bluuebunny/crossref_metadata_2025 huggingface dataset:
Polymorphic Variants of the ADAMTS5 Gene as New Markers of Joint Hypermobility
Authors: Akhiiarova K. E. , Khusainova R. I. , Yalaev B. I. , Tyurin A. V.
Published: February 2023

Joint hypermobility (JH) is a common phenotype that can be both an independent clinical syndrome and a manifestation of connective tissue diseases. The pathogenesis of JH is not well understood. JH may be a predisposing factor in the development of musculoskeletal system pathology, so it is necessary to identify its molecular markers to prevent the formation of associated disorders.Objective: to search for associations of five polymorphic variants of the ADAMTS5 gene with JH and connective tissue dysplasia (CTD).Material and methods. A one-stage screening study of young people (n=181, mean age 21.86±0.22 years) was performed. We searched for associations of polymorphic variants of the rs226794, rs9978597, rs2830585, rs229077, rs229069 loci of the ADAMTS5 gene with JH, undifferentiated CTD, and their combinations. JH was determined by the Beighton scale, CTD – by a quantitative method. The study of polymorphic variants was carried out using real-time polymerase chain reaction. To compare qualitative features, Fisher's exact test with Yates’s correction for 2×2 contingency tables was used. The strength of associations was assessed using the odds ratio (OR), differences were considered significant at p<0.05, the correction for multiple comparisons was performed using the Benjamini–Hochberg method (false discovery rate, FDR).Results and discussion. JH was detected in 128 (70.7%), signs of CTD – in 129 (71.3%) patients, including 115 (63.5%) patients in combination with JH. We found associations of the T allele and the TT genotype of the rs9978597 locus with the presence of JH (OR 5.00 and 7.81, respectively), CTD (OR 3.13 and 3.96), or their combinations (OR 6.33 and 10.23). An association of the GG genotype of the rs226794 locus with isolated JH was also found (OR 3.87).Conclusion. The GG genotype of the rs226794 locus of the ADAMTS5 gene is a marker of isolated JH, the T allele of the rs9978597 locus is a marker of both isolated JH and CTD, and their combination.
Recurrent polychondritis: a review of the literature and a clinical case description
Authors: Denisov L. N. , Vinogradova I. B. , Bakhtina L. A.
Published: February 2023

Relapsing polychondritis (RPC) is a rare disease, its diagnosis presents certain difficulties. This is due to the absence of characteristic clinical manifestations at the initial stages of the disease, late diagnosis and difficulties in selecting adequate therapy.The article presents a review of the literature on the diagnosis and treatment of RPC, as well as a clinical case with tracheobronchial tree and other organ systems involvement in the absence of classical auricular involvement.
Low molecular weight hyaluronates: biological action, efficacy, safety and clinical experience in the treatment of musculoskeletal pain syndromes (literature review and clinical observations)
Authors: Strakhov M. A. , Alekseeva L. I. , Maremkulov K. K.
Published: February 2023

Hyaluronic acid (HA) drugs are ingrained in complex treatment of osteoarthritis (OA). They have not only lubricant, but also anti-inflammatory properties, and ability to slow down the progression of OA. The article summarizes current data on the efficacy and safety of low molecular weight HA. The possibilities of using it both intra-articularly (i/a) and for the treatment of tendinopathies are considered. The authors present their own clinical experience in the treatment of patients with musculoskeletal (MS) pain syndromes.It has been shown that i/a administration of HA can effectively reduce the intensity of pain and improve joint function, and when injected into the synovial sheaths of tendons, it can also relieve pain of extra-articular localization. The peculiarities of the surgical technique, preparing for manipulation and post-injection period management are described.The existing evidence base indicates the expediency of active use of HA drugs not only for OA treatment, but also for various extra-articular musculoskeletal pain syndromes.
Empatía subjetiva como vínculo antropológico entre experiencia y verdad de fe
Authors: Cabiedas Tejero Juan Manuel
Published: February 2023

La existencia cristiana se enfrenta permanentemente al reto de fortalecer el vínculo afectivo entre experiencia de fe y verdad de fe. Este estudio trata de afrontar este desafío mediante un diálogo entre esa peculiar fuerza cognitiva humana que es la empatía y la constatación de que es precisamente éste el tipo de epistemología que reclama la hermenéutica con que el Evangelio actualiza el significado y trascendencia salvífica de la Persona de Cristo (muerto y resucitado) para el testigo de todo tiempo que se encuentra con Él.
TANGGUNG JAWAB PLATFORM MARKETPLACE TERHADAP PENJUALAN PONSEL (MOBILE PHONE) ILEGAL BERDASARKAN HUKUM NASIONAL
Authors: Jasmine Alifia , Amalia Prita , Muchtar Helitha Novianty
Published: February 2023

Perkembangan teknologi telah mempengaruhi berbagai aspek. Salah satunya adalah berkembangnya kegiatan perdagangan yang dilakukan melalui sistem elektronik (e-commerce). Meskipun keberadaan e-commerce memberikan berbagai keuntungan dalam dunia perdagangan, namun e-commerce memiliki berbagai permasalahan seperti penjualan barang ilegal yang terjadi dalam platform marketplace, salah satu bentuk e-commerce. Salah satu barang ilegal yang marak beredar tersebut adalah ponsel (mobile phone). Berdasarkan hal tersebut, tulisan ini akan mengangkat permasalahan mengenai pengaturan hukum serta tanggung jawab platform marketplace dalam hal terjadinya penjualan ponsel ilegal. Dengan metode yuridis normatif, penulis melakukan analisis terhadap peraturan perundang-undangan, peraturan kebijakan, teori-teori terkait cyberspace, asas-asas penyelenggaraan e-commerce, serta prinsip pertanggungjawaban, yang mana menunjukkan platform marketplace sebagai penyelenggara sistem elektronik memiliki tanggung jawab hukum dalam hal adanya penjualan ponsel ilegal.
BANKACILIK SEKTÖRÜNDE KREDİ RİSK YÖNETİMİ VE BİR TAHMİN MODELİ ÖRNEĞİ
Authors: DUMAN Selim , YILMAZ TÜRKMEN Sibel
Published: February 2023

