bluuebunny/crossref_metadata_2025 huggingface dataset:
Impacts of Delays in Project Completion in Terms of Time and Cost
Authors: Daripa Jagannath
Published: July 2022

Abstract: Construction delays can be defined as the late completion of work compared to the planned schedule or contract schedule. Construction delays can be minimized only when their cause are identified. The objective of this study was to identify the major causes of construction delays, the effects of delays, and methods of minimizing construction delays. This study was carried out based on literature review and a questionnaire survey. A total of eight groups were contributed to the cause of construction delays, six factors that effects delays and fifteen methods of minimizing construction delays were identified based on literature review. The questionnaire survey was distributed to the target respondent in UTM construction site. The objectives of the study were successfully achieved. The top three most important factors that contributed to the causes of delays were late in revising and approving design documents, delays in sub-contractors work, and poor communication and coordination change orders by owner during construction. Contractor-related delays was ranked the most significant groups that cause delays, followed by client-related delays, and consultant-related delays. Time and cost overrun were the common effects of delays in construction projects. To minimize delays in construction projects it has been identified that the top three effective methods of minimizing construction delays includes: site management and supervision, effective strategic planning, and clear information and communication channels
Safety at Construction Project: A Review
Authors: Sethi Avishek
Published: July 2022

Abstract: This Paper has been prepared to assist in the importance of safety, their issues and precautions at construction projects like building, road, bridge and sewage etc. The objectives are to describe the processes or stages of safety measures to be followed at a construction project because prevention of accidents is a major aim of construction management, both for human and economic consideration. This safety measures suggest high level protocol at construction project to reducing accident, loss of time, escalation of project cost and loss of reputation of project. The report sought to determine the raw and practical safety issues observed at construction project and how to improve safety at sites so that loss of life, suffering, and damage resulting from avoidable accidents is prevented. In India, construction projects are gradually developing day by day and the fatalities or injures increased day by day according to nature of project so it is important to have an investigation and develop safety plan program.
Microservices Enabled E-Commerce Web Application
Authors: Terdal Dr. Sujata
Published: July 2022

Abstract: Microservices are emerging as a new computing paradigm which is a suitable complementation of cloud computing. Microservices decompose traditional monolithic applications into a set of fine-grained services which can be independently developed, tested and deployed. In this work we have developed an e-commerce web application using microservices architecture. The drawbacks of monolithic architecture are overcome by microservices in building the e-commerce web application. The web application is developed using MERN stack technology. The services developed in the application are containerized using Docker containers. The containerized services are then managed using Kubernetes which is an orchestration platform. Skaffold is used in the application to sync local code files with the cold files in Docker. The events emitted by services are managed using an event bus called NATS streaming server.
An Efficient Book Reading Mechanism using Deep Learning
Authors: Kukreja Anusha
Published: July 2022

Abstract: The importance of reading books and novels has evolved notably with the advancement of information and technology. The relationship among characters in a novel tells an important part of the story. Great novels usually have large and complex character relationship networks due to the number of characters and story complexity. However, with the fast-changing world, people do not get time to read complete books and novels. So, identifying and categorizing the important part of the books, we plan to propose an efficient mechanism based on neural networks, semantic analysis and deep learning which will enable readers to instantly get information about their favourite books.
Blood Classification Technique using Deep Learning
Authors: B Susmitha
Published: July 2022

Abstract: This study aims to develop a system to distinguish blood cells from images. Precise and programmed analysis of blood cell images has been considered as an effective way for the determination of types of blood cells such as Eosinophil, Lymphocyte, Monocyte, Neutrophil. In this work, we extracted different blood cell features such as Eosinophil, Lymphocyte, Monocyte, Neutrophil and then applied convolutional neural network based models for the detection of types of blood cells with photographs involved in structured analysis. It described the innovative solution that provides efficient classification detection and deep learning with convolutional neural networks (CNNs) has achieved great success in the classification of various types of blood cells. A variety of neuron-wise and layer-wise visualization methods were applied using a CNN, trained with a publicly available blood cells given image dataset. So, it observed that neural networks can capture the colors and textures of lesions specific to respective type, which resembles human decision-making. And this model to deploy Django web framework.. We experi
Automatic EV Battery Management and control Systems using IOT
Authors: K Sharan Kumar
Published: July 2022

Abstract: From the statistics, transportation sector contributes over the 50% of the oil consumption and one fourth of the CO2 emissions, which has been considered one of the major factors that leads to Greenhouse effect. By using the Electric vehicles (EVs), the pollution can be reduced and also the dependency on crude oil and also minimizing the transportation related pollutants emission, this regarded as the effective component in the sustainable transportation system and also becoming popular. Here, in this work the proposed design is to create and also handle the electric vehicles (EV) charging and utilization of a vehicle, based on the intelligent process. Because of the electrical power distribution limitation, electric vehicles (EV) charging must be performed in the effective way. This proposed system for Electric Vehicle Charging system and utilization having many advance features. The device will automatically stop the charging and overcharging will not happen in battery. Different parameter will be monitor and based on the parameter battery charging and utilization for load will be control automatically in this implementation.
The Electricity Billing System over IOT
Authors: Lavate Prof. Santosh
Published: July 2022

