bluuebunny/crossref_metadata_2025 huggingface dataset:
Legal Lens on Hysteroscopy: A Retrospective Review of Medical Malpractice Claims of Hysteroscopic Procedures
Authors: Baez Adriana C. , Marbin Staci , Carugno Jose
Published: January 2025

Background: Given the expansiveness of diagnostic and therapeutic hysteroscopy, promptly recognizing complications and intervening as necessary to prevent adverse outcomes and minimize legal risk is imperative. We aim to describe the litigious trends in hysteroscopic procedures across the United States; Methods: Publicly available lawsuits published on a well-known legal database, Westlaw, were reviewed. The search term “’hysteroscop!’” was used to filter cases for court opinions containing words with this prefix, including “hysteroscopy”, “hysteroscopies”, and “hysteroscopic.” Adverse events, procedural outcomes, post-procedural surgery urgency, and resultant disabilities were extracted for themes; Results: The primary complication resulting in legal action was uterine perforation (52.9%), followed by claimed technical mistakes (23.5%) and damage to surrounding structures (11.8%). The most common outcome was the need for future corrective surgery (70.6%), and a number of cases resulted in permanent brain damage or death (23.6%). Of the patients that required subsequent corrective surgery (n = 12), 91.7% of them required emergent surgery. Patients sought damages most commonly from individual attending providers (41.2%), attending physician and practice groups/hospitals collectively (41.2%), and additional entities, including resident physicians in training and manufacturers. Awards ranged from $322,308 to $9,387,109; Conclusions: Medical malpractice litigation is challenging to patients and providers alike, often leading to financial, emotional, and professional burden. Our evaluation highlights the variability in adverse events from hysteroscopy which prompt litigation, financial burden of lawsuits, and legal risk of individual providers, in an attempt to improve safety of future procedures.
Identification and Expression Analysis of miR166 Gene Family in Response to Salt Stress in Chrysanthemum
Authors: Wang Di , Wang Shuheng , Zhang Dongyang , Meng Yuan , Qian Ying , Feng Siyu , Bai Yun , Zhou Yunwei
Published: January 2025

cgr-miR166 was observed to be significantly enhanced in Chrysanthemum under 200 mM NaCl treatment. Here, ten family members were identified by aligning cgr-miR166 with scaffold sequences from the Chrysanthemum nankingense genome database, naming them from cgr-miR166a to cgr-miR166j, and their precursors could form stable stem-loop structures. The mature regions were observed to be highly conserved, with the 3′ end being more conserved than the 5′ end. miR166s promoters have been found to contain cis-acting elements responsive to diverse stimuli like the phytohormones ABA and IAA. qRT-RCR results demonstrated that the transcriptome sequencing results were reliable and miR166 was present at different levels in the roots, stems, leaves and flowers of Chrysanthemum. Furthermore, the HD-ZipIII transcription factor was validated to be the target gene of Chrysanthemum miR166s by degradome sequencing. Taken together, the cgr-miR166 family exhibited both evolutionary conservation and diversification. The expression level of miR166 was upregulated in root under salt stress, while the expression level of the target gene HD-ZipIII was downregulated. These findings established the foundation for further understanding the mechanism of miR166-HD-ZipIII modules in salt response and tolerance.
Characterizing Engagement with Web-Based Screening, Brief Intervention, and Referral to Treatment (SBIRT) for Traumatic Stress and Substance Misuse After Interpersonal Violence
Authors: Brockdorf Alexandra N. , Tilstra-Ferrell Emily L. , Danielson Carla K. , Moreland Angela D. , Rheingold Alyssa A. , Salim Selime R. , Gilmore Amanda K. , Siciliano Rachel E. , Smith Daniel W. , Hahn Christine K.
Published: January 2025

Screening, brief intervention, and referral to treatment (SBIRT) is a widely used public health approach for delivering early intervention for substance misuse. SBIRT adaptations that incorporate content on interpersonal violence and posttraumatic stress disorder (PTSD) symptoms may be warranted, as experiences of interpersonal violence are prevalent and associated with greater substance misuse; however, more research is needed to refine the delivery of PTSD-substance use content within the SBIRT model. This study examined clinical data collected as part of a web-based SBIRT developed for co-occurring substance misuse and PTSD symptoms after interpersonal violence to characterize the clinical symptoms and responses of adults presenting to agencies serving intimate partner and sexual violence survivors. The respondents (N = 52) completed self-report measures during the SBIRT tool to personalize the recommendations, as well as motivational enhancement exercises. Descriptive statistics were conducted. The results underscored high rates of probable PTSD, substance use, and trauma-related motives for substance use. The respondents were ready to change their substance use on average after receiving personalized feedback. Many expressed values related to trauma recovery and self-empowerment, perceived these values as useful for substance use reduction, and set goals to seek mental health services or reduce their drinking quantity. The findings point to several clinical targets for integrated PTSD-substance misuse interventions for interpersonal violence survivors.
CDK6-Dependent, CDK4-Independent Synovial Hyperplasia in Arthritic Mice and Tumor Necrosis Factor-α-Induced Proliferation of Synovial Fibroblasts
Authors: Komatsu Rie , Fujii Ryoji , Ogasawara Toru , Suzuki-Takahashi Yuki , Chen Sandy , Sugishita Yodo , Niki Hisateru , Yudoh Kazuo
Published: January 2025

