bluuebunny/crossref_metadata_2025 huggingface dataset:
Feeding of Atlantic bluefin tuna Thunnus thynnus around the Canary Islands assessed from stomach content and stable isotope analyses
Authors: Varela JL , Medina A , Déniz S , Abascal FJ
Published: February 2022

The Canary archipelago, which is part of the Atlantic biogeographical region of Macaronesia, provides suitable habitat for tropical and temperate-water large pelagic species. Atlantic bluefin tuna (ABFT) Thunnus thynnus occur year round in the Canary Islands. Life history traits of ABFT, specifically foraging patterns, have not been studied thus far in this region. We investigated ABFT trophic biology, combining stomach content and stable isotope analyses. A high proportion (~77%) of the stomachs contained prey, indicating active foraging. The diet primarily consisted of fishes, among which the snipefish Macroramphosus sp. was the major prey. Cephalopods and crustaceans were less important diet components. Moreover, a well-preserved specimen of Cory’s shearwater Calonectris borealis was found in a stomach sampled in 2018. Besides natural prey, 16.7% of the stomachs contained plastic debris. Inter-annual isotopic differences were detected in liver tissue samples, reflecting a dietary shift in 2018, where δ15N values were lower than in 2016 and 2017. Isotopic niche width estimations from stable isotope Bayesian ellipse in R and kernel utilization density analyses suggested a more diverse diet in 2017. Corrected and Bayesian standard ellipse area values from muscle and liver data indicated that the diet of ABFT in the Canary Islands is more euryphagous than in the Strait of Gibraltar (East Atlantic) but more stenophagous than it is in the Gulf of Saint Lawrence (West Atlantic). The present results show that the Canary archipelago represents a foraging ground for ABFT in spring.
Pushing the Boundaries of Your PhD: Exploring Careers Outside the Ivory Tower
Authors: Gilbert Danielle , Gubitz S. R. , Kavanagh Jennifer , Piazza Kelly
Published: February 2022

This chapter highlights the diversity of career options open to Political Science PhDs, in particular those outside of tenure track jobs at major research universities and small liberal arts colleges. The chapter describes the advantages, disadvantages, and how to prepare for teaching opportunities at the U.S. military service academies and professional military education institutions; pre-collegiate education positions; policy-focused jobs at think tanks, nonprofits, and in government; and private sector jobs. NOTE: This manuscript is part of Strategies for Navigating Graduate School and Beyond, a forthcoming volume for those interested in pursuing graduate education in political science (Fall 2022 publication).
Analysis of m6A Methylation Modification Patterns and Tumor Immune Microenvironment in Breast Cancer
Authors: Dong Menglu , Shen Wenzhuang , Yang Guang , Yang Zhifang , Li Xingrui
Published: February 2022

Increasing evidence indicates that the abnormal expression of N6-methyladenosine (m6A) modification is closely related to the epigenetic regulation of immune response in breast cancer (BC). However, the potential roles of m6A modification in the tumor microenvironment (TME) of BC remain unclear. For addressing this issue, we comprehensively analyzed the m6A modification patterns in 983 samples and correlated these modification patterns with TME immune cell infiltration, based on 23 kinds of m6A regulators. Principal component analysis (PCA) was used to construct the m6A scoring system to quantify the modification pattern of m6A of BC individuals. Consequently, three different m6A modification patterns were identified, and the infiltrating characteristics of TME cells were consistent with the three immune phenotypes, including immune rejection, immune inflammation, and immune desert. Besides, our analysis showed that the prognosis of patients could be predicted by evaluating the m6A modification pattern in the tumor. The low m6Ascore corresponded to increased mutation burden and immune activation, while stroma activation and lack of immune infiltration were observed in high m6Ascore subtypes. In addition, a low m6Ascore was associated with enhanced response to anti-PD-1/PD-L1 immunotherapy. In conclusion, the m6A modification pattern was closely related to the BC immune landscape. This well-validated score model of the m6A modification patterns will provide a valuable tool to depict the tumor immune state and guide effective tumor immunotherapy for combating BC.
A Proteomic Platform Enables to Test for AML Normalization In Vitro
Authors: Meier-Menches Samuel M. , Neuditschko Benjamin , Janker Lukas , Gerner Marlene C. , Schmetterer Klaus G. , Reichle Albrecht , Gerner Christopher
Published: February 2022

