bluuebunny/crossref_metadata_2025 huggingface dataset:
Study of Virtual Molecular Docking of Avocados Compounds against Pseudomonas aeruginosa (5N5H) by Carbapenemase using DOCK 6 Algorithm
Authors: Ulayya Hanidya Fidela , Nursayyida Arifa , Atmaja Fabiola Irianty , Santoso Broto
Published: December 2022

Antimicrobial resistance from bacteria is a global health problem that can cause death, and the cause is the emergence of carbapenem resistance Pseudomonas aeruginosa through VIM (Verona integron-encode metallo-β-lactamase), which causes the carbapenem class of antibiotics not to work properly. This species is a gram-negative bacteria which is the main cause of nosocomial pneumonia infection. This study aims to determine in silico inhibitory activity of 50 compounds obtained from avocado (Persea Americana Mill) on VIM, preventing carbapenem antibiotic resistance. The molecular docking process was carried out to test carbapenem's antibiotic resistance control activity by 50 compounds. Docking using DOCK 6 software with a flexible and rigid method, Molecular docking on a protein with PDB ID 5N5H, The target protein was prepared using the Chimera application. Visualization of ligand-protein interactions was carried out with PyMOL and PLIP. The results of the native ligand grid score obtained by each method are -63.013 kcal/mol (Flexible) and -64.032 kcal/mol (Rigid). The best test ligands in the flexible method are 44257090, 14282775 and 44257819, and the grid score are -77.474, -75.274 and -73.219 kcal/mol. The best test ligands in the rigid method are 5280637, 14282775 and 5490064; the grid score is -62.191, -61.714, and -60.453 kcal/mol. The results of the test ligands can provide a better grid score than native ligands, namely in the flexible method. However, the rigid method of grid score results is no better than the native ligand. A good result is that the test ligand grid score is smaller than native ligands, so it has less energy to bind to the active site.
Effect of Chitosan Concentration on Macroporous Chitosan-TPP Beads toward Turbidity, Dye Content, and COD of Sasirangan Wastewater
Authors: Ariyani Dahlena , Mujiyanti Dwi Rasy , Santoso Uripto Trisno , Maulana Riana , Rohmah Retno Elya , Irawati Utami
Published: December 2022

This research was carried out to determine the effect of chitosan concentration in synthesising crosslinked tripolyphosphate (TPP) macropore beads on turbidity, dye content, and Chemical of Demand (COD) Sasirangan wastewater. Macroporous chitosan-TPP beads were synthesised from chitosan solution with various concentrations of 2%, 3%, 4%, and 5% and added NaHCO3 as a porogen, then dripped into 0.75% tripolyphosphate solution. It was further interacted with Sasirangan wastewater by adsorption method with its effect analysed by using the turbidity value, dye content, and COD. The results showed that beads with a 3% chitosan concentration were the most effective in reducing the turbidity, dye content, and COD value. Furthermore, using a more than 3% chitosan concentration indicates reduced effectiveness. Macroporous Chitosan-TPP beads were able to produce a decrease in turbidity, dye content and COD by 81.21%, 55.44%, and 59.37%. 
Preparation and Characterization of Adsorbent from Natural Zeolite Mixed Chicken Feather in Degradation of Batik Waste Dyes Based Green Chemistry
Authors: Latifah Rais Nur
Published: December 2022

This research is the adsorption of dyestuffs from batik industry waste. The adsorption method was used chicken feather adsorbent with natural zeolite. Zeolite was activated by HF. Feather flour was activated with 0.2 M KOH. The main focus of this research is determine the potential for dye degradation with the batch method.Samples were analyzed by Atomic Absorption Spectroscopy (AAS), Fourier Transform Infra Red Spectrophotometer (FTIR), and Surface Area Analyzer (SAA). Measurement of dye degradation includes the effect of adsorbent concentration, pH, contact time and particle size of adsorbent. The results showed that the optimum pH in the degradation of dyestuffs from the batik industry waste was pH 8.5. The optimum contact times by activated and unactivated adsorbents were 65 minutes and 120 minutes, respectively. The reaction kinetics analysis showed the Freundlich adsorption model based on the  experimental data. This indicates that the surface pores of the adsorbent are very influential in the degradation of the dye. Adsorption capacity of degradation dyestuffs with adsorbents has an efficiency of 94%. In the laboratory, it  has been proven that adsorbents are able to degrade dyes in batik waste before being discharged into the water disposal system.
Synthesin and Characterization Chitosan Film with Silver Nanoparticle Addition As A Multiresistant Antibacteria Material
Authors: Susilowati Endang , Ariani Sri Retno Dwi , Mahardiani Lina , Izzati Luthfia
Published: December 2022

The synthesis of chitosan films with the addition of silver nanoparticles (AgNps) has been carried out in 2 stages. The first stage is to make colloidal silver nanoparticles with chitosan as a stabilizer and a reducing agent with NaOH as an accelerator and assisted by microwave irradiation. The second stage is to make a film from colloidal silver nanoparticles-chitosan by casting method. The formation of silver nanoparticles was identified using a UV-Vis spectrophotometer and TEM. Chitosan films with the addition of AgNps were characterized by chemical, physical and mechanical properties. Furthermore, the antibacterial activity was tested against multi-resistant bacteria ESBL and MRSA. The results showed that the formation of AgNps was indicated by the appearance of an absorption band at 400-413 nm with a size of less than 6 nm. The FTIR spectra showed that there was a slight shift at the 1604 cm-1 peak which indicated that the AgNps interacted with the NH2 group on D-glucosamine of chitosan. The films morphology with addition Ag NPs tends to be rough in surface and cross-sectional. The presence of AgNps tends to increase the swelling value, tensile strength and film elasticity. Chitosan film with the addition of silver nanoparticles has antibacterial activity against multi-resistant bacteria ESBL and MRSA. The anti-bacterial activity of the film was derived solely from the silver nanoparticles.
Metal Ion Complex Compound Fe(III) with Pyrazoline Derivative Ligand as Cd(II) and Zn(II) Heavy Metal Ion Sensor Based on Fluorescence
Authors: Syahputri Yulian , Iryani Ani , Kusumawardani Linda Jati , Safitri Shinta
Published: December 2022

