bluuebunny/crossref_metadata_2025 huggingface dataset:
The Impact of Diffuse Idiopathic Skeletal Hyperostosis on Nutritional Status, Neurological Outcome, and Perioperative Complications in Patients with Cervical Spinal Cord Injury
Authors: Shimizu Tomoaki , Suda Kota , Harmon Satoko Matsumoto , Komatsu Miki , Ota Masahiro , Ushirozako Hiroki , Minami Akio , Takahata Masahiko , Iwasaki Norimasa , Takahashi Hiroshi , Yamazaki Masashi
Published: September 2023

This retrospective study aimed to investigate the characteristics of patients with cervical spinal cord injuries (CSCI) with diffuse idiopathic skeletal hyperostosis (DISH). We included 153 consecutive patients with CSCI who underwent posterior decompression and fusion surgery. The patients were divided into two groups based on the presence of DISH. Patient characteristics, neurological status on admission, nutritional status, perioperative laboratory variables, complications, neurological outcomes at discharge, and medical costs were compared between the groups. The DISH group (n = 24) had significantly older patients (72.1 vs. 65.9, p = 0.036), more patients with low-impact trauma (62.5% vs. 34.1%, p = 0.009), and a lower preoperative prognostic nutritional index on admission (39.8 vs. 42.5, p = 0.014) than the non-DISH group (n =129). Patients with DISH had significantly higher rates of ventilator management (16.7% vs. 3.1%, p = 0.022) and pneumonia (29.2% vs. 8.5%, p = 0.010). There was no significant difference in medical costs and neurological outcomes on discharge. Patients with CSCI and DISH were older, had poor nutritional status, and were prone to postoperative respiratory complications, while no differences were found between the neurological outcomes of patients with CSCI with and without DISH.
A Biopsychosocial Model Predicting Myocardial Infarction
Authors: Tomás José M. , Oliver Amparo , Torres Zaira , Parker Janhavi , Marques-Sule Elena , Sentandreu-Mañó Trinidad
Published: September 2023

Myocardial infarction is one of the main causes of death, and cardiovascular risk factors (CVRFs) are always considered when studying it. However, although it is known that other social and psychological variables, and especially frailty, can increase the risk of infarction, their simultaneous effect has not been extensively studied. This study is based on data from the SHARE project (latest wave, Wave 8), with a representative sample of 46,498 participants aged 50 or older (M = 70.40, SD = 9.33), of whom 57.4% were females. Statistical analyses included a full structural equation model that predicts 27% of infarction occurrence and evidences the significant effect of well-being, depression, and social connectedness on frailty. Frailty, in turn, explains 15.5% of the variability of CVRFs. This work supports the need to study these physical, social, and mental health factors together to intervene on frailty and, in turn, improve cardiovascular outcomes.
Conservative Treatment and Surgical Indication of Cervical Ossification of the Posterior Longitudinal Ligament
Authors: Furuya Takeo , Sakai Kenichiro , Yoshii Toshitaka , Machino Masaaki
Published: September 2023

Ossification of the posterior longitudinal ligament (OPLL) sometimes causes severe myelopathy and requires surgical treatment [...]
Acute-Onset Retinal Conditions Mimicking Acute Optic Neuritis: Overview and Differential Diagnosis
Authors: Interlandi Emanuela , Pellegrini Francesco , Giuffrè Chiara , Cirone Daniele , Brocca Daniele , Lee Andrew G. , Casalino Giuseppe
Published: September 2023

Acute optic neuritis (AON) is a common cause of sudden visual loss in young patients. Because of the risk of demyelinating disease, patients affected by unilateral or bilateral optic neuritis should be evaluated and treated accordingly. Despite advancements in imaging of the brain and retina, misdiagnosis of AON is not uncommon. Indeed, some acute disorders of the retina have the potential to mimic AON and their prompt diagnosis may avoid unnecessary neurologic investigation, psychological stress to the patient, and delays in treatment. This review describes uncommon retinal disorders presenting with sudden-onset visual loss and absent or subtle funduscopic manifestation that can mimic AON. Multimodal retinal imaging is essential in detecting these conditions and in their differential diagnosis. It behooves neurologists and general ophthalmologists to be aware of these entities and be familiar with multimodal imaging of the retina.
A History of COVID-19 in Pregnancy: A Narrative Review
Authors: Chaudhry Shahrukh , Aboudawoud Omar , Hardy Ghislain
Published: September 2023

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread across the world causing a global pandemic. During a pandemic, it becomes increasing important to evaluate the effects on specific populations at risk. In this narrative review, we analyzed the literature regarding COVID-19 infection on the pregnant population as they are at increased risk of infection. COVID-19 did seem to significantly increase the risk of obstetric complications, specifically in underserved and marginalized populations. In general, COVID-19 rarely directly infected the fetus and placenta, apart from a very rare complication called COVID placentitis. In actuality, the mothers were at greatest direct risk due to COVID-19 infection. The most important takeaway from this pandemic is the prospective lesson and effect it had on social determinants of health. Women did not have safe access to antenatal care, leading to a plethora of indirect obstetric complications due to COVID-19. In conclusion, it was women who suffered from the pandemic, not the placenta nor the fetus. It is our duty as physicians to protect pregnant women, allowing the placenta to protect the fetus.
Catecholamine Derivatives as Novel Crosslinkers for the Synthesis of Versatile Biopolymers
Authors: Sugumaran Manickam , Evans Jason J.
Published: September 2023

