bluuebunny/crossref_metadata_2025 huggingface dataset:
ARS: AI-Driven Recovery Controller for Quadruped Robot Using Single-Network Model
Authors: Kang Han Sol , Lee Hyun Yong , Park Ji Man , Nam Seong Won , Son Yeong Woo , Yi Bum Su , Oh Jae Young , Song Jun Ha , Choi Soo Yeon , Kim Bo Geun , Kim Hyun Seok , Choi Hyouk Ryeol
Published: December 2024

Legged robots, especially quadruped robots, are widely used in various environments due to their advantage in overcoming rough terrains. However, falling is inevitable. Therefore, the ability to overcome a falling state is an essential ability for legged robots. In this paper, we propose a method to fully recover a quadruped robot from a fall using a single-neural network model. The neural network model is trained in two steps in simulations using reinforcement learning, and then directly applied to AiDIN-VIII, a quadruped robot with 12 degrees of freedom. Experimental results using the proposed method show that the robot can successfully recover from a fall within 5 s in various postures, even when the robot is completely turned over. In addition, we can see that the robot successfully recovers from a fall caused by a disturbance.
Development of a Novel Colorimetric pH Biosensor Based on A-Motif Structures for Rapid Food Freshness Monitoring and Spoilage Detection
Authors: Wang Jiajia , Wang Huiyuan , Zhang Hongmin , Yang Shiqi , Lai Keqiang , Luan Donglei , Yan Juan
Published: December 2024

Accurate methods for assessing food freshness through colorimetric pH response play a critical role in determining food spoilage and ensuring food quality standards. This study introduces a novel unlabeled DNA sequence, poly-dA20, designed to exploit the colorimetric properties of both the single strand and the fold-back A-motif structure in conjunction with gold nanoparticles (AuNPs) under varying pH conditions. When exposed to storage temperatures of 4 °C and 25 °C, the color variations in the AuNP solution, influenced by pH level changes in mutton and sea bass samples’ different storage periods, are easily discernible to the naked eye within a minute. The ratio of UV absorption values at 527 nm and 700 nm (A527/A700) demonstrates a strong linear correlation with both the storage duration and pH of the food samples. Furthermore, a comprehensive analysis combining the total volatile basic nitrogen (TVB-N) value with the A527/A700 ratio is employed for precise assessment of food freshness. The innovative pH-responsive sensing strategy not only provides a new approach for on-site food freshness and spoilage detection systems but also serves as a valuable tool for pH-related biological detection in clinical diagnostic applications.
Movements of Juvenile Hen Harriers (Circus cyaneus) Tracked by Satellite Telemetry in Spain
Authors: Morollón Sara , Lee Simon , Urios Vicente
Published: December 2024

The Hen Harrier (Circus cyaneus) is a medium-sized raptor with a broad distribution across the Palearctic. In Spain, Hen Harrier behaviour is diverse due to being at the southern limit of its distribution, and the margins of distributions tend to show greater variability in the strategies and behaviours of animals. This study focused on juvenile dispersal, using GPS/GSM data from seven individuals to define movement patterns, compare variables between sexes, and analyse differences between the first and second years of dispersal. To analyse the movements during each annual period, six variables were considered, namely the mean distance from nest location, maximum distance from nest location, mean daily distance travelled, total distance travelled, 95% weekly kernel, and 95% total kernel. In their first year after leaving the nest, the Hen Harriers began dispersal movements on 21 August ± 34.41 days, with highly variable distances and durations among individuals. They travelled an average total of 6774.66 ± 5360.46 km over the two first years, with some significant differences between sexes and periods in terms of movement patterns, particularly in the daily and total distances travelled. Overall, the maximum distance from nest location and the total distance travelled were greater in the first year of dispersal than in the second year, indicating, as expected, an improved understanding of their environment and more efficient movements. The juvenile dispersal behaviour of the Hen Harrier is highly variable and represents the most vulnerable season for survival as the birds navigate new and unexplored territories.
The Behavioral Pattern of the Nesting Bearded Vulture (Gypaetus barbatus) on the Island of Crete
Authors: Perodaskalaki Anastasia , Xirouchakis Stavros
Published: December 2024

In the life history of avian taxa, homeothermy, egg laying and the need for rapid growth of the offspring are regarded as crucial evolutionary drivers for their social structure and the establishment of reproductive units [...]
Hysteretic Performance of Composite Damper with Yielding Reserve Stiffness
Authors: Zhang Xiaorui , Zhu Lihua , Liu Libo , Li Jialong
Published: December 2024

