bluuebunny/crossref_metadata_2025 huggingface dataset:
Cervicovaginal lavages uncover growth factors as key biomarkers for early diagnosis and prognosis of endometrial cancer
Authors: Harris Hannah J. , Łaniewski Paweł , Cui Haiyan , Roe Denise J. , Chase Dana M. , Herbst-Kralovetz Melissa M.
Published: November 2024

Endometrial cancer (EC) rates are continuing to rise and it remains the most common gynecologic cancer in the US. Existing diagnostic methods are invasive and can cause pain and anxiety. Hence, there is a need for less invasive diagnostics for early EC detection. The study objective was to evaluate the utility of growth factors collected through minimally invasive cervicovaginal lavage (CVL) sampling as diagnostic and prognostic biomarkers for EC. CVL samples from 192 individuals undergoing hysterectomy for benign or malignant conditions were collected and used to quantify the concentrations of 19 growth and angiogenic factors using multiplex immunoassays. Patients were categorized based on disease groups: benign conditions (n = 108), endometrial hyperplasia (n = 18), and EC (n = 66). EC group was stratified into grade 1/2 endometrial endometrioid cancer (n = 53) and other EC subtypes (n = 13). Statistical associations were assessed using receiver operating characteristics, Spearman correlations and hierarchical clustering. Growth and angiogenic factors: angiopoietin-2, endoglin, fibroblast activation protein (FAP), melanoma inhibitory activity, and vascular endothelial growth factor-A (VEGF-A) were significantly (p < 0.0001) elevated in EC patients. A multivariate model combining 11 proteins with patient age and body mass index exhibited excellent discriminatory potential (area under curve = 0.918) for EC, with a specificity of 90.7% and a sensitivity of 87.8%. Moreover, angiopoietin-2, FAP and VEGF-A significantly (p < 0.05–0.001) associated with tumor grade, size, myometrial invasion, and mismatch repair status. Our results highlight the innovative use of growth and angiogenic factors collected through CVL sampling for the detecting endometrial cancer, showcasing not only their diagnostic potential but also their prognostic value.
Floating ascending aortic thrombus with antiphospholipid syndrome: a case report
Authors: Tajima Shinya , Kudo Tomoaki , Mori Daisuke , Kitabayashi Katsukiyo
Published: November 2024

Background

Ascending aortic thrombus is a rare disease that can cause fatal thromboembolism. The treatment for the disease is not well defined and depends on the clinical experience of surgeons. Most reports of thrombosis in antiphospholipid syndrome (APS) are associated with venous or peripheral arterial thrombosis, and there are almost no reports of thrombosis of the aorta.

Case presentation

A 74-year-old male was referred to our department with claudication of the left leg lasting 3 months. A computed tomography angiography (CTA) and a transthoracic echocardiography demonstrated that a floating and pedunculated mass associated with APS was located at ascending aortic lumen and an embolism in the left superficial femoral artery. Under deep hypothermic circulatory arrest, we resected a floating mass without the graft replacement. CTA 1 year after surgery showed no recurrence of thrombus.

Conclusion

We experienced a rare case of floating ascending aortic thrombi. As in this case, we consider that a floating ascending aortic thrombus with embolic events should be performed by surgical intervention.
Patients Facing Large Language Models in Oncology: A Narrative Review
Authors: Raynaud Charles , Wu David , Levy Jarod , Marengo Matteo , Bibault Jean-Emmanuel
Published: November 2024

The integration of large language models (LLMs) into oncology is transforming patients' journeys through education, diagnosis, treatment monitoring, and follow-up. This review examines the current landscape, potential benefits, and associated ethical and regulatory considerations of the application of LLMs for patients in the oncologic domain.
Stellate Ganglion Block for Electrical Storm Associated With Takotsubo Cardiomyopathy: A Case Report
Authors: Özdemir İrem , Sincer Yasemin , Yaylak Doruk , Aygün Elif , Tülümen Erol , Şentürk Evren
Published: November 2024

Takotsubo cardiomyopathy (TCM) is a reversible condition characterized by apical ballooning of the left ventricle, primarily triggered by catecholamine discharge due to stress. Patients may present with symptoms similar to acute coronary syndrome or with refractory ventricular arrhythmias such as QT prolongation, ventricular tachycardia, and ventricular fibrillation. We report a case of TCM with prolonged QT intervals and refractory ventricular arrhythmias, triggered by noncardiac systemic insult, that responded successfully to stellate ganglion block (SGB). This case highlights the potential of SGB as an effective intervention for managing refractory arrhythmias in TCM patients.
Mutation in Prkra results in cerebellar abnormality and reduced eIF2α phosphorylation in a model of DYT-PRKRA
Authors: Burnett Samuel B. , Culver Allison M. , Simon Tricia A. , Rowson Taylor , Frederick Kenneth , Palmer Kristina , Murray Stephen A. , Davis Shannon W. , Patel Rekha C.
Published: November 2024

