bluuebunny/crossref_metadata_2025 huggingface dataset:
Study on the Prediction of Launcher Efficiency of Electromagnetic Launcher Based on Particle Swarm Optimization-Improved BP Neural Network
Authors: Xiao Nan , Li Jun , Yan Ping
Published: September 2024

Launcher efficiency is an important index for evaluating the performance of the electromagnetic launcher, and it reflects the ability of the launcher to convert input electrical energy into kinetic energy of the armature. In this paper, the launcher efficiency is taken as the objective function of bore parameter optimization, and particle swarm optimization is used to optimize the initial parameters of the BP neural network to improve the accuracy of the neural network in predicting launcher efficiency. The results show the following: (1) The predicted efficiency of the launcher shows the same trend as the experimental results. When the ratio of rail separation and rail height is greater than 1.75, the rate of change in the launcher efficiency curve decreases as the rail separation increases. (2) The weight of the influence of each parameter on the launcher efficiency follows the following law: convex arc height > rail separation > rail height > rail thickness. (3) The mean absolute error of the BP neural network prediction is 0.70%; after optimization by PSO, the mean absolute error is reduced to 0.28% and the mean relative accuracy is improved from 0.9774 to 0.9910, which indicates the feasibility of the PSO-BP neural network for the prediction of the launcher efficiency of an electromagnetic launcher.
Quantification and Categorization of Macroplastics (Plastic Debris) within a Headwaters Basin in Western North Carolina, USA: Implications to the Potential Impacts of Plastic Pollution on Biota
Authors: Barrett Nathaniel , Miller Jerry , Orbock-Miller Suzanne
Published: September 2024

Plastic production on a commercial scale began in the 1950s, reaching an annual production of 460 million metric tons in 2019. The global release of 22% of produced plastics into the environment has raised concerns about their potential environmental impacts, particularly on aquatic ecosystems. Here, we quantify and categorize plastic debris found along Richland Creek, a small, heavily forested watershed in western North Carolina, USA. Plastics within the riparian zone of seven 50 m reaches of Richland Creek and its tributaries were sampled two or three times. The 1737 pieces of collected plastic debris were returned to the lab where they were measured and categorized. A small-scale laboratory study using seven of the items collected was performed to determine their ability to break down into microplastics (particles < 5 mm in size). The majority (76%) of collected items were made of either plastic film (particularly bags and food wrappers, 43%) or hard plastics (e.g., bottles, 2%). However, when viewed on a surface area basis, films and synthetic fabrics (e.g., clothing, sleeping bags) equally dominated. Roughly three-quarters of the items collected had a width less than 10 cm, due primarily to the fragmentation of the original items; over two-thirds of the collected items were fragmented. Items composed of foams and films exhibited the highest fragmentation rates, 93% and 86%, respectively. Most collected plastics were domestic in nature, and the number of items increased downstream through more developed areas. Laboratory studies showed that plastic debris has a propensity to break down into microplastics. We believe the data collected here should be replicated in other streams, as these freshwater environments are the source of plastics that eventually enter the oceans.
Heavy Nitrogen Application Rate and Long-Term Duration Decrease the Soil Organic Carbon and Nitrogen Sequestration Rates in Forest Ecosystems
Authors: Yang Yulian , Yang Jiaping , Dong Qing , Li Dehui , Tan Bo , Wu Qinggui , Xu Zhenfeng , Xu Hongwei
Published: September 2024

Nitrogen addition alters soil organic carbon (SOC) and total nitrogen (TN) accumulation in forest ecosystems, but the responses of SOC and TN sequestration rates and dynamics to nitrogen addition in forest ecosystems worldwide remain unclear. This study conducted a global analysis to evaluate the effects of the nitrogen application rate, nitrogen addition duration (time), and humidity on the SOC and TN accumulation rates from 257 data points (63 articles). Nitrogen addition increased SOC and TN by 4.48% and 10.18%, respectively. The SOC and TN accumulation rates were 0.65 and 0.11 g kg−1 yr−1, respectively. Moreover, the percentage changes of SOC and TN overall increased with the nitrogen application rate and duration of nitrogen addition; however, the accumulation rates of SOC and TN overall decreased with the nitrogen application rate and the duration of nitrogen addition. In addition, the percentage changes and change rates of SOC and TN increased overall with the humidity index. In conclusion, nitrogen addition promoted SOC and TN accumulation in forest soil, and the nitrogen application rate and nitrogen addition duration increased the percentage changes in SOC and TN; however, they decreased the accumulation rate, whereas humidity increased the accumulation rates of SOC and TN. These results enhance our understanding of soil carbon and nitrogen cycling in forest soils in the context of global nitrogen deposition.
An Examination of the Antennal Sensilla of the Oligophagous Moth Species Dioryctria sylvestrella (Lepidoptera: Pyralidae)
Authors: Wang Qi , Ma Yujia , Jiang Dun , Yan Shanchun
Published: September 2024

