bluuebunny/crossref_metadata_2025 huggingface dataset:
Relationship between urethrovesical junction mobility changes and postoperative progression of stress urinary incontinence following sacrospinous ligament fixation – a subanalysis of a multicentre randomized study
Authors:   Department of Gynecology, TGM Hodonín Hospital, c.o., Czech Republic, Gágyor Daniel , Pilka Radovan , Benická Alžběta , Kališ Vladimír , Rušavý Zdeněk , Krofta Ladislav , Němec Martin , Mašata Jaromír
Published: August 2022

Objectives: The study aimed to assess the relationship between urethrovesical junction (UVJ) descent and development of de novo stress urinary incontinence (SUI) and postoperative progression of preexisting SUI following surgery for pelvic organ floor prolapse using the method of sacrospinal fixation (SSF). This was a secondary analysis of the SAME prospective randomized multicentre study (reg. no. NCT03053479) comparing three approaches to surgery for apical defects – sacropexy, SSF and transvaginal mesh. Methods: The subanalysis included 81 patients with apical defects managed by SSF, either right-sided (N = 14, 17.3%) or bilateral (N = 67, 82.7%). Postoperative follow-up was assessed at 3 months (N = 59), 12 months (N = 47) and 24 months (N = 30). UVJ mobility at rest and with maximum eff ort, the Valsalva manoeuvre was determined using a standardized 3D/4D transperineal ultrasound protocol proposed by Dietz et al. De novo SUI and postoperative progression of preexisting SUI were ascertained from history. Results: Preoperative demographic data (N = 81) were as follows: BMI 27.3 kg/m2 (16.8–44.5), age 67.0 years (31–85), and parity 2 (1–6). Concomitant anterior repair was performed in 65.4%. Postoperative progression of SUI was 45.8% at 3 months, 21.3% at 12 months, and 23.3% at 24 months. There were significant differences between preoperative and postoperative UVJ descent values at 3, 12 and 24 months (P < 0.0001). Correlations between UVJ descent at 3, 12 and 24 months postoperatively and de novo SUI or progression of preexisting SUI at 3, 12 and 24 months postoperatively were not statistically significant (P = 0.051–0.883). Correlations between differences (preoperative UVJ descent minus UVJ descent at 3, 12 and 24 months postoperatively) and de novo SUI or progression of preexisting SUI at 3, 12 and 24 months postoperatively were not statistically significant (P = 0.691–0.779). Conclusions: The study showed significant changes in UVJ descent values preoperatively and at 3, 12 and 24 months after SSF. There were no significant correlations between UVJ descent and de novo SUI and postoperative progression of preexisting SUI following surgery for pelvic organ floor prolapse at 3-, 12- and 24-month follow-up. There were no significant correlations between differences (preoperative UVJ descent minus UVJ descent at 3, 12 and 24 months postoperatively and de novo SUI and postoperative progression of preexisting SUI following surgery for pelvic organ floor prolapse at 3-, 12- and 24-month follow-up. Key words: pelvic organ prolapse – stress urinary incontinence – sacrospinous ligament fixation – pelvic floor ultrasound – urethrovesical junction mobility
Timing of caesarean section and its impact on levator ani musle avulsion at the first subsequent vaginal birth – a pilot study
Authors:   Department of Gynecology and Obstetrics, Charles University Medical Faculty and University Hospital Plzeň, Czech Republic, Paymová Lenka , Švabík Kamil , Kališ Vladimír , Mostafa Ismail Khaled , Rušavý Zdeněk
Published: August 2022

Objective: The aim of this multicentric observational study was to explore the impact of the timing of cesarean section (SC) on levator (MLA – levator ani musle) avulsion at the fi rst subsequent vaginal birth. Methods: All women after term vaginal birth following a cesarean section (VBAC) for their second delivery at the Departments of Gynecology and Obstetrics, Faculty of Medicine, Charles University and University Hospital in Pilsen and the 1st Faculty of Medicine, Charles University and General Hospital in Prague, between 2012 and 2016 were identified. Hospital database and surgical notes were used to collect basic characteristics of the patients including the indication and course of their previous delivery. These women were divided into two groups according to indication of prior SC in the previous delivery to women with elective SC and acute SC. All participants were invited for a 4D pelvic floor ultrasound to assess levator trauma. Levator avulsion and the levator hiatus area were assessed off-line from the stored pelvic floor volumes. Data were statistically assessed. Results: A total of 356 women had a VBAC for their second delivery during the study period. Of these, 152 (42.7%) attended the ultrasound examination and full data were available for 141 women for statistical analyses. These were further divided into 80 women after acute SC and 61 women after elective SC. The levator avulsion rate was higher in the elective SC subgroup, but the difference was not significant (26.3 vs. 41.0%, P = 0.0645). No statistical differences in urogenital hiatus enlargement and ballooning were observed. Conclusion: VBAC is associated with a significantly higher rate of levator ani avulsion compared to the first vaginal birth in nulliparous women. However, it seems that risk of levator ani avulsion doesn’t depend on the timing of SC in previous labor. More studies are needed to confirm the results of this pilot study. Key words: 4D transperineal ultrasound – levator ani muscle – avulsion injury – vaginal birth after cesarean section – pelvic floor
Systemic lupus erythematosus and secondary antiphospholipid syndrome in native sisters with reduced fertility
Authors:   Genetika-Plzeň s.r.o., Next-Clinics Czech a.s., Plzeň, Czech Republic, Ulčová-Gallová Zdenka , Mukenšnabl Petr , Dzurillová Žaneta , Lošan Petr
Published: August 2022