Variants in the PRKRA gene, which encodes PACT, cause the early-onset primary dystonia DYT-PRKRA, a movement disorder associated with disruption of coordinated muscle movements. PACT and its murine homolog RAX activate protein kinase R (PKR; also known as EIF2AK2) by a direct interaction in response to cellular stressors to mediate phosphorylation of the α subunit of eukaryotic translation initiation factor 2 (eIF2α). Mice homozygous for a naturally arisen, recessively inherited frameshift mutation, Prkralear-5J, exhibit progressive dystonia. In the present study, we investigated the biochemical and developmental consequences of the Prkralear-5J mutation. Our results indicated that the truncated PACT/RAX protein retains its ability to interact with PKR but inhibits PKR activation. Mice homozygous for the mutation showed abnormalities in cerebellar development as well as a severe lack of dendritic arborization of Purkinje neurons. Additionally, reduced eIF2α phosphorylation was noted in the cerebellum and Purkinje neurons of the homozygous Prkralear-5J mice. These findings indicate that PACT/RAX-mediated regulation of PKR activity and eIF2α phosphorylation plays a role in cerebellar development and contributes to the dystonia phenotype resulting from the Prkralear-5J mutation.
The genome sequence of the long-horned nomad bee, Nomada hirtipes Pérez, 1884
Authors: Falk Steven ,   University of Oxford and Wytham Woods Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: November 2024

We present a genome assembly from an individual female Nomada hirtipes (the long-horned nomad bee; Arthropoda; Insecta; Hymenoptera; Apidae). The genome sequence has a total length of 316.5 megabases. Most of the assembly (90.79%) is scaffolded into 16 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 29.88 kilobases in length. Gene annotation of this assembly on Ensembl identified 11,693 protein-coding genes.
Tora dla narodów świata. Prawa noachickie w ujęciu Majmonidesa
Authors: Majdanik Piotr
Published: November 2024

Tematem książki jest problematyka praw noachickich w pierwszym kodeksie żydowskiego prawa religijnego, Miszne Tora, słynnego halachisty i filozofa Mojżesza Majmonidesa. Prawa te stanowią – według Tory ustnej – nadany przez Boga kodeks etyczny przeznaczony dla całej ludzkości. Zdaniem autora pracy to uniwersalistyczne i mesjanistyczne założenia Miszne Tora skłoniły Majmonidesa do zawarcia w swoim kodeksie – co odróżnia go od innych kodyfikatorów – także regulacji przeznaczonych dla nie-Żydów w czasach, gdy przestrzeganie tych przykazań stanie się kwestią bieżącą. Ustanowienie Tory ustnej głównym nośnikiem tradycji praw noachickich prowadzi do uznania wagi wiary w objawienie jako gwarancji zbawienia dla nie-Żydów oraz do nałożenia szczególnych obowiązków na Żydów jako depozytariuszy tej tradycji. Prawo noachickie jest prawem boskim, a jego cel stanowi nie tylko zapewnienie porządku społecznego, ale także umożliwienie człowiekowi osiągnięcie doskonałości. Chociaż prawo to w ogólnym zarysie jest zbieżne z prawem naturalnym, jednak wszystkie jego aspekty niezbędne do osiągnięcia tej doskonałości są dane tylko przez objawienie. Majmonides opiera się w swoim kodeksie wyłącznie na źródłach rabinicznych, starając się godzić sprzeczne opinie. Ale tym, co go wyróżnia, jest nie tylko jego racjonalizm i uniwersalizm, ale też ewolucjonizm, obecny zarówno w kumulatywnej koncepcji żydowskiej tradycji ustnej oraz praw noachickich i żydowskich, jak i wizji drogi prowadzącej od religii pogańskich do monoteizmu i czasów mesjasza. Ewolucjonizm ten w wymiarze jednostkowym wyraża się w postulacie samodoskonalenia i rozwoju człowieka, dzięki któremu może on przekroczyć granice swojego przyrodzonego świata.
pokaż tył okładki Matka Polka na odległość. Z doświadczeń migracyjnych robotnic 1989-2010
Authors: Urbańska Sylwia
Published: November 2024

W debacie wokół przemian współczesnych rodzin i wzorców płci rzadko dyskutuje się o doświadczeniach kobiet spoza klasy średniej. W istocie niewiele wiemy na temat tego, jak po 1989 roku zmieniały się biografie, tożsamości i role rodzinne rolniczek i robotnic. Tymczasem od co najmniej kilku dekad to właśnie zwalniane z restrukturyzujących się fabryk pracownice, rolniczka i gospodynie domowe są bohaterkami cichej, niewidzialnej, choć masowej ewolucji. Jako (nie)legalne migrantki – sprzątaczki i opiekunki dzieci, osób starszych i chorych – zamieszkujące wraz z milionami podobnych sobie globalnych robotnic getta migracyjne w metropoliach Europy i Ameryki, musiały zmierzyć się z nowymi nierównościami, gruntownie przeorganizować rolę, tożsamości rodzinne i wzorce płci. Jak Polki radziły sobie z wieloletnią przymusową rozłąką z dziećmi w sytuacji, gdy „opieka na odległość” stała w sprzeczności z figurą matki rezydencjalnej utrwaloną w świadomości jako kanoniczna i niemodyfikowalna? Jak zmieniały się przy tym ich relacje z mężami, rodzinami i społecznościami lokalnymi? O jakich doświadczeniach , jakim językiem mówi „matka Polka na odległość”? Jakie kulisy życia polskich rodzin zaczęła odsłaniać, kiedy znalazła się tak – poza granicami domu, tradycyjnego świata społecznego wsi, miasteczka, państwa? Z czym wiąże się „postmodernizacja ubogich”? Autorka odpowiada na te pytania, zastanawiając się jednocześnie, czy od 1989 roku – kiedy okno dla masowych migracji kobiet otworzyło się szerzej – mieliśmy do czynienia z niedostrzeżoną rewolucją płci w społecznościach zwykle szufladkowanych jako twierdze tradycyjności. Analizy powstały na podstawie zebranych przez autorkę narracji autobiograficznych kobiet, których doświadczenie życia między dwoma krajami wpisało się w dwie dekady transformacji 1989-2010. Książka nie mogłaby jednak powstać bez intensywnych badań terenowych, prowadzonych w Polsce I Belgii. Dały one wgląd w życie migrantek, ich rodzin i społeczności na wsiach i w małych polskich miasteczkach, a także w gettach migracyjnych Brukseli.
What Would Love Do Now? Imagining a Good Death … and Living an Appreciative Life
Authors: Barnes Julie
Published: November 2024

