bluuebunny/crossref_metadata_2025 huggingface dataset:
Resilience Improvement of Microgrid Cluster Systems Based on Two-Stage Robust Optimization
Authors: Ji Shui , Liu Yun , Wu Shanshan , Li Xiao
Published: August 2024

For microgrids in deep and remote sea areas, ocean currents are widely used as an emerging power generation resource. Implementing ES systems is crucial for smooth power output and grid stability. The stability of power output from sea current energy generation faces challenges due to speed fluctuations. Enhancing resilience requires addressing transmission line failures caused by extreme seabed conditions, and ensuring operational security. An ES configuration method considering line faults based on two-stage robust optimization is presented in this paper. First, in order to simultaneously consider planning and operation, a defender–attacker–defender (DAD) model was established. Additionally, the capacity, rated power, and charging/discharging power of ES during operation were jointly optimized through the column-and-constraint generation (C&CG) algorithm. In addition, the rationality and effectiveness of the proposed method were demonstrated through experiments on modified IEEE six-bus and fifty-seven-bus systems. The results show that a distributed ES configuration increased system resilience by 54.60% and reduced abandoned power rate by 57.06% compared with the situation without ES configuration.
Improving Module Temperature Prediction Models for Floating Photovoltaic Systems: Analytical Insights from Operational Data
Authors: Nicola Monica , Berwind Matthew
Published: August 2024

Floating photovoltaic (FPV) systems are gaining popularity as a valuable means of harnessing solar energy on unused water surfaces. However, a significant gap persists in our comprehension of their thermal dynamics and the purported cooling benefits they provide. The lack of comprehensive monitoring data across different climatic regions and topographies aggravates this uncertainty. This paper reviews the applicability of established module temperature prediction models, originally developed for land-based PV systems, to FPVs. It then details the refinement of these models using FPV-specific data and their subsequent validation through large-scale, ongoing FPV projects. The result is a significant improvement in the accuracy of temperature predictions, as evidenced by the reduced Mean Absolute Error (MAE) and improved R-squared (R2) after parameter optimisation. This reduction means that the tailored models better reflect the distinct environmental influences and cooling processes characteristic of FPV systems. The results not only confirm the success of the proposed method in refining the accuracy of current models, but also indicate significant post-tuning changes in the parameters representing wind and convective effects. These adjustments highlight the increased responsiveness of FPVs to convective actions, especially when compared to ground-based systems, possibly due to the evaporative cooling effect of bodies of water. Through this research, we address a critical gap in our understanding of heat transfer in FPV systems and aim to enrich the knowledge surrounding the acknowledged cooling effect of FPVs.
A Master–Slave Game Model of Electric Vehicle Participation in Electricity Markets under Multiple Incentives
Authors: Jiang Linru , Yan Chenjie , Zhang Chaorui , Wang Weiqi , Wang Biyu , Li Taoyong
Published: August 2024

In order to achieve low carbon emissions in the power grid, the impact of new energy grid connections on the power grid should be reduced, as well as the peak-to-valley load difference caused by large-scale electric vehicle grid connections. This paper proposes a two-tier, low-carbon optimal dispatch master–slave game model involving virtual power plant operators as well as electric vehicle operators. Firstly, the carbon flow is tracked based on the proportional sharing principle, and the carbon emission factor during the charging and discharging process of electric vehicles is calculated. Secondly, the node carbon potential and time-sharing tariff are used to guide and change the charging behaviour of electric vehicles and to construct a master–slave game model for low-carbon optimal scheduling with the participation of multiple subjects, with economic scheduling at the upper level of the model and demand response scheduling at the lower level. Finally, the IEEE30 node system is used as an example to verify that the method adopted in this paper can effectively reduce the peak-to-valley difference of loads, reduce the carbon emissions of the grid, and reduce the cost of each participating entity.
A 4E Analysis of a Solar Organic Rankine Cycle Applied to a Paint Shop in the Automotive Industry
Authors: Martire Ronaldo Nilo Miyagi , Erguvan Mustafa , Amini Shahriar
Published: August 2024

In a conventional automotive manufacturing plant, the paint shop alone can represent 36% of the total energy consumption, making it the most demanding area in terms of electricity and fossil fuel energy consumption. This study explores the possibility of decentralizing the production of electrical power and heat simultaneously, using an Organic Rankine Cycle (ORC) system integrated with a Parabolic Trough Collector (PTC) in a paint shop. To date, no similar system has been explored or implemented by the automotive industry. To increase the efficiency of the integrated system, wasted heat generated during the paint manufacturing process is recovered and used to pre-heat the organic fluid in the ORC system. A 4E analysis (Energy, Exergy, Economic, and Environmental) is conducted to determine the practical viability of the proposed system. When applied to the southern region of the USA, this system’s installed capacity is projected to be 11 times higher than the two unique SORC pieces of equipment currently running in Louisiana and Florida. The goals are to reduce the reliance on external primary energy sources and decrease the carbon emission footprint from production activity. The system is evaluated for a location in Alabama, USA. The designed SORC, using toluene, can produce 712.2 kWel net and 13,132 kg/h of hot water, with an overall energy efficiency of 31.02%; exergy efficiency of 34.23; and ORC efficiency of 27.70%. This leads to an electrical energy saving of 5.9% for the manufacturing plant. The regenerative thermal oxidizer (RTO) heat exchanger, the secondary heat source of the system, has the highest exergy destruction—3583 kW. The system avoids the emission of 4521 tCO2 per year. A payback period of 10.16 years for the proposed system is estimated. Considering a planning horizon of 10 years, the investment in the system is also justified by a benefit–cost analysis.
Determination of Local Heat Transfer Coefficients and Friction Factors at Variable Temperature and Velocity Boundary Conditions for Complex Flows
Authors: Hartmann Christopher , von Wolfersdorf Jens
Published: August 2024