Palbociclib, a dual CDK4/6 kinase inhibitor used for breast cancer, has been explored as a treatment option for rheumatoid arthritis (RA). Preclinical studies have reported palbociclib-induced myelosuppression, but no such effects have been observed in Cdk4 or Cdk6 single-deficient mice. Synoviocyte proliferation-associated in collagen-induced arthritis 1/serum amyloid A-like 1 (SPACIA1/SAAL1) is involved in G1 phase progression. Given that SPACIA1/SAAL1 upregulates CDK6 (but not CDK4) expression, we aimed to determine whether suppressing CDK6 expression alone could prevent synovial hyperplasia without myelosuppression. The effects of CDK6 expression on TNF-α-induced rheumatoid arthritis synovial fibroblast (RASF) proliferation and synovial hyperplasia in collagen-induced arthritis (CIA) mice were investigated by modulating the transcriptional level with a CDK6 expression inhibitor (indole-3-carbinol), CDK6 small interfering RNA (siRNA), and Cdk6-deficient mice. Indole-3-carbinol or CDK6 siRNA inhibited TNF-α-induced RASF proliferation without suppressing CDK4 expression and reduced retinoblastoma protein phosphorylation. In CIA mice, indole-3-carbinol did not cause myelosuppression, considerably delayed CIA onset and progression, and reduced arthritis severity. Cdk6-deficient mice showed similar improvements in CIA pathogenesis but had lower serum anti-type II collagen IgG levels. Notably, synovial hyperplasia was not observed in Cdk6-deficient mice. CIA-synovial hyperplasia depends on CDK6, but not CDK4, expression.
Cornus mas L. Extracts Exhibit Neuroprotective Properties, Further Enhanced by Metal-Bound Energy-Linked Organic Substrates
Authors: Lazopoulos Georgios , Matsia Sevasti , Maroulis Marios , Salifoglou Athanasios
Published: January 2025

Neurodegenerative diseases have been increasingly plaguing the global population, with attempts to understand their etiopathogenesis and pursue therapeutics being at the forefront of multidisciplinary efforts. To that end, research was launched in our lab, based on natural products and bioessential metal ion complex forms to peruse their antioxidant and neuroprotective potential at the cellular level. To that end, the bioactivity profile of optimized Cornus mas L. extracts and supplemented mixtures thereof with soluble-bioavailable well-characterized hybrid materials, Zn(II)-Cit and V(IV)-Cit, was investigated. In vitro experiments on sensitive brain tissue cell lines (N2a58, SH-SY5Y) showed that the extracts and the metal complexes were atoxic (morphology, proliferation, chemotacticity) in a concentration-dependent manner. Subsequently, the antioxidant potential of all materials was examined, with H2O2 as the oxidizing agent, thereby revealing through viability and reactive oxygen species (ROS) visualization significant antioxidant activity, while specific genes (NFE2L2, Hmox1, GCLM) were crucial in divulging mechanistic aspects of the antioxidation. Concurrently, the anti-inflammatory activity was evaluated through gene expression (TNF-a, IL-6), with Zn(II) bioavailability projecting intracellular levels linked to the observed sustainable activity. The collective bioactivity profile of the extracts and Zn(II)-Cit reveals significant neuroprotective properties, thereby meriting development of new naturally-based neutraceuticals that proactively avert neuropathological aberrations.
Emergence and Cytogenetic Clonal Evolution of Chromosome 7 Abnormalities in Myeloid Malignancies: Investigating the Role of Telomere Dysfunction
Authors: Baldazzi Carmen , Bandini Lorenza , Robustelli Valentina , Patuelli Agnese , Venturi Claudia , Grassi Alessandra , Marzocchi Giulia , Ielpo Angela , Solli Vincenza , Bochicchio Maria Teresa , Paolini Stefania , Sartor Chiara , Zingarelli Federico , Curti Antonio , Ottaviani Emanuela , Testoni Nicoletta
Published: January 2025

Monosomy 7 and deletion 7q are common chromosomal abnormalities in myeloid malignancies, and they are associated with a poor prognosis. The mechanism underlying their acquisition remains elusive. We identified a cohort of 24 patients exhibiting clones with different chromosome 7 abnormalities, such as deletion 7q, unstable derivatives (ring chromosomes or ‘naked’ centromeres), and monosomy 7. We designated this group as having cytogenetic clonal evolution of chromosome 7 abnormalities (CCE7). In some cases, CCE7 correlated with disease progression, suggesting that deletions or other derivatives involving the q-arm of chromosome 7 may arise early in the disease course. These abnormalities may be transient but can potentially evolve into monosomy 7. Within the CCE7 group, telomere loss or shortening may contribute to chromosomal instability and the emergence of unstable derivatives, as the chromosome 7 derivatives displayed loss or rearrangement of subtelomeric regions. Moreover, we identified variants in genes implicated in telomere biology disorders and observed specific genetic mutation profiles associated with different chromosome 7 abnormalities. These findings shed light on a potential mechanism leading to monosomy 7 through the evolution of chromosome 7q abnormalities. Identifying patients at risk of developing monosomy 7, based on the presence of unstable derivatives with telomere loss or a specific mutation profile, could potentially enhance patient management and guide the development of novel therapeutic strategies.
Comparison of Recombination Rate, Reference Bias, and Unique Pangenomic Haplotypes in Cannabis sativa Using Seven De Novo Genome Assemblies
Authors: Stack George M. , Quade Michael A. , Wilkerson Dustin G. , Monserrate Luis A. , Bentz Philip C. , Carey Sarah B. , Grimwood Jane , Toth Jacob A. , Crawford Seth , Harkess Alex , Smart Lawrence B.
Published: January 2025

