bluuebunny/crossref_metadata_2025 huggingface dataset:
MiRNA-Mediated Regulation of the SWI/SNF Chromatin Remodeling Complex Controls Pluripotency and Endodermal Differentiation in Human ESCs
Authors: Wade Staton L. , Langer Lee F. , Ward James M. , Archer Trevor K.
Published: June 2015

MicroRNAs and chromatin remodeling complexes represent powerful epigenetic mechanisms that regulate the pluripotent state. miR-302 is a strong inducer of pluripotency, which is characterized by a distinct chromatin architecture. This suggests that miR-302 regulates global chromatin structure; however, a direct relationship between miR-302 and chromatin remodelers has not been established. Here, we provide data to show that miR-302 regulates Brg1 chromatin remodeling complex composition in human embryonic stem cells (hESCs) through direct repression of the BAF53a and BAF170 subunits. With the subsequent overexpression of BAF170 in hESCs, we show that miR-302's inhibition of BAF170 protein levels can affect the expression of genes involved in cell proliferation. Furthermore, miR-302-mediated repression of BAF170 regulates pluripotency by positively influencing mesendodermal differentiation. Overexpression of BAF170 in hESCs led to biased differentiation toward the ectoderm lineage during EB formation and severely hindered directed definitive endoderm differentiation. Taken together, these data uncover a direct regulatory relationship between miR-302 and the Brg1 chromatin remodeling complex that controls gene expression and cell fate decisions in hESCs and suggests that similar mechanisms are at play during early human development. Stem Cells  2015;33:2925—2935
RIALS: RSU/INS‐aided localization system for GPS‐challenged road segments
Authors: Zarza Himan , Yousefi Saleh , Benslimane Abderrahim
Published: June 2015

This paper introduces a new vehicle localization approach for global positioning system‐challenged road segments (e.g., tunnels), which takes advantage of roadside units (RSUs) and in‐vehicle inertial navigation system (INS). In the proposed approach, namely RSU/INS‐aided localization system (RIALS), vehicles only need one RSU in their transmission range for an accurate positioning. The beacons received from the RSU along with the information provided by the INS system are used for establishing and maintaining particular locus circles. After linearization, the system of locus circle equations is solved using the linear least square estimation technique, and the estimated vehicle's position is obtained. In the presence of speed variations and existing ranging and INS estimation errors, the proposed RIALS adaptively sets the sufficient number of required locus circles, aiming at keeping the localization error below a given threshold. We study the effects of ranging and INS estimation errors on localization accuracy of RIALS from analytical and simulation perspectives. Results of extensive simulations show that the localization error is more sensitive to the ranging error than the INS error. Moreover, the network traffic overhead of the proposed method is considerably lower than other competitive localization approaches. Copyright © 2015 John Wiley & Sons, Ltd.
Combined FRM and GDFT filter bank designs for improved nonuniform DSA channelisation
Authors: Palomo‐Navarro Álvaro , Farrell Ronan J. , Villing Rudi
Published: June 2015

Multistandard channelisation for base stations is a big application of generalised discrete Fourier transform modulated filter banks (GDFT‐FBs) in digital communications. For technologies such as software‐defined radio and cognitive radio, nonuniform channelisers must be used if frequency bands are shared by different standards. However, GDFT‐FB‐based nonuniform channelisers can suffer from high filter orders when applied to wideband input signals. In this paper, various combinations of GDFT‐FB with the frequency response masking technique are proposed and evaluated for both uniform and nonuniform channelisation applications. Results show that the proposed techniques achieve savings in both the number of filter coefficients and the number of operations per input sample. Copyright © 2015 John Wiley & Sons, Ltd.
New insights into pri‐miRNA processing and accumulation in plants
Authors: Zhang Shuxin , Liu Yuhui , Yu Bin
Published: June 2015

MicroRNAs (miRNAs) regulate many biological processes such as development, metabolism, and others. They are processed from their primary transcripts called primary miRNA transcripts (pri‐miRNAs) by the processor complex containing the RNAse III enzyme, DICER‐LIKE1 (DCL1), in plants. Consequently, miRNA biogenesis is controlled through altering pri‐miRNA accumulation and processing, which is crucial for plant development and adaptation to environmental changes. Plant pri‐miRNAs are transcribed by DNA‐dependent RNA polymerase II (Pol II) and their levels are determined through transcription and degradation, whereas pri‐miRNA processing is affected by its structure, splicing, alternative splicing, loading to the processor and the processor activity, which involve in many accessory proteins. Here, we summarize recent progresses related to pri‐miRNA transcription, stability, and processing in plants. WIREs RNA 2015, 6:533–545. doi: 10.1002/wrna.1292

This article is categorized under:

Regulatory RNAs/RNAi/Riboswitches > Biogenesis of Effector Small RNAs
Gradual Cerium Valence Change in the Solid Solution CeRu1–xPdxAl (x = 0.1–0.9)
Authors: Niehaus Oliver , Janka Oliver
Published: June 2015

The solid solution CeRu1–xPdxAl was synthesized for x = 0.1–0.9 from the elements by arc‐melting and subsequent annealing and characterized by powder X‐ray diffraction. All members crystallize in the orthorhombic LaNiAl type structure, space group Pnma. The lattice parameters range from a = 718–722, b = 412–426, and c = 1588–1620 pm, but no linear change of the lattice parameters was found. Magnetic measurements reveal intermediate cerium valences, which change to more trivalent cerium with increasing Pd content. The susceptibility data was interpreted by either the Inter‐Configuration Fluctuation (ICF) model or the Curie‐Weiss law.
Synthesis, Structures and Magnetic Properties of Cyano‐bridged FeIII/MnIII Heterobimetallic 1D Chain Complexes
Authors: Gao Feng , Zhu Guang‐Zhou , Yang Liu
Published: June 2015

