bluuebunny/crossref_metadata_2025 huggingface dataset:
Bacterial Lipopolysaccharide Induces PD-L1 Expression and an Invasive Phenotype of Oral Squamous Cell Carcinoma Cells
Authors: Omori Yuji , Noguchi Kazuma , Kitamura Mizuha , Makihara Yuna , Omae Takayuki , Hanawa Soutaro , Yoshikawa Kyohei , Takaoka Kazuki , Kishimoto Hiromitsu
Published: January 2024

Background: Expression of programmed death ligand-1 (PD-L1) is related to the prognosis of many solid malignancies, including oral squamous cell carcinoma (OSCC), but the mechanism of PD-L1 induction remains obscure. In this study, we examined the expression of PD-L1 and partial epithelial–mesenchymal transition (pEMT) induced by bacterial lipopolysaccharide (LPS) in OSCC. Methods: The expression of Toll-like receptor 4 (TLR4) recognizing LPS in OSCC cell lines was analyzed. Moreover, the induction of PD-L1 expression by Porphyromonas gingivalis (P.g) or Escherichia coli (E. coli) LPS and EMT was analyzed by western blotting and RT-PCR. Morphology, proliferation, migration, and invasion capacities were examined upon addition of LPS. PD-L1 within EXOs was examined. Results: PD-L1 expression and pEMT induced by LPS of P.g or E. coli in TLR4-expressing OSCC cell lines were observed. Addition of LPS did not change migration, proliferation, or cell morphology, but increased invasive ability. Moreover, higher expression of PD-L1 was observed in OSCC EXOs with LPS. Conclusion: Oral bacterial LPS is involved in enhanced invasive potential in OSCC cells, causing PD-L1 expression and induction of pEMT. The enhancement of PD-L1 expression after addition of LPS may be mediated by EXOs.
Influencing Factors on the Quality of Lymph Node Dissection for Stage IA Non-Small Cell Lung Cancer: A Retrospective Nationwide Cohort Study
Authors: Gabryel Piotr , Skrzypczak Piotr , Roszak Magdalena , Campisi Alessio , Zielińska Dominika , Bryl Maciej , Stencel Katarzyna , Piwkowski Cezary
Published: January 2024

Lymphadenectomy is an essential part of complete surgical operation for non-small cell lung cancer (NSCLC). This retrospective, multicenter cohort study aimed to identify factors that influence the lymphadenectomy quality. Data were obtained from the Polish Lung Cancer Study Group Database. The primary endpoint was lobe-specific mediastinal lymph node dissection (L-SMLND). The study included 4271 patients who underwent VATS lobectomy for stage IA NSCLC, operated between 2007 and 2022. L-SMLND was performed in 1190 patients (27.9%). The remaining 3081 patients (72.1%) did not meet the L-SMLND criteria. Multivariate logistic regression analysis showed that patients with PET-CT (OR 3.238, 95% CI: 2.315 to 4.529; p < 0.001), with larger tumors (pT1a vs. pT1b vs. pT1c) (OR 1.292; 95% CI: 1.009 to 1.653; p = 0.042), and those operated on by experienced surgeons (OR 1.959, 95% CI: 1.432 to 2.679; p < 0.001) had a higher probability of undergoing L-SMLND. The quality of lymphadenectomy decreased over time (OR 0.647, 95% CI: 0.474 to 0.884; p = 0.006). An analysis of propensity-matched groups showed that more extensive lymph node dissection was not related to in-hospital mortality, complication rates, and hospitalization duration. Actions are needed to improve the quality of lymphadenectomy for NSCLC.
The Cross-Scale Association between Pathomics and Radiomics Features in Immunotherapy-Treated NSCLC Patients: A Preliminary Study
Authors: Dia Abdou Khadir , Ebrahimpour Leyla , Yolchuyeva Sevinj , Tonneau Marion , Lamaze Fabien C. , Orain Michèle , Coulombe Francois , Malo Julie , Belkaid Wiam , Routy Bertrand , Joubert Philippe , Després Philippe , Manem Venkata S. K.
Published: January 2024

Background: Recent advances in cancer biomarker development have led to a surge of distinct data modalities, such as medical imaging and histopathology. To develop predictive immunotherapy biomarkers, these modalities are leveraged independently, despite their orthogonality. This study aims to explore the cross-scale association between radiological scans and digitalized pathology images for immunotherapy-treated non-small cell lung cancer (NSCLC) patients. Methods: This study involves 36 NSCLC patients who were treated with immunotherapy and for whom both radiology and pathology images were available. A total of 851 and 260 features were extracted from CT scans and cell density maps of histology images at different resolutions. We investigated the radiopathomics relationship and their association with clinical and biological endpoints. We used the Kolmogorov–Smirnov (KS) method to test the differences between the distributions of correlation coefficients with the two imaging modality features. Unsupervised clustering was done to identify which imaging modality captures poor and good survival patients. Results: Our results demonstrated a significant correlation between cell density pathomics and radiomics features. Furthermore, we also found a varying distribution of correlation values between imaging-derived features and clinical endpoints. The KS test revealed that the two imaging feature distributions were different for PFS and CD8 counts, while similar for OS. In addition, clustering analysis resulted in significant differences in the two clusters generated from the radiomics and pathomics features with respect to patient survival and CD8 counts. Conclusion: The results of this study suggest a cross-scale association between CT scans and pathology H&E slides among ICI-treated patients. These relationships can be further explored to develop multimodal immunotherapy biomarkers to advance personalized lung cancer care.
Mitochondria-Targeted Nitronyl Nitroxide Radical Nanoparticles for Protection against Radiation-Induced Damage with Antioxidant Effects
Authors: Huang Shigao , Xu Min , Da Qingyue , Jing Linlin , Wang Haibo
Published: January 2024

