bluuebunny/crossref_metadata_2025 huggingface dataset:
Representación gráfica 3
Authors:   Universidad del Azuay, Larriva-Rivera Álvaro
Published: January 2023

Los modelos se describen en este avance, desde la información de las particularidades de sus componentes, como productos ensamblados. Con partes unidas, por un lado, por relaciones que se apoyan en sus formas bajo las leyes de la Geometría, mientras que en la estructura, al ser analizadas bajo un orden mecanicista 3 (partes de una máquina) resultan fáciles de ser entendidas como unidades separables del todo (componentes funcionales 4 dispuestos a la vez en partes materiales). Por estas consideraciones, según algunos autores, se estima esta etapa de la descripción del proyecto con la diferencia y la denominación de dibujo mecánico o dibujo industrial. 60 páginas ISBN: 9789978325841 e-ISBN: 9789978325810
Diseñar hoy: Hacia una dimensión más humana de diseño
Authors:   Universidad del Azuay, Tripaldi-Proaño Anna , Cáceres Milton ,   Universidad del Azuay, Ávila-Ochoa Ana Margarita ,   Universidad del Azuay, Bengoa Guillermo ,   Universidad del Azuay, Gutiérrez-Borrero Alfredo ,   Universidad del Azuay, Longinotti Enrique ,   Universidad del Azuay, Páez-Barrera Oswaldo ,   Universidad del Azuay, Fritche-Tamiset Jean Roger ,   Universidad del Azuay
Published: January 2023

Los textos evidencian la relevancia que hoy por hoy tiene el diseño como actividad profesional, los profundos impactos que puede llegar a tener y cómo estos nuevos enfoques pueden y deben insertarse en el nuevo discurso del diseño. Su lectura, además, nos recuerda la urgencia de diseñar hoy desde otra perspectiva, más humana, más cercana al contexto, a la gente, a sus necesidades y a las necesidades colectivas pensadas en términos de permanencia, de ambiente, de identidad, de inclusión, en fin, de un mejor vivir. Estas memorias se resumen en seis ensayos académicos, un relato fotográfico y una galería de imágenes que dan fe del espíritu crítico, propositivo y sensible de quienes están y siempre estarán reflexionando sobre lo que implica DISEÑAR HOY. 136 páginas ISBN 978-9978-325-48-3
Estudio de competencia mediática en los jóvenes de la ciudad de Cuenca
Authors:   Universidad del Azuay, Ugalde-Sánchez Cecilia , González-Cabrera Catalina ,   Universidad del Azuay
Published: January 2023

Investigación sobre el grado de competencia de los estudiantes y docentes de los colegios del Distrito Sur de la ciudad de Cuenca. Evaluación de los conocimientos sobre TIC y uso de medios en padres de familia del distrito norte y sur de la ciudad de Cuenca. Las tecnologías se han incrementado significativamente en la difusión de imágenes, y sobre todo en su potencialidad seductora. Sin embargo, no se observa una mayor formación en las personas para hacer que la imagen pase de ser una provocación hipnotizante a un recurso de aprendizaje y desarrollo ciudadano que fomente la reflexión crítica en la ciudadanía. Se parte de la absurda premisa que el consumo de medios garantiza de por si su aprendizaje para el visionado cuando los estudios parecen indicar la línea contraria, esto es que un consumo masivo de medios conlleva una menor toma de distancia de los mismos, un mayor desdibujamiento entre realidad/ficción y menor habilidad de comprensión integral de los mensajes. 194 páginas ISBN: 978-9978-325-60-5 e-ISBN: 978-9978-325-61-2
Arq UDA Proyectos 2017
Authors:   Universidad del Azuay, Sotomayor-Bustos Cris
Published: January 2023

La cadena del Taller de Proyectos Arquitectónicos constituye el principal eje de formación de los estudiantes de nuestra carrera. A medida que estas cátedras se imparten en cursos superiores, los niveles se complejizan, reciben aportes de distintas asignaturas, lo cual afina y profundiza los resultados alcanzados. Para ello se requiere de una coordinación académica horizontal que organice acciones y procesos que apunten hacia los logros esperados para cada nivel. Cabe destacar que las materias no son dependientes de los talleres, sino que en ciertos momentos aportan o hacen sentido en el Taller, es decir hacen sentido en la arquitectura. Los talleres de Proyectos Arquitectónicos se organizan verticalmente según los conocimientos, logros y resultados esperados para los estudiantes. 122 páginas ISBN: 978-9942-778-04-8 e-ISBN: 978-9942-778-05-5
Diseño, Arte y Arquitectura: Retos de la contemporaneidad
Authors:   Universidad del Azuay, Bustos-Cordero Leonardo
Published: January 2023

La presente publicación es el segundo producto de este sueño; un conjunto de textos trabajados con ética, responsabilidad y profesionalismo; avalado por docentes e investigadores de talla, nacionales y extranjeros. Se ha obtenido como resultado un trabajo de gran nivel, al abordar temas como: “Diseño emocional”; “Retos del diseño en nuevos sectores del contexto a través de la identidad y el pensamiento contemporáneo”; “Posibilidades del diseño y la identidad”; “El origen del teatro en el Ecuador”; “Los diarios se volvieron digitales ¿Evolución desde la óptica de la teoría darwiniana?”; “Los multimedia como generadores del arte escénico”; “Las estructuras como recurso expresivo de la arquitectura”. 120 páginas ISBN: 978-9978-325-46-9
Academia Ecuatoriana de la Lengua Memorias No 78
Authors: de la lengua Academia Ecuatoriana
Published: January 2023

