bluuebunny/crossref_metadata_2025 huggingface dataset:
The impact of fear in the post covid era
Authors: Díez González María del Carmen , Sánchez Rafael Marcos
Published: December 2021

Feeling fear is involuntary, as it is often unconscious. However, there are other faces of fear that we can recognize and that are familiar to us. We go from real fears to unreal fears, from present fears to projective fears that are reinforced and mutate into other more complex situations that further reinforce our fear. The more we reinforce these thoughts the stronger our fear becomes. So, what is feeding our fear? How do we react to fear? Is it the desire to dodge the blow, to strike back, to attack it? Fear is a very powerful mechanism that should only be activated in dangerous situations. If we use fear for educational purposes we will project very deep blockages in the new generations. However, when we recognize and accompany the thoughts and impulses generated by fear, they become silent. Once silenced, they are no longer activated unconsciously. Therefore, if we look at what is happening, consciously, "without judgement" it will facilitate our journey towards our true SELF. The EmocionaTFamilia program invites us to accompany our path "lightly and at the right time". Change is simple, the lesson is the opposite of what we have learned.
Spatial Clustering of Vaccine Exemptions on the Risk of a Measles Outbreak
Authors: Gromis Ashley , Liu Ka-Yuet
Published: December 2021

OBJECTIVES

Areas of increased school-entry vaccination exemptions play a key role in epidemics of vaccine-preventable diseases in the United States. California eliminated nonmedical exemptions in 2016, which increased overall vaccine coverage but also rates of medical exemptions. We examine how spatial clustering of exemptions contributed to measles outbreak potential pre- and postpolicy change.

METHODS

We modeled measles transmission in an empirically calibrated hypothetical population of youth aged 0 to 17 years in California and compared outbreak sizes under the observed spatial clustering of exemptions in schools pre- and postpolicy change with counterfactual scenarios of no postpolicy change increase in medical exemptions, no clustering of exemptions, and lower population immunization levels.

RESULTS

The elimination of nonmedical exemptions significantly reduced both average and maximal outbreak sizes, although increases in medical exemptions resulted in more than twice as many infections, on average, than if medical exemptions were maintained at prepolicy change levels. Spatial clustering of nonmedical exemptions provided some initial protection against random introduction of measles infections; however, it ultimately allowed outbreaks with thousands more infections than when exemptions were randomly distributed. The large-scale outbreaks produced by exemption clusters could not be reproduced when exemptions were distributed randomly until population vaccination was lowered by >6 percentage points.

CONCLUSIONS

Despite the high overall vaccinate rate, the spatial clustering of exemptions in schools was sufficient to threaten local herd immunity and reduce protection from measles outbreaks. Policies strengthening vaccine requirements may be less effective if alternative forms of exemptions (eg, medical) are concentrated in existing low-immunization areas.
Renal Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference
Authors: Fitzgerald Julie C. , Basu Rajit K. , Fuhrman Dana Y. , Gorga Stephen M. , Hassinger Amanda B. , Sanchez-Pinto L. Nelson , Selewski David T. , Sutherland Scott M. , Akcan-Arikan Ayse
Published: December 2021

CONTEXT

Renal dysfunction is associated with poor outcomes in critically ill children.

OBJECTIVE

To evaluate the current evidence for criteria defining renal dysfunction in critically ill children and association with adverse outcomes. To develop contemporary consensus criteria for renal dysfunction in critically ill children.

DATA SOURCES

PubMed and Embase were searched from January 1992 to January 2020.

STUDY SELECTION

Included studies evaluated critically ill children with renal dysfunction, performance characteristics of assessment tools for renal dysfunction, and outcomes related to mortality, functional status, or organ-specific or other patient-centered outcomes. Studies with adults or premature infants (≤36 weeks' gestational age), animal studies, reviews, case series, and studies not published in English with inability to determine eligibility criteria were excluded.

DATA EXTRACTION

Data were extracted from included studies into a standard data extraction form by task force members.

RESULTS

The systematic review supported the following criteria for renal dysfunction: (1) urine output <0.5 mL/kg per hour for ≥6 hours and serum creatinine increase of 1.5 to 1.9 times baseline or ≥0.3 mg/dL, or (2) urine output <0.5 mL/kg per hour for ≥12 hours, or (3) serum creatinine increase ≥2 times baseline, or (4) estimated glomerular filtration rate <35 mL/minute/1.73 m2, or (5) initiation of renal replacement therapy, or (6) fluid overload ≥20%. Data also support criteria for persistent renal dysfunction and for high risk of renal dysfunction.

LIMITATIONS

All included studies were observational and many were retrospective.

CONCLUSIONS

We present consensus criteria for renal dysfunction in critically ill children.
Coagulation Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference
Authors: Faustino E. Vincent S. , Karam Oliver , Parker Robert I. , Hanson Sheila J. , Brandão Leonardo R. , Monagle Paul ,   Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Collaborative
Published: December 2021

CONTEXT

Previous criteria for coagulation dysfunction in critically ill children were based mainly on expert opinion.

OBJECTIVE

To evaluate current evidence regarding coagulation tests associated with adverse outcomes in children to inform criteria for coagulation dysfunction during critical illness.

DATA SOURCES

Electronic searches of PubMed and Embase were conducted from January 1992 to January 2020 by using a combination of medical subject heading terms and text words to define concepts of coagulation dysfunction, pediatric critical illness, and outcomes of interest.

STUDY SELECTION

Studies were included if critically ill children with coagulation dysfunction were evaluated, if performance characteristics of assessment and/or scoring tools to screen for coagulation dysfunction were evaluated, and if outcomes related to mortality or functional status, organ-specific outcomes, or other patient-centered outcomes were assessed.

