bluuebunny/crossref_metadata_2025 huggingface dataset:
Nuevos desafíos en el desarrollo de vacuna antirrábica
Authors: Cruzat Bastian A , Villaseca Diego A , Arata Loredana , Nuñez Ninoska M , Vasquez Abel Eduardo
Published: August 2022

La rabia es una zoonosis milenaria y la mayoría de los países desarrollados están libres de muerte humana por rabia transmitida por perros, pero la realidad es diferente a países de ingresos bajos y medios, donde es un problema de salud pública. En Chile estamos libres de rabia transmitida por animales domésticos y en los últimos años se han reportado casos muy esporádicos, pero que no han evolucionado a la muerte.Para el control de la rabia, existen una variedad de vacunas humanas y veterinarias, que se aplican en diferentes países y en Chile se dispone de mas de una opción de vacunas humanos y veterinarias, pero existe un desafío en la vacunación de la fauna silvestre, donde se encuentra el reservorio del virus de la rabia, específicamente en los murciélagos, donde la disponibilidad de una vacuna es un desafío por abordar y sería un gran aporte para la erradicación de los reservorios silvestres del virus de la rabia.Las vacunas mucosales en base a probióticos recombinantes que expresen proteínas del virus de la rabia se proyectan como una atractiva alternativa a evaluar para el desarrollo de una vacuna destinada a la vacunación de animales silvestres.
Pandemia por SARS-CoV-2: patogenia del COVID-19 en pacientes que padecen hipertensión, diabetes mellitus, obesidad y déficit de Vitamina D
Authors: Barriga Sanhueza Claudio , Cepeda Kehr Joaquín , Cifuentes Carrillo Claudio , Lepe Venegas Hugo , Garay Catalan Yosselyn , Araya  Gutierrez Katherine
Published: August 2022

El SARS-CoV-2 es un Betacoronavirus causante de la enfermedad conocida como COVID-19, la que ha provocado una pandemia vinculada a numerosos decesos y un alto porcentaje de pacientes infectados con una serie de complicaciones, principalmente, en aquellos que presentan comorbilidades previas como hipertensión, diabetes mellitus y obesidad. Esto debido a que dichos pacientes poseen una condición inflamatoria basal, que puede agravar la infección, al exacerbar la respuesta inflamatoria del organismo. Lo anterior se produce porque la unión viral a enzima convertidora de angiotensina II conduce a un aumento en las concentraciones de angiotensina II, la cual posee efectos proinflamatorios y vasoconstrictores que resultan en una mayor producción de citoquinas proinflamatorias y especie reactivas de oxígeno, generando una exacerbación de la respuesta inflamatoria, sumado al hecho de que en pacientes con COVID-19 grave hay una respuesta inmune deficiente, lo que también aumenta las citocinas proinflamatorias, agravando el pronóstico de los pacientes. Además, existen factores epidemiológicos que pueden influir en la gravedad de la enfermedad como los niveles de vitamina D y edad. La presente revisión se enfoca en la comprensión de la patogenia en pacientes COVID-19, principalmente en los que presentan comorbilidades, además, en las alteraciones de la respuesta inmunológica, características epidemiológicas y modificaciones epigenéticas que favorecen el desarrollo de complicaciones en el organismo durante la infección.
Inovação pedagógica como estratégia de contextualização da escola do campo
Authors: Leal Rosana de Castro , Reis Edmerson dos Santos
Published: August 2022

As metodologias de aprendizagem são instrumentos técnicos indispensáveis ao desenvolvimento de um campo educacional eficiente e inovador. É nesse sentido que a educação contextualizada, proposta por Paulo Freire, inspirou o trabalho aplicada com sucesso pela Escola Rural de Massaroca. Com o objetivo de identificar os elementos que distinguem essa experiência, analisamos a proposta pedagógica da instituição. A metodologia da Análise de Conteúdo foi o meio de sistematização dos dados, os quais resultaram em três categorias que representam os eixos da práxis pedagógica. Dessa forma, o desfecho representa uma sucinta análise do plano teórico que contextualiza a cultura local, com seus valores e signos, publicizando uma significativa experiência de ensino-aprendizagem.
Implementação da filosofia de melhoria contínua no processo de distribuição de bebidas, por meio do ciclo PDCA: estudo de caso de uma distribuidora de bebidas
Authors: Resende Maria Eduarda Nascimento , Pantuza Guido
Published: August 2022

Para que os negócios se mantenham viáveis, reduzir custos logísticos e melhorar os padrões de atendimento são fatores cruciais que devem ser levados em consideração na tomada de decisões, uma vez que estes pode ter impacto direto ou indireto no futuro das organizações, pois afetam na competitividade, participação no mercado e resultados financeiros e econômicos. Este trabalho trata do monitoramento e controle do processo de entregas em uma distribuidora de bebidas cuja sua responsabilidade era distribuir cervejas, refrigerantes e isotônicos da cervejaria Ambev na cidade de Governador Valadares – MG e toda região do Vale do Rio Doce. Este processo está sujeito a ocorrências que não estão sob controle, tais como o trânsito, clima, atrasos pela ausência do comprador no local de entrega. Devido a estas ocorrências, mesmo com um roteiro de entregas otimizado, nem sempre é possível cumpri-lo, o que aumenta os custos com as entregas. Por isso, este trabalho se propõe a realizar um estudo com o objetivo de implementar uma metodologia de melhoria contínua do processo de entregas, por meio da ferramenta conhecida como Ciclo PDCA para redução dos custos com as entregas. Ainda, para um maior controle do processo, os parâmetros estatísticos, correlação e gráficos de dispersão, também são usados para identificar e medir o impacto das medidas de desempenho adotadas pela empresa. Com isso os resultados obtidos neste trabalho mostraram satisfatório e com isso houve uma diminuição nos custos com manutenção e combustível.
A Janela de Johari e o desenvolvimento das competências socioemocionais: algumas notas analíticas
Authors: Silva Eneias Nunes da , Santos Alexsandro do Nascimento
Published: August 2022

