bluuebunny/crossref_metadata_2025 huggingface dataset:
The Implementation Of Hybrid Contracts For Restructuring Non-Performing Financing In Sharia Banks
Authors: Setiawan Iwan , Nurjaman Muhamad Izazi , Herdiana Nana
Published: October 2022

Restructuring non-performing financing is one of the solutions to save financing performance as one of the largest contributors to Islamic banking revenue. However, in practice it is not easy for Islamic banks to do so, because Islamic banks must consider the precautionary principle which has implications for risks that will occur in the future. In addition, the use of hybrid contracts in the restructuring mechanism for non-performing financing is an integral part in minimizing these risks. This study tries to reveal the application of hybrid contracts in the restructuring of non-performing financing in Islamic banking.This article uses a descriptive literature research method obtained from the results of the analysis of the primary data source, namely the substance of the legislation and the DSN-MUI fatwa. So this research uses a normative juridical approach. This type of research includes qualitative research with data analysis techniques that provide a conclusion in the form of accountable information.The results of this study reveal the fact that the application of hybrid contract contracts in the restructuring of non-performing financing in Islamic banking uses a lot of hybrid types of assembled contracts (al-'uqud al-Mujtami'ah), namely the existence of an association of contracts between tabarru' (qordh) and contracts mu'awadhat (sale and purchase, ijarah, IMBT, mudharabah and musharaka).
A Clinical Pilot Study Showing the Safety and Efficacy of Intramuscular Injection of Atelocollagen for Prevention of Paraspinal Muscle Atrophy after Spine Surgery
Authors: Park Hyun-Jun , Hur Jung-Woo , Hong Jae-Taek , Lee Sang-Hyo , Koo Kang-Bin , Kim Dong-Hoon
Published: October 2022

Objective: The objective of this study was to assess the safety and efficacy of intramuscular injection of atelocollagen for the prevention of paraspinal muscle atrophy after spine surgery. Atelcollagen has been widely used as an intradermal filler to restore soft tissue defect. Many studies demonstrated that atelocollagen provides good therapeutic results by promoting cell proliferation and enhances the healing effect on injured connective tissues such as tendons and fasciae, while causing few complications. Methods: A total of 118 patients who underwent single level of posterior lumbar interbody fusion (PILF) between December 2017 and April 2019 were retrospectively reviewed. In the study group of 60 patients, 3 mL of gel-type 3% atelocollagen solution was prepared and injected into the multifidus muscle during wound closure. Clinical efficacy was evaluated by the improvement of back pain, elevation of a muscle enzyme, and inflammatory markers. Radiologic efficacy was evaluated with a comparison of density and cross-sectional area (CSA) of multifidus and erector spinae muscle in CT images. Results: Visual analogue scale (VAS) scores for back pain was not significantly lower in the study group postoperatively compared with the control group. The reduction of postoperative paraspinal muscle density and CSA was significantly lower in the study group. The serum level of muscle enzyme and inflammatory markers were significantly lower in the study group. No major procedure-related complications were observed during the follow-up period.Conclusion: Intramuscular injection of atelocollagen is safe and feasible for the prevention of paraspinal muscle atrophy after spine surgery. This novel method seems advantageous for accelerating wound healing without causing inflammation.
A metabolism-related gene-based prognostic and immunotherapy model for hepatocellular carcinoma
Authors: Zhao Hai-chao , Liu Zi-ang , Chen Chang-zhou , Liu Lu , Song Huang-qin , Tian Yan-zhang , Zhao Haoliang
Published: October 2022

Metabolism-related genes (MRGs) have been confirmed to play an important role in the occurrence and development of hepatocellular carcinoma (HCC). We obtained 88 differentially expressed MRGs according to ROC analysis. The prognostic risk score was then calculated based on 12 MRGs via LASSO regression, and patients were divided into high- and low-risk group. Furthermore, the survival prognostic value of this model was further confirmed in Kaplan–Meier and ROC analysis. Mutations in 12 MRGs were analyzed using cBioPortal. Further analysis showed that MRGs copy number variations (CNVs) in the model were correlated with immune checkpoints (LSECtin and PD-L1) and immune cells. Furthermore, this predictive model was found to be sensitive to immune infiltration and had good predictive value for the expression of immune checkpoints. In conclusion, an MRGs-based HCC prediction model for HCC was established and its effectiveness was verified.
Seroprevalence of SARS-CoV-2 in patients with rheumatic diseases on disease modifying antirheumatic drugs and /or immunosuppressive medications from India: a multicentric study
Authors: Misra Ramnath , Bhattacharya Debdutta , Ahmed Sakir , Amin Sanjiv , Shobha Vineeta , Ghosh Alakendu , Pandya Sapan C , Parai Debaprasad , Padhan Prasanta , Priyadarshini Subhadra , Mohapatra Ipsa , Patro A Raj Kumar , Mohanty Ambika Prasad , Pati Sanghamitra
Published: October 2022

