bluuebunny/crossref_metadata_2025 huggingface dataset:
Community-Centric Approaches to Coastal Hazard Assessment and Management in Southside Norfolk, Virginia, USA
Authors: Ismael Dalya , Hutton Nicole , Erten-Unal Mujde , Considine Carol , Vandecar-Burdin Tancy , Davis Christopher , Chen Yin-Hsuen
Published: March 2024

Urban communities in environmentally sensitive areas face escalating challenges due to climate change and inadequate infrastructural support, particularly in underserved regions like southside Norfolk, Virginia. This area, characterized by its vulnerability to flooding and a predominantly low-income population, lacks equitable inclusion in broader urban flood protection plans. This research focuses on the development of community-centered resilience strategies through active engagement and collaboration with local residents. The methodology centered around building trust and understanding within the community through a series of interactions and events. This approach facilitated a two-way exchange of information, enabling the research team to gather crucial insights on community-valued assets, prevalent flooding issues, and preferred flood mitigation solutions. The engagement revealed a significant increase in community knowledge regarding climate change, sea level rise, and stormwater management. Residents expressed a strong preference for green infrastructure solutions, including rain gardens, permeable pavements, and living shorelines, alongside concerns about pollution and the need for infrastructure redesign. The outcomes of this community engagement have initiated plans to develop tailored, nature-based flooding solutions. These results are set to inform future urban planning and policy, offering insights to the City of Norfolk and the United States Army Corps of Engineers for potential redesigns of flood intervention strategies that are more inclusive and effective. A template for participatory research to inform coastal hazard management includes cross-sector collaboration, a long-term engagement commitment, and education and surveying opportunities to align solutions to lived, local experiences. This template allows for community trust building, which is especially important in environmental justice communities. The study highlights the importance of community involvement in urban resilience planning, demonstrating that local engagement is essential in shaping community-centric solutions and equitable environmental policies.
Modulation of the Madden–Julian Oscillation Center Stagnation on Typhoon Genesis over the Western North Pacific
Authors: Lin Chun-qiao , Fan Ling-li , Chen Xu-zhe , Li Jia-Hao , Xu Jian-jun
Published: March 2024

Madden–Julian Oscillation (MJO) modulates the generation of typhoons (TYs) in the western North Pacific (WNP). Using IBTrACS v04 tropical cyclone best path data, ERA5 reanalysis data, and the MJO index from the Climate Prediction Center (CPC), this paper defines an index to describe the persistent anomalies of the MJO and to examine the statistical characteristics of TYs over 44 years (1978–2021), focusing on the analysis of major differences in environmental conditions after the removal of the ENSO signal over the WNP. The results indicate that the persistent anomalous state of the MJO influences the change in large-scale environmental factors, which, in turn, affects the generation of TYs, as follows: (1) For the I high-value years, the center of the MJO stagnates in the Indian Ocean–South China Sea (SCS), the monsoon trough retreats westward, the warm pool becomes warmer, and the Walker circulation is enhanced. There is stronger upper-level divergence and low-level convergence, larger low-level relative vorticity, higher mid-level relative humidity, and smaller vertical wind shear in the SCS and the seas near the Philippines. Consequently, these conditions foster a conducive environment for TY genesis in the SCS and the seas near the Philippines. (2) For the I low-value years, the center of the MJO stagnates in the WNP–North America region, the monsoon trough extends eastward, the warm pool becomes colder, and the Walker circulation is weakened. Consequently, these conditions are more likely to facilitate TY genesis in the central–eastern WNP. The results show that persistent anomalies in MJO active centers can effectively improve the predictive ability of TY frequency.
Approximate and Parametric Solutions to SIR Epidemic Model
Authors: Bougoffa Lazhar , Bougouffa Smail , Khanfer Ammar
Published: March 2024

This article provides a detailed exploration of the SIR epidemic model, starting with its meticulous formulation. The study employs a novel approach called the upper and lower bounds technique to approximate the solution to the SIR model, providing insights into the dynamic interplay between susceptible S, infected I, and recovered R populations. A new parametric solution to this model has been presented. Applying the Adomian decomposition method (ADM) allows for the attaining of highly accurate approximate solutions in the context of the SIR epidemic model. To validate the accuracy and robustness of the proposed approach, a numerical exploration is conducted, considering a diverse range of experimental parameters. This numerical analysis provides valuable insights into the sensitivity and responsiveness of the SIR epidemic model under varying conditions, contributing to the broader understanding of infectious disease dynamics. The interplay between theoretical formulation and numerical exploration establishes a comprehensive framework for studying the SIR model, with implications for refining our ability to predict and manage the spread of infectious diseases.
On the Two-Variable Analogue Matrix of Bessel Polynomials and Their Properties
Authors: Bakhet Ahmed , Hussain Shahid , Niyaz Mohamed , Zakarya Mohammed , AlNemer Ghada
Published: March 2024

In this paper, we explore a study focused on a two-variable extension of matrix Bessel polynomials. We initiate the discussion by introducing the matrix Bessel polynomials involving two variables and derive specific differential formulas and recurrence relations associated with them. Additionally, we present a segment detailing integral formulas for the extended matrix Bessel polynomials. Lastly, we introduce the Laplace–Carson transform for the two-variable matrix Bessel polynomial analogue.
Estrogen and Progesterone Receptors Are Dysregulated at the BPH/5 Mouse Preeclamptic-Like Maternal–Fetal Interface
Authors: Gomes Viviane C. L. , Gilbert Bryce M. , Bernal Carolina , Crissman Kassandra R. , Sones Jenny L.
Published: March 2024

