bluuebunny/crossref_metadata_2025 huggingface dataset:
Multi-body Dynamic Modelling and Error Analysis of Planar Flexible Multilink Mechanism Considering Clearance and Thermal-mechanical Coupling Effect of the Crankshaft-bearing Structure
Authors: Long Hongfan , Han Zhao , Jiang Shuyun , Zheng Enlai , Zhang Yongnian , Zhu Yue , Wang Yongjian
Published: September 2021

In order to study the dynamic position accuracy of bottom dead point (BDP) for multilink high-speed precision presses (MHSPPs), it’s essential to develop a dynamic model of planar multilink mechanism with clearance and spindle-bearing structure. Traditional models always neglect the effect of thermal characteristics of spindle-bearing structure, which reduces the prediction accuracy of dynamic model for multilink transmission mechanisms. To overcome the shortcomings of the previous models, a thermal network model (TNM) of the crankshaft-bearing system is established firstly considering the effects of thermal contact resistance and variable stiffness of bearing concerning the temperature rise. Then, dynamic model of the crankshaft-bearing system is built through the finite element method, which includes rigid disk, Timoshenko beam and quasi-statics model of ACBB. On this basis, an improved dynamic model of planar flexible multilink mechanism with clearance considering the thermal-mechanical coupling effect of the crankshaft-bearing structure is developed and the corresponding dynamic error dimension chain between slider and crankshaft is constructed in this work. Compared to the simulation from traditional models, the simulated slider’s BPD position error from the improved model agrees better with experimental data, which verifies the correctness of the proposed model. It’s demonstrated that the punching force and thermally induced variable stiffness of bearing lead to a significant increase of slider’s BDP position error, which reduces the machining precision of MHSPP. Furthermore, the influence of crankshaft speed, contact angle of bearing and clearance size on the slider’s BDP position error is also investigated.
NIMA-Related Kinase 6 as an Effective Target Inhibits the Hepatocarcinogenesis and Progression of Hepatocellular Carcinoma
Authors: Zhang Hao , Li Bo
Published: September 2021

BackgroundNever in Mitosis Gene A-Related Kinase (NEK), a member of the cell cycle-dependent protein kinase, encodes a serine/threonine protein kinase involved in mitosis of the G2-M transition period. Eleven NEKs have been identified, and NEK6 is one of them. It has been confirmed that NEK6 is over-expressed in some tumor cell lines. The following study aims to explore the expression of NEK6 in hepatocellular carcinoma (HCC) and the correlation between NEK6 expression and clinical features.MethodsLiver tissues of 79 HCC patients and other patients were obtained during various liver surgeries. Total RNA from these tissue samples was extracted and QPCR was adopted to detect positive expression of NEK6. The correlation between NEK6 expression and the clinical characteristics of HCC was analyzed. The expression of NEK6 in different cell lines (LO-2, HepG2, Li-7, Huh-7, and BEL-7402) was quantified via QPCR. Scratch assay, Transwell assay, and tumor-formation assay in nude mice were used to evaluate the effects of NEK6 on the HCC progression in vitro and in vivo.ResultThe expression of NEK6 was up-regulated in HCC tissue compared with other tissues. The proportion of hepatitis B virus infection in the Nek6 Overexpression group was higher than the Control group (P=0.045). The multiple tumors and bigger tumors (>5 cm) seemed more common in the NEK6 overexpression group (P=0.018, and P=0.037, respectively). Further analysis showed that the overexpression of NEK6 was correlated with hepatitis B virus infection and tumor diameter (P=0.045; P=0.038). The 3-year disease-free survival (DFS) and overall survival (OS) of patients in the NEK6 overexpression group were 14.1% and 33.4%, which were worse than the control group. Tumor size over 5 cm and portal vein invasion were risk factors for both DFS and OS. Nek6 overexpression did not seem to affect the prognosis as a risk factor. Among the human cell lines, the expression of NEK6 was higher in Li-7 cells and HepG2 cells. The migration and invasion capabilities of Li-7 and HepG2 cells were suppressed when the NEK6 expression was down-regulated. The xenograft tumor weight was signiﬁcantly lighter in the shNEK6 group (P < 0.05). ConclusionThe results from the study demonstrated that the expression level of NEK6 was up-regulated in HCC and correlated with the HCC progression, suggesting it might be a clinically valuable biomarker and serve as a potential therapeutic target for treating HCC.
Full reconstruction of simplicial complexes from binary time-series data
Authors: Wang Huan , Ma Chuang , Chen Han-Shuang , Lai Ying-Cheng , Zhang Hai-Feng
Published: September 2021

Previous efforts on data-based reconstruction focused on complex networks with pairwise or two-body interactions. There is a growing interest in networks with high-order or many-body interactions, raising the need to reconstruct such networks based on observational data. We develop a general framework combining statistical inference and expectation maximization to fully reconstruct 2-simplicial complexes with two- and three-body interactions based on binary time-series data from social contagion dynamics. We further articulate a two-step scheme to improve the reconstruction accuracy while significantly reducing the computational load. Through synthetic and real-world 2-simplicial complexes, we validate the framework by showing that all the connections can be faithfully identified and the full topology of the 2-simplicial complexes can be inferred. The effects of noisy data or stochastic disturbance are studied, demonstrating the robustness of the proposed framework.
MiR-574-5P, miR-1827, And miR-4429 As Potential Biomarkers For Schizophrenia
Authors: Davarinejad Omran , Najafi Sajad , Zhaleh Hossein , Golmohammadi Farzaneh , Radmehr Farnaz , Alikhani Mostafa , Moghadam Reza Heidari , Rahmati Yazdan
Published: September 2021

