bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengembangan Buku Saku Berdasarkan Keanekaragaman Mikroalga di Daerah Aliran Sungai Ketahun
Authors: Simanungkalit Betania , Jumiarni Dewi , Irawati Sri , Kasrina Kasrina , Neni Murniati  , Abdul Rahman Sinkam
Published: December 2023

Mikrobiologi merupakah salah satu mata kuliah wajib bagi mahasiswa Pendidikan Biologi Universitas Bengkulu. Salah satu materi yang dipelajari dalam mata kuliah mikrobiologi adalah materi mikroalga. Terdapat beberapa masalah yang dihadapi mahasiswa dalam mempelajari mikroalga, sehingga dibutuhkan media pembelajaran berupa buku saku. Penelitian bertujuan untuk mengetahui kelayakan buku saku yang dikembangkan berdasarkan keanekaragaman mikroalga di Sungai Ketahun. Metode penelitian yang digunakan adalah metode Penelitian dan Pengembangan (Research and Development) menurut Borg dan Gall (1989) yang dimodifikasi oleh Sugiyono (2012) yang terbatas pada 7 tahap yaitu potensi dan masalah, pengumpulan data, desain produk, validasi desain, revisi desain, uji keterbacaan, dan revisi produk. Hasil validasi buku saku yang dikembangkan memperoleh rerata persentase validasi sebesar 93,33 % dengan kriteria sangat valid dan rerata persentase uji keterbacaan oleh mahasiswa sebesar 86,27 %  dengan kriteria sangat layak sehingga buku saku yang telah dikembangkan sangat layak digunakan untuk uji coba pemakaian dalam mata kuliah mikrobiologi materi mikroalga.Keywords: Buku Saku, Mikroalga, Sungai Ketahun
Diferensiasi Pembelajaran Virus Sebuah Pengembangan Instrumen Higher Order Thinking Skill (HOTS)
Authors: Apriani Shania Putri , Zuhro Meita Valentina , Siregar Nurhasanah , Ristanto Rizhal Hendi , Isfaeni Hanum
Published: December 2023

Pembelajaran abad 21 menekankan agar peserta didik mempunyai kompetensi berpikir kritis, kreatif, inovatif, komunikatif, kolaboratif dan kepercayaan diri. Kemampuan berpikir tingkat tinggi dalam diferensiasi pembelajaran perlu disatukan untuk memfasilitasi kebutuhan siswa yang berbeda-beda. Dalam penelitian ini dilakukan pengembangan instrumen soal berbasis HOTS dengan materi virus. Tujuan dari penelitian ini adalah mengembangkan instrumen penilaian Higher Order Thinking Skills (HOTS) pada materi virus berdasarkan pembelajaran diferensiasi pada peserta didik SMA kelas X IPA. Metode yang digunakan adalah research dan development (R&D) dengan desain penelitian model 4-D, meliputi tahap Define, Design, Develop dan Dessaminate. Hasil yang diperoleh untuk validitas teoritis terhadap 1 dosen sebagai ahli pendidikan dan 2 guru sebagai ahli materi adalah sebesar 89,03 %, hasil validitas empiris terhadap 110 siswa SMA kelas XI dan XII  menyatakan r hitung lebih besar dari r tabel, nilai reliabilitas instrumennya sebesar 0,977, analisis tingkat kesukaran soal menyatakan 30% (mudah), 63,33% (sedang) dan 6,67% (sukar), analisis daya pembeda menunjukkan 93,33% cukup memadai dan 6,67% lemah. Dapat disimpulkan bahwa soal yang digunakan dalam pengembangan instrumen penilaian sudah sangat baik dan memenuhi kriteria HOTS sehingga dapat digunakan sebagai instrumen penilaian materi virus kelas X SMA. Implikasi dari penelitian ini adalah agar siswa SMA terlatih untuk memecahkan soal dengan berfikir kritis.
Talasínup: Exploring the Environmental Consciousness and Christian Environmentalism of Youth Ministers in Mabalacat City in Light of Laudato Si' for Post-COVID-19 Environmental Stewardship
Authors: Waje Angelito Ortiz
Published: December 2023

This research investigates the influence of Pope Francis' encyclical Laudato Si on the attitudes and behaviors of Catholics regarding environmental stewardship in a post-COVID-19 context. The study employs a combination of quantitative and qualitative methods to comprehensively understand the impact of the encyclical and identify potential areas for future action and research in this critical field. The primary data collection involved a survey administered to 144 Catholic Youth Ministers in Mabalacat City, Pampanga. The survey included the Environmental Consciousness Scale and Christian Environmental Scale. Preliminary results indicate that Laudato Si has had a significant impact on Catholic perspectives and behaviors related to climate change and sustainability. The analysis of open-ended responses in the study provided valuable insights into the concerns and aspirations of the youth ministers. While personal aspects of life were the primary concerns for the youth, the youth ministers expressed deep concern about local pollution and the urban expansion on natural landscapes. They emphasized the importance of taking practical action to address these environmental issues and recognized the role of individual behaviors and societal structures in tackling these challenges. This research highlights the influential role of the Catholic Church in promoting environmental stewardship and the transformative power of religious teachings in elevating climate change concerns. The findings contribute to a better understanding of the influence of religious teachings on environmental attitudes and behaviors among Catholics. Furthermore, the insights generated in this study can inform policymakers, educators, and organizations seeking to promote environmental awareness and action among Catholic youth.
Unleashing Young Minds: Fostering Scientific Thinking in Early Childhood (Ages 5-9) through Experiential Learning in Kids Science Labs (STEM): Evaluation and Assessment
Authors: Salahova Aliya K.
Published: December 2023

