bluuebunny/crossref_metadata_2025 huggingface dataset:
Diversity and Similarity Gomphocerinae (Orthoptera: Acrididae) Communities in the Brazilian Amazon
Authors: Santos Junior Walmyr Alberto Costa , Martins Christiane França , Souto Raimundo Nonato Picanço
Published: July 2021

Inventories of Amazon invertebrates are relatively incipient and fragmented. The state of Amapá is one of the Amazonian states with a large knowledge gap regarding invertebrate biodiversity. Also, there is no record in the literature of systematic studies that focus mainly on the Acridofauna. Therefore the goal of this study was to understand the diversity and abundance of grasshoppers (Gomphocerinae) of the Environmental Protection Area of the Curiaú river, Macapá - AP. Twelve samples were collected from October 2011 to September 2012 using the active search technique with sweep nets. A total of 508 Gomphocerinae individuals were sampled and classified into five genera and twelve species. The floristic composition of sites A1 and A3, and sites A5 and A6, are considered more similar since the locusts are closely related to the vegetation. This is the first study assessing the diversity of orthopteroides in the state of Amapá. However, this pioneering study is expected to be the basis of future studies.
Distúrbios endocrinológicos na Distrofia Muscular de Duchenne: Um relato de caso
Authors: Bonilha Gabriela Sacuno , Ranzan Isabel Cristina , Pescador Marise Vilas Boas
Published: July 2021

A Distrofia Muscular de Duchenne (DMD) é uma doença hereditária, autossômica recessiva ligada ao X, acometendo, principalmente, o sexo masculino. Há o comprometimento muscular progressivo, começando pelos músculos proximais dos membros inferiores, depois ocorre redução da força muscular dos membros superiores e comprometimento dos músculos cardíacos e respiratórios, não existindo terapia curativa. Dessa forma, este trabalho tem como objetivo relatar um caso de um paciente com distrofia muscular de Duchenne, enfatizando os possíveis efeitos endocrinológicos que podem manifestar-se nessa patologia. A melhor medicação para o manejo da doença é o corticosteroide, o qual melhora a força muscular, prologando o tempo de marcha, preservando a função dos membros superiores, prevenindo escoliose, reduzindo progressão da cardiomiopatia e atrasando a necessidade de ventilação invasiva.  No entanto, essa medicação oferece uma gama de efeitos adversos a esses pacientes, se fazendo necessário o atendimento endocrinológico, com os seguintes objetivos: monitorar o crescimento, desenvolvimento puberal, diagnosticar deficiências hormonais, fornecendo terapia de reposição quando necessário e prevenindo a ocorrência de crise adrenal.
Diagrama Entidade-Relacionamento: uma ferramenta para modelagem de dados conceituais em Engenharia de Software
Authors: Franck Kewry Mariobo , Pereira Robson Fernandes , Dantas Filho Jerônimo Vieira
Published: July 2021

A modelagem de dados é o principal componente de informações conceituais do banco de dados, dentre as técnicas para essa modelagem, a entidade-relacionamento (ER) é abordada nesse trabalho. O objetivo do estudo é abordar as principais informações sobre o modelo entidade-relacionamento como ferramenta para modelagem de dados conceituais. O Modelo Entidade-Relacionamento, e principalmente o diagrama, é uma importante ferramenta durante o desenvolvimento de sistemas, principalmente aqueles mais complexos e difíceis de visualizar sem uma análise mais aprofundada. Além disso, é um modelo conceitual utilizado na Engenharia de Software para descrever as entidades envolvidas em um domínio de negócios, com seus atributos e como elas se relacionam entre si. De modo geral, representa de forma abstrata a estrutura que possuirá o banco de dados da aplicação. O banco de dados poderá conter várias outras entidades, tais como chaves e tabelas intermediárias, que podem fazer sentido no contexto de bases de dados relacionais.
The influence of ball possession, passes and shots on target in winning premier league football matches
Authors: Rocha-Lima Eric  Matheus , Tertuliano Ivan Wallan , Fischer Carlos Norberto
Published: July 2021

Football is the most popular sport in the world and involves the availability of information of footballers and teams to investigate success in this sport. In account of these aspects, the current study aims to analyze the influence of ball possession time, passes and shots on target in winning Premier League football matches. The methodology adopted consists of a quantitative, descriptive and documentary research, in which the sample is represented by all the 380 Premier League (PL) matches of the 2015/2016 season. The analysis process was made by the use of the association technique, present in the data mining process, with the support of the Weka software. The results suggest that shots on target, as well as its interaction with ball possession and passes - total passes, accuracy of passes, accuracy of passes inside the opponent’s field and long passes - influenced the final result of the match. Based on the results, the conclusion is that direct play alternatives, such as presenting less ball possession time and more long passes, associated with more shots on target, showed to be more beneficial for football clubs to win football matches.
Características individuais e alimentares de indivíduos em tratamento quimioterápico para neoplasias gastrointestinais: Um estudo transversal
Authors: Coelho Julita Maria Freitas , Araújo Tamires Pastor de , Lima Sophia dos Santos , Lima Larissa Silva , Silva Michele Bastos da , Araujo Lucas Souza Almeida de , Leite Érica Brasil , Barros Sarah Souza , Silva Roberta Borges , Conceição Sarah dos Santos , Silva Maria Emília Cirqueira , Pereira Fernanda Rodrigues Brandão , Mercês Magno Conceição das , Silva Jalyne Malheiro da
Published: July 2021

