bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of curative effect of percutaneous autologous bone marrow cell transplantation for treating nonunion under laser positioning and navigation guidance
Authors: Zhang Hongyue , Xia Demeng , Wu Jianghong , Hao Zichen , Wang Panfeng , Xu Shuogui , Zhang Yuntong
Published: March 2021

Fracture end cleaning, local bone grafting, and fixation are the classic treatment methods for fracture nonunion, but patients normally need to wait for a long time to ensure that there are signs of further healing. The purpose of this research is to verify whether precision injection
improvement can be developed as treatment associated with autologous bone marrow cell injection to promoting fracture healing. The curative effect of traditional autologous bone marrow injection for the treatment of poor fracture healing is affected by injection accuracy and locally available
cell retention the clinical. The curative effect of autologous bone marrow injection can be effectively improved through autologous bone marrow centrifugation and bone grinding at fracture end when combined with preoperative three-dimensional computed tomography (CT) planning. This minimally
invasive treatment method is especially suitable for patients with delayed fracture healing within six months of presentation. Patients with nonunion over six months can be treated with improved autologous bone marrow injection. The convenient and minimally invasive method itself will not
be difficult for patients, physically and mentally, and the most reliable treatment method for nonunion is to cut and clean hardened bone and implant autologous bone fixation.
Rapid physical preparation of a superhydrophobic surface on copper foil without low-surface-energy materials coating
Authors: Wang Jian , Chen Hong , Li Xinyuan
Published: March 2021

A method is proposed to directly obtain superhydrophobic properties by depositing a coating made of candle soot upon the copper foil surface. The process to prepare a surface of superhydrophobicity is simple and rapid, which was performed just by placing the copper foil over the flame
of a burned candle for no more than 10 minutes. The surface contact and slide angles of water were 159° ± 1.8° and 2°, respectively. Furthermore, the wettability on the copper surface of superhydrophobicity was also investigated. We found that the copper superhydrophobic
surface prepared by the method had excellent superhydrophobicity for water; acid, alkali and salt solutions; and other liquids. In contrast to the traditional approach to prepare superhydrophobic surfaces, the method proposed in this study not only did not damage the mechanical properties
of the substrate surface but also did not require low surface energy materials to be modified. This study provides a new approach for the protection of copper and other metallic materials.
Temperature-sensitive poly(N-isopropylacrylamide) (PNIPAAm) stabilized size controllable synthesis of silver nanoparticles and its improved antimicrobial activity for wound healing and nursing care after femoral fracture during surgery
Authors: Wang Xiaoyun , Zhang Jing
Published: March 2021

In this research, a thermo-sensitive copolymer PNIPAAm-co-MHq was used to successfully synthesize different nano sizes silver nanoparticles in the ranges between 1.5 to 4 nm with uniform dispersion. The polymeric assisted synthesized Ag nanoparticles (AgNPs@PM) exhibited reasonable
solution stability and thermalresponsive behaviour. In specific, AgNPs@PM3 (1.59 nm) displayed improved bacterial resistance against clinically approved anti-biotic resistant bacterial pathigens with very low MIC value (4.05 μg/mL). Subsequently, the thermal responsive
polymeric molecular structure on AgNPs synthesis has been established that significant temperature dependened anti-bacterial efficiency. It was also observed that the nonparticipants size, temperature responses and proportion of thermosensitive copolymer also influenced the antibacterial efficacy
of AgNPs@PM. Resulting thermal sensitive polymer nanocomposite can be extremely beneficial for wound healing treatment after femoral fracture surgery.
Synergic combination of paclitaxel and irinotecan loaded poly(lactic-co-glycolic acid) nanocomplexes for MRI and the treatment of endometrial cancer
Authors: Chen Min , Zhou Qi , Chen Can , Liu Yanlin , Wang Xueling
Published: March 2021

We have established dual paclitaxel (PTX)/superparamagnetic iron oxide (SPIO)-loaded PLGA-based nanoparticles for theranostic purposes. The fabricated nanoparticles exhibited a spherical morphology with a size of ∼240 nm. The PTX and iron loading were 1.84 ± 0.4 and 10.4
± 1.93 mg/100 mg, respectively. The relaxometry studies and phantom magnetic resonance imaging demonstrated their efficacy as T2 contrast agents. A significant cellular uptake of nanoparticles by the endometrial Ishikawa cells was demonstrated using confocal laser scanning
microscopy. While SPIO did not show any toxicity in endometrial Ishikawa cells, PTX-loaded nanoparticles indicated cytotoxic activity. Together, these advantages of multifunctional nanoparticles may be considered as future nanomedicines for simultaneous molecular imaging, drug delivery, and
real-time monitoring of therapeutic response.
Evaluation of infrared thermography combined with drug-loaded superparamagnetic nanoparticles for the diagnosis and treatment of breast cancer
Authors: Yu Cunguo , Zhang Lixin , Liu Jinying , Wang Xiaoguang
Published: March 2021

