bluuebunny/crossref_metadata_2025 huggingface dataset:
Gilmar, homem semente
Authors: De Souza Maria de Lourdes Macena
Published: December 2021

Este trabalho compartilha aspectos sensíveis do homem, professor, pesquisador Gilmar de Carvalho na partilha de seus estudos e conhecimentos. Busca dar ênfase a teia rizomática de como, de forma simples e includente, ele foi geminando o reconhecimento das culturas populares, dos seus detentores e produtores desses saberes. O artigo traz o olhar de uma artista docente cearense cujas relações com Gilmar foram sempre presentes na luta constante pelos saberes tradicionais, buscando dar visibilidade aos sertões invisíveis e/ou zonas periféricas desses Cearás, por meios comunicacionais e/ou educacionais. No percurso metodológico, utilizei uma pesquisa exploratória em meus laços afetivos com sua obra, numa descritiva de abordagem qualitativa, de como cada uma delas se relacionam a tudo o que sei e faço como artista docente atuante.  O resultado trouxe vários encontros dessa profissional mulher, flor de Gilmar, em momentos sensíveis de eterna aprendizagem e gratidão. Estes encontros que ora promovo por meio deste trabalho trouxe-me um Gilmar vivo, presente, atuante, por meio de todo o legado que nos deixou, confirmando mais uma de suas teses: de que é possível permanecermos vivos por meio do que está perpetuado pela escrita. Espero que este possa também sensibilizar a todos e a todas para ver o homem semente Gilmar para além do profissional.
Modo online ativado:
Authors: Barbosa Lemos Ariane
Published: December 2021

Este artigo apresenta levantamento sobre a realização de eventos audiovisuais realizados na modalidade virtual, devido à pandemia de Covid-19. O recorte refere-se ao contexto brasileiro, mais especificamente a projetos culturais sediados em cidades do estado de Minas Gerais, no ano de 2020. A principal técnica de coleta de dados empregada foi a disponibilização de um formulário virtual, contendo perguntas abertas e fechadas. Participaram do estudo sete dos onze projetos culturais selecionados para a amostra. Os achados podem ser relacionados a três frentes: (1) desafios de adaptar toda a programação idealizada para o formato presencial e ofertada na modalidade virtual; (2) ganhos de acesso remoto de novos públicos; (3) tendência para edições futuras em um formato híbrido.
Contribuições para pensar as relações estabelecidas entre documentaristas e líderes-comunicadores folk
Authors: Postali Thífani
Published: December 2021

O trabalho estuda as relações estabelecidas entre documentaristas e líderes comunicadores folk, identificando se as relações representadas são resultantes de uma ética dialógica, à luz da filosofía buberiana e da folkcomunicação. A pesquisa busca refletir sobre as relações entre quem produz documentário e quem é filmado, pelo fato de a mídia brasileira representar, muitas vezes, de maneira generalista as sujeitas e sujeitos periféricos. Como metodologia, o trabalho faz uso de pesquisa bibliográfica e análise fílmica descritiva sobre os documentários brasileiros Fala Tu (2003) e Aqui Favela: o rap representa (2003). A escolha dos filmes se dá pela diferença na abordagem sobre os hip hoppers e pela proximidade na realização da produção. Assim, buscou-se com este trabalho refletir, especificamente, sobre as relações (ética, não ética) possíveis de serem identificadas nas produções de filmes documentários, entretanto, os apontamentos cabem para outras mídias que prometem asserções sobre o mundo histórico.
A folkcomunicação imagética de Sebastião Salgado no retrato de políticas sociais e ambientais
Authors: Renó Denis Porto , Furlan Lívia Maria de Oliveira
Published: December 2021

O discurso folkcomunicacional é amplamente diversificado. Afinal, ela se estabelece onde e quando os grupos marginalizados têm necessidade de voz. Entretanto, quando se pensa em folkcomunicação, tende-se a projetar tais discursos a manifestações tradicionalmente populares. Por isso, desenvolvemos este artigo, que tem como objetivo posicionar a fotorreportagem como um discurso folkcomunicacional, colocando o fotógrafo como agente folk. Para tanto, analisamos o contrato de leitura de Sebastião Salgado em duas de suas obras - Êxodos e Gênesis -, com um cariz formativo e reflexivo sobre o fotógrafo. Espera-se, com a conclusão deste artigo, que novos olhares sejam lançados aos fotorrepórteres, que ocupam através da imagem a função de tradutor do povo.
CYBER SECURITY STRATEGIES FOR HIGHER EDUCATION INSTITUTIONS
Authors:   Technical University of Moldova, Alexei Arina
Published: December 2021

Due to the large volume of data they manage, Higher Education Institutions (HEIs) are perfect targets for cyber attackers. University networks are open in design, decentralized and multi-user, making them vulnerable to cyber-attacks. The purpose of this research paper was to identify which is the recommended cyber security strategy and how comprehensive are these studies, within HEIs. The method proposed by Kitchenham was used, focused on the information community. Thus, the following results can be communicated: researchers recommend their own security strategies, because the standards analysed in the papers are not oriented on HEIs, and require important adjustments to be implemented. Most scientific papers do not describe risk management process. The implementation phases are also insufficiently analysed. The functions that the strategy addressed by HEIs should fulfill include identification, protection and detection. The validation methods used in the preimplementation and post-implementation phases are case studies and surveys. Most researchers recommend as final cyber security strategy IT Governance and security policies. The field of research has proved to be very interesting, the researches could contribute to the creation of a comprehensive cybersecurity strategy, focused on the specifics of HEIs, efficient, easy to implement and cost-effective.
PHYSICOCHEMICAL CARACTERISTICS OF UNRIPE APPLES
Authors:   Technical University of Moldova, Crucirescu Diana
Published: December 2021

