bluuebunny/crossref_metadata_2025 huggingface dataset:
Critical Review of Sustainable Peace, Mediative Dialogue and Social Media
Authors: O.A. Adebayo , A.A. Akeem
Published: July 2022

This paper attempts a critical review of the interplay between social media, sustainable peace and mediative dialogue. The paper is grounded in efforts to achieve Goal 16 of the United Nations Sustainable Development Goals: Peace Justice and Strong Institutions. It is the aim of Goal 16 of the United Nations Sustainable Development Goals to promote peaceful and inclusive societies for sustainable development, give justice to all and make possible effective, responsible and all-encompassing institutions at all levels. The paper traced the history of the Sustainable Development Goals to the United Nations (UN) Conference on the Human Environment held in 1972 in Stockholm, Sweden. The Sustainable Development Goals of the United Nations are developed from the Millennium Development Goals (MDGs) and other earlier initiatives of the United Nations. Peace is singled out among these goals, and mediative dialogue is a means to achieving this goal. The advent of the Internet, among other technologies, has significantly changed the ways people communicate globally. Social media in particular is taking a significant role in the ways people, groups and nations resolve conflicts. Through philosophical reflections and qualitative analysis, the paper recommends a framework for deploying mediative dialogue, through social media, for sustainable peace. It is, therefore, concluded that harnessing the strength of the philosophies of the phenomena of social media, sustainable peace and mediative dialogue is a veritable tool for conflict resolution and also for actualizing the aspirations for global peace as inspired by Goal 16 of the Sustainable Development Goals of the United Nations.
Corporate social responsibility and its communication on Twitter: analysis of the discourse and feelings generated in society
Authors:   Escuela Superior de Ingeniería y Tecnología (ESIT). Universidad Internacional de La Rioja (UNIR). Avda. de la Paz, 137. 26006 La Rioja (España) – tatiana.cuervo@unir.net, Cuervo-Carabel Tatiana , Arce-García Sergio ,   Escuela Superior de Ingeniería y Tecnología (ESIT). Universidad Internacional de La Rioja (UNIR). Avda. de la Paz, 137. 26006 La Rioja (España) – sergio.arce@unir.net, Orviz-Martínez Natalia ,   Escuela Superior de Ingeniería y Tecnología (ESIT). Universidad Internacional de La Rioja (UNIR). Avda. de la Paz, 137. 26006 La Rioja (España) – natalia.orviz@unir.net
Published: July 2022

The purpose of this work is to analyze on a global level, without focusing on any specific company or sector, the use that is being made of the social media Twitter to address the communication processes of CSR in companies. To do this, data was captured through programming in R and using an Application Program Interface (API) in Twitter. The data were analyzed using text mining techniques and graphical network analysis with the help of R and Gephi software, respectively. The results show that there are no notable groups or movements in the corporate sphere as generators of CSR content. The importance of the social perspective of CSR in communication processes should be emphasized. Finally, CSR generates positive feelings and emotions such as trust in society. It is concluded that there is no efficient use by companies of Twitter as a CSR communication tool, they are not taking into account the interests of their stakeholders, nor are they generating the dialogue and interaction necessary for communication to be effective. The main limitation is associated with the time period in which the sample was taken, which coincides with a period of strong social concern about the pandemic. It would be interesting for future research to analyze how the discourse changes over time, and to what extent an extraordinary social situation, such as the pandemic, is reflected in CSR communication.
Escape Philosophy
Authors: Christopher Roy
Published: July 2022

The physical body has often been seen as a prison, as something to be escaped by any means necessary: technology, mechanization, drugs and sensory deprivation, alien abduction, Rapture, or even death and extinction. Taking in horror movies from David Cronenberg and UFO encounters, metal bands such as Godflesh, ketamine experiments, AI, and cybernetics, Escape Philosophy is an exploration of the ways that human beings have sought to make this escape, to transcend the limits of the human body, to find a way out.

As the physical world continues to crumble at an ever-accelerating rate, and we are faced with a particularly 21st-century kind of dread and dehumanization in the face of climate collapse and a global pandemic, Escape Philosophy asks what this escape from our bodies might look like, and if it is even possible.
A novel application of dry-electrode EEG Device for knowledge discovery in emotional-behavioral disorder studies
Authors: Ahsan Abdullah  , Meher Abdullah
Published: July 2022

As per World Health Organization (WHO), emotional and behavioral disorders affect 10.7% of global population. Studies have shown emotional-behavioral problems having significant positive correlation with obesity and overweight (P<0.01). It has been established in published body of knowledge that obesity and overweight are negatively correlated with psychological comorbidities, emotional and behavioral disorders, and self-esteem. There is an increasing interest in studying the psychological and cognitive neuroscience aspects of obesity. Lately there has been an increase in the number and availability of consumer grade low-cost EEG (electroencephalographic) devices. The objective of this study is two-fold i.e. exploring the research potential of a consumer grade EEG device (Muse) and analyzing the relationship between EEG electrical activity, depression and obesity. The level of depression was quantified through filling the PHQ-9 (patient health questionnaire) and students BMI (body mass index) noted. The EEG experiment consisted of displaying high and low-calorie visual stimuli along with non-food stimuli; with eyes closed in-between. This process was repeated, first in the hunger state and subsequently after taking a high sugar drink. During both experimental states EEG of the 10 student subjects was continuously recorded. On clustering the EEG recordings, sub clusters were discovered among minimally depressed students, but strong clustering was discovered among mildly and moderately depressed obese/overweight students with lower grades. Thus, mood and food-related information was found to be processed differently among subjects requiring monitoring vs. clinical judgment and consumer grade EEG device was found to have the potential to be used for practical research work.
Educating for Well-being in Law: Positive Professional Identities and Practice edited by Caroline Strevens and Rachael Field
Authors: Seton Mark
Published: July 2022