Esta comunicação cientifica apresenta resultados parciais de uma investigação cujo objetivo é descrever, interpretar e analisar as relações entre o desenvolvimento das capacidades ou competências socioemocionais com o auxílio da Janela de Johari nos processos de ensino e aprendizagem. Para tanto, assumem-se o referencial do conceito denominado Janela de Johari e os pressupostos da teoria psicogenética do desenvolvimento humano formulada por Henri Wallon. Nesta primeira fase do estudo, nos debruçamos sobre a análise dos elementos principais da Teoria da Janela de Johari para, posteriormente, discutir nossas hipóteses a respeito de suas implicações para as práticas pedagógicas na educação básica. Para este artigo foram consultadas as bases de dados da Scientific Electronic Library Online (SciELO) e da Biblioteca Digital de Teses e Dissertações – BDTD. Os resultados alcançados permitem afirmar que a presença dos estudos sobre a janela de Johari é restrita, convocando os pesquisadores do campo à uma reflexão mais sistemática e estruturada a respeito de seus pressupostos e de seu potencial para o desenvolvimento das capacidades ou competências socioemocionais.
Incremental sheet forming parameters and applications: a review
Authors: Schreiber Rafael Gustavo , De Sousa Adriellen Lima , Dos Santos Euller Mendonça , Fiuza Filho Fernando , Norberto Júlio César , Mondo Lucas Santos Savi , Cabral Thainara Hamerski , Schaeffer Lirio
Published: August 2022

The present work introduces a literature review on the Incremental Sheet Forming process application and main parameters. This process is used to manufacture small batches of parts and formed sheets prototypes, as a semi-spherical-tipped tool yields form to a sheet using a pre-defined trajectory and various step-downs (Δz). In this work we describe the Incremental Sheet Forming process variations, application examples, the types of machines used and the diagram characteristics that describe the formed material’s strain limits. The article also presents a detailed study on the influence of the main strength parameters required to execute the process, material formability, surface finishing and final product accuracy.
Vacinas e vacinação contra COVID-19: estado da arte
Authors: Cavilha Lucas Grunvald , Bechtold Caio
Published: August 2022

A vacinação contra a COVID-19 toma proporções gigantescas, além disso, foram elaborados diferentes tipos de vacinas com tecnologias distintas, como as vacinas de vetores virais, assim como vacinas proteicas e genéticas, sendo que estas envolvem  maior grau de complexidade. A necessidade de um estudo a partir desse cenário de vacinação global faz um melhor entendimento a partir de dados sobre acertos, erros, previsões, entre outras perspectivas, visando que a vacinação total contra SARS-CoV-2 seja de caráter urgente pois são afetados aspectos básicos de sobrevivência da espécie humana. Pelo fato de a fabricação de vacinas eficazes e seguras contra a COVID-19 não ser fácil, o manejo, transporte, administração e distribuição também se tornam um grande desafio. Com o avanço diário da vacinação contra SARS-CoV-2 e suas variáveis mudanças de perspectiva, esta revisão busca trazer em base de dados epidemiológicos uma análise e discussão do que já foi feito, do que poderá ser feito como melhoria, das perspectivas e possíveis previsões em âmbito mundial e nacional.
Smartphone-Based Photoelectrochemical Immunoassay with Co
9
S
8
@ZnIn
2
S
4
for Point-of-Care Diagnosis of Breast Cancer Biomarker
Authors: Zeng Ruijin , Li Yuxuan , Li Yanli , Wan Qing , Huang Zhisheng , Qiu Zhenli , Tang Dianping
Published: August 2022

Photoelectrochemical immunoassays incorporating specific antigen-antibody recognition reactions with the photon-electron conversion capabilities of photocatalysts have been developed for biomarker detection, but most involve bulky and expensive equipment and are unsuitable for point-of-care testing. Herein, a portable smartphone-based photoelectrochemical immunoassay was innovatively designed for the on-site detection of breast cancer biomarkers (human epidermal growth factor receptor 2; HER2). The system consists of a split-type immunoassay mode, disposable screen-printed electrode covered with hierarchical Co
9
S
8
@ZnIn
2
S
4
heterostructures, an integrated circuit board, and a Bluetooth smartphone equipped with a specially designed app. Using alkaline phosphatase (ALP) catalytic strategy to in situ generate ascorbic acid (AA) for electron-donating toward Co
9
S
8
@ZnIn
2
S
4
heterostructures, an immunoreaction was successfully constructed for the HER2 detection in the real sample due to the positive correlation of the photocurrent signal to electron donor concentration. Differential charge density indicates that the formation of Co
9
S
8
@ZnIn
2
S
4
heterojunction can facilitate the flow of charges in the interface and enhance the photocurrent of the composite. More importantly, the measured photocurrent signal can be wirelessly transmitted to the software and displayed on the smartphone screen to obtain the corresponding HER2 concentration value. The photocurrent values linearly with the logarithm of HER2 concentrations range spanned from 0.01 ng/mL to 10 ng/mL with a detection limit of 3.5 pg/mL. Impressively, the clinical serum specimen results obtained by the proposed method and the wireless sensing device are in good agreement with the enzyme-linked immunosorbent assay (ELISA).
Designing Zinc Deposition Substrate with Fully Preferred Orientation to Elude the Interfacial Inhomogeneous Dendrite Growth
Authors: Xie Chunlin , Yang Zefang , Zhang Qi , Ji Huimin , Li Yihu , Wu Tingqing , Li Wenbin , Wu Pengfei , Wang Haiyan
Published: August 2022

