bluuebunny/crossref_metadata_2025 huggingface dataset:
Significados de la actividad física en la cotidianidad. Los lugares de la belleza y el placer en una práctica de salud
Authors: Hormiga Sánchez, PhD Claudia Milena , Alzate Posada, PhD Martha Lucía , Cortés-García, PhD Claudia Margarita
Published: August 2019

Introducción: la visión de la actividad física como experiencia cotidiana, determinada en parte por la organización social, es importante para entender y promover su práctica, dados los beneficios en salud que conlleva. Se realizó un estudio cualitativo interpretativo enfocado en los significados de la actividad física y su práctica en la cotidianidad de hombres y mujeres de Santander. Participaron 20 mujeres y 21 hombres, escogidos a partir de un muestreo teórico. Desarrollo: la actividad física se entiende como, principalmente, como el movimiento corporal que requiere de esfuerzo superior al del diario vivir, el cual constituye un medio para cuidar la salud y lograr un cuerpo ‘normal’. Se trata también de una práctica generizada, que generiza la apariencia y es fuente de placer para sus practicantes. Conclusiones: en los significados de la actividad física, se observan elementos de las recomendaciones poblacionales sobre actividad física y el enlace entre el peso corporal ‘normal’, la salud y la belleza, conceptos alimentados por el discurso biomédico según el cual el riesgo de enfermar es una consecuencia de las elecciones que hacen las personas sobre su estilo de vida. Estas nociones coexisten con otras sobre la actividad física y el cuerpo, las cuales trazan una ruptura entre el significado de la actividad física y su práctica. A partir de estas, se dilucida un aspecto central del proceso reflexivo detrás de la práctica de actividad física: la conciencia corporal que motiva y acompaña su práctica, en parte proporcionada por el placer que produce la experiencia corporal íntima de la actividad física.
“Es rico hacerlos, pero no tenerlos”: análisis de la violencia obstétrica durante la atención del parto en Colombia
Authors: Vallana Sala, MSc Viviana Valeria
Published: August 2019

Introducción: se analizan, desde una perspectiva feminista, algunas formas de maltrato y violación de los derechos humanos, sexuales y reproductivos de las mujeres durante la atención del embarazo y parto, fenómeno conocido como violencia obstétrica. Desarrollo: se analizan las historias de embarazo/parto de seis mujeres que parieron sus hijos/as en instituciones hospitalarias, tanto públicas como privadas, así como la autoetnografía de los dos embarazos/partos de la autora, para analizar las maneras en las que las mujeres describen y dan sentido a sus experiencias de violencia obstétrica durante la atención de su parto. En el artículo, se visibilizan las diversas formas de violencia que componen la violencia obstétrica, como institucional, física, verbal, psicológica y simbólica. Conclusiones: se aportan algunos elementos que, a juicio de las mujeres y de la Organización Mundial de la Salud, deben transformarse para garantizar un trato digno y el derecho a un parto y nacimiento en condiciones de respeto y seguridad.
Inhalation sedation – looking forward to the digital age
Authors: Pickles Janet
Published: August 2019

As we progress into the 21st century, Janet Pickles suggests it is good to reflect on the origins of the modern inhalation sedation (or relative analgesia) machine
Bare all?
Authors: Russell Meredith Jones
Published: August 2019

How one setting in West Sussex is encouraging the children to go barefoot outside. Meredith Jones Russell reports
A missing link?
Authors: Arnold Cath
Published: August 2019

‘Action schemas’ are reflected in young children's emerging language, explains Dr Cath Arnold, using observations of three children in conversation
Effect of fertilizer-N and organic resource management on soil aggregates formation and carbon cycling in the central highlands of Kenya
Authors: NJOROGE KINYANJUI SAMUEL , NJIRU DANIEL MUGENDI , VANLAUWE BERNARD
Published: August 2019

Njoroge KS, Mugendi DN, Vanlauwe B. 2018. Effect of fertilizer-N and organic resource management on soil aggregates formation and carbon cycling in the central highlands of Kenya. Asian J Agric 2: 25-37. To inquire the way the alteration of soils of various textures and fertility values with fertilizer-N and organic resources influencing aggregate formation and subsequent carbon (C) cycling in aggregates became the objective of this research. The experiment was carried out in Embu and Machang'a regions of central Kenya and was rooted on a putrefaction tube experiment that was established in April 2005. This experiment was intended at completing long-term field experimentations initiated in 2002 to set up the impact of the application of various combinations of organic and mineral resources on soil nutrient status. The main variables were fertilizer-N and organic resources, with the sub-management being soil fertility values. Maize stover and urea fertilizer were mixed with 3.2 kg of soil and put in putrefaction tubes. The implementation rate was 4 ton and 120 kg per hectare for the maize stover and fertilizer respectively. Four management were developed, namely: control (no organic resources or fertilizer-N added), lone fertilizer-N, lone stover, and combined stover and fertilizer-N, with each management having three replicates. To decide the alterations in soil aggregates, dirt samples acquired from the putrefaction tubes were fractionated through wet sieving. SOM fractionation was also carried out to gain the various SOM fractions. All achieved aggregates and SOM fractions were then dried in the oven, ground, and analyzed for C. All collected data were examined with the PROC MIXED procedure of SAS and the means separated at p <0.05. Bigger quantity of macroaggregates from Embu soils was studied than that from Machang'a soils. For both Embu and Machang'a soil, the alteration of soils with lone or combined fertilizer-N and organic resources had a notable impact (p <0.05) on the portions of all aggregate class sizes. The alteration of soils of various fertility values with lone or combined fertilizer-N and organic resources also had a notable impact on the allocation of SOM fractions for both Embu and Machang' soils. Remarkable discrepancies in whole soils, aggregates and SOM fractions percentage carbon values were also studied. On the whole, the silt and clay fraction had higher C values than that in other aggregate size classes representing higher stabilization of C within this fraction. From the results of this research, it is concluded that the utilization of combined organic and mineral resources is preferred for the enhancement and the preservation of soil fertility in high fertility soils. In low fertility coarse-textured soils, the lone implementation of organic resources is suggested for the enhancement and the preservation of soil fertility.
The study of childhood: thoughts from a family life researcher
Authors: Brannen Julia
Published: August 2019