Educating for Well-Being in Law: Positive Professional Identities and Practice provides both an inspiring and pragmatically grounded set of accounts of what has been done, and could be done to generate positive professional identities and practices in the legal profession.
Ceftriaxone-induced hepatotoxicity in patients with common medical infections in Qatar: A retrospective study
Authors: Barman Manish , Al Hariri Bassem , Rahman Mustafa Abdul , Ambra Naseem , Amjed Israa , Eid Nazzal Alharafsheh Ahmad , Illahi M.N. , Hamuda S. , Gaafar Mohamedali , Sharif Muhammad
Published: July 2022

Introduction: Ceftriaxone, a third-generation cephalosporin, is frequently used for the treatment of various bacterial infections as a broad-spectrum antibiotic for many decades. Although ceftriaxone is a well-tolerated drug in most cases, it can lead to serious liver injury, which can be a real challenge to the treating physician. Given the potentially serious adverse effects that can vary from mild biochemical abnormalities to complete liver failure, we intend to assess the spectrum of liver injury based on biochemical criteria for patients treated with ceftriaxone for common bacterial infections in Qatar.Objectives: This study aimed to explore the incidence of ceftriaxone-induced liver injury at Hazm Mebaireek General Hospital, Qatar, and to evaluate the relationship of the ceftriaxone dose, if any, with liver dysfunction.Methods: This retrospective study included hospitalized adult patients treated with ceftriaxone at our hospital from January 2019 to December 2019 and analyzed demographic and clinical data obtained from electronic medical records. This study determined the incidence of liver injury (primary outcome) in patients treated with ceftriaxone (2 g/day) for ≥ 2 consecutive days by reviewing liver function test results until the day of discharge and at the first outpatient follow-up.

Results: The final data analysis included a total of 634 patients admitted and treated with ceftriaxone from January 2019 to December 2019.In the multivariate analysis with propensity score adjustment, ceftriaxone was independently associated with liver injury, especially when combined with other agents utilizing hepatic metabolism.Conclusions: Ceftriaxone was associated with a significantly higher incidence of liver injury (19.7%) when used along with other medications that are metabolized in the liver, as found in the present study compared with other similar studies (approximately 2.9%–13.9%). Furthermore, the incidence was too high to be ignored in clinical practice.
Sickle cell disease: A global health concern; pathophysiology, epidemiology and advances in point of care diagnostics
Authors: Sweta Gupta  , Poornima Gautam  , Lokeswara Balakrishna  , Killamsetti Venkatramana  , Rishabh Paroha  , Parikipandla Sridevi
Published: July 2022

Sickle cell disease (SCD) is the most critical “hemoglobinopathy” worldwide in terms of frequency, and social impact. Recently, it is recognized as global health concern by World Health Organization (WHO). SCD affects approximately 5% of the world population with a various estimate in different continents. Deaths from SCD are evitable by cost effective diagnosis and efficient health interventions for management. Our comprehensive review focuses mainly on the prevalence of SCD, its associated clinical features including crisis, pulmonary pathobiology, muscular, neurological, hepatobiliary and ophthalmological complications along with frequent sepsis and priapism. Further, the present scenario of SCD diagnosis and confirmation requires sophisticated equipment, reagents and adequately trained laboratory persons, also there is unmet requirement for advance methods, to diagnose and monitor SCD that are both inexpensive and accessible. As new diagnostic methods are delayed in clinical trials and more are in pipeline, the purpose of this review is also provides an overview on emerging point of care (POC) techniques offering hope for detection and management of this unfortunate disease.
Impact of job stress and job satisfaction on online teaching among CBSE school teachers during COVID-19 pandemic outbreak
Authors: Raman Manju Shree , Mudduluru Ramana Raju , Suganthi D. , Anjani P. K. , Kavitha Anbu , Kannappan Sindhura
Published: July 2022

Education is the process through which a mature human mind evolves from a child's mind. Education is a means for disseminating information about both known and unfamiliar topics. It will enable the human brain to comprehend known and unfamiliar concepts in greater depth. As days pass, so do educational methods, which shift according to the needs of the hour. As a result of the COVID-19 crisis, all educational institutions have moved to virtual courses and an online education system that is separate from the actual surroundings. The Indian education system is not new to technological growth, but being exposed to it frequently and adapting to the current condition could make educators vulnerable. Before any changes take place, transition space is required to adapt and become accustomed to the new circumstances. However, the pandemic condition provided enough time for the shift to adapt to the technological civilization. This has a greater effect on online instructors. This study examines how the severity of the influence on education professionals who teach online impacts their psychological well-being, as well as solutions for dealing with the technological culture and psychological well-being.
Reading readiness, brain intelligence, interest and motivation as predictors to the English reading level among elementary learners
Authors: Martinez Judith S.
Published: July 2022

