bluuebunny/crossref_metadata_2025 huggingface dataset:
Public Service Through Online Single Submission: Efforts to Simplify Investment Licenses in Improving Public Service
Authors: Sinulingga Tommy Aditia , Satoto Sukamto , Sirait Ningrum Natasya , Affila
Published: April 2024

Public service is a form of service that is principally the responsibility of and implemented by Government Agencies. One form of public service carried out by the government is related to investment licensing, namely through Online Single Submission (OSS). Online Single Submission (OSS) is a Business License issued for and on behalf of the minister, head of institution, governor, or regent/mayor to Business Actors through an integrated electronic system. However, the concern is whether Online Single Submission (OSS) will facilitate investment licenses or instead make it difficult in public services and whether Online Single Submission (OSS) is sufficiently safe, reliable and protected by law.This research is a normative juridical research, which is a legal research method carried out by examining library materials or secondary materials such as laws and regulations, books, legal rules and literature related to the formulation of this research problem. The data used is secondary data, which is obtained from primary legal materials, secondary legal materials and tertiary legal materials. The data collection method used in this research is library research by tracing, reading, studying or analyzing materials, theories and concepts. The making and issuance of investment license decree is a legal action of the government. As a legal action, there must be authority granted by legislation or it must be based on the principle of legality. The matter of investment license is regulated in Law No. 23 Year 2014 on Local Government, Law No. 25 Year 2007 on Investment is obtained. Online Single Submission has been categorized as providing improvements in public services but still must receive attention from the government.
Reversal of Burden Proof as a Reform of Criminal Law Eradicate Money Laundering
Authors: Azizah Hanifah , Santoso Topo , Husein Yunus , Mulyadi Mahmud
Published: April 2024

One of the efforts of the Indonesian government in reducing money laundering is to pay special attention in terms of proof, namely with the reverse proof system.  Over time, the reversed proof system in the Corruption Law is still regulated even though the Corruption Law has undergone many changes. Although it has been included in positive law, in practice this proof is not applied thoroughly and there are still obstacles in its application. This research seeks to answer in what cases the reverse burden of proof is applied and what are the obstacles in its application. This type of research is normative juridical. The results of the study resulted in the merging of corruption cases with money laundering can be considered to provide its own advantages in handling corruption cases. More actors are ensnared including corporations. Maximum punishment, streamlining the return of state assets can impoverish corruptors. Legal culture that has not adapted to the new system, reverse evidence is not clearly regulated in the law.
An Overview of Intellectual Property Rights as Waqf in Indonesia and Malaysia
Authors: Yuswar Cheryl Patriana , Runtung  , Maulana Insan Budi , Azwar T. Keizerina Devi
Published: April 2024

This paper aims to get an overview of Intellectual Property Rights as waqf in Indonesia and Malaysia. To achieve these goals, the research uses a normative legal writing method with descriptive-analytical specifications. The findings reveal, both Indonesia and Malaysia permit IPR being waqf. Unfortunately, there are no implementing regulation or specific guidelines regarding how and what to waqf from IPR in both states. The absence of implementing regulation or guideline will have implication not only for confusion in the community, but also for the lack of applicability of IPR being waqf in the community.
DIGITALIZATION OF THE ACTIVITIES OF THE STATE CRIMINAL AND EXECUTIVE SERVICE OF UKRAINE UNDER THE CONDITIONS OF MARTIAL LAW
Authors:   Institute of Professional Development,  Academy of the State Penitentiary Service,  Chernihiv, Ukraine, Zaluhovska H. , Barakhta V. ,   Institute of Professional Development,  Penitentiary Academy of Ukraine,  Chernihiv, Ukraine, Kosov O. ,   Institute of Professional Development,  Penitentiary Academy of Ukraine,  Chernihiv, Ukraine
Published: April 2024

The article analyzes the concept of “digitalization” and its significance for the functioning of the state. The positive changes, which is the result of the implementation of digitalization in Ukraine during the war, as well as its significance in the post-war period, are outlined in the article. An analysis of the state of digitization of the procedures for providing and receiving public services was carried out. The article studied the results of the introduction of the latest information technologies into the daily activities of civil servants in Ukraine. The main modern scientific approaches to determining the advantages of digitization in Ukraine are highlighted. A number of factors, both general and special, which can affect the implementation of digitalization in Ukraine have been identified. An analysis was carried out regarding the legal acts accompanying the process of digitalization of state authorities in Ukraine. Current problems of digitization in the system of bodies and institutions for the execution of punishments, pretrial detention centers and higher educational institutions with specific learning conditions of the State Criminal and Executive Service of Ukraine are indicated. The tasks defined by the Penitentiary System Reform Strategy for the period until 2026 regarding expanding the possibilities of digitalization of the penitentiary system of Ukraine were studied. The authors proved that the introduction of digitalization into the work process of the personnel of the State Criminal and Executive Service of Ukraine will increase the efficiency of the activities of the rank and command staff and employees of the State Criminal and Executive Service of Ukraine, as well as ensure the compliance of the technological processes taking place in the penitentiary system with the modern requirements of Ukrainian society. Specific proposals for making changes to the Penitentiary System Reform Strategy for the period until 2026 with the aim of supplementing the areas of implementation of digitalization in the activity of the penitentiary system of Ukraine were proposed. Proposed solutions regarding the implementation of progressive technologies in the activities of bodies, institutions for the execution of punishments and detention centers of the State Criminal and Executive Service of Ukraine in the field of recruiting. Key words: State Criminal and Executive Service of Ukraine, personnel, personnel selection, digitalization, reformation.
THE STATE OF SCIENTIFIC RESEARCH OF CRIME IN THE FAMILY SPHERE
Authors:   State University “Zhytomyr Polytechnic”, Zhytomyr, Ukraine, Bohatyryov I. , Buriak K. ,   Ukrainian State University of Chemistry and Technology, Dnipro, Ukraine
Published: April 2024

