bluuebunny/crossref_metadata_2025 huggingface dataset:
Maintenance of neuronal TDP-43 expression requires axonal lysosome transport
Authors: Ryan Veronica H , Lawton Sydney , Reyes Joel F , Hawrot James , Frankenfield Ashley M , Seddighi Sahba , Ramos Daniel M , Faghri Faraz , Johnson Nicholas L , Zou Jizhong , Kampmann Martin , Replogle John , Yuan Hebao , Johnson Kory R , Maric Dragan , Hao Ling , Nalls Mike A , Ward Michael E
Published: January 2025

TDP-43 mislocalization and pathology occurs across a range of neurodegenerative diseases, but the pathways that modulate TDP-43 in neurons are not well understood. We generated a Halo-TDP-43 knock-in iPSC line and performed a genome-wide CRISPR interference FACS-based screen to identify modifiers of TDP-43 levels in neurons. A meta-analysis of our screen and publicly available screens identified both specific hits and pathways present across multiple screens, the latter likely responsible for generic protein level maintenance. We identified BORC, a complex required for anterograde lysosome transport, as a specific modifier of TDP-43 protein, but not mRNA, levels in neurons. BORC loss led to longer half-life of TDP-43 and other proteins, suggesting lysosome location is required for proper protein turnover. As such, lysosome location and function are crucial for maintaining TDP-43 protein levels in neurons.
Peripheral glia and neurons jointly regulate activity-induced synaptic remodeling at the Drosophila neuromuscular junction
Authors: Chang Yen-Ching , Peng Yi-Jheng , Lee Joo Yeun , Chang Karen T
Published: January 2025

In the nervous system, reliable communication depends on the ability of neurons to adaptively remodel their synaptic structure and function in response to changes in neuronal activity. While neurons are the main drivers of synaptic plasticity, glial cells are increasingly recognized for their roles as active modulators. However, the underlying molecular mechanisms remain unclear. Here, using
Drosophila
neuromuscular junction as a model system for a tripartite synapse, we show that peripheral glial cells collaborate with neurons at the NMJ to regulate activity-induced synaptic remodeling, in part through a protein called shriveled (Shv). Shv is an activator of integrin signaling previously shown to be released by neurons during intense stimulation at the fly NMJ to regulate activity-induced synaptic remodeling. We demonstrate that Shv is also present in peripheral glia, and glial Shv is both necessary and sufficient for synaptic remodeling. However, unlike neuronal Shv, glial Shv does not activate integrin signaling at the NMJ. Instead, it regulates synaptic plasticity in two ways: 1) maintaining the extracellular balance of neuronal Shv proteins to regulate integrin signaling, and 2) controlling ambient extracellular glutamate concentration to regulate postsynaptic glutamate receptor abundance. Loss of glial cells showed the same phenotype as loss of Shv in glia. Together, these results reveal that neurons and glial cells homeostatically regulate extracellular Shv protein levels to control activity-induced synaptic remodeling. Additionally, peripheral glia maintains postsynaptic glutamate receptor abundance and contribute to activity-induced synaptic remodeling by regulating ambient glutamate concentration at the fly NMJ.
Multi-dimensional social relationships shape social attention in monkeys
Authors: Liu Sainan , Huang Jiepin , Chen Suhao , Platt Michael , Yang Yan
Published: January 2025

Social relationships guide individual behavior and ultimately shape the fabric of society. Primates exhibit particularly complex, differentiated, and multidimensional social relationships, which form interwoven social networks, reflecting both individual social tendencies and specific dyadic interactions. How the patterns of behavior that underlie these social relationships emerge from moment-to-moment patterns of social information processing remains unclear. Here, we assess social relationships among a group of four monkeys, focusing on aggression, grooming, and proximity. We show that individual differences in social attention vary with individual differences in patterns of general social tendencies and patterns of individual engagement with specific partners. Oxytocin administration altered social attention and its relationship to both social tendencies and dyadic relationships, particularly grooming and aggression. Our findings link the dynamics of visual information sampling to the dynamics of primate social networks.
Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant
Authors: Tomlinson Patsy R , Knox Rachel , Perisic Olga , Su Helen C , Brierley Gemma V , Williams Roger L , Semple Robert K
Published: January 2025