Previous research on composite dampers has rarely addressed the issue of large deformations of structures under limit state. However, the proposed damper in this paper takes this issue into account and could provide yielding reserve stiffness for structures, ensuring structural resilience. A composite damper with yielding reserve stiffness (YRSD), consisting of a friction unit and a metal yield unit, was proposed. Low cyclic loading tests with different energy-dissipating steel plate thicknesses and bolt preloads were carried out and experimental results were compared with that of numerical simulation. This paper focuses on the synergistic energy dissipation mechanism of the proposed damper and the effects of various factors on its hysteretic performance, including the bolt preload and thickness of X-shaped steel plates. The results show that the synergistic energy dissipation mechanism of the proposed damper is well, exhibiting the behavior of hardening post-yielding stiffness and multi-stage energy dissipation characteristics, which could provide yielding reserve stiffness for the structure. The experimental hysteresis curve of YRSD is full, indicating its strong energy dissipation capacity, and the skeleton curve of experiment is consistent with that of the theoretical model. The envelope area of the rectangular hysteresis curve of YRSD increases by 107.3% with the preload increased by 100%. When the thickness of the X-shaped steel plates is increased by 2 mm, the resistance of YRSD increases by 26.2% and the post-yield stiffness increases by 37.9%. The stiffness degradation trend of all specimens initially decreases and then increases. The energy dissipation capacity of the friction unit increases by 53.8% as the preload is doubled. The capacity of the metal yield unit increases by 31.7% as the thickness of the X-shaped steel plates is increased by 2 mm. When the energy dissipation capacities of the friction unit and the metal yield unit are close to equal, the optimal energy dissipation capacity of the proposed damper is achieved. The error of results between the numerical analysis and experimentation is less than 10%, providing a basis for the parametric analysis of similar composite damper with yielding reserve stiffness.
Thermodynamic Analysis of Cyclic Operation of On-Board Nanoporous Carbon-Based Adsorbed Methane Storage Tank with Various Thermal Control Systems
Authors: Chugaev Sergey S. , Men’shchikov Ilya E. , Shelyakin Igor D. , Strizhenov Evgeny M. , Grinchenko Alexander E. , Shkolin Andrey V. , Fomkin Anatoly A.
Published: December 2024

Thermal effects of adsorption and desorption, leading to temperature fluctuations and losses of adsorption storage systems capacity in the processes of gas charging and discharging, are the main obstacle to the wide practical application of adsorbed natural gas (ANG) technology. This work presents a numerical simulation of heat and mass transfer processes under various cyclic operation modes of a full-scale adsorption storage tank with various thermal control systems. The high-density monolithic adsorbent KS-HAM, obtained on the basis of industrial activated carbon KS-HA, was used as the adsorption material. The phase composition, surface morphology, and porous structure of the sorbents were studied. The adsorption of methane on the KS-HA adsorbent was measured. It is shown that increasing the duration of charging leads to obtaining additional capacity of the ANG system; however, the final efficiency and benefit at the end of the charging–discharging cycle are determined by the efficiency of the thermal control system and the gas-discharging mode. It has been shown that the presence of a finned thermal control system allows for charging the adsorption storage tank 3–8 times faster and provides an 8–24% greater amount of gas discharged at the discharging stage compared to the ANG system without fins.
A Rare Case of a Malignant Proliferating Trichilemmal Tumor: A Molecular Study Harboring Potential Therapeutic Significance and a Review of Literature
Authors: Abdelhammed Mokhtar H. , Siatecka Hanna , Diwan A. Hafeez , Finch Christie J. , Haskins Angela D. , Hernandez David J. , Xu Ya
Published: December 2024

Malignant proliferating trichilemmal tumors (MPTTs), arising from the external root sheath of hair follicles, are exceptionally rare, with limited documentation of their genetic alterations. We present a case of a 64-year-old African American woman who initially presented with a gradually enlarging nodule on her posterior scalp. An initial biopsy at an outside hospital suggested metastatic adenocarcinoma or squamous cell carcinoma (SCC) of an uncertain origin. A subsequent wide local excision revealed a 2.0 cm tumor demonstrating characteristic trichilemmal keratinization, characterized by an abrupt transition from the nucleated epithelium to a laminated keratinized layer, confirming MPTT. Immunohistochemistry demonstrated diffuse p53 expression, patchy CD 34 expression, focal HER2 membranous expression, and patchy p16 staining (negative HPV ISH). A molecular analysis identified TP53 mutation and amplifications in the ERBB2 (HER2), BRD4, and TYMS. Additional gene mutations of uncertain significance included HSPH1, ATM, PDCD1 (PD-1), BARD1, MSH3, LRP1B, KMT2C (MLL3), GNA11, and RUNX1. Assessments for the homologous recombination deficiency, PD-L1 expression, gene rearrangement, altered splicing, and DNA mismatch repair gene expression were negative. The confirmation of ERBB2 (HER2) amplification in the MPTT through a molecular analysis suggests potential therapeutic avenues involving anti-HER2 monoclonal antibodies. The presence of the TP53 mutation, without the concurrent gene mutations typically observed in SCC, significantly aided in this differential diagnosis.
Jamming and Spoofing Techniques for Drone Neutralization: An Experimental Study
Authors: Zidane Younes , Silva José Silvestre , Tavares Gonçalo
Published: December 2024

This study explores the use of electronic countermeasures to disrupt communications systems in Unmanned Aerial Vehicles (UAVs), focusing on the protection of airspaces and critical infrastructures such as airports and power stations. The research aims to develop a low-cost, adaptable jamming device using Software Defined Radio (SDR) technology, targeting key UAV communication links, including geolocation, radio control, and video transmission. It applies jamming techniques that successfully disrupt UAV communications. GPS spoofing techniques were also implemented, with both static and dynamic spoofing tested to mislead the drones’ navigation systems. Dynamic spoofing, combined with no-fly zone enforcement, proved to be particularly effective in forcing drones to land or exhibit erratic behavior. The conclusions of this study highlight the effectiveness of these techniques in neutralizing unauthorized UAVs, while also identifying the need for future research in countering drones that operate on alternative frequencies, such as 4G/5G, to enhance the system’s robustness in evolving drone environments.
Flight Altitude and Sensor Angle Affect Unmanned Aerial System Cotton Plant Height Assessments
Authors: Adedeji Oluwatola , Abdalla Alwaseela , Ghimire Bishnu , Ritchie Glen , Guo Wenxuan
Published: December 2024

