bluuebunny/crossref_metadata_2025 huggingface dataset:
Outcome of COVID-19 in patients with idiopathic inflammatory myopathy during the Omicron wave in China: A longitudinal observational study
Authors: Li Ying , Tian Xiaolan , Sun Chao , Wei Yangyang , Jiang Wei , He Linrong , Li Chunjia , Zhang Lu , Wang Guochun , Lu Xin
Published: February 2025

Objective

The coronavirus disease pandemic brought unknown challenges to patients with idiopathic inflammatory myopathy, who are often heavily immunosuppressed and have comorbidities. We aimed to investigate the outcomes and risk factors of coronavirus disease in Chinese patients with idiopathic inflammatory myopathy during the Omicron wave.

Methods

This observational study included patients with idiopathic inflammatory myopathy who visited the China-Japan Friendship Hospital. Data on baseline characteristics and coronavirus disease-related information were collected through medical records and surveys, and subsequently analysed.

Results

Overall, 204 patients with idiopathic inflammatory myopathy were identified; dermatomyositis was the most common idiopathic inflammatory myopathy subtype. Data were collected from 185 patients with idiopathic inflammatory myopathy who tested positive for severe acute respiratory syndrome coronavirus 2 via polymerase chain reaction or antigen tests; of these, 20 experienced a severe course of the disease, and 9 died. All patients with severe coronavirus disease had idiopathic inflammatory myopathy-associated interstitial lung disease, and the most common antibodies observed in patients with mortality were anti-aminoacyl tRNA synthetase and anti-MDA-5 antibodies. Furthermore, 45.0% of patients in the severe disease group took > 15.0 mg of prednisone daily before infection, a significantly higher proportion than that in the non-severe disease group. Advanced age, mechanics’ hands, dyspnoea, chronic cough and fever during the course of myositis, low lymphocyte count, low serum albumin level, and high D-dimer and ferritin levels before infection were prominent in patients with severe coronavirus disease. Albumin levels below 35.0 g/L and ferritin levels above 306.8 ng/mL were independent risk factors of severe coronavirus disease.

Conclusion

Omicron did not worsen the overall outcomes of coronavirus disease for patients with idiopathic inflammatory myopathy; however, specific risk factors were identified, highlighting the need for targeted management strategies.
Addressing imbalanced data classification with Cluster-Based Reduced Noise SMOTE
Authors: Hemmatian Javad , Hajizadeh Rassoul , Nazari Fakhroddin
Published: February 2025

In recent years, the challenge of imbalanced data has become increasingly prominent in machine learning, affecting the performance of classification algorithms. This study proposes a novel data-level oversampling method called Cluster-Based Reduced Noise SMOTE (CRN-SMOTE) to address this issue. CRN-SMOTE combines SMOTE for oversampling minority classes with a novel cluster-based noise reduction technique. In this cluster-based noise reduction approach, it is crucial that samples from each category form one or two clusters, a feature that conventional noise reduction methods do not achieve. The proposed method is evaluated on four imbalanced datasets (ILPD, QSAR, Blood, and Maternal Health Risk) using five metrics: Cohen’s kappa, Matthew’s correlation coefficient (MCC), F1-score, precision, and recall. Results demonstrate that CRN-SMOTE consistently outperformed the state-of-the-art Reduced Noise SMOTE (RN-SMOTE), SMOTE-Tomek Link, and SMOTE-ENN methods across all datasets, with particularly notable improvements observed in the QSAR and Maternal Health Risk datasets, indicating its effectiveness in enhancing imbalanced classification performance. Overall, the experimental findings indicate that CRN-SMOTE outperformed RN-SMOTE in 100% of the cases, achieving average improvements of 6.6% in Kappa, 4.01% in MCC, 1.87% in F1-score, 1.7% in precision, and 2.05% in recall, with setting SMOTE’s neighbors’ number to 5.
User experience with pregnancy tracker mobile apps: Findings from comment-based qualitative study
Authors: Hossain Md. Alamgir , Perkins Janet , Hasan Md Tanvir , Lian Sharon Low Bee , Chowdhury Ribica , Alam Md. Tanzirul , Ahmed Anisuddin , Shomik Mohammad Sohel , El Arifeen Shams , Rahman Ahmed Ehsanur , Hossain Aniqa Tasnim , Rahman M. Shafiqur
Published: February 2025

Background

Worldwide, millions of pregnant women use pregnancy-related apps to monitor their baby’s growth and development. While most of the apps are user-friendly, not all of them are equally appealing. This study aimed to explore the user experience (UX) of pregnancy tracker mobile apps used by pregnant women.

Methods

This study explored the dynamics between users’ experiences and multifaceted dimensions of advanced features, high-quality materials and information, strict privacy policies, problem-solving abilities, and the usefulness of app features and contents. This study applied reviewers’ comment-based qualitative study, accessing crowdsourced data gathered from different pregnancy tracker app websites. A thematic and content analysis approach was used.

Results

This study found that when users are satisfied with using advanced content and features, it aligns with their perceived self-righteousness and rationality, and reflects their cultural values and expectations of using the apps. Conversely, when users encounter challenges such as erroneous baby size comparison and app updating issues, they perceive these as disadvantages of the apps utilised. Moreover, the study sheds light on the specific desires of pregnant women, highlighting their expectations for content that addresses their physical and mental well-being, as well as their unborn babies. The desire for free access reflects the cultural emphasis on cost-effectiveness, while the willingness to invest financially in enhanced experiences demonstrates the recognition of the value and potential benefits of improved content and features. This study also provides valuable insights into the complex relationship between users’ experiences, cultural values, advanced features, high-quality materials and information, privacy policies, problem-solving abilities, and relevant content in creating positive app experiences that align with users’ cultural expectations and needs.

