bluuebunny/crossref_metadata_2025 huggingface dataset:
The 20th Anniversary of the 2005 UNESCO Convention on the Protection and Promotion of Cultural Expressions : Are the Convention’s Objectives (still) “Fit for Future”?
Authors: von Schorlemer Sabine , Merkel Christine M.
Published: January 2025

For two decades, the 2005 UNESCO Convention on the Protection and Promotion of the Diversity of Cultural Expressions (DCE) has played a pivotal role in shaping international cultural policy. This article explores the actual relevance of the Convention's Objectives against the backdrop of current global challenges such as poverty, climate change, digitization, and gender equality. The authors reflect on the Convention’s effectiveness in fostering international cooperation, supporting cultural policies, and promoting the inclusion of culture in development agendas. Notwithstanding emerging obstacles, the Convention’s framework has consistently been reaffirmed and shown dynamic adaptability to new developments, particularly through its doctrinal intersections with human rights law and its influence on States’ cultural policies. Key institutional mechanisms such as the International Fund for Cultural Diversity and initiatives like the 'Fair Culture' movement underscore the Convention’s role in promoting sustainable cultural development and equitable trade in cultural goods and services. In conclusion, with its broad framework of Objectives, the 2005 Convention remains a vital instrument in fostering cultural diversity, capable of responding to evolving global priorities while advocating for solidarity and creative collaboration among member States and civil society.
Comparative assessment of immune profile in children under the influence of benz(a)pyrene and cold factor in a case-control study with modeling and verification of the results obtained in an in vivo experiment
Authors:   FBSI Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Dolgikh O.V. , Nikonoshina N.A. ,   FBSI Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Alekseev V.B. ,   FBSI Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Luzhetsky K.P. ,   FBSI Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
Published: January 2025

The comparative assessment of immune profile indicators in children under = benzo(a)pyrene and cold factor influence in a case-control study with the modeling and verification of obtained results in an in vivo experiment was performed. In the course of a case-control study in children under airborne benzo(a)pyrene exposure the signs of phagocytic leukocyte activity inhibition and specific haptenic hypersensitivity formation (IgG to benzo(a)pyrene) associated with blood contamination with benzo(a)pyrene were established. Revealed changes in the immune profile and xenobial biomedia composition in children under airborne benzo(a)pyrene exposure at a dose of 0.00761 mcg/(kg*day) in the subarctic urbanized area, it is comparable to its level in children living under the conditions of external environmental benzo(a)pyrene exposure at a dose of 0.08689 mcg/(kg*day) in an urbanized area in a temperate climate zone (p>0.05). The results of the experimental study of the immunotropic effects of oral benzo(a)pyrene exposure at an average daily dose of 0.175 mcg/kg*day and cold factor influence (15.1±2.6 °C) in vivo also show the signs of phagocytosis inhibition in mice (OR=7.33 - 16.20, p<0.05). At the same time, the minimum values of phagocytosis percentage, phagocytic number and phagocytic index are observed with the combined benzo(a)pyrene and cold factor effect which confirms the hypothesis of immunotoxic benzo(a)pyrene exposure effect modification by a cold factor
Keywords: benzo(a)pyrene; cold stress; children; immune profile; phagocytosis; in vivo experiment
Effect of Permanganate Ions on Corrosion Inhibition of Mg-Al-Mn Alloys Containing Different Amounts of Li
Authors: Kharytonau Dzmitry , Osipenko Maria , Ryl Jacek , Adamiec Janusz , Mordarski Grzegorz , Chaprasava Viktoryia , Skowron Konrad , Kurilo Irina , Almqvist Nils
Published: January 2025

Lithium-containing magnesium alloys are promising materials for high-demanding industrial applications. In the present contribution, three different AZ31 magnesium alloys AZ31-xLi (x = 4, 8, and 12 wt.%) were cast and their corrosion processes were examined in 0.05 M NaCl solution utilizing potassium permanganate as a potential corrosion inhibitor. The microstructure of the alloys was analyzed by scanning electron microscopy. Scanning Kelvin probe force microscopy demonstrated high susceptibility of the alloys to localized corrosion attack. Electrochemical techniques showed high effectiveness of the permanganate inhibitor (up to 97%) at concentrations starting from 10–50 mM. Post-corrosion surface analyses allowed establishment of the corrosion inhibition mechanism based on the reduction of permanganate ions on the surface of AZ31-xLi alloys to form an insoluble protective layer of Mn(IV) oxide.
Data Efficient Molecular Image Representation Learning using Foundation Models
Authors: Harnik Yonatan , Shalit Peleg Hadas , Bermano Amit , Milo Anat
Published: January 2025

Deep learning (DL) in chemistry has made significant progress, yet its applicability is limited by the scarcity of large, labeled datasets and the difficulty of extracting meaningful molecular features. Recently, molecular representation learning (MRL) has emerged as a powerful approach to these challenges by decoupling feature extraction and property prediction. In MRL, a deep network is first trained to learn molecular features from large, unlabeled datasets and then finetuned for property prediction in smaller, specialized domains. The advent of foundation models, which are large models trained on diverse datasets capable of addressing various downstream tasks, has also transformed the field of DL. For example, large language models (LLMs) like OpenAI’s GPT-4 can be finetuned with minimal additional data for tasks considerably different from their training. While MRL methods have been widely applied across chemical applications, these models are typically trained from scratch on molecular data. This study proposes that foundation models can serve as an advantageous starting point for developing MRL models. We explore this idea by leveraging OpenAI's CLIP vision foundation model as the backbone for MoleCLIP, a molecular image representation learning framework. On standard benchmarks, MoleCLIP requires significantly less molecular pretraining data to match the performance of state-of-the-art models. Furthermore, MoleCLIP outperformed existing models on homogeneous catalysis datasets, emphasizing its robustness to distribution shifts, which allows it to adapt effectively to varied tasks and datasets. This successful application of a general foundation model to chemical tasks highlights the potential of innovations in DL research to advance synthetic chemistry and, more broadly, any field where molecular property description is central to discovery.
Extending quantum-mechanical benchmark accuracy to biological ligand-pocket interactions
Authors: Puleva Mirela , Medrano Sandonas Leonardo , Lőrincz Balázs , Charry Jorge , Rogers David M. , Nagy Péter R. , Tkatchenko Alexandre
Published: January 2025

