bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterization of the Protective Immune Responses Conferred by Recombinant BCG Overexpressing Components of Mycobacterium tuberculosis Sec Protein Export System
Authors: Nisa Annuurun , Counoupas Claudio , Pinto Rachel , Britton Warwick J. , Triccas James A.
Published: June 2022

Mycobacterium bovis Bacillus Calmette-Guérin (BCG) is the only approved vaccine against tuberculosis (TB). However, its efficacy in preventing pulmonary TB in adults is limited. Despite its variable efficacy, BCG offers a number of unique and beneficial characteristics, which make it suitable as a vaccine vehicle to express recombinant molecules. In Mycobacterium tuberculosis, the general Sec pathway is an essential cellular process, and it is responsible for exporting the majority of proteins across the cytoplasmic membrane, including potent immune-protective antigens, such as members of the antigen 85 (Ag85) complex. We engineered BCG to overexpress the M. tuberculosis SecDFG proteins in order to improve the efficiency of the Sec-dependent export system and, thus, enhance the secretion of immunogenic proteins. BCGSecDFG displayed increased intracellular survival within macrophages in vitro and greater persistence in the lymphoid organs of vaccinated mice than parental BCG. In addition, vaccination with BCGSecDFG generated higher numbers of IFN-γ-secreting T cells in response to secreted mycobacterial antigens compared to BCG, particularly members of the Ag85 complex. Furthermore, vaccination with BCGSecDFG significantly reduced the bacterial load in the lungs and spleens of M. tuberculosis-infected mice, which was comparable to the protection afforded by parental BCG. Therefore, the modification of protein secretion in BCG can improve antigen-specific immunogenicity.
COVID-19 Vaccination Hesitancy among Healthcare Workers—A Review
Authors: Peterson Christopher J. , Lee Benjamin , Nugent Kenneth
Published: June 2022

The COVID-19 pandemic and its associated vaccine have highlighted vaccine hesitancy among healthcare workers (HCWs). Vaccine hesitancy among this group existed prior to the pandemic and particularly centered around influenza vaccination. Being a physician, having more advanced education, and previous vaccination habits are frequently associated with vaccine acceptance. The relationship between age and caring for patients on COVID-19 vaccination is unclear, with studies providing opposing results. Reasons for hesitancy include concerns about safety and efficacy, mistrust of government and institutions, waiting for more data, and feeling that personal rights are being infringed upon. Many of these reasons reflect previous attitudes about influenza vaccination as well as political beliefs and views of personal autonomy. Finally, several interventions to encourage vaccination have been studied, including education programs and non-monetary incentives with the most effective studies using a combination of methods.
Single Nucleotide Polymorphisms, Gene Expression and Economic Evaluation of Parameters Associated with Mastitis Susceptibility in European Cattle Breeds
Authors: Ateya Ahmed I. , Ibrahim Samer S. , Al-Sharif Mona M.
Published: June 2022

The objective of this study was to explore single nucleotide polymorphisms (SNPs), gene expression and economic evaluation of parameters associated with mastitis susceptibility in Holstein and Brown Swiss dairy cows. Two hundred and forty Holstein and Brown Swiss dairy cows (120 cows of each breed) were used in this study. The investigated dairy cows in each breed were allocated into two equal-sized groups (60 cows each); mastitis tolerant and affected groups. PCR-DNA sequencing of SELL, ABCG2, SLC11A1, FEZL, SOD1, CAT, GPX1, and AhpC/TSA revealed nucleotide sequence variations in the form of SNPs associated with mastitis tolerance/susceptibility in investigated Holstein and Brown Swiss dairy cows. Levels of SELL, SLC11A1 and FEZL gene expression were significantly up-regulated in mastitic Holstein and Brown Swiss dairy cows than in tolerant ones. Meanwhile, ABCG2, SOD1, CAT, GPX1, and AhpC/TSA genes were significantly downregulated. Regarding the economic parameters, significant differences were recorded for net returns and a reduction in the percentage of net profit, as the higher values of net returns were recorded for tolerant dairy cows than mastitic ones in both breeds; moreover, the net profit was reduced by 39% and 27% in mastitic Holstein and Brown Swiss dairy cows, respectively, when compared to tolerant ones. The results herein confirmed the potential significance of investigated genes as candidates for mastitis tolerance/susceptibility in Holstein and Brown Swiss dairy cows. Mastitis also has detrimental impacts on economic efficiency in dairy farms.
Perspectives on the Combined Use of Electric Brain Stimulation and Perceptual Learning in Vision
Authors: Maniglia Marcello
Published: June 2022

A growing body of literature offers exciting perspectives on the use of brain stimulation to boost training-related perceptual improvements in humans. Recent studies suggest that combining visual perceptual learning (VPL) training with concomitant transcranial electric stimulation (tES) leads to learning rate and generalization effects larger than each technique used individually. Both VPL and tES have been used to induce neural plasticity in brain regions involved in visual perception, leading to long-lasting visual function improvements. Despite being more than a century old, only recently have these techniques been combined in the same paradigm to further improve visual performance in humans. Nonetheless, promising evidence in healthy participants and in clinical population suggests that the best could still be yet to come for the combined use of VPL and tES. In the first part of this perspective piece, we briefly discuss the history, the characteristics, the results and the possible mechanisms behind each technique and their combined effect. In the second part, we discuss relevant aspects concerning the use of these techniques and propose a perspective concerning the combined use of electric brain stimulation and perceptual learning in the visual system, closing with some open questions on the topic.
Urban Runoff Control and Sponge City Construction
Authors: Jia Haifeng , Hu Jiangyong , Huang Tianyin , Chen Albert S. , Ma Yukun
Published: June 2022

