bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of Oncoproteins E6 and E7 of high-risk Human Papilloma Virus on Breast Cancer
Authors: Lopes Ana Karina Brizeno Ferreira , Padilha Marina Viana , Maux Julliano Matheus de Lima , da Silva Sandra Maria Souza da Silva , Azevedo Elayne Interaminense Cavalcanti de Brito , Nascimento Eloiza Maria do , Azevedo Júlia Barroso Cirne de , Melo Cristiane Moutinho Lagos de , Neto Jacinto Costa Silva
Published: January 2023

Breast cancer is the most frequent neoplasm in the world, and its causes are multifactorial. Some risk factors are already well established, and others are still being studied, such as infections with certain agents, like the human papillomavirus (HPV). This study aimed to carry out a literature review about the association between breast cancer and HPV, aiming to analyze the role of their E6 and E7 oncoproteins, using PUBMED and LILACS databases for the research. Of the 41 articles included in the study, 30 endorse the association of HPV with breast cancer, of these, only eight with statistically significant values. This study found HPV 16 as the genotype with the highest detection rate and ductal carcinoma as the histological pattern with the highest frequency. Formalin-fixed and paraffin-embedded tissue (FFPE) was the most studied type of sample storage and preservation, and polymerase chain reaction (PCR) was the most used detection method. The virus genetic material was found integrated into the host cell genome in most of the samples. Given the findings, it was concluded that HPV can have a great influence on breast carcinogenesis, however, studies involving the carcinogenic pathways of HPV, and morphological and molecular patterns should be carried out involving a larger sample.
Increasing the Growth and Product of Red Spinach and Study of it’s Benefits as a Source of Nutrition Fe for Body Health
Authors: Gunawan Bambang , Purwanti Sri , Nurlina Nurlina , Huda Nurul
Published: January 2023

The purpose of this research to determine the effect of the combination of manure and EM-4 on the growth and yield of red spinach and to study its benefits as a source of Fe nutrients for health. This study was an experimental study using a randomized block design (RBD) in the combined treatment of manure with EM-4. The manure (P) was at three levels, namely: P1 = 5 tons/ha of manure dose; P2 = Dose of manure 10 tons / hectare; P3 = Dose of manure 15 tons / hectare; while giving the concentration of EM-4 (K) with three levels, namely: K1 = 5 ml EM-4 / liter of water; K2 = 10 ml EM-4 / liter of water; K3 = 15 ml EM-4 / liter of water. There was a significant effect of the combination treatment of manure with EM-4 studied, namely on the variables of plant height, number of leaves and fresh weight. Consuming fresh red spinach regularly according to the Nutrition Adequacy Rate is very beneficial for body health because the content of iron, calcium, copper, thiamine, fiber, zinc and water including high and quite high.
Clustering algorithms with prediction the optimal number of clusters
Authors: Agárdi Anita , Kovács László
Published: January 2023

The clustering is a widely used technique for grouping of objects. The objects, which are similar to each other should be in the same cluster. One disadvantage of general clustering algorithms is that the user must specify the number of clusters in advance, as input parameter. This is a major drawback since it is possible that the user cannot specify the number of clusters correctly, and the algorithm thus creates a clustering that puts very different elements into the same cluster. The aim of this paper is to present our representation and evaluation technique to determine the optimal cluster count automatically. With this technique, the algorithms itself determine the number of clusters. In this paper first, the classical clustering algorithms are introduced, then the construction and improvement algorithms and then our representation and evaluation method are presented. Then the performance of the algorithms with test results are compared.
Assessment of micro-indentation method in the characterization of DP600 behavior using a proposed martensite distribution parameter in FEM simulation approach
Authors: Cuervo Basurto Anyerson , Narvaez Tovar C. A. , Rodríguez Baracaldo R.
Published: January 2023

This work proposes a simulation approach to characterize the behavior of DP600 steel subjected to micro indentation tests. Axisymmetric and three-dimensional artificial RVEs were generated with statistical data from metallographic images. FEM simulations of the micro indentation tests used the Gurson model and Rodriguez-Gutierrez equation. There is proposed a new parameter called spherical radius to quantify the closeness of the hard particles to the indenter tip. The simulated 3D curves were compared with respect to a reference curve of DP600, obtaining relative errors below 20 percent. Results show that the hard particles near the indenter affect the stress, strain, and micro void fields by changing the indentation response behavior. The spherical radius allows capturing the effect of the hard particles closeness because when its value is low, or the hard particles are closer to the indenter tip, the relative error of the average curve decreases due to the hard particles are constraining the deformation caused by the indenter in the material.
Performance Requirements on Laser Ignition System
Authors: S Shivakumar , G Veena B , R Kumarswamy
Published: January 2023

Abstract: Combustion is one of the most prominent energy conversion processes used in all areas of human life, even though it is being used on a large scale in various fields it has vital drawbacks like emission of greenhouse gases from IC engines majorly affecting the environment on a global level. One of the reasons of this issue being improper or inefficient ignition of the air-fuel mixture. However, this can be reduced to an extent by employing methods like lean combustion and re-circulating the exhaust gases. This is when the need of an alternative ignition system is required, one such concept being LASER IGNITION SYSTEM for internal combustion engines. On comparison laser ignition system provides number of potential benefits over conventional ignition by electric spark plug. Use of laser ignition system comes with advantages like- Reduction of NOx emission by 20% also improved efficiencies are obtained. The thermodynamic requirements of high compression ratios and high power density are fulfilled well by this system. Therefore, laser ignitors could replace conventional spark plugs in automobile industry. This not only provides better performance and fuel economy, but would also create less harmful emissions
Study and Analysis on Compressed Air Powered Vehicles
Authors: S Shivakumar , Anand Shubham , Kumar Shubham
Published: January 2023

