bluuebunny/crossref_metadata_2025 huggingface dataset:
The Philosophy of Probability Values Behaviour, through Fractions and Composite Probability Function in the Continuous Case
Authors: Jughaiman Abdulaziz
Published: February 2024

This paper deals with probability theory, and it is an extension to a published paper that has the same title, but for the discrete case. This present paper is aiming to study probability values behavior, in the case of continuous sample space, through fractions intervals and composite function. This aim tends to study the value behavior rather than finding the value itself. Also, this aim requires usage of some concepts of continuity, geometric probability, and measure theory, which also need a brief treatment. This paper is mainly using an experiment with a design that helps to study the probability fractions values in the form of intervals in the case of one direction movement and in the case of different directions. As a result, every case reflects some aspects of probability values behavior and can clarify many important characteristics of the probability theory. In addition to applying the composite function by some important theorems of conditional probability. These are besides a proven proposition that helps to design experiment, upon the understanding of the case nature. In addition to a corollary that allows to visualize negative probability values, as a particular case (trial), that upon the validity of the explanation of negativity which should be consistent with the probability axioms.
Plafonnement des Carrières Académiques au Maroc : Analyse Approfondie par les Equations Structurelles
Authors: Taoussi Ghita , Maghni Ahmed
Published: February 2024

Cet article vise à contribuer à la compréhension du plafonnement des carrières dans le contexte universitaire, en identifiant ses différentes composantes, facteurs influents et conséquences, en donnant la parole aux enseignants chercheurs dans les universités publiques au Maroc. Pour ce faire, nous avons adopté une approche de recherche hybride, combinant des méthodes inductives et déductives, ainsi que des approches qualitatives et quantitatives. En plus de mener une étude qualitative exploratoire auprès de 18 enseignants-chercheurs et six acteurs institutionnels, dont les résultats ont déjà été publiés partiellement (Maghni & Taoussi, 2018 et 2023), nous avons également réalisé une enquête extensive en utilisant un questionnaire auprès de 117 universitaires. Ce questionnaire a été administré en ligne via un formulaire HTML envoyé aux participants. Les échelles de mesure ont été évaluées en termes de fiabilité et de cohérence interne, puis soumises à une analyse factorielle sous SPSS. La méthode PLS a été employée pour valider le modèle interne, évaluer l'adéquation du modèle externe et tester les hypothèses formulées. Les résultats mettent en évidence la diversité des perceptions des professeurs universitaires au Maroc concernant le plafonnement des carrières, en identifiant des facteurs individuels, organisationnels et contextuels qui ont été validés, ainsi que l'impact du plafonnement des carrières académiques sur l’engagement affectif envers l’établissement de travail, le stress au travail, l’efficacité dans l’avancement de carrière et l’auto-motivation d’évolution. This article aims to contribute to the understanding of career plateauing in the university context by identifying its various components, influential factors, and consequences, while giving a voice to university professors in public universities in Morocco. To achieve this, we adopted a hybrid research approach, combining inductive and deductive methods, as well as qualitative and quantitative approaches. In addition to conducting an exploratory qualitative study with 18 university professors and six institutional actors, the results of which have already been partially published (Taoussi & Maghni, 2023) , we also conducted an extensive survey using a questionnaire with 117 academics. This questionnaire was administered online through an HTML form sent to the participants. The measurement scales were assessed for reliability and internal consistency and then subjected to factor analysis using SPSS. The PLS method was used to validate the internal model, assess the fit of the external model, and test the formulated hypotheses. The results highlight the diversity of perceptions among university professors in Morocco regarding career plateauing, identifying individual, organizational, and contextual factors that have been validated, as well as the impact of academic career plateauing on affective commitment to the workplace, work stress, career advancement effectiveness, and self-motivation for progression.
Cholécystectomie par Célioscopie d’une Lithiase Biliaire Symptomatique chez une Jeune Femme de 33 Ans et Revue de la Littérature (Un Cas Clinique)
Authors: Youssouf Oumarou , Diallo Mamadou Sarifou , Ouimon Daniel Sylvere , Raphaï Clotaire Donatien
Published: February 2024

Introduction : La lithiase biliaire est une pathologie d’une grande fréquence ; elle est le plus souvent asymptomatique, mais peux se compliquer en impactant négativement la qualité de vie. L’ablation de la vésicule sous endoscopie est prometteuse. Nous rapportons un cas clinique pour discuter des modalités thérapeutiques à travers une revue de la littérature. Observation médicale : Nous rapportons, l’observation d’une femme de 33 ans avec antécédent d’obésité morbide. Elle nous a consulté en juin 2020 pour des vomissements post prandiaux chroniques avec altération de l’état générale. Les examens paraclinques réalisés n’ont pas révélé une cause évidente. Evacuée à la polyclinique Hammamet à Tunis le diagnostic d’une lithiase vésiculaire a été posé et une ablation sous célioscopie était réalisée avec extraction de 12 gros calculs d’aspect cholestéroliques et la pièce opératoire a trouvé un aspect histologique d’une cholécystite chronique diverticulaire en poussée aigue modéré. La patiente est totalement guérie de sa maladie. Conclusion : L’intérêt de ce travail révèle dans le cas non typique d’une lithiase vésiculaire et les examens échographiques réalisés à Bangui avec nos appareils peu performants étaient normaux. Notre plateau technique doit être renforcé par les appareils performants et du personnel qualifié très spécialisé. Introduction: Cholelithiasis is a very common pathology; it is most often asymptomatic, but can become complicated by negatively impacting quality of life. Removal of the gallbladder under endoscopy is promising. We report a clinical case to discuss therapeutic modalities through a review of the literature. Medical observation: We report the observation of a 33- year-old woman with a history of morbid obesity. She consulted us in June 2020 for chronic postprandial vomiting with deterioration in general condition. Paraclinical examinations carried out did not reveal an obvious cause. Evacuated to the Hammamet polyclinic in Tunis, the diagnosis of gallbladder lithiasis was made and ablation under laparoscopy was carried out with extraction of 12 large cholesterol-looking stones and the operating specimen found a histological appearance of chronic diverticular cholecystitis in moderate acute surge. The patient is completely cured of her illness. Conclusion: The interest of this work reveals in the non-typical case of gallbladder lithiasis and the ultrasound examinations carried out in Bangui with our poorly performing devices were normal. Our technical platform must be reinforced by high-performance devices and highly specialized qualified personnel.
Industrial Growth and Socio-Economic Impact: An Analysis of Armi's Manufacturing History in the Mongiana Industrial Village of Serre Calabria
Authors: Fiorenza Elia
Published: February 2024

