bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of an arteriovenous fistula stenosis prevention program in patients receiving hemodialysis
Authors: Lee Haegyeong , Baek Gyuli , Lee Eunju
Published: August 2023

Objectives: To increase the efficiency of hemodialysis, an appropriate vascular pathway must be created, and its function must be maintained. This study aimed to identify the effects of an arteriovenous fistula (AVF) stenosis prevention program on upper muscular strength, blood flow, physiological indexes, and self-efficacy among patients receiving hemodialysis.Methods: The participants were patients receiving hemodialysis at Keimyung University Dongsan Medical Center in Daegu, Republic of Korea. They were divided into experimental and control groups based on the day of the week they received hemodialysis at the outpatient department and included 25 participants each. The study was conducted for 8 weeks.Results: The AVF stenosis prevention program was effective in improving upper extremity muscle strength (F=15.23, p<0.001) and blood flow rate (F=36.00, p<0.001). As a result of the program, the phosphorus index level, which is a physiological indicator in hemodialysis patients, decreased (F=8.64, p<0.001). Encouragement and support through text messages and practice lists also resulted in an increase in self-efficacy (F=18.62, p<0.001).Conclusion: The AVF stenosis prevention program in this study resulted in an increase in upper extremity muscle strength through grip strength exercises and was effective in preventing AVF stenosis by increasing the blood flow rate.
A review of low-frequency latex harvesting systems that lessen the tapper shortage problem of the smallholders' natural rubber production
Authors: Zaw Zar Ni
Published: August 2023

Smallholders' rubber production is encountering problems of skilled tapper shortage and high production costs resulting from increased worker wages and the substantial growth of new mature areas. Low-frequency latex harvesting system (LFLHS) effectively improves tapper productivity with long-term optimum yield by reducing the tapper requirement. LFLHS reduces tapper requirement by 33% to 67% of the conventional harvesting systems. Under the d3 (tapping every three days) frequency harvesting system, a tapper is assigned to cover three tasks, and his productivity is at least 30% higher than that of the d2 (alternative daily) frequency harvesting system. The cumulative yield of LFLHS is comparable to that of d2 frequency. It is economically profitable when the cumulative yield of LFLHS reaches 90% of the d2 frequency tapping as a break-even yield. Its low number of tapper requirement and high productivity saves tapping cost. 20% to 55% of tapping cost can be reduced by shifting the harvesting frequency from d2 to d3. The virgin bark of basal panels could be tapped at least four to ten years more than conventional tapping systems. The low bark consumption allows sufficient time for the regeneration of bark tissues resulting in a potentially higher yield from the renewed bark. Thus, sustainable economic yield is achievable for a productive lifespan of 30 to 35 years from the LFLHS. These advantages of LFLHS contribute to reducing the tapper requirement and cost of production, ensuring increased profits and a longer economic lifespan of rubber production.Keywords: Latex harvesting system, Tapper requirement, Tapper productivity, Tapping cost
El sistema educativo japonés: sus características y la formación escolar de la población
Authors: Ramírez Bonilla Juan José
Published: August 2023

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El Medio Oriente en el nuevo orden internacional
Authors: López Villicaña Román
Published: August 2023

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Norton Ginsburg, Bruce Koppel y T.G. Mcgee. The extended Metropolis, Settlement Transition in Asia. Honolulu: University of Hawaii Press, 1991, 339 pp.
Authors: Connelly Marisela
Published: August 2023

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Prevalence and Risk Factors of Helicobacter Pylori Infection in Asymptomatic Sudanese Population: A Cross-sectional Study
Authors: Abozaid Lobaina Mohammed
Published: August 2023

Background: Helicobacter pylori infections are a global problem, and constitute a known cause of gastrointestinal diseases such as gastritis, peptic ulcers, and gastric malignancies; they are also implicated in extra intestinal diseases, such as chronic urticarial and peripheral arterial disease. This study aims to determine the prevalence of Helicobacter pylori infections in asymptomatic individuals, and to estimate the risk factors of the infection.

Methods: A cross-sectional study was conducted at Kassala Military Hospital in Sudan. A convenience sample of healthy individuals was used; 237 people were checked for eligibility. The individuals who were included to participate in the study consisted of healthy individuals, hospital staff, blood donors, and females arriving to receive antenatal care. A questionnaire was used to record the socio-demographics of the participants. Helicobacter pylori antibodies were detected in their blood by a rapid chromatographic immunoassay.

Results: Of the 207 participants, 92 (44.4%) were male and 115 (55.6%) were female. The prevalence of the Helicobacter pylori infection was 48.1%, and was significantly associated with the water source (p = 0.02) of the participant and whether they shared a bed with their siblings during childhood (p = 0.016). There was no association found between the Helicobacter pylori infection and sanitation methods, gender, employment status, number of rooms in a dwelling, or level of education.