Objetivo: Investigar as características individuais e alimentares em indivíduos em tratamento quimioterápico de câncer do trato gastrointestinal (TGI) atendidos em uma Unidade de Alta Complexidade em Oncologia. Método: Estudo transversal, quantitativo, descritivo e exploratório, a partir de dados secundários de um estudo prévio que usou um questionário próprio e informações de prontuários médicos e o teste “Como está sua Alimentação?” do Ministério da Saúde do Brasil. Foram obtidas frequências absolutas e relativas e o p-valor de todas as variáveis incluídas. Resultados: Foram observados 22 participantes com câncer do TGI, sendo que a maioria tinha raça/cor autorreferida como preta ou parda, sexo feminino, com companheiro, com até dois filhos, menor densidade domiciliar, menor escolaridade e sem ocupação. Observou-se maior consumo de frutas e leguminosas, baixo consumo de hortaliças, carne, laticínios e carboidratos em geral, além de alto consumo de doces e gorduras. A prática de atividade física foi pouco frequente e o etilismo frequente na amostra estudada. Os participantes relataram boa qualidade da alimentação, e referiram predominantemente realizarem quatro ou mais refeições ao dia. Considerações Finais: Resultados apontam o alto consumo de alimentos de alto teor energético e pouco nutritivos, como gorduras e doces, além de reduzidas proporções de alimentos reguladores. Faz-se necessária, adequada intervenção nutricional nesses indivíduos durante e após o tratamento quimioterápico. Em síntese, ressalta-se o papel de um perfil alimentar inadequado, o qual associado a um estilo de vida sedentário configura um fator de risco para doenças crônicas como o câncer.
Política, Biossegurança, Jogos Olímpicos e Paralímpicos Tóquio 2020
Authors: Dantas Matheus Jancy Bezerra , Dantas Thaísa Lucas Filgueira Souza , Souza Samia Rayra Silva de Azevedo , Oliveira José Igor Vasconcelos de , Oliveira Saulo Fernandes Melo de
Published: July 2021

As Olimpíadas e as Paralimpíadas são bem esperados por todos. É simplesmente o maior evento esportivo do mundo, que reúne milhares de atletas de centenas de países diferentes e foi completamente atingido pela Pandemia da COVID-19. Ninguém contava que ações biológicas, SARS-CoV-2, poderiam modificar todo o cenário esportivo mundial. Dessa maneira, o estudo se propôs discutir sobre política, biossegurança e a realização dos Jogos Olímpicos e Paralímpicos. Apesar das campanhas de vacinação o mundo ainda não está livre da pandemia da COVID-19. Tóquio encontra-se em estado de emergência atualmente em vigor. Ao final dos Jogos, o que será mais impactante, o maior acesso à vacinação pelos países ricos, que devem deter o maior número de medalhas, ou as intervenções políticas por instituições que têm interesses comerciais em Tóquio 2020?
Cognição na doença de Chagas: Uma revisão sistemática
Authors: Santos Natalia Ligabô dos , Reis Laysa Rodrigues dos , Rodrigues Felipe Viegas
Published: July 2021

A doença de Chagas (DC) é transmitida pelo parasita hemoflagelado Trypanosoma cruzi e manifesta-se inicialmente de forma aguda e, depois, permanece na forma crônica, quando é caracterizada como indeterminada, cardíaca, digestiva ou mista. Alguns pacientes com doença de Chagas (DC) apresentam alterações cognitivas e há três hipóteses sobre os danos cognitivos: (I) alterações neurológicas e cognitivas causadas por consequência da forma cardíaca, (II) após a forma aguda há o desaparecimento espontâneo dos sinais clínicos da doença permanecendo as manifestações cognitivas, (III) as manifestações cognitivas e neurológicas são causadas por infecção crônica. O objetivo do presente trabalho foi fazer uma revisão sistemática da literatura para verificar os prejuízos cognitivos mensuráveis em pacientes chagásicos. Os artigos foram pesquisados nas bases Pubmed e Embase, com os descritores “Chagas disease” e “cognition”. Foram incluídos artigos com mensuração de aspectos cognitivos de pacientes com a DC. Foram encontrados cento e noventa e sete artigos, três dos quais atendiam aos critérios. Todos os artigos demonstram prejuízos cognitivos relacionados à DC, forma crônica, com comprometimento tanto da inteligência geral quanto da memória de longa-duração, além de déficit no tempo de execução dos testes.
Proteinograma do leite de vacas com mastite subclínica em função do escore de células somáticas
Authors: Alves Fernanda Antunha de Freitas , Sola Marilia Cristina , Mesquita Albenones José
Published: July 2021