DATA EXTRACTION

Data were abstracted from each eligible study into a standard data extraction form, along with risk of bias assessment, by a task force member.

RESULTS

The systematic review supports the presence of at least 2 of the following criteria reflecting coagulation dysfunction in the absence of liver dysfunction: platelet count <100 000 cells per μL, international normalized ratio >1.5, fibrinogen level <150 mg/dL, and D-dimer value above 10 times the upper limit of normal, or above the assay’s upper limit of detection if this limit is below 10 times the upper limit of normal.

LIMITATIONS

The proposed criteria for coagulation dysfunction are limited by the available evidence and will require future validation.

CONCLUSIONS

Validation of the proposed criteria and identified scientific priorities will enhance our understanding of coagulation dysfunction in critically ill children.
Immune System Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference
Authors: Hall Mark W. , Carcillo Joseph A. , Cornell Timothy
Published: December 2021

CONTEXT

Immune system dysfunction is poorly represented in pediatric organ dysfunction definitions.

OBJECTIVE

To evaluate evidence for criteria that define immune system dysfunction in critically ill children and associations with adverse outcomes and develop consensus criteria for the diagnosis of immune system dysfunction in critically ill children.

DATA SOURCES

We conducted electronic searches of PubMed and Embase from January 1992 to January 2020, using medical subject heading terms and text words to define immune system dysfunction and outcomes of interest.

STUDY SELECTION

Studies of critically ill children with an abnormality in leukocyte numbers or function that is currently measurable in the clinical laboratory in which researchers assessed patient-centered outcomes were included. Studies of adults or premature infants, animal studies, reviews and commentaries, case series (≤10 subjects), and studies not published in English with inability to determine eligibility criteria were excluded.

DATA EXTRACTION

Data were abstracted from eligible studies into a standard data extraction form along with risk of bias assessment by a task force member.

RESULTS

We identified the following criteria for immune system dysfunction: (1) peripheral absolute neutrophil count <500 cells/μL, (2) peripheral absolute lymphocyte count <1000 cells/μL, (3) reduction in CD4+ lymphocyte count or percentage of total lymphocytes below age-specific thresholds, (4) monocyte HLA-DR expression <30%, or (5) reduction in ex vivo whole blood lipopolysaccharide-induced TNFα production capacity below manufacturer-provided thresholds.

LIMITATIONS

Many measures of immune system function are currently limited to the research environment.

CONCLUSIONS

We present consensus criteria for the diagnosis of immune system dysfunction in critically ill children.
Endothelial Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference
Authors: Pierce Richard W. , Giuliano John S. , Whitney Jane E. , Ouellette Yves ,   Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Collaborative
Published: December 2021

OBJECTIVES

To review, analyze, and synthesize the literature on endothelial dysfunction in critically ill children with multiple organ dysfunction syndrome and to develop a consensus biomarker-based definition and diagnostic criteria.

DATA SOURCES

Electronic searches of PubMed and Embase were conducted from January 1992 to January 2020, using a combination of medical subject heading terms and key words to define concepts of endothelial dysfunction, pediatric critical illness, and outcomes.

STUDY SELECTION

Studies were included if they evaluated critically ill children with endothelial dysfunction, evaluated performance characteristics of assessment/scoring tools to screen for endothelial dysfunction, and assessed outcomes related to mortality, functional status, organ-specific outcomes, or other patient-centered outcomes. Studies of adults or premature infants (≤36 weeks gestational age), animal studies, reviews or commentaries, case series with sample size ≤10, and non-English language studies with the inability to determine eligibility criteria were excluded.

DATA EXTRACTION

Data were abstracted from each eligible study into a standard data extraction form along with risk of bias assessment.

DATA SYNTHESIS

We identified 62 studies involving 84 assessments of endothelial derived biomarkers indirectly linked to endothelial functions including leukocyte recruitment, inflammation, coagulation, and permeability. Nearly all biomarkers studied lacked specificity for vascular segment and organ systems. Quality assessment scores for the collected literature were low.

CONCLUSIONS

The Endothelial Subgroup concludes that there exists no single or combination of biomarkers to diagnose endothelial dysfunction in pediatric multiple organ dysfunction syndrome. Future research should focus on biomarkers more directly linked to endothelial functions and with specificity for vascular segment and organ systems.
Análise da utilização de símbolos religiosos em espaços públicos brasileiros
Authors: Guimarães Vânio Soares
Published: December 2021

A análise dos conceitos de laicidade e laicismo são imprescindíveis para o entendimento da permissão de utilização de símbolos religiosos em espaços públicos, dada pelo Conselho Nacional de Justiça, nos Pedidos de Providência de números 1.344, 1.345, 1.346 e 1.362, julgados em 29 de maio de/2007, diante de provocação feita para retirada de um crucifixo na sede do Tribunal Regional Eleitoral de São Paulo. Mostra-se que o laicismo é uma visão acentuada contra toda e qualquer manifestação religiosa no campo público, não atendendo ao objetivo do constituinte originário quando da promulgação da Constituição Federal de 1988, em especial pela redação do art. 19, I, do Texto Maior, que evoca a laicidade estatal e não o laicismo. A compreensão para a permissão de símbolos religiosos em espaços públicos é a que invoca a memória cultural, ideia bem elucidada por Jan Assmann, com noção de tradição e pertencimento. Assim, após elucidação científica sobre tal identidade cultural, busca-se demonstrar que a laicidade não impede a permanência de símbolos religiosos em espaços públicos e que a tolerância deve imperar, como mecanismo de educação para a paz.
Liturgia em tempos de pandemia
Authors: Temochko Arnaldo
Published: December 2021

