bluuebunny/crossref_metadata_2025 huggingface dataset:
Design of a Panoramic Virtual Dynamic Display System for Digital Museums Based on Visual Interaction Technology
Authors: Wang Jing
Published: April 2022

To address the spatial and temporal limitations of historical museums, a panoramic virtual dynamic display system for digital museums is designed using visual interactive technology. The VM file is generated by using the Digital Museum Design module to obtain a list of available objects, and the VM file is analysed by the Digital Museum View module to stretch and change the two-dimensional flat map into a three-dimensional spatial map for viewers to browse. The system software designs the technical construction process of the digital museum, uses a linearisation algorithm to calculate the number of clicks, visualises the font according to the number of clicks reflecting the weights, and builds a tag cloud component to provide interactive services to facilitate efficient understanding of the museum information by the viewer.
Research on Virtual Human Motion Control Based on Computer-Assisted Multimedia Simulation
Authors: He Xiangzi , Jin Xinqin , Zheng Jun
Published: April 2022

In order to reproduce realistic human motion in a virtual environment, a study of virtual human motion control based on computer-aided ergonomics simulation is proposed. First, we establish the required human body, workpiece, and production line simulation environment, and on this basis, we use OWAS, BSHA, and other analysis tools to carry out ergonomic simulation of virtual human motion simulation research, seek solutions to man-machine problems, and provide a new, efficient, and quantitative evaluation method for production line planning. The simulation results show that during the operation of virtual human 1, the ratio of the actual load on the left and right hands to the ultimate load has reached up to 70%. Therefore, it is necessary to revise the production line plan, and through analysis, it is concluded that the reason for the bad posture is due to the low height of the storage point and the machine tool. We believe that with continuous development, ProcessSimulate and ProcessDesigner will play a greater role in enterprise digitization.
Synthesis, Characterization, and Evaluation of the Remediation Activity of Cissus quadrangularis Zinc Oxide Nanoparticle-Activated Carbon Composite on Dieldrin in Aqueous Solution
Authors: Ondijo Calvince , Kengara Fredrick , K’Owino Isaac
Published: April 2022

In this study, zinc oxide-activated carbon nanocomposite was used as the adsorbent for the remediation of dieldrin in aqueous media. Zinc oxide nanoparticles (ZNPs) were synthesized from Cissus quadrangularis (C. quadrangularis) leaf extract, and activated carbon was derived from maize cobs. Nanocomposites were formulated by mixing the ZNPs with the activated carbon in a ratio of 1 : 50. The UV-Vis spectra showed a complete reduction of Zn2+ to Zn0 with plasmon resonance bands in the range of 361–376 nm, which is a characteristic of ZNPs. The SEM images of ZNPs showed hexagonal-shaped particles of 15–20 nm, with face-centered cubic crystals, as demonstrated by XRD analysis. FTIR results showed absorption bands in the ranges 3500–3100 cm−1 (N-H stretch), 3400–2400 cm−1 (O-H stretch), 988–830 cm−1 (C-H bend), 1612 cm−1 (C=C stretch), 400–600 cm−1 (Zn-O stretch), and 1271 cm−1 (C-O bend). Batch adsorption experiments were performed using 20 ml of dieldrin solution at varying pH values (1–14), concentrations (5–100 ppm), temperatures (293–323 K), adsorbent dosages (0.01–0.12 g), and contact times (30–180 minutes) to determine the optimum conditions. The calculated thermodynamic parameters (ΔH°, ΔS°, and ΔG°) indicated that the adsorption was spontaneous and exothermic in nature, implying decreasing randomness of dieldrin molecules at the solid-liquid interface. The isotherm and adsorption kinetics for the composite showed that the absorption process followed Langmuir isotherm and pseudo-second-order kinetics. Adsorption capacities of the nanoparticles, activated carbon, and nanocomposite at a reaction time of 120 minutes and pH of 7 were 3.72 ± 0.068 mg/g, 3.92 ± 0.061 mg/g, and 4.0 ± 0.102 mg/g, respectively, with corresponding percentage removals of 93.12 ± 0.044, 98.04 ± 0.044, and 99.76 ± 0.332. Thus, the nanocomposite exhibited a better sorbing potential for dieldrin in solution than activated carbon. This study recommends testing the remediation potential of the synthesized nanocomposite on other persistent organic pollutants.
Percutaneous Closure of Patent Foramen Ovale after Anterior Spinal Cord Infarction
Authors: Reis João Ferreira , Loureiro Petra , Silva Rita Lopes , Martins José Diogo
Published: April 2022

In patients with a patent foramen ovale (PFO) who have had a cryptogenic ischemic stroke, percutaneous closure reduces its recurrence risk. However, its role in spinal cord infarction (SCI) is less well-established. A few case reports describe the putative causative role of PFO in SCI. We present a case of a teenager with cryptogenic anterior SCI in the setting of a deep vein thrombosis and a high risk-PFO who underwent successful percutaneous closure.
Study on Influence of Adhesion Properties in Screen Printing Electronic Ink Transfer
Authors: Tian Ye , Yuan YingCai , Zhao Lin , He GaoSheng , Peng TuoKai , Xu Jianlin , Cao LiJie , Gu TianQi , Li Yan
Published: April 2022