There is an uncertainty regarding the effect of the SARS-CoV-2 infection on patients with chronic rheumatic diseases who are on immunosuppressive drugs. We did a multicentric cross sectional seroprevalence study were conducted in five different cities of India prior to COVID-19 immunization. Patients with a diagnosis of rheumatic disease and on DMARDs were included. Relatives of the patients, preferably staying in the same household with no known rheumatic diseases served as controls (subjects without disease). Serum IgG antibodies to SARS-CoV-2 Receptor Binding Domain (RBD) of the spike protein and nucleoprotein (NP) was assayed. Eight hundred eighty-nine sera (subjects with disease = 379 and in subjects without disease = 510) were assayed. IgG antibodies to either RBD and/or NP were positive in 135 (36%) subjects with disease as compared to 196 (38%) in subjects without disease. The seroprevalence to RBD and NP varied between different cities but was not significantly different between subjects with and without disease in Mumbai, Ahmedabad, Bengaluru and Bhubaneswar. However, the occurrence of IgG antibodies to RBD was significantly (p < 0.05) lower in subjects with disease (28/65;43%) as compared to subjects without disease (42/65;65%) in Kolkata, where the positivity rate was lower in connective tissue disease group than in inflammatory arthritis group. Overall, patients with rheumatic diseases on DMARDs have IgG antibodies to RBD and NP of SARS-CoV-2 at a comparable level with that of subjects without disease, but the level of antibodies to RBD is lower in patients with connective tissue disease on immunosuppressive drugs in one centre.
Multimodal MEMS vibration energy harvester with cascaded flexible and silicon beams for ultra-low frequency response
Authors: Wang Xiaohong , Feng Haizhao , Bu Ling , Li Zhangshanhao , Xu Sixing , hu bingmeng , Xu Minghao , Jiang Siyao
Published: October 2022

Scavenging energy from ambient vibrations has become a promising energy supply for autonomous microsystems. However, restricted by device size, most MEMS vibration energy harvesters have much higher resonant frequencies than environmental vibrations, which reduces scavenged power and limits applicable scenarios. Herein, we propose a MEMS multimodal vibration energy harvester with specifically cascaded flexible PDMS and zigzag silicon beams to lower the resonant frequency to Hertz level and to broaden the bandwidth simultaneously. A two-stage architecture is designed, in which the primary subsystem consists of suspended PDMS beams characterized by low Young’s modulus, and the secondary system consists of zigzag silicon beams. We also propose the PDMS lift-off process to fabricate the suspended flexible beams, a compatible microfabrication method with high yield and good repeatability. The fabricated MEMS energy harvester can operate at ultra-low resonant frequencies of 3 Hz and 23 Hz, achieving maximum normalized voltage density of 200 V/cm3/g2@ 3 Hz. The reasons for output power degradation in the low frequency range and the potential enhancement strategies are discussed. This work offers new insights for achieving MEMS scale energy harvesting with ultra-low frequency response.
A Study on Transboundary Governance of Marine Plastic Debris—the Case of an Adjacent Waters between China and Taiwan
Authors: Ma Hsiang-Yu , Kao Jui-Chung , KAO RUI HSIN , Chiang Nein-Tsu , Cho Cheng-Chung
Published: October 2022

This study aimed to construct a transboundary marine governance mechanism in the Kinmen-Xiamen Waters through literature review, field survey, in-depth interview, and expert opinion survey. The study finding that monsoons, ocean currents and tides are the main factors affecting the drift of marine debris in the Xiamen Sea area to the beaches of Kinmen. The marine debris mainly included marine plastic debris (MPD), bamboo and wood in Kinmen, and was documented impacting a variety of species, including thehorseshoe crab to marine mammals the IndoPacific dolphin. In addition, the problem of marine micro-plastic pollution is becoming increasingly worrisome, and hazardous to rare creatures in the Xiamen Sea area. The pollution sources of MPD in Xiamen Bay included coastal tourism activities, micro-plastic discharged from sewage treatment plants, plastic waste produced by lost and discarded marine aquaculture and plastic drifting terrestrial waste transported by from the Jiulong River Basin.
Monitoring vegetation changes in the dust center of Southwest Iran
Authors: Dinarvand Mehri , Sarab Sajad Alimahmodi , Arami Seyed Abdolhossein , Haidari Kohzad
Published: October 2022

An area equivalent to 26,000 hectares of the dust center of southwestern Iran, located in Khuzestan province, was stabilized between 2015 to 2021 in the form of a biological stabilization and water distribution program. For biological stabilization, Prosopis juliflora shrubs were used and irrigation was done with tankers or furrows at intervals. The objective of this study was to utilize remote sensing technologies, geographic information systems, and field investigation to determine the vegetation changes in two time periods in seven regions within the South West of Iran, during the years 2016 and 2021 (Before and after planting), to show the impact of the native planted species on the natural environment. As the processed images show, there have been wide fluctuations in vegetation in the study area from 2016 to 2021. The slope of changes was positive in all the investigated points. In the first year of the research, in some areas, no plant species were seen or they were very scattered, but in 2021, plant species such as Salsola jurdanica, Atriplex leucoclada, Aeloropus lagopoides, and Bienertia cycloptera were observed with a high percentage of coverage. Of course, it should be noted that the region has a good seed bank. The results of monitoring vegetation changes in the dust center of Southwest Iran (2016–2021), revealed that the irrigation method of seedling area and precipitation conservation structure has an effective role in species diversity of local vegetation in deserts or restoration of fragile rangelands.
The wider the gap between rich and poor, the higher the flood mortality
Authors: Lindersson Sara , Raffetti Elena , Rusca Maria , Brandimarte Luigia , Mård Johanna , Baldassarre Giuliano Di
Published: October 2022

