bluuebunny/crossref_metadata_2025 huggingface dataset:
Revegetasi Lahan Miring dengan Pola Agroforestri Tanaman Unggulan Lokal untuk Mengurangi Erosi Tanah dan Peningkatan Ekonomi Masyarakat di Desa Arga Indah I, Bengkulu Tengah
Authors: Senoaji Gunggung , Hidayat M. Fajrin , Anwar Guswarni , Lukman Agung Hasan , Susanti Elvi
Published: October 2022

Kondisi lahan pertanian di Desa Arga Indah I, Kec. Pagar Jati, Bengkulu Tengah didominasi oleh topografi miring. Hal ini memerlukan pengelolaan lahan yang tepat agar mampu memberikan produksi pertanian yang berkelanjutan. Oleh karena itu, pemeliharaan kualitas tanah melalui pencegahan erosi untuk mempertahankan produktivitas lahan penting dilakukan. Kegiatan ini memperkenalkan teknik pengelolaan lahan dengan melakukan revegetasi lahan miring melalui pola panam agroforestri dengan tanaman unggulan lokal (Durian Bentara dan pala).  Tujuan dari kegiatan ini adalah agar masyarakat mengetahui teknik pengolahan lahan miring yang dapat memberikan keuntungan ekonomi dan sekaligus mengurangi erosi tanah. Metode yang digunakan adalah survei, penyuluhan, dan demonstrasi. Penyuluhan dilakukan secara komprehensif sebagai upaya persiapan untuk pembuatan demplot. Demonstrasi dilakukan sebagai praktik pembuatan demplot. Hasil kegiatan menunjukkan bahwa masyarakat menjadi tahu dan menambah wawasan tentang teknik pengelolaan lahan miring dengan menanam tanaman unggulan lokal pada lahan pertaniannya melalui sistem agroforestri. Masyarakat desa juga mulai mengetahui bahwa Durian Bentara merupakan tanaman unggulan lokal yang dapat dibudidayakan sebagai salah satu sumber pendapatan masyarakat dan berperan juga sebagai sarana perlindungan lingkungan tanah.
Pembuatan Obat Sediaan Selama Pendemi COVID-19 Bagi Keluarga SMA Negeri 8 Kota Bengkulu Sebagai Bantuan S2 Kimia Universitas Bengkulu
Authors: Putranto Agus M.H , Widiyati Eni , Gustian Irfan , Sutanto Teja Dwi
Published: October 2022

Pengabdian Pada Masyarakat dari Dana Bantuan Pengabdian S2 Kimia tahun 2020 berjudul “Pembuatan Sediaan Obat Sederhana Bagi Keluarga Besar SMA Negeri 8 Kota Bengkulu” telah dilaksanakan pada tanggal 8 Desember 2020. Metode yang dipergunakan pada pengabdian ini meliputi ceramah, diskusi dan praktik pembuatan obat sederhana, meliputi pembuatan sediaan obat herbal untuk pengobatan Covid-19 dari daun muda tanaman sungkai. Setelah dilakukan pengabdian berupa pelatihan pembuatan obat sederhana dan dari hasil evaluasi dapat disarikan bahwa, para guru, tenaga ke pendidikan dan siswa SMA.N 8 Bengkulu, sangat antusias selama pelatihan pengabdian, dibuktikan dengan banyak nya pertanyaan yang muncul saat pelatihan, dari peserta pengabdian ini. Dari hasil evaluasi pelaksanaan pengabdian ini diketahui bahwa pengabdian ini sangat menarik dan bermanfaat bagi keluarga besar SMA Negeri 8 Kota Bengkulu. Setelah selesai pengabdian ini para peserta menjadi tahu cara pembuatan sediaan obat sederhana yang sangat bermanfaat bagi keluarga besar SMA.N 8 Kota Bengkulu.  Kata kunci: Sediaan obat; Herbal; Covid-19
Pemberdayaan Masyarakat Desa Tapak Gedung Melalui Pengolahan Kulit Buah Kopi Menjadi Teh Kaskara
Authors: Apriansyah1 Dony , Osira 2 Yessilia , Rozzaqiah Anisa , Wahyuningrum Yuanda , Afifah Aras Adzro
Published: October 2022

Desa Tapak Gedung Kecamatan Tebat Karai Kabupaten Kepahiang, Provinsi Bengkulu memiliki 1600 ha perkebunan buah kopi yang mampu menghasilkan 700 ton kopi dalam setahun. Selama ini, kopi tersebut hanya dijual dalam bentuk biji kopi, bahkan kulit kopipun hanya dibuang saja dan belum dimanfaatkan untuk kesejahteraan masyarakat karena keterbatasan pengetahuan dan keterampilan serta sarana pengolahannya. Berdasarkan latar belakang tersebut, maka Universitas Bengkulu melalui Program PHP2D melakukan serangkaian kegiatan pemberdayaan masayarakat Desa Tapak Gedung melalui pengolahan limbah kulit buah kopi menjadi teh kaskara. Pemberdayaan masyarakat ini dilakukan melalui kegiatan sosialisasi teh kaskara, pelatihan masyarakat tentang pembuatan teh kaskara, pengkemasan dan pengenalan pemasaran produk teh kaskara. Hasil kegiatan pemberdayaan ini menunjukkan bahwa: 1) Limbah kulit buah kopi di Desa Tapak Gedung bisa diolah menjadi teh kaskara yang nikmat dan bermanfaat bagi kesehatan tubuh. 2) Antuasisme masyarakat Tapak Gedung, terutama generasi muda merupakan potensi yang bisa dioptimalkan dalam pengolahan teh kasakara. 3) Perlunya dukungan pemerintahan, akademisi dan sektor swasta untuk pengembangan produk teh kaskara sehingga menjadi produk yang mempunyai nilai tambah bagi kesejahteraan masyarakat
Requirements decision-making as a process of Argumentation: A Google Maps Case Study with Goal Model
Authors: Khan Javed Ali , Yasin Affan , Assam Muhammad , Khan Wasiat , Shah Syed Yaqub , Khan Rehan Ali
Published: October 2022