Written in lockdown, in response to stories of people dying alone in hospital, the poem What Would Love Do Now? expresses what a good death looks like for me, if there is a choice. When I started sharing this poem about a good death, I never imagined how it would grow and ripple into so many forms and inspire so many conversations and resources. For me, it is an example of the power of Appreciative Inquiry – seeking and learning from peak experiences, imagining what might be and bringing possibilities into existence.
Tendencia Editorial UR Número 37
Authors: Castro Henao Pablo A. , García Bendezú Luis , Díaz Chávez Natalia , Bedoya Bedoya Luz Mirella , Jiménez Durango Víctor , Santofimio Delgado Carolina
Published: November 2024

En este Boletín, hemos decidido invitar a algunas bibliotecas comunitarias reconocidas por promover o impulsar iniciativas de lectura que surjan y se desarrollen desde las propias comunidades. Nuestro objetivo es mostrar ejemplos destacados de bibliotecas comunitarias en sus regiones y, en particular, conocer de primera mano cómo han sido sus experiencias al llevar a cabo estos proyectos. Asimismo, deseamos brindar un espacio a investigadores e instituciones que trabajan en el fortalecimiento de las redes de bibliotecas comunitarias, con el fin de visibilizar este gran esfuerzo por fomentar la lectura en las comunidades.
An Intertemporal Risk Factor Model
Authors: Chabi-Yo Fousseni , Gonçalves Andrei S. , Loudis Johnathan A.
Published: November 2024

Prominent factor models are based on tradable factors that do not represent theoretically relevant risks. To address this issue, we develop a factor model that captures the risks to long-term investors present in the intertemporal capital asset pricing model (ICAPM). Empirically, we construct intertemporal risk factors as long-short portfolios based on stock exposures to dividend yield and realized variance. These tradable factors mimic news to long-term expected returns and volatility, and they offset part of the marginal utility increase in recessions induced by wealth declines. Our intertemporal factor model estimation implies significant risk prices that are consistent with the ICAPM restrictions under moderate risk aversion. Moreover, our model performs well relative to previous factor models in terms of its tangency Sharpe ratio and its pricing of key test assets, including single stocks, industry portfolios, and portfolios sorted on risk exposures and lagged anomalies.

This paper was accepted by Will Cong, finance.

Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2023.00261 .
Instructions and Incentives in Organizations
Authors: Meagher Kieron J. , Prasad Suraj , Wait Andrew
Published: November 2024

We propose a different perspective on organizations, emphasizing the role of instructions in providing incentives. In our framework, there is a conflict of interest between a principal and an agent over the course of action. When preferences are aligned over executing a course, the principal can selectively instruct the agent on a preferred course to steer the agent toward it. Because less able (less confident) agents are more responsive to instructions, hiring these types of agents can be beneficial. This steering role of instructions toward a course of action helps us understand why and when firms are reluctant to hire overqualified (high-ability) workers, how worker risk aversion can be valuable to an organization, why instructions, although more likely to be used, are less intense, in more uncertain environments, and why instruction-giving and incentive pay go hand-in-hand.

This paper was accepted by Joshua Gans, business strategy.
Leadership characteristics to reduce staff attrition and absence related to burnout
Authors: Paterson Scott
Published: November 2024

Burnout among the paramedic profession is an increasing problem and not enough is being done to improve the current climate. It is for this reason that paramedics should individually contribute to the reduction of this issue by developing their own leadership characteristics, such as emotional intelligence, social intelligence, and stress and conflict management. Evidence suggests that these qualities and behaviours reduce the possibility of being subject to burnout symptomology. Implementing positive stress and conflict-management strategies will create a healthcare environment, which will be more enjoyable to work in. Emotional and social intelligence increase the resilience of prehospital clinicians who are subject to occupational challenges on a daily basis. Wider influences such as ambulance trusts, health services and governing bodies have implemented strategies to tackle this issue but clinicians can lead the change from the front line.
Integrating into my ‘green family’
Authors: Workman Ellie
Published: November 2024

In her last Student Column, Ellie Workman reflects back on her journey this past year, as well as looking ahead to her third year and her transition towards becoming an official part of the paramedic community
Highs and lows
Authors: Sofield Katy
Published: November 2024

In her last NQP Perspective column, Katy Sofield reflects on her last 12 months, having picked up her life to start a new one as a paramedic, and the many ups and downs along the way
Advancing healthcare through laboratory on a chip technology: Transforming microorganism identification and diagnostics
Authors: Ardila Carlos M
Published: November 2024

