bluuebunny/crossref_metadata_2025 huggingface dataset:
DIGITAL TRANSFORMATION OF THE GLOBAL SERVICE MARKET: TRENDS, CHALLENGES, AND PROSPECTS
Authors:   Kyiv National Economic University named after Vadym Hetman, Solodkovska Ganna , Avksientiev Yurii ,   Kyiv National Economic University named after Vadym Hetman
Published: December 2024

Digital transformation represents a critical force driving changes in the global service market, reshaping the traditional models of service delivery and customer interaction. This paper explores the primary trends underpinning digital transformation, including the integration of artificial intelligence (AI), cloud computing, the Internet of Things (IoT), and advanced data analytics. These technologies not only optimize business processes but also enhance service quality, offering enterprises the tools to adapt to the evolving needs of consumers in a rapidly changing global economy. The study highlights significant challenges, such as ensuring cybersecurity, addressing ethical concerns regarding AI deployment, and navigating the complexities of global turbulence. Particular attention is given to the role of digital platforms and ecosystems in fostering resilience, efficiency, and scalability in service provision. Additionally, the paper emphasizes the importance of environmental sustainability, as rising consumer awareness increasingly influences service providers to adopt greener technologies and practices. Moreover, this research identifies emerging opportunities in the global service market. These include the development of smart services powered by IoT and AI, enhanced customer personalization through data-driven insights, and the implementation of flexible business models that embrace remote and hybrid work environments. The findings suggest that the successful adoption of these technologies enables companies to maintain competitiveness while addressing critical issues such as regulatory compliance and environmental impact. The analysis concludes by outlining strategic recommendations for companies to harness digital transformation effectively. By investing in innovative technologies, fostering interdisciplinary partnerships, and aligning with consumer expectations for sustainability and convenience, businesses can secure their position in an increasingly competitive and interconnected global marketplace. This paper serves as a foundational reference for understanding the multifaceted impact of digital transformation on the service industry and its pivotal role in shaping future global economic dynamics.
La afectación aórtica complicada existe en la enfermedad de Pompe de inicio tardío. ¿Debemos tratarla?
Authors: Pertusa-Mataix Roberto , Garrido-Montes Manuel , García-Morillo José Salvador
Published: December 2024

La enfermedad de Pompe de inicio tardío (late-onset Pompe disease, LOPD) es un trastorno raro caracterizadopor acumulación de glucógeno en el tejido muscular. Presentamos un caso con afectación vascular aórtica,manifestada como úlcera aórtica y hematoma intramural. Las pruebas genéticas confirmaron mutacionesen el gen GAA (ácido alfa glucosidasa), y la paciente fue diagnosticada con LOPD. Se optó por un manejoconservador, con control estricto de la presión arterial. Tras 12 meses, la evolución fue estable sin necesidadde terapia de reemplazo enzimático. Este caso resalta la importancia de considerar complicaciones vascularesen la LOPD.
Detrás de los movimientos
Authors: Toscano-Ruiz Leire , Cattoni-Rojas Ignacio
Published: December 2024

Se presenta el caso de un hombre de 90 años, diabético tipo 2 que ingresó por infección respiratoria. Habíapresentado descompensaciones hiperglucémicas hiperosmolares (glucemia 500 mg/dL) las semanas previasen el seno de infecciones respiratorias de repetición. Durante la exploración se observaron movimientosinvoluntarios irregulares, repetitivos y breves que afectaban a extremidad superior izquierda proximal, diagnosticándosede síndrome hemicoreico izquierdo. Tras descartar causa farmacológica y vascular, se confirmómediante historia clínica y resonancia magnética hemicorea de síndrome de hiperglucemia hiperosmolarno cetósica (SHH). Tras hidratación, insulinoterapia bolo-basal y tratamiento anticinetósico hubo mejoríasintomática parcial, aunque con episodios de trastorno motor hipercinético residual.presentado descompensaciones hiperglucémicas hiperosmolares (glucemia 500 mg/dL) las semanas previasen el seno de infecciones respiratorias de repetición. Durante la exploración se observaron movimientosinvoluntarios irregulares, repetitivos y breves que afectaban a extremidad superior izquierda proximal, diagnosticándosede síndrome hemicoreico izquierdo. Tras descartar causa farmacológica y vascular, se confirmómediante historia clínica y resonancia magnética hemicorea de síndrome de hiperglucemia hiperosmolarno cetósica (SHH). Tras hidratación, insulinoterapia bolo-basal y tratamiento anticinetósico hubo mejoríasintomática parcial, aunque con episodios de trastorno motor hipercinético residual.
Síndrome de Ekbon como manifestación de una colecistitis xantogranulomatosa
Authors: Moreno Díaz Javier , Artajona-Rodrigo Ester , Arche-Banzo María José , Jaqués-Andrés Clara , Pérez-Tausía Daniel , Escartín-Valderrama Jorge , Morellón-Baquera Raquel
Published: December 2024

