bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of Embellishment Techniques to Fashion Products with Pekalongan Buketan Batik Inspiration
Authors: Anjani Sophia Dewi , Sekar Ahda Yunia
Published: January 2025

The fashion business is now experiencing several advancements, including the employment of methods for manufacturing decorations, among others. However, many people in Indonesia have yet to recognize the enormous potential for developing cultural diversity by preserving Indonesian culture by utilizing traditional cloth in a way that adapts the Batik Buketan motif using the Tasik Embroidery technique, which will be combined with beads made into embellishments and applied to fashion products. The local fashion sectors have changed dramatically over time, starting with the processes utilized to create wonderful fashion goods using sustainable principles. Several designers apply embellishment methods, such as designer Biyan Wanaatmadja uses floral patterned embroidery and beading accents; Benita Oktaviana applies a custom-made cheongsam with embroidered elements; Nita Senoadji uses Indonesian traditional literature motifs which he applied in the form of embroidery; and Cynthia Tan adds custom-embroidered lettering on the wedding dress. This research provides an understanding of why designers play such a crucial role in maintaining Indonesian culture. This research employs qualitative methods of investigation. The findings of this study take the shape of an experimental examination of beading mixed with Tasik embroidery techniques, which will result in new decorative innovations in the form of bead embroidery that can be applied to fashion goods created with beading techniques.
Keywords: embellishment, tasik embroidery, sustainable, buketan batik
The Bike Boom: An Indonesian Massive Bike Riding Movement
Authors: Irawan Ahmad Fathan Rizqi , Koesoemadinata Mohammad Isa Pramana
Published: January 2025

The Bike Boom or the massive increase in the use of bicycles in Indonesia by urban communities during the COVID-19 pandemic is unavoidable. Stress and the desire to maintain health during a pandemic, are the triggers that emerge from urban communities to start cycling. These activities must have other factors that can trigger a unison action. This massive cycling activity is not the first time in Indonesia and can be categorized as urban culture. This research aims to understand this phenomenon through online literature studies that discuss the history of cycling itself, especially in Indonesia, the factors that cause this phenomenon to occur in unison and massively in urban communities, and the resulting impacts of that matter. The results showed that celebrities greatly influence this phenomenon, and its impacts are divided into environment, business, and design.
Keywords: bicycle, pandemic, urban
Design Thinking Approach for Better User Experience: A Systematic Review
Authors: Swasty Wirania , Soedewi Sri , Mustikawan Arry
Published: January 2025

Design thinking works well in user experience (UX) design, but there are few empirical studies on it. Thus, a systematic literature review is needed to understand the research topic better and recommend future research. The review followed the PRISMA 2020 Statement. The selected database is Scopus as it covers reputable publications. The search terminology is “design thinking” AND “experience” OR UX AND app OR application. The final set consisted of 10 publications. According to the Scopus Database, there was a significant increase in research studies on this topic from 2012 to 2022. The trend has continued to increase, indicating that research on design thinking approaches in UX design has become a hot topic for research and discussion. This paper found that Design Thinking is an essential component of user experience design and is used across various topics and industries. However, graphic design remains an unexplored area for research, presenting opportunities for further study.
Keywords: design thinking, user experience, systematic literature review
Strategy to Build Word-of-mouth in Increasing Bandung City Tourism Through City Tour Bus Services Quality
Authors: Syafyqoh Nahdah , Safira Anisa Putri , Wirasari Ira , Barlian Yelly Andriani
Published: January 2025

As the capital of West Java Province, Bandung City has a strong identity as a Tourism City. For tourists who want to get around the city while getting to know history, the Bandung City government created the Bandung on Tour Bus (Bandros). However, there are obstacles in the management system of Bandros as a city tour bus, especially in the field of service management. As a result, people who have ridden Bandros have unpleasant experiences and create negative word-of-mouth about Bandros. This study aims to design a design strategy to improve community word-of-mouth towards Bandros management. The research method used in this study used the design thinking ‘double diamond’ method. Primary data collection used observation of research objects, structured interviews with Bandros workers, and questionnaires with differential semantic calculation scales. Secondary data collection with literature study. The result of this study is a recommendation for strategies in improving Bandros services digitally through website design. So that with the improvement of service, it will form a positive word of mouth. This research is expected to produce management strategies for city tour bus services in increasing positive word-of-mouth in the community through a design approach.
Keywords: Bandros, city tourism, service quality, word-of-mouth
Combination of Industrial Style Elements With Cultural Elements of The Ancient Rumah Bolon in Residential Houses
Authors: Sipayung Angryani , Koesoemadinata Mohammad Isa Pramana , Wirasari Ira
Published: January 2025

The traditional houses of Indonesia are known for their unique architectural designs and interior decorations. One such example is that of the ancient Bolon houses, which refers to an Indonesian traditional house that is built on stilts and has a distinctive structure. However, due to the constant technological advancements of this era, most of the public tends to lean toward the current trend of modern interior design. The Modern Industrial style refers to a residential housing style that is widely admired by the public for its distinctive characteristics, namely the exposed materials utilized. In addition to the comparison between the house’s structure and material, the emphasis on functionality can be used as a starting point for the merging of these two architectural styles. The Modern Industrial style of architecture is known for its functionality and the Rumah Bolon had been built with specific functions in mind, such as the usage of the Balai Bolon for traditional ceremonies. Therefore, there is a requirement for a residential interior design concept that combines both modern and traditional styles, namely through the characteristics of the Modern Industrial style and that of the ancient Bolon Houses. The concept of this residential design aims to be an educational aid that shows the uniqueness of Indonesian traditional houses to the public.
Keywords: residential house, Rumah Bolon, industrial style, style combination, traditional style, merging
Meaning in motion: A kinesemiotic approach to videogame analysis in Street Fighter V
Authors: Maiorani Arianna , Hawreliak Jason
Published: January 2025