In social media platforms, crowd-users extensively interact and contribute information related to software applications. Usually, crowd-users discuss software features or hot issues and record their opinions about the software applications under discussion either in textual form or via end-user votes. Such requirements-related information is considered a pivotal alternative source for requirements engineers to the already existing in-house stakeholders in order to illustrate decision-making. Also, requirements decision-making for Crowd requirements engineering is a difficult task, as it is always based on incomplete knowledge and requires trade-offs from multi-perspectives. However, existing requirements models and associated tools are still lacking, which enable requirements engineers to make informed decision-making and capture conflicting requirements knowledge. This paper elaborates the interaction among the crowd-users about the Google Map mobile application in the Reddit forum to recover conflicting requirements-related information using the goal modeling approach. For this purpose, we extracted critical arguments from a crowd-users conversation in user forums regarding a given design; built a graphical argumentation model based on the extracted information; aligned types of arguments with goal-oriented modeling constructs in the non-functional requirements framework; conducted exiting goal-model analysis to the requirements model to reach consensus based on argumentation and reasoning, such as supporting, attacking, undefined, and conflicting. The proposal is described with illustrative example models and the associated evaluation processes of design decision-making situation for Google Map interface design.
Detecting Aphid Concentration in Wheat Leaf Using Remote Sensing and GIS
Authors: Khan Rao Mansor Ali , Batool Saira , Rana Qamar Shabbir , Mahmood Syed Amer , Rasheed Mamoon ur
Published: October 2022

Wheat lies among the most prominent cereal crop of Pakistan which has a significant role in the stability of Pakistan’s economy. Certain biotic and a biotic factors including agro-climatic conditions, rainfall, lack of irrigation infrastructure and conventional agricultural methods are raising the risk of aphid attacks. The current study utilized satellite imagery for obtaining thermal datasets of complete wheat growth. Results revealed that rainfall is a significant parameter for the determination of aphid growth on wheat plant. A region receiving 0-10 mm rainfall, supported the growth of aphid. Moreover, the aphid survival was highly supported at a moderate temperature ranging between 20-25 oC with relative humidity ranging from 70-75 %. The study also revealed the production of weed in wheat crop acted as a moistrizing agent which consequently provided favorable conditions to the aphid population for growth. Inapropriate usage of fertilizers increased the nitrogen content in soil which turned to be favourable for the aphid attack. Thus, the study concludes that agro-climatic conditions must be considered before the application of pesticides.
Psychosocial Factors as the Determinants of Relapse in Individuals with Substance Use Disorder
Authors: Farooq Najwa , Riaz Dr. Saima
Published: October 2022

Relapse to substance abuse after withdrawal is one of the most perplexing and frustrating aspect of addiction. The word relapse defines as collapse/hindrance to the client’s prior substance dependence behavior after treatment due to many psychological, social, and other associated factors. This study is designed to find out the psychological and social factors which determine relapse behavior in individuals with substance use disorder. A cross-sectional study was conducted among 200 relapse patients from November 2020 to January 2021 in different rehabilitations in Wazirabad, Gujranwala, Lahore, Gujrat, and Sialkot cities of Pakistan. Data were collected by using a psychosocial functioning scale. Data analyzed using SPSS 21. A total of 200 individuals were taken ,of which 170 were males and 30 females. The results indicates that the most important predictor was risk-taking 0.148 (100% of normalized importance) followed by social conformity 0.130 (88% of normalized importance), decision making confidence 0.128 (86.2% of normalized importance), childhood problem 0.125 (84.4% of normalized importance), hostility 0.125 (84.0% of normalized importance), depression 0.119 (80.5% of normalized importance), self-esteem 0.114 (76.6% of normalized importance) and anxiety 0.111 (74.7% of normalized importance).Social factors were connected with a high relapse rate. These results may help clinicians to improve treatment and policy guidelines for the prevention of relapse to drug addiction.
SISTEM INFORMASI PENJUALAN PETI MATI BERBASIS WEB DI CV. GEOJAYA NUSANTARA
Authors: Nababan Joko Priono , Dari Wulan
Published: October 2022

Abstract—Sales is an activity that connects customers with sellers through a product or service offered to produce something that is mutually beneficial for both parties. So for that we need a system so that sales transactions can run effectively and efficiently, for example by using a sales information system. CV. Geojaya Nusantara is a company engaged in the sale of coffins. The existing sales system in CV. Currently, Geojaya Nusantara is still carried out conventionally, such as customers who want to buy their products via phone calls or also through messaging applications such as the WhatsApp application. Then the incoming sales data is still done manually, as recorded in a sales book. Therefore, with these problems, a web-based application is needed to support the sales system which aims to simplify all transaction processes, because it can be done anytime and anywhere. The research method used is by conducting direct observations and interviews with employees or shop owners. As for the software development method used is the waterfall method and the programming language used in making the website itself is PHP, HTML, CSS, and JQuery, and for the database it uses MySQL. The expected results in this web-based coffin sales information system at CV Geojaya Nusantara, are expected to be a solution to overcome the problems encountered due to the conventional system, and can also overcome errors in the sales recording input process.