Breast cancer (BC) is a common malignant tumor that threatens both the physical and mental health of women worldwide, the incidence of BC is increasing each year. Early detection and prompt diagnosis are key for prevention of BC and will promote reductions in morbidity and mortality.
As such, we present here an integrated diagnostic and treatment strategy for BC that is based on infrared thermal imaging (IRTI) combined with superparamagnetic iron tetroxide (Fe3O4) nanoparticles. In this work, a doxorubicin (DOX) anticancer drug platform was generated
using polyethylene-coated paramagnetic nano-iron tetroxide particles, and IRTI technology was used to implement an integrated approach to diagnosis and treatment. The therapeutic efficacy of the DOX anticancer drug system utilizing nano-iron tetroxide superparamagnetic particles was examined.
DOX anticancer drug composite nanomaterials based on superparamagnetic Fe3O4 nanoparticles (PEG-Fe3O4@DOX). The size distribution of NPs was 14.5 ± 0.53 nm, and the drug encapsulation rate (80.1%) and drug loading rate (35.3%) were higher
PEG-Fe3O4@DOX. The results showed that the acidic medium was beneficial to the release of DOX PEG-Fe3O4@DOX. It is beneficial to release DOX from NPs PEG-Fe3O4@DOX NPs can accurately reach the cancerous site for release and
achieve the purpose of precise treatment.
Influence of different but compatible all-ceramic materials and bonding systems on dentin bonding properties
Authors: Luo Aoxiang , Yao Yao , Zhang Li , Chen Yuejing
Published: March 2021

This study aimed to investigate the effects of various compatible all-ceramic materials and bonding systems, on the bonding properties of dentin. Five types of commonly used all-ceramic materials (Cerec Blocs, IPS e. max Press, IPS e. max ZirCAD, Incoris Alumina, In-Ceram Alumina) were
bonded with three types of adhesives (Multilink N, Variolink N, Relyx Unicem) for nuclear porcelain tile preparation. We evaluated the polymerization conversion rates, shear bonding strength (SBS), and micro-tensile bond strength (TBS) for each combination. The polymerization conversion rates,
SBS and TBS differed significantly for all 3 adhesives with each all-ceramic group (P < 0.05). The Relyx Unicem agent had higher adhesive properties compared with the Variolink N and Multilink N agents (P < 0.05). The polymerization conversion rate, SBS and TBS of the five
all-ceramic materials differed significantly with each adhesive (P < 0.05). The Cerec Blocs had the highest adhesive performance (P < 0.05). The polymerization conversion rate of adhesives differed with each all-ceramic material, while the dentin bonding strength differed
with each all-ceramic material and adhesive. Clinically, all-ceramic materials with a high transparency and low refraction are recommended. For opaque all-ceramic restorations, the curing light time and polymerization reaction rate should be increased to improve the dentin bonding performance.
Fabrication and characterization of polyvinyl alcohol/chitosan/moringa-extract hydrogel patch for wound-healing applications
Authors: Naqvi Syeda Mahrukh Kamal , Khan Zara , Mirza Eraj Humayun , Chandio Alidad , Manzoor Farina , Niaz Rida , Khan Aftab Ahmed , AlKhureif Abdulaziz Abdullah
Published: March 2021

In this study, a wound-healing patch containing polyvinyl alcohol (PVA), chitosan (CH) and moringa-oleifera-leaf extract (MOR) blends was prepared. PVA prepolymer (2%) was prepared at 80 °C using a hot-plate magnetic stirrer. Four samples (6 ml-films) of PVA prepolymer with a combination
of CH powder (0.5%, PVA+ CH), moringa-leaf extract (2.5%, PVA+ MOR), and both CH and moringa (0.5% and 2.5%, PVA+ CH+ MOR) were prepared using the freeze-thaw method at –40 °C. The tests were conducted with pure PVA as the control group. The physicochemical characteristics were assessed
by compound-microscopy, Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), tensile-strength test using universal testing machine (UTM), and X-ray diffraction (XRD). The water contact angles measured using ImageJ software
proved the hydrophilicity of the fabricated biomaterial, showing watercontact angle 37.55° of PVA+ CH+ MOR. The results of the degradation test using phosphate buffer saline (PBS) also indicate that the CH biopolymer enhances the biodegradability of the hydrogel. On addition of chitosan
the degradation temperature increased to 288 °C from 251 °C of pure PVA, while it changed to 302 °C on compounding moringa, proving enhanced strength. The obtained physicochemical properties suggest that the patch combining PVA + CH + MOR can be used as a wound-healing patch.
Clinical practice: intravenous thrombolysis in a patient with active cancer who experienced wake-up stroke
Authors: Wu Siting , Xing Zengluan , Lin Jiacai , Liu Hui , Cui Fang , Xu Rui
Published: March 2021

After reviewing the diagnosis and treatment process of a patient with active cancer who experienced wake-up stroke, we have summarized the clinical manifestations, laboratory examination results, imaging features, pathological results, and treatment in this report. Patients with active cancer who experience wake-up stroke often have mild neurological deficits at the time of onset. For the patient in this study, laboratory test results were mainly characterized by abnormal coagulation function and elevated tumor markers. The brain magnetic resonance imaging (MRI) images were characterized by involvement of both the arterial and venous systems. Thrombolytic therapy during the window period can improve the symptoms of neurological deficits. Overall, anticoagulation therapy was safe and effective in our patient.
Living with hepatitis B virus infection; media messaging matters
Authors: Abraham Susanna Aba , Agyemang Sampson Opoku , Ampofo Evelyn Asamoah , Agyare Elizabeth , Adjei-Druye Andrew , Obiri-Yeboah Dorcas
Published: March 2021

