bluuebunny/crossref_metadata_2025 huggingface dataset:
Measurement of Ejection Fraction by Cardiac Magnetic Resonance Imaging and Echocardiography to Monitor Doxorubicin-Induced Cardiotoxicity
Authors: Tak Tahir , Jaekel Camilla M. , Gharacholou Shahyar M. , Dworak Marshall W. , Marshall Scott A.
Published: October 2019

Doxorubicin is a standard treatment option for breast cancer, lymphoma, and leukemia, but its benefits are limited by its potential for cardiotoxicity. The primary objective of this study was to compare cardiac magnetic resonance imaging (CMRI) versus echocardiography (ECHO) to detect a reduction in left ventricular ejection function, suggestive of doxorubicin cardiotoxicity. We studied eligible patients who were 18 years or older, who had breast cancer or lymphoma, and who were offered treatment with doxorubicin with curative intent dosing of 240 to 300 mg/m2 body surface area between March 1, 2009 and October 31, 2013. Patients underwent baseline CMRI and ECHO. Both imaging studies were repeated after four cycles of treatment. Ejection fraction (EF) calculated by both methods was compared and analyzed with the inferential statistical Student's t test. Twenty-eight eligible patients were enrolled. Two patients stopped participating in the study before undergoing baseline CMRI; 26 patients underwent baseline ECHO and CMRI. Eight of those 26 patients declined posttreatment studies, so the final study population was 18 patients. There was a significant difference in EF pre- and posttreatment in the CMRI group (p = 0.009) versus the ECHO group that showed no significant differences in EF (p = NS). It appears that CMRI is superior to ECHO for detecting doxorubicin-induced reductions in cardiac systolic function. However, ECHO is less expensive and more convenient for patients because of its noninvasive character and bedside practicality. A larger study is needed to confirm these findings.
Evidence for the effect of serotoninergic and dopaminergic gene variants on stress levels in horses participating in dressage and harness racing
Authors: Negro S. , Sánchez-Guerrero M. J. , Bartolomé E. , Solé M. , Gómez M. D. , Membrillo A. , Molina A. , Valera M.
Published: October 2019

Eye temperature assessed with infrared thermography is an adequate tool for stress level assessment in sport horses’ competitions having a moderate heritability. Serotonin and dopamine signal transduction-linked gene variants have been associated with anxiety-related traits in several species. In this study we examined the association between 10 gene variants in BDNF, COMT, HTR1A, TPH2 and SLC6A4 genes (and the haplotypes at SLC6A4 gene) with stress level (measured with eye temperature and heart rate) in 270 animals, 135 Spanish Trotter Horses (STH) participating in trotting races and 135 ‘Pura Raza Español’ (PRE) horses in dressage. Association analyses were performed using a unified mixed model (counting for population structure and individual relatedness) for the whole population and for each horse breed. The g.43865600G > A intronic gene variant located 11.0 kb downstream from the transcription start site of SLC6A4 gene was associated with an increase in eye temperature before competition with a relative contribution of this gene variant of 38.8% (P = 0.001), 31.8% just after (P = 0.001) and 29.8% 2 h after the competition (P = 0.003). In STH, the g.43865600G > A gene variant showed the same association with eye temperature before (P = 0.001, contribution 27.2%), just after (P = 0.0003, 29.0%) and after the competition (P = 0.002, 17.5%); and the c.*111G > A gene variant located at the 3′UTR region of COMT gene was associated with eye temperature 2 h after the competition (P = 0.001, 22.3%). These results showed that SLC6A4 and COMT gene variants are associated with stress level measured as eye temperature increase during competitions, and may be promising tools for genetic testing against resistance at high stress levels in trotter horses.
Evidence of site fidelity and deep diving behaviour of scalloped hammerhead shark (Sphyrna lewini) around the Saint Peter and Saint Paul Archipelago, in the equatorial Mid-Atlantic ridge
Authors: Bezerra Natalia P. A. , Macena Bruno C. L. , Travassos Paulo , Afonso Pedro , Hazin Fábio H. V.
Published: October 2019

Seven scalloped hammerhead sharks (Sphyrna lewini) were satellite tagged around the Saint Peter and Saint Paul Archipelago (SPSPA), located at the equatorial Mid-Atlantic ridge, to investigate their vertical and horizontal movements. All sharks remained in the surroundings of the SPSPA over the course of the 120-day monitoring period, suggesting a high degree of medium-term site fidelity. During this period, scalloped hammerhead sharks covered a wide extension of the water column, ranging from the mixed layer to the mesopelagic zone. All sharks remained in warm (>22°C) shallow layers most of the time, but also dove to depths greater than 150m, mostly at night, eventually reaching 728m (5.6°C) on two occasions. This study contributes important, novel information on the habitat use and movement patterns of scalloped hammerhead shark in Atlantic equatorial oceanic waters. It also highlights the potential of protecting key, large oceanic areas as a useful tool for the conservation of this endangered species.
Cl- channels regulate lipid droplet formation via Rab8a expression during adipocyte differentiation
Authors: Ouchi Kanae , Yoshie Susumu , Miyake Masao , Hazama Akihiro
Published: October 2019

