bluuebunny/crossref_metadata_2025 huggingface dataset:
Automatic estimation of the number of minimal language units by articulation
Authors:   Saint Petersburg State University of Aerospace Instrumentation, Yachnaya V.O. ,   Pavlov Institute of Physiology, Russian Academy of Sciences, Lutsiv V.R. ,   Saint Petersburg State University of Aerospace Instrumentation
Published: January 2025

The presented work is dedicated to the automatic analysis of the paraverbal component of human communication. The article describes systems that determine the number of minimal linguistic units (syllables and phonemes) in spoken language based on video data. Such systems can be used to assess the subject speech rate, which can be applied in the preclinical diagnosis of certain pathological conditions or determining emotional status. To conduct the research, an existing database of English words was modified, and annotations containing information on the number of syllables and phonemes in each word were obtained. During the study, a word recognition system was adapted to solve the stated task, and a new neural network architecture to determine the number of syllables and phonemes in a word was designed. The effectiveness of the developed systems was assessed on both sets of previously known to the systems words and on new words. As a result of the research, a system that determines the number of minimal language units in a spoken word was obtained, providing the opportunity for subsequent assessment of the subject articulation rate.
Attention modules in convolutional neural networks for small object recognition
Authors:   ITMO University, Krasnov D.I.
Published: January 2025

A problem of small object recognition is frequently encountered in biomedical and security systems. However, the detection of such objects is often complicated by presence of dense clouds or infrastructure objects. Results of using various attention mechanisms to improve accuracy in small objects segmentation with convolutional neural networks are presented in this paper. Modules of channel attention and spatial attention are considered. This approach allows one to effectively suppress less informative channels and image areas, while enhancing more informative channels and image areas. Meanwhile, weights of the attention modules are automatically adapted to the input data during training. An assessment of influence of the attention mechanisms in convolutional neural network architecture on the ability to suppress complex backgrounds (clouds and infrastructure objects) and segment small objects is performed. The results are presented in the form of tables with test metrics and figures with precision-recall curves, ROC curves and heatmaps showing an effectiveness of background suppression. The results obtained allow one to implement the described attention modules in the convolutional neural networks of any complexity and increase the recognition accuracy of objects of 10-40 pixels in size on a complex background.
Mathematical modeling of processes in quantum computer elements based on methods of quantum theory to improve their efficiency
Authors:   Samara State Transport University, Biryukov A.A. , Shleenkov M.A. ,   Samara National Research University
Published: January 2025

The paper studies entangled states of two qubits interacting with each other and with an electromagnetic field. The state of the qubits is determined by a statistical density matrix. The degree of entanglement of the state is characterized by the Peres-Gorodeckii (PG) parameter. The statistical density matrix and its evolution are determined in the energy representation within the framework of the path integral formalism. The obtained equations determine the dependence of the PG parameter on the parameters of qubit dipole-dipole interaction and the acting electromagnetic field. The results of numerical calculations are presented in graphs for the PG parameter. It is shown that it is possible to choose parameters corresponding to qubit states with a high degree of entanglement (0.99).
Superposition of an optical vortex and a plane wave with linear polarization states at the tight focus
Authors:   Image Processing Systems Institute, NRC "Kurchatov Institute", Kotlyar V.V. ,   Samara National Research University, Stafeev S.S. ,   Image Processing Systems Institute, NRC "Kurchatov Institute",   Samara National Research University, Telegin M.A. ,   Image Processing Systems Institute, NRC "Kurchatov Institute",   Samara National Research University, Kozlova E.S. ,   Image Processing Systems Institute, NRC "Kurchatov Institute",   Samara National Research University
Published: January 2025

We analyze the sharp focusing of the superposition of a vortex laser beam with topological charge n and linear polarization and a plane wave with the same linear polarization directed along the horizontal axis. Using the Richards-Wolf formalism, analytical expressions are obtained for the intensity distribution and longitudinal projection of the spin angular momentum (SAM) in the focal plane. It is shown that for even and odd numbers n the intensity and SAM have different symmetries: for even n they are symmetric with respect to both Cartesian axes, and for odd n they are symmetric only with respect to the vertical axis. The intensity distribution has 2n local maxima at the focus, and the intensity on the optical axis is nonzero for any n. The distribution of the longitudinal SAM (spin density) in the focal plane has (n+2) subwavelength regions with a positive SAM and (n+2) regions with a negative SAM, the centers of which alternately locate on a circle of a certain radius centered at the optical axis. Such an alternating-spin pattern demonstrates the spin Hall effect at the focus. At the focus, the negative and positive spins are mutually compensated, meaning that the total spin is zero.
Semi-Quantitative Method of Immunohistochemical Evaluation of the PDCD4 Regulatory Protein to Study its Role in Carcinogenesis
Authors: Rubtsov V. A. , Parygina M. N. , Pomorgailo E. G. , Shimanskaya A. G. , Mozgovoi S. I. , Kononov A. V.
Published: January 2025

