bluuebunny/crossref_metadata_2025 huggingface dataset:
Relationship of Common Variants in Krüppel-like Factor 7 Gene With Susceptibility and Prognosis of Oral Squamous Cell Carcinoma
Authors: Wang Lili , Song Hongguang , Yang Shiming
Published: July 2020

Background: The aim of this study was to assess the prognostic value of Krüppel-like factor 7 (KLF7) for patients with oral squamous cell carcinoma(OSCC).Methods: The expression of KLF7 was detected by quantitative real-time polymerase chain reaction (qRT-PCR) in pairs of tumor tissues and adjacent non-tumor tissues of OSCC. Chi-square (χ2) test was applied to evaluate the association of KLF7 expression with clinicopathological characteristics of OSCC patients. Overall survival was estimated using the Kaplan-Meier method with log rank test. The cox proportional hazards model was used for univariate and multivariate analyses.Results: The expression of KLF7 was remarkably increased in OSCC tissues compared with adjacent non-tumor tissues (P<0.001). KLF7 expression was related to TNM stage (P=0.006), tumor size (P=0.010), smoking (P=0.006) and drinking (P=0.000). Kaplan-Meier analysis showed that OSCC patients with high KLF7 expression had a poorer overall survival than those with low expression (log rank test, P=0.018). Moreover, multivariate analyses showed that KLF7 was an independent prognostic factor for OSCC (P=0.002 HR=2.645 95%CI: 1.426-4.906).Conclusion: Decreased expression of KLF7 may be a potential unfavorable prognostic factor for patients with OSCC.
Relationship of Common Variants in PRL-3 Gene With Susceptibility and Prognosis of Prostate Cancer
Authors: Cao Shuangqing , Zheng Lei
Published: July 2020

Background: Phosphatase of regenerating liver-3 (PRL-3) was involved in a variety of malignancies. In this study, we investigated the expression pattern of PRL-3 and its prognostic significance in prostate cancer (PCa).Methods: The expression profiles of PRL-3 in 126 pairs PCa tissues and adjacent normal specimens were analyzed by quantitative rreal-time polymerase chain reaction (qRT-PCR). Chi-square test was used to estimate the association of PRL-3 level with clinicopathological factors. Survival analysis was performed by Kaplan-Meier method with log rank test. Prognosis analysis was carried out using Cox proportional hazard models.Results: PRL-3 expression was significantly up-regulated in PCa tissues compared to that in normal controls (P<0.001). Moreover, the expression of PRL-3 was positively associated with lymph node metastasis (P=0.038), Gleason score (P=0.003) and lymphovascular invasion (P=0.013). High PRL-3 expression predicted poor overall survival (OS) (log rank test, P=0.019) and dismal BCR-free survival (log rank test, P=0.021) for PCa patients. PRL-3 was an independent prognostic factor for OS (HR=2.619, 95%CI=1.129-6.076, P=0.025) and BCR-free survival (HR=2.120, 95%CI=1.095-4.105, P=0.026) in PCa.Conclusions: PRL-3 expression is elevated in PCa, and exhibits positive association with malignant tumor progression. PRL-3 may serve as a prognostic biomarker for patients with PCa.
Accelerated repurposing and drug development of pulmonary hypertension therapies for COVID-19 treatment using an AI-integrated biosimulation platform
Authors: Chakravarty Kaushik , Antontsev Victor , Jagarapu Aditya , Bundey Yogesh , Hou Hypatia , Maharao Neha , Varshney Jyotika
Published: July 2020

A World Health Organization-declared pandemic, COVID-19, has affected more than 4 million people worldwide with over 100,000 deaths and growing in the United States. Due to the fast-spreading and multi-targeted nature of the virus, it is clear that drugs and/or vaccines need to be developed at an accelerated rate, and a combinatorial approach may stand to be more successful than a single drug therapy. Among several targets and pathways that are under investigation, the renin-angiotensin system (RAS) and specifically Angiotensin converting enzyme (ACE), and Ca2+ -mediated SARS-CoV-2 cellular entry and replication are noteworthy. A combination of ACE inhibitors (e.g. benazepril) and calcium channel blockers (CCB, e.g. amlodipine), a critical line of therapy for pulmonary hypertension, has shown therapeutic relevance in COVID-19 when investigated independently. To that end, we conducted in silico modeling using BIOiSIM, an AI-integrated mechanistic modeling platform by utilizing known preclinical in vitro and in vivo datasets to accurately simulate systemic therapy disposition and site-of-action penetration of the CCB and ACEI compounds to tissues implicated in COVID-19 pathogenesis.
Bioinformatic analysis of the inner heterogeneity within MYCN non-amplified pediatric neuroblastoma sub-group
Authors: Wang Haiwei , Wang Xinrui , Xu Liangpu , Zhang Ji , Cao Hua
Published: July 2020