Several studies have shown that Cl− channels regulate the differentiation of some cell types. Thus, we investigated the role of Cl− channels on adipocyte differentiation using adipose tissue-derived stem cells (ASCs) and Cl− channel blocker. We induced rabbit ASCs into adipocytes using Cl− channel blocker. The expression levels of adipocyte markers were no significant difference between the cells treated with a Cl− channel blocker NPPB and untreated cells. However, when the cells were treated with NPPB, lipid droplets (LDs) sizes decreased compared with the untreated control. Interestingly, the expression levels of Rab8a, which is known as a regulator of LD fusion, were also decreased in the cells treated with NPPB. Other Cl− channel blockers, DIDS and IAA-94, also inhibited large LDs formation and Rab8a expression. These results demonstrate that Cl− channels do not regulate the adipocyte differentiation, but do regulate the LDs formation via Rab8a expression.

Abbreviations: ASCs: adipose tissue-derived stem cells; LDs: lipid droplets; RUNX2: runt-related transcription factor 2; CFTR: cystic fibrosis transmembrane conductance regulator; TG: triacylglycerol; FA: fatty acid; GLUT4: glucose transporter type 4; ER: endoplasmic reticulum; ADRP: adipose differentiation-related protein; TIP47: tail-interacting protein of 47 kD; HSL: hormone sensitive lipase; PBS: phosphate-buffered saline; DMEM: Dulbecco’s modified Eagle Medium; FBS: fetal bovine serum; SMA: smooth muscle actin; FAS: fatty acid synthase; ZONAB: ZO-1 associated nucleic acid binding protein; PPAR-γ: peroxisome proliferator-activated receptor-γ; C/EBPα: CCAAT/enhancer binding protein α; CE: cholesteryl ester; V-ATPase: vacuolar H+ ATPase.
Preparing single SiV− center in nanodiamonds for external, optical coupling with access to all degrees of freedom
Authors: Häußler Stefan , Hartung Lukas , Fehler Konstantin G , Antoniuk Lukas , Kulikova Liudmila F , Davydov Valery A , Agafonov Viatcheslav N , Jelezko Fedor , Kubanek Alexander
Published: October 2019

Optical coupling enables intermediate- and long-range interactions between distant quantum emitters. Such interaction may be the basic element in bottom-up approaches of coupled spin systems or for integrated quantum photonics and quantum plasmonics. Here, we prepare nanodiamonds carrying single, negatively-charged silicon-vacancy centers for evanescent optical coupling with access to all degrees of freedom by means of atomic force nanomanipulation. The color centers feature excellent optical properties, comparable to silicon-vacancy centers in bulk diamond, resulting in a resolvable fine structure splitting, a linewidth close to the Fourier-Transform limit under resonant excitation and a good polarization contrast. We determine the orbital relaxation time T
1 of the orbitally split ground states and show that all optical properties are conserved during translational nanomanipulation. Furthermore, we demonstrate the rotation of the nanodiamonds. In contrast to the translational operation, the rotation leads to a change in polarization contrast. We utilize the change in polarization contrast before and after nanomanipulation to determine the rotation angle. Finally, we evaluate the likelihood for indistinguishable, single photon emission of silicon-vacancy centers located in different nanodiamonds. Our work enables ideal evanescent, optical coupling of distant nanodiamonds containing silicon-vacancy centers with applications in the realization of quantum networks, quantum repeaters or complex quantum systems.
Chemoprophylaxis Vaccination: Phase I Study to Explore Stage-specific Immunity to Plasmodium falciparum in US Adults
Authors: Healy Sara A , Murphy Sean C , Hume Jen C C , Shelton Lisa , Kuntz Steve , Van Voorhis Wesley C , Moodie Zoe , Metch Barbara , Wang Ruobing , Silver-Brace Tiffany , Fishbaugher Matthew , Kennedy Mark , Finney Olivia C , Chaturvedi Richa , Marcsisin Sean R , Hobbs Charlotte V , Warner-Lubin Margaret , Talley Angela K , Wong-Madden Sharon , Stuart Ken , Wald Anna , Kappe Stefan H , Kublin James G , Duffy Patrick E
Published: October 2019

Background

Chemoprophylaxis vaccination with sporozoites (CVac) with chloroquine induces protection against a homologous Plasmodium falciparum sporozoite (PfSPZ) challenge, but whether blood-stage parasite exposure is required for protection remains unclear. Chloroquine suppresses and clears blood-stage parasitemia, while other antimalarial drugs, such as primaquine, act against liver-stage parasites. Here, we evaluated CVac regimens using primaquine and/or chloroquine as the partner drug to discern whether blood-stage parasite exposure impacts protection against homologous controlled human malaria infection.

Methods

In a Phase I, randomized, partial double-blind, placebo-controlled study of 36 malaria-naive adults, all CVac subjects received chloroquine prophylaxis and bites from 12–15 P. falciparum–infected mosquitoes (CVac-chloroquine arm) at 3 monthly iterations, and some received postexposure primaquine (CVac-primaquine/chloroquine arm). Drug control subjects received primaquine, chloroquine, and uninfected mosquito bites. After a chloroquine washout, subjects, including treatment-naive infectivity controls, underwent homologous, PfSPZ controlled human malaria infection and were monitored for parasitemia for 21 days.

