bluuebunny/crossref_metadata_2025 huggingface dataset:
MARKETING DIGITAL E CANAIS DE VENDA: ANÁLISE EM UMA MICROEMPRESA VAREJISTA
Authors: De Souza Freitas Aline , Santos Luana Ferreira dos , Caetano de Aguiar Cristina
Published: May 2022

O artigo tem como objetivo analisar a viabilidade de implementação de ferramentas de vendas on-line dos produtos em uma microempresa que atua no ramo do comércio varejista de roupas e acessórios. O estudo foi desenvolvido com base no referencial teórico a respeito do composto de marketing (Produto, Preço, Praça e Promoção), com foco no “P de Praça” e no e-commerce. De natureza quantitativa e qualitativa, foi empregada a metodologia de pesquisa de campo, tendo como instrumento para coleta de dados a aplicação de questionários para 178 clientes, utilizando a ferramenta Google Forms. Os resultados apontaram que 99% dos entrevistados têm acesso à internet diariamente principalmente por meio do celular. Grande parte deles tem o costume de fazer compras pela internet por meio de sites ou pelo Instagram e apresentam média confiança em lojas on-line. Os respondentes julgam importante realizar compras on-line no período de pandemia do Coronavírus, por isso apontam que comprariam de forma on-line nesse contexto e continuariam comprando pós-pandemia. Conclui-se que o ideal para a empresa estudada é adotar site e Instagram de forma complementar como meios de vendas. Sugere-se para pesquisas futuras a aplicação da ferramenta utilizada (questionário) em outras empresas do mesmo ramo com o intuito de auxiliar na escolha de um canal de vendas on-line que melhor se adeque à empresa e aos seus consumidores.
Palavras-Chave: Administração. Marketing digital. Canais de venda. Microempresa varejista. E-commerce.
Abstract: The article aims to analyze the feasibility of implementing online sales tools of products in a microcompany that operates in the retail business of clothing and accessories. The study was developed based on the theoretical framework regarding the marketing compound (Product, Price, Square and Promotion), focusing on the "P of Square" and e-commerce. Quantitative and qualitative in nature, the field research methodology was used, using the application of questionnaires to 178 clients, using the Google Forms tool. The results showed that 99% of the interviewees have access to the Internet daily, mainly through their mobile phones. Most of them have the habit of shopping over the internet through websites or through Instagram and have average confidence in online stores. Respondents consider it important to shop online in the Coronavirus pandemic period, which is why they point out that they would buy online in this context and continue to buy post-pandemic. It is concluded that the ideal for the company studied is to adopt website and Instagram in a complementary way as means of sales. It is suggested for future research the application of the tool used (questionnaire) in other companies in the same branch in order to assist in the choice of an online sales channel that best agrees with the company and its consumers.
Keywords: Management. Digital marketing. Sales channels. Retail micro company. E-commerce.
Control de inventario y su efecto en la rentabilidad de Sociedad Civil de Hecho Denominado Grupo Uscocovich, 2020
Authors: Macías-Chila Gema , Zambrano-Intriago María
Published: May 2022

El presente trabajo analiza el efecto del control de inventarios de acuerdo a sus políticas de devolución y su rentabilidad  en Sociedad Civil de Hecho Denominado Grupo Uscocovich durante el año 2020, el cual se dedica a la distribución de productos farmacéuticos.

El diseño que se empleó fue no experimental, transversal de tipo descriptivo. Se aplicó métodos de análisis-sintético e inductivo-deductivo, además de las técnicas de la entrevista y la observación en las que se tomaron como instrumentos la guía de entrevistas y el check list. La población objeto de estudio fue de 14 personas y 144  proveedores tomados al alzar de acuerdo a las políticas de devolución y el análisis de la información se procesó en Excel.

Los resultados obtenidos determinaron que la empresa debe mejorar su gestión en cuanto a la rotación del inventario considerando las fechas de caducidad y su rotación para minimizar pérdidas, este control mejoraría el margen de rentabilidad y a la toma decisiones al momento de adquirir determinados productos.

Palabras clave: inventario, control, rentabilidad, devolución.
Identifikasi Lokasi Gangguan Pada Penyulang Baugan ULP Denpasar Dengan Metode Naïve Bayes
Authors: Putri Riska Suryanti , Setiawidayat Sabar , Priyandoko Gigih
Published: May 2022

One of the problems in the distribution of electrical power is the identification of the location of the disturbance in the distribution network of pt pln. Several methods have been proposed to determine the location of the disturbance including the nearest neighbor method, impedance method and nave bayes method, in this study the author proposes the naïve bayes method. The naïve bayes method is a classification method based on simple probability and is designed to be used with the assumption that between one class and another class are not mutually dependent (independent). In the naïve bayes classification, the learning process is more focused on estimating probabilities. From the results of the experiment using 30 samples, the average error value for comparison of identification using the nave bayes method and the direct tracing method in identifying the location of disturbances in the buagan feeder was 0.86% with an average difference between the actual distance and the distance in the program of 30.9 meters. . The results of the comparative analysis using paired samples statistics showed no significant difference at 0.05. In the results of the comparative analysis using anova one way at 0.01 there is no significant difference. This study serves to narrow the direct line area for handling electrical disturbances on the 20 kv network, so that in the event of an electrical disturbance on the 20 kv network it does not take a long time in the process of identifying the location of the electrical disturbance.
Pengaturan Kecepatan Motor Induksi Tiga Fasa Menggunakan Spwm Inverter dan Kontrol Pid dengan Metode Hibrid Volt/Herzt Konstan-Sensor Arus
Authors: Rasyid Ramly , Muhammad Miftah , Rasyid Rahman R.
Published: May 2022

