bluuebunny/crossref_metadata_2025 huggingface dataset:
Controlling the reliability performance of a thermoelectriccooler undervariable heat load
Authors: Zaykov Vladimir P. , Mescheryakov Vladimir I. , Zhuravlov Yurii I.
Published: May 2023

The work is devoted to substantiation of possibility of reduction of failure rate of thermal mode support system when operating with variable load by control of reliability indicators of thermoelectric cooler. A mathematical model for evaluating the effect of variable thermal load on reliability indicators of a single-cascade thermoelectric cooler at a given temperature level of cooling, medium temperature, geometry of thermocouple branches for various current modes of operation is considered. The relationship between the cooler steady-state operation time and mass and heat capacity of the structure, relative operating current and temperature difference is presented. The results of thermal load relation with operating current, refrigerating factor, time to steady-state mode, energy input, heat dissipation capacity of the radiator, and relative failure rate are presented. Calculations have been madeat a given cooling temperature level, medium temperature, temperature differential, and thermocouple branch geometryfor various characteristic current operating modes. It is shown that with decreasing thermal load at a given design of thermoelectric cooler, the value of operating current decreases, thus increasing the probability of no-failure operation. The obtained relationship of thermal load with operating current and relative failure rate serves as primary information for design of thermoelectric system for providing thermal modes of thermally loaded elements with variable thermal load. Using the rate of change of temperature difference between the thermally loaded element and the cold electrode of the cooler as a control feature, it is possible to reduce the failure rate when the thermal load decreases, which contributes to increasing the average probability of no-failure operation.
Identification of long noncoding RNAs with aberrant expression in prostate cancer metastases
Authors: Sattari Mina , Kohvakka Annika , Moradi Elaheh , Rauhala Hanna , Urhonen Henna , Isaacs William B , Nykter Matti , Murtola Teemu J , Tammela Teuvo L J , Latonen Leena , Bova G Steven , Kesseli Juha , Visakorpi Tapio
Published: May 2023

Prostate cancer (PCa) is the second-most common cause of male cancer-related death in western industrialized countries, and the emergence of metastases is a key challenge in the treatment of PCa. Accumulating studies have shown that long noncoding RNAs (lncRNAs) play an important role in the regulation of diverse cellular and molecular processes during the development and progression of cancer. Here, we utilized a unique cohort of castration-resistant prostate cancer metastases (mCRPC) and corresponding localized tumors and RNA sequencing (RNA-seq). First, we showed that patient-to-patient variability accounted for most of the variance in lncRNA expression between the samples, suggesting that genomic alterations in the samples are the main drivers of lncRNA expression in PCa metastasis. Subsequently, we identified 27 lncRNAs with differential expression (DE-lncRNAs) between metastases and corresponding primary tumors, suggesting that they are mCRPC-specific lncRNAs. Analyses of potential regulation by transcription factors (TFs) revealed that approximately half of the DE-lncRNAs have at least one binding site for the androgen receptor in their regulatory regions. In addition, TF enrichment analysis revealed the enrichment of binding sites for PCa-associated TFs, such as FOXA1 and HOXB13, in the regulatory regions of the DE-lncRNAs. In a cohort of prostatectomy-treated prostate tumors, four of the DE-lncRNAs showed association with progression-free time and two of them (lnc-SCFD2-2 and lnc-R3HCC1L-8) were independent prognostic markers. Our study highlights several mCRPC-specific lncRNAs that might be important in the progression of the disease to the metastatic stage and may also serve as potential biomarkers for aggressive PCa.
DOHaD: A Menagerie of Adaptations and Perspectives: The interplay between early embryo metabolism and mitoepigenetic programming of development
Authors: Bruna de Lima Camila , Cristina dos Santos Érika , Sirard Marc-André
Published: May 2023

In brief

This review discusses advances in the knowledge of epigenetic mechanisms regulating mitochondrial DNA and the relationship with reproductive biology.

Initially perceived simply as an ATP producer, mitochondria also participate in a wide range of other cellular functions. Mitochondrial communication with the nucleus, as well as signaling to other cellular compartments, is critical to cell homeostasis. Therefore, during early mammalian development, mitochondrial function is reported as a key element for survival. Any mitochondrial dysfunction may reflect in poor oocyte quality and may impair embryo development with possible long-lasting consequences to cell functions and the overall embryo phenotype. Growing evidence suggests that the availability of metabolic modulators can alter the landscape of epigenetic modifications in the nuclear genome providing an important layer for the regulation of nuclear-encoded gene expression. However, whether mitochondria could also be subjected to such similar epigenetic alterations and the mechanisms involved remain largely obscure and controversial. Mitochondrial epigenetics, also known as ‘mitoepigenetics’ is an intriguing regulatory mechanism in mitochondrial DNA (mtDNA)-encoded gene expression. In this review, we summarized the recent advances in mitoepigenetics, with a special focus on mtDNA methylation in reproductive biology and preimplantation development. A better comprehension of the regulatory role of mitoepigenetics will help the understanding of mitochondrial dysfunction and provide novel strategies for in vitro production systems and assisted reproduction technologies, as well as prevent metabolic related stress and diseases.
UN ANÁLISIS DE LA DIALÉCTICA ENTRE LA ILUSTRACIÓN Y LA RELIGIÓN EN LA "FENOMENOLOGÍA DEL ESPÍRITU" DE G. W. F. HEGEL
Authors: Santiago Dacosta Alipio
Published: May 2023

