bluuebunny/crossref_metadata_2025 huggingface dataset:
Alternative Data for Configurable and Personalized Commercial Insurance Products
Authors: Albo Carlos
Published: April 2022

The insurance sector has a very low degree of products’ personalization. This is because insurance companies are not adequately using the vast amounts of information that is available online. This chapter presents the under-explored avenue of using alternative or nontraditional sources of information to obtain data for the configuration of personalized insurance offers. Specifically, it illustrates how big data, synthetic data, and machine learning models can be used to draw up the risk map of companies in an individualized way. It also presents methods for constructing and offering insurance programs that are personalized to each business reality.
Towards Optimal Technological Solutions for Central Bank Digital Currencies
Authors: Dionysopoulos Lambis , Giaglis George
Published: April 2022

In this chapter, we provide a historic overview of the origin and definitions of Central Bank Digital Currencies (CBDCs), by examining relevant research dating back to the 1990s. We find that digital versions of sovereign money accessible by the private sector were motivated by advancements and challenges emerging from the private sector itself. We present the factors that necessitate their issuance, and especially focus on financial stability, monetary policy, and the increased competition in payments leading to threats in financial and monetary sovereignty. Finally, we assess the appeal of the various technical options for CBDCs against what has emerged as their universally desirable features.
Historic Overview and Future Outlook of Blockchain Interoperability
Authors: Dionysopoulos Lambis
Published: April 2022

For three decades, the Bitcoin network processes transactions collectively worth billions in a fully decentralized and trustless way. Its introduction as a way for disintermediating financial institutions came at a time of rising dismay against the establishment due to the financial collapse of 2008. Bitcoin’s rising popularity gave birth to the realization that its underlying technologies could be utilized for other use-cases besides money. This gave rise to imitators, iterators and ultimately a diverse ecosystem of protocols and applications. In most cases, those aforementioned protocols employed technologically proprietary approaches even when aiming to solve similar problems. Today, those separate networks stand as monolithic structures, with no knowledge of information that might exist on another. As such they are hostages to their non-interoperable nature and bound to hardcoded decisions. Their attempts at change often result in divided communities and further balkanization. This dissolution threatens the integrity of the decentralized space, as desolate systems are susceptible to manipulation. Some believe that the future of the wider decentralised ecosystem will rely on a Web 3.0 internet-like infrastructure that will allow for seamless integration and the free exchange of information between systems. In this chapter, we will explore the source of the limitations of blockchain systems, provide a historical overview of current and past interoperable approaches and discuss present and future solution design.
Dual D-brane actions in nonrelativistic string theory
Authors: Ebert Stephen , Sun Hao-Yu , Yan Ziqi
Published: April 2022

Abstract

We study worldvolume actions for D-branes coupled to the worldvolume U(1) gauge field and Ramond-Ramond (RR) potentials in nonrelativistic string theory. This theory is a self-contained corner of relativistic string theory and has a string spectrum with a Galilean-invariant dispersion relation. We therefore refer to such D-branes in nonrelativistic string theory as nonrelativistic D-branes. We focus on the bosonic fields in spacetime and also couple the D-branes to general closed string geometry, Kalb-Ramond, and dilaton background fields. We dualize nonrelativistic D-branes by performing a duality transformation on the worldvolume U(1) gauge field and uncover novel dual D-brane actions. This generalizes familiar properties, such as the SL(2, ℤ) duality in Type IIB superstring theory and the relation between Type IIA superstring and M-theory, to nonrelativistic string and M-theory. Moreover, we generalize the limit of string theory, in which nonrelativistic string theory arises, to include RR potentials. This stringy limit induces a codimension-two foliation structure in spacetime. This spacetime geometry is non-Riemannian and known as string Newton-Cartan geometry. In contrast, nonrelativistic M-theory that we probe by dualizing D2- and D4-branes in nonrelativistic string theory arises as a membrane limit of M-theory, and it is coupled to a membrane Newton-Cartan geometry with a codimension-three foliation structure. We also discuss T-duality in nonrelativistic string theory and generalize Buscher rules from earlier work to include RR potentials.
Dynamical stability and filamentary instability in holographic conductors
Authors: Ishigaki Shuta , Kinoshita Shunichiro , Matsumoto Masataka
Published: April 2022

Abstract

In this study, we analyze the dynamical stability of the D3-D7 model dual to a holographic conductor with a constant current under an external electric field. We particularly focus on the stability around the parameter region where the multivalued relation between the external electric field and the current is shown due to nonlinear conductivity. The dynamical stability of the states can be analyzed by considering linear perturbations in the background states and computing the quasinormal modes. In the multivalued region, we find that the states in one branch with a low electric current can be dynamically unstable. The turning point in the J–E characteristic coincides with the stability switching. Further, we also find that the perturbations around the unstable states can become stable with finite wavenumber. In other words, the perturbations in the background states become static at a critical wavenumber, implying the existence of inhomogeneous steady states with current filaments.
The CannTeen study: verbal episodic memory, spatial working memory, and response inhibition in adolescent and adult cannabis users and age-matched controls
Authors: Lawn W. , Fernandez-Vinson N. , Mokrysz C. , Hogg G. , Lees R. , Trinci K. , Petrilli K. , Borissova A. , Ofori S. , Waters S. , Michór P. , Wall M. B. , Freeman T. P. , Curran H. V.
Published: April 2022

Background

Preclinical and human studies suggest that adolescent cannabis use may be associated with worse cognitive outcomes than adult cannabis use. We investigated the associations between chronic cannabis use and cognitive function in adolescent and adult cannabis users and controls. We hypothesised user-status would be negatively associated with cognitive function and this relationship would be stronger in adolescents than adults.

