bluuebunny/crossref_metadata_2025 huggingface dataset:
PRZEJMOWANIE WŁADZY PREZYDENCKIEJ W STANACH ZJEDNOCZONYCH
Authors: Kwiatkowski Wojciech
Published: September 2021

Artykuł omawia procedurę przekazywania władzy prezydenckiej w USA. Jest to złożony i wieloetapowy proces, w trakcie którego prezydent-elekt Stanów Zjednoczonych przygotowuje się do przejęcia kontroli nad administracją federalną USA od urzędującego prezydenta. Procedura ta formalnie rozpoczyna się w chwili, gdy znany jest zwycięzca listopadowych wyborów i trwa do dnia inauguracji, kiedy to prezydent-elekt składa przysięgę. W artykule omówiono zarówno kluczowe rozwiązania ustawy o przekazywaniu władzy prezydenckiej z 1963 roku (tj. weryfikacja kandydatów na stanowiska w nowej administracji, czy zasady organizowania codziennych briefingów z zakresu informacji mających znaczenie dla bezpieczeństwa narodowego USA), jak i niepisane zwyczaje panujące w tym czasie.
Uso da infometria na identificação de clusters e o diagrama multidisciplinar das pesquisas brasileiras sobre inclusão digital na área de educação
Authors: Neves Barbara Coelho
Published: September 2021

O artigo apresenta resultados de uma investigação sobre os fundamentos dos estudos desenvolvidos no Brasil sobre o tema inclusão digital na área de Educação. Apresenta o quadro das leis da bibliometria e o diagrama multidisciplinar das pesquisas sobre inclusão digital na Educação. Traz como objetivos discutir os fundamentos teóricos-conceituais do termo inclusão digital e apresentar alguns dos indicadores (clusters) levantados na pesquisa macro da qual este artigo é uma das partes complementares. O método utilizado é do tipo infométrico desenvolvido no Banco de Teses e Dissertações da CAPES. A coleta de dados foi realizada por meio do formulário infométrico e a análise dos dados a partir do teste sociométrico. Como resultado o artigo indica o quantitativo dos trabalhos científicos (teses e dissertações) sobre inclusão digital na Educação, os principais clusters quanto aos fundamentos teóricos e o diagrama multidisciplinar das pesquisas brasileiras sobre inclusão digital na Educação.
Institucionalização da infância desvalida em perspectiva comparada Lisboa/Portugal – Floriano/Piauí/Brasil (1834-1890)
Authors: Carvalho Thatianny Jasmine Castro Martins de , Holanda Patrícia Helena Carvalho
Published: September 2021

Este trabalho tem como objetivo identificar relações de causalidade, confluências e divergências entre os contextos de criação das instituições asilares; analisar estatutos, missões, orçamentos das despesas e demais fontes documentais como ofícios e relatórios que evidenciem relações de identidade e circulação de ideias sobre o tema. Para atender profundas mudanças sociais percebidas mais intensamente na segunda metade do século XIX, em diferentes contextos, foram implantadas instituições de acolhimento à infância desvalida em Portugal e, em seguida, sob influência do processo colonizador e avanço do capitalismo industrial e da globalização, também no Brasil. Esta pesquisa pretende tecer diálogos e grelhas comparativas entre instituições de acolhimento de Lisboa/Portugal e Floriano/Piauí/Brasil. Resultados parciais revelam diferenças, aproximações e a circulação de ideias sobre a infância desvalida aquém e além-mar. O estudo apoia-se em autores como Nóvoa (2009), Rizzini (1997), Newitt (2018), Venâncio (1997), entre outros.
Experiências significativas em artes visuais na educação infantil
Authors: Martins Simone Aparecida , Mattos Maria de Fatima da Silva Costa Garcia de
Published: September 2021

Este estudo investigou a relevância das experiências estéticas na formação do professor atuante na Educação Infantil, no sul do estado de Minas Gerais. Refletimos sobre a necessidade e a importância do ensino por meio de experiências estéticas significativas pautadas pela imaginação criadora, a sensibilidade, a educação do olhar, o protagonismo infantil e a relação da arte na educação como expressão vital para a criança na formação das linguagens plástica e visual. A pesquisa de abordagem qualitativa utilizou a técnica do grupo focal com oito professoras, sobre o qual os dados coletados foram analisados por meio da Análise de Conteúdo. Os resultados obtidos comprovaram o descompasso existente entre a teoria e as metodologias contemporâneas, em relação às práticas vigentes. Constatou-se que o professor necessita vivenciar experiências estéticas a fim de ampliar o olhar para além do estereótipo, e possibilitar que as crianças exercitem o potencial criativo com liberdade de expressão e imaginação.
Mediação tecnológica e processo educacional em tempos de pandemia da Covid-19
Authors: Arruda Eucidio Pimenta , Gomes Suzana dos Santos , Arruda Durcelina Ereni Pimenta
Published: September 2021

A pandemia da Covid-19 provocou no Brasil e no mundo mudanças repentinas nos campos social, político, econômico e educacional. Dentre as medidas implementadas, o isolamento social implicou no fechamento das escolas, que passaram a ser desafiadas a assumirem o ensino remoto emergencial, mediado pelas tecnologias digitais. Nesse sentido, pretendeu-se com este estudo verificar como a escola pode cumprir a sua função político-social no contexto da crise da pandemia. Quanto à metodologia, trata-se de um estudo exploratório de abordagem qualitativa que envolveu o uso de dados secundários e empíricos da Unesco e, ainda, a realização de um levantamento que mapeou a maneira como os estados no Brasil estão conduzindo as atividades escolares. Os resultados atestam que a pandemia da Covid-19 exerce impactos diferenciados na vida social e que a oferta do ensino remoto pelos estados tem sido encaminhada por meio de diferentes propostas; entretanto, verificou-se que, de modo geral, as iniciativas governamentais não têm promovido efetivamente a participação da comunidade escolar.
Relação entre a didática profissional e a engenharia didática de desenvolvimento: uma discussão para a formação de professores de matemática
Authors: Alves Francisco Regis Vieira , Cidrão Georgyana Gomes
Published: September 2021

