bluuebunny/crossref_metadata_2025 huggingface dataset:
An Online Tool for Survival Prediction of Extrapulmonary Small Cell Carcinoma with Random Forest
Authors: Zhang Xin
Published: December 2022

PurposeExtrapulmonary small cell carcinoma (EPSCC) is rare, and its knowledge is mainly extrapolated from small cell lung carcinoma. Reliable survival prediction tools are lacking.Methods7813 cases of EPSCC were collected from the Surveillance Epidemiology and End Results (SEER) database as the train and internal validation cohort of the survival prediction model. The endpoints were overall survivals of 0.5-5 years. Internal validation performances of machine learning algorithms were compared, and the best model was selected. External validation was performed to evaluate the generalization ability of the selected model.ResultsAmong machine learning algorithms, the random forest model performs best on internal validation, whose area under the curve (AUC) is 0.734-0.811. The net benefit is higher than the TNM classification in decision curve analysis. The AUC of this model on the external validation cohort is 0.779-0.823. This model was then deployed online as a free, publicly available prediction tool of EPSCC. (http://42.192.80.13:4399/).ConclusionsThis study provides a well-performed online survival prediction tool for EPSCC with machine learning and large-scale data.
Prioritizing the initial problem choice in the inventive design process: Proposal of an FMEA-AHP-based method
Authors: Hanifi Masih , Chibane Hicham , Houssin Remy , Cavallucci Denis , Abdellatif Mohamed
Published: December 2022

Today, companies are competing to improve the innovation cycle time in order to gain pioneering advantages in the market. To achieve this goal, these companies could apply the TRIZ-based systematic approaches such as Inventive the Design Methodology (IDM). Nevertheless, one of the criticisms often leveled is that these approaches are time-consuming due to the demands for building a complete map to clarify a problem situation in the initial analysis phase of the inventive design process. As a result, the Inverse Problem Graph (IPG) method has been proposed to increase the agility of the process by starting the problem formulation from an initial problem located in the lower level of a problem situation. The application of the IPG method decreases problem formulation time by identifying a limited number of problems. However, this method does not provide any tool for prioritizing the initial problems in the process. The purpose of this article is to integrate a Failure Mode Effect Analysis (FMEA) - Analytic Hierarchy Process (AHP) based method into the IPG method to prioritize the initial problems in the first phase of the design process. The proposal capability is finally tested through its application in a case study on the Lattice Structure.
Microbiome engineering optimized Antarctic microbiota to support a plant host under water deficit
Authors: Rodriguez Rodrigo , Barra Patricio , Larama Giovanni , Carrion Victor , Mora Maria de la Luz , Lauren Hale , Duran Paola
Published: December 2022

Background:Climate change challenges modern agriculture to develop alternative and eco-friendly solutions to alleviate (a)biotic stresses. The use of soil microbiomes from extreme environments opens new avenues to discover novel microorganisms and microbial functions to protect plants. In this study we confirm the ability of a bioinoculant, generated by natural engineering, to promote host development under water stress. Microbiome engineering was mediated through three factors i) Antarctic soil donation, ii) water deficit and iii) multigenerational tomato host selection.Results:We revealed that tomato plants growing in soils supplemented with Antarctic microbiota were tolerant to water deficit stress after 10 generations. Microbial community analysis using 16s rRNA amplicon sequencing data suggested that CandidatusNitrocosmicusandBacillusspp. were key taxa associated with the observed enhanced water deficit tolerance.Conclusions:We proposed that in situ microbiota engineering through the evolution of tridimensional factors (long-standing extreme climate adaption and host and stress selection) could represent a promising strategy for novel generation of microbial inoculants.
Utmost good faith principle in Indonesian insurance law as a legal reason to harm the insured party
Authors: Mulhadi Mulhadi , Harianto Dedi
Published: December 2022

