bluuebunny/crossref_metadata_2025 huggingface dataset:
Territory Development Strategy: Strategist and Information
Authors: Ivanova S. A.
Published: May 2019

Issues related to the nature of information in the context of the development of a territory growth strategy are presented in the article. A brief analysis of the terms such as information, strategy, plan is made. It is revealed that the information, plan and strategy are complex and fluctuating. Some features of human perception of information are considered. The specificity of the thinking paradigms influence on human perception of information is also presented.The modern world represents sets of emergent properties that are precisely the result of continuous information influence in their essence and generate new states of the system, and therefore new meanings. A strategist interacts with a rapidly changing context; he should be able to make management decisions taking into account the redundant and incomplete nature of the information. These decisions should lead to the achievement of goals. Such a task is not simple at all and requires certain skills in working with information. The method of working with information is infology. It provides a set of relevant procedures that allow you to solve the problem of collecting and processing information at a qualitatively new level. Thus, the algorithms for working with information allow you to collect comprehensive information on the capabilities, needs and resources of the territory and link them into a single plan for achieving the goal. And that means they allow you to improve the quality of planning by reference to the strategic goals of the territories.The strategist becomes a hunter of meanings to a certain extent; this ability allows him to see the general picture of local development from the maximum advantageous position. The strategist begins to possess Femostokl’s unique ability and to know how to “do absolutely right things at the right moment,” that is, to program the desired behavior, involve and sensitize people to achieve a single goal, and then enable these goals to be realized by everyone involved in the process. And this requires not only the information, but its deep understanding and using ability to achieve the goals. Data can become the working information only if you work hard and find meanings that are important for understanding the features of a managed object. Thus, understanding the facts that are behind the reality displays allows you to change the quality of management and development of a territory growth strategy.
Partial sums of hyper-Bessel function with applications
Authors: AKTAŞ İbrahim
Published: May 2019

The main purpose of the presented paper is to determine some lower bounds for the quotient of the normalized hyper-Bessel function and its partial sum, as well as for the quotient of the derivative of normalized hyper-Bessel function and its partial sum. In addition, some applications related to the obtained results are given.
ASPECT OF MINIMIZATION AREAS OF «HUMAN FACTOR» IN LABOR SAFETY
Authors: BOCHKOVSKYI A. , SAPOZHNIKOVA N.
Published: May 2019

The article analyzes well-known semantic interpretations of the term "human factor" in the context of the evolutionary development of the safety component in "man-machine-environment" systems. It has been ascertained that single, recognized by law term "human factor" still does not exists, but the majority of researchers attribute this phenomenon to the human psycho-physiological reaction to changes in the environment. It is noted that this approach is erroneous because the manifestations of "human factor" at the individual level of each person should be considered in the context of the features of its three main components - biological, social and informational. The trends of the evolutionary development of the technosphere and the analysis of statistical data on occupational accidents, as well as industrial breakdowns and disasters, prove the need to introduce positive changes at the level of the "human factor" components. First of all, it concerns the information component, as the development of technologies over the past decade is far ahead of the level of training in the field of occupational safety, which does not allow maintaining the required level of occupational safety and labor culture in the conditions of a new range of previously unknown hazardous and harmful production factors. It was emphasized that necessary positive changes in the components of the "human factor" should be implemented as a part of the concept of sustainable humanity development, which provides for the development of three interrelated areas: economic, social and spiritual growth of society. Thus, basic directions that will minimize the negative effects of the "human factor" within functioning of the future complex systems "man machine-environment", are to increase the level of motivation for safe human behavior at production facilities and to form safety priorities over economic outcomes of enterprise’s activity. The possibility to implement such directions directly depends on the implementation of the relevant reforms in the system of secondary, vocational and higher education, as well as occupational safety and industrial safety regulatory framework in Ukraine.
ANALYSIS OF THE QUALITY OF FLOUR FROM DIFFERENT SYSTEMS OF THE TECHNOLOGICAL PROCESS OF A FLOUR MILL
Authors: ZHYGYNOV D. , KOVALOVA V. , DRAGOMYR A. , ZHYHUNOVA H. , ZHANABAYEVA К.
Published: May 2019