El síndrome de Ekbom es un trastorno psiquiátrico en el que el paciente cree estar infestado por bacterias,virus o gusanos, pudiendo ser un trastorno primario o secundario. Se presenta un caso de un varón de 72años con un delirio de infestación como única sintomatología, sin sospecha inicial de cuadro orgánico debase por tener una exploración física normal y analíticas sin marcadores de infección o inflamación elevados.Durante el ingreso, el paciente fue trasladado a Cuidados Intensivos por cuadro de shock, demostrándose enTAC abdominal cuadro compatible con colecistitis aguda sobre una colecistitis crónica de tipo xantogranulomatoso.Los trastornos de infestación son raros como delirio secundario, por lo que es importante conocerque en pacientes mayores pueden estar asociados a cuadros orgánicos larvados.
Endometriosis del canal de Nuck: una rara causa de tumoración inguinal
Authors: Huergo-Fernández Olaya , González-San Narciso Candela , De Luis-Yanes Jorge , Cano-Ballesteros Juan Carlos
Published: December 2024

La endometriosis del canal de Nuck es una patología muy poco frecuente que en ocasiones puede malignizar.Es importante su conocimiento a la hora de realizar diagnóstico diferencial de tumoraciones inguinalesen la mujer. Exponemos el caso de una mujer de 43 años con antecedente de endometriosis derivada ala consulta de Diagnóstico Rápido por una tumoración en la región inguinal derecha dolorosa de formacíclica. Ante la sospecha de un foco de endometriosis, solicitamos pruebas de imagen y biopsia llegando aldiagnóstico de endometriosis del canal de Nuck.
Leucoencefalopatía con sustancia blanca evanescente: un fenotipo intermedio en relación a una mutación heterocigota en EIF2B2
Authors: Quintanilla-Carrillo Belén , Pertusa-Mataix Roberto , García-Morillo José Salvador
Published: December 2024

Presentación de un caso atípico de leucoencefalopatía con sustancia blanca evanescente (LSBE) en pacientejoven con clínica compatible y mutación patogénica heterocigota en el gen EIF2B2. Este caso pone demanifiesto la importancia de la secuenciación génica en el despistaje de «enfermedades raras» como lasleucoencefalopatías y presenta, por primera vez, un fenotipo intermedio de LSBE de inicio en edad adultaen relación a una mutación patogénica heterocigota en EIF2B2.
Risk Factors of Cardiovascular Diseases among Medical Staff in Saudi Arabia
Authors: Ibtisam Alharthi  , Amani Alasmar  , Sultan Althobaiti
Published: December 2024

Healthcare workers have an increased risk of developing cardiovascular diseases as a work-related disease and also due to the sedentary lifestyle, unhealthy behavior, and occupational stress to which they are exposed. This study investigates the prevalence and risk factors of CVDs among medical staff at Prince Sultan Military Medical City, Riyadh, Saudi Arabia. A cross-sectional study was conducted among 291 medical staff at Prince Sultan Military Medical City, Riyadh, using stratified random sampling. Data were collected through the WHO STEPS questionnaire, physical measurements (BMI, blood pressure), and biochemical assessments (lipid profiles, glucose levels). Statistical analyses, including logistic regression, were performed using SPSS version 26 to identify the prevalence and determinants of CVD risk factors. Ethical approval was obtained, and all participants provided informed consent.The mean age of participants was 35 years, with 20% being smokers and 50% insufficiently active. Obesity (50%), hypertension (30%), and diabetes (10%) were prevalent clinical risk factors. High LDL cholesterol (30%) and low HDL cholesterol (20%) were observed. Key predictors of CVD included hypertension (OR = 3.20), diabetes (OR = 2.80), obesity (OR = 2.50), and high stress levels (OR = 1.60). This study underscores the need for workplace health interventions targeting modifiable CVD risk factors among healthcare workers in Saudi Arabia.
Gothic and Historical Elements in Washington Irving’s “The Legend of Sleepy Hollow”
Authors: Kay L. Oaks
Published: December 2024

Washington Irving’s short story “The Legend of Sleepy Hollow” still haunts us today 200 years after it was written. Irving incorporated Gothic elements such as ancient and isolated settings, nature, superstitions, and supernatural ambiguity into his short story.  Irving also included historical figures such as the British Major John André  and the headless Hessian soldier.  The author wove elements of the Gothic with historical facts from the American Revolution to create a memorable, uniquely American story.
Analysis of Inclusive Economic Development and Its Driving Factors in Papua Province
Authors: Titalessy Pisi Bethania , Situmeang Radian Januari , Mulyono Herlina Irianti , Patty Richard
Published: December 2024

Papua Province, known for its abundant natural resources and cultural diversity, faces significant challenges in achieving inclusive economic development. Persistent disparities in income, infrastructure, and access to essential services have hindered equitable growth and social welfare improvement. This study examines the inclusiveness of economic development in Papua and explores its driving factors. Utilizing secondary data from the Ministry of National Development Planning/National Development Planning Agency (Badan Perencanaan Pembangunan Nasional, Bappenas), BPS - Statistics Indonesia (Badan Pusat Statistik, BPS), and the Directorate General of Fiscal Balance (Direktorat Jenderal Perimbangan Keuangan, DJPK) for 2017–2021, the research employs descriptive analysis and panel data regression methods. The panel regression results highlight the critical role of fiscal policies in promoting inclusivity. Economic expenditures demonstrate a positive and significant impact on inclusive development, fostering equitable economic participation and productivity. In contrast, basic infrastructure spending shows a significant negative effect, possibly due to uneven allocation or misalignment with local community needs. While education expenditures are not statistically significant, they exhibit potential for enhancing inclusivity through long-term human capital development. These findings underscore the importance of targeted and well-distributed fiscal policies to address Papua’s unique socio-economic challenges. By prioritizing human capital, aligning infrastructure investments with local needs, and fostering balanced economic growth, policymakers can pave the way for more inclusive development across the province. This research provides valuable insights for designing effective policy interventions to reduce inequality and foster sustainable economic growth in Papua.
NEW SAFETY CHALLENGES OF CEMENT-CONTAINING BUILDING MATERIALS AND PRODUCTS FROM THEM
Authors: Logvinkov S. , Ivashchenko M. , Shumeіko V. , Maksimenko O.
Published: December 2024

