bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlation between Periodontitis and Onset of Alzheimer’s Disease: A Literature Review
Authors: Barbarisi Antonio , Visconti Valeria , Lauritano Dorina , Cremonini Francesca , Caccianiga Gianluigi , Ceraulo Saverio
Published: October 2024

Background: Alzheimer’s disease is a slowly progressing neurodegenerative illness and the most common form of dementia. This pathology leads to an increase in cognitive decline and is responsible, in patients, for several difficulties in performing various activities of daily living, such as oral hygiene. Several experimental studies have shown that oral health in patients with Alzheimer’s disease worsens in direct proportion to the progression of the disease due to the appearance of gingivitis and periodontitis. Methods: This clinical literature review aims to evaluate a possible correlation between periodontal disease and Alzheimer’s disease, trying to understand if the periopathogens can contribute to the onset or the progression of Alzheimer’s disease (AD). The study was conducted on the database PubMed (MEDLINE) of full-text systematic reviews in English on humans and animals that were published in the last five years, from 2018 to 2023. This returned 50 publications, which, once the eligibility criteria were applied, resulted in the 10 publications examined in this review. The selected articles were organized through the construction of tables, analyzed, and compared through Judith Garrard’s Matrix method to arrive at the review results. Results: Infection by periopathogens can increase the risk of developing Alzheimer’s disease, but also the onset of the latter can make it more difficult to maintain proper oral hygiene, favoring the onset of periodontal disease: it is possible to affirm the existence of a correlation between periodontitis and AD. It was found that patients exposed to chronic periodontitis have a greater risk of developing a cognitive decline or AD and that oral pathogens can be responsible for neuropathologies and increasing systemic inflammation. Conclusions: Periodontitis and periodontal pathogens represent a real risk factor for the onset or worsening of AD; however, the pathogenetic mechanism is still not completely clear.
The Harmful Effects of Welding Fumes on Human Dental Enamel—A Microhardness Analysis
Authors: Petrovici Catrinel Ștefania , Grăjdeanu Răzvan Alexandru , Petcu Adina , Vasile Monica , Severin Beatrice Marcela , Petrovici Doru Florin , Petcu Lucian Cristian
Published: October 2024

Introduction: Over the years, welding fumes’ harmful effects have been demonstrated countless times in the scientific literature. Recently, studies in the field have shown an increasing interest in the negative consequences that these fumes may have on the tissues of the oral cavity. Materials & method: The current study aimed to investigate the impact that welding fumes have on the structure of human dental enamel by analyzing the microhardness of the dental enamel in 15 extracted human teeth, after various exposure times, using the Vickers method. Results: The results obtained after 48, 96, 168, and 336 h of direct exposure of the extracted specimens to the welding fumes show a statistically significant increase in the depreciation of the dental enamel’s microhardness, related to the duration of exposure (p < 0.05). An average of 305 Vickers units was observed at the longest exposure time, 336 h, in the present study, whereas in the control group, the microhardness analysis showed an average of 327 Vickers units.
Dynamic Modeling of Distribution Power Systems with Renewable Generation for Stability Analysis
Authors: Madjovski Darko , Dumancic Ivan , Tranchita Carolina
Published: October 2024

This paper presents a comprehensive study on the dynamic modeling of distribution power systems with a focus on the integration of renewable energy sources (RESs) for stability analysis. Our research delves into the static and dynamic behavior of distribution systems, emphasizing the need for enhanced load modeling to mitigate planning and operational uncertainties. Using MATLAB/Simulink®, we simulate four distinct study cases characterized by varying load types and levels of distributed generation (DG), particularly solar PV, under both balanced and unbalanced conditions. Our findings highlight the critical role of DG in influencing voltage stability, revealing that deviations in voltage and current during grid imbalances remain within acceptable limits. The study underscores the importance of DG-based inverters in maintaining grid stability through reactive power support and sets the stage for future research on microgrid simulations and battery storage integration to further enhance system stability and performance.
Cyclic and Multi-Year Characterization of Surface Ozone at the WMO/GAW Coastal Station of Lamezia Terme (Calabria, Southern Italy): Implications for Local Environment, Cultural Heritage, and Human Health
Authors: D’Amico Francesco , Gullì Daniel , Lo Feudo Teresa , Ammoscato Ivano , Avolio Elenio , De Pino Mariafrancesca , Cristofanelli Paolo , Busetto Maurizio , Malacaria Luana , Parise Domenico , Sinopoli Salvatore , De Benedetto Giorgia , Calidonna Claudia Roberta
Published: October 2024

