bluuebunny/crossref_metadata_2025 huggingface dataset:
Atividade inferencial na compreensão leitora de gêneros textuais da matemática escolar
Authors: Barbosa Rosane Mendes , Ripardo Ronaldo Barros
Published: August 2023

Este artigo tem o objetivo de analisar a produção de inferências de alunos dos anos finais do Ensino Fundamental na leitura de diferentes gêneros textuais da matemática escolar. Tem como fundamento teórico as discussões de Marcuschi (2008) acerca da produção de inferências no processo de leitura. A abordagem é quantitativa, de larga escala, e se trata de um estudo de caso exploratório. A produção de dados foi realizada com 387 alunos de 14 escolas do campo e da cidade do município de Canaã dos Carajás, Estado do Pará, a partir da aplicação de uma prova de leitura constituída por cinco Testes Cloze utilizando diferentes gêneros textuais da matemática escolar. Os resultados apontam maior ocorrência de acertos no preenchimento das lacunas que mobilizam as inferências de base textual. Concluímos que esse processo de inferenciação, baseado em informações intratextuais, não parece ser influenciado pelo gênero do texto matemático.
La Política Pública para el Apoyo y Fortalecimiento a las Familias en Antioquia: una construcción colectiva incluyente, participativa y colaborativa
Authors: Ramírez Hernández Leidy Tatiana , Lopera Bonilla Olga Cecilia , Rodríguez Bustamante Alexánder
Published: August 2023

En las conversaciones surgidas en la Mesa Departamental de Familias de Antioquia, se consideró la pertinencia de elaborar un artículo metodológico que diera debida cuenta del trabajo incluyente, participativo y colaborativo de quienes a lo largo de los años 2013 a 2019 se involucraron activamente en el proceso de formulación de la Política Pública para el Apoyo y Fortalecimiento a las Familias en Antioquia, en cumplimiento a lo dispuesto por la Ley 1361 de 2009 (modificada por la Ley 1857 de 2017), todo lo cual derivó en la aprobación de la Ordenanza 47 de Diciembre 30 de 2019, por voto unánime de los miembros de la Asamblea Departamental. En su actual etapa de implementación por parte de la Gobernación de Antioquia, una de las labores de la Mesa es continuar acompañando la gestión de la Política Pública en favor de las familias que habitan el territorio del departamento.
Estudo da incorporação do resíduo escória de chumbo para fabricação de blocos para pavimento intertravado
Authors: Rafaeli Letícia Akari Inoue , Carelli Jhulis Marina , Foiato Maiara
Published: August 2023

O desenvolvimento de métodos para reaproveitamento de resíduos é alvo de estudo, pois estes melhoram a qualidade ambiental, uma vez que transformam resíduos em subproduto para novos processos fabris. O resíduo escória de chumbo, proveniente da reciclagem de baterias usadas e da extração e refino do chumbo secundário, atualmente tem sido armazenado e descartado em aterros devido à falta de tecnologias alternativas para sua reciclagem. Tecnologias limpas a custo competitivo têm feito que empresas revejam suas políticas priorizando essas soluções. Neste estudo foi realizada a confecção de peças de concreto para pavimentação que constituem o pavimento intertravado, onde foi utilizado cimento Portland V-ARI, buscando o melhor traço de concreto com substituição do agregado miúdo pelo resíduo escória de chumbo em três teores, 10%, 20% e 30%. Realizou-se traços com inserção de aditivo e sem aditivo, foram realizados ensaios no estado fresco e no estado endurecido para avaliação de todos os traços. No estado fresco foram realizados o ensaio de abatimento de tronco de cone para obter os resultados do slump de cada traço e ensaio de massa específica para posterior avaliação do custo-benefício dos traços. Já no estado endurecido foram realizados ensaio de resistência à compressão, absorção de água, avaliação dimensional e inspeção visual. Os resultados permitiram avaliar que a mistura do traço com aditivo e 10% do resíduo escória de chumbo atingiu resistência característica à compressão de 28,1 MPa. Segundo a normativa que regulamenta as peças de concreto para pavimentação, as peças destinadas ao tráfego de pedestres, veículos leves e veículos comerciais de linha devem atender a resistência característica à compressão ≥35 MPa, sendo que os lotes com idade inferior a 28 dias devem apresentar no mínimo 80% do Fpk, sendo então de 28 MPa. Quanto aos parâmetros de absorção de água, avaliação dimensional e inspeção visual o traço E10-CA apresentou resultados positivos, indicando o potencial uso da escória na fabricação de blocos de concreto para pavimento intertravado. Ainda, quanto a avaliação do custo-benefício da incorporação do resíduo escória de chumbo, apresentou economia em relação ao traço referência. Conclui-se que as empresas de reciclagem de chumbo secundário devem continuar os estudos em relação ao uso do resíduo escória de chumbo na fabricação de blocos de concreto para pavimentação, dando ênfase a estudos de lixiviação das peças, visto que a o resíduo contêm concentrações de chumbo, para então poderem contar com uma tecnologia viável para reciclagem do resíduo com menor custo e segurança ambiental.
Estudo de melhoramento de traço para base de pavimento flexível em brita graduada simples
Authors: Contini Miguel , Luvizão Gislaine
Published: August 2023

