bluuebunny/crossref_metadata_2025 huggingface dataset:
The problem of semantization of mental state vocabulary in the explanatory dictionaries of the Russian language
Authors:   Pushkin Leningrad State University, Zamanova Ilona V.
Published: September 2024

The article deals with the problems of psychic state definition in common explanatory dictionaries. The term “semantization” stands for the process and result of verbal unit semantic content revealing with regard to the particular language system, so that it can be correctly used in speech or translated into another language. “The Great Academic Dictionary of the Russian Language” in 30 volumes (2004) and “The Dictionary of the Modern Russian Literary Language” in 17 volumes (1948–1965) were used as the basis for the research. Psychic state is understood in the article as a static uncontrolled object-free psychic process with hardly determining causality. The aim of the study was to identify the types of the definition problems; ultimately, we tried to suggest some possible ways to solve them. The following types were identified: there is no distinguishing of the states, feelings, properties meanings in the vocabulary definitions; the separation of the psychical state on the basis of properties and feelings lexical meaning is inconsistent and non-unified; formed on the basis of the psychic state the psychic figurative sense has been allocated not holistically; approximate interpretation by synonyms still be an unsolved problem. As a result of the study a hypothesis about the regular (but not productive) semantic derivation of psychical properties and feelings into the sphere of states, as well as physiological states into the sphere of psychical ones was also put forward. The article proposes to distinguish between states, properties and feelings. The semantic classification of verbs is suggested to use to prove the correctness of the distinction. In addition it seems necessary to insert the states into the psychical properties (the features of the subjects or objects) lexical meanings system, as well as into the feelings (psychical processes, that is directed at the object and have a clear causality). Also for definite lexemes it is seems to be necessary to insert a psychical states figurative meaning into the definition of the physiological ones.
Currículo e avaliação na América Latina
Authors: Pasini Juliana Fatima Serraglio , Franzi Juliana
Published: September 2024

Este artigo analisa o currículo escolar na América Latina, com as especificidades do Brasil, do Chile e da Bolívia. Realizamos uma pesquisa bibliográfica e documental, que evidencia leis e relatórios da análise curricular do Estudo Regional Comparativo e Explicativo, bem como outros documentos que versam sobre o currículo. A investigação aponta a força do neoliberalismo no contexto latino-americano, estimulando uma organização que padroniza o currículo educacional, visando favorecer as avaliações em larga escala e, por conseguinte, caminha na contramão da preservação e do respeito à diversidade e à pluralidade social e cultural. O estudo identifica a Unesco como uma agência internacional indutora das reformas educacionais e curriculares, atreladas à participação das escolas nas avaliações internacionais e na criação de instrumentos próprios de avaliação como forma de monitorar a qualidade da educação nos países latino-americanos. Os resultados revelam movimentos que assumem um contraponto ao neoliberalismo e destaca vozes dissonantes à lógica do capital na educação.
A morte em palavras e imagens em livros ilustrados latino-americanos
Authors: Almeida Elizabeth Guzzo de , Belmiro Celia Abicalil , Chaves Luíza Santana
Published: September 2024

Este artigo aborda o tema da morte em três livros ilustrados latino-americanos, explorando aspectos do contexto cultural de cada país. Es así (2010), de Paloma Valdivia (Chile), Camino a casa (2010), de Jairo Buitrago (Colômbia) e Rafael Yockteng (Peru) e Só um minutinho (2006), de Yuyi Morales (México). A fundamentação teórica se sustenta nos seguintes conceitos: livro ilustrado contemporâneo e suas categorizações, em Belmiro (2008), Nikolajeva e Scott (2011); multimodalidade, em Kress (2010), Kress e van Leuween (2001); e diferentes abordagens sobre a morte, em Kovács (2003); Paiva (2008). As análises se baseiam no método contrastivo que ressalta diferentes estratégias narrativas. Os dados revelam que a relação palavra-imagem nos livros analisados articula ética e estética, produzindo eventos de linguagem que evidenciam a importância do contexto histórico e cultural na compreensão das obras mencionadas.
Gênero e infância na pré-escola
Authors: Batista Maria Thaís de Oliveira , Santos Simone Cabral Marinho dos
Published: September 2024

O objetivo desse artigo é discutir o modo como as relações de gênero são vivenciadas em uma turma de Educação Infantil, a partir do olhar das próprias crianças. Fundamentado teoricamente nos estudos de gênero, o estudo analisa como essas construções influenciam percepções e comportamentos no ambiente escolar, numa perspectiva histórica e social (Louro, 1997; Beauvoir, 1980). O procedimento metodológico inclui observações diretas e entrevistas com as crianças, permitindo centralizar suas vozes e experiências. Os resultados revelam que as formas com que as crianças se expressam e atribuem significados às suas vivências variam entre meninos e meninas e entre diferentes grupos, frequentemente apresentando estereótipos de gênero, e, em outros momentos, apresentando vivências de transgressão. As reflexões indicam que esses estereótipos influenciam significativamente a construção das identidades de gênero, evidenciando a necessidade de uma abordagem crítica na educação infantil para desconstruir essas normas sociais.
Editorial
Authors: Araujo Marta Maria
Published: September 2024

.
Letramento informacional para formação crítica no uso da informação por estudantes do ensino médio
Authors: Aguiar Jaquissom , Carmo Sandra Ramos , Lessa Bruna
Published: September 2024