Abstract: It is hard to believe that compressed air can be used to drive vehicles. However that is true,and the compressed air operated car, as it is popularly known, has caught the attention of researchers worldwide. It has zero emissions and is ideal for city driving conditions every automotive industry is looking to reduce the weight of the vehicle as it helps in the better handling of the vehicle and increases the efficiency of the vehicle. Today, the heavy vehicles are known for producing a large amount of harmful gases like CO2, SO2 etc. Although it seems to be an environmentally- friendly solution, one must consider its well to wheel efficiency. The electricity requirement for compressing air has to be considered while computing overall efficiency. Nevertheless, the compressed air vehicle will contribute to reducing urban air pollution in the long run.
A Comparative Thermal stability Study of N-(4-Nitropheny) Maleimide and N-(2, 4-di-nitrophenyl) maleimide with Methylacrylate
Authors: Meena Suresh Kumar , Singh Sanjeet
Published: January 2023

Abstract: In this article two type of monomers were synthesize, having different position on benzene ring one present on 4th position and second present on 2,4 position. Monomers were prepared by Maleic anhydride reaction with 2,4 dinitro aniline and 4 nitro aniline and obtained 4-Nitropheny Maleimide and 2,4-Didinitrophenylmaleimide copolymerized with Methylacrylate. Investigated a comparative study in between and what effect will come with thermal stability of the synthesis polymers. Free radical initiator AIBN and BPO were used of the polymerization and percentage yield calculated in THF and DMF solvent system under the identical conditions. Polymerization reaction proceed at different time (12, 24, 36) hours. Prepared homopolymer and copolymer were characterized by FTIR and 1H-NMR. The thermal stability and percentage degradation of the polymer were recorded by TGA Techniques. Percentage yield were obtained with given time hours and using free radical initiator and solvent systems. Synthesis polymers and their PDI values obtained range 1.5 to 10(Mw/Mn), it indicate that polymerization proceed via radical polymerization. Shape of the polymer in given solution were determined by Kuhan Mark Equations. Homopolymer shows unperturbed condition and copolymer present in rigid rods. Reduced viscosity and Intrinsic viscosity determined by the using Ubbelhod viscometer. Number average and weight average molecular weight were determined by the Gel permeation chromatography. Different feed mole ratios and percent yield were reported.
Cloud Computing Security
Authors: Joshi Prince , Dhangar Vishal , Muchhala Manish , Mandloi Surajbhan Singh
Published: January 2023

bstract: Cloud computing environment is a new way in which web base enable applications provide as a service for the users with low computational cost through internet. As we store data and it also provide services in distributed environment. Cloud ease its users byproviding virtualization technology of resources through internet. Cloud computing is the emerging field, due to this reason the various new techniques are still developing. At current scenario new security challenges were increases for cloud professionals. Due to lack of security in cloud computing environment user of cloud lost it trust in cloud. Multi-tenancy, elasticity, Security Performance and Optimization, etc. are various security issues in cloud computing. In this paper we will discuss some of the issue incloud. This paper also discusses some of the existing security technique for securing a cloud and help researchers and professionals to know about various security threats
Social childcare concept: Social community as a childcare partner for working parents
Authors: Kumalasari Devy , Alhasyimi Abdul Latif Arifin
Published: January 2023

In today's era, it has become easier for working parents to find childcare services because of the growing number of childcare institutions or services. However, limitations in a rural environment requires parents, especially working mothers to find childcare or caregiver substitutes in their social environment. This study aims to describe the concept of social care occurs in rural communities. This exploratory-descriptive qualitative research was carried out in Malang Regency, East Java, using the selected sample and snowball technique. The method used is semistructured interviews conducted with 3 people involved in childcare services for preschool children, and the data analysis model is taken from Miles and Huberman. The research results show that the social care concept has 3 dimensions: the mutually beneficial relationship of social exchange of childcarers and parents; carefree system of child care environment; and co-parenting mechanism. Partnership is performed voluntarily by offering the strategies used to find childcarers by increasing social cohesion in the community and involve children in activities with the social community. This study offers the strategies that can be implemented by working parents in finding childcarers in the social community by prioritizing informal kinship relations.
effect of grit on the work engagement of the millennial generation
Authors: Rusdi Muhammad , Purwaningrum Evi Kurniasari , Ramadhan Yoga Achmad
Published: January 2023

Employees of millennial generation are concerned about the sector since they are perceived to have less work engagement. This study used the positive psychology concept to empirically test the effect of grit on work engagement of 159 (N=159) millennial employees aged 20 to 40, with a minimum service period of one year. The method of this study was quantitative, and data collection used a questionnaire, namely the short version of the Utrecht Work Engagement Scale (UWES) and the Short Grit Scale (Grit-S), with 9 and 8 items for work engagement and grit, respectively. The sample used the purposive sampling technique, and the data were analyzed through a simple linear regression technique with the SPSS version 25.0 for windows. The analysis showed that grit positively affected work engagement with a value F(1.157) = 12.019, p = 0.001, R2 =0 .071, Radjusted = 0.065, and regression coefficient (β=0.603). The grit effect on work engagement was shown by the R square value of 0.071, meaning the grit variable of 7.1% influences the work engagement variation.
Investigation of the relationship between authoritarian personality and marriage readiness of emerging adult women
Authors: Utami Yasmin Adlina Heraputri , Muttaqin Darmawan , Wahyuningsih Sri
Published: January 2023