The development of zinc-ion batteries with high energy density remains a great challenge due to the uncontrollable dendrite growth on their zinc metal anodes. Film anodes plated on the substrate have attracted increasing attention to alleviate these dendrite issues. Herein, we first point out that both the random crystal orientation and the low metal affinity of the substrate are important factors of zinc dendrite formation. Accordingly, the (1 0 1) fully preferred tin interface layer with high zinc affinity was fabricated by chemical tin plating on (1 0 0) oriented copper. This tin decorated copper substrate can realize high reversible zinc plating/stripping behavior, and full cell using this zinc plated substrate can be operated for more than 1000 cycles with high capacity retention (85.3%) and low electrochemical impedance. The proposed strategy can be also applied to lithium metal batteries, which demonstrates that the substrate orientation regulation and metal affinity design are the promising approaches to achieve dendrite-free metal anode and overcome the challenges of highly reactive metal anodes.
Risk Factors of Cardiovascular Disease as Predictors of Cardiomotor Profiles in Hispanic-Latinos Living with HIV
Authors: Orozco Elizabeth , G Rosario Martin
Published: August 2022

Background: People living with HIV are at increased risk of developing cardiovascular disease. Risk factors associated with cardiovascular disease negatively impact cardiovascular and muscular function. Therefore, this study aims to determine if cardiovascular disease risk factors are predictors of cardiomotor profiles in Hispanic-Latinos living with HIV. Subjects: A total of 176 participants were enrolled in this study. There were 134 males and 42 females with a mean age of 53.34 +/- 10.31 years old. Methods: Data was collected retrospectively from people living with HIV in San Juan, Puerto Rico from 2000-2020. Cardiovascular disease risk factors were collected by interview. In addition, the cardiovascular and locomotor components were collected using the Ross submaximal exercise test. Results: Hyperlipidemia was a significant predictor of treadmill time (B= -1.882, p=.034) and heart rate (B= -6.878, p<.001), whereas hypertension was a predictor of heart rate (B= -12.903, p=.026) and systolic blood pressure (B=12.263, p<.001). Hyperlipidemia was also a significant predictor of inclination (B= -1.707, p=.034). In addition, 57.4 % of the sample had at least one cardiovascular disease risk factor. Conclusion: Hyperlipidemia and hypertension should be considered in managing people living with HIV. This study indicated that hyperlipidemia and hypertension negatively affect cardiovascular and locomotor performance during exercise. Clinicians should be aware that exercise tolerance may be reduced in people with HIV and CVD risk factors; therefore, exercise prescription should be tailored and monitored accordingly.
Preserving New Zealand's Voices of World War II
Authors: Ditchburn Sandy
Published: August 2022

During World War II, the Mobile Broadcasting Unit of New Zealand's armed forces recorded interviews and reports about the fighting and the day-to-day business of war, as well as thousands of simple messages home from servicemen, and a few women. Today, the 1600 surviving Mobile Unit discs form part of the sound archives of Radio New Zealand, held by audiovisual archive Ngā Taonga Sound & Vision. In this "sidebar" article which is a companion piece to "Voices from the War," the author describes some of the challenges she has encountered in capturing sound from the 80-year-old lacquer discs in the Mobile Broadcasting Unit collection.
Analysis Of The Need And Demand For Health Services At The Marsabut Lake Health Center, South Tapanuli Regency In The Jkn Era
Authors: Rambe Normayanti
Published: August 2022

The phenomenon of people preferring to seek treatment abroad instead of using domestic health services is a big challenge. This challenge can be answered by improving quality in all fields, especially the health sector. So, this is what will help health service providers in setting strategies to meet the needs of the community in the health sector. The purpose of the study was to determine the need, demand, and utility of public health services in the work area of the Marsabut Lake Health Center, South Tapanuli Regency. Types of quantitative research with a cross-sectional approach. The population is a community living in the working area of Lake Marsabut, South Tapanuli Regency. With a sample number of 60 people. The study was conducted in June 2022. The results of research related to need showed that the main needs of respondents related to health service facilities were quality and distance ≤ 3 km. Community demand is dental poly and general poly services provided by Marsabut Lake, South Tapanuli Regency.
Hacia la humanización de la atención de niños en hospitales
Authors: Serradas Marian
Published: August 2022

Existe evidencia científica de que el medio físico en que se prestan los cuidados sanitarios tiene un impacto en la salud y bienestar de los pacientes. Esta evidencia y la necesidad de cumplir con estándares en la atención de la infancia hacen que cada vez seamos más conscientes de la importancia que tienen para la calidad de vida del paciente pediátrico, los factores organizativos y físicos del entorno hospitalario. En tal sentido, este trabajo se centró en la revisión de algunas consideraciones sobre la humanización en el contexto hospitalario, así como algunas medidas adaptadas a las características del niño hospitalizado.
Problems of rational use of agricultural lands in Ukraine
Authors: Kirichenko Kseniia
Published: August 2022

