bluuebunny/crossref_metadata_2025 huggingface dataset:
D3PM: A Comprehensive Database for Protein Motions Ranging from Residue to Domain
Authors: Peng Cheng , Zhang Xinben , Xu Zhijian , Chen Zhaoqiang , Yang Yanqing , Cai Tingting , Zhu Weiliang
Published: September 2020

Background: Knowledge of protein motions is significant to understand its functions. The currently available databases for protein motions, in general, are focused on overall domain motions, which pay little attention to local residue motions. Albeit with relatively small scale, the local residue motions may play crucial roles in protein functions and its binding with ligand, in particular for those residues within binding pockets. Results: A comprehensive protein motion database (D3PM) was constructed in this study to facilitate the analysis of protein motions. The D3PM has the motion information ranging from the overall structural changes of macromolecule to the local flip motion of the residues in ligand binding site. Currently, the D3PM has 5,339 entries of overall motions and 2,319 entries of pocket residues’ motions. The motion patterns in the database are classified into 4 types of overall structural change and 5 types of pocket residues’ shift. Impressively, it was found that less than 15% of the protein pairs have obvious overall conformational adaptations induced by ligand binding, while more than 50% of the protein pairs have significant structural changes in the ligand binding sites, indicating that ligand-induced conformational changes are drastic whereas they are mostly confined around the ligand. By the analysis of pocket residues’ preference, we classified amino acids into “pocketphilic” and “pocketphobic” residues, which is helpful to pocket prediction and ligand design.Conclusion: D3PM is a comprehenssive database about protein motions ranging from residue to domain, which should be useful for exploring diverse protein motions and for understanding protein functions. The database is freely available on www.d3pharma.com/D3PM/index.php.
Effectiveness of dietetic intervention for people with type 2 diabetes: a meta-analysis
Authors: Siopis George , AO Stephen Colagiuri , Allman-Farinelli Margaret
Published: September 2020

Background
Diet is central to treatment of type 2 diabetes. This review aimed to compare the effectiveness of nutrition therapy delivered by dietitians to nutrition advice delivered by other healthcare professionals in adults with type 2 diabetes on metabolic parameters.
Methods
Cochrane CENTRAL, CINAHL, EMBASE, MEDLINE and PsychINFO were searched for randomised controlled trials of three months duration or longer, published from 1st January 2008 to 18th June 2019. Relevant data were extracted from studies with additional author information. Random-effects meta-analysis assessed mean changes in HbA1c and other clinical parameters. PROSPERO registration number: CRD42019130528.
Results
Of 2477 records identified, fourteen studies (n = 3338) were eligible for qualitative synthesis and meta-analysis. The mean changes [95% CI] at follow-up in HbA1c, BMI, weight, LDL cholesterol, systolic and diastolic blood pressure were − 0·47 [-0·92, -0·02] %, -0·38 [-0·63, -0·13] kg/m2, -1·49 [-2·14, -0·84] kg, -0·15 [-0·33, 0·04] mmol/L, -0·75 [-2·45, 0·96] mm Hg and − 1·17 [-4·52, 2·17] mm Hg respectively in favour of the intervention group.
Conclusions
Nutrition therapy provided by dietitians was associated with better clinical parameters of type 2 diabetes, including clinically significant improved glycaemic control, across diverse multiethnic patient groups from all six inhabited continents. This conclusion should be reflected in clinical guidelines.
Comparison of Whole-Genome Sequences for Three Species of the Elizabethkingia Genus
Authors: Yang Chen , Liu Zhe , Yu Shuai , Ye Kun , Li Xin , Shen Dingxia
Published: September 2020

Background: There are increasing researches on whole-genome sequences for clinical strains of Elizabethkingia genus which can cause severe infection in humans, while few studies on the comparative genomics of species in the Elizabethkingia genus in China have been conducted. Methods: The Elizabethkingia genus, isolated in a tertiary hospital of Beijing, China, were re-identified and analyzed through in silico DNA-DNA hybridization (DDH), whole-genome sequence-based phylogeny. Antibiotic resistance genes, antimicrobial resistance-associated proteins, virulence factors were identified, and clusters of orthologous groups were evaluated by Kyoto Encyclopedia of Genes and Genomes (KEGG). The clinical information of patients infected by these organisms was collected and the characteristics were analyzed. Results: There were three species among 20 clinical isolates of Elizabethkingia genus: E. meningoseptica, E. anophelis and E. miricola. E. anophelis accounted for the majority. E. meningoseptica exhibited higher GC content and possessed carbapenemase-encoding genes of blaGOB-16 and blaB-12 while E. anophelis carried genes of blaCME-1. Multiple kinds of antimicrobial resistance-associated proteins were predicted and the virulence factors about adherence, biofilm formation, iron and magnesium uptake, stress adaptation, and immune evasion were discovered. Among 2622 clusters of core genomes identified from the three species of the Elizabethkingia genus, the majority of genes were metabolism-related. Pan genome displayed an upregulation, while the core genome displayed a downregulation with the addition of new genes for the 20 Elizabethkingia strains. Conclusions: The composition was different in antimicrobial resistance-related, virulence-related and metabolism-related genes depending upon species of Elizabethkingia. An adaptive evolution of Elizabethkingia to environmental change including hospital settings has been developed.
Determination of Carcinogenic Toluena Detox Mass In Printing Industrial Workers In Surabaya
Authors: Novianti Rista , tualeka abdul rohim , Guan Ng Yee
Published: September 2020

Background

This study aims to calculate the intake of foods rich in CYP2E1 enzymes and glutathione to increase toluene detoxification.
Methods