These reflections are based on my role as a family sociologist for over 40 years whose work has consistently included children in its gaze and has embraced families as wider social networks and intergenerational relations. It discusses the rise of childhood studies as a distinctive field and how it engages, and needs to engage, with other social domains and fields of research.
ESTRATÉGIAS FORMATIVAS PARA O DESENVOLVIMENTO PROFISSIONAL: ANÁLISE DE UM PROJETO DE FORMAÇÃO CONTINUADA DE PROFESSORES(AS) DE EDUCAÇÃO FÍSICA
Authors: Nadolny Lorena De Fatima , Garanhani Marynelma Camargo
Published: August 2019

O presente texto discute o desenvolvimento profissional de professores(as) de Educação Física. Para isso, toma como referência uma pesquisa de Doutorado em Educação que investigou como as estratégias formativas estruturaram o desenvolvimento profissional de professores(as) de Educação Física participantes de um projeto de formação realizado por meio de uma parceria entre a Universidade Federal do Paraná (UFPR) e a Secretaria Municipal de Educação (SME) de Curitiba. Os procedimentos metodológicos envolveram análise documental e entrevistas com professores(as) de Educação Física da Rede Municipal de Ensino (RME) de Curitiba que participaram do referido projeto. A análise interpretativa dos dados foi realizada com base na teoria da relação com o saber de Charlot e mostrou que as estratégias formativas oportunizaram relações epistêmicas e identitárias com o saber/aprender, as quais se refletiram em aprendizagens e desenvolvimento profissional. O sentido dado ao processo de formação continuada e às situações vividas nele por meio das estratégias formativas é que mobiliza o desejo do(a) professor(a) de aprender. E é aprendendo que o(a) professor(a) se desenvolve profissionalmente. Frente a essas constatações e considerações, na formação continuada as estratégias formativas estruturam o desenvolvimento profissional de professores(as), pois agem como fontes de mobilização para o saber/aprender.
CONTENIDO ESENCIAL Y PONDERACIÓN DE LOS DERECHOS FUNDAMENTALES: DE LOS MODELOS RECÍPROCOS Y COMPLEMENTARIOS
Authors: Espinoza José Luis Leal , Sánchez Rogelio López
Published: August 2019

Los modelos más relevantes según la doctrina especializada enargumentación constitucional para resolver conflictos y asignar significado a los Derechos Fundamentales son la teoría del contenido esencial y el modelo de la ponderación. Para el primer modelo, la concreción de normas de Derechos Fundamentales proviene de una determinación previa, asignada por el legislador, en tanto que el segundo modelo defiende una postura a través de la cual la concreción de un derecho fundamental proviene de los límites externos cuando éstos se encuentran en conflicto con otros, en aras de su plena realización. Nuestro objetivo consiste en demostrar que a pesar de que existe una aparente dicotomía entre ambos, éstos se complementan, cuando el juez asigna significado y concreta la deontología contenida en las Cartas Constitucionales.
QUALIDADE DA ÁGUA: UM ENFOQUE JURÍDICO E INSTITUCIONAL DO REÚSO INDIRETO PARA FINS POTÁVEIS
Authors: Granziera Maria Luiza Machado
Published: August 2019

O artigo trata do reúso indireto não planejado de água para fins potáveisno Brasil, tema associado à qualidade e à gestão dos recursos hídricos. O estudo parte de uma análise das normas sobre qualidade da água, abordando a realidade da diluição de efluentes domésticos à luz das normas vigentes. O objetivo é demonstrar a importância da articulação institucional e da governança entre União, Estados e Municípios na solução dos problemas da poluição da água causada pelos esgotos domésticos. A metodologia constitui-se de pesquisa exploratória e qualitativa, utilizando bibliografia baseada em doutrina, princípios e normas relacionadas ao assunto. Concluiu-se que uma forma adequada de enfrentar o problema consiste na articulação entre o planejamento das bacias hidrográficas e os planos municipais de saneamento básico, grande desafio para os atores envolvidos no processo.
DESAFIOS DA REGULAÇÃO TRIBUTÁRIA EM TEMPOS DE TECNOLOGIAS DISRUPTIVAS
Authors: Payão Jordana Viana , Rossignoli Marisa
Published: August 2019

O objetivo do presente trabalho é a análise dos desafios da regulaçãotributária em tempos de tecnologias disruptivas. Questiona-se se há pertinência tributária in casu e, caso afirmativo, quais as consequências da tributação? O ordenamento jurídico vigente prevê regulação adequada e passível de incidência? Como reagirá o contribuinte em face das imposições tributárias? Como alcançar um nível ótimo de tributação, aliando eficiência aos demais princípios tributários? Para responder às questões postas, o estudo é desenvolvido sob a perspectiva da análise econômica do Direito (Law and Economics) desenvolvida por RichardPosner, aliado à Teoria dos Sistemas de Niklas Luhmann, de modo a permitir uma visão interdisciplinar e complexa da temática, aliado à pesquisa bibliográfica nacional e estrangeira, utilizando-se o método dedutivo como base da pesquisa. Dentre os possíveis caminhos, destacam-se a regulação em novos moldes, a autorregulação, a adaptação do ordenamento jurídico vigente e a adaptação aos novos contornos da economia disruptiva.
Processing and Analysis of Condensation Trails Data Using Database Systems
Authors: Vidoň Václav , Lán Sébastien
Published: August 2019

