bluuebunny/crossref_metadata_2025 huggingface dataset:
Genome-Based Assessment of Antimicrobial Resistance and Virulence Potential of Isolates of Non-Pullorum/Gallinarum Salmonella Serovars Recovered from Dead Poultry in China
Authors: Li Yan , Kang Xiamei , Ed-Dra Abdelaziz , Zhou Xiao , Jia Chenghao , Müller Anja , Liu Yuqing , Kehrenberg Corinna , Yue Min
Published: June 2022

Avian salmonellosis is one of the leading global causes of poultry death, resulting in substantial economic losses in China (constituting 9% of overall financial losses). In Shandong province, a top poultry producer (30% of the overall production in China, with 15% being exported to the world), extensive outbreaks of avian salmonellosis have been reported in the past decade where the causal agents or exact types remain rarely addressed.
Expression of the Bacillus thuringiensis
vip3A
Insecticidal Toxin Gene Is Activated at the Onset of Stationary Phase by VipR, an Autoregulated Transcription Factor
Authors: Chen Haibo , Verplaetse Emilie , Slamti Leyla , Lereclus Didier
Published: June 2022

The insecticidal properties of
Bacillus thuringiensis
are due mainly to Cry toxins which form a crystalline inclusion during sporulation. However, other proteins participate in the pathogenicity of the bacterium, notably, the Vip3A toxins that are produced from vegetative growth to sporulation.
Fifteen-minute consultation: Child with persistent runny nose
Authors: Powell Elizabeth , Berk Omer , Bewick Jessica , Zolkipli Zaraquiza Q
Published: June 2022

A child with persistent runny nose may cause significant parental anxiety and healthcare utilisation. While the most common diagnoses are recurrent acute viral upper respiratory tract infections and allergic rhinitis, a careful history and examination is necessary to exclude other causes and to identify comorbidities. Treatment can then be tailored to the underlying cause. The aim of this article is to provide a systematic approach to such patients.
L-5-hydroxytryptophan promotes antitumor immunity by inhibiting PD-L1 inducible expression
Authors: Huang Jing , Wang Xiaobo , Li Bing , Shen Shiyu , Wang Ruina , Tao Hongru , Hu Junchi , Yu Jin , Jiang Hualiang , Chen Kaixian , Luo Cheng , Dang Yongjun , Zhang Yuanyuan
Published: June 2022

Background

The repression or downregulation of programmed death-ligand 1 (PD-L1) can release its inhibition of T cells and activate antitumor immune responses. Although PD-1 and PD-L1 antibodies are promising treatments for diverse tumor types, their inherent disadvantages and immune-related adverse events remain significant issues. The development of small molecule inhibitors targeting the interaction surface of PD-1 and PD-L1 has been reviving, yet many challenges remain. To address these issues, we aimed to find small molecules with durable efficacy and favorable biosafety that alter PD-L1 surface expression and can be developed into a promising alternative and complementary therapy for existing anti-PD-1/PD-L1 therapies.

Methods

Cell-based screen of 200 metabolic molecules using a high-throughput flow cytometry assay of PD-L1 surface expression was conducted, and L-5-hydroxytryptophan (L-5-HTP) was found to suppress PD-L1 expression induced by interferon gamma (IFN-γ). Inhibition of PD-L1 induction and antitumor effect of L-5-HTP were evaluated in two syngeneic mouse tumor models. Flow cytometry was performed to investigate the change in the tumor microenvironment caused by L-5-HTP treatment.

Results

We discovered that L-5-HTP suppressed IFN-γ-induced PD-L1 expression in tumor cells transcriptionally, and this effect was directly due to itself. Mechanistically, L-5-HTP inhibited IFN-γ-induced expression of RTK ligands and thus suppressed phosphorylation-mediated activation of RTK receptors and the downstream MEK/ERK/c-JUN signaling cascade, leading to decreased PD-L1 induction. In syngeneic mouse tumor models, treatment with 100 mg/kg L-5-HTP (intraperitoneal) inhibited PD-L1 expression and exhibited antitumor effect. L-5-HTP upregulated the ratio of granzyme B+ CD8+ activated cytotoxic T cells. An intact immune system and PD-L1 expression was critical for L-5-HTP to exert its antitumor effects. Furthermore, L-5-HTP acted synergistically with PD-1 antibody to improve anticancer effect.

Conclusion

Our study illustrated L-5-HTP’s inhibitory effect on PD-L1 induction stimulated by IFN-γ in tumor cells and also provided insight into repurposing L-5-HTP for use in tumor immunotherapy.
Cancer cells resist antibody-mediated destruction by neutrophils through activation of the exocyst complex
Authors: van Rees Dieke J , Bouti Panagiota , Klein Bart , Verkuijlen Paul J H , van Houdt Michel , Schornagel Karin , Tool Anton T J , Venet David , Sotiriou Christos , El-Abed Sarra , Izquierdo Miguel , Guillaume Sébastien , Saura Cristina , Di Cosimo Serena , Huober Jens , Roylance Rebecca , Kim Sung-Bae , Kuijpers Taco W , van Bruggen Robin , K van den Berg Timo , Matlung Hanke L
Published: June 2022

Background

Neutrophils kill antibody-opsonized tumor cells using trogocytosis, a unique mechanism of destruction of the target plasma. This previously unknown cytotoxic process of neutrophils is dependent on antibody opsonization, Fcγ receptors and CD11b/CD18 integrins. Here, we demonstrate that tumor cells can escape neutrophil-mediated cytotoxicity by calcium (Ca2+)-dependent and exocyst complex-dependent plasma membrane repair.

