bluuebunny/crossref_metadata_2025 huggingface dataset:
Nuclear Physics and Astrophysics Constraints on the High Density Matter Equation of State
Authors: Stone Jirina R.
Published: July 2021

(1) This review has been written in memory of Steven Moszkowski who unexpectedly passed away in December 2020. It has been inspired by our many years of discussions. Steven’s enthusiasm, drive and determination to understand atomic nuclei in simple terms of basic laws of physics was infectious. He sought the fundamental origin of nuclear forces in free space, and their saturation and modification in nuclear medium. His untimely departure left our job unfinished but his legacy lives on. (2) Focusing on the nuclear force acting in nuclear matter of astrophysical interest and its equation of state (EoS), we take several typical snapshots of evolution of the theory of nuclear forces. We start from original ideas in the 1930s moving through to its overwhelming diversity today. The development is supported by modern observational and terrestrial data and their inference in the multimessenger era, as well as by novel mathematical techniques and computer power. (3) We find that, despite the admirable effort both in theory and measurement, we are facing multiple models dependent on a large number of variable correlated parameters which cannot be constrained by data, which are not yet accurate, nor sensitive enough, to identify the theory closest to reality. The role of microphysics in the theories is severely limited or neglected, mostly deemed to be too difficult to tackle. (4) Taking the EoS of high-density matter as an example, we propose to develop models, based, as much as currently possible, on the microphysics of the nuclear force, with a minimal set of parameters, chosen under clear physical guidance. Still somewhat phenomenological, such models could pave the way to realistic predictions, not tracing the measurement, but leading it.
Variations in Energetic Particle Fluxes around Significant Geomagnetic Storms Observed by the Low-Altitude DEMETER Spacecraft
Authors: Gohl Stefan , Němec František , Parrot Michel
Published: July 2021

A superposed epoch analysis is conducted for five geomagnetic storms in the years 2005 and 2006 with the aim to understand energetic particle flux variations as a function of L-shell, energy and time from the Dst minimum. Data measured by the low-altitude DEMETER spacecraft were used for this purpose. The storms were identified by a Dst index below −100 nT, as well as their being isolated events in a seven-day time window. It is shown that they can be categorized into two types. The first type shows significant variations in the energetic particle fluxes around the Dst minimum and increased fluxes at high energies (>1.5 MeV), while the second type only shows increased fluxes around the Dst minimum without the increased fluxes at high energies. The first type of storm is related to more drastic but shorter-lasting changes in the solar wind parameters than the second type. One storm does not fit either category, exhibiting features from both storm types. Additionally, we investigate whether the impenetrable barrier for ultra-relativistic electrons also holds in extreme geomagnetic conditions. For the highest analyzed energies, the obtained barrier L-shells do not go below 2.6, consistent with previous findings.
“What Do Our Boys Know about Sex?” Preliminary Data of a New Questionnaire for the Evaluation of the Knowledge of Sexuality among Adolescents
Authors: Persico Francesco , Fedelini Paolo , Fabiano Marco , Pucci Luigi , Ferraiuolo Maria , Giannella Riccardo , Carrino Maurizio , Chiancone Francesco
Published: July 2021

Background: The sexual health of young people is an especially important issue for national health policies. Adolescents, in fact, are at elevated risk for adverse sexual and reproductive health outcomes relative to their habits, sexually transmitted infections (STIs), sexual behaviour and teenage pregnancy. The aim of this study was to assess the knowledge about sexuality of students under the age of 18. Moreover, we aimed to explore the influence of sex education on sexual knowledge and behaviour. Methods: The participants were enrolled during a cultural exchange project in September 2019. After completing the questionnaire, all students took part in a sex education course performed by an urologist with expertise in sociology and psychology. The adolescents repeated the same survey in a web form in September 2020, one year after the course. Results: Analyzing the data, sex education lessons helped to improve students’ confidence in approaching all the issues of the questionnaire. Moreover, we observed a significant increase in the role of school as main source of information, while the role of the internet, media and family remained stable. Conclusions: This study encouraged the introduction of school-based sexual education policies, pointing to opportunities for structural early intervention programs.
Peptide Inhibitor of Complement C1, RLS-0071, Reduces Zosteriform Spread of Herpes Simplex Virus Type 1 Skin Infection and Promotes Survival in Infected Mice
Authors: Bhutta Maimoona , Sausen Daniel , Reed Kirstin , Gallo Elisa , Hair Pamela , Lassiter Brittany , Krishna Neel , Cunnion Kenji , Borenstein Ronen
Published: July 2021

Herpes simplex virus type 1 (HSV-1) is a prevalent human pathogen primarily transmitted through skin-to-skin contact, especially on and around mucosal surfaces where there is contact with contaminated saliva during periods of viral shedding. It is estimated that 90% of adults worldwide have HSV-1 antibodies. Cutaneous HSV-1 infections are characterized by a sensation of tingling or numbness at the initial infection site followed by an eruption of vesicles and then painful ulcers with crusting. These symptoms can take ten days to several weeks to heal, leading to significant morbidity. Histologically, infections cause ballooning degeneration of keratinocytes and formation of multinucleated giant cells, ultimately resulting in a localized immune response. Commonly prescribed treatments against HSV-1 infections are nucleoside analogs, such as acyclovir (ACV). However, the emergence of ACV-resistant HSV (ACVR-HSV) clinical isolates has created an urgent need for the development of compounds to control symptoms of cutaneous infections. RLS-0071, also known as peptide inhibitor of complement C1 (PIC1), is a 15-amino-acid anti-inflammatory peptide that inhibits classical complement pathway activation and modulates neutrophil activation. It has been previously shown to aid in the healing of chronic diabetic wounds by inhibiting the excessive activation of complement component C1 and infiltration of leukocytes. Here, we report that treatment of cutaneous infections of HSV-1 and ACVR-HSV-1 in BALB/cJ mice with RLS-0071 significantly reduced the rate of mortality, decreased zosteriform spread, and enhanced the healing of the infection-associated lesions compared to control-treated animals. Therefore, RLS-0071 may work synergistically with other antiviral drugs to aid in wound healing of HSV-1 cutaneous infection and may potentially aid in rapid wound healing of other pathology not limited to HSV-1.
The Role of Capsid in HIV-1 Nuclear Entry
Authors: Guedán Anabel , Caroe Eve R. , Barr Genevieve C. R. , Bishop Kate N.
Published: July 2021