Informe de labores presentado por la Directora de la Academia Ecuatoriana de la Lengua, doctora Susana Cordero de Espinosa, ante la Asamblea General reunida el 24 de enero de 2019. 680 páginas ISBN: 978-9942-822-20-8 eISBN: 978-9942-822-21-5
Las batallas de Torata y Moquegua
Authors:   Universidad Nacional Jorge Basadre Grohmann, Tacna, Perú, Peralta Casani Pedro Pablo
Published: January 2023

En enero de 2023 se conmemoran 200 años de las batallas de Torata y Moquegua, que significaron el trágico desenlace de la primera campaña de puertos intermedios, aquella empresa que estuvo liderada por la incipiente Junta de Gobierno del Perú y que culminó con la completa derrota del ejército unido patriota en los campos moqueguanos, costándole a estas fuerzas una cantidad de bajas que no serían superadas ni por las definitivas batallas de Junín y Ayacucho. Para Moquegua, estos combates significaron uno de los episodios más negros de su historia, ya que, una vez conseguida la victoria hispana sobre las fuerzas patriotas, una horda realista se internó en las desprotegidas casas de sus habitantes, saqueando y destruyendo sin reparar que básicamente mujeres y niños las ocupaban, lo que bien podría calificarse como uno de los mayores ensañamientos contra un pueblo en el contexto de las guerras de independencia. Aunque resulte sorprendente, poco o nada se ha escrito sobre estos hechos. Al silencio de los clásicos le acompaña la indolencia de los propios habitantes de Moquegua, que no tienen recuerdo, ni el más vago, de que alguna vez a la ciudad le tocó vivir circunstancias propias de una guerra de barbarie. Hoy no hay calle, avenida o plaza que recuerde a algún personaje de aquellas batallas o que rememore los saqueos, salvo un monumento reciente elaborado por el artista Róbinson Fernández, a quien le reconocemos tamaño gesto. Por ese motivo, el presente libro se entrega a la comunidad como un testimonio de lo acontecido durante las jornadas de enero de 1823. Es también un homenaje a los hombres y mujeres, del ámbito civil y militar, que tuvieron participación en los combates librados en Torata y Moquegua, en cuyas derrotas se encuentra la razón de su largo olvido. En ese sentido, esperamos que esta obra sea útil para todo aquel que desee conocer el sacrificio que tuvieron los habitantes del extremo sur peruano durante uno de los periodos más decisivos de la historia nacional.
Detection & Quantification of Lung Nodules Using 3D CT images
Authors: Memon Falak , jawaid Moazzam , Talpur Shahnawaz
Published: January 2023

In computer vision image detection and quantification play an important role. Image Detection and quantification is the process of identifying nodule position and the amount of covered area. The dataset which we have used for this research contains 3D CT lung images. In our proposed work we have taken 3D images and those are high-resolution images. We have compared the accuracy of the existing mask and our segmented images. The segmentation method that we have applied to these images is Sparse Field Method localized region-based segmentation and for Nodule detection, I have used ray projection. The ray projection method is efficient for making the point more visible by its x, y, and z components. like a parametric equation where the line crossing through a targeted point by that nodule is more dominated. The Frangi filter was to give a geometric shape to the nodule and we got 90% accurate detection. The high mortality rate associated with lung cancer makes it imperative that it be detected at an early stage. The application of computerized image processing methods has the potential to improve both the efficiency and reliability of lung cancer screening. Computerized tomography (CT) pictures are frequently used in medical image processing because of their excellent resolution and low noise. Computer-aided detection systems, including preprocessing and segmentation methods, as well as data analysis approaches, have been investigated in this research for their potential use in the detection and diagnosis of lung cancer. The primary objective was to research cutting-edge methods for creating computational diagnostic tools to aid in the collection, processing, and interpretation of medical imaging data. Nonetheless, there are still areas that need more work, such as improving sensitivity, decreasing false positives, and optimizing the identification of each type of nodule, even those of varying size and form.
Optimización de la secuenciación con penalizaciones por adelanto y atraso con trabajos que se traslapan
Authors: Bolaños Valenciano Camila , González Núñez Mauren Valeria , Mora Mora Luis Daniel , Valverde Solano Alejandro , Vargas Rodríguez Luis Enrique
Published: January 2023

El objetivo principal de la presente investigación es resolver el problema de secuenciación con penalizaciones por anticipación y penalizaciones cuadráticas por tardanza para la finalización tardía del trabajo. Se llevó a cabo una amplia investigación para identificar un faltante en los modelos existentes. Debido a esto, fue posible identificar que los modelos abordados por la literatura carecían de la posibilidad de superposición de trabajos. Por lo tanto, la propuesta parte de un modelo preexistente que optimiza las penalizaciones por entrega anticipada al insertar tiempos muertos que provocan la reducción de las penalizaciones por anticipación. El modelo propuesto parte de un método heurístico que proporciona una solución inicial. Además de esto, se plantea un algoritmo para insertar tiempo de inactividad que genera una primera optimización seguida de una segunda optimización debido a la superposición de trabajos de modo que un trabajo pueda comenzar antes de que se complete el trabajo que lo precede con el objetivo de reducir la penalización por finalización tardía. Para este estudio, se hicieron las siguientes suposiciones: se permite el tiempo de inactividad, el primer trabajo comienza en el tiempo cero, todos los trabajos son independientes y estos pueden superponerse hasta cierto límite de cumplimiento. Los resultados obtenidos al realizar la parametrización y simulaciones demuestran que a través de la superposición de trabajos se logra la reducción de las penalizaciones por tardanza, lo que lleva a la validación de la propuesta.
Primary Diffuse Large B-Cell Lymphoma of the Colon with Spontaneous Perforation: A Case Report
Authors: Hammemi Mehdi , Hajri Mohamed , Omrani Sahir , Ferjaoui Wael , Bacha Dhouha , Rached Bayar , Mestir Hafedh
Published: January 2023