Radiotherapy is a non-invasive method that is widely applied to treat and alleviate cancers. However, radiation-induced effects in the immune system are associated with several side effects via an increase in oxidative stress and the inflammatory response. Therefore, it is imperative to develop effective clinical radiological protection strategies for the radiological protection of the normal organs and immune system in these patients. To explore more effective radioprotective agents with minimal toxicity, a mitochondria-targeted nitronyl nitroxide radical with a triphenylphosphine ion (TPP-NIT) was synthesized and its nanoparticles (NPs-TPP-NIT) were prepared and characterized. The TPP-NIT nanoparticles (NPs-TPP-NIT) were narrow in their size distribution and uniformly distributed; they showed good drug encapsulation efficiency and a low hemolysis rate (<3%). The protective effect of NPs-TPP-NIT against X-ray irradiation-induced oxidative damage was measured in vitro and in vivo. The results show that NPs-TPP-NIT were associated with no obvious cytotoxicity to L-02 cells when the concentration was below 1.5 × 10−2 mmol. NPs-TPP-NIT enhanced the survival rate of L-02 cells significantly under 2, 4, 6, and 8 Gy X-ray radiation exposure; the survival rate of mice was highest after 6 Gy X-ray irradiation. The results also show that NPs-TPP-NIT could increase superoxide dismutase (SOD) activity and decrease malondialdehyde (MDA) levels after the L-02 cells were exposed to 6.0 Gy of X-ray radiation. Moreover, NPs-TPP-NIT could significantly inhibit cell apoptosis. NPs-TPP-NIT significantly increased the mouse survival rate after irradiation. NPs-TPP-NIT displayed a marked ability to reduce the irradiation-induced depletion of red blood cells (RBCs), white blood cells (WBCs), and platelets (PLTs). These results demonstrate the feasibility of using NPs-TPP-NIT to provide protection from radiation-induced damage. In conclusion, this study revealed that NPs-TPP-NIT may be promising radioprotectors and could therefore be applied to protect healthy tissues and organs from radiation during the treatment of cancer with radiotherapy.
Endoscopic Management of Gastro-Entero-Pancreatic Neuroendocrine Tumours: An Overview of Proposed Resection and Ablation Techniques
Authors: Chacchi-Cahuin Rocio , Despott Edward J. , Lazaridis Nikolaos , Rimondi Alessandro , Fusai Giuseppe Kito , Mandair Dalvinder , Anderloni Andrea , Sciola Valentina , Caplin Martyn , Toumpanakis Christos , Murino Alberto
Published: January 2024

A literature search of MEDLINE/PUBMED was conducted with the aim to highlight current endoscopic management of localised gastro-entero-pancreatic NETs. Relevant articles were identified through a manual search, and reference lists were reviewed for additional articles. The results of the research have been displayed in a narrative fashion to illustrate the actual state-of-the-art of endoscopic techniques in the treatment of NETs. Localised NETs of the stomach, duodenum and rectum can benefit from advanced endoscopic resection techniques (e.g., modified endoscopic mucosal resection, endoscopic full thickness resection, endoscopic submucosal dissection) according to centre expertise. Radiofrequency thermal ablation can be proposed as an alternative to surgery in selected patients with localised pancreatic NETs.
DNA Sequencing of CD138 Cell Population Reveals TP53 and RAS-MAPK Mutations in Multiple Myeloma at Diagnosis
Authors: Dragomir Mihaela , Călugăru Onda-Tabita , Popescu Bogdan , Jardan Cerasela , Jardan Dumitru , Popescu Monica , Aposteanu Silvia , Bădeliță Sorina , Nedelcu Gabriela , Șerban Cătălin , Popa Codruța , Vassu-Dimov Tatiana , Coriu Daniel
Published: January 2024

Multiple myeloma is a hematologic neoplasm caused by abnormal proliferation of plasma cells. Sequencing studies suggest that plasma cell disorders are caused by both cytogenetic abnormalities and oncogene mutations. Therefore, it is necessary to detect molecular abnormalities to improve the diagnosis and management of MM. The main purpose of this study is to determine whether NGS, in addition to cytogenetics, can influence risk stratification and management. Additionally, we aim to establish whether mutational analysis of the CD138 cell population is a suitable option for the characterization of MM compared to the bulk population. Following the separation of the plasma cells harvested from 35 patients newly diagnosed with MM, we performed a FISH analysis to detect the most common chromosomal abnormalities. Consecutively, we used NGS to evaluate NRAS, KRAS, BRAF, and TP53 mutations in plasma cell populations and in bone marrow samples. NGS data showed that sequencing CD138 cells provides a more sensitive approach. We identified several variants in BRAF, KRAS, and TP53 that were not previously associated with MM. Considering that the presence of somatic mutations could influence risk stratification and therapeutic approaches of patients with MM, sensitive detection of these mutations at diagnosis is essential for optimal management of MM.
Translation into Clinical Practice of the G1-G7 Molecular Subgroup Classification of Glioblastoma: Comprehensive Demographic and Molecular Pathway Profiling
Authors: Georgescu Maria-Magdalena
Published: January 2024

