bluuebunny/crossref_metadata_2025 huggingface dataset:
Fluoride-free and seed-free microwave-assisted hydrothermal synthesis of nanosized high-silica Beta zeolites for effective VOCs adsorption
Authors: Ma Zhe , Deng Hua , Li Lin , Zhang Qiang , Chen Guangrui , Sun Chang , He Hong , Yu Jihong
Published: January 2023

A facile fluoride-free and seed-free microwave-assisted hydrothermal strategy is developed to prepare nanosized pure-silica Beta zeolites for VOCs adsorption.
Oxalate metal–organic framework derived atomic Ru3+-doped Co(OH)2nanosheets for a highly efficient hydrogen evolution reaction
Authors: Zou Yizhong , Zhang Wen-Da , Hu Minghan , Zhang Zhe , Liu Jiangyong , Gu Zhi-Guo , Yan Xiaodong
Published: January 2023

Oxalate metal–organic framework derived atomic Ru3+-doped Co(OH)2nanosheets are fabricated for highly efficient hydrogen evolution reaction, showing a very small overpotential of 36 mV at 30 mA cm−2in 1.0 M KOH.
Construction of methylene-bridged electron-deficient corona[n]arenes and selective fluoride recognition through anion–π interactions
Authors: Guo Shen-Yi , Tong Shuo , Guo Qing-Hui , Wang Mei-Xiang
Published: January 2023

Despite significant development of the nascent anion–π interactions in recent years, the noncovalent interactions between fluoride ion, a unique anion species, and electron-neutral aromatic rings remain rare and even controversial.
The inhibition of ORMDL3 prevents Alzheimer's disease through ferroptosis by PERK/ATF4/HSPA5 pathway
Authors: Shao Yankun , Xu Yilin , Di Huang , Shi Xinxiu , Wang Yingying , Liu Hongyu , Song Lina
Published: January 2023

Alzheimer's disease (AD) is a neurodegenerative disease with high incidence and widespread attention. There is currently no clear clarification of the pathogenesis. However, ORMDL3 causes ferroptosis in AD, and the potential mechanisms remain unclear. So, this study explore the function of ORMDL3 on ferroptosis in AD and its potential regulatory mechanisms. APPswe/PS1dE9 mice and C57BL/6 mice were induced into the mice model. The murine microglial BV‐2 cells also were induced into the vitro model. In serum samples of AD patients, ORMDL3 mRNA expression levels were upregulated. The serum ORMDL3 levels expression was positively related to the ADL score or MoCA score in AD patients. The serum ORMDL3 expression level was positively related to MMSE score or Hcy levels in AD patients. The mRNA expression of ORMDL3 in the hippocampal tissue of the mice model of AD was upregulated at one, four and eight months. The protein expression of ORMDL3 was upregulated in the mice model of AD. ORMDL3 promoted Alzheimer's disease, and increased oxidative response and ferroptosis in a model of AD. PERK/ATF4/HSPA5 pathway is one important signal pathway for the effects of ORMDL3 in a model of AD. Collectively, these data suggested that ORMDL3 promoted oxidative response and ferroptosis in a model of AD by the PERK/ATF4/HSPA5 pathway, which might be a novel target spot mechanism of ferroptosis in AD and may serve as a regulator of AD‐induced ferroptosis.
A self-consistent hybrid model connects empirical and optical models for fast, non-destructive inline characterization of thin, porous silicon layers
Authors: Wörnhör Alexandra , Demant Matthias , Vahlman Henri , Rein Stefan
Published: January 2023

Epitaxially-grown wafers on top of sintered porous silicon are a material-efficient wafer production process, that is now being launched into mass production. This production process makes the material-expensive sawing procedure obsolete since the wafer can be easily detached from its seed substrate. With high-throughput inline production processes, fast and reliable evaluation processes are crucial. The quality of the porous layers plays an important role regarding a successful detachment. Therefore, we present a fast and non-destructive investigation algorithm of thin, porous silicon layers. We predict the layer parameters directly from inline reflectance data by using a convolutional neural network (CNN), which is inspired by a comprehensive optical modelling approach from literature. There, a numerical fitting approach on reflection curves calculated with a physical model is performed. By adding the physical model to the CNN, we create a hybrid model, that not only predicts layer parameters, but also recalculates reflection curves. This allows a consistency check for a self-supervised network optimization. Evaluation on experimental data shows a high similarity with Scanning Electron Microscopy (SEM) measurements. Since parallel computation is possible with the CNN, 30.000 samples can be evaluated in roughly 100 ms.
Acute periapical dental abscesses and increased risk for extracranial carotid artery aneurysms
Authors: Katz Joseph , Rotstein Ilan
Published: January 2023

Aim: To assess the prevalence of acute periapical abscesses (PAs) in patients with a history of extracranial carotid artery aneurysms (ECAA). Materials and methods: History of acute PAs and ECAA diagnosis was retrieved by searching the appropriate query in the database. All cases were diagnosed for acute PAs by calibrated dentists for patients admitted to urgent care. The odds ratio (OR) for the prevalence of acute PAs and its association with history of ECAA were then calculated. Results: The prevalence of acute PAs in patients with a history ECAA was significantly higher as compared to the general hospital patient population (p < 0.0001). The OR was 5.5. Females were more affected than males by 1.7 folds (p < 0.001). Whites were more affected than African Americans by 1.6 folds (p < 0.00001). Conclusions: The high prevalence of acute PAs in patients with a history of ECAA may suggest an association between these two conditions warranting a thorough medical examination.
Taille à l’âge adulte : une myriade de locus
Authors: Jordan Bertrand
Published: January 2023