The principle of utmost good faith has been recognized as one of the essential principles in insurance, and its practice in other countries has been fairly applied to both parties. It is suspected that this insurance principle in regulation and its implementation in Indonesia only burdens one unilateral. Therefore, this study aims to prove the allegation that the principle of utmost good faith favors only the insurer and its application in dispute resolution directed at harming the insured party. This study uses a case study approach, with five insurance legal cases in the form of court decisions as purposively selected objects. Qualitative analysis (content analysis) was then carried out to obtain data: data codification, data presentation, and conclusions/verification. The principle of utmost good faith is regulated by the following documents of Indonesian insurance law: Indonesian Commercial Law Code, Act No.7/1992 and Act No.40/2014. The results showed that the utmost good faith principle in several Indonesian insurance regulations is more in favor of insurance companies. The insurance company always utilizes Article 251 of the Indonesian Commercial Law Code or the utmost good faith principle as a shield to commit fraud, and refuses to fulfill its legal liability with the aim of harming the insured.
AcknowledgmentsWe thank to the Ministry of Education, Culture, Research and Technology of the Republic of Indonesia for supporting and funding this research until it was completed on time.
Incidência de internações e mortalidade por sepse em um hospital do Rio Grande do Sul - Brasil
Authors: Moreno de Camargo Diovana , Abreu Anna Paula , Glitzenhirn Meincke Alessandra , Reinke Ciechowicz Carolina , Dallazen Sartori Fernanda , Windmöller Pollyana , Roseli Winkelmann Eliane
Published: December 2022

Introdução: O tratamento para os indivíduos acometidos por sepse deve ser o mais precoce possível, pois sabe-se que o tempo de internação hospitalar nesses pacientes se torna prolongado, acarretando inúmeras limitações e, até mesmo, o risco de ir a óbito. A sepse tem se tornado de grande impacto na saúde devido ao fato de ser uma das responsáveis pelas altas taxas de mortalidade hospitalar. Objetivos: Analisar a incidência de internações e mortalidade por sepse no período de um ano em um hospital do noroeste do Estado do Rio Grande do Sul. Metodologia: Estudo transversal, analítico, retrospectivo, do tipo observacional, realizado por intermédio de coleta de dados em prontuários eletrônicos disponibilizados pelo hospital, por meio do Código Internacional de Doenças – Sepse (CID 10 – A41) –, dos pacientes internados de janeiro a dezembro de 2018. Resultados: Foram hospitalizados, no total, 112 pacientes com diagnóstico de sepse. A idade média foi de 70, 40 anos, com predomínio do sexo masculino. O tempo de internação hospitalar foi de 10 dias e na unidade de terapia intensiva de 2 dias. A utilização da ventilação mecânica invasiva e não invasiva foi de 31,3% e 8%, respectivamente. A mortalidade ocorreu em 51,8% dos casos hospitalizados com sepse, sendo a predominância na faixa etária superior aos 81 anos. Conculsões: A mortalidade foi significativa nos pacientes, demonstrando maior prevalência na faixa etária superior aos 81 anos. Pode-se, observar, também que o tempo de internação hospitalar foi elevado assim como a utilização da ventilação mecânica invasiva.
Defining the Composition of Fat Phase in Foods
Authors: Serikov Maksat , Nurgaliyeva Meruyet , Myrzabek Karima , Toishimanov Maxat , Baktybayeva Farida
Published: December 2022

Trans-fatty acids enter the human body with hydrogenated fats. The oil and fat industry must inform consumers about the fatty acid composition of food products, including the content of saturated fatty acids and trans-isomers. This study used the method of instrumental analysis to determine the fatty-acid profile and the content of trans-fatty acids in margarine. The research involved ten commercial samples of margarine. The fatty acid composition was studied by gas chromatography and mass spectrometry. The calibration graphs were based on standard mixes of methyl esters of individual fatty acids. Some oils appeared to contain ≥ 17% of palmitic acid. The total content of saturated fatty acids was 20.04–38.84%; the content of monounsaturated acids ranged from 27.92 to 36.81%, while that of polyunsaturated acids was between 14.51 and 28.99%. The margarine samples contained no butter (dairy) fat. All the samples contained 0.01–23.06% of trans-fatty acids. If the share of trans-fats exceeded 2%, it meant that the technical regulations had been violated, and hydrogenated oils had been introduced into the formulations. The highly specific mass spectrometric approach made it possible to detect trace trans-fatty acids, thus eliminating the chance of unreliable or false positive results. These methods proved to be an effective means of regulatory compliance and counterfeit prevention.
Microbial Treatment and Oxidative Stress in Agricultural Plants
Authors: Milentyeva Irina , Fotina Natalya , Zharko Maria , Proskuryakova Larisa
Published: December 2022

Anthropogenic factors expose agricultural plants to abiotic and biotic stresses, one of which is oxidative stress. Oxidative stress changes cell metabolism, as well as inhibits plant growth and development. Microbial treatment is an environmentally safe method of oxidative stress prevention. The research objective was to study the antioxidant activity of microflora native to coal dumps in order to combat the oxidative stress in crops.