Glioblastoma is the most frequent and malignant primary neoplasm of the central nervous system. In a recent breakthrough study on a prospective Discovery cohort, I proposed the first all-inclusive molecular classification of glioblastoma into seven subgroups, G1-G7, based on MAPK pathway activation. New data from a WHO-grade-4 diffuse glioma prospective Validation cohort offers, in this study, an integrated demographic–molecular analysis of a 213-patient Combined cohort. Despite cohort differences in the median age and molecular subgroup distribution, all the prospectively-acquired cases from the Validation cohort mapped into one of the G1-G7 subgroups defined in the Discovery cohort. A younger age of onset, higher tumor mutation burden and expanded G1/EGFR-mutant and G3/NF1 glioblastoma subgroups characterized the glioblastomas from African American/Black relative to Caucasian/White patients. The three largest molecular subgroups were G1/EGFR, G3/NF1 and G7/Other. The fourth largest subgroup, G6/Multi-RTK, was detailed by describing a novel gene fusion ST7–MET, rare PTPRZ1–MET, LMNA–NTRK1 and GOPC–ROS1 fusions and their overexpression mechanisms in glioblastoma. The correlations between the MAPK pathway G1-G7 subgroups and the PI3-kinase/PTEN, TERT, cell cycle G1 phase and p53 pathways defined characteristic subgroup pathway profiles amenable to personalized targeted therapy. This analysis validated the first all-inclusive molecular classification of glioblastoma, showed significant demographic and molecular differences between subgroups, and provided the first ethnic molecular comparison of glioblastoma.
Chondrosarcoma of the Femur: Is Local Recurrence Influenced by the Presence of an Extraosseous Component?
Authors: Laitinen Minna K. , Parry Michael C. , Morris Guy V. , Grimer Robert J. , Sumathi Vaiyapuri , Stevenson Jonathan D. , Jeys Lee M.
Published: January 2024

Background: Chondrosarcoma (CS) is the second most common surgically treated primary malignancy of the bone. The current study explored the effect of the margin and extraosseous tumor component in CS in the femur on local recurrence (LR), LR-free survival (LRFS), and disease-specific survival (DSS). Methods: Among 202 patients, 115 were in the proximal extremity of the femur, 4 in the corpus of the femur, and 83 in the distal extremity of femur; 105 patients had an extraosseous tumor component. Results: In the Kaplan–Meier analysis, factors significant for decreased LRFS were the extraosseous tumor component (p < 0.001), extraosseous tumor component arising from the superior aspect (p < 0.001), histological grade (p = 0.031), and narrow surgical margin < 3 mm (p < 0.001). Factors significantly affecting DSS were the histological grade (p < 0.001), extraosseous component (p < 0.001), LR (p < 0.001), metastases (p < 0.001), and surgical margin (p < 0.001). Conclusions: In CS of the femur, the presence of an extraosseous tumor component has a predictive role in LRFS, and extraosseous tumor component arising from the superior aspect was significant for decreased LRFS. Wide margins were more commonly achieved when the tumor had only an intraosseous component, and the rate of LR was significantly higher in cases with an extraosseous tumor component. When the extraosseous component arose from the superior aspect of the femur, LR occurred more frequently despite achieving adequate margins.
Iron Overload in Children with Acute Lymphoblastic and Acute Myeloblastic Leukemia—Experience of One Center
Authors: Sawicka-Zukowska Malgorzata , Kretowska-Grunwald Anna , Kania Agnieszka , Topczewska Magdalena , Niewinski Hubert , Bany Marcin , Grubczak Kamil , Krawczuk-Rybak Maryna
Published: January 2024

Transfusions of packed red blood cells (PRBCs), given due to an oncological disease and its acute complications, are an indispensable part of anticancer therapy. However, they can lead to post-transfusion iron overload. The study aim was to evaluate the role of ferritin as a nonspecific marker of leukemic growth and marker of transfusion-related iron overload. We performed a longitudinal study of PRBC transfusions and changes in ferritin concentrations during the oncological treatment of 135 patients with childhood acute lymphoblastic and acute myeloblastic leukemia (ALL and AML, median age 5.62 years). At the diagnosis, 41% of patients had a ferritin level over 500 ng/mL, and 14% of patients had a ferritin level over 1000 ng/mL. At the cessation of the treatment, 80% of the children had serum ferritin (SF) over 500 ng/mL, and 31% had SF over 1000 ng/mL. There was no significant difference between SF at the beginning of the treatment between ALL and AML patients, but children with AML finished treatment with statistically higher SF. AML patients had also statistically higher number of transfusions. We found statistically significant positive correlations between ferritin and age, and weight and units of transfused blood. Serum ferritin at the moment of diagnosis can be a useful marker of leukemic growth, but high levels of SF are connected with iron overload in both AML and ALL.
Efficacy of Different Oncolytic Vaccinia Virus Strains for the Treatment of Murine Peritoneal Mesothelioma
Authors: Yurttas Can , Beil Julia , Berchtold Susanne , Smirnow Irina , Kloker Linus D. , Sipos Bence , Löffler Markus W. , Königsrainer Alfred , Mihaljevic André L. , Lauer Ulrich M. , Thiel Karolin
Published: January 2024

