bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Faktor-Faktor Yang Mem Engaruhi Produksi Ledre Pisang Di UD. Dua Putri Dewi, Kota Malang
Authors: Charles Labis Welafubun
Published: August 2024

The  purpose  of  this  study  was  to  find  out  what  factors  influenced  the production of banana ledre and what were the most dominant factors affecting ledre production  at  UD.  Dua  Putri Dewi, Malang  City.  Independent  variables,  namely raw material costs, outpouring of labor,  total wages and the dependent variable is the amount of ledre banana production. The analysis used in this study uses multiple regression  analysis  because  to  determine  the  effect  of  each  variable  production factor. The research variables are raw material costs, labor outlays, and total wages. To find out the effect of each factor of production variables, F test and t test (0,05) were conducted and to find out which dominant production factors were influential, a coefficient  regression test was carried out.
The  results  of  analysis  F  test  calculated  =  6.896  >  Ft abel   =  2.87  or significantly Fhit ung  = 0.001 < 0.05, meaning H0  is rejected and H1  is accepted. This shows together there is a significant influence of production factors on the amount of ledre banana production in UD. Dua Putri Dewi, Malang City. The results of the t-test analysis of the factors of production of raw material costs thit ung = 2.925 > tt abel = 0.68223, outpouring of labor thit ung = 3.142 > tt abel  = 0.68223, and the number of wages  thit ung  = 0.161 > tt abel  = 0.68223. The factors of production of raw material costs and outpouring of labor have a significant effect on ledre production at a 95% confidence  level.  The  factor  of  production  of  wage  amount  does  not  have  a significant effect  on  the amount  of ledre production  at  the 95%  confidence  level because of the sig value. production factor greater than 0.05.
Analisis Efisiensi Produksi Jagung (Zea Mays L.) Di Desa Pagak, Kecamatan Pagak, Kabupaten Malang
Authors: Stefanus Ronaldo Putera Edison
Published: August 2024

Based on the regression analysis, the R square value is 0.925, which means the amount of corn production as much as 92,5% is influenced by the variables studied and the remaining 7,5% is influenced by other variables. For the F , the calculated F value is 45,617 which is greater than the F table 2,42. This shows that all independent variables are the number of seeds (X1), ZA fertilizer (X2), urea fertilizer (X3), NPK fertilizer (X4), pesticides (X5), outpouring of work (X6), and total costs (X7). For the t test, the production factor that has a significant effect is the number of seeds (X1) and the amount of NPK fertilizer (X4) because t count of each of these variables is greater than t table. In addition, other production factors have no significant effect because t count is smaller than t table.
Kara Para Aklamaya Dair Bir Olay Çalışması: Deutsche Bank Örneği
Authors: Canöz İsmail
Published: August 2024

Bu makale, kara para aklama ile ilgili işletme skandallarını Deutsche Bank örneği üzerinden incelemeyi ve bu suçların duyurulmasının ilgili bankanın hisse senedi performansı üzerindeki etkisini araştırmayı amaçlamaktadır. 31 Ocak 2017 ile 25 Eylül 2023 tarihleri arasında bankanın dahil olduğu altı kara para aklama vakası tespit edilmiştir. Bu olaylardan üçü bankaya uygulanan para cezalarını, ikisi bankanın ödemeyi kabul ettiği cezaları ve biri de bankanın genel merkezine yapılan baskını içermektedir. Bu haberlerin ilanının ve bunlara uygulanan cezaların bankanın hisse senedi fiyatlarını olumsuz etkileyip etkilemediği, anormal getiriler hesaplanarak araştırılmıştır. Anormal getirilerin hesaplanmasında düzeltilmiş getiri modeli kullanılmıştır. Olay tarihinden önceki ve sonraki 1, 3, 5, 10 ve 15 günlük olay pencereleri belirlenmiş ve bu olay pencereleri için kümülatif anormal getiriler hesaplanmıştır. Kümülatif anormal getirilerin istatistiksel anlamlılığını değerlendirmek için standart bir t-testi uygulanmıştır. Çalışma bulguları, bankanın merkez binasına yapılan baskın ile ilgili olayın diğerlerinden açıkça farklı olduğunu ve hemen hemen her olay penceresinde bu olayın duyurulması ile negatif ve anlamlı kümülatif anormal getirilerin ortaya çıktığını göstermiştir. Ancak her kara para aklama duyurusunu takip eden günlerde olumsuz bir fiyat tepkisi olduğuna dair kanıt elde edilememiştir. Bu bulgular, hisse senedinin dolaşımda olduğu piyasanın etkinliğinin dönemsel olarak değiştiğini göstermektedir. Bu çalışmanın bulguları, bu tür skandalların borsa üzerindeki etkisine ışık tutması açısından önemlidir.
Neoliberalisation through naming: place naming and shifting modes of housing production in Ankara
Authors: Bayatlı Semire , Batuman Bülent
Published: August 2024

Place names play an important role in neoliberal urban development. The naming of a housing estate, especially a gated community, is instrumental in constructing the image and intended sense of community of an estate. This paper scrutinises the naming of housing estates in Incek, one of the most prestigious suburbs of Ankara, Turkey. While development in the area began with middle-class housing cooperatives, today Incek is marketed as an idyllic landscape embodying high-rise luxurious gated communities. We show that the naming of the housing estates not only reflects but also contributes to the shift in the mode of production from housing cooperatives to gated communities built and marketed by large-scale companies. Additionally, the name Incek has come to refer to not only the official boundaries of the neighbourhood but a larger territory, which illustrates the unfixed nature of toponyms in terms of location. Finally, the paper shows that there is a reciprocal relationship between the toponym and the image of a particular district, which can affect the functions and activities that flourish within it.