Three-phase induction motors are often used in every industry because three-phase induction motors are relatively cheap. On the three-phase induction motor in order to get a varied speed, one of the methods is the Three-Phase Induction Motor Speed Setting Using SPWM Inverter And Hybrid Volt/Herzt Constant-Sensor Current-Density PID Control in order to maintain the speed of the motor. This simulation was carried out with Matlab 2007 software. Induction motor speed performance set with a set point of 100 rad/detm 140 rad/sec, and 200 rad.det is a consecutive rise time of 0.002 seconds, 0.00116 seconds, and 0.006 seconds, a maximum overshoot of 5.4%, 1.25%, and 0.875% respectively and 0.1518 seconds, 0.1464 seconds, and 0.15 seconds respectively. The response torkanya values between 75 Nm, 90 Nm, and 100 Nm respectively, while the performance of the insulated current is very small
Could A1 Aplasia or Hypoplasia Affect the Morphology and Rupture Risk of Anterior Communicating Artery Aneurysm?
Authors: Park Sung Chan , Jung Na Young , Park Eun Suk , Kwon Soon Chan
Published: May 2022

Objective : Anterior communicating artery (Acom) aneurysm is one of the most common intracranial aneurysms, constituting approximately 30–35% of all aneurysm formation in the brain. Anatomically, the H-complex (the anatomic morphology of both A1 to A2 segments) is thought to affects the nature of the Acom aneurysm due to its close relationship with the hemodynamics of the vessel. Therefore, we investigated the relative risk factors of aneurysmal rupture, especially focusing on H-complex morphology of the Acom.Methods : From January 2016 to December 2020, a total of 209 patients who underwent surgery, including clipping and coiling for Acom aneurysm in our institution were reviewed. There were 102 cases of ruptured aneurysm and 107 cases of unruptured aneurysm. The baseline morphology of aneurysms was investigated and the relationship between the H-complex and the clinical characteristics of patients with Acom aneurysms was assessed.Results : Of the 209 patients, 109 patients (52.1%) had symmetrical A1, 79 patients (37.8%) had unilateral hypoplastic A1, and 21 patients (10.0%) had aplastic A1. The hypoplastic A1 group and the aplastic A1 group were grouped together as unilateral dominancy of A1, and were compared with the symmetrical A1 group. There was no significant difference in demographic characteristics and radiological findings of Acom aneurysms between two groups. However, when dichotomizing the patients into ruptured cases and unruptured cases, unilateral dominance of the A1 segment was associated with aneurysmal rupture with statistical significance (p=0.011).Conclusion : These results suggest that the unilateral dominance of the A1 segment does not have a significant effect on the morphology of Acom aneurysms, but contributes to aneurysmal rupture. Thus, we can better understand the effects of hemodynamics on Acom aneurysm.
Pengaruh Pemberian Vitamin dan Lysin pada Pakan terhadap Gonad Lobster Air Tawar Capit Merah (Cherax quadricarinatus)
Authors: Agusrinal Agusrinal , Tolanamy Emand Syapriawan , Septiantoro Ryan
Published: May 2022

ABSTRAKKeberhasilan budidaya lobster air tawar (LAT) sangat dipengaruhi oleh ketersediaan benih yang berkualitas dan pakan. Nutrisi mempunyai peran substansial dalam proses reproduksi. Lobster membutuhkan nutrisi pada pakan dalam bentuk energi dan asamamino esensial yang cukup, asam lemak essensial, spesifik vitamin dan mineral sehingga bisa memacu pertumbuhannya. Tujuan dari penelitian ini adalah untuk mengetahui perbedaan pertumbuhan pada gonad dan hepatopankreas lobster air tawar yang diberi makan dengan pakan yang mengandung vitamin dan lysin. Penelitian ini dilakukan dengan menggunakan indukan LAT sebanyak 12 ekor jantan dan 36 ekor betina yang dipelihara pada kolam berukuran 200 cm x 300 cm x 30 cm dan diberi pakan dengan pakan udang komersial. Vitamin yang digunakan yaitu Vitamin C dan E sedangkan lysin yang digunakan yaitu L-lysine HCL. LAT dipelihara dengan 4 perlakuan yakni Perlakuan A (kontrol, pakan komersial tanpa penambahan apapun), Perlakuan B (pakan komersial ditambah dengan 500 mg lysin/kg pakan), Perlakuan C ( pakan komersial ditambah dengan 500 mg vitamin/kg pakan) dan Perlakuan D ( pakan komersial ditambah dengan 250 mg lysin dan 250 mg vitamin/kg pakan ). Hasil penelitian menunjukkan bahwa nilai GSI tertinggi pada perlakuan D berkisar antara 2,144285 – 4,405363 dan yang terendah pada perlakuan C berkisar antara 0,86478 – 2,397525. Nilai HSI tertinggi pada Perlakuan D berkisar antara 5,67044696 – 6,8977591 dan yang terendah pada perlakuan C yaitu berkisar antara 2,96450151 – 3,05737542. Hal ini mengindikasikan bahwa pemberian 250 mg vitamin dan 250 mg lysin pada pakan dapat mempercepat kematangan gonad LAT secara optimal sehingga bisa meningkatkan produktivitas budidaya LAT capit merah.Kata Kunci: gonad; lobster air tawar capit merah; lysin; vitamin
PENGARUH SUBSTITUSI TEPUNG MIKROALGA Chlorella vulgaris PADA PAKAN BUATAN TERHADAP PERTUMBUHAN KEPITING BAKAU (Scylla serrata)
Authors: Yusran Yusran , Iba Wa , Abidin La Ode Baytul , Hamzah Muhaimin , Kurnia Agus
Published: May 2022