Catecholamine metabolites are not only involved in primary metabolism, but also in secondary metabolism, serving a diverse array of physiologically and biochemically important functions. Melanin, which originates from dopa and dopamine, found in the hair, eye, and skin of all animals, is an important biopolymeric pigment. It provides protection against damaging solar radiation to animals. N-Acetyldopamine and N-β-alanyldopamine play a crucial role in the hardening of the exoskeletons of all insects. In addition, insects and other arthropods utilize the melanogenic process as a key component of their defense systems. Many marine organisms utilize dopyl peptides and proteins as bonding materials to adhere to various substrata. Moreover, the complex dopa derivatives that are precursors to the formation of the exoskeletons of numerous marine organisms also exhibit antibiotic properties. The biochemistry and mechanistic transformations of different catecholamine derivatives to produce various biomaterials with antioxidant, antibiotic, crosslinking, and gluing capabilities are highlighted. These reactivities are exhibited through the transient and highly reactive quinones, quinone methides, and quinone methide imine amide intermediates, as well as chelation to metal ions. A careful consideration of the reactivities summarized in this review will inspire numerous strategies for synthesizing novel biomaterials for future medical and industrial use.
A Sustainable, Green-Processed, Ag-Nanoparticle-Incorporated Eggshell-Derived Biomaterial for Wound-Healing Applications
Authors: Mensah Rosemond A. , Trotta Federico , Briggs Emily , Sharifulden Nik San , Silva Lady V. Barrios , Keskin-Erdogan Zalike , Diop Seyta , Kureshi Alvena K. , Chau David Y. S.
Published: September 2023

The eggshell membrane (ESM) is a natural biomaterial with unique physical and mechanical properties that make it a promising candidate for wound-healing applications. However, the ESM’s inherent properties can be enhanced through incorporation of silver nanoparticles (AgNPs), which have been shown to have antimicrobial properties. In this study, commercially produced AgNPs and green-processed AgNPs were incorporated into ESM and evaluated for their physical, biological, and antimicrobial properties for potential dermal application. The ESM was extracted using various techniques, and then treated with either commercially produced AgNPs (Sigma-Aldrich, Poole, UK) or green-synthesized AgNPs (Metalchemy, London, UK) to produce AgNPs-ESM samples. The physical characteristics of the samples were evaluated using scanning electron microscopy (SEM), Fourier Transform Infrared (FTIR) spectroscopy, and the biological properties were assessed through in vitro studies using human dermal fibroblasts (HDFs) and BJ cells. The SEM analysis of the AgNPs-ESM samples showed localization of AgNPs on the ESM surface, and that the ESM maintained its structural integrity following AgNP incorporation. The FTIR confirmed loading of AgNPs to ESM samples. The biological studies showed that the 5 μg/mL AgNPs-ESM samples were highly biocompatible with both HDFs and BJ cells, and had good viability and proliferation rates. Additionally, the AgNPs-ESM samples demonstrated pro-angiogenic properties in the CAM assay, indicating their potential for promoting new blood vessel growth. Assessment of the antimicrobial activity of the enhanced AgNPs/ESMs was validated using the International Standard ISO 16869:2008 methodology and exploited Cladosporium, which is one of the most commonly identified fungi in wounds, as the test microorganism (≥5 × 106 cells/mL). The AgNPs-ESM samples displayed promising antimicrobial efficacy as evidenced by the measured zone of inhibition. Notably, the green-synthesized AgNPs demonstrated greater zones of inhibition (~17 times larger) compared to commercially available AgNPs (Sigma-Aldrich). Although both types of AgNP exhibited long-term stability, the Metalchemy-modified samples demonstrated a slightly stronger inhibitory effect. Overall, the AgNPs-ESM samples developed in this study exhibited desirable physical, biological, and antimicrobial properties for potential dermal wound-dressing applications. The use of green-processed AgNPs in the fabrication of the AgNPs-ESM samples highlights the potential for sustainable and environmentally friendly wound-healing therapies. Further research is required to assess the long-term biocompatibility and effectiveness of these biomaterials in vivo.
Bilosomes as Nanocarriers for the Drug and Vaccine Delivery against Gastrointestinal Infections: Opportunities and Challenges
Authors: Zarenezhad Elham , Marzi Mahrokh , Abdulabbas Hussein T. , Jasim Saade Abdalkareem , Kouhpayeh Seyed Amin , Barbaresi Silvia , Ahmadi Shiva , Ghasemian Abdolmajid
Published: September 2023