Transient conjugate heat transfer measurements under varying temperature and velocity inlet boundary conditions at incompressible flow conditions were performed for flat plate and ribbed channel geometries. Therefrom, local adiabatic wall temperatures and heat transfer coefficients were determined. The data were analyzed using typical heat transfer correlations, e.g., Nu=CRemPrn, determining the local distributions of C and m. It is shown that they are closely linked. A relationship lnC=A−mB is observed, with A and B as modeling parameters. They could be related to parameters in log-law or power-law representations for turbulent boundary layer flows. The parameter m is shown to have a close link to local pressure gradients and, therewith, near wall streamlines as well as friction factor distributions. A normalization of the C parameter allows one to derive a Reynolds analogy factor and, therefrom, local wall shear stresses.
Positive Impact of Late Harvest Date on Polyphenolic Composition of Plavac Mali (Vitis vinifera L.) Wine Depends on Location
Authors: Mucalo Ana , Maletić Edi , Zdunić Goran
Published: August 2024

Asynchronous ripening is a significant challenge in winemaking. Green berries reduce alcohol and pH while increasing acidity. Green berries are rich in bitter and astringent compounds, with an unknown impact on wine quality. The aim of this study was to evaluate the impact of harvest date and vineyard location on the polyphenolic composition of Plavac Mali wines in Dalmatia, Croatia. Experiments were conducted in two locations, Split and Zadar, producing fifteen wines per location from four harvest dates (H1–H4), including green berry wines from H1. The first harvest date occurred 27 days after véraison (DAV) and the last at 69 DAV, corresponding to overripeness. Green berry wines of H1 had low alcohol content up to 4.4% (v/v) in Split. Epigallocatechin was the main flavonoid in those wines, followed by dimer B1 in Split and catechin in Zadar. Green wines from Split had a higher concentration of phenolic acids, flavan-3-ol monomers and dimers. Wines of H3 had the highest concentration of malvidin-3-O-glucoside. With a later harvest date, a dramatic decrease in catechin and dimers was observed in wines from Split, and a decrease in epicatechin, epigallocatechin and dimer B1 in those from Zadar. The final expression of the physiochemical and polyphenolic composition of Plavac Mali wine is determined by the dynamics of harvest date, location and their interactions.
Rice Protein Reduces Triglyceride Levels through Modulating CD36, MTP, FATP, and FABP Expression in Growing and Adult Rats
Authors: Liu Bingxiao , Wang Zhengxuan , Liang Mingcai , Yang Lin
Published: August 2024

To elucidate the effect of rice protein on the regulation of triglyceride transport to reduce triglyceride levels, growing and adult male Wistar rats were fed with casein and rice protein for 2 weeks. With the intake of rice protein, the gene and protein expressions of cluster determinant 36 (CD36), microsomal triglyceride transfer protein (MTP), fatty acid transport protein-2 (FATP-2), and fatty acid-binding protein-1 (FABP-1) were, respectively, downregulated in growing and adult rats, suggesting rice protein could effectively regulate triglyceride transport. As a result, rice protein significantly reduced plasma levels of triglyceride and fatty acids, while hepatic accumulations of triglyceride and fatty acids were also decreased via rice protein. The present study demonstrates that RP exerts regulatory effects on CD36, MTP, FATP-2, and FABP-1 expression in growing and adult rats, revealing a link to triglyceride-lowering actions and the modulations of triglyceride transport exerted by rice protein. Results suggest that the aging process cannot attenuate the depression of CD36, MTP, FATP, and FABP 19 expression to reduce triglyceride levels induced by rice protein.
Advancements in Synthetic Biology for Enhancing Cyanobacterial Capabilities in Sustainable Plastic Production: A Green Horizon Perspective
Authors: Nawaz Taufiq , Gu Liping , Hu Zhong , Fahad Shah , Saud Shah , Zhou Ruanbao
Published: August 2024

