bluuebunny/crossref_metadata_2025 huggingface dataset:
Hematopoietic Npc1 mutation shifts gut microbiota composition in Ldlr−/− mice on a high-fat, high-cholesterol diet
Authors: Houben Tom , Penders John , Oligschlaeger Yvonne , dos Reis Inês A. Magro , Bonder Marc-Jan , Koonen Debby P. , Fu Jingyuan , Hofker Marten H. , Shiri-Sverdlov Ronit
Published: October 2019

While the link between diet-induced changes in gut microbiota and lipid metabolism in metabolic syndrome (MetS) has been established, the contribution of host genetics is rather unexplored. As several findings suggested a role for the lysosomal lipid transporter Niemann-Pick type C1 (NPC1) in macrophages during MetS, we here explored whether a hematopoietic Npc1 mutation, induced via bone marrow transplantation, influences gut microbiota composition in low-density lipoprotein receptor knockout (Ldlr−/−) mice fed a high-fat, high-cholesterol (HFC) diet for 12 weeks. Ldlr−/− mice fed a HFC diet mimic a human plasma lipoprotein profile and show features of MetS, providing a model to explore the role of host genetics on gut microbiota under MetS conditions. Fecal samples were used to profile the microbial composition by 16 s ribosomal RNA gene sequencing. The hematopoietic Npc1 mutation shifted the gut microbiota composition and increased microbial richness and diversity. Variations in plasma lipid levels correlated with microbial diversity and richness as well as with several bacterial genera. This study suggests that host genetic influences on lipid metabolism affect the gut microbiome under MetS conditions. Future research investigating the role of host genetics on gut microbiota might therefore lead to identification of diagnostic and therapeutic targets for MetS.
Evaluation of Small Molecule Drug Uptake in Patient-Derived Prostate Cancer Explants by Mass Spectrometry
Authors: Mutuku Shadrack M. , Trim Paul J. , Prabhala Bala K. , Irani Swati , Bremert Kayla L. , Logan Jessica M. , Brooks Douglas A. , Stahl Jürgen , Centenera Margaret M. , Snel Marten F. , Butler Lisa M.
Published: October 2019

Patient-derived explant (PDE) culture of solid tumors is increasingly being applied to preclinical evaluation of novel therapeutics and for biomarker discovery. In this technique, treatments are added to culture medium and penetrate the tissue via a gelatin sponge scaffold. However, the penetration profile and final concentrations of small molecule drugs achieved have not been determined to date. Here, we determined the extent of absorption of the clinical androgen receptor antagonist, enzalutamide, into prostate PDEs, using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and matrix-assisted laser/desorption ionisation (MALDI) mass spectrometry imaging (MSI). In a cohort of 11 PDE tissues from eight individual patients, LC-MS/MS quantification of PDE homogenates confirmed enzalutamide (10 µM) uptake by all PDEs, which reached maximal average tissue concentration of 0.24–0.50 ng/µg protein after 48 h culture. Time dependent uptake of enzalutamide (50 µM) in PDEs was visualized using MALDI MSI over 24–48 h, with complete penetration throughout tissues evident by 6 h of culture. Drug signal intensity was not homogeneous throughout the tissues but had areas of markedly high signal that corresponded to drug target (androgen receptor)-rich epithelial regions of tissue. In conclusion, application of MS-based drug quantification and visualization in PDEs, and potentially other 3-dimensional model systems, can provide a more robust basis for experimental study design and interpretation of pharmacodynamic data.
Causes of large projected increases in hurricane precipitation rates with global warming
Authors: Liu Maofeng , Vecchi Gabriel A. , Smith James A. , Knutson Thomas R.
Published: October 2019

Recent climate modeling studies point to an increase in tropical cyclone rainfall rates in response to climate warming. These studies indicate that the percentage increase in tropical cyclone rainfall rates often outpaces the increase in saturation specific humidity expected from the Clausius-Clapeyron relation (~7% °C−1). We explore the change in tropical cyclone rainfall rates over all oceans under global warming using a high-resolution climate model with the ability to simulate the entire intensity spectrum of tropical cyclones. Consistent with previous results, we find a robust increase of tropical cyclone rainfall rates. The percentage increase for inner-core tropical cyclone rainfall rates in our model is markedly larger than the Clausius-Clapeyron rate. However, when the impact of storm intensity is excluded, the rainfall rate increase shows a much better match with the Clausius-Clapeyron rate, suggesting that the “super Clausius-Clapeyron” scaling of rainfall rates with temperature increase is due to the warming-induced increase of tropical cyclone intensity. The increase of tropical cyclone intensity and environmental water vapor, in combination, explain the tropical cyclone rainfall rate increase under global warming.
The repurposing of type I-E CRISPR-Cascade for gene activation in plants
Authors: Young Joshua K. , Gasior Stephen L. , Jones Spencer , Wang Lijuan , Navarro Pedro , Vickroy Becca , Barrangou Rodolphe
Published: October 2019

CRISPR-Cas systems are robust and facile tools for manipulating the genome, epigenome and transcriptome of eukaryotic organisms. Most groups use class 2 effectors, such as Cas9 and Cas12a, however, other CRISPR-Cas systems may provide unique opportunities for genome engineering. Indeed, the multi-subunit composition of class 1 systems offers to expand the number of domains and functionalities that may be recruited to a genomic target. Here we report DNA targeting in Zea mays using a class 1 type I-E CRISPR-Cas system from S. thermophilus. First, we engineer its Cascade complex to modulate gene expression by tethering a plant transcriptional activation domain to 3 different subunits. Next, using an immunofluorescent assay, we confirm Cascade cellular complex formation and observe enhanced gene activation when multiple subunits tagged with the transcriptional activator are combined. Finally, we examine Cascade mediated gene activation at chromosomal DNA targets by reprogramming Zea mays cells to change color.
Wavelength-decoupled geometric metasurfaces by arbitrary dispersion control
Authors: Yoon Gwanho , Kim Jeonghyun , Mun Jungho , Lee Dasol , Nam Ki Tae , Rho Junsuk
Published: October 2019