The research design used was a cross sectional method. The research location is printing industry in Surabaya, East Java. The number of respondents was 30 workers of the printing industry. The calculated variables included body weight, work duration (years), work frequency per week (days), average workday (hours) of the respondent and benzene concentration. After all variables were obtained, respiration rate and carcinogenic detox benzene food intake per respondent were determined.
Results

All respondents who were at work showed benzene concentrations below the threshold value (TLV). Foods containing CYP2E1 enzyme included beef liver, salmon and fish oil while food with glutathione included grapes, avocados and asparagus.
Conclusion

Adequacy levels of CYP2E1 enzymes and glutathione are different and varied. The effective dose required by each respondent depends on body weight, length of work, and toluene concentration at work. In sum, the greater the toluene concentration, the greater the dietary needs which are rich in enzymes and CYP2E1 glutathione. Each respondent can choose benzene detox food depending on their needs and appetite.
Synergistic Effects of Adding A Substrate and an Organic Reductant for Stimulating the Bioremediation of 4-Chloronitrobenzene-Contaminated Soil
Authors: Li Tian , Zhang Ping , Zhang Tian C
Published: September 2020

Background: Soil contaminated with 4-chloronitrobenzene (4NCB) is resistant to microbial degradation due to the electron-withdrawing properties of the nitro and chloro groups in 4NCB. Currently, sufficient information is not available on how to use biostimulation strategies to enhance the bioremediation of 4NCB-contaminated soil.Results: In the present study, a novel strategy was developed by utilizing the synergistic effects of adding an organic reductant (ascorbic acid, VC) and an organic nitrogen source (peptone) to stimulate the biodegradation of 4NCB-contaminated soil. Using this strategy, the bioremediation of 1 g-4NCB/ kg-1 soil could be completed within 8 days in soil batch reactors. Furthermore, the study discovered two 4NCB cometabolic intermediates in the soil reactors added with peptone and VC, and for the first time, 4NCB was transformed to 4-chlorofromanilide.Conclusion: The proposed strategy is promising because it is highly efficient, easy to control and involves a non-toxic, environmentally friendly substrate/reductant.). Finally, this approach warrants future studies to extend its applications to soils contaminated with other nitroaromatic compounds.
Examining the Effect of Education on Dietary Calcium Intake in Reducing Blood Pressure Variability Among Pregnant Mothers in Tigray Region, Northern Ethiopia, Two Arm, Randomized Control Trail Parallel Design
Authors: Abrha Mulugeta Woldu , Abarha Alemnesh , Gebretsadik Ataklty , Ayele Brhane , Gebretensae Haylay , Gebre-egziabher Equbay , Hadgu Tsegay , Mulugeta Afework
Published: September 2020

Background: Investigating effects of calcium diets on blood pressure can contribute to development of diet based recommendations for health. Epidemiologic data suggest contradicting evidence relationship between dietary calcium intake and pregnancy-induced hypertension. So, this study aimed to determine the effect of calcium nutrition education on blood pressure variability among pregnant mother.Method: Single center, two-arm, main individual randomized trial parallel design; single blinded was conducted among 415 pregnant mothers. Bi-variable tabulations were computed to identify the distributions of the outcome variables by selected background characteristics. We estimated a multilevel model that assessed the relation of individual and community level factors (fixed effects) as well as community level random effects. All analysis was conducted using STATA 14 software.Result: Blood pressure variability during pregnancy after 28 gestational age was significantly associated with weekly calcium nutrition education [AOR=0.38; 95% CI: 0.19, 0.5], pregnant mothers who attained secondary school [AOR=0.21, 95%CI: 0.20, 0.70], employed pregnant women [AOR=9.05; 95% CI: 1.95, 14.02] , Antenatal Care [AOR=1.82; 95% CI: 1.01, 2.22], supplemented iron/folic acid [AOR=6.32; 95% CI: 1.09, 36.59], food craving [AOR=0.78; 95% CI: 0.20, 0.98], reading newspaper [AOR=9.05; 95% CI: 1.95, 14.02], place of residence [AOR=2.11; 95% CI: 1.36, 3.26]. Conclusion: Individual level factors (Calcium nutrition education, maternal educational status, maternal occupation, Antenatal care during last pregnancy and current pregnancy, iron/folic acid supplementation, food craving, dietary calcium level and reading newspaper) and community level factors (place of residence) were significant predictors of blood pressure variability. During antenatal visits, pregnant women should be made aware of some dietary practices which are harmful during pregnancy, and increase education regarding the benefit of adequate nutrition. Trail Registration: PACTR, PACTR202009693949631 and Registered 02 September 2020- Retrospectively registered
Stroke Leads to Abnormal Coordination of the Multiple Upper Extremity Joints During Passive Movement
Authors: Koh Kyung , Kim Dongwon , Oppizzi Giovanni , Zhang Chunyang , Kehs Glenn , Zhang Li-Qun
Published: September 2020