Apple plays an important role in human health. The unripe apples, after physiological falls and the agricultural operation "regulation of the fruit load", are not used for food. The use of agricultural organic waste is a current problem. In the presented paper was approached the possibility of valorification on these unripe fruits to obtain natural products. Were studied the unripe apples of 4 varieties: Coredana, Golden Rezistent, Rewena and Reglindis. The fruits were harvested during development at 45th, 58th, 71st, 84th and 97th days after the full bloom. It was determined physico-chemical indices in fruits extracts. During the ripening of fruits, the diameter and mass increased continuously, the moisture content does not change significantly, but the pH values of the apple pulp increased nonessential. Dry matter content and total sugar increased considerably as the fruits were growing. There are unexpected increases in dry matter around the 84th day after the full bloom. The acidity decreased during the fruit development. Sensory evaluation was also effectuated. The results obtained provide informations regarding the optimal use of the unripe apple varieties researched in order to process and obtain different products (especially natural acidifiers).
PERSPECTIVES OF THE TRANSITION TO THE DIGITAL ECONOMY IN EU
Authors:   University “Stefan cel Mare”, Suceava, Romania, Albu Angela , Albu Maria Sabina ,   University “Stefan cel Mare”, Suceava, Romania
Published: December 2021

The Fourth Industrial Revolution or Industry 4.0 refers, in simple terms, to the way in which the technologies like artificial intelligence, autonomous vehicles, augmented reality and the internet of things are merging with the physical life of the people all around the globe. This new “era” is expected to transform in a revolutionary way the economies, employment and even the society in which we live today. The digital economy is very different in comparison to the traditional one and it is the result of the accelerated evolution of telecommunications, internet and electronics, and their integration in our everyday life. This arising economy is favoring the development of a new type of business, i.e. e-business. The process of the transformation of the actual economy in a digital one needs a set of favorable factors and a period of time, named period of transition. In this context, it is necessary to understand and to assess how advanced the transition process is in each EU country so that to be able to create and implement the suitable strategies who will lead to the digital economy. At EU level it was create an index - Digital Economy and Society Index (DESI) – with the aim to measure the progress of EU countries towards a digital economy and society. Our paper presents this index and make a comparative analysis of its evolution during the last 5 years. The results show an intense preoccupation of all EU countries for the improvement of the sectors considered in the calculation of DESI and the progress made by some states in this field.
Hydrogeophysical Implication of Geoelectric Sounding at Igarra Comprehensive High School, Akoko Edo Local Government, Nigeria
Authors: Adegoke Adediran Olanrewaju , Olafisoye E. Rotimi , Ologe Oluwatoyin
Published: December 2021

Electrical resistivity method was used to carry out hydrogeophysical study in order to evaluate the groundwater potential of Igarra Comprehensive High School, Akoko Edo Local Government, Nigeria. The vertical electrical sounding technique (VES) was adopted for the resistivity method. A total of eighteen electrical soundings were conducted across the area using the Schlumberger electrode array with AB/2 varying from 1 to 65 m. After the data acquisition, interpretation was carried out qualitatively and quantitatively and the results were presented as sounding curves, tables, charts, maps and geoelectric sections. The generated geoelectric layers from the sounding curves revealed four geologic layers: the topsoil, the weathered layer, the partially weathered/fractured basement and the fresh basement with their resistivity values ranging from 129.1 to 956.4 -m, 6.8 to 1491.1 -m, 261.3 to 776.6 -m and 1515.6 to 2653.5 -m respectively. The overburden thickness in the study area varies from 5.5 to 23.5 m. The groundwater potential map enabled in the classification of the study area into: low, medium and high groundwater potential area. About 85% of the study area falls within the low groundwater potential rating while about 10% constitutes the medium groundwater potential rating and the remaining 5% constitutes high groundwater potential rating.

Keywords: Groundwater, overburden, electrical resistivity, basement, geoelectric sounding.
Cadaveric Study of Anatomical Variations of Renal Arteries
Authors: Chandrika Pitta Venkata , Jakka Lakshmi Durga
Published: December 2021

Introduction: Anatomical variations of renal artery are important to prevent complications during renal transplant surgery or renal angiography. Of this additional renal artery is the most common.
Materials and methods: The present study was conducted in 80 kidneys of 40 adult human cadavers in Department of Anatomy, Siddhartha Medical College, Vijayawada over a period of 4 years (2017 to 2021) during educational dissections.
Results: Accessory renal arteries are observed in the present study. Origins of these accessory renal arteries are noted along with their entry point into the kidneys. These results were compared with previous studies.
Conclusion: Prior knowledge of these variations is important to prevent complications during surgical and angiographic interventions.

Keywords: Renal arteries, Accessory renal artery, Aberrant renal artery, Upper pole, Lower pole, Hilum.
Response of Growth and Production of Red Ginger (Zingiber Officinale Rubrum Rosc.) to the Use of Compost as a Planting Media
Authors: Sijabat Octanina Sari , Juniarsih Triara , Sijabat Arnila Sari
Published: December 2021

Red ginger is a prima donna medicinal plant during this COVID-19 pandemic, because it can help the body's immunity. For this reason, a cultivation method that can increase production is needed. This study aims to see the effect of using compost on the production of red ginger plants. The study was conducted in April 2021 until it was completed. The results showed that the production of red ginger using oil palm empty fruit bunch compost media was higher than other compost media.