In a recent case report in the World Journal of Clinical Cases , emphasized the crucial role of rapidly and accurately identifying pathogens to optimize patient treatment outcomes. Laboratory-on-a-chip (LOC) technology has emerged as a transformative tool in health care, offering rapid, sensitive, and specific identification of microorganisms. This editorial provides a comprehensive overview of LOC technology, highlighting its principles, advantages, applications, challenges, and future directions. Success studies from the field have demonstrated the practical benefits of LOC devices in clinical diagnostics, epidemiology, and food safety. Comparative studies have underscored the superiority of LOC technology over traditional methods, showcasing improvements in speed, accuracy, and portability. The future integration of LOC with biosensors, artificial intelligence, and data analytics promises further innovation and expansion. This call to action emphasizes the importance of continued research, investment, and adoption to realize the full potential of LOC technology in improving healthcare outcomes worldwide.
Pulp health and calcific healing of a complicated crown–root fracture with additional root fracture in a maxillary incisor: A case report
Authors: Li Na , Ren Yue-Yue , Tang Ying , Yang Qi , Meng Tian-Tian , Li Song , Zhang Jing
Published: November 2024

BACKGROUND

Complicated crown–root fracture (CRF) involves severe injury to the crown, root, and pulp, and may be accompanied by multiple root fractures. The loss of a tooth has lifelong consequences for children and teenagers, but the maintenance of pulp health and the calcific healing of multiple root fractures are rarely reported in the literature.

CASE SUMMARY

This case reports healing of a permanent tooth with complicated crown–root and additional root fractures, in which pulp health was maintained. A 10-year-old girl fell and fractured the root of her maxillary left central incisor at the cervical level. After the coronal fragment was repositioned, the tooth was splinted until the tooth was no longer mobile, 2 years later. Eight years after treatment, the tooth has remained asymptomatic with vital pulp and localized gingival overgrowth. Cone-beam computed tomography revealed not only calcified healing of the CRF but also spontaneous healing in an additional undiagnosed root fracture. The fracture line on the enamel could not be healed by hard tissue and formed a groove in the cervical crown. It was speculated that the groove was related to the localized gingival overgrowth.

CONCLUSION

This case provides a clinical perspective of the treatment of a tooth with a complicated CRF and an additional root fracture.
Challenges and improvement strategies in the hospitalization of chronic multimorbid patients
Authors: Fontalba-Navas Andres , Pozo Muñoz Francisco , Garcia Cisneros Rogelio , Garcia Larrosa Maria Jose , Callejon Gil Maria del Mar , Garcia Delgado Ignacio , Jimenez Martinez Maria Belen
Published: November 2024

BACKGROUND

Addressing the growing challenge of hospitalizing chronic multimorbid patients, this study examines the strain these conditions impose on healthcare systems at a local level, focusing on a pilot program. Chronic diseases and complex patients require comprehensive management strategies to reduce healthcare burdens and improve patient outcomes. If proven effective, this pilot model has the potential to be replicated in other healthcare settings to enhance the management of chronic multimorbid patients.

AIM

To evaluate the effectiveness of the high complexity unit (HCU) in managing chronic multimorbid patients through a multidisciplinary care model and to compare it with standard hospital care.

METHODS

The study employed a descriptive longitudinal approach, analyzing data from the Basic Minimum Data Set (BMDS) to compare hospitalization variables among the HCU, the Internal Medicine Service, and other services at Antequera Hospital throughout 2022. The HCU, designed for patients with complex chronic conditions, integrates a patient-centered model emphasizing multidisciplinary care and continuity post-discharge.

RESULTS

The study employed a descriptive longitudinal approach, analyzing data from the BMDS to compare hospitalization variables among the HCU, the Internal Medicine Service, and other services at Antequera Hospital throughout 2022. The HCU, designed for patients with complex chronic conditions, integrates a patient-centered model emphasizing multidisciplinary care and continuity post-discharge.

CONCLUSION

This study demonstrates the effectiveness of the HCU in managing patients with complex chronic diseases through a multidisciplinary approach. The coordinated care provided by the HCU results in improved patient outcomes, reduced unnecessary hospitalizations, and better management of patient complexity. The superiority of the HCU compared to standard care is evident in key outcomes such as fewer readmissions and higher patient satisfaction, reinforcing its value as a model of care to be replicated.
Wilson's disease in two siblings from Ecuador: Two case reports
Authors: Carrera Enrique , Alvarado Jonathan , Astudillo Martina , Pillajo Galo
Published: November 2024

BACKGROUND

Wilson's disease (WD) is a rare metabolic disorder of copper accumulation in organs such as liver, brain, and cornea. Diagnoses and treatments are challenging in settings, where advanced diagnostic tests are unavailable, copper chelating agents are frequently scarce, healthcare professionals lack disease awareness, and medical follow-ups are limited. Prompt diagnoses and treatments help prevent complications, improve patients’ quality of life, and ensure a normal life expectancy. The clinical presentations and outcomes of WD can vary within a single family.

CASE SUMMARY

We present the cases of two siblings (19 and 27 years) from a consanguineous family in rural Ecuador, diagnosed as having WD during a family screening. The male patient, diagnosed at age 19 after his brother’s death from acute liver failure, presented with compensated cirrhosis, neurological symptoms, and bilateral Kayser-Fleischer rings. He developed progressive neurological deterioration during an irregular treatment with D-penicillamine due to medication shortages. His condition improved upon switching to trientine tetrahydrochloride, and his neurological symptoms improved over an 8-year period of follow-ups. The female patient, diagnosed at age 10, exhibited only biochemical alterations. Her treatment history was similar; however, she remained asymptomatic without disease progression over the same follow-up period. We discuss the potential influence of epigenetic mechanisms and modifier genes on the various phenotypes, emphasizing the need for research in these areas to optimize therapeutic strategies.