The participation of PDCD4 protein in molecular mechanisms of key importance in carcinogenesis makes the assessment of the level of its synthesis in tissues important for assessing the early diagnosis of malignant tumors. The aim of the presented study was to develop a method for evaluation of the results of immunohistochemical staining of the PDCD4 protein. Material and methods. The material for the study included 49 samples of human gastric adenocarcinoma tissue and 80 cases of endoscopic biopsy examination of the gastric mucosa of patients with dyspeptic complaints. Morphological changes in biopsies corresponded to chronic gastritis with varying degrees of inflammation. Rabbit monoclonal anti-PDCD4 antibodies (clone EP 102, abcam, USA) and a detection system (Diagnostic BioSystems, USA) were used to detect PDCD4 protein by immunohistochemical method. Results. The developed can be used for semi-quantitative visual assessment of synthesis of regulatory protein PDCD4 in histological sections of tissue by immunohistochemical method with detection in nucleus and cytoplasma. That is ensured by calculating an expression index of PDCD4 in tissues when summing up the nuclei expression and cytoplasm expression. Nuclear expression represents a product of staining frequency of nuclei (0–3 points) and semi-quantitative visual assessment of intensity of coloring nuclei (0–3 points). Cytoplasmic expression represents semi-quantitative visual assessment of intensity of cytoplasm (0–3 points). Conclusion. The proposed method makes it possible to evaluate the synthesis of the PDCD4 regulatory protein in tissues with greater sensitivity and specificity, which makes it possible to detect a violation of PDCD4 expression in epithelial cells at the early stages of tumor cell transformation.
Kinetic evaluation of ultrasound and microwave pretreatments for flavonoids (pinocembrin and galangin) extraction from the residual bagasse of Mexican oregano (Lippia graveolens Kunth).
Authors: Cuevas González María Fernanda , Flores Martínez Héctor , Mancilla Margalli Norma Alejandra , Padilla de la Rosa José Daniel , López Muraira Irma Guadalupe , Gómez Leyva Juan Florencio
Published: January 2025

The essential oil profile of Mexican oregano (Lippia graveolens Kunth) makes it a spice with significant economic potential. However, its high concentration of compounds water-soluble phenolic (pinocembrin and galangin), flavonoids with important therapeutic properties little used. The content of these flavonoids remains in significant quantities in the residual bagasse obtained after the essential oil extraction process. This bagasse, being rarely used and due to its inadequate disposal, represents a source of contamination. This research focused on taking advantage of the residual bagasse, extracting the flavonoid compounds (pinocembrin and galangin) evaluated by HPLC-DAD. As extraction pretreatments, the use of ultrasound and microwaves at different powers was evaluated, followed by extraction with agitated maceration. The extraction kinetics could be adjusted to a second-order model, revealing a two-stage extraction process: diffusion and washing. The maximum extraction capacity (Cs) and recovery of pinocembrin and galangin were obtained using ultrasound at 325W for 5 minutes, reducing the total extraction time by 59%. The total phenolic content (Folin-Ciocalteu) and antioxidant capacity (ORAC, DPPH and FRAP) of the extracts obtained were evaluated. This approach represents an alternative use of residual bagasse and a significant improvement in the efficiency of the conventional extractive process.
Effects of a new GABA derivative with anxiolytic and antidepressant actions on sexual behavior, fertility, and the development of products of conception
Authors: Lavrova Elena B. , Kuzubova Elena A. , Bugaeva Lyubov I. , Tyurenkov Ivan N. , Maltsev Mikhail V. , Kuzubov Alexander V.
Published: January 2025

In experiments on adult rats, females studied the effect of a new derivative of GABA – citrocard (citrate of 4-amino-3-phenylbutanoic acid) on sexual behavior and fertility. Citrocard in doses of 50 mg/kg (experimentally proven therapeutic dose) and 700 mg/kg (dose exceeding the therapeutic 14 times) was administered intragastrically to female rats for 2 weeks. It was established that after the introduction of sexual behavior in rats of females receiving a citrocard at a dose of 50 mg/kg, the duration of sexual activity did not change relative to the control, but the ability to mate with males was clearly increased (“emotional” approaches and lordoses increased by 43,8 % (p 0.01) and 30.4 % (p 0.05)), respectively. In females treated with a citrocard at a dose of 700 mg/kg, the duration of sexual activity decreased slightly, but their receptive ability was higher than the control values (the number of lordoses indicating their readiness for mating increased by 17.4 % (p 0,05). It was also revealed that when mating with intact males in rats of females previously treated with a citrocard 2-week course, fertility processes and fertility rates increased. Relative to control, in females of the experimental groups, the pregnancy index increased, by 4.8% (p 0.05) and 33.3 % (p 0.05), respectively, in doses and fertility, by 4.2% (p 0 05) and 19.0% (p 0.05), as well as their overall fetal death rates decreased, both preimplantation and postimplantation.
Rhabdomyolysis clinical case, complicated by acute renal injury
Authors: Statsenko Mikhail E. , Statsenko Igor Yu. , Statsenko Yuri I. , Skvortsov Vsevolod V. , Sergeev Vladimir S.
Published: January 2025

Тhis article is devoted to the issues of etiology, pathogenesis, classification, description of the clinical picture, approaches to the diagnosis and treatment of such a clinical and laboratory syndrome as rhabdomyolysis. For a detailed acquaintance with this nosology, we provide an analysis of a clinical case, where we tried to set out in detail the main aspects and key points of a timely and correct diagnosis, as well as possible examples of diagnostic treatment. The given clinical example allows us to trace the development of the disease in a particular case, the possibilities of modern research methods in the diagnosis of this pathology, as well as to evaluate the effectiveness of the therapy.
Method for determining atrophy of alveolar arches and the frequency of occurrence of their main variants in the complete absence of teeth
Authors: Shkarin V. V. , Yukhnov I. N. , Dmitrienko T. D.
Published: January 2025

