bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Cognitive Resource Competition Due to Dual-Tasking on the Irregularity and Control of Postural Movement Components
Authors: Haid Thomas , Federolf Peter
Published: January 2019

Postural control research suggests a non-linear, n-shaped relationship between dual-tasking and postural stability. Nevertheless, the extent of this relationship remains unclear. Since kinematic principal component analysis has offered novel approaches to study the control of movement components (PM) and n-shapes have been found in measures of sway irregularity, we hypothesized (H1) that the irregularity of PMs and their respective control, and the control tightness will display the n-shape. Furthermore, according to the minimal intervention principle (H2) different PMs should be affected differently. Finally, (H3) we expected stronger dual-tasking effects in the older population, due to limited cognitive resources. We measured the kinematics of forty-one healthy volunteers (23 aged 26 ± 3; 18 aged 59 ± 4) performing 80 s tandem stances in five conditions (single-task and auditory n-back task; n = 1–4), and computed sample entropies on PM time-series and two novel measures of control tightness. In the PM most critical for stability, the control tightness decreased steadily, and in contrast to H3, decreased further for the younger group. Nevertheless, we found n-shapes in most variables with differing magnitudes, supporting H1 and H2. These results suggest that the control tightness might deteriorate steadily with increased cognitive load in critical movements despite the otherwise eminent n-shaped relationship.
Negation of Belief Function Based on the Total Uncertainty Measure
Authors: Xie Kangyang , Xiao Fuyuan
Published: January 2019

The negation of probability provides a new way of looking at information representation. However, the negation of basic probability assignment (BPA) is still an open issue. To address this issue, a novel negation method of basic probability assignment based on total uncertainty measure is proposed in this paper. The uncertainty of non-singleton elements in the power set is taken into account. Compared with the negation method of a probability distribution, the proposed negation method of BPA differs becausethe BPA of a certain element is reassigned to the other elements in the power set where the weight of reassignment is proportional to the cardinality of intersection of the element and each remaining element in the power set. Notably, the proposed negation method of BPA reduces to the negation of probability distribution as BPA reduces to classical probability. Furthermore, it is proved mathematically that our proposed negation method of BPA is indeed based on the maximum uncertainty.
Design of Voltage Mode Electronically Tunable First Order All Pass Filter in ±0.7 V 16 nm CNFET Technology
Authors: Masud Muhammad , A’ain Abu , Khan Iqbal , Husin Nasir
Published: January 2019

A novel voltage mode first order active only tuneable all pass filter (AOTAPF) circuit configuration is presented. The AOTAPF has been designed using ±0.7 V, 16 nm carbon nanotube field effect transistor (CNFET) Technology. The circuit uses CNFET based varactor and unity gain inverting amplifier (UGIA). The presented AOTAPF is realized with three N-type CNFETs and without any external passive components. It is to be noted that the realized circuit uses only two CNFETs between its supply-rails and thus, suitable for low-voltage operation. The electronic tunability is achieved by varying the voltage controlled capacitance of the employed CNFET varactor. By altering the varactor tuning voltage, a wide tunable range of pole frequency between 34.2 GHz to 56.9 GHz is achieved. The proposed circuit does not need any matching constraint and is suitable for multi-GHz frequency applications. The presented AOTAPF performance is substantiated with HSPICE simulation program for 16 nm technology-node, using the well-known Stanford CNFET model. AOTAPF simulation results verify the theory for a wide frequency-range.
Certificate Based Security Mechanisms in Vehicular Ad-Hoc Networks based on IEC 61850 and IEEE WAVE Standards
Authors: Farooq Shaik Mullapathi , Hussain S. M. Suhail , Kiran Siddavaram , Ustun Taha Selim
Published: January 2019

When equipped with an on-board wireless kit, electric vehicles (EVs) can communicate with nearby entities, e.g., road side units (RSUs), via a vehicle ad-hoc network (VANET). More observability enables smart charging algorithms where charging stations (CSs) are allocated to EVs based on their current state of charge, destination, and urgency to charge. IEEE 1609 WAVE standard regulates VANETs, while IEC 61850 is emerging as the smart grid communication standard. In order to integrate these two domains of energy management, past research has focused on harmonizing these two standards for a full smart city solution. However, this solution requires very sensitive data to be transmitted, such as ownership of EV, owners’ personal details, and driving history. Therefore, data security in these networks is of prime concern and needs to be addressed. In this paper, different security mechanisms defined by the IEEE 1609 WAVE standard are applied for both vehicle-to-infrastructure (V2I) and vehicle-to-grid (V2G) communication. The former relates to EV–RSU, while the latter covers EV–CS communication. The implicit and explicit certificate mechanism processes proposed in IEEE 1609 WAVE for authentication are studied in great detail. Furthermore, a performance evaluation for these mechanisms is presented in terms of total time lapse for authentication, considering both the computational time and communication time delays. These results are very important in understanding the extra latency introduced by security mechanisms. Considering that VANETs may be volatile and may disappear as EVs drive away, overall timing performance becomes vital for operation. Reported results show the magnitude of this impact and compare different security mechanisms. These can be utilized to further develop VANET security approaches based on available time and the required security level.
Strength Behaviors of Remolded Hydrate-Bearing Marine Sediments in Different Drilling Depths of the South China Sea
Authors: Li Yanghui , Luo Tingting , Sun Xiang , Liu Weiguo , Li Qingping , Li Yuanping , Song Yongchen
Published: January 2019