The article considers a new problem of harmful effects of Portland cement on humans due to the possibility of
releasing ammonia during hydration hardening of materials and products based on it. It notes the relationship
between the analyzed problem and the intensification of energy and resource saving at modern cement plants, which
allows nitrogen-containing materials to enter Portland cement: as part of raw materials; with materials utilized in
high-temperature zones of rotary kilns and as part of additives introduced during grinding of cement clinker.
Probable sources of ammonia release from Portland cement during its hydration are analyzed in a logical sequence
and taking into account the chemical specificity of various groups of nitrogen-containing compounds. The most
theoretically substantiated and experimentally confirmed hypothesis is chosen about the synthesis of iron nitrides in
high-temperature zones of rotary kilns for burning cement clinker – the main sources of subsequent ammonia
emission during hydration of Portland cement. A set of conditions necessary for the synthesis of iron nitrides is
considered. The debatable nature of the issue of the stability of stoichiometric iron nitride Fe8N is indicated and it is
proposed to consider it as a solid solution along with stoichiometric compounds Fe4N and Fe2N when analyzing
chemical processes of hydration with the formation of ammonia. Possible solutions to the problem at the place of its
occurrence - Portland cement plants – are discussed.
The expediency of depleting sources of ammonia emission at the initial stages of hydration hardening of
Portland cement is shown, which significantly reduces the risk of harmful effects on the human body.
A method for eliminating the problem at large enterprises consuming Portland cement in significant quantities
for the manufacture of dry building mixtures, concrete and products from them is selected. The essence of the
method for proactively removing the main amount of ammonia emission sources at the initial stage of Portland
cement hydration in the presence of the additive Ca(NO3)2 is described. Theoretical and practical arguments are
presented about the positive effect of small amounts of Ca(NO3)2 on the formation of the microstructure and
operational characteristics of cement stone, which additionally stimulates the implementation of the proposed
method. The need for a comprehensive large-scale study of all possible manifestations of the analyzed problem with
the involvement of specialists from sanitary and hygienic services is emphasized.
DETERMINATION OF THE FREQUENCY OF NATURAL OSCILLATIONS OF THE ELEMENTS
OF THE MECHANICAL SYSTEM OF THE MOTOR CARRIAGE ROLLING STOCK
Authors: Tishchenko V. , Lohvinenko O.
Published: December 2024

Of particular importance is the problem of operational reliability and durability of locomotive power units (diesel engines), which equip a significant portion of freight and passenger rolling stock operating on non-electrified railway networks in Ukraine. This necessitates conducting computational and experimental studies of the stress-strain state of critical diesel engine parts and assemblies, among which the camshaft holds a special place. At the same time, such studies require, as one of the stages, measures aimed at developing an appropriate mathematical model that considers the peculiarities of formation of accumulating torque moments in the camshaft subsystem. Therefore, research aimed at developing a mathematical model that considers the design features of the mechanical system of a multi-cylinder locomotive diesel engine and allows obtaining simulation results of the camshaft stress state close to operational indicators should be considered relevant.
The article highlights an approach to modeling torque accumulation in the diesel engine camshaft subsystem using a mathematical model developed by the authors, which takes into account the design features of the mechanical system of modern traction rolling stock. A structural-functional scheme of the locomotive power unit (LPU) mechanical system is presented, which was developed to study the interaction between its subsystems, the description of which is paramount among the series of stages in studying the loaded state of the LPU mechanical system elements. This scheme contains several subsystems, namely: the camshaft subsystem; cylinder modules; crankshaft; transmission mechanism; and auxiliary equipment. Its analysis allowed noting that loads in the camshaft subsystem are formed from the action of input torque and accumulation of series torque moments, which in turn include loads in the sections of valve gear cam mechanisms and high-pressure fuel pump drives.
The presented results show the modeling of torque formation in the sections of intake and exhaust valves of the valve gear mechanism, fuel cams, and in the section of the camshaft drive gear. Generalized formulas are provided, which allowed obtaining arrays of torque moments in the sections of valve gear cam mechanisms and high-pressure fuel pump drives. It is noted that the formation of torque layering across cylinder modules occurs in accordance with the design features of the LPU mechanical system. Recommendations for further use of the obtained results are provided.
ON THE ISSUE OF ASSESSING THE EFFECTIVENESS OF DESIGN SOLUTIONS TO ENSURE THE SUSTAINABILITY OF THE URBAN TRANSPORT SYSTEM
Authors: Lyfenko S. , Ponkratov D. , Sabadash V.
Published: December 2024