HIV-1 can infect non-dividing cells. The nuclear envelope therefore represents a barrier that HIV-1 must traverse in order to gain access to the host cell chromatin for integration. Hence, nuclear entry is a critical step in the early stages of HIV-1 replication. Following membrane fusion, the viral capsid (CA) lattice, which forms the outer face of the retroviral core, makes numerous interactions with cellular proteins that orchestrate the progress of HIV-1 through the replication cycle. The ability of CA to interact with nuclear pore proteins and other host factors around the nuclear pore determines whether nuclear entry occurs. Uncoating, the process by which the CA lattice opens and/or disassembles, is another critical step that must occur prior to integration. Both early and delayed uncoating have detrimental effects on viral infectivity. How uncoating relates to nuclear entry is currently hotly debated. Recent technological advances have led to intense discussions about the timing, location, and requirements for uncoating and have prompted the field to consider alternative uncoating scenarios that presently focus on uncoating at the nuclear pore and within the nuclear compartment. This review describes recent advances in the study of HIV-1 nuclear entry, outlines the interactions of the retroviral CA protein, and discusses the challenges of investigating HIV-1 uncoating.
Virucidal Efficacy of Blue LED and Far-UVC Light Disinfection against Feline Infectious Peritonitis Virus as a Model for SARS-CoV-2
Authors: Gardner Amanda , Ghosh Sayani , Dunowska Magdalena , Brightwell Gale
Published: July 2021

Transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occurs through respiratory droplets passed directly from person to person or indirectly through fomites, such as common use surfaces or objects. The aim of this study was to determine the virucidal efficacy of blue LED (405 nm) and far-UVC (222 nm) light in comparison to standard UVC (254 nm) irradiation for the inactivation of feline infectious peritonitis virus (FIPV) on different matrices as a model for SARS-CoV-2. Wet or dried FIPV on stainless steel, plastic, or paper discs, in the presence or absence of artificial saliva, were exposed to various wavelengths of light for different time periods (1–90 min). Dual activity of blue LED and far-UVC lights were virucidal for most wet and dried FIPV within 4 to 16 min on all matrices. Individual action of blue LED and far-UVC lights were virucidal for wet FIPV but required longer irradiation times (8–90 min) to reach a 4-log reduction. In comparison, LED (265 nm) and germicidal UVC (254 nm) were virucidal on almost all matrices for both wet and dried FIPV within 1 min exposure. UVC was more effective for the disinfection of surfaces as compared to blue LED and far-UVC individually or together. However, dual action of blue LED and far-UVC was virucidal. This combination of lights could be used as a safer alternative to traditional UVC.
Severe COVID-19 by SARS-CoV-2 Lineage B.1.1.7 in Vaccinated Solid-Organ Transplant Recipients: New Preventive Strategies Needed to Protect Immunocompromised Patients
Authors: Loconsole Daniela , Stea Emma Diletta , Sallustio Anna , Fontò Giulia , Pronzo Virginia , Simone Simona , Centrone Francesca , Accogli Marisa , Gesualdo Loreto , Chironna Maria
Published: July 2021

Background: Solid-organ transplant (SOT) recipients are at a high risk of severe COVID-19, and are priority for vaccination. Here, we describe three cases of severe COVID-19 caused by SARS-CoV-2 B.1.1.7 lineage in vaccinated SOT recipients. Methods: Three SOT patients were hospitalized in the Policlinico Hospital of Bari (southern Italy) and underwent nasopharyngeal swabs for molecular detection of SARS-CoV-2 genes and spike protein mutations by real-time PCR. One sample was subjected to whole-genome sequencing. Results: One patient was a heart transplant recipient and two were kidney transplant recipients. All were hospitalized with severe COVID-19 between March and May 2021. Two patients were fully vaccinated and one had received only one dose of the BNT162b2 mRNA vaccine. All the patients showed a high viral load at diagnosis, and molecular typing revealed the presence of B.1.1.7 lineage SARS-CoV-2. In all three cases, prolonged viral shedding was reported. Conclusions: The three cases pose concern about the role of the B.1.1.7 lineage in severe COVID-19 and about the efficacy of COVID-19 vaccination in immunocompromised patients. Protecting immunocompromised patients from COVID-19 is a challenge. SOT recipients show a suboptimal response to standard vaccination, and thus, an additive booster or a combined vaccination strategy with mRNA, protein/subunit, and vector-based vaccines may be necessary. This population should continue to practice strict COVID-19 precautions post-vaccination, until new strategies for protection are available.
Regional Delivery of Anti-PD-1 Agent for Colorectal Liver Metastases Improves Therapeutic Index and Anti-Tumor Activity
Authors: Chai Louis F. , Hardaway John C. , Heatherton Kara R. , O’Connell Kyle P. , Lopes Mikayla C. , Rabinowitz Benjamin A. , Ghosh Chandra C. , Guha Prajna , Jaroch David , Cox Bryan F. , Katz Steven C.
Published: July 2021