Background: Pediatric neuroblastoma is divided into MYCN amplified and MYCN non-amplified sub-groups. However, the extent of heterogeneity within MYCN amplified or non-amplified pediatric neuroblastoma is unclear.Methods: The prognostic significance of age and MYCN amplification was determined through multivariate cox regression and Kaplan-Meier survival analysis. MYCN non-amplified pediatric neuroblastoma patients were divided into different sub-consensuses using non-negative matrix factorization (NMF) based on the gene expression profiling. Genes particularly expressed in MYCN non-amplified young neuroblastoma patients were identified using Therapeutically Applicable Research to Generate Effective Treatments (TARGET) and Gene Expression Omnibus (GEO) datasets. The prognostic effects of ALCAM, CACNA2D3, DST, EPB41L4A and KIFIB in MYCN non-amplified pediatric neuroblastoma patients were determined by Kaplan-Meier survival.Results: Age and MYCN amplification were independent prognostic factors in pediatric neuroblastoma. MYCN non-amplified pediatric neuroblastoma comprised young and old two distinct sub-groups. Compared with MYCN non-amplified old neuroblastoma patients, MYCN non-amplified young neuroblastoma patients had better clinical outcomes. MYCN non-amplified pediatric neuroblastoma was divided into three sub-consensuses through NMF assay and each sub-consensus was with significantly different clinical outcomes. However, MYCN amplified pediatric neuroblastoma was relatively homogeneous, and could not divide into sub-groups with different clinical outcomes by age or by NMF assay. ALCAM, CACNA2D3, DST, EPB41L4A and KIFIB were highly expressed in MYCN non-amplified young neuroblastoma patients. Moreover, the high expression levels of ALCAM, CACNA2D3, DST, EPB41L4A or KIFIB were associated with the favorable prognosis of MYCN non-amplified neuroblastoma patients. We also found that DST was an independent prognostic factor in MYCN non-amplified neuroblastoma patients and MYCN non-amplified neuroblastoma young patients with high DST expression levels had the best clinical overall survival.Conclusions: MYCN non-amplified neuroblastoma was a heterogeneous disease and could be divided into sub-groups based on age or the expression levels of ALCAM, CACNA2D3, DST, EPB41L4A or KIFIB. MYCN non-amplified neuroblastoma young patients with high DST expression levels had the best clinical overall survival.
Immune tolerance to asymptomatic submicroscopic Plasmodium falciparum infections in adults living in malaria endemic areas
Authors: Diouf Babacar BD , Diop Fode , Dieye Yakhya , Mbodji Adja Fatou , Talla Cheikh , Thiam Alassane , Dia Ibrahima , Faye Joseph , Sembène Mbacké , Vigan-Womas Inès , Sarr Fatoumata Diène , Perraut Ronald , Toure-Balde Aïssatou , Niang Makhtar
Published: July 2020

Background Combined malaria control interventions have reduced mortality rate, number of clinical cases and parasite prevalence across Africa between 2000 and 2015. As a consequence, Plasmodium infections have become mostly asymptomatic and often sub-microscopic in many endemic areas. The present study aims to evaluate the contribution of asymptomatic sub-microscopic P. falciparum carriage on antibody responses against malaria antigens. Methods A total of 353 samples from a cross-sectional sampling conducted in Ndiop (Senegal) in 2016 were tested by qPCR and microscopy to determine parasite prevalence. Plasmodium falciparum positive samples were genotyped using msp-2 marker. The IgG seroprevalence against crude schizont antigen of a local P. falciparum strain, tested by ELISA, was compared to parasite prevalence. An age-matched, under 10 years, 10-15 and over 15 years cohort of 110 positive and negative qPCR samples were used to determine the impact of sub-microscopic carriage on IgG and IgM antibody responses against schizont extract and MSP3 recombinant antigen. Results The microscopic diagnosis was negative for all thick smears defining a study cohort of submicroscopic asymptomatic individuals with an overall parasite prevalence of 22.37% (79/353) by qPCR. Submicroscopic infections were associated with significant lower IgG responses in qPCR positive samples for individuals over 15 years of age, for both crude schizont (p=0.021) and MSP3 recombinant antigen (p=0.035). IgM responses were significantly higher (p=0.034) in children under 10 years, showing their susceptibility to primary infection. Above 15 years of age, a significant difference was found between parasite prevalence of 9.3% (33/353) and IgG seroprevalence of 23.8% (84/353) (p=0.01). The overall genetic diversity detected is characterized by a complexity of infection (COI) and a number of genotypes of 2.4 and 17, respectively.Conclusion Asymptomatic submicroscopic P. falciparum carriage is prevalent in the study area and is associated with immune tolerance to parasites in adults. The difference between parasite prevalence and IgG seroprevalence results from long-lived IgG in adults point out attention for elders in endemic areas as a stable parasite reservoir. In this context, mass molecular detection followed by treatment could be a valuable method for achieving elimination.
Phenological study of sugar apple (Annona squamosa L.) in dystrophic yellow latosol under the savanna conditions of Roraima
Authors: Moura Elias Ariel de , Chagas Pollyana Cardoso , Chagas Edvan Alves , Oliveira Railin Rodrigues de , Araújo Wellington Farias , Sobral Sara Thiele Moreira , Taveira Daniel Lucas Lima
Published: July 2020

Sugar apple (Annona squamosa L.) is a commercially significant fruit species due to its nutritional qualities. The state of Roraima has excellent soil and climatic conditions for the cultivation of the species. However, no studies on the phenological behavior of this plant have been reported in the literature. In this context, the objective of this work was to investigate the vegetative and reproductive phenological behavior of sugar apple under the savanna conditions of the state of Roraima. The experiment was carried out in four seasons of the year (2014/2014 and 2015/2015 rainy season and 2014/2015 and 2015/2016 Summer). Production pruning was carried out in February 2014 (2014.1 cycle), September 2014 (2014.2 cycle), February 2015 (2015.1 cycle) and September 2015 (2015.2 cycle). Forty plants were monitored during the experiment and evaluated every three days for the following variables: beginning date of bud swelling; duration of flowering; and fruit harvest time. From the observed data, the periods (days) between each phenological stage were calculated: pruning/bud swelling; pruning/beginning of flowering; bud swelling/anthesis; pruning/anthesis; anthesis/beginning of fruit harvest; duration of fruit harvest, and crop cycle (production pruning/harvest). The duration of the cycle, from the production pruning to the harvest varied according to the productive period, recording 146 days for the 2014.1 cycle and 127 days for the 2014.2 cycle, which proves that the phenological behavior of the species is influenced by climatic conditions.
Application of risk solver platform to improve soybean crushing profitability
Authors: Ceratti Geovano , Costa Jéfferson de Oliveira , Harris Keith
Published: July 2020