The article reveals the need to study crime in the family sphere in the works of Ukrainian scientists. This can be explained by the fact that it is criminological science that investigates such crime as a system with exceptionally complex types of criminal offenses committed by the offender during their common life. So, there is a significant need for a scientifically based and comprehensive analysis of this crime and the development of effective forms and methods of its prevention, because the family is constantly in social relations with the state and its institutions. These relationships are based on social ties that unite people into a functional whole, while creating equality and inequality in the rights and obligations not only of spouses, but also within the social group of society. It was noted that among the criminological problems of crime in the family sphere in Ukraine, the problem of domestic crime, which in most cases was and remains the most latent among other criminal offenses, became the agenda. And therefore, recognizing the family as the center of society, it should be noted that without the support of the state and its institutions, unfortunately, the problem of crime in the family sphere is almost impossible to solve. And this is due to the fact that the family is not always able to fulfill its main function – ensuring the proper well-being and upbringing of children. History shows that the main types of crime in the family sphere are: domestic, economic, psychological, sexual and physical violence. Taking into account that there is a war in Ukraine, the problem of criminalization in the family sphere takes on special importance, and we consider it as an object of criminal offenses committed by the offender. The consequence of this is the divorce of husband and wife, a decrease in the standard of living of children, their lack of protection, poverty, and the weakening of the infrastructure of health care, education and culture. Key words: criminal offenses in the family sphere, offender, family violence, marital conflict.
Development of the Indigenous Health Toolkit
Authors: Lewis Melissa , Modde Elizabeth , Kamaka Martina , Maresca Terry , Horner Melissa , Hudson Stan , Myhra Laurelle
Published: April 2024

Indigenous patients frequently experience bias and racism in society and within medical encounters. Biased health care relates to delayed and worsened health care, as well as worse health outcomes. Evidence exists that training can reduce bias and improve care. However, no recommendations or requirements around Indigenous health education exist. Therefore, a team of 7 experts was formed to create a training guide called the Indigenous Health Toolkit to train healthcare providers to provide more effective care to Indigenous patients. Indigenous methodologies were applied to this endeavor to create recommendations and training which included engagement with Indigenous elders, community, youth, and businesses. A 7-module toolkit was created over one year to train healthcare providers to provide culturally congruent and bias-free care to Indigenous patients in hopes of reducing the gap in health disparities that exists between Indigenous and non-Indigenous communities.
Los influencers en las redes sociales: Una mirada desde la propaganda electoral y política en veda electoral
Authors: Timal López Sandra
Published: April 2024

En los últimos procesos electorales de México se han presentado situaciones en las que personajes con un alto número de seguidores en redes sociales invitan a las personas a votar por determinadas candidaturas en tiempos de veda electoral, situación que merece ser regularizada legislativamente en el país. Este artículo retoma conceptos en torno a la propaganda electoral y política y la libertad de expresión, con el objetivo de contextualizar al lector en el escenario político y reconocer sus exigencias. Para su desarrollo se empleó investigación documental con el uso del método inductivo, y se retomaron casos representativos y juicios que sientan precedentes respecto al objeto de estudio.
Pengaruh Public Relation dan Customer Value Marketing Terhadap Customer Loyalty di Janji Jiwa Poris
Authors: Sani Muhamad Fikri , Vandayuli Riorini Sri
Published: April 2024

This study intends to ascertain the impact of customer value marketing and public relations on customer loyalty promise Jiwa Poris. Individual factors were used to choose samples, including those who had recently purchased and consumed Janji Jiwa items. For this study's primary data, 125 respondents were given questionnaires to complete. The information gathered for this study is cross sectional and is based on the time period. The Structural Equation Model (SEM) is the analytical technique used. Google forms were utilized to distribute the data. The simultaneous test method (F test) and the coefficient of determination test (R2) are used to test hypotheses. According to the study's findings, customer loyalty is significantly impacted by both customer value marketing and public relations.
Research Progress on Multiple Effects and Clinical Application of Proprotein Convertase Subtilisin-kexin9 Inhibitors
Authors: Feng Yan , Luo Weng-Ping , Zhang Ming-Ming , She Lin-Cong , Wang Jia-Xin , Sun Yong-Xin , Chen Chen , Zhang Wei
Published: April 2024