Research in the article is aimed to determining the quality of flour from different systems of the technological process of a wheat milling. Samples of flour were obtained at the mill "Rivne Boroshno". Private enterprise "Rivne Boroshno" is one of the largest producers of wheat flour in the western region with a capacity of 180 tons /day. Flour obtained from various systems of milling process, has a very large variety of quality indicators. Whiteness, Gluten Deformation Index, Gluten Content, Protein Content, Ash Content, Water Absorbing Capacity, FN, SD, the rheological properties of dough on the Mixolab device, as well as the quality of baked bread have been evaluated.During the study, the variability of flour quality indicators on various systems was found. Whiteness varied – from 1 to 71 units, Gluten Deformation Index – from 40 to 100 units, Gluten Content – from 2 to 36 %, Protein Content – from 9,8 to 18,2 %, the FN – from 275 to 374 s, SD – from 15 to 30,3 UCD, Ash Content – from 0,31 to 2,23 %, Water Absorbing Capacity – from 53,5 to69,7 %. In the process of grinding grain and intermediate products, more than twenty flour streams of different quality are producedat the flour mill. From these streams it is required to receive only one or several grades of flour. Naturally, if only one variety is produced, then all flows from different systems are sent to it. The weighted average quality indicators of flour should comply with the requirements of the standard for this grade in terms of Ash Content, Gluten Content, etc.The maximum Ash Content is observed in the streams from the last reduction systems, as well as from break systems in the milling process, where products with a large number of brans are milled. At the same time, the flour from the central parts of the endosperm is slightly less gluten, but more starch than in the flour from the peripheral parts of the endosperm, which are grinding on subsequent reduction systems. For the research, samples of flour were taken from each system of the technological process. For convenience, we have arranged them for quality using the indicator of whiteness. One of the main indicators of the quality of flour, which determines its grade, is whiteness. In the studied samples, the values of the whiteness index range from 71 to 1 unit.
CHLORELLA SUSPENSION AND ITS USAGE IN FINISHING PIGS’ RATIONS
Authors: KARUNKYI O. , REZNIK T. , KULIDZHANOV Ye
Published: May 2019

The animal husbandry cannot develop successfully without complete balanced feed and optimal forage supply. This article deals with the chemical composition of chlorella suspension. The ration is balanced with seaweeds as well as premixes, vitamins and bio supplement for the last decades. These seaweeds include chlorella - a representative of green microscopic algae. The use of chlorella allows for multi-factor balancing of the diet in accordance with modern feeding standards, which increases the productive effect of feed and significantly increases the transformation of nutrients into livestock products. This is arelevant issue of modern animal husbandry. The chlorella suspension was material for scientific research. It was made on the farm “In Samvel”, Ovidiopol District. According to the result of researches that took place on the farm " In Samvel", Biliayevka District, Odessa Oblast and SERF "Yuzhnyi" OSAGES NAAS, new data concerning chemical composition, the positive influence of investigated chlorella suspension on the growth and development of finishing pigs as well as feed costs by 1 kg of growth were obtained. It has been established that the chemical composition of chlorella suspension takes a special place among all feed additives used in farm animals feeding. It has been established that the additional use of chlorella suspension in the ration of finishing pigs of Large White breeds contribute to the increase of average daily gains by 121.9% against the control group in which chlorella suspensions was not given. Feed conversion to obtain1 kg of pigs live weight gain in the control group was 5.1 kg, in the experimental group - 4.2 kg and feed conversion index in the experimental group was higher by 21.4%. Thus the results of researches indicate the positive effect of investigated chlorella suspension on the growth anddevelopment of finishing pigs. Due to the obtained results, we can state that the chemical composition of the suspension chlorella takes a special place among all feed additives used in farm animals feeding. Chlorella has higher indicators of chemical composition, the amount of protein, vitamins and minerals in comparison with plant fodder and crops of agricultural production.
EDUCATION: REAL AND DUE
Authors: Khmel V. V.
Published: May 2019

The current context of information society is characterized by the growing role and importance of educational technology. To the fore the question of what should be a process of education

in the postmodern situation and on the basis of the Bologna concept. The article contains a comparative analysis of educational systems of Germany, Russia and Ukraine.
Postmodern and Natural Myth: Points of Contact and Conflict Situations
Authors: N. V. Devjatko
Published: May 2019

The article is devoted to the structures features of a modern myth and its natural capacity for national revival. The relationships and conflicts between the natural myth and postmodernism as worldview specific types of communication systems have been determined.
MODERN TRENDS INFORMATIONAL TECHNO-ENABLING TECHNOLOGIES OF PROFESSIONAL COMPETENCE IN THE HIGHEST EDUCATION IN THE CONTEXT OF ANTHROPOLOGICAL DEVELOPMENT
Authors: Mudrak V. I.
Published: May 2019

Modern approaches to the anthropology development in the global information space are realized in the system of technica - echnology provision of professional competence in the highest

education. This implies running time the newest relation systems in context “man-technetechnology- education-professional competence”.
INFLUENCE RESEARCH OF CHEMICAL COMPOSITION OF HIGH-VOLTAGE CIRCUIT DESIGNS ON THE FIRE BREAK-OUT AT THE LOCOMOTIVES
Authors: V. V. Kovalenko
Published: May 2019

