bluuebunny/crossref_metadata_2025 huggingface dataset:
Data Supplement from Kinase Domain Activation of FGFR2 Yields High-Grade Lung Adenocarcinoma Sensitive to a Pan-FGFR Inhibitor in a Mouse Model of NSCLC
Authors: Tchaicha Jeremy H. , Akbay Esra A. , Altabef Abigail , Mikse Oliver R. , Kikuchi Eiki , Rhee Kevin , Liao Rachel G. , Bronson Roderick T. , Sholl Lynette M. , Meyerson Matthew , Hammerman Peter S. , Wong Kwok-Kin
Published: March 2023

Supplemental Table 1. Patients (SqCC and AdC) with FGFR2 mutations.
Supplementary Figure S3 from Endothelin A Receptor/β-Arrestin Signaling to the Wnt Pathway Renders Ovarian Cancer Cells Resistant to Chemotherapy
Authors: Rosanò Laura , Cianfrocca Roberta , Tocci Piera , Spinella Francesca , Di Castro Valeriana , Caprara Valentina , Semprucci Elisa , Ferrandina Gabriella , Natali Pier Giorgio , Bagnato Anna
Published: March 2023

Supplementary Figure S3. Chemoresistant EOC cells are able to invade through ETAR.
Supplementary Figure 2 from Critical Tumor Suppressor Function Mediated by Epithelial Mig-6 in Endometrial Cancer
Authors: Kim Tae Hoon , Lee Dong-Kee , Cho Sung-Nam , Orvis Grant D. , Behringer Richard R. , Lydon John P. , Ku Bon Jeong , McCampbell Adrienne S. , Broaddus Russell R. , Jeong Jae-Wook
Published: March 2023

PDF file - 308K, Steroid hormone-dependent formation of endometrial cancer induced the uteri of Wnt7acre+ Mig-6f/f mice.
Supplementary Figure 6 from Cysteine Catabolism: A Novel Metabolic Pathway Contributing to Glioblastoma Growth
Authors: Prabhu Antony , Sarcar Bhaswati , Kahali Soumen , Yuan Zhigang , Johnson Joseph J. , Adam Klaus-Peter , Kensicki Elizabeth , Chinnaiyan Prakash
Published: March 2023

PDF file - 89K, The influence of attenuating CDO expression in vitro.
Supplementary Figure 5 from Cysteine Catabolism: A Novel Metabolic Pathway Contributing to Glioblastoma Growth
Authors: Prabhu Antony , Sarcar Bhaswati , Kahali Soumen , Yuan Zhigang , Johnson Joseph J. , Adam Klaus-Peter , Kensicki Elizabeth , Chinnaiyan Prakash
Published: March 2023

PDF file - 131K, (A) CSA attenuates oxygen consumption rate (OCR) in U251 stable CDO knockdown cells. (B) DCA increases OCR in U251 cells. (C) Immunofluorescent analysis of mitochondrial potential using the JC-1 assay. (D) CSA does not influence OCR in isolated mitochondria.
Supplementary Figure 3 from Cysteine Catabolism: A Novel Metabolic Pathway Contributing to Glioblastoma Growth
Authors: Prabhu Antony , Sarcar Bhaswati , Kahali Soumen , Yuan Zhigang , Johnson Joseph J. , Adam Klaus-Peter , Kensicki Elizabeth , Chinnaiyan Prakash
Published: March 2023

PDF file - 94K, CSA modulates mitochondrial function in GBM cells.
Supplementary Figure 2 from Cysteine Catabolism: A Novel Metabolic Pathway Contributing to Glioblastoma Growth
Authors: Prabhu Antony , Sarcar Bhaswati , Kahali Soumen , Yuan Zhigang , Johnson Joseph J. , Adam Klaus-Peter , Kensicki Elizabeth , Chinnaiyan Prakash
Published: March 2023

PDF file - 56K, CDO1 expression in Grade II-IV glioma determined by western blot.
Supplementary Methods from SIRT1 Limits the Function and Fate of Myeloid-Derived Suppressor Cells in Tumors by Orchestrating HIF-1α–Dependent Glycolysis
Authors: Liu Guangwei , Bi Yujing , Shen Bo , Yang Hui , Zhang Yan , Wang Xiao , Liu Huanrong , Lu Yun , Liao Jiongbo , Chen Xi , Chu Yiwei
Published: March 2023

PDF file - 69K
Supplementary Table 1 from Survival in Patients with High-Risk Prostate Cancer Is Predicted by miR-221, Which Regulates Proliferation, Apoptosis, and Invasion of Prostate Cancer Cells by Inhibiting IRF2 and SOCS3
Authors: Kneitz Burkhard , Krebs Markus , Kalogirou Charis , Schubert Maria , Joniau Steven , van Poppel Hein , Lerut Evelyne , Kneitz Susanne , Scholz Claus Jürgen , Ströbel Philipp , Gessler Manfred , Riedmiller Hubertus , Spahn Martin
Published: March 2023

PDF file - 11K, Preoperative and postoperative patients characteristics.
Supplementary Figure Legends from Inhibition of miR-17 and miR-20a by Oridonin Triggers Apoptosis and Reverses Chemoresistance by Derepressing BIM-S
Authors: Weng Hengyou , Huang Huilin , Dong Bowen , Zhao Panpan , Zhou Hui , Qu Lianghu
Published: March 2023

PDF file - 86KB
Supplementary Methods from A Systems Biology Approach Identifies Effective Tumor–Stroma Common Targets for Oral Squamous Cell Carcinoma
Authors: Meng Wenxia , Wu Yun , He Xin , Liu Chuanxia , Gao Qinghong , Ge Lin , Wu Lanyan , Liu Ying , Guo Yiqing , Li Xiaoyu , Liu Yurong , Chen Sixiu , Kong Xiangli , Liang Zhi , Zhou Hongmei
Published: March 2023

PDF file - 85K
Supplementary Figure 3 from Universal Marker and Detection Tool for Human Sarcoma Circulating Tumor Cells
Authors: Satelli Arun , Mitra Abhisek , Cutrera Jeffry J. , Devarie Marcos , Xia Xueqing , Ingram Davis R. , Dibra Denada , Somaiah Neeta , Torres Keila E. , Ravi Vinod , Ludwig Joseph A. , Kleinerman Eugenie S. , Li Shulin
Published: March 2023

PDF file - 660KB, Detection of CD31, an endothelial cell marker on CTC.
Supplementary Figures 1 - 4 from A Systems Biology Approach Identifies Effective Tumor–Stroma Common Targets for Oral Squamous Cell Carcinoma
Authors: Meng Wenxia , Wu Yun , He Xin , Liu Chuanxia , Gao Qinghong , Ge Lin , Wu Lanyan , Liu Ying , Guo Yiqing , Li Xiaoyu , Liu Yurong , Chen Sixiu , Kong Xiangli , Liang Zhi , Zhou Hongmei
Published: March 2023