The growing number of participants in the grain market shows just how globalized this sector is in Brazil nowadays. It is difficult to note how mergers and acquisitions between local companies as major tradings and funds have been acquiring part or even the totality of Brazilian companies, like the soybean crushing company “XYZ” that acquired some assets such as crushing plants in the state of Mato Grosso, located on the center-west region of Brazil and access to 2 port terminals to export the byproducts. This work contains data from January of 2014 to September of 2017 including prices of soybean and by products, freight rates, basis at the ports and operational costs. This information comes from different sources including government and private agencies and Thomson Reuters Eikon software. This information was used to build a model in Microsoft Excel and by using the Risk Solver Platform, a powerful statistic calculator tool, to find a solution to improve “XYZ” profitability. The results of the model suggest changes in the origin of grains, reducing the volume in some locations and increasing the volume originated in other locations. After running 2 different scenarios, “XYZ” profits was increased by 1.24 million of US dollars.
FOME, POBREZA E O PROGRAMA BOLSA FAMÍLIA NO NORTE PIONEIRO DO ESTADO DO PARANÁ
Authors: Carnevalli Fernandes Pedro Henrique , Ludka Vanessa Maria
Published: July 2020

A discussão sobre a fome e a pobreza na Geografia brasileira não é recente. Apesar disso, ainda é possível constatar a presença delas em todas as regiões do território brasileiro. Por isso, as políticas públicas de transferência de renda precisam se manter – e até serem ampliadas em algumas localidades – de modo a incluir e dar uma condição digna aos necessitados. Uma dessas políticas é o Programa Bolsa Família, do Governo Federal. Nesse sentido, esta pesquisa tem como objetivo principal refletir acerca da fome, da pobreza e do alcance do Programa Bolsa Família no Norte Pioneiro do Estado do Paraná. Além disso, espera-se avançar teoricamente acerca do conceito de fome e demonstrar a presença do Programa Bolsa Família na região, possibilitando comparar os dados de pobreza com os de beneficiários. Os procedimentos metodológicos foram: levantamento dos referenciais teóricos acerca da fome publicados por Josué de Castro; levantamento de dados de pobreza e de beneficiários do Programa Bolsa Família na região Norte Pioneiro do Paraná; e, por fim, elaboração de produções cartográficas e da redação final. O direito à alimentação é o direito a ter acesso regular e, permanente e livre, diretamente ou por meio de compras monetárias, a um alimento adequado e suficiente, porém, pode ser constatado que inúmeras pessoas no Norte Pioneiro do Paraná têm esse direito violado, convivendo com a fome e com a pobreza.
AS ARBOVIROSES E O SANEAMENTO BÁSICO
Authors: Aguiar da Silva Rafael , De Assis Barbosa Jane Roberta
Published: July 2020

Este artigo aborda a relação que se estabelece entre a presença ou ausência de saneamento básico e a ocorrência de arboviroses na cidade de Natal/RN. O estudo observou o número de casos registrados e a sua relação com as variáveis Cobertura de Esgotamento Sanitário, Resíduos Sólidos e Renda nas regiões administrativas. A coleta de dados secundários em órgãos nacionais, estaduais e municipais que lidam com a temática pesquisada, apoiada na produção de mapas temáticos, demonstrou que o maior número de casos de arboviroses ocorre nas Regiões Administrativas Norte e Oeste de Natal, onde, paralelamente há uma precária oferta de esgotamento sanitário. Nessas Regiões, verifica-se o acúmulo expressivo de resíduos sólidos e a menor renda mensal por pessoa, considerando as quatro regiões administrativas de Natal.

Palavras-chave: Saneamento Básico; Arboviroses; Gestão do Território; Natal/RN.
Enalos Suite of Tools: Enhancing Cheminformatics and Nanoinfor - matics through KNIME
Authors: Afantitis Antreas , Tsoumanis Andreas , Melagraki Georgia
Published: July 2020

Drug discovery as well as (nano)material design projects demand the in silico
analysis of large datasets of compounds with their corresponding properties/activities, as well
as the retrieval and virtual screening of more structures in an effort to identify new potent hits.
This is a demanding procedure for which various tools must be combined with different input
and output formats. To automate the data analysis required we have developed the necessary
tools to facilitate a variety of important tasks to construct workflows that will simplify the
handling, processing and modeling of cheminformatics data and will provide time and cost
efficient solutions, reproducible and easier to maintain. We therefore develop and present a
toolbox of >25 processing modules, Enalos+ nodes, that provide very useful operations within
KNIME platform for users interested in the nanoinformatics and cheminformatics analysis of
chemical and biological data. With a user-friendly interface, Enalos+ Nodes provide a broad
range of important functionalities including data mining and retrieval from large available databases
and tools for robust and predictive model development and validation. Enalos+ Nodes
are available through KNIME as add-ins and offer valuable tools for extracting useful information
and analyzing experimental and virtual screening results in a chem- or nano- informatics
framework. On top of that, in an effort to: (i) allow big data analysis through Enalos+
KNIME nodes, (ii) accelerate time demanding computations performed within Enalos+
KNIME nodes and (iii) propose new time and cost efficient nodes integrated within Enalos+
toolbox we have investigated and verified the advantage of GPU calculations within the
Enalos+ nodes. Demonstration data sets, tutorial and educational videos allow the user to easily
apprehend the functions of the nodes that can be applied for in silico analysis of data.
Voltammetric Analysis of Ephedrine in Pharmaceutical Dosage Forms and Urine Using poly(Nile Blue A) Modified Glassy Carbon Electrode
Authors: Ağın Fatma , Öztürk Gökçe , Kul Dilek
Published: July 2020

Objective:

The electrochemical analysis of ephedrine which is a sympathometric drug has been studied using poly(Nile blue A) modified glassy carbon electrodes, cyclic voltammetry, differential pulse voltammetry and square wave voltammetry.

Methods:

The modified electrodes were prepared by potential cycling electropolymerization of Nile blue A in 0.1 M phosphate buffer solution at pH 6.0. The redox behavior of ephedrine was investigated in different buffer solutions at pH values between 5.5 and 9.0.