Effective treatment options for peritoneal surface malignancies (PSMs) are scarce. Oncolytic virotherapy with recombinant vaccinia viruses might constitute a novel treatment option for PSM. We aimed to identify the most effective oncolytic vaccinia virus strain in two murine mesothelioma cell lines and the oncolytic potential in a murine model of peritoneal mesothelioma. Cell lines AB12 and AC29 were infected in vitro with vaccinia virus strains Lister (GLV-1h254), Western Reserve (GLV-0b347), and Copenhagen (GLV-4h463). The virus strain GLV-0b347 was shown most effective in vitro and was further investigated by intraperitoneal (i.p.) application to AB12 and AC29 mesothelioma-bearing mice. Feasibility, safety, and effectiveness of virotherapy were assessed by evaluating the peritoneal cancer index (PCI), virus detection in tumor tissues and ascites, virus growth curves, and comparison of overall survival. After i.p. injection of GLV-0b347, virus was detected in both tumor cells and ascites. In comparison to mock-treated mice, overall survival was significantly prolonged, ascites was less frequent and PCI values declined. However, effective treatment was only observed in animals with limited tumor burden at the time point of virus application. Nonetheless, intraperitoneal virotherapy with GLV-0b347 might constitute a novel therapeutic option for the treatment of peritoneal mesothelioma. Additional treatment modifications and combinational regimes will be investigated to further enhance treatment efficacy.
Multi-Algorithm Analysis Reveals Pyroptosis-Linked Genes as Pancreatic Cancer Biomarkers
Authors: Wang Kangtao , Han Shanshan , Liu Li , Zhao Lian , Herr Ingrid
Published: January 2024

Pancreatic ductal adenocarcinoma (PDAC) is often diagnosed at late stages, limiting treatment options and survival rates. Pyroptosis-related gene signatures hold promise as PDAC prognostic markers, but limited gene pools and small sample sizes hinder their utility. We aimed to enhance PDAC prognosis with a comprehensive multi-algorithm analysis. Using R, we employed natural language processing and latent Dirichlet allocation on PubMed publications to identify pyroptosis-related genes. We collected PDAC transcriptome data (n = 1273) from various databases, conducted a meta-analysis, and performed differential gene expression analysis on tumour and non-cancerous tissues. Cox and LASSO algorithms were used for survival modelling, resulting in a pyroptosis-related gene expression-based prognostic index. Laboratory and external validations were conducted. Bibliometric analysis revealed that pyroptosis publications focus on signalling pathways, disease correlation, and prognosis. We identified 357 pyroptosis-related genes, validating the significance of BHLHE40, IL18, BIRC3, and APOL1. Elevated expression of these genes strongly correlated with poor PDAC prognosis and guided treatment strategies. Our accessible nomogram model aids in PDAC prognosis and treatment decisions. We established an improved gene signature for pyroptosis-related genes, offering a novel model and nomogram for enhanced PDAC prognosis.
Correction: Reddy et al. Rlip Reduction Induces Oxidative Stress and Mitochondrial Dysfunction in Mutant Tau-Expressed Immortalized Hippocampal Neurons: Mechanistic Insights. Cells 2023, 12, 1646
Authors: Reddy P. Hemachandra , Kshirsagar Sudhir , Bose Chhanda , Pradeepkiran Jangampalli Adi , Hindle Ashly , Singh Sharda P. , Reddy Arubala P. , Baig Javaria
Published: January 2024

The authors wish to make the following changes to their paper [...]
Trodusquemine (MSI-1436) Restores Metabolic Flexibility and Mitochondrial Dynamics in Insulin-Resistant Equine Hepatic Progenitor Cells (HPCs)
Authors: Qasem Badr , Dąbrowska Agnieszka , Króliczewski Jarosław , Łyczko Jacek , Marycz Krzysztof
Published: January 2024

Equine metabolic syndrome (EMS) is a significant global health concern in veterinary medicine. There is increasing interest in utilizing molecular agents to modulate hepatocyte function for potential clinical applications. Recent studies have shown promising results in inhibiting protein tyrosine phosphatase (PTP1B) to maintain cell function in various models. In this study, we investigated the effects of the inhibitor Trodusquemine (MSI-1436) on equine hepatic progenitor cells (HPCs) under lipotoxic conditions. We examined proliferative activity, glucose uptake, and mitochondrial morphogenesis. Our study found that MSI-1436 promotes HPC entry into the cell cycle and protects them from palmitate-induced apoptosis by regulating mitochondrial dynamics and biogenesis. MSI-1436 also increases glucose uptake and protects HPCs from palmitate-induced stress by reorganizing the cells’ morphological architecture. Furthermore, our findings suggest that MSI-1436 enhances 2-NBDG uptake by increasing the expression of SIRT1, which is associated with liver insulin sensitivity. It also promotes mitochondrial dynamics by modulating mitochondria quantity and morphotype as well as increasing the expression of PINK1, MFN1, and MFN2. Our study provides evidence that MSI-1436 has a positive impact on equine hepatic progenitor cells, indicating its potential therapeutic value in treating EMS and insulin dysregulation.
Cardioprotective Effects of Hydrogen Sulfide and Its Potential Therapeutic Implications in the Amelioration of Duchenne Muscular Dystrophy Cardiomyopathy
Authors: Łoboda Agnieszka , Dulak Józef
Published: January 2024