This article describes the causes and behavior of aircraft condensation trails, aircraft radar technology, communication between aircraft and ground control stations, description of the function, analysis and processing of the ADS-B receivers and registers data. It also deals with the design and creation of a suitable web application with a simple user interface and a database for storing and processing this data. The work was based mainly on academical materials and sources, focusing on the issue of condensation trails, ADS-B functionality and programming of web applications.
Prognostic value of somatic mutation testing and different methods of treatment of low-risk differentiated thyroid cancer
Authors: Kachko Vera A. , Vanushko Vladimir E. , Platonova Nadezhda M.
Published: August 2019

Background: Using molecular testing for prediction the course of the disease could possibly help doctors in making therapeutic decisions about the management of patients, because it remains controversial issues in low-risk differentiated thyroid cancer patients. The experts opinions are different on the volume of treatment of these patients: the adequacy of hemitireoidectomy, the need to remove the lymph nodes of the central zone (level VI) and the need for radioiodine therapy.
Aims: to evaluate the frequency of recurrences in different complex treatment options of low-risk differentiated thyroid cancer; to evaluate the frequency of somatic mutations in the hot spots of BRAF, KRAS, KRAS, EIF1AX and TERT genes in histological material and to evaluate their prognostic value.
Materials and methods: A prospective, observational, cohort, sample, single-center, open-label, controlled, nonrandomized clinical trial was performed, which included patients with the thyroid neoplasms, recruited in the period from 2012 to 2014. Samples of histological material were tested for the presence of somatic mutations in hot spots of the genes BRAF, KRAS, NRAS, TERT, and EIF1AX. After the treatment, the low-risk differentiated thyroid cancer patients group were observed for 4368 months.
Results: The study included 90 patients with low-risk well differentiated thyroid cancer. Mutations in the hot spots of the BRAF gene (exon 15, codon area 600-601) were found in 53 patients, mutations in the hot spots of the NRAS gene (exon 3, codon 61) in 3 patients; mutations in the hot spots of the KRAS, TERT and EIF1AX genes were not detected. The median follow-up in the well differentiated thyroid cancer group was 56 months. Recurrence diagnosed in 12 patients (13.3%), significant differences in the frequency of recurrence depending on the surgical treatment option was not revealed, significant differences in the frequency of recurrence between the groups BRAF+/BRAF was not revealed.
Conclusions: Low-risk well differentiated thyroid cancer patients have characterized a very favorable the course of disease and prognosis, even in the case of recurrence. In this study, complex treatment has not shown significant advantages over thyroidectomy in treating patients with thyroid microcarcinomas. Mutation testing of histological material in hot spots of genes BRAF, KRAS, NRAS, EIF1AX and TERT cant be used as an additional marker in low-risk well differentiated thyroid cancer patients to predict the course of the disease, although the lack of detection of aggressive genes of the disease may indicate a favorable prognosis in these patients.
Appearances of Disability and Christianity in Uganda
Authors: Zoanni Tyler
Published: August 2019

This article considers how Christianity contributes to the appearance of cognitive disability in Uganda, a country with some of the most progressive disability policies in the world but little in the way of formal care and advocacy for cognitively disabled people. As a point of departure, the article invokes Hannah Arendt’s notion of appearance as a way to thematize the importance of public display in Ugandan social life, as well as the challenge that people with evidently profound disabilities pose to Ugandan social aesthetics. It first traces how cognitive disability disappears under the liberal logics that organize Uganda’s secular disability laws and activism, and then compares the ways that Catholic and Pentecostal efforts sustain the appearance of cognitive disability, in light of their theological differences and their common paternalism. Even as Christian paternalism in the face of cognitive disability may prove repugnant to a liberal vision of disability politics, I argue that it sustains a form of disability appearance otherwise not possible in Uganda.

Bufunze

Ekiwandiiko kino kilagira ddala bulungi, nga obukristaayo bwe bwewaddeyo ennyo ku nsonga etekwatiddwa bulungi ey’endabika y’abantu abalina obulemu mu butesobola nga buva ku bwongo nga bali mu Uganda. Eggwanga erya Uganda lirina enkola ennungi mu byokwezza obuggya ku nsonga y’abantu abo munsi yonna. Wabula ate kinakuwaza nnyo, nti libulamu nnyo enkola ennungamu mu ngeri y’okuwagira endabirira esaanidde abantu abo, mu mbeera zaabwe zonna okutwalira awamu. Ekiwandiiko kino okwawukana ku bya bulijjo ebirala byonna, kikoona butereevu ku ndowooza ya Hannah Arendt, era nga kirina n’okulaga okusomooza okuleteddwaawo obutafa bulungi ku bantu abo mu mbeera zaabwe mu ggwanga lyonna. Ekiwandiiko kisookera ddala n’okulaga engeri y’okufaayo ku nsonga eyo bwe kigenda kisaanirawo ddala nga kino kiyita mu kwekkiriranya abantu kwe batambuliramu ng’abakweyambisa, nga bakola amateeka agakwata ku butesobola obw’obwongo, wamu nebirala ebikolebwa okukisaamu amaanyi, Kati ekyo, nga bwe twongerako netukigeerageeranya n’ekyo ekikolebwa abakatuliki n’aba Pentekooti ku nsonga eyo yemu mu kuyimirizaawo endabika entuufu eyandisaanidde ku bantu abo abalina obulemu bwobutesobola. Naye ate olwokuberawo enjawukana z’e byeddini wakati waabo bombi, nekitasobola kutambula bulungi, nga kino kiva mu kugaaana okukolera awamu nga abantu abali ku mulimu ogumu. Ekisinga obukulu nga kyekireeeta obutakkanya obwo kyangu okulaba. Kale obutasobola kukolera wamu olw’obukulu bwensonga eyo, nakyo kiyinza okuva ku bukyaayi okwesigamiziddwa ku kwolesebwa okulina obulemu mu bwongo, mu nfuga yaabwo egobererwa. Ekyo ne kiyimirizaawo endabika eyobulemu obutesobola era nga nayo tesoboka mu Uganda kukolebwako.
REGULATION OF RADIO FREQUENCY SPECTRUM AND ITS IMPLEMENTATION CHALLENGES IN THE PERSPECTIVE OF INTERNATIONAL LAW
Authors: Mahoro Jean Claude Geofrey , Pramono Agus
Published: August 2019

