bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of optimized frequency spectrum reuse (OFSR) for D2D communication in cellular network
Authors: Musefiu Aderinola  , Isiaka Shuaibu
Published: October 2022

Device to Device (D2D) communication in a cellular network poses some challenges among which are interference and low throughput. These two challenges can be controlled using optimized frequency spectrum reuse (OFSR). OFSR is technique where the user re-uses the frequency of another cell so as to prevent interference of D2D communication devices on the eNB as well as the interference on D2D receiver because of cellular user transmitters. The users were grouped in range of one –one hundred (1- 100), one to two hundred (1 – 200), one to three hundred (1-300) and one to four hundred (1-400). The simulation result obtained shows that OFSR has reduced interference when compared to resource allocation technique. The throughput in the down link is better when compare to the throughput in uplink as seen from the simulation result obtained.
Time series difference approach for evaluating sensitivity of nonlinear dynamic systems
Authors: Liming Dai  , Dandan Xia
Published: October 2022

This research is aimed to establish a novel approach for assessing sensitivities of nonlinear systems to initial conditions and system parameters via an evaluation of Time Series Difference. An evaluation method is proposed for measuring the differences of two trajectories representing the solutions of nonlinear systems, in responding to different initial conditions and/or system parameters. Recurrence relations are established for numerically evaluating the time series differences. Various nonlinear responses are evaluated with the approach proposed. A typical nonlinear dynamic system the Duffing system are considered for demonstrating the application of the approach in numerically and graphically assessing the sensitivities. The approach shown effectiveness in the assessment and can a useful tool for scientists and engineers in evaluating the initial-condition and system-parameter dependent sensitivities.
To prepare and evaluate orodispersible tablet of anti-inflammatory drug
Authors: Hemant Agrawal
Published: October 2022

Oral drug delivery remains the preferred route for administration of various drugs. Recent developments in the technology have prompted scientists to develop orally disintegrating tablets (ODTs) with improved patient compliance and convenience. Orodispersible tablets are solid unit dosage forms, which disintegrate or dissolve rapidly in the mouth without chewing and water. Orodispersible tablets provide an advantage particularly for pediatric and geriatric populations who have difficulty in swallowing conventional tablets and capsules. This review describes the various formulation aspects, disintegrant employed and technologies developed for ODTs, along with various excipients, evaluation tests, marketed formulations, and drugs explored in this field.
Mertic information and surface geometry
Authors: Vit Bytynaev
Published: October 2022

Mertic information and surface geometry
Differential expression of USP9Y in amyotrophic lateral sclerosis.
Authors: Mamoor Shahan
Published: October 2022

Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines ALS using published and public data (3, 4). We found significant differential expression of USP9Y, encoding ubiquitin specific peptidase 9, Y-linked, in the motor neurons of patients with ALS. USP9Y was also differentially expressed in the induced pluripotent stem cell (iPSC)-derived motor neurons of patients with ALS. USP9Y transcript was present at lower levels in ALS patient motor neurons as compared to control motor neurons. These analyses will begin to define the transcriptional landscape of ALS.
Alih Bahasa 26 Kumpulan Dongeng
Authors: Amanah Siti
Published: October 2022

Tulisan ini merupakan sebuah alih bahasa / terjemahan dari dongeng berbahasa Jawa. Dongeng adalah sebuah cerita yang bersifat khayalan dan tidak logis. Namun dongeng dapat dijadikan cara mendidik yang baik.
Differential expression of DIAPH1 in amyotrophic lateral sclerosis.
Authors: Mamoor Shahan
Published: October 2022

Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines ALS using published data (3, 4). We found significant differential expression of DIAPH1, encoding diaphanous-related formin 1, in the primary motor neurons of patients with ALS. DIAPH1 was also differentially expressed in the skeletal muscle of patients with ALS. DIAPH1 transcript was present at significantly lower levels in ALS patient motor neurons as compared to control motor neurons. These analyses will begin to define the transcriptional landscape of ALS.
A Prosocial Fake News Intervention with Durable Effects
Authors: Orosz Gabor , Paskuj Benedek , Faragó Laura , Krekó Péter
Published: October 2022

In contrast to prior individuum-focused interventions, the online randomized controlled trial presented here motivated young adults through family bonds to build resistance against fake news. This preregistered study is the first psychological fake news intervention in Eastern Europe, where the free press is weak and state-sponsored misinformation runs riot in mainstream media. In this intervention, participants were endowed with an expert role and requested to write a letter to their digitally less competent relatives explaining six strategies that help fake news recognition. Compared to the active control group there was an immediate effect (d=0.32) that persisted until the follow-up four weeks later (d=0.22) on fake news accuracy ratings. The intervention also reduced the bullshit receptivity of participants both immediately after the intervention and in the long run. The present work demonstrates the power of using relevant social bonds for motivating behavior change among Eastern Europeans. Our prosocial approach with its robust grounding in human psychology can open up new avenues in the fight against misinformation but we hold that leveraging these familial bonds could be the foundation of other behavior change efforts in the region.
Differential expression of GBP2 in amyotrophic lateral sclerosis.
Authors: Mamoor Shahan
Published: October 2022

Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines ALS using published data (3, 4). We found significant differential expression of GBP2, encoding guanylate binding protein 2, in the primary motor neurons of patients with ALS. GBP2 was also differentially expressed in the skeletal muscle of patients with ALS. GBP2 transcript was present at higher levels in ALS patient motor neurons as compared to control motor neurons. These analyses will begin to define the transcriptional landscape of ALS.
Improvement of Six Competency Skills through the Development of Flipped-Case Project in Era of Education 4.0
Authors: Hastuti Karunia Puji , Aristin Nevy Farista , Fani Ahmad Ilham Masful
Published: October 2022

The lack of research development on 21st-century learning models that can improve the six competency skills of Geography Education students at Universitas Lambung Mangkurat Indonesia and its integration in wetland environment management became the background for developing the Flipped-Case Project Model. This model results from the development of case methods and team-based projects, one of the efforts to improve six competency skills in learning innovation. This development consists of five stages: analysis, design, development, implementation, and evaluation. The results of this study showed that the novelty of the development of this model was seen in the learning syntax, including group formation, determining the topic of wetland management, mini-research, case finding by students, group discussion, presentation of reports, presentation of results, mini lecturers, and evaluation in the form of feedback. The Flipped-Case Project model has been declared feasible and effective for improving six competency skills as a learning model in the study of wetland environment management at the Geography Education Study Program, Universitas Lambung Mangkurat. The implications of this research as an alternative geography learning model that can improve students' six competency skills in the 4.0 education era. In addition, as a guide for further research to be implemented in other courses in higher education.
Faster when Fed: Satiated Individuals Inhibit (Food) Pictures Better Than Words
Authors: van den Hoek Ostende Mechteld Maria , Schwarz Ulrike , Gawrilow Caterina , Kaup Barbara , Svaldi Jennifer
Published: October 2022

In line with dual system models, it is often hypothesized that overeating occurs in tandem with lowered inhibitory control. Although there are some merits to this theory, the way (food) cues are represented, and how they influence inhibitory control, are not yet understood. Here, participants who fasted 12+ hours, or who ate within the previous 2 hours completed a stop-signal task with modal (pictures) and amodal (words) stimuli. In Study 1, there was a significant Group × Modality interaction which indicated that satiated, but not fasted individuals show better inhibitory capacity for modal relative to amodal stimuli. In line with previous theories, we also found evidence for better inhibitory control for satiated compared to fasted individuals, albeit for modal stimuli only. In Study 2, we additionally used non-food stimuli to test whether these effects were food-specific. While we were able to replicate the group by modality interaction, we did not find evidence for food specificity. Furthermore, the inhibitory advantage of satiated individuals compared to fasted individuals was not replicated. In all, we were able to show that metabolic state and stimulus type interact in their effect on inhibitory control in two pre-registered studies. These findings suggest that information of particular modalities is processed in distinct ways, depending on state factors.
Americans have a longer Digit span but a shorter Spatial span than Finns
Authors: Roivainen Eka
Published: October 2022

Americans have a longer Digit span but a shorter Spatial span than FinnsAbstractObjectiveCross-national studies of test norms show American superiority in digit span (DS) length as compared to European norms. In our study, American and Finnish DS and Spatial span (SS) norms were analyzed to study the hypothesis that the differences in DS reflect a systemic difference in working memory and are not based on linguistic factors.MethodThe mean DS and SS scores from the Wechsler Memory Scale III US (n=1250) and Finnish (n=251) standardizations were compared.ResultsA significant difference between American and Finnish mean DS (16.5-14.2) and SS (14.7-15.9) raw scores was observed. For six out of seven age groups, the American sample had longer DS while for 4/7 age groups, the Finnish sample had longer SS.Conclusions It is concluded that differences in DS are based on other factors than a systemic difference in working memory. The results underline the need for establishing national test norms for memory tests.
Open for Climate Justice: Intellectual Property, Human Rights, and Climate Change
Authors: Rimmer Matthew
Published: October 2022

This commentary highlights the history of conflict and division over intellectual property, technology transfer, and clean technologies during international climate negotiations. It considers the scope for open licensing to make environmental knowledge, data, technology, and intellectual property more widely accessible and available in order to better address climate adaptation and mitigation, as well as loss and damage. There has been a renewed interest in open access models for climate research, knowledge, and data. Creative Commons, SPARC and EIFL have launched a 4 year Open Climate Campaign, with funding from the Arcadia Foundation. The theme for the Open Access Week 2022 is Open for Climate Justice. Patent pledges have become increasingly popular as a means of sharing technologies. The Low Carbon Patent Pledge was launched in 2021 by Hewlett Packard Enterprise, Microsoft, and Facebook. The Pledge is designed to help disseminate clean technologies, subject to intellectual property rights. Meanwhile, the Government of Canada has experimented with patent collectives in the field of clean technologies. Open government policies have increasingly focused upon climate data, knowledge, and technologies. The Biden administration has been seeking to promote open innovation in the United States. At an international level, there has been discussion about the relationship between open science and human rights. The UNESCO Recommendation on Open Science provides a framework for the further development of policies in this field. While such new open source projects have promise, there is a need to scale up initiatives on open access, open data, open science, and open innovation to better address the challenges of climate change, biodiversity loss, and sustainable development.
Opening up Understanding of Neurodiversity: A Call for Applying Participatory and Open Scholarship Practices
Authors: Gourdon-Kanhukamwe Amélie , Kalandadze Tamara , Yeung Siu Kit , Azevedo Flavio , Iley Bethan Joan , Phan Jenny Mai , Ramji Anusha V. , Shaw John J , Zaneva Mirela , Dokovova Marie , Hartmann Helena , Kapp Steven K. , Warrington Kayleigh L , FORRT  , Elsherif Mahmoud Medhat
Published: October 2022