This article was published open access under a CC BY licence:
https://creativecommons.org/licences/by/4.0
.
Living through the future: rural youth, livelihoods and the production of gendered aspirations in Addis Ababa, Ethiopia
Authors: Dessie Elizabeth
Published: August 2024

This paper explores the relationship between the everyday livelihood practices of rural youth living and working in Addis Ababa and the production of gendered future aspirations. Drawing on Appadurai’s (2004) notion of the ‘capacity to aspire’ and building on theoretical advancements on youth aspirations, findings presented show young people’s future imaginaries are rooted in the driving factors that defined their migration trajectories, renegotiated in relation to subjective experiences of urban life. In highlighting the strategies that youth devise in their efforts to
survive
and
live through
the city, this paper highlights the relational nature of aspirations, emphasising how future imaginaries are formed in relation to youth’s past, their social obligations, their networks and their marginality in relation to the state. This paper situates the production of future aspirations within broader social, economic and migratory spatialities and temporalities that configure young people’s gendered experiences of cities of the global South.

This article was published open access under a CC BY-NC-ND licence:
https://creativecommons.org/licences/by-nc-nd/4.0
.
Les archives des Chalon aux Archives départementales du Nord
Authors: Donetzkoff Alexis
Published: August 2024

Les archives de l’ancienne Chambre des Comptes créée à Lille par les ducs de Bourgogne en 1386 et active jusqu’à la conquête française en 1667 sont une mine d’informations sur les grandes familles qui gravitaient autour des ducs et des Habsbourg qui leur ont succédé. Pour s’orienter au sein de ce fonds considérable, le travail des archivistes qui se sont succédé de la fin du xviii e siècle au début du xx e nous laisse une quantité remarquable d’instruments de recherche imprimés et manuscrits.
Marcher contre l’inaction climatique
Authors: Gaborit Maxime , Le Lann Yann , Solnon Anaëlle , Touzet Hugo
Published: August 2024

Entre 2018 et 2019, les manifestations et « grèves » étudiantes et lycéennes pour lutter contre le dérèglement climatique se sont multipliées et se sont imposées au cœur de l’actualité politique. Aux côtés d’autres types d’actions, ces mobilisations témoignent de la permanence des formes classiques de l’action collective. Face à ce qui s’apparente à un nouveau cycle dans l’histoire du militantisme écologiste, les enquêtes récentes se sont centrées sur les modes d’action les plus engagés (blocages, occupations…). Cet article se présente comme une contribution visant à éclairer des mobilisations plus massives, à partir de données quantitatives, afin de rendre compte des continuités et des évolutions quant aux profils sociaux et politiques des manifestant·es engagé·es sur les questions environnementales. Sur la base de questionnaires administrés au cours de quatre journées d’action, nous proposons une analyse du profil sociodémographique des personnes mobilisées mais aussi de leur rapport au politique. À distance des analyses qui en font un « mouvement de jeunes », désidéologisé ou désactivant les anciens clivages politiques, nous montrons que ces mobilisations recrutent dans les segments de la population historiquement investis sur l’écologie, tout en déplaçant les modes d’action privilégiés. Pour autant, loin d’être unifié, une étude de la composition du mouvement par les variables lourdes articulées entre elles peut permettre de comprendre la logique des oppositions internes au mouvement. Si le mouvement semble caractérisé par l’importante participation du salariat qualifié (et de leurs fils et filles) et l’ancrage à gauche, de petites distances sociales sont notables et contribuent à l’explication des clivages politiques et du renouvellement des types d’engagements, collectifs comme individuels.
Plasma electrolytic oxidation (PEO): An alternative to conventional anodization process
Authors: Lucas Rafael R. , Sales-Contini Rita C.M. , da Silva Francisco J.G. , Botelho Edson C. , Mota Rogério P.
Published: August 2024

Due to the need to develop methods that optimize the surface properties of lightweight alloys such as aluminum, titanium, and magnesium and align with contemporary requirements of the 21st century, such as enhanced environmental and sanitary efficiency, the plasma electrolytic oxidation (PEO) process stands out as a comprehensive solution. This process can develop oxide coatings on the mentioned alloys, which exhibit superior physical and chemical properties compared with conventional methods. Since 2010, research in this area has been conducted with real-world applications. Recent studies have adopted experimental design approaches to optimize parameters to reduce operational costs and make the technology more accessible. The present study conducted a comparative analysis between treatments performed by conventional methods and by plasma processes, highlighting the most promising results.
Unveiling Perimenopause
Authors: Chugh Mitali
Published: August 2024

The perimenopausal transition presents significant challenges to women's physical and psychological well-being, necessitating a thorough understanding of its symptoms. A woman's overall well-being can be greatly impacted by the physical and psychological symptoms of the perimenopausal transition, which is a significant phase in their life. Statistical analysis and interpretation of the data are crucial for developing an in-depth comprehension of these symptoms. This chapter explores the application of advanced statistical analysis to shed light on perimenopause symptomatology. Beginning with an overview of research challenges, including subjectivity and variability, the chapter elucidates various statistical techniques essential for symptom exploration. Real-world examples illustrate the practical use of these techniques, facilitating improved healthcare for women during this pivotal life stage.
Difficulties in Extracting Symptoms During Perimenopause
Authors: R. Poorvi , G. A. Sneha , M. K. Nikitha , Kachhi Zidan
Published: August 2024