Plant height is a critical biophysical trait indicative of plant growth and developmental conditions and is valuable for biomass estimation and crop yield prediction. This study examined the effects of flight altitude and camera angle in quantifying cotton plant height using unmanned aerial system (UAS) imagery. This study was conducted in a field with a sub-surface irrigation system in Lubbock, Texas, between 2022 and 2023. Images using the DJI Phantom 4 RTKs were collected at two altitudes (40 m and 80 m) and three sensor angles (45°, 60°, and 90°) at different growth stages. The resulting images depicted six scenarios of UAS altitudes and camera angles. The derived plant height was subsequently calculated as the vertical difference between the apical region of the plant and the ground elevation. Linear regression compared UAS-derived heights to manual measurements from 96 plots. Lower altitudes (40 m) outperformed higher altitudes (80 m) across all dates. For the early season (4 July 2023), the 40 m altitude had r2 = 0.82–0.86 and RMSE = 2.02–2.16 cm compared to 80 m (r2 = 0.66–0.68, RMSE = 7.52–8.76 cm). Oblique angles (45°) yielded higher accuracy than nadir (90°) images, especially in the late season (24 October 2022) results (r2 = 0.96, RMSE = 2.95 cm vs. r2 = 0.92, RMSE = 3.54 cm). These findings guide optimal UAS parameters for plant height measurement.
Benchmarking a Novel Particle Swarm Optimization Dynamic Model Versus HOMER in Optimally Sizing Grid-Integrated Hybrid PV–Hydrogen Energy Systems
Authors: Atteya Ayatte I. , Ali Dallia
Published: December 2024

This paper presents the development of an Artificial Intelligence (AI)-based integrated dynamic hybrid PV-H2 energy system model together with a reflective comparative analysis of its performance versus that of the commercially available HOMER software. In this paper, a novel Particle Swarm Optimization (PSO) dynamic system model is developed by integrating a PSO algorithm with a precise dynamic hybrid PV-H2 energy system model that is developed to accurately simulate the hybrid system by considering the dynamic behaviour of its individual system components. The developed novel model allows consideration of the dynamic behaviour of the hybrid PV-H2 energy system while optimizing its sizing within grid-connected buildings to minimize the levelized cost of energy and maintain energy management across the hybrid system components and the grid in feeding the building load demands. The developed model was applied on a case-study grid-connected building to allow benchmarking of its results versus those from HOMER. Benchmarking showed that the developed model’s optimal sizing results as well as the corresponding levelized cost of energy closely match those from HOMER. In terms of energy management, the benchmarking results showed that the strategy implemented within the developed model allows maximization of the green energy supply to the building, thus aligning with the net-zero energy transition target, while the one implemented in HOMER is based on minimizing the levelized cost of energy regardless of the green energy supply to the building. Another privilege revealed by benchmarking is that the developed model allows a more realistic quantification of the hydrogen output from the electrolyser because it considers the dynamic behaviour of the electrolyser in response to the varying PV input, and also allows a more realistic quantification of the electricity output from the fuel cell because it considers the dynamic behaviour of the fuel cell in response to the varying hydrogen levels stored in the tank.
Intake of Condensed Tannins (Acacia mearnsii) by Lambs in Confinement and Its Impact on Growth Performance, Rumen Environment, and Meat
Authors: Brunetto Andrei L. R. , dos Santos Ana Luiza F. , Zago Isadora , Deolino Guilherme L. , Nora Luisa , Molosse Vitor L. , Lago Rafael V. P. , de C. Machado Aline , Wagner Roger , Nauderer Jelson N. , Bissacotti Bianca F. , Kempka Aniela P. , Klein Bruna , Da Silva Aleksandro S.
Published: December 2024

This study determined whether adding condensed tannins to the diet of confined lamb improves performance, metabolism, health, and meat composition and quality. We used 24 Lacaune lambs with an average initial weight of 24.5 ± 0.24 kg. The animals were divided into 12 pens with two animals each. In the treatment group, a black wattle extract was added to the lamb concentrate (2.5 g/kg dry matter), while the control group received only the basal diet (without extract). Black wattle contained 98.6 g/kg of condensed tannin. There was no difference between the performance variables, which included weight gain, feed intake, and feed efficiency. However, the group fed on condensed tannins showed higher carcass yield and a higher percentage of linked intramuscular fat. In meat, a lower proportion of saturated fatty acids combined with higher concentrations of unsaturated fatty acids was observed in lambs of the condensed tannin group. The polyunsaturated fatty acids (PUFA) were no different; however, a higher PUFA/SFA ratio was observed in animals with condensed tannin intake, and a higher proportion of ω6 and ω3 was observed in the meat of these animals. The meat’s protein and ash content did not differ between treatments, as did the meat’s water retention capacity, color, and luminosity. Furthermore, animals that fed on condensed tannins had lower cholesterol levels and higher globulin content. The values of erythrogram variables were lower in lambs that consumed condensed tannins. More significant ruminal bacterial activity was also observed in the group receiving condensed tannins. The antioxidant effect was verified with lower thiobarbituric acid reactive species (TBARS) levels and more significant antioxidant enzyme activity. We conclude that adding condensed tannins improves carcass yield and increases the percentage of fat in the carcass, improving the fatty acid profile, which may be linked to the antioxidant effect, in addition to the health benefits of the consumer of this product.
Numerical Study of Laminar Unsteady Circular and Square Jets in Crossflow in the Low Velocity Ratio Regime
Authors: Martins Francisco C. , Pereira José C. F.
Published: December 2024