Schizophrenia is a severe chronic debilitating disorder with millions of affected individuals. Lack of a reliable mollecular diagnostic invokes the identification of novel biomarkers. To elucidate the molecular basis of the disease, two mRNA expression arrays including GSE93987 and GSE38485, and one miRNA array, GSE54914, were downloaded from GEO, and meta-analysis was performed for mRNA expression arrays by employment of metaDE package. By WGCNA package, we performed network analysis for both mRNA expression arrays separately. Then, we made protein-protein interaction network for significant modules. Limma package was employed to analyze the miRNA array and dysregulated miRNAs (DEMs) were identified. Using genes of significant modules and DEMs, a mRNA-miRNA network was constructed and hub genes and miRNAs were identified. To confirm the dysregulation of genes, expression values were evaluated by available datasets including GEO series GSE62333, GSE93987, and GSE38485. The ability of the detected hub miRNAs to discriminate Schizophrenia from healthy controls was evaluated by assessing the receiver-operating curve. Finally, by performing Real-Time PCR, the expression level of genes and miRNAs were evaluated in 40 Schizophrenia patients compared with healthy controls. The results confirmed dysregulation of hsa-miR-574-5P, hsa-miR-1827, hsa-miR-4429, CREBRF, ARPP19, TGFBR2, and YWHAZ in blood samples of schizophrenia patients.
Predictive Value of Decreased Serum Estradiol Levels Following Human Chorionic Gonadotropin Trigger For Unexpected Ovulation During In Vitro Fertilization Cycle of Patients With Poor Ovarian Response
Authors: Huang Qianwen , Zhang Qianyu , Sun Li , Tang Ting , Liu Wenjuan , Zhang Jie , Liu Fenghua
Published: September 2021

Background

Unexpected spontaneous ovulation typically occurs in patients with poor ovarian response (POR); however, reliable predictors are lacking. We analyzed explore the predictive value of decreased serum estradiol (E2) levels on the day after human chorionic gonadotropin (hCG) trigger during in vitro fertilization (IVF) cycles.
Methods

We retrospectively analyzed clinical data (n = 978) in IVF cycles between 2017 and 2020. According to decreased ratios of E2 levels (△E2%) between day 1 and day 0 of hCG trigger, patients were divided into: ≤10% (group A), 10–20% (group B), and ≥ 20% (group C). Basic characteristics and laboratory data were compared using analysis of variance or Mann–Whitney U-test. Logistic regression and receiver operating characteristic (ROC) curve analyses were used to assess the relationship between △E2% and spontaneous unexpected ovulation. Fresh embryo transfer cycles in groups A, B, and C were subgrouped as A1, B1, and C1, respectively; clinical outcomes were compared.
Results

Mean E2 and luteinizing hormone (LH) levels, ratio of premature LH peak and high progesterone levels, time interval between hCG trigger and oocyte retrieval, number of follicles ≥ 11 mm in diameter, and dose regimen of gonadotropin among the three groups showed significant differences (P < 0.05). After adjusting for relevant confounders, likelihood ratios of unexpected ovulation in groups B and C were 2.96 (95 % confidence interval [CI]: 0.64–13.70), and 11.74 (95 % CI: 3.09–44.62), respectively, compared with that in group A. The test for trend was significant before and after correction (P for trend < 0.05). On combining premature LH peak (> 10 mIU/mL) or high progesterone level (> 1.0 ng/mL) on the day of hCG, area under ROC curve (AUC) was 0.849 (95 % CI, 0.764–0.934, P < 0.05). However, when we only considered △E2%, AUC was 0.738 (95 % CI. 0.562–0.914, P < 0.05). Rates of embryo implantation, clinical pregnancy, live birth in fresh embryo transfer cycle, and early abortion among the three subgroups did not differ significantly (P > 0.05).
Conclusions

E2 levels on the day after hCG trigger are valuable for predicting unexpected ovulation. However, their decreased levels do not directly affect clinical pregnancy outcomes.
GnRH antagonist weakens endometrial stromal cells growth ability by decreasing c-kit receptor expression
Authors: Xu Ding-Fei , Liu Pei-Pei , Fan Lu , Xie Qi , Zhang Zhi-Qin , Tan Jun , Wu Qiong-Fang , Wang Li-Qun
Published: September 2021

Background
Several surveys have reported that patients treated with gonadotropin-releasing hormone antagonist (GnRH-ant) protocol showed a significantly lower rate of implantation and clinical pregnancy compared to GnRH agonist (GnRH-a) protocol during in vitro fertilization-fresh embryo transfer. Subsequent studies imputed this poor outcome to the negative effects of GnRH-ant on endometrial receptive. However, the mechanisms were not fully understood.
Methods
The clinical data of 2815 patients undergoing fresh embryo transfer in our center were analyzed. Human endometrial stromal cells (ESCs) from healthy women undergoing elective pregnancy termination of a normal pregnancy at 8–10 weeks gestation were treated with GnRH-analogs or imatinib (c-kit receptor inhibitor).
Results
The clinical data showed that the endometrial thickness on HCG Day were significantly lower in GnRH-ant group. Although no difference of embryo quality in these two groups, GnRH-ant group showed remarkably decreased rate of HCG positive, embryo implantation and pregnancy. Moreover, GnRH-ant significantly reduced the proliferation and induced the apoptosis of ESCs. Furthermore, the expression and activation of c-kit receptor, which played pivotal roles during embryo implantation, were observably decreased by GnRH-ant. Inhibiting the activation of c-kit by imatinib remarkably suppressed the proliferation and promoted the apoptosis of ESCs. Additionally, the phosphorylation of AKT and expression of Cyclin D1, which were closely related with cellular growth, were distinctly lessened after treating with imatinib.
Conclusions
In summary, our study showed that GnRH-ant weakened the activization of c-kit receptor by decreasing its expression, causing the impaired growth ability of ESCs. Our findings provided a new insight into the effects of GnRH-ant on endometrium.
Residential environment in relation to self-report of respiratory and asthma symptoms among primary school children in a high-polluted urban area
Authors: Apichainan Nawarat , Norkaew Saowanee , Taneepanichskul Nutta
Published: September 2021

