bluuebunny/crossref_metadata_2025 huggingface dataset:
Gynaecological issues in women with bleeding disorders: CSL Behring Symposium
Authors: Batorova Angelika , Galen Karin van , Mackensen Sylvia von , Tsimpanakos Ioannis , Grimberg Evelyn
Published: April 2021

The symposium focused on issues around surgery, ovulation bleeding, health-related quality of life (HRQoL) and pelvic pain in women with bleeding disorders.

Surgery

Young women with congenital bleeding disorders, especially those with severe forms, are more likely to experience gynaecological and obstetric disorders than unaffected women. Surgery may be required to manage heavy menstrual bleeding (HMB), ovulatory bleeding, endometriosis and delivery. Major surgery should be undertaken only in hospitals with a haemophilia centre and 24-hour laboratory capability. Correction of haemostasis, either by desmopressin, coagulation factor or platelet transfusion, is essential for a successful outcome of surgery. Management of pregnancy requires a multidisciplinary approach; the mode of delivery is based on the consensus of gynaecologist and haematologist, and with respect to the patient’s diagnosis.

Ovulation bleeding

Women with bleeding disorders are at risk for excessive gynaecological bleeding associated with menstruation, ovulation, pregnancy and delivery. Ovulation bleeding is associated with the rupture of ovarian cysts and causes abdominal pain; complications include haemoperitoneum, fertility problems and ovarian torsion. Management includes hormonal and haemostatic therapies, in combination if necessary, and surgery as a last resort. Current management is based on experience in a relatively small number of cases and more clinical data are needed.

Health-related quality of life

In addition to experiencing joint and tissue bleeds, women experience psychosocial and medical issues associated with menstruation, pregnancy, labour and delivery. HMB has the greatest impact, and is associated with impaired HRQoL in almost all and dissatisfaction with the burden of treatment. There is a need for focused psychosocial support and a specific tool for the assessment of HRQoL in women with bleeding disorders.

Pelvic pain

Gynaecological causes of pelvic pain in women with bleeding disorders include dysmenorrhoea, mid-cycle pain, bleeding into the corpus luteum and endometriosis. There is no correlation between bleeding tendency and endometriosis severity; however, screening for a bleeding disorder should be considered. Pharmacological management may be hormonal or non-hormonal. Gonadotrophin-releasing hormone agonists offer an alternative to surgery for women with severe bleeding disorders who have endometriosis. Paracetamol is the preferred early analgesic option. Endometrial ablation controls heavy bleeding and pelvic pain but is not recommended for women with large fibroids or a large endometrial cavity. Hysterectomy is an option of last resort. Education for health professionals should include raising awareness about the management of pain in women with bleeding disorders.
Perfil epidemiológico dos casos com microcefalia atendidos em maternidade de alto risco em Sergipe
Authors: Almeida Andria Silveira , Da Silva Elaine Ferreira , Figueredo Rodrigues dos Santos Ravena dias , Fontes Almeida Thaynara , Kelly Fraga Oliveira Fernanda , Melo Prado Lourivânia Oliveira
Published: April 2021

OBJETIVO: Delinear o perfil epidemiológico dos casos atendidos com microcefalia em uma maternidade de alto risco no estado de Sergipe no ano de 2015. MATERIAIS E MÉTODOS: Trata-se de um estudo descritivo quantitativo dos casos de microcefalia em nascidos vivos de mães residentes no estado de Sergipe. Foi desenvolvido em uma maternidade pública de referência para gestantes e recém-nascidos de alto risco do município de Aracaju - Sergipe. A amostra selecionada por conveniência foi composta por 57 prontuários de casos de recém-nascidos microcefálicos. RESULTADOS: Em relação ao perfil dos recém-nascidos, 56,14% eram do sexo feminino, 85,96% tinham perímetro cefálico <32 cm, 82,45% Ápgar1` ? 7, 92,98% Ápgar 5 ?7 e  82,45% peso normal (2500-3999g). Quanto às características sociodemográficas das genitoras,  49,12% tinham entre 21 a 30 anos, 96,49% raça/cor parda,  26,3% ensino fundamental incompleto e  77,19% ocupação de doméstica. Durante o pré-natal, 8,77% realizaram exames de STORCH, 7,01% o exame de zika vírus, 8,77% exame para chikungunya e 3,50% sorologia para dengue. Em 2015, a microcefalia no estado foi considerada emergência de importância nacional. CONCLUSÃO: Houve predomínio de recém-nascido do sexo feminino e com perímetro cefálico <32. A maioria das genitoras eram adultas e com baixas condições socioeconômicas.
Digital Economy
Authors: Abdrakhmanova Gulnara , Vishnevskiy Konstantin , Gokhberg Leonid , Demidkina Olga , Demyanova Anna , Kovaleva Galina , Kotsemir Maxim , Kuznetsova Irina , Leven Ekaterina , Ozerova Olga , Polyakova Valentina , Ratay Tatyana , Ryzhikova Zinaida , Streltsova Ekaterina , Suslov Anton , Utyatina Kristina , Fridlyanova Svetlana , Fursov Konstantin , Schugal Nikolay
Published: April 2021