O presente artigo aborda a Liturgia das Horas como uma possibilidade de oração eclesial para as famílias nos tempos de pandemia. A finalidade é apresentar aspectos teológicos e pastorais a fim de que a Liturgia das Horas seja mais valorizada na vida litúrgica das famílias e das comunidades durante a pandemia e, também, depois dela. Para tanto, apresenta-se o tema em três momentos: a) por meio das Constituições Apostólicas e a Peregrinação de Etéria, ambos documentos patrísticos do século IV, busca evidenciar a forma como a participação de toda a comunidade eclesial era frequente nas primícias do cristianismo; b) analisando a Sacrosanctum Concilium e a Instrução Geral da Liturgia das Horas destaca-se a insistência da Igreja a fim de que todos os fiéis tenham o devido acesso ao tesouro desta forma de oração; c) por fim, são levantados caminhos pelos quais a Liturgia das Horas pode chegar ao seio das famílias, bem como os benefícios espirituais que isso pode promover. Após a reflexão constata-se que ainda há um longo caminho a ser percorrido a fim de que a Liturgia das Horas possa se reaproximar do povo de Deus.
Hospitalidade compassiva
Authors: Mattiello Giovani Adelino
Published: December 2021

Diante de uma sociedade em transformação, afetada drasticamente pela pandemia do Covid-19, esse artigo aborda o tema da hospitalidade em sua vocação acolhedora e prestativa como modelo a guiar o surgimento de novo paradigma para as relações humanas. A hospitalidade é caracterizada como uma norma social que está presente em diversas culturas e tradições, especialmente na tradição bíblica, onde é fundamentada como um mandamento divino. Nos escritos neotestamentários, Jesus apresenta o evangelho do Reino, em um contexto que ressignifica o amor a Deus e ao próximo. Assim, frustrando diversas expectativas de seu tempo, Jesus revela um Reino onde ao mesmo tempo se coloca como hóspede, no despojamento e na simplicidade de ser acolhido, e anfitrião, oferecendo guarida ao povo excluído e marginalizado. Apresenta-se a parábola do bom samaritano (Lc 10, 25-37) como uma súmula e modelo da misericórdia de Deus que reivindica também uma atitude de compaixão para com o próximo. Desse modo, Jesus apresenta uma hospitalidade compassiva, guiada pelo horizonte mais abrangente e inclusivo do amor. Temos, assim, a partir da ideia de hospitalidade compassiva, valores que se oferecem para refletir os tempos hodiernos, em suas crises e esperanças.
Prática freelancer em design: os efeitos da falta de formalização na prestação de serviços
Authors: Bento dos Santos Letícia , Lopes Damasceno Patrícia
Published: December 2021

Resumo: Este artigo apresenta uma pesquisa acerca do profissional freelancer em design em um contexto local, a qual foi realizada como parte de um Trabalho de Conclusão de Curso defendido junto ao curso de Design Digital da Universidade Federal de Pelotas. Isso posto, discute-se aqui a prática profissional freelancer em design através de pesquisa bibliográfica e documental, a fim de compreender certos aspectos característicos do freelancer brasileiro. Em seguida, apresenta-se algumas das problemáticas encontradas por eles frente à precarização do trabalho e falta de formalização contratual. Posteriormente, expõe-se os resultados obtidos por meio da aplicação de um questionário direcionado a designers locais e elenca-se quais elementos são necessários para a formulação de um termo de compromisso.

Palavras-chave: Freelancer; Design; Prática profissional; Prestação de serviços; Termo de compromisso.
Design e Branding Sensorial: estudo de caso sobre as lojas Ramsons Manaus
Authors: Venturelli Ribeiro Eduarda , Furtado Gerfeson , Mazarelo Karla
Published: December 2021

Em vista de uma sociedade globalizada, em que empresas necessitam diferenciar-se das demais, esta pesquisa tem por objetivo apontar possíveis mudanças que fortaleçam uma relação emocional e física entre as lojas Ramsons, situadas em Manaus, e seus clientes através de aspectos do branding design.  A pesquisa faz uso de uma abordagem qualitativa, com objetivos de caráter exploratório e descritivo, fundamentados em levantamento de dados bibliográficos, observação em campo, realização de estudo de caso e consulta de opinião através de questionário online e grupo focal. Como resultados, foram identificados os aspectos sensoriais necessários à Ramsons e indicações de melhorias para a consolidação dessa relação emocional dos consumidores com a empresa varejista.
Requisitos para o design de um artefato digital de suporte à gestão de resgate e adoção de animais
Authors: Melo Priscila Cristiane Bandeira de , Silva Bruno Santana da
Published: December 2021

Este trabalho relata um estudo de caso que investigou em profundidade atividades e informações envolvidas no processo de resgate e adoção de animais. Fluxogramas e dicionário de dados foram elaborados, discutidos e revisados em grupos focais com participantes de um projeto de extensão universitária. Como resultado, foram identificados 41 requisitos funcionais para orientar o design de um artefato digital de apoio à gestão do resgate e adoção de animais. Destes, 21 requisitos foram priorizados para a primeira versão do artefato digital, também chamada de mínimo produto viável. Os resultados deste trabalho servem como importante subsídio para a concepção futura do processo de interação e interface de um artefato que permita ao usuário usufruir dos benefícios das tecnologias digitais com uma boa experiência de uso.
Pengaruh pengapuran dan pemupukkan P, K terhadap produktivitas dan kualitas buah papaya CV. Merah Muda di lahan rawa
Authors: Purnama Titin , Hendri Hendri , Jumjunidang Jumjunidang , Fatri D , Sparta Andre
Published: December 2021

