bluuebunny/crossref_metadata_2025 huggingface dataset:
Study on the zinc porphyrins as potential carbonic anhydrase mimics for promoting CO2 absorption in K2CO3 solution
Authors: Chen Zezhi , Zhou Yuchen , Gong Huijuan , Wang Xiaoshu , Chen Lu , Yu Huiqiang
Published: November 2023

Zinc porphyrins, boasting a coordination environment akin to that of carbonic anhydrase (CA), coupled with excellent structural stability, built-in hydrophobic pocket, and relatively low charge of center Zn2+, offer promise as CA-mimics for industrial CO2 capture. In validation, three representative zinc porphyrins—zinc porphin (ZnP), zinc protoporphyrin IX (ZnPP), and zinc meso-tetrakis(N-methylpyridinium-4-yl) porphyrin (ZnTMPyP) were synthesized and tested performance in water and 2 wt.% K2CO3 solution. Results showed that zinc porphyrins enhanced CO2 absorption by up to 44.25% in water and 46.77% in K2CO3 solution, which surpassed zinc cyclen (ZnC), one of the most efficient CA-mimics reported, by 1.31-1.53 times even at significantly lower dosages. Besides, they demonstrated excellent stability and reusability. Calorimetry and density functional theory (DFT) confirm their CA-mimetic activity and CA-like CO2 hydration pathway. High dispersion, lowest Zn2+ charge, and abundant CO2 adsorption sites endow ZnPP with the highest catalytic activity in K2CO3 solution.
Unlocking the potential of ultra-high dose fractionated radiation for effective treatment of glioblastoma
Authors: Lan Xiao-Yan , Kalkowski Lukasz , Chu Cheng-Yan , Jablonska Anna , Li Shen , Kai Mihoko , Gao Yue , Janowski Miroslaw , Walczak Piotr
Published: November 2023

Background: Conventional radiation therapy for glioblastoma (GBM) has limited efficacy. Regenerative medicine brings hope for repairing damaged tissue, opening opportunities for elevating the maximum acceptable radiation dose. In this study, we explored the effect of ultra-high dose fractionated radiation on brain injury and tumor responses in immunocompetent mice. We also evaluated the role of the HIF-1α under radiation.
Methods: Naïve and hypoxia-inducible factor-1 alpha (HIF-1α)+/- heterozygous mice received a fractionated daily dose of 20 Gy for three or five consecutive days. Magnetic resonance imaging (MRI) and histology were performed to assess brain injury post-radiation. The 2×105 human GBM1 luciferase-expressing cells were transplanted with tolerance induction protocol. Fractionated radiotherapy was performed during the exponential phase of tumor growth. BLI, MRI, and immunohistochemistry staining were performed to evaluate tumor growth dynamics and radiotherapy responses. Additionally, animal lifespan was recorded.
Results: Fractionated radiation of 5×20 Gy induced severe brain damage, starting 3 weeks after radiation. All animals from this group died within 12 weeks. In contrast, later onset and less severe brain injury were observed starting 12 weeks after radiation of 3×20 Gy. It resulted in complete GBM eradication and survival of all treated animals. Furthermore, HIF-1α+/- mice exhibited more obvious vascular damage 63 weeks after fractionated radiation of 3×20 Gy.
Conclusion: Ultra-high dose fractionated 3×20 Gy radiation can eradicate the GBM cells at the cost of only mild brain injury. The HIF-1α gene is a promising target for ameliorating vascular impairment post-radiation, encouraging the implementation of neurorestorative strategies.
Risk factor analysis of changes in blood flow in the A1 segment of the anterior cerebral artery after FD coverage of it
Authors: Ma WuLin , Xin Deng , Chen JunFan , Guo XinBin
Published: November 2023

BackgroundFew studies have explored the effect of flow diverter device (FD) on blood flow in A1 segment of the anterior cerebral artery (ACA), after treatment of intracranial aneurysms in the bifurcation region of the internal carotid artery (ICA). The main objective of this article is to investigate the factors that affecting A1 blood flow after FD cover the A1 artery.Materials and MethodThis is a single-center, retrospective study. Data were collected retrospectively from our center, patients whose FDs were placed for treatment from the terminal of the ICA to the M1 segment were analyzed.ResultsA total of 42 patients were included in the study. Immediate post-procedural angiography following device placement revealed decreased blood flow in the A1 of 15 (35.7%) patients and complete occlusion of the A1 segment in 11 (26.2%) patients. During an average follow-up period of 9.8 months, the A1 segment was ultimately occluded in 25 patients (59.5%), decreased blood flow in 4 patients (9.5%).ConclusionWhen using FD to cover the A1 artery for the treatment of intracranial aneurysms, patients with preoperative opening of the anterior communicating artery (AcomA) are more prone to occlusion or decreased blood flow of the A1 artery, compared to patients without opening.
Causal relationships between gut microbrome and digestive system diseases: a two-sample Mendelian Randomization study
Authors: Ding Wenjing , Chen Liangliang , Xia Jianguo , Dong Gang , Song Biao , Pei Bei , Li Xuejun
Published: November 2023