Results

No serious adverse events occurred. During CVac, all but 1 subject in the study remained blood-smear negative, while only 1 subject (primaquine/chloroquine arm) remained polymerase chain reaction–negative. Upon challenge, compared to infectivity controls, 3/3 chloroquine arm subjects displayed delayed patent parasitemia (P = .01) but not sterile protection, while 3/11 primaquine/chloroquine subjects remained blood-smear negative.

Conclusions

CVac-primaquine/chloroquine is safe and induces sterile immunity to P. falciparum in some recipients, but a single 45 mg dose of primaquine postexposure does not completely prevent blood-stage parasitemia. Unlike previous studies, CVac-chloroquine did not produce sterile immunity.

Clinical Trials Registration

NCT01500980.
MRI radiomic features are associated with survival in melanoma brain metastases treated with immune checkpoint inhibitors
Authors: Bhatia Ankush , Birger Maxwell , Veeraraghavan Harini , Um Hyemin , Tixier Florent , McKenney Anna Sophia , Cugliari Marina , Caviasco Annalise , Bialczak Angelica , Malani Rachna , Flynn Jessica , Zhang Zhigang , Yang T Jonathan , Santomasso Bianca D , Shoushtari Alexander N , Young Robert J
Published: October 2019

Background

Melanoma brain metastases historically portend a dismal prognosis, but recent advances in immune checkpoint inhibitors (ICIs) have been associated with durable responses in some patients. There are no validated imaging biomarkers associated with outcomes in patients with melanoma brain metastases receiving ICIs. We hypothesized that radiomic analysis of magnetic resonance images (MRIs) could identify higher-order features associated with survival.

Methods

Between 2010 and 2019, we retrospectively reviewed patients with melanoma brain metastases who received ICI. After volumes of interest were drawn, several texture and edge descriptors, including first-order, Haralick, Gabor, Sobel, and Laplacian of Gaussian (LoG) features were extracted. Progression was determined using Response Assessment in Neuro-Oncology Brain Metastases. Univariate Cox regression was performed for each radiomic feature with adjustment for multiple comparisons followed by Lasso regression and multivariate analysis.

Results

Eighty-eight patients with 196 total brain metastases were identified. Median age was 63.5 years (range, 19–91 y). Ninety percent of patients had Eastern Cooperative Oncology Group performance status of 0 or 1 and 35% had elevated lactate dehydrogenase. Sixty-three patients (72%) received ipilimumab, 11 patients (13%) received programmed cell death protein 1 blockade, and 14 patients (16%) received nivolumab plus ipilimumab. Multiple features were associated with increased overall survival (OS), and LoG edge features best explained the variation in outcome (hazard ratio: 0.68, P = 0.001). In multivariate analysis, a similar trend with LoG was seen, but no longer significant with OS. Findings were confirmed in an independent cohort.

Conclusion

Higher-order MRI radiomic features in patients with melanoma brain metastases receiving ICI were associated with a trend toward improved OS.
Discretionary policy and multiple equilibria in a new Keynesian model
Authors: Hahn Volker
Published: October 2019

We show that discretionary policymaking can lead to multiple rational-expectations equilibria where the central bank responds to inflation sentiments, which are driven by past endogenous variables but are unrelated to current economic fundamentals. Some of these equilibria have favourable consequences for welfare, resulting in outcomes superior even to those achieved under timeless-perspective commitment. Inflation sentiments also provide a novel explanation for the sizeable macroeconomic fluctuations in many countries in the 1970s. Compared to interest-rate rules violating the Taylor principle, our explanation has the advantage of providing a rationale for why central banks that are confronted with inefficiently large macroeconomic fluctuations may not be able to deviate to new policies with superior macroeconomic outcomes. Moreover, we show that our approach provides an alternative explanation for the high degree of inflation persistence found in the data.
DaxibotulinumtoxinA for Injection for the Treatment of Glabellar Lines: Results from Each of Two Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 3 Studies (SAKURA 1 and SAKURA 2)
Authors: Carruthers Jean D. , Fagien Steve , Joseph John H. , Humphrey Shannon D. , Biesman Brian S. , Gallagher Conor J. , Liu Yan , Rubio Roman G.
Published: October 2019

Background:

DaxibotulinumtoxinA for Injection (DAXI) is a novel botulinum toxin type A formulation in clinical development. A phase 2 dose-ranging study identified an optimal dose and demonstrated efficacy with a median duration of 24 weeks.

Methods:

In two phase 3, multicenter, randomized, double-blind, placebo-controlled studies (SAKURA 1 and SAKURA 2), subjects with moderate or severe glabellar lines at maximum frown were assigned randomly to receive placebo or 40 U of DAXI. Glabellar lines were evaluated at least every 4 weeks for at least 24 weeks until severity returned to baseline (≤36 weeks).

