bluuebunny/crossref_metadata_2025 huggingface dataset:
SLC38A5 Modulates Ferroptosis to Overcome Gemcitabine Resistance in Pancreatic Cancer
Authors: Kim Myeong Jin , Kim Hyung Sun , Kang Hyeon Woong , Lee Da Eun , Hong Woosol Chris , Kim Ju Hyun , Kim Minsoo , Cheong Jae-Ho , Kim Hyo Jung , Park Joon Seong
Published: October 2023

Pancreatic cancer is characterized by a poor prognosis, with its five-year survival rate lower than that of any other cancer type. Gemcitabine, a standard treatment for pancreatic cancer, often has poor outcomes for patients as a result of chemoresistance. Therefore, novel therapeutic targets must be identified to overcome gemcitabine resistance. Here, we found that SLC38A5, a glutamine transporter, is more highly overexpressed in gemcitabine-resistant patients than in gemcitabine-sensitive patients. Furthermore, the deletion of SLC38A5 decreased the proliferation and migration of gemcitabine-resistant PDAC cells. We also found that the inhibition of SLC38A5 triggered the ferroptosis signaling pathway via RNA sequencing. Also, silencing SLC38A5 induced mitochondrial dysfunction and reduced glutamine uptake and glutathione (GSH) levels, and downregulated the expressions of GSH-related genes NRF2 and GPX4. The blockade of glutamine uptake negatively modulated the mTOR-SREBP1-SCD1 signaling pathway. Therefore, suppression of SLC38A5 triggers ferroptosis via two pathways that regulate lipid ROS levels. Similarly, we observed that knockdown of SLC38A5 restored gemcitabine sensitivity by hindering tumor growth and metastasis in the orthotopic mouse model. Altogether, our results demonstrate that SLC38A5 could be a novel target to overcome gemcitabine resistance in PDAC therapy.
A Green Approach to Valorizing Abundant Aquatic Weeds for Nutrient-Rich Edible Paper Sheets Production in Bangladesh
Authors: Suraiya Sharmin , Bristy Suraiya Afrin , Ali Md. Sadek , Biswas Anusree , Ali Md. Rasal , Haq Monjurul
Published: October 2023

The rapid and unprecedented expansion of the global population highlights concerns about the sufficiency of food resources to sustain this growth. This study investigates and substantiates the feasibility of renewable food resources in order to meet the nutritional requirements of consumers. Three edible aquatic weeds, helencha (Enhydra fluctuans), malancha (Alternanthera philoxeroides), and kalmi (Ipomoea aquatica), were used to produce edible paper sheets. The composition of the raw aquatic weeds and paper sheet samples was analyzed, including the proximate composition, amino acid content, minerals and heavy metal contents, and bioactive compounds. The dried raw aquatic weeds and paper sheets showed similar proximate compositions, with carbohydrates being the highest component (50.38–64.63%), followed by crude protein (15.25–19.13%), ash (9.30–15.88%), and lipid (1.55–3.43%). The raw weeds and paper sheets were rich in essential minerals like Na, Ca, and Zn with contents ranging from 27.7 mg/100 g to 30.4 mg/100 g, 126.8 mg/100 g to 489.65 mg/100 g, and 4.5 mg/100 g to 16.3 mg/100 g, respectively. Acceptable levels of heavy metals, including Ni, Pb, and Cu, were found. The paper sheets contained seven essential and eight non-essential amino acids. Among the essential amino acids, the phenylalanine content was the highest at 2735.9 mg/100 g in E. fluctuans paper sheets, followed by methionine at 2377.29 mg/100 g in the raw E. fluctuans and histidine at 1972.6 mg/100 g in E. fluctuans paper sheets. A. philoxeroides sheets showed the highest total amino acid content (16,146.81 mg/100 g), while I. aquatica showed the lowest (13,118.67 mg/100 g). The aquatic weed paper sheets were rich in bioactive compounds, and the numbers in E. fluctuans, A. philoxeroides, and I. aquatica paper sheets were 31, 33, and 40, respectively. There were no significant changes in the nutritional content of the aquatic weeds in paper sheet form compared with the raw weeds, which suggests promising prospects for their production and consumption as a source of nutrition and bioactive compounds.
Serum Markers of Brain Injury in Pediatric Patients with Congenital Heart Defects Undergoing Cardiac Surgery: Diagnostic and Prognostic Role
Authors: Chiperi Lacramioara Eliza , Huţanu Adina , Tecar Cristina , Muntean Iolanda
Published: October 2023