Using the tricyanometalate building block, (nBu4N)[(Tp*)Fe(CN)3] [Bu4N+ = tetrabutylammonium cation; Tp*– = hydrotris(3,5‐dimethylpyrazol‐1‐yl)borate], and bidentate Schiff base ligands, HL1 or HL2 {HL1 = 2‐[[(2‐phenylethyl)imino]methyl]phenol; HL2 = 4‐methoxy‐2‐[[(2‐phenylethyl)imino]methyl]phenol}, two heterobimetallic one‐dimensional (1D) chain complexes, [Mn(L1)2Fe(Tp*)(CN)3]n (1) and [Mn(L2)2Fe(Tp*)(CN)3]n (2), were synthesized. Single crystal X‐ray diffraction reveal the formation of neutral cyano‐bridged zigzag single chains in 1 and 2. Magnetic studies demonstrate that both complexes show ferromagnetic interactions between central FeIII and MnIII atoms.
Anion Coordination of Bis‐bisurea Ligands: Aggregation of Dihydrogen Phosphate Anion into Oligomers and Infinite Chains
Authors: Wu Biao , Huo Cuirong , Li Shaoguang , Zhao Yanxia , Yang Xiao‐Juan
Published: June 2015

A series of alkanediyl‐spaced bis‐bisurea ligands (L2–L4) were synthesized and their anion coordination behavior studied. These ligands form interesting complexes with polymeric and oligomeric dihydrogen phosphate aggregates in the solid state. The ligands L2 and L3 coordinate with H2PO4– anions to form a unique molecular “necklace” with an infinite (H2PO4–)n chain and surrounding ligand molecules. Meanwhile, two different dihydrogen phosphate‐water oligomers, (H2PO4)6·(H2O)4 and (H2PO4)4·(H2O)2, were observed in the complexes with the ligands L3 and L4. In addition, solution anion binding properties of the ligands were studied by 1H NMR and UV/Vis spectroscopy.
Strategies for stiffness analysis of laminates with microdamage: combining average stress and crack face displacement based methods
Authors: Varna Janis
Published: June 2015

Many approximate analytical models have been developed to calculate stress state between intralaminar cracks with the aim to predict the degradation of certain elastic property (most often axial modulus or shear modulus) of cross‐ply laminate. Often they are plane stress solutions and laminate constants like Poisson's ratios cannot be considered. On the other hand the so called GLOB‐LOC approach, presented in WWFE III, allows calculation of any thermo‐elastic property of a general symmetric laminate with an arbitrary number of cracks in each layer provided that two local parameters – average and normalized crack opening displacement (COD) and crack face sliding displacement (CSD) are known. In this paper relationships are derived expressing these two parameters (COD and CSD) with average value of transverse stress and in‐plane shear stress perturbation between cracks. Expressions are exact and independent on the approximations in the stress model. As examples, average perturbation functions for two shear lag models and Hashin's variational model are used to calculate damaged laminate properties that would not be available in original formulation: Poisson's ratio and thermal expansion coefficients. Predictions are compared with test data for GF/EP laminates and with more accurate predictions based on FEM calculations.
Age Constraints of Udayagiri Domain of Nellore Schist Belt by Xenotime Dating around Pamuru, Prakasam District, Andhra Pradesh
Authors: Das Sankha , Shukla Devasheesh , Bhattacharjee Santanu , Mitra Sumit Kumar
Published: June 2015

The Nellore Schist Belt (NSB) is a curvilinear Archaean schist belt, approximately 350 km long and 8-50 km wide. The Nellore Schist Belt is considered to be equivalent of the Sargur Group with a protolith age of 3.3-2.5Ga. Stratigraphically NSB is classified as the upper western Udayagiri Domain (dominated by metasediments) and lower eastern Vinjamuru Domain (dominated by metabasalts). Metabasalts of Vinjamuru Domain have been dated as of 2654 ± 100 Ma age, but so far no dates are available for the Udayagiri Domain. During recent mapping, in the central western part of NSB, west of Pamuru town, in a metapellite of Udayagiri Domain (consisting mainly of quartz, muscovite, paragonite, Spessartine garnet, chlorite, chloritoid and magnetite as accessory mineral) four small grains of Xenotime has been found, among which three grains have been dated. Xenotime is a rare earth phosphate mineral whose major is Yttrium orthophosphate (YPO4). Xenotime preferentially incorporates smaller HREEs and Yitrium. Xenotime has high U content and very low initial Pb concentration, so it is ideal for U-Pb geochronology. Xenotime can be of different origin such as detrital, diagenetic, hydrothermal and metamorphic. The age calculated from xenotime with the Age Quant of SX-Peak sight software gives an average age of1921±120 Ma. This age matches well with CHIME age of 1929±130 Ma of xenotime. All the textural and geochemical characteristics of the grains suggest that the xenotime is of retrograde metamorphic origin which occurs after D1 phase of deformation, hence constraining the upper age limit of the Udayagiri Domain to be 1929±130 Ma.
New Gravity Bases in Jabera-Damoh Vindhyan Basin, Central India
Authors: Srivastava Ravi Prakash , Vedanti Nimisha , Dimri V. P.
Published: June 2015

