bluuebunny/crossref_metadata_2025 huggingface dataset:
Фазы в октамере воды: молекулярный подход
Authors: Белега Е.Д. , Belega E.D.
Published: December 2017

Results of modeling of phases and phase transition in the water octamer with TIP4P interaction potential from molecular point of view are presented.
In the study the molecular dynamics method was applied. The advantage of using the dynamical characteristics of individual molecules in the cluster
is shown, particularly, the distribution of the potential energy, to identify the phase of the cluster. The criteria for solid like and liquid like
phases in the octamer are suggested and the connection isomer’s structures with dynamics are discussed. The role of different types of H-bonds
(DDA- and DAA-type) in dynamical characteristics of the cluster is clarified.
Filosofia e políticas editoriais da Revista Colombiana de Bioética
Authors: Escobar Triana Jaime
Published: December 2017

Filosofia e políticas editoriais da

Revista Colombiana de Bioética
Análisis Económico del Derecho penal y Derecho penal liberal: confluencias y bifurcaciones
Authors: Goldman Diego H.
Published: December 2017

No todo análisis económico lleva necesariamente a un Derecho penal maximalista que amenaza los derechos fundamentales de los individuos, sino que, por el contrario, es posible encontrar en la ciencia económica enfoques perfectamente compatibles con las corrientes más liberales del pensamiento penal. Este trabajo se propone hacer un estudio crítico de la teoría económica usualmente asociada al AED Penal, de sus implicancias prácticas y sus presupuestos teleológicos. La crítica partirá de una mirada abiertamente liberal, que defiende las ideas y valores que a lo largo de los siglos han expresado pensadores tan diversos como Adam Smith, Friedrich Von Hayek, Robert Nozick o Juan Bautista Alberdi.
De cultura a mercancía. la configuración de la propiedad intelectual en el marco de la Organización Mundial del Comercio
Authors: Ramos Toledano Joan
Published: December 2017

El presente trabajo trata de analizar las consecuencias de regular la propiedad intelectual en un marco pensado para el comercio, como la Organización Mundial del Comercio. La propiedad intelectual regula las expresiones artísticas, intelectuales o creativas –elementos fundamentales para el desarrollo de una sociedad–, y, sin embargo, su faceta de mercancía ha resultado decisiva a la hora de establecer la regulación internacional, basada en actitudes de imposición por parte de países poderosos frente a Estados menos desarrollados. En todo ese proceso, como se verá, la propia configuración de la OMC y sus dinámicas de funcionamiento han resultado fundamentales.
Eros e a Ciência da Informação
Authors: Mostafa Solange Puntel , Amorim Igor Soares , Sabbag Deise Maria Antonio
Published: December 2017

Experimentação sobre o deslizamento de planos entre filosofia, Ciência da Informação e Artes por meio da trilogia da incomunicabilidade formada pelos filmes dirigidos por Michelangelo Antonioni, com o objetivo de delinear e experimentar maneiras de indexar fora dos quadros do estruturalismo da Ciência da Informação. Faz-se uso do conceito filosófico de Linguagem Documentária Menor, ao apresentar novos termos para a indexação dos filmes mencionados, baseados na filosofia do cinema de Gilles Deleuze, especificando o estruturalismo da Ciência da Informação.
O vocabulário controlado do Governo Eletrônico: contribuições e limites na implementação da Lei de Acesso à Informação no Brasil
Authors: Gama Janyluce Rezende , Rodrigues Georgete Medleg
Published: December 2017

A Lei de Acesso à Informação, promulgada em 2011, introduziu um dispositivo permitindo que as solicitações de informação entrem por um único meio, independentemente do destinatário público. Esse sistema classifica os pedidos por meio de um vocabulário controlado que organiza e, teoricamente, facilitaria o processo para cidadãos e gestores públicos. Este artigo tem como objetivo verificar a contribuição e limites do vocabulário Controlado do Governo Eletrônico na implementação da Lei de Acesso à Informação no governo federal e é um recorte de uma pesquisa de doutorado em Ciência da Informação. Utilizou-se uma metodologia com abordagem qualitativa, que envolveu, na primeira etapa, uma pesquisa bibliográfica relacionada ao tema e o levantamento de informações sobre o vocabulário controlado do Governo Eletrônico, nas suas diversas versões, nos portais do governo federal, e, na segunda, uma consulta à Controladoria-Geral da União a respeito da estratégia de treinamento dos gestores públicos para o uso dessa ferramenta. Os resultados apontaram para um esforço por parte do governo federal em avançar na melhoria da classificação das funções de governo para classificar as demandas decorrentes da Lei de Acesso à Informação. Porém, consulta à Controladoria-Geral da União, além de informações obtidas com alguns gestores e outros dados empíricos da pesquisa de doutorado, mostrou os limites desses esforços quanto ao treinamento dos gestores públicos no uso dessa ferramenta de gestão.
A altmetria na prática e o papel dos bibliotecários no seu uso e aplicação
Authors: Araujo Ronaldo Ferreira
Published: December 2017

Resenha do livro Altmetria para bibliotecários: guia prático de métricas alternativas para avaliação da produção científica de Andrea Gonçalves do Nascimento. A obra apresenta os conceitos básicos e principais aplicações das métricas alternativas, elucidando questões gerais e específicas a sua compreensão tendo como foco principal seu uso prático pelos profissionais bibliotecários.
A Distally Based Sartorius Muscle Flap for a Gustilo Grade-III Open Fracture of the Lateral Femoral Condyle and the Head of the Fibula with a Complex Soft-Tissue Defect
Authors: Bouveau Victoire , Potage Damien , Dubory Arnaud , Chevallier Romain , Meningaud Jean-Paul , Niddam Jérémy , Flouzat-Lachaniette Charles-Henri
Published: December 2017

Case:

We present a case of lower-limb trauma associated with an extensive soft-tissue defect around the knee joint, which led to the exposure of bone and the metalwork that was used for the management of the associated fractures. Coverage was performed with a distally based sartorius muscle flap in a single-stage procedure, allowing good recovery with a nice aesthetic and functional outcome at the 1-year follow-up. Additionally, we discuss alternative options for the coverage of severe soft-tissue defects based on the clinical context.