ABSTRAKPenelitian ini bertujuan untuk mengetahui pertumbuhan, kelangsungan hidup, efisiensi pakan dan retensi protein kepiting bakau (Scylla serrata) yang diberi pakan komersial dengan substitusi tepung mikroalga C. vulgaris (TMCv). Penelitian ini menggunakan 5 perlakuan yaitu substitusi pakan komersil dengan 0, 25, 50, 75, dan 100% TMCv. Kepiting bakau dengan berat awal berkisar pada 70-90 gram dipelihara selama 45 hari dengan kepadatan 1 ekor/ruang. Parameter yang diukur adalah tingkat kelangsungan hidup, laju pertumbuhan spesifik, pertumbuhan mutlak, rasio konversi pakan, efisiensi pakan, dan kualitas air. Tingkat kelangsungan hidup kepiting bakau adalah 100% pada semua perlakuan.  Laju pertumbuhan spesifik, pertumbuhan mutlak, rasio konversi pakan, dan  efisiensi pakan kepiting bakau menunjukkan hasil yang lebih baik pada perlakuan pakan 100% TMCv dibandingkan dengan pakan 0, 25, 50, 75% TMCv. Perlakuan 0% TMCv atau pakan komersil 100% mendapatkan nilai terendah dari seluruh parameter yang diamati. Penelitian ini mengindikasikan bahwa pemberian pakan 100% TMCv sangat efisien dibandingkan dengan menggunakan pakan komersial atau pakan substitusi TMCv untuk pertumbuhan kepiting bakau. Kata kunci: Chlorella vulgaris, kepiting bakau, pertumbuhan
Ikan Kepait Dari Selatan Pulau Bangka Sebagai Kandidat Spesies Baru Berdasarkan Meristik Dan Gen Sitokrom b
Authors: Kurniawan Ardiansyah , Syarif Ahmad Fahrul
Published: May 2022

AbstrakIkan Kepait merupakan salah satu ikhtiofauna yang ditemukan keberadaannya di Pulau Bangka. Ikan lokal yang juga ditemukan di selatan Pulau Bangka ini memerlukan diidentifikasi secara morfologi dan molekuler untuk memastikan taksonominya. Eksplorasi sampel ikan dilakukan di Desa Bencah, Kecamatan Air Gegas, Kabupaten Bangka Selatan. Pengamatan karakter morfologi meliputi ciri fisik dan meristik, sementara identifikasi molekuler menggunakan gen sitokrom b. Morfologi ikan menunjukkan kemiripan dengan Osteochilus spilurus pada terdapatnya bulatan besar pada pangkal ekor, linealateralis pada 29 -31 sisik, predorsal scale pada sisik ke 8-9, formula sirip dorsal D iii.12-13 dan sirip anal A.6. Namun terdapat perbedaan pada membran sirip berwarna kemerahan dan jumlah sisik linealateralis. Karakterisasi DNA gen sitokrom b menghasilkan nukleotida dengan panjang  1136 bp menunjukkan perbedaan cabang dengan Osteochilus spilurus dari  pulau yang sama pada konstruksi pohon filogenetik dengan jarak genetik lebih dari 20%. Kondisi ini memungkinkan sampel ikan dari selatan Pulau Bangka ini menjadi kandidat spesies baru dalam genus Osteochilus.Kata kunci : Osteochilus spilurus, spesies baru, Bangka Selatan, Sitokrom b.
Necip Fazıl ve Yunus Emre Şiirlerinde Görülen “Tezat” Düşüncesi ve Benzerlikler: Hakikate Kritik Analitik Yaklaşım
Authors: ATAMAN Kemal Yavuz
Published: May 2022

Yunus Emre tarihe mal olmuş, aşk ve gönül ehli, mutasavvıf, şairdir. Şiirleri etkili, içli, duygulu, anlamlı, düşündürücüdür. Asırlardır etkisi süregelen şiirlerinde bazen tezat (karşıt) düşüncelere yer vererek doğruyu, hakikati güçlü bir tarzda ifade eder. Dertli, hüzünlü, çilekeş haliyle, halktan her kesimin anlayacağı şiir dilini, saf, arı, duru Türkçe ile kullanır, kabul görür. Kişiden topluma yönelen yapıcı, sevgi temelli uslubuyla insanları hakikate, İlahi Aşk’a çağırır. Necib Fazıl yaşadığı çağın, insanlığın, sistemlerin, ülkenin, toplumun bunalım, buhran ve sorunlarıyla, çalkantılarla yaşar, arayış içindedir, İslam’a yönelir, tasavvufla, bir Mürşid-i Kamil ile buluşur. Çarpık anlayışlara, yapılara meydan okur. Şiir dili anlaşılır, akıcı, sadedir. Toplumun günlük kullandığı kelimeleri seçer. Akla gelmeyen şekilde ve manalarla kelimelere birkaç yükler. Aşk, şevk, heyecan, hareket, coşku, sevgi ve samimiyet şiirlerinde açıkça görülür. Sanatını maharetle, ustalıkla, cesaretle kullanarak zihinleri, akılları kalpleri, kitleleri harekete geçirir.Her iki şahsiyetin tezat ( karşıtlık) sanatını kullanarak açık,seçik, net, belirgin, doğru bir şekilde hakikati ifade ettikleri görülür. Kritik Analitik Düşünme açık, mantıklı, tutarlı,doğru, güvenilir,etkili,ikna edici bileşenler üzerine bina edilir. Söz konusu bileşenler her iki mümtaz şahsiyetin şiirlerinde yer alır. Şiirler İslam inancına, varoluş sırrına, yaratılış gerçeği üzerine bina edilir. Sağduyu sahibi duruşları, çizgileri düşüncelerinin doğruluğunu teyit eder. Bu nedenle hakikat vurgusu muhataplarında kamilen karşılık bulur. Tezat (zıtlık-karşıtlık) düşüncesinin birlikte verildiği mısralar, kişiye doğrudan tesir eder. Tezat, varoluşun, yaratılışın, hakikatin asli unsuru ve hikmetidir. “Tezat”, gece-gündüz, iyi-kötü, mümin-kafir, melek-şeytan, Cennet- Cehennem gibi varlıklar, kavramlar, olaylar Kuran’da çokça zikredilir. Bu yöntem Yaratıcı’nın kullara çağrısında kullanılır. Zıddı olmayan tek varlık, hakikat Allah
Ali Şir Nevâyî’nin Toplumsal Meselelere Kritik Analitik Bakışı
Authors: Boltabayev Saidbek
Published: May 2022