Hepatitis B Virus (HBV) infection is of public health importance due to its high prevalence and infectivity. A positive test for HBV has psychological, emotional, and socio-economic implications that may affect the quality of life of the clients. The media is a major source of information and awareness creation on many health related issues including HBV. This study explored how media messaging on HBV influenced coping among persons infected with HBV. Twelve in-depth interviews were conducted among clients who reported at the STI clinic for routine care at the Cape Coast Teaching Hospital, Ghana. Descriptive content analysis involving deductive and inductive approaches were applied. The findings show that radio was the main source of HBV related information. Misinformation on the transmission, chronicity and prognoses of HBV infection was mostly conveyed by traditional medicine practitioners on the media. These resulted in adverse emotional, social, and physical reactions such as fear and panic, isolation and loneliness, sleeplessness and unsafe health seeking behaviours. However, access to scientific information from health professionals resulted in empowerment and positive coping. More need to be done to regulate the content of HBV-related messages aired so as to avoid misinformation and its consequent negative impact on coping.
Joining of ceramic to metal by friction welding process: A review
Authors: Ahmed Shaik Abrar , Hasanabadi M Fakouri , Kumar A Varun
Published: March 2021

In this paper, the recent progress in friction welding of alumina along with its various composites to metals is thoroughly investigated and compared. Among the existing methods of joining ceramics to metals, the friction welding process seems to be a reliable approach that provides promising joint properties. A relationship is established between processing parameters, their resultant microstructures, and their associated mechanical properties. The material properties and the environmental factors are taken into account while manifesting this comparison. The influence of various factors such as rotations per minute (r/min), friction pressure, and friction time on mechanical properties is critically analyzed. However, several challenges that must be addressed appropriately to achieve these joints and to fabricate the same have been discussed.
Innovative concepts for the usage of veneer-based hybrid materials in vehicle structures
Authors: Heyner DB , Piazza G , Beeh E , Seidel G , Friedrich HE , Kohl D , Nguyen H , Burgold C , Berthold D
Published: March 2021

A promising approach for the development of sustainable and resource-saving alternatives to conventional material solutions in vehicle structures is the use of renewable raw materials. One group of materials that has particular potential for this application is wood. The specific material properties of wood in the longitudinal fiber direction are comparable to typical construction materials such as steel or aluminum. Due to its comparatively low density, there is a very high lightweight construction potential especially for bending load cases. Structural components of the vehicle body are exposed to very high mechanical loads in the case of crash impact. Depending on the component under consideration, energy has to be absorbed and the structural integrity of the body has to be ensured in order to protect the occupants. The use of natural materials such as wood poses particular challenges for such applications. The material characteristics of wood are dispersed, and depend on environmental factors such as humidity. The aim of the following considerations was to develop a material system to ensure the functional reliability of the component. The test boundary conditions for validation also play a key role in this context. The potential of wood–steel hybrid design based on laminated veneer lumber and steel was investigated for use in a component subjected to crash loads such as the door impact beam. The chosen solution involves a separation of functions. A laminated veneer lumber-based beam was hybridized with a steel strip on the tension side. The steel strip was designed to compensate the comparatively low elongation at fracture of the wood and to ensure the integrity of the beam. The wooden component was designed for high energy absorption due to delamination and controlled failure during the impact, while maintaining the surface moment of inertia, i.e. the bending stiffness of the entire component. This approach was chosen to ensure the functional safety of the component, avoid sudden component failure and utilize the high potential of both materials. The tests carried out provided initial functional proof of the chosen solution. The hybridization achieved significantly higher deformations without sudden failure of the beam. In addition, bending capabilities were increased significantly compared to a beam without hybridization. In comparison with a state-of-the-art steel beam, the hybrid beam was not able to achieve the maximum deformation and the target weight of the hybrid beam. Further optimization of the hybrid beam is therefore necessary.
Vitrectomy for laser-induced full-thickness macular hole
Authors: Wang Xin , Zhang Ting , Jiang Rui , Xu Gezhi
Published: March 2021

Background

To report the structure and visual outcomes of pars plana vitrectomy (PPV) for laser-induced full-thickness macular holes (MHs).

Methods

This retrospective study enrolled 10 patients who underwent vitrectomy for MHs caused by laser injury. Best corrected visual acuity (BCVA), macular spectral-domain optical coherence tomography (OCT) and OCT angiography (OCTA) were used for assessment.