PDF file - 1150K, From cancer signature genes to EMCT seed predictions (S1); Immunohistochemistry was used to distinguish NFs and CAFs with antibodies targeting cytokeratin (CK), vimentin (VIM), and alpha-smooth muscle actin (alpha-SMA) (x100) (S2); Expression of TbetaRIII in OSCC cells and CAFs after retroviral transfection (S3); Examination of TbetaRIII and vimentin expression in sections of different types of HSC-2 tumors (S4).
Supplementary Table 4 from YAP-Induced Resistance of Cancer Cells to Antitubulin Drugs Is Modulated by a Hippo-Independent Pathway
Authors: Zhao Yulei , Khanal Prem , Savage Paul , She Yi-Min , Cyr Terry D. , Yang Xiaolong
Published: March 2023

PDF file - 27KB, Comparison of positions for YAP phosphorylation sites in different YAP isoforms.
Supplementary Movie 6 from Androgen Receptor Splice Variants Determine Taxane Sensitivity in Prostate Cancer
Authors: Thadani-Mulero Maria , Portella Luigi , Sun Shihua , Sung Matthew , Matov Alexandre , Vessella Robert L. , Corey Eva , Nanus David M. , Plymate Stephen R. , Giannakakou Paraskevi
Published: March 2023

AVI file - 481KB, Dynamics of ARv7 variant nuclear accumulation in cells treated with 1nM TXT.
Supplementary Materials and Methods from NUP98 Fusion Oncoproteins Promote Aneuploidy by Attenuating the Mitotic Spindle Checkpoint
Authors: Salsi Valentina , Ferrari Silvia , Gorello Paolo , Fantini Sebastian , Chiavolelli Francesca , Mecucci Cristina , Zappavigna Vincenzo
Published: March 2023

PDF - 27K, Supplementary Materials and Methods.
Supplementary Figure 3 from Androgen Receptor Splice Variants Determine Taxane Sensitivity in Prostate Cancer
Authors: Thadani-Mulero Maria , Portella Luigi , Sun Shihua , Sung Matthew , Matov Alexandre , Vessella Robert L. , Corey Eva , Nanus David M. , Plymate Stephen R. , Giannakakou Paraskevi
Published: March 2023

PDF file - 182KB, R1881 treatment in M12 cells transfected with ARv567 and ARv7 does not increase AR-variant nuclear accumulation.
Supplementary Figure Legends from NUP98 Fusion Oncoproteins Promote Aneuploidy by Attenuating the Mitotic Spindle Checkpoint
Authors: Salsi Valentina , Ferrari Silvia , Gorello Paolo , Fantini Sebastian , Chiavolelli Francesca , Mecucci Cristina , Zappavigna Vincenzo
Published: March 2023

PDF - 77K, Legends to Supplementary Figures
Supplementary Figure 2 from NUP98 Fusion Oncoproteins Promote Aneuploidy by Attenuating the Mitotic Spindle Checkpoint
Authors: Salsi Valentina , Ferrari Silvia , Gorello Paolo , Fantini Sebastian , Chiavolelli Francesca , Mecucci Cristina , Zappavigna Vincenzo
Published: March 2023

PDF - 1450K, Supplementary Figure 2. Proteasome inhibition rescues NUP98-fusions effects on Securin and Cyclin B degradation. Western blot analysis showing securin (SEC) and cyclin B (CCNB1) levels in HEK293 cells transfected with the indicated constructs after treatment with Nocodazole or Nocodazole and the proteasome inhibitor MG132 for 24 hours. An increase of CCNB1 levels can be appreciated in control cells following MG132 treatment as the result of efficient proteasome inactivation. Anti-betaactin antibody (betaACT) was used as a loading control.
Supplementary Figure 4 from Adenosine-to-Inosine RNA Editing Mediated by ADARs in Esophageal Squamous Cell Carcinoma
Authors: Qin Yan-Ru , Qiao Jun-Jing , Chan Tim Hon Man , Zhu Ying-Hui , Li Fang-Fang , Liu Haibo , Fei Jing , Li Yan , Guan Xin-Yuan , Chen Leilei
Published: March 2023

PDF file - 2499K, A, Western blot analyses showing expression of AZIN1 protein in the indicated cell lines. β-actin was the loading control. B, Quantification of cells from the indicated cells that migrated through the PET-membrane or invaded through the Matrigel-coated membrane.
Supplementary Figure 2 from Adenosine-to-Inosine RNA Editing Mediated by ADARs in Esophageal Squamous Cell Carcinoma
Authors: Qin Yan-Ru , Qiao Jun-Jing , Chan Tim Hon Man , Zhu Ying-Hui , Li Fang-Fang , Liu Haibo , Fei Jing , Li Yan , Guan Xin-Yuan , Chen Leilei
Published: March 2023

PDF file - 39K, Correlation between the expression level of ADAR1 and the editing level of AZIN1 (left panel) or FLNB (right panel) among nine ESCC cell lines.
Supplementary Figure 1 from Adenosine-to-Inosine RNA Editing Mediated by ADARs in Esophageal Squamous Cell Carcinoma
Authors: Qin Yan-Ru , Qiao Jun-Jing , Chan Tim Hon Man , Zhu Ying-Hui , Li Fang-Fang , Liu Haibo , Fei Jing , Li Yan , Guan Xin-Yuan , Chen Leilei
Published: March 2023

PDF file - 375K, The relative ADAR1 expression level in nine ESCC cell lines, as detected by QPCR.
Supplementary Figure 8 from β-Catenin Inhibitor ICAT Modulates the Invasive Motility of Melanoma Cells
Authors: Domingues Mélanie J. , Rambow Florian , Job Bastien , Papon Laura , Liu Wanguo , Larue Lionel , Bonaventure Jacky
Published: March 2023

PDF file - 143K, Un-cropped immunoblot images. Original images used to generate panels in Figures 1, 2, 3, 4, and 5.
Supplementary Figures 1 - 7 from miR-28-5p Promotes Chromosomal Instability in VHL-Associated Cancers by Inhibiting Mad2 Translation
Authors: Hell Michael P. , Thoma Claudio R. , Fankhauser Niklaus , Christinat Yann , Weber Thomas C. , Krek Wilhelm
Published: March 2023

PDF file - 264KB, Suppl. Fig. 1: Mad2 mRNA translation is specifically reduced upon pVHL knockdown. Suppl. Fig. 2: miR-28-5p targets specific sequences in the Mad2 3'UTR. Suppl. Fig. 3: Overexpression of miR-28-5p induces features of aneuploidy. Suppl. Fig. 4: Inhibition of miR-28-5p affects Mad2 at the post-transcriptional level through the Mad2 3'UTR. Suppl. Fig. 5: pVHL controls Mad2 levels via regulating miR-28. Suppl. Fig. 6: Assessment of miR-28-5p status and aneuploidy features in kidney-specific Vhl knockout mice. Suppl. Fig. 7: Analysis of miR-28-5p and aneuploidy levels in ccRCC patient specimen.
Supplementary Figure 1 from ASC-J9 Suppresses Renal Cell Carcinoma Progression by Targeting an Androgen Receptor–Dependent HIF2α/VEGF Signaling Pathway
Authors: He Dalin , Li Lei , Zhu Guodong , Liang Liang , Guan Zhenfeng , Chang Luke , Chen Yuan , Yeh Shuyuan , Chang Chawnshang
Published: March 2023