Several studies show that reading readiness is one of the factors that have to be considered in developing the reading ability of the students.  It is a process of preparing a child for reading, encouraging the child to read and engaging that child in reading. In other words, it is a state of development, which prepares the child mentally, physically, and social-emotionally for reading experiences.  This study specifically sought to determine the reading readiness, brain intelligence, interest and motivation of the elementary learners and find out if those variables significantly predict the reading levels of the two groups of students, those under inclusion and exclusion of reading speed. 168 fourth grader learners in the Division of Zamboanga City, Philippines had voluntarily participated in this research. The researcher utilized the  Philippine Informal Reading Inventory (Phil-IRI) to answer  the research question. Research protocols were also observed and followed in this study, Clearance for Ethics Implementation was sought, before the actual data gathering procedure. Data revealed that reading readiness, brain intelligence, interest and motivation of the pupils do not significantly contribute to the Reading Level of Pupils in the Inclusion Group.
A review article on
Authors: Ranjan Shashi , Himani Devi , Mukopadayay Sayantan
Published: July 2022

These are well-known health benefits of papaya (Carica papaya Linn.). Ayurveda, for example, recognises papaya's therapeutic value. Herbalists have used it to cure bilious fever, gonorrhoea, eczema, rheumatism and headaches. It took four decades of amazing research to identify a critical nutraceutical compound. It is antibacterial, antipyretic, insecticidal, antimicrobial, and antimolluscan. Leaves have been studied using phytoextraction of heavy metals and phytoremediation of particle pollution. Long-term research on phytoconstituents and leaf composition. Malaria, dengue fever, inflammation, and skin infections are all treated by Carica papaya. C. papaya flowers were first tested for antioxidant and antibacterial properties using TLC and UV spectroscopy. Our tests included TLC and UV-visible spectroscopy. The methanol extract had the most alkaloids, flavonoids, saponins, and tannins. N-hexane had steroids and flavonoids while chloroform had saponins and tannins. In it, there were flavonoids and phenolic compounds.
Taste masking of oral pregabalin liquid preparation by using ion exchange resins
Authors: Bidkar Shital J. , Rao M. E. Bhanoji , Dama Ganesh Y. , Bidkar Jayant S.
Published: July 2022

The purpose of this study was to use cation exchange resins to mask Pregabalin's unpleasant taste. Dowex-50, a crosslinked polystyrene backbone, was employed. DRCs were synthesised in batches with drug-to-resin ratios of 1:1, 1:2, and 1:3. The optimal drug-to-resin ratio as well as the time required for maximum complexation were discovered. In this work, an attempt was made to develop a taste-masked Pregabalin solution using a simple, rapid, and cost-effective flavour masking approach, such as complexation among ion exchange resin, that could be acceptable to industries. To mask the flavour, researchers used a combination of ion-exchange resins such as doshion P 542, Tulsion 344, Indion 234, Indion 204, and Kyron T 114, as well as formulation into a solution. The generated suspensions were tested for taste, drug content, particle size, viscosity, sedimentation volume, drug release, and accelerated stability. Kyron T 114 has been shown to effectively disguise the drug among the various resins. The newly developed formulation also has the benefit of simplifying the manufacturing process and being cost-effective. According to drug release studies, the entire medicament was released within 20 minutes.
Intralesional penicillamine in the treatment of keloids and hypertrophic scars
Authors: Al-Rawi Jamal R. , Ahmed Mohammed J. E. , Taher Ali K.
Published: July 2022

Background: Many therapeutic options have been tried in the treatment of keloid and hypertrophic scars, but no one is superior to others. Penicillamine has been used systemically but not tested as intralesional. Objective: The aim of this study was to evaluate the effectiveness & safety of intralesional penicillamine for treatment of keloids and hypertrophic scars. Patients and Method:  this is open labeled therapeutic trial study encountered in Department of Dermatology and Venereology in Al-Yarmouk teaching Hospital, Baghdad-Iraq. Collection of data was carried out during the period between May 2010 – February 2011. This study included 28 patients with keloids and hypertrophic scars.  Penicillamine was prepared as a solution for intralesional injection by dissolving (250mg) of Penicillamine (Artamin)® by SANDOZ in (10ml) distilled water in sterilized container to obtained (2.5%) concentration of Penicillamine and autoclaved at 121C0 for 20 min before use. Penicillamine was administered with 27-gauge needle syringe without anesthesia. Seventy percent ethanol was used as an antiseptic agent before injection. Four sessions of intralesional injection were given at intervals of 15 days each.
Combination of one or more characteristics framework for optimizing energy in cloud computing
Authors: Muthusankar D , Dhanaprakash V , Kavin K
Published: July 2022

The extending advancement in the interest for dispersed figuring organizations, due to the verifiably progressed change and the high adaptability of the cloud, requires more undertakings to further develop the electrical energy adequacy of cloud server ranches. In this paper, an energy-capable creamer (EEH) framework for working on the efficiency of consuming electrical energy in server ranches is proposed and evaluated. The proposed structure relies upon both the sales' reserving and laborers' mix approaches as opposed to depending upon only one procedure as in existing related works. The EEH structure sorts the customers' requesting (tasks) according to their time and power needs before playing out the booking. It has a booking estimation that thinks about power use when taking its arranging decisions. It in like manner has an association estimation that chooses the underloaded laborers to be refreshed or rested, the over-trouble laborers, the virtual machines to be moved and the specialists that will get moved virtual machines. Moreover, the EEH structure joins a development computation for moving migrated virtual machines to new laborers.
Virtual Queuing Ration Distribution in Cloud Environment
Authors: Seenivasan D , Harini J K , Nandhini P
Published: July 2022