The combination of 281 GWAS studies for adult height leads to the identification of 12,111 SNP in 7,209 loci that together account for essentially all SNP heritability for this trait: there is no longer any significant “missing heritability”, and these loci appear to be functionally relevant. This work is a model for future studies on the genetic determinants of complex diseases.
La signalisation de CXCR4, un rhéostat de la réponse immunitaire à médiation humorale
Authors: Khamyath Mélanie , Bonaud Amélie , Balabanian Karl , Espéli Marion
Published: January 2023

CXCR4 est un récepteur de chimiokine qui joue un rôle central dans la migration cellulaire mais également dans d’autres mécanismes essentiels, tels que le développement du système immunitaire. De concert avec son ligand naturel, la chimiokine CXCL12, cet axe de signalisation joue un rôle important dans la biologie des lymphocytes B, des stades précoces de différenciation dans la moelle osseuse à leur activation et différenciation en cellules sécrétrices d’anticorps, aussi appelées plasmocytes. Des mutations gain de fonction de CXCR4 sont retrouvées dans une immunodéficience rare, le Syndrome WHIM. Ces mutations affectent le mécanisme de désensibilisation du récepteur et entraînent un gain de fonction en réponse à CXCL12. Cette revue résume le rôle de CXCR4 dans la réponse immune humorale et, à travers l’étude du Syndrome WHIM, souligne le rôle régulateur essentiel de la désensibilisation de CXCR4 dans ces processus. Des travaux récents rapportent en effet qu’une signalisation correcte de CXCR4 est essentielle pour limiter la réponse immune dite « extra-folliculaire » et pour permettre une protection au long terme assurée par les anticorps.
Parcours médical et juridique transidentitaire
Authors: Denaes Béatrice
Published: January 2023

En France, la transidentité n’est plus considérée comme un « trouble mental » depuis 2010. Pour l’Organisation mondiale de la santé, il a fallu attendre 2022. La France est l’un des rares pays à prendre en charge la quasi-totalité du parcours de transition. Toutefois, cet arbre cache une jungle de textes et de cotations désormais obsolètes, de discriminations dans les prises en charge, de contraintes administratives et psychiatriques, de rejets transphobes. Officiellement, les seules recommandations concernant le parcours médical des personnes transgenres datent de 1989. Trente-quatre ans plus tard, la Haute autorité de santé entreprend une profonde remise en question des recommandations, aux côtés des médecins et des associations concernés par la santé des personnes trans.
Transition des patients atteints d’une maladie respiratoire chronique depuis la pédiatrie vers les services pour adultes
Authors: Mittaine Marie , Roditis Léa , Dupuis Marion
Published: January 2023

Du fait de l’augmentation de l’espérance de vie des individus atteints de mucoviscidose, la transition de la pédiatrie vers les services de médecine pour adultes est devenue une étape essentielle pour les patients, les aidants et les soignants. Cette transition doit être progressive et longuement préparée. Avoir un processus établi et formalisé, aborder tôt le thème de la transition avec le patient et sa famille, autonomiser le patient avant le transfert et établir des liens étroits entre les structures médicales pédiatriques et pour adultes sont des éléments importants pour la réussite de cette étape. L’éducation thérapeutique ainsi que l’utilisation de questionnaires validés, d’un plan d’action personnalisé ou d’outils connectés peuvent aider. Le transfert se fera au moment le mieux adapté pour le patient, idéalement en période de stabilité de la maladie, de manière progressive, avec des consultations conjointes ou alternées entre les équipes de pédiatrie et de médecine pour adultes. D’autres maladies respiratoires chroniques débutant dans l’enfance ou à l’adolescence pourront bénéficier d’un processus de transition similaire.
La Force d’action rapide du nucléaire continue d’évoluer
Authors: Le Gros Gaïc
Published: January 2023

La Force d’action rapide du nucléaire (Farn) est une unité unique au monde conçue pour faire face à l’inimaginable. Cette force composée d’un peu plus de 300 personnes peut intervenir sur n’importe quelle centrale nucléaire française en moins de 24 heures.
Canicule 2022 : les enjeux liés à l’eau pour le fonctionnement du nucléaire
Authors: Hanine Ilyas
Published: January 2023

Pour continuer à produire de l’électricité alors que les conditions climatiques de cet été 2022 ont été extrêmes (chaleur et sécheresse), les limites thermiques liées aux rejets de certaines centrales ont été relevées temporairement à quatre reprises par arrêté. EDF a alors dû procéder à un bilan environnemental de l’impact du fonctionnement des centrales concernées, conformément à la réglementation.
Vielseitigkeit in Neurologie und Psychiatrie
Authors: Falkai Peter
Published: January 2023

Liebe Kolleginnen, liebe Kollegen,

beide Disziplinen, sowohl die Neurologie als auch die Psychiatrie konnten ihr Wissen
in den von ihnen behandelten Erkrankungen in den letzten Jahren weiterhin deutlich
erweitern, ebenso wie sich diagnostische und therapeutische Verfahren und ihre
Langzeitprognosen stetig verbessert haben. Diese erste Ausgabe der
Fortschritte spiegelt einmal wieder die Breite der in den Fachbereichen
Neurologie und Psychiatrie behandelten Themen.
Applications of Gene Therapy in Dentistry: A Review Article
Authors: Nair Karthika , Bhat Amitha Ramesh
Published: January 2023