Conclusion: The prevalence of the Helicobacter pylori infection was 48.1%, and the infection was significantly associated with the source of water and childhood sleeping arrangements.
The relative effect of trade and tax reformson import tax revenues in Ghana
Authors: Brafu-Insaidoo William Gabriel , Obeng Camara Kwasi , Ewusie Ewura Adwoa
Published: August 2023

This study examines the relative effects of alternative import policy reform features and value added tax on import tax revenues in Ghana. To achieve this objective, the study first estimates the effect of alternative import policy features and VAT on import tax changes. The estimated coefficients are then applied to the observed values of each respective import policy feature and VAT to obtain the contribution of each policy feature to change in import tax revenue. The study concludes that Ghana has made some revenue gains by reducing the average official duty rate and imposing VAT rate on imports, and that revenue gains have outstripped revenue losses from the reforms. It is subsequently suggested that the government should maintain the current strategy of replacing tariffs with a type of consumption tax.
Humic acid as a growth booster: Evaluating its synergistic influence on three red radish varieties
Authors: Hussain Kashif , Kiran Mehwish , Haq Fazal , Waseem Kashif , Nadeem Muhammad Amjad , Ullah Ghazanfar , Farid Arshad , Aziz Tariq
Published: August 2023

The study focused on investigating the effects of varying levels of HA (HA1 = 0, HA2 = 25, HA3 = 50, HA4 = 75, and HA5 = 100) on Red Dragon, Red Prince, and Red Meat varieties of red radish. This analysis aimed to unravel the relationship between different levels of HA and their impact on the growth and productivity of red radish genotypes. The findings revealed that the Red Prince genotype attained the utmost plant height of 24.00 cm, an average of 7.50 leaves per plant, a leaf area of 23.11 cm2, a canopy cover of 26.76%, a leaf chlorophyll content of 54.60%, a leaf fresh weight of 41.16 g, a leaf dry weight of 8.20 g, a root length measuring 9.73 cm, a root diameter of 3.19 mm, a root fresh weight of 27.60 g, a root dry weight of 6.75 g, and a remarkable total yield of 17.93 tons per hectare. The implications of this study are poised to benefit farmers within the Dera Ismail Khan Region, specifically in the plain areas of Pakistan, by promoting the cultivation of the Red Prince variety.
Building Intercultural Spaces through Co-Creation: Insideness in Shared Living Spaces
Authors: Liao Christine , Iezaki Moe
Published: August 2023

We explored the role of art in facilitating intercultural communication through a project in which undergraduate students from the United States and Japan co-created a digital collage of shared living spaces. Through the creation of personal dioramas and a collaborative collage, students shared personal stories and objects that were meaningful to their identity formation. Our research found that incorporating personal memories and cultural objects into art-making was an effective way of evoking a sense of insideness with a place and bridging cultural differences. The collage was a learning space where students negotiated differences and worked together to create a more inclusive place through vicarious insideness. This study highlights the potential for using art to facilitate intercultural communication and engage a sense of insideness in unfamiliar places among individuals from different cultures.
Education as Affective: Making Visual Journals During the Covid-19 Pandemic
Authors: Kaplan Heather
Published: August 2023

This paper considers the pedagogical and research potential of visual journals to uncover the affective in education. Spurred by the sudden instructional shift from in-person learning to asynchronous instruction, visual journals were utilized in order to understand student experience of the pandemic and to consider whether education, as usual, was possible after significant affective and material societal shifts happening at the early stages of the pandemic. Massumi’s (2015) notion of affective threat is utilized along with affect theory in order to uncover the affective realm of education during the pandemic and, therefore the latent affective realm of education.
Art and visual intervention strategies to resist racism and racial stereotypes
Authors: Shin Ryan , Lee Oksun , Koo Ahran , Hsieh Kevin , Gu Min
Published: August 2023

In our article, we share five teaching strategies to address and confront racism, racial bias, and stereotypes. Echoing contemporary artists who provide excellent visual interventions against racism and racial violence, we offer artistic and visual intervention strategies designed for art classrooms and community settings. Our strategies include visual intervention, anti-racist gaze, counter-narrative and storytelling, cultural and ethnic identity celebration, and coalition building. We believe that these strategies advance racial dialogues in schools, providing students of color with opportunities and tools for their stories to be heard. Facing unprecedented violence and multi-layered racial problems in our society, our strategies grounded in the power of artistic intervention and activism will offer a valuable tool to engage students with the practice of anti-racism.@font-face{font-family:"Cambria Math";panose-1:2 4 5 3 5 4 6 3 2 4;mso-font-charset:0;mso-generic-font-family:roman;mso-font-pitch:variable;mso-font-signature:-536870145 1107305727 0 0 415 0;}@font-face{font-family:Calibri;panose-1:2 15 5 2 2 2 4 3 2 4;mso-font-charset:0;mso-generic-font-family:swiss;mso-font-pitch:variable;mso-font-signature:-536859905 -1073732485 9 0 511 0;}p.MsoNormal, li.MsoNormal, div.MsoNormal{mso-style-unhide:no;mso-style-qformat:yes;mso-style-parent:"";margin:0in;line-height:115%;mso-pagination:widow-orphan;font-size:11.0pt;font-family:"Arial",sans-serif;mso-fareast-font-family:Arial;mso-ansi-language:EN;}.MsoChpDefault{mso-style-type:export-only;mso-default-props:yes;font-size:11.0pt;mso-ansi-font-size:11.0pt;mso-bidi-font-size:11.0pt;font-family:"Arial",sans-serif;mso-ascii-font-family:Arial;mso-fareast-font-family:Arial;mso-hansi-font-family:Arial;mso-bidi-font-family:Arial;mso-ansi-language:EN;}.MsoPapDefault{mso-style-type:export-only;line-height:115%;}div.WordSection1{page:WordSection1;}
From a Native Worldview: The Concept of the Traditional in Contemporary Native American Art Practices
Authors: Ballangee Morris Christine , Staikidis Kryssi
Published: August 2023

