bluuebunny/crossref_metadata_2025 huggingface dataset:
History, Features, Challenges and Critical Success Factors of ERP in the ERA of Industry 4.0
Authors: Al-Amin Md. , Hossain Md. Tanjim , Islam Md. Jahidul , Biwas Sanjit
Published: December 2022

This paper uses a state-of-the-art review system with a purpose to review and synthesize the latest information on the possible integration of potential disruptive technologies into the future development of ERP. Different software, such as Material Requirement Planning (MRP), Manufacturing Resource Planning (MRPII), and Computer Integrated Manufacturing (CIM) have been found to be the base of existing versions of ERP. Potential disruptive Industry 4.0 technologies that can be integrated into ERP are found to be artificial intelligence, business intelligence, internet of things, big data, blockchain technology, and omnichannel strategy. Notable Critical Success Factors of ERP are top management support, project team, IT infrastructure, communication, skilled staff, training & education, and monitoring & evaluation. Moreover, cybersecurity has been found to be the most challenging issue to overcome in future versions of ERP. This paper could help the future ERP researchers and respective stakeholders contribute to integrate newer features in the future versions of ERP.
territórios quilombolas como espaço de construção e preservação da identidade
Authors: Girardon dos Santos Denise Tatiane , Pires Keitel Ângela Simone , Vargas Rocha Maria Luiza
Published: December 2022

Este artigo trata da regularização das comunidades remanescentes quilombolas como fator de preservação da memória ancestral e do patrimônio histórico e cultural do Brasil, com recorte na comunidade quilombola de Júlio Borges, localizada no interior do Município de Salto do Jacuí, Estado do Rio Grande do Sul. Objetiva-se verificar como ocorre o processo de titulação da terra e a forma com que ele impacta na vida da comunidade e na capacidade de preservação da identidade quilombola. O problema de pesquisa que se pretende responder é: o direito à terra, a partir da sua demarcação e titulação, é fator importante na preservação da memória ancestral quilombola? Para tanto, foram abordados aspectos sobre a ancestralidade quilombola e a formação de sua identidade, a legislação brasileira vigente e a demora na finalização dos processos de titulação, além de informações, coletadas na comunidade em estudo. A abordagem adotada foi a quali-quantitativa, de caráter exploratório, com a utilização do método dedutivo, com procedimentos bibliográfico e documental, bem como, pesquisa de campo, com entrevista realizada com a Vice-Presidenta da associação quilombola. Como resultado, constatou-se que, após a regularização do quilombo Júlio Borges, a comunidade passou a promover uma série de ações que contribuíram e contribuem para o fortalecimento da identidade quilombola e para a preservação da memória ancestral, além de garantir o assentamento definitivo de diversas famílias.
ISLAMIC RELIGIOUS COPING AND PROBLEMATIC-INTERNET USE WITH SELF-CONTROL IN COVID-19 PANDEMIC
Authors: Roudhotina Wardah , Uyun Qurotul
Published: December 2022

This study aimed to observe the correlation between the Islamic Religious Coping and the Problematic Internet Use (PIU) with the self-control as the mediator variable towards the university students in the COVID-19 pandemic. This study used purposive sampling technique, involved 304 active university students, male and female, 17 to 26 years old, muslim, and currently undergoing online learning. It used Iranian Religious Coping (IRCOPE) scale, Self-Control Scale (SCS), and Generalized Problematic Internet Use-2 (GPIUS-2) that have been adapted into Indonesia language. The data analysis method used is SEM analysis using the path analysis model with AMOS 26.0. It showed that Islamic religious coping had a direct effect on self-control (p=***; 0.300) and self-control could impact the problematic internet use indirectly (p=***; -0.226). However, the Islamic religious coping was not able to impact the problematic internet use (p=0.229; -0.70). This showed that the hypothesis was accepted as self-control could be the full mediator variable towards the problematic internet use.
Development of a PCR-test system for detection of the Potato spindle tuber viroid
Authors: Bessolicyna E. , Harina A.
Published: December 2022

The Potato spindle tuber viroid infects potato plants, causing a serious damage to agriculture by reducing yields. Therefore, there is a need to identify this pathogen. Viroids are RNA molecules and so cannot be detected with the immunological methods and the classical PCR. The aim of this work is to develop a method for detection of the Potato spindle tuber viroid. Primers have been selected for the reverse transcription reaction and the subsequent PCR, the annealing temperatures and the size of the amplified fragment have been calculated. Primers and reaction conditions have been tested on plant material. PCR products of the calculated size have been obtained. Determination of their nucleotide sequence confirmed the identification of the genetic material of the Potato spindle tuber viroid. Thus, this PCR test system can be used for detection of the Potato viroid and become the basis for detection of other

vegetable crops’ viroids.
Potato yield after electromagnetic treatment with weak non-ionizing impulsive fields
Authors: Zaynullin V. , Shul'gina E.
Published: December 2022

The electromagnetic treatment efficiency of potato varieties selected at the Institute of Agrobiotechnologies FRC Komi SC UB RAS has been evaluated. As estimated, the treatment significantly increased the yield of locally selected potato varieties during the vegetation period of 2021-2022.
Older Workers’ Labor and the Gig-Economy: Precarization or New Opportunities?
Authors: Nioradze Georgy
Published: December 2022