Emerging adulthood will experience a phase of self-exploration and enter married life. Therefore, individuals must have an authoritarian personality to adapt to changing roles and rules. Authoritarian personality supports individuals’ married life because they must be submissive and obey the rules, values, norms, etc. This research investigated the relationship between authoritarian personality and marriage readiness in emerging adult women (Respondents number (N) =196). The technique employed was purposive sampling. The research instruments used the Authoritarian Personality Scale and the Marriage Readiness Scale. This study applied the Pearson Product-Moment hypothesis testing method. The results revealed a positive correlation between authoritarian personality and marriage readiness (r=.415, p=0.000). Besides, authoritarian personality was also correlated with all aspects of marriage readiness. For individuals in emerging adulthood, it is necessary to understand that a submissive and obedient attitude can help them to be better prepared to face a new life, namely marriage.
Intolerance of uncertainty predicting work performance of indonesian temporary employees mediated by personal initiative
Authors: Yuniardi Muhamad Salis , Cant Matthew , Putri Aransha , Amalia Andi Nanda , Arumbiya Salsabila
Published: January 2023

Temporary employees in Indonesia have less certainty over their recent and prospective careers. This study aims to investigate whether the Intolerance of Uncertainty (IU) may predict personal initiative (PI) and subsequently affect work performance (WP). It was hypothesized that there was a direct and indirect relationship between IU and WP, through the PI.  The Purposive sampling technique was utilised in this research. The sample comprised 153 temporary employees who have been working in their current contract for more than six months Data was gathered through The Intolerance of uncertainty-12 items, Personal Initiative Scale, and Individual Work Performance Questionnaire and analyzed through Mediation analysis from PROCESS. The result reveals that IU does not have a direct relationship to WP (effect = -0.1450, p ­= .187), however, IU indirectly predicts WP through PI (effect = -0.1510, LLCI = -0.3251, ULCI = -0.0079). Temporary employees who report higher IU will have less PI (effect = -0.1254, p =0.0259), and eventually, their work performance will decrease (effect = 1.2042, p < 0.001). This research has some implications. First, during the employees’ recruitment process, the organisation need to consider the IU as a predictor of WP, and the government need to ensure that the companies abide by the Indonesian Labour Law – Act 13 of 2003 related to employees' welfare.
Peculiarities of the condition of the foundation slab of the pumped storage power plant water intake
Authors: Lisichkin Sergey E. , Kotitsyna Sofya S.
Published: January 2023

The authors present the results of the analysis of field observations of the condition of the base slab of the water intake structure of hydroelectric power plant (including the stresses in the reinforcement in the areas of intersection with the vertical joints and the width of the opening of these joints). The aim of the study is to control the condition of the reinforced concrete structure of the foundation slab of the water inlet of the hydroelectric power plant, as well as to develop measures to strengthen the bottom section of the foundation slab in the areas of vertical interblock joints. In order to control the stress and strain of the base plate of the water intake of hydroelectric power plant, string control and measuring equipment was installed: on reinforcement rods - reinforcement dynamometers PSAS, on vertical interblock joints - displacement sensors PLPS. The field observations of the stress state of the reinforcement of the base slab of the water intake structure of hydroelectric power station showed that high values of tensile stresses, exceeding the design resistance of A500C class reinforcement (435 MPa), occurred in the reinforcement rods (directed along the flow), crossing the lower vertical interblock joints. There was also fixed the width of opening of the vertical interblock joint, reaching 1.28 mm. There was a necessity to strengthen the lower section of the foundation slab of the water intake structure of hydroelectric pumped storage power plant. For this purpose, inclined reinforcing bars (anchors) crossing the lower vertical interblock joints were installed. The outlet sections of the buttresses of the slab of the downstream section of the inlet to the downstream parapet were increased.
Couplings slip determination of the threadbar of strength class 500 N/mm2
Authors: Grishin Grigorii E. , Tikhonov Georgy I. , Savrasov Ivan P. , Okolnikova Galina E.
Published: January 2023

The authors present the results of RD on the topic of coupling slip of threadbar of class Av500P. The aim of the work was to obtain experimental data to study the effect of the threadbar coupling on the slip (deformability) of the joint and taking into account the characteristics of the joint in the design of structures. The strength and deformability of coupling samples of threadbar with a diameter of 16, 25 and 40 mm with an innovative four-sided (four-row) thread profile of class Av500P have been studied in accordance with the methodology of international and Russian standards. The samples were made with different tightening torques of the lock nuts and anchor-adhesive compositions inside the coupling. Along with the results of the study, it can be concluded that these couplings of innovative four-row threadbar of class Av500P meet the requirements of international and Russian standards when applying a certain tightening torque to the tightened lock nuts, depending on the diameter of the fittings to be joined and the use of anchor-adhesive compositions on large and medium diameters of the threadbar to be joined. The diagrams of thread joints obtained during the experiment can be used in design practice when design reinforced concrete structures according to the deformation model. Together, this makes it possible to introduce thread joints into the Russian construction regulatory code.
A PANDEMIA DO NOVO CORONAVÍRUS E A CRISE EXPLÍCITA DA HEGEMONIA NORMATIVA
Authors: Chaves dos Santos Arthur Dartagnan
Published: January 2023