Methods

We knocked down EXOC7 or EXOC4, two exocyst components, to evaluate their involvement in tumor cell membrane repair after neutrophil-induced trogocytosis. We used live cell microscopy and flow cytometry for visualization of the host and tumor cell interaction and tumor cell membrane repair. Last, we reported the mRNA levels of exocyst in breast cancer tumors in correlation to the response in trastuzumab-treated patients.

Results

We found that tumor cells can evade neutrophil antibody-dependent cellular cytotoxicity (ADCC) by Ca2+-dependent cell membrane repair, a process induced upon neutrophil trogocytosis. Absence of exocyst components EXOC7 or EXOC4 rendered tumor cells vulnerable to neutrophil-mediated ADCC (but not natural killer cell-mediated killing), while neutrophil trogocytosis remained unaltered. Finally, mRNA levels of exocyst components in trastuzumab-treated patients were inversely correlated to complete response to therapy.

Conclusions

Our results support that neutrophil attack towards antibody-opsonized cancer cells by trogocytosis induces an active repair process by the exocyst complex in vitro. Our findings provide insight to the possible contribution of neutrophils in current antibody therapies and the tolerance mechanism of tumor cells and support further studies for potential use of the exocyst components as clinical biomarkers.
Improving visualization of three-dimensional aneurysm features via segmentation with upsampled resolution and gradient enhancement (SURGE)
Authors: MacDonald Daniel E , Cancelliere Nicole M , Rustici Arianna , Pereira Vitor M , Steinman David A
Published: June 2022

Background

Intracranial aneurysm neck width tends to be overestimated when measured with three-dimensional rotational angiography (3DRA) compared with two-dimensional digital subtraction angiography (2D-DSA), owing to high curvature at the neck. This may affect morphological and hemodynamic analysis in support of treatment planning. We present and validate a method for extracting high curvature features, such as aneurysm ostia, during segmentation of 3DRA images.

Methods

In our novel SURGE (segmentation with upsampled resolution and gradient enhancement) approach, the gradient of an upsampled image is sharpened before gradient-based watershed segmentation. Neck measurements were performed for both standard and SURGE segmentations of 3DRA for 60 consecutive patients and compared with those from 2D-DSA. Those segmentations were also qualitatively compared for surface topology and morphology.

Results

Compared with the standard watershed method, SURGE reduced neck measurement error relative to 2D-DSA by >60%: median error was 0.49 mm versus 0.17 mm for SURGE, which is less than the average pixel resolution (~0.33 mm) of the 3DRA dataset. SURGE reduced neck width overestimations >1 mm from 13/60 to 5/60 cases. Relative to 2D-DSA, standard segmentations were overestimated by 16% and 93% at median and 95th percentiles, respectively, compared with only 6% and 37%, respectively, for SURGE.

Conclusion

SURGE provides operators with high-level control of the image gradient, allowing recovery of high-curvature features such as aneurysm ostia from 3DRA where conventional algorithms may fail. Compared with standard segmentation and tedious manual editing, SURGE provides a faster, easier, and more objective method for assessing aneurysm ostia and morphology.
Early versus delayed complete revascularisation in patients presenting with ST-segment elevation myocardial infarction and multivessel disease: a systematic review and meta-analysis of randomised controlled trials
Authors: Abouelmagd Khaled , Tayel Hesham , Atta Ashraf , Ladwiniec Andrew , Ibrahim Mokhtar
Published: June 2022

Background

Several studies have demonstrated that complete revascularisation improves clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI) and multivessel coronary disease. However, the optimal timing of non-culprit lesion revascularisation remains controversial.

Objective

The aim of this systematic review and meta-analysis was to assess the effect of timing of complete revascularisation on cardiovascular outcomes in patients with STEMI and multivessel coronary artery disease.

Methods

Searches of PubMed, the Cochrane Library, ClinicalTrials.gov and the reference lists of relevant papers were conducted covering the period from 2004 to 2019. A pairwise analysis was performed to compare the difference in clinical outcome between early complete revascularisation (index procedure or index hospitalisation) and delayed complete revascularisation (after discharge) in patients with STEMI.

The primary endpoint was the incidence of major adverse cardiac events (MACE), which was defined as the composite of all-cause mortality, recurrent myocardial infarction, unplanned repeated revascularisation and cardiovascular death.

Results

Twelve studies including a total of 7596 patients were identified. The MACE rate was 10.37% in early complete revascularisation compared with 18.17% in culprit only (p=0.01). When complete revascularisation was delayed, the MACE rate was 11.81% after complete revascularisation compared with 17.21% in culprit-only percutaneous coronary intervention (PCI) (p=0.01). A meta-regression analysis demonstrated no relationship between timing of complete revascularisation and reduction in MACE relative to culprit-only PCI (p=0.862).

