bluuebunny/crossref_metadata_2025 huggingface dataset:
The Assessment of Cooking Skills and Food Skills and Their Relationship with Nutrition Knowledge, Attitude toward a Healthy Diet and Food Intake: Results of a German Validation Study
Authors: Mötteli Sonja , Hotzy Florian
Published: August 2022

There is a lack of validated assessment instruments that capture all facets of cooking skills (CS) and food skills (FS). The goal of this study was to validate the German version of a questionnaire to assess a broad range of CS and FS and to examine its relationship with nutrition knowledge, attitude toward a healthy diet, and food intake. The German version was developed using forward–backward translation. An online survey was completed by students (n = 141), participants from the general Swiss population (n = 50), and nutrition experts (n = 18), including the CS and FS items along with nutrition knowledge, food frequency items, attitude toward a healthy diet and sociodemographic variables. The reliability and construct validity were examined. Results: For all of the samples, Cronbach’s alpha was between 0.85 and 0.88 for CS items and between 0.84 and 0.86 for FS items. The scales were strongly correlated (r = 0.60–0.77, p < 0.01). Nutrition experts showed higher confidence in their CS and FS than students and the participants of the general Swiss population (p < 0.001). CS and FS correlated weakly to moderately with practical nutrition knowledge, attitude toward a healthy diet, and the diet quality index. The German version is an efficient, valid, and highly reliable instrument that seems sensitive to changes. FS, compared to CS, might be more important for a healthy diet.
Association between Coronary Artery Plaque Progression and Liver Fibrosis Biomarkers in Population with Low Calcium Scores
Authors: Tsai Tsung-Ying , Hsu Pai-Feng , Wu Cheng-Hsueh , Huang Shao-Sung , Chan Wan-Leong , Lin Shing-Jong , Chen Jaw-Wen , Lu Tse-Min , Leu Hsin-Bang
Published: August 2022

Background: The severity of nonalcoholic fatty liver disease (NAFLD) has been found to be associated with atherosclerosis burden. However, whether liver fibrosis scores can be used to predict atherosclerosis progression, especially for patients with low calcium scores, remains undetermined. Methods: A total of 165 subjects who underwent repeated coronary computed tomography angiography (CCTA) and had low calcium scores (<100) were enrolled. The segment stenosis score (SSS) from the CCTA was measured, and the association between SSS progression and biochemical parameters was analyzed in addition to liver fibrosis scores, including nonalcoholic fatty liver disease fibrosis score (NFS), fibrosis-4 index (FIB-4), aspartate aminotransferase (AST) to platelet ratio index (APRI), and Forns score. Results: When compared with those without plaque at baseline (SSS = 0), subjects with plaque had higher blood pressure, higher coronary artery calcium (CAC) scores, and higher liver fibrosis scores, including Forns score, Fib-4, and NFS. During the medium follow-up interval of 24.7 months, 60 (39.4%) patients displayed SSS progression, while the remaining 105 (63.6%) patients showed no CAD progression. In a multivariate analysis, being male having a high diastolic blood pressure (DBP), and having a high NFS liver fibrosis score were independently associated with the odds ratio for SSS progression. Conclusions: Higher baseline blood pressure and liver fibrosis markers are associated with the presence of coronary artery disease (CAD) plaques in subjects in early CAD stages. For disease progression, the male gender, DBP, and NFS appear to be independently associated with coronary atherosclerosis plaque progression in subjects with low calcium scores.
Omega-9 Modifies Viscoelasticity and Augments Bone Strength and Architecture in a High-Fat Diet-Fed Murine Model
Authors: Omer Mahmoud , Ali Hessein , Orlovskaya Nina , Ballesteros Amelia , Cheong Vee San , Martyniak Kari , Wei Fei , Collins Boyce E. , Yarmolenko Sergey N. , Asiatico Jackson , Kinzel Michael , Ngo Christopher , Sankar Jagannathan , Calder Ashley , Gilbertson Timothy , Meckmongkol Teerin , Ghosh Ranajay , Coathup Melanie
Published: August 2022

The influence of diet on the development of osteoporosis is significant and not fully understood. This study investigated the effect of diets of varying lipid profiles and ω-3, ω-6 and ω-9 composition on the structural and mechanical properties of bone. The hypothesis studied was that a diet high in saturated fat would induce osteoporosis and produce an overall increased detrimental bony response when compared with a diet high in unsaturated ω-6, or ω-9. Male C57BL/6J mice were fed either a control diet, 50:50 mix (saturated:unsaturated) high in ω-9 (HFD50:50), a diet high in saturated fat (HSF) or a polyunsaturated fat diet high in ω-6 (PUFA) over an 8-week duration. Tibiae were retrieved and evaluated using DMA, 3-point-bending, histomorphometry, and microCT. Mice fed a HSF diet displayed key features characteristic of osteoporosis. The loss tangent was significantly increased in the HFD50:50 diet group compared with control (p = 0.016) and PUFA-fed animals (p = 0.049). HFD50:50-fed mice presented with an increased viscous component, longer tibiae, increased loss modulus (p = 0.009), and ultimate stress, smaller microcracks (p < 0.001), and increased trabecular width (p = 0.002) compared with control animals. A diet high in ω-9 resulted in an overall superior bone response and further analysis of its role in bone health is warranted.
Antibiotics and Carbohydrate-Containing Drugs Targeting Bacterial Cell Envelopes: An Overview
Authors: Riu Federico , Ruda Alessandro , Ibba Roberta , Sestito Simona , Lupinu Ilenia , Piras Sandra , Widmalm Göran , Carta Antonio
Published: August 2022