Predicting the binding affinity of ligand molecules to protein pockets is a key step in the drug design pipeline. The flexibility of ligand-pocket motifs arises from a wide range of attractive and repulsive electronic interactions invoked upon binding. Accurately accounting for all these interactions on equal footing requires robust quantum-mechanical (QM) benchmarks, which are scarce for ligand-pocket systems. In addition, the puzzling disagreement between ``gold standard'' Coupled Cluster (CCSD(T)) and Quantum Monte Carlo (QMC) methods [Nat. Commun. 12, 3927 (2021)] casts doubt on many existing benchmarks for larger non-covalent systems. Here, we introduce the ``Quantum Interacting Dimer'' (QUID) benchmark framework containing 170 non-covalent systems spanning equilibrium and non-equilibrium geometries that model chemically and structurally diverse ligand-pocket motifs. Symmetry-adapted perturbation theory shows that QUID broadly covers non-covalent binding motifs and energetic (exchange-repulsion, electrostatic, induction, and dispersion) contributions. Robust and reproducible binding energies are obtained using two complementary QM methods: LNO-CCSD(T) and QMC, achieving mutual agreement of 0.3 kcal/mol. Analysis of this benchmark data reveals that several dispersion-inclusive density functional approximations provide accurate energy predictions, though they exhibit discrepancies in magnitude and orientation of atomic van der Waals forces, which could influence the dynamics of ligands within the pocket. On the contrary, semiempirical methods and widely used empirical force fields require improvements, particularly in capturing non-covalent interactions (NCIs) for out-of-equilibrium geometries. The wide span of molecular dipole moments and polarizabilities in QUID also demonstrates flexibility in designing pocket structures to achieve desired binding properties. Therefore, QUID sets a new ``platinum standard'' for reliable and reproducible QM benchmarks of NCIs in larger systems and enhances our understanding of biomolecular ligand-pocket interactions.
“Writing” Crystal Phases in Amorphous Calcium Carbonate via Bio-Inspired Laser-Induced Patterned Transformations
Authors: Shaked Hadar , Polishchuk Iryna , Ben-Arie Niv , Dobrynin Daniela , Gainza Javier , Katsman Alexander , Pokroy Boaz
Published: January 2025

Biomineralization demonstrates nature's remarkable ability to precisely regulate mineral formation, controlling both polymorph selection and spatial organization. This fascinating level of precision has inspired our investigation into spatially controlled, laser-induced crystallization. To this end, we employed laser-induced patterned crystallization within a Mg-stabilized amorphous calcium carbonate (ACC) matrix, generating four distinct phases: calcite, stable dehydrated ACC, monohydrocalcite, and hydromagnesite. We investigated the parameters affecting phase formation and determined that it is governed by laser power and scanning rate. Our calculations allowed us to determine the temperature generated under these conditions, spanning a range of laser powers and scan rates, leading to the development of a model explaining the formation of each phase. This allowed us to reproducibly "write" crystal phases on the surface in a spatially controlled and rationally designed manner. This research presents a novel approach to laser-induced spatial patterning of multiple crystallographic phases through an amorphous precursor, opening new avenues for bio-inspired studies and offering fresh insights into crystallization mechanisms from amorphous precursors.
Isomerism and Solvent Interaction in Octamethyl Calix[4]pyrrole Complexed with Formate
Authors: Terry Lane , Foreman Madison , WEBER J. Mathias
Published: January 2025

We investigate the binding motifs of host-guest complexes of the anion receptor octamethyl calix[4]pyrrole (omC4P) with the formate anion using cryogenic ion vibrational spectroscopy in concert with density functional theory. The resulting IR spectrum in vacuo is compared to that in deuterated acetonitrile and acetone solutions. The formate-omC4P complex has three low energy isomers in vacuo:(i) one with an oxygen atom of formate interacting with three of the NH groups of omC4P and the other oxygen atom interacting with the remaining NH group; (ii) one with a single oxygen atom of formate interacting with all four NH groups of omC4P; and (iii) one with each oxygen atom interacting with two NH groups. Each complex geometry lowers the C4v symmetry of the receptor to C1, Cs, or C2v, respectively, and this symmetry breaking and isomerism is reflected in the broadening and pattern of the NH stretching modes of omC4P.
Simple, scalable production of ricinoleic acid-functionalized superparamagnetic nanoparticles, size- and shape-tunable, hydrophobic and hydrophilic
Authors: Reja Sohel , Vasudevan Sukumaran
Published: January 2025