The article examines the problem of rational land use in Ukraine. It was established that, in comparison with European countries, the level of soil plowing in Ukraine is very high and does not meet the norms of rational land use. The author determined that the violation of scientifically based norms for the use of land resources leads to a significant decrease in soil fertility, as well as to significant destructive ecological consequences. It is characterized that the development of large agricultural holdings, which are focused on the cultivation of highly profitable agricultural crops, does not contribute to the development of competition in the agricultural sector, violates the norms of crop rotation in agriculture. The main tools that will contribute to the formation of optimal dimensions and the effective use of resource potential in the conditions of globalization have been determined, namely: the introduction of a system of planning and budgeting of production processes; alternation of cultures; the use of GPS-mapping of land with an indication of crop history, land quality and cultivation technology. The author proposed the main directions of rational use of land use, which are based on the development and implementation of national and regional programs for land protection and reproduction of soil fertility, the introduction of scientifically based crop rotations, and the formation and improvement of the regulatory and legal framework.
Entrepreneurship Education Analysis and Planned Behavior Theory in Triggering Entrepreneurial Intentions Among Students
Authors: Handiman Unang Toto , Wardhani Shita Lusi , Sutawijaya Ahmad Hidayat , Affini Dinar Nur
Published: August 2022

The purpose of this study was to analyze the Planned Behavior Theory and entrepreneurship education in triggering students' entrepreneurial intentions. This research was conducted at Mercu Buana University. The respondents of this study were students of the Faculty of Economics and Business, with a total sample of 250 student respondents. This study uses quantitative methods. The data collection technique used the snowball technique. Data processing uses a statistical model of Structural Equation Modeling-Partial Least Square (SEM-PLS) with the help of SMART PLS software. The study found that Entrepreneurship education has a significant influence on Attitude Toward Behavior, Subjective Norms, Perceived Behavioral Control and entrepreneurial intentions. Attitude Toward Behavior has a a significant effect on entrepreneurial intentions. Subjective Norms and Perceived Behavioral Control has no significant effect on entrepreneurial intention. Entrepreneurship education with Attitude Toward Behavior, Subjective Norms and Perceived Behavioral Control simultaneously has a moderate influence on entrepreneurial intentions.
Regulatory Technology (RegTech): The Solution to Prevent Money Laundering in Indonesia
Authors: Utami Alivia Meyrizka , Septivani Mega Dwi
Published: August 2022

Since the 2008 financial crisis, the complexity of regulations and the use of technology and innovation in the financial sector have increased. This makes banks as financial institutions starting to adapt to financial technology very vulnerable to technological risks, one of which is money laundering. Regulatory Technology (RegTech) is a technology trend to assist bank management in supporting regulatory compliance efforts and offering money laundering prevention solutions. Based on this, this study aims to examine the relationship of RegTech, which is represented by three independent variables: Electronic Know Your Customer (e-KYC), Transaction Monitoring, and Time and Cost Efficiency, on Money Laundering Prevention. This study shows that transaction monitoring, as well as cost and time efficiency, have a significant effect on money laundering prevention. In contrast, e-KYC does not affect money laundering prevention. This research is intended to provide valuable insights to Financial Institutions to increase awareness of the importance of adopting new technologies and maintaining good relations with regulators to prevent money laundering in Indonesia.
INCIDENCE OF TINEA INCOGNITO IN PATIENTS WITH DERMATOPHYTOSIS
Authors: Sharada R.G. , A Thillaikkarasi
Published: August 2022

BACKGROUND: Dermatophytosis is a common supercial fungal infection of the skin.In India there is casual and indiscriminate use of over- the-counter topical medications.Topical steroids are the most widely used agents and inappropriate use of these agents lead to side effects. ToAIM: assess the magnitude of topical corticosteroids use in dermatophytosis by studying the source of medication, demographic variables, and side effects. It is a cross sectional, questionnaire based study carried out in the Department of Dermatology,MATERIALS AND METHODS: Venereology and Leprosy,Saveetha medical college. One hundred patients conrmed to have Tinea incognito were questioned about the duration of illness, the medications used and the side effects observed. An informed consent will be obtained from all the patients and recorded on specialized designed proforma. The study population consisted of 74 males and 26 females.Tinea corporis is the most common patternRESULTS: observed(53%).Clobetasol was the common drug misused and 75% of the study population complained of adverse effects. CONCLUSION: Topical corticosteroids are constantly being used for indications where they shouldn't be used.The increasing threat of OTC(Over the counter) use is evident from this study .Thus better control policies and awareness of side effects is the need of the hour.
A 5 YEAR PROSPECTIVE COMPARATIVE STUDY OF ENDOSCOPIC VERSUS MICROSCOPIC TYMPANOPLASTY IN A TERTIARY CARE CENTRE OF SOUTH INDIA.
Authors: Manimaran Vinoth , Joseph Kennedy Richard , Lakshmanan Somu , asu Palanisamy Thirunavukkar
Published: August 2022

CONTEXT: Type 1 tympanoplasty is one of the commonest performed surgeries by otolaryngologists across the world. Endoscopic ear surgeries
(EES) are gaining more popularity in recent times. The objective of this study is to evaluate the outcomes of endoscopic type 1AIMS:
tympanoplasty and compare with that of microscopic tympanoplasty A prospective observational comparative studySETTINGS AND DESIGN:
of two surgical techniques was conducted in a tertiary care hospital of south India from 2015- 2019. All patientsMETHODS AND MATERIAL:
underwent type 1 tympanoplasty either endoscopic or microscopic using temporalis fascia graft. S StatisticalTATISTICAL ANALYSIS USED:
package for the social sciences (SPSS) version 17 was used to analyse the data. Chi square test/Fisher's exact test was used to analyse the qualitative
data. Student t test was used to analyse the quantitative data A total of 152 patients who satised the study criteria were included in this. RESULTS:
study. 80 patients underwent endoscopic tympanoplasty (Group A), while 72 patients microscopic tympanoplasty (Group B). Both the groups were
comparable with respect to age gender, size and location of perforation. The mean operative time for group A and group B were 45.3 ± 7.1 and 50.2±
8.1 mins respectively (P=0.01). Successful graft uptake was observed in 75/80(93.75%) and 68/72(94.4%) in group A and group B (P= 0.45). Mean
pre and post operative ABG were 30.2 ± 3.2 dB &29.8± 3.6 dB and 11.6± 1.8 dB & 11.9± 2 dB respectively (p= 0.32 and P=0.24). Group A had
better post-operative VAS scores(P=0.01) and lesser canalplasty requirement(p=0.04) In this study, the hearing results ofCONCLUSIONS:
endoscopic and microscopic tympanoplasty were comparable and no signicant difference was observed. However, endoscopic tympanoplasty
had better outcomes in terms of lesser canalplasty requirement and post operative pain scores.
A COMPARATIVE STUDY OF STAPLERS VERSUS HAND SEWN ANASTOMOSIS IN INTESTINAL SURGERIES
Authors: Parmar Uvaish , Anchalia Manjulata , Desai Chirag , Khiria Lakshman
Published: August 2022

