bluuebunny/crossref_metadata_2025 huggingface dataset:
Case Report: High-Dose Ferric Carboxymaltose as an Antianaemic Agent to Avoid Haemotransfusions after Total Hip Replacement
Authors: Konkayeva Maiya , Kadralinova Assiya , Zhanarystan Nazerke , Akhatov Nurlan , Konkayev Aidos
Published: August 2024

This article highlights a case of high-dose ferric carboxymaltose (Ferinject®) for the treatment of perioperative iron deficiency anaemia in a 39-year-old patient with dysplastic coxarthrosis. The patient was admitted routinely for a total hip replacement of the left hip joint. She had been suffering from pain, lameness, and restriction of movement in her left hip joint for the past several years. The patient was admitted with initial iron deficiency anaemia of a medium severity (Hgb—96.5 g/L, RBC—3.97 × 1012/L). Laboratory tests were taken to determine the iron deficiency, and transfusion readiness was submitted. The patient received ferric carboxymaltose infusion before surgery. The intraoperative blood loss was—100 mL with an operation duration of 50 min. On the first postoperative day, haemoglobin decreased to 86 g/L. No haemoglobin decrease was observed in the postoperative period, and 92 g/L was the amount of haemoglobin at the time of hospital discharge. The optimal dose for the treatment of perioperative anaemia has not been established; some studies recommend ferric carboxymaltose at a dose of 15 to 20 mg/kg and a maximum of 1000 mg once on the first day after surgery. The uniqueness of this case report is that a high dose of ferric carboxymaltose (1340 mg) during the preoperative period was applied. No side effects such as hypophosphatemia were reported. We believe that, in this clinical case, the patient managed to avoid large intraoperative blood loss and transfusions by using high doses of ferric carboxymaltose.
The Relationship between Body Mass Index and Frontal QRS-T Angle in Pregnant Women Undergoing Cesarean Section with Spinal Anesthesia
Authors: Tercan Mehmet , Bingol Tanriverdi Tugba , Komurcu Nurseda , Esercan Alev , Kaya Ahmet , Ozyurt Erhan , Tanriverdi Zulkif
Published: August 2024

Background and objectives: The frontal QRS-T angle is a novel parameter of myocardial repolarization. Weight gain during pregnancy and physiological changes during a cesarian section may affect the frontal QRS-T angle. We aimed to assess the effect of body mass index (BMI) on the frontal QRS-T angle in pregnant women undergoing cesarean section with spinal anesthesia. Method and materials: This study included 90 pregnant women. BMI was calculated for all pregnant women. The study population was divided into two groups: BMI < 30 (n = 66) and BMI ≥ 30 (n = 24). QT interval measurements and the frontal QRS-T angle were obtained from the report of an electrocardiography machine. Results: It was found that the pre-operative and post-operative frontal QRS-T angle (p = 0.045 and p = 0.007) and QTc interval (p = 0.037 and p < 0.001) were higher in pregnant women with a BMI ≥ 30 than in pregnant women with a BMI < 30. In addition, when compared to pre-operative values, the post-operative frontal QRS-T angle (from 24.0 [20.0–41.5] to 34.5 [19.5–50.0], p = 0.031) and QTc interval (from 420.6 ± 13.3 to 431.7 ± 18.3, p = 0.010) were increased in the BMI ≥ 30 group, whereas no significant post-operative increase was observed in the BMI < 30 group. In correlation analysis, BMI was positively correlated with the frontal QRS-T angle and QTc interval. Conclusions: The frontal QRS-T angle and QTc interval were importantly increased in pregnant women with a BMI ≥ 30 than in pregnant women with a BMI < 30. Also, after cesarean section operation with spinal anesthesia, the frontal QRS-T angle and QTc were increased significantly in the BMI ≥ 30 group, whereas no significant change was observed in the BMI < 30 group. Therefore, it is suggested to perform close post-operative monitoring in pregnant women with a BMI ≥ 30 undergoing cesarean section with spinal anesthesia.
Optimizing Tempering Parameters to Enhance Precipitation Behavior and Impact Toughness in High-Nickel Steel
Authors: Sun Guojin , Wang Qi
Published: August 2024

This study explores the effects of tempering on the precipitation behavior and impact toughness of high-nickel steel. The specimens underwent double quenching at 870 °C and 770 °C, followed by tempering at various temperatures. Advanced characterization techniques including optical microscopy (OM), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) were used to elucidate precipitation phenomena. Additionally, electron backscatter diffraction (EBSD) was employed to assess the misorientation distribution after tempering. Charpy impact tests were performed on specimens tempered at different temperatures to evaluate their toughness. The findings reveal that with increasing tempering temperature, the fraction of low-angle grain boundaries decreases, which correlates positively with enhanced impact toughness. The results demonstrate that tempering at 580 °C optimizes the material’s microstructure, achieving an impact toughness value of approximately 163 J.
Phase Mapping Using a Combination of Multi-Functional Scanning Electron Microscopy Detectors and Imaging Modes
Authors: Liu Gang , Zhao Yonghua , Wang Shuai
Published: August 2024