O modal mais utilizado no Brasil para tráfego e transportes é o rodoviário, e com isso se faz necessário melhorar cada vez mais as condições dos pavimentos, bem como o controle da execução do pavimento como um todo, partido das camadas inferiores. Com base nisso, este estudo buscou avaliar o processo de dosagem e execução de base estabilizada granulometricamente por empresa localizada no município de Ibicaré/SC, visando solucionar possíveis problemas relacionados ao resultado final do processo. Inicialmente acompanhou-se o processo de execução do traço dosado pela empresa, sendo possível identificar incoerências como variação da britagem e perda de materiais finos durante o processo de homogeneização, transporte e espalhamento da mistura. Com isso, se tornou essencial a elaboração de um traço experimental buscando minimizar as perdas, atendendo as exigências das normas técnicas do Departamento Nacional de Infraestrutura de Transporte. Os resultados da nova mistura foram relacionados com a mistura da empresa e com os parâmetros normativos. É importante evidenciar que o ensaio da viga de Benkelman foi de extrema importância, visto que ele é responsável por apresentar e identificar a deflexão máxima da camada de estudo juntamente com seu raio de curvatura. A correção de filler na mistura se deu com a adição de 5% de filler durante o processo de homogeneização, valor da perda encontrado após ensaios de granulometria de várias misturas. Contudo, a variação da britagem não foi corrigida, mas, partindo dos resultados das granulometrias periódicas executadas pela empresa, foi possível obter um valor médio de variação e um desvio padrão, tendo assim uma granulometria mais próxima do real. Para aferir o desempenho em campo foi executada pista experimental em um trecho de 20 metros em obra de pavimentação no município de Capinzal/SC. Os resultados da nova mistura foram positivos relacionados com a mistura da empresa e com os parâmetros normativos. O ensaio da viga de Benkelman se mostrou positivo, atendendo as prescrições adotadas apresentando valor calculado de 61 x10-2 mm de deflexão máxima e 188 metros de raio de curvatura. Por fim, conclui-se que a adição de filler a fim de corrigir a perda do mesmo na homogeneização apesar de melhorar o traço, não se torna a solução mais econômica para a empresa pois isso pode encarecer cerca de R$ 6,40 reais na tonelada da mistura. Porém em contrapartida o problema na perda de filler pode ser solucionado alterando o método de homogeneização de forma mecânica por pá carregadeira para centrais de dosagem, esta que a empresa já possui, mas será necessário um estudo para adequação.
Avaliação das manifestações patológicas da ponte pênsil Padre Mathias Michelizza localizada entre os municípios de Capinzal e Ouro, em Santa Catarina
Authors: Formaio Ana Lara , Ferreira Chaiana Bertusso , Nora Renata Fernanda , Flamea Sabrina Grabrieli , Silva Vitória Regina da , Nienov Fabiano Alexandre
Published: August 2023

As pontes são obras destinadas a vencer obstáculos de superfície líquida que impeçam a continuidade de uma via e são tecnicamente conhecidas como obras de arte especiais (OAE). Além disso, são elementos importantes de muitas cidades por beneficiarem a mobilidade e atraírem turistas pelo seu significado histórico e cultural. Contudo, a exposição ao meio em que estão inseridas torna as pontes suscetíveis a diversas manifestações patológicas que podem, ao longo do tempo, comprometer sua estrutura. Neste viés, o presente estudo visa avaliar as origens e características das manifestações patológicas presentes na ponte pênsil Padre Mathias Michelizza, localizada entre os municípios de Capinzal e Ouro, em Santa Catarina. Para tanto, realizou-se inspeção rotineira conforme NBR 9452 (2019) cuja metodologia consiste em identificar anomalias na estrutura por meio de inspeções visuais e registros fotográficos e, após isso, avaliar as condições da ponte, associando notas aos parâmetros estrutural, funcional e de durabilidade. Ademais, foram realizadas medições dos componentes da ponte a fim de verificar o atendimento às normativas vigentes e também foi realizado um levantamento histórico acerca das alterações e das manutenções ocorridas na estrutura ao longo dos anos. Verificou-se que a ponte, construída em 1934 com o objetivo de interligar os povoados de Capinzal e Ouro, passou por diversas modificações estruturais devido as mais diversas ações climáticas na região, sendo atualmente constituída de madeira, aço e concreto e utilizada apenas para passagem de pedestres. Constatou-se também que a OAE em questão apresenta manifestações patológicas tanto em sua estrutura de madeira como de concreto e metálica, sendo que as principais anomalias encontradas são fissuras, trincas, rachaduras, armaduras expostas, corrosão dos elementos metálicos, biodeterioração e ruptura dos cabos de aço de sustentação da estrutura. Diante disto, torna-se indispensável ações de recuperação das estruturas danificadas, como substituição dos elementos corroídos e rompidos. Além disso, ressalta-se a importância da realização de manutenções preventivas no que tange à vida útil da estrutura e à segurança dos usuários.
Estudo da viabilidade de utilização do método de construção modular em um projeto FNDE Proinfância tipo 2
Authors: Fernanda Schiehl Graziela , Lockstein Scheila
Published: August 2023

A construção modular é um método que utiliza módulos com medidas padronizadas a fim de facilitar a execução da obra, sendo conhecido pela rapidez e sustentabilidade na construção. Para identificar sua viabilidade de utilização foram realizadas pesquisas bibliográficas e a adaptação do projeto do Fundo Nacional de Desenvolvimento da Educação (FNDE) Proinfância tipo 2, fornecido pelo Ministério da Educação (MEC), através do Software AutoCAD, buscando manter o layout similar ao projeto original e respeitar as normas e legislações vigentes. O comparativo foi efetuado através da orçamentação do método convencional com o projeto original, por meio da planilha fornecida pelo MEC. Já a cotação pelo método modular foi realizada por intermédio de empresas da área, onde a Polibox elaborou um orçamento preliminar com base no projeto adaptado e a empresa Home Lux & Work, que disponibiliza valores mínimos dos módulos em seu site, possibilitou uma estimativa do custo para a execução da edificação. Confrontando os três orçamentos foi possível identificar que o método convencional apresentou valores 11,31% e 25,56% menores que o método modular da empresa Polibox e Home Lux & Work, respectivamente. Em contrapartida, foi possível constatar através da comparação dos cronogramas fornecidos pelo MEC e pela Polibox que a execução pelo método modular é 37,5% mais rápida em relação ao convencional, tornando-o viável, pois a edificação finalizada em um tempo inferior significa que as atividades também poderão ser iniciadas antes do esperado, atendendo as necessidades.
Estudo de solo-cimento com a incorporação de resíduo proveniente do beneficiamento secundário de rochas ornamentais
Authors: Silva Eliziane , Nienov Fabiano Alexandre
Published: August 2023

