bluuebunny/crossref_metadata_2025 huggingface dataset:
Metaphorization of Nature in Anna Akhmatova's Lyric Poetry
Authors: Poliakova Anna Nikolaevna
Published: September 2020

The primary goal of this paper is to study of the features of the linguistic representation of nature-related vocabulary in Anna Akhmatova’s lyric poems. The principles of compiling a frequency list of plant names are described, a classification of floristic vocabulary is given, and the lexical and semantic subgroup ‘trees’ is analyzed in detail. The specific features of the poet’s individual vision of floristic vocabulary are revealed, taking into account the author’s imagery explicating plant nominations in the literary text.
Semantic Peculiarities of Lacunae – Modifications. The Concept of Lacunae Dictionary Creation (A Case Study of Russian Verbs of Sound)
Authors: Ivlieva Irina Valentinovna
Published: September 2020

The article examines the insufficiently explored phenomenon in word-formation synthesis – the intra-linguistic affixal lacunae i.e. lexical gaps. The nature of lacunar units is described as a unique type of semantic modifications that display a similar structure, semantics, and characteristics. From the standpoint of derivative codification, the major lacunae groups are identified, analyzed, and mapped out based on their lexicographic properties. The glossary selection criteria for the experimental Lacunae – Modifications Dictionary are determined. Relying on the data from the Russian National Corpus, nearly 5,000 lacunae and sound verb modifications, combined, were researched using a web-scraping algorithm from a special project at Missouri S&T. The results of this study may serve as a foundational platform for this novel dictionary of affixal lexical gaps in the Russian language.
Oppositional Defiant Disorder in Childhood and Adolescence
Authors: Dubatova Irina Vladimirovna , Antsyborov Andrey Viktorovich , Kalinchuk Anna Valerievna , Antsyborov Lema Andreevich
Published: September 2020

Oppositional defiant disorder (ODD) and conduct disorder (CD), which usually develop at the age below 18, are considered as a sustainable antisocial and aggressive types of behavior, stepping beyond the borders of socially accepted standards. Within the recent decades, significant success has been achieved in the diagnosis and long-term predictive assessment of different types of behavioral aberrations, occurring during the childhood and adolescence. Early development of behavioral disorders forms unfavorable predictions and correlates with biological and social risk factors, such as attention deficit, impulse control disorder and unfavorable social environment. Most of the clinical observations confirm the effectiveness of different psychotherapeutic programs in the therapy of ODD/CD. The drug treatment is proposed to be used only in the severe cases, or in the cases when psychotherapeutic methods are not effective.
Assessment of the Non-Financial Reporting Indicators Influence on the Company’s Investment Attraction
Authors: Bunina Viktoriia Nikolaevna
Published: September 2020

This article considers social reporting as a new phenomenon for Russian companies. The relevance of the topic is determined by the growing interest in environmental and social activities of companies from stakeholders and at the level of government initiatives. Russian business representatives are aware of the importance of presenting non-financial information, but only some of them publish social reporting now. This is due to a lack of understanding of the methodology, the complexity of the quality criteria for the report, and the laborious process of forming. Therefore, questions of existing standards and techniques, as well as the assessment of the report’s impact on the investment attractiveness of the company are particularly important. In this research paper, the trends in the influence of information on potential investors are identified. The authors propose a reporting methodology based on GRI for companies planning to switch to non-financial reporting.
Edible Mushrooms: Novel Medicinal Agents to Combat Metabolic Syndrome and Associated Diseases
Authors: Tung Yu-Tang , Pan Chun-Hsu , Chien Yi-Wen , Huang Hui-Yu
Published: September 2020

Metabolic syndrome is an aggregation of conditions and associated with an increased risk of developing
diabetes, obesity and cardiovascular diseases (CVD). Edible mushrooms are widely consumed in many countries
and are valuable components of the diet because of their attractive taste, aroma, and nutritional value. Medicinal
mushrooms are higher fungi with additional nutraceutical attributes having low-fat content and a transisomer
of unsaturated fatty acids along with high fiber content, biologically active compounds such as polysaccharides
or polysaccharide β-glucans, alkaloids, steroids, polyphenols and terpenoids. In vitro experiments, animal
models, and even human studies have demonstrated not only fresh edible mushroom but also mushroom
extract that has great therapeutic applications in human health as they possess many properties such as antiobesity,
cardioprotective and anti-diabetic effect. They are considered as the unmatched source of healthy foods
and drugs. The focus of this report was to provide a concise and complete review of the novel medicinal properties
of fresh or dry mushroom and extracts, fruiting body or mycelium and its extracts, fiber, polysaccharides,
beta-glucan, triterpenes, fucoidan, ergothioneine from edible mushrooms that may help to prevent or treat metabolic
syndrome and associated diseases.
Methods for Evaluating Sensory, Affective and Cognitive Disorders in Neuropathic Rodents
Authors: Palazzo Enza , Marabese Ida , Gargano Francesca , Guida Francesca , Belardo Carmela , Maione Sabatino
Published: September 2020