PIK3R1
encodes three regulatory subunits of class IA phosphoinositide 3-kinase (PI3K), each associating with any of three catalytic subunits, namely p110α, p110β or p110δ. Constitutional
PIK3R1
mutations cause diseases with a genotype-phenotype relationship not yet fully explained: heterozygous loss-of-function mutations cause SHORT syndrome, featuring insulin resistance and short stature attributed to reduced p110α function, while heterozygous activating mutations cause immunodeficiency, attributed to p110δ activation and known as APDS2. Surprisingly, APDS2 patients do not show features of p110α hyperactivation, but do commonly have SHORT syndrome-like features, suggesting p110α hypofunction. We sought to investigate this. In dermal fibroblasts from an APDS2 patient, we found no increased PI3K signalling, with p110δ expression markedly reduced. In preadipocytes, the APDS2 variant was potently dominant negative, associating with Irs1 and Irs2 but failing to heterodimerise with p110α. This attenuation of p110α signalling by a p110δ-activating PIK3R1 variant potentially explains co-incidence of gain-of-function and loss-of-function
PIK3R1
phenotypes.
A split-GAL4 driver line resource for Drosophila neuron types
Authors: Meissner Geoffrey W , Vannan Allison , Jeter Jennifer , Close Kari , DePasquale Gina M , Dorman Zachary , Forster Kaitlyn , Beringer Jaye Anne , Gibney Theresa V , Hausenfluck Joanna H , He Yisheng , Henderson Kristin , Johnson Lauren , Johnston Rebecca M , Ihrke Gudrun , Iyer Nirmala , Lazarus Rachel , Lee Kelley , Li Hsing-Hsi , Liaw Hua-Peng , Melton Brian , Miller Scott , Motaher Reeham , Novak Alexandra , Ogundeyi Omotara , Petruncio Alyson , Price Jacquelyn , Protopapas Sophia , Tae Susana , Taylor Jennifer , Vorimo Rebecca , Yarbrough Brianna , Zeng Kevin Xiankun , Zugates Christopher T , Dionne Heather , Angstadt Claire , Ashley Kelly , Cavallaro Amanda , Dang Tam , Gonzalez Guillermo A , Hibbard Karen L , Huang Cuizhen , Kao Jui-Chun , Laverty Todd , Mercer Monti , Perez Brenda , Pitts Scarlett , Ruiz Danielle , Vallanadu Viruthika , Zheng Grace Zhiyu , Goina Cristian , Otsuna Hideo , Rokicki Konrad , Svirskas Robert R , Cheong Han SJ , Dolan Michael-John , Ehrhardt Erica , Feng Kai , El Galfi Basel , Goldammer Jens , Huston Stephen J , Hu Nan , Ito Masayoshi , McKellar Claire , Minegishi Ryo , Namiki Shigehiro , Nern Aljoscha , Schretter Catherine E , Sterne Gabriella R , Venkatasubramanian Lalanti , Wang Kaiyu , Wolff Tanya , Wu Ming , George Reed , Malkesman Oz , Aso Yoshinori , Card Gwyneth M , Dickson Barry J , Korff Wyatt , Ito Kei , Truman James W , Zlatic Marta , Rubin Gerald M ,   FlyLight Project Team
Published: January 2025

Techniques that enable precise manipulations of subsets of neurons in the fly central nervous system have greatly facilitated our understanding of the neural basis of behavior. Split-GAL4 driver lines allow specific targeting of cell types in
Drosophila melanogaster
and other species. We describe here a collection of 3060 lines targeting a range of cell types in the adult
Drosophila
central nervous system and 1373 lines characterized in third-instar larvae. These tools enable functional, transcriptomic, and proteomic studies based on precise anatomical targeting. NeuronBridge and other search tools relate light microscopy images of these split-GAL4 lines to connectomes reconstructed from electron microscopy images. The collections are the result of screening over 77,000 split hemidriver combinations. Previously published and new lines are included, all validated for driver expression and curated for optimal cell type specificity across diverse cell types. In addition to images and fly stocks for these well-characterized lines, we make available 300,000 new 3D images of other split-GAL4 lines.
Tripartite organization of brain state dynamics underlying spoken narrative comprehension
Authors: Liu Lanfang , Jiang Jiahao , Li Hehui , Ding Guosheng
Published: January 2025

Speech comprehension involves the dynamic interplay of multiple cognitive processes, from basic sound perception, to linguistic encoding, and finally to complex semantic-conceptual interpretations. How the brain handles the diverse streams of information processing remains poorly understood. Applying Hidden Markov Modeling to fMRI data obtained during spoken narrative comprehension, we reveal that the whole brain networks predominantly oscillate within a tripartite latent state space. These states are respectively characterized by high activities in the sensory-motor (State #1), bilateral temporal (State #2), and DMN (State #3) regions, with State #2 acting as a transitional hub. The three states are selectively modulated by the acoustic, word-level semantic and clause-level semantic properties of the narrative. Moreover, the alignment with the best performer in brain state expression can predict participants’ narrative comprehension scores. These results are reproducible with different brain network atlas and generalizable to two datasets consisting of young and older adults. Our study suggests that the brain underlies narrative comprehension by switching through a tripartite state space, with each state probably dedicated to a specific component of language faculty, and effective narrative comprehension relies on engaging those states in a timely manner.
Impact of Processing and Extraction Methods on the Phytochemical Composition of Garcinia Kola Stem Bark and Stone Breaker Leaves
Authors: Origbemisoye Babawande A. , Malomo Sunday A. , Ifesan Beatrice O.
Published: January 2025

This study investigates the effects of three processing methods; blanching, drying, and fermentation on the phytochemical properties of Garcinia kola stem bark and stone breaker leaves, both of which are traditionally used in medicine. The primary aim was to evaluate how these processing techniques enhance the phytochemical profiles of these plant materials and to determine the most effective extraction method for retaining their beneficial properties, particularly for cardiovascular health. The contents of saponins, flavonoids, oxalates, phytates, tannins, and phenolic compounds in aqueous and ethanolic extracts were quantified. The results demonstrated that the fermented samples exhibited the highest flavonoid content (3.90 mg/g in fermented stone breaker ethanolic extract (FSBE) and 4.17% in fermented stone breaker aqueous extract (FSBA)) and phenolic content (75.29 mg/g in FSBA and 75.92 mg/g in FSBE). Furthermore, fermentation yielded the lowest oxalate (1.35 mg/g in fermented Garcinia kola stem bark aqueous extract (FGBA) and 1.84 mg/g in fermented Garcinia kola stem bark ethanolic extract (FGBE)) and phytate levels (20.92 mg/g in FSBA and 22.75 mg/g in FSBE). In contrast, the dried samples contained the highest saponin levels ranging from 0.09% in blanched stone breaker ethanolic extract (BSBE) to 1.34% in blanched Garcinia kola stem bark aqueous extract (BGBA). Tannin content was consistently low across all samples, ranging from 0.01 to 0.05 mg/g. While aqueous extracts displayed higher values for some components, ethanolic extracts outperformed in others. The findings underscore the health benefits of these plant materials, particularly highlighting the superiority of fermented samples due to their enriched flavonoid and phenolic content, which may significantly contribute to overall well-being, especially for cardiovascular patients.
Graduate Education and Its Influence on Employability and Career Progression: A Tracer Study of La Salle University Graduates
Authors: Maghamil Catalina W.
Published: January 2025