Abstract: In modern days where the world is technology driven there is a need for an effective electricity metering and billing system. In modern times as well as in future the electronic-meter will play a major role for the power consumption & cost efficient system. The proposed system consists of a Wi-Fi module that enables the project to be more efficient. There is mode selection available on the system. This project is implemented using hardware and Arduino IDE using embedded C language.Their are various advantages that can be stated in this project but the main advantage is that this proposed system will save e electricity Keywords: Atmega 328P, IOT (Wi-Fi module) for communication, Arithmetic Logic Control (ALU), Real Time Clock (RTC), Arduino IDE, embedded C.consumption and due to this the the cost of producing the electricity can also be minimized;
IOT Based Driver Drowsiness Detection and Smart Alerting System
Authors: M. C Akshara
Published: July 2022

Abstract: Generally, road accidents caused by a fatigue driver is a very serious problem causing in thousands of road accidents each year. According to the National Highway Traffic Safety Administration, every year about 1,00,000 police reported crashes involve drowsy driving. Drowsiness is one of the main causes of accidents alongside with other cases such as drunk driving, distractions, and so on. A way to overcome this issue would be with the use of sensors. They can detect, alert and can potentially save a person’s life. For drowsiness detection, there are certain bio-indicators that can detect the driver’s face for any signs of drowsiness and can alert them before anything harmful could happen. The buzzer will be activated if the driver’s eye-blink and the health parameters are found abnormal.
Examining Seismic Response for Rigid Building Frame Having Composite Column
Authors: Swarnkar Jagriti
Published: July 2022

Abstract: Concrete filled steel tubes are generally used in Beams, Columns, Piers and caissons for deep foundations. The steel tube functions as the formwork for casting the concrete and hence, construction cost is reduced. The prime focus of the present work is to study the behavior of RCC structure under the effect of seismic loads provided with composite columns. This research study comprises of seismic analysis with the design of rigid frame with Reinforced Concrete column, Concrete encased steel and steel tube encasing concrete columns. These cases are designed based on IS 1893:2016 using ETABS software. The result shows that steel encased concrete is performing better than conventional column. The construction practices is the only difficulty arises in such of composite column.
Result Analysis of User Review for Sentiment Classification
Authors: Bhende Miss. Rutuja P.
Published: July 2022

Abstract: Analysis of Sentiment is one of the fastest growing fields with its demand and potential benefits that are increasing each and every day. Analysis of Sentiment aims to classify the polarity of a document by using the natural language processing, text analysis. by using of internet and modern technology, there has been a lot of growth in theamount of data. Each and every individual is in position to precise his/her own ideas freely on social media. Every data canbe analyzed and used in order to draw benefits and quality information. In this paper, the focus is on cyber-hate classification based on for public opinion or views, since the spread of hate speech using social media can have disruptive impacts on social sentiment analysis. In recent , here proposing a modified approach with two stage training for dealing with text ambiguity and classifying three type approach positive, negative and neutral sentiment, and compare its performance with those popular methods and also some existing fuzzy approaches. After that comparing to the performance of proposed work with commonly used sentiment classifiers which are known to perform well in this task. The results indicate that our modified approach performs marginally better than the other algorithms
Arduino Based Smart and Remote Voting System with Smart Card Implementation and Dual Biometric Authentication
Authors: H P Suraj
Published: July 2022

Abstract: Democracy is a synonym for progress of the nation. Improving voting numbers will boost in overall development of the country. To achieve this task, we propose an IoT based remote electronic voting system, provided with dual biometric authentication, composed of fingerprint verification and face recognition. Instead of paper based identification card, we intent to implement an RFID based smartcard with details of the voter stored in the card, including biometric data saved alongside information like name, age, locality, constituency and even aadhar identification number. This model uses face recognition using Haar cascade and LBPH algorithms, set up using OpenCV libraries. The EVM system captures the face data of the voter, verifies by comparing it with existing face datasets, and upon validation will be allowed to cast their vote.
Pharmacological activity of sea cucumber Cucumaria frontosa derived amylase enzyme against blood stream pathogen
Authors: Vijayalakshmi S. , Mohankumar A.
Published: July 2022

At presently availability of resistance pathogen to numerous drugs is a common feature of hospital-acquired Pseudomonas aeruginosa strains. So, the present study collect the 80 blood sample from blood cancer patient in Revathi Medical Hospital, Tirupur City for isolating the PA strain from blood sample and confirmed the bacterial strain using standard test method followed by drug susceptibility test for identification of resistant’s. In this study the maximum resistant was recorded in antibiotics Vancomycin 99% and maximum sensitive was observed in antibiotic Levofloxacin 99%. The blood stream infection causing PA plasmid extracted in 19 carcinogenic isolates which was showed more than 50% resistance selected for plasmid isolation. Due to the ability of resistant mechanism present in BSI pathogen the identification of new resources for novel antibiotics used urgently need to carry out a specific task to deal the blood stream infection. Moreover the enzyme especially the amylase have been isolated and purified from marine sea cucumber associated microorganism and the antimicrobial assay was done by using well techniques. The maximum zone of inhibition at 50, 100 and 150µl (, 25mm, 26mm and 16mm, 22mm, 23mm) of amylase extract was observed in the PAVG43,60 isolates. So hence this motto of this research proved the sea cucumber associated extracted amylase enzyme play a major role in the diagnosis of blood stream infection in cancer patients.

