bluuebunny/crossref_metadata_2025 huggingface dataset:
Importancia de la estructura financiera para el fortalecimiento de las pymes en la Provincia de Manabí
Authors: Tualombo-Tituaña José , Figueroa-Soledispa Martha , Moreno-Ponce María
Published: September 2022

La presente investigación se desarrolla con el objetivo de estudiar la importancia de la estructura financiera de las pequeñas y medianas empresas de la provincia de Manabí. Por lo cual, se lleva a cabo un artículo científico enmarcado una metodología de enfoque cuantitativo de tipo descriptivo y carácter no experimental, aplicando como instrumentos de recolección de información la revisión documental que resalten la importancia de la estructura financiera en el fortalecimiento de las pymes y la encuesta, para conocer opiniones y experiencias de los propietarios de las pymes de la provincia de Manabí. Entre los principales resultados se destaca que, a través de la estructura financiera se conocen los fondos de financiamiento de la empresa, por lo que es importante estudiar esta herramienta en virtud de tomar decisiones económicas seguras, que prevengan el fracaso de la organización y conduzcan a la rentabilidad y sostenibilidad en el tiempo de la misma. En esta línea, los propietarios de las pymes de la provincia de Manabí consideran importante el estudio de la estructura financiera como herramienta para la toma de decisiones acertadas, por lo que llevan un registro financiero en virtud de controlar las finanzas permitiendo esto fortalecer las empresas, a través de la ejecución eficiente de los recursos con los que disponen las organizaciones, ya que el control financiero es un instrumento de diagnóstico que permite controlar, evaluar, y analizar los fondos con los que cuentan estas pymes que simbolizan un sector sumamente importante en el desarrollo económico de la comunidad.
Guía de importación para la industria del calzado de Huaquillas mediante ZEDES, 2022
Authors: Rueda-Jumbo Josselyn , Torres-Torres Milady , Guzmán-Arias Rocío de Lourdes
Published: September 2022

En Ecuador el cambio de su matriz productiva ha sido un reto que ha adquirido una mejora notable, debido a que ha aumentado la productividad e impulsado la innovación en los últimos años. Se establece que entre uno de los factores desencadenantes es la posibilidad de obtener capacidad tecnológica a través de los bienes de capital, lo que permite ganar oportunidad en la industrialización para diversos sectores productivos con el fin de convertirse en una nación con una industria próspera. El presente artículo tiene por objetivo impulsar la importación de maquinaria a través de ZEDEs para el sector calzado Huaquillas-El Oro, 2022 mediante la presentación de una guía de importación. De acuerdo al tipo de investigación, es explicativo-transformador, con una investigación de campo. El estudio tiene un paradigma cuantitativo, donde se utilizaron métodos empíricos y estadísticos. La muestra seleccionada fue de 38 fabricantes del cantón Huaquillas. Se utilizó como instrumento el cuestionario de preguntas con opción múltiple de respuesta para la encuesta; para la entrevista, se utilizó un banco de preguntas abiertas. Como resultado de las dimensiones estudiadas: factor interno, externo, compra e importación en el contexto real, las fábricas no cuentan con la maquinaria suficiente y tecnificada para el desarrollo de sus actividades, así como también, carecen de cultura importadora lo que les ha impedido, la industrialización en los diversos sectores productivos.
La organización y planificación del trabajo eficiente a través de la administración de proyectos
Authors: Larrochelli Muñiz Manuel Antonio , Salazar Garcés Génesis Kristel , Toro Espinoza Marcos Fernando , Carrillo Pérez Fernando Xavier
Published: September 2022

El propósito de este artículo consiste en analizar la organización y planificación del trabajo eficiente a través de la administración de proyectos a través de una revisión bibliográfica. Se abordan los conceptos sobre trabajo, organización, planificación, administración de proyectos, las relaciones entre esos conceptos y la incidencia en el contexto empresarial y organizacional. De esto se concluye que el trabajo es una actividad ejecutada por el ser humano desde que dejó de ser nómada, que genera bienes y servicios, razón por la cual debe generar también riqueza y confort a quien lo realiza. No es un proceso aislado pues necesita de otros procesos: Organización, planificación, ejecución y control.
Ruido ambiental generado en calles adyacentes a mercados de la ciudad de Juliaca y sus efectos en la salud humana 2021
Authors: Condori-Cutipa Pablo , Apaza-Pérez Oscar
Published: September 2022

Se hizo la evaluación del ruido ambiental en las entradas y salidas de las calles cercanas a cuatro mercados de la ciudad de Juliaca y el impacto de este en la salud poblacional que circulan por estos sectores, el método que se propuso fue cuantitativo descriptivo con diseño no experimental. Se consideró cuatro puntos de monitoreo en cada mercado, se hizo la medición en horarios (8:00 - 18:00), hallando un valor LAeq de 73.35 dB en el mercado Manco Cápac siendo este el valor más alto encontrado en los cuatro mercados evaluados, concluyendo que existe un gran porcentaje de los puntos de monitoreo cuyos valores están por encima de los 70dB permitidos en áreas comerciales según el ECA para ruido nacional; de las encuestas realizadas un 27.34% de la población manifiestan que le generan dolores de cabeza, a un 17.71 % les provoca estrés y ansiedad, hay un 17.19% que no se pueden concentrar, existe también un 10.68% que presenta problemas auditivos e irritabilidad, el 4.17% problemas de memoria y solo un 1.04% manifestaron no tener problema alguno.
Estudio de las sanciones indirectas, derivadas de la inhabilitación por inconsistencias en la declaración del “valor agregado ecuatoriano” (VAE) en la contratación pública
Authors: Ordóñez-Carpio Fernando , Vega-Crespo Elizabeth
Published: September 2022

