bluuebunny/crossref_metadata_2025 huggingface dataset:
Implicit, Explicit, and Structural Barriers and Facilitators for Information and Communication Technology Access in Older Adults
Authors: Gomez-Hernandez Miguel , Adrian Stine Willum , Ferre Xavier , Villalba-Mora Elena
Published: May 2022

Older adults’ usage of information and communication technology (ICT) is challenged or facilitated by perception of usefulness, technology design, gender, social class, and other unspoken and political elements. However, studies on the use of ICT by older adults have traditionally focused on explicit interactions (e.g., usability). The article then analyzes how symbolic, institutional, and material elements enable or hinder older adults from using ICT. Our ethnographic methodology includes several techniques with Spanish older adults: 15 semi-structured interviews, participant observation in nine ICT classes, online participant observation on WhatsApp and Jitsi for 3 months, and nine phone interviews due to COVID-19. The qualitative data were analyzed through Situational Analysis. We find that the elements hindering or facilitating ICT practice are implicit-symbolic (children’s surveillance, paternalism, fear, optimism, low self-esteem, and contradictory speech-act), explicit-material (affordances, physical limitations, and motivations), and structural-political (management, the pandemic, teaching, and media skepticism). Furthermore, unprivileged identities hampered the ICT practices: female gender, blue-collar jobs, illiteracy, and elementary education. However, being motivated to use ICT prevailed over having unprivileged identities. The study concludes that society and researchers should perceive older adults as operative with technologies and examine beyond explicit elements. We urge exploration of how older adults’ social identities and how situatedness affects ICT practice. Concerning explicit elements, Spanish authorities should improve and adapt ICT facilities at public senior centers and older adults’ homes, and ICT courses should foster tablet and smartphone training over computers.
Suicidality Related to the COVID-19 Lockdown in Romania: Structural Equation Modeling
Authors: Panfil Anca-Livia , Lungeanu Diana , Tamasan Simona , Bredicean Cristina , Papava Ion , Smirnova Daria , Fountoulakis Konstantinos N.
Published: May 2022

Background

Suicidality is a serious public health concern at a global scale. Suicide itself is considered to be preventable death; worldwide, suicide rates and their trends are under constant scrutiny. As part of the international COMET-G cross-sectional study, we conducted a national level investigation to examine the individual disturbances (such as anxiety, depression, or history of life-threatening attempts) and contextual factors (such as adherence to conspiracy theories or Internet use) associated with suicidality related to the COVID-19 lockdown in a lot of Romanian adults.

Participants and Methods

One thousand four hundred and forty-six adults responded to an anonymous on-line questionnaire, with mean age ± standard deviation of 47.03 ± 14.21 years (1,142 females, 292 males, 12 identified themselves as non-binary). Data were analyzed using descriptive statistics and structural equation modeling (SEM).

Results

Univariate analysis showed strong significant correlation between anxiety and depression scorings among the respondents (Spearman R = 0.776, p < 0.001). Both the suicidality scorings and the Internet use correlated fairly with anxiety and depression, with two-by-two Spearman coefficients between R = 0.334 and R = 0.370 (p < 0.001 for each). SEM analysis substantiated the emotional disturbances, previous life-threatening attempts, and younger age as significant predictors for suicidality. The patterns of reality reading (including religious inquiries, Internet use, and beliefs in conspiracy theories) did not reach the statistical significance as influential factors in the suicidality of these respondents. There was no covariance between the Internet use and belief in conspiracy theories.

Conclusion

The study confirmed the suicidality risk initially hypothesized as being associated with the history of life-threatening attempts, increased depression within the younger population, and higher anxiety during the first year of the COVID-19 pandemic and its related lockdown. National strategies for effective interventions at various levels of the healthcare system should be developed.
Psychosomatic Symptoms in Terminally Ill Cancer Patients and Its Relation With Using Complementary and Alternative Medicines: A Cross-Sectional Study in Southeast Iran
Authors: Dehghan Mahlagha , Hoseini Fatemeh Sadat , Zakeri Mohammad Ali
Published: May 2022

Background

Cancer patients face various problems and complications, which they address through various complementary and alternative medicines (CAM). The aim of this study was to investigate the relationship between CAM and psychosomatic symptoms in terminally ill cancer patients.

Methods

This cross-sectional study was performed on 221 terminally ill cancer patients (based on metastatic stage and according to the physicin diagnosis) in southeastern Iran. Convenience sampling was used to select terminally ill cancer patients. Using questionnaires like the demographic and clinical information questionnaire, Edmonton Symptom Assessment Scale (ESAS), Hospital Anxiety and Depression Scale (HADS), CAM questionnaire and satisfaction with the use of CAM, the researcher was able to compile a comprehensive picture of the population.

Results

The mean age of the participants was 51.66 ± 13.34 years. The majority of the samples were female, married, educated, and unemployed. The mean score for the physical symptoms of the participants according to ESAS was 22.25 ± 17.57 which was less than the midpoint of the scale (the possible score of ESAS was 0–100). Only 2.7% (n = 6) and 0.9% (n = 2) of the participants had mild and moderate anxiety, respectively, and the other participants' anxiety levels were normal. Only 7.7% (n = 17) and 4.1% (n = 9) of the participants had mild and moderate depression, respectively, and the other participants' depression levels were normal. Last year, 87.3% of the participants used at least one type of CAM. Aside from prayer, 42.1% of the participants used at least one type of CAM in the last year. Prayer was used by 83.7% of the participants, medicinal plants by 35.8%, massage by 9.5%, dietary supplements by 3.6%, wet cupping by 3.2%, relaxation and meditation by 2.7%, dry cupping by 2.4%, and acupuncture by 0.5%. The common reason for using CAM was to reduce the stress and anxiety caused by cancer and to treat it. There were no significant differences in physical and psychological symptoms between the CAM-users and non-CAM users.