Purpose. The work is aimed at identifying the influence of the incompatibility of chemical composition of the high-voltage circuits designs on the mechanism of fire break-out at the VL-80k locomotive. Methodology. Macro- and microstructural, fractographic, analytical analyses were applied during the research of the samples of contact clamps materials. Findings. Analytical analysis of the parts of electric locomotive made it possible to identify the primary causes of circuit-breaker oil ignition followed by a complete burnout of the locomotive section. It was established that the destroyed contact clamps had a chemical composition that does not meet the requirements of design and technical documentation. The arc formed between the edges of macro-cracks during the destruction of the contact clamps did not lead to the disconnection of the main high-voltage relay, and due to the high power contributed to the ignition of a large amount of circuit-breaker oil, which was located below the contact clamps. Such ignition may also occur as a result of the weakening of the locomotive power circuit caused by the vibration. One can prevent such cases of ignition by identifying critical heating temperatures of the contacts of high-voltage cabinet, contactor and resistor groups to immediately strengthen or replace the connection. Originality. A comprehensive analytical and technical approach was applied in identifying the causes of fire at the VL-80k electric locomotive. A typical fire break-out mechanism and a maximum number of factors that could affect the premature destruction of the contact clamps were investigated. It is shown that a set of factors that negatively affected the performance characteristics of the contact clamps, simultaneously reached the so-called "critical mass" as a result of heating of these defective parts. The introduction of additional signaling factors for supercritical heating of the investigated and other important parts and designs of locomotives will prevent fires at the locomotives. It will help timely to identify the inconsistency of the chemical composition of the parts of the design and technical documentation, as well as to find out the gaps in the electrical connections that were formed either due to the insufficient tightening, or due to the weakening of connections in the process of vibration during the movement of locomotives. Practical value. The proposed additional signaling will contribute not only to the preservation of the locomotive fleet of Ukrzaliznytsia OJSC, but also to the rescue of locomotive brigades.
PERIODONTITE AGRESSIVA: REVISÃO DE LITERATURA
Authors: Barbosa Renata De Araújo , Souza Sandro Bittencourt , Ribeiro Érica Del Peloso
Published: May 2019

The aggressive periodontitis (AgP) occurs on clinically health individuals, except for the presence of periodontal disease, is characterized by rapid attachment loss and bone destruction and also by family aggregation, among other secondary characteristics.  The rapid periodontal destruction observed in AgP is an extremely important factor and have raised the researchers attention all over the world, once one come across an infection characterized by a highly virulent microorganism and/or by highly susceptible individuals. The risk of tooth loss and function and esthetic compromising, mainly in young patients, more commonly affected by the AgP, also stimulates the search for answers and more efficient treatments in the disease control. Therefore, the aim of this study is to review the literature of aggressive periodontitis considering the findings in the microbial etiology and individual susceptibility, as well as its response to periodontal therapy and the search for alternatives that lead to benefits in the periodontal clinical parameters.
PARTICIPAÇÃO DOS MASTÓCITOS NO REPARO TECIDUAL E EM LESÕES INFLAMATÓRIAS BUCAIS – UMA REVISÃO DE LITERATURA
Authors: Correia Kariza Vargens , Medrado Alena Peixoto
Published: May 2019

Mast cells (MCs) are mobile cells that contain granules, derived from bone marrow and are widely distributed in tissues actively participating in immune responses. The involvement of these cells has been demonstrated in the inflammation, fibrosis and angiogenesis, in which they act through their secretory products. The purpose of this literature review is to address the involvement of MCs in biological phenomena that comprise the context of tissue repair, such as vasodilation, angiogenesis and fibrosis, with emphasis on the characterization of the profile of these cells in inflammatory lesions mouth. Although few studies contemplate the participation of MCs in oral lesions, some others have shown that these cells are involved in the pathogenesis of periapical lesions, aphthous ulcers, odontogenic cysts, among others. The advancement of knowledge about the mechanism of action of these cells, has stimulated the development of therapies whose chief aim is the regulation of chemical mediators released by mast cells. Therefore, it is hoped that through further investigations, inflammatory disorders of the oral cavity and other conditions that display interstitial MCs,might be better understood, mainly concern to MCs biological behavior.
REANATOMIZAÇÃO DENTAL COM RESINA COMPOSTA: RELATO DE CASO
Authors: Rodriguez Stephanie Dias Rivera , Argolo Saryta , Cavalcanti Andrea Nóbrega
Published: May 2019

Purpose: to present a case in which it was decided, as treatment plan, by bleaching followed by the preparation of semi-facet composite resin of the upper canines to return the dental anatomy. Case description: Male patient with a history of child bruxism, where the anatomical features of maxillary canines were lost, he seemed to be dissatisfied with the cosmetic appearance of your smile. The aesthetic resolution of this case was based on the bleaching employment and direct technique with the use of composite resin, to obtain a harmonious smile, observing the correct protocol based on the latest evidence presented in the literature, and the result has met the aesthetic expectations of the patient. Conclusion: Direct composite resin restorations are excellent for reshaping of anterior teeth, restoring and reproducing the shape, size and color of the teeth.
BIOMODULATORY POTENTIAL OF LOW-LEVEL LASER ON NEOANGIOGENESIS AND REMODELING TISSUE. A LITERATURE REVIEW
Authors: Fortuna Tila , Gonzalez Ana Cristina O. , Ferreira Maíra Sá , Reis Sílvia R. A. , Medrado Alena A. R. P.
Published: May 2019

