bluuebunny/crossref_metadata_2025 huggingface dataset:
DEVELOPING AN ONLINE PRACTICUM EVALUATION MANAGEMENT SYSTEM
Authors: Osman Baharudin , Uddin Md Rayhan , A/l Sop Chit Suwannit Chareen Chit , Rahmat Abdul Razak , Abuzaraida Mustafa Ali
Published: November 2023

Technology and online systems were enhancing the way people work. An online system for evaluating practicum students is vital as the number of students participating in practicum sessions each semester continues to grow. The traditional method of manual evaluation can be time-consuming and tedious for supervisors, and maintaining and organising student evaluation data can also be a challenge for the university. To overcome these issues, this study aims to create an online evaluation system named "Online Practicum Evaluation Management System". This system will enable supervisors to evaluate students quickly and easily based on the specific rubric without needing to be paper-based. Additionally, the system will provide a secure and organised platform for storing and accessing student evaluation data. This solution aims to enhance the overall efficiency and effectiveness of the practicum program. Rapid Application Developments (RAD) has been used in developing this system. There are four steps in the RAD methodology: requirements gathering, user design, construction, and cutover. Interviews and content analysis were first used to gather the functional requirements. The collected requirements were then used to create a prototype and put through a recorded usability study. The evaluation indicated that OPEMS is practical and straightforward to operate. A majority of respondents are pleased with the system's features. Researchers and developers in this field can use the study as a blueprint for creating similar designs or improving the performance of existing ones. Therefore, the proposed Online Practicum Evaluation Management System will be a more practical, well-organized, faster, reliable, and accurate means of processing the current conventional method of evaluating practicum students.
ATLANTIC SPATIAL: a dataset of landscape, topographic, hydrologic and anthropogenic metrics for the Atlantic Forest
Authors: Vancine Maurício , Niebuhr Bernardo , Muylaert Renata , Oshima Júlia , Tonetti Vinicius , Bernardo Rodrigo , Alves Rafael , Zanette Eduardo , Souza Victor , Giovanelli João , Grohmann Carlos , Galetti Mauro , Ribeiro Milton
Published: November 2023

Space is one of the main drivers of biodiversity, once it regulates the underlying processes affecting the distribution and dynamics of species. It is a fundamental factor in face of the rapid climate and land use and land cover changes at local and global scales, which are linked to habitat loss and fragmentation and their impacts on various organisms. The Atlantic Forest of South America (AF) is among the global biodiversity hotspots because of its high species richness and endemism. Most of the threats to the AF biodiversity is due to the expansion of urbanization and industry, extensive agricultural and livestock production and mining. Here, we make available integrated and fine-scale spatial information (resolution = 30 m) for the entire AF extent for the year 2020. The metrics consider different vegetation classes (forest and forest plus other natural vegetation), effects of linear structure (roads and railways) and multiple scales (radius buffer from 50 m to 2,500 m and up to 10 km for some metrics). The entire data set is composed of 500 rasters and the AF delimitation vector, available through the R package atlanticr, which we developed to facilitate the organization and acquisition of the data. The metrics consists of land cover (31 classes), distance to grouped land cover classes (forest vegetation, natural vegetation, pasture, temporary crop, perennial crop, forest plantation, urban areas, mining and water), a set of landscape, topographic and hydrologic metrics and anthropogenic infrastructure. The landscape metrics include landscape morphology (classification as matrix, core, edge, corridor, stepping stone, branch and perforation), fragment area and proportion, area and number of patches, edge and core areas and proportion, structural and functional connectivity (for different organisms’ gap-crossing capabilities), distance to fragment edges, fragment perimeter and perimeter-area ratio and landscape diversity. Topographic metrics include elevation, slope, aspect, curvatures and landform elements (peak, ridge, shoulder, spur, slope, hollow, footslope, valley, pit and ﬂat), hydrologic metrics comprise potential springs and its kernel and potential streams and respective distances and anthropogenic infrastructure maps contain roads, railways, protected areas and indigenous territories and the respective distance to each of them. These data sets will allow for efficient integration of biodiversity and environmental data for the AF in future ecological studies, and we expect it to be an important reference and data source for landscape planning, biodiversity conservation and forest restoration programs.
Realismo estructural óntico en H.P. Lovecraft
Authors: Arriagada Leonardo
Published: November 2023

Este artículo pretende mostrar que, a través de la obra de Lovecraft, es posible ilustrar una forma de realismo estructural óntico (REO). Se postula que la literatura de Lovecraft permite ejemplificar una ontología orientada hacia las relaciones (entre entidades), y no a las entidades mismas. Además, puesto que en esta forma de REO las entidades se definirían por sus relaciones, se concluye que estas deberían ser abstractas, habilitadas para contar con todas las características que extrínsecamente les sean asignadas en una actualización determinada de la estructura que las alberga.
Vítimas do desejo ou o melodrama latino-americano sem suporte de Cristian Molina
Authors: Correa Joaquín
Published: November 2023

