bluuebunny/crossref_metadata_2025 huggingface dataset:
Modelo sobre adaptabilidad de estudiantes en tránsito en la universidad
Authors: López-Aguilar David , Álvarez-Pérez Pedro Ricardo , González-Benítez Nicole
Published: April 2023

Un problema que preocupa a nivel mundial son las elevadas cifras de abandono de los estudios universitarios. Desde la necesidad de aportar respuestas a este fenómeno, en este estudio se presenta un modelo predictivo sobre el nivel de adaptabilidad del alumnado de bachillerato con intención de cursar estudios universitarios. El objetivo es mostrar las relaciones existentes entre las tres variables exógenas (competencias para el estudio, información sobre la universidad y expectativas de autoeficacia) y la variable endógena (adaptabilidad) contempladas en el modelo. En el trabajo participó una muestra de 290 estudiantes de bachillerato que habían manifestado su intención de cursar estudios universitarios. Los resultados indican una relación sustancial y consistente entre las variables del modelo, ayudando a predecir los niveles de adaptabilidad académica de los estudiantes de bachillerato con intención de cursar estudios universitarios. Esto resulta de interés para diseñar propuestas orientadoras para las etapas previas a la universidad.
Some Implications of the Multifractal Informational Entropy
Authors: Gavriluț Gabriel , Agop Ștefana , Rusu Cristina-Marcela , Petrescu Tudor-Cristian , Ștefan Gavril , Oprea Iuliana
Published: April 2023

A new formulation of the informational entropy on multifractal manifolds is proposed. In such a context, some connections with known results from the dynamics of complex systems are presented: correlations of SL(2ℝ) groups with Hamiltonian formalism, simultaneous invariances between two groups (coordinate group and parametric group), linear harmonic oscillator/oscillator ensemble dynamics from the perspective of SL(2ℝ) groups, uncertainty relations on multifractal manifolds etc. Moreover, the existence of a multifractal perspective in the complex dynamics analysis allows direct correspondences with deep learning algorithms.
Gravitational Interaction Mediated by Classical Zero Point Field
Authors: Simaciu Ion , Borsos Zoltan , Dumitrescu Gheorghe , Drafta Viorel
Published: April 2023

By modeling the particle as a two-dimensional oscillator with the natural angular frequency equal to the Zitterbewegung frequency, the expression of the gravitational force between two particles is obtained. Gravitational force is the effect of the absorption-scattering of the CZPF background by the oscillators. The connection between the gravitational and the electrostatic interaction is obtained.
Political and Economic Aspects of Brexit Impact on Accounting Legislation in the UK – New Directions in Standards (GAAP UK and IFRS)
Authors: Shkulipa Liudmyla
Published: April 2023

Post-Brexit is currently being researched as not only an important geopolitical change but also as an economically conflicted period that constantly generates many issues in finance, accounting, and taxation. This paper aims to consider, identify and forecast – whether and what – the new directions for the development of IFRS and GAAP UK after Brexit. The research methods are based on a deductive research approach with elements of descriptive content analysis. The results of the study helped to determine the development direction of accounting in the UK after Brexit in the short term – the continued application of IFRS, adopted by the EU. However, it is obtained that the task of the British government – to harmonize its sovereignty with IFRS, taking into account the requirements of the EU – is being successfully implemented. So, the direction of the development of British accounting in the future – is the creation of its mechanism for the approval of national standards, controlled by the government. However, the British accounting system and IFRSs have many unresolved issues after Brexit that might be the subject of future studies.
Czech Corporate Effective Tax Rate as Investors Costs Changes with Times
Authors: Rohan Jan , Moravec Lukáš , Kukalová Gabriela , Ječmínek Jakub , Hinke Jana
Published: April 2023

When choosing the appropriate jurisdiction, trading companies need to consider many variables. This can include administrative burdens, the speed of establishment of a company, the granting of some degree of anonymity of ownership, and a friendly tax environment. This article is focused on finding the corporate effective tax rate in the Czech Republic in the period 2005–2017 with the database of the Czech tax administrator. In the light of the international tax law, the information concerning effective tax rates becoming necessary. The results of this study show that the nominal tax rate may not be decisive for the determination of the tax burden, as most countries allow the application of tax allowances and deductions and thus achieve virtually lower taxes.
The Right to Remedy Corporate Relations: A Question of Theoretical Certainty
Authors: Kostruba Anatoliy V.
Published: April 2023

Sometimes the interests of participants in corporate relations begin to contradict each other, corporate conflicts and corporate legal disputes arise, and often participants in the conflict abuse their rights, paralysing the company’s activities. In this case, it is necessary to find an appropriate solution for modifying the Ukrainian corporate law system and legislatively ensure effective remedies for the rights of participants in business companies. The following methods were used during the study: general scientific methods (concrete historical, Aristotelian, structural-functional, system-structural, etc.), special methods (comparative legal, modelling, system interpretation, legal technical), dialectical method of cognition, involvement of scientific tools of related humanities disciplines, a conceptual approach. The main steps to solve the problems of protecting the rights of participants and ensuring equal treatment were as follows: improving the legislation governing the activities of business companies; combining rules that ensure the rights of participants and guarantee their remedying under charters and internal documents. The judicial remedying of the company members’ rights on the territory of Ukraine remains ineffective, which, in turn, is attributed by researchers to the discretion of the judiciary and the inability of courts to interfere in certain issues within the framework of corporate conflicts. At the same time, in this context, it is advisable to adapt the positive practices legalised in Germany, which would allow modifying existing approaches to organising corporate relations and remedying the rights of participants. Moreover, the convergence of legal systems and legal regulation of corporate relations is one of the most noticeable trends in the development of corporate legislation around the world.
Abuse of the Social System in the Czech Republic
Authors: Bína Dana , Moravec Lukáš , Kukalová Gabriela , Mrázová Eliška , Cvik Daniela
Published: April 2023