PDF file - 1326K, Figure. S1. Activation of AR signaling contributes to RCC cells migration, invasion and proliferation.
Supplementary Figure 2 from Tumor Suppressor Alterations Cooperate to Drive Aggressive Mesotheliomas with Enriched Cancer Stem Cells via a p53–miR-34a–c-Met Axis
Authors: Menges Craig W. , Kadariya Yuwaraj , Altomare Deborah , Talarchek Jacqueline , Neumann-Domer Erin , Wu Yue , Xiao Guang-Hui , Shapiro Irina M. , Kolev Vihren N. , Pachter Jonathan A. , Klein-Szanto Andres J. , Testa Joseph R.
Published: March 2023

PDF - 939K, Spheroids and metastatic MM tumors harbor CSC populations. A) Tumor spheroids from Nf2 (+/-);p16/p19 (+/-) mice stained for Oct 3/4 and Nanog. B) Metastatic tumors from the experimental lung metastasis assay stained for CSC markers beta-catenin, Nanog, Oct 3/4 and Sox2.
Supplementary Materials and Methods, Figures 1 - 10, Tables 1 - 4 from Noninvasive Urinary Metabolomic Profiling Identifies Diagnostic and Prognostic Markers in Lung Cancer
Authors: Mathé Ewy A. , Patterson Andrew D. , Haznadar Majda , Manna Soumen K. , Krausz Kristopher W. , Bowman Elise D. , Shields Peter G. , Idle Jeffrey R. , Smith Philip B. , Anami Katsuhiro , Kazandjian Dickran G. , Hatzakis Emmanuel , Gonzalez Frank J. , Harris Curtis C.
Published: March 2023

PDF file - 1526KB, Supplementary Table 1 shows random forest analysis results for predictions of lung cancer status in the training set. Supplementary Table 2 shows associations with survival in the training set when the top four predictive metabolites are combined in all cases. Supplementary Table 3 shows associations with survival in the training set, stratified by self-reported race. Supplementary Table 4 shows intraclass correlation coefficients in the quantitated subset. Supplementary Figure 1 depicts workflow of the classification analysis. Supplementary Figure 2 depicts quality control assessment in the training set. Supplementary Figure 3 shows predictions of smoking status in the training set determined by random forest analysis and abundances of tobacco-related metabolites. Supplementary Figure 4 shows overlap of metabolites predictive of lung cancer status in the training set based on random forest analysis, stratified by gender, race and smoking status. Supplementary Figure 5 shows fragmentation patterns of top four predictive metabolites determined by tandem mass spectrometry. Supplementary Figure 6 depicts identification of creatine riboside by NMR. Supplementary Figure 7 shows diurnal effects on top four predictive metabolites. Supplementary Figure 8 shows top four predictive metabolite abundances stratified by smoking status. Supplementary Figure 9 shows Kaplan-Meier survival estimates in the training set depicted for the top four predictive metabolites in stages I-II and their combination. Supplementary Figure 10 shows metabolite abundances stratified by chemotherapy/radiation status and surgery status.
Supplemental Figure 3 from Mitochondrial MKP1 Is a Target for Therapy-Resistant HER2-Positive Breast Cancer Cells
Authors: Candas Demet , Lu Chung-Ling , Fan Ming , Chuang Frank Y.S. , Sweeney Colleen , Borowsky Alexander D. , Li Jian Jian
Published: March 2023

Supplemental Figure 3. Cell viability following MKP1 siRNA treatment
Supplementary Table S2 from TGFβ Receptor 1: An Immune Susceptibility Gene in HPV-Associated Cancer
Authors: Levovitz Chaya , Chen Dan , Ivansson Emma , Gyllensten Ulf , Finnigan John P. , Alshawish Sara , Zhang Weijia , Schadt Eric E. , Posner Marshal R. , Genden Eric M. , Boffetta Paolo , Sikora Andrew G.
Published: March 2023

Supplementary Table S2. Immune genes in the HPV+ analysis
Supplementary Table 2 from Function-Blocking ERBB3 Antibody Inhibits the Adaptive Response to RAF Inhibitor
Authors: Kugel Curtis H. , Hartsough Edward J. , Davies Michael A. , Setiady Yulius Y. , Aplin Andrew E.
Published: March 2023

PDF file - 378K, 1205 and A375 RPPA Cluster analysis.
Supplementary Figure Legends from Cellular Factors Promoting Resistance to Effective Treatment of Glioma with Oncolytic Myxoma Virus
Authors: Zemp Franz J. , McKenzie Brienne A. , Lun Xueqing , Reilly Karlyne M. , McFadden Grant , Yong V. Wee , Forsyth Peter A.
Published: March 2023

Legend for Supplementary Figures S1-S10.
Supplementary Figure Legends from CCR5 Receptor Antagonists Block Metastasis to Bone of v-Src Oncogene–Transformed Metastatic Prostate Cancer Cell Lines
Authors: Sicoli Daniela , Jiao Xuanmao , Ju Xiaoming , Velasco-Velazquez Marco , Ertel Adam , Addya Sankar , Li Zhiping , Andò Sebastiano , Fatatis Alessandro , Paudyal Bishnuhari , Cristofanilli Massimo , Thakur Mathew L. , Lisanti Michael P. , Pestell Richard G.
Published: March 2023

Legend for Supplementary Figures S1-S12.
Supplementary Figure S2 from Selective In Vivo Imaging of Syngeneic, Spontaneous, and Xenograft Tumors Using a Novel Tumor Cell–Specific Hsp70 Peptide-Based Probe
Authors: Stangl Stefan , Varga Julia , Freysoldt Bianca , Trajkovic-Arsic Marija , Siveke Jens T. , Greten Florian R. , Ntziachristos Vasilis , Multhoff Gabriele
Published: March 2023

Supplemental Figures S2A,B: Discrimination of TPP[Cy5.5] and CP[DL750] fluorescence using NIRF imaging system. Figure S2A: unspecific excitation of CP[DL750] and TPP[Cy5.5]. Figure S2B: Tumor to background ratio (TBR) of primary lesions and lung metastases using control peptides CP[DL750] and CP[Cy5.5]
Supplemental Table 1 and Figures S1-6 from Densely Ionizing Radiation Acts via the Microenvironment to Promote Aggressive Trp53-Null Mammary Carcinomas
Authors: Illa-Bochaca Irineu , Ouyang Haoxu , Tang Jonathan , Sebastiano Christopher , Mao Jian-Hua , Costes Sylvain V. , Demaria Sandra , Barcellos-Hoff Mary Helen
Published: March 2023

Supplemental Table 1 and Figures S1-6. Table S1: tumor features. Fig. S1. Tumor growth curves from different irradiation group. Fig. S2. Host irradiation promotes ER-negative tumor growth. Fig. S3. Unsupervised hierarchical clustering of mouse tumors based on SD of 1.0. Fig. S4. Highly expressed genes in mammary stem cell are preferentially underexpressed in K18 compared to K14/18 tumor. Fig. S5. K14/18-IHPsi is negatively associated with MaSC signature. Fig. S6. Host irradiation exerts more robust effects on gene expression profile in ER-negative(ER-neg) than ER-positive(ER-pos) tumors.
Supplementary Methods from A Regulatory Loop Involving miR-22, Sp1, and c-Myc Modulates CD147 Expression in Breast Cancer Invasion and Metastasis
Authors: Kong Ling-Min , Liao Cheng-Gong , Zhang Yang , Xu Jing , Li Yu , Huang Wan , Zhang Yi , Bian Huijie , Chen Zhi-Nan
Published: March 2023