Genomic characterization of Cannabis sativa has accelerated rapidly in the last decade as sequencing costs have decreased and public and private interest in the species has increased. Here, we present seven new chromosome-level haplotype-phased genomes of C. sativa. All of these genotypes were alive at the time of publication, and several have numerous years of associated phenotype data. We performed a k-mer-based pangenome analysis to contextualize these assemblies within over 200 existing assemblies. This allowed us to identify unique haplotypes and genomic diversity among Cannabis sativa genotypes. We leveraged linkage maps constructed from F2 progeny of two of the assembled genotypes to characterize the recombination rate across the genome showing strong periphery-biased recombination. Lastly, we re-aligned a bulk segregant analysis dataset for the major-effect flowering locus Early1 to several of the new assemblies to evaluate the impact of reference bias on the mapping results and narrow the locus to a smaller region of the chromosome. These new assemblies, combined with the continued propagation of the genotypes, will contribute to the growing body of genomic resources for C. sativa to accelerate future research efforts.
Understanding microRNA-Mediated Chemoresistance in Colorectal Cancer Treatment
Authors: Valenzuela Guillermo , Contreras Héctor R. , Marcelain Katherine , Burotto Mauricio , González-Montero Jaime
Published: January 2025

Colorectal cancer (CRC) remains the second most lethal cancer worldwide, with incidence rates expected to rise substantially by 2040. Although biomarker-driven therapies have improved treatment, responses to standard chemotherapeutics, such as 5-fluorouracil (5-FU), oxaliplatin, and irinotecan, vary considerably. This clinical heterogeneity emphasizes the urgent need for novel biomarkers that can guide therapeutic decisions and overcome chemoresistance. microRNAs (miRNAs) have emerged as key post-transcriptional regulators that critically influence chemotherapy responses. miRNAs orchestrate post-transcriptional gene regulation and modulate diverse pathways linked to chemoresistance. They influence drug transport by regulating ABC transporters and affect metabolic enzymes like thymidylate synthase (TYMS). These activities shape responses to standard CRC chemotherapy agents. Furthermore, miRNAs can regulate the epithelial–mesenchymal transition (EMT). The miR-200 family (e.g., miR-200c and miR-141) can reverse EMT phenotypes, restoring chemosensitivity. Additionally, miRNAs like miR-19a and miR-625-3p show predictive value for chemotherapy outcomes. Despite these promising findings, the clinical translation of miRNA-based biomarkers faces challenges, including methodological inconsistencies and the dynamic nature of miRNA expression, influenced by the tumor microenvironment. This review highlights the critical role of miRNAs in elucidating chemoresistance mechanisms and their promise as biomarkers and therapeutic targets in CRC, paving the way for a new era of precision oncology.
Impaired LPS Signaling in Macrophages Overexpressing the P2X7 C-Terminal Domain or Anti-P2X7 C-Terminal Domain Intrabody
Authors: Sakuma Chisato , Takenouchi Takato , Sato Mitsuru
Published: January 2025

The P2X7 receptor is involved in innate immune responses, with its intracellular C-terminal domain capable of interacting with signaling molecules to regulate immune cell activation; however, the mechanisms underlying the signaling complexes remain unclear. To elucidate the function of the P2X7 C-terminal domain, we established bone marrow-derived macrophage (BMDM) cell lines from transgenic (Tg) mice overexpressing the C-terminal domain of P2X7 or anti-P2X7 C-terminal domain single-chain variable fragment (scFv) intrabody. In contrast to wild-type mouse BMDMs, the Tg BMDMs showed impairment of inflammatory responses induced by lipopolysaccharide (LPS) stimulation, such as NF-κB activation and subsequent TNF-α, IL-1β, and IL-6 expression. Furthermore, P2X7 was specifically associated with myeloid differentiation primary response gene 88 (MyD88) in wild-type BMDMs; its specific interaction was strongly interfered with by overexpression of the P2X7 C-terminal domain or anti-P2X7 C-terminal domain scFv in Tg BMDMs. These observations strongly suggest that P2X7 may have pivotal roles in LPS signaling cascades and could modulate macrophage inflammatory responses through its C-terminal domain.
Effects of Climate Change on the Distribution of Papilio xuthus
Authors: Liu Quanwei , Wang Zhuoyuan , Xu Danping , Peng Yaqin , Wu Junhao , Liu Zhiqian , Li Xiushan , Zhuo Zhihang
Published: January 2025

