bluuebunny/crossref_metadata_2025 huggingface dataset:
Spanish–English Cross-Linguistic Influence on Heritage Bilinguals’ Production of Uptalk
Authors: Kim Ji Young
Published: January 2023

The present study examines the production of uptalk in Spanish and in English by Spanish heritage speakers in Southern California. Following the L2 Intonation Learning Theory, we propose that cross-linguistic influence in heritage bilinguals’ uptalk may occur along multiple dimensions of intonation. In this study, we examined the systemic dimension (i.e., presence of uptalk and presence of uptalk with IP-final deaccenting), the frequency dimension (i.e., frequency of uptalk and frequency of uptalk with IP-final deaccenting), and the realizational dimension (i.e., pitch excursion and rise duration) of heritage bilinguals’ uptalk. Our data showed that the three dimensions of intonation demonstrate varying degrees of cross-linguistic influence. The heritage bilinguals produced uptalk with IP-final deaccenting in both languages (i.e., systemic dimension), but produced it more in English than in Spanish (i.e., frequency dimension). That is, IP-final deaccenting emerges in heritage bilinguals’ uptalk in Spanish, but heritage bilinguals seem to recognize that this is an English feature that is not allowed in Spanish and try to suppress it as much as possible when producing uptalk in Spanish. However, in the realizational dimension, the heritage bilinguals demonstrated either phonetic assimilation to English (i.e., pitch excursion) or individual variability conditioned by language learning experience (i.e., rise duration). The asymmetry found across the dimensions suggests that, when bilinguals’ two languages are in competition for finite online resources, such as in the case of spontaneous speech production, phonological distinctions between L1 and L2 prosodic structures are kept, whereas phonetic differences that do not lead to any change in meaning are more prone to undergo cross-linguistic influence in order to reduce online processing cost. This study attempts to fill a gap in the literature on the cross-linguistic influence of intonation by bringing attention to heritage bilinguals. Heritage bilingualism introduces bilingual contexts that are often left unnoticed in traditional L2 acquisition scenarios (e.g., transfer from L2 to L1 intonation, asymmetry between order of acquisition and language dominance). Given that many aspects of cross-linguistic influence are shared across bilinguals, the investigation of heritage bilinguals’ intonation will contribute to building robust models of bilingual intonation.
Assessment of Headache Characteristics, Impact, and Managing Techniques among Pharmacy and Nursing Undergraduates—An Observational Study
Authors: Bashatah Adel S. , Syed Wajid , Al-Rawi Mahmood Basil A. , Al Arifi Mohamed N.
Published: January 2023

Background and Objectives: Many different forms of headaches can change or impact daily activity and quality of life, which increases the financial burden on society over time. Undergraduates who get headaches may be absent from attending lectures, perform less well on their daily tasks and academic achievement, as well as struggle to build and maintain relationships with peers and mentors. Therefore, this study aimed to assess the headache-related characteristics and managing approaches among Saudi pharmacy and nursing students at a Saudi university, in Riyadh, Saudi Arabia. Materials and Methods: A survey questionnaire was administered in this cross-sectional study to participants at a Saudi university, in Riyadh, Saudi Arabia. Participants included males. The sample size was calculated with Raosoft® software. Data analysis was executed using IBM Statistic SPSS, and the level of statistical significance was set at p < 0.05. Results: A total of 236 participants completed the questionnaires. The majority, i.e., 218 (92.4%) of them, were male; in addition, 124 (52.5%) were aged between 26 and 30, 124 (52.5%) were pharmacy students, 112 (47.5%) were nursing students, and 134 (56.8%) were smokers. When asked about ever having at least one episode of headache during the week, 66.1% (n = 156) agreed that they had one episode of headache, although 57 (24.2%) of the students had a headache for five days during a week. With regard to the impact of headaches on everyday activities, only 34.7% of the students said that headache disrupted their regular activities. Almost 41% of the students agreed that headache impacted their academic performance. Nearly 34% of students (n = 79) who had headaches considered napping, while 33% (n = 64) took painkillers and anti-inflammatory medicines, and 25% (n = 59) considered taking caffeine. In this study, the participants’ ages and headache severity were strongly associated (p = 0.0001). More pharmacy students (66.1%) reported having severe headaches than nursing students (14.3%) (p = 0.0001). Conclusions: The current findings revealed that most of the undergraduates suffered from headaches, and the intensity of the pain was moderate; furthermore, one in four undergraduates reported that headaches impacted their academic performance. Caffeine and simple analgesics and anti-inflammatories were used for headache relief.
Carbohydrate-Small Molecule Hybrids as Lead Compounds Targeting IL-6 Signaling
Authors: Schultz Daniel C. , Pan Li , Wang Tiffany , Booker Conner , Hyder Iram , Hanold Laura , Rubin Garret , Ding Yousong , Lin Jiayuh , Li Chenglong
Published: January 2023

In the past 25 years, a number of efforts have been made toward the development of small molecule interleukin-6 (IL-6) signaling inhibitors, but none have been approved to date. Monosaccharides are a diverse class of bioactive compounds, but thus far have been unexplored as a scaffold for small molecule IL-6-signaling inhibitor design. Therefore, in this present communication, we combined a structure-based drug design approach with carbohydrate building blocks to design and synthesize novel IL-6-signaling inhibitors targeting glycoprotein 130 (gp130). Of this series of compounds, LS-TG-2P and LS-TF-3P were the top lead compounds, displaying IC50 values of 6.9 and 16 µM against SUM159 cell lines, respectively, while still retaining preferential activity against the IL-6-signaling pathway. The carbohydrate moiety was found to improve activity, as N-unsubstituted triazole analogues of these compounds were found to be less active in vitro compared to the leads themselves. Thus, LS-TG-2P and LS-TF-3P are promising scaffolds for further development and study as IL-6-signaling inhibitors.
Immunoprofiling of Equine Plasma against Deinagkistrodon acutus in Taiwan: Key to Understanding Differential Neutralization Potency in Immunized Horses
Authors: Wu Cho-Ju , Liaw Geng-Wang , Chen Chun-Kuei , Ouyang Chun-Hsiang , Yang Yi-Xiu , Chu Li-Chieh , Hsiao Yung-Chin , Liu Chien-Hsin , Hsieh Wen-Chin , Wang Cyong-Yi , Liou Yu-Syuan , Liu Chien-Chun , Hsieh Cheng-Hsien
Published: January 2023