PDF file - 103K
Supplementary Figure 2 from Manganoporphyrins Increase Ascorbate-Induced Cytotoxicity by Enhancing H2O2 Generation
Authors: Rawal Malvika , Schroeder Samuel R. , Wagner Brett A. , Cushing Cameron M. , Welsh Jessemae L. , Button Anna M. , Du Juan , Sibenaller Zita A. , Buettner Garry R. , Cullen Joseph J.
Published: March 2023

PDF file - 43K, Supplementary Figure S2. A bolus of H2O2 decreases the plating efficiency of human pancreatic cancer cell lines.
Supplementary Table 2 from The Cancer Stem Cell Marker Aldehyde Dehydrogenase Is Required to Maintain a Drug-Tolerant Tumor Cell Subpopulation
Authors: Raha Debasish , Wilson Timothy R. , Peng Jing , Peterson David , Yue Peng , Evangelista Marie , Wilson Catherine , Merchant Mark , Settleman Jeff
Published: March 2023

XLSX file - 42KB, Statistical analysis of xenograft tumor data.
Supplementary Figure Legends, Table Legends from The Cancer Stem Cell Marker Aldehyde Dehydrogenase Is Required to Maintain a Drug-Tolerant Tumor Cell Subpopulation
Authors: Raha Debasish , Wilson Timothy R. , Peng Jing , Peterson David , Yue Peng , Evangelista Marie , Wilson Catherine , Merchant Mark , Settleman Jeff
Published: March 2023

PDF file - 76KB
Supplementary Table 3 from Cellular Disposal of miR23b by RAB27-Dependent Exosome Release Is Linked to Acquisition of Metastatic Properties
Authors: Ostenfeld Marie Stampe , Jeppesen Dennis K. , Laurberg Jens R. , Boysen Anders T. , Bramsen Jesper B. , Primdal-Bengtson Bjarke , Hendrix An , Lamy Philippe , Dagnaes-Hansen Frederik , Rasmussen Mads H. , Bui Khan H. , Fristrup Niels , Christensen Erik I. , Nordentoft Iver , Morth Jens P. , Jensen Jørgen B. , Pedersen Jakob S. , Beck Martin , Theodorescu Dan , Borre Michael , Howard Kenneth A. , Dyrskjøt Lars , Ørntoft Torben Falck
Published: March 2023

Lists of A)Quantitative mass spectrometry results of RNA-binding proteins in exosomes, B) Selected miRNAs for further analysis, and C) Downregulated mRNA transcripts (selected) upon RAB27B knockdown.
Supplemental Movie S1 from Novel Paracrine Modulation of Notch–DLL4 Signaling by Fibulin-3 Promotes Angiogenesis in High-Grade Gliomas
Authors: Nandhu Mohan S. , Hu Bin , Cole Susan E. , Erdreich-Epstein Anat , Rodriguez-Gil Diego J. , Viapiano Mariano S.
Published: March 2023

Animation of 3D confocal rendering related to Figure 3E.
Supplemental Figures S1-S5 from Novel Paracrine Modulation of Notch–DLL4 Signaling by Fibulin-3 Promotes Angiogenesis in High-Grade Gliomas
Authors: Nandhu Mohan S. , Hu Bin , Cole Susan E. , Erdreich-Epstein Anat , Rodriguez-Gil Diego J. , Viapiano Mariano S.
Published: March 2023

Fibulin-3 and DLL4 expression in human brain microvascular endothelial cells (S1); Expression of endothelial fibulin-3 is not induced by glioma cells (S2); Fibulin-3 increases glioma cell association with endothelial tubules (S3); Knockdown of fibulin-3 reduces expression of Notch-dependent genes in endothelial cells (S4); Fibulin-3 associates with secreted TIMP-3 (S5).
Supplementary Table 1 - 9 and Figures 1 - 14 from Quantitative Optical Imaging of Primary Tumor Organoid Metabolism Predicts Drug Response in Breast Cancer
Authors: Walsh Alex J. , Cook Rebecca S. , Sanders Melinda E. , Aurisicchio Luigi , Ciliberto Gennaro , Arteaga Carlos L. , Skala Melissa C.
Published: March 2023

Supplementary Figure 1: OMI endpoints of organoids derived from a trastuzumabresponsive xenograft tumor. Supplementary Figure 2: Population modeling identifies heterogeneous drug responses of BT474 cells. Supplementary Figure 3: OMI endpoints of organoids derived from a trastuzumab-resistant xenograft tumor. Supplementary Figure 4: Population modeling identifies heterogeneous drug responses of HR6 cells. Supplementary Figure 5: Population modeling identifies heterogeneous drug responses of organoids from patient sample #1 (ER+/HER2-). Supplementary Figure 6: OMI endpoints of organoids derived from a ER+ primary tumor. Supplementary Figure 7: Population modeling identifies heterogeneous drug responses of organoids from patient sample #2 (ER+/HER2-). Supplementary Figure 8: OMI endpoints of organoids derived from a second ER+ primary tumor. Supplementary Figure 9: Population modeling identifies heterogeneous drug responses of organoids from patient sample #3 (ER+/HER2-). Supplementary Figure 10: Population modeling identifies heterogeneous drug responses of organoids from patient sample #4 (ER+/HER2-). Supplementary Figure 11: OMI endpoints of organoids derived from a third ER+ primary tumor. Supplementary Figure 12: OMI endpoints of organoids derived from a fourth ER+ primary tumor. Supplementary Figure 13: OMI endpoints of organoids derived from a HER2+ primary tumor. Supplementary Figure 14: OMI endpoints of organoids derived from a TNBC primary tumor. Supplementary Table 1: NADH and FAD lifetime component values of BT474-xenograft derived organoids. Supplementary Table 2: NADH and FAD lifetime component values. Supplementary Table 3: Grade, proliferation rate, estrogen receptor expression, progesterone receptor expression, and HER2 receptor. Supplementary Table 4: NADH and FAD lifetime component values Supplementary Table 5: NADH and FAD lifetime component values of organoids. Supplementary Table 6: NADH and FAD lifetime component values. Supplementary Table 7: NADH and FAD lifetime component values of organoids derived from a fourth ER+ primary tumor. Supplementary Table 8: NADH and FAD lifetime component values of organoids derived from a HER2+ primary tumor. Supplementary Table 9: NADH and FAD lifetime component values of organoids derived from a TNBC primary tumor.
Supplementary Figure S4 from BET Protein Inhibitor JQ1 Attenuates Myc-Amplified MCC Tumor Growth In Vivo
Authors: Shao Qiang , Kannan Aarthi , Lin Zhenyu , Stack Brendan C. , Suen James Y. , Gao Ling
Published: March 2023

Supplementary Figure S4. JQ1 suppresses MCC-2 cell proliferation; successful knockdown of p21, p27 and p57 expression in MCC cells; JQ1 increases Notch1 and NFï�«B gene expressions in MCC-3 and MCC-5 cells.
Supplemental Figures S1-S6 from Hedgehog Signaling Drives Radioresistance and Stroma-Driven Tumor Repopulation in Head and Neck Squamous Cancers
Authors: Gan Gregory N. , Eagles Justin , Keysar Stephen B. , Wang Guoliang , Glogowska Magdalena J. , Altunbas Cem , Anderson Ryan T. , Le Phuong N. , Morton J. Jason , Frederick Barbara , Raben David , Wang Xiao-Jing , Jimeno Antonio
Published: March 2023