Introduction: In recent years, cellular biostimulation induced by low-level laser therapy has been widely studied. Among some of the processes stimulated by low-level laser are cell cycle, phenotypic modulation as well as vascular changes, such as vasodilation and neoangiogenesis. The increased number of new blood vessels accelerates inflammation, and also increases wound healing. Neoangiogenesis is still an important process of tissue repair, since it always precedes collagen synthesis and matrix extracellular remodeling. Increasing scientific evidence has shown that photobiomodulation stimulates neoangiogenesis, fibroblast proliferation and collagen biosynthesis. Objective: Review the literature about the effects of low level laser therapy on neoangiogenesis and fibroplasia and describe how these processes occur in the tissue subjected to an injury. Methods and Matereials: The search tool used was the Medline / Pubmed and the following keywords were used: remodeling, wound healing, neoangiogenesis, fibroplasia, laser therapy, low-level laser. Manuscripts published from 1990 to 2017 were selected. Results: Increasing scientific evidence has shown that photobiomodulation stimulates neoangiogenesis, fibroblast proliferation and collagen biosynthesis. Conclusion: Neoangiogenesis always precedes collagen synthesis and matrix extracellular remodeling. However, little is known of the action of laser therapy in the late stages of tissue repair.
The clinical efficacy of BTK inhibitors in the treatment of CLL v1
Authors: Brown Alex
Published: May 2019

Studies of BTK as a target have enjoyed substantial popularity among the researcher circle ever since its role in B-cell maturation as well as in mast cell activation through the high-affinity IgE receptor have been confirmed, which given rise to the development of a diverse array of BTK inhibitors. Ibrutinib and Acalabrutinib are two BTK inhibitors that have already been approved for clinical use, while there are many other BTK inhibitors with published structures, such as Olmutinib, Tirabrutinib, Spebrutinib and more. CLL is the most common type of leukemia in adults. In the United States, it accounts for a quarter of the total number of new leukemia patients. Excessive hematopoietic stem cells in the bone marrow of CLL patients produce abnormal lymphocytes, and these abnormal cells do not normally fight infection. An increase in the number of abnormal cells simultaneously reduces the production of normal white blood cells, red blood cells, and platelets. This can lead to anemia, infection and bleeding. The BTK-mediated B cell receptor signaling pathway is an important signaling pathway for stimulating CLL growth. Calquence can inhibit BTK activity by covalent binding to BTK. The new drug has been approved by the FDA in 2017 for the treatment of adult patients with mantle cell carcinoma (MCL) who have received a pre-treatment.
RaPET®PCR v1
Authors: Alberto Garza-Garza Mario , Delgadillo Dealmy
Published: May 2019

Prueba de aglutinación de látex en placa para la determinación cualitativa y semi-cuantitativa de Proteína C Reactiva en suero no diluido.
Enhancing Students’ Creativity through STEM Project-Based Learning
Authors: Hanif Sofi , Wijaya Agus Fany Chandra , Winarno Nanang
Published: May 2019

In some school, teacher-centered is commonly found in the learning process. The learning process itself is still in the form of direct transfer of knowledge from teacher to students. Actually, students will learn better if they are engaged in meaningful learning activity.  STEM project-based learning is one of alternative teaching strategies that engaged students in meaningful learning. The aim of this study is to investigate the impact of STEM project-based learning on students' creativity in the topics of light and optics.  The study used qualitative research with narrative design. Data collection technique that used is observation. The population is eight grade students in one of Junior Secondary School that is located in Bandung, Indonesia. The sample consist of 25 students that chosen based on purposive sampling technique. The data is obtained through Creativity Product Analysis Matrix (CPAM). There are three creativity dimension that used in this study which are resolution, elaboration and novelty dimension. Students’ creativity is obtained as much 76% which categorized as good. Based on the result, STEM project-based learning give the good impact on students' creativity. STEM project-based learning can be used as alternative teaching strategies in Junior Secondary School.
Algorithm of Rational Planning and Resource Distribution in the Task of Preparing the Aircraft Group for Use
Authors: Buryak Yu. I. , Screennikov A. A.
Published: May 2019

The work is devoted to solving the problem of justifying the rational composition of a team of specialists who provide preparing for a group of aircraft for a given time. To substantiate the optimal composition of the team, it is necessary to solve the problem of scheduling work on a group of aircraft with different composition of specialists. This, in turn, requires consideration of the huge number of options for streamlining work performed on each aircraft, and options for organizing the sequence of maintenance by one specialist of several aircraft. Finding solutions using combinatorial optimization requires an unacceptably high computational cost. The article proposes an approach for finding not the optimal, but some rational admissible solution, which is not much worse than the optimal one, but its definition does not require large computational resources. An algorithm for rational work scheduling based on discrete-event modeling is proposed. Planning is carried out sequentially in time. When planning the sequence of work, it was suggested first of all to put the work with the maximum duration possible. The developed algorithm is software implemented, which allowed to investigate some properties of the solutions obtained. Examples of calculating the schedule of work on a group of aircraft with a different composition of the team of specialists are given. The problem of justification of rational structure of the team is solved by rational planning algorithm works by sequentially increasing the number of specialists. An example of substantiating the rational composition of a team of specialists performing preparing of a group of eight aircraft, each of which performs five types of work, is given and analyzed in details. The high speed of the calculations for the rational planning of work by a given team allowed to consider all possible options for the team (tens of thousands of options) and substantiate such an option that the number of specialists in the team would be minimal, but they would ensure the preparation of aircraft for a given time. Low requirements for computing resources allow solving problems with a sufficiently large number of types of work performed on each aircraft of the group.
RISK FACTORS FOR DEVELOPING CHILDREN AND YOUNG PEOPLE DEPENDENT ON SUBSTANCE USE BEHAVIOR
Authors: Liakh Tetiana , Spirina Tetiana , Popova Alona
Published: May 2019