The etiopathogenesis of preeclampsia, a leading hypertensive disorder of pregnancy, has been proposed to involve an abnormal circulating sex hormone profile and misexpression of placental estrogen and progesterone receptors (ER and PR, respectively). However, existing research is vastly confined to third trimester preeclamptic placentas. Consequently, the placental–uterine molecular crosstalk and the dynamic ER and PR expression pattern in the peri-conception period remain overlooked. Herein, our goal was to use the BPH/5 mouse to elucidate pre-pregnancy and early gestation Er and Pr dynamics in a preeclamptic-like uterus. BPH/5 females display low circulating estrogen concentration during proestrus, followed by early gestation hypoestrogenemia, hyperprogesteronemia, and a spontaneous preeclamptic-like phenotype. Preceding pregnancy, the gene encoding Er alpha (Erα, Esr1) is upregulated in the diestrual BPH/5 uterus. At the peak of decidualization, Esr1, Er beta (Erβ, Esr2), and Pr isoform B (Pr-B) were upregulated in the BPH/5 maternal–fetal interface. At the protein level, BPH/5 females display higher percentage of decidual cells with nuclear Erα expression, as well as Pr downregulation in the decidua, luminal and glandular epithelium. In conclusion, we provide evidence of disrupted sex hormone signaling in the peri-conception period of preeclamptic-like pregnancies, potentially shedding some light onto the intricate role of sex hormone signaling at unexplored timepoints of human preeclampsia.
Phytochemical, Pharmacological, and Molecular Docking Study of Dry Extracts of Matricaria discoidea DC. with Analgesic and Soporific Activities
Authors: Sepp Janne , Koshovyi Oleh , Jakštas Valdas , Žvikas Vaidotas , Botsula Iryna , Kireyev Igor , Severina Hanna , Kukhtenko Oleksandr , Põhako-Palu Kaisa , Kogermann Karin , Heinämäki Jyrki , Raal Ain
Published: March 2024

Pineapple weed (Matricaria discoidea DC.) is a widespread plant in Europe and North America. In ethnomedicine, it is well-known for its anti-inflammatory and spasmolytic activities. The aim of this research was to develop novel methods of M. discoidea processing to obtain essential oil and dry extracts and to investigate their phytochemical compositions. Moreover, the molecular docking of the main substances and the in vivo studies on their soporific and analgesic activities were conducted. The essential oil and two dry extracts from M. discoidea were prepared. A total of 16 phenolic compounds (seven flavonoids, seven hydroxycinnamic acids, and two phenolic acids) in the dry extracts were identified by means of UPLC-MS/MS. In the essential oil, nine main terpenoids were identified by gas chromatography (GC). It was shown that phenolic extraction from the herb was successful when using 70% ethanol in a triple extraction method and at a ratio of 1:14–1:16. The in vivo studies with rodents demonstrated the analgesic activity of the M. discoidea extracts and improvements in the sleep of animals. The dry extracts of M. discoidea did not show any toxicity. The molecular docking analysis showed a high probability of COX-1,2 inhibition and NMDA receptor antagonism by the extracts.
Performance of Radiological and Biochemical Biomarkers in Predicting Radio-Symptomatic Knee Osteoarthritis Progression
Authors: Almhdie-Imjabbar Ahmad , Toumi Hechmi , Lespessailles Eric
Published: March 2024

Imaging biomarkers permit improved approaches to identify the most at-risk patients encountering knee osteoarthritis (KOA) progression. This study aimed to investigate the utility of trabecular bone texture (TBT) extracted from plain radiographs, associated with a set of clinical, biochemical, and radiographic data, as a predictor of long-term radiographic KOA progression. We used data from the Foundation for the National Institutes of Health (FNIH) Biomarkers Consortium dataset. The reference model made use of baseline TBT parameters adjusted for clinical covariates and radiological scores. Several models based on a combination of baseline and 24-month TBT variations (TBT∆TBT) were developed using logistic regression and compared to those based on baseline-only TBT parameters. All models were adjusted for baseline clinical covariates, radiological scores, and biochemical descriptors. The best overall performances for the prediction of radio-symptomatic, radiographic, and symptomatic progression were achieved using TBT∆TBT parameters solely, with area under the ROC curve values of 0.658 (95% CI: 0.612–0.705), 0.752 (95% CI: 0.700–0.804), and 0.698 (95% CI: 0.641–0.756), respectively. Adding biochemical markers did not significantly improve the performance of the TBT∆TBT-based model. Additionally, when TBT values were taken from the entire subchondral bone rather than just the medial, lateral, or central compartments, better results were obtained.
The Use and Potential Benefits of N-Acetylcysteine in Non-Acetaminophen Acute Liver Failure: An Etiology-Based Review
Authors: Popescu Mihai , Bratu Angelica , Agapie Mihaela , Borjog Tudor , Jafal Mugurel , Sima Romina-Marina , Orban Carmen
Published: March 2024

