bluuebunny/crossref_metadata_2025 huggingface dataset:
A higher sport-related reinjury risk does not mean inadequate rehabilitation: the methodological challenge of choosing the correct comparison group
Authors: Shrier Ian , Zhao Meng , Piché Alexandre , Slavchev Pavel , Steele Russell J
Published: February 2017

Previous injury is a well-established predictor of subsequent injury in sports medicine. Some have interpreted this to mean that either our current methods of rehabilitation are inadequate or there is some permanent damage to the tissue and 100% rehabilitation is not possible. In 2011, we illustrated that these analyses and interpretations failed to account for the fact that some athletes are more prone to get injured, either physiologically, or because of their role/type of play. We suggested that the appropriate analysis would simply require using statistical methods that measured how each individual athlete’s risk changed from preinjury to postinjury.

In this paper, we revisit our recommendation and illustrate that it too would be flawed if the risk of injury changed over time independent of an injury ever occurring. This might be expected if general fitness were to decline over the season, or if the style of play changed between early season games and postseason championship games. Acknowledging that risk may change regardless of whether an injury occurred or not leads to three different general definitions of 100% rehabilitation: (1) a return to the baseline state, (2) a return to the immediate preinjury state and (3) a return to the state that would have been present had the initial injury never occurred. We guide the reader on how to estimate the risks for each definition and the assumptions that must be acknowledged.
Impact of weight loss on waist circumference and the components of the metabolic syndrome
Authors: Rothberg Amy E , McEwen Laura N , Kraftson Andrew T , Ajluni Nevin , Fowler Christine E , Nay Catherine K , Miller Nicole M , Burant Charles F , Herman William H
Published: February 2017

Objective

Central adiposity is a component of the metabolic syndrome (MetS). Little is known about the impact of medical weight loss and decreased waist circumference (WC) on the MetS. Our objective was to assess the impact of changes in WC on blood pressure, lipids and glycemia.

Research design and methods

We studied 430 obese patients enrolled in a 2-year, intensive, behavioral, weight management program. We report results for participants who completed 6-month and 2-year follow-up.

Results

Participants were 49±9 years of age (mean±SD), 56% were women and 85% were white. Baseline body mass index (BMI) was 41±6 kg/m2and baseline WC was 120±14 cm. At 6 months, BMI decreased by 6±3 kg/m2and WC by 14±9 cm. Relative change in WC was defined as the 6-month or 2-year WC minus the baseline WC divided by the baseline WC. Systolic blood pressure decreased by 8 mm Hg for the tertile of participants with the largest relative decrease in WC and by 2 mm Hg for those with the smallest relative decrease in WC (p=0.025). Similar patterns of improvement were observed in total cholesterol (−29 vs −12 mg/dL, p=0.017), low-density lipoprotein-cholesterol (−19 vs −4 mg/dL, p=0.033), and glycated hemoglobin (−1.2 vs −0.3%, p=0.006). At 2 years, BMI decreased by 5±4 kg/m2and WC by 11±11 cm and similar patterns of improvements were seen in components of the MetS. At both 6 months and 2 years, larger relative decreases in WC were associated with greater improvements in lipids and glycemia independent of sex.

Conclusions

In obese people, greater relative decreases in WC with medical weight loss are associated with greater improvements in components of the MetS independent of sex.
Evaluating investment in quality improvement capacity building: a systematic review
Authors: Mery Gustavo , Dobrow Mark J , Baker G Ross , Im Jennifer , Brown Adalsteinn
Published: February 2017

Purpose

Leading health systems have invested in substantial quality improvement (QI) capacity building, but little is known about the aggregate effect of these investments at the health system level. We conducted a systematic review to identify key steps and elements that should be considered for system-level evaluations of investment in QI capacity building.

Methods

We searched for evaluations of QI capacity building and evaluations of QI training programmes. We included the most relevant indexed databases in the field and a strategic search of the grey literature. The latter included direct electronic scanning of 85 relevant government and institutional websites internationally. Data were extracted regarding evaluation design and common assessment themes and components.

Results

48 articles met the inclusion criteria. 46 articles described initiative-level non-economic evaluations of QI capacity building/training, while 2 studies included economic evaluations of QI capacity building/training, also at the initiative level. No system-level QI capacity building/training evaluations were found. We identified 17 evaluation components that fit within 5 overarching dimensions (characteristics of QI training; characteristics of QI activity; individual capacity; organisational capacity and impact) that should be considered in evaluations of QI capacity building. 8 key steps in return-on-investment (ROI) assessments in QI capacity building were identified: (1) planning—stakeholder perspective; (2) planning—temporal perspective; (3) identifying costs; (4) identifying benefits; (5) identifying intangible benefits that will not be included in the ROI estimation; (6) discerning attribution; (7) ROI calculations; (8) sensitivity analysis.

Conclusions

The literature on QI capacity building evaluation is limited in the number and scope of studies. Our findings, summarised in aFramework to Guide Evaluations of QI Capacity Building, can be used to start closing this knowledge gap.
Interpretation and use of evidence in state policymaking: a qualitative analysis
Authors: Apollonio Dorie E , Bero Lisa A
Published: February 2017

Introduction

Researchers advocating for evidence-informed policy have attempted to encourage policymakers to develop a greater understanding of research and researchers to develop a better understanding of the policymaking process. Our aim was to apply findings drawn from studies of the policymaking process, specifically the theory of policy windows, to identify strategies used to integrate evidence into policymaking and points in the policymaking process where evidence was more or less relevant.