We report a rare case of primary lymphoma of the colon with spontaneous perforation in A 54-year-old woman.
Effects of Bromelain on Noradrenaline Release During Anxiety-Like Behaviour Following Intra-Medial Forebrain Bundle 6-OHDA Injection in Rat Model of Parkinsonism
Authors: Adu Temitope , Adu Oluwatosin , Mabandla Musa
Published: January 2023

Introduction: Parkinson’s disease (PD) is characterized by emotional dysfunction which is a typical manifestation of non-motor symptoms. Non-motor symptoms may occur simultaneously with motor impairment in PD. Anxiety is a comorbidity in PD. This study therefore addresses the question of whether prior/post 6-OHDA lesion treatment with bromelain can show an effect on the behavioural signs of parkinsonism and damage to the CNS noradrenergic system in experimental rats. Methods: Open field and despair swim tests were used to assess certain psychomotor functions and emotional reactivity in the neurotoxin injected rats. The level of noradrenaline in certain regions of the brain as well as in the blood was further analyzed by enzyme linked immunosorbent assay. Findings: The results showed that unilateral injection of the neurotoxin into the rats’ medial forebrain bundle caused a decrease in the rearing time and a corresponding increase in the time spent grooming. There was a further indication that 6-OHDA injection resulted in the reduction of noradrenaline in the systemic environment. Also, the duration of immobility was increased by 6-OHDA injection but not statistically significant. Pretreatment with bromelain caused a change in the grooming behaviour not consistent with noradrenaline level. Conclusion: This finding suggests that bromelain treatment interferes with the regulation of mood and emotion during the early phase of parkinsonism in the 6-OHDA rat model of PD which was accompanied by changes in noradrenaline level.
Manajemen Pendidikan Karakter di SDN 1 Karanggayam
Authors: Darsono Darsono , Zakiyah Zakiyah
Published: January 2023

This research is based on the importance of character problems in students. In this regard, this study aims to determine the management of character education in moral student realization in SDN 1 Karanggayam. This survey is a qualitative survey. Data collection through interviews, observations and documentation. Validity of data using triangulation. Data analysis techniques include data reduction, data display, and inference drawing. This research led to his five conclusions: (1) Instill in students a sense of values and morality, and aim for character education. These values and morals align with the Madrasa's vision and mission. Instilled character stats include: Religious, sincere, hardworking, smart and caring. (2) The organization of character education, where teachers are role models for madrasah students, is working well. These values and morals are implemented in different ways depending on each teacher's style. (3) Character education leadership includes activities that improve teacher-student relationships, provide students with opportunities to voice their opinions, and motivate students. (4) The control of character education is done by providing students with the development of moral values and literacy. These skills are: Critical thinking, creative thinking, clear communication skills, listening skills, and good moral habits.
Meningkatkan Keterampilan Mengungkapkan Monolog Descriptive Lisan Sederhana yang Berterima Menggunakan Sistem ICARE di MTs Muhammadiyah 2 Kalibening Banjarnegara
Authors: Amin Nur Muhamad
Published: January 2023

The key output of the teaching process is the material provided by the students themselves,therefore it is important to conduct research. The methodology used in this investigation is aclass of investigative action. Methods of data collection using interviews, tests, observation,and documentation. Data validation using triangulation. Data analysis methods used in thisresearch include quantitative analysis, especially reduction analysis, presentation, andconclusion or verification analysis. The results of this study indicate that: (1) teaching Englishuses the ICARE system to teach one continuous monologue that is descriptive in nature andincludes four learning objectives: Introduce (Introduce), Connect (Connect), Apply (Apply),Reflect (Reflect), and Expand (Expand). (2) The results of Section I show that there are 16 or43% of participants who have completed the course and 27 or 67% who have not; the overallparticipation rate was 68. In Part II,
THE IMPACT OF OWNERSHIP STRUCTURE ON FIRM VALUE IN THE BANKING SECTOR COMPANIES
Authors:   Institut Teknologi dan Bisnis Kalbis Indonesia, Ubuddiyah Siti Paras , Ardillah Kenny ,   Institut Teknologi dan Bisnis Kalbis Indonesia
Published: January 2023

Research Purpose. This research aims to determine the effect of managerial ownership, foreign ownership, and family ownership on firm value. Research Method. This research uses quantitative methods. The population in this study is banking companies listed on the Indonesia Stock Exchange from 2016 to 2019. The sample was determined by purposive sampling technique and obtained 88 research samples based on specific criteria. The analytical method used is descriptive statistical analysis, panel data regression analysis, classical assumption test, and multiple linear regression analysis. Research Result and Findings. The results showed that managerial ownership and foreign ownership had an insignificant negative effect on firm value and family ownership had a significantly positive effect on firm value.
FINANCIAL DISTRESS AND MANAGERIAL ABILITY ON AUDIT FEE
Authors:   Universitas Prasetiya Mulya Indonesia, Lauwangsa Jovan Krishna , Suryadi Vanya Amartyazenna ,   Universitas Prasetiya Mulya Indonesia, Adelina Yang Elvi ,   Universitas Prasetiya Mulya Indonesia, Gunawan Vania Pradipta ,   Universitas Prasetiya Mulya Indonesia
Published: January 2023