The animal models of neuropathic pain that faithfully reproduce the symptoms that occur
in humans are a fundamental tool for understanding the mechanisms underlying the disease,
identifying new targets, and developing effective drugs. So far, the studies aimed at describing the
animal models of neuropathic pain have been focused mainly on the sensory symptoms associated
with the disease consisting of mechanical allodynia and hyperalgesia, cold allodynia and hyperalgesia,
and heat hyperalgesia. However, affective and cognitive comorbidities occur in patients suffering
from neuropathic pain, arising in a closely associated and dependent manner on the sensory
symptoms. The same occurs in animal models of neuropathic pain in which anxiety- and depressive-
like behaviors and cognitive disorders are observable at different time points from the induction
of neuropathy. Today there are several tests available that exploit different paradigms in rodents
for measuring sensorial, affective, and cognitive behavior. This review will describe those
mainly used in the scientific community. The tests mainly used are based on the motor activity of
the animals tested, so it is fundamental that it remains unaffected in the model used for inducing
neuropathic pain. We hope that this review will be useful to the scientific community to direct the
choice towards the best, most suitable, and simplest tests for the study of the sensory, affective, and
cognitive symptoms associated with neuropathic pain.
Drug Delivery Nanosystems in Glioblastoma Multiforme Treatment: Current State of the Art
Authors: Di Filippo Leonardo Delello , Duarte Jonatas Lobato , Luiz Marcela Tavares , de Araújo Jennifer Thayanne Cavalcante , Chorilli Marlus
Published: September 2020

Glioblastoma multiforme (GBM) is the most common primary malignant Central Nervous
System cancer, responsible for about 4% of all deaths associated with neoplasia, characterized
as one of the fatal human cancers. Tumor resection does not possess curative character, thereby
radio and/or chemotherapy are often necessary for the treatment of GBM. However, drugs used
in GBM chemotherapy present some limitations, such as side effects associated with non-specific
drug biodistribution as well as limited bioavailability, which limits their clinical use. To attenuate
the systemic toxicity and overcome the poor bioavailability, a very attractive approach is drug encapsulation
in drug delivery nanosystems. The main focus of this review is to explore the actual
cancer global problem, enunciate barriers to overcome in the pharmacological treatment of GBM,
as well as the most updated drug delivery nanosystems for GBM treatment and how they influence
biopharmaceutical properties of anti-GBM drugs. The discussion will approach lipid-based and polymeric
nanosystems, as well as inorganic nanoparticles, regarding their technical aspects as well
as biological effects in GBM treatment. Furthermore, the current state of the art, challenges to overcome
and future perspectives in GBM treatment will be discussed.
A Review on Phytopharmaceuticals having Concomitant Experimental Anti-diabetic and Anti-cancer Effects as Potential Sources for Targeted Therapies Against Insulin-mediated Breast Cancer Cell Invasion and Migration
Authors: Singh Vibhavana , Reddy Rakesh , Sinha Antarip , Marturi Venkatesh , Panditharadyula Shravani S. , Bala Asis
Published: September 2020

Diabetes and breast cancer are pathophysiologically similar and clinically established diseases that co-exist with a wider complex similar molecular signalling and having a similar set of risk factors. Insulin plays a pivotal role in the invasion and migration of breast cancer cells. Several ethnopharmacological evidences shed light on the concomitant anti-diabetic and anti-cancer activity of medicinal plant and phytochemicals against breast tumors of patients with diabetes. This present article reviewed the findings on medicinal plants and phytochemicals with concomitant antidiabetic and anti-cancer effects reported in scientific literature to facilitate the development of dual- acting therapies against diabetes and breast cancer. The schematic tabular form of published literature on medicinal plants (63 plants belongs to 45 families) concluded the dynamics of phytochemicals against diabetes and breast tumors that could be explored further for the discovery of therapies for controlling of breast cancer cell invasion and migration in patients with diabetes.
Characterization of Dopamine Receptor Associated Drugs on the Proliferation and Apoptosis of Prostate Cancer Cell Lines
Authors: Akbarian Fatemeh , Dadkhah Farid , Campbell Arezoo , Asadi Farrokh , Ahangari Ghasem
Published: September 2020

Background:

Dopamine receptor (DR) gene family play an essential role in the regulation of interleukin-6 (IL-6) production. Our prior analysis of human prostate biopsy samples demonstrated the increased expression of IL-6 and a down regulating trend for dopamine receptor gene family.

Objective:

The objective was to investigate the expression of dopamine receptors, their catabolizing enzyme and IL-6 in prostate cancer cell lines and assess pharmacological effect of dopamine receptor modulators as a novel class of drugs repurposed for treatment of prostate cancer.

Methods:

The therapeutic effect of dopamine, DR agonists, and DR antagonist were examined using LNCaP and PC3 cell lines.CellviabilityandproliferationwereassessedbyMTTassayandproliferatingcellnuclearantigenexpressionanalysis, respectively. Furthermore, bax/bcl2 ratio, immunofluorescence assay and flow cytometric assay were performed for apoptosis analysis. RT-q PCR analysis was used to characterize relative expression of dopamine-related genes, catabolic enzyme catechol-o-methyl-transferase (COMT) and IL-6 before and after treatment to assess the therapeutic effects of drugs.

Results:

LNCaP cells express DRD1, DRD2, DRD5 and COMT genes and PC3 cells only express IL-6 gene. In-vitro, dopamine receptor agonists reduced cell viability of LNCaP and PC3 cells. In contrast, dopamine and dopamine receptor antagonist significantly increased tumor growth in PC3 cells.

Conclusion:

Our results offer novel suggestion for a pathogenic role of dopamine receptor signaling in prostate cancer adenocarcinoma and indicates that modulators of DR-IL-6 pathway, including FDA-approved drug bromocriptine, might be utilized as novel drug repurposing strategy.
Minocycline Inhibits mTOR Signaling Activation and Alleviates Behavioral Deficits in the Wistar Rats with Acute Ischemia stroke
Authors: Wang Shengyuan , Wang Chuanling , Wang Lihua , Cai Zhiyou
Published: September 2020

Background:

Mammalian target of rapamycin (mTOR) has been evidenced as a multimodal
therapy in the pathophysiological process of Acute Ischemic Stroke (AIS). However, the
pathway that minocycline targets mTOR signaling is not fully defined in the AIS pathogenesis.
This study aims at the roles of minocycline on the mTOR signaling in the AIS process and further
discovers the underlying mechanisms of minocycline involved in the following change of mTOR
signaling-autophagy.