Conclusion:

A distally based sartorius muscle flap may be a suitable alternative for coverage of complex soft-tissue defects around the knee joint.
Microemulsion Phase-Behavior Equation-of-State Model Using Empirical Trends in Chemical Potentials
Authors: Torrealba V. A. , Johns R. T.
Published: December 2017

Surfactant-based enhanced oil recovery (EOR) is a promising technique because of surfactant's ability to mobilize previously trapped oil by significantly reducing capillary forces at the pore scale. However, the field-implementation of these techniques is challenged by the high cost of chemicals, which makes the margin of error for the deployment of such methods increasingly narrow. Some commonly recognized issues are surfactant adsorption, surfactant partitioning to the excess phases, thermal and physical degradation, and scale-representative phase behavior.

Recent contributions to the petroleum-engineering literature have used the hydrophilic/lipophilic-difference net-average-curvature (HLD-NAC) model to develop a phase-behavior equation of state (EoS) to fit experimental data and predict phase behavior away from tuned data. The model currently assumes spherical micelles and constant three-phase correlation length, which may yield errors in the bicontinuous region where micelles transition into cylindrical and planar shapes.

In this paper, we introduce a new empirical phase-behavior model that is based on chemical-potential (CP) trends and HLD that eliminates NAC so that spherical micelles and the constant three-phase correlation length are no longer assumed. The model is able to describe all two-phase regions, and is shown to represent accurately experimental data at fixed composition and changing HLD (e.g., a salinity scan) as well as variable-composition data at fixed HLD. Further, the model is extended to account for surfactant partitioning into the excess phases. The model is benchmarked against experimental data (considering both pure-alkane and crude-oil cases), showing excellent fits and predictions for a wide variety of experiments, and is compared to the recently developed HLD-NAC EoS model for reference.
Identification and Expression Analysis of Multiple Ferric Chelate Reductases in Citrus junos
Authors: Yao Li-Xiao , He Yong-Rui , Fan Hai-Fang , Xu Lan-Zhen , Lei Tian-Gang , Zou Xiu-Ping , Peng Ai-Hong , Li Qiang , Chen Shan-Chun
Published: December 2017

Ferric chelate reductase (FRO) is a critical enzyme for iron absorption in strategy I plants, reducing Fe3+ to Fe2+. To identify FRO family genes in the local Citrus junos cultivar Ziyang Xiangcheng and to reveal their expression model, the citrus (Citrus sp.) genome was searched for homologies of the published sequence CjFRO1. Five FROs were found, including CjFRO1; these were named CjFRO2, CjFRO3, CjFRO4, and CjFRO5, respectively, and cloned via reverse transcription polymerase chain reaction (RT-PCR) and rapid amplification of cDNA ends (RACE) PCR. The deduced amino acid sequences of five CjFROs contained flavin adenine dinucleotide (FAD)-binding motifs, nicotinamide adenine dinucleotide (NAD)-binding motifs, and 6–10 transmembrane domains, with isoelectric points between 6.73 and 9.46, and molecular weights between 67.2 and 79.9 kD. CjFRO1 and CjFRO2 were predominantly found in the aboveground parts of C. junos, with CjFRO1 highly expressed in leaves, and CjFRO2 largely expressed in stems and leaves. CjFRO3 was less expressed in roots, stems, and leaves. CjFRO4 and CjFRO5 were predominately found in roots. Under iron-deficient conditions, CjFRO4 was significantly and specifically increased in the roots of C. junos, whereas CjFRO1 was upregulated in the roots and leaves.
Long-run analysis of Environmental Kuznets Curve in the Middle East and North Africa
Authors: Ben Zaied Younes , Ben Cheikh Nidhaleddine , Nguyen Pascal
Published: December 2017

The main originality of this paper is to empirically investigate the long-run relationship between carbone dioxide (CO2) emissions, energy use and real GDP per capita in the Middle East and North Africa (MENA) during the last three decades. Using panel cointegration tests (Westerlund, (2007) and DOLS estimation method, we validate the Environmental Kuznets Curve (EKC) hypothesis in the long run for the MENA region countries. Therefore, we conclude that oil producer countries have adopted several policy decisions in favor of CO2 emissions reduction. The estimated turning point of the EKC confirms our intuitions that only oil producer countries achieve CO2 emissions reduction goal.
Students’ Needs to Develop English Writing Materials
Authors: Sumarsono Dedi , Bagis Abdul Kadir , Arrafii Moh. Arsyad
Published: December 2017

This research explored sophomore students’ needs in learning English writing at the Faculty of Education for Language and Arts, IKIP Mataram. To achieve this purpose, classroom observation, questionnaire, and documentation were conducted to collect data. Data were then analyzed descriptively, and triangulation of data analysis was also carried out. Based on the result of the questionnaire survey, the findings show that the students’ proficiency level is at the elementary level. Moreover, the students’ needs in learning writing include picture-enriched materials, academic writing, tourism-related topics, cooperative learning in use, and theories-driven writing materials. The findings are used as foundation knowledge to develop writing materials for students.
A Semiotic Study of One Ready-To-Drink Tea Billboard Advertisement in Jakarta
Authors: Da Silva Anna Marietta
Published: December 2017

