bluuebunny/crossref_metadata_2025 huggingface dataset:
Building a Fortress Against Fake News
Authors: Fahad Nafiz , Goh Kah Ong Michael , Hossen Md. Ismail , Tee Connie , Ali Md. Asraf
Published: September 2023

Given the prevalence of fake news in today’s tech-driven era, an urgent need exists for an automated mechanism to effectively curb its dissemination. This research aims to demonstrate the impacts of fake news through a literature review and establish a reliable system for identifying it using machine (ML) learning classifiers. By combining CNN, RNN, and ANN models, a novel model is proposed to detect fake news with 94.5% accuracy. Prior studies have successfully employed ML algorithms to identify false information by analysing textual and visual features in standard datasets. The comprehensive literature review emphasises the consequences of fake news on individuals, economies, societies, politics, and free expression. The proposed hybrid model, trained on extensive data and evaluated using accuracy, precision and recall measures, outperforms existing models. This study underscores the importance of developing automated systems to counter the spread of fake news and calls for further research in this domain.
Harry S. Wragge AM (1929-2023)
Authors: Gerrand Peter
Published: September 2023

Harry Stewart Wragge (23 November 1929–31 July 2023), Director of the Telecom (later Telstra) Research Laboratories (TRL) in Melbourne from 1985 to 1992, was a leading Australian research engineer. He catalysed the evolution of the public switched telephone network in Australia from its analogue, electromechanical form in the 1950s and 1960s to the digital, computer-controlled circuit-switched network of the 1980s and 1990s. His own research work was famous for his IST (integrated switching and transmission) project, building the first computer-controlled, integrated digital switch in the world to handle commercial telephone traffic (from 1974 to 1978). He also provided major support to telecommunications research at several Australian universities. 
His many contributions were recognized by honours from the Australian Government, Melbourne and Monash universities, the Pearcey Foundation, the Telecommunications Society of Australia and the City of Frankston.
Language Independent Models for COVID-19 Fake News Detection
Authors: Wong W. K. , Juwono Filbert Hilman , Chew Ing Ming , Lease Basil Andy
Published: September 2023

In an era where massive information can be spread easily through social media, fake news detention is increasingly used to prevent widespread misinformation, especially fake news regarding COVID-19. Databases have been built and machine-learning algorithms have been used to identify patterns in news content and filter the false information. A brief overview, ranging from public domain datasets through the deployment of several machine learning models, as well as feature extraction methods, is provided in this paper. As a case study, a mixed language dataset is presented. The dataset consists of tweets of COVID-19 which have been labelled as fake or real news. To perform the detection task, a classification model is implemented using language-independent features. In particular, the features offer numerical inputs that are invariant to the language type; thus, they are suitable for investigation, as many regions in the world have similar linguistic structures. Furthermore, the classification task can be performed by using black box or white box models, each having its own advantages and disadvantages. In this paper, we compare the performance of the two approaches. Simulation results show that the performance difference between black box models and white box models is not significant.
Effects of sodium borohydride on peroxide bleaching of Pinus brutia Ten. and wheat straw pulps
Authors: ÇİÇEKLER Mustafa , TUTUŞ Ahmet
Published: September 2023

The addition of sodium borohydride (NaBH4) to peroxide bleaching has been investigated for its effects on the bleaching yield, mechanical and optical properties of Pinus brutia and wheat straw pulps. The pulps were subjected to four different bleaching conditions by adding charges of NaBH4 at 0%, 0.5%, 1.0%, and 1.5%, while keeping a constant hydrogen peroxide charge of 7%. The use of NaBH4 in the peroxide bleaching processes of the two pulps increased the bleaching yields. The results show that the addition of NaBH4 significantly improved the mechanical properties of the pulps, including tensile and burst indices. The optical properties of the pulps were also improved with the addition of NaBH4. The increase in mechanical and optical properties can be attributed to the reduction of residual hydrogen peroxide and the removal of metal ions, while the decrease in yellowness is due to the removal of metal ions that can cause oxidative degradation of the pulp. The findings of this study suggest that the addition of NaBH4 as an additive in peroxide bleaching is a promising approach to improve the mechanical and optical properties of P. brutia and wheat straw pulps, which can be further explored in future research.
Anadolu endemiği Kazdağı göknarı (Abies nordmanniana (Stev.) subsp. equi-trojani (Aschers. & Sint. ex Boiss) Coode et Cullen): Bildiklerimiz ve araştırma gereksinimleri
Authors: USTA Nurbahar , TAVŞANOĞLU Çağatay
Published: September 2023