The aim of the paper was to identify areas of possible abuse of social security support in the Czech Republic, with a specific focus on the Ústí nad Labem Region and the Litoměřice district, and to estimate the volume of social security support drawn in conflict with the legal regulations of the Czech Republic. In the Ústí nad Labem Region, spending on social security increased by 34.9% in the years 2016–2020. Upon a detailed focus on the Litoměřice district in the monitored period of 2018–2020, there were 69 fraud cases in the Litoměřice district within the scope of the social security system and illness benefit. Over 60% of this fraud and loss was deferred. The biggest shortcoming of the Czech Republic’s social system is the fact that individual institutions have little or no chance of finding out whether applicants are entering truthful information in the forms. A change of legal regulations and mandatory checks on applicants is the path towards reducing the amount of fraud and loss in social security and illness benefit.
Facile Green Synthesis of Cinnamomum tamala Extract Capped Silver Nanoparticles and its Biological Applications
Authors: Narath Sajina , Shankar S. Sharath , Sivan Saranya Kothaplamoottil , George Bini , Thomas T. Dennis , Sabarinath Sankarannair , Jayaprakash Sajithkumar K. , Wacławek Stanisław , Padil Vinod V.T.
Published: April 2023

The plant mediated biogenic synthesis of nanoparticles is of magnificent concern due to its eco-benign and single pot nature. Here, Cinnamomum tamala (C. tamala) aqueous leaf extract was utilised for the silver nanoparticles’ (Ag NPs) synthesis. The phytoconstituents in the leaf extract were analysed by standard methods. These metabolites, especially carbohydrate polymers reduce Ag ions to Ag NPs accompanied by a reddish-brown coloration of the reaction mixture. The visual observation of intense brown colour is the first indication of the formation of Ag NPs. Various spectro-analytical techniques further characterise the Ag NPs. The green synthesised spherical Ag NPs were crystalline with an average size of 38 nm. The Ag NPs were scrutinised for antioxidant, antimicrobial and cytotoxic activity and obtained good results. The free radical scavenging was studied by 2, 2-Diphenyl-l-picrylhydrazyl (DPPH) assay. The antibacterial activity of Ag NPs was assessed against human pathogens, and it shown to have good antibacterial potency against a wide spectrum of bacteria. The cytotoxic activity against HEK-293T (human embryonic kidney) cell line was evaluated by 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) assay. These potent biological activities enable C. tamala capped Ag NPs to be suitable candidates for the future applications in various fields, predominantly clinical and biomedical.
The impact of regulatory quality on deepens level of financial integration: Evidence from the European Union countries (NMS-10)
Authors: Ahmić Azra , Isović Ilma
Published: April 2023

This study seeks to empirically explore whether the regulatory quality in the NMS-10 impacts deepening international financial integration and whether the strengthening of regulatory quality for NMS-10 has a causal effect on the level of international financial integration (IFI) in NMS-10. The study covers NMS-10 between 1995 and 2020. The estimation of parameters was made with descriptive statistics, the Breusch-Pagan test, the Pesaran test, the Granger causality test, and OLS regression to analyze the impact of REQ on IFI. The findings of the study reveal that regulatory quality has a statistically significant effect in deepening the process of financial integration for both periods, in the pre-accession and post-accession EU process. In addition, the results demonstrate that the regulatory quality of NMS-10 provides sound laws and policies that support the business environment, encourage cross-bordering financial transactions. Moreover, the results of the Granger causality test show that the level of global financial integration is causally impacted by the improvement in NMS-10 regulatory quality. This indicates that regulatory effectiveness might predicts international financial integration.
On Perceiving Abs nces
Authors: Varzi Achille C.
Published: April 2023

Can we really perceive absences, i.e., missing things? Sartre tells us that when he arrived late for his appointment at the café, he saw the absence of his friend Pierre. Is that really what he saw? Where was it, exactly? Why didn’t Sartre see the absence of other people who were not there? Why did other people who were there not see the absence of Pierre? The perception of absences gives rise to a host of conundrums and is constantly on the verge of conceptual confusion. Here I focus on the need to be clear about four sorts of distinctions: (i) the difference between perceiving an absence and perceiving something that is absent; (ii) the difference between perceiving an absence and an absence of perceiving; (iii) the difference between perceiving an absence and perceiving something as an absence; and (iv) the difference between perceiving an absence and perceiving that something is absent.
Wide open? Creative industries and open strategizing challenges
Authors: Radomska Joanna , Hajdas Monika , Wołczek Przemysław , Glinka Beata
Published: April 2023

Purpose

Although the open strategizing (OS) approach can bring a wide range of benefits, there are also numerous risks identified. These risks are core sources of organizational dilemmas and challenges that appear in the decision-making process in two dimensions of OS – inclusion and transparency, both of which we further explore.