The mechanical behaviors of hydrate-bearing marine sediments (HBMS) drilled from the seafloor need to be understood in order to safely exploit natural gas from marine hydrate reservoirs. In this study, hydrates were prepared using ice powder and CH4 gas, and HBMS from the Shenhu area in the South China Sea were remolded using a mixed sample preparation method. A series of triaxial tests were conducted on the remolded HBMS to investigate the effects of soil particle gradation and the existence of hydrate on the mechanical properties of hydrate reservoirs. The results show that the stiffness and failure strength of HBMS decrease along with the decrease of mean particle size and soil aggregate morphology change at different drilling depths, and the reduction of failure strength is more than 20% when the drilling depth drops by 30 m. A better particle gradation of marine sediments may boost the stiffness and failure strength of HBMS. In addition, the existence of hydrate plays an important role in the strength behaviors of HBMS. The reduction of failure strength of HBMS with 30% initial hydrate saturation is more than 35% after complete hydrate dissociation.
Numerical Calculation Method of Model Predictive Control for Integrated Vehicle Thermal Management Based on Underhood Coupling Thermal Transmission
Authors: Lu Pengyu , Gao Qing , Lv Liang , Xue Xiaoye , Wang Yan
Published: January 2019

The nonlinear model predictive control (NMPC) controller is designed for an engine cooling system and aims to control the pump speed and fan speed according to the thermal load, vehicle speed, and ambient temperature in real time with respect to the coolant temperature and comprehensive energy consumption of the system, which serve as the targets. The system control model is connected to the underhood computational fluid dynamics (CFD) model by the coupling thermal transmission equation. For the intricate thermal management process predictive control and system control performance analysis, a coupling multi-thermodynamic system nonlinear model for integrated vehicle thermal management was established. The concept of coupling factor was proposed to provide the boundary conditions considering the thermal transmission interaction of multiple heat exchangers for the radiator module. Using the coupling factor, the thermal flow influence of the structural characteristics in the engine compartment was described with the lumped parameter method, thereby simplifying the space geometric feature numerical calculation. In this way, the coupling between the multiple thermodynamic systems mathematical model and multidimensional nonlinear CFD model was realized, thereby achieving the simulation and analysis of the integrated thermal management multilevel cooperative control process based on the underhood structure design. The research results indicated an excellent capability of the method for integrated control analysis, which contributed to solving the design, analysis, and optimization problems for vehicle thermal management. Compared to the traditional engine cooling mode, the NMPC thermal management scheme clearly behaved the better temperature controlling effects and the lower system energy consumption. The controller could further improve efficiency with reasonable coordination of the convective thermal transfer intensity between the liquid and air sides. In addition, the thermal transfer structures in the engine compartment could also be optimized.
Effects of Fertilization Ratios and Frequencies on the Growth and Nutrient Uptake of Magnolia wufengensis (Magnoliaceae)
Authors: Deng Shixin , Shi Kankan , Ma Jiang , Zhang Lili , Ma Luyi , Jia Zhongkui
Published: January 2019

Through this study, the most suitable fertilization ratio, amount and frequency were determined, providing a scientific reference for further fertilization management for Magnolia wufengensis (Magnoliaceae) seedlings. Fertilization is an important cultivation and management measure to maintain forest seedling health and rapid growth. However, improper fertilization can also have unexpected effects: inhibiting seedling growth, increasing the cost of production and contaminating the environment. Thus, to explore the most suitable fertilization treatment for Magnolia wufengensis growth, one-year-old Magnolia wufengensis seedlings and the orthogonal design method were used in this study. Three different fertilization frequencies were used combined with 9 NPK ratios. The growth index, chlorophyll content, nutrient content in tissues, nutrient transport efficiency, nutrient uptake, and soil properties were analyzed. Fertilization can increase chlorophyll content, promoting the vegetative growth and biomass accumulation of Magnolia wufengensis. Fertilization reduced the proportion of root biomass to whole plant biomass, resulting in an increase in stem biomass with little effect on leaf biomass. Additionally, fertilization also increased the proportion of N in roots, P in stems and K in leaves. Under fertilization, the K transport efficiency was higher than that of N and P. Furthermore, there was a positive correlation between the nutrient use efficiencies of N and K. Overall, the effects of six fertilizer applications were much better than those of four and eight fertilizer applications on the promotion of vegetative growth, biomass and nutrient accumulation, nutrient uptake and transport efficiency. The results showed that six fertilizer applications with an NPK ratio of 3:2:1 as follows: N application at 480 mg/plant, P application at 320 mg/plant, and K application at 160 mg/plant was the most suitable fertilization method for plant growth.
Dry Season Irrigation Promotes Leaf Growth in Eucalyptus urophylla × E. grandis under Fertilization
Authors: Yu Fei , Truong Thuy Van , He Qian , Hua Lei , Su Yan , Li Jiyue
Published: January 2019