The unsteady three-dimensional flow interactions in the near field of square and circular jets issued normally to a crossflow were predicted by direct numerical simulations, aiming to investigate the effect of the nozzle cross-section on the vortical structures formed in this region. The analysis focuses on jets in crossflow with moderate Reynolds numbers (Rej=200 and Rej=300) based on the jet velocity the characteristic length of the nozzle and low jet-to-cross-flow velocity ratios, 0.25≤R≤1.4, where the jets are absolutely unstable. In this regime, the flow becomes periodic and laminar, and three distinct wake flow configurations were identified: (1) symmetric shedding of hairpin vortices at Rej=200; (2) the formation of toroidal vortices as the legs of hairpin vortices merge and the vortices roll up at Rej=300 and R≤0.67; (3) asymmetric shedding of hairpin vortices in the square jet at Rej=300 and R≥0.9, where higher-frequency hairpin vortex shedding combines with a low-frequency spanwise oscillation in the counter-rotating vortex pair. The dynamics of each of these flow states were analyzed. Power spectral density plots show a measurable increase in the shedding frequencies in Rej=300 jets with R, and that these frequencies are consistently larger in circular jets.
Evaluating the Relationship Between Gastrointestinal Bleeding and Valvular Heart Disease: A Systematic Review of Clinical Studies
Authors: Gries Jacob J. , Namjouyan Kamran , Ul Hassan Virk Hafeez , Alam Mahboob , Jneid Hani , Krittanawong Chayakrit
Published: December 2024

Background: Gastrointestinal angiodysplasia is a significant vascular anomaly characterized by dilated, tortuous blood vessels in the gastrointestinal tract. The current literature extensively documents the association between angiodysplasia and aortic stenosis, known as Heyde syndrome, characterized by the triad of aortic stenosis, GIB, and acquired von Willebrand syndrome. However, other valvular diseases, including mitral and tricuspid regurgitation, have also been implicated. This comprehensive systematic review aims to investigate the spectrum of valvular abnormalities, exploring the intricate mechanisms by which they contribute to gastrointestinal bleeding. Furthermore, it will evaluate the available surgical and nonsurgical treatment modalities, assessing their efficacy in mitigating the incidence of such bleeding. Methods: A comprehensive search of the Pubmed/MEDLINE database was conducted to identify relevant studies to retrieve relevant articles from August 2014 to August 2024. A combination of Medical Subject Heading (MeSH) terms and text words related to cardiac valvular diseases and GIB were used. MeSH terms included “gastrointestinal bleeding”, “heart valve diseases”, “hematochezia”, “heart valve prosthesis”, “bioprosthesis”, “native valve diseases”, and “mechanical valve”. Results: Forty-five papers met the inclusion criteria. Twenty-seven studies covered GIB in aortic valve disease, ten on mitral valve disease, two on tricuspid valve disease, and six on multiple valves. Conclusions: This systematic review demonstrates the association between angiodysplasia and aortic stenosis and highlights mitral regurgitation and tricuspid regurgitation as potential etiologies. Definitive management with valvuloplasty or valve replacement is vital to preventing the onset or recurrence of GIB in patients with valvular disease.
A Fistful of Mars Exploring the Role of Martian Meteorites in Cultural Heritage and Scientific Inquiry
Authors: Franza Annarita , Shehaj Xhonatan , Pratesi Giovanni
Published: December 2024

Meteorites have intrigued humanity for centuries, representing our enduring pursuit of knowledge and exploration of the cosmos’ enigmas. These celestial objects have not only influenced artistic expression and the formation of myths but have also fostered scientific inquiry. In this regard, meteorites are crucial to space research, offering valuable information about the early solar system, the formation of planets, and the development of organic compounds. Their analysis aids in deciphering cosmic processes and identifying resources that may support future space missions, making them essential for advancing planetary sciences. Meteorites are also cultural heritage items, with most known samples preserved in natural history museums. This paper deals with the Martian meteorites collected to date, focusing on NWA 16788, the largest individual Martian meteorite recovered so far.
Evaluation of Drought Tolerance and Trehalose Response in Auricularia heimuer
Authors: Sun Jian , Yao Fangjie , Lu Lixin , Zhang Youmin , Fang Ming , Ma Xiaoxu , Shao Kaisheng , Sun Xu
Published: December 2024