Economic inequality is rising within many countries globally, and this can significantly influence social vulnerability to natural hazards. Through a global analysis of income inequality and flood disasters in middle- and high-income countries, we show that unequal countries tend to suffer higher flood fatalities. Based on our results, we argue that the increasingly uneven distribution of wealth deserves more attention within international disaster risk research and policy arenas.
A non-transcriptional function of YAP physically interacts with α-tubulin to stabilize the mitotic spindle and midbody structures through gaining the acetyl-α-tubulin in lung cancer cell
Authors: Chow Shu-Er , Hsu Chia-Chi , Yang Cheng-Ta , Meir Yaa-Jyuhn
Published: October 2022

The YES-associated protein (YAP), a member of the Hippo pathway, plays pivotal roles in several developmental processes and acts dual functions as a tumor suppressor and an oncogene. In the present study, we identified the non-transcriptional function of YAP acting as the microtubular scaffold protein to maintain the stability of the mitotic spindle and midbody through physically interacting with α-tubulin during mitotic progression. The interaction of YAP and α-tubulin was evident from the co-immunoprecipitation assays and their co-localization in the microtubular structure of the mitotic spindle and midbody in immunostainings. In YAP depletion, the reduction of ECT2, MKLP-1, and Aurora B is consistent with its function in assembling the microtubule-associated proteins. Further, the concomitantly waning α-tubulin and gaining acetyl-α-tubulin during YAP depletion, which occurred at the post-transcriptional level, suggests that YAP functions in maintaining the stability of the mitotic spindle and midbody for ensuring faithful chromosome segregation during mitotic division. Furthermore, the raised acetyl-α-tubulin in YAP depletion may serve as a lesion-halting mechanism in maintaining the microtubule structure. As the resultant multinuclearity and aneuploidy in YAP depletion, it unravels the tumor suppressor role of the transcription-independent function of YAP.
New Empirical Models for Flood Loss Prediction and Implications for the Coterminous United States
Authors: Pollack Adam , Wing Ian Sue , Pinter Nicholas , Nolte Christoph
Published: October 2022

Flood-loss estimates are needed for floodplain development and mitigation projects, for setting fair insurance rates, and for guiding climate adaptation policy. Currently, flood-loss models, including depth-damage functions (DDFs) widely used in the U.S., lack empirical validation commensurate with the geographic extent and diversity of structures and flood exposure over which these predictions are needed. Using data from 845,776 U.S. National Flood Insurance Program claims, we validate DDFs and create alternative models grounded in empirical data and validation. These alternative models more accurately predict average observed damages for many types of structures and hazard compared to current DDFs which omit important variables and interactions that drive observed losses. We find that a major bottleneck in flood-loss estimation is the development and validation of flood-loss models for both damaged and undamaged homes, a gap FEMA could help close.
Evaluation of the deformity of congenital proximal radioulnar synostosis by using a digital technique
Authors: Yang Chen , Liu Lu , Wei Qi-Pei , Bai Fan , Chen Shan-lin
Published: October 2022

Purpose: To find out the influence factors of the “forearm rotation angle” (FR) which related to the severity of CRUS.
Methods: We established 48 digital three-dimensional forearm bones models of 48 patients with congenital radioulnar synostosis (CRUS) classified as Cleary and Omer type 3. In total, 10 independent deformities involved in the CRUS complex deformity were measured. Pearson correlation analysis for each deformity was performed and multivariate linear regression analysis was also performed with FR as the dependent variable and the other deformities as the influential factors.
Results: The “dorsal angle of radius” (DAR) had the strongest correlation with the FR (0.601, P<0.01), the internal rotation angle of the radius (IRAR) has a moderate correlation with FR (0.552, P<0.01). A forearm deformity equation was established: FR=35.896+0.271 DAR+0.989 IRAR.
Conclusion: The results of this study and the forearm deformity equation may be significant in guiding clinical practice.
Level of Evidence: Level 4 Evidence.
Hypoxia-elicited exosomes promote the chemoresistance of pancreatic cancer cells by transferring lncROR via Hippo signaling
Authors: Wang Huizhi , Min Jingyu , Liu Junqiang , Xu Chunhui , Liu Yawen , Yu Zhengyue , Gong Aihua , Xu Min
Published: October 2022

