bluuebunny/crossref_metadata_2025 huggingface dataset:
Mechanical Failure of Angle Locking Plates in Distal Comminuted Tibial Fractures
Authors: Ene Razvan , Panti Zsombor , Nica Mihai , Pleniceanu Marian , Ene Patricia , Cîrstoiu Monica , Antoniac Iulian Vasile , Cirstoiu Catalin
Published: May 2016

Distal comminuted tibial fracture with or without intra-articular involvement is a very common injury of the lower limb, especially in younger patients due to high energy trauma. The anatomical and biomechanical properties of this segment of tibia, makes this pathology a major surgical challenge with a preserved clinical outcome. The aim of this study is to present different outcome of tibial fracture, treated with open reduction and internal fixation (ORIF) with titanium angle locking plates (ALP) and to underline the physiological and non-physiological bone healing effects on implants. In this study we included 48 patients with tibial pilon fracture who underwent to ORIF, applying ALP in the Orthopedics and Trauma department of the University Emergency Hospital in Bucharest. Due to preserved biomechanical properties of ALP and this anatomical region, weight bearing is not allowed till 6 to 8 weeks. Comminuted fracture of this part of tibia often have de-vascularized bony fragments which leads to delayed union or non-union. These complications often lead to implant failure, improper bone healing or non-union. Internal fixation with angle stable screws, offers a good stability of reduction in the early postoperative period. Titanium angle locking plates offers good anatomical reduction and stable fixation in the early period of healing process. Due to its rigid, fixed position of the screws in the plates, bone remodelling during healing process and early weight bearing, increases the mechanical failure of implant.Keywords: tibial pilon fractures, angle locking plates, implant failure.
Comparative Study Regarding Two Obturation Methods with Thermoplasticized Gutta-Percha for the Root Canals
Authors: Ţuculină Mihaela Jana , Gheorghiţă Lelia , Diaconu Oana Andreea , Bătăiosu Marilena , Dascălu Ionela Teodora , Popescu Sanda Mihaela , Manolea Horia Octavian , Scrieciu Monica
Published: May 2016

AIM: This study draws a comparison, through the transparentization method, focusing on the quality of the canal obturation made with thermoplasticized gutta-percha, between two different systems: GuttaMaster VDW (München, Germany), based on obturators made of a plastic core, covered in alpha gutta-percha, and a system of vertical warm condensation.MATERIALS AND METHODS: The study focused on twenty teeth extracted for various reasons which underwent the endodontic treatment realized through a hybrid technique, using the rotary files system of NiTi MTWO (VDW, München, Germany), and the manual files k-file type (Kendo, VDW, München, Germany). The teeth were distributed into two groups of ten. The teeth in the first group underwent obturation using the CWC technique of vertical warm obturation, and the teeth in the second group underwent root obturation using the GuttaMaster system (VDW, München, Germany). The teeth were decalcified in nitric acid. Using the method of transparentization with methyl salicylate, there were emphasized aspects regarding the abilities of each method to seal three-dimensionally the endodontic space.RESULTS: The teeth which underwent vertical obturation presented many more holes in the obturation material, holes situated mainly in the medial and coronary third. However, these teeth presented the highest degree of insertion in the lateral canals, as compared to the other obturation technique employed. The homogeneity of the root obturation had not had any statistical significant differences between the two techniques. However, the technique of injecting thermoplasticized gutta-percha was superior to the other one regarding the tightness on the edge and the degree of penetration in the lateral canals.CONCLUSIONS: The knowledge of both the qualities and the limits of the obturation material chosen, as well as the correctness of performing the two techniques, determines a definite improvement of the quality of the canal treatment, which ends with a three-dimensional canal obturation.
Wollastonite and Calcium Phosphate Biocoatings with Zn- and Cu-Incorporation Produced by a Microarc Oxidation Method
Authors: Sedelnikova Maria B. , Komarova Ekaterina G. , Sharkeev Yurii
Published: May 2016

Investigations of wollastonite and calcium phosphate biocoatings with Zn-and Cu-incorporation produced by a microarc oxidation method were presented. Dependences of coating properties on the microarc oxidation parameters were revealed. A variation of the process parameters allowed us to produce wollastonite-calcium phosphate coatings with a plate-like structure, thickness of 25–30 μm, roughness of 2.5–5.0 μm, and enhanced strength properties. Coatings based on substituted hydroxyapatite deposited under voltages of 200–250 V have an X-ray amorphous structure. An increase of oxidation voltage to 300 V leads to the formation of crystalline phases in the coating, such as CaHPO4 and β-Ca2P2O7. The maximum content of 0.4 at% zinc and 0.1 at% copper was obtained for coatings based on Zn-and Cu-substituted hydroxyapatites, consequently, deposited under oxidation voltage of 250 V.
Randomized Clinical Trial of Adhesive Restorations in Non Carious Cervical Lesions
Authors: Popescu Sanda Mihaela , Ţuculină Mihaela Jana , Manolea Horia Octavian , Mercuţ Veronica , Scrieciu Monica
Published: May 2016