Introduction: The objectives of this study were to assess the role of neuromarkers like glial fibrillary acidic protein (GFAP), brain-derived neurotrophic factor (BDNF), protein S100 (pS100), and neuron-specific enolase (NSE) as diagnostic markers of acute brain injury and also as prognostic markers for short-term neurodevelopmental impairment. Methods: Pediatric patients with congenital heart defects (CHDs) undergoing elective cardiac surgery were included. Neurodevelopmental functioning was assessed preoperatively and 4–6 months postoperatively using the Denver Developmental Screening Test II. Blood samples were collected preoperatively and postoperatively. During surgery, regional cerebral tissue oxygen saturation was monitored using near-infrared spectroscopy (NIRS). Results: Forty-two patients were enrolled and dichotomized into cyanotic and non-cyanotic groups based on peripheric oxygen saturation. Nineteen patients (65.5%) had abnormal developmental scores in the non-cyanotic group and eleven (84.6%) in the cyanotic group. A good diagnostic model was observed between NIRS values and GFAP in the cyanotic CHD group (AUC = 0.7). A good predicting model was observed with GFAP and developmental scores in the cyanotic CHD group (AUC = 0.667). A correlation was found between NSE and developmental quotient scores (r = 0.09, p = 0.046). Conclusions: From all four neuromarkers studied, only GFAP was demonstrated to be a good diagnostic and prognostic factor in cyanotic CHD patients. NSE had only prognostic value.
Corrosion Performance Analysis of Tubing Materials with Different Cr Contents in the CO2 Flooding Injection–Production Environment
Authors: Zhao Xuehui , Li Guoping , Liu Junlin , Li Mingxing , Du Quanqing , Han Yan
Published: October 2023

In order to clarify the difference in corrosion performance between low Cr-containing (3Cr, 5Cr, and 9Cr) tubing material and carbon steel N80 in the Carbon dioxide (CO2) flooding injection and production environment and the range of adaptation, corrosion tests and analysis were carried out in simulated working conditions. In this paper, the electrochemical potentiodynamic testing technology and the weight loss method were used to comparatively analyze the corrosion performance and variation law of three types of tubing materials with different Cr contents in a simulated CO2 flooding-produced water environment under different partial pressure conditions. Additionally, scanning electron microscopy and Energy Dispersive Spectrometer (EDS) analysis were conducted to examine the surface corrosion morphology characteristics and elemental composition of material films under various conditions. The results indicate that the open circuit potentials of 3Cr, 5Cr, and carbon steel N80 were similar under the same experimental conditions. However, the open circuit potentials of 9Cr were relatively high and there was an obvious passivation zone in anodic polarization. Nevertheless, compared to that of 13Cr, the passivation state was unstable, and pitting corrosion continued to expand once it formed. This demonstrates that the corrosion resistance of the material can be effectively enhanced and a stable passivation state can be achieved in the anodic polarization region when the Cr content of the material reaches at least 13%. The service life of materials can be predicted based on their corrosion rate under high temperature and pressure simulation environments. We found that 9Cr materials exhibited good adaptability while 3Cr and 5Cr materials showed poor adaptability. Therefore, it was not recommended to use 3Cr and 5Cr materials. Therefore, 3Cr, 5Cr, and N80 materials will be used at lower partial pressure levels of CO2 (<0.2 MPa).
The Depairing Current Density of a Fe(Se,Te) Crystal Evaluated in Presence of Demagnetizing Factors
Authors: Galluzzi Armando , Buchkov Krastyo , Tomov Vihren , Nazarova Elena , Leo Antonio , Grimaldi Gaia , Crisan Adrian , Polichetti Massimiliano
Published: October 2023

The effect of the demagnetizing factor, regarding the determination of the de-pairing current density Jdep, has been studied in the case of a Fe(Se,Te) crystal, using DC magnetic measurements as a function of a magnetic field (H) at different temperatures (T). First, the lower critical field Hc1(T) values were obtained, and the demagnetization effects acting on them were investigated after calculating the demagnetizing factor. The temperature behaviors of both the original Hc1 values and the ones obtained after considering the demagnetization effects (Hc1demag) were analyzed, and the temperature dependence of the London penetration depth λL(T) was obtained in both cases. In particular, the λL(T) curves were fitted with a power law dependence, indicating the presence of low-energy quasiparticle excitations. Furthermore, by plotting λL−2 as a function of T, we found that our sample behaves as a multigap superconductor, which is similar to other Fe-11 family iron-based compounds. After that, the coherence length ξ values were extracted, starting with the Hc2(T) curve. The knowledge of λL and ξ allowed us to determine the Jdep values and to observe how they are influenced by the demagnetizing factor.
On the Security of Quantum Key Distribution Networks
Authors: Lella Eufemia , Schmid Giovanni
Published: October 2023

The main purpose of a quantum key distribution network is to provide secret keys to any users or applications requiring a high level of security, ideally such as to offer the best protection against any computational attack, even of a quantum nature. The keys shared through a point-to-point link between a source and a detector using a quantum key distribution protocol can be proven information-theoretically secure based on the quantum information theory. However, evaluating the security of a quantum key distribution network, especially if it is based on relay nodes, goes far beyond the quantum security of its single quantum links, involving aspects of conventional security for devices and their communication channels. In this contribution, we perform a rigorous threat analysis based on the most recent recommendations and practical network deployment security issues. We show that, at least in the current state of our understanding of quantum cryptography, quantum key distribution networks can only offer computational security and that their security in practical implementations in the shorter term requires resorting to post-quantum cryptography.
An Influence of Fluorinated Alkyl Substituents on Structure and Magnetic Properties of Mn(II) Complexes with Pyrazolyl-Substituted Nitronyl Nitroxides
Authors: Kudryavtseva Ekaterina , Serykh Andrey , Ugrak Bogdan , Dutova Tatyana , Nasyrova Darina , Korlyukov Alexander , Zykin Mikhail , Efimov Nikolay , Bogomyakov Artem , Tretyakov Evgeny
Published: October 2023