Acute liver failure represents a life-threatening organ dysfunction with high mortality rates and an urgent need for liver transplantation. The etiology of the disease varies widely depending on various socio-economic factors and is represented mainly by paracetamol overdose and other drug-induced forms of liver dysfunction in the developed world and by viral hepatitis and mushroom poisoning in less developed countries. Current medical care constitutes either specific antidotes or supportive measures to ensure spontaneous recovery. Although it has been proven to have beneficial effects in paracetamol-induced liver failure, N-acetylcysteine is widely used for all forms of acute liver failure. Despite this, few well-designed studies have been conducted on the assessment of the potential benefits, dose regimens, or route of administration of N-acetylcysteine in non-acetaminophen liver failure. This review aims to summarize the current evidence behind the use of this drug in different forms of liver failure.
Infratentorial Relapsing Neuroglial Tumors in Adults: Management and Unsolved Issues—A Systematic Review
Authors: Brunasso Lara , Avallone Chiara , Florena Ada Maria , Grasso Giovanni
Published: March 2024

(1) Background: Gangliogliomas are rare tumors accounting for about 0.4% of all central nervous system tumors. They are usually located in the temporal lobes of children and young adults, though such tumors in the infratentorial region and adult-age patients rarely reported. (2) Methods: A systematic review on ganglioglioma with infratentorial location in the adult population was conducted in accordance with the PRISMA guidelines. A total of 275 articles were found, and 23 were included. Demographic data, the location and histology of the lesion, pre-operative neurological status, the type of surgery, recurrence, radiotherapy/chemotherapy adjuvant treatments, neurological outcomes and follow-up information were collected. We also presented an illustrative case. (3) Results: A total of 27 patients were included. In 51%, the location was the cerebellum; in 40%, it was the fourth ventricle; in 11%, it was brainstem; and in 4%, it was the cerebellopontine angle. STR was performed in 44%, GTR in 26% and biopsy in 15% of the cases. Adjuvant radiotherapy was found in 22% of cases. Disease recurrence occurred in 15% of patients between 1 and 12 months after surgery with a diagnosis of high-grade ganglioglioma, while in six cases, no disease recurrence was documented. (4) Conclusions: Infratentorial glioneuronal tumors are rare findings in the adult population. Histopathological characterization does not seem to fully reflect their true behavior. Future studies are warranted for better characterizing histopathological findings and treatment.
Correction: Hansen et al. Persisting Verbal Memory Encoding and Recall Deficiency after mGluR5 Autoantibody-Mediated Encephalitis. Brain Sci. 2023, 13, 1537
Authors: Hansen Niels , Rentzsch Kristin , Hirschel Sina , Wiltfang Jens , Schott Björn H. , Malchow Berend , Bartels Claudia
Published: March 2024

Affiliations: In the published publication [...]
A GIS-Based Top-Down Approach to Support Energy Retrofitting for Smart Urban Neighborhoods
Authors: Ahmed Wahhaj , Al-Ramadan Baqer , Asif Muhammad , Adamu Zulfikar
Published: March 2024

Energy and environmental challenges are a major concern across the world and the urban residential building sector, being one of the main stakeholders in energy consumption and greenhouse gas emissions, needs to be more energy efficient and reduce carbon emissions. While it is easier to design net zero energy homes, existing home stocks are a major challenge for energy retrofitting. Two key challenges are determining the extent of retrofitting required, and developing knowledge-based effective policies that can be applied en-masse to housing stocks and neighborhoods. To overcome these challenges, it is essential to gather critical data about qualities of existing buildings including their age, geo-location, construction type, as well as electro-mechanical and occupancy parameters of each dwelling. The objective of this study was to develop a GIS-based model embedded with critical data of residential buildings to facilitate evidence-based retrofit programs for urban neighborhoods. A model based on a bottom-up approach was proposed in which information gathered from all stakeholders was inputted into one database that can be used for decision-making. A geo-located case study to validate a proposed GIS-based residential retrofitting model sample size of 74 residential buildings in the city of Riyadh was statistically analyzed and used. The results indicate behavior-based patterns, with a strong positive correlation (r = 0.606) between the number of occupants and number of household appliances, while regression analysis showed high occupancy rates do not necessarily result in high utility costs at the end of the month, and there is no statistical difference in the average monthly cost of gas between partial and fully occupied houses. Furthermore, neither the type of building, height, age, nor occupancy status play a significant role in the average energy consumed. Additionally, the GIS-based model was validated and found to be effective for energy-use mapping and gathering critical data for analyzing energy consumption patterns at neighborhood scale, making it useful for municipalities to develop effective policies aimed at energy efficient and smart neighborhoods, based on a recommended list of most effective energy-saving retrofit measures.
Experimental Analysis of the Influence of Seasonality on the Temperature Regime of Extensive Roofs in Central Europe
Authors: Chabada Marek , Durica Pavol , Juras Peter
Published: March 2024