Methods of prosthetic treatment in the complete absence of teeth are determined by the severity of atrophy of the alveolar arches, which differ in a variety of forms. Purpose. To develop a method for determining the degree of alveolar arch atrophy and to determine the frequency of occurrence of various variants in the clinic of prosthetic dentistry. Material and methods. A two-stage cahort study included the analysis of the transversal dimensions of the dentofacial arches at the level of the second molars, which made it possible to measure tomograms in different parts of the apical basis (cervical, root, apical). The second stage of the study was carried out on models with complete edentulism. Outcomes. In the upper jaw, the cervical transversal, compared to the root transversal, was larger by (3.01 ± 0.03) mm and (6.1 ± 0.07) mm larger than the apical transversal. In the lower jaw, the cervical transversal, in comparison with the root transversal, was (3.26 ± 0.05) mm smaller and (5.96 ± 1.07) mm smaller than the interapical transversal. Conclusion. A difference in the size of the posterior alveolar width of up to three millimeters is characteristic of first-degree atrophy. A difference in the size of the posterior alveolar width of four to eight millimeters is characteristic of second-degree atrophy, and a difference of more than nine millimeters is considered to be marked third-degree atrophy of the distal alveolar arches. These differences are applicable in the clinic of prosthetic dentistry when choosing methods for modeling artificial dental arches in full removable dentures, as well as for assessing the effectiveness of treatment.
Comparative characteristics of microbiota in puropental-inflammatory diseases of the maxillofacial area in children
Authors: Khalyuta Elena E. , Mokhnacheva Svetlana B. , Pestryakova Ksenia V. , Kutliarova Adelina R. , Loshchilova Ksenia A.
Published: January 2025

Purpose: Determination and comparison of the properties of the microbiota of purulent foci in inflammatory processes of the jaws, acute purulent lymphadenitis, adenophlegmons, boils of the maxillofacial area in children.
Materials and methods: A sample of 1176 medical records of inpatients was studied. Microbiological research methods were used, including: microscopic, cultural methods and determination of the sensitivity of the isolated pathogen.
Results: Streptococcus pyogenes was identified in inflammatory processes of the jaws in 65.6 %; for acute purulent lymphadenitis – in 14.3 %, for boils – in 9.04 %. Staphylococcus aureus was recorded with boils in 82.53 %, with acute purulent lymphadenitis in 38.1 %; with inflammatory processes of the jaws in 2.8 %. The greatest sensitivity of Streptococcus pyogenes in acute inflammatory processes of the jaws and boils was noted to vancomycin (99–100 %), fluoroquinolones (93.3–98 %), beta-lactams (86.6–91 %); for purulent lymphadenitis – to beta-lactams (100 %); the greatest sensitivity of Staphylococcus aureus in acute inflammatory processes of the jaws was noted to aminoglycosides, fluoroquinolones (96 %), for boils – to aminoglycosides (96.2 %), beta-lactams (94. 3 %), linezolid (93.3 %); for lymphadenitis – to beta-lactams (83 %).
Conclusion: In purulent-inflammatory diseases of the jaws in childhood, the leading pathogen was Streptococcus pyogenes with a high level of sensitivity to vancomycin, fluoroquinolones, and beta-lactams; for purulent-inflammatory diseases of soft tissues – Staphylococcus aureus with a high level of sensitivity to aminoglycosides and beta-lactams.
Editorial v. 26
Authors: Dias Júnior Antonio Carlos , Garbin Mônica Cristina
Published: January 2025

Editorial referente ao número 26 da Revista.
Codificando saberes
Authors: Ceratti Magdalena Dal Ponte , Nóbile Márcia Finimundi
Published: January 2025

O presente artigo descreve um relato de experiência de aplicação de oficinas de Scratch nas aulas de Ciências, proporcionada a uma turma de 15 estudantes do 6º ano do Ensino Fundamental de uma escola pública do município de Farroupilha/RS, visando estimular o Pensamento Computacional (PC). Utilizou-se uma metodologia qualitativa, observações, criação de repositório de projetos e aplicação de questionário aos participantes. As atividades práticas foram projetadas para proporcionar uma abordagem dinâmica e interativa, promovendo a conexão entre conceitos científicos e habilidades de programação. Observou-se um impacto positivo, não apenas no desenvolvimento do Pensamento Computacional, mas também na compreensão mais profunda dos temas científicos abordados. Ao fim do estudo, conclui-se que a utilização de Scratch enriqueceu a experiência do processo de ensino e aprendizagem em Ciências, revelando-se uma ferramenta pedagógica eficaz ao mesmo tempo que promoveu o PC através da programação.
Various methods affect the flexural strength of repairing the denture base
Authors: Alfahdawi Ibrahim H.
Published: January 2025

Background: The assembly of replacement teeth to mimic natural ones remains a challenge for dentists, particularly regarding the surface characteristics of prosthetic teeth. Purpose: To evaluate various surface mechanical techniques that affect the flexural stress of a repaired denture base. Methods: Six sets (n = 10) of sixty heat-polymerized acrylic resin bar-shaped samples have been produced. Samples were divided into halves to give a 1-mm clearance, with the exception of the group under positive control (group PC). Also taken into account was a negative control group (group NC) that received no skin treatment. Other groups received a variety of surface treatments, including group Er:YAG laser therapy, group abrasion by airborne particles (APA), group APA + Laser, and group Bur grinding. All sectioned samples were repaired by auto-polymerizing acrylic resin, which was then thermocycled after surface roughness was measured with a profilometer. A global testing device conducted a three-point bending test. Results: The mean surface roughness of all study groups was considerably greater than group NC's (P<0.05). With the exception of group Bur, group PC's flexural strength was considerably greater than that of all other groups (P=0.999). The bending strength of groups Bur and Laser among all surface-treated groups was significantly greater than that of group NC (P=0.001 and P=0.015, respectively). Conclusion: All surface treatments enhanced surface roughness in comparison to the untreated group, but bur grinding and Er:YAG laser exposure also significantly raised the flexural strength of the sectioned groups. Sectioned polymethyl methacrylate’s flexural strength was significantly increased by bur grinding.
Dental students’ perception of a self-preference musical mobile app used as a relaxing tool in the clinical setting
Authors: Zarudin Nur Irdina Nasmi , Ismail Syamim Illya , Rajali Aiemeeza , Nik Zulkifeli Nik Rahayyu , Ahmad Mas Suryalis , Mustafa Nor Wati Nur Atikah
Published: January 2025