Background
Growing evidences of recent studies have shown that gut microbrome is causally related to digestive system diseases. However, causal relationships between the gut microbiota and the risk of digestive system diseases still remain unclear.
Methods
We utilized identified gut microbiota based on class, family, genus, order and phylum information and digestive system diseases (DSDs) GWAS dataset for two-sample Mendelian randomization (MR) analysis. The inverse variance weighted (IVW) method was used to evaluate causal relationships between gut microbiota and seven DSDs. Finally, we verified the robustness of MR results based on heterogeneity and pleiotropy analysis.
Results
We discovered 15 causal associations with genetic liabilities in the gut microbiota and DSDs, such as genus Victivallis, genus RuminococcaceaeUCG005, genus Ruminococcusgauvreauiigroup, genus Oxalobacter and so on.
Conclusions
Our MR analysis revealed that the gut microbiota is causally associated with DSDs. Further researches of the gut microbiota and the pathogenesis of DSDs are still significant and provide new methods for the prevention and treatment of DSD.
Symptom Burden Survey and Symptom Clusters in Chemotherapy Period of Lung Cancer
Authors: 王 妍 , Fang Liyuan , Zhou Kainan , Xie Yi , Yang shuhan , Liu Suying , Fang yuhang , Wang runxi , Sui Bailu , Zhang Ying
Published: November 2023

Purpose
The objective of the study was to research the symptom burden and symptom distribution characteristic of lung cancer patients during chemotherapy, identify the symptom clusters (SCs) and explore the mechanism of lung cancer specific SC, so as to provide evidence for clinical staff to manage symptoms and SCs.
Methods
All participants were recruited at the inpatient Oncology Department of Guang 'anmen Hospital, China Academy of Chinese Medical Sciences between July 2022 to December 2022. Investigate the incidence and severity of symptoms of lung cancer patients during chemotherapy. Exploratory factor analysis was used to identifySCs. SCs were identified for the mild, moderate and severe symptoms and for the moderate and severe symptoms respectively. Spearmen correlation analysis was used to analyze the correlation between lung cancer specific SC and blood routine index.
Results
A total of 169 patients participated in the study. The study found that, among the 43 symptoms, the most prevalent and the most serious symptoms was loss appetite. Based on the occurrence rate and severity of symptoms, SC extraction was performed for mild, moderate and severe symptoms with a symptom incidence more than 20%, and five SCs were identified, including psycho–emotion SC, chemotherapy related SC, lung cancer specific SC, urinary related SC, and gastrointestinal SC. For moderate and severe symptoms, two SCs were identified, including chemotherapy related SC and lung cancer specific SC and the lung cancer specific SC was negative correlation with eosinophils.
Conclusion
Patients with lung cancer during chemotherapy have complex and diverse symptoms. Based on different SC extraction methods, five SCs and two SCs were identified respectively. At the same time, the study explored the potential biological mechanism of lung cancer specific SC, and it was showed that lung cancer specific SC was related to eosinophils negatively. In the future, more research should be done on the research tools, research methods, pathogenesis and intervention measures of SCs.
Identification of Cervical Disc Degeneration and Genes Associated with Immune Infiltration
Authors: Bei Dikai , Chen Binhui , Zhao Fengdong , li Jie , Gan Kaifeng
Published: November 2023

Objective: This study aims to identify new diagnostic genetic-biomarkers for early-stage cervical intervertebral disc degeneration (IDD) and analyze the potential association between key genes and infiltrating immune cells.
Methods: Cervical disc specimens were collected from anterior cervical discectomy and fusion surgery, which were classified into IDD and controlled group depending on MRI disc degeneration grade. mRNA expression profile data was downloaded from the GEO database. Differentially expressed genes (DEGs) were determined from GEO database profile. Gene ontology (GO) functional annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathway enrichment analysis were performed on DEGs. LASSO regression model and Support Vector Machine Recursive Feature Elimination (SVM-RFE) algorithm were employed to screen for potential biomarkers. The composition of 22 immune cell fractions in IDD patients was analyzed using CIBERSORT. Biomarker expression levels in cervical disc specimens were detected through quantitative PCR.
Result: 71 DEGs were found, including 50 genes up-regulated and 21 genes down-regulated. KEGG pathway analysis revealed significant enrichment of inflammation-related pathways. Based on the results of two machine learning screening methods and validation in cervical disc specimens, CDKN3, SLC22A4, and SYDE1 were identified as key biomarkers for cervical IDD. Immune cell infiltration analysis showed significant differences, with higher rate of M0 macrophage and mast cell activation (P=0.004, P=0.004), and lower rate of T-cell CD8 and NK cell activation (P=0.045, P=0.024).
Conclusion: CDKN3, SLC22A4 and SYD1 are associated with the occurrence and progression of cervical IDD through the regulation of certain immune cells. Therefore, they have the potential to be the biomarkers for the diagnosis of cervical IDD and play a role in monitoring the progression of cervical IDD.
MiR-940-IL-32β-polymorphonuclear neutrophils pathway inhibits trophoblast cell invasion and induces inflammatory responses
Authors: fang Ming , chen Dan , yan Wen , jin Wen , chen Defang
Published: November 2023

The involvement of microRNA (miRNA) is of paramount importance in regulating the advancement of preeclampsia. Activating the immune system at the interface between the mother and fetus significantly contributes to the development of pre-eclampsia (PE). The activation of polymorphonuclear neutrophils (PMNs) in patients with PE necessitates additional investigation to elucidate the underlying mechanism of PMNs activation. The present work has revealed the downregulation of miR-940 expression in the plasma exosomes of individuals diagnosed with preeclampsia, which is closely related to the increased invasion of trophoblastic cells and the induction of clinical symptoms related to inflammatory responses. The upregulation of interleukin-32 (IL-32) expression is notably observed in syncytiotrophoblast cells, with interleukin-32β(IL-32β) being the primary isoform exhibiting higher expression in the placenta of individuals diagnosed with PE. In vitro investigations indicate that IL-32β exhibits a significant capacity to activate PMNs. We identified IL-32β as a direct target of miR-940 through gene expression profiling and bioinformatics analysis. Patients with low miR-940 expression, high IL-32β level, and increased PMN number had more complications and poor perinatal prognosis.
Conclusion: miR-940-IL-32β-neutrophil feedback loop inhibits trophoblast invasion and induces inflammatory response.
Food waste and its economic dimension in retail and household stage
Authors: Durmuş Hasan , Gülmez Ahmet , Naimoğlu Mustafa
Published: November 2023