Pepaya Merah Delima berpotensi untuk dibudidayakan di lahan rawa lebak. Permasalahan lahan rawa lebak yaitu pH rendah dan ketersediaan hara dalam tanah rendah sehingga perlu diberikan pengapuran dan pemupukan tambahan. Penelitian ini bertujuan untuk mendapatkan dosis kapur, pupuk P dan K terbaik untuk meningkatkan produktivitas dan kualitas pepaya Merah Delima. Penelitian dilakukan di lahan rawa lebak TTP Siak, Kecamatan Sai Mandau (BPTP Riau) dari bulan Januari 2018 sampai Desember 2019. Penelitian menggunakan Rancangan Petak Terbagi dengan petak utama yaitu dua taraf dosis kapur (6 dan 9 t ha-1) dan anak petak kombinasi dari tiga taraf dosis pupuk P2O5 (100, 200, 300 g tan-1) dan tiga taraf dosis pupuk K2O (150, 300, 450 g tan-1), setiap perlakuan terdapat tiga ulangan. Hasil penelitian menunjukkan pemberian kapur dosis 6 t ha-1 dan kombinasi P dan K dosis 300 g tan-1+ 300 g tan-1 berturut-turut, dapat meningkatkan produksi pepaya Merah Delima sampai 51% dengan rata-rata produksi 98,00 kg tan-1, jumlah buah rata-rata 95,45 tan-1, bobot buah 1.031,30 g buah-1, PTT 11,81 oBrix, dan kekerasan buah 55,08 kg cm-2. Pemberian kapur dan tambahan pupuk P dan K efektif untuk memperbaiki sifat lahan rawa lebak sehingga dapat meningkatkan hasil tanaman pepaya Merah Delima. Papaya CV. Merah Delima is potential to be cultivated on tidal swampland. The problems of tidal swampland are low degree of pH and low nutrient availability in the soil, thus it needs additional liming and fertilization. This study aimed to obtain the best dose of lime, also phosphorus and potassium fertilizers to increase the productivity and quality of papaya cv. Merah Delima. The study was conducted at TTP Siak, Sai Mandau district (BPTP Riau) from January 2018 to December 2019. The study used a Split Plot Design with the main plot was two doses of lime (6 and 9 t ha-1) and the subplot was combination of three doses of P2O5 fertilizer (100, 200, 300 g plant-1) and three levels of K2O fertilizer (150, 300, 450 g plant-1), with three replications. The results showed the application of lime at dose of 6 t ha-1 combined by P and  K fertilizer of 300 g plant-1 + 300 g plant-1, respectively, could increase papaya production up to 51%, whereas average production 98.00 kg plant-1, average number of fruits 95.45 plant-1, fruit weight 1,031.30 g fruit-1, TSS 11.81 °Brix, and fruit hardness of 55.08 kg cm-2. Application of lime and additional fertilizer into the tidal swampland are effective to improve its characteristics and able to increase the papaya Merah Delima production.
Pengaruh pemupukan N terhadap serapan dan efisiensi penggunaan N, serta hasil padi hibrida
Authors: Syarifah Risqa Naila Khusna , Ulinuha Zulfa , Purwanto Purwanto
Published: December 2021

Pemupukan N pada padi hibrida menjadi krusial mengingat varietas padi hibrida sangat responsif, sehingga harus diketahui dosis yang tepat untuk menghasilkan produksi yang tinggi. Penelitian ini bertujuan untuk mengkaji pengaruh dosis N terhadap serapan N, efisiensi penggunaan N, dan hasil padi hibrida. Penelitian menggunakan Rancangan Acak Kelompok yang diulang tiga kali. Faktor pertama adalah varietas padi hibrida yang terdiri dari Varietas Mapan P05, Varietas SL-8 SHS Sterling, dan Varietas Intani 602. Faktor kedua adalah dosis pemupukan N yang terdiri dari kontrol tanpa pemupukan N, dosis N 100 kg ha-1, dan dosis N 200 kg ha-1. Terdapat respon yang beragam antar varietas padi hibrida terhadap taraf pemupukan N, Serapan N, efisiensi penggunaan N tertinggi yang dihasilkan oleh varietas Intani 602 masing-masing sebesar 138,57 %, dan 36,13%. Serapan N tanaman padi tertinggi dicapai pada dosis N 100 kg ha-1, dan efisiensi penggunaan N tertinggi pada dosis N 200 kg ha-1. Hasil gabah tertinggi dicapai pada varietas Mapan P05 sebesar 7,42 t ha-1, dan dosis pemupukan N 100 kg ha-1 memberikan hasil tertinggi sebesar 7,47 t ha-1. Implikasi dari penelitian ini bahwa dosis nitrogen 100 kg ha-1 dapat menjadi acuan sebagai dosis pemupukan N varietas padi hibrida di Indonesia. Hybrid rice is responsive to nitrogen, so it’s necessary to find the optimum dose to optimize the production. The  aim of this research was to examine the effect of nitrogen on N uptake, N use efficiency, and yield of hybrid rice. This study used a randomized block design with three replications. The first factor consisted of the  Mapan P05 variety, the SL-8 SHS Sterling variety, and Intani 602 variety. The second factor was Nitrogen dosage consisted of control, 100 kg ha-1, and 200 kg ha-1. There were various responses among hybrid rice varieties to the level of fertilization. The highest N uptake and N use efficiency was achieved in the Intani 602 variety at 138.57% and 36.13%, respectively. The highest N uptake was achieved at 100 kg ha-1 of N, and the highest N use efficiency was at 200 kg ha-1. The highest yield was achieved in the Mapan P05 variety (7.42 t ha-1), and the dose of N at 100 kg ha-1 gave the highest yield (7.47 t ha-1). The implication of this research is that the nitrogen dose of 100 kg ha-1 can be used as a reference for hybrid rice varieties fertilizer in Indonesia.
STUDI PERENCANAAN BANGUNAN PELINDUNG PANTAI UNTUK PENANGGULANGAN ABRASI DI PANTAI UTARA KARAWANG
Authors: Pasaribu Roberto Patar , Irwan Asep , Pattirane Chrisoetanto
Published: December 2021