Background: Diverse music activities may reduce stress and enhance well-being. However, using a musical mobile health application (app) as an intervention during dental treatment has not yet been established. Hence, a self-preference musical mobile app (ACOU@PLAY) has been created for use in clinical settings. Purpose: This study aims to assess the quality of the ACOU@PLAY app as a relaxing tool for dental students and compare the results with patients’ opinions. Methods: A total of 53% (n = 38) dental students and 47% (n = 35) patients were recruited to use the self-preference musical mobile app (ACOU@PLAY) for 10 minutes and watch a 5-minute pre-recorded video. Then, an evaluation was performed using a validated tool, the modified user version Mobile App Rating Skill (uMARS), which included a demographic survey. The uMARS questionnaire consists of five domains (engagement, functionality, aesthetics, information, and app subjective quality) using a 5-point Likert scale. Results: The average quality score of the app was 3.96 ± 0.509. The app received its highest rating for the information domains, with a mean score of 4.14 ± 0.577, and its lowest for subjective quality, with a mean score of 3.63 ± 0.565. Notable differences were observed in the ratings for engagement (p = 0.008) and aesthetics (p = 0.035) between dental students and patients, as well as significant differences in ratings based on gender in the domains of engagement (p = 0.007), functionality (p = 0.018), and aesthetics (p = 0.021). Conclusion: The self-preference musical mobile app (ACOU@PLAY) is well accepted by dental students and favored by patients with adequate qualities to be used in clinical settings.
Effect of cocoa pod husk (Theobroma cacao L.) extract on alveolar socket post tooth extraction
Authors: Rahayu Yani Corvianindya , Yuwono Budi , Syafriadi Mei , Amin Muhammad Nurul , Kumala Efa Ayu Ratnaning
Published: January 2025

Background: Cocoa pod husk (CPH) of Theobroma cacao L. contains tannins, alkaloids, saponins, and flavonoids triterpenoids that have antibacterial, anti-inflammatory, and antioxidant activities that can accelerate wound healing and alveolar bone regeneration. Purpose: This study aimed to analyze the effect of CPH extract gel on the number of fibroblasts, osteoblasts, and osteoclasts in Wistar rats’ sockets after tooth extraction.  Methods: The samples used were 36 male Wistar rats divided into three groups: the negative control group (placebo gel), the positive control group (Alveogyl; Septodont, UK), and the treatment group (100 mg/ml CPH extract gel), which in each application was given for three, seven, and fourteen days on the mandibular first molar post-extraction socket. The samples were sacrificed and tissue was processed on days 4, 8, and 15. The amount of fibroblasts, osteoblasts, and osteoclasts was identified and determined by the Image J software. Results: The Mann-Whitney U analysis showed significant differences (p<0.05) between groups. Fibroblasts and osteoblasts in the treatment group were significantly higher than the control groups. Osteoclasts in the treatment group were significantly lower than the control group. Conclusion: Ethanol extract gel of CPH significantly increased fibroblasts on days 3 and 5 and osteoblasts on days 7 and 14 and decreased osteoclasts on day 14 in post-extraction socket of Wistar rats.
Cervical vertebral maturation stage and Demirjian index for assessment of skeletal and dental maturation for children’s growth stages
Authors: Pradopo Seno , Nuraini Prawati , Rahmawati Luluk , Ibrahim Zurairah
Published: January 2025

Background: Determining age is essential in various fields, particularly pediatric dentistry. A reliable method for assessing an individual's growth and development involves evaluating their chronological and biological age. Biological age can be determined by examining skeletal or dental maturation. Accurately assessing growth potential and timing of growth spurts is crucial for several clinical situations, especially in the planning and outcomes of treatments like orthodontic therapy. Purpose: This study uses common radiographic ortho-diagnosis techniques to analyze the accuracy of cervical vertebral maturation stages (CVMS) and the Demirjian index methods in evaluating children's growth and development stages. Methods: The CVMS assessment on cephalometric radiography was conducted using the Bacetti method, which includes six stages. In addition, the mandibular second molars' calcification stages were evaluated using the Demirjian index method, which encompasses stages A to H on panoramic radiography. Following this, skeletal and dental maturation accuracy was analyzed using the Statistical Package for Social Sciences application. Results: This study revealed differences in the chronological age corresponding to each stage of calcification of the mandibular second molars and the CVMS. Additionally, CVMS was found to be the most accurate method for assessing age in children. Furthermore, the right side was generally preferred over the left at the calcification stages of the mandibular second molars. Conclusion: Using CVMS to assess skeletal maturation provides a more accurate determination of growth and developmental stages in children than the Demirjian index.
Fungistatic effect of Gracilaria verrucosa on phospholipase enzymes and the cell surface hydrophobicity of Candida albicans
Authors: Gani Basri A. , Andayani Ridha , Batubara Fitri Yunita , Ifwandi Ifwandi , Syafriza Dharli , Herlambang Muhammad Mas'ud , Fathirah Shiti Alya , Rifki Ayudia
Published: January 2025

