk menguji secara statistic pengaruh pola asuh orang tua terhadap perilaku bullying menggunakan analisis regresi linier sederhana. Hasil penelitian menunjukkan bahwa Pola asuh pada siswa SMP N 1 Wedung mayoritas siswa mengalami pola asuh orang tua yang baik sebanyak 96 orang (68.1% ) dan kurang baik sebanyak 45 orang (31.9). Kesimpulannya orang tua siswa tersebut baik dalam memperhatikan anaknya. Perilaku bullying pada sekolah SMP N 1 Wedung mayoritas siswa tidak mengalami ada perilaku bullying pada siswa SMP N 1 Wedung sebanyak 141 orang sebanyak (100%). Kesimpulannya lebih banyak tidak ada perilaku bullying pada sekolah SMP N 1 Wedung Hasil analisis ini menunjukkan bahwa nilai signifikansi pola asuh terhadap perilaku bullying sebesar 0,000.
МОДЕЛЮВАННЯ ДІАГНОСТИКИ ОБ'ЄКТІВ МАШИНОБУДУВАННЯ ДЛЯ ОПТИМІЗАЦІЇ ЇХ ЖИТТЄВОГО ЦИКЛУ
Authors: Ковалевський С.В. , Сидюк Д.М.
Published: December 2022

Метою дослідження є створення методики діагностики стану об’єктів на підставі удосконалення перетворення координат станів та їх класифікації.

Дослідження з розробки системи розпізнавання для вдосконалення діагностики об’єктів проводиться на основі вирішення задачі «виключаюче «але»» зі застосуванням цільових функцій. У якості апробації застосовується аналіз частини виробництва з дванадцяти розглянутих факторів для тридцяти вох прецедентів.

Перетворення векторного простору дозволяє виконати розпізнавання образів багатовимірних об'єктів, представлених векторним простором вирішальною функцією на основі повороту координат з наступним відображенням однієї з координатних осей. У реальному виробництві такий підхід дозволяє на спрощених базах прецедентів малого об’єму з вибором наявності параметру «так/ні» на основі однакової математичної моделі та постановки оптимізаційних завдань проводити не тільки дослідження впливу окремих виробничих факторів на якість та довговічність виробу у рамках його загального життєвого циклу, але й отримати дані, на основі яких можуть бути визначені загальні рекомендації через зміну прояву ознак відносно цільової функції. Це дозволить, окрім фактичної діагностики існуючого виробництва, проводити дослідження майбутнього виробництва, а також аналізувати стратегії розвитку як окремих етапів, так і їх сукупності.

Методика визначення значення параметрів розділової функції дозволяють прогнозувати ступінь впливу кожної складової вектора на кінцевий результат та представлення загального образу. Запропоновані системи рівнянь для вирішення задачі «виключаюче «або»» на основі повороту координат з наступним відображенням однієї з координатних осей та застосуванням цільової функції дозволяють виконувати багатокритеріальне дослідження стратегії, які дозволять отримати результат з бажаним ефектом.

Отримані дані дають можливість застосовувати метод визначення системи координат векторного простору, який розділяє результати за мінімумом цільової функції. На основі цього проводиться визначення впливу факторів процесів виробництва на етапах виготовлення на кінцевий результат. Такий підхід дає можливість обґрунтовувати проектування інноваційних технологій, які б забезпечували оптимізацію життєвих циклів виробів машинобудівного виробництва.
Synthesis and Atimicrobial Evaluation of Deuterated Analogues of Metronidazole
Authors: Anjana G V
Published: December 2022