Supplemental Figures S1-S6. Comparison of HN11 and TU167 by RNA-Seq Expression (S1); Suppression of Radiation-induced GLI1 using shRNA Model (S2); Cyst Formation Following Radiation Treatment in Orthotopic TU167-implanted Tumors (S3); Radiation-induced Gli1 Expression and the Effect of Rapamycin Inhibition in HN11 Cells (S4); Effect of siRNA inhibition on Head Neck Cancer Cells and Gli1 Nuclear Translocation (S5); Schema and Histology Detailing Radiation-induced Tumor Repopulation (S6).
Supplementary Figure 2 from Cancer-Associated Adipose Tissue Promotes Breast Cancer Progression by Paracrine Oncostatin M and Jak/STAT3 Signaling
Authors: Lapeire Lore , Hendrix An , Lambein Kathleen , Van Bockstal Mieke , Braems Geert , Van Den Broecke Rudy , Limame Ridha , Mestdagh Pieter , Vandesompele Jo , Vanhove Christian , Maynard Dawn , Lehuédé Camille , Muller Catherine , Valet Philippe , Gespach Christian P. , Bracke Marc , Cocquyt Veronique , Denys Hannelore , De Wever Olivier
Published: March 2023

Upper panels: Western blot analysis of E-cadherin, beta-catenin, vimentin, fibronectin, pancytokeratin and estrogen receptor alpha (ERα). Left panel: MCF-7 cells treated for 48h with control medium or CMCAAT. Right panel: MCF-7 cells stably transfected with GFP or OSM cDNA, or treated for 48h with rhOSM (1ng/ml). Tubulin serves as an internal control. Lower left panel: Confocal images of the F-actin cytoskeleton (red), nuclear staining DAPI (blue) and merged signals in MCF-7 cells treated for 48h with control medium or CMCAAT (scale bar is 20 μm) and confocal images of E-cadherin (green), beta-catenin (red) and merge signals with DAPI in MCF-7 cells treated for 48h with control medium or CMCAAT (scale bar is 10 μm). Lower right panel: Immunohistochemical staining of MCF-7-GFP and MCF-7-OSM tumor xenografts for E-cadherin, vimentin, pancytokeratin and ERα (scale bar is 25 µm).
Data Supplement from The SIRT1/HIF2α Axis Drives Reductive Glutamine Metabolism under Chronic Acidosis and Alters Tumor Response to Therapy
Authors: Corbet Cyril , Draoui Nihed , Polet Florence , Pinto Adan , Drozak Xavier , Riant Olivier , Feron Olivier
Published: March 2023

Supplementary Figure S2. Chronic acidosis increases amino-acid uptake.
Data Supplement from The SIRT1/HIF2α Axis Drives Reductive Glutamine Metabolism under Chronic Acidosis and Alters Tumor Response to Therapy
Authors: Corbet Cyril , Draoui Nihed , Polet Florence , Pinto Adan , Drozak Xavier , Riant Olivier , Feron Olivier
Published: March 2023

Description of additional methods and procedures used in the study.
Supplementary Figure S7 from β-Catenin Contributes to Lung Tumor Development Induced by EGFR Mutations
Authors: Nakayama Sohei , Sng Natasha , Carretero Julian , Welner Robert , Hayashi Yuichiro , Yamamoto Mihoko , Tan Alistair J. , Yamaguchi Norihiro , Yasuda Hiroyuki , Li Danan , Soejima Kenzo , Soo Ross A. , Costa Daniel B. , Wong Kwok-Kin , Kobayashi Susumu S.
Published: March 2023

Incomplete deletion of β-catenin gene leads to tumor formation in EGFRTL/CCSP-rtTA/Cre/Ctnnb1F/F mice.
Data Supplement from RB Family Tumor Suppressor Activity May Not Relate to Active Silencing of E2F Target Genes
Authors: Vormer Tinke L. , Wojciechowicz Kamila , Dekker Marleen , de Vries Sandra , van der Wal Anja , Delzenne-Goette Elly , Naik Sjalin H. , Song Ji-Ying , Dannenberg Jan-Hermen , Hansen Jacob B. , te Riele Hein
Published: March 2023

Supplementary Table S2. Neoplastic lesions detected in Rb/p130 and Rb/p107 mutant mice.
Supplementary Table 2 from Activated d16HER2 Homodimers and SRC Kinase Mediate Optimal Efficacy for Trastuzumab
Authors: Castagnoli Lorenzo , Iezzi Manuela , Ghedini Gaia C. , Ciravolo Valentina , Marzano Giulia , Lamolinara Alessia , Zappasodi Roberta , Gasparini Patrizia , Campiglio Manuela , Amici Augusto , Chiodoni Claudia , Palladini Arianna , Lollini Pier Luigi , Triulzi Tiziana , Menard Sylvie , Nanni Patrizia , Tagliabue Elda , Pupa Serenella M.
Published: March 2023

Frequency of clinico-pathological characteristics in HER2-positive BC patients according to pSrc classification.
Data Supplement from RB Family Tumor Suppressor Activity May Not Relate to Active Silencing of E2F Target Genes
Authors: Vormer Tinke L. , Wojciechowicz Kamila , Dekker Marleen , de Vries Sandra , van der Wal Anja , Delzenne-Goette Elly , Naik Sjalin H. , Song Ji-Ying , Dannenberg Jan-Hermen , Hansen Jacob B. , te Riele Hein
Published: March 2023

Supplementary Figure S3. Cell cycle arrest in RbN750F/N750F and Rb-/- MEFs shifts towards G2 in response to high doses of γ-irradiation.
Data Supplement from RB Family Tumor Suppressor Activity May Not Relate to Active Silencing of E2F Target Genes
Authors: Vormer Tinke L. , Wojciechowicz Kamila , Dekker Marleen , de Vries Sandra , van der Wal Anja , Delzenne-Goette Elly , Naik Sjalin H. , Song Ji-Ying , Dannenberg Jan-Hermen , Hansen Jacob B. , te Riele Hein
Published: March 2023

Supplementary Table and Figure Legend. Legends to Supplementary Tables S1-S3 and Supplementary Figures S1-S4.
Supplementary Figure 5 from Loss of Cdk2 and Cyclin A2 Impairs Cell Proliferation and Tumorigenesis
Authors: Gopinathan Lakshmi , Tan Shawn Lu Wen , Padmakumar V. C. , Coppola Vincenzo , Tessarollo Lino , Kaldis Philipp
Published: March 2023

PDF file - 213KB, FACS analysis of primary MEFs.
Supplementary Methods, Figure from EWS–WT1 Oncoprotein Activates Neuronal Reprogramming Factor ASCL1 and Promotes Neural Differentiation
Authors: Kang Hong-Jun , Park Jun Hong , Chen WeiPing , Kang Soo Im , Moroz Krzysztof , Ladanyi Marc , Lee Sean Bong
Published: March 2023