Printing electronic components by screen printing with the excellent printing quality, high efficiency, and environmental protection has broad application prospects in additive manufacturing. However, because conductive-ink blocks the screen, printing efficiency and quality decreased in the printing process. Thus, it is pivotal to explore adhesion factors from the interaction of conductive ink and screen. Herein, according to the transfer process of screen printing ink, solid-liquid wetting theory, and adhesion mechanism, we establish a liquid bridge adhesion model between two plates and obtain the functional relationship between the adhesion force and its influencing factors. Fluent software verifies the adhesion force model's conclusion to get the influence trend of the adhesion force on the ink residue. At last, by establishing a liquid bridge tensile fracture test, we gain experimental results consistent with the theoretical model and numerical simulation results. It is demonstrated that solid-liquid contact angle, tensile distance, and liquid volume are the main factors affecting the change of solid-liquid adhesion. The increase of tensile distance and contact angle will affect the adhesion force. The smaller the maximum solid-liquid adhesion during the initial stretching of the liquid bridge, the less the residual amount remained on the solid surface. By means of screen modification, the adhesion between conductive ink and screen can be reduced; meanwhile, the efficiency and quality of printed products can be improved. What's more, it also provides a valuable reference for the modification of screen printing electronics.
TransEffiDet: Aircraft Detection and Classification in Aerial Images Based on EfficientDet and Transformer
Authors: Wang Yanfeng , Wang Tao , Zhou Xin , Cai Weiwei , Liu Runmin , Huang Meigen , Jing Tian , Lin Mu , He Hua , Wang Weiping , Zhu Yifan
Published: April 2022

In recent years, analysis and optimization algorithm based on image data is a research hotspot. Aircraft detection based on aerial images can provide data support for accurately attacking military targets. Although many efforts have been devoted, it is still challenging due to the poor environment, the vastness of the sky background, and so on. This paper proposes an aircraft detection method named TransEffiDet in aerial images based on the EfficientDet method and Transformer module. We improved the EfficientDet algorithm by combining it with the Transformer which models the long-range dependency for the feature maps. Specifically, we first employ EfficientDet as the backbone network, which can efficiently fuse the different scale feature maps. Then, deformable Transformer is used to analyze the long-range correlation for global feature extraction. Furthermore, we designed a fusion module to fuse the long-range and short-range features extracted by EfficientDet and deformable Transformer, respectively. Finally, object class is produced by feeding the feature map to the class prediction net and the bounding box predictions are generated by feeding these fused features to the box prediction net. The mean Average Precision (mAP) is 86.6%, which outperforms the EfficientDet by 5.8%. The experiment shows that TransEffiDet is more robust than other methods. Additionally, we have established a public aerial dataset for aircraft detection, which will be released along with this paper.
Experimental Studies on the Performance of Graphene Oxide Based Hybrid Nanopolymers for Bearing Applications
Authors: Rajamani Geetha , Mohankumar Madhan , Dhamodaran Gopinath , Prakash S. Om , Johnson Santhosh A.
Published: April 2022

In this experimental study, graphene oxide-blended glass-filled nylon (GO-GFN) hybrid nanopolymer composites were developed and characterized. Transmission electron microscopic studies were performed to study the dispersion of graphene oxide in glass-filled nylon composites. Dynamic mechanical analysis and thermogravimetric analyses were conducted on the fabricated hybrid nanopolymer composites to analyze the mechanical and thermal stability. Mechanical properties were investigated by tensile test. The test showed improvements in young’s modulus and tensile strength. Water absorption test was conducted to study the water absorption resistance of the hybrid nanopolymer composites. Finally, roller bearings with graphene oxide and glass-filled nylon were fabricated and analyzed for wear under varying load and speed conditions in the test rig developed in-house. The tests proved the suitability of deploying hybrid nanopolymer composites for bearing applications.
Stress-Relieving Video Game and Its Effects: A POMS Case Study
Authors: Ajmal Abdullah , Aldabbas Hamza , Amin Rashid , Ibrar Sundas , Alouffi Bader , Gheisari Mehdi
Published: April 2022

Stress is the response or a change in our bodies to environmental factors like challenges or demands that are physical and emotional. The main cause of stress is illnesses and it is gaining more interest, a hot topic for many researchers. Stress can be brought about by a wide range of normal life occasions that are hard to avoid. Stress generally refers to two things: first, the psychological perception of pressure and the body’s response to it. On the other hand, it involves multiple systems, from metabolism to muscles to memory. Many methods and tools are being developed to reduce stress in humans. Stress can be a short-term issue or a long-term problem, depending on what changes in your life. The emphasis of this article is to reduce the effects of stress by developing a stress-releasing game and verifying its results through the Profile of Mood States (POMS) and POMS-2 survey. Games are associated with stress levels; hence, parameters like sounds, visuals, and colors associated with reducing stress are used to develop a game for the stress reduction in the players. The survey research aims to determine that the purpose-built game will affect the player's stress level using a reliable psychological survey paper. The survey collected a variety of information from its participants over six months. Different aspects of a person’s psychology and reactions are recorded in this scenario by calculating the mean, standard deviation, degree of freedom, zero-error, and probability-value%. The POMS and POMS-2 results are obtained from the custom-built game, and these are found to be effective in reducing stress.
Effects of Pro/Prebiotics Alone over Pro/Prebiotics Combined with Conventional Antibiotic Therapy to Treat Bacterial Vaginosis: A Systematic Review
Authors: Afifirad Roghayeh , Darb Emamie Amir , Golmoradi Zadeh Rezvan , Asadollahi Parisa , Ghanavati Roya , Darbandi Atieh
Published: April 2022