Results:

Scan rate studies showed that the electron transfer reaction of ephedrine was diffusion controlled. A linear response was obtained between the peak current and the ephedrine concentration in the range of 0.6 to 100 μM with a limit of detection of 2.91×10-3μM for differential pulse voltammetry in Britton-Robinson buffer solution at pH 9.0. The linearity range of ephedrine in human urine was between 1.0 and 100 μM with a detection limit of 8.16 nM.

Conclusion:

The recovery studies in both pharmaceutical dosage forms and urine showed that the proposed method ensured good selectivity, precision and accuracy without any interference from inactive excipients.
Clinicopathological Significance of Long Non-Coding RNA GHET1 in Human Cancers: A Meta-Analysis
Authors: Poursheikhani Arash , Nokhandani Negin , Yousefi Hassan , Rad Dorsa M. , Sahebkar Amirhossein
Published: July 2020

Introduction:

Cancer is considered as the main public health problem and the second leading
cause of morbidity and mortality worldwide. Numerous environmental-lifestyle related risk factors
account for around one-third of cancer deaths. Recently, the key role of lncRNAs has been widely investigated
in a variety of disorders, including cancer. The lncRNA GHET1 has been considered as an
essential oncogenic lncRNA in many types of human cancers. Clinical investigations indicated that expression
of lncRNA GHET1 is correlated with clinicopathological characteristics in cancer. This metaanalysis
investigated the correlation between the lncRNA GHET1 expression and clinicopathological
features in different types of cancers.

Materials and Methods:

Comprehensive literature searches in PubMed, Scopus, and Web of
Knowledge were conducted up to April 11, 2019. Sixteen studies were included in this meta-analysis.
All statistical analyses were conducted using Stata software, version 12.0.

Results:

The pooled OR and 95%CIs of the sixteen relevant studies showed that over expression of
lncRNA GHET1 was associated with tumor-size ≥5 cm (OR= 2.51, 95% CI: 1.89-3.33, p=0.00,
I2=38.30%), positive lymph node metastasis (OR= 2.83, 95% CI: 1.78-4.52, p=0.00, I2=45.60%), advanced
tumor stage (OR= 3.92, 95% CI: 2.97-5.19, p=0.00, I2=0.00%), positive distant metastasis
(OR= 5.74, 95% CI: 2.58-12.77, p=0.00, I2=0.00%), advanced tumor status (OR= 2.97, 95% CI: 1.40-
6.29, p=0.01, I2=34.70%), and positive vascular invasion (OR= 2.69, 95% CI: 1.61-4.50, p=0.00,
I2=29.20%).

Conclusion:

Taken together, the current study demonstrated that overexpression of lncRNA GHET1 is
significantly associated with clinicopathological features in human cancers. Our results suggested that
lncRNA GHET1 can be utilized as a prognostic biomarker in human cancer.
Diagnosis Model of Hydrogen Sulfide Poisoning Based on Support Vector Machine
Authors: Ying Yifan , Jin Yongxi , Wang Xianchuan , Ma Jianshe , Zeng Min , Wang Xianqin
Published: July 2020

Introduction:

Hydrogen sulfide (H2S) is a lethal environmental and industrial poison. The mortality rate of
occupational acute H2S poisoning reported in China is 23.1% ~ 50%. Due to the huge amount of information on
metabolomics changes after body poisoning, it is important to use intelligent algorithms to mine multivariate interactions.

Methods:

This paper first uses GC-MS metabolomics to detect changes in the urine components of the
poisoned group and control rats to form a metabolic dataset, and then uses the SVM classification algorithm
in machine learning to train the hydrogen sulfide poisoning training dataset to obtain a classification
recognition model. A batch of rats (n = 15) was randomly selected and exposed to 20 ppm H2S
gas for 40 days (twice morning and evening, 1 hour each exposure) to prepare a chronic H2S rat poisoning
model. The other rats (n = 15) were exposed to the same volume of air and 0 ppm hydrogen
sulfide gas as the control group. The treated urine samples were tested using a GC-MS.

Results:

The method locates the optimal parameters of SVM, which improves the accuracy of SVM
classification to 100%. This paper uses the information to gain an attribute evaluation method to screen
out the top 6 biomarkers that contribute to the predicted category (Glycerol, -Hydroxybutyric acid,
arabinofuranose, Pentitol, L-Tyrosine, L-Proline).

Conclusion:

The SVM diagnostic model of hydrogen sulfide poisoning constructed in this work has training time and
prediction accuracy; it has achieved excellent results and provided an intelligent decision-making method for the diagnosis
of hydrogen sulfide poisoning.
Investigation of Cytotoxic Effects of Oxymetazoline on Lungs in a Rat Model of Rhinitis Medicamentosa
Authors: Cengiz Beyhan , Bostancıklıoğlu Mehmet , Demir Tuncer , Karabulut Hayriye , Dokuyucu Recep , Ulaşlı Mustafa
Published: July 2020

Background:

Rhinitis medicamentosa, also known as ‘rebound congestion,’ is inflammation
of the nasal mucosa caused by the overuse of topical nasal decongestants. Although local
decongestants resolve the initial nasal obstruction, the overuse causes rebound obstruction. However,
how the overuse of the decongestant causes rhinitis medicamentosa is not known.

Objectives:

Here, we show the intracellular effects of oxymetazoline, commonly used a local decongestant,
on the cell death pathways. We also investigated the antioxidative effects of erdosteine
suspension (175 mg/5mL), an antioxidative agent.

Methods:

Thirty Wistar-albino rats were used to form the rhinitis medicamentosa model. After
rhinitis medicamentosa was clinically detected, we removed the whole lungs of animals to perform
the molecular analyses of cell death pathways.