 

Keywords: coffin sales, information system, web-based
Effect of Chloroquine Wash-out Period of Photosensitizers in the Skin and Selected Organs in Rats.
Authors: Zima T , Jirsa M , Jirsa M , Jirásková M , Bradová V , Stádník B
Published: October 2022

In the last decade, photodynamic therapy has become an alternative method for the diagnosis and therapy of tumors. In human medicine hematoporphyrin derivatives, sulfonated hydrophilic meso-tetraphenylporphyrin (TPPS4) and an oligomer of hematoporphyrin (Photosan 3), are widely used. Chloroquine is used for the treatment of porphyria cutanea tarda for its power to release porphyrins from the liver tissue. The kinetics of two porphyrin photosensitizers TPPS4 and Photosan 3 in the skin and some organs as well as the effect of chloroquine on the porphyrin excretion and their accumulation in skin and organs of Wistar rats were studied. TPPS4 exhibited maximum fluorescence in skin 48 h after application with decreasing to basal level from the 8th to the 14th day. Maximum fluorescence was reached at 72 hours after Photosan 3 application and it decreased to basal level during 96 hours after application. TPPS4 caused significantly higher fluorescence compared to Photosan 3. Chloroquine after oral administration did not change the fluorescence of skin, but it significantly decreased the TPPS4 concentration in rat organs if chloroquine treatment started 3 days or 2 weeks after TPPS4 application. Chloroquine significantly decreased the serum TPPS4 concentration during the period of 28 days. Fluorescence of skin was significantly higher and lasted longer after application of TPPS4 compared to Photosan 3. Chloroquine after oral administration did not influence the fluorescence of the skin, but it significantly decreased the TPPS4 concentration in rat organs. This effect could be useful in photodynamic therapy for mobilizing exogenous porphyrins from tissues after parenteral photodynamic therapy.
A Giant Retrorectal Epidermoid Cyst Successfully Treated with Laparoscopic Excision: A Case Report and Literature Review
Authors: Chow Hin San , Chan Justin C Y , Cheung Wai Hung , Lai Tak Wing
Published: October 2022

Abstract A retrorectal epidermoid cyst is an uncommon lesion. It is believed to be a congenital lesion arising from the remnants of the embryonic tissues. Such lesion causes vague symptoms and thus poses challenge in diagnosis. Laparoscopic excision was advocated in selected cases, which enables a deep access to and excellent visibility of retrorectal region. We report a rare case of a giant retrorectal epidermoid cyst in a 22-year-old lady who complained of dysmenorrhea. Laparoscopic excision was successfully performed. The diagnosis of retrorectal epidermoid cyst was confirmed upon histological examination of the surgical specimen. Follow-up at 1 month and 7 months later showed no disease recurrence.
Eski Orta -Asya Türk Kamu Hukuku'nda Kağanların Nitelik ve Vasıfları
Authors: PAMİR Aybars
Published: October 2022

Kağan, eski Orta-Asya Türk Kamu Hukuku’nun temel sujesiydi. Egemenlik hakkını doğrudan kullanan kağanın çok önemli görev ve sorumlulukları bulunmaktaydı. Kağan bir yandan da bazı temel nitelik ve vasıflara sahip olmalıydı. Bütün bunlar güçlü bir devlet yapısının sağlanabilmesinin temel koşulları olarak çeşitli kaynaklarda sıralanmışlardır.
Ölüme Bağlı Tasarrufların Tahvili
Authors: KAŞAK Fahri Erdem
Published: October 2022

Kesin hükümsüz bir hukukî işlemin, benzer ekonomik sonuçlar doğuran bir başka işleme çevrilerek ayakta tutulmasına tahvil denir. Tahvil müessesesi, Alman hukukunun aksine genel bir hükümle düzenlenmemesine rağmen, Türk ve İsviçre hukukunda da kabul görmektedir. Bununla birlikte tahvilin hangi hukukî temele dayandığı hususunda farklı görüşler vardır. Unsurlarının mevcut olması hâlinde tahvil, re’sen gerçekleşir. Kural olarak her türlü hukukî işlemde söz konusu olabilmekle birlikte tahvil kurumu, sağlar arası hukukî işlemlerden ziyade ölüme bağlı tasarruflarda önem arz eder. Zira yaptıkları hukukî işlem geçersiz olan tarafların, sonradan aynı hukukî işlemi geçersizliğe yol açan sebepten arî olarak yapabilmeleri mümkündür. Oysaki ölüme bağlı tasarrufların geçerli olup olmadıkları miras bırakanın ölümüyle birlikte gündeme geldiği için geçersiz ölüme bağlı tasarrufun geçerli bir şekilde yapılabilmesi söz konusu olamaz. Nitekim bu sebeple kanun koyucu, miras hukukuna ilişkin bazı hükümlerde tahvilin gerçekleşeceğini açıkça düzenlemiştir. Anılan kanunî tahvil düzenlemelerine ek olarak tahvilin unsurlarının mevcut olduğu başka hâllerde de tahvil söz konusu olabilir.
Peculium Kurumunun Yapay Zekâya Sahip Robotların Hukukî Statülerinin Tespitinde Model Olarak Kullanılması
Authors: MINDIZ Emine
Published: October 2022

Kölelik kurumuna ilişkin olarak Roma hukuku tarafından getirilen düzenlemelerin, yapay zekâya sahip robotların hukukî statüsünün ve yapay zekâ kullanımından doğan hukukî sorumluluğun belirlenmesinde model olarak alınması ise, bu robotların kişi olarak kabul edilmelerinin özellikle hukukî sorumluluğun belirlenmesi bağlamında yaratabileceği olumsuz sonuçların ortadan kaldırılmasına imkân verecektir.
‘Çocuk Teslimi ve Çocukla Kişisel İlişki Kurulmasına İlişkin Mahkeme Kararlarının Yerine Getirilmesi: Karşılaştırmalı Hukuk ve 7343 Sayılı Kanun'un Getirdiği Değişiklikler Çerçevesinde Değerlendirmeler'
Authors: BÖRÜ Levent , PARLAK BÖRÜ Şafak
Published: October 2022