Ekonomik hayatın en önemli aktörlerinden olan firmalar için finansman kaynaklarının etkin şekilde yönetilmesi

önem arz etmektedir. Finansman yapılarının niteliği bu yönetimin başarısına etki ederken, firmalar içsel

ya da dışsal bazı nedenlerle sıklıkla finansman açıklarıyla karşılaşabilmektedirler. Firmaların finansman sağlayıcılarının

başında gelen bankalar ise, ekonomik faaliyetlerin yürütülmesi için üstlendikleri bu görev doğrultusunda

ülke ekonomilerinin büyüme ve kalkınmasında aktif rol oynamaktadırlar. Ancak bankaların üstlendikleri

bu görevle aynı doğrultuda maruz kaldıkları riskler de artmakta ve performanslarını korumaları için başarılı

bir risk yönetimi de zorunlu hale gelmektedir. Bankaların yönetmek zorunda oldukları riskleri çeşitlendirmek

mümkünken, bu risklerin en temel olanı ana ürünleri olan kredinin geri ödenmemesinden kaynaklanan risktir.

Banka portföyleri içinde firma kredilerinin önemli bir paya sahip olduğu dikkate alındığında, firma performanslarının

değerlendirilmesi bankaların alacakları önlemlerin başında gelmektedir. Bu çerçevede, çalışmanın

amacı; bankaların kredi riski konusunda genel bir çerçeve oluşturmak ve bu konuda geliştirilen risk tahmin modellerine

bir örnek sunmaktır. Çalışmada 2011-2018 yıllarını kapsayan bir örneklem kullanılırken, imalat sanayi

sektöründe yer alan firmaların performansları üzerinden kredi risk modeli geliştirilmeye çalışılmıştır. Elde

edilen sonuçlar; faaliyet kar marjı, duran varlıkların aktif içindeki payı, ticari borçların pasif içindeki payı ve net

satışlara göre mali borç düzeyini gösteren oranların imalat sanayi firmalarının performans değerlendirmesinde

etkili olduğunu göstermektedir.
KİTLE FONLAMASI YÖNTEMİ İLE ZEKÂT UYGULAMASI: BİR MODEL ÖNERİSİ
Authors: KAZAK Hasan
Published: February 2023

Kitle fonlaması, yatırım ihtiyacı olan bir projeyi veya işi finanse edebilmek amacıyla girişimcilerin büyük

insan gruplarından internet tabanlı platformlar vasıtasıyla fon toplamasını ifade eden bir terimdir. Temel mantığı

çok daha öncesine dayanmakla birlikte bugünkü manada kitle fonlaması sisteminin temeli 2008’li yıllara dayanmaktadır.

O günden bugüne popülaritesi sürekli artmış ve güncelliğini halen korumaktadır. Kitle fonlaması

konvansiyonel finans sistemleri açısından olduğu kadar İslami finansal sistemler açısından da oldukça önemlidir.

Kitle fonlaması sistemi İslami yasak ve kurallara uyulması halinde İslami sisteme uyarlanabilir. Bu açıdan

değerlendirildiğinde İslami finansal sistemler içerisinde kitle fonlamasına dayalı sistem ve uygulamaların kurulması

İslam ülkelerinin ekonomik büyüme ve kalkınma süreçlerine katkıda bulunacaktır. Bu çalışmada İslam’ın

en temel emirlerinden birisi olan, İslam ekonomi ve finans sisteminin temelinde yer alan zekât kurumunun kitle

fonlaması yöntemi kullanılarak daha etkin ve verimli şekilde işletilmesine yönelik bir model önerilmiştir. Modelin

özellikle İslam ülkelerinin ekonomik büyüme ve kalkınma süreçlerine katkıda bulunacağı düşünülmektedir.
Striving for a pragmatic contribution of biomarkers results to lifelong health care
Authors: Ferraro Simona , Cereda Cristina , Zuccotti Gianvincenzo , Marcovina Santica , Plebani Mario , Biganzoli Elia Mario
Published: February 2023

Background

The increased role of preventive medicine in healthcare and the rapid technological advancements, have deeply changed the landscape of laboratory medicine. In particular, increased investments in newborn screening tests and policies have been observed. Aim of this paper is to characterize how laboratory professionals engaged in clinical chemistry or newborn screening, in collaboration with experts in econometric, bioinformatics, and biostatistics may address a pragmatic use of laboratory results in the decision-making process oriented toward improvement of health care outcomes.

Content

The effectiveness of biomarkers on healthcare depends on several factors such as analytical performance, prevalence of the disease, integration of the test within the diagnostic algorithm, associated costs, and social/economic impact of false positive and false negative results. Cost-effectiveness analysis needs to be performed and reliability achieved, by overcoming analytical pitfalls and by improving interpretative criteria. These are challenging issues common to clinical chemistry and newborn screening tests. Following the experience in clinical chemistry, one of the main issues to be approached in newborn screening tests, is the lack of harmonization of results obtained by different methods and the limited healthcare effectiveness.