To map the geological features of long debated Jabera-Damoh region of Vindhyan basin, a detailed gravity survey was carried out. In this survey, gravity observations were taken at 1500 stations and new gravity bases were established at 40 locations. This paper provides information about the acquired gravity data along with absolute gravity values calculated at gravity bases for the use of general scientific community. All the necessary gravity data correction steps are given with formula except terrain and geoid corrections as they were not applicable to the data used in the present study. This will be very helpful for the students as well as young researchers, who want to venture in this field. Elevation, Bouguer and free air anomaly maps are also prepared, which may be useful for future planning. The Bouguer anomaly map of this region has brought several interesting features like (1) possible extension of Jabera-Damoh basin further south beyond NSL and (2) possibility of occurrence of Kimberlite pipes below Mahakoshal group of rocks, situated Northwest of Damoh towards Panna diamond field. Researchers who are interested in raw gravity digital data for the future research work can approach Director, NGRI, Hyderabad.
Geochemistry of Ukhrul Limestone of Assam-Arakan Subduction Basin, Manipur, Northeast India
Authors: Devi Khumukcham Radhapiyari , Duarah Bhagawat Pran
Published: June 2015

Geochemical studies of the carbonate rocks of Ukhrul limestone from Hundung and Payoi area of Ukhrul District of Manipur, India have been carried out through investigation of major oxides and trace elements geochemistry to determine their chemical composition, to establish the distribution pattern and mutual relationship of the elements, for chemical classification of the limestones and also to decipher environmental conditions that existed during the time of deposition of the calcareous sediments. The study indicates that the limestones were deposited in open to protected near shore, marginal neritic environment with argillaceous sediment flux derived from a granitic continental crust. Protected basin existed partly in Paoyi area. Presence of marine gastropods and foraminifera fossils and higher concentration of strontium in the studied carbonate rocks suggest relatively shallow marine environment of deposition during the Eocene sedimentation.
Are gluten-free foods healthier than non-gluten-free foods? An evaluation of supermarket products in Australia
Authors: Wu Jason H. Y. , Neal Bruce , Trevena Helen , Crino Michelle , Stuart-Smith Wendy , Faulkner-Hogg Kim , Yu Louie Jimmy Chun , Dunford Elizabeth
Published: June 2015

Despite tremendous growth in the consumption of gluten-free (GF) foods, there is a lack of evaluation of their nutritional profile and how they compare with non-GF foods. The present study evaluated the nutritional quality of GF and non-GF foods in core food groups, and a wide range of discretionary products in Australian supermarkets. Nutritional information on the Nutrition Information Panel was systematically obtained from all packaged foods at four large supermarkets in Sydney, Australia in 2013. Food products were classified as GF if a GF declaration appeared anywhere on the product packaging, or non-GF if they contained gluten, wheat, rye, triticale, barley, oats or spelt. The primary outcome was the ‘Health Star Rating’ (HSR: lowest score 0·5; optimal score 5), a nutrient profiling scheme endorsed by the Australian Government. Differences in the content of individual nutrients were explored in secondary analyses. A total of 3213 food products across ten food categories were included. On average, GF plain dry pasta scored nearly 0·5 stars less (P< 0·001) compared with non-GF products; however, there were no significant differences in the mean HSR for breads or ready-to-eat breakfast cereals (P≥ 0·42 for both). Relative to non-GF foods, GF products had consistently lower average protein content across all the three core food groups, in particular for pasta and breads (52 and 32 % less, P< 0·001 for both). A substantial proportion of foods in discretionary categories carried GF labels (e.g. 87 % of processed meats), and the average HSR of GF discretionary foods were not systematically superior to those of non-GF products. The consumption of GF products is unlikely to confer health benefits, unless there is clear evidence of gluten intolerance.
Association of a genetic marker at the bovine Janus kinase 2 locus (JAK2/RsaI) with milk production traits of four cattle breeds
Authors: Szewczuk Małgorzata
Published: June 2015

In addition to the main components of the somatotrophic axis (GH/GHR/IGF-I/IGF-IR), great importance in the control of growth and development is also attached to the Janus kinase 2 (JAK2) pathway. Induced by the GH/GHR complex, JAK2 activates signal transducer and activator of transcription 5 (STAT5), and in consequence, may be involved in the regulation of expression of insulin-like growth factor I (IGF-I) in the mammary gland. Silent mutation (rs110298451) has been identified within exon 20 using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). A total of 904 individuals of four dairy or dual-purpose breeds (Polish Holstein-Friesian, Montbeliarde, Simmental and Jersey) were genotyped. A genotypic imbalance in the populations was observed. In the case of dual-purpose breeds (Montbeliarde and Simmental), the frequencies of both alleles were almost equal. In contrary, the JAK2G allele was predominant in the Polish Holstein-Friesian breed while JAK2A allele in Jersey. A pronounced relationship between JAK2/RsaI polymorphism and milk production traits was found where, irrespective of breed and lactation order, the GG genotype was significantly associated with higher milk, protein and fat yields, as compared to the AA genotype. Heterozygous individuals were generally characterised by intermediate values of the analysed milk traits. It can be argued that the JAK2 gene polymorphism is a potential marker for milk production traits. However, due to the fact that rs110298451 SNP does not directly affect amino acid sequence, other association studies involving missense mutation should also be performed.
Second-hand smoke and the risk of tuberculosis: a systematic review and a meta-analysis
Authors: DOGAR O. F. , PILLAI N. , SAFDAR N. , SHAH S. K. , ZAHID R. , SIDDIQI K.
Published: June 2015