The purpose of this research is to synthesize the complex compound of ion Fe3+ with para-di-2-(1-phenyl-3-pyridyl-4,5-dihydro-1H-pyrazole-5-yl)benzene ligand and its potentials as the sensor of Cd2+ and Zn2+ heavy metal ions based on fluorescence. Complex compounds are characterized with a Fourier-Transform Infrared (FTIR) Spectrophotometer, Ultraviolet-Visible (UV-Vis) Spectrophotometer and Spectrofluorometer. Then, a complex compound fluorosensor study is conducted by adding Cd2+ and Zn2+ heavy metal ions using a UV-Vis Spectrophotometer and Spectrofluorometer. The results show that the synthesis of the complex compound formed by reacting Fe metal and pyrazoline derived ligands generates brown precipitate with a yield of 51.25% and a range of melting points of  252.2-253.2 . The result of characterization with FTIR (cm-1) generates 3380.20 (tertiary amine), 2922.31-2852.42 (C-H pyridine), 2360.38 (C=C aromatic), 1595.93-1451.88 (C=N), 1232.25-982.66 (C-N pyrazoline), 751.61-690.29 (C-H aromatic) and 366.54-339.44 (Fe-N). The Uv-Vis spectrophotometer study with a concentration of 5x10-5 M showed two absorption peaks at 246 nm, 354 nm, and 440 nm. The resulting fluorescence intensity of 813.1 a.u. at the wavelenght of 500 nm. The study of complex compound fluorescence shows that the addition of Cd2+ heavy metal ion can be made as fluorosensor with turn-on (enhancement) type, while the complex compound in the addition of Zn2+ heavy metal ion can be made as fluorosensor with turn off-on (quenching-enhancement) type.
Synthesis of PMCA (P-Methoxy Cinnamic Acid) using Perkin Reaction and Its Activity as Photo Protective and Antifungal Agent
Authors: Purwaningsih Yuliana , Indriyanti Erwin , Masduqi Ahmad Fuad
Published: December 2022

This study aimed to synthesize p-methoxy cinnamic acid through the Perkin reaction and to determine its activity as a photoprotective and antifungal agent against Candida albicans. The PMCA compound was synthesized by reacting p-methoxy benzaldehyde with acetic anhydride using a sodium acetate catalyst in a sonicator at 50oC for 60 minutes. The synthesized was a white precipitate with a % yield of 2.09% and a melting point of 172-175oC. ATR-FTIR identified this compound with several functional groups, C=O, OH carboxylic acid, para-substituted benzene, and C=C. Analysis by GC-MS showed a single peak at a retention time of 11.710 minutes with m/z 178. Characterization of this compound by 1H-NMR spectrometry showed several chemical shifts showing the presence of OH groups of carboxylic acids, C=C groups, aromatic benzene groups, and methoxy. The results of this characterization indicated that the synthesis product was PMCA. The antioxidant activity of PMCA using the DPPH radical gave IC50 at a concentration of 352.6138 ppm. In vitro sunscreen activity against PMCA compounds provided high protection at a concentration of 30 ppm with SPF 32,505. The antifungal activity against Candida albicans showed inhibition zones of 0.257cm± 0.044, 1.397cm± 0.093, and 1.533cm± 0.111, respectively at concentrations of 5%, 10%, and 15%. The PMCA compounds can be synthesized through the Perkin reaction assisted by ultrasonic waves and can potentially be photoprotective and antifungal agents.
The Collaboration of Padang City Government in Managing Covid-19 Disaster through The Dynamic Governance Concept
Authors: Wialdi Putri Febri , Putera Roni Ekha , Ariany Ria , Hasymi Edi
Published: December 2022

The Covid-19 pandemic has caused changes in various lives, including the administration of government as a policymaker and public service. Changes and developments in policies issued or made by the government during a pandemic need to be seen from the perspective of dynamic governance. The concept of dynamic governance is defined as how various policies, institutions, and organizational structures are selected to be able to adapt to conditions that indicate uncertainty and rapid environmental change. It is hoped that these policies, institutions, and structures will be able to be relevant and effective in meeting the needs of the community in emergency and long-term conditions. The focus of the dynamic governance concept is the uncertain future factors (uncertain conditions) that affect decision-making components such as thinking again, thinking ahead, and thinking across. In addition, there is also a lever factor in the form of able people who are capable of human resources in developing the concept of dynamic governance. Where the existence of able people in the administration of the state, especially during times of a disaster, is very influential and must be considered. This study aims to describe how the application of the concept of dynamic governance in dealing with COVID-19 in the city of Padang. This study uses qualitative methods with data collection techniques through interviews and literature study. With the results of the research, there are still variables and indicators of dynamic governance theory that have not been fulfilled, namely coordination between institutions that collaborate. So it can be concluded that it is necessary to make improvements in coordination activities to achieve a dynamic government in solving the problems of the COVID-19 pandemic in the city of Padang.
Rehabilitation procedure after surgical stabilization of the patella and cranial cruciate ligament in a dog – case study
Authors:   Department of Animal Physiology and Physiotherapy, Faculty of Animal Breeding and Biology, Bydgoszcz University of Science and Technology, Prof. Sylwestra Kaliskiego 7, 85-796 Bydgoszcz, Poland, Karasiewicz Dominika M. , Kołodziejska-Sawerska Anna ,   Department of Animal Physiology and Physiotherapy, Faculty of Animal Breeding and Biology, Bydgoszcz University of Science and Technology, Prof. Sylwestra Kaliskiego 7, 85-796 Bydgoszcz, Poland, Stanek Magdalena ,   Department of Animal Physiology and Physiotherapy, Faculty of Animal Breeding and Biology, Bydgoszcz University of Science and Technology, Prof. Sylwestra Kaliskiego 7, 85-796 Bydgoszcz, Poland
Published: December 2022