Este trabalho tem por objetivo levar a discussão entre a Engenharia Didática de Desenvolvimento, uma importante metodologia francesa usada por quatro décadas na educação francesa advinda da Didática da Matemática, juntamente com a Didática Profissional, uma vertente francófona que constrói a aprendizagem profissional, visando construir dispositivos para a formação inicial ou continuada de professores, de interesse particular, professores de Matemática. A discussão se baseia no ponto de vista de Chevallard (2009), Pastré, Mayen e Vergnaud (2006), Pastré (2008) e Alves (2018a; 2018b; 2019; 2020). A síntese das pesquisas analisadas mostra que a Didática da Matemática e a Didática Profissional mantém uma linha tênue no que concerne à formação de professores.
A implementação do Pnaic em território vulnerável no município de São Paulo
Authors: Di Giusto Silvana Menegoto Nogueira , Ribeiro Vanda Mendes , Vóvio Claudia Lemos
Published: September 2021

Este artigo trata da implementação do Programa Pacto Nacional para Alfabetização na Idade Certa (Pnaic) na Rede Municipal de Ensino de São Paulo (RMESP), em território de vulnerabilidade social. A pesquisa empregou entrevistas entre agentes implementadores de nível macro, meso e micro, analisadas a partir de categorias advindas da literatura sobre políticas públicas. Constatou-se resistência ao Pnaic no município estudado devido às prescrições didáticas para o desenvolvimento da consciência fonológica e às situações interpretadas como descompromisso dos agentes de nível macro com o programa. Implementadores do Programa usaram de sua discricionariedade por meio de adequações nas diretrizes para lidar com tais resistências e para incluir coordenadores pedagógicos nas formações. Estratégias específicas para garantia da alfabetização nos contextos de vulnerabilidade social não foram observadas.
OIP5-AS1: A Fascinating Long Noncoding RNA in Carcinoma
Authors: Zhong Juanjuan , Chen Jinlan , Wang Bei , Zhou Zixian , Shen Yujie , Gong Yibo , Tan Fangshun , Yuan Chengfu
Published: September 2021

Background:

It is substantiated that LncRNAs are associated with carcinoma progression. OIP5-
AS1 is a tumor-related carcinoma suppressor lncRNA, previously discovered in zebrafish, which is involved in
the progression of a variety of cancers, has a regulatory effect on carcinoma, and interacts with miRNA and
other biomolecules to affect the physiological and pathological processes of carcinoma cells. This article will
discuss the effect of OIP5-AS1 in various cancers and its regulatory mechanism.

Methods:

This paper summarized and analyzed OIP5-AS1, which functions on the germination and progression
of carcinoma and its regulatory mechanism. Meanwhile, the related research was retrieved and collected
by the PubMed system.

Results:

OIP5-AS1 is overexpressed in various tumors, which regulates and controls tumor growth and participates
in tumor progression, including breast carcinoma, ovarian carcinoma, cervical carcinoma, lung carcinoma,
laryngeal squamous cell gastric carcinoma and hepatocellular carcinoma. The research evidence proves
that OIP5-AS1 takes part in carcinoma proliferation, growth, migration, invasion, and apoptosis.

Conclusion:

OIP5-AS1 probably can be an effective biomarker or a potential therapeutic target in multiple tumors.
Amalgamation and Scrutinizing of Leucine Derivatives Schiff Bases Complexes
as Antimicrobial Agent
Authors: Pervaiz Muhammad , Tahir Muhammad Bilal , Ahmad Ikram , Saeed Zohaib , Sagir Muhammad , Younas Umer , Ahmad Awais , Rashid Ayoub , Syed Quratulain , Adnan Ahmad
Published: September 2021

:

The enhanced applications of Schiff bases metal complexes of amino acid derivatives
have captured the attention of researchers for the synthesis of leucine derivatives of Schiff bases
metal complexes. Amino acids are considered to be essential part of food supplements as well as
derivatives of Schiff bases in coordination chemistry due to their donor ability. The leucine derivatives
Schiff bases ligand have been synthesized by condensation reaction between amine of leucine
with aldehyde or ketone bearing molecules attached with them. These complexes were characterized
by different spectroscopic tools in order to confirm their structural geometries. The structural
geometries are considered to be very important in order to improve the antimicrobial potential of
leucine derivative metal complexes. By taking into account the antimicrobial potential of titled
compounds, a comprehensive review of leucine derivatives of Schiff bases metal complexes has
been compiled.
Polymer-based Nanotherapeutics for Burn Wounds
Authors: Yadav Awesh , Ujjwal Rewati Raman , Tripathi Shourya , Krishna S.T.V. Sai
Published: September 2021