Ration shops are one of the main food product supply centers of Government. has an insignificant amount of goods, theft of material, large waiting time in the ration store and they keep all records in big paper file. This project is execute to overcome the obstacle that exist in the current distribution system. Ration cards are replaced with the smart card in which all the required information (name, contact number, aadhar number) are saved. Once the materials are delivered to the shops by government, through the websites or SMS all customer are asked to collect the ration.The customer checks the availability of products through the website to choose products as per their card type. Then customer will receive OTP to confirm order. Then the controller checks the customer code and details which is stored in database. Once the authentication of the customer is done, then the collecting time will send through SMS. The exact amount of food grains is extracted immediately and as soon as the ration is dispensed email notification is sent to the customer’s mobile.
How effective were the COVID-19 relief measures? A comparative analysis of the seven largest economies of the world
Authors: Kishan Kishan
Published: July 2022

This paper examines the effect of policy measures adopted by governments worldwide since the onset of the COVID-19-led pandemic on health and social sectors and the global economy. Taking the case of the United States, India, the Republic of Korea, China, Brazil, Saudi Arabia, and Germany, it comparatively studies the effect of pandemic and related policy measures: on the unemployment rate, GDP growth, per capita income, inequality (measured using the Gini coefficient), accumulated real income, interest rates of Central Bank of the respective countries, Relief packages as per the percentage of GDP, and Cash transfer by number of people covered of the said countries. Developing countries preferred to use direct cash transfers to the beneficiary account rather than providing food baskets as most developed countries provided to their population of the lower economic strata. Except for China, there is a contraction in the GDP of all the countries witnessed in 2020 and is set to rebound in 2021 and 2022. It is witnessed that the impact of the pandemic is uneven in different sectors, regions, and socio-economic groups; in some cases, the repercussions of these measures are likely to continue.
Image processing and machine learning approaches for the automatic diagnosis of endometrial cancer
Authors: Aparna P R , Libish T M
Published: July 2022

In many medical imaging based diagnosis, Deep Learning (DL) algorithms play an essential role. A DL algorithm can be used to identify abnormal and normal cells in the uterus's endometrium in order to discover Endometrial Cancer (EC) cells. EC is difficult to diagnose since it develops without causing any symptoms. DL algorithm can distinguish between normal, abnormal, and malignant cells, producing more accurate findings than screening by hand procedures such as liquid cytology and Pap smear test. For the accurate and easier detection of EC cells, DL employs multiple architectures. The findings of an analysis and survey of the many forms of DL architecture, as well as their accuracy and performance, are addressed in this work. Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) are the most modalities of advanced imaging used for the non-invasive diagnosis of EC. EC is considered as the fourth most prevalent malignancy in women and one of the common most gynaecological cancers. Diagnostic imaging in clinical evaluation with has not been proven yet to be precise enough to substitute surgical staging in determining the spread of cancer. It may allow for improved surgical process optimization and a more customised therapeutic plan.
Enrichment and optimization of drinking water by hydro distilled extract of Ocimum sanctum L.
Authors: Naidu Ravi Teja , Lakshmi M V V Chandana , Mishra Vijay Kumar , Grandhi Rohith
Published: July 2022

Ocimum sanctum L. is commonly named Tulsi in India, is an herb belonging to the Lamiaceae family. It has enormous medicinally valuable essential oils such as eugenol, oleanolic acid, carvacrol, linalool secondary metabolites. It is used to treat various diseases in Ayurveda and also in the processes of several pharmacological properties such as antioxidant, antifungal, antibacterial, antidiabetic, antifertility, hepatoprotective, analgesic, cardioprotective etc. It has natural source of minerals like Iron, Calcium and Sodium. Present work enhances the composition of regular drinking water with addition of extract by hydro distillation and develops herbal water. It was found that the properties of herbal water was unchanged for a month.
Customer satisfaction in public and private sector banks
Authors: Bhadauriya Ankur
Published: July 2022

Indians banking sector is likely to face tough competition in the coming few years because many of the recent policy started by the Indian government start to take effect and new entrants also show to make their presence felt. It is possible to be a case of survival of the best, or in other words, the most successful. A bank’s ability to make profits in an increasingly competitive market will be based on the number, and quality of its investors, thus consumer satisfaction must continue to be a key area for all banks in the future. Past studies have proved that service quality in an example of consumer satisfaction This paper user the SERVQUAL model to show which of the five service quality dimensions of tangibility, reliability, responsiveness, assurance and empathy have an effect on consumer satisfaction in public sector and private banks.
Medial plantar artery flap
Authors: Kumar Vijay N. , Kakola Mohan G. , Raj Pradeep S. , Chandrashekar M. S.
Published: July 2022

Background: The unique ability of the thick glabrous skin of the plantar heel to withstand body weight while also providing protective sensory feedback makes soft-tissue coverage of the plantar heel a particularly challenging aspect of foot reconstruction. In this study, we present the outcomes and complications associated with medial plantar artery perforator (MPAP) flap reconstruction of plantar heel. Methods: The study was a retrospective study conducted over four years, and included 22 patients with soft-tissue injury to the plantar heel. All patients underwent MPAP flap for coverage of the defect. We studied the  mode of injury, defect size, flap size, duration of the procedure, complications associated with the flap and donor site, time to full weight bearing and return of protective sensation and 2-point discrimination in comparison with opposite heel. Results: We studied 22 cases with soft-tissue defects of the heel that included post-traumatic defects (7), non-healing diabetic ulcers (6), trophic ulcers (4) and post- tumor excision defects (melanoma-3, squamous cell carcinoma-2). Mean flap dimension was 24 sq.cm. 18 flaps had complete survival, while 2 flaps had necrosis of the distal edge and 2 flaps underwent complete necrosis.
Evaluate the biomarkers of bone turnover in patients with in sickle cell anemia in Basra province
Authors: Oudah Lamyaa K. , Kadhim Hanaa S. , Thuwaini Mahdi M.
Published: July 2022