Conclusion

This study provides essential insights into the user experience and underscores the importance of a user-centric design approach for developers. By capturing the current landscape of these digital tools, can provide valuable feedback for the enhancement of existing applications and guide the development of future iterations, ensuring the diverse preferences and expectations of pregnant women worldwide.
Identifying priorities and developing collaborative action plans to improve accessible housing practice, policy, and research in Canada
Authors: Hitzig Sander L. , Yuzwa Kirstin E. , Weichel Linda , Cohen Eva , Anderson Luke , Athanasopoulos Peter , Best Krista L. , Chow Marco , Kaiser Anita , Tomasella Franca , Guilcher Sara J. T. , Noonan Vanessa K. , Joy Richard , Abdullah Anika , Bacchus-Misir Farah , Chan Amy , Courage Marnie , Erdelyi Nikoletta , Fletcher Deborah , Galeazzi-Stirling Siobhan , Gladstone Gary , Green Jenn , Hardy Monte , Harris Evelyn , Kerr Jeffrey , Lytle Judi , MacGinnis Kyla , Malkowski Gary , Rosenbaum David , Sawchuk Julie , Terashima Mikiko , Yin Yu-Ling , VanDeVelde-Coke Sue , Sheppard Christine L.
Published: February 2025

This article describes the development of priorities and actions to improve the state of research, policy, and practice related to accessible housing in Canada for persons with disability or with accessible housing needs. A modified Delphi approach with an expert cross-sectoral panel was used to gain convergence on a set of priorities for advancing the accessible housing field in Canada. This included circulating an anonymous pre-meeting survey (N = 49) followed by an in-person planning meeting (N = 45). The expert panel at the in-person meeting identified three clusters of priorities from an initial list of 21 priorities, which included: 1) engaging with all levels of government to support accessible housing efforts; 2) developing educational resources to raise awareness about accessible housing, and creating services to facilitate locating and acquiring accessible housing; and 3) fostering meaningful engagement across key interest groups and sectors to find solutions to enact positive change in this space. The findings provide an initial roadmap for bringing greater cohesion to the accessible housing field, which will enable cross-sectoral partnerships and collective action towards informing the next generation of accessible housing standards, regulations and practices for people with accessible housing needs.
Quantifying the impacts of volume-based procurement policy on spatial accessibility of antidepressants via generic substitution: A four-city cohort study using drug sales data
Authors: Xue Aoming , Xue Qingyuan , Fu Jiahong , Fan Keye , Zhang Jiale , Cai Peiyan , Kuang Yuanyuan , Chen Yingsong , Zhou Jifang , Jiang Bin
Published: February 2025

Objective

To assess the spatial accessibility and inequality of antidepressants and its correlation with VBP (Volume-based procurement) policy using procurement data from four representative Chinese cities between 2018 and 2020.

Methods

The least-cost-path algorithm was employed to calculate travel time from each population point to the nearest medical institution. Gini coefficient and Theil index were utilized to measure accessibility and inequality. OLS (Ordinary Least Squares) and mediation analysis were used to investigate potential statistical relationships.

Results

Under the influence of the VBP policy, we observed varying degrees of growth in the procurement volumes of two antidepressants across different cities (Escitalopram: Beijing 30.3%, Shanghai 26.2%, Ningbo 37.4%, Harbin 25.7%; Paroxetine: Beijing 28.2%, Shanghai 1.2%, Ningbo 50.2%, Harbin 590.5%). The increase in the procurement volumes of antidepressants across cities was primarily driven by generic drugs (Escitalopram: Beijing 159.8%, Shanghai 75.0%, Ningbo 146.4%, Harbin 146.3%; Paroxetine: Beijing 67.3%, Shanghai 4.9%, Ningbo 58.0%, Harbin 15,758.3%). In the results on spatial inequality, we observed annual improvements across all cities, with more pronounced progress in economically underdeveloped regions (Escitalopram: Gini in Harbin decreased by 10.6%; Paroxetine: Gini in Harbin decreased by 32.6%). In Beijing, the substitution of generic escitalopram was found to be a partial mediating factor in the improvement of spatial inequality (ACME = -0.00, p-value = 0.01; ADE = -0.00, p-value = 0.02). In Harbin, the substitution of generic paroxetine was identified as a complete mediating factor for spatial inequality (ACME = -0.04, p-value = 0.01; ADE = 0.01, p-value = 0.14).