Scientific thinking, characterized by purposeful knowledge-seeking and the harmonization of theory and facts, holds a crucial role in preparing young minds for an increasingly complex and technologically advanced world. This paper presents a research study aimed at fostering scientific thinking in early childhood, focusing on children aged 5 to 9 years, through experiential learning in Kids Science Labs (STEM). The study utilized a longitudinal exploration design, spanning 240 weeks from September 2018 to April 2023, to evaluate the effectiveness of the Kids Science Labs program in developing scientific thinking skills. Participants in the research comprised 72 children drawn from local schools and community organizations. Through a formative psychology-pedagogical experiment, the experimental group engaged in weekly STEM activities carefully designed to stimulate scientific thinking, while the control group participated in daily art classes for comparison. To assess the scientific thinking abilities of the participants, a registration table with evaluation criteria was developed. This table included indicators such as depth of questioning, resource utilization in research, logical reasoning in hypotheses, procedural accuracy in experiments, and reflection on research processes. The data analysis revealed dynamic fluctuations in the number of children at different levels of scientific thinking proficiency. While the development was not uniform across all participants, a main leading factor emerged, indicating that the Kids Science Labs program and formative experiment exerted a positive impact on enhancing scientific thinking skills in children within this age range. The study's findings support the hypothesis that systematic implementation of STEM activities effectively promotes and nurtures scientific thinking in children aged 5-9 years. Enriching education with a specially planned STEM program, tailoring scientific activities to children's psychological development, and implementing well-planned diagnostic and corrective measures emerged as essential pedagogical conditions for enhancing scientific thinking abilities in this age group. The results highlight the significant and positive impact of the systematic-activity approach in developing scientific thinking, leading to notable progress and growth in children's scientific thinking abilities over time. These findings have promising implications for educators and researchers, emphasizing the importance of incorporating STEM activities into educational curricula to foster scientific thinking from an early age. This study contributes valuable insights to the field of science education and underscores the potential of STEM-based interventions in shaping the future scientific minds of young children.
Attractiveness of Facial Symmetry in the Context of the Dominant Visual Field
Authors: Demuthova Slavka , Demuth Andrej
Published: December 2023

One of the key features of an attractive face is symmetry. The presence of symmetry in living organisms reflects their ability to cope with various adverse environmental or genetic factors, thus a symmetrical face signals the hidden qualities of the organism. Despite the evolutionary basis for the attractiveness of facial symmetry, studies that have examined it have yielded diverse results. One reason may lie in the fact that the symmetrical stimulus faces are often composites that are created by using the mirror image of one, which can lead to contradictory outcomes. When evaluating human faces, the dominance of the left visual field (as a reflection of brain lateralisation functions) comes into play, which may modify the attractiveness of the composite depending on whether it was created as a left-sided mirror image (using the left half of the face) or a right-sided mirror image (using the right half of the face). The study aims to evaluate the attractiveness of left-sided and right-sided symmetrical facial composites and how the evaluator's visual field dominance affects the assessed attractiveness. The research was conducted on a sample of 1,921 participants aged from 15 to 77 (M = 23.57; SD = 9.52); 60.7% women using computerised facial composites in quasi-experimental research design. The results show that left-sided facial composites are significantly (p<0.001) more attractive than right-sided, for both female and male faces. Furthermore, it is noted that visual field dominance is not related to the type (left-sided vs. right-sided) of symmetry or the evaluation of its attractiveness – individuals with dominant left visual fields as well as those with dominant right visual fields universally rate the left-sided composite as significantly more attractive than the right-sided composite.
Analysis of the Impact of Foreign Direct Investment on the Integration of the Automotive Industry of Iran into Global Production Networks
Authors: Mostofian Bahareh
Published: December 2023

Foreign Direct Investment (FDI) has long been recognized as a crucial driver of economic growth and development in less-developed countries and their integration into Global Production Networks (GPNs). FDI not only brings capital from the core countries but also technology, innovation, and know-how knowledge that can upgrade the capabilities of host automotive industries. On the other hand, FDI can also have negative impacts on host countries if it leads to significant import dependency. In the case of the Iranian automotive sector, the industry greatly benefited from FDI, with Western carmakers dominating the market. Over time, various types of know-how knowledge, including joint ventures (JVs), trade licenses, and technical assistance, have been provided, helping Iran upgrade its automotive industry. While after the severe geopolitical obstacles imposed by both the EU and the U.S., the industry became over-reliant on the car and spare parts imports, and the lack of emphasis on knowledge transfer further affected the growth and development of the Iranian automotive sector. To address these challenges, current research has adopted a descriptive-analytical methodology to illustrate the gradual changes occurred with foreign suppliers through FDI. The research finding shows that after the two-phase imposed sanctions, the detrimental linkages created by overreliance on the car and spare parts imports without any industrial upgrading negatively affected the growth and development of the national and assembled products of the Iranian automotive sector.
Exploring Headteachers' Struggles in Overseeing Kindergarten Education at Basic Schools: An In-Depth Study in Awutu Senya East Municipality
Authors: Badu Seth , Woode-Eshun Anthony , Mohammed Ali Yaaku Sumani , Assan Eric , Owusu Tracy
Published: December 2023

This study explored the the challenges facing headteachers in managing kindergarten schools in the Awutu Senya East Municipality. Using a descriptive survey design, a structured questionnaire was administered to 76 headteachers who were selected through census technique. A five-point Likert scale questionnaire was used to collect data from the respondents. Descriptive statistics (mean and standard deviation) were used to analyse the data obtained. The data highlighted several challenges facing headteachers in managing kindergarten level of basic schools, and these included large class size, inadequate teaching and learning resources, inadequate support from PTA and SMC, lack of professional training in supervision and management for headteachers, lack of co-operation among members of staff among others. It, therefore, recommended that the the Ministry of Education should ensure timely release of capitation grants to support the provision of the needed school resources and upgrade of teaching personnel. Also, there should be a liaison with corporate organisations who as part of the corporate social responsibility can attend to some pertinent needs of the school as identified in the various encountered challenges by headteachers.
Dubai Expo 2020’s Impact on the United Arab Emirates Brand: A Quantitative Analysis of American and European Media Companies
Authors: Medina Aguerrebere Pablo , Burgess Scott , Chadli Lakhdar , Medina Eva
Published: December 2023