Background: Sickle cell anemia (SCD) is one of many haemoglobinopathic disorders which is probably the most common known hereditary blood disorder. In this disease, the homozygous state in which the sickle gene is inherited from the father and the mother, and patients with sickle cell disorders often suffer from chronic hemolytic anemia, which causes bone marrow hyperplasia too.  The present study was designed to evaluate the biomarkers which related with the bone turnover in sickle cell anemia  patients. Patients with SCA (n=120) 60 males and 60 females were on follow up in the Basra center for Hereditary Blood Disease, who were included in this study and age and sex matched healthy persons (n=60) as controls. biomarkers had important role in many biological processes. Aims: of this study to measure serum levels of different biomarkers such as; BCTx, BSAP, CRP, DPD, IGF-1, OT, TRACP-5b, FER, IGFBPT, Intact (iPTH), Ostase, PINP and serum Ca+. Using Kruskal-Wallis test as statistical test, markers in sickle cell anemia and control groups.The results: showed no significant difference of both male and female patients (HbSS, HbSC and sickle- β-Thalassemia) in compared to control group.
Forecasting political parties and candidates for Indonesia’s presidential election in 2024 using twitter
Authors: Masud Riduan , Syamsurrijal Muhammad , Baharuddin Tawakkal , Azizurrohman Muhammad
Published: July 2022

The purpose of this study is to forecast the political parties and candidates running for president of Indonesia in 2024. Nvivo 12 software is used in this study's quantitative methodology for descriptive content analysis. Twitter users are the study's research subjects. The information was collected via Twitter Search, which targeted the term "Pilpres 2024." According to this analysis, Anies Baswedan, Prabowo, and Ganjar Pranowo will be the winning candidates. Political parties' geographic distribution reveals that the 2024 presidential election would see political tensions between parties with nationalist and religious ideologies.
Energy sources, control, global warming, what must be done and a possible role for ‘sundownloaders’
Authors: Tom Robin Caine Boyde
Published: July 2022

Global warming is a genuine threat to human survival, though causes and therefore also solutions are more subtle, complex and difficult than usually supposed. Burning fossil fuels is a contributor; also 8 billion humans breathe out about 2 billion tons per year of carbon dioxide, just to stay alive; yet total human energy usage is a tiny fraction of solar radiation energy received by our planet. Standard reactions so far are inadequate, costly, dangerous and mis-directed. An essential internationally-agreed programme to deal with the crisis must include reduction of the human population, better use of solar radiation, and a colossal research effort to find better ways of trapping atmospheric carbon dioxide and converting it into hydrocarbons - so as to achieve at least carbon-neutrality and yet allow use of much the most efficient means we yet know to both store energy and have it ready to hand. The alternative to such a programme is world-wide economic, political and biological disaster, including possible extinction of Homo sapiens. Sundownloaders may make a useful contribution in one area - making better use of solar radiation. It is already clear that food production using artificial light cannot provide enough at low enough cost to feed the present human population. The present global warming process, its causes and consequences, are the subject of millions of words per day in paper and internet media communications, but with no sign of deep understanding: this paper is intended to clarify and balance the problems from a serious practical viewpoint, offering serious suggestions about what really should be done by individuals, organisations, businesses, politicians and governments around the world. Global warming is real, its causation not as simple as some make out. Humans need energy from food, merely to survive, and the more humans exist the greater is that requirement. The quantity and cost of energy requirements for social and business functions are often obscured or misrepresented: here we shall challenge what are often unwarranted assumptions and proposals, making new ones. Yes, there is room for disagreement: yes, any statement whatever can be questioned and the truth can only be established if that is done and the argument judged without prejudice; Science, not self-advertisement, not propaganda.
Unlocking Crucial Cortical Connections in Human Neural Dynamics for Health and Disorder
Authors: Currin Christopher Brian
Published: July 2022

Epilepsy is a devastating disease that affects millions of people worldwide. Modern gene typing allows us to identify the genetic background of this burdensome disease but understanding the influence of genetic differences on seizure dynamics in human cortical networks remains difficult, not least because of the ethical complexities of clinical neuroscience.

Recently, it has become possible to grow cultures of human cortical networks ex vivo and obtain the activity at single-cell resolution over extended periods of time. Here, I propose to develop the computational and theoretical tools to analyse the emerging dynamics in human cell cultures and compare them, for the first time, to the long-standing theoretical models of excitatory and inhibitory neural networks.