Background. Bacterial vaginosis (BV), caused by an imbalance in the vaginal microbiota, can be treated and prevented by probiotics. Pregnant women with BV can experience premature labor and spontaneous abortions. Probiotics and prebiotics promote the proliferation of beneficial microorganisms, alter the composition of the vaginal microbiota, and prevent intravaginal infections in postmenopausal women. In addition to reducing infection symptoms, pre/probiotics can also help prevent vaginal infections. Materials and Methods. A systematic review was conducted on studies from 2010 to 2020 to determine the efficacy of pre/probiotics on the treatment of BV in pregnant and nonpregnant women. The databases Medline, Scopus, Embase, and Google Scholar were systematically searched using the following keywords: “bacterial vaginosis,” “probiotics,” “prebiotics,” and “synbiotics.” Results. A total of 1,871 articles were found in the initial search, and 24 clinical trials were considered eligible. In studies comparing the effects of pre/probiotics and placebos with or without antibiotic therapy in patients with BV, significant differences in clinical outcomes were observed. Probiotics reduced the levels of IL-1β and IL-6, as well as the overall Nugent score and Amsel’s criteria for restitution of a balanced vaginal microbiota. In addition, probiotics can reduce the vaginal colonization of Group B streptococci among pregnant women. In subjects treated with probiotics, BV cure rates were higher than those in subjects treated with antibiotics. There were no additional adverse events. Conclusion. Pre/probiotic regimens, when used for BV treatment, are usually safe and can exhibit long-term and short-term benefits. In order to prove the benefits of pre/probiotics in BV treatment, additional high-quality research is required.
An Efficient and Secure Data Sharing Method Using Asymmetric Pairing with Shorter Ciphertext to Enable Rapid Learning in Healthcare
Authors: Yadav Snehlata , Tiwari Namita
Published: April 2022

The recent advent of cloud computing provides a flexible way to effectively share data among multiple users. Cloud computing and cryptographic primitives are changing the way of healthcare unprecedentedly by providing real-time data sharing cost-effectively. Sharing various data items from different users to multiple sets of legitimate subscribers in the cloud environment is a challenging issue. The online electronic healthcare system requires multiple data items to be shared by different users for various purposes. In the present scenario, COVID-19 data is sensitive and must be encrypted to ensure data privacy. Secure sharing of such information is crucial. The standard broadcast encryption system is inefficient for this purpose. Multichannel broadcast encryption is a mechanism that enables secure sharing of different messages to different set of users efficiently. We propose an efficient and secure data sharing method with shorter ciphertext in public key setting using asymmetric (Type-III) pairings. The Type-III setting is the most efficient form among all pairing types regarding operations required and security. The semantic security of this method is proven under decisional BDHE complexity assumption without random oracle model.
GAP-43 Induces the Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells into Retinal Ganglial-Like Cells
Authors: Wang Xiaoke , Ma Chi , Nie Lili
Published: April 2022

Optic neuritis (ON) is a common neurological disease, and the transplant of retinal ganglion cells (RGCs) has been thought as a promising strategy for improving the injury of the optic nerve system. Bone mesenchymal stem cells (BMSCs) have the potential to differentiate into neural cells. Several studies have indicated that GAP-43 is related with the regeneration of nerve cells, while the effect of GAP-43 on inducing BMSC differentiation remains unclear. In this study, the BMSCs were separated from the rats and identified with flow cytometry assay. The GAP-43 expressed vectors were transfected into the BMSCs, and the biomarkers of RGCs such as PAX6, LHX2, and ATOH7 were used to observe by qRT-PCR. Moreover, the effect of GAP-43-induced BMSCs (G-BMSCs) on ON improvement was also verified with rat models, and the activity of MAPK pathway was measured with western blot. Here, it was found that GAP-43 could obviously promote the differentiation of BMSCs, and increased PAX6, LHX2, ATOH7, BRN3A, and BRN3B were observed in the process of cell differentiation. Moreover, it was also found that G-BMSCs significantly increased the abundances of NFL and NFM in G-BMSCs, and GAP-43 could also enhance the activity of MAPK pathways in BMSCs. Therefore, this study suggested that GAP-43 could induce the differentiation of bone marrow-derived mesenchymal stem cells into retinal ganglial cells.
A Secure Downlink Transmission Scheme for a UAV-Assisted Edge Network
Authors: Gao Xinmei , Huo Yan , Gao Qinghe , Zhao Hongjun , Ma Long
Published: April 2022