The gig-economy is a flexible form of labor characterized by project employment on digital platforms. The purpose of the article is to analyze the essence of the gig-economy in order to assess its impact on the work of the older generation. The analytical review was made taking into account the following tasks: 1) analysis of relevant literature, 2) secondary analysis of quantitative, qualitative and statistical data, 3) assessing the impact of the gig-economy on the employment of pensioners in terms of precarization. An analysis of the literature shows that the “flexibilization” of the labor market is described in ambiguous terms: a number of authors describe the positive aspects (no set schedule, growth of individuality, eradication of bureaucratic restrictions), while others focus on the negative consequences (instability of income, lack of social guarantees, overexploitation, etc.). The author highlights a number of negative risks for the elderly gig-employed (forced self-employment, vulnerability to fraud, lack of social guarantees from the employer, etc.), but comes to the conclusion that the gig economy has a fairly positive impact on the employment of the elderly: 1) social security (basic pension income and social state protection), 2) integration into a new labor reality and opportunities to improve well-being, 3) resocialization, etc. A separate advantage of selfemployment is a fiscal innovation that is beneficial for the elderly which allows pensioners to obtain the status of self-employed without sacrificing pension indexation. The scientific novelty of the study lies in analyzing the employment of the older generation through the lens of the gig-economy and precarization.
Endometriosis and adenomyosis: some aspects of medical (endocrine) treatment (part 1)
Authors:   Clinic of Women’s Health, Gynecology and Obstetrics of Professor Ebert, Ebert A.D.
Published: December 2022

Th e article presents analysis of relevant literature on risk factors and pathogenesis of endometriosis and adenomyosis. Despite of numerous studies, it has not been possible so far to formulate a unifi ed concept of the pathogenesis and etiology of endometriosis and adenomyosis. We discuss the role of cytokines, including chemokines, prostaglandins and matrix metalloproteinases, as well as disorders of steroid genesis in the pathogenesis of endometriosis. It has been shown that the main therapeutical approach for patients with endometriosis is the diff erentiated use of modern hormonal drugs, which depends on age and reproductive plans. According to the more recent European guidelines, progestogens are the drugs of the fi rst line
The interrelation between parenchymal thickness of the affected kidney and its morphological changes in hydronephrosis
Authors:   Krasnoyarsk Interdistrict Clinical Hospital No. 20 named after I.S. Berzon, Konova A.V.
Published: December 2022

Aim of study. To study the relationship between the thickness of the parenchyma of the aff ected kidney and the nature of its morphological changes. Material and methods. Archival medical records of 350 patients operated on for congenital hydronephrosis within the period 1990-2020 were processed. Th e age of patients at the time of surgery ranged from two months to 18 years. Based on the protocols of ultrasound examination of the kidneys before surgery, the parenchymal thickness defi cit was calculated. Morphological analysis of parenchymal tissue was carried out on the basis of its histological conclusion. Results. An increase in the loss of the parenchymal layer of all segments of the aff ected kidney with increasing age at the time of surgery has been revealed. Atrophic processes of the parenchyma tissue of the hydronephrotic kidney are intensifi ed with a decrease in its parenchymal thickness. Conclusion. Th e thickness of the parenchyma of the affected kidney decreases and the degree of its atrophic changes increases with increasing duration of the disease
Prevention of complications of entero-colonic anastomoses against the background of peritonitis
Authors:   Novosibirsk state medical University, Vayner Yu.S. , Guseva A.V. ,   Novosibirsk state medical University, Atamanov K.V. ,   Novosibirsk state medical University
Published: December 2022

Th e aim of the research. To improve treatment outcomes for patients requiring formation of entero-colonic anastomoses using a new method for prevention of their leakage. Material and methods. A total of 60 patients operated on for peritonitis who potentially required entero-colonic anastomosis were divided into 2 groups. Th e retrospective comparison group included 33 subjects and 27 subjects were enrolled into the prospective main group. Anastomoses for patients in the main group were formed according to the proprietary method that improves blood fl ow along the suture line. Th e method consisted in the following: the leading segment of the small intestine was crossed at an angle of 50-60° to its mesenteric edge. Th e colon stump was also formed by crossing at an angle of 50-60° to its mesenteric edge; a “window” was cut in the antimesenteric part of the colon wall: an oval-shaped area with an area corresponding to the cross-sectional area of the small intestine, the end of the small intestine was connected to the oval hole in the colon “end to side” using a single-row continuous intestinal suture. Primary endpoint: development of leakage in the formed entero-colonic anastomosis. Secondary endpoint: mortality of patients in the postoperative period until discharge from the hospital. Results. Th e proportion of leakage amounted to 3.7% in the main group, and 33.3 % in the comparison group (p=0.007). Th e mortality was 7.4 % and 36.3 %, respectively (p=0.012). Conclusion. The proposed technique for entero-colonic anastomosis formation has advantages due to a signifi cant reduction in the frequency of fistula leakage and mortality
Neutrophil extracellular traps: formation dynamics associated with the transition from remission to active rheumatoid arthritis
Authors:   Research Institute of Clinical and Experimental Rheumatology named aft er A.B. Zborovsky,, Bedina S.A. , Mozgovaya E.E. ,   Research Institute of Clinical and Experimental Rheumatology named aft er A.B. Zborovsky,, Trofimenko A.S. ,   Research Institute of Clinical and Experimental Rheumatology named aft er A.B. Zborovsky,, Mamus M.A. ,   Research Institute of Clinical and Experimental Rheumatology named aft er A.B. Zborovsky,, Spitsyna S.S. ,   Research Institute of Clinical and Experimental Rheumatology named aft er A.B. Zborovsky,, Zborovskaya I.A. ,   Research Institute of Clinical and Experimental Rheumatology named aft er A.B. Zborovsky,
Published: December 2022