Objective: Systemic lupus erythematosus (SLE) and secondary anti-phospholipid syndrome (APS II) can cause increased morbidity and mortality of the fetus. We followed the course of fertility of two sisters with these two basic diseases. Methods: In the Center for Immunology of Reproduction, we confirmed both sisters had increased levels of some selected anti-phospholipid antibodies (against phosphatidylserine, phosphatidylethanolamine, phosphatidylinositol, DL-glycerole, anexin V, phoshatidic acid, cardiolipin, beta2-glycoprotein I), anti-nuclear, and anti-DNA antibodies. During the established immunosuppressive and hormonal therapy at the time of SLE remission, both sisters became pregnant. There was a physiological progression of pregnancy until the 19th week. Results: At the 20th week of pregnancy, the older sister miscarried again, and the younger sister developed hypertension in the 31st week of pregnancy which was terminated by caesarean section. Conclusion: In our causal evaluation, we addressed two serious autoimmune diseases (SLE, APS II) in two sisters and described their course of pregnancy. However, only one of them became a happy mother. Key words: infertility – systemic lupus erythematosus – secondary antiphospholipid syndrome
Ovarian tumors and genetic predisposition
Authors:   Institute of Medical Genetics, Olomouc University Hospital, Czech Republic, Štellmachová Júlia , Vrtěl Petr , Vrtěl Radek , Janíková Mária , Kolaříková Kristýna , Procházka Martin , Vodička Radek
Published: August 2022

Objective: Summary of knowledge in the field of ovarian cancer and genetic predisposition. Results: Ovarian tumors are usually diagnosed at advanced stages of the disease and the prognosis for these patients is generally poor. The 5-year overall survival rate, regardless of the histopathological type of tumor, is around 44%. Germline mutations causing hereditary tumor syndromes are predominantly involved in the development of epithelial ovarian tumors. The most common is hereditary breast and ovarian cancer syndrome, which is caused by germline mutations in the tumor suppressor genes BRCA1 and BRCA2. Several other tumor suppressor genes and oncogenes are known to be associated with ovarian tumors and cause other types of tumor syndromes. Inherited tumor syndromes include Lynch syndrome, Peutz-Jegers syndrome, Gorlin syndrome, Li-Fraumeni syndrome and others. The indication for genetic examination of germline mutations is given by a clinical geneticist on the basis of the recommendation of the attending physician. At present, every ovarian tumor, primary peritoneal tumor and tube tumor diagnosed at any age is indicated for genetic testing. Conclusion: Early identification of genes for hereditary cancer syndromes, thanks to rapidly developing molecular genetic methods, is an important step towards personalized treatment of ovarian cancer and preventive measures in families at risk. It is also important to note that a negative molecular genetic test result does not exclude genetic risk. Key words: ovarian cancer – germinal variant – hereditary tumor syndrome – molecular-genetic examination – prevention – familial mutations – genetic risks
Steroid metabolome and multiple pregnancy
Authors:   Department of Gynecology and Obstetrics, First Medical Faculty, Charles University and General Hospital in Prague, Czech Republic, Černý Andrej , Laštůvka Zdeněk , Hill Martin , Pařízek Antonín
Published: August 2022

Steroid bio synthesis occurs in adrenal, gonadal, brain, liver, and placental tissues. Depending on the location of their activity, steroids can be divided into two groups – intracellular and extracellular. Intracellular ones act as transcription factors, suppressing or activating gene expression – they have a so-called genomic effect and therefore their onset of action is slow. Steroids acting extracellularly (non-genome effect) bind to neurotransmitter receptors located on the cytoplasmic cell membrane and thus affect the permeability of the ion channels, the effect of which is much faster, and we refer to them as neuroactive steroids or neurosteroids. While neuroactive steroids can be produced in different tissues of the body, or can be administered externally, neurosteroids are synthetized in cells of the nervous system. Some neuroactive steroids whose levels are extremely elevated in pregnancy (progesterone and its metabolites) are crucial in stabilizing pregnancy and changes in their concentration may influence the onset of parturition. Steroidogenic disorders may be involved in a number of pregnancy pathologies such as premature birth, pre-eclampsia, intrahepatic cholestasis in pregnancy, etc. Our research in collaboration with the Department of Steroids and Proteofactors of the Institute of Endocrinology in Prague also focuses on the investigation of multiple pregnancies in terms of bio synthesis, transport, and the effects of steroids. Studies available in the literature so far have not provided a comprehensive analysis of the steroidome in children and mothers in multiple pregnancies. The aim of our research is therefore to clarify the relationships between fetuses and mothers and between fetuses from the point of view of steroid synthesis and transport as well as the physiology and pathophysiology of human pregnancy and childbirth. Key words: fetomaternal steroidome – neuroactive steroids – pregnancy complication – multiple pregnancy
Conteúdo e forma da escola na perspectiva dos estudantes
Authors: Dalmagro Sandra Luciana
Published: August 2022