Research Purposes. This paper examines the effect of managerial ability on audit fees, examines the effect of financial difficulties on the relationship between managerial ability and audit fees, and examines the effect of opportunistic reporting carried out by management in the form of earning management on audit fees. Research Method. The studies that were carried out used secondary data from 139 non-financial companies listed on the Indonesia Stock Exchange from 2016 to 2020. Research Result and Findings. Through a linear regression of panel data, the study found that higher amount of audit fees was positively influenced by the manager's ability to manage company resources and found that abnormal cash flow real earning management had a positive influence on audit fees. The study also found that financial difficulties did not moderate the relationship between a company's managerial ability and its audit fees, but found that companies with financial difficulties had higher audit fees.
SISTEM INFORMASI AKUNTANSI FORMAL-KULTURAL: STUDI CRITICAL ACTION RESEARCH
Authors:   Universitas Brawijaya, Mulawarman Aji Dedi , Lamase Muhammad Fadhir Abdullah Ido ,   Universitas Brawijaya, Ananda Meryana Rizky ,   Universitas Brawijaya, Ramadhani Febrina Nur ,   Universitas Brawijaya
Published: January 2023

Research Purpose. This study aims to design an accounting information system by integrating formal structure and cultural system in a book publishing business. Research Methods. The research was conducted with a critical action research approach which includes planning, action, critical observation, and critical reflection and redesign. Research Result and Findings. Based on the research results, the researcher proposes two things in the design of formal information systems, namely: (1) the use of Open Monograph Press (OMP) in the operational process; and (2) rearranging the flowchart according to the OMP-based operational system so that all functions become clearer and do not overlap. The cultural information system is designed based on family values and trust which turns out to have more important contribution than the formal accounting information system.
New era of lipid-targeting peptide antibiotics
Authors:   , Shukla Rhythm
Published: January 2023

The work presented in this thesis describes a detailed investigation to understand the
mechanism of lipid targeting antibiotics using an array of methods including
ssNMR, advanced microscopy techniques, computational analysis, and biophysical and
biochemical assays. Together, these methods enable a holistic description of the
supramolecular mechanism of lipid-targeting antibiotics such as teixobactin or clovibactin.

Chapter 1 introduces the current scenario antimicrobial resistance (AMR) and highlights the studies conducted on teixobactin to date. This chapter introduces the basics of ssNMR and other complimentary techniques. It also lays the foundation for the methodologies used in the following chapters to gain insights into the mechanism of lipid-targeting antibiotics, teixobactin and clovibactin.

Chapter 2 is adapted from a study published in Nature Communications in 2020. Here we
describe the mechanism of action of synthetic analogues of teixobactin, namely [R4L10] and
[L10]. With the help of ssNMR studies, we could solve the structure of the complex formed
between [R4L10]-teixobactin and its target, lipid II directly in membranes. Furthermore, we
investigated the impact of the membrane composition on the mode of action of [R4L10]-
teixobactin and demonstrate that the bacterial cell membrane affects the binding of the drug.

Chapter 3 is adapted from a study published in Nature in 2022 where we describe a new dual
mode of action for natural teixobactin. In this chapter, we determine the dual mechanism of
teixobactin from an atomic to supramolecular scale using ssNMR, HS-AFM, and confocal
microscopy. We present an atomically resolved ssNMR structure of the complex and elaborate on its evolution into fibrils and eventually micrometre-sized clusters which ultimately kill the bacteria. Based on our results we show that teixobactin ventures away from the classic 1-drug to 1-target ideology and uses a new type of antimicrobial action.

Chapter 4 is adapted from a publication that is currently under review. This chapter
emphasizes the discovery of a new antibiotic called clovibactin from the bacterial “dark
matter.” We use our established methodology to study and elucidate the novel mechanism of
clovibactin and showcase its multi-targeting action.

Conclusively in Chapter 5, we showcase some recently acquired and unpublished data on the effect of anionic lipids on teixobactin’s mechanism of action and propose future studies which can be conducted to expand on the role of anionic membranes on the activity of lipid-targeting antibiotics. We also discuss how the efficient methodology developed can be useful in studying lipid-targeting antibiotics at different length scales under varying membrane compositions to provide a complete overview of their mechanism and help in designing better drugs to tackle the problem of AMR.
PENGARUH MODEL PEMBELAJARAN DISCOVERY LEARNING UNTUK MENINGKATKAN BERPIKIR KREATIF PADA MATERI IPA SISWA KELAS V SDN 090 PEKANBARU
Authors: Meliansari Vika , Alpusari Mahmud , Alim Jesi Alexander
Published: January 2023

Tujuan dari penelitian ini adalah, agar peneliti tau apakah ada pengaruh dari model pembelajaran Discovery learning terhadap materi IPA dengan meningkatkan cara berfikir kreatif anak dapat diterapkan pada siswa sekolah dasar nantinya. Subjek penelitian ini adalah siswa kelas V di SDN 090 Pekanbaru yang berjumlah 74 siswa dengan 2 kelas, satu kelas untuk kelas eskperimen dan satu kelas nya lagi untuk kelas kontrol. Penelitian ini menggunakan model pembelajaran Discovery learning. Pengetahuan IPA siswa pada kelas eksperimen dengan menerapkan model pembelajaran Discovery learning dilihat dari rata-rata Pretest kelas eskperimen 77,30 termasuk tingkatan pengetahuan kurang dan kelas kontrol 76,11 termasuk tingkatan pengetahuan yang kurang, kemudian dilaksanakan Posttest rata-rata nilai kelas eksperimen sebesar 88,22 sedangkan pada kelas kontrol dilihat rata-rata nilai Posttest sebesar 80,97 hasil Posttest kelas eksperimen termasuk tingkatan pengetahuan baik, sedangkan kelas kontrol termasuk tingkatan pengetahuan cukup. Setelah mengolah data pada kelas eksperimen dan kelas kontrol dengan menggunakan uji t Terdapat pengaruh penerapan model pembelajaran Discovery learning, berdasarkan uji t Ha diterima dan H0 ditolak dengan sig (2-tailed) 0,010 < 0,05, dan terhadap peningkatan hasil belajar IPA siswa kelas V SDN 090 Pekanbaru.