AIM: To evaluate the clinical performance of adhesive restorations of resin-modified glass-ionomer cements (RMGIC) compared with of resin composite (RC), and RMGIC liner base laminated with a resin composite in non carious cervical lesions (NCCL).METHODS: The randomized clinical trial included 45 patients (25-65 year-old), with at least two similar sized NCCL on premolars. After sample size calculation, 220 restorations were placed, according to one of the following groups: (G1) Resin-modified glass-ionomer cement (Vitremer); (G2) a resin composite and an adhesive layer (Versaflo); (G3) RMGIC liner base laminated with a resin composite (Vitremer and Versaflo). The restorations were clinically followed every 6 months for up to 24 months using the USPHS modified criteria for clinical evaluation. Survival estimates for restoration longevity were evaluated using the Kaplan-Meier method. Log-rank test (P< 0.05) was used to compare the differences in the success rate according to the type of the restorative material.RESULTS: At the end of 24 months, 172 restorations were evaluated in 37 patients, with a recall rate of 82.22%. The type of restorative material used did not influence the longevity of the restorations. The survival rates for the follow-up were similar regarding the number of restored surfaces and the tooth (upper or lower premolar). Estimated survival rates of the restorations were 100%, 100%, 98,25% and 90,69% at 6, 12, 18 and 24 months of clinical evaluations, respectively. A statistically significant difference was observed between RMGIC and RC or RMGIC laminated with RC for color match, but no other significant difference was observed among the three types of restorations.CONCLUSIONS: The survival rates were similar for the three types of restorations in NCCL. Different types of materials demonstrated acceptable clinical performance in non-carious cervical lesions.
Hyaluronic Acid - Innovative Therapeutic Principle
Authors: Ştirbu Ionel Cristian , Popescu Sanda Mihaela , Ţuculină Mihaela Jana , Mercuţ Veronica , Manolea Horia Octavian , Iorgulescu Daniel
Published: May 2016

The article presents the experience of a new therapeutic method, addressing postoperative implant pathology.Methods: Hyaluronic acid has been used in the management of various mucoperiosteal pathologies (directing secondary healing of oral wounds, restoration / increasing the volume of connective tissue – periosteal preoperativ or the papillary volume).Hyaluronic acid used had different concentration. The presentation forms both viscous and fluid particle size and type/acid’s grade of complexation) provided various therapeutic effects with specific indication of administration respected by the authors. Different products available at this time in Romania were used analyzing the results in time.Results: This therapeutic approach provided a good management in secondary granulation and wound healing of oral tissues in difficult cases (GBR, implant therapy) in which the persistence of dehiscence wound can cause a failure of surgical treatment (loss of membrane, alloplastic material or implant).Conclusion: This results places this innovative therapeutic method with others successful therapeutic solutions in usual dental practice, providing a quick and efficient settlement of some difficult clinical cases.
Mesoporous Silica Coating on Rf-Sputtered Apatite/Titanium Substrate
Authors: Yokogawa Yoshiyuki , Kitano M. , Hiroyasu K.
Published: May 2016

The preparation of mesoporous silica coated rf-sputterd apatite / titanium substrate and protein adsorptive property is reported. Hydroxyapatite coated titanium implant has been used, and the adsorption of proteins onto implant is very important for bond formation between bone and implant. Mesoporous silica (MPS) materials have been extensively studied as carriers of bio-molecules due to their potential practical applications in medical materials. Pore diameters of 1.5 – 30 nm of the periodic mesoporous materials are close to the diameters of target molecules and high adsorbed amount of proteins onto MPS has been reported, and also enclosure of the protein in a well-defined space may help to prevent denaturation. Previously, we reported the MPS coating on the porous hydroxyapatite (HAp) ceramics obtained by dip-coating method, and by the vapor phase synthesis. Protein adsorption on the porous HAp with the MPS coatings was evaluated using UV-VIS spectrometry, and the quantity of adsorbed amount of protein was remarkably improved. In this study, the HAp deposition on Ti substrate (HAp/Ti) was carried out by rf magnetron sputtering and hydrothermal treatment, and MPS coating on HAp/Ti using LB deposition apparatus to improve the protein adsorptive property of HAp/Ti. The quantity of adsorbed protein onto the HAp /Ti was around 12 times high, and that onto the MPS/HAp/Ti was 18 times high compared to that on Ti substrate.
Quantitative Estimation of Connectivity among Pores in the Hydroxyapatite Scaffold Prepared by Slip Casting with Porogen
Authors: Lee Min Chul , Chung Tai Joo , Oh Kyung Sik
Published: May 2016

The connectivity of pores in the hydroxyapatite scaffold was quantitatively estimated by the infiltration of a setting resin in the scaffold and was evaluated by counting the number of pores filled with resin. As pore filled resin indicated the connection with at least one neighboring pore and outside, the volume fraction of the filled pores corresponded to the connectivity previously defined. For the specimen with 88% of connectivity, the scaffold successfully showed cellular migration and bone growth even at the deep part of the scaffold by the in vivo test. Thus, the connectivity evaluated in this study is a useful criterion for the prediction of successful cellular migration.
Effects of Surface Properties of Montmorillonite for their Cytocompatibility
Authors: Nakanishi Ko , Abe Shigeaki , Yamagata Shuichi , Yoshida Yasuhiro , Iida Junichiro
Published: May 2016

We modified the surface of organically modified montmorillonite (OMMT) with the carboxyl group using the silane coupling reaction and assessed its characteristics and cytocompatibility. Scanning electron microscope observations show that while the size and morphology of the obtained OMMT (OMMT-COOH) was unchanged, the surface of OMMT-COOH was coarser than that of OMMT. Fourier transform infrared spectra showed characteristic strong peaks at 1210 and 1630 cm−1, corresponding to the peaks of the carboxyl group. X-ray diffraction analysis showed that the diffraction peak of OMMT-COOH corresponding to the (001) reflection was located at higher a 2θ value than that of OMMT. Results of the proliferation ratio and cell viability measurements indicated that the OMMT-COOH cytocompatibility is higher than that of OMMT. Based on these results, we conclude that cytocompatibility of montmorillonite would be improved by tuning the properties of the surface.
Threshold Voltage Instabilities of Present SiC-Power MOSFETs under Positive Bias Temperature Stress
Authors: Rescher Gerald , Pobegen Gregor , Grasser Tibor
Published: May 2016