This pocket data book contains the most recent statistical data representing the level and dynamics of the digital economy development in the Russian Federation. International comparisons are provided for a number of indicators. The data book includes information of the Ministry of Digital Development, Communications and Mass Media of the Russian Federation, Russian Federal State Statistics Service (Rosstat), Russian Central Bank (Bank of Russia), Organisation for Economic Co-operation and Development (OECD), European Statistical Office (Eurostat), International Telecommunication Union (ITU), United Nations Conference on Trade and Development (UNCTAD), UN Department of Economic and Social Affairs, World Intellectual Property Organisation (WIPO), Scopus database, and results of own methodological and analytical studies of the HSE Institute for Statistical Studies and Economics of Knowledge. In some cases, the presented data specify those published earlier.
Индикаторы науки: 2021
Authors: Гохберг Леонид , Дитковский Кирилл , Евневич Евгения , Коцемир Максим , Кузнецова Ирина , Мартынова Светлана , Нефедова Алёна , Полякова Валентина , Ратай Татьяна , Росовецкая Лариса , Сагиева Галина , Стрельцова Екатерина , Суслов Антон , Тарасенко Ирина , Фридлянова Светлана , Фурсов Константин , Варзановцева Ирина , Пахомов Сергей
Published: April 2021

Предлагаемый статистический сборник продолжает серию публикаций, посвященных различным аспектам развития науки в Российской Федерации. Открывают сборник таблицы, в которых наряду с основными показателями науки и технологий представлены основные показатели инновационной деятельности. Отражены также основные показатели науки и технологий Арктической зоны Российской Федерации. Приводятся статистические данные о составе организаций, выполнявших исследования и разработки, кадрах и финансировании науки, ее материально-технической базе. В отдельных разделах содержатся сведения об интеллектуальной собственности, коммерциализации и использовании технологий, данные международных сопоставлений. В сборнике использованы материалы Федеральной службы государственной статистики, Министерства науки и высшего образования Российской Федерации, Федеральной службы по интеллектуальной собственности, Межгосударственного статистического комитета СНГ, Организации экономического сотрудничества и развития, Европейской комиссии, Евростата, ЮНЕСКО, Всемирной организации интеллектуальной собственности, а также методологические и аналитические разработки Института статистических исследований и экономики знаний Национального исследовательского университета «Высшая школа экономики». В ряде случаев данные по отдельным показателям уточняют ранее опубликованные.
GASTRIC METASTASIS OF RENAL CELL CARCINOMA: A CASE REPORT
Authors: ERKILINÇ Gamze , BİRCAN Sema , BAŞPINAR Şirin , EVRİMLER Şehnaz , ŞENOL Altuğ , ERTUNÇ Onur , ÇETİN Bülent
Published: April 2021

Primary gastric tumors are encountered more frequently

than metastatic tumors. The gastric metastasis of clear

cell renal cell carcinoma (CCRC) is very rare. We

herein report a case of gastric metastasis of CCRC.

A sixty-year-old man patient underwent a radical

nephrectomy and received adjuvant chemotherapy.

Pulmonary metastasis occurred at the second-year

follow-up, and interferon alpha-2a was used for

relapse. The Computed Tomography examination of

the patient presented with dyspepsia two years after

pulmonary metastases revealed 11 mm thickness in

the (along) gastric wall. Endoscopic examination was

suggestive of a neuroendocrine tumor.

Histopathologic evaluation of endoscopic biopsies

showed tumoral cell groups in a solid pattern composed

of clear, vacuolated cytoplasm. These tumor cells

were positive for RCC, PAX8 CD-10, Vimentin, and

immunohistochemistry findings were similar to the

initial tumor at diagnosis. Finally, the patient was

diagnosed with CCRC's gastric metastasis and treated

with a multi-targeted receptor tyrosine kinase inhibitor.
COVID-19 Tedavisinde Vitamin C ve D
Authors: ÜNAL Onur
Published: April 2021

Coronavirüs hastalığı 2019 (COVID-19) SARS-CoV-2 virüsünün neden olduğu asemptomatik seyirden, solunum yetmezliğinin eşlik ettiği ve ölümle sonuçlanabilen geniş spektrumda klinik tabloya yol açan hastalıktır. Korunma ve tedavisinde etkinliği kanıtlanmış seçenek sayısı sınırlıdır. Viral enfeksiyonlar sırasında vitamin ve mineral eksiklikleri olumsuz klinik sonuçlarla ilişkilendirilmektedir. Vitamin takviyesinin akut solunum yolu enfeksiyonu insidansını ve şiddetini azaltabileceğini belirten klinik çalışmalar mevcuttur. COVID-19 pandemisiyle birlikte vitaminlerin hastalıktan korunma ve tedavideki yararlarıyla ilgili araştırmalar artmış olup etkin olduğunu bildiren yayınlar kadar, bu sonucu desteklemeyen çalışmaların da olduğu gözlenmektedir. D vitamininin virüslere karşı fiziksel bariyerin güçlendirilmesinde, antimikrobiyal peptitlerin üretiminin uyarılmasında ve inflamatuvar sitokin üretiminin azalmasını sağlayarak sitokin fırtınalarının önlenmesinde önemli rolü olduğu belirtilmektedir. Vitamin C uygulamasının COVID-19 hastalarında immün yanıtın güçlendirilmesine katkıda bulunarak sağ kalım oranlarını arttırabileceği ifade edilmektedir. Bu derlemenin amacı COVID-19 hastalığında C ve D vitaminlerinin yararının değerlendirilmesidir.
publication 2 7.4 doi v1
Authors: Guliakina Mariia
Published: April 2021

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document 2 v1
Authors: Guliakina Mariia
Published: April 2021

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TNF IP for MS v1
Authors: Forte Eleonora , KRG KRG Research Group Kelleher , Drown Bryon
Published: April 2021

