bluuebunny/crossref_metadata_2025 huggingface dataset:
A Predesign Methodology for Power Electronics Based on Optimization and Continuous Models: Application to an Interleaved Buck Converter
Authors: Delhommais Mylène , Delaforge Timothé , Schanen Jean-Luc , Wurtz Frédéric , Rigaud Cécile
Published: August 2022

This paper proposes an approach dedicated to power electronics preliminary design. It consists in setting the optimization problem in an “imaginary” world by considering all decision variables to be continuous. The method is illustrated in detail with the real case study of an Interleaved Buck Converter. The models used are briefly described, and the focus is also placed on all possible applications of such a quick design methodology: considering several operating points, checking various candidate technologies and negotiating the specifications of the converter with the partners.
Rapid SARS-CoV-2 Detection Using the Lucira™ Check It COVID-19 Test Kit
Authors: Zahavi Maya , Rohana Hanan , Azrad Maya , Shinberg Bracha , Peretz Avi
Published: August 2022

The need for the early identification of SARS-CoV-2 has let to a quest for reliable tests that meet the standards of polymerase chain reaction (PCR) tests, on the one hand, and are low-cost, easy-to-use, and fast, on the other hand. One such test is the Lucira™ Check It COVID-19 Test kit (“Lucira”) (Lucira Health, Inc., Emeryville, CA, USA), which utilizes real-time loop-mediated isothermal amplification technology, developed for at-home use. This study evaluated the clinical sensitivity and specificity of Lucira in identifying the virus in 190 nasopharyngeal samples collected between January and October 2021. Each sample was also subjected to RT-PCR. All negative RT-PCR results were paralleled by a negative Lucira result. Out of 90 participants who had a positive RT-PCR result, 82 (91.1%) tested positive by Lucira. Among the 72 symptomatic participants, 67 (93%) tested positive by Lucira. All samples with a positive RT-PCR result with a threshold cycle (Ct) > 36, yielded a negative Lucira result. In addition, a significant positive correlation was found between Ct and time-to-positivity with Lucira (R = 0.8612, p < 0.0001). The implementation of such a portable and affordable assay may aid in breaking the COVID-19 transmission chain.
COVID-19 Diagnosis and Classification Using Radiological Imaging and Deep Learning Techniques: A Comparative Study
Authors: Laddha Saloni , Mnasri Sami , Alghamdi Mansoor , Kumar Vijay , Kaur Manjit , Alrashidi Malek , Almuhaimeed Abdullah , Alshehri Ali , Alrowaily Majed Abdullah , Alkhazi Ibrahim
Published: August 2022

In December 2019, the novel coronavirus disease 2019 (COVID-19) appeared. Being highly contagious and with no effective treatment available, the only solution was to detect and isolate infected patients to further break the chain of infection. The shortage of test kits and other drawbacks of lab tests motivated researchers to build an automated diagnosis system using chest X-rays and CT scanning. The reviewed works in this study use AI coupled with the radiological image processing of raw chest X-rays and CT images to train various CNN models. They use transfer learning and numerous types of binary and multi-class classifications. The models are trained and validated on several datasets, the attributes of which are also discussed. The obtained results of various algorithms are later compared using performance metrics such as accuracy, F1 score, and AUC. Major challenges faced in this research domain are the limited availability of COVID image data and the high accuracy of the prediction of the severity of patients using deep learning compared to well-known methods of COVID-19 detection such as PCR tests. These automated detection systems using CXR technology are reliable enough to help radiologists in the initial screening and in the immediate diagnosis of infected individuals. They are preferred because of their low cost, availability, and fast results.
Identification of Asbestos Slates in Buildings Based on Faster Region-Based Convolutional Neural Network (Faster R-CNN) and Drone-Based Aerial Imagery
Authors: Seo Dong-Min , Woo Hyun-Jung , Kim Min-Seok , Hong Won-Hwa , Kim In-Ho , Baek Seung-Chan
Published: August 2022

Asbestos is a class 1 carcinogen, and it has become clear that it harms the human body. Its use has been banned in many countries, and now the investigation and removal of installed asbestos has become a very important social issue. Accordingly, many social costs are expected to occur, and an efficient asbestos investigation method is required. So far, the examination of asbestos slates was performed through visual inspection. With recent advances in deep learning technology, it is possible to distinguish objects by discovering patterns in numerous training data. In this study, we propose the use of drone images and a faster region-based convolutional neural network (Faster R-CNN) to identify asbestos slates in target sites. Furthermore, the locations of detected asbestos slates were estimated using orthoimages and compiled cadastral maps. A total of 91 asbestos slates were detected in the target sites, and 91 locations were estimated from a total of 45 addresses. To verify the estimated locations, an on-site survey was conducted, and the location estimation method obtained an accuracy of 98.9%. The study findings indicate that the proposed method could be a useful research method for identifying asbestos slate roofs.
An Enhanced Belief Propagation Flipping Decoder for Polar Codes with Stepping Strategy
Authors: Zhang Xiaojun , Liu Yimeng , Chen Chengguan , Guo Hua , Zeng Qingtian
Published: August 2022