We study the threshold voltage (Vth) instability of commercially available silicon carbide (SiC) power MOSFETs or prototypes from four different manufacturers under positive bias temperature stress (PBTS). A positive bias near the Vth causes a threshold voltage shift of 0.7 mV per decade in time per nanometer oxide thickness in the temperature range between-50 °C and 150 °C. Recovery at +5 V after a 100 s +25 V gate-pulse causes a recovery between-1.5 mV/dec/nm and-1.0 mV/dec/nm at room temperature and is decreasing with temperature. All devices show similar stress, recovery and temperature dependent behavior indicating that the observed Vth instabilities are likely a fundamental physical property of the SiC-SiO2 system caused by electron trapping in near interface traps. It is important to note that the trapping is not causing permanent damage to the interface like H-bond-breakage in silicon based devices and is nearly fully reversible via a negative gate bias.
Effect of Ca Contents on Tensile Properties of Squeeze Cast Mg-Al-Ca Alloys
Authors: Zhou Jun Xiang , Masoumi Mohsen , Hu Henry
Published: May 2016

In this study, the effect of calcium contents on tensile properties of squeeze cast Mg-Al-Ca alloys at room temperature was investigated. The results show that as the calcium content of AMC50X increases from 0 to 4 wt.%, the ultimate tensile strength (UTS) and elongation-to-failure (Ef) decrease dramatically at room temperature. But, the yield strengths (YS) of the alloys improve slightly.
Regeneration Kinetics Study of Fe2O3 Desulfurization Sorbents in SO2 Atmosphere
Authors: Zhao Xiao Wei , Ju Shang Guan , Wang Hui Qing , Liu Li Ping , Mi Jie
Published: May 2016

The influences of the regeneration temperature and SO2volume fraction on regeneration kinetics behavior of Fe2O3 sorbent as a high-temperature desulfurization sorbent were researched by TGA (Thermos gravimetric analyzer) in this work. The main regeneration product of iron oxide desulfurization sorbent was Fe2O3 and sulfur in SO2 atmosphere which has an important practical significance for pollution control of H2Sandrecycleofsulfur. The results indicate that Fe2O3 desulfurization sorbent was completely regenerated at temperature of 725-775 °C and the higher regeneration temperature and volume fraction of SO2 is benefit to improve regeneration reaction rate. The regeneration reaction of Fe2O3 sorbent in SO2atmosphere can be first order reaction obtained by the equivalent grain model, and the controlling process of regeneration reaction is change from the chemical reaction control to the diffusion control in the whole regeneration process. The chemical reaction apparent activation energy and the corresponding frequency factor of chemical reaction are 145.31 kJ/mol and 0.0063 m/s, respectively. And that of diffusion are 50.73 kJ/mol and 4.38×10-3 m2/s, respectively.
The Effect of Excess Sodium Element on KNN-BF Piezoelectric Ceramics
Authors: Zhao Duo , Fu Xing Hua , Cheng Guo Yuan , Tao Wen Hong , Zhao Yue , Zhao Li Ping , Ma Wen Xin
Published: May 2016

Lead-free (K0.5Na0.5)0.992Nb0.992-0.008BF-xNa (KNN-BF-xNa) piezoelectric ceramics with excess Na doping were synthesized using the sol-gel method at the sintering temperature of 1100°C. The effects of excess Na-doping on microstructure and properties of the lead-free piezoelectric ceramics were systematically investigated with x from 0.00 to 0.04. As x increased into 0.03, the acutest peak of x-ray diffraction patterns appeared; the SEM fig.1(c) showed regular and dense crystal shape. KNN-BF-0.03Na ceramics showed excellent properties of d33=149pC/N, εr=641(f=1KHz), tanδ=0.06(f=1KHz), ρ=4.15g/cm3. The results indicated that excess Na doping can make up for the Na volatilized while sintering under atmosphere pressure, but as x was 0.04, too much more Na dropping would lower the sintering temperature. Therefore, there would be quantities of liquid phases, as was shown in the fig.1(d), which caused the inferior properties of piezoelectric ceramics.
Mechanical Properties of Modified Epoxy/Rubber Concrete
Authors: Shu Xing Wang , Zhang Ying
Published: May 2016

To research the effect of a elastic modifier on the mechanical properties of epoxy/rubber concrete, series of epoxy/rubber concretes were prepared with different elastic modifier content, the relationship between elastic modifier content and stress-strain curve of epoxy/rubber concretes were investigated. Results show: as the increase of elastic modifier content, both the compressive and bending stress-strain curves of epoxy/rubber concretes experience a stage transition of elastic-elastoplasticity-plastic apparently; the slope in the rising and falling section of stress-strain curves are gradually decreased; the peak stress decrease while the corresponding strain and stain energy increase. Content of elastic modifier between 40pbw and 60 pbw is proposed in order to attain better properties of epoxy/rubber concrete. Compared with ordinary concrete and rubberized concrete, Improved epoxy/rubber concrete has better comprehensive mechanical properties and larger rubber content.
In Vivo Efficacy and Tolerability of Artesunate–Azithromycin for the Treatment of Falciparum Malaria in Vietnam
Authors: Phong Nguyen Chinh , Quang Huynh Hong , Thanh Nguyen Xuan , Trung Trieu Nguyen , Dai Bui , Shanks G. Dennis , Chavchich Marina , Edstein Michael D.
Published: May 2016

Safe and effective antimalarial drugs are required for the treatment of pregnant women. We report a 3-day regimen of artesunate (4 mg/kg/day)–azithromycin (25 mg/kg/day) (ASAZ) to be efficacious (polymerase chain reaction–corrected cure rate of 96.7%) and well tolerated in the treatment of Plasmodium falciparum malaria in children (N = 11) and adults (N = 19), in Vietnam in 2010. In comparison, the cure rate for artesunate (4 mg/kg on day 0, 2 mg/kg on days 1–6) was 90.0% in children (N = 7) and adults (N = 23). Because azithromycin is considered safe in pregnancy, our findings provide further evidence that ASAZ should be evaluated for the treatment of pregnant women with malaria.
Planning for climate change impacts on hydropower in the Far North
Authors: Cherry Jessica E. , Knapp Corrie , Trainor Sarah , Ray Andrea J. , Tedesche Molly , Walker Susan
Published: May 2016

