bluuebunny/crossref_metadata_2025 huggingface dataset:
МАҚТА ЕГУ АЙМАҒЫНДА ТҰРАТЫН ӘЙЕЛДЕРДЕГІ ЖҮКТІЛІК КЕЗІНДЕГІ АСҚЫНУЛАР
Authors: А.Р. Жумадилова , С.Н. Кулбаева , Л.Д. Жолымбекова , И.С. Саркулова , А.Е. Абдухамит
Published: November 2024

Қазіргі уақытта адам ағзасына әсер ететін күшті факторлардың бірі пестицидтер – қоршаған ортаға әдейі енгізілген химиялық заттардың ерекше тобы, олар белгілі бір жағдайларда денсаулықтың бұзылу қаупін арттырады. Қазақстан Республикасы қолайсыз экологиялық жағдайы бар өңір болып табылады, онда патогендік факторлардың бірі ксенобиотиктер, оның ішінде халық денсаулығына қолайсыз әсер ететін пестицидтер болып табылады. Зерттеудің мақсаты – мақта егетін аймақта тұратын жүкті әйелдердегі кездесетін асқынулар жиілігін анықтау. Материалдар мен әдістерi: Қарау және салыстыру үшін жүкті әйелдерден екі бақылау тобын таңдадық. Бірінші бақылау тобына 19 бен 40 жас аралығындағы босанатын 80 әйел кірді. Олар мақта аймағында тұратын 212 жүкті әйелдің арасынан таңдалды. Екінші бақылау топқа 19 бен 41 жас аралығындағы 86 босанушы әйелдер кірді. Бұл жүкті әйелдер 225 жүкті әйелдің арасынан таңдалды. Нәтижелерi: I бақылау тобында жүктілікке байланысты асқынулар 64 (80%) болса , 16 (20%) жүктілік асқынусыз өтті. Зерттеуімізде келесі асқынулар байқалды: Жалпы токсикоз – 32 (50%), оның ішінде ерте токсикоз – 20 (52,6%) және кеш токсикоз – 12 (47, 40%); кольпит – 6(9, 34%), түсік тастау қаупі – 4(6,25%), гестациялық гипертензия – 4 (6,25%),іш қату –3(4,7%), дамымаған жүктілік – 3 (4,7%), амниотикалық сұйықтықтың ерте кетуі – 3 (4,7%), гестациялық пиелонефрит – 3 (4,7%), протеинурия – 2 (3,12%), ісіну – 2 (3,12%) , преэклампсия – 2 (3,12%). Нәрестелердің өлі туулыуы байқалмады. II бақылау тобында 86 әйелдің 35-(40,3%)-ында жүктілікке байланысты асқынулар, 51-інде (59,7%) асқынусыз жүктілік болған. Келесі асқынулар байқалды: токсикоз – 15 (42,85%), оның ішінде ерте токсикоз – 10 (66,66%) және кеш токсикоз 5 (33.34%) , түсік тастау – 7 (20%), кольпит – 6 (17,15%), гестациялық гипертензия – 1 (2,86%), ісіну – 4 (11,43%), протеинурия – 2 (5,71%). Нәрестелердің өлі туулыуы байқалмады. Қорытынды: Пестицидтер қоймалары мен агроөнеркәсіптік ұшу-қону жолақтарының жанында тұратын жүкті әйелдер, босану санына қарамастан, қауіп тобына қосылуы керек. Сонымен қатар, егер тексеру кезінде әйелде клиникалық көріністерді күтпестен хлорорганикалық пестицидтер табылса, алдын-алу шаралары мен емделу жүргізу керек.
ПРОГРЕССИРОВАНИЕ ТУБЕРКУЛЁЗА ПРИ ВОЗНИКНОВЕНИИ НЕЖЕЛАТЕЛЬНЫХ РЕАКЦИЙ НА ПРОТИВОТУБЕРКУЛЁЗНЫЕ ПРЕПАРАТЫ (КЛИНИЧЕСКИЙ СЛУЧАЙ)
Authors: Б.С. Шужеев , Г.А. Маскеева , А.Я. Абубакиров , Г.Б. Умутбаева , О.С. Караев , У.Т. Макулбаева
Published: November 2024

В данной статье представлен клинический случай прогрессирования туберкулёза у пациента с наличием хронического вирусного гепатита С и непереносимостью противотуберкулёзных препаратов. Наличие гепатита С осложняет лечение туберкулёза и требует особого внимания к данному контингенту пациентов. При непереносимости противотуберкулёзных препаратов у пациентов с наличием гепатотоксичности I-II степени, а в данном случае сочетание гепатита С и туберкулёза, нет необходимости отменять противотуберкулёзные препараты на длительное время. Необходимо своевременное назначение препаратов прямого противовирусного действия и назначения лечения по индивидуальной схеме с соблюдением активного мониторинга безопасности лекарственных средств. Данный клинический случай показывает важность того, что отмена специфических препаратов на длительный срок, может спровоцировать прогрессирование туберкулёзного процесса в легких с генерализацией в другие органы и ткани.
Occupational Exposure to Unburnt Tobacco Dust and Thyroid Function: A Case-Control Study
Authors:   Department of Genetics and Toxicology, Bhagwan Mahavir Medical Research Centre, Hyderabad, Telangana, India, Racharla Spandhana , Vanitha Baluka ,   Department of Genetics and Toxicology, Bhagwan Mahavir Medical Research Centre, Hyderabad, Telangana, India, Lakkampelly Lakkampelly Madhuri ,   Department of Genetics and Toxicology, Bhagwan Mahavir Medical Research Centre, Hyderabad, Telangana, India, Sultana Shehnaz ,   Department of Genetics and Toxicology, Bhagwan Mahavir Medical Research Centre, Hyderabad, Telangana, India, Chiliveri Prashanth ,   Department of Genetics and Toxicology, Bhagwan Mahavir Medical Research Centre, Hyderabad, Telangana, India, PP Reddy ,   Department of Genetics and Toxicology, Bhagwan Mahavir Medical Research Centre, Hyderabad, Telangana, India
Published: November 2024