O artigo relaciona a forma escolar, tal como definida na literatura, com a percepção dos estudantes quanto à organização do trabalho escolar e pedagógico. A pesquisa de campo foi realizada em três escolas portuguesas com características diferenciadas entre si: duas de perfil tradicional sendo uma de localização periférica e outra voltada a setores sociais elitizados. Uma terceira escola foi selecionada por adotar métodos inovadores. Realizamos observações nas turmas, grupos focais com estudantes e entrevistas com docentes. O suporte teórico advém das perspectivas críticas, sobretudo Enguita (1989), o qual destaca o isomorfismo entre sociedade e escola burguesa. As escolas de perfil tradicional foram objeto de críticas pelos estudantes. A de periferia revela a formação para inserção social precária e um cunho assistencial, enquanto a escola voltada às elites mostrou-se mais enrijecida em seus métodos, sofrendo grande rejeição estudantil.  Aquela com proposta pedagógica inovadora alcança algumas mudanças na forma escolar e atrai o interesse e o envolvimento dos estudantes. Concluímos que a escola precisa ser transformada radicalmente em seu conteúdo e forma para estar em sintonia com as novas gerações e os desafios da sociedade atual, mas o conjunto social igualmente precisa ser revolucionado pois, no limite, é este que modula o conteúdo, a forma e os sentidos que os sujeitos imprimem à escola.
O ensino da geometria nos primeiros anos (1965-1974) em Portugal: diálogo entre os programas e os materiais de formação dos professores
Authors: Almeida Mária Cristina , Candeias Rui
Published: August 2022

Este artigo pretende aprofundar o conhecimento sobre o ensino da Matemática nos primeiros anos de escolaridade, estabelecendo um diálogo entre as propostas curriculares obrigatórias para o ensino da Geometria e as indicações didáticas transmitidas aos professores através de manuais de didática e de orientações para o ensino. Analisámos por um lado, os programas portugueses obrigatórios para a Matemática do ensino primário e para a Telescola, procurando conhecer os conteúdos, as orientações e os materiais didáticos relativos à Geometria referidos nesses documentos. Por outro lado, olhámos para os materiais da formação de professores do ensino primário e para as orientações para o ensino da Matemática na Telescola, em busca das indicações didáticas aí preconizadas para o ensino da Geometria. O período escolhido insere-se numa época em que circulavam internacionalmente ideias de renovação do ensino da matemática, o Movimento da Matemática Moderna, pelo que também procurámos a influência deste movimento nos materiais analisados. O estudo é baseado numa análise documental, de natureza descritiva e interpretativa, com uma perspetiva histórica. As fontes utilizadas englobam os programas em vigor na época e os materiais produzidos especificamente para professores, ou para futuros professores, que contêm indicações didáticas. De uma forma geral, os materiais produzidos especificamente para professores, ou para futuros professores, centram-se na componente pedagógica e seguem as indicações dos documentos curriculares oficiais na abordagem proposta. A análise evidenciou uma preocupação em adequar o ensino de geometria à faixa etária dos alunos favorecendo uma abordagem simultaneamente utilitária, formativa, intuitiva e ativa.
Nuclear ribosomal phylogeny of Brachystegia: new markers for new insights about rain forests and Miombo woodlands evolution
Authors: Boom Arthur F. , Migliore Jérémy , Kaymak Esra , Meerts Pierre , Hardy Olivier J.
Published: August 2022

Background and aims – Brachystegia is a species-rich tree genus found in tropical Africa and a typical element of Miombo woodlands, a widely distributed subtype of the Zambezian savanna. Plastid DNA was shown to be largely uninformative to assess species phylogenetic relationships due to widespread chloroplast capture among species. Here, we aim to assess the capacity of nuclear ribosomal DNA (rDNA) to clarify the phylogeny of Brachystegia species while accounting for intra-individual site polymorphisms (2ISPs), which are often present in rDNA and potentially phylogenetically informative.

Material and methods – Genome skimming sequencing on 47 samples representing 27 of the 29 currently recognized Brachystegia species, allowed us to retrieve complete nuclear ribosomal cistrons encoding for 18S, 5.8S, and 25S rRNA genes (35S rDNA). We reconstructed the Brachystegia phylogeny using Maximum Likelihood methods based on the standard substitution model or integrating 2ISPs (GENOTYPE implementation in RAxML-NG). We additionally tested the effect of partitioning the data (one partition for rDNA genes and one for the ITS1+ITS2). We also conducted network inferences (Neighbor-Net splits graph), as a strict bifurcative approach might not properly model topological uncertainty at shallow phylogenetic depth.

Key results – 2ISPs-aware and standard phylogenetic reconstructions are largely congruent. We identified several well-supported main clades clarifying the species relationships, including two clades of Miombo woodlands species. Miombo Group A includes species with ovoid to globose axillary dormant buds, while Miombo Group B species have flattened ones. Two morphologically close Brachystegia species (B. kennedyi and B. leonensis) found in Guineo-Congolian rain forests form also a robustly supported clade. 2ISPs coding allowed to identify an additional Guineo-Congolian clade (B. eurycoma and B. nigerica). Ribosomal DNA therefore proves more useful to explore the generic phylogeny than plastid DNA but the species relationships within and among the main clades remain poorly resolved, probably due to recent diversification and/or recurrent hybridization, so that the diversification of Brachystegia remains to be more properly characterised.