Şiir aleminin sultanı olarak nitelendirilen Ali Şir Nevâyî (M. 1441-1501) yazdığı eserleriyle Türk edebiyatını yeni bir aşamaya yükseltmiştir. Timurlu Rönesansının son, aynı zamanda en seçkin temsilcilerinden biri olan Nevâyî, sanat alanındaki faaliyetleri, devlet görevleri ve toplumsal faaliyetlerinin yanı sıra büyük bir düşünür olarak ön plana çıkmaktadır. O çalışma hayatında doğrudan siyasi ve toplumsal görevleri üstlenmiş, vakıflar kurmuş, bütün malvarlığını bu yönde harcamıştır. Hüseyin Baykara’nın çocukluktan itibaren dostu ve en çok güvendiği kişi olması sebebiyle devlet görevlerine getirilmiş, siyasi kişiler ve devlet adamlarını iyi tanımıştır. Şiirleri dışında topluma, ilme, sanata verdiği değer onun toplum tarafından sevilmesine sebep olmuş, şair daima toplumla iç içe olmuştur. Bu sebeple Nevâyî kaleme aldığı eserlerinde yaşadığı dönemin dikkate değer meselelerini de dile getirmiş, bu meselelerin çözüme kavuşması için kritik analitik bakışlarını ifade etmiştir. Üstelik onun bu düşünceleri yeri geldiğinde alegorik ve mecazî anlatımla aktarılmış, şairin ideal insan, ideal devlet ve ideal toplum konusundaki düşüncelerini yansıtmıştır. Bu sebeple Nevâyî’nin bıraktığı miras sadece ilmî ve edebî bakımdan değil, aynı zamanda sosyal meseleler yönünden de değerlidir.
Exosome Mimetics-Loaded Hydrogel Accelerates Wound Repair by Transferring Functional Mitochondrial Proteins
Authors: Zhu Jie , Liu Zhixiao , Wang Ling , Jin Qishu , Zhao Yunpeng , Du Antong , Ding Neng , Wang Yue , Jiang Hua , Zhu Lie
Published: May 2022

Loading human umbilical mesenchymal stem cell (hUMSC) derived exosomes onto hydrogel scaffolds is a strategy for rapid wound healing. The clinical application of exosomes is hindered by low production, and exosome mimetics could be substituted for exosomes. Here, the therapeutic effects of exosome-loaded hydrogels and exosome mimetic-loaded hydrogels on wounds are evaluated. Our results revealed that exosome mimetic-loaded hydrogels promote wound healing more efficiently than exosome-loaded hydrogels. Exosome mimetics can promote the proliferation and migration of dermal fibroblasts (hDF-a) cells in vitro. To investigate how exosome mimetics play a role, proteomics analysis was applied, and the obtained results suggested that exosome mimetics significantly enrich mitochondrial-derived oxidative phosphorylation-related proteins in comparison to exosomes. Overall, our work envisages the emerging potential of exosome mimetics, which take the advantage of exosomes and can be promising candidates for exosomes. It also suggests that hUMSC-derived exosome mimetic-loaded hydrogels have remarkable prospects for clinical application.
Metal Ion-Based Supramolecular Self-Assembly for Cancer Theranostics
Authors: Chen Bing , Chu Chengchao , Ren En , Lin Huirong , Zhang Yang , Wang Peiyu , Yao Hong , Liu Ailin , Liu Gang , Lin Xinhua
Published: May 2022

Metal-ion-based self-assembly supramolecular theranostics exhibit excellent performance in biomedical applications owing to their potential superiorities for simultaneous precise diagnosis, targeted drug delivery, and monitoring the response to therapy in real-time. Specially, the rational designed systems could achieve specific in vivo self-assembly through complexation or ionic interaction to improve tissue-specific accumulation, penetration, and cell internalization, thereby reducing toxicities of drugs in diagnostics and therapy. Furthermore, such imaging traceable nanosystems could provide real-timely information of drug accumulation and therapeutic effects in a non-invasive and safe manner. Herein, the article highlights the recent prominent applications based on the metal ions self-assembly in cancer treatment. This strategy may open up new research directions to develop novel drug delivery systems for cancer theranostics.
In Vitro Hepatoprotective and Human Gut Microbiota Modulation of Polysaccharide-Peptides in Pleurotus citrinopileatus
Authors: Huang Yihua , Gao Yi , Pi Xionge , Zhao Shuang , Liu Wei
Published: May 2022

Pleurotus citrinopileatus, a golden oyster mushroom, is popular in Asia and has pharmacological functions. However, the effects of polysaccharide-peptides extracted from Pleurotus citrinopileatus and underlying mechanism on digestive systme have not yet been clarified. Here, we determined the composition of two polysaccharide-peptides (PSI and PSII) from P. citrinopileatus and investigated the protective effects of on hepatoprotective and gut microbiota. The results showed that PSI and PSII were made up of similar monosaccharide moieties, except for the varying ratios. Furthermore, PSI and PSII showed that they have the hepatoprotective effects and significantly increased the viabilities and cellular total superoxide dismutase activities increased significantly in HepG2 cells. Intracellular triglyceride content and extracellular alanine aminotransferase and aspartate transaminase contents markedly decreased following treatment with 40 and 50 μg/mL PSI and PSII, respectively. Moreover, PSI and PSII activated the adiponectin pathway and reduced lipid accumulation in liver cells. PSI and PSII elevated short-chain fatty acid concentrations, especially butyric and acetic acids. 16S rRNA gene sequencing analysis showed that PSI promoted the relative abundances of Bifidobacteria, Lactobacillus, Faecalibacterium, as well as Prevotella generas in the gut. PSII markedly suppressed the relative abundances of Escherichia-Shigella and Bacteroides generas. We speculate that the PSI and PSII play a role through liver-gut axis system. Polysaccharide-peptides metabolize by gut microbiota to produce short-chain fatty acids (SCFAs) and in turn influence liver functions.
Anti-Influenza Effect and Mechanisms of Lentinan in an ICR Mouse Model
Authors: Cui Huan , Zhang Cheng , Zhang Chunmao , Cai Zhuming , Chen Ligong , Chen Zhaoliang , Zhao Kui , Qiao Sina , Wang Yingchun , Meng Lijia , Dong Shishan , Liu Juxiang , Guo Zhendong
Published: May 2022

