bluuebunny/crossref_metadata_2025 huggingface dataset:
Nanoscale organization of CaV2.1 splice isoforms at presynaptic terminals: implications for synaptic vesicle release and synaptic facilitation
Authors: Cingolani Lorenzo A. , Thalhammer Agnes , Jaudon Fanny , Muià Jessica , Baj Gabriele
Published: September 2023

The distance between CaV2.1 voltage-gated Ca2+ channels and the Ca2+ sensor responsible for vesicle release at presynaptic terminals is critical for determining synaptic strength. Yet, the molecular mechanisms responsible for a loose coupling configuration of CaV2.1 in certain synapses or developmental periods and a tight one in others remain unknown. Here, we examine the nanoscale organization of two CaV2.1 splice isoforms (CaV2.1[EFa] and CaV2.1[EFb]) at presynaptic terminals by superresolution structured illumination microscopy. We find that CaV2.1[EFa] is more tightly co-localized with presynaptic markers than CaV2.1[EFb], suggesting that alternative splicing plays a crucial role in the synaptic organization of CaV2.1 channels.
Dynamic mode decomposition and bivariate autoregressive short-term prediction of Earth rotation parameters
Authors: Ligas Marcin , Michalczak Maciej
Published: September 2023

In this contribution two new approaches are applied to predict polar motion and length-of-day. The first one is based on Dynamic Mode Decomposition (DMD), that is purely data-driven and is capable of reconstructing and forecasting time series in one numerical procedure. The other one is based on a vector autoregression of order p – VAR(p), which is a vector counterpart of AR(p) that accounts for an evolution of variables in time and a coevolution with other variables. DMD was applied to polar motion and length-of-day whilst VAR(p) to a joint prediction of polar motion. A prediction experiment concerned 30-day forecast horizon with a 7-day shift. It was performed separately for years 2017–2022 giving 48 predictions within each year. This study uses IERS EOP 14 C04 (IAU2000) as a reference for all computations and a mean absolute prediction error (MAPE) as a measure of prediction quality. For DMD, MAPEs for x coordinate of the pole vary from 0.22–0.30 mas for the 1st day and 6.64–8.56 mas for the 30th day of prediction depending on the year whilst those values vary from 0.20–0.27 mas and 5.27–7.66 mas for VAR(p) based prediction. Corresponding values for y coordinate of the pole vary from 0.15–0.23 mas and 4.27–5.93 mas for DMD, whilst 0.13–0.21 mas and 3.46–3.82 mas for VAR(p). In case of LOD forecast, MAPEs vary from 0.023–0.031 ms for the 1st day and 0.142–0.205 ms for the 30th day depending on the year.
Acoustic correlates of Burmese voiced and voiceless sonorants
Authors: Repetti-Ludlow Chiara
Published: September 2023

Voiceless sonorant consonants are typologically rare segments, appearing in only a few of the world’s languages, including Burmese. In this study, Burmese sonorants and their adjacent vowels are investigated in an attempt to (1) determine what acoustic correlates distinguish voiced and voiceless sonorants and (2) determine whether there are multiple realizations of voiceless sonorants and, if so, establish what acoustic correlates distinguish them. In order to pursue these questions, a production study was carried out and target words were analyzed, demonstrating that Burmese voiceless sonorants have a spread glottis period resulting in turbulent airflow 78 % of the time. Findings from linear mixed-effects models showed that voiced and voiceless sonorants are significantly different in terms of duration of the sonorant, F0 of the sonorant, and strength of excitation measured over the following vowel. A linear discriminant analysis was able to predict voicing category with 86.7 % accuracy, with the duration of the spread glottis period being the best indicator of voicelessness, followed by the cues that were significant in the linear mixed-effects models. In cases when the spread glottis period is absent from voiceless sonorants, the sonorant only has correlates that are associated with voicelessness (such as F0 and strength of excitation) but not correlates that are associated with the spread glottis gesture (such as duration and harmonics-to-noise ratio). These results have implications both for our understanding of the acoustics of Burmese sonorants and for our understanding of voiceless sonorants more generally.
Blood Purification and the Temple in Revelation
Authors: Sanchez Christian P.
Published: September 2023

This article argues that many of Revelation’s ancient Jewish, Greek, and Roman audience members would have recognized a cosmic blood purification ritual at work in chapters 15–16. I contend first that many early audiences would have perceived the cosmos in Revelation as an operational temple (at least in Rev 4–16). I, then, expose similarities between the bowls of wrath and ancient blood purification rituals for sacred space. In the final section of this article, I demonstrate how many ancient audiences would have understood global pollution to be a major problem for Revelation’s narrative and how the blood purification-like ritual of Rev 15–16 resolves it.
Human Brain Project Partnering Projects Meeting: Status Quo and Outlook
Authors: Lorents Angeliki , Colin Marie-Elisabeth , Bjerke Ingvild Elise , Nougaret Simon , Montelisciani Luca , Diaz Marissa , Verschure Paul , Vezoli Julien
Published: September 2023