Conclusion – Nuclear and plastid phylogenetic reconstructions of Brachystegia species are discordant. Even if not well-resolved, rDNA phylograms and networks are characterized by taxonomic sorting, while we observe a strictly geographic sorting in the plastid dataset. Most of the species’ relationships remain to be characterized using additional nuclear markers combined with in-depth morphological investigations.
Biological effects caused by the pharmaceuticals losartan and diclofenac, and their mixture on marine organisms
Authors: Andrade de Sousa Juliana , Hermes Pusceddu Fabio , Dos Santos Barbosa Ortega Andressa , Ueda de Carvalho Maysa Ueda de Carvalho , Amaral Gomes dos Santos Rafaela , Moledo de Souza Abessa Denis , Dias Seabra Pereira Camilo , Alves Maranho Luciane
Published: August 2022

Studies show that pharmaceuticals are being taken to the oceans causing contamination and toxicity to aquatic organisms. The present study evaluated the survival rate of microcrustaceans Artemia salina and the abnormal embryo larval development rate of sea urchin Echinometra lucunter, after exposure to the drug Losartan, an antihypertensive drug, and the drug Diclofenac, a non-steroidal antiinflammatory drug (NSAID), in addition to its mixture among its compounds. Acute toxicity tests were carried out using A. salina and chronic toxicity tests were carried out using embryos of E. lucunter. Organisms were exposed to isolated pharmaceuticals at different concentrations: 1.56 mg.L-1; 3.12 mg.L-1; 6.25 mg.L-1; 12.5 mg.L-1; 25 mg.L-1; 50 mg.L-1 and 100 mg.L-1, and their mixture at concentrations: 0.78 mg.L-1; 1.56 mg.L-1; 3.12 mg.L-1; 6.25mg.L-1; 12.5 mg.L-1; 25 mg.L-1 and 50 mg.L-1. The result obtained in the acute toxicity test did not show toxicity to A. salina. Chronic toxicity test with losartan did not show toxicity to sea urchin embryos, in contrast, the isolated diclofenac showed chronic toxicity at NOEC = 6.25 mg.L-1, LOEC = 12.5 mg.L-1 and IC50 = 62.15 mg.L-1. The result obtained with embryos exposed to the mixture of losartan and diclofenac, showed chronic toxicity at NOEC= 6.25 mg.L-1 and LOEC= 12.5 mg.L-1, not being possible to show the IC50. Our results suggest that the mixture of the two studied pharmaceuticals might decrease the toxicity, since diclofenac showed higher chronic toxicity to E. lucunter embryo larval development when it was isolated than when it was mixed with losartan. However, there is a need for further ecotoxicological studies that clarify the pathways of these pharmaceuticals in non-target organisms.
HUBUNGAN ANTAR USIA KEHAMILAN DENGAN JUMLAH LEUKOSIT PADA IBU HAMIL DI PUSKESMAS SLAHUNG PONOROGO
Authors: Suryani Eka , Widhiyastuti Endang
Published: August 2022

Leukocytes are blood cells that play a role in the immune mechanism. Leukocytes are classified based on the presence or absence of granules in the cytoplasm of leukocytes, which consist of granulocytes and agranulocytes. The normal leukocyte count is 3200-10000/mm3 of blood. If the leukocytes are above the normal limit, it is called leukocytosis. Leukocytosis can be pathological or physiological. Physiological leukocytosis that occurs during pregnancy is common due to two reasons, namely a physiological stress and an increased inflammatory response. Physiological stress arises as a response to changes that occur in the body of pregnant women, including the workload of the heart, digestive system, metabolism, thereby stimulating the production of white blood cells to increase immunity. The inflammatory response is a form of the body's selective immune tolerance, immunosuppression and immunomodulation of the fetus. The purpose of this study was to determine the relationship between gestational age and leukocyte count in pregnant women at the Slahung Health Center, Ponorogo Regency, which was conducted in July 2021. This study uses an analytical observational analytic method with a cross sectional approach. This research was conducted by examining gestational age and leukocyte count in pregnant women with a total sample of 30 samples and using a total sampling technique. Examination of the number of leukocytes using the Hematology Analyzer URIT 3000 Plus. The results based on the average number of leukocytes from this study in the first trimester were 3.20 x103/mm3, in the second trimester 8.42 x103/mm3, and in the third trimester 12.56 x103/mm3. The results of test using the Kruskal-Walis obtained a significance value of 0.000 < 0.05. The results of this study can be concluded that there is a relationship between gestational age and the number of leukocytes in pregnant women
HiTIC-Monthly: A High Spatial Resolution (1 km×1 km) Monthly Human Thermal Index Collection over China from 2003 to 2020
Authors: Zhang Hui , Luo Ming , Zhao Yongquan , Lin Lijie , Ge Erjia , Yang Yuanjian , Ning Guicai , Cong Jing , Zeng Zhaoliang , Gui Ke , Li Jing , Chen Ting On , Li Xiang , Wu Sijia , Wang Peng , Wang Xiaoyu
Published: August 2022