The purpose of this research was to delve into the linguistic and non-linguistic aspects of a pioneer brand of bottled green tea in the Indonesian market. Four main aspects of the Semiotics study, namely the represented participants, modality, composition, and interactive participants were used to analyze the advertisement. The data for this research was a billboard of Nü Green Tea that was placed in Jl. Kasablanka Raya in South Jakarta. The findings show that the interplay between the non-human object, play of colors, composition, and language choice has been designed carefully in order to boost the targeted audience’s attention to the product.
Dampak Drama, Anime, dan Musik Jepang terhadap Minat Belajar Bahasa Jepang
Authors: Novianti Nalti
Published: December 2017

As a fast growing country in Asia, Japan is placed on higher country, neither in government rule connected with social community or in the economy system. The growth of the country has attracted public attention that makes people want to learn the Japanese language. Many high quality of Japan products are enjoyed by the Indonesian people, especially the ones that connected with media, such as comic books, anime, and play. The problem is whether the students of Japanese language that learning the Japanese language in the university are interested in studying it because of the influence of the products. After doing field research on four different universities that having Japanese Departments, it can be concluded that the influence does not exist. The students choose Japanese Literature because they like Japan and want to learn the language.
NARRATIVE DISCOURSE ANALYSIS OF A FOREIGNER’S STORY DURING HIS WORK IN INDONESIA
Authors: Wiannastiti Melania
Published: December 2017

This article is concerned with the study of appraisal of a foreigner who worked in Indonesia.The aim is to find out some personal feeling of working in Indonesia. An Australian who worked inIndonesia during some period of time was the main respondent. There are three episodes ofconversation through the internet chat, namely Yahoo Messenger between the writer and therespondent. The conversation transcript was used as the data. Narrative story and discourse analysiswere used as a perspective approach to analyze the story. The important themes discussed in the studyare affect, appreciation, personal and moral judgment, and social judgment.
Characters that Suffered Due to Shortage in the Characters
Authors: Feng Ma
Published: December 2017

In this article, the theories about motif and type will be used for analyzing the very types of characters that suffered because of the shortages. To begin with, the analyzing of the differences and similarities of the shortages of each character will be counted on the inside and outside parts of their sufferings. Then the theories of Nietzsche’s and of some myths will be used for analyzing the further reason of the sufferings. At last, investigating the special value those sufferings have brought for literatures and for TV series. Multi-angle perspective is useful for investigating the unique charms of the shortages of characters as well as for finding out new understandings for the types of sufferings.
Hydrochemistry and water quality assessment of the Maroon River in Behbahan area, SW Iran
Authors: Ehya Farhad , Moghadam Zeynab Firouzeh
Published: December 2017

Assessing water quality is important in optimizing water usage. In this study, six water samples were taken from points along the Maroon River in order to evaluate its quality. The concentrations of Cl−, SO42−, HCO3−, CO32−, NO3−, K+, Mg2+, Na+, and Ca2+, as well as pH, electrical conductivity (EC) and total dissolved solids (TDS) were measured. The results were compared with the WHO (World Health Organization) drinking water guidelines and the FAO (Food and Agricultural Organization of United Nations) standard for irrigation water. The values of EC, TDS, Ca2+, Cl− and SO42− in two samples, and that of Mg2+ in one sample from downstream exceed WHO recommended limits. The K+, Na+ and NO3− concentrations are below the WHO limits. The dominant water facies is bicarbonate-calcium (HCO3-Ca). A Schoeller diagram shows that the water samples are of ‘Good’ and ‘Intermediate’ classes, while a Wilcox diagram reveals that the water is in classes C2S1, C3S3 and C3S2 – i.e., ‘Good’ or ‘Intermediate’ – for agricultural purposes. The water quality indices %Na, sodium adsorption ratio (SAR), residual sodium carbonate (RSC), permeability index (PI), magnesium adsorption ratio (MAR) and Kelly's ratio (KR), also indicate that the water is suitable for irrigation. In terms of EC, the water samples are of ‘Good’ and ‘Permissible’ quality. Geochemical investigations show that the water chemistry is influenced by evaporation, dissolution of evaporitic minerals, ion exchange and human activities.
Development of a tool for improving the management of gaseous emissions in UASB-based sewage treatment plants
Authors: Chernicharo C. A. L. , Brandt E. M. F , Bressani-Ribeiro T. , Melo V. R. , Bianchetti F. J. , MotaFilho C. R. , McAdam E.
Published: December 2017

This study aimed at developing a simple tool for improving the management of gaseous emissions in UASB-based sewage treatment plants (STPs), considering different scenarios for the management of sludge, biogas and gaseous emissions (especially sulfide and methane). For small STPs (<10,000 inhab.), simple alternatives for the use of biogas were considered (e.g. for excess sludge hygienization and household usages). For medium- (>10,000; <100,000) and large-scale (>100,000 inhab.) STPs, other biogas uses were considered, such as in sludge dryers, boilers or combined heat and power engines for electricity generation and heat recovery. All these possibilities were grouped in an interactive spreadsheet containing an extensive database of factors that affect gaseous emissions and energy balance in STPs. The tool can be important for decision makers choosing the best gaseous emissions management practices in UASB-based STPs. Carbon footprint should be the main decision factor when evaluating alternatives for the management of gaseous emissions.
Customer satisfaction survey: the case of urban water supply services in Southern Ethiopia
Authors: Kassa Kinfe , Chernet Melkie , Kelemework Getahun , Zewde Binyam , Woldemedhin Adane
Published: December 2017