Kazdağı göknarı (Abies nordmanniana subsp. equi-trojani) Biga Yarımadası ve Kızılırmak Deltası arasında yayılış gösteren, endemik ve Dünya Doğa Koruma Birliği (IUCN)’ne göre tehlikede (EN) olan asli bir orman ağacıdır. Bu çalışmanın amacı Kazdağı göknarı üzerine yayınlanmış tüm çalışmaları derlemek ve sonucunda tür hakkındaki bilinenleri ve bilinmeyenleri ortaya koymaktır. Bu amaçla türün güncel taksonomik adı ve tüm sinonim adları kullanılarak literatür taranmış, bunlar arasından doğrudan Kazdağı göknarını konu alan yayınlar seçilerek, yapılan çalışmalar incelenen popülasyonlara (Kazdağları, Uludağ, Batı Karadeniz) ve çalışmaların konularına (taksonomi, evrim ve filogeni, genetik, ekoloji ve ekofizyoloji, morfoloji, hastalıkları ve zararlıları, ürün kullanımı ve özellikleri, silvikültür ve amenajman) göre gruplandırılmış ve her grup altındaki çalışmalar kapsamlı olarak açıklanmıştır. Bu kapsamda 181 bilimsel dergi makalesi, 16 sempozyum bildirisi, 10 teknik rapor ve 21 yüksek lisans ya da doktora tezi olmak üzere toplam 228 yayından oluşan bir açık erişimli bir yayın listesi oluşturulmuştur. Sonuçlar, Kazdağı göknarı hakkındaki çalışmaların 2000’li yıllar sonrası arttığını gösterse de, türün geçmişten gelen taksonomik karmaşası ve evrimsel süreci hakkında henüz yeterli bilginin mevcut olmadığını ortaya koymaktadır. Aynı şekilde Kazdağı göknarının morfolojisi ve ekolojisi üzerine de çalışmalar oldukça sınırlı sayıdadır. İklim değişikliğinin artan etkisiyle birlikte hastalık ve zararlıları daha sık çalışılmaya başlanmış; türün işletilmesi ve yönetimi hakkında 2000 öncesi yayınlar bulunsa da güncel çalışmalara rastlanmamıştır. Endemik ve tehlikede olmasına karşın türün korunmasına yönelik çalışmalar ve önerilerin oldukça sınırlı sayıda olması ve tür hakkında yeterli fizyolojik, ekolojik ve genetik verinin bulunmaması, Kazdağı göknarının korunmasına yönelik çalışmaların ilerlemesi için önemli bir engel teşkil etmektedir.
Fungal endophytes in the needles of native and exotic pine species in a planta-tion in Northwestern Türkiye
Authors: ADAY KAYA Ayse Gülden , DOĞMUŞ LEHTİJARVİ Tuğba , LEHTİJARVİ Asko Tapio
Published: September 2023

The endophytic fungi present in needles of Pinus sylvestris, Pinus pinaster, Pinus nigra, Pinus taeda and Pinus radiata were investigated in Kerpe Research Forest, İzmit in 2016. Ten trees of each pine species were sampled systematically. Previous years green needles were sampled from the lower part of the canopy, from two equally spaced positions around the tree. Each needle was surface sterilized and cut into 0.5 cm sections then individually placed onto malt extract agar plates. DNA was ex-tracted from reprensentative seven isolates and amplified using primers ITS1 and ITS4 targeting the nuclear 5.8S rDNA gene and the two ITS regions flanked between 18S and 28S rDNA genes. Amplicons sequenced in both directions using the univer-sal fungal primers ITS1 and ITS4. Isolations from a total of 1000 needles (200 from each pine species) yielded 750 fungal isolates. Pestalotiopsis funerea (Desm.) Steyaert was isolated at the highest frequency followed by Acremonium sp., Cladio-sporum sp. and Cyclaneusma minus.
Karaçam, kızılçam, boylu ardıç ve meşe ormanlarında bitki tür çeşitliliği ve çevresel faktör ilişkileri
Authors: ÜRKMEZ Halil İbrahim , GÜLSOY Serkan
Published: September 2023

Bu çalışmada Dursunbey (Balıkesir) ilçesinde Karaçam, kızılçam, boylu ardıç ve meşe ormanlarında, bitki tür çeşitliliği ile çevresel değişkenler ve bazı meşçere özellikleri ilişkilendirilmiştir. Alternatif indis (Shannon-Wiener, Simpson, Whittaker) ve sayısal dönüşümlerden faydalanılarak alfa, beta ve gama düzeylerinde çeşitlilik hesaplamaları gerçekleştirilmiştir. İkili doğrusal ilişkiler ve modelleme analiz sonuçlarına göre, yörede karaçam, kızılçam ve boylu ardıç türlerinin hâkim olduğu ormanlarda, meşe ormanlarına kıyasla alfa bitki çeşitliliği daha yüksek bulunmuştur. Ayrıca vadi ya da kanyon arazi yüzey formu özelliği bu ormanlardaki alfa tür çeşitliliğine önemli katkı sağlamıştır. Beta çeşitliliğinde kullanılan alternatif ölçekler ilişkilerde önemli farklılığa sebep olmuştur. 20x20m ölçekli dört alt örnek alan verisine göre yapılan hesaplamalarda beta çeşitliliği meşe ormanlarında en yüksek bulunurken, 100x100m boyutlarındaki ana örnek alanlardan elde edilen verilerde bu durumun tersi olarak meşe ormanlarında en düşük, karaçam ormanlarında ise en yüksek beta çeşitliliği hesaplanmıştır. Diğer yandan meşçerelerin kapalılık derecesi beta çeşitliliğinde önemli fark oluşturmuştur. Beta çeşitliliği en yüksek boşluklu kapalı meşçerelerde (%1-10 arası), en düşük ise tam kapalı meşçerelerde (%71-100 arası)’dir. Beta çeşitliliğinde en etkili çevresel değişken ise yükselti olmuştur. İlçe ormanlarında yükseltinin artışı ile değişen iklim koşulları ve jeomorfolojik heterojenlik beta çeşitliliğinin yükselmesine sebep olmuştur. Bu çalışmada gama çeşitlilik düzeyinde ise istatistiksel olarak anlamlı fark oluşturan herhangi bir çevresel değişken belirlenememiştir.
CFD modelling of the microclimate of a cultivated greenhouse: A validation study between experimental and numerical results
Authors: TIGAMPO Soumaïla , KOOLI Sami , SALAH Nizar Ben , FOUDHIL Walid , ERRAIS Reda , JABRALLAH Sadok Ben , SAMBOU Vincent
Published: October 2023