The gastrointestinal tract (GIT) environment has an intricate and complex nature, limiting drugs’ stability, oral bioavailability, and adsorption. Additionally, due to the drugs’ toxicity and side effects, renders are continuously seeking novel delivery systems. Lipid-based drug delivery vesicles have shown various loading capacities and high stability levels within the GIT. Indeed, most vesicular platforms fail to efficiently deliver drugs toward this route. Notably, the stability of vesicular constructs is different based on the different ingredients added. A low GIT stability of liposomes and niosomes and a low loading capacity of exosomes in drug delivery have been described in the literature. Bilosomes are nonionic, amphiphilic, flexible surfactant vehicles that contain bile salts for the improvement of drug and vaccine delivery. The bilosomes’ stability and plasticity in the GIT facilitate the efficient carriage of drugs (such as antimicrobial, antiparasitic, and antifungal drugs), vaccines, and bioactive compounds to treat infectious agents. Considering the intricate and harsh nature of the GIT, bilosomal formulations of oral substances have a remarkably enhanced delivery efficiency, overcoming these conditions. This review aimed to evaluate the potential of bilosomes as drug delivery platforms for antimicrobial, antiviral, antifungal, and antiparasitic GIT-associated drugs and vaccines.
Eye Movement Reflexes Indicate the Homing Direction in the Path-Integrating Fiddler Crab, Uca pugilator
Authors: Chatterji Ruma , Layne John E.
Published: September 2023

As animals execute essential behaviors like foraging, they must orient with respect to the space around them, requiring some neural/behavioral mechanism for spatial navigation. One such navigation mechanism is path integration, whereby animals recall their starting point by creating a memory-stored home vector. In some animals, this is stored in an egocentric frame of reference; however, it remains unclear what comprises this in animals’ spatial memory. The fiddler crab Uca pugilator makes an excellent model to investigate the nature of the egocentric frame of reference because they appear to path integrate using self-motion cues to form an egocentric vector. We hypothesized that the home vector direction is governed by the optokinetic system, since the eye–body angle explicitly reflects the deviation of the body axis from home direction as optokinetic eye movements stabilize the eyes against body rotation. To test this hypothesis, we monitored eye and body movements during foraging excursions of crabs showing varying degrees of visual stabilization. We found that crabs with good eye stability had more accurate home vectors than those with poor eye stability, and the quantitative degree of stability accurately predicted the crabs’ perception of home direction. These results suggest that eye movement reflexes may establish the homing direction in path integrating fiddler crabs.
Design and Process Planning of Non-Structured Surface Spray Equipment for Ultra-Large Spaces in Ship Section Manufacturing
Authors: Qie Jinbo , Miao Yugang , Liu Huiju , Han Tao , Shao Zhufeng , Duan Jinhao
Published: September 2023

Sandblasting and coating constitute a critical phase in ship manufacturing, a process currently predominantly reliant on manual labor. To enhance the efficiency and quality of the coating process for shipbuilding segments, to address the challenges shipbuilding companies face in labor recruitment and shortage, and to simultaneously elevate the level of intelligent manufacturing for ship segment coating, this research investigates equipment suitable for large-scale, non-structural surface coating in shipbuilding segments, considering the unique features of ship segments and the customary techniques employed by shipbuilding companies. The structure, size parameters, and principal components of the coating equipment are determined. Regular workspace with high performance is designated and the coating process is planned based on the working environment and the curvature characteristics of the surface to be coated. The results demonstrate that the proposed coating equipment improved efficiency by 300% compared to manual painting, providing a novel automated solution for the coating of ship segments.
Evolution of Scour Length around Circular Piles Subjected to Irregular Waves Due to Climate Change
Authors: Arjona-Catzim Iván F. , Ocaña-E. de los Monteros Karina , Horta-Rangel Jaime M. , Ávila-Arzani Dora L. , Hernández-Zaragoza Juan B. , López-Lara Teresa , Rojas-González Eduardo
Published: September 2023

Scour is a phenomenon that affects structures deployed in rivers or seas, favoring the transport of sediments around their foundations, which can expose their structural stability. This work aimed to develop a physical model of a mobile bottom to determine the scour-hole extensions around a group of four vertical piles of circular sections subjected to irregular waves. For this purpose, a beach profile and a typical slope were constructed and subjected to 24 h of storm waves, divided into 12 h intervals in the prototype. Additionally, three wave periods were studied according to the Mexican Institute of Transportation wave data and three scenarios of a rise in sea level. The data suggest that the length of the scour hole was greater in the piles in the front for all cases, which may be reflected in a reduction in scour protection costs. The results obtained for the extent of the scour hole suggest a setting of less than four times the pile diameter in most cases. Finally, it is inferred that a rise in sea level by itself is not a decisive factor in the increase in the values obtained; therefore, it is necessary to consider the variations in wave heights and wave periods associated with such increases.
Green Hydrogen Production and Its Land Tenure Consequences in Africa: An Interpretive Review
Authors: Chigbu Uchendu Eugene , Nweke-Eze Chigozie
Published: September 2023

