bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring Maternal Self-Efficacy of First-Time Mothers among Rural-to-Urban Floating Women: A Quantitative Longitudinal Study in China
Authors: Wang Qun , Zhang Yao , Li Xilin , Ye Ziwen , Huang Lingling , Zhang Yan , Zheng Xujuan
Published: March 2021

(1) Background: China has the highest number of rural-to-urban floating women in the world, and the majority of them are of childbearing age. However, few studies have focused on maternal self-efficacy (MSE) for these women. This research aims to explore MSE and its influencing factors for primiparous women among the rural-to-urban floating population in China. (2) Methods: A quantitative longitudinal study was conducted, and primiparous women from the floating population were recruited in China. Face-to-face demographic questionnaires were collected from obstetric wards by the researchers, three days postpartum. The 6-week and 12-week questionnaires, including the Self-efficacy in Infant Care Scale (SICS), the Edinburgh Postnatal Depression Scale (EPDS), and the Postpartum Social Support Scale (PSSS), were sent to participants by wechat or email to measure MSE, postnatal depression, and social support, respectively. The completed 6-week and completed 12-week questionnaires were returned to the researchers. (3) Results: The mean MSE scores at 6 and 12 weeks postpartum were 67.16 (SD = 14.35) and 68.71 (SD = 15.00). The variables of social support, postnatal depression, whether women attended parenting training, baby fussiness, baby health, maternal educational level, occupation, and family income affected MSE at the two time points. (4) Conclusions: Primiparous women among the rural-to-urban floating population had a low MSE level. As a vulnerable and special group, more attention should be paid to the negative parenting status of floating women by health workers and family members. Effective measures must be taken to improve the floating women’s accessibility to parenting training from health services to strengthen their social support and alleviate postpartum depression. Health professionals should be more concerned with floating women with relatively low MSE levels, such as new mothers with lower education, poor working and living conditions, unhealthy babies, and babies with fussy temperaments.
A Review of Heavy Metals in Coastal Surface Sediments from the Red Sea: Health-Ecological Risk Assessments
Authors: Al-Mutairi Khalid Awadh , Yap Chee Kong
Published: March 2021

The heavy metal (HM) pollution in sediment is of serious concern, particularly in the Red Sea environment. This study aimed to review and compile data on the concentrations of four HMs (Cd, Cu, Pb, and Zn) in the coastal surface sediments from the Red Sea, mainly from Saudi Arabia, Egypt, and Yemen, published in the literature from 1992 to 2021. The coastal sediments included those from mangrove, estuaries, and intertidal ecosystems. It was found that the mean values of Cd, Cu, Pb, and Zn in coastal Red Sea sediments were elevated and localized in high human activity sites in comparison to the earth upper continental crust and to reference values for marine sediments. From the potential ecological risk index (PERI) aspect, 32 reports (47.1%) were categorized as ‘considerable ecological risk’ and 23 reports (33.8%) as ‘very high ecological risk’. From the human health risk assessment (HHRA) aspect, the non-carcinogenic risk (NCR) values (HI values < 1.0) of Cd, Cu, Pb, and Zn represented no NCR for the ingestion and the dermal contact routes for sediments from the Red Sea countries. The reassessment of the HM data cited in the literature allowed integrative and accurate comparisons of the PERI and HHRA data, which would be useful in the management and sustainable development of the Red Sea area, besides being a helpful database for future use. This warrants extensive and continuous monitoring studies to understand the current and the projected HM pollution situation and to propose possible protective and conservative measures in the future for the resource-rich Red Sea ecosystem.
The Brief COPE: Measurement Invariance and Psychometric Properties among Community and At-Risk Portuguese Parents
Authors: Nunes Cristina , Pérez-Padilla Javier , Martins Cátia , Pechorro Pedro , Ayala-Nunes Lara , Ferreira Laura I.
Published: March 2021

Parenting generally brings about high internal and external demands, which can be perceived as stressful when they exceed families’ resources. When faced with such stressors, parents need to deploy several adaptive strategies to successfully overcome these challenges. One of such strategies is coping, an important cognitive and behavioural skill. In this study, we intended to examine the psychometric properties of Carver’s (1997) Brief COPE (Coping Orientation to Problems Experienced), extending its cross-cultural validity among a Portuguese sample of community and at-risk parents. The sample comprised community (n = 153) and at-risk (n = 116) parents who completed the brief COPE, the Family Adaptability and Cohesion Scales and the Parenting Stress Index—Short Form. Confirmatory factor analysis, internal consistency, cross sample invariance, convergent and discriminant validity were analysed. Data from the confirmatory factor analysis revealed that the 14-factor model obtained the best fit. The results provided evidence that the Brief COPE is a psychometrically sound instrument that shows measurement invariance across samples and good reliability. Our findings demonstrated that the Portuguese version of brief COPE is a useful, time-efficient tool for both practitioners and researchers who need to assess coping strategies, a relevant construct in family context.
Multilevel Analysis of the Association of Dental-Hygienist-Related Factors on Regular Dental Check-Up Behavior
Authors: Inoue Yuko , Shimazaki Yoshihiro , Oshiro Akiko , Zaitsu Takashi , Furuta Michiko , Ando Yuichi , Miyazaki Hideo , Kambara Masaki , Fukai Kakuhiro , Aida Jun
Published: March 2021