Methods

As part of the ‘CannTeen’ project, this cross-sectional study assessed cognitive performance in adolescent cannabis users (n = 76; 16–17-year-olds), adolescent controls (n = 63), adult cannabis users (n = 71; 26–29-year-olds) and adult controls (n = 64). Users used cannabis 1–7 days/week. Adolescent and adult cannabis users were matched on cannabis use frequency (4 days/week) and time since last use (2.5 days). Verbal episodic memory (VEM) was assessed using the prose recall task, spatial working memory (SWM) was assessed using the spatial n-back task, and response inhibition was assessed with the stop-signal task. Primary outcome variables were: delayed recall, 3-back discriminability, and stop signal reaction time, respectively.

Results

Users had worse VEM than controls (F(1,268) = 7.423, p = 0.007). There were no significant differences between user-groups on SWM or response inhibition. Null differences were supported by Bayesian analyses. No significant interactions between age-group and user-group were found for VEM, SWM, or response inhibition.

Conclusions

Consistent with previous research, there was an association between chronic cannabis use and poorer VEM, but chronic cannabis use was not associated with SWM or response inhibition. We did not find evidence for heightened adolescent vulnerability to cannabis-related cognitive impairment.
Predation on planted and wild bay scallops (Argopecten irradians irradians) by busyconine whelks: studies of behavior incorporating acoustic telemetry
Authors: Sclafani M. , Bopp J. , Havelin J. , Humphrey C. , Hughes S. W. T. , Eddings J. , Tettelbach S. T.
Published: April 2022

Quantifying predator–prey interactions and gaining insights into predator behavior are crucial for optimizing restoration strategies. However, such knowledge is often lacking for marine invertebrates. We examined potential impacts of predation by channeledBusycotypus canaliculatusand knobbed whelksBusycon caricaon natural and planted populations of bay scallops in the Peconic Bays, New York, through laboratory and field investigations. In lab experiments, mean predation rates exhibited by small channeled whelks were low: 0.06 and 0.005 scallops d−1for adult and juvenile scallops, respectively. Predation rates of small knobbed whelks on juvenile scallops were 22 × higher. Eighty-six percent (86%) of scallops consumed by channeled whelks had undamaged shells, while 73% eaten by knobbed whelks had notched ventral margins. In field plots where scallop densities were manipulated via removals/plantings, whelks consumed ~ 2% of ~ 19,100 planted juveniles, whereas crabs and presumably finfish consumed > 40% overall. Acoustic telemetry revealed that tagged channeled whelks moved shorter distances and spent more time in plots planted with scallops versus those without scallops. Whelks spent more time in low versus high-density plots, but consumed far more scallops in the latter. In trials without scallops, whelk movement rates were 5 × higher, presumably due to increased exploratory behavior. Overall, whelks were most active during crepuscular hours and during periods of increasing wind speeds. Our results, combined with population abundance data, suggest that whelks (especiallyB. carica) are drawn to planted bay scallop aggregations, but probably contribute to relatively low overall mortality in the context of restoration efforts.
The First Evaluation of Remote Magnetic Navigation-Guided Pediatric Ventricular Arrhythmia Ablation
Authors: Noten Anna M. E. , Ramdat Misier Nawin L. , Kammeraad Janneke A. E. , Wijchers Sip , Van Beynum Ingrid M. , Dalinghaus Michiel , Krasemann Thomas B. , Yap Sing-Chien , de Groot Natasja M. S. , Szili-Torok Tamas
Published: April 2022

Catheter ablation (CA) is an important treatment option for ventricular arrhythmias (VA) in pediatric cardiology. Currently, various CA techniques are available, including remote magnetic navigation (RMN)-guided radiofrequency (RF) ablation. However, no studies evaluate RMN-guided ablative therapy outcomes in children with VA yet. This study aimed to compare procedural and long-term outcomes between RMN-guided and manual (MAN)-guided VA ablation in children. This single-center, retrospective study included all CA procedures for VA performed in children with or without structural heart disease from 2008 until 2020. Two study groups were defined by CA technique: RMN or MAN. Primary outcome was recurrence of VA. Baseline clinical, procedural and safety data were also evaluated. This study included 22 patients, who underwent 30 procedures, with a median age of 15 (IQR 14–17; range 1–17) years and a mean weight of 57 ± 20 kg. In total, 14 procedures were performed using RMN and 16 using MAN (22 first and 8 redo procedures). Regarding first procedures, recurrence rates were significantly lower in RMN compared to MAN (20% versus 67%, P = 0.029), at a mean follow-up of 5.2 ± 3.0 years. Moreover, fluoroscopy dosages were significantly lower in RMN compared to MAN [20 (IQR 14–54) versus 48 (IQR 38–62) mGy, P = 0.043]. In total, 20 patients (91%) were free of VA following their final ablation procedure. This is the first study to investigate the use of RMN in pediatric VA ablation. RMN showed improved outcomes compared to MAN, resulting in lower VA recurrence and reduced fluoroscopy exposure.
Host-Associated Bacterial Communities Vary Between Daphnia galeata Genotypes but Not by Host Genetic Distance
Authors: Rajarajan Amruta , Wolinska Justyna , Walser Jean-Claude , Dennis Stuart R. , Spaak Piet
Published: April 2022