Design/methodology/approach

Following the suggestions of some scholars, we have employed the specific context of research and investigated companies from creative industries in Poland. We applied purposeful sampling with maximum sample variation to collect relevant and rich data and identify shared patterns. We conducted in-depth interviews with the owners or CEOs of the chosen creative firms.

Findings

We have recognized some recurring fears and anxieties accompanying the OS concept in general and different categories of challenges in particular. This paper suggests that a specific mindset reflected in a particular organizational climate (open climate) might undermine a company’s efforts in considering and adopting such a strategy.

Originality

By offering an initial conceptualization of an open climate as a potential further research avenue, this study contributes to the OS stream of research.
Incidental Discovery of a Cardiac Thrombus Mimicking a Right Atrial Myxoma in a Young Female Patient – A Case Report
Authors: Oltean Monica Alexandra , Caloian Bogdan , Irimie Diana Andrada , Pop Dana
Published: April 2023

Introduction

Cardiac masses are at the attention of health specialists since the development of echocardiography. Even though imaging is an excellent tool for diagnosis, the clinical presentation, risk factors, and hemodynamic status of the patients are important in establishing the diagnosis and subsequent management. The purpose of this presentation is to assess the difficulty of diagnosis in the case of an intracardiac mass and its therapeutic management.

Case report

A 29-year-old female with paresthesia in the left arm and a systolic tricuspid murmur underwent echocardiography, which revealed a mass of 35/20 mm in the right atrium. Due to the high embolic risk, the patient was referred to the cardiac surgery department and underwent surgical removal of the cardiac mass, which presented the macroscopical aspect of a myxoma. However, the histopathological examination revealed a right atrial thrombus.

Conclusion

Right heart thrombi represent a challenging diagnosis that involves a multidisciplinary team for the diagnosis and treatment of the patient.
Internal Audit as a Tool to Reduce the Risk of Fraud and Abuse
Authors: Skoczylas-Tworek Agnieszka
Published: April 2023

Objective

The purpose of the publication is to present auditing as a tool to reduce the risk of fraud and abuse. The article describes the role of auditing in minimizing fraud, its application in business entities and its effectiveness. It presents the role of both internal and external auditing in reducing fraud.

Methodology

Both the qualitative and quantitative methods were applied in the publication. The former was used for the purpose of presenting the application of auditing in business practice, and the latter to describe the effectiveness of its operation.

Findings

The results of the analysis showed that auditing is an effective tool for reducing fraud and abuse. Significant effectiveness in this regard is exhibited by internal audit services.

Value Added

The publication is part of a series of articles describing tools for reducing fraud and abuse. It shows the application of selected tools at the organizational level and their effectiveness. It also helps answer the question concerning the validity of the tools’ implementation and provides a premise for further research to develop a comprehensive model for combating fraud in business entities.

Recommendations

Research on the use of auditing as a tool for reducing fraud and abuse should be conducted with a breakdown of entities by industry. This will allow verification of which industry is characterized by the greatest use of auditing in this regard. It will also make it possible to assess the effectiveness of the measures taken to minimize the risk of fraud by industry entities.
О состоянии почвенно-растительного покрова южного сектора Дальнего Востока России и проблемах его рационального использования. Часть 2
Authors: Наумов Юрий Анатольевич
Published: April 2023

Статья посвящена изучению состояния почвенно-растительного покрова южного сектора Дальнего Востока России. В результате показано, что наибольшей антропогенной трансформацией этот покров подвергался в южной половине Дальнего Востока, особенно в Приморском крае, что связанно с наиболее ранним и самым интенсивным освоением природных ресурсов этого региона. Автором даны рекомендации по рациональному использованию почвенных и растительных ресурсов. Ключевые слова: вырубка лесов, пожары, лесопереработка, экологическое состояние, дикоросы.
Развитие и исторический вклад русской эмигрантской прессы в Харбине (Китай) в 1920–1940-х гг.
Authors:   Институт России Академии общественных наук провинции Хэйлунцзян, Харбин, Мэй Чжан
Published: April 2023

В период с конца XIX века до первой половины XX века произошло несколько волн массовой миграции российских эмигрантов в Китай. Русская диаспора в Китае также стала ярким историческим явлением XX века. Русские эмигранты прибыли в Китай в большом количестве, причем наибольшее число их было в Харбине и Шанхае. Русские эмигранты поселились здесь и постепенно интегрировались в жизнь местного населения. На пике своего развития в Харбине проживало более 200 тыс. русских, что намного превышало численность местного населения, поэтому Харбин одно время считался "столицей" русской диаспоры в Китае. Они основывали школы, издавали газеты и журналы, строили церкви, оставили свой след в политической, экономической и социальной жизни Харбина и вписали славную главу в культурную историю русской диаспоры. Поскольку публикация газет русских эмигрантов достигла своего пика в 1920-х–1940-х гг, данная статья посвящена публикациям газет и журналов русских эмигрантов в Харбине в этот период. Ключевые слова: Харбин, русская диаспора, издание газет и журналов.
Влияние пандемии COVID на социально-экономическое положение китайских мигрантов в России
Authors: На Ван , Леонтьева Эльвира Октавьевна , Леонтьева Полина Юрьевна
Published: April 2023