Results

Four patients were injured by unexpected expose of an yttrium aluminum garnet (YAG) laser, and six patients were accidentally injured by a handheld laser. The MH minimum diameters (MDs) ranged from 55 to 966 μm (mean = 548.00 ± 286.10 μm), and BCVA ranged from 20/400 to 20/50 (mean = logMAR 0.87 ± 0.29) preoperatively. All 10 eyes underwent PPV, internal limiting membrane (ILM) peeling, and gas tamponade. All eyes demonstrated closure of the MH with different degrees of discontinuity of the outer layer of the retina, and four eyes exhibited serious retinal pigment epithelium (RPE) destruction. Postoperative BCVA values were significantly improved (mean = logMAR 0.55 ± 0.33; P = 0.032, t = 2.234). The mean BCVA of the destroyed RPE group was significantly worse than that of the non-destroyed RPE group both before and after surgery (P = 0.019; Wilcoxon signed rank test). Further, OCTA indicated choroidal ischemia in the laser-induced MHs.

Conclusion

Vitrectomy can be successful in closing laser-induced full-thickness MHs and improving visual acuity. However, If RPE/choroid is involved in laser damage in addition to the outer retinal layer, this may indicate poor visual prognosis.
Socioeconomy as a prognostic factor for location of death in Swedish palliative cancer patients
Authors: Nilsson Jonas , Holgersson Georg , Ullenhag Gustav , Holmgren Malin , Axelsson Bertil , Carlsson Tobias , Bergqvist Michael , Bergström Stefan
Published: March 2021

Background

An important aspect of end-of-life care is the place of death. A majority of cancer patients prefer home death to hospital death. At the same time, the actual location of death is often against patient’s last-known wish. The aim of this study was to analyze whether socioeconomic factors influence if Swedish palliative cancer patients die at home or at a hospital. There is no previous study on location of death encompassing several years in Swedish cancer patients.

Methods

Data was collected from the Swedish Register of Palliative Care for patients diagnosed with brain tumor, lung, colorectal, prostate or breast cancer recorded between 2011 and 2014. The data was linked to the Swedish Cancer Register, the Cause of Death Register and the Longitudinal Integration Database for health-insurance and labor-market studies. A total of 8990 patients were included.

Results

We found that marital status was the factor that seemed to affect the place of death. Lack of a partner, compared to being married, was associated with a higher likelihood of dying at a hospital.

Conclusion

Our findings are in line with similar earlier studies encompassing only 1 year and based on patients in other countries. Whether inequalities at least partly explain the differences remains to be investigated. Patients dying of cancer in Sweden, who do not have a life partner, may not have the option of dying at home due to lack of informal support. Perhaps the need of extensive community support services to enable home death have to improve, and further studies are warranted to answer this question.
The effect of additional protein on lean body mass preservation in post-bariatric surgery patients: a systematic review
Authors: Romeijn Marleen M. , Holthuijsen Daniëlle D. B. , Kolen Aniek M. , Janssen Loes , Schep Goof , van Dielen François M. H. , Leclercq Wouter K. G.
Published: March 2021

Background

As result of bariatric surgery, patients are susceptible to protein deficiency which can result in undesirable lean body mass (LBM) loss. Consumption of high-protein diets or supplements could counteract this, but evidence about the effect is scarce. This paper systematically reviewed the literature to determine the effect of additional protein intake (≥60 g/day) on LBM preservation in post-bariatric patients.

Methods

An electronic search of PubMed, EMBASE and the Cochrane Library was conducted. Studies were included if patients received a high-protein diet or protein supplements for at least one month, and LBM was assessed. The primary outcome was difference in mean LBM loss between the experimental (protein) and control group. Secondary outcomes were differences in body fat mass, total body water, body mass index and resting metabolic rate.

Results

Two of the five included studies (n = 223) showed that consumption of proteins resulted in significant LBM preservation. Only one study reported a significant difference in the reduction of body fat mass and resting metabolic rate in favour of a high-protein diet, but none of the studies showed a significant difference in total body water loss or body mass index change between the two groups.

Conclusions

This paper showed inconclusive evidence for LBM preservation due to protein supplementation or a high-protein diet in post-bariatric patients. This outcome might be subjected to certain limitations, including a lack of blinding and a low compliance rate reported in the included studies. More specific and personalized recommendations regarding protein intake may need to be established by high quality research. Studies investigating the quantity (g/day) and quality (whey, casein or soy) of proteins are also needed.
Cerebral metastasis of Merkel cell carcinoma following resection with negative margins and adjuvant external beam radiation: a case report
Authors: Grubb Alex F. , Hankollari Elizabeth
Published: March 2021

Background

Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine tumor of the skin. It is associated with advanced age, ultraviolet (UV) radiation, and Merkel cell polyomavirus. It has a predilection for the lymphatic system, but rarely spreads to the central nervous system.

Case presentation

A 71-year-old Caucasian man with a history of rheumatoid arthritis and MCC of the right lower eyelid and cheek presented with left-sided hemineglect and word-finding difficulty. Twenty months earlier he had undergone local excision of a 3 cm lesion with negative margins, negative sentinel lymph node biopsy, and external beam radiation. On presentation he was found to have a 6.3 cm mass in the right frontotemporal region. He underwent prompt resection, with pathological analysis consistent with metastatic MCC. He subsequently underwent stereotactic radiosurgery (SRS) and adjunctive immunotherapy with pembrolizumab. He has since tolerated the therapy well and is currently without neurological symptoms or evidence of recurrence.