Snakebite envenoming is a public health issue linked to high mortality and morbidity rates worldwide. Although antivenom has been the mainstay treatment for envenomed victims receiving medical care, the diverse therapeutic efficacy of the produced antivenom is a major limitation. Deinagkistrodon acutus is a venomous snake that poses significant concern of risks to human life in Taiwan, and successful production of antivenom against D. acutus envenoming remains a considerable challenge. Among groups of horses subjected to immunization schedules, few or none subsequently meet the quality required for further scale-up harvesting. The determinants underlying the variable immune responses of horses to D. acutus venom are currently unknown. In this study, we assessed the immunoprofiles of high-potency and low-potency horse plasma against D. acutus venom and explored the conspicuous differences between these two groups. Based on the results of liquid chromatography with tandem mass spectrometry (LC-MS/MS), acutolysin A was identified as the major component of venom proteins that immunoreacted differentially with the two plasma samples. Our findings indicate underlying differences in antivenoms with variable neutralization efficacies, and may provide valuable insights for improvement of antivenom production in the future.
Meaningful Engagement of Persons Affected by Leprosy in Research: An Exploration of Its Interpretation, Barriers, and Opportunities
Authors: de Groot Laura , van ‘t Noordende Anna T. , Duck Mathias , Oraga Joshua , Rai Sarju Sing , Peters Ruth M. H. , Veldhuijzen Nienke
Published: January 2023

Despite the growing interest in public and patient involvement in research, best practices in the leprosy context have yet to be explored. This mixed-method study aimed to explore the interpretation, barriers and opportunities of meaningful engagement of persons affected by leprosy in research through: (i) an exploratory phase consisting of key informant interviews with experts in public and patient involvement (n = 2) and experts-by-experience (i.e., persons affected by leprosy; n = 4), and (ii) an in-depth phase among leprosy researchers consisting of an online survey (n = 21) and key informant interviews (n = 7). Qualitative data were thematically analyzed. Basic descriptive statistics were used to summarize the survey data. Key informant interviewees unanimously agreed to the importance of engagement in research. Survey results indicated that the level of engagement differed across research stages. Identified barriers included a lack of skills for or awareness of engagement among both experts-by-experience and researchers, stigma and limited time and resources. Opportunities included capacity strengthening, creating a shared understanding, building rapport, and establishing a safe environment. In conclusion, this exploratory study emphasized the importance of engagement of experts-by-experience in leprosy research and identified ways forward that include, but are not limited to, the acknowledgement of its value and creating a shared understanding.
URBAN TRANSPORT SYSTEM IMPROVEMENT BY THE MAIN TRENDS OF MOBILITY INTRODUCTION IN THE MASS EVENTS CONDITIONS
Authors:   Don State Technical University, Olga Yurievna Bulatova , Viacheslav Sergeevich Bulatov ,   Don State Technical University
Published: January 2023

This article discusses the main directions of development of transport infrastructure, allowing to create a sustainable transport system.
CALCULATION OF DISTRIBUTION DENSITY OF ANTI-ICE REAGENT BY A SINGLE NOZZLE OF AERODROME WATER WASHING MACHINE
Authors:   LLC «Zavod Spetsagregat», SubachevEvgeniy Vladimirovich Subachev , Dmitry Aleksandrovich Nikitin ,   Moscow Automobile and Road Construction State Tech-nical University (MADI), Vladimir Ssergeevich Ershov ,   Moscow Automobile and Road Construction State Tech-nical University (MADI), Alexey Andreevich Akulov ,   Moscow Automobile and Road Construction State Tech-nical University (MADI)
Published: January 2023

Within the framework of the proposed article, the key features of the operation of an airfield watering machine (APMM). The most efficient layout of the APMM, which is capable of having high operational and technical and economic indicators, has been revealed. The calculation of the probability of distribution of anti-icing reagent by one nozzle of an airfield watering machine was made. A certain flow rate of the medium liquid through one nozzle for a period of time. A certain optimal value of the stock of nozzles required of the required quality of spraying of water and a reagent to use the high-quality grip of the aircraft with the runway.
SIMULATION OF PASSENGER TRAFFIC DEPENDING ON CHANGES IN PASSENGER FLOW DURING THE YEAR
Authors:   Voronezh state forestry University, Vladimir Petrovich Belokurov , Ruslan Aleksandrovich Korablev ,   Voronezh state forestry University, Eduard Nikolaevich Busarin ,   Voronezh state forest engineering University, Eldar Yusufovich Guketlev ,   Maikop State Technological University
Published: January 2023

The article discusses the current state of the organization of passenger transportation, which has a number of common problems, the solution of which is very relevant. The instability of passenger flows during the year, which is especially typical for the cities of the South of Russia during the summer holidays, causes an urgent need to reorganize the process of managing transport processes through the use of optimization solutions. The greatest efficiency in this case can be achieved through the use of an optimal system for managing transport services for the population of cities while ensuring the quality of the transportation process.
ORGANIZATION OF SHARING PASSENGER TRANSPORTATION BY CARS ON LOW-INTENSITY ROUTES
Authors:   Russian University of transport, Sergey Petrovich Vakulenko , Andrej Stepanovich Kravcov ,   Moscow-Tver Suburban Passenger Company, Liliya Rinatovna Aysina ,   Russian University of transport, Artemit Pavlovich Ivanov ,   Russian University of transport
Published: January 2023