The Belief Propagation (BP) algorithm has the advantages of high-speed decoding and low latency. To improve the block error rate (BLER) performance of the BP-based algorithm, the BP flipping algorithm was proposed. However, the BP flipping algorithm attempts numerous useless flippings for improving the BLER performance. To reduce the number of decoding attempts needed without any loss of BLER performance, in this paper a metric is presented to evaluate the likelihood that the bits would correct the BP flipping decoding. Based on this, a BP-Step-Flipping (BPSF) algorithm is proposed which only traces the unreliable bits in the flip set (FS) to flip and skips over the reliable ones. In addition, a threshold β is applied when the magnitude of the log–likelihood ratio (LLR) is small, and an enhanced BPSF (EBPSF) algorithm is presented to lower the BLER. With the same FS, the proposed algorithm can reduce the average number of iterations efficiently. Numerical results show the average number of iterations for EBPSF-1 decreases by 77.5% when N = 256, compared with the BP bit-flip-1 (BPF-1) algorithm at Eb/N0 = 1.5 dB.
Thermodynamic Analysis of the Possibility of Using Biomass as a Component of High-Energy Materials
Authors: Biegańska Jolanta , Barański Krzysztof
Published: August 2022

One of the unconventional, innovative ways of using biomass is using it as a component of high-energy material. According to conceptual assumptions, biomass can act as an energy carrier in modified high-energy materials-explosives (EX). Modification of the composition of the explosive requires the development of a method of introducing an additional component and changes its explosive and operational parameters (including safety). Thermodynamic calculation programs allow you to model the predicted energetic parameters of an explosive in order to select prospective compositions without the need to carry out a large number of costly and time-consuming field tests. This enables more effective design of new explosives compositions by narrowing down the scope of field tests using the “in situ” method. The use of renewable biomass as a corrector of EX properties may be a pro-environmental approach and reduces the production costs of the product. The thermodynamic simulations performed showed that, in the case of an appropriate proportion of ingredients, comparable and better energy properties were obtained in relation to the base composition. Moreover, the qualitative analysis of the sub-detonation products did not reveal the emission of additional gaseous components harmful to the environment compared to the reference explosive.
Peptide Materials in Dye Sensitized Solar Cells
Authors: Gatto Emanuela , Lettieri Raffaella , Vesce Luigi , Venanzi Mariano
Published: August 2022

In September 2015, the ONU approved the Global Agenda for Sustainable Development, by which all countries of the world are mobilized to adopt a set of goals to be achieved by 2030. Within these goals, the aim of having a responsible production and consumption, as well as taking climate action, made is necessary to design new eco-friendly materials. Another important UN goal is the possibility for all the countries in the world to access affordable energy. The most promising and renewable energy source is solar energy. Current solar cells use non-biodegradable substrates, which generally contribute to environmental pollution at the end of their life cycles. Therefore, the production of green and biodegradable electronic devices is a great challenge, prompted by the need to find sustainable alternatives to the current materials, particularly in the field of dye-sensitized solar cells. Within the green alternatives, biopolymers extracted from biomass, such as polysaccharides and proteins, represent the most promising materials in view of a circular economy perspective. In particular, peptides, due to their stability, good self-assembly properties, and ease of functionalization, may be good candidates for the creation of dye sensitized solar cell (DSSC) technology. This work shows an overview of the use of peptides in DSSC. Peptides, due to their unique self-assembling properties, have been used both as dyes (mimicking natural photosynthesis) and as templating materials for TiO2 morphology. We are just at the beginning of the exploitation of these promising biomolecules, and a great deal of work remains to be done.
Evolution and Prospects in Managing Sewage Sludge Resulting from Municipal Wastewater Purification
Authors: Di Giacomo Gabriele , Romano Pietro
Published: August 2022

Municipal sewage sludge is the residual material produced as a waste of municipal wastewater purification. It is a sophisticated multi-component material, hard to handle. For many years, it has been landfilled, incinerated, and widely used in agriculture practice. When unproperly discharged, it is very polluting and unhealthy. The rapidly increasing global amount of municipal sewage sludge produced annually depends on urbanization, degree of development, and lifestyle. Some diffused traditional practices were banned or became economically unfeasible or unacceptable by the communities. In contrast, it has been established that MSS contains valuable resources, which can be utilized as energy and fertilizer. The objective of the review was to prove that resource recovery is beneficially affordable using modern approaches and proper technologies and to estimate the required resources and time. The open sources of information were deeply mined, critically examined, and selected to derive the necessary information regarding each network segment, from the source to the final point, where the municipal sewage sludge is produced and disposed of. We found that developed and some developing countries are involved with ambitious and costly plans for remediation, the modernization of regulations, collecting and purification systems, and beneficial waste management using a modern approach. We also found that the activated sludge process is the leading technology for wastewater purification, and anaerobic digestion is the leading technology for downstream waste. However, biological technologies appear inadequate and hydrothermal carbonization, already applicable at full scale, is the best candidate for playing a significant role in managing municipal sewage sludge produced by big towns and small villages.
Thermal Effect in Nonlinear One-Dimensional Consolidation of Cold Region Soil
Authors: Wang Zongqin , Wu Wenbing , Zhang Peng , Wang Zuodong , Xi Ruichen , Wen Minjie
Published: August 2022