El propósito de este artículo es el de justificar una interpretación genuinamente hegeliana de la dimensión religiosa en el pensamiento de Hegel, particularmente a partir de la Fenomenología del espíritu. Tanto la izquierda como la derecha hegeliana desarrollaron un carácter unívoco, o bien reduciendo el concepto hegeliano de lo divino a la razón natural o histórica, o bien pasando por alto que la concepción hegeliana de una divinidad inmanente resultaba incompatible con el cristianismo ortodoxo. Analizaremos en detalle los capítulos de la Fenomenología del espíritu que se centran en la Ilustración, en los cuales el autor se desmarca de forma más clara de lo que podría ser una religiosidad puramente deísta. Finalmente, la propuesta de Hegel consistirá en un modelo orgánico de estado, dentro del cual la religión sería aceptada como parte de la misma substancia ética que fundamenta las leyes de cada comunidad.
Un modo de resistir al biopoder: El lugar de la parrhesia en las reflexiones ético políticas de Michel Focault
Authors: Cadahia L.
Published: May 2023

La propuesta del presente artículo versa sobre la posibilidad de pensar la importancia del vínculo entre los conceptos de libertad y parrhesia dentro del proyecto filosófico de Michel Foucault. Para llevar a cabo esta tarea vamos a mostrar, por un lado, de qué manera emerge el problema de la libertad en los escritos foucaultianos. Estudiaremos que el giro suscitado entre el primero y el segundo momento del proyecto del filósofo plantea una vía que, a la vez que resuelve ciertas tensiones de los primeros análisis de la noción de poder, también abre un espacio de inteligibilidad para pensar de otra manera el vínculo entre libertad y poder. Asimismo, mostraremos en qué medida la noción de parrhesia abre un espacio para trabajar el problema de la libertad y su vínculo con la ética y la política.  Finalmente, la propuesta consiste en bosquejar cómo el concepto de la parrhesia, en los términos de un decir franco, emerge como un ejercicio de resistencia al biopoder.
La filosofía política de Pedro de Ribadeneyra y su influencia jurídica en la historia de España
Authors: López Muñoz M.A.
Published: May 2023

Desde el análisis de las condiciones socio-económicas y políticas de finales del siglo XVI, el artículo expone el pensamiento político de Pedro de Ribadeneyra y lo proyecta sobre el tratamiento constitucional que, desde 1812 hasta 1978, ha tenido la libertad de conciencia en España.
La Filosofía Política moralista de Quevedo frente a la pragmatista-belicista de Nicolás Maquiavelo
Authors: Barrientos Rastrojo J.
Published: May 2023

Este trabajo describe los contextos que unieron a las humanidades y el poder en diversos momentos de la historia. Una concreción de esta situación se ubica en los siglos XVI y XVII. Nos detenemos en esta época porque ella crea un retroceso del progreso intelectual en la Filosofía Política. Así, el avance filosófico de los argumentos de El príncipe (1516) de Maquiavelo involuciona en obras posteriores de Filosofía Política, como la de Francisco de Quevedo (1621). Nuestro artículo compara los mencionados textos de Quevedo y Maquiavelo y añade un tercer espejo: la acción concreta de aquel a quien Quevedo miraba en el momento de elaborar su texto, el Conde-Duque de Olivares. Con este juego de miradas, concluiremos explicitando el modo en que el valido de Felipe IV supo sacar provecho de las enseñanzas de Quevedo; aunque, no debemos dejar de señalarlo, pareció aliarse más cerca del protegido de los Médicis que del autor de El buscón.
El Caballero de la Locura y su ambigüedad: Don Quijote entre Unamuno y Zambrano
Authors: Trapanese E.
Published: May 2023

El ensayo propone cotejar las interpretaciones que Miguel de Unamuno y María Zambrano ofrecen de Don Quijote de la Mancha de Miguel de Cervantes. El escritor vasco parece centrar su atención en el carácter trágico de Don Quijote y en el rescate de la figura de Sancho Panza, reivindicando la autonomía de los personajes frente al autor de la obra y su función clave en la interpretación de España. A partir de las reflexiones de su maestro, María Zambrano consigue ver en la figura del caballero la ambigüedad de la existencia humana, producto de la tensión entre los sueños y la acción de vigilia de la conciencia. Para salvarse de la ambigüedad y rescatar la vida, Don Quijote, como todo ser humano, necesita encontrar una imagen que le enamore, necesita encontrar y seguir a “su” Dulcinea.
Sobre la autonomía de los genes
Authors: Martín Marsá S.
Published: May 2023

Durante las últimas décadas hemos asistido al avance imparable de la genética y los descubrimientos en este campo han suscitado el interés creciente de los filósofos de la biología. No obstante, la pregunta ¿qué es un gen? sigue sin una respuesta definitiva y no existe un posicionamiento claro y unívoco por parte de la ciencia. En algunos momentos se ha llegado a considerar el gen como una especie de agente autónomo, responsable último de la evolución y del desarrollo organísmico, pero la nueva ciencia genómica dibuja un panorama diferente y ha empezado a cuestionar algunas de las metáforas científicas más comunes.
Philosophy and education in Spain: Luzuriaga and the Revista de Pedagogía
Authors: Casado Marcos de León A.
Published: May 2023

La Revista de Pedagogía, fundada en 1922 por Lorenzo Luzuriaga, es una excelente atalaya para analizar la relación entre filosofía y educación en España. Aunque era una publicación “pedagógica”, dirigida a los profesionales de la enseñanza, no por ello descuida la “perspectiva filosófica” como dimensión indispensable en la teoría y la práctica educativas. La significativa presencia de conocidos filósofos españoles y extranjeros como colaboradores habituales, constituye una muestra ejemplar de interés y colaboración entre ambos campos.
Aprendiendo sobre el aprendizaje a través de la tecnología
Authors: Kouppanou A.
Published: May 2023