Rapid population growth, urbanization and high-intensity human activities cause a multitude of extremely serious environmental problems all over the world [...]
Seasonal Variation and Vertical Distribution of Inorganic Nutrients in a Small Artificial Lake, Lake Bulan, in Mongolia
Authors: Baterdene Ariunsanaa , Nagao Seiya , Zorigt Baasanjav , Ochir Altansukh , Fukushi Keisuke , Davaasuren Davaadorj , Gankhurel Baasansuren , Munkhsuld Enkhuur , Tsetsgee Solongo , Yunden Ariuntungalag
Published: June 2022

This is the first seasonal observation study on nutrient dynamics undertaken in a small freshwater lake with eutrophication in Mongolia. The vertical profile and seasonal fluctuation of nutrients are crucial to understanding the biogeochemical cycles in aquatic systems. In this study, field research was carried out at a small and shallow lake, Lake Bulan, in the lower Kharaa River basin. The area has been receiving increased nutrient loads from the water catchment area for the last 20 years. Water samples were collected seasonally from the lake from 2019–2022 and analyzed for nutrients, major cations, trace metals, and dissolved organic carbon. The average concentration of dissolved inorganic nitrogen (DIN) in the surface lake water had a wide seasonal variation from 0.26 ± 0.11 mg N/L in August to 1.44 ± 0.08 mg N/L in January. Seasonal differences were also observed in the vertical profiles. Concentrations were relatively similar at the various water depths in April and September at turnover time. Thermal stratification was observed when the lake was covered in ice, with the maximum concentrations being observed in the bottom layer in the months of January and August. The phosphate concentration showed a similar variation trend. These results indicate that both the summer and winter stratifications are important for regeneration of nutrients in the bottom layer, biochemical cycling, and mitigating impacts of global warming on small and shallow lakes in Mongolia.
Capability and Robustness of Novel Hybridized Artificial Intelligence Technique for Sediment Yield Modeling in Godavari River, India
Authors: Yadav Arvind , Joshi Devendra , Kumar Vinod , Mohapatra Hitesh , Iwendi Celestine , Gadekallu Thippa Reddy
Published: June 2022

Suspended sediment yield (SSY) prediction plays a crucial role in the planning of water resource management and design. Accurate sediment prediction using conventional models is very difficult due to many complex processes. We developed a fully automatic highly generalized accurate and robust artificial intelligence models for SSY prediction in Godavari River Basin, India. The genetic algorithm (GA), hybridized with an artificial neural network (ANN) (GA-ANN), is a suitable artificial intelligence model for SSY prediction. The GA is used to concurrently optimize all ANN’s parameters. The GA-ANN was developed using daily water discharge, with water level as the input data to estimate the daily SSY at Polavaram, which is the farthest gauging station in the downstream of the Godavari River Basin. The performances of the GA-ANN model were evaluated by comparing with ANN, sediment rating curve (SRC) and multiple linear regression (MLR) models. It is observed that the GA-ANN contains the highest correlation coefficient (0.927) and lowest root mean square error (0.053) along with lowest biased (0.020) values among all the comparative models. The GA-ANN model is the most suitable substitute over traditional models for SSY prediction. The hybrid GA-ANN can be recommended for estimating the SSY due to comparatively superior performance and simplicity of applications.
Young People’s Perspectives on Online Hate, Unwanted Sexual Content, and ‘Unrealistic’ Body- and Appearance-Related Content: Implications for Resilience and Digital Citizenship
Authors: Setty Emily
Published: June 2022

Young people encounter and experience both risks and opportunities when participating as actors and interactors in online spaces. Digital skills and resilience are considered important parts of a “rights-based” approach to keeping young people “safe” online in ways that enable them to avoid harm while benefiting from the opportunities. The present paper discusses findings from focus group research conducted in England with 60 young people aged 13 to 21. The research explored their perspectives on responding to different online harms, including online hate, unwanted sexual content, and unrealistic body- and appearance-related content. The findings are discussed in terms of scholarship on digital citizenship, specifically regarding the social, affective, and technical dimensions of online life and the skills required for resilience. The analysis suggests that there was a tension between young people’s individualistic responsibilisation of themselves and one another for responding to risk online and the socio-emotional aspects of online life as perceived and recounted by them in the focus groups. It is concluded that a youth-centred approach to resilience is required that encapsulates the multidimensional nature of encountering, experiencing, and responding to risk online.
Improving the quality of confectionery products with the use of structure formers and preservatives
Authors: Kazantsev E.V. , Kondratiev N.B.
Published: June 2022

The paper shows the aspects of improving the quality of pastilles and marmalade containing fruit components. The article has proposed a methodology that includes methods for assessing the properties of pectin, gelatin, and agar jelly, using the ST-2 structurometer, and a method for determining the density of the marshmallow mass, which makes it possible to justify the choice of structure formers and foam formers. The relationship of the content of the preservative sulfur dioxide in raw materials, semi-finished products and various types of confectionery products has been studied. It has been established that the content of sulfur dioxide for pastilles, marshmallows and fruit marmalade exceeds 10 mg/kg, since they contain sulfited fruit components. Chewing marmalade and plain chocolate contain only 5 and 7 mg/kg, respectively.
Practical aspects of establishing and justifying the shelf life of flour confectionery
Authors:   Laboratory for Flour Confectionery Production, branch of the V.M. Gorbatov Federal Research Center for Food Systems of the RAS, Misteneva S.Yu.
Published: June 2022