A partir das análises sobre o melodrama desenvolvidas por Jesús MartínBarbero e Carlos Monsiváis, se estuda a produção ficcional / poética recente do professor, crítico, poeta, narrador e performer argentino Cristian Molina, no seu conjunto de heterónimos: Un pequeño mundo enfermo, Machos de campo, Sus bellos ojos que tanto odiaré e Dos poemas sojeros. Apoiando-se no excesso do melodrama, Molina levará à poesia a um espaço que o seu restringido consumo histórico não permitia, aproximando ela ao popular sem, porém, perder nenhum tipo de rigor nem fazer concessão alguma, ficando no terreno, paradoxalmente, do minoritário. Se num primeiro momento, Molina apela ao melodrama para abrir a poesia em direção ao an-aurático, num segundo momento, partirá dessa poesia que performa sua perda de aura para inaugurar uma nova forma do melodrama: o melodrama sem suporte.
Entre la imagen y el texto: ciudad moderna y trabajadores en San Pablo
Authors: Righi Fernanda
Published: November 2023

Siguiendo las ideas Georg Simmel sobre la ciudad moderna, este trabajo analiza la figura del trabajador en San Pablo durante las décadas del 20 y el 30 relacionando el documental São Paulo: sinfonía da metropole de Rodolfo Lustig y Adalberto Kemeny y el cuento “Primero de Maio” de Mário de Andrade.. Por un lado, el documental presenta un trabajador mecanizado, funcional a la productividad estimulada por el estado y el sistema económico. Por otro, en el cuento, el trabajador intenta salir de esta lógica pero no tolera la confusión y regresa a su espacio laboral- familiar de pertenencia. De este modo, el autor demuestra la existencia de vínculos sentimentales desarrollados en el espacio laboral, los cuales, a pesar de oponerse a la lógica capitalista industrial urbana, permiten su funcionamiento.
¿Cómo se escribe una vida retirada? Kafka y sus biografías
Authors: Surghi Carlos
Published: November 2023

El presente trabajo analiza la importancia de la biografía como géneroen la conformación de las diversas figuras de autor que, a lo largo de los años,se han impuesto del escritor Franz Kafka. Para ello estudia la relación entre viday literatura como extremos en tensión a la hora de establecer una figuraciónbiográfica del autor de La metamorfosis. Desde la primera biografía propuestapor Max Brod hasta la reciente de Rainer Stach, pasando por la falsificación y ladesmitificación de diversos ensayistas que atiende a la relación obra-vida,nuestro trabajo expone cómo cada acercamiento propone una mirada sobre lavida de Kafka que, una y otra vez, malogra su principal característica: laposibilidad de rastrear un método compositivo-comparativo que podría pensarsecomo una inteligencia literaria, principal interés de toda escritura biográfica.
Muerte, poder y ficción en Magnetizado, de Carlos Busqued
Authors: Giachetti Bruno
Published: November 2023

En este artículo, analizaremos el singular relato de Ricardo Melogno que propone Magnetizado (2018), de Carlos Busqued, indagando la peculiaridad de su narrativa testimonial en relación con los discursos psiquiátrico-criminológico y con diversos contenidos de la industria cultural que fueran asiduamente consumidos por el protagonista de la historia. Tomando en consideración el análisis foucaulteano acerca del mecanismo confesional de restitución punitiva, indagaremos la configuración narrativa de una matriz de percepción e inteligibilidad que ha obturado la resolución médico-jurídica del caso Melogno, iluminando una suerte de dispositivo de realidad-ficción en el que se entraman lo vivido y lo imaginado, lo presente y lo ausente, la experiencia y la representación. A partir del análisis de la exhibición explícita de la capacidad de dar la muerte como patrón dominante de expansión en la industria del entretenimiento, nos detendremos en el vacío semántico en torno al cual gravitan los crímenes pergeñados por Melogno, abriendo un campo de exploración crítica sobre el concepto de empoderamiento distópico, acuñado por Sayak Valencia (2010) en su abordaje del tejido simbólico profundo -social, cultural y político-, que modela relaciones, sentidos y jerarquías.
Determining the Quintet Lifetimes in Side-ring Substituted [Fe(terpy)2]2+ Complexes
Authors: Vancza Andor , Kapta Marcell Levente , Papp Mariann , Vankó György , Keszthelyi Tamás
Published: November 2023

We previously studied the effect of 4' substitution in iron(II)-bis-terpyridine complexes, showing that the photoexcited high-spin quintet-state is stabilized by electron-donating substituents. In this paper we explore the effects of electron-donating ( X = NH2 , Cl ) and withdrawing ( X = NO2 ) substituents in the 5,5" positions on the stability and lifetime of the quintet-state. We used a simple densitiy-functional theory (DFT) based method that had been proven fairly accurate in the case of 4' substitution to estimate the energy barrier of the quintet-singlet transition and thereby predict the quintet state lifetime. We synthetized the complexes and used ultrafast transient optical absorption spectroscopy to experimentally determine the quintet lifetimes, in order to test the applicability of these quantum-chemistry based predictive methods for these side-ring substitution cases. UV-Visible spectra of the complexes have shown that the metal-to-li­gand charge transfer (MLCT) and ligand-localized transitions of these complexes change according to the previous observations. We have shown that in the 5,5" positions, electron withdrawing groups stabilize the quintet state, while donating groups destabilize it. This is in stark contrast to the effects previously observed for the 4' case, and indicates that unlike the latter case, the simple concept of inductive and mesomeric effects may not be adequate to describe the changes due to 5,5" substitution, warranting further study of the area.
Vol. 7. No. 3/4 (2023)
Authors: Brochu Leah
Published: November 2023