Beedi rolling is one of the most common home-based occupations used to meet daily expenses. The process of making beedis is mainly done by women, especially in rural areas. Due to a lack of awareness regarding safety measures, beedi-rolling women are exposed to toxic components present in unburnt tobacco dust. This exposure leads to many health complications among women beedi-rollers. In this study, we investigated how unburnt tobacco dust disrupts thyroid gland homeostasis by altering levels of thyroid hormone and TSH. We included 421 beedi rolling women (BR) and 426 control subjects (NBR) who were not exposed occupationally to any chemical agents. Levels of thyroid hormones (T3, T4) were analysed using competitive ELISA, and TSH levels were analysed using sandwich ELISA. Serum nicotine metabolites were analysed using LC-MS. We observed a statistically significant increase in the levels of T3, T4, anabasine, nornicotine, and cotinine in BR compared to the NBR group. Additionally, significantly lower TSH levels were observed in the BR group. However, the Correlation between nicotine metabolites, and hormones did not show a significant difference in the BR group. We conclude that prolonged exposure to unburnt tobacco dust must have disrupted thyroid function by altering the thyroid hormone, and TSH levels.
Fine-Tuning a Genetic Algorithm for CAMD: A Screening-Guided Warm Start
Authors: Wang Yifan , Fleitmann Lorenz , Raßpe-Lange Lukas , von der Assen Niklas , Bardow André , Leonhard Kai
Published: November 2024

More sustainable chemical processes require the selection of suitable molecules, which can be supported by computer-aided molecular design (CAMD). CAMD often generates and evaluates molecular structures using genetic algorithms. However, genetic algorithms can suffer from slow convergence, and might yield suboptimal solutions. In response to these challenges, this work presents a method to fine-tune a genetic algorithm for CAMD. The proposed method builds on the COSMO-CAMD framework that utilizes a genetic algorithm for solving optimization-based molecular design problems and COSMO-RS for predicting physical properties of molecules. The key idea of the proposed method is to integrate results from a fast large-scale molecular screening into the molecular design framework, thereby enabling targeted initialization of the genetic algorithm, referred to as warm-start. The proposed method is applied in two case studies to design solvents for extracting gamma-valerolactone and phenol, respectively, from aqueous solutions. Compared to the benchmark method, the warm-started COSMO-CAMD framework reduces computing time by up to 70%, discovers fourfold more top performing candidate molecules, and identifies seven tailored molecular fragments, culminating in the discovery of two novel solvents specifically for the phenol case. The optimal solvent is found in all computational runs. Overall, the warm-started COSMO-CAMD framework significantly improves efficiency, effectiveness, and robustness of molecular design.
Highly Efficient Crystallization Studies through Machine Learning and Automation
Authors: Li Zi , Fu Wenbo , Li Bochen , Yao Jia , Yuan Jiuchuang , Bellucci Michael , Sun Guangxu , Song Zhengtian , Liu Shi , Lang Zhu , Ma Jian , Wen Shuhao , Zeng Qun
Published: November 2024

Crystallization is an important process in a broad range of industries, though studies on this topic remain complicated. Recently, machine learning has been applied to resolve complex issues in chemistry and material science. Here we present a machine learning model integrated into a robotic platform to effectively propose and automatically perform crystallization experiments for organic small molecules. The model was pretrained on around 140000 simulated data generated by a kinetic model, and fine-tuned by over 7000 experimental data obtained on the automated workstation. The improved prediction accuracy and working efficiency of our integrated platform were presented in case studies compared with the traditional approach by humans. A feature contribution analysis demonstrates that this model provides a holistic data-based perspective of promoting and inhibiting influences to crystallization. This work thereby demonstrates the feasibility of applying machine learning techniques to solid-state studies to reduce cost, boost efficiency and deepen understanding.
An amide-to-chloroalkene substitution improves the peptide permeability
Authors: Takeo Sayuri , Iio Chihiro , Sakakibara Ai , Takeda Mio , Yamazaki Yuki , Sato Kohei , Mase Nobuyuki , Watanabe Mizuki , NARUMI Tetsuo
Published: November 2024

This study highlights the novel application of Chloroalkene Dipeptide Isosteres (CADIs) in enhancing peptide membrane permeability. Replacing the peptide bond with CADIs in model dipeptides significantly improved passive permeability. This enhancement is attributed to the increased lipophilicity provided by the CADI substitution, as confirmed by AlogP calculations and HPLC retention times. Molecular dynamics simulations further indicated that CADI substitution reduces water interaction, potentially lowering hydration energy. Our findings demonstrate that CADI incorporation can effectively improve the permeability of peptides, offering a valuable approach for developing bioactive peptidomimetics with enhanced pharmacological properties including permeability and hydrolytic stability.
Core-extended Naphthalene Diimide dyads as light-up probes with targeted cytotoxicity toward tumor cells
Authors: Manet Ilse Gert Julia , Doria Filippo , Pirota Valentina , Freccero Mauro , Salvati Erica , Manoli Francesco , Risoldi Carla , Zizza Pasquale , Biroccio Annamaria , Rizzo Angela
Published: November 2024