Conclusion

Patients with cancer have a relatively low level of psychosomatic symptoms, and the primary reason for using CAM was to relieve stress and anxiety associated with cancer and treat it. However, psychosomatic symptoms were the same for CAM and non-CAM users. Because so many people with cancer use CAM, future studies should look into why and how CAM is used.
Targeting the Salience Network: A Mini-Review on a Novel Neuromodulation Approach for Treating Alcohol Use Disorder
Authors: Padula Claudia B. , Tenekedjieva Lea-Tereza , McCalley Daniel M. , Al-Dasouqi Hanaa , Hanlon Colleen A. , Williams Leanne M. , Kozel F. Andrew , Knutson Brian , Durazzo Timothy C. , Yesavage Jerome A. , Madore Michelle R.
Published: May 2022

Alcohol use disorder (AUD) continues to be challenging to treat despite the best available interventions, with two-thirds of individuals going on to relapse by 1 year after treatment. Recent advances in the brain-based conceptual framework of addiction have allowed the field to pivot into a neuromodulation approach to intervention for these devastative disorders. Small trials of repetitive transcranial magnetic stimulation (rTMS) have used protocols developed for other psychiatric conditions and applied them to those with addiction with modest efficacy. Recent evidence suggests that a TMS approach focused on modulating the salience network (SN), a circuit at the crossroads of large-scale networks associated with AUD, may be a fruitful therapeutic strategy. The anterior insula or dorsal anterior cingulate cortex may be particularly effective stimulation sites given emerging evidence of their roles in processes associated with relapse.
Molecular Epidemiology of Human Papillomavirus Infection Among Chinese Women With Cervical Cytological Abnormalities
Authors: Wong Eliza Lai-Yi , Cheung Annie Wai-Ling , Chen Zigui , Wong Amy Yuen-Kwan , Yeung Apple Chung-Man , Yau Peter Sen-Yung , Chan Paul Kay-Sheung
Published: May 2022

Background

Virtually all invasive cervical cancers are caused by persistent genital human papillomavirus (HPV) infection. Therefore, HPV-based screening becomes an essential tool as one of the cervical prevention strategies to reduce the disease burden. Population-specific epidemiologic information on HPV infection among women with cytological abnormalities is essential to inform the strategy of HPV-based screening programme. The study also explored the presence of cutaneous HPV types (Beta-β and Gamma-γ) in cervical infections.

Methods

A cross-sectional study on Chinese women aged ≥25 years who were referred to public specialist out-patient clinics for colposcopy or further management of cervical cytological abnormalities were recruited between 2015 and 2016 in Hong Kong. HPV was detected and typified by the novel PCR-based Next-Generation Sequencing (NGS) strategies.

Results

The overall HPV infection rate was 74% and detected in 222 of the 300 respondents, with the prevalence of cutaneous HPV infection being 2.3%. The overall prevalence of HPV infection among women with current cytological abnormalities was 79.1% (197/249). The age-specific prevalence of HPV (any-type HPV infection) among women with cytological abnormalities reached the first peak with 87.9% in the age group of 35–39 years and gradually declined to 56.0% at 55–59 years. While a second peak occurred at 65 years or above (92.9%). HPV58 (13.7%), HPV52 (11.7%), HPV53 (11.2%), HPV16 (10.0%), HPV18 (5.2%), and HPV51 (5.2%) were the top five high-risk HPV genotypes among women with cytological abnormalities. Any-HPV type infection was significantly associated with an abnormal cervical smear (OR = 3.7; 95% CI 2.0–7.1), and high-risk HPV infection was also significantly associated with an abnormal cervical smear (OR = 6.3; 95% CI 3.0–13.5).

Conclusion

New evidence on the second peak of HPV infection at ≥65 years old suggests the necessity to review the current guideline for the cervical screening program extending to age 65 and above. Moreover, the high prevalence of two HPV genotypes—high-risk HPV51 and potential high-risk HPV53, among women with cytological abnormalities—suggests further research work is needed to confirm the contributory role of HPV51 and HPV53 in cervical cancer and the need for inclusion in the next generation of the HPV vaccine.
Cost-Effectiveness of Posaconazole vs. First-Generation Triazoles for the Prevention of Invasive Fungal Infections Among High-Risk Patients With Hematological Malignancies in China
Authors: Shi Changcheng , Ye Jian , Xie Yaping , Dong Rong , Jin Weizhong , Wang Linling , Fang Yingying , Shan Qiyuan , Lin Nengming
Published: May 2022

Background

Posaconazole is confirmed to be more effective for preventing invasive fungal infections (IFIs) than first-generation triazoles (fluconazole and itraconazole), but its economic value has not been comprehensively evaluated in China. This study compared the cost-effectiveness of these two antifungal prophylaxis regimens in hematological-malignancy patients at high risk for IFIs from the Chinese healthcare perspective.