Gene therapy promises to possess a good prospect in bridging the gap between dental applications and medicine. The dynamic therapeutic modalities of gene therapy have been advancing rapidly. Conventional approaches are being revamped to be more comprehensive and pre-emptive, which could do away with the need for surgery and medicine altogether. The complementary base sequences known as genes convey the instructions required to manufacture proteins. The oral cavity is one of the most accessible locations for the therapeutic intervention of gene therapy for several oral tissues. In 1990, the first significant trial of gene therapy was overseen to alleviate adenosine deaminase deficiency. The notion of genetic engineering has become increasingly appealing as a reflection of its benefits over conventional treatment modalities. An example of how this technology may alter dentistry is the implementation of gene therapy for dental and oral ailments. The objective of this article is to examine the effects of gene therapy on the field of dentistry, periodontology and implantology. Furthermore, the therapeutic factors of disease therapy, minimal invasion, and appropriate outcome have indeed been taken into consideration.
Medial Femoral Condyle Corticoperiosteal Flap for Failed Total Wrist Fusions
Authors: Tee Richard , Harvey Jason N. , Tham Stephen K. , Ek Eugene T.
Published: January 2023

Background Recalcitrant nonunion following total wrist arthrodesis is a rare but challenging problem. Most commonly, in the setting of failed fusion after multiple attempts of refixation and cancellous bone grafting, the underlying cause for the failure is invariably multifactorial and is often associated with a range of host issues in addition to poor local soft-tissue and bony vascularity. The vascularized medial femoral condyle corticoperiosteal (MFC-CP) flap has been shown to be a viable option in a variety of similar settings, which provides vascularity and rich osteogenic progenitor cells to a nonunion site, with relatively low morbidity. While its utility has been described for many other anatomical locations throughout the body, its use for the treatment of failed total wrist fusions has not been previously described in detail in the literature.

Methods In this article, we outline in detail the surgical technique for MFC-CP flap for the management of recalcitrant aseptic nonunions following failed total wrist arthrodesis. We discuss indications and contraindications, pearls and pitfalls, and potential complications of this technique.

Results Two illustrative cases are presented of patients with recalcitrant nonunions following multiple failed total wrist fusions.

Conclusion When all avenues have been exhausted, a free vascularized corticoperiosteal flap from the MFC is a sound alternative solution to achieve union, especially when biological healing has been compromised. We have been able to achieve good clinical outcomes and reliable fusion in this difficult patient population.
Cryo-EM structure of the whole photosynthetic reaction center apparatus from the green sulfur bacterium
Chlorobaculum tepidum
Authors: Xie Hao , Lyratzakis Alexandros , Khera Radhika , Koutantou Myrto , Welsch Sonja , Michel Hartmut , Tsiotis Georgios
Published: January 2023

Light energy absorption and transfer are very important processes in photosynthesis. In green sulfur bacteria light is absorbed primarily by the chlorosomes and its energy is transferred via the Fenna–Matthews–Olson (FMO) proteins to a homodimeric reaction center (RC). Here, we report the cryogenic electron microscopic structure of the intact FMO-RC apparatus from
Chlorobaculum tepidum
at 2.5 Å resolution. The FMO-RC apparatus presents an asymmetric architecture and contains two FMO trimers that show different interaction patterns with the RC core. Furthermore, the two permanently bound transmembrane subunits PscC, which donate electrons to the special pair, interact only with the two large PscA subunits. This structure fills an important gap in our understanding of the transfer of energy from antenna to the electron transport chain of this RC and the transfer of electrons from reduced sulfur compounds to the special pair.
Designing speaking tasks for different assessment goals
Authors: Sasayama Shoko , Norris John M.
Published: January 2023

This study explored the role of cognitive task complexity in designing speaking assessment tasks. A sample of 120 English learners at different proficiency levels engaged in four narrative tasks with distinct levels/types of cognitive complexity. Performances were assessed using linguistic measures and a task accomplishment rubric. Findings revealed that one of the middle-complexity tasks with moderate intrinsic, moderate germane, and low extraneous complexity elicited the best linguistic performances overall, while the lowest complexity task elicited the highest task accomplishment ratings. Focusing on distinguishing among learner abilities, however, the highest complexity task demonstrated the best discrimination. Cognitive task complexity was also found to moderate the relationship between task accomplishment ratings and linguistic measures. Implications for research into task design, learner performance, and assessment purpose are considered.
Experimental investigations of influence on grain size and cold deformational behavior of AL6063 during the microforming process
Authors: Karthikeyan A , Rajenthirakumar D
Published: January 2023

Miniature products are requisite to make micro creation widely in electronics and micromechanical products. The microfabrication process is identified to satisfy the production of such miniature products rather than an ordinary manufacturing process. Microextrusion is one of the microforming processes in micromanufacturing. In this present work, an attempt has been made to investigate the influence of grain size and deformation behavior of Al6063 microstepped pin with annealed billets for the cold extrusion process. The methodology on the characterization of the microextrusion of Al6063 includes, annealing of the billet, extrusion testing, microhardness examination and surface roughness analysis. The billet with three different sizes of grains is extruded. The experimental result shows that the deformation load and average microhardness of the AA96 (annealed Al6063 with an obtained grain size of 96 μm) are high compared to AA208 (annealed Al6063 with an obtained grain size of 208 μm). The surface finish has improved using diamond-like carbon (DLC) coated die compared to uncoated and lubricated dies. DLC coating with AA208 billet achieved a maximum pin length of 13.1 mm, and uncoated die with AA96 billet achieved a minimum pin length of 5.5 mm. Thus, the findings of this study contribute to the fundamental understanding of cold microextrusion of aluminium 6063 alloy.
Methane emissions decline from reduced oil, natural gas, and refinery production during COVID-19
Authors: Thorpe A K , Kort E A , Cusworth D H , Ayasse A K , Bue B D , Yadav V , Thompson D R , Frankenberg C , Herner J , Falk M , Green R O , Miller C E , Duren R M
Published: January 2023