The radio frequency spectrum is a limited natural resource, which is very important and strategic in the operation of telecommunications. Considering that it is a limited natural resource, its management is regulated internationally by the International Telecommunication Union (ITU), in which details are set out in the radio regulations (RR) as an integral part of the ITU Convention. The study is based on applicable legal regulations and is supported by literature studies. The results of the study indicate that the regulation of the radio frequency spectrum is based on radio regulations, international agreements within the ITU through the World Radio communication Conference forum. The implications of regulating the use of the radio frequency spectrum always take into account the general public needs for the dynamics of the progress in telecommunications technology, of which implementation of its utilisation rests in the principle of fairness and equity between regions, and efficiency. Therefore, all policies made are directed at creating a market balance, ensuring fair competition between telecommunication operators as a potential to prevent market dominance, as well as protecting consumers.
New considerations in hematopoietic stem cell transplantation for severe combined immunodeficiency: how did newborn screening change our field, and can we finally brake the glass ceiling for haploidentical transplantation?
Authors: Marcus Nufar
Published: August 2019

Pioneered in 1968, hematopoietic stem cell transplantation (HSCT) first cured a patient with severe combined immune deficiency (SCID) transplanted from a matched sibling, bringing hope for this previously fatal disease. Since then, HSCT has become the standard of care treatment for SCID with thousands of patients transplanted successfully worldwide. Initially successful mainly in patients with a matched sibling donor and in specific easier to transplant types of SCID, nowadays, most patients with SCID undergo successful transplantation due to HSCT technique advances. These include refined human leukocyte antigen (HLA)-tissue typing, use of alternative donors, availability of new stem cell sources such as umbilical cord blood, less toxic chemotherapeutic conditioning, as well as improved graft-versus-host disease (GvHD) prophylaxis. Other factors contributing to the success of transplantation include the improvement of supportive care by molecular detection of viral infections, enabling preemptive antiviral treatment before organ damage occurs. Increased awareness for primary immunodeficiency disorders (PID), leading to earlier diagnosis and referral to specialist centers, has been another important factor in successfully transplanting SCID patients. A major game changer in the last decade has been the implementation of neonatal screening for SCID. This increased early diagnosis, allowing for this disease to be almost universally diagnosed soon after birth in countries which included this test in their newborn screening program. As a result, early and optimal transplant timing and conditions could be achieved. However, very early diagnosis also raised new questions regarding SCID patients with a “leaky” phenotype, as well as dilemmas regarding transplant and conditioning regimens in very young infants. With improved diagnosis and treatment options, overall survival has increased to over 90% for SCID babies with a genoidentical donor and similar results are emerging for matched unrelated donor HSCT. Due to new advances, we hope to achieve similar results for those given HSCT from haploidentical donors as well. This review will focus on the new considerations in HSCT seen in recent years, and examines the effect they have had on treatment options and outcomes for SCID patients.

Statement of novelty: The field of HSCT has advanced considerably since the first successful SCID bone marrow transplant in 1968. However, success rates have been limited due to delayed diagnosis and poor outcome of patients for which a HLA-matched donor could not be found. This review will discuss recent advances occurring in the last decade in HSCT for SCID, and our hopes to bring cure to this once fatal disease.
Two Classes of Nonlinear Singular Dirichlet Problems with Natural Growth: Existence and Asymptotic Behavior
Authors: Zhang Zhijun
Published: August 2019

This paper is concerned with the existence, uniqueness and asymptotic behavior of classical solutions to two classes of models-△⁢u±λ⁢|∇⁡u|2uβ=b⁢(x)⁢u-α{-\triangle u\pm\lambda\frac{|\nabla u|^{2}}{u^{\beta}}=b(x)u^{-\alpha}},u>0{u>0},x∈Ω{x\in\Omega},u|∂⁡Ω=0{u|_{\partial\Omega}=0}, where Ω is a bounded domain with smooth boundary inℝN{\mathbb{R}^{N}},λ>0{\lambda>0},β>0{\beta>0},α>-1{\alpha>-1}, andb∈Clocν⁢(Ω){b\in C^{\nu}_{\mathrm{loc}}(\Omega)}for someν∈(0,1){\nu\in(0,1)}, andbis positive in Ω but may be vanishing or singular on∂⁡Ω{\partial\Omega}. Our approach is largely based on nonlinear transformations and the construction of suitable sub- and super-solutions.
A Robust Finite Element Method for Elastic Vibration Problems
Authors: Guo Yuling , Huang Jianguo
Published: August 2019

A robust finite element method is introduced for solving elastic vibration problems in two dimensions. The temporal discretization is carried out using the

P
1

{P_{1}}

-continuous discontinuous Galerkin (CDG) method, while the spatial discretization is based on the Crouziex–Raviart (CR) element. It is shown after a technical derivation that the error of the displacement (resp. velocity) in the energy norm (resp.