Results:

Overall, 609 subjects were enrolled (DAXI, n = 405; placebo, n = 204). DAXI was significantly more effective than placebo in achieving the primary efficacy outcome (≥2-point improvement in glabellar line severity at maximum frown at week 4 according to both investigator and subject ratings): 73.6 percent versus 0.0 percent (SAKURA 1), and 74.0 percent versus 1.0 percent (SAKURA 2) (both p < 0.0001). Composite investigator and subject ratings of maximum frown after DAXI treatment showed that glabellar line severity of none or mild was maintained for a median of 24.0 weeks (SAKURA 1) and 23.9 weeks (SAKURA 2), and glabellar line severity did not return to baseline levels for a median of 27.7 and 26.0 weeks, respectively. DAXI was generally well tolerated, with the most common adverse events related to DAXI treatment being headache (SAKURA 1, 7.0 percent; SAKURA 2, 5.9 percent) and injection-site pain (5.0 percent and 2.4 percent, respectively).

Conclusions:

Results from both studies were highly consistent. DAXI may offer a prolonged duration of response (median, ≥24 weeks) and is generally well tolerated.

CLINICAL QUESTION/LEVEL OF EVIDENCE:

Therapeutic, I.
“Metabolic contest”, a new way to control carbon source preference
Authors: Allmann Stefan , Wargnies Marion , Cahoreau Edern , Biran Marc , Plazolles Nicolas , Morand Pauline , Pineda Erika , Kulyk Hanna , Asencio Corinne , Villafraz Oriana , Rivière Loïc , Tétaud Emmanuel , Rotureau Brice , Mourier Arnaud , Portais Jean-Charles , Bringaud Frédéric
Published: October 2019

Microorganisms must make the right choice for nutrient consumption to adapt to their changing environment. As a consequence, bacteria and yeasts have developed regulatory mechanisms involving nutrient sensing and signaling, allowing to redirect cell metabolism to maximize the consumption of an energy-efficient carbon source. Here, we report a new mechanism, named “metabolic contest”, for regulating the use of carbon sources without nutrient sensing and signaling. In contrast to most microorganisms, trypanosomes show a glycerol-to-glucose preference that depends on the combination of three conditions: (i) the sequestration of both metabolic pathways in the same subcellular compartment, here in the peroxisomal-like organelles named glycosomes; (ii) the competition for the same substrate, here ATP, with the first enzymatic step of the glycerol and glucose metabolic pathways being both ATP-dependent (glycerol kinase and hexokinase, respectively) and (iii) an unbalanced activity between the competing enzymes, here the glycerol kinase activity being ~80-fold higher than the hexokinase activity.
An innovative citation recommendation model for draft papers with varying degrees of information completeness
Authors: Chen Yen-Liang , Weng Cheng-Hsiung , Huang Cheng-Kui , Shih Duo-Jia
Published: October 2019

Purpose

As researchers are writing a draft paper with incomplete structure or text, one of burdensome tasks is to deliberate about which references should be cited for one sentence or paragraph of this draft. In view of the rapid increase in the number of research papers, researchers desire to figure out a better way to do citation recommendations in developing their draft papers. The purpose of this paper is to propose citation recommendation algorithms that enable the acquisition of relevant citations for research papers that are still at the drafting stage. This study attempts to help researchers to select appropriate references among the vast amount of available papers and make draft papers complete in reference citation.

Design/methodology/approach

This study adopts a model for recommending citations for incomplete drafts. Four algorithms are proposed in this study. The first and second algorithms are unsupervised models, applying term frequency-inverse document frequency and WordNet technologies, respectively. The third and fourth algorithms are based on the second algorithm to integrate different weight adjustment strategies to improve performance.

Findings

The proposed recommendation method adopts three techniques, including using WordNet to transform vector and setting adjustment weights according to structural factors and the information completeness degree, to generate citation recommendation for incomplete drafts. The experiments show that all these three techniques can significantly improve the recommendation accuracy.

Originality/value

None of the methods employed in previous studies can recommend articles as references for incomplete drafts. This paper addresses the situation that a draft paper can be incomplete either in structure or text or both. Recommended references, however, can be still generated and inserted into any desired sentence of the draft paper.
Health-promoting initiatives in Saudi higher education
Authors: Alshehri Saad Zafir
Published: October 2019

Purpose

The purpose of this paper is to understand if effective road safety education is being provided to students by embedding educational programmes within a curriculum framework.

Design/methodology/approach

A qualitative methodology was used to gain in-depth understanding of the health-promoting initiatives of Saudi Arabian universities and colleges in preventing risky driving behaviour among students. Interviews were used to collect data from 11 faculty members.

Findings

Results suggest that educational programmes for changing the risky driving behaviour of students are still in their infancy. The findings raise questions about road safety and driving. While initiatives are being taken for promoting awareness within educational institutions on road safety, there is still a lack of awareness of traffic regulations and signs.

Originality/value

Since there is a paucity of research on health promotions specifically related to aberrant and risky driving in the Kingdom, this paper adds value to educators and policy-makers.
Social media in crisis communication – the “do’s” and “don’ts”
Authors: Maal Maren , Wilson-North Mark
Published: October 2019

Purpose

The use of social media in crisis communication is growing and spreading in an instantaneous speed. The social media technology enables immediate information sharing reaching millions of users on various social media platforms. This paper has gathered lessons learnt from the experiences of the Norfolk Fire and Rescue Service in the UK, the Oslo Police Operation Center in Norway, and from an extensive literature review on social media and crisis communication. This empirical and theoretical information was the basis of the 18 guidelines or “do’s” and “don’ts” on how to use social media in crisis communication. The purpose of this paper was to gather best practices that can help crisis managers when attempting to use social media as a crisis communication tool.