Few studies have examined the factors related to dental clinics during dental check-ups. We examined the association between dental-hygienist-related factors and patients’ regular dental check-ups. This nationwide cross-sectional study was based on a survey conducted in Japan in 2014. The analyzed population included 12,139 patients from 1181 dental clinics. We used three-level Poisson regression analysis, considering patient‒clinic‒prefecture, to examine the association of dental-hygienist-related factors with dental check-up behavior. Patients attending treatment and regular check-ups constituted 63.0% and 37.0%, respectively. The adjusted prevalence ratios (PRs) for patients undergoing regular dental check-ups at dental clinics with dedicated dental hygienists’ units, spending ≥20 min in patient education (compared to 0 min), and with three or more dental hygienists (compared to 0 hygienists) available were 1.17 (95% confidence interval [CI]: 1.06–1.30), 1.25 (95%CI: 1.07–1.46), and 2.05 (95%CI: 1.64–2.56), respectively. The median PR indicates that when a patient randomly moves to another dental clinic with more regular dental check-ups, this prevalence increased 1.69 times. These results suggest that dental check-up behavior is determined not only by individual factors but also dental-clinic-level factors. Improving the dental-hygienist-related factors is necessary to encourage people to visit dentists for regular check-ups.
Social and Built Environments Related to Cognitive Function of Older Adults: A Multi-Level Analysis Study in Taiwan
Authors: Hsu Hui-Chuan , Bai Chyi-Huey
Published: March 2021

The purpose of this study was to examine the associations between cognitive function, the city’s social environment, and individual characteristics of older adults. The individual data of older people were from the Nutrition and Health Survey in Taiwan 2013–2016. The participants who were aged 65 and above were included in the analysis (n = 1356). City-level data were obtained for twenty cities in Taiwan. The data of city-level indicators were from governmental open data and Taiwan’s Age Friendly Environment Monitor Study. A multilevel mixed-effect model was applied in the analysis. Population density, median income, safety in the community, barrier-free sidewalks, high education rate of the population, low-income population rate, household income inequality, and elderly abuse rate were related to cognitive function in the bivariate analysis. When controlling for individual factors, the city’s low-income population rate was still significantly related to lower cognitive function. In addition, the participants who were at younger age, had a higher education level, had a better financial satisfaction, had worse self-rated health, had higher numbers of disease, and had better physical function had better cognitive function. Social and built environments associated with cognitive function highlight the importance of income security and the age friendliness of the city for older adults. Income security for older people and age-friendly city policies are suggested.
Insights Gained from an Approximate Analytical Solution of the Evaporation Model Used by ConsExpo Web
Authors: Schendel Thomas , Rogasch Eva Charlotte
Published: March 2021

Evaporation of chemicals is an important source of inhalative exposure. We analyzed here the ConsExpo evaporation model, which is characterized by a set of nonlinear differential equations only solvable by numerical means. It shows qualitatively different behavior for different parameters, but the exact conditions remain unclear. This article presents an approximate analytical solution of the ConsExpo evaporation model, derived by using a specific linearization of the nonlinear equations valid for small concentrations. From this solution, three different boundary cases or regimes are found: quick release, near equilibrium, and ventilation driven regime. Depending on the evaporation regime, different parameters influence peak substance air concentration: Quick release regime: total substance amount and room volume; near equilibrium regime: vapor pressure, substance concentration in the product, and molecular weight of the product matrix; ventilation driven regime: vapor pressure, substance concentration in the product, room volume, surface area, mass transfer coefficient, ventilation rate, and molecular weight of the product matrix. A graphical method is developed to display the position of a given scenario in relation to the three regimes. Thus, the approximate analytical solution allows for a given situation to prioritize research for reducing uncertainty of the most sensitive parameters and helps to identify promising risk management measures.
Foreign Direct Investment’s Impact on China’s Economic Growth, Technological Innovation and Pollution
Authors: Zeng Shihong , Zhou Ya
Published: March 2021

In recent years, China has gradually become one of the countries with the largest levels of foreign direct investment (FDI). FDI has played a significant role in promoting Chinese economic development, and the FDI technology spillover effect is one of the core forces driving China towards reaching new growth milestones. Therefore, due to the country’s interest in development, there is competition for FDI throughout China. However, the existing imperfect environmental protection system cannot prevent FDI from flowing into China’s highly polluting and resource-intensive industrial chain, possibly causing serious environmental problems. Therefore, the topic of properly introducing foreign capital to promote development and effectively end China’s current environmental pollution crisis has become a research focus. To explore FDI’s impact on China’s economic growth, technological innovation, and environmental pollution, we use Chinese provincial panel data for 2004–2016 to construct a dynamic panel simultaneous-equation model. Considering the interrelationships between the equations, we construct economic models of economic growth, technological innovation, and pollution emissions, and incorporate them into the same research system for generalized method of moments (GMM) estimation. Our results show that FDI has a significant and positive direct impact on China’s economic growth and technological innovation, and can furthermore have a significant pull effect on the domestic economy through the backward spillover channel. At the same time, FDI has a direct and significant impact on the increase in regional waste-water discharge, while exhibiting a pollution halo effect on the emission of sulfur dioxide (SO2) and chemical oxygen demand (COD) emissions directly. In addition, we observe “benign feedback mechanism” between technological innovation output and these three types of pollution, namely SO2 emission, COD emissions, and ammonia and nitrogen discharge.
Vitamin D Compounds PRI-2191 and PRI-2205 Enhance Anastrozole Activity in Human Breast Cancer Models
Authors: Filip-Psurska Beata , Psurski Mateusz , Anisiewicz Artur , Libako Patrycja , Zbrojewicz Ewa , Maciejewska Magdalena , Chodyński Michał , Kutner Andrzej , Wietrzyk Joanna
Published: March 2021