The discovery of novel therapeutic molecules is always difficult, and there are a variety of methodologies that use the most diverse and innovative medicinal chemistry approaches. One such approach is the deuteration technique: Deuteration is the process of substituting deuterium for hydrogen in a molecule. When compared to the drug molecule, its deuterated analogues may retain the features of the original molecule and, in some cases, improve its pharmacological activity, with fewer side effects and lower toxicity. Metronidazole is a commonly used antibiotic to treat anaerobic bacterial infections, protozoal and microaerophilic bacterial infections. Metronidazole has a half-life of 6.5 ± 2.9 hours. A number of studies have recently been conducted on the selective substitution of hydrogen with deuterium. which increases the bond strength, increasing the biological half-life and, consequently, the drug's metabolic stability also increases. In an attempt to address metronidazole's drawbacks and clinical resistance, deuterated metronidazole was synthesised, characterised, and tested for antibacterial, antifungal, and anti-tubercular activities. The metronidazole and its deuterated compound showed equipotent antifungal activity and aerobic antibacterial activity. Also, when compared with the non-deuterated compound, deuterated metronidazole exhibited better anaerobic antibacterial and anti-tubercular activity.
A comparison of public disclosure in archives and libraries using TransPa_BA
Authors: Pacios Ana R. , Martínez-Cardama Sara
Published: December 2022

Transparency has drawn considerable international attention as an umbrella term covering issues relating to the struggle against corruption, the design of more open and participatory government and institutional, corporate, and social agent accountability. It is likewise associated with open data and guaranteed access to public information. However, transparency also has a second important dimension, viz. public disclosure, whereby institutions are required to furnish citizens with public information in their interest. Assessment of both dimensions of transparency poses problems and difficulties. The present article discusses the results of applying the TransPa_BA tool to assess public disclosure in 202 archives and libraries (information units) under the aegis of different government bodies. This tool proposes a series of indicators to measure active disclosure by public libraries and archives in keeping with the provisions of Spanish Act 19/2013 of 9 December on Transparency, Access to Public Information and Good Governance. The indicators and their respective parameters (content, form, reusability, accessibility, dating and updating/validity) establish general outlines enabling these institutions to enhance their transparency by furnishing not only society in general, but also their stakeholders, with information regarding their activities and performance. Accessibility of active public disclosure-related documents was found to be wanting in all but university libraries. As a collective learning tool for information unit managers, TransPa_BA can be used to monitor and gradually improve transparency in libraries and archives.
Trajectories and regimes in research versus knowledge evaluations: Contributions to an evolutionary theory of citation
Authors: Leydesdorff Loet , Zhang Lin , Wouters Paul
Published: December 2022

Citation analysis can provide us with models of the evolutionary dynamics in scholarly and scientific communication. We propose to distinguish between institutional research evaluation (usually, ex post) and knowledge evaluation ex ante, in relation to directionality in citation analysis. We discuss the theoretical literature on communication systems which distinguishes between information and meaning, in which the concept of redundancy plays an important role as measure of the potential of a communication system. This is the basis for a model of knowledge dynamics which differentiates between observable variation and latent selection environments. We use indicators at the journal level and analyze the citation environments of journals in both the cited and citing directions. Among journals, the citing direction can be analyzed by co-citation and indicates the integration of knowledge from different fields. The cited direction can analogously be analyzed by bibliographic coupling and represents the extent to which the cited journal has become relevant for different disciplines, hence indicates knowledge diffusion. We apply this analysis on three different case studies of journal-journal relations: a small scale study of the journal Public Understanding of Science, a random sample of 100 journals, and a large-scale analysis of the set of JCR 2016 journals. Combined, the results seem to confirm the hypothesis that interdisciplinarity cannot be captured by one-dimensional citation analysis. Both citing and cited directions are relevant for knowledge and research evaluations, respectively. We raise the question whether indicators of interdisciplinarity can be developed by combining both directions in citation analysis, indicate further research, and discuss the normative implications of our preliminary results.
Transparency mechanisms in the media: analysis of Spain and Portugal
Authors: Renedo-Farpón Cristina , João Canavilhas João x , Díez-Garrido María
Published: December 2022