This comprehensive review investigates the potential of cyanobacteria, particularly nitrogen-fixing strains, in addressing global challenges pertaining to plastic pollution and carbon emissions. By analyzing the distinctive characteristics of cyanobacteria, including their minimal growth requirements, high photosynthetic efficiency, and rapid growth rates, this study elucidates their crucial role in transforming carbon sequestration, biofuel generation, and biodegradable plastic production. The investigation emphasizes cyanobacteria’s efficiency in photosynthesis, positioning them as optimal candidates for cost-effective bioplastic production with minimized land usage. Furthermore, the study explores their unconventional yet promising utilization in biodiesel production, mitigating environmental concerns such as sulfur emissions and the presence of aromatic hydrocarbons. The resulting biodiesel exhibits significant combustion potential, establishing cyanobacteria as a viable option for sustainable biofuel production. Through a comprehensive assessment of both achievements and challenges encountered during the commercialization process, this review offers valuable insights into the diverse contributions of cyanobacteria. Its objective is to provide guidance to researchers, policymakers, and industries interested in harnessing bio-inspired approaches for structural and sustainable applications, thereby advancing global efforts towards environmentally conscious plastic and biofuel production.
Regulation of Oil Biosynthesis and Genetic Improvement in Plants: Advances and Prospects
Authors: Zhou Lixia , Wu Qiufei , Yang Yaodong , Li Qihong , Li Rui , Ye Jianqiu
Published: August 2024

Triglycerides are the main storage form of oil in plant seeds. Both fatty acids and triglycerides possess important functions in the process of plant growth and development. To improve the seed oil content and improve its fatty acid composition, this paper analyzed the research progress on the oil regulation and synthesis metabolism process of plant seeds and summarized the strategies for the improvement of plant seed oil: (a) To regulate carbon distribution by inhibiting the expression of genes encoding key enzymes, allocating carbon sources into the protein synthesis pathway, and enhancing the expression of key genes encoding key enzymes, leading carbon sources into the synthesis pathway of fatty acids; (b) To intervene in lipid synthesis by promoting the biosynthesis of fatty acids and improving the expression level of key genes encoding enzymes in the triacylglycerol (TAG) assembly process; (c) To improve seed oil quality by altering the plant fatty acid composition and regulating the gene expression of fatty acid desaturase, as well as introducing an exogenous synthesis pathway of long chain polyunsaturated fatty acids; (d) To regulate the expression of transcription factors for lipid synthesis metabolism to increase the seed oil content. In addition, this article reviews the key enzymes involved in the biosynthesis of plant fatty acids, the synthesis of triacylglycerol, and the regulation process. It also summarizes the regulatory roles of transcription factors such as WRI, LEC, and Dof on the key enzymes during the synthesis process. This review holds significant implications for research on the genetic engineering applications in plant seed lipid metabolism.
The Role of the Large T Antigen in the Molecular Pathogenesis of Merkel Cell Carcinoma
Authors: Myrda Julia , Bremm Franziska , Schaft Niels , Dörrie Jan
Published: August 2024

The large T antigen (LT) of the Merkel cell polyomavirus (MCPyV) is crucial for Merkel cell carcinoma (MCC), a rare but very aggressive form of neuroendocrine skin cancer. The clonal integration of MCPyV DNA into the host genome is a signature event of this malignancy. The resulting expression of oncogenes, including the small T (sT) antigen and a truncated form of the LT (truncLT), directly contribute to carcinogenesis. The truncation of the C-terminus of LT prevents the virus from replicating due to the loss of the origin binding domain (OBD) and the helicase domain. This precludes cytopathic effects that would lead to DNA damage and ultimately cell death. At the same time, the LxCxE motif in the N-terminus is retained, allowing truncLT to bind the retinoblastoma protein (pRb), a cellular tumor suppressor. The continuously inactivated pRb promotes cell proliferation and tumor development. truncLT exerts several classical functions of an oncogene: altering the host cell cycle, suppressing innate immune responses to viral DNA, causing immune escape, and shifting metabolism in favor of cancer cells. Given its central role in MCC, the LT is a major target for therapeutic interventions with novel approaches, such as immune checkpoint inhibition, T cell-based immunotherapy, and cancer vaccines.
Effect of Diabetes Education on Complications and Diabetic Control Amongst Adult Patients with Diabetes in Madinah, Saudi Arabia
Authors: Al-Nozha Omar M. , Mogharbel Ghazi H. , Badawi Ahmad S. , Alawfi Abdulaziz K. , Aljayyar Mohammed W. , Makhdoom Osamah N. , Kateb Husain M. , Sayed Anwar A.
Published: August 2024

Background: Diabetes is a chronic condition that may become dangerous if there is insufficient insulin to help the body function properly. The proper care for diabetes depends on how well patients observe guidelines and prescriptions; consequently, patient education is critical. Poor learning may cause bad treatment and complications or other problems related to the disease. Objectives: This study aims to evaluate patients’ knowledge of diabetes, assigning a knowledge (K) score out of 100, and investigate the possible impact of educating patients, through general means or via healthcare professionals, on patient knowledge of diabetes control demonstrated in the absence/presence of diabetic complications. Methods: This multi-center interview-based cross-sectional study used a questionnaire in Madinah, Saudi Arabia. This study was conducted on adults with diabetes who were aged 15–80. We used the Michigan Diabetic Knowledge Test (MDKT) to assess the knowledge of patients with diabetes. Results: This study included 364 participants. The gender distribution was 48.33% male and 51.67% female. Most of them had type 2 diabetes (T2DM) without insulin (48.63%), followed by those with T2DM on insulin (36.26%), and patients with type 1 diabetes (T1DM) (15.11%). Patients with T2DM had significantly higher K scores than patients with type 1. Additionally, T2DM non-insulin patients’ k-scores significantly exceeded those with T1DM. General and healthcare education both helped increase patients’ K-scores. Mostly, patients with diabetes without any complications had significantly higher knowledge compared to those having them. Lastly, regardless of whether the education was delivered by general or professional means, the effect on glycated hemoglobin (HbA1C) levels was not significant. Conclusions: Our study revealed that patients with T2DM exhibited higher knowledge than patients with T1DM. Furthermore, receiving education, whether by a healthcare professional or by general means, improved the knowledge levels of patients with T2DM but not patients with T1DM. Regarding diabetes complications, it was found that those with a higher level of knowledge had fewer complications. However, no evidence receiving education influenced the levels of HbA1C, neither in patients with T1DM nor T2DM.
Prehistoric Recycling Explained in a Playful Way: The Pfahlbauten Wimmelbild—An Interactive Digital Mediation Tool Designed by Young People
Authors: da Fonseca Helena Seidl , Leipold Fiona , Grömer Karina
Published: August 2024