Methods:

Cerebral ischemia/reperfusion (CIR) rat animal models were established with the transient
suture occlusion into the middle cerebral artery. Minocycline (50mg/kg) was given by intragastric
administration. The Morris water maze was used to test the cognitive function of animals.
Immunohistochemistry and immunofluorescence were introduced for testing the levels of synaptophysin
and PSD-95. Western blot was conducted for investigating the levels of mTOR, p-mTOR
(Ser2448), p70S6, p-p70S6 (Thr389), eEF2k, p-eEF2k (Ser366), p-eIF4B (Ser406), LC3, p62, synaptophysin
and PSD-95.

Results:

Minocycline prevents the cognitive decline of the MCAO stroke rats. Minocycline limits
the expression of p-mTOR (Ser2448) and the downstream targets of mTOR [p70S6, p-p70S6
(Thr389), eEF2k, p-eEF2k (Ser366) and p-eIF4B (Ser406)] (P<0.01), while minocycline has no influence
on mTOR. LC3-II abundance and the LC3-II/I ratio were upregulated in the hippocampus
of the MCAO stroke rats by the minocycline therapy (P<0.01). p62 was downregulated in the hippocampus
from the MCAO stroke rats administrated with minocycline therapy(P<0.01). The levels
of SYP and PSD-95 were upregulated in the brain of the MCAO stroke rats administrated with
minocycline therapy.

Conclusion:

Minocycline prevents cognitive deficits via inhibiting mTOR signaling and enhancing
the autophagy process, and promoting the expression of pre- and postsynaptic proteins (synaptophysin
and PSD-95) in the brain of the MCAO stroke rats. The potential neuroprotective role of
minocycline in the process of cerebral ischemia may be related to mitigating ischemia-induced synapse
injury via inhibiting the activation of mTOR signaling.
Task Scheduling in Cloud Using ACO
Authors: Natarajan Yuvaraj , Kannan Srihari , Dhiman Gaurav
Published: September 2020

Background:

Cloud computing is a multi-tenant model for computation that offers various features for
computing and storage based on user demand. With increasing cloud users, the usage increases that highlights the problem
of load balancing with limited resource availability based on dynamic cloud environment. In such cases, task scheduling
creates fundamental issue in cloud environment.

Introduction:

Certain problems such as, inefficiencies in load balancing latency, throughput ratio, proper utilization of the
cloud resources, better energy consumption and response time have been observed. These drawbacks can be efficiently
resolved through the incorporation of efficient load balancing and task scheduling strategies.

Method:

In this paper, we develop an efficient co-operative method to solve the most recent approaches against load
balancing and task scheduling have been proposed using Ant Colony Optimization (ACO). These approaches enables in
the clear cut identification of the problems associated with the load balancing and task scheduling strategies in the cloud
environment.

Results:

The simulation is conducted to find the efficacy of the improved ACO system for load balancing in cloud than
the other methods. The result shows that the proposed method obtains reduced execution time, reduced cost and delay.

Conclusion:

A unique strategic approach is developed in this paper, Load Balancing, which works with the ACO in
relation to the cloud workload balancing task through the incorporation of the ACO technique. The strategy for
determining the applicant nodes is based on which the load balancing approach would essentially depend. By
incorporating two different approaches: the maximum minute rules and the forward-backward ant, this reliability task can
be established. This method is intended to articulate the initialization of the pheromone and thus upgrade the relevant
cloud-based physical properties.
Wireless Sensor Network in IoT and Performance Optimization
Authors: Gupta Sunita , Gupta Sakar , Goyal Dinesh
Published: September 2020

:

A serious problem in Wireless Sensor Networks (WSNs) is to attain high-energy efficiency as battery is used to
power and have limited stored energy. They can’t be suitably replaced or recharged. Appearance of renewable energy
harvesting techniques and their combination with sensor devices gives Energy Harvesting Wireless Sensor Networks
(EHWSNs). IoT is now becoming part of our lives, comforting simplifying our routines and work life. IoT is very popular
. It connects together, computes, communicates and performs the required task. IoT is actually a network of physical
devices or things that can interact with each other to share information. This paper gives an overview of WSN and IoT,
related work, different ways of connecting WSN with internet, development of smart home, challenges for WSN etc. Next
a Framework for performance optimization in IoT is given and QC-PC-MCSC heuristic is analyzed in terms of Energy
Efficiency and Life Time of a sensor on Energy Latency Density Design Space, a topology management application that
is power efficient. QC-PC-MCSC and QC-MCSC are compared for Energy Efficiency and Life Time of a sensor over
energy latency density design space, a topology management application.
Comparación de la disponibilidad de hongos comestibles en tierras altas y bajas de Chiapas y sus implicaciones en las estrategias tradicionales de aprovechamiento
Authors: Ruan-Soto Felipe , Cifuentes Blanco Joaquín , Garibay Orijel Roberto , Caballero Nieto Javier
Published: September 2020