Pantai Karawang adalah pantai yang dipengaruhi aktifitas hidro-oseanografi yang terjadi disepanjang pantai seperti arus, gelombang dan pasang surut. Akibat dari himpasan gelombang laut dan transport sedimen mengakibatkan terjadinya abrasi dan sedimentasi yang menimbulkan kerusakan disepanjang pantai. Untuk  melindungi pantai dari kerusakan yang diakibatkan abrasi dilakukan dengan membuat bangunan pelindung pantai. Bangunan pantai adalah segala jenis infrastruktur yang dibangun di garis pantai dan dapat berfungsi sebagai pelindung pantai. Bangunan ini berfungsi untuk mengurangi besarnya gelombang yang sampai di pantai. Beberapa contoh bangunan pelindung pantai adalah Breakwater dan Groin. Penelitian ini bertujuan merencanakan bangunan pelindung pantai untuk penanggulangan abrasi yang terjadi di pantai utara kabupaten Karawang. Data yang digunakan adalah data hidro-oseanografi seperti gelombang, arus, pasang surut dan batimetri, sedangkan untuk pengolahan data digunakan aplikasi GENESIS. Berdasarkan hasil perhitungan dan analisa data serta kondisi pantai, bangunan pelindung pantai yang direncanakan adalah breakwater dengan letak dan dimensi bangunan adalah: jarak bangunan dari pantai 50 meter, tinggi bangunan 6 meter, panjang bangunan 100 meter, jarak antara bangunan 20 m.
Penambahan Tepung Gracilaria sp. Terhadap Karakteristik Produk Terpilih Bakso Ikan Nila (Oreochromis niloticus)
Authors: Sipahutar Yuliati Hotmauli , Alhadi Hasby ‘Arif , Arridho Ahmad Ali , Asyurah M Chairil , Kilang Kisfina , Azminah Nina
Published: December 2021

Penelitian ini bertujuan untuk mengetahui efek penggunaan bahan tambahan makanan tepung Gracilaria sp. terhadap karakteristik hedonik produk bakso nila terpilih. Rumput laut Gracilaria sp. diperoleh langsung dari budidaya rumput laut di perairan Kabupaten Karawang. Penelitian ini dilakukan eksperimen rancangan acak lengkap (RAL) dengan perlakuan penambahan lima konsentrasi tepung rumput laut Gracilaria sp. 0%, 6%, 12%, 18%, dan 24%, dengan tiga kali ulangan. Parameter uji dilakukan dengan uji hedonik, uji kimia (kadar air, kadar abu, kadar lemak, kadar protein dan kadar serat pangan) dan uji mikrobiologi ALT, Salmonella dan Escherichia coli. Analisa data dilakukan dengan analisis deskriptif. Hasil yang terpilih untuk bakso ikan nila dengan penambahan tepung  rumput laut Gracilaria sebesar 6%, dengan nilai kenampakan 7,35, bau 7,46, rasa 7,43, tekstur 7,48. Uji kimia diperoleh hasil kadar air 61,51%, kadar abu 0,98%, kadar protein 23,98%, lemak 0,38%, serat kasar 1,82%. Uji mikrobiologi ALT adalah 3,3 x 103 koloni/g, Escherichia coli negatif dan Salmonella negatif. Penambahan tepung Gracilaria sp. sebagai bahan tambahan untuk bakso akan meningkatkan tekstur bakso ikan nila.
Marine-Sediment Characteristics and Thickness Over The Eroded Sayung Coast, Demak, Indonesia
Authors: Gemilang Wisnu Arya , Wisha Ulung Jantama , Rahmawan Guntur Adhi , Ondara Koko
Published: December 2021

An over whelming erosion occurred in Sayung waters is related to sedimentary processes. That is why the deeper determination of sediment characteristics through direct survey and acoustic data retrieval is crucial. Several previous related studies had been conducted revealing the rate and model of sedimentation. This study aimed to describe the sedimentary processes according to its features and deposition. In this study, we conducted a grab-sampling, bathymetry surveys and also hydrodynamical model. Grain size analysis was employed to observe the characteristics of sediment and its deposition environment. At the same time, we applied dual-frequency bathymetry data for estimating sediment thickness which reflects the accumulation sediment over Sayung waters. We found that sediment texture varies from sand to clay, while coarse sediment fraction is dominant in the western part. Near the coastline area of Sayung waters reflecting the more potent transport mechanism in the deposition environment, proven by the less-accumulated sediment from 0-2.5 km from the coastline. In sea-ward regions, we observed the finer sediment fraction, showing that the low-transport mechanism takes place. The topographical alteration has intensively occurred at 2.5-3.2 km from the coastline. Tidal current has an essential role in inducing local transport whereby the speed varies ranging from 0-0.14 m/s, other than that, the more substantial current features have observed in Surodadi and Bedono coast moving perpendicularly toward the beach. In contrast, in the southern Sayung waters, the current profiles tend to be weak inducing higher sedimentation. Besides, the emergence of the sandbar has a role in reflecting sediment texture predomination in Sayung waters.
Identifying Priority Areas for Coastal Protection Around Java, Indonesia
Authors: Kalther Jimy , Itaya Akemi
Published: December 2021