As an extension of centralized cloud services in a space-air-ground integrated network, an unmanned aerial vehicle (UAV-)-enabled edge network brings computation as close ground terminals of need as possible. In this scenario, the UAV is considered a mobile base station (MBS) to achieve data forwarding and processing from cloud servers to terminals. Note that downlink signals from the MBS to ground terminals are vulnerable to passive wiretapping by a malicious node. We formulate an average secrecy rate maximization problem to tackle the wiretapping issue by simultaneously transmitting confidential information and artificial noise (AN). We decompose the problem into two subproblems, including the UAV transmit power allocation subproblem and the UAV trajectory subproblem. Then, we adopt the successive convex approximation scheme and the alternating optimization method to develop our iterative algorithm to achieve secure transmission. Simulation results demonstrate that the proposed scheme is significantly better than other benchmarks in UAV-enabled downlink communication secrecy performance.
Research on the Influence of Voluntary Service Activities Participation on University Students’ Mental Health and Social Development
Authors: Jing Lixian , Wu Shangzhuo , Yu Shan , Zhao Shuguo
Published: April 2022

In light of the positive correlation between university students’ mental health and their social development, the research combined both social development and student participation theories with the correlation and linear regression analysis to explore the influence of voluntary service activities on university students’ mental health and social development. The results show that there are differences in students’ participation in voluntary activities in different grades, cadre experience, and academic achievement. All dimensions of university students’ participation in voluntary service activities have a significant positive influence on university students’ mental health and social development. The degree of participation, investment, interaction with other members, and achievement of expected objectives in university students’ voluntary service activities have different degrees of influence on university students’ ideological and moral cognition, personality development traits, and social adaptability.
Fucoxanthin, a Marine Carotenoid, Suppresses Mycoplasma pneumoniae-Triggered Inflammatory Cytokine Production and Promotes Bacterial Clearance in a Murine Model
Authors: Wu Hongbo , Li Shu , Wang Linlin , Liang Jun , Yan Lei , Dong Jianjiang
Published: April 2022

Mycoplasma pneumoniae (MP), an atypical bacterium, is a common pathogenetic organism of respiratory infection in children. In the present study, we analyzed the beneficial role of fucoxanthin (Fx), a marine carotenoid, in a murine model of MP. C57BL/6 mice were inoculated once intranasally with 107 CFU of M. pneumoniae, and we found that Fx treatment markedly decreased BAL (quantitative bronchoalveolar lavage) M. pneumoniae concentrations and alleviated airway obstruction in the infected mice. Moreover, the concentrations of proinflammatory cytokines, including IL-6, TNF-α and IL-1β, were significantly decreased by Fx treatment in the BAL samples of infected mice. In vitro study further indicated that Fx treatment markedly suppressed the production of proinflammatory cytokines in mouse peritoneal macrophages after M. pneumoniae infection. In conclusion, this may be the first study to report the protective role of Fx against M. pneumoniae infection, providing a potential therapeutic agent for MP.
Knowledge Discovery-Based Analysis of Health Factors of Urinary Infections in Elderly Cardiology Inpatients
Authors: Zhao Min , Pi Yan , Zhang Longbo
Published: April 2022

A set of semantic similarity calculation methods combining full-text text and domain knowledge topics is proposed for the current study of entity association relations such as disease–gene in medical texts combined with topics in knowledge discovery, which is insufficient to reveal the deep semantic association relations of medical domain knowledge at topic level. Taking urinary infections in elderly inpatients as the research subject, word embedding representation of word vectors and topic vectors is performed by the TWE model, and similarity calculation is performed by combining text and domain knowledge topics based on Siamese Network framework. The urinary microbiological culture results of both groups were dominated by Escherichia coli, accounting for 34.65% and 47.92%, respectively; the use of antimicrobial drugs in the symptomatic urinary infection group was 94.19% higher than that in the asymptomatic bacteriuria group, 77.27% (

x

2

 = 8.158,

P
=
0.004

).
Design and Optimization of Urinary Real-Time Nursing Model Based on Medical Internet of Things
Authors: Hao Wei , Hao Xiujun , Yang Chao
Published: April 2022

The medical Internet of Things (IoTs) can bind intelligent sensing devices with urinary nursing recipients and integrate information into various hospital information systems through network communication, so as to realize the intelligent perception, data collection, remote monitoring, information sharing, and other functions of urinary real-time nursing recipients. The urinary real-time nursing model can complete the expansion of hospital information system data to the bedside and the instant exchange of terminal data with the system through the medical IoTs and wireless local area network. Based on the summary and analysis of previous research results, this paper expounds on the research status and significance of the urinary real-time nursing model, elaborates on the development background, current status, and future challenges of medical IoTs, introduces the methods and principles of medical IoTs level evaluation system and transformation rules-based optimization algorithm, conducts urinary real-time nursing model design based on medical IoTs, analyzes model hardware design based on medical IoTs, performs model software design based on medical IoTs, proposes the urinary real-time nursing model optimization based on medical IoTs, explores the front-end function optimization of the urinary real-time nursing, implements the system program optimization of the urinary real-time nursing, discusses the hierarchical architecture of the urinary real-time nursing model, and finally carries out the role function analysis of the medical IoTs in the urinary real-time nursing model. The study results show that the urinary real-time nursing model based on medical IoTs can accurately and efficiently identify, manage, and integrate clinical nursing procedures and data such as patients, diagnoses, drugs, and can optimize nursing workflow, strengthen quality control, and improve nursing efficiency and provide patients with more convenient nursing services. The research results of this paper provide a reference for further research on the design and optimization of urinary real-time nursing model based on medical IoTs.
Development and Validation of a Liquid Chromatography-Mass Spectrometry Assay for Determination of Cromolyn Sodium in Skin Permeation Studies
Authors: Holman Miranda Kay , Brown Stacy D , Frempong Dorcas , Puri Ashana , Dinh Steven
Published: April 2022