Microstructure degradation and phase transformations are critical concerns in nickel-based superalloys during thermal exposure. Understanding the phase transformation mechanism requires the detailed mapping of the distribution of each phase at different degradation stages and in various precipitation sizes. However, differentiating between phases in large areas, typically on the scale of millimeters and often relying on scanning electron microscopy (SEM) techniques, has traditionally been a challenging task. In this study, we present a novel and efficient phase mapping method that leverages multiple imaging detectors and modes in SEM. This approach allows for the relatively rapid and explicit differentiation and mapping of the distribution of various phases, including MC, M23C6, γ′, and η phases, as demonstrated in a typical superalloy subjected to aging experiments at 800 °C.
Probiotics in miRNA-Mediated Regulation of Intestinal Immune Homeostasis in Pigs: A Physiological Narrative
Authors: Bárcenas-Preciado Valeria , Mata-Haro Verónica
Published: August 2024

The microbiota plays a crucial role in maintaining the host’s intestinal homeostasis, influencing numerous physiological functions. Various factors, including diet, stress, and antibiotic use, can lead to such imbalances. Probiotics have been shown to restore the microbiota, contributing to maintaining this balance. For instance, the weaning stage in piglets is crucial; this transition can cause unfavorable changes that may contribute to the onset of diarrhea. Probiotic supplementation has increased due to its benefits. However, its mechanism of action is still controversial; one involves the regulation of intestinal immunity. When recognized by immune system cells through membrane receptors, probiotics activate intracellular signaling pathways that lead to changes in gene expression, resulting in an anti-inflammatory response. This complex regulatory system involves transcriptional and post-transcriptional mechanisms, including the modulation of various molecules, emphasizing microRNAs. They have emerged as important regulators of innate and adaptive immune responses. Analyzing these mechanisms can enhance our understanding of probiotic–host microbiota interactions, providing insights into their molecular functions. This knowledge can be applied not only in the swine industry, but also in studying microbiota-related disorders. Moreover, these studies serve as animal models, helping to understand better conditions such as inflammatory bowel disease and other related disorders.
Clostridium perfringens in the Intestine: Innocent Bystander or Serious Threat?
Authors: Ba Xuli , Jin Youshun , Ning Xuan , Gao Yidan , Li Wei , Li Yunhui , Wang Yihan , Zhou Jizhang
Published: August 2024

The Clostridium perfringens epidemic threatens biosecurity and causes significant economic losses. C. perfringens infections are linked to more than one hundred million cases of food poisoning annually, and 8–60% of susceptible animals are vulnerable to infection, resulting in an economic loss of more than 6 hundred million USD. The enzymes and toxins (>20 species) produced by C. perfringens play a role in intestinal colonization, immunological evasion, intestinal micro-ecosystem imbalance, and intestinal mucosal disruption, all influencing host health. In recent decades, there has been an increase in drug resistance in C. perfringens due to antibiotic misuse and bacterial evolution. At the same time, traditional control interventions have proven ineffective, highlighting the urgent need to develop and implement new strategies and approaches to improve intervention targeting. Therefore, an in-depth understanding of the spatial and temporal evolutionary characteristics, transmission routes, colonization dynamics, and pathogenic mechanisms of C. perfringens will aid in the development of optimal therapeutic strategies and vaccines for C. perfringens management. Here, we review the global epidemiology of C. perfringens, as well as the molecular features and roles of various virulence factors in C. perfringens pathogenicity. In addition, we emphasize measures to prevent and control this zoonotic disease to reduce the transmission and infection of C. perfringens.
Advances in Research on Bacterial Oxidation of Mn(II): A Visualized Bibliometric Analysis Based on CiteSpace
Authors: Mo Wentao , Wang Hang , Wang Jianghan , Wang Yue , Liu Yunfei , Luo Yi , He Minghui , Cheng Shuang , Mei Huiting , He Jin , Su Jianmei
Published: August 2024

Manganese (Mn) pollution poses a serious threat to the health of animals, plants, and humans. The microbial-mediated Mn(II) removal method has received widespread attention because of its rapid growth, high efficiency, and economy. Mn(II)-oxidizing bacteria can oxidize toxic soluble Mn(II) into non-toxic Mn(III/IV) oxides, which can further participate in the transformation of other heavy metals and organic pollutants, playing a crucial role in environmental remediation. This study aims to conduct a bibliometric analysis of research papers on bacterial Mn(II) oxidation using CiteSpace, and to explore the research hotspots and developmental trends within this field between 2008 and 2023. A series of visualized knowledge map analyses were conducted with 469 screened SCI research papers regarding annual publication quantity, author groups and their countries and regions, journal categories, publishing institutions, and keywords. China, the USA, and Japan published the most significant number of research papers on the research of bacterial Mn(II) oxidation. Research hotspots of bacterial Mn(II) oxidation mainly focused on the species and distributions of Mn(II)-oxidizing bacteria, the influencing factors of Mn(II) oxidation, the mechanisms of Mn(II) oxidation, and their applications in environment. This bibliometric analysis provides a comprehensive visualized knowledge map to quickly understand the current advancements, research hotspots, and academic frontiers in bacterial Mn(II) oxidation.
Density Functional Theory Study on Structure and Properties of Sulfurized Cerussite (110) Surface
Authors: Han Cong , Ao Yuxin , Shen Yanbai , Zhao Sikai , Zhao Qiang , Zhou Shijie
Published: August 2024