Recent studies have found that hypoxia contributes to tumor progression and drug resistance via inducing exosomes secretion. However, the underlying mechanism of this resistance in pancreatic cancer remains to be explored. In this study, we explored the effect and molecular mechanisms of hypoxia-induced tumor-derived exosomes (Hexo) on stemness and gemcitabine (GEM) resistance in pancreatic cancer cells. Firstly, we discovered that hypoxia could promote the stemness and induce gemcitabine resistance in pancreatic cancer cells. Subsequently, we proved that exosomes secreted by pancreatic cancer cells under normoxic or hypoxic conditions can be transfected into tumor cells. And then, Hexo was demonstrated to promote the proliferation, stemness and Gem resistance of pancreatic cancer cells, as well as inhibit the apoptosis and the cell cycle arrest induced by gemcitabine. Finally, it was verified that Hexo could inactivate the Hippo/YAP pathway of pancreatic cancer cells by transferring exosomal lncROR. In summary, hypoxic tumor microenvironment could promote the stemness and induce gemcitabine resistance in pancreatic cancer cells. Mechanically, Hexo enhanced the stemness to promote chemoresistance of pancreatic cancer cells by transferring lncROR via Hippo signaling. Thus, exosomal lncROR may serve as a candidate target for pancreatic cancer chemotherapy.
Gentrification and Air Quality in a Large Urban County in the United States
Authors: Hutchings Hollis Elizabeth , Zhang Qiong , Grady Sue , Mabe Lainie , Okereke Ikenna C
Published: October 2022

Objectives: To determine the association of gentrification with changes in racial distribution and in air quality in each zip code of a large urban county over a 40 year period.
Design: This was a retrospective study over 40 years in a large urban county, using sociodemographic data and air quality data from the NHGIS and US EPA respectively. To assess gentrification, longitudinal analyses were performed to examine median household income, percent with a college education, median housing value, median gross rent and employment level. Racial distribution was evaluated in each zip code during the time period.
Results: Gentrification was associated with worsening of air quality and strongly associated with racial distribution. The most substantial gentrification occurred from 2010 to 2020, in which a specific cluster of adjacent zip codes in Detroit experienced intense gentrification and drop in percentage of African American residents.
Conclusions: Gentrification is associated with worsening pollution and air quality and associated with an increase in non-minority residents. This increased pollution is likely secondary to increases in traffic density and creation of buildings with increased emissions. Displaced residents do not get to experience the improvements in housing quality, accessibility to healthy foods and other benefits of gentrification.
Pembrolizumab combined with Axitinib in ASPSCR1-TFE3 gene fusion translocation renal cell carcinoma: a case report and literature review
Authors: Bai Yinmiao , Wang Xiaowen , Liu Yang , Ji Hongchen , Liu Zhihui , Sun Juanhua , Zhang Hong-Mei
Published: October 2022

Background: Translocation renal cell carcinoma (tRCC) is a subtype of nccRCC driven by MiT/TFE gene fusion. The demographic characteristics of tRCC include younger age at diagnosis, later staging at diagnosis, high degree of malignancy, poor prognosis, and female majority. There are currently no standard guidelines for the diagnosis and treatment of this type of kidney cancer. Objective: To investigate the efficacy of immuncheckpoint blockadeinhibitor combined with anti-VEGF receptor tyrosine-kinase inhibitors in ASPSCR1-TFE3 gene fusion translocation renal cell carcinoma(tRCC).
Case presentation: The paper describes a case of a 42-year-old Chinese female presented enlargement of multiple lymph nodes. Percutaneous aspiration cytology of the tumor on the left side of neck lymph node was confirmed to be malignant. Combined with pathology, PET-CT and genetic testing, the patient was diagnosed with ASPSCR1-TFE3 gene fusion tRCC with multiple metastases (left kidney, cT1aN1M1, stage IV), involving lymph nodes,liver, and bone. The patient was treated with Pembrolizumab combined with Axitinib. Up to June 2022, the patient's progression-free survival time was was more than 2 years, lesions in left kidney, lymph nodes, liver and bone reached stable status, partial response, complete response and stable status, respectively. The patient can receive treatment for side effects.
Conclusions: The report of this case could provide a helpful strategy for combination therapy of PD-1 antibody and VEGFRs inhibitor in rare ASPSCR1-TFE3 gene fusion tRCC.
Genomic Evolution of Sars-Cov-2 in Molnupiravir-Treated Patients Compared to Paxlovid-Treated and Drug-Naïve Patients: A Proof-of-Concept Study
Authors: Alteri Claudia , Fox Valeria , Scutari Rossana , Burastero Giulia Jole , Volpi Sara , Faltoni Matteo , Fini Vanessa , Granaglia Annarita , Esperti Sara , Gallerani Altea , Costabile Valentino , Fontana Beatrice , Franceschini Erica , Meschiari Marianna , Campana Andrea , Bernardi Stefania , Villani Alberto , Bernaschi Paola , Russo Cristina , Guaraldi Giovanni , Mussini Cristina , Perno Carlo
Published: October 2022