INTRODUCTION: Intestinal anastomosis is a surgical procedure to establish communication between two separated portions of the intestine. This procedure restores intestinal continuity after removal of a pathological condition affecting the bowel. Intestinal anastomosis can be performed by a hand-sewn technique using absorbable or non-absorbable sutures, mechanical stapling devices. Sutured anastomosis (hand-sewn technique) is the commonly used method. The newer stapling devices for intestinal anastomosis has provided an alternative option to perform rapid anastomosis.1 Various studies have contradictory results in terms of duration of procedure, post operative recovery and anastomotic leak. There are insufcient evidence to demonstrate superiority of either technique and more studies are needed to demonstrate the superiority of either technique. AIM MATERIAL AND METHODS:: To study and compare the effectiveness of staplers vs hand sewn anastomosis in Intestinal surgeries. A comparative observational study Consists of patients presenting with need of bowel resection and anastomosis inclusion criteria at Apollo Hospital Gandhinagar, Gujarat. The patients who are admitted for elective as well as emergency resection & anastomosis of small and large intestines for various illnesses are selected after thorough clinical examination and investigations to conrm the diagnosis co- morbid conditions. Details were recorded in the proforma prepared. : 62.5% complications in comorbid subjects and 37.5% complications in non comorbid subjects.RESULTS The mean of anastomotic time for hand sewn group was 27.8 minutes whereas for the stapler group it was 9.0 minutes mins .With respect to return of bowel sounds, mean time was 46.32 hours in the hand sewn group and 35 hours in the stapler group Mean day of hospitalization was 8.16 days in hand sewn and 7.8 days in stapler technique. mean time taken for resumption of oral feeds the was 66.96 hours in hand sewn group and was 59.52 hours in stapler group .hand sewn group had total ve complications(20%), whereas stapler group had three complications(12%) Both the groups did not have any mortality. The mean cost of hand sewn anastomosis is 717.4 Rs which is signicantly less than mean cost of stapled anastomosis which is 33,754 Rs. : Stapler anastomosis signicantly reduces operative time and time taken for return of normal bowel sounds.CONCLUSION Because of the shortened total operating time in the stapled anastomosis .There is increased risk of overall complications in patients having co- morbidities in both hand sewn and stapled anastomosis. Mechanical staplers are far more costly than suture materials. Stapling technique can be used safely and effectively
PHARMACOEPIDEMIOLOGY OF DRUGS UTILIZED IN SKIN OUTPATIENT DEPARTMENT OF A TERTIARY CARE HOSPITAL
Authors: Khanna Malav Puja , Saini Savita , Singh Arti
Published: August 2022

Periodical auditing of drug utilization is vital for the purpose of promoting rational use of drugs. So, for pharmacoepidemiological analysis of the
drugs, used in skin OPD, a study was held prospectively for 3 months, in the department of Skin and Pharmacology. Data were collected from
prescription form of the patients in OPD. Various parameters of utilization pattern was evaluated. The maximum number of patients belonged to
age group of ---------years and lower middle class of socioeconomic status but there was no sex preponderance. Dosage, duration and frequency of
therapy was recorded in more than 89% of prescriptions. the average number of drugs per prescription were 2.69 ; drugs prescribed with their
generic names were 26.04% ; xed dose combinations prescribed were 36.98% and polypharmacy found were 23.3% of prescription in the OPD.
The commonest dosage form were -----------. More than 80% of drugs were prescribed from hospital pharmacy. Average total cost per prescription
was ---------INR in OPD; but was free of cost from hospital pharmacy.
CURRENT CONCEPTS AND RECENT ADVANCES IN PERI-IMPLANT DISEASES: - A NARRATIVE REVIEW.
Authors: Siddiqui Humaira , Patra Laxmikanta , Chandra Raj Subash , Tabassum Shaheda , Mishra Asit Kumar , Srivani Peri , Sil Swoyangprava , Pattanaik Abinash
Published: August 2022

The insertion of the dental implant in order to replace missing teeth in partially and completely edentulous patients is a successful treatment
modality for over 50 years now. However, its predictability and applicability for a variety of treatment options is still a clinical dilemma. Peri-
implantitis represents a serious condition after implant therapy and affects both hard and soft tissues surrounding an implant. While implant therapy
represents a safe treatment option with high long-term success, reported complications are associated with improper treatment planning, surgical
and prosthetic replacement, material failure and maintenance. Peri-implant lesions may develop after several years of implant placement therefore
regular check-ups and life-long supportive periodontal therapy is a must. The management protocol for peri-implant diseases consists of various
conservative and surgical approaches. Peri-implant mucositis and moderate peri-implant lesions can be treated with a conservative approach using
non-surgical therapy and local and systemic antibiotics. Resective and regenerative therapy are advocated for more severe lesions to completely
eliminate the disease. However, due to the lack of prospective randomized long-term follow-up studies, no ideal implant therapy can be implicated.
The aim of this review is to provide an overview of current data and to suggest different treatment modalities for diagnosis, prevention and
management of peri-implant diseases.
DISTAL RENAL TUBULAR ACIDOSIS WITH SEVERE HYPOKALEMIA – A CASE REPORT
Authors: Chatterjee Shruti Shree , Barman Moumita , Mukhopadhyay Adittayan , Charan Pal Abhay
Published: August 2022