Conventional multicolor metaholograms suffer from the fundamental limitations of low resolution and irreducible noise because the unit structure functionality is still confined to a single wavelength. Here, we propose wavelength-decoupled metasurfaces that enables to control chromatic phase responses independently in a full range from 0 to 2π for each wavelength. The propagation phase associated with the geometric phase of rectangular dielectric nanostructures plays a critical role to embed a dual phase response into a single nanostructure. A multicolor metahologram is also demonstrated to verify the feasibility of our method that breaks through the fundamental constraints of conventional multicolor metaholograms. Our approach can be extended to achieve complete control of chromatic phase responses in the visible for general dual-wavelength diffractive optical elements.
Organic Hierarchical Thermoelectric Materials
Authors: Zhang Zimeng , Liu Yuchen , Wang Shiren
Published: October 2019

Organic hybrids are promising thermoelectric materials to convert thermal energy into electricity. In this chapter, we demonstrate a series of thermoelectric materials with novel hierarchical nanostructures consisting of zero-dimensional fullerene and two-dimensional organic nanosheets (graphene)/inorganic nanosheets (titanium disulfide). By carefully tuning the hierarchical structure, the engineered hybrids exhibit encouraging thermoelectric performance.
Conducting Polymer-based Organic–Inorganic Thermoelectric Nanocomposites
Authors: Yao Q. , Shi W. , Qu S. Y. , Chen L. D.
Published: October 2019

Conducting polymers, such as polyaniline (PANI), poly (3,4-ethylenedioxythiophene) (PEDOT) and poly (3-hexythiophene) (P3HT), have attracted wide attention as organic TE materials. However, poor electrical transport properties of polymers, including the low electrical conductivity (σ) and low Seebeck coefficient (S), greatly prevent conducting polymers from serving as high-performance TE materials. In this context, the preparation of organic/inorganic composites or hybrids has been successfully applied to optimize the thermoelectric properties of polymers, wherein conventional inorganic components, including carbon nanotubes (CNTs), graphenes (GPs), metals, and metallic compounds etc., are employed. The adjustment of doping level, ordering arrangement of polymer molecular chains, organic/inorganic interfacial effect control, regulating charge transfer by the junctions and forming nano-intercalated superlattice structure have been identified as potential strategies to enhance TE properties. At present, the reported maximum ZT value of conducting polymer/inorganic nanocomposites has reached 0.58, which can be comparable with that of inorganic thermoelectric materials. In this chapter, recent progress in the preparation, modification, and performance optimization of conducting polymers and their nanocomposites are highlighted.
A BODIPY-carbazole hybrid as a fluorescent probe: the design, synthesis, and discrimination of surfactants and the determination of the CMC values
Authors: Niu Xiao-xiao , Xu Qin-chao , Li An-zhen , Li Yang-jie , Zhang Xiao-tai , Zhang Yuan , Xing Guo-wen
Published: October 2019

A novel fluorescent probe (BDP-Zn2+) was developed to efficiently discriminate four kinds of surfactants and determine the CMC values.
Cucurbit[8]uril-mediated pseudo[2,3]rotaxanes
Authors: Wu Guanglu , Szabó István , Rosta Edina , Scherman Oren A.
Published: October 2019

Cucurbit[8]uril-mediated pseudo[2,3]rotaxanes constrain chromophores into dimeric stacks with effective electron-delocalisation along the long-molecular axis.
Intermetallic compounds with high hydrogen evolution reaction performance: a case study of a MCo2 (M = Ti, Zr, Hf and Sc) series
Authors: Zhang Peng , Xue Huai-Guo , Suen Nian-Tzu
Published: October 2019

Noble metals (e.g., Ru, Ir and Pt) or their derivatives exhibit very appealing activity toward the hydrogen evolution reaction (HER), but their high price and low reserves impede their wide use.
Halogen bonding in 5-iodo-1-arylpyrazoles investigated in the solid state and predicted by solution13C-NMR spectroscopy
Authors: Popa Marcel Mirel , Man Isabela Costinela , Draghici Constantin , Shova Sergiu , Caira Mino R. , Dumitrascu Florea , Dumitrescu Denisa
Published: October 2019

Halogen bonding as important directional forces in the supramolecular structure of iodinated 1-arylpyrazoles.
A global CHIPR potential energy surface for ground-state C3H and exploratory dynamics studies of reaction C2+ CH → C3+ H
Authors: Rocha C. M. R. , Varandas A. J. C.
Published: October 2019

Schematic representation of C3H potential energy surface highlighting stationary points and interconversion pathways.
Independent tunable multi-band absorbers based on molybdenum disulfide metasurfaces
Authors: Wang Jicheng , Wang Xiaoyu , Hu Zheng-Da , Tang Yang , Balmakou Aliaksei , Khakhomov Sergei , Liu Dongdong
Published: October 2019

Dual-band independent absorbers with an array of stacked MoS2 nanodisks are achieved. The structure can be useful for the design of chemical sensors and detectors.
Degradation of iridium oxides via oxygen evolution from the lattice: correlating atomic scale structure with reaction mechanisms
Authors: Kasian Olga , Geiger Simon , Li Tong , Grote Jan-Philipp , Schweinar Kevin , Zhang Siyuan , Scheu Christina , Raabe Dierk , Cherevko Serhiy , Gault Baptiste , Mayrhofer Karl J. J.
Published: October 2019