As the European Flagship Human Brain Project (HBP) ends in September 2023, a meeting dedicated to the Partnering Projects (PPs), a collective of independent research groups that partnered with the HBP, was held on September 4–7, 2022. The purpose of this meeting was to allow these groups to present their results, reflect on their collaboration with the HBP and discuss future interactions with the European Research Infrastructure (RI) EBRAINS that has emerged from the HBP. In this report, we share the tour-de-force that the Partnering Projects that were present in the meeting have made in furthering knowledge concerning various aspects of Brain Research with the HBP. We describe briefly major achievements of the HBP Partnering Projects in terms of a systems-level understanding of the functional architecture of the brain and its possible emulation in artificial systems. We then recapitulate open discussions with EBRAINS representatives about the evolution of EBRAINS as a sustainable Research Infrastructure for the Partnering Projects after the HBP, and also for the wider scientific community.
Energy Expenditure Homeostasis Requires ErbB4, an Obesity Risk Gene, in the Paraventricular Nucleus
Authors: Santiago-Marrero Ivan , Liu Fang , Wang Hongsheng , Arzola Emily P. , Xiong Wen-Cheng , Mei Lin
Published: September 2023

Obesity affects more than a third adult population in the United States; the prevalence is even higher in patients with major depression disorders. GWAS studies identify the receptor tyrosine kinase ErbB4 as a risk gene for obesity and for major depression disorders. We found that ErbB4 was enriched in the paraventricular nucleus of the hypothalamus (PVH). To investigate its role in metabolism, we deleted ErbB4 by injecting a Cre-expressing virus into the PVH of ErbB4-floxed male mice and found that PVH ErbB4 deletion increased weight gain without altering food intake. ErbB4 PVH deletion also reduced nighttime activity and decreased intrascapular brown adipose tissue (iBAT) thermogenesis. Analysis of covariance (ANCOVA) revealed that ErbB4 PVH deletion reduced O2consumption, CO2production and heat generation in a manner independent of body weight. Immunostaining experiments show that ErbB4+ neurons in the PVH were positive for oxytocin (OXT); ErbB4 PVH deletion reduces serum levels of OXT. We characterized mice where ErbB4 was specifically mutated in OXT+ neurons and found reduction in energy expenditure, phenotypes similar to PVH ErbB4 deletion. Taken together, our data indicate that ErbB4 in the PVH regulates metabolism likely through regulation of OXT expressing neurons, reveal a novel function of ErbB4 and provide insight into pathophysiological mechanisms of depression-associated obesity.
“It’s a Calling. You Answered.”
Authors: Wong Casey Philip , Esposito Jennifer
Published: September 2023

Abbott Elementary, a mockumentary comedy series airing on ABC, examines the plight of an underfunded, underresourced elementary school in Philadelphia. In this article, we argue that Abbott Elementary is a compelling look inside an, albeit fictional, urban school located in the city of Philadelphia. The mockumentary form of the series positions the viewer as ethnographer so that we, in essence, engage in data collection as we listen to documentary-style interviews with participants. Using intersectional analysis, we ponder two questions: How does Abbott Elementary expand or constrain our thinking through systems of domination around the politics of schooling? How might Abbott Elementary further inform our understandings of damage-centered and desire-based research?
Treating Voices Carefully
Authors: Fowler Lucy
Published: September 2023

The Listening Guide method of (or voice-centered relational approach to) data analysis was developed to center marginalized voices in research, and this article outlines its use within the context of a research project with queer Métis youth. I explore this method as part of a Métis research paradigm, and walk through the process of analysis using this method, including outlining and explaining the process of listening for the plot, for the I voice, and for contrapuntal voices. This article adds to the development of the Listening Guide as a method and as part of an Indigenous research methodology.
Fenomenología y teatro:
Authors: Díaz Guzmán Omar David , Triana Moreno Diana
Published: September 2023

Los conceptos de percepción y corporalidad en la obra de Maurice Merleau-Ponty han influido los estudios sobre filosofía del teatro. La idea de la conciencia encarnada es relevante para comprender la experiencia corporal y expresiva en el contexto teatral, especialmente, para indagar en la relación que se presenta entre el espectador y la obra. Así, el obejtivo de este artículo es evidenciar cómo se configura el campo fenomenal en una obra teatral en dos momentos: primero, la comprensión del escenario como núcleo articulador de la experiencia en la que intervienen espacio, tiempo y movimiento; segundo, la relación entre el actor y el espectador en términos de la gestualidad y la palabra. Se demuestra que en el teatro hay una configuración generativa de sentidos colectivos conforme a la modulación del campo fenomenal.
Effect of the Information about the Use and Non-Use of Photoshopping of Female Ad Models on Brand Attitudes of Young Female Consumers
Authors: Pappenheim Christina , Gierl Heribert
Published: September 2023

There is a public debate about whether marketers should be required to provide information about photoshopping when they use idealized images of female ad models. Proponents of such information expect that this measure will counteract diminished self-esteem in young females and reduce consumer deceptions. In two experiments, we examine the effects of three factors: the depiction of female ad models in their idealized vs. Authentic appearance, the presence vs. absence of information that an idealized model has been digitally retouched, and the presence vs. Absence of information that a model shown in her authentic appearance has not been digitally retouched. We contribute to research as we focus on the impact on brand attitudes while previous research has mainly focused on the influence on self-esteem. We present new findings that could assist decisions in practice: For most beauty product categories, we find that non-extreme levels of model idealization result in highest brand attitudes. Information about photoshopping ad modelspromoting beauty products leads to lower brand attitude. Information about the non-use of photoshopping authentic ad models tends to result in higher brand attitudes.
La política educativa en tiempos turbulentos. Estado, desmercantilización y globalización
Authors: Carrasco-Bahamonde Juan Antonio , Carrasco-Bahamonde Daniel
Published: September 2023