The aim of this study was to determine the effectiveness of a rehabilitation program during recovery from surgery in a dog with patellar dislocation and rupture of the cranial cruciate ligament. Manual techniques, active and passive kinesitherapy and hydrotherapy were used in the study. Parametric methods were used to evaluate the effectiveness of physiotherapy: goniometric measurements, lameness severity analysis, pelvic limb circumference measurements, and a non-parametric method: a questionnaire. The results of our study showed that physiotherapy had a positive effect on restoring normal gait and increasing muscle mass in the operated limb. The study confirmed the great usefulness of rehabilitation in the recovery process after surgical stabilization of knee joint structures. Beginning physiotherapy as soon as possible after the surgery is crucial to prevent the negative effects of limb immobilization.
CITRA DESTINASI PARIWISATA HALAL DALAM PERSPEKTIF FOTOGRAFI (STUDI KASUS DI PULAU LOMBOK)
Authors: Yuliyanto Adhi , Baiquni M , Wiyono Djoko
Published: December 2022

Abstrak

 

Penelitian ini ditujukan untuk mengetahui seberapa jauh citra destinasi pariwisata halal dalam perspektif fotografi di Lombok, Nusa Tenggara Barat. Penyajian sebuah foto harus dapat mengkomunikasikan pesan yang efektif agar pesan tersebut dapat menjangkau target wisatawan. Respon wisatawan digunakan untuk mengukur konten sebuah foto destinasi pariwisata halal dari perspektif kebutuhan wisatawan. Respon praktisi fotografi digunakan untuk membuat penyajian foto dengan teknis tertentu kepada wisatawan tentang destinasi yang dikategorikan halal dengan segala kondisi, fasilitas, kehidupan sosial dan pelayanannya. Kedua respon tersebut digunakan untuk mencari foto yang paling sesuai berdasarkan keinginan wisatawan dan ketentuan teknis fotografi untuk   kemudian dijadikan standar penciptaan dan penyajian foto untuk memperkuat               citra destinasi pariwisata halal.

 

Kata kunci: destinasi pariwisata halal, fotografi, foto destinasi pariwisata, citra destinasi pariwisata halal.

 

Abstract

 

This research is aimed to get on how the image of the image of “Halal” tourism destinations can be applied properly in photography’s perspective in Lombok, West Nusa Tenggara. Photos, which are shown, must be able to deliver an effective message in order to reach the target tourists. The tourists’ response is needed to measure the content of “Halal” tourism destinations photos from the tourist needs perspective. The photographers’ response is applied to organize the photos exhibit by particular technique to the tourists about destination that is categorized “Halal” with its condition, situation, social life, and service. Both responses are used to determine the most suitable photo based on the tourist needs and the photography technique, which is later referred as the standard of photo creation and exhibition, in order to strengthten the image of “Halal” tourism destinations.

.

 

Keywords: “Halal” tourism destinations, photography, tourism destinations photo, image of “Halal” tourism destination
Pengembangan Media Pembelajaran Video Tutorial Provide Food and Beverage Service dengan Standar KKNI Sebagai Persiapan Uji Kompetensi
Authors: Wati Syelviana , Mashabi Nurlaila Abdullah , Oktaviani Maya
Published: December 2022

PENGEMBANGAN MEDIA PEMBELAJARAN VIDEO TUTORIAL PROVIDE FOOD AND BEVERAGE SERVICE DENGAN STANDAR KKNI SEBAGAI PERSIAPAN UJI KOMPETENSI
Abstrak
Penelitian ini bertujuan untuk menghasilkan produk Video Tutorial Provide Food and Beverage Service sebagai media pembelajaran materi Food and Beverage yang sesuai standar KKNI untuk mahasiswa. Metode yang digunakan dalam penelitian ini adalah Research and Development (R&D) dengan menggunakan model ADDIE (Analyze, Design, Development, Implementation, Evaluation). Penelitian dilakukan sejak April 2020–Juni 2021. Video dikembangkan dengan Aplikasi Filmora dan memperhatikan standar KKNI. Video yang telah dikembangkan selanjutnya dilakukan validasi terhadap ahli media dan ahli materi. Dilakukan pula uji coba terhadap beberapa kelompok mahasiswa, dari mulai kelompok kecil hingga kelompok besar. Hasil penilaian Video Tutorial Provide Food and Beverage Service oleh para ahli dan mahasiswa memperoleh rata-rata keseluruhan sebesar 90%. Hasil penelitian menunjukkan bahwa pengembangan media Video Tutorial Provide Food and Beverage Service dapat digunakan mahasiswa sebagai persiapan uji kompetensi yang sesuai standar KKNI.
Kata kunci: food and beverage service, standar KKNI, karya inovatif.
DEVELOPMENT OF VIDEO TUTORIAL PROVIDE FOOD AND BEVERAGE SERVICE LEARNING MEDIA WITH KKNI STANDARDS AS COMPETENCY TEST PREPARATION
Abstract
This research and development is intended to produce Video Tutorial Provide Food and Beverage Service as a learning medium for Food and Beverage materials that are in accordance with KKNI standards for college students. The method used in this research is Research and Development (R&D) using the ADDIE model (Analyze, Design, Development, Implementation, Evaluation). The research was conducted from April 2020–July 2021. The video was developed with (the application) and took into account the IQF standard. The videos that have been developed are then validated against media experts and material experts. Experiments were also conducted on several groups of students, from small groups to large groups. The results of the Provide Food and Beverage Service Video Tutorial assessment by experts and students obtained an overall average of 90%. The results showed that the development of the Provide Food and Beverage Service Video Tutorial media could be used by students as preparation for a competency test according to KKNI standards.
Keywords: food and beverage service, KKNI standards, innovative work.
PENGEMBANGAN MEDIA PEMBELAJARAN PENANGANAN RESERVASI HOTEL BERBASIS VIDEO MOTION GRAPHIC DI SMK AKOMODASI PERHOTELAN
Authors: Yusuf Shofa Fithriturrohmi
Published: December 2022