Videogames are a semiotically rich medium, capable of
utilizing virtually all modes of human expression (Ensslin
2012; Hawreliak 2018). Furthermore, they rely heavily
on visual signification practices and have historically been
the leading driver of advances in graphical technologies.
This makes them ideal objects of study when examining animation
trends, techniques, and representational practices. In
this paper, we propose a novel methodological approach to
analyzing animation in videogames, drawing on principles
of Multimodality (Kress and van Leeuwen 2021; Jewitt 2009;
Bateman, Wildfeuer, and Hiippala 2017) and Kinesemiotics
(Maiorani 2021). As a variegated research area that focuses on
communication across media, Multimodality provides a rich
theoretical background, especially in the domain of Kinesemiotics,
which focuses on movement-based communication
in natural, hybrid, and digital environments. Drawing on the
Functional Grammar of Dance (Maiorani 2017, 2021; Maiorani
and Liu 2022) and its implementation in manual and digital
annotation, the area of Kinesemiotics has expanded beyond
the study of dance discourse and towards performance analysis
in general, thus proving a flexible and adaptable approach.
This method has considerable potential for systematically analyzing
choreographed movements performed by characters in
videogame environments. To demonstrate the value of this approach,
we present a systematic analysis of movement in the
popular fighting game Street Fighter V: Championship Edition
(Capcom 2020), focusing on how gender-based stereotypes are
coded in character movements. By comparing the same movements
between female and male characters (e.g., a kick), we demonstrate how the game encodes gender norms through animation, i.e., how a
move is conveyed as ‘feminine’ or ‘masculine.’ We conclude the paper by examining
how representations on-screen are influenced by animation practices themselves,
including motion capture direction. This research presents a novel methodological
approach for investigating animation generally and has the potential to illuminate
unconscious bias in the animation industry.
The animation medium in the realm of Vocaloid: a multidimensional semiotic overview on the functional circle
Authors: Roussel Lila S.
Published: January 2025

The digital voicebanks/virtual idols known as ‘Vocaloids’
are associated with a vast and diverse repertoire of artifacts,
most of which are not industry-sourced but rather the
product of self-published hobbyist labor. Among the diverse
media through which Vocaloid culture has developed and
spread, the animation medium stands out for its variety of
uses and the multiplicity of affordances it provides. Not only
have the animation practices surrounding Vocaloid impacted
the objectual consumption of these entities both as musical instruments
and as virtual idol personas, but they have also given
rise to the development of new specialized software tools,
in addition to having propagated fandom-distinguishing subcultural
markers and genre-defining aesthetic orientations to
be found within the vast corpora of artistic productions utilizing
the Vocaloid technology and/or characters. This article examines
these practices from a semiotic perspective by reflecting
on their underlying technological and cultural conditions
of development and the manners in which they may serve as
both subcultural and genre-identifying signifiers in the resulting
repertoire of user/fan-generated media. It furthermore
looks at how the generation of and engagement with kinetic
scripts in the animation practices tied to Vocaloid are seen to
incorporate materialities that are exogenous to the medium
and considers the role of animation in the playful engagements
of users/fans with the virtual idol characters. Finally, it
examines some of the aesthetic features that particularly distinguish
the repertoire of Vocaloid music videos, most notably
in their recourse to principles of limited animation.
Exploration of Zakat Management Practices : A Qualitative study in Aceh's Mosques
Authors: Eka Octavian Pranata  , Hafiizh Maulana
Published: January 2025

Abstract
Zakat, one of the five pillars of Islam, plays a pivotal role in alleviating pov-erty and promoting social justice within Muslim communities. In Aceh, where Islamic values are deeply rooted, mosques serve as key institutions for zakat collection and distribution. This qualitative study explores the zakat management practices in Aceh’s mosques, examining how mosque leaders and community members understand, im-plement, and evaluate zakat programs. Through in-depth interviews with mosque ad-ministrators, religious leaders, and zakat beneficiaries, this study sheds light on the challenges and opportunities in improving zakat management. The findings highlight the importance of transparency, community participation, and institutional support for effective zakat distribution.
Strategi Pengelolaan Perpustakaan Dalam Meningkatkan Minat Baca Masyarakat Di Era Digital
Authors: Latifah Ainun Nurul , Sa’diyah Halimatus
Published: January 2025