Burn wounds are complex and intricate injuries that have become a common cause of trauma leading to significant mortality and morbidity every year. Dressings are applied to burn wounds with the aim of promoting wound healing, preventing burn infection and restoring skin function. The dressing protects the injury and contributes to recovery of dermal and epidermal tissues. Polymer-based nanotherapeutics are increasingly being exploited as burn wound dressings. Natural polymers such as cellulose, chitin, alginate, collagen, gelatin and synthetic polymers like poly (lactic-co-glycolic acid), polycaprolactone, polyethylene glycol, and polyvinyl alcohol are being obtained as nanofibers by nanotechnological approaches like electrospinning and have shown wound healing and re-epithelialization properties. Their biocompatibility, biodegradability, sound mechanical properties and unique structures provide optimal microenvironment for cell proliferation, differentiation, and migration contributing to burn wound healing. The polymeric nanofibers mimic collagen fibers present in extracellular matrix and their high porosity and surface area to volume ratio enable increased interaction and sustained release of therapeutics at the site of thermal injury. This review is an attempt to compile all recent advances in the use of polymer-based nanotherapeutics for burn wounds. The various natural and synthetic polymers used have been discussed comprehensively and approaches being employed have been reported. With immense research effort that is currently being invested in this field and development of proper characterization and regulatory framework, future progress in burn treatment is expected to occur. Moreover, appropriate preclinical and clinical research will provide evidence for the great potential that polymer-based nanotherapeutics hold in the management of burn wounds.
Holothuria arenicola Extract Attenuated Hepatic Steatosis in Splenectomized
Rat Fed High Fat Diet
Authors: Sadek Shimaa A. , Farouk Asmaa E. , Fahmy Sohair R. , Soliman Amel M.
Published: September 2021

Background:

Non-alcoholic fatty liver disease (NAFLD) is a considerable public health
concern due to the excessive dietary consumption of high caloric diet and subsequent obesity. Additionally,
splenectomy is considered one of the major common risk factors for NAFLD.

Objective:

Regardless of the non-alcoholic fatty liver disease (NAFLD) being the most common
chronic disorder, there is no effective cure for it. Therefore, the current study aimed to investigate
the efficacy of Holothuria arenicola extract (HaE) on hepatic steatosis in splenectomized (SPX)
rats fed High fat diet (HFD).

Methods:

Male Wistar rats (n=28) were randomly assigned to four groups: sham rats fed a standard
diet, sham rats+ HFD, SPX+HFD and SPX+HFD+HaE. The estimation of hematological and
some biochemical parameters, as well as oxidative status, were analyzed.

Results:

Oral administration of HaE caused a significant amelioration in all hematological parameters
relative to untreated splenectomized rats. Concerning lipid metabolism, HaE treatment caused
a pronounced amelioration in lipid metabolism, as indicated by the decreased total cholesterol, triglycerides
and LDL-cholesterol contents, as well as the increased HDL- cholesterol level. HaE treatment
significantly enhanced hepatic function, as exhibited by the reduction in liver enzyme activities
as well as the increase in protein and albumin content. Moreover, HaE could retard the hepatic
oxidative stress via a pronounced increase in hepatic GSH content and antioxidant enzyme activities
besides decreasing MDA, NO and H2O2 formation.

Conclusion:

HaE could be utilized as a potential alternative hepatoprotective remedy via lipid
metabolism and oxidative damage attenuation.
Development of Standardized Cyanthillium cinereum (L.) H.Rob. Extract
and Determination of its Biological Activities
Authors: Kaji Mafusol , Puttarak Panupong
Published: September 2021

Aim:

The development of a suitable standardized Cyanthillium cinereum (L.) H.Rob. extract
is an active ingredient in healthcare products.

Background:

C. cinereum is the herbal tea specified in the Thai National List of Essential (herbal)
Medicines (NLEM) as the most efficacious tea for smoking cessation. However, herbal tea is inconvenient,
and no standardized C. cinereum extraction method was known.

Objectives:

The study aims to develop a standardized C. cinereum extract preparation method and
determine its biological activities.

Methods:

Various extraction and fractionation methods were performed in order to optimize a suitable
standardized extract. The extraction yield, biological activities, and biomarkers (apigenin and
luteolin) of the HPLC method were used to select the most suitable extraction method.

Results:

The results showed that the microwave-assisted extraction (MAE) method with 75%
EtOH was the most suitable method. The MAE method obtained apigenin and luteolin at
0.320±0.029 and 0.487±0.012 mg/g, respectively. MAE showed good anti-inflammatory and antioxidant
(DPPH and FRAP assay) activities. Subsequently, the MAE extract was fractionated by
the Diaion® HP-20 column in order to obtain the most suitable standardized extract. The 50% plus
75% EtOH fractions showed high apigenin (91.20±1.23 mg/g) and luteolin (167.00±0.49 mg/g)
contents and exerted potent bioactivities. The standardized C. cinereum extract presented high effectiveness
of NO inhibitory activity with an IC50 of 7.88±3.56 μg/mL, and also exerted DPPH
scavenging efficacy with an IC50 value of 8.88±0.17 μg/mL and quercetin equivalent at
137.50±2.20 mg/g by FRAP assay.

Conclusion :

This study succeeded in developing a high-yield extraction method of standardized C.
cinereum extract, with potent antioxidant and anti-inflammatory activities, suitable for various purposes.
Multifaceted Asylum Triangle: Does Fragmentation of the Right to Asylum and the Non-Refoulement Rule Deters the Functioning of Equitable and Predictable Burden- and Responsibility-Sharing Mechanism on Refugees?
Authors: Zaalishvili Tamta
Published: September 2021

The global refugee protection system is founded on two core values, assuring a safe and dignified life away from violent regimes and conflicts: the right to asylum and the non-refoulement rule. While there are no internationally agreed definitions for these concepts, their fragmentation affects the equitable and predictable burden- and responsibility-sharing, and subsequently, successful international cooperation in refugee matters. 