PCSK9 inhibitors (Proprotein convertase subtilisin-kexin9 inhibitors) not only have a good lipid-lowering effect but also have the effects of improving cardiovascular outcome, anti-inflammation, reducing oxidative stress and improving vascular endothelium. In recent years, the continuous research and development of PCSK9 inhibitors have provided new ideas for the treatment of cardiovascular diseases. This article reviews the multiple action mechanisms of PCSK9 inhibitors and their research in kidney disease and cerebrovascular diseases.
Analyzing Global Stability of M-Pox Disease Dynamics: Mathematical Insights into Detection and Treatment Strategies
Authors: Olopade Isaac A. , Akinwumi T. O. , Philemon M. E. , Mohammed I. T. , Sangoniyi S. O. , Adeniran G. A. , Ajao S. O. , Bello B. O. , Adesanya A. O.
Published: April 2024

In this research, a mathematical model is constructed to scrutinize the transmission patterns of monkeypox (mpox), with a specific emphasis on integrating the early detection of infected undetected individuals to curb its transmission. This research takes into account a range of factors influencing the propagation of monkeypox, encompassing population demographics, contact dynamics, and the efficacy of early detection of unidentified infected individuals. Employing the next-generation matrix method, the basic reproduction number (R0) is computed, revealing that the disease-free equilibrium state is locally asymptotically stable when (R0<1). This suggests that containment of monkeypox is achievable within a human populace where (R0)  remains below one (1), yet it transitions to an endemic state when (R0) exceeds this critical value one (1). Furthermore, a sensitivity analysis is conducted to evaluate the robustness of our findings to variations in model parameters. Utilizing numerical simulations conducted via MAPLE 18, we demonstrate the significance of prompt identification and immediate intervention for infected individuals who may otherwise go undetected, in effectively diminishing the dynamic propagation of monkeypox. The results underscore the pivotal role of early detection in mitigating monkeypox outbreaks and curtailing transmission rates.
Time Series Modelling and Forecasting Foreign Direct Investment using Linear and Nonlinear Models: The Case of Nigeria
Authors: Awariefe C. , Ogbereyivwe O.
Published: April 2024

This study addresses the crucial need for accurate forecasting of Foreign Direct Investment (FDIT) trends in Nigeria. FDIT plays a pivotal role in the country's economic growth and development efforts, driving industrialization, infrastructure enhancement, and job creation. However, predicting FDIT accurately is essential for policymakers, investors, and researchers to formulate effective strategies and decisions. This study conducts a comparative analysis of four FDIT forecasting models: Simple Exponential Smoothing (SES), Holt Exponential Smoothing (HES), ARIMA, and NNAR in Nigeria, utilizing R version 4.3.2 and forecast and nnetar packages for implementation. The FDIT dataset is partitioned into 80:20 training-test samples, with models applied to each subset for performance evaluation. Leveraging historical FDIT data, the study evaluates the predictive performance of each model over a specified period, employing error measures such as RMSE, MAE, MASE and MAPE to assess accuracy and reliability. Additionally, residual normality tests and visual inspections validate model assumptions. Results indicate varying levels of accuracy and predictive capability among the models, with HES and NNAR models displaying superior performance compared to SES and ARIMA, evidenced by measure error rates. Residual normality tests affirm the suitability of the models for FDIT forecasting. The study contributes empirical evidence to the existing literature, providing valuable insights into forecasting techniques for FDIT in Nigeria. These insights can guide policymakers, investors, and researchers in selecting appropriate models for forecasting FDIT trends and making informed decisions. Future research avenues could explore advanced modelling techniques and additional variables to further enhance the accuracy and reliability of FDIT forecasts within the Nigerian context.
Reconsidering Student Success in the Age of Artificial Intelligence
Authors: Hu Shouping , Ke Fengfeng
Published: April 2024

In this editorial by Dr. Shouping Hu and Dr. Fengfeng Ke at Florida State University, they discuss the need to systematically reconsider the nature of student success in the age of artificial intelligence.
Relaciones entre la matemática, el pensamiento algorítmico y el pensamiento computacional
Authors: Navas-López Eduardo Adam
Published: April 2024

En un mundo cada vez más influenciado por las herramientas computacionales disponibles y la aceleración en el desarrollo de estas, es necesario también incrementar la investigación epistemológica sobre las interacciones entre la matemática y las ciencias de la computación. Por ello se considera relevante estudiar las relaciones entre la habilidad de algoritmizar, el pensamiento matemático, el pensamiento algorítmico y el pensamiento computacional. Sin embargo, múltiples definiciones de pensamiento computacional no incorporan explícitamente al pensamiento algorítmico ni enfatizan su dimensión matemática. La proposición que se plantea en este ensayo científico es que existen relaciones, a veces implícitas, muy importantes entre los conceptos de algoritmización, pensamiento matemático, pensamiento algorítmico y pensamiento computacional. Y el objetivo es identificar las relaciones entre esos conceptos, y con ello fortalecer la literatura científica que busca abordarlos de forma integrada. Se concluye que el pensamiento algorítmico es una parte fundamental del pensamiento computacional, pero también es un tipo de pensamiento matemático; que la habilidad de algoritmizar es básica en la matemática y es fundamental en el pensamiento algorítmico y en el computacional, y que el pensamiento computacional brinda importantes ayudas en la exploración y descubrimiento de la matemática.
Long-term outcomes of COVID-19 infection in children and young people: a systematic review and meta-analysis
Authors: Twohig Helen , Bajpai Ram , Corp Nadia , Faux-Nightingale Alice , Mallen Christian , Robinson Toni , Somayajula Glenys , van-Der-Windt Danielle , Welsh Victoria , Burton Claire
Published: April 2024