Dioryctria sylvestrella (Lepidoptera: Pyralidae) is a destructive borer pest on Korean pine (Pinus koraiensis) indigenous to northeastern China. The antennal sensilla of D. sylvestrella were examined by scanning electron microscopy to understand the behavioral ecology of this insect pest. Both the male and female antennae are filiform, and each consists of a scape, a pedicel, and a flagellum. D. sylvestrella is characterized by sexual dimorphism. Only the male antennae present two deeply grooved thumblike protuberances on the crest surfaces of their fourth and fifth flagellomeres, respectively. These structures have never been reported for any other Pyralidae. Eight different types of sensilla with unique bioecological functions were detected on the antennae of both sexes. There may be structure–location–function relationships for these sensilla, and most of them are involved in communication between the insect and the host plant, mate detection, and oviposition site selection.
Wireless Wave Attenuation in Forests: An Overview of Models
Authors: Ma Yuewei , Li Wenbin , Han Dongtao , He Yuan , Li Qingsong , Bai Xiaopeng , Xu Daochun
Published: September 2024

In recent years, the need for reliable signal transmission in forested areas has increasingly grown, and the past few decades have witnessed significant developments in related research. With the emergence of smart forestry and precision forestry, understanding the science behind enhancing signal reliability in forests—specifically, studying the patterns and models of radio wave attenuation in these environments—has become crucial. To this end, we conducted a comprehensive review based on bibliometrics to summarize and construct the existing academic literature, revealing current research trends and hotspots. Utilizing bibliometric techniques, we analyzed the literature on radio wave attenuation in forests to summarize and evaluate previous studies. Our analysis indicates that empirical models (67%), hybrid models (21%), and equivalent models (12%) are the three main research clusters in this field. We observed that studies on radio attenuation are more prevalent in urban and artificial forests, while there is a scarcity of research in complex conditions like tropical rainforests and extreme weather; studies are more focused on UHF, VHF, and SHF frequency bands, with lesser attention given to other bands. Previous research has not adequately considered the impact of seasonal factors on signal attenuation patterns nor the influence of forest working environments.
Performance Properties and Finite Element Modelling of Forest-Based Bionanomaterials/Activated Carbon Composite Film for Sustainable Future
Authors: Zor Mustafa , Şen Ferhat , Özçelik Orhan , Yazıcı Hikmet , Candan Zeki
Published: September 2024

Thanks to its highly crystalline structure and excellent thermal, optical, electrical and mechanical properties, carbon and its derivatives are considered the preferred reinforcement material in composites used in many industrial applications, especially in the forest and forest products sector, including oil, gas and aviation. Since hydroxyethyl cellulose (HEC) is a biopolymer, it has poor mechanical and thermal properties. These properties need to be strengthened with various additives. This study aims to improve the thermal and mechanical properties of hydroxyethyl cellulose by preparing hydroxyethyl cellulose/activated carbon (HEC/AC) composite materials. With this study, composites were obtained for the first time and their mechanical properties were examined using a 3D numerical modeling technique. The thermal stability of the prepared composite materials was investigated via thermal gravimetric analysis (TGA). The samples were heated from 30 °C to 750 °C with a heating rate of 10 °C/min under a nitrogen atmosphere and their masses were measured subsequently. The mechanical properties of the composites were investigated via the tensile test. The viscoelastic properties of the composite films were determined with dynamic mechanical thermal analyses (DMTA) and their morphologies were examined with scanning electron microscopy (SEM) images. According to the results, the best F3 sample (films containing 3 wt.% activated carbon) had an elastic modulus of 168.3 MPa, a thermal conductivity value of 0.068 W/mK, the maximum mass loss was at 328.20 °C and the initial storage modulus at 30 °C was 206.13 MPa. It was determined that the hydroxyethyl cellulose composite films containing 3 wt.% activated carbon revealed the optimum results in terms of both thermal conductivity and viscoelastic response and showed that the obtained composite films could be used in industrial applications where thermal conductivity was required.
Edge Computing in Healthcare: Innovations, Opportunities, and Challenges
Authors: Rancea Alexandru , Anghel Ionut , Cioara Tudor
Published: September 2024

Edge computing promising a vision of processing data close to its generation point, reducing latency and bandwidth usage compared with traditional cloud computing architectures, has attracted significant attention lately. The integration of edge computing in modern systems takes advantage of Internet of Things (IoT) devices and can potentially improve the systems’ performance, scalability, privacy, and security with applications in different domains. In the healthcare domain, modern IoT devices can nowadays be used to gather vital parameters and information that can be fed to edge Artificial Intelligence (AI) techniques able to offer precious insights and support to healthcare professionals. However, issues regarding data privacy and security, AI optimization, and computational offloading at the edge pose challenges to the adoption of edge AI. This paper aims to explore the current state of the art of edge AI in healthcare by using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology and analyzing more than 70 Web of Science articles. We have defined the relevant research questions, clear inclusion and exclusion criteria, and classified the research works in three main directions: privacy and security, AI-based optimization methods, and edge offloading techniques. The findings highlight the many advantages of integrating edge computing in a wide range of healthcare use cases requiring data privacy and security, near real-time decision-making, and efficient communication links, with the potential to transform future healthcare services and eHealth applications. However, further research is needed to enforce new security-preserving methods and for better orchestrating and coordinating the load in distributed and decentralized scenarios.
Assessing the Role of Policy in the Evolution of Recreational Fisheries in Chinese Fishing Villages: An Analytical Hierarchy Process (AHP) and Delphi Method Analysis
Authors: Shih Chun-Han , Wang Xin-Ruo , Lu Yu-Ming , Chu Ta-Jen
Published: September 2024