Countries implement corporate communication initiatives to improve their international relations, achieve business objectives, and strengthen their brands. Nation branding activities are mainly based on international events: sports, culture, and social issues. This paper evaluates the Dubai Expo 2020’s impact on the United Arab Emirates brand. We conducted a literature review about nation branding, and then we resorted to 15 indicators to analyze how the most important newspapers from some of the most influential countries (United States, Russia, France, and Germany) covered this event from a journalistic and corporate communication perspective. Our results proved that 82 articles were published about this topic; on the other hand, the most common criteria respected by these companies were quoting organizers (n=61), using the Expo’s logo (n=45), and the image of a falcon (n=43). We concluded that most media companies focused on facts related to the Expo 2020 and made references to the country’s identity (values, flag, falcon); however, most of them did not include links to the Dubai Expo and UAE public authorities’ websites.
Gender Disparities in E-commerce Adoption Barriers among Entrepreneurs in Sri Lanka
Authors: Gamage Nadeeka Priyadarshani
Published: December 2023

This research study investigates the gender-based differences in e-commerce adoption barriers among entrepreneurs in Sri Lanka. Employing a quantitative research approach, a sample of 460 entrepreneurs from the Hambantota District was selected using proportionate stratified random sampling. Primary data was collected through a validated questionnaire, and data analysis involved statistical techniques such as regression analysis. The findings highlight substantial disparities in the perception of e-commerce adoption barriers between male and female entrepreneurs in Sri Lanka. Female entrepreneurs encounter unique challenges in the realm of e-commerce adoption, underscoring the significant influence of gender on shaping adoption patterns. While both genders identify Lack of awareness and knowledge of e-commerce, Lack of qualified personnel to develop and support e-commerce, and Lack of popularity for online shopping as substantial and persistent barriers, Fear and reluctance to change and Inadequate delivery networks emerge as particularly noteworthy obstacles for female entrepreneurs. These research findings hold implications for the formulation of more effective government policies and strategic initiatives aimed at fostering a dynamic entrepreneurial ecosystem, particularly to empower female entrepreneurs in developing countries.
BOĞAZLARIN HUKUKİ STATÜSÜNE GÖRE YABANCI GEMİLERİN BOĞAZLARDAN GEÇİŞ PRATİKLERİNİN BOĞAZLAR MUHAFIZLIĞI’NCA TATBİKİ (1832-1908)
Authors: ÇEVİK AZAP Pınar
Published: December 2023

1453 yılında İstanbul’un fethedilmesi ve ardından yürütülen genişleme siyaseti kapsamında 1484 yılından itibaren Karadeniz’in tüm sahil şeridine sahip olunması, Osmanlı Devleti’ne boğazlar üzerinde mutlak egemenlik hakkı tanımıştı. Osmanlı Devleti’nin boğazlar üzerindeki bu mutlak egemenlik hakkı, Boğazlar’dan geçiş ve Karadeniz’in deniz ulaşımının tamamıyla Osmanlı Devleti’nin tasarrufunda bulunmasına olanak sağlamaktaydı. Boğazların tüm yabancı devletlerin gemilerine kapalı olması esası üzerine belirlenen bu tasarruf hakkı, XVIII. yüzyılın sonlarına kadar tatbik edilse de Osmanlı Devleti’nin boğazlar üzerindeki bu hakkı, 1798 yılından itibaren yapılan ikili anlaşmalarla zayıflatılmış, 1841 yılından itibaren de çok taraflı antlaşmalarda sınırlandırılmıştı. Yapılan uluslararası antlaşmalarla hukuki statüsü belirlenen boğazlardan yabancı gemilerin geçiş rejimi, Bahr-i Sefid Boğazı Muhafızlığı ve Bahr-i Siyah Boğazı Muhafızlığı ile kontrol edilmekteydi. Her iki boğazlar muhafızlığı bu vazifesini, 1832 yılında müşiriyet olarak tesis edilen Tophane-i Amire Müşiriyeti’ne bağlı olarak yürütmekteydi. Bahr-i Sefid ve Bahr-i Siyah Boğazları Muhafızlığı, hem uluslararası antlaşmalarla belirlenen kaidelere uygun olarak yabancı gemilerin geçiş rejimini tatbik etmekteydi hem de çağın ihtiyacı ve zorunluluğu kapsamında bu geçişler esnasında gemiler üzerinde deniz karantinasını icra etmekteydi. Ayrıca silah, mühimmat, barut gibi patlayıcı maddelerin kaçak bir şekilde boğazlardan geçirilmesine mâni olmak da her iki boğazlar muhafızlığının göreviydi. Bu çalışmanın amacı, 1908 yılında lağvedilene kadar Tophane-i Amire Müşiriyeti’ne bağlı olan Boğazlar Muhafızlığı’nın, yabancı gemilerin boğazlardan geçiş rejimini uygulama pratiklerini incelemektir. Bu amaç doğrultusunda çalışmanın kapsamı, yabancı gemilerin uluslararası antlaşmalarla belirlenen geçiş kaideleri ile bu kaidelerin barış ve savaş zamanlarında Boğazlar Muhafızlığı’nca ne şekilde uygulandığını tespit etmek olacaktır.
Effectiveness of Helmet therapy for infants with moderate to severe positional plagiocephaly
Authors: Kim Jeongho , Kim Jina , Chae Kyu Young
Published: December 2023