Combination of atom probe tomography, isotope-labelling and online electrochemical mass spectrometry provides direct correlation of atomic scale structure of Ir oxide catalysts with the mechanism of oxygen formation from the lattice atoms.
Evaluation of reverse osmosis drinking water treatment of riverbank filtrate using bioanalytical tools and non-target screening
Authors: Albergamo Vittorio , Escher Beate I. , Schymanski Emma L. , Helmus Rick , Dingemans Milou M. L. , Cornelissen Emile R. , Kraak Michiel H. S. , Hollender Juliane , de Voogt Pim
Published: October 2019

Organic micropollutants that occurred in a natural drinking water source induced effects that were not detectable after reverse osmosis. Bioactive compounds were characterised by non-target screening of LC-HRMS data using open cheminformatics approaches.
Optimising the supercritical angle fluorescence structures in polymer microfluidic biochips for highly sensitive pathogen detection: a case study on Escherichia coli
Authors: Nguyen Trieu , Anh Ngo Tien , Duong Bang Dang , Wolff Anders
Published: October 2019

This paper provides an in-depth theoretical analysis and experimental results for optimisation of supercritical angle fluorescence (SAF) structures in polymer microfluidic chips for their application in the highly-sensitive detection of pathogens.
Cu(ii) phenanthroline–phenazine complexes dysregulate mitochondrial function and stimulate apoptosis
Authors: Rochford Garret , Molphy Zara , Kavanagh Kevin , McCann Malachy , Devereux Michael , Kellett Andrew , Howe Orla
Published: October 2019

Herein we report an in-depth study on the cytotoxic mechanism of action of four developmental cytotoxic copper(ii) complexes: [Cu(phen)2]2+ (Cu-Phen); [Cu(DPQ)(Phen)]2+ (Cu-DPQ-Phen); [Cu(DPPZ)(Phen)]2+; and [Cu(DPPN)(Phen)]2+ (where Phen = 1,10-phenanthroline, DPQ = dipyrido[3,2-f:2′,3′-h]quinoxaline, DPPZ = dipyrido[3,2-a:2′,3′-c]phenazine, and DPPN = benzo[i]dipyrido[3,2-a:2′,3′-c]phenazine). This complex class is known for its DNA intercalative properties and recent evidence—derived from an in vivo proteomic study—supports the potential targeting of mitochondrial function. Therefore, we focused on mitochondrial-mediated apoptosis related to cytotoxic activity and the potential impact these agents have on mitochondrial function. The Cu(ii) complexes demonstrated superior activity regardless of aromatic extension within the phenazine ligand to the previously demonstrated activity of cisplatin. Unique toxicity mechanisms were also identified in prior demonstrated cisplatin sensitive and resistant cell lines. Double strand breaks in genomic DNA, quantified by γH2AX foci formation, were then coupled with apoptotic gene expression to elucidate the mechanisms of cell death. These results indicate that while DNA damage-induced apoptosis by BAX, XIAP and caspase-9 and -3 expression is moderate for the Cu(ii) complexes when compared to cisplatin, protein targets independent of DNA exert a multimodal mechanistic effect. Significantly, mitochondrial gene expression of oxidative stress, protease expression, and fission/fusion processes—upregulated HMOX, DRP1 and LON, respectively—indicated an increased oxidative damage associated with compromised mitochondrial health upon exposure to these agents. These data support a unique mode of action by these complexes and provide valuable evidence of the developmental potential of these therapeutic inorganic complexes.
Highly efficient COx-free hydrogen evolution activity on rod Fe2N catalysts for ammonia decomposition
Authors: Lei Bowen , Wen Jie , Ren Shan , Zhang Lianhong , Zhang Hui
Published: October 2019

The morphology of Fe2O3 precursors had a significant effect on the Fe2N catalyst crystallite size, components and activity.
The molecular mechanism of robust macrophage immune responses induced by PEGylated molybdenum disulfide
Authors: Gu Zonglin , Chen Serena H. , Ding Zhaowen , Song Wei , Wei Wei , Liu Shengtang , Ma Guanghui , Zhou Ruhong
Published: October 2019

Molecular dynamics simulation and experiments reveal that PEGylated MoS2 triggers more sustained stimulation to macrophage than pristine MoS2via slower/prolonged membrane penetration and stronger membrane adsorption.
Photocatalytic activity of exfoliated graphite–TiO2nanoparticle composites
Authors: Guidetti Gloria , Pogna Eva A. A. , Lombardi Lucia , Tomarchio Flavia , Polishchuk Iryna , Joosten Rick R. M. , Ianiro Alessandro , Soavi Giancarlo , Sommerdijk Nico A. J. M. , Friedrich Heiner , Pokroy Boaz , Ott Anna K. , Goisis Marco , Zerbetto Francesco , Falini Giuseppe , Calvaresi Matteo , Ferrari Andrea C. , Cerullo Giulio , Montalti Marco
Published: October 2019

We report the photocatalytic performance of composites prepared in a one-step process by liquid phase exfoliation of graphite and TiO2at atmospheric pressure and in water, without heat or surfactants, starting from low-cost commercial reagents.
Light activated synthesis of the atomically precise fluorescent silver cluster Ag18(Capt)14
Authors: Ramsay Hannah S. , Silverman Max M. , Simon David , Oleschuk Richard D. , Stamplecoskie Kevin G.
Published: October 2019

A photochemical synthetic route has been tuned to direct the growth of the atomically precise fluorescent silver cluster, Ag18(Capt)14.
Polysaccharide-containing block copolymers: synthesis and applications
Authors: Volokhova Anastasia S. , Edgar Kevin J. , Matson John B.
Published: October 2019