New complexes of manganese(II) hexafluoroacetylacetonate [Mn(hfac)2] with 2-(1-R-3-pyrazol-4-yl)-4,4,5,5-tetramethyl-2-imidazoline-3-oxide-1-oxyl (R = CHF2, CH2CH2F, CH2CHF2 or CH2CF3) were synthesised and characterised structurally and magnetically. All complexes were prepared under similar conditions. Nonetheless, their crystal structures were considerably different. Depending on the structure of fluorinated alkyl substituent R, the complexation reaction led to complexes of three types: chain-polymeric complexes with the head-to-head or head-to-tail motif and complexes of molecular structure. All complexes show strong antiferromagnetic behaviour in a high-temperature region (150–300 K) and weak ferro- or antiferromagnetic exchange interactions at low temperatures. The stronger antiferromagnetic exchange, −101.7 ± 1.5 or −136 ± 10 cm−1, −82.3 ± 1.3 cm−1 and −87.4 ± 1.3 cm−1, was attributed to the magnetic interaction in three- or two-spin clusters: {>N∸O–Mn2+–O∸N<} or {>N∸O–Mn2+}, respectively. The weaker antiferromagnetic interaction, −0.005, between three-spin clusters or ferromagnetic interactions, 0.18–0.81 cm−1, between two-spin clusters are realised through the pyrazole ring or intermolecular contacts.
Long-Term Stability of Harvest Mouse Population
Authors: Balčiauskas Linas , Balčiauskienė Laima
Published: October 2023

The Eurasian harvest mouse (Micromys minutus) is a tiny rodent of the Palearctic and Indomalayan regions, with a distinct regional species status in Europe and irregularly varying local numbers. We analysed the population of M. minutus in Lithuania (Northern Europe) based on trapping data from 1975 to 2022 and owl pellet data from 1986 to 2009. Based on both datasets, the proportion of this species in the small mammal community was similar, 1.13% and 0.62%, respectively. The proportions have remained stable across all decades. Relative abundance was 1.19 ± 0.19 individuals per 1000 trap days, stable over the long term and across the country. Irregular fluctuations in abundance were observed in some of the sites surveyed. The highest average RA was recorded in open sedge habitats, meadows and marshes. The absolute highest RA was 88 individuals per 1000 trap days in floodplain meadows after a major flood. Although the negative impact of habitat anthropogenisation has been confirmed, M. minutus does not require special conservation measures in Lithuania.
Diabetes Mellitus—Digital Solutions to Improve Medication Adherence: Scoping Review
Authors: Georgieva Nikol , Tenev Viktor , Kamusheva Maria , Petrova Guenka
Published: October 2023

Medication adherence (MA) is a major problem. On average 50% of chronic disease management medications are not taken as prescribed While digital healthcare tools like mobile apps offer benefits such as informative messages and prescription management, they must be personalized and offer support across all medication phases to effectively address individual patient factors and optimize adherence, with room for further improvements. This scoping review examined the impact of digital health technologies on MA in adults with diabetes as well as their benefits and barriers. Using PubMed and Scopus databases, 11 out of 385 studies (2.86%) from January 2017 to August 2023 met the criteria for digital health interventions in diabetes MA, assessed through the Chronic Care Model. The Chronic Care Model (CCM) is a patient-centered, evidence-based framework designed to improve the care and outcomes for chronic illness patients, consisting of six core elements and enhanced by eHealth tools that facilitate self-management and support through digital innovations. The results demonstrate the effectiveness of digital health technology in improving medication adherence among adults with diabetes. Specific digital interventions, including mobile apps like Gather and Medisafe, SMS text messaging, telemonitoring, and tailored care management have demonstrated effectiveness in enhancing MA. These interventions have shown positive outcomes, including enhanced glycemic control and increased patient engagement. Some of the limitations, which these technologies face, are the poor usability, digital illiteracy among the patients, low rates of sustainability and low accessibility among the elderly population. Digital health technology shows promise in enhancing medication adherence among adults with diabetes, as revealed in this scoping review. However, ongoing research is necessary to fine-tune these interventions for improved outcomes and the overall well-being of individuals with diabetes. Additional improvement of the technologies and adaptation to the diverse population might be a good field for exploration.
Recombinant TBEV Protein E of the Siberian Subtype Is a Candidate Antigen in the ELISA Test System for Differential Diagnosis
Authors: Baryshnikova Victoria , Turchenko Yuriy , Tuchynskaya Ksenia , Belyaletdinova Ilmira , Butenko Alexander , Dereventsova Alena , Ignatiev Georgy , Kholodilov Ivan , Larichev Victor , Lyapeykova Ekaterina , Rogova Anastasiya , Shakaryan Armen , Shishova Anna , Gmyl Anatoly , Karganova Galina
Published: October 2023