Çocuk teslimi ve çocukla kişisel ilişki kurulmasına dair mahkeme kararlarının yerine getirilmesi, Türk yasa koyucusunun getirmiş olduğu yeni değişiklikler nedeniyle oldukça güncel bir konudur. Çocuk teslimi ve çocukla kişisel ilişki kurulmasına ilişkin mahkeme kararlarının yerine getirilmesine ilişkin sistem 7343 sayılı Kanunla değişmiştir. İcra İflas Kanunu hükümleri çerçevesindeki, uzun zamandır yoğun eleştirilere uğrayan uygulama sona ermiş; Çocuk Koruma Kanunu’na ve Türk Medeni Kanunu’na eklenen yeni hükümler uyarınca çocuğun üstün yararını daha iyi gözetmesi hedeflenen yeni bir sistem geliştirilmiştir. Çalışmamızda mevzuat değişikliğine duyulan ihtiyacın gerekçesi ve yeni sistemin ortaya çıkış süreci ele alınmıştır. Türk hukukunda geliştirilen sisteme ışık tutması amacıyla, yabancı hukuklarda konunun yasal düzenlemeler ve uygulama bağlamında nasıl ele alındığına; ülkeden ülkeye çeşitlilik arz etmekle birlikte, öngörülen tedbir ve yaptırım mekanizmalarına yer verilmiştir. Son olarak 7343 sayılı Kanunun getirdiği değişiklikler ele alınmıştır. Yeni sistemin genel itibarıyla olumlu yönleri olmakla birlikte, sistemin çocuğun üstün yararının korunmasında ne derece etkin olabileceğinin ancak gelişen uygulamayla sağlıklı değerlendirilebileceği düşünülmektedir.
Arsa Payı Karşılığı İnşaat Sözleşmesinin Tüketici İşlemi Sayılıp Sayılamayacağı Sorunu
Authors: YILDIRIM Abdulkerim
Published: October 2022

Bir tarafını arsa sahibinin diğer tarafını ise yüklenicinin oluşturduğu arsa payı karşılığı inşaat sözleşmelerini Yargıtay tüketici işlemi olarak kabul etmemekte ve bu sözleşmelerden doğan uyuşmazlıkların tüketici mahkemesinin görev alanına girmediğine karar vermektedir. Yüksek Mahkeme’ye göre; arsa payı karşılığı inşaat sözleşmelerinde arsa sahibi tarafından güdülen gaye, kullanmak için konut edinmek değil arsasını değerlendirmektir. Peşin bir kabulle bu tür sözleşmeleri tüketici işlemi dışında görmek 6502 sayılı Tüketicinin Korunması Hakkında Kanun (TKHK)’daki tüketici işlemi tanımına uygun değildir. Her somut olayda durumun hâkim tarafından incelenmesi gerekir. Arsa payı karşılığı inşaat sözleşmesinde yüklenicinin, ticari veya mesleki amaçlarla hareket ettiğinde kuşku yoktur. Sözleşmenin karşı tarafını oluşturan iş sahibi, somut olayda, arsanın devri karşılığında kendisinin veya yakınlarının kullanımı için konut veya tatil amaçlı taşınmaz edinmek amacıyla sözleşmeye taraf olmuşsa (yani ticari veya mesleki olmayan amaçlarla hareket etmişse) tüketici işleminden bahsetmek mümkün olur. Bu noktada, yükleniciye bedelini ödeyerek kullanmak amacıyla konut veya tatil amaçlı taşınmaz mal edinen biri ile arsasını vererek yine kullanmak amacıyla konut veya tatil amaçlı taşınmaz edinmek isteyen biri arasında ayrım yapmak TKHK’nın amacına aykırıdır. Zira her iki durumda da yüklenici karşısındaki kişiler, eşit şekilde korunmaya layıktır.
Effects of Ornithine Aspartate and Empagliflozin on Memory Deficit Symptoms in Experimental Steatohepatitis
Authors: Prikhodko V. A.
Published: October 2022

In this study, L-ornithine L-aspartate and empagliflozin were evaluated in terms of their potential effects on the hippocampus-dependent memory status in non-alcoholic steatohepatitis (NASH) in C57Bl/6 mice. NASH was found to be associated with an early transient decrease in the short-term recognition memory as well as a progressive reduction in the short-term spatial memory. L-ornithine L aspartate effectively prevented the impairment of recognition, rather than spatial, memory. At the same time, empagliflozin failed to improve the memory status of the animals.
Changes in the Gut Microbiota of Mice Under the Action of Ultrasonic-induced Stress
Authors: Karabanov S. Yu. , Kibitkina A. A.
Published: October 2022

The effect of ultrasound-induced stress on the gut microbiota composition of C57BL/6 mice was studied. Under the action of this type of stress, the gut microbiota composition shifts towards firmicutes at the phylum level. At the family level, an increase in Lachnospiraceae by 67.43%, Rikenellaceae by 39.29%, as well as a decrease in Bacteroidaceae by 64.75% and Prevotellaceae by 38.51%. is observed. The most prominent changes under the action of stress were revealed at the genus level: out of 28 identified genera, significant changes were recorded in 13.
In response to crisis: the use of songs to respond to multiple crises in Yusuf Islam (Cat Stevens)' post-conversion lyrical compositions
Authors: Tahir Azwar
Published: October 2022

Yusuf Islam, also known as Cat Stevens, is a well-known singer and songwriter. He had decided to avoid the music industry for many years. He focused more on humanitarian activism as well as building educational institutions in London. In 2006, through the release of the album entitled "An Other Cup", Stevens marked his return to popular music with a strong intention to carry his Islamic vision. Furthermore, he connected his humanitarian activism with his lyrical compositions. The artist has shown very intense participation in crises that happened across countries. In dealing with these crises, the use of a single seemed very rational since such crises need a fast response and a single song is easier to compose than an album. The result of those circumstances is Stevens' releasing several songs in response to multiple crises across different countries. He released "The Little Ones" to voice the misery of the genocide in Bosnia. Similarly, Islam released "Indian Ocean" for the victims of the tsunami in Indonesia, "My People" to support people's freedom regarding political turmoil in the Arab world, such as Egypt and Tunisia, and "He Was Alone" to show sympathy for children's refugees at the Syrian-Turkish border. These responses were all released in his post-conversion phase. This essay argues that Islam, also known as has used his post-conversion lyrics, particularly his singles, to help voice the misery of the victims of multiple crises.
KEEFEKTIFAN MODEL PEMBELAJARAN KOOPERATIF TIPE THINK TALK WRITE PADA MATERI BANGUN RUANG SISI DATAR DI MTS DARUL QUR’AN TAHUNAJARAN 2020/2021
Authors: Wardania Elina , Dwi Rahmawati Novia
Published: October 2022