Results:

We found a statistically significant decrease in the expression levels of Atg5 (p=0.021),
Atg7 (p=0.013) and Ulk1 (p=0.036) in the oxymetazoline group compared to the control group
(p<0.05); however, Caspase 3 expression level was recorded to be significantly increased in the
oxymetazoline group, and the expression level of Beclin1 recorded to be substantially increased in
the erdosteine group (p=0.001).

Conclusion:

Based on these grounds, we suggest that vasoconstriction in capillary vessels caused by oxymetazoline could
lead to a decrease in the blood supply, which triggers autophagy to ensure cellular homeostasis.
A Pharmacological Review of Five Widely Used Traditional Medicinal Plants for Sedative-Hypnotic Effects in Bangladesh
Authors: Biswas Subir , Sutra Dhar Ananta , Rahman Mahbubur , Poly Khadija Akhter , Kabir Imonul
Published: July 2020

Medicinal plants are traditionally familiar to treat various physical abnormalities, diseases
and illnesses throughout the world A very large number of plant wealth has been offered by the
nature for all living organisms, which preserves medicinal excellence. Traditionally in the rural areas,
folk medicinal practitioners perform a more ordinary manner of medicine, where medicinal
plants constitute the foremost and most often only components of formulations. Geographical and
cultural factors of Bangladesh create an abundant source for herbal remedies. Nowadays, several
medicinal herbs having their hypnotic and sedative effects are thoroughly used in the treatment of
various psychiatric related disorders that include anxiety and insomnia. Sedatives are those types of
drugs which diminish the action, inducing a calming and relaxing outcome. Sedatives, in general,
produce sleep at higher doses. In recent years, the prevalence of psychiatric disorders which include
anxiety and insomnia is rising and therefore different researches are exploring to reveal better
medicine to treat these disorders. In this present review, we have performed a comprehensive literature
search to find out the five most frequently used medicinal plants with sedative effects for
the treatment of various disorders like anxiety and insomnia and their pharmacological activities in
scientific researches. The featured plants of this review articles are, Kaempferia galanga, Cleome
Rutidosperma, Kalanchoe pinnata, Calotropis gigantea, Scoparia dulcis L. In herbal and traditional
medicines, numerous plants are used without their scientific validation and we intend to carry
out a literature review in order to find out the effective scientific value of the featured plants. This
study will help to affirm the uses of these plants as traditional medicine and the researchers to detect
efficient therapeutic drugs according to their pharmacological studies.
Assessment of Direct and Indirect Current Control Techniques Applied to Active Power Filters
Authors: Adel Mohamed , Kandil Tarek
Published: July 2020

Background:

In this paper, an assessment of active power filter (APF) performance is
presented under direct and indirect current control schemes through on-line compensation theory.

Methods:

Conventional Direct Current Control (DCC) measures both load current and filter current
beside source and DC-link voltages, while Indirect Current Control (ICC) measures only source current
beside voltage measurements. Both DCC and ICC control algorithms are implemented using
80C196KC low-cost microcontroller.

Results:

The performance parameters of APF are compared under two methods, and it is assigned
that ICC gives a better performance with lower cost due to reduced number of sensors. The DC-link
output voltage is controlled through simple PI-controller, and the PWM switching signals required
by APF power circuit is obtained by hysteresis current controller.

Conclusion:

The comparative simulation and experimental results exhibit that performance of APF
due to ICC scheme is superior than DCC one.
Ateroskleroz ile İlişkili Hematolojik Parametrelerin Obezite ile İlişkisinin Değerlendirilmesi
Authors: PAŞALI KİLİT Türkan , KURTOĞLU Yasemin , KİLİT Celal , KOÇAK Fatma , GENÇ Özlem
Published: July 2020

Giriş: Çalışmanın amacı, obezite parametreleri ile ateroskleroz ile ilişkili olduğu gösterilen hemogram parametrelerinden ortalama trombosit hacmi (MPV), nötrofil-lenfosit oranı (NLO) ve platelet-lenfosit oranı (PLO) arasındaki ilişkinin değerlendirilmesidir. Yöntem: Çalışmaya İç Hastalıkları polikliniğine başvuran 240 birey alındı. Bireyler vücut-kitle indekslerine göre gruplandırıldı. Obez olan bireyler de kendi içinde sınıf I, sınıf II ve sınıf III obezite olarak 3 gruba ayrıldı. Bulgular: Çalışmaya 182 kadın ve 58 erkek hasta dahil edildi. Yaş ortalaması 45,4±13,0 yıl, vücut-kitle indeks ortancası 31,4 (26,2–36,5) kg/m2 idi. Vücut-kitle indeks ile hemoglobin (r=-0,168, p=0,009) ve hematokrit (r=-0,188, p=0,003) değerleri arasında negatif, vücut-kitle indeks ile MPV (r=0,186, p=0,004) arasında ise pozitif korelasyon bulundu. Kilo ile PLO arasında negatif korelasyon bulundu (r=-0,143, p=0,027). Kalça çevresi ile MPV arasında pozitif korelasyon bulundu (r=0,155, p=0,016). Vücut-kitle indeks, kilo, bel çevresi ve kalça çevresi ile diğer hematolojik parametreler arasında anlamlı bir ilişki bulunamadı. Vücut-kitle indeks ≥30 kg/m2 olan grupta, hemoglobin ve hematokrit değerleri daha düşük, MPV değerleri ise daha yüksek olarak bulundu (sırasıyla p=0,007, p=0,002, p=0,009). MPV değerleri, sınıf II ve III obezite gruplarında, sınıf I obezite grubuna göre daha yüksek bulundu. Sonuç: MPV ve PLO değerleri, antropometrik ölçümlerle korelasyon göstermektedir. Vücut-kitle indeks arttıkça hemoglobin ve hematokrit değerleri azalmaktadır.
Remote Care for Caregivers of People With Psychosis: Mixed Methods Pilot Study
Authors: Romm Kristin Lie , Nilsen Liv , Gjermundsen Kristine , Holter Marit , Fjell Anne , Melle Ingrid , Repål Arne , Lobban Fiona
Published: July 2020

Background

A reduced availability of resources has hampered the implementation of family work in psychosis. Web-based support programs have the potential to increase access to high-quality, standardized resources. This pilot study tested the Norwegian version of the Relatives Education and Coping Toolkit (REACT), a web-based United Kingdom National Health Service program in combination with phone-based support by trained family therapists.