The tick-borne encephalitis virus (TBEV) is one of the most common members of the Orthoflavivirus genus, which comprises the causative agents of severe diseases in humans and animals. Due to the expanding areas of orthoflavivirus infection, its differential diagnosis is highly demanded. Commercial test kits based on inactivated TBEV may not provide reliable differentiation between flaviviruses because of serological crossover in this genus. Application of recombinant domains (sE and dIII) of the TBEV Sukhar-strain protein E as antigens in an ELISA test system allowed us to identify a wide range of antibodies specific to different TBEV strains. We tested 53 sera from human patients with confirmed TBE diagnosis (the efficacy of our test system based on sE protein was 98%) and 56 sera from patients with other orthoflavivirus infections in which no positive ones were detected using our ELISA test system, thus being indicative of its 100% specificity. We also tested mouse and rabbit sera containing antibodies specific to 17 TBEV strains belonging to different subtypes; this assay exhibited high efficacy and differentiation ability in detecting antibodies against TBEV from other orthoflaviviruses such as Omsk hemorrhagic fever, Powassan, yellow fever, dengue, West Nile, Zika, and Japanese encephalitis viruses.
Prevalence of the Bifid Mandibular Condyle and Its Relationship with Pathologies of the Temporomandibular Joint: A Systematic Review and Meta-Analysis
Authors: Valenzuela-Fuenzalida Juan José , Navarro Kora-lle Keller , Urbina Pia , Trujillo-Riveros Martin , Nova-Baeza Pablo , Orellana-Donoso Mathias , Rodriguez-Luengo Macarena , Beccerra Farfan Alvaro , Sanchis-Gimeno Juan A.
Published: October 2023

Objective: The aim of this study was to describe the prevalence of anatomical variants in the bifid mandibular condyle (BMC) and report its association with temporomandibular joint (TMJ) pathology. Methods: We searched the Medline, Scopus, Web of Science, Google Scholar, CINAHL, and LILACS databases from their inception up to September 2023. Two authors independently performed the search, study selection, and data extraction, and they also assessed the methodological quality with an assurance tool for anatomical studies (AQUA). Finally, the pooled prevalence was estimated using a random effects model. Results: A total of 50 studies met the eligibility criteria. Twenty studies, with a total of 88,625 subjects, were included in the meta-analysis. The overall prevalence of the bifid mandibular condyle (BMC) variant was 1% (95% CI = 1% to 2%). Conclusions: The correlation between the BMC and TMJ pathologies has a relatively low prevalence in studies that present a considerable number of subjects. From a clinical point of view, a direct association cannot be made between the presence of the BMC and TMJ pathologies or symptoms.
Characterization of New Alpha Zero (α0) Thalassaemia Deletion (−−GB) among Malays in Malaysian Population
Authors: Yasin Norafiza Mohd , Abdul Hamid Faidatul Syazlin , Hassan Syahzuwan , Mat Yusoff Yuslina , Mohd Sahid Ermi Neiza , Esa Ezalia
Published: October 2023

Malaysia is a multicultural and multiethnic country comprising numerous ethnic groups. From the total population of 32.7 million, Malays form the bulk of the Bumiputera in Malaysia comprise about 69.9%, followed by Chinese 22.8%, Indian 6.6%, and others 0.7%. The heterogeneous population and increasing numbers of non-citizens in this country affects the heterogeneity of genetic diseases, diversity, and heterogeneity of thalassaemia mutations. Alpha (α)-thalassaemia is an inherited haemoglobin disorder characterized by hypochromic microcytic anaemia caused by a quantitative reduction in the α-globin chain. A majority of the α-thalassaemia are caused by deletions in the α-globin gene cluster. Among Malays, the most common deletional alpha thalassaemia is −α3.7 deletion followed by −−SEA deletion. We described the molecular characterization of a new −−GB deletion in our population, involving both alpha genes in cis. Interestingly, we found that this mutation is unique among Malay ethnicities. It is important to diagnose this deletion because of the 25% risk of Hb Bart’s with hydrops fetalis in the offspring when in combination with another α0- thalassaemia allele. MLPA is a suitable method to detect unknown and uncommon deletions and to characterize those cases which remain unresolved after a standard diagnostic approach.
Alveolar Ridge Preservation with Autologous Platelet-Rich Fibrin (PRF): Case Reports and the Rationale
Authors: Ucer Cemal , Khan Rabia S.
Published: October 2023

In dental implantology, alveolar ridge preservation (ARP) has emerged as a standard technique to address dimensional changes that affect alveolar ridge morphology following tooth loss. Various alternative graft materials, including xenografts, alloplasts, and allografts, have been effectively employed in fresh extraction sites for ARP. Current evidence suggests that these materials primarily serve as bio-scaffolds, which are slowly incorporated, thus necessitating a waiting period of at least 4–6 months before implant placement. Consequently, the ARP technique extends the overall duration of implant treatment by several months. Recently, the incorporation of a form of autologous platelet concentrate, known as platelet-rich fibrin (PRF), has been advocated in conjunction with ARP as a method of bioenhancement of soft- and hard-tissue healing and regeneration. PRF contains platelet-derived growth factors, hormones, and bioactive components like cytokines that have demonstrated the ability to stimulate angiogenesis and tissue regeneration throughout all phases of wound healing. Additionally, the concentration of leukocytes present in the PRF matrix plays a vital role in tissue healing and regeneration as part of the osteoimmune response. The reported advantages of incorporating autogenous PRF platelet concentrates during ARP encompass reduced healing time, improved angiogenesis and bone regeneration, socket sealing through the fibrin matrix, antibacterial properties, and decreased post-extraction pain and infection risk. Therefore, the objective of this paper is to review the existing evidence regarding the application of PRF in alveolar ridge preservation (ARP) following tooth extraction. Two clinical case studies are presented, wherein ARP was enhanced with PRF, followed by implant placement within a relatively short period of 8 weeks. These cases serve as further proof of concept for supporting the adjuvant use of PRF to enhance healing and accelerate implant placement after ARP.
Research on the Method of Hypergraph Construction of Information Systems Based on Set Pair Distance Measurement
Authors: Wang Jing , Lan Siwu , Li Xiangyu , Lu Meng , Guo Jingfeng , Zhang Chunying , Liu Bin
Published: October 2023