O presente estudo visa oferecer uma alternativa de reaproveitamento do resíduo produzido em marmorarias, avaliando o comportamento de misturas de solo-cimento com substituição parcial da areia pelo rejeito. Foram analisados parâmetros como a resistência à compressão simples, absorção de água e porosidade dos corpos de prova. Para tanto, elaborou-se traços com percentuais de substituição de 0%, 5%, 10%, 15% e 20%, enquanto o cimento foi utilizado como adição em 10%. Observou-se que o acréscimo do resíduo elevou a massa específica aparente seca e a resistência à compressão e reduziu a absorção de água. A melhor resistência obtida foi de 15,20 MPa com a mistura A80-R20-C10 (areia- resíduo-cimento) aos 28 dias de cura, equivalente a um aumento de 122,55% da resistência alcançada no traço sem resíduo. De igual modo, o menor valor da absorção foi de 0,75%, verificado na mistura A80-R20-C20 (areia- resíduo-cimento), aos 7 dias de cura. Diante disto, o resíduo se mostra com potencial para a aplicação em solo-cimento para utilização em bases e sub-bases de pavimentos, em tijolos ecológicos, paredes monolíticas e em contenções, aspirando à preservação ambiental, à melhora das propriedades físicas e mecânicas e à economia.
Avaliação do desempenho térmico de coberturas com a substituição de manta térmica por embalagens Tetra Pak-®
Authors: Zanella Kelen , Foiato Maiara , Carelli Jhulis Marina
Published: August 2023

Conforto térmico é um termo utilizado para descrever a satisfação de um ser humano em um determinado espaço com relação à temperatura do mesmo. Uma das maneiras de se garantir esse conforto é utilizando mantas térmicas em coberturas associadas à um tipo de telha que auxilie neste processo. O objetivo do estudo foi avaliar embalagens Tetra Pak-® substituindo estas mantas que são encontradas em lojas de construção. Para isto, executou-se placas com embalagens dispostas em posições diferentes, com o alumínio disposto para cima, para baixo e de forma intercalada, com união diversificada das mesmas, tipo coladas, grampeadas e costuradas, uma e duas camadas e ainda com telhas distintas, sendo elas, telhas cerâmicas, fibrocimento e metálicas. Além desses, para fins de comparação, fez-se o teste com a manta dupla face disponível no mercado local. Os ensaios de medição de temperatura foram realizados em protótipos com o uso do termo higrômetro digital, medindo-se as temperaturas internas e externas durante 3 dias de cada simulação e em 5 horários distintos em cada dia. Chegou-se a resultados positivos quando comparadas as placas confeccionadas de embalagens Tetra Pak-® com a manta aluminizada. Verificou-se pela avaliação dos resultados que a combinação para atingir um melhor conforto térmico foi utilizando as embalagens coladas entre si para formar a placa e com a face aluminizada voltada para cima (sentido da telha). E para essa combinação a diferença de temperatura externa e interna foi de aproximadamente 7,7°C, sendo que, a manta dupla face comercializada apresentou redução de 6,9ºC. Observou-se que independentemente de como as embalagens estão dispostas e com qual telha estão sendo utilizadas, o seu uso pode ocasionar melhor conforto térmico no verão, além de ser uma opção sustentável visto a reciclagem das embalagens.
Regulacja funkcji kanałów jonowych Na+ przez receptory opioidowe
Authors: Witkowski Grzegorz , Szulczyk Paweł
Published: August 2023

Receptory opioidowe typu ц należą do grupy receptorów opioidowych,
które m odyfikują funkcję licznych efektorów błonowych (cyklaza adenylowa,
kanały jonow e K+, Ca++ i Na+) i cytoplazmatycznych (aktywacja fosfolipazy A2,
kinazy białkowej typu C, kinazy МАРК, hamowanie kinazy białkowej typu A).
Fosforylacja potencjałozależnych kanałów jonowych Na+ przez kinazę białkową
typu A i С prowadzi do zmiany kinetyki prądu jonowych N a+. Celem pracy było
zbadanie mechanizmu transdukcji sygnału od receptora opioidowego typu ц do
potencjałozależnych kanałów jonowych. Receptory opioidowe aktywowano
przez podanie DAM GO - syntetycznego, specyficznego agonisty receptora ц.
Podanie DAMGO wywoływało spadek amplitudy oraz zmianę kinetyki prądu
jonowego Na+ w neuronach niepiramidowych. Efekt był hamowany po podaniu
inhibitorów kinaz białkowych A i C. Z kolei podanie aktywatora kinazy A i С
zmieniało kinetykę i amplitudę prądu jonowego N a+ w sposób podobny do
DAMGO. W neuronach piramidowych kory przedczołowej nie wykazano
wpływu aktywacji receptora opioidowego typu ц na prąd jonow y N a+. Wnioski:
W neuronach niepiramidowych kory przedczołowej aktywacja receptorów
opioidowych typu ц moduluje funkcje potencjałozależnych kanałów jonowych
Na+ w mechanizmie zależnym od kinazy białkowej A i C.
Wpływ fłurazepamu i zewnątrzkomórkowego pH na amplitudę i kinetykę GABA ergicznych prądów synaptycznych w hodowanych neuronach z hipokampa szczura
Authors: Brzeźnicki Piotr , Pindel Ewa , Wójtowicz Tomasz , Piast Michał , Mozrzymas Jerzy W.
Published: August 2023

