bluuebunny/crossref_metadata_2025 huggingface dataset:
NIENATURALNE AMINOKWASY JAKO STRATEGIA DO OTRZYMYWANIA SUBSTRATÓW, INHIBITORÓW I NISKOCZĄSTECZKOWYCH SOND AKTYWNOŚCI DLA ENZYMÓW PROTEOLITYCZNYCH
Authors: Poręba Marcin , Kasperkiewicz-Wasilewska Paulina , Rut Wioletta , Drąg Marcin
Published: January 2025

roteolytic enzymes are molecular scissors that are responsible for the amide bond breakdown in peptide and protein substrates. Over the years, the view on proteases has been considerably changed from non-specific digestive enzymes to sophisticated biocatalysts, which by performing limited proteolysis control virtually all biological processes. In order to better understand how proteases work and what are their biologically relevant target substrates, it is indispensable to determine their catalytic preferences. This knowledge can be further utilized to develop selective substrates, inhibitors and activity-based probes (ABPs) enabling the monitoring of proteases activity in various settings, from in vitro analysis on recombinant enzymes or cell lysates to ex vivo and in vivo imaging at the single cell level. Among many chemical-based approaches that have been developed and applied over the years, the Hybrid Combinatorial Substrate Library (HyCoSuL) technology has emerged as one of the most powerful one. HyCoSuL is a combinatorial peptide-based library of fluorogenic substrates, that comprise natural and unnatural amino acids, that can deeply explore the chemical space in proteases active site, providing a structural framework for the development of highly-selective chemical tools. In this review we present the most prominent examples of proteolytic enzymes that have been profiled with HyCoSuL approach yielding selective substrates, potent inhibitors, and very sensitive activity-based probes.
ASYMETRYCZNE REAKCJE PERICYKLICZNE KATALIZOWANE KOMPLEKSAMI MAGNEZU
Authors: Czombik Anna
Published: January 2025

II Group-metals, like magnesium, are one of the most widespread elements in the environment. The abundance of II-group metals in the Earth’s crust is over 108 times greater than the precious metals. For the industrial applications, the important factors are the low costs of production and higher accessibility of their compounds. This puts the spotlight on alkaline-earth metals competing with transition elements as catalysts in organic synthesis. Features of their derivatives, like mild Lewis acidity and strong Brønsted basicity enabled them to catalyze reactions where Lewis-acid- activation of the substrate is essential. In this review the emphasis was put on magnesium-catalyzed pericyclic reactions, which are recognized as one of the most important methods of new carbon-carbon or carbon-heteroatom bonds formation. Using the catalysts based on II-group metal cations and chiral ligands, a highly stereoselective conversion of achiral substrates into enantioenriched products is possible. The Mg-based catalysts have been used in Diels-Alder, ene and 1,3-dipolar additions. Described synthesis methods were characterized by high efficiency (chemical yields and enantiomeric excesses). Where applicable, the relationships between the structure of catalyst/substrates, conditions and efficiency were discussed. Just now there are a few applications, for example in synthesis of alkaloid (–)-manzacidine or antibiotic of algal origin – (–)-malyngolide.
O SIŁACH NAPĘDOWYCH W PRZYRODZIE – KONCEPCJE, INTERPRETACJE I NIEPOROZUMIENIA
Authors: Orlik Marek
Published: January 2025

Prepared for presentation within the Didactic Section of Polish Chemical Society, the study summarizes selected problems and concepts of teaching the basics of chemical reaction energetics as part of chemical undergraduate studies. The following problems are discussed: 1) indication of misunderstandings related to the definition of standard states in thermodynamics, with particular emphasis on the unfortunate assignment of the temperature of 298.15 K as "standard temperature", 2) problems with the interpretation of entropy as a "measure of disorder", with a recommendation regarding for understanding entropy as a measure of the number of ways to distribute the total energy of the system between the available degrees of freedom of motions, in terms of the quantum representation, i.e. the energy characteristics of a substance through sequences of energy levels, 3) a proposal to introduce the issue of thermodynamic driving forces of a chemical reaction based on the characteristics of the water evaporation process under different conditions, which favors the distinction of any reaction driving force from its standard driving force, as well as the distinction of such forces for isochoric and isobaric systems, both one- and multi-component, (4) the necessity to take into account the entropy of mixing of reagents to deepen the understanding of changes in the driving force of the reaction on the way to the state of chemical equilibrium, and 5) various interpretations of the influence of temperature on the equilibrium composition of the reacting system (Le Chatelier-Braun rule), with a recommendation for molecular interpretation, showing the role of differences in energies and sequences of energy levels of reactants and products for the value and direction of changes of the equilibrium constants of the reaction with temperature, taking into account also the principles of statistical thermodynamics. An additional aim of the article is to emphasize the importance of elementary mathematical education for mastering the basic laws governing the course of physicochemical processes, as well as for true understanding of chemistry, in general.
SIECI METALO-ORGANICZNE TYPU MOF JAKO PRZYKŁAD MATERIAŁÓW WYKORZYSTYWANYCH W UKIERUNKOWANEJ TERAPII PRZECIWNOWOTWOROWEJ
Authors: Samaszko-Fiertek Justyna , Khalatyan Alina , Dmochowska Barbara , Slusarz Rafał , Madaj Janusz
Published: January 2025