The Mongiana Arms Factory in Calabria (Italy), built in 1852, constitutes a significant example of 19th century armoury. Designed by Domenico Fortunato Savino, active from 1852 to the mid-1860s, the factory produced 2000-3000 weapons annually for the bourbon army, with a peak of 7000-8000 in periods of maximum production. He introduced the «Mongiana» spring-loaded rifle, replacing the French model of 1842. After the unification of Italy, it lost relevance, being downgraded to a transformation workshop, and later closed. Today, part of the Ecomuseum of the Ironworks and Foundries of Calabria, the building has been under restoration since 2013. The Museum of the Royal Bourbon Ironworks, the result of a careful recovery process, allows for an in-depth exploration of the historical, economic, and technological role of the factory in the panorama of the steel industry of the time.
Competência digital de docentes da educação superior na adequação ao ensino remoto
Authors: Piontkewicz Regiane , Duarte Freitas Maria do Carmo , Mendes Junior Ricardo
Published: February 2024

Introdução: A adoção do ensino remoto para a continuidade das aulas presenciais durante a pandemia de COVID-19 exigiu, de forma urgente, o desenvolvimento de competências digitais da comunidade acadêmica. Objetivo: analisar a competência digital de docentes da educação superior brasileira durante o período de adequação ao ensino remoto. Método: pesquisa de levantamento com 322 professores do ensino superior brasileiro. Um questionário foi aplicado para levantar a percepção dos professores acerca do ensino remoto, bem como avaliar sua competência digital. Resultados: as competências digitais que precisam ser melhor desenvolvidas são: adoção de estratégias de gestão da informação; desenvolvimento de ferramentas para avaliações online; uso de ferramentas para gamificação e a aprendizagem colaborativa. Discussão: o desenvolvimento dessas competências digitais auxilia na solução dos problemas com o ensino remoto. Docentes que costumam fazer cursos e trocar experiências são os que possuem um maior desenvolvimento das competências digitais analisadas.
Qual a aplicabilidade do Referencial DigCompEdu para o ensino superior online? Um estudo com professores portugueses
Authors: Santos Cassio , Pedro Neuza
Published: February 2024

Introducción: Para garantir que as Instituições de Ensino Superior (IES) possam enfrentar os desafios trazidos, prioritariamente, pelas mudanças tecnológicas, é necessário que os seus docentes relevem níveis de competência digital adequados. Mas que competências digitais necessitam estes deter? E revela-se o quadro de referência europeu de competências digitais para educadores (DigCompEdu) válido para o contexto do ensino superior, em particular, na modalidade online? O presente estudo procura estabelecer resposta para estas questões. Método: A abordagem metodológica qualitativa foi adotada com a estratégia de recolha de dados por meio de entrevistas semiestruturadas com professores do ensino superior português. Os dados foram analisados com base em processos de análise de conteúdo e apresentados por meio da estatística descritiva. Participaram neste estudo 22 docentes que lecionam no ensino superior online. Objetivo: Analisar a aplicabilidade do DigCompEdu no que se refere à prática docente no contexto do ensino superior online. Resultados: Os resultados apontam que o DigCompEdu foi considerado como “aplicável” ao ensino superior online, tanto no global como na análise feita por área, variando de “muito aplicável” a “aplicável”. A análise por cada uma das 22 competências registrou resultados menos favoráveis nas competências 6.4 “Uso Responsável” e 6.5 “Resolução de Problemas Digitais”, ambas contidas na área 6. Discussão: Os resultados gerais apontam para a aplicabilidade do DigCompEdu no ensino superior online, no global e para as diferentes áreas...
TODDLER FECES MANAGEMENT AND BASIC IMMUNIZATION ON THE INCIDENCE OF DIARRHEA: A SPATIAL ANALYSIS
Authors: Rahmawati Nur Anisah , Mahmudah Mahmudah , Wibowo Arief , Indriani Diah , Rosita Dewi Erni , Firmanty Mustofa Vina
Published: February 2024