There is limited evidence and lack of consensus whether second-hand smoke (SHS) increases risk of tuberculosis (TB), which has substantial implications for unrestricted smoking indoors and TB control policies. We aimed to establish the association between SHS and the risk of acquiring and worsening of TB in non-smokers. We identified 428 articles in the initial search and 12 comparative epidemiological studies met our inclusion criteria. Exposure to SHS was found to have a higher risk of TB infection [risk ratio (RR) 1·19, 95% confidence interval (CI) 0·90–1·57] compared to non-exposure; however, this did not reach statistical significance. There was marked variability (I2= 74%,P= 0·0008) between studies’ results, which could be explained by the differences in the diagnostic criteria used. Exposure to SHS was found to be statistically significantly associated (RR 1·59, 95% CI 1·11–2·27) with the risk of TB disease. There was significant heterogeneity (I2= 77%,P= 0·0006) between studies’ results, which was sourced to the internal characteristics of the studies rather than combining different study designs. We did not find any studies for SHS and TB treatment-related outcomes. Thus, we conclude that SHS exposure may increase the risk of acquiring TB infection and progression to TB disease; however, the evidence remains scanty and weak.
Phylogenetic analysis of Bunyamwera and Ngari viruses (family Bunyaviridae, genus Orthobunyavirus) isolated in Kenya
Authors: ODHIAMBO C. , VENTER M. , LWANDE O. , SWANEPOEL R. , SANG R.
Published: June 2015

Orthobunyaviruses, tri-segmented, negative-sense RNA viruses, have long been associated with mild to severe human disease in Africa, but not haemorrhagic fever. However, during a Rift Valley fever outbreak in East Africa in 1997–1998, Ngari virus was isolated from two patients and antibody detected in several others with haemorrhagic fever. The isolates were used to identify Ngari virus as a natural Orthobunyavirus reassortant. Despite their potential to reassort and cause severe human disease, characterization of orthobunyaviruses is hampered by paucity of genetic sequences. Our objective was to obtain complete gene sequences of two Bunyamwera virus and three Ngari virus isolates from recent surveys in Kenya and to determine their phylogenetic positioning within the Bunyamwera serogroup. Newly sequenced Kenyan Bunyamwera virus isolates clustered closest to a Bunyamwera virus isolate from the same locality and a Central African Republic isolate indicating that similar strains may be circulating regionally. Recent Kenyan Ngari isolates were closest to the Ngari isolates associated with the 1997–1998 haemorrhagic fever outbreak. We observed a temporal/geographical relationship among Ngari isolates in all three gene segments suggesting a geographical/temporal association with genetic diversity. These sequences in addition to earlier sequences can be used for future analyses of this neglected but potentially deadly group of viruses.
Salmonella Typhimurium outbreak associated with a contaminated food container in a school in Sichuan Province, China
Authors: LIU L. G. , ZHOU X. Y. , LAN Z. , LI L. , LI Z. , CHEN W. , WANG J. Y. , ZHANG L. J.
Published: June 2015

On 13 June 2013, a fever and diarrhoea outbreak occurred in a boarding school in Sichuan Province. We conducted a field investigation and compared food exposure of 81 case students and 104 control students (years 7 and 8) in order to identify the source of infection. There were 401 cases identified (399 students and two cooks). The attack rates were 23–46% in nursery, primary, and secondary schools, but 0% in the high school. Eighty-five percent of case students, consumed cowpea salad compared to 60% of control students at lunch on 12 June (odds ratio 3·1, 95% confidence interval 1·3–7·8). The cowpeas were stored at room temperature for 3 h in a bucket previously used to store raw ingredients. The bucket was cleaned using water without a disinfectant. There were two buckets of cowpea, one for the high-school students and another for the other students. This Salmonella outbreak was likely caused by the cowpea salad due to cross-contamination via a storage bucket.
Converting perennial legumes to organic cropland without tillage
Authors: Anderson Randy L.
Published: June 2015

Organic producers are interested in developing a no-till system for crop production. In this study, we examined management tactics to convert perennial legumes to annual crops without tillage. Our hypothesis was that reducing carbohydrate production in the fall by mowing would favor winterkill. Mowing treatments were imposed in the fall of the third year of alfalfa or red clover, and corn planted in year 4. The conventional practice of tillage to convert legumes to cropland was also included as a treatment. Mowing in autumn reduced red clover biomass 93% compared with alfalfa when measured 3 weeks after corn planting (WAP). Red clover biomass was still 75% less than alfalfa 6 WAP. Fall mowing suppressed red clover sufficiently to enable corn seedlings to establish, but corn seedlings did not survive in mowed alfalfa due to alfalfa competition. Corn grain yield following red clover was similar in the mowed and tilled treatments when weeds were present. Late season clover and weed growth reduced corn yields 46% compared with weed-free corn. Weed emergence in corn was three times higher after tillage compared with the mowed treatment. Converting red clover to annual crops with fall mowing will support a no-till system for organic farming.
Total efficiency enhancement of X-band compact choke horn antenna with circular polarization and isoflux pattern
Authors: Arnaud Eric , Duchesne Luc , Elis Kevin , Fouany Jamil , Monediere Thierry , Thevenot Marc
Published: June 2015