Host genotype may shape host-associated bacterial communities (commonly referred to as microbiomes). We sought to determine (a) whether bacterial communities vary among host genotypes in the water flea Daphnia galeata and (b) if this difference is driven by the genetic distance between host genotypes, by using D. galeata genotypes hatched from sediments of different time periods. We used 16S amplicon sequencing to profile the gut and body bacterial communities of eight D. galeata genotypes hatched from resting eggs; these were isolated from two distinct sediment layers (dating to 1989 and 2009) of a single sediment core of the lake Greifensee, and maintained in a common garden in laboratory cultures for 5 years. In general, bacterial community composition varied in both the Daphnia guts and bodies; but not between genotypes from different sediment layers. Specifically, genetic distances between host genotypes did not correlate with beta diversity of bacterial communities in Daphnia guts and bodies. Our results indicate that Daphnia bacterial community structure is to some extent determined by a host genetic component, but that genetic distances between hosts do not correlate with diverging bacterial communities.
Comparing the diagnostic performance of radiotracers in prostate cancer biochemical recurrence: a systematic review and meta-analysis
Authors: Ma Weili , Mao Jiwei , Yang Jianfeng , Wang Ting , Zhao Zhen Hua
Published: April 2022

Objectives

To systematically assess the early detection rate of biochemical prostate cancer recurrence using choline, fluciclovine, and PSMA.

Methods

Under the guidance of the Preferred Reporting Items for Systematic reviews and Meta-Analysis Diagnostic Test Accuracy guidelines, literature that assessed the detection rates (DRs) of choline, fluciclovine, and PSMA in prostate cancer biochemical recurrence was searched in PubMed and EMBASE databases for our systematic review from 2012 to July 15, 2021. In addition, the PSA-stratified performance of detection positivity was obtained to assess the DRs for various methods, including fluciclovine, PSMA, or choline PET/CT, with respect to biochemical recurrence based on different PSA levels.

Results

In total, 64 studies involving 11,173 patients met the inclusion criteria. Of the studies, 12, 7, and 48 focused on choline, fluciclovine, and PSMA, respectively. The pooled DRs were 24%, 37%, and 44%, respectively, for a PSA level less than 0.5 ng/mL (p < 0.001); 36%, 44%, and 60% for a PSA level of 0.5–0.99 ng/mL (p < 0.001); and 50%, 61%, and 80% for a PSA level of 1.0–1.99 ng/mL (p < 0.001). The DR with 18F-labeled PSMA was higher than that with 68Ga-labeled PSMA, and the DR was 58%, 72%, and 88% for PSA levels < 0.5 ng/mL, 0.5–0.9 ng/mL, and 1.0–1.99 ng/mL, respectively.

Conclusion

The DRs of PSMA-radiotracers were greater than those of choline-radiotracers and fluciclovine-radiotracers at the patient level. 18F-labeled PSMA achieved a higher DR than 68Ga-labeled PSMA.

Key Points

• The DRs of PSMA-radiotracers were greater than those of choline-radiotracers and fluciclovine-radiotracers at the patient level.

•18F-labeled PSMA achieved a higher DR than68Ga-labeled PSMA.
The Asymmetric Connection of SST in the Tasman Sea with Respect to the Opposite Phases of ENSO in Austral Summer
Authors: Sun Xueqian , Li Shuanglin , Liess Stefan
Published: April 2022

This study uses linear regression and composite analyses to identify a pronounced asymmetric connection of sea surface temperature (SST) in the Tasman Sea with the two opposite phases of El Niño-Southern Oscillation (ENSO) during austral summer. In El Niño years, the SST anomalies (SSTAs) in the Tasman Sea exhibit a dipolar pattern with weak warmth in the northwest and modest cooling in the southeast, while during La Niña years the SSTAs exhibit a basin-scale warmth with greater amplitude. Investigations into the underlying mechanism suggest that this asymmetry arises from a mechanism related to oceanic heat transport, specifically the anomalous Ekman meridional heat transport induced by the zonal wind stress anomalies, rather than the surface heat fluxes on the air-sea interface. Further analysis reveals that the asymmetry of oceanic heat transport between El Niño and La Niña years is driven by the asymmetric atmospheric circulation over the Tasman Sea stimulated by the asymmetric diabatic heating in the tropical Pacific between the two opposite ENSO phases.
Impact of bariatric surgery on the effectiveness of serological response after COVID-19 vaccination
Authors: Hany Mohamed , Torensma Bart , Abouelnasr Anwar Ashraf , Zidan Ahmed , Ibrahim Mohamed , Agayby Ann Samy Shafiq , Hesham Mohamed , Elsheredy Amel , Abu-Sheasha Ghada Ahmed
Published: April 2022

Purpose

The primary objective of the current study is to determine whether bariatric surgery reversed the negative impact of obesity on the serological response after the COVID-19 vaccination. This objective is achieved in two steps: (a) quantifying the negative impact of obesity on the serological response after COVID-19 vaccination if it is present, and (b) testing whether bariatric surgery reversed this impact. The secondary objective was to monitor the occurrence of adverse events.

