bluuebunny/crossref_metadata_2025 huggingface dataset:
Rivet Structural Design and Process Optimization for the Double-Sided Countersunk Riveting of Composite Wedge Structures
Authors: Qu Ligang , Li Peng , Lv Guangming , Li Jing , Luo Xian
Published: February 2024

Within the double-sided countersunk riveting process of aircraft wings with a composite wedge structure, riveting consistency is poor, and composite damage is severe, which seriously affects the performance and reliability of the aircraft structure. This paper used the principal stress method to establish a stress model of countersunk riveting, and, based on the analysis of the stress on the structure during the pressure-riveting process, a composite structure rivet was designed. A finite element simulation model of the double-sided countersunk riveting of composite wedge structures’ composite rivets was established. The influences of the structure and the matching parameters of composite rivets on both the plastic flow of pressure riveting and the compressive stress of the structure during the pressure-riveting process were analyzed. The structural parameters and riveting process of composite rivets were optimized. The results show that the composite rivet structure could significantly reduce the contact-compressive stress at the riveting joint by more than 20%, thereby reducing the damage caused by the riveting to the composite material. For 4 mm rivets, an aperture of 4.04~4.06 mm can achieve precise relative interference riveting at 0.6% to 1.0%. Employing a 2.6 mm rivet elongation can exactly fill the countersunk hole of the wedge.
Near Real-Time Remote Sensing Based on Satellite Internet: Architectures, Key Techniques, and Experimental Progress
Authors: Zhang Peng , Qin Qin , Zhang Shijie , Zhao Xiangtian , Yan Xiaoliang , Wang Wei , Zhang Hongbin
Published: February 2024

Remote sensing has become an essential tool for geological exploration, disaster monitoring, emergency rescue, and environmental supervision, while the limited number of remote sensing satellites and ground stations restricts the timeliness of remote sensing services. Satellite Internet has features of large bandwidth, low latency, and wide coverage, which can provide ubiquitous high-speed access for time-sensitive remote sensing users. This study proposes a near real-time remote sensing (NRRS) architecture, which allows satellites to transmit remote sensing data via inter-satellite links and offload to the Earth Stations from the satellite that moves overhead. The NRRS architecture has the advantages of instant response, ubiquitous access, and intelligent integration. Based on a test communication constellation, a vehicle-mounted Satcom on-the-move experiment was conducted to validate the presented NRRS architecture. The results show that the whole process from demand collection to image acquisition takes no more than 25 min, which provides an engineering reference for the subsequent implementation of near real-time remote sensing.
Vibrational Dynamics of Rice Precision Hole Seeders and Their Impact on Seed Dispensation Efficacy
Authors: Yu Dongyang , Peng Feihu , Zeng Zhihao , Zhang Minghua , Yang Wenwu , Zang Ying , He Jianfei , Huang Yichen , Wu Yuguang , Zhong Wenneng , Guo Ziyou , Liu Jiawen , Li Guanjiong , Qin Xingmou , Wang Zaiman
Published: February 2024

This investigation considered the effects of both internal and external excitation vibrations on the efficacy of the seed dispenser in a rice precision hole seeder. Through comprehensive field tests, we analyzed vibrational characteristics during direct seeder operations and established a vibration seeding test bed for systematic examination of these effects. Time-domain analysis of the vibration data revealed a predominantly vertical vibration direction, with notably higher levels in sandy loam soil compared to clay loam. A correlation was observed between increased engine size and rotary ploughing speeds, as well as forward speed and elevated vibration amplitudes. Frequency domain analysis pinpointed the primary vibration frequency of the machinery within the 0–170 Hz range, remaining consistent across different operating conditions. Crucially, bench test results indicated that seeding accuracy and dispersion were significantly influenced by vibration frequencies, particularly within the 70–130 Hz range, where a decrease in accuracy and increase in dispersion were noted. A regression model suggested a complex, non-linear relationship between seeding performance and vibration frequency. These insights highlight the necessity for a robust mechanism to effectively address these vibrational impacts. This study paves the way for enhancing the operational efficiency of the rice precision hole seeder, aiming to achieve the design goals of minimized vibrations in the paddy power chassis.
Effect of Genotype, Environment, and Their Interaction on the Antioxidant Properties of Durum Wheat: Impact of Nitrogen Fertilization and Sowing Time
Authors: Melios Stergios , Ninou Elissavet , Irakli Maria , Tsivelika Nektaria , Sistanis Iosif , Papathanasiou Fokion , Didos Spyros , Zinoviadou Kyriaki , Karantonis Haralabos Christos , Argiriou Anagnostis , Mylonas Ioannis
Published: February 2024