Climate change-induced sea level rise will likely increase the severity of ongoing coastal disasters in Indonesia. The selection and concentration approach should be applied to minimize the costs of conservation when budgets are limited. Prioritizing is then effective in terms of cost effectiveness. We aimed to identify priority areas for coastal protection against sea level rise around Java, Indonesia, using the Marxan model. The model uses systematic planning to select prioritized areas for coastal protection. Three scenarios were developed based on ecological, economic, and disaster elements that were exacerbated by sea level rise. A scenario is defined as a particular simulation circumstance based on assumptions about extrinsic drivers, parameters, and the structure of the model. Coastline length, mangrove coverage, low-elevation area, fishpond area, human settlement area, and the area of zones with the potential for annual rainfall increases acquired from DIVA-GIS and WorldClim were set as environmental factors. There were 60 areas facing the coast among 117 areas. For those protection, it would be fairly costly. We were able to narrow that number down from 18.8% to 62.4% from 117 areas using our method. This might become very cost effective. The most prioritized areas were located in the northern region of Java. These areas can be a focus of preferential effort and funding for conservation. The results of this study will help to make the protection strategy based on not only the magnitude of damage but also the total perspective using public data that is relatively easy to obtain.
Distribution of Tide Type in Indonesian Waters Based on 7 Days Data Measurement of Ipasoet-BIG Station
Authors: Ramdhan Muhammad , Yulius Yulius , Oktaviana Nindya Kania
Published: December 2021

Tidal data is needed in the field of energy, marine navigation, coastal construction and other activities related to the oceans. Tidal phenomena occur due to the interaction of the earth with space objects. The sea level rise in coastal waters can be modeled by a harmonic function containing tidal constant numbers. From the constants formed can be calculated a Formzahl number that shows the type of tides that occur at the observation station. This paper tries to describe the distribution pattern of tidal types that exist in Indonesian waters based on data observation collected at station belong to  the Geospatial Information Agency. The result is that there are 4 types of tides in Indonesian waters, with the most dominant distribution are  mixed tide, prevailing semi diurnal typel.
Seagrass Condition at Some Small Islands in The Taka Bonerate National Marine Park, South Sulawesi Indonesia
Authors: Supriyadi Indarto Happy , Cappenberg Hendrik Alexander William , Wouthuyzen Sam , Hafizt Muhammad , Rahmawati Susi , Alifatri La Ode , Suyarso Suyarso
Published: December 2021

The assessment of seagrass bed condition in Indonesia still refers to the Decree of the State Minister for the Environment (KMNLH) no. 200 of 2004, which considers only one variable, namely the percentage of seagrass cover. To assess the seagrass beds condition to be more in-depth and meaningful, it is necessary to consider the addition of several variables, such as the biotic variables (seagrass species diversity including macroalgae and macro-benthos components) as well as the abiotic variables (reef flat areas and the substrate components). The purpose of this study is to determine the seagrass beds condition in several small islands in the Taka Bonerate National Marine Park by considering the additional analysis using both biotic and abiotic variables as mentioned above. The methodology used in this study is a combination of the use of the standard seagrass transect method, interpretation of satellite imagery related to the seagrass bottom habitat area, and its components on the reef flat of a particular island, as well as weighting and scoring based on those considered additional variables. By applying the criteria in the method, the seagrass bed conditions were then classified into three categories, namely seagrass in good, moderate, and unfavorable conditions, respectively. The results of the total score assessment on several small islands in Taka Bonerate Islands show that the seagrass bed in Latondu Besar Island is in good conditions with the highest score of (316) compared to Tarupa Besar, Jinato, Rajuni Kecil, and Tinabo Besar Islands with an average score of (173). The results of this study indicate that the assessment of seagrass conditions is more meaningful in terms of seagrass ecology than based on seagrass cover alone. However, this study requires a lot of validation for its application in assessing the condition of seagrass beds in other islands in Indonesia.
Land Use Changes Analysis in Jakarta Bay Coastal Area Between 1998, 2008 and 2018
Authors: Rizal Anwar
Published: December 2021

As the national capital and one of the largest cities in the world, environmental conditions and land use in Jakarta have changed a lot in the last twenty years. Economic growth and high population growth in Jakarta have resulted in massive development of infrastructure and residential areas in Jakarta. Economic growth and an increase in population are become problems, especially with the decreasing of green areas due to the development process carried out without paying attention to the surrounding environment. Environmental problems such as water pollution, land subsidence, coastal erosion and flooding often occur in the Jakarta area, especially in the coastal areas of North Jakarta. The research from 1998 to 2018 show that from the observations area of mangrove land cover has increased by 79 hectares during that period. The same trend applied on area of built and open land that increased by 292 hectares and 887 hectares respectively. Meanwhile, the area of land for vegetation, water bodies, and fishpond has decreased from 1998 to 2018 by 393 hectares, 797 hectares and 309 hectares respectively. Development and reclamation have changed land use in the Northern area of Jakarta. However, it is also necessary to pay attention to the impact of development on environmental and social conditions in the North Jakarta area.
\(\textit{Nervilia kasiensis}\) (Orchidaceae), a new record for the flora of Vietnam
Authors: Cong Vu Kim , Vinh Tran Thai , Bing H’Yon Nie , Tham Dang Thi , Hoi Quach Van , Duy Nong Van
Published: December 2021