Metastatic liver tumors have presented challenges with the use of checkpoint inhibitors (CPIs), with only limited success. We hypothesize that regional delivery (RD) of CPIs can improve activity in the liver and minimize systemic exposure, thereby reducing immune-related adverse events (irAE). Using a murine model of colorectal cancer liver metastases (LM), we confirmed high levels of PD-L1 expression on the tumor cells and liver myeloid-derived suppressor cells (L-MDSC). In vivo, we detected improved LM response at 3 mg/kg on PTD7 via portal vein (PV) regional delivery as compared to 3 mg/kg via tail vein (TV) systemic delivery (p = 0.04). The minimal effective dose at PTD7 was 5 mg/kg (p = 0.01) via TV and 0.3 mg/kg (p = 0.02) via PV. We detected 6.7-fold lower circulating CPI antibody levels in the serum using the 0.3 mg/kg PV treatment compared to the 5 mg/kg TV cohort (p < 0.001) without increased liver toxicity. Additionally, 3 mg/kg PV treatment resulted in increased tumor cell apoptotic signaling compared to 5 mg/kg TV (p < 0.05). Therefore, RD of an anti-PD-1 CPI therapy for CRCLM may improve the therapeutic index by reducing the total dose required and limiting the systemic exposure. These advantages could expand CPI indications for liver tumors.
HPV Vaccination in Women Treated for Cervical Intraepithelial Neoplasia: A Budget Impact Analysis
Authors: Basile Michele , Calabrò Giovanna Elisa , Ghelardi Alessandro , Ricciardi Roberto , De Vincenzo Rosa , Cicchetti Americo
Published: July 2021

Human Papillomavirus (HPV) is the most common sexually transmitted infection. Its progression is related to the development of malignant lesions, particularly cervical intraepithelial neoplasias (CINs). CINs correlate with a higher risk of premature births, and their excisional and ablative treatment further increases this risk in pregnant women. These complications are also correlated with higher healthcare costs for their management. In Italy, more than 26,000 new cases of CINs are estimated to occur yearly and their economic burden is significant. Therefore, the management of these conditions is a public health priority. Since HPV vaccination is associated with a reduced risk of relapse in women surgically treated for HPV-related injuries, we estimated the economic impact of extending HPV vaccination to this target population. This strategy would result in a significant reduction in the general costs of managing these women, resulting in an overall saving for the Italian Health Service of €155,596.38 in 5 years. This lower cost is due not only to the reduced incidence of CINs following vaccination, but also to the lower occurrence of preterm births. Extending HPV vaccination to this target population as part of a care path to be offered to women treated for HPV injuries is therefore desirable.
Examining the Applicability of Wavelet Packet Decomposition on Different Forecasting Models in Annual Rainfall Prediction
Authors: Wang Hua , Wang Wenchuan , Du Yujin , Xu Dongmei
Published: July 2021

Accurate precipitation prediction can help plan for different water resources management demands and provide an extension of lead-time for the tactical and strategic planning of courses of action. This paper examines the applicability of several forecasting models based on wavelet packet decomposition (WPD) in annual rainfall forecasting, and a novel hybrid precipitation prediction framework (WPD-ELM) is proposed coupling extreme learning machine (ELM) and WPD. The works of this paper can be described as follows: (a) WPD is used to decompose the original precipitation data into several sub-layers; (b) ELM model, autoregressive integrated moving average model (ARIMA), and back-propagation neural network (BPNN) are employed to realize the forecasting computation for the decomposed series; (c) the results are integrated to attain the final prediction. Four evaluation indexes (RMSE, MAE, R, and NSEC) are adopted to assess the performance of the models. The results indicate that the WPD-ELM model outperforms other models used in this paper and WPD can significantly enhance the performance of forecasting models. In conclusion, WPD-ELM can be a promising alternative for annual precipitation forecasting and WPD is an effective data pre-processing technique in producing convincing forecasting models.
Advances in Catchment Science through Integrated Hydrological Modelling and Monitoring
Authors: Bertoldi Giacomo , Camporese Matteo , Sulis Mauro
Published: July 2021

Environmental research is rapidly evolving toward an integration of different disciplines, and this is also reflected in hydrology and the hydrological modelling community [...]
Spatial and Temporal Vertical Distribution of Chlorophyll in Relation to Submarine Wastewater Effluent Discharges
Authors: Kvesić Marija , Vojković Marin , Kekez Toni , Maravić Ana , Andričević Roko
Published: July 2021

The vertical distribution of chlorophyll in coastal waters is influenced by a combination of the hydrodynamic environment and different biotic and abiotic processes. The spatial and temporal occurrences of chlorophyll profiles provide a good representation of the changes in the marine environment. The majority of studies in the Adriatic Sea have so far been conducted in areas unaffected by anthropogenic pressure. Our study site is located near two marine outfalls, which are part of the public sewage system. This study aims to characterize the chlorophyll vertical distribution and describe its variability based on the stratification conditions and the presence of a wastewater effluent plume. Based on these conditions, we identified three characteristic scenarios/types of chlorophyll profiles. The first one occurs when the vertical mixing of the water column creates the upwelling of chlorophyll and nutrients to the upper part of the water column. The second and third scenarios occur during stratified conditions and differ by the extent of the effluent plume intrusion. Using modern fluorescence techniques, we identified and described three different vertical chlorophyll profiles, characterizing them according to their physical and biological parameters and processes. For cases with a visible effluent intrusion, we confirmed the importance of the pycnocline formation in keeping the effluent below and maintaining the higher water quality status at the top of the water column.
Color models used for the visual interpretation of satellite data
Authors: Jelev Georgi
Published: July 2021