Objetivou-se, com o presente estudo, investigar a influência do aumento da CCS na expressão das proteínas do soro de leite por meio da utilização da técnica de separação de proteínas de eletroforese microfluídica em microchip (lab-on-a-chip). Foram coletadas 104 amostras de leite de vacas em duas propriedades localizadas no Estado de Goiás. As amostras foram analisadas quanto a contagem de células somáticas e eletroforese microfluídica lab-on-a-chip. Para o teste de correlação entre o perfil de proteínas e a CCS foram utilizadas 50 amostras de leite e estas foram estratificadas em cinco grupos de escores de células somáticas, sendo utilizado um delineamento inteiramente ao acaso com cinco tratamentos, avaliado por meio da estatística descritiva e representações gráficas. Verificou-se um aumento significativo no valor do componente proteína em relação aos ECS 1 e 3, 1 e 4 e 1 e 5. Também foi possível observar diferença estatística nos resultados do componente Lactose quando se comparou os ECS 1 e 3 e 3 e 4. Na avaliação descritiva da variável “Concentração” das proteínas do leite foi possível observar diferenças nos valores das concentrações em função do ECS. Foi possível observar diferença estatística para os resultados obtidos para as proteínas α-LA, quando comparados os ECS 1, 2 e 3 e o ECS 5; para a IgG, as amostras de ECS 4 e 5 apresentaram concentrações diferentes das amostras dos ECS 1, 2 e 3; e a proteína LF, apresentou resultados diferentes entre as amostras de ECS 1 e 5. Concluiu-se que proteínas de alta abundância do soro de leite tem sua concentração diminuída em função da severidade da mastite; proteínas de defesa, como Lactoferrina, Lactoperoxidase e IgG e IgM têm aumento em suas concentrações quando se comparam amostras de leite de vacas com mastite subclínica e amostras de leite de vacas sadias; as proteínas Lactoferrina e IgG constituem alvos em potencial para identificar vacas com mastite subclínica a partir de amostras de leite, podendo ser consideradas biomarcadores.
Класифікація строків у процедурі банкрутства
Authors: БУТИРСЬКИЙ АНДРІЙ
Published: July 2021

Процедура банкрутства є необхідним елементом ринкової економіки, який у підсумку забезпечує задоволення вимог кредиторів та відновлення платоспроможності боржника, що відбувається завдяки спеціальному механізму, який функціонує на підставі Кодексу України з процедур банкрутства (КУзПБ). Для отримання зазначених результатів учасникам справи про банкрутство доводиться пройти тривалий шлях: від відкриття провадження у справі до досягнення необхідного результату (отримання коштів кредиторами, затвердження звіту ліквідатора або керуючого санацією тощо). У цьому контексті варто звернути увагу саме на тривалість процедури банкрутства, оскільки грошові кошти мають схильність до знецінення, що зумовлено інфляційними процесами у державі, або подекуди самі кредитори стають боржниками через нескінченно довгу процедуру банкрутства і неможливість отримати свої кошти.
Метою статті є розроблення авторської класифікації строків у процедурі банкрутства.
В основі справи про банкрутство завжди лежить матеріально-правовий інтерес учасників цієї процедури, задоволення якого здійснюється у межах судових процедур банкрутства, на підставі процесуальних норм КУзПБ і Господарського процесуального кодексу України.
За результатами дослідження автор доходить висновку, що зважаючи на комплекс ний характер такої підгалузі господарського права, як банкрутство, у цій процедурі знаходить свій прояв велика кількість строків, що зумовлює необхідність їхньої класифікації за декількома критеріями.
Строки у процедурі банкрутства пропонуємо класифікувати за такими критеріями: видом законодавства, яке регламентує такі строки (строки, передбачені загальним законодавством, і строки, передбачені спеціальним законодавством); характером правовідносин, у яких застосовуються строки у процедурі банкрутства (матеріальні, процедурні та процесуальні); залежно від наслідків застосування (загальні строки та присікальні строки у процедурі банкрутства).
Чотири вершники трансформацій: ефективність правового регулювання економічних інституцій
Authors: САВЧИН МИХАЙЛО
Published: July 2021