This paper presents a solution to reduce the feed complexity and to improve the total efficiency of X-band compact choke horn antenna with circular polarization and isoflux pattern. This kind of antenna had been designed before by our laboratory for nanosatellite applications, but it required a 4-way divider with phase shifter which generates the insertion losses and therefore a lower realized gain (RG). Among several feeds, a uniform circular helix antenna has been used here, which produces a satisfying feed without too much damage for the axial ratio (AR) and the isoflux pattern over a 400 MHz radiation bandwidth (8.0–8.4 GHz). Theoretical and experimental results show an AR lower than 5 dB and a RG higher than 0 dB at the limit of coverage, i.e. 65° whatever the azimuth angle (φ).
Creole cattle from northwestern Mexico has high genetic diversity in the locus DRB3.2
Authors: Fernández I.G. , Leyva-Baca I. , Rodríguez-Almeida F. , Ulloa-Arvizu R. , Ríos-Ramírez J.G. , Gayosso-Vázquez A. , Alonso-Morales R.A.
Published: June 2015

The objective of this study was to determine the genetic diversity of creole cattle in northwestern Mexico using the BoLA-DRB3.2 locus of the Major Histocompatibility Complex (MHC). A total of 56 creole cattle were sampled from five communities; in the state of Chihuahua (Cerocahui, Guadalupe y Calvo and Cuauhtémoc) and in the state of Baja California Sur (La Paz and Mulegé). The BoLA-DRB3.2 locus was genotyped by PCR-RFLP assay. Thirty-nine alleles were identified, out of which 14 had not been previously reported. The average level of inbreeding in all populations analyzed wasFIS= 0.09 (P< 0.0001), but only two populations (Cerocahui and Guadalupe y Calvo) showed an excess of homozygotes (P< 0.05). The breed differentiation in all populations studied wasFSC= 0.068 (P< 0.0001). The smallest genetic distance was between La Paz and Mulegé (0.022); but Mulegé presented smaller distances (0.028–0.053) with the populations of La Paz (0.071–0.083) and with Chihuahua. Baja California Sur populations are grouped in a separate branch than Chihuahua populations. We conclude that creole cattle from Baja California Sur and Chihuahua show high genetic diversity in the locus BoLA-DRB3.2.
Effekte eines Therapiebegleithundes auf Patienten im stationären Drogenentzug
Authors: Urban Sabine , Dehn Lorenz B. , Zillmer Björn , Driessen Martin , Beblo Thomas
Published: June 2015

Fragestellung: Positive Effekte tiergestützter Therapie (TGT) auf Patienten sind belegt. Die vorliegende Studie geht der Frage nach, ob auch Substanzabhängige im stationären Drogenentzug von TGT profitieren und sich unmittelbare Effekte auf die emotionale Befindlichkeit und das subjektive Craving zeigen lassen. Methode: 26 Patienten (ICD-10: F11.2; F12.2, Alter:18 – 65 Jahre) wurden in der randomisiert-kontrollierten Studie im Cross-Over-Design untersucht und in Gruppe A und B aufgeteilt. Gruppe A erhielt zuerst das Interventionsangebot (Spaziergänge mit Hund) und dann das Kontrollangebot (Spaziergänge ohne Hund), bei Gruppe B wurde umgekehrt verfahren. Vor und nach jeder Intervention wurden die emotionale Befindlichkeit und das Craving der Probanden erfasst. Außerdem wurde über den Studienzeitraum hinweg die globale psychopathologische Symptombelastung der Patienten ermittelt. Ergebnisse: Es konnten signifikant stärkere prä-/post-Veränderungen unter der Interventionsbedingung mit Hund im Vergleich zu ohne Hund auf die emotionale Befindlichkeit und eine tendenziell signifikant ausgeprägtere Verringerung des Cravings nach der Intervention mit Hund aufgezeigt werden. Im Studienverlauf reduzierte sich die globale psychopathologische Symptombelastung deutlich, hier fanden sich keine hundespezifischen Effekte. Schlussfolgerung: Es ergeben sich erste Hinweise darauf, dass substanzabhängige Patienten im akutpsychiatrischen Drogenentzug kurzfristig von TGT mit einem Hund profitieren.
Internationale Aspekte der Verankerung inklusiver Unterrichtskonzepte
Authors: Häßler Frank , Burgert Michael , Fegert Jörg Michael , Chodan Wencke
Published: June 2015

Der Begriff Inklusion (= Einschluss, Dazugehörigkeit) wird geradezu synonym für die gemeinsame Beschulung von Kindern mit und ohne Behinderung des Lernens, der Sprache, des Körpers und/oder der Seele verwendet. Der vorliegende Artikel behandelt den Stand inklusiver Beschulung in Deutschland sowie internationale Entwicklungen wie die Salamanca-Erklärung der UNESCO, den «Individuals with Disabilities Act» (IDEA) der USA sowie den Stand und ausgewählte Fortschritte im europäischen Raum, insbesondere in Großbritannien, Österreich und Russland. Obwohl aus politischer Sicht die Entscheidung für die Inklusion unumkehrbar anmutet, scheint es bisher keine Einigung über den Weg und Zeitrahmen zur Umsetzung zu geben. So liegt der durchschnittliche Anteil der Schüler mit einem sonderpädagogischen Förderbedarf, die in Regelklassen an Regelschulen unterrichtet werden, bei nur 28.2 % (Grundgesamtheit: alle Schüler mit ausgewiesenem Förderbedarf in Deutschland). Hierfür werden Ursachen analysiert und diskutiert. Daneben erscheint als die vorrangige Frage die nach dem Nutzen für die Betroffenen, da die Perspektive der Betroffenen der Maßstab dafür sein sollte, ob Inklusion als gelungen angesehen wird. Diese Frage kann mit hoher Wahrscheinlichkeit nur bezogen auf einzelne Subgruppen von Behinderten valide beantwortet werden kann. Hier besteht noch erheblicher Forschungsbedarf.
The Prediction of Problem-Solving Assessed Via	Microworlds
Authors: Greiff Samuel , Krkovic Katarina , Hautamäki Jarkko
Published: June 2015