The thermal effect can significantly influence the consolidation of the soil, especially in the cold region. Previous studies have established to research that the drops in the ambient temperature would slow down the consolidation process, resulting in the slow dissipation of excess pore water pressure. In addition, the previous studies neglect the final settlement because consolidation is also influenced by thermal effect. In this paper, a closed-form solution to the one-dimensional nonlinear consolidation of soil considering the thermal effect is proposed. In the mathematical framework, the influences of the thermal effect on the compression index, the permeability, and the elastic modulus of the soil are considered. The solution is fully verified by comparing it with the FDM solution neglecting the thermal effect and the classic Terzaghi’s solution. An analysis has been carried out to assess the influence of temperature, stress ratios, consolidation time, the ratio of compression index to permeability index, and the interface parameters on the consolidation process. Different from many previous studies overlooking the thermal effect on the modulus of the soil, a model has been developed which points out that the final settlement due to consolidation would vary significantly with the ambient temperature. Therefore, the thermal effect must be considered in the consolidation calculation of the freeze–thaw cycle soil in the cold region.
Genetic Background Studies of Eight Common Beta Thalassemia Mutations in Thailand Using β-Globin Gene Haplotype and Phylogenetic Analysis
Authors: Karnpean Rossarin , Tepakhan Wanicha , Suankul Prame , Thingphom Sitthikorn , Poonsawat Apichaya , Thanunchaikunlanun Naritthakarn , Ruangsanngamsiri Rotsakorn , Jomoui Wittaya
Published: August 2022

Single nucleotide polymorphisms are informative for haplotype analysis associated with genetic background and clinical linkage studies of β-thalassemia mutations. Hence, the aim of this study was to investigate five polymorphisms (codon 2 (C/T), IVS II-16 (C/G), IVS II-74 (G/T), IVS II-81 (C/T) and the Hinf I (T/A) polymorphism) on the β-globin gene, related to eight common β-thalassemia mutations in Thailand, including NT-28 (A > G), codon 17 (A > T), codon 19 (A > G), HbE (G > A), IVS I-1 (G > C), IVS I-5 (G > C), codon 41/42 (-TTCT) and IVS II-654 (C > T). The strongest LD (100%) between the β-thalassemia mutation allele and all five SNPs was found in NT-28 (A > G), codon 17 (A > T) and codon 19 (A > G). In the haplotype analysis, we found three haplotypes (H1, H2 and H7) related to Hb E, whereas we only found two haplotypes related to codon 41/42 (-TTCT) (H1, H3) and IVS I-1 (G > C) (H3, H4). Of interest is the finding relating to a single haplotype in the remaining β-thalassemia mutations. Furthermore, phylogenetic tree analysis revealed three clusters of these common β-thalassemia mutations in the Thai population and enabled us to determine the origin of these mutations. Here, we present the results of our study, including four intragenic polymorphisms and the finding that the Hinf I polymorphism could be informative in genetic background analysis, population studies and for predicting the severity of β-thalassemia in Thailand.
Petrography and Geotechnical Characteristics of Aggregates from the Oyo and Mongo Massifs (Chad): Implications for the Construction of Structures
Authors: Al-hadj Hamid Zagalo , Rochette Pierre , Djiddi Mahamat Tahir Abakar
Published: August 2022

The present study focused on the petrography and geotechnics of aggregates of two sites around the city of Mongo for their use in construction. The study area is located in central Chad, in the Guéra province, at the eastern and north-western entrance to the city of Mongo. The area corresponds to a crystalline basement, and granitic massifs are abundant. Two deposits were studied: the Mongo massif, closest to the town of the same name, and the Oyo massif at the eastern exit of Mongo. The petrographic analysis showed that the studied materials are granites, light grey in color, composed of 30% quartz, 15% biotite, 20% feldspar, 30% plagioclase and 5% other minerals. From the geotechnical point of view, the materials of the Mongo site are more resistant to wear compared to those of Oyo which are less resistant. According to the results of micro-Deval and Los Angeles tests, the use of aggregates obtained from the Mongo site granites are usable in base courses for T1–T3 traffic admitting an axle of 8 to 10 tons and in surface dressings, contrary to those of Oyo, which are not favorable in road construction.
Characteristics and Health Risks of Phthalate Ester Contamination in Soil and Plants in Coastal Areas of South China
Authors: Xing Huanhuan , Yu Xiaolong , Huang Jiahui , Du Xiaodong , Wang Mengting , Sun Jianteng , Lu Guining , Tao Xueqin
Published: August 2022

Phthalate esters (PAEs) are widely used as plasticizers in industrial and commercial products, and are classified as endocrine-disrupting compounds. In this study, we investigated the contamination characteristics and health risks of PAEs in the soil–plant system in coastal areas of South China. PAEs were detected in soil and plant samples at all 37 sampling sites. The total concentration of the 15 PAEs in soil samples ranged from 0.445 to 4.437 mg/kg, and the mean concentration was 1.582 ± 0.937 mg/kg. The total concentration of the 15 PAEs in plant samples ranged from 2.176 to 30.276 mg/kg, and the mean concentration was 8.712 ± 5.840 mg/kg. Di(2-Ethylhexyl) phthalate (DEHP) and di-n-butyl phthalate (DnBP) were the major PAEs compounds in all samples. The selected contaminants exhibited completely different spatial distributions within the study area. Notably, higher concentrations of PAEs were found in the coastal Guangdong Province of South China. The average noncarcinogenic risks of Σ6 PAEs were at acceptable levels via dietary and nondietary routes. However, the noncarcinogenic risks posed by DEHP and DBP at some sampling sites were relatively high. Furthermore, dietary and nondietary carcinogenic risks were very low for BBP, but carcinogenic risks posed by DEHP via diet. The results suggest that PAEs in the coastal soil–plant system in South China, through human risk assessment, will induce some adverse effects on human health, especially in children. This study provides an important basis for risk management of PAEs in agriculture, and safety in coastal areas of South China.
Parent-Focused Psychotherapy for the Preventive Management of Chronicity in Anorexia Nervosa: A Case Series
Authors: García-Anaya María , Caballero-Romo Alejandro , González-Macías Laura
Published: August 2022