Background: The use of helmet treatment for positional plagiocephaly has increased recently; however, its effect is unknown in Korea.Purpose: This study aimed to investigate the effectiveness of helmet therapy and identify its influencing factors.Methods: Ninety pediatric patients diagnosed with moderate to severe positional plagiocephaly received helmet therapy. Severity of moderate to severe positional plagiocephaly was defined as cranial vault asymmetry (CVA) >10 mm or CVA index (CVAI) >6%. Patients were categorized by age, severity, and daily helmet wear. Multiple regression analysis controlled for factors like sex and prematurity. Treatment success was assessed by comparing pre/post-helmet theray CVA and CVAI, considering normalization or decrease to mild plagiocephaly (CVA ≤10 mm or CVAI ≤6%).Results: A total of 90 participants were enrolled (mean age, 5.6±1.6 months; male, 53 [58.9%]). The mean helmet therapy duration was 6.4±2.7 months, while the mean daily wear time was 18.4±2.7 hours. Among the 90 patients, 66 (73.3%) had moderate disease and 24 (26.7%) had severe disease. The mean CVA and CVAI decreased by 6.3±2.7 mm and 4.3%±1.8% after versus before treatment (P<0.001). Treatment was successful in 76 infants (84.4%). The most effective changes in CVA and CVAI were noted in those who began treatment before 9 months of age (6.2±2.5 mm and 5.0%±1.9%, P<0.001), had high compliance (6.2±2.4 mm and 4.9%±1.9%, P<0.001), and had high severity (8.0±2.3 mm and 6.6%±1.7%, P<0.001).Conclusion: Starting helmet treatment before 9 months and wearing it over 15 hours daily yielded better outcomes.
KONSEP KURIKULUM MERDEKA DAN INTEGRASI MEDIA PEMBELAJARAN BERBASIS DIGITAL PADA JENJANG SEKOLAH DASAR
Authors: Durroh Nasihatul Ummah  , Nadlir Nadlir
Published: December 2023

Perkembangan teknologi yang semakin pesat menjadi tantangan baru dalam dunia pendidikan. Perubahan paradigma praktek pembelajaran dari hanya menyajikan informasi bergeser menjadi membekali siswa dengan kemampuan mencari tau, memecahkan masalah, digital literasi dan kreativitas. Perubahan kebijakan kurikulum juga mengakibatkan perubahan model, strategi, metode dan media pembelajaran yang baru. Tujuan dari penelitian ini untuk mendeskripsikan 1) Konsep kurikulum merdeka, 2) Integrasi media pembelajaran berbasis digital pada jenjang sekolah dasar. Penelitian ini menggunakan metode menggunakan kualitatif deskriptif dengan pendekatan library research atau studi pustaka. Pengumpulan data diperoleh dengan mengkaji berbagai literatur yang relevan. Analisis data melalui analisis konten/isi. Hasil penelitian menunjukkan 1) Konsep kurikulum merdeka belajar merupakan konsep hasil dari evaluasi kurikulum 2013 yang memuat a) Pembelajaran terfokus pada materi esensial sehingga terdapat waktu untuk mendalami kompetenasi literasi dan numerasi, b) Pembelajaran berbasis proyek untuk pengembangan keterampilan dan penguatan karakter profil pelajar pancasila. c) Guru diberi kebebasan melakukan diferensiasi dalam pembelajaran sesuai kebutuhan dan kemampuan siswa. 2) Integrasi media pembelajaran berbasis digital dalam kurikulum merdeka terdapat dalam perangkat ajar yang berupa modul ajar, alur tujuan pembelajaran (ATP), serta projek penguatan profil pancasila. Media pembelajaran berbasis digital ini juga tersedia dalam platform digital yang disediakan Kemenristekdikti dan dapat dikembangkan guru dengan menyesuaikan kebutuhan siswa.

 

 Kata kunci: Kurikulum Merdeka, Media Pembelajaran Digital, Sekolah Dasar.
PENERAPAN PROGRAM UNGGULAN RINTISAN BOARDING SCHOOL DALAM MEMBENTUK KARAKTER SISWA MADRASAH IBTIDAIYAH
Authors: Awwaliyah Annisa Fajriatul , Hanik Elya Umi , Anam Syaiful
Published: December 2023

This study aims to clearly determine: 1) The implementation of the Pioneer Boarding School Program in shaping the character of MI NU Miftahul Huda 02 Gebog Kudus students, 2) The success of the Pioneer Boarding School Program in shaping the character of MI NU Miftahul Huda 02 Gebog Kudus students. This research is a qualitative descriptive study conducted using a field research approach, Data collection techniques included interviews, observations, and documentation. The results of the study indicate that The results of the study indicate that: 1) Boarding School Program in shaping the character of students involves several steps, including the planning phase, and then the implementation, The third phase is evaluation. 2) The success of implementing the Pioneer Boarding School Program in shaping the character of MI NU Miftahul Huda 02 Karangmalang Gebog Kudus students lies in integrating moral knowing, moral feeling, and moral behavior in combining academic and religious character education. This program has been successful in integrating academic and religious character education through classroom-based character education and madrasah-based cultural character education, as evidenced by the improvement of students' disciplined, independent, responsible, and environmentally conscious character.
The Hallmarks of Cancer in 2023
Authors: Anderson Lucy
Published: December 2023

CURRENT cancer hallmarks, their capabilities, and potential targeted therapies were the focus of the presentation given by Douglas Hanahan, Ludwig Institute for Cancer Research, Lausanne, Switzerland, at the European Society for Medical Oncology (ESMO) Congress 2023, held in Madrid, Spain. Hanahan began by defining hallmarks as acquired functional capabilities that contribute to the manifestation of the disease, which are a “conceptual framework for rationalising the daunting complexity of cancer.”
Dancing on the Strand: The Adelphi Theatre’s Dance Repertoire, 1840–1860
Authors: Hodgson Amanda
Published: December 2023