Influenza virus is a serious threat to global human health and public health security. There is an urgent need to develop new anti-influenza drugs. Lentinan (LNT) has attracted increasing attention in recent years. As potential protective agent, LNT has been shown to have anti-tumor, anti-inflammatory, and antiviral properties. However, there has been no further research into the anti-influenza action of lentinan in vivo, and the mechanism is still not fully understood. In this study, the anti-influenza effect and mechanism of Lentinan were studied in the Institute of Cancer Research (ICR) mouse model. The results showed that Lentinan had a high degree of protection in mice against infection with influenza A virus, delayed the emergence of clinical manifestations, improved the survival rate of mice, significantly prolonged the middle survival days, attenuated the weight loss, and reduced the lung coefficient of mice. It alleviated the pathological damage of mice infected with the influenza virus and improved blood indices. Lentinan treatment considerably inhibited inflammatory cytokine (TNF-α, IL-1β, IL-4, IL-5, IL-6) levels in the serum and lung and improved IFN-γ cytokine levels, which reduced cytokine storms caused by influenza virus infection. The underlying mechanisms of action involved Lentinan inhibiting the inflammatory response by regulating the TLR4/MyD88 signaling pathway. This study provides a foundation for the clinical application of Lentinan, and provides new insight into the development of novel immunomodulators.
Clinical-Epidemiology Aspect of Inpatients With Moderate or Severe COVID-19 in a Brazilian Macroregion: Disease and Countermeasures
Authors: Silva Bruna Raphaela Oliveira , Rodrigues Wellington Francisco , Abadia Daniela Gomes Pires , Alves da Silva Djalma A. , Andrade e Silva Leonardo E. , Desidério Chamberttan S. , Farnesi-de-Assunção Thais Soares , Costa-Madeira Juliana C. , Barbosa Rafaela M. , Bernardes e Borges Anna V. , Hortolani Cunha Andrezza C. C. , Pereira Loren Q. , Helmo Fernanda R. , Lemes Marcela Rezende , Barbosa Laís M. , Trevisan Rafael O. , Obata Malu Mateus Santos , Bueno Giovanna F. , Mundim Fabiano V. , Oliveira-Scussel Ana Carolina M. , Monteiro Ivan B. , Ferreira Yulsef M. , Machado Guilherme H. , Ferreira-Paim Kennio , Moraes-Souza Hélio , da Silva Marcos Vinicius , Rodrigues Júnior Virmondes , Oliveira Carlo José Freire
Published: May 2022

COVID-19, also known as coronavirus disease 2019, is an infectious viral disease caused by SARS-CoV-2, a novel coronavirus. Since its emergence, its epidemiology has been explored; however, for some regions of the world, COVID-19’s behavior, incidence, and impact remain unclear. In continental nations like Brazil, this lack of knowledge results in nonuniform control, prevention, and treatment measures, which can be controversial in some locations. This study aimed to describe the epidemiological profile of patients with COVID-19 in the macroregion of Triângulo Sul in the state of Minas Gerais (MG), Brazil. Between March 25 and October 21, 2020, data were collected and statistically analyzed from 395 hospitalized patients in the city of Uberaba, MG, suspected to have moderate or severe forms of the disease. Of the 395 suspected cases, 82% were confirmed to be positive for COVID-19. The mean age of positive patients was 58.4 years, and 60.76% were male. Following these patients throughout their hospitalization, a mortality rate of 31.3% was observed. In the population positive for COVID-19, the risk of death increased by 4% for each year of the patient’s age. Likewise, the older the patient, the longer their hospitalization and the higher the risk of developing acute respiratory failure. Among the treatments tested in patients, heparin was associated with protection against mortality, and the absence of anticoagulant use was linked to a more than six times greater risk of death. Finally, comorbidities in patients with COVID-19 were positively correlated with increased hospitalization time. In summary, this study revealed that age, presence of comorbidities, length of hospitalization, and drug treatment considerably altered COVID-19’s lethality. To understand infection rates and the factors involved in COVID-19’s lethality, knowledge of the local epidemiology is necessary.
Snakes, Sharks, and the Great Barrier Reef: Selected Use of Anglicisms to Represent Australia in the Australian German-Language Newspaper, Die Woche
Authors: Hunt Jaime W.
Published: May 2022