Respiratory disease and its complication are the cause of children deaths worldwide every year. Several epidemiological studies pointed out an association between quality of residential in inner city and risk of children health. Few studies had been focused on respiratory and asthma symptoms in high-polluted urban area in low to middle income countries. We conducted a cross-sectional study to investigate the association between residential environments and respiratory symptoms including asthma among 658 primary school children aged between 6 to 10 years who have been living in high-polluted urban area of Bangkok Thailand. The International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was modified and used for symptom self-report during the past 12 months. Binary logistic regression model was performed to find the associations. The results showed that living near garment and clothing shop is associated with shortness of breath (AOR = 1.846; 95%CI 1.034, 3.297). Vectors in home is related to dry cough at night (AOR = 1.505; 95%CI 1.052, 2.153) and phlegm (AOR = 1.414; 95%CI 1.014, 1.973). Wall dampness is increased odd of having wheezing or whistling (asthma) in the chest (AOR = 1.921; 95%CI 1.141, 3.235). Housing quality and living environments to reduce respiratory and asthma symptoms among urban children must be improved to address these risks.
Determination of Probability of Causative Pathogen in Infectious Keratitis Using Deep Learning Algorithm of Slit-Lamp Images
Authors: Koyama Ayumi , Miyazaki Dai , Nakagawa Yuji , Ayatsuka Yuji , Miyake Hitomi , Ehara Fumie , Sasaki Shin-ichi , Shimizu Yumiko , Inoue Yoshitsugu
Published: September 2021

Corneal opacities are an important cause of blindness, and its major etiology is infectious keratitis. Slit-lamp examinations are commonly used to determine the causative pathogen; however, their diagnostic accuracy is low even for experienced ophthalmologists. To characterize the “face” of an infected cornea, we have adapted a deep learning architecture used for facial recognition and applied it to determine a probability score for a specific pathogen causing keratitis. To record the diverse features and mitigate the uncertainty, batches of probability scores of 4 serial images taken from many angles or fluorescence staining were learned for score and decision level fusion using a gradient boosting decision tree. A total of 4306 slit-lamp images and 312 images obtained by internet publications on keratitis by bacteria, fungi, acanthamoeba, and herpes simplex virus (HSV) were studied. The created algorithm had a high overall accuracy of diagnosis, e.g., the accuracy/area under the curve (AUC) for acanthamoeba was 97.9%/0.995, bacteria was 90.7%/0.963, fungi was 95.0%/0.975, and HSV was 92.3%/0.946, by group K-fold validation, and it was robust to even the low resolution web images. We suggest that our hybrid deep learning-based algorithm be used as a simple and accurate method for computer-assisted diagnosis of infectious keratitis.
Factors Associated With Knowledge and Attitudes Towards Alcohol Consumption During Pregnancy Among Reproductive Women in West Gojjam Zone of Amhara Region: a Cross-sectional Study
Authors: Bayu Eyayu Kasseye , Demeke Getaneh Bizuayehu
Published: September 2021

Background: The aims of this study was to assess knowledge and attitudes of reproductive women (15-49) towards alcohol consumption during pregnancy in West Gojjam of Amhara region.Methods: Community based cross sectional study design was employed. The structured questionnaires were used to assess the knowledge and attitude of alcohol consumption among reproductive women during pregnancy. The sample size was calculated by using a single population proportion formula. Accordingly, the calculated sample size was 380 after adding 10% for non-response rate.Descriptive statistics, binary and multivariable logistic regressions was employed. Adjusted Odds Ratios together with corresponding 95% confidence intervals was used to interpret the findings.Results: The majority of women 308(82.4%) were know the problems of drinking alcohol during pregnancy from 374 total study participants. Knowledge of women with regard to problems of drinking alcohol during pregnancy were associated literate women (AOR=0.416; 95%CI=0.207-0.836) and risk of alcohol consumption during pregnancy low (AOR=9.468; 95% CI=3.466-25.868).Addationally,attitude of women for consumption of alcohol have significant effect on health associated with occupation status a housewife ((AOR=4.620; 95% CI= (1.255-17.012), had own business(AOR=17.344;95% CI=1.821165.148), alcohol consumption for 3-4 days a week(AOR=11.278;95%CI =1.231-103.287),relative encourage diriking alcohol (AOR=0.309;95%=0.110-0.868), Women who had previously health problems (AOR=0.330;95% CI=0.152-0.717), women who perceive the risk of alcohol consumption have beneficial effect on health is medium(AOR=7.112; 95% CI =3.108-16.270), attitudes of women towards alcohol consumption have beneficial effect on health is high (AOR= 4.902;95% CI =1.474-16.297),women who agree on the consumption of alcohol during pregnancy is valuable(AOR=0.082;95% CI =0.023-0.287).Conclusion: The study revealed that, the knowledge of women on the health effect of alcohol consumption during pregnancy high. Their attitude also towards alcohol consumption is low and medium. Interventions focused on creating awareness about the harmful effects of alcohol consumption on pregnancy should implemented.
Experimental Investigation on Granite Cutting by Means of Diamond Frame Saw
Authors: Wu Junjie , Zhang Jinsheng , Zhang Heng , Dong Peiyu , Ouyang Congsen , Wang Kaida
Published: September 2021