PDF file - 218K
Supplmentary Figures 1-9 from BRCA1 Suppresses Epithelial-to-Mesenchymal Transition and Stem Cell Dedifferentiation during Mammary and Tumor Development
Authors: Bai Feng , Chan Ho Lam , Scott Alexandria , Smith Matthew D. , Fan Cheng , Herschkowitz Jason I. , Perou Charles M. , Livingstone Alan S. , Robbins David J. , Capobianco Anthony J. , Pei Xin-Hai
Published: March 2023

Supplementary Figures 1-9 - Germline mutation of Brca1 transforms p18-deficient luminal tumors into basal-like tumors with induction of EMT (Suppl. Fig. 1); Germline mutation of Brca1 activates EMT-TFs in mammary and tumor development (Suppl. Fig. 2); Specific deletion of Brca1 in mammary epithelia impairs luminal differentiation (Suppl. Fig. 3); Haploid loss of Brca1 in mammary epithelium inhibits the expression of luminal genes but stimulates the expression of basal genes and EMT-TFs in p18 deficient LSCs (Suppl. Fig. 4); Ck5 and Ck8 double positive epithelial cells are frequently detected in p18-/-;Brca1f/-;MC mammary glands (Suppl. Fig. 5); Characterization of human breast cancer cell lines (Suppl. Fig. 6); BRCA1 inhibits the expression of TWIST and FOXC2 in 293T cells (Suppl. Fig. 7); Knockdown of BRCA1 in T47D cells activates EMT (Suppl. Fig. 8); BRCA1 and TWIST mRNA levels are inversely correlated in human claudin-low type breast cancers (Suppl. Fig. 9).
Supplementary Figure 6 from EWS–WT1 Oncoprotein Activates Neuronal Reprogramming Factor ASCL1 and Promotes Neural Differentiation
Authors: Kang Hong-Jun , Park Jun Hong , Chen WeiPing , Kang Soo Im , Moroz Krzysztof , Ladanyi Marc , Lee Sean Bong
Published: March 2023

PDF file - 19K, Expression of E-KTS in the mouse blocks proliferation of intestinal epithelial cells in crypts of small intestine.
Supplementary Figure 3 from EWS–WT1 Oncoprotein Activates Neuronal Reprogramming Factor ASCL1 and Promotes Neural Differentiation
Authors: Kang Hong-Jun , Park Jun Hong , Chen WeiPing , Kang Soo Im , Moroz Krzysztof , Ladanyi Marc , Lee Sean Bong
Published: March 2023

PDF file - 877K, Neural pathway genes are enriched in primary DSRCT.
Supplementary Methods and References from Network Modeling of TGFβ Signaling in Hepatocellular Carcinoma Epithelial-to-Mesenchymal Transition Reveals Joint Sonic Hedgehog and Wnt Pathway Activation
Authors: Steinway Steven Nathaniel , Zañudo Jorge G.T. , Ding Wei , Rountree Carl Bart , Feith David J. , Loughran Thomas P. , Albert Reka
Published: March 2023

Description of additional methods and procedures used in the study. Also includes Supplementary References.
Supplementary Figures S1-S5 from Network Modeling of TGFβ Signaling in Hepatocellular Carcinoma Epithelial-to-Mesenchymal Transition Reveals Joint Sonic Hedgehog and Wnt Pathway Activation
Authors: Steinway Steven Nathaniel , Zañudo Jorge G.T. , Ding Wei , Rountree Carl Bart , Feith David J. , Loughran Thomas P. , Albert Reka
Published: March 2023

TGFβR inhibition suppresses mesenchymal features in human HCC cell lines (S1); AXIN2 and GLI are induced by Wnt and SHH signals in the epithelial-to-mesenchymal transition network model (S2); All stable motifs (feedback loops) stabilizing the TGFβ-driven EMT phenotype (S3); The ratio between the timescale of the slow and fast processes does not matter as long as it is significantly larger than one (S4); Exploration of alternative rules to describe nuclear localization of β-catenin (S5).
Supplementary Figures 1 - 3 from Autologous T-cell Therapy for Cytomegalovirus as a Consolidative Treatment for Recurrent Glioblastoma
Authors: Schuessler Andrea , Smith Corey , Beagley Leone , Boyle Glen M. , Rehan Sweera , Matthews Katherine , Jones Linda , Crough Tania , Dasari Vijayendra , Klein Kerenaftali , Smalley Amy , Alexander Hamish , Walker David G. , Khanna Rajiv
Published: March 2023

PDF file - 216KB, Antigen-specific T-cell responses in the peripheral blood following CMV-specific T-cell infusion (S1). Molecular profiling of T-cell therapy (S2). Longitudinal comparative phenotypic analysis of peripheral blood circulating and tumour infiltrating CD8+ T-cells from a GBM patient (S3).
Data Supplement from Enhancing Reproducibility in Cancer Drug Screening: How Do We Move Forward?
Authors: Hatzis Christos , Bedard Philippe L. , Birkbak Nicolai J. , Beck Andrew H. , Aerts Hugo J.W.L. , Stern David F. , Shi Leming , Clarke Robert , Quackenbush John , Haibe-Kains Benjamin
Published: March 2023

Comparison of experimental protocols used in CGP and CCLE. Description of the major potential source of variability in phenotypic measurements between CGP and CCLE phenotype, due to differences in detection assay, quality assurance of screening plates, controls, and measures of drug potency (IC50).
Supplemental Figure 5 from Force Engages Vinculin and Promotes Tumor Progression by Enhancing PI3K Activation of Phosphatidylinositol (3,4,5)-Triphosphate
Authors: Rubashkin Matthew G. , Cassereau Luke , Bainer Russell , DuFort Christopher C. , Yui Yoshihiro , Ou Guanqing , Paszek Matthew J. , Davidson Michael W. , Chen Yunn-Yi , Weaver Valerie M.
Published: March 2023

Vinculin is localized to cell-ECM borders in invasive breast cancer and adhesome proteins are upregulated across human cancers.
Supplemental Figure 1 from Force Engages Vinculin and Promotes Tumor Progression by Enhancing PI3K Activation of Phosphatidylinositol (3,4,5)-Triphosphate
Authors: Rubashkin Matthew G. , Cassereau Luke , Bainer Russell , DuFort Christopher C. , Yui Yoshihiro , Ou Guanqing , Paszek Matthew J. , Davidson Michael W. , Chen Yunn-Yi , Weaver Valerie M.
Published: March 2023

ECM cues, malignant transformation, and integrin signaling, promote cell spreading and invasion.
Data Supplement from Combined SFK/mTOR Inhibition Prevents Rapamycin-Induced Feedback Activation of AKT and Elicits Efficient Tumor Regression
Authors: Yori Jennifer L. , Lozada Kristen L. , Seachrist Darcie D. , Mosley Jonathan D. , Abdul-Karim Fadi W. , Booth Christine N. , Flask Chris A. , Keri Ruth A.
Published: March 2023

Supplementary Figure S7. Immunohistochemical analysis of target inhibition by rapamycin (p-S6) and dasatinib (p-Src) in MMTV-PyMT tumor sections.
Supplementary Table S1 from TRAP1 Is Involved in BRAF Regulation and Downstream Attenuation of ERK Phosphorylation and Cell-Cycle Progression: A Novel Target for BRAF-Mutated Colorectal Tumors
Authors: Condelli Valentina , Piscazzi Annamaria , Sisinni Lorenza , Matassa Danilo Swann , Maddalena Francesca , Lettini Giacomo , Simeon Vittorio , Palladino Giuseppe , Amoroso Maria Rosaria , Trino Stefania , Esposito Franca , Landriscina Matteo
Published: March 2023