Conclusions

This study found that the spatial accessibility and inequality of antidepressant medications gradually improved under the influence of the VBP policy. These improvements can be partially attributed to the substitution of generic drugs.
The systematic techno-stylistic and chemical study of glass beads from post-15th century West African sites
Authors: Truffa Giachet Miriam , Gratuze Bernard , Genequand Denis , Loukou Yao Serge Bonaventure , Huysecom Éric , Mayor Anne
Published: February 2025

The systematic chemical analysis of large collections of archaeological glass beads is essential to better understand trade patterns at different times around the world. Glass beads’ trade towards and within sub-Saharan West Africa grew exponentially over time to culminate with the establishment of the Atlantic Trade. Although these artefacts are very commonly found in archaeological contexts dating after the 15th century CE, the assemblages are generally poorly studied from a chemical point of view. We present here the study of 916 glass beads found in five archaeological sites in Ghana, Mali, and Senegal, in contexts dated between the 15th and the mid-20th century CE. Besides the techno-stylistic classification of the whole assemblage, the compositional study of a sub-group of 578 monochrome and polychrome glass beads was performed. The 798 glass samples composing the selected beads were therefore classified based on their main chemical composition. Moreover, major, minor, and trace elements analysis by Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry (LA-ICP-MS) and the statistical analysis of the results by Principal Component Analysis (PCA) led to the identification of the probable origin of the glass. Different suppliers were distinguished for the Ghanaian earlier beads and the Senegalese and Malian later ones, in relation to the different European trade partners at different times.
Effects of whole-body vibration training as an adjunct to conventional rehabilitation exercise on pain, physical function and disability in knee osteoarthritis: A systematic review and meta-analysis
Authors: Peng Yan , Qi Qi , Lee Chai Li , Tay Yan Ling , Chai Siaw Chui , Ahmad Mohd Azzuan
Published: February 2025

Background

Knee osteoarthritis (KOA) is a prevalent degenerative joint condition that impairs mobility and quality of life. While whole-body vibration training (WBVT) shows promise as an adjunct to conventional KOA rehabilitation, its efficacy remains unclear due to inconsistent clinical evidence.

Objective

To elucidate the combined effects of WBVT and rehabilitation exercise on pain, physical function, and disability in KOA management through a systematic review and meta-analysis.

Methods

A comprehensive search was conducted across eight electronic databases (PubMed, Web of Science, Embase, PEDro, SPORTDiscus, Scopus, ScienceDirect, and China National Knowledge Infrastructure) up to February 2024. Inclusion criteria were (i) randomized controlled trials comparing combined WBVT and rehabilitation exercise versus rehabilitation alone in KOA (ii) reported clinical outcomes (iii) human studies, and (iv) publications in English or Chinese. Trial quality was assessed using the PEDro scale and Cochrane risk-of-bias tool. The meta-analysis employed random-effects models in Review Manager 5.3 to account for heterogeneity, supported by sensitivity analyses for robustness and subgroup analyses on WBVT frequency effects.

Results

Sixteen RCTs comprising 589 participants were included. The systematic review found that WBVT combined with conventional rehabilitation significantly reduced pain and improved physical function in KOA patients. The meta-analysis quantified these effects, showing that WBVT significantly (i) reduced knee pain (MD = −0.43, 95% CI [−0.70, −0.16], p = 0.002), with greater reductions observed from high-frequency WBVT, and (ii) increased isokinetic knee peak torque compared to rehabilitation exercise alone. No significant differences were found in balance, functional mobility, and disability outcomes. Sensitivity analysis of high-quality trials supported these results. However, the heterogeneity among studies and variations in control group interventions warrant cautious interpretation.

Conclusion

WBVT seems to be effective in reducing pain and enhancing muscle strength in KOA patients when used in conjunction with conventional rehabilitation. Future high-quality RCTs must standardize WBVT protocols, emphasize long-term follow-up, and refine dosage for clinically meaningful outcomes.

Systematic review registration: International prospective register of systematic reviews (PROSPERO CRD42024508386)
Factors influencing sepsis associated thrombocytopenia (SAT): A multicenter retrospective cohort study
Authors: Wang Lu , Chen Jieqing , Zhou Xiang ,   on behalf of China National Critical Care Quality Control Centre Group (China-NCCQC)
Published: February 2025

Introduction

Sepsis associated thrombocytopenia (SAT) is a common complication of sepsis. We designed this study to investigate factors influencing SAT.

Methods

Patients with sepsis (2984 in Peking union medical college hospital [PUMCH] database, 13165 in eICU Collaborative Research [eICU] database, 11101 in Medical Information Mart for Intensive Care IV [MIMIC-IV] database) were enrolled. Variables included basic information, comorbidities, and organ functions. Multi-variable logistic regression models and artificial neural network model were applied to determine the factors related to SAT.

Main results

Age and body mass index (BMI) were inversely correlated with the incidence of SAT (p-value 0.175 and 0.049 [PUMCH], p-value 0.000 and 0.000 [eICU], p-value 0.000 and 0.000 [MIMIC-IV]). Hematologic malignancies and other malignancies were positively correlated with the incidence of SAT (p-value 0.000 and 0.000 [PUMCH], p-value 0.000 and 0.000 [eICU], p-value 0.000 and 0.020 [MIMIC-IV]) except other malignancies was inversely correlated with the incidence of SAT in PUMCH database. Norepinephrine (NE) equivalents, total bilirubin (TBIL) and creatinine were positively correlated with the incidence of SAT (p-value 0.000, 0.000 and 0.011 [PUMCH], p-value 0.028, 0.000 and 0.013 [eICU], p-value 0.028, 0.000 and 0.027 [MIMIC-IV]). PaO2 / FiO2 was inversely correlated with the incidence of SAT in PUMCH database (p-value 0.021 [PUMCH]), while it was positively correlated with the incidence of SAT (p-value 0.000 [MIMIC-IV]). PaO2 / FiO2 and SAT was not related (p-value 0.111 [eICU]). TBIL, hematologic malignancies, PaO2 / FiO2 and NE equivalents ranked in the top five significant variables in all three datasets.