This collaborative work will help to reveal the differences between natural and disease dynamics and contribute to effective life-long clinical treatments.
ACUTE TOXICITY TEST OF RAMBUTAN HONEY ADHESIVE CREAM AGAINST SWISS WEBSTER MICE (UJI TOKSISITAS AKUT KRIM PEREKAT MADU RAMBUTAN TERHADAP MENCIT SWISS WEBSTER)
Authors: Reni Yuslianti Euis , Meliawaty Florence , B. Sutjiatmo Afifah , Pradita Ariana
Published: July 2022

Denture adhesive is indicated for conditions of poor retention and stabilization. Commercially available denture adhesives have side effects, thus requiring a safer alternative adhesive, one of which is rambutan honey adhesive cream. Rambutan honey is safe and does not cause toxic effects on test animals. This study aimed to observe the impact of acute toxicity of the orally administered rambutan honey adhesive cream on mice. The research method is an experimental laboratory method and was carried out using 24 male and female Swiss Webster mice. The subject was divided into four groups, one being the negative control group. Rambutan honey adhesive cream was given in three dose groups, namely 1250, 2500, and 5000mg/kg BW. Observations made were death, body weight, behavioural changes, and relative organ weight in mice for fourteen days. The analysis test was carried out using the one-way ANOVA (p < 0.05). The results showed that rambutan honey adhesive cream did not cause death and toxicity symptoms in mice. There was no significant increase in body weight in male and female mice in the group. In the control group, the macroscopic necropsy analysis did not show any change in color and organ index of the heart, lung, liver, spleen, and kidney. This study concludes that the oral administration of rambutan honey adhesive cream on male and female Swiss webster mice is safe and is classified as practically non-toxic.
COATED TONGUE TREATMENT USING TONGUE SCRAPER ALL OVER THE SURFACE OF TONGUE DORSUM
Authors: Puti R Sabirin Indah , Zhafarina Mega
Published: July 2022

A coated tongue is characterized by a white, yellowish-brown, or blackish-coloured coating on the tongue's surface. Coated tongues are formed from debris consisting of bacteria on the dorsal surface of the tongue, a large number of desquamated epithelial cells derived from the oral mucosa, leukocytes from periodontal pockets, and blood metabolites, and a variety of different nutrients. Score according to Gomez's justification to see the colour change in this case score one and Miyazaki classification to see the distribution of the spread of white plaque in the case of score 3. The treatment plan in this case provides medication in the form of chlorhexidine gluconate mouthwash 0.2% and an emphasis on maintaining oral hygiene and using tongue scraper aids. Patients were asked to do one week and five weeks of control to see the development of lesions in the form of white plaque.
MTHFR C677T rs1801133 GENE POLYMORPHISM AS A RISK FACTOR FOR NONSYNDROMIC CLEFT PALATE ONLY AMONG DEUTERO MALAY SUB RACE IN INDONESIA
Authors: L. Nasroen Saskia , Tammama Tichvy , AN Putri Gracia
Published: July 2022

Nonsyndromic cleft palate only (NS CPO) is a congenital malformation that arises from palatal fusion failure process at the seventh week of palatogenesis with a prevalence of 1:1000 live birth worldwide. The MTHFR C677T rs1801133 gene polymorphism is one candidate gene that can be associated with NS CPO. This study aims to determine the risk factor for NS CPO through MTHFR C677T rs1801133 analysis among the Deutero Malay subrace of the Indonesian population. This study was a case-control design, using samples from venous blood of 50 NS CPO subjects and 51 healthy control subjects. After DNA was extracted, followed by PCR, the PCR-RFLPs method was performed using the HinfI restriction enzyme. The Chi-Square test was used with the Kolmogorov Smirnov and Exact Fisher alternatives. The results showed that CT genotype (OR=2,960, p<0.05) of MTHFR C677T rs1801133 gene polymorphism can increase the risk of NS CPO. MTHFR C677T rs1801133 gene polymorphism is a risk factor associated with NS CPO among the Deutero Malay subrace in the Indonesian population.
Agama dalam Perspektif Emile Durkheim
Authors: Putri Indah Suzana Aulia
Published: July 2022

Dalam bukunya yang berjudul The Elementary Forms of Religious Life (1912), Emile Durkheim menaruh perhatian untuk menemukan hal-hal fundamental atau elemen dasar yang membentuk agama melalui kehidupan religius masyarakat primitif. Penelitiannya terhadap masyarakat primitif memperlihatkan praktek agama paling dasariah/elementer yang pernah ada. Menurut Durkheim, kita tidak dapat memahami agama paling modern tanpa menelusuri sejarah dari berbagai peranan yang telah membentuknya. Sejarah memungkinkan kita untuk mengurai suatu institusi sampai kepada komponen-komponen pembentuknya. Jika kita ingin menjelaskan sesuatu yang berkaitan dengan manusia, kita harus memulai dengan kembali kepada bentuk paling sederhana dan paling tua dari hal tersebut. Oleh karena itu, bila kita ingin memahami agama baik agama modern ataupun primitif, agama universal ataupun lokal, kita harus menelusuri kembali kepada bentuk agama yang paling sederhana dan tua, yang dalam hal ini adalah Totemisme.
Akar
Authors: Mohamad Goenawan
Published: July 2022

Pada 18 Juni 2022, di Galeri “Roh”, Jakarta dibuka pameran senirupa  Syaiful Aulia Garibaldi, seniman yang bekerja dari Bandung dengan puluhan karya yang sudah dipamerkan di pelbagai galeri di dunia. Goenawan Mohamad diminta membuka dialog dengan Garibaldi. Artikel yang ditulis pada jurnal ini merupakan bagian utama dari percakapan itu. Menurut Goenawan, karya Syaiful Aulia Garibaldi dapat dilihat sebagai kontras terhadap estetika Mondrian. Kehendak Syaiful untuk mengaitkan seni rupanya dengan sains bisa jadi sesuatu yang problematis. Namun menurut Syaiful, kerja Seni dan Sains justru saling menguatkan. Dalam pengalaman berkarya, jawaban atas pertanyaan untuk apa dan apa gunanya berkarya, justru didapatkan dari lingkungan Sains.
Dekonstruksi Imortalitas dalam kerangka Kritik terhadap Modernitas dan Pascamodernitas: Telaah Zygmunt Bauman
Authors: Putranto Hendar
Published: July 2022