CONCLUSION

Our patients’ medical histories show how early diagnosis and treatment can prevent disease progression; and, how suboptimal treatments impact disease outcomes.
Extremal spectral radii of uniform supertrees
Authors: Yu Guanglong , Sun Lin , Pan Lijun , Zhang Hailiang
Published: November 2024

For a hypergraph $\mathcal{G}=(V, E)$ consisting of a nonempty vertex set $V=V(\mathcal{G})$ and an edge set $E=E(\mathcal{G})$, its adjacency matrix $\mathcal {A}_{\mathcal{G}}=[(\mathcal {A}_{\mathcal{G}})_{ij}]$ is defined as $(\mathcal {A}_{\mathcal{G}})_{ij}=\sum_{e\in E_{ij}}\frac{1}{|e| - 1}$, where $E_{ij} = \{e \in E : i, j \in e\}$. The spectral radius of a hypergraph $\mathcal{G}$, denoted by $\rho(\mathcal {G})$, is the maximum modulus among all eigenvalues of $\mathcal {A}_{\mathcal{G}}$. In this paper, we represent some results on the spectral radius changing under some graphic structural perturbations. With these results, among all $k$-uniform ($k\geq 3$) supertrees with fixed number of vertices, the supertrees with the maximum, the second maximum, and the minimum spectral radius are completely determined, respectively.
Design and Synthesis of Disk-liked Benzotrithiophene Small Molecules for the Organic Solar Cells Material
Authors: Wu LI-Chuan , Chen Xin-Yi , Lin Chih-Hung
Published: November 2024

This study explores the design and synthesis of small molecules specifically tailored for organic solar cells, aiming to enhance their solubility, film-forming properties, and thermal stability through strategic material design. By achieving these improvements, we sought to advance the technology of organic solar cells. We successfully designed and synthesized a triangular disc-shaped small molecule material with benzotrithiophene as the core. To accurately determine the structure and properties of the target compound, we employed advanced characterization techniques, including TGA, NMR, and DSC. The results confirmed that the material exhibited high purity, thermal stability, and solubility. These remarkable attributes suggest significant potential for the material's use as an active layer in solar cells, paving the way developing of high-performance organic solar cells and opening new avenues in the field.
Recent Advancement in the Green Synthesis of Bis(indolyl) Methane via One-pot Multicomponent Condensation Strategy – A Mini Review
Authors: Bedi Pooja , Kaur Rajbir , Bose Reshmi , Pakhira Bholanath , Roy Manas , Pramanik Tanay
Published: November 2024

Bis(indolyl)methane’s (BIMs) are highly versatile heterocyclic frameworks that have gained recognition for their wide range of applications in the therapeutic and pharmaceutical sectors, and play an essential role in the drug discovery system. Though several methodological approaches have been adopted for the synthesis of BIMs, these methods have limitations in terms of using hazardous solvents, transition-metal catalysts, and ultimately generating substantial waste. This review emphasized the green synthesis of BIMs, using the one-pot multicomponent condensation (OPMC) method, which offers BIM synthesis via renewable catalysts, green solvents, or a catalyst-free approach. The OPMC method offers numerous advantages, such as reduced time, labour, cost, and waste products. Multicomponent condensation reactions are very effective in synthesizing highly functionalized organic molecules in one step from readily available starting materials. Despite advancements, challenges persist in ensuring the catalyst's stability for optimal yields and compatibility with various substrates. In the present context, only the OPMC synthesis of bis(indolyl) methane was articulated, which provides valuable insights for researchers seeking sustainable pathways for BIM synthesis.
Method Development and Validation of Quetiapine Fumerate by Using RP-HPLC
Authors: Singh Abhinav , Nagarajan K. , Grover Parul , Goel Richa
Published: November 2024

A rapid, precise, and selective reverse-phase high-performance liquid chromatography (RP-HPLC) method was established and validated for the analysis of QTPF (QUETIAPINE FUMERATE) pure drug as well as commercial formulation. This RP-HPLC approach is designed for the regular determination of QTPF in both laboratory-prepared mixtures and combined pharmaceutical formulations. The separation process utilized an INERTSIL C-18 ODS column (physical dimension 250×4.6mm, 5µm particle size), employing a mobile phase of methanol and ammonium acetate (30 Mm) in a 95:5 ratio, with a flow rate of 1ml/min. The detection of QTPF was achieved using UV spectrophotometry method. QTPF was found to be highly soluble in ACN and methanol in ratio of 70:30, and its wavelength was found to be 252nm. Retention time of QTPF was found to be 3.4 min. The LOD and LOQ values were found to be 0.0001 (µg/ml) and 0.0003, (µg/ml) respectively. In the linearity curve of 2 to 64(µg/ml) of sample, correlation coefficient R2 is seen to be 0.9992. The system suitability parameters such as theoretical plates and tailing factor were found to be 1.99 and 1.30, respectively, and RSD was found to be 1.45.
Ca/Al and Ca/Fe as Indicators of Terrigenous and Marine Origin in East Coast Peninsular Malaysia During Holocene
Authors: Sharif Hamad Maalim , Shaari Hasrizal , Minhat Fatin Izzati , Shirajuddin Nik Hani Shahirah Nik , Naim Erick , Akhir Mohd Fadzil , Sheikh Mohammed Ali
Published: November 2024