Genes differently expressed in HCT116 TRAP1-silenced cells. Genes were selected with differential score cutoff set at {plus minus}30 (p < 0.001).
Supplementary File 4 from Nuclear Factor of Activated T-cell Activity Is Associated with Metastatic Capacity in Colon Cancer
Authors: Tripathi Manish K. , Deane Natasha G. , Zhu Jing , An Hanbing , Mima Shinji , Wang Xiaojing , Padmanabhan Sekhar , Shi Zhiao , Prodduturi Naresh , Ciombor Kristen K. , Chen Xi , Washington M. Kay , Zhang Bing , Beauchamp R. Daniel
Published: March 2023

Supplementary File 4. Promoter regions from HUMAN NFAT family target genes shown in Figure 1E, showing location of NFAT consensus binding sequences
Supp Table S5 from In Vivo Disruption of an Rb–E2F–Ezh2 Signaling Loop Causes Bladder Cancer
Authors: Santos Mirentxu , Martínez-Fernández Mónica , Dueñas Marta , García-Escudero Ramón , Alfaya Begoña , Villacampa Felipe , Saiz-Ladera Cristina , Costa Clotilde , Oteo Marta , Duarte José , Martínez Victor , Gómez-Rodriguez Ma José , Martín Ma Luisa , Fernández Manoli , Viatour Patrick , Morcillo Miguel A. , Sage Julien , Castellano Daniel , Rodriguez-Peralto Jose L. , de la Rosa Federico , Paramio Jesús M
Published: March 2023

Supp Table S5. Transcription factor analyzed by Chip Enrichment analysis of the downregulated genes in mouse bladder tumors.
Supp Table S2 from In Vivo Disruption of an Rb–E2F–Ezh2 Signaling Loop Causes Bladder Cancer
Authors: Santos Mirentxu , Martínez-Fernández Mónica , Dueñas Marta , García-Escudero Ramón , Alfaya Begoña , Villacampa Felipe , Saiz-Ladera Cristina , Costa Clotilde , Oteo Marta , Duarte José , Martínez Victor , Gómez-Rodriguez Ma José , Martín Ma Luisa , Fernández Manoli , Viatour Patrick , Morcillo Miguel A. , Sage Julien , Castellano Daniel , Rodriguez-Peralto Jose L. , de la Rosa Federico , Paramio Jesús M
Published: March 2023

Supp Table S2. Dataset containing the list of upregulated and downregulated genes in mouse bladder tumors.
Supp Table S15 from In Vivo Disruption of an Rb–E2F–Ezh2 Signaling Loop Causes Bladder Cancer
Authors: Santos Mirentxu , Martínez-Fernández Mónica , Dueñas Marta , García-Escudero Ramón , Alfaya Begoña , Villacampa Felipe , Saiz-Ladera Cristina , Costa Clotilde , Oteo Marta , Duarte José , Martínez Victor , Gómez-Rodriguez Ma José , Martín Ma Luisa , Fernández Manoli , Viatour Patrick , Morcillo Miguel A. , Sage Julien , Castellano Daniel , Rodriguez-Peralto Jose L. , de la Rosa Federico , Paramio Jesús M
Published: March 2023

Supp Table S15. Transcription factor analyzed by Chip Enrichment analysis of the downregulated genes in human recurrent bladder tumors.
Data Supplement from Armed Oncolytic Virus Enhances Immune Functions of Chimeric Antigen Receptor–Modified T Cells in Solid Tumors
Authors: Nishio Nobuhiro , Diaconu Iulia , Liu Hao , Cerullo Vincenzo , Caruana Ignazio , Hoyos Valentina , Bouchier-Hayes Lisa , Savoldo Barbara , Dotti Gianpietro
Published: March 2023

Supplementary Movie 1A. Control T cell
Supplemental Movie 3 from AXL Inhibition Sensitizes Mesenchymal Cancer Cells to Antimitotic Drugs
Authors: Wilson Catherine , Ye Xiaofen , Pham Thinh , Lin Eva , Chan Sara , McNamara Erin , Neve Richard M. , Belmont Lisa , Koeppen Hartmut , Yauch Robert L. , Ashkenazi Avi , Settleman Jeff
Published: March 2023

Timelapse movie of HeLa cells treated with docetaxel (3nM).
Supplementary Table S1 from Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer
Authors: Mouradov Dmitri , Sloggett Clare , Jorissen Robert N. , Love Christopher G. , Li Shan , Burgess Antony W. , Arango Diego , Strausberg Robert L. , Buchanan Daniel , Wormald Samuel , O'Connor Liam , Wilding Jennifer L. , Bicknell David , Tomlinson Ian P.M. , Bodmer Walter F. , Mariadason John M. , Sieber Oliver M.
Published: March 2023

CRC cell line details and major molecular hallmarks.
Supplementary Table 3 from Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer
Authors: Mouradov Dmitri , Sloggett Clare , Jorissen Robert N. , Love Christopher G. , Li Shan , Burgess Antony W. , Arango Diego , Strausberg Robert L. , Buchanan Daniel , Wormald Samuel , O'Connor Liam , Wilding Jennifer L. , Bicknell David , Tomlinson Ian P.M. , Bodmer Walter F. , Mariadason John M. , Sieber Oliver M.
Published: March 2023

XLSX file - 45KB, Sanger sequencing validation for mutations detected by exome-capture sequencing for 12 genes in 43 CRC cell lines. Genes comprised APC, CTNNB1, KRAS, BRAF, NRAS, PIK3CA, PTEN, SMAD2, SMAD3, SMAD4, FBXW7 and TP53. Cell lines included C32, C70, C80, C84, C99, C106, CACO2, COLO201, COLO205, COLO320-DM, COLO678, DLD1, HCA7, HCC2998, HCT8, HCT15, HCT116, HRA19, HT29, HT55, LIM1215, LIM1899, LIM2099, LIM2405, LIM2551, LOVO, LS174T, LS180, LS411, LS513, RKO, RW2982, RW7213, SW48, SW403, SW480, SW620, SW837, SW948, SW1116, SW1222, T84 and VACO4S.
Supplementary Figures S1-S2 from PAK1 Tyrosine Phosphorylation Is Required to Induce Epithelial–Mesenchymal Transition and Radioresistance in Lung Cancer Cells
Authors: Kim EunGi , Youn HyeSook , Kwon TaeWoo , Son Beomseok , Kang JiHoon , Yang Hee Jung , Seong Ki Moon , Kim Wanyeon , Youn BuHyun
Published: March 2023

The activity of an anti-pSer/Thr antibody and overexpression of each PAK1 construct after transient transfection were verified (S1); JAK2 phosphorylates PAK1 in irradiated NSCLC cells (S2).
Supplementary Figure S1 from Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer
Authors: Mouradov Dmitri , Sloggett Clare , Jorissen Robert N. , Love Christopher G. , Li Shan , Burgess Antony W. , Arango Diego , Strausberg Robert L. , Buchanan Daniel , Wormald Samuel , O'Connor Liam , Wilding Jennifer L. , Bicknell David , Tomlinson Ian P.M. , Bodmer Walter F. , Mariadason John M. , Sieber Oliver M.
Published: March 2023