In the summer of 2020, the AVIRIS-NG airborne imaging spectrometer surveyed California’s Southern San Joaquin Valley and the South Bay (Los Angeles County) to identify anthropogenic methane (CH4) point source plumes, estimate emission rates, and attribute sources to both facilities and emission sectors. These flights were designed to revisit regions previously surveyed by the 2016–2017 California Methane Survey and to assess the socioeconomic responses of COVID-19 on emissions across multiple sectors. For regions flown by both the California Methane Survey and the California COVID campaigns, total CH4 point source emissions from the energy and oil & natural gas sectors were 34.8% lower during the summer 2020 flights, however, emission trends varied across sector. For the energy sector, there was a 28.2% decrease driven by reductions in refinery emissions consistent with a drop in production, which was offset in part with increases from powerplants. For the oil & natural gas sector, CH4 emissions declined 34.2% and significant variability was observed at the oilfield scale. Emissions declined for all but the Buena Vista and Cymric fields with an observed positive relationship between production and emissions. In addition to characterizing the short-term impact of COVID-19 on CH4 emissions, this study demonstrates the broader potential of remote sensing with sufficient sensitivity, spatial resolution, and spatio-temporal completeness to quantify changes in CH4 emissions at the scale of key sectors and facilities.
Analytic ranks of elliptic curves over number fields
Authors: Cho Peter
Published: January 2023

Let

E
E

be an elliptic curve over

Q

\mathbb {Q}

. Then, we show that the average analytic rank of

E
E

over cyclic extensions of degree

l
l

over

Q

\mathbb {Q}

with

l
l

a prime not equal to

2
2

, is at most

2
+

r

Q

(
E
)

2+r_\mathbb {Q}(E)

, where

r

Q

(
E
)

r_\mathbb {Q}(E)

is the analytic rank of the elliptic curve

E
E

over

Q

\mathbb {Q}

. This bound is independent of the degree

l
l

. Using a recent result of Bhargava, Taniguchi and Thorne [Improved error estimates for the Davenport–Heilbronn theorems, arxiv.org/abs/2107.12819, 2021], we obtain a non-trivial upper bound on the average analytic rank of

E
E

over

S
3

S_3

-fields.
Lyapunov exponents for non-ergodic meromorphic functions
Authors: Kotus Janina , Montes de Oca Balderas Marco
Published: January 2023

Levin, Przytycki and Shen [Invent. Math. 205 (2016), pp. 363–382] proved for a polynomial map

f
c

(
z
)
=

z
d

+
c

f_c(z)=z^d+c

,

d
≥
2

d\geq 2

and

c
∈

C

c \in \mathbb C

, with Julia set

J
(
f
)

J(f)

of positive measure that for a.e.

z
∈
J
(
f
)

z \in J(f)

the Lyapunov exponent

χ
s

(
z
)
=
0

\chi _s(z)=0

. The aim of this paper is to show that the extension to non-entire transcendental meromorphic functions is not possible.
Evaluation of the impact of a pharmacist-run antimicrobial report in reducing delays in subsequent antibiotic administration in patients in the emergency department
Authors: Moynihan Meghin , Anton Greta
Published: January 2023

Purpose

To determine whether the implementation of a pharmacist-run, real-time electronic health record (EHR) antimicrobial report reduces the frequency of delays in subsequent antibiotic medication administration timing in patients in the emergency department (ED).

Methods

A single-center, retrospective, pre-and-post quasi-experimental study was conducted between July and December 2021 following the implementation of an antimicrobial EHR report of adult patients presenting to the ED who were continued on antibiotic therapy after receiving a one-time dose of an antibiotic in the ED. The primary objective was to determine the impact of the pharmacist-run, real-time EHR antibiotic dosing report in the ED on reducing the number of major delays in subsequent antibiotic administration times. A subanalysis of the primary outcome was performed to evaluate differences in major delays based on specific dosing intervals of 6, 8, and 12 hours.

Results

A total of 521 subsequent antibiotic dosing orders from 273 patient encounters were analyzed, with major delays in subsequent antibiotic dosing administration times identified in 20% of the intervention group compared to 27% of the control group (P = 0.047). Major delays were also significantly decreased in the intervention group compared to the control group for antibiotics dosed at 8-hour intervals (18% vs 32%; P = 0.026). No significant difference in delays was observed between the groups for antibiotics dosed at 6-hour intervals (18% vs 27%) or 12-hour intervals (29% vs 21%).

Conclusion

Implementing a real-time EHR antimicrobial report run by pharmacists in the ED was associated with significantly fewer major delays in subsequent antibiotic dosing following a first dose.
Hyper-Hamiltonian Laceability of Cartesian Products of Cycles and Paths
Authors: Yang Yuxing
Published: January 2023

Let $H$ be a cartesian product graph of even cycles and paths, where the first multiplier is an even cycle of length at least $4$ and the second multiplier is a path with at least two nodes or an even cycle. Then $H$ is an equitable bipartite graph, which takes the torus, the column-torus and the even $k$-ary $n$-cube as its special cases. For any node $w$ of $H$ and any two different nodes $u$ and $v$ in the partite set of $H$ not containing $w$, an algorithm was introduced to construct a hamiltonian path connecting $u$ and $v$ in $H-w$.
Atlantic salmon (Salmo salar) age at maturity is strongly affected by temperature, population and age-at-maturity genotype
Authors: Åsheim Eirik R , Debes Paul V , House Andrew , Liljeström Petra , Niemelä Petri T , Siren Jukka P , Erkinaro Jaakko , Primmer Craig R
Published: January 2023