As a kind of special graph of structured data, a hypergraph can intuitively describe not only the higher-order relation and complex connection mode between nodes but also the implicit relation between nodes. Aiming at the limitation of traditional distance measurement in high-dimensional data, a new method of hypergraph construction based on set pair theory is proposed in this paper. By means of dividing the relationship between data attributes, the set pair connection degree between samples is calculated, and the set pair distance between samples is obtained. Then, on the basis of set pair distance, the combination technique of k-nearest neighbor and ε radius is used to construct a hypergraph, and high-dimensional expression and hypergraph clustering are demonstrated experimentally. By performing experiments on different datasets on the Kaggle open-source dataset platform, the comparison of cluster purity, the Rand coefficient, and normalized mutual information are shown to demonstrate that this distance measurement method is more effective in high-dimensional expression and exhibits a more significant performance improvement in spectral clustering.
A Novel Complex-Valued Hybrid Neural Network for Automatic Modulation Classification
Authors: Xu Zhaojing , Hou Shunhu , Fang Shengliang , Hu Huachao , Ma Zhao
Published: October 2023

Currently, dealing directly with in-phase and quadrature time series data using the deep learning method is widely used in signal modulation classification. However, there is a relative lack of methods that consider the complex properties of signals. Therefore, to make full use of the inherent relationship between in-phase and quadrature time series data, a complex-valued hybrid neural network (CV-PET-CSGDNN) based on the existing PET-CGDNN network is proposed in this paper, which consists of phase parameter estimation, parameter transformation, and complex-valued signal feature extraction layers. The complex-valued signal feature extraction layers are composed of complex-valued convolutional neural networks (CNN), complex-valued gate recurrent units (GRU), squeeze-and-excite (SE) blocks, and complex-valued dense neural networks (DNN). The proposed network can improve the extraction of the intrinsic relationship between in-phase and quadrature time series data with low capacity and then improve the accuracy of modulation classification. Experiments are carried out on RML2016.10a and RML2018.01a. The results show that, compared with ResNet, CLDNN, MCLDNN, PET-CGDNN, and CV-ResNet models, our proposed complex-valued neural network (CVNN) achieves the highest average accuracy of 61.50% and 62.92% for automatic modulation classification, respectively. In addition, the proposed CV-PET-CSGDNN has a significant improvement in the misjudgment situation between 64QAM, 128QAM, and 256QAM compared with PET-CGDNN on RML2018.01a.
Heat Production Performance from an Enhanced Geothermal System (EGS) Using CO2 as the Working Fluid
Authors: Zhao Wentao , Yuan Yilong , Jing Tieya , Zhong Chenghao , Wei Shoucheng , Yin Yulong , Zhao Deyuan , Yuan Haowei , Zheng Jin , Wang Shaomin
Published: October 2023

CO2-based enhanced geothermal systems (CO2-EGS) are greatly attractive in geothermal energy production due to their high flow rates and the additional benefit of CO2 geological storage. In this work, a CO2-EGS model is built based on the available geological data in the Gonghe Basin, Northwest China. In our model, the wellbore flow is considered and coupled with a geothermal reservoir to better simulate the complex CO2 flow and heat production behavior. Based on the fractured geothermal reservoir at depths between 2900 m and 3300 m, the long-term (30-year) heat production performance is predicted using CO2 as the working fluid with fixed wellhead pressure. The results indicate that the proposed CO2-EGS will obtain an ascending heat extraction rate in the first 9 years, followed by a slight decrease in the following 21 years. Due to the significant natural convection of CO2 (e.g., low viscosity and density) in the geothermal reservoir, the mass production rate of the CO2-EGS will reach 150 kg/s. The heat extraction rates will be greater than 32 MW throughout the 30-year production period, showing a significant production performance. However, the Joule–Thomson effect in the wellbore will result in a drastic decrease in production temperature (e.g., a 62.6 °C decrease in the production well). This means that the pre-optimization analyses and physical material treatments are required during geothermal production using CO2 as the working fluid.
Impacts of Pore Structure on the Occurrence of Free Oil in Lacustrine Shale Pore Networks
Authors: You Fuliang , Liu Guangdi , Sun Mingliang , An Cheng , Li Chaozheng , Li Yishu
Published: October 2023