MOF materials (metal-organic frameworks) are a relatively organic-inorganic (hybrid) materials. Due to very good adsorption properties, large specific surfaces and large pore volumes, these compounds are quite intensively studied, and the number of organic- inorganic hybrids obtained is growing year by year. Most MOF compounds are crystalline two- or three-dimensional organometallic structures. They are an example of hybrid materials that are made of both inorganic and organic component. The inorganic part is represented by metal ions/clusters, while the organic skeleton contains neutral or charged organic linkers [1-3]. The most common metal cations included in organometallic lattices are: Zn2+, Cu2+, Cr3+, Al3+ and Mg 2+. Organic ligands can be neutral, positively or negatively charged, but they must be primarily electron pair donors, which means that they have nitrogen or oxygen-containing functional groups in their structure. Ligands’ role is to stitch these building units together to create extended framework structures, while metal ions provide structural integrity and durability. These materials have a well-developed specific surface and a large pore volume (570- 3800 m2/g). Thanks to the presence of coordination bonds in the structure, the skeletons of organometallic networks are flexible. Based on literature data, several methods of cancer treatment using MOFs are distinguished, e.g.: using passive targeting, active targeting, physicochemical targeting, and in a particular case using all three strategies (Fig. 2, Table 1) [12,13]. The ongoing work on the modification of the synthesized MOF structures based on zinc ions allows the preparing various types of cancer drugs based on their durability and high porosity. The ability to synthesize multifunctional Zn-MOFs is a new chapter in the design of chemotherapeutic agents. A particular example is ZIF-8. The combination of different strategies for the influence of the pH value of the environment or photochemical elements gives the opportunity to use the compounds in imaging and cancer diagnosis
WIELKA MOC W MAŁEJ CZĄSTECZCE - WŁAŚCIWOŚCI I ZASTOSOWANIA BISFOSFONIANÓW
Authors: Kozicka Dominika , Socha Karolina , Szarek Jarosław , Kuźnik Anna
Published: January 2025

Bisphosphonates (BPs) are a group of compounds that are extensively studied around the world. Bisphosphonates are organophosphorus compounds characterized by the presence of the P-C-P skeleton. They are synthetic, thermally stable, and hydrolysis-resistant pyrophosphate analogs that occur naturally in living organisms. BPs have the ability to chelate metals such as magnesium and calcium which results in their high affinity to bone tissue. [1] The above factors determine their biological properties and the wide range of related applications. Bisphosphonates have an established position on the pharmaceutical market and have been used in medicine for many years, mainly as anti-resorptive drugs. They are considered the gold standard in the prevention and treatment of many different bone diseases, such as osteoporosis or Paget disease. [1] The therapeutic potential of bisphosphonates, however, is not limited to the treatment of bone diseases, as more and more reports about their other useful biological properties appear in the literature. [2] The usefulness of bisphosphonates in imaging diagnostics and drug delivery systems is also being explored. [3-5] The following article provides a short literature review on BPs, mainly their structure, properties, and mechanism of action, as well as their current and potential applications.
WYKORZYSTANIE ENZYMÓW W DIAGNOSTYCE MEDYCZNEJ
Authors: Gruba Natalia
Published: January 2025

Each tissue has its own specific enzyme profile. Therefore, the detection of changes in the level of certain enzymes in disease states allows conclusions about the location and type of pathological changes occurring in the body. Only a few (out of several hundred) tissue enzymes are used in routine diagnostics - diagnostics of diseases of the liver, pancreas, skeletal muscles and heart muscle. In practice, this test consists in measuring the activity or determining the level of enzyme protein in body fluids. In this article, the characteristics of a few selected enzymes applicable in clinical practice will be presented.
NOWE MODYFIKOWANE MATERIAŁY ELEKTRODOWE DLA POTRZEB WOLTAMPEROMETRYCZNEGO OZNACZANIA TALU - METODOLOGIA BADAŃ WŁASNYCH
Authors: Karbowska Bożena , Modrzejewska-Sikorska Anna , Konował Emilia
Published: January 2025

Thallium is one of the most toxic heavy metals. Despite numerous studies conducted over many years, the main difficulty in the analysis of thallium is that it is present in deficient concentrations in various types of samples. Therefore, new electrode materials are being sought, characterised by high sensitivity, selectivity, and low detection limit, which could replace toxic mercury electrodes in standard voltammetric measurements.
The Development of Augmented Reality Based Student Worksheet on Human Respiratory System Course to Improve Critical Thinking Skills of Junior High School
Authors: Maimuna Siti , Wahyuni Sri , Ridlo Zainur Rasyid
Published: January 2025

Objective: The development of augmented reality based student is used to improve the critical thinking skills of junior high school science students. This research aims to describe the validity, practicality and effectiveness of augmented reality based student worksheet oh Human Respiratory System course. Method: This research applies the ADDIE model was carried out at Jember’ 12 Junior High School and the data collection instruments used are observation sheets, validation sheets, student response questionnaires, and test assessment sheets. Results: The results obtained are the validity of the product is declared valid with a percentage of 92%, the practicality results are classified as practicaland the effectiveness results are very positive. N-gain results of 0.55 which is included in the moderate category. Novelty: Augmented reality-based student worksheet can be used in science learning as an alternative learning media to improve critical thinking skills of junior high school students.
Optimizing Scientific Literacy: A Comprehensive Examination of the Effectiveness of Problem-Based Learning
Authors: Mulia Mala , Susantini Endang , Indana Sifak
Published: January 2025