Chemical methods to generate polysaccharide-containing block copolymers are enabling these polymers to achieve their potential as sustainable materials in a variety of applications.
Push–pull type quinoidal perylene showing solvent polarity dependent diradical character and negative solvatochromism
Authors: Zeng Wangdong , Wu Jishan
Published: October 2019

A push–pull perylene dye shows solvent dependent diradical character and negative solvatochromism.
Effect of boundary chain folding on thermal conductivity of lamellar amorphous polyethylene
Authors: Ouyang Yulou , Zhang Zhongwei , Xi Qing , Jiang Pengfei , Ren Weijun , Li Nianbei , Zhou Jun , Chen Jie
Published: October 2019

Boundary chain folding leads to inhomogeneous thermal transport in lamellar amorphous polyethylene with uniform mass density.
Mechanochemistry-assisted hydrolysis of softwood over stable sulfonated carbon catalysts in a semi-batch process
Authors: Scholz David , Xie Jingwei , Kröcher Oliver , Vogel Frédéric
Published: October 2019

A two-step process employing stable sulfonated carbons, overcomes the challenging recyclability of mineral acids used in conventional hydrolysis processes.
Calcination kinetics of cement raw meals under various CO2 concentrations
Authors: Fernandez Jose Ramon , Turrado Sandra , Abanades Juan Carlos
Published: October 2019

The calcium looping CO2 capture process, CaL, represents a promising option for the decarbonisation of cement plants, due to the intrinsic benefit of using the spent CO2 sorbent as a feedstock for the plant.
Facile room-temperature growth of nanostructured CuBi2O4 for selective electrochemical reforming and photoelectrochemical hydrogen evolution reactions
Authors: Lin Chia-Yu , Lin Shao-Yu , Tsai Ming-Chun , Wu Cheng-Hsien
Published: October 2019

Facile, room-temperature, and surfactant-free seed-mediated chemical bath deposition was developed to directly grow nanostructured CuBi2O4 with promising properties towards electro-reforming of glucose and PEC hydrogen generation.
Sandwich structured WO3 nanoplatelets for highly efficient photoelectrochemical water splitting
Authors: Zheng Guangwei , Wang Jinshu , Zu Guannan , Che Haibing , Lai Chen , Li Hongyi , Murugadoss Vignesh , Yan Chao , Fan Jincheng , Guo Zhanhu
Published: October 2019

Promising PEC water splitting activity with a photocurrent density of 3.16 mA cm−2 at 1.23 V vs. RHE was demonstrated in sandwich structured WO3 with exposed highly reactive (002) facet and superior crystallinity of 2-D nanoplatelets.
How artificial intelligence is driving innovation in the pharmaceutical industry
Authors: Hunter Jackie
Published: October 2019

Although disease affects everyone, and trillions of pounds have been spent on research and development, there are still thousands of diseases without any treatment. There are over 300 million people suffering from rare diseases for which no medicine will be developed anytime soon, unless we dramatically disrupt the existing economic and development models.
Artificial intelligence decision-making in mobile health
Authors: Menictas Marianne , Rabbi Mashfiqui , Klasnja Predrag , Murphy Susan
Published: October 2019

It is likely that you or someone you know is affected by a chronic health condition. For example, a staggering six in 10 adults in the USA are currently suffering from a chronic disease (National Center for Chronic Disease Prevention and Health Promotion, 2019). Unfortunately, chronic conditions are not treatable overnight, but they can often be improved by regular incorporation of preventative behaviours (e.g., taking medication, healthy sleeping habits, being physically active, healthy eating, etc.). However, due to the many contingencies that arise in our lives, regular incorporation of healthy behaviours is difficult, and often when we need help in enacting these behaviours, support from clinical professionals is not available.
Silencing of lncRNA EZR-AS1 inhibits proliferation, invasion, and migration of colorectal cancer cells through blocking transforming growth factor β signaling
Authors: Liu Zhenhua , Wang Ning , Wang Feiqing , Zhang Shuaimin , Ding Jie
Published: October 2019

Long non-coding RNA (lncRNA) plays a key regulatory role in the pathogenesis of colorectal cancer (CRC). In the present study, the specific regulatory role of lncRNA ezrin antisense RNA 1 (EZR-AS1) on CRC was investigated. The expression of lncRNA EZR-AS1 was significantly up-regulated in CRC cell lines (HCT8, HCT116, HT29, and SW620 cells), which was significantly different from that of normal human fetal colonic mucosa cells (FHC cells) (P<0.01). HCT116 and HT29 cells were then transfected with EZR-AS1 shRNA (sh-EZR-AS1) to silence lncRNA EZR-AS1 (P<0.01). When compared with the Control, after transfection of SH-EZR-AS1, E-cadherin was up-regulated, Vimentin was down-regulated, the apoptosis rate was increased, the cell viability, wound healing rate, and the number of invasive cells were decreased in HCT116 and HT29 cells (P<0.05). Silencing of lncRNA EZR-AS also significantly reduced the tumor volume and weight in mice injected with sh-EZR-AS1-transfected HCT116 and HT29 cells (P<0.05). The regulatory relationship between lncRNA EZR-AS1 and transforming growth factor β (TGF-β) signaling was further identified in CRC cells. Silencing of lncRNA EZR-AS1 significantly down-regulated TGF-β, Smad2, and α-SMA expression in HCT116 and HT29 cells at the protein level (P<0.05). The intervention of SB431542 (a TGF-β receptor blocker) and silencing of Smad2 both significantly down-regulated lncRNA EZR-AS1 expression in HCT116 and HT29 cells (P<0.01). In conclusion, silencing of lncRNA EZR-AS1 inhibited the proliferation, invasion, migration, and epithelial–mesenchymal transition, and promoted the apoptosis of CRC cells through blocking TGF-β signaling.
Weighted gene co-expression network analysis reveals specific modules and hub genes related to neuropathic pain in dorsal root ganglions
Authors: Cheng Nan , Zhang Zheng , Guo Yue , Qiu Zhuo-Lin , Du Jing-Yi , Hei Zi-Qing , Li Xiang
Published: October 2019