El artículo explora un conjunto de abordajes conceptuales para aproximarnos al ciclo de restauraciones conservadoras en el campo educativo a partir de la clave interpretativa que ofrece el vínculo entre reestructuración del Estado y formación de política educativa en el marco de la globalización. Para esto, reconstruye un itinerario del debate conceptual en torno al estudio de la reforma educativa a partir de las contribuciones de la sociología de la política educativa. Finalmente, ofrece herramientas conceptuales para el análisis de los complejos escenarios de cambio que enfrentan los sistemas educativos y contribuir a una conceptualización más atenta al proceso de formación de las políticas educativas en tiempos de crisis neoliberal global.
O Mieib e o enfrentamento às políticas de Educação Infantil neoliberais e conservadoras do pós-golpe no Brasil
Authors: Uchôa Simões Patrícia Maria , Bengert Lima Juceli , Carvalho de Almeida Karla Wanessa , Vieira dos Santos Célia Maria
Published: September 2023

O estudo apresenta as políticas conservadoras propostas pelo governo federal após o golpe de 2016 e discute a atuação do MIEIB no enfrentamento a essas políticas. A análise foi fundamentada na teoria da atuação política proposta por Ball, Maguire e  Braun que compreende as políticas como estando sujeitas a processos de interpretação, tradução, recontextualização e recriação. Entre os diferentes atores que atuam nas políticas, estão os críticos, como o MIEIB, que manteve o contra-discurso vivo em seus documentos, reuniões e seminários. A análise se deu em documentos do MIEIB com posicionamentos em relação às políticas do governo federal. Como conclusão, assinalamos que o MIEIB vem reafirmando seus compromissos com a Educação Infantil, com os bebês e as crianças pequenas.
La alienación de la esperanza: el aprendizaje permanente y la educación de adultos en la política educativa europea (2000-2021)
Authors: Ramos Ramiro Marco
Published: September 2023

El presente artículo cuestiona la idea del aprendizaje permanente que ha dominado la política educativa europea durante los últimos veinte años y su influencia sobre la educación de adultos que se propone desde la UE, más orientada a hacer eficaz una estructura productiva neoliberal que a favorecer procesos de emancipación personal y ciudadana. Para ello, se analiza cómo se ha expresado el aprendizaje permanente dentro de la política educativa europea y su proyección en la educación de adultos. Por otro lado, el artículo propone una redefinición de las políticas de aprendizaje permanente y de educación de adultos en términos más justos y democráticos que permita enfrentar los retos que se derivan de la crisis ecosocial y sanitaria que vivimos actualmente.
El dolor social en tiempos de pandemia. Miedo y soledad de jóvenes estudiantes ante la pérdida de soportes afectivos
Authors: Szapu Ezequiel , Sulca Elisa Martina de los Ángeles , Arevalos Darío Hernán
Published: September 2023

Las emociones representan elementos centrales para comprender e intervenir sobre la trama escolar. El sufrimiento es constitutivo de la experiencia de época y las instituciones educativas se enfrentan al desafío de contribuir a elaborar y simbolizar el dolor individual y social. En este artículo analizamos las emotividades estudiantiles en el contexto de pandemia, a partir de los resultados de una encuesta autoadministrada realizada entre octubre y diciembre de 2020 a 2206 jóvenes que asisten a 15 escuelas secundarias públicas de gestión estatal ubicadas en zonas urbanas periféricas de la provincia de Buenos Aires, República Argentina. Asumimos que las emociones no se presentan en estado puro y que solo podemos acceder a ellas en su manifestación discursiva (Kessler, 2009). Nos centramos particularmente en las vivencias subjetivas vinculadas al miedo a la pérdida y a los sentimientos de soledad.
Complex ethics according to Edgar Morin: on hope and redemption
Authors: Speranza Maria Soledad
Published: September 2023

The present work consists of a bibliographic study carried out around the work of Edgar Morin and his developments referred to by him called complex ethics. It is fundamentally based on the contributions of volume VI of The Method (2016), with the aim of highlighting the ideas and relationships that were most disruptive and innovative precisely because they are the closest to the Human Condition. In his writing, the author distinguishes ethics from moral and begins with the strength of the idea that indicates that tolerance, by refusing intimidation, prohibition, anathema, gives primacy and opens the way to argument, reasoning, already the demonstration. And this is how Morin initially positions himself in this writing. While non-complex morality obeys a good-bad, fair-unfair binary code; complex ethics conceives that the good can contain an evil, the evil a good, the just the unjust and vice versa, and in recursion. It is an ethic that integrates contradictions and antagonisms and is never univocal. It moves away from the categorical Kantian imperatives and opens the possibility of a human ethics of uncertainty and of what it calls "ethical bet" to demonstrate how sometimes there must be a decision-making between ethical imperatives that enter into contradiction. It refers then to an objective understanding, a subjective one, and a complex one that integrates the previous ones.
Favorable treatment outcomes and shorter durations: a retrospective case series on seven patients using Orthoworld FASTBRACES®
Authors: Pagonis Tom C , Paunescu L. Adelina , Asumugha Evita , Harakaly Calia
Published: September 2023