Service quality and customer satisfaction are very important concepts that water enterprises must understand and measure from the customers' perspective to satisfy their needs. The main objectives of this research were to assess the level of customer satisfaction on urban water supply services of Southern Region, Ethiopia, and identify major determinants. Quantitative data were collected from 8,413 customers in seventeen towns, using a questionnaire based on the SERVQUAL model. Qualitative data were collected from customers via focus group discussion, and interviews were used with utility employees and officials. The results showed 47% of customers were satisfied with the water supply enterprise services, while 43% were dissatisfied for various reasons. The customer satisfaction score was below the acceptable level for all service quality dimensions, and understanding of customers, communication, and responsiveness were far below the benchmark. The correlation analysis revealed the existence of a monotonic, positive relationship between customers' total satisfaction and service quality dimensions. The proportional odds model indicated that total customer satisfaction was highly dependent on the nine service quality dimensions used in this research.
Removal of phosphate from aqueous solution by sewage sludge-based activated carbon loaded with pyrolusite
Authors: Yao Sicong , Wang Meicheng , Liu Jilong , Tang Shuxiong , Chen Hengli , Guo Tiecheng , Yang Ge , Chen Yao
Published: December 2017

Activated carbons were prepared from sewage sludge by chemical activation with pyrolusite (PAC) to develop an efficient adsorbent for phosphate removal from aqueous solution. One percent (wt.) pyrolusite addition was proved to have an important effect on pore formation of the produced carbon. PAC showed 17.06% larger Brunauer–Emmett–Teller (BET) surface area than the sewage sludge-based activated carbon without modification (SAC). The adsorption results showed that the phosphate removal by PAC was 13% higher than SAC's. The adsorption experiments also showed that PAC had very good performance with high phosphate removal rate (ca. 90%) in a wide pH range (pH = 4–8), and could be stable after 30 min reaction. Adsorption isotherm and kinetics studies demonstrated that phosphate adsorption onto the modified adsorbent was well fitted by the Langmuir isotherm and could be described by the pseudo-second-order kinetic model. The modified sewage sludge-based activated carbons were effective and alternative adsorbents for the removal of phosphorus from aqueous solution due to their considerable adsorptive capacities and the low-cost renewable sources.
Plant-Made Antibodies: Properties and Therapeutic Applications
Authors: Komarova Tatiana V. , Sheshukova Ekaterina V. , Dorokhov Yuri L.
Published: December 2017

Background:

A cost-effective plant platform for therapeutic monoclonal antibody production is both flexible and scalable. Plant cells have mechanisms for protein synthesis and posttranslational modification, including glycosylation, similar to those in animal cells. However, plants produce less complex and diverse Asn-attached glycans compared to animal cells and contain plant-specific residues. Nevertheless, plant-made antibodies (PMAbs) could be advantageous compared to those produced in animal cells due to the absence of a risk of contamination from nucleic acids or proteins of animal origin.

Objective:

In this review, the various platforms of PMAbs production are described, and the widely used transient expression system based on Agrobacterium-mediated delivery of genetic material into plant cells is discussed in detail.

Results:

We examined the features of and approaches to humanizing the Asn-linked glycan of PMAbs. The prospects for PMAbs in the prevention and treatment of human infectious diseases have been illustrated by promising results with PMAbs against human immunodeficiency virus, rotavirus infection, human respiratory syncytial virus, rabies, anthrax and Ebola virus. The pre-clinical and clinical trials of PMAbs against different types of cancer, including lymphoma and breast cancer, are addressed.

Conclusion:

PMAb biosafety assessments in patients suggest that it has no side effects, although this does not completely remove concerns about the potential immunogenicity of some plant glycans in humans. Several PMAbs at various developmental stages have been proposed. Promise for the clinical use of PMAbs is aimed at the treatment of viral and bacterial infections as well as in anti-cancer treatment.
Extrahepatic Autoimmune Diseases are Prevalent in Autoimmune Hepatitis Patients and Their First-Degree Relatives: Survey Study (Preprint)
Authors: Fogel Rachel , Comerford Megan , Chilukuri Prianka , Orman Eric , Chalasani Naga , Lammert Craig
Published: December 2017

BACKGROUND

Concurrent autoimmune illnesses contribute to increased medical burden and reduced quality of life in patients with autoimmune hepatitis (AIH). The frequency of coexisting autoimmune conditions among North American patients with AIH and their families remains incomplete. Challenges associated with disease capture in the electronic medical record, high study costs, and geographic spread of patients are formidable barriers to understanding the extent of concurrent autoimmune conditions in these groups.

OBJECTIVE

This objective of this study was to examine the frequency of extrahepatic autoimmune diseases (EHAD) among AIH cases and healthy controls as well as their first-degree relatives using social networking sites (SNS).

METHODS

We developed a 53-question survey detailing the history of autoimmune diseases. A survey link was posted at routine intervals within specific Web-based cohorts on SNS. Healthy controls, without self-reported autoimmune liver disease, were recruited from Amazon’s Mechanical Turk. Continuous variables were summarized using medians and P values obtained with the Wilcoxon rank-sum test. Categorical variables were compared using the chi-square test.