Nervilia kasiensis is reported here as a new record for the flora of Vietnam. It is illustrated with detailed photographs made in the field. A key for the identification of all species of Nervilia genus known in Vietnam is presented.
Construction of fine resolution bioclimatic variables for Central Highlands and Southern Central Coast of Vietnam
Authors: Viet Phan Bach , Duc Hoang Minh , Bang Tran Van , Truong Luu Hong , Quang Nguyen Dang , Phong Diep Dinh
Published: December 2021

In this study, 19 surface bioclimatic variables of high spatial resolution 0.00226o (~ 250 m) are generated in a Geographic Information System by the combination of (1) the raster dataset of monthly temperature and precipitation obtained from the global WorldClim database at 0.00833o spatial resolution for the period of 1960–2000; and (2) the climate data (temperature and precipitation) of the Central Highlands and Southern Central Coast collected from the 31 temperature and 97 precipitation recording sites for the period of 1991–2015. The statistical downscaling method is applied, using multiple linear regression analysis, in which elevation, geographic coordinates, and distance from the coast are treated as independent variables, to estimate the distribution of temperature; and the B-Spline interpolation method combined with multiple linear regression analysis is employed on precipitation over the study area. The outcomes of the two main analyses are computed to create 19 high spatial resolution bioclimatic variables. While using only local climate data on analyzing the regression models results in high fluctuation of estimated temperature, the combination of the two datasets is more informative. The spatial distribution of our interpolated precipitation is similar to the WorldClim data but has a smaller difference in the mean annual precipitation. The results, which shows higher spatial resolution and are closer to the observed data than those from the WorldClim, could be better applied for predicting species distribution in the region.
Efficiency assessment of microplastic extraction from green mussel \(\textit{Perna viridis}\) Linnaeus
Authors: Oanh Doan Thi , Thuy Duong Thi , Huong Nguyen Thi Nhu , Quynh Hoang Thi , Nguyet Vu Thi , Nam Phuong Ngoc , Tuan Pham Quoc , Thinh Ngo Thi Xuan , Thuong Bui Huyen , Quynh Le Thi Phuong
Published: December 2021

Microplastics with particle size less than 5 mm are becoming a raising global environmental crisis. These pollutants were found from the poles to the equator, in continental shelves, coasts and in the oceans, moreover, they have also been identified in the water columns, sediments and even in a variety of organisms. The majority of microplastics that ended up in the oceans originate from the land. Due to their small size, they are easily accumulated in the food chain, causing harmful effects on organisms and human health. The bivalves especially caught the interest of scientific researchers because of their direct contact with microplastics through the filter-feeding habit. Therefore, it is essential to develop methods to determine the presence of microplastics in these organisms and identify their source. This study evaluated the efficiency of extracting microplastics from the tissues of green mussels (Perna viridis) using KOH 10% solution to digest and KI 50% as the separating solution. Mussel soft tissue samples were spiked five different types of microplastics: polystyrene (PS), polyvinyl chloride (PVC), polyethylene terephthalate (PET), polypropylene (PP), high-density polyethylene (HDPE) and treated with KOH 10% solution and KI 50% solution. The presence of microplastics in some green mussel species was also investigated in some mussel farming areas in Giao Thuy, Nam Dinh province, Thi Nai, Quy Nhon, Binh Dinh province and Hue city, Thua Thien Hue province. The research results showed high efficiency of microplastic extraction and recovery with the range from 76% to 97%. Microplastic concentration obtained in all mussel samples variates from 1.0 ± 0.1 particles/g to 1.7 ± 0.6 particles/g, in which fiber microplastics predominated. Microplastics in mussel samples have small sizes of < 1,000 µm and 1,000–2,000 µm, make up 74.15–82.32% and 9.76–14.71%, respectively. Purple was dominant among all mussel samples. This study proved that using KOH 10% solution and KI 50% solution to isolate microplastics is a suitable approach and can be used in monitoring studies of microplastic pollution in bivalves.
Comparative Analysis of Immunization and Immunization Coverage in Children of Russian Federation Federal Districts
Authors: Grinchik Polina R. , Namazova-Baranova Leyla S. , Fedoseenko Marina V. , Girina Asiya A. , Kovalev Sergey V. , Mazokha Anastasia V. , Makushina Elena D. , Malinina Elena I. , Musikhina Anastasia Yu. , Perminova Olga A. , Plenskovskaya Nina Y. , Privalova Tatiana E. , Rtishchev Aleksei Yu. , Rusinova Dina S. , Rychkova Olga A. , Semerikov Vladislav V. , Fominykh Maria V. , Fugol Denis S. , Yakimova Nadezhda V.
Published: December 2021

Background. One of the effective ways to maintain the epidemic well-being of vaccine preventable diseases is to estimate immunization rates and coverage.

Objective. The aim of the study is to conduct comparative analysis of immunization levels among children in various regions of Russian Federation. Methods. Children aged from 6 months to 15 years conducted comparative analysis of indicators of documented immunization and immunization coverage according to forms 112/y and 036/y in four federal districts of Russian Federation. The immunization rate was estimated in individuals who had completed vaccination scheme according to the national immunization schedule (NIS) (of 2014). Immunization coverage was estimated by number of persons with at least one vaccination in past medical history.