Globally, a green hydrogen economy rush is underway, and many companies, investors, governments, and environmentalists consider it as an energy source that could foster the global energy transition. The enormous potential for hydrogen production, for domestic use and export, places Africa in the spotlight in the green hydrogen economy discourse. This discourse remains unsettled regarding how natural resources, such as land and water, can be sustainably utilized for such a resource-intensive project, and what implications this would have. This review argues that green hydrogen production (GHP) in Africa has consequences where land resources (and their associated natural resources) are concerned. It discusses the current trends in GHP in Africa, and the possibilities for reducing any potential pressures it may put on land and other resource use on the continent. The approach of the review is interpretive, and hinges on answering three questions, concerning the what, why, and how of GHP and its land consequences in Africa. The review is based on 41 studies identified from Google Scholar, and sources identified via snowballed recommendations from experts. The GHP implications identified relate to land and water use, mining-related land stress, and environmental, ecological, and land-related socioeconomic consequences. The paper concludes that GHP may not foster the global energy transition, as is being opined by many renewable energy enthusiasts but, rather, could help foster this transition as part of a greener energy mix. It notes that African countries that have the potential for GHP require the institutionalization of, or a change in, their existing approaches to land-related energy governance systems, in order to achieve success.
Approaches to Minimise the Neurodevelopmental Impact of Choroid Plexus Carcinoma and Its Treatment
Authors: Adamski Jenny , Langford Vikki , Finlay Jonathan L.
Published: September 2023

Choroid plexus carcinomas (CPC) are rare aggressive tumours that primarily affect very young children. Treatment for CPC typically involves a combination of surgery, chemotherapy, and radiation therapy. Whilst considered necessary for a cure, these therapies have significant neurocognitive consequences for patients, negatively impacting cognitive function including memory, attention, executive functioning, and full-scale intelligence quotients (FSIQ). These challenges significantly impact the quality of life and ultimately socioeconomic parameters such as the level of educational attainment, marital status, and socioeconomic status. This review looks at the tumour- and treatment-related causes of neurocognitive damage in CPC patients and the progress made in finding strategies to reduce these. Opportunities to mitigate the neurodevelopmental consequences of surgery, chemotherapy, and radiation therapy are explored in the context of CPC treatment. Evaluation of the pathological and biological mechanisms of injury has identified innovative approaches to neurocognitive protection and neurorehabilitation, which aim to limit the neurocognitive damage. This review aims to highlight multiple approaches physicians can use when treating young children with CPC, to focus on neurocognitive outcomes as a measure of success.
FEM Simulations of Fatigue Crack Initiation in the Oligocrystalline Microstructure of Stents
Authors: Lasko Galina , Schmauder Siegfried , Yang Yitong , Weiss Sabine , Dogahe Kiarash
Published: September 2023

For over two decades, vascular stents have been widely used to treat clogged vessels, serving as a scaffold to enlarge the narrowed lumen and recover the arterial flow area. High-purity oligocrystalline austenitic steel is usually applied for the production of stents. Despite the popularity and benefit of stenting, it still may cause serious clinical adverse issues, such as in-stent restenosis and stent fracture. Therefore, the study of the mechanical properties of stents and in particular the prediction of their life cycles are in the focus of materials research. In our contribution, within the finite element method, a two-scale model of crack initiation in the microstructure of stents is elaborated. The approach is developed on the basis of the physically based Tanaka–Mura model (TMM), considering the evolution of shear bands during the crack initiation phase. The model allows for the analysis of the microstructure with respect to the life cycles of real materials. The effects of different loading conditions, grain orientation, and thickness of the specimen on Wöhler curves were analysed. It was found that the microstructural features of oligocrystals are very sensitive to different loading conditions with respect to their fatigue behaviour and play a major role in fatigue crack initiation. Different grain-orientation distributions result in qualitative and quantitative differences in stress distribution and in the number of cycles for crack initiation. It was found that presence of a neutral zone in the cut-out of the microstructure under three-point-bending loading conditions changes the qualitative and quantitative patterns of stress distribution and affects the number of cycles for crack initiation. It was found that under both tensile and bending loading conditions, thicker specimens require more cycles for crack initiation. The Wöhler curves for crack initiation in oligocrystalline microstructures of stents could be compared with the ones in the experiment, taking into account that for high cyclic fatigue (HCF), typically, more than 70% of the cycles refer to crack initiation. The developed numerical tools could be used for the material design of stents.
Molecular Mechanism of the Piezoelectric Response in the β-Phase PVDF Crystals Interpreted by Periodic Boundary Conditions DFT Calculations
Authors: Serra Gianluca , Arrigoni Alessia , Del Zoppo Mirella , Castiglioni Chiara , Tommasini Matteo
Published: September 2023

A theoretical approach based on Periodic Boundary Conditions (PBC) and a Linear Combination of Atomic Orbitals (LCAO) in the framework of the density functional theory (DFT) is used to investigate the molecular mechanism that rules the piezoelectric behavior of poly(vinylidene fluoride) (PVDF) polymer in the crystalline β-phase. We present several computational tests highlighting the peculiar electrostatic potential energy landscape the polymer chains feel when they change their orientation by a rigid rotation in the lattice cell. We demonstrate that a rotation of the permanent dipole through chain rotation has a rather low energy cost and leads to a lattice relaxation. This justifies the macroscopic strain observed when the material is subjected to an electric field. Moreover, we investigate the effect on the molecular geometry of the expansion of the lattice parameters in the (a, b) plane, proving that the rotation of the dipole can take place spontaneously under mechanical deformation. By band deconvolution of the IR and Raman spectra of a PVDF film with a high content of β-phase, we provide the experimental phonon wavenumbers and relative band intensities, which we compare against the predictions from DFT calculations. This analysis shows the reliability of the LCAO approach, as implemented in the CRYSTAL software, for calculating the vibrational spectra. Finally, we investigate how the IR/Raman spectra evolve as a function of inter-chain distance, moving towards the isolated chain limit and to the limit of a single crystal slab. The results show the relevance of the inter-molecular interactions on the vibrational dynamics and on the electro-optical features ruling the intensity pattern of the vibrational spectra.
Color Tunable Composite Phosphor Ceramics Based on SrAlSiN3:Eu2+/Lu3Al5O12:Ce3+ for High-Power and High-Color-Rendering-Index White LEDs/LDs Lighting
Authors: Ye Shenrui , Li Yukun , Qiang Ming , Lou Wenhui , Dai Bo , Lin Hui , Han Zhaoxia , Hong Ruijin , Zhang Dawei
Published: September 2023