Objective: Able to face global challenges. One approach that has garnered attention is problem-based learning, considered capable of enhancing students' scientific literacy. This article aims to design and analyze the improvement of scientific literacy through problem-based learning methods. Method: The method employed in this research is a literature review. Results: The analysis revealed that PBL significantly improves students' scientific literacy skills. N-Gain values indicated moderate to high gains, and t-test results showed significance values below 0.05, confirming a substantial increase in scientific literacy after PBL implementation. Novelty: This article provides a comprehensive evaluation of Problem-Based Learning (PBL) in enhancing scientific literacy. Analyzing 15 selected studies, it shows significant improvements in students' scientific literacy skills, supported by N-Gain values and t-test results. The review highlights PBL's effectiveness, including the integration of technology, and offers robust evidence of its positive impact on students' ability to understand and apply scientific information, thus enriching the literature on effective teaching strategies.
Bibliometric Analysis of the Ability to Solve Algebra Problems in Elementary School AKM Numeracy Context
Authors: Wijaya Budi , Mariana Neni , Rahaju Endah Budi
Published: January 2025

Objective: The purpose of this bibliometric analysis is to look at opportunities and trends in research related to the completion of algebra context numeration Assessment of Minimum Competence at the level of Elementary School using the VOS Viewer application. Method: The method used in this research is bibliometric, collecting data from articles or journals from 2021 to 2023 through the Google Scholar site using the Publish or Perish software of 500 articles or magazines. Results: Similar research results show that in 2021, there were 101 publications; in 2022, there were 166; and in 2023, there were 198. The number of quotes was 2097; the average quotation per year was 699; the quotations per paper was 4.51; the averages per writer were 1,222.65; the median number of papers/writers was 293.32; and the average number of writers/publishers was 2.09. Novelty: Variables related to the completion of algebra issues through the Minimum Competence Assessment at the elementary school level that have the opportunity and novelty to be studied in the future are in the context category of numeration consisting of personal, social, cultural, and scientific.
Tired But Can’t Stop: Exploring the Association of Fear of Missing Out (FoMo) and Social Media Fatigue among Emerging Adults
Authors: Ardelia Vania , Jaro'ah Siti , Maghfiroh Fitrania , Laksmiwati Hermien
Published: January 2025

Objective:  Indonesia ranks third as the country with the most social media users, with emerging adults making up the largest group. On average, Indonesians spend almost 6 hours a day playing social media. This condition can cause both physical and psychological problems. One of the impacts of excessive social media use is Social Media Fatigue (SMF). The level of SMF is influenced by several factors, one of which is Fear of Missing Out (FoMo), which is a fear of missing out on experiences that others are enjoying. SMF and FoMo can significantly impact an individual's mental health. The link between the two conditions is clear, but there is little in-depth research linking the two. This study aimed to explore the association of Fear of Missing out (FoMo) with Social Media Fatigue (SMF) among emerging adults. Method: A cross-sectional study design was conducted among 157 men and women emerging adults. Participants completed a self-administered questionnaire that consisted of demographic characteristics, Fear of Missing Out scale, and Social Media Fatigue scale. Data were analyzed using descriptive analysis and Pearson Correlation statistic technique.  Results: Descriptive analysis results showed that men showed a higher tendency of both fear of missing out and social media fatigue compared to women. Further, a significant yet moderate correlation was found between FoMo and SMF among emerging adults. Novelty: This study contributed to explore further on the relationship between fear of missing out (FoMo) and social media fatigue specifically among emerging adults.
The Practicality of Innovative Blended Learning Through The Meaning (IBLTM) Model Making to Improve Science Literacy
Authors: Amijaya Dody Tisna , Raharjo Raharjo , Ibrahim Muslimin , Hawari Asaduddin Al
Published: January 2025

Objective: Science literacy is essential for learners because it allows them to understand, analyze, and apply scientific concepts in everyday life and make decisions based on scientific information. This study aims to describe the practicality of the Innovative Blended Learning Model through Interpretation to improve students' science literacy. Method: The research method used was development research. Data collection used observation instruments. Data analysis was implemented using descriptive statistics for practicality tests. Results: The results of the trial showed that the level of practicality of the IBLTM learning model is high, which means that the IBLTM learning model is practical enough to be implemented in biology learning. Novelty: This research presents new findings related to the practicality of the IBLTM model by emphasizing how this model facilitates the process of deep meaning and active involvement of students in learning.
Design of virtual laboratory media based on HTML 5 Canvas and graphical user interface in physics learning
Authors: Zulkarnain Zulkarnain , Utami Linda Sekar , Sabaryati Johri , Islahudin Islahudin , Subhan Subhan , Arisandi Dea
Published: January 2025

Physics is an important part of the science curriculum at both the high school and college levels. Physics learning requires students to master abstract theoretical concepts, so it is not uncommon for these theoretical concepts to be difficult for learners to perceive. Abstract concepts in physics learning can be overcome through practical activities in concrete laboratories or virtual laboratories. This study aims to produce virtual laboratory media based on HTML 5 Canvas and Javascript programs packaged in Graphical User Interface (GUI) format in terms of experts, practicioners, and students. The research method used is research and development (R&D), using the 4D model (Define, Design, Develop, and Disseminate). The subjects were conducted in second-years physic students which consisted of 8 students (small group test) and in class XI high school students which consisted of 20 students (large group test). The instrument used were interview sheets, documentation, and questionnaires. The data were analyzed using descriptive analysis techniques. The results showed that virtual laboratory media was valid with a CVI score of 0,87 and reliable with a Percentage of Agreement score of 85,95% based on experts and practitioners judgment. In addition, based on the results of the practicality test for students, the test results were in the very practical category with a practicality score of 86,4% and 88,6% respectively for small group test and large group test. So it can be concluded that virtual laboratory media can be used to support physic learning.
Kontribusi Islam terhadap Perkembangan Pendidikan Islam dalam Era Industri 4.0
Authors: Rohman Taufikur , Ilyasin Mukhamad , Muadin Akhmad
Published: January 2025