У перехідних конституційних демократіях проблема ефективності правового регулювання економічних інститутів зумовлена трансформаційними процесами в політичній, економічній, соціальній та культурній сферах. Особливо гострою є взаємодія політичних та економічних факторів у функціонуванні економічних інститутів, оскільки це методологічна проблема реалізації реформ. У статті розглядається це питання крізь призму верховенства права, належного урядування та принципів пропорційності втручання в економічні свободи з метою забезпечення економічного добробуту. Це досить абстрактне формулювання питання потребує його аналізу через призму трансформації сучасної економічної системи та переосмислення функцій держави. Метою статті є визначення основних параметрів ефективності правового регулювання економічних інститутів. Доведено, що система гарантій економічних свобод базується на конституційних цінностях, які виражають консенсус щодо цільових установок учасників економічних відносин, їх цілепокладання. Ключовими факторами цього процесу є трансформація глобалізації та регіональне економічне співробітництво між державами, що змінює їхні функції. Зближення держави та приватного сектору виражається у диджиталізації економіки та зростанні ролі штучного інтелекту в економічних процесах, що дедалі більше впливає на зміст правил і процедур на ринку. Оскільки за таких умов змінюється структура професій та зайнятості, це призводить до розширення сфери інтелектуальної діяльності людства. Ключовим фактором трансформації українського конституціоналізму є відмова від постколоніальних практик управління через відносини ієрархії. Їх змінюють відносини гетерархії, які поєднують субординацію та горизонтальні зв’язки в економічній системі. Порядок визнання норм за допомогою поєднання приватного права та публічного механізму правотворення є на порядку денному. Аналогічним чином успіх економічних реформ обумовлений існуванням незалежних інституцій, що важко уявити без політико-правової складової. До таких інструментів належать судовий контроль за конституцією, неупереджене та незалежне публічне урядування, зокрема у діяльності незалежних державних установ, які рівновіддалені від політичних інститутів і ділових кіл. Економічні структури повинні брати участь у збереженні довкілля, впровадженні новітньої структури охорони здоров’я та наданні доступних і якісних адміністративних послуг населенню. Тому цінності та настанови щодо конкурентоспроможності, належної ділової практики на ринку забезпечуються інструментами економічного конституціоналізму, регуляторної держави та демократичної підзвітності. Засобами забезпечення цього є верховенство права, незалежні державні регулятори й вимоги щодо прозорості та належної процедури при ухваленні владних рішень.
Природа податку як конструкції зустрічного узгодження обов’язків (на прикладі підприємств критичної інфраструктури)
Authors: КУЧЕРЯВЕНКО МИКОЛА
Published: July 2021

Сьогодні особливої актуальності набувають питання, пов’язані з узгодженням зустрічних обов’язків на рівні “держава – платник податків”.
Мета статті полягає у визначенні конструкції зустрічного узгодження обов’язків держави та платника податків на прикладі функціонування правового механізму податку на додану вартість у контексті діяльності підприємств критичної інфраструктури.
Констатовано, що традиційний погляд на характеристику природи податкових відносин через акцент виключно на регулювання та гарантування своєчасного виконання обов’язків платника податку виглядає дещо спрощеним. Загальну конструкцію упорядкування поведінки учасників податкових відносин треба коригувати залежно як від типу платника, так і від характеру складової податкового обов’язку в широкому сенсі.
Зазначено, що не можна характеризувати податок лише в контексті системності імперативних обов’язків щодо регулювання поведінки зобов’язаної особи. Цілісна конструкція податку передбачає і мету акумуляції коштів публічного суб’єкта через надходження коштів від сплати податків. Умовність податкового платежу передбачає і виконання обов’язку з боку держави та територіальних громад. Тобто податок – це кошти, які в імперативному режимі передає платник державі чи територіальній громаді з обов’язковою умовою витрачання їх на загально-суспільні цілі та потреби.
The impact of a pandemic on the development of logistics: EU experience and problems in Ukraine
Authors: Kuzmenko Olena , Kuzmenko Valentyn , Kukhtina Viktoriya
Published: July 2021

An important aspect of any industry is the rapid and effective adaptation to changing conditions. The logistics market during the pandemic and related constraints has changed significantly, and competition in this segment has become higher than ever. Many consumers are forced to reduce consumption, companies have reduced supplies and production, diversified their activities. The transportation market has become denser and the struggle for the customer has intensified. Optimization of financial, labor, and material resources through the reduction of activities can negatively affect the quality of logistics services, the speed of processing goods, and their delivery to the final consumer. Based on the relevance, the aim of the research is to study the impact of the COVID-19 pandemic on logistics, assess the results of such impacts in the EU, as well as outline trends and prospects for the logistics market in terms of declining coronavirus and market recovery. The research methodology is based on the use of general scientific and specific methods, in particular: analysis and synthesis, induction and deduction, systematization, generalization. The scientific novelty of the study is that the changes that have taken place in logistics have led to the emergence of new trends and trends that need to be generalized and evaluated in terms of prospects for impact on the industry. The study summarized the conclusion that the coronavirus pandemic created opportunities for some companies and threats for others. As a result of the constraints and challenges that have become inherent in international business and logistics, e-commerce, on-demand delivery, and the concept of “last kilometers” are developing rapidly in the EU and Ukraine. The logistics market has a tendency to consolidate and diversify. At the same time, once the European economy returns to normal, most of the changes that have taken place in logistics will be irreversible.
Keywords: logistics, pandemic consequences, trade, supply chain, transport
Innovative and investment approaches to economic development of green tourism in rural areas in the context of decentralization
Authors: Vdovenko Nataliia , Korobova Nataliia , Nevesenko Anna
Published: July 2021

The purpose of the article is to substantiate the innovation and investment principles of green tourism in rural areas in the context of decentralization with a combination of production systems in order to explore opportunities and provide proposals for further functioning of the national economy. Methodology research is to use a set of methods: economic-statistical, monographic, system, economic- mathematical, abstract-logical and others. The scientific novelty of the obtained results is the introduction of innovative, economically feasible and research meth- ods with regard to sustainable development of green tourism in rural areas in decentralization, which are associated with the adaptation of theories, principles and rules of great importance for sustainable rural development of green tourism in the context of global transformations. Conclusions. The modern principles of effective functioning of green tourism in rural areas in the conditions of decen- tralization at a combination of production systems are substantiated. The tools of the general research methodology with regard to sustainable development of green tourism in rural areas in the context of decentralization are proposed. Adaptation of a system of theories, principles and rules that are essential for the formation of sustainable rural development are related.
Key words: rural areas, decentralization, green tourism, innovations, branch, sustainable development, aquaculture, tools, methods.
The current issues of using innovative solutions in waste-free management systems
Authors: Vytvytska Olga , Pundyk Mykyt
Published: July 2021