Pembelajaran matematika yang dilakukan oleh guru dikelas masih menggunakan metode konvensional yang berfokus pada guru (teacher center) sehingga mengakibatkan proses pembelajaran yang monoton, siswa cenderung merasa bosan, kurang aktif, bahkan tidak menyukai materi yang diajarkan. Adapun hasil belajar siswa yang rendah dapat disebabkan oleh beberapa faktor yang salah satunya adalah peggunaan metode/model pembelajaran yang kurang tepat.Tujuan penelitian yang ingin dicapai dalam penelitian ini adalah untuk mendeskripsikan keefektifan model pembelajaran kooperatif type Think Talk Write (TTW) materi bangun ruang sisi datar yang ditinjau dari aktivitas siswa, hasil belajar siswa, dan respon siswa. Rancangan penelitian ini One-Shot Case Study dengan sampel penelitian kelas VIII-B yang berjumlah 28 siswa di Mts Darul Qur’an. Teknik pengumpulan data menggunakan metode observasi, tes, dan angket dengan instrumen berupa lembar pengamatan aktivitas siswa, lembar soal posttest, dan lembar angket respon siswa.Hasil penelitian ini menunjukkan bahwasanya penelitian menggunakan model pembelajaran kooperatif tipe Think Talk Write (TTW) efektif. Hal ini dikarenakan telah memenuhi syarat keefektifan, yakni : (1) Aktifitas siswa selama proses pembelajaran termasuk dalam kategori aktif, (2) Ketuntasan hasil belajar siswa secara klasikal ≥ 75%, (3) Respon siswa positif terhadap pembelajaran. Dengan demikian dapat disimpulkan model pembelajaran kooperatif tipe Think Talk Write (TTW) dikatakan efektif digunakan.
EKSPLORASI KEMBALI ETNOMATEMATIKA PADA JAJANAN PASAR DI DAERAH CILEUNGSI
Authors: Mulyatna Fauzi , Karim Abdul , Wiratomo Yogi
Published: October 2022

Pembelajaran mengenai konsep matematika sangatlah penting demi meningkatkan pemahaman siswa terhadap materi. Peran serta budaya dalam menumbuhkan karakter dan identitas bangsa, dapat seiring sejalan dengan integrasi budaya sebagai media dalam menumbuhkan pemahaman terhadap konsep matematika. Etnomatematika memudahkan kita memahami konsep matematika sekaligus mempelajari budaya yang ada di sekitar kita. Tujuan dari penelitian ini untuk mengetahui etnomatematika pada jajanan pasar dengan materi matematika geometri. Metode penelitiannya adalah kualitatif dengan pendekatan etnografi. Hasil penelitian yang didapat yaitu terdapat unsur budaya dan materi matematika geometri pada jajanan pasar yang ada di Daerah Cileungsi.
Investigation of the Cultural Competence Levels of Diabetes Nurses
Authors: ÇINAR Derya , OLGUN Nermin , KOYUNCU Aynur
Published: October 2022

Objective: It is important for nurses to have cultural competence in order to keep up with the cultural diversity brought by globalization. In this study, we aim to examine the cultural competence levels of diabetes nurses in diabetes education and care in accordance with the cultural characteristics of individuals with diabetes.

Methods: This study was conducted in a cross-sectional descriptive type with 183 diabetes nurses between September 15 and December 15, 2020 in Turkey. The data were collected using the Introductory Information Form and the Nurse Cultural Competence Scale.

Results: We determine that almost all of the diabetes nurses had cultural competence above the average. We find that having a postgraduate degree from diabetes nurses, receiving cultural education before, and having a diabetes nurse experience of 6 years or more affected the cultural competence levels (p
Synthesis of Nanoparticles Loading Indenopyrazole Derivatives and Evaluation of Biological Features
Authors: DOĞAN Murat , KOÇYİĞİT Ümit Muhammet , GEZEGEN Hayreddin
Published: October 2022

Objective: In this study, it was aimed to prepare nanoparticle formulations using chitosan, a cationic natural polymer, and tripoly phosphate, and to perform mechanical characterization and in vitro cell culture studies. In addition, the cytotoxic effects of nanoparticles containing indenopyrazol derivatives against human glioma cells (C6) and human cervical cancer cells (HeLa) were investigated.

Methods: Within the scope of the study, nanoparticles containing indenopyrazole derivative were prepared and characterization of particle size, zeta potential and morphological properties were performed. XTT cytotoxicity test was applied to evaluate the antiproliferative activities of nanoparticles containing these components.

Results: Particle size, zeta potential and morphological properties of nanoparticles were observed to be suitable for application. In vitro cell culture studies showed that nanoparticles containing indenopyrazol derivatives showed better cytotoxic effects in both cell lines.