With the “Talents Internship program” established by the Austrian Research Promotion Agency (FFG, Österreichische Forschungsförderungsgesellschaft), 14- to 17-year-old students from various school types visited the Natural History Museum and the Kuratorium Pfahlbauten in summer 2022 to gain practical experience in research. The internship focused on a sustainability approach, discussing recycling methods, the sustainable use of resources and the circular economy in prehistory. The UNESCO World Heritage “Prehistoric Pile Dwellings around the Alps” was used as a research area for the project. The project also aimed to make the content developed by the students available to the public as a digital media tool. The pupils brought an illustration of a prehistoric lake shore settlement to life and created an interactive image available at the website of Kuratorium Pfahlbauten. Various scenes of the illustration have been augmented with animations created by the students of HTL Spengergasse in Vienna. Students from federal secondary schools from Vienna (Stubenbastei) and Upper Austria (Traun) researched the information about the objects and wrote texts that, as a description of the animated videos, introduce the users to the prehistoric artifact and explain the recycling process behind it. The students worked independently using the scientific literature, 140-year-old inventory books and 6000-year-old objects from the collection of the Natural History Museum Vienna. The activities and the supporting program within the internship were recorded by the students in blog posts, available at the Pfahlbauten-Blog. The co-creative approach of the FFG Talent Internship made it possible to introduce a group of school students to the process of scientific work and the communication of results. It was honored with the Creative App Award at CHNT 2023.
Betrayed, Beaten, Banished: The Stigma of Being a Rural Tongqi in China
Authors: Tsang Eileen Y. H. , Yueyao Fang
Published: August 2024

In China, an emerging social issue involves a subset of rural women who, because of family and culture, become inadvertently matched up with and married to closeted men who have sex with men (MSM). These women—referred to as Tongqi—often discover they are in a loveless marriage, but any effort to change their situation results in intense backlash, discrimination, and stigma from families, village communities, and even government and healthcare institutions. This study explores the experiences of Tongqi, examining the influence of social interaction, community relationships, and macrostructural factors that coalesce to create an environment of chronic enacted stigma. In-depth interviews were conducted with 59 rural Tongqi, 11 of whom contracted human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) from their spouses. The findings reveal the significant role of extended kinship networks and macrostructural elements, such as hukou (household registration) and government officers, as well as village-level lineage structures. Informant data highlights how lineage relationships, interwoven with gender practices, contribute to the enacted stigma impacting the physical and psychological health of Tongqi. Tongqi report psychological effects such as an array of symptoms reflecting post-traumatic stress, chronic depression, and attempted suicide. Tongqi also report adverse physical health concerns involving reproductive health, unwanted pregnancies, sexually transmitted infections (STIs), and pregnancy complications. These findings helped produce possible policy recommendations to address the most pressing issues faced by Tongqi.
Factors Associated with Psychological Distress during COVID-19: A Cross-Sectional Study of Sub-Saharan African Migrant Workers across Australia and Canada
Authors: Akombi-Inyang Blessing J. , Byaruhanga Judith , Boamah Sheila A. , Allotey John , Atorkey Prince
Published: August 2024

Objective: Ensuring the sustainability of the migrant workforce requires a comprehensive understanding of the psychological challenges faced by this sub-population due to concerns about the wellbeing and financial situation of family members in their home countries. Therefore, this study investigates the factors associated with psychological distress among sub-Saharan Africa (SSA) migrant workers across Australia and Canada during the COVID-19 pandemic. Method: Data were collected from 378 first-generation migrant workers with SSA ancestry residing in Australia and Canada using the Depression Anxiety and Stress Scale 21 (DASS-21). Multivariate logistic regression analysis was used to determine socio-demographic factors associated with depression, anxiety, and stress among SSA migrants’ populations. Results: Across both countries, migrants with lower levels of education were more prone to reporting feelings of depression, anxiety, and stress during the pandemic. Female participants in Australia were more likely to report feeling of depression. Participants in Australia and Canada who were separated/divorced/widowed were less likely to report stress and depression, respectively. Participants in Australia who had lived in Australia between 11 and 20 years and those between 36 and 50 years old were more likely to report feelings of depression. Participants residing in Australia whose SSA ancestry was Southern Africa/Central Africa were more likely to report anxiety. Participants in Australia who worked as part-time permanent workers and those who worked as fixed-term workers/short-term/casual workers were less likely to report anxiety. Finally, participants in Canada who reported two or more people living with them had higher odds of reporting anxiety. Conclusions: The findings from this study highlight key factors associated with SSA migrant workers’ psychological distress during the pandemic. The results can inform policies and provide insight to the development of mental health intervention strategies for migrant workers to minimize similar distress during pandemics.
Validity of an ICD-10 Coding Algorithm for Acute Heat Illness in the Emergency Department: A Retrospective Cohort Study
Authors: Baassiri Hasan , Varghese Timothy , Clemens Kristin K. , Ouédraogo Alexandra M. , Van Aarsen Kristine , Vujčić Branka , Yan Justin W.
Published: August 2024