A great quantity of granite sawing experiments was carried out to explore the cutting performance offrame sawing machine with the horizontal reciprocating cutting mode.A model of average thickness of cutting chip was established, and characteristics of cutting forces were analyzed. The mechanism of wear was revealed by analyzing the width of the saw kerf and the wear morphology of the diamond segments. The results showed that the wear resistance and the cutting forces ncrease as the feed speed. The cutting forces change abruptly at the reversing point during granite cutting. At the same time, the proportion of macro-fractured and pulled-out particles and the mean wear rate of segments increase with the feed speed, and the mean protrusion height of the grits is less than 100 μm. The width of the saw kerf is gradually reduced as the sawing progresses, forming an inverted cone with a large upper side and a small lower side. Besides, the studies found that the wear of the segments remains consistent in two directions. The prominent phenomenon of the diamond particles on the side surface is more obvious as the feed speed increases.The research can provide certain data support for granite cutting, and lay the foundation for the subsequent optimization of the structure and equipment.
Autoregulation and Dual Stepping Mode of MYA2, an Arabidopsis Myosin XI Responsible for Cytoplasmic Streaming
Authors: Haraguchi Takashi , Ito Kohji , Morikawa Takamitsu , Shoji Nao , Iwaki Mitsuhiro , Tominaga Motoki
Published: September 2021

Arabidopsis thaliana has 13 genes belonging to the myosin XI family. Myosin XI-2 (MYA2) plays a major role in the generation of cytoplasmic streaming in cells. In this study, we investigated the molecular properties of MYA2 expressed by the baculovirus transfer system. Actin-activated ATPase activity and in vitro motility assays revealed that activity of MYA2 was regulated by the globular tail domain (GTD), When the GTD is not bound to the cargo, the GTD inhibits ADP dissociation from the motor domain. Optical nanometry of single MYA2 molecules, combining TIRF microscopy and the FIONA method, revealed that the MYA2 processively moved on actin with three different step sizes: −28 nm, 29 nm, and 60 nm, at low ATP concentrations. This result indicates that MYA2 uses two different stepping modes, hand-over-hand and inchworm-like. Force measurement using optical trapping showed the stall force of MYA2 was 0.85 pN, which was less than half that of myosin V (2 − 3 pN). These results indicated that MYA2 is more flexible than the myosin V responsible for vesicle transport in animal cells. Such flexibility may enable multiple myosin XIs to transport organelles quickly and smoothly, for the generation of cytoplasmic streaming in plant cells.
Data-Driven Analysis of Neutron Diffraction Line Profiles: Application to Plastically Deformed Ta
Authors: Tallman Aaron , Pokharel Reeju , Bamney Darshan , Spearot Douglas , Clausen Bjorn , Lebensohn Ricardo , Brown Donald , Capolungo Laurent
Published: September 2021

Non-destructive evaluation of plastically deformed metals, particularly diffraction line profile analysis (DLPA), is valuable both to estimate dislocation densities and arrangements and to validate microstructure-aware constitutive models. To date, the interpretation of whole line diffraction profiles relies on the use of semi-analytical models such as the extended convolutional multiple whole profile (eCMWP) method. This study introduces and validates two data-driven DLPA models to extract dislocation densities from experimentally gathered whole line diffraction profiles. Using two distinct virtual diffraction models accounting for both strain and instrument induced broadening, a database of virtual diffraction whole line profiles of Ta single crystals is generated using discrete dislocation dynamics. The databases are mined to create Gaussian process regression-based surrogate models, allowing dislocation densities to be extracted from experimental profiles. The method is validated against 11 experimentally gathered whole line diffraction profiles from plastically deformed Ta polycrystals. The newly proposed model predicts dislocation densities consistent with estimates from eCMWP. Advantageously, this data driven LPA model can distinguish broadening originating from the instrument and from the dislocation content even at low dislocation densities. Finally, the data-driven model is used to explore the effect of heterogeneous dislocation densities in microstructures containing grains, which may lead to more accurate data-driven predictions of dislocation density in plastically deformed polycrystals.
A Plan Robustness Qualification Method of Volumetric Arc Radiotherapy (VMAT) of Set Up Uncertainty in Nasopharyngeal Carcinoma (NPC) Radiotherapy
Authors: Ding Zhen , Xiang Xiaoyong , Zeng Qi , Ma Jun , Dai Zhitao , Kang Kailian , Bi Suyan
Published: September 2021

Purpose: To evaluate the set-up sensitivity of VMAT plans for Nasopharyngeal carcinoma (NPC) treatment by proposing a plan robustness evaluation method. Methods: 10 patients were selected for this study. A 2-arc volumetric-modulated arc therapy (VMAT) plan was generated for each patient using Varian Eclipse (13.6 Version) treatment planning system (TPS). 5 uncertainty plans (U-plans) were calculated based on the first 5 times set-up errors acquired from cone beam comuter tomography (CBCT). The dose differences and plan robustness of all the PTVs, CTVs, GTVs, and organs at risk (OARs) were analyzed. Tumor control probability (TCP) and normal tissues complication probability (NTCP) were calculated for biological evaluation. Results: The mean dose differences of D98 and D95 (△D98 and△D95) of PTVnx were respectively 3.30 Gy and 2.02 Gy. The △D98 and△D95 of CTVnx were 1.12 Gy and 0.58 Gy. The △D98 and△D95 of GTVnx were 0.56 Gy and 0.33 Gy. The dose coverage of GTVnx and CTVnx was guaranteed with minor dose variation. GTVnd exhibited strong robustness with little variation of D98 (0.5%) and D95 (0.9%). The △D98 and△D95 of CTVnd were 1.39 Gy and 1.03 Gy, distinctively lower than those in PTVnd (2.8 Gy and 2.0 Gy). No marked mean dose variations of Dmean were seen. The mean reduction of TCP (△TCP) in GTVnx and CTVnx were respectively 0.4% and 0.3%. The mean △TCP of GTVnd and CTVnd were 0.92 % and 1.3 % respectively. The CTV exhibited the largest △TCP (2.2 %). In OARs, the optical nerve chiasma was the one with the highest change, with a mean dose variation of 8.81 Gy. The Dmean of bilateral parotids varied in a large range. The mean reduction of NTCP (△NTCP) in the left parotid gland was 13.30%, which sharply increased the risk of parotid gland dysfunction. Conclusion: VMAT plans had a strong sensitivity to set-up uncertainty in NPC radiotherapy, due to the high degree of modulation. We proposed an effective method to evaluate the plan robustness of VMAT plans. Plan robustness and complexity should be taken into account in photon radiotherapy.
Return To Work After Cell Transplantation in Patients With Angiitis-Induced Critical Limb Ischemia and Factors Related
Authors: Liu Hao , Liu Yifan , Pan Tianyue , Fang Yuan , Fang Gang , Jiang Xiaolang , Chen Bin , Wei Zheng , Gu Shiyang , Liu Peng , Fu Weiguo , Dong Zhihui
Published: September 2021