Conclusion

In patients with STEMI treated by primary PCI and multivessel disease, there is a benefit of complete revascularisation over culprit-only PCI whether non-culprit revascularisation is performed early in hospital or delayed as an elective procedure. We have not demonstrated a relationship between timing of complete revascularisation and MACE.

PROSPERO registration number

CRD42021226789.
Hatchery propagation did not reduce natural steelhead productivity relative to habitat conditions and predation in a mid-Columbia River subbasin
Authors: Courter Ian I. , Chance Tom , Gerstenberger Ryan , Roes Mark , Gibbs Sean , Spidle Adrian
Published: June 2022

For over 150 years, hatchery-origin anadromous salmon and trout have been reared and released throughout the Pacific Northwest to mitigate for lost habitat and sustain harvest opportunity. Some studies demonstrate that introgression of hatchery and naturally produced fish may constrain conservation efforts through maladaptive genetic processes. However, empirical demonstrations of the influence of these genetic interactions on population productivity are lacking, making it difficult to assess their importance relative to other drivers of productivity. We estimated the effect of the proportion of hatchery-origin spawners (pHOS), proportionate natural influence (PNI), and hatchery fish releases on natural adult winter steelhead recruitment in the Hood River, Oregon, over a 27-year period of record. Adult winter steelhead productivity was not associated with pHOS and PNI. However, natural winter steelhead productivity was positively associated with ocean conditions, stream flow, and hatchery fish release numbers, while negatively associated with pinniped abundance. Our analysis highlights the importance of quantifying the influence of hatchery programs on fish production relative to environmental factors known to affect natural-origin anadromous fish recruitment.
Extremal charged black holes and superradiantly unstable quasinormal modes
Authors: Mai Zhan-Feng , Yang Run-Qiu , Lü H.
Published: June 2022

It was recently shown that the extremal charged black holes in STU supergravity suffer from superradiant instability owing to the existence of the unstable (low-frequency) quasibound states associated with a charged massive scalar field. In this paper, we show numerically that for some charge configurations, these black holes can also excite the (higher-frequency) superradiantly unstable quasinormal modes. We find empirically that the unstable modes are closely related to having a volcano-shaped effective potential in the Schrödinger-like wave equation.
Some generalizations of Satoh’s Tube map
Authors: Winter Blake K.
Published: June 2022

Satoh defined a map from virtual links to ribbon surfaces embedded in [Formula: see text]. Herein, we generalize this map to virtual [Formula: see text]-links, and use this to construct generalizations of welded and extended welded knots to higher dimensions. This also allows us to construct two new geometric pictures of virtual [Formula: see text]-links, including 1-links.
Seismic Active Pressure on an Inclined Retaining Wall with Surcharge on a Submerged Backfill
Authors: Srikar Godas , Mittal Satyendra
Published: June 2022

Seismic design of retaining wall supporting submerged retaining wall requires precise estimation of lateral earth pressure considering realistic parameters that constitute hydro-dynamic pressure, frequency inputs and other dynamic properties. The purpose of this study is to establish a closed-form solution for seismic lateral earth pressure acting on a retaining wall with submerged backfill with surcharge. The proposed method includes the dynamic nature by considering time-period, the frequency of the seismic wave, dynamic soil properties. Boundary conditions in the backfill are satisfied due to the propagation of the seismic wave. This study considers amplified seismic waves to estimate inertial forces due to critical soil mass and surcharge. The excess pore pressure generated during the seismic action is also considered in this study. The obtained formulation shows the significant effect of frequency content, damping resistance offered by backfill soil, amplification of seismic wave on seismic earth pressure. The seismic earth pressure obtained from this study is observed to be in a close agreement with centrifuge test results and analytical studies from the literature. This study definitely addresses the lateral pressure distribution on the retaining wall with backfill submergence and surcharge on the surface.
Governing Cross-Border Data Flows: China’s Proposal and Practice
Authors: Jiang Xudong
Published: June 2022

Beijing’s quest for a more prominent role in a changing international order requires greater ability to shape global rules and norms in emerging strategic domains like cyberspace. Cross-border data flows, an important driving force behind the digital economy, give rise to growing concerns about potential threats to national security and individual privacy. In contrast with the Western approach that focuses on maximum data freedom, China’s proposal for cross-border data governance prioritizes security, order, and development. Contrary to outside expectations that Beijing’s restrictive data policies allow little room for international alignment on data security governance, China has shown sufficient flexibility and open-mindedness in major international initiatives for norm setting and institution building. Moreover, Beijing insists that as a global common, cyberspace should not become a new battlefield of great power competition, but instead help advance the shared interests of developing nations.
Review of Novel Therapies and Update for Takayasu Arteritis and ANCA-Associated Vasculitis with Relevance to the Asia Pacific Region
Authors: Li Jing , Tian Xinping , Zeng Xiaofeng
Published: June 2022

The clinical studies of Takayasu’s arteritis and antineutrophil cytoplasm antibodies (ANCA)-associated vasculitis are very active in the Asia Pacific region. The results of these studies give us a more comprehensive understanding of these vasculitis, which may not only change the management and long-term prognosis of the disease, but also reduce complications and prolonged survival time. Therefore, we summarize the results of these studies that were led or actively participated by investigators in the Asia Pacific region from 2020 to 2021, mainly focusing on the clinical characteristics and management.
Brain implants get real
Authors: Greengard Samuel
Published: June 2022