Design/methodology/approach

The paper had two cases with semi-structured interviews with representatives from two crisis management organizations (Norfolk Fire and Rescue Service in the UK dealing with safety and Oslo Police Operation Center in Norwa dealing with security). The empirical data were complemented by documentary analysis of the most up-to-date articles on social media in crisis communication.

Findings

The paper provides empirical insights about how to use social media as a crisis communication tool. The two case studies provide different ways to use social media (one-way communication tool and as a two-way information share). This empirical and theoretical information was the basis of the 18 guidelines or “do’s” and “don’ts” on how to use social media in crisis communication. The “do’s” and “don’ts” are best practices that can help crisis managers when attempting to use social media as a crisis communication tool. Some of the main “do’s” include building a relationship with the public prior to a crisis; being courteous, honest and transparent; being factual, accurate and credible; being timely in your messages during a crisis, etc. Some of the main “don’ts” include do not speculate; do not post personal opinions; do not post anything that could bring the organization into disrepute etc.

Research limitations/implications

Because of the chosen research approach with two case studies complemented by a literature review, the research results may lack generalizability. Therefore, researchers are encouraged to test the guidelines provided and to further find other case studies.

Practical implications

The guidelines including 18 “do’s” and “don’ts” are best practices that can help crisis managers when attempting to use social media as a crisis communication tool.

Originality/value

This paper fulfills an identified need to study how social media technology can play a major role in the response efforts of the crisis management community during a crisis. It also reveals the potential of using social media as an “information harvesting” tool and a tool for “rumor management”.
Non-linear effects of relational capital on supply-side resilience
Authors: Fan Yiyi , Stevenson Mark
Published: October 2019

Purpose

Prior studies have largely overlooked the potentially negative consequences of a buyer’s relational capital (RC) with a supplier for supply-side resilience, assuming a positive linear relationship between the constructs. Meanwhile, the focus of research has been at an organisational level without incorporating the role of boundary spanning individuals at the interface between buyer and supplier. Drawing on social capital and boundary spanning theory, the purpose of this paper is to: re-examine the relationship between RC and supply-side resilience, challenging the linear assumption; and investigate how both the strength and diversity of a boundary spanner’s ties moderate this relationship.

Design/methodology/approach

Survey data are collected from 248 firms and validated using a subset of 57 attentive secondary respondents and archival data. The latent moderated structural equation method is applied to analyse the data.

Findings

An inverted U-shaped relationship between RC and supply-side resilience is identified. Tie strength in particular has a positive moderating effect on the relationship. More specifically, the downward RC–supply-side resilience relationship flips into an upward curvilinear relationship when boundary spanning individuals develop stronger ties with supplier personnel.

Research limitations/implications

A deeper insight into the RC–supply-side resilience relationship is provided. Findings are based on Chinese manufacturing firms and cross-sectional data meaning further research is needed to determine their generalisability.

Practical implications

In evaluating how to enhance supply-side resilience, buying firms must decide whether the associated collaborative benefits of developing RC outweigh the potential costs. Managers also need to be concerned with the impact of developing RC between organisations and enhancing the tie strength of individuals simultaneously.

Originality/value

The paper goes beyond the linear relationship between RC and supply-side resilience. Incorporating the moderating role of boundary spanners identifies a novel phenomenon whereby the RC–resilience relationship flips from an inverted to a U-shaped curve.
Making sense of flipping data
Authors: Hart Simon , Nicholls Scott , Amos Howard , Benn Jill
Published: October 2019

Purpose

The purpose of this paper is to detail the approach used in a project that worked with journal publication, subscription and article processing charges (APC) data. The project aim was to test if the resources allocated by the Matariki Network of Universities, a group of seven medium-sized universities, would pay for APC at the current level of publishing activity.

Design/methodology/approach

Data were collated and analysed from three years (2015–2017) for each of the seven partners.

Findings

A range of assumptions were made in dealing with the data. It was difficult to identify a subscription package that was common to all the partners. Data were not always consistent and in some instances it was incomplete. An iterative and flexible approach was required in this project. Even though testing had been carried out during planning, changes had to be made as the project was carried out. The timetable had to be flexible as those working on the project dealt with their day-to-day operational priorities and to enable each of the partners to contribute as resources allowed.

Practical implications

As alternative models of scholarly journal publication are evolving, it is important that the implications of these be tested to inform planning. Details of this testing need to be shared so that others can confirm the results, consider the approach and apply lessons learned.

Originality/value

This paper focuses on the details of the investigation so that others interested in repeating this project, or carrying out a similar project, can consider this in their planning.
Islamic work ethics, organizational commitment and job satisfaction of Islamic banks in Indonesia
Authors: Nasution Fahmi Natigor , Rafiki Ahmad
Published: October 2019

Purpose

This study aims to examine the relationship of the Islamic work ethics, organizational commitment and job satisfaction of Muslim employees in the four Islamic commercial banks in Indonesia.