Tne aim of the research. To evaluate the main parameters of neutrophil extracellular traps formation (NETosis) and their dynamics in rheumatoid arthritis (RA) patients associated with the transition from remission to active autoimmune infl ammation. Material and methods. A total of 37 patients (6 males and 31 females) with verifi ed RA according to the ACR/EULAR 2010 criteria were enrolled in the study and formed the main group. Th e comparison group was constituted by 30 healthy volunteers. Circulating neutrophils were isolated with one-step density gradient centrifugation using double layers of iohexol gradient in the original modifi cation. Th e quantitative composition of neutrophils was assessed through microscopy of smears stained according to May-Grunwald. Cell viability as well as non-specifi c activation were evaluated microscopically using trypan blue exclusion assay and nitroblue tetrazolium test, respectively. Neutrophil extracellular trap (NETs) formation was induced by 50 nM phorbol-12-myristate-13- acetate and assessed using fl uorescence microscopy. Results. Neutrophils isolated from RA patients in clinical remission have been revealed to have a higher ability for spontaneous and induced NETs formation than neutrophils from the comparison group. Th e transition from remission to active RA was characterised by a signifi cant increase in induced and, especially, spontaneous formation of NETs. Th e growth rate of spontaneous NET formation was 3.9-fold higher than the induced NETs formation. Spontaneous formation of NETs above 16.4 % may serve as a possible RA activation indicator. Neutrophils from ACPA-positive RA patients were found to have increased spontaneous and induced NETs formation compared to ACPA-negative RA patients. Conclusion. We have studied the main parameters of NETs formation and their dynamics associated with the transition from remission to active autoimmune infl ammation in RA patients. Th e activity of RA has a more pronounced eff ect on the intensity of NETs formation than the presence of ACPA. NETs may be considered a new potential diagnostic and prognostic biomarker
Studying the markers of angiogenesis and inflammation in dominant fibroids and myometrium
Authors:   Novosibirsk State Medical University, Solyanikov D.A. , Marinkin I.O. ,   Novosibirsk State Medical University, Volchek A.V. , Mikhailova E.S. ,   Novosibirsk State Medical University, Aidagulova S.V. ,   Novosibirsk State Medical University
Published: December 2022

Th e aim of the research. To study markers of angiogenesis and infl ammation in dominant fi broids and myometrium. Material and methods. Myomectomy in 226 patients of reproductive age with uterine myoma was carried out. Th e resected samples of dominant myomatous nodules and perifocal myometrium of 35 females including 12 treated using selective progesterone receptor (PgR) modulator were examined for the content of granulocyte-macrophage colony-stimulating factor (GM-CSF), vascular endothelial growth factor (VEGF) and 17-hydroxyprogesterone in the incubation medium using enzyme-linked immunosorbent assay (ELISA). Spontaneous and stimulated by polyclonal activators (PA) levels of the markers were studied. Additionally, the expression of PgR and VEGF was analysed through immunohistochemistry (IHC). Nonparametric statistics methods were used. Th e Wilcoxon test was used for intragroup comparison, the Mann-Whitney test was used for intergroup comparison. Th e correlations between biomarkers were studied using the Spearman correlation coeffi cient. Results. In the surgical specimens of leiomyoma and myometrium treated without hormone therapy, statistically signifi cant diff erences were revealed for PA-stimulated GM-CSF production incubated in vitro (2-fold lower in the nodule than in the myometrium), as well as for VEGF expression in tissue samples (2-fold higher in the nodule than in the myometrium). PgR expression in the myometrium directly correlated with the infl ammatory infi ltration of the nodule. Th e use of the selective PgR modulator contributed to the downregulation of GM-CSF production and VEGF expression in the nodule with no eff ect on the myometrium, as well as to a decrease in 17-OH-progesterone in the myometrium without changes in the nodules, and to a negative correlation between PgR expression and VEGF production in leiomyomas. Conclusion. For the dominant fi broid, application of the selective PgR modulator contributed to a downregulation of VEGF expression and to the decrease of in-vitro production of GM-CSF without infl uence on the perifocal myometrium, which demonstrates its proangiogenic and proinfl ammatory potential in patients with uterine myoma.
Understanding Human Behavior Development with Spirituality: Critical Insights into Moral Flourishing
Authors: Huda Miftachul , Salem Sultan
Published: December 2022

This paper examines the flourishing of moral enhancement through a critical investigation of Al-Zarnūjī’s Ta‘lim al-Muta‘allim. The critical reviews of the literature from refereed and peer-reviewed articles were employed using thematic topic analysis on the flourishing of moral enhancement with a special reference to Al-Zarnūjī's Ta‘lim al-Mutallim, in giving an insightful value to spiritual engagement. The results show that the subsequent phase of moral flourishing with spirituality comes from niyyah (goal-oriented commitment) as the enhanced enthusiasm derived from the continued consistency of doing goodness in the human morality indicator. This is followed with faqīhan mutawarri‘an (clear comprehension with carefulness) as comprehending personal behaviour with knowledge and moral quality. The following point supported muwāḍabah (thorough attempts) as the expansion of wide-ranging performance made for moral development and continued into sustaining individual behavioural growth with a spiritual quality. Furthermore, a discussion of implications serves to contribute to human behavioural development, with spirituality detailed into moral behaviour through spiritual quality enhancement, as well as the continued awareness of ethical behaviour sustainability and knowledgeable practice quality progression.
Analysis of Business Intelligence Systems Transmission Session
Authors: Ahmadzai Abdul Shabir , Yazdani Qurban , Abubakar Adamu
Published: December 2022