Perimenopause is a phase in a woman's life that marks the end of reproductive years and is characterized by a range of physical and psychological symptoms. However, accurately identifying and extracting these symptoms poses a complex challenge for healthcare professionals. This chapter delves into the various difficulties involved in capturing the diverse experiences of women during perimenopause. The complexity is compounded by factors such as the variability in symptom presentation, the subjective nature of experiences, the societal normalization of certain symptoms, and cultural influences that affect reporting behaviours. Despite the availability of standardized questionnaires, medical history assessments, and diagnostic techniques, there is still a need for a comprehensive and individualized approach to symptom extraction. Understanding and addressing these difficulties is critical to improving the accuracy of assessments, facilitating customized interventions, and ultimately enhancing the quality of care for women navigating the complexities of perimenopause.
Towards a Green Revolution
Authors: Jain Rahul
Published: August 2024

The United Arab Emirates (UAE) stands at the crossroads of Industry 6.0 and the evolution of smart banking services, presenting a unique opportunity for a sustainable revolution. This chapter explores the synergies and challenges in achieving a green integration of Industry 6.0 technologies and smart banking services in the UAE. With a focus on sustainability, the study delves into energy-efficient manufacturing processes, sustainable supply chain management, and innovative practices within Industry 6.0. Simultaneously, it investigates carbon-neutral banking transactions, user-centric design, and data management in the realm of smart banking. Through a combination of literature review, case studies, and empirical research, the chapter identifies integration challenges, proposes policy recommendations, and envisions the future trajectory of sustainable Industry 6.0 and smart banking. By shedding light on this intersection, the research aims to contribute to a holistic understanding of how technology, industry, and finance can collectively propel the UAE towards a green revolution.
Artificial Intelligence and Internet of Things Roles in Sustainable Next-Generation Manufacturing
Authors: Shafik Wasswa
Published: August 2024

This chapter examines the influence of technology, specifically artificial intelligence (AI) and the internet of things (IoT), on contemporary industry, sometimes referred to as Industry 6.0. The text explores the practical uses of networked devices in several fields, including smart manufacturing, where they are employed for tasks such as automation, enhancing quality, and monitoring in real-time. The growing concepts of edge computing, which involves processing data in close proximity to its origin, and digital twins, which are virtual models used for simulating and optimizing processes, are being addressed. The chapter highlights advantages such as enhanced productivity, while also acknowledging obstacles such as data protection and the requirement for competent workforce. In conclusion, it underscores the significance for firms to embrace these technologies in order to stay competitive in a swiftly changing industry.
The Prospect and Challenge of Energy Transition Through Electric Vehicle Development in Indonesia
Authors: Nugraha Ubaidillah , Hermawan Marko S.
Published: August 2024

Under the Paris Agreement, Indonesia committed to reducing emissions by 32% by 2030 and achieving a net-zero emissions goal by 2060. To fulfil energy transition goals, Indonesia plans to increase the contribution of renewable energy to 23% of the country's energy by 2025, increasing from 9% in 2020. One of the catalysts for the clean energy transition is the development of the electric vehicle (EV) industry, which uses low carbon and reduces greenhouse gas emissions. Indonesia has an advantage in this area because of its position as the leading global producer of nickel as a raw material for batteries needed by electric vehicles. The complication from a sustainable development perspective is that nickel exploitation, on the one hand, will accelerate economic growth but, on the other hand, potentially contribute to the degradation of ecology and human rights protection. This book chapter describes EV prospects, analyzes the trade-off between these two conditions, and then proposes some recommendations
Streamlining Operations Insights and Innovations From the Gulf Cooperation Council (GCC)
Authors: Tariq Muhammad Usman
Published: August 2024

The chapter examines the challenges, innovations, and best practices that shape the operational strategies of this thriving economic bloc. It combines theoretical concepts with real-world case studies to provide valuable insights to educators and learners into the complexities of operational management in the GCC. The carefully curated case studies offer an in-depth understanding of the operational hurdles faced by GCC organizations and the innovative solutions implemented to overcome them. The chapter also highlights significant trends, future opportunities, and strategic implications for operations management theory and practice in the GCC context. By focusing on operations management, the chapter aims to bridge theoretical knowledge with practical application, enhancing students' analytical skills and problem-solving capabilities in this essential business domain. Ultimately, this chapter serves as a valuable resource for academic communities, practitioners, and policymakers seeking to navigate and optimize their operations in the ever-evolving GCC market.
Estimation of economic equations as a management tool in feedlot dairy farming
Authors: Sousa Flávio Vieira de , Santana Junior Hermógenes Almeida , Santana Elizângela Oliveira Cardoso , Mendes Fabrício Bacelar Lima , Souza Breno Silva e , Silva Alice Bernardo da
Published: August 2024