Perpustakaan digital saat ini memiliki peran yang sangat penting karena mampu memenuhi kebutuhan masyarakat dengan mengakses informasi yang cepat dan mudah. Di era digital, masyarakat mengandalkan teknologi untuk mengakses berbagai sumber informasi tanpa batasan waktu dan tempat. Perpustakaan digital mempermudah masyarakat dalam mencari buku, jurnal, dan media lainnya. Penelitian ini bertujuan untuk menemukan beberapacara yang efektif untuk mengelola perpustakaan agar lebih menarik minat baca masyarakat di era digital. Metode yang digunakan dalam penelitian ini adalah metode penelitian kualitatif dengan pendektan studi pustaka.Peneliti mengumpulkan dan menganalisis informasi dari berbagai sumber seperti buku, jurnal, dan data dari perpustakaan. Hasil penelitian menunjukkan bahwa minat baca masyarakatdi Indonesia masih sangat rendah, dibandingkan dengan negara-negara majulainnya. Berdasarkan laporan World’s Most Literate Nations Ranked tahun 2016 menempatkan Indonesia di peringkat 60 dari 61 negara yang di survei. Adapun beberapa faktor yang menyebabkan rendahnya minat baca masyarakat seperti, kurangnya dukungan lingkungan dan keterbatasan akses terhadap buku. Untuk mengatasi masalah ini, perpustakaan harus mengadopsi strategi inovatif seperti digitalisasi koleksi, penyediaan akses online, dan pemanfaatan teknologi augmented reality (AR) serta virtual reality (VR). Implementasi teknologi ini bertujuan untuk membuat pengalaman membaca lebih interaktif dan menarik, terutama bagi generasi muda.
Analisis Potensi Peningkatan Minat Kunjung Pemustaka di Dinas Perpustakaan dan Kearsipan Kabupaten Bantul
Authors: Ari Kristanti Melisa , Santoso Budhi
Published: January 2025

This research was conducted at the Bantul Regency Library and Archives Service. The aim of this research is to analyze the increasing interest in visiting the Bantul Regency Library and Archives Service from year to year. This research uses qualitative descriptive methods with data collection techniques, namely Observation, Interviews, Documentation. Systematically observe and record the situation at the Library and Archives Service Bantul Regency and conducted interviews with librarians and several library visitors. This research proves what factors cause increased interest in visiting the Bantul Regency Library and Archives Service. The results of this research indicate that there are 2 factors increasing interest in visiting the Bantul Regency Library and Archives Service, namely Internal Factors and External Factors.
Ficções visionárias
Authors: Gaulês Murilo Moraes , Concílio Vicente , Imarisha Walidah
Published: January 2025

O presente artigo explora o conceito de ficção visionária, criado pela artista e abolicionista penal Walidah Imarisha, e seus desdobramentos em processos de pesquisa e criação de linguagem nas artes cênicas, no contexto do abolicionismo penal. O texto também contém uma entrevista com a autora após a realização do espetáculo Anjos de Cara Suja, primeira experimentação de ficção visionária no teatro no Brasil.
O espaço vivo como potência criativa no projeto teatral Barro
Authors: Doles Júnior Carlos Alberto , Cruz Hugo Alvez
Published: January 2025

Este artigo procura refletir acerca da influência do Espaço Vivo em processos de criação coletiva no teatro ativados no contexto de práticas artísticas participativas e comunitárias. Para tal foca-se no projeto teatral Barro onde o espaço de uma antiga cerâmica desempenhou um papel fundamental no processo criativo principalmente no que tange o trabalho das/os atuantes.
Experimentos em Teatro Político na Escola Popular de Teatro Político de Alagoas
Authors: Gianini Marcelo
Published: January 2025

Relato de curso de formação político-estética na linguagem teatral realizado pela Escola Popular de Teatro Político de Alagoas, em parceria com o MST, Laboratório Alagoano de Teatro do Oprimido e Universidade Federal de Alagoas (Ufal) em 2022. O processo pedagógico foi estruturado em quatro linhas de ação artística de Teatro Político: Artivismo, Peça Didática de Bertolt Brecht, Teatro do Oprimido e Agitação e Propaganda.
Narrativas corpóreas
Authors: Laurentino Mariane , Rosseto Robson
Published: January 2025

Este estudo investigou o potencial do Estímulo Composto de John Somers como mediador para envolver pessoas cegas e com baixa visão nas práticas teatrais, utilizando suas experiências como inspiração para criar narrativas cênicas. A estratégia revelou-se eficaz para promover a participação no teatro, ampliando as abordagens metodológicas e os repertórios de pessoas com deficiência visual em relação aos signos teatrais.
Tempo de cuidado e escuta
Authors: Ragazzon Patricia Avila
Published: January 2025

O texto compartilha um estudo sobre corpo, neurodiversidade e processos de criação, a partir da abordagem de composições performativas. A neurodiversidade aqui é vista fora de modelos clínicos de desordem e patologização, mas alinhada a diferentes percepções da experiência. A escrita busca repensar padrões de normatização de corpos e políticas de afeto acessíveis, através de um tempo de maior cuidado e escuta para todas as pessoas.
Mineralogia da ocorrência de possível “pseudoleucita” em Rio das Ostras, estado do Rio de Janeiro
Authors: Chaves Mario Luiz Sá Carneiro , Queiroz Luíza Almeida Villar de , Brandão Paulo Roberto Gomes , Henriques Andréia Bicalho , Menezes Sebastião de Oliveira
Published: January 2025