In this work, we present the validation of a numerical model of a greenhouse thermally in-sulated on three sides with a tomato crop. A CFD software (Ansys-Fluent) was used to solve the numerical model. The discrete ordinate model was included to solve the radiative trans-fer equation. The results of the numerical model were compared with the values of air tem-perature observations at different points in the greenhouse. Good agreement was obtained between the simulated and measured values, with coefficients of determination R2 = 0.77, R2 = 0.84, R2 = 0.99, and R2 = 0.89 for the temperatures of the points 10 cm, 80 cm, and 210 cm above the ground and the average temperature in the greenhouse, respectively. A third-order polynomial curve was drawn between the simulated and measured values of relative humidity in the greenhouse. These R2 values are 0.9786 and 0.7165, the simulated and measured relative humidity, respectively. The simulation results showed low velocity values with an average of 0.525 m/s located between 1.5 m and 2 m from the ground.
Political turnover and business decision: A study of Indonesian public companies
Authors: Rahmah Dzakiyyah Saniyyah , Abbas Yulianti
Published: September 2023

Research aims: This study aims to explore whether and to what extent political turnover (a change of local government head) is associated with a firm’s business decisions, such as tax avoidance and corporate investment.Design/Methodology/Approach: Using a sample of companies listed in the Indonesia Stock Exchange from 2012-2021, the authors measured the association between changes in local government leaders and business decisions using panel data regression with Driscoll Kraay’s Standard Error. The authors hand-collected data on changes in local government leaders in 183 Indonesian cities to measure political turnover and merged the data with financial variables collected from the Eikon database.Research findings: This study uncovered that local political turnover in the region of companies' headquarters was negatively associated with tax avoidance decisions. This study also found that local political turnover negatively affected corporate investment decisions during normal/non-crisis periods. Consistent with the Resource Dependence Theory, the results of this study suggest that firms treat relationships with local government as an important resource. Political turnover thus creates uncertainty on the sustainability of the resources, causing firms to adjust their business decisions.Theoretical contribution/Originality: This study provides an understanding of how changes in political conditions in Indonesia change business strategy decisions. Besides, this research area is still under-studied in Indonesia.Research limitation: Since this study focused on the uncertainty caused by political turnover, this study did not measure firms’ political connections.
The role of financial distress and fraudulent financial reporting: A mediation effect testing
Authors: Reskino Reskino , Darma Aditia
Published: September 2023

Research aims: This study examines the determinants of fraudulent financial reporting with financial distress as an intervening agent.Design/Methodology/Approach: The banking companies listed on the Indonesia Stock Exchange (IDX) between 2017 and 2020 comprised the study's population. One hundred-four companies comprised the entire sample, which was chosen using purposive sampling. The approach employed in this study was partial least squares (PLS)-SEM.Research findings: The results of this study found that financial targets and audit quality significantly affected financial distress. Financial distress had a significant effect on fraudulent financial reporting. Financial targets and audit quality had no significant effect on fraudulent financial reporting. Furthermore, audit quality significantly affected fraudulent financial reporting through financial distress. Financial targets did not significantly influence fraudulent financial reporting through financial distress.Theoretical contribution/Originality: This study provides literature on the role of financial conditions and good corporate governance in preventing fraudulent financial reporting in banking companies. This study can be an insight for practitioners and academics in Indonesia and internationally. Apart from that, this study contributes to the literature on the occurrence of fraudulent financial statements mediated by financial distress, which is not widely discussed, specifically in the context of the banking industry in developing countries.Practitioner/Policy implication: The practical implication in this research is the importance for investors and creditors to be more vigilant and pay attention to corporate governance and financial conditions to reduce errors in decisions based on financial reports. In addition, the strength of good corporate governance indicates that the supervision carried out by management will take the information conveyed to stakeholders free from material misstatement so that the implementation of good corporate governance can prevent fraud. Research limitation/Implication: This study exclusively includes companies in the banking sector listed on the Indonesia Stock Exchange (BEI) between 2017 and 2020. Out of 46 companies, only 26 may be used as research objects according to the purposive sampling method.
Study serum anti-Mullerian hormone levels in women undergoing IVF and its association with affecting factors
Authors: Farzipour Shahla , Jalilvand Faranak , Shabani Shojaei Shayan
Published: September 2023

Background: Infertility means inability of pregnancy after one year of natural continuous intercourse, not using any prevention which is one of the most important problems in every human society. The average rate of infertility in different societies is been estimated to be 8-12%. The aim of this study was to determine the level of anti-Mullerian hormone (AMH) in women undergoing IVF and its associations with effective factors.
Methods: This was a cross-sectional study which was done by using library and field methods. A number of 170 women with the diagnosis of infertility referring to the infertility clinic of Alavi hospital in Ardabil city from August 2021 to December 2021 were enrolled randomly in the study and their clinical data including demographic, anthropometric and hormone levels were gathered and then analyzed by using statistical methods in SPSS version 22 software.
Results: The mean age of women were 31.7±4.68 and AMH level were 3.35±2 ng/ml. There was a strong association between age and AMH level (r=0.68, p=0.001). There was not a significant correlation BMI and AMH levels. In women with the complaint of secondary infertility, prevalence of AMH deficiency was significantly lower than other women (p=0.045). There was no difference in AMH levels between regular and irregular monthly menses.
Conclusions: It can be concluded from our study that increase of age is one of the main factors in AMH levels. Also, the deficiency of this hormone can be a cause in secondary infertility.
Pharmacokinetic and pharmacodynamic evaluation of a single dose of new, first in world, high dose aqueous formulation versus conventional oil based preparation of cholecalciferol
Authors: Changani Mohit , Soni Ameet , Chatterjee Arani , Amarsheda Ashish , Mavadhiya Chandrakant
Published: September 2023