Methods

A hybrid decision tree and Markov model were built using published data to estimate the total costs and quality-adjusted life-years (QALYs) of antifungal prophylaxis with posaconazole oral suspension and first-generation triazoles. Regimens with an incremental cost-effectiveness ratio (ICER) lower than the threshold of willingness to pay (WTP) were considered cost-effective. One-way and probabilistic sensitivity analyses were performed to assess model robustness. The regional imbalance of economic development and the tablet formulation of posaconazole were considered in the scenario analyses.

Results

In the base-case analysis, posaconazole oral suspension provided an additional 0.109 QALYs at an incremental cost of $954.7, yielding an ICER of $8,784.4/QALY, below the national WTP threshold of $31,315/QALY. One-way and probabilistic sensitivity analyses showed that the results were robust. Scenario analyses showed that the base-case ICER was consistently below the WTP thresholds of all 31 Chinese provinces, with the likelihood of posaconazole being cost-effectiveness ranging from 78.1 to 99.0%. When the posaconazole oral suspension was replaced by the tablet formulation, the ICER increased to $29,214.1/QALY, still below the national WTP threshold and WTP thresholds of 12 provinces.

Conclusions

Posaconazole oral suspension is a highly cost-effective regimen for preventing IFI in high-risk hematological-malignancy patients from the Chinese healthcare perspective. Posaconazole tablets may also be considered in some high-income regions of China.
Post-implementation Review of the Himalaya Home Care Project for Home Isolated COVID-19 Patients in Nepal
Authors: Amatya Rakchya , Mishra Kritika , Karki Kshitij , Puri Isha , Gautam Archita , Thapa Sweta , Katwal Urmila , Veer Siddhesh , Zervos John , Kaljee Linda , Prentiss Tyler , Zenlea Kate , Maki Gina , Rayamajhi Pawan Jung , Khanal Narendra K. , Thapa Pomawati , Upadhyaya Madan Kumar , Bajracharya Deepak
Published: May 2022

Background:

The emergence of coronavirus disease 2019 (COVID-19) has resulted in a pandemic that has significantly impacted healthcare systems at a global level. Health care facilities in Nepal, as in other low- and middle-income countries, have limited resources for the treatment and management of COVID-19 patients. Only critical cases are admitted to the hospital resulting in most patients in home isolation.

Methods

Himalaya Home Care (HHC) was initiated to monitor and provide counseling to home isolated COVID-19 patients for disease prevention, control, and treatment. Counselors included one physician and four nurses. Lists of patients were obtained from district and municipal health facilities. HHC counselors called patients to provide basic counseling services. A follow-up check-in phone call was conducted 10 days later. During this second call, patients were asked about their perceptions of the HHC program. Project objects were: (1) To support treatment of home isolated persons with mild to moderate COVID-19, decrease burden of hospitalizations, and decrease risks for disease transmission; and, (2) To improve the health status of marginalized, remote, and vulnerable populations in Nepal during the COVID-19 pandemic.

Results

Data from 5823 and 3988 patients from May 2021-February 2022 were entered in initial and follow-up forms on a REDCap database. The majority of patients who received counseling were satisfied. At follow-up, 98.4% of respondents reported that HHC prevented hospitalization, 76.5% reported they could manage their symptoms at home, and 69.5% reported that counseling helped to limit the spread of COVID-19 in their household.

Conclusions

Telehealth can be an essential strategy for providing services while keeping patients and health providers safe during the COVID-19 pandemic.
Temporal and Spatial Patterns of Groundwater Recharge Across a Small Watershed in the California Sierra Nevada Mountains
Authors: Meadows Christina , Hagedorn Benjamin
Published: May 2022

Mountain-block groundwater recharge is a crucial freshwater source in arid to semiarid watersheds worldwide; yet its quantification is difficult due to (1) hydrogeological heterogeneities especially in bedrock-dominated regimes, (2) drastic altitudinal ranges in climate, land use and land cover, and (3) mixing with deep groundwater derived from adjacent basins (i.e., interbasin groundwater flow). In this study, we test the utility of soil water-balance (SWB) modeling to quantify mountain-block groundwater recharge in the South Fork Tule River watershed in the California Sierra Nevada Mountains. This 1,018 km2 watershed is instrumented with 3 USGS stream gages that allow for the development of a refined recharge (i.e., baseflow) calibration dataset via multi-objective optimization-based hydrograph separation. The SWB model was used to compute groundwater recharge and other water balance components at a daily time step using a 30-m grid cell size for a 40-year (1980–2019) study period. Mean annual recharge and runoff were estimated at 3.7 in/yr (3.0 m3/s) and 1.4 in/yr (1.2 m3/s), respectively, with modified Nash Sutcliffe Efficiency indices of 0.61 between baseflow and SWB-derived recharge, and 0.90 between hydrograph separation- and SWB-derived runoff. There is a strong correlation between annual recharge and rainfall (Pearson R = 0.95, p < 0.001) which attests to short residence times in the unsaturated zone and the immediate impact of droughts in 1990, 1999, and 2013. However, results of a modified Mann-Kendall trend analysis indicate no directional trends in recharge or runoff throughout the study period. Parameter sensitivity analyses reveal a persistent overprediction of recharge over baseflow that is particularly pronounced in the upper reaches of the watershed. This is likely related to the SWB model only considering soil characteristics at the surface and not simulating the fate of potential recharge below the root zone where it may be impeded from reaching the aquifer by shallow, impermeable bedrock. This limitation should be considered carefully for future water supply projections in this and comparable bedrock-dominated settings.
A Perspective on Solar Energetic Particles
Authors: Reames Donald V.
Published: May 2022