The study featured microorganisms isolated from technogenically disturbed soils. Pure bacterial cultures were isolated by deep inoculation on beef-extract agar. A set of experiments made it possible to define the cultural, morphological, and biochemical properties of cell walls. The antioxidant activity and the amount of indole-3-acetic acid were determined on a spectrophotometer using the ABTS reagent and the Salkowski reagent, respectively. The isolated microorganisms were identified on a Vitek 2 Compact device. The biocompatibility of strains was tested by dripping, while the increase in biomass was measured using a spectrophotometer.

The study revealed ten microbial strains with antioxidant activity ranging from 67.21 ± 3.08 to 91.05 ± 4.17%. The amount of indole-3-acetic acid varied from 8.91 ± 0.32 to 15.24 ± 0.69 mg/mL. The list of microorganisms included Klebsiella oxytoca, Enterobacter aerogenes, Pseudomonas putida, and Bacillus megaterium. The consortium of P. putida and E. aerogenes demonstrated the best results in antioxidant activity, indole-3-acetic acid, and biomass. Its ratio was 2:1 (94.53 ± 4.28%; 15.23 ± 0.56 mg/mL), while the optical density was 0.51 ± 0.02. Extra 2% glycine increased the antioxidant activity by 2.34%, compared to the control. Extra 0.5% L-tryptophan increased the amount of indole-3-acetic acid by 3.12 mg/mL and the antioxidant activity by 2.88%.

The research proved the antioxidant activity of strains isolated from microflora native to coal dumps. The consortium of P. putida and E. aerogenes (2:1) demonstrated the best results. Further research will define its ability to reduce oxidative stress in plants.
Evaluation of Methods for Obtaining Rendered Animal Fats
Authors: Vechtomova Elena , Kozlova Oksana , Orlova Maria
Published: December 2022

The increase of functional food production makes the search for new non-traditional raw materials and the selection of methods for their processing relevant. Methods for obtaining biologically active substances of a lipid nature from valuable raw materials extracted from hunting animals (bear, badger, marmot and beaver) are of particular interest. The purpose of this review is to analyze the existing methods of obtaining rendered fat from raw fat and evaluate them.

The objects of analysis were the data of scientific articles, patents and studies on the extraction of the lipid fraction from raw materials of animal origin from 2017 to 2021. In the work, various methods for extracting fats were considered. Their systematization, analyze, and description were carried out, indicating the advantages and disadvantages.

The considered methods for extracting lipid components can be used in the process of rendering fat from non-traditional raw materials of animal origin. When using the dry rendering method, the heating of adipose tissue is carried out by the conductive method, which leads to oxidative processes and a decrease in the quality of the finished product. The wet rendering method is carried out by interacting raw fat with a heating agent – water or live steam, which, by varying the temperature and duration of exposure, allows to preserve the properties and quality of the product.

Wet rendering methods are the most effective. These methods allow to obtain a high-quality finished product, as well as to produce the maximum yield of valuable lipid components of raw materials. To accelerate the technological process with the wet method of exposure, it is possible to use a biocatalytic method. The results of the research can be used in the development of schemes for obtaining biologically active substances of a lipid nature from valuable expensive raw materials extracted from hunting animals.
Multivariate methods in modelling the removal of nitrogen and phosphorus in deep-bed two-media down-flow sand filters
Authors: Jonsson Lena Margareta , Björlenius Berndt
Published: December 2022