Leaves are essential for photosynthesis and gas exchange, and their growth characteristics are the key factors that influence the carbon budget. Eucalyptus is widely afforested in south China due to its fast-growing and high-yield features. Water and fertilizer are the main factors affecting plant growth. Studying the effects of different water and fertilizer treatments on the growth of Eucalyptus leaves under seasonal drought could further elucidate the optimal additions for Eucalyptus productivity. In this study, we investigated the leaf area, length, width, perimeter, and expansion rates of the commercial species E. urophylla × E. grandis under different treatments of dry season irrigation and fertilizer application to elucidate the growth dynamics of the leaves. The results indicated that both dry season irrigation and fertilizer could affect whole leaf expansion. Leaf area was largest when water and fertilizer were added at the same time. In this experiment, we found that fertilization had a significant effect on the leaf shape index of the Eucalyptus leaves. The leaf shape index was larger with the fertilizer treatment, which made the leaves slender. Dry season irrigation shorten the peak period of leaf growth and increase the leaf area. Our results help to further understand the mechanism of Eucalyptus productivity under seasonal drought and provide theoretical support for Eucalyptus production.
Adaptive Downward/Upward Routing Protocol for Mobile-Sensor Networks
Authors: Wang Jinpeng , Chalhoub Gérard , Misson Michel
Published: January 2019

Recently, mobility support has become an important requirement in various Wireless Sensor Networks (WSNs). Low-power and Lossy Networks (LLNs) are a special type of WSNs that tolerate a certain degree of packet loss. However, due to the strict resource constraints in the computation, energy, and memory of LLNs, most routing protocols only support static network topologies. Data collection and data dissemination are two basic traffic modes in LLNs. Unlike data collection, data dissemination is less investigated in LLNs. There are two sorts of data-dissemination methods: point-to-multipoint and point-to-point. In this paper, we focus on the point-to-point method, which requires the source node to build routes to reach the destination node. We propose an adaptive routing protocol that integrates together point-to-point traffic and data-collection traffic, and supports highly mobile scenarios. This protocol quickly reacts to the movement of nodes to make faster decisions for the next-hop selection in data collection and dynamically build routes for point-to-point traffic. Results obtained through simulation show that our work outperforms two generic ad hoc routing protocols AODV and flooding on different performance metrics. Results also show the efficiency of our work in highly mobile scenarios with multiple traffic patterns.
Advances in the Dereplication of Aroma Precursors from Grape Juice by Pretreatment with Lead Acetate and Combined HILIC- and RP-HPLC Methods
Authors: D’Ambrosio Michele
Published: January 2019

Glycosidic aroma precursors (GAPs) contribute to the varietal flavor of wine. Researchers have applied various sample preparation and analytical methods in attempts to achieve their separation and identification. However, mass spectrometric methods still fail to unequivocally define their structures. We have previously reported the separation of GAPs in their natural form and elucidated their structures by nuclear magnetic resonance (NMR) spectroscopy. In this study, we confirm the effectiveness of our established procedure and present methodological improvements. Grape juice was treated with lead (II) acetate and repeatedly chromatographed to give seven pure GAPs. Their chemical structures were characterized by MSn fragmentations and 1D- and 2D-NMR spectra. Ten GAPs were analyzed by both hydrophilic interaction liquid chromatography (HILIC) and reversed phase high performance liquid chromatography (RP-HPLC) to compare the two chromatograms. A selection of known phenols was treated with lead (II) acetate in order to check its binding properties.
Animal Models and Their Contribution to Our Understanding of the Relationship Between Environments, Epigenetic Modifications, and Behavior
Authors: Phillips Natalia Ledo Husby , Roth Tania L.
Published: January 2019

The use of non-human animals in research is a longstanding practice to help us understand and improve human biology and health. Animal models allow researchers, for example, to carefully manipulate environmental factors in order to understand how they contribute to development, behavior, and health. In the field of behavioral epigenetics such approaches have contributed novel findings of how the environment physically interacts with our genes, leading to changes in behavior and health. This review highlights some of this research, focused on prenatal immune challenges, environmental toxicants, diet, and early-life stress. In conjunction, we also discuss why animal models were integral to these discoveries and the translational relevance of these discoveries.
Petrological and Mineralogical Aspects of Epithermal Low-Sulfidation Au- and Porphyry Cu-Style Mineralization, Navilawa Caldera, Fiji
Authors: Forsythe Nathan A. , Spry Paul G. , Thompson Michael L.
Published: January 2019