Keywords: Production, Red Ginger, COVID-19.
Prevention of Work-Related Musculoskeletal Disorders in Physiotherapist - A Review
Authors: Desai Ruchi G , Shah Manali K
Published: December 2021

Introduction: Healthcare professionals, especially those with in direct contact of patient are at the highest risk of work-related musculoskeletal disorders (WMSDs), physical therapists being one of them.
Aim: Our aim was to review current knowledge relating to the prevalence, risk factors and prevention of WMSDs among physiotherapists.
Method: Google Scholar and PubMed were searched for terms relating to WMSDs in Physiotherapists from inception to 2021.
Result: The prevalence of WMSDs among Physiotherapist was high, with the lower back as the most frequently affected followed most often by the neck, upper back and shoulders. Knee joint was commonly affected joint in lower extremity. Multiple risk factors have been found responsible for WMSDs in physiotherapist and some of them are modifiable.
Conclusion: Implementing preventive strategies for WMSDs in early stage of a physiotherapist’s career may help to prevent WMSDs and maintain good quality of treatment for patients.

Keywords: Pain, Musculoskeletal disorders, Ergonomics, Prevention.
RANCANG BANGUN SISTEM OTOMATISASI RAINWATER SYSTEM UNTUK PEMANFAATAN AIR HUJAN DI GEDUNG MENARA ASTRA
Authors: Setiawan Rohmat , Prasetiono Eko , Khaeladien Elanza
Published: December 2021

Menara astra merupakan gedung perkantoran milik salah satu anak perusahaan dari PT Astra International Tbk, yang dirancang untuk menjadi international grade A office dengan standard green building grade platinum yang merupakan grade tertinggi dari suatu grade gedung perkantoran. Dalam memperoleh peringkat tersebut, menara astra menerapkan beberapa parameter, antara lain efisiensi dan konservasi energi listrik, air, kualitas udara serta kenyamanan ruangan. Salah satu hal yang menjadi perhatian dalam menentukan peringkat green building grade platinum adalah penggunaan air besih. Tentunya gedung seperti menara astra membutuhkan sumber daya air yang cukup banyak. Penggunaan sumber daya air ini berpengaruh pada kelangsungan air bersih yang semakin langka. Oleh karena itu dilakukanlah penelitian lebih lanjut dan didapatkan solusi untuk penggunaan air hujan dengan merancang bangun sistem otomatisasi pada rainwater system yang ada pada menara astra. Otomatisasi ini dilakukan dengan memasang water level control pada tangki air, hal ini bertujuan agar rainwater system dapat berjalan secara otomatis dan dapat mengurangi penggunaan air PDAM. Berdasarkan hasil yang telah dilakukan pihak perusahaan dapat menghemat penggunaan air PDAM hingga 35% dari pemakaian air biasanya
ANALISIS PERKUATAN DAN PENANGANAN TIMBUNAN BADAN JALAN TOL TRANS SUMATERA SEKSI V PEKANBARU-DUMAI DENGAN STRUKTUR PILE EMBANKMENT
Authors: Laventina Reinata Avhycanti , Setiawati Kartika
Published: December 2021

Jalan Tol Trans Sumatera Pekanbaru-Dumai merupakan ruas jalan tol utama karena digunakan untuk mobilisasi dan bisnis kota Pekanbaru-Dumai. Timbunan pada badan Jalan Tol Trans Sumatera merupakan faktor penting untuk struktur geoteknik di sekitar lereng yang berada di badan jalan tol. Timbunan tanah pada badan jalan tol digunakan untuk pencapaian elevasi akhir subgrade tanah. Pengaruh analisis stabilitas lereng serta penurunan konsolidasi tanah sangat berpengaruh pada analisis struktur geoteknik untuk timbunan tanah. Permasalahan yang terjadi adalah terjadi penurunan yang disertai kelongsoran sebagian lebar badan jalan di STA 79+ 615. Jalan Tol Trans Sumatera Seksi V Pekanbaru-Dumai dan box culvert tanah dasar mengalami penurunan. Kerusakan yang terjadi pada kedua lokasi berupa penurunan disertai retakan arah jalan dengan pergeseran tanah kearah samping (longsor). Analisis terhadap sisi geoteknik menggunakan perkuatan salah satunya menggunakan struktur pile embankment. Pada analisis perkuatan dan penanganan timbunan menggunakan struktur pile embankment akan dilakukan analisis faktor keamanan timbunan jalan. Parameter perkuatan dan penanganan timbunan tanah (sudut geser dalam, poisson ratio, kohesi, modulus elastisitas, dan muka air tanah) dapat digunakan untuk analisis struktur geoteknik berikutnya. Analisis perkuatan akan menggunakan aplikasi Plaxis (program analisis geoteknik dengan basis finite element method). Direncanakan untuk pile embankment dengan tipe spun pile dapat mencapai nilai safety factor 1,5 (faktor keamanan terhadap stabilitas global minimum SNI 8460-2017) dan mencapai nilai safety factor 1,1 (faktor keamanan terhadap beban gempa SNI 8460-2017) dengan dimensi spun pile diameter 60 cm, panjang efektif 10-12 meter dengan jarak spasi antar spun pile adalah 3 meter, dan tebal LTP (Load Transfer Platform) sebesar 1,8 meter.
IMPLEMENTASI METODE K-NEAREST NEIGHBOR UNTUK PREDIKSI PENJUALAN KEMASAN SKINCARE PADA PT. UNIVERSAL JAYA PERKASA
Authors: Muhammad Rino Indra , Nainggolan Esron Rikardo , Putra Jordy Lasmana , Sidik Sidik , Susafa'ati Susafa'ati , Radiyah Ummu
Published: December 2021