The preprint is about how participatory research movement and neurodiversity movement can benefit the open scholarship movement and vice versa, leading to a more generalisable and accurate science of human behaviour and cognition.
Embodied Cognitive Morphogenesis as a Route to Intelligent Systems
Authors: Alicea Bradly , Gordon Richard , Parent Jesse
Published: October 2022

The embryological view of development is that coordinated gene expression, cellular physics, and migration provides the basis for phenotypic complexity. This stands in contrast to the prevailing view of embodied cognition, which claims that informational feedback between organisms and their environment is key to the emergence of intelligent behaviors. We aim to unite these two perspectives as embodied cognitive morphogenesis, in which morphogenetic symmetry-breaking produces specialized organismal subsystems which serve as a substrate for the emergence of autonomous behaviors. As embodied cognitive morphogenesis produces fluctuating phenotypic asymmetry and the emergence of information processing subsystems, we observe three distinct properties: acquisition, generativity, and transformation. Utilizing a generic organismal agent, such properties are captured through models such as tensegrity networks, differentiation trees, and embodied hypernetworks, providing a means to identify the context of various symmetry-breaking events in developmental time. Related concepts that help us define this phenotype further include concepts such as modularity, homeostasis, and 4E (embodied, enactive, embedded, and extended) cognition. We conclude by considering these autonomous developmental systems as a process called connectogenesis, connecting various parts of the emerged phenotype into an approach useful for the analysis of organisms and the design of bio-inspired computational agents.
Migration to the metaverse and its predictors: attachment to virtual places and metaverse-related threat
Authors: Oleksy Tomasz , Wnuk Anna , Piskorska Małgorzata
Published: October 2022

The most ambitious visions of metaverse technology promise to create virtual places that offer the same possibilities as the real world. Implementation of these plans can become the next milestone on the road to the ongoing exodus from real places to digital ones. However, as any novel technology, the metaverse raises controversies and questions. Does one want to migrate to the metaverse? Does one’s willingness to move to virtual worlds depend on the bonds with existing virtual places and the sense of threat related to this technology? To address these questions, we drew on the theories of place attachment and intergroup threat. In two studies – (1) among users of open-world games (N = 366) and (2) using a sample representative of the Polish population in terms of age, gender and size of the residential place (N = 995) – we observed a low level of willingness to migrate to the metaverse. The participants displayed a high level of perceived metaverse-related threat, ranging from privacy concerns to the belief that metaverse can deprive one of access to essential human experiences. However, greater attachment to virtual, as opposed to real, places was associated with both an increased willingness to migrate to the metaverse and a low level of perceived threat. The results provide a better understanding of individuals’ perception of the metaverse and of how the bonds with virtual and real places translate into attitudes towards metaverse technology.
The COVID-19 Summary: Immunological Facts and Figures
Authors: Das Lipika , Dasgupta Debdeep
Published: October 2022

The recent Coronavirus disease (COVID-19) has disrupted health as well as economic status throughout the globe. In December 2019, a sudden outbreak of pneumonia originating from the Wuhan city of Hubei province, China, turned into the COVID-19 pandemic worldwide. The infectious agent was later identified and characterised as being part of the Coronavirus family and was named as Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) by the International Committee on Taxonomy. From several pieces of evidence, major similarities with the genome of bat CoVs, the origin of the virus was hypothesized to be zoonotic. Individuals affected by COVID-19 usually show common symptoms, including fever, dry cough, dyspnoea, hypoxemia, and pneumonia. Recent studies have revealed the role of the immune system in the pathogenesis of COVID-19 as the virus induces not only the host innate immunity but also impairs adaptive immunity and induces an uncontrolled inflammatory response, leading to disruption of normal immune homeostasis, tissue damage, and finally death by Respiratory failure. In this chapter, it discusses the immunopathogenesis of COVID-19. Up to date, there are no such appropriate treatments with proven efficacy available for COVID-19. Proper understanding of the involvement of the immune system in pathogenesis is important to designing an effective therapy against the infection.
ОЦІНКА ІНВЕСТИЦІЙНИХ РИЗИКІВ ВІРТУАЛЬНОЇ ІТ-КОМПАНІЇ НА ОСНОВІ МАШИННОГО НАВЧАННЯ
Authors: Ліп’яніна-Гончаренко Христина , Комар Мирослав , Саченко Анатолій , Лендюк Тарас
Published: October 2022