Cerussite is an essential lead oxide mineral with increasing economic importance as lead sulfide resources deplete. This study utilizes density functional theory (DFT) to investigate the structural and electronic properties of the sulfurized cerussite (110) surface. The results show that when the cerussite crystal cleaves along the (110) plane, only the surface layer atoms undergo relaxation to reconstruct the surface, while the atoms located deeper have almost no impact on the reconstructed surface structure. The Pb atoms on the cerussite (110) surface react with the sulfurizing agent to form a PbS deposition layer with a structure similar to galena. This PbS deposition layer is tightly adsorbed onto the lead oxide layer through Pb-S bonds formed by S and subsurface lead oxide structure Pb atoms. The chemical reactivity of Pb atoms in the PbS layer on the sulfurized cerussite (110) surface is more potent than that of Pb atoms on the galena surface; additionally, the Pb atoms closer to the lead oxide layer exhibit slightly higher chemical reactivity than those farther away. This study provides insight into sulfurized cerussite surfaces’ structure and properties at an atomic level and assists in explaining the floating behavior of cerussite.
Nitrogen-Tungsten Oxide Nanostructures on Nickel Foam as High Efficient Electrocatalysts for Benzyl Alcohol Oxidation
Authors: Zhu Yizhen , Chen Xiangyu , Zhang Yuanyao , Zhu Zhifei , Chen Handan , Chai Kejie , Xu Weiming
Published: August 2024

Electrocatalytic alcohol oxidation (EAO) is an attractive alternative to the sluggish oxygen evolution reaction in electrochemical hydrogen evolution cells. However, the development of high-performance bifunctional electrocatalysts is a major challenge. Herein, we developed a nitrogen-doped bimetallic oxide electrocatalyst (WO-N/NF) by a one-step hydrothermal method for the selective electrooxidation of benzyl alcohol to benzoic acid in alkaline electrolytes. The WO-N/NF electrode features block-shaped particles on a rough, inhomogeneous surface with cracks and lumpy nodules, increasing active sites and enhancing electrolyte diffusion. The electrode demonstrates exceptional activity, stability, and selectivity, achieving efficient benzoic acid production while reducing the electrolysis voltage. A low onset potential of 1.38 V (vs. RHE) is achieved to reach a current density of 100 mA cm−2 in 1.0 M KOH electrolyte with only 0.2 mmol of metal precursors, which is 396 mV lower than that of water oxidation. The analysis reveals a yield, conversion, and selectivity of 98.41%, 99.66%, and 99.74%, respectively, with a Faradaic efficiency of 98.77%. This work provides insight into the rational design of a highly active and selective catalyst for electrocatalytic alcohol oxidation.
Investigation into the Sonodynamic Activity of Three Newly Synthesized Derivatives of Ciprofloxacin
Authors: Zheng Ying , Lv Jing , Zhang Jun , Liu Yu , Wang Xiaofang , Liu Bin
Published: August 2024

Sonosensitizers play a crucial role in the efficacy of sonodynamic antitumor therapy (SDT) and sonodynamic antimicrobial chemotherapy (SACT), highlighting the necessity for the development of new compounds with good sonodynamic activity. In this study, three novel 3-substituted ciprofloxacin derivatives (CIPD1, CIPD2, and CIPD3) were designed and synthesized. Their sonodynamic activities were evaluated by assessing the damage to bovine serum albumin (BSA) and Escherichia coli (E. coli). Furthermore, the potential mechanism underlying their sonodynamic damage activities was investigated by detecting reactive oxygen species (ROS) under ultrasound irradiation (US). The results demonstrated that all three derivatives exhibited enhanced sonodynamic damage to BSA and E. coli under US, with CIPD1 and CIPD2 showing superior effectiveness compared to CIP. Both the concentrations of derivatives and the duration of ultrasound irradiation were found to significantly impact their sonodynamic effects. All three CIP derivates could be activated to produce ROS following ultrasound irradiation, primarily consisting of 1O2 and ·OH. The levels of ROS production were positively correlated with their sonodynamic activities, potentially explaining the mechanism underlying their sonodynamic damage activities.
Why Do Ionic Surfactants Significantly Alter the Chemiluminogenic Properties of Acridinium Salt?
Authors: Mańkowska Magdalena , Krzymiński Karol , Wyrzykowski Dariusz , Zadykowicz Beata , Samsonov Sergey A.
Published: August 2024

Acridinium esters, due to their capability for chemiluminescence (CL), are employed as indicators and labels in biomedical diagnostics and other fields. In this work, the influence of ionic surfactants, hexadecyltrimethylammonium chloride and bromide (CTAC and CTAB, cationic) and sodium dodecyl sulphate (SDS, anionic) on the CL parameters and mechanism of representative emitter, 10-methyl-9-[(2-methylphenoxy)carbonyl]acridinium trifluoromethanesulphonate (2MeX) in a H2O2/NaOH environment, is studied. Our investigations revealed that the type of surfactant and its form in solution have an impact on the CL kinetic constants and integral efficiencies, while changes in those emission properties resulting from the type of ion (Cl− vs. Br−) are negligible. The major changes were recorded for systems containing surfactants at concentrations higher than the critical micelle concentration. The cationic surfactants (CTAC, CTAB) cause a substantial increase in CL emission kinetics and a moderate increase in its integral efficiency. At the same time, the opposite effect is observed in the case of SDS. Molecular dynamics simulations suggest that changes in emission parameters are likely due to differences in the binding strength of 2MeX substrate with surfactant molecules, which is higher for SDS than for CTAC. The results can help in rational designing of optimal acridinium CL systems and demonstrate their usefulness in distinguishing the pre- and post-micellar environment and the charge of surfactants.
Asymmetric Hydrogenation of Ketones by Simple Alkane-Diyl-Based Ir(P,N,O) Catalysts: A Comparative Study
Authors: Császár Zsófia , Guóth Mária , Kovács Margit , Bényei Attila C. , Bakos József , Farkas Gergely
Published: August 2024