Background Motor impairments in the upper extremity (UE) is one of the most common deficits after stroke. Even though understanding of UE coordination deficits in persons with strokes is critical for better identification of motor impairment and planning for rehabilitation, it is still not clear how stroke affects coordination patterns of multi-joint movements in the UE. Here, we investigated kinematic and kinetic coordination patterns of UE after stroke during controlled passive arm movement. Methods An exoskeleton multi-joint robot moved the participant’s arm in the horizontal plane back and forth in 8 repetitions, in inward movement (i.e. toward the body) and outward movement (i.e. away from the body). The uncontrolled manifold analysis (UCM) was used to quantify kinematic and kinetic coordination patterns of the UE. Variability of joint angles and torques were decomposed into task-relevant variability (TRV) and task-irrelevant variability (TIV). An index of coordination (IC) was defined based on TRV and TIV. Results We found that the IC of joint torques in the stroke group significantly decreased during outward movement in comparison to that during inward movement, while IC of the control group showed no difference between the two movement directions. The decreased IC in the stroke group during outward movement was mainly due to the increased TRV of joint torques. In the further analysis of individual joint level, during outward movement, stroke group had a greater TRV of joint torques at all joints while during inward movement, stroke group had a lower TRV of joint torques at elbow joint. Conclusions Our results indicate that the stroke can cause the kinetic coordination deficits induced during a passive movement especially in outward movement. Our findings suggest that it is important to consider the passive kinetic coordination deficits to enhance post-stroke rehabilitation interventions. Trial registration clinicaltrials.gov, ID: NCT02359812. Registered 23 January 2015; Last Updated 06 August 2020.
Novel insights into the mechanisms by which lncRNAHOTAIR regulates migration and invasion in HeLa cells
Authors: zheng peng , Liu Zi cheng Lin , Hu Fan , Chen Ying , Chen Zhuo , Zhang Cun Tong
Published: September 2020

Background

HOTAIR, as one of the few well-studied oncogenic lncRNAs, is involved in human tumorigenesis and is dysregulated in most human cancers. The transcription co-activator factor YAP1 is broadly expressed in many tissues, and promotes cancer metastasis and progression. However, the precise biological roles of HOTAIR and YAP1 in cancer cells remain unclear.
Methods

The expression levels of HOTAIR and YAP1 were measured by quantitative PCR (qPCR), immunoblotting. Wound-healing and transwell assays were used to examine the invasive abilities of HeLa cells. Luciferase reporter assays and CHIP were used to determine how YAP1 regulates RPL23. A xenograft mouse mode was used to assess the correlation between HOTAIR and YAP1 in vivo.
Result

In this study, we showed that HOTAIR regulates H3K27 histone modification in the promoter of miR-200a to mediate miR-200a expression byrecruiting EZH2. YAP1, as a potential target gene of miR-200a, aggravated the effects of miR-200a on the migration and invasion of HeLa cells. YAP1 activated the transcription of RPL23, which is a novel target of YAP1 transcriptional regulation. Agreement with this, the expression of YAP1 and RPL23 was dramatically decreased after injecting HeLa cells transfected with siHOTAIR in a xenograft mouse model.
Conclusion

These elucidates that HOTAIR, as an oncogenic lncRNA, recruits EZH2 to reduce miR-200a-3p expression via H3k27 trimethylation in the miR-200a-3p promoter. As a target gene of miR-200a-3p,YAP1 then promotes the migration and invasion of HeLa cells by mediating the downstream transcription of RPL23 which normally functions as a cancer-promoting factor. Accordingly, we propose a novel model of the molecular mechanism by which HOTAIR promotes the migration and invasion of cancer cells involving the miR-200a-3p/YAP1/RPL23 axis.
The Protective Impact of Education on Brain Structure and Function in Alzheimer’s Disease
Authors: Zhu Wanqiu , Li Xiaoshu , Li Xiaohu , Wang Haibao , Li Meiqin , Gao Ziwen , Wu Xingqi , Tian Yanghua , Zhou Shanshan , Wang Kai , Yu Yongqiang
Published: September 2020

Background: The Cognitive Reserve (CR) theory posits that brains with higher reserve can cope with more cerebral damage to minimize clinical manifestations. The aim of this study was to examine the effect of education (CR proxy) on brain structure and function in Alzheimer’s disease (AD) and amnestic mild cognitive impairment (aMCI) patients and in cognitively healthy elderly (HC) individuals.Methods: Fifty-seven AD patients, 57 aMCI patients and 48 HCs were included to investigate the relationships between education years and gray matter volume (GMV), regional homogeneity (ReHo) and functional connectivity (FC) in brain regions to show associations with both structure and function. Taking the severity of the disease into account, we further assessed the relationships in AD stratified analyses. We then compared more highly (higher CR) and less highly educated (lower CR) subjects at the same level of cognitive impairment. Results: In AD group, the GMV of the dorsal anterior cingulate cortex (dACC) and ReHo in the left inferior temporal cortex (ITC) were inversely associated with education years, after adjustment for age, sex, Mini-Mental State Examination (MMSE), and total intracranial volume or head motion parameters. Seed-based FC analyses revealed that education years were negatively correlated with the FC between the left anterior ITC and left mid frontal cortex as well as right superior frontal cortex and right angular gyrus. Stratified analyses results indicated that this negative relation between education and GMV, ReHo, FC was mainly present in mild AD, which was attenuated in moderate AD and aMCI groups. In mild and moderate AD groups, subjects with higher CR had smaller regional GMV of the dACC and lower ReHo in the left ITC than the subjects with lower CR. No significant differences were found in severe AD and aMCI groups.Conclusions: Our results support the CR theory, and suggest that CR may be protective against AD related brain pathology at the early stage of clinical dementia. These findings could provide the locus of CR-related functional brain mechanisms and a specific time-window for therapeutic interventions to help AD patients to cope better with the brain pathological damage by increasing CR.
Wnt5b-induced PCP/JNK Activation Promotes PD-L1 Expression and the Malignant Phenotype of Non-small Cell Lung Cancer 
Authors: Wu Guangping , Luo Yuan , Xie Yusai , Han Yang , Zhang Di , Han Qiang , Zhao Xinran , Qin Ye , Li Qingchang , Wang Enhua , Zhao Huanyu
Published: September 2020