Penelitian ini bertujuan untuk menganalisis kontribusi pendidikan Islam dalam menghadapi tantangan Revolusi Industri 4.0, dengan meninjau konsep pendidikan Islam, peran lembaga pendidikan Islam, objek garapan pendidikan, serta kompetensi guru Pendidikan Agama Islam (GPAI) dan siswa yang dibutuhkan di era modern. Penelitian ini dilakukan dengan metode literature review yang menganalisis berbagai literatur terkait perkembangan pendidikan Islam dalam konteks teknologi dan perubahan sosial. Hasil penelitian menunjukkan bahwa pendidikan Islam memiliki kemampuan adaptif yang signifikan melalui integrasi antara teknologi dan nilai-nilai agama. Lembaga pendidikan Islam, seperti madrasah dan pesantren, telah mulai mengadopsi teknologi dalam proses pengajaran, meskipun masih dihadapkan pada tantangan keterbatasan infrastruktur dan kebutuhan peningkatan kompetensi digital tenaga pendidik. Kompetensi siswa juga dikembangkan untuk memenuhi tuntutan era digital, dengan penekanan pada literasi digital, kemampuan berpikir kritis, dan keterampilan kolaboratif. Signifikansi penelitian ini terletak pada pentingnya memperkuat integrasi teknologi dalam pendidikan Islam tanpa mengabaikan nilai-nilai spiritual, yang dapat membentuk generasi berkarakter unggul dan berdaya saing di era modern.
Memberdayakan Anak Berkebutuhan Khusus: Peran Pendidikan Inklusif di SLB Tunas Harapan Mekongga Kolaka
Authors: Akbar Muhammad , Suhrah Suhrah , Angraeni Nia
Published: January 2025

Pendidikan inklusif adalah pendekatan yang memberikan kesempatan setara bagi anak-anak berkebutuhan khusus (ABK) untuk mendapatkan pendidikan berkualitas di lingkungan yang menghargai perbedaan. Penelitian ini bertujuan untuk mengungkap peran pendidikan inklusif di SLB Tunas Harapan Mekongga dalam memberdayakan anak berkebutuhan khusus (ABK), serta tantangan dan dampak penerapannya. Melalui metode wawancara, observasi, dan dokumentasi, penelitian ini menemukan beberapa hal penting. Pertama, strategi pemberdayaan ABK meliputi pendekatan individualisasi pembelajaran, pengembangan keterampilan hidup, dan penggunaan alat bantu serta teknologi pendukung. Kedua, tantangan yang dihadapi mencakup keterbatasan fasilitas dan sumber daya, kurangnya guru yang terlatih dalam pendidikan khusus, serta kendala transportasi bagi siswa. Ketiga, dukungan orang tua sangat signifikan dalam mendukung proses pembelajaran, meskipun dukungan dari komunitas masih terbatas. Keempat, dampak pendidikan inklusif yang tercatat meliputi peningkatan kepercayaan diri, kemampuan sosial, serta kemajuan akademik yang sesuai dengan kemampuan setiap siswa. Penelitian ini menyimpulkan bahwa meskipun pendidikan inklusif di SLB Tunas Harapan Mekongga memberikan manfaat besar bagi ABK, namun sejumlah tantangan yang ada memerlukan perhatian lebih dari berbagai pihak, termasuk pemerintah dan masyarakat, untuk mendukung keberlanjutan dan pengembangan pendidikan inklusif.
Moralitas Digital dalam Pendidikan: Mengintegrasikan Nilai-Nilai Al-Qur'an di Era Teknologi
Authors: Iwani Fatimah Nurlala , Abubakar Achmad , Ilyas Hamka
Published: January 2025

Tujuan dari penelitian ini adalah memberi penjelasan secara mendalam hubungan antara moralitas digital dengan nilai-nilai Al-Qur’an dalam konteks penggunaan teknologi di bidang pendidikan. Dengan mempertimbangkan tantangan moral yang dihadapi oleh umat islam di era digital, kita akan mengeksplorasi bagaimana nilai-nilai yang terkandung al-Qur’an memberikan pedoman etika serta prinsip-prinsip moral yang mampu membantu generasi penerus menghadapi tantangan tersebut. Metode penelitian yang digunakan adalah metode kualitatif deskriptif. Teknik dalam pengumpulan data yang digunakan ialah dengan pendekatan studi pustaka/library research, yaitu pengumpulan data dengan cara memahami dan mempelajari teori-teori dari berbagai literatur yang berhubungan dengan penelitian ini.  Adapun hasil dari penelitian ini adalah al-Qur’an mengajarkan prinsip-prinsip moral yang dapat diterapkan dalam berbagai aspek kehidupan, termasuk penggunaan teknologi. Nilai-nilai al-Qur’an tetap relevan dan dapat digunakan dalam menghadapi tantangan yang ada di kehidupan modern, meskipun wahyu al-Qur’an diturunkan jauh sebelum munculnya era teknologi dan media sosial ini. Dengan memahami dan mengaplikasikan nilai-nilai al-Qur’an peserta didik dapat mengembangkan karakter yang kokoh dan beretika.
Analisis Pengembangan Kurikulum pada Pendidikan Agama Islam
Authors: Khasanah Safiratul , Yahya Maula Devina , Rindihastuti Arifa , Fauziyah Agustina Nur , Arzaqi Muhammad Yusril , Zaman Badrus
Published: January 2025