A segregação socioespacial, intrínseca à sociedade de classes, está intimamente conexa a um pluralismo multiplanar: cultural, social e jurídico, dentre outros. Dessa forma, a lógica centro-periferia deriva a cidade em muitas, as quais se submetem a realidades e dinâmicas distintas. O pluralismo jurídico, portanto, revela-se como intransigência dos ora espaços opacos à norma emanada pelo Estado, vez que carece de lógica ou coerência material.
MOBILIDADE POPULACIONAL REALIZADA POR ESTUDANTES DO ENSINO SUPERIOR EM MOSSORÓ-RN
Authors: Almeida Rodrigo Emanoel de Sousa
Published: January 2023

Os fluxos de estudantes do ensino superior em direção a Mossoró têm colaborado para a dinâmica populacional local. A cidade compõe um quadro de oferta de cursos em instituições (privadas e públicas) diversas, atendendo à demanda por essa modalidade de ensino no estado do Rio Grande do Norte, bem como no Ceará e demais unidades federativas do país. Com isso, o objetivo deste trabalho foi identificar os tipos de mobilidades realizadas por estudantes e os fatores que condicionam as suas ações. A pesquisa se pautou na coleta de dados primários e na obtenção de dados secundários, conduzindo, assim, a uma abordagem quantitativa e qualitativa, por meio de uma discussão de cunho teórico. Foi constatado que os deslocamentos ocorrem em períodos predefinidos, sejam diariamente, semanalmente, quinzenalmente e (ou) sazonalmente, variando de acordo com distâncias, custos, acessibilidades e oportunidades de acesso ao ensino superior, sendo assim definidos diante das condições socioeconômicas dos estudantes.
GEOGRAFIA DECOLONIAL DA PANDEMIA
Authors: Porto-Gonçalves Carlos Walter , Rocha Pedro Henrique , Trindade Helena
Published: January 2023

Este trabalho busca analisar a pandemia provocada pela COVID-19 (Coronavirus Disease 19) no ano de 2020 a partir de uma leitura decolonial dos seus acontecimentos. Compreendendo as assimetrias das relações sociais e de poder, buscou-se analisar quais os impactos e os efeitos do coronavírus nos territórios e nas diferentes geografias, sobretudo em uma escala de análise global, e quais os impactos e os efeitos do vírus foram agravados pelos discursos e ações coloniais.
MERCADO DA VILA RUBIM
Authors: Assis Kamilly Antunes de , Rios Gabriela Leal
Published: January 2023

O presente trabalho realiza uma análise sobre os processos de atribuição de significados de valorização e desvalorização através da paisagem, especificamente no Mercado da Vila Rubim, em Vitória, Espírito Santo. Levamos em consideração o importante papel que a mídia desempenha na construção de discursos que se desdobram, possivelmente, em significações espaciais. Foram, então, levantadas uma série de notícias que embasaram a seleção de alguns eventos como processos marcantes de construção de um imaginário sobre o local, nos quais se identificam de forma notável, movimentos simultâneos de valorização e desvalorização da paisagem. Sendo assim, buscou-se discorrer sobre as motivações que embasaram a mobilização destes discursos que aparecem de forma, também, a justificar modificações efetivas na paisagem.
ANÁLISE DA MIGRAÇÃO INTERNA DA MESORREGIÃO DO TRIÂNGULO MINEIRO E ALTO PARANAÍBA NOS PERÍODOS 1995-2000 E 2005-2010
Authors: Amaral João Benvindo , Alvim Ana Márcia Moreira
Published: January 2023

Esta pesquisa tem como objetivo central analisar a migração interna na Mesorregião do Triângulo Mineiro e Alto Paranaíba – MRTMAP, nos períodos de 1995-2000 e 2000-2010. A justificativa está alicerçada na importância da região, tanto no contexto regional, como no estadual e nacional, sendo oportuno compreender sua migração interna, por meio de sua Taxa Líquida e Eficiência Migratória. Em termos metodológicos o trabalho foi organizado em três etapas: i) consulta e análise de um referencial teórico acerca do conceito de migração; ii) coleta de dados de migração, disponibilizados pelo IBGE, para os anos de 2000 e 2010 e, iii) tratamento destes, por meio dos softwares: Statiscal Product and Service Solutions – SPSS e Arcgis versão 10.1. Como resultados alcançados pôde-se destacar que a região central da MRTMAP é a mais dinâmica em relação à migração, sendo seguida das regiões oeste e leste; e que a maior parte dos municípios da região tem perdido habitantes para municípios de porte demográfico maior, o que pode impactar negativamente no desenvolvimento regional da MRTMAP.
DINÂMICA DO FLUXO MIGRATÓRIO DE POPULAÇÃO COM ALTO GRAU DE INSTRUÇÃO EM DUAS REGIÕES METROPOLITANAS BRASILEIRAS
Authors: Rodrigues Rennan Moraes , Oliveira Rachel Facundo Vasconcelos de , Dos Santos Yago Oliveira
Published: January 2023