Stężenie jonów wodorowych (pH) i benzodiazepiny (BDZ) są czynnikami
modulującymi receptory GABAa. W szczególności, wartość pH środowiska
zewnątrzkomórkowego może zmieniać się w zależności od stanu
fizjologicznego lub patologicznego. W niniejszej pracy przedstawiono wyniki
badań wpływu flurazepamu (benzodiazepiny) przy różnych wartościach
zewnątrzkomórkowego pH (z zakresu 5.5 - 7.2) na amplitudę miniaturowych
GABA-ergicznych inhibujących prądów synaptycznych (mIPSCs). Stwierdzono,
że obecność flurazepamu prowadzi do zwiększenia amplitudy mIPSCs, ale efekt
ten zależy od pH i je st największy przy silnie kwaśnych wartościach. Wpływ
flurazepamu na amplidudę mIPSC osiąga nasycenie przy stężeniu ok. I цМ dla
wszystkich badanych wartości pH. Wyniki te wskazują na to, że modulacja
Prądów GABAergicznych przez benzodiazepiny jest zależna od odczynu
środowiska.
Zastosowanie woltametrii w badaniach neurofizjologicznych
Authors: Wieczorek Marek , Palamarchouk Vitaly S.
Published: August 2023

Stosowana w badaniach neurofizjologicznych woltametria wywodzi się
bezpośrednio z analitycznych metod elektrochemicznych i jest zbliżona do
polarografii. Metoda ta, w odróżnieniu od chromatografii czy mikrodializy nie
wymaga pobierania i przygotowywania próbek do późniejszych badań. Cała
analiza odbywa się w miejscu, gdzie dany proces zachodzi (w określonej
strukturze ośrodkowego układu nerwowego, gdzie ma miejsce uwalnianie
neurotransmiterów), a co najważniejsze, pomiar odbywa się w czasie
rzeczywistym [20].
Współcześnie stosowane urządzenia pozwalają dokonywać analizy pracy
systemów neurotransmisyjnych mózgu w sposób telemetryczny — nie
ograniczając tym samym możliwości poruszania się zwierzęcia w kamerze
doświadczalnej. Taką procedurę można stosować do, połączonych
z behawiorem, obserwacji zmian neurochemicznych i bioelektrycznych mózgu.
Interakcje między neurotoksynami na poziomie układu nerwowego owadów
Authors: Stankiewicz Maria , Ciołek Justyna , Grolleau Françoise , Kielbasiewicz Ewa , Kądziela Wojciech , Pelhate Marcel , Corbel Vincent , Lapied Bruno
Published: August 2023

Interakcje między pyretroidami i karbaminianem oraz toksyną ATX II
z jadu anemona morskiego Anemonia sulcata były badane z użyciem metody
pojedynczej i podwójnej przegrody olejowej. Obserwowano czynność
bioelektryczną synaps w ostatnim zwoju odwłokowym oraz izolowanego aksonu
olbrzymiego z układu nerwowego karaczana Periplaneta americana. Wykazano:
(1) synergizm między permetryną (pyretroidem I typu) i propoksurem
(karbaminianem), (2) przyspieszenie działania deltametryny (pyretroidem II
typu) w obecności toksyny ATX II oraz brak wpływu toksyny na efektywność
permetryny.
Elektrofizjologiczne badania neuronalnych mechanizmów plastyczności kory baryłkowej myszy wywołanych uczeniem się
Authors: Tokarski Krzysztof , Urban-Ciećko Joanna , Hess Grzegorz
Published: August 2023

Awersyjne warunkowanie klasyczne, polegające na skojarzeniu stymulacji
dotykowej jednego z rzędów wibrys, jako bodźca warunkowego (CS), z szokiem
elektrycznym w ogon, jako bodźcem bezwarunkowym (UCS), wywołuje
powiększenie rozmiarów funkcjonalnych reprezentacji stym ulowanych wibrys
w korze somatosensorycznej myszy, co wykazano przy zastosowaniu pomiarów
aktywności metabolicznej tkanki nerwowej [13]. Efekt ten ma charakter uczenia
asocjacyjnego. Dane literaturowe wskazują, źe po zakończeniu treningu,
w obszarach stanowiących reprezentacje stymulowanych wibrys dochodzi do
wzrostu poziomu markerów GABAergicznego przekaźnictwa synaptycznego.
Jak dotąd, brak jednak danych na temat modyfikacji funkcji neuronów korowych
i ich połączeń, które mogą być efektem zmian plastycznych. Celem wykonanych
badań było określenie, które elementy sieci neuronalnej kory
somatosensorycznej ulegają modyfikacjom w efekcie awersyjnego
warunkowania klasycznego. Badania prowadzone były metodami rejestracji
elektrofizjologicznej ex vivo z pojedynczych neuronów whole-cell patch-clamp
w skrawkach kory somatosensorycznej myszy, poddanych wcześniej
warunkowaniu awersyjnemu. W pierwszym etapie badań przeprowadzono
charakterystykę elektrofizjologiczną glutaminianergicznych neuronów
pobudzających i GABAergicznych neuronów hamujących. Następnie
rejestrowano postsynaptyczne prądy hamujące i pobudzające, powstające
spontanicznie. Uzyskane wyniki wykazały, że warunkowanie awersyjne nie
spowodowało zmian podstawowych parametrów elektrofizjologicznych komórek
GABAergicznych i glutaminianergicznych. w skrawkach kory pochodzących
z mózgów zwierząt poddanych uprzednio procedurze warunkowania
klasycznego. Wykazano, że warunkowanie klasyczne nasiliło częstotliwość
spontanicznych postsynaptycznych prądów hamujących (sIPSC) rejestrowanych
w komórkach glutaminianergicznych w skrawkach kory pochodzących
z mózgów zwierząt poddanych procedurze warunkowania klasycznego.
W przeciwieństwie do tego, nie stwierdzono istotnych zmian w częstotliwości spontanicznych postsynaptycznych prądów pobudzających (sEPSC)
rejestrowanych w komórkach GABA i glutaminianergicznych. Wyniki te
potwierdzają hipotezę o nasileniu przekaźnictwa synaptycznego w połączeniach
pomiędzy interneuronami GABAergicznymi a neuronami pobudzającymi,
powstającym w efekcie treningu.
Zaobserwowane nasilenie przekaźnictwa GABAergicznego stanowi,
prawdopodobnie, wyraz adaptacyjnej modyfikacji sieci neuronalnej połączeń
pomiędzy neuronami baryłki, której sens polega na zapewnieniu niezbędnej
równowagi pomiędzy przekaźnictwem pobudzającym a hamującym
w zmienionych warunkach, związanych z awersyjnym warunkowaniem
klasycznym. Mechanizm zaobserwowanych zmian nie jest znany i wymaga
dalszych badań.
Cardiotoxicity of immunotherapy in lung cancer in light of new ESC guidelines
Authors: Orzeł Gabriela B. , Łydka Maciej , Lewandowska Justyna , Stachowiak Julia , Szymańska Ewelina , Mizia-Stec Katarzyna
Published: August 2023