Background: Wnt5b is noncanonical Wnt ligand, and programmed-death ligand 1 (PD-L1) is a targeted agent for immunotherapy, but the mechanism by which Wnt5b regulates PD-L1 expression in non-small cell lung cancer (NSCLC) is unclear. Methods: Wnt5b and PD-L1 expressions were detected in NSCLC specimens by immunohistochemistry. The interrelationship connecting Wnt5b with PD-L1 was verified using dual-luciferase assay, immunofluorescence, coimmunoprecipitation, western blot，real-time PCR and xenograft tumor model. Results: Wnt5b and PD-L1 expressions were positively correlated in NSCLC specimens. Five-year survival time in the group with their coexpression was significantly lower than that without coexpression. Under the effect of Wnt5b, Frizzled-3 (Fzd3) initiated Dishevellde-3 (Dvl-3) membrane recruitment via DEP domain by Dvl-3 phosphorylation, contributing to activate PCP/JNK signaling through the small GTPase Rac1, and then upregulate PD-L1 expression and promote the malignant phenotype of NSCLC in vivo and in vitro. After PD-L1 antibody treatment, Wnt5b induced tumor growth was inhibited significantly in xenograft tumor model. Conclusion: We demonstrate a new signal transduction pathway: Wnt5b initiates Dvl-3 membrane recruitment via DEP domain by Fzd3 so as to promote Rac1–PCP/JNK–PD-L1 pathway, which provides a potential target for clinical intervention and immunotherapy in lung cancer.
Post-Abortion Family Planning Utilization and Associated Factors Among Women Seeking Abortion Service: Cross-Sectional Study
Authors: Woldemichael Dereje , Agaro Gabi , Jima Aman , Woldemichael Bedasa
Published: September 2020

Background - Ethiopia is one of the countries which suffer with highest unintended pregnancies and unsafe abortion. The aim of this study was to assess the utilization of post-abortion family planning and associated factors among women seeking abortion service in Asella town health facilities 2019.Methods: A facility based cross-sectional study design was conducted among women who came for abortion service from July 15 to October 15, 2019. Two hundred seventy-six participants were included using systematic random sampling technique. Both descriptive and logistic regression analysis were conducted. In multivariate analysis, variables which had p-value < 0.05 was considered as significantly associated with the outcome variable. Results: Postabortion family planning utilization among study participants was 146 (53.7%) (95% CI=47.4, 59.2). Formal education (AOR=4.45: 95% CI: (1.18, 16.74) , previous history of abortion (AOR=0.35; 95% CI: (0.14, 0.85), positive attitude (AOR=2.62; 95% CI: (1.09, 6.27), counseled on post abortion family planning utilization (AOR=3.12; 95% CI: (1.30, 7.51) were significantly associated with post abortion family planning utilization.Conclusions: In this study, nearly fifty percent of the respondents did not utilize Postabortion Family Planning (PAFP). Educational status, history of pervious abortion, decision when to have a child, attitude toward PAFP utilization and counseling about PAFP were significantly associated with post-abortion family planning use. The health care providers who give abortion service should give counseling for all women who get abortion service. More accents should be given to misperception of PAFP to change the negative attitude of utilization of PAFP.
CFD Investigation of Fluid Flow Over Aerofoil With and Without Dimple
Authors: Sajjad Uzair , Hamid Khalid , Abbas Naseem
Published: September 2020

This work labels the effect of dimples on aerodynamic performance of an airfoil. NACA 0018 having a uniform cross section has been evaluated in this study. Eclipse dimpled airfoil is tested and compared with plain airfoil and with the airfoil in the literature [23,24]. Flows taken into consideration are subsonic. The CAD model is drawn in Solid works 2016, while the simulations are performed in Ansys 18.3. A 2-D CFD investigation is performed on both models using k-w turbulence model, subsequently the better one is selected based on the results. 3D analysis is performed on a segment of airfoil having one dimple. Lift and drag coefficients are calculated for various angles of attack. This investigation tells that dimples affect the aerodynamics of airfoil, particularly for various angle of attacks. For smaller angle of attacks, plain airfoil showed less drag and higher lift, but totally different trend is achieved with increasing angle of attack whereas 20° was found to be the optimum angle. The findings proved that dimples on the surface delay the separation of boundary layer by generating additional turbulence on the surface and consequently reduce the formation of wake, which in turn decreases drag significantly.
Effect of Ni2+substitution on the Structural, Magnetic and Dielectric Properties of PbFe12-xNixO19 Nanoparticles
Authors: Ghahfarokhi seyed ebrahim Mousavi , Bazdar Foruzan , Kazeminezhad Iraj , Shobegar Elham Mohammadzadeh
Published: September 2020