Розроблено модуль для оцінки інвестиційних ризиків віртуальної ІТ-компанії на основі машинного навчання, що дозволяє зменшити часові витрати на оцінку ризиків інвестора   віртуальної  ІТ-компанії . Проведено детальне обґрунтування кожного вибраного параметру-ризику, що впливає на  успішність інвестиційного проекту віртуальної ІТ-компанії. Алгоритм оцінки інвестиційних ризиків віртуальної ІТ-компанії на основі машинного навчання сформований на основі бального оцінювання 10 експертами  з 20 реалізованих проектів за 23 параметрами-ризиками. Проведено оцінку прогнозування з моделювання оцінки інвестиційних ризиків віртуальної ІТ-компанії використовуючи  машинне навчання на основі восьми методів: Support Vector Classifier, Stochastic Gradient Decent Classifier, Random Forest Classifier, Decision Tree Classifier, Gaussian Naive Bayes, K-Neighbors Classifier, Ada Boost Classifier, Logistic Regression. Та розроблено модуль для підтримки прийняття рішень на основі трьох методів з найкращим показником прогнозу, а саме: Support Vector Classifier, Random Forest Classifier, K-Neighbors Classifier.
МЕТОД СТРУКТУРНОЇ ІДЕНТИФІКАЦІЇ ІНТЕРВАЛЬНИХ ДИСКРЕТНИХ МОДЕЛЕЙ СКЛАДНИХ ОБ’ЄКТІВ ІЗ АДАПТИВНИМ НАЛАШТУВАННЯМ ВИБОРУ СТРУКТУРНИХ ЕЛЕМЕНТІВ
Authors: Мельник Андрій , Дивак Микола
Published: October 2022

Розглянуто задачу структурної ідентифікації інтервальних дискретних моделей складних об’єктів та метод її розв’язування на основі поведінкової моделі бджолиної колонії. Досліджено особливості реалізації цього методу. Встановлено, що під час формування структур на різних фазах обчислювальної схеми методу здійснюємо вибір із множини елементів випадково і заміну структурних елементів здійснюємо також випадково. В основі такого вибору покладено рівномірний закон розподілу.

Спираючись на ці факти, сформульовано задачу про  необхідність встановлення приорітетності обрання структурних елементів із множини для формування оптимальної, в сенсі задачі структурної ідентифікації структури інтервальної дискретної моделі, що у підсумку забезпечить зниження обчислювальної складності методу структурної ідентифікації інтервальних дискретних моделей складних об’єктів.  

В роботі запропоновано та обґрунтовано новий метод структурної ідентифікації інтервальних дискретних моделей складних об’єктів, який на відміну від існуючих, містить обчислювальні процедури адаптивного налаштування вибору структурних елементів у спосіб встановлення для кожного елемента множини структурних елементів ймовірності вибору будь-якого елемента і на основі зміни цього розподілу на різних фазах поведінкової моделі бджолиної колонії, що у сукупності знижує обчислювальну складність реалізації методу.
Tinjauan penerapan pendaftaran online pasien rawat jalan di RS. Yadika Kebayoran Lama
Authors: Meliana Meliana , Widhi Joko Asmoro , Syarafina Royda
Published: October 2022

Tempat penerimaan pasien merupakan tempat pertama kali pasien bertemu dengan petugas secara langsung di fasilitas kesehatan. Dengan menerapkan teknologi didambakan bisa membuat kerja perekam medis lebih efektif dan efisien serta dapat mengurangi masalah yang ada. Penerapan sistem pendaftaran online dilakukan sebagai jalan keluar masalah pasien ditempat penerimaan pasien. Tujuan umumdari penelitian ini adalah  diketahuinya gambaran penerapan sistem pendaftaran online pasien rawat jalan. Sedangkan tujuan khusunya yaitu mengetahui prosedur (SPO) penerapan sistem pendaftaran online pasien rawat jalan, mengetahui penerapan  sistem pendaftaran online pasien rawat jalan, mengetahui kendala penerapan sistem pendaftaran online pasien rawat jalan di RS Yadika Kebayoran Lama. Metode penelitian yang digunakan adalah metode penelitian deskriptif. Dari hasil penelitian dilakukan penulis di bagian pendaftaran bahwa  waktu pelayanan pendaftaran rawat jalan mulai dari pasien mendaftar sampai mendapat nomor antrian mayoritas kurang dari lima menit. Presentase waktu pelayanan pendaftaran rawat jalan  ≥ 5 menit sebesar 4,21% sedangkan, presentase waktu pelayanan pendaftaran rawat jalan  ≤  5 menit sebesar 95,97%. Saran dari penulis sebaiknya mulai menyusun pembuatan SPO terkait pendaftaran pasien online. RS perlu menyiapkan aplikasi pendaftaran online agar segera disetujui penggunaanya oleh pusat dan pelaksanaan sistem pendaftaran bisa dioperasikan secara konsisten.
ANALISIS KETENAGAAN PENGELOLA REKAM MEDIS & INFORMASI KESEHATAN DI PUSKESMAS SRONDOL
Authors: Lestari Sri , Hapsari Meilinda Asrining
Published: October 2022