Correlation between RNA-Seq and gene expression microarray data (Affymetrix U133 Plus2.0 Arrays) for six CRC cell lines analyzed in independent experiments. Genes with detectable expression on both platforms were considered, defined as RNA-Seq RPKM value >1 and microarray intensity > log2(100). r-values, Spearman's rank correlation coefficient.
Supplementary Figure 6 from GPER Mediates Activation of HIF1α/VEGF Signaling by Estrogens
Authors: De Francesco Ernestina Marianna , Pellegrino Michele , Santolla Maria Francesca , Lappano Rosamaria , Ricchio Emilia , Abonante Sergio , Maggiolini Marcello
Published: March 2023

PDF file - 80KB, Supplementary Figure S6: Transduction signaling activated by GPER ligands.
Data Supplement from Epigenetic Targeting of Ovarian Cancer Stem Cells
Authors: Wang Yinu , Cardenas Horacio , Fang Fang , Condello Salvatore , Taverna Pietro , Segar Matthew , Liu Yunlong , Nephew Kenneth P. , Matei Daniela
Published: March 2023

Supplemental Section including supplemental methods and materials, supplementary tables and supplementary figure legends. Supplemental Table S1. Primer sequences of selected genes. Supplemental Table S2: %ALDH(+) cells in high serous ovarian cancer. Supplemental Table S3: Growth of xenograft tumors derived from ALDH(+) or ALDH(-) OC cells. Supplemental Table S4: Promoter CpG island containing genes hypomethylated by SGI-110.
Supplemental Figure 3 from Adenosine A2A Receptors Intrinsically Regulate CD8+ T Cells in the Tumor Microenvironment
Authors: Cekic Caglar , Linden Joel
Published: March 2023

Supplementary Figure 3. Effects of T cell-selective A2AR deletion on thymocytes in B16F10 bearing mice.
Supplemental data from Tumor-Derived Osteopontin Suppresses Antitumor Immunity by Promoting Extramedullary Myelopoiesis
Authors: Kim Eun-Kyung , Jeon Insu , Seo Hyungseok , Park Young-Jun , Song Boyeong , Lee Kyoo-A , Jang Yongwoo , Chung Yeonseok , Kang Chang-Yuil
Published: March 2023

Supplemental data. Supplementary method, Supplementary figure legends and Supplementary figures 1-9. Supplementary figure 1. Gating strategies for the flow cytometric analysis. Supplementary figure 2. Changes of MDSCs, lymphoid cells and lymphoid progenitor cells in the CT26 TBM. Supplementary figure 3. Accumulated MDSCs in MC38 TBM. Supplementary figure 4. Increased osteopontin in MC38 TBM. Supplementary figure 5. In vivo proliferation and apoptosis of tumors. Supplementary figure 6. Changes of sub-populations of LK cells. Supplementary figure 7. Induction of extramedullary myelopoiesis by osteopontin from malignant tumor cells in the tumor microenvironment. Supplementary figure 8. The role of osteopontin in LK cell migration and MDSC survival. Supplementary figure 9. Osteopontin-induced LK cell proliferation was mediated by the CD44-ERK/MAPK signaling pathway.
Supplementary Figure S3 from GPx2 Suppression of H2O2 Stress Links the Formation of Differentiated Tumor Mass to Metastatic Capacity in Colorectal Cancer
Authors: Emmink Benjamin L. , Laoukili Jamila , Kipp Anna P. , Koster Jan , Govaert Klaas M. , Fatrai Szabolcs , Verheem Andre , Steller Ernst J.A. , Brigelius-Flohé Regina , Jimenez Connie R. , Borel Rinkes Inne H.M. , Kranenburg Onno
Published: March 2023

Supplementary Figure S3. Loss of GPx2 reduces tumor growth.
Supplementary Figure 2. Competition assay cell lines and control cohorts from Ceramide Kinase Promotes Tumor Cell Survival and Mammary Tumor Recurrence
Authors: Payne Ania W. , Pant Dhruv K. , Pan Tien-Chi , Chodosh Lewis A.
Published: March 2023

(A) qRT-PCR analysis of Cerk mRNA expression in Cerk knockdown tumor cell lines. (B) Percentage of eGFP-positive and mCherry-positive cells at timepoints in Figure 3A in control cohort and (C) in a second shRNA cohort.
Supplementary Figure 4 from Targeting the MYC and PI3K Pathways Eliminates Leukemia-Initiating Cells in T-cell Acute Lymphoblastic Leukemia
Authors: Schubbert Suzanne , Cardenas Anjelica , Chen Harrison , Garcia Consuelo , Guo Wei , Bradner James , Wu Hong
Published: March 2023

Sensitivity of primary human pediatric T-ALL cells to rapamycin and JQ1 in vitro.
Supplementary Tables S1-S4 from Combined Genome and Transcriptome Analysis of Single Disseminated Cancer Cells from Bone Marrow of Prostate Cancer Patients Reveals Unexpected Transcriptomes
Authors: Gužvić Miodrag , Braun Bernhard , Ganzer Roman , Burger Maximilian , Nerlich Michael , Winkler Sebastian , Werner-Klein Melanie , Czyż Zbigniew T. , Polzer Bernhard , Klein Christoph A.
Published: March 2023

Supplementary Tables S1-S4. Supplementary Table S1 - Sequences of primers used in this study. Supplementary Table S2 - Detection rate of EpCAM+ cells and the number of isolated and analyzes EpCAM+ single cells. Supplementary Table S3 - Numbers and frequencies of samples expressing analyzed transcripts. Supplementary Table S4 - Distribution of cells expressing or co-expressing EPCAM and KRT transcripts.
Supplementary Figure 4 from mTOR Signaling Feedback Modulates Mammary Epithelial Differentiation and Restrains Invasion Downstream of PTEN Loss
Authors: Ghosh Susmita , Varela Lidenys , Sood Akshay , Park Ben Ho , Lotan Tamara L.
Published: March 2023

PDF - 3219 KB, (A) DIC imaging of MCF10A clones cultured for 24 hours on in pure Matrigel. Scale bars = 100 and 20 microm. (B) Quantification of invasive protrusion formation after 24 hours of culture on Matrigel. (represents mean and SEM for 3 independent replicates).
Supplement Information from Vitamin D Suppresses Leptin Stimulation of Cancer Growth through microRNA
Authors: Kasiappan Ravi , Sun Yuefeng , Lungchukiet Panida , Quarni Waise , Zhang Xiaohong , Bai Wenlong
Published: March 2023

Supplement Information. Supplement Methods and Legends
Supplemental Fig. 7 from Pancreatic Cancer–Specific Cell Death Induced In Vivo by Cytoplasmic-Delivered Polyinosine–Polycytidylic Acid
Authors: Bhoopathi Praveen , Quinn Bridget A. , Gui Qin , Shen Xue-Ning , Grossman Steven R. , Das Swadesh K. , Sarkar Devanand , Fisher Paul B. , Emdad Luni
Published: March 2023

Supplemental Fig. 7. [pIC]PEI treatment inhibits mTOR and PKC-É› activation in pancreatic cancer cells