By analysing the right to asylum in legal theory and examining its application in the jurisprudence of international human rights monitoring bodies, this article seeks to explore the complexity of heterogeneous approaches with regard to refugees. Furthermore, the impediments to the functioning of the current refugee protection regime is identified by analysing the complicated nature of its umbrella maxim - the non-refoulement rule. The article examines how the lack of clarity on the contents of the right to asylum and the non-refoulement rule causes different, sometimes contradictory, approaches regarding the corresponding international obligations of states. It further explores how the diversified understanding of these foundational principles makes it difficult to identify common protection needs and the responsibilities of states with regard to international cooperation and burden- and responsibility-sharing on refugee matters. 

Eventually, the fragmentation of these core values threatens their unequivocal application and results in failing refugee protection regimes. Consequently, this article argues that a common understanding on the right to asylum and non-refoulement rule represents a condicio sine qua non for securing equitable and predictable burden- and responsibility-sharing mechanism in refugee matters.
International Crimes in the Digital Age: Challenges and Opportunities Shaped by Social Media
Authors: Belhadj Ali Chiraz
Published: September 2021

Due to the growing influence of social media on the dynamics of international criminal law, the investigation and prosecution of international crimes have taken an entirely new dimension. Particularly, the increasing use of these platforms has led to the rise of new types of evidence, namely user-generated evidence thus creating considerable opportunities, but also unique legal challenges. Indeed, while social media became a source of evidence for public authorities, these same platforms are used to fuel offline brutality and atrocities. This article thus provides a comprehensive insight into the advantages and disadvantages produced by the growth of user-generated evidence. It also calls for a necessary legal change to accommodate the digital age. Indeed, it is imperative to adjust the existing legal framework in order to contain the downsides of user-generated evidence on the one hand, and promote their effective use in the International Criminal Court to promote justice and transform UGE in the much needed mine of evidence.
Application of the biocenotic tree assessment method in the "Vila Mîndîc" park (Moldova) for the implementation of a conceptual land-use project – a case study
Authors: Ozimkowska Lidia , Wojtatowicz Jerzy
Published: September 2021

The article presents the aplication of the biocenotic tree assessment method in the "Vila Mîndîc" park (Moldova). While conducting the inventory, preliminary design decisions were taken into account, which also influenced the determination of tree values. By extending the plant valorisation to the study of health, including safety for humans, the results were obtained to carry out the project. Particular areas were selected, which regardless of the conditions, must ensure safe stay; parts of the area where visiting the park is restricted and those where, due to high biocenotic values (including protection of animal breeding and nesting sites) communication routes and leisure areas are not planned. On the basis of the research, areas of exceptional importance for animals were identified and a conceptual land development project was carried out to accommodate human recreational needs.
Mild Adverse Events of Sputnik V Vaccine in Russia: Social Media Content Analysis of Telegram via Deep Learning
Authors: Jarynowski Andrzej , Semenov Alexander , Kamiński Mikołaj , Belik Vitaly
Published: September 2021

Background

There is a limited amount of data on the safety profile of the COVID-19 vector vaccine Gam-COVID-Vac (Sputnik V). Previous infodemiology studies showed that social media discourse could be analyzed to assess the most concerning adverse events (AE) caused by drugs.

Objective

We aimed to investigate mild AEs of Sputnik V based on a participatory trial conducted on Telegram in the Russian language. We compared AEs extracted from Telegram with other limited databases on Sputnik V and other COVID-19 vaccines. We explored symptom co-occurrence patterns and determined how counts of administered doses, age, gender, and sequence of shots could confound the reporting of AEs.

Methods

We collected a unique dataset consisting of 11,515 self-reported Sputnik V vaccine AEs posted on the Telegram group, and we utilized natural language processing methods to extract AEs. Specifically, we performed multilabel classifications using the deep neural language model Bidirectional Encoder Representations from Transformers (BERT) “DeepPavlov,” which was pretrained on a Russian language corpus and applied to the Telegram messages. The resulting area under the curve score was 0.991. We chose symptom classes that represented the following AEs: fever, pain, chills, fatigue, nausea/vomiting, headache, insomnia, lymph node enlargement, erythema, pruritus, swelling, and diarrhea.

Results

Telegram users complained mostly about pain (5461/11,515, 47.43%), fever (5363/11,515, 46.57%), fatigue (3862/11,515, 33.54%), and headache (2855/11,515, 24.79%). Women reported more AEs than men (1.2-fold, P<.001). In addition, there were more AEs from the first dose than from the second dose (1.1-fold, P<.001), and the number of AEs decreased with age (β=.05 per year, P<.001). The results also showed that Sputnik V AEs were more similar to other vector vaccines (132 units) than with messenger RNA vaccines (241 units) according to the average Euclidean distance between the vectors of AE frequencies. Elderly Telegram users reported significantly more (5.6-fold on average) systemic AEs than their peers, according to the results of the phase 3 clinical trials published in The Lancet. However, the AEs reported in Telegram posts were consistent (Pearson correlation r=0.94, P=.02) with those reported in the Argentinian postmarketing AE registry.