Puskesmas in carrying out health services, one of its authorities is to carry out medical record management. Referring to Permenkes no. 55 of 2013 article 2 which states that the administration of medical records must be carried out by medical recorders. Medical Recorder is a person who has passed the Medical Record and Health Information education in accordance with the provisions of the legislation.The purpose of this research is to know the management of medical records, and health information as well as the staff for managing medical records at the Srondol Health Center. This type of research is descriptive qualitative with a case study approach.The results showed that the Srondol Health Center provided health services to BPJS patients and general patients. The patient naming system at the Srondol Health Center is adjusted to ID cards, family cards and other identity cards. Medical record management activities experienced several obstacles because they did not have officers with a medical record education background so that the transfer of medical record media from manual to electronic was constrained. The writing of patient names (Mr, Ny, Son, Br) is not standardized. Diagnostic coding is only known and carried out by doctors and midwives.The conclusion obtained is that the management of medical records and health information at the Srondol Health Center still found some things that were not in accordance with the regulations, so it was advisable to make adjustments to the medical record personnel regulations to improve their services.
Comprehensive Analysis of Long Non-Coding RNAs N4-Acetylcytidine in Alzheimer’s Disease Mice Model Using High-Throughput Sequencing
Authors: Ma Yanzhen , Li Weizu , Fan Chang , Wang Yongzhong , Jiang Hui , Yang Wenming
Published: October 2022

Background: N4-acetylcytidine (ac4C), an important posttranscriptional modification, is involved in various disease processes. Long noncoding RNAs (lncRNAs) regulate gene expression mainly through epigenetic modification, transcription, and posttranscriptional modification. Alzheimer’s disease (AD) is a neurodegenerative disease characterized by amyloidosis of the brain. However, the role of lncRNA ac4C modification in AD remains unclear. Objective: In this study, we investigated the association between ac4C modification and AD, and the underlying mechanisms of ac4C modification in AD. Methods: The male 9-month-old APP/PS1 double transgenic mice, age- and sex-matched wild type (WT) mice were used in this study. Then, ac4C-RIP-seq and RNA-seq were used to comprehensively analyze lncRNA ac4C modification in AD mice. The lncRNA-miRNA-mRNA regulatory networks using Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses showed the regulatory relationships among these three lncRNAs and AD. Results: The results showed that there were 120 significantly different ac4C peaks located on 102 lncRNAs in AD, of which 55 were hyperacetylated and 47 were hypoacetylated. Simultaneously, 231 differentially expressed lncRNAs were identified, including 138 upregulated lncRNAs and 93 downregulated lncRNAs. Moreover, 3 lncRNAs, lncRNA Gm26508, lncRNA A430046D13Rik, and lncRNA 9530059O14Rik, showed significant changes in both the ac4C and RNA levels using conjoint analysis. Conclusion: The abundance of lncRNA ac4C modification is significantly different in AD and indicates that lncRNA ac4C is associated with the occurrence and development of AD, which could provide a basis for further exploration of the related regulatory mechanisms.
Impact of Cigarette Smoking and Its Interaction with Hypertension and Diabetes on Cognitive Function in Older Americans
Authors: Restifo Daniel , Zhao Chen , Kamel Hooman , Iadecola Costantino , Parikh Neal S.
Published: October 2022

Background: The detrimental impact of tobacco smoking on brain health is well recognized. Objective: To evaluate whether smoking acts synergistically with hypertension and diabetes to influence cognitive performance. Methods: We performed a cross-sectional analysis using the US National Health and Nutrition Examination Survey. Participants were tested for serum cotinine, a validated cigarette smoking/exposure biomarker, and had standardized blood pressure and hemoglobin A1c measurements. Participants were administered four cognitive tests: Digit Symbol Substitution (DSST), Animal Fluency, Immediate Recall, and Delayed Recall. Multivariable linear regression models adjusted for demographics and confounders evaluated the association of cotinine with cognition. Interaction testing evaluated effect modification by hypertension, diabetes, and their continuous measures (systolic blood pressure and hemoglobin A1c). Results: For 3,007 participants, mean age was 69.4 years; 54% were women. Using cotinine levels, 14.9% of participants were categorized as active smokers. Higher cotinine levels were associated with worse DSST performance when modeling cotinine as a continuous variable (β, -0.70; 95% CI, -1.11, -0.29; p < 0.01) and when categorizing participants as active smokers (β, -5.63; 95% CI, -9.70, -1.56; p < 0.01). Cotinine was not associated with fluency or memory. Effect modification by hypertension and diabetes were absent, except that cotinine was associated with worse Immediate Recall at lower blood pressures. Conclusion: Higher levels of a smoking and secondhand exposure biomarker were associated with worse cognitive performance on a multidomain test. Overall, the relationship of cotinine with cognition was not contingent on or amplified by hypertension or diabetes; smoking is detrimental for brain health irrespective of these comorbidities.
The CCL2 rs4586 SNP Is Associated with Slower Amyloid-β Deposition and Faster Tau Accumulation of Alzheimer’s Disease
Authors: Gao Fan ,   Alzheimer’s Disease Neuroimaging Initiative, Zhang Peng-Fei , Gao Jing , Song Jinghui , Chi Song
Published: October 2022