Multiple linear regression (MLR) was applied to study the operation and efficiency of simultaneous denitrification with sodium acetate (NaAc) as a carbon and energy source and the chemical precipitation of phosphate with iron salts in a pilot sand filter. Different loads were simulated with the addition of primary settled wastewater (PW) containing suspended solids (SS) and biological SS from the aeration tank. SS from PW partly passed the filter. Biological SS was caught by the filter. The validation of the model showed that phosphorus concentration and chemical oxygen demand reduction were easier to predict correctly than the time of operation of the filter. The reduction of total phosphorus differed between 0.01 and 0.31 mg P/L, and the nitrate concentration in the filtrate differed between 0 and 5.2 mg N/L when comparing the experimental values with the model. Experiments showed filtrate concentrations of 0–0.12 mg PO4-P/L, 3.0–8.8 mg NO3-N/L, and 1.9–34 mg SS/L. The addition of NaAc gave a small increase in the reduction of PO4-P probably because of the assimilation of PO4-P into the denitrifying sludge. The dosage of Fe gave a small decrease in the reduction of NO3-N probably because of PO4-P limitation for denitrifying bacteria, as Fe acts as a precipitation agent upon PO4-P.
ON MODELS AND METHODS OF PROBABILISTIC ANALYSIS OF INFORMATION SECURITY IN STANDARDIZED PROCESSES OF SYSTEM ENGINEERING
Authors:   Federal Research Center “Computer Science and Control” of the Russian Academy of Sciences, Kostogryzov Andrey
Published: December 2022

Purpose: rational and description of the methodological apparatus of system engineering in terms of risk prediction, taking into account the requirements for information protection. Research methods include: methods of probability theory, risk-oriented models for predictive analysis of standardized processes of system engineering. Result: interrelated models and methods systematized for use in the planning and implementation of standardized processes of system engineering are described. Their use makes it possible to analyze the impact of information security in terms of predicted risks. Methods and models are implemented in a set of system engineering standards and analytically support the effective implementation of agreement, organizational project- enabling, technical management and technical processes according to GOST R 57193 (ISO/IEC/IEEE 15288) in relation to systems for various purposes (a total of 30 processes). The proposed models and methods of system analysis of information security in standardized processes of system engineering develop established approaches to risk prediction, ensuring and improving system security. The use of the proposed models and methods in the life cycle of systems helps to identify «bottlenecks», rational ways to reduce risks in the implemented standardized processes, taking into account the requirements for information protection, supports the making decisions in analytical problems of system engineering. Scientific novelty: the proposed methodological apparatus develops the existing approaches to risk prediction, ensuring and improving systems security. The ideas are implemented in the national standards GOST R 59329 – GOST R 59357. They allow enterprises to move to the pragmatic implementation of a risk-based approach using the analytical capabilities of solving inverse problems of effective security control, based on the specified level of acceptable risk.
NEURAL NETWORK METHODS FOR RECOGNIZING SPEECH EMOTIONS TO COUNTER FRAUD IN TELECOMMUNICATION SYSTEMS
Authors:   Ivanovo Chemical-Technological University, Filimonov Andrey , Osipov Aleksey ,   Financial University under the Government of the Russian Federation, Pleshakova Ekaterina ,   Financial University under the Government of the Russian Federation, Gataullin Sergey ,   Financial University under the Government of the Russian Federation
Published: December 2022

The purpose of the article is to develop a method for detecting fraud in telecommunication systems based on the analysis of the content of a telephone conversation, based on the use of neural network methods for recognizing speech emotions. Research methods: analysis of the frequency characteristics of text representations of conversations with scammers and the dynamics of their change, analysis of the occurrence of keywords. Result: a new approach to detecting fraud in telecommunications systems based on the analysis of the emotional and semantic components of dialogues with fraudsters using neural networks and association rules is proposed. A generalized scheme of the method for detecting signs of fraud in telephone conversations is described. A scalable approach to identifying suspicious phrases based on the Apriori association rule search algorithm is proposed. A multicomponent neural network with a differentiated architecture has been created. A study was conducted on how the emotional component of dialogues with scammers changes in dynamics, in order to identify typical patterns of emotional pressure. A software prototype has been created that allows you to assess the presence / absence of emotional pressure in a conversation with scammers and assess whether the conversation is suspicious or not. The accuracy of the proposed method for detecting telephone fraudsters was evaluated. Scientific novelty: a new natural language processing technology based on artificial intelligence methods is proposed.
Avaliação da trajetória institucional do Programa Ciência Sem Fronteiras na Universidade Federal do Ceará
Authors: Garcia Márcia Monalisa de Morais Sousa , Gussi Alcides Fernando
Published: December 2022