The aim of this study was to evaluate Pearson's linear correlations between productive and economic indicators as well as to estimate economic equations as tools in dairy farming. We used the database of the Research Group, registered with CNPq under the title ‘Animal and Forage Production in Piaui’, which consisted of two experiments with feedlot lactating cows. Economic and productive indicators were employed. Correlations were determined by Pearson’s linear correlation analysis, using the ‘t’ test. Equations were estimated via regression, using Saeg software (Statistical and Genetic Analysis System), considering α = 0.05. Based on concepts related to Pearson's linear correlation and dairy farming management, we were able to find correlations that allowed us to estimate simple, yet very informative equations, which facilitated the interpretation of the management of a dairy farm. Among the studied variables, net present value, internal rate of return, the cost per liter of milk produced and net margin were those which most contributed to the estimation of equations.
Biochemical and hematological characterization of pirarucu (Arapaima gigas Schinz, 1822) juveniles fed with different nutritional feeding systems
Authors: Hashimoto Alexandre Junior , Rocha Ana Sabrina Coutinho Marques , Hurtado Fernanda Bay , Viana Geysa Almeida , Medeiros Ivan Dias de , Porto Marlos Oliveira , Dantas Filho Jerônimo Vieira , Cavali Jucilene
Published: August 2024

The aimed of this study was to evaluate the influence of dietary protein levels on the biochemical and hematological parameters of pirarucu (Arapaima gigas). A total of 60 pirarucus specimens were used with an initial average weight of 499 ± 36 g and an initial average length of 40.30 ± 10.10 cm, stocked with densities of four pirarucus per fish tank network 48 m2 of water surface. Feed was provided three times a day (8 am, 1 and 6 pm), with five different levels of crude protein (CP) in diet: 34, 36; 38 and 40 and 45% CP. The fish were euthanized at 310 experimental days with an average of 8.0 ± 1.0 kg of body weight. Blood samples were collected by tail vessel venipuncture, divided into two aliquots 2 mL and used for determination of biochemical levels and blood count. The results were submitted to analysis of variance and regression for CP levels, with the results showed as averages followed by the standard deviation. Orthogonal contrasts were applied to verify linear and quadratic effects at 5% significance. It was observed that the parameters referring to the blood count, given by erythrocytes, hemoglobin, packed cell volume, MCV, HCM, CHCM, glucose and total proteins showed no differences between the different diets. The average values of total proteins were 3.80 ± 0.30 g L-1, glucose and triglycerides shown averages 43.45 ± 5.65 and 56.98 ± 5.80 mg dL-1, respectively. The maximum cholesterol level 120.00 ± 13.33 mg dL-1 was obtained at the 35.4% CP level in the growth phase. Protein levels in diet influenced the cholesterol levels in the pirarucu growth phase, however, they did not influence the other biochemical and hematological parameters.
Self-capacity building of small-scale buffalo farmers in pemalang regency Indonesia
Authors: Muatip Krismiwati , Safitri Lis , Cahyo Danang Nur
Published: August 2024

This study aims to determine a model for improving the self-capacity of small-scale buffalo farmers in Pemalang Regency, Indonesia. Primary data was collected from buffalo farmers in Pemalang Regency through a survey. Sub-districts were randomly selected as many as 4 out of 14 sub-districts. Two villages were selected for each sub-district. Each selected village was taken as a census respondent. A total of 226 respondents were obtained. The analysis used in this research is descriptive and Structural Equational Modeling - Partial Least Square (SEM PLS) analysis. The study results show buffalo farmers in Pemalang Regency have low to moderate self-capacity so that the number of livestock owned is relatively fixed yearly to raise livestock as savings and social status. Farmers' self-capacity must be improved by training and counselling through farmer groups. Access to capital and access to information affects farmers' skills in marketing, provision of feed, and handling of livestock reproduction.
Supplementation strategies for crossbred steers on Brachiaria brizantha pasture during the dry season: Effects on performance, intake, digestibility and ingestive behavior
Authors: Carvalho Venicio Macedo , Silva Robério Rodrigues , Lins Tulio Otávio Jardim D`Almeida , Barroso Daniele Soares , Rocha Tarcísio Ribeiro , Silva João Wilian Dias da , Santos Marceliana  da Conceição , Almeida Kleves Vieira de , Prado Ivanor Nunes do
Published: August 2024

Supplementation strategies have been studied to increase animal performance and the quality of meat. Thus, this study was carried out to evaluate the influence of different supplementation strategies on the performance, feed intake, digestibility and ingestive behaviour of crossbred steers on Brachiaria brizantha pasture, during the dry season. The experiment was performed in Bahia, Brazil, from August 2015 to January 2016, with a dry season of 203 days. Thirty-three crossbred steers with an average weight of 269.5 ± 41.8 kg were distributed in a completely randomised design with three treatments and 11 replicates per treatment. The results were analysed using an ANOVA and a Tukey test, with a 5% probability of error. The treatments were mineral salt with urea and the supplementation of protein based on the animals’ body weight (BW), as follows: 0.1 and 0.2% BW. There was no effect of supplementation strategy on the initial and final body weights. Supplementation strategies did not influence (p > 0.05) the variables related to the intake of total dry matter. There was an effect (p < 0.05) on the dry matter and crude protein digestibility coefficients. For ingestive behaviour, feed intake, grazing time and idle time tended to be altered by the supply strategies (p < 0.05), but rumination was not affected (p > 0.05) by the evaluated strategies. In conclusion, the supplementation strategies used during the dry season resulted in a similar performance; therefore, the adopted strategy can be chosen according to the economic and regional conditions of the production system. Thus, the strategy adopted could be chosen according to the economic and regional conditions of the production.
Examining Demographic and Clinical Traits in Neurofibromatosis Type 1 Patients: Insights into Vitamin D Levels and Connections with Nevus Anemicus and Neurofibromas
Authors: Ahmadi Vahid , Karimi Nazli , Evans Arsoy S. , Karaduman Ayşen
Published: August 2024

Aim:

This article aims to examine the demographic and clinical traits of neurofibromatosis type 1 (NF1) patients, particularly focusing on the potential links between vitamin D levels, BMI, and dermatological features.