Information and Communication Technology (ICT) is the central part of Intelligent systems. Business Intelligence (BI) utilizes ICT resources and capabilities to enhance decision-making from the available information. One of the core components of ICT resources is the network. Hypertext Transfer Protocol (HTTP) is an application layer protocol in a network model responsible for handling "requests" in a transmission session. Transmission Control Protocol (TCP) establishes connections session and keeps track of the state of the communication session. Unfortunately, a request from a critical online transaction over TCP in a BI environment is bound to face some uncertainty. There is a lack of studies on the impact of communication over transmission sessions on BI operations. This paper presented an experimental evaluation of the BI transaction transmission session. Various transactions were performed to monitor and analyze the request made with HTTP over a TCP transmission session. Both the HTTP and TCP features for all transactions were captured. The finding indicates that time is highly associated with less traffic congestion and transaction overhead.
Estudio Anatómico e Histológico de la Glándula Mamaria del Cuy (Cavia porcellus) en las Razas Andina y Perú
Authors: Carranza Marín Dennis , Valencia León Roberto , Chauca Francia Lilia , Torres Polo Luis , Orrego Vásquez Fernando
Published: December 2022

El objetivo del estudio fue analizar anatómica e histológicamente la glándula mamaria del cuy. Para el estudio descriptivo de las glándulas mamarias se utilizaron 16 cuyes hembras divididos en 2 grupos: 8 cuyes de raza Perú y 8 cuyes de raza Andina. Cada grupo se dividió en subgrupos conformados por: 2 cuyes de 8 semanas de edad, 3 de 21 semanas de edad y 3 de 34 semanas de edad. En ellos se evaluó la conformación microscópica y macroscópica de las estructuras que conformaban la glándula mamaria del cuy, sus modificaciones y características influenciadas por la edad. Para la evaluación histológica se realizaron 33 láminas en las cuales se estudiaron muestras de la porción glandular secretora y el pezón.  En la porción glandular se observó la conformación de los lóbulos y lobulillos mamarios que se encontraban en diferentes etapas del proceso secretor; en el pezón se encontró un epitelio estratificado plano queratinizado y también el predominio el tejido conjuntivo denso irregular.  La evaluación anatómica mostró una forma discoidal conformada por 2 ejes (eje mayor con dirección cráneo lateral y eje menor). Estas se ubicaban en posición inguinal relacionada con la cara medial del muslo y de superficie lobulada. El pezón se encontró situado en el cuadrante posterior derecho de la glándula mamaria y mostró una posición vertical, recta y flexible.
Resonance imaging on the surgical management of newly diagnosed breast cancer
Authors:   Department of General and Oncologic Surgery, Faculty of Medicine Rijeka, University Hospital Center Rijeka, Rijeka, Croatia, Grebić Damir , Valković-Zujić Petra , Pozderac Iva , Kustić Domagoj , Hrboka-Zekić Matea
Published: December 2022

Introduction: Breast cancer is the most commonly diagnosed malignancy in women and the leading cause of cancer death in women. Tumor size is a critical factor in determining the type and extent of surgical and oncologic treatment. It is accurately determined by imaging modalities such as mammography, ultrasound, and magnetic resonance imaging (MRI), which provide a more reliable determination of tumor size. The aim of our study was to investigate the impact of preoperative breast magnetic resonance imaging on surgical treatment of newly diagnosed breast cancer. Material and Methods: The study retrospectively reviewed the records of 241 participants with newly diagnosed breast cancer who underwent preoperative mammography, breast ultrasound, and MRI between 2016 and 2020 at University Hospital Centre Rijeka. Patients were diagnosed with invasive ductal carcinoma, invasive lobular carcinoma, ductal carcinoma in situ, or a combination of the types. Surgical treatment included one of the following procedures: simple quadrantectomy, quadrantectomy and sentinel lymph node biopsy, quadrantectomy and axillary lymph node dissection, mastectomy and sentinel biopsy, or mastectomy and axillary dissection. Results: Compared with histopathologic tumor size, breast MRI overestimated size in 10% of patients. T stage was underestimated in 5% of patients (p>0.050). In comparison, breast ultrasound overestimated tumor size in 12% and underestimated it in 48% (p<0.001). Similarly, mammography overestimated tumor size in 14% and underestimated it in 62% (p<0.001). Conclusion: In patients with newly diagnosed breast cancer, the use of preoperative breast MRI as an adjunct to mammography and ultrasound for locoregional staging significantly alters subsequent surgical treatment.
JÓVENES “SIN RELIGIÓN”: DESDE UNA RELACIÓN LINEAL A UNA TRAYECTORIA ABIERTA EN LAS VINCULACIONES ENTRE CREENCIA, RELIGIÓN E IGLESIA
Authors: Baeza Correa Jorge
Published: December 2022