1,25-Dihydroxycholecalciferol, the hormonally active vitamin D3 metabolite, is known to exhibit therapeutic effects against breast cancer, mainly by lowering the expression of estrogen receptors and aromatase activity. Previously, the safety of the vitamin D active metabolite (24R)-1,24-dihydroxycholecalciferol (PRI-2191) and 1,25(OH)2D3 analog PRI-2205 was tested, and the in vitro activity of these analogs against different cancer cell lines was studied. We determined the effect of the two vitamin D compounds on anastrozole (An) activity against breast cancer based on antiproliferative activity, ELISA, flow cytometry, enzyme inhibition potency, PCR, and xenograft study. Both the vitamin D active metabolite and synthetic analog regulated the growth of not only estrogen receptor-positive cells (T47D and MCF-7, in vitro and in vivo), but also hormone-independent cancer cells such as SKBR-3 (HER-2-positive) and MDA-MB-231 (triple-negative), despite their relatively low VDR expression. Combined with An, PRI-2191 and PRI-2205 significantly inhibited the tumor growth of MCF-7 cells. Potentiation of the antitumor activity in combined treatment of MCF-7 tumor-bearing mice is related to the reduced activity of aromatase by both An (enzyme inhibition) and vitamin D compounds (switched off/decreased aromatase gene expression, decreased expression of other genes related to estrogen signaling) and by regulation of the expression of the estrogen receptor ERα and VDR.
The Leukotriene Receptor Antagonist Montelukast Attenuates Neuroinflammation and Affects Cognition in Transgenic 5xFAD Mice
Authors: Michael Johanna , Zirknitzer Julia , Unger Michael Stefan , Poupardin Rodolphe , Rieß Tanja , Paiement Nadine , Zerbe Horst , Hutter-Paier Birgit , Reitsamer Herbert , Aigner Ludwig
Published: March 2021

Alzheimer’s disease (AD) is the most common form of dementia. In particular, neuroinflammation, mediated by microglia cells but also through CD8+ T-cells, actively contributes to disease pathology. Leukotrienes are involved in neuroinflammation and in the pathological hallmarks of AD. In consequence, leukotriene signaling—more specifically, the leukotriene receptors—has been recognized as a potential drug target to ameliorate AD pathology. Here, we analyzed the effects of the leukotriene receptor antagonist montelukast (MTK) on hippocampal gene expression in 5xFAD mice, a commonly used transgenic AD mouse model. We identified glial activation and neuroinflammation as the main pathways modulated by MTK. The treatment increased the number of Tmem119+ microglia and downregulated genes related to AD-associated microglia and to lipid droplet-accumulating microglia, suggesting that the MTK treatment targets and modulates microglia phenotypes in the disease model compared to the vehicle. MTK treatment further reduced infiltration of CD8+T-cells into the brain parenchyma. Finally, MTK treatment resulted in improved cognitive functions. In summary, we provide a proof of concept for MTK to be a potential drug candidate for AD and provide novel modes of action via modulation of microglia and CD8+ T-cells. Of note, 5xFAD females showed a more severe pathology, and in consequence, MTK treatment had a more pronounced effect in the females compared to the males. The effects on neuroinflammation, i.e., microglia and CD8+ T-cells, as well as the effects on cognitive outcome, were dose-dependent, therefore arguing for the use of higher doses of MTK in AD clinical trials compared to the approved asthma dose.
Emerging Role of AP-1 Transcription Factor JunB in Angiogenesis and Vascular Development
Authors: Yoshitomi Yasuo , Ikeda Takayuki , Saito-Takatsuji Hidehito , Yonekura Hideto
Published: March 2021

Blood vessels are essential for the formation and maintenance of almost all functional tissues. They play fundamental roles in the supply of oxygen and nutrition, as well as development and morphogenesis. Vascular endothelial cells are the main factor in blood vessel formation. Recently, research findings showed heterogeneity in vascular endothelial cells in different tissue/organs. Endothelial cells alter their gene expressions depending on their cell fate or angiogenic states of vascular development in normal and pathological processes. Studies on gene regulation in endothelial cells demonstrated that the activator protein 1 (AP-1) transcription factors are implicated in angiogenesis and vascular development. In particular, it has been revealed that JunB (a member of the AP-1 transcription factor family) is transiently induced in endothelial cells at the angiogenic frontier and controls them on tip cells specification during vascular development. Moreover, JunB plays a role in tissue-specific vascular maturation processes during neurovascular interaction in mouse embryonic skin and retina vasculatures. Thus, JunB appears to be a new angiogenic factor that induces endothelial cell migration and sprouting particularly in neurovascular interaction during vascular development. In this review, we discuss the recently identified role of JunB in endothelial cells and blood vessel formation.
Danegaptide Prevents TGFβ1-Induced Damage in Human Proximal Tubule Epithelial Cells of the Kidney
Authors: Squires Paul E. , Price Gareth W. , Mouritzen Ulrik , Potter Joe A. , Williams Bethany M. , Hills Claire E.
Published: March 2021