This study presents the possibilities for using different colour models for visual interpretation of satellite imagery. Using the RGB model to visualise different spectral bands as a false colour composite image make it possible for different types of objects and features on the Earth surface to be highlighted and easily discerned based on their specific colour. Examples are shown based on satellite imagery from several free sources, e.g. the USGS’s Earth Explorer, the ESA’s Copernicus Open Access Hub, etc.
Option of training for sustainable development and environment througt examples of problem – situation methods
Authors: Gyulemetova Mariya
Published: July 2021

In a rapidly changing social and natural environment, higher education is called upon to play a very complex and multi-faceted role in the process of sustainable development.The purpose of the article is to share a training option for sustainable development and the environment through examples of problem – situation methods.
Lessons Learned from the Development of the North Carolina Extension Master Food Volunteer Program
Authors: Bloom Dara , Yao Julia , Edwards Harriett
Published: July 2021

This article describes the curriculum and program development process that was used to create the North Carolina Extension Master Food Volunteer program. We used a rigorous program development process, including conducting a needs assessment, piloting and evaluating the program, incorporating revisions based on feedback, and receiving external reviews that were incorporated into the final product. We provide lessons learned and best practices for others to follow. These include the importance of piloting the program, involving agents and key partners throughout the entire process, and providing flexibility and adaptability in program delivery.
4-H Youth Development Programming in Indigenous Communities: A Critical Review of Cooperative Extension Literature
Authors: Farella Joshua , Hauser Mike , Parrott Amy , Moore Joshua , Penrod Meghan , Elliott-Engel Jeremy
Published: July 2021

A literature review was conducted using the key words relating to Native American Youth and 4-H to assess the current state of 4-H youth programming serving First Nation/ Indigenous populations to inform future Extension initiatives. A systematic and qualitative review determined what level of focus the conducted programming efforts placed on broadly accepted elements of cultural identity as noted in the Peoplehood Model. A very small number of articles (N=13) were found pertaining to 4-H and Indigenous Communities. Fewer demonstrated emphasis on the peoplehood elements of language, place, traditional ceremony or calendars, and history. This work investigates a continuing inequity in 4-H PYD–both in service and reporting–and suggests some next steps for creating a more inclusive 4-H program for Native American/First Nation/Indigenous youth.
Evaluation of the Thermal properties of Epoxy-Agro waste (Egg shell and Palm kernel shell) Nanoparticle coating for Mild Steel
Authors: OİSAKEDE Maureen
Published: July 2021

Epoxy has been widely used as a coating material to protect the steel reinforcement in concrete structures, because of its outstanding processability, excellent chemical resistance, good electrical insulating properties, and strong adhesion/affinity. The major disadvantage raised from exothermic curing reaction of highly crosslinked epoxy matrix is brittleness and microcracks that change the epoxy coating performances. The barrier performance of epoxy coatings can be enhanced by the incorporation of inorganic filler particles at nanometer scale which can be dispersed within the epoxy resin matrix to form an epoxy nanocomposite. The parametric addition of eggshell ash nanoparticles (ESAnp) and palm kernel shell ash nanoparticle (PKSAnp) in epoxy for the coating of mild steel was studied. Thermal decomposition was observed in terms of global mass loss by using a TGA Q50 thermogravimetric analyzer. Improvement of 78.05% and 82.56% thermal properties were obtained for the epoxy-4wt%ESAnp and epoxy-5wt%PKSAnp at 1000°C. This work showed that epoxy-4wt%ESAnp and epoxy-5wt%PKSAnp have best properties for thermal applications.
Görüntüdeki Farklı Nesneyi Renk ve Şekil Özelliklerini Kullanarak Tespit Etme
Authors: ALTAY AÇAR Şafak
Published: July 2021

Bu çalışmada bir görüntü üzerindeki nesnelerden farklı olanı tespit eden iki farklı yöntem sunulmaktadır. İlk yöntemde görüntüdeki nesnelerin renk özellikleri kullanılmaktadır. İkinci yöntemde ise şekil özellikleri kullanılmaktadır. Öncelikle görüntü üzerindeki nesneler 2 girişli ve 6 çıkışlı bir yarışmacı öğrenme ağı ile kümelendirilerek belirlenmektedir. Sonra da sunulan yöntemlerden biri kullanılarak nesnelerden farklı olan tespit edilmektedir. Deneysel çalışmalarda 80 farklı nesne ve 160 farklı görüntü kullanılmıştır. Renk özelliklerini kullanan yöntem %90 başarı elde etmiştir. Şekil özelliklerini kullanan yöntem %73.75 başarı elde etmiştir. Elde edilen sonuçlar birbirleriyle karşılaştırılarak değerlendirilmiştir. Ayrıca yarışmacı öğrenme ağının kümelendirme performansı da ayrıyeten incelenmiştir. Gelecek çalışmalar hakkında öneriler sunulmuştur.
Freudiana: az örökség tovább él
Authors: Simó Ferenc Zoltán
Published: July 2021