Methods

Our observational study relied on interviews conducted with 24 policymakers from the USA who had been trained to interpret scientific research in multiple iterations of an evidence-based workshop. Participants were asked to describe cases where they had been involved in making health policy and to provide examples in which research was used, either successfully or unsuccessfully. Interviews were transcribed, independently coded by multiple members of the study team and analysed for content using key words, concepts identified by participants and concepts arising from review of the texts.

Results

Our results suggest that policymakers who focused on health issues used multiple strategies to encourage evidence-informed policymaking. The respondents used a strict definition of what constituted evidence, and relied on their experience with research to discourage the use of less rigorous research. Their experience suggested that evidence was less useful in identifying problems, encouraging political action or ensuring feasibility and more useful in developing policy alternatives.

Conclusions

Past research has suggested multiple strategies to increase the use of evidence in policymaking, including the development of rapid-response research and policy-oriented summaries of data. Our findings suggest that these strategies may be most relevant to the policymaking stream, which develops policy alternatives. In addition, we identify several strategies that policymakers and researchers can apply to encourage evidence-informed policymaking.
Parallel contagion phenomenon of concordant mental disorders among married couples: a nationwide cohort study
Authors: Wang Jong-Yi , Hsieh Ming-Hong , Lin Pei-Ching , Liu Chiu-Shong , Chen Jen-De
Published: February 2017

Background

The aggregation of mental disorders in couples, as reported by prior research, indicates the effect of familial environments and warrants attention. However, the concordant categories of mental disorders in couples remain unclear. This study investigated spousal concordance for the category of mental disorders among couples throughout Taiwan by using factors associated with such disorders.

Methods

5643 couples in the 2002–2013 Taiwan National Health Insurance Research Database were analysed and compared with propensity-matched 5643 non-couples. Twelve independent variables, including spouse and shared characteristics, and the category of mental disorders were analysed, mainly by using multinomial logistic regression.

Results

The determined prevalence rates for concordant categories of mental disorder were 0.19% for affective disorders, 6.96% for anxiety disorders, and 3.15% of other mental disorders. Multinomial logistic regression results revealed that two spouses were significantly more likely to be diagnosed with the same category of the aforementioned mental disorders (ORs=2.914, 1.776 and 1.727, respectively). Other associated factors included gender, age, occupation, comorbidity and region. The odds of concordances were significantly higher in couples than in non-couples.

Conclusions

A category of mental disorder in one spouse is a determinant of that in the other spouse. This study extended the emotional contagion theory to the phenomenon of parallel contagion to reflect the three concordances, suggesting a direction of family-based mental health intervention, particularly prevention for the same category of mental disorders in couples. Policymakers should strengthen the coping strategies of the caring spouse and external support system to psychiatrically vulnerable families.
The availability of smoking-permitted accommodations from Airbnb in 12 Canadian cities
Authors: Kennedy Ryan David , Douglas Ornell , Stehouwer Lindsay , Dawson Jackie
Published: February 2017

Purpose

Airbnb is a web-based peer-to-peer (P2P) service that enables potential hosts and guests to broker accommodations in private homes as an alternative to traditional hotels. The hospitality sector has increasingly gone smoke-free over the last decade. This study identified the availability and cost of smoking-permitted accommodations identified on Airbnb.

Methods

The study team searched for Airbnb accommodations in 12 Canadian cities across each of Canada’s 10 provinces. Searches included availability for a single person for a private room, or double occupancy for an entire home/apartment; searches were for 1-night and 1-week stays.

Results

Cities across Canada, including Regina, Fredericton and Charlottetown, had no smoking-permitted accommodations available for the searches conducted. The proportion of private rooms available for one night that permitted smoking ranged from 2% in Calgary, 4% in Winnipeg and St. John’s, 10% in Halifax and Victoria, 18% in Toronto, 45% in Vancouver and 69% in Montréal. The average cost for a private room for one night in Vancouver was $128, while the cost for a private room that permits smoking was $62; however, in other markets prices were more similar.

Discussion

Across Canada, there is a wide range of smoking-permitted accommodations available through Airbnb. In some markets, smoking-permitted accommodation may be significantly less expensive than smoke-free options. As hotel chains increasingly go smoke-free, it is possible that the marketplace will respond with offerings to fulfil consumer demand. As policy makers consider how to regulate P2P services like Airbnb, public health considerations should be included.
Mineral status in canine medial coronoid process disease: a cohort study using analysis of hair by mass spectrometry
Authors: Davies M. , West J. , Williams C. , Gardner D.S.
Published: February 2017