RESULTS

Compared with controls (n=1162), cases (n=306) were more likely to be older (median age: 49 vs 33 years), female (284/306, 92.81% vs 955/1162, 82.18%), and have an EHAD (128/306, 41.83% vs 218/1162, 18.76%; P=.001). The most frequent EHADs among cases were thyroid disease (49/306, 16.01% ), Sjögren syndrome (27/306, 8.82%), Raynaud phenomenon (23/306, 7.52%), and psoriasis (22/306, 7.19%). Overall, 55.88% (171/306) of cases and 35.71% (1601/4484) of controls reported at least 1 first-degree relative (FDR) with a history of EHAD (P=.001). Cases had a significantly higher risk of EHAD than controls after the adjustment for age, sex, race, and body mass index: odds ratio 2.46 (95% CI 1.8-3.3); P=.001.

CONCLUSIONS

Patients with AIH report higher prevalence of coexistent EHAD than healthy controls, and their FDRs are also more likely to have autoimmune disorders.
The Burden of a Remote Trial in a Nursing Home Setting: Qualitative Study (Preprint)
Authors: Donnelly Susie , Reginatto Brenda , Kearns Oisin , Mc Carthy Marie , Byrom Bill , Muehlhausen Willie , Caulfield Brian
Published: December 2017

BACKGROUND

Despite an aging population, older adults are typically underrecruited in clinical trials, often because of the perceived burden associated with participation, particularly travel associated with clinic visits. Conducting a clinical trial remotely presents an opportunity to leverage mobile and wearable technologies to bring the research to the patient. However, the burden associated with shifting clinical research to a remote site requires exploration. While a remote trial may reduce patient burden, the extent to which this shifts burden on the other stakeholders needs to be investigated.

OBJECTIVE

The aim of this study was to explore the burden associated with a remote trial in a nursing home setting on both staff and residents.

METHODS

Using results from a grounded analysis of qualitative data, this study explored and characterized the burden associated with a remote trial conducted in a nursing home in Dublin, Ireland. A total of 11 residents were recruited to participate in this trial (mean age: 80 years; age range: 67-93 years). To support research activities, we also recruited 10 nursing home staff members, including health care assistants, an activities co-ordinator, and senior nurses. This study captured the lived experience of this remote trial among staff and residents and explored the burden associated with participation. At the end of the trial, a total of 6 residents and 8 members of staff participated in semistructured interviews (n=14). They reviewed clinical data generated by mobile and wearable devices and reflected upon their trial-related experiences.

RESULTS

Staff reported extensive burden in fulfilling their roles and responsibilities to support activities of the trial. Among staff, we found eight key characteristics of burden: (1) comprehension, (2) time, (3) communication, (4) emotional load, (5) cognitive load, (6) research engagement, (7) logistical burden, and (8) product accountability. Residents reported comparatively less burden. Among residents, we found only four key characteristics of burden: (1) comprehension, (2) adherence, (3) emotional load, and (4) personal space.

CONCLUSIONS

A remote trial in a nursing home setting can minimize the burden on residents and enable inclusive participation. However, it arguably creates additional burden on staff, particularly where they have a role to play in locally supporting and maintaining technology as part of data collection. Future research should examine how to measure and minimize the burden associated with data collection in remote trials.
Mozart KV 448 Menurunkan Densitas dan Aktivitas Neuroglia Hipokampus Mencit (Mus musculus) Selama Stres Prenatal No. 416-KE
Authors: Kusumarini Shelly , Yustinasari Lita Rakhma , Hestianah Eka Pramystha , Kuncorojati Suryo , Juniastuti Tutik
Published: December 2017

The aim of this research was to explore the influence of Mozart KV 448 classical music therapy to the neuroglia cells of mice’s hippocampus that were exposed to stress during prenatal. This research were employing twenty female mices and twenty male mices. Female mices were estrus synchronized with PMSG and hCG then monomating to the males. Pregnant females were then divided into four groups (P0, P1, P2, P3). P0 was as control, P1 was treated by one minute forced swim test, P2 was treated by one minute forced swim test followed by thirtyminutes classical music Mozart KV 448 and P3 was treated by one minute forced swim test followed by sixty minutes classical music Mozart KV 448. This research was carried out for twenty-one days during gestation period. The neuroglia density result was analyzed using ANOVA and Duncan test. The neuroglia activity result wasanalyzed using Kruskal wallis test and Z test. The histology reading showed degradation of density and activity of hippocampus neuroglia.
Perlakuan Celup Puting setelah Pemerahan terhadap Keberadaan Bakteri Patogen, Staphylococcus aureus, Streptococcus agalactiae, dan E. coli pada Sapi Perah Penderita Mastitis Subklinis di Peternakan KUNAK Bogor
Authors: Pisestyani Herwin , Sudarnika Etih , Ramadhanita Rachmi , Ilyas Abdul Zahid , Basri Chaerul , Wicaksono Ardilasunu , Nugraha Arifin Budiman , Sudarwanto1 Mirnawati B
Published: December 2017

Mastitis is udder inflammation that can be caused by the entry of pathogenic bacteria through the teat. One of the treatments that can prevent bacteria infection is teat dipping. This research was aimed to identify the effectof teat dipping after milking to the presence of pathogenic bacteria that cause subclinical mastitis (Staphylococcus aureus, Streptococcus agalactiae, and Escherichia coli) and the presence of pathogenic bacteria that cause subclinicalmastitis by quarter of udder. Milk samples were taken from normal lactation period of dairy cows, clinically healthy, and positive subclinical mastitis status when the intervention was applied. Sixty seven samples of quarters from 18dairy cows were identified to the presence of pathogenic bacteria that cause subclinical mastitis before teat dipping and at 1st, 2nd, and 3rd months after teat dipping. Identification of the presence of pathogenic bacteria was done byculturing samples on selective agar media. The presence of common pathogenic bacteria, Staphylococcus aureus, and Escherichia coli decreased significantly after teat dipping, while Streptococcus agalactiae and other pathogenicbacteria did not decrease significantly. The presence of pathogenic bacteria based on the quarter of udder did not show the significance difference. Application of teat dipping after milking was able to decrease the presence ofpathogenic bacteria that cause subclinical mastitis.
Cost–effectiveness analysis of treatments involving radioembolization in intermediate-stage hepatocellular carcinoma
Authors: Rognoni Carla , Ciani Oriana , Sommariva Silvia , Tarricone Rosanna
Published: December 2017