Objective: This retrospective case series aimed to evaluate the effectiveness and user experience of Orthoworld FASTBRACES® in seven patients undergoing orthodontic treatment. Emphasizing these specific patients was essential for assessing the shorter treatment duration compared to reported treatment ranges of 12 to 14 months for FASTBRACES® Technologies. Data and images were collected from cases treated between 2016 and 2023, and a Treatment Evaluation Form was sent to participating doctors to gather information about patient experiences with the product. Materials and methods: The seven patients included in the study received orthodontic treatment with FASTBRACES® at various orthodontic practices. The Treatment Evaluation Form completed by participating providers included questions related to treatment details, number of visits, types of brackets and wires used, issues encountered during treatment, patient understanding of treatment, overall comfort level, compliance, and satisfaction with treatment speed. Results: The analysis of patient data revealed variability in patient compliance with treatment protocols and understanding of treatment, with scores ranging from 2 to 4 on the respective scales. The number of brackets used ranged from 10 to 28, and the number of wires utilized ranged from 1 to 4. Most patients reported minimal issues during treatment, with only one reported issue in two cases. Overall, patients reported a high level of comfort, with an average score of 3.43 out of 4. Conclusion: The findings highlight the importance of patient education and communication in promoting better compliance and treatment success. The variability in bracket and wire utilization suggests that the severity and complexity of malocclusions may influence the treatment approach. FASTBRACES® demonstrated success in minimizing patient discomfort, achieving faster alignment, and enhancing overall satisfaction. Further research is needed to investigate the factors underlying differences between the metal and ceramic bracket groups and explore mechanisms behind reported issues. The study underscores the significance of precise bracket and wire placement and the expertise of orthodontic practitioners throughout the treatment process. This case series provides valuable insights into the effectiveness and user experience of Orthoworld FASTBRACES® and lays the groundwork for future research and larger-scale studies.
Effectiveness of vestibular rehabilitation therapy (VRT) after persistent dizziness following sport-related concussion: a systematic review of the literature
Authors: Felipe Lilian , Pardue Caitlin , Michaels Marcella
Published: September 2023

Background: Vestibular Rehabilitation therapy (VRT) is an exercise-based treatment program designed to promote vestibular habituation, adaptation, and substitution. The goals of VRT are to enhance gaze stability, postural stability, and to improve activities of daily living. Dizziness and balance impairments are common following sport-related concussions; however, it is unclear how much impact VRT may have in the treatment for this population. Purpose: To conduct a systematic review to verify the application and outcomes of VRT after sport-related concussion with persistent dizziness and to determine the effectiveness of the treatment for sport-related concussion. Method: A systematic review of the following electronic databases was conducted: CINAHL Complete, PsycINFO, SPORTDiscus, Academic Search Complete, PUBMED, COCHRANE, and MEDLINE. The search ranged from January 2011 to April 2023. Results: 248 articles were found based on the specific search criteria. From them, 105 were selected and 54 records screened. After applying the criteria of inclusion and exclusion, four articles remained for examination. Conclusion: Vestibular rehabilitation therapy shows promise to improve dizziness and imbalance symptoms in those who have suffered sport-related concussions. As current return-to-play protocols do not account for adequate compensation of the vestibular system and may result in reinjury, vestibular rehabilitation may be able to assist the player’s recovery time, and in turn prevent reinjury; however, due to limited evidence, further studies are necessary to confirm these findings.
Obstructive sleep apnea syndrome
Authors: Delgado Juan Ivonne , Carmenates Lic.Isvel Perón
Published: September 2023

Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) is a frequent, chronic and progressive disorder. It is associated with increased cardiovascular, neurocognitive, and metabolic morbidity, risk of accidents, poor quality of life, and increased mortality. It affects 5% of the adult population, mainly men, and 2% of children between 4 and 5 years of age. Diagnosis is based on suspicion and joint evaluation of the clinical picture with appropriate confirmatory nocturnal studies such as polysomnography. The treatment has two fundamental objectives: to eliminate the respiratory obstruction and, therefore, the breathing stops (apneas) or the hypoventilations (hypopneas) and the drops in oxygen in the blood (desaturations) in any body position or phase of sleep and ensure that the subject sleeps well, improving their sleep quality and reducing or eliminating awakenings and micro-awakenings, which are the main causes of the symptoms.
REGULARITIES OF CHANGES IN THE ENERGY EFFICIENCY OF THE SUPERCAPACITOR DISCHARGE TO LINEAR ACTIVE LOAD WHEN THE DURATION OF THE DISCHARGE CHANGES
Authors:   Institute of Electrodynamics National Academy of Science of Ukraine,  Beresteiskyi ave., 56, Kyiv, 03057, Ukraine, Shcherba А.А. , Suprunovska N.І. ,   Institute of Electrodynamics National Academy of Science of Ukraine,  Beresteiskyi ave., 56, Kyiv, 03057, Ukraine, Belkin S.V. ,   Institute of Electrodynamics National Academy of Science of Ukraine,  Beresteiskyi ave., 56, Kyiv, 03057, Ukraine, Masluchenko I.M. ,   Scientific and Technical Center State Enterprise  "National Atomic Power Generating Company "Energoatom", Gogolivska St. 22-24, Kyiv-54, 01054, Ukraine
Published: September 2023