In this study, the influence of genotype (G), environment (E), and their interaction (G × E) on the content of total free phenolic compounds (TPC) and the antioxidant capacity (AC) was investigated, using sixteen durum wheat genotypes cultivated under seven crop management systems in Mediterranean environments. Possible correlations between TPC and AC with protein content (PC) and vitreous kernel percentage (VKP) were examined. Gs that exhibited stability across diverse conditions were studied through a comprehensive exploration of G × E interaction using a GGE biplot, Pi, and 𝘒R. The results indicated significant impacts of E, G, and G × E on both TPC and AC. Across E, the mean values of G for TPC, ABTS (2’-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid), DPPH (2,2-diphenyl-1-picrylhydrazyl), and FRAP (ferric reducing antioxidant power) values were 48.8 mg Trolox equivalents (TE)/100 g, 121.3 mg TE/100 g, 23.0 mg TE/100 g, and 88.4 mg TE/100 g, respectively. E, subjected to splitting top-dressing N fertilization, consistently showed low values, while the late-sowing ones possessed high values. Organic crop management maintained a stable position in the middle across all measurements. The predominant influence was attributed to G × E, as indicated by the order G × E > E > G for ABTS, DPPH, and FRAP, while for TPC, it was E > G × E > G. For TPC, the superior Gs included G5, G7 and G10, for ABTS included G3, G5 and G7, and for protein included G1, G9, and G16. G7 and G5 had a high presence of frequency, with G7 being the closest genotype to the ideal for both TPC and ABTS. These results suggest that the sowing time, nitrogen fertilization, and application method significantly impact the various antioxidant properties of durum wheat. This study holds significant importance as it represents one of the few comprehensive explorations of the impact of various Es, Gs, and their interactions on the TPC and AC in durum wheat, with a special emphasis on crop management and superior Gs possessing stable and high TPC and AC among them, explored by GGE biplot, Pi and 𝘒R. Further experimentation, considering the effect of the cultivation year, is necessary, to establish more robust and stable conclusions.
Phenylalanine Ammonia-Lyase-Mediated Differential Response of Tomato (Solanum lycopersicum L.) Cultivars with Different Stress Tolerance to Treatment with Low-Molecular-Weight Chitosan
Authors: Timofeeva Tatiana A. , Bubnova Anastasiya N. , Shagdarova Balzhima T. , Varlamov Valery P. , Kamionskaya Anastasiya M.
Published: February 2024

The latest research has shown that chitosan acts as a growth stimulator and elicitor in plants, including resistance to biotic and abiotic factors. However, increasing concentrations could possibly make chitosan a source of stress for plants. In this study, we investigated the effect of low-molecular-weight chitosan hydrolysate on the root development of tomato (Solanum lycoperscum) cultivars Red Cherry, Lel, and Tytan. The growth rate change, together with total phenolic content, phenylalanine ammonia-lyase (PAL) activity, and gene expression, were studied in relation to tomatoes. High concentrations of chitosan negatively affect the growth of tomato seedlings and contribute to changes in the tropism of the seedling roots. After the addition of chitosan hydrolysate, the PAL activity and the total phenolic content decreased 24 h later. PAL is a key enzyme in the biosynthesis of many plant stress factors. An analysis of the tomato PAL gene family was carried out. The SlPAL gene expression in the seedlings of cv. Cherry increased 1.5 times after 48 h, while in cv. Lel, the expression stably decreased in the presence of chitosan. The obtained results are supposed to aid our understanding of the mechanisms underlying the effects of chitosan on plant development and further its successful application in agriculture as well as in research on plant stress.
Impact of Reactive Sulfur Species on Entamoeba histolytica: Modulating Viability, Motility, and Biofilm Degradation Capacity
Authors: Ye Jun , Salti Talal , Zanditenas Eva , Trebicz-Geffen Meirav , Benhar Moran , Ankri Serge
Published: February 2024

Reactive sulfur species (RSS) like hydrogen sulfide (H2S) and cysteine persulfide (Cys-SSH) emerged as key signaling molecules with diverse physiological roles in the body, depending on their concentration and the cellular environment. While it is known that H2S and Cys-SSH are produced by both colonocytes and by the gut microbiota through sulfur metabolism, it remains unknown how these RSS affect amebiasis caused by Entamoeba histolytica, a parasitic protozoan that can be present in the human gastrointestinal tract. This study investigates H2S and Cys-SSH’s impact on E. histolytica physiology and explores potential therapeutic implications. Exposing trophozoites to the H2S donor, sodium sulfide (Na2S), or to Cys-SSH led to rapid cytotoxicity. A proteomic analysis of Cys-SSH-challenged trophozoites resulted in the identification of >500 S-sulfurated proteins, which are involved in diverse cellular processes. Functional assessments revealed inhibited protein synthesis, altered cytoskeletal dynamics, and reduced motility in trophozoites treated with Cys-SSH. Notably, cysteine proteases (CPs) were significantly inhibited by S-sulfuration, affecting their bacterial biofilm degradation capacity. Immunofluorescence microscopy confirmed alterations in actin dynamics, corroborating the proteomic findings. Thus, our study reveals how RSS perturbs critical cellular functions in E. histolytica, potentially influencing its pathogenicity and interactions within the gut microbiota. Understanding these molecular mechanisms offers novel insights into amebiasis pathogenesis and unveils potential therapeutic avenues targeting RSS-mediated modifications in parasitic infections.
Deep Learning-Based Vehicle Type and Color Classification to Support Safe Autonomous Driving
Authors: Kim JongBae
Published: February 2024