Ezen tanulmány egy trilógia második részének tekinthető, amely előkészít (terveink szerint) egy következő publikációt (angol nyelven), amelyben a „Freudiana” jelenlegi megítélését/tovább élését vizsgáljuk főként a 21. században, különös tekintettel a pszichológiai, nevelési és kulturális nézőpontokra. A „Freudiana” kifejezés Todd Dufresne-től (2003) származik, amelyet a szerző a freudi életmű egészére használ a Killing Freud című művében. A Freud által képviselt látásmód és azzal együtt felbukkanó diszkurzus már a legelső pillanatoktól fogva megtalálta kővetőit és szélsőséges módon lojális híveit, de nyilvánvalóan nem maradt el az elméleteit ellenzők megjelenése sem. A vizsgálatunk tárgya a freudi örökség továbbélése különböző diskurzusokban.
Stomatitis sebagai Manifestasi Oral dari Anemia Defisiensi Zat Besi disertai Trombositosis
Authors: Mersil Sarah
Published: July 2021

Abstract: Studies in Indonesia stated that the main cause of nutritional anemia in adolescents is due to lack of iron intake, which is called iron deficiency anemia. One of its oral manifestations is stomatitis. Thrombocytosis is also found in iron deficiency anemia. We reported a case of a 22-year-old female patient with complaints of stomatitis and further examination showed the occurrence of iron deficiency anemia and thrombocytosis. The patient was instructed to maintain good diet containing meat, vitamin C-rich vegetables and fruits, have good sleep pattern, take care of her oral health, and not to force herself to overwork. Triamcinolone acetonide in ora base 0.1% was applied on the lesion by using cotton bud after meal and before bedtime until the lesion disappeared or became painless. The patient was referred to an internist for further examination. After two weeks, the lesion had disappeared, and there was no new lesion. However, the patient had not checked to the internist, therefore, ferrous gluconate 250 mg twice daily was given to her for 30 days. In conclusion, the patient was diagnosed as stomatitis aphthosa as an oral manifestation of iron deficiency anemia associated with secondary thrombocytosis.Keywords: stomatitis, iron deficiency anemia, thrombocytosis Abstrak: Penelitian di Indonesia menyatakan bahwa penyebab utama terjadinya anemia gizi pada remaja ialah kurangnya asupan zat besi, yang disebut anemia defisiensi zat besi. Salah satu manifestasi oralnya ialah stomatitis. Kondisi trombositosis juga ditemukan pada anemia defisiensi zat besi. Kami melaporkan kasus seorang perempuan berusia 22 tahun dengan keluhan stomatitis dan hasil pemeriksaan penunjang menunjukkan anemia defisiensi zat besi dan trombositosis. Pasien diinstruksikan untuk menjaga pola makan yang baik dengan mengonsumsi daging serta buah dan sayuran mengandung vitamin C, tidur serta istirahat yang cukup, tidak memaksakan diri secara berlebihan, serta menjaga kebersihan mulut. Diberikan obat oles yaitu triamcinolone acetonide in orabase 0,1% untuk dioles pada lesi menggunakan cotton bud sehabis makan dan sebelum tidur sampai lesi sembuh atau tidak sakit lagi. Pasien dirujuk ke spesialis penyakit dalam untuk tindak lanjut dari kondisi sistemiknya. Kontrol setelah dua minggu sariawan sudah hilang, tidak muncul sariawan baru. Pasien belum ke dokter spesialis penyakit dalam untuk memeriksa kondisi anemia yang dideritanya. Oleh karena itu diberikan ferrous gluconate 250 mg dua kali sehari selama 30 hari. Simpulan kasus ini ialah suatu stomatitis sebagai salah satu manifestasi oral pada anemia defisiensi besi yang disertai trombositosis sekunder.Kata kunci: stomatitis, anemia defisiensi zat besi, trombositosis
ON THE REFLECTION OF CORONOMICS IN ECONOMIC SCIENCE AND ECONOMIC POLICY
Authors: PAPAVA VLADIMER
Published: July 2021

The paper discusses the economic issues of the COVID-19 pandemic. The resulting coronomic crisis is not a typical economic crisis since the coronomic crisis was not formed in the economy itself but is the result of the inability of medicine to solve the pandemic problem. The coronomic crisis is, by its very nature, an atypical economic crisis and is fundamentally different from other atypical economic crises that took place in the XX century. The coronomic crisis put the issue of the “crisis of globalization” on the agenda. The coronomic crisis exposed the weaknesses of globalization. Overcoming
the COVID-19 pandemic is possible exclusively at the global level. The paper shows that the current process of de-globalization is “forced” by its nature and it will definitely be replaced by a qualitatively renewed process of globalization. Economic
recovery from the corona crisis will be most successful only on the basis of the adherence to a free trade regime. In economic science, the problem of government intervention in the economy, especially during the pandemic and the post-pandemic
period, is still relevant. The corona crisis has clearly confirmed the inability of inflation targeting to achieve macroeconomic stability. The coronomic crisis requires two approaches to economic policy. In particular, we mean an anti-crisis economic
policy and a post-crisis economic policy. Economic incentives provided by the government to businesses contribute to the zombieing of the economy which will be one of the most difficult problems of the post-crisis period. The coronomic crisis
made the issue of the economic security of each individual country even more urgent. The problem of ensuring food security is equally important. The economic policy of the post-crisis period must necessarily include measures to ensure a country’s
food security. Since the possibility of a repetition of a pandemic in the future is similar to the current one, the problems of coronomics should remain in the field of study of economists for many years.
Analisis Penurunan Tanah dengan Plaxis 2D dan 3D Pada Proyek Reklamasi Belawan
Authors: Surbakti Rudianto
Published: July 2021