Abstract. Unlike much of the contiguous United States, new hydropower development continues in the Far North, where climate models project precipitation will likely increase over the next century. Regional complexities in the Arctic and sub-Arctic, such as glacier recession and permafrost thaw, however, introduce uncertainties about the hydrologic responses to climate change that impact water resource management. This work reviews hydroclimate changes in the Far North and their impacts on hydropower; it provides a template for application of current techniques for prediction and estimating uncertainty, and it describes best practices for integrating science into management and decision-making. The growing number of hydrologic impacts studies suggests that information resulting from climate change science has matured enough that it can and should be integrated into hydropower scoping, design, and management. Continuing to ignore the best-available information in lieu of status quo planning is likely to prove costly to society in the long term.
Hydrological corridors for landscape and climate restoration: Prioritization of re-greening areas in Kenya and Tanzania
Authors: Klostermann Judith E. M. , Fleskens Luuk , Querner Erik , Ter Maat Herbert , Hutjes Ronald , Jaspers Fons , de Haas Sander
Published: May 2016

Abstract. The Naga Foundation aims to implement durable re-greening interventions to increase local soil sustainability and regional water availability. When this is done on a large enough scale such landscape changes may also lead to positive regional climate impacts. Naga is developing a plan to re-green 15 large areas in Eastern Africa, creating a so-called hydrological corridor. Four potential hydrological corridors have been identified in Kenya and Tanzania, all four of them around Mount Kilimanjaro. To select the most promising corridor, a method was developed to support a decision in a situation where few data are available. The method is based on maps, models and literature from four different disciplines concerning soil, water, climate and social institutions. The findings favour the Tanzanian corridors and especially the Tanzania-East one, to start with re-greening projects. In that region many applicable land management options combine with a high potential for restoring soil organic matter, the highest rainfall recycling potential exists in the more favourable long rains season, while finally also the Tanzanian governments both at national and at local level seem more dependable for supporting hydrological corridor implementation.
El títere como herramienta de trabajo en Arteterapia
Authors: Mesas Escobar Eva Cristina
Published: May 2016

El presente artículo pretende indagar en las posibilidades propias de la construcción de títeres en el taller de arteterapia, para ello se realiza un recorrido que parte del uso primitivo del títere como doble mágico y potencial hacia el estudio de autores que han utilizado los títeres como herramienta terapéutica desde la primera mitad del siglo XX. Se plantea un cuerpo teórico propio, que incluye el considerar la significación del cuerpo en la construcción y manejo del títere, y la perspectiva transional del títere, a medio camino de la realidad externa y la realidad psíquica, como objeto que fabrica fantasía y construye realidad.
Del pictograma a la imagen: herramientas de comunicación y lenguaje en personas con síndrome de Asperger a través de recursos visuales para la inclusión social
Authors: Regis Sansalonis Pedro José , Callejón Chinchilla María Dolores
Published: May 2016

Se presenta en este texto, una introducción al Síndrome de Asperger y aquellas características que lo distinguen, con el fin de conocer un poco más, en qué consiste este Trastorno Generalizado del Desarrollo (TGD). Además, se pretende facilitar cuales son las herramientas de comunicación y lenguaje más aptas para la enseñanza y aprendizaje del sujeto, haciendo hincapié en los recursos visuales, audiovisuales y artísticos como herramientas de aprendizaje para su inclusión social en cualquier ámbito de la sociedad (colegios, institutos, asociaciones, universidades o administraciones).
Hva betyr de enkelte dødsårsaksgrupper for utdanningsforskjellene i dødelighet?
Authors: Elstad Jon Ivar , Hofoss Dag , Dahl Espen
Published: May 2016

Artikkelen analyserer utdanningsforskjellene i dødelighet og undersøker hvilke dødsårsaksgrupper som særlig bidrar til de sosioøkonomiske helseforskjellene. Data kommer fra Statistisk sentralbyrås database FD-Trygd. Analyseutvalget består av praktisk talt alle bosatte i Norge i 1993 alder 25-66 år (N = 2,2 millioner). Data har informasjon om utdanning og dødsfall/dødsårsaker 1994-2003 og ble analysert med logistisk regresjon (utfallsvariabel død/ikke-død 1994-2003 alle årsaker samlet og 18 dødsårsaksgrupper, aldersjustert). Beregninger av hvor mange dødsfall som kunne være unngått om dødsrisiko for alle hadde vært lik den faktiske risiko for høyere universitetsutdanning er foretatt. Analysene viste at oddsratioer (OR) for dødsfall, alle årsaker, økte systematisk med synkende utdanningsnivå. Utdanningsforskjellene var spesielt store for stoffmisbruksrelaterte dødsfall og over gjennomsnittet for alkoholrelaterte dødsfall, lungekreft, kroniske lungelidelser. Variasjonene med utdanning var også særlig store for ischemisk hjertesykdom blant kvinnene. De fleste kreftformene unntatt lungekreft viste forholdsvis små utdanningsforskjeller. Blant kvinnene var det ingen utdanningsulikhet for tykk/endetarmskreft, brystkreft, selvmord og trafikkulykker. Om dødsrisikoen i alle utdanningsgrupper hadde vært lik risikoen blant dem med høyere universitetsutdanning ville 43 000 av de 104 000 dødsfallene som faktisk fant sted 1994-2003 vært unngått. Dødsfall i hjerte- og karlidelser, lungekreft og kronisk lungesykdom sto for nær 60% av de ”ekstra” dødsfallene for begge kjønn. Store helsegevinster vil oppnås om utdanningsforskjellene i dødelighet reduseres. En minsking av ulikhetene i dødelighet i hjerte- og karlidelser, lungekreft og kronisk lungesykdom ville ha særlig betydning for å redusere de samlete utdanningsforskjellene i dødelighet.
Sosial ulikhet i ungdoms helse: Er helseatferd viktig?
Authors: Torsheim Torbjørn , Leversen Ingrid , Samdal Oddrun
Published: May 2016