This descriptive research explores the impact of graduate education on the employability and career advancement of graduates. It further aims to glean insights on how the results of the tracer study can improve graduate curriculum and practices. The study involved 127 respondents who graduated from Doctor in Business Administration (DBA), Master in Business Administration (MBA), and Master in Public Administration (MPA) in the School of Graduate Studies, La Salle University Ozamiz from AY 2018-2019 to AY 2021-2022. Of this number, 42 (33%) were males and 85 (67%) were females; majority (54%) took up MBA while 27% graduated in 2021. Further, 86% were permanent employees while 68% worked in local public institutions. A tracer survey form was forwarded to the students through email and social media accounts. After the results were collated, descriptive statistics were used to analyze the results. The findings reveal that 60% of the respondents received promotions, and 65% reported salary increases after completing their graduate programs. Additionally, 85% cited professional development as the primary reason for enrolling, with them reporting enhanced work performance and career growth after graduation. The study also highlights that graduates felt highly satisfied (4.51) with the curriculum, especially its emphasis on values formation (4.73) and the integration of ethical principles (4.69), which they believed positively influenced their professional behavior. Hence, graduate education is a valuable investment, boosting job security, earnings, and career satisfaction. It helps students develop important skills like teamwork, problem-solving, and ethical decision-making, making them more competitive. The study suggests graduate programs focus on professional and ethical growth while adding hands-on experiences and industry projects to better prepare students for workforce demands.
Short-Term Evaluation of Newborns from Mothers with Grave's Disease: A Case Series Study
Authors: Boiro Djibril , Seck Ndiogou , Sow Amadou , Ndongo Aliou A. , Mbaye Aminata , Ndiaye Mame Bineta , Sow Ndeye Fatou , Gadji Fatou Kiné , Thioye Elhadji Mamadou , Guéye Modou
Published: January 2025

Introduction: Maternal Graves' disease may be responsible for neonatal complications as well as neonatal hyperthyroidism. The aim was to determine the characteristics and course of neonates born to mothers with Graves' disease.
Materials and Methods: This was a descriptive retrospective case series study conducted jointly by the Internal Medicine and Pediatrics departments of the Abass Ndao Hospital in Dakar. It involved patient records registered from 2006 to 2021.
Results: One hundred and thirty-seven (137) mothers with their newborns were included. The mean age was 29 years with +/- 6.93. The diagnosis of Graves' disease was known prior to pregnancy in 119 of our patients (86.8%). The majority of mothers (59.22%) were on imidazole alone prior to pregnancy.
Birth weights ranged from 1,200 g to 7,000 g, with an average of 2,775.6 g. Most newborns were eutrophic (61.32%). Forty-seven newborns (34.3%) presented complications, including 16 cases of neonatal death. Two-thirds (22/33) of infants were euthyroid. 56.20% of mothers practiced exclusive breast-feeding, mostly with therapeutic abstention or readjustment of synthetic antithyroid drugs doses. Only 33 (24%) newborns had a thyroid check-up. During the first three months of life, there were 9 cases (27.7%) of hyperthyroidism and 2 cases of hypothyroidism. At 6 months, 3 cases of persistent hyperthyroidism. One had associated bilateral exophthalmos.
Conclusion: Thyroid disorders affect one-third of children born to basedowian mothers. However, they are transient in the majority of cases. It is also worth noting the low rate of systematic thyroid work-up, which may bias the interpretation of the results obtained.
Ecological Engineering Using Biological Crusts: Effects on Soil Physicochemical Properties in West-Central Region of Burkina Faso
Authors: MARE Boussa Tockville Josue , WAGNER Ines , LANKOANDE Yiénibirma Josias , LANKOANDE Benjamin , SPYCHALSKI Waldemar , WOLKO Lukasz , JUILLERET Jérôme
Published: January 2025

The land degradation in Burkina Faso is one of the major development challenges in the agricultural sector. Among the various existing means of soil recovery and improvement, the use of ecological engineering based on soils microorganisms also appears as a tool for sustainable land management. For this purpose, a trial was set up in Péyiri in the West-Center region of Burkina Faso and focused on studying the effects of induced biological crusts on the physicochemical properties of degraded soils. A split-plot design with three replications was set up on three types of soil environment with increasing degradation level, namely "Soil environment with a dense herbaceous layer and some shrubs" (Site 3), "Soil environment with a less dense herbaceous layer" (Site 2) and "Bare soil environment" (Site 1). On each replication plot, three samples core were taken from the 0-20cm layer along the diagonal and were subjected to physicochemical analysis. The organic status (Total C, N and C/N ratio), physical properties (particle size distribution, texture, moisture content), chemical indexes (Séch, CEC, pH, V, Conductivity) and major nutrients (NO3-, NH4+, K+, Mg2+, Ca2+, Total P) were evaluated. The results obtained revealed that the treatment with the induced biocrust increased the rates of C, N, Séch, CEC, V, pH, NH4+, P and clay fraction, with much higher moisture. Taking into account the level of soil degradation, the balance on the site 1 presented the highest positive values in N, clay, pF4.5, Sech, CEC, pH, and P. On the site 2 and site 3, the results balance is sometimes positive or negative depending on the considered soil properties. Then the level of soil degradation influenced the biocrust efficiency, but in general the use of induced biocrust led to an improvement in the physicochemical properties of degraded soils especially on some major nutrients such as N and P. Soils in Burkina Faso like the others Sahelian countries are mostly deficient in these major nutrients. The induced biocrusts seem to be as a sustainable management tool for drylands agrosystems.
Identifying Constraints Perceived by Farmers Practicing Groundnut Cultivation in Odisha, India
Authors: Giri Priyanka Priyadarsani , Mohanty Bijoy Kumar , Acharya Saumyesh , Kumar Bikram
Published: January 2025