Modern transport problems in many cities around the world are caused by the high level of motorisation of their population and the high frequency of private car use. Despite a number of advantages of using private cars as a means of transport (high speed of communication, the ability to choose a route and travel at a convenient time, high comfort, etc.), the mismatch between the development of motorisation and the existing transport infrastructure leads to traffic congestion, which has a number of negative consequences that make the use of private cars less efficient. These consequences include increased transport delays, reduced traffic speeds and, consequently, increased travel time, and more intensive consumption of non-renewable energy sources. Equally urgent are the issues of road safety and improving the environmental situation in cities. At present, a promising way to solve urban transport problems is to apply the concept of sustainable development of urban transport systems and the methodology of transport demand management.
The justification of design solutions to ensure the sustainability of urban transport systems should be based on a model approach and include a comprehensive assessment of a number of social, economic and environmental performance indicators. The adequacy of transport models and the accuracy of the assessment of the consequences of design decisions are crucial for choosing the most appropriate set of measures to ensure the sustainability of transport systems.
The article proposes an efficiency criterion for evaluating design solutions to ensure the sustainability of the city's transport system, which contribute to reducing the use of private car. This criterion provides for a comprehensive assessment of the effectiveness of design solutions in terms of economic, social and environmental performance indicators.
Based on the analysis of statistical data, it was found that the following distribution of passenger cars by type of fuel consumed is typical for Kharkiv: cars with petrol engines - 48.58%; diesel cars - 14.63%; cars with gas cylinder equipment - 33.58%; electric cars - 3.21%. The established distribution of passenger cars by type of fuel consumed is the basis for establishing average values of variable and fixed operating costs of private car owners and should be taken into account when assessing the environmental impact of the transport process. This is the direction of further research.
WAYS TO IMPROVE THE FUNCTIONING OF THE TRANSPORTATION SYSTEM IN THE POST-WAR PERIOD
Authors: Fomenko Н.
Published: December 2024

Introduction. The article addresses the critical issue of transportation systems as a key component for each state. These systems fulfill multiple functions aimed at ensuring efficient coordination in transport processes. Urban transportation infrastructure, in particular, demands focused attention. In the post-war period, to foster economic development and improve environmental conditions, it is essential to implement and advance innovative and digital technologies. Purpose. The purpose is to explore the directions for the development of transportation infrastructure and to identify ways to promote priority areas in the innovative processes within transportation systems. Results. At present, there is a pressing need to consider the prospects and restoration of urban areas damaged by hostilities. Planning for restoration cannot be deferred until the post-war period when martial law is lifted. Transportation is one of the main components of infrastructure that influences regional development and has strategic importance. Attention must be given to the factors and conditions shaping the formation and development of the transportation system. Given that a city’s transportation system encompasses the collection of infrastructure facilities and services for operation and maintenance, the responsibility for its development lies primarily with municipal authorities. Transportation and transport planning are often not independent objects of development plans but rather serve as baseline conditions. The goal of transportation policy, aimed at urban development, should not be solely the development of transportation itself but must consider its integration with the development of economic, environmental, and social elements. An essential aspect of transportation system development is the application of innovative activities. Innovation in the transportation sector should focus on defining the level of technical advancement, which significantly affects performance indicators such as work quality and productivity within the industry. Conclusions. Implementing modern innovative methods in the restoration processes of transportation infrastructure will contribute to improving the quality of life and the living standards of the population.
IMPACT OF ASTAXANTHIN ON MANIFESTATIONS OF THE DIRECT AND RESCUE TUMOR-INDUCED BYSTANDER EFFECT
Authors:   Educational and Scientific Center «Institute of Biology and Medicine» of the Taras Shevchenko Kyiv National University, Rushkovsky S. R. , Demchenko O. M. ,   State Institution «National Research Center for Radiation Medicine, Hematology and Oncology of the National Academy of Medical Sciences of Ukraine», Romanenko M. H. ,   State Institution «National Research Center for Radiation Medicine, Hematology and Oncology of the National Academy of Medical Sciences of Ukraine», Makarchuk M. Yu. ,   Educational and Scientific Center «Institute of Biology and Medicine» of the Taras Shevchenko Kyiv National University, Kurinnyi D. A. ,   State Institution «National Research Center for Radiation Medicine, Hematology and Oncology of the National Academy of Medical Sciences of Ukraine»
Published: December 2024

Objective: to investigate the reciprocal impact on the genome of malignant and normal human peripheral blood lymphocytes under their co-culture and the possibility to modify the effects by astaxanthin.
Methods. Separate and joint/separate culturing of peripheral blood lymphocytes (PBL) of the chronic lymphocytic leukemia (CLL) patients (n = 6) and conditionally healthy individuals (n = 6), Comet assay method, fluorescence microscopy with automated software for the analysis of results, statistical methods.
Results. Both direct and rescue tumour-induced bystander effects were observed under the joint/separate culturing of blood lymphocytes of conditionally healthy individuals (the bystander cells) and blood cells from CLL patients (the inducer cells). The direct effect was characterized by the high level of comets corresponding to the S-phase cells and increased apoptotic activity in the bystander cell cultures. The rescue effect in the culture of inducer cells was expressed by the increased frequency of cells retained in S-phase, decreased proportion of cells with a high level of DNA damage and decreased amount of cells in apoptotic stage. Level of both S-phase cells and apoptotic cells in the cultures of bystander cells significantly decreased under the impact of astaxanthin (p < 0.05). Effect of astaxanthin on the inducer cells was the opposite, namely an increased frequency of S-phase cells and increased apoptotic activity in cultures (p < 0.05) was observed.
Conclusions. Possible modification of manifestations of both direct and rescue tumor-induced bystander effects by the astaxanthin was established.
Key words: astaxanthin; joint/separate culturing of human lymphocytes; direct and rescue tumorinduced bystander effects; Comet assay, apoptosis.
STUDY OF CHROMOSOME STABILITY OF HUMAN SOMATIC CELLS IN THE DEVELOPMENT OF THE SECONDARY RADIATION-INDUCED BYSTANDER EFFECT
Authors:   State Institution «National Scientific Center for Radiation Medicine, Hematology and Oncology of the National Academy of Medical Sciences of Ukraine», Shemetun O. V. , Talan O. A. ,   State Institution «National Scientific Center for Radiation Medicine, Hematology and Oncology of the National Academy of Medical Sciences of Ukraine», Dibska O. B. ,   State Institution «National Scientific Center for Radiation Medicine, Hematology and Oncology of the National Academy of Medical Sciences of Ukraine»
Published: December 2024