Design/methodology/approach

The study has adopted a quantitative method with descriptive and inferential statistical analysis. A stratified random sample of the executive management was taken, proportionate to the size of each organization. Out of a total of 250 distributed questionnaires, 220 respondents have responded. Frequencies and percentages were used to identify the characteristics of the respondents, while the preliminary data analysis of reliability and validity tests were used, along with the linear regression and the factor analysis of variance to answer the research question.

Findings

It found that the Islamic work ethics have a positive and significant relationship with organizational commitment and job satisfaction.

Originality/value

The sharia compliance requirement of Islamic banks is aligned with the Islamic work ethics’ principles and values, which thus could create in-depth organizational commitment among employees.
Use of interim execs as a nontraditional model
Authors: Fisher Mike
Published: October 2019

Purpose

The purpose of this article is to define the use of interim executives in the workplace.

Design/methodology/approach

A thought leadership approach is adopted for this article.

Findings

The article describes the common misconceptions, potential pitfalls and the benefits of hiring an interim executive.

Originality/value

At a time of changing work practices, economic and political uncertainty, organisations require help, without delay. This article offers an interim management solution as a way of assisting organisations to transform.
Filling efficiency of flip-chip underfill encapsulation process
Authors: Ng Fei Chong , Abas Mohamad Aizat , Abdullah Mohd Zulkifly
Published: October 2019

Purpose

This paper aims to introduce a new indicative parameter of filling efficiency to quantify the performance and productivity of the flip-chip underfill encapsulation process. Additionally, the variation effect of the bump pitch of flip-chip on the filling efficiency was demonstrated to provide insight for flip-chip design optimization.

Design/methodology/approach

The filling efficiency was formulated analytically based on the conceptual spatial and temporal perspectives. Subsequently, the effect of bump pitch on filling efficiency was studied based on the past actual-scaled and current scaled-up underfill experiments. The latter scaled-up experiment was validated with both the finite volume method-based numerical simulation and analytical filling time model. Moreover, the scaling validity of scaled-up experiment was justified based on the similarity analysis of dimensionless number.

Findings

Through the scaling analysis, the current scaled-up experimental system is justified to be valid since the adopted scaling factor 40 is less than the theoretical scaling limit of 270. Furthermore, the current experiment was qualitatively well validated with the numerical simulation and analytical filling time model. It is found that the filling efficiency increases with the bump pitch, such that doubling the bump pitch would triple the efficiency.

Practical implications

The new performance indicative index of filling efficiency enables the package designers to justify the variation effect of underfill parameter on the overall underfill process. Moreover, the upper limit of scaling factor for scaled-up package was derived to serve as the guideline for future scaled-up underfill experiments.

Originality/value

The performance of underfill process as highlighted in this paper was never being quantified before in the past literatures. Similarly, the scaling limit that is associated to the scaled-up underfill experiment was never being reported elsewhere too.
Optimisation of a guided endodontics protocol for removal of fibre‐reinforced posts
Authors: Perez Cyril , Finelle Gary , Couvrechel Cauris
Published: October 2019

This paper demonstrates the usefulness of endodontic guides for the removal of fibre posts. A 36‐year‐old man consulted for retreatment of a maxillary first molar presenting a periapical pathology. This tooth revealed a composite reconstruction together with a glass‐fibre post in the palatal root canal. To assist removal, use of an endodontic 3D‐printed guide was indicated. A cone beam computed tomography examination and an optical impression were made to produce a tooth‐supported guide by means of implant planning software (Blue Sky Plan, Blue Sky Bio®). The software enabled definition of a drilling pathway, which was transferred clinically using a resin template together with a sleeve and a 0.75‐mm drill. The drill was guided as far as the gutta‐percha situated in the apical third, limiting any risk of impairment or perforation.
Investigating the neural basis of cognitive control dysfunction in mood disorders
Authors: Breukelaar Isabella A. , Erlinger May , Harris Anthony , Boyce Philip , Hazell Philip , Grieve Stuart M. , Antees Cassandra , Foster Sheryl , Gomes Lavier , Williams Leanne M. , Malhi Gin S. , Korgaonkar Mayuresh S.
Published: October 2019

Objectives

Dysfunction of cognitive control is a feature of both bipolar disorder (BP) and major depression (MDD) and persists through to remission. However, it is unknown whether these disorders are characterized by common or distinct disruptions of cognitive control function and its neural basis. We investigated this gap in knowledge in asymptomatic BP and MDD participants, interpreted within a framework of normative function.

Methods

Participants underwent fMRI scans engaging cognitive control through a working memory task and completed a cognitive battery evaluating performance across multiple subdomains of cognitive control, including attention, impulsivity, processing speed, executive function, and memory. Analysis was performed in two stages: (i) cognitive control‐related brain activation and deactivation were correlated with cognitive control performance in 115 healthy controls (HCs), then, (ii) significantly correlated regions from (i) were compared between 25 asymptomatic BP, 25 remitted MDD, and with 25 different HCs, matched for age and gender.

Results

Impulsivity and executive function performance were significantly worse in BP compared to both MDD and HCs. Both BP and MDD had significantly poorer memory performance compared to HCs. Greater deactivation of the medial prefrontal cortex (MPFC) during the fMRI task was associated with better executive function in healthy controls. Significantly less deactivation in this region was present in both BP and MDD compared to HCs.