Current building envelope greening systems are not just areas covered with vegetation. Today’s systems can maximise the functional contribution of vegetation to a building’s performance and become part of a sustainable urban renewal strategy. The impact of the vegetation layer directly affects the building in its immediate vicinity, from the outside, while also having a significant impact on the indoor environment. Green roofs are the most widespread vegetated structures worldwide. This paper aims to demonstrate the behaviour of the temperature regime of an extensive green roof over a production hall and an administrative area in comparison to that of a roof without vegetation cover. In evaluating the results, a period with weather representative of winter and summer was selected to show the importance of seasonality. The fact that this is a new building, and that the extensive roof is not fully covered with vegetation, is very well reflected in the results, as the absence of a vegetated area significantly affects the temperature of as well as the heat flux through the roof structure. The dark colour of the substrate absorbs significantly more solar radiation than the light surface of the waterproofing, resulting in an increase in temperature and heat flux into the structure.
Evaluating Airborne Sound Insulation in Dwellings Constructed with Hollow Ceramic Blocks under Brazilian Housing Policies
Authors: Scoczynski Ribeiro Rodrigo , Arnela Marc , Braz-César Manuel Teixeira , Bosse Rúbia Mara , Silvestro Laura , Gidrão Gustavo de Miranda Saleme , Kempka Mariane , Silva Dyorgge Alves , Farias Czap Marcela Maier
Published: March 2024

In Brazil, there is a shortage of approximately 5.80 million residences, a challenge that intensified during the pandemic. Since 2013, there has been a mandate to implement specific performance criteria in residential constructions. However, many construction firms face difficulties in meeting these standards, especially concerning sound insulation in partition elements. This work aims to assess the airborne sound insulation performance and compliance with legal standards in new residential buildings through measurements and simulations. In particular, subsidized housing units for low-income populations are studied, which are eligible for reduced taxes on building loans. These buildings are typically made of hollow ceramic blocks with vertical perforations as separating walls, a commonly used national building material. Three buildings located in Guarapuava, a southern city in Brazil with a population of approximately 183,000 residents, were selected for this purpose. Measurements were conducted following ISO 16283-1 guidelines, whereas simulations were performed using ISO 12354-1, initially assuming a uniform plate but also exploring an alternative model that considers orthotropic behavior with analytical expressions. The calculations considered both static and dynamic moduli of elasticity. The results indicated that all the units failed to meet the specified standards. The measured DnT,w values were below the required thresholds, obtaining 42 < 45 dB for Building B1, 40 < 45 dB for Building B2, and 38 < 40 dB for Building B3. The predicted DnT,w values agreed well with the measured values when considering orthotropy with a dynamic elastic modulus. However, discrepancies were observed in the spectral analysis, especially at lower and higher frequencies. The findings suggest refraining from employing single-leaf partition walls made of vertical hollow ceramic blocks in such buildings. Improving sound insulation necessitates embracing a comprehensive strategy that takes into account the separating element, flanking paths, and the room geometries.
Enhanced Documentation and Evaluation of Grouting Process, through the Fusion of Non-Destructive Testing and Evaluation Information—The Case Study of the Katholikon of the Monastery of Panagia Varnakova
Authors: Roumeliotis Stergios , Lampropoulos Kyriakos , Delegou Ekaterini , Tsilimantou Elisavet , Keramidas Vasileios , Bakolas Asterios , Moropoulou Antonia
Published: March 2024

The restoration of historic buildings and structures involves a wide range of scientific and technical fields. The grouting process is among an array of rehabilitation and preservation interventions and aims to homogenize the structure after the implementation of strengthening measures. The process can provide important information regarding the state of preservation of the examined structure and correlate the progress of the process with the pathology of the monument. To achieve this, the analysis of typical raw grouting data is progressively fused with additional information from the diagnostic studies, non-destructive testing, geospatial information, and from the calculation and analysis of grouting indices. The restoration project of the Katholikon of the Monastery of Panagia Varnakova in Fokida, Greece was selected as the case study, due to its large scale and the severe earthquake damage it has sustained, which has necessitated comprehensive strengthening interventions and extensive grouting. The implementation of an integrated methodological approach validated the enhanced level of co-analysis, revealing information that is not readily deduced from a typical approach. Selected sub-areas of the Katholikon are presented, demonstrating how the observed pathology can be correlated with the results of the grouting process, while incorporating 3D data, and findings from structural and non-destructive analyses.
Comparative Study of the Performance of Underwater Concrete between Anionic and Nonionic Anti-Washout Admixtures
Authors: Song Xiaoyun , Zheng Heping , Xu Lei , Xu Tingting , Li Qiuyu
Published: March 2024

An investigation was carried out to study the influence of two types of anti-washout admixtures (AWAs) on the performance of underwater concrete, specifically, workability and washout resistance. The tested AWAs were hydroxypropyl methylcellulose (HPMC) and polyacrylamide (PAM) as nonionic AWAs and carboxymethyl starch (CMS) and polyanionic cellulose (PAC) as anionic AWAs. Rheological properties (slump and slump flow), washout resistance, and compressive strength were measured to evaluate the properties of the fresh and hardened concrete. The results indicate that anionic AWAs are more effective at improving workability and strength than nonionic AWAs in anti-washout underwater concrete. When the nonionic AWA dosage exceeded 0.3% (W/C = 0.45), the fluidity and air content were negatively impacted. Additionally, nonionic AWAs more readily alter the morphological structure of cement paste, affecting cement particle hydration and underwater concrete properties. Regarding the mechanical properties, compared with those of concrete without AWAs and with nonionic AWAs, the 28-day compressive strength of concrete with anionic AWAs reached 37 MPa, an increase of 151% and 131%, respectively. Compared with nonionic AWAs, concrete with anionic AWAs is more stable.
Research on Prediction of EPB Shield Tunneling Parameters Based on LGBM
Authors: Wang Wei , Feng Huanhuan , Li Yanzong , You Quanwei , Zhou Xu
Published: March 2024