Auricularia heimuer is drought tolerant, but the mechanism underlying its physiological response to drought has not been systematically studied. We selected 13 strains of A. heimuer and simulated drought stress using a complete yeast medium (CYM) containing 20% polyethylene glycol (PEG), while the medium used for the control treatments did not contain PEG. Strains were cultured on a shaker incubator at 25 °C at 120 rpm for 15 days under dark conditions. The contents of soluble sugars (SS) and soluble proteins (SP), the activities of superoxide dismutase (SOD) and catalase (CAT), the content of malondialdehyde (MDA), and the biomass were measured. Between the 20% PEG treatment and the control, as well as among different strains, there were significant differences in all of the physiological indices. The tested strains were classified into the following four categories according to their membership function values: the first category consisted of the highly drought-tolerant strain A; the second consisted of the drought-tolerant strains A127 and C; the third consisted of the moderately drought-tolerant strains A124, A14, A386, A462, A184, A496, A125, and B; and the fourth consisted of the drought-sensitive strains A356 and A508. Transcriptome analysis was performed on C before and after drought stress treatment, and 1762 differentially expressed genes (DEGs) were obtained, including 798 up- and 964 down-regulated genes. Through KEGG enrichment analysis, it was found for the first time that the synthesis pathway for trehalose in A. heimuer is trehalose phosphate synthase–trehalose phosphate phosphatase (TPS-TPP), which is involved in the response of A. heimuer to drought stress. In addition, two key enzyme genes involved in trehalose synthesis, namely trehalose-6-phosphate synthase (AhTPS) and trehalose-6-phosphate phosphatase (AhTPP), were significantly up-regulated after drought stress. The trehalose content significantly increased in 11 strains after drought stress treatment. This study discovered, for the first time, that the synthesis pathway of trehalose is involved in the response of edible fungi to drought stress, thus providing a reference for the genetic improvement of A. heimuer and the selection of drought-tolerant strains, laying a theoretical foundation for the resistance breeding of other edible fungi.
Cardiac Arrhythmia: Molecular Mechanisms and Therapeutic Strategies
Authors: Okamoto Yosuke , Tsumoto Kunichika
Published: December 2024

Arrhythmias are divided into supraventricular and ventricular, depending on where they originate [...]
Directed Mutagenesis for Arginine Substitution of a Phaseolus acutifolius Recombinant Lectin Disrupts Its Cytotoxic Activity
Authors: Martínez-Alarcón Dania , Castro-Guillén José Luis , Fitches Elaine , Gatehouse John A. , Przyborski Stefan , Moreno-Celis Ulisses , Blanco-Labra Alejandro , García-Gasca Teresa
Published: December 2024

Recently, we reported that a recombinant Tepary bean (Phaseolus acutifolius) lectin (rTBL-1) induces apoptosis in colon cancer cell lines and that cytotoxicity was related to differential recognition of β1-6 branched N-glycans. Sequencing analysis and resolution of the rTBL-1 3D structure suggest that glycan specificity could be strongly influenced by two arginine residues, R103 and R130, located in the carbohydrate binding pocket. The aim of this work was to determine the contribution of these residues towards cytotoxic activity. Two rTBL-1 mutants were produced in Pichia pastoris, biochemically characterized, and cytotoxic effects were evaluated on human colorectal cancer cells (HT-29). Substitution of either of the arginine residues with glutamines resulted in significant reductions in cytotoxic activity, with losses of 1.5 and 3 times for R103 and R130, respectively. Docking analysis showed that the mutations decreased lectin affinity binding to some Epidermal Growth Factor Receptor (EGFR)-related N-glycans. Together, these findings confirm that both of the selected arginine residues (R103 and R130) play a key role in the recognition of tumor cell glycoconjugates by rTBL-1.
High Correlation Between Li+ Solvation Energy and Li+ Ionic Conductivity in Lithium Metal Battery Electrolytes
Authors: Choi Jihoon , Han Young-Kyu
Published: December 2024

In lithium metal batteries, accurately estimating the Li+ solvation ability of solvents is essential for effectively modulating the Li+ solvation sheath to form a stable interphase and achieve high ionic conductivity. However, previous studies have shown that the theoretically calculated Li+ binding energy, commonly used to evaluate solvation ability, exhibits only a moderate correlation with experimentally measured ionic conductivity (R2 = 0.68). In this study, to determine the effective theoretical descriptor for evaluating the solvation ability, Li+ solvation energy was adopted instead of Li+ binding energy, and its correlation with ionic conductivity was compared. Using a sophisticated calculation model that considers the Li+ counter anion and solvent, it was demonstrated that the tendency between the calculated Li+ solvation energies and experimentally measured ionic conductivities is highly consistent (R2 = 0.97). Therefore, Li+ solvation energy is suggested as the theoretical descriptor for evaluating solvation ability. All these findings encourage the development of effective molecular design of solvents for lithium metal batteries.
N-Acetyltyrosine as a Biomarker of Parenteral Nutrition Administration in First-Tier Newborn Screening Assays
Authors: Pickens C. Austin , Sah Samyukta , Chandrappa Rahul , Isenberg Samantha L. , Courtney Elya R. , Lim Timothy , Chace Donald H. , Lee Rachel , Cuthbert Carla , Petritis Konstantinos
Published: December 2024