In several species, developmental skeletal diseases involving abnormal endochondral ossification have been associated with imbalanced mineral intake. Hair analysis reflects long‐term mineral status. To determine the mineral content of hair from dogs with or without medial coronoid process disease (MCPD). Dogs with MCPD have a different profile of minerals known to influence metalloenzymes involved in endochondral ossification. After cleansing, chelation and acid digestion of hair samples (n=79 in total: control dogs, n=70 v MCPD, n=9), mineral profile (7 major and 25 trace elements) was determined by inductively coupled plasma‐mass spectrometry. Dogs were of similar age (control, 4.05 [1.85–7.70] v MCPD, 4.30 [3.25–6.53] median (IQR) years; P=0.78) and gender (control, n=43/27 v MCPD, n=4/5 males/females). 28/70 (40 per cent) of control and 8/9 (88 per cent) of MCPD dogs were neutered, respectively. Hair from dogs with MCPD contained significantly lower amounts (µg/g/DM) of copper, sulphur and zinc (all at P<0.001). Age, sex and neutered status had no effect on hair mineral status. Based on hair analysis, a role for mineral imbalance including copper, sulphur and zinc in the aetiopathogenesis of canine MCPD is suggested. Hair mineral analysis may prove useful as a biomarker for susceptible puppies.
Quantifying long-term population growth rates of threatened bull trout: challenges, lessons learned, and opportunities
Authors: Budy Phaedra E. , Bowerman Tracy , Al-Chokhachy Robert , Conner Mary , Schaller Howard
Published: February 2017

Temporal symmetry models (TSM) represent advances in the analytical application of mark–recapture data to population status assessments. For a population of char, we employed 10 years of active and passive mark–recapture data to quantify population growth rates using different data sources and analytical approaches. Estimates of adult population growth rate were 1.01 (95% confidence interval = 0.84–1.20) using a temporal symmetry model (λTSM), 0.96 (0.68–1.34) based on logistic regressions of annual snorkel data (λA), and 0.92 (0.77–1.11) from redd counts (λR). Top-performing TSMs included an increasing time trend in recruitment (f) and changes in capture probability (p). There was only a 1% chance the population decreased ≥50%, and a 10% chance it decreased ≥30% (λMCMC; based on Bayesian Markov chain Monte Carlo procedure). Size structure was stable; however, the adult population was dominated by small adults, and over the study period there was a decline in the contribution of large adults to total biomass. Juvenile condition decreased with increasing adult densities. Utilization of these different information sources provided a robust weight-of-evidence approach to identifying population status and potential mechanisms driving changes in population growth rates.
Using passive acoustic monitoring to document the distribution of beaked whale species in the western North Atlantic Ocean
Authors: Stanistreet Joy E. , Nowacek Douglas P. , Baumann-Pickering Simone , Bell Joel T. , Cholewiak Danielle M. , Hildebrand John A. , Hodge Lynne E.W. , Moors-Murphy Hilary B. , Van Parijs Sofie M. , Read Andrew J.
Published: February 2017

Little is known about the ecology of many beaked whale species, despite concerns raised by mass strandings linked to certain sources of anthropogenic noise. Here, we used passive acoustic monitoring to examine spatial and temporal patterns in beaked whale occurrence at six locations along the continental slope in the western North Atlantic Ocean. We analyzed 2642 days of recordings collected between 2011 and 2015, and identified echolocation signals from northern bottlenose whales (Hyperoodon ampullatus), Cuvier’s (Ziphius cavirostris), Sowerby’s (Mesoplodon bidens), Gervais’, (Mesoplodon europaeus), and Blainville’s (Mesoplodon densirostris) beaked whales, and one signal type of unknown origin. We recorded multiple species at each site, with detections generally occurring year-round, and observed latitudinal gradients and site-specific variation in relative species occurrence. Notably, we regularly detected Cuvier’s beaked whales in a region where they have not been commonly observed, and discovered potential habitat partitioning among Cuvier’s and Gervais’ beaked whales within their overlapping ranges. This information on the distribution and seasonal occurrence of North Atlantic beaked whale species offers new insight into patterns of habitat use, and provides a year-round baseline from which to assess potential anthropogenic impacts.
Synthesis and magnetic property of Eu-doped barium vanadate microflowers
Authors: Zhuo Fengping , Wang Yue , Fu Ya , Yuan Jinhai , Xu Jing
Published: February 2017

The Ba3V2O8and Ba3V2O8:Eu[Formula: see text] microflowers were synthesized by the composite-hydroxide-mediated (CHM) method from V2O5, BaCl2and Eu(NO[Formula: see text] without using any surface-capping agent. XRD, EDS and XPS spectra of the crystals indicated that Eu[Formula: see text] ions were incorporated into the Ba3V2O8lattices. The effect of doping Eu[Formula: see text] on the magnetic property of Ba3V2O8crystal has been investigated at room temperature. The Ba3V2O8:Eu[Formula: see text] crystals exhibited room-temperature ferromagnetic behavior with remanence magnetization (Mr) of about 5.411 × 10[Formula: see text] emu/g and coercivity (Hc) of 28.29 Oe. The mechanism of enhanced magnetic property of Eu-doped Ba3V2O8crystals has been discussed in detail.
Software and Hardware FPGA-Based Digital Watermarking and Steganography Approaches: Toward New Methodology for Evaluation and Benchmarking Using Multi-Criteria Decision-Making Techniques
Authors: Zaidan B. B. , Zaidan A. A.
Published: February 2017