The ultimate recovery of shale oil is mostly dependent upon the occurrence and content of free oil within the nano-scaled pore network of shale reservoirs. Due to the nanoporous nature of shale, quantitatively characterizing the occurrence and content of free oil in shale is a formidable undertaking. To tackle this challenge, 12 lacustrine shale samples with diverse organic matter content from the Chang7 Member in the southern Ordos Basin were selected, and the characteristics of free oil occurrence were indirectly characterized by comparing changes in pore structure before and after organic solvent extraction. The free oil enrichment in shale was assessed using the oil saturation index (OSI), corrected oil saturation index (OSIcorr), and percentage of saturated hydrocarbons. The results revealed that slit-like interparticle pores with diameters less than 30 nm are dominant in the Chang7 shale. Conceptual models for the pore structures containing free oil were established for shale with total organic carbon (TOC) content less than 9% and greater than 9%, respectively. Shale samples with TOC content less than 9% exhibit a well-developed pore network characterized by relatively larger pore volume, surface area, and heterogeneity. Conversely, shale samples with TOC content exceeding 9% display a less developed pore network characterized by relatively smaller pore volume, surface area, and heterogeneity. Larger pore volume and lower organic matter abundance favor the enrichment of free oil within the lacustrine shale pore network. This study may have significant implications for understanding oil transport in shales.
Explainable Approaches for Forecasting Building Electricity Consumption
Authors: Sakkas Nikos , Yfanti Sofia , Shah Pooja , Sakkas Nikitas , Chaniotakis Christina , Daskalakis Costas , Barbu Eduard , Domnich Marharyta
Published: October 2023

Building electric energy is characterized by a significant increase in its uses (e.g., vehicle charging), a rapidly declining cost of all related data collection, and a proliferation of smart grid concepts, including diverse and flexible electricity pricing schemes. Not surprisingly, an increased number of approaches have been proposed for its modeling and forecasting. In this work, we place our emphasis on three forecasting-related issues. First, we look at the forecasting explainability, that is, the ability to understand and explain to the user what shapes the forecast. To this extent, we rely on concepts and approaches that are inherently explainable, such as the evolutionary approach of genetic programming (GP) and its associated symbolic expressions, as well as the so-called SHAP (SHapley Additive eXplanations) values, which is a well-established model agnostic approach for explainability, especially in terms of feature importance. Second, we investigate the impact of the training timeframe on the forecasting accuracy; this is driven by the realization that fast training would allow for faster deployment of forecasting in real-life solutions. And third, we explore the concept of counterfactual analysis on actionable features, that is, features that the user can really act upon and which therefore present an inherent advantage when it comes to decision support. We have found that SHAP values can provide important insights into the model explainability. In our analysis, GP models demonstrated superior performance compared to neural network-based models (with a 20–30% reduction in Root Mean Square Error (RMSE)) and time series models (with a 20–40% lower RMSE), but a rather questionable potential to produce crisp and insightful symbolic expressions, allowing a better insight into the model performance. We have also found and reported here on an important potential, especially for practical, decision support, of counterfactuals built on actionable features, and short training timeframes.
Future Challenges of the Electric Vehicle Market Perceived by Individual Drivers from Eastern Poland
Authors: Stoma Monika , Dudziak Agnieszka
Published: October 2023

In the past few years, it can be seen that the automotive market has been developing quite rapidly, especially when it comes to electric cars. This is because the development of sustainable cars seems to be an extremely important issue at the moment. Nowadays, cars with different propulsion systems (among others electric, hybrid, gas, or hydrogen) can be met on the roads. But, political action is mainly aimed at electric cars. Such an approach will certainly lead to fundamental changes in production processes in the near future via the emergence and development of new technologies in the field of electric passenger cars. Therefore, the manuscript discusses the concept of vehicles with different types of power supply, with the main emphasis on electric vehicles. The essence of electric vehicles, their genesis, rationale for development, and growth are indicated. The different markets around the world, through the prism of, on the one hand, programs supporting the purchase and use of this type of vehicle and, on the other hand, factors limiting and inhibiting their uptake, are also discussed. The research was conducted in a group of both current and potential drivers from Eastern Poland, with different categories of grouping variables used in the analyses. On the basis of the research carried out and the results obtained, it can be argued that due to various factors, the respondents’ opinions are varied, and there are no unambiguous conclusions stating that such solutions will soon be available. Indeed, a number of doubts and barriers were noted among respondents. Driver preferences are therefore a key issue, but production capacity and the profitability of investments in the purchase of vehicles with an electric power supply should also be taken into account.
A New Advance on the Improvement of Forest Ecosystem Functions in the Karst Desertification Control
Authors: Xiong Kangning , He Cheng , Zhang Mingsheng , Pu Junbing
Published: October 2023

In recent years, after the implementation of large-scale ecological restoration projects, karst areas in the South China Karst have become global “greening” hot spots. However, the biodiversity, ecosystem quality, and security patterns in karst areas are still severely affected. The reason for this is that despite the execution of karst desertification control projects, the lag mechanism of forest ecosystem functions and services is still unclear. Therefore, we analyze the progress in the research related to desertification control and the improvement of regional forest ecosystem function through a systematic literature review approach. The results show that the major landmarks achieved so far include the following aspects: based on the karst desertification control area, we have elucidated the driving factors of forest ecosystem change, discovered the ecological security pattern of landscape optimization and reconstruction, revealed the internal mechanism of forest system structure optimization and stability enhancement, overcome the technical constraints of forest water–fertilizer coupling, introduced a strategy for regulating functional traits to improve the growth and development of vegetation, proposed strategies to enhance carbon sequestration in forests and the efficiency of microbial carbon use, and created models and paths to realize the value of forest products. The key scientific issues to be addressed in the future mainly comprise the following: the effects of spatial heterogeneity on forest ecosystems, disturbances in landscape reconfiguration caused by human activities, the work mechanisms of the combination and configuration of the niche in structural optimization, the response of species configuration to the water cycle, the coupled relationship between biodiversity and soil properties, the screening and construction of the plant germplasm resource base, the functional trade-offs/synergistic mechanisms of karst forest ecosystems, the creation of policies for forest product in terms of rights, trading, and compensation, and systematic research on the extended industrial chain of forest ecosystems, its service potential, and so on.
Kinetic Analysis of Thermal Decomposition of Polyvinyl Chloride at Various Oxygen Concentrations
Authors: Yang Shuo , Wang Yong , Man Pengrui
Published: October 2023