Penelitian ini didasari oleh banyaknya tuntutan pembelajaran pada mata pelajaran reservasi membuat peserta didik sulit untuk memahami materi jika hanya mengandalkan buku teks sebagai sumber belajar. Buku teks tidak dapat menunjukan tahapan praktik reservasi secara langsung. Sementara, peserta didik SMK dituntut untuk memahami praktik reservasi secara langsung. Untuk itu diperlukan media pembelajaran yang sejatinya dapat mengatasi keterbatasan dan memberikan pembelajaran yang efektif dan efisien untuk mencapai tujuan pembelajaran. Didukung dengan pesatnya perkembangan teknologi digital untuk meningkatkan kualitas kegiatan belajar mengajar berbasiskan teknologi di SMK, pada penelitian ini memberikan pembaharuan pada media pembelajajaran berupa video animasi yang disebut dengan video motion graphic. Tujuan penelitian ini yaitu untuk mengembangkan media pembelajaran penanganan reservasi hotel berbasis video motion graphic di SMK akomodasi Perhotelan. Penelitian ini menggunakan metode Research and Development (R&D) dengan model planning, production, and evaluation (PPE). Teknik pengumpulan data dilakukan dengan wawancara dan expert judgement oleh dua orang ahli materi dan dua orang ahli media. Hasil temuan penelitian yang diperoleh dari hasil expert judgement menunjukkan bahwa media pembelajaran penanganan reservasi hotel berbasis video motion graphic berada pada kriteria sangat layak, baik dari segi materi maupun media, sehingga dapat digunakan oleh guru untuk kegiatan belajar mengajar
STRATEGI PEMASARAN PAKET WISATA ALAM AIR TERJUN BENANG KELAMBU PT. LIRIK LOMBOK TOURS DI MASA PANDEMI COVID-19
Authors: Baiqoh Roh Helmi Oktaria  , Hizmi Surayyal , Yakin Ainul
Published: December 2022

Tujuan penelitian: Penelitian  ini  bertujuan  untuk  mengetahui  Startegi  Pemasaran  Paket Wisata khuasnya Paket Wisata Benang Kelambu PT. Lirik Lombok Tours di masa pandemi Covid-19 menggunakan bauran pemasaran 7P, dari ketujuh bauran pemasaran  tersebut  peneliti  memfokuskan  empat  bauran  pemasaran  saja yaitu Produk, Harga, Tempat (Place) & Promosi (Promotion).

Metode penelitian: Penelitian ini merupakan penelitian deskriptif kualitatif. Teknik pengumpulan data melalui observasi, wawancara dan dokumentasi yang kemudian dianalisis dengan melihat faktor bauran pemasaran. Keempat bauran pemasaran tersebut kemudian dihubungkan dengan aspek atraksi, amenitas, aksesibilitas dan aktivitas yang tersedia pada Air Terjun Benang Kelambu.

Hasil dan pembahasan: Hasil dari penelitian ini menunjukkan bahwa strategi pemasaran Paket Wisata Alam Air Terjun Benang Kelambu PT. Lirik Lombok Tours di masa pandemi Covid-19 sangat berpengaruh besar terhadap pendapatan agen perjalanan maupun destinasi wisata. Ditinjau dari teori bauran pemasaran produk yang berkaitan dengan unsur Atraksi, Aktivitas, Amenitas, Aksesibilitas & Akomodasi terdapat beberapa kendala pada bagian amenitas atau fasilitas pendukung lain yang masih sangat kurang yang mempengaruhi pemasaran paket wisata tersebut.

Aplikasi: Travel agent perlu mengkonfirmasi ketersediaan fasilitas pendukung pada destinasi wisata yang dipasarkan sehingga tidak merdampak pada kurangnya minat wisatawan berkunjung.
PENYIAPAN KAMAR TAMU DI JM HOTEL DESA KUTA LOMBOK TENGAH
Authors: Muliadi Samsul , Hizmi Surayyal , Husni Muhammad
Published: December 2022

Tujuan penelitian: Penelitian ini  bertujuan  untuk  mengetahui  persepsi dan pengetahuan dari karyawan pada JM Hotel terhadap pelaksanaan penyiapan kamar tamu yang sesuai dengan SOP yang dimiliki oleh hotel tersebut.

Metode penelitian: Penelitian ini menggunakan metode kualitatif dengan mewawancarai karyawan untuk memperoleh data terkait pemahaman dan persepsi karyawan terhadap penerapan dan pelaksanaan SOP penyiapan kamar. Data yang diperoleh kemudian didukung oleh hasil observasi langsung terhadap karyawan divisi housekeeping dalam menyiapkan kamar tamu.

Hasil dan pembahasan: Berdasarkan dari hasil wawancara ditemukan bahwa seluruh karyawan pada JM Hotel menyatakan pentingnya melaksanakan set-up kamar yang sesuai dengan SOP demi memberikan kenyaman pada tamu. Sedangkan hasil observasi menunjukkan adanya perbedaan dalam urutan SOP yang dilakukan dengan standar ASEAN Toolbox atau pun salah satu hotel berbintang.