L
2

{L^{2}}

norm) is bounded by

O
⁢

(

h
+
k

)

{O(h+k)}

(resp.

O
⁢

(

h
2

+
k

)

{O(h^{2}+k)}

), where h and k denote the mesh sizes of the subdivisions in space and time, respectively. Under some regularity assumptions on the exact solution, the error bound is independent of the Lamé coefficients of the elastic material under discussion. A series of numerical results are offered to illustrate numerical performance of the proposed method and some other fully discrete methods for comparison.
Voltage Control Methods in the MV Grid with a Large Share of PV
Authors: Farkas Csaba , Tóth András , Orlay Imre
Published: August 2019

The traditional distribution grid is operated radially and has passive consumers that only draw power from the grid but feed nothing back This operation is already under change so the traditional voltage regulation methods currently used in distribution systems need major modifications if we are to uphold the proper quality of electricity supply. In our paper we present the possible impact photovoltaic generation will likely have on the medium voltage grid and the means to lessen these impacts: we investigate various control options for solar inverters and a line voltage regulator as well. Simulation results indicate that the voltage profile can be maintained within the allowed limits with these regulation methods.
Zum Korpus der Leges barbarorum und seiner graphisch-phonologischen Auswertung
Authors: Stricker Stefanie
Published: August 2019

Volkssprachige Wörter in den lateinisch verfassten germanischen Stammesrechten, den sogenannten Leges barbarorum, bilden den ältesten Quellenkomplex der schriftlichen Überlieferung des Deutschen. Dieses Wortgut wird derzeit in einem Bamberger Projekt aus den Quellen erhoben und unter semantischen, morphologischen und grammatischen Aspekten analysiert. Der Beitrag will nach einer Einführung in die Quellenlage, in das Korpus und das Datenbankkonzept die Lex Baiuvariorum und die Lex Alamannorum unter graphisch-phonologischen Aspekten untersuchen und diese Ergebnisse mit den an der frühen Glossenüberlieferung des Altoberdeutschen gewonnenen vergleichen. Ziel ist es, der forschungsgeschichtlich alten Frage nach der Unterscheidbarkeit des Altalemannischen und Altbairischen erstmals unter Einbeziehung der frühen Legesüberlieferung nachzugehen.
Double Entendre in Exodus 34: Revisiting the קרן of Moses
Authors: Jarrard Eric X.
Published: August 2019

This article argues the קרן of Moses is best understood as a double entendre depicting a horned and radiant Moses. It reviews the biblical instances of קרן identifying lexicographical evidence to suggest that קרן should be interpreted as »horns« and also appeals to ancient Near Eastern iconography, in particular noting the popular »sun-god in his boat« motif of Shamash. The combined evidence suggests a double entendre used specifically for its ability to represent two prominent physical characteristics of YHWH that are imposed onto the face of Moses when he speaks face-to-face with YHWH.
Gesetz und Erzählung in Num 15: Redaktionsgeschichtliche Überlegungen zum Sabbatsünder (Num 15,32–36)
Authors: Röhrig Meike
Published: August 2019

Num 15,32–36 illustriert nicht nur das »Sündigen mit erhobener Hand« in Num 15,30, sondern ist eine sekundäre Auslegung zu Num 15,22–31 insgesamt, mit denen Vv. 32–36 ein programmatisches System sühnbarer und nicht sühnbarer Sünden und ihrer Sanktionen bietet. Num 15,32–36 nimmt zudem auf Lev 24,10–23 Bezug: Die Sabbatübertretung hat wie das Handeln des Halbägypters in Lev 24,10–23 in erster Linie illustrierende Funktion und ist nicht selbst primärer Reflexionsgegenstand. Die Wahl gerade eines Sabbatvergehens erklärt sich aus der Stellung von Num 15,32–36 im Erzählverlauf der Wüstenwanderung.
Recent advances in targeted therapy of colorectal cancer: impacts of monoclonal antibodies nanoconjugates
Authors: Akbarzadeh Khiavi Mostafa , Safary Azam , Somi Mohammad Hossein
Published: August 2019

Despite rapid advances in diagnostic and treatment approaches, the overall survival rate of cancer has not been improved. Colorectal cancer (CRC) is recognized as the third leading cause of neoplasm-related deaths worldwide, in large part due to its considerable metastasis and drug resistance. For developing new anticancer strategies, rapid progression of multimodal nanomedicines and nanoconjugates has provided promising treatment modalities for effective therapy of cancer. The limitations of cancer chemotherapy might be overcome through the use of such nanosized therapeutics, including nanoconjugates of monoclonal antibodies (mAbs) along with drugs and organic/inorganic nanoparticles. CRC cells express various molecular markers against which mAbs can be designed and used as targeting/therapeutic agents. This editorial highlights the importance of such targeted nanosystems against CRC.
Academic bullies leave no trace
Authors: Mahmoudi Morteza
Published: August 2019

Bullying in academic science is a growing concern. It may vary in severity from insults, snubs, or invasions of privacy to violations of intellectual property and unfair crediting of authors. In extreme cases it may even include coercing lab workers to sign away rights to authorship or even intellectual property. Cumbersome institutional protocols and fears of reprisal may discourage targets of bullying from reporting such incidents; lab workers in the US on visas may feel especially vulnerable. Possible strategies to combat bullying include detailed examination of relevant documentation for signs of coercion or inaccuracy and specific training on reporting for those at risk of abuse.
The effects of natural nano-sized clinoptilolite and Nigella sativa supplementation on serum bone markers in diabetic rats
Authors: Salari Lak Yalda , Khorram Sirous , Mesgari Abbasi Mehran , Asghari-Jafarabadi Mohammad , Tarighat-Esfanjani Ali , Bazri Elahe , Omidi Hossein
Published: August 2019