Objective. To establish the level of chromosomal instability in human peripheral blood lymphocytes during the development of secondary radiation-induced bystander effect.
Materials and methods. Human peripheral blood lymphocytes; culture of human non-small-cell lung cancer cell line A549 (irradiated in vitro by 137Cs in a dose of 0.50 Gy/unirradiated). Cytogenetic analysis of uniformly colored chromosomes of human peripheral blood lymphocytes with determination of the frequency of all types of aberrations.
Results. The mean group frequency of chromosome aberrations (4.75 per 100 cells) in human peripheral blood lymphocytes co-cultivated with conditioned culture medium from bystander cells of human non-small cell lung cancer cell lines A-549 exceeded the control (1.60 per 100 cells) (p < 0.001) due to an increase in the frequency of single fragments from 1.20 to 3.95 per 100 cells (p < 0.001). The mean group frequency of chromosome aberrations and chromatid-type aberrations in human peripheral blood lymphocytes during the development of primary (5.80 and 4.35 per 100 cells, respectively) and secondary (4.75 and 3.95 per 100 cells, respectively) radiation-induced bystander effect did not significantly differ from each other (p > 0.05).
Conclusions. Under the conditions of co-cultivation of human peripheral blood lymphocytes with conditioned culture medium from bystander cells of human non-small cell lung cancer A-549, a secondary radiation-induced bystander effect was registered, the cytogenetic manifestation of which was an increase in the level of chromosomal instability due to the rise in the frequency of chromatid-type aberrations (single fragments). The levels of chromatid-type chromosome aberrations during the development of the primary and secondary radiation-induced bystander effect did not differ significantly. The development of the secondary radiation-induced bystander effect did not affect the induction of chromosomal-type aberrations.
Key words: radiation-induced bystander effect; human peripheral blood lymphocytes; chromosome aberrations; human non-small cell lung cancer cell lines A-549.
MOLECULAR-GENETIC PHENOTYPES OF BREAST CANCER, THEIR PROLIFERATIVE ACTIVITY, DEGREE OF SPREADING AND DIFFERENTIATION IN PATIENTS WHICH WERE SUFFERED BY THE ACCIDENT AT ChNPP
Authors:   State Institution «National Research Center for Radiation Medicine, Hematology and Oncology of the National Academy of Medical Sciences of Ukraine», Bazyka D. A. , Litvinenko O. O. Litvinenko ,   State Institution «National Research Center for Radiation Medicine, Hematology and Oncology of the National Academy of Medical Sciences of Ukraine»
Published: December 2024

Objective: analysis of molecular genetic phenotypes, their proliferative activity, degree of spread and differentiation of tumors in breast cancer patients affected by the accident at the Chornobyl Nuclear Power Plant.
Materials and methods. 96 breast cancer patients who were exposed to ionizing radiation as a result of the accident at the Chornobyl Nuclear Power Plant were examined. Clinical, radiological, instrumental, morphological, immunohistochemical research methods were used.
Results and conclusions. In patients who have been exposed to radiation, the frequency with which the molecular genetic phenotypes of breast cancer occur is somewhat different from the generally known data. Thus, luminal A phenotype was diagnosed in 17.7 %, luminal B in 56.2 %, HER2/neu expressing in 6.2 % and triple negative (TN) phenotype in 19.8 % patients. Proliferative activity indicators on average in patients with luminal A phenotype were at the level of 12.7 %, luminal B – 41.5 %, triple negative – 55.6 %, and HER2/neu positive breast cancer – 32.5 %. Patients with different molecular genetic phenotypes are diagnosed with different prevalence values of the TNM criteria. Metastatic lesions of regional lymph nodes (LNs) were diagnosed in 97.9 % of patients belonging to all phenotypes of breast cancer. Ki-67 values that did not exceed 20 % were found in 22.9 % of patients, the main number – 17.7 % had the luminal A subtype. In 77.1 % of patients, Ki-67 values were beyond 20 %, which indicates a more aggressive course of the disease in the majority of patients, which included patients with various molecular genetic subtypes, except for luminal A. A high degree of differentiation of mammary gland tumors was diagnosed in 8.3 % of patients. The main number of them, 6.2 %, had the luminal A phenotype. A moderate degree of differentiation was found in 65.6 %, where 43.7 % of patients had a luminal B HER2/neu negative phenotype. A low degree of differentiation was diagnosed in 26 % of patients, among whom 12.5 % were diagnosed with TN, and 9.4 % had a luminal B HER2/neu negative phenotype.
Key words: breast cancer, molecular genetic phenotypes, proliferative activity, degree of spread, degree of differentiation.
PATHOGENESIS OF RADIATION COMPLICATIONS IN NORMAL TISSUES SURROUNDING AN IRRADIATED TUMOUR (review)
Authors:   R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Domina E. A.
Published: December 2024