La tecnología, por medio de su naturaleza múltiple y ubicua, penetra y da forma constantemente a nuestras experiencias, pensamientos y modos de aprender. La filosofía de la tecnología puede ofrecernos una mayor sensibilidad en esta cuestión. Sin embargo, como área tiene muchas perspectivas diferentes que ofrecer. En este artículo, presentaré algunas de estas perspectivas pero mantendré que la filosofía de la tecnología de Heidegger que es considerada como "esencialista" aporta una especial profundidad filosófica a la discusión acerca de los aprendices y el mundo desde el cual aprenden.
La filosofía de la educación y su papel en la actualidad
Authors: Misawa K.
Published: May 2023

Podría decirse que la filosofía de la educación está peor considerada y es menos apreciada que cualquier otra disciplina filosófica. Este artículo analiza críticamente el destacado intento por superar este impasse realizado por el filósofo inglés Wilfred Carr. Él anima a que la disciplina tome una nueva forma de carácter distinto al de disciplina académica. Sin embargo se indica, en contra de Carr, que la naturaleza social y educativa del conocimiento constituye la pieza central de la investigación filosófica acerca del conocimiento humano.
La educación en pensadores españoles contemporáneos
Authors: Sánchez-Gey Venegas J.
Published: May 2023

Destacamos el pensamiento educativo de tres maestros de la filosofía española contemporánea: Miguel de Unamuno (1864-1936), José Ortega y Gasset (1883-1955) y María Zambrano (1904-1991). En estos autores observamos, principalmente, el aprecio que sienten por el sentido formativo de la filosofía y su preocupación por un saber de experiencia. Al mismo tiempo, sugerimos los temas más singulares en la atención educativa de cada autor.
El poema: su lectura como Lichtung
Authors: Lorente Martínez S.
Published: May 2023

En este trabajo trato de mostrar desde el pensamiento de Heidegger que el poema es el lugar para el acontecer del ser. Para ello argumento en primer lugar que el poema no es una sustancia sino que consiste solo en su lectura y/o recitación. Después hago ver el carácter multívoco de la palabra poética para explicar desde ahí que el poema se lee desde una determinada situación hermenéutica y cómo gracias al lenguaje puede repercutir sobre ella. Con ello se abriría la posibilidad de un cambio de comprensión de ser.
El método socrático y su aplicación pedagógica contemporánea
Authors: Castro Faune C.
Published: May 2023

Se aborda críticamente la función que Martha Nussbaum atribuye al método socrático en su proyecto de fundamentación de la educación liberal. Primero, se describe el programa educativo liberal. Luego, se analiza la definición y la función que cumple el método socrático. Finalmente, se analizan tres argumentos que sustentan el proyecto: la definición de la ironía socrática, la discontinuidad doctrinal de los diálogos, y la concepción de Sócrates como partidario de la democracia.
¿Son los derechos temporales concesiones temporales? ensayo de genealogía
Authors: Velasco Arias Gonzalo
Published: May 2023

El presente artículo trata de caracterizar la “invención de lo social” como una estrategia para neutralizar el antagonismo capital trabajo que domina el siglo XIX. Para ello, se sigue un método arqueológico y genealógico, que toma en consideración las transformaciones epistemológicas que posibilitaron el advenimiento de la racionalidad social, así como las luchas de poder en las que estas transformaciones deben ser enmarcadas.
El sujeto político y la transformación social en Judith Butler y Seyla Benhabib
Authors: Velasco Lázaro Ana
Published: May 2023

El presente estudio aborda el problema de la transformación social en la teoría feminista contemporánea a partir de las perspectivas de dos autoras: Judith Butler y Seyla Benhabib. Una manera diferente de entender el sujeto les conducirá a diferentes estrategias políticas, aunque mantengan una meta común: la posibilidad de la ampliación del discurso con la finalidad de ser inclusivo y la permanencia de éste para garantizar el derecho a la igualdad. El objetivo es mostrar, a partir de los puntos clave en los que ambos proyectos filosóficos se encuentran, qué cuestiones deberá atender una teoría feminista inclusiva en el actual contexto de globalización.
The Problem of Human Rights in Direct Democracy
Authors: KRZYWOSZYNSKI Przemyslaw
Published: May 2023

El objetivo principal de este artículo es ilustrar la relación entre los derechos humanos y los referendos. En la teoría del derecho internacional y constitucional, los derechos humanos son considerados fundamentales. Un Estado democrático moderno debe garantizar la protección de los derechos humanos como la dignidad, la libertad y la propiedad de los bienes, así como garantizar la igualdad y los derechos sociales y económicos. Sin embargo, desde sus inicios, los fundamentos de estos derechos han sido asociados con el conflicto y en épocas como la Revolución francesa y el tiempo de terror, en situaciones como dictaduras y sistemas totalitarios a menudo se abusa de términos tomados del vocabulario de los derechos humanos, entre ellos la libertad e igualdad.
Como la institución más básica de la democracia directa moderna, el referéndum parece ser un excelente medio de protección de los derechos humanos. Sin embargo, los referendos también ofrecen oportunidades para limitar estos derechos, y no sólo por parte de regímenes totalitarios y autoritarios que buscan utilizar esta institución para legitimar su poder. En las democracias, cuando se pregunta acerca de un tema muy difícil (por ejemplo, un problema moral) a menudo son impulsados por emociones durante las campañas y la hora de votar. En relación con los derechos humanos, los referendos por lo tanto puede ser un arma de doble filo.
 As the most basic institution of modern direct democracy, the referendum would seem to be an excellent means of protecting human rights. However, referendums also provide opportunities for limiting these rights, and not only by totalitarian and authoritarian regimes seeking use this institution to legitimize their power. In democracies, when people are asked about a very difficult subject (e.g. a moral problem) they are often driven by emotions during the campaigns and when voting. In relation to human rights, referendums can thus be a double-edged sword.
El secuestro del sujeto contemporáneo. De Karl Mannheim (ideología) y Mario Perniola (sensología) al riesgo del extravío antropológico en el siglo XXI
Authors: BARRIENTOS RASTROJO José
Published: May 2023