PT. Universal Jaya Perkasa merupakan perusahaan yang bergerak dalam industri kemasan skincare. Perusahaan ini memiliki berbagai jenis kemasan skincare yang ditawarkan. Kendala yang dialami perusahaan yaitu belum adanya suatu metode dalam menentukan prediksi penjualan pada setiap produk di PT. Universal Jaya Perkasa dan belum adanya akurasi yang tepat dalam melihat penentuan suatu prediksi penjualan produk sehingga terjadi penumpukkan barang yang tidak terjual sesuai target perusahaan. Maka dibutuhkan prediksi untuk penjualan produk kemasan skincare yang paling banyak diminati setiap bulannya, yang berguna untuk mempermudah pihak perusahaan dalam perencanaan penyediaan stok produk. Untuk mengetahui penjualan produk kemasan skincare yang paling banyak diminati digunakan teknik klasifikasi data mining dan algoritma K-Nearest Neighbor menggunakan tools Rapidminer. Hasil perhitungan data mining menggunakan teknik klasifikasi dan algoritma K-Nearest Neighbor, terdiri dari atribut Kategori Produk, Kuantitas dan Bulan. Didapatkan hasil prediksi penjualan tertinggi pada produk kemasan skincare dengan 7 kategori produk yaitu Lipgloss Tube pada bulan (Juli & Maret), Cream Bottle (Februari), Essential Oil Bottle (Oktober), Spray Bottle (September), Powder Box (Januari), Pump Bottle (Agustus & Oktober) dan Tube (Agustus & Desember). Hasil pengujian perhitungan akurasi menggunakan Rapidminer untuk mengetahui penjualan beberapa bulan mendatang diperoleh hasil nilai akurasi 80%.
Syntactical semantics and its impact on tuḥfaẗ al-āaḥwaḏī a commentary of tirmiḏī by Abdur–Rehman al Mubarakpuri (1353A.H)
Authors: اختر رقية
Published: December 2021

This ariticle aims to explain Syntactical semantics and its impact on tuḥfaẗ al-āaḥwaḏī a commentary of tirmiḏī by Abdur–Rehman al Mubarakpuri (1353A.H). he was a great Indian scholar particularly in the field of  Hadith and its sciences,the book  tuḥfaẗ al-āaḥwaḏī is a well known commentary and living proof of the expertise of Mubarak poori in the said field. The author wrote an intellectual and useful introduction of Sunan tirmiḏī and the rules applied by imam tirmiḏī in the narration of Prophetic tradition, likewise, he has explained the worth of sunan tirmiḏī in the field of Hadith.

The method of abdur Rahman Mubarakpuri in this commentary is that he mentions the differences of different school of thoughts of Arabic   grammarians in grammatical issues along with preferred opinion,    for example he describes first the opinions and intellectual basis of kūfiyin , baṣriyin etc, then he discussed in detail the merits and demerits and gives preference to one of them.,
Metamorphosis of Aesthetic Visual Culture, an Aftermath of War
Authors: Mamoona Khan
Published: December 2021

Creative brains are kept only by sensitive creatures, and the most empathetic are of those associated with visual arts fields, affected even by a minor stir in their surroundings, which is reflected in their creative endeavours. They sub consciously interpret their time. Unpleasantness of war or situations analogous to war have always left a negative mark on their aesthetic interpretations.  History is replete with such examples. But the most stunningly heinous transgressions were exercised by modern mechanisms of war that violated ethics par human perception. The era shattered beliefs of man on humanitarian values. It also caused transformation in the field of aesthetics which is beyond human comprehension. The metamorphosis was so rapid that it brought aesthetics and beauty at antithetical stages, which led the French artist Paul Duchamp to display a urinal as a piece of sculpture in an art exhibition. Hence, weirdness replaced beauty; logical delineations substituted the abstruse, and crafty ousted the artistic, still protected under the umbrella of art. It is labelled as modern, subjective or abstract but not viewed as a repercussion of war trauma. The paper will be exploratory research to probe reasons behind the apparently unreasoned transformations delineated through art. Modern art specimens of post-war era along with those resulted from a few chaotic situations will be analysed to draw conclusions. It will be based on deductive methods of reasoning to scrutinise history, psychology and the field of art in order to comprehend the impact and reactions of war trauma on sensitive souls of artists that led them to transform the entire visual field of aesthetics.
Anti-inflammatory effect of Sustained release granules of Aceclofenac in Gouty Arthritis Rat
Authors: Kumar Rajiv , Nain Parminder , Kaur Jaspreet , Kumar Dhawan Ravi
Published: December 2021

Gout is most common painful clinical syndrome occurs due to hyperuricaemia (high serum uric acid level) and deposition of monosodium urate crystals in joints. In the current experimental study, the anti-inflammatory effect of sustained release granules of aceclofenac, was investigated on monosodium urate crystal-induced inflammation in rat. Monosodium urate is injected appropriately at a dose of 3 mg/kg body weight of a rat on right ankle to induce inflammation in joint like gouty arthritis. The percentage of joint swelling in positive control group was increased significantly (p<0.5) when compared with normal group after 1 hr, 12 hr and 24 hr with a single injection of MSU. Therapeutic effect of sustained released granules (OD) is similar to conventional released granules (BD) and possesses an anti-inflammatory effect, which could provide relief in gouty arthritis after administration of sustained release formulation of aceclofenac once in a day only. The current study clearly indicated that slow release granules of aceclofenac exerted a strong anti-inflammatory effect against gouty arthritis at standard dose once daily. It concluded that, when aceclofenac tablet is formulated with slow release granules it decreases the dosing frequency with same therapeutic effect.
Synthesis and Biological Evaluation of Some Novel Pyrrole Derivatives
Authors: Bhardwaj Saurabh , Kumar Sharma Gyanendra
Published: December 2021