Much research into language contact, specifically on anglicisms in German, investigates the appearance and use of English borrowings in the print media published in Germany, Austria, or Switzerland. While these publications are intended for a German-speaking audience in majority German-speaking countries, it remains to be explored what happens to English loans when they appear in a German-language publication produced in a majority English-speaking country. This raises questions about how the local environment, issues and events related to the country of publication are represented lexically to a local audience who are familiar with these concepts in English. Using both quantitative and qualitative methods, I analyze a selection of anglicisms related to Australia in a corpus of 25,147 types and 223,671 tokens from the Australian-published German-language newspaper Die Woche. The findings indicate that most of these anglicism types occur within the semantic fields of place and society. The frequency and distribution of various types, such as adapted and unadapted borrowings, loan translations and loan renditions, including flagged lexical units and codeswitching, appears to be determined mostly by authorship and intended audience of individual articles rather than the newspaper as a whole. Articles attributed to the dpa (Deutsche Presse-Agentur “German Press Agency”) contain a higher incidence of loan translations, loan renditions, and flagging devices, particularly of proper nouns, than those attributed to local journalists. While this may allow international readers of the articles distributed via the dpa to better understand Australian events, institutions, social phenomena, and place, it may have a distancing or even alienating effect for local German speakers, situating them outside mainstream Australian society.
Clinical Characteristics and Long-Term Outcomes of MINOCA Accompanied by Active Cancer: A Retrospective Insight Into a Cardio-Oncology Center Registry
Authors: Stepien Konrad , Nowak Karol , Szlosarczyk Barbara , Nessler Jadwiga , Zalewski Jaroslaw
Published: May 2022

Background

Clinical characteristics and long-term outcomes of patients with myocardial infarction with non-obstructive coronary arteries (MINOCA) and cancer are insufficiently elucidated.

Objectives

We sought to characterize these patients hospitalized in a tertiary cardio-oncology center and to find the potential determinants affecting their long-term mortality.

Methods

MINOCA was diagnosed in 72 of the 1,011 patients with consecutive myocardial infarction who underwent coronary angiography. Mortality rates and their determinants were analyzed within a median follow-up of 69.2 (37.8–79.9) months.

Results

Active cancer was identified in 21 (29.2%) of patients with MINOCA and in 113 (12.0%) patients with myocardial infarction and obstructive coronary artery disease (MI-CAD) (p < 0.001). MINOCA patients with cancer were characterized by a higher incidence of anemia (47.6 vs. 21.6%, p = 0.03) and more frequently Takotsubo syndrome (19.1 vs. 2.0%, p = 0.01) than in non-cancer MINOCA. The troponin T/hemoglobin ratio was higher in both cancer MINOCA and MI-CAD groups when compared with their respective non-cancer patients (both p < 0.05). The age and sex-standardized mortality rates were significantly higher in cancer MINOCA (26.7%/year) when compared with non-cancer MINOCA (2.3%/year, p = 0.002) and in cancer MI-CAD (25.0%/year) vs. non-cancer MI-CAD (3.7%/year, p < 0.001). Active cancer (HR 3.12, 95% CI 2.41–4.04) was independently associated with higher long-term mortality, while higher hemoglobin levels (HR 0.93, 95% CI 0.88–0.99, per g/dl) and a MINOCA diagnosis (HR 0.69, 95% CI 0.47–0.97) improved long-term survival.

Conclusion

Patients with MINOCA were comorbid with cancer more frequently than MI-CAD. In turn, an active malignancy was associated with an unfavorable long-term survival both in MI-CAD population and in patients with MINOCA.
Case Report: Danon Disease: Six Family Members and Literature Review
Authors: Wang Yuanyuan , Jia Meixue , Guo Yingjie , Zhang Ting , Ning Bin
Published: May 2022

Danon disease is a rare X-linked dominant genetic disorder that manifests with a clinical triad of cardiomyopathy, skeletal myopathy, and intellectual disability. It is caused by mutations in the lysosome-associated membrane 2 (LAMP2) gene. We report one case of Danon disease and his family members, characterized by ventricular pre-excitation, ventricular hypertrophy, abnormal muscle enzymes, and aberrant liver function. All the patients were confirmed to have Danon disease through genetic screening. Relevant literature was reviewed as a reference for the diagnosis and treatment of the disease.
Podocan and Adverse Clinical Outcome in Patients Admitted With Suspected Acute Coronary Syndromes
Authors: Andersen Thomas , Ueland Thor , Aukrust Pål , Nilsen Dennis W. , Grundt Heidi , Staines Harry , Kontny Frederic
Published: May 2022

Background

Markers of bone and extracellular matrix (ECM) remodeling may be associated with adverse outcomes in atherosclerotic cardiovascular disease. Podocan is a newly discovered ECM glycoprotein, previously not studied in a chest pain population. We wanted to study the association between Podocan levels on admission and the risk of adverse outcomes in a chest pain population with suspected acute coronary syndromes.

Methods

A total of 815 patients from the Risk markers in Acute Coronary Syndrome (RACS) trial with suspected coronary chest pain were followed for 7 years. Blood samples were taken immediately after inclusion and stored in the biobank. Associations between Podocan and endpoints were assessed with Cox proportional hazards analyses.

Results

The median admission level of Podocan was 0.674 ng/ml (0.566–0.908 ng/ml). No significant association was found between Podocan quartile levels and all-cause death, neither at 1 year nor 2- or 7-years follow-up (p> 0.05 for all). Furthermore, no significant association could be shown between Podocan and cardiac death, myocardial infarction (MI), stroke, or the composites of all-cause death/MI/stroke or cardiac death/MI/stroke (p> 0.05 for all). Similarly, in a subgroup of patients with Troponin T-positive (n= 432) there was no significant association between Podocan and any of the outcome measures (p> 0.05 for all endpoints and points in time).

Conclusion

Podocan, a novel ECM biomarker, is not associated with all-cause mortality or other major cardiovascular adverse events in patients admitted with acute chest pain suspected to be of coronary origin.

Clinical Trials.gov Identifier:

NCT00521976.
Contrast-Enhanced Ultrasonography Enables the Detection of a Cold Pressor Test-Induced Increase in Renal Microcirculation in Healthy Participants
Authors: Hendriks-Balk Mariëlle C. , Damianaki Aikaterini , Polychronopoulou Erietta , Brito Wendy , Pruijm Menno , Wuerzner Gregoire
Published: May 2022

Background

Renal microcirculation is essential for regulation of the glomerular filtration rate, the reabsorption of salt and water from the interstitium, and hence the blood pressure. Renal ultrasonography coupled to Doppler analysis and contrast-enhanced ultrasound enables the study of renal perfusion. So far, physiologic interventions have rarely been performed to assess the renal perfusion. The objective of our study was to measure the renal perfusion in response to a cold pressor test (CPT).