Unlike stratospheric ozone (O3), which is beneficial for Earth due to its capacity to screen the surface from solar ultraviolet radiation, tropospheric ozone poses a number of health and environmental issues. It has multiple effects that drive anthropogenic climate change, ranging from pure radiative forcing to a reduction of carbon sequestration potential in plants. In the central Mediterranean, which itself represents a hotspot for climate studies, multi-year data on surface ozone were analyzed at the Lamezia Terme (LMT) WMO/GAW coastal observation site, located in Calabria, Southern Italy. The site is characterized by a local wind circulation pattern that results in a clear differentiation between Western-seaside winds, which are normally depleted in pollutants and GHGs, and Northeastern-continental winds, which are enriched in these compounds. This study is the first detailed attempt at evaluating ozone concentrations at LMT and their correlations with meteorological parameters, providing new insights into the source of locally observed tropospheric ozone mole fractions. This research shows that surface ozone daily and seasonal patterns at LMT are “reversed” compared to the patterns observed by comparable studies applied to other parameters and compounds, thus confirming the general complexity of anthropogenic emissions into the atmosphere and their numerous effects on atmospheric chemistry. These observations could contribute to the monitoring and verification of new regulations and policies on environmental protection, cultural heritage preservation, and the mitigation of human health hazards in Calabria.
Optimization of Desalting Conditions for the Green Seaweed Codium fragile for Use as a Functional Food with Hypnotic Effects
Authors: Park Sohong , Kim Duhyeon , Kim Seonghui , Choi Gibeom , Yoo Hodeung , Park Serim , Cho Suengmok
Published: October 2024

Codium fragile (CF) contains various bioactive compounds, but its high salt content (39.8%) makes its use as a functional food challenging. Here, we aimed to optimize the desalination process and verify changes in functionality based on variations in salt and total phenolic contents. To optimize the CF immersion conditions for the lowest salt content and monitor the total phenolic content, a response surface methodology was used. The optimal immersion conditions were as follows: X1 (immersion temperature) = 42.8 °C; X2 (immersion time) = 1.0 h. An inverse correlation was noted between salt content and total phenolic content. Among the post-desalination processes, desalination with centrifugal dehydration (CD) significantly reduced salt content. CD ethanol extract (CD-E) induced the longest sleep duration in the pentobarbital-induced sleep test in ethanol extracts. Moreover, 1000 mg/kg CD-E had a significant effect on non-rapid eye movement sleep but did not affect delta activity. These findings highlight the potential of industrializing CF as a functional food through desalination and its promise as a natural aid for sleep promotion.
Phosphine Sorption on Paddy Rice: Effects on Fumigation and Grain Quality Parameters
Authors: Pereira Silvia Andréia Garibaldi , Cañizares Lázaro da Costa Corrêa , Meza Silvia Leticia Rivero , Ferreira Cristiano Dietrich , Jappe Silvia Naiane , Lang Gustavo Heinrich , Coradi Paulo Carteri , Oliveira Maurício de
Published: October 2024

During storage, infestation by insect pests occurs, causing quantitative and qualitative losses in grains, which requires the control of these insects with phosphine gas. Rice husk has a high phosphine adsorption capacity, influencing the gas concentration during fumigation and potentially leading to inefficient fumigation. Additionally, the high sorption of rice husk results in a higher residue of phosphine in the grain. Therefore, the objective of this study was to evaluate the phosphine sorption and phosphine residue in rice husk, paddy rice, and brown rice, as well as the industrial quality (head rice yield, rehydration capacity, cooking time, colorimetric profile) of brown and white rice during storage. To achieve this, fumigation of paddy rice, brown rice, and rice husks with 3.0 g·m−3 of phosphine was carried out for 240 h (recommended duration in the industry). A high sorption rate was observed in the rice husk (94.77%), paddy rice (97.61%), and, lastly, brown rice (35.17%). Due to the high sorption rate, only brown rice maintained a concentration above the recommended level for effective pest control (400 ppm for 120 h). Higher phosphine residues than permitted were observed in the rice husk (0.25 ppm). Lower rice head yields were observed in non-fumigated rice samples when analyzing the brown rice samples (66.21% for paddy rice and 65.01% for brown rice). A greater rehydration capacity was observed in fumigated samples at the beginning of storage when analyzing the brown rice samples (1.21 for paddy rice, 1.23 for brown rice), reducing the cooking time (24.00 for paddy rice, 23.80 for brown rice). More studies should be carried out to evaluate the effectiveness of fumigation on paddy rice, considering the high sorption rate of the paddy.
Technical Note: Rapid Species Barcoding Using Bento Lab Mobile Laboratory
Authors: Mahlerová Karolina , Vaňková Lenka , Tomsia Marcin , Vaněk Daniel
Published: October 2024

In scenarios when the morphological identification of samples is not feasible, the utilization of molecular analyses becomes an imperative. However, that can often be challenging in conditions where standard molecular laboratories cannot be established. In this study, we present a simplified and field-friendly protocol of the previously published Triplex PCR Assay for the identification of mammalian and plant sample origin using a fully portable molecular laboratory from Bento Lab (Bento Bioworks Ltd., London, UK), effectively eliminating the need for a traditional laboratory setup. The protocol in combination with correctly selected kits enables DNA extraction, result evaluation based on electrophoresis, and direct use of the PCR products for downstream analyses such as Sanger sequencing and third-generation sequencing; therefore, enabling the use of molecular analysis directly in situ or for educational purposes in a classroom.
Analyzing the Impact of COVID-19 on Travel and Search Distances for Prominent Landmarks: Insights from Google Trends, X, and Tripadvisor
Authors: Cao Jiping , Hochmair Hartwig H. , Kirilenko Andrei , Owuor Innocensia
Published: October 2024