Este trabajo explica la categoría ideología a partir de la obra Ideología y utopía de K. Mannheim, la extrapola al ámbito de los sentimientos desde la propuesta sensológica de M. Perniola (Del sentir, 2002) y, finalmente, desciende a los peligros de la ideología y la sensología cuando ambos fenómenos conducen a un rapto del ser humano. Evitados los riesgos del secuestro, se proponen líneas que abran la posibilidad de un sujeto contemporáneo que aprehenda las nociones citadas (ideas y sentimientos) de forma autónoma.
Hydrodynamic normalization conditions in the theory of degenerate Beltrami equations
Authors: Gutlyanskiĭ V.Ya. , Ryazanov V.I. , Sevost’yanov E.A. , Yakubov E.
Published: May 2023

We study the existence of normalized homeomorphic solutions for the degenerate Beltrami equation fz = μ(z )f  in the whole complex plane C , assuming that its measurable coefficient μ(z ), | μ(z ) |<1 a. e., has compact support and the degeneration of the equation is controlled by the tangential dilatation quotient KT μ (z , z0) . We show that if KT μ (z , z0) has bounded or finite mean oscillation dominants, or satisfies the Lehto type integral divergence condition, then the Beltrami equation admits a regular homeomorphic   W1,1loc solution f with the hydrodynamic normalization at infinity. We also give integral criteria of Calderon-Zygmund or Orlicz types for the existence of the normalized solutions in terms of KT μ (z , z0) and the maximal dilatation Kμ (z ) .
Моделювання квазістатичного поширення тріщини у в’язкопружному ортотропному середовищі в рамках підходу інкременталізації конститутивних рівнянь
Authors: Селіванов М.Ф. , Фернаті П.В.
Published: May 2023

Розглядається алгоритм для моделювання процесу розвитку тріщини повзучості у в’язкопружному орто- тропному середовищі. Цей алгоритм поєднує в’язкопружну інкрементну формулу та процедуру моделюван- ня квазістатичного руйнування; алгоритм реалізовано в рамках методу скінченних елементів і проілюстро- вано числовим прикладом визначення зміни напружено-деформованого стану в околі зони передруйнування з часом. Як модель тріщини вибрано модель когезійної зони з нерівномірним законом зчеплення–відриву, яка описує наявну біля фронту тріщини зону передруйнування. Зростання тріщини описується в рамках деформаційного критерію. В числовому прикладі розглянуто поширення крайової тріщини в пластині з в’язкопружного ортотропного матеріалу, модулі релаксації якого описано однією експоненціальною функці- єю. Як закон зчеплення–відриву вибрано близький до рівномірного закон згладженої трапецеїдальної форми, що задовольняється для кожного дискретного моменту часу, знайденого запропонованим алгоритмом з ура- хуванням поточної геометрії тріщини.
Bone fractures in children and adolescents: a frequent problem with a diverse aetiology
Authors:   Department of Paediatrics, Neonatal Pathology and Metabolic Bone Diseases, Medical University of Lodz, Łódź, Poland, Jakubowska-Pietkiewicz Elżbieta
Published: May 2023

Bone fractures in children and adolescents are primarily an orthopaedic problem; however, frequent fractures or multiple fractures at a time require a more extensive diagnostic investigation performed by a paediatrician, endocrinologist and even a geneticist. It is estimated that one in three children aged up to 17 years will experience a bone fracture. The frequency of fractures rises with age, peaking at 11–14 years. The majority of fractures happen as a result of trauma; however, some of them are a sign of genetic diseases (osteogenesis imperfecta, osteopetrosis) or mineral imbalance (metabolic bone disease of prematurity, rickets, osteoporosis). Bone fractures in small children require particular attention, since they may be a sign of not only systemic disorders, but also of battered child syndrome. Not only fractures of long bones, but also fractures of the vertebrae are an underappreciated problem in young patients. They may be spontaneous or associated with inflammatory, autoimmune or neoplastic diseases. Glucocorticoids that are used to treat these diseases are considered to be the main risk factor for the development of steroid-related osteoporosis, regardless of the patient’s age. Due to the diverse aetiology of bone fractures in children and adolescents, the cooperation of multiple specialists in the diagnostic investigation of calcium and phosphate imbalance and disorders of bone mineralisation is important.
Diagnostic and therapeutic difficulties in PFAPA: a case report
Authors:   Department of Paediatrics, Paediatric Nephrology and Allergology, Military Institute of Medicine – National Research Institute, Warsaw, Poland, Tomaszewska Agata , Piotrowska-Lis Karolina ,   Students’Scientific Group, Department of Paediatrics, Paediatric Nephrology and Allergology, Military Institute of Medicine – National Research Institute,Warsaw, Poland, Rustecka Agnieszka ,   Department of Paediatrics, Paediatric Nephrology and Allergology, Military Institute of Medicine – National Research Institute, Warsaw, Poland, Kalicki Bolesław ,   Department of Paediatrics, Paediatric Nephrology and Allergology, Military Institute of Medicine – National Research Institute, Warsaw, Poland
Published: May 2023