Este artigo tem como proposta apresentar práticas de letramento informacional desenvolvidas pela biblioteca escolar com estudantes do Ensino Médio. Para tanto, buscou-se conceituar o termo “letramento informacional” e sua relação com o ‘letramento educacional’, a fim de identificar os desafios e as possibilidades encontradas pelas escolas e bibliotecas no processo pedagógico, no que diz respeito ao uso da informação. A discussão está fundamentada na literatura especializada nos campos de estudo da Biblioteconomia e da Pedagogia. A metodologia utilizada foi a revisão sistemática de literatura, a partir da análise de artigos recuperados na Base Dados Referencial de Artigos e Periódicos em Ciência da Informação. As análises mostraram que práticas de letramento informacional desenvolvidas, a partir da parceria biblioteca e escola, por exemplo, oficinas, palestras, pesquisa orientada, sites educativos, entre outras ações, são fundamentais para a formação de estudantes competentes no uso crítico da informação.
The Impact of Psychological Empowerment of Nurses on their Job Involvement: A Descriptive Correlational Study
Authors: Ghasemi Sina , Torabi Mohammad , Jamasbi Mehrdad Maleki
Published: September 2024

Background

Psychological empowerment and job involvement of employees are critical indicators of healthcare organizational performance. These two factors are essential when managing workplace changes, enhancing individual and overall organizational performance, and increasing the job security of nurses.

Objective

This study explored how nurses perceive their psychological empowerment and job involvement and the relationship between these two factors.

Methods

This descriptive-correlational research was conducted on nurses working in 3 hospitals affiliated with Hamadan University of Medical Sciences in 2023. The sampling method used was quota-random sampling. The data related to the study were collected from valid questionnaires related to Spreitzer's developed Psychological Empowerment and Kanungo's Job Involvement. The data analysis was also conducted at the descriptive and inferential statistics level using SPSS version 16 software.

Results

In this study, 65.9% (N=128) of the participants were female and 34.1% (N=66) were male. The results showed that the level of nurses' perception of psychological empowerment and job involvement was at an average level. Also, the results showed a significant relationship between the total psychological empowerment score and nurses' job involvement (P-value<0.001, r=0.587).

Conclusions

Based on the results, increasing each dimension of PE among nurses can significantly enhance their job involvement, subsequently improving the quality of patient care and reducing additional costs. Job involvement has been tied to nurse health and quality of care. Given the significant positive relationship between job involvement and psychological empowerment, attention must be given to empowering nurses psychologically.
Investigating the State of Self-Expression and its Relationship with Adjustment and Self-Efficacy of Students: Evidence From a Cross-sectional Study in Southern Iran
Authors: Yusefi Ali Reza , Nasabi Narjes Sadat , Bahmaei Jamshid , Askarpour Hedyeh , Bordbar Shima
Published: September 2024

Introduction

The ability to express themselves, adjustment, and self-efficacy play an important role in the academic success of students. The purpose of this research was to investigate the state of self-expression and its relationship with adjustment and self-efficacy of University students of Medical Sciences in 2024.

Methods

This descriptive-analytical cross-sectional study was conducted on 290 students of various fields studying in the first semester of 2023-2024. Data were collected using standard self-expression, adjustment, and self-efficacy questionnaires. Data were analyzed with SPSS software version 23 using descriptive and inferential statistics, and t-test, ANOVA, and Pearson’s correlation coefficient were performed at a 5% significance level.

Results

The mean and standard deviation of self-expression, adjustment, and self-efficacy of the students were respectively 92.48 ± 17.36 out of 200, 123.87 ± 15.94 out of 335, and 48.31 ± 11.25 out of 85. This indicates the average level of self-expression and self-efficacy, as well as poor adjustment. Also, a statistically significant direct correlation was observed between self-expression with adjustment (p=0.002, r=0.328) and self-efficacy (p<0.001, r=0.516).

Conclusion

Self-expression and self-efficacy were estimated at a medium level, and adjustment was estimated at a low level. Based on the results, with the improvement of self-expression, the students' adjustment and self-efficacy will improve. Therefore, it is suggested that the officials of the university provide the conditions for improving the self-expression of students through educational workshops and increase their self-confidence and self-esteem. Subsequently, paying attention to the needs of students and trying to solve their problems will help to reduce incompatibility.
Multi-Objective Low-carbon Optimization of UHVDC System Based on AP-NSGA-II Algorithm
Authors: Lei Luo , Jun Yang , Bingyuan Tan , Xiong Xiao , Yizhou Chen , Jicheng Yu
Published: September 2024

Background:

Ultra-High Voltage Direct Current (UHVDC) system has a wide range of
applications in the energy field, and its transmission process will cause a large amount of carbon
loss. To reduce carbon loss under the premise of ensuring safety, it is necessary to construct a
carbon loss model of the UHVDC transmission system.

Methods:

In this study, we propose a multi-objective optimization model to achieve the goal of
low-carbon emissions, which considers carbon transaction costs and equipment safety and proposes
initialization improvement and congestion improvement.

Results:

Compared with the mainstream optimization algorithms, the results show that the improved
model achieves at least a 29.97 % effect in reducing carbon loss, reduces the carbon loss
by 1222.79 t, meets the requirements of the low carbon loss, transaction cost and high safety, and
realizes the triple goals of UHVDC transmission system.