Conclusions

After the Sputnik V vaccination, Russian Telegram users reported mostly pain, fever, and fatigue. The Sputnik V AE profile was comparable with other vector COVID-19 vaccines. Discussion on social media could provide meaningful information about the AE profile of novel vaccines.
Topics and Sentiments of Public Concerns Regarding COVID-19 Vaccines: Social Media Trend Analysis
Authors: Monselise Michal , Chang Chia-Hsuan , Ferreira Gustavo , Yang Rita , Yang Christopher C
Published: September 2021

Background

As a number of vaccines for COVID-19 are given emergency use authorization by local health agencies and are being administered in multiple countries, it is crucial to gain public trust in these vaccines to ensure herd immunity through vaccination. One way to gauge public sentiment regarding vaccines for the goal of increasing vaccination rates is by analyzing social media such as Twitter.

Objective

The goal of this research was to understand public sentiment toward COVID-19 vaccines by analyzing discussions about the vaccines on social media for a period of 60 days when the vaccines were started in the United States. Using the combination of topic detection and sentiment analysis, we identified different types of concerns regarding vaccines that were expressed by different groups of the public on social media.

Methods

To better understand public sentiment, we collected tweets for exactly 60 days starting from December 16, 2020 that contained hashtags or keywords related to COVID-19 vaccines. We detected and analyzed different topics of discussion of these tweets as well as their emotional content. Vaccine topics were identified by nonnegative matrix factorization, and emotional content was identified using the Valence Aware Dictionary and sEntiment Reasoner sentiment analysis library as well as by using sentence bidirectional encoder representations from transformer embeddings and comparing the embedding to different emotions using cosine similarity.

Results

After removing all duplicates and retweets, 7,948,886 tweets were collected during the 60-day time period. Topic modeling resulted in 50 topics; of those, we selected 12 topics with the highest volume of tweets for analysis. Administration and access to vaccines were some of the major concerns of the public. Additionally, we classified the tweets in each topic into 1 of the 5 emotions and found fear to be the leading emotion in the tweets, followed by joy.

Conclusions

This research focused not only on negative emotions that may have led to vaccine hesitancy but also on positive emotions toward the vaccine. By identifying both positive and negative emotions, we were able to identify the public's response to the vaccines overall and to news events related to the vaccines. These results are useful for developing plans for disseminating authoritative health information and for better communication to build understanding and trust.
Voice Assistant Reminders and the Latency of Scheduled Medication Use in Older Adults With Pain: Descriptive Feasibility Study (Preprint)
Authors: Shade Marcia , Rector Kyle , Kupzyk Kevin
Published: September 2021

BACKGROUND

Pain is difficult to manage in older adults. It has been recommended that pain management in older adults should include both nonpharmacologic and pharmacologic strategies. Unfortunately, nonadherence to pain medication is more prevalent than nonadherence to any other chronic disease treatment. Technology-based reminders have some benefit for medication adherence, but adherence behavior outcomes have mostly been verified by self-reports.

OBJECTIVE

We aimed to describe objective medication adherence and the latency of medication use after a voice assistant reminder prompted participants to take pain medications for chronic pain.

METHODS

A total of 15 older adults created a voice assistant reminder for taking scheduled pain medications. A subsample of 5 participants were randomly selected to participate in a feasibility study, in which a medication event monitoring system for pain medications was used to validate medication adherence as a health outcome. Data on the subsample’s self-assessed pain intensity, pain interference, concerns and necessity beliefs about pain medications, self-confidence in managing pain, and medication implementation adherence were analyzed.

RESULTS

In the 5 participants who used the medication event monitoring system, the overall latency between voice assistant reminder deployment and the medication event (ie, medication bottle cap opening) was 55 minutes. The absolute latency (before or after the reminder) varied among the participants. The shortest average time taken to open the cap after the reminder was 17 minutes, and the longest was 4.5 hours. Of the 168 voice assistant reminders for scheduled pain medications, 25 (14.6%) resulted in the opening of MEMS caps within 5 minutes of the reminder, and 107 (63.7%) resulted in the opening of MEMS caps within 30 minutes of the reminder.

CONCLUSIONS

Voice assistant reminders may help cue patients to take scheduled medications, but the timing of medication use may vary. The timing of medication use may influence treatment effectiveness. Tracking the absolute latency time of medication use may be a helpful method for assessing medication adherence. Medication event monitoring may provide additional insight into medication implementation adherence during the implementation of mobile health interventions.
Initial SARS-CoV-2 Vaccination Uptake in a Correctional Setting: Cross-sectional Study (Preprint)
Authors: Berk Justin , Murphy Matthew , Kane Kimberly , Chan Philip , Rich Josiah , Brinkley-Rubinstein Lauren
Published: September 2021

BACKGROUND

The largest outbreaks of COVID-19 in the United States have occurred in correctional facilities, and little is known about the feasibility and acceptability of SARS-CoV-2 vaccine campaigns among incarcerated people.

OBJECTIVE

The aim of this study was to describe a statewide vaccination program among incarcerated people and staff working in a prison setting.

METHODS

Between December 2020 and February 2021, the Rhode Island Department of Corrections (RIDOC) offered the opportunity for SARS-CoV-2 vaccination to all correctional staff and sentenced individuals. Two RIDOC public health educators provided education on the vaccine, answered questions, and obtained consent before the vaccine clinic day for the incarcerated group. All staff received information on signing up for vaccines and watched an educational video that was created by the medical director. Additional information regarding vaccine education and resources was sent via email to the entire RIDOC department.

RESULTS

During this initial campaign, 76.4% (1106/1447) of sentenced individuals and 68.4% (1008/1474) of correctional staff accepted and received the vaccine. Four months after the first vaccine was offered, 77.7% (1124/1447) of the sentenced population and 69.6% (1026/1474) of staff were fully vaccinated.