Lu3Al5O12:Ce3+ phosphor ceramics were fabricated by vacuum sintering. On this basis, a bi-layer composite phosphor was prepared by low-temperature sintering to cover the phosphor ceramics with a layer of SrAlSiN3:Eu2+-phosphor-in-glass (PiG). The optical, thermal, and colorimetric properties of LuAG:Ce3+ phosphor ceramics, SrAlSiN3:Eu2+ phosphors and SrAlSiN3:Eu2+-PiG were studied individually. Combining the bi-layer composite phosphors with the blue LED chip, it is found that the spectrum can be adjusted by varying the doping concentration of SrAlSiN3:Eu2+-PiG and the thickness of Lu3Al5O12:Ce3+ phosphor ceramics. The maximal color rendering index value of the white LED is 86, and the R9 is 61. Under the excitation of a laser diode, the maximum phosphor conversion efficacy of the bi-layer composite phosphors is 120 lm/W, the Ra is 83, and the correlated color temperature is 4534 K. These results show that the bi-layer composite phosphor ceramic is a candidate material to achieve high color rendering index for high brightness lighting.
Deflection Intelligent Prediction for High-Strength Steel Saddle Plate Forming Applicable to Reducing Ship Weight
Authors: Wang Shun , Dai Jinliang , Xu Zhikang , Wang Ji , Li Rui , Wang Jiayan
Published: September 2023

The application of high-strength steel plates can reduce ship weight, and the saddle plate is one of the most common types of double-curved hull plates. To fill the research gap regarding high-strength steel saddle plates, two prediction models are established here to predict deformation in saddle plate forming. Deflection is a key parameter reflecting the overall deformation of a curved plate. Therefore, first of all, the influencing factors of the line heating of high-strength steel saddle plates were analyzed. The influence of plate geometric parameters and forming parameters on deflection was researched. Second, a multiple linear regression model between deflection and the geometric parameters and forming parameters of high-strength steel saddle plates was established. Finally, to solve the problem of a large error in the multivariate regression model for extrapolation, an intelligent prediction program for deflection based on a support vector machine (SVM) was developed using the Python language. The results show that the error of the multiple regression model was less than 5% for data interpolation. The error of the intelligent prediction model for deflection was less than 5% for data extrapolation. This research can provide data support for the automatic forming of marine saddle plates.
Effect of Aluminium Substitution on Physical Adsorption of Chloride and Sulphate Ions in Cement-Based Materials
Authors: Zhang Guangtai , Li Maoquan , Zhu Zheyu
Published: September 2023

When aluminium-rich phase minerals are added to Portland cement, Al atoms will enter the C-S-H and Al, then a substitution reaction will occur, forming a hydrated silica-calcium aluminate (C-A-S-H), which changes the molecular structure of the cement material. Due to limitations in experimental methods, the research on the bonding effect between corroded ions and Al-substituted structures is still unclear. Here, the mechanism of an Al substitution reaction affecting the adsorption of chloride and sulphate ions was studied using simulation. The C-A-S-H model of aluminium random substitution was built, evaluating the binding effects among the C-A-S-H, and sulphate and chloride ions. The results demonstrated that the C-A-S-H structure generated by the Al substitution reaction increased the physical adsorption capacity of the chloride and sulphate ions. The adsorption capacity of the sulphate ions was 13.26% higher than that before the Al substitution, and the adsorption capacity of chloride ions was 21.32% higher than that before the Al substitution. The addition of high aluminium phase minerals caused the interfacial flocculants C-A-S-H and C-S-H to connect and intertwine in the the interface transition zone (ITZ) structure. The addition of high-alumina phase minerals improves the microstructure of concrete hydration products, improving the physical and mechanical properties and durability of concrete. After the addition of 20% lithium slag, the sulphate ion erosion content and the chloride ion erosion content of the concrete decreased by 13.65% and 15.72%, respectively. This paper provides a deeper understanding of the effect of high-alumina phase admixtures on concrete at the micro-scale.
Enhancing the Security and Privacy in the IoT Supply Chain Using Blockchain and Federated Learning with Trusted Execution Environment
Authors: Zhu Linkai , Hu Shanwen , Zhu Xiaolian , Meng Changpu , Huang Maoyi
Published: September 2023