Background: Candida albicans (C. albicans) was reported as a primary cause of oral candidiasis. Phospholipase enzymes and cell surface hydrophobicity (CSH) are involved in the pathogenesis of its infection. Gracilaria verrucosa (G. verrucosa) is reported to contain flavonoids, tannins, and phenolic compounds, which can inhibit the development of C. albicans. Purpose: The study analyzed the effect of the ethanol extract of G. verrucosa on the inhibition of the phospholipase enzyme and CSH of C. albicans. Methods: The G. verrucosa chemical compounds were examined by phytochemical tests and phospholipase enzyme-inhibiting egg yolk media, and a CSH assay was conducted using xylene. Results: Gracilaria verrucosa contains steroids, terpenoids, tannins/phenolics, and flavonoids. The 25%–100% concentrations inhibit the phospholipase enzyme of C. albicans more strongly at 48 hours than at 12 hours and 24 hours (p < 0.05). Furthermore, the 100% and 75% concentrations substantially affect the inhibition of CSH of C. albicans, with a strong relationship. Conclusion: Gracilaria verrucosa has a more substantial inhibitory effect in suppressing the phospholipase enzyme and CSH of C. albicans.
The role of circular RNAs in glucose metabolic reprogramming: impact on cancer progression and therapeutic implications in breast cancer
Authors: Liang Yiran , Yang Qifeng
Published: January 2025

Breast cancer is one of the most common female malignant tumors, which seriously endangers human health. Glucose metabolic reprogramming in rapidly proliferating cancers drives increased glycolysis to meet energy needs, promoting tumor growth, acidifying the tumor microenvironment, and impairing immune function, which diminishes therapeutic efficacy. Circular RNAs (circRNAs), as key regulators of cellular processes, are increasingly recognized for their involvement in the metabolic reprogramming of cancer. Concurrently, specific circRNAs could be released by tumor cells via exosomes to facilitate intercellular communication, significantly impacting glucose metabolism, cancer progression, and therapy resistance. However, the role of circRNAs in breast cancer and their mechanisms in regulating glucose metabolism remain unclear. Therefore, elucidating these metabolic regulatory pathways could provide valuable insights for developing targeted strategies to exploit metabolic vulnerabilities and improve the prognosis of breast cancer.
Expression characteristics, immune signatures, and prognostic value of the KIF family members identified across cancers
Authors: Zhang Xuewei , Zhang Yawei , Zheng Guoxing , Yang Ronghua
Published: January 2025

Aim: The overexpression of Kinesin superfamily proteins (KIFs) has been increasingly recognized as a critical factor associated with unfavorable prognostic outcomes across a spectrum of cancers. This study aims to elucidate the multifaceted role of KIFs within the tumor immune microenvironment and explore their potential as targets for precision cancer therapy.

Methods: Utilizing comprehensive genomic datasets from the Cancer Genome Atlas and Genotype-Tissue Expression databases, we systematically analyzed KIF expression patterns and their potential oncogenic functions. To investigate the functional impact of KIF3A in hepatocellular carcinoma (HCC), we synthesized siKIF3A and transfected it into HepG2 cells, followed by a series of functional assays. Cell proliferation was meticulously evaluated using EdU incorporation, CCK8, and colony formation assays, while cell migration was assessed through scratch wound healing and Transwell migration assays. Quantitative analysis of gene and protein expression levels was performed using RT-PCR and Western blot techniques, respectively.

Results: Our findings reveal that KIFs exhibit remarkably high mutation frequencies across multiple cancer types. Furthermore, we identified significant genomic and epigenetic modifications of KIFs in various tumors, with specific oncogenic mutations in certain cancers potentially serving as regulatory mechanisms for KIFs expression. Notably, tumor-derived KIFs demonstrate a strong association with immune cell infiltration patterns, suggesting their potential as novel therapeutic targets in cancer immunotherapy. Importantly, the majority of KIF family genes show significant correlations with patient prognosis, underscoring their clinical relevance. Specifically, KIF3A emerges as a promising prognostic marker for HCC, demonstrating significantly higher expression levels in HCC tissues compared to adjacent non-cancerous tissues (P < 0.05). This overexpression strongly correlates with poor survival outcomes and established risk factors. Functional studies reveal that knockdown of KIF3A significantly inhibits the proliferation and migration capabilities of HCC cells (P < 0.05), highlighting its critical role in tumor progression. Our findings suggest that KIF3A not only serves as a valuable prognostic biomarker but also represents a potential therapeutic target for HCC patients, particularly through its involvement in tumor immune regulation mechanisms.

Conclusion: This comprehensive study provides novel insights into the role of KIFs, particularly KIF3A, in cancer biology and offers promising avenues for the development of targeted therapies in hepatocellular carcinoma. The integration of genomic analysis with functional validation underscores the potential of KIFs as both diagnostic markers and therapeutic targets in cancer management.
PERBEDAAN UKURAN GIGI MOLAR PERTAMA MAKSILA DAN KANINUS MANDIBULA PERMANEN ANTARA MAHASISWA LAKI-LAKI DAN PEREMPUAN (Tinjauan pada Mahasiswa PSKG Suku Banjar)
Authors: Rahmah Siti Aulia , Sukmana Bayu Indra , D.H Irnamanda
Published: January 2025