Evaluating and benchmarking software and hardware field programmable gate array (FPGA)-based digital watermarking are considered challenging tasks because of multiple and conflicting evaluation criteria. A few evaluation and benchmarking techniques/frameworks have been implemented to digital watermarking or steganography; however, these approaches still present certain limitations. In particular, fixing some attributes on account of other attributes and well-known benchmarking approaches are limited to robust watermarking techniques. Thus, this study aims toward a new methodology for evaluation and benchmarking using multi-criteria analysis for software and hardware “FPGA”-based digital watermarking or steganography. To achieve this objective, two iterations are conducted. The first iteration consists of two stages: discussing software and hardware “FPGA”-based digital watermarking or steganography to create a dataset with various samples for benchmarking and discussing the evaluation method and then discussing the test for software and hardware “FPGA”-based digital watermarking or steganography according to multi-criteria evaluation (i.e., complexity, payload and quality) to create a decision matrix. The second iteration applies different decision-making techniques (i.e., SAW, MEW, HAW, TOPSIS, WSM and WPM)) to benchmark the results of the first iteration (i.e., software or hardware FPGA-based digital watermarking or steganography approaches). Then, the discussed mean, standard deviation and paired sample [Formula: see text]-test results are used to measure the correlations among different techniques based on the ranking results. The discussion findings are described as follows: (1) the integration of developer and evaluator preferences into the evaluation and benchmarking for software and hardware FPGA-based digital watermarking or steganography, (2) the process of assigning weights and (3) visualizing large-scale data sample in either software or hardware FPGA-based digital watermarking or steganography algorithms.
A case study: evaluating low-porosity and ultra-low-permeability Triassic reservoir rocks in the Ordos Basin by the integration of logs and core
Authors: Tan Fengqi , Zhao Rui , Zhao Yangyang , Pan Zhejun , Li Hongqi
Published: February 2017

An analysis of the characteristics of ultra-low-permeability reservoir rocks and the processes for permeability loss form the basis for establishing high-resolution well log interpretation models. Moreover, this type of analysis is a prerequisite for the effective development of ultra-low-permeability reservoirs. The Chang 7-1 sandstone members of the Triassic Yanchang Group in the Longdong region of the SW Ordos Basin are typical ultra-low-permeability reservoirs and are studied in detail in this paper. A comprehensive methodology of evaluating the ultra-low-permeability reservoir is developed based on geological information and well logging data. First, pore structure characteristics are analysed in depth using core observations, cast thin sections, scanning electron microscopy and mercury injection porosimetry. The mechanism behind the formation of ultra-low permeability in a reservoir rock, and its controlling factors, are also clearly determined. Second, from the above results and the pore structure characteristics in the study area, the flow-zone indicator (FZI) is selected as the key reservoir modelling parameter to establish permeability models that can reflect different pore structure types and improve precision compared to non-classification pore structure models. In addition, conductivity experiments with water-saturated cores confirm that the additional conduction phenomenon of clay minerals has little impact in terms of reducing reservoir resistivity and, consequently, the Archie formula is found to be reliable for ultra-low-permeability rocks with porosities greater than 5% in the Chang 7-1 reservoir. Three types of well log interpretation models, such as permeability, oil saturation and porosity, are established for the ultra-low-permeability reservoirs using FZI as a classifier in the research area. These models reduce the relative errors to less than 10% and performed well for the ultra-low-permeability Chang 7-1 sandstones. This study contributes to the evaluation of ultra-low-permeability reservoir rocks and also generates fit-for-purpose log evaluation models to guide completion interval selection.
CTRP7 deletion attenuates obesity-linked glucose intolerance, adipose tissue inflammation, and hepatic stress
Authors: Petersen Pia S. , Lei Xia , Wolf Risa M. , Rodriguez Susana , Tan Stefanie Y. , Little Hannah C. , Schweitzer Michael A. , Magnuson Thomas H. , Steele Kimberley E. , Wong G. William
Published: February 2017

Chronic low-grade inflammation and cellular stress are important contributors to obesity-linked metabolic dysfunction. Here, we uncover an immune-metabolic role for C1q/TNF-related protein 7 (CTRP7), a secretory protein of the C1q family with previously unknown function. In obese humans, circulating CTRP7 levels were markedly elevated and positively correlated with body mass index, glucose, insulin, insulin resistance index, hemoglobin A1c, and triglyceride levels. Expression of CTRP7 in liver was also significantly upregulated in obese humans and positively correlated with gluconeogenic genes. In mice, Ctrp7 expression was differentially modulated in various tissues by fasting and refeeding and by diet-induced obesity. A genetic loss-of-function mouse model was used to determine the requirement of CTRP7 for metabolic homeostasis. When fed a control low-fat diet, male or female mice lacking CTRP7 were indistinguishable from wild-type littermates. In obese male mice consuming a high-fat diet, however, CTRP7 deficiency attenuated insulin resistance and enhanced glucose tolerance, effects that were independent of body weight, metabolic rate, and physical activity level. Improved glucose metabolism in CTRP7-deficient mice was associated with reduced adipose tissue inflammation, as well as decreased liver fibrosis and cellular oxidative and endoplasmic reticulum stress. These results provide a link between elevated CTRP7 levels and impaired glucose metabolism, frequently associated with obesity. Inhibiting CTRP7 action may confer beneficial metabolic outcomes in the setting of obesity and diabetes.
Trends in the Binding of Cell Penetrating Peptides to siRNA: A Molecular Docking Study
Authors: Rathnayake P. V. G. M. , Gunathunge B. G. C. M. , Wimalasiri P. N. , Karunaratne D. N. , Ranatunga R. J. K. U.
Published: February 2017