Federated learning has emerged as a promising technique for the Internet of Things (IoT) in various domains, including supply chain management. It enables IoT devices to collaboratively learn without exposing their raw data, ensuring data privacy. However, federated learning faces the threats of local data tampering and upload process attacks. This paper proposes an innovative framework that leverages Trusted Execution Environment (TEE) and blockchain technology to address the data security and privacy challenges in federated learning for IoT supply chain management. Our framework achieves the security of local data computation and the tampering resistance of data update uploads using TEE and the blockchain. We adopt Intel Software Guard Extensions (SGXs) as the specific implementation of TEE, which can guarantee the secure execution of local models on SGX-enabled processors. We also use consortium blockchain technology to build a verification network and consensus mechanism, ensuring the security and tamper resistance of the data upload and aggregation process. Finally, each cluster can obtain the aggregated parameters from the blockchain. To evaluate the performance of our proposed framework, we conducted several experiments with different numbers of participants and different datasets and validated the effectiveness of our scheme. We tested the final global model obtained from federated training on a test dataset and found that increasing both the number of iterations and the number of participants improves its accuracy. For instance, it reaches 94% accuracy with one participant and five iterations and 98.5% accuracy with ten participants and thirty iterations.
Nanocomposite Polymer Gel Electrolyte Based on TiO2 Nanoparticles for Lithium Batteries
Authors: Slesarenko Nikita A. , Chernyak Alexander V. , Khatmullina Kyunsylu G. , Baymuratova Guzaliya R. , Yudina Alena V. , Tulibaeva Galiya Z. , Shestakov Alexander F. , Volkov Vitaly I. , Yarmolenko Olga V.
Published: September 2023

In this article, the specific features of competitive ionic and molecular transport in nanocomposite systems based on network membranes synthesized by radical polymerization of polyethylene glycol diacrylate in the presence of LiBF4, 1-ethyl-3-methylimidazolium tetrafluoroborate, ethylene carbonate (EC), and TiO2 nanopowder (d~21 nm) were studied for 1H, 7Li, 11B, 13C, and 19F nuclei using NMR. The membranes obtained were studied through electrochemical impedance, IR-Fourier spectroscopy, DSC, and TGA. The ionic conductivity of the membranes was up to 4.8 m Scm−1 at room temperature. The operating temperature range was from −40 to 100 °C. Two types of molecular and ionic transport (fast and slow) have been detected by pulsed field gradient NMR. From quantum chemical modeling, it follows that the difficulty of lithium transport is due to the strong chemisorption of BF4– anions with counterions on the surface of TiO2 nanoparticles. The theoretical conclusion about the need to increase the proportion of EC in order to reduce the influence of this effect was confirmed by an experimental study of a system with 4 moles of EC. It has been shown that this approach leads to an increase in lithium conductivity in an ionic liquid medium, which is important for the development of thermostable nanocomposite electrolytes for Li//LiFePO4 batteries with a base of lithium salts and aprotonic imidasolium ionic liquid.
Creep Behavior and Deformation Mechanism of a Third-Generation Single Crystal Ni-Based Superalloy at 980 °C
Authors: Xu Ruida , Li Ying , Yu Huichen
Published: September 2023

As the primary choice for aero-engine turbine blades, creep resistance is an important mechanical property for the developing third-generation single crystal Ni-based superalloys. The creep behavior of the superalloy in the [001] orientation was studied at 980 °C under a series of stress levels, accompanied with scanning electron microscope (SEM) and transmission electron microscope (TEM) observation to investigate the microstructure and deformation mechanism. The deformation mechanism of the alloy is found to be dislocation gliding, propagating and forming a dislocation network in the γ/γ′ interface. Dislocation networks could hinder the movement of dislocation and decrease the creep rate to a constant during the steady-creep stage. The formation of dislocation networks was analyzed due to the interaction of <110> {111} dislocations. Then dislocations cut into γ′ phases as individual <110> super-dislocations, anti-phase boundary dislocation pairs, and stacking faults. The <110> super-dislocation in the γ′ phase may cross-slip into the {001} plane from the {111} plane to form Kear–Wilsdorf locks, which could inhibit dislocations from gliding or cross-slipping and then enhance the creep resistance.
Influence of the Manufacturing Process on the Corrosion and Mechanical Behavior of Esophageal Stents
Authors: Alferi Dino , Fojt Jaroslav , Kristianova Eva , Edwards Derek W. , Laasch Hans-Ulrich
Published: September 2023

Esophageal nitinol stents are an established method for treating swallowing difficulties caused by obstructing cancer. This raesearch investigates the influence of different qualities of raw metal alloys in combination with production technology on corrosion resistance in standardized simulated gastric fluid (SGF). Four different international stent manufacturers produced samples of their standard stents from nitinol sourced from three different alloy manufacturers. The stents were subjected to a 6-week immersion in SGF. During the immersion, the surface was studied at specified intervals using microscopy. The surface of the samples was also studied by X-ray Photoelectron Spectroscopy and after immersion the released ions were analyzed. Results demonstrated that both raw material and certain steps in the manufacturing process negatively affect corrosion resistance. Analysis of the SGF showed that the amount of nickel released is proportional to the degree of corrosion attack. Finally, current accepted standard test methods are inadequate for assessing susceptibility to corrosion by gastric acid and should take the low pH of the implanted environment into account. Conversely, certain measures in the manufacturing process are able to reduce the impact of the base material on corrosion susceptibility.
Novel Powder Feedstock towards Microstructure Engineering in Laser Powder Bed Fusion: A Case Study on Duplex/Super Duplex and Austenitic Stainless-Steel Alloys
Authors: Gargalis Leonidas , Karavias Leonidas , Graff Joachim S. , Diplas Spyros , Koumoulos Elias P. , Karaxi Evangelia K.
Published: September 2023