Penelitian ini dilatarbelakangi oleh urgensi pengembangan kurikulum Pendidikan Agama Islam (PAI) dalam merespons permasalahan moral dan sikap remaja di era modern yang terpapar oleh arus budaya global. Tujuan utama penelitian adalah mengeksplorasi bagaimana integrasi antara pendidikan umum dan pendidikan agama diterapkan untuk membentuk siswa yang unggul baik secara intelektual maupun spiritual. Penelitian ini menggunakan metode kualitatif dengan pendekatan deskriptif. Data dikumpulkan melalui wawancara mendalam, observasi model non partisipan, serta dokumentasi, sementara keabsahan data diuji melalui teknik triangulasi sumber untuk memastikan validitas dan reliabilitasnya. Hasil penelitian menunjukkan bahwa SMA IT Abu Bakar telah berhasil mengembangkan kurikulum yang bersifat holistik. Kurikulum tersebut menggabungkan pembelajaran berbasis kasus (case-based learning) dengan model praktik langsung yang memanfaatkan media dan teknologi modern, serta lingkungan sekitar. Para guru juga menerapkan inovasi dan teknik pengajaran yang memperhatikan kebutuhan siswa secara individual, sehingga pembelajaran tidak hanya fokus pada pencapaian akademik, tetapi juga pada penguatan karakter dan internalisasi nilai-nilai keislaman.
Linguistic whateverism – a study on an (in)consistency in linguistic behavior based on the usage of Anglicisms
Authors: Delić Haris , Džanković Asmir , Burcu Kapukaya Mihrimah , Alakbarov Elnur
Published: January 2025

This study investigates the phenomenon of linguistic whateverism among Bosnian high school students, focusing on the usage of English loanwords in everyday speech. A survey was conducted to assess the prevalence, frequency, and contextual factors influencing the integration of Anglicisms into Bosnian language use. The findings reveal that 71.5% of participants incorporate English words into their conversations, primarily in informal settings and often when communicating with peers who possess similar English proficiency. While many students display a relaxed attitude toward language mixing, with 72.6% expressing indifference towards the use of English in Bosnian, a significant portion (67.0%) expresses concern over the potential erosion of the Bosnian language. The analysis indicates that the influence of English is particularly strong in contexts related to technology and social media, suggesting a shift towards linguistic pragmatism among youth. Despite the high acceptance of Anglicisms, there remains a notable desire to preserve the integrity of the Bosnian language. These findings underscore the complexity of language evolution in a globalized context and highlight the need for ongoing dialogue about linguistic identity and cultural preservation among young speakers.
ВПЛИВ СУЧАСНИХ ТЕХНОЛОГІЙ УПРАВЛІННЯ ПЕРСОНАЛОМ НА ЕФЕКТИВНІСТЬ ПУБЛІЧНОГО УПРАВЛІННЯ
Authors: ТУЛЬЧИНСЬКИЙ Ростислав Володимирович , ЧЄРЄНКОВ Вячеслав Валентинович
Published: January 2025

Сучасні технології управління персоналом суттєво змінюють підходи до організації публічного управління, сприяючи підвищенню ефективності діяльності державних органів. У статті досліджується вплив інноваційних рішень у сфері HR-технологій на основі автоматизації процесів, використання великих даних та штучного інтелекту.
Основну увагу приділено аналізу впровадження цифрових платформ для управління персоналом у публічному секторі, а також їхньому впливу на якість прийняття рішень, мотивацію працівників та оптимізацію організаційних процесів.
Розглянуто конкретні приклади використання HR-технологій, таких як системи управління продуктивністю, автоматизовані платформи підбору персоналу та інструменти для навчання і розвитку кадрів. Методологія дослідження передбачала застосування аналізу вторинних даних, кейс-стадій і порівняльного аналізу. Результати демонструють позитивний вплив впровадження сучасних технологій на продуктивність працівників, скорочення адміністративних витрат і підвищення прозорості процесів управління.
Практична значущість отриманих результатів полягає в можливості адаптації технологій управління персоналом для різних сфер публічного управління, що забезпечує ефективне використання людського потенціалу. У висновках окреслено перспективи подальшого розвитку цифрових HR-технологій у державному секторі, включаючи їх інтеграцію з електронним урядуванням.
ОСОБЛИВОСТІ ТА ПРОБЛЕМИ ВИКОРИСТАННЯ ЛЮДСЬКОГО КАПІТАЛУ В УМОВАХ ВОЄННОГО ЧАСУ
Authors: ТОЧИЛІНА Юлія Юріївна
Published: January 2025

У статті обґрунтовано необхідність дослідження особливостей використання людського капіталу в сучасних умовах. Акцентовано увагу на тому, що в результаті цифровізаційно-інноваційних змін людський капітал набуває нових якісних характеристик, які дозволяють визначити його як один з основних ресурсів, що здатний забезпечити ефективне функціонування національної економіки. Доцільність проведення наукового пошуку в даному напрямі збільшує свою актуальність в умовах розгортання повномасштабної війни, адже такий аналіз спроможний запропонувати шляхи збереження, адаптації та подальшого розвитку людського капіталу як цінного ресурсу вітчизняної економіки. Запропоновано під використанням людського капіталу розуміти процес, що передбачає реалізацію в різних видах діяльності вже сформованих складових людського капіталу, результатом чого на індивідуальному рівні є збільшення продуктивності праці, заробітної плати та благополуччя самої людини, а на загальнонаціональному – економічне піднесення країни та суспільного добробуту. Під час вивчення факторів, що впливають на ефективність використання людського капіталу виділено чотири групи: економічні, соціально-демографічні, техніко-інноваційні, науково-освітні. З’ясовано, що ефективне використання людського капіталу дозволить створити підґрунтя для повоєнного відновлення національної економіки та передумови для досягнення сталих темпів економічного зростання. Проте, практичне вирішення окреслених завдань зіштовхується зі значними проблемами, серед яких виокремлено економічні, соціальні, інфраструктурні, психологічні, безпекові тощо.
СТРАТЕГІЧНЕ УПРАВЛІННЯ ДІДЖИТАЛІЗАЦІЄЮ ПІДПРИЄМСТВА У КОНТЕКСТІ ІННОВАЦІЙНОГО МЕНЕДЖМЕНТУ
Authors: УРБАНСЬКИЙ Максим Вікторович
Published: January 2025