TNF IP protocol for mass spec analysis
Eine systematische Bewertung der Qualität von Simulationsmodellen
Authors: Barth Mike , Rosen Roland , Kübler Karl , Jäkel Jens , Ristić Mirjana , Heinzerling Till , Scheifele Christian
Published: April 2021

Die Bewertung der Qualität von Simulationsmodellen bildet nach wie vor eine grundsätzliche Herausforderung in allen Phasen des Anlagen- und Produktlebenszyklus. Gleichzeitig wird eine objektive und möglichst breit einsetzbare Qualitätsmetrik dann notwendig, wenn ein Simulationsmodell ein Teil der Lieferung einer Anlage oder ihrer Komponenten wird und als wesentlicher Bestandteil des Digitalen Zwillings über den gesamten Lebenszyklus weiterentwickelt wird. Im ersten Teil dieses Beitrages „Identifikation und Clustering von Qualitätskriterien“ (atp magazin 6/7-2020) wurden Attribute identifiziert, welche als maßgebliche Grundlage für die Bewertung der Qualität von Simulationsmodellen dienen. In diesem zweiten Beitragsteil werden unterschiedliche Bewertungsmechanismen eingeführt, mit deren Hilfe eine quantifizierte Einordnung in unterschiedliche Qualitätsniveaus möglich wird. Darüber hinaus beschreibt der Beitrag die aus der Validierung der komplettierten Metrik gewonnenen Erkenntnisse und zeigt den weiteren Entwicklungs- und Diskussionsbedarf auf.
Palača Slavenske banke u Vlaškoj ulici u Zagrebu
Authors: Topić Anamarija
Published: April 2021

U članku je obrađena palača Slavenske banke na križanju Vlaške i Draškovićeve ulice u Zagrebu. Palača je izgrađena između 1921. i 1923. godine prema projektu arhitekta Huga Ehrlicha, u stilu međuratnog klasicizma. Istraživanje se temelji na sačuvanom arhivskom gradivu, člancima iz dnevnog tiska iz doba gradnje, građevinskim nacrtima, starim fotografijama te relevantnoj stručnoj literaturi. Rezultati istraživanja omogućuju uvid u tijek gradnje i opremanja poslovno-stambene zgrade Slavenske banke.
Medaljerska dionica u briselskom opusu kipara Oscara Nemona
Authors: Zec Daniel
Published: April 2021

Rad se bavi medaljerskom dionicom u opusu kipara Oscara Nemona (1906. – 1985.) tijekom umjetnikova djelovanja u Bruxellesu u razdoblju od 1925. do 1936. godine. Razmatraju se tipološke, tehničke te stilsko-morfološke odlike Nemonovih medalja. Analizira se i vrednuje doprinos Oscara Nemona belgijskom modernom medaljerstvu u razdoblju između dvaju svjetskih ratova te se zaključuje kako je Nemon obogatio belgijsku likovnu scenu inovativnim i smjelim modernističkim rješenjima u art déco stilu koja počivaju na geometrijskoj stilizaciji forme.
O rekonstrukcijskim zahvatima na šibenskom kaštelu sv. Mihovila
Authors: Glavaš Ivo
Published: April 2021

U radu se donosi osvrt na radove obnove šibenskog kaštela sv. Mihovila koji su službeno završeni u lipnju 2014. godine. Analiziraju se konzervatorsko-restauratorski metodološki postupci koji su doveli do radikalnih rekonstrukcijskih zahvata na obrambenim bedemima i na podzidu tvrđave te kojima je došlo do uklanjanja ili poništavanja dijela izvornih povijesnih slojeva tvrđave iz razdoblja ranog novog vijeka.
Radovi profesora i učenika Privremene više škole za umjetnost i umjetni obrt pri izgradnji Kraljevske sveučilišne knjižnice i Zemaljskog arhiva u Zagrebu
Authors: Novina Ariana
Published: April 2021

Na temelju novopronađene arhivske građe autorica dopunjuje ranija istraživanja o opremanju Kraljevske sveučilišne knjižnice u Zagrebu (1911. – 1913.). U članku se spominju izvođači radova, profesori Privremene više škole za umjetnost i umjetni obrt, Rudolf Valdec i Robert Frangeš, te se atribuiraju novi izvođači – učenici Više škole kiparskog tečaja: Vojta Braniš, Ferdo Ćus, Davorin Hotko, Robert Jean, Milorad Jovanović, Hinko Juhn, Antonija Koščević, Rudolf Spiegler, Antun Štefić, Mila Wodsedalek. Članak obrađuje i doprinos Ljevaonice za broncu pri višoj školi za umjetnost i umjetni obrt pri gradnji knjižnice, koja je izvela ukrasne radnje iz bronce.
The Haidbach deposit in the Central Tauern Window, Eastern Alps, Austria: a metamorphosed orthomagmatic Ni-Cu-Co-PGE mineralization in the Polymetallic Ore District Venediger Nappe System – Hollersbach Complex
Authors: Melcher Frank , Schwabl Sonja , Onuk Peter , Meisel Thomas , Aiglsperger Thomas , Proenza Joaquín A.
Published: April 2021