The focus on prevention is a crucial opportunity for laboratory medicine to change how to approach the effectiveness of biomarkers on healthcare. The consolidation within clinical laboratories of professionals with different technical and methodological expertise coupled with the need to produce and manage large sets of data, require the cooperation of professionals from other disciplines to characterize the impact of the tests on epidemiological outcomes for health care policy making process.
No-go zone for Jews? Examining how news on anti-Semitic attacks increases victim blaming
Authors: von Sikorski Christian , Merz Pascal
Published: February 2023

Antisemitism is on the rise. Recently, discussions have considered so-called “no-go zones for Jews” (city areas Jews should avoid to reduce the likelihood of being attacked). In this context and drawing from attribution theory, we examined if news consumers perceive a Jewish hate crime victim as partly responsible for being attacked when news coverage explicitly emphasizes that the victim displayed religious symbols (kippah) in a certain inner-city location. We conducted a quota-based survey experiment (N = 392) in Germany (4 groups, between-subjects design) and randomly exposed participants to news coverage about an anti-Semitic attack. The article either emphasized that the Jewish victim displayed religious symbols (kippah) or not, and highlighted the specific location of the attack (Berlin synagogue vs. deprived inner-city district of Berlin). Moderated mediation analysis suggested that participants perceived the victim’s behavior to be more provocative when the news article highlighted that the victim displayed religious symbols and when the attack occurred in a deprived Berlin district. Yet, effects were only detected for individuals with low (vs. high) levels of education. Perceived provocativeness in turn increased victim blaming indicating that some individuals indirectly regarded the Jewish victim to be partly responsible for being attacked.
Analytical and therapeutic profiles of DNA methylation alterations in cancer; an overview of changes in chromatin arrangement and alterations in histone surfaces
Authors: Norollahi Seyedeh Elham , Vahidi Sogand , Shams Shima , Keymoradzdeh Arman , Soleymanpour Armin , Solymanmanesh Nazanin , Mirzajani Ebrahim , Jamkhaneh Vida Baloui , Samadani Ali Akbar
Published: February 2023

DNA methylation is the most important epigenetic element that activates the inhibition of gene transcription and is included in the pathogenesis of all types of malignancies. Remarkably, the effectors of DNA methylation are DNMTs (DNA methyltransferases) that catalyze de novo or keep methylation of hemimethylated DNA after the DNA replication process. DNA methylation structures in cancer are altered, with three procedures by which DNA methylation helps cancer development which are including direct mutagenesis, hypomethylation of the cancer genome, and also focal hypermethylation of the promoters of TSGs (tumor suppressor genes). Conspicuously, DNA methylation, nucleosome remodeling, RNA-mediated targeting, and histone modification balance modulate many biological activities that are essential and indispensable to the genesis of cancer and also can impact many epigenetic changes including DNA methylation and histone modifications as well as adjusting of non-coding miRNAs expression in prevention and treatment of many cancers. Epigenetics points to heritable modifications in gene expression that do not comprise alterations in the DNA sequence. The nucleosome is the basic unit of chromatin, consisting of 147 base pairs (bp) of DNA bound around a histone octamer comprised of one H3/H4 tetramer and two H2A/H2B dimers. DNA methylation is preferentially distributed over nucleosome regions and is less increased over flanking nucleosome-depleted DNA, implying a connection between nucleosome positioning and DNA methylation. In carcinogenesis, aberrations in the epigenome may also include in the progression of drug resistance. In this report, we report the rudimentary notes behind these epigenetic signaling pathways and emphasize the proofs recommending that their misregulation can conclude in cancer. These findings in conjunction with the promising preclinical and clinical consequences observed with epigenetic drugs against chromatin regulators, confirm the important role of epigenetics in cancer therapy.
Ayurvedic medicine for the treatment of chronic rhinosinusitis: a systematic review of randomized and non-randomized trials
Authors: Schmale Isaac L. , Nimmagadda Sai V. , Ravikumar Saiganesh , Babb Charles N. , Man Li-Xing
Published: February 2023

Objectives

This article provides a comprehensive systematic review and qualitative analysis of the current research investigating Ayurveda chronic rhinosinusitis (CRS) treatment.

Content

PRISMA guidelines for systematic reviews was followed and our search utilized MEDLINE, Embase, Ayush Portal, and Cochrane Library databases. Articles published prior to March 2022, 10 or more patients that investigated Ayurveda as a treatment for CRS in humans were included. This resulted in thirteen articles meeting inclusion criteria. Ayurvedic treatments included herbal medications for oral consumption, nasal instillation, and steam inhalation used alone or in combination. All studies concluded that Ayurvedic therapy led to improvements in subjective CRS symptoms and objective radiographic and hematologic criteria. However, all 13 studies had a significant risk of bias due to study design and statistical methods utilized.

Ayurvedic therapy may be a useful CRS treatment for some patients and overall appears to be well tolerated. However, definitive recommendation for when Ayurvedic treatments would be beneficial in the treatment of CRS remains not possible.