Objective

We investigated how the program was perceived by its users and identified the facilitators and barriers to its clinical implementation.

Methods

Relatives of people with psychosis were offered access to REACT and to weekly family therapist support (with 1 of 2 trained family therapists) for 26 weeks. Level of distress and level of expressed emotion data were collected at baseline and after 26 weeks using the Family Questionnaire and the Relatives Stress Scale. Both family therapists and a subset of the relatives were interviewed about their experiences after completing the program.

Results

During the program, relatives (n=19) had a median of 8 (range 4-11) consultations with the family therapists. Postintervention, there was a significant reduction in stress and in expressed emotions in the relatives of people with psychosis. Interviews with the relatives (n=7) and the family therapists (n=2) indicated the following themes as important—the intervention turned knowledge into action; the intervention strengthened the feeling of being involved and taken seriously by the health services; and management support and the ability for self-referral were important, while lack of reimbursement and clinician resistance to technology were barriers to implementation.

Conclusions

The service was found to offer a valued clinical benefit; however, strategies that aim to engage clinicians and increase organizational support toward new technology need to be developed.
EFFECT OF POLYMER-INDUCED LIQUID PRECURSOR PROCESS CONTAINING POLYASPARTIC ACID ON INTRAFIBRILLAR DENTIN REMINERALIZATION (MICRO-COMPUTED TOMOGRAPHY ANALYSIS)
Authors: AVANTI NORMA , DJAUHARIE NILAKESUMA , MARGONO ANGGRAINI , MEIDYAWATI RATNA , THYSA CUT
Published: July 2020

Objective: Caries treatment can be performed by minimal intervention, i.e., by removing the infected dentin and leaving the affected dentin and theninducing remineralization in the affected dentin. The affected dentin still consists of collagen cross bonds. Polymer-induced liquid precursor processis a guided tissue remineralization method that aims to remineralize intrafibrillar and extrafibrillar dentin by adding polymers that are similar tonon-collagen protein. One of the non-collagen protein analog materials is polyaspartic acid. The aim of this study was to evaluate the remineralizationof dentin on the demineralized dentin surface after immersed in remineralization solutions containing polyaspartic acid as a non-collagen proteinanalog.Methods: Human premolar teeth extracted for orthodontic purposes were divided into four groups, namely, one control and three treatment groups.Teeth in the control group were immersed only in the demineralization solution containing acetate buffer (pH 5.0, 66 h). Teeth in the three treatmentgroups were immersed in acetate buffer (pH 5.0, 66 h) and then continue to immersed in the remineralization solution containing polyaspartic acidfor 3, 7, and 14 days. Remineralization was evaluated by micro-CT.Results: Remineralization appeared on the demineralized dentin surface, characterized by an increase in the grayscale index, after immersion inthe remineralization solution containing polyaspartic acid. Significant differences were observed in the mean grayscale index values among the fourgroups.Conclusion: Polyaspartic acid has the potential to induce dentin remineralization.
EFFECTS OF COLD LATERAL VERSUS WARM VERTICAL COMPACTION OBTURATION ON THE PUSH-OUT BOND STRENGTH OF BIOROOT™, A CALCIUM SILICATE-BASED SEALER
Authors: PUTRIANTI ANDARI , USMAN MUNYATI , NAZAR KAMIZAR , MEIDYAWATI RATNA , SUPRASTIWI ENDANG , MAHARDHINI SWESTY
Published: July 2020

Objective: BioRoot™ , which contains pure calcium silicate, is used in cold lateral compaction. However, hydroxyl ions are still released when BioRoot™is used in warm vertical compaction. This study compared the effects of cold and warm vertical compaction obturation on the push-out bond strengthof BioRoot™.Methods: Specimens from 16 root canals instrumented with ProTaper Next X5 50/06 were divided into two groups (n=16 specimens per group).Group 1 was obturated using cold lateral compaction, whereas Group 2 was obturated using warm vertical compaction. All samples were incubatedfor 48 h (37°C, 100% humidity) and embedded into an acrylic block. Starting at 7 mm from the apex, two 2-mm-thick slices of each sample were cut.Dislodgement resistance was measured using a universal testing machine, and the push-out bond strength was calculated.Results: There was a significant difference in the push-out bond strength value between cold (4.5–41.1 MPa) and warm (4.12–24.25 MPa) compactionobturation (p<0.05).Conclusion: Cold lateral compaction provides better adhesion capability than warm vertical compaction in root canal obturation.
ANALISIS PERBANDINGAN KEBIJAKAN PENYELESAIAN PERKARA PIDANA DI LUAR PERSIDANGAN DI BELANDA, INGGRIS, DAN INDONESIA
Authors: Zunaidi Ahmad Hajar , Najih Mokhammad
Published: July 2020