Conclusion: The results showed that the mechanical properties of nanoparticles containing indenopyrazol derivatives are suitable and can be applied in anticancer activity studies.
USE OF E-BANKING IN ISLAMIC BANKS IN INDONESIA
Authors: Nurjannah Afifah Zahroh , Santoso Suryo Budi
Published: October 2022

This article focuses on the use of computer bases in making bank accounts at Islamic banks, and later on the data will be compared with existing data in conventional banks. This is because in banking, there are two types of banks based on their operational activities, namely Islamic banks and conventional banks. The research in this article is a qualitative study, because it requires various information from Islamic banks and conventional banks. From the information obtained related to Islamic banks and conventional banks, both types of banks have used E-Banking services to make it easier for their customers. However, there are some differences regarding the E-Banking services provided by each bank. So with the research in this article, it is expected to be able to provide information regarding the differences in E-Banking services that exist in Islamic banks and conventional banks. The results of this study are able to provide information related to what e-banking is used by conventional banks and Islamic banks.
ANALISA PENERAPAN DISASTER RECOVERY PLAN PADA DATA CENTER PERUSAHAAN
Authors: Makpul Zulkarnain Bin Muhammad
Published: October 2022

Disaster recovery plan atau DRP merupakan sebuah perencanaan yang digunakan unutk menjalankan operasional dalam kondisi terjadi gangguan. Saat ini perusahaan tidak mempunyai gambaran tentang keberhasilan implementasi DRP. Dengan melakukan analisa implementasi disaster recovery plan pada data center perusahaan,  maka peneliti akan mengetahui apakah implementasi DRP sudah dilakukan dengan benar, apabila terjadi bencana atau gangguan, perusahaan masih bisa menjalakan operasionalnya atau bisa juga mengembalikan system dengan waktu yang cepat. Penelitian ini menggunakan metode deskriptif kualitatif. Sumbar data diambil dari pengamatan langsung, melakukan pengecekan dokument serta melakukan wawancara. Hasil dari analisa dan pembahasan, penulis akan mengetahui tentang beberapa kegiatan atau proses DRP yang telah dilakukan dengan benar dan ada juga beberapa kegiatan atau proses yang harus menjadi fokus perbaikan.
Phenotypic characterization of regional human meniscus progenitor cells
Authors: Wang Jingsong , Roberts Sally , Li Weiping , Wright Karina
Published: October 2022

Stimulating meniscus regeneration using meniscal progenitor cells has been suggested as a promising new strategy. However, there is a lack of studies which decisively identify and characterize progenitor cell populations in human meniscus tissues. In this study, donor-matched progenitor cells were isolated via selective fibronectin adhesion from the avascular and vascular regions of the meniscus and chondroprogenitors from articular cartilage (n = 5). The mixed populations of cells from these regions were obtained by standard isolation techniques for comparison. The colony formation efficacy of avascular progenitors, vascular progenitors and chondroprogenitors was monitored using Cell-IQ® live cell imaging. Proliferation rates of progenitors were compared with their mixed population counterparts. Cell surface markers indicative of mesenchymal stromal cells profile and progenitor markers were characterized by flow cytometry in all populations. The fibrochondrogenic capacity was assessed via fibrochondrogenic differentiation and measuring GAG/DNA content and morphology. All meniscal progenitor and chondroprogenitor populations showed superior colony forming efficacy and faster proliferation rates compare to their mixed populations. Progenitor populations showed significantly higher positivity for CD49b and CD49c compared to their mixed population counterparts and chondroprogenitors had a higher positivity level of CD166 compared to mixed chondrocytes. GAG/DNA analysis demonstrated that progenitor cells generally produced more GAG than mixed populations. Our study demonstrates that the human meniscus contains meniscal progenitor populations in both the avascular and vascular regions. Meniscal progenitors derived from the vascular region exhibit enhanced proliferative and fibrochondrogenic characteristics compared to those from the avascular region; this may associate with the enhanced meniscal healing potential in the vascular region. These findings build on the body of evidence which suggests that meniscal progenitors represent an attractive cell therapy strategy for meniscal regeneration.
New frontiers of oral sciences: Focus on the source and biomedical application of extracellular vesicles
Authors: Yu Wenting , Li Shengnan , Zhang Guohao , Xu Hockin H. K. , Zhang Ke , Bai Yuxing
Published: October 2022

Extracellular vesicles (EVs) are a class of nanoparticles that are derived from almost any type of cell in the organism tested thus far and are present in all body fluids. With the capacity to transfer “functional cargo and biological information” to regulate local and distant intercellular communication, EVs have developed into an attractive focus of research for various physiological and pathological conditions. The oral cavity is a special organ of the human body. It includes multiple types of tissue, and it is also the beginning of the digestive tract. Moreover, the oral cavity harbors thousands of bacteria. The importance and particularity of oral function indicate that EVs derived from oral cavity are quite complex but promising for further research. This review will discuss the extensive source of EVs in the oral cavity, including both cell sources and cell-independent sources. Besides, accumulating evidence supports extensive biomedical applications of extracellular vesicles in oral tissue regeneration and development, diagnosis and treatment of head and neck tumors, diagnosis and therapy of systemic disease, drug delivery, and horizontal gene transfer (HGT). The immune cell source, odontoblasts and ameloblasts sources, diet source and the application of EVs in tooth development and HGT were reviewed for the first time. In conclusion, we concentrate on the extensive source and potential applications offered by these nanovesicles in oral science.
An interactive analysis of the mouse oviductal miRNA profiles
Authors: Taraschi Angela , Cimini Costanza , Colosimo Alessia , Ramal-Sanchez Marina , Valbonetti Luca , Bernabò Nicola , Barboni Barbara
Published: October 2022