Acute heat illness (AHI) from extreme environmental heat exposure can lead to emergency department (ED) visits, hospitalization, and even death. While the ICD ninth revision codes for AHI have been validated in the U.S., there have been no studies on the validity of ICD-10 codes for AHI in Canada. The objective of this study was to assess the validity of an ICD-10 coding algorithm for ED encounters for AHI. We conducted a retrospective cohort study of children and adults who had ED encounters at two large academic, tertiary hospitals in London, Canada, between May and September 2014–2018. We developed an algorithm of ICD-10 codes for AHI based upon a literature review and clinical expertise. Our “gold-standard” definition of AHI was patient-reported heat exposure and documentation of at least one heat-related complaint. To establish positive predictive value (PPV), we reviewed 62 algorithm-positive records and noted which met our “gold-standard” definition. To calculate negative predictive value (NPV), sensitivity (Sn), and specificity (Sp), we randomly reviewed 964 ED records for associated ICD-10 codes and diagnoses. Two independent reviewers completed blinded data abstraction, with duplicate abstraction in 20% of the sample. Of the 62 algorithm-positive records, mean (SD) age was 38.8 (23.8) years; 37% were female. PPV was 61.3 ± 12.1% (95% CI). Of the 964 randomly selected records, mean (SD) age was 41.7 (26.5) years; 51.1% were female. The NPV was 99.7 ± 0.4%, sensitivity 25.0 ± 42.4%, and specificity 100.0 ± 0.0%. An ICD-10 coding algorithm for AHI had high specificity but was limited in sensitivity. This algorithm can be used to assemble and study cohorts of patients who have had an AHI, but may underestimate the true incidence of AHI presentations in the ED.
Application of Pan-Omics Technologies in Research on Important Economic Traits for Ruminants
Authors: Gao Zhendong , Lu Ying , Li Mengfei , Chong Yuqing , Hong Jieyun , Wu Jiao , Wu Dongwang , Xi Dongmei , Deng Weidong
Published: August 2024

The economic significance of ruminants in agriculture underscores the need for advanced research methodologies to enhance their traits. This review aims to elucidate the transformative role of pan-omics technologies in ruminant research, focusing on their application in uncovering the genetic mechanisms underlying complex traits such as growth, reproduction, production performance, and rumen function. Pan-omics analysis not only helps in identifying key genes and their regulatory networks associated with important economic traits but also reveals the impact of environmental factors on trait expression. By integrating genomics, epigenomics, transcriptomics, metabolomics, and microbiomics, pan-omics enables a comprehensive analysis of the interplay between genetics and environmental factors, offering a holistic understanding of trait expression. We explore specific examples of economic traits where these technologies have been pivotal, highlighting key genes and regulatory networks identified through pan-omics approaches. Additionally, we trace the historical evolution of each omics field, detailing their progression from foundational discoveries to high-throughput platforms. This review provides a critical synthesis of recent advancements, offering new insights and practical recommendations for the application of pan-omics in the ruminant industry. The broader implications for modern animal husbandry are discussed, emphasizing the potential for these technologies to drive sustainable improvements in ruminant production systems.
The Effects of Blood Flow Restriction Aerobic Exercise on Body Composition, Muscle Strength, Blood Biomarkers, and Cardiovascular Function: A Narrative Review
Authors: Cho Chaeeun , Lee Sewon
Published: August 2024

Blood flow restriction exercise has emerged as a promising alternative, particularly for elderly individuals and those unable to participate in high-intensity exercise. However, existing research has predominantly focused on blood flow restriction resistance exercise. There remains a notable gap in understanding the comprehensive effects of blood flow restriction aerobic exercise (BFRAE) on body composition, lipid profiles, glycemic metabolism, and cardiovascular function. This review aims to explore the physiological effects induced by chronic BFRAE. Chronic BFRAE has been shown to decrease fat mass, increase muscle mass, and enhance muscular strength, potentially benefiting lipid profiles, glycemic metabolism, and overall function. Thus, the BFRAE offers additional benefits beyond traditional aerobic exercise effects. Notably, the BFRAE approach may be particularly suitable for individuals with low fitness levels, those prone to injury, the elderly, obese individuals, and those with metabolic disorders.
UHPLC-DAD/ESI-TOF-MS Phytochemical Characterization and Evaluation of the Impact of Eleutherococcus senticosus Fruit Intractum on Biochemical, Hepatological, and Blood Parameters in Balb/c Mice
Authors: Graczyk Filip , Gębalski Jakub , Sulejczak Dorota , Małkowska Milena , Wójciak Magdalena , Gawenda-Kempczyńska Dorota , Piskorska Elżbieta , Krolik Krystian , Markiewicz Maciej , Kondrzycka-Dąda Aneta , Lepianka Wiktoria , Borowski Grzegorz , Feldo Marcin , Verporte Robert , Załuski Daniel
Published: August 2024