At present, the determination of tunnel parameters mainly rely on engineering experience and human judgment, which leads to the subjective decision of parameters and an increased construction risk. Machine learning algorithms could provide an objective theoretical basis for tunnel parameter decision making. However, due to the limitations of a machine learning model’s performance and parameter selection methods, the prediction model had poor prediction results and low reliability for parameter research. To solve the above problems, based on a large number of construction parameters of a composite section subway in Shenzhen, this paper combined dimensionality reduction data with service analysis to optimize the selection process of shield tunneling parameters, and determined the total propulsion force, cutter head torque, cutter head speed, and advance rate as key tunneling parameters. Based on an LGBM algorithm and Bayesian optimization, the prediction model of key tunneling parameters of an earth pressure balance shield was established. The results showed that the average error of the LGBM model on the test set was 8.18%, the average error of the cutter head torque was 13.93%, the average error of the cutter head speed was 3.16%, and the average error of advance rate was 13.35%. Compared with the RF model, the prediction effect and the generalization on the test set were better. Therefore, an LGBM algorithm could be used as an effective prediction method for tunneling parameters in tunnel construction and provide guidance for the setting of tunneling parameters.
Emerging Advances in Endometrial Cancer: Integration of Molecular Classification into Staging for Enhanced Prognostic Accuracy and Implications for Racial Disparities
Authors: Ogunmuyiwa Joy , Williams Vonetta
Published: March 2024

Since the 2009 FIGO staging update, focused exclusively on the anatomic extent of disease, there have been several advances in the understanding of the pathologic and molecular features of endometrial cancer. In a significant departure from the 2009 FIGO staging system, the 2023 FIGO staging update integrates both histopathological and molecular classification. With the inclusion of non-anatomic pathologic parameters such as histology, tumor grade, lymphovascular space invasion, and molecular subtype, the 2023 FIGO staging update aims to create more clinically relevant substages that improve prognostic value and allows for more individualized treatment paradigms. This review will evaluate the clinical impact of the 2023 FIGO staging update, describe the stage shifts that lead to higher prognostic precision, and illustrate the current state of molecular analysis in clinical practice. Furthermore, this review will explore how incorporating factors such as molecular subtype into endometrial cancer staging can offer valuable insights into the racial disparities seen in morbidity and mortality.
Correction: Huang et al. Systemic Anticoagulation and Inpatient Outcomes of Pancreatic Cancer: Real-World Evidence from U.S. Nationwide Inpatient Sample. Cancers 2023, 15, 1985
Authors: Huang Yen-Min , Shih Hsuan-Jen , Chen Yi-Chan , Hsieh Tsan-Yu , Ou Che-Wei , Su Po-Hsu , Chen Shih-Ming , Zheng Yun-Cong , Hsu Li-Sung
Published: March 2024

In the original publication [...]
Ru/Attapulgite as an Efficient and Low-Cost Ammonia Decomposition Catalyst
Authors: Teng Qingfeng , Sang Junkang , Chen Guoxin , Tao Haoliang , Wang Yunan , Li Hua , Guan Wanbing , Ding Changsheng , Liu Fenghua , Zhu Liangzhu
Published: March 2024

On-site hydrogen generation from ammonia decomposition is a promising technology to address the challenges of direct transportation and storage of hydrogen. The main problems with the existing support materials for ammonia decomposition catalysts are their high cost and time-consuming preparation process. In this work, ammonia decomposition catalysts consisting of in situ-formed nano-Ru particles supported on a naturally abundant mineral fiber, attapulgite (ATP), were proposed and studied. Also, 1 wt.% Ru was uniformly dispersed and anchored onto the surface of ATP fibers via the chemical method. We found that the calcination temperatures of the ATP support before the deposition of Ru resulted in little difference in catalytic performance, while the calcination temperatures of the 1Ru/ATP precursor were found to significantly influence the catalytic performance. The prepared 1 wt.% Ru/ATP catalyst (1Ru/ATP) without calcination achieved an ammonia conversion efficiency of 51% at 500 °C and nearly 100% at 600 °C, with the flow rate of NH3 being 10 sccm (standard cubic centimeter per minute). A 150 h continuous test at 600 °C showed that the 1Ru/ATP catalyst exhibited good stability with a degradation rate of about 0.01% h−1. The 1Ru/ATP catalyst was integrated with proton ceramic fuel cells (PCFCs). We reported that PCFCs at 650 °C offered 433 mW cm−2 under H2 fuel and 398 mW cm−2 under cracked NH3 fuel. The overall results suggest low-level Ru-loaded ATP could be an attractive, low-cost, and efficient ammonia decomposition catalyst for hydrogen production.
Hydrodesulfurization of Thiophene in n-Heptane Stream Using CoMo/SBA-15 and CoMo/AlSBA-15 Mesoporous Catalysts
Authors: Coutinho Ana Carla S. L. S. , Barros Joana M. F. , Araujo Marcio D. S. , Silva Jilliano B. , Souza Marcelo J. B. , Delgado Regina C. O. B. , Fernandes Jr. Valter J. , Araujo Antonio S.
Published: March 2024