Conclusion:

The model we proposed can effectively reduce carbon loss and carbon trading costs
on the premise of ensuring safety.
Preliminary In silico Analysis of Echinococcus granulosus Calreticulin for Enhanced Vaccine Design against Cystic Echinococcosis
Authors: Gorgin Zahra , Yousefi Mahzad , Ghiabi Shadan , Elahinia Ali , Yousefi Hamed , Aghmyouni Zahra Fadaeian , Jahani Negar , Asgari Amirhossein , Hamedi Erfan , Rajabi Romina , Rahmanian Parham , Hashemi Saeed , Zandieh Mohammad Arad , Majidiani Hamidreza , Motahari Alireza
Published: September 2024

Background:

A neglected zoonosis, Cystic Echinococcosis (CE), is most common in
developing nations worldwide. Vaccination is, therefore, helpful in preventing this disease.

Objective:

Predicting the main biochemical properties of E. granulosus Calreticulin (CRT) and its
possible B-cell and T-cell-binding epitopes as a valuable candidate for immunization was the goal
of the current study.

Methods:

Predictions were made to determine biochemical, antigenic, structural, and subcellular
characteristics, along with the immunogenic epitopes, using several online servers.

Results:

The extracellular 48.15 KDa protein exhibited no allergenicity, while possessing hydrophilicity
(GRAVY: -0.785), stability (instability: 33.88), tolerance to a wide range of temperatures
(aliphatic: 62.45), and 59 post-translational modification sites. The secondary structure mostly
comprised random coils and extended strands. The 3D model was generated using the Robetta
server (confidence: 0.72), and was rehashed and confirmed subsequently. Common B-cell epitopes
were discovered by three servers and screened for antigenic, allergenic, and solubility traits.
Moreover, MHC-associated epitopes for mice and humans were predicted in E. granulosus CRT
with subsequent screening.

Conclusion:

This work offers a foundation for further investigation in order to design an effective
vaccination against CE. Further empirical research on the examined protein solely or in combination
with other antigens is needed.
Endoscopic Treatment for Early Correction of Craniosynostosis in Children
Authors: Domínguez Leonardo , Rivas-Palacios Claudio , Barbosa Mario M. , Escobar María Andrea , F. Elvira Puello , García-Ballestas Ezequiel
Published: September 2024

Initial treatments for craniosynostosis involved strip craniectomies, but due
to unsatisfactory results in advanced stages, extensive cranial remodeling was
introduced, despite its risks and prolonged hospital stays. Over the last 30 years, strip
craniectomies have seen a revival, primarily due to the incorporation of minimally
invasive endoscopic-assisted surgeries (EAS) as pioneered by Jiménez and Barone.
EAS has shown marked advantages over older surgical methods, including shorter
surgical times, reduced bleeding, and fewer hospitalization requirements, all while
achieving comparable results in cranial deformity corrections. The most influential
factor in perioperative morbidity is surgical time. EAS has emerged as a promising,
effective treatment for craniosynostosis, suggesting its wider adoption in neurosurgical
settings. Considering the relationship between age, surgical time, and blood loss, EAS
may be suitably extended to children aged 6-12 months.
Russian Roulette of Thoracic Spinal Endoscopy: The Importance of Preoperative Identification of Adamkiewicz System
Authors: Vargas Roth A.A. , Moscatelli Marco , Lewandrowski Kai-Uwe
Published: September 2024

Thoracic endoscopic spine surgery is gaining traction. During thoracic
decompression, the arterial Adamkewicz system (AKA) can be encountered, with
potentially severe implications if injured. This chapter outlines a diagnostic protocol
and patient selection for the surgery based on a study examining surgical risks tied to
the radicular magna artery. The authors share insights from fifteen patients with
thoracic herniated discs and spinal stenosis who underwent preoperative CTA. This
assessed the anatomical relationship of the Magna radicular artery to the surgical area.
The Adamkiewicz artery's prevalent locations were T10/11 (15.4%), T11/12 (23.1%),
and T9/10 (30.8%). Patients were grouped into three categories based on their
pathology's proximity to the AKA foraminal entry. In five instances, the Magna
radicular artery entered the spinal canal near the nerve root at the surgery site,
prompting a surgical approach adjustment. The authors advocate for CTA evaluation to
gauge surgical risks and adapt thoracic discectomy techniques based on the magna
radicular artery's closeness to the pathology.
Comprehensive Introduction to Endoscopic Transforaminal Lumbar Discectomy With Trephines
Authors: Sančević Žanko Radovan
Published: September 2024

Endoscopic transforaminal lumbar discectomy (ETLD) with trephines
represents a minimally invasive surgical procedure for treating lumbar disc herniation.
This technique best suits the novice surgeon and offers several advantages over
traditional open surgery, including reduced tissue trauma, faster recovery, and
improved patient outcomes. It simplifies the placement of the endoscopic working
cannula by creating an initial working space under fluoroscopic guidance without the
need for an initial foraminoplasty. This chapter delves into the technical and procedural
aspects of ETLD with trephines, providing a detailed overview of the procedure, its
indications, contraindications, surgical steps, and potential complications. Furthermore,
we highlight the advantages and limitations of this innovative technique and discuss its
established role in spinal surgery
Identifying the V-Point During Cervical Endoscopic Unilateral Laminotomy with Bilateral Decompression
Authors: Hagel Vincent
Published: September 2024