The Navilawa caldera is the remnant of a shoshonitic volcano on Viti Levu, Fiji, and sits adjacent to the low-sulfidation Tuvatu epithermal Au–Te deposit. The caldera occurs along the Viti Levu lineament, approximately 50 km SW of the Tavua caldera, which hosts the giant low-sulfidation Emperor epithermal Au–Te deposit. Both calderas host alkaline rocks of nearly identical age (~5.4–4.6 Ma) and mineralization that occurred in multiple stages. The gold mineralization in these locations is spatially and genetically related to monzonite intrusions and low-grade porphyry Cu-style mineralization. Potassic, propylitic, phyllic, and argillic alteration extends from the Tuvatu Au–Te deposit towards the central, northern, and eastern parts of the Navilawa caldera where it is spatially associated with low-grade porphyry Cu–Au mineralization at the Kingston prospect and various epithermal Au–(Te) vein systems, including the Banana Creek and Tuvatu North prospects. Chalcopyrite, and minor bornite, occurs in quartz–calcite–(adularia) veins in the Kingston deposit associated with weak propylitic and phyllic alteration, whereas NE-trending epithermal gold veins at the Banana Creek and Tuvatu North prospects are associated with weak potassic alteration that is overprinted by propylitic and phyllic alteration. Gold is accompanied by chalcopyrite, galena, and sphalerite in quartz–pyrite veins that also have a Ag–As–Hg–Te signature. The temperature range for phyllosilicates in the phyllic alteration (chlorite ± smectite ± corrensite ± illite) is in good agreement with temperatures recorded from previous fluid inclusion studies of quartz at the Banana Creek Au prospect (~260 °C) and the nearby Tuvatu Au–Te deposit (205 to 382 °C). Sulfur isotope compositions of pyrite (−6.2 to +0.4‰) from the Banana Creek prospect indicate a likely magmatic source of sulfur. Oxidation of the ore fluids or a direct addition of volatiles to the hydrothermal fluids may account for the lighter isotopic values. The similarities of the igneous rock types and compositions, transition from porphyry- to epithermal-style mineralization, alteration assemblages, paragenetic relationships, and stable isotope data suggest a common origin for the porphyry- and epithermal-style mineralization within the Navilawa and between the Navilawa and Tavua calderas.
Sex-Specific Lifestyle and Biomedical Risk Factors for Chronic Disease among Early-Middle, Middle and Older Aged Australian Adults
Authors: Dash Sarah R. , Hoare Erin , Varsamis Pia , Jennings Garry L. R. , Kingwell Bronwyn A.
Published: January 2019

Evidence suggests age and sex differences in risk factors for chronic disease. This study examined lifestyle and biomedical risk factors among men (m) and women (w) in early-middle (25–51 years), middle (52–64) and older (65+) adulthood. Cross-sectional data from the 2011–2012 Australian Health Survey (n = 3024) were analysed. Self-reported dietary, activity, sleep behaviours and collected biomedical data were analysed. Early-middle adults failed to meet fruit, vegetable (95.3%) and sugar-sweetened beverage (SSB, 34.9%) recommendations. Older adults had higher prevalence of overweight/obesity (70%), high blood pressure (38.0%) and fewer met physical activity guidelines (36.3%). Prior to older adulthood, more men consumed SSBs (early-middle m 45.6%, w 24.4%; middle m 26.0%, w 19.3%), and fewer met sedentary behaviour recommendations (early-middle m 43.2%, w 62.1%; middle m 46.4%, w 63.9%). Differences in overweight/obese women in early-middle (44.8%) to middle adulthood (64.7%) were significant. Biomedical risk was greatest in middle age; abnormal cholesterol/lipids increased specifically for women (total cholesterol early-middle 24.9% middle 56.4%; abnormal LDL-cholesterol early-middle 23.1% middle 53.9%). Adherence to lifestyle guidelines was low; particularly among men. While men exhibited greater clinical risk overall, this significantly increased among women in middle-adulthood. Public health strategies to improve lifestyle, monitor and intervene among middle-aged women are warranted.
Nutritional Status of Elderly Patients after Coronary Artery Bypass Surgery
Authors: Ścisło Lucyna , Bizoń Aleksandra , Walewska Elżbieta , Staszkiewicz Magdalena , Pach Radosław , Szczepanik Antoni
Published: January 2019

Surgical trauma can result in immobilization of biological material, degradation of muscle proteins, synthesis of acute-phase proteins in the liver, occurrence of catabolism phase and anabolism simultaneously, and as a consequence weight loss and nutritional deficiencies. The aim of this study was to assess the nutritional status of patients with ischemic heart disease subjected to coronary artery bypass surgery and physical activity and postoperative complications. The analysis among 96 men included total number of lymphocytes (TNL), body mass index (BMI), case history of a patient and results of laboratory tests. The activities of daily living (ADL) and the mini nutritional assessment (MNA) questionnaires were used. According to TNL, before the procedure malnutrition occurred in 46% of patients. BMI revealed overweight in 62.5% and obesity in 26.0%. After the surgery, no changes were observed. According to MNA, 59% of patients before the surgery were at risk of malnutrition. After the operation, the number of people at risk of malnutrition increased by 50% (p < 0.0001). The correlation was noted between BMI and patients’ efficiency in the fifth day after the surgery (p = 0.0031). Complications after the surgery occurred in 35.4% of patients. After the surgery, the risk of malnutrition increased, decreased activity and complications occurred more frequently in people with underweight, obesity, and overweight than in people with normal BMI.
Health Emergency Disaster Risk Management of Public Transport Systems: A Population-Based Study after the 2017 Subway Fire in Hong Kong, China
Authors: Chan Emily Ying Yang , Huang Zhe , Hung Kevin Kei Ching , Chan Gloria Kwong Wai , Lam Holly Ching Yu , Lo Eugene Siu Kai , Yeung May Pui Shan
Published: January 2019