Universities, and a growing number of companies, are producing brain-computer interfaces.
Expressive querying for accelerating visual analytics
Authors: Siddiqui Tarique , Luh Paul , Wang Zesheng , Karahalios Karrie , Parameswaran Aditya G.
Published: June 2022

Data visualization is the primary means by which data analysts explore patterns, trends, and insights in their data. Unfortunately, existing visual analytics tools offer limited
expressiveness
and
scalability
when it comes to searching for visualizations over large datasets, making visual data exploration labor-intensive and time-consuming. In this work, we introduce the problem of visualization search and highlight two underlying challenges of search enumeration and visualization matching. To address them, we first present our work on Zenvisage that helps enumerate large collections of visualizations and supports simple visualization matching with the help of an interactive interface and an expressive visualization query language. For more finegrained and flexible visualization matching, including search for underspecified and approximate patterns, we extend Zenvisage to develop ShapeSearch. ShapeSearch supports a novel
shape querying algebra
that helps express a large class of pattern queries that are hard to specify with existing systems. ShapeSearch exposes multiple specification mechanisms: sketch, natural-language, and visual regular expressions that help users easily issue shape queries, while applying query-aware and perceptually-aware optimizations to efficiently execute them within interactive response times. To conclude, we discuss a number of open research problems to further improve the usability and performance of both Zenvisage and ShapeSearch.
Exclusivity probes
Authors: Shasha Dennis
Published: June 2022

Probing for particles.
Pivotal Tuning for Latent-based Editing of Real Images
Authors: Roich Daniel , Mokady Ron , Bermano Amit H. , Cohen-Or Daniel
Published: June 2022

Recently, numerous facial editing techniques have been proposed that leverage the generative power of a pretrained StyleGAN. To successfully edit an image this way, one must first project (or invert) the image into the pretrained generator’s domain. As it turns out, StyleGAN’s latent space induces an inherent tradeoff between distortion and editability, i.e., between maintaining the original appearance and convincingly altering its attributes. Hence, it remains challenging to apply ID-preserving edits to real facial images. In this article, we present an approach to bridge this gap. The idea is
Pivotal Tuning
—a brief training process that preserves editing quality, while surgically changing the portrayed identity and appearance. In Pivotal Tuning Inversion, an initial inverted latent code serves as a pivot, around which the generator is fine-tuned. At the same time, a regularization term keeps nearby identities intact, to locally contain the effect. We further show that Pivotal Tuning also applies to accommodating for a multitude of faces, while introducing negligible distortion on the rest of the domain. We validate our technique through inversion and editing metrics and show preferable scores to state-of-the-art methods. Last, we present successful editing for harder cases, including elaborate make-up or headwear.
ConTesse: Accurate Occluding Contours for Subdivision Surfaces
Authors: Liu Chenxi , Bénard Pierre , Hertzmann Aaron , Hoshyari Shayan
Published: June 2022

This article proposes a method for computing the visible occluding contours of subdivision surfaces. The article first introduces new theory for contour visibility of smooth surfaces. Necessary and sufficient conditions are introduced for when a sampled occluding contour is valid, that is, when it may be assigned consistent visibility. Previous methods do not guarantee these conditions, which helps explain why smooth contour visibility has been such a challenging problem in the past. The article then proposes an algorithm that, given a subdivision surface, finds sampled contours satisfying these conditions, and then generates a new triangle mesh matching the given occluding contours. The contours of the output triangle mesh may then be rendered with standard non-photorealistic rendering algorithms, using the mesh for visibility computation. The method can be applied to any triangle mesh, by treating it as the base mesh of a subdivision surface.
Engineering Next-Generation CAR-T Cells: Overcoming Tumor Hypoxia and Metabolism
Authors: Gao Torahito A. , Chen Yvonne Y.
Published: June 2022

T cells engineered to express chimeric antigen receptors (CARs) have shown remarkable success in treating B-cell malignancies, reflected by multiple US Food and Drug Administration–approved CAR-T cell products currently on the market. However, various obstacles have thus far limited the use of approved products and constrained the efficacy of CAR-T cell therapy against solid tumors. Overcoming these obstacles will necessitate multidimensional CAR-T cell engineering approaches and better understanding of the intricate tumor microenvironment (TME). Key challenges include treatment-related toxicity, antigen escape and heterogeneity, and the highly immunosuppressive profile of the TME. Notably, the hypoxic and nutrient-deprived nature of the TME severely attenuates CAR-T cell fitness and efficacy, highlighting the need for more sophisticated engineering strategies. In this review, we examine recent advances in protein- and cell-engineering strategies to improve CAR-T cell safety and efficacy, with an emphasis on overcoming immunosuppression induced by tumor metabolism and hypoxia.
Reactive Sputtered Ir1−yNiyOxElectrocatalysts For The Oxygen Evolution Reaction in Alkaline Media
Authors: Coertzen D. , Levecque P. B. J. , Jones D. R. , Dunnill C. W. , Kriek R. J. , Falch A.
Published: June 2022