Background: The groundnut cultivation also presents challenges such as climate change, appropriate seed selection, and land preparation techniques, which have a significant impact on groundnut production and need the adoption of new technology.
Aims: The present study identifies the constraints faced by the respondents in groundnut cultivation in Balasore district of Odisha, India.
Study Design: Ex post facto research design.
Place and Duration of Study: The study was carried out from the first week to the fourth week of May 2023.
Methodology: The random sampling approach was used to pick one hundred twenty (120) respondents from three blocks in Odisha's Balasore district. A structured interview schedule was prepared to collect the data. Personal interview was conducted to collect the primary data. Data analyses was done to find out the mean score values of each statements using Microsoft Excel Software and then ranking of statements was done.
Results: The results revealed that insufficient training for Knowledge and skill enrichment availability of choice able variety, not giving timely guidance and expertise and lack of transparency in marketing system were some of the the major constraints faced by the respondents.
Conclusion: For improving the production & productivity of groundnut, a need-based action plan for the betterment of farmers in particularly groundnut growers in the state has to be formulated and the constraints such as timely allocation of resources, proper credit facilities and awareness about management practices among others has to dealt with.
Systematic Review and Meta-Analysis of Hibiscus sabdariffa in Hypertension Management
Authors: Obu Raphael Nyarkotey
Published: January 2025

This study systematically reviews and meta-analyzes existing evidence on the efficacy of Hibiscus sabdariffa in managing high blood pressure. A comprehensive search of databases, including PubMed, Scopus, and Web of Science, identified randomized controlled trials and observational studies published between 2010 and 2024. The included studies were evaluated for quality using established criteria, and data were synthesized through meta-analysis using RevMan software.
The analysis demonstrated a statistically significant reduction in both systolic and diastolic blood pressure in individuals treated with Hibiscus sabdariffa extracts compared to placebo. These findings suggest that Hibiscus sabdariffa may serve as an effective adjunctive therapy for hypertension management, highlighting its potential as a natural, non-pharmacological option for controlling blood pressure.
However, the review emphasizes the need for further research to determine the long-term effects, optimal dosages, and standardization of Hibiscus sabdariffa extracts to ensure consistent clinical outcomes. Future studies should prioritize well-designed, large-scale randomized trials across diverse populations to validate these findings and establish evidence-based treatment guidelines. Additionally, further investigation into the herb's mechanism of action, safety profile, and potential interactions with other antihypertensive medications is critical.
This review offers valuable insights into the potential use of Hibiscus sabdariffa as a complementary approach to hypertension treatment while underscoring the importance of advancing research in this area.
Insight in the Management of Traumatic Isolated Injury to Submandibular Gland: A Case Report
Authors: Sequeira Joyce P. , Batra Akshit
Published: January 2025

Rationale: Isolated submandibular gland injuries are infrequent and are mainly reported in the context of trauma.
Patient Concerns: A 32-year-old male patient presented to the ER with a history of self-fall following which there was a penetrating injury to the lower part of the right neck region.
Diagnosis: A diagnosis of soft tissue penetrating injury to the right submandibular gland was made, after a thorough patient history, vigilant clinical examination along with negative CT scan findings.
Intervention: A decision of wound debridement and exploration under local anesthesia was made, with layered closure being done. The postoperative period of the patient was managed with antibiotics, a course of oral glycopyrrolate, three times a day for 5 days, and pressure dressing to address the salivary leak.
Outcomes: The patient was followed up for one year without any evidence of recurrences.
Take-away Lessons: Presentation of isolated submandibular gland injury is unique but rare and should be diagnosed at the earliest to avoid any long-term complications.
Improvement Of FTO/ZnO Schottky Diodes Working Profile Using Magnesium Doping For Conventional Radiology Detector
Authors: Saputra Heru , Sutanto Heri , . Sugianto
Published: January 2025

The Schottky barrier diode formed from FTO substrate and ZnO semiconductor has the potential to be used as a
conventional radiology X-ray detector. The addition of magnesium as a semiconductor dopant has been proven
to enhance the detector's performance in the mid-range energy X-ray. The improvement is also supported by
UV-Vis spectroscopy results, which show an increase in the energy band gap of 0.04 eV. With a firing voltage of 0.17 V, the detector becomes more responsive, and the stability of the current response is also observed.
The Effectiveness Of Personalized Advertising Strategies In Improving Customer Engagement And Conversions In Liberia
Authors: Johnson Samuel
Published: January 2025