Certain bacteria constitute a threat to humans due to their ability to escape host defenses as they easily develop drug resistance. Bacteria are classified into gram-positive and gram-negative according to the composition of the cell membrane structure. Gram-negative bacteria have an additional outer membrane (OM) that is not present in their gram-positive counterpart; the latter instead hold a thicker peptidoglycan (PG) layer. This review covers the main structural and functional properties of cell wall polysaccharides (CWPs) and PG. Drugs targeting CWPs are discussed, both noncarbohydrate-related (β-lactams, fosfomycin, and lipopeptides) and carbohydrate-related (glycopeptides and lipoglycopeptides). Bacterial resistance to these drugs continues to evolve, which calls for novel antibacterial approaches to be developed. The use of carbohydrate-based vaccines as a valid strategy to prevent bacterial infections is also addressed.
Cholesterol-Lowering Effects of Asperidine B, a Pyrrolidine Derivative from the Soil-Derived Fungus Aspergillus sclerotiorum PSU-RSPG178: A Potential Cholesterol Absorption Inhibitor
Authors: Ontawong Atcharaporn , Duangjai Acharaporn , Sukpondma Yaowapa , Tadpetch Kwanruthai , Muanprasat Chatchai , Rukachaisirikul Vatcharin , Inchai Jakkapong , Vaddhanaphuti Chutima S.
Published: August 2022

Isolated secondary metabolites asperidine B (preussin) and asperidine C, produced by the soil-derived fungus Aspergillus sclerotiorum PSU-RSPG178, were found to exhibit inhibitory effects against 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase and oxidative stress in an in vitro assay. Whether or not the known pyrrolidine asperidine B and the recently isolated piperidine asperidine C have lipid-lowering effects remains unknown. Thus, this study aimed to investigate the hypocholesterolemic effects of asperidines B and C and identify the mechanisms involved in using in vitro, ex vivo, and in vivo models. The results show that both compounds interfered with cholesterol micelle formation by increasing bile acid binding capacity, similar to the action of the bile acid sequestrant drug cholestyramine. However, only asperidine B, but not asperidine C, was found to inhibit cholesterol uptake in Caco-2 cells by up-regulating LXRα without changing cholesterol transporter NPC1L1 protein expression. Likewise, reduced cholesterol absorption via asperidine-B-mediated activation of LXRα was also observed in isolated rat jejunal loops. Asperidine B consistently decreases plasma cholesterol absorption, similar to the effect of ezetimibe in rats. Therefore, asperidine B, the pyrrolidine derivative, has therapeutic potential to be developed into a type of cholesterol absorption inhibitor for the treatment of hypercholesterolemia.
Efficacy and Safety of Trametinib in Neurofibromatosis Type 1-Associated Plexiform Neurofibroma and Low-Grade Glioma: A Systematic Review and Meta-Analysis
Authors: Wang Dun , Ge Lingling , Guo Zizhen , Li Yuehua , Zhu Beiyao , Wang Wei , Wei Chengjiang , Li Qingfeng , Wang Zhichao
Published: August 2022

Trametinib has been used in neurofibromatosis type 1 (NF1) patients, especially those with unresectable nerve tumors, but no systematic review based on the latest studies has been published. We conducted this meta-analysis to evaluate the effectiveness and safety of trametinib in treating NF1-related nerve tumors. Original articles reporting the efficacy and safety of trametinib in NF1 patents were identified in PubMed, EMBASE, and Web of Science up to 1 June 2022. Using R software and the ‘meta’ package, the objective response rates (ORRs) and disease control rates (DCRs) were calculated to evaluate the efficacy, and the pooled proportion of adverse events (AEs) was calculated. The Grading of Recommendations, Assessment, Development and Evaluation system was used to assess the quality of evidence. Eight studies involving 92 patients were included, which had a very low to moderate quality of evidence. The pooled ORR was 45.3% (95% CI: 28.9–62.1%, I2 = 0%), and the DCR was 99.8% (95% CI: 95.5–100%, I2 = 0%). The most common AEs was paronychia, with a pooled rate of 60.7% (95% CI: 48.8–72.7%, I2 = 0%). Our results indicate the satisfactory ability to stabilize tumor progression but a more limited ability to shrink tumors of trametinib in NF1-related nerve tumors. The safety profile of trametinib is satisfactory.
Barium Oxide Doped Magnesium Silicate Nanopowders for Bone Fracture Healing: Preparation, Characterization, Antibacterial and In Vivo Animal Studies
Authors: Mabrouk Mostafa , Ibrahim Fouad Ghadha , Beherei Hanan H. , Das Diganta Bhusan
Published: August 2022