Methods

Healthy adult participants were exposed to a 2 min CPT or a sham exposure (body temperature). Systemic hemodynamics, renal resistive index (RRI) and renal perfusion index (PI) were measured before and during the CPT or the sham exposure. Renal responses were compared using a paired Student's t-test or Wilcoxon signed rank test. Pearson correlation test was used to test association of variables of interest.

Results

Forty-one normotensive participants (21 women) were included in the study. Mean blood pressure and heart rate both increased with the CPT. The RRI decreased from 0.60 ± 0.05 arbitrary units (AU) to 0.58 ± 0.05 AU (p < 0.05) and the PI increased from 2,074 AU (1,358–3,346) to 3,800 AU (2,118–6,399) (p < 0.05) (+66% (24–106%)). Compared to the sham exposure, the increase in PI with the CPT was more marked. There was a negative association between the increase in heart rate and mean blood pressure with the RRI (r: −0.550, p = 0.002 and r: −0.395, P = 0.016), respectively.

Conclusion

Doppler Ultrasound and CEUS enable the detection of physiological changes within the macro- and microvascular renal circulation. The CPT decreases the RRI and increases the PI. Whether these changes are present in pathological states such as diabetes or hypertension will need additional studies.
Causes of Tunnel Diseases in a Karst Stratum and Remediation Measures: A Case Study
Authors: Jiajia Shen , Hu Zhang , Li Wan , Changan Zhang , Xing Shao , Zanquan Lin , Jie Song
Published: May 2022

Highway tunnels operated in karst areas are prone to serious structural diseases such as water–mud inrush, lining tension and cracks, and road humps. This article reviews the historical diseases of the tunnel based on the Nanshibi Tunnel project. The cause analysis of the structural diseases of Nanshibi Tunnel was performed on the basis of a refined geophysical prospecting scheme for the complex karst geological structure environment. A series of comprehensive treatments were conducted to address the tunnel diseases in the karst area. The treatments included surrounding rock grouting, lining replacement, and adding inverted arches. The results show that the refined geophysical prospecting scheme and disease remediation idea for the complex karst geological structure environment proposed herein can realize the full coverage and accurate detection of karst structures, water passage, and tunnel-lining diseases. The proposed scheme can effectively solve the technical problems of karst tunnel diseases that occur repeatedly and are difficult to be completely rectified. Finally, specific engineering practice suggestions were proposed for tunnel disease remediation in the karst area.
The Association Between Metabolic Syndrome and Prostate Cancer Risk: A Large-Scale Investigation and Study of Chinese
Authors: Gao Xiaoshuai , Li Ruicen , Jin Tao , Tang Huairong
Published: May 2022

Background

To investigate the association between metabolic syndrome (MetS) and its components and prostate cancer (PCa).

Methods

This study enrolled 482 943 consecutive men who underwent routine health checkups at the Health Management Center of West China Hospital Between 2010 and 2017. For patients with elevated prostate-specific antigen (PSA) levels or color Doppler ultrasound indicating abnormal prostates, we recommended prostate puncture and follow-up. We used the chi-square test and independent t-test for categorical variables and continuous variables, respectively. We used logistic regression analysis to evaluate the effects of MetS and its components on prostate cancer risk.

Results

We found that the incidence of PCa in Chinese men over 40 years of age was 0.1%. Among the 85882 participants, 31.5% (27016/85882) of the patients were diagnosed with MetS. PCa was associated with older age, higher PSA levels, lighter weight and shorter height, hypertension, elevated fasting blood glucose (FBG) and HDL cholesterol level, lower triglycerides. After excluded the interference of other factors in multivariate logistic analysis, we found that MetS, hypertension, hyperlipidemia, hyperglycemia, and obesity were not related to the risk of PCa. High age and PSA levels were risk factors for prostate cancer.

Conclusions

High age and PSA levels were risk factors for prostate cancer. MetS, hypertension, hyperlipidemia, hyperglycemia, and obesity were not related to the risk of PCa.
Value of Information and Decision Pathways: Concepts and Case Studies
Authors: Glynn Pierre D. , Rhodes Charles R. , Chiavacci Scott J. , Helgeson Jennifer F. , Shapiro Carl D. , Straub Crista L.
Published: May 2022

Information used in decision making arises from the structuring of observations and data. The collection, dissemination, and use of information has monetary and non-monetary costs (e.g., competition for attention) and necessitates trade-offs. Understanding the benefits of having information (i.e., the value of information, VOI), including resulting societal outcomes, is useful to information producers/funders and decision makers. Using theory, use cases, and hypotheticals, we describe how information (e.g., geospatial information) is valued and incorporated in decisions and actions related to managing natural resources, environments, and the impacts of natural and anthropogenic hazards. We discuss the nature of information and how it relates to models (conceptual, mental, scientific), beliefs, knowledge, and economic analyses. VOI approaches and behavioral factors that potentially affect information use and value are summarized. Framing of information and VOI through data to decision pathways (DDPs) at first simplifies understanding, then illustrates the benefits of information, and the human and societal challenges encountered in valuing and using it. We present approaches to overcome these challenges. Our transdisciplinary analysis concludes with a summary of critical issues affecting DDPs and VOI, and suggestions for improving both economic analyses and the actionability and use of information.
First Report of the Hyperaccumulating Potential of Cadmium and Lead by Cleome rutidosperma DC. With a Brief Insight Into the Chemical Vocabulary of its Roots
Authors: Bhattacharya Ekta , Mandal Biswas Suparna
Published: May 2022