Conclusions

Cerebral metastasis of MCC is a rare event and should be considered when a patient with a history of MCC presents with neurological symptoms. Optimal treatment regimens of these rare cases are unclear; however, prompt resection, stereotactic radiosurgery, and adjunctive immunotherapy have shown an initial positive response in this patient.
Intestinal mycobiota in health and diseases: from a disrupted equilibrium to clinical opportunities
Authors: Wu Xiaoyan , Xia Yaoyao , He Fang , Zhu Congrui , Ren Wenkai
Published: March 2021

Bacteria, viruses, protozoa, and fungi establish a complex ecosystem in the gut. Like other microbiota, gut mycobiota plays an indispensable role in modulating intestinal physiology. Notably, the most striking characteristics of intestinal fungi are their extraintestinal functions. Here, we provide a comprehensive review of the importance of gut fungi in the regulation of intestinal, pulmonary, hepatic, renal, pancreatic, and brain functions, and we present possible opportunities for the application of gut mycobiota to alleviate/treat human diseases.
The frequency distribution of reported THC concentrations of legal cannabis flower products increases discontinuously around the 20% THC threshold in Nevada and Washington state
Authors: Zoorob Michael J.
Published: March 2021

Background

Cannabis laboratory testing reliability is a scientific and policy challenge in US states with legal cannabis. Greater reported THC concentration yields higher prices, and media reports describe a well-known consumer and dispensary preference for flower products containing a minimum 20% THC content—an economically meaningful but biologically arbitrary threshold. This paper examines the frequency distribution of reported THC concentration in legal cannabis flower products in Nevada and Washington state for unusual shifts around the 20% threshold suggestive of potential manipulation of reported THC results.

Methods

THC concentration test results for 142,000 Chemotype 1 flower products from Washington state between June 2014 and May 2017 and 55,000 flower products from Nevada between December 2017 and January 2020 were analyzed for changes in the frequency distribution around the 20% threshold using the McCrary density test. Analyses were performed among all labs in each state, the highest volume lab in Washington, and two labs in Washington which had their licenses suspended for testing irregularities during the study period.

Results

Comparing just above the 20% THC threshold with just below it, the frequency of test results increased by about 43% in Nevada (z = 15.6, p < 0.001) and by about 17% in Washington (z = 11.0, p < 0.001). In Washington’s highest volume testing lab, frequency increased by only about 1% (z = 0.39, p = 0.70), while it increased by about 47% (z = 12.7, p < 0.001) among the two suspended labs. Subset to those growers which sent products to both sets of labs, frequency of flower products just above the 20% threshold increased by 2% in Washington’s largest lab (z = 0.50, p = 0.62) and by 52% among the two suspended labs (z = 12.8, p < 0.001).

Discussion

There is a statistically unusual spike in the frequency of products reporting just higher than 20% THC in both states consistent with economic incentives for products to contain at least 20% THC. This “bunching” of reported THC levels exists among some, but not all, cannabis testing labs, suggesting that laboratory differences (rather than precise manipulation by growers) drive this potential manipulation in reported THC content. These findings elaborate on prior research highlighting unexplained interlaboratory variation in cannabis testing results and highlight ongoing irregularities with legal cannabis testing.

Conclusion

These findings highlight the need for industry oversight and cautions researchers working with reported cannabis THC concentration data, which may be biased by economic incentives to report higher THC.
Anthracycline-Induced Cardiotoxicity: Molecular Insights Obtained from Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes (hiPSC-CMs)
Authors: Bozza William P. , Takeda Kazuyo , Alterovitz Wei-Lun , Chou Chao-Kai , Shen Rong-Fong , Zhang Baolin
Published: March 2021

Anthracyclines are a class of chemotherapy drugs that are highly effective for the treatment of human cancers, but their clinical use is limited by associated dose-dependent cardiotoxicity. The precise mechanisms by which individual anthracycline induces cardiotoxicity are not fully understood. Human-induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs) are emerging as a physiologically relevant model to assess drugs cardiotoxicity. Here, we describe an assay platform by coupling hiPSC-CMs and impedance measurement, which allows real-time monitoring of cardiomyocyte cellular index, beating amplitude, and beating rate. Using this approach, we have performed comparative studies on a panel of four anthracycline drugs (doxorubicin, epirubicin, idarubicin, and daunorubicin) which share a high degree of structural similarity but are associated with distinct cardiotoxicity profiles and maximum cumulative dose limits. Notably, results from our hiPSC-CMs impedance model (dose-dependent responses and EC50 values) agree well with the recommended clinical dose limits for these drugs. Using time-lapse imaging and RNAseq, we found that the differences in anthracycline cardiotoxicity are closely linked to extent of cardiomyocyte uptake and magnitude of activation/inhibition of several cellular pathways such as death receptor signaling, ROS production, and dysregulation of calcium signaling. The results provide molecular insights into anthracycline cardiac interactions and offer a novel assay system to more robustly assess potential cardiotoxicity during drug development.
РАЗРАБОТКА СИСТЕМЫ УЧЕТА КАДРОВ ДЛЯ ДОРОЖНОГО ПРЕДПРИЯТИЯ
Authors: ZARIPOVA RIMMA , ROCHEVA OLGA
Published: March 2021