Outlook

Given the overall positive effects shown in the current published evidence and growing interest in complementary and integrative therapies, Ayurvedic treatments for CRS deserve further investigation in the form of well-designed controlled trials.
Application and prospect of artificial intellingence in diabetes care
Authors: Jia Weiping , Fisher Edwin B.
Published: February 2023

Diabetes is one of the fastest-growing non-communicable diseases, becoming an important public health concern worldwide as well as in China. Currently, China has the largest population living with diabetes. Artificial intelligence (AI) is a fast-growing field and its applications to diabetes could enable the delivery of better management services for people with diabetes. This perspective summarized the latest findings of digital technologies and AI use in the following areas of diabetes care, mainly including screening and risk predictions of diabetes and diabetic complications, precise monitoring and intervention combined with new technologies, and mobile health application in self-management support for people with diabetes. Challenges to promote further use of AI in diabetes care included data standardization and integration, performance of AI-based medical devices, motivation of patients, and sensitivity to privacy. In summary, although the AI applications in clinical practice is still at an early stage, we are moving toward a new paradigm for diabetes care with the rapid development and emerging application of AI.
Tunable localization of light using nested invisible metasurface cavities
Authors: Cuesta Francisco S. , Kosulnikov Sergei , Asadchy Viktar S.
Published: February 2023

An invisible cavity is an open resonant device that confines a localized field without producing any scattering outside of the device volume. By exploiting the scatter-less property of such device, it is possible to nest two invisible cavities, as the outer cavity would simply not notice the presence of the inner one, regardless of their relative position. As a result, the position of the inner cavity becomes a means to easily control the field localized inside the cavity and its quality factor. In this paper, we discuss the properties of nested invisible cavities as a simple method to achieve stronger localized fields and high tunable quality factor. Furthermore, we show that in optics, these cavities can be implemented using nanodisk-based dielectric metasurfaces that operate near their electric resonances.
Tunable on-chip mode converter enabled by inverse design
Authors: Zhou Hongyin , Liao Kun , Su Zhaoxian , Li Tianhao , Geng Guangzhou , Li Junjie , Wang Yongtian , Hu Xiaoyong , Huang Lingling
Published: February 2023

Tunable mode converter is a key component of channel switching and routing for optical communication system by adopting mode-division multiplexing. Traditional mode converter hardly implements high-order mode conversion and dynamic tunability simultaneously. In this study, we design a tunable mode converter filled with liquid crystal, which can convert fundamental mode into multiple high-order modes (TE0, TE1, and TE2) with a good performance and low intrinsic loss. For this multiple-objective task, we propose an inverse design framework based on the adjoint method. To experimentally prove our design, a tunable mode converter filled with air or water and a mode demultiplexer are fabricated to implement dynamic routing. The experimental results agree well with the simulation and reveal the crosstalk only around −7 dB. With its performance and efficiency, our proposed design flow can be a powerful tool for multifunction device design.
Crystal structure of ethyl 4-{[5-(adamantan-1-yl)-2-sulfanylidene-2,3-dihydro-1,3,4-oxadiazol-3-yl]methyl}piperazine-1-carboxylate, C20H30N4O3S
Authors: Al-Sanea Mohammad M. , Abdelbaky Mohammed S. M. , Garcia-Granda Santiago , Mohamed Ahmed A. B. , Tiekink Edward R. T. , El-Emam Ali A.
Published: February 2023

C20H30N4O3S, orthorhombic, P212121 (no. 19), a = 7.7152(3) Å, b = 10.6132(2) Å, c = 25.5990(7) Å, V = 2096.12(11) Å3, Z = 4, R
gt(F) = 0.0579, wR
ref(F
2) = 0.1216, T = 293 K.
The crystal structure of furan-2,5-diylbis((4-chlorophenyl)methanol), C18H14Cl2O3
Authors: Yang Yanliang , Li Yadi
Published: February 2023

C18H14Cl2O3, monoclinic, P21/n (no. 14), a = 10.3048(6) Å, b = 8.9620(5) Å, c = 18.0909(10) Å, β = 93.046(6)°, V = 1668.36(16) Å3, Z = 4, R
gt(F) = 0.0646, wR
ref(F
2) = 0.1616, T = 293 K.
A new optimal multistep optimal homotopy asymptotic method to solve nonlinear system of two biological species
Authors: Ayati Zainab , Pourjafar Sadegh
Published: February 2023

Recently solving integro-differential equations have been the focus of attention among many researchers in the field of mathematic and engineering. The aim of current study is to apply the well-known optimal homotopy asymptotic method (OHAM) on a specific and famous model of these equations. It is illustrated that auxiliary functions and the number of Taylor series terms affect the accuracy of the solution. Hence, at first a solution has been found with an acceptable error by OHAM. Then, it has been continued to attain a better solution by Multistep optimal homotopy asymptotic method. All these processes had improved the precision of the solution. Auxiliary polynomials of two, three, and four degrees and different numbers of Taylor series term have been investigated to solve a nonlinear system derived by two biological species ‎living together. Ultimately, appropriate results with auxiliary polynomials of degree four and Taylor series with six terms have been obtained precisely. In addition, the error values decrease significantly compared to the other cases.
Phrase-frames in business emails: a contrast between learners of business English and working professionals
Authors: Xia Detong , Sulzer Mark A. , Pae Hye K.
Published: February 2023

A phrase-frame (p-frame) is a multi-word sequence with a one-word variable within the sequence (e.g., it is * to). P-frames are important components of language production and can demonstrate phraseological patterning. This study examined p-frames retrieved from one learner business emails corpus (1,413 texts based on the Education First-Cambridge Open Language Database) and one working professional email corpus (1,145 texts from the Enron email dataset). P-frames were investigated both quantitatively and qualitatively in terms of their structural characteristics, functional characteristics, and variability. Our results showed that the working professionals and the learners of business English used p-frames differently. The working professionals used p-frames in ways that aligned with written conventions, whereas the learners of business English used p-frames in ways that did not accord well with written conventions. This difference was detected by comparing tendencies in function-word frames and frames for referential function. In addition, p-frames used by the working professionals displayed a higher degree of variability than those by the learners of business English. This study facilitates an understanding of learners’ p-frame use in English for business purposes and suggests that p-frames be incorporated into the teaching and learning of L2 business writing.
Gütekriterien in der Soziologie
Authors: Otte Gunnar , Sawert Tim , Brüderl Josef , Kley Stefanie , Kroneberg Clemens , Rohlfing Ingo
Published: February 2023