One drawback of alkaline water electrolysis (AWE) is the sluggish oxygen evolution reaction (OER) kinetics at the anode of the electrolyser and improvement of the anode material is still a necessity. Various Ir1−yNiyOxelectrocatalyst combinations were prepared by reactive sputtering and subjected to high-throughput electrochemical screening using a Au/SiO2wafer. The best performing electrocatalysts were identified and subjected to single electrode electrochemical and physical characterisation using glassy carbon disk electrodes as the substrate. Rotating disk electrode (RDE) analysis included linear sweep voltammetry (LSV) before and after short term chronopotentiometry (CP). Energy dispersive X-ray spectroscopy and X-ray photo-electron spectroscopy (XPS) confirmed the controlled synthesis of thin film electrocatalysts by utilising reactive sputtering, and confirmed Ir dissolution which occurred during CP measurements. Overall, the Ir1−yNiyOxelectrocatalyst combinations containing higher amounts of Ir (Ir92Ni8Ox, Ir68Ni32Oxand Ir62Ni38Ox) performed the best of the evaluated mixed metal oxide electrocatalysts. However, evident from this study was that excellent mass-specific activity (current per mass of noble metal) was not exhibited by the mixed metal oxides when compared to Ni.
K-Means Clustering Algorithm–Based Functional Magnetic Resonance for Evaluation of Regular Hemodialysis on Brain Function of Patients with End-Stage Renal Disease
Authors: Cheng Yan , Yu Yan
Published: June 2022

This research was to evaluate the effects of regular hemodialysis (HD) on the brain function of patients with end-stage renal disease (ESRD). Resting-state functional magnetic resonance imaging (rs-fMRI) based on improved k-means clustering algorithm (k-means) was proposed to scan the brains of 30 regular dialysis patients with end-stage renal disease (ESRD) (experimental group) and 30 normal volunteers (control group). The proposed algorithm was compared with the traditional k-means algorithm and mean shift algorithm and applied to the magnetic resonance scan of patients with ESRD on long-term regular HD. The results showed that the neuropsychological cognitive function (NSCF) evaluation result of the test group was much better than that of the control group, and the difference was statistically obvious (

P
<
0.05

). The results of blood biochemistry, Digit Symbol Substitution Test (DSST), and Montreal Cognitive Assessment Scale (MoCA) in the test group showed no statistical difference compared with those in the control group. The running time of the improved k-means algorithm was dramatically shorter than that of traditional k-means algorithm, showing statistical difference (

P
<
0.05

). Comparison among the improved and traditional k-means algorithm and mean shift algorithm suggested that the improved k-means algorithm showed a lower error rate for image segmentation, and the differences were statistically remarkable (

P
<
0.05

). In conclusion, the improved k-means algorithm showed better time efficiency and the lowest error rate in processing rs-fMRI images than the traditional k-means algorithm and mean shift algorithm, and the effects of regular HD on the brains of patients with ESRD were evaluated effectively.
Privacy-Aware Task Assignment for IoT Audit Applications on Collaborative Edge Devices
Authors: Liu Linyuan , Zhu Haibin , Chen Shenglei , Huang Zhiqiu
Published: June 2022

To meet the rapidly increasing demand for Internet of Things (IoT) applications, edge computing, as a novel computing paradigm, can combine devices at the edge of the network to collaboratively provide computing resources for IoT applications. However, the dynamic, heterogeneous, distributed, and resource-constrained nature of the edge computing paradigm also brings some problems, such as more serious privacy leakages and performance bottlenecks. Therefore, how to ensure that the resource requirements of the application are satisfied, while enhancing the protection of user privacy as much as possible, is a challenge for the task assignment of IoT applications. Aiming to address this challenge, we propose a privacy-aware IoT task assignment approach at the edge of the network. Firstly, we model the resource and privacy requirements for IoT applications and evaluate the resource satisfaction and privacy compatibility between edge devices and tasks. Secondly, we formulate the problem of privacy-aware IoT task assignment on edge devices (PITAE) and develop two solutions to the PITAE problem based on the greedy search algorithm and the Kuhn–Munkres (KM) algorithm. Finally, we conduct a series of simulation experiments to evaluate the proposed approach. The experimental results show that the PITAE problem can be solved effectively and efficiently.
Research on Innovative Development of Crossborder e-Commerce under the Background of Wireless Communication and Internet of Things
Authors: Sun Jiahui , Luo Ning
Published: June 2022

After the epidemic has entered the normalization stage, people’s demand for online shopping and transactions has gradually increased, crossborder e-commerce has also developed more rapidly, and wireless communication and Internet of Things technologies have also been further upgraded with the update of electronic equipment. Technology has increased the smoothness of communication between overseas and domestic, and the Internet of Things has provided technical support for crossborder e-commerce trade traceability, trade security, and supply chain management. However, at present, crossborder e-commerce still has imperfect logistics systems and passive transactions, low income, etc. In order to solve the existing problems, this paper takes Shenzhen as an example, through a combination of literature analysis and practical investigation, and on the basis of analyzing the existing problems of crossborder e-commerce, an innovative scheme of crossborder e-commerce combining wireless communication and Internet of Things technology is proposed. The test results of the innovative scheme show that, compared with the unimproved scheme, this scheme greatly improves the income of e-commerce enterprises.
An Intelligent Mechanism for COVID-19 Emergency Resource Coordination and Follow-Up Response
Authors: Sun Hongyan , Xu Wei , Yu Yinyun , Cai Guiyang
Published: June 2022