Abstract. Human thermal comfort measures the combined effects of temperature, humidity, and wind speed, etc., and can be aggravated under the influences of global warming and local human activities. With the most rapid urbanization and the largest population, China is being severely threatened by aggravating human thermal stress. However, the variations of thermal stress in China at a fine scale have not been fully understood. This gap is mainly due to the lack of a high-resolution gridded dataset of human thermal indices. Here, we generate the first high spatial resolution (1 km1 km) dataset of monthly human thermal index collection (HiTIC-Monthly) over China from 2003 to 2020. In this collection, 12 commonly used thermal indicators are generated by the LGBM machine learning algorithm from multi-source gridded data, including MODIS land surface temperature, topography, land cover and land use, population density, and impervious surface fraction. Their accuracies were comprehensively assessed based on observations at 2419 weather stations across the mainland of China. The results show that our dataset has desirable performance, with mean R2, root mean square error, mean absolute error, and bias of 0.996, 0.693 °C, 0.512 °C, and 0.003 °C, respectively, by averaging the 12 indicators. Moreover, the predictions exhibit high agreements with observations across spatial and temporal dimensions, demonstrating the broad applicability of our dataset. The comparison with two existing datasets also suggests that our high-resolution dataset can describe a more explicit spatial distribution of the thermal information, showing great potentials in fine-scale (e.g., intra-urban) study. Further investigation reveals that nearly all indicators exhibit increasing trends in most parts of China during the year 2003~2020. The increase is especially stronger in North China, Southwest China, the Tibetan Plateau, and parts of Northwest China, and in the spring and summer seasons. The HiTIC-Monthly dataset is publicly available via https://zenodo.org/record/6895533 (Zhang et al., 2022a).
Reprocessed 2-D airgun seismic reflection data SALTFLU (salt deformation and sub-salt fluid circulation in the Algero-Balearic abyssal plain) in the Balearic promontory and the Algerian basin
Authors: Blondel Simon , Ford Jonathan , Lockwood Aaron , Del Ben Anna , Camerlenghi Angelo
Published: August 2022

Abstract. In an ever more challenging context for the acquisition of seismic data in the Mediterranean Sea, reprocessing to improve the quality of legacy data has become increasingly important. This work presents the newly reprocessed, open access dataset SALTFLU acquired in the Algerian basin by the National Institute of Oceanography and Applied Geophysics (OGS) in 2012. We apply a ‘broadband’ reprocessing strategy adapted for short-offset, deep water airgun reflection seismic data and assess if the reprocessed images provide new geological insights on the Mediterranean sub-surface. The workflow relies on an integrated approach combining geophysics and geological interpretation to iteratively build the velocity model. In this way we aim to tackle some of the challenges linked to imaging complex geological structures containing high velocity contrasts with 2-D, short-offset seismic data. We first broaden the bandwidth of the data through multi-domain de-noising, deghosting and a source designature using an operator derived from the seabed reflection. We then perform iterative migration velocity analysis, pre-stack time migration and multiple attenuation in the Radon domain to obtain time-migrated images. The initial velocity model is derived from the resulting time migration velocities, and geologically driven model updates are generated using a combination of travel-time tomography, seismic interpretation of the major salt horizons and velocity gradient flooding. The gradient flooding aims to reproduce the large scale first-order velocity variations, while the travel-time tomography aims to resolve the smaller second-order velocity variations. The results improve our deep geological knowledge of the under-explored Algerian basin down to the base salt and the pre-salt. Fluid indicators are imaged within the Plio-Quaternary of the Algerian basin, which we interpret as thermogenic or biogenic gas sourced from either the Messinian Upper Unit or from the pre-salt, migrating through a hydro-fractured salt. The reprocessed data image lateral and vertical seismic facies variation within the Messinian units that could shed new light on the tectono-stratigraphic processes acting during the Messinian Salinity Crisis. It also reveals numerous previously unresolved volcanic structures within the Formentera basin.
Producing reliable hydrologic scenarios from raw climate model outputs without resorting to meteorological observations
Authors: Ricard Simon , Lucas-Picher Philippe , Thiboult Antoine , Anctil François
Published: August 2022

Abstract. A simplified hydroclimatic modelling workflow is proposed to quantify the impact of climate change on water discharge without resorting to meteorological observations. This alternative approach is designed by combining asynchronous hydroclimatic modelling and quantile perturbation applied to streamflow observations. Calibration is run by forcing hydrologic models with raw climate model outputs using an objective function that exclude the day-to-day temporal correlation between simulated and observed hydrographs. The resulting hydrologic scenarios provide useful and reliable information considering: (1) they preserve trends and physical consistency between simulated climate variables, (2) are implemented from a modelling cascade despite observation scarcity, and (3) support the participation of end-users in producing and interpreting climate change impacts on water resources. The proposed modelling workflow is implemented over four subcatchments of the Chaudière River, Canada, using 9 North American CORDEX simulations and a pool of lumped conceptual hydrologic models. Results confirm that the proposed workflow produces equivalent projections of the seasonal mean flows in comparison to a conventional hydroclimatic modelling approach. They also highlight the sensibility of the proposed workflow to strong biases affecting raw climate model outputs, frequently causing outlying projections of the hydrologic regime. Inappropriate forcing climate simulations were however successfully identified (and excluded) using the performance of the simulated hydrologic response as a ranking criterion. Results finally suggest further works should be conducted to confirm the reliability of the proposed workflow to assess the impact of climate change on extreme hydrologic events.
Laparoscopic Treatment of Benign Adnexal Masses During Pregnancy: A Comprehensive Evaluation of Treatment Basics, Efficacy and Surgical Techniques
Authors:   Department of Minimally Invasive Surgery Unit of Higueras Hospital and Clinica Andes Salud, Concepcion. University of Concepcion, Concepción, Chile, Smith Andres Vigueras , Aleksandrov Atanas ,   Department of Minimally Invasive Surgery Unit of Specialized Hospital for Obstetrics and Gynecology SBAGAL “Pr. Dimitar Stamatov” Varna Medical University, Varna, Bulgaria, Sumak Rok ,   Department of Minimally Invasive Surgery Unit of Centro Hospitalar Universitário do Porto, Porto, Portugal, Cabrera Ramiro ,   Department of Minimally Invasive Surgery, Angeles Clinic, DF, Mexico, Ferreira Helder ,   Department of Minimally Invasive Surgery Unit of Centro Hospitalar Universitário do Porto, Porto, Portugal
Published: August 2022