Der Artikel entwickelt einen Katalog von elf wissenschaftlichen Gütekriterien für soziologische Forschungsarbeiten aus einer analytisch-empirischen Perspektive. Der Kriterienkatalog umfasst Qualitätsanforderungen an die Theorieentwicklung und die empirische Sozialforschung. Unterschieden werden zwei Basiskriterien, die den gesamten Forschungsprozess betreffen, neun Kernkriterien, die an einzelnen Etappen dieses Prozesses ansetzen, und eine Reihe von Unterkriterien, die der Spezifikation der Kernkriterien dienen. Die Entwicklung der Kriterien erfolgt entlang eines stilisierten Forschungsprozesses, wie er in der quantitativen Sozialforschung üblich ist. Gleichwohl wird der Versuch unternommen, die Kriterien so zu formulieren, dass diese für die qualitative Sozialforschung anschlussfähig sind. Der Beitrag hat zum Ziel, der soziologischen Forschungsgemeinschaft einen aus analytisch-empirischer Perspektive begründeten Referenzrahmen zur Verfügung zu stellen, der die Erarbeitung hochwertiger Forschung anleitet und die Beurteilung von Forschungsleistungen kriteriengeleitet unterstützt.
Embedded religiousness and the Kotosh religious tradition in highland Peru: the site of La Seductora
Authors: Mesia-Montenegro Christian , Sanchez-Borjas Angel
Published: February 2023

Religion played a key role in the social organisation and political authority of early Andean societies. Excavations at La Seductora in Peru have identified a circular structure with a central hearth and an underground ventilation shaft. The authors argue that the structure belongs to the Kotosh religious tradition, which dominated the central Andes during the Late Archaic and Formative periods (2800–550 BC). Probably representing a small shrine for use by local families, the authors situate La Seductora within the context of power and religiosity in Andean society, providing a model of relevance to similar contexts elsewhere in the world.
Neural Substrates of Body Ownership and Agency during Voluntary Movement
Authors: Abdulkarim Zakaryah , Guterstam Arvid , Hayatou Zineb , Ehrsson H. Henrik
Published: February 2023

Body ownership and the sense of agency are two central aspects of bodily self-consciousness. While multiple neuroimaging studies have investigated the neural correlates of body ownership and agency separately, few studies have investigated the relationship between these two aspects during voluntary movement when such experiences naturally combine. By eliciting the moving rubber hand illusion with active or passive finger movements during functional magnetic resonance imaging, we isolated activations reflecting the sense of body ownership and agency, respectively, as well as their interaction, and assessed their overlap and anatomic segregation. We found that perceived hand ownership was associated with activity in premotor, posterior parietal, and cerebellar regions, whereas the sense of agency over the movements of the hand was related to activity in the dorsal premotor cortex and superior temporal cortex. Moreover, one section of the dorsal premotor cortex showed overlapping activity for ownership and agency, and somatosensory cortical activity reflected the interaction of ownership and agency with higher activity when both agency and ownership were experienced. We further found that activations previously attributed to agency in the left insular cortex and right temporoparietal junction reflected the synchrony or asynchrony of visuoproprioceptive stimuli rather than agency. Collectively, these results reveal the neural bases of agency and ownership during voluntary movement. Although the neural representations of these two experiences are largely distinct, there are interactions and functional neuroanatomical overlap during their combination, which has bearing on theories on bodily self-consciousness.

SIGNIFICANCE STATEMENTHow does the brain generate the sense of being in control of bodily movement (agency) and the sense that body parts belong to one's body (body ownership)? Using fMRI and a bodily illusion triggered by movement, we found that agency is associated with activity in premotor cortex and temporal cortex, and body ownership with activity in premotor, posterior parietal, and cerebellar regions. The activations reflecting the two sensations were largely distinct, but there was overlap in premotor cortex and an interaction in somatosensory cortex. These findings advance our understanding of the neural bases of and interplay between agency and body ownership during voluntary movement, which has implications for the development of advanced controllable prosthetic limbs that feel like real limbs.
LACTIPLANTIBACILLUS PLANTARUM EK148’İN ET PROTEİNLERİ İÇEREN ORTAMDA GAMA AMİNO BÜTİRİK ASİT ÜRETİMİ VE OPTİMİZASYONU
Authors: KAMİLOĞLU Aybike , MEMİŞ Habibe
Published: February 2023

Araştırmada, sucuk kaynaklı Lactiplantibacillus plantarum EK148 suşu gama amino bütirik asit (GABA) üretim düzeyi açısından değerlendirilmiştir. GABA üretimine, monosodyum glutamat (MSG) bulunmayan besi ortamına glutamik asit kaynağı olarak et protein izolatı edilerek, sıcaklık, pH ve fermantasyon süresi faktörlerinin etkisi değerlendirilmiştir. Deneysel tasarımda elde edilen yanıtlarla L. plantarum EK148 suşu için optimum koşullar % 10 protein ekstraktı konsantrasyonu, 33.3 ºC sıcaklık, pH 5.05 ve 96 saat fermantasyon süresi olarak belirlenmiştir. Model ile L. plantarum EK148 suşu kullanılarak elde edilen veriler arasındaki uyum eksikliğinin önemsiz olduğu, protein ekstraktı konsantrasyonu ve sıcaklığın GABA üretimi üzerine önemli düzeyde etkili olduğu tespit edilmiştir. Yapılan bu çalışma ile et proteinlerinin glutamik asit kaynağı olarak kullanımı sağlanmış ve MSG içermeyen ortamda L. plantarum EK148 suşu kullanılarak GABA üretimi gerçekleştirilmiştir.
Structure and function of the western Baffin Bay coastal and shelf ecosystem
Authors: Pedro Sara , Lemire Mélanie , Hoover Carie , Saint-Béat Blanche , Janjua Muhammad Y. , Herbig Jennifer , Geoffroy Maxime , Yunda-Guarin Gustavo , Moisan Marie-Ange , Boissinot Justin , Tremblay Jean-Éric , Little Matthew , Chan Laurie , Babin Marcel , Kenny Tiff-Annie , Maps Frédéric
Published: February 2023