Este artigo tem como objetivo avaliar a trajetória institucional do Programa Ciência sem Fronteiras (CsF) na Universidade Federal do Ceará (UFC), buscando compreender a percepção dos gestores sobre o Programa a partir de uma perspectiva hermenêutica de análise de políticas públicas, proposta por Lejano (2012). Nessa pesquisa, de abordagem qualitativa, foram realizadas entrevistas semiestruturadas com reitores, pró-reitores de graduação, coordenador de assuntos internacionais e coordenadores de nove cursos de graduação da Universidade, contemplando o período de implementação do Programa. Como resultados, encontramos distintas interpretações acerca do CsF e sua relação com a internacionalização da UFC, o que possibilitou uma compreensão mais ampla acerca do Programa na UFC, considerando os distintos sujeitos envolvidos em sua implementação, permitindo produzir indicadores de avaliação sobre o Programa e internacionalização, que contribuem para a afirmação da educação superior como um direito e um bem público em meio a tensões político-institucionais que a qualificam como mercadoria.
A implementação da Política Cultural e Educacional Alemã para o Exterior
Authors: Junior Paulo de Carvalho , Carvalho Cynthia Paes de , Schippling Anne
Published: December 2022

O artigo tem por objetivo apresentar as especificidades do contexto latino-americano quanto à implementação da Política Cultural e Educacional da Alemanha para o Exterior, através de uma análise das Escolas Alemãs no Exterior, localizadas nessa região. Através de uma abordagem qualitativa, ele explora os dados constantes no Diretório de Escolas no Exterior produzido pela Agência Central para Escolas no Exterior e a representação da direção escolar disponibilizadas nos sítios eletrônicos oficiais dessas escolas, analisando-os à luz de conceitos sobre implementação de políticas públicas. O artigo propõe que o sistema escolar alemão no exterior, baseado em modelos de cooperação entre instâncias governamentais alemãs e entidades privadas nos países anfitriões, se caracteriza pelo papel central de atores locais na implementação dessa política. Ele conclui que as marcas de ambiguidade da Política Cultural e Educacional da Alemanha para o Exterior possibilitam que o sistema se adapte às diferentes realidades locais das escolas.
(não) implementação de Escolas Charter em Goiás
Authors: Nazareth Henrique Dias Gomes de
Published: December 2022

O presente texto é fruto de uma pesquisa de doutorado que analisou o Programa de Contratos de Gestão com Organizações Sociais na educação básica de Goiás. Desenvolveu-se, por meio de uma pesquisa qualitativa com análise documental, tendo como fontes editais, minutas de contratos, ações do ministério público, reportagens e entrevista concedidas aos veículos de comunicação. O principal objetivo aqui é entender a tentativa de implementação do programa, descrevendo suas nuances e analisando seus desdobramentos. Ao discutir sobre as lições que podem ser extraídas a partir do caso acredita-se que a análise do programa e seu desfecho pode contribuir com pesquisadores interessados em compreender e resistir aos avanços de movimentos privatizantes na educação pública brasileira. Em suma, o artigo é sobre um programa que não foi efetivamente implementado, mas que, a despeito disso, apresenta consequências e desdobramentos para o avanço de políticas privatizantes identificadas com as charter schools no contexto brasileiro.
Política de educação em gênero e diversidade sexual
Authors: Bortolini Alexandre , Vianna Cláudia Pereira
Published: December 2022

Este artigo apresenta parte dos resultados de uma pesquisa de doutorado dedicada a analisar o ciclo de desenvolvimento da política educacional em gênero e diversidade sexual no Brasil. A partir das proposições de Stephen Ball, que acionam noções foucaultianas de poder e discurso para a análise de políticas educacionais, buscou-se, para além da métrica, compreender as dinâmicas político-discursivas que marcaram tanto a produção dessa política quanto a sistemática reação que se lançou sobre ela. Neste artigo, são apresentados seus antecedentes, suas principais ações, os agentes envolvidos na sua construção e o discurso pedagógico que produziram. São identificados também seus principais opositores, suas táticas de ação e estratégias discursivas, apontando como se articularam com os movimentos reacionários que marcaram o país nos últimos anos. Por fim, apontam-se indícios de que o debate sobre gênero e diversidade sexual nas escolas sobrevive mesmo em tempos de conservadorismo, censura e terrorismo ideológico.
banquinho ao caderninho
Authors: Oliveira Ryna Wanzeler de , Prado Ana Pires do , Rosistolato Rodrigo
Published: December 2022