A pivotal feature of the vulnerability of families, in which there are persons who use psychoactive substances, is that such persons develop dependent behavior. It leads to serious violations of physical and mental health, loss of social contacts, etc. The roots of the addictive mechanisms of any addition should be sought in the childhood, in the peculiarities of upbringing, in the behavior of parents or one of them. The purpose of this article is to determine and substantiate the risk factors for the formation of addictive behavior in children and young people from the use of psychoactive substances. The results of the expert survey authors have joined a group of risk factors for developing children and young dependent behavior of the use of a couple of groups of "biological factors", "psychological factors", "family", "impact of peers", "impact of educational institution", "social influence" as well as proposed protective mechanisms for each of the groups. The study brings results of our own research in this area. A well-founded theory served as the basis for collecting data both at the theoretical level and at the level of processing the results of expert interviews. Determined by expert interviews risk factors for developing children and young people dependent on substance use behavior made it possible to develop a model needs assessment and decision on the future of social work with people who use psychoactive substances and their families.
A NEW DIGITAL ART GAME: THE ART OF THE FUTURE
Authors: Gintere Ieva
Published: May 2019

The task of this study is to create an innovative digital art game of contemporary aesthetics on the basis of research. Research implies the analysis of digital art games and the historical background of their aesthetics, as well as their classification following the stylistic trends. Digital games have a great potential to integrate people into fields that would otherwise not meet their interest. The new game would develop the creative skills of players and teach them the current trends in digital art. The game would project the inheritance of art from the age of modernism into the digital world by teaching the player to recognize it (for instance, pixel aesthetics is a successor to cubism and constructivism). The new game will let its user play around with the trends in digital art such as vaporwave, glitch and others, and to create new ones. Thus, it would deal with the problem of knowledge cache and cultural segregation that characterizes modern art: being an esoteric subject to a great extent, it is difficult to access a large segment of the public. The aim of this study is to raise the interest of a wide-ranging public for contemporary art and to point out the newest creative tendencies in art. The paper presents an overview of digital art games, introduces a novel term, vaporwave, that has not been registered in the art game discourse so far, and offers an updated definition of the art game. The Design Science Research method is used in order to cross-cut such remote fields as the general public and the arthouse world, codes of modern art and the taste of the general public.
THE DIGITAL GENDER DIVIDE: AN OVERVIEW
Authors: Marzano Gilberto , Lubkina Velta
Published: May 2019

It has been observed that women, especially in developing countries, have significantly lower technology participation rates than men. This is generally considered to be the result of socio-cultural attitudes related to the expected role of women in society. The consequence is the low percentage of women working in the high-tech industry. However, nowadays, women make ample use of internet technology and access social media just as much as men.This article will explore the issue of the digital gender divide, focusing on which factors can impede and/or facilitate access to and use of digital technologies.  It represents the preliminary results of an ongoing research conducted within a bilateral project entitled “Gender aspects of digital readiness and development of human capital” that involves the Latgalian region in Latvia and the Ternopil region in Ukraine, two regions that share similar socio-economic problems.The aim of the research is to increase the level of women’s inclusion in the labor market of the future, which itappears will be increasingly dominated by digital technologies. From this perspective, reducing the digital divide is crucial, but alternative forms of digital education will need to be introducedin order to facilitate the acquisition of digital competences.
Языковая ситуация и языковая политика в России (ревизия категорий и практик)
Authors: Тишков Валерий
Published: May 2019

В статье рассматривается практика категоризации и процедур в сфере языковых ситуаций и языковой политики в России в сравнительном аспекте. В центре анализа взаимосвязи “язык и этничность”, “язык и политика”, особенно в практике переписей населения, и их интерпретации. Предлагается пересмотр категорий “родной язык”, “материнский язык”, “национальный язык” в пользу ситуативного и множественного подходов, которые учитывают факторы рационального выбора, языкового рынка, структурных предписаний, языкового репертуара в культурно-сложных обществах, а также историческую динамику языковых процессов. Автор обосновывает отсутствие жесткой связи между языком и этничностью и ставит вопрос обеспечения прав языковых сообществ, поддержки языков как самостоятельных ценностей в культуре человеческих коммуникаций. В сфере языковой политики рассматриваются роль языковых проблем в современном нациестроительстве, соотношение государственного (национального) языка и этнических (миноритарных) языков в общественной жизни таких стран, как Российская Федерация.
Estrategia de comprensión lectora: una propuesta para la lectura de hipertextos.
Authors: García-Gracía Miguel Ángel , Arévalo-Duarte Mayra Alejandra , Hernández-Suárez César Augusto
Published: May 2019