The COVID-19 pandemic profoundly affected people’s travel behavior and travel desires, particularly regarding trips to prominent destinations. This study explores the pandemic’s impact on travel behavior and online search patterns for 12 landmarks across six continents, utilizing data from three online platforms, i.e., Google Trends, X, and Tripadvisor. By comparing visitation and search behavior before (2019) and during (2020/2021) the pandemic, the study uncovers varying effects on the spatial separation between user location and landmarks. Google Trends data indicated a decline in online searches for nearby landmarks during the pandemic, while data from X showed an increased interest in more distant sites. Conversely, Tripadvisor reviews reflected a decrease in the distance between users’ typical review areas and visited landmarks, underscoring the effects of international travel restrictions on long distance travel. Although the primary focus of this study concerns the years most affected by COVID-19, it will also analyze Tripadvisor data from 2022 to provide valuable insights into the travel recovery beyond the pandemic.
Bloodletting for Acute Stroke Recovery: A Systematic Review and Meta-Analysis
Authors: Kim Mikyung , Han Changho
Published: October 2024

Background: Bloodletting is a non-pharmacological treatment commonly used for acute stroke in traditional East Asian medicine. This study evaluated the efficacy and safety of bloodletting in acute stroke recovery. Methods: We conducted a comprehensive search of eight electronic databases up to 4 June 2024 to identify relevant randomized controlled trials (RCTs). Review Manager 5.4 was used for the meta-analysis, with methodological quality assessed using the Cochrane Risk of Bias 2 tool and the GRADE approach. Results: Seventeen RCTs were included in this meta-analysis. The bloodletting group showed statistically significant improvements in neurological deficits compared to the non-bloodletting group, as measured using the National Institutes of Health Stroke Scale (mean difference [MD]: −2.08, 95% confidence interval [CI]: −3.13 to −1.02) and the treatment effective rate (risk ratio: 1.17, 95% CI: 1.11 to 1.22). Motor function also improved significantly in both upper (Fugl-Meyer Assessment, MD: 12.20, 95% CI: 9.67 to 14.73) and lower extremities (MD: 3.86, 95% CI: 2.16 to 5.56). The effect on daily living activities was not significant overall, but benefits were observed in patients treated within three days of stroke onset (Barthel Index, standardized MD: 0.85, 95% CI: 0.01 to 1.69). No significant differences in the frequency of adverse events were observed between the groups. Conclusion: Bloodletting may be an effective and safe adjunctive therapy for patients with acute stroke receiving conventional Western medical treatment. However, further research is necessary because of the small sample sizes and low quality of the included studies.
Work Disparities and the Health of Nurses in Long-Term Care: A Scoping Review
Authors: Shaw Lynn , Masood Mehvish , Neufeld Kimberly , Connelly Denise , Stanley Meagan , Guitar Nicole A. , Garnett Anna , Nikkhou Anahita
Published: October 2024

Work disparities, such as unfairness in pay or unequal distribution of work experienced by nurses in long-term care (LTC), can impact the retention and health of this workforce. Background: Despite the significant impact of disparities on nurses’ health in LTC, a literature review on work disparities of nurses in LTC has not been conducted. Method: This scoping review aimed to explore the nature and extent of research on meso-level work disparities experienced by nurses in LTC and its links with nurse health and well-being. Five databases were searched: MEDLINE (Ovid), EMBASE (Ovid), PsycINFO (Ovid), SCOPUS, and CINAHL (EBSCO host). Results: Of the 5652 articles retrieved, 16 studies (14 quantitative and 2 qualitative) published between 1997 and 2024 met the inclusion criteria. A total of 53 work disparities were identified. Only four articles investigated the association of a work disparity with a variable of health (e.g., physical, mental, or poor general health). Conclusions: The results suggest that more attention to how disparities impact nurses’ health and lived experiences is warranted. Meso-level disparities from this review provide an initial basis to consider possibilities in the workplace, especially in supporting equity and opportunities for health and well-being at work (e.g., through fair access to professional growth opportunities and a more equitable balance of work expectations and demands of nursing staff). Future studies of the intersection of macro- and meso-level factors are needed to inform better workplace practices and social and economic policies to support the well-being, health, and safety of nurses at work in LTC.
Descriptive Representation and Reproductive Health Outcomes: The Role of Women Candidates in Reducing Teen Birth Rates
Authors: Cortina Jeronimo , Hardin Shana
Published: October 2024

Background/Objectives: Teen birth rates remain a pressing public health issue in the United States, with significant long-term health risks for both mothers and children. Previous research has primarily focused on the impact of women in elected office on reproductive health outcomes, but less is known about the influence of women candidates. This study explores the relationship between the number of women candidates in county-level elections and county-level teen birth rates, highlighting the role of women candidates as visible role models and agents of potential policy change. Methods: We utilized a dataset covering county-level elections from 2010 to 2020, along with teen birth rate data from the CDC. We employed a multilevel model to analyze the relationship between the cumulative number of women candidates and teen birth rates, controlling for socioeconomic and health-related factors, such as insurance coverage and social vulnerability. Results: The findings indicate that as the number of women candidates increased, the estimated county-level teen birth rate declined. This effect was observed across different election years, with more substantial impacts in midterm and presidential elections. The analysis also confirmed that socioeconomic conditions, such as a lack of health insurance, contribute to higher teen birth rates. Conclusions: Women candidates, even when not elected, serve as important role models and influence reproductive health outcomes in their communities. Increasing the number of women candidates at the local level may be an effective strategy for reducing teen birth rates and improving public health outcomes.
Risk Factors Associated with Unplanned Hospitalization Among Long-Term Care Facility Residents: A Retrospective Study in Central Taiwan
Authors: Lee Chiu-Hsiang , Chen Yu-An , Yang Chiu-Ming , Huang Kuang-Hua , Tsai Tung-Han , Chang Yuanmay , Shieh Shwn-Huey
Published: October 2024