: В статье на материале интервью рассматриваются изменения в жизни и в трудовой деятельности китайских мигрантов, ориентированных на долгосрочное проживание и ведение бизнеса в России. Выявлено, что влияние пандемии, обычно негативно оцениваемое экспертами на макроуровне, на микроуровне привело к структурным изменениям этнического бизнеса и адаптацией мигрантов к новым вызовам: у кого-то финансовая сторона изменилась к лучшему, кто-то обанкротился, а кто-то не заметил существенной разницы, кроме изменения формы оказания услуг. Выделенные нами последствия мы рассматриваем по трём основным направлениям: изменения в экономическом положении мигрантов и в структуре китайского предпринимательства, перенос экономической активности в виртуальное пространство и изменения в социальном самочувствии и жизненных планах. Ключевые слова: пандемия COVID, китайские мигранты, миграция, китайское предпринимательство
Столкновение с новыми вызовами: влияние COVID-19 на восприятие нетрадиционных аспектов безопасности в Юго-Восточной Азии
Authors: Золотухин Иван Николаевич
Published: April 2023

Статья представляет собой рецензию на коллективную монографию "Нетрадиционные пробле- мы безопасности в условиях новой нормальности", изданную Школой международных исследований им. С. Раджаратнама Наньянского технологического университета (Сингапур) и посвящённую оценке и видению ведущими экспертами и аналитиками ситуации в Юго-Восточной Азии (ЮВА) в результате столкновения региона с COVID-19. В рецензии отражены последствия влияния пандемии на региональную систему противодействия нетрадиционным вызовам безопасности, даётся оценка её эффективности перед лицом новых угроз, предлагаются варианты достижения устойчивой безопасности и благоприятной среды для жизни в ЮВА. Ключевые слова: Юго-Восточная Азия, АСЕАН, нетрадиционные проблемы безопасности, новая нормальность, гуманитарная помощь, новые угрозы, устойчивая безопасность
"Современные исторические и историко-антропологические исследования Евразии": о международном научно-практическом семинаре в Якутске
Authors: Винокурова Анна Викторовна , Яковлев Айтал Игоревич , Яковлева Капитолина Максимовна
Published: April 2023

В сообщении представлен обзор основных мероприятий международного научно-практического семинара "Современные исторические и историко-антропологические исследования Евразии". Главная цель семинара состояла в широком обсуждении актуальных вопросов изучения адаптации традиционных систем жизнеобеспечения скотоводов Центральной и Северо-Восточной Азии к современным социокультурным процессам, трансформации скотоводческих культур в условиях урбанизации, регионализации и переломных моментов культурной глобализации. Ключевые слова: социальные трансформации, скотоводческие культуры, социокультурные процессы, исторические и антропологические исследования, количественные и качественные методы, региональное развитие, Евразия
PERAN BERSYUKUR TERHADAP PERILAKU KEWARGANEGARAAN ORGANISASIONAL PADA GURU DENGAN DUKUNGAN ATASAN SEBAGAI MEDIATOR
Authors: Santika Amelia Dewi , Rostiana Rostiana
Published: April 2023

This study aims to determine the role of Gratitude in Organizational Citizenship Behavior by considering the Supervisor Support as mediator. The participants of this study were 100 teachers at junior high schools and senior high schools in DKI Jakarta using a non-probability sampling method with a purposive sampling technique. This study uses a non-experimental quantitative design with a correlational approach with the help of the SPSS program. Data was collected by distributing questionnaires using the Gratitude at Work Scale (GAWS), Teachers’ Organizational Citizenship Behavior, Survey of Perceived Supervisor Support (SPSS). The results of this study indicate that being grateful contributes to PKO. Furthermore, PSS proved to play a role as a mediator between Gratitude and OCB, in which case it was proven that the role of Gratitude for OCB increased when employees felt support from the supervisor (PSS).
Perang Rusia-Ukraina, Gangguan Transportasi Multimoda, dan Kerawanan Rantai Pasokan Pangan Global
Authors: Henriette Pattipeilhy Shary Charlotte , C. Sitompul Yuveline Aurora
Published: April 2023