У статті досліджено концептуальні та практичні аспекти стратегічного управління діджиталізацією підприємства у контексті інноваційного менеджменту, що є особливо актуальним у сучасних умовах стрімкого розвитку технологій.
Діджиталізація виступає потужним інструментом для підвищення конкурентоспроможності підприємств, оптимізації бізнес-процесів та створення нових можливостей для розвитку, водночас створюючи нові виклики для управлінців.
У статті розглянуто, як впровадження цифрових технологій, зокрема штучного інтелекту, Інтернету речей (IoT), блокчейн-технологія, великих даних і хмарних рішень впливає на управління інноваціями та забезпечує підприємству гнучкість і адаптивність до змінних ринкових умов. На основі аналізу вітчизняного та зарубіжного досвіду впровадження цифрових стратегій у статті сформульовано рекомендації для побудови адаптивної системи управління, яка забезпечує довгострокову стійкість підприємства та його конкурентоспроможність.
Впровадження стратегічного підходу до діджиталізації дозволяє підприємствам створювати умови для інноваційного розвитку, підвищувати ефективність операційної діяльності та знижувати ризики, пов’язані зі змінами у зовнішньому середовищі. Отримані результати можуть бути корисними для керівників та фахівців, які займаються розробкою та реалізацією цифрових стратегій, спрямованих на довгострокове забезпечення конкурентних переваг підприємства. Автор наголошує, що майбутні дослідження в цьому напрямі мають включати детальний аналіз інструментів для оцінки ефективності діджиталізації та управління ризиками, що сприятиме подальшому вдосконаленню стратегічного управління в умовах цифрової трансформації.
ВИКОРИСТАННЯ ТЕХНІК КРЕАТИВНОСТІДЛЯ РОЗРОБКИ ІННОВАЦІЙ
Authors: СТАСОВСЬКИЙ Юрій Володимирович
Published: January 2025

У статті проаналізовано сучасні методи стимулювання творчого мислення та визначено їх роль в інноваційних процесах. На основі ретельного огляду наукової літератури, що охоплює період з 2010 по 2023 роки, було ідентифіковано 166 технік креативності. Основною метою роботи є систематизація знань про методики активізації творчого мислення, визначення їхніх сильних і слабких сторін, а також розробка класифікації, яка дозволяє орієнтуватися в широкому спектрі доступних інструментів. У межах дослідження проведено аналіз таких технік як Brainstorming, Mind-mapping, TRIZ, Six Thinking Hats, Morphological Analysis, Synectics, Role-playing, SCAMPER та інших. Запропонована класифікація передбачає поділ технік за складністю та функціональним призначенням, що дозволяє розглядати їх як інструменти для організації творчого процесу, активізації мислення або алгоритмічного вирішення завдань. Результати підтверджують значущість технік креативного мислення в сучасному світі, де інновації відіграють ключову роль у досягненні успіху. Використання цих методів сприяє ефективному пошуку нових ідей, розробці інноваційних продуктів і послуг, а також забезпечує гнучкість організацій у пристосуванні до змін ринкових умов. Запропонована класифікація та висновки дослідження створюють підґрунтя для подальших наукових розвідок і практичного впровадження у сфері управління інноваціями.
ДОСЛІДЖЕННЯ ПІДХОДУ ЩОДО ЗАБЕЗПЕЧЕННЯ НАЦІОНАЛЬНОЇ БЕЗПЕКИ
Authors: ГАРАФОНОВА Ольга Іванівна , ПОПОВИЧ Ростислав Ігорович
Published: January 2025

У статті розглянуто актуальні підходи до забезпечення національної безпеки, що є ключовим пріоритетом для стабільного розвитку та захисту суверенітету держави. З огляду на посилення глобальних загроз, зокрема кібернетичних атак, терористичних актів, економічного тиску та інформаційних маніпуляцій, сучасні підходи до національної безпеки потребують комплексного та адаптивного підходу. Дослідження фокусується на інтеграції політичних, економічних, соціальних, військових і інформаційних інструментів, що сприяють забезпеченню стабільності держави та ефективному управлінню її безпековими ресурсами. Метою дослідження є аналіз існуючих підходів і стратегій у сфері національної безпеки, а також обґрунтування необхідності використання комплексного підходу, який відповідає сучасним викликам. У статті розглянуто роль технологічних інновацій, таких як штучний інтелект, великі дані, блокчейн, а також реформування сектору безпеки та міжнародного співробітництва. Застосування цих підходів дозволяє забезпечити гнучкість і адаптивність національної безпекової системи, підвищуючи її здатність протистояти новим викликам. Основні результати дослідження підкреслюють важливість інтегрованих підходів, які сприяють злагодженій роботі всіх компонентів національної безпеки. Викладені в статті висновки та рекомендації можуть бути корисними для розробки ефективних стратегій безпеки, що відповідають специфіці українського контексту. Робота також акцентує увагу на важливості подальших досліджень у сфері управління ризиками та вдосконалення методів оцінки безпекових загроз.
Research and Simulation of the A* Algorithm in Matlab
Authors: Chen Yifei
Published: January 2025