En el presente artículo, se estudia los actos administrativos que dan como resultado la suspensión en el “Registro Único de Proveedores RUP”, impuesta por el “Servicio Nacional de Contratación Pública” SERCOP, a proveedores del Estado,  que han  proporcionado información o realizado una declaración errónea respecto de su calidad de productor nacional, dentro de un procedimiento de contratación pública; pero que, no obstante la aplicación de la referida sanción, hallándose  bloqueados en el “Portal de Compras Públicas”, se ven impedidos  de cumplir otras obligaciones previamente contraídas, como la suscripción de contratos adjudicados con anterioridad en otros procesos; y, por consecuencia de un evento forzoso ajeno a su voluntad, son objeto de una sanción significativamente superior.

Se delinea los mecanismos a utilizar para conseguir su rehabilitación en el Sistema Nacional de Contratación Pública, así como las eventuales acciones judiciales y administrativas para conseguir el resarcimiento de los daños injustamente ocasionados.
САМОСТІЙНА РОБОТА З ВИКОРИСТАННЯМ ХМАРО ОРІЄНТОВАНИХ ТЕХНОЛОГІЙ ЯК ЗАСІБ РОЗВИТКУ ЦИФРОВОЇ КОМПЕТЕНТНОСТІ МАГІСТРІВ ФІЗИКИ
Authors: Головко Микола Васильович , Крижановський Сергій Юрійович , Мацюк Віктор Михайлович
Published: September 2022

В умовах глобальних викликів і непередбачуваних обставин, що постають перед освітньою системою, широкого використання набуває дистанційне навчання та зростає вага й роль активної самостійної навчально-пізнавальної діяльності студентів як важливої умови формування професійної компетентності. У статті досліджується проблема вдосконалення самостійної роботи магістрів фізики, організованої засобами хмаро орієнтованих технологій, як чинник розвитку самоосвітньої і цифрової компетентностей здобувачів вищої освіти.
На основі огляду широкого кола джерел, у яких висвітлено загальні підходи щодо проєктування та функціонування освітнього середовища в умовах інформатизації, з’ясовано, що одним з найбільш ефективних на сьогодні інструментів організації самостійної роботи студентів є засоби хмаро орієнтованих технологій, що базуються на хмарних обчисленнях.
Визначено основні напрями використання хмаро орієнтованих технологій самостійної роботи магістрів фізики: управління навчально-пізнавальною діяльністю, забезпечення комунікацій між суб’єктами та організації спільної роботи, планування освітнього процесу, безперервний моніторинг результатів навчання здобувачів вищої освіти, створення, редагування, зберігання та презентування навчальних матеріалів, використання хмарних цифрових лабораторій та сервісів оброблення експериментальних результатів.
Описано приклади використання таких хмарних засобів підтримки під час самостійної роботи студентів, як додатки хмаро орієнтованого пакету програм Microsoft Office 365, хмарний сервіс для створення діаграм різних типів Gliffy, віртуальна онлайн-лабораторія PhET Interactive Simulations, системи для моделювання Wolfram Mathematica Online, Multisim Live.
Експериментально досліджено рівень сформованості умінь магістрів фізики використовувати засоби хмаро орієнтованих технологій для розв’язання освітньо-наукових задач, створення дидактичного забезпечення освітнього процесу з фізики. Запропоновано шляхи їх удосконалення під час самостійної роботи як засобу розвитку цифрової компетентності магістрів фізики.
AKCİĞER TÜMÖRLERİNE YÖNELİK PAKLİTAKSEL YÜKLÜ POLİKAPROLAKTON NANOPARTİKÜLLERİ; FORMÜLASYON, KAPSAMLI İN VİTRO KARAKTERİZASYON VE SALIM KİNETİK ÇALIŞMALARI
Authors: ÜNAL Sedat , DOĞAN Osman , AKTAŞ Yeşim
Published: September 2022

Amaç: Günümüzde kanser hala en sık görülen kronik hastalıklar arasında yer almaktadır. Polikaprolakton gibi biyouyumlu ve biyoparçalanır polimerlerle hazırlanan nanopartiküler ilaç taşıyıcı sistemler, düşük çözünürlük ve düşük biyoyararlanım gösteren birçok antikanser ajan için rasyonel bir çözümdür. Bu çalışmanın amacı, güçlü bir antikanser olduğu bilinen paklitaksel yüklü polikaprolakton nanopartiküllerinin hazırlanması ve hazırlanan nanopartiküllerin in vitro karakterizasyonlarını ve salım kinetik mekanizmalarını aydınlatmaktır. Gereç ve Yöntem: Nanoçöktürme yöntemi ile paklitaksel yüklü polikaprolakton nanopartiküllerinin hazırlanması amaçlanmıştır. Polikaprolakton polimerinin iki farklı moleküler ağırlığı (Mw: 14.000 ve Mw: 80.000) ile ön formülasyon çalışmaları yapılmıştır. Hazırlanan nanopartiküller, katyonik yüzey yükü elde etmek ve hücresel etkileşimi artırmak için Chitosan (CS) veya Poly-l-lisin (PLL) ile ayrı ayrı kaplanmıştır. Formülasyonların kapsamlı karakterizasyon çalışmaları ve salım kinetik çalışmaları yapılmıştır. Sonuç ve Tartışma: Formülasyonların partikül boyutu 188 nm ila 383 nm arasında değişmektedir. Enkapsülasyon etkinliği, farklı formülasyonlarda %77'ye kadar yükselmiştir. SEM analizi, nanopartiküllerin küre şeklinde olduğunu doğrulamıştır. İn vitro salım çalışmaları kapsamında 96 saate kadar salım devam etmiş ve ilk 24 saatte terapötik yükün %50'sinden azı salınmıştır. Matematiksel modelleme çalışmaları, formülasyonların salım kinetiğinin, yüksek korelasyon gösteren Korsmeyer-Peppas, Peppas-Sahlin ve Weibull modelleri ile birden fazla modele uyduğunu göstermiştir.
PELATIHAN MEDIA CANVA DALAM MENINGKATKAN LITERASI DIGITAL DAN KREATIVITAS ANAK DI DESA SUMBERJAYA
Authors: Abimanik Bena , Maulana Yoga Candra , Amin Amin
Published: September 2022