Cover and credits for volume 7, issue 3/4, Fall, 2023.
A Framework of Excessive Executive Compensation – An Obscured Breach in Corporate Governance Agency Contract
Authors:   University of Limpopo, Polokwane, South Africa, Ngwakwe Collins C
Published: November 2023

Excessive executive compensation is tantamount to a breach of agency contract. There are two main problems with excessive executive compensation: excessive compensation is stealing from a shareholder’s standpoint; excessive executive compensation is demoralizing to the other workers in the organization. Purpose. This paper aims to provide a conceptual framework of the antecedent and postcedent of excessive executive compensation. Approach. The paper inclines on agency theory and the attendant principal-agent contract. The paper follows a critical deconstruction approach, culminating in the development of an original conceptual framework. Finding. Through a critical deconstruction of agency theory postulation of optimal agent’s response to corporate compensation structure, it emerges that this postulation may not hold in all instances given that gargantuan compensation structure has a high propensity to nurture irresistible executive financial misdemeanours to inflate profit or share price, which are the performance index of reaping the excessive compensation. This incubates ancillary agency costs to the detriment of the principal and corporate survival. Theoretical and practical value. The paper offers insight into corporate governance strategy for accounting and business law theory and practice in university business schools and for further research. In addition, corporate boards may draw insights from the theory developed in this paper, which portrays the antecedents and postcedents of executive excessive compensation. This theory will catalyse debate and rethinking of corporate compensation policies within the boards of directors. The paper offers an original contribution to the contentious agency cost issues by developing a conceptual framework of the antecedent and postcedent of excessive executive compensation – depicting obscured additional agency costs.
PERANCANGAN APLIKASI PENGAJUAN KREDIT ONLINEBERBASIS WEBSITE (STUDI KASUS : PT. FINANSIA MULTI FINANCE (KREDIT PLUS)
Authors: Wahyu Ari Purno , Umi Hayati
Published: November 2023

Finansia Multi Finance (Kredit Plus) telah menjadi salah satu pembisnis terkemuka di bidang industri pembiayaan yang tersebar melalui jaringan distribusi pada 244 lokasi di seluruh Indonesia memusatkan bisnisnya pada bidang pembiayaan mobil, motor dan elektronik. Dalam menjalankan usahanya, perusahaan ini senantiasa beradaptasi dengan perkembangan jaman. Kredit adalah penyaluran uang dari pemilik uang kepada yang membutuhkan. Penyaluran dana tersebut didasarkan atas kepercayaan yang dimiliki oleh pemilik dana kepada pengguna dana. Pada kondisi new normal ini banyak pekerjaan yang sudah berbasis online membuat pelanggan tidak perlu datang ke suatu tempat. Oleh sebab itu penulis membuat sistem kredit online berbasis web untuk mempercepat proses transaksi dari manapun, kita hanya harus berbekal internet dan identitas untuk dapat melakukan transaksi online ini. Aplikasi yang telah dirancang dapat menampilkan infomasi terhadap setiap transaksi yang telah dilakukan proses verifikasi oleh admin sehingga konsumen dapat melakukan kredit terhadap barang dengan menggunakan MySQL sebagai database. Aplikasi ini berbasis website yang dapat menampung data konsumen yang telah melakukan transaksi menggunakan metode kredit diharapkan dapat mempercepat proses manajemen data.
STAT5B mutations in myeloid neoplasms differ by disease subtypes but characterize a subset of chronic myeloid neoplasms with eosinophilia and/or basophilia
Authors: Yin C. Cameron , Tam Wayne , Walker Serena M. , Kaur Amandeep , Ouseph Madhu M. , Xie Wei , K.Weinberg Olga , Li Peng , Zuo Zhuang , Routbort Mark J. , Chen Simon , Medeiros L. Jeffrey , George Tracy I , Orazi Attilio , Arber Daniel A. , Bagg Adam , Hasserjian Robert P. , Wang Sa A.
Published: November 2023

STAT5B has been reported as a recurrent mutation in myeloid neoplasms (MNs) with eosinophilia, but the overall frequency and importance across a spectrum of MNs are largely unknown. We conducted a multicenter study on a series of 82 MNs with STAT5B mutations detected by next-generation sequencing. The estimated frequency of STAT5B mutation in MNs was low,
Outbreak of ciguatera poisoning in a commercial vessel: lessons learnt and prospects of early diagnosis, management, and prophylaxis
Authors: Krasnova Svetlana , Smoll Nicolas , Carter Steve , McManus Mark , Kumar Dilip , Khandaker Gulam
Published: November 2023