Background: Vitamin D deficiency (VDD) is a common condition in India with prevalence in general population varying from 50-94%. VDD has been associated with increased susceptibility to a wide range of viral infections including COVID-19. It is associated with worse outcomes and greater morbidity and mortality in medical as well as surgical ICUs. The objective of the study was to evaluate the pharmacokinetic (PK)/pharmacodynamic (PD) of aqueous cholecalciferol injection in comparison with conventional oil-based injection in VDD healthy adult subjects.
Methods: 24 eligible vitamin D deficient healthy adult males, fulfilling the inclusion/exclusion criteria, were enrolled in the study. Subjects received a single dose of either test (T) [Aqueous cholecalciferol injection 600K IU/2 mL] or reference (R) [Cholecalciferol 600K IU oil-based injection] intramuscularly. Various PK parameters (Cmax, AUC0-t, AUC0-∞ and Tmax) and PD parameters (concentration of cholecalciferol and 25(OH)D) were measured along with safety analysis.
Results: A significantly higher concentration of cholecalciferol and 25(OH)D were observed with test product compared to reference (p<0.01) from 1-hour post-administration till end of the study. A statistically significant difference between test and reference product was observed for the calculated Cmax and Tmax for cholecalciferol and 25(OH)D (p<0.0001). All 12 (100%) subject in test arm achieved the normal level of 25(OH)D by 72 hr post-administration as compared to none in reference arm (p=0.0017). There were no serious adverse events (SAEs) or deaths reported during the study.
Conclusions: This first in world, aqueous formulation of cholecalciferol injection was found to be superior in various PK/PD parameters as compared to conventional oil based injection, which resulted in rapid and sustained rise in serum 25(OH)D levels.
Molecular classification of breast cancer using IHC markers: experience from a tertiary cancer center in south India
Authors: Nawaz P. N. Shoaib , Sebastian Nikhil , T. Raja , A. Ramya , J. Kumanan , Goswami Uddiptya , Vedanta  , Aishwarya
Published: September 2023

Background: Breast cancer is a very heterogeneous disease. Molecular or intrinsic subtypes of breast cancer are based on the gene expression profiling. Doing gene expression profiling in each case is practically difficult. So most of the labs depend on immunohistochemistry to classify breast tumors into various molecular-like subtypes. In this study, we have used immune histochemistry to classify tumors into various subtypes.
Methods: We have retrospectively collected the data of breast cancer patients treated at Apollo Cancer Center, Chennai, in whom ER, PR, HER 2 Neu and Ki 67 were done, and the data was analyzed.
Results: The commonest molecular subtype observed in the present study was Luminal B HER2 positive, constituting 40% of the cases, followed by a HER2 positive (non-luminal) subtype in 20% of cases. The triple negative subtype was the third most frequent, comprising 18% of the cases. The least frequent subtype was Luminal A, seen in only 8% of cases.
Conclusions: There is a higher proportion of luminal B HER2 positive and triple negative subtypes in our study population compared to the other studies in published literature. The proportion of luminal A was lesser in our study compared to the literature.
Prevalence of needle stick injury and its associated factors among nursing staff working at a tertiary care hospital of North India
Authors: Aziz Shazia , Akhter Aisha , Akhter Khurshida , Kachroo Munira , Khan Zahid Ali
Published: September 2023

Background: Needle stick injury is a serious concern for healthcare workers as it poses a major risk for HIV, Hepatitis and other diseases transmission. The study aimed to determine the prevalence of NSI and its associated factors among nursing staff working at SKIMS, a tertiary care hospital of Kashmir, India.
Methods: A descriptive cross-sectional study was conducted among 200 nurses working in different departments of SKIMS. Data regarding socio-demographic, various organizational and behavioral factors that may contribute to NSI, was collected using self-structured questionnaire and analysed using IBM statistical package for social sciences (SPSS), version 23.
Results: The overall prevalence of NSI among nurses of SKIMS was 61% and it was 43.5% in the last 1 year. The nurses working for >40 hrs per week were found more at risk of NSI and it was more prevalent in young nurses with ≤5 years of experience. The nurses working in emergency unit were found more prone to NSI than the other units and recapping was found as the most common practice responsible for NSI. Post exposure to NSI, only 21.5% were found to wash the injury site with soap, water and applied antiseptics and most of them (75%) had not reported NSI to the concerned body.
Conclusions: The magnitude of needlestick injury among nurses was high. Awareness generation regarding occupational health hazards of NSI, protective measures, the importance of reporting of incident and sharp management is the need of hour.
Expect the unexpected: a case report of bacterial meningitis causing Guillain-Barré syndrome in an immunocompetent person
Authors: Chua Joycel Angelique F.
Published: September 2023