This technology can prevent accidents involving large vehicles, such as trucks or buses, by selecting an optimal driving lane for safe autonomous driving. This paper proposes a method for detecting forward-driving vehicles within road images obtained from a vehicle’s DashCam. The proposed method also classifies the types and colors of the detected vehicles. The proposed method uses a YOLO deep learning network for vehicle detection based on a pre-trained ResNet-50 convolutional neural network. Additionally, a Resnet-50 CNN-based object classifier, using transfer learning, was used to classify vehicle types and colors. Vehicle types were classified into four categories based on size whereas vehicle colors were classified into eight categories. During autonomous driving, vehicle types are used to determine driving lanes, whereas vehicle colors are used to distinguish the road infrastructure, such as lanes, vehicles, roads, backgrounds, and buildings. The datasets used for learning consisted of road images acquired in various driving environments. The proposed method achieved a vehicle detection accuracy of 91.5%, vehicle type classification accuracy of 93.9%, and vehicle color classification accuracy of 94.2%. It accurately detected vehicles and classified their types and colors. These can be applied to autonomous and safe driving support systems to enhance the safety of autonomous vehicles.
Nonlinear Semi-Numeric and Finite Element Analysis of Three-Point Bending Tests of Notched Polymer Fiber-Reinforced Concrete Prisms
Authors: Unuk Žiga , Kuhta Milan
Published: February 2024

A nonlinear semi-numeric and finite element analysis of three-point bending tests of notched polymer fiber-reinforced concrete prisms was performed. The computational and experimental results were compared in terms of the load-displacement behavior. The vertical midspan displacement and the crack mouth opening displacement results were considered. The nonlinear semi-numeric computational procedure involved the moment-curvature relation, calculated by considering the constitutive material law from the fib Model Code for Concrete Structures 2010, and considered a plastic hinge mechanism to simulate the cracked region behavior. Two sets of tensile mechanical properties were considered for the constitutive material law: back-calculated (by an inverse analysis) tensile strength properties from the experimental results, and tensile strength properties calculated by simplified expressions from the fib Model Code for Concrete Structures 2010. Other mechanical properties were determined by additional compressive tests and standard relations for the dependency of various mechanical properties on the concrete compressive strength. The nonlinear finite element analysis incorporated the Menetrey-Willam material model to simulate the fiber-reinforced concrete behavior. The nonlinear semi-numeric analysis load-displacement results based on the back-calculated tensile strength properties relatively accurately matched with the experimental results, whereas the nonlinear semi-numeric analysis load-displacement results based on tensile strength properties calculated by simplified expressions from the fib Model Code for Concrete Structures 2010 and the nonlinear finite element analysis load-displacement results showed certain shortcomings.
Study on the Self–Bearing Mechanism and Mechanical Properties of Gangue Slurry under Overburden Loading
Authors: Liu Sixu , Xu Jianfei , Zhou Nan , Zhang Yuzhe , Dong Chaowei , Lv Zhuo
Published: February 2024

The mining of coal resources is accompanied by a large amount of solid waste such as gangue, which seriously affects the ecological environment. The gangue grouting backfilling technique can achieve the dual goals of gangue disposal and surface deformation control by injecting gangue slurry into the underground. The bearing mechanical characteristics of gangue slurry directly affect the surface deformation control effect of the grouting backfilling technique. In this study, a loading simulation system of grouting backfilling materials was designed, uniaxial confined compression tests were conducted, and the self–bearing mechanism of large particle–sized gangue slurry with different fluidities under instantaneous and creep loading modes was investigated. Additionally, the mechanical characteristics of the compacted body (i.e., the gangue slurry after creep loading) were analyzed. The results indicate that the self–bearing process of gangue slurry can be divided into three stages: the rapid compression and drainage stage, the pore compaction and water bleeding stage, and the particle crushing and elastic–plastic deformation stage. The uniaxial compressive stress–strain curve of a compacted body can be classified into four stages: elastic stage, yield stage, reinforcement stage, and crushing stage, and the strength of the compacted body is affected by the loading time and fluidity of the slurry. When the slurry with a fluidity of 240 mm is subjected to constant pressure for 3 h, the compressive strength of the slurry reaches the maximum value of 4.98 MPa, and 13.1% stress damage occurs when the constant pressure reaches 4 h. This research provides a theoretical basis for the improvement of the proportion and bearing characteristics of gangue grouting materials.
Landslide Detection Based on Multi-Direction Phase Gradient Stacking, with Application to Zhouqu, China
Authors: Xiong Tao , Sun Qian , Hu Jun
Published: February 2024

Landslides are a common geological disaster, which cause many economic losses and casualties in the world each year. Drawing up a landslide list and monitoring their deformations is crucial to prevent landslide disasters. Interferometric synthetic aperture radar (InSAR) can obtain millimeter-level surface deformations and provide data support for landslide deformation monitoring. However, some landslides are difficult to detect due to the low-coherence caused by vegetation cover in mountainous areas and the difficulty of phase unwrapping caused by large landslide deformations. In this paper, a method based on multi-direction phase gradient stacking is proposed. It employs the differential interferograms of small baseline sets to directly obtain the abnormal region, thereby avoiding the problem where part of landslide cannot be detected due to a phase unwrapping error. In this study, the Sentinel-1 satellite ascending and descending data from 2018 to 2020 are used to detect landslides around Zhouqu County, China. A total of 26 active landslides were detected in ascending data and 32 active landslides in the descending data using the method in this paper, while the SBAS-InSAR detected 19 active landslides in the ascending data and 25 active landslides in the descending data. The method in this paper can successfully detect landslides in areas that are difficult for the SBAS-InSAR to detect. In addition, the proposed method does not require phase unwrapping, so a significant amount of data processing time can be saved.
Evaluation of Tooth Movement Accuracy with the F22 Aligner System: A Retrospective Study
Authors: Mario Palone , de Villagomez Silvia Squeo , Federica Pellitteri , Cremonini Francesca , Salvatore Renato , Lombardo Luca
Published: February 2024