The Pyrrole is one of the significant classes of heterocyclic mixes having pharmacological and natural exercises, for example, antibacterial, antifungal, anthelmintic. The subbed pyrroles with chose functionalities at various position fill in as antecedents for the combination of different new functionalities. Pyrrole has additionally indicated wide organic exercises, for example, treatment of hyperlipidemias, mitigating, COX1/COX-2 inhibitors, 6 cytotoxic action against strong tumor model and assortment of marine and human models. A progression of new Schiff base (E)- N'- Substituted benzylidene-1H-pyrrole-2-carbohydrazide subsidiary (3a-3j) were combined by the response of 1H-pyrrole-2-carbohydrazide and fragrant aldehyde within the sight of ethanol with barely any drops of frosty acidic corrosive. The response blend was observed by TLC and recrystallized from wanted dissolvable. FTIR, 1HNMR, mass spectral and natural investigation were affirmed the structure of the blended mixes. All orchestrated mixes were screened against traditional strains for their antibacterial, antifungal and anthelmintic tasks: gram positive is B.subtilis, and S.aureus and gram negative are E. coli. Antifungal movement was screened against C. Albicans and A. niger and anthelmintic movement was screened against M. konkanensis and P. corethruses. The outcomes uncovered that 3f, 3g and 3i display increasingly strong action against the both two microorganism (gram negative and gram positive bacteria) on the opposite side compound 3a, 3g and 3h show progressively intense movement against the two growths (C. Albicans and A. niger) and compound 3c and 3d having most powerful movement with mean paralyzing time of 11.27 mins and 15.83 mins and mean death time of 19.25 mins and 24.45 mins individually when contrasted with standard medication.
Formulation and Evaluation of Solid Self-Nanoemulsifying Drug Delivery System for Enhancing the Solubility and Dissolution Rate of Budesonide
Authors: Prasad Kanuri Lakshmi , Hari Kuralla
Published: December 2021

Objective: To enhance solubility and dissolution rate of budesonide through development of solid self-nanoemulsifying drug delivery system (S-SNEDDS). Methods: Liquid self-nanoemulsifying drug delivery systems (L-SNEDDS) were prepared and ternary phase diagram was constructed using Origin pro 8. Liquid self-nanoemulsifying formulation LF2 having 20% oil and 80% of surfactant/co-surfactant was optimized from the three formulations (LF1-LF3) to convert in to solid, through various characterization techniques like self-emulsification, in vitro drug release profile and drug content estimation. The prepared L-SNEDDS converted into S-SNEDDS, SF1-SF6 by adsorption technique using Aerosil 200, Neusilin US2, and Neusilin UFL2 to improve flowability, compressibility and stability. Results: Formulation LF2 exhibited globule size of 82.4 nm, PDI 0.349 and Zeta potential -28.6 mV with drug indicating the stability and homogeneity of particles. The optimized formulation SF4 containing Neusilin UFL2 was characterized by DSC, FTIR, X-Ray diffraction studies and found no incompatibility and no major shifts were noticed. Formulation SF4 released 100 % drug in 20 min against pure drug release of 47 % in 60 min. Regardless of the form (i.e. liquid or solid) similar performance of emulsification efficiency is observed. Conclusion: The results demonstrated that the technique of novel solid self-nanoemulsifying drug delivery system can be employed to enhance the solubility and dissolution rate of poorly water-soluble drug budesonide.
Method Development and Validation for Pyrogallol Content Quantification by HPLC in Trimetazidine Dihydrochloride
Authors: Rapeti Durgababu , Venkata Narayanarao Kapavarapu Maruthi , Shyamala Pulipaka , Murali Krishna Rallabhandi
Published: December 2021

Trimetazidine dihydrochloride (TD) is an anti-ischemic drug that is used to effectively treat angina pectoris symptoms. During the manufacture of TD from gallic acid a process related impurity, pyrogallol, is produced. Up to the present time, no appropriate method has been proposed for the detection and analysis of pyrogallol in the TD at the level of threshold of toxicological concern. Therefore, in this investigation, a reliable and reproducible HPLC method was developed for the detection and analysis of pyrogallol in the TD. The method was validated in full compliance with the recommendations of the International Harmonization Council. Regression analysis indicated a correlation coefficient value of 0.9990 for pyrogallol between 6.3 ppm and 31.5 ppm. The LOD was 1.89 ppm and LOQ was 6.3 ppm for pyrogallol. Good recovery (accuracy) was observed in the range of 98.34% to 118.54 % with an RSD value (precision) of 0.150%. Pyrogallol analysis in batches TD material has demonstrated the good performance of the method. The process is therefore useful in the identification and evaluation of pyrogallol content in drug substance of TD.
Formulation and Optimization of Self Emulsifying Drug Delivery System For Effective Anthelmintic Therapy
Authors: Mahajan Kiran C. , Pimple Smita S. , Deokule Hemant A.
Published: December 2021