MicroRNAs are small non-coding molecules that control several cellular functions and act as negative post-transcriptional regulators of the mRNA. While their implication in several biological functions is already known, an important role as regulators of different physiological and pathological processes in fertilization and embryo development is currently emerging. Indeed, miRNAs have been found in the oviductal fluid packaged within the extracellular vesicles, which might act as natural nanoshuttles by transporting lipids, proteins, RNA molecules and miRNAs from the oviduct to the gametes or embryos. Here, an exhaustive bibliography search was carried out, followed by the construction of a computational model based on the networks theory in an attempt to recreate and elucidate the pathways potentially activated by the oviductal miRNA. The omics data published to date were gathered to create the Oviductal MiRNome, in which the miRNA target genes and their interactions are represented by using stringApp and the Network analyzer from Cytoscape 3.7.2. Then, the hyperlinked nodes were identified to investigate the pathways in which they are involved using the gene ontology enrichment analysis. To study the phenotypical effects after the removal of key genes on the reproductive system and embryo, knockout mouse lines for every protein-coding gene were investigated by using the International Mouse Phenotyping Consortium database. The creation of the Oviductal MiRNome revealed the presence of important genes and their interactions within the network. The functional enrichment analysis revealed that the hyperlinked nodes are involved in fundamental cellular functions, both structural and regulatory/signaling, suggesting their implication in fertilization and early embryo development. This fact was as well evidenced by the effects of the gene deletion in KO mice on the reproductive system and embryo development. The present study highlights the importance of studying the miRNA profiles and their enormous potential as tools to improve the assisted reproductive techniques currently used in human and animal reproduction.
PDGF-BB signaling via PDGFR-β regulates the maturation of blood vessels generated upon vasculogenic differentiation of dental pulp stem cells
Authors: Zhang Zhaocheng , Warner Kristy A. , Mantesso Andrea , Nör Jacques E.
Published: October 2022

A functional vascular network requires that blood vessels are invested by mural cells. We have shown that dental pulp stem cells (DPSC) can undergo vasculogenic differentiation, and that the resulting vessels anastomize with the host vasculature and become functional (blood carrying) vessels. However, the mechanisms underlying the maturation of DPSC-derived blood vessels remains unclear. Here, we performed a series of studies to understand the process of mural cell investment of blood vessels generated upon vasculogenic differentiation of dental pulp stem cells. Primary human DPSC were co-cultured with primary human umbilical artery smooth muscle cells (HUASMC) in 3D gels in presence of vasculogenic differentiation medium. We observed DPSC capillary sprout formation and SMC recruitment, alignment and remodeling that resulted in complex vascular networks. While HUASMC enhanced the number of capillary sprouts and stabilized the capillary network when co-cultured with DPSC, HUASMC by themselves were unable to form capillary sprouts. In vivo, GFP transduced human DPSC seeded in biodegradable scaffolds and transplanted into immunodeficient mice generated functional human blood vessels invested with murine smooth muscle actin (SMA)-positive, GFP-negative cells. Inhibition of PDGFR-β signaling prevented the SMC investment of DPSC-derived capillary sprouts in vitro and of DPSC-derived blood vessels in vivo. In contrast, inhibition of Tie-2 signaling did not have a significant effect on the SMC recruitment in DPSC-derived vascular structures. Collectively, these results demonstrate that PDGF-BB signaling via PDGFR-β regulates the process of maturation (mural investment) of blood vessels generated upon vasculogenic differentiation of human dental pulp stem cells.
Quantification of oxidative stress in Saccharomyces pastorianus propagation: Gene expression analysis using quantitative reverse transcription polymerase chain reaction and flow cytometry
Authors: Beugholt Alexander , Büchner Kai , Geier Dominik Ulrich , Becker Thomas
Published: October 2022

When confronted with environmental stress, yeast cell reacts, among others, by modifying the expression of specific genes. In this study, gene expression was analyzed via RT-qPCR to quantify the oxidative stress of Saccharomyces pastorianus during yeast propagation as a reaction to different aeration levels. Target genes were identified, and a reference gene system was developed. Fermentation experiments were conducted in shaking flasks, applying different shaking speeds to generate various aeration efficiencies. The cells were sampled at different propagation stages and, additionally to the expression study, analyzed by flow cytometry after staining with dihydroethidium (DHE) to quantify reactive oxygen species (ROS) inside the cells. The results indicate that high oxygen fermentation conditions led to an increased expression of the catalase-A gene CTA1 during propagation. Furthermore, the determination of cell internal ROS shows increasing oxidative stress over the process in accordance with the RT-qPCR measurements.
Theoretical study on photocatalytic performance of ZnO/C2N heterostructure towards high efficiency water splitting
Authors: Liu Meiping , Tang Yong , Yao Haizi , Bai Liuyang , Song Jun , Ma Benyuan
Published: October 2022

The construction of van der Waals heterostructures offers effective boosting of the photocatalytic performance of two-dimensional materials. In this study, which uses the first-principles method, the electronic and absorptive properties of an emerging ZnO/C2N heterostructure are systematically explored to determine the structure’s photocatalytic potential. The results demonstrate that ZnO and C2N form a type-II band alignment heterostructure with a reduced band gap, and hence superior absorption in the visible region. Furthermore, the band edge positions of a ZnO/C2N heterostructure meet the requirements for spontaneous water splitting. The ZnO/C2N heterostructure is known to possess considerably improved carrier mobility, which is advantageous in the separation and migration of carriers. The Gibbs free energy calculation confirms the high catalytic activity of the ZnO/C2N heterostructure for water-splitting reactions. All the aforementioned properties, including band gap, band edge positions, and optical absorption, can be directly tuned using biaxial lateral strain. A suitable band gap, decent band edge positions, high catalytic activity, and superior carrier mobility thus identify a ZnO/C2N heterostructure as a prominent potential photocatalyst for water splitting.
Combating multidrug-resistant Helicobacter pylori with moenomycin A in combination with clarithromycin or metronidazole
Authors: Tseng Yen-Yu , Liou Jyh-Ming , Cheng Wei-Chieh , Hsu Jing-Ting , Hsu Tsui-Ling , Wu Ming-Shiang , Wong Chi-Huey
Published: October 2022