Keywords: Blood Stream Infection, Pseudomonas aeruginosa, Sea Cucumber, Amylase
Development of Oro-Dispersible Tablet of Meclizine by Using Different Superdisintegrating Agents
Authors: Kumar Anubhav , Jain Ashish , Yadav Pradeep Kumar , Singhai Akhlesh Kumar
Published: July 2022

The proposed study is development of oro-dispersible tablet containing meclizine hydrochloride solid dispersion (FMODDs) formulation with using natural superdisintegrant with direct compression. The superdisintegrants and its concentration shall be during the preparation of FMODDs with meclizine hydrochloride by using direct compression via employing different excipients in different ratio including: superdisintegrants {sodium starch glycolate (SSG), Ac-Di-Sol, crosspovidone (CP), Spray dried lactose and microcrystalline cellulose (MCC)} which were used alone and in various combination and mannitol, along with lubricant and glidants. The object of proposed work was preparation of FMODDs with a short disintegration time, sufficient mechanical strength, better patient compliance, and acceptable stability profile by employing different methods of preparation and studying different variables affecting pre and post-compression parameters of formulas of meclizine hydrochloride. The combination of agents have more disintegrating property due to rapid water uptake and dispersion time which lead to rapid release of drug and made the dissolution faster. The results of the release kinetics study showed that all the formulations obeyed first order drug release profile more closely, i.e., the release rate depended upon the initial concentration of drug.

Keywords: Solid dispersion, Oro-dispersible, Fast disintegration, Direct compressed tablet, Meclizine hydrochloride, Superdisintegranting agents
Formulation and evaluation of exfoliating facial scrub containing avocado and almond extract
Authors: Bhise Mrinal Pramod , Dakare Amol Ashok , Bondre Kalyani Nandkumar , Bhosale Karan Somnath , Chile Omkar Prabhakar , Mane Rohan V.
Published: July 2022

Major objective of present study to be prepared a herbo-mineral facial scrub. Majorly facial skin comes in contact with dirt, pollution, dust particles having large number of dead cells. In order to remove dead cells and make skin healthy, clean, nourished some facial preparation are required. Prepared scrub contains various natural ingredients which are safer for use having fewer side effects. Also they possess antioxidant, anti-aging, humectant properties 1 .This exfoliating facial scrub is prepared by using simple mixing method using various ingredients such as avocado extract, coffee beans, almond oil, carbapol 934, hyaluronic acid, preservatives and perfuming agents also added to this preparation with homogenous mixing. Evaluation of this exfoliating facial scrub includes physical appearance, texture, odour, colour, viscosity, Spreadability and washability. Prepared formulation can be used effectively as it shows good exfoliating property, good scrubbing property. It can be used to make exfoliate, healthy, glowing skin.

Keywords: Exfoliating facial scrub, less side effect, good scrubbing property, glowing skin.
Silver Sulfadiazine: Action on Burn Wound Sepsis and Infections
Authors: Walia Satwinder Singh , Prasad D.N.
Published: July 2022

The purpose of this systematic review and meta-review has shifted from assessing the consequences of silver sulfadiazine with most different drugs (SSD) for burn recovery and contamination prevention to different novel dressings, without or with silver. Burn units have to be able to better control sepsis. The degree to which a burn topical antibacterial agent is absorbed determines its effectiveness. Absorption of a topical antibacterial agent may be evaluated against the absorption of a test solute in isolated preparation of the stratum corneum in a cell in an in vitro model. Despite the fact that adding silver sulfadiazine (AgSu) to pure deoxyribonucleic acid (DNA) resulted in the formation of silver sulfadiazine (AgSu)the formation of AgSu-DNA complexes, no such complexes were detected in bacteria treated with AgSu. In treated bacteria, AgSu inhibited macromolecular syntheses as DNA synthesis was slightly more sensitive. A tiny amount of sulfadiazine appears to be active in this situation. Pediatric patients were randomly assigned to treatment with either Silva-Sorb® Gel or Silvadene® silver sulfadiazine cream for up to 21 days or to the point of full reepithelialization of the wound.

Keyword: Silver, Sulfadiazine, Silvasorb, Bacteria, Burn, Wound.
Tumor Biology; Usefulness of Thermosensitive and pH Sensitive Polymeric Nanoparticles for Tumor Targeting: A Review
Authors: Banda Srikanth
Published: July 2022

Polymeric nanoparticles (PNPs) have attracted the interest of many scientists and have been utilized in an increasing number of fields during the last two decades. The conventional chemotherapeutic agents have poor pharmacokinetic parameters such as non-specific distribution of drugs, the lack of drug specific affinity towards a pathological site, and thus necessitating large dose of a drug to achieve high local concentration in the body leading to systemic toxicity associated with serious side effects. A thorough and precise understanding of tumor microenvironment such as angiogenesis, tumor pH, enhanced permeation and retention (EPR) effect, abnormal lymphatics, multidrug resistance (MDR) and high interstitial fluid pressure, allows designing drug delivery systems that specifically target anti-cancer drugs to tumors. An attempt has been made in this article to highlight the temperature and pH sensitive PNPs, and PNPs with dual and double response to both temperature and pH that have a distinct capacity to target tumors with limited effect on healthy tissues. The stimuli responsive nanoparticles are classified based on their mechanism of response to temperature and pH. Structure of the polymer, methods of drug loading, and characterization of PNPs are elucidated.