The Papilio xuthus is a widely distributed species in the genus Papilio of the family Papilionidae, possessing ecological, ornamental, and socio-economic service values. To determine the ecological role of P. xuthus and assess its population distribution under future climate change scenarios, this study utilized the MaxEnt model to predict the geographic distribution of P. xuthus in the future and evaluate its population dynamics. The results indicated that P. xuthus is currently widely distributed in East Asia, with a high suitability area of 1827.83 × 103 km2, primarily in China, Japan, North Korea, and South Korea. Climate change has a significant impact on the geographic distribution of P. xuthus, with its high suitability areas decreasing in the future, particularly within China, where the change is projected to be as high as 46.46% under the SSP126 scenario by the 2050s. The centroid of its high-suitability area is expected to shift northeastward. Key environmental variable analysis revealed that Temperature Seasonality, Mean Temperature of the Wettest Quarter, Precipitation of the Wettest Month, and Precipitation of the Warmest Quarter are critical factors influencing the selection of suitable habitats by P. xuthus. This study assessed the distribution of P. xuthus and provided conservation recommendations, offering a reference for future population control and conservation efforts.
Examining Patient Characteristics in Bladder Cancer Clinical Trials Involving Immunotherapy
Authors: Ikhapoh Izuagie , Atairu Usomine , Reich Amanda Jane , Mantia Charlene M. , Wei Xiao X. , Sekar Rishi , Clinton Timothy N. , Mossanen Matthew
Published: January 2025

Background/Objectives: Comprehending the patient composition of bladder cancer (BC) clinical trials is crucial for effectively designing clinical trials and contextualizing the generated science. In this study, we reviewed publicly available data and explored the demographic information of BC studies administering immune checkpoint inhibitors (ICIs). Methods: Trial eligibility was irrespective of government or private sponsorship, and trial activation dates were limited to between 2013 and 2023. The main inclusion criteria were use of ICIs and trials reporting endpoints that include progression-free survival (PFS), overall survival (OS), disease-free survival (DFS), and event-free survival (EFS). The key exclusion terms were review articles and meta-analysis. Results: We identified a total of 109 clinical trials with an aggregate total of 8936 enrolled patients. Ninety-six percent identified as Caucasian or White European, and 23% identified as female. Further analyses revealed that 65% of the patients were aged 65 years or older. One-third of the trials listed similar comorbidities, such as cardiovascular disease and diabetes, that were exhibited by approximately 30 percent of the patients. Conclusions: Our data suggest that recruitment strategies should be mindful of comorbidities that may interfere with ICI treatments. Additionally, our results are consistent with findings from other reviews that indicate that certain patient groups may be under-represented in BC trials.
Exploring Anti-Inflammatory Treatment as Upstream Therapy in the Management of Atrial Fibrillation
Authors: Zheng Edward , Warchoł Izabela , Mejza Maja , Możdżan Maria , Strzemińska Monika , Bajer Anna , Madura Paulina , Żak Juliusz , Plewka Michał
Published: January 2025

Inflammation has been widely recognized as one of the major pathophysiological drivers of the development of atrial fibrillation (AF), which works in tandem with other risk factors of AF including obesity, diabetes, hypertension, and heart failure (HF). Our current understanding of the role of inflammation in the natural history of AF remains elusive; however, several key players, including the NLRP3 (NLR family pyrin domain containing 3) inflammasome, have been acknowledged to be heavily influential on chronic inflammation in the atrial myocardium, which leads to fibrosis and eventual degradation of its electrical function. Nevertheless, our current methods of pharmacological modalities with reported immunomodulatory properties, including well-established classes of drugs e.g., drugs targeting the renin–angiotensin–aldosterone system (RAAS), statins, and vitamin D, have proven effective in reducing the overall risk of developing AF, the onset of postoperative atrial fibrillation (POAF), and reducing overall mortality among patients with AF. This might bring hope for further progress in developing new treatment modalities targeting cellular checkpoints of the NLRP3 inflammasome pathway, or revisiting other well-known anti-inflammatory drugs e.g., colchicine, vitamin C, nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticosteroids, and antimalarial drugs. In our review, we aim to find relevant upstream anti-inflammatory treatment methods for the management of AF and present the most current real-world evidence of their clinical utility.
Perceived Stress Is Linked to Depression but Not to Clinical Outcomes in Maintenance Hemodialysis Patients
Authors: Bossola Maurizio , Angioletti Laura , Di Giovanni Marta , Mariani Ilaria , Di Stasio Enrico , Balconi Michela
Published: January 2025

Background/Objectives: Over the course of end-stage renal disease, patients undergoing hemodialysis (HD) often face significant psychological distress. Nonetheless, little is known about perceived stress levels and related factors in HD patients. This is a cross-sectional study that explores the prevalence of perceived stress levels and the associated variables in HD patients. Methods: Participants included 223 HD patients recruited in June 2024 in Italy. Perceived stress and depression levels were measured with the Perceived Stress Scale (PSS) and Beck Depression Inventory (BDI-II). We also collected clinical and laboratory variables to evaluate their association with PSS. Results: PSS score was moderate in 70.8% and high in 11.2% of the patients. The BDI score was significantly higher in patients with moderate or high perceived stress than in those with low perceived stress. The correlation between PSS and BDI scores was statistically highly significant, and in multivariate regression analysis, PSS score was independently associated with BDI, but not with age, sex, and serum creatinine. Patients with moderate or high perceived stress more frequently had a BDI ≥ 17. In women, with respect to men, the frequency of high and moderate perceived stress was higher. PSS does not correlate with some clinical characteristics such as functional disability (ADL and IADL scores), and the number of comorbidities (Charlson comorbidity Index). Also, we found that there was no correlation between PSS and post-dialysis fatigue prevalence/characteristics, nor between PSS and time of recovery after dialysis. Conclusions: These findings emphasize the critical need for targeted interventions addressing stress management in HD patients, especially with gender-specific approaches.
Recent Advances in Cardiac Resynchronization Therapy: Current Treatment and Future Direction
Authors: Siddiqui Arsalan , Tasouli-Drakou Vasiliki , Ringor Marc , DiCaro Michael V. , Yee Brianna , Lei KaChon , Tak Tahir
Published: January 2025