Background: Literature on health emergency disaster risk management (Health-EDRM) for urban public transport safety is limited. This study explored: (i) the confidence in public transport safety, (ii) the relationship between socio-demographic characteristics and risk perception of transport safety and (iii) the association between previous first-aid training and response knowledge. Method: This is a population-based cross-sectional telephone survey conducted in March 2017, one month after a major subway incident in Hong Kong. Respondents were randomly selected with the Random Digit Dialing method among Cantonese-speaking population ≥15 years. Sociodemographic information, type of transport used and the corresponding worries, response knowledge and previous first-aid training experience (as a proxy for individual skills in Health-EDRM training proxy) were collected. Results: Among the 1000 respondents, 87% used public transport daily. The self-reported confidence in subway safety was 85.6% even after a subway fire accident. Female, those with lower income and people unmarried were more likely to express worry about transport safety. About 46.1–63.2% respondents had the correct fire related health response knowledge. Previous first-aid training (32%) was found to be associated with fire response knowledge in a mixed pattern. Conclusions: Despite inadequacy in fire response knowledge, previous first-aid training appeared to be a beneficial factor for emergency response knowledge. Emergency responses education should be provided to the public to reduce health losses during emergencies.
Trust in the Work Environment and Cardiovascular Disease Risk: Findings from the Gallup-Sharecare Well-Being Index
Authors: Alterman Toni , Tsai Rebecca , Ju Jun , Kelly Kevin M.
Published: January 2019

This study examined associations between trust, an important aspect of workplace social capital, with seven cardiovascular disease (CVD) risk factors (American Heart Association Life’s Simple 7 (LS7)): smoking, obesity, low physical activity, poor diet, diabetes, high cholesterol, and high blood pressure. Data are from the U.S. Gallup-Sharecare Well-Being Index (2010–2012), a nationally representative telephone survey of U.S. workers (n = 412,884). The independent variable was the response to a work environment (WE) question as to whether their supervisor always creates an open and trusting environment. Regression models were adjusted for demographic characteristics with each of the LS7 CVD risk factors as dependent variables. Twenty-one percent of workers reported that their supervisor did not create an open and trusting environment. Trust was associated with increased adjusted odds of having many of the LS7 CVD risk factors. Among those workers whose supervisor created a mistrustful environment, the odds ratios were greatest (>20%) for having four or more of the LS7 CVD risk factors.
Barriers to the Prevention and Control of Hepatitis B and Hepatitis C in the Community of Southwestern China: A Qualitative Research
Authors: Li Tingting , Su Shu , Zhao Yong , Deng Runze , Fan Mingyue , Wang Ruoxi , Sharma Manoj , Zeng Huan
Published: January 2019

Objective viral hepatitis is a big challenge in China. However, few studies have focused on mapping the difficulties from a broader view. This study aimed to identify the barriers to the prevention and control of hepatitis B and hepatitis C in communities from the perspectives of hepatitis patients, residents, and healthcare providers. A total of 26 participants were recruited through purposive sampling. Data were collected by in-depth face-to-face interviews from September 2015 to May 2016 in two communities from Chongqing and Chengdu, China. A thematic framework was applied to analyze the qualitative data from the interviews. The critical factors of barriers to hepatitis prevention and control in the districts included poor cognition of residents regarding hepatitis B and hepatitis C, severe stigma in society, inadequate health education, and the provision of unsatisfactory medical services. Strengthening health education and improving services for treating patients with hepatitis are suggested to make further progress. A substantial gap remains between the need and currently available services for hepatitis patients and residents. Delivering quality prevention and control health services, improving health education, and reducing stigma in society are recommended to improve the prevention and control program for hepatitis B and C in communities.
Effect of a Multidimensional Physical Activity Intervention on Body Mass Index, Skinfolds and Fitness in South African Children: Results from a Cluster-Randomised Controlled Trial
Authors: Müller Ivan , Schindler Christian , Adams Larissa , Endes Katharina , Gall Stefanie , Gerber Markus , Htun Nan S. N. , Nqweniso Siphesihle , Joubert Nandi , Probst-Hensch Nicole , du Randt Rosa , Seelig Harald , Smith Danielle , Steinmann Peter , Utzinger Jürg , Yap Peiling , Walter Cheryl , Pühse Uwe
Published: January 2019