Additive manufacturing of Duplex Stainless Steels (DSS) and Super Duplex Stainless Steels (SDSS) has been successfully demonstrated using LPBF in recent years, however, both alloys feature an almost fully ferritic microstructure in the as-built condition due to the fast cooling rates associated with the Laser Powder Bed Fusion (LPBF) process. Blends of DSS and SDSS powders were formulated with austenitic stainless-steel 316L powder, aiming to achieve increased austenite formation during in the LPBF as-built condition to potentially minimize the post heat treatments (solution annealing and quenching). Powder characteristics were investigated and process parameters were optimized to produce near fully dense parts. Nanoindentation (NI) tests were conducted to measure, not only the local mechanical properties and correlate them with the as-built microstructure, but also to gain a deeper understanding in the deformation behavior of individual phases that cannot be studied directly by macroscopic tensile tests. Scanning Electron Microscopy (SEM) and Electron Backscatter Diffraction (EBSD) were employed for microstructural analysis and phase quantification. The microstructural analysis and EBSD phase maps revealed an increase in austenite in the as-built microstructures. Blend 1 resulted in a duplex microstructure consisting of 10% austenite at the XY plane and 20% austenite at the XZ plane. The austenite content increased with increasing proportion of 316L stainless steel in the powder blends. The DSS blend required a much higher volumetric energy density for the fabrication of near fully dense parts. This imposed a slower solidification and a higher melt pool homogeneity, allowing for adequate diffusion of the austenite stabilizing elements. The presented workflow and findings from this study provide valuable insights into powder mixing for the development of custom alloys for rapid material screening in LPBF.
Metabolite Alterations in Autoimmune Diseases: A Systematic Review of Metabolomics Studies
Authors: Mujalli Abdulrahman , Farrash Wesam F. , Alghamdi Kawthar S. , Obaid Ahmad A.
Published: September 2023

Autoimmune diseases, characterized by the immune system’s loss of self-tolerance, lack definitive diagnostic tests, necessitating the search for reliable biomarkers. This systematic review aims to identify common metabolite changes across multiple autoimmune diseases. Following PRISMA guidelines, we conducted a systematic literature review by searching MEDLINE, ScienceDirect, Google Scholar, PubMed, and Scopus (Elsevier) using keywords “Metabolomics”, “Autoimmune diseases”, and “Metabolic changes”. Articles published in English up to March 2023 were included without a specific start date filter. Among 257 studies searched, 88 full-text articles met the inclusion criteria. The included articles were categorized based on analyzed biological fluids: 33 on serum, 21 on plasma, 15 on feces, 7 on urine, and 12 on other biological fluids. Each study presented different metabolites with indications of up-regulation or down-regulation when available. The current study’s findings suggest that amino acid metabolism may serve as a diagnostic biomarker for autoimmune diseases, particularly in systemic lupus erythematosus (SLE), multiple sclerosis (MS), and Crohn’s disease (CD). While other metabolic alterations were reported, it implies that autoimmune disorders trigger multi-metabolite changes rather than singular alterations. These shifts could be consequential outcomes of autoimmune disorders, representing a more complex interplay. Further studies are needed to validate the metabolomics findings associated with autoimmune diseases.
Triazoles as a Potential Threat to the Nutritional Quality of Tomato Fruits
Authors: Hýsková Veronika , Jakl Michal , Jaklová Dytrtová Jana , Ćavar Zeljković Sanja , Vrobel Ondřej , Bělonožníková Kateřina , Kavan Daniel , Křížek Tomáš , Šimonová Alice , Vašková Marie , Kovač Ishak , Račko Žufić Antoniana , Ryšlavá Helena
Published: September 2023

Triazole fungicides can threaten plants as abiotic stressors but can also positively affect plant defense by inducing priming. Thus, plant yield is also both protected and endangered by triazoles that may influence several metabolic pathways during maturation processes, such as the biosynthesis of saccharides or secondary metabolites. Here, Solanum lycopersicum L. plants were exposed to foliar and soil applications of penconazole, tebuconazole, or their combination, and their resulting effect on tomato fruits was followed. The exposure to the equimolar mixture of both triazoles influenced the representation of free proteinogenic amino acids, especially Gln, Glu, Gly, Ile, Lys, Ser and Pro, saccharide content, and led to a significant increase in the contents of total phenolics and flavonoids as well as positive stimulation of the non-enzymatic antioxidant system. Among the identified secondary metabolites, the most abundant was naringenin, followed by chlorogenic acid in tomato peel. In turn, all triazole-treated groups showed a significantly lower content of rosmarinic acid in comparison with the control. Foliar application of penconazole affected the fruit more than other single triazole applications, showing a significant decrease in antioxidant capacity, the total content of secondary metabolites, and the activities of total membrane-bound peroxidases and ascorbate peroxidase.
Design Guidelines for Thin Diaphragm-Based Microsystems through Comprehensive Numerical and Analytical Studies
Authors: Belwanshi Vinod , Rane Kedarnath , Kumar Vibhor , Pramanick Bidhan
Published: September 2023