Cardiac Resynchronization Therapy (CRT) has been established as a major component of heart failure management, resulting in a significant reduction in patient morbidity and death for patients with increased QRS duration, low left ventricular ejection fraction (LVEF), and high risk of arrhythmias. The ability to synchronize both ventricles, lower heart failure hospitalizations, and optimize clinical outcomes are some of the attractive characteristics of biventricular pacing, or CRT. However, the high rate of CRT non-responders has led to the development of new modalities including leadless CRT pacemakers (CRT-P) and devices focused on conduction system pacing (CSP). This comprehensive review aims to present recent findings from CRT clinical trials and systematic reviews that have been published that will likely guide future directions in patient care.
Optimising Sprint Performance in Rugby: Insights from a Systematic Review of Training Methods
Authors: Sanz-Matesanz Manuel , González-Fernández Francisco Tomás , Blanco-Luengo David , Martínez-Aranda Luis Manuel
Published: January 2025

Background: Sprint performance is crucial in rugby, impacting offensive and defensive actions. Despite increasing research on team sports, specific sprint training guidelines for rugby remain limited. This review evaluates the effectiveness of various training methods to improve sprint performance in semi-professional and professional players. Objectives: To identify and assess the most effective training methodologies for improving rugby sprint performance and provide evidence-based recommendations for coaches. Methods: A systematic review adhering to PRISMA guidelines was conducted across PubMed, Web of Science, and SPORTDiscus, including studies published before November 2024. Eligible studies focused on Rugby Union, Rugby League, or Rugby Sevens players undergoing resistance-based or sprint-specific training for at least four weeks. Exclusion criteria included amateur players, athletes under 16, or interventions using advanced technologies. Methodological quality was assessed using the PEDro scale. Results: Twenty-six studies involving 644 rugby players were analysed. Training programmes ranged from 4 to 18 weeks (average: 8 weeks) and were categorised into resistance training, small-sided games, and sprint-specific methods. Resistance training combined with plyometrics and agility drills achieved the most significant sprint improvements. Small-sided games enhanced sprint performance by simulating game-like scenarios, while resisted sprint training showed notable results for short-distance acceleration but limited maximum speed gains. Conclusions: Rugby sprint performance improves through periodised training protocols incorporating resistance exercises, plyometrics, and sport-specific drills. Coaches should use small-sided games and resisted sprint training to target short-distance acceleration and agility. Further research should examine the long-term effects of these methods and their influence on match performance.
The Preparation and Characterization of Poly(lactic Acid)/Poly(ε-caprolactone) Polymer Blends: The Effect of Bisphenol A Diglycidyl Ether Addition as a Compatibilizer
Authors: Arbelaiz Aitor , Landa Beñat , Peña-Rodriguez Cristina
Published: January 2025

The problems created by conventional polymers after their end use have driven research into new biodegradable polymeric materials. PLA is a compostable polymer obtained from renewable sources, but its main drawbacks are its fragility and slow crystallization kinetics. These drawbacks limit its use in different applications. In order to overcome fragility, in the current study, different compositions of PLA/PCL blends, rich in PLA content and without and with DGEBA, were prepared and characterized by means of different techniques, such as FTIR, DSC, DMA, and the mechanical properties. Some compositions show a certain improvement in the deformation capacity compared to the neat PLA at a low test speed. However, when the test speed increases, no improvement is observed in terms of deformation capacity. By SEM, the morphology of injection-molded specimens was observed. All blends showed a biphasic morphology where the PCL droplets are dispersed within the continuous PLA matrix. In the current study, an attempt has been made to improve the compatibility and adhesion between the phases by incorporating a diglycidyl bisphenol A compound. The results obtained indicate that the epoxy groups seem to react with the end groups of the PLA chain; however, the interactions that it creates with the PCL phase are weak, which is in agreement with the FTIR and DSC results obtained.
Experimental and Simulation Study on Vibration Transmission Characteristics and Vibration Isolation Effect of a New Floating Raft Vibration Isolation System
Authors: Xue Qichao , Wang Yonghui , Wang Chaoying , Hu Quansheng , Zou Guangping , Chen Mingtao , He Chuan
Published: January 2025

To enhance the floating raft vibration isolation system’s effect, a new two-stiffness floating raft vibration isolation experimental was constructed. First, the system’s mathematical model was established. The vibration transfer function was deduced via substructure derivative synthesis and four-end parameter matrix methods, and the structural parameter impacts on it were analyzed. Then, a modal test was conducted, and a finite element model was built. Comparing finite element analysis with test results verified the model’s validity, followed by a study of the support structure’s vibration characteristics. Finally, by measuring acceleration responses at the isolator’s upper and lower ends and using the difference as an evaluation index, the isolator’s vibration isolation effect on land and underwater was investigated, along with its impact on the device’s underwater acoustic radiation. The results demonstrate that the two-stiffness vibration isolator can reduce vibration transmission within a specific frequency range both on land and underwater, guiding practical engineering vibration isolation research.
Economic and Sectoral Convergence in Latin America and the Caribbean: An Analysis of Beta, Sigma, and Gamma Convergence
Authors: Navarro-Chávez César Lenin
Published: January 2025