Background: Anorexia nervosa (AN) is a complex eating disorder where involvement of family plays a central role in first line treatment in adolescents, but which is not so for adults where poor response to treatment is frequent. Given the reluctance of some patients to receive treatment, we set out to explore the hypothesis that certain family dynamics may be involved in the maintenance of the disorder. Methods: We aimed to understand what is underlying in the cases of patients who present clinical improvement with their parents, but not the ones who received a parent-focused psychotherapeutic intervention. We conducted a mixed methods study. On the one hand we performed a case series of 14 patients who dropped out of treatment while their parents actively attended the intervention, and on the other hand, we followed the evolution of the parents of those patients reluctant to continue treatment, through non-participant observation. Results: We present preliminary evidence where we found the parent-focused psychotherapeutic intervention was able to elicit a reflective function of the parents. We also observed that the intervention modified certain family dynamics that could be related to maintaining factors of the disorder. In patients, we found that in parallel to the assistance of their parents to psychotherapeutic treatment, and even when they were receiving no intervention, they showed significant clinical improvement of symptomatology and global functioning; we observed 9 of 14 of them who voluntarily decided to return to pharmacological treatment. Conclusions: This parent-focused intervention elicited changes in reflective functioning of participant parents; the intervention produced favorable changes in family dynamics, which we believe is probably related to improvement of global functioning, symptomatology, and insight of patients.
Impact of Physical Contact on Preterm Infants’ Vital Sign Response to Live Music Therapy
Authors: Kobus Susann , Diezel Marlis , Dewan Monia Vanessa , Huening Britta , Dathe Anne-Kathrin , Felderhoff-Mueser Ursula , Bruns Nora
Published: August 2022

Evidence that music therapy stabilises vital parameters in preterm infants is growing, but the optimal setting for therapy is still under investigation. Our study aimed to quantify the effect of physical contact during live music therapy in preterm infants born < 32 weeks’ gestational age (GA) on post-therapy vital sign values. Live music therapy was delivered twice-weekly until discharge from hospital to 40 stable infants < 32 weeks’ GA. Baseline and post-therapy heart rate, respiratory rate, oxygen saturation and physical contact during each session were recorded. 159 sessions were performed with, and 444 sessions without, physical contact. Descriptive and multivariable regression analyses based on directed acyclic graphs were performed. The mean GA was 28.6 ± 2.6 weeks, and 26 (65%) infants were male. Mean absolute values for heart and respiratory rates lowered during music therapy regardless of physical contact. The mean post-therapy SaO2 was higher compared to baseline values regardless of physical contact (mean differences −8.6 beats/min; −13.3 breaths/min and +2.0%). There were no clinically relevant changes in vital sign responses between therapy sessions, with or without physical contact, or adjusted post-therapy values for any of the studied vital signs. Physical contact caused better baseline and post-therapy vital sign values but did not enhance the vital sign response to music therapy. Thus, the effect of music therapy on preterm infants’ vital signs is independent of physical contact and parents’ presence during music therapy in the neonatal intensive care unit.
Caregivers’ Compliance and Perception of Daycare Centers—A Community-Based Childhood Drowning Prevention Intervention Implemented in Rural Bangladesh
Authors: Ashraf Lamisa , Agrawal Priyanka , Rahman Aminur , Bhuiyan Md. Al Amin , Salam Shumona Sharmin , Li Qingfeng , Bachani Abdulgafoor M.
Published: August 2022

Drowning was one of the most prevalent causes of death worldwide for children under five in 2020. Drowning was the second leading cause of death for children under five in Bangladesh, while 58% of all deaths in the 1–5 years old age group resulted from drowning. Adult supervision helps prevent child drowning in rural areas where water bodies are easily accessible and located very close to homes. This paper aims to assess caregivers’ compliance and perception of community daycare centers in rural Bangladesh, piloted as a child drowning prevention intervention. In this longitudinal study, each child enrolled in the daycare intervention was visited and data on compliance and satisfaction with the daycare were collected. Descriptive statistics on daycare attendance, patterns of supervision, and caregivers’ perceptions about daycare were reported. When inquired about daycare attendance (n = 226,552), a total of 77.4% of children (n = 175,321) were found to attend daycare. The distance from homes and an adult’s unavailability to take the child to daycare were the most common reasons for not attending or discontinuing enrollment. The majority of children (76.4%) were supervised by their mothers during daycare closures. A total of 67.7% of respondents perceived daycare to be a safe place, where children also developed cognitive (51.7%) and social skills (50.6%). There were no incidences of drowning among children while attending daycare. Rural families were found to be compliant with the daycare and professed it to be a safe place protecting children from drowning and other injuries, while allowing them to focus on household chores or income-generating activities. These findings indicate a potential for the expansion of this intervention in rural Bangladesh and similar settings.
Regional Potential Wind Erosion Simulation Using Different Models in the Agro-Pastoral Ecotone of Northern China
Authors: Liu Jun , Wang Xuyang , Zhang Li , Guo Zhongling , Chang Chunping , Du Heqiang , Wang Haibing , Wang Rende , Li Jifeng , Li Qing
Published: August 2022