Most residents of long-term care facilities (LTCFs) are patients with chronic diseases requiring long-term care. Unplanned hospitalization of older and frailer residents from LTCFs reduces their mobility and increases the number of infections, complications, and falls that might lead to severe disability or death. This study aimed to identify the critical risk factors associated with unplanned hospitalization among LTCF residents in Taiwan, providing insights that could inform better care practices in similar settings globally. A retrospective study was conducted using inpatient data from a medical center in central Taiwan, covering the period from 2011 to 2019. A total of 1220 LTCF residents were matched with general patients using propensity score matching. Multiple logistic regression analyses were performed to identify factors associated with unplanned hospitalization, controlling for relevant variables. LTCF residents had a significantly higher risk of unplanned hospitalization compared to general patients (OR = 1.44, 95% CI = 1.21–1.73). Key risk factors included advanced age (≥85 years, OR = 1.25, 95% CI = 1.02–1.54), the presence of comorbidities such as diabetes (OR = 1.17, 95% CI = 1.03–1.33) and renal failure (OR = 1.63, 95% CI = 1.42–1.86), high fall risk (OR = 2.67, 95% CI = 2.30–3.10), and being bedridden (OR = 6.55, 95% CI = 5.48–7.85). The presence of a tracheostomy tube also significantly increased hospitalization risk (OR = 1.73, 95% CI = 1.15–2.59). LTCF residents are at a higher risk of unplanned hospitalization, particularly those with specific comorbidities, physical limitations, and indwelling medical devices. These findings underscore the need for targeted interventions to manage these risks, potentially improving care outcomes for LTCF residents globally.
The Current Status of OCT and OCTA Imaging for the Diagnosis of Long COVID
Authors: Jerratsch Helen , Beuse Ansgar , Spitzer Martin S. , Grohmann Carsten
Published: October 2024

(1) With persistent symptoms emerging as a possible global consequence of COVID-19, the need to understand, diagnose, and treat them is paramount. This systematic review aims to explore the potential of optical coherence tomography (OCT) and/or optical coherence tomography angiography (OCTA) in effectively diagnosing long COVID. (2) The database PubMed and, to reduce selection bias, the AI research assistant Elicit, were used to find relevant publications in the period between February 2021 and March 2024. Included publications on OCT and OCTA analysis of participants with acute COVID symptoms, those after recovery, and participants with long COVID symptoms were organized in a table. Studies with participants under the age of 18, case reports, and unrelated studies, such as pure slit-lamp examinations and subgroup analyses were excluded. (3) A total of 25 studies involving 1243 participants and 960 controls were reviewed, revealing several changes in the posterior eye. Long COVID participants displayed significant thinning in retinal layers in the OCT, including the macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL), and inner plexiform layer (IPL). Divergent findings in recovered cohorts featured mRNFL reduction, GCL increase and decrease, and GCL-IPL decrease. Long COVID OCTA results revealed reduced vessel density (VD) in the superficial capillary plexus (SCP), intermediate capillary plexus (ICP), and deep capillary plexus (DCP). In recovered patients, SCP consistently showed a reduction, and DCP exhibited a decrease in five out of six publications. The foveal avascular zone (FAZ) was enlarged in five out of nine publications in recovered participants. (4) During various stages of COVID-19, retinal changes were observed, but a comparison between long COVID and recovered cohorts was aggravated by diverse inclusion and exclusion criteria as well as small sample sizes. Changes in long COVID were seen in most OCT examinations as thinning or partial thinning of certain retinal layers, while in OCTA a consistently reduced vessel density was revealed. The results suggest retinal alterations after COVID that are variable in OCT and more reliably visible in OCTA. Further research with larger samples is important for advancing long COVID diagnosis and management.
Numerical Analysis of the Influence of Runoff Input on Salinity Distribution and Its Mechanisms in Laizhou Bay
Authors: Ju Kaixuan , Xiong Lehang , Liu Tao , Li Zilong , Zhang Minxia
Published: October 2024