Turkey is ranked in the top 10 countries that waste food worldwide, which adversely impacts the socio-economic structure, particularly considering the significant increase in food prices. The Wednesday Bazaar in Sakarya is the largest market in the Marmara region of Turkey and a critical location due to its size, regular establishment, and high participation of locals. This study investigates the amount of food waste in Sakarya province and its effect on the economy and consumption. A mixed research method, combining quantitative and qualitative techniques, was used to conduct the study. Questionnaires were distributed to households in three districts to determine demographic characteristics and food waste, while the remaining waste was classified using a waste management system. The study found that bulgur had the highest share in waste, with 13.22% among monthly food products purchased, and the most wasted products in the market were pepper, salad, tomato, and onion. The research is unique in that it is the first to observe popular bazaars frequented by households and provides insights into improving personal practices to reduce food waste, contributing to a healthier environment and financial benefits.
Unravelling Intervertebral Disc Creep behaviour through Mathematical models. An in-vitro Study
Authors: Sciortino Vincenza , Jansen Jan Ulrich , Cerniglia Donatella , Ingrassia Tommaso , Wilke Hans-Joachim
Published: November 2023

The intervertebral disc (IVD) is a complex biological structure due to its viscoelastic nature. The IVD ensures the spine strength, stability, mobility, and flexibility. This is enabled by the complex relationship between external mechanical loads and cellular response, more specifically it is related to its mechanobiology. Nevertheless, the viscoelastic properties and mechanobiology of the IVD are not fully understood. Hence, new insights are researched by investigating the IVD biomechanical response to long-term loads, which is critical since it influences hydration, nutrients, and water transport. In this paper an in-vitro study was performed on seven human lumbar spine specimens (L4-5), to assess if the classical rheological models and Nutting's power law can model the intermediate characteristics between solid and fluid of the IVD. Creep tests were conducted by applying a static compression load of 500 N for 15 minutes. A correlation analysis was done (Pearson, 𝑝 < 0.05) between the model parameters and the maximum value of Disc Height Reduction (DHR), followed by a linear regression analysis. As conclusive remarks, through this work it has been possible to underline how a mathematical modelling of the IVD long-term mechanical behaviour is of extreme importance to understand the mechanism of deformation and reduction in disc height during the day and restoration in height during the night. Future goals will be to identify the relationship between the macroscopic and cellular mechanics of the IVD, and to further understand the entire mechanism underlying disc degeneration and ageing.
Comparative Study of Solvent Effect for tryptophan Oxidation by Different Oxidants
Authors: PERIYASAMY S. K.
Published: November 2023

Quinaldinium fluorochromate (QnFC), imidazolium fluorochromate (IFC), quinoxalinium dichromate (QxDC), imidazolium chlorochromate (ICC), and quinaldinium chlorochromate (QnCC) have all performed tryptophan oxidation at 308K using various solvents, including dimethyl sulphoxide (DMSO), dimethyl formamide (DMF),acetone, dichloromethane (DCM) and 1,2-dichloroethane (DCE). This has led to the formation of the corresponding indole-3-acetaldehyde. We examined the solvent effect using the Technique for Order of Preference by Similarity to Ideal Solution(TOPSIS) method, and the solvent performance score for the reaction revealed the following order: DMSO > DMF > DCE > DCM > ACETONE. Corresponding indole-3-acetaldehyde were formed as a result of the oxidation process with all of the oxidants.
Effect of regulating Piezo2 expression in DRG on core phenotype, S1 and mPFC neuron functions in ASD mouse model
Authors: Zhai Jinhe , Hao Haiying , Xu Zihan , Tomoda Akemi , Zhang Xinyi , Wang Xinxin , Cao Xuan , Li Dongxin , Li Xiaoxue , Fan Lili , Wang Jia , Wu Lijie
Published: November 2023

Background
Tactile overreaction (TOR) in the symptoms of autism spectrum disorder (ASD) has attracted attention because of its high incidence and potential influence on the core phenotype. However, the possible causes of TOR are unclear. Piezo2 is a mechanically gated ion channel that mainly mediates low-threshold touch. But there is no research to prove whether it is related to the tactile symptoms of ASD. In this study, we investigated the expression of Piezo2 in peripheral nervous system of BTBR in ASD model mice, and whether Piezo2 inhibitor GsMTx4 can alleviate the symptoms of ASD such as TOR and social injury, and evaluated the effects on the function of neurons in primary somatosensory cortex (S1) and medial prefrontal cortex (mPFC). At the same time, we further explored whether soft touch stimulation, a non-invasive intervention method, can achieve similar effects as GsMTx4 administration.
Results
Piezo2 was overexpressed in the dorsal root ganglion (DRG) of BTBR mice than that in wild-type C57BL/6(C57) mice, accompanied by TOR of hairless skin on the sole. However, this overexpression was not found in the trigeminal ganglion (TG), and no obvious abnormal response of the face to stimulation was observed. Starting from the 28th day after BTBR was born, administration of GsMTx4 for 3 days alleviated the TOR, social deficits, and repetitive behavior in BTBR. Surprisingly, neuron overactivation in the S1 and mPFC during social activities reduced, while dendritic spine density in mPFC increased. We further found that chronic soft touch also could improve behavior and central nervous system function, accompanied by the decrease of Piezo2 overexpression in the DRG of BTBR.
Conclusion
GsMTx4 administration and soft tactile stimulation can effectively inhibit the over-expression of Piezo2 in DRG of BTBR mice, alleviate a series of ASD symptoms such as TOR and social defects, and improve the functions of S1 and mPFC cortical neurons.
The homeobox family gene signature predicts the prognosis of osteosarcoma and correlates with immune invasion
Authors: 刘 文炟 , Xia Kezhou , Huang Xinghan , Wei Zhun , Wei Zicheng , Guo Weichun
Published: November 2023