Age at maturity is a key life history trait involving a trade-off between survival risk and reproductive investment, and is an important factor for population structures. In ectotherms, a warming environment may have a dramatic influence on development and life history, but this influence may differ between populations. While an increasing number of studies have examined population-dependent reactions with temperature, few have investigated this in the context of maturation timing. Atlantic salmon, a species of high conservation relevance, is a good study species for this topic as it displays considerable variation in age at maturity, of which a large proportion has been associated with a genomic region including the strong candidate gene vgll3. Until now, the effect of this gene in the context of different environments and populations has not been studied. Using a large-scale common-garden experiment, we find strong effects of temperature, population-of-origin, and vgll3 genotype on maturation in 2-year-old male Atlantic salmon (Salmo salar). With a temperature difference of 1.8°C, maturation probability was 4.8 times higher in the warm treatment than the cold treatment. This temperature effect was population-specific and was higher in the southern (60.48°N) compared to the northern (65.01°N) population. The early maturation vgll3*E allele was associated with a significantly higher maturation probability, but there was no vgll3 interaction with temperature or population. Both body condition and body mass associated with maturation. The body mass association was only present in the warm treatment. Our findings demonstrate that (i) populations can vary in their response to temperature change in terms of age at maturity, (ii) high intrinsic growth could be associated with higher thermal sensitivity for life history variation and (iii) vgll3 effects on age at maturity might be similar between populations and different thermal environments.
Impact of intra-aortic balloon counterpulsation on all-cause mortality among patients with Takotsubo syndrome complicated by cardiogenic shock: results from the German-Italian-Spanish (GEIST) registry
Authors: Santoro Francesco , Núñez Gil Iván J , Stiermaier Thomas , El-Battrawy Ibrahim , Moeller Christian , Guerra Federico , Novo Giuseppina , Arcari Luca , Musumeci Beatrice , Cacciotti Luca , Mariano Enrica , Romeo Francesco , Cannone Michele , Caldarola Pasquale , Giannini Irene , Mallardi Adriana , Leopizzi Alessandra , Vitale Enrica , Montisci Roberta , Meloni Luigi , Raimondo Pasquale , Di Biase Matteo , Almendro-Delia Manuel , Sionis Alessandro , Uribarri Aitor , Akin Ibrahim , Thiele Holger , Eitel Ingo , Brunetti Natale Daniele
Published: January 2023

Aims

Takotsubo syndrome (TTS) is an acute and reversible left ventricular dysfunction and can be complicated by cardiogenic shock (CS). However, few data are available on optimal care in TTS complicated by CS. Aim of this study was to evaluate short- and long-term impact of intra-aortic balloon pumping (IABP) on mortality in this setting.

Methods and results

In a multi-centre, international registry on TTS, 2248 consecutive patients were enrolled from 38 centres from Germany, Italy, and Spain. Of the 2248 patients, 212 (9.4%) experienced CS. Patients with CS had a higher prevalence of diabetes (27% vs. 19%), male sex (25% vs. 10%), and right ventricular involvement (10% vs. 5%) (P < 0.01 in all cases). Forty-three patients with CS (20% of 212) received IABP within 8 h (interquartile range 4–18) after admission. No differences in terms of age, gender, cardiovascular risk factors, and admission left ventricular ejection fraction were found among patients with and without IABP. There were no significant differences in terms of 30-day mortality (16% vs. 17%, P = 0.98), length of hospitalization (18.9 vs. 16.7 days, P = 0.51), and need of invasive ventilation (35% vs. 41%, P = 0.60) among two groups: 30-day survival was not significantly different even after propensity score adjustment (log-rank P = 0.73). At 42-month follow-up, overall mortality in patients with CS and TTS was 35%, not significantly different between patients receiving IABP and not (37% vs. 35%, P = 0.72).

Conclusions

In a large multi-centre observational registry, the use of IABP was not associated with lower mortality rates at short- and long-term follow-up in patients with TTS and CS.
Beyond exercise oscillatory ventilations: the prognostic impact of loop gain in heart failure
Authors: Cunha Gonçalo J L , Maltês Sérgio , Rocha Bruno M L , Nina Duarte , Aguiar Carlos , Andrade Maria J , Moreno Luís , Durazzo Anaí , Mendes Miguel , Agostoni Piergiuseppe
Published: January 2023

Exercise oscillatory ventilation (EOV) is a strong prognostic marker in patients with heart failure (HF) and left ventricular (LV) dysfunction. This phenomenon can be explained through a single quantitative measurement of ventilatory instability, the loop gain. Therefore, we aimed to evaluate whether loop gain could be a better tool than subjective EOV evaluation to identify HF patients with a higher risk of major cardiovascular complications. This was a single-center retrospective study that included patients with left ventricular ejection fraction (LVEF) ≤ 50% consecutively referred for cardiopulmonary exercise testing (CPET) from 2016 to 2020. Loop gain was measured through computational evaluation of the minute ventilation graph. Of the 250 patients included, the 66 that presented EOV also had higher values of loop gain, when compared with patients without EOV. Those with both EOV and higher loop gain had more severe HF, with higher NT-proBNP and VE/VCO2 slope as well as lower peak VO2 and LVEF. On multivariable analysis, loop gain was strongly correlated with the composite endpoint of cardiovascular death, urgent heart transplantation, urgent left ventricular assist device implantation, or HF hospitalization, even after correcting for peak VO2, LVEF, VE/VCO2 slope, and NT-proBNP. The presence of EOV was not prognostically significant in this analysis. Loop gain is an objective parameter that quantifies ventilatory instability and showed to have a strong prognostic value in a cohort of patients with HF and LVEF ≤50%, outperforming the classification of EOV.
The Neutralisation Doctrine in EU Trade Mark Law: A Plea for Its Abolishment
Authors: Vrielink Jesper , Torenbosch Jorn
Published: January 2023