This article explores tradition and ceremony in contemporary Native American art. Indigenous scholars and artists use traditional knowledge to navigate contemporary contexts. Shared perspectives challenge binaries, problematic due to Indigenous peoples’ relationship to colonization. The study used Indigenous research incorporating critical theory (Grande, 2015), decolonizing and Indigenous Research Methodologies (Tuhiwai Smith, 2021), and Indigenous research rooted in relationality (Wilson, 2008). We examined traditional meanings for Native Americans in contemporary art through reflection and dialogue. Research components included a historical overview, an examination of literature, interviews, and oral histories. Transforming Our Practices: Indigenous Art, Pedagogies, and Philosophies (Ballengee Morris & Staikidis, 2017) was consulted, in which Indigenous artists described artmaking as regenerating collective memory. Suggestions were made to reconsider traditions in Native American art to promote new outcomes in visual arts research and pedagogy informed by Indigenous epistemologies.
Social Movements in Europe, from the Past to the Present
Authors: Silva Célia Taborda
Published: August 2023

Over time, the concept of social movement has evolved as society has changed, but has always implied collective action in the public space. The form of social contestation has changed, according to the conjuncture of each historical period. In 18th century, the transition from the Old Regime to Liberalism provoked movements considered by some authors as “primitive” or “premodern”, as they were spontaneous, sporadic and depoliticized. Industrial society of the 19th century gave rise to the labor movement and trade unionism, which from then on organized the social movements. In the 20th century there were changes and innovation in the collective way of acting, there was the emergence of a series of social movements that differ from the traditional in terms of the objectives and actors involved, such as the pacifist, ecologist, feminist movements, acting on the fringes of parties and unions. The 21st century has witnessed a set of movements that begin on social networks, such as Generation Scratch, Outraged, Occupy Wall Street, Screw the Troika, and quickly outgrow local scales to become global. Through the use of a theoretical and conceptual framework derived from the theories of social movements and taking into account the current transformation of collective action that has been witnessed in the 21st century, we intend to verify if we are facing a new social phenomenon or another phase of “repertoire” change.
A New Pathway towards Retirement Preparation: Integration of Holistic Life Planning
Authors: Ibrahim Dayang Kartini Abang , Wahat Nor Wahiza Abdul
Published: August 2023

This is a concept paper to review the needs of holistic life planning as a new pathway towards retirement preparation. It is based on the review of literature on the importance of this knowledge to fulfil individual successful planning and preparation for retirement. It includes the review on a planning process theory by Friedman and Scholnick (1997) which provides the basis for generation of retirement preparation. Meanwhile Hansen’s Integrative Live Planning (ILP) theory is embedded within the theoretical framework to help better understanding on the domains of planning and preparation for retirement. The purpose is to develop a theoretical model for measuring employees’ retirement preparation in government organizations. The primary problem in retirement preparation is the lack of theory to show the development of retirement preparation process. Although prior research has theories explained on retirement thoughts, behaviors, attitudes or goals undertaken to fulfill the retirement preparation, none of it measures applied in the studies were established to directly test the theories according to the process and development of retirement. According to the process theory, individuals acquire an understanding of the problem, goals will be set in making a decision to start preparing and finally behaviors is considered necessary to fulfil the goals (Noone et al., 2009). This raises intriguing questions: What factors influence retirement preparation? Which stages in retirement planning and preparation require intervention and support? (Noone et al., 2009) Which domain in life is significant to retirement preparation? The theory is discussed throughout the paper in the context of the needs of retirement preparation. This paper would be useful for policy makers, practitioners and employees in considering their own retirement preparation for future well-being.
The Administration of Corporate Social Responsibility in the District Regulation in Indonesia
Authors: Nd Mukti Fajar
Published: August 2023

In Indonesia, Corporate Social Responsibility (CSR) is corporate activity that is regulated by the law. By means of the Investment Law No.25 year of 2007 and the Limited Liability Company Act No. 40 year of 2007, it is regulated that every company in Indonesia is obliged to implement CSR. However, these regulations are not set technically; therefore, some local governments have made guidelines for the implementation of CSR through the District Regulations. The problems of this study are: (1) how is the CSR regulation model in the District Regulation? (2) What are the company’s attitude and the company’s request towards the CSR regulation in the District? This study uses normative law research method that examines the provisions of the law, as well as empirical legal research method that used to observe the behavior and the attitude of the government and corporate actors. This research took place in several provinces in Indonesia.The results of this research are: First, the CSR regulation in regional area is formulated based on local government authorities. The provisions of these district regulations are customized to the interests of each region, although it still normatively refers to the standard legislation. Second: The Company’s attitudes prefer the self-regulated regulations arranged by their respective companies. Additionally, the setting of CSR can make the arrangement of CSR activities in accordance with the District Government program; as a result, it can speed up the community development.
Information About Ourselves from Ourselves: Young Users of Wearable Technologies in Secondary School
Authors: Matteucci Ivana
Published: August 2023