Background: To investigate the accuracy of an F22 Aligner system, considering the amount of prescribed movement, tooth type, grip points, sex and age. Methods: Digital models of 120 patients (64 females and 56 males; mean age 35.2 years ± 7.4) affected by mild-to-moderate Class I malocclusion and treated via F22 Aligners, retrospectively selected from the University of Ferrara Orthodontics Clinic’s electronic database; post-treatment models were generated, and three angular values per tooth and four linear intra-arch measurements per arch were acquired. For angular measurements, planned (T1) and achieved (T2) values were obtained thorough digital model superimpositions. Linear measurements were acquired from pre-treatment, reference and post-treatment models. Statistical comparisons were performed to assess accuracy among tooth types and prescribed movements, tooth type, grip points, sex and age were investigated via chi-squared automatic interaction detection regression trees. Results: Mean accuracy for inclination and angulation were 86.76% and 88.01%, respectively, whereas rotation was less accurate (61.59%), especially for rounded teeth. All variables investigated influenced accuracy, with the exception of inclination, which was only influenced by age. Regarding linear measurements, good expansive capacity was shown, except for the distance between mandibular second premolars. Conclusions: F22 aligners are a viable solution for the treatment of Class I malocclusion of mild-to-moderate complexity, although clinicians should bear in mind the lower predictability of rotation, as well as the influence of the variables investigated.
A Long-Term Split-Mouth Randomized Controlled Trial to Assess Implant Treatment Outcome Using Implants with a Different Surface Roughness
Authors: Glibert Maarten , Matthys Carine , Van Lancker Aurélie , Segers Amber , De Bruyn Hugo
Published: February 2024

The influence of implant surface roughness on implant treatment outcome is still under debate. A rougher implant surface improves osseointegration but yields greater plaque accumulation and biofilm formation. Hybrid implants have a minimally rough component coronally and a moderately rough implant body. The aim of this split-mouth study is to evaluate the long-term outcome of treatment with hybrid and moderately rough implants after 6 years. As a secondary aim, Oral Health Quality of Life (OHQoL) was assessed after one and six years. Fully edentulous patients received an overdenture supported by two implants. One implant had a hybrid surface (MSC) and one implant had a moderately rough surface (DCC). Radiographic crestal bone loss (CBL), plaque score, bleeding on probing (BoP) and periodontal probing depth (PPD) were determined at one and six years. OHQoL was evaluated using the Oral Health Impact Profile-14 (OHIP-14) questionnaire and a Visual Analogue Scale (VAS). Twenty-one patients with 42 implants were evaluated after 6 years. No implants failed and a mean CBL of 0.26 mm (SD: 0.42) for the MSC group and 0.17 mm (SD: 0.29) for the DCC group was observed, which was not statistically significant. Periodontal parameters were comparable after 6 years and a significant improvement in OHQoL was observed. This randomized controlled trial concludes that hybrid implants are a predictable treatment alternative for moderately rough implants in patients with an overdenture supported by two implants.
Effects of Pipe Deflection and Arching on Stress Distribution and Lateral Earth Pressure Coefficient in Buried Flexible Pipes
Authors: Gulen Murat , Kilic Havvanur
Published: February 2024

In this study, full-scale laboratory tests were conducted on a 315 mm diameter HDPE pipe under shallow buried and localised surface loading conditions to investigate the effects of pipe deflection and arching on stress distribution and the lateral earth pressure coefficient. The tests were validated using 2D finite element software, and further analyses were carried out through parametric studies. These studies considered variations in pipe stiffness, burial depth, backfill properties and pavement stiffness to increase the reliability of the test results. For a shallowly buried HDPE pipe, a comprehensive explanation is provided regarding the evolution of the lateral earth pressure coefficient within the central soil prism. Initially set at Ko conditions, this coefficient tends to shift towards Kp with increasing arching and transitions to Ka with weakening arching. The findings suggest that stress predictions in the crown region of shallow buried flexible pipes are achievable through the application of Terzaghi’s arching theory, contingent upon an accurate estimation of the lateral earth pressure coefficient for the central soil prism. Furthermore, the horizontal deflection of the pipe at the springline results in compressive behaviour and passive effects in the surrounding backfill in this specific region. This situation demonstrates that the horizontal stresses at the springline and the lateral earth pressure coefficient can be reliably estimated by considering them as functions of the horizontal deflection of the pipe.
Arts and Refugees: Multidisciplinary Perspectives (Vol. 2)
Authors: Martiniello Marco , Mescoli Elsa
Published: February 2024