Background Children and young people (CYP) may experience prolonged symptoms following COVID-19, commonly termed ‘Long-COVID’. The characteristics of Long-COVID in CYP are unclear, as are the sequalae of acute COVID-19. We aimed to systematically synthesise evidence of the long-term outcomes of COVID-19 in CYP. Methods 13 electronic databases were searched until January 2022. Inclusion criteria: observational studies reporting outcomes occurring four-weeks or more after COVID-19 in children <18 years old. Exclusion criteria: outcomes of Paediatric Inflammatory Multisystem Syndrome. Title, abstract and full text screening were conducted independently by two reviewers. Data extraction and risk of bias assessment was by one reviewer with independent verification. Critical appraisal tools appropriate for study type were employed. Results were narratively synthesised with meta-analysis to generate summary estimates of risk of prolonged symptoms in CYP. Results 94 studies were included in this systematic review. Of these, 66 studies recruited from hospital settings and 8 studies recruited solely from community settings. Over 100 symptoms were reported, the most common being fatigue, headache and cognitive symptoms. Summary estimates of prevalence of prolonged symptoms were higher for hospital samples (31.2%, 95% CI 20.3% to 43.2%) than for community samples (4.6%, 95% CI 3.4% to 5.8). Reported sequalae of COVID-19 in CYP included stroke, type-1 diabetes, Guillan-Barre syndrome, and persistent radiological or blood test abnormalities. Most studies reporting these sequalae were case reports / case series and the quality of evidence in these studies was low. Conclusions Prolonged symptoms following COVID-19 in children are variable and multi-systemic. Rates of prolonged symptoms in community samples are lower than hospital samples. There is currently limited good quality data on other sequalae in CYP. Heterogeneity in methods of diagnosis of COVID-19, symptom classification, assessment method and duration of follow-up made synthesis less secure.
The Effects of Admission Policies on Rates of Family Migration in European States, 2008–2019
Authors: Ahlén Anton
Published: April 2024

This study investigates whether and how much family migration policies have influenced patterns of family migration in European states. Family migration has been the largest category of entry in many Western countries in recent decades, and it has been the subject of increasing contestation in political debates. While research on family migration policies has advanced in recent years, no comprehensive cross-country comparisons have been done of the impact of different policies on the size and composition of family migrant inflows. This study addresses this gap by analysing the connection between admission policies and rates of family migration in 31 European states during the 2008 to 2019 period. Combining data from Eurostat and the Migrant Integration Policy Index (MIPEX), this study uses a time-series regression analysis to assess the effects of admission policies on different types of family related immigration. While restrictive admission policies have led to falling overall levels of family migration, the analysis here reveals stratifying implications, whereby the effect has been greater where the sponsor is a non-EU citizen than where he/she is an EU citizen. By providing evidence on the differential impacts of admission policies on family related immigration, this study contributes new insights on the effects of restrictive migration policies.
Baryonic Imprints on DM Halos: the concentration-mass relation and its dependence on halo and galaxy properties
Authors: Shao Mufan , Anbajagane Dhayaa
Published: April 2024

The halo concentration-mass relation has ubiquitous use in modeling the matter field for cosmological and astrophysical analyses, and including the imprints from galaxy formation physics is tantamount to its robust usage. Many analyses, however, probe the matter around halos selected by a given halo/galaxy property – rather than by halo mass – and the imprints under each selection choice can be different. We employ the CAMELS simulation suite to quantify the astrophysics and cosmology dependence of the concentration-mass relation, , when selected on five properties: (i) velocity dispersion, (ii) formation time, (iii) halo spin, (iv) stellar mass, and (v) gas mass. We construct simulation-informed nonlinear models for all properties as a function of halo mass, redshift, and six cosmological/astrophysical parameters, with a mass range . There are many mass-dependent imprints in all halo properties, with clear connections across different properties and non-linear couplings between the parameters. Finally, we extract the relation for subsamples of halos that have scattered above/below the mean property- relation for a chosen property. Selections on gas mass or stellar mass have a significant impact on the astrophysics/cosmology dependence of , while those on any of the other three properties have a significant (mild) impact on the cosmology (astrophysics) dependence. We show that ignoring such selection effects can lead to errors of ≈25% in baryon imprint modelling of . Our nonlinear model for all properties is made publicly available.
A Better Place to Be- Reclaiming History for Political Theory
Authors: Christopher R. Binetti
Published: April 2024