An outbreak of food poisoning of unknown origin was notified to Central Queensland Public Health Unit on 9 December 2021. The bulk carrier sailing from Higashiharima, Japan to Gladstone, Australia reported an incident of sudden illness, with 19 out of 20 sailors on board reporting a combination of gastrointestinal and neurological symptoms. Central Queensland Public Health Unit started the outbreak investigation as per Queensland Health public health management guidelines. All 20 of the sailors consumed a self-caught barracuda and squid, prepared by the ship’s cook, the day before. Unconsumed samples of the fish and squid were sent for testing. The affected sailors were triaged on arrival and were provided with medical care as required. The barracuda sample contained ciguatoxins (CTXs; P-CTX-1, P-CTX-2, P-CTX-3) with a total count of 3.40 ug/kg confirming the diagnosis. We propose the usage of the combination of gastrointestinal symptoms and paraesthesia in the light of a recent intoxication event for early detection of ciguatera poisoning (CP) in the eastern seaboard of Australia.
Performance Comparison ConvDeconvNet Algorithm Vs. UNET for Fish Object Detection
Authors: Hindarto Djarot
Published: November 2023

The precise identification and localization of fish entities within visual data is essential in diverse domains, such as marine biology and fisheries management, within computer vision. This study provides a thorough performance evaluation of two prominent deep learning algorithms, ConvDeconvNet and UNET, in the context of fish object detection. Both models are assessed using a dataset comprising a wide range of fish species, considering various factors, including accuracy of detection, speed of processing, and complexity of the model. The findings demonstrate that ConvDeconvNet exhibits superior performance in terms of detection accuracy, attaining a noteworthy degree of precision and recall in identifying fish entities. In contrast, the UNET model displays a notable advantage in terms of processing speed owing to its distinctive architectural design, rendering it a viable option for applications requiring real-time performance. The discourse surrounding the trade-off between accuracy and speed is examined, offering valuable perspectives for algorithm selection following specific criteria. Furthermore, this study highlights the significance of incorporating a diverse range of datasets for training and testing purposes when utilizing these models, as it significantly influences their overall performance. This study makes a valuable contribution to the continuous endeavors to improve the detection of fish objects in underwater images. It provides a thorough evaluation and comparison of ConvDeconvNet and UNET, thereby assisting researchers and practitioners in making well-informed decisions regarding selecting these models for their specific applications.
Risk factors of prolonged diarrhea in children under 2 years old
Authors: Rahmat Dedy , Firmansyah Agus , Timan Ina S. , Bardosono Saptawati , Prihartono Joedo , Gayatri Pramita
Published: November 2023

Background: Prolonged diarrhea, defined as diarrhea lasting longer than 7 days, is known to negatively impact children's growth and development. However, studies of the risk factors of prolonged diarrhea remain limited.Purpose: This study aimed to analyze the risk factors for prolonged diarrhea in children under 2 years of age with acute diarrhea.Methods: This 1-year nested case-control study was conducted at Fatmawati General Hospital in 2021–2022. Participants were selected using a consecutive sampling method from among children under 2 years of age with acute diarrhea within the previous 2–4 days. Children with diarrhea that lasted 7 days were considered positive for prolonged diarrhea, whereas those with acute diarrhea were considered negative. Children with comorbidities such as malnutrition were excluded. Clinical information including age, breastfeeding history, antibiotic exposure history, and nutritional status was recorded. Complete blood count, blood zinc levels, Rotavirus, adenovirus, and norovirus serology, alpha-1 antitrypsin (AAT) levels, and stool analysis were acquired as laboratory data.Results: There were 62 subjects in the study and control groups. Overall, the median age was 12 months (6–24 months); most patients were boys. A history of antibiotic use (odds ratio [OR], 15.860; 95% confidence interval [CI], 5.286–47.591; P<0.001), zinc deficiency (OR, 4.758; 95% CI, 1.711–13.229; P=0.003), and elevated fecal AAT levels (OR, 2.677; 95% CI, 1.046–6.850; P=0.040) were the main risk factors for prolonged diarrhea in children under 2 years of age with acute diarrhea.Conclusion: A history of antibiotic use, zinc deficiency, and elevated fecal AAT levels were the main risk factors for prolonged diarrhea in children under 2 years of age with acute diarrhea. Thorough testing and appropriate antibiotic use are required to prevent prolonged diarrhea in children under 2 years of age.
Metabolic complications of obesity in children and adolescents
Authors: Park Hyunjin , Choi Jung Eun , Jun Seunghee , Lee Hyelim , Kim Hae Soon , Lee Hye Ah , Park Hyesook
Published: November 2023

The global prevalence of childhood and adolescent obesity, exacerbated by the coronavirus disease 2019 pandemic, affects school-aged children and preschoolers. Early-onset obesity, which carries a high risk of metabolic complications, may contribute to a lower age at the onset of cardiovascular disease. As metabolic diseases such as diabetes, dyslipidemia, and nonalcoholic fatty liver disease observed in adulthood are increasingly recognized in the pediatric population, there is an emphasis on moving disease susceptibility assessments from adulthood to childhood to enable early detection. However, consensus is lacking regarding the definition of metabolic diseases in children. In response, various indicators such as the pediatric simple metabolic syndrome score, continuous metabolic syndrome score, single-point insulin sensitivity estimator, and fatty liver index have been proposed in several studies. These indicators may aid the early detection of metabolic complications associated with pediatric obesity, although further validation studies are needed. Obesity assessments are shifting in perspective from visual obesity to metabolic health and body composition considerations to fill the gap in health impact assessments. Sarcopenic obesity, defined as the muscle- to-fat ratio, has been proposed in pediatric populations and is associated with metabolic health in children and adolescents. The National Health Screening Program for Children in Korea has expanded but still faces limitations in laboratory testing. These tests facilitate timely intervention by identifying groups at a high risk of metabolic complications. Early detection and intervention through comprehensive health screening are critical for mitigating long-term complications of childhood obesity.
Enhancing the Value of Bajing Coffee: A Branding Training and Assistance at Girimoyo Village
Authors: Wibowo Novin Farid Styo , Nasvian Moch Fuad , Bhakti Aditya Dwi Putra , Widiatmojo Radityo
Published: November 2023