Rasa takut akan kematian dan damba akan kekekalan sudah lama dibahas agama dan filsafat. Sayangnya, masih teramat sedikit ilmu sosial lintas-disiplin dan multi perspektif yang mengaji isu mortalitas dan imortalitas sekaligus dalam bentuk buku tunggal (monograf). Merefleksikan pandangan Zygmunt Bauman dalam Mortality, Immortality, and Other Life Strategies (1992), penulis menawarkan rekonstruksi pemikiran Bauman tentang konsep modernitas dalam hubungannya dengan isu mortalitas dan konsep pascamodernitas dalam hubungannya dengan isu imortalitas. Sebagaimana modernitas mendekonstruksi isu besar mortalitas menjadi sejumlah problem yang bisa ditangani, demikian juga pascamodernitas mendekonstruksi isu imortalitas menjadi enam model berbasis problem, seperti problem identitas yang cair sebagai proyek konstitusi-diri (identitas pengembara), ketenaran dalam fesyen dan selebriti, ide repetisi dan representasi, permainan dan tontonan, rantai kenikmatan sesaat yang ultim, sebagai strategi stratifikasi sosial, dan sebagai penegasan identitas sekaligus otoritas dalam komunitas. Strategi dekonstruksi kekekalan mengemansipasi subjek pelaku, baik dalam dimensi individualitas maupun kolektivitasnya, dari keterbelengguan terhadap ruang-waktu (sejarah, wacana, ideologi, dan lain-lain), memampukan orang untuk meraih sesuatu yang pada prinsipnya mustahil untuk dijangkau di sini dan sekarang, tapi sekaligus menyimpan potensi ketidakadilan (misalnya lewat strategi stratifikasi dan eksklusi, juga privilese akses elit terhadap kekekalan), menonjolkan primasi entitas yang ontis di atas yang etis, serta melahirkan gugus korban baru. Dalam konteks yang lebih kekinian, cara-cara baru untuk mendekonstruksi imortalitas telah mengalami pergeseran dari dunia hiburan ke ranah teknologi, tapi ide imortalitas tetap dipreteli aura kesuciannya dan secara terus-menerus dibuat menjadi profan dan dikomodifikasi. Imortalitas dijadikan satu dari sejumlah objek hasrat yang tersedia di pasar dan dapat dibeli dengan uang. Betapapun hasrat menjadi kekal terus didamba dan diupayakan untuk terwujud di sini dan sekarang, entah dengan bantuan serum anti-aging, dengan mengunggah jejak-jejak identitas dan kesadaran dalam mesin pintar yang digerakkan kecerdasan buatan terpersonalisasi, record and digitize, ataupun dengan teknologi cryonics, tantangan dan tentangan terus datang silih berganti.
TESIS ESTETIK GM Perihal Rupa, Kata, Obyek, dan yang Grotesk Goenawan Mohamad
Authors: Prasetyo Arif Bagus
Published: July 2022

Pada 18 Juni 2022, di Galeri “Roh”, Jakarta dibuka pameran senirupa  Syaiful Aulia Garibaldi, seniman yang bekerja dari Bandung dengan puluhan karya yang sudah dipamerkan di pelbagai galeri di dunia. Goenawan Mohamad diminta membuka dialog dengan Garibaldi. Artikel yang ditulis pada jurnal ini merupakan bagian utama dari percakapan itu. Menurut Goenawan, karya Syaiful Aulia Garibaldi dapat dilihat sebagai kontras terhadap estetika Mondrian. Kehendak Syaiful untuk mengaitkan seni rupanya dengan sains bisa jadi sesuatu yang problematis. Namun menurut Syaiful, kerja Seni dan Sains justru saling menguatkan. Dalam pengalaman berkarya, jawaban atas pertanyaan untuk apa dan apa gunanya berkarya, justru didapatkan dari lingkungan Sains.
Diplomasi Indonesia di Laut China Selatan
Authors: Sungkar Syakieb
Published: July 2022

Konflik di China Selatan dimulai ketika di tahun 1994 Tiongkok mengukir 9 garis putus-putus dalam peta laut China Selatan. Namun akar permasalahan yang sesungguhnya sudah dimulai sejak tahun 1930 karena minimnya pengetahuan pemerintah Tiongkok dalam Geografi. Indonesia yang semula berada dalam garis depan melindungi negara-negara ASEAN, kemudian berbalik arah melindungi dirinya sendiri dari klaim Tiongkok atas Natuna. Sementara Jokowi lebih menginginkan adanya diplomasi yang realistis sambil mengharapkan masuknya investasi dari negara tirai bambu itu.
C68: Tumeurs phyllodes et sarcomes du sein : A propos de deux cas à la matéernité du Centre Hospitalier Régional de Thiès
Authors: Guèye L , Thiam M , Bentefouet L , Gaye M , Mahamat S , Cissé ML
Published: July 2022