CONCLUSIONS

This study demonstrates the feasibility and efficiency of vaccine implementation in a carceral setting. Education and communication likely played an important role in mitigating vaccine refusals.
Peer Review of “SARS-CoV-2 Vaccination Uptake in a Correctional Setting: Cross-sectional Study” (Preprint)
Authors: Anonymous Anonymous
Published: September 2021

UNSTRUCTURED

This is a peer review.
Peer Review of “SARS-CoV-2 Vaccination Uptake in a Correctional Setting: Cross-sectional Study” (Preprint)
Authors: Howell Benjamin A
Published: September 2021

UNSTRUCTURED

This is a peer review report.
COVID-19 Vaccine Perceptions, Intentions, and Uptake Among Young Adults in the United States: Prospective College-Based Cohort Study (Preprint)
Authors: Gurley Stephen , Bennett Brady , Sullivan Patrick Sean , Kiley Maryellen , Linde Jamie , Szczerbacki David , Guest Jodie
Published: September 2021

BACKGROUND

Uptake of the COVID-19 vaccine among US young adults, particularly those that belong to racial and ethnic minorities, remains low compared to their older peers. Understanding vaccine perceptions and their influence on vaccination uptake among this population remains crucial to achieving population herd immunity.

OBJECTIVE

We sought to study perceptions of COVID-19 vaccines as well as intended and actual vaccine uptake among one population of college students, faculty, and staff.

METHODS

As part of a larger study aimed at investigating the dynamics of COVID-19 transmission, serology, and perception on a college campus, participants were asked about their views on the COVID-19 vaccine in February 2021. Vaccination status was assessed by self-report in April 2021. Logistic regression was used to calculate prevalence ratios with marginal standardization.

RESULTS

We found that non-White participants were 25% less likely to report COVID-19 vaccination compared to White participants. Among those who were unvaccinated, Black and other non-White participants were significantly more likely to indicate they were unwilling to receive a COVID-19 vaccine compared to White participants. The most common reason for unwillingness to receive the vaccine was belief that the vaccine approval process was rushed.

CONCLUSIONS

There are racial differences in perceptions of the COVID-19 vaccine among young adults, and these differences might differentially impact vaccine uptake among young racial and ethnic minorities. Efforts to increase vaccine uptake among college populations might require campaigns specifically tailored to these minority groups.
A recurrent neural network-based predictive model for pressure ulcers based on an intensive care unit dataset (MIMIC-III) (Preprint)
Authors: Park Minseop , Choi Hyeok , Ahn Hee-Sung , Kang Hee-Ju , Kim Saehoon , Park Haeil , Shin Jaeyong , Cho Soo Ick
Published: September 2021

BACKGROUND

A pressure ulcer (PU) is a localized cutaneous injury caused by pressure or shear, which usually occurs in the region of a bony prominence. PUs are common in hospitalized patients and cause complications including infection.

OBJECTIVE

This study aimed to build a recurrent neural network-based algorithm to predict PUs 24 hours before their occurrence.

METHODS

This study analyzed a freely accessible intensive care unit (ICU) dataset, MIMIC- III. Deep learning and machine learning algorithms including long short-term memory (LSTM), multilayer perceptron (MLP), and XGBoost were applied to 37 dynamic features (including the Braden scale, vital signs and laboratory results, and interventions to reduce the risk of PUs) and 35 static features (including the length of time spent in the ICU, demographics, and comorbidities). Their outcomes were compared in terms of the area under the receiver operating characteristic (AUROC) and the area under the precision-recall curve (AUPRC).

RESULTS

A total of 1,048 cases of PUs (10.0%) and 9,402 controls (90.0%) without PUs satisfied the inclusion criteria for analysis. The LSTM + MLP model (AUROC: 0.7929 ± 0.0095, AUPRC: 0.4819 ± 0.0109) outperformed the other models, namely: MLP model (AUROC: 0.7777 ± 0.0083, AUPRC: 0.4527 ± 0.0195) and XGBoost (AUROC: 0.7465 ± 0.0087, AUPRC: 0.4052 ± 0.0087). Various features, including the length of time spent in the ICU, Glasgow coma scale, and the Braden scale, contributed to the prediction model.

CONCLUSIONS

This study suggests that recurrent neural network-based algorithms such as LSTM can be applied to evaluate the risk of PUs in ICU patients.
Where There's a Will, There's a Way: In-House Digitization of an Oral History Collection in a Lone-Arranger Situation
Authors: Downing-Turner Mary Elizabeth
Published: September 2021

Analog audio materials present unique preservation and access challenges for even the largest libraries. These challenges are magnified for smaller institutions where budgets, staffing, and equipment limit what can be achieved. Because in-house migration to digital of analog audio is often out of reach for smaller institutions, the choice is between finding the room in the budget to out-source a project, or sit by and watch important materials decay. Cost is the most significant barrier to audio migration. Audio preservation labs can charge hundreds or even thousands of dollars to migrate analog to digital. Top-tier audio preservation equipment is equally expensive. When faced with the decomposition of an oral history collection recorded on cassette tape, one library decided that where there was a will, there was a way. The College of Education One-Room Schoolhouse Oral History Collection consisted of 247 audio cassettes containing interviews with one-room school house teachers from 68 counties in Kansas. The cassette tapes in this collection were between 20-40 years old and generally inaccessible for research due to fear the tapes could be damaged during playback. This case study looks at how a single Digital Curation Librarian with no audio digitization experience migrated nearly 200 hours of audio to digital using a $40 audio converter from Amazon and a campus subscription to Adobe Audition. This case study covers the decision to digitize the collection, the digitization process including audio clean-up, metadata collection and creation, presentation of the collection in CONTENTdm, and final preservation of audio files. The project took 20 months to complete and resulted in significant lessons learned that have informed decisions regarding future audio conversion projects.
on ideal convergence of triple sequences in intuitionistic Fuzzy normed space defined by compact operator
Authors: Khan Vakeel A. , Imran Idrisi Mohd. , Tuba Umme
Published: September 2021