This article focuses on the neutralisation doctrine established by the Court of Justice of the European Union in its Picasso/Picaro ruling. This doctrine stipulates that visual and/or phonetic similarity of conflicting signs can be neutralised by a conceptual difference between the signs if one of those signs has a clear and specific meaning which can be grasped immediately by the public. We trace the origin of the neutralisation doctrine as well as the manner in which the neutralisation doctrine has developed over the years. We then assess the position of the neutralisation doctrine in the broader phased assessment of similarity established by the Court of Justice of the European Union in EUIPO/Equivalenza Manufactory. We express our objections against the neutralisation doctrine and argue for its abolishment. In our view, the test of whether the public perceives a sign as referring to a trade mark which identifies goods or services or as a word or famous person is in essence a test of the distinctive character of that sign. In our concluding remarks, we argue once more for the abolishment of the neutralisation doctrine and provide some practical guidance to minimise its effects as long as it remains established law.
To say almost the same thing? A study on cross-linguistic variation in ancient texts and their translations
Authors: Palladino Chiara , Yousef Tariq
Published: January 2023

This article presents a study of several parallel corpora of historical languages and their translations. The aligned corpora are the result of a large crowdsourcing project, named Ugarit, aimed at supporting translation alignment for ancient and historical languages: the study of the resulting translation pairs allows us to observe cross-linguistic dynamics in a range of languages, some of which have never been systematically aligned before. The corpora considered are divided into two distinct groups: English translations of ancient languages, including Greek, Latin, Persian, and Coptic; and translations of ancient Greek into other languages, including Latin, English, Georgian, Italian, and Persian. We evaluated different ratios of word matching across each language pair (one-to-one, one-to-many, many-to-one, and many-to-many), and analyzed the resulting trends across the corpus. We propose some observations on how and why different types of alignment links are established in a given language pair, and what factors affect their creation beyond the control of the user: we propose two complementary hypotheses to explain the changes, one based on structural linguistic factors and the other based on cultural difference.
Evolutionary dynamics of respiratory syncytial virus in Buenos Aires: Viral diversity, migration, and subgroup replacement
Authors: Goya Stephanie , Lucion Maria Florencia , Shilts Meghan H , Juárez María del Valle , Gentile Angela , Mistchenko Alicia S , Viegas Mariana , Das Suman R
Published: January 2023

Globally, the human respiratory syncytial virus (RSV) is one of the major causes of lower respiratory tract infections (LRTIs) in children. The scarcity of complete genome data limits our understanding of RSV spatiotemporal distribution, evolution, and viral variant emergence. Nasopharyngeal samples collected from hospitalized pediatric patients from Buenos Aires tested positive for RSV LRTI during four consecutive outbreaks (2014–2017) were randomly subsampled for RSV complete genome sequencing. Phylodynamic studies and viral population characterization of genomic variability, diversity, and migration of viruses to and from Argentina during the study period were performed. Our sequencing effort resulted in one of the largest collections of RSV genomes from a given location (141 RSV-A and 135 RSV-B) published so far. RSV-B was dominant during the 2014–2016 outbreaks (60 per cent of cases) but was abruptly replaced by RSV-A in 2017, with RSV-A accounting for 90 per cent of sequenced samples. A significant decrease in RSV genomic diversity—represented by both a reduction in genetic lineages detected and the predominance of viral variants defined by signature amino acids—was observed in Buenos Aires in 2016, the year prior to the RSV subgroup predominance replacement. Multiple introductions to Buenos Aires were detected, some with persistent detection over seasons, and also, RSV was observed to migrate from Buenos Aires to other countries. Our results suggest that the decrease in viral diversity may have allowed the dramatic predominance switch from RSV-B to RSV-A in 2017. The immune pressure generated against circulating viruses with limited diversity during a given outbreak may have created a fertile ground for an antigenically divergent RSV variant to be introduced and successfully spread in the subsequent outbreak. Overall, our RSV genomic analysis of intra- and inter-outbreak diversity provides an opportunity to better understand the epochal evolutionary dynamics of RSV.
Long-term clinical outcomes of patients with COVID-19 and chronic liver disease: US multicenter COLD study
Authors: Aby Elizabeth S. , Moafa Ghady , Latt Nyan , Sultan Mohammad T. , Cacioppo Paula A. , Kumar Sonal , Chung Raymond T. , Bloom Patricia P. , Gustafson Jenna , Daidone Michael , Reinus Zoe , Debes Jose D. , Sandhu Sunny , Sohal Aalam , Khalid Sameeha , Roytman Marina , Catana Andreea Maria , Wegermann Kara , Carr Rotonya M. , Saiman Yedidya , Kassab Ihab , Chen Vincent L. , Rabiee Atoosa , Rosenberg Carly , Nguyen Veronica , Gainey Christina , Zhou Kali , Chavin Kenneth , Lizaola-Mayo Blanca C. , Chascsa David M. , Varelas Lee , Moghe Akshata , Dhanasekaran Renumathy
Published: January 2023

Background:

COVID-19 is associated with higher morbidity and mortality in patients with chronic liver diseases (CLDs). However, our understanding of the long-term outcomes of COVID-19 in patients with CLD is limited.