Magnesium silicate (MgS) nanopowders doped with barium oxide (BaO) were prepared by sol-gel technique, which were then implanted into a fracture of a tibia bone in rats for studying enhanced in vivo bone regeneration. The produced nanopowders were characterized using X-ray diffraction (XRD), Fourier transform infrared spectra (FTIR), scanning electron microscope with energy-dispersive X-ray spectrometry (SEM-EDX) and transmission electron microscope (TEM). Mechanical and bactericidal properties of the nanopowders were also determined. Increased crystallinity, particle diameter and surface area were found to decrease after the BaO doping without any notable alterations on their chemical integrities. Moreover, elevated mechanical and antibacterial characteristics were recognized for higher BaO doping concentrations. Our animal studies demonstrated that impressive new bone tissues were formed in the fractures while the prepared samples degraded, indicating that the osteogenesis and degradability of the BaO containing MgS samples were better than the control MgS. The results of the animal study indicated that the simultaneous bone formation on magnesium biomaterial silicate and barium MgS with completed bone healing after five weeks of implantations. The findings also demonstrated that the prepared samples with good biocompatibility and degradability could enhance vascularization and osteogenesis, and they have therapeutic potential to heal bone fractures.
Real-Life Therapeutic Concentration Monitoring of Long-Acting Cabotegravir and Rilpivirine: Preliminary Results of an Ongoing Prospective Observational Study in Switzerland
Authors: Thoueille Paul , Alves Saldanha Susana , Schaller Fabian , Munting Aline , Cavassini Matthias , Braun Dominique , Günthard Huldrych F. , Kusejko Katharina , Surial Bernard , Furrer Hansjakob , Rauch Andri , Ustero Pilar , Calmy Alexandra , Stoeckle Marcel , Battegay Manuel , Marzolini Catia , Andre Pascal , Guidi Monia , Buclin Thierry , Decosterd Laurent A. ,   on behalf of the Swiss HIV Cohort Study
Published: August 2022

SHCS#879 is an ongoing Switzerland-wide multicenter observational study conducted within the Swiss HIV Cohort Study (SHCS) for the prospective follow-up of people living with HIV (PLWH) receiving long-acting injectable cabotegravir-rilpivirine (LAI-CAB/RPV). All adults under LAI-CAB/RPV and part of SHCS are enrolled in the project. The study addresses an integrated strategy of treatment monitoring outside the stringent frame of controlled clinical trials, based on relevant patient characteristics, clinical factors, potential drug-drug interactions, and measurement of circulating blood concentrations. So far, 91 blood samples from 46 PLWH have been collected. Most individuals are less than 50 years old, with relatively few comorbidities and comedications. The observed concentrations are globally in accordance with the available values reported in the randomized clinical trials. Yet, low RPV concentrations not exceeding twice the reported protein-adjusted 90% inhibitory concentration have been observed. Data available at present confirm a considerable between-patient variability overall. Based on the growing amount of PK data accumulated during this ongoing study, population pharmacokinetic analysis will characterize individual concentration-time profiles of LAI-CAB/RPV along with their variability in a real-life setting and their association with treatment response and tolerability, thus bringing key data for therapeutic monitoring and precision dosage adjustment of this novel long-acting therapy.
In Vitro Interactions of Amphiphilic Phosphorous Dendrons with Liposomes and Exosomes—Implications for Blood Viscosity Changes
Authors: Veliskova Martina , Zvarik Milan , Suty Simon , Jacko Juraj , Mydla Patrick , Cechova Katarina , Dzubinska Daniela , Morvova Marcela , Ionov Maksim , Terehova Maria , Majoral Jean-Pierre , Bryszewska Maria , Waczulikova Iveta
Published: August 2022

Drug delivery by dendron-based nanoparticles is widely studied due to their ability to encapsulate or bind different ligands. For medical purposes, it is necessary (even if not sufficient) for these nanostructures to be compatible with blood. We studied the interaction of amphiphilic dendrons with blood samples from healthy volunteers using standard laboratory methods and rheological measurements. We did not observe clinically relevant abnormalities, but we found a concentration-dependent increase in whole blood viscosity, higher in males, presumably due to the formation of aggregates. To characterize the nature of the interactions among blood components and dendrons, we performed experiments on the liposomes and exosomes as models of biological membranes. Based on results obtained using diverse biophysical methods, we conclude that the interactions were of electrostatic nature. Overall, we have confirmed a concentration-dependent effect of dendrons on membrane systems, while the effect of generation was ambiguous. At higher dendron concentrations, the structure of membranes became disturbed, and membranes were prone to forming bigger aggregates, as visualized by SEM. This might have implications for blood flow disturbances when used in vivo. We propose to introduce blood viscosity measurements in early stages of investigation as they can help to optimize drug-like properties of potential drug carriers.
Targeting Myocardial Fibrosis—A Magic Pill in Cardiovascular Medicine?
Authors: Scridon Alina , Balan Alkora Ioana
Published: August 2022

Fibrosis, characterized by an excessive accumulation of extracellular matrix, has long been seen as an adaptive process that contributes to tissue healing and regeneration. More recently, however, cardiac fibrosis has been shown to be a central element in many cardiovascular diseases (CVDs), contributing to the alteration of cardiac electrical and mechanical functions in a wide range of clinical settings. This paper aims to provide a comprehensive review of cardiac fibrosis, with a focus on the main pathophysiological pathways involved in its onset and progression, its role in various cardiovascular conditions, and on the potential of currently available and emerging therapeutic strategies to counteract the development and/or progression of fibrosis in CVDs. We also emphasize a number of questions that remain to be answered, and we identify hotspots for future research.
A New Control Strategy for High-Pressure Homogenization to Improve the Safety of Injectable Lipid Emulsions
Authors: Grumbach Carsten , Krüger Volker , Czermak Peter
Published: August 2022