The article deals with the problem of operational personnel records and obtaining statistical information for the prediction of further action within the regional division of the road enterprise.
Creation of the professionally important qualities of navigator cadets during training
Authors: Pekar' Elena , Anosov Aleksey , Danchenko Svetlana
Published: March 2021

The paper refers to the issues of navigator cadets trained at the simulator of radar and digital sea-charts. The goal of research is to study the features of the formation of voluntary attention and emotional stability. Voluntary attention and emotional stability are the most important professionally important qualities of operators. The following methods were used: «Red-black table of Gorbov – Schulte», «The scale for assessing the level of reactive and personal anxiety Ch.D. Spielberger and Yu.L. Khanina» («STAI»). Considering the professionally important qualities of a navigator is important for us from the point of view of professional activity being a highly qualified specialists, in an overstrained workplace. The evaluation of respondents' voluntary attention and emotional stability (characteristics of anxiety) is assesed within the paper basing on prediscovery and research after the training program. On the obtained evidence the sampling anxiety level is affected by the simulator training as there are the reducing of reactive anxiety in respondents'. The experience of practical training at sea has a negative correlation with the number of errors made by cadets when performing tasks for attention.
Self-marketing as a way of boost global competitiveness of a teacher
Authors: Egurnova Aleksandra
Published: March 2021

Digital transformation in modern society incessantly increases the growth rate of investment in the cutting-edge information technologies, which greatly affects the quality of products and services provided. The Russian education system, with the priority goal of modernizing it being to update the teaching staff and reconstruct the system of advanced professional training of educators, is also undergoing radical changes. The process of integrating distance technologies into the structure of pedagogical activity makes significant adjustments to the strategy of teaching students, which leads to re-evaluation of professionally and socially meaningful qualities of a teacher for building effective business relations with consumers of educational services and improving self-competitiveness in the labor market. This requires a fundamentally new approach to selecting an individual educational trajectory that will contribute to the successful development of professional competence of a teacher, which, according to the author, can be achieved by implementing self-marketing.

The article considers the author’s scheme of self-marketing of a foreign language teacher developed to assess self-effectiveness – competitive advantages (professionally and socially meaningful qualities) – and provide useful guidelines to fight off competition in the [international] educational industry.
Principles of constructing school textbooks of foreign languages
Authors: Bashlueva Natalya , Bashlueva Mariya
Published: March 2021

The article deals with the creation of a rational system of textbooks, which is the central and at the same time the most difficult problem. Such a task is faced by the methodology of teaching foreign languages both in general education schools and in educational organizations of the Ministry of Internal Affairs system. The most reasonable general guidelines of the methodology and the specific recommendations resulting from them can be effectively implemented only through the medium of a textbook or training manual. At the heart of this rather popular view is a lack of understanding and underestimation of the tasks and difficulties that face the construction of an effective system of language teaching in general and in the conditions of a secondary school or university in particular and in particular. A rational textbook of a foreign language for any purpose can be created only as a result of serious research work that requires a preliminary examination of the sphere of language communication in which we strive to include the student. The demands of modern life for teaching foreign languages dictate the need for a different, more radical approach to the problem of textbooks. A series of school textbooks can fulfill its task only if it is a single coherent system of mastering strictly selected components of oral speech( speaking-listening), reading and writing in the volume established by the program.
The influence of parental attitudes on the formation of the personality of a minor with delinquent behavior
Authors: Teregulova Oxana
Published: March 2021

The article considers the parental attitude as one of the main factors influencing the formation of the personality of a juvenile delinquent with delinquent behavior. The concept of "parental relationship" and its structure are studied. The author analyzes the features of destructive parental attitudes, such as shortcomings in the educational process, emotional alienation of parents, low moral level of families, deviant motherhood.

The differences in the structure of the maternal and paternal relationship are determined. The features of negative relations between parents and minors are described, such as inconsistency, coldness, aloofness, inconsistency, disrespect, and misunderstanding. The authors also consider the causes of deviant motherhood, which consist in psychiatric and intellectual disorders of young women, resulting from violence, abuse in childhood, improper upbringing, as well as due to the influence of social factors, such as the low level of education of women, poverty, and unemployment.

The article is written on the basis of a study conducted on the basis of the methodology for diagnosing parental attitudes developed by A. Ya. Varga and V. V. Stolin, parents of minors with law-abiding and delinquent behavior took part in the survey.