Background: Diarrhea is one of the leading causes of child morbidity and mortality in low and middle-income countries. 23.8% prevalence of diarrhea was found among children under five years of age. Area-based management is required to address and provide specific interventions. Purpose: The study aims to analyze the effect of unsafe toddler feces management and incomplete primary immunization on the incidence of diarrhea using a spatial analysis in East Java, Indonesia. Methods: The data used is the 2018 Basic Health Research data. The measurement of the relationship between region and diarrhea was carried out by studying Moran's I index. Lisa Cluster Map and the Lisa Significance Map were also studied to understand distribution and significance. The regression used is OLS regression, spatial lag, and spatial error. The best model is assessed by comparing various parameters. Data were analyzed using GeoDA. Results: Moran's I result shows an index value of 0.489 with a pseudo-value of 0.001 (p <0.05) and a z-value of 3.7515. Lisa Cluster Map shows seven high-high category areas, five low-low category areas, and one high-low category area. Lisa's Significance Map shows six areas p=0.05, three areas p=0.01, and four areas p=0.001. The unsafe management of toddler feces and incomplete primary immunization related to diarrhea shows a significance of p<0.05. By comparing the R square, log-likelihood, p(sign), and sigma square values, the better model is the spatial lag model. Conclusion: The unsafe toddler feces management and incomplete primary immunization related to diarrhea.
PARENTAL INTERACTIONS AND CYBERBULLYING ON PSYCHOLOGICAL IMPACT OF HIGH SCHOOL ADOLESCENTS IN SUMBERSARI DISTRICT, JEMBER
Authors: Alkatiri Shalsabiila , Rukmini Devy Shrimarti , Ubaidillah Nanda Iskandar
Published: February 2024

Background: The National Survey stated 45% of 2,777 Indonesian youths had experienced cyberbullying, including harassment via chat applications (45%), distribution of personal documentation (41%) and other harassment (14%). A preliminary study in Jember Regency stated that 21 out of 30 students had been victims of cyberbullying. Purpose: To find out the correlation between parental interaction (the role of monitoring online activity, disciplining and potential conflict) and exposure to cyberbullying (flamming, harassment, denigrations, impersonations, outing, exclusion, cyberstalking) on psychological impact (self-confidence, anxiety, hopelessness and suicidal intent) of high school youth in Sumbersari District, Jember Regency. Methods: This is a quantitative research that was conducted at 12 Senior High Schools at Sumbersari District, Jember with a total population of 5,346 students. Simple random sampling research, of 358 Lemeshow sampling students. Collecting interview data and filling out a questionnaire forJanuary 2019. Analysis of chi-square bivariate test data. Results: The significance of parental interaction was found related to conflict with the level of self-confidence and anxiety of adolescents (p 0.00; OR 2.77 and p 0.02; OR 1.71). Interestingly, it was found that harassment had an impact on the level of self-confidence (p 0.00; OR 2.29), anxiety (p 0.00; OR 1.92), hopelessness (p 0.00; ­­OR 2.91) and intention to commit suicide (p 0.02; OR 1.84). Cyberstalking had an impact on the level of self-confidence (p 0.00; OR: 3.02), anxiety (p 0.00; OR: 1.81), hopelessness (p 0.00; OR: 5.50) and intention to suicide (p 0.00; OR: 2.44). Conclusion: Parental interactions and exposure to cyberbullying have a significant effect and play an important role in the psychological impact experienced in adolescence.
DETERMINANTS OF HYPERTENSION PREVENTION BEHAVIOR IN WOMEN OF REPRODUCTIVE AGE (WRA) IN TAKERAN SUB-DISTRICT, MAGETAN REGENCY
Authors: Septiana Mia , Kusumawati Yuli
Published: February 2024

Background: Basic health research data (Riskesdas) in 2018 shows that hypertension is one of the highest causes of death in Indonesia, reaching 6.8%. If hypertension occurs in women of childbearing age, the risk of complications, morbidity, and even death will be higher due to the risk of eclampsia during labor. Efforts to prevent hypertension in women of Reproductive age (WRA) need to be improved through increasing hypertension prevention behavior. Various factors can influence hypertension prevention behavior. Purpose: This study aims to analyze the determinants of hypertension prevention behavior in a group of women of reproductive age in Takeran District, Magetan Regency. Methods: This observational study was conducted with a cross-sectional design. The research sample was women of Reproductive age in the Takeran District, Magetan Regency, with as many as 276 people. The sampling technique used purposive sampling technique. This research was conducted in March 2022, using data analysis using the Chi-Square Test and Logistic Regression Test. The instruments used in this research were questionnaires and informed consent. Results: There was a relationship between knowledge (p = 0.02), self-efficacy (p = 0.00, family support (p = 0.00, and support from health workers (p = 0.000) with hypertension prevention behavior, but there was no relationship between age (p = 1,00) and attitude (p = 0.49) with hypertension prevention behavior. Conclusion: The strongest determinant factor for hypertension prevention behavior in the group of women of Reproductive age was self-efficacy. Good self-efficacy can influence good hypertension prevention behavior.
THE DETERMINANTS OF REPRODUCTIVE HEALTH CARE BEHAVIOR IN ADOLESCENT: A CROSS-SECTIONAL STUDY
Authors: Manurung Imelda Februati Ester , Takaeb Afrona E. Lelan , Cruz Jermias da
Published: February 2024