Currently, an important problem of the confectionery industry is the discrepancy between the declared shelf life of confectionery products and the actual period of preservation of their quality indicators. The article shows the need for comprehensive research to justify the established shelf life of confectionery products; the procedure for conducting a sanitary and epidemiological assessment of the justification of their shelf life and storage conditions is considered.
Forecasting the safety of confectionery products by microbiological indicators
Authors:   All-Russian Research Institute of the Confectionery Industry — Branch of the V.M. Gorbatov Federal Research Center for Food Systems of the RAS, Rudenko O.S. , Bazhenova А.Е. ,   All-Russian Research Institute of the Confectionery Industry — Branch of the V.M. Gorbatov Federal Research Center for Food Systems of the RAS
Published: June 2022

The moisture content in confectionery products influences the processes of microbiological changes. A high mass fraction of moisture (more than 20%) in cakes predetermines the presence of a favorable environment for the development of all types of microorganisms. Studies of potential sources of microbiological contamination of products and identification of the microorganism type make it possible to identify the source of its origin. So, in the test sample of the cake, the presence of a yeast strain of the Cystobasidium slooffiae species was detected, which indicates violations of sanitary and hygienic production. The issues of increasing the shelf life are especially relevant for confectionery products with intermediate moisture content (from 10 to 20%). The use of modified E1442 starch in the filling made it possible to reduce the content of yeast and mold during storage of gingerbread by 2–3 times compared to E1422 starch. For low moisture confectionery, when using lauric-type cocoa butter substitutes, there is a risk of a soapy taste due to the formation of free lauric acid under the action of lipolytic enzymes.
Socio-psychological analysis of the information security threats
Authors:   Ryazan State University named after S.A. Yesenin, Sukhov Anatoliy Nikolaevich
Published: June 2022

This article reveals the relevance of researching the information security problem and considers the essence of the socio-psychological approach to its understanding. This type of security is associated with a model for the information society development. Therefore, it is no coincidence that the most important task is to create a full-fledged information security theory. The article analyzes external and internal threats to information security. These include hacker attacks, break-ins, cyber interference, invasion of the national information system, cybercrime threats, information and psychological warfare, etc. In addition, the practice of overcoming these threats in order to ensure information security is analyzed. Without this, it is impossible to speak about the effective information security provision. This is achievable only by eliminating a number of negative consequences of the process of society informatization.
Suicidal behavior in adults during the pandemic: an individual psychological aspect
Authors:   FSBEI HE Kursk State University, Agronina Natalya Iosifovna , Gorbatenko Viktor Evgenievich ,   FSBEI HE Kursk State University
Published: June 2022

Suicidal behavior is one of the acute and primary problems of our society. Unfavorable political and socio-economic events constantly occurring in the society increase the feeling of fear and uncertainty about the future of each person. To this day, the causes and factors that push an adult to suicide are deeply studied by psychologists, sociologists, and psychiatrists, but it is too early to draw final conclusions. According to the World Health Organization, about 400–500 thousand people commit suicide every year, and the number of attempts is ten times higher. The number of suicides in European countries is about 3 times higher than the number of murders.
Ways of educating younger schoolchildren in the spirit of respect and love for spiritual values
Authors:   Nakhchivan State University, University campus, Nakhichevan, Abbaszade Zhalya Tofik gizi
Published: June 2022

This article examines the issues of using national values as a national idea in the classroom in primary school. Moral relations are built in different ways depending on the attitude of a person to society and the society requirements to him/her. The concept of national unity is an essential element of moral relations. These requirements are expressed in special forms of moral relations (duty, responsibility, dignity, honor, conscience, etc.). Each of those expresses the degree and method of moral control over one's moral activities. On the other hand, people form different relationships with each other, obey a common social discipline, follow traditions, mutually evaluate their actions (sanctions), influence others with their moral authority, compete with each other, participate in mass movements, etc. The possibility of forming moral consciousness in younger schoolchildren is precisely connected with instilling patriotism through the awareness of the national idea. This is possible through improving the learning process.
Reducing short-acting beta-agonist overprescribing in asthma: lessons from a quality-improvement prescribing project in East London
Authors: De Simoni Anna , Hajmohammadi Hajar , Pfeffer Paul , Cole Jim , Griffiths Chris , Hull Sally A
Published: June 2022

Background

Excess prescription and use of short-acting beta-agonist (SABA) inhalers is associated with poor asthma control and increased risk of hospital admission.

Aim

To quantify the prevalence and identify the predictors of SABA overprescribing.

Design and setting

A cross-sectional study using anonymised clinical and prescribing data from the primary care records in three contiguous East London boroughs.

Method

Primary care medical record data for patients aged 5–80 years, with ‘active’ asthma were extracted in February 2020. Explanatory variables included demography, asthma management, comorbidities, and prescriptions for asthma medications.

Results

In the study population of 30 694 people with asthma, >25% (1995/7980), were prescribed ≥6 SABA inhalers in the previous year. A 10-fold variation between practices (<6% to 60%) was observed in the proportion of patients on ≥6 SABA inhalers/year. By converting both SABAs and inhaled corticosteroids (ICSs) to standard units the accuracy of comparisons was improved across different preparations. In total, >25% of those taking ≥6 SABAs/year were underusing ICSs, this rose to >80% (18 170/22 713), for those prescribed <6 SABAs/year. Prescription modality was a strong predictor of SABA overprescribing, with repeat dispensing strongly linked to SABA overprescribing (odds ratio 6.52, 95% confidence interval = 4.64 to 9.41). Increasing severity of asthma and multimorbidity were also independent predictors of SABA overprescribing.