This is the case report of a 36-year-old male presenting as acute onset of progressive bilateral lower extremity weakness, initially managed as a case of Guillain-Barré Syndrome (GBS). However, his cerebrospinal fluid tested positive for Neisseria meningitidis Y, Neisseria meningitidis W135, Streptococcus group B antigen, and Streptococcus pneumoniae. The patient was later treated for bacterial meningitis. Most cases of GBS are preceded by an upper respiratory infection or gastroenteritis. There are only a few reported cases of bacterial meningitis occurring coincidentally with GBS, much more in an immunocompetent individual. This is a rare case of such with good patient recovery and outcome.
Gracilis tendon autograft for medial patellofemoral ligament reconstruction in a 47 years old female with recurrent patellar instability: a case report
Authors: Koentjorowibowo Albertus A. , Laksana Komang M.
Published: September 2023

The medial patellofemoral ligament (MPFL) is a static soft tissue structure that important to prevent subluxation and dislocation of the lateral patella. Chronic patellar instability and recurrent dislocation of patella may lead to further cartilage injury, limitation of daily living activities, limit return to sport and also can lead to severe patellofemoral arthritis of the knee. MPFL reconstruction has been suggested as a surgical treatment for chronic patellar instability. There are many techniques exist, the most important rules to avoid surgical failure and complications. Nowadays, there is no literature evidence for the best reconstruction technique. Many kind of graft choices and affordability of the implant are also become the defining factors, which trying to simulate the native function of MPFL precisely.
Complete heart block: an atypical presentation with an atypical diagnosis
Authors: Mishra Vikas , Chatterjee Trisha , M. Chandramouli
Published: September 2023

Congenital heart block is frequently associated with underlying structural congenital heart disease or connective tissue disorders. Neonatal lupus is considered a form of passively acquired autoimmune disease in which maternal autoantibodies, namely, anti-Ro and anti-La, cross the placenta and injure the previously normal fetal heart. Here, a young female, 30 years of age, who presented with atypical cardiac manifestations, was diagnosed with complete heart block. She was evaluated thoroughly for its etiology, including structural, medication, infective, thyroid and autoimmune panel. Antinuclear antibody (ANA) was positive by immunofluorescence method with 1:160 titre and with fine speckled pattern. Anti-SSA/Ro antibody was positive with a titre of 30.20 units. Anti-Smith antibody was also reported to be positive. On further investigations, her mother also had positive ANA by Immunofluorescence method with a titre of 1:80, with anti dsDNA, anti Ro/SSA, anti La/SSB positivity. The patient was thus diagnosed as a case of lupus causing her to present with complete heart block in adulthood. Patient was managed with TPI followed by PPI and was discharged with no complications. Neonatal lupus can cause heart block of varying degrees that may be noted in utero presenting as congenital heart block. SLE presenting as congenital heart block in young adults is a rare finding. This case report reviews an adult female of SLE presenting to the emergency for the first time with atypical cardiac manifestations and diagnosed as a case of congenital heart block with laboratory investigations revealing lupus as the primary etiology.
A case report of eosinophilic enterocolitis
Authors: Chundempetta Daniyah C. H. , Legha R.
Published: September 2023

A 13-year-old boy was admitted with complaints of abdominal pain and loose stools. Abdomen was distended. Laboratory tests on admission revealed neutrophilic leukocytosis and a peripheral smear done showed severe eosinophilia (33%) and leukocytosis. CT abdomen revealed ascites. Ascitic fluid tapping was done and 1.5 L of straw colored ascitic fluid drained. Ascitic fluid study was suggestive of high protein low SAAG ascites. The possibility of eosinophilic enterocolitis was considered. For confirmation endoscopy and sigmoidoscopy were done and a segmental biopsy was taken. Biopsy was suggestive of significant mucosal eosinophilia of duodenum, stomach, rectum, and eosinophilic abscess in the muscularis layer in the duodenum, stomach, and descending colon.
A case of concomitant connective tissue disorder and thrombotic thrombocytopenic purpura in an Indian middle aged female
Authors: Narula Shubhank , Kakar Atul , Gogia Atul , Batra Tanvi
Published: September 2023

Thrombotic thrombocytopenia (TTP) is a rare disease which is rarely present in adults. Adults usually have an acquired version of disease, associated with some underlying autoimmune disease. There has been paucity of literature about reports which shows the coexistence of connective tissue disorder in patients of acquired TTP. This is a case report of a female who presented with vague symptoms of breathlessness, abdominal pain and petechial rashes and was diagnosed as TTP, developed neurological complications but was stabilized by timely management through plasma exchanges and steroids.
Subcutaneous cysticercosis mimicking tenosynovitis: a rare case with radiological revelation
Authors: Soni Jinal R. , Chaturvedi Ved P.
Published: September 2023

Subcutaneous cysticercosis is a rare manifestation of cysticercosis, caused by the larval stage of Taenia solium. It presents as a swelling or a palpable cystic mass. We describe a 43-year-old female who presented with subcutaneous swelling over her right hand, gradually increasing in size over ten days. Initially, tenosynovitis was suspected clinically. However, an ultrasound of the hand revealed a well-defined, cystic lesion with eccentric echogenic foci and peripheral oedema suggestive of cysticercosis. She was treated with oral albendazole, leading to significant improvement. This case report emphasizes the importance of considering parasitic infections as a potential cause of subcutaneous swelling. It also highlights the significance of utilizing diagnostic imaging for definitive diagnosis and timely treatment.
May-Thurner syndrome causing venous thromboembolism in a young female with Sturge weber syndrome and connective tissue disease
Authors: Narula Shubhank , Agarwal Pankaj Kumar , Garg Ambuj
Published: September 2023