Introdução e Objetivo. O agregado mineral conhecido como “pseudoleucita” foi primeiramente descrito no Brasil, no Maciço Alcalino de Tinguá (município de Nova Iguaçu, Rio de Janeiro), constituindo a substituição completa da leucita original pela assembleia formada por ortoclásio, nefelina e analcima, mantendo a simetria cúbica do mineral pretérito. Metodologia. Entre outras localidades brasileiras, pseudoleucitas foram descritas no Maciço Alcalino do Morro de São João, município de Casimiro de Abreu. Nas proximidades deste último, cristais perfeitos de possíveis pseudoleucitas foram ainda encontrados em um dique de rocha alcalina na área central de Rio das Ostras, aqui estudados por densimetria, MEV-EDS, Espectroscopia RAMAN, FTIR e DRX. Resultados. No entanto, densidade baixa (~2,415), presença exclusiva de Al, Si e hidroxila, além de ser determinado o predomínio das fases dickita e caulinita, indicam uma nova e forte alteração do material original. Este novo processo envolve provavelmente uma ação hidrotermal tardia, além de meteorização. Conclusão. O fenômeno de duplo pseudomorfismo permite propor a invulgar designação “pseudo-pseudoleucita”, ou “pseudoleucita II” para o material.
Formação continuada de professores em Geociências para construção de um olhar geocientífico sobre o lugar
Authors: Carvalho Caroline Neves de , Campos Carlos Roberto Pires , Motta Fabíola de Abreu Quintino , Suanno Sérgio Benachio
Published: January 2025

Introdução. Este estudo apresenta uma discussão sobre as relações entre o ensino das Geociências e os espaços de educação não formal do município de Vila Velha (ES). Objetivo. Com foco na construção de um olhar geocientífico sobre o lugar, foram analisados os resultados de uma formação continuada de professores ofertada na Jornada da Integração Científica 2023, no Campus Vila Velha, do Instituto Federal do Espírito Santo, intitulada Espaços potencialmente educativos do município de Vila Velha, ES, que destacou a importância do patrimônio natural e arquitetônico local para o ensino de fundamentos de Geologia para professores. Metodologia. O estudo tratou-se de uma investigação qualitativa, do tipo estudo de caso, a coleta de dados ocorreu a partir da observação participante e a análise de conteúdo foi escolhida para realizar a discussão dos dados. Resultados. Os resultados corroboraram a possibilidade de inserção dos conteúdos geocientíficos no contexto discente e de criação de um espaço coletivo de reflexão sobre as práticas didáticas docentes. Conclusão. A formação de professores ofertada pôde avançar na construção de uma consciência ambiental dos participantes, por meio do reconhecimento do lugar, incentivando o desenvolvimento de práticas pedagógicas no e para o ambiente local.
Projeto Educação
Authors: Arsego Diogo Alessandro , Lima Rosemary Aparecida Odorizi , Vieira Carolina Freire , Thomaz Junior José Celso , Campos Antonio Marcos Vianna
Published: January 2025

Introdução. O Instituto Nacional de Pesquisas Espaciais tem como uma de suas missões formar pessoas e contribuir para o avanço do conhecimento ambiental no Brasil. Objetivo. Neste contexto, foi criado em 2017 o Projeto Educação: Extensão Educacional Científica, Ambiental e Tecnológica que, desde então, em parceria com o Núcleo de Educação Regional de Educação de Guaratinguetá, realiza palestras e oficinas com alunos de ensino fundamental e médio além da capacitação de professores em municípios do Vale do Paraíba em São Paulo. Metodologia. Neste trabalho são apresentados os fundamentos, métodos e algumas das ações deste projeto. Resultados e Conclusão. Até o fim de 2023, o projeto educacional atendeu mais de 3.200 pessoas entre alunos e professores, em sua ampla maioria da rede pública de ensino. Os resultados mostram que os professores agregam conhecimento ao participarem do curso de capacitação oferecido e que as palestras e oficinas desenvolvidas nas escolas despertam maior curiosidade dos alunos nas temáticas de ciência, tecnologia e meio ambiente.
Nova versão da maquete 3D da Bacia do Paraná para ensino e difusão das Geociências
Authors: Silveira Myatã Cardoso da , Carneiro Celso Dal Ré , Machado Leonardo Mendes Ribeiro
Published: January 2025

Introdução. Modelos tridimensionais da Bacia do Paraná produzidos anteriormente pelo grupo de pesquisa foram retrabalhados, para eliminar uma imprecisão: o risco de empenamento na fabricação das peças mais espessas: o Embasamento e o Paleozoico. Ambas não podem ser compactas (sólidas), na impressão do modelo físico digital 3D. Objetivo. O artigo descreve procedimentos, etapas de desenvolvimento e detalhes de operação dos programas Meshmixer, 3D Builder e Blender. Metodologia. Foram criados moldes ocos com adição de estruturas internas e suavização de superfícies, para garantir qualidade e precisão. Resultados. A impressão foi realizada na máquina Selective Laser Sintering (SLS), que trabalha com pó de nylon sinterizado. Além dos modelos, foram produzidos dois roteiros, que buscam: (a) auxiliar a criação de novos modelos 3D e (b) agrupar informações importantes, para uso educacional, sobre a bacia do Paraná e os modelos. Conclusão. Pretende-se inserir tais conceitos nas escolas, com a produção de mais cópias para que o projeto mostre o potencial das tecnologias de impressão 3D na criação de materiais didáticos, sublinhando assim o seu papel como ferramenta educacional.
Artificial intelligence versus human researcher performance for systematic literature searches: a study focusing on the surgical management of base of thumb arthritis
Authors: Seth Ishith , Lim Bryan , Xie Yi , Ross Richard J. , Cuomo Roberto , Rozen Warren M.
Published: January 2025

Aim: In the digital age, artificial intelligence (AI) platforms have gradually replaced traditional manual techniques for information retrieval. However, their effectiveness in conducting academic literature searches remains unclear, necessitating a comparative assessment. This study examined the efficacy of AI search engines (Elicit, Consensus, ChatGPT) vs. manual search for literature retrieval, focusing on the surgical management of trapeziometacarpal osteoarthritis.