Conclusion

In this multi-ethnic population a fifth of practices demonstrate an overprescribing rate of <20% a year. Based on previous data, supporting practices to enable the SABA ≥12 group to reduce to 4–12 a year could potentially save up to 70% of asthma admissions a year within that group.
La dramatización como estrategia para fortalecer la autoestima en niños y niñas de la zona aimara
Authors: Ticona Arapa Haydee Clady , Zela Payi Nelly Olga , Avalos Gonzales Katty Mirella
Published: June 2022

El presente estudio tuvo como objetivo identificar la eficacia de la estrategia de la dramatización para fortalecer su autoestima, considerando las habilidades, cualidades, sentimientos que expresan cada niño y niña a través de la dramatización. Es de tipo experimental con diseño cuasi experimental considerando grupos intactos no aleatorios con pre y post prueba, donde las investigadoras manipulan la variable independiente (La dramatización como estrategia), así como medir el comportamiento de la variable dependiente (fortalecer la autoestima). En el estudio la muestra estuvo conformada por 20 niños (as); la técnica utilizada fue la observación, donde los resultados encontrados en el post test demuestran que el grupo experimental concluye en la escala valorativo es De Acuerdo, donde desarrollaron la autoestima relacionada consigo mismo (70%); en relación con los demás (75%) y frente a las tareas y obligaciones (65%).
Trabajo colegiado para contextualizar la planificación en modalidad no presencial
Authors: Zegarra Moreano Kattia Jackelin , Romero Huaylla Marcos Manuel , Olivares Rodríguez Pablo Celestino
Published: June 2022

El trabajo colegiado permite compartir ideas, experiencias, conocimientos y estrategias para contextualizar la planificación de aprendizajes en modalidad no presencial. El reto docente fue crear un ambiente de trabajo virtual. El estudio fue realizado en una institución educativa de Lima - Perú con el objetivo de conocer la importancia del trabajo colegiado para contextualizar la planificación de aprendizajes mediante la plataforma Edmodo. Se empleó la metodología de paradigma interpretativo, enfoque cualitativo y diseño fenomenológico hermenéutico; se recogieron las experiencias de cinco docentes utilizando la entrevista conversacional. La interpretación de los resultados arrojó que las reuniones de trabajo colegiado son necesarias para contextualizar la planificación de los aprendizajes en la modalidad no presencial; además los participantes reconocieron que la plataforma permitió lograr sus objetivos. En conclusión, el trabajo colegiado forma parte de la labor docente, además la planificación contextualizada es su producto más importante para lograr aprendizajes.
Intense Two-Octave Ultraviolet-Visible-Infrared Supercontinuum Laser via High-Efficiency One-Octave Second-Harmonic Generation
Authors: Li Mingzhou , Hong Lihong , Li Zhi-Yuan
Published: June 2022

Intense ultrabroadband laser source of high pulse energy has attracted more and more attention in physics, chemistry, biology, material science, and other disciplines. We report design and realization of a chirped periodically poled lithium niobate nonlinear crystal that supports ultrabroadband second-harmonic generation covering 350-850 nm by implementing simultaneously up to 12 orders of quasiphase matching against ultrabroadband pump laser covering 700-1700 nm with an average high conversion efficiency of about 25.8%. We obtain a flat supercontinuum spectrum with a 10 dB bandwidth covering more than one octave (about 375-1200 nm) and 20 dB bandwidth covering more than two octaves (about 350-1500 nm) in the ultraviolet-visible-infrared regime and having intense energy as 0.17 mJ per pulse through synergic action of second-order and third-order nonlinearity under pump of 0.48 mJ per pulse Ti:sapphire femtosecond laser. This scheme would provide a promising method for the construction of supercontinuum laser source with extremely broad bandwidth, large pulse energy, and high peak power for a variety of basic science and high technology applications.
Effects of kinship matings on embryo losses and hatch-weight in japanese quails
Authors: ERDEM Hakan , SAVAŞ Türker
Published: June 2022

Inbreeding, which is the mating of related individuals, increases homozygosity and leads to depression, especially in traits with low heritability. In this study, parent-offspring, full-sibling and half-sibling mating groups were formed and their effects on embryo loss and hatch weight were investigated. In the study, a total of 2130 fertile Japanese quail eggs were used. Embryo losses were divided into three periods; early period (first 5-day), middle period (6-12th days) and late period (13-17th days). It was observed that mating groups affect all traits subject of this study (P≤0.0001). The lowest hatchability of fertile eggs was observed in dam-male offspring mating (DM), while the highest was observed in half-sibling (HS) and control (C) matings (P≤0.05). However, the highest hatch-weight were found in eggs of DM matings (P≤0.05). DM has also the highest embryo losses for all periods (P≤0.05). Most of the embryo losses, except the half-sibling group, occurred in the early period.
IMPLEMENTATION OF CRM METHODS TO IMPROVE SALES QUALITY OF BUNUT SEBRANG UMI CLOTHING SHOP
Authors: Safitri Windi , Putra Guntur Maha , Yuma Febby Madonna
Published: June 2022

Along with the times, the business world is experiencing rapid development, especially in the business world, such as selling fashion products. Therefore, a good strategy is needed. In maintaining more advanced competitiveness, companies must develop information technology. Another thing that must be considered in making our business more advanced is the relationship with customers, which is also an important thing to always maintain, to manage good relationships with new customers or regular customers by using the Customer Relationship Management (CRM) method. The Customer Relationship Management (CRM) method can make it easier for Umi Clothing Store owners to retain existing customers and make it easier for shop owners to get new customers. The research method used in this research is qualitative research. This research will only utilize data obtained from the research location and input it without changing anything.
De emancipadas a invisibles: las mujeres guineanas en la producción intelectual del Instituto Nacional de Estudios e Investigación (INEP)
Authors: Godinho Gomes Patricia
Published: June 2022