The use of gene therapeutics, including short interfering RNA (siRNA), is limited by the lack of efficient delivery systems. An appealing approach to deliver gene therapeutics involves noncovalent complexation with cell penetrating peptides (CPPs) which are able to penetrate the cell membranes of mammals. Although a number of CPPs have been discovered, our understanding of their complexation and translocation of siRNA is as yet insufficient. Here, we report on computational studies comparing the binding affinities of CPPs with siRNA, considering a variety of CPPs. Specifically, seventeen CPPs from three different categories, cationic, amphipathic, and hydrophobic CPPs, were studied. Molecular mechanics were used to minimize structures, while molecular docking calculations were used to predict the orientation and favorability of sequentially binding multiple peptides to siRNA. Binding scores from docking calculations were highest for amphipathic peptides over cationic and hydrophobic peptides. Results indicate that initial complexation of peptides will likely occur along the major groove of the siRNA, driven by electrostatic interactions. Subsequent binding of CPPs is likely to occur in the minor groove and later on bind randomly, to siRNA or previously bound CPPs, through hydrophobic interactions. However, hydrophobic CPPs do not show this binding pattern. Ultimately binding yields a positively charged nanoparticle capable of noninvasive cellular import of therapeutic molecules.
ZNF395 Is an Activator of a Subset of IFN-Stimulated Genes
Authors: Schroeder Linda , Herwartz Christine , Jordanovski Darko , Steger Gertrud
Published: February 2017

Activation of the interferon (IFN) pathway in response to infection with pathogens results in the induction of IFN-stimulated genes (ISGs) including proinflammatory cytokines, which mount the proper antiviral immune response. However, aberrant expression of these genes is pathogenic to the host. In addition to IFN-induced transcription factors non-IFN-regulated factors contribute to the transcriptional control of ISGs. Here, we show by genome wide expression analysis, siRNA-mediated suppression and Doxycycline-induced overexpression that the cellular transcription factor ZNF395 activates a subset of ISGs including the chemokines CXCL10 and CXCL11 in keratinocytes. We found that ZNF395 acts independently of IFN but enhances the IFN-induced expression of CXCL10 and CXCL11. Luciferase reporter assays revealed a requirement of intact NFκB-binding sites for ZNF395 to stimulate the CXCL10 promoter. The transcriptional activation of CXCL10 and CXCL11 by ZNF395 was abolished after inhibition of IKK by BMS-345541, which increased the stability of ZNF395. ZNF395 encodes at least two motifs that mediate the enhanced degradation of ZNF395 in response to IKK activation. Thus, IKK is required for ZNF395-mediated activation of transcription and enhances its turn-over to keep the activity of ZNF395 low. Our results support a previously unrecognized role of ZNF395 in the innate immune response and inflammation.
Clinical Outcomes and Safety of Partial Full-Thickness Myotomy versus Circular Muscle Myotomy in Peroral Endoscopic Myotomy for Achalasia Patients
Authors: Li Chenyu , Gong Aixia , Zhang Jingwen , Duan Zhijun , Ge Linmei , Xia Nan , Leng Jing , Li Mei , Liu Yanjie
Published: February 2017

Background. Here we aimed to evaluate and compare the efficacy and safety between partial full-thickness myotomy and circular muscle myotomy during POEM procedure in achalasia patients. Methods. Clinical data of achalasia of cardia (AC) patients who underwent POEM in our center during January 2014 to January 2015 was collected (34 cases). 19 patients who received partial full-thickness myotomy were assigned to group A and 14 patients who received circular muscle myotomy were assigned to group B. The procedure-related parameters between the two groups were compared. Symptom relief rate and postprocedure manometry outcomes were compared to evaluate the efficacy. Procedure-related adverse events and complications were compared to evaluate the safety. Results. (1) Mean operation times were significantly shorter in group A than group B (62.42±23.17 vs 87.86±26.44 min, p<0.01). (2) Symptom relief rate and postprocedure manometry outcomes had no statistical differences when compared between the two groups (all p>0.05). (3) Comparison of procedure-related adverse events and complications had no statistical differences (all p>0.05). Conclusion. Partial full-thickness myotomy had no significant differences in efficacy or safety with circular myotomy, but partial full-thickness myotomy significantly reduced the procedure time.
Children’s Behavioral Pain Cues: Implicit Automaticity and Control Dimensions in Observational Measures
Authors: Sekhon Kamal Kaur , Fashler Samantha R. , Versloot Judith , Lee Spencer , Craig Kenneth D.
Published: February 2017

Some pain behaviors appear to be automatic, reflexive manifestations of pain, whereas others present as voluntarily controlled. This project examined whether this distinction would characterize pain cues used in observational pain measures for children aged 4–12. To develop a comprehensive list of cues, a systematic literature search of studies describing development of children’s observational pain assessment tools was conducted using MEDLINE, PsycINFO, and Web of Science. Twenty-one articles satisfied the criteria. A total of 66 nonredundant pain behavior items were identified. To determine whether items would be perceived as automatic or controlled, 277 research participants rated each on multiple scales associated with the distinction. Factor analyses yielded three major factors: the “Automatic” factor included items related to facial expression, paralinguistics, and consolability; the “Controlled” factor included items related to intentional movements, verbalizations, and social actions; and the “Ambiguous” factor included items related to voluntary facial expressions. Pain behaviors in observational pain scales for children can be characterized as automatic, controlled, and ambiguous, supporting a dual-processing, neuroregulatory model of pain expression. These dimensions would be expected to influence judgments of the nature and severity of pain being experienced and the extent to which the child is attempting to control the social environment.
Epigenetic Mechanisms of Integrative Medicine
Authors: Kanherkar Riya R. , Stair Susan E. , Bhatia-Dey Naina , Mills Paul J. , Chopra Deepak , Csoka Antonei B.
Published: February 2017