This study employs the MIKE 3 Flow Model, incorporating forcing conditions such as inflow from 18 major rivers along the Bohai coast, wind, precipitation, evaporation, and solar radiation, to develop a hydrodynamic and temperature-salinity model for the Bohai Sea, using a finer mesh for more detailed simulation in Laizhou Bay. The residual current in the surface layer primarily flowed eastward, exhibiting coastal transport characteristics in the southern region, leading to the formation of a large low-salinity region. The bottom salinity distribution closely mirrored that of the surface, with the isohaline shifting shoreward due to the high-salinity Bohai Sea water transported by the residual current. By grouping major runoff sources according to river outlet locations and residual current patterns, the study analyzed the impact of freshwater plumes formed by runoff from different directions on the salinity distribution in Laizhou Bay. The results indicate that the influence of freshwater inputs on both the mean salinity and the area of low-salinity zones in Laizhou Bay, ranked from greatest to least, is as follows: the Yellow River, the southwest, and the southeast. The variation in the area of low-salinity regions is closely related to factors such as runoff volume, residual currents, and the selection of boundaries for the low-salinity regions.
Scheduling of Mixed Fleet Passing Through River Bottleneck in Multiple Ways
Authors: Li De-Chang , Yang Hua-Long
Published: October 2024

This paper addresses the scheduling problem of a mixed fleet passing through a river bottleneck in multiple ways, considering the impact of streamflow velocity, the fuel cost with different sailing speeds, and the potential opportunity cost of various types and sizes of vessels. From the perspective of centralized management by river bottleneck authorities, a unified scheduling approach is proposed, and a nonlinear model is constructed, where the total fuel cost and potential opportunity cost of the fleet are minimized. To handle the nonlinear terms in the model, an outer approximation technique is applied to linearize the model while ensuring the approximation error remains controlled. The optimal value range of the nonlinear variables is also proven to ensure solution speed. Furthermore, the applicability and effectiveness of the model and solution method are validated through a real-world case study on the Yangtze River. The results show the following: (1) Unified collaborative scheduling by bottleneck authorities can ensure the optimal total cost of the fleet is effectively met and that the vessels passing through the river bottleneck are arranged under rational ways. (2) When fuel consumption is the same as that of traditional oil-fuelled vessels, giving priority to liquefied natural gas (LNG)-fuelled vessels to pass through the river bottleneck can reduce the potential opportunity cost and the total cost of the fleet reasonably. (3) In accordance with changes in the fuel price, streamflow velocity, and proportion of LNG-fuelled vessels, timely adjusting the opportunity cost expectations, vessel arrival time, and service times of bottleneck passing ways is crucial for shipowners and authorities to reduce fleet waiting times at the bottleneck, delay time, and the total cost.
Effect of CO2 Thickeners on CH4-CO2 Replacement in Hydrate-Bearing Sediment
Authors: Zhou Xuebing , Zhou Jiahong , Long Zhen , Wen Huiyun , Fan Shuanshi , Liang Deqing
Published: October 2024

CO2 fracturing is known as the best solution to improve the efficiency of the CO2 replacement of natural gas hydrates, but the effect of CO2 thickeners on CH4-CO2 replacement are barely noticed. In this work, the effect of four kinds of CO2 thickener—including DL-Lactic acid, polyvinyl acetate, ethyl trifluoroacetate and octamethyl trisiloxane—on the CH4-CO2 replacement in quartz sand was measured thermodynamically and kinetically. The results show that the majority of the CO2 thickeners had no effect on the equilibria of the CH4 and CO2 hydrates, except for DL-Lactic acid, where the temperature depression caused by the addition of 5.5 wt% DL-Lactic acid was about 0.52 and 0.48 K for the CH4 and CO2 hydrates, respectively. In the kinetic measurements, the CH4-CO2 replacement was promoted via the addition of the CO2 thickeners, except DL-Lactic acid. The CO2 thickeners were suggested to strengthen the CH4-CO2 replacement by enhancing the gas exchange in the pore space. Octamethyl trisiloxane, which could promote CH4 recovery and CO2 capture at a low concentration, was suggested to be an ideal CO2 thickener for CH4-CO2 replacement.
A Novel Bile Duct-Saving Portal Ligation Technique for Subtotal Hepatectomy Survival Operations in Rats
Authors: Savsani Kush , Alfonso Anjelica , Jo Ester , Park Andrew , Lee Seung Duk
Published: October 2024

Background: Creating a model for acute liver failure in animal models is essential for research on liver regeneration and cancer. Current surgical techniques allow for a maximum of 80% partial hepatectomy in rats, with low survival rates due to poor inflow control. The common resection technique involves ligation at the liver lobe neck, causing peri-operative blood loss and postoperative blood loss. Methods: A 90% partial hepatectomy was performed on 5 rats using a bile duct-saving portal ligation technique, involving two hilum dissections for bile duct preservation. The first dissection controlled the blood supply to the median and left lateral lobes, and the second to the right inferior and superior lobes. Before closing, all rats were given 5 mL of 10% dextrose intraperitoneally and had access to ClearH2O DietGel Recovery and 20% dextrose. Weight and behavior were closely monitored for seven days post-operatively. Results: This method resulted in 100% survival, with a 3.1% increase in liver mass and 12.3% increase in liver-to-body mass ratio. Conclusions: This technique is the first bile duct-saving portal ligation for rodent models of acute liver failure, with long-term survival and complete hepatic regeneration. Our procedure offers a viable 90% hepatectomy model for research with improved survival and regeneration outcomes.
Multiexposed Image-Fusion Strategy Using Mutual Image Translation Learning with Multiscale Surround Switching Maps
Authors: Go Young-Ho , Lee Seung-Hwan , Lee Sung-Hak
Published: October 2024