Education today must improve the quality of learning that is more innovative and creative. Learning media is one of the supporting components in learning, during this pandemic many schools are doing the learning process online because of social distancing restrictions that make the capacity of this school limited. The presentation of interesting, creative, and informative information or news is one of the capital to create information that is easily accepted by readers, in addition, learning media also affects students' learning interests, one example of learning media is by using infographics presented in a visual format. Therefore, the author held a Real Work Lecture Program containing Canva Media Training activities to improve digital literacy and creativity for children which will be held at Griya Pratama Bekasi RT / RW 001/034 Housing, Sumberjaya Village. This activity is carried out for 3 weeks. The goal is that with this training activity, the author wants to teach children who are in Griya Pratama Bekasi RT / RW 001 / 034 Housing, Sumberjaya Village has experience in designing. This activity has provided knowledge to the public/participants about the canva application which can be a reference for making infographic/poster designs, videos, logos, and even learning media as well. In addition, this training also improves the ability of participants in terms of innovative and creative skills.
MEMPERKENALKAN DAN MENUMBUHKAN MINAT WARGA DENGAN BERWIRAUSAHA MINUMAN EMPON-EMPON
Authors: Khofifah Lustia Husnul , Khatimah Husnul , Putra Purnama
Published: September 2022

Real Work Lecture (KKN) is a student service activity to the community that is carried out in an area. This activity is one of the subjects that must be taken by UNISMA students, KKN is also a form of student service through empowerment, training, counseling, mentoring, mentoring and to explore the potential that can be developed by the community. Based on this goal, the deployment of KKN students is expected to help the residents of Kranji Village, West Bekasi. There are 2 programs, namely the mandatory program (Supporting the prevention of violence and sexual harassment) and the elective program (introducing and growing people's interest in the Empon-empon beverage entrepreneurship). It is hoped that the local residents, especially teenagers and young mothers, can use their time to be more useful in terms of entrepreneurship and increase their knowledge in terms of preventing sexual harassment.
SOSIALISASI TENTANG PENANGANAN PERTAMA PADA CEDERA OLAHRAGA DI KELURAHAN UWUNG JAYA
Authors: Juliansyah Reno Rizki , Abidin Dindin , Mamesah Elly Diana
Published: September 2022

Penulisan ini dibuat untuk memberikan pemahaman dan gambaran kepada masyarakat luas dengan cara memberi edukasi atau langkah-langkah yang tepat khususnya untuk penanganan pertama pada cedera olahraga. Karena masih banyak masyarakat di sekitar kita yang masih belum paham bagaimana cara menangani cedera yang tepat khususnya tentang penanganan pertama jika terjadi cedera pada saat berolahraga. Kegiatan ini dilakukan dalam 4 tahapan dengan total 3 kegiatan inti, dengan kurun waktu pelaksanaan 15 hari yang dimulai dari tanggal 27 Februari 2022 – 12 Maret 2022 melalui zoom meet dengan jumlah 17 peserta dan whatsapp sebagai media komunikasi serta pemberian program lanjutan dengan peserta supaya lebih mudah untuk berkoordinasi antara pelaksana kegiatan dan peserta/remaja  RT 006 dan semua kegiatan dilaksanakan secara online. Tujuan  dari program ini adalah remaja RT006 Kelurahan Uwung jaya mendapatkan pemahaman yang baik dan benar sesuai dengan teori yang diberikan tentang penanganan pertama pada cedera olahraga, adapaun hasil atau dampak dari program ini yaitu remaja RT006 menjadi tahu bagaimana cara serta langkah awal penanganan pertama jika terjadi cedera dilingkungan RT 006 Kelurahan Uwung Jaya.
SOSIALISASI BUDIDAYA TANAMAN OBAT KELUARGA KEPADA MASYARAKAT LINGKUNGAN RW04 KEL.SEPANJANGJAYA, KEC.RAWALUMBU, KOTA BEKASI
Authors: Sugiarto Muhammad , Bahri Asep Saiful , Hermanto Hermanto
Published: September 2022