The author has been fortunate to observe and participate in the rise of the field of solar energetic particles (SEPs), from the early abundance studies, to the contemporary paradigm of shock acceleration in large SEP events, and element abundance enhancements that are power laws in mass-to-charge ratios from H to Pb. Through painful evolution the “birdcage” model and the “solar-flare myth” came and went, leaving us with shock waves and solar jets that can interact as sources of SEPs.
Visual Strategies for Eye and Head Movements During Table Tennis Rallies
Authors: Shinkai Ryosuke , Ando Shintaro , Nonaka Yuki , Kizuka Tomohiro , Ono Seiji
Published: May 2022

The purpose of this study was to clarify the properties of visual strategies for gaze, eye, and head movements in skilled table tennis players during rallies. Collegiate expert and semi-expert table tennis players conducted forehand rallies at a constant tempo using a metronome. Two tempo conditions were used in the order of 130 and 150 bpm. Participants conducted a 20-stroke rally under each tempo condition. Horizontal and vertical angles between the gaze point and ball positions at the time the ball bounced (gaze-ball angle) were analyzed with the image that was recorded by an eye tracking device equipped with Gyro sensor. Eye and head movements during rallies were also recorded with the eye tracking device and Gyro sensor, respectively. The results showed that the gaze-ball angle of expert players was significantly larger than that of semi-expert players. This result indicates that expert players tended to keep their gaze position on the ball shorter than semi-expert players. We also found that eye movements of expert players were significantly smaller than that of semi-expert players. Furthermore, as the result of multiple regression analysis, the effect of eye movements on the gaze-ball angle was significantly higher than that of head movements. This result indicates that the gaze-ball angle during table tennis rallies could be associated with eye movements rather than head movements. Our findings suggest that the visual strategies used during table tennis rallies are different between expert and semi-expert players, even though they both have more than 10 years of experience.
Efficacy and Safety of Totally Laparoscopic Gastrectomy Compared with Laparoscopic-Assisted Gastrectomy in Gastric Cancer: A Propensity Score-Weighting Analysis
Authors: Zhong Xin , Wei Meng , Ouyang Jun , Cao Weibo , Cheng Zewei , Huang Yadi , Liang Yize , Zhao Rudong , Yu Wenbin
Published: May 2022

Objectives

To compare the short- and long-term outcomes of totally laparoscopic gastrectomy (TLG) with laparoscopic-assisted gastrectomy (LAG) in gastric cancer (GC) patients and evaluate the efficacy and safety of TLG.

Methods

This retrospective study was based on GC patients who underwent laparoscopic radical gastrectomy in the Qilu Hospital from January 2017 to December 2020. The groups’ variables were balanced by using the propensity score-based inverse probability of treatment weighting (PS-IPTW). The primary outcomes were 3-year relapse-free survival (RFS) and 3-year overall survival (OS). Postoperative recovery and complications were the secondary outcomes.

Results

A total of 250 GC patients were included in the study. There were no significant differences in baseline and pathological features between the TLG and the LAG groups after the PS-IPTW. TLG took around 30 min longer than LAG, while there were more lymph nodes obtained and less blood loss throughout the procedure. TLG patients had less wound discomfort than LAG patients in terms of short-term prognosis. There were no significant differences between groups in the 3-year RFS rate [LAG vs. TLG: 78.86% vs. 78.00%; hazard ratio (HR) = 1.14, 95% confidence interval (CI), 0.55–2.35; p = 0.721] and the 3-year OS rate (LAG vs. TLG: 78.17% vs. 81.48%; HR = 0.98, 95% CI, 0.42–2.27; p = 0.955). The lymph node staging was found to be an independent risk factor for tumor recurrence and mortality in GC patients with laparoscopic surgery. The subgroup analysis revealed similar results of longer operation time, less blood loss, and wound discomfort in totally laparoscopic distal gastrectomy, while the totally laparoscopic total gastrectomy showed benefit only in terms of blood loss.

Conclusion

TLG is effective and safe in terms of short- and long-term outcomes, with well-obtained lymph nodes, decreased intraoperative blood loss, and postoperative wound discomfort, which may be utilized as an alternative to LAG.
Clinical Course and Diagnostic Findings of Biopsy Controlled Presumed Immune-Mediated Polyneuropathy in 70 European Cats
Authors: van Renen Jana , Fischer Andrea , Kolb Ninja , Wielaender Franziska , Zablotski Yury , Nessler Jasmin , Tipold Andrea , Cappello Rodolfo , Flegel Thomas , Loderstedt Shenja , Gnirs Kirsten , Rentmeister Kai , Rupp Stephan , von Klopmann Thilo , Steffen Frank , Jurina Konrad , Del Vecchio Omar V. , Deutschland Martin , König Florian , Gandini Gualtiero , Harcourt-Brown Tom , Kornberg Marion , Bianchi Ezio , Gagliardo Teresa , Menchetti Marika , Schenk Henning , Tabanez Joana , Matiasek Kaspar , Rosati Marco
Published: May 2022