One of the sectors that contribute to the Indonesian economy is agriculture, forestry, and fishery with around 13.28% of the Gross Domestic Product (GDP). Among them, coffee is known to be one of the essential commodities. Girimoyo village, one of the known coffee producers in Malang Regency, has a special coffee product called Bajing Coffee. Pamanjur Coffee Processor, one of the coffee production businesses, wants to make Bajing Coffee more popular. However, Pamanjur Coffee Processor fails to recognize the consumer and that makes the business grow slowly. Hence, Pamanjur Coffee Processor needs to raise people’s awareness of their products by methods that suit youngsters, especially through appealing social media content. As a result, this community service aims at helping Pamanjur Coffee Processor to gain more awareness. This community service program uses several methods, assessment, training, and assistance. The result shows that Pamanjur Coffee Processor did not have the “energy” to spend on the branding process of Bajing Coffee, but all the skills provided by the community service team are used to develop the identity and promotion of their cafe business line. As a result, this community service program was successful at the skill transfer level but failed to increase the branding of Bajing Coffee.
Reputation effects in peer-to-peer online markets: meta-analyses and laboratory experiments
Authors:   , Jiao Ruohuang
Published: November 2023

The commonly used reputation systems in online markets facilitate establishing trust in a potential transaction partner who is often anonymous and geographically distant. Successful transactions will only take place when sellers and buyers trust each other, and a good reputation from previous experience will induce such mutual trust and lower the risks for both parties. In this dissertation, we used meta-analytic methods to synthesize evidence from over a hundred empirical studies to affirm the general existence of reputation effects and explored various potential moderators to explain the variation in reputation effects. Moreover, we argued that the effectiveness of a reputation system may not necessarily be that reputable sellers always earn a large price premium, but rather due to the system’s ability to attract and maintain a majority of trustworthy and reliable sellers, reputation will be less important.
Transformative Government
Authors:   , Braams Rik Bastiaan
Published: November 2023

Many articles on transition highlight the urgent need for radical change, citing e.g. the Paris
Climate Agreement, the Green Deal, IPCC reports, and the EU’s focus on societal missions
and grand societal challenges (Janssen et al., 2022; Wanzenböck et al., 2020). Economists, philosophers, spiritual leaders, and mobility experts have also emphasized this urgency. Their broad-based existential unwillingness to accept the consequences of the climate crisis in all its facets demonstrates a search for a new sustainable equilibrium achieved only by system change. The overarching goal of this thesis is therefore to find a legitimate rationale and favorable institutional structures for the civil service, to support governments in facilitating guiding sustainability transitions.
To achieve this goal, this thesis examines the tasks assigned to governments by transition
scholars through the lens of Public Administration (Chapter Two), institutional acceptance of these tasks (Chapter Three) and tactical patterns of entrepreneurial civil servants executing these tasks (Chapter Four). Additionally, practitioners’ ideas for new institutional configurations to execute transition plans are explored (Chapter Five). I conclude that a new Public Administration tradition is needed to facilitate civil servants to execute transition tasks. With this aim, this dissertation introduces the concept of Transformative Government to legitimize transformative change for civil servants.
This research aims to identify a legitimizable transition rationale for governments, incorporating both Transition Literature and Public Administration concepts. The current Public Administration traditions, that legitimize or delegitimize the actions of civil servants, are incompatible with system change. This thesis proposes a new rationale, called transformative Government, which connects sustainability transitions to accepted legitimacy claims from Public Administration. In practice, this means that the Transformative Government understands, accepts, and implements transition tasks based on a new normative framework. This rationale provides a new Public Administration
tradition that prescribes and legitimizes actions needed for transition. It synthesizes notions of system change, administrative processes, legitimacy, and democracy to enable a legitimized pursuit of transition tasks.
For this rationale to become a Public Administration tradition in the near future, it needs to
be grounded in Public Administrative philosophy and theory. This thesis outlines some contours of this tradition following the comparative criteria set out by Stout (2013). A new tradition is needed when all existing traditions hinder systematic change to the point that inertia follows. The Transformative Government provides a new perspective to governments experiencing a systematic lock-in, producing an impossibility of working on systematic, sustainable change.
FORMULASI LIP BALM EKSTRAK LIDAH BUAYA (ALOE VERA) DAN BUAH NAGA MERAH (HYLOCEREUS POLYRHIZUS) SEBAGAI PELEMBAB BIBIR
Authors: Tampubolon Antetti
Published: November 2023