Este artigo buscou tratar sobre os fenômenos migratórios, levando em conta fatores econômicos associados com o debate inserido numa análise macroestrutural. Nesse sentido, serão apresentadas reflexões sobre o deslocamento de pessoas qualificadas, aquelas com ensino superior completo e que atuam em ocupações relacionadas à sua formação, tendo como recorte as qualificadas que vivem na Região Metropolitana de Fortaleza (RMF) e na Região Metropolitana da Grande Vitória (RMGV). Como metodologia, utilizaram-se os dados do Censo Demográfico de 2010, a partir de suas variáveis de migração data fixa, renda, escolaridade, faixa etária, condição de moradia (habitação própria quitada ou financiada, alugada ou outras condições), tempo de moradia, preço médio de aluguéis em salários mínimos e distribuição espacial dos migrantes segundo local de moradia. Com base nos resultados, foi possível destacar o comportamento dos migrantes qualificados e não qualificados na produção do espaço em ambas as metrópoles, utilizando as informações sobre preço do aluguel e as condições de moradia. Espera-se que o artigo apresente contribuições relevantes sobre o debate envolvendo migração, população qualificada e produção do espaço no Brasil.
ESPORTE, CIDADE E GEOGRAFIA
Authors: Mattos Lucas Nascimento de , Rosalin João Paulo , Franco Fernando Chamone , Bezerra Rafael Freitas , Santos Leandro Luís Lino dos , Ferreira Jonathan
Published: January 2023

Entrevista com Victor Andrade de Melo, professor da UFRJ e coordenador do Sport: Laboratório de História do Esporte e do Lazer.
Formação continuada na educação infantil
Authors: Barbosa Marta Cristina , Dos Santos Bernardi Luci
Published: January 2023

O presente estudo, de cunho bibliográfico, reflete sobre ações de formação continuada para professores/as que têm como lócus o ‘chão’ da escola: a Formação Continuada Centrada na Escola, experiência da Rede Municipal de Educação de Rondonópolis/MT. Destaca a especificidade do/a docente e seu trabalho na educação infantil, colocando em pauta os diferentes elementos necessários para o desenvolvimento das práticas pedagógicas; a Formação Continuada Centrada na Escola e sua importância na construção da identidade e no desenvolvimento profissional docente; e os novos desafios em tempos de ensino híbrido/remoto. Os aportes teóricos permitem compreender a escola como espaço de formação pedagógica continuada do/a professor/a, não se dando de forma individual, mas na articulação com os/as demais profissionais da escola, em busca constante da transformação de práticas pedagógicas, da construção de identidade, do desenvolvimento profissional e da cidadania.
“Homem não rebola”; “Essa menina contamina as colegas”
Authors: Assunção Alves Zozias Lima Rosemeiry , Mazzeo Mariano Jorge Luís
Published: January 2023

O presente artigo busca promover a reflexão sobre gênero, educação e direitos humanos, discutindo e problematizando as relações de gênero, bem como as aprendizagens no cotidiano escolar sobre a produção das diferenças e desigualdades com base nas representações naturalizadas de masculinidades e feminilidades. Trata-se de um estudo bibliográfico, de abordagem qualitativa, com aporte teórico de autoras/es como Joan Scott, Guacira Louro, Constantina Xavier Filha, Vera Candau, Norberto Bobbio , Maria da Glória Gohn, entre outros/as. Os resultados apontam a escola como lugar potente para difundir uma cultura dos direitos e o convívio em direitos humanos, para perceber, conhecer e vivenciar as pluralidades inerentes aos sujeitos.
Educação em Prisões no Espírito Santo
Authors: Demuner Ribeiro Flávia , Ventorim Silvana , Ricas de Oliveira Dalva
Published: January 2023

Este artigo analisa a relação entre condição docente e formação continuada de educadores/as da Educação em Prisões, no estado do Espírito Santo, durante a pandemia da COVID-19. Usa abordagem quali-quantitativa, com recursos da pesquisa exploratória-documental na aplicação de questionário semiestruturado (Google Forms) a 336 educadores/as que atuam na Educação em Prisões no Espírito Santo. Foi constatado que esses/as educadores/as traduziram suas concepções durante o processo de formação continuada, indicando a necessidade de formação permanente e de reflexão sobre os modelos de formação. Conclui-se que a formação permanente e crítica associada a políticas de valorização profissional e à concepção sócio-histórica de educador é o caminho possível para que os/as educadores/as construam alternativas de emancipação, garantindo a educação como elemento de justiça social e cidadania.
Condição do trabalho docente
Authors: Lievore Sue Elen
Published: January 2023

O presente artigo analisa a constituição da categoria docente como classe trabalhadora no contexto de desmonte dos direitos sociais, notadamente a partir de 2016. Para tanto, apresenta e discute dados de uma pesquisa realizada entre 2019 a 2021, coletados em entrevista semiestruturada junto a 12 professores/as e um survey respondido por 204 docentes de ensino médio de uma rede pública de ensino. Na experiência desses/as professores/as, é possível perceber que demonstram disposição para constituírem-se como classe, na medida em que refletem sobre suas condições de vida e trabalho, reconhecem a relevância e aderem aos instrumentos de luta coletiva constituídos historicamente pela classe trabalhadora na defesa de uma educação pública e de qualidade.
Desobedecer para transformar
Authors: Dalmaso-Junqueira Bruna
Published: January 2023