Backgrounds:

Angiitis-induced critical limb ischemia (AICLI) patients, who are usually with young age and high amputation rate, always lose their labor force. Return to work (RTW), not only mean patients’ physical health for they could undertake the work but also demonstrate their psychological well-being. While cell transplantation showed satisfactory efficacy for AICLI patients, few studies in terms of AICLI patients’ returning to work after transplantation were reported.
Methods

From May 2009 to May 2021, AICLI patients who underwent cell transplantation and completed a no less than 12-month follow-up were retrospectively enrolled. Primary endpoint was RTW. Patients’ demographic characteristics, characteristics of ischemic limb, etc. were reviewed to analyze independent risk factors in terms of RTW.
Results

171 AICLI patients (170 males) were enrolled with a mean age of 41.9 ± 9.6 years (range, 20–57 years). The 12-month and 24-month RTW cumulative rates were 69.4% (95% confidence interval [CI] 61.6%-75.6%) and 70.1% (95% CI 62.3%-76.2%), respectively. Age < 40 years (OR 2.659, 95% CI 1.138–6.719), and preoperative job as mental workers (OR 8.930, 95% CI 2.665–42.847) were identified as independent protective factors for RTW, perioperative limb infection of patients with ulcer or gangrene (OR 0.250, 95% CI 0.075–0.779) was identified as independent risk factor.
Conclusion

AICLI patients who underwent cell transplantation were with a satisfactory mid-term RTW cumulative rate. AICLI patients < 40 years old with preoperative occupation as mental workers were more likely to return to work. Prevention of limb infection during the perioperative period is of great significance to RTW.
Quantifying the Spatial Distribution of Soil Nitrogen Under Long-Term Drip Fertigation
Authors: Bi Yaran , Wang Linlin , Wu Wenyong , Liao Renkuan , Bi xiangshuai , Hou Lizhu , Chen Yuehong
Published: September 2021

Quantifying the spatial distribution of nitrogen (N) in the soil under long-term drip fertigation events is essential for the optimal regulation of drip fertigation systems. In this study, a greenhouse soil that has been under drip irrigation for 20 years was selected as the research object, and soil samples were collected from 0-50 cm soil depth. The concentrations of N in soil samples were measured and their spatial distribution characteristics were quantified by classical statistical analysis and multifractal analysis. The results showed that long-term drip fertigation and the influence of natural factors resulted in the nitrate N mainly accumulating in the shallow layer of the soil and within a distance from the drip irrigation belt, and the spatial heterogeneity gradually decreased with increasing depth. The content of ammonium N was low and its distribution was observed in the whole section. Multifractal analysis indicated that the Δα value of nitrate N and inorganic N gradually increased with the increase of research scale, i.e., the spatial heterogeneity gradually increased, and it did not appreciably change for ammonium N. Meanwhile, the local high value region was the main factor leading to the spatial heterogeneity of N, and this dominant effect gradually increased with increasing depth. Multifractal analysis can effectively reflect the local information of N spatial distribution in the soil and provide a more detailed description of the spatial heterogeneity of soil properties.
Use of Candida auris Therapies based on Nanotechnology as Potential Novel Strategy against COVID-19 Infection
Authors: Nakazato Gerson , Favaro Wagner J , Castro Guillermo R , Duran Nelson
Published: August 2021

Candida auris, which is one of the causative agents of candidiasis, has been detected in several individuals with immune deficiency worldwide, mainly in different American countries, since 2012. C. auris infections are at risk of becoming epidemic because this species shows multi-drug resistance to several antifungal drugs available in the market; thus, since the current public health condition at global scale is threatened by the SARS-CoV-2 pandemic, C. auris infections could lead to high mortality rates. Different strategies, such as drug repurposing and the combination of antifungal drugs to other biocide molecules, were developed. However, they are time-limited strategies since drug resistance has increased due to C. auris pathologies. As an alternative, the recent development of nanotechnological devices has opened room for the efficient treatment of C. auris infections. Most specifically, the biocide effect of nanoparticles combined to/capped with antifungal drugs in different platforms seems to be an affordable technology to stop invasive C. auris infections.
THE EFFECT OF PARENTING STYLES ON PERSONALITY: A REVIEW OF LITERATURE
Authors:   Assistant Professor, Department of Psychology, School of Allied Healthcare and Sciences, Jain Deemed-to-be University, Bangalore, India., Roy Choudhury Nidhi , Roy Srimoyee ,   Msc Clinical Psychology, Department of Psychology, School of Allied Healthcare and Sciences, Jain Deemed-to-be University, Bangalore, India.
Published: September 2021