PbFe12-xNixO19 nanoparticles (x = 0-1) were prepared by a sol–gel method. The influence of Ni2+ substitution on structural, magnetic and dielectric properties of PbFe12O19 nanoparticles was investigated. The samples of PbFe12-xNixO19 nanoparticles have been characterized by the X-ray diffractomere (XRD), Fourier transform infrared spectrometer (FT-IR), scanning electron spectrometer (SEM), vibrating sample magnetometer (VSM), and an LCR meter. The results reveal that PbFe12-xNixO19 compounds up to x = 0.2 are single phase. The bands of absorption in the 400– 500 cm-1 and the bands of absorption in the range of 500 -600 cm-1, corresponding to the formation of octahedral and tetrahedral sites which confirms the presence of metal– oxygen stretching band in ferrites. Also, SEM images show that by increasing Ni2+ doping grains size have been increased. However, for x > 0.2, the secondary Ni spinel ferrite (NiFe2O4) appears which the saturation magnetization and magnetic coercivity decreases. In addition, Ni2+substitution reduces the dielectric constant, dielectric loss, and ac electrical conductivity for all samples decrease rapidly with increasing applied field frequency and reaches a constant value beyond a certain frequency which this is characteristic of the normal dielectric behaviour of ferrites and has been investigated by Maxwell–Wagner’s two-layer model and Koop’s theory. The variation in ac conductivity (σac) with frequency shows that the electrical conductivity in these ferrites is mainly attributed to the electron hopping mechanism.Therefore; all single-phase Ni2+ substituted samples are suitable for use in magnetic recording media and microwave devices.
Time to and extent of widespread testing for COVID-19 outbreak: Experience from the first wave in Australia and Italy
Authors: Abedin Sumaiya , Khan Atikur , Khan Saleheen
Published: September 2020

Background: At the beginning of COVID-19 outbreak, very little was known about its control options and most of the intervention options relied mainly on other virus outbreak and influenza epidemic. Different countries started responding to this epidemic somewhat in different ways to achieve a common goal of transmission reduction. Population-wide intervention measures such as social distancing, testing and isolation were implemented in different countries. However, commonly adopted intervention measures impacted different countries in different ways. Differential effects of those interventions become apparent in Australia and Italy, where Australia's success to control the epidemic has been in limelight. Differences in time to and extent of widespread testing are likely to have differential effects on the daily number of confirmed cases in both countries.Methods: We apply panel generalized linear models for daily number of cases to explore differential effects of timing to and extent of widespread testing on daily number of cases. We have analyzed daily number of confirmed cases data from the first reported cases in Australia and Italy to 31 May 2020. Our data sets can be downloaded from an open source database at https://ourworldindata.org.Results: More tests during the early stage of outbreak prior to reach the peak may reduce the daily number of cases by almost 40%. Only 1% increase in test positivity on the (t-5)th day may incur 1.84% increase in daily number of cases on the t-th day. For 1% increase in test positivity rate on the (t-5)th day, a country with one unit higher logarithm of population density may result in 2.82 times higher number of cases on the t-th day.Conclusion: Conducting widespread testing during the early stage prior to reaching the peak has favored Australia to control the outbreak much faster than Italy. Early adoption of widespread testing with lower degree of test positivity rates flattens the curve faster. Population density has a moderating effect. Even if the test positivity rate is the same, a region with higher population density is likely to experience a peak with higher number of daily confirmed cases.
Higher spin partition functions via the quasinormal mode method in de Sitter quantum gravity
Authors: Martin Victoria , Svesko Andrew
Published: September 2020

In this note we compute the 1-loop partition function of
spin-ss
fields on Euclidean de Sitter space S^{2n+1}S2n+1
using the quasinormal mode method. Instead of computing the quasinormal
mode frequencies from scratch, we use the analytic continuation
prescription L_{\text{AdS}}\to iL_{\text{dS}}LAdS→iLdS,
appearing in the dS/CFT correspondence, and Wick rotate the normal mode
frequencies of fields on thermal \text{AdS}_{2n+1}AdS2n+1
into the quasinormal mode frequencies of fields on de Sitter space. We
compare the quasinormal mode and heat kernel methods of calculating
1-loop determinants, finding exact agreement, and furthermore explicitly
relate these methods via a sum over the conformal dimension. We discuss
how the Wick rotation of normal modes on thermal
\text{AdS}_{2n+1}AdS2n+1
can be generalized to calculating 1-loop partition functions on the
thermal spherical quotients S^{2n+1}/\mathbb{Z}_{p}S2n+1/ℤp.
We further show that the quasinormal mode frequencies encode the group
theoretic structure of the spherical spacetimes in question, analogous
to the analysis made for thermal AdS in [1-3] .
Ways and characteristics of employee motivation in modern conditions
Authors: Gechbaia Badri , Tchilaia Nino , Goletiani Ketevan , Muskudiani Zurab
Published: September 2020

An effective human resource management system is a crucial factor for all organizations and institutions. In the light of modern development, it is obvious that improving the quality of service and gaining public trust is impossible without motivating employees, evaluating their performance, clearly defining duties and building an organizational culture. It should bo noted that Georgian companies lack well-defined human resource management policy. Moreover, in most cases it is limited to administrative procedures and is considered as an operational activity, despite the fact that everyone understands the importance of each employee in achieving organizational success. Among the various ways to achieve organizational goals, one of the most important is to increase employee motivation. Increasing employee productivity depends on proper choice of the form of motivation and its wise use. If a manager meets the expectations of all employees, in this case, employee motivation increases. which means that the level of employee satisfaction is high and the organizational goal will be fully achieved. All of the above and other important issues are researched and scientifically analyzed in this paper.
Inteligência artificial e computação cognitiva em unidades de informação
Authors: Neves Barbara Coelho
Published: September 2020