Osteosarcoma is the most common aggressive bone cancer. In recent years, it has been found that many homeobox family genes are involved in the occurrence, development, and invasion of tumors. But what role does the HOX family play in osteosarcoma remain unclear. To investigate the role of the HOX family in osteosarcoma and to develop a risk prognostic model, we collected osteosarcoma patients’ information in The Cancer Genome Atlas (TCGA) cohort. We then used LASSO regression analysis and multivariate COX regression analysis to finalize four genes (HOXA1, HOXA5, HOXA6, HOXA13) to build a risk-prognostic model. Osteosarcoma patients were divided into high- and low-risk groups. The prognosis of the low-risk group was significantly better than that of the high-risk group, and the ROC curve could well simulate the survival time of patients. We then included the age and gender of the patients to construct a nomogram, which can better predict the overall survival time of the patients. Differences in gene function between the two risk groups were more concentrated in immune-related pathways, and GSEA analysis also suggested that the immune-enrichment pathway played an important role between the two groups. ssGSEA indicated that the immune cell content and immune function in the high-risk group were relatively deficient. Finally, HOXA1 was selected for in vitro and in vivo experiments to verify. In summary, we constructed a risk prognosis model based on HOX family genes and identified HOXA1 for verification. This model has good accuracy and universality, which can improve the early diagnosis rate and predict the prognosis of osteosarcoma patients and can help clinicians make decisions and individualized treatment.
Integration von Planspielen in Hochschul-Programmen: Evaluierung der Einsatzvarianten
Authors: Huter Lucas , Pammer Maria , Pattermann Juliana , Windbichler Renate
Published: November 2023

Auf Basis von Lehrveranstaltungsevaluierungen betrachtet dieser Beitrag die Planspielmethode aus einer Bildungsmanagement-Perspektive (Meso-Ebene). Anhand von qualitativen und quantitativen Daten zu 70 Durchführungen eines betriebswirtschaftlichen Planspiels in den letzten zehn Jahren zeigen wir vier Varianten der Planspielintegration auf und analysieren dabei die Wahrnehmung der Studierenden. Die Ergebnisse zeigen, dass Planspiele unabhängig von der Integrationsvariante durchwegs positiv wahrgenommen werden. Bereits kleine Gestaltungsanpassungen von Hochschulprogrammen fördern die Berücksichtigung der Zielgruppenbedürfnisse und unterstützen dadurch das jeweilige Lernziel.
Bürokrat:innen hinterfragen Gehorsam mit dem Prinz-von-Homburg-Planspiel
Authors: Egger  de Campo Marianne
Published: November 2023

Ein eigens entwickeltes Planspiel im weiterbildenden Programm MPA (Master Public Administration) der Hochschule für Wirtschaft und Recht Berlin gab angehenden Führungskräften die Gelegenheit, ihre beruflich erworbenen Kompetenzen zu reflektieren und um ein Verhaltensrepertoire zu erweitern, das in der Bürokratie selten, aber in Zeiten populistischer Bedrohungen der Demokratie umso bedeutender ist: Sie sollten wie von Horst Bosetzky mit Bezug auf Heinrich von Kleists Drama konzipiert, wie ein Prinz von Homburg lernen, mutig Initiative zu ergreifen und sich gegen Order durchzusetzen, wenn sie dies nach sorgfältiger Prüfung ihres professionellen Gewissens für richtig hielten.
Karl Rosenkranz o mladom Hegelu u svjetlu suvremene kritike na temu
Authors: Žitko Pavao
Published: November 2023

U ovom radu problematizira se doprinos prvog Hegelova biografa cjelokupnom shvaćanju njegova opusa preko razrade i analize teza i opaski vezanih za najranije korijene njegove spekulacije u mladenačkom, odnosno predjenskom i za kritiku daleko najproblematičnijem i zasigurno najmanje poznatom razdoblju njegova filozofijskog svjetonazora i stvaralaštva. Svrha je rada ukazati, s jedne strane, na neprocjenjivu vrijednost sadržaja iznesenog ovim biografskim prikazom, kao i konzultiranog materijala na kojem se biografija temelji, a koji danas posjedujemo tek u manjkavoj fragmentiranoj formi. S druge strane, bitan dio ovdje iznesenog istraživanja sastoji se od isticanja i ispravne povijesne i kritičke kontekstualizacije određenih nekonzistentnosti i interpretativnih manjkavosti, prisutnih u ovoj prvoj ikad napisanoj biografiji o Hegelu, a koje su izvršile značajan utjecaj na sukcesivno poimanje nastanka sistema i dijalektike u kasnijoj i zreloj Hegelovoj spekulaciji.
Finding Solutions to Ecological and Environmental Crisis with a New Ethics
Authors: Pechočiaková Svitačová Eva
Published: November 2023