The main purpose of this article is to introduce and study some new spaces of I-convergence of triple sequences in intuitionistic fuzzy normed space defined by compact operator i.e 3SI (μ,ν)(T ) and 3SI0(μ,ν)(T ) and examine some fundamental properties, fuzzy topology and verify inclusion relations lying under these spaces.
Servicios accesibles a todos los usuarios en las bibliotecas universitarias españolas: estado de la cuestión
Authors: Domingo Pàmies David , Rey Martín Carina , Rodríguez Parada Concepción
Published: September 2021

Hasta el momento, las universidades han centrado la atención a la discapacidad en el ámbito de la docencia mediante la puesta en marcha de programas o planes que contemplan la adquisición de software específico, medidas de ayuda a la docencia y la contratación de personas de acompañamiento, entre otras estrategias. Sin embargo, los servicios universitarios, como, por ejemplo, los ofrecidos por las bibliotecas, no han mostrado el mismo nivel de adaptación. A diferencia de lo que ocurre con las bibliotecas públicas, la bibliografía centrada en accesibilidad y servicios inclusivos en bibliotecas universitarias o CRAI es muy escasa. Este trabajo pretende paliar esta carencia a partir del estudio bibliográfico y posterior análisis cualitativo de las necesidades de los usuarios con discapacidad y su atención en las bibliotecas públicas, para después revisar las buenas prácticas y los servicios específicos prestados por las universidades y sus respectivos CRAI tal como se difunden en las páginas web de cada una de ellas. Aunque el marco legal y normativo fija pautas genéricas para garantizar la accesibilidad física y a los servicios bibliotecarios, este artículo pretende concretar dichas pautas para adaptarlas a las circunstancias específicas de las bibliotecas universitarias.
HIGH-TECH MODEL OF ALBAZINSKY FORT
Authors:   I.E.Eremin Amur state university, Eremin I.E. , Korobiy E.B. ,   E.B. Korobiy  Amur State University, Natsvin A.V. ,   A.V. Natsvin Amur State University, Trukhin V.I. ,   V.I.Trukhin Amur State University, Lokhov A.Iu. ,   A.Iu.Lokhov Amur State University
Published: September 2021

The methodology of using computer technologies for scientific and metric modeling of lost wooden structures dating back to medieval period in Russian history is reviewed. The most accurate recon-struction of the Albazinsky Fort exterior as of 1685, implemented within the framework of ontological coordination of initial data maximum sampling, is presented.
Zidovudine Induced Pancytopenia: A Case Study
Authors: Simon K Santreena , Maria Serene , Tom Cyril
Published: September 2021

Zidovudine is the oldest anti-retroviral agent that is in clinical use. It’s common adverse effects are headaches (42-62.5%), nausea (46-61%), anorexia (11-20%), vomiting (6-25%), anemia (1.1-29%), granulocytopenia (1.8-37%) and neutropenia (3%).

This study is to increase awareness of Zidovudine induced pancytopenia. This is an observational type of case report of a 40 year old man with known complaints of HIV on anti-retroviral therapy since 8 years who came with complaints of easy fatigability since 1 year which was aggravated since 1 week, epigastric discomfort, constipation since 2 weeks, chest pain retrosternal in position which was radiating to both upper limbs, sweating, palpitations, decreased appetite since 1 week and cough with expectoration.

He was given tablet ZLN (Zidovudine 300 mg + Lamivudine 150 mg + Nevirapine 200 mg) twice daily regularly for the past 8 years. His last CD4 count was 300 cell/mm3. He had pallor. His laboratory results were: hemoglobin (6.6 g/dL), TLC (2400/μL), platelets (18,000/μL), neutrophil (36%) and MCV (107.4fL). He was diagnosed with pancytopenia (dimorphic anemia + leucopenia + thrombocytopenia) and neuropathic pain.

It was confirmed to be Zidovudine induced pancytopenia by objective analysis and Naranjo score suggesting “probable” interpretation. Pancytopenia improved after withholding Zidovudine along with Oxcarbazepine. Suggestion was made to change his anti-retroviral regimen once his counts improve.  Tenofovir + Lamivudine (or Emtricitabine) + Efavirenz is the preferred first line combination therapy according to latest WHO guidelines (2013 and 2015). In case Zidovudine is used in first line combination therapy (2009 WHO guidelines), physicians should monitor for its toxicity.

A clinical pharmacist can help in such situations by creating awareness among prescribers regarding latest WHO and other recommended guidelines, checking whether the prescriptions follow these guidelines and also by monitoring patients for toxicities.