Background: Renal tubular acidosis is a group of transport defects secondary to either reduced distal secretion of hydrogen ion or decreased
proximal tubular reabsorption of bicarbonate or both, resulting in impaired acidication of urine with persistent hyperchloremic metabolic
acidosis. Our case is that of a 5-year-old female child presenting with failure to thrive and weakness.Clinical description and Investigations:
Physical examination revealed skeletal deformities with enamel defects. Subsequent blood tests and arterial blood gas analysis revealed
hyperchloremic metabolic acidosis with hypokalemia. Urine analysis revealed a positive urinary anion gap with hypercalciuria and hypocitraturia.
Imaging studies revealed skeletal changes secondary to rickets and USG whole abdomen showed bilateral kidney nephrocalcinosis. Oral
ammonium chloride loading was given and blood and urine pH were monitored every hour for the next 6 hours but the urine pH failed to fall below
5.3 which led us to a diagnosis of distal renal tubular acidosis. Bicarbonate and potassium citrate supplementation was given alongTreatment:
with vitamin D and calcium to this child. Timely diagnosis and initiation of appropriate supplementation can help in improving theConclusion:
quality of life of these patients.
IMMUNOHISTOCHEMICAL STUDY OF DESMIN, EPITHELIAL MEMBRANE ANTIGEN AND CALRETININ IN PLEURAL FLUID CELL BLOCK PREPARATIONS
Authors: Ningthoujam Jaya , Laisom Alpana , Devi Kh. Ambala
Published: August 2022

Background: Distinction between reactive mesothelial cells, malignant mesothelioma and carcinoma is challenging in both biopsy and cytologic
material. This study was conducted to differentiate benign/ reactive mesothelial proliferation from malignant mesothelial proliferations and
metastatic adenocarcinoma by using immunohistochemical (IHC) markers Desmin (DES), Epithelial membrane antigen (EMA) and Calretinin
(CAL) in pleural uid cell block (CB) preparations. A two year descriptive study (Oct.2016- Sept.2018). 46 pleural uids samples sentMethods :
to the Dept. of Pathology, RIMS for routine examination and histopathological examination by CB preparation were studied using IHC markers
EMA,DES and CAL following H & E stain. Out of 46 cases, 9(19.6%) cases were diagnosed as benign, 23(50.0%) as reactive andResults:
14(30.4%) as adenocarcinoma on H & E section by CB preparations within an age range 34 to 80 years (Mean±SE, 60.32±12.13). Following IHC
staining with EMA, DES & CAL, 11(23.9%) cases were conrmed as benign, 17(37.0%) as reactive, 16(34.8%) as adenocarcinoma and 2(4.3%)
cases as malignant mesothelioma. This study showed that EMA, DES and CAL helpful in conrming benign or reactive mesothelialConclusions:
and malignant mesothelial with epithelial cells which will be helpful in providing appropriate diagnosis in difcult cases and provide better
patient management.
AN EPIDEMIOLOGICAL STUDY ON HYPERTENSION AMONG SCHOOL GOING
ADOLESCENT IN URBAN AREA OF PATNA, BIHAR
Authors: Kumar Vikash , Ranjan Bharati Dharmvir , Prasad Nidhi , Kumar Sanjay
Published: August 2022

INTRODUCTION: Hypertension or high blood pressure is one of the major non-communicable health problems of 21st century associated high
morbidity and mortality, global burden of which increasing day by day. Hypertension is a key risk factor for cardiovascular diseases which affects
people silently all over the world. It is suggested that hypertension has its origin in childhood but goes undetected unless specically looked for
during this period. Thus early detection of hypertension and its precipitating or aggravating factors are important if one is to evolve measures so that
complications of hypertension can be averted. To estimate prevalence of Hypertension among Adolescent school students, to studyObjectives:
distribution of blood pressure of adolescent school students according to age, sex and height and to identify the socio demographic and behavioral
factors associated with Hypertension among school students. This was School based, epidemiological, observational Study wasMethods:
conducted in two Government co-education secondary and higher secondary (H.S) schools in urban area of Patna Bihar. In Female Group,Result:
15(8.2%) students had SBP <90 mm Hg, 127(69.4%) school students had 91-119 mm Hg systolic blood pressure, 37(20.2%) school students had
120-129 mm Hg systolic blood pressure. In Male Group, 36(17.6%) students had SBP of <90 mm Hg, 93(45.6%) students had 91-119 mm Hg
systolic blood pressure, 35.8%school students had SBP between 120-129mm Hg and SBP 2 male students was 130 mm Hg or more. In Female
Group, DBP of 156(85.2%) students were between 51-79 mm Hg, and 27(14.8%) students had DBP of ≥80 mm Hg. In Male Group, 10(4.9%)
students had DBP of ≤50mm Hg, 178(87.3%) students had 51-79mm Hg of Diastolic blood pressure and 16(7.8%) school students had ≥80mm Hg
DBP. Findings of the study is expected to be of much help to the public health programme planner and manages to ne tune strategicConclusion:
intervention for reducing non-communicable disease burden in the country.
The Concentration of Heavy Metals in the Sediments of the River Nun Estuary, Around Akassa, Niger Delta, Nigeria
Authors: H Gijo, A. , J Alagoa, K.
Published: August 2022