Recurrent fever syndromes are autoinflammatory diseases. In their pathogenesis, no autoantibodies or autoreactive T-lymphocytes are found. Innate immunity and adaptive immunity are of great importance in this case. In the mid-latitudes, the most common syndrome is periodic fever with aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA), which mainly affects children under 5 years of age. Fevers occur cyclically, on average every 26–36 days. Characteristic features of PFAPA include the absence of any symptoms between fever episodes and undisturbed growth and development of the child. In laboratory tests, during a fever episode, elevated white blood cell count and an increase in inflammatory markers are observed. The recommended treatment is the use of glucocorticoids. In some cases, the use of colchicine or even an interleukin-1 receptor antagonist (anakinra) may be considered. The aim of this paper is to present the case of a 3.5-year-old boy hospitalised in the Department of Paediatrics, Nephrology and Paediatric Allergology of the Military Institute of Medicine due to recurrent episodes of fever with enlarged lymph nodes, occurring at regular intervals, as well as to draw attention to the difficulties encountered during the diagnosis of recurrent febrile episodes.
Perception of family relationships and personal integration in young women suffering from anorexia nervosa
Authors:   Institute of Psychology, Cardinal Stefan Wyszynski University, Warsaw, Poland, Zagórska Wanda , Starzomska-Romanowska Małgorzata ,   Institute of Psychology, Cardinal Stefan Wyszynski University, Warsaw, Poland, Skowron Katarzyna ,   Institute of Psychology, Cardinal Stefan Wyszynski University, Warsaw, Poland
Published: May 2023

The presented study concerns finding an answer to the question of perceived quality of relationships in the family of origin and personal integration, as well as the link between these variables among young women suffering from anorexia nervosa. The aim of the study was to determine: (1) the manner of assessing relationships in the family of origin by women suffering from anorexia; (2) the level of their personal integration (as a whole and in relation to its components, particularly trust, autonomy, and a sense of identity); and (3) the associations between the quality of family relationships and personal integration along with its components (psychosocial resources/ego qualities). The intergroup differences were verified in the scope of three types of family relationships: autonomy/control, consistency and communication, and the level of overall personal integration and seven out of eight (due to the age of the respondents) ego qualities identified in the theory proposed by Erikson. A total 60 women aged 18 to 24 years (M = 19.15, standard deviation, SD = 1.89) took part in the study. The research group comprised 29 women with a diagnosis of anorexia nervosa, whereas the control group consisted of 31 healthy women. The Family Relationship Questionnaire (KRR-3) developed by Plopa and Połomski (2010), the Personal Integration Questionnaire (KINTO) authored by Zagórska, Migut and Jelińska (2014), and an original sociodemographic survey were applied. It was assumed that women suffering from anorexia, compared to healthy women, would assess relationships in the family of origin differently, particularly the relationship with the mother, and that they were less strongly integrated, mainly in relation to such resources as trust, autonomy, and a sense of identity. It was also believed that there was a link between the assessment of family relationships and personal integration. The hypotheses concerning overly protective and controlling parental attitudes in women suffering from anorexia were confirmed. They were also found to have a lower level of personal integration and sense of identity. A small number of associations that are difficult to interpret in the case of the relationship with the mother were found between the perceived quality of family relationships and the psychosocial resources of women suffering from anorexia, which may be attributed to denial commonly occurring in persons suffering from anorexia. The picture of the matrix of the studied relationships turned out to be different in both groups, particularly with regard to the relationship between personal integration and the three attitudes of the mother.
Amigos, propaganda y diplomacia informal: la actuación de la RDA en España a través del asociacionismo de amistad (1979-1990)
Authors: Ramos-Diez-Astrain Xavier-María
Published: May 2023

Las asociaciones de amistad constituyeron en su momento actores transnacionales relevantes en las relaciones Este-Oeste. En España, en 1979 nació la Asociación Guillermo Humboldt para el Conocimiento y la Amistad entre España y la República Democrática Alemana, que, en conexión con la Liga für Völkerfreundschaft de la RDA, estaba llamada a servir de instrumento de propaganda y diplomacia informal. El examen de la actuación propagandística de la Liga für Völkerfreundschaft en España, del papel desempeñado en la misma por la Asociación Guillermo Humboldt y de sus limitaciones constituye el objetivo esencial de este artículo, que utiliza fuentes españolas y alemanas y realiza un ejercicio comparativo con organizaciones similares vinculadas a la Unión Soviética.
El prestigio cultural de la mímesis ritual
Authors: García-Sánchez Rafael , García-Córdoba Miguel , García-León Josefina , Vázquez-Arenas Gemma
Published: May 2023

En general, la mímesis puede ser de orden ritual, visual o cognitiva. La mímesis más antigua tiene lugar en el marco de los ritos, pero en tiempos de empobrecimiento simbólico, muchos de ellos han perdido su antiguo vigor y, a veces, han quedado reducidos a mero folclore. La mímesis visual fue abordada por Platón de la que afirmó que no permitía conocer la realidad con la profundidad ni con la perfección con que era posible hacerlo mediante el rito o la reflexión. Aristóteles profundizó en una mímesis de índole cognitiva, señalando que a partir de ella podían conocerse las leyes de la naturaleza, sus fines y el modo en que opera para conseguirlos. Al analizar estos tipos de mímesis trataremos de poner de relieve que una forma legítima y eficaz de reconectar al hombre con el mundo y con la realidad es la puesta en valor del rito.
Peptide extraction from silver carp (Hypophthalmichthys molitrix) scales via enzymatic hydrolysis and membrane filtration
Authors: Zu Xiao-yan , Huang Ya-qi , Zhao Ya-jing , Xiong Guang-quan , Liao Tao , Li Hai-lan
Published: May 2023