Intravenous lipid emulsions are biocompatible formulations used as clinical nutrition products and lipid-based delivery systems for sparingly soluble drugs. However, the particle-size distribution is associated with risks of embolism. Accordingly, the mean particle diameter (MPD) and particle-distribution tailing (characterized as the pFAT5 value) are critical quality attributes that ensure patient safety. Compliance with the limits stated in the United States Pharmacopoeia is ensured by high-pressure homogenization, the final step of the manufacturing process. The US Food and Drug Administration’s Quality-by-Design approach requires a control strategy based on deep process understanding to ensure that products have a consistent and predefined quality. Here we investigated the process parameters of a jet-valve high-pressure homogenizer, specifically their effect on the MPD, pFAT5 value and droplet count (determined by microscopy) during the production of a Lipofundin MCT/LCT 20% formulation. We provide deep insight into droplet breakup and coalescence behavior when varying the process pressure, emulsion temperature and number of homogenization cycles. We found that high shear forces are not required to reduce the pFAT5 value of the particle distribution. Finally, we derived a control strategy for a rapid and cost-efficient two-cycle process that ensures patient safety over a large control space.
Calibration of an RF/Microwave Phase Noise Meter with a Photonic Delay Line
Authors: Lavrič Andrej , Batagelj Boštjan , Vidmar Matjaž
Published: August 2022

The main advantage of phase noise meters with photonic (fiber) delay lines is that they do not require high-performance, low-noise reference oscillators. On the other hand, some additional calibrations are required, which are the subject of this paper. First, the quadrature must be maintained on the mixer by precise adjustment of the phase and/or delay. Next, since the response of the mixer is proportional to the square of the input test signal, a precise amplitude calibration is required. Finally, the frequency response of the FFT spectrum analyzer and its corresponding anti-aliasing low-pass filter needs to be known precisely. In this paper, to the best of our knowledge, we present innovative solutions for all three calibrations. All three calibrations were built in and tested in our phase noise meter. The result is a simple and robust phase noise meter suitable for non-laboratory environments.
Design Method of Freeform Off-Axis Multi-Mirror Optical Systems
Authors: Liu Xinyu , Zhu Jun
Published: August 2022

A data point calculation method that does not require the use of Fermat′s principle and a simple and general design method of starting points of freeform off-axis multi-mirror optical systems are proposed in this paper, which aim to promote the realization of high-performance reflective systems containing freeform surfaces. Taking a planar system and the required parameters as the input, a good starting point for a freeform off-axis multi-mirror system can be automatically obtained using the proposed method. The design of a freeform off-axis five-mirror system with a low F-number is taken as an example to show the effectiveness of the proposed method. The method can also be used for the design of freeform reflective systems with other numbers of mirrors.
Optimization of VGG16 Algorithm Pattern Recognition for Signals of Michelson–Sagnac Interference Vibration Sensing System
Authors: Cheng Jing , Song Qiuheng , Peng Hekuo , Huang Jingwei , Wu Hongyan , Jia Bo
Published: August 2022

Signal recognition accuracy and recognition time are the two most important parameters of pattern recognition in a fiber optic vibration sensing system. To obtain high recognition accuracy and short recognition time, this paper optimized the VGG16 algorithm and carried out VGG16-1D and VGG16-2D recognition on big data signals generated by a Michelson–Sagnac interferometric vibration sensor system. The results indicate that VGG16-1D has a higher accuracy of 98.44% and a shorter recognition time of 0.03 s. The proposed method is a more accurate and faster pattern recognition method for big data signals from optical fiber vibration sensing systems, which is helpful in promoting further applications of optical fiber sensing systems.
Flexible Zoom Telescopic Optical System Design Based on Genetic Algorithm
Authors: Liu Zhaoyang , Hong Huajie , Gan Zihao , Chen Yaping , Xing Kunsheng
Published: August 2022

The performance of current liquid zoom systems is severely limited by their initial structure’s construction and solution. In this study, an automatic search method based on genetic algorithm (GA) was proposed for obtaining the optimal initial structure of a double liquid lens zoom optical system. This method was used to design a zoom telescopic objective with a fast response characteristic. The zoom equation of the zoom system was derived based on the Gaussian bracket method, and an initial structure evaluation function that integrated the aberration, the system length, and the smoothness of the focal power change in the liquid lenses was designed. This evaluation function was used as the fitness function in GA to automatically retrieve the optimal initial structure of the zoom system. Finally, an optical design software was used to optimize the design of the zoom system to obtain the final structure of the zoom system. Image quality analysis and tolerance analysis of the zoom system revealed that the system exhibited excellent imaging capability and could be manufactured easily. In addition, the analysis of the zoom curve revealed that the optical system exhibited a smooth continuous zooming capability.
Mechano-Chemical Properties of Electron Beam Irradiated Polyetheretherketone
Authors: Almas Nurlan , Kurbanova Bayan , Zhakiyev Nurkhat , Rakhadilov Baurzhan , Sagdoldina Zhuldyz , Andybayeva Gaukhar , Serik Nurzhan , Alsar Zhanna , Utegulov Zhandos , Insepov Zinetula
Published: August 2022