Transparency in the media has become a fundamental pillar within all democratic societies, as a mechanism for reinforcing government regulation (Anderson, 2009) and citizen trust in institutions (Vos and Craft, 2016). Journalism, which has traditionally acted as a watchdog and a check on power, is now in the midst of a credibility crisis, compounded by polarization and the rise of disinformation. For this reason, various studies advocate that media outlets, just like institutions and governments, should use transparency mechanisms that allow them to respond directly or indirectly to society regarding the content they publish, as an exercise of responsibility. This research aims to evaluate media transparency in the Spanish–Portuguese landscape by means of an index that includes variables studied in the theoretical framework and that come from legislative, academic, and professional sources. These variables have been used to measure corporate and financial transparency, transparency in content production, openness to public participation, and the self-regulation mechanisms of ten media outlets in Spain and Portugal. This study concluded that, with only 43% adherence to the transparency variables analyzed, promoting accountability is still a work in progress for media outlets, and it must be stepped up at both the academic and professional levels.
Women in the documentary industry: Continuing inequality in the streaming age
Authors: Izquierdo-Castillo Jessica , Torres-Romay Emma
Published: December 2022

Assessing women’s role in the audiovisual industry provides us with negative data regarding the number of women in the industry, which are also confirmed when factors such as their prominence or leadership in these audiovisual projects are considered. A quantitative and qualitative analysis was thus undertaken based on the need to examine this problem in depth to determine what is happening in the documentary or nonfiction genre, which has exhibited significant growth thanks to the demand for content from subscription video-on-demand (SVoD) streaming platforms. This research analyzes data on the number, prominence, and leadership of women through a review of the 35 Spanish productions in this genre that were produced and/or distributed exclusively on the three leading platforms in Spain between 2016 and 2021. Accordingly, the 2,099 jobs created by these productions have been evaluated, providing data on the occupations and level of responsibility that women had. The research findings confirm the overall data. In addition, they allow us to determine why, although the documentary genre has been associated with greater opportunities for women, this has not held true within the streaming market, where this genre has achieved a greater impact. This underrepresentation of women is especially prominent in the area of leadership.
İnsan Kontrolü Dışındaki Köpekler için Kullanılan Kavramların Karmaşıklığı
Authors: KETEN Akif
Published: December 2022

Köpekler ilk evcilleştirilen hayvanlar olup, insanoğlu tarafından başlangıçta avcılık amacıyla kullanılmıştır.Günümüzde ise çok farklı amaçlar için beslenmektedir. Ancak çeşitli nedenlerle insandan bağımsızlaşan köpeklerşehirler başta olmak üzere farklı habitatlarda hayatlarını sürdürmekte ve kontrolsüz şekilde üreyebilmektedir. Bu bazısorunları da ortaya çıkarmıştır. Son zamanlarda ilgi grupları arasında farklı konularda tartışmalara kadar giden anlayışlarbulunmaktadır. Köpeklere toplumun ilgisi köpekler için kullanılan kavramsal çeşitliliğe ve karmaşaya da sebepolmaktadır. Kontrol dışındaki köpekler için kullanılan adlandırmalarla ilgili farklılıkları ortaya koymak için bu çalışmayapılmıştır. İnternet arama motorları yardımıyla yapılan çalışmada baskın olarak “Sokak” kelimesiyle (%86)adlandırmalar yapılmaktadır. En yaygın kullanımlar “Sokak hayvanları”, “Sokak köpeği”, “Sokak köpekleri”, “Başıboşköpek”, “Sokak hayvanı”dır. Resmi yazışmalarda ise “Sahipsiz” kelimesiyle kullanılmaktadır. Bu hayvanların her yaşamortamında varlıklarının bilinmesinden dolayı isminin sokaklarla özdeşleştirilmesi doğru olmayacaktır. Serbest biçimdefarklı yaşam ortamlarında bulunan evcil hayvanlara “Sahipisiz” denilmesi önerilmiştir.
Examination of disadvantaged children's communication skills with sports branches
Authors: GÜVEN Faruk , YILGIN Ahmet , ŞAHİN Hacı Murat
Published: December 2022