As a result of the study, it was found that parents treated minors with delinquent behavior more coldly, distanced and alienated, and showed little attention to their lives than to law-abiding minors.
SITUATIONAL AND ENVIRONMENTAL APPROACH TO DESIGNING OF THE DEVELOPMENT OF AESTHETIC CULTURE OF EMPLOYEES OF INTERIOR MINISTRY OF RUSSIA
Authors: Gordeeva Ekaterina
Published: March 2021

The relevance of the topic under study is due to the fact that at present, the requirements imposed by society and the state to the level of cultural development of an employee of the internal affairs bodies have indicated the need to develop his aesthetic culture. Analysis of the results of research in the field of legal education, is devoted to the study of the phenomenon of the educational environment ATS as a subsystem of vocational service environment showed that it is aesthetically developing enabling incentives and substantial procedural opportunities for the development of aesthetic culture of police officers and has not only normative, but also ethical and aesthetic properties: meaning-generating and value-oriented context of professional and service (educational) activities, empathic relationships and hermeneutic communication of employees. Based on the situational-environmental approach (N. V. Khodyakova), 4 types of aesthetic-developing situations and the corresponding levels of aesthetic culture of employees are identified: 1) the situation of aesthetic perception (adaptive level); 2) the aesthetic-praxeological situation (selective level); 3) the situation of aesthetic communication and the formation of personal aesthetic assessment (reflexive level); 4) the situation of aesthetic creativity and self-change (creative level). Situational and environmental design is defined as the selection and combination of components of the professional and service environment (incentives and opportunities for the development of aesthetic culture), corresponding to the progressive change in the types of aesthetically developing situations. A consistent change in the type of situation determines the dynamic model of the process of developing the aesthetic culture of the Department of Internal Affairs employees. In accordance with the structural model of the aesthetic culture of the officials and the dynamic model of the process of its formation is defined five groups of criteria and indicators to differentiate officers at different levels of development of aesthetic culture. The process of development of aesthetic culture of police officers during the formative experiment was designed in the form of sequential development officers of educational situations. The study was conducted using a questionnaire (the author's questionnaire), testing (the test "Value orientations" M.Rokich), the method of expert assessments. The data obtained as a result of the study confirm the model of situational and environmental development of the aesthetic culture of police officers.
Information space as a factor in the socio-psychological adaptation of a first grader
Authors: Kopovoy Andrey , Kopovaya Oksana , Erofeeva Mariya
Published: March 2021

The purpose of the research presented in the article is to study the features of socio-psychological adaptation of first-graders with varying degrees of involvement in media consumption. Presumably, this or that level of socio-psychological adaptation of a first-grader corresponds to a certain level of involvement in media consumption (the level of socio-psychological adaptation is inversely proportional to the level of involvement in media consumption). The course and results of the study of the specifics of the socio-psychological adaptation of first-graders and the influence of their involvement in the modern information space on this process are shown. The child’s arrival in the first grade is considered as the most important period of socialization, which largely determines the success of the development of the educational program. The study compares the level of socio-psychological adaptation and the degree of involvement of first-graders in the information space. The results of a survey of parents are presented to determine the degree of involvement of their children in the media. The study involved 76 first-graders and 109 parents (legal representatives). In the course of the study, the following methods were used: methods for express diagnostics of the intellectual development of children 6-7 years old; MEDIS; methodology E.M. Borisova, T.D. Abdurasulova “Choose what you like”; Toulouse-Pierre test; technique "Mittens"; Technique “Graphic dictation” DB Elkonin; questionnaire for parents (legal representatives). The results of the study are the basis for the development of programs for psychological and pedagogical support of the process of socio-psychological adaptation of first graders, taking into account the risk of the influence of modern information space on it.
Correcting ray distortion in tomographic additive manufacturing
Authors: Orth Antony , Sampson Kathleen L. , Ting Kayley , Boisvert Jonathan , Paquet Chantal
Published: March 2021

Light-based additive manufacturing techniques enable a rapid transition from object design to production. In these approaches, a 3D object is typically built by successive polymerization of 2D layers in a photocurable resin. A recently demonstrated technique, however, uses tomographic dose patterning to establish a 3D light dose distribution within a cylindrical glass vial of photoresin. Lensing distortion from the cylindrical vial is currently mitigated by either an index matching bath around the print volume or a cylindrical lens. In this work, we show that these hardware approaches to distortion correction are unnecessary. Instead, we demonstrate how the lensing effect can be computationally corrected by resampling the parallel-beam radon transform into an aberrated geometry. We also demonstrate a more general application of our computational approach by correcting for non-telecentricity inherent in most optical projection systems. We expect that our results will underpin a more simple and flexible class of tomographic 3D printers where deviations from the assumed parallel-beam projection geometry are rectified computationally.
Формирование базы данных о крупных курганах в южной части Обь-Иртышского междуречья
Authors:   Алтайский государственный университет, А.А. Тишкин , Я.В. Фролов ,   Алтайский государственный университет
Published: March 2021

В процессе реализации проекта, поддержанного РФФИ и Администрацией Алтайского края, обозначилась задача аккумулировать сведения о крупных курганах южной части Обь-Иртышского междуречья в базу данных, которая позволяла бы быстро осуществлять поиск необходимой информации о конкретном объекте, а также использовать ее при решении различных научно-исследовательских задач и для реализации экскурсионно-туристической деятельности. Такая работа основывалась на опубликованных и архивных материалах. Она стимулировала проведение дополнительных археологических обследований и осуществление геофизических изысканий. В результате обозначились два подхода к оформлению и наполнению базы данных. Один из них основывался на охвате значительного количества показателей, которые сложно было системно организовать и наглядно продемонстрировать. Второй подход отражал меньший набор признаков, что позволяло сделать оптимальное оформление. Этот вариант и был направлен в ФИПС РФ. В настоящее время получено свидетельство о регистрации базы данных, планируется уточнение зафиксированных сведений и дальнейшее наполнение новой информацией.
Результаты радиоуглеродного датирования кургана №15 из могильника Ханкаринский дол (Северо-Западный Алтай)
Authors:   Алтайский государственный университет, П.К. Дашковский
Published: March 2021