Wind erosion is crucial for assessing regional ecosystem services and sustainable development. The Agro-Pastoral Ecotone of northern China (APEC) is a typical region undergoing wind erosion and soil degradation. In this study, the National Wind Erosion Survey Model of China, the Integrated Wind Erosion Modeling System, and the regional versions of the Revised Wind Erosion Equation and Wind Erosion Prediction System were used to evaluate the regional potential wind erosion of the APEC during 2000 and 2012. The results showed that the potential wind erosion predicted by National Wind Erosion Survey Model of China (NWESMC), Revised Wind Erosion Equation (RWEQ), Wind Erosion Prediction System (WEPS), and Integrated Wind Erosion Modeling System (IWEMS) were significantly related to the observed wind erosion collected from published literature, but the observed data were generally smaller than the predicted values. The average potential wind erosions were 12.58, 25.87, 52.63, and 58.72 t hm−2 a−1 for NWESMC, RWEQ, WEPS, and IWEMS, respectively, while the spatial pattern and temporal trend of annual potential wind erosion were similar for different wind erosion models. Wind speed, soil moisture, and vegetation coverage were the dominant factors affecting regional wind erosion estimation. These results highlight that it is necessary to comprehensively calibrate and validate the selected wind erosion models. A long-term standard wind erosion monitoring network is urgently required. This study can serve as a useful reference for improving wind erosion models.
“We Cause a Ruckus”: Exploring How Indigenous Youth Navigate the Challenges of Community Engagement and Leadership
Authors: Shepherd Robert P. , Orchard Treena R.
Published: August 2022

Using qualitative data from an interdisciplinary research project about mental health and community engagement with Indigenous youth in Kasabonika Lake First Nation (Ontario, Canada), this paper explores the factors that constrain and facilitate their ability to contribute to the well-being of their community. Case studies are employed to demonstrate how the youth navigate complex social and structural conditions within the context of on-going colonization through federal and provincial governance arrangements, to make a difference in the place they call home and forge unique in-roads that reflect their generational realities and aspirations. The paper contributes to ongoing discussions related to mental health, self-determination, and resilience research.
Effectiveness of Digital Cognitive Behavior Therapy for the Treatment of Insomnia: Spillover Effects of dCBT
Authors: Li Xinyi , Liu Hongying , Kuang Ming , Li Haijiang , He Wen , Luo Junlong
Published: August 2022

The effects of digital Cognitive Behavior Therapy for insomnia (dCBT-i) on sleep quality have been previously demonstrated but the spillover effects on fatigue, flow (a state of immersion in activities of interest), and cognitive flexibility remain unclear. The current study examined the effectiveness of dCBT-i. A total of 97 college students (20.96 ± 1.87 years, 73.1% female students) were randomly selected from a shortlist and divided into sleep intervention (n = 39), conventional education (n = 37), and healthy control (n = 21) groups. Task switching paradigm, Fatigue Severity Scale (FSS), Flow Experience Scale (FES), and the Chinese version of the Pittsburgh Sleep Quality Index (CPSQI) were measured pre- and post-intervention. Results show that the sleep quality of the intervention group improved, and fatigue was relieved. Participants in the sleep intervention group had increased flow experience scores post-intervention and improved cognitive flexibility. The control group’s sleep quality deteriorated and fatigue level increased. dCBT-i can not only achieve a significant improvement in sleep quality and reduce fatigue, but also improve learning abilities, quality of life, flow, and cognitive flexibility. Future research should pay attention to indicators such as work efficiency, sedative use, and the durability and stability of such effects.
Human-Centered Explainable Artificial Intelligence: Automotive Occupational Health Protection Profiles in Prevention Musculoskeletal Symptoms
Authors: Mollaei Nafiseh , Fujao Carlos , Silva Luis , Rodrigues Joao , Cepeda Catia , Gamboa Hugo
Published: August 2022

In automotive and industrial settings, occupational physicians are responsible for monitoring workers’ health protection profiles. Workers’ Functional Work Ability (FWA) status is used to create Occupational Health Protection Profiles (OHPP). This is a novel longitudinal study in comparison with previous research that has predominantly relied on the causality and explainability of human-understandable models for industrial technical teams like ergonomists. The application of artificial intelligence can support the decision-making to go from a worker’s Functional Work Ability to explanations by integrating explainability into medical (restriction) and support in contexts of individual, work-related, and organizational risk conditions. A sample of 7857 for the prognosis part of OHPP based on Functional Work Ability in the Portuguese language in the automotive industry was taken from 2019 to 2021. The most suitable regression models to predict the next medical appointment for the workers’ body parts protection were the models based on CatBoost regression, with an RMSLE of 0.84 and 1.23 weeks (mean error), respectively. CatBoost algorithm is also used to predict the next body part severity of OHPP. This information can help our understanding of potential risk factors for OHPP and identify warning signs of the early stages of musculoskeletal symptoms and work-related absenteeism.
Readability of Commonly Used Quality of Life Outcome Measures for Youth Self-Report
Authors: Krause Karolin R. , Jacob Jenna , Szatmari Peter , Hayes Daniel
Published: August 2022