There is a paucity of information on the clinical course and outcome of young cats with polyneuropathy. The aim of the study was to describe the clinical features, diagnostic investigations, and outcome of a large cohort of cats with inflammatory polyneuropathy from several European countries. Seventy cats with inflammatory infiltrates in intramuscular nerves and/or peripheral nerve biopsies were retrospectively included. Information from medical records and follow up were acquired via questionnaires filled by veterinary neurologists who had submitted muscle and nerve biopsies (2011–2019). Median age at onset was 10 months (range: 4–120 months). The most common breed was British short hair (25.7%), followed by Domestic short hair (24.3%), Bengal cat (11.4%), Maine Coon (8.6%) and Persian cat (5.7%), and 14 other breeds. Male cats were predominantly affected (64.3%). Clinical signs were weakness (98.6%) and tetraparesis (75.7%) in association with decreased withdrawal reflexes (83.6%) and, less commonly, cranial nerve signs (17.1%), spinal pain/hyperesthesia (12.9%), and micturition/defecation problems (14.3%). Onset was sudden (30.1%) or insidious (69.1%), and an initial progressive phase was reported in 74.3%. Characteristic findings on electrodiagnostic examination were presence of generalized spontaneous electric muscle activity (89.6%), decreased motor nerve conduction velocity (52.3%), abnormal F-wave studies (72.4%), pattern of temporal dispersion (26.1%) and unremarkable sensory tests. The clinical course was mainly described as remittent (49.2%) or remittent-relapsing (34.9%), while stagnation, progressive course or waxing and waning were less frequently reported. Relapses were common and occurred in 35.7% of the cats' population. An overall favorable outcome was reported in 79.4% of patients. In conclusion, young age at the time of diagnosis and sudden onset of clinical signs were significantly associated with recovery (p < 0.05). Clinical and electrodiagnostic features and the remittent-relapsing clinical course resembles juvenile chronic inflammatory demyelinating polyneuropathy (CIDP), as seen in human (children/adolescents), in many aspects.
A First Attempt to Combine NIRS and Plenoptic Cameras for the Assessment of Grasslands Functional Diversity and Species Composition
Authors: Taugourdeau Simon , Dionisi Mathilde , Lascoste Mylène , Lesnoff Matthieu , Capron Jean Marie , Borne Fréderic , Borianne Philippe , Julien Lionel
Published: May 2022

Grassland represents more than half of the agricultural land. Numerous metrics (biomass, functional trait, species composition) can be used to describe grassland vegetation and its multiple functions. The measures of these metrics are generally destructive and laborious. Indirect measurements using optical tools are a possible alternative. Some tools have high spatial resolutions (digital camera), and others have high spectral resolutions (Near Infrared Spectrometry NIRS). A plenoptic camera is a multifocal camera that produces clear images at different depths in an image. The objective of this study was to test the interest of combining plenoptic images and NIRS data to characterize different descriptors of two Mediterranean legumes mixtures. On these mixtures, we measured biomass, species biomass, and functional trait diversity. NIRS and plenoptic images were acquired just before the field measurements. The plenoptic images were analyzed using Trainable Weka Segmentation ImageJ to evaluate the percentage of each species in the image. We calculated the average and standard deviation of the different colors (red, green, blue reflectance) in the image. We assessed the percentage of explanation of outputs of the images and NIRS analyses using variance partition and partial least squares. The biomass Trifolium michelianum and Vicia sativa were predicted with more than 50% variability explained. For the other descriptors, the variability explained was lower but nevertheless significant. The percentage variance explained was nevertheless quite low, and further work is required to produce a useable tool, but this work already demonstrates the interest in combining image analysis and NIRS.
Design of Stretchable Style Pick-Up Device for Tomato Seedling Transplanters
Authors: Ren Ling , Zhao Bindong , Cao Weibin , Song Wenbin , Zhao Ming
Published: May 2022

To solve tomato planting problems, such as high labor intensity and low efficiency, we designed a stretchable style pick-up device, which met the requirements of whole-row picking and improved the efficiency and speed of seedling picking. We designed the parts of the device according to the height of the seedlings and the size of the tray. Seedling analysis was carried out and a parametric model created. Additionally, an evaluation of seedling picking was developed, which included both parallel and vertical displacement. We manufactured the parts according to the simulation parameters, which were optimized by ADAMS. The parts were assembled and the trajectory test carried out. When whole-row seedlings were grown for 30 days, the moisture content was 65.21%, the picking success rate was 92.19%, leaf damage rate was 3.13%, and the substrate damage rate was 1.54%. The study can provide a reference for the design of automatic tomato transplanters.
Why-Oh-Why? Dark Brooders Reduce Injurious Pecking, Though Are Still Not Widely Used in Commercial Rearing of Layer Pullets
Authors: Sirovnik Janja , Riber Anja B.
Published: May 2022

Dark brooders, i.e., horizontal heating elements for chicks equipped with curtains, mimic some aspects of maternal care, such as the provision of heat and a dark area for chicks to rest. Thus, they can be considered as artificial passive replacements of a mother hen. Despite their advantages in animal welfare and the likely positive outcomes in production and economy, dark brooders are rarely used in commercial layer pullet facilities. The main positive effect on welfare is a reduction of injurious pecking during the rearing and laying periods, which results in improved feather cover and reduced skin injuries and mortality due to cannibalism. Other welfare benefits include improved rest in dark-brooded chicks and reduced fearfulness at all ages tested (i.e., from 4 to 26 weeks). The impact on production and economy is seen in a reduction of the energy costs in the first weeks of life due to radiant heating, as well as improved total egg production and reduced floor egg laying. The aim of this paper is to review the existing literature on the effects of dark brooders on injurious pecking and other welfare issues in layers, including speculations on the possible explanations for improved welfare. We also discuss the possible reasons for why dark brooders are not applied more commonly in commercial practice, including insufficient information on the economic aspects of using brooders and the lack of commercially available brooder options.
Study on the Catalytic Decomposition Reaction of N2O on MgO (100) in SO2 and CO Environments
Authors: Hu Xiaoying , Zhang Erbo , Li Wenjun , Wu Lingnan , Zhou Yiyou , Zhang Hao , Dong Changqing
Published: May 2022