The authors of the article suggest using personal transport to perform public transport tasks for settlements, which are remote from the main transport. As rule, there are one or two bus trip per week in these settlements and the consumer quality of passenger service in most cases is poorly satisfactory. The article considers the foreign experience of organizing joint trips on low-intensity routes. The article describes the aspects of basing the concept of a new transport product and identifies areas for further scientific research.
FORECASTING CHANGES IN THE ENVIRONMENTAL PERFORMANCE OF A DIESEL ENGINE
Authors:   Tula State University, Mikhail Yurievich Elagin , Roman Nikolaevich Khmelev ,   Tula State University
Published: January 2023

In the article, on the basis of experimental data, the dependences of changes in the environmental indicators of diesel on the operating parameters are obtained. The research was carried out on the example of the TMZ-450D diesel engine. Concentrations of CO and NOx in exhaust gases were considered as environmental indicators. Examples of calculations are given. The results obtained make it possible to predict changes in the environmental performance of a diesel engine in order to find possible ways to improve them.
VALIDATION OF THE CAPACITY ESTIMATION MODEL FOR URBAN THREE-LANE TRAFFIC CIRCLES
Authors:   Irkutsk National Research Technical University, Navruz Mirzorakhimovich Karimov , Alexander Yuryevich Mikhaylov ,   Irkutsk National Research Technical University
Published: January 2023

Currently, three-lane traffic circles are widely used in cities of the Russian Federation. At the same time there are no methods for calculation of the capacity of such traffic circles, taking into account the peculiarities of traffic modes in urban conditions. The paper presents substantiation of development of a model for estimation of capacity of multilane roundabouts based on the conflict points. The development of such a model will allow to carry out a comparative analysis of the efficiency of multilane roundabouts with signalized roundabouts and turbo-roundabouts.
DEVELOPMENT OF AN ALGORITHM FOR ASSESSING THE EFFICIENCY OF COORDINATED MANAGEMENT
Authors:   Voronezh State Forest Engineering University, Alexander Yurievich Artemov , Sergey Vladimirovich Dorokhin ,   Voronezh State Forest Engineering University
Published: January 2023

The article considers one of the main ways to control the movement of traffic flows in cities - coordination, which is the movement of cars along the main street from «green» to «green». When such situations arise, the use of coordinated management should be justified, in connection with this, within the framework of the study, an algorithm was developed to evaluate the effectiveness of coordinated management based on the result of assessing traffic delays and traffic intensity.
FORMATION OF TECHNICAL REQUIREMENTS FOR THE INTELLIGENT LOCOMOTIVE SYSTEM
Authors:   Russian University of Transport (RUT (MIIT), Valery Nikolaevich Igin
Published: January 2023

The process of forming technical requirements for the intelligent system of a locomotive intended for operation at the Eastern landfill of the railways of the Russian Federation is considered. The list of basic functions for automatic locomotive control and diagnostics of its technical condition has been clarified.
Pengaruh Return On Equity, Current Ratio, Debt to Equity Ratio, dan Price Earning Ratio Terhadap Harga Saham
Authors: Sari Novia Puspita , Nuswandari Cahyani
Published: January 2023

The purpose of this research to examine the effect of the ratio of ROE, CR, DER, and PER on stock prices. In this study, the census method was used with the research model covering all manufacturing companies in the food and beverage sub-sector in Indonesia that were listed on the IDX in 2016-2020 period with documentation data collection techniques. Company data obtained from the Indonesia Stock Exchange (IDX) web. The analytical tool used is multiple regression. The result in this study indicate that the profitability ratio (ROE) has an effect and is significant on stock prices, while Liquidity (CR), Solvency (DER), PER (Price Earning Ratio) have no and no significant effect on stock prices.
Pengaruh Current Ratio (CR) dan Debt to Equity Ratio (DER) Terhadap Profitabilitas Pada Industri Terindeks LQ 45
Authors: Faujiah Rina , Nursito Nursito
Published: January 2023

Industries indexed by LQ 45 are industries that have a very large market capitalization value. This is what causes investors to compete to invest their shares in the LQ 45 indexed industry. Therefore, this study aims to see whether the Current Ratio and Debt to Equity Ratio have a contribution to profitability. In taking the sample using purposive sampling method with several criteria so as to get 6 samples of the manufacturing industry in the consumer goods sector. In analyzing the data using the classical assumption test, multiple linear regression analysis and hypothesis testing. The data obtained were obtained directly from the official website of each manufacturing industry in the consumer goods sector which was used as a sample in the form of the company's annual report. The results of this study partially show the current ratio has a significant contribution to profitability, the debt equity ratio also has a significant contribution to profitability. Simultaneously, the current ratio and debt equity ratio have a significant contribution to profitability of 54.8%. influenced by other factors not tested in this study.
Scapula ou Scaevola ? Sur l’identité du maître de cavalerie de 362
Authors: Lanfranchi Thibaud
Published: January 2023

À partir d’un réexamen de la documentation épigraphique et littéraire, cet article se propose de revenir sur l’identité du maître de cavalerie de l’année 362 avant J.-C. À rebours de l’hypothèse proposée en 1997 par R. T. Ridley, il entend démontrer qu’il est très compliqué d’en faire un Mucius Scaevola et qu’une lecture en Scapula est préférable.
Le plongeon des Hyperboréens, une pratique funéraire utopique
Authors: Voisin Corentin
Published: January 2023