Aim:
We evaluated two treatment sequences, transarterial radioembolization followed by transarterial chemoembolization and possibly sorafenib (=TTS) versus transarterial radioembolization followed by sorafenib alone (=TS), to identify the most cost-effective pathway to treat intermediate-stage hepatocellular carcinoma from the Italian healthcare system perspective.
Materials & methods:
A Markov model was developed to project costs and health outcomes for TTS and TS over a lifetime horizon. Data available at three hospitals in Italy were collected. Healthcare resource utilization was derived from standard clinical protocols. Costs were obtained from official regional tariffs.
Results & Conclusion:
Taking into consideration 16 patients for TTS and 22 patients for TS pathways, the TTS sequence provided a dominant strategy in comparison to TS. Further evidence is desirable to confirm these results.
Personalizing Type 2 Diabetes Management: Use of a Patient-Centered Approach to Individualizing A1C Goals and Pharmacological Regimens
Authors: Lahiri Sharon W.
Published: December 2017

IN BRIEF Caring for people with type 2 diabetes requires a patient-centered approach to treatment targets and medication regimens. Focusing on patients’ individual characteristics, needs, and treatment responses can improve compliance and clinical outcomes. Medication selection can be guided by the mechanisms of action, advantages, disadvantages, and costs of available options; patients’ behavioral and psychological variables, personal preferences, and socioeconomic status also should be taken into account. This article provides an overview of patient-centered and individualized diabetes management, offers pharmacological recommendations for specific clinical scenarios, and describes a complicated case illustrating the patient-centered approach in clinical practice.
Urinary bisphenol A and obesity in adults: results from the Canadian Health Measures Survey
Authors: Do Minh T. , Chang Vicky C. , Mendez Michelle A. , de Groh Margaret
Published: December 2017

Introduction

Exposure to bisphenol A (BPA) has been shown to affect lipid metabolism
and promote weight gain in animal studies. Recent epidemiological studies also
support a link between BPA and obesity in human populations, although many were
limited to a single adiposity measure or have not considered potential confounding by
dietary factors. The purpose of this study is to examine associations between urinary
BPA and adiposity measures in a nationally representative sample of Canadian adults.

Methods

We performed analyses using biomonitoring and directly measured anthropometric
data from 4733 adults aged 18 to 79 years in the Canadian Health Measures
Survey (2007–2011). We used multinomial and binary logistic regression models to estimate
associations of urinary BPA with body mass index (BMI) categories (overweight
vs. under/normal weight; obesity vs. under/normal weight) and elevated waist circumference
(males: ≥ 102 cm; females: ≥ 88 cm), respectively, while controlling for potential
confounders. Linear regression analyses were also performed to assess associations
between urinary BPA and continuous BMI and waist circumference measures.

Results

Urinary BPA was positively associated with BMI-defined obesity, with an odds
ratio of 1.54 (95% confidence interval [CI]: 1.002–2.37) in the highest (vs. lowest) BPA
quartile (test for trend, p = .041). Urinary BPA was not associated with elevated waist
circumference defined using standard cut-offs. Additionally, each natural-log unit
increase in urinary BPA concentration was associated with a 0.33 kg/m2 (95% CI: 0.10–
0.57) increase in BMI and a 1.00 cm (95% CI: 0.34–1.65) increase in waist
circumference.

Conclusion

Our study contributes to the growing body of evidence that BPA is positively
associated with obesity. Prospective studies with repeated measures are needed
to address temporality and improve exposure classification.
Consommation d’alcool et lignes directrices pour la consommation d’alcool à faible risque chez les adultes : une analyse transversale de l’Alberta’s Tomorrow Project
Authors: Brenner Darren R. , Haig Tiffany R. , Poirier Abbey E. , Akawung Alianu , Friedenreich Christine M. , Robson Paula J.
Published: December 2017

Introduction

La consommation modérée ou élevée d’alcool constitue un facteur de risque
de mortalité toutes causes confondues et de cancer. Nous disposons de données
transversales grâce aux enquêtes nationales, mais jusqu'à présent aucunes données sur la
consommation d’alcool en Alberta n'étaient disponibles pour une grande cohorte prospective.
Notre objectif est de définir, à la lumière des lignes directrices de prévention du
cancer, les niveaux de consommation d’alcool des adultes ayant pris part à l’Alberta’s
Tomorrow Project. Nous avons également analysé les liens entre la consommation
d’alcool et certains autres comportements à risque, en particulier à risque élevé.

Méthodologie

Entre 2001 et 2009, 31 072 hommes et femmes de 35 à 69 ans ont participé
à l’Alberta’s Tomorrow Project, une grande étude de cohorte provinciale. Des données
concernant la consommation d’alcool dans les 12 derniers mois ont été obtenues
pour 26 842 participants ayant répondu à des questionnaires autoadministrés sur la santé
et sur le mode de vie. Nous avons effectué des analyses transversales sur la consommation
d’alcool quotidienne et les lignes directrices de prévention du cancer en matière de
consommation d’alcool en lien avec des facteurs sociodémographiques. Nous avons aussi
examiné la prévalence combinée de la consommation d’alcool, du tabagisme, de l’obésité
et de diverses comorbidités.