Eleutherococcus senticosus (Rupr. et Maxim.) Maxim. (ES) has gained popularity for its adaptogenic, immunostimulant, and anti-inflammatory properties. Because of overexploitation of the roots, the species is considered to be endangered and has been put on the Red List in some countries (e.g., the Republic of Korea). Therefore, the fruits of E. senticosus might be explored as a new sustainable source of compounds with adaptogenic activity. This study aimed to assess the chemical composition and the safety profile (hepatotoxicity, blood morphology, biochemical parameters of blood plasma) of E. senticosus fruit intractum in Balb/c mice after oral administration of 750 and 1500 mg/kg b.w. UHPLC analysis coupled with DAD and MS detectors was used to quantify the metabolites. For the first time, oleanolic and ursolic acids were quantified in the intractum (16.01 ± 1.3 and 2.21 ± 0.17 µg/g of oleanolic and ursolic acids, respectively). Regarding polyphenols, chlorogenic acid (0.92 mg/g of dried extract), caffeic acid (0.43 mg/g), dicaffeoylquinic acids (in total: 1.27 mg/g), and an unidentified caffeic acid ester (0.81 mg/g) were identified. The results in Balb/c mice revealed that the intractum does not cause significant variations in red blood cells parameters. In turn, a significant decrease in the total number of leukocytes was observed (5.8 × 103 µL), with a percentage increase in lymphocytes among the groups (80.2, 81.8, and 82.6). The ability of the intractum to decrease alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels may indicate its anti-inflammatory activity. Our observations justify that the fruits of E. senticosus are safe in the doses used and do not cause significant changes in the activity of the liver enzymes or in blood parameters.
A Phenomenon: What Are the Minuscule Grey Moths Abundant in the Dry Season in the Tropical Dry Forests of the Pacific Coast of Honduras?
Authors: Stonis Jonas , Remeikis Andrius , Diškus Arūnas , Dobrynina Viktorija , Orlovskytė Svetlana
Published: August 2024

Our investigation centered on the tropical dry forests along the Pacific coast of Honduras, aiming to elucidate the presence and abundance of minuscule grey moths during the dry season. Through specimen dissections and the taxonomic identification of the collected material, we have described three new species: Acalyptris podenasi sp. nov., A. palpiformis sp. nov., and A. tortoris sp. nov. Additionally, we documented two species previously known from neighboring countries, A. lascuevella Puplesis & Robinson and A. basicornis Remeikis & Stonis. The females of A. lascuevella were previously unknown and are documented here for the first time. Morphological examinations were complemented by DNA barcoding, particularly highlighting variation in A. lascuevella. The paper’s primary significance lies not only in the description of new species but also in uncovering their taxonomic, morphological, and molecular importance. We found that these species are unique and indicative of the previously unstudied dry forests as a distinct ecosystem. Our findings revealed several novel atypical morphological traits within the studied Nepticulidae, including unusually large signum cells in the female genitalia, a dorso-ventrally divided uncus, and asymmetrical valvae in the male genitalia. These discoveries underscore the morphological diversity of Acalyptris Meyrick and their significance in evolutionary biology. Consequently, the paper addresses a previously unknown phenomenon of the occurrence and astonishing abundance of minuscule plant-mining micromoths in dry deciduous forests during the peak of the dry season. We hope that this paper will encourage Lepidoptera taxonomists to explore micromoths in other tropical dry forests, which, while limited in distribution, hold global importance. The paper is extensively illustrated with photographs of Acalyptris adults and their genitalia, along with maps, habitats, and molecular phylogenetic trees.
BmToll9-1 Is a Positive Regulator of the Immune Response in the Silkworm Bombyx mori
Authors: Liu Jisheng , Chen Weijian , Situ Jinrong , Li Jiaxuan , Chen Jiahua , Lai Minchun , Huang Fengyi , Li Baoqi
Published: August 2024

Toll receptors are involved in the development and innate immunity of insects. BmToll9-1 is an important immune receptor in the Toll pathway. Previous studies have focused on its role as a receptor in immune response. In this study, we aimed to investigate the role of BmToll9-1 as a regulator in the immune response. The expression profiles demonstrated that BmToll9-1 was predominantly expressed in the midgut. RNA interference (RNAi) of BmToll9-1 was found to be effective in the midgut via the injection of dsRNA, which resulted in smaller and lighter larvae and cocoons. Most signaling genes in the Toll pathway and downstream effector genes were downregulated after the RNAi of BmToll9-1. The hemolymph from BmToll9-1-silenced larvae showed decreased antibacterial activity against Escherichia coli, either in growth curve or inhibition zone experiments. The above results indicate that BmToll9-1 might be positively involved in the immune pathway of silkworm. As a positive regulator, BmToll9-1 might function mainly in the gut to maintain microbial homeostasis to regulate the growth of silkworms. Silencing of BmToll9-1 downregulates the signaling genes in the Toll pathway and antimicrobial peptide (AMP) production, resulting in decreased antibacterial activity in the hemolymph.
Parametric Optimization of Entropy Generation in Hybrid Nanofluid in Contracting/Expanding Channel by Means of Analysis of Variance and Response Surface Methodology
Authors: Zeeshan Ahmad , Ellahi Rahmat , Rafique Muhammad Anas , Sait Sadiq M. , Shehzad Nasir
Published: August 2024