Obesity-related conditions impose a considerable and growing burden on low- and middle-income countries, including South Africa. We aimed to assess the effect of twice a 10-week multidimensional, school-based physical activity intervention on children’s health in Port Elizabeth, South Africa. A cluster-randomised controlled trial was implemented from February 2015 to May 2016 in grade 4 classes in eight disadvantaged primary schools. Interventions consisted of physical education lessons, moving-to-music classes, in-class activity breaks and school infrastructure enhancement to promote physical activity. Primary outcomes included cardiorespiratory fitness, body mass index (BMI) and skinfold thickness. Explanatory variables were socioeconomic status, self-reported physical activity, stunting, anaemia and parasite infections. Complete data were available from 746 children. A significantly lower increase in the mean BMI Z-score (estimate of difference in mean change: −0.17; 95% confidence interval (CI): −0.24 to −0.09; p < 0.001) and reduced increase in the mean skinfold thickness (difference in mean change: −1.06; 95% CI: −1.83 to −0.29; p = 0.007) was observed in intervention schools. No significant group difference occurred in the mean change of cardiorespiratory fitness (p > 0.05). These findings show that a multidimensional, school-based physical activity intervention can reduce the increase in specific cardiovascular risk factors. However, a longer and more intensive intervention might be necessary to improve cardiorespiratory fitness.
Long-Term Effects of Psychological Symptoms after Occupational Injury on Return to Work: A 6-Year Follow-Up
Authors: Chu Po-Ching , Chin Wei-Shan , Guo Yue Leon , Shiao Judith Shu-Chu
Published: January 2019

Psychological factors may compromise return to work among workers with occupational injuries, and little is known about the long-term consequences of psychological symptoms relating to return to work. The study examined the impact of psychological symptoms on return to work as well as exploring factors associated with return to work among injured workers. A total of 572 workers who experienced occupational injuries were recruited in this prospective cohort study. Surveys of the psychological symptoms using the 5-item Brief Symptom Rating Scale (BSRS-5) were conducted at 3 and 12 months after the injury. All of the workers were invited to join the study at year 6 after the injury. Sociodemographic factors, psychological symptoms, injury severity, and return-to-work status were collected. Approximately 10% of injured workers could not return to work even 6 years after the injury. Severe psychological symptoms within 1 year after the injury presented a significant risk factor for not returning to work 6 years after the injury (adjusted OR = 0.7, 95% CI: 0.5–0.8). Furthermore, age, education level, length of hospitalization, and injury-induced changes in appearance had significant independent influence on return to work as well. These findings highlight the importance of the effects of mental health within 1 year post injury on return to work, and support the concept of early screening, detection, and intervention in at-risk occupational injured workers with severe psychological symptoms.
Dissipation Dynamics and Residue of Four Herbicides in Paddy Fields Using HPLC-MS/MS and GC-MS
Authors: Yu Qian , Zhang Ping , He Yuhan , Xu Zhifeng , He Xiulong , Hu Yuan , Zhang Hongjun , He Lin
Published: January 2019

The dissipation dynamics and residue of pyrazosulfuron-ethyl, bensulfuron-methyl, acetochlor, and butachlor in paddy fields at Good Agricultural Practices (GAP) condition were carefully investigated in this study. The four herbicides’ residues were determined based on a quick, easy, cheap, rugged, safe (QuEChERS) method coupled with HPLC-MS/MS and GC-MS. The limit of detection (LOD) for pyrazosulfuron-ethyl, bensulfuron-methyl, acetochlor, and butachlor in all matrices ranged from 0.04–1.0 ng. The limit of quantification (LOQ) of the four herbicides ranged from 0.01–0.1 mg/kg. Moreover, the average recoveries of the four herbicides ranged from 78.9–108% with relative standard deviations (RSDs) less than 15% at three different fortified levels for different matrices. The dissipation results indicated that the average half-lives (t1/2) of the four herbicides in soil were in the range of 3.5–17.8 days, and more than 95% of the four herbicides dissipated within 5 days in water. Furthermore, the final residues of the four herbicides were all below the LOQ at harvest time. Such results highlight the dissipation dynamics and residue of the four herbicides in a rice cropping system and contribute to risk assessment as well as scientific guidance on the proper and safe application of herbicides in paddy fields.
Heart Rate Variability and Performance of Commercial Airline Pilots during Flight Simulations
Authors: Cao Xiaodong , MacNaughton Piers , Cadet Leslie R. , Cedeno-Laurent Jose Guillermo , Flanigan Skye , Vallarino Jose , Donnelly-McLay Deborah , Christiani David C. , Spengler John D. , Allen Joseph G.
Published: January 2019

Pilots undergo a variety of stressors that may affect their performance during all phases of flight. Heart rate variability (HRV) has been considered as a reliable indicator of the parasympathetic and sympathetic activities of human autonomic nervous system, which can be used to characterize the sympathetic stress response of pilots during flight. In this study, thirty active commercial airline pilots were recruited to fly three flight segments in a Federal Aviation Administration (FAA)-certified A320 flight simulator with each segment at a different carbon dioxide (CO2) concentration on the flight deck. The pilots performed a series of maneuvers of varying difficulty, and their performance was evaluated by FAA designated pilot examiners. The HRV metrics (SDNN, RMSSD and LF/HF ratio) of each pilot both before and during flight simulations were measured with a Movisens EcgMove3 sensor. The average SDNN, RMSSD and LF/HF ratio of the pilots during flight simulations were 34.1 ± 12.7 ms, 23.8 ± 10.2 ms and 5.7 ± 2.8 respectively. Decreased HRV was associated with aging, obesity and performing difficult maneuvers. Both CO2 exposure and HRV had an independent effect on the pilot performance, while their interaction was not significant. The generalized additive mixed effect model results showed that a pilot performed better on a maneuver when his stress response was lower, as indicated by higher SDNN and RMSSD and lower LF/HF ratio. An interquartile range (IQR) increase in SDNN (21.97 ms) and RMSSD (16.00 ms) and an IQR decrease in LF/HF ratio (4.69) was associated with an increase in the odds of passing a maneuver by 37%, 22% and 20%, respectively.
The Association between Social Support and Incident Dementia: A 10-Year Follow-Up Study in Japan
Authors: Murata Chiyoe , Saito Tami , Saito Masashige , Kondo Katsunori
Published: January 2019