The literature review done for conducting this study has to do with the text and user`s variable that has to do with the conclusive results in the construction of meaning and the proposal of guidelines or strategic principles that help to improve the hypertextual understanding. where primary sources of information were identified as constituent elements of the theoretical framework, the foundation of the system of categories and the instrument designed for the organization and systematization of the data. The results are product of the analysis process of these sources and respond to each of the proposed objectives. Finally, the proposal consists of strategic principles that can guide the hypertextual reading, constructed under the articulation of the theoretical constructs and the results of analysis.
The Australian Mail Handling Scene
Authors: Moorhead Simon
Published: May 2019

Two historic papers from 1966 detailing the mail handling scene in Australia and the development of the state-of-the-art Sydney Mail Exchange.
Comparative efficacy between ketamine, memantine, riluzole and d-cycloserine in patients diagnosed with drug resistant depression: a meta-analysis
Authors: Darji Nishita H. , Rana Devang A. , Malhotra Supriya D.
Published: May 2019

Background: Glutamate modulators are having immense potential and are newer entities for treating drug resistant depression. The objectives were to generate statistical evidence on basis of existing data of ketamine, memantine, riluzole and d-cycloserine in resistant depression.Methods: A total of 14 RCTs following PRISMA guidelines and matching inclusion and exclusion criteria were collected of ketamine (5), memantine (3), riluzole (2) and d-cycloserine (4) vs placebo in drug resistant depression. Only RCTs with primary diagnosis of drug resistant depression (Previously on two standard antidepressant therapy) were included. Studies with treatment response rate, 50% reduction in total score of the depression rating scale-Montgomery-Åsberg Depression Rating Scale or the Hamilton Depression Rating Scale or Beck Depression Inventory was chosen as clinical outcome measure. RevMan 5.3 software was used for the analysis.Results: In ketamine group using random effect model SMD was 2.122 (95% CI 0.659-3.584). P-value was statistically significant (random effect p <0.005 and in fixed effect <0.001). In memantine group, using random effect model -0.963 was SMD and (95% CI -1.958-0.0324). P-value was <0.001, significant in fixed effect. In riluzole group, SMD was -0.564 with (95% CI -3.927-2.799) in random effect. P-value was 0.741. In d-cycloserine group SMD was 0.316 with (95% CI -1.252-1.885) in random effect. P-value was 0.690.Conclusions: Ketamine showed best efficacy followed by memantine. Riluzole and DCS as such have no efficacy although its acts by same glutamate pathway. More molecular based research is required in use of glutamate modulators in resistant depression.
Trends of human influenza infection in Chhattisgarh: a retrospective observational study
Authors: Sharma Raj , Bharti Rupendra K. , Sharma Sanat , Jaiswal Mahendra K.
Published: May 2019

Background: Human influenza virus was recognized as a pandemic in 2009 by the World Health Organization (WHO). Since then many newer incidences was recognized in India, but there was no sufficient data from all state of India. This study will provide data from the Chhattisgarh state of India.Methods: It was a retrospective observational study from December 2015 to November 2017. All patient samples with suspected influenza infection were collected and analysed by Real-time reverse polymerase chain reaction (RT-PCR).Results: 341 patients’ sample was collected and analysed; among these samples, 07.9% of patients have all three serotype of influenza positive. Raipur district has the highest incidence of influenza A followed by Durg and Raigarh district of Chhattisgarh. There was no significant difference between male and female who was affected by the influenza virus.Conclusions: The incidence of Human influenza virus is lesser in Chhattisgarh as compare to the average states of India and the state capital has a higher rate of sample collection as well as positive influenza infection.
A study to evaluate the skeletal muscle relaxant property of Pregabalin and Gabapentin in albino rats
Authors: Naidu Sushma V. , Rani Vibha
Published: May 2019