Heterogeneous catalysts containing cobalt and molybdenum supported on mesoporous materials types SBA-15 and AlSBA-15 were synthesized for application in the HDS reactions of thiophene in the n-heptane stream. The materials were synthesized by the hydrothermal method using Pluronic P123 as a template. The calcined SBA-15 and AlSBA-15 supports were submitted to co-impregnation with solutions of cobalt nitrate and ammonium heptamolybdate, aiming for the production of 15% in mass of metal loading with an atomic ratio of [Co/(Co + Mo)] = 0.45. The obtained materials were dried and calcined to obtain the mesoporous catalysts in the forms of CoMo/SBA-15 and CoMo/AlSBA-15. The catalysts were characterized by XRD, TG/DTG, SEM, and nitrogen adsorption. From XRD analysis, it was verified that after the decomposition of the cobalt and molybdenum salts, MoO3, Co3O4, and CoMoO4 oxides were formed on the supports, being attributed to these chemical species, the activity for the HDS reactions. The catalytic activity of the obtained catalysts was evaluated in a continuously flowing tubular fixed-bed microreactor coupled on-line to a gas chromatograph, using an n-heptane stream containing 12,070 ppm of thiophene (ca. 5100 ppm of sulfur) as a model compound. The synthesized catalysts presented suitable activity for the HDS reaction, and the main obtained products were cis- and trans-2-butene, 1-butene, n-butane, and low amounts of isobutane. The presence of 1,3-butadiene and tetrahydrothiophene (THT) was not detected. A mechanism of the primary and secondary reactions and subsequent formation of the olefins and paraffins in the CoMo/SBA-15 and CoMo/AlSBA-15 mesoporous catalysts was proposed, considering steps of desulfurization, hydrogenation, dehydrogenation, THT decyclization, and isomerization.
Kinetic and Mechanistic Study of Aldose Conversion to Functionalized Furans in Aqueous Solutions
Authors: Warthegau Stefan S. , Karlsson Magnus , Madsen Robert , Jensen Pernille Rose , Meier Sebastian
Published: March 2024

Reaction mixtures of naturally abundant aldoses and CH nucleophiles allow for the formation of functionalized furan precursors using low temperatures and metal-free catalysis in aqueous solutions of dilute base catalysts. We employ in situ NMR assays to clarify the mechanism and kinetics of the conversion. Catalysis serves a double role in ring-opening of stable aldoses such as glucose and xylose and facilitating the subsequent reactions with CH acids such as malononitrile or cyanoacetamide. Resultant acyclic products are shown to convert quickly to a monocyclic product prior to the slower formation of a more stable bicyclic intermediate and dehydration to tri-functionalized furan. Especially the reversible 5-exo-dig ring closure entailing oxygen attack onto a nitrile carbon is surprisingly fast with an equilibrium vastly towards the cyclic state, sequestering reactive groups and allowing the selective conversion to tri-functionalized furan. The reaction hinges on the fast formation of intermediates without CH acidity and competes with the oligomerization of CH nucleophiles. Insight derived from in situ NMR analysis shows the prowess of high-resolution in situ spectroscopy in clarifying the interplay between catalysts and reactants. Such insight will be vital for the optimization of reactions that upgrade biorenewables under benign conditions.
Unique Spatial Transcriptomic Profiling of the Murine Femoral Fracture Callus: A Preliminary Report
Authors: Jiang Will , Caruana Dennis L. , Back Jungho , Lee Francis Y.
Published: March 2024

Fracture callus formation is a dynamic stage of bone activity and repair with precise, spatially localized gene expression. Metastatic breast cancer impairs fracture healing by disrupting bone homeostasis and imparting an altered genomic profile. Previous sequencing techniques such as single-cell RNA and in situ hybridization are limited by missing spatial context and low throughput, respectively. We present a preliminary approach using the Visium CytAssist spatial transcriptomics platform to provide the first spatially intact characterization of genetic expression changes within an orthopedic model of impaired fracture healing. Tissue slides prepared from BALB/c mice with or without MDA-MB-231 metastatic breast cancer cells were used. Both unsupervised clustering and histology-based annotations were performed to identify the hard callus, soft callus, and interzone for differential gene expression between the wild-type and pathological fracture model. The spatial transcriptomics platform successfully localized validated genes of the hard (Dmp1, Sost) and soft callus (Acan, Col2a1). The fibrous interzone was identified as a region of extensive genomic heterogeneity. MDA-MB-231 samples demonstrated downregulation of the critical bone matrix and structural regulators that may explain the weakened bone structure of pathological fractures. Spatial transcriptomics may represent a valuable tool in orthopedic research by providing temporal and spatial context.
Potential Utility of Urinary Follistatin as a Non-Invasive Indicator of Acute Tubular Damage in Patients with Acute Kidney Injury
Authors: Nagayama Izumi , Takayanagi Kaori , Nagata Daisuke , Hasegawa Hajime , Maeshima Akito
Published: March 2024