In the frame of rational drug design this study introduces a novel approach to enhance the specificity of small molecules in targeting cancer cells. The approach starts from the use of dyads merging into a single entity a naphthalene diimide (NDI) and core-extended NDI (ceNDIs), both known as G-quadruplex (G4) ligands and fluorescent probes. The strategy aims to leverage the unique diagnostic strenghts of the ceNDI moiety featuring red emission by improving binding affinity and target selectivity through inclusion in dyads built with different linkers. A flexible and more rigid linker were used for this scope. The newly developed NDI-ceNDI dyads are promising probes as they exhibit both fluorescence turn-on upon DNA recognition and induced circular dichroism signals dependent on DNA conformation. Both dyads are endowed with excellent affinity for hybrid G4 with binding constants two orders of magnitude higher than those for ds DNA. The high cytotoxicity on cancer cell lines further demostrates their potential as therapeutic agents, highlighting the role of the linker in the target selectivity. Specifically, only the dyad with the rigid triazole linker exhibits selectively induces DNA damage in transformed cells, compared to normal cells primarily targeting telomeric regions. Our findings shed light on the DIPAC potential as a promising theranostic agent, offering insights for future development in precision medicine
Electronic spectroscopy and excited state mixing of OThF
Authors: Rodriguez Arianna , Han Jiande , Yan Jiarui , Heaven Michael , Cheng Lan
Published: November 2024

Electronic spectra for OThF have been recorded using fluorescence excitation and two-photon resonantly enhanced ionization techniques. Multiple vibronic bands were observed in the 340 – 460 nm range. Dispersed fluorescence spectra provided ground state vibrational constants and evidence of extensive vibronic state mixing at higher excitation energies. Two-photon ionization measurements established an ionization energy for OThF of 6.283(5) eV. To guide the assignment of the OThF spectra, electronic structure calculations were carried out using relativistic equation-of-motion coupled-cluster singles and doubles methods. These calculations indicated that spin-orbit induced mixing of the 3A" and 4A' states was mediated by a seam of potential energy surface intersections.
Assessing UFF and DFT-tuned Force Fields for Predicting Experimental Isotherms of MOFs
Authors: Cho Yeongsu , Teetz Jakob , Kulik Heather
Published: November 2024

Metal-organic frameworks (MOFs) are promising materials for gas storage and separation applications due to their high tunability and porosity. The rational design of MOFs relies on accurate computational modeling, with grand canonical Monte Carlo (GCMC) simulations frequently employed to model gas uptake. In GCMC simulations, interatomic interactions are typically described using force fields, but no single existing force field can fully capture the diverse chemical environments present in MOFs. Refining force field parameters using density functional theory (DFT) provides a more accurate, ab initio-level description of interatomic interactions. In this study, we evaluate the predictive power of the widely used Universal Force Field (UFF) by comparing its predictions with experimental isotherms for four representative adsorbates, H2, CO2, C2H4, and C2H6, across 379 isotherms from 142 MOFs. The results show that UFF consistently overestimates gas uptake in GCMC simulations. To provide a customized force field for each MOF, we present a practical scheme for fitting force field parameters to DFT-calculated energies for a large set of MOFs. The refined force field successfully reproduces the DFT-calculated interaction energy, effectively correcting UFF’s overestimation of interatomic repulsion. However, because UFF overestimates gas uptake, and the refined force field reduces repulsion further, this refinement amplifies the overestimation. Our analysis suggests that structural defects and atomic motion in MOFs, typically neglected in GCMC simulations, should be addressed to improve agreement of gas adsorption prediction with experiments.
Characterization and integration of a new oxidative flow reactor for use in in vitro and human exposure systems with diesel exhaust and other aerosol
Authors: Choudhary Vikram , Xi Yu , Pham Cynthia , Zhang Yuetong , Hardy Kristen , Rider Christopher F , Zaks Julia , Bertram Allan K. , Chan Arthur , Brune William H. , Carlsten Chris
Published: November 2024