Acute promyelocytic leukaemia (APL) can be cured by the co-administration of arsenic trioxide (ATO) and all-trans retinoic acid (ATRA). These small molecules relieve the differentiation blockade of the transformed promyelocytes and trigger their maturation into functional neutrophils, which are physiologically primed for apoptosis. This normalization therapy represents a compelling alternative to cytotoxic anticancer chemotherapy, but lacks an in vitro model system for testing the efficiency of novel combination treatments consisting of inducers of differentiation and metallopharmaceuticals. Here, using proteome profiling we present an experimental framework that enables characterising the differentiation– and metal-specific effects of the combination treatment in a panel of acute myeloid leukaemia (AML) cell lines (HL-60 and U937), including APL (NB4). Differentiation had a substantial impact on the proteome on the order of 10% of the identified proteins and featured classical markers and transcription factors of myeloid differentiation. Additionally, ATO provoked specific cytoprotective effects in the AML cell lines HL-60 and U937. In HL-60, these effects included an integrated stress response (ISR) in conjunction with redox defence, while proteasomal responses and a metabolic rewiring were observed in U937 cells. In contrast, the APL cell line NB4 did not display such adaptions indicating a lack of plasticity to cope with the metal-induced stress, which may explain the clinical success of this combination treatment. Based on the induction of these cytoprotective effects, we proposed a novel metal-based compound to be used for the combination treatment instead of ATO. The organoruthenium drug candidate plecstatin-1 was previously shown to induce reactive oxygen species and an ISR. Indeed, the plecstatin-1 combination was found to affect similar pathways compared to the ATO combination in HL-60 cells and did not lead to cytoprotective response signatures in NB4. Moreover, the monocytic cell line U937 showed a low plasticity to cope with the plecstatin-1 combination, which suggests that this combination might achieve therapeutic benefit beyond APL. We propose that the cytoprotective plasticity of cancer cells might serve as a general proxy to discover novel combination treatments in vitro.
Regulation of the Interfaces Between Argyrodite Solid Electrolytes and Lithium Metal Anode
Authors: Pang Bo , Gan Yongping , Xia Yang , Huang Hui , He Xinping , Zhang Wenkui
Published: February 2022

Lithium-ion batteries (LIBs) are widely used in portable electronic devices, electric vehicles and large scale energy storage, due to their considerable energy density, low cost and long cycle life. However, traditional liquid batteries suffer from safety problems such as leakage, thermal runaway and even explosion. Part of the issues are caused by lithium dendrites puncturing the liquid electrolyte during cycling. In order to achieve the objective of higher safety and energy density, a rigid solid-state electrolyte (SSE) is proposed instead of liquid electrolyte (LE). Thereinto, sulfide SSEs have received of the most attention due to their high ionic conductivity. Among all the sulfide SSEs, argyrodite SSEs are considered to be one of the most promising solid-state electrolytes due to their high ionic conductivity, high thermal stability and good processablity. On the other hand, lithium metal is an ideal material for anode because of its high specific energy, low potential and large storage capacity. However, interfacial problems between argyrodite SSEs and the anode (interfacial reactions, lithium dendrites, etc.) are considered to be important factors affecting their availability. In this mini review, we summarize the behavior, properties and problems arising at the interface between argyrodite SSEs and anode. Strategies to solve interface problems and stabilize interfaces in recent years are also discussed. Finally, a brief outlook about argyrodite SSEs is presented.
The Metaphor of War in Political Discourse on COVID-19 in Uganda
Authors: Atuhura Dorothy
Published: February 2022

The article examines the use of the metaphor of war in political communication on the novel COVID-19 pandemic in Uganda using two analytical tools of the social representation theory, anchoring and objectification. Drawing data for analysis from six widely televised presidential addresses to the nation on COVID-19 made by Uganda’s president, H.E. Yoweri Kaguta Museveni during the months of March 2020 to September 2020, the article argues that during the time of the COVID-19 pandemic, there was a persistent dominant use of the metaphor of war by government representatives as a rhetorical device to communicate about and to make intelligible an emerging unknown virus as a threat that should be managed through combat behavior. In so doing, the use of the war metaphor and its implied call for combat behavior to control, manage, and eradicate the virus spread engendered consequences such as standardizing hegemonic understanding of the nature and causes of the virus as well as normalizing and legitimizing interventions that the government adopted to manage it.
The Effect of Intraoperative Cerebral Oximetry Monitoring on Postoperative Cognitive Dysfunction and ICU Stay in Adult Patients Undergoing Cardiac Surgery: An Updated Systematic Review and Meta-Analysis
Authors: Tian Li-Juan , Yuan Su , Zhou Cheng-Hui , Yan Fu-Xia
Published: February 2022

Aim

Determining whether intraoperative cerebral oximetry monitoring-guided intervention reduces the risk of postoperative cognitive dysfunction remains controversial. The objective of this study was to conduct an up-to-date meta-analysis to comprehensively assess the effects of regional cerebral oxygen saturation (rSO2) monitoring-guided intervention on cognitive outcomes after cardiac surgery.

Methods

PubMed, EMBASE, Ovid, and Cochrane Library databases were systematically searched using the related keywords for cardiac surgical randomized-controlled trials (RCTs) published from their inception to July 31, 2021. The primary outcome was postoperative delirium (POD). The secondary outcomes were postoperative cognitive decline (POCD) and other major postoperative outcomes. The odds ratio (OR) or weighted mean differences (WMDs) with 95% confidence interval (CI) were used to pool the data. The random-effect model was used for the potential clinical inconsistency. We performed meta-regression and subgroup analyses to assess the possible influence of rSO2 monitoring-guided intervention on clinical outcomes.