O presente artigo, recorte de uma pesquisa mais abrangente ainda em andamento, aborda a necessária, criativa e transformadora prática feminista desenvolvida por docentes da educação básica brasileira. Diante de uma crise política, societária e pedagógica, num cenário pós-pandêmico, digital e de uma forte onda conservadora, há iniciativas de resistência respondendo aos ataques e desafios que a categoria enfrenta. Através de referenciais dos estudos educacionais críticos, dos feminismos e da ferramenta teórico-metodológica da Análise Relacional, faz-se a análise da prática de avaliação diagnóstica/dinâmica de integração de ume professore da rede estadual de ensino no interior de São Paulo. Essa prática aparentemente simples desobedece à norma hegemônica da educação tradicional e da sociedade. Nela foram observados elementos feministas, como constituição de comunidades de aprendizagem; inversão da hegemonia, centralizando no processo educativo experiências de grupos vulnerabilizados; envolvimento respeitoso e engajado de docente e discentes; legitimação de identidades dissidentes; e comprometimento coletivo com o combate às desigualdades decorrentes do preconceito.
Mecanismos fiscales en el marco de la COVID-19: una mirada a las desigualdades económicas en América Latina
Authors: Aguirre-Ríos Albeiro , Espinal Piedrahita Juan José , Cabrera Jaramillo Ruby Stella , Vélez Escobar Sol Beatriz
Published: January 2023

El objetivo del presente artículo fue identificar las políticas fiscales implementadas en América Latina, sus efectos y el enfoque en la visualización de las desigualdades económicas en el marco de la pandemia originada por la COVID-19. Para tal propósito, la metodología desarrollada consistió en la revisión de literatura de los años 2020 y 2021 en las bases de datos especializadas Scopus y Redalyc en investigación y estadísticas temáticas; para ello, se tomaron como muestra los países con mayores resultados en cuanto a investigaciones realizadas: Argentina, Brasil, Chile, Colombia, Ecuador, México y Perú. Los resultados indicaron que, aunque las estructuras tributarias en estos países son similares, el mayor recaudo, en años recientes, estuvo en Brasil y México; en cuanto a las medidas tomadas en política fiscal y monetaria, la mayor cantidad fueron implementadas por Brasil y Colombia; en lo referente al gasto social como porcentaje del producto interno bruto (PIB), la región estuvo por debajo del promedio en comparación con países de diferentes niveles de ingreso, a excepción de Brasil y Argentina, que contaban con el 31,8 % y 30 %, respectivamente. Cabe destacar, como conclusión, la problemática en la estructura fiscal que quedó en evidencia con la pandemia en los países en vías de desarrollo y la neutralidad de los mecanismos fiscales al no provocar efectos positivos frente a las desigualdades económicas.
Social responsibility accounting and financial performance during COVID-19: A survey of the firms listed in Amman Stock Exchange
Authors: Shahwan Yousef , Hamza Mohyedin , Lubad Husam Khalel , Khresat Ola Muhammad
Published: January 2023

The need to activate the concept of social responsibility accounting has increased, especially in light of the difficult economic challenges and the increase in competition between companies (Shahwan et al., 2022a). This study aims at identifying the impact of applying social responsibility accounting on the financial performance of public shareholding companies listed on the Amman Stock Exchange (ASE) during the COVID-19 pandemic. To achieve the aim of this study, the researcher developed a questionnaire, where the study population consisted of public shareholding companies and the population was 173 companies according to the ASE. In this study, questionnaires were used to collect the data, and the Statistical Package for the Social Sciences (SPSS) used to analyze the data. This study finds that there is a significant impact of social responsibility accounting on the financial performance represented by the return on assets for public shareholding companies listed on the ASE during the COVID-19 pandemic. This study recommended that there is a need for public shareholding companies to work to apply the activities related to social responsibility accounting in its various dimensions (employees, environment, society, and product). In addition, the companies should work to meet the desires of all members of society, which will lead to an increase in the community’s confidence in the company, and this will reflect positively on its financial performance in general and the return on assets specifically.
Transient sound
Authors: Alicia Lazaro Arteaga
Published: January 2023

Art, and music, have the capacity of placing us in front of the symbolic. They bring us closer to everything we cannot understand in a rational manner, allowing us to see ourselves from the inside. Going back to the notion of music as a transformative ritual, a role that has had along centuries in most societies. Music as a sacred space.

This exposition explores the relationship between music and text. Placing the idea of narrative as part of the music, connecting storytelling with sound. By using folklore stories as a structural element in the composition process, I have attempted to grasp the emotional landscapes inside of the tales and translate them into music. This process has been crystallized into several pieces that show the path between the starting point, which was using a text to create music, and the broader conception of music as an experience that involves not only sound but images, space, and movement.
Evaluation of time to onset and outcome of cardiac adverse events related to pembrolizumab using post-marketing surveillance
Authors: kanbayashi Yuko , Tsuchiya Eren , Akiba Hitomi , Shimizu Tadashi , Uchida Mayako
Published: January 2023