Freshly emitted air pollutants may not represent real-world exposure conditions in human studies, especially for communities exposed to aged air pollutants. This study presents the design and characterization of a new oxidative flow reactor (OFR), named the Fast-oxidation Box (FoxBox, volume of 1019 L). Our aim is to simulate atmospheric aging of diesel exhaust (DE) with this system for cellular (in vitro) and controlled human studies, a unique capability globally. We measured: (a) residence time distribution (RTD) for DE-derived CO2, SO2, and particles, (b) DE particle transmission efficiency, (c) low-volatility organic compounds (LVOC) losses, and (d) particle size distribution, secondary organic aerosol (SOA) formation, and aerosol mass spectra of DE during photochemical oxidation (from OH exposure of (1.9 to 9.5)×1011 molec cm-3 s). Our results demonstrate turbulent flow-like conditions in FoxBox with narrower RTD for particles than gases. The particle transmission efficiency was nearly 100% for mobility diameters between 15 and 615 nm. LVOC losses to FoxBox walls were minimal. The changes in particle size distributions (e.g., formation of ultrafine particles) and chemical composition (e.g., SOA formation, increased O:C, etc.) during photochemical oxidation in FoxBox were like those observed in the atmosphere and other OFRs. Our preliminary study on cell viability found that photochemical oxidation significantly reduced cell viability, supporting observations that communities distant from air pollution sources are affected and vulnerable. The controlled human exposures with more realistic aerosol characteristics, such as those produced by FoxBox, may provide critical insight in this regard that has been lacking to date.
Influence of Pluronic F68 on size stability and acoustic behavior of monodisperse phospholipid-coated microbubbles produced at room temperature
Authors: Wang Yuchen , Spiekhout Sander , Walgode Ana , Collado-Lara Gonzalo , van der Steen Antonius , de Jong Nico , Bosch Johannes , Johnson Benjamin , Kooiman Klazina
Published: November 2024

Ultrasound contrast agents, comprised of phospholipid-coated microbubbles, can be produced as monodisperse populations using a microfluidic flow-focusing device. However, microbubble coalescence remains a significant challenge. High production temperatures (e.g. 55° C) can be used to suppress coalescence, but it complicates the microfluidic device design and is incompatible with targeting agents and drug conjugates. This study investigates the production of monodisperse microbubbles at room temperature with the addition of the amphiphilic surfactant Pluronic F68. Two 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC)-based phospholipid formulations were investigated: F1, containing 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[carbonyl-methoxypolyethylene glycol] (DPPE-PEG5000), and F2, which included both DPPE-PEG5000 and polyoxyethylene(40) stearate (PEG40-stearate). We characterized the size stability and acoustic behavior of monodisperse microbubbles produced with various Pluronic F68 concentrations. Adding 5-10 mol% Pluronic F68 was found to effectively suppress coalescence and facilitated the production of monodisperse microbubbles that remained shelf stability for at least 7 days. Acoustic attenuation measurements revealed a shell stiffness ranging from 0.78 to 0.93 N/m for these microbubbles. The 10 mol% Pluronic F68 addition (10PF) demonstrated superior monodispersity and was selected for further experiments. Upon dilution, the size and resonance frequencies of both F1-10PF and F2-10PF decreased over time, though F2-10PF showed better stability compared to F1-10PF for both metrics. Both F1-10PF and F2-10PF exhibited a stronger subharmonic scattering intensity than SonoVue (clinical approved microbubbles), which offers potential for blood pressure sensing. Our study shows that incorporating Pluronic F68 facilitates the production of monodisperse microbubbles at room temperature that are stable long-term and have excellent acoustical properties, with the F2-10PF formulation demonstrating better stability than the F1-10PF.
Design and Construction of 5-Dof EMG Based Robotic Arm System
Authors:   Assistant Professor, Dept of Medical Electronics,  Sengunthar Engineering College (Autonomous), Tiruchengode, TamilNadu , INDIA, Sathik Muhammadu , V Kanimozhi ,   PG Scholar, Dept of Medical Electronics, Sengunthar Engineering College (Autonomous), Tiruchengode, TamilNadu, INDIA, S Samipriya ,   PG Scholar, Dept of Medical Electronics, Sengunthar Engineering College (Autonomous), Tiruchengode, TamilNadu, INDIA, M Sarumathi ,   PG Scholar, Dept of Medical Electronics,  Sengunthar Engineering College (Autonomous), Tiruchengode, TamilNadu, INDIA
Published: November 2024

Electromyography (EMG) is an alternate method of obtaining muscle signal outputs. As a result, the current development in designing my electric plans has piqued the attention of researchers in this subject. This is because Standard controllers lack essential components, limiting the use of limbs to operate equipment, namely an arm controlled by robotics. EMG signals are subject to noise, including crosstalk, motion artifacts, ambient noise, and intrinsic noise. Electromyography preparation requires careful selection of muscle groups, electrode placement, and environment quality, all of which impact the signal output. The goal of this study is to create an EMG-based robotic arm control system that can be used to help the elderly, individuals with impairments, and those who operate in dangerous places. Initially, a literature review on current human-robot interaction approaches and analysis of the kinematics of a 5 DOF robotic arm has been conducted. Then, utilizing Electromyogram (EMG) data obtained from the muscles of the elbow, away for controlling a 5 DOF robotic arm is provided. Two accelerometers are utilized to record the human arm's gesture and posture, this information is then communicated to the robotic arm as an input. In the experiments, wrist rotation, left, right, up, and down movements were used to establish controlled motion of a 5 DOF robotic arm. The project's goal has been met with the successful development of an EMG-controlled robotic arm. The robotic arm may yet be improved by including Implementing a wireless sensor network with multiple channels.
A Review of Foot pressure Measurement of Diabetic and Analysis Patients
Authors:   Assistant Professor, Dept of Medical Electronics, Sengunthar Engineering College (Autonomous), Tiruchengode, Tamil Nadu, INDIA, Sathik Muhammadu , R Shanmugapriya ,   PG Scholar, Dept of Medical Electronics, Sengunthar Engineering College (Autonomous), Tiruchengode, Tamil Nadu, INDIA, R Sabarinathan ,   PG Scholar, Dept of Medical Electronics, Sengunthar Engineering College (Autonomous), Tiruchengode, Tamil Nadu, INDIA, M Moulika ,   PG Scholar, Dept of Medical Electronics,  Sengunthar Engineering College (Autonomous), Tiruchengode, Tamil Nadu, INDIA
Published: November 2024