As a serious emergency in 2020, COVID-19 had a great impact on people’s lives. In this paper, short-term and long-term response to emergency supplies needs after the outbreak of COVID-19 in a region is studied. Firstly, a comparative study of different regional resource coordination options in the early stages of COVID-19 is conducted using a multiobjective decision-making approach to arrive at the optimal solution. Then, a system dynamics model is established for the follow-up development of the epidemic, to predict the long-term development trend of the epidemic, and to study the urgency of the needs of different materials in different periods. The results show that time and satisfaction are the two most important indicators in the decision-making of the material deployment programme in the early stages of an outbreak. In the long-term control of the epidemic, the number of patients with minor illnesses generally peaks around 20 days, while the number of patients with severe illnesses generally peaks around 40 days, providing a focus for the supply of supplies at different times in the actual development of the epidemic, in order to better and more effectively control the epidemic and reduce inefficient consumption of supplies.
Efficacy of Duhuo Jisheng Decoction for Treating Cold‐Dampness Obstruction Syndrome‐Type Knee Osteoarthritis: A Pooled Analysis
Authors: Zhao Jinlong , Liang Guihong , Pan Jianke , Yang Weiyi , Zeng Lingfeng , Liu Jun
Published: June 2022

Aim. The aim of this study is to provide evidence of the effect of Duhuo Jisheng decoction (DHJSD) on knee osteoarthritis (KOA) of the cold‐dampness obstruction syndrome type. Methods. We searched PubMed, Embase, the Cochrane Library, the China National Knowledge Infrastructure, the Wanfang database, and the China Biology Medicine for randomized controlled trials (RCTs) evaluating DHJSD or DHJSD combined with other conventional therapies (DHJSD group) compared to conventional therapy (control group) for cold‐dampness obstruction syndrome‐type KOA. We calculated the pooled odds ratio (OR), mean difference (MD), and 95% confidence interval (CI) using fixed‐ or random‐effects models. Results. Eleven RCTs, with a total of 895 patients, were included. The results showed that DHJSD could significantly improve the effective rate (OR = 3.13, 95%CI = 2.07 to 4.72, P < 0.001), reduce both the WOMAC (MD = −12.06, 95%CI = ‐16.34 to ‐7.79, P < 0.001) and VAS (MD = −1.02, 95%CI = ‐1.54 to ‐0.50, P = 0.0001) scores, and reduce the serum IL‐6 (MD = −0.80, 95%CI = ‐0.90 to ‐0.69, P < 0.001) and TNF‐α (MD = −2.49, 95%CI = ‐2.77 to ‐2.21, P < 0.001) levels during the treatment of cold‐dampness obstruction syndrome‐type KOA. The subgroup analysis showed that compared with glucosamine sulfate (GS) alone, DHJSD combined with GS significantly improved the effective rate (OR = 2.59, 95%CI = 1.19 to 5.65, P = 0.02) and reduced the WOMAC (MD = −13.83, 95%CI = ‐16.14 to ‐11.51, P < 0.001) and VAS (MD = −0.91, 95%CI = ‐1.27 to ‐0.55, P < 0.001) scores. DHJSD + warm‐needle acupuncture (WA) lowered the VAS score more than WA alone. There was no significant difference in the decrease in serum IL‐1β between the DHJSD and control groups. Conclusion. This study shows that DHJSD can improve the clinical efficacy and reduce the VAS and WOMAC scores in the treatment of cold‐dampness obstruction syndrome‐type KOA. Compared with GS or WA alone, the combined application of DHJSD with GS or WA could better reduce both the VAS and WOMAC scores.
Analysis of the Thermal Effects on the Behaviour of Steel Connection Beam Section
Authors: Srikanth Seelam , KJN Sai Nitesh , Rama Krishna Chunchu Bala , K Vasugi , Teja Cheerla Prabhu , Y Sesha Rao , Kumar Sanjeev , Lemu Dumesa Gudissa
Published: June 2022

Steel connection is utilized to link the beam and column. It moves the plastic hinge structure away at a predetermined distance from the face of the column. To lower the cross-sectional area of the beam flanges, several shape cuts (uniform, radius, taper, and straight cut) are available, and a piece of the beam flanges at the column face is purposefully intended to yield and plastic hinge. The use of a lowered beam section connection reduces stress absorption since the criteria for a strong column–weak beam are met. The ANSYS 14.5 software was used to model four types of reduced beam sections by decreasing the beam flange. In various patterns, fatigue behaviour was studied. The objective of this project is to evaluate the deformations, stresses and transient temperatures deformations, and stresses of the reduced beam section at static structural analysis. In comparison to other connections, steel connection reduced beam section ductile and dissipated energy more. A nonlinear finite element software was used, along with a static study of exhaustion responsiveness transient temperatures. The analysis is carried out to identify the thermal effects on the behaviour of material properties in the elastic and plastic regions. The members with cuts have performed superior in comparison with members without cuts.
Performance Evaluation Method of Library Knowledge Management Based on Data Mining
Authors: Huang Li , Han Yongjun , Yuan Aihua , Xiao Tao , Yu Yi , Wang Lifeng , Zhang Xiaomin , Zhan Hongchun , Zhu Hanmin
Published: June 2022