Activin A is known to impede tubular repair following renal ischemia, whereas exogenous follistatin, an activin A antagonist, has been shown to ameliorate kidney damage in rats. Despite these findings, the precise role of endogenous follistatin in the kidney has yet to be elucidated. In this study, we investigated the localization of follistatin in the normal human kidney and its potential utility as a marker for acute kidney injury (AKI). In a total of 118 AKI patients and 16 healthy adults, follistatin levels in serum and urine were quantified using ELISA, and correlations with clinical parameters were analyzed. Follistatin-producing cells were positive for Na-Cl co-transporter and uromodulin, but negative for aquaporin 1 and aquaporin 2. Unlike healthy adults, urinary follistatin significantly increased in AKI patients, correlating positively with AKI severity. Urinary follistatin levels were notably higher in patients needing renal replacement therapy. Significant correlations were observed with urinary protein, α1 microglobulin, and urinary NGAL, but not with urinary KIM-1, urinary L-FABP, urinary NAG, urinary β2 microglobulin, or serum creatinine. Interestingly, no correlation between urinary and serum follistatin levels was identified, indicating a renal origin for urinary follistatin. In conclusion, follistatin, produced by distal tubules, is detectable in the urine of AKI patients, suggesting its potential as a valuable marker for monitoring acute tubular damage severity in AKI.
Effects of Diabetes Mellitus on Corneal Immune Cell Activation and the Development of Keratopathy
Authors: Surico Pier Luigi , Narimatsu Akitomo , Forouzanfar Katayoon , Singh Rohan Bir , Shoushtari Sara , Dana Reza , Blanco Tomas
Published: March 2024

Diabetes mellitus (DM) is one of the most prevalent diseases globally, and its prevalence is rapidly increasing. Most patients with a long-term history of DM present with some degree of keratopathy (DK). Despite its high incidence, the underlying inflammatory mechanism of DK has not been elucidated yet. For further insights into the underlying immunopathologic processes, we utilized streptozotocin-induced mice to model type 1 DM (T1D) and B6.Cg-Lepob/J mice to model type 2 DM (T2D). We evaluated the animals for the development of clinical manifestations of DK. Four weeks post-induction, the total frequencies of corneal CD45+CD11b+Ly-6G− myeloid cells, with enhanced gene and protein expression levels for the proinflammatory cytokines TNF-α and IL-1β, were higher in both T1D and T2D animals. Additionally, the frequencies of myeloid cells/mm2 in the sub-basal neural plexus (SBNP) were significantly higher in T1D and T2D compared to non-diabetic mice. DK clinical manifestations were observed four weeks post-induction, including significantly lower tear production, corneal sensitivity, and epitheliopathy. Nerve density in the SBNP and intraepithelial terminal endings per 40x field were lower in both models compared to the normal controls. The findings of this study indicate that DM alters the immune quiescent state of the cornea during disease onset, which may be associated with the progressive development of the clinical manifestations of DK.
A Systematic Review of Automated Construction Inspection and Progress Monitoring (ACIPM): Applications, Challenges, and Future Directions
Authors: Samsami Reihaneh
Published: March 2024

Despite the subjective and error-prone nature of manual visual inspection procedures, this type of inspection is still a common process in most construction projects. However, Automated Construction Inspection and Progress Monitoring (ACIPM) has the potential to improve inspection processes. The objective of this paper is to examine the applications, challenges, and future directions of ACIPM in a systematic review. It explores various application areas of ACIPM in two domains of (a) transportation construction inspection, and (b) building construction inspection. The review identifies key ACIPM tools and techniques including Laser Scanning (LS), Uncrewed Aerial Systems (UAS), Robots, Radio Frequency Identification (RFID), Augmented Reality (AR), Virtual Reality (VR), Computer Vision (CV), Deep Learning, and Building Information Modeling (BIM). It also explores the challenges in implementing ACIPM, including limited generalization, data quality and validity, data integration, and real-time considerations. Studying legal implications and ethical and social impacts are among the future directions in ACIPM that are pinpointed in this paper. As the main contribution, this paper provides a comprehensive understanding of ACIPM for academic researchers and industry professionals.
Application Research of Ultrasonic-Guided Wave Technology in Pipeline Corrosion Defect Detection: A Review
Authors: Lyu Feng , Zhou Xinyue , Ding Zheng , Qiao Xinglong , Song Dan
Published: March 2024

This paper presents research on the application of ultrasonic-guided wave technology in corrosion defect identification, expounds the relevant ultrasonic-guided wave theories and the principle of ultrasonic-guided wave non-destructive testing of pipelines, and discusses the Lamb wave and shear horizontal wave mode selection that is commonly used in ultrasonic-guided wave corrosion detection. Furthermore, research progress in the field of ultrasonic-guided wave non-destructive testing (NDT) technology, i.e., regarding transducers, structural health monitoring, convolutional neural networks, machine learning, and other fields, is reviewed. Finally, the future prospects of ultrasonic-guided wave NDT technology are discussed.
The Role and Value of Professional Rapid Testing of Acute Respiratory Infections (ARIs) in Europe: A Special Focus on the Czech Republic, Poland, and Romania
Authors: Drevinek Pavel , Flisiak Robert , Nemes Roxana , Nogales Crespo Katya A. , Tomasiewicz Krzysztof
Published: March 2024