Dance was ubiquitous on the early Victorian stage but theatre dance of the period has received little critical attention. Examination of the repertoire of the Adelphi Theatre in London in 1840–1860 shows that dance occurred in a wide range of theatrical contexts including melodrama, farce, extravaganza and burlesque. The Adelphi also specialised in adaptations of Romantic ballets that combined spectacle, narrative, dance and song. In such theatre pieces dance could be not only decorative, but also fully integrated into the structural and thematic contexts in which it was embedded. In The Enchanted Isle, for example, dance makes a suggestive contribution to the political agenda of the play.
Performing for Napoleon: Production Quarrels at the Paris Opéra
Authors: Cazzato Elisa
Published: December 2023

This study addresses the collaboration of the stage designer Ignazio Degotti (1758–1824) with the choreographer Pierre Gardel (1758–1840) in a series of works presented at the Théâtre de l’Opéra in Paris during the Napoleonic administration (1804–1815). Backstage episodes in three key performances demonstrate that although the Opéra was politically crucial to Napoleon, there were practical problems in theatre management on his watch. This study argues that the inadequacy of spaces for artistic creation and a lack of coordination among the creative team were the most pressing issues in this respect.
Role of ovarian suppression in adjuvant treatment of breast cancer
Authors: Ruban M. S. , Karagodina Yu. B. , Bolotina L. V. , Kachmazov A. A. , Kornietskaya A. L. , Savchina V. V. , Evdokimova S. F. , Fedenko A. A.
Published: December 2023

Adjuvant endocrine therapy is an integral component of treatment for resectable luminal breast cancer. Tamoxifen or aromatase inhibitors monotherapy has been the standard of practice for many years. However, recent studies have shown that the addition of ovarian suppression statistically significantly increases survival rates in patients at high risk for recurrence and with poor prognosis factors. In this literature review, we summarized recent data regarding the role of ovarian suppression in adjuvant therapy for hormone-positive breast cancer. Suppression of ovarian function was most effective in young patients (< 35 years) in the premenopausal stage when adverse prognostic factors were present (indications for (neo)adjuvant CT, G3, etc.) The authors noted that using of aromatase inhibitors instead of tamoxifen in this subgroup significantly reduced the risk of breast cancer recurrence. Ovarian suppression, especially in combination with aromatase inhibitors, was accompanied by an increase in the incidence of adverse side effects, particularly osteoporosis and bone fractures, which can be reduced by prescribing adequate accompanying therapy with OMA. The optimal duration of ovarian function suppression has also not been determined, but a two-year course seems optimal, given the results of large clinical trials. In the protocols performed, there was no significant effect of temporary ovarian suppression on the likelihood of subsequent pregnancy.
Results of stereotactic radiation therapy in treatment of patients with T1N0M0 kidney cancer
Authors: Sabelnikova Zh. E. , Sarycheva M. M. , Mozerova E. Ya. , Vazhenin A. V. , Lozhkov A. A.
Published: December 2023

Background. Currently, the main treatment for T1N0M0 kidney cancer is surgery, mainly in the amount of kidney resection. However, not all patients can be operated on, and most often due to the severity of comorbidity, some patients refuse surgery. In such cases, it becomes necessary to search for an acceptable operation of an alternative method of treatment. Such requirements can be met by stereotactic radiotherapy (SBRT), being a non-invasive method of treating renal cell carcinoma.

Purpose. To determine overall survival (OS), local control, and renal toxicity after treatment of T1N0M0 renal cell carcinoma (RCC) with stereotactic radiotherapy.

Material and methods. Since 2011 to 2022 in the Chelyabinsk Regional Clinical Centre of Oncology and Nuclear Medicine, 50 patients with verified RCC underwent SBRT up to 30–45 Grey in three fractions using the CyberKnife. The mean age of the patients was 69.8 years. Primary tumor was diagnosed in 44 cases, recurrence after previous surgical treatment in 6 cases, including one patient with recurrence of cancer of both kidneys. The average tumor volume was 29.1 cm3 .

Results. Median overall survival was not reached as most patients were alive at the time of the study. Indicators of 1-, 3- and 5-year OS are 94.8%, 87.3% and 75.1%, respectively. In 74.5% of cases, according to the RECIST 1.1 criteria, stabilization of the process was recorded 6 months after STLT, in 21.6% of cases – a partial response, in 3.9% – progression of the process. One-year local control – 98%. Renal toxicity occurred in 26% of patients 6 months after radiation therapy, but within a year, kidney function was restored in these patients.

Conclusions. Stereotactic radiation therapy T1N0M0 of kidney cancer in SOD = 30–45 Grey allows to stabilize the tumor process with sufficiently high results of overall survival and local control with low renal toxicity, respectively, can be used in the treatment of inoperable patients with localized renal cell carcinoma.
Optimal choice of neoadjuvant therapy for HER2-positive breast cancer. Analysis of doctors’ preferences in Russian Federation
Authors: Artamonova E. V. , Lubennikova E. V.
Published: December 2023

The development and introduction into widespread practice of anti-HER2 agents has changed the natural course of HER2-positive breast cancer, significantly increasing the chance of cure in early forms and significantly increasing the life expectancy of patients with metastatic disease. The results of clinical trials indicate a significant increase in the frequency of achieving complete pathological regress and improved survival rates when using the combination of trastuzumab + pertuzumab in neoadjuvant therapy for HER2-positive breast cancer, which is reflected in modern national and international guidelines. However, the use of drugs in real clinical practice is associated with a whole range of factors and may differ from standard recommendations. To understand the situation in the Russian Federation, a survey study ‘Therapy of HER2-positive breast cancer’ was conducted. 50 specialists – heads of drug therapy departments and/or their deputies who are directly involved in the development of a treatment plan for patients, were involved in the survey. It allows to reflect the preferences of leading chemotherapists regarding treatment strategies for patients with HER2-positive breast cancer in Russian Federation. This publication highlights the results of a survey on the prescription of neoadjuvant therapy for primary resectable and locally advanced unresectable HER2-positive breast cancer. Most experts prefer to use combinations with pertuzumab. In real clinical practice, 62% of patients receive dual anti-HER2 therapy. In the future, experts are ready to increase the percentage of prescribing pertuzumab for early HER2-positive breast cancer for more 16–20%. Based on the results of large randomized trials, this should improve long-term outcomes in one of the most aggressive forms of breast cancer.
MEŞRUTİYETTEN CUMHURİYETE MUSTAFA KEMAL ATATÜRK ve SPOR
Authors: AYSAL Necdet
Published: December 2023