Dans la tradition antique décrivant les Hyperboréens s’inscrivent deux passages de Pomponius Mela (III, 37) et Pline l’Ancien (IV, 89), qui livrent une description commune des rituels funéraires pratiqués chez ce peuple. L’individu décide de lui-même de mettre fin à ses jours en plongeant dans la mer du haut d’un rocher. Cette précipitation transgresse cependant toutes les normes funéraires grecques et romaines où le cadavre doit recevoir une sépulture. Les auteurs construisent donc une utopie totale où l’individu vit en harmonie avec la communauté jusque dans la mort qui n’implique ni cadavre ni tombe et donc aucune souillure.
Desenvolvimento de um sistema de correção automático de solução nutritiva em sistema hidropônico NFT utilizando microcontroladores de baixo custo
Authors: Carvalho Jéssica Eduarda Nery , Bonfim-Silva Edna Maria , Meneghetti Luana Aparecida Menegaz , da Silva Tonny José Araújo , De Oliveira Ronaldo Aparecido , Da Silva Tallys Henrique Bonfim
Published: January 2023

Há uma grande demanda pela cultura da alface, por apresentar um baixo custo e possuir excelentes qualidades nutricionais. O cultivo de hortaliças é um desafio, pois existem diversos fatores que influenciam em sua produção, entre eles, destaca-se o fator climático, devido à dificuldade de produção em períodos chuvosos. Uma das alternativas é o cultivo dessas culturas em ambientes protegidos e controlados, utilizando o sistema hidropônico. Umas das características na hidroponia é o cultivo sem solo, em que os nutrientes são fornecidos às plantas através de uma solução nutritiva. Nesse contexto, objetivou-se criar um sistema de correção automático de solução nutritiva em sistema hidropônico utilizando microcontroladores de baixo custo. A pesquisa foi desenvolvida na Universidade Federal de Rondonópolis-UFR, em casa de vegetação. Foi construído um protótipo de um sistema hidropônico constituído de uma bancada com perfis utilizando Policloreto de Vinila. O fluxo intermitente da solução nutritiva foi realizado através de uma bomba acionada em intervalos de cinco minutos. O pH e a condutividade elétrica da solução nutritiva foram controlados e monitorados através de um sensor resistivo e um de pH próprio para Arduíno. Com a instalação do sistema, foram inseridas mudas de alface crespa com 30 dias após emergência, em conjunto com a solução nutritiva, desenvolvendo-se até o final do ciclo de 45 dias dentro do sistema hidropônico. As variáveis analisadas foram área foliar, massa fresca e número de folhas. As plantas de alface desenvolveram-se adequadamente dentro do sistema hidropônico com correção automática de solução nutritiva.
Roda de conversa sobre o orgasmo feminino em uma Unidade Básica de Saúde: um relato de experiência
Authors: Lima Uirassú Tupinambá Silva de , Silva Maria José Ribeiro Sampaio , Oliveira Ingrid Alana dos Santos , Goes Samya Manoella Vieira de Vasconcelos
Published: January 2023

Introdução: A definição clássica do orgasmo feminino afirma que "consiste num pico sensorial variável e transitório de intenso prazer que cria um estado alterado de consciência, que começa com explosões de contracções involuntárias e rítmicas da musculatura pélvica estriada circunvaginal, com a presença concomitante de contracções uterinas e anais e miotonia Objetivo geral: relatar a experiência de uma roda de conversa sobre o orgasmo feminino na perspectiva de professores e estudantes de enfermagem em uma Unidade Básica de Saúde. Método:  Esta pesquisa narra um relato de experiência de um grupo de professores e estudantes de enfermagem na condução de uma roda de conversa feminina sobre o orgasmo, na qual se buscou oportunizar educação em saúde, acolhimento e escuta terapêutica. Resultados/Discussão: O orgasmo precisa ser tratado de maneira singular, pois cada mulher sente e vivencia esse momento de uma forma diferente, levando em consideração a realidade de cada uma. A relação entre o orgasmo e o bem-estar físico e mental foi nítido, na discussão do grupo.  Conclusão: As descobertas indicam que as mulheres diferem muito umas das outras em termos de como atingem o orgasmo, e em como descrevem tal sensação. O protagonismo da mulher na promoção do próprio prazer foi uma das barreiras desmistificadas durante a reunião, o que gerou empoderamento para o grupo.
A Study on the Positive Experiences of Participants in Gyeongju Cultural Heritage Exploration in the Midlife Transition Period: Focusing on competence in the Digital Age
Authors:   Korean Association of Regional Sociology, Shon Kang-Suk
Published: January 2023

The purpose of this study is to explore changes through the experiences and experiences of the middle-aged generation who participated in the Gyeongju cultural relic site tour, focusing on competence in the digital age. The research questions of this study are as follows. First, what kind of positive experiences did the generation in the middle-aged transition period have through the Gyeongju tour? Second, what did the generation in the middle-aged transition period gain from the experience of visiting Gyeongju? Third, how will the generation in the middle-aged transition period apply what they learned from their Gyeongju tour experience to their lives? For this purpose, six participants were interviewed and analyzed through the focus group interview method. The results of this study are expected to not only confirm the positive changes through the Gyeongju tour of the generation in the middle-aged transition period in the digital age, but also provide basic information for the development of programs for the generation in the middle-aged transition period to field experts.
Wawasan Moderasi Beragama Dalam Pengembangan Desain Pembelajaran Pendidikan Agama Islam
Authors: NAFA YORDAN , Sutomo Moh. , Mashudi Mashudi
Published: January 2023