Materials properties at reduced dimensions are heavily influenced by both size and shape and, consequently, the synthetic approach. The synthesis of superparamagnetic iron oxide nanoparticles (SPIONs) has been extensively explored in the literature; however, preparative routes that allow for precise particle size and shape tunability with the scope for surface functionalization and industrial scalability remain challenging. Secondly, taking into account the importance of green chemistry in nanomaterial synthesis, a synthetic protocol that limits the use of harmful chemicals is highly solicited. In this work, we outline a simple one-pot decomposition route that avoids the complexities involved in the preparation, separation, and purification of precursor complexes required of traditional preparative routes and, consequently, is easily scalable. Ricinoleic acid was employed as a greener alternative to oleic acid as both the metal complexing and the capping agent. The modified thermal decomposition route effectively bypasses the demanding precursor synthesis steps of the traditional thermal decomposition route while retaining its advantages. Minor modifications in the preparation scheme allow for the control of particle size and shape. Additionally, a simple and general NTA-mediated ligand-exchange protocol was outlined that can directly transfer the hydrophobic nanoparticles from the non-aqueous reaction mixture to an aqueous phase without the need for product separation from the crude reaction mixture. The general approach reported was extended to prepare monodispersed binary and ternary ferrite nanoparticles. Hydroxylation of the surface-attached ricinolate ligands was explored as a ligand modification strategy to render the nanoparticles hydrophilic and, thus, water-dispersible. X-ray diffraction indicated the presence of magnetite and maghemite phases. TEM images showed monodispersed nanoparticles with a narrow size distribution. EDS mapping showed the uniformity in cation distribution over the nanoparticles. XPS spectra were recorded for elemental analysis. The nanoparticles were superparamagnetic with a saturation magnetization of 41 emu/g.
Affordable Arsenic Detection Device Using Handmade Lokta Paper for Decentralized and Sustainable Manufacturing
Authors: Shrestha Ramdeep , Neupane Bhanu Bhakta , Giri Basant
Published: January 2025

The reliance on centralized manufacturing systems often shows vulnerability of global supply chains, as evidenced by disruptions during the COVID-19 pandemic and geopolitical conflicts. This study reports an affordable and portable paper strip sensor for arsenic detection in groundwater, developed using distributed manufacturing and sustainability principles. Handmade Lokta Paper (HLP), produced in the laboratory from bark of a native Lokta plant, Daphne, through eco-friendly methods, served as the sensor substrate. The HLP strip employed the Gutzeit reaction and integrated smartphone imaging for qualitative, semi-quantitative, and quantitative arsenic analysis. The assay optimization was achieved with 1% (w/v) HgBr₂ impregnation, 5-minute dipping time, 15-minute arsine exposure, and imaging within minutes. Testing of 21 groundwater samples from Nepal revealed strong agreement between the HLP strip and a commercial kit (Cohen’s kappa = 0.811). The HLP strip demonstrated a lower limit of detection (18 μg/L vs. 20 μg/L) and limit of quantification (54 μg/L vs. 61 μg/L). Most samples had arsenic concentrations below 10 μg/L, with few reaching Nepal’s regulatory limit of 50 μg/L. In addition to robust analytical performance, the HLP strip exemplifies the scalability and cost-effectiveness of arsenic sensors, with a production cost of USD 0.37 per test—significantly lower than commercial alternatives. This innovation may foster local economic growth, minimize supply chain dependency, and reduce environmental impact through the sustainable utilization of Lokta paper. The study highlights the potential of integrating traditional materials with advanced analytical techniques to address global health and environmental challenges while promoting regional resilience and sustainability.
Escribiendo la memoria olvidada de un pueblo
Authors: Lazos Ruíz Adi Estela , Cruz Tamayo Jonathan de Jesús , Falla Pech Rafael
Published: January 2025

Kiní es un pueblo inmerso en un enorme legado y riqueza ecológica y cultural por 3000 años de grupos mayas en la península de Yucatán, sin embargo prácticamente no ha sido estudiado y sus habitantes tienen interés en su patrimonio histórico y biocultural. El presente artículo tiene como objetivo compartir el proceso de elaboración de un libro sobre estos temas a partir de aparentemente pocas pistas. Se ha conformado un grupo multidisciplinario entre gente del pueblo que comparte sus conocimientos y memoria colectiva y colaboradores externos especialistas en diversos campos, para escribir su historia usando diversos métodos y fuentes que van desde la consulta de archivos, la historia oral, las colectas botánicas, talleres participativos, entre otros. Se espera que el libro resultante sirva a las próximas generaciones para valorar su territorio.
Deconstruction of semi-Orientalism and Balkanism in the Autobiographical Prose of Enzo Bettiza and Grytzko Mascioni
Authors: Dalmatin Katarina
Published: January 2025

The paper analyses the ways of deconstructing some dominant elements of semi-Orientalist and Balkanist discourse (as defined by Nino Raspudić and Maria Todorova) in the autobiographical prose of Enzo Bettiza and Grytzko Mascioni of the late 20th century. In the context of Bettiza’s deconstruction of Balkan myths about the causes and nature of the war in Croatia and Bosnia and Herzegovina in the 1990s in Esilio (Eng. The Exile), the paper focuses on his analysis of the role of the negative perception of elements of the Ottoman heritage in the creation of the ideological framework of the Greater Serbian ideology, as well as on the different functions of depicting Dalmatian hill people (Vlaji) in Esilio compared to those that motivated the depictions of Morlachs in the Italian semi-Orientalist tradition of the late 20th century. In the novel Puck by Grytzko Mascioni, the distancing from the Adriatic semi-Orientalist discourse is manifested in the refusal to attribute the cultural achievements of Dalmatia exclusively to Venetian and Italian influence, and in the privileged position of Dubrovnik in the representation of Croatian and Dalmatian identity. The detachment from semi-Orientalism in Puck takes the form of a strong intertextual dialogue with the birthplace of this discourse – Alberto Fortis’s Travels into Dalmatia.
Kršćanske teme i motivi muslimanskih pjesnika hrvatske književnosti od moderne do naših dana
Authors: Lončarević Vladimir
Published: January 2025