Abstract. In this study, we explored the network of relations between fluid reasoning, working memory, and the two dimensions of complex problem solving, rule knowledge and rule application. In doing so, we replicated the recent study by Bühner, Kröner, and Ziegler (2008) and the structural relations investigated therein [ Bühner, Kröner, & Ziegler, (2008) . Working memory, visual-spatial intelligence and their relationship to problem-solving. Intelligence, 36, 672–680]. However, in the present study, we used different assessment instruments by employing assessments of figural, numerical, and verbal fluid reasoning, an assessment of numerical working memory, and a complex problem solving assessment using the MicroDYN approach. In a sample of N = 2,029 Finnish sixth-grade students of which 328 students took the numerical working memory assessment, the findings diverged substantially from the results reported by Bühner et al. Importantly, in the present study, fluid reasoning was the main source of variation for rule knowledge and rule application, and working memory contributed only a little added value. Albeit generally in line with previously conducted research on the relation between complex problem solving and other cognitive abilities, these findings directly contrast the results of Bühner et al. (2008) who reported that only working memory was a source of variation in complex problem solving, whereas fluid reasoning was not. Explanations for the different patterns of results are sought, and implications for the use of assessment instruments and for research on interindividual differences in complex problem solving are discussed.
Incremental Validity of the Trait Emotional Intelligence	Questionnaire-Adolescent Short Form (TEIQue-ASF)
Authors: Siegling Alex B. , Vesely Ashley K. , Saklofske Donald H. , Frederickson Norah , Petrides K. V.
Published: June 2015

Abstract. This study examined the incremental validity of the adolescent short form of the Trait Emotional Questionnaire (TEIQue-ASF) in two European secondary-school samples. The TEIQue-ASF was administered as a predictor of socioemotional or academic achievement criteria, along with measures of coping strategies or cognitive ability, respectively. In Dutch high school students (N = 282), the TEIQue-ASF explained variance in all socioemotional criteria, controlling for coping strategies and demographics. In a sample of British preadolescents, the measure showed incremental contributions to academic achievement in the core areas (English, math, and science) of the English curriculum, controlling for cognitive ability subscales and gender (N = 357–491). Implications for the validity and applied utility of the TEIQue-ASF are discussed.
Impact of Differential-Item-Functioning on the Personal	Epistemological Beliefs for Senior High School Students
Authors: Syu Jia-Jia , Zhang Liang-Cheng
Published: June 2015

Abstract. The purpose of this study is to investigate whether the expression of items used to examine personal epistemological beliefs could affect the probabilities of response for compared groups and research outcomes. Differential-item-functioning (DIF) analysis on school types and location of school according to the Rasch model was performed in this study. Nonacademically inclined school students (n = 212) and academically inclined school students (n = 197) were selected to complete the questionnaire. The questionnaire consisted of three dimensions of beliefs about knowing and two dimensions of beliefs about learning. The results of the DIF analysis suggested that the items in the dimensions about knowing favor academically inclined students and students from schools located in the northern areas of Taiwan. The items in the learning dimensions favor nonacademically inclined students and students from schools located in the southern areas of Taiwan. The group comparisons were different between the scale that included the DIF items and the scale that excluded the DIF items. The discussion addresses the value of the precise detections for inappropriate items and the effect of the academic achievement on completing the survey.
Anxiety Sensitivity or Interoceptive Sensitivity
Authors: Norton Peter J. , Sears Edwards Katharine
Published: June 2015

Abstract. The construct of anxiety sensitivity (AS) – the fear of anxiety-related symptoms – has been highly influential in current conceptualizations of anxiety disorders in general, and panic disorder specifically. However, given documented associations between AS and both non-anxiety psychological disorders as well as medical/health conditions, the extent to which measures of AS are assessing a specific fear or anxiety symptoms versus a broader fear of interoceptive or bodily sensations is unclear. Confirmatory factor analysis of data from 373 participants failed to suggest whether fears of anxiety-related symptoms were factorially distinct from fears of non-anxiety-related bodily sensations, although analyses indicated that while fears of anxiety-related symptoms were more closely associated with panic disorder severity than were fears of non-anxiety-related symptoms, both were similarly and strongly associated with hypochondriacal fears. Implications for the construct of AS, and the broader construct of somatic fears, are discussed.
Embodiment of Narrative Engagement
Authors: Sukalla Freya , Bilandzic Helena , Bolls Paul D. , Busselle Rick W.
Published: June 2015

Abstract. This study investigated the validity of the narrative engagement scale ( Busselle & Bilandzic, 2009 ) by grounding the dimensions of the scale in relationships between self-reported narrative engagement and embodied mental processes occurring during exposure. Psychophysiological measures were used to observe real-time variation in mental processes activated when individuals viewed narrative content that was manipulated in two fundamental content characteristics: cohesion and emotional content. The results of a 2 (low vs. high cohesion) × 2 (low vs. high emotional content) × 3 (video clips) mixed model repeated measures experiment showed consistent influences of cohesion and emotional content on self-reported narrative engagement as well as psychophysiological indicators (heart rate, skin conductance, corrugator activity). Confirming the hypotheses, self-reported attentional focus was related to lower levels of heart rate, while self-reported emotional engagement was positively related to corrugator activity. Both attentional focus and emotional engagement were related to increases of skin conductance levels over time. The results support the validity of the dimensional concept of narrative engagement and open further avenues for clarifying mechanisms of narrative persuasion.
Going Above and Beyond: Exemplar Diversity Training in Pediatric Psychology
Authors: Thurston Idia B. , Gray Wendy N. , Pulgaron Elizabeth R.
Published: June 2015