В данной статье представлены результаты радиоуглеродного датирования кургана №15 могильника Ханкаринский дол, входящего в состав Чинетинского археологического микрорайона в Северо-Западном Алтае (Краснощековский район Алтайского края). Курган №15 располагался в центральной части некрополя Ханкаринский дол, большая часть обьектов которого относится к пазырыкской культуре. Для установления датировки кургана №15 могильника Ханкаринский дол проводился радиоуглеродный анализ, который осуществлялся в Аналитическом центре изотопных исследований Института мониторинга климатических и экологических систем Сибирского отделения РАН (г. Томск). В результате получен показатель 2213±76 (ИМКЭС-14С1170). Интервалы калиброванного календарного возраста получены с помощью программы, разработанной в Оксфордском университете (Великобритания). В результате были получены такие данные: 68,% (1 sigma) cal 380–190 ВС и 95% (2 sigma) cal 400–50 BC. Результаты радиоуглеродного датирования были сопоставлены с датировкой, полученной на основе анализа артефактов. Это позволило снивелировать диапазон радиоуглеродных дат и датировать курган №15 могильника Ханкаринский дол IV–III вв. до н.э., вероятнее IV в. до н.э.
Керамика городища Курлак предгорной зоны Алтая (результаты технико-технологического анализа)
Authors:   Алтайский государственный университет, А.А. Казаков ,   Барнаульский юридический институт МВД России, Н.Ф. Степанова ,   Институт археологии и этнографии СО РАН
Published: March 2021

В статье приводится характеристика керамики майминской культуры городища Курлак из северных предгорий Алтая. Отмечено большое разнообразие оформления венчиков и днищ сосудов, выделено пять групп керамики по орнаменту. Технико-технологический анализ выявил, что наиболее распространенным является рецепт глина+дресва+органика, как исключение встречаются рецепты глина+шамот+органика и глина ожелезненная+глина неожелезненная+дресва+органика, а исходное сырье брали преимущественно из похожих источников. Это отличает керамику Курлака от других памятников майминской культуры – Новозыково-3, Майма-1. Для них характерно большое разнообразие рецептов формовочных масс и источников исходного сырья, отмечены контакты населения с разными культурными традициями. Возможно, выявленные особенности керамического комплекса с городища Курлак связаны с тем, что оно может относиться к наиболее ранней группе памятников майминской культуры, население которого еще не подверглась смешению культурных традиций.
Продукты первичного расщепления и орудия на пластинах поселения Пестряково Озеро (юг Западной Сибири)
Authors:   Алтайский государственный университет, К.Ю. Кирюшин , Ю.Ф. Кирюшин ,   Altai State University
Published: March 2021

Коллекция каменных артефактов с поселения Пестряково Озеро насчитывает 2880 экз., из них продукты первичного расщепления – 32 экз., орудийный набор – 578 экз., отходы производства – 2259 экз. В рассматриваемой коллекции продукты первичного расщепления составляют всего 1,46% от всех каменных артефактов. В статье выдвигается предположение, что первичное расщепление происходило вне пределов памятника, а на поселение Пестряково Озеро в основном поступали уже готовые изделия и орудия. В процессе использования орудия срабатывались, и их приходилось периодически подновлять, в результате чего в основном получались чешуйки и мелкие отщепы, которые составляют более половины всех артефактов в коллекции. Сломанные орудия, крупные и средние отщепы являлись вторичной сырьевой базой и использовались в качестве материала для изготовления более мелких орудий другого назначения. В материалах исследуемого памятника прослеживаются тенденции, характерные для поселенческих комплексов неолита Алтая, удаленных от источников сырья.
К вопросу о культурно-исторических процессах в неолите Северо-Восточного Казахстана и сопредельных регионов
Authors:   Центр археологических исследований Торайгыров университет, В.К. Мерц
Published: March 2021

В статье рассматриваются результаты изучения неолита Северо-Восточного Казахстана и культурно-исторических процессов, которые происходили в регионе в указанный период. Они свидетельствуют о том, что там была контактная зона нескольких культурных образований, представленных разными типами керамики, но базировавшихся на общих сырьевых источниках и имевших сходные типы индустрий. Их формирование было связано с периодической сменой технологических приемов обработки камня с предпочтением того или иного вида сырья, являющегося культурно-хронологическим маркером, связанным с приходом с Юго-Запада и Запада новых групп населения, возможно, имевших навыки производящего хозяйства в виде пастушеского скотоводства. Однако следы скотоводства фиксируются лишь в позднем неолите на поселении Борлы, в слое с керамикой боборыкинского типа, также имеющей, по мнению некоторых исследователей, юго-западное происхождение.