Published in 2019, the Special Issue entitled “Arts and Refugees: Multidisciplinary Perspectives” gathered together a set of articles exploring the role of art created and performed by refugees settled in urban European contexts [...]
On the Exact Solution of a Scalar Differential Equation via a Simple Analytical Approach
Authors: Alshomrani Nada A. M. , Ebaid Abdelhalim , Aldosari Faten , Aljoufi Mona D.
Published: February 2024

The existence of the advance parameter in a scalar differential equation prevents the application of the well-known standard methods used for solving classical ordinary differential equations. A simple procedure is introduced in this paper to remove the advance parameter from a special kind of first-order scalar differential equation. The suggested approach transforms the given first-order scalar differential equation to an equivalent second-order ordinary differential equation (ODE) without the advance parameter. Using this method, we are able to construct the exact solution of both the transformed model and the given original model. The exact solution is obtained in a wave form with specified amplitude and phase. Furthermore, several special cases are investigated at certain values/relationships of the involved parameters. It is shown that the exact solution in the absence of the advance parameter reduces to the corresponding solution in the literature. In addition, it is declared that the current model enjoys various kinds of solutions, such as constant solutions, polynomial solutions, and periodic solutions under certain constraints of the included parameters.
An Algorithm Based on Compute Unified Device Architecture for Estimating Covering Functionals of Convex Bodies
Authors: Han Xiangyang , Wu Senlin , Zhang Longzhen
Published: February 2024

In Chuanming Zong’s program to attack Hadwiger’s covering conjecture, which is a longstanding open problem from Convex and Discrete Geometry, it is essential to estimate covering functionals of convex bodies effectively. Recently, He et al. and Yu et al. provided two deterministic global optimization algorithms having high computational complexity for this purpose. Since satisfactory estimations of covering functionals will be sufficient in Zong’s program, we propose a stochastic global optimization algorithm based on CUDA and provide an error estimation for the algorithm. The accuracy of our algorithm is tested by comparing numerical and exact values of covering functionals of convex bodies including the Euclidean unit disc, the three-dimensional Euclidean unit ball, the regular tetrahedron, and the regular octahedron. We also present estimations of covering functionals for the regular dodecahedron and the regular icosahedron.
Concurrent Learning Approach for Estimation of Pelvic Tilt from Anterior–Posterior Radiograph
Authors: Jodeiri Ata , Seyedarabi Hadi , Danishvar Sebelan , Shafiei Seyyed Hossein , Sales Jafar Ganjpour , Khoori Moein , Rahimi Shakiba , Mortazavi Seyed Mohammad Javad
Published: February 2024

Accurate and reliable estimation of the pelvic tilt is one of the essential pre-planning factors for total hip arthroplasty to prevent common post-operative complications such as implant impingement and dislocation. Inspired by the latest advances in deep learning-based systems, our focus in this paper has been to present an innovative and accurate method for estimating the functional pelvic tilt (PT) from a standing anterior–posterior (AP) radiography image. We introduce an encoder–decoder-style network based on a concurrent learning approach called VGG-UNET (VGG embedded in U-NET), where a deep fully convolutional network known as VGG is embedded at the encoder part of an image segmentation network, i.e., U-NET. In the bottleneck of the VGG-UNET, in addition to the decoder path, we use another path utilizing light-weight convolutional and fully connected layers to combine all extracted feature maps from the final convolution layer of VGG and thus regress PT. In the test phase, we exclude the decoder path and consider only a single target task i.e., PT estimation. The absolute errors obtained using VGG-UNET, VGG, and Mask R-CNN are 3.04 ± 2.49, 3.92 ± 2.92, and 4.97 ± 3.87, respectively. It is observed that the VGG-UNET leads to a more accurate prediction with a lower standard deviation (STD). Our experimental results demonstrate that the proposed multi-task network leads to a significantly improved performance compared to the best-reported results based on cascaded networks.
Bacterial Flora in Screw-Fixed Superstructures with Different Sealing Materials: A Comparative Clinical Trial
Authors: Yamaguchi Kikue , Munakata Motohiro , Ishii Kota , Uesugi Takashi
Published: February 2024

A screw-fixed superstructure is predominantly selected for implant prostheses because of the concern regarding developing peri-implantitis, although its infection route remains unclear. Focusing on microleakage from access holes, the present study clinically investigated the bacterial flora in access holes with different sealing materials. We examined 38 sites in 19 patients with two adjacent screw-fixed superstructures. Composite resin was used in the control group, and zinc-containing glass ionomer cement was used in the test group. Bacteria were collected from the access holes 28 days after superstructure placement and were subjected to DNA hybridization analysis. The same patient comparisons of the bacterial counts showed a significant decrease in 14 bacterial species for the red, yellow, and purple complexes in the test group (p < 0.05). In addition, the same patient comparisons of the bacterial ratios showed a significant decrease in six bacterial species for the orange, green, yellow, and purple complexes in the test group (p < 0.05). Furthermore, the same patient comparisons of the implant positivity rates showed a significant decrease in the six bacterial species for the orange, yellow, and purple complexes in the test group. The results of this study indicate that zinc-containing glass ionomer cement is effective as a sealing material for access holes.
The Comparative Effect of Occupational and Musical Enrichment on Fecal Glucocorticoid Metabolite Levels in a Captive Colony of Stumptail Macaques (Macaca arctoides)
Authors: Mayagoitia-Novales Lilian , Cerda-Molina Ana Lilia , Martín-Guerrero María Andrea , Muñoz-Zamudio Emmanuel , Estudillo-Mendoza Gema R. , Borráz-León Javier I.
Published: February 2024