Peripheral neuropathy, the main risk factor for diabetic foot ulcers (DFU), causes loss of protective feeling and is linked to very high plantar pressures. The goal of DFU preventive techniques is to lower these elevated plantar pressures. However, there are a number of limitations to the evidence that supports the connection between plantar pressure and DFUs, which could account for the poor prediction accuracy found in prospective studies. Most research measures the vertical, as opposed to the shear, barefoot plantar pressure in lab settings as opposed to in real-world activities. Previous DFU location-specific pressure was not well studied. Prior research has mostly concentrated on walking; however activity tracking studies indicate that more time is spent on other weight-bearing tasks, when a longer duration of lower "peak" plantar pressure may be applied. This suggests that a measure of the cumulative pressure applied over time might be more pertinent than peak pressure, however more investigation is required. Further research is needed, however studies have shown that delivering pressure feedback may lessen plantar pressures. This is an emerging potential use of smart technology. To increase our knowledge of the pressures that lead to DFUs and the efficacy of therapies, more pressure assessments pertaining to location-specific pressures pertaining to all weight-bearing activities are needed.
Equity of access to pathological diagnosis and bronchoscopy for lung cancer in Aotearoa New Zealand
Authors: Gurney Jason , Davies Anna , Stanley James , Whitehead Jesse , Cameron Laird , Costello Shaun , Dawkins Paul , Koea Jonathan
Published: November 2024

background: Māori are less likely to survive their lung cancer once diagnosed, but it remains unclear whether this is partially driven by poorer access to best-practice diagnostic services. methods: We examined all lung cancer registrations in Aotearoa New Zealand between 2007–2019 (n=27,869) linked to national administrative health datasets and further stratified by ethnicity, tumour type and stage of disease. Using descriptive and regression analyses, we compared ethnic groups in terms of the basis of diagnosis (e.g., histology, cytology), receipt of bronchoscopy and travel distance and time to access bronchoscopy. results: We found no differences in access to a pathological diagnosis between ethnic groups regardless of cancer type or stage. We found that Māori within the cohort were marginally more likely to access bronchoscopy than the majority European group; however, we also found that Māori had a lower odds of living close to the location of their bronchoscopy, and a correspondingly higher odds of living 100–200km (adjusted odds ratio [adj. OR] 1.46, 95% confidence interval [CI] 1.26–1.69) or more than 200km away (1.36, 95% CI 1.15–1.61) than Europeans. conclusion: Interventions that aim to further support Māori to overcome the systematic and cumulative disadvantages in access to cancer care should be broadly supported and resourced.
The incidence of atrial fibrillation and its impact on the length of stay following valvular heart surgery
Authors: Fu Yeu-Shiuan , Doughty Lesley , Parke Rachael
Published: November 2024

aim: There is minimal evidence regarding predictors, preventative measures and treatments of new onset of post-operative atrial fibrillation (POAF) in patients undergoing valvular heart surgery. This study aimed to determine the incidence of new onset atrial fibrillation (AF) and its impact on outcomes and length of stay (LOS) for patients following valvular heart surgery. methods: A single-centre, retrospective study was conducted. results: New onset AF was observed in 51/120 (42.5%) patients. Baseline and surgical characteristics were similar between patients who did and did not develop AF, although suggestive older age may increase the risk of developing POAF (p=0.06). New onset AF was significantly associated with longer intensive care unit (ICU) LOS—median increase of 2 days (p=0.002) —and overall hospital LOS—median increase of 1.5 days (p=0.006). Patients who received double valve surgery spent 2.5 times longer in the ICU compared to patients who had an aortic valve replacement (AVR) (p=0.033). conclusion: The incidence of new onset AF following valvular heart surgery was high, with associated prolonged ICU and hospital LOS. Patients undergoing double valve surgery were more likely to have a longer ICU LOS compared with those who received an AVR.
Exploring the Role of Cuprotosis-Associated Genes in Cancer Progression and Therapy Resistance: A Comprehensive Analysis across Multiple Cancer Types
Authors: Hameed Yasir
Published: November 2024

This review presents a comprehensive overview of the role of cuprotosis-associated genes in various cancer types, highlighting their significance in tumor progression and therapy resistance. In breast cancer and colorectal cancer (CRC), dysregulation of genes involved in mitochondrial function and copper metabolism, such as FDX1, LIAS, LIPT1, DLD, DLAT, and PDHA1/PDHB, promotes metabolic reprogramming and enhances cancer cell survival. Ovarian cancer exhibits unique dysregulations in genes like ATP7B, CCS, and COMMD1, influencing copper metabolism and redox signaling pathways, thereby contributing to chemoresistance and tumor growth. Head and neck cancer involves upregulation of MT1X, ATP7A, and CCS, potentially aiding cancer cell survival under oxidative stress conditions. Lung cancer is characterized by distinct dysregulation of genes like SLC31A1, ATOX1, and COMMD1, modulating copper homeostasis and redox signaling to support tumor proliferation. Liver cancer and kidney cancer each present unique sets of dysregulated cuprotosis-associated genes, such as SLC39A4, SCO2, and ATP7A, suggesting novel therapeutic targets specific to these cancer types. Pathway analysis reveals enrichment in mineral absorption pathways, emphasizing the importance of these genes in maintaining cellular mineral homeostasis. Understanding the intricate interplay between cuprotosis-associated genes and cancer biology offers insights into potential therapeutic strategies targeting copper metabolism for improved treatment outcomes across various cancer types.
Effectiveness and Safety of Low-flow Sevoflurane Combined with Remifentanil on Anaesthesia of Patients Undergoing Gynaecological Laparoscopic Surgery
Authors: Sun Liping
Published: November 2024