This study aims to propose a central composite design (CCD) combined with response surface methodology (RSM) to create a statistical experimental design. A new parametric optimization of entropy generation is presented. The flow behavior of magnetohydrodynamic hybrid nanofluid (HNF) flow through two flat contracting expanding plates of channel alongside radiative heat transmission was considered. The lower fixed plate was externally heated whereas the upper porous plate was cooled by injecting a coolant fluid with a uniform velocity inside the channel. The resulting equations were solved by the Homotopic Analysis Method using MATHEMATICA 10 and Minitab 17.1. The design consists of several input factors, namely a magnetic field parameter (M), radiation parameter (N) and group parameter (Br/A1). To obtain the values of flow response parameters, numerical experiments were used. Variables, especially the entropy generation (Ne), were considered for each combination of design. The resulting RSM empirical model obtained a high coefficient of determination, reaching 99.97% for the entropy generation number (Ne). These values show an excellent fit of the model to the data.
A Study on the Impact of Different PV Model Parameters and Various DC Faults on the Characteristics and Performance of the Photovoltaic Arrays
Authors: Baradieh Khaled Ibrahim , Zainuri Muhammad Ammirrul Atiqi Mohd , Mohamed Kamari Nor Azwan , Abdullah Huda , Yusof Yushaizad , Zulkifley Mohd Asyraf , Koondhar Mohsin Ali
Published: August 2024

PV systems play a vital role in the global renewable energy sector, and they require accurate modeling and reliable performance to maximize the output power. This research presents a thorough analysis and discussions on the effects of different PV models’ parameters and certain specific faults on the performance and behavior of the photovoltaic systems under different temperature and irradiation conditions. It provides a detailed analysis of how several parameters affect the performance of the PV arrays, for instance, the series resistance, shunt resistance, photocurrent, reverse saturation current, and the diode ideality factor. These parameters were extracted mathematically and verified with the help of wide-ranging simulations and practical experiments. Additionally, the investigation of the effect of DC faults, including line-to-line, line-to-ground, partial shading, and complete shading faults on PV arrays, provides important fundamentals for fault detection and classification, thus improving the efficiency and protection of PV systems. It can, therefore, be stated that the outcomes of this research will assist in the enhancement of PV systems in terms of design, operation, and maintainability of photovoltaic plants, as well as contribute positively to the advancement of sustainable solar energy technology.
Self-Cooling Textiles—Substrate Independent Energy-Free Method Using Radiative Cooling Technology
Authors: Zimmermann Lea , Stegmaier Thomas , Kaya Cigdem , Gresser Götz T.
Published: August 2024

Due to climate change, population increase, and the urban heat island effect (UHI), the demand for cooling energy, especially in urban areas, has increased and will further increase in the future. Technologies such as radiative cooling offer a sustainable and energy-free solution by using the wavelength ranges of the atmosphere that are transparent to electromagnetic radiation, the so-called atmospheric window (8–13 µm), to emit thermal radiation into the colder (3 K) outer space. Previous publications in the field of textile building cooling have focused on specific fiber structures and textile substrate materials as well as complex multi-layer constructions, which restrict the use for highly scaled outdoor applications. This paper describes the development of a novel substrate-independent coating with spectrally selective radiative properties. By adapting the coating parameters and combining low-emitting and solar-reflective particles, along with a matrix material emitting strongly in the mid-infrared range (MIR), substrate-independent cooling below ambient temperature is achieved. Moreover, the coating is designed to be easily applicable, with a low thickness, to ensure high flexibility and scalability, making it suitable for various applications such as membrane architecture, textile roofs, or tent construction. The results show a median daytime temperature reduction (7 a.m.–7 p.m.) of 2 °C below ambient temperature on a hot summer day.
Bone Quality Indices Correlate with Growth Hormone Secretory Capacity in Women Affected by Weight Excess: A Cross-Sectional Study
Authors: Gangitano Elena , Curreli Maria Ignazia , Gandini Orietta , Masi Davide , Spoltore Maria Elena , Gnessi Lucio , Lubrano Carla
Published: August 2024