Molnupiravir and Paxlovid are the only antivirals approved for COVID-19 treatment. Previous studies have evaluated their efficacy, tolerability, and viral clearance, but little is known about SARS-CoV-2 evolution under their pressure. Here the dynamics of genomic evolution of SARS-CoV-2 in 8 Molnupiravir-treated, 7 Paxlovid-treated and 5 drug-naïve individuals at 4 time-points (Day 0, Day 2, Day 5 of treatment and Day 7) were in-depth investigated. SARS-CoV-2 strains under Molnupiravir pressure were characterized by a higher genetic diversity compared to Paxlovid and no-drug pressure (mean ± SE: 18.66x10− 4±2.06x10− 4 vs. 3.34x10− 4±0.84x10− 4 vs. 3.10x10− 4±0.84x10− 4, P = 0.0003), with a peak between Day 2 and Day 5. Molnupiravir drove the emergence of more G-A and C-T transitions than other mutations (P = 0.031), regardless of SARS-CoV-2 genes. SARS-CoV-2 under Molnupiravir pressure did not show selective evolution different than that under Paxlovid or no-drug pressure, with the only exception of orf8 (dN > dS, P = 0.001); few amino acid mutations were enriched consistently at specific sites. No evidence of RdRp or Mpro mutations conferring resistance to Molnupiravir or Paxlovid was found. This proof-of-concept study defines the SARS-CoV-2 within-host evolution during antiviral treatment, confirming the higher in vivo variability induced by Molnupiravir respect to Paxlovid and controls, albeit not resulting in selection of resistance mutations.
Synthesis and cytotoxic/antimicrobial screening of 3-alkenylimidazo[1,2-a]pyrimidines
Authors: Ramírez-Trinidad Angel , Carrillo-Jaimes Karol , Rivera-Chávez José A. , Hernandez-Vazquez Eduardo
Published: October 2022

Polyaza-heterocycles show a plethora of biological properties and represent a significant percentage of clinically used drugs. However, the imizado[1,2-a]pyrimidine ring system needs more attention in terms of pharmaceutical applications. Herein, we report a sequence involving an aldolic condensation/bromination/Hantzsch reaction to construct a series of 3-alkenylimidazo[1,2-a]pyrimidines for exploring their cytotoxic and antimicrobial properties. After performing a preliminary screening, two compounds displayed good cytotoxicity against prostate, breast, and colon cancer types; bulky and an extra phenyl attached at the styryl moiety seem to be a requirement for good activity. With respect to the antimicrobial effect, some compounds showed considerable inhibition against multi-drug resistant K. pneumoniae, one of the most threating bacteria nowadays. Thus, the series may become the basis for the design of more active compounds.
A Distributed Static Time-varying Feedback for Formation Tracking Control of 2nd-order Nonholonomic Systems with Cooperative-Competitive Interactions
Authors: Xie Wenjing
Published: October 2022

Formation tracking task is generally achieved by designing dynamic controllers, which yield additional inertial effects and may increase the difficulty of algorithm implementation. This paper presents a new static feedback to solve the formation tracking control problem of 2nd-order nonholonomic systems with cooperative-competitive interactions. Firstly, a time-varying position output is constructed to obtain double-integrator dynamics. Compared with the traditional hand position output, the constructed output makes it possible to achieve both small control inputs and small ultimate bound, and hence renders the resulting feedback more beneficial to practical applications. Then, the feedback is designed as the proportional derivative type with a correcting term, which overcomes the difficulty of controlling higher relative-degree system, and removes the dependence of control coefficients on spectral feature of interaction network. Rather than using external variables, the static feedback involves the special correcting term to eliminate the residual error caused by dynamic leader who is unavailable to some systems. Global uniform ultimate boundedness of the closed-loop double-integrators is strictly proved by applying Lyapunov method, graph theory and cascaded system theory. After this, a technical lemma about nonlinear system is developed to clarify the convergence of orientation and angular velocity under some persistently exciting condition on leader. Finally, simulations for six 2nd-order nonholonomic systems are carried out to demonstrate the formation tracking performance of the proposed static feedback controller.
A direct nonlinear humidity and temperature tracking controller for an air-handling unit based on backstepping scheme
Authors: Sun Yulong , Liu Cungen , Li Xiangbao , Peng Wei , Liu Xiaotong
Published: October 2022

Aim at an air-handling unit (AHU), this article describes a direct design scheme for humidity and temperature tracking control. The nonlinear dynamic model of the AHU is treated directly by backstepping strategy, which can reserve the modeling qualifications and make better use of known information than proportion integration differentiation (PID) and other non-model-based schemes. Simultaneously, the linearization technique is not adopted, so that the model structure is not changed, which can retain the original system model restrictions to variables and does not lose useful conditions about the system model. These two points ensure the developed controller to achieve higher accuracy and better tracking performance, which is verified by stability analysis and comparisons of simulation results.
Number of psychotropic medications on admission and fall or injury diagnoses in older adults admitted to a large urban hospital from 2016-2021: opportunities for deprescribing
Authors: Keller Michelle Sophie
Published: October 2022

To prepare for an intervention aimed at increasing inpatient/post-discharge counseling about the risks of and deprescribing potentially inappropriate psychotropic medications, we examined sedative use on admission in a large urban hospital over a 5-year period and focused on older adults admitted for a fall or injury diagnosis.
Clinical Manifestations and Progression of Varicella among Adults at Siriraj Hospital, Thailand: A Prospective Cohort Study
Authors: Jiamton Sukhum , Chanyachailert Pattriya , Phumariyapong Phumithep , Nanchaipruek Yanisorn
Published: October 2022