Cromolyn sodium (CS) is a mast cell stabilizer administered to treat allergic diseases. A topical system would sustain its delivery and may be designed for treatment of atopic dermatitis. Established HPLC protocols for detection of CS are time consuming and intensive, indicating the need for a more streamlined method. This study aimed at developing and validating a sensitive and selective LC-MS method for quantifying CS in skin permeation studies that was less time and resource demanding. The optimized method involved an isocratic mobile phase (10 mM NH4HCO3, pH 8.0, 90% and ACN, 10%) at a flow rate of 0.25 mL/min. Detection involved direct MS/MS channels with m/z 467.0255 (precursor) and m/z 379.0517 (fragment) using argon as the collision gas. CS calibrants were prepared in PBS, pH 7.4, and methanol for validation (0.1–2.5 μg/mL). To ensure no skin interference, dermatomed porcine skin was mounted on Franz diffusion cells that were analyzed after 24 h. The skin layers were also separated, extracted in methanol, and analyzed using the developed method. Retention time was 1.9 min and 4.1 min in methanol and buffer, respectively. No interfering peaks were observed from the receptor and skin extracts, and linearity was established between 0.1 and 2.5 μg/mL. Interday and intraday accuracy and precision were within the acceptable limit of ±20% at the LLOQ and ±15% at other concentrations. Overall, the simplified, validated method showed sensitivity in detecting CS in skin without interference and was applied to demonstrate quantification of drug in skin following 4% cromolyn sodium gel exposure.
Efficacy of Navigated Laser Photocoagulation for Chronic Central Serous Chorioretinopathy: A Retrospective Observational Study
Authors: Zhou Fen , Yao Jin , Jiang Qin , Yang Weihua
Published: April 2022

Background. No consensus has been reached regarding the management of central serous chorioretinopathy (CSCR). We aimed to investigate the efficacy of navigated laser treatment for chronic CSCR and changes in the morphology of the retinal pigment epithelium (RPE). In this retrospective observational study, 19 patients with subjective symptoms admitted to the Nanjing Medical University Affiliated Eye Hospital were included between January 2021 and August 2021. All patients underwent visual acuity and optical coherence tomography (OCT) examination during follow-up. Fluorescein angiography (FA) was performed at baseline and at the final follow-up to confirm the dye leakage sites. The mean logMAR BCVA at baseline and at the end of follow-up was

0.49
±
0.24

and

0.24
±
0.15

, respectively. The mean logMAR BCVA 3 months after treatment was significantly better than that before treatment (

p
=
0.002

). Significant improvements were observed in central macular thickness (CMT) and subfoveal choroidal thickness (SFCT) after navigated laser photocoagulation (

p
<
0.0001

). Subretinal fluid was completely resolved in 13 (68%) of 19 eyes at 3 months. RPE lesions on OCT images showed RPE detachment in 17 eyes (61.5%), small protrusion of the RPE layer in 5 eyes (7.5%), and a rough RPE layer in 4 eyes (31%). After laser treatment, 9 points (35%) showed retinal detachment, and 10 (38.5%) regions showed an irregular RPE layer. An irregularly protruded RPE layer was also observed in different regions of the leakage spot in 5 (19%) eyes, and RPE defects were seen in 2 (7.5%) eyes. Navigated laser photocoagulation for chronic CSCR can achieve substantial anatomical and visual improvement. OCT outcomes may provide new information to facilitate understanding of the mechanism of chronic CSCR. Navigated laser photocoagulation should be chosen as an optimal treatment option in patients with chronic CSCR who cannot afford photodynamic therapy.
Effect of Harvesting Time and Delay in the Hulling Process on the Aflatoxin Content of Pistachio Nuts
Authors: Esmaeilpour Ali , Shakerardekani Ahmad
Published: April 2022

Harvesting time is one of the important factors that affect the quantitative and qualitative characteristics of pistachio nuts. Delaying in harvest time decreased intact nut percentage and increased cracked nut percentage. Furthermore, harvest time had significant effects on overmaturity, and the highest and lowest values were observed at the last time (Oct. 22) and at the first harvest time (Sep. 6). Results of harvesting time on aflatoxin contamination (without delay in processing) showed that the highest aflatoxin content was 0.33 ppb on October 22 and the lowest was 0.1 ppb on Sep. 6. Effects of processing delays on aflatoxin content showed that 0 and two-delay hours had no significant effects, but 12, 24, and 48-hour delays caused a significant increase in aflatoxin content. Delaying the harvest time increased the splitting percentage. Delay in processing time, increased nut staining, and aflatoxin content. The effects of harvest time and delays in processing showed that the highest stained nuts (11.3%) were found at the last harvest time and after a 48-hour delay in processing time. The lowest measured aflatoxin content at harvest was 0.1 ppb and the highest was 66.10 ppb on Sep. 6 (without delay in processing) and Oct. 22 (with 48 hours’ delay in processing), respectively. The hulling process of the harvested pistachio nuts must be carried out immediately after harvest. Processing delays must not be more than 24 hours after harvest. Considering the lowest early splitting, hull cracking, over maturity, shell staining, and aflatoxin content, September 6 is recommended as the best time to harvest pistachio nuts.
Experimental Investigation on Tribological Behaviour of Various Processes of Anodized Coated Piston for Engine Application
Authors: Meikandan M. , Karthick M. , Natrayan L. , Patil Pravin P. , Sekar S. , Rao Y. Sesha , Bayu Melkamu Beyene
Published: April 2022