Antecedentes y Objetivos: Las estrategias tradicionales de aprovechamiento de hongos silvestres comestibles han sido descritas de tierras altas y bajas en México. No obstante, al parecer en las tierras bajas el aprovechamiento de especies es menor que en las altas. La etnomicología ecológica se interesa en comprender cómo ciertos patrones ecológicos en los hongos pueden orientar las estrategias tradicionales de aprovechamiento. Este estudio presenta una comparación entre la disponibilidad de esporomas de hongos comestibles en dos condiciones ecológicas, Los Altos de Chiapas y la Selva Lacandona. Se plantea la hipótesis de que la disponibilidad de esporomas es mayor tanto en tierras altas como en sitios con vegetación conservada y, por tanto, esto podría explicar un mayor beneficio en dicho piso ecológico y el aprovechamiento oportunista en tierras bajas. Métodos: Durante 2009 y 2010 se monitoreó la abundancia, biomasa, frecuencia espacial y temporal como indicadores de disponibilidad, en transectos rectangulares en tres localidades de cada piso en Chiapas, México, en vegetación conservada y agroecosistemas. Resultados clave: En tierras altas existió una mayor riqueza (35 etnotaxones) y una mayor producción de biomasa (12,345.2 g), mientras que en tierras bajas se registró una mayor abundancia de esporomas (3212), frecuencia espacial (76.6%) y temporal (40%).Conclusiones: En ambos pisos ecológicos existe disponibilidad del recurso que permite su aprovechamiento; sin embargo, este se comporta diferente en términos ecológicos. Esto puede explicar porque en tierras altas las personas utilizan una mayor cantidad de especies y la preferencia por aquellas de mayor biomasa. Por el contrario, en tierras bajas se aprovecha un menor número de especies, pero más abundantes, y con mayor presencia espacial y temporal. Los datos aquí presentados muestran que las tierras bajas y los agroecosistemas son espacios con una disponibilidad de hongos tan importante como la de los bosques de tierras altas.
Lateralni retinakul
Authors: Gulan Gordan , Gržalja Nikola , Lalić Strahimir , Gulan Leo
Published: September 2020

Povećana napetost lateralnog retinakula patele može se javiti kao samostalni entitet ili u sklopu drugih poremećaja patelofemoralnog zgloba kao što su patelofemoralna displazija, lateralna nestabilnost patele, ozljede medijalnog patelofemoralnog ligamenta i hondromalacija. Presijecanje lateralnog retinakula, kako bi se postigao bolji balans aktivnih i pasivnih stabilizatora patele i na taj način korigirao njen položaj, bila je jedna od najizvođenijih operacija u ortopediji bez obzira na etiologiju poremećaja. Biomehaničke i kliničke analize pokazale su mogućnost nastanka brojnih komplikacija koje mogu nastati neselektivnom primjenom ove operacijske tehnike od kojih je najteža medijalna nestabilnost patele. Danas se kao metoda za korigiranje napetosti lateralnih stabilizatora patele češće upotrebljava tehnika produljivanja lateralnog retinakula kojom se puno bolje može regulirati napetost lateralnih struktura uz značajno manje komplikacija.
Tetiva mišića plantarisa – novi presadak i operacijska tehnika zajedničke rekonstrukcije prednjeg križnog i anterolateralnog ligamenta koljena
Authors: Vlaić Josip , Jelić Mislav , Schauperl Zdravko , Nizić Dinko , Šimunović Marko , Serdar Jure , Josipović Mario
Published: September 2020

Mišić plantaris je mali mišić površnog stražnjeg odjeljka noge karakteriziran najdužom tetivom u ljudskom tijelu. Istraživanja ukazuju da je plantaris rudimentarni mišić sa zanemarivom biomehaničkom funkcijom. Tetiva mišića plantarisa odavno je prepoznata kao lako dostupan presadak kod raznih rekonstruktivnih zahvata u ortopediji. Anterolateralni ligament koljena predstavlja važan čimbenik uspostave rotacijske stabilnosti kod koljena kojem nedostaje funkcija prednjeg križnog ligamenta. Tetiva mišića plantarisa ima odlična biomehanička svojstva za rekonstrukciju anterolateralnog ligamenta. U ovom kratkom preglednom radu prikazana je nova operacijska tehnika zajedničke rekonstrukcije prednjeg križnog ligamenta i anterolateralnog ligamenta koljena uz presatke tetiva mišića semitendinozusa i plantarisa.
Nitrogen Requirement of Potato for Eastern Indo-Gangatic Plain of India
Authors: YADAV S. K. , SINGH R. K. , DUA V. K. , SINGH S , YADAV SARALA , BAKADE RAHUL  R.
Published: September 2020

A field experiment was carried out during 2015-16 and 2016-17 at ICAR-Central Potato Research Station, Patna, Bihar, in randomized block design with four replications with objective to quantity the optimum requirement of nitrogen to potato crop. Significantly the highest plant height was recorded with nitrogen level of 300 kg/ha. Distributions of the smallest size of tuber yield of potato were decreasing with increasing the level of nitrogen. There was about 26.0% more yield of the smallest size tuber of potato was recorded with zero nitrogen as compare to the highest level of nitrogen i.e. 300 kg/ha. Increasing the nitrogen over the level of 150 to 225 kg per hectare, increasing the yield of tuber gradually slower rate than nitrogen level from 0 to 150 kg/ha. Total and marketable tuber yield of potato were increasing significantly with increasing level of nitrogen up to 150 kg/ha. There was no significant difference in marketable tuber yield was found for nitrogen level between 150 and 225 kg/ha. Highest (1.66) net benefit cost ratio was also recorded with level of nitrogen @ 150 kg/ha in potato. Hence, application of nitrogen @ 150 kg/ha was found statistically and economically more beneficial for potato cultivation in Eastern Indo-Gangatic plain of India.
Analysis of Socio-economic Status of People in aspirational districts of Odisha for Inclusive growth
Authors: KUMAR ANIL , JEEVA J. C. , SARANGI D. N. , PANDA A. K. , SRIVASTAVA S. K.
Published: September 2020