Varicella is a highly contagious viral disease that is very common in children. Adults are less likely to acquire varicella; however, therate of its complication is higher. There are few published data on varicella among adults in Thailand. This study aimed to demonstrate the clinical manifestations, progression and environmental factors of varicella in adults.
From January 2018 to June 2022, a prospective cohort study was conducted among adult patients diagnosed with varicella visiting Siriraj Hospital. Demographic data, history of varicella and varicella vaccination, onset, types of lesions, and distribution were recorded. Participants were followed until the varicella was completely cured. During the study, the average temperature of each month was recorded.
Fifty patients were included inthe study. Interestingly, varicella was diagnosedin patients with a history of varicella infection (18%) or varicella vaccination (14%), especially in healthcare providers. Generalized vesicles were the most common manifestation. From the univariate or multivariate analysis, the duration of the curewas shown to be significantly shorter among those who had a history of vaccination by approximately 3 days (p=0.007). The duration of cure was not significantly associated with age, sex, receiving treatment within 48 hours after the initial lesions, or having a history of previousvaricella. Interestingly, the number of varicella patients per month was found to be significantly lower in months with an average temperature greaterthan 30 degrees Celsius (p<0.0001).
Our findings demonstrated that varicella reinfection occurs in Thai adults and in those with a history of vaccination. Adults who had been vaccinated had a significantly shorter duration of the disease. Therefore, varicella vaccination is recommended, particularly among healthcare professionals who may have contact with varicella patients.
Effect of irrigation scheduling and residue management tillage on soil water balance and growth of wheat
Authors: Singh Malkit , Singh Kanwar Barjinder , Brar Satinder Singh , Singh Baljit
Published: October 2022

The present study was conducted in wheat at the Punjab Agricultural University Seed Farm, Ladhowal, Ludhiana, to study effect of three irrigation regimes ( based on IW/PAN-E ratio of 0.6 (I1), 0.8 (I2) and 1.0 (I3) in main plots and four tillage practices (mould board ploughing to a depth of 25 cm followed by rotavator (PT25 + R), mould board ploughing to a depth of 14 cm followed by rotavator (PT14 + R), zero tillage with happy seeder (ZT) and conventional tillage with 2 discing + 2 cultivator followed by planking (CT) in sub plots) on soil water balance and crop growth for two consecutive years (2016-17 and 2017-18). Irrigation scheduling and tillage practices has no significant effect on plant germination and thousand grain weight. However overall mean plant height, leaf area index, root length density and root mass density were significantly higher in I3 over I1 and I2 by 2.1 & 2.8%, 16.82 & 7.75%, 2.04 & 5.22% and 5.82 & 8.73% respectively. During both the years straw and grain yield were significantly higher in I3 over I1 and I2. Significantly higher water productivity was observed in I2 over I1 and I3 by 27.38 & 2.26% in 2016-17 and 27.70 & 1.91% in 2017-18. During 2016-17 maximum water depletion was in I1 over I2 and I3 by 2.15 &4.86% and 4.5 & 7.52 in 2017-18. Over PT14 + R, ZT and CT, the tillage practice of PT25 + R significantly increased number of tillers by 5.13,19.42 & 11.82%, plant height by 3.44, 8.38 & 10.37%, leaf area index by 13.45, 26.17 & 27.36%, root length density by 19.30, 61.81 & 46.17% and root mass density by 35.90, 317.67 & 48.16% respectively. During both years significantly higher straw and grain yield were observed in PT25 + R over PT14 + R, ZT and CT. During both years significantly higher soil moisture storage was observed in I3 and ZT compared to other irrigation and tillage practices. Water balance component E&T were higher in PT25 + R than ZT.
Plexiform schwannomas of the sciatic nerve: a case report and review of the literature
Authors: Yan Jiabao , Zhou Ruijun , Liu Bingxin , Cao Xuewei
Published: October 2022

Background: Plexiform sciatic schwannoma is a rare tumor.Schwannoma is deceptive when it appears on the sciatic nerve. We report a rare case of plexiform sciatic schwannoma that was initially diagnosed as a lumbar disease.
Case Presentation: A 43-year-old female complained of pain in her low back and left thigh for 10 years.Physical examination and MRI confirmed that she had a rare plexiform sciatic schwannoma.After obtaining the patient's consent, we performed intracapsular excision of her tumor.The patient recovered well after operation and there was no sign of nerve injury.
Conclusions: Schwannomas in the sciatic nerve are misleading and doctors should pay attention to physical examination and MRI.Intracapsular excision is the best treatment for schwannomas.
Machine Learning Approach for Detecting and Combating Bring Your Own Device (BYOD) Security Threats and Attacks: A systematic Mapping Review
Authors: Eke Christopher Ifeanyi , Norman Azah Anir , Mulenga Mwenge
Published: October 2022