The development of new chiral ligands with simple and modular structure represents a challenging direction in the design of efficient homogeneous transition metal catalysts. Herein, we report on the asymmetric hydrogenation of prochiral ketones catalyzed by the iridium complexes of simple alkane-diyl-based P,N,O-type chiral ligands with a highly modular structure. The role of (i) the P-N and N-O backbone in the potentially tridentate ligands, (ii) the number, position and relative configuration of their stereogenic elements and (iii) the effect of their NH and OH subunits on the activity and enantioselectivity of the catalytic reactions are studied. The systematic variation in the ligand structure and the comparative catalytic experiments shed light on different mechanistic aspects of the iridium-catalyzed reaction. The catalysts containing the simple alkane-diyl-based ligands with central chirality provided high enantioselectivities (up to 98% ee) under optimized reaction conditions and proved to be active and selective even at very high substrate concentrations (100 mmol substrate/mL solvent).
Turkey Hemorrhagic Enteritis (THE): A Short Overview
Authors: Musa Laura , Rapi Maria Cristina , Franciosini Maria Pia , Lupini Caterina , Catelli Elena , Addis Maria Filippa , Grilli Guido
Published: August 2024

Turkey Hemorrhagic Enteritis (THE) is an acute disease caused by a Siadenovirus that affects 4 week-aged and older turkeys, characterized by acute depression, bloody droppings, and a high mortality rate. The immunosuppressive attributes of THE can protract disease progression and create a predisposition in birds towards subsequent bacterial infectiodoralns involving Escherichia coli and Clostridium perfringens (necrotic enteritis). Turkey Hemorrhagic Enteritis Virus (THEV) predominantly affects turkeys and carries substantial economic implications for this industry. Macrophages and B lymphocytes are recognized as the predominant target cells for the virus, while the spleen is the principal site of viral replication. Infected cells have also been observed in various other tissues, including the intestines, bursa of Fabricius, cecal tonsils, thymus, liver, kidney, peripheral blood leukocytes, and lungs. The economic relevance of this disease is derived both from the high mortality rate, which can reach 60% depending on the virulence of the strain, and from subclinical disease responsible for poor performance in vaccinated animals. This review aims to provide a comprehensive overview of THE, spanning etiology, epidemiology clinical signs and gross lesions, prevention, and management.
Persistence of Salmonella and Campylobacter on Whole Chicken Carcasses under the Different Chlorine Concentrations Used in the Chill Tank of Processing Plants in Sri Lanka
Authors: Weerasooriya Gayani , Dulakshi H. M. T. , de Alwis P. S. , Bandara Sandun , Premarathne K. R. P. S. , Dissanayake Nayanajith , Liyanagunawardena N. , Wijemuni M. I. , Priyantha M. A. R.
Published: August 2024

The persistence of non-typhoidal Salmonella and Campylobacter in chicken meat is a considerable public health risk and a future challenge. This study aimed to determine the prevalence of Salmonella and Campylobacter in poultry processing lines where different chlorine concentrations were used in the chill tank. The samples were collected from four types of processing plants in Sri Lanka, considering the chlorine concentration used in the chill tank, which ranged from 2 ppm to 50 ppm. Salmonella and Campylobacter were isolated from whole carcass washings, neck skin, and cecal samples. Subsequently, an antimicrobial susceptibility test was performed for the isolates. The results revealed the overall prevalence of Salmonella and Campylobacter was 78.25% and 63.5%, respectively. Positive percentages of Salmonella and Campylobacter were high in the carcasses compared to the neck skin and ceca. The Campylobacter counts on the whole carcasses were significantly low (p < 0.001), at higher chlorine concentrations ranging from 20 to 30 ppm and 40 to 50 ppm. The pathogen prevalence in the whole carcasses was 84.7% Campylobacter coli, 39.1% Campylobacter jejuni, 71.1% Salmonella Typhimurium, and 28.8% Salmonella Infantis. The highest resistance was observed for tetracycline (63.8%) in Salmonella, while it was for gentamicin (87.8%) in Campylobacter. The prevalence percentage of multidrug-resistant Campylobacter was 51.2%, while it was 2.12% for Salmonella. The persistence of multidrug-resistant Salmonella and Campylobacter on the post-chill carcasses was highlighted in the present study as a significant public health threat that has to be addressed urgently.
Diversity of Free-Living Amoebae in New Zealand Groundwater and Their Ability to Feed on Legionella pneumophila
Authors: Ariyadasa Sujani , van Hamelsveld Sophie , Taylor William , Lin Susan , Sitthirit Panan , Pang Liping , Billington Craig , Weaver Louise
Published: August 2024