Promatramo li razvoj hrvatske književnosti s religijsko-konfesionalnoga motrišta, tada u njoj prepoznajemo tri kršćanska intencijsko-tendencijska sklopa: katolički, supstancijalan i nosiv, te protestantski i pravoslavni. Osim njih, važan sklop čini muslimanska odnosno islamska književnost. Polazište ovoga rada jest utvrditi doticaj između islamske i kršćanske duhovnosti na primjerima poezije muslimanskih pjesnika hrvatske književnosti. Tema je, nakon utvrđivanja njezine znanstvene relevantnosti i metodološko-hermeneutičkog pristupa istraživanju, obrađena prije svega uvidom u autorske pjesničke zbirke i relevantnu periodiku. Istraživanjem je obuhvaćeno sedamnaest pjesnika, a svi su, uz jednu iznimku, pokojni književnici. Kao sekundarna literatura konzultirana su i citirana isključivo djela pisaca islamskog kulturnog kruga. Tijekom istraživanja primjerima su utvrđene posebnosti tematsko-motivske uporabe kršćanskih imena i pojmova u poeziji svakoga od njih te neke zajedničke osobine, prije svega upućenost muslimanskih pjesnika u kršćansku vjeru (nazivlje, pojmovlje, nauk, tradiciju i dr.) te kontekst uporabe, bilo da je islamski svjetonazor očitovan odnosno primjetan ili nije. Zaključno, utvrđeno je da muslimanski pjesnici hrvatske književnosti za kršćanskim temama i motivima posežu kao za pristupačnim i poznatim sadržajima. Pritom zadržavaju religijsko-kulturne sadržaje islamskoga duhovnog kruga, što katkada rezultira prožimanjem islamsko-ga i kršćanskoga sadržaja. Ovaj rad nastojao je ispuniti svrhu svojevrsnoga uvoda u tematiku, koja, naravno, zahtijeva daljnja istraživanja.
Politički rituali socijalističke Jugoslavije u romanima Gorana Tribusona
Authors: Dragičević Marijana
Published: January 2025

Raščlambom triju romana Gorana Tribusona: Povijest pornografije (1988.), Ne dao Bog većeg zla (2002.) i Vrijeme ljubavi (2017.), u kojima se autor ponajprije bavi odrastanjem, mitologijom pop-kulture 1960-ih i raspadom naraštajnih ideala, nastojat će se provesti interpretacija političkih rituala u socijalističkoj Jugoslaviji. Poseban naglasak stavljen je na prikaz pionirske organizacije koja je, od samog početka školovanja, služila kao instrument pripreme djece za sudjelovanje u društveno-socijalističkom životu i formiranje takozvanog socijalističkog čovjeka. Kompleksan fenomen istražen je povezivanjem romantičarskih pokreta (u kojima se vide obredni temelji) i analizom književnosti kao izvora, uz pomoć aktualnih historiografskih istraživanja. Tragajući za odlomcima iz navedenih Tribusonovih djela koji su esencijalni u recepciji političkih rituala, tekst upućuje na simboličke akcije, ceremonije i ponašanja koja su provođena unutar političkog konteksta s ciljem etabliranja, jačanja i legitimizacije države u vrijeme kada je Tribusonov autobiografski subjekt bio dijete te i sam član Saveza pionira. Iz podudarnosti vremenskog slijeda, autora i protagonista, pred sobom imamo historiografsku podlogu s političkim imaginarijem socijalističke Jugoslavije. Kritički odmak autora uočava se u diskursu dominantnog poretka ironizacijom, podsmijehom i mimikrijom svakodnevlja u autorski prozni tekst.
Faktor Penyebab Kasus Cerai Gugat di Pengadilan Agama Bekasi Kelas 1 A
Authors: Fadilah Ali Romadhoni  , Encep Abdul Rojak
Published: January 2025

Abstrak. Terdapat peningkatan kasus perceraian di Pengadilan Agama Bekasi Kelas IA, yang didominasi oleh perkara cerai gugat pada tahun 2018-2022. Penelitian ini bertujuan untuk mengetahui faktor-faktor penyebab dominannya kasus cerai gugat yang diajukan di Pengadilan Agama Bekasi pada tahun 2018-2022 dan menganalisis terhadap tinjauan pasal 77 Kompilasi Hukum Islam (KHI) terhadap faktor penyebab dominan cerai gugat. Jenis penelitian ini adalah kualitatif dengan menggunakan pendekatan hukum-empiris. Sumber data yang digunakan adalah data sekunder, primer, dan tersier. Pengumpulan data pada penelitian ini menggunakan metode wawancara, dan studi pustaka. Kemudian, data yang dapat dianalisis yaitu menggunakan metode deskriptif kualitatif. Hasil penelitian ini menemukan bahwa terdapat peningkatan jumlah kasus cerai gugat dari tahun 2018-2022 di Pengadilan Agama Bekasi. Faktor ekonomi mendominasi sebab meningkatnya kasus cerai gugat di Pengadilan Agama Bekasi. Krisis ekonomi, pengangguran, dan kesulitan finansial adalah beberapa faktor utama yang memicu konflik dalam rumah tangga yang berujung pada cerai gugat. Berdasarkan analisis hukum Islam ditinjau dari pasal 77 Kompilasi Hukum Islam (KHI) menunjukan bahwa kegagalan dalam memenuhi kewajiban dapat menyebabkan salah satu pihak mengajukan gugatan cerai.
Abstract. There has been an increase in divorce cases at the Bekasi Class IA Religious Court, which was dominated by divorce lawsuits in 2018-2022. This study aims to find out the factors that cause the dominance of divorce lawsuits filed at the Bekasi Religious Court in 2018-2022 and analyze the review of article 77 of the Compilation of Islamic Law (KHI) on the dominant causal factors of divorce lawsuits. This type of research is qualitative using a law-empirical approach. The data sources used are secondary, primary, and tertiary data. Data collection in this study uses interview methods, and literature studies. Then, the data that can be analyzed is using a qualitative descriptive method. The results of this study found that there was an increase in the number of divorce cases from 2018-2022 at the Bekasi Religious Court. Economic factors dominate because of the increase in divorce cases in the Bekasi Religious Court. Economic crises, unemployment, and financial difficulties are some of the main factors that trigger conflicts in the household that lead to divorce. Based on the analysis of Islamic law reviewed from article 77 of the Compilation of Islamic Law (KHI), it shows that failure to fulfill obligations can cause one of the parties to file a divorce lawsuit.
Analisis Putusan Hakim tentang Keabsahan Akta Pengikat Hibah terhadap Penghibahan Tanah Bangunan
Authors: Nisfa Lailah Sya’ban  , Eva fauziah
Published: January 2025