Several researchers have recognized the value of self-tracking technologies used to personally obtain data about ourselves. The aim of the present study was to assess the barriers associated with the “technologies of existence”, so-called wearables, including lack of knowledge of these devices, lack of information on their correct use, as well as difficulties regarding data integration and interpretation. To help to overcome these barriers we investigated a project involving two self-tracking activities in an Italian secondary school, performing a quantitative and qualitative analysis of the students using these technologies for educational purposes. Thanks to the project and its contextualized practical and theoretical activities, students were able to become “enhanced users” in terms of their knowledge, autonomy and awareness as regards wearable technologies. Our findings regarding the application of wearable technologies in a scholastic setting may also be step forward in addressing a well-known common pitfall of self-tracking: insufficient scientific rigor. Our quantitative and qualitative analysis showed how the use of wearable devices in educational settings had a range of beneficial effects, above all, eliciting satisfaction among students, but also yielding positive outcomes regarding the acquisition of scientific knowledge perceived both in terms of device applications and data interpretation. In conclusion, our findings may have broad implications in the future design and development of wearable technologies.
Big Data and the Demand for Court and Legal Services
Authors: Pérez Carmen Vargas , Figueroa Juan Luis Peñaloza
Published: August 2023

Law and Economics literature has dealt with the factors determining the demand side of justice for more than 40 years. Both theorists of economic analysis and applied researchers have focused on the different variables that influence demand, such as direct and indirect costs, the chances of winning, the chances to settle out of court and delay, among others, which in turn may be affected by the judges, lawyers and parties incentives. Many of these variables cannot be directly observed by the ordinary citizen. In this paper, we contribute to the Law and Economics literature by showing that Big Data must be considered a new way to approach demand for court and legal services as it introduces new criteria to take into account and a new way to make the decision of whether or not to proceed to trial.
Diversity and uniqueness of Family business in the North of Portugal
Authors: Marques Ana Paula
Published: August 2023

Family businesses are the most omnipresent form of business organisations at the international and national levels. In Portugal, family firms account for more than 70% of all businesses, contributing with 50% in employment creation. Yet, most of the existing literature does not converge in a consensual and operative definition of what are core elements which distinguish family business from non-family business. Therefore, it is crucial to extend our knowledge on important family business topics due to the broadness, diversity, uniqueness and growth potential of family business in the whole world. In this sense, the ongoing project “Roadmap for Portuguese Family Businesses” (NORTE2020/FEDER) is focused on providing a better understanding and assessment of the impact of family businesses in the North of Portugal on the local, national and international economies. This research addresses a major problem that has been identified in Europe and consists in the lack of institutional visibility, particularly of accurate and up-to-date statistics in this sector. This paper begins by identifying some of the interesting research questions that emerge from examining the business family portraits. Then, based on some preliminary empirical findings gathered from ongoing research, first of all, we intend to identify interesting profiles of family business by mobilising some socioeconomic variables; and secondly, to point out major challenges faced by Portuguese family business.
Introduction of a Systemic Innovation Management Model for Facilitating Process Innovation
Authors: Schoorl Marianne , Kievit Pieter , Oomes Jeanette , Bartels Piet CM
Published: August 2023

Within health care projects for change and innovation, professionals should ambitiously cooperate in order to yield a creative multidisciplinary mindset for guaranteed innovative output. Failure of innovation projects is amongst others due to deterioration and insufficient focus on relational aspects. Aim; an innovative management tool for facilitating process innovation is launched. Methods; Systemic innovation (SI) is a social network management model, subsidiary to actual management models for quality improvement and innovation. The SI management model yields essential tools for stimulation of communication in multidisciplinary teams in order to shape alternative mindsets. Results; The key domains of SI representing socio-dynamics, value of arguments and flexibility for change concern topics for assessment of behavior with regard to psychosocial and organizational characteristics. The key domains yield a format enabling a critical appraisal concerning improvement of socio-technologic aspects in case of process innovation. Conclusion; SI yields a format for stimulation of social awareness with regard to self-assessment, interoperability and mindset generation in multidisciplinary teams of professionals.
Kidney Injury in Critically Ill Patients with COVID-19 – From Pathophysiological Mechanisms to a Personalized Therapeutic Model
Authors: Balan Cosmin , Ciuhodaru Tudor , Bubenek-Turconi Serban-Ion
Published: August 2023

Acute kidney injury is a common complication of COVID-19, frequently fuelled by a complex interplay of factors. These include tubular injury and three primary drivers of cardiocirculatory instability: heart-lung interaction abnormalities, myocardial damage, and disturbances in fluid balance. Further complicating this dynamic, renal vulnerability to a “second-hit” injury, like a SARS-CoV-2 infection, is heightened by advanced age, chronic kidney disease, cardiovascular diseases, and diabetes mellitus. Moreover, the influence of chronic treatment protocols, which may constrain the compensatory intrarenal hemodynamic mechanisms, warrants equal consideration. COVID-19-associated acute kidney injury not only escalates mortality rates but also significantly affects long-term kidney function recovery, particularly in severe instances. Thus, the imperative lies in developing and applying therapeutic strategies capable of warding off acute kidney injury and decelerating the transition into chronic kidney disease after an acute event. This narrative review aims to proffer a flexible diagnostic and therapeutic strategy that recognizes the multi-faceted nature of COVID-19-associated acute kidney injury in critically ill patients and underlines the crucial role of a tailored, overarching hemodynamic and respiratory framework in managing this complex clinical condition.
Digital Footprints–Technology and Equality
Authors: Lund Gun
Published: August 2023