The purpose of the article. The purpose of the study is to substantiate the theoretical foundations and practical innovative solutions for the reuse of waste resources with a proposal for improved waste management technology with prospects for implementation in Ukraine.
Research methodology: theoretical and practical aspects of the introduction and implementation of eco-management, because for Ukraine such an approach to the introduction of innovative processing technologies in enterprises is completely new. Methodical toolkit of substantiation of innovative decisions of reuse of resources from waste, structure of prime cost of the improved system for the Goloseevsky area. Kiev.
Scientific novelty. It is proposed to optimize the existing garbage problem in most regions and replace waste trucks based on the method of the pneumatic system manufactured by Envac. The system allows you to reduce the cost of moving cargo over time sorting or disposal points.
Conclusions. The introduction of innovative systems in Ukraine for the year saves UAH 34 billion 499 million, in addition, the sorting of household waste is gaining popularity, recycling tanks are being installed in cities, the population is beginning to treat waste with understanding, and a behavioral strategy has been introduced to stimulate waste recycling. In addition, the proposed technology of sorting raw materials allows you to sort up to 97% of household waste, and the rest to burn for energy. All this makes the development of the processing industry in Ukraine promising.
Keywords: innovations, waste-free systems, secondary raw materials, energy, technology.
Market development of the economy of the eu and Ukraine: asymmetry and ways of overcoming it
Authors: Redzyuk Yevhen
Published: July 2021

The goal of this article is to develop practical, scientific and methodological recommendations to improve the market development of Ukraine and reduce the divergence of its economy in relation to the EU economy. Research methodology includes: system-structural and comparative studies (to understand the logic of the functioning of modern market institutions in Ukraine and Europe); monographic analysis (in the study of approaches to improve the market development of the Ukrainian economy); statistical and economic analysis (when carrying out a rating assessment in relation to economic freedoms and competitiveness of the Ukrainian economy). Scientific novelty: it was revealed that the state of market development of the Ukrainian economy is significantly lower not only in comparison with the EU countries, many CIS countries, but also lags behind the overwhelming major- ity of countries in the world. The reason for this is the low efficiency of the ju- dicial and law enforcement system; weakness and archaism of state regulation of the business environment; monopolization and oligarchization of the economy, non-transparent approaches to the privatization of assets in Ukraine; “Black” and “gray” land market; violation of customs procedures and registrations, which sig- nificantly saturate the markets of Ukraine with counterfeit and smuggled goods. In contrast, EU countries are pursuing policies that promote asset and property rights protection, stimulate job creation and economic growth by creating a busi- ness-friendly climate, as well as focusing on innovation and related infrastructure aid funds. Conclusions: a proactive state policy is needed in the formation of ef- fective regulatory institutions in Ukraine, in anti-corruption and economic reforms, in reducing the level of monopolization and oligarchization of markets; also priva- tization stimulating investment and innovation; transition from extensive to in- tensive management methods; embedding of domestic products into external value chains; increasing investment in domestic infrastructure; priority in the develop- ment of small and medium-sized businesses; systemic focus on increasing the productivity of the economy; the emergence of new businesses in a low-carbon and environmentally friendly economy.
Key words: economies of the EU and Ukraine, market development, European economic integration, world economy.
The importance of social business in the context of stable development of Ukraine's economy
Authors: Bilanych Lyudmyla , Kulesha-Liubinets Myroslava , Kulinich Tetiana
Published: July 2021

Abstract. Nowadays the most characteristic are intense and rapid globalization, European integration processes, international social and economic cooperation and, in addition, popularization of new ideas about democracy, professional honesty, social and environmental responsibility and governance in entrepreneurship. Taken together, these factors are complementary and can advance for sustainable development of Ukraine. In this context sustainable economic development is symbiosis of an effective commercial and social business. The achievement of the optimum balance between profit maximization of Ukrainians’ companies in a long run and meeting the population’s socio-economic needs, such as enhancement of the quality of life is now recognized as a major challenge for our country. This situation is particularly complicated by the case of permanent complex crises and unsuccessful reformation of national public government.
The article is devoted to the analysis of considerable theoretical and practical significance of social business as a primary entrepreneurship by which sustainable economic development of Ukraine is achieved. Social business is essential to strengthen the social responsibility, social awareness and civil unity among the market participants. These issues have been outlined in this science paper by authors.
Comparison, methods of abstraction, analysis and generalization, graphic and tabular modeling are the research methods which were used in the article.
In this science paper the concept of “social business”, the main features, basic principles and functions of the social entrepreneurship and impacts of the social business sector on sustainable economic development of Ukraine are analyzed by authors.
So, based on theoretical and methodological research, it was determined that sustainable development is our country’s strategic goal. In the meantime, social business development is one of the key vectors to achieve defined objective.
Key words: Sustainable development goals of Ukraine, social business, social entrepreneurship, incentives for development of social business in Ukraine.
Optimal Education Plan of Employees Using Maintenance Model
Authors: Yamashita Shigeshi , Ito Kodo , Kawakami Sho , Khoa Truong Dinh Anh
Published: July 2021