Aplikasi: Perlu adanya pengembangan dan sosialisasi lebih lanjut terhadap karyawan hotel terkait pelaksanaan SOP yang sesuai dengan standar ASEAN Toolbox demi peningkatan kualitas pelayanan dari hotel tersebut.
STRATEGI PEMASARAN VIRTUAL TOUR DI MASA PANDEMI
Authors: Hamid Abdul , Hizmi Surayyal , Supardi
Published: December 2022

Tujuan penelitian: Covid-19 menyebabkan banyak destinasi wisata terpaksa harus ditutup sehingga masyarakat tidak dapat melakukan perjalanan wisata, hal ini mempengaruhi penghasilan bagi perushaan travel khusunya di Lombok. Melihat hal tersebut virtual tour menjadi solusi tour di masa pandemi, khususnya pada Lombok Hidden Trip.

Metode penelitian: pendekan yang digunakan adalah diskriptif kualitatif dengan menggunakan teknik pengumpulan data yaitu observasi, wawancara dan dokumentasi, yang kemudian hasilnya dianalisis dengan menggunakan anaslisi SWOT.

Hasil dan pembahasan: Beberapa strategi yang digunakan Lombok Hidden Trip dalam memasarkan virtual tournya yaitu dengan cara meningkatkan inovasi dalam produk dan mengembangkan strategi promosi kemudian merekrut team ahli dalam vidiographer sehingga mampu berkretifitas dan menghasilkan virtual tour yang menarik sehingga virtual tour dapat menjadi opsi tour bagi banyak orang.

Aplikasi: Penambahan media promosi pada media sosial dan membuat variasi promosi dengan menggunakan beberapa media menarik seperti video dapat menjadi solusi agar promosi paket wisata tidak monoton dan dapat menarik perhatian berbagai target pasar.
Powtoon Pengembangan Media Pembelajaran Video Animasi Dengan Powtoon Mata Pelajaran Laundry Di SMK 32 Jakarta
Authors: Dania Rahmawati Dania , Mulyati Mulyati
Published: December 2022

Penelitian ini bertujuan mengetahui Pengembangan Media Pembelajaran Video Animasi Dengan Powtoon Mata Pelajaran Laundry di SMK 32 Jakarta. Pengumpulan data dengan diberikannya angket atau kuesioner kepada ahli media, ahli materi dan responden sebanyak 21 orang. Poin penilaian menggunakan Skala Likert 1-5. Pengembangan media pembelajaran video animasi dengan Powtoon menggunakan metode Research and Development (RnD) dengan model pengembangan Lee and Owens (2004) yaitu Analyze, Design, Development, Impelementation, and Evaluation. Hasil validasi oleh ahli materi mendapatkan nilai rata – rata sebesar 4,7 sedangkan hasil ahli media mendapatkan data sebesar 4,9, lalu hasil uji lapangan perorangan sebesar 4,7 dengan kategori Sangat Baik pada aspek kelayakan media dan aspek penyajian materi sebesar 4,8 dengan kategori sangat baik, sedangkan uji coba terbatas pada aspek media mendapatkan data sebesar 4,5 dengan kategori Sangat baik dan pada aspek penyajian materi mendapatkan data sebesar 4,8  dan terakhir uji lapangan sebanyak 15 orang menunjukkan sebesar 4,2 dengan kategori Sangat Baik.
Анализ динамики эпидемического процесса COVID-19 в мире за неделю с 10.12.2022 г. по 16.12.2022 г.
Authors: Зимирова Анастасия , Поспелов Михаил , Иванова Александра , Дмитриева Людмила , Чумачкова Елена , Карнаухов Игорь , Щербакова Светлана , Кутырев Владимир
Published: December 2022

В обзоре представлен анализ эпидемиологической ситуации в странах мира по COVID-19, за неделю с 10.12.2022 г. по 16.12.2022 г.
Suboptimal Health Status Measurement Instruments: A Systematic Review Protocol
Authors: Asweto Collins Otieno , Hassan Sehar-un-Nisa , Alzain Mohamed Ali
Published: December 2022

Background: There is high burden of chronic diseases in Saudi Arabia. It is therefore paramount to identifying at-risk population to prevent the chronic disease and provide personalized primary healthcare. The at-risk population can easily be identify by conducting Suboptimal Health Status (SHS) assessment. Consequently, there is need to determine a suitable validated Suboptimal Health Status (SHS) tool for identifying these people in Saudi Arabia.
Objective: To systematically review valid measures of SHS, critique the utility and their attributes.
Methods: This review will adopt Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) and Centre for Reviews and Dissemination guide. A systematic search will be done in PubMed, CINAHL, SCOPUS, Web of Science CORE, and Consensus-based Standards to the selection of Health Measurement Instruments database. The search approach will follow the Peer Review of Electronic Search strategy recommendations. Studies specifically aiming to assess SHS within the context of well-being and illness will be involved. Data Extraction Form will standardize the information recorded and aid analyses. The Consensus-based Standards for the Selection of Health Measurement Instruments (COSMIN) checklist will be applied to appraise the procedural rigor and results of the instruments.
Expected results: The projected outcome is identification of a reliable and valid SHS tool.
Registered in PROSPERO 2021 ID: CRD42021290565
Reovirus combined with a STING agonist enhances anti-tumor immunity in a mouse model of colorectal cancer
Authors: Kubota Eiji , Sugimura Naomi , Mori Yoshinori , Aoyama Mineyoshi , Tanaka Mamoru , Shimura Takaya , Tanida Satoshi , Johnston Randal , Kataoka Hiromi
Published: December 2022