Methods: The study was executed per the Cochrane Handbook for Systematic Reviews and PRISMA guidelines. AI platforms were given relevant keywords and prompts, while manual searches used PubMed, Cochrane CENTRAL, Web of Science, and Scopus databases from January 1901 to April 2024. The study focused on English-language randomized controlled trials (RCTs) comparing surgical management of trapeziometacarpal osteoarthritis (TMCJ OA). Two independent evaluators screened and extracted data from the studies. Primary outcomes involved the quality and relevancy of studies chosen by both search methods, evaluated by false positive rates and number of studies, including outcomes of interest.

Results: The manual search yielded the most results (6,018), followed by Elicit (4,980), Consensus (3,436), and ChatGPT (6). Elicit identified the highest number of RCTs (205) but also had the greatest false positive rate (94%). Ultimately, the manual search identified 23 suitable studies, Elicit found 10, Consensus found 9, and ChatGPT identified only 1. No additional studies were found by AI search engines that were not discovered in the manual search.

Conclusion: The findings highlight the potential advantages and drawbacks of AI search engines for literature searches. While Elicit was prone to error, Consensus and ChatGPT were less comprehensive. Significant enhancements in the precision and thoroughness of AI search engines are required before they can be effectively utilized in academia.
Five mile in and two thousand feet up: Early providers navigating transitions into rural medical practice
Authors: Hugs Josiah ,   Montana Family Medicine Residency, Ding Clio , Corrales Maria
Published: January 2025

In this study, we explored the transition experiences of recently graduated providers into rural clinical practice to understand their ongoing transition support and wellbeing needs. The study used Jindal-Snape’s Multiple and Multi-dimensional Transitions Theory and Gordon et al.’s Transition-To-Trained-Doctor (T3D) conceptual model as the foundation to explore early providers’ transitions to rural practice. It ultimately aimed to identify key factors that can help develop multi-dimensional support systems as providers transition into rural healthcare roles. We interviewed physicians, nurse practitioners, and physician assistants at two time points to better understand their longitudinal multiple and multi-dimensional transitions in their first three years of practice.

This comic anthology presents the interpretations of interview data from the providers. The comics present composite narratives of different participants. The visualization of the data through comics provides opportunity to explore the complexity of these transitions and to reach a wider audience who are an important part of the communities that support providers in their transitions to rural practice.
Numerical Modeling of CO2 Reduction Reaction in a Batch-Cell with Different Working Electrodes
Authors: Ijaz Ahmad , Mostafayi SeyedSepehr , Esmaeilirad Mohammadreza , Asadi Mohammad , Abbasian Javad , Arastoopour Hamid
Published: January 2025

Batch-cell provides a quick way to test the performance of an electrochemical catalyst. A fundamental understanding of physics behind the batch-cell operation could shed light on parameters that either could be fine-tuned to get the desired performance, or by careful optimization, overall performance of the batch-cell could be improved. Therefore, a one-dimensional numerical model is developed to study the electrochemical CO2 reduction reaction in a batch-cell with three different working electrode configurations: solid electrode, glassy carbon electrode, and gas diffusion layer electrode. Experimental results of two Cu-based catalysts are used to obtain the electrochemical kinetic parameters, and to validate the numerical model. Simulation results demonstrate that both gas diffusion layer electrode, and glassy carbon electrode with porous catalyst layer have a superior performance over solid electrode in terms of total current density. Furthermore, we studied the impact of key parameters of batch-cell with glassy carbon electrode such as boundary layer thickness, catalyst layer thickness, catalyst layer porosity, electrolyte nature, and strength of an electrolyte on total current density at a fixed applied cathodic potential of -1.0 V vs RHE.
Deep Learning Workflow and Dataset for Deep Learning Image Classification of Ulcerative Colitis and Colorectal Cancer
Authors: Carreras Joaquim , Roncador Giovanna , Hamoudi Rifat
Published: January 2025

Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract characterized by the deregulation of immuno-oncology markers. IBD includes ulcerative colitis and Chron disease. Chronic active inflammation is a risk factor for the development of colorectal cancer (CRC). Deep learning is a form of machine learning that is applicable to computer vision, and it includes algorithms and workflows used for image processing, analysis, visualization, and algorithm development. This publication describes a dataset of histological images of ulcerative colitis, colorectal cancer (adenocarcinoma), and colon control. The samples were stained with hematoxylin and eosin, and immunohistochemically analyzed for LAIR1 and TOX2. The methods used for collecting and producing the data, analysis using convolutional neural networks (CNNs), where the dataset can be found, and information about its use are also described. This paper is the companion manuscript of the recently published article “Ulcerative Colitis, LAIR1 and TOX2 Expression, and Colorectal Cancer Deep Learning Image Classification Using Convolutional Neural Networks” published in Cancers 2024, 16, 4230. https://doi.org/10.3390/cancers16244230.
Prognostic Role and Determinants of Ascending Aorta Dilatation in Non-Advanced Idiopathic Pulmonary Fibrosis: A Preliminary Observation from a Tertiary University Centre
Authors: Sonaglioni Andrea , Caminati Antonella , Behring Greta , Nicolosi Gian Luigi , Rispoli Gaetana Anna , Zompatori Maurizio , Lombardo Michele , Harari Sergio
Published: January 2025