Keywords: Polymeric nanoparticles; pH sensitive polymers; Thermosensitive polymers; Tumor microenvironment; Multidrug resistance; Drug loading.
A review on Advanced approaches and polymers used in gastroretentive drug delivery systems
Authors: Varshi Reena , Jain Vikas , Pal Pradeep
Published: July 2022

Insufficient pharmacokinetic characteristics may be associated with the widespread use of oral dosage forms in the treatment of disease. In some cases, the drug is barely soluble; in others, the formulation's rapid transit through the gastrointestinal tract (GIT) makes it difficult to achieve therapeutic levels in body; in addition, some drugs must act locally due to a gastric pathology, but they remain in the stomach for only a short time. Numerous studies have focused on the development of formulations that are capable of enhancing all of these characteristics and extending the stomach residence duration. The prolonged stomach retention duration afforded by gastroretentive controlled drug delivery devices increases the therapeutic efficacy of many orally administered drugs. In the present investigation, we reviewed the advanced methods and polymers used to develop effective gastroretentive drug delivery systems. These methods include swelling and expansion, mucoadhesive, high density, low density, ion exchange, raft forming, magnetic, and floating drug delivery systems. The development of gastroretentive devices involves a broad array of polymeric materials. This work intends to expedite the development of innovative methods by offering a comprehensive understanding of unique gastroretentive approaches along with the polymeric materials utilised in the fabrication of gastroretentive drug delivery systems for oral drug delivery.

Keywords: Gastroretentive; mucoadhesive; floating; raft forming system; mucoadhesive; swellable.
Preparation of Luliconazole loaded silver nanoparticles Topical gel
Authors: Kumar Ajay , Soni Abhishek , Kumar Ashish , Yashpal , , Devi Jyoti
Published: July 2022

After optimization of the luliconazole loaded silver nanoparticles formulation it was given a gel base for topical delivery the silver nanoparticles have a very low viscosity. The gel was formed by varying the concentration of carbopol 940 as 0.75%, 1. %, 2%. The optimized luliconazole loaded silver nanoparticles formulation LSN14 was incorporated into different concentration carbopol gel base of different concentrations of carbopol and evaluated for various in vitro characterization parameters homogeneity, grittiness, measurement of pH, drug content, viscosity study, Spreadibility, in - vitro drug release studies and drug release kinetics. All prepared gel formulation having different concentration of carbopol was homogenous and uniform in appearance and free from grittiness except the formulation LSN14G1Have not sufficient thickness and thus it was not used further evaluation. On the basis of result of above parameters LSN14G3 was selected for further in-vitro drug release study. Comparison of In vitro Percentage drug release study of Control gel of Luliconazole and luliconazole loaded silver nanoparticle gel formulations LSN14G3 and in - vitro drug release profile the Percentage drug release of prepared silver nanoparticle gel was found to be higher in sustained manner93.36±0.56 after 24 hr as compare to control gel 38.50±1.21.

Keywords: optimization, silver-nanoparticles, carbopol, kinetics, luliconazole
Highly Promising an Anti-Cancer Drugs : Metal Complex Bearing Sulfur Chelating Ligand, A Hypothetical Design
Authors: Sarkar Sanchita , Sarkar Shuranjan , Ahmed Zakaria
Published: July 2022

In anticancer chemotherapy, drug targeting and delivery methods depend on agents with selective access to cancer cells to deliver drugs to the target, and approaches to finding such agents often depend on novel design strategies employing bioactive vectors. Platinum-based complexes are extremely important drugs for the treatment of cancer. Recently synthesized complexes of Pt (IV) have been shown to have several advantages, such as they are safer, can be used orally, are highly anti-cancer effective, there is no cross-resistance to cisplatin, and their effectiveness is compared with commonly used Pt (II) compounds such as cisplatin and oxaliplatin. A molecular mimicry model for the generation of new active drugs may be synthesized by the 3,5-ditert-butyl-2-hydroxy-benzylaminocysteine (DTHBAC) where a cysteine group and two tertiary butyl groups attached to the phenol aromatic ring can be coordinated with platinum. This appropriate ligand with the platinum complex is fit for the anticancer drug. Based on the present modeling, it can be recommended in the management of patients, and from this perspective, the status of the platinum anticancer drug field will develop over the next decade. Moreover, the authors have no doubt that this will benefit patients in the future and will be widely used in cancer treatment for years to come.