The paper aims at examining the effectiveness of personalized advertisements in engaging the Liberian consumers
and converting them into customers due to the increasing trendiness of Digital Advertising in Liberia. This paper
explores how personalized adverting is functionality help in developing deep and values consumer-brand
relationship but on a flip side they raise issues to do with privacy and protection of information. Our study results
concluded that personalized ads strategies had a significant positive relationship with customer conversion in
Liberia. Also, personalized ads strategies increase customer engagements which promotes customer conversion.
Furthermore, the study highlighted 4 main challenges facing organization using personalized ads strategies in
Liberia with majority of respondents mentioning cost of personalization marketing strategy, followed by
technological complexity, data availability and privacy and ethical concerns. The study recommended strategies
to solve the dilemma of offering appropriate personalization to customers in a way that will not harm their trust
as more consumers become informed about data privacy in Liberia. This entails determining the effect that personalized ads generate in terms of customers’ participation, the relationship between personalization and sales, and various ethical issues that personalize ads present.
The Relationship Between Relational Ties, Absorptive Capacity, And Social Integration Mechanisms In Small Retail Businesses Associated With Direct And Indirect Horizontal Networks.
Authors: Piekas Andrezza Aparecida Saraiva , Carvalho Carlos Eduardo
Published: January 2025

Background: The objective of this research is to investigate the relationship between relational ties, absorptive
capacity, and social integration mechanisms in small retail businesses associated with direct and indirect
horizontal networks.
Materials and Methods: To achieve the objective, an empirical research study with a quantitative approach was
conducted involving 409 retail businesses associated with direct and indirect horizontal networks. The proposed
relationships were tested using the structural equation modeling technique.
Results: The results indicate that a company's participation in direct horizontal networks has a greater positive
impact on relational ties and absorptive capacity than participation in indirect horizontal networks. They also
suggest that the use of different types of social integration mechanisms affects the relationship between relational
ties and the company's absorptive capacity in different ways.
Conclusion The research proves that relationships foster a company's absorptive capacity. It particularly,
indicates that it is not just maintaining relationships with other network members that impacts absorptive
capacity, but the type of relationship established between network members (direct or indirect) should be
considered, as direct relationships have proven to be more favorable. There is sufficient evidence to assert that by investing in interorganizational relationships, the company can enhance its absorptive capacity and thus access various other competitive advantages
Forms Of Disclosure Of Environmental Liabilities Demonstrated By Companies In The Electricity Sector
Authors: Barros Paula Cristiane Rodrigues Azevedo , Miranda Jose Fernando Bezerra
Published: January 2025

The present project aimed to present the forms of disclosure of the environmental liabilities demonstrated in
companies in the electricity sector, conceptualizing its origin and presentation model. In view of this, a field
research was carried out through a questionnaire with a total of 9 representatives of the electricity sector linked
to accounting, located in 9 states of the country. The analysis was carried out with emphasis on the theory based
on books and articles on environmental liabilities and relating to the practice exercised in the management of
these organizations. Through the study carried out, it is perceived that there is knowledge about environmental liabilities, but the evidence and measurement are not always done correctly and, many times, they end up not assuming the wear and tear caused to the environment.
Aplicação De Inferência Fuzzy Para Tomada De Decisão Em Processos De SMT No Polo Industrial De Manaus
Authors: Leite Herbety Lima , Alencar David Barbosa De , Alves Hellen Lima Leite , Campos Paola Souto , Morães Nadime Mustafa
Published: January 2025

A Tecnologia de Montagem de Superfície (SMT) é amplamente utilizada na produção de componentes
eletrônicos, especialmente no Polo Industrial de Manaus (PIM), um dos maiores centros de produção
eletrônica do Brasil. Contudo, sua complexidade e sensibilidade a variações de parâmetros, como temperatura
e alinhamento, apresentam desafios significativos à precisão e consistência do processo. Métodos tradicionais
de controle, como o PID, muitas vezes falham em atender às demandas de adaptabilidade e eficiência
requeridas nesses cenários. A lógica fuzzy surge como uma alternativa promissora, oferecendo suporte em
situações de incerteza e variabilidade. Este estudo desenvolveu e implementou um sistema de inferência fuzzy
para o controle de parâmetros críticos em processos SMT no PIM. A metodologia envolveu a identificação de
variáveis chave, como temperatura e pressão, e a construção de um modelo fuzzy baseado em regras
linguísticas e conhecimento especializado. O sistema foi validado por meio de análise comparativa antes e
depois de sua implementação, avaliando aspectos como eficiência produtiva, taxa de retrabalho e qualidade
final dos produtos. A aplicação do sistema fuzzy resultou em melhorias significativas na eficiência do processo
SMT. Observou-se uma redução nas falhas de montagem, menor necessidade de retrabalho e maior
consistência na produção. Além disso, o sistema demonstrou maior capacidade de adaptação a variações
operacionais em comparação aos métodos tradicionais de controle, contribuindo para uma produção mais
sustentável e eficiente. O uso de sistemas de inferência fuzzy em processos SMT no PIM provou ser uma
abordagem eficaz para otimizar a tomada de decisão, melhorando a qualidade e a eficiência produtiva. Esta
pesquisa reforça o papel da lógica fuzzy como uma ferramenta viável para atender às demandas da Indústria 4.0, promovendo inovações em automação industrial e contribuindo para a competitividade das empresas do PIM.
How TechnologyAffects The Knowledge Management Cycles:AStudy Of The Past, Present,And Future Impacts
Authors: Mendes Naamã , Bortolozzi Flávio , Tenório Nelson
Published: January 2025