Aim: The present study aimed to evaluate time to onset,
incidence rates, and outcomes for pembrolizumab-induced cardiac adverse
events (AEs) in patients with cancer using the Japanese Adverse Drug
Event Report database. Methods: We analysed data for the period
from April 2004 to March 2022. Data on cardiac AEs were extracted and
relative risks of AEs were estimated using the reporting odds ratio.
Results: We analysed 2,021,907 reports and identified 15,306
reports of AEs caused by pembrolizumab. Of these, 399 cardiac AEs were
associated with pembrolizumab. Signals were detected for six cardiac
AEs: myocarditis, immune-mediated myocarditis, pericardial effusion,
cardiac tamponade, pericarditis, and pericarditis malignant. A histogram
of median times to onset showed occurrence from 33 to 138 days, but some
cases occurred even more than 1 year after the start of administration.
Among these, myocarditis was the most frequently reported (27.1%), with
fatal cases also reported. Conclusion: This study focused on
cardiac AEs caused by pembrolizumab as post-marketing AEs. Some cases
could potentially involve serious outcomes, so patients should be
monitored for signs of onset of these AEs not only at the start of
administration, but also over an extended period, especially for
myocarditis.
Flexible peptide linkers display higher resistance to proteolysis than rigid linkers by facilitating movements that inhibit the approach of proteases
Authors: Guptasarma Purnananda , Waghmare Snehal
Published: January 2023

The differential proteolytic susceptibilities of different types of
linkers joining the same two protein domains were investigated, to
identify linkers displaying the highest resistance to degradation by
proteases in the environment. Five linkers, namely Rigid [3
repeats of EAAAK], Flexible [two repeats of SGGGG],
Nat-Full, Nat-Half and Nat-Quarter [3 linkers of
42, 21, and 9 residues, respectively, derived from a naturally-occurring
Coh2-adjacent sequence] were used to fuse two thermostable, and
proteolytically-resistant, domains, namely Coh2 (from C.
thermocellum CipA), and BSX (from Bacillus sp. NG-27). The
produced fusions were examined for linker degradation, using
electrophoretic (SDS-PAGE) and chromatographic (size exclusion)
experiments, following different periods of storage at 4 ⁰C.
Rigid, Nat-Full, Nat-Half and Nat-Quarter were degraded,
and released free Coh2 and BSX. However, Flexible displayed a
remarkable resistance to both environmental proteases and Subtilisin A
(a non-specific protease). Our data suggests that Flexible
imparts freedom of movement to Coh2 and BSX, and then reciprocally
receives protection against proteolysis from Coh2 and BSX, through their
dynamic steric inhibition (or ‘batting away’) of protease approach.
Clinical evidence of the effectiveness of remdesivir in COVID-19 during periods dominated by Delta and Omicron SARS-CoV-2 variants.
Authors: Zarębska-Michaluk Dorota , Dobrowolska Krystyna , Brzdęk Michał , Rzymski Piotr , Rogalska Magdalena , Moniuszko-Malinowska Anna , Kozielewicz Dorota , Hawro Marcin , Rorat Marta , Sikorska Katarzyna , Jaroszewicz Jerzy , Kowalska Justyna , Flisiak Robert
Published: January 2023

Continuous evaluation of real-world treatment effectiveness of COVID-19
medicines is required due to the ongoing evolution of SARS-CoV-2 and the
possible emergence of resistance. Therefore, this study aimed to analyze
the outcomes in patients hospitalized with COVID-19 during the pandemic
waves dominated by Delta and Omicron variants and treated with
remdesivir (RDV) (n=762) in comparison to the demographically and
clinically matched group not treated with any antivirals (n=1060).
During the Delta wave, the RDV-treated group revealed 2-fold lower
mortality (10.8 vs. 23.2%, p<0.001) and 1.5-fold lower during
the Omicron-dominated period (11.4 vs. 16.8%, p=0.05). RDV-treated
groups were characterized by a lower percentage of patients requiring
mechanical ventilation, but the difference was not statistically
significant. This study is the first real-world evidence that RDV
remains effective during the dominance of more pathogenic SARS-CoV-2
variants and those that cause a milder course of the disease and
continues to be an essential element of COVID-19 therapy.
Application and development of Construction Robot
Authors: 李 朋昊 , Xu Tiannan , Hu Yubing
Published: January 2023

Introduction With the rapid acceleration of the economic
construction，the recent years have witnessed a huge development in the
building industry． Based on the characteristics of the building
industry，the technology of industrial robot has been introduced and the
development of building robots has become an inevitable trend with
pertinences． Methods In combination with the aspects of
mechanical structure and control system and so on，the present situation
of application and study of wall construction robots，decoration
construction robots，maintenance construction robots，rescue
construction robots and 3D printing construction robots at home and
abroad are systematically reviewed in this paper．At the same time，from
the aspects of structure design，sensor technology，navigation ＆
positioning technology and control system and so on. Conclusion
out the future developmental direction of building robotics －－
integrating high－precision, lightweight design, intelligence and other
features．
A stable time-dependent mesh method to analyze the linear advection-diffusion equation
Authors: Sultan Saad , Zhengce Zhang , Usman M.
Published: January 2023

This paper develops the stable adaptive time-dependent mesh scheme for a
one-dimensional linear advection-diffusion equation with homogeneous
Dirichlet boundary conditions and a sinusoidal initial condition. The
aim is to present accurate stable moving nodes finite difference scheme
with its stability and convergence. The boundary layer of the flow is
exponential therefore difference scheme needs mesh refinement. The
moving mesh method analyzes the problem physics and adjusts the mesh
according to the problem as it moves nodes in the region of edges. We
develop numerical results using four MMPDEs with varying numbers of
nodes. A conservative semi-discretization finite difference scheme is
used for the spatial derivative and backward Euler difference scheme is
employed for the temporal derivative. We have presented five cases in
detail to understand the physics of the problem. The proposed moving
mesh finite difference method is considerably more efficient than the
numerical methods offered in the literature.
Redefining probability of preeclampsia in high risk women using PlGF later in pregnancy
Authors: Kumar Manisha , Balyan Kirti , Y Benchumi Humtsoe , Meena Bhawana , Sapna Surbhi , Rana Anjali
Published: January 2023