Neuropathic pain is a common, debilitating clinical issue. Here, the weighted gene co-expression network analysis (WGCNA) was used to identify the specific modules and hub genes that are related to neuropathic pain. The microarray dataset of a neuropathic rat model induced by tibial nerve transection (TNT), including dorsal root ganglion (DRG) tissues from TNT model (n=7) and sham (n=8) rats, was downloaded from the ArrayExpress database (E-MTAB-2260). The co-expression network modules were identified by the WGCNA package. The protein–protein interaction (PPI) network was constructed, and the node with highest level of connectivity in the network were identified as the hub gene. A total of 1739 genes and seven modules were identified. The most significant module was the brown module, which contained 215 genes that were primarily associated with the biological process (BP) of the defense response and molecular function of calcium ion binding. Furthermore, C–C motif chemokine ligand 2 (Ccl2), Fos and tissue inhibitor of metalloproteinase 1 (Timp1) which were identified as the hub genes in the PPI network and two subnetworks separately. The in vivo studies validated that mRNA and protein levels of Ccl2, Fos and Timp1 were up-regulated in DRG and spinal cord tissues after TNT. The present study offers novel insights into the molecular mechanisms of neuropathic pain in the context of peripheral nerve injury.
Association between dectin-1 gene single nucleotide polymorphisms and fungal infection: a systemic review and meta-analysis
Authors: Zhou Peiru , Xie Yufei , Yan Zhimin , Liu Xiaosong , Hua Hong
Published: October 2019

Objectives: To investigate the association between dectin-1 gene single nucleotide polymorphisms (SNPs) and susceptibility to fungal infection (FI). Methods: Databases were searched electronically and manually to identify case–control studies concerning dectin-1 SNPs and FI, which were published up to 12 November 2018. The Newcastle–Ottawa Quality Assessment Scale was used to determine the study quality and bias. The SNP frequencies of the B (the variant or minor allele) and A (the wild or major allele) alleles of the dectin-1 gene in both cases and controls were analyzed with regard to FI susceptibility. Results: Eight high-quality studies were included in the review. Systemic review of the included studies demonstrated that dectin-1 SNPs rs3901533 and rs7309123 might be associated with susceptibility to invasive pulmonary aspergillosis infection; moreover, rs16910527 SNP can possibly increase the susceptibility to oropharyngeal candidiasis in HIV-positive patients. The meta-analysis identified significant associations between dectin-1 SNPs and overall FI risk in the homozygote model (pooled odds ratio (OR) 1.77, P=0.04). When classified by subtypes, significant associations were also found for deep FI in the homozygote model (pooled OR 2.46, P=0.01) and the recessive model (pooled OR 2.85, P=0.002). There appeared to be no significant association between dectin-1 SNPs and superficial FI. Conclusion: Systemic review of the included studies suggested that dectin-1 SNPs rs3901533, rs7309123, and rs16910527 might play a role in FI susceptibility. The meta-analysis provided convincing evidence that dectin-1 SNPs might have an important role in FI susceptibility, especially for deep FI.
Synthetic tissues
Authors: Bayley Hagan , Cazimoglu Idil , Hoskin Charlotte E.G.
Published: October 2019

While significant advances have been achieved with non-living synthetic cells built from the bottom-up, less progress has been made with the fabrication of synthetic tissues built from such cells. Synthetic tissues comprise patterned three-dimensional (3D) collections of communicating compartments. They can include both biological and synthetic parts and may incorporate features that do more than merely mimic nature. 3D-printed materials based on droplet-interface bilayers are the basis of the most advanced synthetic tissues and are being developed for several applications, including the controlled release of therapeutic agents and the repair of damaged organs. Current goals include the ability to manipulate synthetic tissues by remote signaling and the formation of hybrid structures with fabricated or natural living tissues.
Hadronic light-by-light scattering in the muon g − 2
Authors: Nyffeler Andreas
Published: October 2019

We briefly review the current status of the hadronic light-by-light scattering contribution to the anomalous magnetic moment of the muon. Based on various model calculations in the literature, we obtain the estimate $ \mathop a\nolimits_\mu ^{HLbL} = (102 \pm 39) \times \mathop {10}\nolimits^{ - 11} $. Recent developments including more model-independent approaches using dispersion relations and lattice QCD, that could lead to a more reliable estimate, are also discussed.
Variations on Photon Vacuum Polarization
Authors: Jegerlehner Fred
Published: October 2019

I provide updates for the theoretical predictions of the muon and electron anomalous magnetic moments, for the shift in the fine structure constant α(MZ )and for the weak mixing parameter $ \mathop {\sin }\nolimits^2 \mathop \Theta \nolimits_w (\mathop M\nolimits_Z ) $. Phenomenological results for Euclidean time correlators, the key objects in the lattice QCD approach to hadronic vacuum polarization, are briefly considered. Furthermore,I present a list of isospin breaking and electromagnetic corrections for the lepton moments, which may be used to supplement lattice QCD results obtained in the isospin limit and without the e.m. corrections.
Recent Results on Meson Decays from A2
Authors: Adlarson Patrik
Published: October 2019