The influence of parents on childs development is extremely important. The impact a parent and family has on an individual is the foremost indicator of the holistic personality of that individual. Several researches are evident to the aspect that parental styles are very crucial factor that influences an adolescents behaviour, also the academic success besides other factors. Literature accords that based on Baumrinds model of Parenting Styles, authoritative parenting style is the most efficient in enhancing the academic achievement. Also that Permissive and neglectful parenting styles are the indicator styles for the abuse of alcohol among the adolescents and young adults. Thus the scope of this literature review is to filter out the significant factors influencing an individuals personality by assessing the aspects of academic achievement and alcohol use in accordance to parenting styles.
LYMPHANGIOME KYSTIQUE DU PANCREAS A PROPOS DUN CAS ET REVUE DE LA LITTERATURE
Authors:   Clinique chirurgicale C, Universite Mohamed V, Rabat, Maroc., Said Chairi Mohamed , Lemhouer Walid ,   Clinique chirurgicale C, Universite Mohamed V, Rabat, Maroc., Yassin Ilyasse ,   Clinique chirurgicale C, Universite Mohamed V, Rabat, Maroc., Bakali Youness ,   Clinique chirurgicale C, Universite Mohamed V, Rabat, Maroc., Samia Sassi ,   Departement de lanatomopathologie, Universite Mohamed V, Rabat, Maroc., Reguieg Naji ,   Departement de lanatomopathologie, Universite Mohamed V, Rabat, Maroc., Sabbah Farid ,   Clinique chirurgicale C, Universite Mohamed V, Rabat, Maroc., Mouna Alaoui ,   Clinique chirurgicale C, Universite Mohamed V, Rabat, Maroc., Znati Kawtar ,   Departement de lanatomopathologie, Universite Mohamed V, Rabat, Maroc., Mohamed Raiss ,   Clinique chirurgicale C, Universite Mohamed V, Rabat, Maroc., Hrora Abdelmalek ,   Clinique chirurgicale C, Universite Mohamed V, Rabat, Maroc.
Published: September 2021

Le lymphangiomekystique du pancreasestunetumeurbenigne, resultantdune obstruction de la circulation lymphatiquepancreatique. Son diagnostic estconfirme par letudehistologique de la lesion, lexerÃ¨sechirurgicaleest son traitement de choix. Une surveillance post-operatoireprolongeesimposeafin de detecter les recidiveslocoregionales.
TESTING THE EFFICACY OF VIRTUAL LABS IN INDIA FOR SIMULATION OF OPTICS EXPERIMENTS AT THE UNDERGRADUATE LEVEL
Authors:   Department of Physics, Maharaja Agrasen College, Vasundhara Enclave, Delhi University, Delhi., a Parthasarathi
Published: September 2021

Laboratory experimentation isan important ingredient of every undergraduate program in science education. The use of virtual and remote laboratories (VRLs) offers several benefits to students, teachers, and instructors. It can mitigate the high costs of procurement of apparatus in traditional labs and can support distance and blended learning. The recent outbreak of Covid-19 has resulted in isolating the students from labs which have made such online laboratories imperative even in the traditional offline education system. They offer a possible alternative to conventional hands-on labs. Such online mode imparts freedom to teachers as well as students to define their experimental goals and objectives. This paper tests the efficacy of the Virtual Labs platform for conducting simulated experiments onlinein the field of Optics. The learning outcome of the students who employ the same to simulate experiments online is analyzed. The main objective is to explore the limitations posed to the users of such an online lab platform in terms of designing the experimentsand visualization of the experiment results and offer suggestions to make such VRLs more efficacious, versatile, and user-friendly.
MOLECULAR BASED IDENTIFICATION OF BOLETUS EDULAIS FOUND IN JHARKHAND
Authors:   Research Scholar, PG Department of Botany, Ranchi University, Ranchi, Jharkhand., Rashmi Topno Kiroom , Kumar Srivastava Anjani ,   University Professor,PG Department of Botany, Ranchi, Jharkhand.
Published: September 2021

Food industry is dynamic and in search of innovation and nutrition content. Nutrition and food supplements demand can be fulfilled by mushroom.Agaricus(Button mushroom), Pleurotus (Oyster mushroom)and Volvariella(Paddy straw mushroom)are only popularly species cultivated and commercialized. There are many other wild mushrooms which can be commercialized with ethnomedicinal and rich nutrition content. In Jharkhand many wild mushroom species are found but they identified with many synonyms.(Srivastava and Soreng 2014) Identification is done on the basis of morphological structures and microscopic study of spores.(Pegler 1981, Wu2014) This study is to identify the wild mushroom locally called as Jamun khukhari through molecular characterization and report molecular data to NCBI GeneBank.
INNOCENCE AT THREAT: A STUDY OF CHILD LABOUR IN INDIA
Authors:   Assistant Professor in Political Science, Government College, Khandola, Goa, India., Bolivia Fernandes Priscilla
Published: September 2021

In this article I have found out that, how a child labour is the exclusionary form of social practice in our society, for which the child is too young to deal with such exploitation intelligently. I revealed how their innocence is in threat with the presence of various forms exploitation or human rights violation due to child labour.Besides this I also revealed about the presence of lack of awareness in the society about the child rights which allows them to employ the poor child as they find them as cheap labourand hence they can be paid half of what an adult worker would need to be paid.
LES TUMEURS INTRACANALAIRES PAPILLAIRES ET MUCINEUSES DU PANCREAS MULTIFOCALES : PRISE EN CHARGE ET ALTERNATIVES THERAPEUTIQUES POSSIBLES
Authors:   Clinique Chirurgicale C, Universite Mohamed V, Rabat, Maroc., Lemhouer Walid , Said Chairi Mohamed ,   Clinique Chirurgicale C, Universite Mohamed V, Rabat, Maroc., Yassin Ilyasse ,   Clinique Chirurgicale C, Universite Mohamed V, Rabat, Maroc., Bakali Youness ,   Clinique Chirurgicale C, Universite Mohamed V, Rabat, Maroc., Sabbah Farid ,   Clinique Chirurgicale C, Universite Mohamed V, Rabat, Maroc., Mohamed Raiss ,   Clinique Chirurgicale C, Universite Mohamed V, Rabat, Maroc., Hrora Abdelmalek ,   Clinique Chirurgicale C, Universite Mohamed V, Rabat, Maroc., Mouna EL Alaoui ,   Clinique Chirurgicale C, Universite Mohamed V, Rabat, Maroc.
Published: September 2021