The present study aims to develop and optimize a self-emulsifying drug delivery system for paediatric patients to improve the oral bioavailability of the anthelmintic drug, Praziquantel (PZQ) and to perform it’s in-vitro dissolution study. The solubility of PZQ was estimated in various vehicles to select proper component combination. Capmul MCM (oil), Cremophore RH40 (surfactant) and PEG400 (co-surfactant) were employed to construct pseudo-ternary phase diagrams. Eight formulations composed of Capmul MCM, at Smix ratios (1:1, 2:1 & 3:1) were selected. The optimized formulation F7 has a mean globule size 14.73 nm with a negative zeta potential -44.43 mV. The results indicated that PZQ loaded SEDDS, showed enhanced solubilization and nanosizing potential to improve the absorption of the drug.
A Study of The Effect of Aminophylline on Clinical Recovery and Bis Readings After Total Intravenous Anesthesia
Authors: Kadhim Ghison I.
Published: December 2021

Background: In anesthesia and intensive care we face a lot of respiratory problems that require the use of bronchodilators such as aminophylline which is accused of antagonizing of the action of adenosine which acts as neuromodulator in the CNS. Objective: To test the hypothesis that aminophylline increases BIS readings and decreases recovery time after total intravenous anesthesia. Methods: We tested the hypothesis on 50 patients who were to be operated upon for orthopedic procedures. We induced anesthesia using bollous dose of propofol 2.5 mg/kg and bollous remifentanil 1.5 mcg/kg and didn't use any muscle relaxant. Anesthesia was maintained using propofol and remifentanil infusion in the rate of 100 mcg/kg/min and 0.2 mcg/kg/min respectively with 100% O2 with BIS readings in the range of 40 – 60. After skin closure, patients were divided into group A (given aminophylline 4 mg/kg), and group P (given same volume of normal saline). Vital signs and BIS values were recorded. Time to eye opening and extubation time and time to reach BIS value of 95 were measured. Results: Significant difference was found in BIS readings (p value < 0.001). Time to eye opening and extubation times were significantly shorter in group A than group P (p value < 0.001). Conclusion: Aminophylline decreases recovery time and increases BIS readings after TIVA.
Analysis of Fingerprint Patterns among Central Indian Population- A Cross Sectional Study
Authors: Nagrale Ninad , Ambad Ranjit , Patond Swapnil , Gawali Rohan
Published: December 2021

Background: A person's identity means understanding positively who a given individual is. Human identification is a universal method focused predominantly on finger printing and based on scientific principles.
Aims and objectives: To study of fingerprint patterns among Central Indian population. Material and Methods: This prospective study was carried out to determine the prevalence of the type of fingerprints in each finger and their gender distribution among 250 individuals of Central Indian origin comprising 125 males and 125 females. Results: The general distribution of fingerprint patterns in the present study is noted in the same order as defined in the literature. Largest loops (55.3%), moderate whorl (34.7%) and least arch (10.0%) respectively. It was found that loop (57.4 %) and arch (14.6 %) fingerprints were more prevalent in women than in men. In males (41.5 per cent), the Whorl fingerprint is more prevalent compared to females (28.0 per cent). Conclusion: The right hand shows typical fingerprints of the loop and whorl, and the arch fingerprint was more in the left hand.
Design, Synthesis and Antibacterial Activity screening of Novel Bis cyclic Imides Linked to Trimethoprim Drug
Authors: Hussein Fadel Zaynab , Al-Azzawi Ahlam Marouf
Published: December 2021

Cyclic imides are well known important organic compounds that exhibit diverse biological activities like anti - inflammatory, antibacterial, analgesic, hypoglycemic and antifungal activities. Besides these compounds are useful building blocks in the synthesis of many drugs and pharmaceuticals. On the other hand trimethoprim is a well-known antibiotic that is used in combination with Sulfamethoxazole in treating urinary tract infections, bacterial infections and acute invasive diarrhea. Moreover Schiff bases represent the most active intermediates that exhibit wide spectrum of biological activities and play a vital role in the production of different pharmaceutical and bioactive heterocycles. Based on all these facts, it seems worthwhile to design and synthesize new molecules that contain these three active moieties (cyclic imide, trimethoprim and Schiff base) together in the same molecule since this may exhibit the new compounds high biological activity and may open possibilities for fighting bacterial infections.
Simultaneous HPLC Method Development and Validation of Bilastine and Montelukast in Bulk and Formulation
Authors: Shinde Ankita , Gajeli G.B. , Ubale Sneha , Matole Vinod
Published: December 2021

A new, simple, rapid, selective, precise and accurate reverse phase high performance liquid chromatography assay has been developed for simultaneous estimation of Bilastine, and Montelukast in tablet formulations. The separation was achieved by using Phenomenax Kinetex XB C-18 column (150 x 4.6mm, 5 .) using mobile phase Methanol: 0.1% TFA water (80:20). Injection volume was 10µl. The flow rate was 1.0mL.min-1 and the separated drugs were detected using UV detector at the wavelength of 270nm. The retention time of Bilastine and Montelukast was noted to be 1.27, and 4.86 respectively, indicative of rather shorter analysis time. The method was validated as per ICH guidelines. The proposed method was found to be accurate, reproducible, and consistent. It was successfully applied for the analysis of these drugs in marketed formulations and could be effectively used for the routine analysis of formulations containing any one of the above drugs, or a combination, without any alteration in the chromatographic conditions.
Formulation and Evaluation of Fast Dissolving Tablet of Ondansetron by Utilizing Liquisolid Compact Technique
Authors: Jain Sanket , Pillai Sujit , Singh Mandloi Rampal , Birla Nikhlesh
Published: December 2021