Aspirational district programme was launched by the government of India to uplift the 117 backward districts in the country through rapid development. Ten districts of Odisha were included in this programme which included Dhenkanal, Gajapati, Kandhamal, Balangir, Kalahandi, Rayagada, Koraput, Malkangiri, Nuapada and Nabarangpur. Socio-economic variables formed important dimension for identifying the backwardness of districts. Hence, the socio-economic status of people in the 101 blocks in the ten backward districts were analyzed to address the weak points. The socio-economic indicators analyzed were: population density, sex ratio, SC and ST population, total literacy percent, male and female literacy percent, and gender gap in literacy percent and they were compared with the state average. Most of the aspirational districts are located in the southern part of Odisha except Dhenkanal. In the aspirational districts 89.3 percent of the population live in rural areas compared to 83.3 percent for state average. These aspirational districts have high tribal population (39.4 percent) with lower human density (153 per sq km), higher sex ratio (1010), low total literacy (58.1 percent), low female literacy (47.1 percent) and high gender gap in literacy (22.2 percent). The 101 blocks in the aspirational districts of Odisha were also ranked based on these indictors. The study revealed that the socio-economic indicators in the aspirational districts were weak which need focused attention for their improvement.
The Relation Between Official WhatsApp-Distributed COVID-19 News Exposure and Psychological Symptoms: Cross-Sectional Survey Study
Authors: Liu Jean C J , Tong Eddie M W
Published: September 2020

Background

In a global pandemic, digital technology offers innovative methods to disseminate public health messages. As an example, the messenger app WhatsApp was adopted by both the World Health Organization and government agencies to provide updates on the coronavirus disease (COVID-19). During a time when rumors and excessive news threaten psychological well-being, these services allow for rapid transmission of information and may boost resilience.

Objective

In this study, we sought to accomplish the following: (1) assess well-being during the pandemic; (2) replicate prior findings linking exposure to COVID-19 news with psychological distress; and (3) examine whether subscription to an official WhatsApp channel can mitigate this risk.

Methods

Across 8 weeks of the COVID-19 outbreak (March 7 to April 21, 2020), we conducted a survey of 1145 adults in Singapore. As the primary outcome measure, participants completed the Depression, Anxiety, and Stress Scale (DASS-21). As predictor variables, participants also answered questions pertaining to the following: (1) their exposure to COVID-19 news; (2) their use of the Singapore government’s WhatsApp channel; and (3) their demographics.

Results

Within the sample, 7.9% of participants had severe or extremely severe symptoms on at least one DASS-21 subscale. Depression scores were associated with increased time spent receiving COVID-19 updates, whereas use of the official WhatsApp channel emerged as a protective factor (b=–0.07, t[863]=–2.04, P=.04). Similarly, increased anxiety scores were associated with increased exposure to both updates and rumors, but this risk was mitigated by trust in the government’s WhatsApp messages (b=–0.05, t[863]=–2.13, P=.03). Finally, although stress symptoms increased with the amount of time spent receiving updates, these symptoms were not significantly related to WhatsApp use.

Conclusions

Our findings suggest that messenger apps may be an effective medium for disseminating pandemic-related information, allowing official agencies to reach a broad sector of the population rapidly. In turn, this use may promote public well-being amid an “infodemic.”

Trial Registration

ClinicalTrials.gov NCT04305574; https://clinicaltrials.gov/ct2/show/NCT04305574
Spatial Epidemiological Analysis and Geographical Information System of Opioid Overdoses in New York State (Preprint)
Authors: Pengput Anuwat , Elkin Peter
Published: September 2020

BACKGROUND

Opioid analgesics are pain relievers. There are no better drugs than opioids for treating severe pain, however, opioids are the main drugs associated with overdose deaths.

OBJECTIVE

The study aimed to identify the distribution and clusters of opioid overdoses across New York.

METHODS

We used the deidentified hospital inpatient discharges datasets (SPARCS) from 2010 – 2015. ICD 9 and ICD 10 codes were used to identify and retrieve opioid overdose patients. We merged and aggregated SPARCS datasets to a geographic shapefile by all counties in New York.

RESULTS

More than half of the opioid overdose population (n = 235,178) were male (70%). Most patients were 30 - 49 years old (48.3%). Among patients, white non-Hispanics had the highest opioid overdose. Nearly all counties showed increasing rates of overdoses over six years. The high overdose clusters were identified in Niagara, Orleans, Genesee, Madison, Chenango, Delaware, and Sullivan counties (P < 0.05). The highest overdose rates were identified in the Central and Eastern New York regions.

CONCLUSIONS

The areas of highest overdose deaths among opioid use disorders were not necessarily the areas with the highest usage rates. This tells us that public health services may be lacking in these communities and this represents an opportunity for the New York Department of Public Health to improve our education and public health response in these communities. Opioid use and overdose rates do not always correlate well. This shows that special attention to counties with high overdose/user rates is warranted. The findings could inform health policy decisions at the county and state levels based on the geographic and demographic patterns to prevent and control opioid crises.
Correction: Real-Time Forecasting of the COVID-19 Outbreak in Chinese Provinces: Machine Learning Approach Using Novel Digital Data and Estimates From Mechanistic Models (Preprint)
Authors: Liu Dianbo , Clemente Leonardo , Poirier Canelle , Ding Xiyu , Chinazzi Matteo , Davis Jessica , Vespignani Alessandro , Santillana Mauricio
Published: September 2020