Bring your own device (BYOD) paradigm that permits employees to come with their own mobile devices to join the organizational network is rapidly changing the organizational operation method by enhancing flexibility, productivity, and efficiency. Despite these benefits, security issues remain a concern in organizational settings. A considerable number of studies have been conducted and published in this domain without a detailed review of the security solution mechanisms. Moreover, some reviews conducted focused more on the conventional approaches such as mobile content management, and application content management. Hence, the implementation of security in BYOD using the conventional method is ineffective. Thus, machine learning approaches seem to be the promising approach, which provides a solution to the security problem in the BYOD environment. This study presents a comprehensive systematic mapping review that focused on the application of the machine learning approach for the mitigation of security threats and attacks in the BYOD environment by highlighting the current trends in the existing studies. Five academic databases were searched and a total of 753 of the primary studies published between 2012 and 2021 were initially retrieved. These studies were screened based on their title, abstract and full text to check their eligibility and relevance for the study. However, forty primary studies were included and analyzed in the systematic mapping review (SMR). Based on the analysis and bubble plot mapping, significant research trends were identified on security threats and attacks, machine learning approaches, datasets usage, and evaluation metrics. The SMR result demonstrates the rise in the number of investigations regarding malware and unauthorized access to existing security threats and attacks. The SMR study indicates that supervised learning approaches such as SVM, DT, and RF are the most employed learning model by the previous research. Thus, there is an open research issue in the application of unsupervised learning approaches such as clustering and deep learning approaches. Therefore, the SMR has set the pace for creating new ground research in the machine learning implementation in the BYOD environment, which will offer invaluable insight into the study field, and researchers can employ it to find a research gap in the research domain.
Important factors to consider when choosing a sun protection product
Authors: Couteau Céline , Brenaut Emilie , Misery Laurent , Coiffard Laurence
Published: October 2022

Sun protection products serve as part of a strategy to prevent photoinduced skin cancers. The products currently on the market vary considerably, both in terms of their galenic formulation and their composition. Some are formulated using organic UV filters, some using mineral UV filters, and some using a mixture of both types. In this context, healthcare professionals, particularly dermatologists and pharmacists, are faced with selecting the product best suited to the patient/user, especially during summer. Our aim here is to establish a decision tree to enable an informed choice.
Diagnosis of autism spectrum disorder based on functional brain networks and machine learning
Authors: Alves Caroline , Toutain Thaise G. L. de O. , Aguiar Patricia de Carvalho , Pineda Aruane M. , Roster Kirstin , Thielemann Christiane , Porto  , Rodrigues Francisco A.
Published: October 2022

Autism spectrum disorder is a multifactorial neurodevelopmental disorder with high genetic heterogeneity. Studies of brain networks in autism can provide new insights into the dynamics of information processing in individuals who suffer from such a condition. This paper proposes a method for automatic diagnosis of autism based on fMRI time series and machine learning algorithms. We verify that the left ventral posterior cingulate cortex region reduces the functional connectivity of the brain area in patients with autism spectrum disorder. Also, the brain networks of patients with autism spectrum disorder show more segregation, lower distribution of information, and less connectivity. Our methodology accurately differentiates control and autistic subjects providing an area under the curve close to higher than 95%.
Seismic resurfacing of asteroid (433) Eros from cratering impact suggests presence of asteroid families in near-Earth space
Authors: Ballouz Ronald-Louis , Ernst Carolyn , Barnouin Olivier , Daly Ronald , DellaGiustina Daniella , Hyatt Benjamin , Martin Anna
Published: October 2022

An asteroid’s interior contributes to the response of its surface and shape to forces from space, including meteoroid impacts [e.g., Chapman 1996, Bottke et al. 2020], tidal effects [e.g., Hurford et al. 2016, Binzel et al. 2010], and solar radiation [Walsh et al. 2008]. Changes to asteroid surfaces from these external forces provide a record of the collisional and dynamical evolution of the inner Solar System [Bottke et al. 2020]. However, asteroid interiors remain poorly understood [Asphaug 2020].

(433) Eros is a 34 km x 11 km x 11 km diameter elongated near-Earth asteroid (NEA) with surface expressions that suggest a heavily fractured yet coherent interior, as evidenced by craters formed with structural control [Prockter et al. 2002] and by surface lineaments [Buczkowski et al. 2008], which are common features on 10-km-scale asteroids observed by spacecraft [Veverka et al. 1994, Barucci et al. 2015] that may be surface expressions of widespread interior fractures.

Here we report on measurements of the degradation of the D > 500 m crater population in the vicinity of the 7.5-km-diameter Shoemaker crater, indicating that seismic surface waves and crater ejecta, rather than seismic body waves [Richardson 2005, Thomas & Robinson 2005], erased craters with D < 500 m only up to 10 km away from the crater center. We use crater degradation measurements to estimate a surface wave seismic diffusivity of 0.02 km2/s for Eros regolith.

We determine from these observations that 10-100-km scale fractured asteroids strongly attenuate impact-induced seismic surface waves and seismic resurfacing is limited to local regions, less that 3 crater radii from the impact point.