In this study, the mechano-chemical properties of aromatic polymer polyetheretherketone (PEEK) samples, irradiated by high energy electrons at 200 and 400 kGy doses, were investigated by Nanoindentation, Brillouin light scattering spectroscopy and Fourier-transform infrared spectroscopy (FTIR). Irradiating electrons penetrated down to a 5 mm depth inside the polymer, as shown numerically by the monte CArlo SImulation of electroN trajectory in sOlids (CASINO) method. The irradiation of PEEK samples at 200 kGy caused the enhancement of surface roughness by almost threefold. However, an increase in the irradiation dose to 400 kGy led to a decrease in the surface roughness of the sample. Most likely, this was due to the processes of erosion and melting of the sample surface induced by high dosage irradiation. It was found that electron irradiation led to a decrease of the elastic constant C11, as well as a slight decrease in the sample’s hardness, while the Young’s elastic modulus decrease was more noticeable. An intrinsic bulk property of PEEK is less radiation resistance than at its surface. The proportionality constant of Young’s modulus to indentation hardness for the pristine and irradiated samples were 0.039 and 0.038, respectively. In addition, a quasi-linear relationship between hardness and Young’s modulus was observed. The degradation of the polymer’s mechanical properties was attributed to electron irradiation-induced processes involving scission of macromolecular chains.
Highly Permeable Sulfonated Graphene-Based Composite Membranes for Electrochemically Enhanced Nanofiltration
Authors: Wang Junjie , Li Mingyu , Wei Gaoliang
Published: August 2022

A sulfophenyl-functionalized reduced graphene oxide (SrGO) membrane is prepared. The SrGO membranes have a high charge density in water and could provide many atomically smooth nanochannels, because of their strong ionized-SO3H groups and low oxygen content. Therefore, the SrGO membranes have an excellent performance in terms of high permeance and high rejection ability. The permeance of SrGO membranes could be up to 118.2 L m−2 h−1 bar−1, which is 7.6 times higher than that of GO membrane (15.5 L m−2 h−1 bar−1). Benefiting from their good electrical conductivity, the SrGO membranes could also function as an electrode and demonstrate a significantly increased rejection toward negatively charged molecules and positively charged heavy metal ions such as Cu2+, Cr3+ and Cd2+, if given an appropriate negative potential. The rejection ratios of these metal ions can be increased from <20% at 0 V to >99% at 2.0 V. This is attributed to the enhanced electrostatic repulsion between the SrGO membrane and the like-charged molecules, and the increased electrostatic adsorption and electrochemical reduction in these heavy metal ions on the membranes. This study is expected to contribute to efficient water treatment and the advance of graphene-based membranes.
Estimation of Bond Strength and Effective Bond Length for the Double Strap Joint between Carbon Fiber Reinforced Polymer (CFRP) Plate and Corroded Steel Plate
Authors: Li Anbang , Wang Hao , Li Han , Kong Deliang , Xu Shanhua
Published: August 2022

In this paper, we examine the development of the estimation models of bond strength and effective bond length for a double strap joint between carbon fiber reinforced polymer (CFRP) plate and corroded steel plate. The experimental study on the bond behavior between CFRP plate and corroded steel plate is summarized first and the analytical interfacial bond–slip model for CFRP plate externally bonded to corroded steel plate is proposed. Based on the theoretical stress analysis for the CFRP plate–corroded steel plate double-lap joint, the piecewise expressions of the interfacial shear stress and the normal peel stress of the interface between CFRP plate and corroded steel plate were established. The estimation models of the bond strength and the effective bond length for the double strap joint between the CFRP plate and the corroded steel plate were consequently developed on the basis of interfacial stress distribution equations and the stress boundary conditions. The comparison between the predicted and experimental results indicated that the proposed models could be adopted to predict the bond strength and effective bond length for the CFRP plates externally bonded to corroded steel substrates with reasonable accuracy. The proposed estimation models are expected to provide meaningful references and essential data for the reliable application of CFRP strengthening system to the performance improvement of corroded steel structures.
Barrier Effects of Cellulosic Fibers with Hybrid Coating Based on Zirconium Metal-Organic Framework
Authors: Wu Qiuyue , Lis Manuel Jose
Published: August 2022

Metal-organic frameworks (MOFs) have great potential for the development of fire barriers for flammable materials. Accordingly, zirconium-based metal-organic framework (Zr-MOF), branched polyethyleneimine (BPEI), and vinyltriethoxysilane (VTES) were deposited to produce composites assembled on cellulosic fibers to investigate their barrier effects. The structure, morphology, and thermal properties of the cellulosic fibers were characterized using FTIR spectroscopy, SEM, and TGA. Compared with the untreated cotton sample, the temperature of the maximum rate of weight loss (Tmax) of C-Zr-MOF/BPEI/VTES increased from 479 to 523.3 °C and the maximum weight loss rate (Rmax) at Tmax decreased from 37.6 to 17.2 wt%/min. At 800 °C, the pristine cotton was burned out without residues whereas the residual char content of the C-Zr-MOF/BPEI/VTES sample was 7.2355 wt%. From the vertical burning tests, the results suggested that the C-Zr-MOF/BPEI/VTES sample had better barrier effects by reducing the flame-spread speed and generating more protective char layers.
Facile Synthesis and Characterization of CeO2-Nanoparticle-Loaded Carboxymethyl Cellulose as Efficient Protective Films for Mild Steel: A Comparative Study of Experiential and Computational Findings
Authors: Gouda Mohamed , Khalaf Mai M. , Al-Shuaibi Manal A. A. , Mohamed Ibrahim M. A. , Shalabi Kamal , El-Shishtawy Reda M. , El-Lateef Hany M. Abd
Published: August 2022