ABSTRACTBackground: Natural disasters occur frequently in Indonesia. Gender identification is one of the important things in determining the identity of the victim. Gender can be identified based on the size of the teeth. Differences in tooth size are caused by differences in gender and race. Objective: To determine mean difference in the size of maxillary first molar teeth and mandibular caninus between males and females in Banjar tribe PSKG students. Methods This research is a analytic observational method. This study used 40 male and 40 female dental models that measured the mesiodistal and buccolingual width of the maxillary first molar and mandibular canine teeth using digital caliper. Results: The results of the normality test of normally distributed data, followed by an independent t-test, obtained a p value = 0.0001 <0.05 which shows that the hypothesis is accepted or there is a significant difference in the size of the mesiodistal and buccolingual teeth in the maxillary first molar and mandibular canine between male and female students of the Banjar tribe. Conclusion: There is a difference in the mesiodistal and buccolingual means of maxillary first molar and mandibular canine teeth between males and females in Banjar tribe PSKG students.Keywords: Sex identification, tooth size, mesiodistal, buccolingual, maxillary first molar, mandibular caninus ABSTRAKLatar Belakang : Bencana alam sering terjadi di Indonesia. Identifikasi jenis kelamin adalah salah satu hal penting dalam menentukan identitas korban. Jenis kelamin dapat diidentifikasi berdasarkan ukuran gigi geligi. Perbedaan ukuran gigi disebabkan oleh adanya perbedaan jenis kelamin dan ras. Tujuan: Untuk mengetahui perbedaan rerata ukuran gigi molar pertama maksila dan kaninus mandibula antara laki-laki dan perempuan pada mahasiswa PSKG suku Banjar. Metode: Penelitian ini merupakan metode observasional analitik. Penelitian ini menggunakan 40 model gigi laki-laki dan 40 model gigi perempuan yang diukur lebar mesiodistal dan bukolingual gigi molar pertama maksila dan kaninus mandibula menggunakan kaliper digital. Hasil: Hasil uji normalitas data berdistribusi normal, dilanjutkan dengan uji t-test independent didapatkan nilai p=0.0001<0.05 yang menunjukkan hipotesis diterima atau terdapat perbedaan signifikan ukuran gigi mesiodistal dan bukolingual pada gigi molar pertama maksila dan kaninus mandibula antara mahasiswa laki-laki dan perempuan suku Banjar. Kesimpulan: Terdapat perbedaan rerata ukuran gigi mesiodistal dan bukolingual pada gigi molar pertama maksila dan kaninus mandibula antara laki-laki dan perempuan pada mahasiswa PSKG suku Banjar. Kata kunci: Kaninus Mandibula, Bukolingual, Mesiodistal, Maksila, Jenis Kelamin, Ukuran Gigi.
THE RELATIONSHIP BETWEEN PARENTING PATTERN AND THE PERFORMANCE TREATMENT INDEX (PTI)
Authors: Noormazidah Sity , Hatta Isnur , Wibowo Diana , Wardani Ika Kusuma , Sari Galuh Dwinta
Published: January 2025

Background: Parent parenting is a way of parents in making a series of positive efforts in educating and developing their children. Parental parenting patterns have three: democratic (authoritative), authoritarian (authoritarian) and permissive. Good parenting patterns affect the actions of people in maintaining their fixed teeth called Performance Treatment Index (PTI) which is the percentage of the number of fixed teeth carried out by a shed or patching of the DMF-T number. The percentage of damaged, perforated and painful teeth in Banjar Regency ranks eleven, namely 43.34% and the percentage of patched teeth / dens is 5.65% this is the third lowest among the districts in South Kalimantan. Purpose: Analyzing parental parental pattern relationships with Performance Treatment Index (PTI) in MTsN 1 Banjar District Gambut Banjar Regency. Methods: This research is by observational analytics method with cross-sectional approach. The sampling technique uses simple random sampling with a sample number of 36 people research. Test the analysis using SPSS application by Spearman method. Results: The results show that most parents apply democratic (authoritative) parenting patterns. Performance Treatment Index (PTI) students are considered bad, and not obtained parents with authoritarian parenting (authoritarian) parenting patterns. Spearman test results showed no connection between parenting patterns and Performance Treatment Index (PTI) students (p value = 0.320). Conclusion: The parenting patterns applied by parents are more democratic (authoritative) types and there is no connection between parenting patterns and Performance Treatment Index (PTI).
DIFFERENCES IN THE EFFECTIVENESS OF DENTAL HEALTH EDUCATION USING SONGS AND POSTERS ON TOOTH BRUSHING KNOWLEDGE
Authors: Aqsha Syahari Sabila Maghfuroh , Hatta Isnur , Sari Galuh Dwinta , Wibowo Diana , Adhani Rosihan
Published: January 2025

Background: Based on Riskesdas (2018), the largest proportion of dental problems in Indonesia are damaged teeth/cavities/toothache, one of the reasons is the low proportion of tooth brushing behavior. Banjarbaru City is the area with the lowest prevalence in the South Kalimantan region in the right time to brush teeth with the proportion is only 2,06%. Bloom divided behavior into 3 domains, namely knowledge, attitudes, and actions. One of the efforts to increase knowledge maintaining oral health can be through Dental Health Education used songs and posters. Purpose: Analyzing the differences in the effectiveness of Dental Health Education using the Healthy Teeth song and the Read Me poster on increasing knowledge of brushing teeth of class VI students at SDN 2 Loktabat Selatan. Methods: used a quasi-experimental design method with a non-equivalent control group design. Sampling technique used was total sampling technique. The research was conducted at SDN 2 Loktabat Selatan with a sample of 79 respondents. Results: Wilcoxon showed that there were differences in knowledge of brushing teeth before and after DHE using the Healthy Teeth song and Read Me posters in the intervention group (p=0,000) and there was no difference in knowledge of brushing teeth between pretest and posttest in the control group (p=0,809). Mann Whitney showed that there were differences in knowledge of brushing teeth between the song and poster groups (p=0,001), but the mean rank of the song group was higher. Conclusion: DHE using the Healthy Teeth song was more effective in increasing knowledge of brushing teeth.
INOVASI MEDIA PEMBELAJARAN CANVA BERORIENTASI AUTHENTIC LEARNING PADA TOPIK GETARAN DAN GELOMBANG
Authors: Munir M. Jiddan Mishbahul , Zaini Muhammad , Haryanti Ninis Hadi , Suyidno Suyidno , Fahmi Fahmi
Published: January 2025