Free-living amoebae (FLA) are common in both natural and engineered freshwater ecosystems. They play important roles in biofilm control and contaminant removal through the predation of bacteria and other taxa. Bacterial predation by FLA is also thought to contribute to pathogen dispersal and infectious disease transmission in freshwater environments via the egestion of viable bacteria. Despite their importance in shaping freshwater microbial communities, the diversity and function of FLA in many freshwater ecosystems are poorly understood. In this study, we isolated and characterized FLA from two groundwater sites in Canterbury, New Zealand using microbiological, microscopic, and molecular techniques. Different methods for groundwater FLA isolation and enrichment were trialed and optimized. The ability of these isolated FLA to predate on human pathogen Legionella pneumophila was assessed. FLA were identified by 18S metagenomic amplicon sequencing. Our study showed that Acanthamoeba spp. (including A. polyphaga) and Vermamoeba veriformis were the main FLA species present in both groundwater sites examined. While most of the isolated FLA co-existed with L. pneumophila, the FLA populations in the L. pneumophila co-culture experiments predominantly consisted of A. polyphaga, Acanthamoeba spp., Naegleria spp., V. vermiformis, Paravahlkampfia spp., and Echinamoeba spp. These observations suggest that FLA may have the potential to act as reservoirs for L. pneumophila in Canterbury, New Zealand groundwater systems and could be introduced into the local drinking water infrastructure, where they may promote the survival, multiplication, and dissemination of Legionella. This research addresses an important gap in our understanding of FLA-mediated pathogen dispersal in freshwater ecosystems.
Tunable Photonic Hook Design Based on Anisotropic Cutting Liquid Crystal Microcylinder
Authors: Li Renxian , Tang Huan , Zhang Mingyu , Liu Fengbei , Yang Ruiping , Khaleel Naila , Arfan Muhammad , Asif Muhammad , Minin Igor V. , Minin Oleg V.
Published: August 2024

The selective control and manipulation of nanoparticles require developing and researching new methods for designing optical tweeters, mainly based on a photonic hooks (PHs) effect. This paper first proposes a tunable PH in which a structured beam illuminates an anisotropic cutting liquid crystal microcylinder based on the Finite-DifferenceTime-Domain (FDTD) method. The PHs generated by plane wave, Gaussian, and Bessel beam are analyzed and compared. The impact of beams and LC particle parameters on the PHs are discussed. Where the influence of the extraordinary refractive index (ne) on PHs is emphasized. Our results reveal that introducing birefringence can change the bending direction of PH. Besides, the maximum intensity of the PHs increases as ne increases regardless of the beam type. The PH generated by a plane wave has a higher maximum intensity and smaller FWHM than that generated by the Gaussian and Bessel beams. The smallest FWHM and maximum intensity of the PHs generated by the Gaussian falls between that generated by the plane wave and the Bessel beam. The PH generated by a Bessel beam has the minor maximum intensity and the largest FWHM. Still, it exceeds the diffraction limit and exhibits bending twice due to its self-recovery property. This paper provides a new way to modulate PH. This work offers novel theoretical models and the degree of freedom for the design of PHs, which is beneficial for the selective manipulation of nanoparticles. It has promising applications in Mesotronics and biomedicine.
From Inundations to Golden Opportunity: Turning Holopelagic Sargassum spp. into a Valuable Feed Ingredient through Arsenic Removal
Authors: Cisneros-Ramos Karla Itzel , Gutiérrez-Castañeda Montserrat , Magaña-Gallegos Edén , Villegas-Pañeda Alejandra G. , Monroy-Velázquez Luz Verónica , Barba-Santos María Guadalupe , Gaxiola-Cortés Martha Gabriela , van Tussenbroek Brigitta I.
Published: August 2024

For over a decade, numerous Greater Caribbean and Western African coasts have received enormous masses of holopelagic Sargassum spp. (sargasso). A promising use of this beached biomass as a feed ingredient in the animal industry is restricted by its high arsenic (As) content. This proof of concept aimed to demonstrate that simple, low-cost processes involving hot water (either fresh or seawater) and/or citric acid can remove arsenic from the sargasso. Sargasso collected from a Mexican Caribbean beach in December 2023 had a total arsenic level of 62.2 mg/kg, which decreased to 7.2 mg/kg after treatment with hot freshwater (90 °C for 15 min), and then further decreased to 0.8 mg/kg when followed up with a citric acid treatment. Sargasso collected in March 2024 had total arsenic of 89 mg/kg, which was lowered to 2.6 mg/kg by applying hot freshwater and citric acid sequentially. Employing only citric acid reduced the arsenic concentration to 8.0 mg/kg, while treating the sargasso only with hot seawater reduced the As level to 10.1 mg/kg. Thus, simply using hot water, either fresh or seawater, lowered the arsenic levels to acceptable levels for the animal feeding sector. These straightforward and potentially cost-effective methods may transform the restraint of high arsenic contents into a valuable opportunity to use these seaweeds as animal feed.
Metabolomic Analyses Reveal That IAA from Serratia marcescens Lkbn100 Promotes Plant Defense during Infection of Fusarium graminearum in Sorghum
Authors: Yan Jichen , Qi Nawei , Xu Jing , Hu Lan , Jiang Yu , Bai Yuanjun
Published: August 2024