Corrosion is considered to be the most severe problem facing alloys and metals, one that causes potentially dangerous industrial issues such as the deterioration of buildings and machinery, and corrosion in factory tanks and pipelines in petroleum refineries, leading to limited lifetime and weak efficacy of such systems. In this work, novel CeO2-nanoparticle-loaded carboxymethyl cellulose (CMC) was successfully prepared by using a simple method. The structural configuration of the prepared CeO2-nanoparticle-loaded CMC was investigated by FE-SEM/EDX, TEM, FT-IR, and thermal analyses. The corrosion protection proficiency of uncoated and coated mild steel with CeO2-CMC systems in 1.0 M HCl solutions was studied by EOCP-time, EIS, and PDP tools. Moreover, the relationship between the structure of coating films and their corrosion protection was confirmed by DFT calculation and MC simulation. The obtained findings from the studied methods showed that the prepared CeO2-CMC-coated films reported high corrosion resistance. The protection capacity augmented with ceria presents an increase of up to 3% to achieve 98.4%. DFT calculation and MC simulation confirmed the influence of the chemical construction of coated films on its protection capacity, which was in accordance with the experimental results.
Filling Behavior in Joining Using Pin-like Structures
Authors: Wolf Michael , Drummer Dietmar
Published: August 2022

Multi-material designs enable more efficient use of material-specific properties, which is necessary for sustainable and resource-saving production. However, multi-material polymer joints confront conventional joining methods with major challenges. Therefore, novel joining processes such as joining using pin-like structures are required. Investigations into this innovative process have provided initial findings of, for example, the design criteria of the pin-like structures depending on the material combination. For further optimization of the process, the filling behavior and the shrinkage effects occurring in pin-like joining are herein investigated. These have a decisive influence on the resulting bond quality. To identify the correlations, the joining step was carried out on the one hand using vibration welding technology with and without pre-heating of the structured-partner. On the other hand, the injection molding process was used to realize filling of the structures, as well as cooling under increased pressure. The investigations show that the shrinkage behavior clearly influences the filling degree and the bond properties of the multi-material joint. For shrinkage-intensive materials, filling and cooling under pressure is essential to achieve high mechanical bond strengths, whereas for materials with low shrinkage, the pressure during the joining step is negligible.
Zinc Oxide Nanoparticles and Their Application in Adsorption of Toxic Dye from Aqueous Solution
Authors: Al-Arjan Wafa Shamsan
Published: August 2022

Dye waste is one of the most serious types of pollution in natural water bodies, since its presence can be easily detected by the naked eye, and it is not easily biodegradable. In this study, zinc oxide nanoparticles (ZnO-NPs) were generated using a chemical reduction approach involving the zinc nitrate procedure. Fourier transform infrared (FTIR), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET), and UV-vis techniques were used to analyse the surface of ZnO-NPs. The results indicate the creation of ZnO-NPs with a surface area of 95.83 m2 g−1 and a pore volume of 0.058 cm3 g−1, as well as an average pore size of 1.22 nm. In addition, the ZnO-NPs were used as an adsorbent for the removal of Ismate violet 2R (IV2R) dye from aqueous solutions under various conditions (dye concentration, pH, contact time, temperature, and adsorbent dosage) using a batch adsorption technique. Furthermore, FTIR and SEM examinations performed before and after the adsorption process indicated that the surface functionalisation and shape of the ZnO-NP nanocomposites changed significantly. A batch adsorption analysis was used to examine the extent to which operating parameters, the equilibrium isotherm, adsorption kinetics, and thermodynamics affected the results. The results of the batch technique revealed that the best results were obtained in the treatment with 0.04 g of ZnO-NP nanoparticles at 30 °C and pH 2 with an initial dye concentration of 10 mg L−1, which removed 91.5% and 65.6% of dye from synthetic and textile industry effluents, respectively. Additionally, six adsorption isotherm models were investigated by mathematical modelling and were validated for the adsorption process, and error function equations were applied to the isotherm model results in order to find the best-fit isotherm model. Likewise, the pseudo-second-order kinetic model fit well. A thermodynamic study revealed that IV2R adsorption on ZnO-NPs is a spontaneous, endothermic, and feasible sorption process. Finally, the synthesised nanocomposites prove to be excellent candidates for IV2R removal from water and real wastewater systems.
Polymer Conductive Membrane-Based Non-Touch Mode Circular Capacitive Pressure Sensors: An Analytical Solution-Based Method for Design and Numerical Calibration
Authors: Li Fei-Yan , Zhang Qi , Li Xue , He Xiao-Ting , Sun Jun-Yi
Published: August 2022

In this paper, an analytical solution-based method for the design and numerical calibration of polymer conductive membrane-based non-touch mode circular capacitive pressure sensors is presented. The accurate analytical relationship between the capacitance and applied pressure of the sensors is derived by using the analytical solution for the elastic behavior of the circular polymer conductive membranes under pressure. Based on numerical calculations using the accurate analytical relationship and the analytical solution, the analytical relationship between the pressure as output and the capacitance as input, which is necessary to achieve the capacitive pressure sensor mechanism of detecting pressure by measuring capacitance, is accurately established by least-squares data fitting. An example of how to arrive at the design and numerical calibration of a non-touch mode circular capacitive pressure sensor is first given. Then, the influence of changing design parameters such as membrane thickness and Young’s modulus of elasticity on input–output relationships is investigated, thus clarifying the direction of approaching the desired input–output relationships by changing design parameters.
Biopolymer Textile Structure of Chitosan with Polyester
Authors: Kaurin Tea , Pušić Tanja , Čurlin Mirjana
Published: August 2022