Lip balm is a cosmetic preparation with main components such as waxes, fats and oils. The purpose of this study was to determine whether Aloe vera and red dragon fruit extracts could be formulated as moisturizers and natural dyes in lip balm preparations. The study was carried out experimentally, including the formulation of preparations with concentrations of Aloe Vera extract 3%, 6%, 10%, and Red Dragon Fruit extract 3%, 5%, 7%. Examination of the physical quality of the preparation, namely homogeneity test, stability during 28 days of storage at room temperature, melting point, pH, and preference test. The results showed that (F1) with a concentration of 3% aloe vera and 3% red dragon fruit met the requirements for homogeneity, melting point, pH, and stability tests, on (F2) with a concentration of 6% aloe vera and 5% red dragon fruit does not meet the requirements of the pH test, but meets the requirements of the homogeneity test, melting point test, and stability test. Whereas for (F3) with a concentration of 10% aloe vera and 7% red dragon fruit did not meet the homogeneity and pH test requirements, but met the melting point and stability test requirements. It can be concluded that Aloe Vera Extract and Red Dragon Fruit can be formulated into lip balm dosage forms. Differences in concentration variations can affect the moisture on the skin and the color of the preparation.
ANALISA PERESEPAN DAN INTERAKSI KOMBINASI DUA MACAM ANTIBIOTIK INTRAVENA DI RUMAH SAKIT X TANGERANG SELATAN
Authors: Chusun Chusun , Retno Fitriani , Yosep Fauzi
Published: November 2023

One of the mainstay drugs to treat infections is antimicrobials, including antibacterials/antibiotics, antifungals, antivirals and antiprotozoa. Antibiotics are drugs used in infections caused by bacteria. Antibiotics that are not used wisely can lead to resistance problems. Therefore, the use of antibiotics must follow a rational strategy of prescribing antibiotics. Irrational prescribing will increase the occurrence of drug side effects, drug interactions, medical costs and result in decreased patient compliance in taking drugs.
      The purpose of this study was to determine the pattern of prescribing combinations of intravenous antibiotics in one prescription sheet and their interactions.
This research is a type of quantitative research, with descriptive methods and using retrospective data. The population in this study were all prescription sheets of inpatients who had been served at the X  Hospital Pharmacy Installation for the period January 1 to March 31, 2021. The samples were all prescription sheets containing a combination of 2 (two) intravenous antibiotics (injection or infusion), all of which totaling 170 sheets.
     The results showed that there were more male patients than female patients, namely 52.3% with the largest age range between 46-55 years (29.41%). Of the 15 combinations of 2 (two) intravenous antibiotics, there were 6 combinations that had moderate pharmacodynamic interactions. Moderate interactions are clinically significant, usually avoided in combination or used only in special circumstances and with close monitoring of health workers. Of the 170 prescription sheets, 135 sheets (79.4%) were prescribed by internal medicine specialists. All intravenous antibiotics prescribed according to the X  Hospital Formulary and the National Formulary.
PEMANFAATAN LIMBAH KULIT BAWANG PUTIH (Allium sativum L.) SEBAGAI BAHAN AKTIF PEMBUATAN SABUN CAIR
Authors: S Panji Ratih , R Sih Wahyu , Fitriyany Erna , I Cikra , Calya Finna , Sari Septiana
Published: November 2023

Utilization of household waste in Indonesia is still very rarely done, one of which is the use of garlic skin waste. From research by Allemann & Baumann in 2008, garlic skin is rich in antioxidant compounds so it can protect skin cells from free radical damage if used as a skincare product, one of which is liquid bath soap for the body. This research aims to formulate garlic skin extract as liquid soap. The concentration used is 10%. The liquid soap formulation used was 17 g of SLS, 3 g of NaCl, 9 g of Cocamidopropyl Betaine, 9 g  of Glycerin, Fragrances, and Dyes to taste. Garlic skin extract liquid soap is evaluated for its physical quality consisting of organoleptic test results in the form of liquid, gum-scented and red-colored, pH test of 8.2, height test and foam stability of 79 mm, moisture content test of 51.12%, specific gravity test of 1.012 g/ml, and irritation test declared non-irritating. The results showed that garlic skin extract liquid soap with a concentration of 10 % had a physical quality that complied with their requirements. This research concludes that garlic skin extracts liquid soap meets the requirements of the physical quality test and safe for the skin because it does not cause irritation to the skin when used.
GAMBARAN EFEKTIFITAS PENERAPAN 5 STANDAR OPERASIONAL PROSEDUR (SOP) PELANGGAN DI PBF BINA PRIMA SEJATI JAKARTA BARAT
Authors: Brahmono Angga , Saragi Sahat , Andayani Nurita
Published: November 2023

The CDOB guidelines state that in implementing CDOB, one must have an SOP. SOP formulation as a benchmark in assessing the effectiveness and efficiency of agency performance in implementing its work program. The principle of preparing SOPs must also be oriented to the parties served so that they can provide satisfaction to users. It is important for PBF to pay attention to the quality of services provided to pharmacies because it can lead to satisfaction and a positive attitude from customers. The purpose of this study was to determine the effectiveness of implementing 5 customer SOPs at PBF Bina Prima Sejati. The method used in this research is descriptive method with observation. The results of the study showed that the results of the SOP for distributing drugs to new pharmacies were 93.65% carried out by officers; SOP for handling customer complaints has only been implemented 43.81%; SOP for handling counterfeit and suspected counterfeit drugs has only been implemented 80.47%; The SOP for handling new returned drugs was 98.64% carried out by officers and the SOP for handling new recalled drugs was 89.68% carried out by officers. Overall 5 SOPs related to new customers 81.25% are carried out by officers. If it is seen that the effective implementation of the SOP must be 100%, then the implementation of the 5 customer SOPs is not effectively carried out by officers.
FORMULASI KAPSUL ANTIDIABETES EKSTRAK UMBI BAWANG DAYAK (Eleuhterine palmifolia (L) Merr.) DENGAN VARIASI KONSENTRASI AVICEL 101 DAN PREGELATINIZED STARCH
Authors: Indriawan Kadek Agus , Sa'adah Hayatus , Helmidanora Rusdiati
Published: November 2023