Dedicated to the memory
of the outstanding Ukrainian radiobiologist
Mykola Oleksandrovych Druzhyna

The introduction of new radiation technologies in modern radiotherapy of cancer patients is still in some cases associated with the risk of developing early and distant complications in healthy tissues surrounding the tumour. The causes of their occurrence, pathogenesis and radiobiological characteristics are reviewed and briefly described. The rate of the manifestation of complications depends on the radiosensitivity of tissues and is determined by the amount of absorbed dose of ionizing radiation. In contrast to early complications, the development of distant radiation effects is irreversible and progressive. The features of early radiation complications are considered on the example of patients with gynaecological oncology, the incidence of which has been rapidly increasing in recent years. The interest of researchers in this pathology is due to the danger of developing complications from critical pelvic organs. Attention is focused on determining the individual radiosensitivity of the patients' body using the chromosomal G2 test to predict the development of post-radiation complications. The paper advocates for the necessity of developing nontoxic radioprotectors that would show affinity only to healthy tissues, would not require additional concomitant therapy and would definitely improve the quality of life of patients.
Key words: radiation therapy; ionizing radiation; cancer patients; post-radiation complications; pathogenesis; radiobiological characteristics; healthy tissues; radioprotection.
PATTERNS OF DEVELOPMENT OF CLINICAL AND FUNCTIONAL DISORDERS OF THE BRONCHOPULMONARY SYSTEM IN THE POST-ACCIDENT PERIOD IN PERSONS EXPOSED TO IONIZING RADIATION
Authors:   State Institution «National Research Center for Radiation Medicine, Hematology and Oncology of the National Academy of Medical Sciences of Ukraine», Shvaiko L. I. , Bazyka K. D. ,   State Institution «National Research Center for Radiation Medicine, Hematology and Oncology of the National Academy of Medical Sciences of Ukraine», Shilenko M. V. ,   State Institution «National Research Center for Radiation Medicine, Hematology and Oncology of the National Academy of Medical Sciences of Ukraine», Savchenko A. A. ,   State Institution «National Research Center for Radiation Medicine, Hematology and Oncology of the National Academy of Medical Sciences of Ukraine», Tkachuk N. A. ,   State Institution «National Research Center for Radiation Medicine, Hematology and Oncology of the National Academy of Medical Sciences of Ukraine»
Published: December 2024

The objective of the study was to establish the relationship between functional status of bronchopulmonary system and obstructive sleep apnea in clean-up workers of Chornobyl NPP accident in a remote post-accident period.
Materials and methods. A retrospective analysis of 824 cases of COPD in male patients who underwent inpatient treatment in the radiation pulmonology department from 2014 to 2024 was conducted. The observation groups included 579 (70.3%) of urban residents (main group) and 245 (29.7%) of COPD patients (nosological control) who were irradiated within the natural background. For prospective observation, 100 COPD patients from urban residents and 30 COPD patients from the NC group were selected. A complex of clinical and functional tests was provided.
Results. In clean-up workers of Chornobyl NPP accident with COPD The regularities of damage to the bronchopulmonary system under the influence of ionizing radiation should be considered a change in the minimal clinical symptoms of the early period, the rapid development of fibrotic changes in the lungs and bronchial mucosa, which is accompanied by a deepening of violations of functional pulmonary tests, structural and morphological changes according to the results of radiological research methods.
Conclusions The analysis of various patterns and phenotypes of COPD requires further study in order to improve early diagnosis and treatment of the disease, in particular in people who have suffered as a result of exposure to ionizing radiation.
Key words: clean-up workers of Chornobyl NPP accident, pulmonary function tests.
IMPLEMENTATION OF THE EDUCATIONAL MODULE «MANAGING EXPOSURE ASSESSMENT AND MEDICAL RESPONSE TO A RADIATION EMERGENCY IN UKRAINE»
Authors:   The WHO Country Office in Ukraine, Akbarov K. , Korol N. ,   The WHO REMPAN Collaborating Center, State Institution «National Research Center for Radiation Medicine, Hematology and Oncology of the National Academy of Medical Sciences of Ukraine», Yanovych L. ,   The WHO REMPAN Collaborating Center, State Institution «National Research Center for Radiation Medicine, Hematology and Oncology of the National Academy of Medical Sciences of Ukraine», Vasylenko V. ,   The WHO REMPAN Collaborating Center, State Institution «National Research Center for Radiation Medicine, Hematology and Oncology of the National Academy of Medical Sciences of Ukraine», Bruni E. ,   The WHO Country Office in Ukraine, Habicht J. ,   The WHO Country Office in Ukraine
Published: December 2024