Obserwuje się dynamiczny rozwój terapii przeciwnowotworowej z udziałem przeciwciał monoklonalnych ukierunkowanych na odpornościowe punkty kontroli odpowiedzi immunologicznej. Jednym z nich jest pembrolizumab (humanizowane przeciwciało skierowane przeciwko receptorowi programowanej śmierci komórki 1 – anty-PD-1), stosowany w leczeniu m.in. czerniaka złośliwego, niedrobnokomórkowego raka płuc czy potrójnie ujemnego raka piersi. Przedstawiony w niniejszej pracy przypadek kliniczny dotyczy pacjenta chorującego na raka gruczołowego płuca z licznymi przerzutami oraz chorobami towarzyszącymi. W trakcie immunoterapii pembrolizumabem rozpoznano ostre zapalenie mięśnia sercowego. Przebieg kliniczny tej choroby w sposób szczególny wskazuje na to, jak istotna u pacjentów onkologicznych leczonych immunoterapią jest ciągła ocena i kontrolowanie niepożądanych efektów toksycznych związanych z leczeniem przeciwnowotworowym. Po pierwsze, potencjalna kardiotoksyczność inhibitora PD-1 występuje rzadko u pacjentów poddanych terapii tym lekiem, co znacznie utrudnia precyzyjną diagnostykę różnicową w tym kierunku. Po drugie, ten niepożądany efekt, choć występuje stosunkowo rzadko, często jest śmiertelny. Opisany przypadek wskazuje, w jaki sposób za pomocą wysokich dawek glikokortykosteroidów można skutecznie wyciszać efekty toksyczności wywołanej przez pembrolizumab.
The Effects of Hawthorn (Crataegus oxyacantha) Fruit Extract on Performance, Carcass and Some Serum Parameters of Broilers Reared Under Heat-Stress Conditions[2]
Authors: KAYA Hacer
Published: August 2023

Background: The present experiment was conducted to investigate the effect of heat stress (HS) and hawthorn (Crataegus oxyacantha) fruit extract (HFE) on performance, carcass characteristics and serum parameters in broiler chickens. Methods: Experimental treatments included two different ambient temperatures (24°C: thermoneutral conditions, or 35°C: HS conditions) and three different HFE (0, 0.2 and 0.4 ml/L) in a 2´3 factorial arrangement. A total of 300 1-day-old broiler chicks were randomly allotted 1 of 6 treatments with five replicates. A total of 300 1-day old broiler chicks were randomly allocated to 6 groups with five replications of 10 birds each. HFE supplementation had no effect on growth performance, carcass characteristics and visceral weight in stressed groups (P greater than 0.05). It was also determined that it has a lowering effect on serum malondialdehyde (MDA), free fatty acid (FFA), triacylglyceride (TAG), total lipid (TL) and low density lipoproteins (LDL) (P less than 0.05), but it has no effect on other parameters (P greater than 0.05). Result: As a result, it is thought that the addition of HFE to the drinking water of broiler chickens exposed to HS has no effect on the performance characteristics, HFE has a hypolipidemic effect and would be beneficial in order to strengthen the immune system.
Unpacking ‘Tax Morale’: Distinguishing Between Conditional and Unconditional Views of Tax Compliance
Authors: Prichard Wilson
Published: August 2023

The concept of ‘tax morale’ seeks to capture an individual’s willingness (or unwillingness) to pay taxes. The study of tax morale in lower-income countries is significant for understanding “quasi-voluntary” tax compliance, popular support for tax reform programs, and the broader character of social contracts. While interest in tax morale research has surged over the past decade, the use of the concept in research has often been relatively broad and imprecise. This risks a lack of comparability across studies. More importantly, insufficiently nuanced research risks telling an incomplete or misleading story. As part of a broader effort for greater conceptual precision, this paper highlights the importance of distinguishing between conditional and unconditional understandings of tax morale.
The Actualization of Sustainable Development Goals (SDGs) In Indonesia Economic Growth an Islamic Economic Perspective
Authors: Wartoyo Wartoyo , Haida Nur
Published: August 2023

ABSTRAK
Islamic economics has goals that are aligned with the SDGs, where economic growth mustnot come at the expense of greater things such as environmental damage and human rights.The purpose of this study is to find out how the actualization of the SDGs program oneconomic growth in Indonesia is viewed from an Islamic economic perspective. This researchuses descriptive qualitative methods with literature studies related to theoretical studies andother references related to economic growth. The results of this study conclude that theactualization of the SDGs program in economic growth in Indonesia has not been fullyachieved, even though it has gone on the right track. The indicator is that the efforts so farhave been made aimed at alleviating poverty through fiscal policy accompanied bymobilization of zakat and productive waqaf, reducing unemployment and improvingcommunity welfare through direct assistance programs and business capital assistance.Efforts to preserve the environment have also begun intensively by reclaiming beaches,reforesting forests and reducing the use of fossil fuels through the conversion of conventionalvehicles to electric vehicles. All these efforts are in line with the goals of the SDGs as well asthe goals of the Islamic economy.
Sharia Financial Literacy Index as a Preference in Interest of Saving at Islamic Banks
Authors: Arfatun Arfatun , Tasrif Muh , Alwyah Lila
Published: August 2023