Este texto fue publicado originalmente en portugués con el título “De emancipadas a invisíveis: as mulheres guineenses na produção intelectual do Instituto Nacional de Estudos e Pesquisa”, en el libro Coordinado por Patricia Godinho GOMES y Claúdio Alves Furtado (2017). Encontros e desencontros de lá e cá do lado do Atlântico. Mulheres africanas e afro-brasileira em perspectiva de gênero. Salvador, EDUFBA, pp. 27-45. La traducción estuvo a cargo de Natalia Cabanillas.
Pengaruh Umur dan Paritas dengan Penggunaan KB Suntik 1 Bulan
Authors: Susmita  , Helen Evelina Siringoringo
Published: June 2022

Keluarga Berencana atau KB yaitu mewujudkan keluarga berkualitas melalui promosi, perlindungan, dan bantuan dalam mewujudkan hak-hak reproduksi serta penyelenggaraan pelayanan, pengaturan, dan dukungan yang diperlukan untuk membentuk keluarga dengan usia kawin yang ideal, mengatur jumlah, jarak dan usia ideal melahirkan anak, mengatur kehamilan serta membina ketahanan dan kesejahteraan keluarga. Tujuan penelitian mengetahui pengaruh umur dan paritas dengan penggunaan KB suntik 1 bulan. Desain penelitian menggunakan metode survey analitik dengan rancangan penelitian cross sectional. Penelitian ini menggunakan data sekunder. Sampel penelitian berjumlah 86 responden. Tehnik Pengambilan sampel secara total sampling. Analisa yang digunakan univariat dan bivariat dengan uji Chi -Square. Hasil penelitian didapatkan umur (20 – 35 tahun) sebanyak 53 (61,6%), umur (< 20 dan > 35 tahun) sebanyak 33 (38,4%), paritas  ≤ 2 anak  sebanyak 46 (53,5%) dan paritas > 2 anak sebanyak 40 (46,5%). Hasil bivariat menunjukkan terdapat hubungan antara umur  (p = 0,002) dan paritas p = 0,000) dengan penggunaan KB suntik 1 bulan.
Agua potable un derecho de la humanidad: características fisicoquímicas, bacterias y metales pesados
Authors: Castillo Eveling , Medina Roxana , Zúñiga Higinio
Published: June 2022

Este libro es una adaptación de una investigación realizada en la Universidad Nacional del Altiplano, cuyo objetivo fue determinar la calidad fisicoquímica, bacteriológica, contenido de metales pesados y plantear alternativas de solución de agua poblado de la ciudad de Ilave (Puno, Perú). Metodología: Tomar muestras del punto de captación, depósito de bombas y reservorio según normas de muestreo estandarizadas, el pH se determinó mediante el método electrométrico, la dureza mediante el método titulométrico, los cloruros mediante el método Mohr, los sulfatos, los nitritos y los nitratos mediante espectrofotometría de absorción, los sólidos disueltos totales mediante Conductimetría, las bacterias mediante el número más probable y los metales pesados mediante espectrofotometría por absorción atómica todos ellos realizados en el Laboratorio de la DIRESA – Puno (Perú), los parámetros fueron contrastados con los establecidos en el D.S. 004 – 2017 del MINAM. Resultados: pH entre 8.05 y 794 unidades, dureza entre 174.62 y 160.67 mg/l de CaCO3, cloruros entre 143.61 y 111.72 mg/l, sulfatos entre 69.54 y 56.36 mg/l, nitritos entre 0.96 y 0.53 mg/l, sólidos totales disueltos entre 428.27 y 367.23 mg/l, turbidez entre 5.17 y 3.87 UNT, todos dentro de los rangos establecidos de los estándares de calidad de agua, excepto en el punto de captación, donde la turbidez y el recuento de CT superan los estándares, la carga bacteriana entre 46 NMP/100 ml y 23 NMP/100 ml; el contenido de metales está por debajo de lo indicado en las normas, excepto los iones plomo con 0.0842 mg/l. Alterantiva de solución: filtro con carbón activado impregnado con quitosano, el proceso de hervido y posterior sedimentación del agua, uso de minerales zeolíticos modificados, electrocoagulación, método de dos cubetas y remoción asistida por luz solar. Conclusión: El agua potable de Ilave cumple con la normatividad vigente con respecto a los parámetros fisicoquímicos, mientras tanto posee plomo por encima de lo establecido.
Görme Yetersizliği Olan Öğrencilere Kinetik Enerji ve Sıcaklık Kavramlarının Öğretimi
Authors: KIZILASLAN Aydın , SÖZBİLİR Mustafa
Published: June 2022