Methods:

We conducted a multicenter, observational cohort study of adult patients with CLD who were diagnosed with COVID-19 before May 30, 2020, to determine long-term clinical outcomes. We used a control group of patients with CLD confirmed negative for COVID-19.

Results:

We followed 666 patients with CLD (median age 58 years, 52.8% male) for a median of 384 (interquartile range: 31–462) days. The long-term mortality was 8.1%; with 3.6% experiencing delayed COVID-19-related mortality. Compared to a propensity-matched control group of patients with CLD without COVID-19 (n=1332), patients with CLD with COVID-19 had worse long-term survival [p<0.001; hazards ratio (HR): 1.69; 95% CI: 1.19–2.41] and higher rate of hospitalization (p<0.001, HR: 2.00, 1.62–2.48) over a 1-year follow-up period. Overall, 29.9% of patients reported symptoms of long-COVID-19. On multivariable analysis, female sex (p=0.05, HR: 2.45, 1.01–2.11), Hispanic ethnicity (p=0.003, HR: 1.94, 1.26–2.99), and severe COVID-19 requiring mechanical ventilation (p=0.028, HR: 1.74, 1.06–2.86) predicted long-COVID-19. In survivors, liver-related laboratory parameters showed significant improvement after COVID-19 resolution. COVID-19 vaccine status was available for 72% (n=470) of patients with CLD and history of COVID-19, of whom, 70% (n=326) had received the COVID-19 vaccine.

Conclusions:

Our large, longitudinal, multicenter study demonstrates a high burden of long-term mortality and morbidity in patients with CLD and COVID-19. Symptoms consistent with long-COVID-19 were present in 30% of patients with CLD. These results illustrate the prolonged implications of COVID-19 both for recovering patients and for health care systems.
Early Postural Stability Changes in Patients Undergoing Correction of Spinal Deformity
Authors: Keister Alexander , Grossbach Andrew , Toop Nathaniel , Mallory Noah , Gibbs David , Xu David , Viljoen Stephanus
Published: January 2023

Background Context.

Adult spinal deformity (ASD) is a prevalent condition often requiring surgical intervention. Improved outcomes among ASD patients have been shown to correlate with postoperative spinopelvic parameters, yet little is currently known about the role of postural stability and balance assessment for ASD patients.

Purpose.

Explore early changes in postural stability following ASD correction.

Study Design.

Prospective cohort study.

Patient Sample.

Sixteen adult patients who underwent four-level or greater posterolateral fusion to address global spinal malalignment and 14 healthy controls with no known spinal deformity nor surgery.

Outcome Measures.

Postural stability parameters, spinopelvic parameters preoperatively and postoperatively.

Methods.

Force plate balance assessment was completed where participants and healthy controls were instructed to stand with their hands at their sides, standing still, with eyes open. Center of pressure (COP), center of gravity (COG), and cone of economy (COE) parameters were analyzed with paired and unpaired t tests with an alpha of 0.05.

Results.

Preoperatively, ASD patients demonstrated more COG (P=0.0244) and sagittal and coronal head (P<0.05) sway than healthy controls. Postoperatively, ASD patients exhibited less COP (P=0.0308), COG (P=0.0276) and head (P=0.0345) sway. Compared to healthy controls, ASD patients postoperatively exhibited similar postural stability, aside from COP and COG sway amplitudes (P<0.05), and coronal head sway (P=0.0309). Pelvic incidence-lumbar lordosis and sagittal vertical axis improved from 16.2° to 4.8° (P<0.01) and 82.2 to 22.5 mm (P<0.01), respectively.

Conclusion.

We report a novel early improvement in postural stability, comparable to healthy controls, following ASD correction that may be related to improved spinopelvic alignment. Force plate evaluation may be a useful tool for ASD patients postoperatively. Future clinical trials assessing the impact of postural stability on clinical and radiographic outcomes are warranted.
A Combined Scoring Method Based on 18F-FDG PET/CT for Distinguishing Spinal Infection From Malignancy
Authors: Chen Jing , Xue Lingyu , Li Xinlei , Xiong Wei
Published: January 2023

Study Design.

Retrospective study.

Objective.

This study aimed to explore the additional value of fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) for the detection of early-stage and atypical spinal infections and to find the best combination of indicators from laboratory and imaging systems for higher diagnostic efficiency.

Summary of Background Data.

Diagnosis of early-stage and atypical spinal infections may be challenging for clinicians. It is particularly important to distinguish spinal infection from malignancy to develop a timely treatment strategy and avoid unnecessary biopsy or surgery.

Materials and Methods.

All patients with a discharge diagnosis of spinal infection or malignancy who underwent 18F-FDG PET/CT scans before spinal biopsy between January 1, 2014, and July 30, 2021, were included. Laboratory and imaging data were assessed. A receiver operating characteristic (ROC) curve was created, and the best cut-off point and cumulated area under the curve (AUC) were obtained to distinguish between spinal infection and malignancy. Kappa values were used to assess the agreement between the 18F-FDG PET/CT and MRI findings. Binary logistic regression was used to screen for statistically significant indicators and imaging findings.

Results.

A total of 71 patients with confirmed spinal infections (n=30) or malignancies (n=41) were included in this study. Elevated ESR and significantly elevated tumor biomarkers or positive FLCs assay were significantly different between the two groups. In addition to the total lesion glycolysis of the involved vertebral bodies derived from 18F-FDG PET/CT, four imaging findings (consecutive multilevel vertebral lesions, intervertebral disc, vertebral arch, and extraspinal involvement) also showed significant differences between the two groups (P≤0.010). A combined scoring method based on the above seven indicators was designed with an overall classification accuracy of 95.2%, and it identified all patients with spinal infections (100%, 28/28). In addition, moderate-to-excellent agreement could be reached for the involvement of intervertebral discs, paravertebral soft tissues, and vertebral arches derived from MRI and18F-FDG PET/CT.