Results

In total, 12 RCTs with 1,868 cardiac surgical patients were included. Compared with controls, the incidences of POD (n = 6 trials; OR, 0.28; 95% CI, 0.09–0.84; p = 0.02; I2 = 81%) and POCD (n = 5 trials; OR, 0.38; 95% CI, 0.16–0.93; p = 0.03; I2 = 78%) were significantly lower in the intervention group. Cerebral oximetry desaturation also showed a positive association with the incidence of POD (n = 5 trials; OR, 2.02; 95% CI, 1.25–3.24; p = 0.004; I2 = 81%). The duration of intensive care unit (ICU) stay was markedly shorter in the intervention group than in the control group (n = 10 trials; WMD, −0.22 days; 95% CI, −0.44 to −0.00; p = 0.05; I2 = 74%). Univariate meta-regression analyses showed that the major sources of heterogeneity were age (p = 0.03), body mass index (BMI, p = 0.05), and the proportion of congenital heart disease (CHD, p = 0.02) for POD, age (p = 0.04) for POCD, diabetes mellitus (DM, p = 0.07), cerebrovascular accident (CVA, p = 0.02), and chronic obstructive pulmonary disease (COPD, p = 0.09) for ICU stay. Subsequent subgroup analyses also confirmed these results.

Conclusion

Available evidence from the present study suggests that an intraoperative cerebral oximetry desaturation is associated with an increased POD risk, and the rSO2 monitoring-guided intervention is correlated with a lower risk of POD and POCD, and a shorter ICU stay in adults undergoing cardiac surgery. These clinical benefits may be limited in patients with older age, diabetes status, high BMI, non-CHD, non-COPD, or a previous cardiovascular accident.

Systematic Review Registration: [PROSPREO], identifier: [CRD42021252654].
Tidal Modulation of Hydrothermal Tremor: Examples From Ischia and Campi Flegrei Volcanoes, Italy
Authors: Petrosino Simona , Dumont Stéphanie
Published: February 2022

Volcano dynamics results from an interplay between internal and external processes spanning different time scales. Unravelling how such processes interact may provide key insights into the mechanisms that may lead to the destabilization of the volcanoes and eruption, a critical information to forecast hazards. Studies dealing with tidal influence on volcanoes fall within this context, yet the cause-effect relationship between tides and eruptions is still poorly understood. In the present study, we investigate the tidal influence on two nearby volcanoes, Ischia and Campi Flegrei (Italy), characterized by intense hydrothermal activity. We analyze the seismic tremor of hydrothermal origin recorded by four seismic stations between January and June 2020 by using Singular Spectrum Analysis. We detect up to five long term tidal periodicities ranging from ∼5 to ∼29 days. The results indicate that the seismic tremor is modulated by Earth tides at both volcanoes. In addition, differences in phase and amplitude modulation between the response of both hydrothermal systems to tidal forcing reveal specific features related to the tremor source and to properties of the surrounding medium. These phenomena indicate an interplay between solid Earth and the dynamics of these two volcanoes. Similar approaches on hydrothermal systems at volcanoes would contribute to better characterize the hydrothermal circulation and their evolving conditions that may represent a precursor of a new phase of activity.
The Characteristics of Organic Carbon in the Offshore Sediments Surrounding the Leizhou Peninsula, China
Authors: Xia Jia , Han Yongqiang , Tan Jingqian , Abarike Grace Awinmalsim , Song Zhiguang
Published: February 2022

A total of 43 seafloor surface sediment samples collected from the offshore region surrounding the Leizhou Peninsula were analyzed in terms of the total organic carbon content (TOC), total nitrogen (TN), organic carbon isotope (δ13Corg) and sediment grain size. Our results showed that the organic carbon content in the samples ranged from 0.12 to 0.79%, with an average of 0.42% which was lower compared with other offshore regions of China, whereas the δ13Corg was in the range of −22.47‰ to −19.18‰. The total nitrogen content ranged from 0.011 to 0.100% which was also low. The combination of δ13Corg and TOC/TN ratio (5.1–14.3) suggested that the organic matter is dominant by marine authigenic source input, as marine sourced organic matter accounts for 71%, 82%, and 75% in the sediments from the offshore areas of the east side, west side and the south (Qiongzhou Strait) of the Leizhou Peninsula, respectively. The weak/poor correlations between the organic carbon and clay, silt content, the pH and Eh value suggested that organic matter abundance and distribution were influenced by the source input of organic matter, the seafloor sediments’ redox status, and seawater’s hydrodynamic condition.
Scientific Controversies and Epistemological Sensitization - Effects of an Intervention on Psychology Students’ Epistemological Beliefs and Argumentation Skills
Authors: Klopp Eric , Stark Robin
Published: February 2022

The present study investigates the effects of an intervention presenting resolvable, scientific controversies and an epistemological sensitization measure on the changes in psychology students’ epistemological beliefs. Drawing on the notion that the presentation of resolvable scientific controversies induces epistemological doubt and the notion that inducing epistemological doubt is eased in the presence of an epistemological sensitization, we used an epistemological beliefs intervention consisting of five resolvable controversies that were applied in a sample consisting of psychology students. We hypothesized that the intervention would reduce absolutist and multiplist epistemological beliefs while, at the same time, increasing evaluativist beliefs. We also assumed that the epistemological sensitization would enhance the effect of the intervention. For a domain-specific questionnaire, the results indicated a reduction of absolutist epistemological beliefs regardless of the presence of the epistemological sensitization. Unexpectedly, there was a backfire effect indicated by a rise of multiplist beliefs. For a domain- and topic-specific questionnaire, there was no significant reduction of absolutist and multiplist beliefs but a significant increase in evaluativist beliefs when the epistemological sensitization was present. A measure assessing argumentation skills revealed an increase in argumentation skills only when the epistemological sensitization is present. Finally, we discuss limitations, educational implications, and directions for future research.
An Incentive Strategy of Shiftable Load Participation in Demand Response Based on User Electricity Preference
Authors: Li Wei , Han Ruidi , Zhang Jie , Sun Chenjia , Fu Peng
Published: February 2022