With the development of information technology and computer technology, the work of the library is becoming more and more digitized and networked. This article mainly studies the performance evaluation method of library knowledge management based on data mining. This paper uses attribute-oriented induction algorithm to mine generalized features. First, scan the entire data set to obtain different values of all attributes. Statistics, classification, and analysis of historical records help to understand the usage of books and periodicals and perform predictive analysis. This article uses statistical weighted weight calculation formula to calculate the library knowledge management ability evaluation index weight. The evaluation of the knowledge management ability of the library mainly adopts the questionnaire survey method, and the knowledge management status of the library is deeply understood in the form of interviews on the spot, and the obtained evaluation data and materials of the knowledge management ability of the library are organized and statistics. In order to prevent the model from remembering the patterns of the training set too deeply, to make the model more general, and to adapt to unknown data well, we use the test set to rest the model. The part of the data set that has not been used in the process of modeling and testing correction can be used to estimate the effect of the model, or to compare the effect of the model. For expert value, the value of the office is 1.02, which is approximately equal to 1, which means that the value and cost of the office are basically equal in the knowledge service of the library. The results show that the combination of knowledge management and university library management will help to form a systematic theoretical framework and behavioral model framework in the research of knowledge management models and strategies in university libraries.
Effects of the Layered Distribution Pattern on the Gas Flow Resistance through the Bed with the Multisize Irregular Particle for the Waste Heat Recovery
Authors: Zhang Sizong
Published: June 2022

The application of the sinter vertical cooling technology in the iron and steel industry is conducive to the realization of the double carbon in China. To reduce the energy consumption and improve the economy of the new process, the gas flow resistance in the sinter bed under the layered distribution pattern was experimentally studied. The gas flow resistance of most of the layered distribution modes is lower than that of the random distribution mode. Among all layered arrangement modes, the layered mode with the particle size increasing from the bottom-up has the lowest resistance, followed by the layered mode with the particle size decreasing from the bottom-up. These two modes ensure the feasibility of the application of the layered distribution pattern in the continuous production of the moving bed. Besides, increasing the number of layers benefits the reduction of the gas flow resistance, which has a more significant effect on the layered mode with the particle size increasing from the bottom-up. For the sinter mixture with the equivalent particle diameter of 11.45 mm, the gas resistance of the modes with the particle size increasing and decreasing from the bottom-up decreases by 11.71% and 8.26% with the layer number increasing from three to five, respectively. Also, the effect of the layered distribution pattern on the gas flow resistance progressively weakens with increasing the equivalent particle diameter. For the five-layer distribution mode with the particle size increasing from the bottom-up, the gas resistance decreases by 2.72% with the equivalent particle diameter increasing from 11.45 mm to 15.45 mm, while that decreases by 4.61% with the equivalent particle diameter increasing from 15.45 mm to 19.45 mm. What's more, the change of the equivalent particle diameter has a more significant influence on the layered mode with the particle size decreasing from the bottom-up. With the equivalent particle diameter increasing from 15.45 mm to 19.45 mm under the five-layer distribution pattern, the gas resistance of the layered mode with the particle size increasing from the bottom-up reduces by 4.61%, while that of the mode with the particle size decreasing from the bottom-up reduces by 7.38%.
Chebyshev-Type Inequalities Involving (
k
,
ψ
)-Proportional Fractional Integral Operators
Authors: Yewale Bhagwat R. , Pachpatte Deepak B. , Aljaaidi Tariq A.
Published: June 2022

Expanding the analytical aspect of mathematics enables researchers to study more cosmic phenomena, especially with regard to the applied sciences related to fractional calculus. In the present paper, we establish some Chebyshev-type inequalities in the case synchronous functions. In order to achieve our goals, we use

k
,
ψ

-proportional fractional integral operators. Moreover, we present some special cases.
An Investigation in Applying Internet of Things Approach in Safe Food Dietary Plan for Better Chronic Diabetes Management among Elderly Adults
Authors: Geetha G. , Radeep Krishna R. , Vyas Swati , Sukhwal Isha , Jain Ankit , Chaturvedi Abhay , Shah Mohd Asif
Published: June 2022

Chronic diabetes among adults is a public health concern and clinicians are trying to implement new strategies to effectively manage the disease. Traditionally, healthcare professionals are used to monitor and track the lab reports of patients. After that, they used to provide respective medicines and lifestyle plans to manage the chronic disease. The lifestyle of the patients and access to safe and secure food products is also responsible for developing chronic diseases. Thus, the Internet of Things (IoT) has taken an utmost interest in managing diabetes. This research is going to analyze the accuracy of IoT in assisting chronic diabetes management and determining food safety. To accomplish the research objectives, the researchers performed a linear regression analysis to understand whether IoT devices and Artificial Intelligence (AI) assist in assessing food safety and diabetes management. The independent variables selected were lab test values, treatment records, epoch size of AI, and image resolution of the training dataset. Dependent variables were the accuracy of IoT. Here, the accuracy of IoT and AI has been determined. Moreover, the accuracy of clinicians in diabetes management has been observed. It has been found that clinicians have high variance in accuracy (max 99%) whereas machines have limited variance in accuracy (max. 98%). Secondary research identified that clinicians need to be involved along with IoT devices for better management of this chronic disease and help patients by providing the safest food options.
Evaluation of Antidiabetic and Antihyperlipidemic Activity of 80% Methanolic Extract of the Root of Solanum incanum Linnaeus (Solanaceae) in Mice
Authors: Andargie Yared , Sisay Woretaw , Molla Mulugeta , Tessema Getaye
Published: June 2022