Konflik Rusia-Ukraina yang dimulai tahun 2014 telah mencapai puncaknya pada tahun 2022. Pasca konflik ini, tarif angkutan laut internasional meningkat dengan tajam dan kelangkaan pangan mulai terjadi di Uni Eropa dan negara-negara lain di dunia. Bahkan tingkat kelaparan di negara-negara miskin atau yang sedang dilanda konflik sipil seperti di Afrika semakin meningkat. Artikel ini menggunakan metode kualitatif dengan jenis eksplanatif yang berupaya untuk menjelaskan mengapa perang Rusia-Ukraina telah menyebabkan kerawanan pangan global. Metode pengumpulan data sekunder melalui analisa laporan-laporan organisasi internasional, jurnal, dan buku. Artikel ini menggunakan teori konflik internasional dan global supply chain, serta konsep transportasi multimoda internasional dan food security. Hasil analisis data dari artikel ini menunjukkan bahwa konflik Rusia-Ukraina telah melumpuhkan distribusi pangan dari dan ke Ukraina akibat serangan ke pelabuhan-pelabuhan besar di Ukraina, blokade Laut Hitam oleh Rusia, serta distribusi pangan melalui jalur alternatif ternyata tidak efektif. Padahal Uni Eropa serta negara-negara di kawasan Afrika dan Timur Tengah menggantungkan suplai gandumnya dari Rusia dan Ukraina. Sanksi-sanksi yang dilayangkan oleh dunia internasional terhadap transportasi dari negara Rusia semakin memperparah kondisi ini. Berkaca dari artikel ini dapat ditarik kesimpulan bahwa kebijakan yang terbaik untuk mengatasi kerawanan pangan global akibat konflik Rusia-Ukraina adalah melalui kerja sama intensif antara pelaku usaha serta pembuat kebijakan lintas batas negara terutama negara-negara tetangga di sekitar Ukraina untuk menjamin distribusi pangan global. Artikel ini dapat dijadikan acuan bagi artikel-artikel selanjutnya untuk mencari solusi terbaik bagi gangguan rantai suplai makanan dalam situasi konflik.
Integrasi Sistem Angkutan Umum Perkotaan Guna Meningkatkan Peran Perkeretaapian Di Kawasan Perkotaan Mebidangro
Authors: Wismadi Arif , Irawan M. Zhudy , Nugroho Deni Prasetio , Listantari Listantari , Gusleni Yessi
Published: April 2023

Kawasan Mebidangro memiliki permasalahan transportasi berupa kemacetan di jam sibuk karena rendahnya pengguna angkutan umum, simpul transportasi yang sepi dari aktifitas penumpang, dan perilaku masyarakat yang cenderung memilih menggunakan kendaraan pribadi dan angkutan online dari pada angkutan umum. Moda yang ada di Kawasan Mebidangro dilayani moda udara, moda darat, dan moda rel, namun belum secara efektif dapat melayani pergerakan di kawasan ini. Sehingga diperlukan evaluasi transportasi eksisting untuk mengetahui permasalahan yang terjadi. Artikel ini bertujuan untuk mengintegrasikan jaringan transportasi angkutan umum yang terdiri dari jaringan prasarana, jaringan pelayanan dan layanan, yang terfokus pada simpul transportasi guna memfasilitasi penumpang untuk beralih moda dalam satu perjalanan yang menerus. Metode Business Model Canvas digunakan untuk mengevaluasi layanan eksisting untuk mendapatkan usulan bisnis yang lebih baik kedepan. Hasil penelitian menunjukkan bahwa untuk mengembalikan peran angkutan umum perkotaan khususnya angkutan massal kereta api dalam jangka pendek berupa integrasi dan rekonsolidasi, lajur khusus semua rute angkutan umum dan penambahan layanan KA Bandara dengan door-to-door dan smart service agar perjalanan seamless menuju ke tujuan. Tahap jangka menengah melakukan rekonsolidasi zonasi sekolah dan rute angkutan umum perkotaan, penyediaan integrasi fisik layanan di stasiun KA dengan shelter BRT maupun halte angkutan pengumpan (feeder) untuk kemudahan melakukan alihmoda dan reaktivasi rute kereta api Pusat Kota – Belawan untuk pergerakan penumpang. Tahap jangka panjang mengubah bisnis angkutan barang sebagai penutup defisit angkutan penumpang dan memanfaatkan TOD di perlintasan sebidang dan di atas terminal dan bangunan publikuntuk mentrigger pergerakan penumpang menggunakan angkutan umum.
Konektivitas Jaringan Infrastruktur Transportasi Pariwisata (Studi Kasus Mandalika dan Labuan Bajo)
Authors: Munawar Achmad , Wismadi Arif , Dewanti Dewanti , Nugroho Deni Prasetio , Harmanto Jan Prabowo , Pasaribu Rita
Published: April 2023

Konektivitas jaringan infrastruktur transportasi antar simpul transportasi menuju kawasan pariwisata di Mandalika NTB dan Labuan Bajo NTT perlu dukungan Pemerintah dan pemangku kebijakan terkait. Ketersediaan dan kemudahan akses dari dan menuju kawasan wisata ini tentu akan menjadi daya tarik bagi wisatawan yang akan menikmati kawasan pariwisata. Artikel ini bertujuan menilai konektivitas transportasi antar moda wilayah di kawasan pariwisata Mandalika dan Labuan Bajo. Metode yang digunakan adalah mengukur nilai konektivitas jaringan infrastruktur transportasi antar simpul transportasi di kawasan pariwisata dan jaringan jalan penghubungnya. Permasalahan transportasi pariwisata tidak hanya terkait prasarana transportasi ke dan/dari kawasan wisata tetapi juga pergerakan di dalam kawasan wisata itu sendiri. Integrasi jaringan lokal dengan jaringan regional harus tersedia dengan baik agar perubahan mobilitas dari perjalanan ke/dari destinasi wisata dan perjalanan menikmati obyek wisata bisa dilakukan dengan mudah. Berdasarkan hasil analisis konektivitas, Mandalika memiliki sifat jaringan yang kompleks dan konektivitas sedang dengan nilai indeks beta (β) sebesar 1,294 dengan indeks gamma (γ) 0,489, sedangkan Labuan Bajo memiliki sifat jaringan sederhana dan konektivitas rendah dengan indeks beta (β) sebesar 0,727 dengan Indeks gamma (γ) 0,296. Berdasarkan hasil penilaian tersebut terlihat masih adanya gap infrastruktur dari dan menuju simpul transportasi di kawasan pariwisata. Berbagai upaya mendorong peningkatan konektivitas harus diprioritaskan dengan penambahan jaringan jalan (dan jembatan), perbaikan kualitas perkerasan jalan serta serta lebar jalan. Pengelola kawasan wisata maupun pemerintah daerah setempat dapat bekerja sama dengan masyarakat setempat untuk menyediakan transportasi pendukung tersebut dengan memperhatikan kenyamanan dan keselamatan wisatawan.
THE IMPACT OF UKRAINIAN MIGRATION ON THE ECONOMIC DEVELOPMENT OF UKRAINE AND POLAND
Authors:   Chernihiv Polytechnic National University, Polkovnychenko Svitlana , Salai Ivan ,   Chernihiv Polytechnic National University
Published: April 2023