China has promoted the development of the new energy power generation industry since 2013. However, the high proportion of unique energy access to the grid brings greater volatility and uncertainty. One effective way to solve these problems is incentivizing shiftable loads (SLs) to demand response (DR). The low enthusiasm of SLs lies in the lack of an effective incentive mechanism and strategy. Because the SLs’ initiatives participating in the DR are closely related to its structure of comfort and economic preference, we divided SLs into economical users (EUs), standard users (SUs), and comfortable users (CUs). Considering the balance of the benefits between the load aggregator (LA) and SLs and the impact of resource scarcity, we build the optimal incentive model based on the principal-agent theory under the case of symmetry and asymmetry information. Based on MATLAB simulation, we have the following suggestions for LA: 1) In terms of dispatch sequence, LA should dispatch SUs first and then EUs and CUs, 2) In the setting of retained earnings, EUs should be the most, followed by SUs, and the least is CUs, 3) In terms of incentive intensity, CUs need the most incentive, EUs need moderate, and SUs need the least, 4) LAs need to adjust the intensity of incentive contracts according to the scarcity of resources, 5) LAs should also improve their service to reduce users’ risk aversion to strengthen their effort level.
Pharmacological Inhibition of FAK-Pyk2 Pathway Protects Against Organ Damage and Prolongs the Survival of Septic Mice
Authors: Alves Gustavo Ferreira , Aimaretti Eleonora , Einaudi Giacomo , Mastrocola Raffaella , de Oliveira Junior Garcia , Collotta Debora , Porchietto Elisa , Aragno Manuela , Cifani Carlo , Sordi Regina , Thiemermann Christoph , Fernandes Daniel , Collino Massimo
Published: February 2022

Sepsis and septic shock are associated with high mortality and are considered one of the major public health concerns. The onset of sepsis is known as a hyper-inflammatory state that contributes to organ failure and mortality. Recent findings suggest a potential role of two non-receptor protein tyrosine kinases, namely Focal adhesion kinase (FAK) and Proline-rich tyrosine kinase 2 (Pyk2), in the inflammation associated with endometriosis, cancer, atherosclerosis and asthma. Here we investigate the role of FAK-Pyk2 in the pathogenesis of sepsis and the potential beneficial effects of the pharmacological modulation of this pathway by administering the potent reversible dual inhibitor of FAK and Pyk2, PF562271 (PF271) in a murine model of cecal ligation and puncture (CLP)-induced sepsis. Five-month-old male C57BL/6 mice underwent CLP or Sham surgery and one hour after the surgical procedure, mice were randomly assigned to receive PF271 (25 mg/kg, s.c.) or vehicle. Twenty-four hours after surgery, organs and plasma were collected for analyses. In another group of mice, survival rate was assessed every 12 h over the subsequent 5 days. Experimental sepsis led to a systemic cytokine storm resulting in the formation of excessive amounts of both pro-inflammatory cytokines (TNF-α, IL-1β, IL-17 and IL-6) and the anti-inflammatory cytokine IL-10. The systemic inflammatory response was accompanied by high plasma levels of ALT, AST (liver injury), creatinine, (renal dysfunction) and lactate, as well as a high, clinical severity score. All parameters were attenuated following PF271 administration. Experimental sepsis induced an overactivation of FAK and Pyk2 in liver and kidney, which was associated to p38 MAPK activation, leading to increased expression/activation of several pro-inflammatory markers, including the NLRP3 inflammasome complex, the adhesion molecules ICAM-1, VCAM-1 and E-selectin and the enzyme NOS-2 and myeloperoxidase. Treatment with PF271 inhibited FAK-Pyk2 activation, thus blunting the inflammatory abnormalities orchestrated by sepsis. Finally, PF271 significantly prolonged the survival of mice subjected to CLP-sepsis. Taken together, our data show for the first time that the FAK-Pyk2 pathway contributes to sepsis-induced inflammation and organ injury/dysfunction and that the pharmacological modulation of this pathway may represents a new strategy for the treatment of sepsis.
Microstructure and Genetic Polymorphisms: Role in Motor Rehabilitation After Subcortical Stroke
Authors: Liu Jingchun , Wang Caihong
Published: February 2022

Background and Purpose: Motor deficits are the most common disability after stroke, and early prediction of motor outcomes is critical for guiding the choice of early interventions. Two main factors that may impact the response to rehabilitation are variations in the microstructure of the affected corticospinal tract (CST) and genetic polymorphisms in brain-derived neurotrophic factor (BDNF). The purpose of this article was to review the role of these factors in stroke recovery, which will be useful for constructing a predictive model of rehabilitation outcomes.