Methods

This is a prospective cohort study between May 2021 and August 2021 on the strength of serological response after COVID-19 vaccination. Patients were classified into three groups. Group A (controls with normal or overweight), Group B (bariatric patients pre-operative), and Group C (bariatric patients post-operative). Quantitative antibodies against SARS‑CoV‑2 RBD with a strong neutralizing capacity were quantified from sera after at least 2 weeks post-vaccination.

Results

Of the 276 participants, Group A had n = 73, Group B had n = 126, and Group C had n = 77 patients. Overall, a strongly positive vaccine serological response was observed among 86% in group A, 63% in Group B, and 88% in Group C. Group C showed 5.33 times [95% CI 2.15 to 13.18] higher immune response than group B. Mild to moderate adverse events occurred in 30.1% [95% CI 24.7 to 35.9] of the study samples. Adverse events with the whole virus, mRNA, and vector vaccines occurred in 25%, 28%, and 37%, respectively.

Conclusion

Vaccinating and bariatric surgery are safe and effective treatments in the serological response in patients who suffer from obesity.
Numerical analysis of the magnetic shape memory effect based on the absolute nodal coordinate formulation
Authors: Wang Tengfei , Nemov Alexander S. , Matikainen Marko K. , Mikkola Aki
Published: April 2022

In this paper, the absolute nodal coordinate formulation (ANCF) is applied to simulate the magnetic shape memory effect. Using the absolute nodal coordinate formulation makes it possible to describe complicated or large deformation cases. The nonlinear bidirectional coupling terms between the mechanical and magnetic field are taken into account in the analysis of the single-crystalline Ni-Mn-Ga sample. A two-loop iteration procedure with variable steps is implemented to predict the magnetic-field-induced strain (MFIS) in the specimen under a changing external magnetic field and a constant auxiliary compression. In addition, the proposed approach is used to track the superelastic behavior of the magnetic shape memory alloy when subjected to a constant magnetic field. The approach effectively describes the hysteresis and superelastic phenomenon of the shape memory effect. The solution is compared here with solutions obtained using classical linear and quadratic quadrilateral elements. The deviation observed in the solution is discussed, and its cause is further clarified from a two-domain pure magnetostatic analysis of a permanent magnet. It is found that the accurate solution of such problems is associated with discontinuity of the normal component of the magnetic potential gradient across the domain interface. Special measures must be taken to make the absolute nodal coordinate formulation element compatible with the discontinuity. A mixed FEs strategy, which adopts ANCF FE in the displacement field solver and classical FE in the magnetic field solver, is proposed as an alternative option to rectify the problem, which is verified by predicting the MFIS and the dynamic mechanical response of a sample under cyclic compression.
Mixed finite elements applied to acoustic wave problems in compressible viscous fluids under piezoelectric actuation
Authors: Meindlhumer Martin , Pechstein Astrid , Jakoby Bernhard
Published: April 2022

In the present contribution, we develop a mixed finite element method capable of the coupled multi-field simulation of a viscous fluid actuated by a piezoelectric resonator. Several challenges are met with in this setting, among which are the necessity of correct interface coupling, near incompressibility of the fluid, adverse geometric dimensions of flat piezoelectric transducers and different length scales of shear and pressure wave. Assuming small deformations and velocities, we present a mixed variational formulation with consistent interface coupling conditions in (mechanic) frequency domain. Both fluid and piezoelectric solid domain are discretized using Tangential-Displacement Normal-Normal-Stress elements. These elements model not only the deformation, but add an independent tensor-valued stress approximation. The method has been rigorously proven to be free from shear locking for flat prismatic or hexahedral elements. Thus, modeling of the flat geometry of piezoelectric resonators as well as resolution of the fastly decaying shear wave are facilitated. To circumvent the problem of volume locking due to the near incompressibility of the fluid, an additional independent pressure field is introduced. We present computational results indicating the capability of the method.
The full story of 1000 cores
Authors: Bang Tiemo , May Norman , Petrov Ilia , Binnig Carsten
Published: April 2022

In our initial DaMoN paper, we set out the goal to revisit the results of “Starring into the Abyss [...] of Concurrency Control with [1000] Cores” (Yu in Proc. VLDB Endow 8: 209-220, 2014). Against their assumption, today we do not see single-socket CPUs with 1000 cores. Instead, multi-socket hardware is prevalent today and in fact offers over 1000 cores. Hence, we evaluated concurrency control (CC) schemes on a real (Intel-based) multi-socket platform. To our surprise, we made interesting findings opposing results of the original analysis that we discussed in our initial DaMoN paper. In this paper, we further broaden our analysis, detailing the effect of hardware and workload characteristics via additional real hardware platforms (IBM Power8 and 9) and the full TPC-C transaction mix. Among others, we identified clear connections between the performance of the CC schemes and hardware characteristics, especially concerning NUMA and CPU cache. Overall, we conclude that no CC scheme can efficiently make use of large multi-socket hardware in a robust manner and suggest several directions on how CC schemes and overall OLTP DBMS should evolve in future.
Impact of sports on temporomandibular dysfunction: a comparison of competitive and recreational female athletes as well as female non-athletes
Authors: Freiwald Hannah Charlotte , Schwarzbach Nico Peter , Wolowski Anne
Published: April 2022

Objectives

The present study was conducted to investigate the correlation between (competitive) sports and the occurrence of temporomandibular dysfunctions (TMD) by comparing the prevalences in competitive, recreational, and non-athletic women.