Artificial intelligence (AI) and Big Data are fundamentally transforming the way we live, impacting not only
daily life but also the manner in which organizations acquire, communicate, and generate knowledge. This
transformation is deeply embedded in contemporary society and carries significant implications for knowledge
management (KM). In recent years, a dominant knowledge management framework has been widely recognized
as an effective approach for mapping the knowledge management cycle. This is exemplified by Dalkir's model,
elaborated in his work "A Holistic Vision of the Knowledge Management Cycle". The emergence of AI and Big
Data raises critical questions about the traditional paradigms of the knowledge management cycle. How does
the integration of these technologies reshape our understanding of knowledge acquisition, dissemination, and
creation within the framework of the knowledge management cycle? Further exploration is required to assess how AI-driven automation and data analytics alter the processes outlined in Dalkir's model, particularly in the context of organizational decision-making and innovation.
Ações Antrópicas E A Associação Com As Mudanças Climáticas
Authors: Ayoub Julianno Pizzano , Oliveira Marcel Ricardo Nogueira De , Freita Fabricio Hernandes De , Mello Mikel Eduardo De
Published: January 2025

Esta pesquisa teve como objetivo analisar as ações antrópicas que contribuem para as mudanças climáticas,
investigando a relação entre atividades humanas, como emissão de gases de efeito estufa, desmatamento e
práticas agrícolas, e o agravamento do aquecimento global, com ênfase nos impactos em ecossistemas e
populações humanas. A metodologia adotada foi uma pesquisa bibliográfica, que envolveu levantamento de
fontes em plataformas acadêmicas como SciELO, Scopus e Google Acadêmico, além de repositórios brasileiros.
Utilizou-se a técnica de leitura flutuante para identificar informações relevantes e realizar uma análise crítica
dos estudos selecionados. Os resultados indicaram que as atividades humanas, especialmente a queima de
combustíveis fósseis, o desmatamento e a agricultura intensiva, são as principais responsáveis pelas mudanças
climáticas, resultando em fenômenos climáticos extremos, como secas, ondas de calor e furacões mais intensos.
A pesquisa conclui que a adoção de estratégias de mitigação, como a redução das emissões de gases, o uso de energias renováveis, a agricultura sustentável e o reflorestamento, são essenciais para reduzir os impactos das mudanças climáticas e garantir um futuro sustentável.
Quantifying regional α ‐synuclein, amyloid β, and tau accumulation in lewy body dementia
Authors: Miller Rebecca L. , Dhavale Dhruva D. , O’Shea Jennifer Y. , Andruska Kristin M. , Liu Jialu , Franklin Erin E. , Buddhala Chandana , Loftin Susan K. , Cirrito John R. , Perrin Richard J. , Cairns Nigel J. , Campbell Meghan C. , Perlmutter Joel S. , Kotzbauer Paul T.
Published: January 2022

Objective

Parkinson disease (PD) is defined by the accumulation of misfolded α‐synuclein (α‐syn) in Lewy bodies and Lewy neurites. It affects multiple cortical and subcortical neuronal populations. The majority of people with PD develop dementia, which is associated with Lewy bodies in neocortex and referred to as Lewy body dementia (LBD). Other neuropathologic changes, including amyloid β (Aβ) and tau accumulation, occur in some LBD cases. We sought to quantify α‐syn, Aβ, and tau accumulation in neocortical, limbic, and basal ganglia regions.

Methods

We isolated insoluble protein from fresh frozen postmortem brain tissue samples for eight brains regions from 15 LBD, seven Alzheimer disease (AD), and six control cases. We measured insoluble α‐syn, Aβ, and tau with recently developed sandwich ELISAs.

Results

We detected a wide range of insoluble α‐syn accumulation in LBD cases. The majority had substantial α‐syn accumulation in most regions, and dementia severity correlated with neocortical α‐syn. However, three cases had low neocortical levels that were indistinguishable from controls. Eight LBD cases had substantial Aβ accumulation, although the mean Aβ level in LBD was lower than in AD. The presence of Aβ was associated with greater α‐syn accumulation. Tau accumulation accompanied Aβ in only one LBD case.

Interpretation

LBD is associated with insoluble α‐syn accumulation in neocortical regions, but the relatively low neocortical levels in some cases suggest that other changes contribute to impaired function, such as loss of neocortical innervation from subcortical regions. The correlation between Aβ and α‐syn accumulation suggests a pathophysiologic relationship between these two processes.
3D Printed Template‐Directed Assembly of Multiscale Graphene Structures
Authors: Zhou Jingzhuo , Wu Xin , Chen Yan , Yang Chuang , Yang Rui , Tan Junyang , Liu Yilun , Qiu Ling , Cheng Hui‐Ming
Published: January 2022

The assembly of different levels of structure from the nano‐ to the macroscale has produced materials with outstanding performance. Here, using graphene as a model building block, the fabrication of multiscale structures is reported, with tailorable features spanning seven orders of magnitude in size by a 3D printed template‐directed assembly method which combines the ability to customize structures from the meso‐ to macroscale using digital light processing and from the nano‐ to microscale using self‐assembly. It is shown that by a careful design of the structures, a number of extraordinary properties can be produced including ultralow density (≥0.08 mg cm–3), and ultrahigh stiffness, and compressibility (full recovery from 95% strain). The approach not only provides diversified structure control over wide length scales for nanomaterial assembly but also shows the possibility of changing the properties of the structure for different applications.
Specific Adsorption Reinforced Interface Enabling Stable Lithium Metal Electrode
Authors: Wang Yu‐Yang , Gu Jian‐Kang , Zhang Bo‐Hai , Li Guo‐Ran , Liu Sheng , Gao Xue‐Ping
Published: January 2022