Family medicinal plants are plants that have many benefits, especially in the health sector. Cultivation of Family Medicinal Plants is a form of maintenance and care for the environment. Based on the Regulation of the Minister of Public Works Number 5 of 2008 concerning Guidelines for Provision and Utilization of Green Open Space in Urban Areas, each city is targeted to have 30 percent of green open space. Of 30 percent, 20 percent is public green open space and 10 percent is private green open space. According to the Head of the Controlling Office for Green Open Spaces, Ashari, in Bekasi, the green open space in Bekasi is only 15 percent and it is difficult to meet the 30 percent figure. In the regulation, there is a calculation of 10 percent of private green open space from urban green open space. So it is necessary to hold outreach activities or the habit of planting and caring for plants or trees in order to help the development of urban green open spaces through the habit of caring for the green environment to the community, especially in RW04 Kel. Sepanjangjaya Kec. Rawalumbu Bekasi City is carried out in the home environment. This activity will be held on March 16, 2022, in RW04 Kel. Sepanjangjaya Kec. Rawalumbu. This cultivation socialization activity will be carried out by methods in the form of counseling and delivery of plants in the form of seeds of Family Medicinal Plants as well as an understanding of how to care for and the benefits of these plants.
PENGARUH METODE DISKUSI TERHADAP KETERAMPILAN KOMUNIKASI SISWA PADA MATA PELAJARAN PENDIDIKAN AGAMA ISLAM DI SMK NEGERI 3 KOTA BEKASI
Authors: Devi Kasmiati , Irham Irham
Published: September 2022

This study aims to determine the effect of discussion methods on students’ communication skills.The method used in this research is an experimental research method with a Quasi-Experimentalmethod, with a Nonequivalent Control Group design which is a form of quasi-experimental or quasiexperimentalresearch methods. This study involved two classes, namely the experimental class andthe control class. Where the experimental class and the control class get the same learning in termsof assignments, content, teaching materials and learning time. The difference is in the treatmentgiven. The experimental class received teaching and learning treatment using the discussion method,while the control class used the lecture method. Data collection in the form of questionnaires anddocumentation. The sample used in this study amounted to 64 students. Where 32 students for theexperimental class and 32 students for the control class. he results of the study were shown by analyzingthe data using the formula “Paired sampe t-test”, then the results showed that t count> t table (9.976> 2.0395) with a significance level of 5%. And the resulting post-test mean score of the experimentalclass is 84.56 and the post-test mean score of the control class is 80.25. So, the post-test mean scoreof the experimental class is greater than the post-test mean score. -test control class. So the proposedhypothesis has been proven that the Discussion Method has an Influence on Student CommunicationSkills. This shows that the use of the discussion method has a positive effect on student communicationskills in Islamic education learning at SMK Negeri 3 Bekasi City.
UPAYA GURU PENDIDIKAN AGAMA ISLAM DALAM MENINGKATKAN SELF CONTROL SISWA DI SMA NEGERI 3 BEKASI
Authors: Komala Rika , Rizki Gunawan Akmal
Published: September 2022

This research is motivated by deviant behavior carried out by teenagers, especially students such as brawls, free sex, drug abuse, bullying, drunkenness, and so on. Most of the causes of this event is encouragement from peers. The purpose of this study was to determine the efforts of sIslamic Religious Education Teachers in increasing student self-control at SMA Negeri 3 Bekasi. With a qualitative descriptive method, this study tries to explore the extent to which a teacher can develop student self-control. The data collection techniques used were observation, interviews with Islamic Religious Education Teachers and documentation studies. The results showed that the teacher's efforts to improve student self-control were being uswah hasanah, making habituation, implementing joint supervision and mentoring policies and increasing discipline.
PENGARUH MEDIA FILM ANIMASI NUSSA DAN RARRA TERHADAP PENDIDIKAN KARAKTER SISWA
Authors: Lestari Suci Dwi , HS Abdul Khoir
Published: September 2022

Many moral declines occur, one of which is in the world of education, one of which is the use of smartphones in school children where they are easily influenced by trend developments through social media. So parents have to be extra in educating their children at home. In addition, the decline in ethics and morals that is happening at this time makes schools also strive to educate in order to realize the character education achieved. The government launched Strengthening Character Education (PPK) which can be integrated into the educational curriculum, one of which is through learning activities in schools using sophisticated and effective media. Researchers used the animated film Nussa and Rarra as a tool in the study. So this study aims to determine the effect of the animated film Nussa and Rarra on the character of students in PAI learning class IV SDN Karangsetia 03 Kab. Bekasi. This research is a quantitative research with the type of research design quasi experiment. With a population of all fourth grade students at SDN Karangsetia 03, the samples used were grades IV A and IV C. The data collection techniques used in this study were questionnaires and tests. The results obtained After being given treatment (treatment) and conducted a posttest. Character education of students is better using the animated film Nussa and Rarra compared to learning using power point media because it is more effective and varied, this is reinforced by the results of statistical tests assisted by SPPS version 25. The animated film media Nussa and Rarra has an effect on students' character education because the animated film Nussa and Rarra is not only funny but contains character education values ​​in each episode, then the role of the character has the potential to be imitated by children or become role models and this animated film contains a religious theme that is thick with the adab and behavior of a Muslim. The results of the attitude assessment must be understood as a process not as the result of an instant learning process that is assessed by educators every time they complete the learning process. Therefore, this assessment is an accumulative process or will continue to develop on student behavior indefinitely.
SEJARAH DAN PERKEMBANGAN MADRASAH DI INDONESIA
Authors: Samsudin Mohamad , Haniefa Rifda
Published: September 2022