This paper analyzes the periodization of Western history, broadly construed. It first divides the Old World (Asia, Africa, and Europe) into three macro-civilizations (or Civilizations), that are further broken down into micro-civilizations, or civilizations. The West covers the modern Middle/Near East, North Africa, Europe, and Central Asia. The East covers East Asia, including Mongolia, as well as Singapore and Vietnam. The Central Civilization covers South Asia and the rest of Southeast Asia. After making this division, the paper then breaks down Western history into basic periods, specifically for the purposes of Political Theory. Western history is broken up into nine basic periods, which form four ages, three epochs, and two eons. Ancient time is divided from Medieval-Modern time into two eons. Ancient time is then broken up into seven periods, forming three ages and two epochs, the latter group corresponding to the Bronze/Iron Age dichotomy. This system is devised specifically for Political Theory, and to a lesser extent, the rest of Political Science, in order to avoid biased from looking backwards at history, specifically those that divide the Greater Mediterranean world (a.k.a. the West) by modern religion.
Dimensiones estratégicas de sostenibilidad y resiliencia en la cadena de suministro de la empresa Aptiv
Authors: Inzunza Mejía Patricia Carmina , Valenzuela-Valenzuela Oracio , Castro-Cuadras Dulce Livier , Cuevas López Carely Cecilia
Published: April 2024

Se analizan las dimensiones estratégicas de la cadena de suministro de la empresa Aptiv, como modelo de óptimo funcionamiento en la administración de inventarios y los flujos de suministro que la hacen resiliente y sostenible. Es de enfoque cualitativo, de tipo exploratorio y descriptivo, bajo un diseño no experimental. Se desarrolló el método analítico para la revisión de la literatura científica y el de estudio de caso, siguiendo los principios de just in time y de administración de inventarios. Se implementó el modelo de intervención de práctica profesional, las técnicas de entrevista semiestructurada y el cuestionario autoadministrado. En conclusión, las dimensiones social, ambiental, industria de calidad y tecnológica consolidan la cadena de suministro, haciéndola resiliente y sostenible, mediante la aplicación de estrategias que optimizan la gestión de inventarios con base en la tecnología, la experiencia y el aprendizaje reforzado de los procesos de suministro que permiten una distribución sencilla, amigable y resiliente, con acciones de cuidado y protección al medio ambiente, así como estrategias éticas y de responsabilidad social que fortalecen las gobernanzas y la relación con sus clientes asociados (Tier 2, Tier 3 y OEM); razón por la que la empresa no solo perfecciona de manera permanente su estrategia de sostenibilidad, sino que también da continuidad y seguimiento a las directrices de la Global Reporting Initiative (GRI) para mantener la aplicación de estándares de calidad; por lo que, desde la perspectiva de gobernanza, se someten a procesos de evaluación externa para visibilizar su impacto económico, tecnológico, social y ambiental.
Exploring the Success of Implementing Project-Based Learning Model in Accounting Learning Material
Authors: Andalusia Balqis , Suranto Suranto , Haque Farhat
Published: April 2024

This study aims to explore the success of implementing the Project Based Learning (PjBL) model in the elements of Service, Trade, and Manufacturing Company Accounting. The approach used in this research was qualitative with a case study method. This research selected one vocational school with high integrity, namely SMKN 1 Banyudono, with several informants consisting of students in Financial and Institutional Accounting classes, Accounting Teachers, and the School Principal. Data collection methods included interviews, observations, and documentation studies, with data validity tested through technique triangulation and source triangulation. The collected data was analyzed through three activities: data reduction, data presentation, and drawing conclusions or verification. The results showed that PjBL had a positive impact on students' learning outcomes, the quality of learning, and learning motivation. However, its weakness laid in requiring longer project implementation time and preparation. Nevertheless, PjBL can create an innovative learning environment, make graduates more prepared for the industrial world, and have a positive impact on students' learning outcomes and the quality of learning.
Development of Digital Teaching Materials for Short Story Texts with Critical Thinking Character for Junior High School Students
Authors: Supiah Supiah , Gloriani Yusida , Mascita Dede Endang
Published: April 2024

This research aims to develop digital teaching materials for short story texts containing critical-thinking characters for junior high school students. This study used the research and development method with the ADDIE model, which includes five research stages: design, development, implementation, and evaluation. The data used were the results of expert validation of teaching materials and the results of implementation of the use of teaching materials for students. The data collection technique used a questionnaire, which was then analyzed descriptively and qualitatively. As a result of the analysis of short story text materials based on structure and content containing critical character content, five short stories were selected, namely Jono dan Kepala Sekolah, Di Penghujung Minggu, Radio 109.1 FM, Permainan Takdir, and Kode Ujian. Based on the validation results, the structure of the teaching materials consists of Title, Foreword, Learning Instructions, and Learning Introduction; Learning activity 1 contains listening elements, learning activity 2 contains reading and viewing elements, learning activity 3 contains speaking and presenting elements, learning activity 4 contains writing elements. Summary, evaluation, reflection, glossary and bibliography. The results of the implementation of teaching materials in two schools, each school using three classes, were obtained: an average score of 81.2, which can be concluded that the digital teaching materials of short story texts containing critical thinking which were implemented for class IX students can be said to be very suitable for use in Indonesian language learning.
Innovation Capacity in the Management System of Islamic Boarding School Education Institutions : Quality Test of Instruments through Exploratory and Confirmatory Factor Analysis
Authors: Pratama Robin , Yaakob Mohd Faiz Mohd , Hendra Robi , Wulandari Okky
Published: April 2024