Este artigo trata da inteligência artificial, com ênfase na computação cognitiva, como uma problemática contemporânea no contexto da cibercultura. Teve como objetivo investigar na literatura científica os principais aspectos da computação cognitiva em unidades de informação. Procurou levantar as perspectivas da computação cognitiva em unidades de informação e mapear como essas unidades têm utilizado (ou podem utilizar) a inteligência artificial em suas atividades e interação com o usuário. A metodologia utilizada se inscreve como pesquisa bibliográfica. Reflete com ênfase, principalmente, em outras leituras a partir do levantamento bibliográfico realizado na base de dados Ebsco e na Brapci, com recorte de 2009 a 2019. Foi realizada uma análise do discurso simples e a categorização dos assuntos dos artigos a partir das abordagens teóricas do ponto de vista da cibercultura. Destaca como resultado as principais definições encontradas na literatura, um case empírico que está sendo desenvolvido pela autoria deste artigo, a abordagem teórica com base na cibercultura, as perspectivas e aplicações dos artigos investigados. Finalmente se considera que a literatura sobre computação cognitiva trata da biblioteca e do bibliotecário no contexto contemporâneo. Os artigos são predominantes estrangeiros, na sua maioria são populistas tecnocráticos, possuem abordagens qualitativas e se referem a computação cognitiva como inteligência artificial.
Memória e instituição
Authors: Souza Catiele Alves de , Morigi Valdir José
Published: September 2020

Estudo exploratório, qualitativo, com técnica de coleta de dados através de análise documental, realizado na cidade de Porto Alegre, RS, durante o segundo semestre do ano de 2019. Analisa as narrativas registradas nos documentos da Associação de ex-alunos do Instituto Estadual de Educação General Flores da Cunha (AExAIE). Busca compreender a memória desta escola, em funcionamento desde o 1869. Através dos registros memoriais das atividades desta Associação de ex-alunos obteve-se acesso a variadas documentações, como cartas, convites, atas de reunião, livros, fotos, objetos e ao informativo periódico da Associação. Com base nesses documentos foram descobertas narrativas acerca da escola entrelaçadas com datas e itens de memória afetiva. Conclui que as ações dos associados auxiliam tanto para a preservação da memória do Instituto Gen.Flores da Cunha (IE) quanto para o fortalecimento das identidades individuais e do grupo, além de ser uma forma de relacionar-se com a cidade exercitando a cidadania.
Direito ao esquecimento e desindexação da informação
Authors: Lima Paulo Ricardo Silva , Ferreira João Rodrigo Santos , Souza Edivanio Duarte de
Published: September 2020

O desenvolvimento tecnológico promoveu o aumento de produção e compartilhamento de conteúdo em plataformas digitais, sendo difícil gerenciar o acesso adequado a informações. O presente artigo tem como objetivo discutir os efeitos do direito ao esquecimento no ambiente digital, considerando o processo de desindexação como estratégia para operacionalizar a efetividade desse direito. Tomando como referências arcabouços teóricos-conceituais acerca da complexidade compósita da informação e de antinomias entre a dignidade da pessoa humana e a liberdade de expressão e o direito à informação, oriundos, respectivamente, da Ciência da Informação e do Direito, analisam-se e discutem-se algumas decisões jurisprudenciais e posicionamentos doutrinários no cenário brasileiro. O direito ao esquecimento está cercado de ambivalências e desafios de ordens normativa, tecnológica e cultural, num compartilhamento de informações em níveis sem precedentes que interferem negativamente na sua efetivação no ambiente digital.
As tecnologias de poder no diagnóstico da pandemia da COVID-19
Authors: Pinto Simã Catarina de Lima
Published: September 2020

Este artigo retoma os conceitos de poder disciplinar e biopoder em Michel Foucault para, então, fazer um diagnóstico do contexto pandêmico causado pela Covid-19. Ao se considerar que mais da metade da população mundial foi orientada ao isolamento social, bem como à alteração de hábitos cotidianos a fim de diminuir a propagação do vírus SARS-CoV-2, é possível perceber em Foucault as medidas da técnica disciplinar e da tecnologia biopolítica, ambas direcionadas à preservação da vida da população. Considera-se que o poder disciplinar e o biopoder funcionam na atual pandemia num contexto inédito, marcado pelo avanço tecnológico.
A potencialidade da imagem fotográfica como mediadora
Authors: Sá Alzira Tude
Published: September 2020

Este artigo discorre sobre as proposições do homem de ultrapassar o que lhe é visível, de apropriar-se da informação por meio da mediação de sujeitos e dispositivos, apontando para questões epistemológicas que nos séculos XX e XXI têm sido levantadas sobre a imagem fotográfica. Traz conceitos e teorias que, no campo da Ciência da Informação, voltadas para a mediação da informação e seus suportes, dentre eles a fotografia, são revistas por força de modalidades e novas práticas de comunicação possibilitadas pelas tecnologias. Aborda aspectos da relação mantida pela fotografia com a cultura, sua função e usos sociais. Apropriando-se do método heurístico, elege como objeto empírico imagens de objetos da casa do escritor Jorge Amado, registradas no livro Rua Alagoinhas 33, Rio Vermelho. As etapas de identificação, numeração e resumo possibilitaram a desmontagem visual das imagens, a criação de grupos temáticos e a sua remontagem verbal, comprovando que as imagens fotográficas, como dispositivo e fonte de informação, podem ser consideradas um elemento de mediação, cuja leitura e interpretação sinalizam para as relações socioculturais construídas pelos sujeitos e viabilizam a criação de novas narrativas.
Robust and Accurate Detection of Mid-level Primitives for 3D Reconstruction in Man-Made Environments
Authors: Wolters Dominik
Published: September 2020