Lithium‐metal (Li) electrode has been regarded as an excellent option to increase the energy density of next‐generation secondary batteries due to its low electrochemical potential and ultrahigh theoretical capacity. However, Li electrodes suffer from poor Coulombic efficiency (CE) and uneven lithium deposition issues during cycling that severely restrain its application. Herein, ammonium perfluoro(2‐methyl‐3‐oxahexanoate) (APFA), a pragmatic anionic surfactant, is introduced as an electrolyte additive to regulate the deposition behavior of lithium. Different from the conventional sacrificial additives that reinforce solid electrolyte interphase (SEI) layers on Li electrodes, the PFA− anions are mainly adsorbed on the Li surface, which improves the electron transfer step kinetics due to the ψ1 effect. The introduction of APFA in the electrolyte promises homogeneous and highly dense lithium deposition and the LiLi symmetric cell with APFA can operate over 4000 h with excellent stability and low polarization. This work provides a facile and promising strategy for fabricating stable Li anode for high‐energy‐density secondary batteries.
Microneedle Arrays for Drug Delivery and Diagnostics: Toward an Optimized Design, Reliable Insertion, and Penetration
Authors: Ebrahiminejad Vahid , Prewett Philip D. , Davies Graham J. , Faraji Rad Zahra
Published: January 2022

In the past two decades, microneedles have been extensively studied for transdermal delivery of drug or vaccines and for bio‐fluid extraction. Microneedle‐based devices consist of micron‐size needles that are arranged on a small patch. Despite ongoing advances in microneedle technology, one of the major problems associated with transdermal delivery or sampling is that many of the microneedle patches are not able to fully penetrate the skin surface and reach the epidermis layer of skin. In this regard, for an optimal and effective penetration—painless and safe—it is crucial to consider complex skin mechanics and how it impacts microneedle design and insertion practice. Various types of skin modelling and insertion simulations are considered, followed by discussion of ways of improving microneedle robustness, reduction of insertion force, and enhancement of penetration efficiency.
Application of a c‐Si Solar Cell with a Three‐Dimensional Structure to Indoor Photovoltaics
Authors: Sim Yeon Hyang , Yun Min Ju , Lee Dong Yoon , Cha Seung I.
Published: January 2022

As individual photovoltaic (PV) power sources for indoor conditions, various types of solar cells including organic, perovskite, and dye‐sensitized devices, have been used because they provide better performance under weak lighting conditions; however, they are limited in terms of durability and applicability to larger‐sized cells and modules. Crystalline silicon (c‐Si) solar cells address these issues as an economical alternative. Here, to overcome low performance under weak lighting conditions, such as indoor lighting, a three‐dimensional structured c‐Si solar cell is developed to enhance the surface area of the cell for improved indirect light acquisition. With our design prototype, the power output increases by nearly two‐fold using a tetrahedron‐structured c‐Si solar cell compared to its flat two‐dimensional counterpart. Further improvements in the power output are expected to be achieved for the 3‐D c‐Si solar cell by minimizing mismatch losses, which is a common problem associated with this PV device.
Synthesis of Fast Curing, Water‐Resistant and Photopolymerizable Glass for Recording of Holographic Structures by One‐ and Two‐Photon Lithography
Authors: Mikulchyk Tatsiana , Oubaha Mohamed , Kaworek Alicja , Duffy Brendan , Lunzer Markus , Ovsianikov Aleksandr , E‐Gul Sabad‐ , Naydenova Izabela , Cody Dervil
Published: January 2022

Advancements in hybrid sol‐gel technology have provided a new class of holographic materials as photopolymerizable glasses. Recently, a number of photosensitive glass compositions with high dynamic range and high spatial resolution have been reported and their excellent capability for volume holography has been demonstrated. Nevertheless, challenges remain, particularly in relation to the processing time and environmental stability of these materials, that strongly affect the performance and durability of the fabricated holograms. State‐of‐the‐art photopolymerizable glasses possess long curing times (few days) required to achieve thick films, thus limiting the industrial implementation of this technology and its commercial viability. This article presents a novel, fast curing, water‐resistant, photopolymerizable hybrid sol‐gel (PHSG) for holographic applications. Due to introducing an amine‐based modifier that increases the condensation ability of the sol‐gel network, this PHSG overcomes the problem of long curing time and can readily produce thick (up to a few hundred micrometers) layers without cracking and breaking. In addition, this PHSG exhibits excellent water‐resistance, providing stable performance of holographic gratings for up to 400 h of immersion in water. This finding moves photopolymerizable glasses to the next development stage and renders the technology attractive for the mass production of holographic optical elements and their use across a wide number of outdoor applications.
The Second Excited Triplet‐State Facilitates TADF and Triplet–Triplet Annihilation Photon Upconversion via a Thermally Activated Reverse Internal Conversion
Authors: Zhao Yanliang , Wu Yingnan , Chen Wenlong , Zhang Ruiling , Hong Gaobo , Tian Jiarui , Wang Honglei , Zheng Daoyuan , Wu Chenyu , Jiang Xiao , Huo Xinming , Sun Lei , Deng Weiqiao , Han Keli , Song Fengling
Published: January 2022