Conclusions

Failure to deactivate the MPFC, a key region of the default mode network, during working memory processing is a shared neural feature present in both bipolar and major depression and could be a source of common cognitive dysfunction.
A coloured polyester fabric with antimicrobial properties conferred by copper nanoparticles
Authors: Afshari Sepideh , Montazer Majid , Harifi Tina , Mahmoudi Rad Mahnaz
Published: October 2019

In this study, we aimed to produce a coloured polyester fabric through the in situ sonosynthesis of copper nanoparticles using copper sulphate, hydrazine, sodium hydroxide and polyvinylpyrrolidone. The treated fabrics were characterised by X‐ray diffraction, field emission scanning electron microscopy, energy‐dispersive X‐ray spectroscopy and elemental mapping. Moreover, mechanical properties, wettability and antibacterial/antifungal activities of the treated fabrics were evaluated. Central composite design based on the response surface methodology was used to study the effect of copper sulphate, hydrazine hydrate and sodium hydroxide on the weight gain and colour of the treated fabrics. In addition to their roles as reducing agents, hydrazine and sodium hydroxide were responsible for the simultaneous aminolysis and hydrolysis of polyester, increasing the adsorption of nanoparticles on the surface. According to the results, the reddish brown samples treated with copper nanoparticles showed excellent antibacterial and antifungal efficiencies, improved tensile strength and decreased wettability.
Influence of carrot fibre powder addition on rheological, microstructure and sensory characteristics of stirred‐type yogurt
Authors: Vénica Claudia I. , Spotti María J. , Pavón Yanina L. , Molli José S. , Perotti María C.
Published: October 2019

The incorporation of 1% (E1) and 2% (E2) of the carrot fibre powder obtained from carrot discards to yogurts was studied. The effect of the fibre addition on the physicochemical parameters, water‐holding capacity (WHC), microbial counts, rheological, microstructure and sensory characteristics of yogurts was studied in comparison with control yogurt without fibre addition (C). Titratable acidity, global composition and microbial counts showed a similar trend among yogurts. Fibre particles seemed to change the organisation of protein aggregates of the gel network. An open structure with bigger aggregates was observed in E1 and E2 yogurts, while the microstructure appeared more homogenous and without granules in C. However, carrot fibre increased the WHC of yogurt. All the yogurt samples exhibited shear‐thinning behaviour and no differences were found in the rheological parameters, excepting for E2 that presented a decrease in apparent viscosity at 200 s‐1 compared with C and E1 samples. Trained sensory panel (12 members) indicated an increase in brownish colour, strange flavour, grittiness and aftertaste and a decrease in overall appearance, odour, sweetness and creaminess in yogurts enriched in fibre. In order to mask these negative characteristics, E1 formulation was produced in the same way but strawberry flavour and colour were added. A consumer test (101 volunteers), purchase intention and a Check All That Apply (CATA) questionnaires were carried out. Flavoured and coloured E1 yogurt was pleasant for consumers, since 93% of the consumers selected positive degrees of acceptability and 68% of them manifested that they are willing to consume the product. Therefore, the addition of carrot fibre powder in yogurts could be an alternative to incorporate dietary fibres into dairy foods.
Enteral nutrition in critically ill adults: Literature review of protocols
Authors: Jordan Elizabeth A. , Moore Shelley C.
Published: October 2019

Background

Managing nutrition in critically ill patients is an important intervention to promote healing. It is unknown whether the implementation of a protocol that guides enteral nutrition (EN) support is effective in improving the outcomes of critically ill patients. Furthermore, it is unknown whether a nurse‐driven protocol is more or less effective than a protocol not managed by nurses.

Aims and objectives

The purpose of this literature review is to determine the current state of the science regarding evidence‐based protocols for the administration and management of EN in critically ill patients.

Search strategy, inclusion, and exclusion criteria

Studies were identified by searching the Cumulative Index to Nursing and Allied Health Literature Plus database for the terms “enteral nutrition AND nursing.” Studies with EN protocols for adult, critically ill patients published since 2011 were included. Studies without a protocol and those pertaining to paediatric, disease‐specific, medical‐surgical, or community‐based populations were excluded. A total of 10 studies meeting the inclusion criteria were identified.

Conclusions

Defining and implementing both early initiation of EN and adequate titration to goal are important for achieving the maximum nutritional advantage. The highest benefit is also derived from identifying and delivering an individualized caloric and/or protein goal. A protocol increases standardization of practice in relation to these themes as well as the management of gastric residual volume, complications, and potentially for managing feeding interruptions. Because of the significant effects of nursing care on nearly all aspects of the management and delivery of EN, a nurse‐driven protocol may yield higher compliance and greater effectiveness than a protocol that is not nurse driven.