O artigo analisa os procedimentos de matrícula de escolas municipais do Rio de Janeiro. Partimos da ideia de que os gestores da Coordenadoria Regional de Educação (CRE) e das escolas são os burocratas responsáveis pela implementação da política de matrícula e podem agir de forma discricionária no atendimento ao público. Consideramos que suas percepções sobre as escolas, estudantes e famílias estão pautadas em estigmas. Utilizamos entrevistas realizadas com a assessoria da CRE e com diretores de escolas da mesma região da cidade. Os resultados evidenciam discricionariedade da burocracia nos procedimentos de matrícula e revelam a produção e reprodução de estigmas das escolas, reforçando um cenário de desigualdade educacional e com tendência à iniquidade na distribuição de vagas.
Burocracia de Médio Escalão e avaliação educacional
Authors: Bravo Maria Helena de Aguiar , Alavarse Ocimar Munhoz
Published: December 2022

O objetivo deste trabalho é compreender como Burocratas de Médio Escalão cearenses se inserem na relação entre políticas públicas educacionais nacionais e cearenses, com foco no Sistema Permanente de Avaliação da Educação Básica do Ceará (Spaece), no Sistema de Avaliação da Educação Básica (Saeb) e no Exame Nacional do Ensino Médio (Enem). Observou-se que a organização da Secretaria de Educação cearense tem estrutura “semi-horizontal”, permitindo autonomia dos profissionais e afetando positivamente a qualidade técnica das ações desenvolvidas. As avaliações estão presentes nas ações estatais e nas escolas, consolidando-se por meio da coleta de dados realizada diretamente pelo Estado e pela criação da Coordenadoria de Avaliação e Acompanhamento da Educação (Coave). Observa-se cuidado da gestão estadual com a garantia do princípio de equidade entre os alunos da rede cearense. Na visão dos entrevistados, é impossível que governos subnacionais não estabeleçam relações com o governo federal na implementação de políticas educacionais.
The Ronaldo Wasum Cactarium at the Botanical Garden of Joinville Region University, Santa Catarina, Brazil
Authors: Esemann-Quadros Karin , Hering-Rinnert Cynthia , Bilk Karin Dalila , Yamamoto Manuella Aparecida Cosmo Galan , Porfirio Rodrigues Larissa , Bergmann Carina
Published: December 2022

The Ronaldo Wasum Cactarium (RWC), at the Botanical Garden (BG) of Univille, Santa Catarina, was created on April 19, 2016. Its name is in honor of Professor Ronaldo Adelfo Wasum (in memoriam), ex Director of the BG of Caxias do Sul, Rio Grande do Sul State. One of the objectives of the RWC is the ex situ conservation of cactus and other succulents species, including rare and endangered ones. In the RWC collection, there are 86 species, four of Apocynaceae, 68 of Cactaceae and 14 of Euphorbiaceae, one endemic to Santa Catarina and 17 to Brazil. 63 species are threatened with extinction: one critically endangered, three endangered, six vulnerable, three near threatened, 48 of least concern and four are data deficient. The RWC is open to the community; visits are monitored by the BG team, the Trails Program and the Visit Program of Univille. Along with the other collections of live plants at the JB and the Herbarium Joinvillea (JOI), the CRW is an important source for scientific research, in addition to providing knowledge about plants and moments of contemplation of nature to visitors. This work aims to present the CRW collection, opening up possibilities for research and interaction with other institutions and professionals who work with these species.
REFLEXÕES SOBRE DESIGN PARA O COMPORTAMENTO SUSTENTÁVEL: USO DA FIBRA DE BANANEIRA (MUSA SP) COMO RESÍDUO AGRÍCOLA RENOVÁVEL
Authors: Mariany Costa Carvalho  , Denilson Moreira Santos  , Rosemary do Bom Conselho Sales
Published: December 2022