 

Tujuan dari penelitian ini adalah, agar peneliti tau apakah ada pengaruh dari model pembelajaran Discovery learning terhadap materi IPA dengan meningkatkan cara berfikir kreatif anak dapat diterapkan pada siswa sekolah dasar nantinya. Subjek penelitian ini adalah siswa kelas V di SDN 090 Pekanbaru yang berjumlah 74 siswa dengan 2 kelas, satu kelas untuk kelas eskperimen dan satu kelas nya lagi untuk kelas kontrol. Penelitian ini menggunakan model pembelajaran Discovery learning. Pengetahuan IPA siswa pada kelas eksperimen dengan menerapkan model pembelajaran Discovery learning dilihat dari rata-rata Pretest kelas eskperimen 77,30 termasuk tingkatan pengetahuan kurang dan kelas kontrol 76,11 termasuk tingkatan pengetahuan yang kurang, kemudian dilaksanakan Posttest rata-rata nilai kelas eksperimen sebesar 88,22 sedangkan pada kelas kontrol dilihat rata-rata nilai Posttest sebesar 80,97 hasil Posttest kelas eksperimen termasuk tingkatan pengetahuan baik, sedangkan kelas kontrol termasuk tingkatan pengetahuan cukup. Setelah mengolah data pada kelas eksperimen dan kelas kontrol dengan menggunakan uji t Terdapat pengaruh penerapan model pembelajaran Discovery learning, berdasarkan uji t Ha diterima dan H0 ditolak dengan sig (2-tailed) 0,010 < 0,05, dan terhadap peningkatan hasil belajar IPA siswa kelas V SDN 090 Pekanbaru.
PENDIDIKAN MENENGAH PERTAMA DI MASA PASCA PANDEMI COVID-19: TRANSFORMASI, TANTANGAN DAN ADAPTASI PEMBELAJARAN AL-QURAN HADIST DI MTS NURUL ISLAM BOYOLALI
Authors: Al Firda Ainul Luthfia , Hafsoh Siti
Published: January 2023

Pandemi covid-19 dan catatan kelam pendidikan membuat seluruh lembaga pendidikan terpukul mundur. Tidak terkecuali Mts Nurul Islam Boyolali. Transformasi pendidikan dari berbagai cara turut dilakukan mulai dari pembelajaran secara online, tatap muka terbatas, blended learning hingga full tatap muka. Pada masa gencarnya Covid-19 self directed learning menjadi ujung tombak pemulihan pendidikan. Urgensi penelitian ini menitikberatkan pada transformasi, tantangan dan adaptasi pembelajaran Al-Quran Hadist di era pasca pandemi covid-19. Penelitian ini adalah penelitian studi kasus dengan prosedur penelitian mulai dari tahap persiapan, pelaksanaan, dan penulisan hasil serta publikasi. Hasil penelelitian ini ialah transformasi pembelajaran di Mts Nurul Islam dengan metode pembelajaran blended learning yakni menghubungkan metode konvensional dengan perkembangan teknologi digital. Output penerapan metode ini adalah implementasi siswa pada praktik kehidupan sehari-hari yang tercermin dari kepribadian dan karakternya yang sesuai dengan nilai-nilai islami.
PENERAPAN METODE MIND MAPPING UNTUK MENINGKATKAN MOTIVASI SISWA PADA PEMBELAJARAN IPS TERPADU KELAS VII DI MTS KHAIRUDDIN GONDANGLEGI
Authors: Al Maida Nur , Silvi Zahrotus
Published: January 2023

Penelitian ini bertujuan untuk meningkatkan motivasi belajar siswa pada mata pelajaran IPS di kelas VII MTs Khairuddin, Gondanglegi, Malang tahun pelajaran 2021/2022. Penelitian ini menggunakan penelitian Tindakan kelas (Classroom Action Research). Subjek penelitian adalah siswa kelas VII MTs Khairuddin sebanyak 13 siswa. Teknik pengumpulan data dalam penelitian ini adalah obsevasi, wawancara, angket dan dokumentasi. Hasil penelitian menunjukkan bahwa melalui penerapan metode Mind Mapping dapat meningkatkan motivasi belajar siswa pada mata pelajaran IPS. Dibuktikan dengan rata-rata mendapatkan nilai minimal angket motivasi belajar 75 dengan 3 orang siswa tuntas dan 10 orang siswa tidak tuntas dengan persentase nilai 69 pada siklus I dan 11 orang tuntas dengan presentase nilai 78,46 pada siklus II. Simpulan dalam penelitian ini adalah penerapan metode Mind Mapping dapat meningkatkan motivasi belajar siswa pada mata pelajaran IPS pada siswa kelas VII MTs Khairuddin, Gondanglegi, Malang
Primary Cutaneous Neutrophilic Disorders
Authors: Hogarth Victoria J. , Moriarty Bláithín
Published: January 2023

The ‘classical neutrophilic dermatoses’ comprise a spectrum of disorders characterised by rash and neutrophilia. The defining histopathological finding is of a sterile neutrophilic infiltrate. Differentiation from cutaneous infection is essential to diagnosis. Triggers including drugs, infections, and malignant processes, and underlying systemic disorders including inflammatory bowel disease, account for the majority of cases; thorough investigation should be undertaken to exclude these. Steroid-responsiveness is an almost universal finding. We describe these disorders in detail and discuss the many rare presentations and appropriate management.
Acute Liver Failure: A Dangerous and Challenging Syndrome
Authors: Canbay Ali , Gerken Guido
Published: January 2023