The work is devoted to the study of the impact of migration processes of Ukrainians to Poland on the development of the two countries. Based on the study of scientific sources and the authors' own re-search, the reasons of Ukrainian migration on the Polish vector are summarized in the form of Ishikawa diagram. The reasons for the migration of Ukrainians to Poland are classified by economic, political, social and professional aspects. The current state of migration of Ukrainians to Poland is analyzed using official Polish statistics, sociological research, as well as a survey of Ukrainian migrants conducted by the authors. Two main aspects of migration processes in the Ukrainian-Polish direction are identified: migration with the purpose of employment and education. An annual growth of the number of Ukraini-ans obtaining a work permit in Poland; employment of Ukrainian migrants in various spheres of the Polish economy; rejuvenation of Ukrainian migration; increasing popularity of Polish universities among Ukrainian graduates; increasing share of people who want to integrate into Polish society was detected. The impact of migration processes on the economic development of Ukraine and Poland has been assessed. Both positive and negative consequences for both countries are highlighted. Positive im-pact for Ukraine is an increase in money transfers, reduction of unemployment, return of part of the la-bor force with new knowledge and experience; while positive income for Poland is GDP growth, accel-eration of economic development, filling vacancies, stimulation of consumer demand, reduction of the average market rates of wages, supporting the development of educational institutions. Ukrainian econ-omy is negatively affected in the form of a slowdown in economic development, loss of valuable labor potential, sectoral asymmetries in the labor market, additional government spending on training new professionals, etc.; while in the Polish economy, the probability of unemployment rate growth increases, competition increases between migrants and the local population, who start looking for work in another country, conflicts may arise, etc. Measures aimed at improving the regulation of migration processes to deter emigration and return of migrants, which are consolidated by the areas of change in the country, stimulating business, stimulating workers, are justified.
THE RISK OF THE FUNCTIONING OF INSURERS AND THE TRUST OF INSURERS IN THE CURRENT MEASURE
Authors:   Kyiv National Economic University named after Vadym Hetman, Lieka Tetiana
Published: April 2023

The article deepens the understanding of the interdependence of the risks of insurance compa-nies. It is substantiated that in the most general view, the risks of insurers include the following types: strategic, tactical and operational. The specificity of the functioning of insurance companies leads to the emergence of insurance, market, credit and operational risks. It has been proven that risk is close-ly related to management, and the effectiveness of its management is the basis for the formation of a certain level of customer trust. The understanding of trust as an asset of the insurance company has been deepened. The relationship and interdependence between the riskiness of the functioning of in-surers and the trust of policyholders is substantiated. A generalized format of the insurer's business model is presented, taking into account the concepts of riskiness and trust.
FEATURES OF THE APPLICATION OF MARKETING TOOLS IN THE SPHERE OF ENTERTAINMENT SERVICES AT THE INITIAL STAGES OF PROJECT IMPLEMENTATION UNDER THE CONDITIONS OF DIGITALIZATION
Authors:   Chernihiv Polytechnic National University, Zabashtanska Tatiana , Remnova Lyudmyla ,   Chernihiv Polytechnic National University, Murai Alyona ,   Chernihiv Polytechnic National University
Published: April 2023

In the article, using the example of the virtual reality club «Dive VR», the peculiarities of the use of marketing tools at the initial stages of the project in the field of entertainment services in the conditions of digitalization are considered. The role and types of advertising means in the implementation of entertain-ment projects are considered. It was determined that advertising is a complex of all types of promotion methods, each of which has a unique set of approaches to delivering information to the consumer. Modern marketing tools that can be used to advertise services are analyzed. Internet advertising trends in Ukraine were studied and their dynamics were analyzed. It has been studied that the volume of promotion of adver-tising on the Internet, as one of the key directions of its placement, is growing in Ukraine. It has been stud-ied that in general, the online advertising market has been growing since 2021, when due to the COVID-19 pandemic, the peak of the demand for online advertising fell not only in Ukraine, but also in the whole world. In 2023, the Ukrainian online media market is expected to grow by an average of 8% due to in-creased demand for online media advertising in the context of digitalization.The peculiarities of the implementation of projects in the field of entertainment services were determined using the example of the virtual reality club «Dive VR» and the introduction of theSMM-marketer position was proposed as the basis for successful promotion of the club in the city of Cher-nihiv. The economic efficiency of this project has been analyzed and the key benefits that «Dive VR» club can get by hiring an SMM-marketer have been identified: «Dive VR» club's image will improve and its revenue will increase.Marketing in social networks is one of the most effective ways of online advertising in the mod-ern world, because most Ukrainians are active participants in social networks, which directly proportionally influence their choice of services, entertainment or goods.At the same time, each effectively organized project contributes to ensuring the stability of the functioning of the sphere of entertainment services
THEORETICAL ASPECTS OF THE INNOVATIVE STRATEGY FORMATION FOR THE ENTERPRISES’ DEVELOPMENT UNDER THE DIGITAL TECHNOLOGIES’ ERA
Authors:   Chernihiv Polytechnic National University, Popelo Oleksandr , Olyfirenko Ivan ,   Chernihiv Polytechnic National University
Published: April 2023