Studier har påvist sosioøkonomiske forskjeller i ungdoms helse. I følge atferdsforklaringer på ulikhet har ungdom fra familier med lav sosioøkonomisk status dårligere helse som et resultat av at de har et høyere nivå av risikoatferd og et lavere nivå av beskyttende atferd. Det empiriske grunnlaget for en slik forklaring er imidlertid svakt. Målet med studien var å undersøke rollen helseatferd kan ha for sosioøkonomiske forskjeller i ungdoms helse. Studien bygger på data fra den norske delen av ”Helsevaner blant skoleelever 2005/06”. Et utvalg av 6447 skoleelever i aldersgruppen 11 til 16 år besvarte spørreskjemaer. Sosioøkonomisk status ble målt med en indeks for foreldrenes status bestående av foreldrenes yrke, familiens velstand og antall bøker i hjemmet. Helseatferd ble målt ved epidemiologiske indikatorer for kosthold, fysisk aktivitet, stillesittende aktivitet/ser mye på tv, røyking og alkoholbruk. Ordinal logistisk regresjonsanalyse viste at ungdom med lav status hadde høyere odds ratioer for selvrapportert dårligere helse. Kontroll for helseatferd resulterte i en klar reduksjon i odds ratioen for dårligere helse, en indikasjon på delvis mediering. Stianalyse indikerte at røyking, fysisk aktivitet og inntak av frukt og grønnsaker bidro til mediering av sammenhengen mellom sosioøkonomisk status og selvrapportert helse. Samlet tyder resultatene på at helseatferd kan være en medierende mekanisme for sosioøkonomiske forskjeller i ungdoms helse. Langtidskonsekvensen av helseatferd antyder et behov for intervensjoner som retter seg mot flere former for helseatferd.
The Medical Birth Registry of Norway – An international perspective
Authors: Wilcox Allen J.
Published: May 2016

Some of the most practical questions of perinatal medicine are regarding couples who have had pregnancy problems in the past, and their risk of having such problems in future pregnancies. For example, if a couple has a child with a birth defect, what are their chances that their next child will have a defect? The key to answering such questions is the availability of linked data such as those provided by the Medical Birth Registry of Norway. Such linked data provide a unique resource for addressing a broad range of questions in perinatal epidemiology. The Medical Birth Registry of Norway has been a pioneer in answering such questions
Registerbasert epidemiologisk forskning og forvaltning – et resultat av tilfeldighetenes spill eller en uunngåelig historisk utvikling?
Authors: Irgens Lorentz M.
Published: May 2016

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POLIMIXINA INTRAVESICAL NO TRATAMENTO DE CISTITE POR KPC
Authors: Fagundes Grobe Sarah , Albanski Raboni Lenisa , Perussolo Alberton Helen Carolina , Tuon Felipe Francisco
Published: May 2016

A crescente incidência de Klebsiella pneumoniae produtora de carbapenemase (KPC) tornou-se um desafio para a saúde pública. Além de conferir resistência a várias classes de antibióticos diferentes, incluindo os β-lactâmicos, carbapenêmicos, fluoroquinolonas e aminoglicosídeos, as infecções consequentes à essa bactéria estão associadas com elevadas taxas de mortalidade e de falhas terapêuticas em pelo menos metade dos casos.Atualmente, o grande desafio está no limitado arsenal de antimicrobianos disponível para tal tratamento. Sob esse cenário, novas modalidades de tratamento são necessárias, com urgência.Sendo assim, buscou-se descrever um caso na tentativa de institutir e informar uma via alternativa, segura e eficaz no tratamento desses pacientes, assegurando menor tempo de internamento e, consequentemente, diminuição de custos hospitalares.
QUIZ: Paciente com úlceras em braços
Authors: Moreira Eduardo Martelli , Maccalli Claudia , Neidert Josiane Aparecida , Peretti Murilo Calvo , Carvalho Mauricio , Dallolmo Ottoboni Vanessa Cristhine , Mukai Maira Mitsue
Published: May 2016

Caso Clínico: Homem de 65 anos, diabético tipo 2, e em tratamento por hanseníase virchowiana (10a cartela de rifampicina, clofazimina e dapsona) foi admitido na enfermaria da Clínica Médica por lesões ulcerativas nas faces extensoras de membros superiores. Duas semanas antes do internamento procurou atendimento médico em outro serviço por quadro de febre, inapetência e convulsões (sic), para o qual foi prescrito ceftriaxona por 5 dias. No 3o dia de tratamento, surgiram lesões inicialmente pustulosas, que evoluíram para úlceras confluentes. Estas lesões localizavam-se principalmente em cotovelos, mas acometiam também antebraços e pernas. Ao exame físico, apresentava linfonodomegalia cervical anterior, madarose e fígado palpável a 1 polpa digita do rebordo costal direito. Qual o diagnóstico?
CARCINOMA HEPATOCELULAR – UMA REVISÃO BIBLIOGRÁFICA
Authors: Vianna Bruno Leal , Muncinelli João Felipe Galbiatti , Garcia Rafael Eduardo , Tomasich Flávio Daniel Saavedra
Published: May 2016