Chronic kidney disease (CKD) is a global health problem associated with a number of comorbidities. Recent evidence implicates increased hemichannel-mediated release of adenosine triphosphate (ATP) in the progression of tubulointerstitial fibrosis, the main underlying pathology of CKD. Here, we evaluate the effect of danegaptide on blocking hemichannel-mediated changes in the expression and function of proteins associated with disease progression in tubular epithelial kidney cells. Primary human proximal tubule epithelial cells (hPTECs) were treated with the beta1 isoform of the pro-fibrotic cytokine transforming growth factor (TGFβ1) ± danegaptide. qRT-PCR and immunoblotting confirmed mRNA and protein expression, whilst a cytokine antibody array assessed the expression/secretion of proinflammatory and profibrotic cytokines. Carboxyfluorescein dye uptake and ATP biosensing measured hemichannel activity and ATP release, whilst transepithelial electrical resistance was used to assess paracellular permeability. Danegaptide negated carboxyfluorescein dye uptake and ATP release and protected against protein changes associated with tubular injury. Blocking Cx43-mediated ATP release was paralleled by partial restoration of the expression of cell cycle inhibitors, adherens and tight junction proteins and decreased paracellular permeability. Furthermore, danegaptide inhibited TGFβ1-induced changes in the expression and secretion of key adipokines, cytokines, chemokines, growth factors and interleukins. The data suggest that as a gap junction modulator and hemichannel blocker, danegaptide has potential in the future treatment of CKD.
IgGs-Abzymes from the Sera of Patients with Multiple Sclerosis Recognize and Hydrolyze miRNAs
Authors: Ermakov Evgeny A. , Kabirova Evelina M. , Buneva Valentina N. , Nevinsky Georgy A.
Published: March 2021

Autoantibodies-abzymes hydrolyzing DNA, myelin basic protein, and oligosaccharides have been revealed in the sera of patients with multiple sclerosis (MS). In MS, specific microRNAs are found in blood and cerebrospinal fluid, which are characterized by increased expression. Autoantibodies, specifically hydrolyzing four different miRNAs, were first detected in the blood of schizophrenia patients. Here, we present the first evidence that 23 IgG antibodies of MS patients effectively recognize and hydrolyze four neuroregulatory miRNAs (miR-137, miR-9-5p, miR-219-2-3p, and miR-219-5p) and four immunoregulatory miRNAs (miR-21-3p, miR-146a-3p, miR-155-5p, and miR-326). Several known criteria were checked to show that the recognition and hydrolysis of miRNAs is an intrinsic property of MS IgGs. The hydrolysis of all miRNAs is mostly site-specific. The major and moderate sites of the hydrolysis of each miRNA for most of the IgG preparations coincided; however, some of them showed other specific sites of splitting. Several individual IgGs hydrolyzed some miRNAs almost nonspecifically at nearly all internucleoside bonds or demonstrated a combination of site-specific and nonspecific splitting. Maximum average relative activity (RA) was observed in the hydrolysis of miR-155-5p for IgGs of patients of two types of MS—clinically isolated syndrome and relapsing-remitting MS—but was also high for patients with primary progressive and secondary progressive MS. Differences between RAs of IgGs of four groups of MS patients and healthy donors were statistically significant (p < 0.015). There was a tendency of decreasing efficiency of hydrolysis of all eight miRNAs during remission compared with the exacerbation of the disease.
Strategies to Apply Water-Deficit Stress: Similarities and Disparities at the Whole Plant Metabolism Level in Medicago truncatula
Authors: Castañeda Verónica , González Esther M.
Published: March 2021

Water-deficit stresses such as drought and salinity are the most important factors limiting crop productivity. Hence, understanding the plant responses to these stresses is key for the improvement of their tolerance and yield. In this study M. truncatula plants were subjected to 250 mM NaCl as well as reduced irrigation (No-W) and 250 g/L polyethylene glycol (PEG)-6000 to induce salinity and drought stress, respectively, provoking a drop to −1.7 MPa in leaf water potential. The whole plant physiology and metabolism was explored by characterizing the stress responses at root, phloem sap and leaf organ level. PEG treatment led to some typical responses of plants to drought stress, but in addition to PEG uptake, an important impairment of nutrient uptake and a different regulation of carbon metabolism could be observed compared to No-W plants. No-W plants showed an important redistribution of antioxidants and assimilates to the root tissue, with a distinctive increase in root proline degradation and alkaline invertase activity. On the contrary, salinity provoked an increase in leaf starch and isocitrate dehydrogenase activity, suggesting key roles in the plant response to this stress. Overall, results suggest higher protection of salt-stressed shoots and non-irrigated roots through different mechanisms, including the regulation of proline and carbon metabolism, while discarding PEG as safe mimicker of drought. This raises the need to understand the effect at the whole plant level of the different strategies employed to apply water-deficit stress.
Mitochondrial Consequences of Organ Preservation Techniques during Liver Transplantation
Authors: Horváth Tamara , Jász Dávid Kurszán , Baráth Bálint , Poles Marietta Zita , Boros Mihály , Hartmann Petra
Published: March 2021