Environmental enrichment improves captive animal welfare by reducing stress-related behaviors. Previous studies in a captive colony of stumptail macaques (Macaca arctoides) reported a reduction of aggression, coprophilia, and stereotypic behaviors after an occupational enrichment program; however, the effect on stress hormones such as glucocorticoids has not been investigated yet. The goal of this study was to compare the effect of sex, age, and social rank on changes in fecal glucocorticoid metabolites (fGCM) after applying two kinds of enrichments (occupational vs. musical) in a captive colony of stumptail macaques. We collected 234 fecal samples from 25 stumptail macaques under the following conditions: (1) basal (no enrichment), (2) three weeks of occupational enrichment, and (3) three weeks of relaxing/classical music. The Generalized Estimated Equation Model showed an increase in fGCM levels after the occupational enrichment only in adult subjects (p = 0.003 compared to basal). The fGCM levels reached by the adults after the occupational enrichment was higher than that of juveniles (p = 0.002) and subadults (p = 0.02). Occupational and musical enrichment decreased fGCM levels only in middle-ranking individuals (p < 0.001 and p = 0.013, respectively). No sex differences were found. In conclusion, there were age and rank differences in individuals’ physiological reactivity to the effects of environmental enrichment which need to be considered when planning enrichment programs.
The Role of Bcl11 Transcription Factors in Neurodevelopmental Disorders
Authors: Seigfried Franziska Anna , Britsch Stefan
Published: February 2024

Neurodevelopmental disorders (NDDs) comprise a diverse group of diseases, including developmental delay, autism spectrum disorder (ASD), intellectual disability (ID), and attention-deficit/hyperactivity disorder (ADHD). NDDs are caused by aberrant brain development due to genetic and environmental factors. To establish specific and curative therapeutic approaches, it is indispensable to gain precise mechanistic insight into the cellular and molecular pathogenesis of NDDs. Mutations of BCL11A and BCL11B, two closely related, ultra-conserved zinc-finger transcription factors, were recently reported to be associated with NDDs, including developmental delay, ASD, and ID, as well as morphogenic defects such as cerebellar hypoplasia. In mice, Bcl11 transcription factors are well known to orchestrate various cellular processes during brain development, for example, neural progenitor cell proliferation, neuronal migration, and the differentiation as well as integration of neurons into functional circuits. Developmental defects observed in both, mice and humans display striking similarities, suggesting Bcl11 knockout mice provide excellent models for analyzing human disease. This review offers a comprehensive overview of the cellular and molecular functions of Bcl11a and b and links experimental research to the corresponding NDDs observed in humans. Moreover, it outlines trajectories for future translational research that may help to better understand the molecular basis of Bcl11-dependent NDDs as well as to conceive disease-specific therapeutic approaches.
The Reign of Follistatin in Tumors and Their Microenvironment: Implications for Drug Resistance
Authors: Sosa Jennifer , Oyelakin Akinsola , Sinha Satrajit
Published: February 2024

Follistatin (FST) is a potent neutralizer of the transforming growth factor-β superfamily and is associated with normal cellular programs and various hallmarks of cancer, such as proliferation, migration, angiogenesis, and immune evasion. The aberrant expression of FST by solid tumors is a well-documented observation, yet how FST influences tumor progression and therapy response remains unclear. The recent surge in omics data has revealed new insights into the molecular foundation underpinning tumor heterogeneity and its microenvironment, offering novel precision medicine-based opportunities to combat cancer. In this review, we discuss these recent FST-centric studies, thereby offering an updated perspective on the protean role of FST isoforms in shaping the complex cellular ecosystem of tumors and in mediating drug resistance.
Comparative Study of Lesions Obtained through Radiofrequency between the Irrigated Ablation Catheter with a Flexible Tip and the Non-Irrigated Catheter in Ex Vivo Porcine Hearts
Authors: Vitali Francesco , De Raffele Martina , Malagù Michele , Balla Cristina , Azzolini Giorgia , Gibiino Federico , Boccadoro Alberto , Micillo Marco , Bertini Matteo
Published: February 2024