Self-report measures are central in capturing young people’s perspectives on mental health concerns and treatment outcomes. For children and adolescents to complete such measures meaningfully and independently, the reading difficulty must match their reading ability. Prior research suggests a frequent mismatch for mental health symptom measures. Similar analyses are lacking for measures of Quality of Life (QoL). We analysed the readability of 13 commonly used QoL self-report measures for children and adolescents aged 6 to 18 years by computing five readability formulas and a mean reading age across formulas. Across measures, the mean reading age for item sets was 10.7 years (SD = 1.2). For almost two-thirds of the questionnaires, the required reading age exceeded the minimum age of the target group by at least one year, with an average discrepancy of 3.0 years (SD = 1.2). Questionnaires with matching reading ages primarily targeted adolescents. Our study suggests a frequent mismatch between the reading difficulty of QoL self-report measures for pre-adolescent children and this group’s expected reading ability. Such discrepancies risk undermining the validity of measurement, especially where children also have learning or attention difficulties. Readability should be critically considered in measure development, as one aspect of the content validity of self-report measures for youth.
A Comparative Study on Intention to Use Digital Therapeutics: MZ Generation and Baby Boomers’ Digital Therapeutics Use Intention in Korea
Authors: Kim Soojin , Eom Juhee , Shim Jiwon
Published: August 2022

Purpose: The aim of this study lies in articulating the relationship between digital literacy and private concern as a predictor of intention to use digital therapeutics. Materials and Methods: An online survey was conducted through a research company among 600 panels. The survey questionnaire consists of items of digital literacy, privacy concern, perceptions, and intention to use digital therapeutics, and the participants were asked to fill out the questions online. A structural equation model was established, and the difference in paths between the MZ generation and the baby boomers were examined. Results: Public perception of digital therapeutics was categorized into seven factors and the dimension of digital literacy as categorized into three factors. For the MZ generation, digital literacy and privacy concern both directly and indirectly affect the digital therapeutics use intention, in that higher the level of digital literacy and the lower the privacy concern, digital therapeutics perception and digital therapeutics use intention becomes intensified. For the baby boomers, digital literacy and privacy concern positively affect digital therapeutics perception, and as digital therapeutics perception becomes more positive, digital therapeutics use intention also increases. Direct effects of digital literacy and privacy concern to digital therapeutics use intention were not found for the baby boomers. Conclusion: In order to promote the use of digital therapeutics, it is common for the MZ generation and baby boomers to develop a positive perception toward digital therapeutics by cultivating digital literacy. For the MZ generation, privacy concerns need to be cautiously considered as they negatively affect the intention to use digital therapeutics.
The Relationship between Postmenopausal Women’s Self-Esteem and Physical Activity Level—A Survey Study from Poland
Authors: Dąbrowska-Galas Magdalena , Drosdzol-Cop Agnieszka
Published: August 2022

Introduction: Physical inactivity has become one of the major public health and economic concerns in Western societies. The consequences of physical inactivity are associated with many physical problems, however, the influence of physical activity (PA) on psychological health is unclear. The aims of our study were to assess self-esteem and physical activity levels in postmenopausal women and to examine the association between physical activity levels and self-esteem in this group. Material and methods: Survey research was conducted on postmenopausal women aged M = 58.81 ± 7.68 in women’s health clinics in Silesia, Poland. The total number of participants was 131, and 18 were excluded. A questionnaire with socio-demographic data and other international questionnaires were used: International Physical Activity Questionnaire, Rosenberg Self-Esteem Scale and Beck Depression inventory. Results: 78.76% of postmenopausal women were physically active. Mean value of MET-min/week was M = 1543.46 ± 1060.92. A total of 11.51% of women reported low self-esteem, with the mean total value of SES M = 31.79 ± 2.93. There was a lack of correlation between total IPAQ score and self-esteem (r = −0.241, p = 0.01). Conclusions: Postmenopausal women have mostly average self-esteem. They are generally active, and walking is the most common form of physical activity, however, a higher PA level does not influence self-esteem.
Age and Sex Differences in the State and Relationships between Process and Product Assessments of Fundamental-Motor Skills in Five to Eight-Year-Olds: The ExAMIN Youth SA Study
Authors: Pienaar Anita E. , Monyeki Makama A. , Coetzee Dané , Gerber Barry , du Plessis Wilmarié , du Plessis Aletta M. , Kruger Ruan
Published: August 2022