Görme yetersizliği olan öğrenciler, temel eğitime erişim noktasında pek çok sorunlar yaşamaktadır. Fen kavramlarının öğretiminde yaşanan sıkıntılar göz önünde bulundurulduğunda görme yetersizliği olan öğrencilerin fen kavramlarını daha iyi öğrenebilmeleri için uygun materyal ve etkinliğin geliştirilmesi bu etkinliklerin uygulanması ve değerlendirilmesi bu çalışmanın amacını oluşturmaktadır. Biri total kör beşi ise az gören olan toplam altı öğrenci bu çalışmanın örneklemini oluşturmaktadır. Nitel araştırma yaklaşımlarından durum çalışması kullanılarak yapılan çalışmada Fen Etkinlik Gözlem Formu (FEGF) veri toplama aracı olarak kullanılmıştır. Buna göre görme yetersizliği olan öğrencilere “Kinetik Enerji ve Sıcaklık” kavramının öğretimine yönelik geliştirilen fen etkinliğinin öğretim, öğrenme, işlevsellik ve kullanışlılık boyutlarında belirlenen gereksinimlerin çoğunu karşıladığı tespit edilmiştir.
Implementasi Algoritma Best First Search untuk Pencarian Rute Terpendek pada Aplikasi Cerdas Pendaftaran Santri Baru
Authors: Herfandi Herfandi , Soleha Ulfatus , Susilo Yuda Irawan Agung , Ahmad Baihaqi Kiki , Maulana Reza
Published: June 2022

Pesantren di Indonesia merupakan lembaga pendidikan islam tradisional yang mampu eksis sampai saat ini. Proses pendaftaran yang kurang terstruktur memungkikan kesalahan serta keterlambatan dalam proses pendaftaran santri baru akan mudah terjadi. Pondok Pesantren Manbaul Ulum dalam menjalankan proses administrasi pendidikan masih menggunakan cara konvensional hal ini menyebabkan sistem pelayanan yang digunakan belum efisien serta masalah keterbatasan asrama maka dibuatlah regulasi pendaftaran harus sesuai dengan zona jarak tempat tinggal yang telah ditentukan. Karenanya penelitian ini melakukan implementasi algoritma best first search untuk pencarian rute terpendek pada aplikasi cerdas pendaftaran santri baru. Penelitian ini menghasilkan aplikasi cerdas pendaftaran santri baru dengan menerapkan algoritma best first search. Metode pengembangan menggunakan waterfall. Pengujian perangkat lunak dengan metode black box testing dengan teknik test case equivalence partitioning mendapatkan kesimpulan berhasil dari berbagai jenis pengujian. Dengan fitur untuk santri yaitu data estimasi, home, petunjuk, contact us, mendaftar, login, mengisi formulir pendaftaran, lihat verifikasi, cetak bukti lulus, dan melihat tute terpendek, untuk admin setting tahun ajaran, lihat pendaftaran, lihat pendaftaran diterima dan ditolak serta melihat laporan. Sedangkan untuk superadmin yaitu CRUD data admin dan lihat laporan. Aplikasi ini diharapkan dapat membantu administrasi pesantren dan calon santri melihat rute serta mendukung pendidikan di era Industri 4.0.
Black Box Testing dengan Teknik Equivalence Partitions Pada Aplikasi Android M-Magazine Mading Sekolah
Authors: Novalia Elfina , Voutama Apriade
Published: June 2022

Pengujian aplikasi/software merupakan tahapan untuk memeriksa apakah suatu program berjalan dengan semestinya atau belum jika masih ada kesalahan maka harus diperbaiki sehingga program yang dibuat mencapai tujuan dan memiliki kualitas yang baik. Salah satu software yang perlu dilakukan pengujian yaitu aplikasi M-Magazine. M-Magazine adalah aplikasi berbasis android yang digunakan sebagai mading secara digital di Sekolah tingkat atas yang terdiri dari dua bagian yaitu berbasis Website sebagai panel admin dan berbasis mobile yang digunakan pada perangkat mobile user. Pengujian dilakukan menggunakan Black Box dengan teknik Equivalence Partitions.  Pengujian Black Box digunakan untuk melihat program dari sisi laur apakah sesuai dengan fungsi program tanpa mengetahui kode program sedangkan Teknik yang dipakai yaitu Equivalence Partitions merupakan teknik pengujian berdasarkan masukkan data disetiap form atau halaman dari aplikasi M-Magazine setiap masukan nilai akan diuji dan dikelompokkan sesuai test case dengan hasil bernilai bernilai valid ataupun tidak valid. Tujuan adanya pengujian pada Aplikasi M-Magazine ini untuk mendekteksi dan meminilisir kegagalan saat diimplementasikan sehingga kesalahan ditemukan dapat diperbaiki lebih cepat.
The Importance of College Reading
Authors: Hollander Pam , Dawson Duke , Haller Charlotte , Briesacher Erika , Collins Caroline , Rearick Kristina , Lemieux Elise
Published: June 2022

Professors and students have contradictory views of course reading. Professors believe that reading outside of the classroom is essential in optimizing learning. However, students often find the readings to be time-consuming, not necessary to pass the class, and an option rather than a requirement. We surveyed 449 undergraduate university students and interviewed 17 university faculty to determine the perceived value of reading assignments in college classes. This preliminary study yielded that faculty could benefit from professional development workshops that will help them determine how to incorporate strategies to increase the students’ completion of assigned readings. By investigating students’ thoughts and concerns, professors can better understand how to make assigned readings more attractive to students.
Crossword Puzzles and Knowledge Retention
Authors: Torres Elisa R. , Williams P. Renée , Kassahun-Yimer Wondwosen , Gordy Xiaoshan Zhu
Published: June 2022