Summary of Review: We review the microstructure of the CST, including its origins in the primary motor area (M1), primary sensory area (S1), premotor cortex (PMC), and supplementary motor area (SMA). Damage to these fibers is disease-causing and can directly affect rehabilitation after subcortical stroke. BDNF polymorphisms are not disease-causing but can indirectly affect neuroplasticity and thus motor recovery. Both factors are known to be correlated with motor recovery. Further work is needed using large longitudinal patient samples and animal experiments to better establish the role of these two factors in stroke rehabilitation.

Conclusions: Microstructure and genetic polymorphisms should be considered possible predictors or covariates in studies investigating motor recovery after subcortical stroke. Future predictive models of stroke recovery will likely include a combination of structural and genetic factors to allow precise individualization of stroke rehabilitation strategies.
Drug-Coated Balloon-Oriented Angioplasty for Severe Symptomatic Atherosclerotic MCA Stenosis in Young Adults
Authors: Zhang Yuyan , Chu Xi , Meng Yao , Zhang Jun , Sun Lili , Zhao Wei , Zheng Meimei , Yin Hao , Wang Wei , Zhang Jinping , Song Yun , Han Ju
Published: February 2022

Purpose

The clinical significance of endovascular therapy in young patients with symptomatic intracranial atherosclerotic stenosis is not clear. We aimed to report our preliminary findings on the safety and effectiveness of a new endovascular treatment strategy, drug-coated balloon (DCB)-oriented angioplasty for young adults with severe symptomatic atherosclerotic middle cerebral artery (MCA) stenosis.

Methods

We retrospectively retrieved the data of seven young patients aged 21–32 years old with severe symptomatic atherosclerotic MCA stenosis treated with DCB-oriented angioplasty from January 2018 to October 2020. We collected clinical presentations, perioperative complications, and clinical and radiological outcomes.

Results

The DCB was successfully dilated at the lesions in all seven patients and good antegrade perfusion was achieved in five. The other two patients underwent remedial stent implantation due to residual stenosis >50% and unstable antegrade perfusion after DCB dilatation. However, none of the patients had perioperative complications. There were no recurrent ischemic symptoms after a mean clinical follow-up period of 15.4 ± 6.9 months. Repeat vascular images of the patients showed no restenosis at 3- or 6-month imaging follow-up periods. High-resolution MRI (HRMRI) was completed in all the patients before the angioplasty procedure and at follow-up. Focal eccentric wall thickening was present at the site of stenosis preoperatively; however, the plaques had disappeared by the time of follow-up for all patients.

Conclusion

DCB-oriented angioplasty may be safe and effective for young patients with severe symptomatic atherosclerotic MCA stenosis.
Imaging Lymphoma With F-18 Fluorodeoxyglucose PET-CT: What Should Be Known About Normal Variants, Pitfalls, and Artifacts?
Authors: Vangu Mboyo Di Tamba , Momodu Jaleelat I.
Published: February 2022

18F fluorodeoxyglucose ([F-18] FDG) PET-CT has gained popularity in the management of many types of malignancies. Today, imaging patients with lymphoma using of [F-18] FDG PET-CT not only is considered as a state-of-the-art tool but also has taken a central place for therapeutic decisions. In fact, accurate staging at diagnosis is imperative to prevent under treatment of individuals with advanced disease. In Hodgkin's lymphoma, in particular, the current role of interim [F-18] FDG PET imaging goes beyond speculations in the adaptation of different therapeutic strategies. Therefore, the use of such a critical imaging modality should go hand in hand with sound interpretation that provides accurate results. As the number patients referred for PET-CT continues to increase, imaging specialists should remain aware of the inherent limitations linked to the integrated imaging system that may introduce potential pitfalls related to the machine or the administered [F-18] FDG. Knowledge of the normal physiologic biodistribution of [F-18] FDG, its physiologic variants, and of all the potential pitfalls and artifacts is paramount to avoid misinterpretation. Recognition of the limitations of [F-18] FDG PET-CT will increase the confidence of practicing clinicians on the modality and impact positively on the management of patients. In this article, we will review the normal physiological variants, technical artifacts, and diagnostic pitfalls in lymphoma. Highlighting the limitations of [F-18] FDG PET-CT imaging should warn interpreting specialists to find measures that mitigate them and improve reporting results.
Postoperative Loss of Skeletal Muscle Mass Predicts Poor Survival After Gastric Cancer Surgery
Authors: Tan Shanjun , Zhuang Qiulin , Zhang Zhige , Li Shuhao , Xu Jiahao , Wang Junjie , Zhang Yanni , Xi Qiulei , Meng Qingyang , Jiang Yi , Wu Guohao
Published: February 2022

Background

Skeletal muscle mass deterioration is common in gastric cancer (GC) patients and is linked to poor prognosis. However, information regarding the effect of skeletal muscle mass changes in the postoperative period is scarce. This study was to investigate the link between postoperative loss of skeletal muscle mass and survival following GC surgery.

Methods

Patients who underwent GC surgery between January 2015 and December 2016 were recruited into the study. Computed tomography at L3 vertebral level was used to examine skeletal muscle index prior to surgery and about 6 months after surgery. Skeletal muscle index changes were categorized as presence or absence of ≥5% loss. Overall survival (OS) and disease-free survival (DFS) were analyzed, and Cox proportional hazard models used to identify their predictors.