Reovirus, a naturally occurring oncolytic virus, initiates the lysis of tumor cells while simultaneously releasing tumor antigens or proapoptotic cytokines in the tumor microenvironment to augment anticancer immunity. However, reovirus has developed a strategy to evade antiviral immunity via its inhibitory effect on interferon production, which negatively affects the induction of antitumor immune responses. The mammalian adaptor protein Stimulator of Interferon Genes (STING) was identified as a key regulator that orchestrates immune responses by sensing cytosolic DNA derived from pathogens or tumors, resulting in the production of type I interferon. Recent studies reported the role of STING in innate immune responses to RNA viruses leading to the restriction of RNA virus replication. In the current study, we found that reovirus had a reciprocal reaction with a STING agonist regarding type I interferon responses in vitro; however, we found that the combination of reovirus and STING agonist enhanced anti-tumor immunity by enhancing cytotoxic T cell trafficking into tumors, leading to significant tumor regression and survival benefit in a syngeneic colorectal cancer model. Our data indicate the combination of reovirus and a STING agonist to enhance inflammation in the tumor microenvironment might be a strategy to improve oncolytic reovirus immunotherapy.
Adaptive robust control of unmanned tracked vehicles for trajectory tracking based on constraint modeling and analysis
Authors: Wang Xiuye , Wang Yinlong , Sun Qinqin , Chen Yu , Al-Zahrani Ahmed
Published: December 2022

A novel trajectory tracking control problem based on constraint modeling and analysis is addressed by the way of constraint-following control for the unmanned tracked vehicle in this paper. The unmanned tracked vehicle system contains time-varying uncertainty which is possibly swift but bounded, and the bound is possibly unknown. First, the coupled dynamics model of unmanned tracked vehicle is established. By taking into account the kinematic characteristics, it makes the motion control of unmanned tracked vehicles more precise. Meanwhile, a 3D virtual prototype model is established for the unmanned tracked vehicle. Second, for the control objective of trajectory tracking, the related problem is converted into a constraint-following problem, and an adaptive robust control is therefore proposed based on this for the controlled unmanned tracked vehicle system to satisfy the trajectory tracking constraint. Finally, it is proved that the controlled unmanned tracked vehicle system can achieve accurate trajectory tracking with the proposed adaptive robust control, even under the interference of complex time-varying uncertainties. Modeling accurate dynamics and trajectory tracking constraints for unmanned tracked vehicles and designing an adaptive robust controller to realize accurate motion control for unmanned tracked vehicles even under strong external disturbances are the main contributions of this paper.
Cesarean section and the risk of allergic rhinitis in children: A systematic review and meta-analysis
Authors: Liu Zixin , Zhou Yaqian , Chen JunRong , Liu Xiaohua , Xie Li , Zhang Jialin , Su Honghui , Yang Yide , Tian Mei , Dong Yunpeng , Li Jian
Published: December 2022

Background
Multiple evidence indicates that perinatal factors make impact on immune development and affect offspring allergic rhinitis(AR) risk. In this systematic review and meta-analysis, we examined available published studies to clarify the relationship between cesarean section(C-section) and offspring AR in children.
Objective
To explore the relationship between C-section, especially the special attention was paid to different cesarean delivery method, and the risk of AR in children.
Methods
Articles were searched using PubMed, Web of Science, EMBASE, Cochrane Library, China knowledge Network, Wanfang, and China Science and Technology Journal databases. A meta-analysis of 22 studies published before August 1, 2022, which included 1,464,868 participants, was conducted for statistical analysis with RevMan5.4. The correlation strength between C-section and offspring AR was determined by combining odds ratio(OR) and 95% confidence interval(95%CI). Publication bias was detected using the funnel chart and Begg’s tests.
Results
Meta-analysis revealed that there was a significant correlation between C-section and children AR (OR = 1.19, 95% CI:1.12–1.27, P < 0.001), especially C-section with a family history of allergy (OR = 1.82, 95%CI:1.36–2.43, P < 0.001). Moreover, elective C-section (without genital tract microbe exposure) had the higher risk of offspring AR (OR = 1.24, 95%CI:1.05–1.46, P = 0.010) compared with the whole study.
Conclusions
Delivery by C-section, particularly elective C-section and C-section with a family history of allergy can increase the risk of AR in children.
Machine Learning for Annotating Sparsely Labeled Biocide and Metallotoxin Resistance Genes Using Natural Language Processing Techniques
Authors: Ananey-Obiri Daniel , Rhinehardt Kristen
Published: December 2022

Background
The importance of non-antibiotic drugs such as metallic and biocide antimicrobials in the progression of antibiotic resistance in bacteria cannot be oversimplified. Through co-selection, they have been implicated as agents for the promotion of antibiotic resistance in bacteria. Plethora of literature has explored antibiotic resistance, but the same cannot be said of non-antibiotic antimicrobials such as metals and biocide in spite of the important role they play in this phenomenon. It is also a common knowledge that most biological sequence data are either wrongly labeled or without labels. The manual annotation of these data by human are time consuming, expensive, and prone to errors. The recent upsurge in machine learning applications promises a viable solution. Traditional machine learning approaches rely on heavily labeled samples to build models for predictions. However, machine learning methods such as semi-supervised learning (SSL) models can overcome the shortfalls in data labeling when few labeled samples are available.
Results
Here, we developed different SSL methods to annotate and identify biocide and metallotoxin resistance genes. We represent protein sequences as vectors developed using Word2vec and Global vectors (GloVe) word vectors. We simulated real-world scenarios by varying the number of samples from 5 to 30% and measured their performance on the two datasets. Our findings show that SSL methods are viable solution in annotating sparsely labeled genomic sequence data. SSL with fewer available sequences outperformed some supervised learning models.
Conclusion
The findings from this study indicate that we can use machine learning models with fewer labeled samples (5%) to annotate biological sequences. Also, non-antibiotic resistance genes can be identified with machine learning models with high accuracies.
Factors Influencing the Effectiveness of Logistics Management Information Systems on Drugs Supply Chain Management in Sierra Leone
Authors: Kamara Lamin , Kalinga Ellen Ambakisye Chale
Published: December 2022