Cervical endoscopic unilateral laminotomy for bilateral decompression (CEULBD) is a surgical technique that addresses central canal stenosis, often associated
with radiculopathy and myelopathy. Previous studies have demonstrated this method's
feasibility, safety, and effectiveness, highlighting its advantages over anterior cervical
discectomy and fusion (ACDF) in terms of surgical duration, blood loss, and hospital
stay. In this chapter, the author focuses on the surgical steps by illustrating the applied
surgical anatomy to enable aspiring endoscopic spine surgeons to lean about the key
steps this technique and to perform it safely and successfully. This author recommends
having an experienced spine surgeon in the operating room for the first several cases
before performing posterior endoscopic decompression of the stenotic central cervical
spinal canal alone.
Full-Endoscopic Cervical Medial Branch Neurotomy
Authors: Li Zhen-Zhou , Hou Shu-Xun
Published: September 2024

Full-endoscopic cervical medial branch neurotomy (FECMBN) is a
minimally invasive procedure for chronic cervical facet joint pain. The procedure
involves advanced endoscopic visualization and surgical instruments to achieve precise
neurotomy of the medial branch innervating the cervical pain facet joint complex. In
this chapter, the authors summarize the key features of the posterior full-endoscopic
cervical medial branch neurotomy, including its advantages over traditional nonvisualized radiofrequency-based ablation procedures regarding the treatment effect's
safety, efficacy, and durability. They employ illustrative step-by-step instructions that
the novice endoscopic spine surgeon can employ to execute the posterior fullendoscopic cervical medial branch neurotomy safely and effectively.
Endoscopic Posterior Lumbar Interbody Fusion (PLIF)
Authors: Lijun Li , Kai Jia , Chaofan Guo
Published: September 2024

Endoscopic Posterior Lumbar Interbody Fusion (PLIF) is a minimally
invasive surgical technique to fuse the lumbar vertebrae. This approach combines
endoscopy with the established PLIF procedure, reducing tissue damage, improving
visualization, and direct neural decompression. The smaller incision size, precise
visualization, and specialized endoscopic tools contribute to decreased postoperative
pain, faster recovery, and potentially improved patient outcomes. In this chapter, the
authors highlight the technical pearls of the endoscopic PLIF by going through the
surgery step-by-step with illustrative clinical and intraoperative examples. The authors
encourage novice surgeons to obtain specialized training and the necessary equipment
to mitigate the potential risks and complications, including damage to neural elements,
spinous process fractures, and implant-related problems. While the clinical examples
presented herein had excellent functional outcomes and considerable reductions in
preoperative pain levels, further research is needed to evaluate the long-term efficacy
and outcomes of endoscopic PLIF compared to traditional open procedures.
Combined Paramedian and Posterolateral Endoscopic Approach to Calcified Central Thoracic Herniation
Authors: Dos Santos Thiago Soares , Werlang Pablo Mariotti , Sudário de Lima e Silva Marlon
Published: September 2024

Thoracic endoscopic discectomy is gaining more popularity. Accessing the
thoracic spine through a small skin incision rather than large exposures required for the
traditional costotrasversectomy approach, the endoscopic technique alleviates pain and
neurological symptoms and improves patient outcomes by targeting the compressive
pathology directly. In this chapter, the author reviews the indications for the procedure,
the inclusion and exclusion criteria, and its technical caveats by illustrating the
application of endoscopic instruments and visualization systems. Preoperative
evaluation, including advanced imaging techniques, is crucial for accurate diagnosis
and surgical planning. Further, the author demonstrates the procedure's advantages,
such as reduced tissue trauma, decreased blood loss, shorter hospital stays, and faster
recovery than traditional open surgery. With appropriate patient selection and skilled
surgical expertise, thoracic endoscopic discectomy is capable of managing thoracic disc
herniation with comparable clinical outcomes compared to open techniques without
collateral tissue trauma.
Harnessing Natural Quorum Sensing Inhibitors to Prevent Porphyromonas gingivalis-Induced Oral Squamous Cell Carcinoma: An Innovative Approach
Authors: Naseef Pathoor Naji , Sankar Ganesh Pitchaipillai
Published: September 2024

The quest for effective cancer preventive strategies has led researchers to explore novel ways that go beyond conventional treatments. One such innovative method involves using natural quorum sensing inhibitory compounds to target Porphyromonas gingivalis, a periodontal pathogen that plays a major role in the development of oral squamous cell carcinoma. This letter highlights recent research on natural quorum sensing inhibitors and their implications in prevention of oral squamous cell carcinoma, aiming to shift the focus from treatment to prevention. Efficacy assessment and mechanistic insights are discussed to emphasize the significance of this approach.
Guía de campo para la estimación de factores de emisión y captura de gases de efecto invernadero (GEI) en agroecosistemas de marañón
Authors: Parrado Moreno Carmen Alicia , Mateus Cagua Diana Mayerly , Pulido Castro Sandra Xiomara , Peña Quiñones Andrés Javier , Bernal Riobo Jaime Humberto
Published: September 2024