Penurunan tanah adalah masalah yang sering ditemukan pada konstruksi diatas tanah lunak selain pergerakan tanah dan pergeseran tanah. Tanah dengan konsistensi lunak dan memiliki permeabilitas rendah akan lambat mengalirkan air pori dalam tanah sehingga diperlukan penanganan khusus untuk mempercepat prosesnya. Salah satu metode untuk mempercepat proses pengaliran air pori pada tanah dasar yaitu dengan memberikan beban Preloading dan pemancang PVD (Pre-fabricated Vertical Drain). PVD mampu mempercepat keluarnya air pori tanah sehingga proses konsolidasi bisa berlangsung lebih cepat. Data harian penurunan tanah yang terjadi di lapangan dicatat dari settlement plate yang dipasang di lapangan. Analisis ini bertujuan untuk mengetahui perbandingan antara penurunan tanah yang dihitung menggunakan program Plaxis 2D dan 3D dibandingkan dengan penurunan yang tercatat pada settlement plate. Analisis menunjukkan bahwa besar penurunan yang terjadi pada Plaxis 2D adalah 6,47 meter dan dari analisis Plaxis 3D adalah 6,356 meter. Penurunan yang terjadi menurut pengamatan settlement plate di lapangan adalah 6,32 meter. Dapat disimpulkan bahwa analisis dengan menggunakan Plaxis 3D lebih mendekati penurunan hasil observasi dibandingkan dengan menggunakan Plaxis 2D.
Analisis Kondisi Kerusakan Jaringan Irigasi Setupatok Kabupaten Cirebon
Authors: Apriyanto Sonie
Published: July 2021

Penelitian ini bertujuan untuk menganalisis kondisi kerusakan bangunan dan saluran induk serta kebocoran yang terjadi di sepanjang saluran induk Daerah Irigasi Setupatok, pada penelitian ini dilaksanakan dengan cara penelusuran saluran induk argasunya dan saluran induk Luwung di dasarkan pada Peraturan Menteri Pekerjaan Umum dan Perumahan Rakyat Nomer 12/PRT/M/2015 Tentang eksploitasi dan pemeliharaan jaringan irigasi pada bab 11.2.9 yang menjelaskan tentang Kondisi Kerusakan Jaringan Irigasi, sedangkan untuk kebocoran air pada saluran Induk Daerah Irigasi Setupatok menggunakan perhitungan fluida dinamis. Hasil analisis menunjukan bahwa Kondisi Kerusakan Bangunan dan Saluran Induk Argasunya kondisi baik 71,19 %, kondisi rusak ringan 1,01 %, kondisi rusak sedang 22.44 % , kondisi rusak berat 5.31 %. dan Saluran Induk Luwung kondisi baik 56,19 %, kondisi rusak sedang 6.80 % , kondisi rusak berat 37,02 %. untuk kondisi kebocoran air pada saluran induk Argasunya dan induk Luwung sebesar 330 liter / detik.
Perancangan Sistem Informasi Inventory dan Penjualan Menggunakan Visual Studio
Authors: Ramdhany Asep , Irawan Dena
Published: July 2021

Sistem penjualan Handphone yang disediakan oleh Anis Cell yang sedang berjalan sekarang adalah masih secara manual didalam beberapa kegiatan-kegiatan atau proses-prosesnya yang antara lain adalah proses pengolahan data pelanggan, proses pengolahan data Handphone, proses pengolahan data transaksi, proses pengolahan data laporan. Tujuan dari penelitian ini adalah untuk mengetahui suatu proses yang ada dalam sistem dan siapa saja pelaku-pelaku yang terkait, serta untuk mengetahui apakah yang dihasilkan oleh suatu pihak sudah sesuai kebutuhan. Metode pengumpulan data yang dibuat dengan cara observasi, wawancara, dan studi literatur atau kajian pustaka yang memiliki relevansi erat dengan pokok permasalahan yaitu sistem yang dibuat bernama sistem informasi penjualan Handphone. Hasil penelitian ini menunjukkan bahwa sistem yang dibuat untuk lebih mengoptomatiskan sistem penjualan Handphone yang lama, menyimpan data dalam suatu basis data dan memberikan informasi penjualan dengan cepat dan tepat. Sistem Informasi Penjualan Handphone ini dibuat dengan Visual Studio 2008 dan SQL Server sebagai database. Perbaikan sistem informasi yang ada dengan menggunakan sistem informasi penjualan Handphone yang telah terkomputerisasi dan mengganti sistem yang sedang berjalan sekarang dengan sistem baru yang lebih cepat, efektif, dan efisien.
Perbedaan Pemberian Asi Ekslusif dengan yang Tidak Ekslusif Terhadap Pertumbuhan pada Balita Di UPTD Puskesmas Krangkeng Kabupaten Indramayu
Authors: Iis Iis , Rohaeni Ela
Published: July 2021