Results

The study comprised of 318 gastric cancer patients of which 63.5% were male. The group's mean age was 58.14 ± 10.77 years. Sixty-five patients experienced postoperative skeletal muscle index loss ≥5% and had poorer OS (P = 0.004) and DFS (P = 0.020). We find that postoperative skeletal muscle index loss ≥ 5% predicts OS [hazard ratio (HR): 2.769, 95% confidence interval (CI): 1.865–4.111; P < 0.001] and DFS (HR: 2.533, 95% CI: 1.753–3.659; P < 0.001).

Conclusions

Loss of skeletal muscle mass postoperatively is linked to poor survival following GC surgery. Further studies are needed to determine whether stabilizing or enhancing skeletal muscle mass after surgery improves survival.
Simultaneous Image Reconstruction and Element Decomposition for Iodine Contrast Agent Visualization in Multienergy Element-Resolved Cone Beam CT
Authors: Wang Chao , Jung Hyunuk , Yang Ming , Shen Chenyang , Jia Xun
Published: February 2022

Iodine contrast agent is widely used in liver cancer radiotherapy at CT simulation stage to enhance detectability of tumor. However, its application in cone beam CT (CBCT) for image guidance before treatment delivery is still limited because of poor image quality and excessive dose of contrast agent during multiple treatment fractions. We previously developed a multienergy element-resolved (MEER) CBCT framework that included x-ray projection data acquisition on a conventional CBCT platform in a kVp-switching model and a dictionary-based image reconstruction algorithm that simultaneously reconstructed x-ray attenuation images at each kilovoltage peak (kVp), an electron density image, and elemental composition images. In this study, we investigated feasibility using MEER-CBCT for low-concentration iodine contrast agent visualization. We performed simulation and experimental studies using a phantom with inserts containing water and different concentrations of iodine solution and the MEER-CBCT scan with 600 projections in a full gantry rotation, in which the kVp level sequentially changed among 80, 100, and 120 kVps. We included iodine material in the dictionary of the reconstruction algorithm. We analyzed iodine detectability as quantified by contrast-to-noise ratio (CNR) and compared results with those of CBCT images reconstructed by the standard filter back projection (FBP) method with 600 projections. MEER-CBCT achieved similar contrast enhancement as FBP method but significantly higher CNR. At 2.5% iodine solution concentration, FBP method achieved 170 HU enhancement and CNR of 2.0, considered the standard CNR for successful tumor visualization. MEER-CBCT achieved the same CNR but at ~6.3 times lower iodine concentration of 0.4%.
Quantile Treatment Effect of Zinc Lozenges on Common Cold Duration: A Novel Approach to Analyze the Effect of Treatment on Illness Duration
Authors: Hemilä Harri , Chalker Elizabeth , Tukiainen Janne
Published: February 2022

Calculation of the difference of means is the most common approach when analyzing treatment effects on continuous outcomes. Nevertheless, it is possible that the treatment has a different effect on patients who have a lower value of the outcome compared with patients who have a greater value of the outcome. The estimation of quantile treatment effects (QTEs) allows the analysis of treatment effects over the entire distribution of a continuous outcome, such as the duration of illness or the duration of hospital stay. Furthermore, most of these outcomes have asymmetric distributions with fat tails, and censored observations are not uncommon. These features can be accounted for in the analysis of the QTE. In this paper, we use the QTE approach to analyze the effect of zinc lozenges on common cold duration. We use the data set of the Mossad (1996) trial with zinc gluconate lozenges, and three data sets of trials with zinc acetate lozenges. In the Mossad (1996) trial, zinc gluconate lozenges shortened common cold duration on average by 4.0 days (95% CI 2.3–5.7 days). However, the QTE analysis indicates that 15- to 17-day colds were shortened by 8 days, and 2-day colds by just 1 day, for the group taking zinc lozenges. Thus, the overall 4.0-day average effect of zinc gluconate lozenges in the Mossad (1996) trial is inconsistent with our QTE findings for both short and long colds. Similar results were found in our QTE analysis of the pooled data sets of the three zinc acetate lozenge trials. The average effect of 2.7 days (95% CI 1.8–3.3 days) was inconsistent with the effects on short and long colds. The QTE approach may have broad usefulness for examining treatment effects on the duration of illness and hospital stay, and on other similar outcomes.
The Effects of Syntactic Awareness to L2 Chinese Passage-Level Reading Comprehension
Authors: Zhou Jing
Published: February 2022

This study investigated the association between syntactic awareness and L2 Chinese passage-level reading comprehension among 209 Chinese as a second language adult-learners. The participants were administered a character knowledge test, a vocabulary knowledge test, a morphological awareness test, a grammatical judgment and correction test, a word order test, and two reading comprehension tests (multiple-choice questions and cloze test). Partial correlation analyses showed that the participants’ performance in two syntactic awareness tasks were significantly positively correlated with their passage-level reading comprehension. Multiple regression analyses revealed that syntactic awareness made a unique contribution to L2 Chinese reading even when the effects of age, major, gender, length of learning Chinese, character knowledge, vocabulary knowledge, and morphological awareness were controlled for. In addition, the word order knowledge had a stronger predicting power to L2 Chinese reading comprehension compared to the grammatical judgment/correction ability.
Antecedents and Consequences of Endorsing Prescriptive Views of Active Aging and Altruistic Disengagement
Authors: de Paula Couto M. Clara , Fung Helene H. , Graf Sylvie , Hess Thomas M. , Liou Shyhnan , Nikitin Jana , Rothermund Klaus
Published: February 2022