Los agroecosistemas de marañón se consideran sistemas productivos estratégicos para el desarrollo agrícola de la altillanura en la Orinoquia colombiana. Este sistema se caracteriza por sus potenciales bajas emisiones de GEI e incrementos en la acumulación en las reservas de carbono, lo cual incrementa su interés en modelos de negocios basados en servicios ecosistémicos como los mercados de carbono. No obstante, es necesario evaluar estas potencialidades en la región. De acuerdo con lo anterior, la presente guía de campo tiene como objetivo brindar los lineamientos para la cuantificación de biomasa área y subterránea, el almacenamiento del carbono en suelos de agroecosistemas de marañón y su papel en estrategias de mitigación del cambio climático. Con base en estas actividades, es posible determinar de manera más certera y equitativa el acceso a diferentes incentivos financieros y no financieros por parte de los productores en el territorio.
Comparative Effectiveness of Health Communication Strategies in Nursing: A Mixed Methods Study of Internet, mHealth, and Social Media Versus Traditional Methods
Authors: Hamarash Mariwan Qadir , Ibrahim Radhwan , Yaas Marghoob Hussein , Abdulghani Mohammed Faris , Al Mushhadany Osama
Published: September 2024

Background

Effective communication is vital in health care, especially for nursing students who are the future of health care delivery. In Iraq’s nursing education landscape, characterized by challenges such as resource constraints and infrastructural limitations, understanding communication modalities is crucial.

Objective

This mixed methods study conducted in 2 nursing colleges aims to explore and compare the effectiveness of health communication on the web, through mobile health (mHealth) applications, and via social media among nursing students in Iraq. The research addresses a gap in understanding communication modalities specific to Iraq and explores the perspectives, experiences, and challenges faced by nursing students.

Methods

Qualitative interviews were conducted with a purposive sample (n=30), and a structured survey was distributed to a larger sample (n=300) representing diverse educational programs. The study used a nuanced approach to gather insights into the preferences and usage patterns of nursing students regarding communication modalities. The study was conducted between January 12, 2023, and May 5, 2023.

Results

Qualitative findings highlighted nursing students’ reliance on the web for educational materials, the significant role of mHealth applications in clinical skill development, and the emergence of social media platforms as community-building tools. Quantitative results revealed high-frequency web use (276/300, 92%) for educational purposes, regular mHealth application usage (204/300, 68%) in clinical settings, and active engagement on social media platforms (240/300, 80%). Traditional methods such as face-to-face interactions (216/300, 72%) and practical experiences (255/300, 85%) were preferred for developing essential skills.

Conclusions

The study underscores nursing students’ preference for an integrated approach, recognizing the complementary strengths of traditional and digital methods. Challenges include concerns about information accuracy and ethical considerations in digital spaces. The findings emphasize the need for curriculum adjustments that seamlessly integrate diverse communication modalities to create a dynamic learning environment. Educators play a crucial role in shaping this integration, emphasizing the enduring value of face-to-face interactions and practical experiences while harnessing the benefits of digital resources. Clear guidelines on professional behavior online are essential. Overall, the study expands the understanding of communication modalities among nursing students in Iraq and provides valuable insights for health care education stakeholders globally.
Calculating Optimal Patient to Nursing Capacity: Comparative Analysis of Traditional and New Methods
Authors: Ware Anna , Blumke Terri , Hoover Peter , Arreola David
Published: September 2024

Background

Optimal nurse staffing levels have been shown to impact patients’ prognoses and safety, as well as staff burnout. The predominant method for calculating staffing levels has been patient-to-nurse (P/N) ratios and nursing hours per patient day. However, both methods fall short of addressing the dynamic nature of staffing needs that often fluctuate throughout the day as patients’ clinical status changes and new patients are admitted or discharged from the unit.

Objective

In this evaluation, the Veterans Affairs Palo Alto Health Care System (VAPAHCS) piloted a new dynamic bed count calculation in an effort to target optimal staffing levels every hour to provide greater temporal resolution on nurse staffing levels within the Veterans Health Administration.

Methods

The dynamic bed count uses elements from both the nursing hours per patient day and P/N ratio to calculate current and target staffing levels, every hour, while balancing across nurse types (registered nurses to nurse assistants) to provide improved temporal insight into staff allocation. The dynamic bed count was compared with traditional P/N ratio methods of calculating patient capacity at the VAPAHCS, to assess optimal patient capacity within their acute care ward from January 1, 2023, through May 25, 2023. Descriptive statistics summarized patient capacity variables across the intensive care unit (ICU), medical-surgical ICU, and 3 acute care units. Student t tests (2-tailed) were used to analyze differences between patient capacity measures.

Results

Hourly analysis of patient capacity information displayed how the dynamic bed count provided improved temporal resolution on patient capacity. Comparing the dynamic bed count to the P/N ratio, we found the patient capacity, as determined by the P/N ratio, was, on average, higher than that of the dynamic bed count across VAPAHCS acute care units and the medical-surgical ICU (P<.001). For example, in acute care unit 3C, the average dynamic bed count was 21.6 (SD 4.2) compared with a P/N ratio of 28.6 (SD 3.2). This suggests that calculating patient capacity using P/N ratios alone could lead to units taking on more patients than what the dynamic bed count suggests the unit can optimally handle.

Conclusions

As a new patient capacity calculation, the dynamic bed count provided additional details and timely information about clinical staffing levels, patient acuity, and patient turnover. Implementing this calculation into the management process has the potential to empower departments to further optimize staffing and patient care.
Development of a Tablet-Based Outpatient Care Application for People With Dementia: Interview and Workshop Study
Authors: Supplieth Juliana , Lech Sonia , O’Sullivan Julie Lorraine , Spang Robert , Voigt-Antons Jan‐Niklas , Schuster Johanna
Published: September 2024

Background

Dementia management presents a significant challenge for individuals affected by dementia, as well as their families, caregivers, and health care providers. Digital applications may support those living with dementia; however only a few dementia-friendly applications exist.