Allograft ischemia during liver transplantation (LT) adversely affects the function of mitochondria, resulting in impairment of oxidative phosphorylation and compromised post-transplant recovery of the affected organ. Several preservation methods have been developed to improve donor organ quality; however, their effects on mitochondrial functions have not yet been compared. This study aimed to summarize the available data on mitochondrial effects of graft preservation methods in preclinical models of LT. Furthermore, a network meta-analysis was conducted to determine if any of these treatments provide a superior benefit, suggesting that they might be used on humans. A systematic search was conducted using electronic databases (EMBASE, MEDLINE (via PubMed), the Cochrane Central Register of Controlled Trials (CENTRAL) and Web of Science) for controlled animal studies using preservation methods for LT. The ATP content of the graft was the primary outcome, as this is an indicator overall mitochondrial function. Secondary outcomes were the respiratory activity of mitochondrial complexes, cytochrome c and aspartate aminotransferase (ALT) release. Both a random-effects model and the SYRCLE risk of bias analysis for animal studies were used. After a comprehensive search of the databases, 25 studies were enrolled in the analysis. Treatments that had the most significant protective effect on ATP content included hypothermic and subnormothermic machine perfusion (HMP and SNMP) (MD = −1.0, 95% CI: (−2.3, 0.3) and MD = −1.1, 95% CI: (−3.2, 1.02)), while the effects of warm ischemia (WI) without cold storage (WI) and normothermic machine perfusion (NMP) were less pronounced (MD = −1.8, 95% CI: (−2.9, −0.7) and MD = −2.1 MD; CI: (−4.6; 0.4)). The subgroup of static cold storage (SCS) with shorter preservation time (< 12 h) yielded better results than SCS ≥ 12 h, NMP and WI, in terms of ATP preservation and the respiratory capacity of complexes. HMP and SNMP stand out in terms of mitochondrial protection when compared to other treatments for LT in animals. The shorter storage time at lower temperatures, together with the dynamic preservation, provided superior protection for the grafts in terms of mitochondrial function. Additional clinical studies on human patients including marginal donors and longer ischemia times are needed to confirm any superiority of preservation methods with respect to mitochondrial function.
Dynamic Responses of Standard and Poor’s Regional Bank Index to the U.S. Fear Index, VIX
Authors: Adrangi Bahram , Chatrath Arjun , Kolay Madhuparna , Raffiee Kambiz
Published: March 2021

This study examines the reaction of the Standard and Poor’s Regional Bank Index (SPRB) to the U.S. equity market fear index (i.e., the Chicago Board of Trade Volatility Index [VIX]). The VIX is designed to perform as a leading indicator of the volatility in equity markets. However, practitioners observe many periods of divergence between the VIX and S&P 500. Our paper examines the daily data for the period of 2009 through 2019. We show that once the effects of consumer confidence and capacity utilization are accounted for, there is a negative association between the VIX and regional bank performance.
Effective Strategies for Contents Recommendation Based on Psychological Ownership of over the Top Services in Cyberspace
Authors: Seo Bong-Goon , Park Do-Hyung
Published: March 2021

With the advanced development of IT, people are spending an increasing amount of time in the cyberspace and perceive psychological ownership of intangible objects (e.g., e-books, avatars, online movie streaming services), which they come to regard as “theirs”. This study focuses on users’ psychological ownership of OTT (over the top) services, which have recently received much attention, and investigates how service providers can present recommendation information more effectively when recommending content to users. This study, based on psychological ownership theory, specifically attempts to verify which method of recommending information is effective in correlation to the level of psychological ownership that a user feels about an online service. Additionally, this study presents this effect in terms of psychological distance, which we argue is the underlying mechanism of psychological ownership. Watcha, one of South Korea’s OTT services, was employed as the experimental subject in this study, and a scenario-based test was conducted. In conclusion, this study found that for users with high psychological ownership of online services, a recommendation information message based on objective and concrete information about a movie was more effective, whereas for users with low psychological ownership, abstractly expressed messages were more effective. Furthermore, by applying a moderated mediation model, this study confirmed that psychological distance mediated the results stated above.
Preparation and Characterization of Fish Skin Collagen Material Modified with β-Glucan as Potential Wound Dressing
Authors: Michalska-Sionkowska Marta , Warżyńska Oliwia , Kaczmarek-Szczepańska Beata , Łukowicz Krzysztof , Osyczka Anna Maria , Walczak Maciej
Published: March 2021