Objective: To evaluate the advantages of sevoflurane (low-flow) + remifentanil for patients undergoing gynaecological laparoscopic surgery. Methods: 300 patients admitted for gynaecological laparoscopic surgery between July 2020 and July 2023 were selected and divided equally by random number table, 150 cases were counted in the observation group, and sevoflurane (low-flow) + remifentanil was chosen for maintenance anaesthesia; 150 cases were counted in the reference group, and anaesthesia was maintained only with remifentanil. The anaesthesia indexes, haemodynamics, stress reaction indexes, and adverse reaction rate of the two groups were compared. Results: The anaesthesia indexes of the observation group were better than those of the reference group (P < 0.05). Before 5 min of anaesthesia (T1), there was no difference between the haemodynamics and stress reaction indexes of the two groups (P > 0.05). After 30 min of pneumoperitoneum (T2) and immediately after the end of surgery (T3), the hemodynamic and stress indicators of the observation group were lower than those of the reference group (P < 0.05). The adverse reaction rate of the observation group was lower than that of the reference group (P < 0.05). Conclusion: Sevoflurane (low-flow) + remifentanil can improve the anaesthesia indexes of gynecological laparoscopic surgery patients, stabilize intraoperative haemodynamics, reduce the stress reaction, and the safety of medication is high.
Correlation Analysis of Limb Length Differences and Surgical Approaches Following Unilateral Total Hip Arthroplasty
Authors: Shen Yue , Hu Baiqiang , Chen Geng , Wang Guangda
Published: November 2024

Aim: This research aims to analyze the transition from the posterolateral approach (PLA) to the direct anterior approach (DAA) in 101 cases of unilateral total hip arthroplasty (THA). In addition, the study specifically aims to evaluate limb length discrepancy (LLD). Methods: We conducted a retrospective analysis of 101 patients who had unilateral THA from September 2021 to August 2024. The causes of THA included femoral neck fracture (n = 28), osteoarthritis (n = 23), osteonecrosis of the femoral head (n = 25), and developmental dysplasia of the hip (n = 25). The mean age was 61.50 years in the PLA group and 63.00 years in the DAA group. Safety feasibility was assessed by analyzing procedure time, incision length, and bleeding volume. LLD was indirectly evaluated by measuring the difference in central edge angles of the postoperative pelvic orthotopic plate. This was done to assess the superiority of the DAA. Results: The DAA group had a longer operation time, less blood loss, and a shorter incision length compared to the PLA group, with a statistically significant difference (P < 0.05). Additionally, body mass index was found to be linearly correlated with operation length. The LLD in the DAA group was significantly smaller than that in the PLA group (P < 0.05). Moreover, this LLD was linearly associated with the difference in the central edge angle. Conclusion: DAA may effectively control LLD after THA, resulting in less blood loss and shorter incisions, though it may require longer operative time.
Cultivation of Postgraduate Abilities from the Perspective of Enterprise Needs
Authors: Sun Minna , Qin Lei , Xue Yuanfei
Published: November 2024

When cultivating the comprehensive abilities of postgraduates in universities, to prevent disconnection from the market and ensure the effectiveness of talent output, it is necessary to innovate and reform the methods of postgraduate ability cultivation from the perspective of enterprise talent demand. This study first clarifies the research approach, followed by a detailed examination of specific strategies for cultivating postgraduate abilities. It is hoped that the research findings can provide valuable insights for relevant stakeholders, highlighting the significance and value of the study.
Research on Methods for Integrating Craftsmanship Spirit into Vocational Education
Authors: Yang Aiai
Published: November 2024

This paper explores effective methods to integrate the concept of craftsmanship spirit into vocational education. By analyzing the principles of craftsmanship—such as dedication, precision, and innovation—this research highlights the importance of fostering these values among vocational students. Drawing on both theoretical frameworks and practical examples, the paper proposes several strategies for embedding craftsmanship values into the curriculum, including the enhancement of practical training, mentoring programs, and industry partnerships. The integration of craftsmanship spirit is crucial for the professional growth of students and the development of high-quality, skilled labor forces in today’s economy.
Construction of Disaster-aware Communities through Local Wisdom and Social Media
Authors: Mulyono Joko , Paramitha Nurina Adi , Arifiyanti Jati , Suhartini Elly , Ladiqi Suyatno
Published: November 2024