In the paper, the regularities of changes in electricity losses and the coefficient of its transfer to a linear active load during the discharge of a supercapacitor on the load under different conditions of interruption of discharge currents are determined. The influence of the conditions of interruption of discharge currents of the supercapacitor on the energy characteristics of the discharge circuit is determined, taking into account the fact that the capacity of the supercapacitor is a function of the voltage at its terminals. It was taken into account that this voltage can change its polarity. A mathematical model was developed that takes into account that the discharge process can be both aperiodic and oscillatory. The model was implemented in the Mat-lab/Simulink software package. A comparison of the energy characteristics during the discharge of a supercapacitor and a conventional linear capacitor on the same linear load at the same initial voltage on these capacitors was carried out. It has been established that the energy delivered to the load during the discharge of a supercapacitor is 1.8 times greater than dur-ing the discharge of a conventional linear capacitor charged to the same voltage, but the efficiency of energy transfer for these processes is almost the same. However, when the discharges of a supercapacitor and a conventional linear capacitor are forcibly interrupted, the efficiency of energy transfer to the load increases, and the efficiency during the discharge of the supercapacitor is always higher. Bibl. 14, fig. 3, tables 2. Key words: supercapacitor, capacitor, discharge, linear load, electricity losses, energy transfer efficiency.
Prospek Legalisasi Ganja Untuk Kebutuhan Medis
Authors: Abdurrachman Hamidah , Sudewo Fajar Ari , Idayanti Soesi
Published: September 2023

Ganja merupakan tanaman yang sering dipandang negatif. Penggunaan ganja dilarang oleh Undang-Undang Narkotika. Ganja dapat digunakan dalam bidang medis untuk pengobatan. Permasalahan yang dibahas dalam penelitian ini yaitu bagaimana pengaturan tentang ganja di Indonesia dan bagaimana prospek penggunaan ganja untuk kebutuhan medis di masa yang akan datang. Hasil penelitian menunjukan bahwa pengaturan tentang ganja terdapat dalam Undang-Undang Republik Indonesia Nomor 35 Tahun 2009 tentang Narkotika. Ganja di Indonesia digolongkan ke dalam jenis Narkotika Golongan I artinya ganja dapat dimanfaatkan untuk kepentingan ilmu pengetahuan dan teknologi. Ganja termasuk dalam Narkotika Golongan I yaitu dalam arti memiliki jerat hukuman yang paling berat yaitu 12 (dua belas) tahun. Penggunaan ganja untuk kebutuhan medis masih belum menemukan titik terang dalam ketentuan hukum di Indonesia. Hal tersebut dikarenakan adanya hambatan yaitu ganja dimasukan sebagai Narkotika Golongan I dalam Undang-Undang Republik Indonesia Nomor 35 Tahun 2009 tentang Narkotika karena tingkat ketergantungan Narkotika Golongan 1 sangat tinggi dan berbahaya untuk kesehatan. Adapun untuk pelegalisasian penggunaan ganja untuk kebutuhan medis di Indonesia yaitu dengan melakukan revisi pada Undang-Undang Republik Indonesia Nomor 35 Tahun 2009 tentang Narkotika dan mengeluarkan ganja dari Narkotika Golongan I.Kata Kunci : Legalisasi, Ganja, Medis
La guerra en los grupos sociales antiguos de Costa Rica: los artefactos arqueológicos a la luz de fuentes etnohistóricas y de tradición oral
Authors: Sánchez Avendaño Viviana , Sánchez Herrera Julio César , Sánchez Avendaño Carlos
Published: September 2023

En este artículo se discute la práctica de la guerra en los grupos sociales antiguos de Costa Rica a través del estudio de artefactos arqueológicos, fuentes etnohistóricas y relatos de tradición oral indígena. Primero, se reseñan algunas propuestas sobre el tema realizadas por profesionales en arqueología. Luego, se expone cómo se presenta la guerra tanto en fuentes históricas como en la tradición oral.  Finalmente, se interpreta la evidencia arqueológica con base en la estatuaria de las colecciones del Museo Nacional de Costa Rica, el Museo del Jade y de la Cultura Precolombina y el Museo del Oro Precolombino. El estudio resalta la importancia de la figura del guerrero dentro de la estratificación social de las sociedades pasadas, así como el hecho de que la guerra constituía una actividad constante y permanente entre los grupos.
Do Insular ao Peninsular
Authors: Bederode Igor Radtke
Published: September 2023

Este artigo é recorte de uma tese de Doutorado cuja indagação principal foi: “Como utilizar as tecnologias da informação e comunicação, à luz do pensamento complexo, na produção de práticas de ensino que potencializem a aprendizagem dos alunos da educação profissional e tecnológica, e, quais as reverberações oriundas deste movimento no conhecimento e no fazer docente?”. O estudo realizado trata-se de uma pesquisa de abordagem qualitativa, de objetivo exploratório, apoiada, em termos de procedimentos técnicos, por uma pesquisa-ação, com fundamento no pensamento complexo. Através de uma racionalidade aberta e complexa, foi possível delinear, com base no pensamento complexo, elementos teórico-metodológicos para produção de práticas de ensino mediadas pelas tecnologias da informação e comunicação (TIC), como forma de potencializar a aprendizagem dos alunos, e, numa lógica recursiva, própria do pensamento complexo, promover a análise das reverberações oriundas deste processo de pensar e concretizar práticas de ensino mediadas pelas TIC no conhecimento e no fazer docente, uma vez que os movimentos da pesquisa-ação realizada viabilizaram uma verdadeira formação docente entre pares.
Regional specialization and diversification of industries in Kazakhstan
Authors: Alibekova Gulnaz , Alzhanova Farida , Osmanov Zhasym , Omarov Akedil
Published: September 2023