RESUMEN: Las encuestas internacionales, como también las propias de Chile, dan cuenta de un proceso creciente de personas y en especial jóvenes que, consultadas por su religión, responden marcando el casillero “sin religión”. No obstante, aún resultan escasos los trabajos que intentan profundizar cualitativamente sobre la materia y más aún, aquellos que buscan una compresión de ello. Este artículo, siguiendo las elaboraciones de Danièle Hervieu-Léger, trabaja con la hipótesis de que detrás de este fenómeno, estaría presente una ruptura en la linealidad existente, por muchas décadas, entre creencia, religión e iglesia. A través de una revisión sistematizada de artículos referidos a jóvenes sin religión, escritos en Latinoamérica y publicados en los últimos cinco años, se busca validar argumentativamente dicha hipótesis.
PALABRAS CLAVES: Sociología de la religión. América Latina. Chile. Juventud. Sin religion
Probleme einer europaorientierten Bildungspolitik
Authors: Ohlendorf Edmund
Published: December 2022

Im ersten Kapitel dieses Aufsatzes wird gezeigt, welche Aspekte beim „Thema EU“ im Schulunterricht von 7 verschiedenen Mitgliedsländern behandelt werden. Dabei werden auch Schwierigkeiten genannt, die beim Unterricht über EU-Themen auftreten. Es wird offenkundig, dass solche Themen in fast allen EU-Mitgliedsländern keine zentrale Rolle einnehmen und in der Regel als Anhang zum Geschichtsunterricht behandelt werden. Außerdem gibt es in den meisten EU-Ländern keine spezifische Lehrerausbildung für ein Fach Politik oder Gemeinschaftskunde. Die Bildungspolitik spielte in der Ent-wicklung der EU zunächst keine große Rolle und gewinnt erst seit einigen Jahren zunehmend an Bedeutung. Im zweiten Kapitel wird dargelegt, in welchem Umfang nationale und transnationale Projekte aus allen Bildungsbereichen mit europäischen Mitteln gefördert werden mit dem Ziel, das Bildungsniveau in den EU-Mitgliedsländern zu heben und eine engere Zusammenarbeit zu ertüchtigen. Und im dritten Kapitel wird am Beispiel Italiens gezeigt, wie sich ein ehemaliges Gründungsmitglied der EU sowohl durch strukturelle Bedingungen als auch durch politisches und wirtschaftliches Fehl-verhalten zu einer Bedrohung für den Zusammenhalt in der EU entwickeln kann.
Reseña del libro PEUGNY, C. (2022): Pour une politique de la jeunesse. Paris: Seuil.
Authors: URTEAGA Eguzki
Published: December 2022

Reseña del libro PEUGNY, C. (2022): Pour une politique de la jeunesse. Paris: Seuil.
The Evolutionary History of a DNA Methylase Reveals Frequent Horizontal Transfer and Within-Gene Recombination
Authors: Gosselin Sophia P. , Arsenault Danielle R. , Jennings Catherine A. , Gogarten Johann Peter
Published: December 2022

Inteins, often referred to as protein introns, are highly mobile genetic elements that invade conserved genes throughout the tree of life. Inteins have been found to invade a wide variety of key genes within actinophages. While in the process of conducting a survey of these inteins in actinophages we discovered that one protein family of methylases contained a putative intein, and two other unique insertion elements. These methylases are known to occur commonly in phages as orphan methylases (possibly as a form of resistance to restriction-modification systems). We found that the methylase family is not conserved within phage clusters and has a disparate distribution across divergent phage groups. We determined that two of the three insertion elements have a patchy distribution within the methylase protein family. We also found that the third insertion element is likely a second homing endonuclease, and that all three elements (the intein, the homing endonuclease, and what we refer to as the ShiLan domain) all have different insertion sites that are conserved in the methylase gene family. Furthermore, we find strong evidence that both the intein and ShiLan domain are partaking in long distance horizontal gene transfer events between divergent methylases in disparate phage hosts within the already dispersed methylase distribution. The reticulate evolutionary history of methylases and their insertion elements reveals high rates of gene transfer and within-gene recombination in actinophages.
Epitope Coverage of Anti-SARS-CoV-2 Nucleocapsid IgA and IgG Antibodies Correlates With Protection Against Re-Infection by New Variants in Subsequent Waves of the COVID-19 Pandemic
Authors: Mullins Michelle O. , Smith Muneerah , Maboreke Hazel , Nel Andrew J. M. , Ntusi Ntobeko A. B. , Burgers Wendy A. , Blackburn Jonathan M.
Published: December 2022

The COVID-19 pandemic continues to affect individuals across the globe, with some individuals experiencing more severe disease than others. The relatively high frequency of re-infections and breakthrough infections observed with SARS-CoV-2 highlights the importance of extending our understanding of immunity to COVID-19. Here we aim to shed light on the importance of antibody titers and epitope utilization in protection from re-infection. Health care workers are highly exposed to COVID-19 and are therefore also more likely to become re-infected. We utilized quantitative, multi-antigen, multi-epitope SARS-CoV-2 protein microarrays to measure IgG and IgA titers against various domains of the nucleocapsid and spike proteins. Potential re-infections in a large, diverse health care worker cohort (N=300) during the second wave of the pandemic were identified by assessing the IgG anti-N titers before and after the second wave. We assessed epitope coverage and antibody titers between the 'single infection’ and ‘re-infection’ groups. Clear differences were observed in the breadth of the anti-N response before the second wave, with the epitope coverage for both IgG (p=0.019) and IgA (p=0.015) being significantly increased in those who did not become re-infected compared to those who did. Additionally, the IgG anti-N (p=0.004) and anti-S titers (p=0.018) were significantly higher in those not re-infected. These results highlight the importance of the breadth of elicited antibody epitope coverage following natural infection in protection from re-infection and disease in the COVID-19 pandemic.
Layer-by-Layer Deposited Multi-Modal PDAC/rGO Composite-based Sensors
Authors: Al-Hamry Ammar , Lu Tianqi , Bai Jing , Adiraju Anurag , Ega Tharun K. , Pašti Igor A. , Kanoun Olfa
Published: December 2022