Die Detektion von geometrischen Primitiven wie Punkten, Linien und Bögen ist ein elementarer Verarbeitungsschritt für viele Techniken des maschinellen Sehens wie Bildanalyse,
Mustererkennung und 3D-Szenenrekonstruktion. In dieser Arbeit wird eine Methode vorgestellt, die eine zuverlässige Detektion von geometrischen Primitiven in Bildern ermöglicht.
Der Fokus liegt auf der Anwendung in urbanen Umgebungen, wobei der Prozess nicht darauf beschränkt ist. Die Methode ermöglicht eine robuste und subpixelgenaue Detektion von Punkten,
Linien und Bögen und erstellt einen Graphen, der die topologischen Beziehungen zwischen den detektierten Merkmalen beschreibt. Die Detektionsmethode kann direkt auf verzeichnete
perspektivische Bilder und Fischaugenbilder angewendet werden. Die zusätzliche Erkennung sich wiederholender Strukturen in Bildern gewährleistet die Eindeutigkeit der Merkmale in
ihrer lokalen Umgebung. Das neu entwickelte Verfahren erreicht eine hohe Lokalisierungsgenauigkeit, die dem Stand der Technik entspricht und gleichzeitig robuster gegenüber
Störungen durch Rauschen ist. Darüber hinaus ermöglicht das Verfahren, mehr Details in den Bildern zu extrahieren. Die Detektionsrate ist bei dem neuen Verfahren auf den
realen Datensätzen stets höher als bei dem aktuellen Stand der Technik. Darüber hinaus kann das neue Verfahren zuverlässig zwischen Linien- und Bogensegmenten unterscheiden.
Die durch das neue Verfahren gewonnenen zusätzlichen topologischen Informationen sind weitgehend konsistent über mehrere Bilder einer Szene und können somit eine Unterstützung
für nachfolgende Verarbeitungsschritte wie Matching und Korrespondenzsuche sein. Die Detektionsmethode wird in eine vollständige merkmalsbasierte 3D-Rekonstruktionspipeline
integriert und es wird eine neuartige Rekonstruktionsmethode vorgestellt, die die topologischen Beziehungen der Merkmale nutzt, um ein abstraktes, aber zugleich semantisch
reichhaltiges 3D-Modell der rekonstruierten Szenen zu erstellen, in dem komplexere geometrische Strukturen leicht detektiert werden können.
Mean Reversion-orientiertes Swing Trading
Authors: Grossmann Vasco
Published: September 2020

In dieser Dissertation wird ein Handelssystem beschrieben und evaluiert, welches rückläufige Tendenzen nach Überreaktionen in Finanzmärkten analysiert und ausnutzt.
Hierfür werden Fehlbewertungen über ein neues Verfahren stochastisch modelliert, um den tatsächlichen Wert eines Finanzprodukts von irrationalen Kursbewegungen zu separieren --
die Analyse von Realmarktdaten offenbart langfristige Gleichgewichtsniveaus, zu dessen Rückkehr untersuchte Kursprozesse tendieren.
Verzögerte Wechselwirkungen zwischen unterschiedlichen Finanzprodukten helfen zusätzlich, Überreaktionen zu erkennen.
Erkenntnisse der Martingal- und Portfoliotheorie werden bei der Definition des Handelssystems mit dem Ziel kombiniert,
identifizierte Fehlbewertungen in gleichmäßige Gewinne zu überführen. Auf diese Weise wird ein nachhaltiger und sicherheitsorientierter Vermögensaufbau begünstigt.
Um möglichst präzise Aussagen über den Erfolg des Handelssystems treffen zu können, werden Simulationen auf künstlichen und realen Kursdaten untersucht.
Ausgewählte Performance- und Risikomaße werden dabei einerseits modellbasiert ausgewertet, um den Einfluss einzelner Zeitreiheneigenschaften akkurat bestimmen zu können.
Andererseits werden Realmarktdaten genutzt, um einen unverfälschten Blick über den tatsächlichen Erfolg der theoretischen Überlegungen zu ermöglichen.
Für die Evaluation werden Finanzmarktdaten von Aktien, Rohstoffen und Wechselkursen im Bereich von 1968 bis 2018 untersucht.
Die abschließende finanzwirtschaftliche Auswertung offenbart an einem umfassenden Beispiel, dass das Handelssystem in der Dekade von 2008 bis 2018 stetige Gewinne
bei einem moderaten Risiko generiert hätte.
Fast Healthcare Interoperability Resources (FHIR) as a Meta Model to Integrate Common Data Models: Development of a Tool and Quantitative Validation Study
Authors: Pfaff Emily Rose , Champion James , Bradford Robert Louis , Clark Marshall , Xu Hao , Fecho Karamarie , Krishnamurthy Ashok , Cox Steven , Chute Christopher G , Overby Taylor Casey , Ahalt Stan
Published: September 2020

Background

In a multisite clinical research collaboration, institutions may or may not use the same common data model (CDM) to store clinical data. To overcome this challenge, we proposed to use Health Level 7’s Fast Healthcare Interoperability Resources (FHIR) as a meta-CDM—a single standard to represent clinical data.

Objective

In this study, we aimed to create an open-source application termed the Clinical Asset Mapping Program for FHIR (CAMP FHIR) to efficiently transform clinical data to FHIR for supporting source-agnostic CDM-to-FHIR mapping.

Methods

Mapping with CAMP FHIR involves (1) mapping each source variable to its corresponding FHIR element and (2) mapping each item in the source data’s value sets to the corresponding FHIR value set item for variables with strict value sets. To date, CAMP FHIR has been used to transform 108 variables from the Informatics for Integrating Biology & the Bedside (i2b2) and Patient-Centered Outcomes Research Network data models to fields across 7 FHIR resources. It is designed to allow input from any source data model and will support additional FHIR resources in the future.