Levels of the heavy metals lead (Pb), cadmium (Cd), nickel (Ni), zinc (Zn), and manganese (Mn) were analyzed in the sediments of the River Nun estuary. This was done in order gauge the impact of anthropogenic inputs such as pesticides, fertilizers, oil spillage and other industrial and anthropogenic wastes disposal, especially at the coastal parts of the region on bottom sediments. Three sampling Stations were chosen for the purpose of this research. Station 1 (Buo-Ama Creek) was established close to the entrance of Buo-Ama creek, in the Nun River estuary. Station 2 (Erewei- Kongho) was established along one of the tributaries of the Nun River estuary around Erewei- Kongho. Station 3 was established in Ogbokiri. Sediment samples were collected with the aid of a soil auger and a galvanized metal core cylinder from the three (3) sampling stations along a transect running from the low intertidal level (LIL), through the mid intertidal level (MIL) to the high intertidal level (HIL). Sediment samples were analysed in the laboratory using the method of Atomic Absorption Spectrophotometer (AAS). Means and standard deviations were calculated for all the measured parameters. A one-way ANOVA was employed at the 95% confidence limit to test for differences across stations in the heavy metals. Turkey HSD post HOC test was also employed to separate means and identify where variability and similarities exist. This was aided by the SPSS 20.0 statistical tool kit. The result shows that Pb has the highest concentration, followed by Zn, Ni, Cd, and Mn respectively. The lowest values of all metals were observed at station 2, while the highest concentrations of metals were recorded at sampling stations 1. The results show that the value of Pb was highest in station 1(1.347±0.001), followed by Station 3 (1.24±0.001). Station 2 had the least mean value of Pb (0.884±0.001). Cd showed similar patterns across the three sampling stations 1, 2 and 3, with the values 0.068±0.002, 0.046±0.001, and 0.054±0.002 respectively. Ni also presented slight difference across the three sampling stations. Concentration of Zn were higher in station 1 and 2 (1.265±0.002 and 1.038±0.002), than in station 3 (0.725±0.001). All metal concentration was however lower than the international permissible limited. The concentrations of Mn were also observed to present a similar pattern across the sampling stations. There is a significant difference (P<0.05) in all heavy metal parameters across all stations. Heavy Metal Concentrations were found to decrease with increasing distance from the river mouth, suggesting that anthropogenic inputs, related to agricultural and domestic discharge into the river, are the major sources of heavy metals in the river sediments. Land based activities therefore have a profound effect on aquatic ecosystem stability and health.
Incorporação das TDIC nas práticas pedagógicas de professores de Ciências e Matemática da Educação Profissional Técnica de Nível Médio
Authors: Machado Silvia Cota , Ramos Ivo De Jesus , Ortega Leila Saddi
Published: August 2022

Esta pesquisa buscou compreender as percepções dos professores de Ciências e Matemática da Educação Básica Técnica e Tecnológica (EBTT) sobre a incorporação dos recursos das Tecnologias Digitais da Informação e Comunicação (TDIC) nas práticas pedagógicas para mediar os processos de ensino e de aprendizagem e quais as potencialidades e/ou limitações desses recursos. A metodologia segue abordagem qualitativa do tipo exploratória. O questionário online foi aplicado a 23 professores. Os resultados sinalizam que os professores da EBTT participaram de cursos de capacitação para mediar as atividades de ensino no Ensino Remoto Emergencial (ERE). Constatou-se que, em relação ao ERE, a maioria percebe que as experiências com as TDIC para mediar o ensino foram positivas. Os professores experienciaram novas possibilidades e consideram que, por ser uma experiência nova necessita de avaliação contínua e periódica para aprimoramento e adaptações. Os relatos demonstram que os professores gostariam de continuar utilizando os recursos. Entre as limitações, apontaram a falta de tempo para se capacitarem devido à carga horária de trabalho, necessidade de mais investimento em capacitação, condições socioeconômicas dos envolvidos e infraestrutura adequada por parte da instituição. Conclui-se que, mesmo diante das dificuldades, os professores buscam se atualizar e reconhecem a importância da inclusão digital.
Feiras de ciências durante a pandemia de COVID-19: um estudo sobre eventos on-line
Authors: Santos Adevailton Bernardo Dos , Santos Luan Rafael Pereira , Avelar Samara Oliveira
Published: August 2022

As feiras de ciências são eventos relacionados a apresentação de trabalhos de pesquisa desenvolvidos na educação básica, podendo ser implementadas como atividade de extensão universitária e associadas a atividades de divulgação científica. Devido as medidas de distanciamento social para a contenção da pandemia de COVID-19 e realização virtual dos eventos científicos, este texto relata uma pesquisa que buscou traçar um comparativo entre eventos virtuais de feiras de ciências com os presenciais. Um questionário on-line foi respondido por dez orientadores de trabalhos apresentados na feira Ciência Viva de 2020 e os resultados indicaram que o modelo de realização presencial é o preferido, principalmente pela possibilidade de maior interação entre os participantes e com a comissão avaliadora. No entanto, apesar de alguns problemas, principalmente quanto a dificuldade de apresentação e de estabilidade na conexão à internet, o modelo de realização virtual foi apontado como um facilitador para a participação de pessoas que residem fora da área de abrangência do evento. Os organizadores e participantes de eventos científicos devem se atentar para o fato do modelo virtual passar a ser utilizado com mais frequência, buscando formas de aproveitar esta nova situação de modo mais eficiente.
Uso de simulações computacionais em aulas de Física: uma Revisão Sistemática de Literatura (RSL)
Authors: Silva Cristiana Maria Dos Santos , Romeu Mairton Cavalcante , Barroso Maria Cleide Da Silva
Published: August 2022