May-Thurner syndrome (MTS) is a rare condition characterized by the compression of the left common iliac vein by the overlying right common iliac artery. It is a unique causal reason for development of deep venous thrombosis (DVT) and pulmonary embolism (PE). Young females developing DVT should be examined and investigated with details as triggers can include trauma, pregnancy, autoimmunity. In this case report we report a case of a young female who had Sturge Weber Syndrome, and how a left hip pain was diagnosed as DVT which led to diagnosis of an underlying MTS and autoimmune trigger for her hypercoagulable state.
Role of silica nanoparticles in pathogenesis of Mesoamerican nephropathy
Authors: Addanki Raja Narendra Divakar , Mannava Anjali Srikanth
Published: September 2023

The authors have done an excellent job in shedding light on Mesoamerican nephropathy (MeN), a lesser-known variant of chronic kidney disease that affects agricultural workers in rural areas especially regions with hot climates like Central America, etc. The inclusion of social factors in the pathogenesis and highlighting the risks posed by nephrotoxic drugs and heat stress leading to subclinical rhabdomyolysis and uricosuria are crucial contributions to the understanding of MeN.
Rosalind Franklin: un caso para analizar con enfoque de género
Authors: Camacho-Beltrán Ángela Stella
Published: September 2023

El caso de Rosalind Franklin es un ejemplo del trato al que son sometidas las mujeres por intentar participar y contribuir a la ciencia. Rosalind lo hizo a principios del siglo XX, cuando la ciencia empezaba a institucionalizarse. Aunque Marie Curie ya había recibido dos premios Nobel, el ambiente científico estaba muy marcado por el patriarcado, definido por una supuesta superioridad masculina.Es posible que Rosalind no haya sido consciente de su situación, como muchas de las científicas que la precedieron. En un merecido reconocimiento a una de las mujeres que más ha aportado a la ciencia, el modelo de ADN debería recibir el nombre de modelo de Watson, Crick y Franklin.Gracias a los numerosos movimientos feministas que han actuado desde mediados del siglo XX, las demandas y las políticas progresistas han ido modificando nuestra cultura social, así como cambios en el trato a las mujeres, y, consecuentemente, en la percepción del papel que pueden desempeñar en la ciencia. A pesar de ello, el número de jóvenes mujeres con vocación científica en el siglo XXI todavía es muy bajo. Aquí se presentan algunas consideraciones sobre la necesidad de establecer políticas de ciencia y tecnología con enfoque de género, que garanticen un avance más ágil de la participación de las mujeres en condiciones de igualdad diferencial que permitan valorar su trabajo en concordancia con sus aportes.
LINC00707 promotes multidrug resistance of ovarian cancer cells by targeting the miR-382-5p/LRRK2 axis
Authors: Zhao Min-Wen , Lin Chang-Jie , Qiu Jian-Ping
Published: October 2023

Multidrug resistance severely limits the efficacy of ovarian cancer (OC) treatment. Recent studies have revealed the carcinogenic role of LINC00707 RNA. However, the role of LINC00707 in the development of multidrug resistance in OC has not been clarified. Therefore, the aim of this study was to investigate the relationship between LINC00707 and multidrug resistance in OC, which can facilitate the development of new therapeutic agents for effectively addressing this issue. The RNA expression of LINC00707, miR-382-5p and leucine-rich repeat kinase 2 (LRRK2) in SKOV3 (a human OC cell line) cells was detected by qRT-PCR. The effects of LINC00707 on the proliferation and viability of SKOV3 cells were determined by MTT assay and colony formation assay. The interaction of LINC00707, miR-382-5p, and LRRK2 was bioinformatically predicted and verified with dual-luciferase reporter assay. In addition, the effect of LINC00707 on drug resistance in SKOV3 cells through targeting the miR-382-5p/LRRK2 axis was explored. The expression of LINC00707 and LRRK2 was significantly increased in SKOV3 cells, while miR-382-5p expression was significantly decreased. The results of bioinformatic prediction and colony formation assay demonstrated that LINC00707 could regulate LRRK2 expression in SKOV3 cells by targeting miR-382-5p. Additionally, knockdown of LINC00707 markedly increased expression of miR-382-5p and decreased that of LRRK2, increased cell proliferation and viability, as well as sensitivity to chemotherapeutic agents in SKOV3 cells. Notably, these manifestations were more obvious with simultaneous knockdown of LINC00707 and miR-382-5p compared with knockdown of LINC00707 alone. LINC00707 is overexpressed in SKOV3 cells and promotes SKOV3 cell proliferation and resistance to chemotherapeutic drugs via targeting the miR-382-5p/LRRK2 axis.
Porcine parasitic zoonosis in the Ashanti region of Ghana
Authors: Amissah-Reynolds Papa Kofi , Kwakye Divine Osei , Yamoah Jennifer Afua Afrifa , Abonie Severin Dzifa , Ofori Samuel Ayetibo , Yeboah Enock Owusu
Published: September 2023