Keywords: Drug design, Anti-cancer, Cisplatin, Complex, Chelate.
An Overview on Dementia: A Major Symptom of Alzheimer's Disease
Authors: Kaur Jaspreet , Melkani Indu , Singh Ajeet Pal , Singh Amar Pal , Bala Kiran
Published: July 2022

Dementia is a word for an acquired illness in which two or more cognitive abilities are lost due to a brain disease or injury. The most common form of dementia is Alzheimer's type dementia (DAT). It has been associated to cerebral cortical degenerative anomalies. It's also visible in neurologic diseases that primarily affect subcortical systems such as the basal ganglia and brain stem. The causes are plaques of β-amyloid and tangles of intraneuronal tau protein. Dementia is addressed in this overview. Pathophysiology, epidemiology, and different varieties of dementia; contributing factors to dementia; symptoms, causes, diagnosis, prevention, and care; and new breakthroughs in dementia treatment. It also looks at how patients with mental problems coped during the COVID-19 outbreak. Patients may require more therapies to manage their illness, and some future drugs are now being explored.

Keywords: Dementia, Alzheimer's, Plaques, Cognitive training, β-amyloid
Traditional uses, Pharmacology and Phytochemistry of National flower of Nepal Rhododendron arboreum: A Review
Authors: Ahmad Md. Parwez , Ali Sheeza , Wahab Shadma , Perween Tarannum , Shahzad Naiyer , Dhami Dabal Bahadur
Published: July 2022

Methods: This review provides scientific grounds in the literature for the phytochemical and pharmacological activities of Rhododendron arboreum, from 2010- 2021. Chiefly three bibliographic databases were used as the main sources of information (Google scholar, PubMed, and Science Direct). The keywords used in this research are as follows: “Phytochemical”, “National flower”, “Bioactive compounds”, “Pharmacology” and “Rhododendron arboreum”.

Results: Various studies were included in this review according to the required criteria, including phytochemical and traditional uses. Rhododendron arboreum contains flavonoids alkaloids, terpenoids, glycosides, steroids, anthraquinones, saponins and tannins. Pharmacological and traditional uses of this plant on the basis of presence of above active ingredients.

Keywords: Bioactive compounds, National flower, Rhododendron arboreum
Formulation and Evaluation of Patch Preparations for Respiratory Relief from a Blend of Extracts and Essential Oils of Ginger Rhizome
Authors: Astuti Ratnaningsih Dewi , Simamora Sarmalina , Tedi , , Taswin Muhamad
Published: July 2022

In this study, pharmaceutical preparations for respiratory tablets in the form of patches have been developed, which are used by placing them on the skin, clothes or masks associated with the user. A patch formula containing a mixture of 3% ginger extract and ginger essential oil was created at 0.1%, 0.2% and 0.3%, respectively, with variations of PVA and PVP as polymers to control the release of ginger essential oil as a breathing reliever. Each preparation with ginger essential oil content used PVA and PVP with variations of 1:1, 1:1.5 and 1:2. The practices were evaluated for 21 days on days 0, 7, 14, and 21. TAfter obtaining long-lasting results, an irritation test was carried out on the respondents. The results showed that during storage for 21 days, the pH was in the range of 5.14-6.11, weight uniformity ranged from 1.24 g-1.65 g, humidity 7.18%-8.88%, and folding endurance >300 times. The variation of PVA and PVP shows that the higher the PVP content, the weight of the patch increases and the humidity decreases. So it can be concluded that a good formula is a formula with variations of PVA and PVP 1: 1.5 and ginger essential oil content of 0.3%. After obtaining long-lasting results, an irritation test was carried out on the respondents. The results showed that during storage for 21 days, the pH was in the range of 5.14-6.11, weight uniformity ranged from 1.24 g-1.65 g, humidity 7.18%-8.88%, and folding endurance >300 times. These alterations, do not change color and odor nor irritate the respiratory tract. The variation of PVA and PVP shows that the higher the PVP content, the weight of the patch increases, and the humidity decreases. So it can be concluded that a good formula is a formula with variations of PVA and PVP 1: 1.5 and ginger essential oil content of 0.3%; the weight of the patch increases, and the humidity decreases. So it can be concluded that a good formula is a formula with variations of PVA and PVP 1: 1.5 and ginger essential oil content of 0.3%.
Review: The Effectiveness of Using Vitamins in Pregnant Women as Prevention of Pre-eclampsia
Authors: Kamri Andi Maulana , Kosman Rachmat , Putra Bayu
Published: July 2022

Nutrients needed by pregnant women are high. The variety of vitamins consumed early in pregnancy can affect the condition and growth and development of the baby and the health of pregnant women. The incidence of pre-eclampsia is one of the things that most often appears in pregnant women who are at risk for mothers and newborns. This study will look at vitamins that play an important role in preventing the occurrence of pre-eclampsia. The study used the PICO method in search and assessment of 13 articles obtained from the PubMed and Research Gate databases. Some of the vitamins needed by pregnant women include calcium, folic acid, iron, mecobalamin, zinc, vitamins A, E, and pyridoxine. All vitamins have a positive effect on pregnant women in supporting growth and also maintaining the health of pregnant women. Folic acid and calcium play an important role in maintaining blood pressure. This is related to the presence of homocysteine ​​and endothelial dysfunction that occurs in the first and second trimesters. Zinc itself has a role in maintaining mental health which usually occurs due to premenstrual syndrome and also pregnancy in the early trimester. This is because of blood pressure disorders due to mental health. However, there is nothing that shows a relationship with the incidence of pre-eclampsia. The most important vitamins for maintaining blood pressure during pregnancy are folic acid and calcium.