Students perceive crossword puzzles as enjoyable. In addition to students’ perceptions, crossword puzzles actually improve knowledge retention. However, crossword puzzles increased exam scores for some students but not others. Recommendations have been made for students to create puzzles for their classmates to complete with the rationale that students are encouraged to research and understand the material in order to write meaningful clues for the puzzle. While students enjoy creating their own crossword puzzles, the association between students creating crossword puzzles and knowledge retention is unknown. The purpose of this project was to determine if creating crossword puzzles and completing peers’ crossword puzzles were associated with improved knowledge retention indicated by higher scores on quizzes. Students in a research course from two institutions across three semesters had the option each week to upload a blank puzzle they created prior to completing each other’s puzzles and taking a quiz. Quiz scores were compared between those who did versus did not create their own puzzles and complete their peers’ puzzles. Results varied by institution and programs as well as the same program within the same institution but different semesters. Results highlight the importance of moving beyond student perceptions and towards assessing knowledge retention while taking into consideration institution, program, and semester.
АНАЛІЗ ТЕНДЕНЦІЙ РОЗВИТКУ РИНКУ ТЕЛЕКОМУНІКАЦІЙНИХ ПОСЛУГ В УКРАЇНІ
Authors: Грицуленко Світлана , Толкачова Галина
Published: June 2022

Успішний розвиток сучасної економіки у багатьом визначається активним розвитком сфери телекомунікацій, інноваційні перетворення якої відбуваються в глобальному масштабі по всіх країнах світу. Завдяки величезному попиту на галузеві інновації, телекомунікаційний ринок – один із динамічніших у світовій економіці; він щорічно нарощує свою частку у глобальному ВВП.
ОСОБЛИВОСТІ ПІДПРИЄМНИЦТВА У СФЕРІ ХАРЧОВИХ ТЕХНОЛОГІЙ У ПЕРІОД ВОЄННОГО СТАНУ: РЕЛОКЕЙТ ПІДПРИЄМСТВ
Authors: Недошитко Ангеліна , Яремко Ірина
Published: June 2022

Розглянуто можливості ведення підприємницької діяльності у харчовій сфері в сучасних воєнних умовах. Досліджено можливі і адекватні до цих умов основні напрямки вироблення державно-приватної політики розвитку та відбудови національної економіки. Виділено основні проблемні фактори для стабільної діяльності підприємств галузі харчових технологій. Обґрунтовано важливість виокремлення особливостей функціонування підприємництва у досліджуваній галузі та аргументовано їх значимість для формулювання нових підходів до регулювання діяльності підприємств харчових технологій у поточних умовах та поступової адаптації до умов повоєнної відбудови економіки. Доведено важливість своєчасного вироблення адаптивних засад державної регуляції і механізмів побудови раціональних принципів та підходів до організації підприємництва в галузі. Встановлено, шо через географічні чинники ведення бойових дій багато підприємств не мають можливість безпечної роботи на територіях сходу та півночі України. Обґрунтовано актуальність формулювання базових засад організації міжобласного релокейту бізнесу в територіальних межах країни. Визначено, що релокація підприємництва досліджуваної галузі в територіальних межах держави є реальним напрямом втримати функціонування бізнесу цієї сфери, відновити досяжний рівень його стабільності в обмежених воєнних умовах. Запропоновано при реалізації процесів релокації урахувати особливості регіону, кількість економічно зайнятого населення та інші показники, які можуть впливати на роботу структурних підрозділів суб’єктів харчової промисловості. При практичному впровадженні цих процесів стратегічно потрібно починати з вибору місця та способу переїзду, оскільки нове приміщення та його структура бізнесу можуть стати надійною основою для його повоєнного відновлення та розвитку. Відзначено актуальність вирішення під час релокейту питань розміщення та створення умов для працівників, що евакуйовуються разом з підприємством.
IMPLICIT REFLECTIONS OF RUSSIA-UKRAINE WAR IN ARABIC INTERNET MEMES
Authors: Kucherenko Alina
Published: June 2022

The reaction to the news of Russian invasion of Ukraine is expressed in the Arab world through various communicative means, including Internet memes. Language of social media is utilised to convey the non-official public opinion, both explicitly and implicitly. This paper deals with a complex study of the Arabic humorous discourse, in particular Ukraine war memes, involving their linguistic, sociolinguistic, and pragmatic peculiarities. The research is based on the works of R. Bassiouney [1], M. Bulatovic [2], M. R. Enverga [3], and others. Arabic narratives about the Russian war against Ukraine on social networks have been outlined in the Ukrainian mass media [4]. However, a more in-depth linguistic analysis is necessary to examine the language as a tool affecting the public opinion online.
АНТИФОСФОЛІПІДНИЙ СИНДРОМ В МЕДИЧНІЙ ПРАКТИЦІ
Authors: Фартушок Тетяна , Фартушок Надія , Флуд Вадим , Козловська Христина , Думанчук Наталя
Published: June 2022

Антифосфоліпідний синдром характеризується венозним та артеріальним тромбозом і тяжкими ускладненнями, що призводять до частих летальних наслідків. Продукція антифосфоліпідних антитіл (антикардіоліпінові антитіла, антитіла до β2 -глікопротеїну I та вовчакові антитіла) сприяє ушкодженню ендотелію судинної стінки, що запускає механізм гіперкоагуляції та тромбоутворення під впливом зовнішніх чинників. Антифосфоліпідні антитіла можуть сприяти розвитку дисфункції органів через механізми імунної відповіді та системи гемостазу, пов’язані між собою.
Anderson-Fabry Disease: A Disease with Polymorphic Cardiac Involvement
Authors: Benchekroun Y. , Zniber K. , Bennani M. , Bouzelmat H. , Chaib A. , Benyass A.
Published: June 2022