Madrasa is one form of Islamic educational institution that has gone through a long evolutionary process. Starting from the mosque which was used as a means of education, then kuttab, and so on turned into a madrasa. The process of evolution of the madrasa to become an educational institution that is recognized as capable of producing a superior generation of Islam, of course, has not escaped the long journey of history that it has gone through with challenges. Until finally the madrasa arrived at the archipelago, the historical carvings inscribed by Islamic leaders were also full of exhausting struggles. From then until now, and maybe until when, can not be determined. This paper is intended to find out how the history of madrasa, from classical to modern times, from the Middle East to Indonesia, and the challenges faced for its existence. In this study, the authors use research that is library research using written materials that have been published in the form of books and international journals. This research uses a historical and educational approach. The results of the research in this study indicate that in the history of the growth and development of madrasa in Indonesia, there are two momentums that determine the existence of madrasa: first, the 1975 Joint Decree of Three Ministers (SKB 3 Menteri) which became the entry point for the recognition of madrasa as Islamic educational institutions that is equivalent to public schools; second, the National Education System Law Number 2/1989 which makes madrasa not only educational institutions that is equivalent to public schools, more than that, madrasa is recognized as public schools with Islamic characteristics. In other words, madrasa can be said to be "plus public school". On the other hand, this recognition is a matter of pride for the madrasa, but on the other hand it is also a challenge that needs to be proven, whether the madrasa is able to carry out this dual status.
Динамический метод расчета производственных зданий на действие взрывной волны
Authors: КЕЛАСЬЕВ Николай Геннадьевич , АВДЕЕВ Кирилл Владимирович , ЛЕВИН Дмитрий Иванович
Published: September 2022

В статье приводятся сведения о параметрах нагрузок от действия взрыва при взаимодействии с отдельно стоящим зданием. Выполнен расчет одноэтажного производственного здания по первому предельному состоянию, которое характеризуется работой конструкций в условно-упругой стадии деформирования, по двум методикам. Представлен алгоритм расчета железобетонных конструкций на действие взрывной нагрузки с учетом дифракции квазистатическим методом, а также динамическим методом при помощи расчетного комплекса ЛИРА 10 - методом прямого интегрирования уравнений движения. Проведен сравнительный анализ частот собственных колебаний конструкций, перемещений и усилий, полученных квазистатическим и динамическим методами расчета на взрывные нагрузки. Сделаны выводы о преимуществах и перспективах применения динамического метода расчета производственных зданий при взрывных нагрузках с использованием отечественных расчетных комплексов.
Тепловые потери через сопряжения трехслойных стен с железобетонными перекрытиями
Authors: ВАСИЛЬЕВА Терентий Афанасьевич , ВАСИЛЬЕВА Анна Терентьевна
Published: September 2022

В результате тепловизионных обследований каркасно-монолитного здания в Якутске установлены характерные участки нарушения тепловой защиты в наружных ограждающих конструкциях. Температура на внутренней поверхности сопряжения трехслойной стены с междуэтажным перекрытием на участках расположения балкона, несмотря на наличие перфорации, ниже температуры точки росы внутреннего воздуха. Теплотехнические расчеты трехмерной модели участка перекрытия подтвердили низкую температуру на внутренней поверхности. Отрицательное влияние на температурный режим оказывает протяженный участок перекрытия с колонной прямоугольной формы. Особенно низкая температура наблюдается на угловых участках цокольного перекрытия с колонной. На данном участке имеется объемный "мостик холода": железобетонный ростверк - колонна - цокольное перекрытие - стена из мелких камней.
The Retrospective Raj
Authors: Goodman Sam
Published: September 2022

The Retrospective Raj: Medicine, Literature & History After Empire undertakes a detailed analysis of the use of medicine as a recurrent and defining trope of post-imperial fiction published between 1950 and 1990. The book argues that during this crucial period of recent history, when the influence and prestige of the British Empire was nearing its end, a range of contemporary novelists including J. G. Farrell, Paul Scott, John Masters, Ruth Prawer Jhabvala, and Salman Rushdie identified and used medicine as a discursive paradigm through which to engage critically with the history, authority and legacy of the British Empire within their writing. Drawing on a range of literary and archival sources, this project explores the complex relationship between Britain, India and Empire through a medical humanities lens, bringing together the concerns of literary study and medical history under an interdisciplinary and original methodological framework. The Retrospective Raj is the first book of its kind to explore the 20th century literary revival of Empire and the post-imperial novel through the critical medical humanities. It approaches the novels of a defining group of post-war authors and Booker Prize winners through comparative analysis, considering how they used medical history, and medical themes and metaphor to ask searching questions about how the real and imagined history of Empire continued to inform British identity long after its ending.
The Fragility of Concern for Others
Authors: Ferrarese Estelle
Published: September 2022

The book’s underlying project is to renew and sharpen Critical Theory through feminism. It aims to develop our thinking about the social conditions of caring for others, while arguing for an understanding of morality that is materialist and political – always-already political.
Offering the first systematic study of the idea of “coldness” in Adorno’s philosophy, Ferrarese’s book is the first to stage a dialogue between Adornian Critical Theory and the ethics of care. It thereby endeavours to think through the mechanisms of the social fragility of caring for others, the moral gesture it enjoins, as well as its political stakes. In so doing, it is able to approach old question in a new light in a bid to give dignity to the singular, to make heard its specific claims, its moral pertinence. It explains how the capitalist form of life produces certain moral attitudes and it shows that the capitalist form of life, strained by a generalised indifference, nevertheless produces a compartmentalised attention to others, one limited to very particular tasks and domains and attributed to women. Finally, it shows that even though caring for others has historically burgeoned in specific conditions of subordination (those of gender notably), this by no means permits us to conclude as to the vacuity of its normative content.
Humour in the Letters of Thomas Campbell
Authors: Wilcockson Amy
Published: September 2022