Abstrak. Akta perikatan ‎hibah merupakan pendukung/perantara sebelum dibuatkannya akta hibah oleh PPAT. Namun dalam ‎prakteknya di lapangan akta pengikat hibah hadir sebagai akta pengesahan hibah. Penelitian ini merupakan penelitian hukum yuridis normatif dengan ‎teknik pengumpulan data dalam penelitian ini adalah penelitian kepustakaan atau library ‎research dan menggunakan sumber data yang mengutamakan data sukender dengan ‎mengoleh sumber-sumber dari putusan pengadilan, jurnal-jurnal dan buku. Hasil ‎penelitian ini menunjukkan bahwa pelaksanaan hibah di Indonesia dinyatakan sah harus ‎berdasarkan kepada akta hibah untuk dijadikan syarat dibuatnya sertifkat peralihan hak ‎di Kantor Pertanahan, sedangkan apabila pelaksanaan hibah didasari oleh akta pengikat ‎hibah tidak dibenarkan. ‎Konsep pertimbangan Hakim banding dalam terhadap putusan perkara didasarkan pada ‎peraturan Pasal 1676 KUHPerdata dan Pasal 1677 KUHPerdata jo Pasal 210 Kompilasi ‎Hukum Islam dan tinjauan hukum ‎positif terhadap putusan perkara rekonvensi berdasar pada Pasal 1682-1683 ‎KUHPerdata, dan PP Pasal 37 ayat 1 Nomor 24 Tahun 1997.‎
Abstract. The ratification of grants on land and buildings is based on the grant deed, but if the grant is based on a grant binding deed, it is not legally valid. However, in practice, in the field, the grant binding deed is present as a deed of grant ratification. The purpose of this study is to find out the provisions of the grant law and its implementation, to know the judge's considerations in deciding the case and how to review the positive law on the judge's consideration in granting the reconvention decision. This research is a normative juridical legal research with data collection techniques in this study is library research and uses data sources that prioritize consumer data by obtaining sources from court decisions, journals and books. The results of this study show that the implementation of grants in Indonesia declared valid must be based on the grant deed to be used as a condition for making a certificate of transfer of rights at the Land Office, while if the implementation of the grant is based on a deed of binding the grant is not justified. The concept of the appellate judge's consideration of the decision of the case is based on the provisions of Article 1676 of the Civil Code and Article 1677 of the Civil Code in conjunction with Article 210 of the Compilation of Islamic Law and the grantor is in accordance with the provisions of Article 1685 of the Civil Code and the deed of binding the grant based on Article 1320 of the Civil Code, and a positive legal review of the decision of the reconvention case based on Articles 1682-1683 of the Civil Code, and PP Article 37 paragraph 1 Number 24 of 1997.
Corrimentos Vaginais
Authors: Fernandes Graziele Mariano , Zacarias Maria Luiza Sá , Kashiwabara Tatiliana Geralda Bacelar
Published: January 2025

O corrimento vaginal é um sinal comum que desperta preocupação a respeito da saúde ginecológica, principalmente durante a idade reprodutiva. Sabe-se que tal secreção varia de acordo com a faixa etária, como também durante as fases do ciclo ovariano, alternando em quantidade, cor e consistência.
Alimentação Complementar
Authors: Freitas Júlia Sther Saraiva , Leite Gabriela Vidal , Kashiwabara Tatiliana Geralda Bacelar
Published: January 2025

O período de alimentação complementar é caracterizado pela transição gradual do aleitamento materno ou da alimentação com fórmula infantil para a introdução de alimentos sólidos na dieta do bebê, é um momento fundamental no desenvolvimento infantil, não apenas devido às mudanças rápidas nas necessidades nutricionais e seu impacto no crescimento e desenvolvimento, mas também pela influência na formação de preferências de sabor e hábitos alimentares que podem afetar a saúde a longo prazo.
VIII Jornadas Mercosul: Memória, Ambiente e Patrimônio
Authors: Carelli Mariluci Neis , Meira Roberta Barros , Ferreira Rute Henrique da Silva , Leal Noris Mara Pacheco Martins , Graebin Cleusa Maria Gomes , Waismann Moisés , Rosa Lúcia Regina Lucas da , Chagas Wagner dos Santos , Almeida Fábio Chang de , Almeida Alexandre de
Published: January 2025