Methods:

A retrospective review of medical records involving 128 patients diagnosed with neurofibromatosis type 1 (NF1) over a 3-year-period was conducted. The analysis emphasized investigating the demographic and clinical characteristics of the patients while evaluating key parameters.

Result:

Nevus anemicus was present in 32.8% of NF1 patients, and a significant association was found between nevus anemicus and low vitamin D levels (P = 0.001). We also observed a notable correlation between low vitamin D levels and an increased likelihood of neurofibromas (P < 0.001). Additionally, there appears to be an inverse relationship between serum vitamin D levels and the number of neurofibromas.

Conclusion:

Our study suggests a correlation between lower vitamin D levels and key dermatological characteristics in neurofibromatosis type 1 (NF1) individuals. Specifically, we observed associations with nevus anemicus prevalence and increased neurofibromas. This observation enriches NF1’s understanding, offering practical implications for patient management by emphasizing the importance of monitoring and addressing vitamin D levels.
Evidence of “Silent” Hepatitis B Virus Infection in Psoriasis, Vitiligo, and Pityriasis Rosea Cases: A Pilot Study
Authors: Supekar Ruchi , Roy Subrata , De Abhishek , Biswas Subhajit
Published: August 2024

Background:

Psoriasis (PS), vitiligo (VT), and Pityriasis rosea (PR) are chronic skin diseases often occurring as a consequence of exaggerated immune responses. These skin manifestations can be triggered as a result of the molecular mimicry between viral protein (s) and host protein (s), which could generate auto-antibodies. In addition, it can be hypothesised that skin diseases are manifestations of the reduced immunity that is observed in chronic hepatitis B virus (HBV)-infected individuals.

Aims and Objective:

To investigate the presence of HBV in PS, VT, and PR cases and Human Herpes Virus (HHV) 6 and 7 in PR cases.

Materials and Methods:

DNA extracted from healthy controls (n = 20), PS (n = 10), VT (n = 11), and PR (n = 12) were subjected to HBV-S gene-specific polymerase chain reactions (PCRs) and HHV 6-UL57 and HHV7-UL10 gene-specific PCRs. PCR products of positive samples (HBV and HHV 6 and 7 DNA) of expected length were bi-directionally sequenced using overlapping primers. Sequence identification was performed by NCBI BLAST and analysed by multiple sequence alignment. HBV DNA copy number was determined through quantitative real-time PCR. The blood samples were also tested for HBV serological markers and Interferon gamma (IFN-γ) by enzyme immunoassays.

Results:

The PCR data and Immunoassay study revealed that seven out of 12 PR, six out of 10 PS, and six out of 11 VT cases had signs of HBV infection. HHV 6 DNA was detected in four, whereas HHV 7 DNA was found in two of the 12 PR blood samples. PR6 presented the evidence of both HHV 6 and 7 co-infections.

Conclusion:

Observing the correlation of HBV with skin diseases, albeit at the pilot level, a larger study is warranted to identify HBV infection in skin disease patients. The evidence of HHV 6 and HHV 7 DNA in PR cases supports the HHV infection linkage with PR.
Protective effects of pistachio hydroalcoholic extract on morphine-induced analgesic tolerance and dependence: investigating the impact of oxidative stress
Authors: Hakimizadeh Elham , Fatemi Iman , Hassanshahi Jalal , Kaeidi Ayat
Published: August 2024

Background and purpose:

Chronic consumption of morphine (Mor) induces tolerance and dependence. This study aimed to survey the effects of pistachio extract (PX) on the induction and expression of Mor analgesic tolerance and physical dependency in mice.

Experimental approach:

Animals were randomly separated into six groups (n = 7): control, DMSO, Mor (10 mg/kg), Mor + saline, Mor + PX (10 mg/kg), and Mor + PX (100 mg/kg). Mor was injected (10 mg/kg, twice a day, s.c.) for 7 days to induce tolerance. PX was administered (10 and 100 mg/kg, orally) during the examination period. On each day and 20 min after Mor administration, a tail-flick test was done to measure the analgesic response and induction of tolerance. On day 7, naloxone (5 mg/kg, s.c.) was injected into the Mor-dependent animals to evaluate dependence, and animals were monitored for 30 min for jumping. Also, malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GPx) were assessed in the brain tissue.

Findings/Results:

Our results indicated that co-administration of PX with Mor for 7 days diminished the induction of Mor tolerance. PX administration for 7 days alongside Mor reduced the frequency of withdrawal signs in naloxone-injected animals during dependence induction. Also, Mor increased the level of MDA and decreased the activities of SOD and GPx. Treatment with PX (100 mg/kg) restored all of the mentioned abnormalities.