UNSTRUCTURED

The inherent difficulty of identifying and monitoring emerging outbreaks caused by novel pathogens can lead to their rapid spread; and if left unchecked, they may become major public health threats to the planet. The ongoing coronavirus disease (COVID-19) outbreak, which has infected over 2,300,000 individuals and caused over 150,000 deaths, is an example of one of these catastrophic events. We present a timely and novel methodology that combines disease estimates from mechanistic models and digital traces, via interpretable machine learning methodologies, to reliably forecast COVID-19 activity in Chinese provinces in real time. Our method uses the following as inputs: (a) official health reports, (b) COVID-19–related internet search activity, (c) news media activity, and (d) daily forecasts of COVID-19 activity from a metapopulation mechanistic model. Our machine learning methodology uses a clustering technique that enables the exploitation of geospatial synchronicities of COVID-19 activity across Chinese provinces and a data augmentation technique to deal with the small number of historical disease observations characteristic of emerging outbreaks. Our model is able to produce stable and accurate forecasts 2 days ahead of the current time and outperforms a collection of baseline models in 27 out of 32 Chinese provinces. Our methodology could be easily extended to other geographies currently affected by COVID-19 to aid decision makers with monitoring and possibly prevention.
Perhitungan Burn Up pada Reaktor HCLWR Model Geometri Kotak Tiga Dimensi dengan Bahan Bakar Thorium Menggunakan Kode COREBN
Authors: Handayani Hasni , Yulianti Yanti , Manurung Posman
Published: September 2020

Penelitian tentang perhitungan burn up pada reaktor HCLWR model geometri kotak tiga dimensi dengan bahan bakar thorium menggunakan kode Corebn telah dilakukan. Perhitungan dilakukan dengan simulasi komputasi menggunakan kode COREBN pada program System Reactor Atomic Code (SRAC). Parameter yang dianalisis pada penelitian ini meliputi pengayaan bahan bakar, periode, total power, dan konfigurasi. Hasil perhitungan memperoleh semakin besar persentase pengayaan pada U233, maka nilai keff akan semakin meningkat. Persentase yang optimal pada pengayaan bahan bakar U1 1% dan U3 4%. Semakin lama periode burnup (385 – 405 hari) dan besar total power (244-247 MWt), maka nilai keff  akan menurun dan nilai CR meningkat. Perubahan konfigrasi memperoleh rapat daya maksimum 336,0367 Watt/cm3dan nilai rapat daya yang konstan pada kolom x baris y, dan z. Desain reaktor yang dapat menghasilkan nilai rasio konversi 1 dengan keff dapat membuat reaktor menyala hingga akhir yaitu ketika pengayaan bahan bakar U1 1% dan U3 3%, periode 150 hari dan fraksi volume 45,0% bahan bakar, 11,3% selongsong, 43,7% moderator.
Síndrome de OHVIRA, a propósito de un caso
Authors: Paz-Montañez John Jamer , Gaitán-Guzmán Luisa Fernanda , Acosta-Aragón María Amparo
Published: September 2020

Introducción: El síndrome de obstrucción hemivaginal y anomalía renal ipsilateral (OHVIRA, por sus siglas en inglés) o también llamado síndrome de Herlyn-Werner-Wunderlich es una rara malformación mulleriana que consiste en la presencia de útero didelfo, obstrucción hemivaginal y anomalía renal ipsilateral. La incidencia de malformaciones mullerianas son del 2 al 3%, y la menos común es el síndrome de OHVIRA. Objetivo: Descripción de un caso excepcional de alteraciones mullerianas poco conocido. Presentación del caso: Adolescente de 14 años con historia de dolor pélvico, dismenorrea e infecciones urinarias a repetición. Se estudió con gammagrafía renal que reveló agenesia renal derecha y resonancia magnética pélvica que mostró útero didelfo con hematocolpos derechos. Se confirmaron los hallazgos por laparoscopia diagnóstica. Conclusiones: Este síndrome es poco conocido. Debe sospecharse en casos de agenesia renal, dolor pélvico crónico y alteraciones menstruales en pacientes postpuberes. El abordaje es multidisciplinario.
Other-Regarding Virtues and Their Place in Virtue Argumentation Theory
Authors: Oliveira de Sousa Felipe
Published: September 2020

In this paper, I argue that, despite the progress made in recent years, virtue argumentation theory still lacks a more systematic acknowledgment of other-regarding virtues. A fuller recognition of such virtues not only enriches the field of research of virtue argumentation theory in significant ways, but also allows for a richer and more intuitive view of the virtuous arguer. A fully virtuous arguer, it is argued, should care to develop both self-regarding and other-regarding virtues. He should be concerned both with his own development as an arguer and with helping other arguers in that regard.
Review of Narration as Argument, edited by Paula Olmos
Authors: Dosser Max
Published: September 2020

This article reviews Paula Olmos’s Narration as Argument collection (Springer 2017).
Representação política e gastos orçamentários: um estudo sobre as ações e a política orçamentária da câmara de vereadores de Erechim (RS)
Authors: Toledo Elziário Noé Boeira , Menegazzo Giovanni Dutra , Da Rocha Humberto José
Published: September 2020

O estudo tem por objetivo analisar a atuação e a disponibilidade de recursos financeiros do Poder Legislativo do município de Erechim (RS). A análise da atuação foi realizada conforme as funções estabelecidas pela Controladoria Geral da União (CGU), enquanto a disponibilidade de recursos financeiros foi examinada de forma comparativa com municípios de população e localização geográfica similares, resultando em uma amostra composta por oito municípios, além de Erechim. Os dados foram observados de modo descritivo a partir da sua coleta nos portais de transparência de cada município. Os resultados da pesquisa apontam que 83% das ações da Câmara Legislativa de Erechim não condizem com as funções estabelecidas pela CGU. Observou-se também que o orçamento, os gastos e o número de vagas no Legislativo de Erechim estão acima da média dos demais municípios analisados, fatores que sugerem uma readequação das ações, do número de vagas e da política orçamentária do Legislativo de Erechim.
Eleições e sistema eleitoral africano: desafios e perspectivas para Moçambique
Authors: Thay Antonio Hama
Published: September 2020