Tindak pidana yang bersifat ringan harus diselesaikan dengan mekanisme yang sama seperti tindak pidana yang berat, adalah salah satu bentuk ironi keadilan. Untuk mengurangi persoalan ironi keadilan tersebut, beberapa negara telah mengembangkan berbagai mekanisme penyelesaian perkara di luar persidangan untuk perkara-perkara yang bersifat ringan. Selain itu,  sistem peradilan pidana di setiap negara secara umum juga hanya mampu memproses sebagian kecil dari seluruh  tindak pidana yang terjadi sehingga penuntut umum harus melaksanakan diskresi dalam memutuskan perkara mana yang akan dilanjutkan atau dihentikan penuntutannya atau diselesaikan dengan mekanisme penyelesaian perkara pidana yang bersifat ringan di luar persidangan. Isu hukum yang dianalisis dalam tulisan ini adalah bagaimana ratio legis pengaturan mekanisme penyelesaian perkara pidana di luar persidangan di Belanda dan Inggris. Hasil dari analisis tersebut adalah ratio legis pengaturan penyelesaian perkara pidana di luar persidangan adalah untuk mewujudkan keadilan melalui penyederhanaan sistem peradilan pidana dan penerapan asas kelayakan. Keadaan berbeda terjadi pada sistem peradilan pidana Indonesia karena sangat tidak efisien, tidak sesuai dengan asas peradilan cepat, sederhana, dan biaya ringan. Berdasarkan kesimpulan  diatas, maka dapat disampaikan  rekomendasi bahwa asas kelayakan perlu segera diterima dalam sistem peradilan pidana di Indonesia dengan cara mengadopsi teori subsosialitas sebagaimana tercantum dalam Pasal 9a Sr. dan mengadopsi mekanisme penyelesaian perkara tindak pidana yang bersifat ringan di luar persidangan dalam bentuk transaksi dengan model komposisi, dengan disertai adanya modifikasi penambahan pokok-pokok pemikiran adaptasi bagi sistem hukum Indonesia.Keywords: penyelesaian; perkara; pidana
EKSISTENSI PENGADILAN AGAMA PASCA PENYATUAN SATU ATAP (INDEPENDENSI DAN PENGEMBANGANNYA)
Authors: Candra Mardi
Published: July 2020

(The abstract should not exceed 250 words. It should briefly summarize the essence of the paper and address the following areas without using specific subsection titles.): Objective: Briefly state the problem or issue addressed, in language accessible to a general scientific audience. Technology or Method: Briefly summarize the technological innovation or method used to address the problem. Results: Provide a brief summary of the results and findings. Conclusions: Give brief concluding remarks on your outcomes. Clinical Impact: Comment on the translational aspect of the work presented in the paper and its potential clinical impact. Detailed discussion of these aspects should be provided in the main body of the paper.
Rational emotive therapy pada permasalahan hubungan sosial
Authors: Purnamasari Yulia
Published: July 2020

Subjek seorang laki-laki berusia 20 tahun dengan keluhan sering merasa sedih hingga menangis, saat ada masalah dengan teman dekat. Asesmen yang digunakan pada Subjek adalah wawancara, observasi, tes grafis (DAP, BAUM, HTP) dan tes SSCT. Hasil asesmen, Subjek memiliki pemikiran irasional terkait dengan hubungan sosial, Subjek berpikiran bahwa dirinya tidak sepemahaman dengan teman-temanya, dan Subjek hanya memiliki satu teman dekat dan sering merasa iri dan cemburu saat teman dekatnya tersebut dekat dengan orang lain. Intervensi yang diberikan adalah rational emotive therapy yang disusun sebanyak 6 sesi. Tujuan intervensi yaitu untuk mengubah pemikiran irasional (Subjek berpikiran bahwa teman-teman tidak satu pemahaman dengan dirinya, berpikir bahwa hanya bisa berteman dengan satu orang, Subjek berpikir saat mencoba bergabung dengan teman pasti akan terjadi perkelehaian, dan saat memiliki teman dekat takut kehilangan) menjadi rasional sehingga Subjek dapat menjalin hubungan sosial yang lebih baik. Hasil intervensi, Subjek dapat mengembangkan dan memunculkan pemikiran irasional/positif untuk menggantikan pemikiran dan keyakinan irasional agar Subjek tidak lagi mengalami masalah emosional, Subjek saat ini membuka diri dengan sosialnya dan fokus menyelesaikan tugas-tugas perkuliahan.
Formação de professores baseada na investigação pedagógica
Authors: Vieira Flávia , Silva José Luís Jesus Coelho da , Vilaça Maria Teresa Machado
Published: July 2020

O artigo apresenta um estudo sobre o modelo de estágio dos Mestrados em Ensino da Universidade do Minho (Portugal), criados com a reforma de Bolonha. O modelo confere um lugar central ao desenvolvimento de um projeto de investigação pedagógica na escola, apresentado num relatório final defendido em provas públicas. O estudo envolveu a análise qualitativa de 40 relatórios de estágio e um inquérito por questionário respondido por supervisores da universidade (n=34), orientadores cooperantes das escolas (n=112) e ex-estagiários (n=133). São apresentados resultados relativos à natureza e impacto dos projetos e às competências profissionais evidenciadas nos relatórios. Conclui-se que as perceções dos participantes e os relatórios estão globalmente alinhados com pressupostos e linhas de ação do modelo, embora se identifiquem algumas limitações que apontam a necessidade de melhorias nos processos de formação.
Improving the quality of Portuguese SMEs through competence evaluation
Authors: Garcia Ana C.M. , Silva Maria C.V.
Published: July 2020

Problem and goal. Since we are going through a key moment in terms of technological advances and their effect on the labour field, the investigation of the on-the-job training processes gains a predominant role. Moreover, the need to research an approach that promotes a balance between the four spheres of development of learning - economic, sustainable, community and personal - is emerging. This study was conceived as a result of this urgency, aiming to respond to the following problem: to what extent does a training model, based on the VPL (Validation of Prior Learning) approach and supported by principles of the educational sciences, can contribute to individual empowerment and, consequently, to an improvement in the organizational quality of Portuguese SMEs (Small and Medium-sized Enterprises)? Methodology. The division of the research into two parts - Study 1 and Study 2 - allowed the collection and analysis of structural data (Study 1) that served as a basis for the definition of a dynamic strategy (Study 2). Although undertaken at different times, they have thus proved to be complementary. In fact, the design of the training model was based, firstly, on the results obtained through exploratory interviews with key informants and, secondly, on the data obtained throughout the training process that involved ninety-two employees from ten Portuguese SMEs from diverse categories and sectors. Results. The training model, which emerged from the interaction between the theoretical reflection and the practical context, comprises five components: distance learning, recognition of skills, language skills, intercultural skills and an individual action plan. Conclusion. This study, being an important contribution to the topic of on-the-job training in Portuguese SMEs, at the same time opens the way for the continuation of the research.
Kinematic support modeling in Sage
Authors: Kroytor Oleg K. , Malykh Mikhail D. , Karnilovich Sergei P.
Published: July 2020