Relevance to clinical practice

Nurses are at the forefront of EN administration, although interprofessional collaboration remains paramount. Current practice must align with the best practice in the development and implementation of an EN protocol.
Distribution of Parthenium hysterophorus and one of its biological control agents (Coleoptera: Zygogramma bicolorata) in Nepal
Authors: Shrestha B B , Pokhrel K , Paudel N , Poudel S , Shabbir A , Adkins S W
Published: October 2019

Parthenium hysterophorus is a noxious invasive weed of both agricultural and natural ecosystems, spreading aggressively in Nepal. Management of this weed in Nepal has been limited, mainly because of the lack of geo‐referenced data concerning the weed's distribution. We conducted a nationwide survey of P. hysterophorus and its coleopteran biological control agent Zygogramma bicolorata from 2013 to 2016 to determine their spatial distribution. Both were widespread, with the distribution of Z. bicolorata lagging behind the invasion front of P. hysterophorus. The weed was present in 21.2% of the 4838 locations examined, including several isolated satellite populations. The weed was found in the Tarai, Siwalik, Middle Mountains and High Mountains regions, reaching up to 2000 m asl. It has invaded natural and modified ecosystems including all six protected areas in the Tarai and Siwalik regions. Road access appears to be the major pathway for its long‐distance dispersal. Zygogramma bicolorata had spread from the east to the west and was present in 15.4% of the weed occurrence locations, inflicting a low amount of damage. A CLIMEX modelling projection revealed the presence of additional geographic areas in Nepal which are climatically suitable for both P. hysterophorus and Z. bicolorata. Eradication of satellite populations of the weed by physical and chemical measures, and the release of Z. bicolorata into new, but climatically suitable, locations should be prioritised for P. hysterophorus management in Nepal. In conclusion, P. hysterophorus has rapidly become widespread in Nepal and the currently available biological control agent has not been able to prevent further spread of the weed.
The Impact of Contextual Factors on Game Demands in Starting, Semiprofessional, Male Basketball Players
Authors: Fox Jordan L. , Stanton Robert , Sargent Charli , O’Grady Cody J. , Scanlan Aaron T.
Published: October 2019

Purpose: To quantify and compare external and internal game workloads according to contextual factors (game outcome, game location, and score-line). Methods: Starting semiprofessional, male basketball players were monitored during 19 games. External (PlayerLoad™ and inertial movement analysis variables) and internal (summated-heart-rate-zones and rating of perceived exertion [RPE]) workload variables were collected for all games. Linear mixed-effect models and effect sizes were used to compare workload variables based on each of the contextual variables assessed. Results: The number of jumps, absolute and relative (in min−1) high-intensity accelerations and decelerations, and relative changes-of-direction were higher during losses, whereas session RPE was higher during wins. PlayerLoad™ the number of absolute and relative jumps, high-intensity accelerations, absolute and relative total decelerations, total changes-of-direction, summated-heart-rate-zones, session RPE, and RPE were higher during away games, whereas the number of relative high-intensity jumps was higher during home games. PlayerLoad™, the number of high-intensity accelerations, total accelerations, absolute and relative decelerations, absolute and relative changes-of-direction, summated-heart-rate-zones, sRPE, and RPE were higher during balanced games, whereas the relative number of total and high-intensity jumps were higher during unbalanced games. Conclusions: Due to increased intensity, starting players may need additional recovery following losses. Given the increased external and internal workload volumes encountered during away games and balanced games, practitioners should closely monitor playing times during games. Monitoring playing times may help identify when players require additional recovery or reduced training volumes to avoid maladaptive responses across the in-season.
Lava lake thermal pattern classification using self-organizing maps and relationships to eruption processes at Kīlauea Volcano, Hawai‘i
Authors: Burzynski* A.M. , Anderson†§ S.W. , Morrison§ K. , Patrick§ M.R. , Orr§ T. , Thelen# W.
Published: October 2019

Kīlauea Volcano’s active summit lava lake posed hazards to downwind residents and over 1.6 million Hawai‘i Volcanoes National Park visitors each year during 2008–2018. The lava lake surface was dynamic; crustal plates separated by incandescent cracks moved across the lake as magma circulated below. We hypothesize that these dynamic thermal patterns were related to changes in other volcanic processes, such that sequences of thermal images may provide information about eruption parameters that are sometimes difficult to measure. The ability to learn about concurrent gas emissions and seismic activity from a remote thermal time-lapse camera would be beneficial when conditions are too hazardous for field measurements. We applied a machine learning algorithm called self-organizing maps (SOM) to thermal infrared time-lapse images of the lava lake collected hourly over 23 April–21 October 2013 (n= 4354). The SOM algorithm can take thousands of seemingly different images, each representing the spatial distribution of relative temperature across the lava lake surface, and group them into clusters based on their similarities. We then related the resulting clusters to sulfur dioxide emissions and seismic tremor activity to characterizeties between the SOM classification and different emplacement conditions. The SOM classification results are highly sensitive to the normalization method applied to the input images. The standard pixel-by-pixel normalization method yields a cluster of images defined by the highest observed SO2 emission levels, elevated surface temperatures, and a high proportion of cracks between crustal plates. When lava lake surface patterns are isolated by minimizing the effect of temperature variation between images, relationships with seismic tremor activity emerge, revealing an “intense spatter” cluster, characterized by unstable, broken-up crustal plate patterns on the lava lake surface. This proof of concept study provides a basis for extending the SOM classification method to hazard forecasting and real-time volcanic monitoring applications, as well as comparative studies at other lava lakes.