Current treatment of Helicobacter pylori involves a triple therapy comprising one proton pump inhibitor and two other antibiotics; however, the outcomes are limited due to the existence of antibiotic resistant strains. We previously reported that moenomycin A, a cell-wall transglycosylase inhibitor, is highly active against multidrug-resistant Helicobacter pylori. Herein we show that combination of moenomycin A with the protein synthesis inhibitor clarithromycin or metronidazole can synergistically achieve almost 95% eradication of multidrug-resistant Helicobacter pylori. We also found that the moenomycin A-non-susceptible strains of Helicobacter pylori with deletion of transglycosylase exhibit moenomycin A hyposensitivity, faster growth and impaired biofilm formation compared to the parental strain. Overall, the combination of moenomycin A and clarithromycin or metronidazole to achieve a synergistic effect on different targets is a promising treatment for multidrug-resistant Helicobacter pylori.
Facile preparation of Ti3C2Tx sheets by selectively etching in a H2SO4/H2O2 mixture
Authors: Tian Zhengshan , Tian Hao , Cao Kesheng , Bai Suzhen , Peng Qinlong , Wang Yabo , Zhu Qiuxiang
Published: October 2022

MXenes and MXene-based composite materials have potential applications in a wide range of areas due to their unique physical and chemical characteristics. At present, it is still a major challenge to develop a simple, safe, and efficient route to prepare MXenes without using fluorinated etchants. Herein, we design a facile method to prepare Ti3C2Tx MXene sheets by selectively etching Ti3AlC2 powders in an aqueous diluted H2SO4 solution with H2O2 as an oxidant. In a system of H2SO4 and H2O2, an aqueous H2SO4 solution with a concentration of 6 mol/L is a strongly acidic medium with no volatility, and 30% H2O2 acts as a strong green oxidizer without harmful by-products. The experimental process is safe and convenient to conduct in a beaker under a water bath of 40°C. The etching process can be completed in 1 h under the air atmosphere conditions. The experimental results confirmed that the etched Ti3AlC2 powders can be successfully separated into Ti3C2Tx nanosheets under ultrasound treatment without using any intercalation agent. The relevant etching mechanism is may be attributed to the synergy effect of H2SO4 and H2O2, which triggers sequential selective etching of Al layers from the Ti3AlC2 phase. It may provide a new green way to prepare MXene-based materials without using toxic HF or HF-containing etchants.
Right heart failure after left ventricular assist device: From mechanisms to treatments
Authors: Bravo Claudio A. , Navarro Andrew G. , Dhaliwal Karanpreet K. , Khorsandi Maziar , Keenan Jeffrey E. , Mudigonda Parvathi , O'Brien Kevin D. , Mahr Claudius
Published: October 2022

Left ventricular assist device (LVAD) therapy is a lifesaving option for patients with medical therapy-refractory advanced heart failure. Depending on the definition, 5–44% of people supported with an LVAD develop right heart failure (RHF), which is associated with worse outcomes. The mechanisms related to RHF include patient, surgical, and hemodynamic factors. Despite significant progress in understanding the roles of these factors and improvements in surgical techniques and LVAD technology, this complication is still a substantial cause of morbidity and mortality among LVAD patients. Additionally, specific medical therapies for this complication still are lacking, leaving cardiac transplantation or supportive management as the only options for LVAD patients who develop RHF. While significant effort has been made to create algorithms aimed at stratifying risk for RHF in patients undergoing LVAD implantation, the predictive value of these algorithms has been limited, especially when attempts at external validation have been undertaken. Perhaps one of the reasons for poor performance in external validation is related to differing definitions of RHF in external cohorts. Additionally, most research in this field has focused on RHF occurring in the early phase (i.e., ≤1 month) post LVAD implantation. However, there is emerging recognition of late-onset RHF (i.e., > 1 month post-surgery) as a significant cause of morbidity and mortality. Late-onset RHF, which likely has a unique physiology and pathogenic mechanisms, remains poorly characterized. In this review of the literature, we will describe the unique right ventricular physiology and changes elicited by LVADs that might cause both early- and late-onset RHF. Finally, we will analyze the currently available treatments for RHF, including mechanical circulatory support options and medical therapies.
Association between albumin infusion and septic patients with coronary heart disease: A retrospective study based on medical information mart for intensive care III database
Authors: Ye Zhiwen , Gao Ming , Ge Chenglong , Lin Wenrui , Zhang Lina , Zou Yu , Peng Qianyi
Published: October 2022

Coronary heart disease (CHD) is a common comorbidity in intensive care unit (ICU) patients, particularly in the elderly. This particular population may have worse conditions during sepsis, and it presents an overwhelming challenge for clinical practice. Previous studies suggested that patients with CHD have an increased risk of cardiovascular events, and low albumin concentration worsens the prognosis of patients with stable CHD. Hypoalbuminemia in patients with sepsis is common due to nutritional disorders, excessive consumption, and leakage. Albumin is a fluid often used for resuscitation in patients with sepsis. However, albumin infusion in patients with sepsis and CHD has rarely been studied. The effects and safety of albumin infusion in patients with sepsis and CHD remain unclear. Therefore, we collected medical information from Mimic-III (Mimic-III) and compared the all-cause mortality and cardiovascular mortality at 28- or 90-day between the albumin and non-albumin groups in septic patients with CHD. A total of 2,027 patients with sepsis and CHD were included in our study, with 405 in the albumin group and 1,622 in the non-albumin group. After propensity score matching (PSM), 350 pairs were included in our study. Improved survival benefits were found in the albumin group at the 28-day all-cause mortality compared with the non-albumin group (hazard ratio [HR], 0.54; 95% CI: 0.38–0.78; p = 0.0009). However, no difference was detected in the 90-day survival benefits (HR, 0.80, 95% CI: 0.60–1.06, p = 0.1207). Albumin infusion did not reverse cardiovascular mortality neither at 28th day nor at 90th day (cardiovascular mortality: 28 days, HR, 0.52, 95% CI: 0.23–1.19, p = 0.1218; 90 days, HR, 0.66, 95% CI: 0.33–1.33, p = 0.2420).