Conclusion and implications:

According to the results presented in this study, chronic administration of PX forbade the induction of Mor analgesic tolerance and dependency in mice.
Is Moderate-induced Hypothermia (≤33°C) of Clinical Value after Out-of-hospital Cardiac Arrest – Systematic Review and Meta-analysis of 10 Randomized Clinical Trials
Authors: Algethamy Haifa , Bahaziq Wadeeah
Published: August 2024

Background:

Uncertainty remains regarding potential benefits of induced hypothermia (IHT) after out-of-hospital cardiac arrest (OHCA). Spanning 12 meta-analyses of randomized clinical trials (RCTs) published since 2020, conclusions have ranged from IHT improving both survival and neurological outcomes, to improving neither, to increasing patient risk. In this meta-analysis, we compare IHT to 31-33°C against both no IHT and IHT to 34-36°C while trying to overcome some of the shortfalls of prior meta-analyses.

Methods:

After an extensive search of four scientific databases, steps were taken to select RCTs at low risk of bias, using the Cochrane Collaboration risk of bias tool, and otherwise appropriate for the question at hand after examining issues of concern with prior meta-analyses. Meta-analysis was performed of patients with shockable and non-shockable cardiac arrest rhythms both together and, as feasible, separately, generating odds ratios (OR) for each RCT separately and compiled for both mortality and neurological outcomes.

Result:

Ten RCTs encompassing 2129 IHT 31-33 patients and 2123 rhythm-matched controls were analyzed. Overall, no benefit for either mortality or neurological outcome was identified. However, three of six RCTs comparing IHT 31-33 against no IHT unveiled statistically-significant improvements in neurological outcomes, and compiling data from these six studies just failed to identify a significant benefit (OR=1.16, 0.98-1.36; p=0.077). Among 496 patients in whom rhythm-specific outcomes were reported, survival and good outcomes were achieved in 57.0% and 54.9% versus just 20.1% and 8.6% among those with shockable versus non-shockable rhythms, respectively.

Conclusion:

RCTs evaluating moderate IHT use after shockable OHCA remain necessary.
Precision medicine and immunotherapy advances transforming colorectal cancer treatment
Authors: Addissouky Tamer A. , El Sayed Ibrahim El Tantawy , Ali Majeed M. A. , Shuhata Alubiady Mahmood Hasen , Wang Yuliang
Published: August 2024

Background: Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. Key risk factors include lifestyle, diet, inflammation, and family history. Understanding molecular pathways underlying CRC initiation and progression is critical to guide prevention and treatment.

Purpose: This review summarizes recent advances in CRC screening, therapy, and future directions.

Main body: New stool DNA panels and blood-based assays offer non-invasive options for early CRC detection, though require further validation. Immuno- and targeted therapies matched to tumor molecular profiles have transformed metastatic CRC treatment. Pembrolizumab elicits durable responses in mismatch repair-deficient tumors, and anti-EGFR antibodies cetuximab/panitumumab improve outcomes for left-sided RAS/RAF wild-type CRC. Larotrectinib and entrectinib are highly active in NTRK fusion-positive CRC. Research focusing on new immunotherapies, leveraging the microbiome, and combining multi-omics data to enable precision medicine holds promise. Disparities across groups remain a challenge.

Conclusions: Recent therapeutic advances have significantly improved survival for metastatic CRC patients. Advances in non-invasive diagnostics, next-generation sequencing, and computational approaches will enable more sophisticated molecular profiling and tailored therapy selection. Realizing the potential of emerging immunotherapies and integrating knowledge of the microbiome remain important frontiers.
Targeting the PRMT1-cGAS-STING signaling pathway to enhance the anti-tumor therapeutic efficacy
Authors: Huang Daoyuan , Rezaeian Abdol-Hossein , Wang Jingchao , Qi Yihang , Chen Hong , Inuzuka Hiroyuki , Wei Wenyi
Published: August 2024

Activating innate immune signaling in tumor cells to enhance anti-tumor immunity and increase T cell-mediated killing is the core objective of tumor immunotherapy. PRMT1, one of the most crucial PRMTs, plays a critical role in tumor progression and innate immunity. Recent research revealed that PRMT1 can inhibit the enzymatic activity of cGAS in part through PRMT1-mediated Arg methylation, thereby suppressing the anti-tumor immune response of cells. As such, inhibiting or knocking down PRMT1 can synergistically enhance the efficacy of anti-PD-1 immunotherapy by activating the cGAS-STING signaling pathway.

Here, we provide a comprehensive description of the two key signaling components, PRMT1 and cGAS, in the PRMT1-cGAS-STING signaling pathway for therapeutic intervention to augment anti-tumor immunity. By understanding the specific physiological functions and regulatory mechanisms of PRMT1, as well as the extensive post-translational modifications (PTMs) of cGAS, we have identified several compounds and drugs that can directly target PRMT1 or cGAS, and or indirectly target PRMT1 upstream regulators or cGAS-post-translational modifying enzymes as potential means to activate the cGAS-STING signaling pathway. However, further investigation is needed on the efficacy of combining this pathway activation with anti-PD1 therapy. This review suggests that targeting the PRMT1-cGAS-STING pathway with immune checkpoint inhibitors is likely a promising approach in tumor immunotherapy.
SGLT2 inhibitors: A review article
Authors: Majumder Biswajit
Published: August 2024