Despite progress in understanding the underlying mechanisms, acute liver failure (ALF) is still one of the major clinical challenges in hepatology. A wide variety of aetiologies, and similarly, variable courses of the disease, make it crucial to identify the cause of ALF in each individual patient. Conservative therapy is only available for some patients; for many others, liver transplantation remains the only curative option for ALF. Thus, early evaluation and prognostication of the ALF syndrome is warranted for a timely decision to list a patient for transplantation or even as high urgency. This review aims to compose our current knowledge on epidemiology, mechanisms, and prognosis in ALF, and to give a perspective for future studies in this field.
Percutaneous Coronary Intervention for Bifurcation Lesions: A State-of-the-Art Review of Techniques and Dedicated Devices
Authors: Sidhu Baldeep S. , Gerber Robert T.
Published: January 2023

Percutaneous coronary intervention (PCI) has become an integral step in the management of patients with ischaemic heart disease. Bifurcation lesions are commonly encountered in PCI and are regarded as the most technically challenging lesions to treat. The literature is saturated with studies that explore the best way to treat these lesions, with a variety of techniques introduced to enable stenting of both vessels. However, the optimal method is still undetermined. In this state-of-the-art review, we discuss the various strategies that are currently regarded as ideal, particularly those which involve one or two-stent techniques. Moreover, dedicated bifurcation devices have been developed to facilitate bifurcation stenting and improve outcomes. The role of these devices in this context is also uncertain, therefore we will discuss the current evidence for their use. Finally, a road map on the ‘tips and tricks’ to successfully perform bifurcation PCI is mentioned, which will aid any interventionist performing this procedure in an optimal manner.
Thrombus Aspiration
Authors: Jamil Gohar , Siddiqui Mohammed Ahmed , El Gendi Hossam
Published: January 2023

ST-segment elevation myocardial infarction results from acute occlusion of a coronary artery. Mortality is high in this acute coronary syndrome. Mechanical reperfusion by primary percutaneous coronary intervention (PCI) is the most effective method to restore coronary circulation. The ultimate goal of primary PCI is successful myocardial reperfusion. Thrombus aspiration (TA) using manual TA catheters has been reported to improve coronary and myocardial circulation. This, however, does not translate into long-term mortality benefit and may be associated with an increased risk of stroke. This article reviews the role of TA as an adjunct to mechanical reperfusion during PCI.
Clinical Proteomics: The Potentiality of Urine Analysis for Understanding Diabetic Nephropathy
Authors: Papale Massimo , Rocchetti Maria Teresa , Gesualdo Loreto
Published: January 2023

The incidence of diabetic nephropathy (DN) is constantly rising in parallel with the prevalence of type 2 diabetes and has been predicted to double within the next 15 years. Albuminuria is considered the earliest putative diagnostic sign of diabetic renal damage but it is poorly associated to the complex histopathological picture of glomerular and tubular damage hence, up to now, the accurate diagnosis of the DN requires renal biopsy. The identification of new biomarkers of DN is an urgent need since the proper management of the DN patients requires early and unbiased diagnosis. The Proteomics approach to the study of the human disease allows a large-scale characterisation of the protein content of a biological sample, and its application to urine may be a challenging but powerful strategy to identify new DN biomarkers. In this review we discuss the main results of a decade of proteomic studies focused on the urinary investigation of diabetic nephropathy.
The Evolving World of Chronic Kidney Disease Mineral Bone Disorder
Authors: Bellasi Antonio , Galassi Andrea , Cozzolino Mario , Di Iorio Biagio
Published: January 2023

Chronic kidney disease – mineral and bone disorder (CKD-MBD) is associated with a significant morbidity and mortality. In vitro and animal models suggest that phosphorous, calcium, parathyroid hormone, and vitamin D abnormalities, mediate the cardiovascular and bone diseases that characterise CKD-MBD and increase the risk of death. Currently, mineral abnormalities are corrected through phosphorous restriction, phosphate binders, calcimimetics and vitamin D administration. Nonetheless, data in humans that support the use of these compounds are still scarce, mainly based on observational studies. Thus, a considerable number of doubts and questions still challenge clinicians dealing with CKD patients and mineral metabolism imbalances. We herein critically review clinical evidence that support the use of different drugs in CKD-MBD.
Hymenoptera Stings and the Acute Kidney Injury
Authors: Dongol Yashad , Shrestha Rakesh Kumar , Aryal Gopi , Bhadrapura Lakkappa Dhananjaya Bhadrapura
Published: January 2023

Hymenoptera stings are a health concern. Apidae (bees), Vespidae (hornets, yellow jackets and wasps) and Formicidae (ants) are medically-important stinging insects under the order Hymenoptera. Clinical features from simple skin manifestations to severe and fatal organ injury are due to the hypersensitivity reactions and/or the toxic effects of the venom inoculated. Here we discuss on Hymenoptera stings involving apids (honey bees) and vespids (wasps, hornets and yellow jackets) and their effect on renal function and associated morphological changes in the kidney. Despite the differences in venom composition and quantity released per sting in two insect groups, both lead to similar medical consequences, such as localised normal allergic reactions, mild to severe anaphylaxis and shock and multiple organ and tissue injury leading to multiple organ failure. Acute kidney injury (AKI) is one of the unusual complications of Hymenoptera stings and has the basis of both immune-mediated and toxic effects. Evidence has proven that supportive therapy along with the standard medication is very efficient in completely restoring the kidney function without any recurrence.
A Note on Changing Approach to Diagnosis of Alzheimer’s Disease
Authors: Tartaglione Antonio , Del Sette Massimo
Published: January 2023