Keywords: Vitamins, Pregnant, Pre-eclampsia, Preterm Birth, Effectiveness.
Therapeutic potential of Murmakki (Commiphora myrrha) in gynaecological disorder: A Unani review
Authors: Shazamani S , Begum Wajeeha , Sumaiya Syeda
Published: July 2022

Murmakki is a well-known and potent herbal drug used in various traditional medicines for its various beneficial effects on different Gynaecological ailments and diseases. It is commonly known as Gum Resin. It Consists of oleogum resin obtained by exudation from the stem of a plant of Commiphora myrrha. It is used in Saudi Arabia, Indian and Western Medicine and is listed in the British pharmacopoeia as an antispasmodic and expectorant. In ancient traditional Persian manuscripts, it has been noted that myrhh acts as a uterine stimulant and probably cause complete abortion. In Unani Medicine, it is used as a potent drug for dysmenorrhea and amenorrhea as mentioned by Avicenna and Razi in their treatises. This review article discusses the pharmacognosy, phytotherapy, phytochemical and biological studies of Commiphora myrrha along with a comprehensive review based on Unani Medicine.

Keywords: Murmakki, Commiphora myrrha, Oleo gum resin, Gynaecological disorders.
The Chemical and Pharmacological Advancements of Quinoline: A Mini Review
Authors: Bharti Anurag , BIJAULIYA ROHIT KUMAR , Yadav Anita , Suman ,
Published: July 2022

Quinoline is a preferred scaffold that emerges as a prominent assembly motif for the creation of novel pharmacological molecules among heterocyclic compounds. An important family of chemicals includes quinoline and its derivatives that have been studied for various biological activities. Due to its wide range of bioactivity, quinoline, which is made up of benzene fused with N-heterocyclic pyridine, has drawn a lot of interest as a key template in drug creation. In order to demonstrate the quinoline motifs' significant efficacies for upcoming drug development, this review intends to provide the most current developments in chemistry, their medicinal potential, and their pharmacological applications. As a result, these compounds have been produced by several scientific groups as intentional structures, and their biological functions have been examined. The current study offers succinct information on quinoline's natural sources, as well as details on newly marketed medications that include quinoline. The pharmacological effects of quinoline derivatives, such as their anticonvulsant, antibacterial, antiviral, anti-protozoal, antimalarial, anticancer, anti-inflammatory, and anthelmintic properties, are also discussed in this study.

Keywords: Nitrogen-Based Heterocycles, Quinoline, Synthesis, Biological Activities
Assessing service providers’ satisfaction with the chronic diseases package provided through the National Health Insurance Fund in Sudan
Authors: Fakihammed Wael A. , Hussien Rehab A. , Atbara Zohal B. Ahmed , Higaz Shiraz O. , Mirghani Ashwag A. , Elkhatim Osama E. Sir , Abdalla Moneer A. , Hammad Almoeiz Yousif
Published: July 2022

Background: The prevalence and burden of chronic diseases is growing significantly with direct impact on health and financial security of population. In Sudan, there is a continuous effort to improve access for good and integrated health services but still the utilization of these services is low. Therefore, there is an urgent need to assess the availability and integration of benefit package to ensure better and effective coverage of services.Aim: This is a descriptive cross sectional based study aimed to assess the opinion of service providers about the chronic diseases package provided through the national health insurance fund.Methods: Form390 participating, data was collected via closed ended standardized questionnaires. Pre testing was done to ensure quality survey instruments and fieldwork procedures were conducted. A structured questionnaire with closed-ended questions was developed based on literature and previous studies. The questionnaire made up of 30 questions and organized in the following sections: background characteristics, medical characteristics, health professionals’ knowledge and practice related to NHIF ’chronic diseases package and perception about NHIF ‘chronic diseases package.Results: Our results showed that despite the existence of a number of issues, the National Health Insurance Fund is rather accepted amongst our respondents. Issues manifested were in regards to health education and supply issues of drugs. Conclusion: Our study concluded that, there is an obvious weakness in both training of providers and implementation of national protocols for chronic diseases. Moreover, despite the challenges of drug availability, 70% of our participants expressed positivity when questioned about the presentation of the drug package, bearing in mind the importance of reviewing the list to ensure its inclusion of new items. There is a need for training medical providers about chronic diseases with more focusing on health promotion and application of national guidelines. Additionally, integration of chronic diseases services in necessary for achieving universal health coverage.