Background: No previous study was specifically focused on the ascending aorta (AA) diameter assessment in patients with idiopathic pulmonary fibrosis (IPF). The aim of this study was to investigate the prognostic role of the AA diameter in patients with mild-to-moderate IPF and to identify the main determinants of the AA dilatation. Methods: All IPF patients without severe pulmonary hypertension who underwent a multi-instrumental evaluation, comprehensive of high-resolution computed tomography (HRCT) and transthoracic echocardiography (TTE), between September 2017 and No-vember 2023, were retrospectively analyzed. The primary endpoint was the composite of “all-cause mortality or re-hospitalization for all causes”, over a medium-term follow-up. The secondary endpoint was to evaluate the independent predictors of AA dilatation. Additionally, Bland-Altman analysis was used to assess the accuracy and precision of echocardiography-derived AA diameters compared with non-ECG gated HRCT meaurements. Results: A total of 105 IPF patients and 102 age-, sex- and cardiovascular risk factors-matched controls without IPF were retrospectively evaluated. Over a follow-up of 3.9±1.9 yrs, 31 patients died and 47 were re-hospitalized. AA/height (HR 1.15, 95% CI 1.06-1.25, p < 0.001) was independently associated with the primary endpoint, whereas unindexed AA (HR 1.01, 95% CI 0.96-1.06, p = 0.83) and AA/BSA (HR 1.00, 95% CI 0.89-1.11, p = 0.39) were not. An AA/height >20 mm/m showed 100% sensitivity and 63% specificity (AUC = 0.78) for predicting the primary endpoint. C-reactive protein (OR 1.87; 95% CI 1.21-2.89, p = 0.005) and left ventricular mass index (OR 1.13, 95% CI 1.04-1.24, p = 0.006) were independently associated with an AA/height >20 mm/m in the whole study group. The Bland-Altman analysis revealed a bias of +2.51 mm (with the 95% limits of agreement ranging –3.62 to 8.65 mm) for AA estimation, suggesting a general overestimation of the AA diameter by TTE in comparison to HRCT. Conclusions: The AA dilatation is predictive of poor outcome in IPF patients without advanced lung disease, over a mid-term follow-up. The AA/height assessment may improve the prognostic risk stratification of IPF patients.
Characteristic Fragmentation Behavior of Linear and Cyclic O-Linked Glycopeptide and Their Peptide Skeletons in MALDI-TOF/TOF MS
Authors: Fukushi Kohki , Urakami Shogo , Hinou Hiroshi
Published: January 2025

O-linked glycopeptides have attracted attention because of their ability to control peptide conformation and function via glycosylation. Cyclic peptides have also attracted attention for their various physiological and physical activities, owing to the conformational constraints associated with cyclization. We found that cyclic antifreeze glycopeptides showed characteristic peptide chain fragmentation patterns in the MALDI-TOF/TOF MS analysis. The fragmentation patterns were characterized by the parallel occurrence of side-chain fragmentation of threonine residues and fragmentation within the macrocyclic peptide bond associated with ring opening. Furthermore, the tendency for side chain fragmentation was altered depending on the adduct ions, the presence or absence of glycans, and the substitution of threonine with serine. These fragmentation mechanisms have been suggested to be influenced by conformational changes in cyclic peptides, along with adduct ion coordination or structural modifications, particularly threonine residues. This finding is expected to contribute to the prediction of peptide conformation based on fragmentation tendencies and to the search for physiologically active O-linked glycopeptides and cyclic (glyco)peptides.
Radiological and Immunohistochemical Characteristics of PitNETs in 79 Patients Undergoing Neurosurgery
Authors: Krzentowska Anna , Czepko Ryszard , Adamek Dariusz , Filipowicz Michał , Broniatowska Elżbieta , Gołkowski Filip
Published: January 2025

Objective: The objective of the study was to provide radiological and immunohistochemical evaluation of pituitary neuroendocrine tumors (PitNETs) concentrating on their invasiveness, endocrine function and expression of transcription factors. Methods: 79 cases of PitNETs were analyzed. The analysis included their MRI features, invasiveness and immunophenotype (immunoexpression of transcription factors Pit-1, SF1, TPit and the hormones). Results: Tumors from the SF1 line were statistically significantly more likely to show a tendency to invade the sella turcica (p<0.0001), while tumors from the Pit-1 and TPit factor lines were demonstrated to be both invasive and non-invasive, and the difference was not statistically significant. No statistically significant difference was found in the invasion of the cavernous sinuses by the pituitary tumors regardless of the transcription factor from which they originated. No statistically significant differences were observed between hormonally active and inactive tumors in terms of gender, age, invasiveness, size, or volume. Conclusions: PitNETs, also known as pituitary adenomas, continue to represent a significant challenge for clinicians. Tumors from the SF1 factor line are characterized by a statistically significantly more frequent invasion directed towards the sella turcica, while tumors from the Pit-1 and TPit lines do not show such a relationship. Patients with corticotroph PitNETs need to be controlled due to the proclivity of the tumors for aggressive behavior. Other types of PitNETs are less common. Tumors that express multiple transcription factors necessitate the patient to be subjected to further diagnostic and investigative procedures.
An Osteoblast-Specific Enhancer and Subenhancer Cooperatively Regulate Runx2 Expression in Chondrocytes
Authors: Matsuo Yuki , Qin Xin , Moriishi Takeshi , Kawata-Matsuura Viviane K. S. , Komori Hisato , Sakane Chiharu , Yabuta Suemi , Jiang Qing , Kaneko Hitomi , Ito Kosei , Shigeta Mayo , Abe Takaya , Komori Toshihisa
Published: January 2025