Conclusions

Hematologic malignancies and other malignancies were positively correlated with the incidence of SAT. NE equivalents, TBIL and creatinine were positively correlated with the incidence of SAT. TBIL, hematologic malignancies, PaO2 / FiO2 and NE equivalents ranked in the top significant variables in factors influencing SAT.
Development and effectiveness research on PBL learning-based exhibition planning program to cultivate visual communication skill
Authors:   Center For Educational Research, Hwang Kyo-taek , Shim Ji-young
Published: February 2025

Purpose: The purpose of this study is to develop an exhibition planning program and analyze the effectiveness to foster visual communication skills that can be applied to the art education of elementary schools.
Methods: The contents of the program were constructed so that the sub-competencies of visual communication skills could be used in the exhibition planning process, and the PBL teaching model and self-determination promotion program were modified and applied to the program to help the efficient use in elementary school classes. The developed program was implemented in three classes with different ages and classroom environments to examine the possibility of expansion of the application target, and an improved program was proposed based on the results derived through analysis.
Results: As a result of using the collected qualitative data as a major analysis data and supplementing it with learner questionnaires, the application of this program confirmed the improvement of learners' visual communication skills and verified the positive role of PBL in the efficient application of the program, but the effect was insignificant in self-determination promotion activities.
Conclusion: Through the analysis of the application results of the program developed in this study, it was possible to examine the possibility of cultivating visual communication skills of exhibition planning activities and the effectiveness of PBL and self-determination promotion activities in the operation process. In addition, it was possible to additionally discover the possibility of enhancing common body capabilities and creativity and convergence capabilities, and proposed an improved program that supplemented the existing program.
Exploring the Application of the Value Analysis Instruction Model
Authors:   Center For Educational Research, Lee Jae-Ho , Kim Hang-In
Published: February 2025

Purpose: The purpose of this study is to explore the application of a value analysis instruction model based on the value analysis theory, focusing in particular on investigating and analyzing teachers' questions and the level of understanding of pre-service elementary teachers according to teaching strategies.
Methods: As part of the theoretical understanding of the value analysis instruction model in moral education based on the value analysis theory, the researcher examined the importance of this instruction model and the teacher's question according to the teaching strategy. Then, through a questionnaire targeting college of education students who are pre-service elementary teachers, the researcher analyzed and discussed the level of understanding of this model and the ability to apply the value principle test were investigated and evaluated, and the results.
Results: First, most of the pre-service teachers had difficulty in presenting questioning strategies to apply this model to specific teaching situations. Second, pre-service teachers who showed a high level of understanding in ‘the value principle test’ received high scores in actual questioning strategies. Third, pre-service teachers had difficulty in the descriptive test to apply the four value principle tests.
Conclusion: The process of the value principle test requires a teaching method of ‘thinking and applying as close to a specific and realistic situation as possible’, especially considering the possibility of incorrect teachers’ questions.
A Study on the Establishment Process of Hongik Human Educational Ideology during the Construction of a New State
Authors:   Center For Educational Research, Song Ho-jung
Published: February 2025

Purpose: This study was prepared to point out that the basic educational ideology of Korea, Hongik Human Thought, is too comprehensive and abstract, and to raise the need for a concrete and democratic new educational ideology.
Methods: It has been described in a way that proves the validity of Hongik human thought as an educational ideology by reviewing many papers written on Hongik human and the contents of classics containing Hongik human thought.
Results: After liberation, the Hongik human idea in the Dangun myth became Korea's educational ideology in an atmosphere where Dangun nationalism was prevalent. However, since its adoption, there have been criticisms that the Hongik human idea is a concept based on myths and does not fit the task of the era of 'building a country where the people are the masters'. The review revealed that the concept originated from Buddhist thought in the late Goryeo Dynasty. Therefore, it is necessary to explore the Hongik human educational ideology as a new ideology in that it is important to derive a concept that encompasses the universality of humanity, which is universal and democratic value, in the 21st century of Korea's educational ideology.
Conclusion: If it is the educational ideology of Korea in the 21st century, it will be important to derive a concept encompassing the universality of humanity of universal and democratic values. In this regard, I think it is necessary to explore the educational ideology of Hongik, which is based on Buddhist ideology in the late Goryeo Dynasty, as a new ideology.
An Analysis of the Relationship Between Performance-Based and Rating-Based Measurements of Executive Functions in Elementary Students
Authors:   Center For Educational Research, Park Daecheol , Kim Hyunwook
Published: February 2025

Purpose: This study aimed to examine the relationship between performance-based and rating-based measures of executive functions (EFs) in elementary school students and to derive implications for EF assessment.
Methods: Data were collected from 101 elementary school students in Sejong City using performance-based EF measures (Go/Nogo, Digit Span, Tower of Hanoi, Task Switching, Stroop, WCST) and rating-based EF measures, including the Social-Emotional Competence Diagnostic Tool and the Korean version of the Barkley Deficits in Executive Functioning Scale. Descriptive statistics and correlation analyses were conducted.
Results: Significant correlations were observed among the performance-based EF measures, with several correlations also identified between performance-based and specific subcomponents of the rating-based EF measures. However, correlations between performance-based measures and most subcomponents of social-emotional competence were limited. In contrast, rating-based EF measures showed strong correlations with various subcomponents of social-emotional competence.
Conclusion: Performance-based measures were primarily effective in assessing traditional EF components but showed limitations in their relationship with social-emotional competence. On the other hand, rating-based measures reflected expanded EF components, such as emotional regulation and social interactions, providing a broader perspective on EFs as exhibited in students’ daily lives and learning environments. These findings highlight the need to develop assessment tools that encompass the expanded concept of EFs, laying the foundation for more effective support of students' EFs.
Emerging Challenges: Methicillin and Vancomycin Resistance in Staphylococcus aureus from Urinary Tract Infections in Ewes of Diyala Governorate, Iraq
Authors: Bak Areean Ibrahim Hassan , Al-Ezzy Ali Ibrahim Ali , Al-Zubaidi Raad Mahmood H
Published: February 2025