Diversity and health disparities have been highlighted as 1 of the 10 core crosscutting knowledge competencies for pediatric psychology training. Specifics about the actual implementation and integration of diversity training across various types of pediatric psychology programs are largely unknown. We surveyed program directors of graduate and predoctoral internship programs listed on the Society of Pediatric Psychology website ( N = 103) about their diversity training experiences that went above and beyond what is typically required (e.g., graduate courses, continuing education). We received responses from 23 programs; 14 of these programs reported having expanded diversity training primarily at the readiness for practice ( n = 15) level, followed by readiness for practicum ( n = 5) and readiness for graduate school ( n = 2) levels. Seven programs had diversity training that spanned more than 1 training level. We provided in-depth descriptions of exemplar diversity training at 5 programs spanning multiple training levels. Institutions aiming to integrate diversity programming into their training, with the goal of meeting recommended guidelines, can use this article as a practical guide. Future studies exploring the impact of integrated diversity training and impact on students at varying developmental levels are needed.
Developing Pediatric Psychology Science and Application Competencies in Doctoral-Level Graduate Programs: Timing and Sequencing of Training at the University of Georgia
Authors: Eaton Cyd K. , Blount Ronald L.
Published: June 2015

Pediatric psychology competencies were recently defined. There remains discussion about the timing of specialization and sequencing of training experiences in doctoral programs to optimally develop these competencies. A developmental model of training within the Science and Application clusters ( Palermo, Janicke, et al., 2014 ) is presented with reference to sequencing of specific training experiences, timing of specialization, and outcome data over the past 5 years for individuals completing the doctoral program at the University of Georgia. This training model involves a progression from developing broad-based, clinical psychology competencies in early training to increased focus on pediatric psychology competencies over time.
Decarbonylative organoboron cross-coupling of esters by nickel catalysis
Authors: Muto Kei , Yamaguchi Junichiro , Musaev Djamaladdin G. , Itami Kenichiro
Published: June 2015

The Suzuki–Miyaura cross-coupling is a metal-catalysed reaction in which boron-based nucleophiles and halide-based electrophiles are reacted to form a single molecule. This is one of the most reliable tools in synthetic chemistry, and is extensively used in the synthesis of pharmaceuticals, agrochemicals and organic materials. Herein, we report a significant advance in the choice of electrophilic coupling partner in this reaction. With a user-friendly and inexpensive nickel catalyst, a range of phenyl esters of aromatic, heteroaromatic and aliphatic carboxylic acids react with boronic acids in a decarbonylative manner. Overall, phenyl ester moieties function as leaving groups. Theoretical calculations uncovered key mechanistic features of this unusual decarbonylative coupling. Since extraordinary numbers of ester-containing molecules are available both commercially and synthetically, this new ‘ester’ cross-coupling should find significant use in synthetic chemistry as an alternative to the standard halide-based Suzuki–Miyaura coupling.
Investigation of multipotent postnatal stem cells from human maxillary sinus membrane
Authors: Guo JunBing , Weng JunQuan , Rong Qiong , Zhang Xing , Zhu ShuangXi , Huang DaiYing , Li Xiang , Chen Song Ling
Published: June 2015

Maxillary sinus membrane (MSM) elevation is a common surgical technique for increasing bone height in the posterior maxilla prior to dental implant placement. However, the biological nature of bone regeneration in MSM remains largely unidentified. In this study, MSM tissue was obtained from 16 individuals during orthognathic surgery and used to isolate MSM stem cells (MSMSCs) by single-colony selection and STRO-1 cell sorting. The cell characteristics in terms of colony-forming ability, cell surface antigens, multi-differentiation potential and in vivo implantation were all evaluated. It was found that MSMSCs were of mesenchymal origin and positive for mesenchymal stem cell (MSC) markers such as STRO-1, CD146, CD29 and CD44; furthermore, under defined culture conditions, MSMSCs were able to form mineral deposits and differentiate into adipocytes and chondrocytes. When transplanted into immunocompromised rodents, MSMSCs showed the capacity to generate bone-like tissue and, importantly, maintain their MSC characteristics after in vivo implantation. These findings provide cellular and molecular evidence that MSM contains stem cells that show functional potential in bone regeneration for dental implant.
Entropic Uncertainty Relation and Information Exclusion Relation for multiple measurements in the presence of quantum memory
Authors: Zhang Jun , Zhang Yang , Yu Chang-shui
Published: June 2015

The Heisenberg uncertainty principle shows that no one can specify the values of the non-commuting canonically conjugated variables simultaneously. However, the uncertainty relation is usually applied to two incompatible measurements. We present tighter bounds on both entropic uncertainty relation and information exclusion relation for multiple measurements in the presence of quantum memory. As applications, three incompatible measurements on Werner state and Horodecki’s bound entangled state are investigated in details.
Osmotin attenuates amyloid beta-induced memory impairment, tau phosphorylation and neurodegeneration in the mouse hippocampus
Authors: Ali Tahir , Yoon Gwang Ho , Shah Shahid Ali , Lee Hae Young , Kim Myeong Ok
Published: June 2015