The dynamic range of an image represents the difference between its darkest and brightest areas, a crucial concept in digital image processing and computer vision. Despite display technology advancements, replicating the broad dynamic range of the human visual system remains challenging, necessitating high dynamic range (HDR) synthesis, combining multiple low dynamic range images captured at contrasting exposure levels to generate a single HDR image that integrates the optimal exposure regions. Recent deep learning advancements have introduced innovative approaches to HDR generation, with the cycle-consistent generative adversarial network (CycleGAN) gaining attention due to its robustness against domain shifts and ability to preserve content style while enhancing image quality. However, traditional CycleGAN methods often rely on unpaired datasets, limiting their capacity for detail preservation. This study proposes an improved model by incorporating a switching map (SMap) as an additional channel in the CycleGAN generator using paired datasets. The SMap focuses on essential regions, guiding weighted learning to minimize the loss of detail during synthesis. Using translated images to estimate the middle exposure integrates these images into HDR synthesis, reducing unnatural transitions and halo artifacts that could occur at boundaries between various exposures. The multilayered application of the retinex algorithm captures exposure variations, achieving natural and detailed tone mapping. The proposed mutual image translation module extends CycleGAN, demonstrating superior performance in multiexposure fusion and image translation, significantly enhancing HDR image quality. The image quality evaluation indices used are CPBDM, JNBM, LPC-SI, S3, JPEG_2000, and SSEQ, and the proposed model exhibits superior performance compared to existing methods, recording average scores of 0.6196, 15.4142, 0.9642, 0.2838, 80.239, and 25.054, respectively. Therefore, based on qualitative and quantitative results, this study demonstrates the superiority of the proposed model.
Application of Kirchhoff Migration from Two-Dimensional Fresnel Dataset by Converting Unavailable Data into a Constant
Authors: Park Won-Kwang
Published: October 2024

In this contribution, we consider an application of the Kirchhoff migration (KM) technique for fast and accurate identification of small dielectric objects from two-dimensional Fresnel experimental dataset. Generally, for successful application of the KM, a complete set of elements from the so-called multi-static response (MSR) matrix must be collected; however, in the Fresnel experimental dataset, many of the elements of an MSR matrix are not measurable. Nevertheless, the existence, location, and outline shape of small objects can be retrieved using the KM by converting unavailable data into the zero constant. However, the theoretical reason behind such conversion has not been confirmed to date. In order to explain this theoretical reason, we convert unavailable measurement data into a constant and demonstrate that the imaging function of the KM can be expressed by an infinite series of the Bessel functions of integer order of the first kind, the object’s material properties, and the converted constant. Following the theoretical result, we confirm that converting unknown data into the zero constant guarantees good results and unique determination of the objects. Finally, various numerical simulation results from Fresnel experimental dataset are presented and discussed to validate the theoretical result.
Relational Strict Almost Contractions Employing Test Functions and an Application to Nonlinear Integral Equations
Authors: Filali Doaa , Khan Faizan Ahmad
Published: October 2024

The present study deals with some fixed-point outcomes under a nonlinear formulation of strict almost contractions in a metric space endued with an arbitrary relation. The outcomes established herein enhance and develop various existing outcomes. To convince you of the infallibility of our outcomes, a few examples are presented. We apply our findings to investigate the validity of the unique solution of a nonlinear integral problem.
Impact of Forage Sources on Ruminal Bacteriome and Carcass Traits in Hanwoo Steers During the Late Fattening Stages
Authors: Kang Ryukseok , Song Jaeyong , Park Joong Kook , Yun Sukjun , Lee Jeong Heon , Ahn Jun Sang , Yu Chaemin , Kim Geonwoo , Jeong Jongsik , Oh Myeong-Gwan , Jo Wanho , Lee Woohyung , Tilahun Mekonnen , Park Tansol
Published: October 2024

This study examined the effects of different forage sources on the ruminal bacteriome, growth performance, and carcass characteristics of Hanwoo steers during the fattening stage. In Korea, where high-concentrate feeding is common, selecting suitable forage is crucial for sustainable beef production. Fifteen 23-month-old Hanwoo steers, weighing an average of 679.27 ± 43.60 kg, were fed the following five different forage sources: oat hay (OAT), rye silage (RYE), Italian ryegrass (IRS), barley forage (BAR), and rice straw silage (RSS), alongside 1.5 kg of dry matter concentrate daily for five months. Carcass traits were evaluated post-slaughter, and rumen fluid samples were analyzed using full-length 16S rRNA gene sequencing to determine the bacteriome composition. The forage source significantly affected the alpha-diversity indices and bacteriome biomarkers linked to the feed efficiency and ruminal fermentation. Differences in the backfat thickness and meat yield index were noted, with alpha-diversity indices correlating with carcass traits. The phylum Planctomycetota, especially the family Thermoguttaceae, was linked to nitrogen fixation in high-protein diets like IRS, while the genus Limimorpha emerged as a biomarker for the meat yield. These findings highlight the importance of forage selection during late fattening to optimize beef production, considering diet and bacteriome shifts.
FLAC3D Simulation of Caving Mechanism and Strata Fracture Response in Underground Mining
Authors: Saadat Mahdi , Khishvand Mattin , Seccombe Andrew
Published: October 2024