In this work, peptides were extracted from Silver carp (SC) scales via protease hydrolysis and separated using two membranes (M1 and M2). The results revealed that the water: SC scale ratios of 50.6 mL/g, alkaline protease 1 (AP1) dose of 2313.6 U/mL, and pH of 8.14 were the optimal hydrolysis conditions, and the peptide yield reached 88.77 ± 0.32%. The optimal conditions of peptide separation were clarified: the operating pressure of the M1 (M2) was 0.25 (0.4) MPa, the liquid temperature was 30°C, and the operation time was 65 min. In this case, the permeability of the M1 (M2) reached 91.73 ± 96% (79.83 ± 7.23%), and the average molecular weight of the peptides was 758 Da (576 Da). Compared with M1 peptides, M2 peptides contained more acidic and aromatic amino acids exhibiting free-radical scavenging and tyrosinase inhibition properties. It might provide a way to utilize SC scales as a promising material to produce bioactive peptides.
Natural phytochemicals as P2X7 receptor inhibitors for the treatment of inflammation-related diseases
Authors: Niu Qian , Li Jin-cai , Zhang Meng , Zhou Peng
Published: May 2023

P2X7 receptor (P2X7R) inhibition is critical for reducing the overactivation of its downstream signaling pathway in autoimmune diseases. Phytochemicals are a source of medicinal compounds for various diseases and contribute to the development of effective and safe P2X7R-targeted drugs. This review is aimed at identifying and screening novel safe, effective, and economically feasible inhibitors of P2X7R from phytochemicals extracted from food and plants. The results of the docking study revealed that the VINA scores of dihydrotanshinone, baicalin, berberine, genistin, dioscin, resveratrol, apigenin, cannabidiol, esculin, and luteolin were lower than or equal to that of A740003 (P2X7R inhibitor). The VINA scores of dihydrotanshinone and baicalin were lower than or equal to JNJ47965567 (P2X7R inhibitor). Dihydrotanshinone and baicalin can be used as lead compounds for P2X7R inhibition. These active ingredients will contribute to the discovery of lead compounds and the development of innovative P2X7R agents for the treatment of autoimmune diseases.
A catequese católica: caminhos da secularização ou da abertura?
Authors: Diniz Lira André Augusto , Adam Júlio Cézar
Published: May 2023

No século XX, foram muitas as mudanças ocorridas na Igreja Católica Apostólica Romana (ICAR) na liturgia, no entendimento de questões contemporâneas, na evangelização e na catequese, entre outras. Essas se processaram sob alegações contrapostas nas quais figura a disputa sobre a interpretação legítima da ortodoxia católica. Este artigo apresenta, inicialmente, esses posicionamentos em disputa, vinculando a catequese à secularização ou à abertura da ICAR; considera, a seguir, uma análise mais atual dos limites desse tipo de abordagem da secularização; e, finalmente, debruça-se sobre os três últimos Diretórios para a catequese [Diretório Catequístico Geral (1971), Diretório Geral para a Catequese (1997), do Diretório para a Catequese(2020)], procurando nesses o movimento de constituição oficial da ICAR.
Secularismo e Populismo Religioso em Portugal
Authors: Botelho Moniz Jorge , Brissos-Lino José
Published: May 2023

Para se compreender o fenômeno do populismo em Portugal deve-se observar seu subtipo religioso. A desprivatização da religião permite identificar dois tipos de populismo religioso: modernofobia e islamofobia. Partindo dessa conceitualização, o artigo analisa o discurso populista religioso associado às dimensões identitária e cultural de partidos da direita portuguesa como o Chega! e o CDS-PP. Apesar das diferenças entre ambos, especialmente no modo como recorrem a argumentos religiosos no seu discurso político, o atual contexto político nacional segue a tendência de desprivatização religiosa, abrindo caminho para a religião e o populismo religioso aumentarem sua proeminência no espaço público e nas agendas políticas.
A recepção focolarina dos documentos do CELAM: anotações de uma pesquisa documental e bibliográfica
Authors: Santana Cleiton Costa de , Fernandes Márcio Luiz
Published: May 2023

O presente artigo, resultado de pesquisa bibliográfica e documental, prescruta um dos segmentos do catolicismo presente no Brasil a fim de evidenciar como nasceu a proposta da Economia de Comunhão. Nossa pesquisa lança luz sobre aspectos desconhecidos da história recente da Igreja no Brasil: a percepção de um movimento eclesial quanto à atuação do episcopado no período da ditadura militar; a autocompreensão do Movimento dos Focolares frente às críticas dirigidas pelo episcopado aos Novos Movimentos Eclesiais; a posição das lideranças dos Focolares no Brasil quanto à atuação política do episcopado durante a ditadura; o processo de recepção das indicações do magistério latino-americano, por parte do Movimento dos Focolares, no qual a “opção preferencial pelos pobres” não significou a incorporação das práticas e da linguagem então hegemônicas no contexto eclesial brasileiro.
Apresentação: A reconfiguração do catolicismo no Brasil no contexto da secularização
Authors: Sell Carlos Eduardo , Moniz Jorge Botelho
Published: May 2023

Apesar do aumento da diversidade confessional no campo religioso, o catolicismo ainda é a religião numericamente predominante no Brasil. Tomando esse fato como ponto de partida, o objetivo deste dossiê é refletir sobre a Igreja Católica e catolicismo no Brasil no contexto das múltiplas formas de secularização.
Momentos do processo de secularização da educação no Brasil: da fusão à cisão
Authors: Ciarallo Gilson
Published: May 2023