Air Susu Ibu (ASI) Ekslusif yang diberikan kepada bayi semenjak dilahirkan sampai dengan usia 6 (enam) bulan adalah asupan makanan yang paling baik karena dalam ASI mengandung kolostrum yang kaya akan antibodi. Antibodi mengandung banyak protein untuk daya tahan tubuh dan bermanfaat untuk mematikan kuman dalam jumlah tinggi, sehingga pemberian ASI eksklusif dapat mengurangi risiko kematian pada bayi. Tujuan penelitian untuk mengetahui perbedaan pemberian ASI Eksklusif dengan yang tidak Eksklusif terhadap pertumbuhan pada balita di UPTD Puskesmas Krangkeng Kabupaten Indramayu. Penelitian ini menggunakan penelitian kuantitatif dengan pendekatan komparatif korelasional. Pengumpulan data dilakukan dengan menggunakan kuesioner. Populasi dalam penelitian ini adalah Seluruh balita di UPTD Puskesmas Krangkeng Kabupaten Indramayu sebanyak 4.029 balita. Sampel yang diambil berjumlah 38 orang dengan menggunakan teknik purposive sampling. Berdasarkan hasil penelitian didapatkan hasil sebagai berikut: 1) Rata-rata pertumbuhan pada balita yang tidak diberi ASI eksklusif adalah 8,96 dan mediannya 8,75 dengan standar deviasinya 1,447. Pertumbuhan paling rendah 7,0 dan paling tinggi 13,0. Berdasarkan nilai 95% CI, diketahui bahwa pertumbuhan balita pada kelompok yang tidak diberi ASI eksklusif berkisar antara 8,14-9,80. Sedangkan rata-rata pertumbuhan pada balita yang diberi ASI eksklusif adalah 11,7 dan mediannya 10,5 dengan standar deviasinya 8,042. Pertumbuhan paling rendah 10,51 dan paling tinggi 12,91. Berdasarkan nilai 95% CI, diketahui bahwa pertumbuhan balita pada kelompok yang diberi ASI eksklusif berkisar antara 10,51-12,91. 2) Rata-rata pertumbuhan pada balita yang tidak diberi ASI eksklusif adalah 8,96, sedangkan rata-rata pertumbuhan pada balita yang diberi ASI eksklusif adalah 11,7, hal ini berarti ada perbedaan sebesar 2,74.
Analisis Perbandingan Persepsi Pelanggan Terhadap Bauran Pemasaran Kopi Janji Jiwa Dan Kopi Kenangan
Authors: Christian Ivan , Kartawidjaja Jesslyn
Published: July 2021

Banyaknya kedai kopi di Kota Bandung membuat persaingan antar Kedai Kopi semakin ketat. Karena itu, penerapan bauran pemasaran yang tepat akan sangat berpengaruh terhadap minat pelanggan dalam memilih Kedai Kopi. Kopi Janji Jiwa Braga merupakan salah satu kedai kopi terlaris di Kota Bandung. Namun seiring didirikannya Kopi kenangan Braga, Kopi Janji Jiwa Braga memiliki pesaing langsung. Penelitian ini bertujuan untuk mengetahui perbandingan persepsi pelanggan terhadap bauran pemasaran di Kopi Janji Jiwa Braga dan Kopi Kenangan Braga. Bauran pemasaran yang diteliti meliputi 7 elemen dan 29 indikator bauran pemasaran. Metode yang digunakan dalam penelitian ini adalah metode deskriptif. Populasi dari penelitian ini adalah pelanggan yang pernah mengunjungi Kopi Janji Jiwa Braga dan Kopi Kenangan Braga. Sampel yang digunakan sebanyak 122 orang. Teknik pengumpulan data yang dipakai adalah observasi, wawancara, dan kuesioner. Teknik analisis data yang digunakan yaitu deskriptif dan uji beda Mann Whitney. Hasil penelitian menunjukkan bahwa persepsi pelanggan terhadap bauran pemasaran Kopi Janji Jiwa Braga dan Kopi Kenangan Braga adalah positif. Persepsi pelanggan terhadap 7 elemen bauran pemasaran Kopi janji Jiwa Braga dan Kopi Kenangan Braga adalah positif. Persepsi pelanggan terhadap 29 indikator bauran pemasaran Kopi Janji Jiwa Braga dan Kopi Kenangan Braga adalah setuju kecuali indikator keunikan dan pencahayaan Kopi Kenangan Braga yang hasilnya cukup setuju. Dari 29 indikator persepsi pelanggan terhadap bauran pemasaran Kopi Janji Jiwa Braga dan Kopi Kenangan Braga, 12 indikator tidak berbeda sedangkan 17 indikator berbeda.
CARACTERIZAÇÃO FÍSICO-QUÍMICA DE VINHOS BRANCOS DE MESA ELABORADOS NO PLANALTO NORTE CATARINENSE
Authors: Wurz Douglas Andre , Jastrombek Jessiane Mary
Published: July 2021

Com o presente trabalhou objetivou-se realizar a caracterização físico-química dos vinhos brancos de mesa elaborados no Planalto Norte Catarinense, verificando se enquadram nos padrões físico-químicos exigidos pela legislação vigente e se apresentam características sensoriais qualitativas. O presente trabalho foi realizado no Instituto Federal de Santa Catarina – Câmpus Canoinhas, no ano de 2019. Os vinhos brancos de mesa foram coletados diretamente de cinco viticultores do Planalto Norte Catarinense, sendo as cinco amostras da safra 2019. As análises foram realizadas em triplicata, e as variáveis avaliadas foram: densidade relativa, acidez total titulável, sólidos solúveis, pH e coloração dos vinhos (Abs 420 nm). A vitivinicultura no Planalto Norte Catarinense apresenta potencial de se desenvolver, e os vinhos caracterizados através de análises físico-químicas indicam que os vinhos elaborados na região apresentam potencial qualitativo, contudo, é necessário aperfeiçoamento nos processos de elaboração para melhorar a qualidade final dos vinhos brancos de mesa. Predomina a elaboração de vinhos secos, na qual, em um total de cinco amostras, apenas uma apresentou características físico-química de um vinho suave.
ELABORAÇÃO DE ROTEIROS EXPERIMENTAIS PARA PROCESSOS DE SEPARAÇÃO DE MISTURAS
Authors: Goldner Moreira Silvana , Fabris Hellen , Rechel Radinz Isabel Helena , Jacobsen Ramos João Vitor
Published: July 2021