In the beginning, SGLT2 inhibitors were regarded as anti-diabetic agents. But after demonstration of the cardiovascular benefit of SGLT2 inhibitors in EMPAREG-OUTCOME trial, a whole new era of heart failure therapy opened up. It became an integral part of heart failure treatment protocol. Several studies demonstrated its beneficial role in HFrEF until EMPEROR PRESERVED trail. It showed the benefit of SGLT2 inhibitors in HFpEF group of patients. It was consolidated by PRESERVED HF trial and recently concluded DELIVER trial. SGLT2 inhibitors are a single group of medication that is effective in all types of heart failure patients irrespective of their ejection fraction and diabetic status. Several mechanisms of action of SGLT2 inhibitors have been proposed that can explain its cardiovascular benefits. But still, studies to elucidate molecular and genetic mechanisms are going on which may open newer avenues of heart failure management in the future.
Diagnosis of hyperprolactinemia by single serum prolactin determination: Challenges and recommendations
Authors: Das Madhumita
Published: August 2024

Secretion of prolactin follows a circadian rhythm of secretion, and several factors play an important role in the regulation of its secretion. An accurate diagnostic evaluation is essential for the proper management of the patient, which can be accomplished through a narrow observation and critical analysis of all the prolactin results which are above the standard upper limit of normal. If the circulating prolactin level exceeds five times the upper normal limit, a single test is sufficient to diagnose hyperprolactinemia. However, mildly elevated (20–40 ng/ml) results should be confirmed with at least two tests to counteract the circadian fluctuation or other factors causing transitory elevation. Repeat analysis of circulating prolactin on a later date preferably with 2–3 samples collected at few min interval is also recommended to minimize the effect of pulsatility when the elevation of serum PRL is doubtful (may be due to venipuncture induced stress) or when results are inconsistent with the clinical features. This review article presents an overview of the biological and analytical aspects of prolactin along with the impact of stress on prolactin secretion, as well as the current approach employed to tackle the chances of misdiagnosis and overtreatment. However, to understand the exact mechanism of stress induced hyperprolactinemia and its implications, further research is required.
Myocardial work by 2 echocardiogram in different pathologies
Authors: Sánchez María E , Panno Mercedes , Urrutia Silvia , Etchegoyen Cecilia Villa , Iglesias Juliana , Gafni Anabel
Published: August 2024

Myocardial work is a new tool in echocardiography that incorporates after load to left ventricular strain, although it is a promising technique validated by invasive methods also presents some disadvantages related to the method or the complexity of the clinical case that we should know.

The objectives of this review are to mention the technical aspects of the method and the clinical application in different pathologies.
The tip of the reproductive screening iceberg: ‘Every mother and every fetus matters’
Authors: Wilson R Douglas
Published: August 2024

Introduction: This commentary expands on the routine pregnancy screening recommended during pregnancy, with genomic diagnosis and treatment following a positive fetal screening test indicating possible morbidity. Materials and Methods: Evidenced-based review article. Results/Discussion: An evidenced-based tool is identified for preconception risk assessment for maternal education; clinical service prioritization is promoted allowing for the ethnic and effective care for reproductive and pediatric care services; tertiary fetal diagnostic and treatment options are summarized; fetal therapy, as a quaternary service, is reviewed; human resource training is discussed. Fiscal considerations and barriers for fetal genomic and congenital malformation treatment are discussed. Conclusion: Prioritized healthcare service, preconception risk estimate counselling, genomic diagnosis, and fetal therapy for congenital malformations can reduce the neonatal and childhood morbidity but there may be fiscal and access to care barriers for many families.
How effective are antioxidants without fetal hemoglobin in tackling oxidative stress in sickle cell disease?
Authors: Dogonzo Yusuf Ishaya , Onyeabor Christopher Chimaobi
Published: August 2024

In our previous work titled “Antioxidative potential of foetal haemoglobin in sickle cell disease”, we reported that fetal hemoglobin correlated directly with antioxidative markers and inversely with markers of oxidative stress in sickle cell subjects. Based on our observations, we concluded that fetal hemoglobin contributes to the cellular antioxidant defense system by limiting the rate of production of reactive oxygen species. In this current report, we aim to highlight the synergy between fetal hemoglobin and the antioxidant defense system in modulating oxidative stress in sickle cell disease.
La cooperación China y el avance de los frentes extractivos en la cuenca amazónica: Una mirada a la transformación del perfil socioecológico de la Panamazonía
Authors: Urquijo Pineda Miguel Ángel , Calderón Rodríguez José María
Published: August 2024

En poco más de veinte años, América del Sur ha experimentado una serie de transformaciones profundas de su política económica, y esto se debe, en buena medida, a sus nuevas relaciones comerciales con China como gran potencia emergente. Esta nueva relación ha significado la creación y consolidación de nuevos frentes extractivos, la penetración al interior del territorio panamazónico para desarrollar proyectos de infraestructura que conectan a la región con el gigante asiático. Esto ha significado, en términos económicos, el ingreso de ingentes cantidades de recursos que mayoritariamente financiaron más de una década de proyectos progresistas en la región. Sin embargo, este proceso constituye también, la consolidación de una dinámica neoextractiva y la reprimarización de la región, la cual, más allá de ideologías, ha avanzado firme en esta nueva relación comercial y política. En este proceso, en China se experimenta un aumento acelerado de las clases medias y de un modo de vida urbano que requiere cada vez más y más recursos, con lo que se ha establecido una relación de profunda dependencia con las materias primas de la región sudamericana. Así, este artículo analiza el papel de la cooperación y sus impactos en la trasformación socioecológica de la región panamazónica.
Current Trends in Named Entity Recognition from Automatic Speech Recognition: A Bibliometric Analysis Using Scopus Database
Authors: Thu Hien Nguyen  , Tuan Linh Nguyen  , Thanh Binh Nguyen
Published: August 2024