Media pembelajaran dengan konten yang relevan berperan penting dalam memudahkan peserta didik untuk memahami informasi secara lebih bermakna. Tujuan riset ini adalah untuk mendeskripsikan validitas media pembelajaran Canva berorientasi authentic learning pada topik getaran dan gelombang. Penelitian dan pengembangan ini menggunakan model ADDIE. Data diperoleh dari penilaian tiga validator menggunakan instrumen lembar validasi media pembelajaran yang ditinjau berdasarkan aspek media dan materi. Hasil validitas pada aspek media diperoleh skor rata-rata 3,71 dengan kategori sangat baik. Adapun validitas pada aspek materi diperoleh skor rata-rata 3,82 dengan kategori sangat baik. Dengan demikian, media pembelajaran Canva berorientasi authentic learning pada topik getaran dan gelombang dapat diujicobakan lebih lanjut dalam proses pembelajaran.
OPTIMALISASI PENILAIAN DIRI DAN SEJAWAT DALAM MENINGKATKAN KEMAMPUAN MENDESAIN MODUL AJAR BAGI MAHASISWA CALON GURU FISIKA
Authors: Zainuddin Zainuddin , Salam Abdul , Miriam Sarah , Saifuddin Anwar Rahmat , Al Farej Ansari Rahmat , Khairiyah Nor
Published: January 2025

Proses penyederhanaan Rencana Pelaksanaan Pembelajaran ke dalam bentuk modul ajar dalam implementasi kurikulum merdeka di sekolah masih menimbulkan banyak kendala di lapangan. Kendala ini juga dirasakan oleh mahasiswa calon guru ketika menjalani praktik mengajar di sekolah. Penelitian ini bertujuan untuk mengatasi permasalahan yang muncul sehubungan dengan pengembangan modul ajar dengan mengoptimalkan metode self dan peer assessment bagi mahasiswa calon guru fisika. Penelitian ini melibatkan seluruh mahasiswa pendidikan fisika dari Universitas Lambung Mangkurat (ULM) yang mengikuti program Asistensi Mengajar pada tahun 2023. Data penelitian diambil dari portofolio modul ajar yang dibuat oleh mahasiswa selama pelaksanaan asistensi mengajar, termasuk hasil karya mereka setelah menerapkan self dan peer assessment. Hasil analisis menunjukkan peningkatan yang signifikan dalam kemampuan mahasiswa merancang modul ajar, dengan rata-rata awal sebesar 62,0 meningkat menjadi 82,8. Jika dinyatakan dalam gain score, peningkatannya adalah sebesar 0,52 (berkategori sedang). Penelitian ini memberikan kontribusi dalam upaya terus-menerus untuk menyempurnakan implementasi Kurikulum Merdeka dan meningkatkan keterampilan pedagogis para calon pendidik Fisika, serta memberikan kontribusi berharga dalam bidang pendidikan.
Kata kunci: Mahasiswa Calon Guru Fisika, Modul Ajar, Penilaian Diri dan Sejawat.
 
Simplifying the Lesson Plans into Teaching Modules within implementing the Merdeka Curriculum in schools continues to encounter various challenges. Student teachers also experience these challenges during their teaching practice. This research aims to address the issues arising from the development of teaching modules by optimizing the methods of self and peer assessment for prospective Physics teachers. The study involves all Physics Education students from Universitas Lambung Mangkurat (ULM) participating in the Teaching Assistance program in 2023. Research data is derived from teaching module portfolios created by students during the teaching assistance period, including their work after implementing self and peer assessment. The analysis reveals a significant improvement in students' ability to design teaching modules, with an initial average score of 62.0, increasing to 82.8. Expressed as a gain score, this represents an improvement of 0.52 (categorized as moderate). This research contributes to the ongoing efforts to refine the implementation of the Merdeka Curriculum and enhance the pedagogical skills of future Physics educators, providing valuable insights into the field of education.
Keywords: Physics Teacher Candidates, Teaching Module, Self and Peer Assessment.
E-MODUL IPA BERBASIS AUTHENTIC LEARNING UNTUK MENINGKATKAN LITERASI DIGITAL PESERTA DIDIK
Authors: Kurniasih Tintin , Suryajaya Suryajaya , Suyidno Suyidno , Fahmi Fahmi
Published: January 2025