Ondansetron is an anti-emetic drug which is insoluble in water. The present study was aimed to formulate and evaluate oral fast dissolving tablet of Ondansetron by Utilizing Liquisolid Compact Technique. The tablets were prepared by direct compression method and characterized by UV, FTIR studies. Six formulations (F1-F6) of ondansetron were prepared and tablets were evaluated for weight variations, hardness, thickness, friability, disintegration time, drug content and In-vitro dissolution studies gave satisfactory result. TF6 was found to be the best and acceptable formulation whose drug content was about 99.17±0.05 and percentage (%) drug release 97.49±2.03 in 10 min, high as compare to other formulation and has low disintegration time 17±0.01 as compare to other formulation which indicates that drug is rapidly dissolved and available at the site of action.
Effects of Curcumin in Management of Endometriosis a Hormonal Disorder Disease in Female
Authors: Savant Priti B. , Kareppa Manjusha S. , Shinde Akshata U.
Published: December 2021

A disorder in which endometrial tissues develop outer side the uterus or uterine cavity is called as endometriosis. It affects mainly females in their reproductive years, and is an oestrogen-dependent condition. Endometriosis a gynaecological disease or disorders, occurs in about 10% of female in reproductive age and in upto 50% of females with in-fertility. It is serious type of Hormonal disease or disorders in female which is caused due to hormonal imbalance these diseases totally change the quality of womens life. Decreased quality of life is the most significant predictor of direct health care and total costs so avoid this next step greater way to take care “Prevention is always better than cure”. Curcumin is a natural polyphenolic compound extracted from the spice, turmeric and has been reported to evidence anti-inflammatory (agent which reduce inflammation), antioxidant (the agent which reduce oxidation), and anti-proliferative properties via the modulation of multiple cellular. However, it remains to be determined whether effect of curcumin affects in the management of process of endometriosis. Turmeric contain especially its most active compound Curcumin have many scientifically proven health benefits, it’s a potent Anti-inflammatory and antioxidant and may also help improve symptoms of endometrosis.
Insanity of Kenya’s ‘Guilty but Insane’ Verdict
Authors: Kang'Ethe Mitchelle
Published: December 2021

A person may be insane while committing an unlawful act, leading them to raise the defence of insanity in court. This defence argues that the person’s illness prevented them from having the criminal intent needed to satisfy the mens rea requirement for criminal responsibility. The successful establishment of this defence in Kenya leads to the court issuing a special verdict of ‘guilty but insane’ (GBI). This verdict sees that the defendant is incarcerated in a place of safe custody where they can be treated for the illness that contributed to their commission of the offence. While isolation and treatment of the defendant form the primary aims of the verdict, this paper demonstrates that they are barely achieved in Kenya. This is because the conditions crucial to the verdict’s implementation–medication and therapy, a place of custody and the presence of psychiatrists–are wanting in the country. After examining the institutional barriers to the realisation of the verdict’s objectives, the paper studies various responses to these challenges by Kenya and Ghana. It finds solutions that promote the realisation of the verdict’s aims such as the provision of educational opportunities in forensic psychiatry.
Right of Appeal under Section 35 of the Arbitration Act of Kenya
Authors: Sebayiga Vianney
Published: December 2021

An arbitral award is final and binding on the parties but may be set aside for failure to adhere to due process requirements. Section 35 of the Arbitration Act (Act hereafter) provides grounds for setting aside an arbitral award. It does not state whether decisions of the High Court on setting aside an arbitral award are final and thus cannot be appealed. In Nyutu Agrovet Limited v Airtel Networks Limited, the Supreme Court interpreted Section 35 to allow appeals on High Court decisions of setting aside an arbitral award. This paper analyses the Supreme Court decision and finds that it abrogated the internationally recognised arbitration principles such as party autonomy, the finality of arbitral awards and limited court intervention. Additionally, the paper discusses the implications of the decision on arbitral practice in Kenya. Using literature review and comparative jurisprudence, it advances that Section 35 does not allow appeals on decisions of the High Court. To this end, it proposes better interpretation techniques to safeguard the sanctity of arbitral awards.
The Causal Impact of the Rapid Czech Interest Rate Hike on the Czech Exchange Rate Assessed by the Bayesian Structural Time Series Model
Authors: Bednar Ondrej
Published: December 2021

I have employed the Bayesian Structural Time Series model to assess the recent interest rate hike by the Czech Central Bank and its causal impact on the Koruna exchange rate. By forecasting exchange rate time series in the absence of the intervention we can subtract the observed values from the prediction and estimate the causal effect. The results show that the impact was little and time limited in one model specification and none in the second version. It implies that the Czech Central Bank possesses the ability to diverge significantly from the Eurozone benchmark interest rate at least in the short term. It also shows that the interest rate hike will not be able to curb global inflation forces on the domestic price level.
أثر القرآن الكريم و أئمة القراءة في حفظ اللغة العربية
Authors: عبد الكريم أحمد بدر الدين
Published: December 2021

أثر القرآن الكريم و أئمة القراءة في حفظ اللغة العربية

After the presentation and prefacing of the research topic, I followed talking about the impact of the Koran and the Imams of reading in the maintenance of the Arabic language and its development, and how it acquired the Arabic language the Holy Light and eternal True to the verse( Verily We have revealed the Holy Quran and We promise to keep it )AI Higgr:9.

.( Then dealt with based on scientific facts and historical monuments that show their efforts in keeping the Arabic language and its development and prosperity of the building and have even become etymological dictionaries more frequent and good in eloquence.