Parenteral nutrition (PN) is a nutrient solution administered intravenously (IV) to premature babies. PN causes elevations of some amino acids in blood samples that are also biomarkers used in newborn screening (NBS). Therefore, PN status must be annotated by clinicians on dried blood spot (DBS) cards to reduce NBS laboratory burdens associated with potential false results; however, NBS laboratories continue to receive DBSs with misannotated PN status. N-acetyltyrosine (NAT), a water-soluble tyrosine analog used to increase tyrosine bioavailability in PN solutions, can be used as a blood-based biomarker of PN administration in NBS assays. Residual DBS specimens and manufactured DBSs were used in analyses. The assay was developed and validated using flow injection analysis tandem mass spectrometry (FIA-MS/MS) for the detection of NAT. NAT was only present in neonate DBSs with annotated PN administration and was multiplexed into first-tier newborn screening assays. NAT was highly correlated with amino acids present in PN solutions, such as arginine, leucine, methionine, phenylalanine, and valine. In our sample cohort, we determined an NAT cutoff could aid the identification of misannotated neonates administered PN. We also report the Amadori rearrangement product valine–hexose (Val-Hex) was quantifiable in neonates administered PN, which we suspect forms in the PN solution and/or IV lines. Here, we present the first known use of NAT as a biomarker of PN administration, which is currently being piloted by two U.S. NBS laboratories. NAT and Val-Hex can aid the identification of misannotated DBSs from neonates administered PN, thus decreasing false positive rates.
The Scientific Landscape of the Aging-in-Place Literature: A Bibliometric Analysis
Authors: Jamshidi Saman , Hashemi Seyedehnastaran
Published: December 2024

The world’s population is aging and, as populations age, they exhibit an increased prevalence of chronic diseases, which can reduce the independence of elderly individuals. The set of initiatives known as aging in place, a common policy response to the aging population, is preferred by both the elderly population and policymakers. Aging in place is a broad and multifaceted topic that involves multiple stakeholders and academic disciplines. A science map of the literature on aging in place can help researchers pinpoint their efforts and help policymakers make informed decisions. Thus, this study maps the scientific landscape of the aging-in-place literature. This review used bibliometric analysis to examine 3240 publications on aging in place indexed in the Web of Science. Using VOSviewer 1.6.20, it conducted various analyses, including a citation analysis and an analysis of the co-occurrence of author-provided keywords. The study identified key research areas, leading countries, institutions, and journals, central publications, and the temporal evolution of themes in the literature. Based on its keyword co-occurrence analysis, the study identified five major research-area clusters: (1) aging-in-place facilitators, (2) age-friendly communities, (3) housing, (4) assistive technologies, and (5) mental health. This study improves the understanding of the various interdisciplinary factors that have influenced the research on aging in place. By making this research more accessible, the study can help researchers and policymakers navigate the extensive information on aging in place and complex relationships more effectively.
Comparison of L L Polyethylene Glycol Plus Ascorbic Acid and Oral Sodium Sulfate Tablets for Colonoscopy Bowel Preparation
Authors: Park Jin Hwa , Kim Minjun , Hong Seung Wook , Hwang Sung Wook , Park Sang Hyoung , Yang Dong-Hoon , Ye Byong Duk , Myung Seung-Jae , Yang Suk-Kyun , Byeon Jeong-Sik
Published: December 2024

Background and Aims: A low-volume (1 L) polyethylene glycol plus ascorbic acid (PEG-A) solution and an oral sodium sulfate tablet (OST) formulation are recently introduced agents for colonoscopy bowel preparation. This study investigated the efficacy, safety, and tolerability of 1 L PEG-A vs. OST. Methods: This single-center, prospective, randomized, endoscopist-blinded study randomly assigned patients into 2 groups: 1 L PEG-A (group A); and OST (group B). Efficacy of bowel preparation was evaluated using the Boston Bowel Preparation Scale (BBPS). Tolerability and safety were investigated with a standardized questionnaire. Results: A total of 174 patients were included in the final analysis (group A, n = 92; group B, n = 82). Successful bowel preparation was achieved in 91.3% and 95.1% of patients in groups A and B, respectively (p = 0.324). Overall mean satisfaction with bowel preparation was greater among those in group B vs. those in group A (8.2 ± 1.7 vs. 6.8 ± 2.0, respectively; p < 0.001). Although abdominal distension was less common in group A than group B (3/92 [3.3%] vs. 9/82 [11.0%], respectively; p = 0.045), overall adverse events developed similarly in both groups (27/92 [29.3%] vs. 21/82 [25.6%], p = 0.583). In subgroup analysis of older patients (≥65 years of age), efficacy, overall satisfaction, and safety profiles were not different between groups A and B. Conclusions: Both 1 L PEG-A and OST demonstrated efficacy, tolerability, and safety for colonoscopy bowel preparation. OST was slightly better tolerated, whereas 1 L PEG-A resulted in less abdominal distension. Both agents were effective and safe in older patients.
Automatic Assessment of AK Stage Based on Dermatoscopic and HFUS Imaging—A Preliminary Study
Authors: Korecka Katarzyna , Slian Anna , Polańska Adriana , Dańczak-Pazdrowska Aleksandra , Żaba Ryszard , Czajkowska Joanna
Published: December 2024