Background: The quality of reproductive health during adolescence determines the quality of reproductive health in adulthood. The 2018 National Socioeconomic Survey found that 11% of adolescents were married before the age of 18, and 0.56% were married before the age of 15. Adolescent reproductive health issues continue to increase every year. Purpose: The study aims to analyze the determinants of reproductive health care (RHC) behavior in adolescents. Methods: This study is an analytic observational research using a cross-sectional design. The research was conducted at SMPN 20 Kupang City in 2022. The sample size are 82 students selected using a random sampling technique. The research variables are the characteristics of respondents, health literacy, parental support, teacher support, perceived vulnerability, seriousness, benefits, barriers, cue to act and RHC behavior. Bivariate data analysis used chi-square, and multivariate data analysis used logistic binary regression. Results: The results show that 57% of the respondents have a deficient reproductive health care behavior. The most dominant variable influencing RHC behavior was living with parents (PR= 4.86; CI= 1.22-19.27). Adolescents who live with their parents are 4.86 times more likely to do RHC compared to adolescents who do not live with their parents. Conclusion: These findings recommend the importance of optimizing the role of parents as peers in providing RHC education for adolescents. Parents who do not live with their children have to pay attention and remind their children to keep doing RHC.
EFFECTIVENESS OF THE LARVACIDE ETHANOL EXTRACT OF SOURSOP (Annona muricata L.) LEAVES AGAINST Aedes aegypti LARVA
Authors: Selvi Marcellia  , Tiara Inggrit Margareta  , Agustina Retnaningsih
Published: February 2024

Highlights

Dengue fever, caused by mosquitoes known as Aedes aegypti, can be avoided by applying larvicides while the insects are still in their larval stage.
The extract from soursop leaves at a concentration of 3% is the most effective for Aedes aegypti larvae, resulting in 100% mortality.

 
Abstract
Background: Dengue Hemorrhagic Fever (DHF) is an infectious disease caused by one of the four serotypes of dengue virus transmitted through mosquitoes, especially Aedes aegypti and Aedes albopictus. As the Aedes aegypti mosquito-borne DHF illness is still in its larval stage, it can be prevented by utilizing larvicides. A more secure and efficient method to eliminate mosquitoes is by using natural larvicides. Underutilized soursop leaves contain secondary metabolite components that can potentially be larvicides, such as annonins, saponins, flavonoids, and tannins. Objective: This study was to determine the effectiveness of soursop leaf extract as a larvicide in controlling Aedes aegypti vectors and to determine the most effective concentration of soursop leaf extract as an Aedes aegypti larvicide. Material and Method: The study was an analytic observational study utilizing a cross-sectional methodology. This study was carried out from March to May 2022. Soursop leaves were extracted using the percolation method, employing a solvent of 96% ethanol with alkaloids, flavonoids, saponins, and tannins. Results: The soursop leaves extract yielded in this study was as much as 131.22 grams (13.12%). The most effective concentration of soursop (Annona muricata L.) leaves was 3%, with a mortality value of 100%, not much different from the value resulting from 1% temephos. The LC50 results obtained a value of 0.163%. Conclusion: Soursop leaf extract was effective as a larvicide against Aedes aegypti mosquito larvae.
Metallic Ratios and Angles of a Real Argument
Authors: Łukaszyk Szymon
Published: February 2024

We extend the concept of metallic ratios to the real argument n considered as a dimension by analytic continuation showing that they are defined by an argument of a normalized complex number, and for rational n ≠ {0, ±2}, they are defined by Pythagorean triples. We further extend the concept of metallic ratios to metallic angles.
Green Synthesis of Cocos nucifera-Based Nanomaterials and Mechanistic Basis of Their Antimicrobial Action.
Authors: Yajeh Tanka Zuriatou , Ankoro Naphtali Odogu , Ngouana Vincent , Tchinda Taghu Franklin Loïc , Mforbesi Abongta Lum , Nguena-Dongue Branly-nathalien , Nsami Ndi Julius , Pone Kamdem Boniface , Keilah Lunga Paul , Fekam Boyom Fabrice
Published: February 2024

Caused by pathogenic microorganisms, such as bacteria, parasites, fungi, among others, infectious diseases can spread directly or from one individual to another. According to the World Health Organization, these diseases are known to cause high mortality rates, severe burdens of disability and serious worldwide aftermaths. The inappropriate use of antibiotics in humans are the main origins of the development of drug-resistant pathogens, which reduce the efficacy of these therapies, thus accentuating the need to search for effective antimicrobials. Medicinal plants have served as starting material for the preparation of a number of antimicrobial agents. To this end, the present study highlights the green synthesis of Cocos nucifera-based nanomaterials and evaluation of the mechanistic basis of their antimicrobial action. Accordingly, Cocos nucifera extract was used to reduce different concentrations (5, 10 and 20 mM) of silver nitrate solution to afford silver nanoparticles (AgNPs). These entities were further incorporated onto activated carbons (obtained by chemical activation using sulphuric acid as activation agent) to generate the nanocomposites. The antimicrobial activity of the as-prepared nanomaterials was evaluated using the broth microdilution method, while, the antioxidant activity was assessed through standard methods, such as 2,2-diphenyl-1-picrylhydrazyl (DPPH), and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) assays. Cytotoxicity of potent nanomaterials was assessed on Vero cells by spectrophotometric method. As a result, nanoparticles were successfully synthesized as evidenced by the color change of the solution from transparent to dark brown. Further characterization was carried out by UV-visible spectroscopy that showed an intense absorption spectrum at 433 nm. Fourier Transform Infrared Spectroscopy (FTIR) revealed the functional group moieties involved as a capping and reducing agent in the synthesis of AgNPs. The incubation of nanomaterials with selected bacterial and fungal strains led to significant inhibitory effects of these pathogens with minimum inhibitory concentrations ranging from 7.813 to 250 μg/ml. In antioxidant assays, the nanocomposites presented scavenging activities comparable to that of ascorbic acid. Cytotoxicity experiment revealed no toxic effects on the human mammalian cells Vero (range of selectivity indices: from >4 to >128). These results provide evidence of the implication of Cocos nucifera-based nanomaterials in targeting bacterial or fungal systems that mediate free-radical damage or by inhibiting the oxidative damage caused by selected bacteria and fungi, the most susceptible being Escherichia coli and Candida albicans, respectively.
On the Trio Unification of Information Geometry, Einsteinian Relativity, and Transient Queues the Parthasarathian Case
Authors: A Mageed Ismail
Published: February 2024