PVC plastic products are common combustible substances seen in fires, but their thermal degradation behavior under different oxygen concentrations has not been adequately studied. The thermal degradation behavior of PVC materials in atmospheres with different oxygen concentrations was analyzed via thermogravimetric–Fourier transform infrared spectroscopy (TG-FTIR). The TG results show that the thermal degradation process of PVC under a non-oxygenated atmosphere occurred in two stages, and the activation energies of the two stages were 130–175 KJ mol−1 and 230–320 KJ mol−1, respectively; under the oxygenated atmosphere, the thermal degradation process occurred in three stages. The activation energies of the three stages were 130–175 KJ mol−1, 145–510 KJ mol−1 and 75–190 KJ mol−1, respectively. And the reaction mechanism of the second stage of thermal degradation was changed from D-ZLT3 to En by the higher oxygen concentration. Infrared spectroscopy (FTIR) was used to analyze the pyrolysis process of PVC in the non-oxygenated atmosphere, and the eight major components were as follows, in descending order according to amount released: C-H stretching > HCl > C-Cl stretching > H2O > CO2 > C-H bending > C-H aliphatic bending > CH2. For the reaction of PVC at an oxygen concentration of 7%, the nine major components, in descending order according to amount released, were as follows: CO2 > HCl > H2O > CO > C-H stretching > C-Cl stretching > C-H aliphatic bending > C-H bending > CH2. For PVC reactions at oxygen concentrations of 14% and 21%, the five major components, in descending order according to amount released, were CO2 > HCl > CO > C-Cl stretching > H2O.
Phylogeographic Analyses of the Shortfin Mako, Isurus oxyrinchus Rafinesque, 1810 (Chondrichthyes: Lamniformes) from the Central Mediterranean Sea, a Critically Endangered Species in the Region
Authors: Vella Noel , Vella Adriana
Published: October 2023

The Shortfin mako shark, Isurus oxyrinchus Rafinesque, 1810, is a globally distributed highly migratory pelagic shark species, occurring mostly in temperate and tropical regions, including the Mediterranean Sea where it is by-caught during fishing activities targeting other economically important fish species. The aim of this study is to investigate the genetic connectivity of the Shortfin mako from the central Mediterranean Sea to previously studied populations. The mtDNA control region (CR), 977 bp, of 37 I. oxyrinchus specimens collected between 2004 and 2012 from landings in Malta were analysed, and we identified nine haplotypes, including three newly discovered haplotypes that may be unique to the Mediterranean Sea and which represent 16.7% of the studied individuals. These haplotypes, together with variations in haplotype frequencies, led to significant FST and ϕST values between the Mediterranean population and other global populations, with the exception of that from the north Atlantic Ocean. This study provides the first insight of the mtDNA CR diversity of this critically endangered species in the Mediterranean Sea and highlights the importance of conserving this species in the region.
Review of Interpreting Gaseous Pollution Data Regarding Heritage Objects
Authors: Thickett David , Grøntoft Terje
Published: October 2023

Pollutant gases pose a significant risk to some cultural heritage objects, and surveys have shown that the professionals involved consider themselves to lack knowledge to fully assess risk. Three approaches towards risk assessment, research results, standards and damage functions have been considered. An assessment tool has been developed, collating over 4000 research reports into a scheme for the impact on 22 materials of acetic and formic acids, nitrogen dioxide, ozone and reduced sulphur gases. The application of doses or concentrations has been considered, the impact of measurement time compared to annual exposure investigated and a simple tool derived.
Are Sexual Assaults Related to Functional Somatic Disorders? A Cross-Sectional Study
Authors: Jacobsen Sofie Abildgaard , Frostholm Lisbeth , Buhmann Cæcilie Böck , Petersen Marie Weinreich , Ørnbøl Eva , Dantoft Thomas Meinertz , Bjerregaard Anne Ahrendt , Eplov Lene Falgaard , Carstensen Tina Birgitte Wisbech
Published: October 2023