Objective

This paper emphasizes the necessity of considering multiple perspectives to ensure the high-quality development of supportive health care applications. The findings underscore the importance of incorporating input from stakeholders and the needs of affected families into application development.

Method

A qualitative approach was chosen, consisting of three interviews and an expert workshop. The interviews and the workshop were recorded and transcribed, and qualitative content analysis was carried out according to the methodology described by Kuckartz with the support of MAXQDA.

Results

During the development phases of the application, team meetings and discussions took place. We found that general practitioners and family caregivers play pivotal roles in the treatment and care of people with dementia, often expressing specific preferences and suggestions regarding supportive and assistive technologies. Moreover, the successful development of a useful tablet application requires robust scientific and multidisciplinary discussions and teamwork within the health care community.

Conclusion

This paper underscores the necessity of including multiple scientific, clinical, and technical perspectives to ensure the high-quality development of supportive health care applications. Furthermore, adopting a spiral development approach inclusive of feedback loops is imperative for iterative refinement and enhancement of the application.
60 years of glorious journey. To the 60th anniversary of the State Institution “Institute of Gastroenterology of the NAMS of Ukraine”
Authors: Authors No
Published: September 2024

No Abstract
Muramyl peptide blend ameliorates intestinal inflammation and barrier integrity in cell culture model
Authors: Masiuk D.M. , Nedzvetsky V.S.
Published: September 2024

Background. The intestinal barrier is a crucial structure for maintaining the balance in permeability of digested food and restriction of microbial invasion from internal environment. Imbalance in these functions closely related to the initiation of intestinal epithelium reactivity and inflammation. Inflammation is the most common cause of intestinal dysfunction. Muramyl peptides (MPs) are small signaling molecules which stimulate intracellular receptors of pathogens and are potent regulators of cell response. However, molecular mechanisms of MP effect on intestinal cells remain unknown. The study of MP application to maintain viability of Caco-2 cells was aimed to explore the cytoprotective effect of MP-based probiotic on gut inflammation and intestinal barrier integrity. Materials and methods. Caco-2 cells were treated with 10–100 µg/ml lipopolysaccharide (LPS), 5–50 µg/ml MPs and combination of LPS + MPs. Cell viability was measured with MTT assay. Occludin content was detected with Western blotting. Enzyme-linked immunosorbent assay was applied to assess interleukin-8 (IL-8) production. Results. Obtained results have shown that LPS treatment with doses of 10–100 µg/ml induced in a decrease in cell viability and occludin content. On the contrary, IL-8 content was increased in LPS treatment that evidence the dose-dependent proinflammatory changes in Caco-2 cells. No significant changes were detected in the cells exposed to 5–50 µg/ml doses of MPs. However, application of 50 µg/ml of MPs inhibited IL-8 upregulation in LPS-exposed cells. Besides, MPs exhibited a dose-dependent cytoprotective effect in respect to cell viability at a dose of 20 and 50 µg/ml. Furthermore, MP dose of 50 µg/ml helped restore occludin content in LPS-exposed cells. Conclusions. Taking into the account that occludin is one of major components of tight junctions, MPs can restore epithelial barrier integrity in compromised gut. Observed results demonstrated that MPs is a promising agent in inflammation-induced intestinal injury and maintaining gut barrier function.
Features of the claudin 1 and 7 expression in the mucous membrane of the large intestine in symptomatic uncomplicated diverticular disease and acute uncomplicated diverticulitis
Authors: Dorohavtseva H.A. , Dorofieiev A.E. , Dyadyk O.O. , Myroshnychenko M.S. , Bibichenko V.O.
Published: September 2024

Background. Diverticular disease is one of the most common gastrointestinal pathologies, which mainly damages the large intestine and is manifested morphologically by the formation of sac-like protrusions (diverticula) of the intestinal wall. Today, the etiopathogenesis of diverticular disease remains debatable and needs to be fully understood. Changes in the claudin expression in the colonic mucosa and, accordingly, their structural instability may play a certain role in the development of both diverticular disease and its complications. The study aimed to determine the features of claudin 1 and 7 expression in the colonic mucosa of patients with symptomatic uncomplicated diverticular disease (SUDD) and acute uncomplicated diverticulitis (AUD). Materials and methods. Fragments of the colonic mucosa of 12 individuals without gastrointestinal pathology (group 1), biopsies of the colo­nic mucosa from the diverticular orifice of 34 patients with SUDD (group 2) and 26 patients with AUD (group 3) were analyzed. An immunohistochemical study used rabbit polyclonal antibodies to claudins 1 and 7. The PAST program was applied to process digi­tal indicators. The average indicators in groups were compared using the Student’s t-test and Mann-Whitney U-test. Results. A comprehensive morphological study revealed a decrease in the expression of claudins 1 and 7 in the colonic mucosa of patients with SUDD and AUD, more pronounced in those with AUD. In the large intestine mucosa of people without gastrointestinal pathology and patients with SUDD and AUD, firstly, the content of claudins 1 and 7 was higher in the surface epithelium compared to the epithelium of the intestinal glands, secondly, the content of claudin 1 predominated over claudin 7 content. Conclusions. The detected changes in claudin 1 and 7 expression in the colonic mucosa biopsies may underlie the development of diverticular disease and its complications.
Fedir Hlazunov — teacher and Latinist with a Ukrainian soul
Authors: Chaban M.P. , Shevtsova Z.I. , Gaponov V.V.
Published: September 2024