Background: At the same conditions of delivered power and contact force, open-irrigated radiofrequency ablation catheters are believed to create deeper lesions, while non-irrigated ones produce shallower lesions. This ex vivo study aims to directly compare the lesion dimensions and characteristics of an irrigated ablation catheter with a flexible tip and a non-irrigated solid-tip catheter. Methods: Radiofrequency lesions were induced on porcine myocardial slabs using both open-tip irrigated and non-irrigated standard 4 mm catheters at three power settings (20 W, 30 W, and 40 W), maintaining a fixed contact force of 10 gr. A lesion assessment was conducted including the lesion depth, depth at the maximum diameter, and lesion surface diameters, with the subsequent calculation of the lesion volume and area being undertaken. Results: Irrigated catheters produced lesions with significantly higher superficial widths at all power levels (3.8 vs. 4.4 mm at 20 W; 3.9 mm vs. 4.4 mm at 30 W; 3.8 mm vs. 4.5 mm at 40 W; p = 0.001, p = 0.019, p = 0.003, respectively). Non-irrigated catheters resulted in significantly higher superficial areas at all power levels (23 mm2 vs. 18 mm2 at 20 W; 25 mm2 vs. 19 mm2 at 30 W; 26 mm2 vs. 19 mm2 at 40 W; p = 0.001, p = 0.005, p = 0.001, respectively). Irrigated catheters showed significantly higher values of lesion maximum depth at 40 W (4.6 mm vs. 5.5 mm; p = 0.007), while non-irrigated catheters had a significantly higher calculated volume at 20 W (202 µL vs. 134 µL; p = 0.002). Conclusions: Radiofrequency ablation using an irrigated catheter with a flexible tip has the potential to generate smaller superficial lesion areas compared with those obtained using a non-irrigated catheter.
A New Approach Based on Collective Intelligence to Solve Traveling Salesman Problems
Authors: Kiran Mustafa Servet , Beskirli Mehmet
Published: February 2024

This paper presents a novel approach based on the ant system algorithm for solving discrete optimization problems. The proposed method is based on path construction, path improvement techniques, and the footprint mechanism. Some information about the optimization problem and collective intelligence is used in order to create solutions in the path construction phase. In the path improvement phase, neighborhood operations are applied to the solution, which is the best of the population and is obtained from the path construction phase. The collective intelligence in the path construction phase is based on a footprint mechanism, and more footprints on the arc improve the selection chance of this arc. A selection probability is also balanced by using information about the problem (e.g., the distance between nodes for a traveling salesman problem). The performance of the proposed method has been investigated on 25 traveling salesman problems and compared with state-of-the-art algorithms. The experimental comparisons show that the proposed method produced comparable results for the problems dealt with in this study.
Credit and Loan Approval Classification Using a Bio-Inspired Neural Network
Authors: Mourtas Spyridon D. , Katsikis Vasilios N. , Stanimirović Predrag S. , Kazakovtsev Lev A.
Published: February 2024

Numerous people are applying for bank loans as a result of the banking industry’s expansion, but because banks only have a certain amount of assets to lend to, they can only do so to a certain number of applicants. Therefore, the banking industry is very interested in finding ways to reduce the risk factor involved in choosing the safe applicant in order to save lots of bank resources. These days, machine learning greatly reduces the amount of work needed to choose the safe applicant. Taking this into account, a novel weights and structure determination (WASD) neural network has been built to meet the aforementioned two challenges of credit approval and loan approval, as well as to handle the unique characteristics of each. Motivated by the observation that WASD neural networks outperform conventional back-propagation neural networks in terms of sluggish training speed and being stuck in local minima, we created a bio-inspired WASD algorithm for binary classification problems (BWASD) for best adapting to the credit or loan approval model by utilizing the metaheuristic beetle antennae search (BAS) algorithm to improve the learning procedure of the WASD algorithm. Theoretical and experimental study demonstrate superior performance and problem adaptability. Furthermore, we provide a complete MATLAB package to support our experiments together with full implementation and extensive installation instructions.
Vertical Mental Timeline Is Not Influenced by VisuoSpatial Processing
Authors: Beracci Alessia , Fabbri Marco
Published: February 2024

The results examining the direction (bottom-to-top vs. top-to-bottom) of the mental vertical timeline are not conclusive. The visuospatial processing of temporal stimuli along vertical space could influence this time representation. This study aimed to investigate whether and how the visuospatial processing stage modulated the vertical timeline in an online temporal categorization task. In three studies, Italian university students (N = 150) responded more quickly to words expressing the past with a down arrow key, and more quickly to words expressing the future with an up arrow key, irrespective of whether the words were located in the top, middle, or bottom space (Experiment 1), or were presented downward (from top to bottom; Experiment 2A) or upward (from bottom to top Experiment 2B). These results suggest that the representation of time was not influenced by the visuospatial processing. The daily experience with verticality (e.g., to reach the attic, the lift goes up) could explain the bottom-to-top direction of the mental timeline.
Investigating the Impact of Na2WO4 Doping in La2O3-Catalyzed OCM Reaction: A Structure–Activity Study via In Situ XRD-MS
Authors: Wang Danyu , Lang Junyu , Qiu Zhehao , Ding Ningxujin , Yang Yong
Published: February 2024