O presente artigo faz uma análise sobre a questão das eleições e o sistema eleitoral africano. O estudo sistematiza desafios e perspectivas para Moçambique, um país africano cujo processo eleitoral tem degenerado em tensões, conflitos e crises pós-eleitorais. Baseado numa pesquisa qualitativa, apoiada pelo método histórico e analítico, pesquisa documental, revisão sistemática de literatura e observação participante, o estudo constatou que o sistema eleitoral africano está em processo de construção, acreditando que num futuro próximo ou longínquo irá adquirir sua forma autóctone, segura e funcional capaz de evitar e reduzir conflitos eleitorais e pós-eleitorais.
Is Corporate Social Responsibility Related to Corporate Tax Avoidance? Evidence from a Natural Experiment
Authors: Mayberry Michael A. , Watson Luke
Published: September 2020

We employ states' enactment of constituency statutes as plausibly exogenous shocks to the marginal cost of corporate social responsibility (CSR) and examine the relation between CSR and corporate tax avoidance. We find almost no evidence of an association between the enactment of constituency statutes and tax avoidance. We use confidence intervals and other analysis to rule out low power as an explanation. Using an instrumental variables design, we find evidence that third-party CSR scores increase following constituency statutes, yet without a detectable impact on tax avoidance. The lack of results across multiple proxies and specifications suggests firms decouple CSR from tax policy. Our study introduces a strong identification strategy common in management research to the accounting literature, producing a novel no-result finding on a popular research question.
Intention to Champion Continuous Monitoring: A Study of Intrapreneurial Innovation in Organizations
Authors: Curtis Mary B. , Chui Lawrence , Pavur Robert J.
Published: September 2020

Innovations in organizations often arise through the efforts of intrapreneurs—entrepreneurial-oriented employees who typically work outside of their day-to-day job responsibilities. Currently, little research has addressed this important source of innovation. Using Innovation Value Chain theory, we theorize that individual, organizational, and innovation-specific factors influence intrapreneurial innovation, operationalized as managerial accountants' intentions to champion the adoption of an IT innovation within their organizations. Additionally, we consider how information system complexity may influence these factors. We test our model using a structural equation model (SEM) with 320 management accountants. Perceptions of organizational orientation toward innovation and of the technology are significant determinants of individuals' intention to champion the adoption of continuous monitoring. Individual inclination to innovate is not significant in the presence of the other two factors. We also find that system complexity lowers perceptions of the technology's benefits, thus inhibiting intention to champion.
Childhood Body Mass Index and Fasting Glucose and Insulin Predict Adult Type-2 Diabetes: The International Childhood Cardiovascular Cohort (i3C) Consortium
Authors: Hu Tian , Jr. David R. Jacobs , Sinaiko Alan R. , Bazzano Lydia A. , Burns Trudy L. , Daniels Stephen R. , Dwyer Terry , Hutri-Kähönen Nina , Juonala Markus , Murdy Kari A. , Prineas Ronald J. , Raitakari Olli T. , Urbina Elaine M. , Venn Alison , Woo Jessica G. , Steinberger Julia
Published: September 2020

Objective: To examine childhood body mass index
(BMI), fasting glucose and insulin in relation to incident adult type-2
diabetes mellitus (T2DM).

Research Design and Methods: We used data from The
International Childhood Cardiovascular Cohort Consortium. Data included
childhood measurements (age 3-19) obtained during the 1970s-90s, a health
questionnaire including self-report of adult T2DM (occurrence age, medication
use) obtained at mean age 40 years, and a medical diagnosis registry (Finland).

Results: The sample included 6,738
participants. Of these, 436 (6.5%)
reported onset of T2DM between ages 20-59 (mean 40.8) years, and 86% of them reported
use of a confirmed anti-diabetic medication. BMI and glucose (age- and
sex-standardized) were associated with incident T2DM after adjustment for cohort,
country, sex, race, age and calendar year of measurement. Increasing levels of
childhood BMI and glucose were related to incrementally increased risk of T2DM
beginning at age 30, beginning at cut points below the 95th
percentile for BMI and below 100 mg/dL for glucose. Insulin was positively
associated with adult T2DM after adjustment for BMI and glucose and added to
T2DM discrimination.

Conclusions:
Childhood BMI and glucose
are predictors of adult T2DM at levels previously considered to be within the normal
range. These easy to apply measurements are appealing from a clinical
perspective. Fasting insulin has the potential to be an additional predictor.
Exploring the Innate Human Potential for Positive Adaptation in the Face of Impending Mortality: Is there a Response Shift in Subjective Quality of Life over Time in a Group of Patients with Lung Cancer Receiving Palliative Treatment?
Authors: Mannion Dr. Eileen , Gilmartin Professor JJ , McInerney Dr. Veronica , Molony Ms Kate , Basquille Ms Emily , Waldron Prof Dympna
Published: September 2020