The research deals with functionalization of a standard polyester fabric with biopolymer chitosan, whose premises are multifunctional and favour ecological effects. Due to the incompatibility of synthetic and natural polymers, the chitosan treatment was preceded by alkaline hydrolysis with sodium hydroxide with the addition of cationic and anionic surfactants as promoters. Compatibility of the chitosan with untreated and alkali-hydrolyzed fabrics was performed by analysis of mechanical and physico-chemical properties. The number of characterisation procedures performed required the use of hierarchical cluster analysis (HCA) to identify homogeneous groups or clusters in which similarities and differences between samples are visible. Almost all applied methods and evaluation parameters have shown that alkaline hydrolysis of polyester fabric has the best potential for functionalization with chitosan. Therefore, the addition of surfactants as promoters during alkaline hydrolysis is not necessary in the pretreatment process phase.
Novel Nanotechnology-Based Approaches for Targeting HIV Reservoirs
Authors: Fotooh Abadi Leila , Damiri Fouad , Zehravi Mehrukh , Joshi Rohit , Pai Rohan , Berrada Mohammed , Massoud Ehab El Sayed , Rahman Md. Habibur , Rojekar Satish , Cavalu Simona
Published: August 2022

Highly active anti-retroviral therapy (HAART) is prescribed for HIV infection and, to a certain extent, limits the infection’s spread. However, it cannot completely eradicate the latent virus in remote and cellular reservoir areas, and due to the complex nature of the infection, the total eradication of HIV is difficult to achieve. Furthermore, monotherapy and multiple therapies are not of much help. Hence, there is a dire need for novel drug delivery strategies that may improve efficacy, decrease side effects, reduce dosing frequency, and improve patient adherence to therapy. Such a novel strategy could help to target the reservoir sites and eradicate HIV from different biological sanctuaries. In the current review, we have described HIV pathogenesis, the mechanism of HIV replication, and different biological reservoir sites to better understand the underlying mechanisms of HIV spread. Further, the review deliberates on the challenges faced by the current conventional drug delivery systems and introduces some novel drug delivery strategies that have been explored to overcome conventional drug delivery limitations. In addition, the review also summarizes several nanotechnology-based approaches that are being explored to resolve the challenges of HIV treatment by the virtue of delivering a variety of anti-HIV agents, either as combination therapies or by actively targeting HIV reservoir sites.
Improvement the Flame Retardancy and Thermal Conductivity of Epoxy Composites via Melamine Polyphosphate-Modified Carbon Nanotubes
Authors: Shi Xuejun , Luo Shiying , Du Xiangxiang , Li Qingbin , Cheng Shiping
Published: August 2022

Surface chemical modification of carbon nanotubes can enhance the compatibility with polymers and improve flame retardancy performances. In this work, the double bond active sites were constructed on the surface of carbon nanotubes modified by the γ-methacryloyloxypropyl trimethoxysilane (KH570). Glycidyl methacrylate (GMA) was further grafted onto the surface of carbon nanotubes via free radical polymerization. Finally, the flame retardant melamine polyphosphate (MPP) was bonded to the surface of carbon nanotubes by the ring-opening reaction. This modification process was proved to be achieved by infrared spectroscopy and thermogravimetric test. The carbon nanotubes modified by flame retardant were added into the epoxy matrix and cured to prepare flame retardant and thermal conductive composites. The flame retardancy of composites were studied by cone calorimetry, UL94 vertical combustion test and limiting oxygen index. The thermal conductivity of composites was characterized by laser thermal conductivity instrument. The results showed that when the addition amount of flame retardant MPP-modified carbon nanotubes in composites was 10 wt%, the flame retardant level of UL94 reached to V2, the limiting oxygen index increased from 25.1 of pure epoxy resin to 28.3, the PHRR of pure epoxy resin was reduced from 800 kW/m2 to 645 kW/m2 of composites and thermal conductivity of composites was enhanced from 0.21 W/m·K−1 of pure epoxy resin to 0.42 W/m·K−1 of the composites.
Effects of Fumed Silica on Thixotropic Behavior and Processing Window by UV-Assisted Direct Ink Writing
Authors: Jiang Fengze , Zhou Mingyong , Drummer Dietmar
Published: August 2022

In this research, the effects of fumed silica (FS) on the Ultraviolet (UV)-ink rheological behavior and processing windows were discussed. Objects using different concentrations of FS inks were printed by the modified UV-Direct ink writing (DIW) printer. The function of fumed silica in the ink-based system has been verified, and the processing scope has been expended with a suitable amount of FS combined with the UV light. The results show that the combination of a suitable amount of FS with the UV-DIW system reaches fast and accurate printing with a larger processing window compared to the non-UV system. However, an excessively high concentration of FS will increase the yield stress of the ink, which also increases the requirement of extrusion unit and the die-swelling effects.
An Investigation into the Adsorption Mechanism of Organic Anions on a New Spandex
Authors: Shen Xiaoxing , Gao Pu , Jin Tingting , Ding Yi , Bao Chaoyan
Published: August 2022

In recent years, there has been significant interest in the study of spandex in high-elasticity sensors. As a new kind of special spandex, dyeable spandex shows strong adsorption capacity for anions. In this study, neutral red G was used as an anion adsorption simulator to study the adsorption mechanism of dyeable spandex on anionic materials. The structure of dyeable spandex was characterized by the modern instrumental analysis method, and the adsorption kinetics and thermodynamics of neutral red G on dyeable spandex were discussed. The results show that the use of mixed amines as chain extenders for dyeable spandex reduced the regularity of molecules and the crystallinity of spandex, which was beneficial to the diffusion adsorption of anions. On the other hand, the number of secondary amino groups increased, providing more adsorption sites under acidic conditions. The adsorption of neutral red G on dyeable spandex satisfied the quasi-second-order kinetics and the Langmuir adsorption model, indicating that dye adsorption on spandex was mainly electrostatic. The diffusion coefficient and equilibrium adsorption capacity of neutral red G on dyeable spandex increased significantly, whereas enthalpy and entropy decreased.
Metal Nanoparticles–Polymers Hybrid Materials I
Authors: Venditti Iole
Published: August 2022