A coastal area is an area that is very exposed to sea level changes for a long period, especially during the Holocene. Three marine sediment cores (TRC 3 and TER16-GC13C) in the offshore area were analysed for radiocarbon (14C) and some geochemical elements (Na, Al, Ca, Fe, Li, Pb, Zn, and Ba) in response to the terrigenous- and marine-originated sediment changes of in East Coast Peninsula Malaysia (ECPM) during the Holocene epoch. Across three Holocene stages, geochemical elements show a distinct temporal pattern. The average concentrations of the studied metals were in decreasing order as follows: Al > Na > Ca > Fe > Pb > Zn > Li > Ba. Dominant terrigenous/marine origin was captured by the ratio Ca/Al and Ca/Fe in the early Holocene/late Holocene. The present study suggests that sea level transgression is the primary factor controlling the shifting of terrigenous- and marine-originated sediments in the ECPM.
Assessing the Protective Effects of PC-1 Formulation on Ethanol-Induced Gastric Ulcer Model in Wistar Rats: A Comprehensive Study
Authors: Choudhary Vijul Kumar , Mishra Shardendu Kumar , Kapoor Garima , Chaudhary Shubham , Ghai Roma , Singh Balwan , Kaurav Monika
Published: November 2024

The PC-1 formulation, renowned for its diverse biological properties, has yet to be thoroughly examined for its effects on stomach ulceration. Acute toxicity assessment of a lower dose (1000 mg/kg) of PC-1 formulation did not exhibit any observable signs of toxicity, suggesting its potential as protective mediator in contrast to stomach epithelial mutilation. The omeprazole group received 30 mg/kg omeprazole orally. The investigational groups were orally gavage with PC-1 extract formulation at dosage 50mg/kg, 100mg/kg, and 200mg/kg in (1%) CMC. Subsequently, after an hour, the normal group received normal water via gavage, while groups 2–6 were administered absolute ethanol via gavage. Treatment with PC-1 extract formulation significantly mitigated ethanol-induced gastric injuries, as demonstrated through improved gastric mucus secretion, pH levels, reduced ulceration size, and decreased infiltration of leukocytes in submucosal layer. Analysis of stomach epithelial homogenate revealed a significant upsurge in the superoxide dismutase, catalase, and glutathione, along with a notable decrease in malondialdehyde (MDA) levels upon treatment with PC-1 formulation. The observed gastroprotective effects of PC-1 formulation could be attributed to its capacity to improve pH and mucus secretion, elevate SOD, GSH, and CAT levels, while reducing MDA levels.
Biosynthesis of CuO Nanoparticles using Coleus Aromaticus Leaf Extract for Efficient Catalytic Applications
Authors: Kalaivani P. , Mathubala G.
Published: November 2024

In today's world, the necessity to create economical and ecologically friendly processes has led to a huge increase in interest in the biosynthesis of CuO nanoparticles. Biosynthesis has been proposed as a route to developing various types of nanomaterials. This paper used a leaf extract of Coleus aromaticus as a reductant and stabilizing agent to employ a biosynthesis method to synthesize copper oxide nanoparticles. PXRD revealed the average particle size of the copper oxide nanoparticle is 30 nm. The absorption peak at 564 nm validated the UV-Vis spectra used to identify the production of copper oxide nanoparticles. The absorption peaks of the green synthesized CuO nanoparticles occur at 611 cm-1, matching CuO stretching, indicating the formation of CuO nanoparticles. TGA was used to evaluate the material's thermal stability with CuO nanoparticles. Using SEM and TEM, the CuO nanoparticle's surface morphology, and spherical structure were investigated, and the copper oxide nanoparticles' average diameter was only 34.4 nm. In addition, the obtained CuO nanoparticles were used as efficient catalysis for synthesizing diphenyl ether via the Ullmann coupling reaction. 1H and 13C NMR spectroscopy, Fourier-transformed infrared spectroscopy analysis, and UV-vis spectroscopy confirmed the produced diphenyl ether. The CuO nanoparticles synthesized using the Coleus aromaticus leaf extract technique produced a high yield of diphenyl ether. The outcomes demonstrated that leaf extract could synthesize copper oxide nanoparticles with high uniformity of particle sizes in a more environmentally friendly manner.
Characterization, Synthesis, and Antimicrobial Activities of Quinazoline Derivatives [EMNEDAQZHO]and their Metal Ion Complexes
Authors: Shaikh Sheeba M , R. Wagh Major Rahul.
Published: November 2024

The synthesis, characterization, and antimicrobial evaluation of quinazoline derivatives and their metal ion complexes have garnered significant attention in medicinal chemistry due to their potential therapeutic applications. This study reports the preparation of novel quinazoline derivatives through a deaminative coupling reaction between substituted acetonaphthone and 2-methyl-4H-1,3-benzoxazine-4-one using different amines. Additionally, the coordination behavior of these quinazoline derivatives with metal ions such as Co²⁺, Ni²⁺, Cu²⁺, and Zn²⁺ was explored, resulting in stable metal-ligand complexes. The structural and physico-chemical properties of the synthesized ligand [EMNEDAQZHO] and its metal complexes were analyzed using a combination of volumetric techniques and advanced characterization methods, including FTIR, ¹H NMR, UV-Vis, TGA, and mass spectrometry. Thermogravimetric analysis (TGA) was employed to assess thermal stability, metal content, and moisture loss in the complexes. The antimicrobial activities of the quinazoline Schiff base ligand [EMNEDAQZHO] and its metal complexes were evaluated against a range of bacterial and fungal strains, with minimum inhibitory concentrations (MIC) determined at varying concentrations. This study successfully demonstrates the synthesis of quinazoline derivatives [AMQZHO] and Schiff base [EMNEDAQZHO], as well as their metal ion complexes, through both established and novel synthetic methodologies. The antimicrobial assays revealed that coordination with metal ions significantly enhances the biological activity of the ligands, making these complexes promising candidates for the development of new antimicrobial agents in pharmaceutical applications.
DESAFIOS DA CRIATIVIDADE: EXPLORANDO TROCAS SOCIAIS EM ECOSSISTEMAS CRIATIVOS
Authors: Miri Daniel Hank , Macke Janaina
Published: November 2024