Humour within the letters and personal writings of Romantic poets and authors has remained relatively neglected. Similarly seldom studied is the Scottish Romantic poet Thomas Campbell (1777–1844). Calling into question John Anster’s assessment of Campbell’s letters as a ‘weary heap of good-for-nothing evidence’, this article will attempt to give his unpublished epistles their rightful prominence in studies of Romanticism. Campbell’s correspondence reveals humorous descriptions of cooks kicking cats, which jostle with declarations of explicit disgust against ‘second-rate writers’, and detailed accounts of Campbell’s numerous illnesses. By shedding light on the use of humour in his letters, this article will challenge current preconceptions of Campbell, and show how he used humour to forge and maintain relationships in both his personal and his business correspondence.
Laughing with Young Ben: Vivian Grey, Flim-Flams!, and the Perplexities of Satirical Writing
Authors: Villa Luisa
Published: September 2022

From his unpublished juvenilia to The Young Duke (1831), Benjamin Disraeli tested his literary potential mainly through writing in the satirical, comic, or even farcical mode. One way or another, all his fictional works from 1826 to 1830 were meant to make people laugh, or at least smile, and appreciate the young author’s wit and humorous talent for irony and comic exaggeration. He sidelined this practice in the 1830s, when he mainly experimented with other narrative genres and modes of representation, eventually parading in Venetia (1837) a new sobriety of tone such as suited an aspiring Tory politician in the year of Victoria’s accession.

Working within this developmental framework, my article sets out to investigate the young Disraeli’s penchant for laughter in connection with the fun-loving vein running in the family. It focuses on Vivian Grey, Part I, and relates it to Flim-Flams!, or, the Life and Errors of My Uncle and the Amours of My Aunt (1805), a quirky satirical ‘romance’ Isaac D’Israeli completed round about the time his eldest son was born. In highlighting the contextual similarities and carnivalesque qualities of the two works, the article offers an eccentric approach to the Romantic/early-Victorian generational changeover.
ANALYSIS OF THE TECHNICAL STATE OF HYDROTECHNICAL STRUCTURES OF TRANSPORTATION CONSTRUCTION FROM ROAD WATER PERFORMANCE PIPES FROM THE INFLUENCE OF CORROSION
Authors:   National Transport University, Нarkusha Mykola , Klymenko Mykola ,   National Transport University, Onyshchenko Artur ,   National Transport University
Published: September 2022

Hydrotechnical structures of transport construction from road culverts are designed for transporting and diverting water from transport structures. One of the main factors affecting the durability of a road culvert is corrosion of the metal of the pipe itself. With the increase in the number of hydraulic engineering structures of transport construction from road culverts on roads, the issue of ensuring the reliability and durability of their operation during operation becomes of particular importance, as there is a large number of deformations, as well as cases of complete destruction of pipes under embankments. World experience shows that corrosion damage is an extremely important problem and requires an appropriate response at a very early stage of development.
COMPETITIVE ADVANTAGES AS CRITERIA FOR SELECTION OF THE WINNER OF PUBLIC PROCUREMENT IN THE BRIDGE CONSTRUCTION INDUSTRY OF UKRAINE (BASED ON ADAPTATION OF JAPANESE EXPERIENCE)
Authors:   National Transport University, Borysenko Yevheniia
Published: September 2022

The article examines the need to expand the possibilities of using the competitive advantages of enterprises of the bridge construction industry of Ukraine in public procurement, based on adaptation to the Japanese experience. It was found that in Ukraine, the main criterion for selecting the winner of public procurement in the bridge construction industry is a low price and a set of standard criteria that the bidding company must have. The possibilities of the Japanese experience of competitive bidding in the bridge construction industry are considered. During the research, common characteristics with Ukraine and additional opportunities in the use of competitive advantages of companies during public procurement in bridge construction were revealed. The need to develop feedback with bidders for the implementation of the transfer of innovative technologies in the construction of bridges in Ukraine, based on the Japanese methods of selecting the winner "technical proposal, integrated evaluation system" and "value engineering (VE) system" was established. The need to introduce competitive bidding in the field of bridge construction in Ukraine into a separate selective form of bidding, with the possibility of using different methods of selecting the winner, based on the Japanese experience, was revealed.
FORMATION AND DEVELOPMENT OF INTELLECTUAL CAPITAL AS A PREREQUISITE FOR INCREASE OF COMPETITIVENESS POTENTIAL OF THE ENTERPRISE
Authors:   National Transport University, Haidai Hanna , Dudka Tamara ,   National Transport University, Petrovska Svitlana ,   National Transport University, Shvets Lyudmila ,   National Transport University
Published: September 2022