The article considers the origin and education of candidate of theology Fedir Hlazunov. It highlights his teaching career in various religious and medical educational institutions. A special attention is paid to his collaboration with the historian and academician Dmytro Yavornytskyi, particularly in the scientific archival commission. The article also explores Hlazunov’s friendship with church historian Vasyl Bidnov and his family, as well as with the artist Mykola Pohribniak. It includes the memoirs of Oleksandra Serafimova (daughter of the enlightener Ivan Truba) about Fedir Hlazunov and his wife, Anastasiia Harkavtseva. The article brings attention to the revival of Fedir Hlazunov, a representative of pe­dagogical science in the Dnieper region, whose Ukrainian spirit had long been unjustly forgotten.
Análisis morfo-estructural del Campo Volcánico Monogenético Guamuéz-Sibundoy (sur de Colombia)
Authors: Murillo-Orobio Lisbeth Tatiana , Chapuel-Cuasapud Darcy Lisbeth , Botero-Gómez Luis Alvaro , Murcia Hugo
Published: September 2024

El Campo Volcánico Monogenético Guamuéz-Sibundoy (CVMGS) está localizado en los Andes del Norte, sur de Colombia, en una depresión geomorfológica que se conoce como Valle de Sibundoy. Esta zona se encuentra influenciada por un conjunto de fallas relacionadas con el Sistema de Fallas de Algeciras. Con el objetivo de comprender la actividad tectónica registrada en los rasgos morfo-estructurales y la interacción con el CVMGS, se presenta una caracterización morfo-estructural a través del procesamiento de modelos digitales usando sistemas de información geográfica (SIG). Para esto, utilizando un modelo de elevación digital, se analizaron las pendientes, los drenajes, un mapa de aspectos y los lineamientos sobre un relieve sombreado, y se identificaron deflexiones en ríos y segmentos rectilíneos. El análisis evidencia que la concentración de lineamientos presentes en la zona de estudio puede relacionarse con zonas de daño de las fallas principales, con patrones de dirección WNW-ESE, NW-SE, NNE-SSW y NE-SW. Los lineamientos en sentido WNW-ESE y NW-SE se relacionan con la falla Sibundoy y el Sistema de Fallas de Algeciras, mientras que los lineamientos en sentido NNE-SSW y NE-SW con la falla San Francisco-Yunguillo. Los resultados permiten evidenciar fallas regionales que no han sido registradas en la literatura, así como proponer un modelo estructural basado en estos sistemas y la interacción con fallas transversales.
Analytical Method Development and Validation of RP-HPLC Method for Estimation of Venetoclax in Pharmaceutical Dosage Form
Authors: Rasal Shubham , Munipalli Vijay Kumar , Warde Sayali , Nayak Smita , Vaidhun Bhaskar
Published: September 2024

Abstract: A simple and new isocratic high-performance liquid chromatography (HPLC) method was developed for the quantitative determination of Venetoclax in its tablet dosage form. The chromatographic separation was achieved on Perkin C8 (15cm x 4.6mm id, 5µ) column. The mobile phase selected was buffer (25 mm ammonium acetate) adjusted to pH 3.0 with orthophosphoric acid and acetonitrile in the ratio of (55:45) v/v at a flow rate of 0.7ml/min with column temperature maintained at 400C and 10µl injection volume. The detection was carried out at 286nm by a UV-visible detector. The retention time of Venetoclax was found to be 4.19 minutes. The proposed method was linear over the range of 5-50µg/ml with a correlation coefficient (R2) of 0.9998. The limits of detection and quantification values were found to be 0.53µg/ml and 1.62µg/ml respectively. All validation parameters were within the limits as per the ICH guidelines. The results of validation parameters indicate that the developed HPLC method was specific, accurate, precise, rapid, reliable and reproducible, therefore it can be applied for routine quality control analysis of Venetoclax in its tablet dosage form.
Impact of Climate Change on Intensity-Duration-Frequency (IDF) Curves
Authors: Khan Muhammad Ibrahim
Published: September 2024

Climate change is one of the primary causes of variation in global weather patterns, including those of rainfall frequency and intensity. Due to this, there is an urgent requirement for updated strategies regarding the design and management of urban infrastructures based on reliable IDF curve estimations. The review paper aims at assessing the impact of climate change on IDF curves, the methodological approach for updating IDF curves, and the consequences for urban flood management. This paper synthesizes recent literature to provide an overview of how climate-induced changes in precipitation patterns call for a paradigm shift in the use of IDF curves
Nanoparticle drug delivery for reducing cytotoxicity and MDR risks to cancer patients
Authors: Wu Zhenggang
Published: September 2024

See PDF
Estimation of Labetalol Hydrochloride in bulk and formulation by UV-Spectrophotometric Area Under Curve.
Authors: Suryawanshi Akshada D. , Dhobale Shankar M. , Abhang Suchita R. , Patel Salim G.
Published: September 2024