Precise monitoring of different environmental parameters and contaminations during food processing and storage is a key factor for maintaining its safety and nutritional value. Thus, developing reliable, efficient, cost-effective sensor devices for these purposes is of utmost importance. In this paper, we show that Poly-(diallyl-dimethylammonium chloride)/reduced Graphene oxide (PDAC/rGO) films produced by a simple Layer-by-Layer deposition can be effectively used to monitor temperature, relative humidity and the presence of volatile organic compounds as indicators for spoilage odors. At the same time, they show potential for electrochemical detection of organophosphate pesticide dimethoate. By monitoring the resistance/impedance changes during temperature and relative humidity variations or upon the exposure of PDAC/rGO films to methanol, good linear responses were obtained in the temperature range of 10-100 °C, 15-95 % relative humidity, and 35 ppm - 55 ppm of methanol. Moreover, linearity in the electrochemical detection of dimethoate is shown for the concentrations in the order of 102 µmol dm−3. The analytical response to different external stimuli and analytes depends on the number of layers deposited, affecting sensors’ sensitivity, response and recovery time, and long-term stability. The presented results could serve as a starting point for developing advanced multimodal sensor devices and sensor arrays with high potential for analytical applications in food safety and quality monitoring.
Using HyperLogLog to Prevent Data Retention in Social Media Streaming Data Analytics
Authors: Löchner Marc , Burghardt Dirk
Published: December 2022

Social media data is widely used to gain insights about social incidents, whether on a local or global scale. Within the process of analyzing and evaluating the data, it is common practice to download and store it locally. Considerations about privacy protection of social media users are often neglected thereby. However, protecting privacy when dealing with personal data is demanded by laws and ethics. In this paper we introduce a method to store social media data using the cardinality estimator HyperLogLog. Based on an exemplary disaster management scenario, we show that social media data can be analyzed by counting occurrences of posts, without becoming in possession of the actual raw data. For social media data analyses like these, that are based on counting occurrences, cardinality estimation suffices the task. Thus, the risk of abuse, loss or public exposure of the data can be mitigated and privacy of social media users can be preserved. The ability to do unions and intersections on multiple data sets further encourages the use of this technology. We provide a proof-of-concept implementation for our introduced method, using data provided by the Twitter API.
Bariatric Surgery and Vitamin D: Trends in Older Women and Association with Clinical Features and VDR Gene Polymorphisms.
Authors: Benito Linconl Agudo Oliveira , Kogawa Evelyn Mikaela , Silva Calliandra Maria de Souza , Melo Fabíola Ferreira , Sales-Peres Silvia Helena de Carvalho , Silva Izabel Cristina Rodrigues da , Karnikowski Margô Gomes de Oliveira
Published: December 2022

(1) Background: Obesity and its comorbidities can cause burdens and limitations. Bariatric surgery (BS) is indicated as a safe procedure to reduce body mass and improve present comorbidities. Yet, several complications were reported, like vitamin D [25(OH)D] deficiency. We evaluated if 25(OH)D serum levels relate to clinical characteristics, symptoms, or habits in women after their BS and whether the vitamin D receptor (VDR) gene's TaqI and FokI polymorphisms affected 25(OH)D levels and the total body bone mineral density (TBBMD). (2) Methods: This cohort cross-sectional comparative analytical prospective study consisted of 27 women, 61.6 ± 5.0 years, submitted to BS one year prior at a public reference hospital, DF-Brazil. All participants were asked to follow the physical and dietary activity recommendations and received vitamin D3 supplements. Their anthropometric, biochemical, and immunological measurements and blood samples were obtained. (3) Results: 73.3% of participants had low 25(OH)D levels, and their levels correlated positively with TBBMD and negatively with systolic pressure. VDR TaqI did not affect 25(OH)D levels, whereas VDR FokI's allele f presence correlated to a median rise in 25(OH)D levels. Neither polymorphism correlated to TBBMD. (4) Conclusions: 25(OH)D levels were positively correlated with TBBMD, negatively with systolic blood pressure, and were higher in those with the VDR FokI allele f.
Spectral Matching of Three-Component Seismic Ground Accelerations for Critical Structures
Authors: Mangkoesoebroto Sindur , Yasa Adi , Zulkifli Ediansjah
Published: December 2022

This study introduces a new procedure for three-component spectral matching of seismic ground acceleration records. The procedure involves preserving the phase angle and varying the Fourier amplitudes to match the spectra of the recorded records with a provided target spectrum that represents the spectral values of ground motions in three orthogonal directions. Several three-component recorded records were matched against two target response spectra to test the method. An accurate convergence was achieved in the velocity and displacement records. In addition, the scales among the components’ magnitude were maintained, creating realistic three-component ground motions. Such ground motion inputs are important to qualify critical structures sensitive to three-component motions. Our proposed procedure is novel because the present practices are mostly created based on one-component ground motions.
Gymnema Sylvestre Supplementation Restores Normoglycemia and Corrects Dyslipidemia through Transcriptional Modulation of ßeta Cells and Hepatocytes in the Alloxan-Induced Hyperglycemic Rats
Authors: Muzaffar Humaira , Qamar Iqra , Bashir Muhammad , Jabeen Farhat , Irfan Shahzad , Anwar Haseeb
Published: December 2022