Hydrogen sulfide (H2S) belongs to the family of gasotransmitters and can modulate a myriad of biological signaling pathways. Among others, its cardioprotective effects, through antioxidant, anti-inflammatory, anti-fibrotic, and proangiogenic activities, are well-documented in experimental studies. Cardiorespiratory failure, predominantly cardiomyopathy, is a life-threatening complication that is the number one cause of death in patients with Duchenne muscular dystrophy (DMD). Although recent data suggest the role of H2S in ameliorating muscle wasting in murine and Caenorhabditis elegans models of DMD, possible cardioprotective effects have not yet been addressed. In this review, we summarize the current understanding of the role of H2S in animal models of cardiac dysfunctions and cardiac cells. We highlight that DMD may be amenable to H2S supplementation, and we suggest H2S as a possible factor regulating DMD-associated cardiomyopathy.
Evaluating Adherence to Therapeutic Drug Monitoring Guidelines for Gentamicin in Neonatal Care: A Retrospective Study at the Maternity and Children’s Hospital in Makkah
Authors: Bajaber Abdullah Najeh , Elrggal Mahmoud , Organji Wajdi F. , Sulaimani Mohammad Adil , Refai Raed Mohammed , Alsaedi Ashraf , Alzamzami Salwa Hashim , Hawsawi Fatimah Bakor , Alnefaie Saud Tanadhub , Alsulaimani Azhar Ali , Alharbi Adnan , Alnuhait Mohammed , Alshammari Abdullah S. , Aldarhami Abdu , Sharaf Sharaf E.
Published: January 2024

In this study, we assess healthcare providers’ adherence to therapeutic drug monitoring (TDM) guidelines for gentamicin in neonates. Conducted at the Maternity and Children’s Hospital in Makkah, Saudi Arabia, from July 2020 to July 2022, it retrospectively analyzed the compliance of healthcare workers in managing neonates treated with gentamicin. Covering 410 neonates, primarily diagnosed with respiratory distress (56%) and sepsis (32%), the study revealed that while a majority of trough and peak levels conformed to guidelines, substantial deviations were noted in cases of respiratory distress. This underlines the necessity for targeted TDM strategies, particularly in managing respiratory distress in neonates, to ensure optimal treatment efficacy and safety. The findings urge stringent compliance with TDM guidelines, emphasizing personalized approaches in neonatal gentamicin therapy for improved healthcare outcomes.
Segregation of Phosphorus and Silicon at the Grain Boundary in Bcc Iron via Machine-Learned Force Fields
Authors: Černý Miroslav , Šesták Petr
Published: January 2024

The study of the effects of impurity on grain boundaries is a critical aspect of materials science, particularly when it comes to understanding and controlling the properties of materials for specific applications. One of the related key issues is the segregation preference of impurity atoms in the grain boundary region. In this paper, we employed the on-the-fly machine learning to generate force fields, which were subsequently used to calculate the segregation energies of phosphorus and silicon in bcc iron containing the ∑5(310)[001] grain boundary. The generated force fields were successfully benchmarked using ab initio data. Our further calculations considered impurity atoms at a number of possible interstitial and substitutional segregation sites. Our predictions of the preferred sites agree with the experimental observations. Planar concentration of impurity atoms affects the segregation energy and, moreover, can change the preferred segregation sites.
A Self-Powered Broadband Photodetector with High Photocurrent Based on Ferroelectric Thin Film Using Energy Band Structure Design
Authors: Gao Xing , Song Xin , Zhang Shan , Yang Xinxiang , Han Pei , Zhang Liwen , Lu Chunxiao , Hao Xihong , Li Yong
Published: January 2024

Self-powered photodetectors have the advantages of high sensitivity, sustainability, and small size and have become a research hotspot in advanced optoelectronic systems. However, the low output photocurrent density seriously hinders the practical application of ferroelectric self-powered photodetectors. Herein, the high-efficiency photoelectric detection performance of the Bi1-xHoxFeO3 ferroelectric self-powered photodetector is realized by doping Ho. The responsivity (R) and detectivity (D*) can reach 0.0159 A/W and 1.94 × 1011 Jones under monochromatic light with a wavelength of 900 nm. Meanwhile, the R and D* can reach 0.022 A/W and 2.65 × 1011 Jones under sunlight. These excellent photodetection performances are attributed to the high short-circuit current density (Jsc). When the Ho content is 6%, the output photocurrent reaches up to 0.81 mA/cm2. The systematic structure and photo-electric characteristic analysis suggest that the decrease in the band gap leads to the generation of a larger photocurrent while the ferroelectric polarization is reduced slightly. This work provides a new way to obtain high-performance self-powered photodetectors.
Gemological and Chemical Characterization of Gem-Quality Titanite from Morocco
Authors: Yuan Yu , Miao Zhuang , Zhao Yi , Xu Bo , Gu Jialu , Yuan Pengyu
Published: January 2024

Titanite is a widespread accessory mineral in igneous, metamorphic, and hydrothermal rocks, but few comply with gem-grade requirements. Previous studies on Moroccan titanite focused on elementary composition and U-Pb dating. In this study, two gem-grade titanites (MA-1 and MA-2) from the Moroccan Central High Atlas were investigated through gemological and chemical studies, including infrared spectrum, Raman spectrum, SEM-EDS, and LA-ICP-MS. Two titanite samples are yellow, transparent–translucent with a greasy luster, 3.5 and 2.5 mm long. MA-1 and MA-2 have similar gemological properties, the refractive index (RI) is beyond the range of the refractometer (>1.78), the specific gravity (SG) values fall in the range of 3.52~3.54 and both are inert to short-wave and long-wave UV radiation. The spectral characteristics have high consistency with the RRUFF database. The major elements’ composition shows a negative correlation between Al, Fe, V, and Ti, suggesting the titanites underwent substitutions such as (Al, Fe3+) + (F, OH) ↔ Ti + O. The titanite samples, characterized by a low abundance of REE (802~4088 ppm) and enriched in LREE, exhibit positive Eu (δEu: 1.53~7.79) and Ce (δCe: 1.08~1.33) anomalies, indicating their formation in a hydrothermal environment with low oxygen fugacity. The 238U/206Pb and 207Pb/206Pb ratios of the titanites yield lower intercept ages of 152.6 ± 2.2 and 151.4 ± 5.3 Ma (1s), consistent with their weighted average 206Pb/238U ages of 152.3 ± 2.0 and 150.7 ± 3.2 Ma (1s) respectively. The results of U-Pb dating are matched with the second main magmatic activities in the High Atlas intracontinental belt of Morocco during the Mesozoic to Cenozoic period. Moreover, the two titanite samples have almost no radiational damage. All the results show that the titanite from High Atlas, Morocco, has the potential to be a reference material for LA-ICP-MS U–Pb dating, but further experiments are needed to be sure.
End-of-Life Care Preferences of Patients with Advanced Urological Malignancies: An Explorative Survey Study at a Tertiary Referral Center
Authors: Volberg Christian , Urhahn Fabian , Pedrosa Carrasco Anna J. , Morin Astrid , Gschnell Martin , Huber Johannes , Flegar Luka , Heers Hendrik
Published: January 2024