Adequate development of Fundamental Motor Skills (FMS) at a young age benefit holistic development and positive health outcomes. This study determined age and sex developmental differences in the state and the relationships between process and product assessments of four fundamental-motor skills (FMS) in five to eight-year-olds. An availability sample of 636 children; 291 boys, 345 girls, mean age of 6.8 ± 0.97 years in the North West Province of South Africa participated in the study. Spearman rank order correlations analyzed relationships between assessments, while sex and age differences were examined using independent t-testing and one-way ANOVA. Age showed significant developmental trajectories in all FMS. Older children were found to be more at risk for not learning FMS to mastery, while unique developmental patterns were also established compared to international trends. Strong to moderate significant practical associations (p < 0.05) emerged between process and product assessments in catching (r = 0.79), jumping (r = 0.40) running (r = −0.33) and kicking (r = 0.20), while also confirming that the strength of the associations varies depending upon the skill type. Associations strengthened with increasing age, were higher in girls in all FMS, while associations between behavioral criteria in all FMS also differed between FMS and sexes. These strong associations, need to be taken into consideration during the development of FMS towards obtaining full mastery.
COVID-19 and the Immune Response: A Multi-Phasic Approach to the Treatment of COVID-19
Authors: Sapir Tzuriel , Averch Zaelig , Lerman Brian , Bodzin Abraham , Fishman Yeshaya , Maitra Radhashree
Published: August 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a viral agent that causes Coronavirus disease 2019 (COVID-19), a disease that causes flu-like symptoms that, when exacerbated, can have life-threatening consequences. COVID-19 has been linked to persistent symptoms, sequelae, and medical complications that can last months after the initial infection. This systematic review aims to elucidate the innate and adaptive immune mechanisms involved and identify potential characteristics of COVID-19 pathology that may increase symptom duration. We also describe he three different stages of COVID-19—viral replication, immune hyperactivation, and post-acute sequelae—as well as each phase’s corresponding immune response. Finally, we use this multiphasic approach to describe different treatment approaches for each of the three stages—antivirals, immunosuppressants and monoclonal antibodies, and continued immunosuppressants—to fully curate the treatment to the stage of disease.
Cell Architecture-Dependent Constraints: Critical Safeguards to Carcinogenesis
Authors: Khalil Komal , Eon Alice , Janody Florence
Published: August 2022

Animal cells display great diversity in their shape. These morphological characteristics result from crosstalk between the plasma membrane and the force-generating capacities of the cytoskeleton macromolecules. Changes in cell shape are not merely byproducts of cell fate determinants, they also actively drive cell fate decisions, including proliferation and differentiation. Global and local changes in cell shape alter the transcriptional program by a multitude of mechanisms, including the regulation of physical links between the plasma membrane and the nuclear envelope and the mechanical modulation of cation channels and signalling molecules. It is therefore not surprising that anomalies in cell shape contribute to several diseases, including cancer. In this review, we discuss the possibility that the constraints imposed by cell shape determine the behaviour of normal and pro-tumour cells by organizing the whole interconnected regulatory network. In turn, cell behaviour might stabilize cells into discrete shapes. However, to progress towards a fully transformed phenotype and to acquire plasticity properties, pro-tumour cells might need to escape these cell shape restrictions. Thus, robust controls of the cell shape machinery may represent a critical safeguard against carcinogenesis.
CRISPR/Cas9-Mediated Targeted DNA Integration: Rearrangements at the Junction of Plant and Plasmid DNA
Authors: Permyakova Natalya V. , Marenkova Tatyana V. , Belavin Pavel A. , Zagorskaya Alla A. , Sidorchuk Yuriy V. , Deineko Elena V.
Published: August 2022

Targeted DNA integration into known locations in the genome has potential advantages over the random insertional events typically achieved using conventional means of genetic modification. We studied the presence and extent of DNA rearrangements at the junction of plant and transgenic DNA in five lines of Arabidopsis thaliana suspension cells carrying a site-specific integration of target genes. Two types of templates were used to obtain knock-ins, differing in the presence or absence of flanking DNA homologous to the target site in the genome. For the targeted insertion, we selected the region of the histone H3.3 gene with a very high constitutive level of expression. Our studies showed that all five obtained knock-in cell lines have rearrangements at the borders of the integrated sequence. Significant rearrangements, about 100 or more bp from the side of the right flank, were found in all five plant lines. Reorganizations from the left flank at more than 17 bp were found in three out of five lines. The fact that rearrangements were detected for both variants of the knock-in template (with and without flanks) indicates that the presence of flanks does not affect the occurrence of mutations.
Hydrogen Sulfide and Substance P Levels in Patients with Escherichia coli and Klebsiella pneumoniae Bacteraemia
Authors: Manandhar Sumeet , Scott-Thomas Amy , Harrington Michael , Sinha Priyanka , Pilbrow Anna , Richards Arthur Mark , Cameron Vicky , Bhatia Madhav , Chambers Stephen T.
Published: August 2022

Hydrogen sulfide (H2S) and substance P (SP) are known from animal models and in vitro studies as proinflammatory mediators. In this study, peripheral blood concentrations of H2S and SP were measured in patients with Escherichia coli or Klebsiella pneumoniae bacteraemia. Fifty patients were recruited from general wards at Christchurch Hospital, during 2020–2021. Samples from age- and sex-matched healthy subjects previously recruited as controls for studies of cardiovascular disease were used as controls. The concentrations of H2S were higher than controls on day 0, day 1, and day 2, and SP was higher than controls on all 4 days. The concentrations of H2S were highest on day 0, whereas SP concentrations were higher on day 2 than other days. Interleukin-6 and C-reactive protein were significantly higher on day 0 and day 1, respectively. The concentrations of H2S and SP did not differ between 15 non-septic (SIRS 0-1) and the 35 septic subjects (SIRS ≥ 2). Substance P concentrations were higher in subjects with abdominal infection than urinary tract infections on day 0 (p = 0.0002) and day 1 (p = 0.0091). In conclusion, the peak H2S concentrations precede the SP peak in patients with Gram-negative bacteraemia, but this response varies with the site of infection.
Impact of Pancreatitis-Associated Protein on Newborn Screening Outcomes and Detection of CFTR-Related Metabolic Syndrome (CRMS)/Cystic Fibrosis Screen Positive, Inconclusive Diagnosis (CFSPID): A Monocentric Prospective Pilot Experience
Authors: Bianchimani Chiara , Dolce Daniela , Centrone Claudia , Campana Silvia , Ravenni Novella , Orioli Tommaso , Camera Erica , Mergni Gianfranco , Fevola Cristina , Bonomi Paolo , Taccetti Giovanni , Terlizzi Vito
Published: August 2022