In this study, we investigated endorsement of two types of prescriptive views of aging, namely active aging (e.g., prescriptions for older adults to stay fit and healthy and to maintain an active and productive lifestyle) and altruistic disengagement (e.g., prescriptions for older adults to behave altruistically toward the younger generation by granting young people access to positions and resources). The study comprised a large international sample of middle-aged and older adults (N= 2,900), covering the age range from 40 to 90 years. Participants rated their personal endorsement of prescriptive views of active aging and altruistic disengagement targeting older adults in general (i.e., “In my personal opinion, older adults should…”). Findings showed that endorsement was higher for prescriptions for active aging than for prescriptions for altruistic disengagement. Age groups in the sample differed regarding their endorsement of both prescriptive views of active aging and altruistic disengagement with older adults showing higher endorsement than middle-aged adults did. Prescriptive views of active aging and altruistic disengagement related positively to each other and to the superordinate social belief that older adults should not become a burden, which attests to their functional similarity. In contrast, prescriptive views of active aging and altruistic disengagement were associated with psychological adjustment in opposite ways, with endorsement of active aging (vs. altruistic disengagement) being related to better (vs. worse) adjustment outcomes such as life satisfaction and subjective health. Our findings highlight the internalization of prescriptive views of aging in older people and their implications for their development and well-being.
Life Design Counseling: Theory, Methodology, Challenges, and Future Trends
Authors: Wen Ya , Li Kai , Chen Huaruo , Liu Fei
Published: February 2022

With the rapid development of society and the dramatic change of environment, previous career counseling focusing on personal choice has been difficult to meet individuals’ needs. It is very meaningful and valuable to introduce the ideology of Life Design Counseling (LDC). In this mini review, we introduce and analyze the theory and methodology of LDC. This review puts forward challenges in the field of LDC, including the lack of attention to clients from multiple backgrounds and professional counselors, the lack of diversified methods in the intervention process, and the lack of diversified research. The theoretical research, practical research, and the integration of theory and practice of LDC still need to be further concerned by researchers.
Expressed Emotion in the Family: A Meta-Analytic Review of Expressed Emotion as a Mechanism of the Transgenerational Transmission of Mental Disorders
Authors: Fahrer Julia , Brill Nathalie , Dobener Lisa Marie , Asbrand Julia , Christiansen Hanna
Published: February 2022

Background

High Expressed Emotion (HEE) has been identified as a risk factor for the exacerbation and course of mental illness. EE has been investigated as a caregiver's response to an offspring's problem behavior and pathology. The present meta-analysis regards EE from a transgenerational perspective and as one mechanism that might explain the transgenerational transmission of mental disorders.

Method

We identified a total of 13 studies relying on 16 independent samples of parent-child dyads of parents with a mental illness and healthy controls; these were included in our analysis. Results were synthesized into one effect size per sample; meta-regression on additional effects of parental diagnostic category, child mental illness, and child age were also applied.

Results

Parents with a mental illness are classified as HEE significantly more often. Effects were established for high criticism, albeit of small size (OR = 1.45), although they become stronger whenever offspring exhibit mental illness themselves (OR = 2.82).

Conclusion

The current study highlights the dearth of studies on EE in families in which a parent has a mental illness and its effects on their children. Our findings highlight EE as a potential mechanism for attributing the transgenerational transmission of mental disorders, especially for the EE-variable criticism, indicating dysfunctional parent-child interactions.

Systematic Review Registration

http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42019117609, identifier: CRD42019117609.
The Effect of Virtual Reality on Emotional Response and Symptoms Provocation in Patients With OCD: A Systematic Review and Meta-Analysis
Authors: Dehghan Bahram , Saeidimehr Saied , Sayyah Mehdi , Rahim Fakher
Published: February 2022

This systematic review and meta-analysis aimed to evaluate the effectiveness of virtual reality (VR)-based technology on emotional response and symptoms in patients with obsessive–compulsive disorder (OCD). We systematically searched major electronic databases, including PubMed/Medline, Scopus, Embase, ISI Web of Science, PsycINFO, and Cochrane central, up to April 14, 2021, with no data or language limits. We performed reference, related articles, and citation searches to find additional articles. We included original articles comparing and studying VR-based technology in patients with OCD against the control group. We observed that VR significantly increases in anxiety (SMD = 2.92; 95% CI 1.89–3.94, p < 0.0001; I2 = 95%), disgust (SMD = 2.52; 95% CI 1.36–3.68, p < 0.0001; I2 = 95%), urge to wash (SMD = 3.12; 95% CI 1.92–4.32, p < 0.0001; I2 = 94%), checking time (SMD = 1.06; 95% CI 0.71–1.4, p < 0.0001; I2 = 44%), number of checking behavior (SMD = 1.45; 95% CI 0.06–2.83, p = 0.04; I2 = 93%), and uncertainty (SMD = 2.59; 95% CI 0.90–4.27, p = 0.003; I2 = 70%) in OCD patients compared with healthy controls using a random-effect model. This meta-analysis found that this environment has a moderate enhancement in emotional response and symptoms test scores of patients with OCD. However, our findings should be generalized with caution due to the lack of standardized methods and high heterogeneity among included evidence. The appropriate mode of integrating VR-based technology for patients with OCD requires more exploration.
Patient Preferences for Diabetes Treatment Among People With Type 2 Diabetes Mellitus in China: A Discrete Choice Experiment
Authors: Huang Yuankai , Huang Qixiang , Xu Ailin , Lu Mengqing , Xi Xiaoyu
Published: February 2022

Introduction

Preferences for diabetes treatment-related attributes may be significant in diabetes management. However, there is a lack of evidence on patient preferences for diabetes in China.