Since time immemorial humans have utilized natural products and therapies for their healing properties. Even now, in the age of genomics and on the cusp of regenerative medicine, the use of complementary and alternative medicine (CAM) approaches represents a popular branch of health care. Furthermore, there is a trend towards a unified medical philosophy referred to as Integrative Medicine (IM) that represents the convergence of CAM and conventional medicine. The IM model not only considers the holistic perspective of the physiological components of the individual, but also includes psychological and mind‐body aspects. Justification for and validation of such a whole‐systems approach is in part dependent upon identification of the functional pathways governing healing, and new data is revealing relationships between therapies and biochemical effects that have long defied explanation. We review this data and propose a unifying theme: IM’s ability to affect healing is due at least in part to epigenetic mechanisms. This hypothesis is based on a mounting body of evidence that demonstrates a correlation between the physical and mental effects of IM and modulation of gene expression and epigenetic state. Emphasis on mapping, deciphering, and optimizing these effects will facilitate therapeutic delivery and create further benefits.
Impact of Pressurized Intraperitoneal Aerosol Chemotherapy on Quality of Life and Symptoms in Patients with Peritoneal Carcinomatosis: A Retrospective Cohort Study
Authors: Teixeira Farinha Hugo , Grass Fabian , Kefleyesus Amaniel , Achtari Chahin , Romain Benoit , Montemurro Michael , Demartines Nicolas , Hübner Martin
Published: February 2017

Background. Peritoneal cancer treatment aims to prolong survival, but preserving Quality of Life (QoL) under treatment is also a priority. Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) is a novel minimally invasive repeatable treatment modality. The aim of the present study was to assess QoL in our cohort of PIPAC patients. Methods. Analysis of all consecutive patients included from the start of PIPAC program (January 2015). QoL (0–100: optimal) and symptoms (no symptom: 0–100) were measured prospectively before and after every PIPAC procedure using EORTC QLQ-C30. Results. Forty-two patients (M : F = 8 : 34, median age 66 (59–73) years) had 91 PIPAC procedures in total (1 : 4x, 17 : 3x, 12 : 2x, and 12 : 1x). Before first PIPAC, baseline QoL was measured as median of 66±2.64. Prominent complaints were fatigue (32±4.3) and digestive symptoms as diarrhea (17±3.75), constipation (17±4.13), and nausea (7±2.54). Overall Quality of Life was 64±3.75 after PIPAC#1 (p=0.57), 61±4.76 after PIPAC#2 (p=0.89), and 70±6.67 after PIPAC#3 (p=0.58). Fatigue symptom score was 44±4.86 after PIPAC#1 and 47±6.69 and 34±7.85 after second and third applications, respectively (p=0.40). Diarrhea (p=0.31), constipation (p=0.76), and nausea (p=0.66) did not change significantly under PIPAC treatment. Conclusion. PIPAC treatment of peritoneal carcinomatosis had no negative impact on patients’ overall QoL and its components or on main symptoms. This study was registered online on Research Registry (UIN: 1608).
Maximum Likelihood and Bayes Estimation in Randomly Censored Geometric Distribution
Authors: Krishna Hare , Goel Neha
Published: February 2017

In this article, we study the geometric distribution under randomly censored data. Maximum likelihood estimators and confidence intervals based on Fisher information matrix are derived for the unknown parameters with randomly censored data. Bayes estimators are also developed using beta priors under generalized entropy and LINEX loss functions. Also, Bayesian credible and highest posterior density (HPD) credible intervals are obtained for the parameters. Expected time on test and reliability characteristics are also analyzed in this article. To compare various estimates developed in the article, a Monte Carlo simulation study is carried out. Finally, for illustration purpose, a randomly censored real data set is discussed.
Uncovering Clinical Features of De Novo Philadelphia Positive Myelodysplasia
Authors: Armas Aristides , Chen Chen , Mims Martha , Rivero Gustavo
Published: February 2017

Myelodysplastic syndrome (MDS) is cytogenetically heterogeneous and retains variable risk for acute myeloid leukemia transformation. Though not yet fully understood, there is an association between genetic abnormalities and defects in gene expression. The functional role for infrequent cytogenetic alteration remains unclear. An uncommon chromosomic abnormality is the presence of the Philadelphia (Ph) chromosome. Here, we report a patient with Ph+ MDS treated with low dose Dasatinib who achieved hematologic response for 7 months. In addition, we also examined the English literature on all de novo Ph + MDS cases between 1996 and 2015 to gain insight into clinical features and outcome.
Clinical and Prognostic Significance of Positive Hepatojugular Reflux on Discharge in Acute Heart Failure: Insights from the ESCAPE Trial
Authors: Omar Hesham R. , Guglin Maya
Published: February 2017