Background: CC-chemokine ligand 2 (CCL2), the key immunomodulatory chemokine for microglial activation, has been implicated in the pathogenesis of Alzheimer’s disease (AD). Whether the association of CCL2 single nucleotide polymorphisms (SNPs) and the risk of AD is still controversial. Objective: We aimed to investigate whether CCL2 rs4586 SNP is associated with the pathological changes and cognitive decline of AD. Methods: A total of 486 participants with longitudinal cerebrospinal fluid (CSF) amyloid-β (Aβ) and phospho-tau (P-tau) biomarkers, 18F-Florbetapir and 18F-flortaucipir-positron emission tomography (PET), and cognitive assessments from the Alzheimer’s disease Neuroimaging Initiative were included in the study. The effects of CCL2 rs4586 SNP on the pathological changes and cognitive decline of AD were assessed with linear mixed-effects models and evaluated according to the Aβ-status so as to identify whether the effects were independent of Aβ status. Results: CCL2 rs4586-CC carriers exhibited a slower global Aβ-PET accumulation, particularly within stage I and stage II. However, they exhibited a faster accumulation of CSF P-tau and global tau-PET standard uptake value ratios, especially in Braak I and Braak III/IV and the inferior temporal gyrus. The congruent effects of CCL2 rs4586 on tau accumulation existed only in the Aβ–group, as is shown in global tau-PET and Braak I. However, CCL2 rs4586 was not associated with the cognitive decline. Conclusion: Our findings showed that the CCL2 rs4586-CC (versus TT/TC) genotype was associated with slower Aβ deposition and faster tau accumulation, and the latter of which was independent of Aβ status.
COVID-19 as a Risk Factor for Alzheimer’s Disease
Authors: Golzari-Sorkheh Mahdieh , Weaver Donald F. , Reed Mark A.
Published: October 2022

Severe acute respiratory disease coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19) pandemic. Although a primarily respiratory disease, recent reports indicate that it also affects the central nervous system (CNS). Over 25% of COVID-19 patients report neurological symptoms such as memory loss, anosmia, hyposmia, confusion, and headaches. The neurological outcomes may be a result of viral entry into the CNS and/or resulting neuroinflammation, both of which underlie an elevated risk for Alzheimer’s disease (AD). Herein, we ask: Is COVID-19 a risk factor for AD? To answer, we identify the literature and review mechanisms by which COVID-19-mediated neuroinflammation can contribute to the development of AD, evaluate the effects of acute versus chronic phases of infection, and lastly, discuss potential therapeutics to address the rising rates of COVID-19 neurological sequelae.
WDBA method for probabilistic linguistic MAGDM with entropy weight and application to consumer competitiveness evaluation in creative and cultural industries
Authors: Liu Shengyan , Zhou Yao , Wang Xiao
Published: October 2022

With the steady development of China’s economy, under the new economic normal, the creative cultural industry has been continuously optimized and developed in terms of structure, scale and quality, and the connotation of the creative cultural industry has been continuously enriched, forming a three-dimensional and diversified pattern. With the help of high-tech, culture, multimedia and other means, the current creative cultural industry is continuously absorbing and integrating it on a large scale, promoting the optimization, upgrading and innovative development of the industry. The consumer competitiveness evaluation in creative and cultural industries is a classical MAGDM problems. In this paper, WDBA method is designed for solving the probabilistic linguistic MAGDM(PL-MAGDM) with the completely unknown weights. In the end, an empirical application for consumer competitiveness evaluation in creative and cultural industries is used to demonstrate the use of the developed method. The proposed method can also contribute to the selection of suitable alternative successfully in other selection problems.
Bone Quality in Patients with a Congenital Myopathy: A Scoping Review
Authors: Bouman Karlijn , Dittrich Anne T.M. , Groothuis Jan T. , van Engelen Baziel G.M. , Janssen Mirian C.H. , Voermans Nicol C. , Draaisma Jos M.T. , Erasmus Corrie E.
Published: October 2022

Background:

Congenital myopathies are rare neuromuscular disorders presenting with a wide spectrum of clinical features, including long bone fractures (LBFs) that negatively influence functional prognosis, quality of life and survival. Systematic research on bone quality in these patients is lacking.

Objective:

This scoping review aims to summarize all evidence on bone quality and to deduce recommendations for bone quality management in congenital myopathies.

Methods:

Five electronic databases (Pubmed, Embase, Cochrane, Web of Science, CINAHL) were searched. All studies on bone quality in congenital myopathies were included. Decreased bone quality was defined as low bone mineral density and/or (fragility) LBFs. Study selection and data extraction were performed by three independent reviewers.

Results:

We included 244 single cases (mean: 4.1±7.6 years; median: 0 years) diagnosed with a congenital myopathy from 35 articles. Bone quality was decreased in 93 patients (37%) (mean: 2.6±6.8 years; median: 0 years). Low bone mineral density was reported in 11 patients (4.5%) (mean: 10.9±9.7; median: 11 years). Congenital LBFs were reported in 64 patients (26%). (Fragility) LBFs later at life were described in 24 patients (9.8%) (mean: 14.9±11.0; median: 14 years). Four cases (1.6%) were reported to receive vitamin D and/or calcium supplementation or diphosphonate administration.