The current study characterizes the transient M/M/1 queue manifold info-geometrically, through devising Fisher Information matrix(FIM) and its inverse(IFIM). Additionally, the impact of stability on the existence of IFIM and explore the geodesic equations of motion has been revealed. More potentially, the paper discusses the relationship between stability and the Gaussian curvature, as well as the connections between queueing theory, information geometry, , Riemannian geometry, and the Theory of Relativity.
Development and Evaluation of a Dry Emulsion of Ostrich Oil as a Dietary Supplement
Authors: Ponphaiboon Juthaporn , Limmatvapirat Sontaya , Limmatvapirat Chutima
Published: February 2024

This study aimed to develop a high-quality dry emulsion incorporating omega-3, 6, and 9 fatty acid-rich ostrich oil for use as a dietary supplement. Extracted from abdominal adipose tissues using a low-temperature wet rendering method, the ostrich oil exhibited antioxidant properties, favorable physicochemical properties, microbial counts, heavy metal levels, and fatty acid compositions, positioning it as a suitable candidate for an oil-in-water emulsion and subsequent formulation as a dry emulsion. Lecithin was employed as the emulsifier due to its safety and health benefits. The resulting emulsion, comprising 10% w/w lecithin and 10% w/w ostrich oil, was stable, with a droplet size of 3.93 ± 0.11 μm. This liquid emulsion underwent transformation into a dry emulsion to preserve the physicochemical stability of ostrich oil, utilizing Avicel® PH-101 or Aerosil® 200 through a granulation process. Although Aerosil® 200 exhibited superior adsorption, Avicel® PH-101 granules surpassed it in releasing the ostrich oil emulsion. Consequently, Avicel® PH-101 was selected as the preferred adsorbent for formulating the ostrich oil dry emulsion. The dry emulsion, encapsulated with a disintegration time of 3.11 ± 0.14 min for ease of swallowing, maintained microbial loads and heavy metal contents within acceptable limits. Presented as granules containing butylated hydroxytoluene, the dry emulsion showcased robust temperature stability, suggesting the potential incorporation of animal fat into dry emulsions as a promising dietary supplement.
Performance Evaluation and Optimization of Existing Water Supply Distribution System Using WATERGEMS: Case of Sekota Town
Authors: Kassahun Demelash yenesew , Dargie Teshale
Published: February 2024

Everyone should therefore consistently get access to enough and safe water. The operation of the existing distribution network as well as the proper optimization and implementation of the new distribution systems are required for a sufficient and safe water supply. In Sekota town sufficient amount of water was not reached to the beneficiaries due to shortage of water at the source. The primary goal of this study was to evaluate the performance and optimize the existing Sekota water supply distribution system using Bentley Water GEMS.The system's hydraulic modeling is carried out by considering as a continuous supply system, and the evaluation procedure used the extended period simulation approach after calibration was done. Calibration is used to ensure the performance of the model using the observed pressure values. The output of the existing system shows pressure is very high means above the maximum pressure and velocity is very low at peak hour demand. The results of velocity and pressure before optimization have negative effect on the performance of the system. The number of pipes and junctions their velocities and pressures which were in admissible ranges are 15 and 42 pipes for velocities and zero and 59 junctions for pressure before and after optimization were evaluated respectively.
Identification of Electrostatic Hotspots at the Binding Interface of Amylin and Insulin-Degrading Enzyme: A Structural and Biophysical Investigation
Authors: Li Wei
Published: February 2024

Amylin, also known as islet amyloid polypeptide (IAPP), is a metabolic homeostasis-related hormone that is produced and released by the β cells of the pancreas, the same cells that produce insulin. Insulin-degrading enzyme (IDE) is a protease enzyme that plays an essential role in the breakdown and degradation of various peptides, including insulin and amylin. Direct binding & interaction between amylin and IDE is inextricably linked to the degradation of amylin, and research and development effort in this area is crucial to understand the potential therapeutic implications of disrupting the IDE-amylin interaction in the context of conditions where metabolic homeostasis needs to be regulated, such as diabetes and obesity. Here, this article incorporates currently available experimental complex structure of amylin and IDE, and delves deep into the interstructural biophysics underlying the binding interface of the two interacting partners. With a set of comprehensive structural biophysical analysis, this article identified an intriguing region of high electrostatic potential indicative of strong binding sites between the first N-terminal lysine (Lys1, K1) residue of amylin and Glu341 (E341) of IDE. This unique electrostatic hotspot presented herein paves the way for the rational design of drug-like small molecules that can selectively disrupt this interaction, offering a targeted therapeutic strategy for improved metabolic homeostasis, particularly for patients with diabetes and obesity.
MkRP: Multiple k Registry Placement for Fast Container Deployment on Edge Computing
Authors: SONG CHUNGGEON , YU HEONCHANG , Gil Joon-Min
Published: February 2024