The article considers the directions of intensification of personnel activity as a factor of increase of innovative activity of enterprises and growth of their competitiveness. The purpose of the article is to outline the areas of purposeful development of enterprise personnel - using innovative approaches - to increase their intellectual activity and competitiveness. The results are obtained due to the application of methods of analysis and synthesis, abstraction, systematization, generalization and systems approach. The article emphasizes that due to the growing requirements for the educational and qualification level of employees of enterprises and organizations, increasing the competitiveness of both individual employees and enterprises should occur due to the development of personal competencies of individual employees in parallel with the development of corporate competence of staff as a whole. Competitive enterprises implement programs of "continuous professional development of staff". It is substantiated that in order to activate the personnel of enterprises, the management should use innovative approaches to the management of personnel development and corporate culture: tools for the development of leadership competencies; the latest effective personnel technologies (development, training, loan work, etc.); holacratic principles of management in organizations with a "flat hierarchy". An innovative and non-standard approach to personnel development management in corporations can be used by the management of enterprises to improve the processes of personnel development and intensify its innovative activities.
Phytochemical, Antioxidant and Antiproliferative Properties of Linum usitatissimum (Flax) Seed Extract
Authors: Prasath G. Sriram , Rebellow M. Maria Caroline , Muthumani G. Durai , Divya M.  , Satya Sri P.  , Prakash M.V. Dass
Published: September 2022

In animal studies, flaxseed (Linum usitatissimum) is one of the most widely examined diets for possible ties to breast cancer, although clinical data is sparse. Antioxidant and anti-proliferative effects of flaxseeds were examined in this study. Dried seed extracts included 20.4± 0.48 mg GAE and 3.4±0.55 mg QE, respectively in the phytochemical analysis, as well as flavonoids, tannins, carbohydrate, proteins, and amino acids, as well as anthraquinones, phenols, coumarin, and quinones. Nutritional analysis of seed extract from L. usitassimum indicated that it contained 18.4 g protein; 31 g of carbohydrate and 38.5 g fat. L. usitassimum seed extract scavenged 83% of DPPH radicals at a concentration of 1000 g/ml. The IC50 value was discovered to be 638.70 g/ml. At a concentration of 1000 g/ml, 81 per cent of the ABTS radical was scavenged, and the IC50 value was 679.77 g/ml. More than 86% of cell growth was inhibited at the highest dosage of ethanolic extract (20-200 g/ml). MCF7 breast cancer cells were significantly suppressed by ethanolic extract of L. usitassimum.
Sum of Successive Partitions of Binomial Coefficient
Authors: Annamalai Chinnaraji
Published: September 2022

This paper focuses on the successive partition method applied to a binomial coefficient in combinatorial geometric series. The coefficient for each term in combinatorial geometric series refers to a binomial coefficient. These ideas can enable the scientific researchers to solve the real life problems.
The Holy Grail of Mathematics
Authors: Vega Frank
Published: September 2022

A trustworthy proof for the Riemann hypothesis has been considered as the Holy Grail of Mathematics by several authors. The Riemann hypothesis is a conjecture that the Riemann zeta function has its zeros only at the negative even integers and complex numbers with real part $\frac{1}{2}$. Let $Q$ be the set of prime numbers $q_{n}$ satisfying the inequality $\prod_{q \leq q_{n}} \frac{q}{q-1}>e^{\gamma} \cdot\log\theta(q_{n})$ with the product extending over all prime numbers $q$ that are less than or equal to $q_{n}$, where $\gamma\approx 0.57721$ is the Euler-Mascheroni constant, $\theta(x)$ is the Chebyshev function and $\log$ is the natural logarithm. If the Riemann hypothesis is false, then there are infinitely many prime numbers $q_{n}$ outside and inside of $Q$. In this note, we obtain a contradiction when we assume that there are infinitely many prime numbers $q_{n}$ outside of $Q$. By reductio ad absurdum, we prove that the Riemann hypothesis is true.
An open microfluidic coculture model of fibroblasts and eosinophils to investigate mechanisms of airway inflammation
Authors: Zeng Yuting , Su Xiaojing , Takezawa Meg G. , Fichtinger Paul S. , Lee Ulri N. , Pippin Jeffery W. , Shankland Stuart J. , Lim Fang Yun , Denlinger Loren C. , Jarjour Nizar N. , Mathur Sameer K. , Sandbo Nathan , Berthier Erwin , Esnault Stephane , Bernau Ksenija , Theberge Ashleigh B.
Published: September 2022

Interactions between fibroblasts and immune cells play an important role in tissue inflammation. Previous studies have found that eosinophils activated with interleukin-3 (IL-3) degranulate on aggregated immunoglobulin G (IgG) and release mediators that activate fibroblasts in the lung. However, these studies were done with eosinophil-conditioned media that have the capacity to investigate only one-way signaling from eosinophils to fibroblasts. Here, we demonstrate a coculture model of primary normal human lung fibroblasts (HLFs) and human blood eosinophils from patients with allergy and asthma using an open microfluidic coculture device. In our device, the two types of cells can communicate via two-way soluble factor signaling in the shared media while being physically separated by a half wall. Initially, we assessed the level of eosinophil degranulation by their release of eosinophil-derived neurotoxin (EDN). Next, we analyzed the inflammation-associated genes and soluble factors using reverse transcription quantitative polymerase chain reaction (RT-qPCR) and multiplex immunoassays, respectively. Our results suggest an induction of a proinflammatory fibroblast phenotype of HLFs following the coculture with degranulating eosinophils, validating our previous findings. Additionally, we present a new result that indicate potential impacts of activated HLFs back on eosinophils. This open microfluidic coculture platform provides unique opportunities to investigate the intercellular signaling between the two cell types and their roles in airway inflammation and remodeling.
Genetically encoded fluorescent biosensors for GPCR research
Authors: Kim Hyunbin , Baek In-Yeop , Seong Jihye
Published: September 2022