Conclusions.

The combined scoring method based on 18F-FDG PET/CT provided excellent overall accuracy in distinguishing spinal infections from malignancies. This approach may prove useful for patients with MRI contraindications or with equivocal results following laboratory tests or traditional imaging when there is high suspicion for spinal infections or malignancy.
BAP1-Inactivated Melanoma Arising From BAP1-Inactivated Melanocytic Tumor in a Patient With BAP1 Germline Mutation: A Case Report and Review of the Literature
Authors: Donati Michele , Šteiner Petr , Kazakov Dmitry V.
Published: January 2023

BAP1-inactivated melanocytic tumors represent a subset of epithelioid melanocytic neoplasms resulting from biallelic inactivation of the BAP1 gene and by a driver mutation that activate the MAP kinase pathway, most commonly BRAF

V600E
. They occur sporadically or, less common, in the setting of BAP1 tumor predisposition syndrome caused by a BAP1 germline mutation that predisposes to several malignancies including cutaneous and uveal melanoma. To date, only few cases of BAP1-inactivated melanomas have been reported. We present a case of a 35-year-old woman presented with a melanocytic lesion microscopically composed of 3 distinct melanocytic populations, suggesting a stepwise progression model to melanoma from a conventional nevus through a melanocytoma stage. This progression was also supported from a molecular viewpoint given BRAF

V600E
, BAP1, and TERT-p hot spot mutations detected by targeted mutational analysis. Four atypical melanocytic lesions were removed from the patient's back, and the same A BAP1 c.856A>T, p.(Lys286Ter) mutation was detected on either tumoral or normal tissue samples. To the best of our knowledge, this is the first case of BAP1-inactivated melanoma with a documented TERT-p hot spot mutation manifesting as the first presentation of BAP1 tumor predisposition syndrome.
Recurrent Neuroendocrine Primary Cutaneous Mucinous Carcinoma of the Scalp After Complete Excision
Authors: Levett Kaitlyn , Taylor Brandon , Krishnan Bhuvaneswari , Ramani Nisha S.
Published: January 2023

Primary cutaneous mucinous carcinoma is a rare, indolent malignancy with a debated history regarding cell of origin. Recurrence is rare but has been documented in up to a third of cases. Recent literature reviews have recognized 2 possible subtypes—neuroendocrine and nonneuroendocrine— with different possible prognostic implications for patients. We describe a case of recurrent primary cutaneous mucinous carcinoma in a 50-year-old man with subtle neuroendocrine features not initially recognized on routine H&E staining but highlighted by immunohistochemical studies. We underscore the importance of immunohistochemical use in these rare cases and emphasize that awareness of these neuroendocrine and nonneuroendocrine subtypes is essential for a complete diagnosis.
Using Hospital Incident Command Systems to Respond to the Pediatric Mental and Behavioral Health Crisis of the COVID-19 Pandemic
Authors: Westley Laura , Manworren Renee C.B. , Griffith Debrea M. , Hoffmann Jennifer A. , Janssen Aron , Routburg Susan , Richey Karen
Published: January 2023

Hospital incident command systems (HICS) were implemented to expand mental and behavioral healthcare (MBHC) services during the COVID-19 pandemic. Data on patient census, nurse vacancies, staff injuries, and staff perceptions were analyzed to quantify issues and track progress toward HICS goals. Data, environment of care, staffing, staff support, staff education, and communication resources were developed. After HICS implementation, 84% of nurses reported confidence in providing care to youth with acute MBHC needs. Nurse leaders should consider HICS for addressing other crises.
Molecular Testing for Diagnostics, Prognostication, and Treatment Stratification in Cancers
Authors: Heneidi Saleh , Golden Jeffrey A. , Vail Eric
Published: January 2023

Precision cancer care, for essentially all cancer types, now requires molecular diagnostics to assess mutations, chromosomal alterations, and gene expression to personalize treatments for individual patients. Advances in the diagnostics and treatment options have moved the field forward from fundamental discoveries beginning in the 1960s to the development of many targeted therapies that can be as specific as targeting a single-base-pair mutation. Herein is a brief historical perspective on cancer precision medicine with current diagnostic, prognostic, and treatment stratification guidance for early- and late-stage cancers.
177Lu-rhPSMA-10.1 Induces Tumor Response in a Patient With mCRPC After PSMA-Directed Radioligand Therapy With 177Lu-PSMA-I&T
Authors: Bundschuh Ralph A. , Pfob Christian H. , Wienand Georgine , Dierks Alexander , Kircher Malte , Lapa Constantin
Published: January 2023

177Lu-rhPSMA-10.1 is a novel PSMA-targeting radiopharmaceutical that has been optimized in terms of pharmacological and pharmacokinetic properties and may be therefore advantageous in treatment of metastatic castrate-resistant prostate cancer. In this image, we present the case of an 86-year-old man with metastastic castrate-resistant prostate cancer undergoing 177Lu-PSMA-I&T treatment. After initial partial response to radioligand therapy, another 2 treatment cycles resulted in a rising serum PSA level that could be correlated with increasingly PSMA-positive as well as a new bone lesion. Consequently, the patient was changed to 177Lu-rhPSMA-10.1 treatment on a compassionate use basis achieving a renewed tumor response.