This paper presents an innovative numerical approach to simulating the progressive caving of rock mass in the overburden and floor during longwall mining. A modified caving algorithm is incorporated into FLAC3D 9.0, augmented with the IMASS constitutive model, to accurately replicate the fracturing response of various strata. This study aimed to analyze the longwall caving performance, overburden fracturing response, and shield support characteristics to optimize the mining process and enhance safety. The numerical analysis revealed a progressive stress release at the longwall face, attributed to damage in the form of spalling, which was accompanied by a high level of displacement. The fracture process zone above the shield canopy was not significant, indicating the effective performance of the shield in controlling the roof. However, the floor heave highlights the need for the implementation of effective risk and safety measures. Goaf is predicted to form with a longwall advance rate of 25.0–30.0 m, resulting from progressive macroscopic fracturing caused by the development of cracks initiated by bedding plane and rock mass failures. Above the caved zone, an active fracture zone is observed to evolve due to the continuous longwall mining and caving process.
Rational Design of High-Performance Photocontrolled Molecular Switches Based on Chiroptical Dimethylcethrene: A Theoretical Study
Authors: Han Li , Wang Mei , Zhang Yifan , Cui Bin , Liu Desheng
Published: October 2024

The reversible photo-induced conformation transition of a single molecule with a [5]helicene backbone has garnered considerable interest in recent studies. Based on such a switching process, one can build molecular photo-driven switches for potential applications of nanoelectronics. But the achievement of high-performance reversible single-molecule photoswitches is still rare. Here, we theoretically propose a 13,14-dimethylcethrene switch whose photoisomerization between the ring-closed and ring-open forms can be triggered by ultraviolet (UV) and visible light irradiation. The electronic structure transitions and charge transport characteristics, concurrent with the photo-driven electrocyclization of the molecule, are calculated by the non-equilibrium Green’s function (NEGF) in combination with density functional theory (DFT). The electrical conductivity bears great diversity between the closed and open configurations, certifying the switching behavior and leading to a maximum on–off ratio of up to 103, which is considerable in organic junctions. Further analysis confirms the evident switching behaviors affected by the molecule–electrode interfaces in molecular junctions. Our findings are helpful for the rational design of organic photoswitches at the single-molecule level based on cethrene and analogous organic molecules.
Recent Advances in Antifreeze Peptide Preparation: A Review
Authors: Xia Bo , Wang Juntao , Chen Honghao , Lin Shuyan , Pan Buchun , Wang Nan
Published: October 2024

Antifreeze agents play a critical role in various fields including tissue engineering, gene therapy, therapeutic protein production, and transplantation. Commonly used antifreeze agents such as DMSO and other organic substances are known to have cytotoxic effects. Antifreeze proteins sourced from cold-adapted organisms offer a promising solution by inhibiting ice crystal formation; however, their effectiveness is hindered by a dynamic ice-shaping (DIS) effect and thermal hysteresis (TH) properties. In response to these limitations, antifreeze peptides (AFPs) have been developed as alternatives to antifreeze proteins, providing similar antifreeze properties without the associated drawbacks. This review explores the methods for acquiring AFPs, with a particular emphasis on chemical synthesis. It aims to offer valuable insights and practical implications to drive the realm of sub-zero storage.
The Emerging Applications of Raman Spectroscopy in Clinical Oncology: A Narrative Review Focused on Circulating Tumor DNA Detection and Therapeutic Drug Monitoring
Authors: Narayanan Sathya , Wang Yuling , Gurney Howard
Published: October 2024

Raman spectroscopy is a technique which involves quantitative and qualitative molecular analysis based on the interaction between incident light and isolation of scattered wavelengths in generating a molecular fingerprint. It has a broad array of potential scientific applications, encompassing areas as diverse as food science and forensics. However, it may also be highly useful in clinical oncology. A recent focus of research in oncology has been in achieving the individualisation of care. Two important strategies to achieve a so-called “precision oncology” approach may include the detection of circulating tumour DNA (ctDNA) in more objectively evaluating treatment response and guiding de-escalation and intensification approaches in systemic therapy and therapeutic drug monitoring (TDM). Therapeutic drug monitoring involves the quantitation of plasma drug levels in order to tailor medication dosing in optimizing outcomes. The existing approaches to characterize small molecules, such as fluorescence-based and chromatographic strategies, may be limited by high costs, long turnaround times, and bulky equipment. Surface-enhanced Raman spectroscopy (SERS) may be deployed by utilizing a handheld device, with the potential for point of care, rapid turnaround, low-cost assessment of clinically relevant parameters, and prompt implementation of attendant changes in treatment. Although there is a growing body of data supporting the implementation of TDM and evaluation of ctDNA in achieving precision medicine, the uptake of such approaches remains relatively limited outside of clinical trials. As stated, the nature of existing analytical methodologies may prove to be a significant barrier to the routine clinic-based implementation of such approaches. Therefore, we provide the existing evidence for SERS in alleviating these barriers. We also provide insights into how SERS could contribute to clinical oncology.
Exploring Metarhabditis blumi as a Model for Anthelmintic Drug Discovery
Authors: Delmondes Aline Ferreira Santos , Castello-Branco Santos Ander , Genuncio Julia Rodrigues , Da-Silva Silvia A. G. , Lopes-Torres Eduardo José
Published: October 2024