The effect of Gymnema Sylvestre supplementation on beta cell and hepatic activity was explored in an alloxan-induced hyperglycemic rat model. Adult rats were made hyperglycemic via a single inj. (i.p) of Alloxan (120mg/kg b.w). Gymnema Sylvestre was supplemented @250mg/kg and 500mg/kg b.w. Blood glucose levels were constantly monitored. After 21 days, rats were euthanized, and blood and tissues (pancreas and liver) were collected for biochemical, expression, and histological analysis. One-way ANOVA was used to compare the means of different treatment groups. Gymnema Sylvestre significantly reduced blood glucose levels with a subsequent increase in plasma insulin levels in a dosage-dependent manner. Total oxidant status (TOS), malondialdehyde, LDL, VLDL, ALT, AST, triglyceride, total cholesterol, total protein, C-reactive protein, and cortisol levels were reduced significantly in alloxan-treated hyperglycemic rats supplemented with Gymnema Sylvestre as compared to control. Significantly raised paraoxonase, arylesterase, albumin, and HDL levels were also observed in Gymnema Sylvestre supplemented hyperglycemic rats. Increased mRNA expression of Ins-1, Ins-2, Gck, Pdx1, Mafa, and Pax6 were observed, while decreased expression of Cat, Sod1, Nrf2, and NF-kB was observed in the pancreas. Whereas increased mRNA expression of Gck, Irs1, SREBP1c, and Foxk1 and decreased expression of Irs2, ChREBP, Foxo1, and FoxA2 were observed in the liver. The current study indicates the potent effect of Gymnema Sylvestre on the transcription modulation of the insulin gene in the alloxan-induced hyperglycemic rat model. Enhanced plasma insulin levels further help to improve hyperglycemia-induced dyslipidemia through transcriptional modulation of hepatocytes.
DEHA-Net: Dual-Encoder based Hard Attention Network with Adaptive ROI Mechanism for Lung Nodule Segmentation
Authors: Usman Muhammad , Shin Yeong Gil
Published: December 2022

Measuring pulmonary nodules accurately can help with early diagnosis of lung cancer, which can improve a patient’s chances of survival. Many methods for segmenting nodules have been developed, but they all rely on input from radiologists in the form of a 3D volume of interest (VOI) or use a constant region of interest (ROI) and only consider the presence of nodule within the given VOI. These approaches limit the networks’ ability to detect nodules outside the given VOI and can also include unnecessary structures in the VOI, leading to potentially inaccurate segmentation. In this work, we propose a novel approach for 3D lung nodule segmentation by using 2D region of interest (ROI) inputted from radiologist or computer-aided detection (CADe) system. Particularly, we design a dual-encoder-based hard attention network (DEHA-Net) which incorporates the full slice of thoracic computed tomography scan along with the ROI mask to produce an accurate segmentation mask of lung nodule in the given slice. The proposed architecture exploits the adaptive region of interest (A-ROI) algorithm to automatically investigates the penetration of lung nodule into surrounding slices while eliminating the need to drawing separate ROIs in each slice. Further, the framework performs the multi-view analysis, i.e., in sagittal and coronal views, to improve the segmentation performance. The proposed scheme has been rigorously evaluated on the lung image database consortium and image database resource initiative (LIDC/IDRI) dataset and an extensive analysis of results have been performed. The quantitative analysis shows that the proposed method not only improves the existing state-of-the-art in term of dice score but also, significantly robust against the different types, shape and dimensions of lung nodules.
Identification of Actual Bibliometric/Scientometric Issues Based on 2018-2022 Data from the Lens Platform by Building Key Term Co-occurrence Network
Authors: Chigarev Boris
Published: December 2022

The purpose of this article is to demonstrate the ability of bibliometric data from the Lens platform to identify relevant bibliometric/scientometric issues based on the construction of a network of key terms co-occurrence and their clustering. The advantages of using the Lens platform for bibliometric analysis are briefly demonstrated. Key terms were selected on the basis of n-grams and noun phrases. VOSviewer, Scimago Graphica, and Sifaka text mining application were used as analytical tools. Analysis of the Lens metadata on bibliometrics/scientometrics showed their predominant use in the political, social, and medical fields of research.
An IoT-based Bi-Cluster Forecasting using Automated ML-Model Optimization for COVID19
Authors: Tariq Hasan , Touati Farid , Crescini Damiano , Mnaouer Adel Ben
Published: December 2022