In the automobile sector, pistons are anodized on the crown, on ring grooves, and also on skirts to improve its wear resistance and corrosion resistance properties. In this work, we have carried out crown anodizing along with skirt anodizing simultaneously to study the wear resistance of anodized samples. The surfaces are anodized with three different processes such as soft anodizing, hard anodizing, and microarc oxidation (MAO) or well known as plasma arc oxidation (PAO). All the three processes differ in their respective procedures. The hardness value and microstructure of all the samples were tested to find wear resistance values and the effect of coatings on the samples. In wear testing, piston samples are rubbed on cast iron to denote its wear resistance based on weight loss per unit time. Reciprocating wear testing is also carried out on every sample for testing their wear resistance value.
Dilemma of Supra- or Infrapatellar Tibial Nailing: Anterior Knee Pain vs. Intra-Articular Damage
Authors: Umur Levent , Sari Enes , Orhan Serdar , Sürücü Serkan , Yildirim Cengiz
Published: April 2022

Aim. Intramedullary nailing (IMN) is widely accepted as the treatment of choice for tibial fractures, and a suprapatellar method has been described to prevent common problems associated with the typical infrapatellar IMN technique, such as anterior knee pain. However, in the suprapatellar technique, injury to intra-articular structures is a concern. The aim of this study was to compare the clinical and radiological results of suprapatellar and infrapatellar IMN in terms of union, complications, and function. Methods. A retrospective evaluation of 61 patients who had undergone suprapatellar (n = 29, Group A) or infrapatellar (n = 31, Group B) tibial IMN was conducted. For the suprapatellar group, magnetic resonance imaging scans were acquired on the sixth month follow-up. Complications, radiological findings, functional outcomes, surgery duration, and differences in a range of motion (ROM) were compared. Results. Surgery duration was significantly shorter in Group A (81 mins vs. 107 mins,

p
<
0.001

), and visual analog scale (VAS) values were significantly higher in Group B (0.17 vs. 1.62,

p
<
0.001

). In Group A, the patients’ Lysholm scores were significantly higher (95.6 vs. 92,

p
=
0.006

). In terms of anterior knee pain, none was experienced in Group A (0%), while 11 patients (26.1%) reported about it in Group B. There were no statistically significant differences between the two groups in SF-36 score (

p
=
0.925

), the radiographic union scale in tibial (RUST) fractures score (

p
=
0.454

), union time (

p
=
0.110

), or ROM (

p
=
0.691

). In Group A, two cases of patellofemoral cartilage degeneration were observed. Conclusion. If performed with sufficient expertise, the suprapatellar IMN technique is a safe, reliable technique with a low frequency of anterior knee pain for treating tibial fractures. There is no clear evidence that it causes damage to intra-articular structures. The possibility of patellofemoral cartilage degeneration due to this technique should be further evaluated by prospective studies including pre- and postoperative radiologic assessments.
Correlation Analysis of Magnetic Resonance Imaging Characteristics and Prognosis of Invasive Pituitary Adenomas in Neurosurgery Hospitals
Authors: Bai Jinan , Li Xin , Ge Ailiang , Gu Jianhua
Published: April 2022

The incidence of pituitary adenoma is second only to glioma and meningioma, and its incidence ranks third among intracranial tumors. Most pituitary adenomas are benign and noninvasive tumors, but invasive pituitary adenomas pose a great threat to human health. In order to explore the risk factors that affect the clinical aggressive behavior of patients with pituitary adenoma, analyze the correlation between different classification methods and clinical aggressive behavior, and lay the foundation for early judgment and individualized treatment of clinical aggressive behavior of patients with pituitary adenoma. We conducted statistical research on patients who were treated for pituitary adenomas in the city’s Yangzhou Hongquan Hospital. The results of the study showed that six patients in this study showed aggressiveness in the clinical symptomatic outcome, six patients showed aggressiveness in the serological outcome, and seven patients showed aggressiveness in imaging. In the multimodal classification, the clinical aggressiveness of pituitary adenomas in the invasion + atypical group was significantly higher than that in other groups, and the difference was statistically significant (

P
<
0.05

). The correlation analysis of magnetic resonance imaging features and prognosis of invasive pituitary adenomas were verified to be feasible for the treatment of patients.
Nephroprotective Effect of Asparagus africanus Lam. Root Extract against Gentamicin-Induced Nephrotoxicity in Swiss Albino Mice
Authors: Meka Kedir Welela , Dukassa Dubiwak Abebe , Tofik Ahmed Ebsa
Published: April 2022