This research aims to assess the degree of specialization and diversification in the regions of Kazakhstan. The method of calculating the location quotient is used to determine the degree of specialization of the regions. The industrial location quotient for three periods - 2010, 2015, and 2019 - is calculated to observe the dynamics of specialization of industries in the regions. The research identified sustainable, unstable, fading, and emerging. The degree of industrial diversification in the region is determined based on the number of sustainable industries in the region. The categorization of industries according to the dynamics of specialization makes it possible to apply various mechanisms and ways to recover fading industries and support unstable and emerging industries. The research results can be used in designing Kazakhstan's regional industrial and innovation policies.
Prinsip-Prinsip Humanisme Menurut Ali Syari'ati
Authors: Prawira Negara Muhammad Adres , Muhlas Muhlas
Published: September 2023

Islam has universal teachings, namely human values. Ali Shari'ati is one of the Islamic revolutionary thinkers who paid attention to humanism. According to him, humanism is a school of philosophy that views groups that aim to achieve perfection in humans. Ali Shari'ati emphasized that humans are creatures that have various values given by God. Humans are the most unique nature, because humans were created by God as the noblest creatures, have their own freedom, and are not controlled by something, so that humans can determine the direction of their lives freely and be responsible for their choices. This research aims to explore Ali Shariati's thoughts related to the principles of humanism. This research is a literature study that uses a qualitative approach with descriptive-analytic method. The result of this research is that according to Ali Shariati, humans as God's representatives on earth certainly have divine values that form moral, cultural and religious values. Then, in the principle of humanism built by Ali Shari'ati, he explained that there are seven basic concepts in Islamic humanism, including humans having autonomous elements, having freedom, thinking creatures, conscious creatures, creatures that have creativity, creatures that have desires, and creatures that have morals.
Tasawuf Akhlaki Haris Al-Muhasibi: Alternative Solutions to Face Problems in the Modernization Era
Authors: Erina Merita Dian , AK Riza Febriyanti , Nisa Isna Fitri Choirun , Darmalaksana Wahyudin
Published: September 2023

This study aims to discuss the Sufism of Akhlaki Haris al-Muhasibi as an alternative solution to the problems in the modernization era. A qualitative method with descriptive analysis is used as its research method. The results and discussion show that Sufism is one of the spiritual dimensions taught in Islam. It is divided into three types. One of them is akhlaqi Sufism. From Haris al-Muhasibi’s perprective, moral Sufism is the core of teachings that focus on promoting good values based on the Qur’an and Sunnah. This is suitable to be applied in the midst of the current modernization era, a time filled with spiritual dryness that resulted the loss of religious values and norms which then makes crime rampant. Furthermore, it can be concluded from this research that Haris al-Muhasibi's moral Sufism can be an alternative solution to overcome various problems in the modernization era. last but not least, this study recommends to all people to start implementing moral Sufism in everyday life in order to reduce various crimes that are increasing in this modern era.
Sufistic Values in Cupping Therapy from the Sufi Healing Perspective
Authors: Mahmudah Siti Aminatus , Muhammad Hasyim Muhammad
Published: September 2023

This study aims to discuss the value of Sufism in cupping Sufi healing perspective. This research uses a qualitative approach by applying the descriptive-analytical method. The formal object of this research is Sufi healing, while the material object is the Sufi values in cupping therapy. The results and discussion of this study are that there are Sufistic values in cupping therapy, namely mahabbah, gratitude, patience, ridha and tawakkal. This study concludes that based on the Sufi healing perspective, there are Sufistic values in cupping therapy. This study recommends Sufism enthusiasts to develop Sufi healing in cupping practices and cupping practitioners to incorporate Sufism values as Sufi healing in medicine and public health services in the country.
Afif Muhammad's Philosophy of Happiness Perspective
Authors: Ashikin Nur , Hambali Radea Yuli A , Hakim Maman Lukmanul
Published: September 2023

The purpose of this study is to examine happiness according to Afif Muhammad clearly, and how to achieve happiness. This research is a qualitative research. The method used is library research and interviews. The data sources used are Primary and Secondary Data. This study concludes that according to Afif Muhammad, happiness is an inner or mental situation that a person has in which a person feels calm, peaceful and safe and can also be felt by those around him. If someone has felt happiness then he will radiate that happiness to the people around him. He divided the stages of happiness into three categories: Lay level, Intermediate level, and Supreme Level. This division is not meant to distinguish the form of happiness but so that we can measure our level of happiness at which level. As for the factors that we must have to achieve happiness, namely: by having an honest nature and not hating anyone so that our lives become calm and can achieve true happiness.
Sects & Stats: Overturning the Conventional Wisdom about Cult Members
Authors: Lewis James R.
Published: September 2023

A major, perhaps the major, focus of early research on New Religious Movements (NRMs) was on the people who joined. Most of the field’s pioneer researchers were sociologists. However, the profile of NRM members had changed substantially by the twenty-first century – changes largely missed because the great majority of current NRM specialists are not quantitatively oriented. Sects & Stats aims to overturn the conventional wisdom by drawing on current quantitative data from two sources: questionnaire research on select NRMs and relevant national census data collected by Anglophone countries. Sects & Stats also makes a strong argument for the use of longitudinal methods in studying alternative religions. Additionally, through case studies drawn from the author’s own research projects over the years, readers will be brought into a conversation about some of the issues involved in how to conduct such research.
Complexity, Atomization and Utopian Pragmatism in Latin American Communicational Thought
Authors: Quiroga Sergio Ricardo
Published: September 2023