Runx2 is an essential transcription factor for osteoblast differentiation and chondrocyte maturation. The spaciotemporal expression of Runx2 is regulated by enhancers. We previously identified a 1.3-kb osteoblast-specific enhancer; however, mice with its deletion showed no phenotypes. A 0.8-kb conserved region detected near the 1.3-kb enhancer did not exhibit enhancer activity in reporter assays, whereas four tandem repeats of 452 bp (452×4), containing the most conserved region of 0.8 kb, induced strong reporter activity in chondrocyte cell lines. However, the chondrocytes of enhanced green fluorescent protein (EGFP) reporter mice using 452×4 did not express EGFP. When 452×4 was combined with the 1.3-kb enhancer, hypertrophic chondrocytes highly expressed EGFP. Moreover, the 0.8-kb region combined with the 1.3-kb enhancer induced EGFP expression in prehypertrophic and hypertrophic chondrocytes. The deletion of both the 1.3-kb enhancer and 0.8-kb conserved region slightly reduced Runx2 expression in the limbs. However, neither homozygous nor heterozygous deletions in the Runx2+/– background showed phenotypes. The 0.8-kb conserved region itself lacked enhancer activity, but when combined with the 1.3-kb enhancer, EGFP expression was induced in chondrocytes with a similar expression pattern to Runx2. Therefore, the 0.8-kb conserved region has a novel function as a subenhancer.
Underground Hydrogen Storage: Transforming Subsurface Science into Sustainable Energy Solutions
Authors: Opoku Duartey Kwamena , Ampomah William , Rahnema Hamid , Mehana Mohamed
Published: January 2025

As the global economy moves toward net-zero carbon emissions, large–scale energy storage becomes essential to tackle the seasonal nature of renewable sources. Underground hydrogen storage (UHS) offers a feasible solution by allowing surplus renewable energy to be transformed into hydrogen and stored in deep geological formations such as aquifers, salt caverns, or depleted reservoirs, making it available for use on demand. This study thoroughly evaluates of UHS concepts’, procedures, and challenges. The paper analyzes the most recent breakthroughs in (UHS) technology and identified special conditions needed for its successful application, including site selection guidelines, technical and geological factors, and the significance of storage characteristics. The integrity of wells and caprock, which is important for safe and efficient storage, can be affected by the operating dynamics of the hydrogen cycle, notably the fluctuations in pressure and stress within storage formations. To evaluate its potential for broader adoption, we also examined economic elements such as cost-effectiveness and the technical practicality of large-scale storage. We also reviewed current UHS efforts and identifies key knowledge gaps, primarily in the areas of hydrogen-rock interactions, geochemistry, gas migration control, microbial activities and geomechanical stability. Resolving these technological challenges, regulatory frameworks and environmental sustainability are essential to UHS’s long-term and extensive integration into the energy industry. This article provides a roadmap for UHS research and development, emphasizing the need for further research to fully realize the technology’s promise as a pillar of the hydrogen economy.
Analysis of Aging and Degradation in Lithium Batteries Using Distribution of Relaxation Time
Authors: Sohaib Muhammad , Akram Abdul Shakoor , Choi Woojin
Published: January 2025

In this paper, the deconvolution of Electrochemical Impedance Spectroscopy (EIS) data into the Distribution of Relaxation Times (DRT) is employed to provide a detailed examination of degradation mechanisms in lithium-ion batteries. Using an nth RC model with Gaussian functions, the study achieves enhanced separation of overlapping electrochemical processes where Gaussian functions yield smoother transitions and clearer peak identification than conventional piecewise linear functions. The advantages of employing Tikhonov Regularization (TR) with Gaussian functions over Maximum Entropy(ME) and FFT methods are highlighted as this approach provides superior noise resilience, unbiased analysis, and enhanced resolution of critical features. This approach is applied to LIB cell data to identify characteristic peaks of DRT plot and evaluate their correlation with battery degradation. By observing how these peaks evolve through cycles of battery aging, insights into specific aging mechanisms and performance decline are obtained. The study combines experimental measurements with DRT peak analysis to characterize the impedance distribution within LIBs which enables accelerated detection of degradation pathways and enhances the predictive accuracy for battery life and reliability. This comprehensive analysis contributes to a refined understanding of LIB degradation behavior, supporting the development of advanced battery management systems designed to improve the safety, to optimize the battery performance, and to extend the operational lifespan of LIBs for various applications.
Antiviral Coatings, from the Narrative to Visible Light Active Films
Authors: Innocenzi Plinio
Published: January 2025