In this study, it was aimed to examine the development of communication skills in the sports education project of Turkish and Syrian refugee students aged 9-15, who were considered disadvantaged with the "Young Together" project of the Ministry of Youth and Sports. In the study, the disadvantaged children living in the province of Kilis form the universe, while the students included in the project form the sample. In the study, the changes in the emotional and behavioral communication of the participants, which are included in the communication skills, were evaluated by giving training to the students in 5 different sports branches for 16 weeks, 2 days and 4 hours a week. In the study, the description was made in the scanning model, which is one of the quantitative research methods. In the study, the data obtained from 109 people determined by random method among 320 individuals who participated in the project voluntarily were evaluated. A questionnaire consisting of demographic information and communication skills inventory was used in the measurement tool of the study. In the analysis of the data, demographic variables were processed using the JASP statistical program, percentage and frequency, and other analyzes were processed with t-test, one-way analysis of variance and correlation tests at p
Age effect on mesenchymal stem cell properties: a concise review
Authors:   Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, Guangdong, China, Chen Chong-Bo , Bin Xin , Huang Yuqiang , Kin Ng Tsz , S. Cheung Herman
Published: December 2022

Mesenchymal stem cells belong to one of the multipotent stem cell types isolated from almost all tissues in the human body. They function to maintain tissue homeostasis with their highly proliferative property, and they also possess immunomodulatory properties. The properties of mesenchymal stem cells can be influenced by multiple factors, among which donor ages have been indicated negatively correlated with the proliferation, migration, and differentiation of mesenchymal stem cells. Telomerase activity, telomere length, and cell senescence have been studied to understand the mechanisms of the age effect on mesenchymal stem cell properties. Rejuvenation treatments are the critical research direction to attenuate the deterioration of mesenchymal stem cell properties by the age effect. This review article summarized the updated research on the impact and mechanisms of aging and age-related factors on different mesenchymal stem cell properties. In addition, the treatments to rejuvenate the aged mesenchymal stem cells will also be discussed. This review article aims to enlighten scientific researchers in better preparing and nursing the autologous mesenchymal stem cells from the elderly for future applications in tissue engineering and regenerative medicine. Keywords: Mesenchymal stem cells, aging, proliferation, migration, differentiation
Possible scenarios of the development of antibiotic resistance in patients with urinary tract infection after the COVID-19 pandemic era
Authors:   Central District Hospital, Outpatient Department, Kamenolomni, Rostov Region 346480, Russia., V. Krakhotkin Denis , A. Chernylovskyi Volodymyr , Greco Francesco , M. Halilov Shuhrat
Published: December 2022

An outbreak of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), the causative pathogen for COVID-19 was reported at the end of December 2019 in Wuhan, Hubei province, China, and by March 2020, it was declared a pandemic COVID-19. In hospital and critical care department settings, the majority of patients with COVID-19 receive broad-spectrum antibiotics for treatment of secondary infection complications. In patients affected by COVID-19, who had a suspected secondary bacterial superinfection, antibiotics including teicoplanin, clarithromycin, doxycycline, azithromycin, tetracyclines, levofloxacin, moxifloxacin, ciprofloxacin, and cephalosporins 3d generation were proposed as an effective treatment. In this editorial, we will consider possible scenarios of the development of antibiotic resistance after the pandemic COVID-19 in patients with urinary tract infection (UTI).
Land reform in Ukraine
Authors:   Mykolayiv National Agrarian University, Krylova Irina
Published: December 2022

Abstract. Introduction. Land reform is a set of measures aimed at solving complex issues of land relations regulation based on rational, efficient and sustainable land use. It guarantees citizens and local communities the right to own land, the formation of a transparent mechanism for the distribution and circulation of land resources, as well as an effective system of state management of land use. Purpose. The aim of the article is to analyze the relevance of the new land reform of Ukraine, the basic requirements for the sale and purchase of agricultural land, study the structure of the land fund of Ukraine, composition and structure of agricultural land, distribution of crops by ownership, analytical assessment of expected results from law enforcement. Results. Since the introduction of land reform in Ukraine, many problematic factors have been identified that slow down the process of concluding agreements for the purchase and sale of agricultural land. In particular, the following problems of land sales were identified: long-term verification of documents, imperfect legislation, refusal of notaries to enter into sales agreements, lack of supply in the land market, shortcomings of credit schemes for land purchase, high cost of credit. Conclusions. As a result of the analysis of land reform in Ukraine, it can be noted that the reform opens new opportunities for landowners, farmers, communities and all Ukrainians who previously did not have the opportunity to acquire and dispose of land. The population is free to dispose of its property, as befits the full owners of a democracy. The reform contributes to the economic development of the regions and the country as a whole
Features of Investment and Innovation Management in Agriculture of Ukraine
Authors:   Uman National University of Horticulture, Movchaniuk Anastasiia
Published: December 2022