The creative wealth of Latin American communication studies has promoted the broadening of the object of study of communication, which has now exceeded two centuries, revealing collective realities and concerns about society and the media, processes that imply rethinking the link between thought, knowledge and academia. Complexity, fragmentation, atomization and utopian pragmatism distill authors such as Antonio Pascuali, Luiz Beltrão, José Marques de Melo and Jesús Martín-Barbero, who have built a theoretical and elastic mesh to think and rethink Latin American communicational thinking within the framework of complexity and the utopian pragmatism of a mestizo science under construction. Faced with the fragmentation of the communicational field, we perceive a deeply atomized terrain A riqueza criativa dos estudos da comunicação latino-americanos tem promovido a ampliação do objeto de estudo da comunicação, que já ultrapassou dois séculos, revelando realidades coletivas e preocupações com a sociedade e os meios de comunicação, processos que implicam repensar a ligação entre pensamento, conhecimento e academia. Complexidade, fragmentação, atomização e pragmatismo utópico destilam autores como Antonio Pascuali, Luiz Beltrão, José Marques de Melo e Jesús Martín-Barbero, que construíram uma malha teórica e elástica para pensar e repensar o pensamento comunicacional latino-americano no quadro da complexidade e o pragmatismo utópico de uma ciência mestiça em construção. Diante da fragmentação do campo comunicacional, percebemos um terreno profundamente atomizado.
O mal-estar da conexão espasmódica: da obediência à dependência?
Authors: Jorge Marianna Ferreira , Sibilia Paula
Published: September 2023

O uso "viciante" das tecnologias digitais de comunicação e informação é examinado, neste artigo, à luz da noção de "mal-estar" apresentada por Sigmund Freud em 1930. Recorrendo à perspectiva genealógica, considera-se que as transformações históricas ocorridas nas últimas décadas afetaram fortemente a configuração das subjetividades e os modos de sofrer, distanciando-se da civilização moderna que motivou as reflexões freudianas. Os sujeitos contemporâneos já não se reconhecem como aqueles cidadãos disciplinados da sociedade industrial, que em nome do “bem comum” aceitavam a submissão a uma autoridade internalizada, moral e legalmente consensuada, à qual era preciso obedecer reprimindo outros impulsos. Por isso, a inquietação que suscita a crescente dependência da conexão às redes informáticas, um ato individual e voluntário embora difícil de se (auto)controlar, constitui um caso exemplar para estudar essas importantes mudanças.
“Ensinar a todos, todas as coisas, totalmente”: a pedagogia pansófica de Comenius e seu telos utópico
Authors: Couto Vinicius
Published: September 2023

Iohannes Amos Comenius tem sido reconhecido como uma figura de importância nos estudos da educação, ao ponto de ser considerado o “Pai da Pedagogia moderna”. Sua perspectiva dos estudos educacionais se dá a partir da ótica do que ele denominou de pansofia, isto é, uma noção de democratização da educação em que se deve ensinar “tudo, a todos, totalmente”. No presente artigo, analisamos o que ele entendia por pansofia, como sua proposta se aplicava de maneira prática na didática escolar e como essa pansofia estava repleta de um telos utópico em prol de uma sociedade melhor, cujo meio para tal objetivo era a educação. Para tanto, utilizamos uma abordagem exploratória de suas obras Schola Ludus, Didactica Magna e Pampedia, em suas versões traduzidas para o português, analisando-as a partir da história das mentalidades numa dimensão da história da educação.
Apresentação do Dossiê - Inclusão e condição humana
Authors: Petraglia Izabel Cristina , Alves Maria Dolores Fortes , Hashizume Cristina Miyuki
Published: September 2023

O presente dossiê buscou apresentar e discutir o tema da educação inclusiva, de maneira abrangente e multidimensional, a partir de abordagens inter e transdisciplinares.
Formação de professores para a educação bilíngue de estudantes surdos: narrativas de professores de Pato Branco
Authors: Bica Luciana de Freitas , Marques Circe Mara , Pereira da Silva Madalena
Published: September 2023

A pesquisa objetivou problematizar quanto a formação inicial de professores, bem como conhecer as percepções dos professores da rede pública de ensino do município de Pato Branco, Paraná, quanto à educação bilíngue de estudantes surdos. A metodologia é de abordagem qualitativa, cujo instrumento de coleta de dados consistiu de um questionário respondido por 18 professores do ensino fundamental I e II. Os dados foram organizados e categorizados por meio da análise de conteúdo. Os resultados evidenciaram que a maioria dos professores expressa sentimento de frustração em relação à docência com estudantes surdos, atribuído às dificuldades de comunicação. Essa dificuldade, muitas vezes, restringe a interação direta com o estudante e delega ao intérprete a função de ensinar a criança surda, na contramão da legislação em vigor.
(AUTO)biografia: contribuições da autonomia e da criatividade para uma estudante surda no curso de Pedagogia
Authors: Simão Vera Lúcia , Zanotto Camila Pureza , Ferreira de Oliveira Adriana Da Silva , De Oliveira Thais
Published: September 2023