This review aims to explore the role of professional diagnostic rapid testing of acute respiratory infections (ARIs), especially COVID-19 and influenza, ensuring proper disease management and treatment in Europe, and particularly in Czech Republic, Poland, and Romania. The paper was constructed based on a review of scientific evidence and national and international policies and recommendations, as well as a process of validation by four experts. The development of new testing technologies, treatment options, and increased awareness of the negative multidimensional impact of ARI profiles transformed differential diagnosis into a tangible and desirable reality. This review covers the following topics: (1) the multidimensional impact of ARIs, (2) ARI rapid diagnostic testing platforms and their value, (3) the policy landscape, (4) challenges and barriers to implementation, and (5) a set of recommendations illustrating a path forward. The findings indicate that rapid diagnostic testing, including at the point of care (POC), can have a positive impact on case management, antimicrobial and antibiotic stewardship, epidemiological surveillance, and decision making. Integrating this strategy will require the commitment of governments and the international and academic communities, especially as we identified room for improvement in the access and expansion of POC rapid testing in the focus countries and the inclusion of rapid testing in relevant policies.
A Web-Based Dynamic Nomogram to Predict the Risk of Methicillin-Resistant Staphylococcal Infection in Patients with Pneumonia
Authors: Duong-Thi-Thanh Van , Truong-Quang Binh , Tran-Nguyen-Trong Phu , Le-Phuong Mai , Truong-Thien Phu , Lam-Quoc Dung , Dang-Vu Thong , Nguyen Minh-Loi , Le-Thuong Vu
Published: March 2024

The aim of this study was to create a dynamic web-based tool to predict the risks of methicillin-resistant Staphylococcus spp. (MRS) infection in patients with pneumonia. We conducted an observational study of patients with pneumonia at Cho Ray Hospital from March 2021 to March 2023. The Bayesian model averaging method and stepwise selection were applied to identify different sets of independent predictors. The final model was internally validated using the bootstrap method. We used receiver operator characteristic (ROC) curve, calibration, and decision curve analyses to assess the nomogram model’s predictive performance. Based on the American Thoracic Society, British Thoracic Society recommendations, and our data, we developed a model with significant risk factors, including tracheostomies or endotracheal tubes, skin infections, pleural effusions, and pneumatoceles, and used 0.3 as the optimal cut-off point. ROC curve analysis indicated an area under the curve of 0.7 (0.63–0.77) in the dataset and 0.71 (0.64–0.78) in 1000 bootstrap samples, with sensitivities of 92.39% and 91.11%, respectively. Calibration analysis demonstrated good agreement between the observed and predicted probability curves. When the threshold is above 0.3, we recommend empiric antibiotic therapy for MRS. The web-based dynamic interface also makes our model easier to use.
Calcinosis in Rheumatic Disease Is Still an Unmet Need: A Retrospective Single-Center Study
Authors: Nita Cristina , Groseanu Laura , Opris Daniela , Predeteanu Denisa , Bojinca Violeta , Berghea Florian , Vlad Violeta , Abobului Mihai , Constantinescu Cosmin , Negru Magdalena , Saulescu Ioana , Daia Sanziana , Mazilu Diana , Borangiu Andreea , Cobilinschi Claudia , Mardale Denisse , Rosu Madalina , Balanescu Andra
Published: March 2024

Patients with immune-mediated rheumatic disease-related calcinosis comprise a subgroup at risk of encountering a more severe clinical outcome. Early assessment is pivotal for preventing overall disease progression, as calcinosis is commonly overlooked until several years into the disease and is considered as a ‘non-lethal’ manifestation. This single-center retrospective study explored the prevalence, clinical associations, and impact on survival of subcutaneous calcinosis in 86 patients with immune-mediated rheumatic diseases (IMRD). Calcinosis predominantly appeared in individuals with longstanding disease, particularly systemic sclerosis (SSc), constituting 74% of cases. Smaller calcinosis lesions (≤1 cm) were associated with interstitial lung disease, musculoskeletal involvement, and digital ulcerations, while larger lesions (≥4 cm) were associated with malignancy, severe peripheral artery disease, and systemic arterial hypertension. The SSc calcinosis subgroup exhibited a higher mean adjusted European Scleroderma Study Group Activity Index score than those without. However, survival rates did not significantly differ between the two groups. Diltiazem was the most commonly used treatment, and while bisphosphonates reduced complications related to calcinosis, complete resolution was not achieved. The findings underscore current limitations in diagnosing, monitoring, and treating calcinosis, emphasizing the need for further research and improved therapeutic strategies to improve patient care and outcomes.
Thoracic Biometry in Patients with Congenital Diaphragmatic Hernia, a Magnetic Resonance Imaging Study
Authors: Neștianu Erick George , Popescu Septimiu , Alexandru Dragoș Ovidiu , Giurcăneanu Laura , Vlădăreanu Radu
Published: March 2024

This is a retrospective study investigating biometric measurements using magnetic resonance imaging (MRI) examinations in congenital diaphragmatic hernia (CDH). CDH is one of the more common causes of pulmonary hypoplasia, with grave consequences for the fetus. Inclusion criteria were patients diagnosed with CDH as the only observed anomaly, who underwent MRI examination after the second-trimester morphology ultrasound. The patients came from three university hospitals in Bucharest, Romania. In total, 19 patients were included in the study after applying exclusion criteria. Comparing the observed values of the thoracic transverse diameter, the thoracic anterior–posterior diameter, the thoracic circumference, the thoracic area, and the thoracic volume with values from the literature, we observed a predictive alteration of these parameters, with most showing Gaussian distribution. We observed statistical significance for most of our correlations, except between the observed and expected thoracic anterior–posterior diameters and the observed and expected thoracic volume values. This is very helpful when complex studies that can calculate the pulmonary volume cannot be obtained, as in the case of movement artifacts, and allows the clinicians to better assess the severity of the disease. MRI follow-up in CDH cases is a necessity, as it offers the most accurate thoracic biometry.