With the rapid advancement of artificial intelligence and networking, path planning has found widespread applications across various domains, including artificial intelligence, mechanical control, robotics, and the automotive industry. The A* algorithm is a very common path-planning algorithm. Traditional research mainly focuses on the application of the A* algorithm and its combination with other algorithms, while neglecting the study of the A* algorithm itself, such as its heuristic function. This article will conduct an in-depth study of the A* algorithm using MATLAB, introduce the weighted A* and dynamic A* algorithm, and study the parameter influence and improvement of the A* algorithm. Research has shown that when the weight is greater than 1, it will reduce the optimality of the results; Smaller weights usually lead to better exploration, but the search process may slow down. The dynamic A* algorithm has many characteristics such as dynamic updates and reverse search. Therefore, this study is of great significance for improving the efficiency of path planning.
A Study of Heuristic-based Path Planning in Complex Maze Using the A* Algorithm with Cost Optimization and Visualization
Authors: Cui Bohan
Published: January 2025

Route planning is crucial in areas such as robotics, autonomous driving, and drone navigation. Especially in earthquake and other disaster scenarios, route planning in emergency rescue is more difficult. In this paper, A route planning method combining the A star algorithm and multi-cost optimization is proposed to consider road deterioration, risk areas, and different crossing costs in the complex post-earthquake environment. By simulating a 20×20 post-disaster maze, the crossing costs are randomly assigned. Algorithm A is used to determine the cheapest path from the starting point to the destination point. The results show that the optimized A* algorithm has excellent performance in terms of path length, search efficiency, and computational overload, especially in a complex disaster environment. Dynamic visualization technology shows the process of finding nodes and the final path, which helps to improve the decision-making efficiency of emergency response and provides strong technical support for disaster relief.
Relationship between Pre-Hospital Delays and Patient Outcomes in Acute Stroke Management: A Systematic Review
Authors: Hakeem Ahmad Abdulelah , Mahabbat Ahmed anam ahmed , Abdullah Kamel Alhashmi Alamer  , Reem Mamdouh Alaseeri  , Osama Ahmed Alnadwi  , Safwan abdulrahman s alsaedi  , Hattan Safar S Alotaibi  , Mohjah Othman Ahmed Sindi  , Muath Saeed Ali ALAMRI  , Anhar Abdulhamid M Turkustani
Published: January 2025

This study aimed to investigate the associations between pre-hospital delays and outcomes for patients in acute stroke management. A total of 554 pertinent publications were found after a comprehensive search across four databases. Full-text publications (288) were examined after duplicates were eliminated using Rayyan QCRI and relevance was checked; six studies finally satisfied the requirements for inclusion. A total of 8906 patients were included, more than half of them 4953 (55.6%) were males. Research showed that early hospital admission leads to better survival, less disability, and better function, mainly from the early delivery of treatment such as thrombolysis. Nevertheless, delays are common for a variety of reasons including symptom appreciation, systemic, and/or logistical bottlenecks in emergency services. Reducing these delays by improved public awareness, improved emergency response, and better communication both between hospitals and emergency medical services (EMSs) will significantly enhance the stroke outcome and the disability burden itself. Minimizing pre-hospital delays is crucial for improving outcomes in acute stroke management. Timely and uninterrupted treatment increases access to life-saving interventions, reducing mortality and post-stroke disability. Pre-hospital delay has demonstrable effects on the outcome of acute stroke management, as early intervention is essential for survival and recovery. Strategies such as public awareness campaigns, enhanced EMS systems, and systemic reforms are essential for mitigating delays and improving stroke care efficiency. Future research should focus on evaluating interventions to reduce these delays, addressing healthcare disparities, and considering regional variations to optimize outcomes and reduce the global burden of stroke.
Microvascular Complication: "Microalbuminuria"—Are Camel Dairy Products Really Helpful?
Authors: Alturki Sultan T. , Alanoud S. Alwesaimer  , Naif M. Alshalhoub  , Abdulelah S. Alsughayyir
Published: January 2025

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Peran Organisasi Mahasiswa dalam Meningkatkan Kesadaran Kewarganegaraan di Kalangan Mahasiswa PGSD UNIMED
Authors: Nasution Hajjaziah , Utari Septi , Siregar Hanif Luthfi , Aprilia Nada , Lubis Putri Ramadhani , Sari Nopyta , Fadilah Rizki , Purba Dearni Asri Br
Published: January 2025

This research analyzes the role of student organizations in increasing citizenship awareness among students of the Elementary School Teacher Education Study Program, Medan State University. The research method used was qualitative with a descriptive design, involving structured interviews, observation, and documentation. The research subjects consisted of 30 people, namely 20 young members of student organizations and 10 active members. The results showed that student organizations play a significant role in increasing citizenship awareness through educational activities such as seminars and social actions. As many as 85% of respondents claimed that participation in organizational activities helped them understand the values of democracy and diversity. Although most respondents felt the benefits of their involvement, there are still challenges in terms of interest and active participation among students who are not involved. This research emphasizes the importance of educational institutions' support to facilitate activities that can increase civic awareness among students
Keperluan Media Poster pada Materi Adab Jual Beli Online di Kelas X MA Darul Ulum
Authors: Aspiani Ahmad , Kastalani Akhmad
Published: January 2025