This review summarizes the evidence-based recommendations for how to approach and laparoscopically treat adnexal masses during pregnancy. We conducted a comprehensive review of studies related to the laparoscopic management of adnexal masses during pregnancy. Selected studies were independently reviewed by two authors. The overall incidence of ovarian tumors in pregnancy ranges between 0.05% and 5.7%, of which less than 5% are malignant. Diagnosis is based mainly on routine transvaginal ultrasound. More than 64% of simple cysts, less than 6 cm in diameter, will spontaneously resolve in less than 16 weeks. However, for persistent and complex tumors, the risk of acute complications can reach up to 9%. Surgical indications are similar to those in the non-gravidic setting, and include acute complications (torsion, rupture, hemorrhage), suspected malignancy and large (over 6 cm) persistent masses. Surgery must be scheduled between 16 and 20 weeks to allow for the spontaneous resolution of functional cysts. Furthermore, within that period, pregnancy becomes independent of the corpus luteum and enlargement of the uterus gives sufficient exposure for the surgery to be performed safely. A recent meta-analysis found that, compared to open surgery, laparoscopy is associated with significantly less preterm labor, blood loss and hospital stay, without differences in pregnancy loss or preterm birth rate. Since the main concerns about maternal-fetal safety are related to increased intraperitoneal pressure and the effects of hypercarbia (maternal hypertensive complications, fetal acidosis), a lower CO2 pressure (10 to 12 mmHg) and reduced operative times (less than 30 minutes) are recommended.
Fuzzy Bipolar Soft Quasi-ideals in Ordered Semigroups
Authors: Ul-Hakim Aziz- , Khan Hidayatullah , Ahmad Imtiaz , Khan Asghar
Published: August 2022

In this paper, we introduce the concept of fuzzy bipolar soft quasi-ideals in ordered semigroup theory. First some characteristics of the structure are examined and hence a few useful results are established. It is proved, among others, that the concepts of fuzzy bipolar soft bi-ideal and fuzzy bipolar soft quasi-ideal in regular ordered semigroups coincide. In addition, fuzzy bipolar soft quasi-ideals over ordered semigroups are linked with the ordinary quasi-ideals. Thereafter, a few classes of ordered semigroups are characterized in terms of their fuzzy bipolar soft left, fuzzy bipolar soft right and fuzzy bipolar soft quasi-ideals, and thus some important characterization theorems are established. We also define fuzzy bipolar soft semiprime quasi-ideals and characterize completely regular ordered semigroups by their fuzzy bipolar soft (semiprime) quasi-ideals.
It is proved that an ordered semigroup S is completely regular if and only
if every fuzzy bipolar soft quasi-ideal λA over S is a fuzzy bipolar soft
semiprime quasi-ideal.
A Study on the Occupational Stress Among the Radiographers Working in Healthcare Centres in Shillong
Authors: Kharjahrin Banari , Hrangkhawl Wilson
Published: August 2022

Background: Occupational stress can lead to negative impact on an individual which is associated with varying range of mental effects, resulting in Stress. Mainly due to increased workload, prolonged working hours and shifts duties, Healthcare workers (HCW) have been reported to have a great deal of stress. The aim of the study was to assess the occupational stress among the radiographers working in different healthcare settings in Shillong.
Methodology: This cross-sectional descriptive analytical study was performed on 25 Radiographers during pandemic in Shillong. Demographic information form and occupational Stress Questionnaire (HSE tool indicator) were used to collect data. The health and safety executive (HSE) questionnaire has 35 questions and 7 areas, which was developed in the 1990s by the UK Health and Safety Institute to measure occupational stress.
Results: The mean and SD score of job stress among Radiographers 134.5±21.38, the minimum and maximum score ranges from 89 to 163 respectively. The indicator analysis tool recommended 10 “psychosocial work conditions” that required improvement. On an aggregate level from the seven psychosocial working conditions ‘Control’ and ‘Managers support’ category warranted improvement.
Conclusions: The mean stress score among the participants of the present the study has shown the main source of stress being Managers support, followed by control, relationship conflicts among co- workers, excess demand, and lack of peer support. Hence, it is recommended to develop interventions needed to manage psychosocial stress that may result in an improved work efficiency.