The research aims to describe the potential of the Islamic financial literacy index in increasing people's interest in saving at Islamic Banks in West Nusa Tenggara Province. The method used is descriptive quantitative with a systematic literature review approach. The research findings show that the Islamic financial literacy index has the potential to increase the Islamic financial inclusion index. Islamic financial literacy is specified into high knowledge found in Islamic Banks and Savings is the most recognized product. Those with high Islamic financial literacy are retirees, besides those people with a vulnerable age of 25 years and over and those who work as workers. Areas that have the potential to develop Islamic financial inclusion are Mataram City and North Lombok Regency. This research contributes to providing recommendations to Islamic Banks to be considered for developing Islamic business, as well as topics to be developed in the future.
AN OVERVIEW OF STUDENT’S ANXIETY IN ASSALAFIYAH II MLANGI BOARDING SCHOOL YOGYAKARTA BASED ON AGE AND GENDER
Authors: Farhany Fajrul Falah , Rachmawati Meyka Budi , Ernia Winda , Rahmawati Natasya Putri Imam , Arifah Naily Zahrotun
Published: August 2023

Introduction: Anxiety is a feeling of fear that is unclear and not supported by the situation. When anxious, the individual feels discomfort or fear with no identifiable object. Anxiety disorders are one of the most common psychological disorders in adolescent patients. Every individual is inseparable from anxiety. The anxiety can be mild, moderate, or severe. At school, students also experience anxiety for various reasons, such as anxiety about subjects, anxiety about failing in learning, and others.

Method: This quantitative descriptive study was conducted at the Assalafiyah II Mlangi Islamic Boarding School in July-September 2022. The target population in this study included 840 students using a total sampling technique. Data was collected online with Generalized Anxiety Disorder (GAD) questionnaires.

Result: The results showed significant differences in the level of anxiety based on aged in Assalafiyah II Mlangi Islamic Boarding School (p-value 0.026) and significant results at the level of anxiety based on gender (p-value 0.000).

Conclusion: Female students need more anxiety counseling than male students. Besides that, there was no relationship between age and anxiety. This study assists in developing a strategic plan to reduce anxiety among boarding school students by developing Counseling Guidance Teachers or Psychologists.

Keywords: Mental Health, Anxiety, Islamic Boarding School, Students.
Relationship of Maternal Age and Adverse Childhood Experiences (ACEs) with Traumatic Sequelae in Commercially Sexually Exploited Youth
Authors: Byrnes Kirsten , Han HaeSung , Fujii Kie
Published: August 2023

The impact of early maternal age on several outcomes (e.g. mental health issues, delinquency, aggression, impulsivity, victimization and interpersonal difficulties) has been studied since the late 1980s. Research has demonstrated links between exposure to adverse childhood experiences (ACEs) and trauma related outcomes such as substance abuse, interpersonal and self-directed violence, and sexual risk-taking, to name a few. The current study analyzed the incidence of ACE exposure and mental health outcomes (e.g. suicidal behaviors or self-harm, psychiatric hospitalizations, and substance use) as related to early maternal age in youth known to have experienced trafficking or sexual abuse. General demographics and incidence of various experiences and clinical presentations (e.g. ACE exposure, age of mother at birth of youth and age at first birth), and history of self-harm, substance use and psychiatric hospitalization were examined in a sample of 225 youth referred for services subsequent to experiences of sex trafficking or exploitation. Relationships between ACE exposure and maternal age related to mental health outcomes was also examined. Trafficked and exploited youth reported rates of ACE exposure and poor mental health outcomes at far greater rates than the general population. Significant findings were related to early maternal age and engaging in self-harm or suicidal behaviors. Previously anticipated mediational analyses were not conducted due to the sample size and lack of correlations. Findings highlight the significant ACE exposure and high needs of exploited, trafficked and abused youth and related mental health outcomes, emphasizing the need for early and comprehensive preventive and therapeutic interventions.
Absorption of Light in Vertical III-V Semiconductor Nanowires for Solar Cell and Photodetector Applications
Authors: Anttu Nicklas
Published: August 2023

Vertical III-V semiconductor nanowires have shown promising absorption of light for solar cell and photodetector applications. The absorption properties can be tuned through the choice of III-V materials and geometry of the nanowires. Here, we review recent progress in the design of the absorption properties of both individual nanowires and nanowire arrays. Future directions for the research field are proposed.
Harmonic Graphs Conjecture: Graph-Theoretic Attributes and their Number Theoretic Correlations
Authors: Correa Felipe
Published: August 2023

The Harmonic Graphs Conjecture states that there exists an asymptotic relation involving the Harmonic Index and the natural logarithm as the order of the graph increases. This conjecture, grounded in the novel context of Prime Graphs, draws upon the Prime Number Theorem and the sum of divisors function to unveil a compelling asymptotic connection. By carefully expanding the definitions of the harmonic index and the sum of divisors function, and leveraging the prime number theorem's approximations, we establish a formula that captures this intricate relationship. This work is an effort to contribute to the advancement of graph theory, introducing a fresh lens through which graph connectivity can be explored. The synthesis of prime numbers and graph properties not only deepens our understanding of structural complexity but also paves the way for innovative research directions.
S-nitrosylated Proteins Involved in Autophagy in Triticum aestivum Roots: A Bottom-Up Proteomics Approach and In Silico Predictive Algorithms
Authors: Mazina Anastasia , Shumilina Julia , Gazizova Natalia , Repkin Egor , Frolov Andrej , Minibayeva Farida
Published: August 2023