Artikel ini membahas mengenai urgensi wawasan moderasi beragama dalam pengembangan desain pembelajaran Pendidikan Agama Islam. Moderasi beragama merupakan salah satu konsep dasar yang penting untuk dipahami peserta didik guna menumbuhkan nilai toleransi. Seorang guru Pendidikan Agama Islam memiliki peran penting dalam mendesain pembelajaran, agar nilai-nilai moderasi agama dapat tersampaikan dan terinternalisasi dengan baik kepada peserta didik. Tujuan dari penelitian ini adalah untuk mengetahui dan menjelaskan wawasan moderasi beragama dalam pengembangan desain pembelajaran Pendidikan Agama Islam. Penelitian ini menggunakan pendekatan kualitatif deskriptif dengan menggunakan metode studi litetarur. Penulis berperan sebagai instrumen utama dalam perencanaan, pengumpulan data, hingga interpretasi data. Berdasarkan pada sumber-sumber data dari berbagai literasi terkait, didapati bahwa pemahaman dan internalisasi moderasi beragama menjadi penting bagi peserta didik untuk menumbuhkan komitmen kebangsaan, toleransi, anti radikalisme dan kekerasan, serta sikap akomodatif terhadap kearifan lokal. Pembelajaran Pendidikan Agama Islam yang didesain secara kreatif dan komprehensif dapat meningkatkan keberhasilan pembelajaran, sehingga wawasan moderasi beragama dapat dipahami dan diinternalisasi dengan baik kepada peserta didik.
Paradigma Azyumardi Azra Tentang Pendidikan Islam Multikultural dan Implikasinya di Era Pandemi COVID -19
Authors: Shaleh Munif , Mahmudi Mahmudi
Published: January 2023

Penelitian ini menelaah tentang pemikiran Azyumardi Azra tentang pendidikan Islam multicultural. Penelitian ini termasuk dalam penelitian kualitatif. Data diperoleh dari hasil telaah kepustakaan.  Diskursus pendidikan multicultural memang sudah banyak dibahas, akan tetapi tataran praksisnya masih dapat dihitung jari. Pandangan Azra tentang pendidikan Islam multicultural selalu bergandengan dengan tujuan agama Islam. Dasar dari pendidikan Islam multicultural secara religious merupakan fitrah manusia yang diciptakan berbeda-beda. Dari segi falsafah kebangsaan, pendidikan Islam multicultural hadir dari semboyan Bhineka Tunggal Ika. Hasil dari pendidikan Islam multicultural adalah kepribadian peserta didik yang tidak hanya bertakwa, beriman, bermoral, tapi juga mempunyai sikap menghargai perbedaan dan berpengetahuan moderat.
Selected aspects of ensuring accessibility of historical buildings for people with mobility impairments
Authors: Rymsza Barbara , Kaperczak Krzysztof
Published: January 2023

The paper is devoted to the problem of providing people with mobility impairments, in wheelchairs, with crutches and the elderly, with access to monumental buildings located in the historic public space.

The authors present current technical and construction regulations concerning passageway infrastructure and the needs that result from limitations in people with mobility impairments.

Proposals for solutions to improve accessibility were also presented in a graphic form, making it easier to understand the intent of the proposed solution and showing examples of already applied solutions.

The paper addresses the problem of adaptation of sidewalks, parking spaces and entrances to buildings to the needs of such people while maintaining the recommendations on issues arising from the protection of cultural heritage, conservation recommendations and the historical nature of the space around monuments.

The authors of this paper have been working for years on the subject of accessibility of public space for people with disabilities, based on their own experience as a wheelchair user.

This article should serve as a prompt for historic site administrators on how, with minimal intervention, accessibility to historic sites can be improved and how to enable people with special needs to enjoy cultural assets.
Inclusive approaches in historic green spaces
Authors: Sikora Dorota
Published: January 2023

Abstract

         Zgodnie z ideami zrównoważonego rozwoju zawartymi w rezolucji ONZ "Przekształcamy świat: Agenda 2030 na rzecz zrównoważonego rozwoju" do kluczowych celów, jakich osiągnięcie założono do 2030 r., należą między innymi: zapewnienie powszechnego dostępu do bezpiecznych dla wszystkich i inkluzywnych terenów zieleni oraz przestrzeni publicznych, a jednocześnie wzmocnienie wysiłków na rzecz ochrony dziedzictwa kulturowego i przyrodniczego. W artykule przedstawiono, na wybranych przykładach zabytkowych parków, ogrodów oraz krajobrazów, jak cele te są realizowane. Przedmiotem badań były w szczególności: Ogród Wersalski, Stonehenge i krajobraz kulturowy otaczający ten zabytek, zarządzany przez English Heritage, a także polityka udostępniania zabytkowych, parków, ogrodów i krajobrazów, realizowana przez Historic England.

         Analiza strategii udostępniania zabytkowych terenów zieleni i krajobrazów kulturowych osobom ze szczególnymi potrzebami, wypracowanych przez wymienione powyżej instytucje, pozwoliła na sformułowanie w podsumowaniu artykułu propozycji ogólnych założeń inkluzywnej polityki względem tej grupy zabytków.
Ogrody zabytkowe – czy dla wszystkich?
Authors: Stachańczyk Renata
Published: January 2023

Wśród wielu kategorii zabytków dostępność ogrodów zabytkowych stanowi zagadnienie nadal słabo rozpoznane. Wymagania ustawowe koncentrują się na dostępności budynków i nie nakładają obowiązku dbania o przestrzeń otaczającą. Pomijają więc teren otaczający budynek, który jest najczęściej jego niezbędnym dopełnieniem i często podlega ochronie prawnej jako wpisane do rejestru zabytków otoczenie, ogród lub park, jako część zespołu czy zabytku obszarowego. Zapewnienie dostępności zabytków, w tym ogrodów zabytkowych jest zagadnieniem wspólnym dla budynku i jego zabytkowego otoczenia - obszernym i złożonym, które należy analizować kompleksowo, w kontekście całego obiektu zabytkowego.