Background: Many people want to die at home, but it is often not possible because they do not share their wishes with family members. This study was conducted to find out the extent to which patients with advanced urological malignancies had wishes regarding their final stage of life, made arrangements accordingly, and communicated their wishes to relatives and health care professionals. Methods: We conducted a survey among advanced urological tumor patients during their clinic visit at a German university hospital using a 31-item questionnaire. Inclusion criteria were metastatic or irresectable prostate cancer, urothelial carcinoma, or renal cell carcinoma. Results: In total, 88 patients (76 male, 12 female) completed the questionnaire, and 62 of those respondents (70%) had received their tumor diagnosis within the past 5 years. Symptoms were reported by 80%, and 18% described five or more symptoms. The majority (88%) stated that they had thought about their preferred place of death but 58% had not informed anyone about it. The preference for a hospice as the place of death correlated statistically significantly with the absence of a domestic partnership (p = 0.001) or marriage (p < 0.001) and with a high number of symptoms (≥5; p = 0.009). However, 73% had not talked with their urological oncologist about care options in case their health deteriorated though 36% of those were interested in having a conversation about it. Conclusions: Our results showed that 9 out of 10 patients reflected on their preferred place of death but only a few discussed it with anyone. Based on this finding, physicians and healthcare staff should initiate discussions about early care planning so that patients in incurable situations can express their wishes regarding their preferred place of death.
Diversity of Quill Mites of the Family Syringophilidae (Acariformes: Prostigmata) Parasitizing Starlings of the Genus Lamprotornis (Passeriformes: Sturnidae)
Authors: Skoracki Maciej , Patan Milena , Unsoeld Markus , Hromada Martin , Kwieciński Zbigniew , Marcisova Iva
Published: January 2024

Quill mites of the family Syringophilidae (Acariformes: Prostigmata) parasitizing starlings of the genus Lamprotornis Temminck (Aves: Passeriformes: Sturnidae) from the sub-Saharan region are comprehensively studied for the first time. Among them, two new species are described: (1) Syringophiloidus soponai Skoracki, Patan and Unsoeld sp. n., collected from four host species—Lamprotornis chalybaeus (Hemprich et Ehrenberg) (type host) in Kenya, Tanzania, and Ethiopia; L. superbus (Rüppell) in Kenya and Tanzania; L. chloropterus (Swainson) and L. unicolor (Shelley) both in Tanzania; (2) Syringophilopsis parasturni Skoracki, Patan and Unsoeld sp. n. collected from L. pulcher (Müller) and L. chalcurus (Nordmann), both in Senegal. Additionally, two Lamprotornis species, L. chalybaeus in Tanzania and Kenya and L. chloropterus in Kenya, are recorded as the new hosts for Picobia lamprotornis Klimovicova et al., 2004. We also discussed the diversity of the syringophilid mites associated with starlings.
Plant Diversity Distribution along an Urbanization Gradient and Relationships with Environmental Factors in Urban Agglomerations of Henan Province, China
Authors: Qi Rui , Zhou Xiayan , Li Zihao , Ye Yongzhong , Yuan Zhiliang , Liu Fengqin , Shao Yizhen , Wei Dongwei , Chen Yun
Published: January 2024

Urbanization induces rapid plant environmental modifications, leading to alterations in plant diversity distribution patterns and plant homogenization. However, how plant diversity is distributed along urbanization gradients in regional urban agglomerations and its relationship with environmental factors are not well defined. In three nearby Henan Province Chinese cities—Zhengzhou, Kaifeng, and Zhongmu—along an urbanization gradient, the distribution pattern of plant diversity was quantified. Both native and non-native plants found in urban green spaces were taken into consideration. A total of 176 plant quadrats were selected and separated into three urbanization gradient types using space-constrained hierarchical clustering: urban core, urban suburb, and urban outskirt. Polynomial fitting was used to characterize the spatial distribution patterns of plants along the urbanization gradient, and Pearson correlation and the Mantel test were employed to examine the effects of environmental factors, including longitude, latitude, altitude, distance from the urban center, temperature, and illumination, on plant diversity. A total of 313 vascular plant species, comprising 137 woody species and 176 herbaceous species, were examined. Along the three urbanization gradients, remarkable variations in plant diversity for woody and herbaceous species were observed. The spatial patterns of plant diversity were consistent across cities, whereas woody plants and herbaceous plants displayed the opposite behavior. Distance to the city center and temperature were the most substantial environmental effect factors for the diversity of woody plants, whereas light factors had a major impact on herbaceous plants. These findings show different life-type plants are affected differently by urbanization, and they offer managers and planners a recommendation for increasing urban plant diversity by executing various interventions throughout the urban gradient.
Reappraisal of the Identity of Batrachium pekinense (Ranunculaceae) and Its Implication for Biodiversity Conservation and Management
Authors: Mu Xian-Yun , Gu Han-Ze , Yu Han , Dong Wen-Guang , Liang Tie-Shuang
Published: January 2024