Fabry disease (FD) is an under-recognized X-linked recessive lysosomal storage disorder resulting from the deficient activity of the enzyme α-galactosidase A (α-Gal A). This 65 year-old male was follow-up in dermatology department since 1972 for angiokeratoma corporis. He was being explored for cardiac symptoms : dyspnea and atypical chest pain. His echocardiography revealed hypertrophic cardiomyopathy initially, and his coronarography was normal. The diagnosis of Fabry disease was evoked clinically and then confirmed by deficiency of alpha-galactosidase α-Gal A activity. The evolution was marked by aggravtion of cardiac symptoms, frequent hospitalisations for heart failure related to dilated cardiomyopathy with severe left ventricular dysfunction, arrythmias, a renal failure, and cerebrovascular events. This case illustrates the rich manifestations of this disease and the polymorphism of cardiac involvement that can lead to fatal complications and poor prognosis. FD is treatable with specific treatment. Therefore, the early diagnosis of this disease is important for ameliration of the morbidity and mortality.
The Functional Outcome of Single Stage Multi-Level Surgery of Spastic Cerebral Palsy
Authors: Khalequzzaman Dr. AKM , Aslam Dr. Mohiuddin , Salam Professor Sarwar Ibn
Published: June 2022

Introduction: Cerebral palsy is a heterogeneous disorder that makes the child handicapped. The incidence is about 2 per 1000 live births with the highest rates in premature babies and those of multiple births. It should be treated in a multi-disciplinary approach with the combination of a pediatrician, neurologist, or orthopaedic surgeon & physiotherapist. Aim of the study: The aim of the study was to assess the outcome of single-stage multilevel surgery of spastic Cerebral Palsy (CP). Methods: This prospective Experimental Study (quasi experimental Study) was conducted from July 2012 to June 2014 at the Department of Orthopaedics, Dhaka Medical College Hospital, and different clinics in Dhaka city. Twenty patients with diplegic and hemiplegic spastic cerebral palsy were recorded. Preoperative and post operative GMFCS and gait pattern of each patient were recorded for evaluation of results. Among them 12-patient were diplegic and 08 patients were hemiplegic. Data was collected and recorded sequentially and analyzed by SPSS computer software program, version 20 and MS-Excel 2016. Results: Mean follow up time was 13 months. There were 15 (75%) excellent, 5 (25%) good results assessed clinically by comparing preoperative and post operative gait pattern and GMFCS scoring system. Complications including superficial skin infection in 4 cases. There was no recurrence. Conclusion: Single-stage multilevel soft-tissue surgery in the lower limb(s) in children with spastic CP yields good results for locomotion and good trunk control.
Idiopathic Encapsulating Peritonitis as Unusual Cause of Bowel Obstruction Discovered Intraoperative: A Case Report
Authors: Houba Abdelhafid , Doghmi Nawfal
Published: June 2022

Idiopathic sclerosing encapsulating peritonitis (SEP) is a rare cause of intestinal obstruction that is characterized by total or patial encasement of the intestines by a fibrocollagenous coccon-like a membrane. Early clinical features of this condition are generally non-specific and are frequently not recognized until the patient develops signs of small bowel obstruction. We report the observation of an adult patient operated for an acute bowel obstruction, in which the diagnosis of sclerosing encapsulating peritonitis (SEP) was made intraoperative. A good understanding of SEP and a better awareness of its clinical, paraclinical and therapeutic findings may aid to establish better management of this rare condition.
Clival Chondroma with Brainstem Invasion Findings in MRI: A Case Report
Authors: Chahbi Zakaria , Wakrim Soukaina
Published: June 2022

Chordoma is a rare neoplasm derived from remnants of the fetal notochord; the most commun locations are the lumbosacral spineand the clivus. Clival chordomas represent 35 to 40% of cases and are very difficult to treat because of the localization and high recurrence rate. We present the case of 60 years old male patient with no previous history consulting for diplopia and headach that worsened in the last week before the diagnosis, with a walking ability disorder. Neurological examination found a raised intracranial pressure syndrome with static cerebellar syndrome. However, he presented left hemifacial numbness due to left fifth cranial nerve palsy and diplopia at left gaze due to left sixth cranial nerve palsy. The diagnosis was made by MRI using the different sequences especially T1 SE, T1 GE, T2 FLAIR, DWI and spectroscopy.
Biliary Cystadenocarcinoma Misdiagnosed As a Hydatic Cyst of the Liver: About A Case and Literature Review
Authors: Mahdaouy Youssef El , Njoumi Noureddine , Fahssi Mohammed El , Yaka Mbarek , Hjouji Abderrahman , Ali et Abdelmounaim Ait
Published: June 2022

Biliary cystadenocarcinomas are very rare malignant epithelial tumours of the liver. The preoperative diagnosis of this cystic tumor is difficult because its clinical and radiological presentation is non-specific. Complete surgical removal is the recommended treatment for hepatic cystadenocarcinoma. Incomplete resection is a source of tumor recurrence and metastatic dissemination, which is the case when it is wrongly diagnosed as another benign cystic lesion of the liver. We report a new case of biliary cystadenocarcinoma that has been diagnosed as a hepatic hydatic cyst, resulting in inadequate management.
Acute Respiratory Distress Syndrome Secondary to Eosinophilic Pneumonia: A Case Report
Authors: Houba Abdelhafid , Fjouji Salaheddine , Kartite Noureddine , Bakkali Hicham , Doghmi Nawfal
Published: June 2022

We report a case of acute respiratory distress syndrome (ARDS) in a 26-year-old women. Hypoxemia was refractory despite conventional treatment of ARDS, but the evolution was satisfactory after corticosteroid therapy. Boiological data, results on bronchoalveolar lavage and the clinical evolution led us to the diagnosis of acute eosinophilic pneumonia. This case demonstrates that acute eosinophilic pneumonia should be included in rigorous etiological research before any ARDS, in order to start the appropriate treatment as soon as possible.