Recent years have seen a surge in organic emitters that exhibit thermally activated delayed fluorescence (TADF) behavior owing to their high exciton utilization efficiency, low biological toxicity, etc. However, the existing TADF channel is insufficiently well developed as to design high‐performance materials especially in the high‐lying triplet state mediated reverse intersystem crossing process. A thermally activated reverse internal conversion (TARIC) pathway is reported here, which can achieve effective population transfer from T1 to T2 states via conical intersection point with the barrier of 3.81 kcal mol−1. On this basis, the mediated T2 state facilitates the TADF and triplet–triplet annihilation photon upconversion (TTA–UC) channel. Furthermore, benefited from the TARIC pathway, the designed 2′,7′‐dichlorofluorescein (DCF) derivative DCF−MPYM−Me photosensitizer presents an excellent upconversion efficiency of 13.6%. The high upconversion efficiency is the best performance in purely organic TADF photosensitizers without heavy atoms in TTA−UC systems.
Acousto‐Optic Modulation in Silicon Waveguides Based on Piezoelectric Aluminum Scandium Nitride Film
Authors: Huang Chukun , Shi Haotian , Yu Linfeng , Wang Kang , Cheng Ming , Huang Qiang , Jiao Wenting , Sun Junqiang
Published: January 2022

Aluminum scandium nitride (AlScN) has attracted extensive attention for its excellent piezoelectric properties in the micro‐electromechanical system applications. In this work, AlScN is demonstrated to be a promising candidate for on‐chip acousto‐optic coupling interactions with outstanding piezoelectric properties as well. Based on piezoelectric Al0.6Sc0.4N film deposited on silicon‐on‐insulator platform, the proposed devices exhibit impressive acousto‐optic coupling performances over a short interaction length of 210 µm with surface acoustic waves actuated by interdigital transducers. Meanwhile, the acousto‐optic coupling performances are further improved in a compact spiral waveguide with eight interaction segments, where the measured modulation efficiency is enhanced from −21.5 to −12.5 dB and the radiofrequency (RF) 3‐dB bandwidth is narrowed from 4 to 3.1 MHz at central frequency of 3.044 GHz with RF drive power of 18.6 dBm. The measured modulation efficiency is proportional to the incident RF drive power, depicting a linear increasing trend with a slope of one as the RF power increases up to 24.6 dBm. Such acousto‐optic devices are capable of achieving broadband acousto‐optic modulation and narrow‐band microwave photonic filtering. Besides, the designed device structure provides a prospect in single‐sideband modulation, acousto‐optic frequency shift, and nonreciprocal light propagation.
Palladium‐Catalyzed Alkynylation of Alkenes via C−H Activation for the Preparation of Conjugated 1,3‐Enynes
Authors: Guo Li‐Yun , Li Qing , Liu Yu‐Tao , Li Lin , Ni Yu‐Qing , Li Yang , Pan Fei
Published: January 2022

A general palladium‐catalyzed method for the direct alkynylation of unactivated alkenes via C−H activation, was successfully developed, with the assistance of 8‐aminoquinoline. It is applicable to both internal and terminal unactivated alkenes with a broad functionality tolerance. This method shows good regio‐ and diastereoselectivity and provides an alternative approach for directing construct of conjugated 1,3‐enynes.

magnified image
Cross‐Electrophile Coupling between Aryl/Vinyl Triflates and Vinyl Tosylates for the Synthesis of gem‐Difluoroalkenes via Ni/Pd Cooperative Catalysis
Authors: Xiong Baojian , Li Yue , Zhang Jinyu , Liu Jiangjun , Zhang Xuemei , Lian Zhong
Published: January 2022

A dual nickel‐/palladium‐catalyzed direct gem‐difluorovinylation of readily available aryl/vinyl triflates with substituted gem‐difluorovinyl tosylates is presented. This protocol affords various diaryldifluoroalkene, arylalkyldifluoroalkene and 1,1‐difluoro‐2‐substituted‐1,3‐dienes under mild reaction conditions with excellent functional group compatibility, and provides a potential pathway to the late‐stage functionalization of complex bioactive molecules.

magnified image
Refining the clinical phenotype associated with missense variants in exons 38 and 39 of KMT2D
Authors: Tharreau Mylène , Garde Aurore , Marlin Sandrine , Morel Godelieve , Ernest Sylvain , Nambot Sophie , Duffourd Yannis , Ternoy Ninon , Duvillard Christian , Banka Siddharth , Philippe Christophe , Thauvin‐Robinet Christel , Mau‐Them Frederic Tran , Faivre Laurence
Published: January 2022

Loss‐of‐function variants in KMT2D are responsible for Kabuki syndrome type 1 (KS1). In the last 5 years, missense variants in exon 38 or 39 in KMT2D have been found in patients exhibiting a new phenotype with multiple malformations and absence of intellectual disability, distinct from KS1. To date, only 16 cases have been reported with classic features of hearing loss, abnormality of the ear, lacrimal duct defects, branchial sinus/neck pits, choanal atresia (CA), athelia, hypo(para)thyroidism, growth delay, and dental anomalies. We report here two families and one unpublished variant, refining the clinical and molecular knowledge on this new entity. Family 1 presented with apparently isolated autosomal dominant choanal atresia, in eight members across three generations. Exome sequencing (ES) in the proband and one cousin revealed a p.Glu3569Gly variant in exon 38 of KMT2D, segregating with choanal atresia in the family. Clinical reevaluation evidenced thyroid dysfunction, mild hearing anomalies, and hypoplastic nipple in some patients. Family 2 presented with nasolacrimal duct obstruction, hearing loss, mild facial features, unilateral axial polydactyly, and unilateral toe V‐VI syndactyly. ES revealed a de novo already reported p.Arg3582Gln variant in exon 38 of KMT2D. Considering these results and the existing literature, we suspect that missense variants in exon 38 of KMT2D are responsible for phenotypes that are even milder (isolated CA) and broader (polydactyly) than what has been previously described.