The employee education is indispensable for companies to improve productive efficiency and product quality. In general, the employee education is divided into two types, i.e., On-job trainings and Off-job ones, and Off-job trainings are divided into two types, i.e., compulsory educations and non-compulsory ones. Compulsory educations such as safety program and compliance education, are necessary to maintain daily production without any accidents. Although all employees of a department and a division gather in a classroom annually in conventional compulsory educations, daily e-learning education complements and strengthens conventional compulsory ones today because employees forget what they learn by annual learning. In past studies, the logit model is used for modeling the influence from education receipt to its memory condition and quantitative relationship between the effect of traffic safety education and the accident-related human-errors was clarified. The effectiveness of the safety driving educational program was indicated by Structural Equation Modelling method. In this paper, an annual compulsory which is complemented and strengthened by e-learning, is discussed. The expected cost rate of education is expressed using imperfect maintenance models and optimal policies which minimizes it is considered. Although we use the exponential function which denotes the occurrence probability of accidents which are caused by forgetting lessons, the actual occurrence probability which is approximated from the actual data would be a complicated one. For solving such complex optimization problems, metaheuristic methods can be applied.
Application of Software Reliability Model for Safety Assessment of E/E/PE Safety-Related Software
Authors: Inoue Shinji , Fujiwara Takaji , Yamada Shigeru
Published: July 2021

Quantitative and analytical safety assessment methods of E/E/PE safety-related software systems based on the SIL defined by IEC 61508 have been proposed. IEC 61508 does not provide us with quantitative and analytical methods for safety assessment of the software. Our methods give us quantitative information on safety measures for deciding the safety integrity level and testing time duration for achieving certain safety integrity level of E/E/PE software, respectively. Our stochastic modeling approaches are based on software reliability modeling and software reliability assessment techniques. Numerical examples for our methods have been shown for explaining how to use our software safety assessment approaches conforming IEC 61508.
Multi-Objective Faculty Course Assignment Problem with Result and Feedback Based Uncertain Preferences
Authors: Bhoi Sunil B. , Dhodiya Jayesh M
Published: July 2021

In this paper, a multi-objective faculty course allocation problem with result analysis and feedback analysis based on uncertain preferences mathematical model is presented. To deal with an uncertain model, three different ranking criteria are being used to develop: a) Expected value, b) Optimistic value, c) Dependent optimistic value criterion. These mathematical models are transformed into their corresponding deterministic forms using the basic concepts of uncertainty theory. The deterministic model of DOCM consists of fractional objectives which are converted into their linear form using Charnes and Cooper’s transformation. These deterministic formulations MOFCAP are converted into a single objective problem by using the fuzzy programming technique with linear and exponential membership functions. Further, the single objective problem for all the defined models is solved in the Lingo 18.0 software to derive the Pareto-optimal solution. The sensitivity of the models is also performed to examine the variation in the objective function due to the variation in parameters. Finally, a numerical example is given to exhibit the application and algorithm of the models.
Study of Factors Influence on the Variability of Time for Consensus Building in Coalitions Based on Regular Markov Chains
Authors: Maksimova Olga V. , Aronov Iosif Z.
Published: July 2021

Draft standard is approved if and only if consensus of the technical committee for standardization (TC) is ensured before its approval by the standardization body at the national, regional and international level. Previously published works of authors dedicated to the construction of a mathematical model of time to build a consensus (number of negotiations) in terms of variation in the number of TC members and their level of authoritarianism. The present study is a continuation of these works for the case of the formation of coalitions in TC. The mathematical model is constructed to ensure consensus on the work of technical standardization committees in terms of coalitions, which are overcome during the negotiation process by concessions. This paper analyzes the factors, which influence the time for consensus building in this case: the value of the assignment and an index of the effect of the coalition. It is proved that the time to build a consensus signifi-cantly depends on the value of unilateral concessions coalition and weakly depends on the size of coalitions with a fixed number of TC members. Built regression model of dependence of the average number of approvals from the value of the assignment. It was revealed that even a small concession leads to the onset of consensus, increasing the size of the as-signment results (with other factors being equal) to a sharp decline in time before the consensus. It is shown that the as-signment of a larger coalition against small coalitions takes on average more time before building a consensus.

The factors influencing the variability of the number of concessions were investigated. The change in the root-mean-square deviation (RMS) of the time to build a consensus varies nonlinearly from small concessions Y=10% to large Y=75%, regardless of the ratio of the number of members between coalitions. In the simulations, at concessions Y=10% there is the largest variation among the number of consensuses in the experiments.