Social support is important for the health of elderly populations. However, its longitudinal effect on incident dementia is unclear. We used the Aichi Gerontological Evaluation Study (AGES) project data to investigate the longitudinal effect of social support on dementia onset. Functionally independent older people at baseline (n = 14,088) in 10 municipalities were followed from 2003 to 2013 using National Long-term Care Insurance System data. Social support was assessed by the following support sources: co-residing family, family or relatives living apart, and friends or neighbors. Cumulative incidence of dementia was 14.6% and 18.7% for men and women, respectively. Cox proportional hazard models were employed by gender to investigate the association between social support and dementia onset adjusting for age, health status, health behaviors, subjective cognitive complaints, depression, and other socioeconomic factors. Gender differences were observed in the association between social support and incident dementia. Support from co-residing family members was protective among men, whereas among women, no effect of social support on dementia was observed. Among other social factors, community engagement was protective for women, while for men, being married was associated with lower incidence of dementia. The association between social support and dementia seems to differ by gender. When we design programs to promote social interactions among the elderly, we need to take into account such gender differences.
Social Media Big Data Mining and Spatio-Temporal Analysis on Public Emotions for Disaster Mitigation
Authors: Yang Tengfei , Xie Jibo , Li Guoqing , Mou Naixia , Li Zhenyu , Tian Chuanzhao , Zhao Jing
Published: January 2019

Social media contains a lot of geographic information and has been one of the more important data sources for hazard mitigation. Compared with the traditional means of disaster-related geographic information collection methods, social media has the characteristics of real-time information provision and low cost. Due to the development of big data mining technologies, it is now easier to extract useful disaster-related geographic information from social media big data. Additionally, many researchers have used related technology to study social media for disaster mitigation. However, few researchers have considered the extraction of public emotions (especially fine-grained emotions) as an attribute of disaster-related geographic information to aid in disaster mitigation. Combined with the powerful spatio-temporal analysis capabilities of geographical information systems (GISs), the public emotional information contained in social media could help us to understand disasters in more detail than can be obtained from traditional methods. However, the social media data is quite complex and fragmented, both in terms of format and semantics, especially for Chinese social media. Therefore, a more efficient algorithm is needed. In this paper, we consider the earthquake that happened in Ya’an, China in 2013 as a case study and introduce the deep learning method to extract fine-grained public emotional information from Chinese social media big data to assist in disaster analysis. By combining this with other geographic information data (such population density distribution data, POI (point of interest) data, etc.), we can further assist in the assessment of affected populations, explore emotional movement law, and optimize disaster mitigation strategies.
De Novo Assembly and Discovery of Genes That Involved in Drought Tolerance in the Common Vetch
Authors: Zhu Yongqun , Liu Qiuxu , Xu Wenzhi , Zhang Jianhua , Wang Xie , Nie Gang , Yao Li , Wang Hong , Lin Chaowen
Published: January 2019

The common vetch (Vicia sativa) is often used as feed for livestock because of its high nutritional value. However, drought stress reduces forage production through plant damage. Here, we studied the transcriptional profiles of common vetch exposed to drought in order to understand the molecular mechanisms of drought tolerance in this species. The genome of the common vetch has not been sequenced, therefore we used Illumina sequencing to generate de novo transcriptomes. Nearly 500 million clean reads were used to generate 174,636 transcripts, including 122,299 unigenes. In addition, 5313 transcription factors were identified and these transcription factors were classified into 79 different gene families. We also identified 11,181 SSR loci from di- to hexa-nucleotides whose repeat number was greater than five. On the basis of differentially expressed genes, Gene Ontology analysis identified many drought-relevant categories, including “oxidation-reduction process”, “lipid metabolic process” and “oxidoreductase activity”. In addition to these, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis identified pathways, such as “Plant hormone signal transduction”, “Glycolysis/Gluconeogenesis” and “Phenylpropanoid biosynthesis”, as differentially expressed in the plants exposed to drought. The expression results in this study will be useful for further extending our knowledge on the drought tolerance of common vetch.
A Computational Method to Propose Mutations in Enzymes Based on Structural Signature Variation (SSV)
Authors: Mariano Diego César Batista , Santos Lucianna Helene , Machado Karina dos Santos , Werhli Adriano Velasque , de Lima Leonardo Henrique França , de Melo-Minardi Raquel Cardoso
Published: January 2019