The WHO educational module УДК «Ma naging exposure assessment and medical response to a radiation emergency in Ukraine» was developed and implemented. In total, 25 trainings were conducted for 377 healthcare professionals from 6 regions of Ukraine during 2023–2024.
Key words: WHO, NRCRM, radiation emergency, medical preparedness, educational module.
TR53 AND IONIZING RADIATION: THE ROLE IN THE PATHOGENESIS AND PROGNOSIS OF THE COURSE OF ACUTE MYELOID LEUKEMIA (literature review)
Authors:   Bogomolets National Medical University, Liubarets T. F.
Published: December 2024

The review presents literature data on the role of the ТР53 gene and ionizing radiation (IR) in the pathogenesis of acute myeloid leukemia (AML).The violation of ТР53 functioning as a promoter of AML induction under the influence of negative external factors (IR, chemotherapeutic agents) was analyzed. New directions of AML stratification are presented, which will allow to optimize the future therapy and extend the life expectancy of this category of patients.
Key words: acute myeloid leukemia, treatment options, ТР53, ionizing radiation.
Теоретично-методологічний аналіз проблеми адаптації особистості в умовах травмівного досвіду
Authors: Бохонкова Юлія , Ліпський Анатолій
Published: December 2024

Стаття присвячена аналізу проблеми адаптації особистості в умовах отриманого нею травмівного досвіду. Представлено історичний аналіз проблеми. Надано психологічне тлумачення понять «травмівний досвід», «психологічна травма», «психологічна резильентність». Проаналізовано культурні та соціальні фактори, які впливають на адаптацію.Охарактеризовано наслідки травми для особистості.Зроблено акцент на аналізі практик та технік, які довели свою ефективність у відновленні після травматичних подій. Описано особливості впливу зовнішніх та внутрішніх факторів на адаптивність особистості. Визначено, що історичний огляд певної проблеми допомагає зрозуміти, як різні епохи та соціальні умови впливають на формування підходів щодо подолання травми та адаптації, а також на способи взаємодії особистості, яка знаходиться під впливом травмівного досвіду. Окрему увагу приділено тривалості травмівного досвіду. Зазначено, що люди, які переживають раптові, короткострокові стресові події, можуть мати інші стратегії адаптації порівняно з тими, хто зазнає впливу довготривалих стресорів.
Соціально-психологічні особливості розвитку особистості в сучасних умовах трансформаційного суспільства
Authors: Бочелюк Віталій , Лукашов Олександр , Круглов Костянтин , Омелянюк Сергій
Published: December 2024

У статті представлено огляд наукових джерел з питання соціально-психологічних змін особистості під впливом трансформаційних змін у суспільстві. Визначено загальне поняття трансформаційного суспільства та його основні характеристики. Охарактеризовано особливості сучасного етапу суспільних трансформацій: висока швидкість, глобальність простору змін, виникненням раніше невідомих соціальних форм та тісний взаємозв’язок особистості із суспільними процесами. Під впливом трансформаційних змін суспільства особистість втрачає зовнішні опори (суспільні цінності, традиції, звичні форми поведінки), проте має можливість посилення внутрішніх опор. У трансформаційному суспільстві розвиваються такі вольові особистісні якості як самостійність, цілеспрямованість, здатність долати перешкоди на шляху до досягнення мети. Рятівними чинниками, що сприятимуть виходу із кризи та переходу людської цивілізації на новий етап розвитку є глобалізація, тобто об’єднання людства та усвідомлення їх взаємозв’язку та відповідальності, а також реалізація людського життєвого потенціалу.
Ключові слова: трансформаційне суспільство, розвиток особистості, бізнес-лідерство, глобалізація, життєвий потенціал, соціальна відповідальність, безпека особистості, соціальні уявлення особистості.
COVID-19 tanısıyla yoğun bakımda takip edilen hastaların taburculuk sonrası yapılan ev ziyaretinin yaşam kalitesine etkisi
Authors: Kahraman Selma , Aslan Özcan
Published: December 2024

Amaç: COVID-19 tanısı almış ve yoğun bakımda takip edilen hastalara taburculuk sonrasında yapılan ev ziyaretlerinin hastaların yaşam kalitesine etkisini belirlemektir. Yöntem: Randomize olmayan kontrollü çalışmanın örneklemini, 21 deney, 21 kontrol grubu olmak üzere toplam 42 hasta oluşturmuştur. Araştırma verilerinin toplanmasında anket formu, COVID-19 hastasının taburculuk sonrası evde izlem ve bakım formu ve Yaşam Kalitesi Ölçeğinin kısa formu kullanılmıştır. Deney grubuna ayda bir olmak üzere toplam üç ev ziyareti, kontrol grubunda ise biri hastanede biri evde olmak üzere iki görüşme yapılmıştır. Analizler için tanımlayıcı istatistikler, bağımsız örneklem t-testi, ki-kare testi, Fisher’in kesin testi, tekrarlı ölçümlerde ANOVA, Friedman testi ve Mann-Whitney U testi uygulanmıştır. Tüm analizler için 0.05’in altındaki p değeri anlamlı kabul edilmiştir. Bulgular: Deney grubu hastalarının ilk ev ziyaretlerinde kuru öksürük şikayeti olanların oranı %52.4 iken, üçüncü ev ziyaretinde bu oranın %19’a düştüğü görülmüştür. Yaşam kalitesi ölçeğinin alt boyutu olan; genel durum puan ortalamaları deney grubunda, 1. ayda 5.33±2.15 iken, kontrol grubunda 6.00±1.73 olarak hesaplanmıştır. Üçüncü ayda ise genel durum puan ortalamaları deney grubunda 7.38±1.65, kontrol grubunda ise 5.52±1.74 olarak saptanmıştır. Yaşam Kalitesi Ölçeğinin diğer alt boyutları, deney grubundaki hastaların kontrol grubuna kıyasla üç aylık dönemde daha yüksek puanlara sahip olduğunu göstermiştir. Sonuç: Bu araştırma sonucunda; COVID-19 tanısıyla hastanede yatan ve taburcu olan hastalara hemşire tarafından verilen ev ziyaretlerinin hastaların yaşam kalitesini artırdığı, öksürük şikâyetinin azaldığı saptanmıştır.
Exploring Students' Learning Commitment Strata and Their Impact on Learning Outcomes
Authors: Tlonaen Zuvyati Aryani , Hoinbala Festif Rudolf , Ena Zet , Fitriyah Dewi Rohmatul
Published: December 2024