Ecological and environmental crises are related to the development of an anthropocentric human culture. They threaten the values on which human life and development on Earth depend, and therefore the need for a new ethic arises. The aim of this paper, which is based on a qualitative analysis of theoretical sources, is to highlight the gravity of these crises and to present a 'new ethics', which is referred to as the ethics of the future, the ethics of responsibility for the future or the ethics of sustainability. We draw on the work of H. Jonas and other thinkers who point out that the traditional ethics, which is also referred to as anthropocentric, is no longer sufficient in today's world.  It cannot contribute to solving these crises. We argue in favour of a 'new ethics' that takes into account the distant future and relies on a new dimension of responsibility, but also of justice. It urges people to be able to take responsibility for the consequences of their actions and not to endanger the survival of humanity on the planet and also of all life. With this in mind, it should also play a part in shaping their moral character.
The Synergistic Effect of Curcumin and Piperine Nanoparticles on Methamphetamine-induced Neurotoxicity, Oxidative Stress, and Memory Impairments in Mice Brain
Authors: Ebrahimnejad Pedram , Ghazvini Hamed , Hasanjani Parisa , Saberi-Hasanabadi Parisa , Akhtari Javad , Mohammadi Hamidreza
Published: November 2023

Background:

Methamphetamine (METH) is a highly addictive neural stimulant that severely affects the CNS and can induce oxidative damage. Piperine and curcumin are active constituents that have numerous properties, including antioxidant, anti-inflammatory, and neuroprotective

Objective:

In this study, the synergistic effect of piperine and curcumin nanoparticles was investigated on the acute doses of METH-induced neurotoxicity in mice brains.

Methods:

METH (6 mg/kg, i.p) was administered to 14 groups of mice and piperine-curcumin nanoparticles at different doses (10, 20, 40 mg/kg and 20, 40 and 60 mg/kg, respectively) were administered. Open field test (OFT) and conditioned place preference (CPP) were used to investigate locomotor activity, anxiety-like behavior, and addictive behavior in mice. Oxidative stress biomarkers
(reactive oxygen species (ROS), protein carbonyl content, lipid peroxidation, glutathione content,
and mitochondrial function were evaluated in isolated brain mitochondria.

Results:

We found that piperine and curcumin nanoparticles significantly decreased hyperlocomotion and anxiety-like behavior in METH-treated mice. Also, METH enhanced CPP whilst piperine
and curcumin nanoparticles suppressed the effect of METH-induced CPP. METH administration
significantly increased ROS, protein carbonyl content, and lipid peroxidation and decreased glutathione content and mitochondrial function in the isolated brain mitochondria. Piperine and curcumin
nanoparticles (at all doses) showed synergistic effects on reducing oxidative damages in a dosedependent manner compared to the METH group.

Conclusion:

In conclusion, combined piperine and curcumin nanoparticles showed greater neuroprotective effects against METH-induced neurotoxicity due to their greater permeability and better antioxidant properties than piperine and curcumin alone
An Emerging Class of Antimicrobial Heterocycles Derived from Natural Sources
Authors: Chaudhary Benu , Patial Babita , Sharma Rajiv , Chawla Anshul
Published: November 2023

:

An energetic desire to reduce the undesirable effects brought on by synthetic heterocyclic
substances and to combat antimicrobial resistance has led to an increase in curiosity in using natural
antimicrobial agents derived from plants, such as phenolics, catechol, pyrogallol, essential oils, Lchicoric acid, caffeic acid, catechins, coumarin, proanthocyanidins, 4-thiazolidinone, and alkaloids.
The usage of naturally occurring heterocycles against Gram-positive (S. aureus, S. pyogenes, B.
subtilis, A. niger, and B. cereus) and Gram-negative (P. aeruginosa, E. coli, K. pneumonia, P. vulgaris, and S. infantis) bacteria has been the subject of increased investigation in past few decades. This
review targets the use of plant-derived antimicrobials to increase the microbiological safety of food
and the possible antimicrobial activity of nitrogen- and oxygen-based heterocyclic compounds. It is
possible to find novel medications to treat infectious diseases and address the issues brought on by
antibiotic resistance by exploring and utilising the potential of these chemicals. Additional research
is desirable on the toxicological effects and potential additive and/or synergistic antimicrobial actions
in order to maximise the usage of these potential natural antimicrobials in foods.
Gut–Skin Axis: Gut Microbiota as a Link Between Rosacea and Gastrointestinal
Comorbidities
Authors: Arora Navneet , Kumar Ranjeet
Published: November 2023