Materials and methods

A total of 138 women between the ages of 18 and 45 were interviewed about symptoms of TMD by means of a questionnaire. Based on their athletic performance level, the participating women were classified as competitive athletes, recreational athletes, or non-athletes (each group n = 46).

Results

Symptoms of TMD were notably less frequent in competitive female athletes (52.2%) than in recreational female athletes (63.0%) and female non-athletes (60.9%). With increasing training load, the prevalence of TMD decreased in both the competitive and recreational female athlete groups.

Conclusions

Athletic activity in general seems to have a positive effect on the occurrence of TMD. Competitive female athletes appear less likely to suffer from symptoms of TMD than recreational athletes and non-athletes. One possible explanation for this could be the better supervision by qualified trainers and physiotherapists in competitive sports.

Clinical relevance

Patients should be motivated to engage in sports as a protective measure against symptoms of TMD. However, it is important to ensure that they are properly instructed by experienced personnel in order to avoid unphysiological strain and negative consequences.
Influence on the patient’s oral hygiene depending on the treatment performed by either one or different pre-graduate practitioners — a randomized, controlled, clinical short-term trial
Authors: Herz Marco M. , Celebi Nora , Bruckner Thomas , Bartha Valentin
Published: April 2022

Objectives

Plaque control by improved domestic oral hygiene is essential in periodontal treatment. However, changing treatment providers may interfere with building a dentist-patient relationship and in turn affect treatment success. The aim of this randomized, controlled, prospective short-term study was to determine the influence of either one or four different pre-graduate practitioners on patients’ oral hygiene parameters during active periodontal therapy.

Material and Methods

A total of 55 patients with periodontitis were allocated to two groups. Within the group “continuous treatment” (CT, n = 27), each patient was treated by one individual practitioner over the treatment period. For patients of the group “discontinuous treatment” (DT, n = 28), treatment in each session was performed by a different practitioner. Periodontal parameters (BOP, PBI, and PCR) were assessed at two timepoints: T1 (baseline) and T2 (end of active therapy).

Results

With CT, the PBI improved in 93% of the patients, compared to 71% with DT (p = 0.048). T1-T2 intragroup analysis showed a statistically significant improvement of all observed clinical parameters with no differences in ∆PBI, ∆BOP, and ∆PCR. Spearman’s correlation analysis revealed a weak correlation between PCR and BOP of CT only.

Conclusions

In the present study, improvement of all parameters was comparable between the groups. PBI, as a parameter displaying patient’s domestic plaque control compliance, improved in more patients from CT than DT. This is possibly indicating an advantage of continuous treatment by one single practitioner.

Clinical relevance

Treatment by either a single practitioner or by multiple, constantly changing practitioners might influence patients’ compliance to modify their behaviour when medically necessary.
Screening of microRNA and mRNA related to secondary hair follicle morphogenesis and development and functional analysis in cashmere goats
Authors: Shang Fangzheng , Wang Yu , Ma Rong , Rong Youjun , Wang Min , Wu Zhihong , Hai Erhan , Pan Jianfeng , Liang Lili , Wang Zhiying , Wang Ruijun , Su Rui , Liu Zhihong , Zhao Yanhong , Wang Zhixin , Li Jinquan , Zhang Yanjun
Published: April 2022

microRNA (miRNA) is a type of endogenous short-chain non-coding RNA with regulatory function found in eukaryotes, which is involved in the regulation of a variety of cellular and biological processes. However, the research on the development of cashmere goat secondary hair follicles is still relatively scarce. In this study, small RNA libraries and mRNA libraries of 45 days, 55 days, 65 days, and 75 days of fetal skin of cashmere goats were constructed, and the constructed libraries were sequenced using Illumina Hiseq4000, and the expression profiles of miRNA and mRNA in cashmere goat fetal skin were obtained. The differentially expressed miRNAs and mRNAs in six control groups were identified and the qRT-PCR experiment shows that the sequencing results are accurate. Sixty-six miRNAs related to secondary hair follicle development were screened, and used TargetScan and miRanda to predict 33 highly expressed miRNA target genes. At the same time, 664 mRNAs related to the development of secondary hair follicles were screened, and GO enrichment and KEGG pathway analysis were performed. It was found that some miRNA target genes were consistent with the screening results of mRNAs related to secondary hair follicle development and were enriched in Notch signaling pathway, TGF-β signaling pathway. Therefore, miR-145-5p-DLL4, miR-27b-3p-DLL4, miR-30e-5p-DLL4, miR-193b-3p-TGF-β1, miR-181b-5p-NOTCH2, and miR-103-3p-NOTCH2 regulatory network related to the development of secondary hair follicles were constructed and the results of dual-luciferase reporter gene assay indicated that there is a targeted relationship between chi-miR-30e-5p and DLL4, which will provide a basis for molecular mechanism of miRNA-mRNA in the development of the hair follicles in cashmere goats.
Principal Components Along Quiver Representations
Authors: Seigal Anna , Harrington Heather A. , Nanda Vidit
Published: April 2022