Because of human-induced habitat deterioration and climate change, a large number of species are threatened and even endangered. Batrachium pekinense Liang Liu, a perennial aquatic plant endemic to Beijing, was synonymized as a widely distributed species in Northern China, B. bungei Steudel, but it was later listed in the national key protected wild plants in China. Taxonomic uncertainty should be clarified especially when related species may be allocated with a limited conservation budget. In this study, we reappraised the identity of B. pekinense based on results from molecular phylogenetic analysis and 15-year field observations. Our result shows that 77% of the 65 individuals collected from various sites share identical sequences in both the nuclear ribosomal ITS and the plastid psbA-trnH markers, all samples of the two species consist of one monophyletic clade with strong support, and continuous morphological variations on the key distinguishing character, the leaf shape, are observed in the field. Integrative evidence from both our and the others’ studies supports the same identity for B. pekinense and B. bungei. Hence, we suggest excluding B. pekinense from the list of national key protected wild plants of China in its next update and advocate the integrative evidence-based taxonomy and systematics for biodiversity conservation and management.
Cross Entropy in Deep Learning of Classifiers Is Unnecessary—ISBE Error Is All You Need
Authors: Skarbek Władysław
Published: January 2024

In deep learning of classifiers, the cost function usually takes the form of a combination of SoftMax and CrossEntropy functions. The SoftMax unit transforms the scores predicted by the model network into assessments of the degree (probabilities) of an object’s membership to a given class. On the other hand, CrossEntropy measures the divergence of this prediction from the distribution of target scores. This work introduces the ISBE functionality, justifying the thesis about the redundancy of cross-entropy computation in deep learning of classifiers. Not only can we omit the calculation of entropy, but also, during back-propagation, there is no need to direct the error to the normalization unit for its backward transformation. Instead, the error is sent directly to the model’s network. Using examples of perceptron and convolutional networks as classifiers of images from the MNIST collection, it is observed for ISBE that results are not degraded with SoftMax only but also with other activation functions such as Sigmoid, Tanh, or their hard variants HardSigmoid and HardTanh. Moreover, savings in the total number of operations were observed within the forward and backward stages. The article is addressed to all deep learning enthusiasts but primarily to programmers and students interested in the design of deep models. For example, it illustrates in code snippets possible ways to implement ISBE functionality but also formally proves that the SoftMax trick only applies to the class of dilated SoftMax functions with relocations.
A Quantum Double-or-Nothing Game: An Application of the Kelly Criterion to Spins
Authors: Meister Bernhard K. , Price Henry C. W.
Published: January 2024

A quantum game is constructed from a sequence of independent and identically polarised spin-1/2 particles. Information about their possible polarisation is provided to a bettor, who can wager in successive double-or-nothing games on measurement outcomes. The choice at each stage is how much to bet and in which direction to measure the individual particles. The portfolio’s growth rate rises as the measurements are progressively adjusted in response to the accumulated information. Wealth is amassed through astute betting. The optimal classical strategy is called the Kelly criterion and plays a fundamental role in portfolio theory and consequently quantitative finance. The optimal quantum strategy is determined numerically and shown to differ from the classical strategy. This paper contributes to the development of quantum finance, as aspects of portfolio optimisation are extended to the quantum realm. Intriguing trade-offs between information gain and portfolio growth are described.
Study on Microstructure and High Temperature Stability of WTaVTiZrx Refractory High Entropy Alloy Prepared by Laser Cladding
Authors: Ding Xiaoyu , Wang Weigui , Zhang Haojie , Tian Xueqin , Luo Laima , Wu Yucheng , Yao Jianhua
Published: January 2024

The extremely harsh environment of the high temperature plasma imposes strict requirements on the construction materials of the first wall in a fusion reactor. In this work, a refractory alloy system, WTaVTiZrx, with low activation and high entropy, was theoretically designed based on semi-empirical formula and produced using a laser cladding method. The effects of Zr proportions on the metallographic microstructure, phase composition, and alloy chemistry of a high-entropy alloy cladding layer were investigated using a metallographic microscope, XRD (X-ray diffraction), SEM (scanning electron microscope), and EDS (energy dispersive spectrometer), respectively. The high-entropy alloys have a single-phase BCC structure, and the cladding layers exhibit a typical dendritic microstructure feature. The evolution of microstructure and mechanical properties of the high-entropy alloys, with respect to annealing temperature, was studied to reveal the performance stability of the alloy at a high temperature. The microstructure of the annealed samples at 900 °C for 5–10 h did not show significant changes compared to the as-cast samples, and the microhardness increased to 988.52 HV, which was higher than that of the as-cast samples (725.08 HV). When annealed at 1100 °C for 5 h, the microstructure remained unchanged, and the microhardness increased. However, after annealing for 10 h, black substances appeared in the microstructure, and the microhardness decreased, but it was still higher than the matrix. When annealed at 1200 °C for 5–10 h, the microhardness did not increase significantly compared to the as-cast samples, and after annealing for 10 h, the microhardness was even lower than that of the as-cast samples. The phase of the high entropy alloy did not change significantly after high-temperature annealing, indicating good phase stability at high temperatures. After annealing for 10 h, the microhardness was lower than that of the as-cast samples. The phase of the high entropy alloy remained unchanged after high-temperature annealing, demonstrating good phase stability at high temperatures.
Using Generative Artificial Intelligence Tools to Explain and Enhance Experiential Learning for Authentic Assessment
Authors: Salinas-Navarro David Ernesto , Vilalta-Perdomo Eliseo , Michel-Villarreal Rosario , Montesinos Luis
Published: January 2024