How can dancers control or influence variables such as lighting, music, projections or the overall spatial experience that affect the traditional hierarchy in a performative setting? The dance performanceDigital Footprintsuses advanced technologies that allow dancers to test this question in a live situation. In this article, the choreographer discusses some preliminary conclusions.
On a Reduced Component-by-Component Digit-by-Digit Construction of Lattice Point Sets
Authors: Kritzer Peter , Osisiogu Onyekachi
Published: August 2023

In this paper, we study an efficient algorithm for constructing point sets underlying quasi-Monte Carlo integration rules for weighted Korobov classes. The algorithm presented is a reduced fast component-by-component digit-by-digit (CBC-DBD) algorithm, which is useful for situations where the weights in the function space show a sufficiently fast decay. The advantage of the algorithm presented here is that the computational effort can be independent of the dimension of the integration problem to be treated if suitable assumptions on the integrand are met. By considering a reduced digit-by-digit construction, we allow an integration algorithm to be less precise with respect to the number of bits in those components of the problem that are considered less important. The new reduced CBC-DBD algorithm is designed to work for the construction of lattice point sets, and the corresponding integration rules (so-called lattice rules) can be used to treat functions in different kinds of function spaces. We show that the integration rules constructed by our algorithm satisfy error bounds of almost optimal convergence order. Furthermore, we give details on an efficient implementation such that we obtain a considerable speed-up of a previously known CBC-DBD algorithm that has been studied in the paper Digit-by-digit and component-by-component constructions of lattice rules for periodic functions with unknown smoothness by Ebert, Kritzer, Nuyens, and Osisiogu, published in the Journal of Complexity in 2021. This improvement is illustrated by numerical results.
Las cicatrices de la vivienda turística: reducción del mercado residencial inmobiliario y encarecimiento de precios
Authors: De la Encarnación Ana María
Published: August 2023

En este artículo dejamos constancia de la indudable influencia que, sobre el precio de la vivienda residencial, ha tenido la expansión de la vivienda turística. Tal y como recogen numerosos informes, este encarecimiento deriva de la expansión de las plataformas de alojamiento vacacional, como AirBnB, y de la consecuente reducción de oferta en el mercado inmobiliario tradicional por el denominado proceso de conversión de viviendas residenciales en turísticas. Lo que sin duda ha contribuido a dificultar el acceso a la vivienda de los colectivos más vulnerables, acentuando la crisis habitacional.
Estudio comparado del denominado «Mecanismo rural de garantía». Una propuesta para Castilla y León
Authors: Picón Arranz Alberto
Published: August 2023

El objetivo del presente trabajo es la elaboración de una propuesta de un mecanismo rural de garantía para Castilla y León. Para ello, la metodología utilizada ha sido analizar las principales experiencias en esta materia a nivel mundial y la posición de la Unión Europea al respecto. A partir de los casos de éxito en los diferentes países y las características económicas y demográficas de Castilla y León, se puede concluir que la implantación de un sistema que valore la normativa y las políticas públicas desde una óptica rural antes de su aplicación efectiva puede ser de gran utilidad en Castilla y León.
Early diagnosis of Langerhans cells histiocytosis: case report
Authors: Mangueira Gabriela , Trova Victoria , Faria André , Fagundes Fernanda
Published: August 2023

Langerhans' cells histiocytosis is a disease that belongs to the group of histiocytic disorders and is considered a rare pathology. It results from a proliferation and accumulation of cells of the phagocytic mononuclear system, including Langerhans' cells. This paper reports a case of a 4-year-old patient who presented a growing, swollen, nodular, depressible and mobile lesion in the right retroauricular region, without pain or phlogistic signs for 6 months, besides erosive and necrotic lesions in the first and second right molars. The confirmatory diagnosis was made by biopsy and immunohistochemistry. This is a study of the medical record, histological evaluations, laboratory and imaging tests of the patient, with the aim of discussing the pathology, making the diagnosis and treatment earlier.
Quantifying Fear Avoidance Behaviors in People With Concussion: A COSMIN-Informed Systematic Review
Authors: Sherwood Liam J. , Korakakis Vasileios , Mosler Andrea B. , Fortington Lauren , Murphy Myles C.
Published: August 2023

OBJECTIVE: The validity of existing fear avoidance behavior patient-reported outcome measures (PROMs) for concussion is unknown. This study aims to (1) identify PROMs that assess fear avoidance behavior in individuals with concussion and (2) assess the measurement properties of these PROMs.

DESIGN: A systematic review of outcome measurement instruments using the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) checklist.

LITERATURE SEARCH: We performed a systematic search of 7 databases.

STUDY SELECTION CRITERIA: Studies were included if they assessed fear avoidance behavior (eg, kinesiophobia or cogniphobia) in participants with concussion, occurring in all settings (eg, sport, falls, assaults).