Recreational fisheries in Chinese fishing villages have undergone significant transformation due to supportive government policies. This study develops a comprehensive indicator to objectively assess the development of recreational fisheries under rural revitalization policies. Six key dimensions were identified using the Analytical Hierarchy Process (AHP) and the Delphi method. The findings indicate that fishery resource conditions and environmental conditions are paramount, followed by service conditions, activities, policy conditions, and accommodation conditions. Key success indicators indicate the importance and priority of implementing policies, including “Tasting delicious aquatic products”, “Government support”, “Recreational fishing activities pricing”, and “Talent revitalization.” This study concludes by offering strategic recommendations to prioritize recreational fisheries within rural revitalization policies, utilizing identified indicators for policy implementation, and establishing a dedicated promotional group. These insights are essential for stakeholders and policymakers to promote sustainable and economically viable recreational fisheries in China.
Fishery Management Enforcement Gradients to Achieve Fishery Goals
Authors: Karr Kendra A. , Pina-Amargós Fabián , Figueredo-Martín Tamara , Olivera-Espinosa Yunier
Published: September 2024

Marine protected areas (MPAs) can allow some fish populations to rebuild within their borders in areas impacted by overfishing, but the effectiveness of reserves is highly dependent on how effectively fishing mortality is controlled, which in turn depends on the level of fishery management implementation. In Cuba’s Gardens of the Queen MPA, the largest in the Caribbean, a variety of fishery management measures have been implemented to ensure the social, economic, and political viability of protecting such a large area. Here, we evaluate the biological response, in terms of fish density and the biomass of commercially valuable and ecologically important reef fish species, to a spatial gradient of fishery management enforcement, in terms of fish density and biomass, of commercially valuable and ecologically important reef fish species. The enforcement gradient is characterized by the level of protection, fishing effort, patrolling effort, distance to the nearest fishing port, and fishing intensity. Fish density and biomass were estimated from visual scuba surveys. Areas with higher levels of enforcement support higher levels of average biomass (up to 1378 kg/ha) and density (up to 2367 indv./ha) of commercially important fishes in comparison to areas with very low or no enforcement (estimates of 757 kg/ha average biomass and 1090 indv./ha average density, respectively). These fish density and biomass levels can serve as proxies in the development of harvest control rules that adjust fishing pressure according to the ratio of fished density or biomass to unfished density or biomass, through the use of the MPA Density Ratio method.
The Characterization of a Low-Calorie and Lactose-Free Brown Fermented Milk by the Hydrolysis of Different Enzymatic Lactose
Authors: Tao Han , Li Shuo-Qian , Fang Meng-Jia , Cai Wan-Hao , Zhang Song , Wang Hui-Li
Published: September 2024

The adoption of brown fermented milk in the normal diet and daily beverages is accompanied by significant sugar intake and a high public health burden. To reduce the sugar content in dairy products while maintaining optimal nutritional properties, a novel low-calorie, lactose-free brown fermented milk was developed through enzymatic hydrolysis and the Maillard reaction. The optimal product was achieved using low-temperature lactase, where the lactose and glucose content were reduced 33-fold and 2.4-fold to 0.06 g/100 g and 13.32 g/L, respectively, meeting the criteria for being lactose-free (<0.5 g/100 g). Meanwhile, hazardous compounds such as 5-hydroxymethylfurfural and 3-deoxyglucosone were reduced by more than 20%. After 28 days of storage, the water-holding capacity and suspension stability remained notably stable, and the protein composition was also more enriched compared to commercial milk. It is expected that this low-calorie dairy product may promote growth in the dairy market.
Sustainable Recovery of Polyphenols and Carotenoids from Horned Melon Peel via Cloud Point Extraction
Authors: Travičić Vanja , Cvanić Teodora , Vidović Senka , Pezo Lato , Hidalgo Alyssa , Šovljanski Olja , Ćetković Gordana
Published: September 2024

Using natural plant extracts as food additives is a promising approach for improving food products’ quality, nutritional value, and safety, offering advantages for both consumers and the environment. Therefore, the main goal of this study was to develop a sustainable method for extracting polyphenols and carotenoids from horned melon peel using the cloud point extraction (CPE) technique, intending to utilize it as a natural food additive. CPE is novel promising extraction method for separation and pre-concentration of different compounds while being simple, inexpensive, and low-toxic. Three parameters within the CPE approach, i.e., pH, equilibrium temperature, and equilibrium time, were investigated as independent variables through the implementation of Box–Behnken design and statistical analyses. The optimized conditions for the maximum recovery of both polyphenols and carotenoids, reaching 236.14 mg GAE/100 g and 13.80 mg β carotene/100 g, respectively, were a pH value of 7.32, an equilibrium temperature of 55 °C, and an equilibrium time of 43.03 min. The obtained bioactives’ recovery values under the optimized conditions corresponded to the predicted ones, indicating the suitability of the employed RSM model. These results highlight the effectiveness of CPE in extracting bioactive compounds with varying polarities from agricultural by-products, underscoring its potential for enhancing the value of food waste and advancing sustainable practices in food processing. According to microbiological food safety parameters, the optimal CPE extract is suitable for food applications, while its storage under refrigerated and dark conditions is particularly beneficial. The CPE extract’s enhanced stability under these conditions makes it a more viable option for long-term storage, preserving both safety and quality.
Exploring Novel Umami Peptides from Bovine Bone Soups Using Nano-HPLC-MS/MS and Molecular Docking
Authors: Yang Zheng , Li Wanying , Yang Ran , Qu Lingbo , Piao Chunxiang , Mu Baide , Niu Xiaodi , Li Guanhao , Zhao Changcheng
Published: September 2024