Results. The analysis was performed on 2687 children medical records from the Central, Ural, Siberian and Volga federal districts (FD). BCG immunization rates in all FDs tend to be 100%. There are high levels of immunization against hepatitis B, as well as against measles, rubella and parotitis (the lowest values are noted in the Central Federal District: against hepatitis B — 74%, against measles, rubella, mumps — 69%, high — in the Volga Federal District: against hepatitis B — 95%, against measles, rubella, mumps — 97%). There is significant mismatch in immunization rates and immunization coverage for pertussis, diphtheria, tetanus and poliomyelitis in all FDs (from 20% to 40%) indicating that there are disturbances in vaccination schemes. Low immunization rates are noted against pneumococcal infection (from 12% in the Siberian Federal District to 36% in the Volga Federal District) and influenza (from 0.5% in the Volga Federal District to 9% in the Ural Federal District).

Conclusion. The highest immunization rates for all infections included in the NIS (apart from influenza) were revealed in the Volga Federal District. Influenza immunization rate is critically low in all FDs.
Short-Term Safety and Efficacy of Onasemnogene Abeparvovec in 10 Patients with Spinal Muscular Atrophy: Cohort Study
Authors: Nevmerzhitskaya Kristina S. , Sapego Elena Yu. , Morozova Daria A.
Published: December 2021

Background. The efficacy and safety of onasemnogene abeparvovec have been demonstrated in patients with spinal muscular atrophy (SMA) in several clinical and observational studies. Gene replacement therapy results in Russian patients with SMA is not investigated yet.

Objective. The aim of the study is to study the safety and efficacy of onasemnogene abeparvovec in children with SMA in real clinical practice.

Methods. The study included patients with proximal 5q SMA administered with onasemnogene abeparvovec. Diagnosis was verified by biallelic deletion in the 7th exon of the SMN1 gene. Gene replacement therapy was administered according to the decision of neurologists consensus in case of the absence of antibodies to the adeno-associated serotype 9 virus. The therapy safety was estimated via clinical and laboratory data from the hospital (at least 7 days) and from outpatient departments (at least 60 days). Efficacy was estimated via CHOP INTEND scale and mastering new motor skills ≥ 6 months after therapy onset.

Results. Treatment outcomes were studied in 10 SMA patients aged 19 months (15; 21). All patients developed at least one clinical manifestation (hyperthermia, vomiting, lethargy and/or loose stool) associated with drug administration during the first week of follow-up. Increased hepatic transaminases activity and monocytosis was recorded in all patients, thrombocytopenia — in 9, neutropenia — in 5, increased troponin I concentration — in 3. In three cases it was necessary to increase the oral prednisolone dose of to 2 mg/kg, in one case — the dexamethasone pulse therapy dose. The therapy efficacy was monitored ≥ 6 months after therapy onset via the CHOP INTEND scale in 2 patients (scores increased by 32 and 19 points, respectively), and via mastering new motor skills in 8 patients (positive dynamics was noted in 7 cases).

Conclusion. The onasemnogene abeparvovec is relatively safe and quite effective for using in real clinical practice
Infected Epidermoid Cyst Including Multiple Nails at the Amputated Thumb Stump: A Case Report
Authors: Kim Dae-Geun , Kwack Byung Hoon
Published: December 2021

Fingertip amputation is a common injury among trauma occurring in the upper extremity. After amputation of the fingertip, there are several treatment options according to the degree of damage. Also, the skin flap is sometimes performed when skin defects are accompanied. Among the complications associated with fingertip injury, cyst formation at the amputation stump is rare but some cases have been reported based on the pathologic findings. There was a case of an infected epidermal inclusion cyst containing multiple nail plates at the amputation stump of the thumb, so we would like to report it with a review of the literature.
Torsion of a Wandering Spleen Treated by Laparoscopic Surgery: A Case Report
Authors: Cho In
Published: December 2021

The spleen is an organ located in the upper left portion of the abdomen. Wandering spleen is defined as the location of the spleen is the shift to other parts of the abdomen rather than the left upper quadrant. Wandering spleen is a rare clinical condition and can lead to hilar torsion and subsequent infarction requiring emergency surgery. The author presents a case of torsion of a wandering spleen in a 34-year-old female presenting with abdominal pain. The patients underwent emergent laparoscopic splenectomy. She had an uncomplicated postoperative course and recovered well.
Dynamics of Human Capital in Asian Russia in the First Decades of the 21st Century
Authors:   Institute of Economics and Industrial Engineering of the Siberian Branch of RAS, Kryukov V.A. , Baranov A.O. ,   Institute of Economics and Industrial Engineering of the Siberian Branch of RAS,   Novosibirsk State University, Slepenkova I. M. ,   Institute of Economics and Industrial Engineering of the Siberian Branch of RAS,   Novosibirsk State University
Published: December 2021

Russian regions are known to be economically different. While economic inequality is quite natural for a large country, it can lead to depopulation of less developed regions. Thus, the scale of this phenomenon should be assessed and taken into account in development programmes of the Eastern regions of Russia. The study aims to examine population dynamics and migration processes occurring in Asian Russia in the first decades of the 21st century, focusing on the role of human capital at different stages of regional economic development. Migration losses and gains of Asian Russia were estimated based on information on internal migration of the population by education level and the author’s approach to assessing the accumulated human capital. The calculations confirm a hypothesis that losses from the population outflow in the studied region exceed its gains from the inflow, negatively influencing the possibilities of accelerated economic growth. The conducted research presents new results concerning the outflow of human capital from Asian Russia in the period after 2008. Considering foreign experience in reducing negative effects that have also been recently observed in the region, it is proposed to intensify efforts in three major areas: new knowledge as a factor of spatial connectivity; consolidation of the population; implementation and support of economic activity in Asian Russia. The calculation results can be used in development programmes of the Eastern regions of Russia.