Diabetes Mellitus is a heterogeneous disease characterized by improvement glucose levels in the blood. Several studies have shown that Dayak onions have hypoglycemic activity or lowering blood glucose levels which may be very useful for treatment of diabetes mellitus. Flavonoids contained in Dayak onions are in position to restore the characteristics of pancreatic tissue by increasing insulin release through β cells, so that it can lower blood sugar levels and can also increase sensitivity peripheral cells to insulin. Given the great potential of Dayak onions as antidiabetic, it is very important to develop more practical preparations that can carrying out weight uniform measurements of the products used, of course, one of them is in pharmaceutical preparations capsule form. This examination aims to determine the physical properties and antioxidant activity of Dayak onion extract capsules in large quantities concentration of Avicel PH 101 and pregelatinized starch as fillers. Look was carried out experimentally using three formulas with various concentrations fillers with a ratio between Avicel PH 101 and pregelatinized starch, in particular formula I (1:0), formulation II (0.5:0.5) and method III (0:1). body residence and drug stability is checked and then tested for antioxidant hobby spectrophotometric use. The research results show that the formula with the composition of Avicel PH 101 and pregelatinized starch in the ratio (0:1) is given the best wet house physical test results were 3.4%, sliding houses 12.82 gram/second, angle of repose 29.85⁰, compressibility 8%, density 0.544 and destroyed time 3 minutes 37 seconds. along with antioxidant effects activity examination showed that the drug Dayak onion extract proved to be moderate antioxidant activity, specifically 228.78 ppm.
Pencapaian dan Peningkatan Kemampuan Berpikir Kritis Siswa Kelas VIII SMP Melalui Pendekatan Pendidikan Matematika Realistik
Authors: Trivonia Bau Anastasia , Loka Son Aloisius , Patricia Wua Laja Yosepha
Published: November 2023

The aim of this study was to compare the achievement and improvement of students' critical thinking skills through realistic mathematics education approaches and conventional learning. This study uses a quantitative method with a quasi-experimental approach. The research design used a pretest-posttest control group design. The experimental group learning used the PMR approach and the control group used conventional learning. This study was conducted in October 2022. The participants in this study were students of class VIII of a junior high school in Belu district. The sample in this study was 50 students consisting of two classes, each class consisting of 25 students. The research instrument was in the form of critical thinking ability tests and learning implementation observation sheets. Analysis of achievement data and improvement of necessary thinking skills using the Independent Samples t-test. The results of the study show that the achievement and improvement of students' mathematical necessary thinking skills who learn through a realistic mathematics education approach are better than students who learn with conventional approaches. This shows that learning with a realistic mathematics education approach can facilitate junior high school students critical thinking abilities
Meningkatkan Aktivitas dan Hasil Belajar Matematika melalui Penerapan Model Learning Cycle 5E Berbantuan Tutor Sebaya
Authors: Widyastiti Rupita , Widana I Wayan
Published: November 2023

Penelitian tindakan kelas ini bertujuan untuk meningkatkan aktivitas dan hasil belajar matematika melalui penerapan model Learning Cycle 5E berbantuan tutor sebaya. Subjek penelitian ini adala peserta didik kelas X-2 SMA Negeri 1 Kuta Utara Tahun Pelajaran 2022/2023 yang terdiri dari 40 orang. Objek penelitian ini adala aktivitas dan hasil belajar matematika. Data penelitian dianalisis secara deskriptif kualitatif. Kriteria keberhasilan penelitian ini yaitu: (a) meningkatnya persentase aktivitas dan hasil belajar peserta didik dari siklus I ke siklus II; (b) terdapat minimal 80% dari jumlah peserta didik aktivitas belajar matematika dalam kategori aktif dan sangat aktif; dan (c) terdapat minimal 75% dari jumlah peserta didik nilainya lebih atau sama dengan 70 dalam kategori tuntas. Hasil penelitian ini menunjukkan: (a) tercapainya peningkatan aktivitas dalam kategori aktif dan sangat aktif pada siklus I sebesar 57,5% menjadi 85% pada siklus II; (b) meningkatnya ketuntasan hasil belajar peserta didik yang pada prasiklus sebesar 20%, pada siklus I meningkat menjadi 55%, dan pada siklus II mencapai 90%. Kesimpulan model Learning Cycle 5E berbantuan tutor sebaya mampu meningkatkan aktivitas dan hasil belajar matematika peserta didik.
Nanotechnologies for the detection and treatment of endometriosis
Authors: Sahni Maneesha , Day Emily S.
Published: November 2023