Methicillin resistant s. aureus is a rare cause of urinary tract infections (UTIs). Current study aims to Isolates and identify S. aureus from urine samples of ewes with UTIs and determination of antimicrobial sensitivity pattern for methicillin-Vancomycin resistant. A total of 71 urine samples were collected. S. aureus was isolated using mannitol salt agar and confirmed by VETEK2 system and conventional PCR, using (Staur 4, 6) and (mecA) primers. S. aureus was isolated from (9.85%). All S. aureus isolated from ewes, (100%) have resistance for Penicillines, cephalosporins and methicillin resistance was detected by cefoxitin screen test and confirmed by detection of MecA gene. Resistance of s. aureus to polypeptides antibiotics was detected in 100% for vancomycin and (85.72%) for Teicoplanin. Resistance of S. aureus to macrolides and Lincosamides antibiotics was detected in (14.28%) for Azithromycin and Clindamycin respectively. S. aureus isolated from ewes have absolute sensitivity for aminoglycosides, quinolones, macrolides (Erythromycin), oxazolidinone, tetracyclines, nitrofuran antibiotic, Fusidane, Ansamycins and Sulfonamides. The study found a significant prevalence of MRSA among the isolated strains of S. aureus from ewes with UTIs. This indicates a high level of resistance to beta-lactam antibiotics, posing challenges for effective treatment. The study also identified vancomycin resistance among the MRSA isolates. Vancomycin is often considered a last-line defense against resistant bacteria, so the presence of vancomycin-resistant S. aureus is concerning and limits treatment options.
Growth Response and Carcass Yield of Male Japanese Quail Fed Diets Contained Fermented Rubber (Hevea brasiliensis) Seed Meal
Authors: Hertamawati Rosa Tri , Suryadi Ujang , Prasetyo Anang Febri , Rahmasari Reikha , Imam Shokhirul , Asrianto Noor
Published: February 2025

This paper discusses the previous research on the use of fermented rubber seed meal using tempeh yeast (Rhizopus oligosporus) (FRSM) given to male quail from 1 to 5 weeks of age on the growth performance and carcass production.  The research used a Completely Randomized Design (CRD) experimental method using about 260 male quail aged 0-5 weeks divided into 4 treatment groups with the level of giving fermented rubber seed meal (FRSM) using different fermented yeast, namely R0= feeding without FRSM (control), R1= feeding of 4% FRSM, R2 = feeding of 8% FRSM, and R3= feeding of 12% FRSM.  Each treatment was repeated 5 times, making 20 units of 13 male quails.  The parameters observed were feed consumption, body weight gain, feed conversion, and carcass production.  Rubber seed fermentation in this research showed that rubber seeds' cyanide acid (HCN) content was reduced from 158.64 ppm to 17.84 ppm.  The experimental results showed that adding fermented rubber seed meal to the diets did not decrease feed consumption or prevent weight gain, feed conversion, final body weight, carcass weight, and carcass percentage.  This research concluded that adding fermented rubber seed meal up to 12% did not harm male quail's growth performance and carcass yield.
Association of skin temperature, cumulative dose of radiation, and the diagnosis of radiodermatitis
Authors: Shiguihara Dryelle Soster Iede , Ulbricht Leandra , Neves Eduardo Borba
Published: February 2025

Radiotherapy is one of the treatments of cancer, and radiodermatitis is one of the side effects, with a negative impact on the patient's quality of life, which can lead to limitation dose of radiation, delay in completion, or discontinuation of treatment. Recent studies show evidence that thermography can be useful in this context of radiodermatitis, as it is a technology that has been improved, there are still few studies showing thermal response and mapping of radiation dermatitis. This study analyzed the association between skin temperature, cumulative radiation dose, and the appearance of radiodermatitis. The research was carried out with 76 participants with skin, head or neck cancer and thermographic recording immediately before and after irradiation. The Radiation Therapy Oncology Group scale was used to diagnose radiodermatitis. As the main results in our sample, 70% of the participants had some degree of radiodermatitis, and significant differences in skin temperature were observed when compared to participants without (32.88 °C) and with radiodermatitis (thermal difference in average temperature greater than 1.0 °C for both grade I and grade II radiodermatitis). The ideal time for thermographic evaluation would be after receiving the daily dose, where we found a moderate correlation (0.474) between the temperature of the affected side after irradiation and the pre-irradiation cumulative dose. Our results demonstrate that radiodermatitis change skin temperature and thermographic analysis can quantify. Finally, to improve early diagnosis, we recommend that scales be constructed with greater definitions for the classification of radiation toxicity, without overlapping symptoms, considering quantitative criteria.
PERUBAHAN BUDAYA DALAM TAFSIR AL-QUR’AN (TELAAH TERHADAP PENAFSIRAN MUHAMMAD ABDUH DALAM TAFSIR AL-MANAR)
Authors: Muhsin Imam
Published: February 2025