In this study, umami peptides were screened and characterized from bovine bone soups manufactured via atmospheric and high-pressure boiling. Peptide fractions with molecular weights less than 3 kDa were selected for peptide sequencing using LC-MS/MS, the toxicity prediction of the umami peptides was carried out by using an website, and the peptides were screened according to the binding energy, i.e., three peptides including YDAELS, TDVAHR, and ELELQ were selected. The three umami peptides were further synthesized, and their umami thresholds were determined through sensory evaluation and electronic tongue analysis, ranging from 0.375 to 0.75 mg/mL. All three peptides exhibited a significant synergistic taste enhancement effect when combined with MSG (monosodium glutamate) solution. The molecular docking of the umami peptides with the T1R1/T1R3 receptor revealed the mechanism of umami presentation, and the main interaction forces between the three umami peptides and the receptor were hydrogen bonding, electrostatic interactions, and hydrophobic interactions.
Salicylic Acid Treatment Ameliorates Postharvest Quality Deterioration in ‘France’ Prune (Prunus domestica L. ‘Ximei’) Fruit by Modulating the Antioxidant System
Authors: Zhang Xinling , Liu Yuxing , Zhang Weida , Yang Wanting , An Shuaibing , Guo Minrui , Chen Guogang
Published: September 2024

The potential of salicylic acid (SA) in delaying postharvest fruit senescence has been extensively documented; nevertheless, its effect on antioxidant activity and quality of ‘France’ prune fruit is largely unknown. The study investigated the effects of SA (0.5 mM) on postharvest quality deterioration of ‘France’ prune fruit. Results indicated that SA impeded the increase in respiration rate and weight loss, and mitigated the decrease of soluble solids content (SSC), titratable acidity (TA) content, firmness, and hue angle. SA sustained the ascorbate-glutathione cycle by inducing the production of ascorbic acid (AsA) and glutathione (GSH) and attenuates flavonoids, total phenols, and anthocyanins degradation by inhibiting polyphenol oxidase (PPO) activity and PdPPO. Moreover, SA significantly improved superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX), peroxidase (POD), and glutathione reductase (GR) activities and gene expression levels, sustained higher 2,2′-Azinobis-(3-ethylbenzthiazoline-6-sulphonate) (ABTS) and 1,1-diphenyl-2-picryl-hydrazyl (DPPH) free radical scavenging capacity, ferric reducing antioxidant power (FRAP), and hydroxyl radical (·OH) inhibition capacity, and impeded the production of hydrogen peroxide (H2O2) and superoxide anion (O2•−). Overall, SA improved the antioxidant capacity by inducing the synthesis of defense response-related substances and promoting antioxidant enzyme activities to sustain the storage quality of ‘France’ prune fruit.
A Novel Approach for Testing Fractional Cointegration in Panel Data Models with Fixed Effects
Authors: Olaniran Saidat Fehintola , Olaniran Oyebayo Ridwan , Allohibi Jeza , Alharbi Abdulmajeed Atiah
Published: September 2024

Fractional cointegration in time series data has been explored by several authors, but panel data applications have been largely neglected. A previous study of ours discovered that the Chen and Hurvich fractional cointegration test for time series was fairly robust to a moderate degree of heterogeneity across sections of the six tests considered. Therefore, this paper advances a customized version of the Chen and Hurvich methodology to detect cointegrating connections in panels with unobserved fixed effects. Specifically, we develop a test statistic that accommodates variation in the long-term cointegrating vectors and fractional cointegration parameters across observational units. The behavior of our proposed test is examined through extensive Monte Carlo experiments under various data-generating processes and circumstances. The findings reveal that our modified test performs quite well comparatively and can successfully identify fractional cointegrating relationships in panels, even in the presence of idiosyncratic disturbances unique to each cross-sectional unit. Furthermore, the proposed modified test procedure established the presence of long-run equilibrium between the exchange rate and labor wage of 36 countries’ agricultural markets.
Solutions for a Logarithmic Fractional Schrödinger-Poisson System with Asymptotic Potential
Authors: Guo Lifeng , Li Yuan , Liang Sihua
Published: September 2024

In this paper, we consider a logarithmic fractional Schrödinger-Poisson system where the potential is a sign-changing function. When the potential is coercive, we get the existence of infinitely many solutions for the system. When the potential is bounded, we get the existence of a ground state solution for the system.
17α-Ethynylestradiol and Levonorgestrel Exposure of Rainbow Trout RTL-W1 Cells at 18 °C and 21 °C Mainly Reveals Thermal Tolerance, Absence of Estrogenic Effects, and Progestin-Induced Upregulation of Detoxification Genes
Authors: Vilaça Margarida , Lopes Célia , Seabra Rosária , Rocha Eduardo
Published: September 2024