DATA SYNTHESIS: Methodological quality of the PROMs was assessed using the COSMIN checklist, and the certainty of the evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach.

RESULTS: We identified 40 studies assessing fear avoidance. Four studies (n = 875 participants, representing 3 PROMs) were eligible for COSMIN assessment. Content validity for all PROMs was insufficient due to extreme risk of bias. The Fear Avoidance Short Form Scale demonstrated the greatest validity: moderate-certainty evidence for sufficient structural validity and internal consistency, and low-certainty evidence for measurement invariance.

CONCLUSION: Current PROMs for measuring fear avoidance behaviors in people with concussion have insufficient content validity and should be used with caution in research and clinical practice. J Orthop Sports Phys Ther 2023;53(9):540-565. Epub: 10 August 2023. doi:10.2519/jospt.2023.11685
Progressing On-Court Rehabilitation After Injury: The Control-Chaos Continuum Adapted to Basketball
Authors: Taberner Matt , Spencer Nathan , Murphy Bryce , Antflick Jarrod , Cohen Daniel Dylan
Published: August 2023

BACKGROUND: Sport-specific training is an integral component of returning to sport following injury. Frameworks designed to guide sport-specific rehabilitation need to integrate and adapt to the specific context of elite sport. The control-chaos continuum (CCC) is a flexible framework originally designed for on-pitch rehabilitation in elite football (soccer). The concepts underpinning the CCC transfer to other elite sport rehabilitation environments.

CLINICAL QUESTION: How can practitioners and clinicians transfer the CCC to elite basketball, to support planning and return to sport? On-court rehabilitation is a critical sport-specific rehabilitation component of return to sport, yet there are no frameworks to guide practitioners when planning and delivering on-court rehabilitation.

KEY RESULTS: Based on our experience working in the National Basketball Association, we report how the CCC framework can apply to elite basketball. We focus on the design and delivery of progressive training in the presence of injury in this basketball-specific edition of the CCC. Given the challenges when quantifying “load” in basketball, we encourage practitioners and clinicians to consider the qualitative aspects of performance such as skill, sport-specific movement, contact, and decision making.

CLINICAL APPLICATION: The 5-phase framework describes training progression from high control, a return to on-court running, to high chaos, a return to “live” unrestricted basketball. The model can be adapted to both short- and long-term injuries based on injury and progression criteria. Strength and power “diagnostics” can be strategically implemented to enhance decision making throughout the return to sport continuum. J Orthop Sports Phys Ther 2023;53(9):498-509. Epub: 9 August 2023. doi:10.2519/jospt.2023.11981
What Factors Do Clinicians, Coaches, and Athletes Perceive Are Associated With Recovery From Low Back Pain in Elite Athletes? A Concept Mapping Study
Authors: Trease Larissa , Mosler Andrea B. , Donaldson Alex , Hancock Mark J. , Makdissi Michael , Wilkie Kellie , Kemp Joanne
Published: August 2023

OBJECTIVE: Identify factors that elite sport clinicians, coaches, and athletes perceive are associated with low back pain (LBP) recovery.

DESIGN: Concept mapping methodology.

METHOD: Participants brainstormed, sorted (thematically), and rated (5-point Likert scales: importance and feasibility) statements in response to the prompt, “What factors are associated with the recovery of an elite athlete from low back pain?” Data cleaning, analysis (multidimensional scaling, hierarchical cluster analysis, and descriptive statistics), and visual representation (cluster map and Go-Zone graph) were conducted following concept mapping guidelines.

RESULTS: Participants (brainstorming, n = 56; sorting, n = 34; and rating, n = 33) comprised 75% clinicians, 15% coaches, and 10% athletes and represented 13 countries and 17 sports. Eighty-two unique and relevant statements were brainstormed. Sorting resulted in 6 LBP recovery–related themes: (1) coach and clinician relationships, (2) inter-disciplinary team factors, (3) athlete psychological factors, (4) athlete rehabilitation journey, (5) athlete non-modifiable risk factors, and (6) athlete physical factors. Participants rated important recovery factors as follows: athlete empowerment and psychology, coach-athlete and athlete-clinician relationships, care team communication, return-to-sport planning, and identifying red flags.

CONCLUSION: Factors perceived as important to LBP recovery in elite athletes align with the biopsychosocial model of community LBP management. Clinicians should consider that an athlete’s psychology, relationships, care team communication, and rehabilitation plan may be as important to their LBP recovery as the formulation of a diagnosis or the medications or exercises prescribed. J Orthop Sports Phys Ther 2023;53(10):610-625. Epub 10 August 2023. doi:10.2519/jospt.2023.11982
Production optimization in Well A and Well B using electric submersible pump (ESP)
Authors: Astuti Weny , Mulyono Wahyu Tri
Published: August 2023