W jego realizacji nie chodzi jednak o dopasowanie zabytku do wymogów dostępności - w rozumieniu przebudowy całości czy jego części, ale o wybór odpowiedniej opcji udostępniania – czyli zapewnienia takich rozwiązań, które nie wiążą się z nadmiernym obciążeniem, czy naruszeniem wartości ogrodu zabytkowego, w przeciwnym wypadku byłoby to sprzeczne z zasadami ochrony konserwatorskiej tych obiektów. Udostępnienie obiektu poprzez rozwiązanie kwestii dostępności architektonicznej może być skutecznie wspierane przez działania w sferze komunikacyjno-informacyjnej, które wydają się znacznie bezpieczniejsze w kontekście negatywnego wpływu na wartości zabytkowe obiektu niż likwidacja barier architektonicznych. Podstawowym warunkiem, który musi być przy tym spełniony jest przekazanie różnym grupom zainteresowanych uczciwej i wyczerpującej informacji o przygotowanej ofercie i o ewentualnych ograniczeniach dostępności. Ze względu na charakter zabytków obszarowych należy się spodziewać, że rzadko kiedy zarządzający ogrodem, będzie w stanie udostępnić go w pełni.
LITHME 2. (Language in the Human-Machine Era)
Authors: Benedek Enikő
Published: January 2023

Az Európai Tudományos és Technológiai Együttműködés (European Cooperation in Science and Technology, COST) kormányközi szervezet egyik célja, hogy a nyelvészeti és technológiai kutatásokat összefogja, és a két terület szakértőinek bevonásával felkészítse a tudományos közösséget az új technológiai fejlesztésekre.
Effect of Foot Reflection Massage on Blood Pressure Reduction in Hypertension Patients
Authors: Suryaningsih Sri , Tasalim Rian , Rahman Subhannur
Published: January 2023

Hypertension is a chronic condition caused by an increase in blood pressure above normal limits. Many non-pharmacological treatments have been found to lower blood pressure, such as foot reflexology, which has a relaxing effect to improve blood circulation. Objective: To analyze the effect of foot reflexology on reducing blood pressure in hypertensive patients. Methods: foot reflexology is given which has 3 stages of administration where each treatment is given for 15-20 minutes. This research is a pre-experimental research with an approach using the One Group Pretest Posttest Design. The population in this study were hypertension sufferers in the village of Paku Alam RT 02. In taking the sample the researchers used the purposive sampling technique with a total of 15 respondents and performed foot reflexology massage. The analysis used Paired t-test. Results: the results showed that blood pressure decreased after giving foot reflexology. After processing, based on the paired t-test, p value <0.005 (0.00<0.05) was obtained, so H0 was rejected and Ha was accepted. Conclusion: The Effect of Foot Reflexology Massage on Blood Pressure Reduction in Hypertension Patients in Paku Alam Village.
CLINICAL AND DIAGNOSTIC PROFILE OF MYOPATHY IN A TERTIARY CARE CENTRE
Authors: Prasad K Vinuthna , Ramu S , Murugan P K
Published: January 2023

Myopathies are a diverse group of disorders that primarily affect the structure, metabolism, or channel function of
skeletal muscles. They typically exhibit muscular weakness that interferes with daily activities. Motor dysfunction
without any sensory complaints is a common feature of myopathies.
Показатели качества и безопасности нетрадиционных видов муки для производства безглютеновых макаронных изделий
Authors: Абуова Алтынай Бурхатовна , Муслимов Нуржан Жумартович , Кабылда Анар Идашкызы
Published: January 2023

Введение. По данным ВОЗ, ежегодно до 30% населения промышленно развитых стран страдает болезнями пищевого происхождения. Научной основой современной стратегии производства безглютеновых продуктов питания служит изыскание новых ресурсов, обеспечивающих  оптимальное для организма больных целиакией соотношение питательных элементов, в то же время безопасных  пищевых продуктов. Цель. Изучить показатели качества и безопасности нетрадиционных видов муки из казахстанского сырья для производства безглютеновых макаронных изделий.Материалы и методы. Объектами представленных исследований служили рисовая, гречневая, кукурузная, нутовая виды муки, полученные из казахстанского сырья: риса (Кызылординская область), гречихи (Павлодарская область), кукурузы (из Алматинской области) и нута.  На первом этапе исследований определили физико-химических показатели качества и микробиологические показатели безопасности безглютеновых видов сырья для производства безглютеновых макаронных изделий российских и казахстанских производителей. На втором этапе исследований получены экспериментальные образцы безглютеновых макаронных изделий с использованием гречневой, кукурузной и рисовой муки и определены физико-химические и микробиологические показатели полученных новых безглютеновых макаронных изделий.Результаты. В Казахстане есть возможность возделывания сельскохозяйственных. культур, не содержащих глютен. В Республике Казахстан рис возделываются в Кызылординской, Туркестанской и Алматинской областях и на 2020 год засеяно 230 тысяч гектаров, при средней урожайности 61,8 ц/га  валовый сбор составил 551 тыс тонн, при внутреннем спросе 133 тыс. тонн. Из Казахстана 35-38 процентов из 551 тыс тонн риса экспортируется в качестве сырья. Выводы. По результатам проведенных исследований разработан технология безглютеновой муки и макаронных изделий с использованием сырья Республики Казахстан из смеси гречневой муки и кукурузной муки, а также смеси кукурузной и рисовой муки, которые по физико-химическим, микробиологическим и показателям безопасности соответствуют действующим нормативным документам и имеют хороший товарный вид. Результаты исследований имеют мультипликативный эффект: спрос на безглютеновые виды муки приведет к диверсификации растениеводства и к увеличению посевных площадей риса кукурузы, проса, масличных и бобовых культур и возрождению новых перерабатывающих предприятий различной мощности.
Еffect of the essential oil of Satureja montana L. on the growth of cultures of conditionally pathogenic microorganisms
Authors: Postnikova Olga N. , Shevkoplyas Ludmila A. , Kuevda Tatyana A. , Sataieva Tatiana P. , Kirsanova Marina A. , Logadyr Tatyana A.
Published: January 2023