Keywords: Zidovudine, Drug induced pancytopenia, Adverse drug reaction
Physicochemical, Druggable, ADMET Pharmacoinformatics and Therapeutic Potentials of Azadirachtin - a Prenol Lipid (Triterpenoid) from Seed Oil Extracts of Azadirachta indica A. Juss.
Authors: Loganathan T. , Barathinivas A. , Soorya C. , Balamurugan S. , Nagajothi T. G. , Ramya S. , Jayakumararaj R.
Published: September 2021

Azadirachtin (AZA) is the most abundant bioactive secondary metabolite (BASM) in neem seed oil extract (NSOE) of Azadirachta indica A. Juss. AZA is localised in different parts of the plant (seeds, fruits, flowers, leaves, stem, bark and root) however, with varying degree of concentration. It has been documented that maximum concentration of AZA is present to the tune of 48000 μg g-1 in the seeds. It has been established that the environmental conditions determines the overall content and composition of BASM in different parts of the plant. Neem plant parts are most commonly used as therapeutic agents in remote villages in India for its ethnomedicinal therapeutic potentials; however, its physicochemical, druggable and pharmacological properties inadequately described. In the present study an attempt has been made to evaluate the physicochemical, druggable and pharmacological properties of Azadirachtin in NSOE of A. indica from ADMET perspectives.

Keywords: NEEM; Azadirachta indica; Azadirachtin; Pharmacoinformatics; ADMET; Drug-Likeness; Toxicology
Noise-robust preparation contextuality shared between any number of observers via unsharp measurements
Authors: Anwer Hammad , Wilson Natalie , Silva Ralph , Muhammad Sadiq , Tavakoli Armin , Bourennane Mohamed
Published: September 2021

Multiple observers who independently harvest nonclassical correlations from a single physical system share the system's ability to enable quantum correlations. We show that any number of independent observers can share the preparation contextual outcome statistics enabled by state ensembles in quantum theory. Furthermore, we show that even in the presence of any amount of white noise, there exists quantum ensembles that enable such shared preparation contextuality. The findings are experimentally realised by applying sequential unsharp measurements to an optical qubit ensemble which reveals three shared demonstrations of preparation contextuality.
Memoria episódica posterior a cirugía de epilepsia del lóbulo temporal
Authors: Gutiérrez-Álvarez Cristian , Zapata-Berruecos José Fernando , Aguirre-Acevedo Daniel Camilo , Carvajal Julián Santiago , Arboleda Alejandra
Published: September 2021

INTRODUCCIÓN:
La cirugía resectiva del lóbulo temporal anterior con amigdalo-hipocampectomía es un tratamiento efectivo para la epilepsia farmacorresistente del lóbulo temporal con esclerosis hipocampal. Sin embargo, este procedimiento conlleva riesgo de deterioro de la memoria episódica verbal y no verbal postoperatoria, dependiendo de la dominancia hemisférica para la memoria y el lenguaje.

OBJETIVO:
Explorar el desenlace de la memoria episódica posterior a la cirugía resectiva mediante lobectomía temporal anterior con amigdalo-hipocampectomía.

MÉTODOS:
Se analizó retrospectivamente la memoria episódica verbal y no verbal mediante pruebas neurop-sicológicas de 51 pacientes consecutivos sometidos a lobectomía temporal anterior con amigdalo-hipocampectomía del lado izquierdo y derecho. Todos los pacientes fueron sometidos a resonancia magnética cerebral preoperatoria, video-electroencefalografía y evaluaciones neuropsicológicas. A 12 pacientes (24 %) no se les realizó el test de Wada.

RESULTADOS:
Hubo disminución en la memoria episódica verbal postoperatoria con diferencias respecto a la preoperatoria, en la subprueba de textos II recuerdo de la escala de memoria de Wechsler III (p = 0,035). El resultado en la memoria episódica visual se mantuvo igual, no hubo diferencias en el grupo de lobectomía temporal estándar.

CONCLUSIÓN:
La lobectomía temporal anterior más amigdalo-hipocampectomía izquierda afecta levemente el desempeño de la memoria episódica postoperatoria, que clínicamente no es significativo en pacientes con epilepsia del lóbulo temporal mesial farmacorresistente.
Enxertos ósseos autógeno em cranioplastia
Authors: Custódio Antonlo Luis Neto , Beltrão Gilson Côrreia , Severo Carlos Marcelo
Published: September 2021

A review of the osteoplastic reconstruction of cranioplasty has been presented. The repair of skull defects usin free osteoperiosteal grafts from the outer table of the same part of skull on the others side is described.
Gender diversity on corporate boards: Review and future research agenda through bibliometric mapping
Authors: Singh Jagvinder , Singhania Shubham , Aggrawal Deepti
Published: September 2021

With growing regulatory changes with respect to the composition of the board of directors, the regulation for the appointment of women directors on the corporate boards has seen an upsurge in recent times. It is quite evident to believe that with so many countries mandating the appointment of women, the reasons are not just social but also economic in nature. The extant literature provides enough evidence based on various social and psychological theories that support the diversity element for better decision-making. This study is an attempt to analyze the scientific articles to understand the growth of this concept under various dimensions. The search, undertaken over the Scopus database, led to the retrieval of a total of 547 articles published during the period 1989–2021 which, after final filtration, brought the total number of results to 352 articles. VOSviewer software was employed for the purpose of analyzing these articles which helped in the formulation of bibliometric citation, co-citation, and co-word maps. The findings suggest the prominent countries, significant authors, major studies, and top journals in this domain. In addition, the study also identifies the various dimensions such as financial performance, social performance, environmental performance, sustainability disclosures being impacted due to the presence of gender diversity. The study is significant and unique based on the pretext that it uses the Scopus database for the purpose of bibliometric mapping whereas past studies have used the Web of Science database, thus the study’s outcome made a strong corroboration in identifying emerging paradigms in the gender diversity literature