O design de produto encontra-se diante dos desafios contemporâneos relacionados à oferta de matéria-prima e aos aspectos sociais, culturais e econômicos que norteiam o consumo e as relações entre o ser humano e o ecossistema. Nesse contexto, destaca-se o uso de materiais naturais, em especial a fibra de bananeira, para desenvolver produtos alinhados à sustentabilidade. Este estudo, de caráter qualitativo, teve o intuito de conhecer a origem do resíduo da bananeira e suas possíveis aplicações em produtos. Recorreu-se à pesquisa bibliográfica por meio de um levantamento de trabalhos na temática do design, com foco no comportamento sustentável e aplicação em produtos. Observou-se, nos estudos, que o material contribui para o aperfeiçoamento de propriedades mecânicas de certos polímeros, formando compósitos com potencial de aplicação em diversos setores.
Determination of Serum Differential Carnitine Ester Levels in HIV(+)
Patients: A Cross-Sectional Study
Authors: Binici Irfan , Akbay Halil İbrahim , Huyut Zübeyir , Alp Hamit Hakan , Karsen Hasan , Koyuncu Ismail , Gonel Ataman , Akmeşe Şükrü , Çelik Hakim
Published: December 2022

Objective:

It has been reported that carnitine deficiency is observed in various viral
infections and in the follow-up of the prognosis of some diseases. In this cross-sectional study, we
aimed to determine how carnitine ester derivatives change in HIV-positive patients.

Material and Method:

In this study, 25 HIV-infected patients who applied to Harran University
Faculty of Medicine Education Research and Practice Hospital Infectious Diseases and Clinical
Microbiology Outpatient Clinic and who did not receive any antiretroviral treatment, as well as 25
healthy volunteers were included in the study. Carnitine ester levels in serum samples were
measured by Liquid Chromatography-Mass Spectrometry/Mass Spectrometry (LC-MS/MS) method
(Shimadzu North America, Columbia, MD, USA).

Results:

While suberoylcarnitine (C8DC), myristoleylcarnitine (C14:1), tetradecadienoylcarnitine
(C14:2), palmitoleylcarnitine (C16:1), and linoleylcarnitine (C18:2) levels in HIV(+) patients were
quite low compared to the control group, tiglylcarnitine (C5:1) levels were high (p ≤ 0.05). In
addition, C5:1 and C14:2 index parameters according to VIP score, and C5:1 and C14:1/C16 index
parameters according to ROC analysis were determined as markers with high potential to
distinguish HIV(+) patients from healthy volunteers.

Conclusion:

This study showed that levels of acylcarnitine derivatives might be altered in HIV(+)
patients, and the results obtained may contribute to a better understanding of carnitine metabolism.
New Niflumic Acid Derivatives as EGFR Inhibitors: Design, Synthesis,
In silico Studies, and Anti-proliferative Assessment
Authors: Yaseen Yahya S. , Mahmood Ammar A.R. , Abbas Ali H. , Shihab Wurood A. , Tahtamouni Lubna H.
Published: December 2022

Background:

1,3,4-oxadizole and pyrazole derivatives are very important scaffolds for
medicinal chemistry. A literature survey revealed that they possess a wide spectrum of biological
activities including anti-inflammatory and antitumor effects.

Objectives:

To describe the synthesis and evaluation of two classes of new niflumic acid (NF) derivatives,
the 1,3,4-oxadizole derivatives (compounds 3 and (4A-E) and pyrazole derivatives (compounds
5 and 6), as EGFR tyrosine kinase inhibitors in silico and in vitro.

Methods:

The designed compounds were synthesized using conventional organic synthesis methods.
The antitumor activities of the new NF derivatives against HepG2 hepatocellular carcinoma and
A549 non-small cell lung cancer cell lines were assessed in vitro via MTT assay, flow cytometry,
RT-PCR, as well as via molecular docking studies.

Results:

The cytotoxicity results indicated that the newly synthesized NF derivatives were cytotoxic
against the two cancer cell lines, with compound 6 being the most cytotoxic, achieving the lowest
IC50 concentration. Furthermore, compound 6 targeted EGFR tyrosine kinase leading to cell cycle
arrest at the G2/M cell cycle phase and induction of apoptosis. The in vitro biological investigation
results matched those of the molecular docking analysis. In conclusion, the new NF derivatives, specifically
compound 6, exhibited favorable pharmacokinetic features and are promising EGFR tyrosine
kinase inhibitors.