Background. Conventional antidiabetic drugs are linked with a number of contraindications and untoward effects. The root decoction of Solanum incanum L. has traditionally been used to treat diabetes. However, its safety and efficacy have not been scientifically authenticated yet. Hence, the study was conducted in mice to corroborate its antidiabetic potential and safety profile. Methods. Using normoglycemic, oral glucose-loaded, and streptozotocin-induced diabetic mice models, the hypoglycemic and antihyperglycemic activities of 80% methanolic root extract were investigated. On streptozotocin-induced diabetic mice, the effect of the test extract on diabetic lipid profile and body weight was also investigated. Further, the in vitro α-amylase inhibition activity was assessed. Results. The test extract was safe at a limit test dose of 2 g/kg. Dose-dependent α-amylase inhibition activity was seen with peak percentage inhibition of 75.95% at 700 μg/mL. In normoglycemic mice, the plant extract showed statistically significant hypoglycemic activity at 200 and 400 mg/kg (P<0.001) at 6  h and 4 and 6 h of treatment, respectively; in oral glucose-loaded mice, at both the test doses, the glucose level was also significantly dropped at 120 (P<0.01) and 60 and 120 min (P<0.001), respectively; whereas, in the third model, the test extract showed significant antihyperglycemic activity at 100 mg/kg (P<0.05) on the 14th day and at 200 (P<0.01) and 400 mg/kg (P<0.001) on the 7th and 14th day of treatment. Similarly, following repeated administration of the test extract at 200 and 400 mg/kg, the body weight was significantly improved on the 14th day (P<0.05) and on the 7th and 14th day (P<0.01), respectively, while diabetic dyslipidemia after 14 days (P<0.05). Conclusion. The study revealed that the test extract showed promising antihyperglycemic and antihyperlipidemic activity. Thus, the findings back up its use in Ethiopian remedies for diabetes.
Cinnamaldehyde Mitigates Atherosclerosis Induced by High-Fat Diet via Modulation of Hyperlipidemia, Oxidative Stress, and Inflammation
Authors: Ismail Basma S. , Mahmoud Basant , Abdel-Reheim Eman S. , Soliman Hanan A. , Ali Tarek M. , Elesawy Basem H. , Zaky Mohamed Y.
Published: June 2022

Atherosclerosis is a disease in which plaque builds up inside arteries. Cinnamaldehyde (Ci) has many biological properties that include anti-inflammatory and antioxidant activities. Thus, this study was designed to explore the protective effect of Ci against atherosclerosis induced by a high-fat diet (HFD) in Wistar rats. Atherosclerosis was induced by an oral administration of an HFD for 10 weeks. Atherosclerosis-induced rats were supplemented with Ci at a dose of 20 mg/kg bw dissolved in 0.5% dimethyl sulfoxide (DMSO), daily by oral gavage for the same period. Rats were divided into three groups of 10 rats each fed with (a) ND, (b) HFD, and (c) HFD+Ci, daily for 10 weeks. Treatment of rats with Ci significantly reduced the elevated levels of serum total cholesterol (T.Ch), triglycerides (TG), low-density lipoprotein-cholesterol (LDL-Ch), very low-density lipoprotein-cholesterol (VLDL-Ch), and free fatty acids (FFAs) and significantly increased the lowered levels of high-density lipoprotein-cholesterol (HDL-Ch) level. Ci ameliorated the increased cardiovascular risk indices 1 and 2 and the decreased antiatherogenic index. Moreover, Ci reduced the elevated serum creatine kinase (CK), creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), and aspartate aminotransferase (AST) activities. Ci also improved the heart antioxidant activities by decreasing malondialdehyde (MDA) and increasing glutathione S-transferase (GST), superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), and glutathione peroxidase (Gpx) activities. Furthermore, the supplementation with Ci downregulated the mRNA expression levels of interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-17 (IL-17), and tumor necrosis factor-α (TNF-α). Thus, Ci successfully elicited a therapeutic impact against atherosclerosis induced by HFD via its hypolipidemic, antioxidant, and anti-inflammatory actions.
[Retracted] A Study on Parents’ Attitudes towards Middle School Students’ Online Learning Based on Statistical Analysis
Authors: Chen Guomin , Zheng Shihui , He Jianwu , Wang Xiaowei
Published: June 2022

Based on the role separation scenario in which students need parental support, this paper explores the effect of parents’ attitude on secondary school students’ online learning. Through structural equation model analysis and regression analysis of 745 valid responses to a questionnaire, the data results show that parents’ subjective dimension includes perceived gain and perceived loss, and social factor dimension includes teachers’ influence and online comments. Perceived value is the key influencing factor of parents’ attitude towards secondary school students in online learning platform. Perceived usefulness and platform information influence parents’ attitude positively and significantly, while perceived risk influences parents’ attitude negatively and significantly. In the dimension of social factors, teachers’ influence positively influences parents’ attitude, and online comments modulate the influence of perceived value on parents’ attitude.