Este artigo examina momentos do jogo de interações entre as esferas educação e religião no Brasil. Essas esferas se articularam numa movimentação peculiar em direção à secularização da educação nos fins do século XIX, instituindo o seu caráter laico. Quatro momentos são colocados em perspectiva considerando as influências mútuas entre essas esferas: fusão e monopólio, desmonopolização, diversificação e cisão. Reunindo informações de documentos produzidos pela Igreja e Estado, periódicos da época e estudos sobre essas configurações sociais, conclui-se que a esfera educacional autonomizou-se em relação à religião. Embora o ensino mantido por instituições religiosas tenha permanecido e se reproduzido, o processo de secularização da educação se efetivou, dando forma a uma composição social peculiar que ajuda a compreender a especificidade da experiência brasileira dentre as experiências de modernização no Ocidente.
Dermatologic toxicity of high doses of tiothepa in children. Case report
Authors: Aliev Teimur Z. , Potemkina Tatiana I. , Belysheva Tatiana S. , Valiev Timur T. , Sergeenko Karina A. , Kostareva Irina A. , Kudaeva Lana M. , Machneva Elena B. , Ushakova Tatiana L. , Polyakov Vladimir G. , Kirgizov Kirill I. , Varfolomeeva Svetlana R.
Published: May 2023

Hematopoietic stem cell transplantation (HSCT) is a treatment modality for a number of severe malignant and non-neoplastic diseases. Autologous hematopoietic stem cell transplantation (auto-HSCT) improves outcomes in patients with solid and hematological malignancies. Skin lesions at the auto-HSCT stage are quite common and represent an important diagnostic and therapeutic problem. The most significant causes of skin lesions in auto-HSCT are drug toxicity, infectious and viral lesions. Each of the complications can manifest itself to varying degrees as well as combine with others, having a significant negative on the patient’s condition, posing a threat to the patient’s life in severe cases.
Severe Neonatal Skin Infection: Clinical Case
Authors: Efimov Denis K. , Goncharova Ekaterina A. , Khachaturyan Maria A. , Turti Tatyana V. , Makarova Lyudmila M.
Published: May 2023

Background. Pyoderma is the most common skin infectious disease of early age, it is a group of dermatoses characterized by purulent-inflammatory damage to the skin, dermal appendages, and subcutaneous fat. The diagnosis is based on medical history and physical examination. The main treatment methods are antibacterial therapy (local or systemic) and antiseptic skin toilet. Some forms of deep pyoderma require surgical interventions.

Clinical case description. Girl A., 14 days of life, was admitted to the neonatal department of infectious disease with complaints of the mass in the left shoulder joint area. Historical information: 27 years old mother was not observed in any maternity welfare centre; chorioamnionitis was revealed at admission to the obstetric hospital. She received broad-spectrum antibacterial therapy perinatally. A girl from spontaneous vaginal delivery born on the 39th week with body weight of 2700 g, body length of 50 cm, and APGAR score of 8/9, she was breastfed. The condition on admission was severe. There were multiple indurated rash elements (pustules with turbid fluid) on the skin of the chest, limbs, and back. Skin desquamation was noted. There was hyperemia area up to 3.5 × 1.5 cm in the left shoulder joint area, with soft-elastic consistency, fluctuation symptom was positive. Complete blood count has shown: leukocytosis and neutrophilosis. Methicillin-resistant Staphylococcus aureus (MRSA) was revealed in blood via PCR method, in hemoculture, and in throat and nose cultures. C-reactive protein level was increased. Abscess culture — MRSA. Screening by immunological assay was performed to exclude primary immunodeficiency. Abscess incision and drainage were performed; 5 mL of thick yellow-green pus was obtained. Combination therapy with broad-spectrum antibiotic was carried out.

Conclusion. There was positive dynamics on the administered therapy: the child condition was satisfactory, skin cleared of infectious rash, abscess was sanitized, laboratory parameters normalized, the child had no fever.
Linguistic accuracy and authenticity of the content of the Russian version of the module of gastrointestinal symptoms of the PedsQL™ questionnaire for pediatric patients
Authors: Arakelyan Anna L. , Surkov Andrey N. , Baranov Aleksander A. , Namazova-Baranova Leyla S. , Gorev Valeri V. , Moskvina Elena B. , Skvorcova Tamara A. , Nikitin Artem V. , Chernikov Vladislav V.
Published: May 2023

Background. Health Related Quality of Life (HRQL) is a person’s perception of the effect of a disease on physical, social and psychological functioning and wealth. Questionnaires that help assess the HRQL can give a concept of child’s state, identify arcane issues and they are of great importance for a full understanding of how the state of health affects the child. Universal HRQL tools allow to compare results with general parameters, indicators with specific symptoms better reflect clinically significant moments. The most widespread in the Russian Federation was the general PedsQLTM 4.0 questionnaire, widely used in practice to assess HRQL in children with various pathologies. Objective.

The aim of the study is to describe the analysis of linguistic accuracy and authenticity of the content of the Russian version of the module of gastrointestinal symptoms of the PedsQLTM questionnaire, measuring HRQL, in children with gastrointestinal disorders (GIDs).

Materials and methods. The establishment of linguistic accuracy and authenticity of the content was carried out according to international standards. The process included forward translation, scientific assessment and coordination, reverse translation, verification of the reverse translation and interviews with 17 children aged 5–18 years with symptoms of GIDs and 20 parents of children with symptoms of GIDs aged 2–18 years.

Results. The Russian version of PedsQLTM module of gastrointestinal symptoms (report from children 5-18 years old, report from parents for children 2–18 years old) was developed without significant difficulties. Eight questions required discussion after the forward translation, one change was made after the reverse translation, and three changes were made after the study of the symptom’s module by patients and parents.