Light meson decays are used to investigate topics related to fundamental aspects of particle physics. Precision measurements of meson Dalitz decays give input to theoretical evaluations of the Hadronic Light-by-Light contribution (HLbL) to the anomalous magnetic moment of the muon. The A2 collaboration, using the Crystal Ball/TAPS setup at MAMI, has recently published several high precision results on transition form factors which are related to HLbL. Pseudoscalar η’ decays allow for studies of topics like ππ scattering lengths, eﬀective field theories and fundamental symmetries. In 2014 the collaboration had a dedicated experimental campaign with one of its main goals to measure the dynamics of η’→ π0π0η with high precision. A brief overview of the experimental setup, physics motivations, analyses and results are given.
Overview of the BINP accelerator complex
Authors: Shwartz Dmitry , Emanov Fedor , Piminov Pavel
Published: October 2019

The overview of two running BINP electron-positron colliders VEPP-4M and VEPP-2000 is presented. Since 2016 both colliders are joint to the single accelerator complex via common injector that supplies more intensive beams. In 2017 VEPP-2000 started data taking after 3 years of upgrade. The project of Super-Charm-Tau factory waits for the final government’s approval being considered as one of 6 mega-science project in Russia.
Recent results on hadronic spectroscopy at LHCb
Authors: Needham Matthew
Published: October 2019

The LHCb experiment is optimized to make precision measurements in the flavour sector. The large datasets collected between 2010 and 2016 allow to study the properties of heavy hadrons with unprecedented precision. In these proceedings recent results related to three topics are discussed: studies of charmonium production and properties using inclusive b → φφX decays, the observation of charmed pentaquarks and exotic mesons, and the observation of five new excited Ωc baryons.
Theory of hadronic molecules applied to the XYZ states
Authors: Hanhart Christoph
Published: October 2019

In recent years data have been accumulated at various experiments about states in the heavy quarkonium mass range that seem to be inconsistent with the most simple variants of the quark model. In this contribution it is demonstrated that most of those data are consistent with a dominant molecular nature of those states. It is also discussed which kind of observables are sensitive to the molecular component and which are not.
Eta and eta’ physics in KLOE
Authors: Berlowski Marcin
Published: October 2019

We present results obtained by the KLOE Collaboration at the DAфNE e+e− collider located in Frascati Laboratories, Italy. The results concern precise measurements of several η meson decays such as Dalitz slope parameters and charge asymmetries for $ \eta \to \mathop \pi \nolimits^ + \mathop \pi \nolimits^ - \mathop \pi \nolimits^0 $, branching ratio and plane asymmetry for $ \eta \to \mathop \pi \nolimits^ + \mathop \pi \nolimits^ - \mathop {\rm{e}}\nolimits^ + \mathop {\rm{e}}\nolimits^ - $, and first observation of $ \eta \to \mathop {\rm{e}}\nolimits^ + \mathop {\rm{e}}\nolimits^ - \mathop {\rm{e}}\nolimits^ + \mathop {\rm{e}}\nolimits^ - $ along with its branching ratio determination. Also preliminary studies of $ \eta \to \mathop \pi \nolimits^0 \gamma \gamma $ decay channel are presented as well as physics perspectives for many different processes for the ongoing KLOE−2 data taking.
Visite virtuelle des salles blanches ESIEE
Authors: Grandpierre T.
Published: October 2019

Nous présentons un système de réalité virtuelle qui a été mis en place afin de permettre à tous de visiter virtuellement les nouvelles salles blanches de l’ESIEE. C’est une visite immersive qui peut s’effectuer à l’aide d’un casque de réalité virtuelle ou bien dans une salle spécifique de projection que nous décrivons. Ce parcours virtuel permet de se déplacer dans toutes les pièces du bâtiment ainsi que de visiter les locaux techniques. Il offre le choix d’afficher des images de synthèse ou bien des photos panoramiques. Nous décrivons ici les outils utilisés ainsi que toutes les étapes qui ont mené à la réalisation de cette application.
Croissance et caractérisation de graphène au Pôle CNFM de Lille
Authors: Ben Salk S. , Pallecchi E. , Hoel V. , Happy H.
Published: October 2019

Le graphène en particulier, et les matériaux 2D en général, sont une nouvelle filière de matériaux aux propriétés physiques très intéressantes. Leurs propriétés électroniques, thermiques et mécaniques en font des matériaux de choix pour de nombreuses applications, dans les domaines aussi que les technologies de l’information et de la communication, la santé, l’énergie, le transport. Compte tenu des potentialités de ces matériaux, de nombreux grands programmes de recherche se sont développés au niveau international, pour étudier ces matériaux, et bénéficier des innovations qui en découleraient pour le développement de nouveaux emplois et de nouvelles richesses. Sur le plan de la formation, avec le soutien du GIP CNFM et de l’IDEFI FINMINA obtenu par le réseau du CNFM, le pôle CNFM de Lille s’est doté de nouveaux équipements qui permettent d’explorer, d’analyser, et de fabriquer des composants et systèmes avec ces matériaux 2D. Il s’agit notamment d’un four de croissance de graphène, d’un spectromètre Raman permettant de caractériser les matériaux 2D, du développement d’un système de transfert du graphène sur un matériau hôte. Cette communication va présenter la méthodologies mise en place, pour sensibiliser les étudiants du master 2 sur la manipulation de ces nouveaux matériaux.
Modélisation SystemC-TLM de systèmes à base de processeur
Authors: Jovanovic S. , Weber S.
Published: October 2019

Nous présentons un ensemble de travaux pratiques qui seront dispensés au sein du Master EEA - Électronique Embarquée à l'université de Lorraine dans le cadre du module « Modélisation SystemC ». Ces TP sont destinés à initier les étudiants à la modélisation de systèmes et circuits numériques en SystemC-TLM et sont organisés autour de la suite logicielle open source Eclipse et de la chaine de compilation gcc pour la simulation, test et vérification.
L’apprentissage par projet en électronique numérique
Authors: Uhring Wilfried , Frick Vincent
Published: October 2019