The purpose of this study is to examine the economic and sectoral convergence of 32 countries in Latin America and the Caribbean (LAC) region from 1980 to 2022. The economic convergence hypothesis suggests that two economies with similar structural characteristics but different per capita income levels can tend to equalize in terms of income level in the long run. Confirming economic convergence has led to the development of various methodologies, among which dynamic and static disparity measures stand out. To achieve the objective of this research, both types of measures were calculated, determining beta and sigma convergence for dynamic disparity and gamma convergence for static disparity. This was accomplished by adopting the methodological approaches proposed by Sala-I-Martin and Marchante, Ortega, and Sánchez. The results show a gradual but steady evolution towards economic and sectoral convergence in LAC region during the 1980–2022 period. However, inequalities and divergences persist, requiring less developed countries to strengthen their institutions, implement sound macroeconomic policies, and diversify their economies. These measures are essential to driving economic growth and fostering more balanced and sustainable development across the region.
Diagnostic for Volatility and Local Influence Analysis for the Vasicek Model
Authors: Galea Manuel , Molina Alonso , Beaudry Isabelle S.
Published: January 2025

The Ornstein–Uhlenbeck process is widely used in modeling biological systems and, in financial engineering, is commonly employed to describe the dynamics of interest rates, currency exchange rates, and asset price volatilities. As in any stochastic model, influential observations, such as outliers, can significantly influence the accuracy of statistical analysis and the conclusions we draw from it. Identifying atypical data is, therefore, an essential step in any statistical analysis. In this work, we explore a set of methods called local influence, which helps us understand how small changes in the data or model can affect an analysis. We focus on deriving local influence methods for models that predict interest or currency exchange rates, specifically the stochastic model called the Vasicek model. We develop and implement local influence diagnostic techniques based on likelihood displacement, assessing the impact of the perturbation of the variance and the response. We also introduce a novel and simple way to test whether the model’s variability stays constant over time based on the Gradient test. The purpose of these methods is to identify potential risks of reaching incorrect conclusions from the model, such as the inaccurate prediction of future interest rates. Finally, we illustrate the methodology using the monthly exchange rate between the US dollar and the Swiss franc over a period exceeding 20 years and assess the performance through a simulation study.
From Landscape Architecture to Nature-Based Solutions: A Strategic Approach to Fine Dust Mitigation in Urban School Forests
Authors: Seok Youngsun , Song Kihwan , Chon Jinhyung , Choi Yun Eui
Published: January 2025

Urban areas face increasing environmental challenges, including fine dust pollution and climate change, which significantly impact public health and urban resilience. To address these issues, this study explores the integration of Nature-based Solutions (NbSs) and landscape architecture processes to develop a systematic approach for enhancing urban environmental outcomes. Through a comprehensive review of prior studies, the strengths and weaknesses of NbSs and landscape architecture processes were analyzed, leading to the development of the Nature-based Landscape Process (NLP), which synthesizes the key principles of both approaches. The Dongmyeong Elementary School Fine Dust Mitigation Forest Project was analyzed as a case study to evaluate the applicability of the NLP. This project, implemented using traditional landscape processes, was critically reviewed to identify areas where NbS principles could enhance ecological, social, and functional outcomes. The findings highlight how the integration of NbS principles into landscape architecture processes can address existing gaps and improve project sustainability and precision. This study provides practical insights into the application of the NLP in urban landscape projects, contributing to the development of strategies that align with long-term sustainability and climate adaptation goals.
The Structure and Functioning of Clauses in Upper Kuskokwim Conversational Discourse
Authors: Kibrik Andrej A.
Published: January 2025

Upper Kuskokwim (Athabaskan, Alaska) is a polysynthetic language with morphologically complex verbs involving pronominal affixes denoting clause arguments. One goal of this paper is to see how clauses in this kind of language are organized and operate in conversational discourse. This study is based on a dataset of transcribed conversations, arranged as sequences of elementary discourse units. The issues explored in this article include the structure of clauses, their functioning in discourse, the composition and expression of clause arguments and other participants, as well as an assessment of more and less typical clauses. I find that clauses are strongly aligned with elementary discourse units; that there is a preference for verb-centered, independent, and one-place clauses; and that lexically expressed arguments are rare. Overall, the clause is a viable notion for the description of Upper Kuskokwim conversational discourse. The specifics of clause structure and clause functioning in Upper Kuskokwim can be explained by a combination of general principles of discourse production and the typological features of the language.
Use of Live Biopreservatives and Bacteriophages to Enhance the Safety of Meat Products
Authors: Rodríguez-Marca Cristina , Domenech-Coca Cristina , Nakamura Miho , Ortega-Olivé Nàdia , Puigbò Pere
Published: January 2025