This research discusses the optimization of production carried out in Well A and Well B. The two Wells are production Well with three production layers (multilayer) that have different characteristics for each layer. Based on the performance evaluation of the production Wells, it’s known that Well A and Well B are no longer able to produce naturally (natural flow). Therefore, it’s necessary to have an artificial lift in order to be able to produce.The artificial lift method used for Well A and Well B is to install an electric submersible pump (ESP), because based on the screening criteria of artificial lift, both Wells can use an electric submersible pump. It’s known that Well A has an absolute open flow (AOF) value of 5840 stb/d and Well B of 3874 stb/d. The production optimization carried out has a production target of 70% of the absolute open flow value. Therefore, the selection of the electric submersible pump for each Well must have an operating flowrate that is in accordance with the production target of the two Wells and must perform a sensitivity test on the selected electric submersible pump to obtain the optimal scenario. So that, the electric submersible pump design for Well A is REDA D4300N with operating frequency of 60 hz and 156 stages, while for Well B is REDA DN3100 with operating frequency of 70 hz and 188 stages.
Geothermal Well Casing Design with High Temperature and Corrosive in Q Field
Authors: Wardana Raka , Akhwan Muhammad
Published: August 2023

Casing design is the most crucial phase of drill a geothermal well. As most of problems could be prevented beforehand by having an excellent well casing design. Prior and present well problems may be assessed to enhance casing design mitigate leading causes and its relationship to well casing. This research is about geothermal well casing design by analyzing in advance the problems that the casing may encounter during drilling and production through NPT & casing damage analysis. The purpose is to construct design depth and grade of geothermal well casing from the effects of axial, hoop, and thermal stress, as well as corrosion. The method used is to analyze the NPT from the available DDR data of the wells and then analyze the damage that occurs to the production wells which then the results of these analysis’ become recommendations for of the next well casing design. The results show Well FDL-33 will use tie-back system with surface casing 20” K55 133 ppf at 350 mMD with semi-premium connection, production casing 13-3/8” L80 68 ppf at 1475.8 mMD with premium connection, production tieback casing 13-3 /8” L80 68 ppf at 300 mMD with premium connection, and production liner 9-5/8” L80 40 ppf at 2695.3 mMD with semi-premium connection.
Strain induced reactivity of cyclic iminoboranes: The (2 + 2) cycloaddition of a 1-H-1,3,2-diazaborepine with ethene
Authors: Gupta Divanshu , Einholz Ralf , Bettinger Holger F.
Published: August 2023

Iminoboranes have gathered immense attention due to their reactivity and potential applications as isoelectronic and isosteric alkynes. While cyclic alkynes are well investigated and useful reagents, cyclic iminoboranes are underexplored and their existence was inferred only via trapping experiments. We report the first direct spectroscopic evidence of a cyclic seven-membered iminoborane, 1-(tert-butyldimethylsilyl)-1-H-1,3,2-diazaborepine 2, under cryogenic matrix isolation conditions. The amino-iminoborane 2 was photochemically generated in solid argon at 4 K from 1-(tert-butyldimethylsilyl)-2-azido-1,2-dihydro-1,2-azaborine (3) and was characterized using FT-IR, UV-Vis spectroscopy, and computational chemistry. The characteristic BN stretching vibration (1751 cm-1) is shifted by about 240 cm-1 compared to linear amino-iminoboranes indicating a significant weakening of the bond. The Lewis acidity value determined computationally (LAB = 9.1 ± 2.6) is similar to that of boron trichloride, and twelve orders of magnitude lower than that of 1,2-azaborinine (BN-aryne, LAB = 21.5 ± 2.6), a six-membered cyclic iminoborane. In contrast to the latter, the reduced ring strain of 2 precludes nitrogen fixation, but it unexpectedly allows facile (2 + 2) cycloaddition reaction with C2H4 under matrix isolation conditions at 30 K. The reaction of 2 with ethene provides the first example of a (2 + 2) cycloaddition reaction of an iminoborane.
Surfactant delivery systems for enhanced oil recovery
Authors: C. B. Maia Kelly , dos S. Francisco Agatha Densy , Grasseschi Daniel , S. V. Nascimento Regina
Published: August 2023

Global consumption of petroleum is increasing, and there is a significant prospect of a further surge in oil demand in the upcoming years. An alternative to meet this energy need is the increase of oil recovery in new or mature oils reservoirs. Research in the advanced oil recovery sector, specifically focusing on surfactant injection, has shown promising results and the potential to contribute to global oil production. However, the high costs associated with surfactant injection, attributed to losses through adsorption on the rock, is a major concern. Surfactants play a crucial role in reducing interfacial tension and modifying wettability, crucial parameters to increase the oil recovery factor. To mitigate the issues of surfactant injection, the utilization of surfactant carriers has proven effective. This comprehensive article reviews four major classes of surfactant-carrying materials, namely inorganic nanoparticles, carbon materials, polymers, and supramolecular systems, with the objective of minimizing surfactant loss in enhanced oil recovery. The review identifies challenges, proposes alternative approaches, and explores opportunities for applying different surfactant nanocarrires systems for EOR. Furthermore, it discusses the classification, mechanisms of action, and synergistic effects between carrier-surfactant systems, addressing the importance of systematically grouping these systems for the advancement of science and technology. The review also highlights the permeation capabilities of these carrier materials through porous media, their size-based rock adsorption, and the potential synergistic effects on interfacial properties in the reservoir. By examining these aspects, innovative techniques for EOR can be developed and a deeper understanding of the subject can be achieved.
PENONJOLAN PERAN SEMANTIS DAN KONSTRUKSI GRAMATIKAL PASANGAN VERBA -I DAN -KAN: KAJIAN GRAMATIKA KONSTRUKSIONAL BERBASIS KORPUS ATAS MENAWARI/MENAWARKAN
Authors: Rajeg Gede Primahadi Wijaya
Published: August 2023