Fish are exposed to increased water temperatures and aquatic pollutants, including endocrine-disrupting compounds (EDCs). Although each stressor can disturb fish liver metabolism independently, combined effects may exist. To unveil the molecular mechanisms behind the effects of EDCs and temperature, fish liver cell lines are potential models needing better characterisation. Accordingly, we exposed the rainbow trout RTL-W1 cells (72 h), at 18 °C and 21 °C, to ethynylestradiol (EE2), levonorgestrel (LNG), and a mixture of both hormones (MIX) at 10 µM. The gene expression of a selection of targets related to detoxification (CYP1A, CYP3A27, GST, UGT, CAT, and MRP2), estrogen exposure (ERα, VtgA), lipid metabolism (FAS, FABP1, FATP1), and temperature stress (HSP70b) was analysed by RT-qPCR. GST expression was higher after LNG exposure at 21 °C than at 18 °C. LNG further enhanced the expression of CAT, while both LNG and MIX increased the expressions of CYP3A27 and MRP2. In contrast, FAS expression only increased in MIX, compared to the control. ERα, VtgA, UGT, CYP1A, HSP70b, FABP1, and FATP1 expressions were not influenced by the temperature or the tested EDCs. The RTL-W1 model was unresponsive to EE2 alone, sensitive to LNG (in detoxification pathway genes), and mainly insensitive to the temperature range but had the potential to unveil specific interactions.
Cenozoic Reactivation of the Penacova-Régua-Verin and Manteigas-Vilariça-Bragança Fault Systems (Iberian Peninsula): Implication in Their Seismogenic Potential
Authors: González-Muñoz Sandra , Martín-González Fidel
Published: September 2024

The Penacova-Régua-Verin (PRV) and the Manteigas-Vilariça-Bragança (MVB) are two of the longest faults of the Iberian Peninsula. These faults striking NNE–SSW, over lengths of >200 km, were developed during late-Variscan Orogeny and reactivated in response to the Alpine Cycle tectonics. Their tectonic evolution during Alpine compression (Cenozoic) and their implication in the active tectonic activity of Iberia are under discussion. Their recent tectonic activity is recorded in the vertical offset of geomorphological surfaces, in the associated pull-apart basins, and in M > 7 paleoseismic events. Based on the vertical surface offset of Pliocene surfaces (140–300 m for the MVB fault and 150–200 m for the PRV), together with the horizontal offset (1300–1600 m for MVBF fault and 600–1400 m for PRVF), we can conclude that they were reactivated as left-lateral strike-slip faults with a reverse component during the Pliocene (3.6 Ma)–present. These results indicate that these faults are not related to the strain transmission during the collision with Eurasia (Eocene–Oligocene). However, they are related to the intraplate strain of the southern collision with the African plate during the Upper Neogene. The estimated slip-rate is 0.2–0.5 mm/a for both faults. These slip-rates evidence important implications for the seismic hazard of this intraplate region.
The Association of Dietary Micronutrient Intake and Systemic Inflammation among Patients with Type 2 Diabetes: A Cross-Sectional Study
Authors: Izuora Kenneth , Alver Amalie , Basu Arpita , Batra Kavita , Williams Shelley J. , Ebersole Jeffrey L.
Published: September 2024

Inflammation contributes to the pathogenesis of type 2 diabetes (T2DM). This study sought to document how the systemic biomarkers of inflammation varied based on food choices among patients with T2DM. This cross-sectional study enrolled ambulatory patients with T2DM. Demographic and clinical information was collected. Five drops of fingerstick blood were collected using an absorbent paper device (HemaSpot HFR). C-reactive protein (CRP), serum amyloid A protein (SAA), and fibrinogen were measured using a Luminex assay. Patient-generated 7-day food diaries were analyzed using a validated food processor software. Data were analyzed by Pearson’s correlation tests, linear regression and logistic regression with the significance level set at 0.05. Among the 71 participants, 43 (60.6%) were females. The average age and duration of T2DM were 64.1 ± 10.3 and 15.8 ± 9.1 years, respectively. In a simple linear regression run with selected micronutrients, iron [F (1, 53) = 5.319, p < 0.05, adj. R2 = 0.074] significantly predicted plasma CRP. This significance was lost with multiple linear regressions including age, gender, BMI, T2DM duration, T2DM complications, glycohemoglobin A1c (HbA1c) and other micronutrients. The average intake of most micronutrients by the participants was below the recommended daily intake. A higher intake of iron-rich foods was associated with higher levels of systemic inflammation in a simple linear regression model, but the association was not present after adjusting for patient factors like age, gender, BMI and T2DM-related variables. This relationship needs to be explored further given the key role of inflammation in the pathogenesis of T2DM and its associated complications.
Oral Health Knowledge, Attitudes, and Learned Clinical Skills in Pediatric Medicine Residents and Nurse Practitioner Students: A Pre-Post Design
Authors: Love Laurie , Ramos-Gomez Francisco , Kinsler Janni J. , Cabrera-Mino Cristina , Garell Cambria , Pike Nancy A.
Published: September 2024