Introduction: Many studies confirm that diabetes mellitus is associated with higher risks of bone fracture. The beneficial effects of Nigella sativa (NS) and clinoptilolite in preventing/reducing some diabetes-related disorders have been shown. This study was conducted to examine the effects of separate and concurrent supplementation of natural nano-sized clinoptilolite (NCLN) and NS on serum bone markers in rats with type 2 diabetes. Methods: A total of 42 (case=36 and control=6) adult male Wistar rats were divided into 2 groups: diabetic and non-diabetic. An oral glucose tolerance test and a homeostatic model assessment of insulin resistance (HOMA-IR) test were conducted to confirm diabetes. Then, the diabetic group was divided into 4 subgroups: [1] control (n=9), [2] NS 1%/food (n=9), [3] NCLN 2%/food (n=9), [4] NS 1%/food + NCLN 2%/food (n=9). After 7 weeks, serum levels of bone markers were determined using ELISA kits. Results: Analysis showed that serum levels of alkaline phosphatase (ALP) in the NCLN group (1318.6 ± 217.5 U/L) was significantly (P<0.05) higher than other intervented groups. On the other hand, serum levels of calcium in NCLN+NS group (10.8 ± 2.6 mg/dL) were higher (P=0.027) compared to all other study groups. However, rats in the NS group had higher (535.8 ± 49.3 pg/mL) PTH (P<0.0001) compared to other supplementation groups. There were no significant differences in vitamin D and osteoprotegerin. Conclusion: The results of the current study suggest that bone mineralization may be affected by concurrent use of NS and NCLN through influencing calcium circulation. Moreover, dietary NS administration is strongly related to an augmented level of PTH.
Electrosprayed polymeric nanobeads and nanofibers of modafinil: preparation, characterization, and drug release studies
Authors: Adibkia Khosro , Selselehjonban Sevil , Emami Shahram , Osouli-Bostanabad Karim , Barzegar-Jalali Mohammad
Published: August 2019

Introduction: Modafinil (MDF) is used orally for the treatment of attention-deficit/hyperactivity disorder and narcolepsy. It holds low solubility and high permeability; therefore, improving its dissolution properties by preparing nanoformulations can be a promising approach to enhance its oral absorption. Our aims were to prepare and characterize MDF-Eudragit® RS100 (MDF-ERS) nanoparticles by electrospray technique. Methods: Electrosprayed nanoparticles were fabricated by varying MDF to ERS ratios and concentrations. The formulations were characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), and Fourier-transform infrared spectroscopy (FTIR). Release studies were performed on nanoparticles, physical mixtures, and raw MDF. The release data were fitted to different models to understand the mechanism of the drug release. Results: Electrospraying of MDF and ERS solution resulted in the preparation of nonobeads or nanofibers, and the particulate characteristics of the obtained products were largely controlled by the polymer amount in the solution. PXRD and thermal analyses showed that MDF was an amorphous phase in the structures of nanoparticles. Using FTIR, no interaction was observed between MDF and ERS in nanoparticles. Nanoparticles showed biphasic release profiles and the order of dissolution rates was: nanofibers>MDF>nanobeads. The well-fitted model was Weibull model, indicating a Fickian diffusion as the main mechanism of release. Conclusion: The results suggest that by optimization of variables such as solution concentration of MDF-ERS nanofibers and nanobeads with higher dissolution rates can be made by electrospray. Electrospray deposition as a simple, continuous, and surfactant free method is an excellent choice for preparation of drug loaded polymeric nanoparticles.
Correlation of serum soluble Klotho with fibroblast growth factor 23 levels in chronic kidney disease patients; a single centre study
Authors: Anand Yuvaraj , Madhusudan Vijayan , Rajeevalochana Parthasarathy , Milly Mathew , Deepu George , Georgi Abraham
Published: August 2019

Introduction: Klotho is a single-pass transmembrane protein with a long extracellular domain and short cytoplasmic tail that appears to modulate aging. Objectives: This cross-sectional investigation was conducted at a tertiary care centre to find the possible correlation of serum Klotho with various biochemical parameters in Indian chronic kidney disease (CKD) patients. Patients and Methods: The study was conducted in 80 CKD patients (58 males, 22 females). Mean age was 54.21 ± 14.08 years (25-90 years). Participants included 55 CKD- hemodialysis (HD), 10 CKD- peritoneal dialysis (PD) and 15 CKD-non-dialysis (ND) patients. Results: Serum Klotho (sKlotho) in CKD-HD patients ranged from 0 to 374.36 ng/mL with a mean of 13.76±4.3 ng/mL (median: 0.0174 ng/mL). In PD patients, sKlotho ranged from 0 to 374.36 ng/ mL with a mean of 37.58 ± 6.56 ng/mL (median of 0.0087 ng/mL). In ND population, sKlotho ranged from 0 to 7.01 ng/mL, with a mean of 0.73 ± 0.01 ng/mL (median of 0.1687ng/mL). In CKDHD and CKD-PD patients, sKlotho was positively correlated with the fibroblast growth factor 23 (pg/mL) (P<0.001). Conclusion: Serum Klotho levels show significant positive correlation with FGF23 levels in HD and PD patients. The findings of the study indicate that high Klotho and fibroblast growth factor 23 levels may be associated with worse outcomes in chronic renal failure patients.
Practitioner Perceptions of Evidence-Based Practice in Elite Sport in the United States of America
Authors: Fullagar Hugh H.K. , Harper Liam D. , Govus Andrew , McCunn Robert , Eisenmann Joey , McCall Alan
Published: August 2019