Cu-Ni-Co-PGE mineralization occurs at Haidbachgraben in the Early Palaeozoic, Subpenninic Hollersbach Complex of the Central Tauern Window, Austria. Massive sulfide ore formed from sulfide melt segregated from silicate melt during intrusion of pyroxenite into magmatic rocks formed in an MORB-type environment. Relics of magmatic minerals include chromian spinel and polyphase sulfide droplets composed of pyrrhotite, chalcopyrite and pentlandite preserved in recrystallized pyrite. Both ore and host rocks were multiply deformed and metamorphosed, leading to hornblendite carrying the ore, enveloped by chlorite-epidote schist. Conditions of – likely Variscan – amphibolite facies metamorphism are documented by relict pargasitic cores in hornblende and actinolite-tremolite, and by ternary sulfarsenide compositions in the Co-Ni-Fe solid solution series that are the most common accessory minerals found in the sulfide ore. Pyrrhotite, pentlandite, chalcopyrite and pyrite are the major sulfide minerals. Chalcopyrite is Cd-rich and retains a high-temperature magmatic signature. High Co/Sb and moderate Se/As ratios in pyrite also point to a magmatic environment of mineralization. The accessory mineral assemblage of small grain size (mostly <10 µm) comprises native Au-Ag alloy and petzite as Au-Ag minerals, sperrylite, a variety of Pd tellurides and bismuthotellurides with elevated Sb, irarsite, and Re sulfides such as tarkianite and a Pb-Re sulfide. In addition, minor molybdenite, bournonite, scheelite and selenides have been identified. Two precious metal assemblages are present in individual samples: (1) hessite associated with Pd tellurides, often accompanied by sphalerite and chalcopyrite; (2) tarkianite forming euhedral inclusions in pyrite. Sperrylite and Au-Ag native alloys are present throughout and were also detected in silicate matrix. Most of the precious metal-bearing phases must have formed during recrystallization of base metal sulfides after the magmatic, and probably during later metamorphic events terminating in the Neoalpine Tauern crystallization.
Quality of life, health-related, and features of osteopathic treatment of patients
Authors: Matvienko Viktor V. , Buchnov Alersander D.
Published: April 2021

Evaluation of the effectiveness of osteopathic treatment of 50 women, aged 30 to 40 years, with different types of disease: psychophysiological insomnia, a syndrome of chronic venous discirculation brain, adhesive disease of the pelvic organs (operation history about 1012 years ago) due to uterine myoma and cyst one or both ovaries. With the help of a questionnaire SF-36 was assessed in the dynamics of indicators of quality of life before and after osteopathic treatment. According to the correlation and factor (principal components) analyses the peculiarities of interrelations of indicators of the osteopathic status and quality of life before and after osteopathic treatment.
High frequency radio wave method in the correction of involute skin changes
Authors: Yusova Zhanna Yu. , Akhmedbaeva Inga A. , Likhtareva Anzhelika S.
Published: April 2021

The study presents data on the impact of the monopolar radiofrequency method on the morphofunctional state of the skin. Patients were observed with various morphotypes of involute skin changes. 49 patients aged 45 to 55 years were observed. All patients were divided into 3 groups depending on the prevailing morphotype of involute skin changes: fine-wrinkled, deformed, and mixed. In all groups, a single exposure was performed using the monopolar radio frequency method according to the approved Protocol of work in the face area. Objective research methods included ultrasound sonography of the epidermis and dermis, adapted dermatological indices of quality of life (DIQ) and SAN (well-being, activity, mood). The results were evaluated 3, 6 and 12 months after the treatment. The obtained data showed that the high-frequency radio-wave method is more effective in deformational and mixed types of aging compared to small-scale wrinkling.
A new combined method for the treatment of involutional changes in the periorbital region
Authors: Khaliullin Rustam I. , Surkichin Sergey I.
Published: April 2021

Background. The solution to the problem of correction of involutional changes in the periorbital region requires a multidisciplinary approach, as this location can comprise a broad range of problems that need to be addressed. For so many years, laser therapy methods have been the standard for correcting age-related changes. However, many issues concerning combined methods remain open, and the search and development of the most effective protocols for their use is therefore an urgent task of modern medicine.
Objective. The goal of the study was to develop a combined method to correct involutional skin changes in the periorbital region in young and middle-aged patients using a fractional Nd:YAG and CO2 laser in conjunction with lower transconjunctival blepharoplasty, based on the study of clinical efficacy results and taking into account the indicators of the qualitative characteristics of the skin, as well as microcirculation.
Material and methods. The study enrolled 108 patients with involutional changes in the skin of the lower eyelid. These patients were classified into groups based on the method of treatment. In the study, relevant methods were used, namely, the study of the qualitative characteristics of the skin (cutometry, TEVA-metry, and corneometry) and microcirculatory processes using laser flowmetry.
Results. The effectiveness of the developed combined method is based on a substantial positive impact on active and passive hemodynamic mechanisms at all levels of the microvasculature, as demonstrated by an increase of 45.92% in the integral indicator of microcirculation compared to 26.35% and 5.77% in the comparison groups, while the coefficient of variation in the microcirculation indicator increased by 33.02% compared to 24.19% and 6.46% following the use of the method components. The use of the combined treatment method restores the qualitative characteristics of the skin, namely, the moisture index increased by 27% (p 0.05) compared to 14.1% and 7.8% in groups 1 and 2, respectively; the rate of transepidermal water loss decreased by 47% (p 0.05) compared to 35% and 12.7% in groups 1 and 2, respectively; and the elasticity index Ua/Uf increased by 23.2% (p 0.05) compared to 18.4% and 16.4% in groups 1 and 2, respectively.
Conclusion. Based on the study, it can be concluded that the combined treatment method developed is highly effective.
Selective ablative laser technologies in the correction of involutional skin changes
Authors: Yusova Zhanna Yu. , Baranova Elena L.
Published: April 2021