Edge computing reduces the response time of real-time services with handling dynamic traffics reliably. Edge servers with limited resources utilize container technology that provides a lightweight execution environment. When deploying containers in edge servers, a container image is required and is downloaded from a remote registry. Therefore, these operations are dependent on network overhead between the container deployment system and the remote registry. Through motivation experiments, we show that container pooling time increases in proportion to physical distance and has characteristics that vary flexibly depending on runtime time. In this study, we define a system model for high-speed registry deployment in this edge system and propose a clustering technique into k groups based on the network overhead and affinity of the regionally distributed edge servers that make up the edge system. Also, considering idle resources, we propose a technique to deploy a registry after electing a leader for each cluster. A simulation experiment is conducted to verify the performance of the proposed technique and shows that performance improvement can be achieved regardless of the number of edge servers and the k value.
Role of Advanced Glycation End Products as New Biomarkers in Systemic Lupus Erythematosus
Authors: Carrión Barberà Irene , Triginer Laura , Tío Laura , Pérez-García Carolina , Toloba Andrea , Ribes Ana , Abad Victoria , Pros Ana , Bermudez Marcelino , Castro-Boqué Eva , Lecube Albert , Valdivielso José , Monfort Jordi , Salman-Monte Tarek Carlos
Published: February 2024

Introduction:
Advanced glycation end-products (AGEs) may play a relevant role as inducers in the chronic inflammatory pathway present in immune-mediated diseases, such as systemic lupus erythematosus (SLE). AGEs concentrations have been associated, with discrepant results to date, with some parameters such as disease activity or accrual damage, suggesting their potential usefulness as biomarkers of the disease.
Objectives:
To confirm differences in AGEs levels measured by cutaneous autofluorescence between SLE patients and healthy controls (HC) and study their correlation with various disease parameters.
Methods:
Cross-sectional study, where AGEs levels were measured by skin autofluorescence, and SLE patients’ data were compared with those of sex- and age-matched HC in a 1:3 proportion through a multiple linear regression model. Correlations of AGEs levels with demographic and clinical data were analyzed through ANOVA tests. Both analyses were adjusted for confounders.
Results:
AGEs levels in SLE patients were significantly higher than in HC (p<0.001). We found statistically significant positive correlation with SLE disease activity index (SLEDAI) and damage index (SDI), physician and patient global assessment, C-reactive protein, leukocyturia, complement C4, IL6 and oral ulcers. We also found a negative statistically significant correlation with current positivity of anti-nuclear and anti-Ro60 antibodies.
Conclusions:
AGEs seem to have a role in LES pathophysiology, becoming a new management and prognosis biomarker in this disease. The association with specific antibodies and disease manifestations may indicate a specific clinical phenotype related to higher AGEs levels.
Advancing Sustainable Development: Broad Applications of Passive Radiative Cooling
Authors: Liang Lin , Bai Shengxi , Lin Kaixin , Kwok Chui Ting , Chen Siru , Zhu Yihao , Tso Chi Yan
Published: February 2024

With the increasing demand for energy worldwide, researchers from different fields have been striving to improve the sustainability and proper utilization of energy resources. Passive radiative cooling, as a natural energy transport method, can achieve cooling without additional external energy input. This review provides a comprehensive examination of passive radiative cooling, including its fundamental theories and latest development. A particular emphasis is placed on the diverse range of fields where passive radiative cooling has been applied, notably including but not limited to construction and architecture. The current state of applications, potential challenges that may arise with wider adaption and promising research directions for each field are thoroughly discussed. This review underscores the universal applicability and feasibility of passive radiative cooling and contributes to its future development by identifying promising areas for further exploration.
Models of Protocells Undergoing Asymmetrical Division
Authors: Villani Marco , Alboresi Elena , Serra Roberto
Published: February 2024

The conditions which allow sustained growth of a protocell population are investigated in the case of asymmetrical division. The results are compared to those of previous studies concerning models of symmetrical division, where synchronization (between duplication of the genetic material and fission of the lipid container) was found under a variety of different assumptions about the kinetic equations and about the place where molecular replication takes place. Such synchronization allows a sustained proliferation of the protocell population. In the asymmetrical case there can be no true synchronization, since the time to duplication may depend upon the initial size, but we introduce a notion of homogeneous growth which actually allows sustained reproduction of a population of protocells. We first analyze Surface Reaction Models, defined in the text, and we show that in many cases they undergo homogeneous growth under the same kinetic laws which lead to synchronization in the symmetrical case. This is the case also for Internal Reaction Models (IRMs), which however require a deeper understanding of what homogeneous growth actually means, as discussed below.
Factors Associated with Non-Adherence to Tuberculosis Pre-ventive Treatment among Adult Contacts of Pulmonary Tuberculosis Cases with Latent Tuberculosis Infection in Catalonia, Spain, in 2019−2021
Authors: Plans-Rubió Pere , Godoy Sofia , Toledo Diana , Domínguez Angela , Caylà Joan , Parron Ignasi , Millet Joan Pau , Godoy Pere
Published: February 2024