Conclusion:

LBFs are thus frequently reported in congenital myopathies. We therefore recommend optimal bone quality management through bone mineral density assessment, vitamin D and calcium suppletion, and referral to internal medicine or pediatrics for consideration of additional therapies in order to prevent complications of low bone mineral density.
SETD2 Regulates the Methylation of Translation Elongation Factor eEF1A1 in Clear Cell Renal Cell Carcinoma
Authors: Hapke Robert , Venton Lindsay , Rose Kristie Lindsay , Sheng Quanhu , Reddy Anupama , Prather Rebecca , Jones Angela , Rathmell W. Kimryn , Haake Scott M.
Published: October 2022

BACKGROUND:

SET domain-containing protein 2 ( SETD2) is commonly mutated in renal cell carcinoma. SETD2 methylates histone H3 as well as a growing list of non-histone proteins.

OBJECTIVE:

Initially, we sought to explore SETD2-dependent changes in lysine methylation of proteins in proximal renal tubule cells. Subsequently, we focused on changes in lysine methylation of the translation elongation factor eEF1A1.

METHODS:

To accomplish these objectives, we initially performed a systems-wide analysis of protein lysine-methylation and expression in wild type (WT) and SETD2-knock out (KO) kidney cells and later focused our studies on eEF1A1 as well as the expression of lysine methyltransferases that regulate its lysine methylation.

RESULTS:

We observed decreased lysine methylation of the translation elongation factor eEF1A1. EEF1AKMT2 and EEF1AKMT3 are known to methylate eEF1A1, and we show here that their expression is dependent on SET-domain function of SETD2. Globally, we observe differential expression of hundreds of proteins in WT versus SETD2-KO cells, including increased expression of many involved in protein translation. Finally, we observe decreased progression free survival and loss of EEF1AKMT2 gene expression in SETD2-mutated tumors predicted to have loss of function of the SET domain.

CONCLUSION:

Overall, these data suggest that SETD2-mutated ccRCC, via loss of enzymatic function of the SET domain, displays dysregulation of protein translation as a potentially important component of the transformed phenotype.
Influence of agility and core endurance on visual reaction time in amateur male badminton players
Authors: Prabhu Chaitali , Kulkarni Neha , Palekar Tushar J.
Published: October 2022

BACKGROUND: Badminton depends on key factors like reaction time, agility and core endurance to deliver a powerful and precise stroke. The purpose of this study is to explore the associations between agility and core endurance on visual reaction time among adult male amateur badminton players. MATERIALS AND METHODS: Amateur male badminton players between 12–25 years were recruited and assessed on visual reaction time, agility and core endurance using deary liewald reaction time software, T test and prone bridge test respectively. Pearson correlation test was used to analyze the data for correlation while Mann Whitney U test was used to find the difference, if any, between the adolescent and adult players in terms of reaction time, agility and core endurance. Data analysis was done using SPSS software version 23. RESULT: Ninety amateur male badminton players in the age group of 12–25 years were included in the study. Data analysis was done for adolescent players (n = 45 of 12–17 years) and young adult players (n = 45 of 17–25 years). A positive correlation was obtained between reaction time and agility in both adolescents’ and young adults and the entire population with r value 0.413, 0.082, and 0.244 respectively. A negative correlation was seen between reaction time and core endurance in adolescents, young adults and whole group with r value –0.283, –0.267, –0.272 respectively. CONCLUSION: Amateur badminton players who had good agility displayed faster reaction time while those having poor core endurance showed slower reaction time.
MADLINK: Attentive multihop and entity descriptions for link prediction in knowledge graphs
Authors: Biswas Russa , Sack Harald , Alam Mehwish
Published: October 2022

Knowledge Graphs (KGs) comprise of interlinked information in the form of entities and relations between them in a particular domain and provide the backbone for many applications. However, the KGs are often incomplete as the links between the entities are missing. Link Prediction is the task of predicting these missing links in a KG based on the existing links. Recent years have witnessed many studies on link prediction using KG embeddings which is one of the mainstream tasks in KG completion. To do so, most of the existing methods learn the latent representation of the entities and relations whereas only a few of them consider contextual information as well as the textual descriptions of the entities. This paper introduces an attentive encoder-decoder based link prediction approach considering both structural information of the KG and the textual entity descriptions. Random walk based path selection method is used to encapsulate the contextual information of an entity in a KG. The model explores a bidirectional Gated Recurrent Unit (GRU) based encoder-decoder to learn the representation of the paths whereas SBERT is used to generate the representation of the entity descriptions. The proposed approach outperforms most of the state-of-the-art models and achieves comparable results with the rest when evaluated with FB15K, FB15K-237, WN18, WN18RR, and YAGO3-10 datasets.
Вплив технологій доповненої реальності на кардіологічні показники курсантів НАНГУ під час тренувальної імітації виконання бойового завдання
Authors: Chala Sofia , Lutsak Olena , Hrynzovskyi Anatolii , Chernenko Lyudmila , Kalashchenko Svitlana , Fedosov Yuriy , Drapey Ihor , Martynenko Serhii , Boyko Yuliia , Chayka Yuriy
Published: October 2022