Using a combined application of surface and deep fractional ablation allows you to solve a wider range of problems in the correction of aesthetic deficiencies in the case of involute skin changes. The study examined the clinical efficacy of the interference of the superficial and deep fractional ablation on epiflourescent and ultrasonic parameters of the skin. There were 52 patients under observation, who were divided into 2 groups according to the treatment regimen. Surface fractional ablation was performed in group 1, and interference of surface and deep fractional ablation was performed in group 2. The analysis of clinical data and the degree of satisfaction with the procedures showed a more pronounced clinical effect when performing combined exposure.
Non-medical technologies in medical rehabilitation of patients with chronic pancreatitis (literature review)
Authors: Bilyukin Sergey Yu. , Makhinko Anna N. , Kaisinova Eugeniya K. , Akhkubekova Nelli K. , Dzhioeva Alla S.
Published: April 2021

The authors conducted a literature review of foreign and domestic researches on medical rehabilitation of patients with chronic pancreatitis in stationary (stage 2) and sanatorium-and-spa (stages 2 and 3) conditions. There have been presented non-medical methods of rehabilitation using natural therapeutic factors, modern instrumental physiotherapy, and therapeutic physical education.
Vasocorrigating effect of general magnetotherapy and electromyostimulation with biofeedback in combination with fractional microablative co2 laser therapy in patients with posterior vaginal wall prolapse after surgery
Authors: Lyadov K. V. , Kotenko K. V. , Zhumanova E. N.
Published: April 2021

Background. The high recurrence rate after surgical treatment of pelvic organ prolapse makes it necessary to improve therapeutic methods.
Objective: to develop and scientifically substantiate the use of a rehabilitation complex, including general magnetotherapy, electromyostimulation with biofeedback in combination with fractional microablative therapy with a CO2 laser, in patients of different age groups with rectocele after surgery.
Methods. The article presents the treatment data for 100 women of childbearing, peri- and menopausal age with rectocele IIIII degree, which were divided into 2 groups comparable in terms of clinical and functional characteristics (main and control), within each group they were divided by 2 subgroups: subgroup A included women of childbearing age, subgroup B included women of peri- and menopausal age. The patients of the main group in the early postoperative period after plastic surgery for rectocella (from 1 day) underwent a course of general magnetotherapy and in the late postoperative period (one month after the operation) they performed a set of measures consisting of a course of electromyostimulation with biological connection of the pelvic floor muscles and a special complex physiotherapy exercises and 2 intravaginal procedures of fractional microablative CO2 laser therapy with an interval of 45 weeks. Patients in the control group after surgical treatment of rectocele in the late postoperative period received symptomatic therapy, including painkillers and antispasmodics, which served as a backdrop for patients of the main group.
Results. As a result of the studies, it was found that regardless of the age and severity of uterine blood flow disorders in the uterine arteries in patients with rectocele, the most pronounced dynamics was observed in patients of the main group, which, in our opinion, is associated primarily with the vasoactive effects of general magnetotherapy, manifested in the removal of spasm from arteries and arterioles, improving the contractility of the veins and increasing venous outflow, which in combination with electrical stimulation, exercises to strengthen the muscles of the pelvis bottom and fractional microablative therapy allowed to obtain such a pronounced vasocorrigating effect.
Conclusions. Due to the pathogenetic effect of the developed complex (electrical stimulation, exercises to strengthen the pelvic floor muscles and fractional microablative therapy) on one of the main mechanisms of the development of the disease, a pronounced vasocorrecting effect was obtained.
Photodynamic therapy for correction of involutive facial skin changes
Authors: Surkichin S. I. , Bochkova N. V. , Kholupova L. S.
Published: April 2021

Background.The appearance of the skin is of high social importance, largely determining the behavior and self-confidence of a person. The relevance of methods for the correction of involutive skin changes is growing every year. One modern treatment for photodamaged skin is photodynamic therapy.
Objective:the study evaluated the effectiveness of photodynamic therapy using chlorin E6 as a photosensitizer for the correction of involutive changes in the skin of the face compared to using only light exposure.
Methods.The study involved patients aged 4060 years with signs of involutive changes in the skin of the face. In group 1 (n=36), patients underwent therapy using only light coherent radiation. In group 2 (n=35), patients underwent PDT using light coherent radiation.
Results.According to the results of elastometry, corneometry, assessment of transepidermal water loss, ultrasound examination of the skin in group2, more positive indicators were obtained than in group1. When assessing safety, the results in groups 1 and2 are comparable.
Conclusions.The method of photodynamic therapy using chlorin E6 can be recommended for course use in wide clinical practice.
A method of treating complications after contour plasty with preparations based on stabilized hyaluronic acid in the nasolacrimal sulcus region
Authors: Aksenenko I. P. , Gerasimenko M. Yu.
Published: April 2021