Collagen possesses unique properties, e.g., biocompatibility, biodegradability, and non-toxicity. However, collagen material degrades too quickly and has low mechanical properties. One of the methods of polymers’ modification is mixing them to obtain blends. In this study, the influence of β-glucan for collagen material was analyzed. The interaction between the functional groups of the polymer was analyzed by ATR-FTIR (attenuated total reflection-fourier transform infrared) spectroscopy. The influence of β-glucan on mechanical properties was evaluated. The surface properties of materials were assessed using contact angle measurements and the topography of materials was evaluated by AFM (atomic force microscope). The structure of materials was analyzed according to SEM (scanning electron microscopy) pictures. Moreover, the DPPH-free radicals’ scavenging ability and biocompatibility against erythrocytes and HaCaT cells were evaluated. Collagen and β-glucan were bound together by a hydrogen bond. β-glucan addition increased the roughness of the surface of the film and resulted in a more rigid character of the materials. A small addition of β-glucan to collagen provided a more hydrophilic character. All the materials could swell in in vitro conditions and showed antioxidant activity. Materials do not cause erythrocyte hemolysis. Finely, our cytotoxicity studies indicated that β-glucan can be safely added at small (10% or less) quantity to collagen matrix, they sufficiently support cell growth, and the degradation products of such matrices may actually provide some beneficial effects to the surrounding cells/tissues.
Effects of SiC Fibers and Laminated Structure on Mechanical Properties of Ti–Al Laminated Composites
Authors: Hou Chenyang , Zhang Shouyin , Ma Zhijian , Lu Baiping , Wang Zhenjun
Published: March 2021

Ti/Ti–Al and SiCf-reinforced Ti/Ti–Al laminated composites were fabricated through vacuum hot-pressure using pure Ti foils, pure Al foils and SiC fibers as raw materials. The effects of SiC fiber and a laminated structure on the properties of Ti–Al laminated composites were studied. A novel method of fiber weaving was implemented to arrange the SiC fibers, which can guarantee the equal spacing of the fibers without introducing other elements. Results showed that with a higher exerted pressure, a more compact structure with fewer Kirkendall holes can be obtained in SiCf-reinforced Ti/Ti–Al laminated composites. The tensile strength along the longitudinal direction of fibers was about 400 ± 10 MPa, which was 60% higher compared with the fabricated Ti/Ti–Al laminated composites with the same volume fraction (60%) of the Ti layer. An in situ tensile test was adopted to observe the deformation behavior and fracture mechanisms of the SiCf-reinforced Ti/Ti–Al laminated composites. Results showed that microcracks first occurred in the Ti–Al intermetallic layer.
Abrasive Sensitivity of Martensitic and a Multi-Phase Steels under Different Abrasive Conditions
Authors: Kalácska Ádám , Székely László , Keresztes Róbert Zsolt , Gábora András , Mankovits Tamás , De Baets Patrick
Published: March 2021

The wear behaviour of two martensitic and one multiphase steel targeted for abrasion and erosion applications in agriculture and mining industry were investigated in three abrasive test systems with different complexity. Scratch tests were performed with different indenter radii, shapes, and loads. The material behaviour was also investigated in multi-asperity contact systems. Pin-on-disc tests were performed with various loads and abrasive particles, as well as abrasive slurry-pot tests with different sliding velocities, distances, and impact angles of the abrasive media were performed. Comparing the test systems, the tested materials ranked similarly based on their wear performance, however, in each configuration, the dominant variable of the wear mechanism differed. The significance and contributions of test paramecenterters, the material’s mechanical properties (H, σM, σY, E, εεM, εεB, W, σc, Ec) and the dimensionless numbers formed from them were investigated on the wear behaviour and the surface deformation. Correlation between parameters was established by multiple linear regression models. The sensitivity of the tested materials to abrasion was evaluated taking into account the wide range of influencing parameters.
The Impact of Water and Road Salt with Anti-Caking Agent on the Stiffness of Select Mixes Used for the Road Surface
Authors: Mackiewicz Piotr , Mączka Eryk
Published: March 2021

An original experimental method was used to investigate the influence of water and road salt with anti-caking agent on the material used in pavement construction layers. This method allowed for monitoring material changes resulting from the influence of water and road salt with anti-caking agent over time. The experiment used five different mineral road mixes, which were soaked separately in water and brine for two time intervals (2 days and 21 days). Then, each sample of the mix was subjected to tests of the complex module using the four-point bending (4PB-PR) method. The increase in mass of the soaked samples and the change in value of the stiffness modulus were analyzed. Exemplary tomographic (X-ray) imaging was performed to confirm the reaction of the road salt and anti-caking agent (lead agent) with the material. Based on measurements of the stiffness modulus and absorption, the correlations of the mass change and the value of the stiffness modulus were determined, which may be useful in estimating the sensitivity of mixes to the use of winter maintenance agents—e.g., road salt with anti-caking agent (sodium chloride). It was found that the greatest changes occur for mixes intended for base course layers (mineral cement mix with foamed asphalt (MCAS) and mineral-cement-emulsion mixes (MCE)) and that the smallest changes occur for mixes containing highly modified asphalt (HIMA).
A Hybrid MCDM Model for Evaluating Open Banking Business Partners
Authors: Daiy Alexander Kuan , Shen Kao-Yi , Huang Jim-Yuh , Lin Tom Meng-Yen
Published: March 2021