Autophagy is a highly conserved catabolic process in eukaryotic cells. Reactive nitrogen species play roles as inductors and signaling molecules of autophagy. A key mechanism of NO-mediated signaling is S-nitrosylation, a posttranslational modification (PTM) of proteins at cysteine resi-dues. In the present work we analyzed the patterns of protein S-nitrosylation during the induc-tion of autophagy in Triticum aestivum roots. The accumulation of S-nitrosylated proteins in the cells during autophagy induced by KNO2 and antimycin A was visualized using monoclonal an-tibodies by Western blot analysis, and proteins were identified using a standard bottom-up pro-teomics approach. Protein S-nitrosylation is a labile and reversible PTM, and therefore SNO group can be lost during experimental procedures. Subsequent bioinformatic analysis using predictive algorithms and protein-ligand docking showed that identified proteins possess hypothetical S-nitrosylation sites. Analyzing protein-protein interaction networks enabled us to discover the targets that can directly interact with autophagic proteins, and those that can interact with them indirectly via key multifunctional regulatory proteins. In this study, we show that S-nitrosylation is a key mechanism of NO-mediated regulation of autophagy in wheat roots. A combination of in silico predictive algorithms with a mass spectrometry analysis provides a targeted approach for the identification of S-nitrosylated proteins.
Comparison of the Efficiency of Ultrafiltration, Precipitation, and Ultracentrifugation Methods for Exosome Isolation
Authors: Ansari Farshid Jaberi , Tafti Hossein Ahmadi , Amanzadeh Amir , Rabbani Shahram , Shokrgozar Mohammad Ali , Heidari Reza , Behroozi Javad , Uversky Vladimir N. , Ghanbari Hossein
Published: August 2023

Extracellular vesicles (EVs) are enclosed by a lipid-bilayer membrane and secreted by all types of the cells under various physiological conditions. EVs play important roles in intercellular communication and crosstalk between tissues in the body. They are classified into three groups, such as apoptotic bodies, microvesicles, and exosomes. Exosomes were isolated from biofluids including blood, urine, milk, and cell culture media. Exosomes have significant potential for drug delivery and diagnosis. However, the method of isolation affects the physical and biological properties of exosomes. Several methods based on different principles have been developed for exosome isolation. These include ultrafiltration, precipitation, ultracentrifugation, size-exclusion chromatography, and microfluidics. In this study, we applied three common methods, such as ultrafiltration, precipitation, and ultracentrifugation, to isolate exosomes from the cell culture medium and investigated the effects of these different isolation methods on the size distribution and quality of the isolated exosomes. Field emission scanning electron microscopy (FESEM) images, size distribution, total protein content, and the effect of exosomes on the viability of hypoxic cells were analyzed in this study. The analysis revealed that compared to other methods, the ultracentrifugation method can isolate exosomes with smaller diameter (ranging from 20 to 80 nm), lower total protein content (50 µg/ml), and causing the increased viability of the hypoxic cells. The precipitation method does not require special equipment and is inexpensive, if the quality and purity of this method are solved, and it can be used as the best method for exosome isolation. This study can serve as a guide for choosing the best exosome isolation method for applications in medicine according to the needs, time, cost, and equipment.
Effects of Maternal Stress on Breast Milk Production and the Microbiota of Very Premature Infants
Authors: Fernández_tuñas Carmen , Pérez-Muñuzuri Alejandro , Trastoy-Pena Rocío , Pérez del Molino María Luisa , Couce María Luz
Published: August 2023

Perinatal stress experienced by mothers of very premature newborns may influence the mother’s milk and the infant’s intestinal microbiota. This prospective study of mothers of very preterm infants fed with mother´s own milk (MOM) was carried out in a tertiary hospital over a 2-year period. Assessment of maternal stress in 45 mothers of 52 very preterm newborns using the parental stress scale (PSS:NICU) that revealed an inverse relationship between stress and MOM production in the first days of life (p=0.012). The greatest contributor to stress was the one related to the establishment of mother-child bond. Maternal stress was lower in mothers in whom the kangaroo method was established early (p=0.011) and in those with a higher educational level (p=0.032). Levels of fecal calprotectin (FC) decrease with the passage of days and were directly correlated with birthweight (p=0.044). FC levels 7 days post-delivery were lower in newborns that received postnatal antibiotics (p=0.027). High levels of maternal stress resulted in progressive decreases and increases in the proportions of Firmicutes and Proteobacteria species, respectively, over 15 days post-delivery, both in MOM and in fecal samples from premature newborns. These findings underscore the importance of recognizing and appropriately managing maternal stress in neonatal units, given its marked influence on both the microbiota of maternal milk and the intestinal microbiota of premature newborns.
Cissus antractica -ZnO NPs Induce Apoptosis in A549 Cells through ROS-Mediated p53/Bcl-2/Bax Signaling Pathways and Inhibit Inflammatory Cytokines
Authors: Rupa Eshrat Jahan , Nahar Jinnatun , Al-amin Md. , Park Jin-Kyu , Murugesan Mohanapriya , Awais Muhammad , Lee Seung Jin , Kim Il Mun , Yang Deok Chun , Yang Dong Uk , Jung Seok-Kyu
Published: August 2023