The aim of the study was to identify factors associated with non-adherence to tuberculosis (TB) preventive treatment among contacts with latent TB infection of new cases of pulmonary TB cases reported in Catalonia in 2019-2021. All contacts aged 18 years or older with a latent TB infection who received a TB preventive treatment were included in the study. The Chi square test and the odds ratios (OR) were used to assess the association between non-adherence to TB preventive treatment and the study variables, considering a p < 0.05 as statistically significant. Multiple logistic regression analysis was used to detect the in-dependent factors associated with TB preventive treatment non-adherence, considering a p < 0.05 as statistically significant. The percentage of non-adherence to TB preventive treatment found in this study was 23.7%. A multivariable logistic regression analysis determined that the following factors were significantly associated with TB preventive treatment non-adherence among adult contacts: “exposure at school or workplace” (aOR = 3.34), “exposure to an index case without laboratory confirmation of TB” (aOR = 2.07), “immigrant contact” (aOR = 1.81), “male gender” (aOR = 1.75) and “exposure duration <6 hours per week or sporadic exposure” (aOR = 1.60). By contrast, the factor “short-term TB preventive treatment regimen” (aOR = 0.38) was significantly associated with a lower treatment non-adherence. Adherence to TB preventive treatment should be improved among adult contacts of TB pulmonary cases with latent TB infection by recommending short-term treatment regimens and by developing health education activities, with a greater focus on contacts with factors associated with treatment non-adherence.
OVERVIEW OF UNDERSTANDING AND PREPAREDNESS FOR EARTHQUAKES IN THE PERSPECTIVE OF VOCATIONAL HIGH SCHOOL STUDENTS
Authors: Novyanti Yuwita , Rahmayanti Henita , Widiasanti Irika
Published: February 2024

Knowledge of disaster mitigation is the most essential component and a key factor for preparedness. The possessed knowledge typically influences attitudes and concerns, fostering readiness to anticipate disasters. Vocational High School students should be informed about the various disasters that frequently occur in their areas, as well as the procedures to face sudden disasters. The significant loss of lives and various damages to buildings and facilities in the vicinity underscore the need for a deeper examination of mitigation efforts. The objective of this study is to assess the level of understanding and preparedness of Vocational High School students regarding earthquake natural disasters. The research method employed is quantitative, with descriptive statistics as the analytical technique. The instruments used include test instruments and non-test instruments utilizing Google Forms to collect data from several Vocational High Schools in various cities in DKI Jakarta, Sukabumi, and Tangerang. The research findings reveal that 42% of students are unaware of earthquake disaster mitigation measures. Additionally, 69% of students lack knowledge about minimizing damage from earthquakes in terms of building construction. Furthermore, 65% of students are unfamiliar with images related to earthquake-resistant construction. Moreover, 52% of students still do not know the local earthquake resilience features of earthquake-resistant houses. Lastly, 52% exhibit a panicky attitude, hastily evacuating buildings during an earthquake. The conclusion drawn from this research is that the knowledge of Vocational High School students regarding earthquake disasters and their mitigation measures is still low.
Siar Abdi Kala Pandemi
Authors: Astuti Cindy Cahyaning
Published: February 2024

Segala puji dan syukur kehadirat Allah SWT yang telah melimpahkan rahmat, karunia, dan hidayah-Nya, sehingga penulis dapat menyelesaikan laporan KKN Tangguh 2010, yang berjudul “Siar Abdi Kala Pandemi” Kisah Pengabdian Masyarakat Mahasiswa Universitas Muhammadiyah Sidoarjo. Adapun tujuan dari penulisan ini adalah untuk memenuhi syarat ke jenjang Sarjana. Kegiatan KKN Tangguh ini juga bertujuan untuk menambah wawasan masyarakat tentang “ Protokol Kesehatan dan Pendampingan Pembelajaran Pendidikan di Era Pandemi Covid-19”. Kuliah Kerja Nyata (KKN) adalah program yang ditempuh mahasiswa Universitas Muhammadiyah Sidoarjo merupakan perwujudan dari salah satu Catur Dharma Perguruan Tinggi, yaitu bermaksud memberikan pengalaman secara langsung baik fisik maupun mental kepada calon sarjana dengan terjun bersama masyarakat dengan menerapkan ilmu jurusan masing-masing. Didalam KKN-Tangguh 2020 Universitas Muhammadiyah Sidoarjo, lokasi kegiatan tersebar di berbagai wilayah yakni di masing- masing desa mahasiswa.
Análisis metodológico de las Guías de práctica clínica de Cirugía bariátrica: a scoping review
Authors:   , Flores Hartley Bryan Eduardo , Arista Villanueva Kassandra Marjori
Published: February 2024

Antecedentes y Objetivos: La incidencia de la obesidad está en aumento, lo que representa un importante desafío para la salud pública. Con la aparición de nuevas estrategias de tratamiento quirúrgico, las guías de práctica clínica (GPC) de alta calidad son esenciales para mejorar la atención de la obesidad. Este estudio evaluó las características de estas GPC, incluido su alcance, los métodos utilizados para generar recomendaciones y las calificaciones otorgadas. Métodos: Se realizó un Scoping Review de GPC que proporcionaban recomendaciones sobre el manejo preintra-postoperatorio de la cirugía bariátrica en pacientes mayores de 18 años, publicadas entre 2018 y 2022 en importantes organizaciones y bases de datos recolectoras de directrices. Se utilizó la herramienta “Appraisal of Guidelines Research and Evaluation” (AGREE) II para evaluar la calidad de las recomendaciones y el sistema utilizado para elaborarlas. Se redactó un protocolo siguiendo las pautas del "Preferred Reporting Items for Systematic Reviews and Meta-analysis" (PRISMA) Protocols y la "Guía para realizar revisiones sistemáticas de alcance" del Joanna Briggs Institute. Resultados: Se identificaron nueve GPC. Según la herramienta AGREE II, aproximadamente el 50% de las GPC obtuvieron un rigor metodológico adecuado. Cinco estudios utilizaron el sistema GRADE para asignar niveles de evidencia a las recomendaciones, y tres guías cumplieron con los requisitos mínimos sugeridos por el GTG. La mayoría de las GPC recomiendan la cirugía bariátrica para pacientes con un índice de masa corporal (IMC) ≥40 kg/m2, resaltando la importancia de enfoques quirúrgicos individualizados basados en las necesidades del paciente y las opiniones de expertos. Conclusiones: La mayoría de las GPC para la cirugía bariátrica tienen una calidad metodológica cuestionable. Solo tres GPC utilizaron los marcos GRADE EtD para elaborar sus recomendaciones, y una de ellas detalló completamente el proceso de desarrollo de la guía…
Estudio bibliométrico: Covid-19 y enfermedad cardiovascular
Authors:   , Espinoza Alva Valery Gineth , Sanchez Garcia Johan Manuel
Published: February 2024