A Memória, o Ambiente e o Patrimônio formam um tripé que afeta, direta ou indiretamente, consciente ou inconscientemente, o modo de ver e de conhecer um povo, uma comunidade, uma organização, uma família, enfim, o próprio ser que está inserido no meio em que vive e com o qual interage. No ano de 2024, uma temática relevante foi escolhida para nortear os debates e sensibilizar o público: os entrelaçamentos das memórias e patrimônios culturais. Através de mesas-redondas foram contempladas as relações dessas temáticas com memória social, meio ambiente e patrimônio em contextos regionais e internacionais. Buscou-se mostrar, sobretudo, a necessidade de se discutir modelos de desenvolvimento que, através de suas políticas públicas, não coloquem em risco o patrimônio, a sustentabilidade, a segurança ambiental, as tradições culturais e o bem-estar da população. A realização da VIII Jornadas Mercosul na modalidade híbrida teve como objetivo facilitar a participação do público de fora do Rio Grande do Sul, considerando as dificuldades de transporte aéreo que ainda estávamos vivenciando desde as enchentes de maio de 2024. As reflexões realizadas nos três dias possibilitaram uma troca fértil de experiências, informações e pesquisas entre Instituições nacionais e estrangeiras, contribuindo para o desenvolvimento de ações e práticas que poderão vir a subsidiar políticas voltadas para uma expansão de investimentos sustentáveis na área de abrangência da Memória, do Ambiente, do Patrimônio. A presente coletânea de resumos resultante do Evento, está dividida em nove Grupos de Trabalho, sob responsabilidade de pesquisadores da Universidade La Salle e de Instituições parceiras, como a UNIVILLE, FACCAT, FURB, UPF, UFPEL, UFMT, UFRRJ, entre outros.
Recurrent Pancreatitis Associated with CFTR Heterozygous Mutation
Authors: Tuğçe Şevval Yıldız , Şeyma Şenocak
Published: January 2025

This case report discusses a 74-year-old male patient diagnosed with recurrent pancreatitis associated with a CFTR heterozygous mutation. The patient presented with complaints of epigastric pain, and laboratory findings revealed elevated amylase and lipase levelsGenetic testing revealed a p.Phe1052Val (c.3154T>G) heterozygous mutation in the CFTR gene, which has been associated with recurrent pancreatitis through autosomal dominant inheritance. A cystic lesion detected in the pancreas (suggestive of IPMN or serous cystic neoplasm) was evaluated for malignancy and deemed low-risk based on PET-CT findings and a negative CA 19-9 level. This case is presented to emphasize that CFTR mutations should be considered in the differential diagnosis of patients with recurrent pancreatitis, that symptoms may present in adulthood, and that the diagnosis can be easily established through genetic testing.
Understanding Burnout Rates for Clinicians and Physical Symptoms of Allostatic Load
Authors: Breshell Jackson Nevels , Tamice Jones , Derek A Nevels , Bruce Copeland , Teloria Sutton , Linda Askew
Published: January 2025

Burnout among clinicians is a pressing concern worldwide, manifesting as emotional exhaustion, depersonalization, and reduced professional efficacy. This article explores the intersection of burnout and allostatic load, the physiological burden resulting from chronic stress, to elucidate the consequences for healthcare providers. Burnout impacts clinicians’ mental and physical health, leading to compromised patient care, reduced job satisfaction, and increased attrition rates. A comparative analysis of recent scholarly works reveals converging evidence on systemic contributors such as excessive workloads, inadequate support systems, and organizational inefficiencies, further compounded by individual vulnerabilities like lack of resilience. These challenges have been exacerbated by the COVID-19 pandemic, which has significantly increased stress levels among healthcare professionals globally.
This article synthesizes insights from studies conducted between 2020 and 2024, emphasizing the need for holistic approaches to mitigate burnout. It highlights the physiological underpinnings of allostatic load, including chronic dysregulation of stress-response systems that predispose clinicians to adverse health outcomes like cardiovascular diseases, immune dysfunction, and mental health disorders. To address these issues, the article proposes a multidimensional strategy encompassing organizational reforms, evidence-based interventions, and policy advocacy. Recommendations include reducing administrative burdens, fostering supportive work environments, and integrating wellness programs targeting both systemic and individual stressors. Limitations and directions for future research emphasize the importance of inclusive, longitudinal studies focusing on diverse populations to develop tailored solutions. This comprehensive approach aims to enhance clinician well-being and improve healthcare outcomes globally.
The Ailments and their Treatments & Function of Integumentary Systems: A Details Review
Authors: Niranjan Kumar
Published: January 2025

A details development in recent dermal studies being carried out and purposed dermal studies is investigated in this research review globally and the various disease and process functions and treatment with symptoms and etiology and pathophysiology of skin-related issues are studies and practically feasible solution of various integumentary systems related problem and it’s function is researched and almost 30 types of common skin related diseases and remedies studies by researcher and it’s company KIRDPL in global perspectives and especially in tropical climate zone in various cases in patients is mentioned including plastic surgery to gene therapy and dermabrasion to the genetic disease as well. The integumentary systems in the animal kingdom as a whole are focused and homosapiens' human dermal functions and their development and future developments of stem cells laboratory-grown skin coats of different colors for shedding and treatments of cancerous skin and integumentary system and gene therapy of the ailments are discussed.
Haematopoietic Cell Transplants in Adults Acute Lymphoblastic Leukaemia in a Resource-poor Middle East Country
Authors: Khalid Halahleh , Isra Muradi , Nazmi Kamal , Ayat Taqash , Fareed Barakat , Hadeel Abdelkhaleq , Mohammad Khalil , Lina Halahleh , Waleed Da’na , Nidal Almasri , Mohammad Makoseh , Ammar Alamarneh , Al-Far Al-Far Rozan , Husam Abu-Jazar , Robert Peter Gale
Published: January 2025