Background.In order to correct involutive changes in the skin or aesthetic defects, fillers based on stabilized hyaluronic acid, which are used to fill in various wrinkles and creases, have recently become most popular. It is the procedure of contouring that is one of the three most popular cosmetic procedures.
Objective:to study the effectiveness of a combined method that includes a course of longidase diadinamophoresis and injectable carboxytherapy in correcting complications of contouring the nasolacrimal sulcus area with fillers based on stabilized hyaluronic acid.
Methods.There were 29 women under observation, average age 36.4 4.4 years with complications after the introduction of a filler based on stabilized hyaluronic acid with localization in the nasolacrimal sulcus. There were 3 groups of patients who received a course of longidase diadinamophoresis (3000 IU), a course of carboxytherapy, or a combination of them.
Results.The use of a combined course of longidase diadinamophoresis (3000 IU) and carboxytherapy has a significant effect, reducing the clinical manifestations in the form of contouring and compaction, local edema and neuropathy, and stabilizing the psychoemotional state of patients. In addition, the treatment complex significantly accelerates the biodegradation of the filler and has a restructuring effect on the skin of the nasolacrimal furrow-reduces the thickness of the dermis and increases the dermis density coefficient, which is probably due to the regression of intra-dermal edema that occurs as a reaction to a superficially introduced filler based on stabilized hyaluronic acid.
Conclusion.The combined use of the method, which includes a course of longidase diadinamophoresis and injectable carboxytherapy for the correction of complications of nasolacrimal sulcus contouring with fillers based on stabilized hyaluronic acid in the form of local edema, neuropathy and filler contouring, is a highly effective treatment method, which is confirmed by the relief of clinical symptoms, acceleration of drug biodegradation and improvement of the quality of life of patients.
Influence of pulse magnitotepapy on capillary blood flow indicators in complex treatment of patients with gonarthrosis
Authors: Byalovsky Yu. Yu. , Ivanov A. V. , Zaytseva T. N. , Evstigneeva I. S.
Published: April 2021

Background.Today, osteoarthritis, in particular its clinical form of gonarthrosis, is the most common degenerative-dystrophic diseases of the joints in practice in all countries.
The objective:of the present study was to estimate the efficacy of local pulsed magnetotherapy on capillary blood flow in patients with osteoarthritis of the knee joint.
Methods.A total of 50 patients aged from 36 to 65 years with IIII stage gonarthrosis. All patients of the main group (n=25) received treatment with a pulsed magnetic field and NSAID therapy (diclofenac 25 mg 3 times a day, course 15 days). Patients in the comparison group (n=25) received only NSAIDs. The functional state of the capillary bed was assessed by biomicroscopy of the vessels of the outer corner of the eye using a fiber optic ophthalmoscope with a Riester Ri-ScopeL diode lamp (Germany). The state of the vessels of the angle of the eye was assessed by capillary (KI1) intravascular (KI2), extravascular (KI3) and general (KIgen) indices.
Results.After a course of local pulsed magnetotherapy, normalization of the ateriol-venular ratio, restoration of blood flow through the capillaries and the disappearance of a cloudy background were noted in all patients of the main group. After 6 months, the found changes were preserved in the patients of the main group, while in patients receiving NSAID mototherapy, all positive changes from the capillary blood flow disappeared.
Conclusions.In recent years, magnetotherapy, both general and local, has been successfully used to treat patients with gonarthrosis. One of the mechanisms of action of magnetic fields is to improve microcirculation in tissues. The therapeutic effect of magnetic fields in gonarthrosis has been studied, and its high efficiency has been proven.
The rationale for the use of selective pulsed electrotherapy in rehabilitation programs after surgery on the pelvic organs
Authors: Lyadov K. V. , Muravlev A. I. , Kovalev S. A.
Published: April 2021

The article presents the results of clinical and experimental research of Russian and foreign scientists on the use of modern non-drug technology-selective pulse electrotherapy for various diseases and justification of its use in rehabilitation programs after pelvic surgery.
Outbreaks of infectious diseases in healthcare facilities: Issues of epidemiological diagnostics and preanalytical stage
Authors: Smirnova Svetlana S. , Yuzhanina Tatyana S. , Vyatkina Lyudmila G. , Golubkova Alla A. , Alimov Alexander V.
Published: April 2021

Background. The issue of outbreaks of infectious diseases in healthcare facilities is not often discussed in the scientific community. Several years ago, the primary etiological agents of outbreaks in hospitals were bacteria, whereas in most cases under modern conditions, outbreak incidence is caused by viruses.
Aim. Based on the analysis of research materials on outbreaks of infectious diseases in healthcare facilities of Ural and Siberian Federal Districts, this work aimed to characterize infectious diseases under contemporary conditions and identify problematic issues of the preanalytical stage of epidemiological diagnostics and the organization of preventive and anti-epidemic measures.
Methods. The data of federal statistical monitoring form No. 23 Information on outbreaks of infectious diseases (18 units of information) and the copy of the Acts of an epidemiological investigation of foci of infectious (parasitic) diseases with the establishment of a causal relationship (14 units of information) were analyzed. The work used epidemiological and statistical methods of information processing. The significance of differences between the indices of independent samples was evaluated using Fishers exact test.
Results. In 2018, 14 outbreaks of infectious diseases were recorded in healthcare facilities in 7 out of 18 subjects in Ural and Siberian Federal Districts. The total number of victims was 183 people (97 (53.0%) children and 86 (47.0%) adults). Most of the outbreaks (12 of 14; 85.7%) were of viral etiology. One outbreak was of bacterial, and one was of fungal origin.
Discussion. Viruses played a key role in the formation of foci with multiple diseases in the healthcare facilities of Ural and Siberian Federal Districts in 2018. Most of the foci of infection with an aerogenic transmission mechanism were caused by varicella-zoster virus, and those with fecaloral transmission mechanism were etiologically associated with Norwalk virus. Children were the most vulnerable contingents in outbreaks in the healthcare facilities. In all the situations analyzed, the prerequisites for an outbreak include the untimely isolation of the source of infection, hospital overload, and inadequate financial and logistical support. Anti-epidemic measures were conducted to the fullest extent during outbreaks of acute intestinal infections in comparison with outbreaks of a different etiology.
Conclusion. Most outbreaks registered in the hospitals could be prevented by vaccination of the related population.
Detection of Coxiella burnetii in ticks collected from cattle in several provinces of the Republic of Guinea
Authors: Panferova Yulia A. , Freylikhman Olga A. , Tokarevich Nikolay K. , Naydenova Ekaterina V. , Zakharov Kirill S. , Senichkina Ayslu M. , Agafonov Dmitry A. , Nassour Abdulay A. , Konstantinov Oleg K. , Sanaba Boumbaly , Boiro Mamadou Yero
Published: April 2021