To study the role of MgO in the reduction of N2O in circulating fluidized bed boilers, density functional theory was used to evaluate heterogeneous decomposition. The interference of SO2 and CO on N2O was considered. N2O on MgO (100) is a two-step process that includes O transfer and surface recovery processes. The O transfer process is the rate-determining step with barrier energy of 1.601 eV, while for the Langmuir–Hinshelwood and Eley–Rideal surface recovery mechanisms, the barrier energies are 0.840 eV and 1.502 eV, respectively. SO2 has a stronger interaction with the surface-active O site than that of N2O. SO2 will occupy the active site and hinder N2O decomposition. CO cannot improve the catalysis of MgO (100) for N2O because O transfer is the rate-determining step. Compared with homogeneous reduction by CO, MgO has a limited catalytic effect on N2O, where the barrier energy decreases from 1.691 eV to 1.601 eV.
Study on the Autonomous Walking of an Underground Definite Route LHD Machine Based on Reinforcement Learning
Authors: Zhao Shuo , Wang Liguan , Zhao Ziyu , Bi Lin
Published: May 2022

The autonomous walking of an underground load-haul-dump (LHD) machine is a current research hotspot. The route of an underground LHD machine is generally definite, and most research is based on the logic of positioning-decision control. Based on a reinforcement learning algorithm, a new autonomous walking training algorithm, Traditional Control Based DQN (TCB-DQN), combining the methods of traditional reflective navigation and reinforcement learning deep q-networks (DQN), is proposed. Compared with the logic of location-decision control, TCB-DQN does not require accurate positioning, but only determines how to reach the endpoint by sensing the distance from the endpoint. Through experimental verification, after using the TCB-DQN algorithm for training in a simple tunnel, the LHD machine could achieve a walking effect similar to that of a human driver’s manual operation, while after training in a more complex tunnel, the TCB-DQN algorithm could reach the endpoint smoothly.
Relation between Step-To-Step Transition Strategies and Walking Pattern in Older Adults
Authors: Dewolf Arthur H. , Meurisse Guillaume M. , Ivanenko Yury , Lacquaniti Francesco , Bastien Guillaume J. , Schepens Bénédicte
Published: May 2022

In older adults, two different modes of step-to-step transition have been observed: an anticipated mode when the redirection of the centre of mass of the body (COM) begins before double stance and another when the transition begins during double stance. However, the impact of transition mode on gait kinetics and kinematics has not been investigated. Age and step-to-step-transition-related differences in intersegmental coordination and in the COM trajectory during walking were identified. Fifteen young (24.1 ± 0.7 y.o.) and thirty-six older adults (74.5 ± 5.0 y.o.) walked on a treadmill at 1.11 m s−1 and 1.67 m s−1. Lower-limb motion and ground reaction force were recorded. The COM dynamics were evaluated by measuring the pendulum-like exchange of the COM energies. While all young adults and 21 of the older adults used an anticipated transition, 15 older adults presented a non-anticipated transition. Previously documented changes of intersegmental coordination with age were accentuated in older adults with non-anticipated transition (p < 0.001). Moreover, older adults with non-anticipated transition had a smaller pendulum-like energy exchange than older adults with anticipated transition (p = 0.03). The timing of COM redirection is linked to kinematic and mechanic modification of gait and could potentially be used as a quantitative assessment of age-related decline in gait.
Book Review: Pfister, C.; Wanner, H. Climate and Society in Europe: The Last Thousand Years; Haupt: Berne, Switzerland, 2021; ISBN: 978-3-258-08234-9
Authors: Contino Antonio
Published: May 2022

The book Climate and Society in Europe: The Last Thousand Years, through an appropriate interdisciplinary approach, identifies and analyses the nexus between past and present climatic variability (opening also a window on the future) but also its impact on environmental contexts, on historical events and on the becoming of European societies in the last millennium. This relevant publication is a must not only for scholars but also for any reader who is interested in the study of climate and its history and is curious to find out how much climate change has had an impact on the history of human societies in Europe. Climate and Society in Europe: The Last Thousand Years, written by two of the leading climate scientists in Europe, achieves an advanced goal through an innovative methodological approach, harmoniously managing to connect the historical climate sciences with the natural climate sciences, thus obtaining new and significant insights into both branches of knowledge. The authors paint an exhaustive picture of the relationships between climatic variability (long and short term) and historical and social aspects in Europe, producing a clear and intriguing text even for non-insiders, with an excellent iconographic apparatus and numerous in-depth inserts.
Effect of Prenatal Opioid Exposure on the Human Placental Methylome
Authors: Borrelli Kristyn N. , Wachman Elisha M. , Beierle Jacob A. , Taglauer Elizabeth S. , Jain Mayuri , Bryant Camron D. , Zhang Huiping
Published: May 2022