A presente pesquisa é parte do fruto de um trabalho de conclusão de curso de Pedagogia, da Universidade xxxxxxxxxxx e apresenta a experiência de vida e relato das práticas de atuação de uma professora Surda. E teve como objetivo geral, identificar evidências do desenvolvimento da autonomia e da criatividade no processo de formação inicial aplicadas na prática pedagógica, a partir de sua história de vida. Trata-se de uma pesquisa qualitativa com narrativa (Auto) biográfica descrita em forma de episódios, apoiada na pesquisa bibliográfica. Como resultado, a pesquisa apontou a importância do desenvolvimento da autonomia e da criatividade nos processos de formação inicial para sua aplicação na prática pedagógica, dando destaque as etapas da Polinização Psicopedagógica descritas por Torre (2019).
Formação humana, diversidade e inclusão: desafios no contexto da Educação Superior
Authors: Santiago Cinthia Brenda Siqueira , Teixeira Ricardo Antonio Gonçalves , Limonta Sandra Valéria
Published: September 2023

O artigo apresenta a síntese de uma pesquisa sobre inclusão no contexto da educação superior. O objetivo principal é compreender a importância da formação da comunidade acadêmica para a inclusão de estudantes considerados Público de Atenção da Educação Especial (PAEE), mais especificamente estudantes com Transtorno do Espectro Autista (TEA). Trata-se de uma pesquisa de natureza exploratória, de abordagem qualitativa, que empregou questionários e entrevistas semiestruturadas como procedimentos de coleta de dados, analisados e discutidos a partir dos pressupostos da Análise de Conteúdo. Os resultados apontam para a necessidade de formação da comunidade acadêmica para uma melhor compreensão das relações entre formação, educação, diversidade e inclusão, bem como para um atendimento mais humanizado e pedagogicamente orientado das necessidades e demandas dos estudantes PAEE.
Atletas com deficiência e natação: um mergulho inclusivo e transdisciplinar
Authors: Suanno João Henrique , Sobral Anna Clara Souza , Suanno Marilza Vanessa Rosa
Published: September 2023

Busca-se nesse artigo apresentar resultados da pesquisa intitulada “Natação sob a perspectiva da epistemologia da complexidade: uma prática criativa de transcendência para atletas com deficiência” (SOBRAL, 2023) e, assim, tratar a natação sob um olhar complexo e inclusivo via para o reconhecimento dos atletas com deficiência na relação transdisciplinar com a transcendência individual do atleta e os seus impactos no meio social, cultural e educativo na realidade brasileira. A pesquisa, de abordagem qualitativa, fundamentou-se em (SOBRAL, 2023), Alves (2015), Junior (2008), Bachelard (1998), Berge (1986), Kunz (2015), Moraes (2004), Morin (2003, 2015, 2010), Suanno (2014) e Torre (2004). E tem por base Sobral (2023) que relata sobre a importância das práticas aquáticas na vida dos atletas com deficiência, considerando percepções, emoções e sentimentos. Para os atletas, a natação amplia a relação com a vida, sociais, culturais, físicos e psíquicos, além de oportunizar interação social. Na pesquisa de Sobral (2023) estar em contato com a água revelou-se ser um momento de conexão com o corpo bio-psiquico-espiritual, capaz de desenvolver criatividade, intuição e diversas potencialidades do sujeito, enfim um fluir no mergulho transcendental que é nadar.
Study of Therapeutic Mechanisms of Puerarin against Sepsis-Induced Myocardial Injury by Integrating Network Pharmacology, Bioinformatics Analysis, and Experimental Validation
Authors: Li Yin , Feng Lei , Bai Lin , Jiang Hao
Published: September 2023

Myocardial injury is the most prevalent and serious complication of sepsis. The potential of puerarin (Pue) to treat sepsis-induced myocardial injury (SIMI) has been recently reported. Nevertheless, the specific anti-SIMI mechanisms of Pue remain largely unclear. Integrating network pharmacology, bioinformatics analysis, and experimental validation, we aimed to clarify the anti-SIMI mechanisms of Pue, thereby furnishing novel therapeutic targets. Pue-associated targets were collected from HIT, GeneCards, SwissTargetPrediction, SuperPred, and CTD databases. SIMI-associated targets were acquired from GeneCards and DisGeNET. Differentially expressed genes (DEGs) were identified from GEO database. Potential anti-SIMI targets of Pue were determined using VennDiagram. ClusterProfiler was employed for GO and KEGG analyses. STRING database and Cytoscape were used for protein-protein interaction (PPI) network construction, and cytoHubba was used for hub target screening. PyMOL and AutoDock were utilized for molecular docking. An in vitro SIMI model was built to further verify the therapeutic mechanisms of Pue. Seventy-three Pue-SIMI-DEG intersecting target genes were obtained. GO and KEGG analyses revealed that the targets were principally concentrated in cellular response to chemical stress, response to oxidative stress (OS), and insulin and neurotrophin signaling pathways. Through PPI analysis and molecular docking, AKT1, CASP3, TP53, and MAPK3 were identified as the pivotal targets. In vivo experiments indicated that Pue promoted cell proliferation, downregulated AKT1, CASP3, TP53, and MAPK3, and inhibited inflammation, myocardial injury, OS, and apoptosis in the cell model. Pue might inhibit inflammation, myocardial injury, OS, and apoptosis to treat SIMI by reducing AKT1, CASP3, TP53, and MAPK3.