G protein-coupled receptors (GPCRs) regulate a wide range of physiological and pathophysiological cellular processes, thus it is important to understand how GPCRs are activated and function in various cellular contexts. In particular, the activation process of GPCRs is dynamically regulated upon various extracellular stimuli, and emerging evidence suggests the subcellular functions of GPCRs at endosomes and other organelles. Therefore, precise monitoring of the GPCR activation process with high spatiotemporal resolution is required to investigate the underlying molecular mechanisms of GPCR functions. In this review, we will introduce genetically encoded fluorescent biosensors that can precisely monitor the real-time GPCR activation process in live cells. The process includes the binding of extracellular GPCR ligands, conformational change of GPCR, recruitment of G proteins or β-arrestin, GPCR internalization and trafficking, and the GPCR-related downstream signaling events. We will introduce fluorescent GPCR biosensors based on a variety of strategies such as fluorescent resonance energy transfer (FRET), bioluminescence resonance energy transfer (BRET), circular permuted fluorescent protein (cpFP), and nanobody. We will discuss the pros and cons of these GPCR biosensors as well as their applications in GPCR research.
Leucophyllum frutescens mediated synthesis of silver and gold nanoparticles for catalytic dye degradation
Authors: Gami Bansuri , Bloch Khalida , Mohammed Shahansha M. , Karmakar Srikanta , Shukla Satyajit , Asok Adersh , Thongmee Sirikanjana , Ghosh Sougata
Published: September 2022

The application of nanotechnology is gaining worldwide attention due to attractive physico-chemical and opto-electronic properties of nanoparticles that can be also employed for catalytic dye degradation. This study reports a phytogenic approach for fabrication of silver (AgNPs) and gold nanoparticles (AuNPs) using Leucophyllum frutescens (Berl.) I. M. Johnst (Scrophulariaceae) leaf extract (LFLE). Development of intense dark brown and purple color indicated the synthesis of AgNPs and AuNPs, respectively. Further characterization using UV-visible spectroscopy revealed sharp peak at 460 nm and 540 nm for AgNPs and AuNPs, respectively that were associated to their surface plasmon resonance. High resolution transmission electron microscope (HRTEM) revealed the spherical shape of the AgNPs, whereas anisotropic AuNPs were spherical, triangular and blunt ended hexagons. The majority of the spherical AgNPs and AuNPs were ∼50 ± 15 nm and ∼22 ± 20 nm, respectively. Various reaction parameters such as, metal salt concentration, temperature and concentration of the leaf extract were optimized. Maximum synthesis of AgNPs was obtained when 5 mM for AgNO3 reacted with 10% LFLE for 48 h at 50°C. Likewise, AuNPs synthesis was highest when 2 mM HAuCl4 reacted with 10% LFLE for 5 h at 30°C. Energy dispersive spectroscopy (EDS) showed phase purity of both the nanoparticles and confirmed elemental silver and gold in AgNPs and AuNPs, respectively. The average hydrodynamic particles size of AgNPs was 34.8 nm while AuNPs was 140.8 nm as revealed using dynamic light scattering (DLS) that might be due to agglomeration of smaller nanoparticles into larger clusters. ZETA potential of AgNPs and AuNPs were 0.67 mV and 5.70 mV, respectively. X-ray diffraction (XRD) analysis confirmed the crystallinity of the nanoparticles. Fourier transform infrared spectroscopy (FTIR) confirmed that various functional groups from the phytochemicals present in LFLE played a significant role in reduction and stabilization during the biogenic synthesis of the nanoparticles. The bioreduced AgNPs and AuNPs catalytically degraded Rhodamine B dye (RhB) in presence of UV-light with degradation rate constants of 0.0231 s−1 and 0.00831 s−1, respectively. RhB degradation followed a first order rate kinetics with 23.1 % and 31.7% degradation by AgNPs and AuNPs, respectively.
Synthesis, docking studies, biological activity of carbon monoxide release molecules based on coumarin derivatives
Authors: Liu Huapeng , Chen Yujie , Cui Fujun , Liao Yuan , Wang Xicun
Published: September 2022

In the present work, we synthesized seven complexes. All complexes were identified by ESI-HRMS, 1H-NMR, 19F-NMR and 13C-NMR spectroscopies. The synthesized complexes were tested for their anticancer activities in vitro against three different human cell lines, including breast MDAMB231, cervical Hela, liver HepG2. IC50 values of complexes 1-7 were 34.98–667.35 µM. Complex 5 revealed higher sensitivity towards MDAMB231 cells with IC50 values 34.98 μM in comparison to 5-FU as positive control. Moreover, complex 5 caused a decrease of mitochondrial membrane potential and effectively induced ROS production against MDAMB231 cells. Western blot analysis showed that complex 5 could up-regulate the expression of Bax protein and down-regulate the expression of Bcl-2, activate Caspase-3, slightly down-regulate the expression of HO-1. The docking studies showed that complex 5 could be interacted with Bcl-2 protein through hydrophobic interactions, hydrogen bonds and salt bridges to enhance the binding affinity. All the analyzed coumarins obeyed the Lipinski’s rule of five for orally administered drugs. Based on the aforementioned results, it suggests that the complex induced apoptosis cell via mitochondria pathways. Collectively, complex 5 could be considered as a promising hit for new anti-breast cancer agents. Carbonyl cobalt CORMs, as potential anticancer therapeutic agents, provided a new idea for the development of metal anticancer drugs.