Critical health considerations for both raw and processed meats include addressing bacterial spoilage and ensuring safety. Nitrites and nitrates are widely used in the meat industry to enhance color and flavor and extend shelf life. However, health concerns linked to their use make reducing nitrites and nitrates in meat production a significant challenge with potential benefits for both the food industry and consumer health. This challenge has been addressed with the use of biopreservatives, i.e., substances extracted from natural sources or produced by fermentation that can enhance food quality and safety. In this article, we assess the use of live biopreservatives (LBs), defined here as microorganisms that produce antimicrobial substances that can be used to preserve and extend the shelf life of food. Moreover, the potential synergistic effects of LBs with bacteriophages and biodegradable food packaging for meat is also explored. This innovative combination offers a comprehensive approach to meat preservation, enhancing both microbial control and sustainability. Overall, the inclusion of LBs extends the shelf life of meat products through bacteriostatic mechanisms, whereas bacteriophages offer direct (lytic) action against pathogens. Enhancing meat preservation and safety with mixed microbe-mediated strategies requires deeper empirical and theoretical insights and further revision of laws and ethical considerations.
Microalgae-Derived Carotenoid Extract and Biomass Reduce Viability, Induce Oxidative Stress, and Modulate the Purinergic System in Two Melanoma Cell Lines
Authors: Chitolina Schetinger Luisa , de Jesus Loren S. B. , Bottari Nathieli B. , Viana Altevir R. , Nauderer Jelson N. , Silveira Marcylene V. , Castro Milagros , Nass Pricila , Caetano Patrícia Acosta , Morsch Vera , Jacob-Lopes Eduardo , Queiroz Zepka Leila , Chitolina Schetinger Maria Rosa
Published: January 2025

Cutaneous melanoma (CM) is an aggressive and metastatic tumor, resulting in high mortality rates. Despite significant advances in therapeutics, the available treatments still require improvements. Thus, purinergic signaling emerged as a potential pathway to cancer therapy due to its involvement in cell communication, proliferation, differentiation, and apoptosis. In addition, due to safety and acceptable clinical tolerability, carotenoids from microalgae have been investigated as adjuvants in anti-melanoma therapy. Then, this work aimed to investigate the in vitro anti-melanogenic effect of carotenoid extract (CA) and total biomass (BM) of the Scenedesmus obliquus microalgae on two cutaneous melanoma cell lines (A375 and B16F10). Cells were cultivated under ideal conditions and treated with 10, 25, 50, and 100 μM of CA or BM for 24 h. The effects of the compounds on viability, oxidant status, and purinergic signaling were verified. The IC50 cell viability results showed that CA and BM decreased B16F10 viability at 24.29 μM and 74.85 μM, respectively and decreased A375 viability at 73.93 μM and 127.80 μM, respectively. Carotenoid treatment for 24 h in B16F10 and A375 cells increased the release of reactive oxygen species compared to the control. In addition, CA and BM isolated or combined with cisplatin chemotherapy (CIS) modulated the purinergic system in B16F10 and A375 cell lines through P2X7, A2AR, CD39, and 5′-nucleotidase. They led to cell apoptosis and immunoregulation by activating A2A receptors and CD73 inhibition. The results disclose that CA and BM from Scenedesmus obliquus exhibit an anti-melanogenic effect, inhibiting melanoma cell growth.
Cu-Related Paramagnetic Centers in Cu- and (Cu,Y)-Doped ZrO2 Nanopowders
Authors: Nosenko Valentyna , Vorona Igor , Trachevsky Volodymyr , Zagorodniy Yuriy , Okulov Sergey , Isaieva Oksana , Yukhymchuk Volodymyr , Kulinich Sergei A. , Borkovska Lyudmyla , Khomenkova Larysa
Published: January 2025

In this work, we studied Cu-doped and (Cu,Y)-codoped ZrO2 nanopowders produced through a coprecipitation approach to identify the nature of Cu-related bulk and surface paramagnetic centers. We conducted EPR, NMR, and Raman scattering studies on Cu- and (Cu,Y)-doped ZrO2 powders calcined at different temperatures. At low calcination temperatures (400 °C) and low Cu loading (0.1–1.0 mol.% of CuO), the EPR signal was found to be attributed to surface-related Cu-H2O complexes. For powders with higher Cu content (up to 8.0 mol.% of CuO), the superparamagnetic signal associated with the formation of copper clusters was observed. At higher calcination temperatures, the destruction of Cu-related surface complexes promotes the incorporation of Cu2+ ions into the bulk of ZrO2 nanocrystals at Zr positions. Co-doping ZrO2 with Cu and Y was observed to facilitate the incorporation of Cu2+ ions into cation sites at lower calcination temperatures when compared with Cu-doped ZrO2.
Special Issue: Innovative Material Design and Nondestructive Testing Applications for Infrastructure Materials
Authors: Chang Honglei , Guo Feng
Published: January 2025

Construction materials play a vital role in the design, construction, and maintenance of transportation infrastructure, significantly impacting its safety, durability, and stability [...]
Mitigation of Fiber Print-Through During Replication of Carbon Fiber-Reinforced Polymer Mirrors
Authors: Fan Yuanpeng , Wei Lei , Pei Jian , Li Lin
Published: January 2025