Résultats

Environ 14 % des hommes et 12 % des femmes ont déclaré consommer
davantage d’alcool que ce que préconisent les recommandations en matière de prévention
du cancer. Une consommation plus importante d’alcool a été rapportée chez les plus
jeunes, les citadins, les personnes à revenu plus élevé et celles consommant davantage de
viande rouge. En outre, le volume de consommation quotidienne d’alcool était positivement
associé au tabagisme, tant chez les hommes que chez les femmes. De manière
générale, les hommes étaient plus susceptibles que les femmes de correspondre aux profils
comportementaux à risque modéré et élevé ainsi que de consommer quotidiennement
de l'alcool.

Conclusion

Malgré les messages de santé publique à propos de l’impact négatif de la
consommation d’alcool, une proportion considérable de participants de l’Alberta’s
Tomorrow Project consommait davantage d’alcool que ce que préconisent les recommandations
en matière de prévention du cancer. Des stratégies durables en faveur d'une consommation
d’alcool à faible risque auprès de ceux qui choisissent de boire pourraient
avoir une influence sur le risque de maladie chronique au sein de cette population.
Pacific journalism education and training - the new advocacy era
Authors: Smith Mackenzie
Published: December 2017

For years, journalism education training in the Pacific has relied on donor funded short courses and expatriate media educators but in recent times this has been changing with the growth of more journalism schools at both universities and technical institutes and a more home grown actively qualified staff and proliferating research programmes. These changes can be reflected with the establishment of the new advocacy group, Media Educators Pacific (MEP). This is chaired by Misa Vicky Lepou, the president and she is also the head of journalism at the National University of Samoa. This body has a mission to promote and deliver the highest professional standards of training, education and research in media and journalism education relevant to the Pacific and beyond. In a region where the news media and journalism education have been forced to confront major hurdles such as military coups, as in Fiji; ethnic conflict, as in the Solomon Islands; and two rival governments and the ruthless crushing of student protests in Papua New Guinea in June 2016, major questions are faced. Along with critical development issues such as climate change and resources degradation, what are the challenges ahead for teaching contemporary journalists? These were some of the issues explored by this panel at the Fourth World Journalism Education Congress (WJEC) conference in Auckland in July 2016. The panel was chaired by the Pacific Media Centre director Professor David Robie. Speakers were Emily Matasororo of the University of Papua New Guinea, Shailendra Singh of the University of the South Pacific, Misa Vicky Lepou of the National University of Samoa and Charlie David Mandavah of the Vanuatu Institute of Technology. Eliki Drugunalevu of the University of the South Pacific provided a summing up.
Cuidados de enfermagem no cateterismo cardíaco e angioplastia coronariana: desenvolvimento de um instrumento
Authors: Régis Ana Paula , Dalla Rosa Giovana Cristina , Lunelli Tatiana
Published: December 2017

Trata-se de uma pesquisa envolvendo os cuidados de enfermagem aos pacientes submetidos ao cateterismo e à angioplastia. Objetivou-se caracterizar os cuidados priorizados pelos enfermeiros da hemodinâmica. O estudo, que empregou o método quanti-qualitativo, explana as complicações, os riscos e os diagnósticos de enfermagem possíveis. Para sistematizar as duzentas e três respostas dos cinco enfermeiros questionados, as pesquisadoras elaboraram um check list, baseando-se nas etapas do processo de enfermagem. Os cuidados foram divididos em pré, trans e pós-procedimento e abrangeram desde checar a história alérgica do paciente até orientações de alta. As respostas dos enfermeiros possibilitaram à confirmação de alguns riscos, por exemplo, já apresentados na teoria, tais como hematoma e reestenose; além disso, outros não revelados nas literaturas utilizadas e que indicam a necessidade de novos estudos. Adequou-se a aplicação da sistematização da assistência de enfermagem através de um instrumento organizado de trabalho, conforme a realidade e a prática profissional.
A ludoterapia como ferramenta na assistência humanizada de enfermagem
Authors: Santos Solange Silva dos , Alves Andréia Barbosa da Silva , Oliveira Júlio Cesar , Gomes Alan , Maia Luiz Faustino dos Santos
Published: December 2017

O lúdico historicamente tem contribuído de modo significativo no âmbito educacional apresentado se de forma positiva na educação em saúde, como método de cuidados humanizado àqueles que estão no ambiente hospitalar ou domiciliar corroborando com a prevenção e recuperação de pacientes que necessitam de assistência integral ou parcial. O objetivo foi descrever a ludoterapia como parte do tratamento e recuperação de pessoas hospitalizadas. Para construção desse artigo foi utilizada como metodologia a revisão integrativa, com coleta de dados das seguintes bases: REDIB, SCIELO, LATINDEX, LILACS, CUIDEN, BDENF, utilizando-se os descritores: ludoterapia, hospitalização, assistência humanizada, enfermagem, a busca por publicados no período de 2009 a 2016. O enfermeiro necessita conhecer cientificamente as vantagens do lúdico e suas influencias desde a sua formação durante a academia. Aprender sobre o lúdico de maneira exploratória e difundir tais técnicas comas parte da assistência de enfermagem.
PROPOSTA DE AMBIENTAÇÃO DE INTERIORES PARA UMA MICROEMPRESA DE ORTOPEDIA: um estudo de caso em São Luís/MA
Authors: Cintra Myrian Gamita , Carvalhêdo Almeida Gylnara Kylma Feitosa , Guimarães Karoline De Lourdes Monteiro , Almeida Will Ribamar Mendes
Published: December 2017