This paper presents quantitative corpus analyses of the profiled participant/semantic roles and the preferred grammatical constructions of semantically similar Indonesian verb-pair suffixed with -i and -kan. Menawari/menawarkan ‘to offer’ pair is chosen as a case study. Couched within the Construction Grammar and Frame Semantics theories, the analyses revealed that each verb differs regarding the profiled semantic roles within the preferred grammatical constructions the verb occurs in. Menawari strongly profiles Offerer, Potential_recipient and Theme in Double-Object Construction, while menawarkan only profiles Offerer and Theme in Monotransitive Construction. Although the quantitative findings confirm the theoretical hypothesis of the constructional behaviours for menawari/menawarkan, the study also discovers previously unpredicted constructional variation for menawari. Such variation (i) has a typological implication concerning the grammatical alignments of trivalent verbs and (ii) raises an intriguing question regarding constructional contamination by the constructional profile of the more frequent form (i.e., menawarkan) that is paradigmatically related to menawari.
Skewed X-inactivation is associated with retinal dystrophy in female carriers ofRPGRmutations
Authors: Usman Muhammad , Jüschke Christoph , Song Fei , Kastrati Dennis , Owczarek-Lipska Marta , Eilers Jannis , Pauleikhoff Laurenz , Lange Clemens , Neidhardt John
Published: August 2023

Progressive degeneration of rod and cone photoreceptors frequently is caused by mutations in the X-chromosomal gene Retinitis Pigmentosa GTPase Regulator (RPGR). Males hemizygous for aRPGRmutation often are affected by Retinitis Pigmentosa (RP), whereas female mutation carriers only occasionally present with severe RP phenotypes. The underlying pathomechanism leading to RP in female carriers is not well understood. Here, we analyzed a three-generation family in which two of three female carriers of a nonsenseRPGRmutation presented with RP. Among two cell lines derived from the same female family members, differences were detected inRPGRtranscript expression, in localization of RPGR along cilia, as well as in primary cilium length. Significantly, these differences correlated with alterations in X-chromosomal inactivation patterns found in the patient-derived cell lines from females. In summary, our data suggest that skewed X-chromosomal inactivation is an important factor that determines the disease manifestation of RP among female carriers of pathogenic sequence alterations in theRPGRgene.
HGF/c-Met/β1-integrin signalling axis induces tunneling nanotubes in A549 lung adenocarcinoma cells
Authors: Awanis Griselda , Banerjee Salonee , Johnson Robert , Raveenthiraraj Sathuwarman , Elmeligy Aya , Warren Derek , Gavrilovic Jelena , Sobolewski Anastasia
Published: August 2023

Tunneling nanotubes (TNTs) are thin cytoplasmic extensions involved in long-distance intercellular communication and can transport intracellular organelles and signalling molecules. In cancer cells, TNT formation contributes to cell survival, chemoresistance, and malignancy. However, the molecular mechanisms underlying TNT formation are not well defined, especially in different cancers. TNTs are present in non-small cell lung cancer (NSCLC) patients with adenocarcinoma. In NSCLC, hepatocyte growth factor (HGF) and its receptor, c-Met, are mutationally upregulated, causing increased cancer cell growth, survival, and invasion. This study identifies c-Met, β1-integrin, and paxillin as novel components of TNTs in A549 lung adenocarcinoma cells, with paxillin localised at the protrusion site of TNTs. The HGF-induced TNTs in our study demonstrate the ability to transport lipid vesicles and mitochondria. HGF-induced TNT formation is mediated by c-Met and β1-integrin in conjunction with paxillin, followed by downstream activation of MAPK and PI3K pathways and the Arp2/3 complex. These findings demonstrate a potential novel approach to inhibit TNT formation through targeting HGF/c-Met receptor and β1-integrin signalling interactions, which has implications for multi-drug targeting in NSCLC.
PASCAR: a multiscale framework to explore the design space of constitutive and inducible CAR T cells
Authors: Rajakaruna Harshana , Desai Milie , Das Jayajit
Published: August 2023

CAR T cells are engineered to bind and destroy tumor cells by targeting overexpressed surface antigens. However, healthy cells expressing lower abundances of these antigens can also be lysed by CAR T cells. Various CAR T cell designs increase tumor cell elimination, whereas reducing damage to healthy cells. However, these efforts are costly and labor-intensive, constraining systematic exploration of potential hypotheses. We develop a protein abundance structured population dynamic model for CAR T cells (PASCAR), a framework that combines multiscale population dynamic models and multi-objective optimization approaches with data from cytometry and cytotoxicity assays to systematically explore the design space of constitutive and tunable CAR T cells. PASCAR can quantitatively describe in vitro and in vivo results for constitutive and inducible CAR T cells and can successfully predict experiments outside the training data. Our exploration of the CAR design space reveals that optimal CAR affinities in the intermediate range of dissociation constants effectively reduce healthy cell lysis, whereas maintaining high tumor cell-killing rates. Furthermore, our modeling offers guidance for optimizing CAR expressions in synthetic notch CAR T cells. PASCAR can be extended to other CAR immune cells.