O conteúdo de processos de separação de misturas contém uma grande variedade de técnicas, que são utilizadas na purificação da água, na indústria química e em nossas casas. Para melhorar o processo de ensino e aprendizagem deste assunto é preciso associar aulas teóricas e práticas. Porém, muitas vezes a realização de experimentos é impossibilitada pela falta de recursos. Assim, neste trabalho, foram pesquisadas e testadas práticas sobre os processos de separação de misturas com reagentes e materiais de baixo custo. Os experimentos envolvendo os processos de filtração, decantação, floculação, destilação, cristalização, sublimação, separação magnética, extração e cromatografia foram pesquisados em revistas on-line, livros, apostilas, sites e vídeos do YouTube da área de ensino de Ciências e, depois, testados e ajustados. Experimentos envolvendo os seguintes temas foram selecionados: filtração simples, filtração a vácuo, adsorção usando carvão ativado, decantação líquido-líquido, construção de uma centrífuga, simulação da floculação e da filtração das estações de tratamento de água, destilação usando lâmpada incandescente, crescimento de cristais com o uso de vinagre e de sulfato de cobre II penta-hidratado, sublimação da naftalina e do iodo, separação do fubá e limalha de ferro, extração de óleo da casca de laranja e de DNA da cebola, cromatografia em papel com canetas esferográficas e hidrográficas, e cromatografia em giz com canetas hidrográficas. Então, foi elaborada uma apostila contendo os roteiros de cada um desses experimentos para ficar à disposição dos professores de química do Ifes campus Colatina para uso com as turmas dos cursos técnicos integrados ao ensino médio.
Design an Adaptive Hybrid Approach for Genetic Algorithm to Detect Effective Malware Detection in Android Division
Authors: Vivekanandam B
Published: July 2021

Data pre-processing is critical for handling classification issues in the field of machine learning and model identification. The processing of big data sets increases the computer processing time and space complexity while decreasing classification model precision. As a result, it is necessary to develop an appropriate method for selecting attributes. This article describes a machine learning technique to solve functional selection by safeguarding the selection and mutation operators of genetic algorithms. During population calculations in the training set, the proposed method is adaptable. Furthermore, for various population sizes, the proposed method gives the best possible probability of resolving function selection difficulties during training process. Furthermore, the proposed work is combined with a better classifier in order to detect the different malware categories. The proposed approach is compared and validated with current techniques by using different datasets. In addition to the test results, this research work utilizes the algorithm for solving a real challenge in Android categorization, and the results show that, the proposed approach is superior. Besides, the proposed algorithm provides a better mean and standard deviation value in the optimization process for leveraging model effectiveness at different datasets.
Challenges and Opportunities of E-Procurement in the Construction Industry
Authors:   Department of Civil Engineering, Kaduna Polytechnic, PMB 2021 Kaduna, Nigeria, Hamma-adama Mansur , Ahmad Abdul-Basit Sa’eed ,   Department of Civil Engineering, Kaduna Polytechnic, PMB 2021 Kaduna, Nigeria
Published: July 2021

Construction Industry is evolving amid the fourth industrial revolution. Transportation, commerce, manufacturing and many other industries ripened the current technological advancement and are striving to utilise every development in the IT sector. The procurement of construction works is known to be very conventional and backward in the adoption of digitalisation. The construction industry's procurement and supply chain are blamed for the most inflated cost of construction projects, mainly attributed to a lack of transparency and trust between the industry stakeholders. This research explores the challenges of E-procurement adoption in the industry and identifies the potential opportunities for its usage. This investigation's data are acquired through interviews, and the data are analysed using qualitative content analysis. This study reveals compounding challenges (i.e., corruption and lack of commitment) that lead to the failure of such efforts in Nigeria and the potential prospects (i.e., transparency and efficiency). This study is essential in developing a more effective and transparent process of procurement so that the Nigerian construction industry is not be left behind in the fast-digitalising markets.
CONCEPTUAL PRINCIPLES OF BIOECONOMY AND ITS RELATIONS WITH RATIONAL NATURAL RESOURCES USE IN UKRAINE
Authors: Ilina Mariia , Shpylova Yuliia
Published: July 2021

Scarcity of the natural resources, exciting global environmental problems, climate change, soil and ecosystem degradation accompanying with the population growth force to searching new consumption and production patterns. Appropriate modernization of the industries would impact into strengthening of the country's position in the world economy and conserve the natural resources. Achievement of these goals is possible with bioeconomy, which accompanied by digital technologies becomes the mechanism promoting the sustainable development. Bioeconomy is the new approach ensuring the rational use of natural resources and their conservation due to more efficient use of biological raw materials.
Goal of the article is substantiation of conceptual principles of the development of bioeconomy on Ukraine and discovery of its relations with the rational natural resources use.
Main areas of bioeconomy’s impact to the environment, economy and social sphere include improvement of the land use, conservation of the biodiversity and ecosystems, protection of the environment, expansion of the biotechnology markets, and making human lives better. The mentioned outcomes of the bioeconomy show its role in the rational use of natural resources, further commercialization of biotechnology and the following effects in social and economic spheres.
Today, Ukraine's share in the biotechnology market is negligible, and segments of biodegradable materials, bioplastics, and biofuels are completely absent. Among the possible factors for the development of the bioeconomy are the significant potential for agricultural biomass formation and organic production. The legislation gaps and shortcomings, lack of the national strategy for the development of bioeconomy, low economic capacity, scarcity of scientific researches on biotechnologies, and depletion of the human capital are the obstacles in this regard for Ukraine. Development of the new directions of bioeconomy will contribute to comprehensive solution of the problem of irrational use of natural resources and poor life of people by stimulus for the development of biotechnologies, making the market of innovations, protecting the environment and preserving the biodiversity.