Important discoveries have characterized the last decade, highlighting the importance of investment in research in fields such as medicine, biology, computer science, and physics [...]
Gum Hydrocolloids Reinforced Silver Nanoparticle Sponge for Catalytic Degradation of Water Pollutants
Authors: Ramakrishnan Rohith , Silvestri Daniele , Sumitha Nechikkottil , Nguyen Nhung , Havlíček Karel , Łukowiec Dariusz , Wacławek Stanisław , Černík Miroslav , Tiwari Diwakar , Padil Vinod , Varma Rajender
Published: August 2022

The accumulation of organic contaminants including dyes in aquatic systems is of significant environmental concern, necessitating the development of affordable and sustainable materials for the treatment/elimination of these hazardous pollutants. Here, a green synthesis strategy has been used to develop a self-assembled gum kondagogu-sodium alginate bioconjugate sponge adorned with silver nanoparticles, for the first time. The properties of the nanocomposite sponge were then analyzed using FTIR, TGA, SEM, and MicroCT. The ensued biobased sponge exhibited hierarchical microstructure, open cellular pores, good shape memory, and mechanical properties. It merges the attributes of an open cellular porous structure with metal nanoparticles and are envisaged to be deployed as a sustainable catalytic system for reducing contaminants in the aqueous environment. This nanocomposite sponge showed enhanced catalytic effectiveness (km values up to 37 min−1 g−1 and 44 min−1 g−1 for methylene blue and 4-nitrophenol, respectively), antibacterial properties, reusability, and biodegradability (65% biodegradation in 28 days).
Colour Stability of 3D-Printed and Prefabricated Denture Teeth after Immersion in Different Colouring Agents—An In Vitro Study
Authors: Dimitrova Mariya , Chuchulska Bozhana , Zlatev Stefan , Kazakova Rada
Published: August 2022

This study investigated the colour stability of three dimensional (3D)-printed and conventional denture teeth after immersion in different colourants. A total of 60 artificial maxillary central incisors were selected from three types of materials: 3D-printed dental resin (NextDent, 3D Systems, Soesterberg, The Netherlands), prefabricated acrylic teeth in Ivostar Shade (Ivoclar Vivadent, Schaan, Liechtenstein), and SpofaDent Plus in shade A2 (SpofaDental, Jičín, Czechia). These were immersed in four types of colourants at room temperature (23 °C ± 1 °C), including artificial saliva (pH = 6.8) as a control group, coffee, red wine, and Coca-Cola (n = 5). The temperature and the pH of the colouring agents were maintained throughout all immersion periods. After 7 days (T1), 14 days (T2), and 21 days (T3), the ∆E values were measured with a SpectroShade Micro (SpectroShade, Oxnard, CA, USA) spectrophotometer. Their means were then calculated and compared by two-way ANOVA. The independent factors, immersion time and different staining solutions, as well as the interaction between these factors, significantly influenced ΔE. The highest and the lowest mean ∆Es were recorded for prefabricated teeth in red wine, and 3D-printed teeth in artificial saliva, respectively. All the specimens demonstrated an increased colour change at T1 compared to T3, and the difference in mean ∆E was statistically significant.
Withdrawal Performance of Nails and Screws in Cross-Laminated Timber (CLT) Made of Poplar (Populus alba) and Fir (Abies alba)
Authors: Abdoli Farshid , Rashidi Maria , Rostampour-Haftkhani Akbar , Layeghi Mohammad , Ebrahimi Ghanbar
Published: August 2022

Cross-laminated timber (CLT) can be used as an element in various parts of timber structures, such as bridges. Fast-growing hardwood species, like poplar, are useful in regions where there is a lack of wood resources. In this study, the withdrawal resistance of nine types of conventional fasteners (stainless-steel nails, concrete nails and screws, drywall screws, three types of partially and fully threaded wood screws, and two types of lag screws), with three loading directions (parallel to the grain, perpendicular to the surface, and tangential), and two layer arrangements (0-90-0° and 0-45-0°) in 3-ply CLTs made of poplar as a fast-growing species and fir as a common species in manufacturing of CLT was investigated. Lag screws (10 mm) displayed the highest withdrawal resistance (145.77 N), whereas steel nails had the lowest (13.13 N), according to the main effect analysis. Furthermore, fasteners loaded perpendicular to the grain (perpendicular to the surface and tangential) had higher withdrawal resistance than those loaded parallel to the grain (edge). In terms of the layer arrangement, fasteners in CLTs manufactured from poplar wood (0-45-0°) had the greatest withdrawal resistance, followed by CLTs manufactured from poplar wood in the (0-90-0°) arrangement, and finally, those made from fir wood in the (0-90-0°) arrangement. The fastener type had the most significant impact on the withdrawal resistance, so changing the fastener type from nails to screws increased it by about 5–11 times, which is consistent with other studies. The results showed that poplar, a fast-growth species, is a proper wood for manufacturing CLTs in terms of fastener withdrawal performance.