Fullagar, HHK, Harper, LD, Govus, A, McCunn, R, Eisenmann, J, and McCall, A. Practitioner perceptions of evidence-based practice in elite sport in the United States of America.J Strength Cond Res33(11): 2897–2904, 2019—Practitioners' perceptions regarding the use and effectiveness of research evidence in sport is not well understood. The purpose of the present study was to examine practitioners' perceptions around the use, implementation, and barriers to evidence-based practice (EBP) in sport science in the United States of America (USA). A survey (28 items) was completed by 67 full-time staff who were a physical performance team member employed by universities or professional sporting organizations in the USA. Questions included the use of research, contribution of research areas, barriers to accessing and implementing EBP, and methods of feedback to the coach and players. All respondents (100%) stated they used research evidence in their performance/training program, ranking research as contributing most (largest contribution = 1 to smallest contribution = 4) to individualized preparation or recovery recommendations (1.98 ± 1.02). The top 3 preferred sources of information were “peer-reviewed research” (100% of respondents), “conferences/seminars” (76%), and “practitioners within your sport” (63%). Commonly reported perceived barriers between accessing and implementing research were “lack of staff” (accessing = 33%, implementing = 46%) “time” (accessing = 38%, implementing = 48%) and nonapplicable research (accessing = 33%, implementing = 37%), whereas “poor player compliance” was a clear barrier to implementing EBP (56%). Practitioners most preferred, and actual, method of feedback for coaching staff (87% for both) and players (94 and 95%, respectively) was “informal conversations/speaking.” Improved access to educational and financial resources, increased integration of staff in coach settings and understanding of player/coach contexts may help to alleviate barriers to EBP.
Testing Competing Hypotheses on the Interplay of Importance and Support of the Basic Psychological Needs at Work and Personality Development with Response Surface Analysis
Authors: Deventer Jennifer , Humberg Sarah , Lüdtke Oliver , Nagy Gabriel , Retelsdorf Jan , Wagner Jenny
Published: August 2019

Even though environmental contexts have been associated with personality development, little attention has been paid to individuals’ psychological perceptions thereof. Basic psychological needs theory assesses environments based on their levels of autonomy, competence, and relatedness support. In order to better understand the factors that drive personality development we related the support of basic psychological needs (BPN) and the individual importance ascribed to BPN support to Big Five personality development 1.5 years later. We focused on the context of the first job in a longitudinal study of young Germans (NT1 = 1,886; MageT1 = 18.41). Based on theory and previous research we derived multiple hypotheses and tested them simultaneously against each other with an information theoretic approach including response surface analyses. Results differed across the Big Five: Controlling for personality at T1, people who ascribed greater importance to BPN support, had higher perceptions of BPN support, and who had an incongruence between the two at T1 were higher in emotional stability and extraversion at T2. The pattern was more complex for openness, whereas individuals ascribing more importance to BPN support at T1 were more agreeable and conscientious at T2. Findings are discussed for theory and future research of personality development.
The Ecological Politics Surrounding the Downsizing and Downgrading of Public Park: A Reflection on the History of Change of the Harare Gardens in Zimbabwe
Authors: Matamanda Abraham R. , Chirisa Innocent , Mangara Fortune , Dzvimbo Munyaradzi A.
Published: August 2019

The study of protected area downgrading and downsizing (PADD) in Africa has largely been confined to rustic and nature reserves outside urban boundaries. This study addresses the gap in research practice and puts a focus on urban public parks, a reference to Harare Gardens, located within central Harare. The case study of this important park engaged the political ecology lenses as a basis for understanding the significance of public parks in urban environments. Operationalization of the study involved interviews with various stakeholders including the city officials and experts in urban planning and conservation, as well as observations and examination of published documents. Several lessons and observations are made. First, downsizing is mainly a result of increasing demand for urban land in Harare, which seems to be exhausted. Second, downscaling was explained through eco-development where the City of Harare sought to maximize on land-use. Third, the rationale for the PADD of Harare Gardens has been mainly for selfish reasons by individuals who manipulate the land market in Harare and subsequently benefit from the process. Fourth, politics takes a central role in influencing the occurrence of PADD in Zimbabwe that has been the case with Harare Gardens. Our findings suggest that the decision to downsize Harare Gardens was largely politically driven considering that such occurrences have been on-going in the city and led to the downsizing and downgrading of other protected areas such as wetlands.
Silent Witnesses:
Authors: Hartman Joseph R.
Published: August 2019

In Silent Witnesses: Modernity, Colonialism, and Jean-Claude Nicolas Forestier's Unfinished Plans for Havana, Joseph R. Hartman examines Havana's urbanization under the dictatorship of Gerardo Machado (in power 1925–33), focusing on the largely unrealized plans of French urbanist Forestier and his Franco-Cuban team of architects and planners. Scholars until now have focused on cataloguing the regime's extant monuments, while giving far less attention to Forestier's unbuilt urban works. The Machado regime's building campaign spoke to modern aspirations of Cuban independence and nationhood, but also to enduring colonial paradigms of race, power, and urban space. Interpreting the history of Havana's urbanization requires taking a critical view of Cuba's colonial heritage and the survival into modern times of local and imported colonialist practices. Revisiting this history lends new insights into the cultural stakes of urban restoration efforts ongoing in Havana today.
A Comparative Study of TAVR versus SAVR in Moderate and High-Risk Surgical Patients: Hospital Outcome and Midterm Results
Authors: Abdelgawad Ahmed Moustafa Ewiss , Hussein Mohamed A. , Naeim Hesham , Abuelatta Reda , Alghamdy Saleh
Published: August 2019