This paper presents comprehensive guidelines for the design and analysis of a thin diaphragm that is used in a variety of microsystems, including microphones and pressure sensors. It highlights the empirical relations that can be utilized for the design of thin diaphragm-based microsystems (TDMS). Design guidelines developed through a Finite Element Analysis (FEA) limit the iterative efforts to fabricate TDMS. These design guidelines are validated analytically, with the assumption that the material properties are isotropic, and the deviation from anisotropic material is calculated. In the FEA simulations, a large deflection theory is taken into account to incorporate nonlinearity, such that a critical dimensional ratio of a/h or 2r/h can be decided to have the linear response of a thin diaphragm. The observed differences of 12% in the deflection and 13% in the induced stresses from the analytical calculations are attributed to the anisotropic material consideration in the FEA model. It suggests that, up to a critical ratio (a/h or 2r/h), the thin diaphragm shows a linear relationship with a high sensitivity. The study also presents a few empirical relations to finalize the geometrical parameters of the thin diaphragm in terms of its edge length or radius and thickness. Utilizing the critical ratio calculated in the static FEA analysis, the basic conventional geometries are considered for harmonic analyses to understand the frequency response of the thin diaphragms, which is a primary sensing element for microphone applications and many more. This work provides a solution to microelectromechanical system (MEMS) developers for reducing cost and time while conceptualizing TDMS designs.
Understanding and Implementing Diagnostic Stewardship: A Guide for Resident Physicians in the Era of Antimicrobial Resistance
Authors: Schinas Georgios , Dimopoulos George , Akinosoglou Karolina
Published: September 2023

Antimicrobial resistance (AMR) poses a significant global health challenge, exacerbated by the COVID-19 pandemic. Antimicrobial stewardship programs (ASPs) are crucial in managing this crisis, with diagnostic stewardship (DS) emerging as a key component. DS refers to the appropriate use of diagnostic tests to optimize patient outcomes, improve antimicrobial use, and combat multi-drug-resistant (MDR) organisms. Despite its potential, understanding and application of DS remain ambiguous in multiple respects, which, however, do not directly implicate the implementation of such initiatives. DS is particularly important for resident physicians who are often at the forefront of patient care and can significantly influence future AMR strategies. This review provides a comprehensive overview of DS, discussing its importance, potential challenges, and future directions. It emphasizes the need for resident physicians to understand DS principles and integrate them into their clinical practice from the beginning of their careers. The review also highlights the role of various stakeholders in implementing DS and the importance of continuous education and training. Ultimately, DS is not just a clinical tool but a philosophy of care, essential for a more responsive, humane, and effective healthcare system.
A Comprehensive Review for the Surveillance of Human Pathogenic Microorganisms in Shellfish
Authors: Desdouits Marion , Reynaud Yann , Philippe Cécile , Guyader Françoise S. Le
Published: September 2023

Bivalve molluscan shellfish have been consumed for centuries. Being filter feeders, they may bioaccumulate some microorganisms present in coastal water, either naturally or through the discharge of human or animal sewage. Despite regulations set up to avoid microbiological contamination in shellfish, human outbreaks still occur. After providing an overview showing their implication in disease, this review aims to highlight the diversity of the bacteria or enteric viruses detected in shellfish species, including emerging pathogens. After a critical discussion of the available methods and their limitations, we address the interest of technological developments using genomics to anticipate the emergence of pathogens. In the coming years, further research needs to be performed and methods need to be developed in order to design the future of surveillance and to help risk assessment studies, with the ultimate objective of protecting consumers and enhancing the microbial safety of bivalve molluscan shellfish as a healthy food.
Seroprevalence Study of Conserved Enterotoxigenic Escherichia coli Antigens in Globally Diverse Populations
Authors: Kuhlmann Frederick Matthew , Grigura Vadim , Vickers Timothy J. , Prouty Michael G. , Iannotti Lora L. , Dulience Sherlie Jean Louis , Fleckenstein James M.
Published: September 2023

Enterotoxigenic Escherichia coli (ETEC) are common causes of infectious diarrhea among young children of low-and middle-income countries (LMICs) and travelers to these regions. Despite their significant contributions to the morbidity and mortality associated with childhood and traveler’s diarrhea, no licensed vaccines are available. Current vaccine strategies may benefit from the inclusion of additional conserved antigens, which may contribute to broader coverage and enhanced efficacy, given their key roles in facilitating intestinal colonization and effective enterotoxin delivery. EatA and EtpA are widely conserved in diverse populations of ETEC, but their immunogenicity has only been studied in controlled human infection models and a population of children in Bangladesh. Here, we compared serologic responses to EatA, EtpA and heat-labile toxin in populations from endemic regions including Haitian children and subjects residing in Egypt, Cameroon, and Peru to US children and adults where ETEC infections are sporadic. We observed elevated IgG and IgA responses in individuals from endemic regions to each of the antigens studied. In a cohort of Haitian children, we observed increased immune responses following exposure to each of the profiled antigens. These findings reflect the wide distribution of ETEC infections across multiple endemic regions and support further evaluation of EatA and EtpA as candidate ETEC vaccine antigens.