Arctic marine species, from benthos to fish and mammals, are essential for food security and sovereignty of Inuit people. Inuit food security is dependent on the availability, accessibility, quality, and sustainability of country food resources. However, climate change effects are threatening Inuit food systems through changes in abundance and nutritional quality of locally harvested species, while foundational knowledge of Arctic food webs remains elusive. Here, we summarized scientific knowledge available for the western Baffin Bay coastal and shelf ecosystem by building a food web model using the Ecopath with Ecosim modeling framework. Based on this model, we calculated ecological network analysis indices to describe structure and function of the system. We used Linear Inverse Modeling and Monte Carlo analysis to assess parameter uncertainty, generating plausible parameterizations of this ecosystem from which a probability density distribution for each index was generated. Our findings suggest that the system is controlled by intermediate trophic levels, highlighting the key role of Arctic cod (Boreogadus saida) as prey fish, as well as the importance of other less studied groups like cephalopods in controlling energy flows. Most of the ecosystem biomass is retained in the system, with very little lost to subsistence harvest and commercial fisheries, indicating that these activities were within a sustainable range during the modeling period. Our model also highlights the scientific knowledge gaps that still exist (e.g., species abundances), including valued harvest species like Arctic char (Salvelinus alpinus), walrus (Odobenus rosmarus), and seals, and importantly our poor understanding of the system in winter. Moving forward, we will collaborate with Inuit partners in Qikiqtarjuaq, NU, Canada, to improve this modeling tool by including Inuit knowledge. This tool thus serves as a starting point for collaborative discussions with Inuit partners and how its use can better inform local and regional decision-making regarding food security.
Expanding the use of salivary cortisol as a non-invasive outpatient test in the dynamic evaluation of suspected adrenal insufficiency
Authors: Tan Sarah Ying Tse , Tan Hong Chang , Zhu Ling , Loh Lih Ming , Lim Dawn Shao Ting , Swee Du Soon , Chan Yoke Ling , Lim Huee Boon , Ling Shiau Lee , Ou En Jun , Teo Wynn Ee , Zhang Xiao Ping , Goh Hui Fen , Kek Peng Chin
Published: February 2023

Background

Adrenal insufficiency (AI) is potentially life-threatening, and accurate diagnosis is crucial. The first-line diagnostic test, the adrenocorticotrophic hormone (ACTH) stimulation test, measures serum total cortisol. However, this is affected in states of altered albumin or cortisol-binding globulin levels, limiting reliability. Salivary cortisol reflects free bioactive cortisol levels and is a promising alternative. However, few studies are available, and heterogenous methodologies limit applicability.

Methods

This study prospectively recruited 42 outpatients undergoing evaluation for AI, excluding participants with altered cortisol-binding states. Serum (immunoassay) and salivary (liquid chromatography tandem mass spectrometry) cortisol levels were sampled at baseline, 30 min, and 60 min following 250 µg synacthen administration. AI was defined as a peak serum cortisol level <500 nmol/L in accordance with guidelines.

Results

The study recruited 21 (50%) participants with AI and 21 without AI. There were no significant differences in baseline characteristics, blood pressure, or sodium levels between groups. Following synacthen stimulation, serum and salivary cortisol levels showed good correlation at all timepoints (R2 = 0.74, P < 0.001), at peak levels (R2 = 0.72, P < 0.001), and at 60 min (R2 = 0.72, P < 0.001). A salivary cortisol cut-off of 16.0 nmol/L had a sensitivity of 90.5% and a specificity of 76.2% for the diagnosis of AI.

Conclusion

This study demonstrates a good correlation between serum and salivary cortisol levels during the 250 µg synacthen test. A peak salivary cortisol cut-off of 16.0 nmol/L can be used for the diagnosis of AI. It is a less invasive alternative to evaluate patients with suspected AI. Its potential utility in the diagnosis of AI in patients with altered cortisol-binding states should be further studied.
Análisis de la velocidad de la luz en el vacío de un medio resistente
Authors: Monroy Oscar , Merma Marco
Published: February 2023

The propagation of light is studied as a mechanism for the transmission of organized information through the underlying void of a resistant homogeneous medium. A substrate compatible with the inherent kinematic viscosity of the medium is constructed, which is defined by a system of parametric equations compatible with the properties of the medium. As a consequence, an equation is obtained for the speed of light that varies with time for a given magnitude of the local vector quantum associated with the resistant medium. The equation obtained indicates the transmission of organized information in the medium and shows a double direction that would be correlated with the opposite vector quanta. These vector quanta would not be exactly opposite and would exhibit excess and defect fluctuations reciprocally. Thus, for quasi-equilibrium states of the natural system, the fluctuations of the vector quanta would be small with respect to the magnitude of the representative vector quantum, and for disequilibrium states the fluctuations would be large or comparable with respect to the magnitude of the representative vector quantum. The results are used to study the functioning of the intracellular virion, and it is deduced that for each viral particle there would be a viral antiparticle with opposite properties in its nucleic acid. Finally, a reduced equation for the speed of light is obtained that describes the replication speed of the viral particle as a function of the number of steps in the conical nucleic acid spiral and the light absorption coefficient.
Розроблення нових функціональних матеріалів для потреб водневої енергетики
Authors: Завалій Ігор Юліянович
Published: February 2023