Introduction. Essential oils contain antimicrobial components that are highly active against a wide range of microorganisms. Essential oils are natural, environmentally safe, low-toxic substances with a minimal list of side effects; no antimicrobial resistance is formed to them.
The aim of the research was to study the influence of the essential oil of Satureja montana L., growing in the Crimea, on the growth of cultures of opportunistic microorganisms.
Materials and methods. The short-term effect of savory oil on the growth of referenсе strains of microorganisms was studied in accordance with the European Standard for determining the rate of inactivation of microorganisms by the test substance (1997). To study the long-term effect of savory oil on clinical isolates of Staphylococcus aureus, we used the method of dilutions in a liquid medium, followed by measurement of the optical density of growth of the suspension culture biomass. The effect of savory oil on the formation of biofilms by clinical isolates of S. aureus was also studied.
Results. Whole savory oil and its dilutions of 1 : 10 and 1 : 100 with short-term action (1060 min) completely suppressed the growth of referenсе strains of bacteria; growth of the referenсе strain Candida albicans CCM 885 was inhibited only by whole oil and a 1 : 10 dilution, while a 1 : 100 dilution had a bacteriostatic effect. Dilutions of essential oil 1 : 100 and 1 : 1000 had a pronounced antibacterial effect on the suspension culture of clinical isolates of S. aureus. Savory oil also inhibited biofilm formation by 11 isolates S. aureus.
Conclusion. The essential oil of Satureja montana L. exhibits a pronounced antimicrobial effect against referenсе strains of S. aureus ATCC 25923, Escherichia coli ATCC 25922 and fungi C. albicans CCM 885. The antibacterial effect of this essential oil on clinical isolates of S. aureus allows us to offer it as a component of combined preparations for the treatment of infections caused by antibiotic-resistant strains of staphylococcus.
Virulence determinants and genotypes of Helicobacter pylori clinical isolates
Authors: Svarval Alena V. , Starkova Daria A. , Ferman Raisa S.
Published: January 2023

Background. H. pylori is the principal causative agent of gastroduodenal disorders in humans. The development and severity of lesions in infected individuals depend on the virulence of H. pylori strains.
Aims: Detection of virulence determinants and comparative analysis of H. pylori genotypes in patients with chronic gastritis (CG) and duodenal ulcer (DU).
Materials and methods. The 53 H. pylori strains were isolated in St. Petersburg from patients with CG (n = 34) and DU (n = 19). The genetic determinants of virulence cagA, iceA, vacA and H. pylori genotypes in patients with CG and UC were determined using the standard PCR method.
Results. The cagA gene was found in 64.1% of H. pylori strains. The proportions of cagA+ isolates from patients with CG and DU was 55.8% (15/34) and 78.9% (15/19), respectively (p 0.05). The iceA1 allele of H. pylori was detected in 47.4% of patients with DU, the iceA2 in 47.1% of patients with CG (p 0.05). The vacAs1 allele was significantly dominant in patients with DU 94.7% versus 70.6% in CG (p 0.05). No significant difference in vacA m1 and m2 alleles was found in H. pylori from different groups of patients (p 0.05). All cagA+ strains were carriers of the vacA s1 allele. The vast majority of strains (10 out of 11) of the cagA/vacAs2 genotype were isolated from patients with CG.
Conclusion. The significant association between vacAs1, vacAs2 allelic variants, as well as vacA s1/m2, vacA s2/m2 genotypes of the pathogen and severity of clinical manifestations of H. pylori infection has been established in our study. The vacAs1 and vacA s1/m2 genotypes of the pathogen are associated with duodenal ulcer.
Pelatihan Reference Managemenet Software (RMS) Zotero dalam pengelolaan Sumber Rujukan Penelitian
Authors: Asy’ari Muhammad , Hunaepi Hunaepi , Mirawati Baiq , Armansyah Armansyah , Rahmawati Helmi
Published: January 2023

Kurangnya pemahaman dan keterampilan mahasiswa dalam menggunakan Reference Managemenet Software (RMS) Zotero menjadi kendala dalam menyusun sumber pustaka yang sistematis dan presisi. Pengabdian Kemitraan Masyrakat ini bertujuan untuk meningkatkan pemahaman dna keterampilan mahasiswa pendidikan biologi menggunakan Reference Managemenet Software (RMS) Zotero dalam pengelolaan sumber rujukan. Mitra dalam kegiatan ini adalah mahasiswa semester enam program studi pendidikan biologi Universtas Pendidikan Mandalika, jumlah mitra yang terlibat 6 orang mahasiswa. Metode pelaksanaan adalah knowledge transfer dan Model Community development  dengan tahapan kegiatan; 1) plan, 2) implementation, dan 3) evaluation. Setelah kegitan dilaksanakan terdapat peningkatan pemahaman dan keterampilan mitra dalam memanfaatkan  Reference Managemenet Software (RMS) Zotero dalam pengelolaan sumber rujukan. Keterampilan menggunakan RMS Zotero penting untuk dimiliki oleh mahasiswa yang sedang menempuh matakuliah tugas akhir, sehingga materi tetang RMS Zotero ini perlu menjadi salah satu  pokok bahasan dalam mata kuliah teknik penulisan artikel ilmiah.
Zotero Reference Management Software (RMS) training in managing Research Reference Sources for Biology Education Students
The lack of students' understanding and skills in using Zotero's Reference Management Software (RMS) becomes an obstacle to compiling systematic and precise library sources. This Community Partnership Service aims to improve the understanding and skills of biology education students using Zotero's Reference Management Software (RMS) in managing referral sources. Partners in this activity are sixth-semester students of the Biology education study program at the Mandalika Education University, the number of partners involved is 6 students. The implementation method is a knowledge transfer and Community development model with activity stages; 1) plan, 2) implementation, and 3) evaluation. After the activity was carried out there was an increase in partners' understanding and skills in utilizing Zotero's Reference Management Software (RMS) in managing referral sources. The skill of using RMS Zotero is important for students who are taking final project courses, so this material about RMS Zotero needs to be one of the topics in the technical article writing engineering course.
Pendampingan Pascapanen Kopi Menggunakan Fermentasi Carbonic Maceration pada Mitra Piro Coffea Kabupaten Sukabumi
Authors: Ramdhan Billyardi , Ratnasari Jujun
Published: January 2023