The current work was carried out for estimation of labetalol hydrochloride in bulk and pharmaceutical dosage form by utilizing area under curve method (AUC) method .For this purpose the wavelength range 200-400 nm was selected .Distilled Water was used as a solvent throughout the work. The linearity was observed in concentration range 5-25 µg/ml (r2 =0.9788) for the method. The present was found which can be used for routine quality control analysis for spectrophotometric estimation of labetalol hydrochloride in bulk and dosage form.
Keywords: Labetalol hydrochloride, Area under curve (AUC), Distilled Water, UV Spectrophotometric.
The Drug Changing Sensitivity and Resistance Pattern of Different Antibiotics and their Minimum Inhibitory Concentration against Salmonella
Authors: Wani Nisar Ahmad , Kannaiyan Jaianand , Paulraj Balaji , Veeramani Veeramanikandan
Published: September 2024

see PDF for detail
Determination of Antibody Titration between Clinical and Community-Based Patients for O, H, AH and BH Antigens in Salmonella Samples
Authors: Wani Nisar Ahmad , Kannaiyan Jaianand , Paulraj Balaji , Veeramani Veeramanikandan
Published: September 2024

The aim of the study is to determine the baseline antibody titer of Salmonella bacteria in different positive samples with a view to establishing the significant titer for Widal agglutination test in Kashmir. The Widal test was performed on each serum. The slide agglutination test was first done and then positive samples were further subjected to tube agglutination for quantitative titration. The most commonly utilized diagnostic test for enteric fever is a Widal test, which detects agglutinating antibodies against the O, H, AH and BH antigens of S. typhi. The results of the Widal test showed that out of 413 samples 219 were positive for Antigen O, 165 were positive for Antigen H, 17 were positive for Antigen AH and 12 were positive for Antigen BH. The highest percentage cases were with Antigen-O whereas the lowest percentage was found in Antigen-BH. The difference between clinical and community-based patients have been studied.
Keywords: Aetiology, Antigen, Enteric fever, Morbidity, Salmonella typhi, Widal test.
Extraction, Isolation and Characterization Screening of Coccinia grandis
Authors: Ram Bindurani L G P , Singh Anoop
Published: September 2024

Herbal medicine is the oldest form of medicine known to mankind. It was the mainstay of many early civilization and still the most widely practiced form of medicine in the world today. Medicinal plants produce a diverse range of bioactive molecules, making them rich sources of different types of medicines. Coccinia grandis whole plant part is used in Siddha, Ayurveda, Unani, traditional and ethano medicinal system. The present study is focus on the phytochemical analysis of ethanolic extract of Coccinia grandis aerial parts. Qualitative and quantitative phytochemical analysis of this species extract confirms the presence of various phytochemicals like alkaloids, glycosides, phenolic compounds and steroids. Purification of isolated compounds has been done and characterization of isolated compounds performed through spectral techniques like IR, NMR, UV, Mass spectrum. UV spectra have shown maximum absorption due to substitution of functional group in compound A. The IR spectrum of compound A showed absorption bands characteristics of flavanol indicating the presence of hydroxyl and tinsoporin functionalities at 3449, 1375 and 1079 cm-1 respectively, indication of double bond were represented by 1689 cm-1. Peak at 1375 cm-1 represented C-H bending whereas NMR was also characteristic of phytotaxanol, exhibiting the hydroxyl proton signal at δ 5.21as a multiplet, which helped us to characterize this compound as taxaterone, tinsoporin A and B respectively
Keywords- Coccinia grandis, Phytochemical screening, Isolation, Mass spectrum
Drug Utilization Evaluation of Piperacillin and Tazobactum at a Tertiary Care Center in Hyderabad, India.
Authors: Jagarlamudi Anup , Vishali A.J. , Venkatesh S. , Shivani P. , Sailaja M. , Swapna K.
Published: September 2024

Drug use evaluation is an ongoing, systematic, criteria-based program of medicine evaluations that will help ensure appropriate medicine use. If therapy is determined to be inappropriate, interventions with providers or patients will be necessary to optimize pharmaceutical therapy. Empirical therapy forms the basis of treatment in India mostly and it is the responsibility of DTC (Drugs and therapeutics committee) to organize a DUE study and adopt suitable protocol for controlling irrational drug use. In our study we have developed a data collection form based upon WHO guidelines for conducting a DUE study on piperacillin and tazobactum use evaluation. To assess the usage of piperacillin and tazobactum at a tertiary care center Hyderabad compared to the indications for piperacillin and tazobactum use and standard treatment guidelines and provide recommendations to improve rational use of piperacillin and tazobactum at these hospitals and reduce the development of further antibiotic resistance, prevent ADRs associated with the drug, and to reduce the economic burden on the patient with inappropriate use. For conducting the evaluation process we had followed the standard guide lines formulated by WHO. The gender distributions of casesheets were male- 42, female- 23. Indication wise the distribution of case sheets were mostly treated for surgical prophylaxis, prophylaxis and infections. Out of 65 cases 65 (99%) has met the established criteria, they are as per STGs. Illness most frequently treated with piperacillin and tazobactum is ckd with acute deterioration (29.23%). The minimum number of days of treatment was 3 day and the maximum number of days of treatment was 14days.  All patient folders evaluated with regards to HD, SEPTIC SHOCK, PNEMOMEDIATINM etc were found to meet the standard criteria appropriate for piperacillin and tazobactum use with respect to dose, and dose frequency. However, in the case of dose duration the evaluation was found to be largely inappropriate for all the justified indications.