Methods

A large-scale questionnaire survey was conducted in the hospitals of mainland China. Participants' preferences for six attributes were evaluated via a discrete choice experiment (DCE) using the conditional logit model. Patients' willingness to pay (WTP) for each attribute was calculated based on the cost attribute.

Results

The sample consisted of 709 patients (male 51.9%; female 48.1%). The results of the model indicated that patients' preference weight (PW) of days on which the blood glucose level is under control per week was the highest (1.41), and the PW of blood glucose monitoring frequency was the lowest (0.642). Patients were generally willing to pay for improvements in their type 2 diabetes mellitus (T2DM) treatment, and they had relatively higher WTP to avoid the blood glucose level within a normal value of 1 day/week (¥176.01) and also to avoid the frequency of hypoglycemic events within the range of 1–2/month (¥144.53).

Conclusion

The number of days on which the blood glucose level is under control per week is the most important attribute in the treatment choice for patients with T2DM in China, followed by the frequency of hypoglycemic events, medication regimen, weight change, and blood glucose monitoring.
Changes in Alcohol Consumption and Determinants of Excessive Drinking During the COVID-19 Lockdown in the Slovak Republic
Authors: Gavurova Beata , Khouri Samer , Ivankova Viera , Kubak Matus
Published: February 2022

As a result of the coronavirus disease 2019 (COVID-19) pandemic, countries have been forced to adopt strong restrictions, such as lockdown, which can lead to serious consequences for public health, including the problematic use of addictive substances. The aim of this cross-sectional study was to examine changes in alcohol consumption and to identify determinants against the background of excessive drinking during the COVID-19 lockdown in the Slovak Republic. The research included 445 respondents (33% males and 67% females), and the data collection through the questionnaire took place from April 29, 2020 to July 1, 2020. Measures such as drinking frequency, amount of alcohol and excessive drinking were used to examine alcohol consumption. Descriptive analysis and binary logistic regression were used to meet the main aim. The findings provide a closer look at the situation in the Slovak Republic and contribute to comprehensive international knowledge. The frequency of excessive drinking did not change in about half of respondents (53% of males and 69% of females). More respondents decreased their excessive drinking than increased, both among males (31 and 16%, respectively) and females (25 and 6%, respectively). Similar results were found for drinking frequency and amount of alcohol. Amongst Slovak respondents, an increase in excessive drinking was more common among males, younger people, smokers, and smokers who increased smoking during the lockdown. Especially in the case of vulnerable populations, public policies should consider a response to impending problems. The findings of this study encourage the implementation of effective and evidence-based prevention programs, which are more than necessary in the Slovak Republic.
The Racial Disparities in the Epidemic of Metabolic Syndrome With Increased Age: A Study From 28,049 Chinese and American Adults
Authors: Zhang Ruiying , Sun Jie , Wang Chaofan , Wang Xiangtuo , Zhao Pei , Yuan Yucong , Ai Hu , Zhou Qi
Published: February 2022

Background

Previous studies have revealed ethnic disparities in the prevalence of metabolic syndrome (MetS); however, the literature regarding aging-related patterns of disparities in MetS and its components remains limited.

Methods

This cross-sectional study recruited 28,049 subjects, consisting of one Chinese race and three American races, 18–85 years of age, from the National Health and Nutrition Examination Survey (NHANES, 1999–2018) of the United States, and the Guangdong Gut Microbiome Project (GGMP, 2018) of China. MetS was defined in accordance with the National Cholesterol Education Program Adult Treatment Panel III. A modified sliding-window-based algorithm was used to depict the trajectories of the prevalence of MetS with increased age. Logistic regression analysis was performed to investigate associations between MetS and its components.

Results

The prevalence of MetS increased non-linearly with age, with growth speed reaching its maximum at approximately 40–50 years. Chinese subjects exhibited a lower prevalence of MetS than non-Hispanic whites, non-Hispanic blacks, and Mexican Americans in all age groups. The two most prevalent components in Chinese subjects were reduced high-density lipoprotein cholesterol levels (42.0%) and elevated blood pressure (49.5%), and elevated triglyceride levels (36.3–49.5%) and abdominal obesity (55.8–55.9%) in Americans. Before 40 years of age, the top two MetS-associated components were abdominal obesity and elevated triglyceride levels in all races, while after 40 years, the prominent associations between MetS and its components varied among the different races and age groups.

Conclusions

Although racial disparities in the epidemic of MetS varied with increased age, abdominal obesity and elevated triglyceride levels were the top two MetS-associated components in all younger adults of different races.