Sosyal ve Kültürel hayatın dinamiklerinden birisi olan spor, insanın doğa koşulları ile tanışarak ona uyması, doğada egemen olmaya başlaması ve kendini korumak için tek araç olan vücudunu ve adalelerini geliştirmesiyle başlamıştır. Türkiye Cumhuriyeti Devleti’nin kurucusu Gazi Mustafa Kemal Atatürk’ün spora olan ilgisi askeri öğrencilik yıllarında başlamış, izleyici ve uygulayıcı olarak yaşamı boyunca spor faaliyetlerinin içerisinde yer almıştır. Özellikle beden eğitimi, binicilik ve atıcılık dallarındaki başarısı, güreş başta olmak üzere cirit, at yarışları ve deniz sporlarına olan yakın ilgisi nedeniyle, Türk sporunun gelişimine her türlü maddi ve manevi yardımı yapmaktan çekinmemiştir. Sporun gençlik ve geniş halk kitlesi tarafından benimsemesiyle başarıların elde edilebileceğini düşünen Atatürk, tüm okullarda beden eğitimini zorunlu kılmış, zeki, çevik ve ahlaklı gençlerin yetiştirilmesine önem vermiştir. Bu çalışmada, Meşrutiyetten Cumhuriyete spor alanında yaşanan gelişmeler ele alınmış ve süreçte Mustafa Kemal Atatürk’ün Türk sporuna verdiği destek, Söylev ve Demeçler başta olmak üzere belgelere dayalı araştırma eserleri ve ikinci el kaynaklar incelenerek ortaya konulmaya çalışılmıştır.
SISTEM INFORMASI LES PRIVAT KOTA KEDIRI BERBASIS ANDROID
Authors: Fery Sofian Efendi
Published: December 2023

Demanding knowledge Made of things that must be and must be implemented for every human being. One example of the demand for science at official official institutions such as in school. Currently there is no science that exist in schools that can improve the quality of students. Some of the learners at school may not be full-fledged. Lessons are taught in schools. For the exams undertaken the learners need to learn by alternative methods outside the school such as learning to learn or private lessons. Not a few individuals who also provide ease in the form of private lessons, in addition to alternative side jobs to help and improve the potential participants better locked in understanding the lessons in school or to face the school exam. The methods used are methods that still use manual methods, and are not effective in finding target participants and also participants who will choose a location close to home. Therefore, this research has resulted in an information application that allows users to access services and services that exist among the participants of the personal service and the learners. For the development of personal information system applications in cities using android systems still need to improve the security system because the system used is still needed and still needed, but also need to develop some features such as giving the rating on tentor, learners comment feature on tentor and validity period for account tentor or want a date or application.
Sinkronisasi Data Antar Cabang Studi Kasus Aplikasi Perbankan BPR
Authors: Fadelis Sukya
Published: December 2023

Proses migrasi data transaksi perbankan sangatlah penting untuk mendapatkan laporan secara menyeluruh dari proses bisnis yang dijalankan. Pembuatan perangklat lunak sinkronisasi transaksi BPR bank pasar Kediri bertujuan untuk memudahkan kinerja BPR Bank Pasar Kediri. Serta mengganti kegiatan manual yang sebelumnya telah ada. Serta agar data yang diperlukan oleh cabang lain dapat didapatkan dengan sangat cepat dan efisien.

Aplikasi ini dibangun dengan menggunakan Bahasa pemrograman Java dan database PostgreeSQL. Aplikasi ini dapat diakses langsung dari komputer yang telah terinstall aplikasi ini. Dan untuk proses sinkronisasi antar cabang dapat menggunanan jaringan MAN/WAN yang menghubungkan antar database.

Dengan adanya aplikasi ini kinerja BPR Bank Pasar Kediri menjadi lebih cepat, mudah dan efisien. Tidak perlu lagi melakukan proses sinkronisasi secara manual dan menyulitkan, karena semua akan digantikan oleh aplikasi ini.
Sistem Penggajian Pegawai Politeknik Kediri
Authors: Andika Kurnia Adi Pradana  , Wahyuni Sofiana  , Ari Kuswinda
Published: December 2023

Sistem penggajian pegawai Politeknik Kediri dapat dipergunakan sebagai alat bantu dalam melakukan pengelolaan gaji pegawai dan membantu menyediakan informasi mengenai gaji pegawai dengan mudah dan cepat, karena sistem penggajian pegawai Politeknik Kediri ini berbasis web.

Aplikasi sistem penggajian pegawai Politeknik Kediri ini dirancang dan dibuat dengan Bahasa pemrograman PHP dan diakses menggunakan web browser melalui jaringan internet.

Setelah aplikasi ini dibuat, kemudian dilakukan percobaan dan pengkajian melalui beberapa tahapan. Antara lain uji coba aplikasi melalui web borwser komputer.