The problem addressed in this research is the variation in students' levels of learning commitment and how these differences impact their learning outcomes in a micro-teaching course. The samples were nine fifth-semester students (1 male and 8 females) from a Micro-teaching class, the English Language Education Study Program determined using purposive sampling with varying learning outcomes. Learning outcome data was taken from the final grades of the micro-teaching course. The learning commitment indicators consist of seven indicators arranged in 14 questions for each interview: interest in alternatives, acquiescence, cooperation, enhancement, identity, advocacy, and ownership. Data were analyzed using data reduction, data presentation, and conclusion. One student exhibited interest in alternatives commitment (score: 50.2), one student demonstrated acquiescence commitment (score: 61.1), three students showed advocacy commitment (scores: 75.5, 83.75, 89.75), and four students displayed ownership commitment (scores: 89.75, 90.6, 92.95, 95). No students were identified with cooperation, enhancement, or identity commitment strata. These results suggest a clear difference between students' learning commitment levels and learning outcomes in the microteaching course. The study concludes that students' learning commitment strata significantly impact learning outcomes, highlighting the importance of fostering strong learning commitment among students. The study recommends that educators implement strategies to strengthen students' learning commitment by encouraging higher levels of engagement and responsibility.
The Relationship of Adversity Quotient and Religious Culture on Students' Academic Achievement
Authors: Fuad A. Jauhar , Amin Muhammad Mahrus
Published: December 2024

The achievement of students is determined by their efforts. However, students tend to give up easily and become pessimistic when difficulties increase. This study shows that students tend to give up easily and become pessimistic when difficulties increase. This study aims to analyze the relationship between adversity quotient (AQ) and religious culture on student academic achievement in the Islamic Religious Education (PAI) Study Program. This study is a correlational survey study, with a population of 661 students with an average age of 20. The data scale used a Likert scale. The location of the study was Universitas Islam Tribakti Lirboyo Kediri. The study was conducted on second and fourth-semester students from February to July 2023 using purposive sampling techniques. Data analysis used regression analysis. Based on the calculations obtained, a significant relationship exists between adversity quotient and student academic achievement. There is a significant relationship between religious culture and academic achievement. A significant relationship exists between adversity quotient and religious culture on student academic achievement.
The Universal Values of Integrity Ūlul Al-Bāb through Work Ethic to Achievement Motivation and Performance of Lecturer at Islamic State University
Authors: Irawan Andik Rony , Mulyadi Mulyadi , Susilawati Samsul
Published: December 2024

This research explores the existential role of Ūlul Al-bāb's universal values ​​in improving work ethic, achievement motivation, and performance at UIN Maulana Malik Ibrahim Malang. Using quantitative methods and Partial Least Square-Sequential Equation Model (PLS-SEM) analysis, this research examines the relationship between variables, emphasizing the mediating role of work ethic. Two hundred respondents were selected from a population of 506 permanent lecturers. The research results show a positive and significant relationship between Ūlul Al-bāb values ​​and work ethic and performance, which confirms that internalization of objective, moderate, and transcendental principles can improve the performance of lecturers in the institution. However, the direct relationship with achievement motivation obtained insignificant results. This research also proves that work ethic emerges as an important mediator, connecting Ūlul Al-bāb values ​​with achievement motivation and performance. These findings confirm that a strong work ethic must translate these values ​​into performance improvements. The practical implications include human resource management in higher education.
Grit's Contribution to Developing Student School Engagement with Teacher Support as Moderator
Authors: Muallifah Muallifah , Hidayati Beti Malia Rahma , Ilhamuddin Ilhamuddin , Bulut Sefa
Published: December 2024

School engagement is an important aspect that supports students' academic success. This study aims to prove the contribution of grit moderated by teacher support to students' school engagement. The participants of this study were 237 students, consisting of 94 males and 143 females, who were selected through a purposive sampling technique. The analysis shows that grit positively and significantly affects students' school engagement [β = 0.433 (43.3%), p-value = 0.001]. In moderation, the teacher support variable can moderate the influence of the grit variable on school engagement, with the magnitude of the effect increasing to 0.497 (49.7%) and a significance value of P = 0.043. Additional results of gender analysis of the level of school engagement of students at school are more excellent for male students than female students. These findings can be used to increase student engagement in schools by strengthening the quality of student grit and by moderating the provision of teacher support and attention.