This study aims to test the validity and reliability of instruments measuring the variable of innovation capacity in the management system of Islamic boarding school education institutions in Jambi City. This research method employed a cross-sectional survey design with a quantitative approach. The sample size for this study consisted of 162 teachers (Ustad/Ustadzah) in Islamic boarding school education institutions. Quantitative data were analyzed using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) using SPSS 23 and AMOS 18. The results of this study indicated that EFA identified five factor structures to construct the dimensions of Innovation Capacity (IC), namely Opportunity Exploration (OE), Idea Sustainability (IS), Idea Introduction (II), Idea Emergence (IE), and Idea Realization (IR). Meanwhile, these findings were verified and confirmed by CFA regarding the factorial validity analysis of the Innovation Capacity dimension from the EFA testing results. This study suggests that future innovation capacity instruments require further adjustment to enhance the level of reliability and the ability to explain differences related to the measured constructs within different contexts, cultures, and conditions.
Multidisciplinary management of muscle-invasive bladder cancer
Authors:   , Voskuilen Charlotte Sophie
Published: April 2024

Muscle-invasive bladder cancer is an aggressive disease with high risk of progression or death if left untreated. Unlike many other cancers, there has been no significant improvement in survival rates for bladder cancer for three decades. To improve survival and quality of life, a multidisciplinary approach is essential. In this thesis, several aspects of the multidisciplinary management of muscle-invasive bladder cancer were studied, with a focus on neoadjuvant chemotherapy, staging by FDG-PET/CT, and organ-preserving therapies.
Measuring interactions between colloidal (nano)particles
Authors:   , Bransen Maarten
Published: April 2024

Colloidal dispersions, which are liquids with finely dispersed particles of between 1 nanometer and 10 micrometer in size, are ubiquitous in nature and in man-made applications. The stability of colloidal particles and the processes underlying their assembly into functional materials are governed by the interaction forces between the particles, and knowledge of these interaction forces is thus crucial to understand and predict their properties. In this thesis we explore methods to measure these interaction forces experimentally, with a focus on measurements of nanoparticles because their interactions are particularly difficult to predict using theory. We first review the different techniques which have been used to perform such measurements and their relevance to nanoparticles, and subsequently study two conceptually different methods by which interaction forces may be extracted from real-space microscopy data. This is done firstly through the analysis of equilibrium distribution functions which may be obtained from a single snap-shot of the particle positions. We demonstrate such measurements for a number of different (nano)particle systems using different 3D optical and electron micron microscopy techniques. Finally, we demonstrate using simulations and experiments that for micron-sized colloids interaction forces may be extracted without relying on equilibrium conditions through measurement of the particle dynamics using high-speed 2D and 3D optical microscopy, and extend this method to allow for measurement of particles with anisotropic (dipolar) interaction forces out of equilibrium.
Between Melpomene and Thalia
Authors:   , Haaker Maya Wilhelmina
Published: April 2024

The liver plays an important role in processing (nutritional) substances that enter our body through the intestines. This includes breakdown of alcohol and many forms of medication. The liver also handles the storage or onward transport of sugars, fats and vitamin A. In the Western world, alcohol and a diet with excessive fat, sugar and cholesterol are increasingly part of the causes of liver disease in humans. Initially, fat will accumulate in the liver, but can cause liver damage at later stages. Repeated damage leads to excessive formation of extracellular matrix, the development of liver fibrosis and ultimately liver cirrhosis. As a result, liver function is hampered with increased chances for liver cancer. The main producers of the extracellular matrix proteins are activated hepatic stellate cells (HSCs). This cell type can behave in very different ways. Liver damage leads to various stages of activation and extracellular matrix production, but in a healthy liver the HSCs are quiescent and serve as the main storage site for vitamin A in the body.
This thesis investigates how factors from the cellular environment (matrix and presence of hepatic progenitor cells) can be of influence to the activation stage of HSCs with particular emphasis on changes in vitamin A and lipid metabolism. We show that, by making use of a different matrix, HSCs can be kept quiescent in cell culture and used for research of vitamin A metabolism in quiescent HSCs. At the same time, we show unexpected retinyl ester (the storage form of vitamin A) synthesis during early activation. Co-culture of HSCs and progenitor cells in a 3D organoid system shows that these cell types can directly interact with each other, mimicking cellular responses seen during ductular reaction. Many different lipids exist, and in this thesis we show how influencing the metabolism of specific lipids influences the communication, functioning and survival of the HSC. If we can let HSCs wear their quiescent, happy mask (Thalia) this will help animal and human liver patients prevent tragedy (Melpomene).
Modelling the nonlinear system performance of hybrid-electric propulsion systems with aerothermodynamic interdependencies
Authors: Goeing Jan , Hanisch Lucas , Lück Sebastian , Henke Markus , Friedrichs Jens
Published: April 2024

The development of commercial aircraft with hybrid-electric propulsion systems is currently a subject of extensive research in order to improve local air quality and reduce combustion emissions. Among the various types of engines being studied, the two-spool parallel hybrid-electric turbofan engine is particularly challenging due to the low-pressure compressor (LPC). The hybridisation process tends to throttle the LPC, accentuating its significance in the propulsion system. For reliable operation of such systems, accurate predictions of the LPC performance during time-sensitive manoeuvres such as a go-around are important. These manoeuvres are heavily influenced by time-dependent effects that govern the propulsion system’s performance. Often, the aerothermodynamic interplay between these effects is overlooked in propulsion models.