Dengan adanya sistem penggajian pegawai Politeknik Kediri ini, akan menjadikan kinerja pegawai Politeknik Kediri lebih efisien. Baik pengelolaan data ataupun penyampaian laporan penggajianj pegawai, karena dapat diakses melalui jaringan internet.
Aplikasi Mobile untuk Konsultasi Booking Praktek Dokter
Authors: Andika Hadi  , Ratna Widyastuti  , Ellya Nurfarida
Published: December 2023

Kesehatan adalah suatu keadaan yang sejahtera dari badan, jiwa, dan social yang memungkinkan setiap orang hidup produktif. Salah satu upaya menjaga kesehatan adalah sering berkonsultasi kepada ahli kesehatan terkait kondisi tubuh. Namun dalam kenyataannya, jika tidak didukung dengan memiliki dokter pribadi, kegiatan konsultasi ke dokter ini menjadi tidak mudah. Masalah lain yang sering ditemui pasien adalah ketika akan berkonsultasi di tempat praktik dokter, pasien sering dipersulit dengan antrian dan proses booking. Untuk mengatasi hal ini, para pakar teknologi sudah beberapa kali membagun sistem online yang bertujuan untuk konsultasi kesehatan secara gratis. Namun belum ditemui sistem yang mampu meberikan fitur konsultasi chatting online sekaligus memesan (booking) praktek pada suatu waktu. Oleh karena itu penelitian ini bertujuan untuk membangun sebuah aplikasi mobile yang dapat membantu masyarakat berkonsultasi dengan dokter melalui aplikasi chatting serta dapat memesan waktu untuk berkonsultasi secara langsung di tempat praktik. Aplikasi yang dibangun dalam penelitian dapat digunakan oleh empat pengguna yaitu admin, dokter, member pasien, dan pengunjung. Aplikasi ini memiliki fitur antara lain admin dapat mengolah artikel kesehatan, member pasien dapat melakukan pendaftaran, berkonsultasi personal dengan dokter, dan berkonsultasi dalam grup. Dalam aplikasi ini juga disediakan fitur untuk booking praktek dokter. Aplikasi web mobile ini dibangun dengan menggunakan bahasa pemrograman PHP dan framework JQuery Mobile.
Rancang Bangun Situs Forum Komunitas Perfilman Berbasis CodeIgniter
Authors: Wendy Adnan Febianto  , Andika Kurnia Adi Pradana  , Abidatul Izzah
Published: December 2023

Film merupakan media komunikasi yang bersifat audio visual untuk menyampaikan suatu pesan kepada sekelompok orang yang berkumpul di suatu tempat tertentu. Saat ini penggemar film disulitkan dengan jadwal pemutaran film dan informasi tentang film terbaru. Oleh karena itu perlu dirancang dan dibuat sebuah situs forum komunitas perfilman berbasis web menggunakan Codeigniter dan Bootstrap. Pembuatan situs forum komunitas perfilman berbasis web menggunakan Codeigniter dan Bootstrap menggunakan metode pengamatan pada aplikasi serupa di forum komunitas maya film lain, buku panduan tentang CSS Bootsrtrap, Framework Codeigniter dan pencarian data di internet. Perancangan forum komunitas maya berbasis web menggunakan Codeigniter dan Bootstrap berhasil dibuat menggunakan DFD dan dibangun menggunakan Framework Codeigniter dan CSS Bootstrap. Situs forum komunitas perfilman berbasis web menggunakan Codeigniter dan Bootstrap ini memiliki tiga pengguna yaitu admin, member dan pengunjung. Aplikasi admin memiliki fitur menambah, mengubah dan menghapus slideshow, jadwal tayang, berita, topik dan video. Aplikasi member memiliki fitur menambah, mengubah dan menghapus tread, pesan, tentang dan komentar. Aplikasi pengunjung memiliki fitur melihat diskusi, forum film, berita, video trailer, jadwal tayang dan registrasi jika ingin jadi member. Pada aplikasi ini sistem belum menyediakan rating bintang, tambah teman dan chatting, akan lebih baik apabila pada aplikasi ini ditambahkan rating bintang, tambah teman dan chatting.
Sistem Informasi Visualisasi Tingkat Produksi Mineral Dan Batuan Berbasis GIS
Authors: Toga Aldila Cinderatama
Published: December 2023

Mineral dalam tanah adalah sebagian besar hasil perombakan dan pelapukan yang terjadi pada permukaan bumi. Mineral dibagi menjadi 2, yaitu mineral logam dan non-logam. Selain mineral, terdapat juga potensi pertambangan berupa batuan. Potensi pertambangan berbahan mineral dalam tanah dan batuan ini dimiliki oleh beberapa wilayah di Indonesia, salah satunya Kabupaten Kediri. Potensi tersebut tidak banyak diketahui oleh masyarakat, sehingga perlu dibuat sebuah sistem informasi yang dapat menampilkan infromasi potensi tersebut, yang diharapkan investor mau berinvestasi ke daerah tersebut dan perekonomian masyarakat meningkat. Maka, sistem yang akan dibuat adalah sebuah âSistem Informasi Visualisasi Tingkat Produksi Mineral Dan Batuan Berbasis GISâ. Sistem tersebut dapat memberikan informasi geografis tentang daerah mana saja yang memiliki tingkat produksi mineral dan batuan yang bervolume tinggi atau rendah. Metodologi dalam penelitian ini ditempuh dalam beberapa langkah, yakni pengumpulan data dengan studi literatur dan wawancara, perencanaan kebutuhan untuk menentukan spesifikasi sistem yang akan dibuat, desain, implementasi, dan pengujian untuk menjadi aplikasi yang sesungguhnya. Berdasarkan metodologi yang ditempuh dan langkah-langkah tersebut. Sistem informasi tersebut diimplementasikan menggunakan bahasa pemrograman web HTML, PHP, menggunakan framework Codeigniter dan Mysql sebagai basis data. Sistem Informasi Visualisasi Tingkat Produksi Mineral Dan Batuan Berbasis GIS dapat menampilkan informasi kandungan mineral dan batuan berupa peta dan tabel. Sistem informasi ini juga dapat menampilkan hasil eksplorasi dan berita tentang pertambangan pada halaman yang berbeda. Untuk penilitian selanjutnya sistem informasi tersebut dapat diperbaiki pada desain tampilan dan penambahan fitur ataupun penambahan daerah atau juga bisa di buat dalam basis Android Kata kunci : mineral, pertambangan, GIS.
Sistem Monitoring Keuangan Perusahaan Kreditur
Authors: Andika Kurnia Adi Pradana  , Abidatul Izzah
Published: December 2023