This short review summarises the conclusions of two different series of studies set out to revise the 1984 National Institute of Neurological and Communicative Disorders and Stroke – Alzheimer’s disease and Related Disorders Association (NINCDS-ADRDA) criteria for the diagnosis of Alzheimer’s disease (AD). The role of AD-pathology (AD-P), the characteristics of AD clinical expression, and the importance of positivity of biomarkers are concisely surveyed, and the diverging position of different research groups in reference to predementia AD are outlined. The importance of other factors such as age, inflammatory changes, and vascular pathology, which can variably interact with the main feature of AD, is signalled and some clinical questions are raised.
Facial Swelling as a Presenting Sign of Cholangiocarcinoma
Authors: Khaladkar Sanjay M. , Dilip Darshana , Chanabasanavar Vijetha , Bethireddy Nagireddy , Lamghare Purnachandra
Published: January 2023

Cholangiocarcinoma is a rare primary malignancy of the biliary tree, which usually presents late in the course of disease with jaundice, upper right quadrant pain, and cachexia. They frequently metastasise in the lungs, liver, bones, adrenals, peritoneum, and retroperitoneal lymph nodes. The incidence of cutaneous dissemination from cholangiocarcinoma is extremely rare, with the scalp being the commonest distant site of skin metastasis. The authors report the case of a 44-year-old female with Stage IV hilar cholangiocarcinoma, who presented primarily with tender facial swelling, prompting investigation and subsequent diagnosis. To the authors’ knowledge, this case is the first report of a cholangiocarcinoma presenting as facial metastasis. It highlights the need for early characterisation of cutaneous lesions, which are likely to be of neoplastic origin using histology, immunohistochemistry, and PET-CT scans, and reminds that biliary tree neoplasms are possible primary malignancies in cases of skin metastasis, especially in the head and neck region.
Умный город 5.0. Часть 1. Таксономия созидания: иммерсивное метамоделирование
Authors: ВОЛКОВ Андрей Анатольевич
Published: January 2023

Совокупность актуальных вызовов традиционному формату существования общества, идентичности и системе ценностей человека, обусловленная глобальным характером и динамикой изменений технологического, экологического, социального, гуманитарного, экономического и геополитического измерения действительности, составляет когнитивный дисбаланс прогресса культуры (социума) и цивилизации (технологий). Такой дисбаланс объективно ограничивает понимание, эффективность планирования, проектирования, использования и управления устойчивой инфраструктурой настоящего, потенциально фокусирует риски технологических и социальных катастроф в будущем. Среда созидания (в основном - города) становится уникальным многомерным пространством концентрации всех технологических (мультииндустриальных) и социальных (мультиценностных) флуктуационных переходов. Лишь ограниченно эффективно, нечетко и часто агрессивно человеку эти изменения формируют новые тренды сегментированных прорывных и неочевидных сквозных технологий на критическом пути эволюции, неопределенно и экспоненциально изменяя континуум "природа-человек-общество-среда созидания" в достаточной глобальному коллапсу степени. Однако фактическая трансформация традиционных форм и функций городов как инфраструктурной основы цивилизации, соответствующей изменяющимся культурным моделям, сегодня не адекватна ни сути, ни темпу формирования новой реальности. Изменения всех технологических сегментов действительности вместе с трансформацией системы ценностей и идентичности человека в терминах субъекта и объекта единой метамодели не рассматриваются. Представлена концепция иммерсивного созидания - трансформации действительности, включающей человека, и определенной в системе его ценностей и идентичности. Таксономия иммерсивного метамоделирования созидания, представленная в публикации, состоит из пяти уровней основного (прагматического) и трех уровней принципиального (идеологического) контуров. Кибернетика таксономии дополнительно формирует новую мультиразмерную концепцию цифровых двойников.
Student mathematics understanding through blended learning approach
Authors: Puspitorini Agusriyanti , Indraswari Nur Fitriyah , Aini Kurratul
Published: January 2023

This study aims to describe students' understanding of the concept of calculus by using a blended learning approach, namely online learning, face-to-face learning, and individualized learning. The subject are students of mathematics education STKIP PGRI Sumenep who has taken calculus course I representative of three categories, namely the category of students with high, medium, and low levels of ability. The data collection technique used a test in the form of five essay questions on indeterminate integral material, interviews to explore student responses using unstructured interview guidelines, and observation to determine student activity in the process of learning activities in calculus courses. The data analysis technique consists of three stages, namely data reduction, data presentation and drawing conclusions. The results show that students are only able to re-state concepts that have been studied before, but students have not been able to provide examples and non-examples as a form of understanding integral concepts and students in relating concepts are still not appropriate and in accordance with the procedure for solving integral problems.
Mass dimension one fields with Wigner degeneracy: A theory of dark matter
Authors: Ahluwalia Dharam , Hoff da Silva Julio Marny , Lee Cheng-Yang
Published: January 2023

Whatever dark matter is, it must be one irreducible unitary representation of the inhomogeneous Lorentz group or another. We here develop a formalism of mass dimension one fermions and bosons of spin one half, and show that they provide natural dark matter candidates. By construction, they are covariant under space-time translations and boosts. However, incorporating the rotational symmetry is non-trivial and requires introducing a two-fold Wigner degeneracy thus doubling the degrees of freedom for particles and anti particles from two to four. With Wigner degeneracy, we have a well-defined theory of mass dimension one fields of spin one half that are physically distinct from the Dirac field. They are local, Lorentz covariant and have positive definite Hamiltonians. The framework also has the potential to resolve the cosmological constant problem, and supply dark energy.
The dynamic change of serotype distribution and antimicrobial resistance of pneumococcal isolates since PCV13 administration and COVID-19 control in Urumqi, China
Authors: Guo Meng-Yang , Shi Xing-Hai , Gao Wei , Tian Ju-Ling , Yuan Lin , Yang Juan , Wumaier Dilinuer , Cao Jiang , Abulimiti Reziwaguli , Zhang Wen-Li , Yao Kai-Hu
Published: January 2023

Objective

This study aims to analyze the serotype distribution and drug resistance of Streptococcus pneumoniae isolated from children aged 8 days to 7 years in Urumqi, China, between 2014 to 2021, during which PCV13 was introduced in the private sector’s immunization program and COVID-19 control was administrated in the last 2 years.