Results

We have used CAMP FHIR to transform data on approximately 23,000 patients with asthma from our institution’s i2b2 database. Data quality and integrity were validated against the origin point of the data, our enterprise clinical data warehouse.

Conclusions

We believe that CAMP FHIR can serve as an alternative to implementing new CDMs on a project-by-project basis. Moreover, the use of FHIR as a CDM could support rare data sharing opportunities, such as collaborations between academic medical centers and community hospitals. We anticipate adoption and use of CAMP FHIR to foster sharing of clinical data across institutions for downstream applications in translational research.
Supervised Exercise Therapy Using Mobile Health Technology in Patients With Peripheral Arterial Disease: Pilot Randomized Controlled Trial (Preprint)
Authors: Paldán Katrin , Steinmetz Martin , Simanovski Jan , Rammos Christos , Ullrich Greta , Jánosi Rolf Alexander , Moebus Susanne , Rassaf Tienush , Lortz Julia
Published: September 2020

BACKGROUND

Mobile health interventions are intended to support complex health care needs in chronic diseases digitally, but they are mainly targeted at general health improvement and neglect disease-specific requirements. Therefore, we designed TrackPAD, a smartphone app to support supervised exercise training in patients with peripheral arterial disease.

OBJECTIVE

This pilot study aimed to evaluate changes in the 6-minute walking distance (meters) as a primary outcome measure. The secondary outcome measures included changes in physical activity and assessing the patients’ peripheral arterial disease–related quality of life.

METHODS

This was a pilot two-arm, single-blinded, randomized controlled trial. Patients with symptomatic PAD (Fontaine stage IIa/b) and access to smartphones were eligible. Eligible participants were randomly assigned to the study, with the control group stratified by the distance covered in the 6-minute walking test using the TENALEA software. Participants randomized to the intervention group received usual care and the mobile intervention (TrackPAD) for the follow-up period of 3 months, whereas participants randomized to the control group received routine care only. TrackPAD records the frequency and duration of training sessions and pain levels using manual user input. Clinical outcome data were collected at the baseline and after 3 months via validated tools (the 6-minute walk test and self-reported quality of life). The usability and quality of the app were determined using the Mobile Application Rating Scale user version.

RESULTS

The intervention group (n=19) increased their mean 6-minute walking distance (83 meters, SD 72.2), while the control group (n=20) decreased their mean distance after 3 months of follow-up (–38.8 meters, SD 53.7; P=.01). The peripheral arterial disease–related quality of life increased significantly in terms of “symptom perception” and “limitations in physical functioning.” Users’ feedback showed increased motivation and a changed attitude toward performing supervised exercise training.

CONCLUSIONS

Besides the rating providing a valuable support tool for the user group, the mobile intervention TrackPAD was linked to a change in prognosis-relevant outcome measures combined with enhanced coping with the disease. The influence of mobile interventions on long-term prognosis must be evaluated in the future.

CLINICALTRIAL

ClinicalTrials.gov NCT04947228; https://clinicaltrials.gov/ct2/show/NCT04947228
Context and Barriers to the Prescription of Nonoccupational Postexposure Prophylaxis Among HIV Medical Care Providers: National Internet-Based Observational Study in China (Preprint)
Authors: Ding Haibo , Ye Zehao , Tang Weiming , Huang Xiaojie , Wang Hui , Cui Sitong , Jiang Yongjun , Geng Wenqing , Xu Junjie , Shang Hong
Published: September 2020

BACKGROUND

Nonoccupational postexposure prophylaxis (nPEP) is an effective HIV biomedical prevention strategy. The research and use of nPEP are mainly concentrated in the developed world, while little is known about the knowledge, attitudes, and practices of nPEP among HIV medical care providers in developing countries.

OBJECTIVE

We aimed to assess the nPEP knowledge and prescribing practice among HIV medical care providers in mainland China.

METHODS

HIV medical care providers were recruited in China during May and June 2019 through an online survey regarding nPEP-related knowledge, attitudes, and clinical prescription experiences. Multivariable logistic regression was performed to identify factors associated with prescribing nPEP among HIV medical care providers.

RESULTS

A total of 777 eligible participants participated in this study from 133 cities in 31 provinces in China. Of the participants, 60.2% (468/777) were unfamiliar with nPEP and only 53.3% (414/777) of participants ever prescribed nPEP. HIV care providers who worked in a specialized infectious disease hospital (vs general hospital, adjusted odds ratio [aOR] 2.49; 95% CI 1.85-3.37), had practiced for 6-10 years (vs 5 or fewer years, aOR 3.28; 95% CI 2.23-4.80), had practiced for 11 years or more (vs 5 or fewer years, aOR 3.75; 95% CI 2.59-5.45), and had previously prescribed occupational PEP (oPEP, aOR 4.90; 95% CI 3.29-7.29) had a significantly positive association with prescribing nPEP. However, unfamiliarity with nPEP (aOR 0.08; 95% CI 0.05-0.11), believing nPEP may promote HIV high-risk behavior (aOR 0.53; 95% CI 0.36-0.77) or result in HIV drug resistance (aOR 0.53; 95% CI 0.36-0.77) among key populations, and self-reported having no written oPEP guideline in place (aOR 0.53; 95% CI 0.35-0.79) were negatively associated with nPEP prescription behavior.

CONCLUSIONS

HIV medical care providers have insufficient nPEP knowledge and an inadequate proportion of prescribing, which may impede the scale-up of nPEP services to curb HIV acquisition. The implementation of tailored nPEP training or retraining to HIV medical care providers would improve this situation.