Quiver representations arise naturally in many areas across mathematics. Here we describe an algorithm for calculating the vector space of sections, or compatible assignments of vectors to vertices, of any finite-dimensional representation of a finite quiver. Consequently, we are able to define and compute principal components with respect to quiver representations. These principal components are solutions to constrained optimisation problems defined over the space of sections and are eigenvectors of an associated matrix pencil.
Introduction pathways of economically costly invasive alien species
Authors: Turbelin Anna J. , Diagne Christophe , Hudgins Emma J. , Moodley Desika , Kourantidou Melina , Novoa Ana , Haubrock Philip J. , Bernery Camille , Gozlan Rodolphe E. , Francis Robert A. , Courchamp Franck
Published: April 2022

Introduction pathways play a pivotal role in the success of Invasive Alien Species (IAS)—the subset of alien species that have a negative environmental and/or socio-economic impact. Pathways refer to the fundamental processes that leads to the introduction of a species from one geographical location to another—marking the beginning of all alien species invasions. Increased knowledge of pathways is essential to help reduce the number of introductions and impacts of IAS and ultimately improve their management.Here we use theInvaCostdatabase, a comprehensive repository on the global monetary impacts of IAS, combined with pathway data classified using the Convention on Biological Diversity (CBD) hierarchical classification and compiled from CABI Invasive Species Compendium, the Global Invasive Species Database (GISD) and the published literature to address five key points. Data were available for 478 individual IAS. For these, we found that both the total and annual average cost per species introduced through the ‘Stowaway’ (US$144.9bn; US$89.4m) and ‘Contaminant’ pathways (US$99.3bn; US$158.0m) were higher than species introduced primarily through the ‘Escape’ (US$87.4bn; US$25.4m) and ‘Release’ pathways (US$64.2bn; US$16.4m). Second, the recorded costs (both total and average) of species introduced unintentionally was higher than that from species introduced intentionally. Third, insects and mammals, respectively, accounted for the greatest proportion of the total cost of species introduced unintentionally and intentionally respectively, at least of the available records; ‘Stowaway’ had the highest recorded costs in Asia, Central America, North America and Diverse/Unspecified regions. Fourthly, the total cost of a species in a given location is not related to the year of first record of introduction, but time gaps might blur the true pattern. Finally, the total and average cost of IAS were not related to their number of introduction pathways. Although our findings are directly limited by the available data, they provide important material which can contribute to pathway priority measures, notably by complementing studies on pathways associated with ecologically harmful IAS. They also highlight the crucial need to fill the remaining data gaps—something that will be critical in prioritising limited management budgets to combat the current acceleration of species invasions.
Comparison of continuity equation and Gaussian mixture model for long-term density propagation using semi-analytical methods
Authors: Sun Pan , Colombo Camilla , Trisolini Mirko , Li Shuang
Published: April 2022

This paper compares the continuum evolution for density equation modelling and the Gaussian mixture model on the 2D phase space long-term density propagation problem in the context of high-altitude and high area-to-mass ratio satellite long-term propagation. The density evolution equation, a pure numerical and pointwise method for the density propagation, is formulated under the influence of solar radiation pressure and Earth’s oblateness using semi-analytical methods. Different from the density evolution equation and Monte Carlo techniques, for the Gaussian mixture model, the analytical calculation of the density is accessible from the first two statistical moments (i.e. the mean and the covariance matrix) corresponding to each sub-Gaussian distribution for an initial Gaussian density distribution. An insight is given into the phase space long-term density propagation problem subject to nonlinear dynamics. The efficiency and validity of the density propagation are demonstrated and compared between the density evolution equation and the Gaussian mixture model with respect to standard Monte Carlo techniques.
Papyrus production revisited: differences between ancient and modern production modes
Authors: Bausch Florian , Rosado Mario J. , Rencoret Jorge , Marques Gisela , Gutiérrez Ana , Graf Jörg , del Río José C. , Rosenau Thomas , Potthast Antje
Published: April 2022