Background: Actinic keratoses (AK) usually occur on sun-exposed areas in elderly patients with Fitzpatrick I–II skin types. Dermatoscopy and ultrasonography are two non-invasive tools helpful in examining clinically suspicious lesions. This study presents the usefulness of image-processing algorithms in AK staging based on dermatoscopic and ultrasonographic images. Methods: In 54 patients treated at the Department of Dermatology of Poznan University of Medical Sciences, clinical, dermatoscopic, and ultrasound examinations were performed. The clinico-dermoscopic AK classification was based on three-point Zalaudek scale. The ultrasound images were recorded with DermaScan C, Cortex Technology device, 20 MHz. The dataset consisted of 162 image pairs. The developed algorithm includes automated segmentation of ultrasound data utilizing a CFPNet-M model followed by handcrafted feature extraction. The dermatoscopic image analysis includes both handcrafted and convolutional neural network features, which, combined with ultrasound descriptors, are used in support vector machine-based classification. The network models were trained on public datasets. The influence of each modality on the final classification was evaluated. Results: The most promising results were obtained for the dermatoscopic analysis with the use of neural network model (accuracy 81%) and its combination with ultrasound scans (accuracy 79%). Conclusions: The application of machine learning-based algorithms in dermatoscopic and ultrasound image analysis machine learning in the staging of AKs may be beneficial in clinical practice in terms of predicting the risk of progression. Further experiments are warranted, as incorporating more images is likely to improve classification accuracy of the system.
Analysis of the Body Posture of Junior Kickboxers: An Observational Study
Authors: Łuniewicz-Stępniak Krzysztof , Truszczyńska-Baszak Aleksandra , Twarowska-Grybalow Natalia
Published: December 2024

Background/Objectives: The purpose of this study was to assess the body posture of kickboxing players. Methods: The study group included people training as kickboxers who actively participated in the training camp of the broad national junior team in the K1 and low-kick kickboxing leagues. The control group consisted of non-training people. The age of the study group ranged from 15 to 23 years. The ages of the control group participants varied from 14 to 20 years. A body posture test was performed by using the Moiré method, in accordance with the guidelines of the manufacturer of the Moiré 4G device. Results: The body posture test performed using the Moiré method showed statistically significant differences between the kickboxing training group and the control group. The parameters that showed statistically significant differences included the size of lordosis (KLL) and the depth of lordosis (GLL) in the lumbar spine. Higher values were observed in the kickboxing training group compared to the control group. There was no statistically significant difference between the kickboxing group and the control group in other parameters. Conclusions: The asymmetrical and flexed posture required during kickboxing training did not negatively influence the competitors’ spinal curvatures. Kickboxers had increased lumbar lordosis, which may be related to the specificity of the given discipline (stretching of the hamstrings and specific movements). This is a beneficial phenomenon that may reduce the risk of lower back pain. Kickboxing training did not affect the asymmetry of body posture in the sagittal plane.
Inhaled Anesthetics: Beyond the Operating Room
Authors: Darwish Dana , Kumar Pooja , Urs Khushi , Dave Siddharth
Published: December 2024

The development of inhaled anesthetics (IAs) has a rich history dating back many centuries. In modern times they have played a pivotal role in anesthesia and critical care by allowing deep sedation during periods of critical illness and surgery. In addition to their sedating effects, they have many systemic effects allowing for therapy beyond surgical anesthesia. In this narrative review we chronicle the evolution of IAs, from early volatile agents such as ether to the contemporary use of halogenated hydrocarbons. This is followed by a discussion of the mechanisms of action of these agents which primarily involve the modulation of lipid membrane properties and ion channel activity. IAs’ systemic effects are also examined, including their effects on the cardiovascular, respiratory, hepatic, renal and nervous systems. We discuss of the role of IAs in treating systemic disease processes including ischemic stroke, delayed cerebral ischemia, status epilepticus, status asthmaticus, myocardial ischemia, and intensive care sedation. We conclude with a review of the practical and logistical challenges of utilizing IAs outside the operating room as well as directions for future research. This review highlights the expanding clinical utility of IAs and their evolving role in the management of a diverse range of disease processes, offering new avenues for therapeutic exploration beyond anesthesia.
Peripheral and Organ Perfusion’s Role in Prognosis of Disease Severity and Mortality in Severe COVID-19 Patients: Prospective Cohort Study
Authors: Gutowski Mateusz , Klimkiewicz Jakub , Rustecki Bartosz , Michałowski Andrzej , Skalec Tomasz , Lubas Arkadiusz
Published: December 2024

Severe COVID-19 is associated with a generalized inflammatory response leading to peripheral and organ perfusion disorders. Objectives: This study aimed to evaluate the usefulness of peripheral and organ perfusion assessments in the prediction of prognosis and mortality in patients with severe COVID-19. Patients and Methods: In the first 48 h of hospitalization, peripheral perfusion (saturation, Finger Infrared Thermography—FIT; Capillary Refill Time—CRT), and the color Doppler renal cortex perfusion (RCP) were estimated in a group of 102 severe COVID-19 patients. Results: In total, 40 patients experienced deterioration and required intensification of oxygen treatment, and 24 finally died. In comparison with a stable course of the disease, patients with deterioration had initially higher WBC, CRP, AST, LDH, and CRT, but a lower oxygenation ratio and RCP. Deceased patients were older, had higher CRP, LDH, and CRT, but lower hemoglobin, oxygenation ratio, and RCP compared to survivors. In the multivariable regression analysis from perfusion parameters, only RCP and CRT were independently linked with deterioration (OR 0.002, p < 0.001; OR 1.825, p = 0.003, respectively) and death (OR 0.001, p = 0.004; OR 1.910, p = 0.003, respectively). Conclusions: Initial assessment of peripheral and organ perfusion can be helpful in identifying hospitalized severe COVID-19 patients with a higher risk of deterioration and death. Capillary Refill Time and Renal Cortical Perfusion were prognostic markers of deterioration or death. On the other hand, Finger Infrared Thermography and saturation were not statistically significant in predicting patient outcome. An RCP cut-off value below 0.127 and 0.112 [cm/s] and a Capillary Refill Time longer than 3.25 and 4.25 [s] indicate the risk of deterioration or death, respectively.
The Influence of Ultraviolet Irradiation on the Structure and Properties of Acrylonitrile Butadiene Styrene/Lignin Composites
Authors: Grishanovich Ilya A. , Shestakov Semen L. , Potashev Alexander V. , Belesov Artyom V. , Kozhevnikov Aleksandr Yu.
Published: December 2024