Global sorghum production has been significantly reduced due to the occurrence of sorghum root rot caused by the fungus Fusarium graminearum. The utilization of biocontrol microorganisms has emerged as an effective strategy. However, the underlying mechanisms remain unclear. Therefore, the aim of this study was to investigate the effectiveness of biocontrol bacteria in inducing sorghum resistance against sorghum root rot and explore the potential induced resistance mechanisms through metabolomics analysis. The results revealed that the biocontrol bacteria Lnkb100, identified as Serratia marcescens (GenBank: PP152264), significantly enhanced the resistance of sorghum against sorghum root rot and promoted its growth, leading to increased seed weight. Targeted metabolomics analysis demonstrated that the highest concentration of the hormone IAA (indole-3-acetic acid) was detected in the metabolites of Lnkb100. Treatment with IAA enhanced the activity of disease-related enzymes such as SOD, CAT, POD and PPO in sorghum, thereby improving its resistance against sorghum root rot. Further untargeted metabolomic analysis revealed that IAA treatment resulted in higher concentrations of metabolites involved in the resistance against F. graminearum, such as geniposidic acid, 5-L-Glutamyl-taurine, formononetin 7-O-glucoside-6″-O-malonate, as well as higher concentrations of the defense-related molecules volicitin and JA. Additionally, “secondary bile acid biosynthesis” and “glycerophospholipid metabolism” pathways were found to play significant roles in the defense response of sorghum against fungal infection. These findings provide a reliable theoretical basis for utilizing biocontrol microorganisms to control sorghum root rot.
Polymeric Mixed Micelle-Loaded Hydrogel for the Ocular Delivery of Fexofenadine for Treating Allergic Conjunctivitis
Authors: El-Shahed Sherouk A. , Hassan Doaa H. , El-Nabarawi Mohamed A. , El-Setouhy Doaa Ahmed , Abdellatif Menna M.
Published: August 2024

This study was designed to formulate a polymeric mixed micelle (PMM) formulation to sustainably release fexofenadine (FEX) to treat allergic conjunctivitis effectively. A 32 factorial design was employed where the studied factors were PL90G amount (X1) and Pluronic (F127 and P123) mixture ratio (X2), and the dependent variables were entrapment efficacy (EE, Y1, %), particle size (PS, Y2, nm), zeta potential (ZP, Y3, mV), and the percent of drug released after 6 h (Q6h, Y4, %). The optimized formula was blended with a hydrogel base to develop an FEX-PMM hydrogel, where the safety and efficiency of this hydrogel were evaluated using in vivo studies. The EE% of FEX-PMM ranged from 62.15 ± 2.75 to 90.25 ± 1.48%, the PS from 291.35 ± 6.43 to 467.95 ± 3.60 nm, the ZP from −5.41 ± 0.12 to −9.23 ± 0.23 mV, and the Q6h from 50.27 ± 1.11 to 95.38 ± 0.92%. The Draize test results confirmed the safety of the FEX-PMM hydrogel. Furthermore, the FEX-PMM hydrogel showed rapid recovery in animals with induced allergic conjunctivitis compared to the free drug hydrogel. These results assure PMM’s capability to deliver FEX to the conjunctival surface in a sustained pattern, consequently achieving better therapeutic outcomes.
Development of Dynamic Four-Dimensional Printing Technology for Patterned Structures by Applying Microcellular Foaming Process
Authors: Kim Kwan Hoon , Kim Jae Hoo , Hong Jin , Cha Sung Woon
Published: August 2024

Four-dimensional (4D) printing adds the dimension of time to 3D-printed specimens, causing movement when external stimuli are applied. This movement enables applications across various fields, including the soft robotics, aerospace, apparel, and automotive industries. Traditionally, 4D printing has utilized special materials such as shape-memory polymers (SMPs) or shape-memory alloys (SMAs) to achieve this movement. This study explores a novel approach to 4D printing by applying microcellular foaming processes (MCPs) to 3D printing. This study primarily aims to design and fabricate patterned specimens using common materials, such as PLA, through 3D printing and to analyze their dynamic behavior under various foaming conditions. To demonstrate the potential applications of this technology, the degree of bending was measured by controlling the patterning and foaming conditions. The 3D-printed specimens with microcellular foaming exhibited predictable deformations owing to the asymmetric expansion caused by differential gas saturation. The results confirm that 4D printing can be realized using conventional materials without the need for smart materials and can introduce foaming processes as a new external stimulus. This study highlights the potential of combining 3D printing with microcellular foaming for advanced 4D printing applications.
Simulation and Analysis of Hydrodynamic Behavior in Different Nozzles and Its Corresponding Fluidized Beds
Authors: Tian Minghang , Li Junqiang , Mo Wenlong , Jiao Kunpeng , Peng Wei , Yang Xiaoqin , Zhang Shupei
Published: August 2024

Uniform air distribution is the basic condition for the stable operation of circulating fluidized beds and closely related to the hole layout of nozzles and the air outlet conditions. In this paper, CAD modeling software is used to establish different opening types for nozzles and the corresponding gasifier models, and Fluent simulation software for numerical simulations (k-ε model) is introduced to the hydrodynamic behavior of the upper opening, the side opening and the combined opening types of nozzles, as well as the corresponding single-nozzle fluidized bed gasifiers. The flow field distribution under the above opening modes is obtained, including the velocity distribution, static pressure distribution, and total pressure distribution, and the influence of the boundary conditions, including the inlet gas velocity and outlet pressure, on the flow field distribution inside the nozzle and in the single-nozzle fluidized bed gasifier is also investigated. The simulation results show that the suitable optimal operating conditions for the coal gasifier can be achieved with an inlet velocity of 30 m/s and an outlet pressure of 25 kPaG. Under the above conditions, the local fluidization dead zone at the elbow and top of the nozzle is narrower, the uniformity of the wind velocity can be improved, the pressure drop of the inner core tube of the nozzle is gentle, and the pressure distribution tends to be stable. Theoretically, the anti-slag performance of the nozzle is improved, which will enhance the stability and reliability of the operation of the gasification unit.
Assessing the Physiochemical and Sensorial Quality of Pea Sauce Canned in Plastic Trays vs. Metal Cans
Authors: Abdelaali Hedi , Hajji Wafa , Selmi Rachid , Mallek Hana , Ben Khalifa Imen , Bellagha Sihem , Jebali Mounir , Essid Iness
Published: August 2024