Keywords: national protocols for chronic diseases, national health insurance fund, health promotion
Evaluation of Prescription Pattern and Medication Adherence in Patients with Alcoholic Liver Disease
Authors: ANIL GOPIKA T , MS Gowri Sivan , SAJIKUMAR HARIPRIYA , S HONEY P , RB Mahendra , Nyamagoud Sanat B
Published: July 2022

Background: ALD is the most common cause of morbidity and mortality among patients. A patient’s Medication Non-Adherence may also interfere with the progression of Disease. Analysis of Prescription pattern in ALD helps to ensure the safety of the Patient by assessing the signs and symptoms of disease and its appropriate therapy.  Thus, educating the patients regarding their clinical condition will have a significant role in reducing the severity of the disease. Aim: To assess the Prescription pattern, Medication Adherence and to identify the correlation between the medication adherence and the educational status in ALD patients. Materials and Methods: The Study was a Prospective Observational study carried out for a duration of Six months. Morisky Green Levine scale was the tool used to assess the medication adherence. Data was collected using a self-designed data collection form. Results: A Total of 160 Alcoholic subjects were assessed during the study period among which 65.62% of them were illiterate. Out of total cases 76.87 % of hepatoprotective drugs, 50.62% antiemetics, 38% vitamins and 11% of anti-ulcer drugs were prescribed among patients.  It was found that there exist a relationship between educational status and medication adherence (P-value: 0.0021). Conclusion: The study helped to assess the  different class of drugs, drugs used in different comorbid conditions and also to evaluate, identify and solve the problems associated with the Medication Non-Adherence of the patients.

Keywords: Medication Adherence, Alcoholic Liver Disease, Rational Drug Therapy.
Baby Massage Video to Increase Knowledge, Motivation and Behavior of Postpartum Mothers
Authors: Rasumawati Rasumawati , Puspita Erlin , Herlina Nina , Ekowati Erik
Published: July 2022

Massage is a tactile stimulation that provides benefits in accelerating the process of growth and development of the baby if it is done regularly and appropriately. There is an increase in knowledge about baby massage in postpartum mothers, it will be motivated to do baby massage correctly. The purpose of this research is to find out effectiveness of baby massage video on knowledge, motivation, and behavior of postpartum mothers at the clinic of Anny Rahardjo in 2021. This type of research uses Quasi experimental with pretest-posttest design with control group. The population in this study were 60 postpartum mothers who visited the Clinic Anny Rahardjo, East Jakarta during the month of June to August 2021by method Purposive Sampling. Collecting data using a questionnaire given before and after the intervention, then analyzed by Mann Whitney and test Wilcoxon. The results showed that there was no difference in the average between the two control groups and the treatment group before the study (pretest) on the knowledge variable with p-value =0.521, Motivation p-value = 0.282, and behavior p-value = 0.107. After the treatment group received an intervention in the form of giving a baby massage video, there was a difference in average (posttest) in the treatment and control groups on the variables of knowledge, motivation and behavior with p-value = 0.000. Giving baby massage videos can be used as a medium for delivering information in the form of images and sounds that are easy to remember and understand by postpartum mothers.
How is the practice of nurses in preventing infection of central venous catheters in hospitalized patients?-Nurse knowledge and attitudes
Authors: Manurung Santa , Dewi Yupita
Published: July 2022

Central venous catheter (CVC) is an action that is often performed in treatment. There are several indications for the installation of a central venous catheter, ranging from measurement of central venous pressure (CVP), chemotherapy to parenteral nutrition. Central venous catheter wound care that is not carried out according to the procedure can cause various complications, one of which is infection. The incidence of sepsis due to central venous catheter placement is a significant cause of morbidity and mortality for patients. All nurses are required to have good skills and attitudes in the practice of implementing central venous catheter wound care in accordance with the procedure. Objective: This study aims to analyze the relationship between knowledge and attitudes of nurses regarding wound care to nurses practice in preventing wound infections in patients with central venous catheters. Methods: The design of this study was cross sectional using a descriptive correlational design. This research was conducted in July 2020. The number of samples involved in this study were 69 nurses with Diploma III educational qualifications in the inpatient ward of Dharmais Cancer Hospital. Data analysis using chi-square. Results: Bivariate analysis showed a value of p<0.05 for nurses knowledge and attitudes regarding central venous catheter wound care on nurse practice in preventing central venous catheter infection. Conclusion: there is a relationship between the level of knowledge and attitudes of nurses in wound care to the practice of nurses in preventing wound infections in patients with central venous catheters in hospital inpatient rooms.

Keywords: Nursing knowledge, attitude, practice, infection prevention, central venous catheter.
Formulation of stick laor (Eunice viridis) as an alternative food supplement for toddlers in stunting prevention
Authors: Ristanti Ety Yuni , Asrar Muhammad
Published: July 2022

Adequate nutrition is needed as the basic capital of the child's growth and development process, especially protein. The occurrence of malnutrition conditions will affect the achievement of perfect growth. Based on this phenomenon, it is necessary to fulfill nutritional needs, especially the consumption of foods rich in energy and protein as well as micronutrients. Local food sources of energy and protein produced from Maluku Province are enbal, laor and moringa leaves. Laor (Eunice viridis) contains 29.8% protein, contains essential and non-essential amino acids, 229.26 mg calcium, 2.439 mg zinc and 3.149 mg iron per 100 grams of laor flour. The purpose of this study was to analyze the Physicochemical and sensory evaluation of stick laor (eunice viridis) as an alternative food supplement for toddlers in stunting prevention. The research method used in the first year of research was a RAL experimental design (Completely Randomized Design) which consisted of four treatments, namely the difference in comparison with the use of 5% laor flour was coded F1, for the use of 10% laor flour was coded F2 and the use of 15% laor flour coded F3. The variables measured were levels of protein, fat, carbohydrates, energy, zinc, Fe, calcium. Organoleptic test for taste, aroma, color and texture. The results showed that the highest content of energy, protein, fat, calcium, iron and zinc was F3, F2 had the best acceptability in terms of color, taste, aroma and texture. Sticks Laor increase the intake of energy, protein, and calcium for toddlers and increase serum calcium levels.