Background/Objectives: Obesity can be associated with impaired growth hormone (GH) secretion, with possible negative repercussions on bone health. We aimed to investigate the relationships between GH secretory capacity, evaluated with GHRH + arginine stimulation test, and bone parameters, assessed with a dual-energy X-ray absorptiometer, in a population of adult female patients affected by overweight and obesity. Methods: We assessed 276 women affected by overweight or obesity referred to the High-Specialization Center for the Care of Obesity, Umberto I Polyclinic, between 2014 and 2019 with signs or symptoms of growth hormone deficiency (GHD). Results: A total of 97 patients were diagnosed with GHD, and 179 patients with normal GH secretion were considered our control group. GHD patients showed a significantly reduced trabecular bone score (TBS) (p = 0.01). Bone quality parameters corrected for body mass index (BMI) had a positive and significant linear correlation with stimulated GH secretory capacity. Conclusions: In conclusion, bone quality, evaluated by TBS and hip structural analysis, correlates with GH-stimulated secretory capacity. GHD may act as an additive factor in the alteration of bone microarchitecture in patients affected by obesity, who are already at a higher risk of fractures.
Glenolabral Articular Disruption (GLAD) Is Not Associated with Worse Outcomes or Higher Instability Recurrence after Arthroscopic Bankart Repair—A Matched-Pair Analysis
Authors: Vieider Romed P. , Siebenlist Sebastian , Sanchez Jose C. , Heil Selina , Wackerle Anja , Fritsch Lorenz , Scheiderer Bastian , Hinz Maximilian , Lacheta Lucca
Published: August 2024

Background: This study aimed to compare clinical outcomes and recurrence of instability after arthroscopic Bankart repair (ABR) in patients with anterior shoulder instability, with and without a GLAD lesion, while distinguishing between primary and recurrent instability. Methods: Consecutive patients who underwent isolated ABR between January 2012 and December 2021 were included. Patients with a concomitant GLAD lesion were matched in with patients without a GLAD lesion according to the following criteria: age, sex, BMI, follow-up time, and primary versus recurrent instability. At minimum two-year follow-up, the clinical outcome (Rowe score, redislocation rate) and the functional outcome, including the American Shoulder and Elbow Surgeons (ASES) score, Western Ontario Shoulder Instability Index (WOSI), Oxford Shoulder Instability Score (OSIS), satisfaction (1–10 scale, 0 = unsatisfied, 10 = very satisfied), and Visual Analogue Scale (VAS), were compared between groups. Results: In total, 28 patients (14 GLAD vs. 14 Bankart; age: 32.5 ± 13.0 years; sex: 92.9% male; BMI: 24.6 ± 2.2) were included 6.9 ± 2.8 (2–11) years after isolated ABR (follow-up rate 63.6%). Clinical and functional outcome did not differ significantly between patients with versus without GLAD lesions (ASES score: 100 [96.5–100] vs. 97.5 [93.3–100], p = 0.27); WOSI (%): 9.0 [3.7–24.5] vs. 3.8 [0.8–8.9], p = 0.22; Rowe score: 90.0 [75.0–100] vs. 95.0 [78.8–100], p = 0.57; OSIS: 46 [44.7–48] vs. 46 [43.0–48], p = 0.54; satisfaction: 8.9 ± 1.4 vs. 8.0 ± 1.4, p = 0.78; VAS 0 [0–1.3] vs. 0 [0–1.0]. In both groups, two patients (14.3%) reported a redislocation during the observation period. Conclusions: At short- to mid-term follow-up, ABR showed favorable outcomes, low dislocation rates, and high patient satisfaction, regardless of the presence of a GLAD lesion or primary versus recurrent instability. However, follow-up time was heterogeneous, and the follow-up rate was marginal.
Optimal Timing of Angiography-Guided Complete Revascularization of Non-Culprit Lesions in STEMI Patients with Multivessel Disease
Authors: Sucato Vincenzo , Madaudo Cristina , Marotta Antonia , Ortello Antonella , Camarda Emmanuele Antonio , Comparato Francesco , Galassi Alfredo Ruggero
Published: August 2024

Background: There are many questions regarding the optimal approach to treating non-culprit lesions in STEMI patients. Several questions still need to be answered, such as identifying the lesions to be revascularized and the optimal timing. Methods: We conducted a single-center analysis. The primary outcome was the incidence of major cardiovascular and cerebral adverse events (MACCE) at 12 months in patients with STEMI and multivessel disease (MVD) who achieved complete revascularization during the index procedure or with a staged procedure. The secondary outcomes were death from any cause, myocardial infarction, target lesion revascularization, stroke, major bleeding events, new angina episodes, new hospitalization, and in-hospital MACCE. Results: From January 2021 to December 2022, a total of 230 patients with STEMI underwent primary PCI in our department; 87 patients had MVD. Fifty-nine patients (67.8%) underwent a non-culprit revascularization strategy during the index procedure strategy, and 28 patients (32.2%) during a staged procedure. The incidence of MACCE at 12 months was 11.9% (seven patients) in the index PCI group, compared with 32.1% (nine patients) in the staged PCI group (odds ratio, 3.52; 95% CI, 1.15 to 10.77; p = 0.022). In-hospital MACCE occurred in five patients (8.5%) of the index PCI group, compared with seven patients (25%) in the staged PCI group (odds ratio, 3.60; 95% CI, 1.03 to 12.61; p = 0.036). A trend towards better outcomes favoring the index PCI group was observed with death from any cause, myocardial infarction, target lesion revascularization, and new angina episodes. Conclusions: Better outcomes were evident with an index PCI strategy than with a staged PCI strategy for complete revascularization in patients with STEMI and MVD.