Tafsir al-Quran has the position is very important for the life of the people of Islam and its history. Because, with the interpretation of the procedures against the Qur’an, they could develop a global view of the world, history, meaning, and destiny of man. In other words, all legal norms, ethics, moral, political, and intellectual plucked from textual forms of Scripture through interpretation. The fact that the history and culture of the Muslims are not affected by the Qur’an directly, but rather determined by the interpretation of the results (or, at least, the result of the reading) of the Scriptures, to reaffirm the importance of getting the Tafsir of the Qur’an. The efforts to interpret is done by the historical communities in the cultural environment of the concrete and is constantly changing. The changes that inevitably to be followed by tafsir al-Qur’an so that the messages contained therein can be grounded according adagium: al-Qur’an wa makân zamân likulli shâlihun. In the context of this is the interpretation of Muhammad Abduh in his Tafsir al-Manar can be read as a change of culture, through the process of reintegration of value and reorient the meaning.Keywords: Integration, muslim culture and tafsir al-quran
Strongly nonlinear Robin problems for harmonic and polyharmonic functions in the half-space
Authors: Cianchi Andrea , Diebou Gael Y. , Slavíková Lenka
Published: February 2025

Existence and global regularity results for boundary-value problems of Robin type for harmonic and polyharmonic functions in n-dimensional half-spaces are offered.
The Robin condition on the normal derivative on the boundary of the half-space is prescribed by a nonlinear function

𝒩

{\mathcal{N}}

of the relevant harmonic or polyharmonic functions. General Orlicz-type growths for the function

𝒩

{\mathcal{N}}

are considered. For instance, functions

𝒩

{\mathcal{N}}

of classical power type, their perturbations by logarithmic factors, and exponential functions are allowed. New sharp boundedness properties in Orlicz spaces of some classical operators from harmonic analysis, of independent interest, are critical for our approach.
Duality theorems for polyanalytic functions
Authors: Colombo Fabrizio , De Martino Antonino , Diki Kamal , Sabadini Irene , Struppa Daniele C.
Published: February 2025

The goal of this paper is to give a characterization of the dual of the space of polyanalytic functions on the complement of a compact set K and vanishing at infinity. The class of polyanalytic functions generalizes holomorphic functions and serves as a middle ground between holomorphic functions in one complex variable and those in two complex variables. The duality result is also expressed in topological terms through a new class of infinite-order differential operators, which includes well-known families of operators like the Laplace and Helmholtz operators. Since the notion of polyanalytic function generalizes that of holomorphic function, the duality theorems established in this paper can be considered a non-trivial generalization of the Köthe–Grothendieck theorem.
On isometry groups of gradient Ricci solitons
Authors: Dung Ha Tuan , Tran Hung
Published: February 2025

We give a result estimating the dimension of the Lie algebra of Killing vector fields on an irreducible non-trivial gradient Ricci soliton. Then we study the structure of this manifold when the maximal dimension is attained. There are local and global implications.
Toeplitz operators on weighted Bergman spaces over tubular domains
Authors: Li Lvchang , Ding Jiaqing , Li Haichou
Published: February 2025

In this paper, we mainly study the necessary and sufficient conditions for the boundedness and compactness of Toeplitz operators on weighted Bergman spaces over a tubular domains by using the Carlson measures on tubular domains. We also give some related results about Carlson measures.
Toeplitz operators on Bergman spaces with variable exponents
Authors: Shen Conghui , Li Songxiao , Long Sujuan
Published: February 2025

In this paper, the boundedness and compactness of Toeplitz operators

T
ϕ

{T_{\phi}}

with the symbol

ϕ
∈

L
1

⁢

(
𝔻
)

{\phi\in L^{1}(\mathbb{D})}

between different Bergman spaces with the log-Hölder continuous variable exponents are investigated.
Blow-up of solutions to some classes of ill-posed operator equations and a growth quantification result
Authors: Abbas Jehan R. , Flores Mercy Grace C. , Reyes Noli N. , Vallejo Louie John D.
Published: February 2025

Let

ℋ

{\mathcal{H}}

and

𝒦

{\mathcal{K}}

be real Hilbert spaces, let

T
:

ℋ
→
𝒦

{T:\mathcal{H}\to\mathcal{K}}

be a continuous operator with a non-closed range, and let

y
∈

ran
⁡
T

¯

∖

ran
⁡
T

{y\in\overline{\operatorname{ran}T}\setminus\operatorname{ran}T}

. In the case where

ℋ

{\mathcal{H}}

is finite-dimensional, or T is linear, or

ℋ
=
𝒦

{\mathcal{H}=\mathcal{K}}

and

Id
-
T

{\operatorname{Id}-T}

is nonexpansive, we show that the approximate solutions to

T
⁢
x

=
y

{Tx=y}

blow up. We also show that the blow-up of approximate solutions is not necessary by constructing a continuous mapping

T
:

L
2

⁢

(

[
0
,
1
]

)

→

L
2

⁢

(

[
0
,
1
]

)