Background: Outcomes of chemotherapy in adults with ALL in resource-poor countries are reportedly worse compared with outcomes in resource-rich countries. There are few comparative data on transplants in these settings.
Methods: Retrospective analysis of 102 consecutive subjects > 18 years with ALL receiving an allotransplant from Jan 2007 to Sept 2022 in Jordan.
Results: Median follow-up is 38 mo ([IQR] 16-80 mo). 81 subjects were men. The median age was 29 y(IQR 22-36 y). 63 were B-cell and 38, were T-cell lineage. 31 had the Ph-chromosome. 68 were in 1st and 34, ≥ 2nd histological complete remission. 97 received intensive conditioning. Donors were an HLA-identical sibling (N = 88) or an HLA-mis-matched relative (N = 14). Grafts were blood cells. Subjects received conventional GvHD prophylaxis, cyclophosphamide (N = 11) or ATG (N = 3). All subjects recovered bone marrow function with complete donor chimerism. 5-year leukemia-free survival (LFS), 58% (47, 69%) and survival, 45% (34, 56%). 45 subjects developed acute and 44, cGvHD. 3-year cumulative incidence of cGvHD was 28% (15, 42%). 5-year CIR was 32% (18, 45%) and 3-year NRM, 25% (15, 35%).
Conclusion: Allotransplant outcomes in adults with ALL in Jordan, a resource-poor country, seem comparable to those reported in resource-rich countries.
La pedagogía de la Nueva Escuela Mexicana vista desde la Escuela Activa
Authors: Hernández Santos Marcelo
Published: January 2025

Este texto plantea reflexiones sobre la pedagogía en la Nueva Escuela Mexicana analizándola desde el movimiento de la Escuela Activa en México que se dio a mediados del siglo xx. El artículo se basa en la historia del tiempo presente. También se sustenta en las investigaciones sobre la Nueva Escuela Mexicana y el planteamiento de la Escuela Activa de los Estados Unidos de América que tuvo una influencia marcada en México. Metodológicamente, se hace un análisis desde la relación presente-pasado retomando los documentos oficiales/legales que dieron origen al proyecto educativo actual y se confrontan y/o comparan con los planteamientos de la Escuela Activa de los años veinte del siglo pasado. Se basa en la producción escrita que hay sobre esta en México y en las reflexiones sobre las reformas educativas durante el neoliberalismo en México. Las ideas del siglo pasado sirven para ver el contenido pedagógico de la Nueva Escuela Mexicana. También se analiza la manera en que se desmarcó del contenido (no de todo) de las reformas precedentes, sobre todo las que se originaron en la época del neoliberalismo que datan desde el año 1992, 2004, 2009 y 2013, para llegar a la reforma actual en el 2019. El hallazgo es que la reforma educativa actual se explica con más claridad desde el pasado (Escuela Activa). Las conclusiones recuperan la vigencia de las ideas pedagógicas de la Escuela Activa o Escuela Nueva para explicar el proyecto educativo del presente basado en los métodos activos y el uso del contexto inmediato que han sido, desde el siglo pasado, los mejores facilitadores para la consecución de aprendizajes significativos en los estudiantes de la escuela básica en México.
Factors affecting practical training in health training institutions in Tanzania
Authors: Peter Abraham Sala  , Elia Michael Gidashi
Published: January 2025

Background: In Tanzania has 192 registered middle level health and allied sciences training institutions offering certificate and diploma level programme. One of roles the Ministry of health is to produce a competent and qualified health personnel to offer quality health services to the citizen. Despite all the effort put in place by the Ministry of health, clinical practical training faces many challenges. This study aimed to identify the factors affecting practical trainings (skill laboratory and clinical rotations) in health training institutions.

Methods: Cross-sectional study design was used to find out factors affecting practical training. A self-administered questionnaire was used to collect data from 213 participants selected using a simple random sampling method.

Results: 185 (87%) of students had inadequate knowledge on skills laboratory training and 181(85%) of had inadequate knowledge on clinical rotation. Most of the resources for skill laboratory and clinical rotation were available. An average time spent by students during skill laboratory training and clinical rotation training was 2 week and 13 weeks respectively. A mean of frequency of students’ supervision during skill laboratory practical training and clinical rotation practical training was 2.

Conclusion There is inadequate knowledge and supervision on skill laboratory and clinical rotation among students. Most of the resources for practical training are available
Influences of technological competencies and ethical practices of corporate social responsibility on consumer brand preference
Authors: Richard Mwenda Mate
Published: January 2025

The broad objective of this study was to establish the moderating effect of technological competencies on the relationship between ethical practices of corporate social responsibility and consumer brand preference for mobile phone services in Kenya. Data was collected using a structured questionnaire and analyzed through descriptive and inferential statistics. Findings suggest that technological competencies significantly moderate the relationship between ethical practices of corporate social responsibility and customer brand preference. These findings call for continuous involvement of mobile phone service companies in corporate social responsibility practices as it positively influences consumer brand preference. Future research should aim at establishing contextual and geographical differences in consumer preferences by targeting other countries with different social economic conditions.
Application of quantum computing in healthcare billing - USA
Authors: Rohan Desai
Published: January 2025