Then 1 pointed out with explanation and examples of how excellence and uniqueness and fluency in language is due to the descent of the Holy Quran and it has the impact of the great excellence of the tongue speakers and conservers of its bases in terms of voice, grammatical, morphological and rhetorical: and how this excellence was reflected on scientist's readings and intonation which created rules of morphological phenomena and this was not preceded by any new voice in the Arabic tongue or any other tongue
العلاقة بين الفقه الإسلامي و القانون الوضعي
Authors: حسن محمد الحسن الأمين
Published: December 2021

العلاقة بين الفقه الإسلامي و القانون الوضعي

This study aims at explaining the relation between Islamic jurisprudence and positive jurisprudence .The study showed the deference between the two :the second as man made and the first with its principles from the Quran and Sunnah.

The study is divided into an introduction, four chapters and a conclusion The researcher concluded with the most important results which are : There is no harm in taking from Expcrian from the applied technical rides of the jurisprudence, which doesn’t contradict with sharia principles
مسيرة انتشار الإسلام في غرب أفريقيا
Authors: جعفر خلف الله محمد شبو
Published: December 2021

مسيرة انتشار الإسلام في غرب أفريقيا

The research studies the long journey of the spread of Islam in western Africa and the problems that faced its peaceful penetration in it .These problems were relating mainly to the ways and means adopted in spreading Islam.

They were the strong links that tied Africans to their environment and the deeply rooted traditions.

The research detects the movement of spreading Islam since its commencement in the Vth century until the advent of the European colonization in the century describing the routes and the people who took part in that peaceful movement .

The research tackles the allegations raised by some European writers accusing Muslims of enforcing their religion by sword, the hateful slave trade and not contributing in developing the content .However, the research proved that those allegations were non-objective and false .They can only be read within the context of the colonial policy to convert African to Christianity .Indeed, they were an echo of the Medieval Crusades against Islam which has provided a better choice of culture for the Africans
إستراتيجية العلاقات العامة في نشر الوعي الصحي : دراسة تطبيقية على مرضى سرطان الأطفال بالخرطوم
Authors: منتصر سعد عمر الفكي
Published: December 2021

إستراتيجية العلاقات العامة في نشر الوعي الصحي : دراسة تطبيقية على مرضى سرطان الأطفال بالخرطوم

Hundred and twenty (120 ) children under the age of fifteen per million suffer from cancer annually in the Arab world and this percentage does not constitute more than the of the injured adults, although it needs attention to this phenomenon, and to do our utmost in the fighting against this disease to be avoided or to decrease it's effect, because children are all the future, so the importance of this study was to raise awareness of the fight against this disease.

The research aims at taking the role of public relations in charities'stsablish that deal with issues of childhood cancer patients' andin raising awareness to combat declarewar against this disease and to identify the programs carried out by public relations in the fight against this disease, .The study shows the exact of response to there programs and the means used by the establish with to cary at the against this decrease, the study shows some impact results
Pemetaan potensi usaha desa dan penerapan "Adwords" sebagai solusi menghadapi persaingan usaha pada BUMDes Bhuana Amertha Sari Desa Tampaksiring, Gianyar
Authors: Sumerta I Komang , Rai Anak Agung Gede
Published: December 2021

Bali has a lot of potential for strong local wisdom and culture as a provision in creating an alternative economy so that it relies not only on one tourism sector. One alternative is to develop Village Owned Enterprises (BUMDes). Based on the results of observations with the BUMDes administrator Bhuana Amerta Sari, Tampaksiring Village, Gianyar Regency, it was found that the business development managed by BUMDes Bhuana Amerta Sari, Tampaksiring Village, Gianyar Regency is still not optimal. In addition, management is still conventional, and product marketing is not optimal and has not implemented digital-based marketing in the face of increasingly fierce business competition. To overcome these problems, activities are designed that can answer the problems of partners, namely Bimtek and FGD of village potential in business development in the face of business competition. The results are various village business potentials that BUMDes can develop, mapping of village potential using SWOT analysis to measure the scale of business priorities.
Die Schule spricht
Authors: Pennitz Gudrun
Published: December 2021

Dieser Artikel ist aus Sicht der Schule verfasst: Die Schule spricht. Er setzt sich mit den Erwartungshaltungen und Forderungen seitens der Gesellschaft an die Schule auseinander und zeigt faktenbasiert deren Grenzen und Möglichkeiten auf.
Chancen geben und die Statistik verändern
Authors: Ebel Eva
Published: December 2021

Das Programm ChagALL („Chancengerechtigkeit durch Arbeit an der Lernlaufbahn“) am Gymnasium Unterstrass in Zürich unterstützt leistungsstarke und leistungswillige Jugendliche mit Migrationshintergrund aus Familien mit niedrigem sozioökonomischen Status, damit sie die Aufnahmeprüfung an einem Gymnasium, einer Berufsmittelschule oder einer Fachmittelschule bestehen, und begleitet sie nach bestandener Prüfung in der Probezeit und darüber hinaus. Dieses Programm ermöglicht ausgewählten Jugendliche eine statistisch gesehen eher unwahrscheinliche Schullaufbahn, entbindet aber nicht von der politischen Aufgabe, weiterhin bestehende Ungerechtigkeiten im Bildungssystem zu beheben.
Begabungen machen Schule
Authors: Purtschert Marietheres
Published: December 2021

Die beiden Schulen Oberägeri ZG und Rickenbach SZ betreiben seit vielen Jahren erfolgreich Begabungsförderung. Marietheres Purtschert, Lehrerin und Schulleiterin an beiden Schulen, berichtet über die Erfahrungen und Entwicklungen der beiden Schulen. Im Zentrum steht dabei die Potenzialentfaltung und Stärkenorientierung. Der Beitrag motiviert hoffentlich viele weitere Schulen sich auf dem Weg zu einer begabungsfördernden Schule zu begeben.