{T:L^{2}([0,1])\to L^{2}([0,1])}

, a vector

y
∈

ran
⁡
T

¯

∖

ran
⁡
T

{y\in\overline{\operatorname{ran}T}\setminus\operatorname{ran}T}

, and a bounded sequence of approximate solutions to

T
⁢
x

=
y

{Tx=y}

. Finally, if

T
:

ℋ
→
𝒦

{T:\mathcal{H}\to\mathcal{K}}

is compact and self-adjoint, and

y
∈

ran
⁡
T

¯

∖

ran
⁡
T

{y\in\overline{\operatorname{ran}T}\setminus\operatorname{ran}T}

, we obtain a growth quantification result via an inequality of the form

φ
y

⁢

(

∥

T
⁢
x

-
y

∥

)

⋅

∥
x
∥

≥
C

{\varphi_{y}(\|Tx-y\|)\cdot\|{x}\|\geq C}

where

φ
y

{\varphi_{y}}

is a nondecreasing function and C is a positive constant.
Topological descriptors and connectivity analysis of coronene fractal structures: insights from atom-bond sum-connectivity and Sombor indices
Authors: Zhang Xiujun , Aftab Sahar , Noureen Sadia , Aslam Adnan , Ibrahim Sobhy M.
Published: February 2025

Coronene, a polycyclic aromatic hydrocarbon (PAH) consisting of six benzene rings fused in a hexagonal arrangement, exhibits a fractal structure that is significant in various fields such as condensed matter physics, materials science, surface science, and interdisciplinary areas like nanotechnology and astrochemistry. Topological descriptors, which characterize the geometric and connectivity properties of a structure independently of specific spatial coordinates, are crucial for understanding coronene’s complex geometry and connectivity. In this study, we compute the atom-bond sum (ABS)-connectivity index and four versions of the Sombor indices for three different configurations of the coronene fractal structure: Zig-zag Hexagonal Coronene Fractal (ZHCF), Armchair Hexagonal Coronene Fractal (AHCF), and Rectangular Coronene Fractal (RCF). To assess their chemical applicability, we develop linear regression models to estimate the physicochemical properties boiling point (BP) and molecular weight (MW) of benzene derivatives using these topological indices. The regression parameters for each case are provided, and the results show that the ABS index outperforms all other topological indices, making it the most effective predictor for these properties.
Telephelyi tényezők Magyarországon, a gazdasági szerkezet és a településpolitika vállalati megítélése
Authors: Koltai Zoltán
Published: February 2025

A magyarországi települések versenyképességének vállalati megítélése című, rétegzett kérdőíves kutatásunk keretében ezer vállalkozó, vállalatvezető adott választ kérdéseinkre. Kérdőívünkben többek között arra kerestünk választ, hogy milyen tényezőket részesítenek előnyben a magyar vállalati szféra szereplői telephelyük megválasztásakor, mely városainkhoz kapcsolható karakterisztikus jegyként a kedvező gazdasági szerkezet, valamint a hatékony helyi településpolitika.
Kijelenthető, hogy a magyar vállalkozások költségérzékenyebbé váltak a kutatásaink által érintett bő tíz évben, a korábbiaknál is fontosabbá vált számukra a felkészült és hatékony munkaerő megléte. Ezekhez a változásokhoz párosult a helyi önkormányzatok településpolitikai aktivitásának megnövekedett jelentősége, ami a mikroszinttől a nagyvállalati szintig egyaránt megfigyelhető jelenség.
Study on the Rheological Properties and Modification Mechanism of Graphene/Rubber Composite-Modified Asphalt
Authors: Lin Mei , Lei Yu , Li Ping , Li Wang Zhao
Published: February 2025

To explore the rheological properties and the modification mechanism of graphene/rubber composite-modified asphalt, a dynamic shear rheometer and low-temperature bending rheometer were used to study the high and low-temperature rheological properties of graphene/rubber composite-modified asphalt. Second, the microstructure and chemical structure of the asphalt were characterized by using Fourier transform infrared spectroscopy and optical microscopy, and the component model of asphalt was constructed with molecular dynamics simulation technology to explore the modification mechanism of graphene/rubber composite-modified asphalt. The results show that compared with rubber-modified asphalt, graphene/rubber composite-modified asphalt effectively improves the high-temperature deformation resistance and low-temperature crack resistance of asphalt, but the ability of graphene to improve the low-temperature performance of asphalt is limited at −24°C or even lower temperatures. The addition of graphene promotes the swelling development of rubber, improves the bonding stability between rubber and resin, and enhances the compatibility between rubber and asphalt systems. Graphene can weaken the aggregation behavior of rubber and asphaltene, and the distribution of rubber and asphaltene in asphalt is more uniform, further improving the overall stability of the asphalt system. Graphene promotes the adsorption of lightweight components by rubber, leading to a decrease in the diffusion coefficients of saturated and aromatic components in asphalt systems. This is also an important reason for the improved high-temperature performance of graphene/rubber-modified asphalt.
Identification of a novel population of neuromedin S expressing neurons in the ventral tegmental area that promote morphine-elicited behavior
Authors: Rivera Quiles C. , Simmons S.C. , Dodson O. , Alday M. , Camacho Fontánez N. , Caico S. , Garrison A. , Shafieichaharberoud F. , Huang X. , Hu Q. , Heller E.A. , Mazei-Robison M.S.
Published: February 2025