Pigs are coprophagous omnivores that feed on a wide range of food, thus making them susceptible to parasitic infections. This study aimed to examine the prevalence and diversity of gastrointestinal parasitic infections among pigs in the Ashanti Region of Ghana, kept under different management systems. A total of 400 fresh fecal samples from pigs of varying ages and sex were collected and analyzed using standard coproscopical techniques. Questionnaire interviews were used to assess management practices on the pig farms. The associations between age, breed, sex, and management systems and the prevalence of parasites were determined. The overall prevalence of gastrointestinal parasites in pigs was 88.75%, with multiple infections being more common than single infections (p < 0.05). Overall, thirteen (13) genera of protozoa and helminths were recovered from the pigs, including parasites of zoonotic importance to man. Eimeria spp. had the highest prevalence (64.5%), while the least prevalence (0.25%) was recorded for Balantidium coli and Isospora spp. Age, breed, sex, and type of management systems were not significantly associated with infections in pigs. The lack of treatment of pigs creates ideal conditions for the spread of zoonotic infections in the region.
Smartphone use in solid-phase fluorimetric determination of some polypeptide antibiotics in medicinal preparations
Authors:   GENERIUM, Bolshakov Dmitry S. , Shogah Zen Аlabden Chalawi ,   Vladimir State University named after Alexander and Nikolay Stoletovs, Amelin Vasily G. ,   Vladimir State University named after Alexander and Nikolay Stoletovs, The Russian State Center for Animal Feed and Drug Standardization and Quality
Published: October 2023

The analysis of semi-products at different stages of production and finished medicinal products is an integral part of an effective quality assurance system for pharmaceutical production. The traditional methods used in the pharmaceutical field, such as capillary electrophoresis, gas and liquid chromatography, are quite versatile and effective. However, they are distinguished by the high cost of instrumentation and component materials, the need to use high-purity solvents, the lack of mobility and the possibility of in situ studies. Such shortcomings can be overcome by using the digital colorimetry method. Its significant popularization has been facilitated by the development of portable and personal electronic devices, among which the smartphone can be distinguished. The aim of the work was to develop a fast and simple method for the determination of a number of polypeptide antibiotics in drugs by digital colorimetry using a smartphone as a color recording device. To implement the solid phase fluorimetric determination of polypeptide antibiotics, HPTLC plates based on silica gel with an aluminum substrate were used as a matrix. Under these conditions, the fluorescence of actinomycin D, virginiamycin M1, virginiamycin S1, and novobiocin was observed when exposed to monochromatic radiation in the UV part of the spectrum (365 nm). The measurement of fluorescence intensity on the surface of the matrices was carried out using a smartphone. Calibration characteristics were constructed for the determination of polypeptide antibiotics in the concentration range of 32–500 μg/mL. The method for assessing the quality of finished drugs was tested on commercial products “Piostacin”, “Cosmegen”, “Dactinomycin” purchased in retail chains. The relative standard deviation of the analysis results does not exceed 0.05. The duration of the analysis was 10–15 min. Based on the results of the studies, the paper presents a method for determining some antibiotics of the polypeptide series by the intrinsic fluorescence of deposited solutions on a solid substrate during treatment with monochromatic UV radiation. The experimental delivery conditions used allow the analysis of drugs based on actinomycin D, virginiamycin M1, virginiamycin S1, and novobiocin.
Phylogenetic analysis of scorpions of the genus Mesobuthus (Vachon, 1950), inhabiting the territory of Kazakhstan, based on the analysis of fragments of mitochondrial and nuclear genes.
Authors:   Saratov State University, Poverenniy Nikita M. , Anikin Vasily V. ,   Saratov State University
Published: October 2023

The taxonomy of scorpions belonging to the genus Mesobuthus has undergone significant revisions in recent times. Initially, based on the morphological characteristics, scientists identified and described a considerable number of subspecies within different species of this genus. However, in the last decade, modern researchers have “revised” the species diversity of the genus based on the results of genetic and morphological analyses, forming new separate species complexes. As a result, a species complex called “Mesobuthus caucasicus” was identified, which was later reassigned to the genus Olivierus by František Kovařík in 2019. Currently, the genus Olivierus comprises 18 species, with 7 of them inhabiting the territory of Central Asia. The distribution ranges of most Central Asian species of the genus Olivierus overlap with those of the genus Mesobuthus. Specifically, in the territory of the Republic of Kazakhstan, the species Olivierus gorelovi occurs, whose distribution range coincides with that of Mesobuthus thersites. Due to this overlap, the taxonomic status of some scorpion populations inhabiting the territory of the Republic of Kazakhstan remains uncertain and poorly studied. The authors of this study attempted to determine the phylogenetic relationships among individuals from different populations using data obtained from molecular genetic barcoding. The analysis was conducted on three nuclear and one mitochondrial gene fragments of scorpions inhabiting the regions of Zhambyl, Karaganda, Atyrau, Turkestan, Abay, and Almaty. The obtained results indicate that scorpions of the genus Olivierus inhabit the territories of Atyrau, Almaty, Karaganda, and Turkestan regions, while scorpions of the genus Mesobuthus inhabit the territories of Zhambyl, Karaganda, and Abay regions. This study makes a direct contribution to the study of scorpion fauna biodiversity in Central Asia.
Creativity and innovativeness of the subject of labor in the new socio-economic conditions
Authors:   National Research Lobachevsky State University of Nizhny Novgorod, Zakharova Lyudmila N.
Published: October 2023