O objetivo do estudo foi analisar os desafios para a realização de trocas sociais em um ecossistema criativo. As trocas sociais compreendem elementos das relações humanas que são exercitados em eventos como o Dia Mundial da Criatividade. O método do artigo se caracteriza como qualitativo exploratório com a aplicação de uma entrevista semiestruturada com 26 participantes, entre organizadores, palestrantes e ouvintes, do evento em Caxias do Sul (RS). A pesquisa identificou que: (i) as características do ambiente de trabalho influenciam as trocas; (ii) as ações e práticas criativas devem ser incentivadas para além dos eventos sobre criatividade; (iii) o ecossistema criativo tem que possibilitar informações e experiências entre os profissionais para que possa facilitar a inovação nas empresas. Este estudo contribui para a compreensão da dinâmica dos ecossistemas criativos e como estes podem proporcionar informações e experiências para orquestração da criatividade nas empresas.
ANÁLISE DA RELAÇÃO ENTRE PERCEPÇÃO DA CORRUPÇÃO E FELICIDADE AUTORREPORTADA NA AMÉRICA LATINA
Authors: Franchini Maria das Graças , Teixeira Evandro Camargos , Soares Laís De Sousa Abreu
Published: November 2024

O nível de bem-estar da população é parâmetro fundamental para que seja possível qualificar o processo de desenvolvimento econômico de determinado país. Por se tratar de um fator subjetivo e de difícil mensuração, empiricamente, o nível de bem-estar tem como proxy usual a felicidade autorreportada pelos indivíduos. Nesse sentido, a Economia da Felicidade vem ganhando espaço como uma corrente que procura relacionar fatores socioeconômicos ao nível de bem-estar autorreportado. Destarte, no presente estudo, buscou-se analisar a relação entre percepção das práticas de corrupção, relacionadas tanto ao setor público quanto privado e à sociedade em geral, dos indivíduos latino-americanos sobre sua felicidade autorreportada, por meio da estimação de um modelo econométrico Probit Ordenado, empregando-se dados obtidos na 7ª Onda da World Values Survey (WVS), realizada entre os anos de 2017 e 2022. Como resultados, foi possível verificar que a percepção da corrupção não é capaz de exercer influência significativa sobre a felicidade autorreportada.
Wit and wisdom: using computational humor to communicate about economics
Authors: Postavaru Iacob , Bunea Emilia , Pungulescu Crina , Stolin David
Published: November 2024

This paper explores the potential of large language models to enhance economics education through computational humor. We employ OpenAI’s GPT-4 model to infuse humor into summaries of three Nobel laureates’ contributions to economics and conduct a small empirical exercise with undergraduate students to test the pedagogical efficacy of computational humor. The results suggest that computer-generated humor may be an effective learning aid: the results of the students who rate the humorous versions of the instructional texts as genuinely funny are significantly better than the results of their peers who are not amused. Encouragingly for teachers who try to be funny but fail, we do not find evidence that ineffectual humor is detrimental to learning.
A new beginning? Obstacles and debates at the relaunch of the Argentine Nuclear Program (1999-2015)
Authors: Rodriguez Milagros Rocio
Published: November 2024

In the 1990's, experts predicted that a ‘Nuclear Renaissance’ would take place in the 21st century, bringing nuclear energy back onto public agendas. This forecast was based on the increase in energy consumption in some Asian countries and the rise in oil prices. In this context, Argentine governments tried to relaunch the nuclear program, which had been paralyzed in 1994. After the recovery from the economic crisis of 2001 and the increase in electricity demand, the energy supply became a crucial aspect of public policies. However, it soon became clear that it was not an easy task. Through the analysis of official legislation, institutional sources and interviews, this paper will explore the main milestones of the relaunch of the Argentine Nuclear Program, as well as the limitations of such planning. We propose that after 2003 the government redefined the role of the actors without questioning the institutional panorama inherited from 1994 and paying little attention to the structural transformations that the sector had undergone after the 1990s. Although a nuclear program for the medium and long term was outlined, said planning was based on immediate political considerations rather than a strategic perspective. That’s why certain objectives, such as the installation of a fourth nuclear power plant or the promotion of the local industry, could not be sustained in the long term.
Brazilian Joyce: An Analysis of Slang in the Brazilian Translations of Ulysses
Authors: Vilela-Jones Camille
Published: November 2024