The kidney is the organ most vulnerable to nephrotoxic drugs such as gentamicin. Nephrotoxicity is a rapid deterioration of kidney function due to various factors. Gentamicin causes nephrotoxicity, which was manifested by an increase in serum kidney biomarkers. Asparagus africanus is one of the ethnomedicinal plants used as traditional medicine for treating various ailments, including kidney disease in Ethiopian society. Thus, the aim of this study is to evaluate the nephroprotective effect of A. africanus root extract on gentamicin-induced nephrotoxicity. Using maceration techniques, 100 g of dried plant powder was extracted in 1 L of ethanol. The physicochemical screening of plant extracts revealed the presence of flavonoids, phenols, tannins, saponins, and steroids. The nephroprotective activity of A. africanus crude extract was evaluated on male Swiss albino mice. The crude ethanolic extract at 200 and 400 mg/kg doses showed strong nephroprotective effects by restoring biomarkers such as creatinine, uric acid, and blood urea nitrogen, which were damaged by gentamicin (

p
<
0.05

) in a dose-dependent manner. The mice treated with higher doses (400 mg/kg) had a comparable nephroprotective effect compared to the positive control group (200 mg/kg silymarin;

p
>
0.05

). The histopathology of the control group showed normal glomeruli, normal parenchyma, distal convoluted, and no tubular damage. The toxicant-induced group showed damage to glomeruli and inflammatory infiltration. Therefore, A. africanus root extract has a nephroprotective activity by retarding the gentamicin toxicity in male Swiss albino mice.
Impact of the Aversive Effects of Drugs on Their Use and Abuse
Authors: Riley Anthony L. , Manke Hayley N. , Huang Shihui
Published: April 2022

Drug use and abuse are complex issues in that the basis of each may involve different determinants and consequences, and the transition from one to the other may be equally multifaceted. A recent model of the addiction cycle (as proposed by Koob and his colleagues) illustrates how drug-taking patterns transition from impulsive (acute use) to compulsive (chronic use) as a function of various neuroadaptations leading to the downregulation of DA systems, upregulation of stress systems, and the dysregulation of the prefrontal/orbitofrontal cortex. Although the nature of reinforcement in the initiation and mediation of these effects may differ (positive vs. negative), the role of reinforcement in drug intake (acute and chronic) is well characterized. However, drugs of abuse have other stimulus properties that may be important in their use and abuse. One such property is their aversive effects that limit drug intake instead of initiating and maintaining it. Evidence of such effects comes from both clinical and preclinical populations. In support of this position, the present review describes the aversive effects of drugs (assessed primarily in conditioned taste aversion learning), the fact that they occur concurrently with reward as assessed in combined taste aversion/place preference designs, the role of aversive effects in drug-taking (in balance with their rewarding effects), the dissociation of these affective properties in that they can be affected in different ways by the same manipulations, and the impact of various parametric, experiential, and subject factors on the aversive effects of drugs and the consequent impact of these factors on their use and abuse potential.
An Energy Management Strategy of Power-Split Hybrid Electric Vehicles Using Reinforcement Learning
Authors: Zhou Juanying , Zhao Jianyou , Wang Lufeng
Published: April 2022

With the rapid development of science and technology, the automobile industry is also gradually expanding due to which energy security and ecological security are seriously threatened. This paper was aimed at studying the energy organization strategy of power-split hybrid electric vehicles based on a reinforcement learning algorithm. A power-split hybrid electric vehicle (HEV) combines the advantages of both series and parallel hybrid vehicle architectures by using a planetary gear set to split and combine the power generated by electric machines and a combustion engine. This improves the fuel economy to some extent. However, to increase the fuel economy to a greater extent. This study primarily introduces the hybrid electric vehicle’s structure and presents a reinforcement learning-based management of energy approach for hybrid electric vehicles. It constructs the vehicle power model of HEV and Markov probability transfer model, then designs the energy control strategy based on reinforcement learning, and finally compares it with the energy control strategy based on PID (Proportional-Integral-Derivative). Using MATLAB/Simulink, the cycle conditions of NEDC (New European Driving Cycle) and FTP-75 (Federal Test Procedure) are selected to carry out simulation experiments. The energy management technique suggested in this study, which is based on reinforcement learning, may efficiently enhance the usage rate of automotive gasoline. The replication results show that the fuel consumption per 100 km (kilometers) based on reinforcement learning management strategy is 4.6% and 2.7% lower than the PID management strategy under two working conditions. The economy of fuel of the hybrid electric vehicle is also effectively improved.
[Retracted] A Study on Synergistic Development of Innovative Public Management and Economic Growth Based on Big Data
Authors: Guo Xiaoqin , Li Boye , Li Xiang
Published: April 2022

Since the twenty‐first century, the Internet of Things technology has developed rapidly, and its impact on China’s economy and society is far‐reaching, and its significance is also far‐reaching. This makes more and more scholars start to pay attention to the related issues of the Internet of Things and economic development. The Internet of Things provides a superior information platform for various economic entities, enabling economic exchanges to transcend the boundaries of time and space. The IoT generates a lot of big data, and it is not easy to get valuable insights from the huge amount of data in various formats, ensuring that sensors are working properly and data is transmitted securely and processed efficiently. In order to study the role of the Internet of Things in promoting economic growth, clarify the status of the Internet of Things in the national economy and explore public management innovation as a change in actual social relations. This paper analyzes the application of the Internet of Things technology in public management. In order to deal with the massive multisource heterogeneous data involved in public management, this paper proposes a resource optimization scheduling algorithm for differentiated distributed storage systems and focuses on the analysis of China’s economic growth in recent years. Through experiments, it is found that from 2014 to 2020, China’s economy will continue to maintain rapid growth, with a GDP of 101,5986 billion yuan. Since 2014, the number and quality of R&D personnel in China have increased significantly. In 2020, due to the resumption of growth in corporate profits in the second half of the year, the cumulative decline in revenue will result in a decline in domestic value‐added tax by 8.9% and corporate income tax by 2.4%.
Peripheral Neural Sheath Breast Sarcoma: Case Report and Literature Review
Authors: Forero Yency Johana , Zapata Laguado Martín Ignacio , Briceño Ximena , Brugés Ricardo Elías , Contreras Fernando
Published: April 2022