Ce papier relate une expérience d’apprentissage par projet dans le cadre du module d’électronique numérique de première année à l’IUT d’Haguenau. L’apprentissage par projet met l’apprenant au coeur de son processus de formation par le biais d’une mission à accomplir. Il identifie lui-même ce qu’il doit apprendre pour pouvoir mener à bien cette mission en jouant le rôle d’animateur, de scribe, de secrétaire ou bien d’intendant au sein d’un groupe de 4 étudiants. L’apprentissage passe donc essentiellement par un travail personnel. Un exemple de déroulement pratique ainsi qu’une mission type sont décrits dans l’article. Le retour d’expérience indique que l’approche est globalement bien perçue par les apprenants, mais elle montre des limites liées à la motivation et la maturité du public visé.
Plastronique 3D et 3D-MID, programme innovant d'enseignement supérieur et de formation à l'Université de Lyon
Authors: Lombard Ph. , Gerges T. , Allard B. , Lambert S. A. , Cabrera M.
Published: October 2019

En 2015, une enquête menée par la Fondation pour l'Université de Lyon (1), auprès d’une centaine d’entreprises françaises, a montré que l'un des freins majeurs au développement de l’électronique sur substrat polymère, plus communément appelé plastronique, était le manque d'ingénieurs qualifiés ayant des compétences transdisciplinaires. Cela a été attribué à la nature intrinsèquement multi-physiques du sujet, impliquant de nombreux aspects qu’un ingénieur, non formé, peut difficilement gérer. En effet, la plastronique allie des compétences aussi bien en électronique, en plasturgie, en mécatronique, en sciences des matériaux, en chimie, etc. Une autre conclusion de cette enquête est que les entreprises ont besoin d’ingénieurs spécialisés dans tous ces domaines, mais également de responsables techniques capables de mener un projet en coopération avec les spécialistes concernés. Le défi consiste alors à proposer, en lien étroit avec les entreprises, des profils de collaborateurs appropriés capables de transcender le potentiel d'innovation de ces nouvelles technologies. Dans cet article, nous illustrerons un exemple de mini-projet réalisé sur la plateforme d’enseignement et de recherche dédiée à la plastronique sur Lyon-Saint-Etienne.
Prototypage Matériel-Logiciel de Systèmes Intégrés avec l'architecture RISC-V
Authors: Ait Said N. , Benabdenbi M. , Villanova Magalhães G.
Published: October 2019

Cet article présente un nouvel enseignement en cours de mise en place à Grenoble INP dont l'objectif est de former les étudiants à la conception conjointe matérielle-logicielle de systèmes intégrés. L'objectif principal de ce nouvel enseignement est de donner à l'étudiant une vision plus claire de l'interaction entre le matériel et le logiciel et de l'impact d'un changement de l'un sur l'autre. La plateforme utilisée est libre de droit (Rocket Chip développée à Berkeley), elle est basée sur l'utilisation d'un processeur récent, d’architecture RISC-V et elle permet de faire du prototypage rapide et/ou d'aller jusqu'à l'implémentation physique sur FPGA ou ASIC. Cette flexibilité en fait un bon candidat comme outil pédagogique.
Systèmes intelligents pour l'internet des objets
Authors: Grisolia J. , Lachaize S. , Noullet J-L. , Biganzoli A. , Rouabhi C. , Tan R. , Guérin F. , Capello C. , Bourdeu d'Aguerre P. , Gessinn F. , Respaud M.
Published: October 2019

L'INSA de TOULOUSE propose plusieurs parcours transverses pluridisciplinaires en année terminale de formation d'ingénieur. L'un d'eux porte sur l'innovation dans le domaine des technologies de l'internet des objets - Innovative Smart Systems. Les étudiants sont formés à l'innovation, au travers de cours et d'un projet semestriel sur les différentes phases de la démarche : la conception, la mise en oeuvre, la propriété intellectuelle et à la commercialisation d'un «système intelligent». Ainsi, une large part de l'enseignement est dédiée à un projet avec une partie pratique visant à construire un capteur chimique communiquant à base de nanoparticules élaborées par voie chimique. L'ensemble de la démarche d'innovation et le capteur sont présentés devant un jury composé d'industriels du secteur.
Application de la technologie FDSOI pour la conception de nouvelles topologies de circuits analogiques et mixtes
Authors: Jacquemod G. , Charlon Y. , Wei Z. , Leduc Y. , Lorenzini P.
Published: October 2019

Pour poursuivre la loi de Moore avec des noeuds technologiques de 22 nm et en deçà, les transistors MOS bulk ont été remplacés par des transistors FinFET ou UTBB-FDSOI. Ces derniers disposent d’une grille arrière permettant de réaliser de nouvelles topologies de circuits analogiques et mixtes, offrant des performances jamais atteintes et réduisant certaines limitations, comme par exemple celles liées à la réduction de la longueur du canal. Partant de la caractéristique de la tension de seuil d’un transistor UTBB-FDSOI en fonction de la polarisation de la grille arrière, nous proposons aux élèves-ingénieurs d’étudier quelques nouvelles topologies de cellules par des simulations statiques et transitoires, associés à des analyses de Monte Carlo pour évaluer l’impact des variations du procédé de fabrication sur leurs performances finales. La première étude concerne la réalisation d’un inverseur en logique complémentaire basé sur le couplage croisé des grilles arrières de deux inverseurs permettant une symétrisation des signaux de sortie complémentaires. Ce concept peut être étendu à toutes les portes logiques et permet de réaliser des oscillateurs en anneau aux performances inédites. Une approche similaire est également appliquée à un miroir de courant permettant de réduire de façon drastique les effets de canal court.
Développement d’un traceur de caractéristiques de quadripôles et son utilisation en séance de travaux pratiques
Authors: Guérineau D. , Fache L. , Aupetit-Berthelemot C. , Medrel P.
Published: October 2019