Quantum computing has emerged as a revolutionary technology, especially for data driven industries like healthcare. Inefficiency, inaccuracy, and fraud have kept the U.S. healthcare system at bay in its coding and billing processes. This research examines the use of quantum computing to improve healthcare billing through process optimization, fraud detection, and security. It therefore gives, through theoretical analyses coupled with algorithmic demonstrations, actionable insights into how quantum computing could transform healthcare billing.
Cloud-based master data management (MDM) solutions: Revolutionizing enterprise data strategy
Authors: Atul Ramesh Bharmal
Published: January 2025

Cloud-based Master Data Management (MDM) solutions are revolutionizing how organizations handle critical data assets in today's rapidly evolving digital landscape. These solutions offer enhanced scalability, flexibility, and real-time access capabilities that traditional on-premises systems struggle to match. By leveraging advanced technologies such as artificial intelligence, machine learning, and microservices architecture, cloud-based MDM enables organizations to achieve superior data quality, improved operational efficiency, and better business outcomes. This comprehensive article explores cloud-based MDM solutions' key features, benefits, implementation challenges, and future trends. It emphasizes their transformative impact across customer management, product information, financial data orchestration, and supply chain optimization domains. This article examines the transformative potential of cloud-based MDM, detailing how organizations can achieve up to 68% data accuracy improvement and 52% cost reduction while leveraging advanced technologies like AI and blockchain.
Prevalence of urinary pathogen and antimicrobial susceptibility of isolates in cervical cancer patient attending BPKMCH Bharatpur, Chitwan
Authors: Bishnu Ram Sedai  , Amar Nagila  , Dhaka Raj Pant  , Promish Neupane  , Rajan paudel  , Prashant  Prandit
Published: January 2025

Introduction: This study aimed to identify urinary tract infections in cervical cancer patients treated at BPKMCH Bharatpur, Chitwan, and test isolates for antibiotic susceptibility. Cervical cancer, a disease with abnormal cell development, can spread to other parts of the body. Treatment modalities like surgery, chemotherapy, radiation, and anticancer medication increase the risk of infections.

Methodology: Urine samples from cervical cancer patients at BPKMCH, Chitwan, were processed using standard guidelines in the Microbiology Laboratory. Isolates were identified using biochemical tests and techniques. Pure colonies were tested for antimicrobial susceptibility on Mueller Hinton agar (MHA) using Kirby-Beur disc diffusion method, following CLSI guideline 2017.

Results: A study of 350 cervical cancer specimens revealed that 43.1% contained significant growth of microorganisms, with Escherichia coli having the highest predominance at 35.9%. Staphylococcus aureus was the most prevalent Gram positive organism, with most isolates resistant to Ampicillin, Cotrimoxazole, and Cefixime. Polymyxin B and Imipenem were most effective for Gram Negative bacilli, while Vancomycin and Azithromycin were most effective for Gram Positive cocci.

Conclusion: Out of 350 patients, 43.1% had a UTI. Cervical cancer patients are more likely to get UTI as a result of immunosuppressive medication therapy and invasive surgery. As a result, they should be evaluated on a regular basis for the development of UTI, and their treatment should include AST. Such hospital-based study should be conducted to establish empirical therapy of UTI among cervical cancer patients with UTI, as well as to ensure adequate treatment and care.
Effect of Two Constant Rate Infusions of Lidocaine on the Anesthetic Requirement of Isoflurane in Pigs (Sus scrofa domestica)
Authors: Hampton Chiara E , Riebold Thomas W , Mandsager Ron E , Kleine Stephanie A
Published: January 2025

Lidocaine infusions are used in several species to reduce anesthetic requirements and decrease the negative impact of high inhalant concentrations on the cardiorespiratory system. The objective of this study was to determine the effect of 2 dosages of lidocaine administered as constant rate infusions on isoflurane requirement (IR) in swine and to measure plasma concentrations of lidocaine and, its metabolite, monoethylglycinexylidide (MEGX) corresponding to IR. Six healthy commercial-bred pigs aged 74 ± 5.3 d and weighing 31.7 ± 5.4 kg were anesthetized and maintained with isoflurane during mechanical ventilation. Baseline IR was determined using a supramaximal mechanical stimulus on the dewclaw of the hind limb. After randomization for treatment allocation, lidocaine (loading dose; 2 mg/kg IV) was administered, followed by either 50 (CRI50) or 200 (CRI200) µg/kg/min and maintained for 30 min to reach a steady state and redetermination of IR. The study was repeated with the alternate infusion rate after a minimum washout period of 6 d. Lidocaine and MEGX plasma concentrations were quantified with HPLC and compared between groups. Heart rate, arterial blood pressure, end-tidal partial pressure of carbon dioxide, body temperature, and time to extubation were measured and compared between treatment groups. Baseline IR was 1.77% ± 0.34%. In pigs receiving CRI50 (1.53%) and CRI200 (1.61%), IR was lower than baseline IR, with a sparing effect of 7.8% (P = 0.046) and 13.4% (P = 0.041), respectively. Plasma concentrations of MEGX were inversely correlated to IR in pigs receiving CRI50 but not CRI200. Cardiovascular variables did not differ between treatments. Time to extubation was similar between groups (P = 0.92), 10.2 ± 4.5 min in subjects receiving CRI50 and 11 ± 3.6 min in pigs receiving CRI200. Infusion of lidocaine produced a nonlinear sparing effect on isoflurane requirement without appreciable, clinically relevant changes in cardiovascular variables or extubation time.