Background: Skeletal muscle relaxants are the drugs which reduce unwanted spasm without interfering with consciousness and voluntary movements. The centrally acting muscle relaxants like Diazepam, is known to be GABA mimetics and other antiepileptics like Gabapentin and Pregabalin also act through the release of GABA. This study is done to investigate skeletal muscle relaxant property of these drugs in comparison to Diazepam.Methods: T Models used in the experiment are Grip Strength Test, Rota Rod Method, Beam Walk Test, Photoactometer Test. Animals were divided into 6 groups of 6 rats each: Group 1: Control group treated with normal saline (0.1 ml/10gm), Group 2: Standard-15mg/kg of Diazepam, Group 3:T1-60 mg/kg of Gabapentin, Group 4:T2-10 mg/kg of Pregabalin, Group 5:T3-60 mg/kg of Gabapentin+Diazepam, Group 6:T4- 10 mg/kg of Pregabalin+Diazepam. Mean and standard deviation was calculated for each group. One way ANOVA was used for multiple group comparisons followed by post hoc Tukey’s test for statistical significance between the groups.Results: Treatment with the above test drugs produced significant muscle relaxation and caused decreased fall off, sliding time, increase climbing time and decreased locomotor activity in all models indicating motor incoordination. The results obtained from both standard and test groups showed a highly significant difference in muscle relaxation when compared with the control group.Conclusions: The test drugs showed skeletal muscle relaxant property in rats comparable to Diazepam. In view of these results, it can open a new avenue for these drugs to be used as skeletal muscle relaxants after conducting clinical trials.
Knowledge, attitude and practice of pharmacovigilance towards adverse drug reactions reporting among health care professionals (nurses) in a tertiary care teaching hospital in Eastern India: an observational study
Authors: Misra Debasish , Das Smita , Behera Rasmirekha , Rath Karmajeet , Mishra Swati , Mishra Sudhansu Sekhar
Published: May 2019

Background: Nursing staffs spend most time in patient care and are bedside caregivers. To expect voluntary reporting of adverse reactions, it is essential that they possess proper knowledge, right attitude and practice reporting. Therefore, the present study was aimed to assess the Knowledge, Attitude and Practice of Pharmacovigilance towards ADRs reporting.Methods: A prospective, cross sectional, observational, questionnaire-based survey was conducted among nurses in a tertiary care teaching hospital in Eastern India. Questionnaire containing 15 questions was used to assess knowledge, attitude and practice. The questionnaire was administered to 150 nurses. Analysis of data was done using statistical software..Results: The response rate in our study was 86.67%. Nurses have good knowledge of pharmacovigilance and adverse reaction. However, only 10% have reported an adverse reaction in our study. This shows that in spite of having a good knowledge of reporting, nurses have poor attitude, which is reflected by a low reporting rate. Nurses opined that taking patient care is of prime importance than report an adverse reaction. This corroborates the low reporting rate in our set up.Conclusions: Majority of nurses have good knowledge on pharmacovigilance and adverse drug reaction. The concern remains on the low reporting rate. Continuous training programmes, and reminders likely to enhance the voluntary reporting from the nursing staffs.
USG guided pigtail catheter placement for drainage of liver abscess as a minimally invasive procedure
Authors: Prasanth Gurijala , Prasad Ballapalli Hari
Published: May 2019

Background: The objective of the study was to evaluate the advantages of USG guided pigtail catheter placement for drainage of liver abscess as a minimally invasive procedure.Methods: This is a retrospective study conducted in Kamineni Institute of Medical Sciences, Narketpally, Nalgonda, April 2017 to August 2017. It included 45 patients who were diagnosed with solitary liquefied liver abscess. The effectiveness of drainage was determined by doing serial USG scans.Results: Age group varied from 27 to 52 years. Out of 45 patients 41 were men and 4 were women. The male to female ratio was 10:1. All the patients underwent USG guided pigtail catheter insertion for solitary liver abscess. Average hospital stay varied from 2–3 days. No complications were observed during the procedure.Conclusions: This study concludes that drainage of solitary liver abscess by USG guided pigtail placement as a minimally invasive procedure was good in clinically improving the patient’s general condition & decreasing the size of abscess cavity.
Evaluation of the lipid parameters in chronic heart failure patients and their correlation with body mass index
Authors: Sane Rohit , Amin Gurudatta , Dongre Snehal , Mandole Rahul
Published: May 2019

Background: Increased body mass index (BMI) is associated with dyslipidemia, but relevant data in patients with cardiac morbidity is scarce. This study assessed lipid parameters in chronic heart failure (CHF) patients and their statistical correlation with BMI.Methods: The retrospective study utilized data of CHF patients who visited Madhavbaug clinics in India between July-December 2018. Serum lipid profile noted were total cholesterol (TC), triglycerides (TG), low-density lipoproteins (LDL), high-density lipoproteins (HDL) and very low-density lipoproteins (VLDL). Patients were classified based on BMI (normal, overweight, obese) and their mean lipid parameters were compared.Results: Out of 147 patients, 74.15% were males with mean age 59.15±10.28 years and mean BMI 26.69±4.97 kg/m2. 56 patients had normal BMI, 60 were overweight and 30 were obese. Mean TC, TG and LDL levels in the normal-BMI group were significantly lower than that in overweight and obese groups (p<0.05). Mean HDL and VLDL were found to be higher in overweight group as compared to that in normal-BMI and obese group (p<0.05). Weak positive correlations were found between BMI and TC (R=0.09, p>0.05), BMI and TG (R=0.07, p>0.05), BMI and LDL (R=0.09, p>0.05) as well as BMI and VLDL (R=0.02, p>0.05). There was inverse correlation seen between BMI and HDL (R=-0.12, p>0.05).Conclusions: Increase in BMI was associated with dyslipidemia in CHF patients. There was positive correlation of BMI with LDL, TG, TC as well as VLDL while there was negative correlation between BMI and HDL levels. Obesity may increase the dyslipidemia risk in CHF patients which may affect their prognosis.
Association of high-density lipoprotein and myocardial infarction: a cross sectional study
Authors: Thirupathi Siraveni , P. Chinnaiyan , Chandrababu Sujeetha
Published: May 2019