Dans le cadre d’un projet d’études techniques, deux étudiants en 2ème du cycle ingénieur à l’ENSIL-ENSCI à Limoges ont réalisé un traceur automatique de caractéristiques de transistors (à effet de champ et bipolaire). Cet outil permet aujourd’hui aux étudiants en travaux pratiques d’électronique analogique de disposer des caractéristiques courant-tension et des paramètres dynamiques petit signal basse fréquence réalistes du composant utilisé en séance lors de la synthèse de leur circuit afin de répondre au cahier des charges spécifié. Ce papier présentera d’une part la construction de ce traceur de caractéristique (matériel utilisé, éléments de programmation …) et d’autre part l’utilisation de ces courbes lors de la synthèse d’un circuit amplificateur de tension à base d’un transistor bipolaire.
A thermal control methodology based on a predictive model for indoor heating management
Authors: Abdellatif Makram , Chamoin Julien , Defer Didier
Published: October 2019

This paper presents a thermal control methodology based on an indoor temperature predictive model that regulates heating systems. Future indoor temperature is predicted from historical data of indoor temperature and other outside parameters. A control strategy is defined afterwards in order to retrieve the optimal parameters. The building simulation shows that the developped methodology provides satisfactory results by avoiding overheating and underheating periods and thus improving the thermal comfort and the energy consumption.
Prediction of water consumption using Artificial Neural Networks modelling (ANN)
Authors: Farah Elias , Abdallah Amani , Shahrour Isam
Published: October 2019

This paper presents an application of Artificial Neural Network models (ANN) to predict the water consumption at two scales: i) District Metered Area (DMA) located in the Scientific Campus of Lille University and ii) End user representing a restaurant inside this DMA. Data are collected from Automated Meter Readers (AMRs) that measure in near real-time the water consumption. The models are trained at both daily and hourly time intervals using historical values and the variation between the hour and the type of days. The paper shows that the ANN-based models can well predict the water consumption including peak values.
Progresses on the intelligent construction and operation maintenance of urban under-lake tunnels
Authors: Wang Jingfeng , Liu Guang , Ding Zhaodong , Bian Hanbing , Yao Huayan
Published: October 2019

China is currently at an important stage of urbanization. In recent years, the number and scale of under-lake tunnels in southern cities of China are growing consistently, which brings opportunities and challenges in intelligent construction and operation maintenance. Due to the long length of the under-lake tunnel, the large volume of concrete to be cast, the complex environment of the buried section and the underground environment of the lake bottom, the hydration heat and stress crack have been the main challenges of the under-lake tunnel engineering in crack control and waterproofing aspect. Simultaneously, with the development of big data, intelligent construction, information technology, and other techniques, these techniques are gradually applied to the whole life cycle of tunnel engineering including survey, design, construction, operation, and maintenance. The construction of the lake tunnel project is setting off a new round of technological innovation. This paper systematically summarizes the technical breakthroughs and application of technologies such as intelligent construction and information technology in the construction of under-lake tunnels in China, and puts forward reasonable suggestions on the key technologies of intelligent construction and operation maintenance for urban under-lake tunnel engineering.
Comparison of M5 Model Tree and Nonlinear Autoregressive with eXogenous inputs (NARX) Neural Network for urban stormwater discharge modelling
Authors: Khalid EL GHAZOULI , Jamal EL KHATABI , Isam SHAHROUR , Aziz SOULHI
Published: October 2019

This paper presents a comparative study of two data-driven modelling techniques in forecasting urban drainage stormwater discharge based on rainfall prediction. Both M5T and NARX (Nonlinear Autoregressive with eXogenous inputs) Neural Network are used for 30 minutes storm water forecasting. Data are collected from watershed area of 3315 ha, located in the city of Casablanca in Morocco. The results show that both models provide good results, but however with better performances of the NARX model.
Application and Development of Smart Mine in China
Authors: Xu Ying , Wei Junqiang , Zhou Xiekang , Sun Feng
Published: October 2019

The development of coal mining from ancient times to today has experienced the artificial stage, the mechanized mining stage, and the automated mining stage. Now it is developing towards a safer, greener and more efficient unmanned and smart mine. This article suggests that the development of smart mine is a process of continuous improvement. The overall goal of the smart mine is divided into three development stages, from the smart working face and driving face (1.0 era) to the smart of the whole mine (2.0 era), and finally to the subversion of smart mining technology (3.0 era), the state and coal enterprises have given great attention. At present, there are more than 40 mining areas to carry out smart mine construction plans, but there are still many unresolved problems; Finally, it gives a prospect for the development and realization of Smart Mine.
Optimization of sensors locations in internal stability analysis of Geosynthetic-reinforced earth retaining walls
Authors: Alhajj Chehade Hicham , Sadek Marwan , Dias Daniel , Hage Chehade Fadi , Orianne Jenck
Published: October 2019

This paper concerns the optimization of sensors locations used to monitor the geosynthetic reinforcement internal forces of a reinforced earth retaining walls. The internal stability analysis of these structures is addressed through the kinematic theorem of limit analysis combined with the discretization technique to generate the failure surface. Knowing that the majority of damages of these structures are caused by the water presence in the reinforced zone, different water table levels are considered in the study and their effects on the critical failure surface location are analyzed.