на сьогоднішній день, в умовах проведення військових дій на території України, значно зростає необхідність навчання та підготовки курсантів вищих військових навчальних закладів (ВНЗ) для успішного виконання різноманітних бойових завдань та готовність курсантів до виконання цих завдань в умовах значного психоемоційного, нервового та фізичного навантаження. Найкращій спосіб досягти максимального рівня готовності курсантів вищих ВНЗ – це проведення тренувальної імітації виконання бойового завдання. Проте, результати аналізу технічної та спеціальної підготовки особового складу екіпажів бойових машин вказують на недостатній рівень підготовки вищезазначених екіпажів, що не забезпечує виконання бойових завдань у повному обсязі. Під час навчального процесу недостатньо часу присвячено заняттям на навчально-тренажерних засобах. Для кращого відбору осіб, які мають проводити свою професійну діяльність в умовах хронічного стресу, постійного ризику для свого життя та здоров’я, вбачається актуальним розглянути питання оцінки кардіологічних показників курсантів при виконанні тренувальних імітацій  бойового завдання. Метою нашої роботи є отримання та аналізування даних моніторингу базових показників роботи серця у категорії здорових чоловіків віком 18-31 років, які навчаються в Національної академії Національної гвардії України (НАНГУ), із метою оцінки кардіологічних показників толерантності в ході тренувальної імітації виконання бойового завдання. Було обстежено 88 курсантів 3-го та 4-го курсів НАНГУ. В дослідження не були включені курсанти з наявними хронічними захворюваннями у фазі загострення, з наявними гострими респіраторними захворюваннями, ознаками психо-емоційного перевантаження, віком менше ніж 18 років а також ті, що відмовились від проведення обстеження. Для імітації бойового завдання нами був використаний навчально-тренувальний комплексу БТР-4Е, оснащений бойовим модулем «Парус». Реакція серцево-судинної системи курсантів на тренувальне навантаження характеризується статистично значущим (p=0,025) збільшенням значенням амплітуди піків Т, зменшенням значення амплітуди піків P (p<0,001) та зменшенням ЧСС (p<0,001) при проведенні вимірювань негайно після завершення вправи. Нашими дослідженнями встановлено, що релаксація і швидке відновлення кардіологічних показників до значень характерних для стану спокою відбувається за 1-3 хвилини після завершення тренувальної імітації виконання бойового завдання. Це свідчить про те, що використання імерсійних технологій (в нашому випадку технологій доповненої реальності) має позитивний вплив на  вегетативну регуляцію у курсантів.
SECTORS INVOLVED IN PUBLIC HEALTH IN THE RUSSIAN FEDERATION DURING COVID-19 PANDEMIC
Authors: Reshetnikov V. A. , Korshever N. G. , Royuk V. V. , Sidelnikov S. A.
Published: October 2022

The article develops a research agenda for cross-sectoral collaboration on the issues of public health. The aspects of this collaboration are not scientifically founded during the COVID-19 pandemic.The aim of the research is to study the inventory of the sectors involved in public health in the Russian Federation during the COVID-19 pandemic and to put in perspective their importance.An anonymous survey of 49 experts - health service managers was made. The respondents were asked to identify the inventory of the sectors involved in public health and to voice their opinion on their importance during the COVID-19 pandemic. The results of the survey were compared to the results obtained before the pandemic.The results of the study suggest that 23 sectors should always be involved in public health both during the COVID-19 pandemic and without it. The sectors are of relatively equal importance. However, the sectors of the inventory are ranked differently in the order of importance during the pandemic and without it. A statistically significant difference in the analysed characteristic feature is noted.The article develops a research agenda for further studies and provide implications for health-service managers.
HYGIENIC ASSESSMENT OF NUTRITION AND INCIDENCE OF INDIVIDUAL DISEASES OF STUDENT’S SECONDARY PROFESSIONAL EDUCATION IN MODERN CONDITIONS
Authors: Akishin S. V. , Dementiev A. A. , Kharitonov V. I. , Zdolnik T. D. , Lyapkalo A. A. , Kazaeva O. V.
Published: October 2022

The primary prevention of a significant number of diseases today is based on the principles of a healthy lifestyle which are the most important conditions for maintaining and strengthening the health of the population. At the same time, one of the main tasks is to optimize the nutritional status, preserve and improve the health of certain groups of the population and, above all, children and adolescents. The purpose of the work is a hygienic assessment of the characteristics of the nutritional status and nutritional health of young students and the scientific substantiation of recommendations for their optimization. It has been established that the insufficient level of knowledge of the basics of a healthy lifestyle and the existing shortcomings in the organization of nutrition of adolescents, as well as economic factors, lead to an inadequate nutritional status of students in secondary professional education, which is expressed in the low energy value of the diet, its imbalance and lack of diversity, as well as its low provision with macronutrients, vitamins and minerals. There is a significant increase in the incidence of diseases of the digestive system from junior to senior years, which allows us to consider college education as a risk factor for diseases of this class.