ABSTRACT: James Joyce's novel Ulysses is known for several factors, including its several translations into many different languages across the globe. I offer a linguistic and cultural analysis of slang terms in the three current translations of the text into Brazilian Portuguese in terms of their domestication and foreignization, terms developed by the translation theorist Lawrence Venuti. This discussion reveals postcolonial and political connections between Ireland and Brazil, as both countries share a colonial past. Their relationship becomes clear when foreignizing translators choose to defamiliarize the text to readers by selecting words that may seem uncommon to the average reader or a lexicon from indigenous and African languages, both cultures strongly present in the Brazilian Portuguese vernacular.
Believing in Mr. W.H.: Spontaneous and Intermental thought in "The Portrait of Mr. W.H."
Authors: Shane Anna
Published: November 2024

abstract: Oscar Wilde's "The Portrait of Mr. W.H." is concerned with the question of what it means to believe. Certain aspects and characteristics of belief as depicted in this story rely on a cognitive approach to identify its phenomenological qualities and how it operates. Wilde depicts belief as belonging to a unique kind of creative thought that is non-conscious, irrational, and collective. While cognition is typically understood as controlled, purposeful, goal-directed, independent and private, this discussion introduces two cognitive categories, spontaneous thought and intermental thought, to conceptualize aspects of cognition that are outside conscious control, opaque or inaccessible, aimless, communal, and reliant upon others. These categories reveal the ways that Wilde puts pressure on conventional definitions of, and assumptions about, belief and art in "The Portrait of Mr. W.H."
Speaking with the Dead: Resurrective Reading and Pneumatological Imagination in George MacDonald
Authors: Vernon Amanda
Published: November 2024

abstract: This essay examines George MacDonald's representation of reading as a conversation with the dead. It argues that MacDonald's notion of resurrective reading is both a subversion of Spiritualist discourse, and an invitation to practice an attentive mode of reading that, while critically engaged, remains open to the unfamiliar and unpredictable. By analyzing MacDonald's model of resurrective reading with particular reference to Phantastes (1858), David Elginbrod (1863), and Donal Grant (1883), this essay reveals the spiritual potential that Victorians like MacDonald associated with the act of reading. It thus demonstrates how attending to the nuances of theology in twenty-first-century readings of Victorian literature provides a fuller understanding of the period's reading practices.
Quantitative investigations on light emission profiles for interstitial laser treatment
Authors: Ta Minh Duc , Kim Yeongeun , Shin Hwarang , Truong Van Gia , Kang Hyun Wook
Published: November 2024

Interstitial laser treatment (ILT) using a diffusing applicator (DA) has been employed to treat tumors. However, the treatment efficacy and safety of the emission profiles from DAs have been poorly explored. This study investigated the effect of the emission profiles from DAs on prostate tumor treatment. Dual-peak and proximal-/distal-end peak profiles using 980 nm laser at 5 W for 60 s were tested to compare the extent of thermal coagulation in soft tissue numerically and experimentally. The numerical simulation predicted the temperature development in the tissue. Ex vivo porcine liver and in vivo rat models were used to compare the performance of the profiles. The dual-peak profile yielded a coagulation extent that was almost equivalent to that of the flat-top profile (in simulation) and 1.3 times larger than those of the other profiles in both ex vivo and in vivo. The dual-peak profile predictably entailed uniform coagulation within the irradiated region. Further in vivo studies using different tumor sizes will be evaluated to warrant the efficacy and safety of the dual-peak profile for the ILT of prostate tumors.
Development of a label-free, functional, molecular and structural imaging system combining optical coherence tomography and Raman spectroscopy for in vivo measurement of rat retina
Authors: Sentosa Ryan , Salas Matthias , Merkle Conrad W. , Eibl Matthias , de Jong Wim , Amelink Arjen , Schmitt Michael , Krestnikov Igor , Shynkar Vasyl , Kempe Michael , Schmoll Tilman , Baumann Bernhard , Andreana Marco , Unterhuber Angelika , Popp Jürgen , Drexler Wolfgang , Leitgeb Rainer A.
Published: November 2024

In vivo access to molecular information of retinal tissue is considered to play a critical role in enabling early diagnosis of ophthalmic and neurodegenerative diseases. The current gold standard of retina imaging, optical coherence tomography and angiography provides only the retinal morphology and blood perfusion, missing the full spectrum of molecular information. Raman spectroscopy addresses this gap while keeping the investigation non-invasive and label-free. Although previous studies have demonstrated the huge diagnostic potential of combining both modalities for in vivo biological tissue measurement, some have either employed unsafe optical power levels for in vivo retinal measurements or presented results that were negative or contradictory. In this study, we have developed an eye-safe multimodal in vivo label-free imaging system and demonstrate the potential of this device by investigating the retina of a living albino rat. The acquired Raman spectra showed relevant Raman bands in comparison with the previous ex vivo studies. Using this multimodal imaging system for non-invasive retina measurements of transgenic rodents holds the potential to advance the understanding of the pathophysiology of both ophthalmic and neurodegenerative diseases.
Averaging illumination colors of multi-illumination ensembles
Authors: Ma Ruiqing , Xue Ruiqing , Shinomori Keizo
Published: November 2024

Average extraction from multiple similar items in ensemble perception has been demonstrated in a variety of visual features. This study investigated whether the visual system can extract precisely the average illumination color from multi-illumination ensembles. In a two-interval forced choice (2IFC) task of the constant stimulus method, observers were asked to judge whether the color of four identical test illuminations (homogeneous condition) or the average color of four distinct test illuminations (heterogeneous condition) was yellower than the reference illumination D67. Four types of scenes were used: Munsell surfaces only, Munsell surfaces with dark and light gray intervals, respectively, and an image of color patches on a white background. The mean values of the cumulative normal distribution functions fitted to the data under the heterogeneous condition were close to those under the homogeneous condition, indicating that the observer has the ability to precisely extract the average illumination color from a set of illuminations. This suggests that rapid and efficient averaging can also be performed in the high-level illumination estimation task.