The pathological hallmarks of Alzheimer’s disease (AD) include amyloid beta (Aβ) accumulation, neurofibrillary tangle formation, synaptic dysfunction and neuronal loss. In this study, we investigated the neuroprotection of novel osmotin, a plant protein extracted from Nicotiana tabacum that has been considered to be a homolog of mammalian adiponectin. Here, we observed that treatment with osmotin (15 μg/g, intraperitoneally, 4 hr) at 3 and 40 days post-intracerebroventricular injection of Aβ1-42 significantly ameliorated Aβ1-42-induced memory impairment in mice. These results revealed that osmotin reverses Aβ1-42 injection-induced synaptic deficits, Aβ accumulation and BACE-1 expression. Treatment with osmotin also alleviated the Aβ1-42-induced hyperphosphorylation of the tau protein at serine 413 through the regulation of the aberrant phosphorylation of p-PI3K, p-Akt (serine 473) and p-GSK3β (serine 9). Moreover, our western blots and immunohistochemical results indicated that osmotin prevented Aβ1-42-induced apoptosis and neurodegeneration in the Aβ1-42-treated mice. Furthermore, osmotin attenuated Aβ1-42-induced neurotoxicity in vitro.

To our knowledge, this study is the first to investigate the neuroprotective effect of a novel osmotin against Aβ1-42-induced neurotoxicity. Our results demonstrated that this ubiquitous plant protein could potentially serve as a novel, promising and accessible neuroprotective agent against progressive neurodegenerative diseases such as AD.
Direct measurement on the geometric phase of a double quantum dot qubit via quantum point contact device
Authors: Liu Bao , Zhang Feng-Yang , Song Jie , Song He-Shan
Published: June 2015

We propose a direct measurement scheme to read out the geometric phase of a coupled double quantum dot system via a quantum point contact(QPC) device. An effective expression of the geometric phase has been derived, which relates the geometric phase of the double quantum dot qubit to the current through QPC device. All the parameters in our expression are measurable or tunable in experiment. Moreover, since the measurement process affects the state of the qubit slightly, the geometric phase can be protected. The feasibility of the scheme has been analyzed. Further, as an example, we simulate the geometrical phase of a qubit when the QPC device is replaced by a single electron transistor(SET).
Dispersive growth and laser-induced rippling of large-area singlelayer MoS2 nanosheets by CVD on c-plane sapphire substrate
Authors: Liu Hongfei , Chi Dongzhi
Published: June 2015

Vapor-phase growth of large-area two-dimensional (2D) MoS2nanosheets via reactions of sulfur with MoO3precursors vaporized and transferred from powder sources onto a target substrate has been rapidly progressing. Recent studies revealed that the growth yield of high quality singlelayer (SL) MoS2is essentially controlled by quite a few parameters including the temperature, the pressure, the amount/weight of loaded source precursors and the cleanup of old precursors. Here, we report a dispersive growth method where a shadow mask is encapsulated on the substrate to ‘indirectly’ supply the source precursors onto the laterally advancing growth front at elevated temperatures. With this method, we have grown large-area (up to millimeters) SL-MoS2nanosheets with a collective in-plane orientation on c-plane sapphire substrates. Regular ripples (~1 nm in height and ~50 nm in period) have been induced by laser scanning into the SL-MoS2nanosheets. The MoS2ripples easily initiate at the grain boundaries and extend along the atomic steps of the substrate. Such laser-induced ripple structures can be fundamental materials for studying their effects, which have been predicted to be significant but hitherto not evidenced, on the electronic, mechanical and transport properties of SL-MoS2.
Stimulation of EphB2 attenuates tau phosphorylation through PI3K/Akt-mediated inactivation of glycogen synthase kinase-3β
Authors: Jiang Jun , Wang Zhi-Hao , Qu Min , Gao Di , Liu Xiu-Ping , Zhu Ling-Qiang , Wang Jian-Zhi
Published: June 2015

Abnormal tau hyperphosphorylation is an early pathological marker of Alzheimer’s disease (AD), however, the upstream factors that regulate tau phosphorylation are not illustrated and there is no efficient strategy to arrest tau hyperphosphorylation. Here, we find that activation of endogenous EphB2 receptor by ligand stimulation (ephrinB1/Fc) or by ectopic expression of EphB2 plus the ligand stimulation induces a remarkable tau dephosphorylation at multiple AD-associated sites in SK-N-SH cells and human embryonic kidney cells that stably express human tau (HEK293-tau). In cultured hippocampal neurons and the hippocampus of human tau transgenic mice, dephosphorylation of tau proteins was also detected by stimulation of EphB2 receptor. EphB2 activation inhibits glycogen synthase kinase-3β (GSK-3β), a crucial tau kinase and activates phosphatidylinositol-3-kinase (PI3K)/Akt both in vitro and in vivo, whereas simultaneous inhibition of PI3K or upregulation of GSK-3β abolishes the EphB2 stimulation-induced tau dephosphorylation. Finally, we confirm that ephrinB1/Fc treatment induces tyrosine phosphorylation (activation) of EphB2, while deletion of the tyrosine kinase domain (VM) of EphB2 eliminates the receptor stimulation-induced GSK-3β inhibition and tau dephosphorylation. We conclude that activation of EphB2 receptor kinase arrests tau hyperphosphorylation through PI3K-/Akt-mediated GSK-3β inhibition. Our data provide a novel membranous target to antagonize AD-like tau pathology.