Background. There has been a decline in emphasis of the value of physical examination in heart failure (HF) with increased reliance on cardiac imaging. We aim to study the clinical and prognostic significance of positive hepatojugular reflux (HJR) on discharge in patients hospitalized with HF.Methods. Using the ESCAPE trial data, patients were compared according to the presence or absence of a positive HJR on discharge. The primary study endpoints were all-cause mortality and a composite endpoint of death, rehospitalization, and cardiac transplant during the first 6 months after discharge.Results. Among 392 patients (age: 56 years, 74% men), the HJR correlated well with clinical and objective hemodynamic markers of volume overload including right atrial pressure (RAP,P=0.002), pulmonary capillary wedge pressure (PCWP,P=0.006), and inferior vena cava size during inspiration (P=0.005) and expiration (P=0.003). The RAP had the highest AUC for predicting a positive HJR on admission (AUC: 0.655,P=0.004) and discharge (AUC: 0.672,P=0.001). Cox’s proportional hazards analysis revealed that a positive HJR on discharge is an independent predictor of 6-month mortality (estimated hazard ratio: 1.689; 95% CI: 1.032–2.764;P=0.037) after adjusting for age, baseline creatinine, baseline hematocrit, baseline NYHA class, chronic obstructive pulmonary disease, and the presence of tricuspid regurgitation.Conclusion. The HJR should be routinely checked in patients admitted with acute HF throughout hospitalization and especially on discharge as it serves as an important prognostic marker for postdischarge outcomes.
Frequency, Risk Factors, and Adverse Fetomaternal Outcomes of Placenta Previa in Northern Tanzania
Authors: Senkoro Elizabeth Eliet , Mwanamsangu Amasha H. , Chuwa Fransisca Seraphin , Msuya Sia Emmanuel , Mnali Oresta Peter , Brown Benjamin G. , Mahande Michael Johnson
Published: February 2017

Background and Objective. Placenta previa (PP) is a potential risk factor for obstetric hemorrhage, which is a major cause of fetomaternal morbidity and mortality in developing countries. This study aimed to determine frequency, risk factors, and adverse fetomaternal outcomes of placenta previa in Northern Tanzania.Methodology. A retrospective cohort study was conducted using maternally-linked data from Kilimanjaro Christian Medical Centre birth registry spanning 2000 to 2015. All women who gave birth to singleton infants were studied. Adjusted odds ratios (ORs) with 95% confidence intervals for risk factors and adverse fetomaternal outcomes associated with PP were estimated in multivariable logistic regression models.Result. A total of 47,686 singleton deliveries were analyzed. Of these, the frequency of PP was 0.6%. Notable significant risk factors for PP included gynecological diseases, alcohol consumption during pregnancy, malpresentation, and gravidity ≥5. Adverse maternal outcomes were postpartum haemorrhage, antepartum haemorrhage, and Caesarean delivery. PP increased odds of fetal Malpresentation and early neonatal death.Conclusion.The prevalence of PP was comparable to that found in past research. Multiple independent risk factors were identified. PP was found to have associations with several adverse fetomaternal outcomes. Early identification of women at risk of PP may help clinicians prevent such complications.
Class-Specific Histone Deacetylase Inhibitors Promote 11-Beta Hydroxysteroid Dehydrogenase Type 2 Expression in JEG-3 Cells
Authors: Togher Katie L. , Kenny Louise C. , O’Keeffe Gerard W.
Published: February 2017

Exposure to maternal cortisol plays a crucial role in fetal organogenesis. However, fetal overexposure to cortisol has been linked to a range of short- and long-term adverse outcomes. Normally, this is prevented by the expression of an enzyme in the placenta called 11-beta hydroxysteroid dehydrogenase type 2 (11β-HSD2) which converts active cortisol to its inactive metabolite cortisone. Placental 11β-HSD2 is known to be reduced in a number of adverse pregnancy complications, possibly through an epigenetic mechanism. As a result, a number of pan-HDAC inhibitors have been examined for their ability to promote 11β-HSD2 expression. However, it is not known if the effects of pan-HDAC inhibition are a general phenomenon or if the effects are dependent upon a specific class of HDACs. Here, we examined the ability of pan- and class-specific HDAC inhibitors to regulate 11β-HSD2 expression in JEG3 cells. We find that pan-, class I, or class IIa HDAC inhibition promoted 11β-HSD2 expression and prevented cortisol or interleukin-1β-induced decrease in its expression. These results demonstrate that targeting a specific class of HDACs can promote 11β-HSD2 expression in JEG3 cells. This adds to the growing body of evidence suggesting that HDACs may be crucial in maintaining normal fetal development.
Production and Properties of Carbon Nanotube/Cellulose Composite Paper
Authors: Maria Kazi Hanium , Mieno Tetsu
Published: February 2017

Multiwalled carbon nanotube/cellulose composite papers have been prepared by mixing the cellulose with MWNT/gelatin solution and drying at room temperature. The CNTs form an interconnected network on the cellulose paper and as a result CNT paper sheet exhibits enhanced electrical properties and thermal stabilities. It is found that both sides of CNT paper sheet have the uniform electrical conductivities. The sheet exhibits strong microwave absorption in the microwave range of 10.5 GHz. The CNT/cellulose paper is as flexible and mechanically tough as the pure cellulose paper. This work provides a novel and simple pathway to make CNT/cellulose sheet as multifunctional biomaterials for electronic, magnetic, semiconducting, and biotechnological applications.
Bioengineered Plants Can Be a Useful Source of Omega-3 Fatty Acids
Authors: Amjad Khan Waleed , Chun-Mei Hu , Khan Nadeem , Iqbal Amjad , Lyu Shan-Wu , Shah Farooq
Published: February 2017