INTRODUCTION : Les tumeurs phyllodes et les sarcomes du sein s’intègrent dans le cadre nosologique des tumeurs non épithéliales du sein. Les tumeurs phyllodes se distinguent en tumeurs bénignes, à malignité intermédiaire ou maligne (sarcome phyllode). Les sarcomes primitifs du sein représentent environ 1% des tumeurs du sein et moins de 5% de l’ensemble des sarcomes. Le diagnostic de ces tumeurs est souvent difficile et le pronostic repose essentiellement sur la qualité des marges d’exérèse et du grade. L’objectif de notre étude était d’évaluer les difficultés diagnostiques des tumeurs phyllodes et du sarcome du sein à travers deux cas sous traitement à la Maternité du Centre Hospitalier Régional de Thiès. OBSERVATIONS : Cas 1 : Il s’agissait d’une patiente âgée de 18 ans, reçue en consultation pour une masse mammaire droite évoluant depuis deux ans. L’examen retrouvait une masse dure prenant tout le sein droit dont le grand axe mesure 10 cm, pas adénopathie axillaire. Le sein gauche était normal. L’échographie mettait en évidence au niveau du sein droit, des masses tissulaires hétérogènes faiblement vascularisées dont les plus grosses mesurent 18,2 mm, 13,1 mm et 14,1 mm associée à une multitude ganglions mammaires homolatéraux évoquant plus un lymphome qu’un hémangiome. La biopsie concluait à une tumeur vasculaire de type hémangiome ou lymphangiome, pas de signes de malignité. Une deuxième biopsie évoquait une tumeur vasculaire de malignité modérée grade 2 de type hémangioendothéliome. Le scanner thoracique était en faveur de localisations secondaires pulmonaires. Une mastectomie de propreté fut réalisée et l’examen anatomopathologique de la pièce opératoire évoquait un hémangiome capillaire sans signe de malignité. La patiente était revue au bout d’un mois avec une localisation secondaire pré-sternale. Elle bénéficie actuellement d’une chimiothérapie adjuvante. Cas 2 : Il s’agissait d’une patiente de 14 ans, reçue en consultation pour une masse mammaire droite d’évolution rapide. L’examen retrouvait une volumineuse masse mammaire droite de 22x20 cm avec une peau en regard tendue. L’échographie et la biopsie étaient en faveur d’une tumeur phyllode. Devant le caractère évolutif très rapide et la fistulisation de la tumeur, une mastectomie était réalisée et la pièce envoyée en anatomopathologie. CONCLUSION : Le diagnostic des tumeurs phyllodes est difficile et tout retard de prise en charge rend plus sombre le pronostic. Les angiosarcomes entrainent des localisations pulmonaires fréquentes, et une diffusion hématogène au niveau osseux, cérébral, cutané. La chirurgie reste le traitement de référence. Compte tenu du pronostic très sombre de ces angiosarcomes et de leur potentiel métastatique précoce, il parait logique de discuter systématiquement une chimiothérapie adjuvante.
C72: Gestion des sarcomes phyllodes : Une étude rétrospective de 12 cas
Authors: Diallo EMM , Ndiaye JC , Dia AEH , Huchard S , Kane Ba NF , Lionel E , Rachidou H , Frederique M , Ka K , Dieng MM , Gaye PM
Published: July 2022

INTRODUCTION : Les sarcomes phyllodes sont rares. Il n'y a pas assez de données pour codifier la prise en charge. L'objectif était d'étudier les aspects cliniques et thérapeutiques et le devenir des patients après un suivi d'au moins de quatre ans et de contribuer ainsi au corpus limité de connaissances sur ces tumeurs. MATERIELS ET METHODES : Une analyse rétrospective des dossiers de 2013 à 2017 a été réalisée et les patients ont été suivis jusqu'en 2021 à l'Hôpital Hassan II. Les aspects épidémiologiques, cliniques et thérapeutiques ont été étudiés. La survie a été calculée par la méthode de Kaplan-Meier. RESULTATS : Nous avons recueilli 12 dossiers de patients traités pour un sarcome phyllode de 2013 à 2017. L'âge médian était de 43 ans. La circonstance de découverte était marquée par la présence d'un nodule chez tous les patients. L'examen d'écho-mammographie couplée a classé les nodules, ACR 4 chez sept patients et ACR 3 chez trois et ACR 5 chez deux patients. L'examen histologique a révélé un sarcome phyllode chez 11 patients et une tumeur phyllode borderline chez un patient. Tous les patients ont subi une chirurgie radicale avec des marges positives chez deux patients, soit 16,66%. Un patient a subi une reprise chirurgicale. L'examen histologique des pièces chirurgicales a montré un sarcome phyllode sur toutes les pièces. Tous les patients ont reçu une radiothérapie adjuvante avec des doses de 50 Gy en 25 fractions de deux Gy et un boost de 10 Gy a été effectué chez un patient. L'étalement médian de la radiothérapie était de 37 jours. Des toxicités cutanées de grade 1 et 2 ont été notées chez cinq et trois patients respectivement. Le délai médian entre la chirurgie et la radiothérapie était de 2,95 mois. Trois patients ont rechuté après 13,6 mois de suivi. La survie sans récidive à un et trois ans était de 83% et 75% respectivement. La survie globale à trois et cinq ans était de 83% et 75% respectivement. CONCLUSION : Il s'agit d'une entité rare qui nécessite des essais randomisés pour codifier sa prise en charge. Il semblerait que l'approche multidisciplinaire, associant chirurgie ± radiothérapie, soit une bonne option.