Opioid use disorder constitutes a major health and economic burden, but our limited understanding of the underlying neurobiology impedes better interventions. Alteration in the activity and output of dopamine (DA) neurons in the ventral tegmental area (VTA) contributes to drug effects, but the mechanisms underlying these changes remain relatively unexplored. We used translating ribosome affinity purification and RNA sequencing to identify gene expression changes in mouse VTA DA neurons following chronic morphine exposure. We found that expression of the neuropeptide neuromedin S (Nms) is robustly increased in VTA DA neurons by morphine. Using an NMS-iCre driver line, we confirmed that a subset of VTA neurons express NMS and that chemogenetic modulation of VTA NMS neuron activity altered morphine responses in male and female mice. Specifically, VTA NMS neuronal activation promoted morphine locomotor activity while inhibition reduced morphine locomotor activity and conditioned place preference (CPP). Interestingly, these effects appear specific to morphine, as modulation of VTA NMS activity did not affect cocaine behaviors, consistent with our data that cocaine administration does not increase VTANmsexpression. Chemogenetic manipulation of VTA neurons that express glucagon-like peptide, a transcript also robustly increased in VTA DA neurons by morphine, does not alter morphine-elicited behavior, further highlighting the functional relevance of VTA NMS-expressing neurons. Together, our current data suggest that NMS-expressing neurons represent a novel subset of VTA neurons that may be functionally relevant for morphine responses and support the utility of cell type-specific analyses like TRAP to identify neuronal adaptations underlying substance use disorder.

Significance StatementThe opioid epidemic remains prevalent in the U.S., with more than 70% of overdose deaths caused by opioids. The ventral tegmental area (VTA) is responsible for regulating reward behavior. Although drugs of abuse can alter VTA dopaminergic neuron function, the underlying mechanisms have yet to be fully explored. This is partially due to the cellular heterogeneity of the VTA. Here, we identify a novel subset of VTA neurons that express the neuropeptide neuromedin S (NMS).Nmsexpression is robustly increased by morphine and alteration of VTA NMS neuronal activity is sufficient to alter morphine-elicited behaviors. Our findings are the first to implicate NMS-expressing neurons in drug behavior and thereby improve our understanding of opioid-induced adaptations in the VTA.
Define a Dragon
Authors: Fabrykant Marharyta
Published: February 2025

This article is dedicated to the ways China’s history is narrated in contemporary Russian world history textbooks. The study relies on the formal structural version of narrative analysis applied to all three series of textbooks included in the federal list of textbooks recommended for teaching world history in Russia’s secondary and high schools and aims at revealing the internal logic of China’s history narrative and its place in the overarching plot of world history narrative. The research findings show China’s history narrative presented in the Russian textbooks to considerably differ from that prevailing in the Chinese historiography and combine a relatively Eurocentric approach with projections of Russia’s own identity-related issues—technological vs. sociopolitical modernization, historical agency, and opportunities vs. risks of openness to the world. These results show how a foreign country’s history can be turned into a usable past not via shared experience or direct analogy but as an initially neutral material for addressing pivotal issues of one’s own country and ambivalent sides of its national identity.
Exploring some trademark issues in metaverse from EU law perspective
Authors:   University of Łódź, Poland, Sztobryn Karolina
Published: February 2025

This article addresses some issues of trademark protection in virtual worlds. The increasing presence of trademarks in the metaverse, as evidenced by the growing number of trademark applications for virtual goods and services, is likely to intensify legal conflicts related to trademarks and, consequently, to lead to litigation. The development of virtual reality thus brings challenges for the interpretation and application of traditional concepts and terms used in the trademark system. This article analyzes issues that require consideration in the context of trademark protection in metaverse. It discusses the issues of registering trademarks for virtual goods, assessing the similarities between real world goods and services and their virtual world counterparts, and the enforcement of the rights to trademarks, which were used without the owner’s consent in metaverse. The analysis presented in the article leads to the conclusion that further development of the metaverse will certainly force a redefinition of traditionally applied enforcement principles, including those related to jurisdiction, as well as certain concepts known and interpreted for the application of the trademark system in the real world, such as trademark use.
Analisis Kebutuhan Pengembangan Buku Ajar Mata Kuliah Kearifan Lokal Pandhalungan
Authors: Afrizal Mohamad , Citraningrum Dina Merdeka
Published: February 2025

Pandhalungan Local Wisdom is one of the courses offered by Muhammadiyah Jember University's Indonesian Language and Literature Education Study Program. Learning in this course has various challenges due to its newness, one of which is the lack of textbooks. This study aims to conduct a needs assessment of the textbooks for the course. The goals are to describe the competency criteria, student characteristics, student evaluation against the course, and subject matter suggestions for the course textbook. The results show that the characteristics of students are: 1) the average age of 20–21 years, which is classified as young adults; 2) knowledge of Pandhalungan: high category 50.11%, medium 32.33%, and low 17.56%; 3) perception of the benefits of course learning: very important 32.44%, quite important 52.22%, less important 15.34%; and 4) learning motivation: high 69.13%, medium 21.85%, low 9.02%. It is also concluded that the recommended subject matter for this textbook is eight topics: 1). Pandhalungan Culture and Identity; 2). Pandhalungan Cultural History.) Pandhalungan Art and Cultural Expression; 4) Pandhalungan Traditions and Rituals 5) Pandhalungan Cultural Diversity 6) Changes and Dynamics of Pandhalungan Culture 7) Preservation of Pandhalungan Culture; and 8) Culture and Communication of Pandhalungan Society