Pancreatitis-Associated Protein (PAP)-based Cystic Fibrosis (CF) newborn bloodspot screening (NBS) protocols detect less CFTR-Related Metabolic Syndrome (CRMS)/CF Screen Positive, Inconclusive Diagnosis (CFSPID). We prospectively evaluated the impact of PAP as the second step of the CF NBS protocol, before the CFTR genetic analysis, on NBS outcomes and CRMS/CFSPID detection in the Tuscany region, Italy. In parallel to the usual protocol (IRT/DNA, protocol 1), PAP was analyzed in IRT-positive infants (IRT/PAP/DNA, protocol 2) from 1 June 2020 until 31 May 2022. We defined an infant as NBS positive if PAP was >1.8 μg/L for IRT value 99th percentile-100 μg/L or >0.6 μg/L for IRT value >100 μg/L. To increase the positive predictive value (PPV) of protocol 2, we retrospectively lowered the upper IRT range value from 100 to 90 μg/L (modified protocol 2). We identified 8 CF and 13 CRMS/CFSPID with protocol 1, 5 CF and 5 CRMS/CFSPID with protocol 2 and 8 CF and 5 CRMS/CFSPID with modified protocol 2. With the PAP-based protocols, we observed a reduction of sweat tests, healthy carrier detection and a significant increase in PPV to 15.38%. Further data are needed in order to evaluate the outcomes of CRMS/CFSPID after a long follow-up.
Uterus Transplantation: Revisiting the Question of Deceased Donors versus Living Donors for Organ Procurement
Authors: Frisch Emily H. , Falcone Tommaso , Flyckt Rebecca L. , Tzakis Andreas G. , Kodish Eric , Richards Elliott G.
Published: August 2022

Uterus transplantation is a surgical treatment for women with congenital or acquired uterine factor infertility. While uterus transplantation is a life-enhancing transplant that is commonly categorized as a vascular composite allograft (e.g., face or hand), it is similar to many solid organ transplants (e.g., kidney) in that both living donors (LDs) and deceased donors (DDs) can be utilized for organ procurement. While many endpoints appear to be similar for LD and DD transplants (including graft survival, time to menses, livebirth rates), there are key medical, technical, ethical, and logistical differences between these modalities. Primary considerations in favor of a LD model include thorough screening of donors, enhanced logistics, and greater donor availability. The primary consideration in favor of a DD model is the lack of physical or psychological harm to a living donor. Other important factors, that may not clearly favor one approach over the other, are important to include in discussions of LD vs. DD models. We favor a stepwise approach to uterus transplantation, one in which programs first begin with DD procurement before attempting LD procurement to maximize successful organ recovery and to minimize potential harms to a living donor.
D-Lactic Acid Production from Sugarcane Bagasse by Genetically Engineered Saccharomyces cerevisiae
Authors: Sornlek Warasirin , Sae-Tang Kittapong , Watcharawipas Akaraphol , Wongwisansri Sriwan , Tanapongpipat Sutipa , Eurwilaichtr Lily , Champreda Verawat , Runguphan Weerawat , Schaap Peter J. , Martins dos Santos Vitor A. P.
Published: August 2022

Lactic acid (LA) is a promising bio-based chemical that has broad applications in food, nutraceutical, and bioplastic industries. However, production of the D-form of LA (D-LA) from fermentative organisms is lacking. In this study, Saccharomyces cerevisiae harboring the D-lactate dehydrogenase (DLDH) gene from Leuconostoc mesenteroides was constructed (CEN.PK2_DLDH). To increase D-LA production, the CRISPR/Cas12a system was used for the deletion of gpd1, gpd2, and adh1 to minimize glycerol and ethanol production. Although an improved D-LA titer was observed for both CEN.PK2_DLDHΔgpd and CEN.PK2_DLDHΔgpdΔadh1, growth impairment was observed. To enhance the D-LA productivity, CEN.PK2_DLDHΔgpd was crossed with the weak acid-tolerant S. cerevisiae BCC39850. The isolated hybrid2 showed a maximum D-LA concentration of 23.41 ± 1.65 g/L, equivalent to the improvement in productivity and yield by 2.2 and 1.5 folds, respectively. The simultaneous saccharification and fermentation using alkaline pretreated sugarcane bagasse by the hybrid2 led to an improved D-LA conversion yield on both the washed solid and whole slurry (0.33 and 0.24 g/g glucan). Our findings show the exploitation of natural yeast diversity and the potential strategy of gene editing combined with conventional breeding on improving the performance of S. cerevisiae for the production of industrially potent products.