La prise en charge des TIPMP ne fait pas encore consensus. Elle a largement evolue depuis les annees 1980. Initialement, toutes les TIPMP benignes ou malignes etaient resequees. Puis lanalyse histologique des pieces operatoires, la constatation que les lesions etaient souvent benignes et en dysplasie de bas grade, la morbi-mortalite non negligeable de la chirurgie pancreatique et des sequelles a long terme (insuffisance pancreatique endocrine notamment) ont fait reflechir. Lattitude est devenue plus attentiste, et lon differencie les lesions a risque de degenerescence, qui necessitent une resection prophylactique, des lesions a faible risque pouvant faire lobjet dune surveillance etroite. Ajoute a cela lemergence de nouvelles techniques dablation kystiques endoscopiques echo guidees le clinicien va faire face a un certain nombre de defis pour pouvoir decider de la meilleure prise en charge.
LA SPLENECTOMIE DANS LE TRAITEMENT DU SYNDROME DE BANTI : A PROPOS DUN CAS
Authors:   Clinique Chirurgicale C, Universite Mohamed V, Rabat, Maroc., Lemhouer Walid , El Gueddari Rania ,   Clinique Chirurgicale C, Universite Mohamed V, Rabat, Maroc., Yassin Ilyasse ,   Clinique Chirurgicale C, Universite Mohamed V, Rabat, Maroc., Said Chairi Mohamed ,   Clinique Chirurgicale C, Universite Mohamed V, Rabat, Maroc., Bakali Youness ,   Clinique Chirurgicale C, Universite Mohamed V, Rabat, Maroc., Mouna Alaoui ,   Clinique Chirurgicale C, Universite Mohamed V, Rabat, Maroc., Mohamed Raiss ,   Clinique Chirurgicale C, Universite Mohamed V, Rabat, Maroc., Hrora Abdelmalek ,   Clinique Chirurgicale C, Universite Mohamed V, Rabat, Maroc., Sabbah Farid ,   Clinique Chirurgicale C, Universite Mohamed V, Rabat, Maroc.
Published: September 2021

Le syndrome de BANTI est une affection connue mondialement, de pathogenie inconnue mais lorigine immunitaire est probable avec la rate au premier plan. Affection survenant avec predilection chez ladulte jeune aux alentours de la trentaine, avec predominance feminine. Dans notre etude une patiente de 36 ans ayant comme antecedents une notion de geophagie ÃƒÂ lenfance a ete admise pour un syndrome de Banti le diagnostic a ete etabli sur un faisceau darguments cliniques, biologiques, radiologiques et anatomopathologiques. La splenectomie associee ÃƒÂ la ligature des varices Ã…Â“sophagiennes pourraient ÃƒÂªtre suffisantes pour traiter ce syndrome et surtout ses consequences sans avoir recours ÃƒÂ une derivation spleno-renale.
ELDERLY DEPENDENCY IN INDIA: FINDINGS FROM CENSUS DATA
Authors:   MPhil Demography, Department of Demography, University of Kerala, Kariavattom-69558., J.A Geethu. , B. Nair Sajini ,   Social Scientist, Population Research Centre, Kerala, Ministry of Health and Family Welfare, Government of India, University of Kerala, Kariavattom-695581.
Published: September 2021

The changing demographic profile resulting in ageing of population has thrown many new challenges in the social, economic and political domains in India due to the huge number of aged population. The economic support to the older persons is very much dependent upon the earning ability of the adults. The study mainly focuses on the quantum of dependency burden and assesses the dependency burden in relation to the prevailing economic situation. The old age dependency ratio (OADR) in India estimated as ratio of population 60+ to that of 15-59 years is found to be 0.14 and the old age economic dependency ratio (OAEDR) is much higher at 0.23. Both OADR and OAEDR is highest in Kerala followed by Punjab and Haryana among the major states in India. Elderly dependency is high in most of the states and the economy is not prepared to bear the burden. The Economic Dependency ratio is almost three times the total dependency when we add the number of non workers 15-59 years in the dependent group and eliminate non workers 15-59 years from the economically active group in India. The unemployment rates are found to be quite high in states where the elderly dependency burden is higher. Increased longevity demands higher savings rates to cater to the needs of the old-old group. So the benefit of having a large working age population remains to be tapped through creating more employment opportunities.
SCHIZOPHRENIA AND EPILEPSY: WHAT LINKS BETWEEN? ARRAZI HOSPITAL EXPERIENCE ABOUT 56 CASES
Authors:   University Psychiatric Hospital Ar-Razi in Sale, Faculty of Medicine and Pharmacy, Mohammed V University of Rabat- Morocco., Benzahra S. , Karara A. ,   University Psychiatric Hospital Ar-Razi in Sale, Faculty of Medicine and Pharmacy, Mohammed V University of Rabat- Morocco., Nafiaa H. ,   University Psychiatric Hospital Ar-Razi in Sale, Faculty of Medicine and Pharmacy, Mohammed V University of Rabat- Morocco., Ouanass A. ,   University Psychiatric Hospital Ar-Razi in Sale, Faculty of Medicine and Pharmacy, Mohammed V University of Rabat- Morocco.
Published: September 2021