Rosacea, a prevalent dermatological condition, is characterized by the clinical manifestations of erythema, papules, and pustules. This paper delves
into the emerging role of the gut-skin axis in Rosacea's pathophysiology. Convincing evidence supports the involvement of gut microbiota in
orchestrating the inflammatory cutaneous response. Its multifaceted etiology is thought to be influenced by genetic susceptibility, alterations in the
neurovascular and immune systems, and altered interactions with the microbiota. Strong connections broaden our understanding of Rosacea,
linking it to neurological conditions like Parkinson's disease and gastrointestinal issues such as Helicobacter pylori infection and small intestinal
bacterial overgrowth (SIBO), supporting the existence of an intricate brain-gut-skin connection. The interplay between these organs' homeostatic
and regulatory systems is increasingly evident. While we have not fully grasped the details of immunological, neuroendocrine, and metabolic
pathways, it is clear they play a part in chronic inflammatory skin conditions like Rosacea. Delving into these intricate pathways promises a
nuanced comprehension of the disease's etiopathogenesis. An in-depth investigation into the roles of dysbiotic microbiota and dysregulated innate
immune responses is imperative to comprehensively fathom Rosacea's pathophysiological landscape. A refined grasp of this condition and the gutskin
axis holds the potential for optimizing therapeutic trajectories. The purpose of this review is to explore potential bacterial indicators of the
disease and to assess whether the gut microbiome makeup of individuals with inflammatory Rosacea differs from that of healthy controls.
Furthermore, it critically assesses and consolidates previously documented alterations in peripheral blood, skin, and gastrointestinal tract
microbiomes within rosacea patients. This review illuminates the intricate dance of microbiota in the context of Rosacea, forging a bridge between
cutting-edge insights and its implications. By synthesizing current knowledge, this review advances our understanding of microbiota-driven
mechanisms in inflammatory Rosacea, paving the way for innovative therapeutic strategies.
A Review on Privacy Protection Techniques in Smart Grid Applications
Authors: Gupta Rakhi , Singh Parminder , Kaur Avinash , Hedabou Mustapha
Published: November 2023

:

The extensive use of electricity and the increasing number of consumers challenge
matching power consumption with the power generated. Having a traditional way of power generation and distribution, power is also widely fetched through renewable energy sources. So, to
have improved efficiency and reliable means of the power source, to be able to integrate multiple
sources of power generation like PV Cells, Solar Power, and Wind Power into the existing
standards of the power source, precise calculations of the power consumption in the multisource
environment, provision to scale up the smart and electric vehicle and most importantly, to reduce
the carbon emissions, several attempts have been made to convert the traditional grids into smart
grids. A tiny step in the smart grid's development is the smart metering infrastructure, in which
smart meters are deployed through the consumer end. Through smart meters, it is possible to
establish the link, either through wireless media or wired connections, between the consumer and
the grid. Once the smart meters are deployed through the Advanced Metering Infrastructure
(AMI), the meters remain active round the clock, giving a window to hackers. Through this window, utility bill manipulations, payment transaction information, and other significant data can
be accessed by unethical approaches and threaten the consumer's privacy. This review-research
paper discusses various methods presented by distinct authors to address the issues related to
customer privacy protection in the smart grid.
Dezinformacja w dobie cyfryzacji
Authors: Ogiński Marcin
Published: November 2023

Rozwój Internetu stworzył pole do zagospodarowania przestrzeni, w której informacje rozchodzą się w tempie błyskawicznym po całym świecie. Zwiększeniu liczby interakcji pomaga rozwój mediów społecznościowych. W takiej sytuacji użytkownik Internetu może stać się podatny na wszystkie pojawiające się informacje, także te fałszywe, które stają się narzędziem manipulacji i dezinformacji. Obecnie, można to dostrzec szczególnie w czasie toczącej się wojny Rosji i Ukrainy, której silnym orężem, zarówno po jednej, jak i drugiej stronie, jest wojna informacyjna. Są jednak narzędzia i inicjatywy, które pomagają walczyć o prawdę takie jak między innymi Brand24 czy Media Check. Celem artykułu jest prześledzenie najważniejszych pojęć i powiązań w kontekście wykorzystania dezinformacji w dobie cyfryzacji, a także odpowiedź na pytanie, czy zwykły użytkownik Internetu pozostaje całkowicie bezbronny wobec pojawiających się na szeroką skalę fake newsów.
An Analysis of Reservation Writing in Where the Pavement Ends from the Perspective of Internal Colonialism
Authors: Suyang Gao
Published: November 2023

William Yellow Robe Jr.’s Where the Pavement Ends: Five Native American Plays is his representative drama collection published in 2000. These five dramas faithfully present Indian’s life in Reservation in the 1970s. Based on the perspective of Internal Colonialism, this paper reveals the economic situation, political rights, and Civil Movement of Indian in Reservation. How does the Reservation System affect Indian in the 20th Century? This essay argues that Indian Reservation is the product of White colonization, and the negative effects brought by Whites’ colonization cannot be eliminated. Even today, Indian still struggles to find their place in American society.
Morbimortabilidade hospitalar por neoplasias malignas de lábio, cavidade oral e faringe em hospitais públicos baianos
Authors: Santana Rodolfo dos Santos , Queiroz Letícia Silva das Virgens , Santos Aline Barbosa dos
Published: November 2023

Os cânceres orais, juntamente com os cânceres faríngeos, estão entre os dez tipos mais comuns de cânceres ocorrentes em todo o mundo, principalmente em países subdesenvolvidos. Poucos estudos têm avaliado as características epidemiológicas e clínico-patológicas do câncer oral no Brasil, e a maioria deles foi conduzida na região Sudeste do país, refletindo a escassez de informações relativas a esse tipo de neoplasia no Nordeste brasileiro. O objetivo deste artigo foi avaliar os aspectos epidemiológicos de morbimortalidade por neoplasias malignas de lábio, cavidade oral e faringe de pacientes atendidos em hospitais públicos no estado da Bahia no período de 2018 a 2022. Trata-se de um estudo descritivo e exploratório, com coleta de dados secundários de mortalidade e morbidade hospitalar, disponibilizados no banco de dados do Sistema Único de Saúde (Datasus) do Brasil. Ao todo, foram registradas 6.527 internações por neoplasias malignas. Identificou-se que as regiões Leste, Centro-Leste e Sudoeste apresentaram a maior proporção de usuários hospitalizados, correspondendo a 25,5%, 21,6% e 13,3%, respectivamente. Foram registrados 880 óbitos. Observa-se que a maior morbimortalidade hospitalar ocorreu em homens pretos e pardos na faixa etária de 50 a 69 anos.
Prevalência de síndrome de burnout em médicos intensivistas de uma cidade no nordeste do Brasil
Authors: Góis Joselice Almeida , Santos Cleide Lucilla Carneiro , Aragão Núbia Samara Caribé de , Barbosa Gabriella Bené , Nascimento Mônica de Andrade , Sobrinho Carlito Lopes Nascimento
Published: November 2023