Background: Although the use of transcatheter aortic valve replacement (TAVR) has recently become an attractive strategy in prohibitive surgical high-risk patients undergoing aortic valve replacement (AVR), the most appropriate treatment option in patients with an intermediate- to high-risk profile— whether conventional surgery (SAVR) or TAVR—has been widely debated.
Methods: One hundred and forty-three consecutive patients with intermediate to high risk were prospectively enrolled and selected to undergo SAVR (Group 1 [G1], n = 63) or TAVR (Group 2 [G2], n = 80) following a multidisciplinary evaluation including frailty, anatomy, and degree of atherosclerotic disease of the aorta/peripheral vessels. The mean logistic EuroSCORE (G1 = 20.11 ± 7.144 versus G2 = 23.33 ± 8.97; P = .022), STS score (G1 = 5.722 ± 1.309 versus G2 = 5.958 ± 1.689; P = .347), and preoperative demographics such as sex, left ventricular ejection fraction (LVEF),  body mass index (BMI), peripheral vascular disease, diabetes, atrial fibrillation, renal impairment and syncope were similar. Of note, chronic obstructive pulmonary disease was more frequent in TAVR patients (G2 [46.2%] versus G1 [19.0%]; P = .001), whereas pulmonary hypertension was more frequent in SAVR group (G1 [47.6%] versus G2 [17.5%]; P = .000). The SAVR was performed with either a mechanical or tissue valve; meanwhile, TAVR was performed with either Core valve prosthesis or Edwards-Sapiens XT valve.
Results: SAVR group showed higher incidence of some postoperative complications compared to TAVR, namely, postoperative bleeding (4.8% versus 0.0%; P = .048), tamponade (4.8% versus 0.0%; P = .048) and postoperative atrial fibrillation (34.9% versus 10.0%; P = .000), whereas TAVR group had a higher incidence of other sets of postoperative complications, namely, left bundle branch block (58.8% versus 4.8%; P = .000), need for permanent pacemaker implantation (25.0% versus 1.6%; P = .000) and peripheral vascular complications (15.0% versus 0.0%; P = .001). On the contrary, when the two groups were compared they did not show any significant difference regarding anemia requiring more than two units of blood transfusion, postoperative renal failure, stroke, myocardial infarction, and hospital mortality. P = .534, .873, .258, .373 and .072 respectively. Hospital mortality was similar among the two groups (G1 = 0% versus G2 = 5%; P = .072). At the 24-month follow-up, overall mortality, major adverse cardiac and cerebrovascular events were comparable between the two groups but prosthetic regurgitation was better in SAVR group (G2 = 8 patients [10.0%] versus G1 = 1 patient [1.6%] in SAVR group; P = .040).
Conclusion: In this study, we could not detect an advantage in survival when SAVR or TAVR were utilized in intermediate to high surgical risk patients needing aortic valve replacement for severe aortic stenosis.
Delayed Sternal Closure in Congenital Heart Surgery: A Risk-Benefit Analysis
Authors: Elassal Ahmed Abdelrahman , Eldib Osama Saber , Dohain Ahmed Mohamed , Abdelmohsen Gaser Abdelmohsen , Abdalla Ahmed Hassan , Al-Radi Osman Osama
Published: August 2019

Background: Delayed sternal closure commonly is used after pediatric cardiac surgery. Its benefits include relieving cardiac compression and stabilizing postoperative critically ill patients.
Methods: We retrospectively reviewed the records of 72 patients, who had undergone delayed sternal closure, among 1,254 patients operated for congenital heart diseases. Indications of delayed sternal closure, perioperative hemodynamic and metabolic status, postoperative infection, and mortality were reported.
Results: Transposition of great arteries was the most common preoperative cardiac pathology (26.3%). Bleeding and hemodynamic instability were the most frequent indications for delayed sternal closure, representing 38.8% and 34.7%, respectively. The mean duration of open chest was 3.45 days ± 1.46 days. The mean duration of ICU stay was 20.95 days ± 20.06 days. Two patients had deep sternal wound infection. Sepsis was found in 39 patients (54.1%), and the most common causative organism was coagulase negative (30.5%). ICU stay was a significant risk factor for sepsis (P = .003); duration of open sternum, period of mechanical ventilation (MV), and total hospital stay were not statistically significant risk factors. Sternal closure time (SCT) was affected by period of hemodynamic instability (P = .036). Bypass time, clamping time, and nonsurgical bleeding did not significantly affect SCT. The mortality rate was 15.2% (N = 11).
Conclusion: Delayed sternal closure is a simple and effective technique that could prevent postoperative cardiac compression in hemodynamic instability states after pediatric cardiac operations.
A Postmodern Reproduction of Dante Alighieri’s Exile
Authors: Sanna Antonio
Published: August 2019

THE NOSTALGIA OF HANNIBAL LECTER: A POSTMODERN REPRODUCTION OF DANTE ALIGHIERI’S EXILE AbstractIn this paper I shall argue that, in Ridley Scott's film Hannibal, Dr. Lecter's hiding could be interpreted as a self-enforced exile which epitomises postmodern nostalgia in his attempt to re-create the medieval past into the present. By specifically analysing the "conference" scene of Scott's film, I shall demonstrate that Dr. Lecter's study of the figures of Judas and Pier della Vigna as well as of Dante's Inferno melancholically reflects upon his own exile from America. Specifically, I shall argue that Dr. Lecter's presence in the town of Florence is a reproduction and simultaneously an inversion of Dante's exile. Indeed, by referring to the recent critical works on the practice and experience of exile in the Middle Ages (in particular, during the Italian Renaissance), I shall establish a parallel between the medieval manifestations of exile and...