Key words: Occupational Stress, Radiographers, Medical Imaging Technologist, Healthcare workers, Stressors .
Vietnam - Japan Economic Partnership Agreement (VJEPA) in Bilateral Foreign Economic Relations Between Vietnam and Japan
Authors: Phong Nguyen Quoc
Published: August 2022

Vietnam - Japan Economic Partnership Agreement (VJEPA) is the first bilateral free trade agreement (FTA) of Vietnam after the country joined the World Trade Organization (WTO). The article outlines the main trade and investment commitments of the agreement. The implementation of the VJEPA has promoted the flow of goods from Vietnam to Japan, and at the same time has attracted FDI capital from Japan. The role of VJEPA is confirmed as a catalyst to promote bilateral foreign economic relations between Vietnam and Japan in the article.

Keywords: VJEPA, agreement, international trade, FDI.
G-POEM for severe and refractory gastroparesis
Authors: Liu Joy , Aadam Abdul Aziz , Amin Sunil , Mamood Sultan
Published: August 2022

Gastroparesis is characterized by nausea, vomiting, abdominal pain and delayed gastric emptying. This chronic condition has few effective medical options. Gastric peroral endoscopic myotomy (G-POEM) is an emerging alternative to surgical pyloroplasty or pyloromyotomy that may provide relief in carefully selected patients with severe symptoms. This article summarizes the @GIJournal Twitter discussion of Martinek et al, “Endoscopic pyloromyotomy for the treatment of severe and refractory gastroparesis: a pilot, randomised, sham-controlled trial,” originally published in Gut. In this study of 40 patients, G-POEM was associated with significant improvement in symptoms and quality of life at 6 months, including patients who crossed over from sham, and especially in those with diabetic gastroparesis. Future studies will provide data on longer follow-up periods and examine strategies for G-POEM candidate selection.
Identifying Suitable Solid Waste Landfill Sites Using Spatial Multi-Criteria Decision Analysis
Authors: Hina Syeda Mahlaqa , Szmerekovsky Joseph , Lee EunSu , Amin Muhammad , Arooj Syeda
Published: August 2022

The required skill sets for dealing with solid waste management are lacking in developing countries. Further, this issue is compounded by the rapid growth of waste generation in those countries. This study helps to address this problem by performing a landfill site selection for the
Twin Cities of Pakistan. The study uses a multi-criteria decision model for siting a suitable landfill utilizing Geographic Information Systems (GIS). The use of geospatial technology provides network-based spatial analysis and assists in modeling practical network situations. In particular,
this analysis accounts for proximity to urban/residential areas, road networks, water streams, and water reservoirs/lakes. It also accounts for land slope and land use/land cover. The results indicate that 96.3% of the Twin Cities area is unsuitable, 1.6% is moderately suitable, and 2.1% is
most suitable. The results of the study identify appropriate sites for more detailed analysis based on current and future land use, population growth, and waste generation. As similar challenges of handling solid waste are common in developing countries, this study can serve as a guide in
other developing countries.
Assessment of the Correlation Between Vitamin D and T3, T4, FT3, FT4 and TSH Among Patients with Graves' Disease
Authors: Mohammed Ali Angham Jasim , Hamoud Majedaldeen Jumaa Majeed
Published: August 2022

Background: Graves' disease is characterized by a diffuse hyperfunctional goiter that develops suddenly and is linked to an immune thyroid stimulating factor. Graves' disease hyperthyroidism is caused by circulating IgG antibodies binding to and activating the G-protein–coupled thyrotropin receptor. This activation causes thyroid enlargement by stimulating follicular hypertrophy and hyperplasia, as well as increases in thyroid hormone synthesis. Objectives: This study aims to assess the Determination the concentration of vitamin D in patients with graves diseases, Measurement T3, T4, FT3, FT4 and TSH hormones and Determination the correlation between immunological markers by the (SPSS). Materials and Methods: This research included a total of (90) people of various sexes and ages (30 men and 60 females), including (60) Graves' disease patients and (30) healthy people. Patients with Graves' disease were seen at Alsader Medical City (Najaf Center for Diabetes and Endocrinology). Between November 2021 and January 2022. Results: In this research, the levels of (T3, T4, TSH, FT3 and FT4) hormones and Vitamin D revealed a very significant association (P.value> 0.005) across the groups tested. A non-significant association was also found between vitamin D and other variables. According to the patients' group, the FT3 revealed a strong negative connection with vitamin D in comparison to the other parameters. Conclusion: The Thyrotropin receptor antibody (TRAb) test and ultrasonography of the thyroid gland are useful diagnostic tools for autoimmune Graves' disease. Grave's disease is connected with decreased vitamin D levels in the blood and could be made worse by high serum levels of T3, T4, FT3, FT4, and TRAb-positive and a low serum level of TSH.
Dentists Knowledge about Association of Systemic Health with Periodontal Disease
Authors: Feroze Hafsa , Zaidi Syed Akbar Abbas , Shaik Waheed Gul , Tanveer Talha , Ali Misbah , Aslam Mehmil
Published: August 2022