Concession of the authoritarian leader in group reduces the number of negotiations and increases the quality of consensus. The results obtained are of practical value for all structures where the emergence of coalitions entails the impossibility of consensual decision-making and requires consideration of different ways to build a consensual solution.
Two-Dimensional Stress Analysis of Thick Hollow Functionally Graded Sphere Under Non-Axisymmetric Mechanical Loading
Authors: Paul Sandeep Kumar , Sahni Manoj
Published: July 2021

In this paper, a functionally graded thick hollow sphere is considered for the analysis of two-dimensional steady state mechanical stress in the radial and circumferential directions under mechanical loading. Modulus of elasticity is varying with continuous nonlinear variation along the radial direction and Poisson’s ratio is kept as constant. The Legendre series and Euler differential equation are used to solve Navier equations. Geometry of the sphere is assumed in spherical coordinate system. Applying mechanical boundary conditions at inner and outer radii, we have carried out the analytical solutions for stresses, strains and displacements. In the numerical example, only internal pressure is varying along circumferential direction and external pressure is kept as zero. Displacements and mechanical stresses are presented graphically and the results are discussed numerically.
Presentation of Coupling Analysis Techniques of Maximum and Minimum Values Between N Sets of Data Using Matrix [µ][MKN]
Authors: Makris K. N. , Vonta I.
Published: July 2021

This paper deals with the presentation and study of alternative coupling techniques for maximum and minimum values between data sets, namely the problem which is examined in this work is the possible appearance of maximum or minimum values between data sets in the same or neighboring time points. The data can be time-dependent (time series) or non-time-dependent. In this work, the analysis is focused on time series and novel indices are defined in order to measure whether the values of N sets of data display in terms of time, the maximum or minimum values at the same instances or at very close instances. For this purpose, two methods will be compared, one direct method and one indirect method. The indirect method is based on Matrices of dimensionless indicators which are denoted by [μ][MKN], and the direct method is based on a variance-type measure which is denoted by [V][MKN].
The Microtubule Minus-End Binding Protein Patronin Is Required for the Epithelial Remodeling in the Drosophila Abdomen
Authors: Panzade Sadhana , Matis Maja
Published: July 2021

In the developingDrosophilaabdomen, the epithelial tissue displays extensive cytoskeletal remodeling. In stark contrast to the spatio-temporal control of the actin cytoskeleton, the regulation of microtubule architecture during epithelial morphogenesis has remained opaque. In particular, its role in cell motility remains unclear. Here, we show that minus-end binding protein Patronin is required for organizing microtubule arrays in histoblast cells that form theDrosophilaabdomen. Loss of Patronin results in a dorsal cleft, indicating the compromised function of histoblasts. We further show that Patronin is polarized in these cells and is required for the formation of highly dynamic non-centrosomal microtubules in the migrating histoblasts. Thus, our study demonstrates that regulation of microtubule cytoskeleton through Patronin mediates epithelium remodeling.
LINCing Nuclear Mechanobiology With Skeletal Muscle Mass and Function
Authors: van Ingen Maria J. A. , Kirby Tyler J.
Published: July 2021

Skeletal muscle demonstrates a high degree of adaptability in response to changes in mechanical input. The phenotypic transformation in response to mechanical cues includes changes in muscle mass and force generating capabilities, yet the molecular pathways that govern skeletal muscle adaptation are still incompletely understood. While there is strong evidence that mechanotransduction pathways that stimulate protein synthesis play a key role in regulation of muscle mass, there are likely additional mechano-sensitive mechanisms important for controlling functional muscle adaptation. There is emerging evidence that the cell nucleus can directly respond to mechanical signals (i.e., nuclear mechanotransduction), providing a potential additional level of cellular regulation for controlling skeletal muscle mass. The importance of nuclear mechanotransduction in cellular function is evident by the various genetic diseases that arise from mutations in proteins crucial to the transmission of force between the cytoskeleton and the nucleus. Intriguingly, these diseases preferentially affect cardiac and skeletal muscle, suggesting that nuclear mechanotransduction is critically important for striated muscle homeostasis. Here we discuss our current understanding for how the nucleus acts as a mechanosensor, describe the main cytoskeletal and nuclear proteins involved in the process, and propose how similar mechanoresponsive mechanisms could occur in the unique cellular environment of a myofiber. In addition, we examine how nuclear mechanotransduction fits into our current framework for how mechanical stimuli regulates skeletal muscle mass.
A Comprehensive Overview of circRNAs: Emerging Biomarkers and Potential Therapeutics in Gynecological Cancers
Authors: Ma Yalan , Zheng Lianwen , Gao Yiyin , Zhang Wenying , Zhang Qiang , Xu Ying
Published: July 2021

Circular RNA (circRNA) is a highly conserved, stable and abundant non-coding RNA (ncRNA). Also, some circRNAs play an essential part in the progression of human cancers. CircRNA is different from traditional linear RNA. CircRNA has a closed circular structure, so it is resistant to exonuclease-mediated degradation and is more stable than linear RNA. Numerous studies have found that many circRNAs can act as a microRNA (miRNA) sponge, interact with RNA-binding proteins, regulate gene transcription, affect alternative splicing and be translated into proteins. Recently, some studies have also indicated that circRNA participates in the progression of gynecological cancers. In addition, circRNA can act as a promising biomarker for the diagnosis of gynecological tumors. Additionally, they can also play a key role in the prognosis of gynecological tumors. Furthermore, to our delight, circRNA may be a potential therapeutic target in gynecological cancers and widely used in clinical practice. This article reviews the functions and related molecular mechanisms of circRNAs in gynecological tumors, and discusses their potential as biomarkers for diagnostic and prognostic and therapeutic targets for gynecological cancers.
Identification of Somatic Mutation-Driven Immune Cells by Integrating Genomic and Transcriptome Data
Authors: Jiang Ying , Zheng Baotong , Yang Yang , Li Xiangmei , Han Junwei
Published: July 2021