Background: Logistics Management Information System (LMIS) was introduced in Sierra Leone to improve drug supply management and provide accurate information that can be used for planning and resources allocation. The system managed drugs supplies, but this system is being influenced by factors to enhance effective drugs supply management.
Methodology: The study examined factors considered to influence LMIS effectiveness on drugs supplies management, using the conceptual framework model. Purposive and sequential exploratory means of data collection through self-administered questionnaires was employed.
Results: The study identified eleven factors and only four (Forecasting, Logistics, Information Quality and Production) have significant influence on LMIS effectiveness on drugs supply management.
Conclusion:The study showed four factors having positive and statistically significant effect on LMIS effectiveness on drugs supply management. Therefore, strengthening these factors would significantly improve LMIS effectiveness on drugs supply management in Sierra Leone.
A treatment planning system for manifold multi-ion particle therapy
Authors: Alabd Roumani , Bishop Adrian N. , Safavi-Naeini Mitra , Chacon Andrew , Franklin Daniel R.
Published: December 2022

This paper reports on the design of an open source treatment planning system for optimal multi-ion irradiation of a heterogeneous target with arbitrary spatial dose distributions. The developed TPS features controllable avoidance of dose in organs at risk and optional linear energy transfer enhancement in hypoxic target sub-volumes. The performance of the treatment planning system is evaluated under a variety of conditions in a heterogeneous target to demonstrate the dose uniformity and conformance benefits of treatment achievable with manifold multi-ion therapy versus single-ion or dual-ion therapy.
Creating an Inexpensive PVC Knee Model for the Training of Ultrasound-Guided Medial Intra-Articular Knee Injections
Authors: McDermott Ryland , Melanson Joshua , Davidson Skylar , Doyle Nora
Published: December 2022

Objectives
Ultrasound (US)-guided injections using corticosteroids or platelet-rich plasma into the knee joint are commonly used for conservative treatment of knee pathology. Practitioner skill acquisition can be challenging due to expensive simulation models and desire to limit practice on live patients. We sought to create an inexpensive, accurate educational prototype for intra-articular knee injections.
Methods
Two polyvinyl chloride (PVC) pipes were used for the skeletal infrastructure with a detergent pod placed in between the PVC pipes to replicate the joint space. Layers of undercooked bacon simulated the hyperechoic medial collateral ligament and hypoechoic subcutaneous tissue. The total model cost was $6.88.
Results
Our PVC model simulated anatomical landmarks and was validated through comparison to standardized educational US training videos. The model was successfully recreated 10 times. Furthermore, the PVC model was able to facilitate intra-articular knee injections by penetrating through the superficial structures of the model and injecting into the detergent pod. The model was used to facilitate injections under US guidance with 24 different medical student practitioners across 4 different educational sessions. We further validated our model with US experts.
Conclusions
Our knee model was successful in replicating medial, intra-articular knee injections under US guidance. It provided accurate injection practice as it simulated realistic bony landmarks and soft tissue. Because our model is inexpensive and easy to make, many more learners in the medical field can now safely and easily practice this procedure.
Correlation Between Maternal Subclinical hypothyroidism and Intelligence and Movement Skills of Offspring at 1 Years of Age
Authors: zhang xiaomei , yuan ning , sun jianbin , zhao dan , xu xiumei
Published: December 2022

Background:Maternal subclinical hypothyroidism (SCH) maybe impact development intelligence and movement skills of offspring. Therefore, the purpose of this study is to investigate the correlation between maternal SCH and offspring intelligence and movement skills on the 2017 American Thyroid Association diagnostic criteria. Methods: This was a two-way cohort study involving 185 women and their offspring within 1 year after delivery. There were 40 women and their offspring in the SCH group and 100 women and their offspring in the euthyroid (ET) group. The general condition and thyroid function of pregnant women and the condition of offspring at birth were recorded. At the age of 1 year, the offspring were scored with the Bailey infant development scale, including intelligence score and motor score.Results:There were no significant differences in maternal and child characteristics, birth weight and gestational age between SCH group and ET group. The mental development index (MDI) and psychomotor development index (PDI) levels in ET group were higher than that in SCH group [121(112,130)vs 114(108,128), P<0.05; 118(108,131)vs 113(101,127), P＜0.05.]. Multivariate logistic regression showed SCH during pregnancy was not associated with abnormal of intelligence and movement skills of offspring at 1 years of age (MDI OR, 0.112 95%CI, 0.012-1.359; PDI OR, 0.107 95%CI, 0.007-1.557).Conclusions:After levothyroxine treatment in the first trimester of pregnancy, there was no significant difference in the incidence of intellectual and motor developmental abnormalities of offspring at 1 years of age between the SCH group and ET group, however, the overall score of offspring in SCH group was still lower than that in ET group. Numerous studies are needed to further explore the correlation between SCH and offspring intelligence and movement skills.
Spatial and seasonal variation of Microplastics in the Avoimitro Ghat and Kalurghat of the Karnaphuli River, Chattogram
Authors: Shimul Shahida Arfine , Bakeya Zannatul , Rana Saifuddin , Ananna Jannatun Naeem , Nahid Sk. Ahmad Al
Published: December 2022