 Keywords: Sticks laor, food supplement, toddlers, stunting prevention
Use of Telemedicine in the Family Medicine Clerkship: A CERA Study
Authors: Everard Kelly  M. , Schiel Kimberly S. , Xu Evan , Kulshreshtha Ambar
Published: July 2022

Background: In March 2020 with the onset of the COVID-19 pandemic, clinical rotations abruptly ceased, and telemedicine became an alternative to in-person patient care. This study investigates factors associated with long-term adoption of telemedicine during family medicine clerkships.
Methods: Data were gathered from the 2021 CERA survey of family medicine clerkship directors. Participants answered questions about the use of telemedicine in the clerkship, adequacy of telemedicine resources, how well telemedicine visits helped students meet course objectives, quality of course evaluations, efficiency of students seeing patients using telemedicine, and likelihood of continuing use of telemedicine once in-person visits are reinstated.
Results: The response rate was 48.8%. While most clerkship directors did not use telemedicine prior to the COVID-19 pandemic with their own patients, most had medical students utilize telemedicine during the pandemic. Clerkship directors were more likely to continue having students use telemedicine in the clerkship if it helped them meet clerkship objectives, if telemedicine visits were efficient, and if course evaluations were positive. Adequacy of resources was not associated with likelihood of retaining telemedicine in the clerkship.
Conclusions: Family medicine clerkship directors will likely continue to have students see patients via telemedicine, particularly if feedback is positive. Family medicine educators need to develop and evaluate new telemedicine curriculum for learner benefit, patient acceptability, and overall care quality.
A case of type 2 diabetes mellitus leading to euglycemic diabetic ketoacidosis in 3 days after starting sodium-glucose cotransporter 2 inhibitor while on a very-low-carbohydrate diet
Authors: Inoue Ayumi , Katayama Akihiro , Sue Mihiro , Hasegawa Momoka , Maeda Megumi , Matoba Masaki , Ishii Takahiro , Kuribayashi Remi , Tenta Masafumi , Matsushita Yuichi , Takeda Masaya , Iseda Izumi , Wakatsuki Toshiyuki , Hida Kazuyuki
Published: July 2022

This paper presents a case with type 2 diabetes mellitus on a very
low-carbohydrate diet who developed euglycemic diabetic ketoacidosis
(EDKA) 3 days after starting sodium-glucose cotransporter 2 inhibitors
(SGLT2i). When initiating SGLT2i, healthcare providers should confirm
the implementation of a low-carbohydrate diet and provide intensive
guidance to prevent EDKA.
Rabies encephalitis in Mauritania
Authors: Boushab Boushab Mohamed , Hacen Ahmed Benane , El-Wafi Baba Sidi , Basco Leonardo Kishi
Published: July 2022

From 2016 to 2021, two cases of rabies encephalitis were diagnosed and
hospitalized at the Kiffa hospital center. Neither of them had started
the rabies vaccination after the dog bites before symptoms appeared. In
countries where rabies still occurs, health workers should be trained
for an efficient management of dog.
Unimpaired neurodevelopmental outcome in one year old borderline viable twins born at 22 weeks gestation: A Case Report
Authors: Alrawi Wafaa , Atrak Taisser , Abuobayda Ashraf , Elmansoury Nabil , Elnakeib Omer , Lonikar Abhijeet
Published: July 2022

Infants born at 22–23 weeks rarely survive, and most develop severe
complications, especially in the case of multiple births. This age is
considered the threshold for active intervention. We report the survival
of twins born at 22 2/7 weeks gestation. Recently, advances in neonatal
care have improved infant survival.
Metal Oxide nanostructures-based Gas Sensors
Authors: Goel Neeraj , Kunal Kishor , Kushwaha Aditya , Kumar Mahesh
Published: July 2022

The usage of the gas sensor has been increasing very rapidly in the
industry and in daily life for various potential applications. In recent
years, metal oxide semiconductors (MOS) become the primary choice for
designing highly sensitive, stable, and low-cost real-life
applications-based gas sensors due to their inherent physical and
chemical properties. Researchers have proposed numerous sensing
mechanism to explain the functionality of MOS based gas sensors. In this
review, we have comprehensively covered different sensing mechanisms
used for MOS. We have also discussed different parameters affecting the
sensitivity and selectivity of the gas sensors. Moreover, the different
techniques used to enhance the gas sensing response of MOS based sensors
are also extensively covered. And finally, we give our prospective on
recent opportunities and challenges on future applications of MOS based
gas sensors.