(1) Background/Objective: California has one of the highest rates of pediatric dental caries in the nation. One way to combat this problem is through non-dental provider training programs that focus on prevention. However, there are limited data on healthcare provider training program integration and evaluation of oral health curricula focused on prevention of early childhood caries. This study will assess the change in healthcare providers’ attitudes, knowledge, and skills by implementing an interprofessional educational (IPE) oral health curriculum in medicine and nurse practitioner programs at one university in Southern California. (2) Methods: A mixed method design was employed using a pre- and post-educational survey, and end-of-program focus group interviews. Descriptive statistics and paired t-tests were used to assess group differences and thematic analyses for the focus groups. (3) Results: A total of 81 students (14 pediatric medicine residents, 18 pediatric, and 49 family nurse practitioners) completed the curriculum and surveys. Attitudes related to oral hygiene remained unchanged, with the nurse practitioner group showing improved clinical skills (all questions; p < 0.021). Knowledge scores significantly improved across all groups (paired t-test; p < 0.001). All focus groups expressed the helpfulness of the educational modules, the usefulness of the skills learned, and the benefits of IPE activities. (4) Conclusion: Healthcare providers showed improved oral health knowledge and clinical skills acquired through the oral health program and can serve as a model to educate across disciplines on the prevention of early childhood caries.
Effect of Comprehensive Educational Program on Preeclamptic Women’s Risk Perception of Cardiovascular Disease, Self-Efficacy, and Adherence to Healthy Lifestyle Behaviors
Authors: Hussien Nahed Ahmed , Abd El-fatah Hend Ali Mohamed , Zhang Zhenxiang , Abdel-Aziz Hassanat Ramadan , Saleh Ahmad Mahmoud , Dhakal Kamala , Mei Yongxia , Khatap Asmaa Morgan Farahat
Published: September 2024

Purpose: To evaluate the effect of a comprehensive educational program on preeclamptic women’s knowledge, risk perception of cardiovascular disease, self-efficacy, and adherence to healthy lifestyle behaviors. Patients and methods: This study employed a pretest-posttest design. One hundred and two women who previously had preeclampsia were enrolled from July 2022 to December 2022 from outpatient obstetrics, gynecology, and family planning clinics. The primary and secondary outcomes were measured at baseline, after eight weeks, and after three months of the educational intervention. The data were analyzed using SPSS version 23, descriptive and inferential statistics, specifically the Chi-square test, independent t-tests, and repeated measures ANOVA. Results: A statistically significant difference was found between the two groups immediately post-intervention and the three-month follow-up, with a significant improvement among the intervention group than control group regarding cardiovascular disease knowledge (p < 0.001), risk perception (p < 0.001), self-efficacy (p < 0.001), and healthy lifestyle behaviors (p < 0.001). There was a statistically significant interaction between group and time regarding total cardiovascular disease risk perception (F = 203.67, p < 0.001, η2 = 0.673), self-efficacy (F = 70.06, p < 0.001, η2 = 0.405), and adherence to healthy lifestyle behaviors (F = 145.08, p < 0.001, η2 = 0.597). Conclusion: This study concluded that the comprehensive educational program had a positive effect on improving preeclamptic women’s knowledge and risk perception of CVD, self-efficacy, and adherence to healthy lifestyle behaviors following preeclampsia.
Investigating the Effectiveness of a Workplace Musculoskeletal Disorders Management Program
Authors: Grana Eleni , Galanis Petros , Velonakis Emmanuel , Tziaferi Styliani , Sourtzi Panayota
Published: September 2024

Musculoskeletal disorders (MSDs) present a major occupational health challenge, especially among office workers. Objective: To evaluate the effectiveness of a workplace intervention program for managing MSDs and measure its impact on presenteeism/absenteeism and health status. Methods: This semi-experimental study was conducted between May 2019 and October 2022 in Greece and involved 247 office workers randomly assigned to early and late intervention groups. The intervention included a seminar on ergonomics and proper workstation practices with a demonstration of exercises. Data were collected by the SF-36, the Standardised Nordic, and the Work Productivity and Activity Impairment Questionnaires. Results: In the early intervention group (n = 143), presenteeism significantly decreased (p = 0.045), from a mean value of 0.11 to 0.07, but not absenteeism. Significant improvements were observed in physical (p = 0.007) and mental health (p = 0.012). Reductions in pain were recorded for the neck (p = 0.032), shoulders (p = 0.015), wrists (p = 0.014), upper back, lower back, hips, and knees (p = 0.044 for each). In the late intervention group (n=104), there were no significant changes in absenteeism or presenteeism. Mental health improved significantly (p = 0.008), and reductions in pain were noted for the neck (p = 0.001), wrist (p = 0.0005), and upper back (p = 0.001). Conclusions: This workplace intervention program proved effective both in reducing pain in various body areas and reducing presenteeism, and improved physical and mental health were observed in the intervention groups while absenteeism remained unchanged.
Field Study and Numerical Modeling to Assess the Impact of On-Site Septic Systems on Groundwater Quality of Jeju Island, South Korea
Authors: Kim Mijin , Koh Eun-Hee , Kim Jinkeun
Published: September 2024

Septic-derived nitrogen (N) sources have harmful effects on water resources, humans, and ecosystems in several countries. On Jeju Island, South Korea, the rapid increase in personal sewage treatment facilities (PSTFs, also known as on-site septic systems) raises concerns regarding the deterioration of groundwater quality, as groundwater is the sole water resource on the island. Therefore, this study employed a field study and numerical modeling to assess the impact of PSTF effluents on groundwater quality in the Jocheon area of northeastern Jeju. Water quality analysis revealed that the total nitrogen (T-N) concentrations in the effluent exceeded the effluent standards (75–92% PSTFs). The numerical model simulated the transport of N species, showing limited NH4+ and NO2− plume migration near the surface due to nitrification and adsorption. However, NO3− concentrations increased and stabilized over time, leaching on the water table with higher levels in lowland areas and clustered PSTFs. The predictive model estimated a 79% reduction in NO3− leaching when the effluents followed standards, indicating the necessity of effective PSTF management. This study highlights the importance of managing improperly operated septic systems to mitigate groundwater contamination based on an understanding of the behavior of N species in subsurface hydrologic systems.
Adaptive Operating Rules for Flood Control of a Multi-Purpose Reservoir
Authors: Drobot Radu , Draghia Aurelian Florentin , Dinu Cristian , Sîrbu Nicolai , Chendeș Viorel , Mazilu Petrișor
Published: September 2024