Traditionally changes in quality of life (QoL) are assessed using self report questionnaires. They rely on the assumption that the patient’s point of reference does not change over time. However in reality patients with chronic and life threatening illness appear to undergo an adaptation to their disease or “Response Shift” (RS). In this study of a population of patients with advanced lung cancer receiving palliative chemotherapy we examine for a RS in subjective QoL. Methods: 33 patients completed the Schedule for the Evaluation of Individual Quality of Life (SEIQoL), SEIQOL–DW and the EORTC-QLQ C-30 at diagnosis. At 1, 3 and 6 months patients completed SEIQoL/ SEIQOL–DW and retrospectively re-assessed their baseline QoL (the “then” test) using SEIQoL-DW. Results: The initial mean SEIQoL-DW score was 67.48 changing to 66.71 at one month. Retrospectively, patients reassessed their initial mean SEIQoL-DW score as 59.61, suggesting a RS of 7.87 (p ≤0.0001) and an actual improvement in QoL of 7.1 points. At three months the mean SEIQoL-DW score was 65.13; retrospectively patients rated their QoL at one month much lower, mean SEIQoL-DW then – test’ score was 59.92, suggesting a RS of 6.79 (p = 0.0013). At six months patients’ mean SEIQoL-DW score was 61.86. Again, when retrospectively rating their QoL at three months they rated it lower, mean SEIQoL-DW score of 58.84, indicating a ‘positive’ RS of 6.28 (p = 0.0007). Conclusion: Traditional pre/post SEIQOL–DW scores show little change in subjective QOL however by incorporating the ‘then-test’ we can see that patients have undergone a RS and a significant positive change in subjective QOL. By explicitly measuring RS it may be possible to assess changes in QoL with greater validity and sensitivity.
Layanan Konsultasi Dalam Membantu Menangani Kasus Anak Korban Kekerasan Dalam Rumah Tangga di Pusat Pelayanan Terpadu Pemberdayaan Perempuan Dan Anak (P2tp2a) Provinsi Riau
Authors: Zulamri Zulamri
Published: September 2020

Berbagai kasus kekerasan yang sering terjadi pada anak di dalam rumah membawa efek tersendiri bagi perkembangan kejiwaan anak. Kekerasan psikis, kekerasan fisik, penelantaran, sampai pada kekerasan seksual. Kasus kekerasan anak banyak terjadi disebabkan oleh faktor ekonomi, konflik antara orang tua, kesibukan orang tua bekerja di luar rumah sehingga berujung pada penelantaran dan sebagainya, hal semacam inilah yang dapat membuat anak mengalami stres, trauma, putus asa, menyendiri, terjerumus kepada kenakalan-kenakalan remaja seperti Narkoba, seks bebas bahkan ingin bunuh diri pasca tindak kekerasan.  Akibat dari itu anak yang menjadi korban kekerasan akan mengalami gejolak psikis seperti stress, mengurung diri, rasa takut dan trauma dan bahkan sampai pada tahap ingin bunuh diri. dalam persoalan kekerasan ini mereka sangat membutuhkan layanan konseling untuk mengatasi dampak pasca kekerasan tersebut sampai pada proses penyembuhan. Salah satu layanan konseling yang dapat dilakukan yaitu layanan konsultasi. sejauh ini kasus kekerasan pada anak di Propinsi Riau sudah ada penanganan intensif yang dilakukan oleh P2TP2A Propinsi Riau.Kata Kunci : Layanan Konsultasi, Anak Korban KDRT
Kondisi Psikologis Personil Tni-Ad Menghadapi Pensiun
Authors: Rubani Mardhiah
Published: September 2020

Pembahasan ini bertolak dari pemikiran bahwa perlunya persiapan menghadapi pensiun. Melihat fenomena yang terjadi, ternyata ada sebagian pensiunan yang mengalami ketidaktenangan jiwa dalam menjalani masa pensiun. Ada mereka yang terkejut atas perubahan yang dialami setelah pensiun, yakni: biasanya mereka seorang pekerja yang sibuk, tekun dan optimis, kini hanya berdiam diri saja di rumah; biasanya mereka bersosialisasi dengan rekan-rekan kerjanya, kini hubungan tersebut terputus karena mereka tidak bekerja lagi sedangkan rekannya masih bekerja. Melihat gejala-gejala diatas kemungkinan disebabkan oleh kondisi jiwa yang tidak siap menghadapi pensiun. Ini pertanda perlunya mempersiapkan diri dalam menyongsong masa pensiun. Kesiapan seseorang menghadapi pensiun diawali dengan kesiapan mereka menyongsong pensiun. Begitu pula kiranya yang terjadi pada diri personil TNI-AD Makorem 031/Wirabima. Untuk menjawab permasalahan tersebut, penulis mengumpulkan data yang diperlukan melalui wawancara mendalam pada informan Kata kunci:Personil TNI-Ad, Kondisi jiwa, Pesiun
It’s Complicated: The Relationship Between Participation in Academic Coaching and Program Completion in Online Graduate Students
Authors: Lehan Tara , Shriner Bethanne , Shriner Michael
Published: September 2020

Among graduate students at one completely online university, it previously was found that participation in synchronous one-on-one academic coaching even once increased the odds of persistence 6 to 9 months later 2.66 times. To examine the longer-term impact of this service, this study was designed to investigate the relationship with program completion by comparing the same random sample of students who participated in academic coaching to the same matched sample of students in the same course with the same faculty member at the same time. In the academic coaching sample, the more times these students worked with an academic coach, the greater their odds were of completing their program. However, when the students from the matched sample (all of whom had 0 academic coaching sessions by definition) were added to the analysis, this relationship was no longer statistically significant. It was determined that the previously observed relationship between participation in synchronous one-on-one academic coaching and persistence in online graduate students might not endure through program completion, although the relationship between several demographic and academic variables and program completion did remain statistically significant. In light of these findings, if the goal is to increase their odds of completion, it seems that students who are already engaging with an academic coach (due to either self-selection or faculty encouragement/requirement) might be encouraged to continue to do so. Moreover, a “booster” coaching session might be helpful. However, there is insufficient evidence to support the practice of requiring participation in academic coaching among students who do not do so on their own.