Background. Q fever, or coxiellosis, is a natural focal disease characterized by polymorphism of clinical signs and can affect not only humans but also many species of animals. This infection is spread almost all over the world. On the African continent, the foci of coxiellosis infection endanger the local population and people arriving for temporary stay. Given that sick agricultural animals and their ectoparasites are markers of the presence of infection in the region, a study of the latter may be relevant to identify the potential foci of Q fever.
This work aimed to identify Coxiella burnetii DNA from ixodic ticks collected from cattle in several provinces of Republic of Guinea and to type isolates using genetic markers (plasmid type) to enable their comparison with strains of different geographical origin.
Methods. Using amplification technologies, we investigated the ticks obtained from cattle in the provinces of Boke and Kindia to detect Coxiella DNA.
Results. The genetic material of the Q fever causative agent was detected in no more than 5% of the total number of samples studied. For positive samples, typing was performed using plasmid analysis. The isolates with the plasmid type QpH1 circulate in the Republic of Guinea.
Conclusion. The findings were analyzed along with data from other researchers on the spread of Q fever in subequatorial Africa. The differences in the levels of prevalence of Coxiella in ticks in the territories of not only different countries but also within the same state can be determined by the prevalence among the hosts within herds. The risk of contamination with Q fever in endemic regions should be considered.
THE EPIDEMIOLOGICAL SITUATION AND A TREND IN THE DRUG RESISTANCE OF MYCOBACTERIUM TUBERCULOSIS IN THE SMOLENSK REGION IN 2005-2010
Authors: Myakisheva T. V. , Gudenkov M. A.
Published: April 2021

The tuberculosis epidemiological situation in the Smolensk Region in 2005-2010 was appraised as poor and more tense than that in Russia as a whole. Its deterioration was noted in terms of most indicators in the past 6 years. The general healthcare network facilities were found to inadequately detect patients with tuberculosis particularly with fluorographic methods. There was a change in the pattern of drug resistance in Mycobacterium tuberculosis in the region, a decrease in monoresistance, an increase in multidrug resistance, and preservation high of polyresistance.
STANDARD EPIDEMIOLOGICAL CASE DEFINITION AND RISK FACTORS OF NOSOCOMIAL PNEUMONIA TERM AND PRETERM INFANTS
Authors: Sergevnin V. I , Gusmanova P. S , Khokhryakov R. V , Markovich N. I , Tokmakova O. G , Artemova O. L
Published: April 2021

Based on the results of studying the frequency of clinical and laboratory symptoms single standard epidemiological estimate of pneumonia is designed to be possible to be used with respect to full term and preterm infants. Such estimate should include the presence of inflammatory reaction in the lung on chest radiograph and at least one of the symptoms such as apnea, wheezing, sputum. For term infants the leading risk factor for nosocomial pneumonia associated with neonatal departments at Children ’s Hospital, was established to be a long-term (over 5 days) mechanical ventilation. For preterm newborns the risk factor for pneumonia, in addition, may be a history of respiratory distress syndrome, pneumopathy, intrauterine growth retardation, amniotic fluid aspiration and asphyxia at birth.
Taxonomic status of Bhanja and Kismayo viruses (family Bunyaviridae)
Authors: Klimentov A. S , Gmyl A. P , Butenko A. M , Gmyl L. V , Isaeva O. V , Larichev V. F , Khutoretskaya N. V , Karganova G. G
Published: April 2021

The nucleotide sequence of M= (1398 nucleotides and L= (6186 nucleotides) segments of the genome of Bhanja virus and L-segment (1297 nucleotides) of Kismayo virus has been partially determined. Phylogenetic analysis of deduced amino acid sequences showed that these viruses are novel members of the Flebovirus (Phlebovirus) genus in the family Bunyaviridae
THE SPECIFIC FEATURES OF CANICOLA FEVER IN THE VOLGOGRAD REGION: BIOTIC STRUCTURE, EPIZOOTIC ACTIVITY, EPIDEMIC MANIFESTATIONS
Authors: Pogasy N. I. , Alekseyev V. V. , Britanova A. L. , Smelyansky V. P. , Manankov V. V. , Tkachenko G. A. , Antonov V. A. , Putintseva E. V. , Chaika A. N. , Zlepko A. V. , Savchenko S. T. , Filippov N. V. , Sayapin A. G.
Published: April 2021

Leptospirosis was studied in the natural and anthropurgic foci in the Volgograd Region. The etiological structure of Leptospira was established in wild and farm animals. Retrospective analysis of human morbidity identified three main periods associated with the change of Leptospira serogroups that cause the disease.
Approaches of optimization the epidemiological surveillance of anthroponoses with fecal-oral mechanism of transmission
Authors: Mindlina A. Ya
Published: April 2021