Omega-3 fatty acids have proven to be very essential for human health due to their multiple health benefits. These essential fatty acids (EFAs) need to be uptaken through diet because they are unable to be produced by the human body. These are important for skin and hair growth as well as for proper visual, neural, and reproductive functions of the body. These fatty acids are proven to be extremely vital for normal tissue development during pregnancy and infancy. Omega-3 fatty acids can be obtained mainly from two dietary sources: marine and plant oils. Eicosapentaenoic acid (EPA; C20:5 n-3) and docosahexaenoic acid (DHA; C22:6 n-3) are the primary marine-derived omega-3 fatty acids. Marine fishes are high in omega-3 fatty acids, yet high consumption of those fishes will cause a shortage of fish stocks existing naturally in the oceans. An alternative source to achieve the recommended daily intake of EFAs is the demand of today. In this review article, an attempt has, therefore, been made to discuss the importance of omega-3 fatty acids and the recent developments in order to produce these fatty acids by the genetic modifications of the plants.
Determination of Tributyltin in Seafood Based on Magnetic Molecularly Imprinted Polymers Coupled with High-Performance Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry
Authors: Yang Hua , Zhang Huien , Zhu Xiao Yan , Chen Shi Da , Liu Lijun , Pan Daodong
Published: February 2017

In this study, Fe3O4 was adopted as a carrier for surface molecular imprinting with two-stage polymerization. First, the functional monomer (methacrylic acid, MAA) was modified on the surface of Fe3O4, which was then polymerized with the template molecule (tributyltin, TBT), cross linking agent (ethylene glycol dimethacrylate, EGDMA), and porogen (acetonitrile), hereby successfully preparing Fe3O4@MIPs prone to specifically identify TBT. The physical properties of Fe3O4@MIPs were then characterized, and adsorption and selection capacities were also assessed. Compared with conventional imprinting polymers, this magnetic molecular imprinting polymer (MIP) displayed significantly increased and more specific adsorption. Meanwhile, its pretreatment was simpler and faster due to magnetic separation characteristics. Using magnetic MIPs as adsorbents for enrichment and separation, detection limit, recovery rate, and linear range were 1.0 ng g−1, 79.74–95.72%, and 5 ng g−1~1000 ng g−1, respectively, for a number of seafood samples. High-performance liquid chromatography-inductively coupled plasma mass spectrometry (HPLC-ICP-MS) was used to analyze Tegillarca granosa, mussels, large yellow croaker, and other specimens, with recovery rates of 79.74–95.72% and RSD of 1.3%–4.7%. Overall, this method has a shorter total analysis time, lower detection limit, and wider linear range and can be more effectively applied to determine MAA in seawater and seafood.
Quantitative Thermal Testing Profiles as a Predictor of Treatment Response to Topical Capsaicin in Patients with Localized Neuropathic Pain
Authors: Serrano A. , Torres D. , Veciana M. , Caro C. , Montero J. , Mayoral V.
Published: February 2017

There are no reliable predictors of response to treatment with capsaicin. Given that capsaicin application causes heat sensation, differences in quantitative thermal testing (QTT) profiles may predict treatment response. The aim of this study was to determine whether different QTT profiles could predict treatment outcomes in patients with localized peripheral neuropathic pain (PeLNP). We obtained from medical records QTT results and treatment outcomes of 55 patients treated between 2010 and 2013. Warm sensation threshold (WST) and heat pain threshold (HPT) values were assessed at baseline at the treatment site and in the asymptomatic, contralateral area. Responders were defined as those who achieved a > 30% decrease in pain lasting > 30 days. Two distinct groups were identified based on differences in QTT profiles. Most patients (27/31; 87.1%) with a homogenous profile were nonresponders. By contrast, more than half of the patients (13/24, 54.2%) with a nonhomogenous profile were responders (p=0.0028). A nonhomogenous QTT profile appears to be predictive of response to capsaicin. We hypothesize patients with a partial loss of cutaneous nerve fibers or receptors are more likely to respond. By contrast, when severe nerve damage or normal cutaneous sensations are present, the pain is likely due to central sensitization and thus not responsive to capsaicin. Prospective studies with larger patient samples are needed to confirm this hypothesis.
Resource Leveling Based on Backward Controlling Activity in Line of Balance
Authors: Zhang Lihui , Tang Yaping , Qi Jianxun
Published: February 2017

The line of balance method that provides continuous and uninterrupted use of resources is one of the best methods for repetitive project resource management. This paper develops a resource leveling algorithm based on the backward controlling activity in line of balance. The backward controlling activity is a kind of special activity, and if its duration is prolonged the project duration could be reduced. It brings two advantages to the resource leveling: both the resource allocated on the backward activity and the project duration are reduced. A resource leveling algorithm is presented which permits the number of crews of the backward controlling activity to be reduced until the terminal situation is reached, where the backward controlling activity does not exist or the number of crews cannot be reduced. That adjustment enables the productivity of all activities to be consistent. An illustrative pipeline project demonstrates the improvement in resource leveling. And this study designed a MATLAB program to execute the design algorithm. The proposed model could help practitioners to achieve the goals of both resource leveling and project duration reduction without increasing any resource.