The La2O3 catalyst exhibits good performance in OCM reactions for its promising C2 selectivity and yield. Previous studies have affirmed that the formation of carbonates in La2O3 impedes the catalyst’s activity as a result of poisoning from CO2 exposure. In this study, a series of Na2WO4-impregnated La2O3 catalysts were synthesized to investigate the poisoning-resistant effect. The bulk phase and kinetics of the catalysts were analyzed in reactors employed with in situ XRD-MS and online MS, focusing on the CO2 adsorption on La2O3 and the phase transition process to La2O2CO3 in temperature zone correlated to OCM light-off. In situ XRD analysis revealed that, with Na2WO4 doped, CO2 exposure at elevated temperatures formed La2O2CO3 in tetragonal crystal phases, exhibiting distinctive differences from the hexagonal phase carbonates in undoped commercial La2O3. The ability to develop tetragonal or monoclinic La2O2CO3 was suggested as a descriptor to assess the sensitivity of La2O3 catalysts to CO2 adsorption, a tunable characteristic found in this study through varying Na2WO4 doping levels. Coupled XRD-MS analysis of CO2 adsorption uptake and phase change further confirmed a positive dependence between the resistivity of La2O3 catalyst to CO2 adsorption and its low-temperature C2 selectivity. The results extended the previous CO2 poisoning effect from multiple perspectives, offering a novel modification approach for enhancing the low-temperature performance of La2O3 catalysts in OCM.
Software Tools for 2D Cell Segmentation
Authors: Liu Ping , Li Jun , Chang Jiaxing , Hu Pinli , Sun Yue , Jiang Yanan , Zhang Fan , Shao Haojing
Published: February 2024

Cell segmentation is an important task in the field of image processing, widely used in the life sciences and medical fields. Traditional methods are mainly based on pixel intensity and spatial relationships, but have limitations. In recent years, machine learning and deep learning methods have been widely used, providing more-accurate and efficient solutions for cell segmentation. The effort to develop efficient and accurate segmentation software tools has been one of the major focal points in the field of cell segmentation for years. However, each software tool has unique characteristics and adaptations, and no universal cell-segmentation software can achieve perfect results. In this review, we used three publicly available datasets containing multiple 2D cell-imaging modalities. Common segmentation metrics were used to evaluate the performance of eight segmentation tools to compare their generality and, thus, find the best-performing tool.
The Role of Psychological Parental Control and Internalizing Problems in the Etiology of Vigorexia and Orthorexia in Adolescence
Authors: Guerra Giulia Carlotta , Paone Antonio , Lionetti Francesca , Spinelli Maria , Fasolo Mirco , D’Urso Giulio
Published: February 2024

The present study aims to explore the forms of psychological parental control that are interconnected with dysfunctional emotional states (i.e., anxiety and depression), and how these internalizing problems may manifest as distorted behaviors (i.e., vigorexic and orthorexic behaviors) during adolescence. Participants included 403 Italian adolescent athletes (231 boys and 172 girls) aged 14 to 18 years. The participants completed self-report questionnaires designed to assess psychological parental control oriented towards dependence and achievement, anxiety and depression, and vigorexia and orthorexia. The results highlight how both forms of psychological parental control predict anxiety and depression. Furthermore, anxiety was found to be linked to both vigorexic and orthorexic behaviors, while depression is connected only to vigorexia. This study delves into the intricacies of parental influence on adolescents, revealing that both dependency-oriented and success-oriented psychological parental control have notable implications for the mental well-being of adolescents. The findings underscore the interconnectedness of these factors, demonstrating that anxiety can set off a chain reaction, leading to engagement in vigorexic and orthorexic behaviors. On the other hand, depression appears to be uniquely associated with vigorexia. These insights contribute to our understanding of the complex dynamics between parental control and adolescent mental health. The implications of this research extend to both theoretical frameworks and practical interventions, emphasizing the need for a nuanced approach to supporting adolescents in navigating these challenges.
Enterocins Produced by Enterococci Isolated from Breast-Fed Infants: Antilisterial Potential
Authors: Landete José María , Montiel Raquel , Rodríguez-Mínguez Eva , Arqués Juan L.
Published: February 2024

Enterocins are bacteriocins synthesized by Enterococcus strains that show an interesting antimicrobial effectiveness against foodborne pathogens such as Listeria monocytogenes. The objectives of this study were to identify and analyze the expression of enterocin genes of Enterococcus isolated from breast-fed infants and evaluate their ability to inhibit three human isolates of virulent L. monocytogenes, as well as some probiotic bacteria. The susceptibility of the strains of L. monocytogenes to fifteen antibiotics was tested, detecting their resistance to cefoxitin (constitutively resistant), oxacillin, and clindamycin. The production of enterocins A, B, and P was observed in Enterococcus faecium isolates, while enterocin AS-48 was detected in an Enterococcus faecalis isolate. AS-48 showed antilisterial activity by itself, while the joint action of enterocins A and B or B and P was necessary for inhibiting L. monocytogenes, demonstrating the synergistic effect of those combinations. The presence of multiple enterocin genes does not assure the inhibition of L. monocytogenes strains. However, the expression of multiple enterocin genes showed a good correlation with the inhibition capacity of these strains. Furthermore, the potential beneficial strains of lactobacilli and bifidobacteria examined were not inhibited by any of the enterocins produced individually or in combination, with the exception of Bifidobacterium longum BB536, which was inhibited by enterocin AS-48 and the joint production of enterocins A and B or B and P. The enterocins studied here could be candidates for developing alternative treatments against antibiotic-resistant bacterial infections. Moreover, these selected enterocin-producing E. faecium strains isolated from breast-fed infants could be used as probiotic strains due to their antilisterial effect, as well as the absence of virulence factors.