Our results indicate that Shoemaker crater formed 6.5–31.8 Ma, while Eros was in a main-belt resonance zone. The age of Shoemaker crater coincides with the cosmic ray exposure age of some ordinary chondrites and the returned samples from the 0.3-km-diameter, S-type NEA Itokawa [Nagao et al. 2011]. The concurrence of ages suggests that large cratering impacts on to 10-km scale asteroids are an important source of NEAs and meteorites.
Strategies for Efficient Handling and Economic Circularity for Construction and Demolition Waste in India
Authors: Choudhary Sanjay , Kaur Harshita , Tripathi Bhavna , Chandra Tarush
Published: October 2022

The construction materials industry has been acclaimed as an enormous economy and is expected to continue to rise in future. Over the past few years, India's urban built environment has been expanding rapidly to accommodate the increasing urban population and to meet the rising aspirations of upscaling standards of living. In addition to new projects, redevelopment works are also prominent amongst the construction activities being undertaken all across our urban areas. The large-scale construction and demolition waste (C&D waste) is generated inadvertently from on-going construction activities with no major sustainable interventions or practices in place ever since. The state of art overview of C&D waste management practices and related legislation in India and select countries abroad provides sufficient opportunity for introducing and promoting circular economy (CE) in C&D waste management. This can be done through direct reuse or by recycling/ repair /refurbishment in different stages of construction projects. Reports on key infrastructure projects suggest project delays and cost over-run due to shortage of fresh stocks of primary construction materials. Promoting design of products or components remanufactured using dismantled or recycled C&D waste would no longer let the C&D waste remain as a threat to sustainable environment. Instead, the industry would get geared up to produce high-quality secondary raw materials that can be fed back into production processes. This will not just reduce the reliance on primary resources for construction materials like stone, sand, etc. but also promote the new business models which will focus on waste prevention and ‘turning waste into resources’ by effectively and efficiently utilizing C&D waste in a sustainable manner. This will embed circular economy in the system and also make the process more sustainable. Present models for sustainability assessment are primarily based on statistical records of C&D waste quantities and they rarely include all three aspects of sustainability (economic, environmental and social). This paper proposes a conceptual model of efficient C&D waste management strategies considering all the three aspects of sustainability. A conceptual model has been developed using the barriers and motivating factors obtained from literature review for implementation of effective C&D waste management for circular economy. Using existing knowledge of the components of C&D waste management system and the positive or negative relationships between them the proposed conceptual model focuses on strategies, institutional arrangement and economic circularity for managing the C&D waste. The paper highlights the need for an institutional framework and suitable strategies for efficient handling of C&D Waste. The paper concludes with possible future directions and potential policy recommendations for optimizing C&D waste management in India.
Choosing Nitrogen Application Rate Recommendation Given Florida’s Regulatory Water Policy
Authors: He Fei , Borisova Tatiana , Athearn Kevin , Hochmuth Robert , Barrett Charles
Published: October 2022

State and federal policies in the United States focus on agricultural best management practices (BMP)—such as improving nutrient management—to address water quality issues. BMP development is a challenging process as a new BMP may also affect farm profitability. This article explores the economic feasibility of nitrogen (N) management programs, including nitrogen application rates (N rates), given alternative scenarios for current nitrogen use and producer risk perceptions of carrot production in Florida. In this study, eight alternative N rates are ranked to find the economically optimal BMP. Carrot profitability is determined based on carrot yields per hectare, input costs, and carrot sale prices, using data from a 2-year carrot production experiment. The analysis applied stochastic simulation to account for the uncertain factors by using Simetar Add-In for Excel. We found that 224 kg·ha−1 N fertilizer rate is the most preferred by the producers among the eight rates considered. According to Florida’s agricultural water policy, BMP recommendations should balance water quality improvements and agricultural productivity. We consider the potential reduction of nitrogen fertilizer rate BMP from 224 kg·ha−1 to 168 kg·ha−1 and show that the effect of such reduction depends on producers’ current fertilizer application rates and their risk aversion levels. For example, reducing the N fertilizer rate from 336 kg·ha−1 to 168 kg·ha−1 decreases mean net returns by only 2% ($49/ha). In contrast, reducing the nitrogen fertilizer rate from 224 kg·ha−1 to 168 kg·ha−1 reduces the mean net returns by $151/ha, with an almost 10% reduction in the certainty equivalent of the net returns (for extremely risk-averse producers). Overall, if most producers in the region are very or extremely risk-averse, and if most of them operate close to the optimal level of fertilizer use, then setting the more restrictive BMP of 168 kg·ha−1 N can be perceived as undermining their economic profitability and require significant cost-share incentives to ensure targeted 100% adoption of BMP recommendations.
Research Hotspots and Development Trends of Konjac Based on Bibliometric Analysis
Authors: Shen Chuan , Li Xia
Published: October 2022

Amorphophallus belongs to the family Araceae and contains a high-molecular-weight polysaccharide that was originally extracted from corms called Konjac glucomannan. During the past 10 years, a vast body of research of Amorphophallus konjac has been published. Based on the Web of Science literature database, this work used Co-Occurrence, VOSviewer, and SciMAT bibliometrics analysis software tools to conduct literature analyses and big data mining of Amorphophallus Konjac research from Jan. 2012 to Dec. 2021. Therefore, the present research sorted the development process of this field and analyzed the popular changes in research topics by combing through the visualization of the analysis results to systematically review and forecast the research of Amorphophallus Konjac-related fields. This work discusses current research trends and hotspots and explores and analyzes the content that needs improvement to provide a reference for follow-up research.