Background: There is substantial evidence illustrating a negative relationship between High Density Lipoprotein Cholesterol (HDL-C) to Coronary Artery Disease (CAD) progression. HDL concept can be put forward as a new concept in the field of cardiovascular research. The objective of this study was to carry out to observe the status of serum HDL-C level in Coronary Artery Disease patients and the impact of the level in them.Methods: It was a hospital based cross sectional observational study among 60 patients of acute myocardial infarction (MI) who were admitted in Medical intensive care unit. High density lipoprotein cholesterol (HDL-C) was determined using standard methods.Results: The study showed that 52 (86.7%) of study subjects had abnormal HDL-C level and 39 (65%) of subjects had abnormal CRP level. There is a negative correlation between HDL and other biochemical variables like LDL, LDL/HDL and CRP, i.e. as HDL decreases all the variables increase which is statistically significant. Majority of patients 52 (86.7%) with MI had abnormal HDL-C level which was not statistically significant.Conclusions: Numerous studies showing evidence that high levels of HDL-Cholesterol associated with a lower risk of Coronary heart disease. This study showed that there is a low HDL-C level among coronary artery disease patient. The relationship between HDL and CAD proved to be an inverse one which caters the need to concentrate further on HDL.
Antihypertension medication adherence and associated factors at tertiary care hospital, Gujarat, India
Authors: Goswami Dinkar
Published: May 2019

Background: According to world health organization (WHO) describes poor adherence as the identical cause of uncontrolled blood pressure and estimates that 50-70% of people do not take their antihypertensive medication as prescribed. The objectives of this study were to investigate the adherence and persistence of antihypertensive drugs in Indian rural population as well as monitoring adverse drug reactions and its relation to compliance.Methods: This cross-sectional study conducted among 300 hypertensive patients taking treatment at tertiary care hospital in Gujarat, India. Structured questionnaires consisting of open and closed ended questions on the antihypertensive drug adherence were distributed to patients for those found on the study area at time of data collection and the left-over pills of individual patient were counted to strengthen the consistency of the research.Results: Prevalence of non-adherence found in 24.3% participants. Present study found statistically significant association between socio-demographic factors (age, religion, marital status, occupation, substance abuse, education and family history of HT) with treatment adherence of hypertension among study participants. The other factor associated to non-adherence was therapy factor 32.9% (P=0.001) from the total non-adherence, in this case patients were supposed to unwanted effect of the drug and they were not able to take the medication.Conclusions: The main possible reasons for non-adherence were ‘refuse to take regular treatment’,‘cost of treatment’, ‘poor patient-doctor relation’, ‘unwanted side effect of drugs’ and other factors like age, marital status, occupation, education level, family H/O, substance abuse and religion are also playing supporting role to develop non-adherence to treatment.
Comparison of model for end-stage liver disease-Na score and model for end-stage liver disease score in predicting in-hospital mortality in patients with end stage liver disease: an observational study
Authors: Mukherjee Tirthankar , Nataraju Kamalesh Tagadur , Rakesh B. M. , Dandothi Soumya Dattanagowda
Published: May 2019

Background: Model for end-stage liver disease (MELD) score was originally developed to predict mortality after trans jugular intrahepatic portosystemic shunt. Hyponatremia is the most common electrolyte abnormality in end stage liver disease (ESLD). Incorporating serum sodium into MELD score increases its predictive accuracy.Methods: This is an observational study conducted on 50 patients of ESLD admitted from October 2012 to September 2014. Study population was divided into survivor and non-survivor groups. MELD score and MELD-Na score was calculated and compared between the groups.Results: Out of 50 participants, 20 (40%) died in the hospital due to cirrhosis related complications.  The average age was 44.7±12.040 years in the survivor group and 54.1±9.910 years in the non-survivor group. The mean MELD score and MELD-Na score was found to be higher in non-survivors group (28.5 and 30.5) compared to survivors group (22.03 and 25.67) which was statistically very significant. Majority of the patients in survivor group had MELD score between 10-19 (43.3%) and 30-39 (36.7%). In the non-survivor group majority of patients had score of more than 20 (80%). MELD-Na score has better sensitivity (90%) compared to MELD score (80%) at a cut off value above 22. However, MELD score has better specificity (60%) compared to MELD-Na score (43.3%) at the same cut off value.Conclusions: MELD-Na score was higher in non-survivor group with good predictability for in-hospital mortality and there was good correlation between both the scores in terms of degree of agreement and MELD-Na score was more sensitive compared to MELD score.