Pengolahan kopi masyarakat di Piro Coffea umumnya masih menggunakan teknologi tradisional yang berpengaruh terhadap kualitas rasa, sehingga berdampak pada nilai ekonomi produk kopi tersebut. Pelaksanaan pengabdian ini bertujuan untuk meningkatkan teknologi pengolahan kopi sehingga dapat menghasilkan produk berkualitas. Kopi merupakan salah satu produk yang banyak dikonsumsi masyarakat. Pengolahan kopi masyarakat di Piro Coffea umumnya masih menggunakan teknologi tradisional yang berpengaruh terhadap kualitas rasa, sehingga berdampak pada nilai ekonomi produk kopi tersebut. Program Pengabdian ini berlangsung selama 5 bulan, melibatkan 2 orang dosen pelaksana, dan 3 orang mahasiswa sebagai pelaksana, serta mitra yang terdiri dari 5 orang dari pihak Piro Coffea. Pengabdian dimulai dari persiapan sampai evaluasi keberhasilan proses pendampingan yang dilakukan. Pengabdian ini dibagi menjadi 3 tahap, antara lain tahap observasi awal, implementasi program dan tahap evaluasi efektifivitas program. Akhir program menunjukkan adanya peningkatan kualitas kopi yang dihasilkan, kopi yang dihasilanya memiliki nilai kualitas 91% yang diukur dari rasa, aroma dan warna. Hal ini sesuai juga dengan capaian indikator kegiatan pelatihan yang menunjukkan adanya peningkatan pemahaman dan teknik pengolahan pasca panen kopi pada mitra Piro Coffea.
Post-harvest assistance for coffee using carbonic maceration fermentation at Mitra Piro Coffea, Sukabumi Regency
The coffee processing community at Piro Coffea generally still uses traditional technology which affects the quality of taste, so it has an impact on the economic value of the coffee product. The implementation of this service aims to improve coffee processing technology so that it can produce quality products. Coffee is one of the products that are consumed by many people. This Service Program lasted for 5 months, involving 2 implementing lecturers, and 3 students as implementers, as well as partners consisting of 5 people from Piro Coffea. Service begins from preparation to the evaluation of the success of the mentoring process carried out. This service is divided into 3 stages, including the initial observation stage, program implementation, and program effectiveness evaluation stage. The end of the program shows an increase in the quality of the coffee produced, the coffee it produces has a quality value of 91% as measured by taste, aroma, and color. This is also consistent with the achievement of indicators for training activities which show an increase in understanding and techniques of post-harvest coffee processing among Piro Coffea partners
Peningkatan Kesejahteraan Masyarakat Melalui Pengelolaan Dana Desa Di Desa Molas Kecamatan Bongomeme Kabupaten Gorontalo
Authors: Nggilu Rukiah , Katili Andi Yusuf , Rachman Ellys , Gobel Lisda Van
Published: January 2023

Kesejahteraan masyarakat merupakan salah satu yang harus menjadi perhatian pemerintah karena hal demikian telah menjadi tanggung jawabnya, agar tidak ada rakyat Indonesia yang miskin dalam kehidupan berbangsa dan bernegara. Tujuan pengabdian kepada masyarakat ini adalah untuk memberikan penyuluhan kepada pemerintah Desa Molas, agar mampu lebih memahami bagaimana memanfaatkan dana desa dengan sebaik-baiknya untuk menyejahterakan masyarakatnya. Metode yang digunakan dalam proses pengabdian kepada masyarakat ini adalah penyuluhan tentang penggunaan dana desa secara efektif dan efisien agar tujuan dalam meningkatkan kesejahteraan masyarakat tercapai. Lokasi pengabdian dilakukan di Desa Molas, Kecamatan Bongomeme, Kabupaten Gorontalo, yakni pada 31 Mei hingga 1 Juni 2022. Hasil kegiatan yang dilakukan dalam proses pengabdian kepada masyarakat adalah aparat desa dapat lebih paham cara pengelolaan dana desa sesuai peruntukkannya, hal ini sebagaimana tertuang dalam undang-undang, dimana tujuannya antara lain adalah untuk kesejahteraan masyarakat.
Improving Community Welfare Through Village Fund Management in Molas Village, Bongomeme District, Gorontalo Regency
Community welfare is one that the government should pay attention to because it has become its responsibility, so that no Indonesian people are poor in the life of the nation and state. The purpose of this community service is to provide counseling to the government of Molas Village, so that they are able to better understand how to make the best use of village funds for the welfare of their people. The method used in the community service process is counseling on the effective and efficient use of village funds so that the goal of improving community welfare is achieved. The location of the service is carried out in Molas Village, Bongomeme District, Gorontalo Regency, namely from 31 May to 1 June 2022. The results of the activities carried out in the community service process are that village officials can better understand how to manage village funds according to their designation, this is as stated in the law -law, where the goal is among others for the welfare of the community.