Papyrus, produced from the white pith of Cyperus papyrus L., has been used for millennia as the major writing support by ancient cultures, but there was no continuous papyrus production until modern times. Therefore, papyrus production had to be rediscovered. Modern Egyptian papyrus producers claim that their sheets possess ‘the same physical and chemical properties as ancient papyri’. To study if this is accurate, commercially available papyrus sheets were compared to ancient papyri and papyri produced according to Pliny’s historic description. Material characterization was performed with a focus on the potentially color-bearing lignin. Two-dimensional nuclear magnetic resonance spectroscopy, derivatization followed by reductive cleavage, and pyrolysis–gas chromatography/mass spectrometry were complemented with microscopy and tests for surface pH and sodium content. The lignin data in the native pith and commercial sheets were compared to 10 ancient samples from the Papyrus Museum Vienna. The analytical data clearly show the involvement of a strong alkaline treatment followed by chlorine bleaching for commercial papyri, as expressed by higher pH values, altered lignin structures, and chlorinated lignin compounds. The inclusion of an alkaline step in ancient papyrus manufacture is discussed but dismissed, since the alkali-treatment causes a huge decrease in lignin content, that was not found for the analysed ancient specimen. We assume that this additional treatment was introduced to obtain yellowish papyrus sheets meeting optical expectations of modern spectators. Linguistic and art historic evidence indicates that such a step would not have made sense in antiquity, since it was desired to produce white papyri.
On the Cost-Effective Temporal Allocation of Credits in Conservation Offsets when Habitat Restoration Takes Time and is Uncertain
Authors: Drechsler Martin
Published: April 2022

Tradable permits, or offsetting schemes, are increasingly used as an instrument for the conservation of biodiversity on private lands. Since the restoration of degraded land often involves uncertainties and time lags, conservation biologists have strongly recommended that credits in conservation offset schemes should be awarded only with the completion of the restoration process. Otherwise, the instrument is claimed to fail on the objective of no net loss in species habitat and biodiversity. What is ignored in these arguments, however, is that such a scheme design may incur higher economic costs than a design in which credits are already awarded at the initiation of the restoration process. In the present paper a generic agent-based ecological-economic simulation model is developed to explore different pros and cons of the two scheme designs, in particular their cost-effectiveness. The model considers spatially heterogeneous and dynamic conservation costs, risk aversion and time preferences in the landowners, as well as uncertainty in the duration and the success of the restoration process. It turns out that, especially under fast change of the conservation costs, awarding credits at the initiation of restoration can be more cost-effective than awarding them with completion of restoration.
A twenty-first century perspective on concepts of modern epidemiology in Ignaz Philipp Semmelweis’ work on puerperal sepsis
Authors: Stang Andreas , Standl Fabian , Poole Charles
Published: April 2022

We aimed to review Semmelweis’s complete work on puerperal sepsis mortality in maternity wards in relation to exposure to cadavers and chlorine handwashing and other factors from the perspective of modern epidemiological methods. We reviewed Semmelweis' complete work and data as published by von Györy 1905 according to current standards. We paid particular attention to Semmelweis's definition of mortality in and of itself, to concepts of modern epidemiology that were already recognizable in Semmelweis's work, and to bias sources. We did several quantitative bias analyses to address selection bias and information bias from outcome measurement error. Semmelweis addressed biases that have become known to modern epidemiology, such as confounding, selection bias and bias from outcome misclassification. Our bias analysis shows that differential loss to follow-up is an unlikely explanation for his results. Bias due to outcome misclassification would only be relevant if misclassification differed between time periods. Confounding by health status was likely but could not be quantitatively addressed. Semmelweis was aware that cause-specific mortality is a function of incidence and prognosis. He reasoned in potential outcome terms to estimate the reduced number of deaths from an intervention. He advanced a hypothesis of clinic overcrowding as a risk factor for puerperal sepsis mortality that turns out to be wrong. Semmelweis’ data provide a great pool for illustrating the logic of scientific discovery by use of the numerical method. The explanatory power of his work was strong and Semmelweis was able to refute several previous causal explanations.
Managing In-Company IT Standardization: A Design Theory
Authors: Ahlemann Frederik , Dittes Sven , Fillbrunn Tim , Rehring Kevin , Reining Stefan , Urbach Nils
Published: April 2022

Today’s companies rely heavily on in-company information technology standards (ICITS) to reduce costs, ensure flexibility, and facilitate the planning, implementation, and operation of IT systems. Steering and managing ICITS has proven to be challenging, revealing the need for efficient governance mechanisms. But even though prior research demonstrates the challenges of ICITS, viable advice on how to implement ICITS is scarce. In this paper, we develop an organizational design theory for the management of ICITS based on the framework of organizational control theory. We conducted a critical case study to identify basic goals, constitutive elements, and fundamental mechanisms of a working ICITS management. The resulting design goals and principles were then evaluated and further refined in the light of additional expert interviews. With our work, we wish to extend the body of theoretical knowledge on the management of ICITS and help practitioners master the various challenges occurring in this domain.
Listen to the Children: Elementary School Students' Perspectives on a Mindfulness Intervention
Authors: D’Alessandro Andrea M. , Butterfield Kaitlyn M. , Hanceroglu Lerna , Roberts Kim P.
Published: April 2022