У доповіді наведено найважливіші результати фундаментальних та прикладних досліджень, проведених у Фізико-механічному інституті імені Г.В. Карпенка НАН України, завдяки яким в Україні створено науково-технічну базу для розроблення сучасних функціональних матеріалів для акумулювання і генерування водню та конструкційних матеріалів для інтерконектів паливних комірок, а також пристроїв для постачання водню у відповідних автономних джерелах енергії.
Цитування: Завалій І.Ю. Розроблення нових функціональних матеріалів для потреб водневої енергетики. Вісник НАН України. 2023. № 1. С. 50—56. https://doi.org/10.15407/visn2023.01.050
Károly Kós. Henri Godbarge
Authors: de Montety Henri
Published: February 2023

Károly Kós and Henri Godbarge were both architects with strong ideas on local roots. Following the Arts & Craft and Art nouveau movements, they respectively contributed to the Transylvanism and néo-basque styles, which have many things in commun, particularly a special connection to the Orient(s), to social and family realities and to the ancestors.
Effects of different feeds on growth performance and meat quality of hybrid lambs
Authors: Zhang Taiwu , Wang Shaohua , Liu Rong , Liu Ting , Zhang Yanni , Yang Le , Kang Letian , Xie Junkang , Jin Ye , Duan Yan
Published: February 2023

To improve the meat quality of Nei Mongol mutton and the benefits for farmers, we selected Australian salmon hybrid lambs as experimental subjects to investigate the effects of Allium mongolicum Regel powder (AMR) and yeast-fermented distiller’s grains (DGS) on their production performance and economic efficiency. The results showed that the DGS group had higher kidney index, the AMR group had better meat quality, and the economic efficiency ratio of DGS and AMR was 2.08. In conclusion, both feeds had no adverse effects on the production performance of lambs, and the DGS group had greater potential for promotion.
Is the best resistance strategy against begomoviruses yet to come? A Comprehensive Review
Authors: Ishfaqe Qandeel , Shafiq Muhammad , Ali Mubashra Raza , Haider Muhammad Saleem
Published: February 2023

ABSTRACT The worldwide spread of Geminiviruses and its vector has been attributed to the high rate of recombination, mutation, presence of alternate hosts, transport of plant material, global human activity along with global trade, new agricultural practices and climate change; therefore, the most severe viral diseases among crops have grown in almost all regions of the world, including cassava viral diseases in Africa, cotton leaf curl disease in Pakistan, and multiple diseases related to tomatoes, legumes and cucurbits in India and all over the world. Begomovirus is the major and largest genus of Geminiviridae which has shown a worldwide increase in its variations and distribution by affecting previously unaffected plants. The increasing population has augmented the demand for a sustainable agriculture boost, but begomoviruses have become a continual threat to the world’s agriculture. Numerous control strategies have been used for the viral invasion of the world as pathogens but begomoviruses continually overcome the control methods, and this has generated a need to end this competition between researchers and begomoviruses. The present review summarizes all strategies used against begomoviruses and provides a comprehensive comparison among all control methods, their drawbacks, and future insights.
Implementação do Programa Saúde na Escola: relação com aspectos da saúde bucal dos estudantes
Authors: Moreira Rafael da Silveira , Mauricio Herika de Arruda , Jordão Lidia Moraes Ribeiro , Freire Maria do Carmo Matias
Published: February 2023

RESUMO O estudo objetivou investigar a associação entre a implementação do Programa Saúde na Escola (PSE) e aspectos relacionados com a saúde bucal de adolescentes escolares que frequentam escolas públicas no Brasil. Foi realizado estudo transversal exploratório utilizando dados da Pesquisa Nacional de Saúde Escolar (PeNSE) 2015 em uma amostra de 81.154 estudantes de 13 a 15 anos frequentando escolas públicas das capitais, Distrito Federal e interior. Os dados foram obtidos por meio de questionários respondidos pelos alunos e responsáveis pelas escolas. Foi realizada análise bivariada de associação entre a variável ‘implementação das ações do PSE pela escola’ (Sim/Não) e aspectos relativos à saúde bucal dos estudantes. Em comparação com escolas sem implementação do PSE, as que haviam implementado o Programa apresentavam melhores indicadores de comportamento (consumo de alimentos com açúcar adicionado, cigarro e álcool); venda de alimentos saudáveis ou com açúcar adicionado; existência de grupo/comitê de saúde, ações do Programa Mais Educação e ações em conjunto com a Unidade Básica de Saúde (p<0,05). Concluiu-se que houve associação entre a implementação do PSE e aspectos mais favoráveis relacionados com a saúde bucal, referentes a alimentação, uso de cigarro e álcool entre os escolares, e ações de saúde e educação nas escolas.
Implementation of the School Health Program: relationship with aspects of students’ oral health
Authors: Moreira Rafael da Silveira , Mauricio Herika de Arruda , Jordão Lidia Moraes Ribeiro , Freire Maria do Carmo Matias
Published: February 2023