Aiming at the phenomenon of fiber print-through (FPT) during the curing process of carbon fiber-reinforced polymer (CFRP) mirrors, this paper effectively mitigates FPT by improving the replication technique. This paper simulates and analyzes the causes of FPT generation and then improves the replication technique based on multiple explorations of the replication process. In the improved replication technique, a mold is designed to assist in the curing process of the mirrors and to further suppress the FPT on the surface by applying pressure during the curing process. In addition, the layup method, resin matrix, and curing equipment are also optimized and improved. The surface roughness of the CFRP mirrors before and after the process improvement is measured using an optical surface profilometer, and the roughness parameters such as the arithmetic average deviation, root mean square error, and maximum height are obtained. Measurement results show that the improved replication technique effectively mitigates FPT, the surface of the obtained CFRP mirror is smoother, and the application of pressure during curing can further reduce the roughness of the mirror surface.
A Survey on Solving the Matrix Equation AXB = C with Applications
Authors: Wang Qing-Wen , Xie Lv-Ming , Gao Zi-Han
Published: January 2025

This survey provides a comprehensive overview of the solutions to the matrix equation AXB=C over real numbers, complex numbers, quaternions, dual quaternions, dual split quaternions, and dual generalized commutative quaternions, including various special solutions. Additionally, we summarize the numerical algorithms for these special solutions. This matrix equation plays an important role in solving linear systems and control theory. We specifically explore the application of this matrix equation in color image processing, highlighting its unique value in this field. Taking the dual quaternion matrix equation AXB=C as an example, we design a scheme for simultaneously encrypting and decrypting two color images. The experimental results demonstrate that this scheme is highly feasible.
Complex-Valued Multivariate Neural Network (MNN) Approximation by Parameterized Half-Hyperbolic Tangent Function
Authors: Karateke Seda
Published: January 2025

This paper deals with a family of normalized multivariate neural network (MNN) operators of complex-valued continuous functions for a multivariate context on a box of RN¯, N¯∈N. Moreover, we consider the case of approximation employing iterated MNN operators. In addition, pointwise and uniform convergence results are obtained in Banach spaces thanks to the multivariate versions of trigonometric and hyperbolic-type Taylor formulae on the corresponding feed-forward neural networks (FNNs) based on one or more hidden layers.
Acute Kidney Injury, Renal Replacement Therapy, and Extracorporeal Membrane Oxygenation Treatment During the COVID-19 Pandemic: Single-Center Experience
Authors: Ceresa Fabrizio , Monardo Paolo , Lacquaniti Antonio , Mammana Liborio Francesco , Leonardi Aurora , Patanè Francesco
Published: January 2025

Background and Objectives: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) was described in December 2019 for the first time, and it was responsible for a global pandemic. An alarming number of patients with coronavirus disease 2019 (COVID-19) also developed acute kidney injury (AKI), especially those who required extracorporeal membrane oxygenation (ECMO) therapy for acute respiratory distress syndrome (ARDS). The aim of our retrospective observational study was to assess the prognostic significance of AKI in these patients. This study observed, in COVID-19 patients admitted to an intensive care unit (ICU), AKI stages and the need for renal replacement therapy (RRT), assessing the risk factors and outcomes. Moreover, we evaluated the mortality rate of patients treated by ECMO. Materials and Methods: Between November 2020 and December 2022, among 396 patients admitted to our intensive care unit (ICU) diagnosed with SARS-CoV-2 infection, we selected patients with severe ARDS requiring veno-venous (vv) ECMO support and AKI. Results: The 30-day mortality after ECMO positioning was 85.7%. A Cox regression revealed a significant advantage for RRT with a high cut-off (HCO) hemofilter both for ICU mortality (HR 0.17 [95% CI: 0.031–0.935], p = 0.035) and 15 day-mortality after the start of vv-ECMO (HR 0.13 [95%CI: 0.024–0.741], p= 0.021), whereas the early onset of vasoplegic shock after ECMO implantation indicated a higher risk of death (HR 11.55 [95% CI: 1.117–119.567], p = 0.04) during the ICU stay. Conclusions: COVID-19 induces a high risk of AKI and RRT. In our cohort, hypertension, pre-existing renal disease, and mechanical ventilation represented independent risk factors for AKI. Patients requiring ECMO support had a high mortality rate. The early implementation of RRT reduced the risk of death during the ICU stay.
Placebo-Controlled Trials in the Management of Crohn’s Disease: An Umbrella Review of Meta-Analyses
Authors: Silva Richard , Azevedo José Nunes de , Machado Jorge Pereira , Rodrigues Jorge Magalhães
Published: January 2025

Introduction: Crohn’s disease is a chronic inflammatory bowel disease characterized by abdominal pain, diarrhea, and other symptoms. It can lead to significant complications and impact patients’ quality of life. Therefore, effective management strategies are essential for improving outcomes. Methods: To assess the efficacy of the treatments for Crohn’s disease, this umbrella review systematically addresses systematic reviews and meta-analyses on Crohn’s disease management published between 2013 and 2023. The quality of the included studies was assessed using the National Institutes of Health’s quality assessment tool. Results: Sixteen studies were included, evaluating various interventions for the induction and maintenance of remission. These included biologic agents (anti-TNF agents, anti-IL-12/23p40 antibodies, and integrin receptor antagonists), antimetabolites, and corticosteroids. Conclusions: The findings suggest that biologic agents may be promising options for both the induction and maintenance of remission in Crohn’s disease. Antimetabolites and corticosteroids may be effective in certain cases, but their efficacy and safety profiles require further investigation. The included studies varied in quality and sample size. More research is needed to confirm the findings and establish optimal treatment strategies. Moreover, while biologic agents show promise, the optimal management of Crohn’s disease requires further research. A personalized approach considering patient factors and disease characteristics is crucial for optimizing outcomes.