ABS plastic is an inexpensive material with attractive physical and chemical properties. Unfortunately, it is susceptible to degradation under UV radiation, so it limits the use of this material outdoors. In this paper, we demonstrate a low-cost approach to reduce the photodegradation of ABS plastic by using additives of kraft lignin and dioxane lignin as UV absorbers. Lignin is an abundant plant polymer, which is a waste product of the pulp and paper industry. Non-regular structure of lignin hampers its use in industry. However, there is possible use of lignin as an addition to enhance the properties of resulting materials. In this study, we obtained composites of ABS and lignin with the hot extrusion method. Adding up to 15% of lignin to ABS plastic does not have a significant negative impact on tensile properties. We irradiated the resulting composites with UV and studied the UV effects on their mechanical properties and chemical structure. Oxidative degradation was characterized by FTIR and 2D NMR methods. The results showed that small lignin additions reduced the photodegradation of ABS. The previously undescribed product of the degradation of the obtained composites was detected with the use of the set of 2D NMR spectra of the composites. We proposed a scheme for the formation of this photodegradation product based on the obtained data.
The Effects of Reverse Nordic Exercise Training on Measures of Physical Fitness in Youth Karate Athletes
Authors: Bouguezzi Raja , Sammoud Senda , Negra Yassine , Hachana Younés , Chaabene Helmi
Published: December 2024

Background: In karate, the ability to execute high-velocity movements, particularly kicks and punches, is heavily dependent on the strength and power of the lower limb muscles, especially the knee extensors. As such, this study aimed to evaluate the effects of an 8-week eccentric training program utilizing the reverse Nordic exercise (RNE) integrated into karate training compared with regular karate training only on measures of physical fitness in youth karate athletes. Methods: Twenty-seven youth karatekas were recruited and allocated to either RNE group (n = 13; age = 15.35 ± 1.66 years; 7 males and 6 females) or an active control group ([CG]; n = 14; 7 males and 7 females; age = 15.30 ± 1.06 years). To track the changes in measures of physical fitness before and after training, tests to assess linear sprint speed (i.e., 10 m), change of direction (CoD) speed (i.e., modified 505 CoD), vertical jumping (i.e., countermovement jump [CMJ] height) and horizontal jumping distance (i.e., standing long jump [SLJ]), and lower-limb asymmetry score (i.e., the difference between SLJ-dominant and non-dominant legs) were carried out. Results: The results indicated significant group-by-time interactions in all measures of physical fitness (effect size [ES] = 1.03 to 2.89). Post-hoc analyses revealed significant changes in the RNE group across all performance measures (effect size [ES] = 0.33 to 1.63). Additionally, the asymmetry score exhibited a moderate decrease from pre to posttest (∆46.96%, ES = 0.64). In contrast, no significant changes were observed in the CG across all fitness measures. Moreover, the individual response analysis indicated that more karatekas from the RNE group consistently achieved improvements beyond the smallest worthwhile change threshold across all fitness measures. Conclusions: In summary, RNE training is an effective approach to enhance various physical fitness measures besides lower-limb asymmetry scores in youth karatekas and is easy to incorporate into regular karate training. Practitioners are therefore encouraged to consistently integrate RNE training to enhance essential physical fitness components in young karatekas.
An Identification and Localization Method for 3D Workpiece Welds Based on the DBSCAN Point Cloud Clustering Algorithm
Authors: Zhou Nian , Jiang Ping , Jiang Shiliang , Shu Leshi , Ni Xiaoxian , Zhong Linjun
Published: December 2024

With the development of robotic welding automation, there is a strong interest in welding seam identification and localization methods with high accuracy, real-time performance, and robustness. This paper proposed a 3D workpiece weld identification and localization method based on DBSCAN (density-based spatial clustering of applications with noise) to realize stable feature extraction for multiple joint types. Firstly, this method employs combinatorial filtering to effectively eliminate non-target point clouds, including outliers and installation platform point clouds, which can minimize the computational load. Secondly, DBSCAN is used to classify workpiece point clouds into different clusters, which can be used for point cloud segmentation of flat workpieces and curved workpieces. Thirdly, the edge detection and feature extraction methods are used to obtain joint gap and weld feature points while combining the information of point clouds for different types of welds. Finally, based on the identification and localization of the welds, welding path planning and attitude planning are implemented. Experimentation results indicated that the proposed method exhibits robustness across various types of welded joints, including butt joints with straight seams, butt joints with curved seams, butt joints with curved workpieces, and lap joints. Meanwhile, the average error of joint gap detection was 0.11 mm and the processing time of a 90 mm straight-seam butt joint is 701.12 ms.