The article is devoted to the theoretical aspects and provisions of the process of forming an in-novative strategy for the development of enterprises in the era of digital technologies. The following main approaches to understanding the concept of "innovation strategy" have been studied and high-lighted. The classification features of the innovation strategy are systematized, within which their types are singled out and their characteristics are provided. It was found that the innovative strategy of the enterprise's development is shaped by such leading factors as the enterprise's competitive posi-tion, the degree of product uniqueness, the level of innovation potential, etc. The main properties of the innovation strategy are formulated, which include: the formation of a portfolio of innovations that meets the strategic goals of the innovative development of enterprises, taking into account the strate-gic space, the correspondence of the portfolio of innovative projects to market needs, the unification of functional development strategies, as well as permanent cooperation between the employees of the enterprise. The process of forming an innovative strategy for the development of the enterprise has been developed and the consequences of its implementation in the conditions of the spread of digital technologies have been outlined. The authors are convinced that in order to form an innovative strategy for the development of the enterprise, it is necessary to form a unique action plan in terms of managing the innovative activities of the enterprise, take into account the state and regional innovation strategy and coordinate these steps both with the strategies for the development of types of activities and with other business entities.The article examines that the rapid transformation of the economic system and the intensity of changes leads, on the one hand, to the appearance of new threats and challenges, and on the other hand, to the newest opportunities in the business environment, which requires the study of new theoretical foundations and conceptual approaches to the formation of an innovative strategy development of the enterprise.
Aneurysmal subarachnoid hemorrhage in a patient with dual autoimmune disorders. Perioperative challenges and management
Authors: Burman Sourav , Khandelwal Ankur , Mishra Amiya Kumar , Tripathy Laxmi Narayan
Published: April 2023

Autoimmune disorders (AIDs) are known to be associated with intracranial aneurysms; however, the coexistence of dual AIDs is a rare entity. Perioperative neuroanesthetic management of aneurysmal subarachnoid hemorrhage (aSAH) is typically complicated and challenging in such patients. In this report, we describe the successful management of a case of aSAH complicated by coexistent multiple sclerosis and systemic lupus erythematosus. A multidisciplinary team approach is warranted to manage such complicated cases.
Chemical Shrinkage Characterization during Curing through Three-Dimensional Digital Image Correlation
Authors: Bukenya Kalima , Shah Sagar , Sabato Alessandro , Maiaru Marianna
Published: April 2023

Chemical shrinkage in thermosetting polymers drives residual stress development and induces residual deformation in composite materials. Accurate characterization of chemical shrinkage during curing is therefore vital to minimize residual stresses through process modeling and optimize composite performance. This work introduces a novel methodology to measure the pre- and post-gelation chemical shrinkage of an epoxy resin using three-dimensional digital image correlation (3D-DIC). Differential scanning calorimetry (DSC) is employed to calculate reaction kinetics and correlate chemical shrinkage with the degree of cure. Rheology experiments are conducted to quantify gelation and validate post-gelation. 3D-DIC post-gelation results show excellent agreement with rheology. Pre-gelation results show the effect of the in-situ curing in the proximity of constraints on the global strain behavior. This work introduced an innovative approach to characterize the chemical shrinkage of thermosets during curing, which will enable accurate residual stress prediction for enhancing thermoset composite performance and provide insight into the in-situ polymer behavior during processing.
El amparo informático
Authors: Blume Fortini Ernesto
Published: April 2023

No presenta resumen
Bullous Lichen Planus of Oral Mucosa: A Case Report
Authors: Patel GB Varsha , Shetty Ranjani , L Ashok
Published: April 2023

Oral bullous lichen planus is a rare form of lichen planus LP characterized by vesicles or bullae which frequently occur in the setting of pre-existing LP lesions. Histopathology corroborates the diagnosis which is based on clinical suspicion. Bullous lichen planus does not have a standard therapy. Dapsone acitretin topical and systemic corticosteroids are a few of the efficient options. A case of oral bullous lichen planus in a 36- year old female patient with extra oral lesions on the legs successfully treated with topical Triamcinolone acetonide is described here in this case report.
Proteomic analysis reveals microvesicles containing NAMPT as mediators of radioresistance in glioma
Authors: Panizza Elena , Regalado Brandon D , Wang Fangyu , Nakano Ichiro , Vacanti Nathaniel M , Cerione Richard A , Antonyak Marc A
Published: April 2023