Estudos apontam que médicos intensivistas podem sofrer com estresse crônico e insatisfação em relação à sua atividade laboral, o que pode gerar desgaste físico e mental nesses trabalhadores. Objetivou-se, no presente estudo, estimar a prevalência e os fatores associados à síndrome de burnout em médicos trabalhadores de Unidade de Terapia Intensiva (UTI) de uma cidade da Bahia. Foi realizado estudo epidemiológico de corte transversal em uma população de 53 médicos trabalhadores de terapia intensiva na cidade de Feira de Santana, Bahia. Um questionário autoaplicável avaliou dados sociodemográficos, características do trabalho e a síndrome de burnout por meio do Maslach Burnout Inventory (MBI). A prevalência da síndrome de burnout foi de 45,3%. A exaustão emocional foi a dimensão mais afetada entre os trabalhadores estudados, 45,0%. Observou-se associação entre variáveis sociodemográficas e características do trabalho; sexo, idade, situação conjugal, renda, tempo de trabalho, carga horária de plantão em UTI, plantão noturno, carga horária total semanal em UTI, carga horária total semanal de trabalho, vir de outro trabalho antes do plantão na UTI e síndrome de burnout. Observou-se elevada prevalência e associação entre variáveis sociodemográficas e características do trabalho e a síndrome de burnout entre os médicos intensivistas estudados. Faz-se necessário refletir sobre quais medidas poderiam ser adotadas no sentido de modificar as condições de trabalho, as relações sociais nesse ambiente laboral e a motivação desses trabalhadores.
Prevention of Pressure Injury from Elastic Ear Loop of Face Masks: A Technical Report with Review of Literature
Authors: Mukram Ali Fareedi , Saeed Wasli Abdullah , Hobani Abbas Hasan , Al Faraj Samira Hussain , Hamoud Mashiakhy Essa , Mohammed Alkhayrat Ali , Khawaji Reem Abdullah
Published: November 2023

Protective masks are widely used today to prevent the spread of microorganisms, especially masks used duringsurgery with elastic loops. When the mask is worn for several hours a day, these stretching bands constantly press against theskin, resulting in pressure on the cartilage of the auricle, resulting in erythematous and painful lesions on the skin behind theauricle. Wearing masks for extended periods is now common with patients and members of the public. There is pressure harmto the ear while using this mask often over time. As a result, individuals continually change the mask to release the pressure,which raises their risk of contracting infection. The damage to the ears and auricles can be a side effect of continued use andshould be recognized by doctors and other health care professionals. This article focuses on a new technique to reduce strainon the ear loops of surgical masks. Also, it reviews the common ear injuries or pressure injuries on the ear published in theliterature related to prolonged use of masks and their preventive strategies.
Editorial: Corporate sustainability, green economy, and entrepreneurial financing in emerging markets
Authors: Boasiako Kwabena
Published: November 2023

Welcome to the latest issue of the journal “Corporate and Business Strategy Review”. We express our profound gratitude to all contributors (authors, editorial board, publisher) of the journal and those who have served as anonymous referees for the published papers in this issue. This issue includes articles focused on a variety of relevant as well as actual topics in corporate sustainability, green economy, and business strategy, all consistent with the main research areas targeted by the journal.
Mechanical properties of marble with different joint inclinations under engineering disturbance
Authors: Lou Chen-Di , Xie Jing , Zha Er-Sheng , Ru Zhang , Ren Li , Zhang Ze-Tian , Liu Xiao-Ling , Xiao Kun
Published: November 2023

This study examined the fracture morphology properties of rock cores and
studied the mechanical characteristics of jointed rock at depths of 2400 m,
with inclinations of 15?, 30?, and 60?. The results showed that jointed
rock is significantly controlled by joint weak areas, particularly when the
joint inclination exceeds 30?. Additionally, rock damage increases with
joint inclination during engineering disturbance, however, its pre-peak
plastic characteristics weaken with joint inclination. The damage stress
level is higher with a larger joint inclination, decreasing the bearing
capacity. Further, a strength criterion for jointed rock considering
engineering disturbance was established. It is found that strength exhibits
a V-shaped distribution with joint inclination, and 30? to 75? jointed rock
is significantly lower than before the disturbance.
Kinetic and Equilibrium Studies of Methylene Blue Adsorption on Alstonia Scholaris Plant Leaf Powder
Authors: SD Pardeshi
Published: November 2023

In the current work the methylene blue removal using leaf powder of Alstonia Scholaris was investigated. Pseudo first order, second order and Elovic model ware applied, it has been observed that the adsorption follows second order kinetic model. The isotherm study was done by using Langmuir, Temkin and Freundlich isotherm, the Freundlich isotherm was best suited for present investigation. The maximum adsorption was observed at pH 7.5.
Dionisio Rodríguez Castillo, su aportación a la imprenta en Guadalajara y su labor benéfica por los más necesitados
Authors: Miranda Báez Alba del Carmen
Published: November 2023

El objetivo general de esta investigación ha sido recopilar información que revelara la labor altruista que realizó Dionisio Rodríguez, un jalisciense que vivió en Guadalajara, Jalisco (México), hacia mediados del siglo XIX. Un hombre ejemplar conocido por sus obras benéficas en pro de los desvalidos, reconocido en el contexto temporal en que vivió, aunque olvidado a través de los años. Hoy en día es valorado como impresor y propagador de las letras, pero también fue una persona que hizo obra benéfica en la ciudad, por lo que dejó huella en quienes lo conocieron.