O mercado de venda de produtos e serviços de ortopedia enfrenta a concorrência crescente e cada vez mais acirrada de empresas do setor. Neste contexto, propõe-se o desenvolvimento de uma pesquisa de cunho exploratório, cujo resultado final consiste na elaboração de uma proposta de ambientação de interiores que possibilite um ambiente confortável e que atenda as necessidades de funcionários e clientes neste ramo de negócio. Na pesquisa, foi estudada uma empresa em atividade localizada na região central da cidade de São Luís, Estado do Maranhão, que atua há muitos anos no mercado. Para a pesquisa, foi utilizado o método proposto pela arquiteta Mirian Gurgel, que parte da elaboração do perfil do cliente, para compor o programa de necessidades, seguido do estudo das características do espaço e geração de proposta, além do uso dos softwares AutoCAD para o desenvolvimento da planta de layout e Sketchup para a representação tridimensional da ambientação proposta. Os resultados alcançados com a aplicação do projeto mostraram que as necessidades identificadas foram atendidas.PALAVRAS-CHAVE: Loja de Ortopedia, Design de Interiores, Projeto de Ambientação.
PREDIÇÃO DO METABOLISMO DO CANDIDATO A FÁRMACO CINAMALDEÍDO: Uma abordagem in silico
Authors: Amorim Ítallo Patrick Sousa , Pestana Edgar Ramos , Mendes Saulo José Figueiredo
Published: December 2017

O objetivo do presente trabalho foi prever os prováveis sítios de metabolização e os prováveis metabólitos gerados do candidato a fármaco cinamaldeído (CNA) utilizando métodos in silico. Para isso, foram utilizadas duas plataformas virtuais, SMARTCyp e Metaprint2D-React. O SMARTCyp é uma plataforma online de previsão do metabolismo, ele usa algoritmos para fazer a previsão de metabolismo, porém estes algoritmos usam a energia de ativação do Citocromo P450. O Metaprint2D-React é uma plataforma virtual que usa algoritmos para prever os possíveis sítios de metabolismo de uma molécula. A previsão é feita a partir das reações de fase 1 (oxidação e redução) e 2 (conjugação). Para o Metaprint2D-React o principal sítio de metabolismo para o CNA foi a posição carbono 1, ainda, obteve-se os metabólitos gerados, a reação de redução gerou o composto álcool cinnamílico, já através da hidroxilação obteve-se o ácido cinâmico. O principal local de metabolização no SMARTCyp para o CNA foi o mesmo para o MetaPrint2D-React (Carbono 1), os locais de média e baixíssima chance de metabolização foram divergentes conforme o tipo de enzima do complexo enzimático do citocromo P450. Os resultados obtidos podem nortear outros estudos com o CNA, possibilitando a identificação de metabólitos e atuando no melhoramento químico a partir de diversas estratégias, como, por exemplo, o docking molecular. Ressalta-se que estudos in silico são de grande importância quando associados a outros tipos de estudos na Pesquisa e Desenvolvimento P&D de fármacos.PALAVRAS-CHAVE: toxicologia computacional; toxicocinética; planejamento de fármacos.
PENGARUH KEPEMILIKAN PUBLIK, PERTUMBUHAN PERUSAHAAN, DAN UKURAN KANTOR AKUNTAN PUBLIK TERHADAP PENGGANTIAN AUDITOR
Authors: Kristian Michelle
Published: December 2017

The issue of auditor’s independence is the main cause why the company is required to conduct mandatory penggantian auditor. Various questions arise when there are companies that perform voluntary penggantian auditor, the change of auditors outside thePeraturan Menteri Keuangan No. 17/PMK.01/2008. The purpose of this study is to test the effect of public ownership, company’s growth, and public accountant firm’s size towards penggantian auditor. The object of this study is Kompas100 Index company for period 2011-2013. Selection of the sample is determined based on purposive sampling method. The sample used in the study are 34 companies that are successively entered Kompas100 Index period 2011-2013 except for the financial sector, presenting financial statements in Indonesian Rupiah, has assets increased from year to year, and contains all data related to all variables. The data used in this study are secondary data, the annual financial statements audited by an independent auditor. Data analysis method used is logistic regression, as the dependent variable is non-metric and the independent variables are mixture of metric and non-metric. The results of this study are (1) public ownership does not affect penggantian auditor significantly, (2) company’s growth does not affect penggantian auditor significantly, (3) public accountant firm’s size does not affect penggantian auditor significantly, (4) public ownership, company’s growth, and public accountant firm’s size simultaneously do not affect penggantian auditor significantly.
Türkiye‘de Besiye Alınan Simmental, Aberdeen Angus, Hereford, Limousin ve Charolais Irkı Sığırların Besi Performansı ve Karkas Özellikleri
Authors: Duru Serdar , Sak Halil
Published: December 2017

Bu araştırmada, Simmental (SİM), Aberdeen Angus (ANG), Hereford (HER), Limousin (LİM) ve Charolais (CHA) ırkı sığırların besi performansı ve karkas özelliklerinin belirlenmesi amaçlanmıştır. Uruguay ve Fransa‘dan 2015 yılında ithal edilen 10-12 aylık yaştaki 606 baş erkek sığır kullanılmıştır. Tüm hayvanlar yaklaşık 7-9 ay süren besi süresinde aynı rasyon ile sınırsız beslenmişlerdir. Hayvanlar Nisan-Haziran 2016 arasında kesilmişlerdir. Varyans analizi sonucunda ırk, besi başı ağırlığı (BBA) ve besi süresi (BS) incelenen özelliklerin çoğu üzerine etkileri önemli (P