Introduction. The article analyzes the factors that create a demand for innovative development of the economy: the low level of innovativeness and labor productivity, the growth of bureaucracy in management. The demand of innovative economy for creative personnel is discussed. Theoretical analysis. It is shown that enterprises and organizations do not need so much creative as innovative personnel who may not participate in the creation of something new, but are busy implementing and adopting rapidly developing and fundamentally changing production and managerial technologies. Such personnel can work without distress in the organizational environment with the characteristics of instability, uncertainty, complexity, and ambiguity typical of the VUCA world. The use of theoretical modeling method allowed to develop a typology of personality with a combination of qualities of creativity and innovativeness: conservator, adaptor, creator of ideas and creative innovator, their characteristics are given. The key role of adaptors and creative innovators for enterprises of innovation economy is shown. The author considers the existing limits of personality formation with creative and innovative qualities. Conclusion. The characteristics of organizational culture that contributes to the development of personnel innovativeness were defined. The approaches to the improvement of corporate training, which removes the barriers of innovativeness are proposed.
Difusión transnacional de identidades juveniles en la expansión de las maras centroamericanas
Authors: Martín Álvarez Alberto , Fernández Zubieta Ana , Villarreal Sotelo Karla
Published: October 2023

Las maras Salvatrucha y Barrio 18 son dos pandillas juveniles violentas con amplia presencia en América Central y Estados Unidos. Estos grupos reciben atención creciente por parte de los académicos debido a sus progresivos vínculos transnacionales y los inusitados niveles de violencia que utilizan; este artículo plantea que su expansión a través de las fronteras nacionales se explica en gran medida por su capacidad para generar un atractivo marco de referencia identitario que resuena positivamente en el repertorio culturalde los jóvenes del área centroamericana. La política de deportaciones del gobierno estadounidense, las medidas de “mano dura” implementadas por algunos gobiernos de la región y los movimientos migratorios están facilitando la difusión de esas identidades en el espacio centroamericano a lo largo de la última década.
La comunicación corporal en las elaboraciones identitarias–subjetivas
Authors: Blanco Arboleda Darío
Published: October 2023

El presente artículo revalora la comunicación no verbal y los usos del cuerpo dentro de los estudios sobre las construcciones identitarias. Tiene su énfasis en los jóvenes y los grupos subalternos. Revisa las posturas teóricas de autores preocupados por temas como la identidad, la comunicación y el cuerpo. Estas construcciones teóricas se aterrizan y discuten a la luz del estudio etnográfico sobre los grupos colombias en la ciudad de Monterrey, México.
La cuestión indígena en Argentina: de la efectividad a los contextos de producción
Authors: Alvarez Luciana
Published: October 2023

El presente estudio se realiza a partir de la consideración de que las normas no explican por sí mismas la realidad de lo jurídico. El análisis del proceso de construcción del estatus jurídico del indígena en Argentina apunta al proceso social, histórico y político de producción del sentido de la igualdad y la diferencia jurídicas.Lo que se pretende es elucidar a qué lógicas responden las declaraciones internacionales de derechos y su vigencia relativa y, en cierta medida, qué relación guarda este proceso con aquel otro de instauración y consolidación del Estado liberal en Argentina durante el siglo XIX, durante el cual los pueblos indígenas habrían sido considerados iguales/desiguales de modo selectivo.
Mejorando los programas de combate a la pobreza en México: del ingreso al bienestar
Authors: Rojas Mariano
Published: October 2023

Muchos de los programas sociales y la gran mayoría de los programas contra la pobreza, encuentran su fundamento en el supuesto de que un aumento en el ingreso de las personas se traduce, de manera automática, en un aumento de su bienestar. La presente investigación cuestiona este supuesto con base en la literatura de bienestar subjetivo y en el análisis empírico realizado con información de México. Se muestra que es posible sacar a las personas de la pobreza de ingreso, sin que esto se traduzca necesariamente en un aumento de su bienestar. Se sugieren algunos lineamientos generales para mejorar los programas sociales. Se argumenta que es bueno preocuparse por sacar a las personas de la pobreza de ingreso, pero es aún mejor preocuparse por ubicarlas en una situación que favorezca su satisfacción de vida.AbstractMany social programs, and most poverty–fighting programs, are based on the assumption that increasing income automatically translates into a raise in well–being. This investigation questions this assumption on the basis of the subjective well–being literature and on empirical analyses from Mexico. It is shown that it is possible to get people out of income poverty without necessarily increasing their well–being. The paper enunciates some general principles that can enhance social programs. It is argued that it is fine to be concerned about getting people out of income poverty, but it is even better to be concerned about placing them in a situation that favors their satisfaction with life.
Experimental Study of Heat Transfer in the Interwall Space of a Cryogenic Tank with Powder Insulation
Authors: Klebleev T.I. , Semenov V.Yu.
Published: October 2023

Currently, double-wall cryogenic non-isothermal tanks with vacuum-powder or vacuum-multilayer insulation are used in storage and transportation of such cryogenic liquids as liquid nitrogen, oxygen and liquefied natural gas. If the inner vessel is disrupted, the liquid spills into the heat-insulating space and evaporates as a result of heat inflow from the environment. This increases pressure in the thermal insulation space. To ensure functioning of the tank, it is necessary to limit pressure increase in the heat-insulating space. Results of experiments on evaporation of the liquid nitrogen entering the space filled with powder insulation were presented (expanded perlite was considered in the experiments). Experiments were carried out on a laboratory model simulating the tank heat-insulating space. Nature of the cryogenic liquid distribution in the powder insulation volume was determined, possibility of the cryogenic liquid direct contact with the walls of the tank was shown, and the tank walls temperatures and the cryogenic products evaporation intensity over time were determined. Based on the work results, physical and mathematical model of the emergency process development in the interwall space of a cryogenic tank associated with violation of the inner vessel tightness and subsequent spill of cryogenic liquid into the heat-insulating space was refined