Endometriosis is an incurable gynecologic disease characterized by endometrial-like tissue growth outside of the uterine cavity. It affects approximately 10% of reproductive age women, who endure pelvic pain during periods and/or sexual intercourse and who suffer from reduced fertility and diminished quality of life due to the side effects of current treatments. To improve the management and prognosis of endometriosis patients, researchers have recently begun to develop nanoparticle-based diagnostics and treatments that are more effective and less invasive than existing approaches. This review discusses the current state of the field and highlights considerations for the continued development of nanotechnologies for the diagnosis and treatment of endometriosis.
Phenotype plasticity and altered sensitivity to chemotherapeutic agents in aggressive prostate cancer cells
Authors: Paxson Allan I. , Chang Loren H. , Gard Jaime M. C. , Harryman William L. , Nelson Colin S. , Salmon Stella B. , Marr Kendra D. , Wachsmuth Leah M. , Ramanathan Anita , Ran Jing , Kapoor Abhijeet , Marugan Juan J. , Henderson Mark J. , Sanchez Tino W. , Cress Anne E.
Published: November 2023

In 2023, approximately 288,300 new diagnoses of prostate cancer will occur, with 34,700 disease-related deaths. Death from prostate cancer is associated with metastasis, enabled by progression of tumor phenotypes and successful extracapsular extension to reach Batson’s venous plexus, a specific route to the spine and brain. Using a mouse-human tumor xenograft model, we isolated an aggressive muscle invasive cell population of prostate cancer, called DU145J7 with a distinct biophysical phenotype, elevated histone H3K27, and increased matrix metalloproteinase 14 expression as compared to the non-aggressive parent cell population called DU145WT. Our goal was to determine the sensitivities to known chemotherapeutic agents of the aggressive cells as compared to the parent population. High-throughput screening was performed with 5,578 compounds, comprising of approved and investigational drugs for oncology. Eleven compounds were selected for additional testing, which revealed that vorinostat, 5-azacitidine, and fimepinostat (epigenetic inhibitors) showed 2.6-to-7.5-fold increases in lethality for the aggressive prostate cancer cell population as compared to the parent, as judged by the concentration of drug to inhibit 50% cell growth (IC50). On the other hand, the DU145J7 cells were 2.2-to-4.0-fold resistant to mitoxantrone, daunorubicin, and gimatecan (topoisomerase inhibitors) as compared to DU145WT. No differences in sensitivities between cell populations were found for docetaxel or pirarubicin. The increased sensitivity of DU145J7 prostate cancer cells to chromatin modifying agents suggests a therapeutic vulnerability occurs after tumor cells invade into and through muscle. Future work will determine which epigenetic modifiers and what combinations will be most effective to eradicate early aggressive tumor populations.
Kinetic and equilibrium study of graphene and copper oxides modified nanocomposites for metal ions adsorption from binary metal aqueous solution
Authors: Ali Alaa H. , Kareem Asmaa Bahjat , Al-Rawi Usama A. , Khalid Ushna , Zhang Shengfu , Zafar Fatima , Papraćanin Edisa , Hatshan Mohammad Rafe , Sher Farooq
Published: November 2023

Presently, the main cause of pollution of natural water resources is heavy metal ions. The removal of metal ions such as nickel (Ni2+) and cadmium (Cd2+) has been given considerable attention due to their health and environmental risks. In this regard, for wastewater treatment containing heavy metal ions, graphene oxide (GO) nanocomposites with metal oxide nanoparticles (NPs) attained significant importance. In this study, graphene oxide stacked with copper oxide nanocomposites (GO/CuO-NCs) were synthesized and characterized by Fourier transform infrared (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray (EDX), and atomic force microscopy (AFM) analytical procedures. The prepared GO/CuO-NCs were applied for the removal of Ni2+ and Cd2+ ions from a binary metal ion system in batch and continuous experiments. The obtained results revealed that GO/CuO-NCs exhibited the highest removal efficiencies of Ni2+ (89.60% ± 2.12%) and Cd2+ (97.10% ± 1.91%) at the optimum values of pH: 8, dose: 0.25 g, contact time: 60 min, and at 50 ppm initial metal ion concentration in a batch study. However, 4 mL/min flow rate, 50 ppm initial concentration, and 2 cm bed height were proved to be the suitable conditions for metal ion adsorption in the column study. The kinetic adsorption data exhibited the best fitting with the pseudo-second-order model. The adsorption isotherm provided the best-fitting data in the Langmuir isotherm model. This study suggested that the GO/CuO nanocomposites have proved to be efficient adsorbents for Ni2+ and Cd2+ ions from a binary metal system.
Describing the scattering of keV protons through graphene
Authors: Bühler Jakob , Roncin Philippe , Brand Christian
Published: November 2023

Implementing two-dimensional materials in technological solutions requires fast, economic, and non-destructive tools to ensure efficient characterization. In this context, scattering of keV protons through free-standing graphene was proposed as an analytical tool. Here, we critically evaluate the predicted effects using classical simulations including a description of the lattice’s thermal motion and the membrane corrugation via statistical averaging. Our study shows that the zero-point motion of the lattice atoms alone leads to considerable broadening of the signal that is not properly described by thermal averaging of the interaction potential. In combination with the non-negligible probability for introducing defects, it limits the prospect of proton scattering at 5 keV as an analytic tool.