Background: Given the higher incidence of psychotic disorders in patients with epilepsy, several neurologists and psychiatrists have attempted to explain this controversial comorbidity. Thus, several hypotheses have been put forward but no link has been established with certainty until today. Objectives: The aim of our work is to draw up a socio-demographic and psychopathological profile of patients with schizophrenia-epilepsy comorbidity as well as to assess the risk of suicide, the management, the reasons for admission and the length of hospitalization. Methodology: we conducted a retrospective cross-sectional study on medical records of patients with schizophrenia and epilepsy who were hospitalized at the Ar-Razi University Psychiatric Hospital in SalÃ© between January 01, 2017 and March 31, 2021. Results: Our study included 56 patients. The average age was 33 + / - 9.83, 55% male. 50% of patients had attempted suicide in the past and 25% had a history of depressive episode, 41.1% had substance use disorder and 26.8% had a family history of psychosis. 85.7% of our patients developed schizophrenia from pre-existing epilepsy the time to onset of schizophrenia compared to epilepsy was 11.08 years +/- 7.71. The mean age of onset of schizophrenia is 23.3 years with a mean duration of progression of 9.18 years, 55.4% of patients were on monotherapy and 8.9% had resistant schizophrenia on clozapine. The average age of onset of epilepsy is 14.73 years, with generalized epilepsy in 84% of cases. The average length of stay is 42 days. The reasons for admission were as follows: hetero-aggression 78.6%, delusional verbalization 85.7% and suicide attempt 23.2%. The majority of our patients have been treated with atypical antipsychotics: Risperidone 30.4%, Amisulpride 21.4% and Aripiprazole 12.5%. Conclusion: The co-occurrence of schizophrenia epilepsy suggests the existence of possible common etiopathogenic factors. The management of this comorbidity requires a multidisciplinary collaboration between neurologist and psychiatrist, in order to confirm the diagnosis, establish a good therapeutic approach and propose a management algorithm taking into account the two pathologies.
DIVERSITY OFCHILD LABOUR AND ITS CAUSES IN DOWNTRODDEN FAMILIES IN DEVELOPING COUNTRIES - EVIDENCE FROM ODISHA, INDIA
Authors:   Research Scholar, Department of Anthropology, Sambalpur University, Odisha., Moharana Sanjukta
Published: September 2021

Child Labour, the global phenomenon is still existing in India due to lack of proper execution of programme and policies. Poverty, lack of parental guidance, lack of awareness about programs and influence of peer groups were the key countless reasons, which create a barrier to an individual as well as societal development. Global information shows that boys were more indulged in the labour market, however, trends have been changed now compared to earlier decades. Hence, the paper tried to comprehend the issue of child labour, its causes, reasons of drop out of school, and the effect of parents working status and familys condition on child labour. Primary cross-sectional research was conducted with an explorative research design, and information was sought from 300 samples randomly, across the Sambalpur district. The information was collected through a pre-tested and semi-structured questionnaire in the year 2019-20. Bivariate analysis was conducted in SPSS to understand the cause of child labour with different parameters and depict that parents economic and their working status do not influence much on the decision whether the child goes to the labour market or not. Besides, large family size and family type, majority parents incurred the income on alcohol consumption and maintenance of the family, which restrict them to think about their children education. The study recommends understanding the local need of the downtrodden family before executing the child labour policy as peer influence and self-interest to become child labour has been identified as a prime reason in the study.
The Predictive Value of the Pentraxin 3 Concentration in Cumulus Cell Culture Media for the Embryo Implantation
Authors: Irez Tulay , Sahin Yavuz , Malik Eduard , Guralp Onur
Published: September 2021

OBJECTIVE: Many studies on the interrelation of cumulus cells and oocytes, and research on cumulus protein factors continue. This study aims to investigate the relationship of Pentraxin 3 level with embryo implantation in the cumulus culture fluid.
STUDY DESIGN: A total of 31 women with idiopathic infertility who underwent intracytoplasmic sperm injection treatment were prospectively evaluated. Cell suspensions containing 5 million/mL cumulus cells were obtained post-hyase and incubated for 24 hours in a culture medium. A possible association between the culture media Pentraxin 3 concentrations and embryo implantation was analyzed.
RESULTS: The cumulus cell culture media Pentraxin 3 concentrations were significantly higher in the pregnant group compared to the non-pregnant group (98.9 ng/mL vs 53.2 ng/mL, respectively, p=0.005). There was a significant positive correlation between the culture media Pentraxin 3 concentrations and embryo implantation (r=0.500, p=0.005). The culture media Pentraxin 3 concentration was a significant predictor for successful embryo implantation (AUC=0.845, p=0.006). A cut-off value of 64.25 ng/mL had an 86% sensitivity and 80% specificity to predict embryo implantation. There was no pregnancy under the cut-off value of 60 ng/mL, whereby seven women had good quality grade 1 oocytes according to the traditional morphological criteria.
CONCLUSION: The cumulus cell culture medium Pentraxin 3 concentration was predictive for successful embryo implantation. Low Pentraxin 3 levels (<60 ng/mL were associated with failure of conception.
Garantías procesales en la aplicación de la inteligencia artificial y el Big Data en el estándar de la prueba penal
Authors: Pineda Jeison Estiven
Published: September 2021

El siguiente texto tiene como finalidad establecer cómo los avances científicos y tecnológicos que posee el fenómeno de la cuarta revolución industrial de pueden constituir mejoras en las garantías procesales penales dentro del estándar de más allá de toda duda razonable, a través de la inclusión de la Inteligencia Artificial y el Big Data en el marco del derecho probatorio en relación con elementos como: la prueba, la valorización de la prueba, la sana crítica y los medios probatorios.