In recent years, mindfulness-based practices in grade schools have been associated with students’ improved cognitive skills and general classroom behavior. In the majority of studies, however, only teacher and parent feedback are elicited, omitting a considerably significant voice – that of the students. Our study aims to fill this gap by exploring student opinions and perceptions regarding the implementation of a classroom-based mindfulness program. Elementary school students (N = 51) took part in teacher-facilitated mindfulness activities which were incorporated into their daily classroom routines. Over the course of the 8-week intervention period, students participated in focus groups about their perceptions of the program. Through qualitative content analysis, two major findings emerged from the focus group data: student opinions about the mindfulness program varied substantially and the mindfulness activities were not always liked and enjoyed. Critically, if students do not enjoy classroom-based mindfulness programs, they may be less motivated to engage in mindful activities and in turn may not experience the benefits that mindfulness has to offer. To maximize student engagement with mindfulness while addressing their concerns, the following recommendations are made: A balance between the entertaining and educational aspects of the program, flexible program delivery, and encouraging students to pursue mindful living outside of the classroom. This research is important to educational and clinical practitioners as student insight will benefit the development and modification of classroom-based mindfulness programs to ensure that students are better able to engage with and benefit from these programs.
The miR-183/96/182 cluster is upregulated in glioblastoma carrying EGFR amplification
Authors: Schneider Björn , William Doreen , Lamp Nora , Zimpfer Annette , Henker Christian , Classen Carl Friedrich , Erbersdobler Andreas
Published: April 2022

Glioblastoma (GBM) is one of the most frequent primary brain tumors. Limited therapeutic options and high recurrency rates lead to a dismal prognosis. One frequent, putative driver mutation is the genomic amplification of the oncogenic receptor tyrosine kinase EGFR. Often accompanied by variants like EGFRvIII, heterogenous expression and ligand independent signaling render this tumor subtype even more difficult to treat, as EGFR-directed therapeutics show only weak effects at best. So EGFR-amplified GBM is considered to have an even worse prognosis, and therefore, deeper understanding of molecular mechanisms and detection of potential targets for novel therapeutic strategies is urgently needed. In this study, we looked at the level of microRNAs (miRs), small non-coding RNAs frequently deregulated in cancer, both acting as oncogenes and tumor suppressors. Comparative analysis of GBM with and without EGFR amplification should give insight into the expression profiles of miRs, which are considered both as potential targets for directed therapies or as therapeutic reagents. Comparison of miR profiles of EGFR-amplified and EGFR-normal GBM revealed an upregulation of the miR-183/96/182 cluster, which is associated with oncogenic properties in several tumor entities. One prominent target of this miR cluster is FOXO1, a pro-apoptotic factor. By observing FOXO1 downregulation in EGFR-amplified tumors, we can see a significant correlation of EGFR amplification, miR-183/96/182 cluster upregulation, and repression of FOXO1. Although no significant difference in overall survival is shown, these data may contribute to the molecular understanding of this tumor subtype and offer potential targets for miR-based therapies.
AFD-Net: Apple Foliar Disease multi classification using deep learning on plant pathology dataset
Authors: Yadav Anju , Thakur Udit , Saxena Rahul , Pal Vipin , Bhateja Vikrant , Lin Jerry Chun-Wei
Published: April 2022

Background

Plant diseases significantly affect the crop, so their identification is very important. Correct identification of these diseases is crucial for establishing a good disease control strategy to avoid time and financial losses. In general, machines can greatly reduce the possibility of human error. In particular, computer vision techniques developed through deep learning have paved a way to detect and diagnose these plant diseases on the leaf.

Methods

In this work, the model AFD-Net was developed to detect and identify various leaf diseases in apple trees. The dataset is from Kaggle 2020 and 2021 and was financially supported by the Cornell Initiative for Digital Agriculture. An AFD-Net was proposed for leaf disease classification in apple trees and the results of the efficiency of the model are compared with other state-of-the-art deep learning approaches.

Results

The results of the experiments in the validation dataset show that the proposed AFD-Net model achieves the highest values of 98.7% accuracy for Plant Pathology 2020 and 92.6% for Plant Pathology 2021 compared to other deep learning models in the original and extended datasets.

Discussion

The results also indicate the efficiency of the proposed model in identifying leaf diseases on apple trees for major and minor classes, i.e., for multiple classification.
Influence of Classroom-Level Factors on Implementation Fidelity During Scale-up of Evidence-Based Interventions
Authors: Combs Katie Massey , Buckley Pamela R. , Lain Marion Amanda , Drewelow Karen M. , Urano Grace , Kerns Suzanne E. U.
Published: April 2022

As evidence-based interventions (EBIs) become more widely disseminated, fidelity of implementation (FOI) often wanes. This study explores the association between FOI and malleable variables within classrooms that could be targeted to optimize resources without compromising FOI as school-based EBIs are disseminated across real-world settings. We utilized process evaluation data from a national dissemination project of the Botvin LifeSkills Training (LST) middle school program, a universal prevention intervention shown to reduce substance use. The sample included 1,626 teachers in 371 schools across 14 states. Hierarchical linear models examined the relationship between observational measures of implementation factors and three domains of fidelity (e.g., adherence, student responsiveness, and quality of delivery). Findings suggest that curriculum modifications, student misbehavior, and shortage of time to implement the LST middle school program were factors most associated with lower FOI. Class size, access to program materials, and whether LST was delivered in a traditional classroom setting that is well-suited for instruction (versus in a less structured environment such as the school cafeteria) are less predictive. In scale-up of classroom-based universal interventions targeting behavioral health outcomes, our findings indicate that carefully vetting modifications, supporting classroom management strategies, and ensuring sufficient class time for implementation of highly interactive EBIs such as LST are important considerations. Since changes to EBIs are inevitable, efforts are needed to guide facilitators in making adjustments that improve program fit without compromising the essential intervention activities deemed necessary to produce desired outcomes.