Primary sarcomas of the breast are heterogeneous neoplasms derived from the non-epithelial elements of the mammary gland. Malignant peripheral nerve sheath tumors comprise 5–10% of all malignant soft tissue sarcomas. Its heterogeneity and low incidence (1 in 100,000) limit the performance of prospective studies. Therefore, most published articles include individual reports and case series with a small number of patients, making it impossible to determine clear treatment standards in this scenario. A 36-year-old young woman with no personal history consulted the National Cancer Institute of Colombia with a 1-year progression of a rapidly growing mass in her left breast until reaching an approximate tumor size of 20 × 20 cm. Histopathological analysis with a tru-cut biopsy taken from the lesion revealed the presence of a breast sarcoma with positive staining for SOX-10 and S-100. A radical mastectomy as her first treatment included the resection of a costal arch and, therefore, the reconstruction of the chest wall with coverage of the defect with an extended latissimus dorsi flap followed by consolidation therapy with adjuvant radiotherapy (RT) and chemotherapy. Evidence regarding malignant peripheral nerve sheath sarcoma of the breast treatment corresponds to retrospective analyses and case reports with high heterogeneity and variability about strategies in surgical procedures and adjunctive therapy such as complementary chemotherapy and RT; therapeutic approach should always include a multidisciplinary team.
Human Immature Dental Pulp Stem Cells Did Not Graft into a Preexisting Human Lung Adenocarcinoma
Authors: da Silva Joyce Macedo , Araldi Rodrigo Pinheiro , Colozza-Gama Gabriel Avelar , Pagani Eduardo , Sid Ariye , Valverde Cristiane Wenceslau , Kerkis Irina
Published: April 2022

Mesenchymal stem cell (MSC)-based therapies have been considered an attractive approach for treating Huntington’s disease (HD). However, due to the pulmonary first-passage effect associated with intravenous infusion (the most commonly used route of MSC administration), there is a rising concern that the cells could be entrapped in the lungs and grafted (homing) into preexisting lung cancer. Herein, we report the case of a patient with HD enrolled in a cell therapy phase I clinical trial for HD treatment having a preexisting pulmonary nodule. The nodule was found at the trial screening. The patient was referred to a pulmonologist who considered the nodule non-cancer and authorized enrollment. The patient received four intravenous administrations of human immature dental pulp stem cells (hIDPSCs) at the dose of 1 × 106 cells/kg of body weight within 2 years. One month after the last dose, a computerized tomography scan showed nodule growth. A bronchoscopy biopsy showed primary lung adenocarcinoma. The neoplasm was surgically excised (lung superior right lobectomy). The patient is cured of the neoplasm. The tumor was sectioned into six fragments, which were subjected to RNA-seq. The transcriptome of each tumor section was compared with the transcriptome of infused hIDPSCs using two statistical approaches: principal component analysis and NOIseq. Both results demonstrated a linear distance between the hIDPSCs and the lung adenocarcinoma. These results suggest that the infused hIDPSCs neither home nor graft within the pulmonary nodule.
A Case of Hepatopulmonary Syndrome as a Complication of Metastatic Breast Cancer to the Liver
Authors: Coggan James , Morin Adam , Rao Ruta
Published: April 2022

Many patients with metastatic breast cancer develop liver metastases. A rare complication of this is hepatopulmonary syndrome (HPS), which is associated with exertional dyspnea and intrapulmonary shunting. We present a patient who presented with HPS as a consequence of liver metastases and subsequently treated with chemotherapy leading to resolution of her symptoms.
Inclusión educativa en pandemia: interseccionalidad y situación de menores venezolanos en Bogotá
Authors: Rodríguez-Lizarralde Carolina , López-Villamil Stephanie , Barrera-García Angie Daniela
Published: April 2022

(analítico)El objetivo de este artículo es comprender las dinámicas de inclusión de niñas, niños y adolescentes venezolanos en los flujos migratorios internacionales en la ciudad de Bogotá. A partir de una investigación mixta, se presentan cifras frente a la relación migración y derecho a la educación, complementadas con entrevistas semiestructuradas y grupos focales a representantes de instituciones, organizaciones de la sociedad civil y agencias internacionales, así como resultado de talleres de cartografía social con menores venezolanos. El análisis se realiza desde el enfoque de interseccionalidad en los entornos escolares, más allá de la escuela. Se evidencia que los desarrollos frente a las intersecciones entre edad, género, etnia, discapacidad, clase social, entre otras, son bastante precarios en los estudios de migración en Colombia.
Palabras clave: Colombia; educación; migración venezolana; niñez; pandemia.