Almost all multipurpose reservoirs in Romania were put into operation 30–50 years ago or even earlier. Meanwhile, a large volume of hydrologic data has been collected, and the initial design flood should be reconsidered. Consequently, the operating rules of flow control structures (bottom gates and weir gates) should be re-examined, mainly for medium and low-frequency floods. The design flood is not unique, being characterized by different shapes and time to peak, which has consequences for flood mitigation rules. Identifying the critical design flood is an important preliminary step, although it is usually neglected in flood management. Simulating the operation of the Stânca–Costești reservoir on the Prut River, it was found that the design flood corresponding to the maximum value of the compactness coefficient is the most difficult to mitigate considering the specific conditions of the dam and the reservoir: the prescribed conservation level in the reservoir, and the design flood volume of medium and rare floods that far exceeds the flood control volume. These conditions can jeopardize both dam safety and downstream flood protection. The main steps of the proposed approach are as follows: (1) developing the hydraulic model; (2) statistical processing of the registered floods and defining critical design floods for different AEPs (Annual Exceedance Probabilities); (3) deriving optimal operation rules based on a simulation-optimization model; (4) implementing real-time adaptive operation of the mechanical outlets; and (5) critically assessing the operating rules after the event. Based on the hydrological forecast, if necessary, new outlets are put into operation while keeping the ones already activated. Based on the hydrological forecast and properly operated, the safety of the Stânca–Costești dam is guaranteed even in the event of a 0.1% CC (Climate Change) flood. However, for floods greater than 1% magnitude, the carrying capacity of the downstream riverbed is exceeded. The main gaps addressed in this paper are the following: (1) the establishment of critical design floods, and (2) the adaptive operating rules of outlet devices aimed at optimizing flood control results, using short-term flood forecasts.
Decrease in Socioeconomic Disparities in Self-Rated Oral Health among Brazilian Adults between 2013 and 2019: Results from the National Health Survey
Authors: Soares Anna Rachel dos Santos , Fonseca Maria Luiza Viana , Malta Deborah Carvalho , Chalub Loliza Luiz Figueiredo Houri , Ferreira Raquel Conceição
Published: September 2024

This cross-sectional study assessed the magnitude of inequalities in self-rated oral health (SROH) among different socioeconomic groups in Brazil. Secondary data from interviews with a sample of adults (≥18 years) from the national health survey 2013 (n = 64,308) and 2019 (n = 88,531) were analyzed. Positive SROH was considered when participants selected the good or very good options. Socioeconomic indicators were monthly household income and years of education. The magnitude of inequalities among socioeconomic groups was estimated using the Slope (SII) and Relative Index of Inequality (RII). Interaction term assessed changes in SII/RII over time. Estimates were adjusted for sex and age. The prevalence of SROH was 67.50% in 2013 and 69.68% in 2019. Individuals with lower socioeconomic indicators had a lower prevalence of positive SROH. Significant reductions in the magnitude of the education-based RII between 2013 (1.58) and 2019 (1.48) in Brazil, as well as in north (1.70; 1.45) and northeast (1.50; 1.41) regions and reduction in the income-based RII in the north (1.71; 1.51) were observed. Socioeconomic inequalities in SROH persist across different Brazilian regions, although there was a reduction in disparities among education groups in 2019 compared with 2013. The findings of this study suggest that equitable Brazilian oral health policies may have contributed to reducing SROH inequality over time.
Study on the Effectiveness of a Copper Electrostatic Filtration System “Aerok 1.0” for Air Disinfection
Authors: Albertini Roberto , Colucci Maria Eugenia , Viani Isabella , Capobianco Emanuela , Serpentino Michele , Coluccia Alessia , Mohieldin Mahgoub Ibrahim Mostafa , Zoni Roberta , Affanni Paola , Veronesi Licia , Pasquarella Cesira
Published: September 2024

Background: Bioaerosols can represent a danger to health. During SARS-CoV-2 pandemic, portable devices were used in different environments and considered a valuable prevention tool. This study has evaluated the effectiveness of the air treatment device “AEROK 1.0®” in reducing microbial, particulate, and pollen airborne contamination indoors, during normal activity. Methods: In an administrative room, airborne microbial contamination was measured using active (DUOSAS 360 and MD8) and passive sampling; a particle counter was used to evaluate particle concentrations; a Hirst-type pollen trap was used to assess airborne pollen and Alternaria spores. Statistical analysis was performed using SPSS 26.0; p values < 0.05 were considered statistically significant. Results: The airborne bacterial contamination assessed by the two different samplers decreased by 56% and 69%, respectively. The airborne bacterial contamination assessed by passive sampling decreased by 44%. For fungi, the reduction was 39% by active sampling. Airborne particles (diameters ≥ 1.0, 2.0 μm) and the ratio of indoor/outdoor concentrations of total pollen and Alternaria spp. spores significantly decreased. Conclusions: The results highlight the effectiveness of AEROK 1.0® in reducing airborne contamination. The approach carried out represents a contribution to the definition of a standardized model for evaluating the effectiveness of devices to be used for air disinfection.
Supporting Women after Obstetric Fistula Surgery to Enhance Their Social Participation and Inclusion
Authors: Debele Tibeb , Aldersey Heather M. , Macdonald Danielle , Mengistu Zelalem , Mekonnen Dawit Gebeyehu , Batorowicz Beata
Published: September 2024