Introdução: globalmente, são diagnosticados mais de meio milhão de casos de carcinoma hepatocelular (CHC) ao ano. É o terceiro câncer em mortalidade e o sexto em incidência. Os fatores de risco são bastante conhecidos e descritos na literatura - a cirrose, o principal deles, é encontrada em 90% dos casos. Em termos globais, a etiologia mais comum é o vírus da hepatite B (HBV), seguido do vírus da hepatite C (HCV). Material e métodos: realizada uma busca na base de dados do Medline a partir da ferramente MeSH do site Pubmed no dia 11 de março de 2014. Foram usadas como palavras-chave: “carcinoma hepatocellular/epidemiology”. Restringindo a revisões sistemáticas ou revisões publicadas nos últimos 5 anos, foram encontrados 154 artigos. A partir da leitura do título e abstract, o número foi reduzido a 52. Adicionalmente, incluímos artigos referenciados nos trabalhos selecionados. Resultados e Discussão: a distribuição do CHC no mundo é bastante heterogênea e dinâmica. Oitenta e dois por cento dos novos casos concentram-se em países em desenvolvimento, com a China contemplando sozinha 55%. Localidades de alta incidência de CHC normalmente são endêmicas para o HBV. Já em regiões de baixa incidência para o câncer, a etiologia predominante é o HCV. Somados, os vírus são encontrados em 80% de todos os casos. Outra característica é o maior comprometimento de homens – no Brasil, 78%. Os fatores de risco, além dos vírus, são o etilismo, hemocromatose, aflatoxina B1, hepatite autoimune, obesidade, Diabetes, Doença Hepática Gordurosa Não-Alcoólica (NALFD), Esteatohepatite Não-Alcoólica (NASH) e tabagismo.
CATETERIZAÇÃO DE SEIO PETROSO INFERIOR NO DIAGNÓSTICO DE SÍNDROME DE CUSHING
Authors: Friedrich Vanessa Cristina Ribeiro , Schwambach Felipe Wolff , Manosso Karina Zanlorenzi Basso , Vensão Leilane , Romanzini Nicole Balster , Pallone Sthefanie Giovanna , Lovozoy Thayse Graciella , Boguszweski César Luiz
Published: May 2016

Introdução: 15% dos casos de síndrome de Cushing ACTH-dependente devem-se a tumor ectópico. Técnicas bioquímicas e radiológicas têm sido desenvolvidas para ajudar na distinção entre produção ectópica ou hipofisária de ACTH. Objetivo: Relato de síndrome de Cushing ACTH-dependente, cuja definição diagnóstica foi realizada por cateterização bilateral de seio petroso inferior. Relato de caso: Mulher, 47 anos, com amenorreia, ganho de peso, fraqueza, hipertensão arterial, osteoporose e transtorno de humor. Ao exame, fácies em lua cheia e giba dorsal, estrias violáceas abdominais de 1,5 cm, membros inferiores com edema. A investigação laboratorial detectou hipercortisolismo ACTH-dependente. Teste de supressão com dexametasona (16 mg) sugeriu produção ectópica de ACTH. Entretanto, exames de imagem não detectaram lesões no sistema nervoso central ou fora dele responsáveis pelo excesso hormonal. A paciente foi encaminhada a outro serviço para realização de cateterização de seio petroso inferior, que não evidenciou gradiente entre os níveis de ACTH dosados próximo à glândula comparados à periferia, confirmando a origem ectópica do ACTH. Novos exames de imagem evidenciaram tumor em timo. Paciente foi submetida à videotoracoscopia com exérese da lesão, recebendo alta no 10º pós operatório com normalização dos níveis de cortisol e ACTH. Conclusão: A cateterização bilateral de seio petroso inferior é o teste que oferece maior sensibilidade e especificidade na diferenciação entre produção hipofisária e ectópica de ACTH. Uma vez que os exames de imagem iniciais não evidenciaram tumor, esse teste foi essencial na confirmação da etiologia ectópica do ACTH, o que motivou nova investigação e, consequente, diagnóstico e tratamento.
Texting Dependence, iPod Dependence, and Delay Discounting
Authors: Ferraro F. Richard , Weatherly Jeffrey N.
Published: May 2016

We gave 127 undergraduates questionnaires about their iPod and texting dependence and 2 hypothetical delay discounting scenarios related to free downloaded songs and free texting for life. Using regression analyses we found that when iPod dependence was the dependent variable, Text2-excessive use, Text4-psychological and behavioral symptoms, iPod2-excessive use, and iPod3-relationship disruption were significant predictors of discounting. When texting dependence was the dependent variable, Text4-psychological and behavioral symptoms and iPod3-relationship disruption were significant predictors of discounting. These are the first data to show that delay discounting relates to certain aspects of social media, namely iPod and texting dependence. These data also show that across these 2 dependencies, both psychological and behavioral symptoms and relationship disruptions are affected.
The Evolution of the American Journal of Psychology, 1904-1918: A Network Investigation
Authors: Green Christopher D. , Feinerer Ingo
Published: May 2016

In an earlier article, we used digital historical methods to examine the first 14 volumes (1887- 1903) of The American Journal of Psychology (AJP ) by creating networks of the vocabularies used in every substantive article the journal published in those years. These networks showed us the major research groups that had been gathered together by the journal’s founder-editor, G. Stanley Hall, and how the intellectual composition of the journal (and the discipline) changed over that 17-year period. In the present article we extended that study forward, creating networks for the next 15 volumes (1904-1918), broken into time blocks of 5 years each. Our findings, in brief, were that vision research (especially color) continued to play as consistent and prominent role in the journal as it had since the start; that memory, association, and some higher mental processes were active areas of research throughout; that Hall continued to have an on-again, off-again relationship with theoretical and philosophical psychology; that intelligence-measuring methods, psychoanalysis, and psychophysics were periodically popular enough that they each generated a cluster in 1 of the 3 time blocks; and that Titchener’s participation in the editing of AJP led to its becoming the major outlet for his Structuralist research program (an absence that we noted in our earlier studies of the journal Psychological Review).
(Im)possible conversations? activism, childhood and everyday life
Authors: Nolas Sevasti-Melissa , Varvantakis Christos , Aruldoss Vinnarasan
Published: May 2016