ABSTRACT This study aimed to investigate the association between the School Health Program (PSE) implementation and aspects related to the oral health of adolescent students attending public schools in Brazil. An exploratory cross-sectional study was conducted using data from the 2015 National School Health Survey (PeNSE) in a sample of 81,154 students aged 13 to 15 in the capitals, Federal District, and inland cities. Data were retrieved from questionnaires answered by students and those responsible for the schools. We performed a bivariate analysis of the association between the variable ‘implementation of PSE actions by the school’ (Yes/No) and aspects related to the students’ oral health. Compared to schools without PSE implementation, those that had implemented the Program had better behavioral indicators (consumption of sugar-added foods, cigarettes, and alcohol); selling healthy or sugar-added foods; availability of a health group/committee, and actions of the More Education Program and with Primary Health Care Units (p<0.05). We concluded that there was an association between the implementation of the PSE and more favorable aspects related to oral health regarding the students’ diet, tobacco use, and alcohol consumption, and school health and education actions.
Programa Saúde na Escola: projeto de intervenção contra a dengue em Matinhos-PR
Authors: Gonçalves Eduarda Cristina Poletto , Kligerman Debora Cynamon , Cohen Simone Cynamon , Kleinubing Neilor Vanderlei
Published: February 2023

RESUMO O Programa Saúde na Escola (PSE) objetiva promover ações de saúde nas escolas por meio de ferramentas pedagógicas desenvolvidas entre a saúde e a educação. Foi realizado um estudo na cidade de Matinhos-PR pelo PSE, na abrangência da escola municipal Luiz Carlos dos Santos, incluindo 60 estudantes dos 5.os anos, no período de março a agosto de 2019. Utilizaram-se características da pesquisaação participativa e metodologia da problematização, sendo um tipo de estudo social e qualitativo. Para o levantamento dos dados, utilizou-se o método do Arco de Charles de Maguerez. Como resultado da pesquisa, desenvolveu-se, na escola e na comunidade, uma ferramenta pedagógica, o projeto de intervenção ‘Escola, saúde, ambiente e comunidade mobilizados contra o Aedes aegypti’. O estudo comprovou que a aplicação de políticas públicas já existentes como o PSE, por intermédio da intersetorialidade, a educação em saúde ambiental e ações de controle vetorial mecânico, sem aplicabilidade de veneno, são medidas apropriadas para prevenção de doenças, como a eliminação de criadouros de vetores; efetivando, assim, o uso da educação em saúde ambiental nas escolas como uma estratégia de promoção da saúde.
Violência contra crianças e adolescentes: intervenções multiprofissionais da Atenção Primária à Saúde na escola
Authors: Anunciação Leilane Lacerda , Carvalho Rosely Cabral de , Santos José Eduardo Ferreira , Morais Aisiane Cedraz , Almeida Vivian Ranyelle Soares de , Souza Sinara de Lima
Published: February 2023

RESUMO Trata-se de um recorte de uma dissertação de mestrado, com objetivo de descrever o processo de construção de propostas de prevenção, enfrentamento e atenção à violência intrafamiliar e escolar contra crianças e adolescentes estudantes em um bairro periférico de um município do interior baiano. Foi realizado um estudo com abordagem qualitativa, descritiva, exploratória; por meio da pesquisa-ação. Os atores sociais da pesquisa foram a comunidade escolar, a família e profissionais de saúde. Os dados foram coletados pela observação sistemática, rodas de conversas e seminário, utilizados para diagnóstico situacional e desenvolvimento das intervenções. A interpretação dos dados foi realizada pela análise de conteúdo. As atividades desvelaram a relevância do trabalho desenvolvido em rede intersetorial e multiprofissional qualificada, resultando em: mudanças comportamentais de adolescentes na escola e família, protagonismo destes nas oficinas educativas para cultura da paz, implantação de espaço de mediação de conflitos na escola, criação de projeto de atividade física, aproximação de pais à escola e sensibilização quanto a melhores possibilidades de educação doméstica não violentas. Conclui-se que as intervenções iniciaram um movimento de mudança de práticas e de interlocução dos diversos serviços existentes no bairro, resultando em uma construção gradual de territórios de paz na escola e na comunidade.
Hesperozygis ringens essential oil as an anesthetic for Colossoma macropomum during biometric handling
Authors: Ferreira Andre Lima , Souza André de Sena , Santos Fábio Aremil Costa dos , Pinheiro Carlos Garrido , Favero Gisele Cristina , Heinzmann Berta Maria , Baldisserotto Bernardo , Luz Ronald Kennedy
Published: February 2023

ABSTRACT: This study evaluated the effectiveness of the essential oil of Hesperozygisringens (EOHR) for anesthesia of Colossomamacropomum by documenting hematological and blood biochemical responses after biometric handling. In Experiment 1, juveniles (14.12 ± 3.53 g) were exposed to different concentrations of EOHR: 0 (control), 75, 150, 300 and 450 µL L-1 (n=10 fish for each concentration), to determine times for induction and recovery from anesthesia, as well as its effects on ventilatory frequency (VF). Based on these results, Experiment 2 evaluated the effects of 0 (control), 75 (with induction and recovery times outside that recommended for fish anesthesia) and 150 µL L-1 EOHR (within recommended times) on hematological and biochemical variables of juveniles (20.52 ± 3.47 g) after anesthesia and after 24 h of recovery (n = 6 fish for each concentration and collection time). Survival was 100%. Induction time showed a quadratic effect of EOHR concentration. Recovery time did not differ among EOHR concentrations. Concentrations between 150 and 450 µL L-1 EOHR caused rapid induction (< 3 min) and recovery (< 5 min). EOHR concentration affected VF. The concentration of 150 µL L-1 EOHR had little influence on hematological and biochemical parameters of C. macropomum of 20 g.