In this study, the influence of these aerothermodynamic interdependencies on the modelling results is investigated. To investigate these aerothermodynamic interactions, a dynamic model is developed to simulate the performance of the hybrid-electric turbofan engine. In comparison, a constant mass flow model is used, which is not able to simulate these interdependencies.

The results show that the aerothermodynamic interdependencies significantly affect the modelled time-resolved performance, especially for surge margin of the LPC, with this effect becoming more pronounced at higher levels of hybridisation. Therefore, the study recommends the adoption of dynamic simulation methodologies for hybrid-electric engines to guarantee high simulation precision, enhance reliability, and satisfy safety standards.
Intervención social dirigida al envejecimiento saludable: revisión de estudios recientes
Authors: Borrego Ruiz Alejandro , Bustillos López Antonio
Published: April 2024

En los últimos años se ha producido una inversión demográfica caracterizada por un marcado incremento de las personas mayores de 65 años. Este hecho plantea retos sociales, sanitarios, culturales y económicos, que destacan la necesidad de aplicar estrategias dirigidas a mejorar las condiciones de envejecimiento entre la población. El objetivo del presente trabajo fue realizar una revisión de las intervenciones encuadradas en el marco del envejecimiento saludable mediante la evaluación de una serie de estudios que abordan el tema en cuestión. Para ello, se llevó a cabo una búsqueda bibliográfica resultante en la selección de diez artículos publicados durante la última década, que fueron analizados en función de sus elementos descriptivos y metodológicos, del cálculo de su potencia estadística post hoc y del grado de cumplimiento de los siguientes indicadores de calidad: relevancia, adecuación, innovación, aplicabilidad, transferibilidad, igualdad y ética. Se concluye que, de acuerdo con las debilidades encontradas en los estudios analizados, se requiere una mayor investigación en el diseño, en la implementación y en la evaluación de los programas destinados a promover el envejecimiento saludable.
Personas mayores y soledad: conocer para intervenir
Authors: Vélez Mercedes , Cáceres Christian , Menéndez Susana
Published: April 2024

La soledad es un fenómeno complejo que en los últimos años ha ido adquiriendo mayor relevancia a nivel social y académico. Esta nueva y creciente realidad social plantea retos a diferentes niveles (sanitario, laboral, legal, administrativo, etc.) y constituye un importante desafío para la administración. Las relaciones sociales de calidad destacan como estrategia para reducir la soledad y el aislamiento social, y forman parte de las propuestas de la OMS para la promoción del envejecimiento activo y saludable. Para afrontar este desafío es necesario conocer qué es la soledad y qué impacto tiene en la salud, qué características suelen tener las personas que la experimentan y cuáles son las posibilidades de intervención. El propósito de este trabajo es revisar y resumir la literatura científica reciente sobre estas cuestiones, con especial referencia al contexto español.
Aislamiento e identificación del fitopatógeno causal de viruela o “negrilla”en Agave salmiana de municipios del estado de Hidalgo, México
Authors: Hernández José Jessica , Hernández Domínguez Edna María , López Vázquez Erick , Álvarez Cervantes Jorge
Published: April 2024

Antecedentes: La viruela o negrilla es una enfermedad presente en las hojas de Agave spp, manifestándose con manchas foliares de color negro parecido al hollín. Se ha reportado que el daño es causado por Asterina mexicana, sin embargo, se desconoce si es el único hongo que causa dicha enfermedad.
Objetivo: Identificar por métodos microbiológicos y moleculares el agente causal de viruela o negrilla en plantas de Agave salmiana de diferentes municipios del estado de Hidalgo, México.
Métodos: Se utilizaron métodos microbiológicos y moleculares para la identificación de hongos causantes de viruela o negrilla en plantas de Agave salmiana.
Resultados y conclusiones: Dentro del análisis, las cepas que se aislaron de las lesiones en hojas de A. salmiana mostraron características macroscópicas y microscópicas correspondientes al género Curvularia y la identificación molecular comprobó la presencia de Curvularia lunata. De lo anterior se deduce que la enfermedad de viruela o negrilla presente en A. salmiana no necesariamente puede ser causada por A. mexicana, siendo el primer reporte donde se aísla C. lunata de un hospedero atípico como agave.
Antioxidant activity of the aqueous extract from spent coffee grounds fermented with Pleurotus ostreatus
Authors: Vargas Sánchez Rey David , Esqueda Martín , Torres Martínez Brisa del Mar , Torrescano Urrutia Gastón Ramón , Sánchez Escalante Armida
Published: April 2024