Conclusion. A conceptually equivalent version of the of PedsQLTM module of gastrointestinal symptoms in Russian has been developed for children aged 2–18 years. It allows to improve the assessment of HRQL in children with GIDs in the Russian Federation. To assess authenticity and reliability of the Russian version of the module, it’s recommended to conduct further research using a larger sample
Symposium “Lessons of Infections in the Post-Pandemic Period”
Authors: Editorial Article
Published: May 2023

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EXPERIMENTAL ANALYSIS AND PERFORMANCE OF A WASTE PLASTICS PYROLYSIS SYSTEM FOR BIOFUEL PRODUCTION
Authors: Adeyanju Anthony Ademola , Manohar Krishpersad
Published: May 2023

The conversion of waste plastics to biofuel using thermal pyrolysis was investigated in this study. In order to thermally degrade waste plastics in the absence of oxygen, a fixed-bed pyrolysis apparatus was designed and constructed. The experimental investigation of the liquid fuel generated was carried out by examining various fuel characteristics such as flash point, calorific value, pour point, and the kinematic viscosity. The properties were compared with the conventional Petrol and Diesel, and correlations in the properties evaluated were discovered. The impact of temperature and heating rate on the pyrolysis system was investigated, and it was observed that increasing the heating rate reduces the time required for pyrolyzed product degradation while increasing the amount of thermal energy delivered during the period. Nevertheless, as the quantity of deteriorated plastics grows per unit of time, so does the rate of deterioration, which increases the temperature. The high-temperature rise accelerates the evaporation process, which averted side cracking in the gaseous form. Furthermore, the effect of particle size on the pyrolysis system was investigated and it was observed that smaller size plastic particles produced more oil faster.
Peculiarities of the flame formation of a propane-air mixture in a narrow channel
Authors:   Tomsk State University (Tomsk, Russian Federation), Moiseeva Kseniya M. , Kantarbaeva Aruzhan I. ,   Tomsk State University (Tomsk, Russian Federation), Krainov Aleksey Yu. ,   Tomsk State University (Tomsk, Russian Federation)
Published: May 2023

This paper presents a numerical study of the features of propane-air mixture flame propagation in a narrow cylindrical channel. The main purpose of the study is to determine the effect of the channel width on the combustion characteristics of a propane-air mixture with a composition close to stoichiometric. The problem is formulated using the methods of reactive gas dynamics. The solution method is based on the Van Leer method for determining flows on the faces of computational cells. The peculiarities of the combustion front formation and its propagation along the channel are revealed and analyzed. The formation of the curved flame front is shown to have a cyclical nature. The visible flame velocity is obtained as a function of the channel radius. The proposed physical and mathematical model can be used to determine the thermal conditions of operating cylindrical burners.
A thermal state of a small satellite at various packing density of electronic circuit boards
Authors:   Tomsk State University (Tomsk, Russian Federation), Belov Sergey V. , Bel’kov Аleksey V. ,   Tomsk State University (Tomsk, Russian Federation), Zhukov Andrey P. ,   Tomsk State University (Tomsk, Russian Federation), Pavlov Mikhail S. ,   Tomsk State University (Tomsk, Russian Federation), Ponomarev Sergey V. ,   Tomsk State University (Tomsk, Russian Federation)
Published: May 2023

To reduce the cost of CubeSat satellites, an industrial level of performance for radio-electronic components designed for ground operations is applied. A specific tem-perature range should be maintained for such electronic components to operate under space flight conditions. Since the CubeSat spacecraft does not have an active temperature regulation system, the thermal conditions are determined by the balance between inactive absorbed and radiated energy flows, including internal heat release. This paper considers the effect of heat release from circuit boards of different packing density in the electronic equipment on the 1U CubeSat thermal conditions. Both the absorbed radiation from ex-ternal sources, the radiation from the CubeSat external surfaces, the inner heat release, and the re-radiation between the surfaces within the spacecraft are taken into account. The formulated problem is solved numerically. The results show the effect of circuit board packing density on the amplitudes of temperature oscillations and on the average temperatures of satellite structural elements.
İdeal Okul Yöneticisi Ölçeğinin Geliştirilmesi
Authors: OYNAR Görkem , ŞAHİN İdris
Published: May 2023

Bu çalışmanın amacı, öğretmen algılarına göre geçerli ve güvenilir bir ölçme aracı olarak "İdeal Okul Yöneticisi Ölçeği"nin geliştirilmesidir. Bu bağlamda önce ilgili literatür taraması yapılarak madde havuzu oluşturulmuştur. Oluşturulan maddeler akademisyen ve öğretmenlerden alınan görüşler doğrultusunda yeniden düzenlenmiştir. 91 maddelik taslak ölçek ile pilot uygulama yapılmıştır. Açımlayıcı ve doğrulayıcı faktör analizlerinde farklı katılımcı gruplardan veri toplanmıştır. Açımlayıcı faktör analizinde 2021-2022 öğretim yılında Manisa ili Akhisar ilçesinde ilköğretim ve ortaöğretim kademesinde çalışan 302 öğretmenden, doğrulayıcı faktör analizinde ise 261 öğretmenden veri toplanmıştır. Tüm geçerlik ve güvenirlik çalışmalarından sonra ölçeğin üç faktörlü yapıda 39 maddeden oluştuğu gözlenmiştir. Doğrulayıcı faktör analizinden alınan veriler ölçeğin model veri uyumunun kabul edilebilir seviyede olduğunu göstermektedir. Geçerlik ve güvenirlik çalışmalarında elde edilen bulgular ışığında ölçeğin öğretmenlerin ideal okul yöneticisine ilişkin algılarının belirlenmesinde kullanılabilecek geçerli, güvenilir bir ölçme aracı olduğu söylenebilir.

Anahtar Kelimeler: İdeal okul yöneticisi, ideal okul yöneticisi ölçeği, başarılı okul müdürü, ölçek geliştirme.