This study aims to develop poster media on the material of adab buying and selling online in class X MA Darul Ulum. The research method used is Research and Development (R&D) with data collection techniques through observation, questionnaires / surveys, interviews, and documentation. The research subjects were class X students totaling 27 people. The results showed that the use of poster media in learning fiqh buying and selling material at MA Darul Ulum Palangka Raya was in the very effective category. This can be seen from two indicators, namely: (1) The effectiveness of poster learning media obtained a percentage of 72%, and (2) The effectiveness of buying and selling material obtained a percentage of 72%. Thus, it can be concluded that the use of poster media in learning fiqh buying and selling material at MA Darul Ulum Palangka Raya is very effective
Bermain Ice Breaking dalam Bahasa Arab untuk Anak Usia Dini
Authors: Lubis Hilda Zahra , Sejati Indah Sri , Fadillah Ranti , Safira Lailan , Aminah Siti
Published: January 2025

Arabic vocabulary mastery (mufrodat) is one of the main keys to mastering Arabic. However, a monotonous learning environment often becomes an obstacle for students to achieve this mastery. This study aims to analyze the effectiveness of icebreaker strategies in increasing student engagement in learning Arabic mufrodat. This study uses a descriptive qualitative approach with data collection methods through observation, interviews, and documentation. The results of the study showed that icebreaker strategies were able to change the classroom atmosphere from initially boring to more active, fun, and conducive. This strategy succeeded in attracting students' attention and increasing their participation in the learning process. In conclusion, icebreakers are an effective tool for creating an entertaining learning environment while supporting the improvement of Arabic vocabulary mastery. This strategy can be adapted as an innovative learning method to create a more interactive and motivating atmosphere for students
Design Research of Mathematical Problem Solving Ability in Era 4.0: Pengaruh Model Pembelajaran SOLE and Self-Regulated Learning
Authors: Risqa JL Ana , Rahmita Nela , Alhaq Arini , Dewi Novian Riskiana
Published: January 2025

The ability to solve mathematical problems can be interpreted as a potential possessed by students so that they can solve mathematical problems in solving mathematical problems. This quantitative research explains the mathematical problem-solving ability of students by implementing the SOLE (Self Organized Learning Environments) learning model and self-regulated learning of students as a controller. This study aims to determine the effect of the SOLE learning model on students' mathematical problem solving abilities by controlling self-regulated learning and the effect of self-regulated learning covariate variables on students' mathematical problem solving abilities, as well as the simultaneous effect of the SOLE learning model and self-regulated learning on students' mathematical problem solving abilities. Participants in this study totaled 61 students in junior high school, with details of 30 students studying using the SOLE model and 31 students studying with the conventional model. The tools used to collect data are questionnaires and essay tests. The hypothesis test uses the one-way ancova test, the result of the hypothesis test is that there is an influence of the SOLE learning model on students' mathematical problem-solving ability by controlling self-regulated learning and there is an influence of self-regulated learning covariate variables on students' mathematical problem-solving ability, and there is a simultaneous influence of the SOLE learning model and self-regulated learning on mathematical problem-solving ability.
Peranan Ilmu, Pengetahuan, Teknologi, dan Seni (IPTEKS) dalam Meningkatkan Kualitas Kehidupan Umat Islam
Authors: Priyadani M. Trianugrah , Morales Muhhamad Eric , Darojatin Marssela Zakiyah , Sabila Fransisca Rachma , Fitriyah Itsnasari Qublik
Published: January 2025

This article explores the relationship between science, technology, and art in an Islamic view, emphasizing religious attitudes and perspectives on the advancement of human thought and creativity. This study uses a literature study method. Information is obtained from literature reviews that include various sources such as academic journals, online articles, and relevant case studies. The analysis was carried out thoroughly on the data that had been collected, with an emphasis on the relevance of the information to the main theme of the writing. The results obtained from this study are that the application of science, technology, and art in daily life in accordance with Islamic teachings can create a balance between spiritual and material aspects, bring happiness in this world and the hereafter, and make a significant contribution to building a better human civilization.
Assess Nursing Student Perception Regarding Teamwork in Private Nursing College Karachi
Authors: Khan Abbas , Bibi Afsha , Ali Rizwan , Bacha Adil , Khan Hazrat Bilal , Hanif Muhammad Usama , Khan Waqar , Khan Bilal , Sabghatullah Hafiz , Khan Yasir Syed
Published: January 2025

Through strategies like team-based learning and interprofessional education, the importance of teamwork in nursing education is highlighted. Objective: To assess nursing student perception regarding teamwork in a private nursing college in Karachi. Methods: A validated questionnaire was used in this cross-sectional study at Horizon School of Nursing in Pakistan, among 175 Bachelor of Science in Nursing students. Data were gathered over the course of four months, and demographic correlations were examined using SPSS version 26.0. The study placed a high priority on ethical considerations.Results: The attitudes and perspectives of nursing students on teamwork in healthcare settings are examined in this study. Although 80% of participants acknowledge shared duties, a considerable number (76%) exhibit aversion towards working in teams. Issues including unequal workload distribution (52.6%) and perceived low importance on personal opinions (57.1%) are common among those surveyed. Furthermore, most of the respondents saw team meetings as time-consuming (76%), ineffective (57.1%), and leading to a decrease in workload (68%). Still, the majority (73.7%) acknowledge that teamwork improves talent as well. Conclusion: The study on nursing students' perspectives of cooperation reveals a complicated environment characterized by problems such as incomplete assignments, shared responsibility, and non-participation.