Este artigo tem como objetivo compreender as potencialidades da utilização de simulações computacionais, descrevendo características apontadas a partir da análise de produções científicas que despertem o interesse do aluno e facilite o processo de aprendizagem no ensino de Física. Para tanto, foi utilizada uma metodologia fundamentada em uma Revisão Sistemática de Literatura (RSL), com abordagem qualitativa descritiva, a partir da leitura e consultas em artigos, dissertações e trabalhos publicados em anais de congressos. A coleta de dados foi realizada através do Portal Periódicos da CAPES e Google Acadêmico. O período de busca foi de 2015 a 2021. Para filtrar as pesquisas, foram utilizadas palavras-chave como: “Simulações computacionais - Ensino de Física” (145); “ Simulações computacionais “PhET - Ensino de Física” (05) e “Tinkercad - Ensino de Física” (47). Foi possível identificar 197 trabalhos iniciais, somente 19 representaram uma amostra significativa, porém apenas 10 publicações objetivaram mapear as intenções pedagógicas da pesquisa com trabalhos publicados dos últimos cinco anos. Conclui-se que as simulações virtuais podem ser uma alternativa para respeitar o ritmo de aprendizagem dos alunos, permitindo que estes consigam um feedback rápido e que possam avançar no processo de aprendizagem de acordo com o desenvolvimento das suas competências e habilidades.
Escola Cidadã Integral: Percepções de Professores do Ensino Médio sobre a Prática da Tutoria
Authors: De Luna Leossandra Cabral , Dantas Filho Francisco Ferreira
Published: August 2022

A evasão escolar e os baixos índices nas avaliações de larga escala são dois dos maiores problemas da Educação Básica brasileira, sobretudo no Ensino Médio. Nesse contexto, o Governo da Paraíba adotou o modelo da Escola da Escolha, com vistas a melhorar a qualidade do ensino ofertado. Uma das especificidades do modelo é a pedagogia da presença, na qual destacamos a tutoria, uma prática educativa na qual os docentes acompanham os estudantes mais de perto. Nesse sentido, esta pesquisa buscou identificar as concepções e práticas do professores-tutores no contexto de uma Escola Cidadã Integral do Estado da Paraíba.  Para tanto, foi realizada uma pesquisa qualitativa e exploratória. O estudo de caso contou com a participação de dezoito professores que responderam a um questionário online contendo dez questões das quais seis eram abertas e quatro eram fechadas. Com os dados obtidos foi possível entender como eram as práticas dos docentes e suas principais dificuldades. As falas dos professores nos levaram a observação da semelhança da tutoria com a Orientação Educacional, sendo necessário rever as especificidades do modelo integral, as condições de  trabalho dos docentes, bem como a valorização e a presença de orientadores educacionais nas escolas.
Proposta de uma Tabela Periódica adaptada com vistas à acessibilidade de estudantes com deficiência visual: um recurso didático para o ensino inclusivo
Authors: Da Silva Graziele Del Sent , Stadler João Paulo
Published: August 2022

Este trabalho tem por objetivo apresentar o desenvolvimento de uma proposta de adaptação da tabela periódica para estudantes com deficiência visual. Na primeira etapa da pesquisa, foi realizada uma revisão sistemática de literatura, na qual buscou-se, em anais dos eventos ENPEC e ENEQ, artigos que fossem relacionados à confecção da Tabela Periódica adaptada para esses estudantes, encontrando um total de nove artigos. Foram analisadas as limitações e potencialidades desses materiais, para que, então, fosse elaborado o material adaptado descrito no artigo, seguindo as especificações da NBR 9050. Primeiramente, foi realizada a confecção de uma tabela em acrílico com marcação em laser e escrita em Braille no formato da Tabela Periódica, mantendo o menor tamanho possível, de modo a superar uma das limitações dos modelos analisados. Como material auxiliar, foram criadas placas em Braille de cada elemento químico que complementa as informações omitidas em virtude da redução do tamanho da tabela produzida. Espera-se contribuir com a análise das características dos materiais adaptados e que o recurso aqui apresentado possa superar as limitações encontradas para que complemente o estudo da classificação periódica dos elementos e, em maior âmbito, para a inclusão dos alunos com deficiência visual.
Gobernanza educativa desde la política pública hasta el aula de clase en una perspectiva crítica y emancipatoria
Authors: Ramirez Jacqueline , Zanon Lenir Basso
Published: August 2022

En este articulo son discutidos sentidos atribuidos a la finalidad educativa del estudio en la escuela, entendiendo que su especificidad hace parte de una compleja red de relaciones en la cual las políticas públicas y los procesos de gobernanza educacional hacen parte.   Se trata de un estudio de carácter analítico descriptivo, organizado como un ensayo teórico sobre el tema de gobernanza en el ámbito de la educación, con atención orientada para una perspectiva crítica y emancipatoria. Es asumido un concepto de gobernanza educativa que articula la relación de interfase entre el escenario general de las redes de políticas públicas y el contexto local de cada escuela, vinculado con realidades problemáticas de vulnerabilidad social a ser resignificadas en las prácticas en el aula, en medio de la actual reforma curricular en Brasil. Resultados señalan la importancia de avanzar en el estudio y construcción de una gobernanza educativa critica, reflexiva y libertadora, contextualizada tanto en las redes de políticas públicas, como en las prácticas en condiciones pedagógicas reales, que contribuya en la consecución de una educación propulsora de la integralidad del desarrollo social civilizatorio, esencia y finalidad en la escuela humanizadora de la vida en sociedad.