The current COVID19 pandemic has raised huge concerns for outdoor air quality due to expected lungs deterioration. These concerns include the challenges in the scalable prediction of harmful gases like carbon dioxide, iterative/repetitive inhaling due to mask and environmental temperature harshness. Even in the presence of air quality sensing devices, these challenges lead to failed planning and strategy against respiratory diseases, epidemics, and pandemics in severe cases. In this work, a dual time-series with bi-cluster sensor data-stream-based novel optimized regression algorithm was proposed with optimization predictors and optimization responses that use automated iterative optimization of the model based on the similarity coefficient index. The algorithm was implemented over SeReNoV2 sensor nodes data, i.e. multi-variate dual time-series of environmental and US Environmental Protection Agency standard sensor variables for air quality index measured from air quality sensors with geospatial profiling. The SeReNoV2 systems were placed at four locations that were 3 km apart to monitor air quality and their data was collected at Ubidots IoT platform over GSM. Results have shown that the proposed technique achieved a root mean square error (RMSE) of 1.0042 with a training time of 469.28 seconds for normal and RMSE of 1.646 in the training time of 28.53 seconds for optimization. The estimated R-Squared error of 0.03 with Mean-Square Error for temperature 1.0084 ᵒC and 293.98 ppm for CO2 was observed. Furthermore, the Mean-Absolute Error (MAE) for temperature 0.66226 ᵒC and 10.252 ppm for CO2 at a prediction speed of ~5100 observations/second for temperature 45000 observations/second for CO2 due to iterative optimization of the training time 469.28 seconds for temperature and 28.53 seconds for CO2 was very promising in forecasting COVID19 countermeasures before time.
Thermal and Stress State of the Intermediate Pressure Rotor of the Power Unit № 11 of Burshtyn TPP
Authors: Chernousenko Olga , Rindyuk Dmitro , Peshko Vitalii
Published: December 2022

Thermal power plants produce about a third of the total electricity generation in the United Energy System of Ukraine and provide maneuvering capacity. The work presents the results of research aimed at analyzing the reliability of thermal power equipment. The thermal and stress state of the medium-pressure rotor of power unit No. 11 of the Burshtyn TPP was investigated. When conducting calculation experiments, both the design geometry and samples of the rotor metal in the places where cracks appeared were taken into account. The temperature distribution and their gradients were calculated to solve the problem of the stress-strain state. The highest values ​​of stress intensity amplitudes are observed in the zone of end seals, which is explained by the more significant influence of the accumulation of low-cycle fatigue as a mechanism of destruction, compared to the exhaustion of the long-term strength of the metal in the stationary mode of operation.
SYNTHESIS OF ELECTRIC HYDRAULIC FOLLOWING DRIVE PARAMETERS BASED ON THE PRESCRIBED ACCURACY OF POSITIONING OF THE WORKING BODY, FAST SPEED AND CHARACTER OF THE TRANSITION PROCESS
Authors: Stryzhak Mariana , Krutikov Gennady
Published: December 2022

A methodology for the dynamic synthesis of an electro-hydraulic servo drive is described to ensure a given performance, a given transient shape and accuracy of the positioning of the working body. The structural scheme of the electro-hydraulic tracking drive was constructed, on the basis of which its mathematical model was compiled based on the equations of the dynamic balance of the system. Based on the obtained transfer functions of individual elements, a structural diagram of the system was constructed. During dynamic analysis and synthesis by the method of logarithmic amplitude-phase-frequency characteristics, the transfer function of an open drive is considered, given in the form of the product of transfer functions of three typical links - integrating, aperiodic and oscillatory. The primary and secondary errors are determined and expressions for the system Q factor are obtained. Based on the given requirements for positioning accuracy, the forbidden region in the low-frequency part of the logarithmic amplitude-frequency characteristics is determined. The forbidden region in the mid-frequency part of the logarithmic amplitude-frequency characteristics is also determined based on the given dynamic characteristics of the drive. Real and desired logarithmic amplitude-frequency and phase-frequency characteristics are constructed. Since the existing drive structure could not fully satisfy the requirements, it was decided to introduce a corrective link into the structural diagram, formulated the requirements for the structure of the corrective link and its transfer function. The parameter that is to be adjusted in the system is determined - the gain of the electronic amplifier. This made it possible to obtain a drive that fully meets the set requirements.
Keywords: electrohydraulic servo drive, logarithmic characteristics, quality factor, corrective link
RIGID PROPERTIES OF ELASTIC BUSHINGS OF ENGINES HIGH SPEED ELEMENTS
Authors: Tkachuk Mykola M. , Grabovskiy Andrey , Prokopenko Mykola , Shut Oleksandr , Pinchuk Nataliya , Tkachuk Mykola А. , Klochkov Illia , Lipeiko Andrii , Tsendra Heorgii , Shevchenko Andriy , Koba Andrii
Published: December 2022

In the work, theoretical foundations of behavior analysis of elastic bushings of modern engines high-speed elements under load were created. Several variation settings are offered. The first one of them is based on the model of a thin ring. The second model is formed on a flat setting. The third model is a three-dimensional formulation of the contact problem. It was established that during radial force loading, uneven deformation of the elastic intermediate ring occurs. At the same time, the contact zones gradually change their location in the direction of the radial force. The dependence of the radial displacement on the loading force is significantly nonlinear. It was established that the static characteristic of an elastic ring has a complex form. Unlike the traditional linear characteristic, it consists of three sections. The first one corresponds to a zero reaction to the action of the load. The second is a linear part. The third is a tough section. Thus, new formulations of the problem of determining the stress-strain state of an elastic intermediate ring, taking into account the contact interaction, have been developed. This forms, in contrast to traditional linear, significantly nonlinear models of the stress-strain state. They are more adequate and take into account factors that were not taken into account before. In particular, the clearances, tension and contact in the coupling of the elastic intermediate ring with other parts of the structure of the support of the rotor system are taken into account.
Keywords: high-speed element, elastic bushing, support, critical rotational speeds, air blower, internal combustion engine