An increasing number of sexual assaults (SAs) are being reported. This study investigated associations between SA and FSD, conceptualized as bodily distress syndrome (BDS), and five functional somatic syndromes (FSSs): chronic widespread pain (CWP), irritable bowel (IB), chronic fatigue (CF), multiple chemical sensitivity (MCS), and whiplash-associated disorder (WAD). Participants (n = 7493) from the population-based cohort Danish Study of Functional Disorders (DanFunD) completed questionnaires on FSD, emotional distress, SA, and sociodemographics. Risk ratios (RRs) for each FSD and emotional distress were calculated in nine models with SA as the primary exposure using generalized linear models with binomial family and log link and were adjusted for other potential risk factors. The results showed that SA was associated with single-organ FSD (RR = 1.51; 95% CI = 1.22–1.87), multi-organ FSD (RR = 3.51; 95% CI = 1.89–6.49), CWP (RR = 1.28; 95% CI = 0.83–1.98), IB (RR = 2.00; 95% CI = 1.30–3.07), CF (RR = 1.81; 95% CI = 1.42–2.32), WAD (RR = 2.62; 95% CI = 1.37–5.03), MCS (RR = 3.04; 95% CI = 1.79–5.17), emotional distress (RR = 1.75; 95% CI = 1.21–2.54), and health anxiety (RR = 1.65; 95% CI = 1.10–2.46). Overall, SA victims experienced significantly more somatic symptoms than individuals not exposed to SA. Adjusting for physical and emotional abuse did not change the observed associations. Our results suggest a large impact of SA on the overall somatic and mental health of SA victims. Due to the cross-sectional study design, further studies are required.
A Systematic Review of Wheelchair and Mobility Scooter Containment Systems Used Internationally on Public Transit Buses
Authors: Unsworth Carolyn A. , Timmer Amanda J.
Published: October 2023

Despite the daily need for people to travel on public transit buses using their wheeled mobility devices, relatively little information is available regarding the most efficacious, affordable, and independent approaches to assist passengers with keeping their mobility devices in the designated wheelchair access space. A systematic review was undertaken to summarize this literature, place it within a geographical and temporal context, appraise its quality, and establish common themes. Key academic and grey literature transportation databases and government websites searched from 1990 to May 2022 identified 33 documents, which were appraised using the Mixed Methods Appraisal Tool (MMAT) or the Authority, Accuracy, Coverage, Objectivity, Date, Significance (AACODS) tool. Overall, the documents included were of good quality. The literature retrieved focused on the development and testing of the active containment systems favored for use in North America with a contrastingly small examination of the effectiveness of passive or semi-passive containment systems. Almost no literature was retrieved in English from European researchers documenting the use or effectiveness of rearward-facing passive systems. While tip or slide events are relatively rare among mobility device users, the effective use of containment systems is vital to minimize these. Further research is required to support transport policy makers, operators, and bus drivers to identify and correctly implement optimal containment systems to promote safety for all passengers on public buses.
Implementation of US Post-Acute Care Payment Reform and COVID-19 Policies: Examining Experiences of Health System Leaders, Staff, Patients, and Family Caregivers—A Protocol
Authors: Leland Natalie E. , Rouch Stephanie A. , Prusynski Rachel A. , Shore Amanda D. , Kaufman Hannah , Hoover Lorelei P. , Mroz Tracy M. , Freburger Janet K. , Saliba Debra
Published: October 2023

In fiscal year 2020, new national Medicare payment models were implemented in the two most common post-acute care settings (i.e., skilled nursing facilities (SNFs) and home health agencies (HHAs)), which were followed by the emergence of COVID-19. Given concerns about the unintended consequence of these events, this study protocol will examine how organizations responded to these policies and whether there were changes in SNF and HHA access, care delivery, and outcomes from the perspectives of leadership, staff, patients, and families. We will conduct a two-phase multiple case study guided by the Institute of Medicine’s Model of Healthcare Systems. Phase I will include three cases for each setting and a maximum of fifty administrators per case. Phase II will include a subset of Phase I organizations, which are grouped into three setting-specific cases. Each Phase II case will include a maximum of four organizations. Semi-structured interviews will explore the perspectives of frontline staff, patients, and family caregivers (Phase II). Thematic analysis will be used to examine the impact of payment policy and COVID-19 on organizational operations, care delivery, and patient outcomes. The results of this study intend to develop evidence addressing concerns about the unintended consequences of the PAC payment policy during the COVID-19 pandemic.
Knowledge, Perception and Consumption of Indigenous Foods in Gauteng Region, South Africa
Authors: Kesa Hema , Tchuenchieu Kamgain Alex D. , Kwazi Zuma Mthokozisi , Mbhenyane Xikombiso
Published: October 2023

Urbanisation in South Africa has led to a nutritional transition from traditional diets (mainly based on indigenous foods) to a Western diet. Currently, the country is one of the most concerned about the prevalence of associated malnutrition and non-communicable diseases. One should, therefore, question the position of indigenous foods (IFs) in the population’s eating habits since their nutritional and health value is known. This study aimed to collect updated data on South Africans’ true awareness and consumption of indigenous foods, especially in the Gauteng region (the most urbanised province of the country). A quantitative cross-sectional research survey was conducted (n = 746). Among a list of 18 IFs, grain sorghum 32.4% (n = 242), marula 32% (n = 239), pearl millet 21.7% (n = 162), amadumbe 19.3% (n = 144) and cowpea 18.6% (n = 139) were the best known. However, the study noticed a maximum consumption of 19.3% (grain sorghum). Overall, this consumption was seasonal, and its level was significantly defined by race (p < 0.05). Black people consume more IFs compared to coloured people, Indian people and white people. Participants mostly consumed these foods for nutritional and health reasons and pointed out the problem of availability. “Poor image” was rated the lowest by all races (black 5.8%, coloured 4.2%, Indian 7.0% and white 4.1%) regarding the reasons for no or low consumption of IFs. Whatever the race, the desire to increase IF consumption was positive. The promotion of their integration into South African diets should, therefore, be considered as an intervention strategy.