Tumor-initiating cells contained within the aggressive brain tumor glioma (glioma stem cells, GSCs) promote radioresistance and disease recurrence. However, mechanisms of resistance are not well understood. Herein, we show that the proteome-level regulation occurring upon radiation treatment of several patient-derived GSC lines predicts their resistance status, whereas glioma transcriptional subtypes do not. We identify a mechanism of radioresistance mediated by the transfer of the metabolic enzyme NAMPT to radiosensitive cells through microvesicles (NAMPT-high MVs) shed by resistant GSCs. NAMPT-high MVs rescue the proliferation of radiosensitive GSCs and fibroblasts upon irradiation, and upon treatment with a radiomimetic drug or low serum, and increase intracellular NAD(H) levels. Finally, we show that the presence of NAMPT within the MVs and its enzymatic activity in recipient cells are necessary to mediate these effects. Collectively, we demonstrate that the proteome of GSCs provides unique information as it predicts the ability of glioma to resist radiation treatment. Furthermore, we establish NAMPT transfer via MVs as a mechanism for rescuing the proliferation of radiosensitive cells upon irradiation.
Rapid and precise genotyping of transgene zygosity in mice using an allele-specific method
Authors: Yang Jianqi , DeVore Alison N , Fu Daniel A , Spicer Mackenzie M , Guo Mengcheng , Thompson Samantha G , Ahlers-Dannen Katelin E , Polato Federica , Nussenzweig Andre , Fisher Rory A
Published: April 2023

Precise determination of transgene zygosity is essential for use of transgenic mice in research. Because integration loci of transgenes are usually unknown due to their random insertion, assessment of transgene zygosity remains a challenge. Current zygosity genotyping methods (progeny testing, qPCR, and NGS-computational biology analysis) are time consuming, prone to error or technically challenging. Here, we developed a novel method to determine transgene zygosity requiring no knowledge of transgene insertion loci. This method applies allele-specific restriction enzyme digestion of PCR products (RE/PCR) to rapidly and reliably quantify transgene zygosity. We demonstrate the applicability of this method to three transgenic strains of mice (AtmTgC3001L,Nes-Cre, andSyn1-Cre) harboring a unique restriction enzyme site on either the transgene or its homologous sequence in the mouse genome. This method is as accurate as the gold standard of progeny testing but requires 2 d instead of a month or more. It is also exceedingly more accurate than the most commonly used approach of qPCR quantification. Our novel method represents a significant technical advance in determining transgene zygosities in mice.
EZH2 controls epicardial cell migration during heart development
Authors: Jiang Haobin , Bai Lina , Song Shen , Yin Qianqian , Shi Anteng , Zhou Bin , Lian Hong , Chen Houzao , Xu Cheng-ran , Wang Yanchun , Nie Yu , Hu Shengshou
Published: April 2023

Enhancer of zeste homolog 2 (EZH2) is an important transcriptional regulator in development that catalyzes H3K27me3. The role of EZH2 in epicardial development is still unknown. In this study, we show that EZH2 is expressed in epicardial cells during both human and mouse heart development.Ezh2epicardial deletion resulted in impaired epicardial cell migration, myocardial hypoplasia, and defective coronary plexus development, leading to embryonic lethality. By using RNA sequencing, we identified that EZH2 controls the transcription of tissue inhibitor of metalloproteinase 3 (TIMP3) in epicardial cells during heart development. Loss-of-function studies revealed that EZH2 promotes epicardial cell migration by suppressing TIMP3 expression. We also found that epicardialEzh2deficiency–induced TIMP3 up-regulation leads to extracellular matrix reconstruction in the embryonic myocardium by mass spectrometry. In conclusion, our results demonstrate that EZH2 is required for epicardial cell migration because it blocksTimp3transcription, which is vital for heart development. Our study provides new insight into the function of EZH2 in cell migration and epicardial development.
Small vault RNA1-2 modulates expression of cell membrane proteins through nascent RNA silencing
Authors: Alagia Adele , Tereňová Jana , Ketley Ruth F , Di Fazio Arianna , Chelysheva Irina , Gullerova Monika
Published: April 2023

Gene expression can be regulated by transcriptional or post-transcriptional gene silencing. Recently, we described nuclear nascent RNA silencing that is mediated by Dicer-dependent tRNA-derived small RNA molecules. In addition to tRNA, RNA polymerase III also transcribes vault RNA, a component of the ribonucleoprotein complex vault. Here, we show that Dicer-dependent small vault RNA1-2 (svtRNA1-2) associates with Argonaute 2 (Ago2). Although endogenous vtRNA1-2 is present mostly in the cytoplasm, svtRNA1-2 localises predominantly in the nucleus. Furthermore, in Ago2 and Dicer knockdown cells, a subset of genes that are up-regulated at the nascent level were predicted to be targeted by svtRNA1-2 in the intronic region. Genomic deletion of vtRNA1-2 results in impaired cellular proliferation and the up-regulation of genes associated with cell membrane physiology and cell adhesion. Silencing activity of svtRNA1-2 molecules is dependent on seed-plus-complementary-paired hybridisation features and the presence of a 5-nucleotide loop protrusion on target RNAs. Our data reveal a role of Dicer-dependent svtRNA1-2, possessing unique molecular features, in modulation of the expression of membrane-associated proteins at the nascent RNA level.