Abstract. Introduction. Successful functioning of the agricultural enterprise in modern conditions of fast change of needs of consumers and aggravation of competition is impossible without creation effective measures for improvement of qualitative indicators of production, modernization and expansion of manufacture, development of new directions and spheres of activity and also need to plan investment and innovation activities at the enterprise. After all, the chosen innovation and investment strategy is the main tool in achieving economic development and ensuring the competitiveness of entrepreneurial activity, which is why investment and innovation activities need to pay considerable attention to enterprises that operate in market conditions. Purpose. The purpose of the article is to assess investment and innovation activities in agriculture, identify existing problems in this area of the economy and justify ways to intensify investment processes in agricultural production. Results. The experience of many countries with market economies shows the importance of expanding investment support, innovation of economic structures. At present, Ukraine needs to pay more attention to the creation and implementation of promising investment programs to support the innovative development of all sectors of the economy. This will allow the country to increase the competitiveness of its own production and expand the list of technological opportunities in agriculture. In order to increase the efficiency of management at agricultural enterprises and revive the industry, it is necessary to promote the attraction of domestic and foreign investments in the development of agriculture and agro-industrial complex of the country. Conclusions. In determining the innovation and investment strategy for the development of agricultural enterprises in the near future should focus on ensuring and maintaining existing production capacity, creating innovation and investment projects that quickly recoup the investment in production processes, while ensuring the production of competitive products. The key to the implementation of investment activities of agricultural enterprises is also: completion of agricultural land reform aimed at forming a transparent circulation of agricultural land, providing state guarantees of protection to potential investors in agribusiness and socio-economic projects within the revival and development of rural areas.
Worldwide predictors of violence in acute health care settings and recommendations for action
Authors: Shaaban Khalil Nahla
Published: December 2022

Healthcare workers are exposed to various violent behaviors, such as physical violence, threats, and psychological violence at their work. The experience of workplace violence is associated with various serious health outcomes including depression, loss of self-esteem, sleep disorders, anxiety, and Lack of concentration. Therefore, this editorial is conducted to stress the worldwide predictores of violence in acute health care settings and recommendations for action
Protein A Chromatography Purification for a Monoclonal Antibody from Process Development to Scale-up
Authors:   Auctores Publishing LLC, Bas Dilara , Burak Erkal Emre , Korkmaz Melis , Recepoglu Ali , Elitas Hazal , Baycin Demirhan Deniz
Published: December 2022

Monoclonal antibodies have been established as a major product class of biotechnology-based drugs. The increasing demand of monoclonal antibodies has led pharmaceutical companies to adopt efficient production processes. Transferring monoclonal antibody production to the industrial manufacturing requires adequate effort in process development. The strategy to reduce development time and cost comprises high-throughput process development which is especially central for the rapid optimization of the purification process. Chromatography process is the backbone of the purification process that can deliver high purity but it requires significant resources. Combined with high-throughput process development approach, the chromatography process is easy to develop and scale-up from laboratory to manufacturing scale. Design of experiments helps high-throughput process development workflow to provide decision-support techniques. This approach ensures significantly decreased time and material needs while improving the chromatography process. Protein A affinity chromatography is one of the most important chromatographic steps because of its great performance and capabilities. Most of the working parameters can be predefined and are identical for several monoclonal antibodies. However, some parameters like elution pH, loading capacity, resin type need further optimization for each monoclonal antibody. In this study, the loading and elution parameters were screened for Protein A chromatography to identify the best purification conditions using the combination of Design of Experiments and high-throughput process development approach in micro-volume columns. Developed working parameters were used for scale-up and tested under robust process conditions. Specific chromatography conditions were applied in pilot-scale and data comparison was done with micro-volume columns, lab-column scale to validate high-throughput strategy approach