The social construction process runs simultaneously. The utilization of local wisdom and social media is the result of the community construction process. Disaster-aware communities can utilize local wisdom and social media to overcome flood disasters. This research aims to analyze the construction of a disaster-aware community in Wonoasri Village, including the use of local wisdom and social media to overcome disasters. This research uses the construction theory of Berger and Luckmann. The research method used was a qualitative method with a phenomenological approach. Purpose sampling techniques were used to collect research informants. Data collection through observation, interviews, FGD, and documentation. The validity of the data using triangulation and data analysis using interactive models. The research results show that the social construction process runs simultaneously. The social construction process of the community starts from community experience, which shapes community knowledge about floods, the formation of Destana, and the transfer of knowledge, to the utilization of local wisdom and social media to overcome floods in Wonoasri Village.
Social Critique and Cancel Culture: Analyzing Online Comments on Gisella Anastasia's Video with Foucault's Approach
Authors: Wulandari Nur Laily Wulandari , Kusumo Habsari Sri
Published: November 2024

This research analyzes the phenomena of social criticism and cancel culture in the context of the Gisella Anastasia sex scandal, focusing on analyzing netizen comments on YouTube news channels. Foucault's discourse analysis is used to explore how comments reflect power dynamics on social media. These comments fall into four categories: social media shaming, slut-shaming, redemption support, and superficial praise.The research findings show mixed reactions from netizens about the Gisella Anastasia scandal, with social media backlash and slut shaming highlighting strong criticism of her behavior.On the other hand, redemption support illustrates support and forgiveness towards the celebrity's efforts to amend their actions following clarification or apologies. Shallow praise focuses on compliments that are not related to the main issue.The research reveals that social media shaming and slut shaming are the primary comment categories. Using a Foucauldian approach, it examines how these comments reflect systems of discipline and punishment, highlighting the complexities of cancel culture and its impact on interpretation and judgment in the social media age.. The analysis of netizen comments provides insights into how power and social control are manifested in online interactions and their implications on the reputation and public perception of celebrities.
Exploring Preschool Teachers’ Obstacles in Helping Children Teaching Malay Reading Skills
Authors: Syazreena Md Bashah , Suziyani Mohamed , Syawal Amran Mohammad
Published: November 2024

Reading problems among preschool children are not a new thing for preschool teachers. This article discusses the constraints and difficulties when helping preschool children master reading skills. This study used a qualitative method design involving 12 preschool teachers who teach in 12 National Schools in 7 states in Malaysia. The criteria of the non-random sampling selection were based on employment in the preschool field, having eight years of teaching experience, and being a Principal Trainer (JU) in the preschool field. Analysis by the interview method was conducted online. Each interview conducted was recorded. The NVivo software has been used to facilitate the data management and analysis. The research design used Grounded Theory to obtain the findings. The results of this study show that there are 11 factors representing the constraints and difficulties related to helping preschool children master reading skills. Among them are different levels of mastery, being forgetful or having a poor memory, being unable to recognise the alphabet, getting lost or lacking focus, diverse mastery, a lack of family support, limited time, background differences, a lack of interest in reading, the differentiation of the methods used or applied, and also the attitude or maturity of the preschool children. Preschool teachers also use various methods that can stimulate the children's interest and increase their confidence by having fun lessons to help them focus during the reading process, whether in the classroom or at home. This is because the practice of reading is not only focused on school but also elsewhere. In conclusion, the teacher's presentation plays an important role and effective methods need to be taken into account in order to attract children's interest to be involve in the learning session and subsequently increasing the level of mastery in reading. The importance of mastery of reading skills among children is emphasised in relation to their age. This is because reading is an important activity in human life, and because it is a basic skill of self-development related to gaining knowledge.
Digital Leadership and Professional Commitment to Enhance Teacher Innovativeness as a Priority Strategy
Authors: Hidayat Rais , Patras Yuyun Elizabeth , Mulyawati Yuli
Published: November 2024

This research aimed to determine priority strategies for increasing teacher innovativeness in the digital era from digital leadership and professional commitment perspectives. The research employed a mixed methods research approach with four stages: theme exploration, model design, data collection, and analysis/product creation. The study population was teachers in Indonesia, and the sample comprised 623 teachers. The study results show that the priority strategy to increase the innovativeness of teachers is divided into two perspectives: digital leadership and professional commitment. Priority strategies from a digital leadership perspective are as follows: digital competitive and intelligent capabilities, digital communication skills, strengthening digital resilience, the ability of educational innovativeness, and monitoring school performance digitally. Priority strategies from a professional commitment perspective are as follows: involvement in the decision-making process, abilities in evaluation and reflection, improving self-competence, ability to prepare to overcome educational challenges, and teacher discipline in their duties. The results imply that academic institutions need to strengthen digital leadership and professional commitment to promote the innovativeness of teachers in the digital era.
Exploring Challenges Influencing the Discontinued Utilisation of the Flipped Classroom Pedagogy: A Case of South Africa Underprivileged High School and Organic Chemistry
Authors: Chakawodza Josphine Munyaradzi , Mushayikwa Emmanuel , Stephen Magdeline
Published: November 2024