A retrospective epidemiological analysis of Viral hepatitis A, shigellosis Sonne and Flexner, rotavirus infection rate in Russia for the period 2003-2009, as well as the correlation analysis of the impact of various socio-economic factors on the incidence of the above mentioned anthroponoses with fecal-oral mechanism of transmission has been performed. Marked territorial inequality in the distribution of incidence of anthroponoses with fecal-oral transmission, and a strong correlation between infections rate and characteristics of demographic indices have been revealed. The necessity of optimizing the system for epidemiological surveillance of anthroponoses with the fecal-oral mechanism of transmission, based on a comprehensive assessment of the impact of various socio-economic factors on the manifestations of disease with the use of modern mathematical methods of correlation, multivariate dispersion, and other types of analysis has been shown.
FEATURES OF AUTOROSETTE FORMATION IN PERIPHERAL BLOOD IN PATIENTS WITH HIV INFECTION
Authors: Korichkina L. N. , Vinogradova T. S. , Tofilo E. L.
Published: April 2021

In 108 HIV-infected patients studied the phenomenon of endogenous autorosette formation in peripheral blood in the peripheral blood has been studied. The total number of autorosettes and autorosettes with exocytic lysis was established to be much greater than in healthy individuals. This, along with neutrophilic and monocytic autorosettes a large number of autorosettes formed by platelets has been observed. Under the influence of antiretroviral therapy the number of platelet autorosettes decreases, the number of neutrophils and monocyte-derived autorosettes rises, eosinophilic autorosettes appear. Such dynamics seems to reflect the features of intercellular relationships in the blood of patients with HIV infection/ that indicates significant disturbances in the immune system and can serve as an indicator of treatment efficacy.
Crimean hemorrhagic fever: epidemiology, clinical picture, differential diagnosis
Authors: Ugleva S. V , Burkin A. V , Borisova I. E , Shabalina S. V
Published: April 2021

The article is devoted to the study of epidemiology, clinical features of Crimean hemorrhagic fever (CHF). A differential diagnosis with fevers, predominant in the Astrakhan region has been performed. The incidence rate for 2000-2009 according to the gender, age and occupation has been studied. The results of clinical and epidemiological examination of inpatients of the Regional Infectious Clinical Hospital of Astrakhan are presented. On the basis of the 128 cases the morbidity in 2000-2009 has been analyzed. The intensity distribution of CHF in the areas of the Astrakhan region has been investigated. At the present stage CHF occurs in moderate to severe forms with a peak incidence in June.
Distance education and advanced level training of doctors on questions of infectious pathology
Authors: Baranova I. P , Nikolskaya M. V , Lesina O. N , Konnova O. A , Krasnova L. I , Zykova O. A , Kerimova Zh. N
Published: April 2021

The aim: Introduction of advanced-level training cycles (ALTC) in the form of online mode distance education on actual questions of infectology and the evaluation of their effectiveness in the postgraduate training of doctors. Giving ALTC in the form of online mode distance education (full, partial) on the actual questions of infectology is based on phasing and systemity of ongoing project and should include five basic steps: defining the aim of the project and the participants of its implementation, delivering information resources and development of electronic versions of educational and resource materials, contractual process with the customer, Internet Service Provider and technical testing of telecommunication systems, the direct holding of distance cycle, expert evaluation of the quality of distance learning. Implementation of online mode distance learning assumes the use of modern information and telecommunication resources, interactive technologies, clear organizational and administrative decisions, professionalism of teachers, the interaction of all the participants in the educational process (including doctors pariticipants) and should be completed with the resulting expertise.
CURRENT APPROACHES IN THE TREATMENT OF DYSENTERY IN CHILDREN
Authors: Ulukhanova L. U.
Published: April 2021

The paper presents the results of studying the efficacy of immunocorrection drugs: a complex immunoglobulin preparation (CIP), kipferon and licopid in children with Flexner 2a dysentery. Analysis of the dynamics of the disappearance of symptoms of infectious toxicosis showed that after additional inclusion in complex starting therapy such immunomodulators as CIP, kipferon and licopid symptoms of toxicity disappeared faster than under alone basic therapy.
HISTORY OF THE ACTIVITY OF RUSSIA’S ANTIPLAGUE SERVICE IN THE EARLY 20TH CENTURY
Authors: Blokhina N. N.
Published: April 2021

The paper deals with the history of controlling the outbreaks occurring in 1911-1914. It gives the chain of affairs of statesmen (including principal medical inspector L. N. Malinovsky) in controlling plague. The activities of the Tsaritsyno bacteriology station (its head was medical bacteriologist A. A. Churilina) and the Chita bacteriology station (its head was medical bacteriologist I. S. Dudchenko) are analyzed.
THE CONDITION OF HUMORAL IMMUNITY IN PATIENTS WITH PNEUMONIA ASSOCIATED WITH INFLUENZA A/H1N1
Authors: Romanova E. N. , Govorin A. V. , Gorbunov V. V. , Lukyanov S. A.
Published: April 2021

The study of serum immunoglobulins in patients with severe pneumonia associated with influeunza A/H1N1 showed that the greatest increase in IgM has been noted at the onset of hospital treatment. Increasing the concentration of IgA noted equally with varying severity of influenza pneumonia, in contrast to bacterial. IgG indices recorded at the control level of numbers in all studied groups.