Dalam kegiatan ekonomi, istilah kreditur dan debitur sudah akrab didengar. Seiring dengan meningkatnya kegiatan pembangunan, meningkat pula kebutuhan terhadap pendanaan. Sebagian besar dana yang diperlukan untuk memenuhi kebutuhan diperoleh melalui kegiatan pinjam-meminjam. Perolehan pendanaan tersebut salah satunya adalah melalui jasa perbankan, yaitu melalui kredit yang diberikan oleh pihak Bank atau melalui jasa lembaga pembiayaan lainnya. Ada baiknya jika bank diberi wewenang untuk mengetahui perkembangan ekonomi seperti status rugi dan laba yang dicapaiperusahaan dalam sekian bulan. Dengan demikian, bank akan dapat mempertimbangkan apakah pengajuan kredit selanjutnya dapat dilanjutkan. Oleh karena itu, penelitian ini bertujuan untuk membangun sebuah sistem yang dapat mengawasi pihak debitur dalam melakukan transaksi pinjam-meminjam. Sistem yang dikembangkan akan berbasis web services. Sistem monitoring keuangan perusahaan kreditur yang dibangun dapat diakses menggunakan web services oleh bank selaku pemberi kredit dimana data keuangan perusahaan dikirim dari sistem yang telah tersedia oleh masing-masing perusahaan. Pengujian sistem dilakukan dengan menguji fitur-fitur yang tersedia pada sistem yakni admin bank dapat login sistem, melihat daftar perusahaankreditur, memperoleh data laporan keuangan dari setiap perusahaan kreditur menggunakan teknologi web service secara periodik, dan melihat laporan rekapitulasi rugi/laba yang diperoleh perusahaan kreditur selama interval waktu yang diinginkan.
Proximal femoral bionic nail—a novel internal fixation system for the treatment of femoral neck fractures: a finite element analysis
Authors: Ding Kai , Zhu Yanbin , Zhang Yifan , Li Yonglong , Wang Haicheng , Li Jiaxing , Chen Wei , Zhang Qi , Zhang Yingze
Published: December 2023

Introduction: Currently, cannulated screws (CSs) and dynamic hip screws (DHSs) are widely used for the treatment of femoral neck fractures, but the postoperative complications associated with these internal fixations remain high. In response to this challenge, our team proposes a new approach involving triangular-supported fixation and the development of the proximal femoral bionic nail (PFBN). The primary objective of this study is to investigate the biomechanical differences among CSs, DHSs, and the PFBN in their capacity to stabilize femoral neck fractures.

Methods: A normal proximal femur model was constructed according to the CT data of a normal healthy adult. A femoral neck fracture model was constructed and fixed with CSs, DHSs, and the PFBN to simulate the fracture fixation model. Abaqus 6.14 software was used to compare the biomechanical characters of the three fracture fixation models.

Results: The maximum stresses and displacements of the normal proximal femur were 45.35 MPa and 2.83 mm, respectively. Under axial loading, the PFBN was more effective than DHSs and CSs in improving the stress concentration of the internal fixation and reducing the peak values of von Mises stress, maximum principal stress, and minimum principal stress. The PFBN fixation model exhibits superior overall and fracture section stability in comparison to both the DHS fixation model and the CS fixation model under axial loading. Notably, the maximum stress and peak displacement of the PFBN and bone were lower than those of the DHS and CS fixation models under bending and torsional loading.

Conclusion: The PFBN shows considerable improvement in reducing stress concentration, propagating stress, and enhancing the overall stability in the femoral neck fracture fixation model compared to DHSs and CSs. These enhancements more closely correspond to the tissue structure and biomechanical characteristics of the proximal femur, demonstrating that the PFBN has great potential for therapeutic purposes in treating femoral neck fractures.
Development of a biomolecular approach to identify sperm functions and fertility using sperm RNAs
Authors: Pang Won-Ki , Park Yoo-Jin , Pang Myung-Geol
Published: December 2023

Infertility affects a significant percentage of couples worldwide, and male factors contribute significantly to this problem. Traditional assessments of male fertility rely primarily on parameters such as sperm motility, morphology, viability, and concentration. However, these metrics often do not provide a comprehensive understanding of sperm function, which is critical not only for fertilization but also for successful embryo development. Herein, we used porcine spermatozoa as a model to investigate the potential of sperm RNA markers in assessing various aspects of sperm function from motility to fertility. Using artificial insemination, we evaluated male fertility based on the litter size of sows inseminated with sperm from 20 boars. In addition, we measured parameters such as weaning rate, death births, live births, and mummy births. Sperm functional parameters, including motility and kinematics, were assessed before and after in vitro capacitation. Finally, correlations between various sperm functional parameters and sperm RNA markers were explored. Our results revealed interesting relationships between sperm functional parameters. While motility and kinematics were correlated, they were not correlated with sperm capacitation status. Surprisingly, no significant correlations were found between these parameters and male fertility. However, specific parameters of sperm capacitation status after in vitro capacitation were correlated with weaning rate and live births, highlighting their importance in predicting successful fertilization. Further analysis of sperm RNA markers identified genes related to male fertility, including IZUMO1, known for its role in sperm-egg fusion. These genes showed correlations with motility, capacitation, and fertilization parameters, shedding light on their potential roles in sperm function. In conclusion, our study demonstrates that sperm RNA markers hold promise for the diagnosis and prognosis of various aspects of sperm function, providing valuable insights into male infertility. These markers may serve as diagnostic tools to improve our understanding of male fertility problems, ultimately benefiting couples struggling with infertility.