Tumor somatic mutations in protein-coding regions may generate neoantigens which may trigger antitumor immune cell response. Increasing evidence supports that immune cell response may profoundly influence tumor progression. However, there are no calculated tools to systematically identify immune cells driven by specific somatic mutations. It is urgent to develop a calculated method to comprehensively detect tumor-infiltrating immune cells driven by the specific somatic mutations in cancer. We developed a novel software package (SMDIC) that enables the automated identification of somatic mutation-driven immune cell. SMDIC provides a novel pipeline to discover mutation-specific immune cells by integrating genomic and transcriptome data. The operation modes include inference of the relative abundance matrix of tumor-infiltrating immune cells, detection of differential abundance immune cells with respect to the gene mutation status, conversion of the abundance matrix of significantly dysregulated cells into two binary matrices (one for upregulated and one for downregulated cells), identification of somatic mutation-driven immune cells by comparing the gene mutation status with each immune cell in the binary matrices across all samples, and visualization of immune cell abundance of samples in different mutation status for each gene. SMDIC provides a user-friendly tool to identify somatic mutation-specific immune cell response. SMDIC may contribute to understand the mechanisms underlying anticancer immune response and find targets for cancer immunotherapy. The SMDIC was implemented as an R-based tool which was freely available from the CRAN website https://CRAN.R-project.org/package=SMDIC.
Bis(Triphenylamine)Benzodifuran Chromophores: Synthesis, Electronic Properties and Application in Organic Light-Emitting Diodes
Authors: Li Hui , Komatsu Ryutaro , Hankache Jihane , Sasabe Hisahiro , Lawson Daku Latevi Max , Özen Bilal , Chen Songjie , Hauser Jürg , Hauser Andreas , Decurtins Silvio , Kido Junji , Liu Shi-Xia
Published: July 2021

A series of bis(triphenylamine)benzodifuran chromophores have been synthesized and fully characterised. Starting from suitably functionalized benzodifuran (BDF) precursors, two triphenylamine (TPA) moieties are symmetrically coupled to a central BDF unit either at 4,8-positions through double bonds (1) and single bonds (2) respectively, or at 2,6-positions through double bonds (3). Their electronic absorption and photoluminescence properties as well as redox behaviour have been investigated in detail, indicating that the π-extended conjugation via vinyl linkers in 1 and 3 leads to comparatively strong electronic interactions between the relevant redox moieties TPA and BDF. Due to intriguing electronic properties and structural planarity, 3a has been applied as a dopant emitter in organic light-emitting diodes. A yellowish-green OLED exhibits a high external quantum efficiency (EQE) of 6.2%, thus exceeding the theoretical upper limit most likely due to energy transfer from an interface exciplex to an emissive layer and/or favorable horizontal orientation.
Beasts in the Garden: Human-Wildlife Coexistence in India's Past and Present
Authors: Oommen Meera Anna
Published: July 2021

Human-wildlife encounters are characterized by a diverse array of engagements located on the continuum between the negative and the positive. In India, protracted conflict with wildlife is reflected in violence across a range of rural and urban ecologies, but is only one aspect of the multiple facets of ongoing human-non-human encounter. Within these shared spaces, there are often equally significant elements of acceptance, tolerance and reverence. Together, these are dependent on context, and can be explored via lived experiences and worldviews, and a moral economy of human-wildlife and human-human relationships. Historically, though hardly static, such relationships have been mediated by the ontological positioning of traditional societies and their embedded rules and practises. In recent years, these tenuous equilibria have been disrupted by top-down catalysts, including universalist conservation agendas percolating from the state and the global arena. This study aims to explore the changing nature of coexistence by using several historical and contemporary vignettes in relation to key species that routinely “transgress” from their primary natural habitats into the “garden” spaces of human cultivation and habitation. The study will argue that insights at the intersection of environmental history, political ecology and anthropology can improve our understanding of human-wildlife coexistence in India as well as across the world.
Heart Failure With Mid-range Ejection Fraction: Every Coin Has Two Sides
Authors: Zhu Kaiyuan , Ma Teng , Su Yang , Pan Xin , Huang Rongrong , Zhang Fenglei , Yan Chunxi , Xu Dachun
Published: July 2021

This review summarizes current knowledge regarding clinical epidemiology, pathophysiology, and prognosis for patients with HFmrEF in comparison to HFrEF and HFpEF. Although recommended treatments currently focus on aggressive management of comorbidities, we summarize potentially beneficial therapies that can delay the process of heart failure by blocking the pathophysiology mechanism. More studies are needed to further characterize HFmrEF and identify effective management strategies that can reduce cardiovascular morbidity and mortality of patients with HFmrEF.