Conclusion:

A series of niflumic acid derivatives (3, 4A-E, 5, and 6) were successfully created, and
FT-IR, 1H, 13CNMR, and HRMS were used to confirm their chemical structures. According to molecular
docking studies, compounds 3, 5, and 6 have the highest docking scores (ΔG), and most tested
compounds have a good pharmacokinetic profile. Results of compound 6 in vitro antitumor activities
showed that it is a promising EGFR tyrosine kinase inhibitor.
A Novel Perspective on Tissue Engineering Potentials of Periodontal Ligament Stem Cells
Authors: Radmand Faraz , Baseri Milad , Farsadbakhsh Maryam , Azimi Ayub , Dizaj Solmaz Maleki , Sharifi Simin
Published: December 2022

It is challenging to completely and predictably regenerate the missing periodontal tissues caused by the trauma or disease. To regenerate the periodontium, there is a need to consider several aspects that co-occur with periodontal development. This study provides an overview of the most up-to-date investigations on the characteristics and immunomodulatory features of Periodontal Ligament Stem Cells (PDLSCs) and the recent interventions performed using these cells, focusing on cell survival, proliferation, and differentiation. Keeping in mind the relationship between age and potency of PDLSCs, this work also demonstrates the necessity of establishing dental-derived stem cell banks for tissue regeneration applications. The data were collected from Pubmed and Google Scholar databases with the keywords of periodontal ligament stem cells, tissue engineering, characteristics, and stem cell therapy. The results showed the presence of wide-ranging research reports supporting the usability of PDLSCs for periodontal reconstruction. However, a better understanding of self-restoration for adequate regulation of adult stem cell growth is needed for various applied purposes.
Effect of Utilizing Health Belief Model on Knowledge, Beliefs and Behaviour of Visually Impaired Women toward Breast Self-Examination
Authors: Elsawy Manal Mohamed , Mohamed Helalia Shalabi , Mousa Khadraa Mohamed
Published: December 2022

Background

Breast self-examination is the most important behaviour for early breast cancer detection.

Aim

The aim of the study was to measure the effectiveness of utilizing a health belief model on knowledge, beliefs, and behaviour of visually impaired women toward breast self-examination. A quasi-experimental design (pre/posttest) was utilized in the current study.

Setting

At Al Nour Wal Amal Association for visually impaired women in Cairo governorate, Egypt. A purposive sample of 42 visually impaired women was included in the study. Three tools were used for the purpose of data collection  (I): Structured interviewing knowledge questionnaire;  (II): breast self-examination checklist; and  (III): health beliefs assessment scale.

Results

The findings revealed a highly statistically significant difference in visually impaired women's total knowledge, total practice, and total health beliefs scores for breast self-examination before and after the program. The women's total knowledge, behaviors, and beliefs improved in the posttest compared to the pretest.

Conclusion

The study results concluded that there was an improvement in knowledge, practice, and health beliefs regarding breast self-examination among visually impaired women after program implementation, which emphasized that educational program based on health beliefs model have a significant positive effect in improving women’s knowledge, practice, and health beliefs toward breast self-examination. It is recommended to establish educational programs to raise awareness about breast cancer and breast self-examination among visually impaired women through special schools and community associations. Community health nurses play a crucial role in educating women about breast self-examination and they are in a unique position to raise breast cancer awareness, especially among at-risk groups.
Associated Factors with Adherence Level of Elderly Patients with Hypertension to the Prescribed Medication
Authors: Theofilou Paraskevi
Published: December 2022

Background:

More and more studies have emphasized the level of adherence among patients with hypertension during the last decades.

Objective:

The purpose of this study is to investigate the level of adherence of elderly patients with hypertension to the medication given to them.

Methods:

For this purpose, a quantitative synchronous study was performed on a sample of 73 elderly patients with hypertension. The Self-Efficacy For Appropriate Medication Use Scale [SEAMS] was used to evaluate medication adherence.

Results:

The findings of the study showed that elderly patients with hypertension show a moderate level of adherence to the medication. Age, years of starting treatment, and years of diagnosis were significantly associated with the level of medication adherence in elderly patients with hypertension.

Conclusion:

More studies are needed to highlight the factors that affect the level of adherence to the medication of elderly patients with hypertension.