Objective: To determine the effectiveness and gestational
age-specific cut-off of Placental growth factor ( PlGF) in the second
half of pregnancy for the prediction of adverse materno-fetal outcome
among high-risk women. Methods: This secondary analysis
explored associations between placental growth factor (PlGF) among women
at high risk of PE at 20-22, 28-30, and 34-36 weeks of gestation. Women
were divided into two groups based on PlGF levels cut-off derived after
applying area under the receiver operating curve. Results: Of
the 287 high risk women, 116(40.4%) had preeclampsia (PE). The cut off
of PlGF was 224pg/ml, 211pg/ml and 176 pg/ml at 20-22, 28-30 and 34-36
weeks respectively, nearly 30% of the high risk women had PlGF below
cut-off. The sensitivity and specificity of PE prediction using PlGF at
20-22 weeks was 81.0% and 72.2% respectively. For PlGF done at 28-30
weeks, the sensitivity and specificity of PE prediction till 32 weeks
were 91.7% and 78.5% respectively. For PlGF done at 34-36 weeks, the
sensitivity and specificity of PE prediction till 37 weeks was 95.8%
and 73.3%, respectively. The negative predictive value of the PlGF at
any gestation was nearly 90% or above for PE prediction till delivery.
The accuracy of the test was highest at 28-30 weeks and for prediction
before 37 weeks. Conclusion: The PlGF is a good marker to be
done at 28-30 weeks for prediction of PE especially early onset and its
adverse outcome; it can also be done at 34-36 weeks for preterm PE
prediction.
Binding interactions of actinomycin D anticancer drug with bile salts micelles
Authors: Toader Ana , Dascalu Izabella , Neacsu Elena , Enache Mirela
Published: January 2023

The interactions of actinomycin D (ActD) anticancer drug with two bile salts of different hydrophobicity (sodium cholate (NaC) and sodium deoxycolate (NaDC) and the influence of these bile salts aggregates on the ActD?DNA complex was investigated in 10 mM phosphate buffer (pH 7.4) by UV?Vis spectroscopy (absorption and thermal denaturation). The binding strength of ActD to NaDC is higher than for NaC, and this difference attests stronger hydrophobic interactions between ActD and NaDC micelles. Also, the partition coefficient is significantly higher for NaDC micelles than for NaC micelles, in line with larger aggregates formed by NaDC. The spectral profile of ActD molecules in NaC and NaDC micelles, in comparison with different solvents, implies that ActD molecule experiences a hydrophobic environment in bile salts aggregates. Regarding the influence of NaC and NaDC aggregates on the ActD?DNA complex, it was shown that the presence of both bile salts micelles do not induce the deintercalation of ActD molecules from DNA duplex.
Pharmacokinetics and Pharmacodynamics of a Novel U500 Insulin Aspart Formulation: A Randomized, Double-Blind, Crossover Study in People With Type 1 Diabetes
Authors: Svehlikova Eva , Ashcroft Nicole L. , Gatschelhofer Christina , Gerring David , Höller Vera , Jezek Jan , Lackner Bettina , Lawrence Fiona , Pillai Vijay , Ratzer Maria , Urschitz Martina , Wolf Michael , Pieber Thomas R.
Published: January 2023

  

OBJECTIVE

To evaluate the pharmacokinetics, pharmacodynamics, and safety of a novel U500 insulin aspart formulation (AT278 U500) compared with insulin aspart (IAsp U100).

RESEARCH DESIGN AND METHODS

This single-center, randomized, double-blind study was conducted in 38 men with type 1 diabetes (body weight ≤100 kg and total insulin dose <1.2 units/kg/day). Participants received a single dose of either AT278 U500 or IAsp U100 (0.3 units/kg subcutaneously) in a crossover design, followed by an 8-hour euglycemic clamp in the absence of basal insulin.

RESULTS

With AT278 U500, onset of appearance in serum was 6 min earlier (P <0.0001) and reached 50% of maximum concentration 23 min faster (P <0.0001). Insulin exposure with AT278 U500 was 4.0-fold higher within the first 30 min (95% CI 3.29; 4.90), 1.5-fold higher within the first 60 min (95% CI 1.35; 1.76), and statistically superior up to 90 min postdose (P <0.05). With AT278 U500, onset of action was 10 min earlier (P <0.0001) and reached 50% of maximum glucose infusion rate 20 min faster (P <0.0001). The glucose-lowering effect with AT278 U500 was 8.9-fold higher within the first 30 min (95% CI 5.96; 17.46), 2.4-fold higher within the first 60 min (95% CI 1.92; 3.22), and statistically superior up to 2 h postdose (P <0.0001). Overall insulin exposure and glucose-lowering effect were comparable. No significant safety findings were observed.

CONCLUSIONS

AT278 U500 offers rapid-acting characteristics in a reduced dose volume, with accelerated absorption and onset of action compared with IAsp U100 in the studied population.