Open banking (OB) is an emerging business field in the financial sector, which relies on intensive collaboration between banks and non-banking service providers. However, how to evaluate OB business partners from multiple perspectives for banks is underexplored. Therefore, this study proposed a hybrid decision model with supports from seasoned domain experts. This study also adopts a domestic bank from Taiwan and four non-banking service providers to illustrate the hybrid approach with the confidence-weighted fuzzy assessment technique. The proposed model might be the first attempt to explore the OB adoption strategy by the novel approach. However, its limitations are the presumed independent relationship among the factors of this hybrid model. Additionally, the results hinge upon domain experts’ knowledge. In practice, the research findings identify the relative importance of banks’ crucial factors to select OB strategic partners, which provide managerial insights and valuable guidance for the banking sector.
A Hybrid NF-FO-RO Process for the Supply of Irrigation Water from Treated Wastewater: Simulation Study
Authors: Hafiz MhdAmmar , Alfahel Radwan , Hawari Alaa H. , Hassan Mohammad K. , Altaee Ali
Published: March 2021

Municipal treated wastewater could be considered as a water source for food crop irrigation purposes. Enhancing the quality of treated wastewater to meet irrigation standards has become a necessary practice. Nanofiltration (NF) was used in the first stage to produce permeate at relatively low energy consumption. In the second stage, two membrane combinations were tested for additional water extraction from the brine generated by the NF process. The simulation results showed that using a hybrid forward osmosis (FO)–reverse osmosis (RO) system is more efficient than using the RO process alone for the further extraction of water from the brine generated by the NF process. The total specific energy consumption can be reduced by 27% after using FO as an intermediate process between NF and RO. In addition, the final permeate water quality produced using the hybrid FO-RO system was within the allowable standards for food crops irrigation.
Epidemic HI2 Plasmids Mobilising the Carbapenemase Gene blaIMP-4 in Australian Clinical Samples Identified in Multiple Sublineages of Escherichia coli ST216 Colonising Silver Gulls
Authors: Tarabai Hassan , Wyrsch Ethan R. , Bitar Ibrahim , Dolejska Monika , Djordjevic Steven P.
Published: March 2021

Escherichia coli ST216, including those that carry blaKPC-2, blaFOX-5, blaCTX-M-15 and mcr-1, have been linked to wild and urban-adapted birds and the colonisation of hospital environments causing recalcitrant, carbapenem-resistant human infections. Here we sequenced 22 multiple-drug resistant ST216 isolates from Australian silver gull chicks sampled from Five Islands, of which 21 carried nine or more antibiotic resistance genes including blaIMP-4 (n = 21), blaTEM-1b (n = 21), aac(3)-IId (n = 20), mph(A) (n = 20), catB3 (n = 20), sul1 (n = 20), aph(3”)-Ib (n = 18) and aph(6)-Id (n = 18) on FIB(K) (n = 20), HI2-ST1 (n = 11) and HI2-ST3 (n = 10) plasmids. We show that (i) all HI2 plasmids harbour blaIMP-4 in resistance regions containing In809 flanked by IS26 (HI2-ST1) or IS15DI (HI2-ST3) and diverse metal resistance genes; (ii) HI2-ST1 plasmids are highly related to plasmids reported in diverse Enterobacteriaceae sourced from humans, companion animals and wildlife; (iii) HI2 were a feature of the Australian gull isolates and were not observed in international ST216 isolates. Phylogenetic analyses identified close relationships between ST216 from Australian gull and clinical isolates from overseas. E. coli ST216 from Australian gulls harbour HI2 plasmids encoding resistance to clinically important antibiotics and metals. Our studies underscore the importance of adopting a one health approach to AMR and pathogen surveillance.
Apple Pomace and Performance, Intestinal Morphology and Microbiota of Weaned Piglets—A Weaning Strategy for Gut Health?
Authors: Dufourny Sandrine , Antoine Nadine , Pitchugina Elena , Delcenserie Véronique , Godbout Stéphane , Douny Caroline , Scippo Marie-Louise , Froidmont Eric , Rondia Pierre , Wavreille José , Everaert Nadia
Published: March 2021

Apple pomace (AP) is known to be rich in biomolecules beneficial for health and it may advantageously be used to overcome the critical step of piglets’ weaning. The study aimed to determine the effect of two levels of incorporation of AP on the performance, intestinal morphology, and microbiota of weaned piglets and investigate this feed ingredient as a weaning strategy. An experiment was performed with 42 piglets from weaning (28 days old) over a five-week period, including three iso-energetic and iso-nitrogenous diets (0%, 2%, and 4% dried AP diets) with seven pen-repetitions per diet (two pigs per pen). AP diets were beneficial for the average daily gain calculated on week 3 (p = 0.038) and some parameters of the intestinal architecture on the 35 post-weaning day. The 4% AP diet was beneficial for the feed conversion ratio (p = 0.002) and the energetic feed efficiency (p = 0.004) on the 35 post-weaning day. AP tended to influence the consistency of feces (softer to liquid, p = 0.096) and increased the counts of excreted pathogens (p = 0.072). Four percent AP influenced the richness of the microbiota and the bacteria profile as observed for the phylum Bacteroidetes or the class Clostridia. The 4% AP diet appeared as an interesting weaning strategy that should be evaluated in a large cohort.
Application of Green Solvents for Rare Earth Element Recovery from Aluminate Phosphors
Authors: Yen Clive H. , Cheong Rui
Published: March 2021