Methods

Serotypes of S. pneumoniae isolates were determined by Quellung reaction, and their susceptibility against 14 antimicrobials were tested. According to the start year of PCV13 administration (2017) and COVID-19 control (2020), the study period was divided into three stages: 2014–2015, 2018–2019, and 2020–2021.

Results

A total of 317 isolates were involved in this study. The most common serotypes were type 19F (34.4%), followed by 19A (15.8%), 23F (11.7%), 6B (11.4%), and 6A(5.0%). The coverage rate of both PCV13 and PCV15 was 83.0%. The coverage of PCV20 was a little higher at 85.2%. The resistance rate against penicillin was 28.6% according to the breakpoints of oral penicillin, which would reach up to 91.8% based on the breakpoints of parenteral penicillin for meningitis. The resistance rates to erythromycin, clindamycin, tetracycline, and sulfamethoxazole-trimethoprim were 95.9%, 90.2%, 88.9%, and 78.8%, respectively. The PCV13 isolate was more resistant to penicillin than the non-PCV13 ones. There was not any significant change found in the serotype distribution since the PCV13 introduction and the COVID-19 control. The resistance rate against oral penicillin slightly elevated to 34.5% in 2018–2019 from 30.7% in 2014–2015 and then decreased significantly to 18.1% in 2020–2021 (χ2 = 7.716, P < 0.05), while the resistance rate to ceftriaxone (non-meningitis) continuously declined from 16.0% in 2014–2015 to 1.4% in 2018–2019 and 0% in 2020–2021 (Fisher = 24.463, P < 0.01).

Conclusion

The common serotypes of S. pneumoniae isolated from children in Urumqi were types 19F, 19A, 23F, 6B, and 6A, which we found to have no marked change since the PCV13 introduction and the COVID-19 control However, the resistance rate to oral penicillin and ceftriaxone significantly declined in the COVID-19 control stage.
Case Report: Life-threatening hypercalcemia associated with MMR-deficient endometrial carcinoma secreting parathyroid hormone
Authors: Liu Huazhen , Gao Dan , Huang Yongfa , Li Ji , Zhao Mengyun , Lu Zhaohui , Hu Ya , Wang Tao , Zhang Yingqiang , Wang Wenze , Cao Dongyan
Published: January 2023

Ectopic secretion of parathyroid hormone (PTH) is a rare cause of hypercalcemia in malignancy patients. A 56-year-old woman with life-threatening hypercalcemia was caused by poorly-differentiated endometrial carcinoma secreting PTH with concomitant nodular goiter mimic parathyroid tumors. The elevated level of PTH and calcium decreased immediately after cytoreductive surgery (CRS). The pathology confirmed mismatch repair (MMR)-deficient endometrial carcinoma with PTH expression. The patient received four-course chemotherapy and one-course immunotherapy after CRS. The disease progression led to multiple organ failure and death about five months after CRS. To our knowledge, this is the first case of hypercalcemia caused by MMR-deficient endometrial carcinoma with ectopic PTH secreting and the first report of malignancy associated hypercalcemia complicated with nodular goiter.
Gut microbial characteristical comparison reveals potential anti-aging function of Dubosiella newyorkensis in mice
Authors: Liu Tian-hao , Wang Juan , Zhang Chen-yang , Zhao Lin , Sheng Ying-yue , Tao Guo-shui , Xue Yu-zheng
Published: January 2023

Introduction

Previous study has indicated Dubosiella newyorkensis may act as a potential probiotic in age-related diseases. However, its detailed role in aging has not yet been promulgated. This study aimed to explore the potential anti-aging role of Dubosiella newyorkensis by comparing the anti-aging effect of resveratrol in young and old mice.

Method

Measurement of intestinal aging-related factors in colon and serum, and vascular endothelial function-related factors in serum were performed by enzyme-linked immunosorbent assay (ELISA). Gut microbial analysis of intestinal contents were identified by 16S rRNA gene sequencing.

Results

The effect of Dubosiella newyorkensis on reducing malondialdehyde (MDA) and increasing superoxide dismutase (SOD) in aged mice were greater than that of resveratrol. While the effect of Dubosiella newyorkensis on nitric oxide (NO) level was less than that of resveratrol, the reduction of vascular endothelial growth factor (VEGF) and pentosidine (PTD) was better than that of resveratrol in young mice. In young mice, Dubosiella newyorkensis promoted an increase in the beneficial genus Lactobacillus, Bifidobacterium and Ileibacterium less effectively as compared with resveratrol treatment. In aged mice, Dubosiella newyorkensis promoted the increase of Bifidobacterium, Ileibacterium less effectively than resveratrol, and promoted the increase of Akkermansia, Staphylococcus, Verrucomicrobiota expression better as compared with resveratrol treatment. Both young and old mice showed the same results for the remaining markers, including changes in gut microbial composition and predictions of function.

Conclusion

Dubosiella newyorkensis has similar anti-aging functions with resveratrol. Dubosiella newyorkensis may even be more effective than resveratrol in reducing oxidative stress, improving vascular endothelial function, and redistributing gut microbiota. The research provides an innovative strategy of Dubosiella newyorkensis to improve aging.