Prenatal exposure to addictive drugs can lead to placental epigenetic modifications, but a methylome-wide evaluation of placental DNA methylation changes after prenatal opioid exposure has not yet been performed. Placental tissue samples were collected at delivery from 19 opioid-exposed and 20 unexposed control full-term pregnancies. Placental DNA methylomes were profiled using the Illumina Infinium HumanMethylationEPIC BeadChip. Differentially methylated CpG sites associated with opioid exposure were identified with a linear model using the ‘limma’ R package. To identify differentially methylated regions (DMRs) spanning multiple CpG sites, the ‘DMRcate’ R package was used. The functions of genes mapped by differentially methylated CpG sites and DMRs were further annotated using Enrichr. Differentially methylated CpGs (n = 684, unadjusted p < 0.005 and |∆β| ≥ 0.05) were mapped to 258 genes (including PLD1, MGAM, and ALCS2). Differentially methylated regions (n = 199) were located in 174 genes (including KCNMA1). Enrichment analysis of the top differentially methylated CpG sites and regions indicated disrupted epigenetic regulation of genes involved in synaptic structure, chemical synaptic transmission, and nervous system development. Our findings imply that placental epigenetic changes due to prenatal opioid exposure could result in placental dysfunction, leading to abnormal fetal brain development and the symptoms of opioid withdrawal in neonates.
Targeted Molecular Imaging Probes Based on Magnetic Resonance Imaging for Hepatocellular Carcinoma Diagnosis and Treatment
Authors: Zhao Dongxu , Cao Jian , Zhang Lei , Zhang Shaohua , Wu Song
Published: May 2022

Hepatocellular carcinoma (HCC) is the sixth most commonly malignant tumor and the third leading cause of cancer-related death in the world, and the early diagnosis and treatment of patients with HCC is core in improving its prognosis. The early diagnosis of HCC depends largely on magnetic resonance imaging (MRI). MRI has good soft-tissue resolution, which is the international standard method for the diagnosis of HCC. However, MRI is still insufficient in the diagnosis of some early small HCCs and malignant nodules, resulting in false negative results. With the deepening of research on HCC, researchers have found many specific molecular biomarkers on the surface of HCC cells, which may assist in diagnosis and treatment. On the other hand, molecular imaging has progressed rapidly in recent years, especially in the field of cancer theranostics. Hence, the preparation of molecular imaging probes that can specifically target the biomarkers of HCC, combined with MRI testing in vivo, may achieve the theranostic purpose of HCC in the early stage. Therefore, in this review, taking MR imaging as the basic point, we summarized the recent progress regarding the molecular imaging targeting various types of biomarkers on the surface of HCC cells to improve the theranostic rate of HCC. Lastly, we discussed the existing obstacles and future prospects of developing molecular imaging probes as HCC theranostic nanoplatforms.
Double Competitive Immunodetection of Small Analyte: Realization for Highly Sensitive Lateral Flow Immunoassay of Chloramphenicol
Authors: Sotnikov Dmitriy V. , Barshevskaya Lyubov V. , Bartosh Anastasia V. , Zherdev Anatoly V. , Dzantiev Boris B.
Published: May 2022

A new scheme of reagents interaction for lateral flow immunoassay (LFIA) is proposed, which combines the features of competitive and sandwich assay and provides highly sensitive detection of low-molecular-weight analytes. Namely, the antigen in the sample interferes with the formation of the antibody (on the membrane)–hapten-protein–antibody (on the nanoparticle-marker) complex, competing with hapten-protein conjugate in both reactions. The proposed scheme was modelled using COPASI software, with a prediction of limit of detection (LOD) decrease by one order of magnitude compared to the standard competitive LFIA. This feature was experimentally confirmed for the detection of chloramphenicol (CAP) in honey. When tested in spiked honey, the visual LOD was 50 ng/mL for the common scheme and 5 ng/mL for the proposed scheme. Instrumental LOD was 300 pg/mL (1.2 µg/kg in conversion per sample weight of honey) in the standard scheme and 20 pg/mL (80 ng/kg in conversion per sample weight of honey) in the proposed scheme.
Xylanase Production by Talaromyces amestolkiae Valuing Agroindustrial Byproducts
Authors: Barbieri Giórgia S. , Bento Heitor B. S. , de Oliveira Fernanda , Picheli Flávio P. , Dias Lídia M. , Masarin Fernando , Santos-Ebinuma Valéria C.
Published: May 2022

In general, agroindustrial byproducts can be easily assimilated by several microorganisms due to their composition, which is rich in carbohydrates. Therefore, they could be appropriate for use as raw materials in a sustainable refinery concept, including the production of hydrolytic enzymes with industrial applicability. In this work, xylanase production by the filamentous fungi Talaromyces amestolkiae in submerged culture was evaluated using five agroindustrial byproducts, namely, wheat bran, citrus pulp, rice bran, peanut skin, and peanut shell. Firstly, the aforementioned byproducts were characterized in terms of cellulose, xylan, lignin, and extractives. Next, production studies were performed, and wheat bran generated the highest enzymatic activity (5.4 U·mL−1), probably because of its large amount of xylan. Subsequently, a factorial design was performed to evaluate the independent variables yeast extract, wheat bran, K2HPO4, and pH, aiming to improve the variable response, xylanase activity. The condition that promoted the highest production, 13.02 U·mL−1 (141% higher than the initial condition), was 20 g·L−1 wheat bran, 2.5 g·L−1 yeast extract, 3 g·L−1 K2HPO4, and pH 7. Thus, industrial byproducts with a high content of xylan can be used as a culture medium to produce xylanase enzymes with a Talaromyces strain through an economical and sustainable approach.
Defect Identification of Concrete Piles Based on Numerical Simulation and Convolutional Neural Network
Authors: Wu Chuan-Sheng , Zhang Jian-Qiang , Qi Ling-Ling , Zhuo De-Bing
Published: May 2022