Purpose: This study designed to evaluate the necessity for interdisciplinary dental and medical education by assessing clinicians' awareness of the relation between systemic health and periodontal disease. Study design: A Cross-sectional and Descriptive study. Place and Duration: In the Dental department of Hamdard University Dental Hospital, Karachi for six-months duration from July 2021 to December 2021. Methods: A sample of 200 dentists and physicians was designated using convenient technique of sampling. A self- validated and pre-validated questionnaire consisting of questions about the knowledge of the relationship between systemic health and periodontal disease among dentist was used. Data was analyzed using SPSS 24.0. Results: While 184 out of 200 dentists agreed that there was a link between periodontal disease and systemic health, 16 disagreed. Most (194) participants were aware of the periodontal disease and its associated signs and symptoms, and (6) were unaware of these symptoms. While most dentists (172) considered bleeding from the gingiva to be the major symptom clinically of periodontal disease, 102 dentists reported gingival pain as the primary symptom. In addition, most dentists (185) have stated that they have awareness about the relation between periodontal disease and diabetes, while 172 dentists have stated that cardiovascular disease and obesity are associated with periodontal disease Conclusion: The information on the association between systemic health with periodontal disease among practitioners was satisfactory. Keywords: Diabetes, cardiovascular diseases, obesity, gingival bleeding, systemic health and periodontal disease
The Causes and Complications of Urinary Retention in Adult Males Managed at Pakistan Institute of Medical Sciences Islamabad Pakistan
Authors: Siraj Shahid , Saleem Amjad , Hassan Raza Ul , Khan Ajmal , Ahmad Iftikhar , Naeem Raja
Published: August 2022

Background: urinary retention is characterized as body inability to empty the bladder completely by voluntary micturition. The UR is highly observed in the male adult. But the limited and sufficient knowledge is present about its causes and associated complication. Objective: It is most common urological emergency in hospitals. The study aimed to evaluate the causes and associated complications of urinary retention. Material and Methods: This prospective hospital based study was conducted on 176 patients visited the emergency department of Pakistan Institute of Medical Sciences Islamabad over a period of 06 months. The review board and ethical committee of the hospital approved the study. Informed consent was taken from all patients included in study. A brief history and examination was done to establish the diagnosis. Urinary retention was relived either by per urethral or supra-pubic cathrterization followed by detailed history, examination and investigations. The urine sample of each patient was taken for urinalysis. Baseline investigations were done on every patients. Depending on the clinical impression the investigations were individualized. The results were retrieved from the collected data. The data was statistically analyzed by using SPSS software. Results: 176 patients were recruited during this research time. The patients mean age was 58.81±17.36SD. The maximum number of patients encountered in age group of 55-74years. Most common cause of urinary retention was enlarge prostate 67.04%, followed by urethral stricture 18.75% and impacted urethral/Urinary bladder stone 14.20%. Acute urinary retention was diagnosed in 62.50% while 37.50% were diagnosed as chronic urinary retention. The 65.34% patients were treated with per urethral catheterization and 34.66% were treated with supra-pubic catheterization. In 62.50% patients no complication were observed while in other 19.88% were diagnosed with urinary tract infection and 17.62% with the renal insufficiency. Conclusion: Urinary retention is common in adult patients. Enlarge prostate was the one of the main cause of urinary retention. The most common type of retention was acute urinary retention. Complications were mostly associated with chronic urinary retention. Keywords: Urinary retention, Complications, adult male, Enlarge Prostate and acute urinary retention.
Acute respiratory distress syndrome secondary to COVID-19 mRNA vaccine administration in a pregnant woman: A case report
Authors: Abraham Betsy , Mohammed Saeed Hassan , Azeez Pasha S. A.
Published: August 2022

Healthcare professionals monitoring vaccine-related adverse responses should be aware of COVID-19 vaccine-related acute respiratory distress syndrome to enable expeditious diagnosis and treatment. We report the first case of acute respiratory distress syndrome in a young pregnant woman, occurring immediately after a second dose of the Pfizer-BioNTech BNT16B2b2 mRNA COVID-19 vaccine and requiring a brief period of mechanical ventilation, with a good response to a two-week steroid course. She had recovered from mild COVID-19 infection requiring home isolation nine months prior to the current vaccination dose. Without depreciating the colossal benefit of the COVID-19 vaccine, vaccine-related acute respiratory distress syndrome should be listed as a possible adverse reaction.
EMERGÊNCIA E RESSURGIMENTO DE DOENÇAS INFECCIOSAS: OS DESAFIOS DAS FRONTEIRAS SANITÁRIAS
Authors: SARTOR Elisiane De Bona , MIGUEL Isadora Dallarmi , Dos ANJOS Cíntia , DIAS Josiane De Fátima Gaspari , MIGUEL Obdulio Gomes , MIGUEL Marilis Dallarmi
Published: August 2022

O processo de globalização, o aumento do trânsito internacional de pessoas e mercadorias e a mudança contínua da situação epidemiológica mundial, trouxeram como consequência, o aumento da porosidade das fronteiras dos países para a entrada de doenças infecciosas emergentes e reemergentes. Esse estudo realizou uma revisão da importância das fronteiras sanitárias e suas particularidades, no contexto das doenças infectocontagiosas. Recentemente, além da COVID-19, a varíola do macaco, identificada em diversos países de forma simultânea, estão no centro das atenções da OMS. Além disso, crises humanitárias complexas ocorrem em diversos países, com uma convergência de doenças, seca, fome e guerra, alimentadas pelas mudanças climáticas, desigualdade e rivalidade geopolítica, criam um cenário global de difícil controle. A integração dos sistemas de saúde de países fronteiriços, a consolidação de redes de saúde assistencial organizadas e a capacitação das redes diagnósticas, qualificadas em responder rapidamente a possíveis eventos de risco em saúde, são aspectos importantes para o fortalecimento da saúde global