Green products have excellent potential for discovering and producing new medicinal products. In recent years, there is a growing interest towards the green synthesis of metal nanoparticles, particularly from plants sources. This eco-friendly approach was used in the recent research to biosynthesize zinc oxide nanoparticles (ZnO NPs) from Cissus antractica plant. The present study aims to examine the cell cytotoxicity, cell death, and pathways of apoptosis in lung cancer cells (A549) and inflammation properties treated with biosynthesized ZnO NPs. Additionally, synthe-sized ZnO nanoparticles were characterized using UV–vis spectroscopy, X-ray diffraction (XRD), Transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FT-IR), and Energy-dispersive X-ray spectroscopy (EDS). The XRD and TEM analyses exhibited 31 nm as the size of synthesized nanoparticles, the pure crystal form of ZnO NPs, and the shape of the NPs as nearly spherical and hexagonal quartzite. The MTT assay used for cytotoxicity evaluation de-picted the significant toxic effect of CA-ZnONPs against the A549 lung cancer cells at concentra-tions up to 20 µg/mL than non-cancerous cells. Furthermore, we observed an elevated ROS level in cancer cells. These NPs also demonstrated dose-dependent ability to suppress colony for-mation and cell migration, which increases their potential as a lung cancer treatment. Further-more, The NPs formulation's ability to induce apoptosis in cancer cells was further supported by Hoechst and propidium iodide dye. Further, CA ZnO NPs increased the gene expression of BAX, Cyto-c, Caspase 3 and 9, but decreased the expression of Bcl-2, indicating that the nanoformulation triggered mitochondrial-mediated apoptosis. Besides, this study showed that NPs suppressed in-flammatory responses by subsequently decreasing reactive oxygen species (ROS) generation, downregulating the expression of the pro-inflammatory cytokines TNF-α, iNOS, COX-2, IL-6, IL-8, and NO. Moreover, the study's findings imply that Cissus antractica are a potential source with biosynthesize nanoparticles that can might be further investigated for the progress of an-ti-inflammatory and anti-cancer drugs with further study.
The Ecophysiology of Abiotic Stress Determines Plants' Epigenetic Memory and Intelligent Behaviour
Authors: Rai Avinash Chandra , Rai Ved Prakash , Singh Prashant Kumar
Published: August 2023

Unlike animals, persistent dynamic environmental perturbations threaten plants, as they are sessile. Plants keep an inbuilt database of all epigenetic episodes during their lifetime. Present knowledge for exploiting information about how the gene network of plants contributes to epigenetic memory needs to be improved, and extensive in-depth studies are needed. Data from epigenetic memories imparts intelligent behaviour to plants, and these memories can be decoded further to investigate how these plants respond when the same abiotic stress recurs. The epigenetic phenomenon refers to gene expression patterns, including vital factors such as nucleic acids (small ribonucleic acids), histones modelling and methylation of DNA. These changes are cell cycle-associated events that may be transmitted to successive generations. Epigenetic memories due to abiotic stress are necessary for maintaining healthy ecophysiological behaviour of plants and impart the tendency to resist and adapt to challenging environmental conditions. These intelligent memories can be stored and interpreted to prepare for future challenges.
Evading Quantum Mechanics á la Sudarshan: Quantum-Mechanics-Free Subsystem as a Realization of Koopman-Von Neumann Mechanics
Authors: Silagadze Zurab K.
Published: August 2023

The notion of quantum-mechanics-free subsystem (QMFS) was introduced by Tsang and Caves in 2012. They showed that it is possible to design the dynamics of coupled quantum systems in such a way that one can construct a subsystem in which a given classical dynamics is realized, thus avoiding the measurement back-action of quantum mechanics. Although they mention that the Heisenberg picture equations of motion for QMFS was first proposed by Koopman in 1931 as a formulation of classical Hamiltonian dynamics in Hilbert space, in fact the connection between QMFS and Koopmann-von Neumann mechanics is deeper. Namely, quantum-mechanics-free subsystem is nothing but the realization of Sudarshan's perspective on the Koopman-von Neumann mechanics.
Regional Differences in Willingness to Pay for Mitigation of Air Pollution from Coal-Fired Power Plants in South Korea
Authors: Li Dmitriy , Rishi Meenakshi , Bae Jeong Hwan
Published: August 2023

This study examined if people who reside in different regions of South Korea exhibit different WTP for the mitigation of PM2.5 emissions from coal power plants by restricting the operation of such plants during the winter and spring when air pollution becomes severe. A contingent valuation method combined with a double bounded dichotomous choice was used to derive people’s WTP for the mitigation of PM2.5 emissions. Sample group was divided into central, western, eastern, and southern regions. It is known that the eastern region is affected by northwesterly winds in the winter and spring seasons, so air pollutants in the eastern areas fly to the eastern sea. According to the estimation results, respondents who live in eastern regions showed significantly lower WTP than the average WTP. We suggest that the mitigation policy on PM2.5 emissions should consider regional differences in the contributions of coal power plants to PM2.5 emissions.
Unveiling a Biomarker Signature of Meningioma: the Need for a Panel of Genomic, Epigenetic, Proteomic, and RNA Biomarkers to Advance Diagnosis and Prognosis
Authors: Halabi Reem , Dakroub Fatima , Haider Mohammad Z. , Patel Stuti , Amhaz Nayef A. , Reslan Mohammad A. , Eid Ali H. , Mechref Yehia , Darwiche Nadine , Kobeissy Firas H. , Omeis Ibrahim , Shaito Abdullah
Published: August 2023

Meningiomas are the most prevalent primary intracranial tumors. The majority are benign but can undergo dedifferentiation in grades classified from I to III. Meningiomas tremendous variability in tumor behavior and slow growth rates complicate their diagnosis and treatment. A deeper comprehension of the molecular pathways and cellular microenvironment factors implicated in meningioma survival and pathology is needed. This review summarizes the known genetic and epigenetic aberrations involved in meningioma, with a focus on Neurofibromatosis type 2 (NF2) and non-NF2 mutations. Novel potential biomarkers for meningioma diagnosis and prognosis are also discussed, including epigenetic-, RNA-, and protein-based markers. Finally, the landscape of available meningioma-specific animal models is overviewed. Use of these animal models can enable planning of adjuvant treatment, potentially assisting in preoperative and postoperative decision-making. Discovery of novel biomarkers will allow more precise meningioma grading, including meningioma identification, subtype determination, and prediction of metastasis, recurrence, and response to therapy. Moreover, these biomarkers may be exploited in the development of personalized targeted therapies that can distinguish between the 15 diverse meningioma subtypes.