The COVID-19 pandemic accelerated technological advancements in education. However, when the threat of COVID-19 subsided some schools discontinued the use of technology-enhanced flipped classroom. This study reports on challenges that could have influenced the discontinued utilisation of technology-mediated flipped classroom model that supported some of the underprivileged high schools of South Africa during the COVID-19 era. While acknowledging that the final decision on whether to discontinue rests with the teachers, learner challenges are equally important as they can contribute to the teachers’ decisions. Hence, this study, anchored by the TPACK framework and Maslow’s hierarchy of needs theory, explored both learner and teacher challenges that influence discontinuation of the use of the flipped learning model. This entailed using semi-structured interviews of purposively selected teachers and learners (N=8) to close this gap in the literature on the use of flipped classroom in the post-COVID-19 era focusing on organic chemistry. Using deductive thematic analysis, the key challenges that could have contributed to the discontinuation of the use of this teaching model were identified as lack of access to Internet services, stable Wi-Fi and ability to navigate the online learning system, competence, motivation, effect of lack of support from the educational institutions and teacher overloading. These findings contribute to the literature on the continued use of this teaching model beyond emergencies such as COVID-19 by highlighting challenges that educational practitioners should be wary of. Additionally, the study has implications for the need to fast-track infrastructure and teacher professional development in underprivileged high schools.
Teachers’ Perceptions towards Practical Instruction Approach in Teaching Mathematics: A case of Selected Teachers in Ugandan Secondary Schools
Authors: Murangira Frank , Uworwabayeho Alphonse , Twagilimana Innocent
Published: November 2024

Globally, there is a need to address learners' academic achievement, which has historically been poor, particularly in underdeveloped countries. Practical instruction (PI) approach has been perceived by many teachers as a better teaching strategy. Students in Ugandan secondary schools have consistently performed poorly in their O'Level national mathematics examinations. This has been attributed to teachers' failure to teach these students with practical approach in some examinable topics, making the subject very abstract to candidates. This qualitative case study analyzed teachers' perceptions of the practical instruction approach to teaching mathematics and its impact on students' academic achievement in mathematics. Sixteen teachers from chosen secondary schools in Kigezi and Ankole regions were interviewed for the study in order to understand more about their opinions on the value and use of practical instruction in the teaching and learning of mathematics. The data gathered were analyzed using thematic analysis. The study showed that teachers regard PI as one of the best teaching methodologies since it incorporates components that help improve students' creativity and critical thinking. The study also indicated that teachers' perceptions of practical instruction approaches for teaching mathematics are diverse and influenced by a variety of circumstances. Creating supportive settings, offering professional development opportunities, and providing access to resources can assist teachers in effectively incorporating practical instruction methodologies into their teaching practice, resulting in improved student learning outcomes in mathematics. It is recommended that teachers should be well prepared before commencing the teaching and learning process, including all PI components.
Impact of Perceived Internationalization of Higher Education on Student Outcomes
Authors: Alcoba Rowena Clemino , La-Ongsri Waewwan
Published: November 2024

Given the multitude of international education options available to students, academic institutions need to understand better how international students perceive their internationalization efforts and how these perceptions influence student outcomes. Employing quantitative and qualitative methods, this study investigated how student satisfaction and performance are impacted by perceived internationalization. Primary data were collected from 124 international students enrolled in a state university in Thailand using a pre-tested questionnaire. The data were assessed for validity and reliability through exploratory and confirmatory factor analyses. Bottom of Form The predicted relationships were examined using path analysis and mediation analysis. Results indicated neutrality in students' perceptions of their international educational environment and experience. Perceived internationalization was directly related to satisfaction. However, the path modeling analysis showed a negative mediating effect of satisfaction on the relationship between perceived internationalization and performance. This finding suggests that international students may still perform well academically even in non-satisfying educational contexts. The implications for higher education institutions present opportunities to align policies, strategies, and actions toward developing a truly international learning environment that will be beneficial for students.
Shedding Light on The Factors Revealing Students’ Learning Mood of English Language Learning in an Indonesian EFL Classroom
Authors: Muhayyang Maemuna , Munir Munir , Sunra La , Sakkir Geminastiti
Published: November 2024

This study explores the students’ learning mood in learning English as a Foreign Language in higher education covering their enthusiasm, enjoyment, optimism, and sincerity. It employs a descriptive study using a purposive sampling technique and takes 34 respondents from EFL university students. The data were collected through questionnaires, interviews and classroom observation. The result of the study shows the students’ learning mood. It falls into several categories, enthusiasm, optimism, sincerity and enjoyment. It also reveals that the students will improve their learning progress as the lecturer gives both oral and written feedback. This research is expected to be beneficial for lecturers, students and stakeholders to enrich knowledge and develop language skills and proficiency based on learning mood in Indonesian EFL classrooms.
Impact Assessment of Mulat Sa Aklat Reading Program for Sustainability and Continuous Quality Improvement
Authors: Aceron Romel M. , Marasigan Nora V. , Dueñas Rageene Vera
Published: November 2024

This research rigorously assessed and evaluated the MULAT SA AKLAT Reading Program, focusing on its impact, effectiveness, sustainability, and potential for continuous quality improvement. Objectives encompass analyzing participant demographics, baseline knowledge, session-wise progress, participant evaluations, and the adaptability of educational approaches. The program fosters inclusive participation, unveiling varied baseline knowledge and expectations. Positive trajectories in participant performance and confidence indicate knowledge dissemination and skill development. Consistently high ratings in participant evaluations and an upward satisfaction trend affirm sustained engagement. A positive correlation between attendance rates and session numbers highlights sustained interest, with educational approaches showcasing adaptability to diverse learning styles. The MULAT SA AKLAT Reading Program emerges as a meticulously crafted initiative with transformative impact, sustained engagement, and effective adaptation to diverse learning needs. The absence of poor ratings underscores its unwavering quality.  Enhance promotional strategies, implement continuous assessments for improvement, and explore innovative educational approaches to diversify sessions. This research offers crucial insights for refining the program, ensuring sustained impact, and guiding future community-based education.