E-modul yang dikembangkan didasari oleh kebutuhan akan materi yang sesuai untuk pembelajaran abad 21 berbasis penggunaan teknologi informasi dan komunikasi. Model pengambangan ADDIE digunakan pada penelitian ini dengan uji coba menggunakan pre-test post-test design. Subyek uji coba adalah 50 peserta didik kelas VIII SMPN 14 Banjarmasin. Keberhasilan penelitian e-modul dinilai dari nilai kevalidan, kepraktisan, dan keefektifan untuk mengukur kelayakan e-modul yang dikembangkan. Modul yang dikembangkan dikategorikan layak digunakan dengan beberapa kriteria berikut; (1) e-modul IPA termasuk valid karena hasil validasi memenuhi kategori sangat valid; (2) e-modul IPA termasuk praktis, karena keterlaksanaan pembelajaran dan respon peserta didik memenuhi kategori praktis; dan (3) e-modul IPA termasuk efektif, karena peningkatan literasi digital dan hasil belajar peserta didik dalam kategori baik.
Determining Factors that Influence Unmet Need For Family Planning Using Geographically Weighted Logistic Regression With LASSO
Authors: Rusdy Dian Ayu Permata Sari , Thamrin Sri Astuti , Islamiyati Anna
Published: January 2025

Binary logistic regression is a regression used for categorical response variables with two possibilities: success or failure. This regression is a global model, making it inappropriate for spatial data. Binary logistic regression was then developed into geographically weighted logistic regression (GWLR). GWLR considers location factors into the model through a weight function. Nevertheless, GWLR is unable to overcome multicollinearity issue. Multicollinearity can cause the estimated parameters to be insignificant, thus it needs to be solved. A method to deal with multicollinearity is least absolute shrinkage and selection operator (LASSO). LASSO is applicable to various areas, including health, namely in the case of unmet need for family planning (FP). Unmet need for FP refers to productive-age women who do not wish to have more children or wish to postpone having children without using contraceptive methods. This study aims to obtain GWLR model with LASSO and influential factors, and acquire the performance of GWLR model with LASSO on unmet need for FP in South Sulawesi. The AIC value of the GWLR with LASSO model, which is 31,918, is less than the AIC value of the GWLR without LASSO, which is 38,879. This implies that GWLR with LASSO method is able to model unmet need for FP better than GWLR model. In addition, it was obtained that the status of unmet need for FP in 22 districts/cities was affected by the percentage of women with junior high school education or equivalent or lower, number of high-fertility women, percentage of husbands/families who refuse family planning, and number of KB staffs, while there were 2 districts/cities where the status of unmet need for KB was determined by the number of high-fertility women, percentage of husbands/families who refuse family planning, and number of FP staffs.
Comparison of Extreme Learning Machine (ELM) and Multi-Support Vector Machine (Multi-SVM) Methods in Herbal Plants Identification
Authors: Sarifah Luluk , Sa’adah Lailiyatus , Setiana Iis
Published: January 2025

In Indonesia, there are more than 2.039 species of herbal medicinal plants, which sometimes have similarities and make it difficult to identify the type of herbal plant. The purpose of this study is to facilitate the identification of herbal plant species by comparing the performance of the Extreme Learning Machine (ELM) and Multi-Support Vector Machine (Multi-SVM) methods. The ELM method was created to overcome the weaknesses of feedforward artificial neural networks, especially in terms of learning speed, while the Multi-SVM method is an advanced development of the SVM method. The stages of this research begin with image input which is through previous data acquisition, data preprocessing, and then the identification with ELM and Multi-SVM methods. Based on the simulations that have been carried out, the average accuracy on training data for the ELM method is 93%, while the Multi-SVM method is 44%. Also, the average accuracy on testing data for the ELM method is 85%, while the Multi-SVM method is 40%.
Community Detection, Topic, and Sentiment Analysis of the Palestine-Israel Issue on Social Media X
Authors: Azmina Fathnin Nur , Liebenlito Muhaza , Zulkifli Dhea Urfina
Published: January 2025

The combination of community detection, topic modeling, and sentiment analysis provides deep insights into conversation data on the social media platform X (formerly Twitter) regarding the Palestine-Israel issue. The data, collected in Indonesian using several keywords, resulted in 108,969 tweets. The analysis process began with community detection using the Leiden algorithm, which identified five communities. The three dominant communities identified are Community 1 comprising 37.13% of users, Community 2 with 26.95%, and Community 3 with 19.76%. Topic modeling using LDA revealed that these communities focused on various aspects of the conflict. Sentiment analysis using the IndoBERT model uncovered that the majority of users expressed negative attitudes such as disappointment and anger. This study provides insights into public opinions and social dynamics surrounding the conflict.
The Generalized Riemann Integral
Authors: Purba James
Published: January 2025

Riemann integration theory integrates functions on a bounded interval  as a Riemann sum approach (integral) where the fineness of the partitions is controlled by a number (norm) of the partition. In Generalized Riemann integral theory, the Riemann sum approach of functions is controlled by a gauge on tagged partition so that enabling integrating functions with much larger collections. Therefore, the theorems that apply to Generalized Riemann integral theory have differences in their hypotheses and conclusions. In this paper, theory of Generalized Riemann integral is studied by giving some examples of functions that are Generalized Riemann integrable such that they are not Riemann integrable; and proving some theorems that apply in this theory. The functions are integrable by constructing a gauge on the tagged partition of the interval such that the Riemann sum of the function is very close to some real number. Functions defined on a bounded interval that are Generalized Riemann integrable such that they are or not Riemann integrable have the general form of the function: a function f on [a,b] is continuous on [a,b]\Z and discontinuous on Z, where Z is a null set. Moreover, an unbounded function f on [a,b] is integrable, if the set Z where f is unbounded on Z is a countable set. Furthermore, these two criteria can be extended to infinite intervals, i.e. a function defined on an infinite interval can be Generalized Riemann integrable such that it is not Riemann integrable, if the set of discontinuous and unbounded points of the function is a null set. A sequence of integrable functions on an interval I that converges to a function on I, satisfies that this limit function is integrable if it satisfies that the existence of the dominating functions.