Metal cans, while boasting excellent barrier properties, raise concerns about leaching and environmental impacts. This study explored plastic trays, a potential alternative for canned food packaging. First we delved into the plastic tray’s characteristics, including its composition and permeability to oxygen and water vapor. Secondly, we conducted a comparison between the newly introduced plastic packaging and traditional metal cans, focusing on their interactions with food during the sterilization process and their effects on the quality of Tunisian pea sauce. The composition analysis revealed that the plastic tray was composed of polypropylene (PP) (with a single endothermic peak at 168 °C), while the film was found to have a mixture of PP internally and polyethylene terephthalate (PET) externally (with two endothermic peaks at 161.96 °C and 243.81 °C). Plastic trays showed good results in water vapor permeability (0.832 g/m2.d) but exhibited higher oxygen permeability (190 g/m2.d), raising oxidation concerns. Migration testing confirmed plastic packaging safety (<10 mg/dm2), while some simulants exceeded limits in metal cans. pH levels remained consistent between both packaging types, but varied significantly over a 28-day storage. Total Volatile Basic Nitrogen (TVBN) levels differed significantly between plastic and metal packaging, with notable variations observed over time with maximums of 0.3 mg/100 g for plastic trays and 0.17 mg/100 g for metal cans. Sensory evaluation revealed that tasters were adept at differentiating between canned pea sauce in plastic trays and metal cans (83%, 10/12), with taste and color exhibiting significant differences (p < 0.05). This underlines the impact of packaging material on canned food quality and consumer preference, with minimal influence on other sensory aspects. This data empowers manufacturers to make informed packaging decisions for a diverse range of canned foods.
Representing Religion in North and South Korea: Seventy-Five Years of the Semiotics of Stamp Design
Authors: Grayson James H.
Published: August 2024

As government documents, postage stamps are a rich source of information about a government’s policies on a wide range of subjects. In this article, a comparative semiotic analysis of the first seventy-five years of North and South Korean stamps is used to illustrate the similarities and differences in their attitudes towards ‘religion’ and religious practice. A corpus of stamps on a ‘religious’ theme was created for stamps issued by both governments from which a series of themes and motifs was noted. The semiotic analysis of the themes and motifs showed that while on South Korean stamps Buddhist motifs constituted the majority of stamps commemorating cultural history, there were few references to the commemoration of Buddhism itself. The reverse was found to be true for Christianity. Although Christianity was not shown to be a major expression of Korean culture, Christianity itself was commemorated extensively. On North Korean stamps, folklore and Christian motifs predominated as projections of cultural history, but the Christian motifs referred only to foreign cultures, not Korean culture. Motifs relating to the foundation myth of Tan’gun were common to both North and South Korea. However, in the South, motifs from the myth referred to the nation, while in the North they referred to the ruling family.
The Impact of Research and Development Investment on the Performance of Portuguese Companies
Authors: Santos Ana , Bandeira Ana , Ramos Patrícia
Published: August 2024

This study investigates the impact of Research and Development (R&D) investment on the performance of Portuguese companies, specifically addressing the gap in understanding how R&D influences a company’s value and performance. We employ a dynamic panel data model estimated using the Generalized Method of Moments (GMM) to account for potential endogeneity issues. This approach allows us to analyze the influence of R&D investment on the Return on Operating Assets (ROA) for Portuguese companies with significant R&D investments between 2012 and 2019. The analysis reveals that while R&D investment itself may not have a statistically significant short-term impact on ROA, lagged financial performance, leverage, asset turnover ratio, and accounts payable turnover all demonstrate a statistically significant relationship with the dependent variable.
A Multi-Level Cross-Attention Image Registration Method for Visible and Infrared Small Unmanned Aerial Vehicle Targets via Image Style Transfer
Authors: Jiang Wen , Pan Hanxin , Wang Yanping , Li Yang , Lin Yun , Bi Fukun
Published: August 2024

Small UAV target detection and tracking based on cross-modality image fusion have gained widespread attention. Due to the limited feature information available from small UAVs in images, where they occupy a minimal number of pixels, the precision required for detection and tracking algorithms is particularly high in complex backgrounds. Image fusion techniques can enrich the detailed information for small UAVs, showing significant advantages under extreme lighting conditions. Image registration is a fundamental step preceding image fusion. It is essential to achieve accurate image alignment before proceeding with image fusion to prevent severe ghosting and artifacts. This paper specifically focused on the alignment of small UAV targets within infrared and visible light imagery. To address this issue, this paper proposed a cross-modality image registration network based on deep learning, which includes a structure preservation and style transformation network (SPSTN) and a multi-level cross-attention residual registration network (MCARN). Firstly, the SPSTN is employed for modality transformation, transferring the cross-modality task into a single-modality task to reduce the information discrepancy between modalities. Then, the MCARN is utilized for single-modality image registration, capable of deeply extracting and fusing features from pseudo infrared and visible images to achieve efficient registration. To validate the effectiveness of the proposed method, comprehensive experimental evaluations were conducted on the Anti-UAV dataset. The extensive evaluation results validate the superiority and universality of the cross-modality image registration framework proposed in this paper, which plays a crucial role in subsequent image fusion tasks for more effective target detection.
Driving Attention State Detection Based on GRU-EEGNet
Authors: Wu Xiaoli , Shi Changcheng , Yan Lirong
Published: August 2024