Defects in pile foundations, such as neck defects, bulge imperfections, weak concretes, cracks, and broken piles, can cause a decrease in the bearing capacity and the structural stability of the foundation. Identification of the type of defect is vital in formulating a reasonable repair plan for the pile foundation. In this study, the authors proposed a scheme to identify the types of defects in concrete piles based on a convolution neural network and a low-strain pile integrity test (LSPIT). A batch modeling method of defective pile foundations using Python script was also proffered. The different degrees of signals of five types of defective pile foundations were simulated by this method. The original data were decomposed and reconstructed by wavelet packet decomposition (WPT). To prevent the data from losing too much information after WPT, the data of 400 × 1 after decomposition and reconstruction were processed by dimension-raising to obtain the data of 20 × 20 × 1. Then, the multidimensional feature index of 20 × 20 × 2 was generated by index fusion with the original data. Finally, the data were input onto convolutional neural network (CNN) as a training parameter. Following an improvement of the dataset, the recognition accuracy of the type of defect in the pile foundation by the proposed identification scheme reached 94.4%.
Looking at Thyroid Cancer from the Tumor-Suppressor Genes Point of View
Authors: Rajabi Sadegh , Alix-Panabières Catherine , Alaei Arshia Sharbatdar , Abooshahab Raziyeh , Shakib Heewa , Ashrafi Mohammad Reza
Published: May 2022

Thyroid cancer is the most frequent endocrine malignancy and accounts for approximately 1% of all diagnosed cancers. A variety of mechanisms are involved in the transformation of a normal tissue into a malignant one. Loss of tumor-suppressor gene (TSG) function is one of these mechanisms. The normal functions of TSGs include cell proliferation and differentiation control, genomic integrity maintenance, DNA damage repair, and signaling pathway regulation. TSGs are generally classified into three subclasses: (i) gatekeepers that encode proteins involved in cell cycle and apoptosis control; (ii) caretakers that produce proteins implicated in the genomic stability maintenance; and (iii) landscapers that, when mutated, create a suitable environment for malignant cell growth. Several possible mechanisms have been implicated in TSG inactivation. Reviewing the various TSG alteration types detected in thyroid cancers may help researchers to better understand the TSG defects implicated in the development/progression of this cancer type and to find potential targets for prognostic, predictive, diagnostic, and therapeutic purposes. Hence, the main purposes of this review article are to describe the various TSG inactivation mechanisms and alterations in human thyroid cancer, and the current therapeutic options for targeting TSGs in thyroid cancer.
The Utilization of Diffusion Tensor Imaging as an Image-Guided Tool in Brain Tumor Resection Surgery: A Systematic Review
Authors: Manan Aiman Abdul , Yahya Noorazrul , Idris Zamzuri , Manan Hanani Abdul
Published: May 2022

The diffusion tensor imaging technique has been recognized as a neuroimaging tool for in vivo visualization of white matter tracts. However, DTI is not a routine procedure for preoperative planning for brain tumor resection. Our study aimed to systematically evaluate the effectiveness of DTI and the outcomes of surgery. The electronic databases, PubMed/MEDLINE and Scopus, were searched for relevant studies. Studies were systematically reviewed based on the application of DTI in pre-surgical planning, modification of operative planning, re-evaluation of preoperative DTI data intraoperatively, and the outcome of surgery decisions. Seventeen studies were selected based on the inclusion and exclusion criteria. Most studies agreed that preoperative planning using DTI improves postoperative neuro-deficits, giving a greater resection yield and shortening the surgery time. The results also indicate that the re-evaluation of preoperative DTI intraoperatively assists in a better visualization of white matter tract shifts. Seven studies also suggested that DTI modified the surgical decision of the initial surgical approach and the rate of the GTR in tumor resection surgery. The utilization of DTI may give essential information on white matter tract pathways, for a better surgical approach, and eventually reduce the risk of neurologic deficits after surgery.
Oncological Treatment-Related Fatigue in Oncogeriatrics: A Scoping Review
Authors: André Louise , Antherieu Gabriel , Boinet Amélie , Bret Judith , Gilbert Thomas , Boulahssass Rabia , Falandry Claire
Published: May 2022

Fatigue is a highly prevalent symptom in both cancer patients and the older population, and it contributes to quality-of-life impairment. Cancer treatment-related fatigue should thus be included in the risk/benefit assessment when introducing any treatment, but tools are lacking to a priori estimate such risk. This scoping review was designed to report the current evidence regarding the frequency of fatigue for the different treatment regimens proposed for the main cancer indications, with a specific focus on age-specific data, for the following tumors: breast, ovary, prostate, urothelium, colon, lung and lymphoma. Fatigue was most frequently reported using the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) versions 3 to 5. A total of 324 regimens were analyzed; data on fatigue were available for 217 (67%) of them, and data specific to older patients were available for 35 (11%) of them; recent pivotal trials have generally reported more fatigue grades than older studies, illustrating increasing concern over time. This scoping review presents an easy-to-understand summary that is expected to provide helpful information for shared decisions with patients regarding the anticipation and prevention of fatigue during each cancer treatment.