Two processes applying green solvents for recovering rare earth elements (REEs) from different types of aluminate phosphors are demonstrated in this report. For magnesium aluminate-type phosphors, a pretreatment with peroxide calcination was implemented first, and then followed by a supercritical fluid extraction (SFE) process. Supercritical carbon dioxide (sc-CO2) provides an effective and green medium for extracting REEs from dry materials. With the addition of a complex agent, tri-n-butyl phosphate-nitric acid complex, highly efficient and selective extraction of REEs using supercritical carbon dioxide can be achieved. The highest extraction efficiency was 92% for europium from the europium doped barium magnesium aluminate phosphor (BAM), whereas the highest extraction selectivity was more than 99% for the REEs combined from the trichromatic phosphor. On the other hand, for strontium aluminate type phosphors, a direct acid leaching process is suggested. It was found out that acetic acid, which is considerably green, could have high recovery rate for dysprosium (>99%) and europium (~83%) from this strontium aluminate phosphor materials. Nevertheless, both green processes showed promising results and could have high potential for industrial applications.
Thermal Charging Optimization of a Wavy-Shaped Nano-Enhanced Thermal Storage Unit
Authors: Ghalambaz Mohammad , Mehryan S.A.M. , Hajjar Ahmad , Shdaifat Mohammad Yacoub Al , Younis Obai , Talebizadehsardari Pouyan , Yaïci Wahiba
Published: March 2021

A wavy shape was used to enhance the thermal heat transfer in a shell-tube latent heat thermal energy storage (LHTES) unit. The thermal storage unit was filled with CuO–coconut oil nano-enhanced phase change material (NePCM). The enthalpy-porosity approach was employed to model the phase change heat transfer in the presence of natural convection effects in the molten NePCM. The finite element method was applied to integrate the governing equations for fluid motion and phase change heat transfer. The impact of wave amplitude and wave number of the heated tube, as well as the volume concertation of nanoparticles on the full-charging time of the LHTES unit, was addressed. The Taguchi optimization method was used to find an optimum design of the LHTES unit. The results showed that an increase in the volume fraction of nanoparticles reduces the charging time. Moreover, the waviness of the tube resists the natural convection flow circulation in the phase change domain and could increase the charging time.
Baicalin Represses Type Three Secretion System of Pseudomonas aeruginosa through PQS System
Authors: Zhang Pansong , Guo Qiao , Wei Zhihua , Yang Qin , Guo Zisheng , Shen Lixin , Duan Kangmin , Chen Lin
Published: March 2021

Therapeutics that target the virulence of pathogens rather than their viability offer a promising alternative for treating infectious diseases and circumventing antibiotic resistance. In this study, we searched for anti-virulence compounds against Pseudomonas aeruginosa from Chinese herbs and investigated baicalin from Scutellariae radix as such an active anti-virulence compound. The effect of baicalin on a range of important virulence factors in P. aeruginosa was assessed using luxCDABE-based reporters and by phenotypical assays. The molecular mechanism of the virulence inhibition by baicalin was investigated using genetic approaches. The impact of baicalin on P. aeruginosa pathogenicity was evaluated by both in vitro assays and in vivo animal models. The results show that baicalin diminished a plenty of important virulence factors in P. aeruginosa, including the Type III secretion system (T3SS). Baicalin treatment reduced the cellular toxicity of P. aeruginosa on the mammalian cells and attenuated in vivo pathogenicity in a Drosophila melanogaster infection model. In a rat pulmonary infection model, baicalin significantly reduced the severity of lung pathology and accelerated lung bacterial clearance. The PqsR of the Pseudomonas quinolone signal (PQS) system was found to be required for baicalin’s impact on T3SS. These findings indicate that baicalin is a promising therapeutic candidate for treating P. aeruginosa infections.
Frequency Domain Analysis of Partial-Tensor Rotating Accelerometer Gravity Gradiometer
Authors: Qian Xuewu , Zhao Liye , Liu Weiming , Sun Jianqiang
Published: March 2021

The output model of a rotating accelerometer gravity gradiometer (RAGG) established by the inertial dynamics method cannot reflect the change of signal frequency, and calibration sensitivity and self-gradient compensation effect for the RAGG is a very important stage in the development process that cannot be omitted. In this study, a model based on the outputs of accelerometers on the disc of RGAA is established to calculate the gravity gradient corresponding to the distance, through the study of the RAGG output influenced by a surrounding mass in the frequency domain. Taking particle, sphere, and cuboid as examples, the input-output models of gravity gradiometer are established based on the center gradient and four accelerometers, respectively. Simulation results show that, if the scale factors of the four accelerometers on the disk are the same, the output signal of the RAGG only contains (4k+2)ω (ω is the spin frequency of disc for RAGG) harmonic components, and its amplitude is related to the orientation of the surrounding mass. Based on the results of numerical simulation of the three models, if the surrounding mass is close to the RAGG, the input-output models of gravity gradiometer are more accurate based on the four accelerometers. Finally, some advantages and disadvantages of cuboid and sphere are compared and some suggestions related to calibration and self-gradient compensation are given.