The present study utilizes the significant differences in θ, α, and β band power spectra observed in electroencephalograms (EEGs) during distracted versus focused driving. Three subtasks, visual distraction, auditory distraction, and cognitive distraction, were designed to appear randomly during driving simulations. The θ, α, and β band power spectra of the EEG signals of the four driving attention states were extracted, and SVM, EEGNet, and GRU-EEGNet models were employed for the detection of the driving attention states, respectively. Online experiments were conducted. The extraction of the θ, α, and β band power spectrum features of the EEG signals was found to be a more effective method than the extraction of the power spectrum features of the whole EEG signals for the detection of driving attention states. The driving attention state detection accuracy of the proposed GRU-EEGNet model is improved by 6.3% and 12.8% over the EEGNet model and PSD_SVM method, respectively. The EEG decoding method combining EEG features and an improved deep learning algorithm, which effectively improves the driving attention state detection accuracy, was manually and preliminarily selected based on the results of existing studies.
User Privacy Protection via Windows Registry Hooking and Runtime Encryption
Authors: Amoruso Edward L. , Leinecker Richard , Zou Cliff C.
Published: August 2024

The Windows registry contains a plethora of information in a hierarchical database. It includes system-wide settings, user preferences, installed programs, and recently accessed files and maintains timestamps that can be used to construct a detailed timeline of user activities. However, these data are unencrypted and thus vulnerable to exploitation by malicious actors who gain access to this repository. To address this security and privacy concern, we propose a novel approach that efficiently encrypts and decrypts sensitive registry data in real time. Our developed proof-of-concept program intercepts interactions between the registry’s application programming interfaces (APIs) and other Windows applications using an advanced hooking technique. This enables the proposed system to be transparent to users without requiring any changes to the operating system or installed software. Our approach also implements the data protection API (DPAPI) developed by Microsoft to securely manage each user’s encryption key. Ultimately, our research provides an enhanced security and privacy framework for the Windows registry, effectively fortifying the registry against security and privacy threats while maintaining its accessibility to legitimate users and applications.
A Survey on Sensor Failures in Autonomous Vehicles: Challenges and Solutions
Authors: Matos Francisco , Bernardino Jorge , Durães João , Cunha João
Published: August 2024

Autonomous vehicles (AVs) rely heavily on sensors to perceive their surrounding environment and then make decisions and act on them. However, these sensors have weaknesses, and are prone to failure, resulting in decision errors by vehicle controllers that pose significant challenges to their safe operation. To mitigate sensor failures, it is necessary to understand how they occur and how they affect the vehicle’s behavior so that fault-tolerant and fault-masking strategies can be applied. This survey covers 108 publications and presents an overview of the sensors used in AVs today, categorizes the sensor’s failures that can occur, such as radar interferences, ambiguities detection, or camera image failures, and provides an overview of mitigation strategies such as sensor fusion, redundancy, and sensor calibration. It also provides insights into research areas critical to improving safety in the autonomous vehicle industry, so that new or more in-depth research may emerge.
Advancing Global Pose Refinement: A Linear, Parameter-Free Model for Closed Circuits via Quaternion Interpolation
Authors: Benevides Rubens Antônio Leite , dos Santos Daniel Rodrigues , Pavan Nadisson Luis , Veiga Luis Augusto Koenig
Published: August 2024

Global pose refinement is a significant challenge within Simultaneous Localization and Mapping (SLAM) frameworks. For LIDAR-based SLAM systems, pose refinement is integral to correcting drift caused by the successive registration of 3D point clouds collected by the sensor. A divergence between the actual and calculated platform paths characterizes this error. In response to this challenge, we propose a linear, parameter-free model that uses a closed circuit for global trajectory corrections. Our model maps rotations to quaternions and uses Spherical Linear Interpolation (SLERP) for transitions between them. The intervals are established by the constraint set by the Least Squares (LS) method on rotation closure and are proportional to the circuit’s size. Translations are globally adjusted in a distinct linear phase. Additionally, we suggest a coarse-to-fine pairwise registration method, integrating Fast Global Registration and Generalized ICP with multiscale sampling and filtering. The proposed approach is tested on three varied datasets of point clouds, including Mobile Laser Scanners and Terrestrial Laser Scanners. These diverse datasets affirm the model’s effectiveness in 3D pose estimation, with substantial pose differences and efficient pose optimization in larger circuits.
Research on Automated Modeling Technology of Sluice Gate Project Based on BIM Technology
Authors: Madiniyeti Jiedeerbieke , Zhou Qiujing , Qi Huijun , Chao Yang , Zhang Yu
Published: August 2024

In order to improve the efficiency and accuracy of the modeling and design work of the sluice gate project, this paper proposes an automatic generation template of the sluice gate project with customized semantics and project layout scheme, aiming at realizing the rapid assembling of all kinds of components of the sluice gate project. In the construction process, this paper first starts from basic parametric modeling and proposes constraints as the basis of modeling. Subsequently, a template library framework is developed based on the constraints to ensure that the generated templates have a high degree of standardization and consistency. Finally, an efficient and flexible template library is successfully constructed by using the customized classes and functions of Revit API, which provides powerful technical support for the modeling and design work of sluice gate engineering. This achievement helps to promote the informationization and intelligent development of the water conservancy engineering industry, and its versatility and scalability also make it have a wide range of application prospects in other water conservancy engineering fields.