The paper offers an analytical exploration and points of connection between the categories of activism, childhood and everyday life. We are concerned with the lived experiences of activism and childhood broadly defined and especially with the ways in which people become aware, access, orient themselves to, and act on issues of common concern; in other words what connects people to activism. The paper engages with childhood in particular because childhood remains resolutely excluded from practices of public life and because engaging with activism from the marginalized position of children’s everyday lives provides an opportunity to think about the everyday, lived experiences of activism. Occupying a space ‘before method’, the paper engages with autobiographical narratives of growing up in the Communist left in the USA and the historical events of occupying Greek schools in the 1990s. These recounted experiences offer an opportunity to disrupt powerful categories currently in circulation for thinking about activism and childhood. Based on the analysis it is argued that future research on the intersections of activism, childhood and everyday life would benefit from exploring the spatial and temporal dimension of activism, to make visible the unfolding biographical projects of activists and movements alike, while also engaging with the emotional configurations of activists’ lives and what matters to activists, children and adults alike.
ПРЕДНОСТИ И НЕДОСТАЦИ ТУРСКЕ У ПОКУШАЈУ ДА ПОСТАНЕ РЕГИОНАЛНА СИЛА
Authors: Петровић Драган
Published: May 2016

У раду се посматра савремена Турска која има евидентнеамбиције да постане јака регионална сила. Анализирају се њене предности инедостаци у том контексту, и то посебно елементи „тврде“ и „меке“ моћи, којизаправо указују на низ ограничења и недостатака на путу остварења таквихамбиција. Са друге стране Турска има и извесне предиспозиције које нису спорнеза одржавање свог утицаја у региону. Посебно се у раду анализирају односизваничне Србије и Турске последњих година. Док у економској сфери постојеизвесне могућности развоја сарадње, у политичкој сарадњи се препоручује опрез,посебно имајући у виду питање Косова и Метохије, али и укупан турскигеополитички однос према регији Балкана.
OSNOVNE FUNKCIJE SAVREMENE PORODICE
Authors: Vukoje Jovan
Published: May 2016

Porodica, kao osnovno jezgro prvih pedagoških impulsa, usljedsnažnih emocionalnih veza roditelja i djece, značajan je činilac u razvoju mlade ličnosti. Nazivi savremene porodice uslovljeni su dominacijom pedagoškog,psihološkog, pravnog ili sociološkog stanovišta. Porodično vaspitanje i uopšte porodični život u razvoju svakog djeteta predstavlja najvažniji stepen vaspitanja buduće društveno-kulturne ličnosti. Roditeljska uloga u toj porodici izuzetno je složena, jer seona prije svega ogleda kroz ljubav prema djetetu, brige o njemu.
RACIONALIZACIJA I BIROKRATIJA
Authors: Kovačević Irina
Published: May 2016

Marks je uzroke mnogih društvenih protivrječnosti, sukoba iantagonizama u društvu pronašao u načinu proizvodnje, klasnim sukobima, državi ipolitičkom uređenju društva da bi upravo na taj način i došao do određenja pojmabirokratije. Birokratija ne predstavlja ništa drugo do državni formalizam građanskogdruštva – ona je „državna svijest”, „državna volja” i „državna moć” koja štitiimaginarnu opštost posebnog društvenog interesa.Birokratija i proces birokratizacije predstavljaju za Vebera pravi primjerracionalizacije. Veber je isticao da se ljudi okreću od tradicionalnih vrijednosti koje suzasnovane na iracionalnosti, sentimentalnosti, tradiciji, praznovjerju, običajima, religijii krutim navikama i da se sve više okreću prema racionalnim, kalkulantskim,proračunatim, efikasnim i interesnim orijentacijama ličnog i društvenog djelovanja.Tako je tradicionalno predindustrijsko društvo ustupilo mjesto modernomindustrijskom društvu u kojem nema prostora za osjećanja, već za razvoj nauke,tehnologije i birokratske organizacije i upravljanja društvom. U osnovi razvoja novogdruštva nalazi se racionalizacija, odnosno organizacija društvenog života (ekonomskog,političkog, kulturnog) prema principima efikasnosti. Razvoj industrijskog kapitalizmasamo je potvrđivao ulogu racionalizacije u organizaciji ukupnog društvenog života. A,da bi taj razvoj mogao biti ostvaren, neophodna je visoko organizovana racionalnaorganizacija koju Veber pronalazi upravo u – birokratiji.
ОСИГУРАЊЕ ДЕПОЗИТА И МОРАЛНИ ХАЗАРД
Authors: Крунић Горана
Published: May 2016

Ефикасно успостављен систем осигурања депозита треба даобезбиједи заштиту депозита, да спријечи „бјежање“ депозита из банака, те дадопринесе одржању финансијске стабилности у једној економији. Међутим,постојање осигурања депозита може да проузрокује и негативне посљедице каошто су смањење интензитета дјеловања тржишне дисциплине, те јачањеморалног хазарда.Jасним дефинисањем фактора за ублажавање моралног хазарда ињиховим инкорпорирањем унутар одговарајуће регулативе обезбјеђује сесмањење степена дјеловања моралног хазарда и на тај начин доприноси сеостваривању постављених циљева јавне политике (у контексту осигурањадепозита испуњавање основних циљева јавне политике подразумјева заштитудепозита и допринос одржању финансијске стабилности).За израду овог рада коришћени су емпиријски налази еминентнихаутора из области осигурања депозита, међународних финансијских институцијакао што су Међународни Монетарни Фонд, Свјетска банка, Европска Централнабанка, водичи међународног удружења осигураватеља депозита, одговарајућеевропске и босанскохерцеговачке регулативе, те супервизијско и искуство изосигурања депозита аутора овог рада.
DRUŠTVENA ODGOVORNOST PREDUZEĆA U INDUSTRIJI TURIZMA U BOSNI I HERCEGOVINI
Authors: Čekrlija Saša , Pavlović Slobodanka
Published: May 2016