Obstetric fistula is a childbirth complication causing abnormal openings between the urinary, bowel, and genital tracts, leading to involuntary leakage and potential long-term disability. Even after surgical repair, women continue to face psychological and social challenges that affect their social inclusion and participation. This study explored family and service provider perspectives on current support systems and identified gaps affecting women’s inclusion and participation post-fistula surgery. Building on a prior study of women who underwent obstetric fistula surgical repair, we qualitatively examined available formal and informal post-surgical supports in Ethiopia. We conducted 20 interviews with family members and service providers and analyzed them using Charmaz’s grounded theory inductive analysis approach. We identified four themes that indicated the available formal support in fistula care, the impact of formal support on women’s social participation and inclusion, the gaps in formal support systems, and post-surgery informal supports and their challenges. Both groups believed support needs for women after surgery remain unmet, highlighting the need to strengthen holistic support services to improve women’s social inclusion and participation. This study contributes to limited research on formal and informal support for women, emphasizing the need for enhanced economic, psychological, and sexual health-related support post-obstetric fistula surgery.
The Protective Role of Interleukin-37 in Cardiovascular Diseases through Ferroptosis Modulation
Authors: Cruz-Gregorio Alfredo , Amezcua-Guerra Luis M. , Fisher-Bautista Brandon , Romero-Beltrán Abraham , Fonseca-Camarillo Gabriela
Published: September 2024

The role of ferroptosis and iron metabolism dysregulation in the pathophysiology of cardiovascular diseases is increasingly recognized. Conditions such as hypertension, cardiomyopathy, atherosclerosis, myocardial ischemia/reperfusion injury, heart failure, and cardiovascular complications associated with COVID-19 have been linked to these processes. Inflammation is central to these conditions, prompting exploration into the inflammatory and immunoregulatory molecular pathways that mediate ferroptosis and its contribution to cardiovascular disease progression. Notably, emerging evidence highlights interleukin-37 as a protective cytokine with the ability to activate the nuclear factor erythroid 2-related factor 2 pathway, inhibit macrophage ferroptosis, and attenuate atherosclerosis progression in murine models. However, a comprehensive review focusing on interleukin-37 and its protective role against ferroptosis in CVD is currently lacking. This review aims to fill this gap by summarizing existing knowledge on interleukin-37, including its regulatory functions and impact on ferroptosis in conditions such as atherosclerosis and myocardial infarction. We also explore experimental strategies and propose that targeting interleukin-37 to modulate ferroptosis presents a promising therapeutic approach for the prevention and treatment of cardiovascular diseases.
CD26 Is Differentially Expressed throughout the Life Cycle of Infantile Hemangiomas and Characterizes the Proliferative Phase
Authors: Lorusso Bruno , Nogara Antonella , Fioretzaki Rodanthi , Corradini Emilia , Bove Roberta , Roti Giovanni , Gherli Andrea , Montanaro Anna , Monica Gregorio , Cavazzini Filippo , Bonomini Sabrina , Graiani Gallia , Silini Enrico Maria , Gnetti Letizia , Pilato Francesco Paolo , Cerasoli Giuseppe , Quaini Federico , Lagrasta Costanza Anna Maria
Published: September 2024

Infantile hemangiomas (IHs) are benign vascular neoplasms of childhood (prevalence 5–10%) due to the abnormal proliferation of endothelial cells. IHs are characterized by a peculiar natural life cycle enclosing three phases: proliferative (≤12 months), involuting (≥13 months), and involuted (up to 4–7 years). The mechanisms underlying this neoplastic disease still remain uncovered. Twenty-seven IH tissue specimens (15 proliferative and 12 involuting) were subjected to hematoxylin and eosin staining and a panel of diagnostic markers by immunohistochemistry. WT1, nestin, CD133, and CD26 were also analyzed. Moreover, CD31pos/CD26pos proliferative hemangioma–derived endothelial cells (Hem-ECs) were freshly isolated, exposed to vildagliptin (a DPP-IV/CD26 inhibitor), and tested for cell survival and proliferation by MTT assay, FACS analysis, and Western blot assay. All IHs displayed positive CD31, GLUT1, WT1, and nestin immunostaining but were negative for D2-40. Increased endothelial cell proliferation in IH samples was documented by ki67 labeling. All endothelia of proliferative IHs were positive for CD26 (100%), while only 10 expressed CD133 (66.6%). Surprisingly, seven involuting IH samples (58.3%) exhibited coexisting proliferative and involuting aspects in the same hemangiomatous lesion. Importantly, proliferative areas were characterized by CD26 immunolabeling, at variance from involuting sites that were always CD26 negative. Finally, in vitro DPP-IV pharmacological inhibition by vildagliptin significantly reduced Hem-ECs proliferation through the modulation of ki67 and induced cell cycle arrest associated with the upregulation of p21 protein expression. Taken together, our findings suggest that CD26 might represent a reliable biomarker to detect proliferative sites and unveil non-regressive IHs after a 12-month life cycle.