With the use of genetic engineering, modified and sometimes more efficient enzymes can be created for different purposes, including industrial applications. However, building modified enzymes depends on several in vitro experiments, which may result in the process being expensive and time-consuming. Therefore, computational approaches could reduce costs and accelerate the discovery of new technological products. In this study, we present a method, called structural signature variation (SSV), to propose mutations for improving enzymes’ activity. SSV uses the structural signature variation between target enzymes and template enzymes (obtained from the literature) to determine if randomly suggested mutations may provide some benefit for an enzyme, such as improvement of catalytic activity, half-life, and thermostability, or resistance to inhibition. To evaluate SSV, we carried out a case study that suggested mutations in β-glucosidases: Essential enzymes used in biofuel production that suffer inhibition by their product. We collected 27 mutations described in the literature, and manually classified them as beneficial or not. SSV was able to classify the mutations with values of 0.89 and 0.92 for precision and specificity, respectively. Then, we used SSV to propose mutations for Bgl1B, a low-performance β-glucosidase. We detected 15 mutations that could be beneficial. Three of these mutations (H228C, H228T, and H228V) have been related in the literature to the mechanism of glucose tolerance and stimulation in GH1 β-glucosidase. Hence, SSV was capable of detecting promising mutations, already validated by in vitro experiments, that improved the inhibition resistance of a β-glucosidase and, consequently, its catalytic activity. SSV might be useful for the engineering of enzymes used in biofuel production or other industrial applications.
The Immune Escape Mechanisms of Mycobacterium Tuberculosis
Authors: Zhai Weijie , Wu Fengjuan , Zhang Yiyuan , Fu Yurong , Liu Zhijun
Published: January 2019

Epidemiological data from the Center of Disease Control (CDC) and the World Health Organization (WHO) statistics in 2017 show that 10.0 million people around the world became sick with tuberculosis. Mycobacterium tuberculosis (MTB) is an intracellular parasite that mainly attacks macrophages and inhibits their apoptosis. It can become a long-term infection in humans, causing a series of pathological changes and clinical manifestations. In this review, we summarize innate immunity including the inhibition of antioxidants, the maturation and acidification of phagolysosomes and especially the apoptosis and autophagy of macrophages. Besides, we also elaborate on the adaptive immune response and the formation of granulomas. A thorough understanding of these escape mechanisms is of major importance for the prevention, diagnosis and treatment of tuberculosis.
The Effect of Dexamethasone, Adrenergic and Cholinergic Receptor Agonists on Phospholipid Metabolism in Human Osteoarthritic Synoviocytes
Authors: Sluzalska Katarzyna D. , Liebisch Gerhard , Ishaque Bernd , Schmitz Gerd , Rickert Markus , Steinmeyer Juergen
Published: January 2019

Phospholipids (PLs) possess the unique ability to contribute to synovial joint lubrication. The aim of our study was to determine for the first time the effect of dexamethasone and some adrenergic and cholinergic agonists on the biosynthesis and release of PLs from human fibroblast-like synoviocytes (FLS). Osteoarthritic human knee FLS were treated with dexamethasone, terbutaline, epinephrine, carbachol, and pilocarpine, or the glucocorticoid receptor antagonist RU 486. Simultaneously PL biosynthesis was determined through the incorporation of stable isotope-labeled precursors into PLs. Radioactive isotope-labeled precursors were used to radiolabel PLs for the subsequent quantification of their release into nutrient media. Lipids were extracted and quantified using electrospray ionization tandem mass spectrometry or liquid scintillation counting. Dexamethasone significantly decreased the biosynthesis of phosphatidylcholine, phosphatidylethanolamine (PE), PE-based plasmalogen, and sphingomyelin. The addition of RU 486 abolished these effects. A release of PLs from FLS into nutrient media was not recognized by any of the tested agents. None of the adrenergic or cholinergic receptor agonists modulated the PL biosynthesis. We demonstrate for the first time an inhibitory effect of dexamethasone on the PL biosynthesis of FLS from human knees. Moreover, our study indicates that the PL metabolism of synovial joints and lungs are differently regulated.
Mechanisms of Communication in the Mammalian Circadian Timing System
Authors: Astiz Mariana , Heyde Isabel , Oster Henrik
Published: January 2019

24-h rhythms in physiology and behaviour are organized by a body-wide network of endogenous circadian clocks. In mammals, a central pacemaker in the hypothalamic suprachiasmatic nucleus (SCN) integrates external light information to adapt cellular clocks in all tissues and organs to the external light-dark cycle. Together, central and peripheral clocks co-regulate physiological rhythms and functions. In this review, we outline the current knowledge about the routes of communication between the environment, the main pacemakers and the downstream clocks in the body, focusing on what we currently know and what we still need to understand about the communication mechanisms by which centrally and peripherally controlled timing signals coordinate physiological functions and behaviour. We highlight recent findings that shed new light on the internal organization and function of the SCN and neuroendocrine mechanisms mediating clock-to-clock coupling. These findings have implications for our understanding of circadian network entrainment and for potential manipulations of the circadian clock system in therapeutic settings.