Named entity recognition (NER) is critical for language understanding and text mining systems, such as event extraction and automatic question-and-answer systems. However, NER from automatic speech recognition (ASR) outputs remains challenging due to errors and lack of textual cues. This study aims to provide a comprehensive bibliometric analysis of research on NER from ASR, focusing on publications indexed in the Scopus database before 2024 to understand the research field. Using Biblioshiny and VOSviewer tools, this research identifies the key trends, prominent authors, and international collaborations in the research network. The results show steady growth in this research area, while conference papers are the predominant source type. Additionally, the study highlights the increasing intervention of deep learning approaches to enhance NER accuracy, suggesting potential research directions to reduce error rates, and developing more robust NER algorithms. Finally, the findings underscore the importance of cross-disciplinary collaborations to document any current challenges.
Hubungan Kepatuhan Minum Obat Dengan Rerata Glukosa Darah Sewaktu di Poliklinik Penyakit Dalam
Authors: Prabu Ageng Franciscus Asisi Gada , Subiyanto Paulus , Pujiastuti Theresia Tatik
Published: August 2024

ABSTRAK
Latar Belakang: Diabetes melitus tipe 2 merupakan penyakit dengan karateristik khas hiperglikemi kronik akibat resistensi insulin. Kepatuhan minum obat pasien DM tipe 2 dapat mempengaruhi gula darah.
Tujuan: mengetahui hubungan kepatuhan minum obat pada pasien DM dengan rerata glukosa darah Sewaktu
Metode: peneliti menggunakan metode cross sectional menggunakan Teknik sampel accidental sampling pada pasien diabetes melitus tipe 2 berdasarkan 72 populasi sesuai kriteria inklusi diperoleh 52 responden. Analisis korelasi menggunakan uji spearman
Hasil: Hasil penelitian menunjukkan jenis pengobatan pasien DM tipe 2 terbanyak 42,3% pada obat jenis oral dosis tunggal dan kombinasi. Kepatuhan minum obat menunjukan kategori kurang sebanyak 44,2%. Rerata glukosa darah responden DM tipe 2 menunjukan dalam kategori Kurang yaitu sebanyak 46,2 %. Hasil uji korelasi spearman didapatkan nilai p 0,003 (p 0,05) dan nilai koeficcient correlation sebesar -0,406
Simpulan: Terdapat hubungan yang signifikan antara kepatuhan minum obat dengan rerata kadar glukosa darah sewaktu pasien DM tipe 2 di poliklinik penyakit dalam Rumah Sakit Panti Rini Yogyakarta. Pasien dengan tingkat kepatuhan minum obat yang rendah cenderung memiliki rerata glukosa darah sewaktu yang tinggi, namun semakin tinggi tingkat kepatuhan minum obat maka rerata glukosa darah sewaktu pasien semakin rendah.
Kata kunci: Kepatuhan Minum Obat; Rerata Glukosa Darah; Diabetes Melitus Tipe  2
To Fly or Not to Fly? Why We Should Walk Our Own Climate Crisis Talk
Authors: van Witteloostuijn Arjen
Published: August 2024

After the pandemic, we quickly returned to business as usual. Many events moved back from online to offline, and the flying-around-the-globe circus was re-launched. If we take the climate crisis seriously, we should walk our own climate crisis talk to reduce our global carbon footprint, and to safeguard science’s credibility and legitimacy. The AIB could lead by example by opting for a hub-and-spoke model, combining an international and large but online annual conference with an orchestrated series of regional and small offline events. AIB can reap the opportunity to showcase how the road to greater sustainability could be paved convincingly.
Valuation Real Option for Investment Project Addition Source Supply Power in Coal Processing Plant ABC Mine Operation PT XYZ
Authors: Syaputra Dwi Chandra , Faturohman Taufik
Published: August 2024

Real options appraisal in investment projects provides a robust framework for decision-making under uncertainty, especially in the context of large-scale industrial operations. This research focuses on real options appraisal for an investment project in a coal processing plant at PT XYZ's ABC mine operation. The need for this research arises due to the inherent uncertainty of fossil energy sources, regulatory changes, and technological developments that significantly impact the viability and profitability of mining projects. The main objectives of this study are to evaluate the feasibility of different investment strategies for the ABC mine operation using real options appraisal and to determine the impact of various uncertainties on project profitability. The methodology used was a combination of qualitative and quantitative analysis, including scenario planning, sensitivity analysis, and the use of Monte Carlo simuDEFon to model the potential outcomes and risks associated with different investment options. The expected outcomes of this research include a comprehensive valuation model that incorporates uncertainties specific to the coal industry and provides actionable insights for PT XYZ's investment decisions. The model aims to decide on expansion projects with reference to constraints optimising the timing and scale of investments in ABC mine operations, thereby improving the company's ability to navigate investment project feasibility and regulatory changes.