The article discusses the kinematic support, which allows reducing the horizontal dynamic effects on the building during earthquakes. The model of a seismic isolation support is considered from the point of view of classical mechanics, that is, we assume that the support is absolutely solid, oscillating in a vertical plane above a fixed horizontal solid plate. This approach allows a more adequate description of the interaction of the support with the soil and the base plate of the building. The paper describes the procedure for reducing the complete system of equations of motion of a massive rigid body on a fixed horizontal perfectly smooth plane to a form suitable for applying the finite difference method and its implementation in the Sage computer algebra system. The numerical calculations by the Euler method for grids with different number of elements are carried out and a mathematical model of the support as a perfectly rigid body in the Sage computer algebra system is implemented. The article presents the intermediate results of numerical experiments performed in Sage and gives a brief analysis (description) of the results.
OCCLUSAL SPLINTS: TYPES, MATERIALS AND PROPERTIES - A LITERATURE REVIEW
Authors: Araújo de Souza Julia , Da Veiga Kalil Marcos , Alves da Cunha Kalil Maria Theresa
Published: July 2020

ABSTRACT                    Temporomandibular Disorder (TMD) is considered the major cause of non-dental pain in the orofacial region and the most crucial symptom for which patients seek medical attention, negatively affecting quality of life. The plates have gained prominence as a treatment for TMD but the success or failure of the occlusal plates will depend on their correct selection and indication, materials for making and adjusting, in addition to the cooperation of the patient. The purpose of this study is to highlight the most used types of occlusal plaques, their advantages, disadvantages, indications and contraindications, in addition to identifying and analyzing the materials currently used in their manufacture. A literature review was conducted with searches on articles from the electronic databases PubMed, Virtual Health Library (BVS) and Google Scholar with the descriptors: disfunção, placa occlusal, tratamento, dysfunction, plate, occlusal and treatment. We also use bibliographic information from Okeson (2013). From the data collected in this literature review, it can be concluded that the occlusal plaque is considered a conservative and reversible method and has stood out for its low cost and high success rate. This study demonstrated that the most advantageous material for the manufacture of the plates was the photopolymerizable resin. However, the dentist must be attentive to a correct diagnosis, selection and indication, preparation and adjustment materials, in addition to the patient's cooperation in order to provide the appropriate treatment.
Dampak Reklamasi Pantai Boulevard Terhadap Kesejahteraan Rumah Tangga Nelayan Di Kota Manado Provinsi Sulawesi Utara
Authors: Dahyar Daraba  , Ribka Christy  , Clara Saroinsong
Published: July 2020

Pembangunan reklamasi pantai diharapkan mampu memenuhi kebutuhan daerah serta dapat menjawab permasalahan pembangunan daerah dalam meningkatkan pertumbuhan ekonomi untuk kesejahteraan masyarakat.. Tujuan dari penelitian ini untuk mengetahui dan menganaslisis dampak reklamasi pantai Boulevard terhadap kesejahteraan rumah tangga nelayan di kota Manado, untuk mengetahui sejauh mana upaya pemerintah menganggapi pola perubahan pekerjaan nelayan akibat reklasmasi pantai, untuk mengetahui harapan nelayan terhadap reklamasi pantai Boulevard. Metode Penelitian yang digunakan yaitu metode penelitian kualitatif deskriptif dengan ruang lingkup penelitian yakni jaminan social, kesehatan, pendidikan, perumahan, pekerjaan social, ketenagakerjaan, ekonomi masyarakat, rekreasional, spiritualitas dan lingkungan hidup. Adapun informan sebanyak 19 orang, dengan teknik pengumpulan data wawancara,observasi dan dokumentasi. Teknik keabsahan data yang digunakan yakni triangulasi. Sedangkan teknik analisis data yakni reduksi data, penyajian data dan penarikan kesimpulan. Berdasarkan hasil penelitian tingkat kesejahteraan rumah tangga nelayan di Kota Manado cukup baik, adanya kawasan reklamasi sebagai pusat perdagangan memberikan peluang kepada masyarakat untuk berinovasi dalam dunia perdagangan dan pemerintah lebih memperhatikan masyarakat nelayan sebagai pihak yang paling merasakan dampak reklamasi
A Conceptual Framework on the Audit Quality in the Government Internal Audit in Indonesia
Authors: Aswar Khoirul , Ermawati  , Wiguna Meilda , Hariyani Eka
Published: July 2020

This study begins with the problem of auditor performance on the Big Four Public Accounting Firm and requires an improvement in audit quality due to a decreased audit quality assessment on the Big Four Public Accounting Firm. Problem related to audit quality is also experienced by government internal auditors. This is due to several factors such as the minimum standards set by the Financial and Development Supervisory Agency (FDSA) that have not been met by government internal auditors, auditor staff with accounting education backgrounds are still very few, auditors have not applied the Government Internal Oversight Apparatus (GIOE) code of ethics and so forth. The aims of this study to determine the extent of the audit quality produced by the government's internal auditors at the FDSA of Java island Representatives. Through the theory of behaviorism, this study has four objectives is to find out the implementation of professional accounting ethics, auditor competence, integrity, professional commitment on audit quality. Therefore, this study contributes to FDSA of Java Provinces to carry out the functions and duties of government internal auditor based on the GIOE codes and ethics and standards.