The increasing need for effective antiviral strategies has led to the development of advanced surface coatings to combat the transmission of viruses via fomites. The Covid-19 pandemic has dramatically stimulated research in the field, and numerous advances have been made in understanding virus-surface interactions. A crucial step has been the experimental study of viral infection due to interactions with fomites. The alarm created by the pandemic, including the initial uncertainty about the mechanisms of infection spread, put the focus on fomites as a possible cause of virus transmission. Later research showed, however, that such a mechanism is implausible. The knowledge gained about fomites during the pandemic can be used to develop a new generation of biocidal coatings for bacteria and viruses that surfaces can actually transmit. In particular, biocidal coatings photoactivated by visible light represent a promising opportunity.
Effective Data Augmentation Techniques for Arabic Speech Emotion Recognition Using Convolutional Neural Networks
Authors: Bouchelligua Wided , Al-Dayil Reham , Algaith Areej
Published: January 2025

This paper investigates the effectiveness of various data augmentation techniques for enhancing Arabic Speech Emotion Recognition (SER) using Convolutional Neural Networks (CNNs). Utilizing the Saudi Dialect and BAVED datasets, we address the challenges of limited and imbalanced data commonly found in Arabic SER. To improve model performance, we apply augmentation techniques such as noise addition, time shifting, increasing volume, and reducing volume. Additionally, we examine the optimal number of augmentations required to achieve the best results. Our experiments reveal that these augmentations significantly enhance the CNN's ability to recognize emotions, with certain techniques proving more effective than others. Furthermore, the number of augmentations plays a critical role in balancing model accuracy. The Saudi Dialect dataset achieved its best results with two augmentations (increasing volume and decreasing volume), reaching an accuracy of 96.81%. Similarly, the BAVED dataset demonstrated optimal performance with a combination of three augmentations (noise addition, increasing volume, and reducing volume), achieving an accuracy of 92.60%. These findings indicate that carefully selected augmentation strategies can greatly improve the performance of CNN-based SER systems, particularly in the context of Arabic speech. This research underscores the importance of tailored augmentation techniques to enhance SER performance and sets a foundation for future advancements in this field.
Non-Invasive Biomarkers for Early Diagnosis of Kidney Allograft Dysfunction. Current and Future Applications in the Era of Precision Medicine
Authors: Lazarou Christina , Moysidou Eleni , Christodoulou Michalis , Lioulios Georgios , Fylaktou Asimina , Stangou Maria
Published: January 2025

Kidney transplantation stands as the preferred treatment for end-stage kidney disease, significantly improving both the quality and longevity of life compared to dialysis. In recent years, the survival rates for patients and grafts have markedly increased thanks to innovative strategies in desensitization protocols for incompatible transplants and advancements in immunosuppressive therapies. Although the initial expenses associated with transplantation may exceed those of dialysis, it proves to be more cost-effective in the long run.
Despite its numerous benefits, the widespread adoption of kidney transplantation faces several challenges, notably a scarcity of donated organs, financial limitations, and unequal access among various populations. Additionally, there is a shortage of healthcare professionals equipped with the requisite expertise.
For kidney transplant recipients, preventing allograft rejection is of paramount importance, necessitating the use of immunosuppressive medications. Regular follow-up appointments are essential, as monitoring the function of the kidney allograft is critical. Currently, established biomarkers such as serum creatinine, estimated Glomerular Filtration Rate (eGFR), proteinuria, and albuminuria are commonly employed to assess allograft function. However, these biomarkers have limitations, as elevated levels often indicate significant allograft damage only after it has occurred, thereby constraining treatment options and the potential for restoring graft function. Additionally, kidney biopsies, while considered the gold standard for diagnosing rejection, are invasive and carry associated risks. Consequently, the identification and development of new, sensitive, and specific biomarkers for allograft rejection are crucial. To tackle this challenge, intensive ongoing research employing cutting-edge technologies, including “omics” approaches, is uncovering a variety of promising new biomarkers.
Application of Wearable Sensors in Parkinson’s Disease: Future Prospective
Authors: Bougea Anastasia
Published: January 2025

(1) Background: Wearable sensors have emerged as a promising technology in the management of Parkinson's Disease (PD). These sensors can provide continuous and real-time monitoring of various motor and non-motor symptoms of PD, allowing for early detection and intervention. In this abstract, i review current research on the application of wearable sensors in PD, focusing on gait, tremor, bradykinesia, and dyskinesia monitoring. (2) Methods: This is a literature research spanning the 2000-2024 period including the following keywords: “wearable sensors”; “Parkinson’s Disease”; “Inertial sensors” , accelerometers’’, ‘’gyroscopes’’, ‘’magnetometers” , “Smartphones” , “Smart homes”. (3) Results: Despite favorable outcomes from the early development of inertial sensors like gyroscopes and accelerometers in smartphones, application of DB is still restricted because there are no standards, harmonization, or consensus for both clinical and analytical validation. As a result, several clinical trials have been created to compare the effectiveness of DB with conventional evaluation methods in order to track the course of the disease and enhance quality of life and results. (4) Conclusions: Wearable sensors hold great promise in the management of PD and are likely to play a significant role in future healthcare systems.