Antecedentes y objetivos: En diciembre de 2019, en la ciudad de Wuhan, provincia de Hubei, China se reportó el brote de una nueva enfermedad respiratoria. La cual causa el síndrome respiratorio agudo severo, tiene como agente patológico a un nuevo coronavirus, identificado como SARS-CoV-2. Se encontró gran mortalidad en población con factores de riesgo cardiovascular y enfermedades preexistentes que agravaron la evolución clínica y el riesgo de mortalidad. Múltiples investigaciones se dirigieron al análisis de la relación de ambas enfermedades. Por tal motivo el objetivo de este trabajo fue describir las características bibliométricas de las publicaciones relacionadas a Covid-19 y enfermedad cardiovascular. Materiales y métodos: Este trabajo de investigación, fue un estudio descriptivo de enfoque bibliométrico, basándose en el análisis de los artículos científicos publicados sobre factores de riesgo cardiovascular y Covid-19 a través de la base de datos de SCOPUS hasta julio de 2023. Resultados: Se obtuvieron 481 artículos, los que en su mayoría fueron observacional de tipo cohorte y publicados en idioma inglés. El país que mayor producción científica tuvo fue EE.UU. La mayor cantidad de apariciones de un autor fue en 9 artículos. Menos de la mitad tuvieron financiamiento alguno. Conclusiones: Se ha observado que el interés sobre saber más acerca del tema va en aumento, por ello es necesario incentivar la publicación de más artículos relacionados al tema para fortalecer la base bibliográfica y conocer el curso de los factores de riesgo cardiovascular post Covid-19.
Liderazgo transformacional y su influencia en la rotación del personal en la empresa CGM RENTAL S.A.C. Perú 2021
Authors:   , Ruiz Carrillo Xiomara Crisell
Published: February 2024

La guía de un líder en las organizaciones es imprescindible para lograr los objetivos propuestos, es necesario contar con un líder que represente el modelo a seguir del colaborador quien en adelante puede también ocupar ese cargo, si esta idea no se desarrolla apropiadamente en el ámbito laboral, se corre el riesgo de tener altos índices de rotación de personal, lo cual genera costos excesivos a la empresa. Era preciso analizar la influencia del liderazgo transformacional sobre la rotación del personal, para ello se desarrolló una investigación no experimental, de nivel causal y enfoque cuantitativo, con una muestra de 108 colaboradores, con recogida de información a través de instrumentos de elaboración propia validados y confiables. Al analizar la hipótesis general con la Prueba del Seudo R2 de las variables se determinó que el liderazgo transformacional influye significativamente en la rotación del personal, calculado a través de la regresión logística ordinal obteniendo el 27.6% de la variabilidad de la Rotación del personal. Atribuyendo este resultado a la falta de espacios de confianza que valoren los aportes de creatividad e innovación del personal y los orienten con responsabilidad hacia el cumplimiento de objetivos empresariales.
Implementación de un aplicativo móvil para mejorar el proceso de estimación de costos de producción en cultivos transitorios de Ecovida Tahuamanu, 2022
Authors:   , Flores Vila Luis Javier , Arenas Coha Yobar Enrique
Published: February 2024

El objetivo de la presente investigación fue la implementación de un aplicativo móvil para mejorar el proceso de estimación de costos (PEC) de producción en cultivos transitorios de la Asociación Agropecuaria Ecovida, de Tahuamanu-Tahuamanu-Madre de Dios. La metodología fue de diseño pre-experimental, con un enfoque cuantitativo y de tipo aplicado. Se aplicó una encuesta en una muestra de 48 agricultores en dos momentos, una pre-prueba para conocer los tiempos de estimación actuales y una pos-prueba con el uso del aplicativo en dispositivos móviles y equipos de escritorio. La prueba de Wilcoxon aplicada en la hipótesis general y las especificas arrojo resultados significativos con Sig. < 0.001 < 0.05, por lo tanto, las hipótesis nulas fueron descartadas y las hipótesis de la investigación fueron confirmadas, lo que nos lleva a concluir que la implementación de un aplicativo móvil mejorará significativamente el PEC de producción en cultivos transitorios de Ecovida Tahuamanu, 2022 tanto a nivel general como a nivel de las etapas de preparación del terreno a cultivar, siembra, mantenimiento y cosecha del cultivo. Por su parte de la estadística descriptiva se desprende que la media general de la ejecución del proceso de forma manual (pre-test) era de 3038 minutos reduciéndose a 377 minutos en el post-test con el uso del aplicativo, es decir, se produjo una reducción del 88% en el tiempo promedio del proceso objeto de la investigación. En la discusión se presentan las limitaciones, hallazgos y recomendaciones.