Helminth infections pose a significant global health challenge, as existing drugs often lack efficacy and may be contraindicated in some populations. Progress in the development of new drugs is hindered by the lack of innovative models for use in drug research. Metarhabditis blumi nematodes, which are associated with parasitic otitis in cattle, can severely affect the nervous system, leading to death. The treatment and control of this pathology face similar limitations to those for other parasitic diseases. Our study aimed to standardize M. blumi as a model for evaluating the anthelmintic activity of new drugs. Larvae (L3) and adult worms were treated with the reference drugs albendazole (16 µM) and ivermectin (2.5 µM) diluted in an NGM medium for 24 h, and various parameters were evaluated. Motility and mobility were analyzed using a video tracking and analysis program. Morphological and ultrastructural characterizations were performed after chemical fixation using light and scanning electron microscopy (SEM). The results showed that ivermectin was more effective than albendazole in treating M. blumi adults and L3. The SEM images revealed drug-induced ultrastructural changes. Compared to previous studies using the established Caenorhabditis elegans model, M. blumi demonstrated greater resistance to both albendazole and ivermectin. We conclude that M. blumi is a viable model for drug discovery assays and a valuable new experimental model for various biological studies, highlighting that, unlike C. elegans, M. blumi is associated with parasitism.
Flavonoid-Mediated Suppression of Tumor Angiogenesis: Roles of Ang-Tie/PI3K/AKT
Authors: Saini Shallu , Tuli Hardeep Singh , Saini Reena V. , Saini Adesh K. , Sak Katrin , Kaur Damandeep , Shahwan Moyad , Chauhan Ritu , Chauhan Abhishek
Published: October 2024

Angiogenesis is a process involved in the formation of new blood capillaries from pre-existing ones. It is regulated by several anti-angiogenic molecules involved in tumor growth and metastasis. The endothelial angiopoietin Ang-Tie/PI3K/AKT growth receptor pathway is necessary for healthy vascular development. The activation of AKT is controlled by a multistep process involving phosphoinositide 3-kinase (PI3K). This article aims to provide an overview of the role and mechanism of the Ang-Tie/PI3K/AKT signaling pathways and the potential of flavonoids as anti-angiogenic drugs. Flavonoids have shown great potential in preventing angiogenesis by targeting signaling pathways and exhibit additional anti-cancer properties. Research studies have revealed that the currently available anti-angiogenic drugs do not meet the safety and efficacy standards for treating tumor growth. Phytocompounds have long been a valuable resource for the development of novel therapeutic drugs. This article explores recent findings explaining the role and mechanism of the Ang-Tie/PI3K/AKT signaling pathways, as well as the interaction of flavonoids with angiogenic signaling pathways as a novel therapeutic approach. Several investigations have shown that synergistic studies of natural phytocompounds have great potential to target these pathways to inhibit tumor growth. Therefore, flavonoid-based medications may offer a more effective synergistic strategy to treat cancer.
Modeling a Fully Polarized Optical Fiber Suitable for Photonic Integrated Circuits or Sensors
Authors: Sun Wenbo
Published: October 2024

A method is developed to make an optical fiber that only transmits fully linearly polarized light and maintains the polarization state. The method for efficient ingesting laser into this fiber is also reported. Using an optical fiber with a prism head, we can compress a plane wave into the thin rectangular cross-section fiber, and the light intensity within the fiber is much larger than that of the incidence wave. Our finite-difference time-domain (FDTD) simulation results show that the compressed light in the fiber becomes fully polarized and maintains the polarization state, and can be well coupled out by the resonance rings. This method is suitable for developing highly efficient polarization-maintaining optical fibers in a much simpler way, for applications in photonic integrated circuits or optical sensors.
Interference Generation of a Reverse Energy Flow with Varying Orbital and Spin Angular Momentum Density
Authors: Ustinov Andrey V. , Porfirev Alexey P. , Khonina Svetlana N.
Published: October 2024

This paper presents a novel method for generating and shaping reverse energy flow through the interference of light fields from a minimal number of point light sources. Until now, reverse energy flow has only been observed using complex light fields, such as optical vortices or cylindrical vector beams, limiting the formation of reverse energy flow near the optical axis. We demonstrate both analytically and numerically that unbounded regions of reverse energy flow can be achieved with just two point light sources, positioned asymmetrically at specific angles (e.g., 90 or 45 degrees) and with particular polarization states. The results indicate that the relative reverse energy flow can be enhanced by increasing the number of sources to three or four, adjusting their polarization, or introducing a vortex phase singularity. The presence of an initially embedded asymmetry in the fields under consideration leads to the formation of a non-uniform distribution of spin and orbital angular momentum density. Variations in the polarization state, as well as the introduction of a vortex phase singularity, allow for changing the distribution of angular momentum density while maintaining the presence of a reverse energy flow. We also explore the feasibility of implementing the obtained results using sectional phase diffractive optical elements, which will enhance the energy efficiency of the generated fields compared to point sources.