Phytoremediation is gaining interest in recent years as it is a simple and effective strategy for heavy metal decontamination. The most straightforward strategy for successful heavy metal clean-up is searching for efficient hyperaccumulator species that grow naturally in contaminated sites. The present study, therefore, is the first detailed account of hyperaccumulator potentialities of a neglected and underutilized (NUS) species, Cleome rutidosperma DC. Hydroponic screening experiment against cadmium and lead revealed that even at 10 mg/kg concentration, it could accumulate 42.49 mg/kg of Cd and 27.79 mg/kg of Pb in shoots, while it could accumulate 134.71 mg/kg Cd and 491.35 mg/kg of Pb in its roots, and these values were significantly higher than those of the control plants. This plant could efficiently accumulate as high as 639.07 mg/kg of Cd, 8,726.03 mg/kg of Pb in its roots, while it could accumulate 752.83 mg/kg Cd and 3,732.64 mg/kg Pb in its shoots as evident from the pot experiments. In the case of Cd, there was no significant effect of toxicity on the phytophysiological parameters. But increasing concentrations of Pb did have toxic effects on the total chlorophyll content. This plant showed to have a BCF >1 in most of the tested concentrations. At the highest treatment concentration, however, both the BCF and TF were found to be greater than 1. This indicated that C. rutidosperma can accumulate and translocate the heavy metals to its aerial parts when the metal concentration is extremely high, proving itself to be an efficient hyperaccumulator. In order to decode the chemical signals, this plant may emit through the roots to cope with stress; root exudates were collected, purified, and analyzed through GCMS. This revealed the presence of five major compounds, namely, palmitic acid, linoleic acid, oleic acid, campesterol, and stigmasterol, which mainly are metabolic markers for detoxification mechanisms triggered by various stresses. Therefore, based on this study, C. rutidosperma can be termed a potent hyperaccumulator and can further be exploited for remediation of other classes of environmental pollutants.
Predicting a Suitable Distribution Pattern of Dominant Tree Species in the Northwestern Sichuan Plateau Under Climate Change and Multi-Scenario Evaluation of Carbon Sink Potentials
Authors: Wang Guangjie , Han Xuemei , Yang Chen , Qian Jiangcheng
Published: May 2022

Climate change threatens the global living environment, and afforestation-based carbon sequestration is an effective measure to relieve and adapt to climate changes. In this study, the ideal distribution patterns of Abies, Picea, Quercus, and Betula species in forests in Mao County, China, were simulated and predicted, respectively, using the maximum entropy niche model, MaxEnt. Afterward, suitable distribution patterns of the four dominant tree species under different scenarios were simulated by overlaying suitable distribution areas for each species. Subsequently, the total carbon sinks of the suitable distribution patterns were estimated by combining the biomass expansion factors (BEFs). The optimal scenario for carbon sequestration was found by comparing the total carbon sinks under different scenarios. By comparing the results with existing forest resources in Mao County, the maximum increase of the carbon sink potential was estimated. The results demonstrated the following: 1) the MaxEnt model has a good simulation effect and the average AUC of the four tree species is higher than 0.8, indicating that the potential distribution areas of the dominant tree species have relatively high accuracy in model simulation. 2) The suitable area size order of the four dominant tree species is Picea > Abies > Betula > Quercus. The total suitable area is 295,593.28ha. The order of biomass of the four tree species per unit area is Abies > Betula > Picea > Quercus. 3) When it is suitable to plant multiple tree species simultaneously, the planting combination mode of the trees was chosen according to biomass to obtain maximum carbon reserves. The carbon reserve of this combination mode was 15.81 Tg C. 4) Compared with existing forest resources, the maximum carbon reserve potential of the four dominant tree species can increase to 2.13 Tg C in the future. In this study, suitable distribution patterns and carbon sink potentials of the four dominant tree species in the northwestern Sichuan Plateau were analyzed and predicted. The results provided a reference for afforestation plans, tree species selection, and regional distribution layouts for future carbon sequestration projects in the plateaus. The study is beneficial for increasing economic benefits and the ecological value of forest carbon sinks in plateaus.
Interactions Between Fire Refugia and Climate-Environment Conditions Determine Mesic Subalpine Forest Recovery After Large and Severe Wildfires
Authors: Busby Sebastian U. , Holz Andrés
Published: May 2022

Infrequent stand-replacing wildfires are characteristic of mesic and/or cool conifer forests in western North America, where forest recovery within high-severity burn patch interiors can be slow, yet successful over long temporal periods (decades to centuries). Increasing fire frequency and high-severity burn patch size, under a warming climate, however, may challenge post-fire forest recovery, promoting landscape-level shifts in forest structure, composition, and distribution of non-forest patches. Crucial to a delay and/or impediment to this shift, fire refugia (i.e., remnant seed sources) may determine forest recovery trajectories and potential forest state-transitions. To examine how fire refugia attributes (i.e. extent, composition, and structure) interact with local climate and environmental conditions to determine post-fire forest recovery responses, we developed fine-grain maps of fire refugia via remote sensing and conducted field-based assessment of post-fire conifer tree establishment largely originating (i.e., dispersed) from fire refugium in the Central Cascade Range of the Pacific Northwest United States. We found that limitations on seed availability, represented by the distance2-weighted density (D2WD) of fine-grain refugia extent, largely explained post-fire tree establishment responses within our relatively mesic and cool subalpine study sites. Interactions between seed availability, climate, and environmental conditions indicated that the structural attributes of refugia (e.g., tree height) and site abiotic/biotic environmental controls (e.g., climate water deficit, canopy cover, and coarse woody debris cover) interplayed to constrain or enhance species-specific tree establishment responses. Importantly, these interactions illustrate that when seed availability is critically low for a given area, climate-environment conditions may strongly determine whether forests recover following fire(s). Toward modelling and predicting tree establishment responses and potential forest state-transitions after large stand-replacing fires(s), our study demonstrates the importance of accurately quantifying seed availability via the fine-grain extent, configuration, and attributes of remnant seed source legacies.