Background: Coffee residues, including spent coffee grounds (SCG), are an important source of bioactive components like phenolic compounds which are characterized to exert bioactivity.
Objective: Evaluate the antioxidant effect of the aqueous extract obtained from SCG, under submerged-state fermentation using Pleurotus ostreatus.
Methods: Submerged-state fermentation using Pleurotus ostreatus was used to release phenolic compounds from SCG (0, 5 and 10 %). After fermentation, the qualitative and quantitative phytochemical content was monitored (carbohydrates, polyphenols, flavonoids, and cafeoylquinic acid), as well as the antioxidant properties (antiradical activity and reducing power). In addition, lipid oxidation levels of pork meat homogenates incorporated with SCG extract during storage were evaluated.
Results and conclusions: The results showed an increase in phytochemical content and antioxidant properties in the aqueous extract from SCG fermented with P. ostreatus, in dependence of the used substrate concentration. Also, a reduction in lipid oxidation values was showed in pork meat homogenates treated with the fermented SCG extract. Fungal fermentation process of coffee residues using Pleurotus spp., could be a promissory strategy to obtain natural additives.
Emerging roles of hydrogel in promoting periodontal tissue regeneration and repairing bone defect
Authors: Guo Wendi , Dong Hongbin , Wang Xing
Published: April 2024

Periodontal disease is the most common type of oral disease. Periodontal bone defect is the clinical outcome of advanced periodontal disease, which seriously affects the quality of life of patients. Promoting periodontal tissue regeneration and repairing periodontal bone defects is the ultimate treatment goal for periodontal disease, but the means and methods are very limited. Hydrogels are a class of highly hydrophilic polymer networks, and their good biocompatibility has made them a popular research material in the field of oral medicine in recent years. This paper reviews the current mainstream types and characteristics of hydrogels, and summarizes the relevant basic research on hydrogels in promoting periodontal tissue regeneration and bone defect repair in recent years. The possible mechanisms of action and efficacy evaluation are discussed in depth, and the application prospects are also discussed.
A decision support system for upper limb rehabilitation robot based on hybrid reasoning with RBR and CBR
Authors: Li Sujiao , Xiang Shuhan , Ma Qiqi , Cai Wenqian , Liu Suiyi , Fang Fanfu , Yu Hongliu
Published: April 2024

The rehabilitation robot can assist hemiplegic patients to complete the training program effectively, but it only focuses on helping the patient’s training process and requires the rehabilitation therapists to manually adjust the training parameters according to the patient’s condition. Therefore, there is an urgent need for intelligent training prescription research of rehabilitation robots to promote the clinical applications. This study proposed a decision support system for the training of upper limb rehabilitation robot based on hybrid reasoning with rule-based reasoning (RBR) and case-based reasoning (CBR). The expert knowledge base of this system is established base on 10 professional rehabilitation therapists from three different rehabilitation departments in Shanghai who are enriched with experiences in using desktop-based upper limb rehabilitation robot. The rule-based reasoning is chosen to construct the cycle plan inference model, which develops a 21-day training plan for the patients. The case base consists of historical case data from 54 stroke patients who underwent rehabilitation training with a desktop-based upper limb rehabilitation robot. The case-based reasoning, combined with a Random Forest optimized algorithm, was constructed to adjust the training parameters for the patients in real-time. The system recommended a rehabilitation training program with an average accuracy of 91.5%, an average AUC value of 0.924, an average recall rate of 88.7%, and an average F1 score of 90.1%. The application of this system in rehabilitation robot would be useful for therapists.
Investigation on the behaviors of water infiltration in the unsaturated loess
Authors: Xi Yu , Hua Xue-Qing , Li Gang , Wang Peng-Zhou , Yang Sha-Sha
Published: April 2024

Introduction: Surface water from precipitation or irrigation is the sole contributor to groundwater replenishment in the Loess Plateau of China. The occurrence of landslides in the Loess Plateau is closely related to the infiltration process of surface water, and the frequent occurrence of landslides in the Loess Plateau in recent years has seriously affected the economic development and security of the Loess Plateau.

Methods: To investigate the loess infiltration in deeper soil, the process of moisture infiltration in unsaturated loess is studied by field observation, theoretical analysis, and numerical simulation.

Results and discussion: The research results indicated that the interstitial flow in loess could be divided into three different zones: the active zone, the stable zone (2–94 m), and the saturated zone (below 97 m); based on the matric suction and water content calculations, the L1 soil stable water content is 24.4%, which corresponds to the moisture sensor measurement of L1 loess 4 m and 7 m of stable zone data; the numerical simulation results show that whether the infiltration is continuous or intermittent, the infiltration law is the same. After 20 years, there will be a stable water content zone in the 1–8 m soil layer with a water content of 31%. The numerical results well confirm the theoretical calculation results. The research results explain the process of surface water infiltration into groundwater through thick loess and can provide an important reference for the prevention and control of geological disasters caused by water infiltration in loess areas.