The study investigated the Microplastics (MPs) abundance in the two distinct locations (Avoimitroghat and Kalurghat) of the Karnaphuli River, Chattogram, Bangladesh. Eight samples were collected monthly throughout the study period, with three transects covering a total area of 500 m at each site. MPs were collected using a 200 μm mesh size manta net, separated through a density separator, enumerated, and characterized using a microscope. Avoimitro Ghat (94861 ± 97126) had a higher mean abundance of MPs (particles per Km2) than Kalurghat (31343 ± 33183). Statistically significant variation was observed (p < 0.05) in the mean abundance of MPs per km2 between the rainy (76134 ± 89641) and dry (63101 ± 79174) seasons. Fragment group MPs had the highest mean abundance (117430 ± 105028 MPs/Km2), whereas pellets had the lowest (8264± 8637). MPs with an elongated shape were dominant at both stations and during all seasons. Blue MPs had the highest mean item value in Avoimitro Ghat and during the dry season, while brown-colored MPs were highest in Kalurghat and during the rainy season. Among the five different size groups, 1–2 mm MPs were abundant in both seasons and Avoimitro Ghat, whereas 500 µm to < 1 mm MPs were abundant at the Kalurghat stations. This study identified and quantified microplastics at the chosen sites, which will be helpful for stakeholders in mitigating microplastic pollution in the Karnaphuli River.
Point of care Thoracic Ultrasound vs. Chest Computed Tomography in the approach of Febrile Neutropenia patients
Authors: Rendon-Ramirez Erick J. , Treviño-Garcia Karla Belen , Peña-Lozano Samantha P. , Treviño Mario Alonso , Mercado-Longoria Roberto , Nañez-Terreros Homero , Salinas-Chapa Matias , Gómez-Almaguer David , Cantú-Rodriguez Olga G. , Cedillo-Huerta Hector Enrique , Colunga-Pedraza Perla R.
Published: December 2022

Purpose: Our study aimed to evaluate the correlation between CT and Thoracic Ultrasound (TUS) in detecting pulmonary pathology in immunosuppressed patients.
Methods: A single center prospective study was conducted. Consecutive patients with febrile neutropenia who underwent CT underwent TUS evaluation within 24h after CT. Both studies were performed by an expert who was blinded to the clinical information and results of the alternative imaging modalities.
Results: 34 patients met the eligibility criteria. The median age was 39.9 years (±17 SD). TUS as a diagnostic test had a sensitivity of 92.9% and specificity of 83.3%, negative predictive value (NPV) of 71.4%, and positive predictive value of 96.3%. Good concordance was demonstrated with a kappa of 0.71 (p = 0.001) between the TUS and chest CT findings. We obtained a kappa of 1 (p = 0.001) for the final diagnosis of Pleural Effusion (PE).
Conclusion: TUS is a promising screening test for immunocompromised individuals. The results showed a good correlation between CT and TUS diagnoses for the detection of pulmonary findings and high sensitivity.
The relationship between body composition and the growth hormone/insulin-like growth factor-1 axis in children and adolescents with short stature
Authors: Hou Yue , Liu Fupeng , Yang Qing , Zhang Hongli , Ban Bo , Zhang Mei , Zhang Yanhong , Gao Ting , Zhou Xusheng , Li Yanying
Published: December 2022

This study aimed to investigate the relationship between body composition and the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis in children and adolescents with short stature. All participants underwent a bioelectrical impedance analysis (BIA) and growth hormone stimulation tests, and their percentage of body fat (PBF), fat mass index (FMI), free fat mass index (FFMI), and skeletal muscle index (SMI) were calculated. The study included 310 individuals aged 10.19 ± 3.24 years, with height standard deviation score (SDS) of − 2.44 ± 0.56 and the mean peak of GH was 7.20 ± 5.11 ng/mL. Pearson analysis demonstrated that peak GH value negatively correlated with PBF and FMI. Contrastingly, IGF-1 SDS was positively correlated with FFMI and SMI. Multiple linear regression analysis showed that GH peak and IGF-1 SDS were independent predictors of PBF/FMI and FFMI/SMI, respectively. Serum GH and IGF-1 SDS were associated with body fat and lean body weight, respectively.
Band gap of Fayalite for 5% Laterite Soil and Iron Sand Analysis from Theoretical Calculation of Kubelka–Munk equation, Taylor expansion, and Self-Consistent Field Method
Authors: Heryanto Heryanto , Tahir Dahlang
Published: December 2022

In this study, the fayalite structure is extracted from nickel slag and band gap modification is achieved by added with laterite soil and iron sand. We propose a precise estimation of the band gap using the Kubelka-Munk equation, aided by the Taylor expansion simulation, and show results for generalized gradient approximation and ab-initio. We successfully demonstrated that the combination of Tauc’s plots, Tauc’s plots with Taylor expansion, and self-consistent field methods is the most accurate way to measure the energy between the valence and conduction bands (band gap). In addition, we found an excellent correlation between an increase in the crystallinity index and a decrease in the crystallite size in relation to a decrease in the band gap.
Morphological and molecular identification of Callithrix sp. hybrids
Authors: Santos Bruna Mendonça , Aleixo Talita Roberto , Rodrigues Larissa Pereira , Nogueira Pedro Paulo Oliveira , Felippi Daniel Angelo , Mota Lígia Souza Lima Silveira da
Published: December 2022

The Common marmoset (Callithrix jacchus) and Black-tufted marmoset (Callithrix penicillata) are endemic species in the Northeast, East Central and part of the Northeast, respectively in Brazil. Currently, both species are distributed in different regions of the country, being the main cause the illegal trafficking. The introduction of exotic animals is the second biggest cause of biodiversity loss globally and can lead to hybridization. In Bauru, São Paulo (SP), there is a record of both species and animals showing intermediate patterns between them. Thus, this work aimed to identify individuals of the genus Callithrix present in The Municipal Botanical Garden of Bauru (MBGB) as either pure or hybrids, through morphological and molecular markers. Ten individuals were sampled, 4 of which were pure species for control and six free-living, which were photographed, morphometrically measured, and from which the fragments of the mitochondrial genes COI and D-loop region were amplified. As a result, all animals showed intermediate patterns between both species. After analyzing the sequences obtained for D-loop and obtaining a high haplotypic diversity (h), low nucleotide diversity (π), Tajima D and Fu’s Fs statistic, it is possible to infer that the animals in the area continue receiving gene flow and the population began from a founder effect. Morphological and molecular data indicate that the individuals sampled are hybrids. From the data generated by this research, it is possible to plan the insertion of management of these animals in the Conservation Unit (UC), to avoid population growth and its outcomes.