La información recabada ha permitido mostrar que Rodríguez ayudó a cientos de personas a través de la Escuela de Artes y Oficios, y otras labores de beneficiencia local. Cuando murió, Guadalajara se paralizó. A su velorio acudieron cerca de quince mil personas, cuando en aquellos años la ciudad contaba con alrededor de ochenta mil. Era tal su valoración, que al día siguiente (2 de mayo de 1877) se le nombró benemérito del estado de Jalisco.
The Role of Audio Books and Video Books in English Language Teaching (ELT
Authors: Alone Sunil Dattatraya
Published: November 2023

The integration of audio books and video books into English Language Teaching (ELT) has transformed traditional language learning methods. This research paper explores the evolving role of these multimedia resources in ELT, investigating their benefits, challenges, and pedagogical implications. Through an in-depth analysis of relevant literature, this study examines how audio books and video books enhance listening skills and comprehension, facilitate vocabulary acquisition, cultural immersion and contextual understanding, fosters motivation and engagement, caters to diverse learning styles, and provide authentic language exposure. Furthermore, the paper discusses effective pedagogical strategies for integrating these resources into ELT classrooms. By synthesizing theoretical insights and practical examples, this paper highlights the potential of audio books and video books to create immersive language learning experiences that bridge the gap between classroom instruction and real-world language use.
Ahead to the Past: The Return of the Delegated Leadership Convention
Authors: Stewart David K , Stewart Ian
Published: November 2023

The paper examines the leadership convention held by the Nova Scotia Conservatives in 2006. Based on a survey of delegates to that convention as well as elite interviews, the paper examines the rationale for the party's retreat from the universal ballot.

Examination of the process is focused on the rationale offered by the party, namely to have a more fair, equal, and exciting process. Following a discussion of each of these issues, the paper concludes that the party fell short on its own measures and the retreat from a universal ballot was far from strategic.
El comercio español de ganado vivo
Authors: Calcedo Ordóñez Victoriano
Published: November 2023

En la actividad de los Mercados Nacionales (2008-2021) ha existido un declive desde los últimos noventa hasta 2007. Desde entonces se estabiliza en 500.000 bovinos entrados. Todos los Mercados decrecen, excepto el de Salamanca. Cuatro copan la concurrencia: Pola de Siero, Santiago de Compostela, Salamanca y Torrelavega rebasan 100.000 cabezas en 2018 y 2019, no en 2020 por la Covid-19, casi recuperadas en 2021. Desarrollan esencialmente sus operaciones en ganado de hasta un año de vida.
El comercio exterior de ganado ha sido muy activo durante el período contemplado, el de importación con tendencia creciente, y también el de exportación, sobre todo a terceros países, desde el inicio de las exportaciones a países del Mediterráneo en 2010. En las exportaciones los animales más solicitados son los que superan 300 kilos. En las importaciones predominan los de menos de 80 kilos, demandados por los cebaderos españoles.
Efecto del epoxiconazol en mezclas sobre Puccinia striiformis f. sp. tritici en el cultivo de trigo
Authors: Faberi Ariel Jesus , Erreguerena Ignacio , Clemente Natalia Liliana , Carlón Matías
Published: November 2023

Los fungicidas son la principal estrategia de manejo de roya estriada por Puccinia striiformis f. sp. tritici en trigo. El objetivo fue evaluar el aporte del epoxiconazol sobre el control de roya estriada. El ensayo se realizó en un lote de trigo (Algarrobo, Don Mario) (37°53'46.70"S; 58°13'16.49"O) bajo diseño en bloques completos aleatorizados, cuatro repeticiones. La unidad experimental consistió en parcelas de 3 x 8 m. Los tratamientos fueron: testigo; 0,45 L.ha-1 pyraclostrobina (P)/ boscalid (B); 0,23 L.ha-1 P/B + 0,75 L.ha-1 epoxiconazol (E); 0,45 L.ha-1 P/B  + 0,75 L.ha-1 E y 0,75 L.ha-1 P/B + 0,75 L.ha-1 E, y se aplicaron en Z31 (roya estriada: 35 % incidencia en hoja, 3,3 % severidad). Se determinó incidencia y severidad a los 15, 32, 57 días después de la aplicación (DDA) y el rendimiento. Las variables se analizaron mediante modelos mixtos. La incidencia en hoja bandera y en las tres inferiores fue menor en los tratamientos con epoxiconazol respecto a la doble mezcla PB y al testigo a los 15 y 32 DDA. A los 15, 32 y 57 DDA la severidad en los tratamientos con epoxiconazol fue menor al testigo y al de doble mezcla. Hubo un aporte significativo de 1438 Kg.ha-1 en el rendimiento del tratamiento de doble mezcla. En los tratamientos con epoxiconazol el incremento en el rendimiento fue superior a 4000 Kg.ha-1. Se concluye que la incorporación de epoxiconazol a la mezcla mostró resultados promisorios desde los puntos de vista sanitario y productivo del cultivo.