The emergence of generative artificial intelligence (GenAI) requires innovative educational environments to leverage this technology effectively to address concerns like academic integrity, plagiarism, and others. Additionally, higher education needs effective pedagogies to achieve intended learning outcomes. This emphasizes the need to redesign active learning experiences in the GenAI era. Authentic assessment and experiential learning are two possible meaningful alternatives in this context. Accordingly, this article investigates how GenAI can enhance teaching and learning by constructively addressing study situations beyond conventional learning approaches and cultivating high-order skills and knowledge acquisition. This study employs thing ethnography to examine GenAI tools’ integration with authentic assessment and experiential learning and explore implementation alternatives. The results reveal insights into creating human-centered and GenAI-enhanced learning experiences within a constructive alignment. Specific examples are also provided to guide their implementation. Our contributions extend beyond the traditional use of GenAI tools as mere agents-to-write or agents-to-answer questions to become agents-to-support experiential learning for authentic assessment. These findings underscore the transformative role of GenAI tools in enhancing teaching and learning efficacy and effectiveness. The limitations in treating GenAI tools as subjects in thing ethnography are acknowledged, with potential for future implementation evaluation.
Automated Over-the-Top Service Copyright Distribution Management System Using the Open Digital Rights Language
Authors: Son Wooyoung , Kwon Soonhong , Oh Sungheun , Lee Jong-Hyouk
Published: January 2024

As the demand and diversity of digital content increase, consumers now have simple and easy access to digital content through Over-the-Top (OTT) services. However, the rights of copyright holders remain unsecured due to issues with illegal copying and distribution of digital content, along with unclear practices in copyright royalty settlements and distributions. In response, this paper proposes an automated OTT service copyright distribution management system using the Open Digital Rights Language (ODRL) to safeguard the rights of copyright holders in the OTT service field. The proposed system ensures that the rights to exercise copyright transactions and agreements, such as trading of copyright, can only be carried out when all copyright holders of a single digital content agree based on the Threshold Schnorr Digital Signature. This approach takes into account multiple joint copyright holders, thereby safeguarding their rights. Furthermore, it ensures fair and transparent distribution of copyright royalties based on the ratio information outlined in ODRL. From the user’s perspective, the system not only provides services proactively based on the rights information specified in ODRL, but also employs zero-knowledge proof technology to handle sensitive information in OTT service copyright distribution, thereby addressing existing privacy concerns. This approach not only considers joint copyright holders, but also demonstrates its effectiveness in resolving prevalent issues in current OTT services, such as illegal digital content replication and distribution, and the unfair settlement and distribution of copyright royalties. Applying this proposed system to the existing OTT services and digital content market is expected to lead to the revitalization of the digital content trading market and the establishment of an OTT service environment that guarantees both vitality and reliability.
Development of an Adaptive Fuzzy-Neural Controller for Temperature Control in a Brick Tunnel Kiln
Authors: Phan Van Du , Nguyen Xuan Hung , Dinh Van Nam , Dang Thai Son , Le Van Chuong , Ho Sy Phuong , Ta Hung Cuong , Duong Dinh Tu , Mai The Anh
Published: January 2024

This research focuses on developing an adaptive fuzzy-neural control system to manage and maintain temperature in brick tunnel kilns. The problem is how to optimize performance and energy consumption in the brick production process. A control algorithm using a combination of a fuzzy logic system and neural network is proposed to automatically adjust temperature parameters, optimize production efficiency, and reduce energy consumption. Simulation and experimental results demonstrate the outstanding performance of the presented system, with significant improvements in energy efficiency and product quality compared to traditional control methods. Moreover, the obtained results exhibit the potential for wide application of the adaptive neuro-fuzzy control method in academic study or industrial production processes.
Promising Abilities of Fungal Lipases of Aspergilli Strains in the Production of Biodiesel from Plant Oil Wastes
Authors: Al-Anazi Norah A. , Alabdalall Amira H. , Alsoufi Maryam H. , Al-Ghamdi Azza , Aldakheel Fatimah A.
Published: January 2024

Currently, there exists a significant need for alternate sources of petroleum fuel due to escalating environmental challenges and diminishing global oil reserves. Biodiesel, an environmentally friendly and sustainable fuel, is one of the most adaptable alternatives to petroleum fuel. This study’s goals were to get biodiesel from three oils (olive, palm, and jojoba) and see how well lipases work as biocatalysts for the esterification process. The production of biodiesel was obtained from two fungal strains, Aspergillus niger MH079049.1 and A. niger MH078571.1, and four distinct fatty acids and four organic solvents were used. The study determined the optimal reaction conditions to be a reaction time of 24 h, an enzyme concentration of 3 mL, and an oil-to-methanol ratio of 3:1. This study showed that lipase works well in making biodiesel, with an impressive esterification yield of 99%, and the highest level of productivity was attained when olive oil and jojoba oils were subjected to an incubation time of 18 h and 22 h, respectively, in the presence of palm oil.