Cilj je da se uz istorijsku analizu i prikaz modela društvenoodgovornog poslovanja (DOP-a) koji prevladava u EU, empirijskim istraživanjem naograničenom uzorku preduzeća u BiH iz oblasti turizma i uslužnih djelatnosti ustanovikoliko upravljačke strukture preduzeća, u srazmjerno mladoj i slabo razvijenoj privredi,poznaju pojam, svrhu i politiku društvene odgovornosti preduzeća. Da li premanavednoj postavci postoji uključenost zaposlenih u formulisanju i primjeni modelaDOP-a. Svjesni činjenice da je koncept korporativnog upravljanja sve prisutniji umodernoj ekonomiji treba postaviti pitanje: koja je razumna cijena tehnološkeekspanzije i do koje granice je moguć ukupan rast? Do kojih granica se može kretatitolerancija uslova rada? Predmet istraživanja je društvena odgovornost preduzeća uBiH iz oblasti turizma i uslužnog sektora. Istraživanje je usmjereno na shvatanjevažnosti provođenja koncepta DOP-a i promocije dobre prakse te na stepen poštivanjamandatorne, odnosno fakultativne odgovornosti preduzeća i njihovu spremnost dazanemare iste ukoliko određene okolnosti takav potez nametnu kao kratkoročnorješenje. Područje istraživanja je poznavanje i primjena modela društveno odgovornogposlovanja određenog broja BiH preduzeća iz oblasti turizma i uslužnih djelatnosti, ali imenadžmenta koji tim preduzećima upravlja.
OSOBINE MLAZNOG GORIVA GM-1
Authors: Arsenović Božidarka , Janjuš Zoran
Published: May 2016

Toplota i brzina sagorijevanja mlaznog goriva umnogome zavisi odintenziteta procesa sagorijevanja u komorama sagorijevanja, a oni, sa svoje strane,zavise od kvaliteta goriva (viskoziteta, isparljivosti, hemijskog i frakcionog sastava).Savremeni mlazni motori koriste goriva tipa kerozina. Dalji razvoj kvaliteta gorivauslovljen je potrebama za sve većim nadzvučnim brzinama, kao i sve strožijimzahtjevima socijalno-ekološke prirode u pogledu kvaliteta izduvnih gasova iz motoraaviona. Perspektivna mlazna goriva biće više obogaćena aditivima, prvenstvenoantioksidantima, aditivima za poboljšanje termičke stabilnosti, stabilnosti tokomskladištenja kao i za poboljšanje mazivosti, kako bi se smanjilo habanje agregatagorivnih sistema. Deaeromatizovana goriva posjeduju povišen energetski koeficijent ivisoku termičku stabilnost na temperaturama do 2600C.
De novoassembly and characterization of the Chinese three-keeled pond turtle (Mauremys reevesii) transcriptome: presence of longevity-related genes
Authors: Yin Huazong , Nie Liuwang , Zhao Feifei , Zhou Huaxing , Li Haifeng , Dong Xianmei , Zhang Huanhuan , Wang Yuqin , Shi Qiong , Li Jun
Published: May 2016

Mauremys reevesii(Geoemydidae) is one of the most common and widespread semi-aquatic turtles in East Asia. The unusually long lifespan of some individuals makes this turtle species a potentially useful model organism for studying the molecular basis of longevity. In this study, pooled total RNA extracted from liver, spleen and skeletal-muscle of three adult individuals were sequenced using Illumina Hiseq 2500 platform. A set of telomere-related genes were found in the transcriptome, includingtert,tep1, and six shelterin complex proteins coding genes (trf1,trf2,tpp1, pot1, tin2andrap1). These genes products protect chromosome ends from deterioration and therefore significantly contribute to turtle longevity. The transcriptome data generated in this study provides a comprehensive reference for future molecular studies in the turtle.
DeepSNVMiner: a sequence analysis tool to detect emergent, rare mutations in subsets of cell populations
Authors: Andrews T. Daniel , Jeelall Yogesh , Talaulikar Dipti , Goodnow Christopher C. , Field Matthew A.
Published: May 2016

Background.Massively parallel sequencing technology is being used to sequence highly diverse populations of DNA such as that derived from heterogeneous cell mixtures containing both wild-type and disease-related states. At the core of such molecule tagging techniques is the tagging and identification of sequence reads derived from individual input DNA molecules, which must be first computationally disambiguated to generate read groups sharing common sequence tags, with each read group representing a single input DNA molecule. This disambiguation typically generates huge numbers of reads groups, each of which requires additional variant detection analysis steps to be run specific to each read group, thus representing a significant computational challenge. While sequencing technologies for producing these data are approaching maturity, the lack of available computational tools for analysing such heterogeneous sequence data represents an obstacle to the widespread adoption of this technology.

Results.Using synthetic data we successfully detect unique variants at dilution levels of 1 in a 1,000,000 molecules, and find DeeepSNVMiner obtains significantly lower false positive and false negative rates compared to popular variant callers GATK, SAMTools, FreeBayes and LoFreq, particularly as the variant concentration levels decrease. In a dilution series with genomic DNA from two cells lines, we find DeepSNVMiner identifies a known somatic variant when present at concentrations of only 1 in 1,000 molecules in the input material, the lowest concentration amongst all variant callers tested.

Conclusions.Here we present DeepSNVMiner; a tool to disambiguate tagged sequence groups and robustly identify sequence variants specific to subsets of starting DNA molecules that may indicate the presence of a disease. DeepSNVMiner is an automated workflow of custom sequence analysis utilities and open source tools able to differentiate somatic DNA variants from artefactual sequence variants that likely arose during DNA amplification. The workflow remains flexible such that it may be customised to variants of the data production protocol used, and supports reproducible analysis through detailed logging and reporting of results. DeepSNVMiner is available for academic non-commercial research purposes athttps://github.com/mattmattmattmatt/DeepSNVMiner.