bluuebunny/crossref_metadata_2025 huggingface dataset:
Rethinking Water Sustainability: Precipitation Changes in the Peruvian Andes in the Face of Climate Change
Authors: Peña Valeria Llactayo , Valdivia Jairo , Yarleque Christian , Callañaupa Stephany , Villalobos-Puma Elver , Guizado David , Alvarado-Lugo Robert
Published: June 2023

In high-altitude regions, such as the Peruvian Andes, understanding the transformation of precipitation types under climate change is critical to the sustainability of water resources and the survival of glaciers. Conventional wisdom has primarily focused on the snow-rain dichotomy, often overlooking the potential importance of graupel and hail. In this study, we offer a fresh perspective on this issue, investigating the distribution and types of precipitation on a tropical glacier in the Central Andes. We utilized data from an optical-laser disdrometer and compact weather station installed at 4709 m ASL, combined with future climate scenarios from the CMIP6 project, to model potential future changes in precipitation, including the often-ignored hydrometeor forms of graupel and hail. Our findings highlight that increasing temperatures could lead to significant reductions in solid-phase precipitation, including graupel and hail, with implications for the mass balance of Andean glaciers. For instance, a 2°C rise might result in less than 10\% of precipitation as solid, transforming the hydrological processes of the region. The two future climate scenarios from the CMIP6 project, SSP2-4.5 and SSP5-8.5, offer a broad perspective on potential climate outcomes that could impact precipitation patterns in the Andes. Our study underscores the need to revisit and expand our understanding of high-altitude precipitation in the face of climate change, paving the way for improved water resource management strategies and sustainable glacier preservation efforts in these fragile ecosystems.
Economic analysis of mode of birth in women with low-lying placenta
Authors: Colciago Elisabetta , Ferrara Pietro , Tessitore Isadora Vaglio , Mantovani Lorenzo Giovanni , Vergani Patrizia , Ornaghi Sara
Published: June 2023

Introduction Alongside health consequences, cesarean delivery (CD) has been associated with increased healthcare resource utilization, including multiple obstetric interventions and their related costs. While there is consensus that CD should be performed in case of placenta previa, the most appropriate mode of birth in women with low-lying placenta is still controversial, due to lack of robust data. The aim of this study was to evaluate the healthcare resource utilization and economic impact on the Italian healthcare system of vaginal birth (VB) and CD in women with a low-lying placenta, from a national healthcare service perspective. Method For this retrospective cohort study, patient-level real-world data were derived from a cohort of women with low-lying placenta confirmed at 28–32 weeks’ gestation during the third trimester scan. Low-lying placenta was diagnosed when the inferior placental edge was within 1 to 20 mm from the internal. A cost minimization analysis (CMA) was conducted to compare VB and CD. Since Diagnosis-Related-Group payment may not reflect the real hospital resources used, a micro-costing analysis (MCA) was performed to provide a more comprehensive evaluation of the economic impact of modes of birth. Results The study included 86 women with low-lying placenta at the third trimester scan, 49 (57%) had a VB and 37 (43%) underwent a CD. The CMA showed an economically marginal difference between VB and CD, especially when considering opportunity costs associated with the time needed to look after women. However, the MCA identified charges for each VB being about half of those for each CD. Conclusion The use of patient-level real-world data made it possible to generate basic information to assess the value of available interventions in case of low-lying placenta. A VB should be promoted as a safe option to women with low-lying placenta, avoiding further burden on the healthcare system’s limited resources.
Missense mutation (Ser 654 Leu) in ITGA8 gene leads to renal hypodysplasia: A Case Report
Authors: Singh Kumar Gautam , Moorthy Anbalagan
Published: June 2023

Renal hypodysplasia is a congenital anomaly of the kidney that occurs when part of a kidney does not fully develop in the womb. A lot of genes have been when mutated, results in renal dysplasia. This has encouraged us to search for additional genes and gene variants that may be linked to renal anomalies. Using next-generation sequencing combined with Sanger sequencing, we correlated a variant of the ITGA8 gene (NM_003638.2:c.1961C > T; p.Ser654Leu) to renal hypodysplasia. Detailed studies on this variant revealed that Ser 654 is conserved across different species and the mutation is present in the extracellular domain of the proteins, which has an important role in ligand binding and other protein-protein interactions. For the first time, we present the clinical correlation of ITGA8 gene variant (Ser654Leu) to renal dysplasia.
An in-depth Analysis of Pruritus: Insights from Dermoscopy
Authors: Akca Hanife Merve , Metin Zuhal
Published: June 2023

A dermoscope is a non-invasive diagnostic tool used to visualise subtle clinical patterns of skin lesions and subsurface skin structures not visible to the naked eye. Several dermoscopic patterns exhibit consistent associations with specific diseases, serving as valuable diagnostic indicators to differentiate primary and secondary skin lesions. We evaluated the dermoscopic patterns associated with pruritus and compared these patterns based on specific diagnoses. We performed dermoscopy on skin lesions in 299 patients who presented with itching at the outpatient dermatology clinics of Karaman Training and Research Hospital between June 2022 and August 2022. We documented various dermoscopic findings, such as red globules, purple globules, fabric fiber, white scale, comedone-like openings, follicular plugs,brown dots andpigment network, glomerular vessels, delta signs, and yellow crusts. The study included 299 patients ages 17–89 (mean age: 47.53 ± 17.67) years. Among these patients, 60.2% were females and 39.8% were males. Cutaneous xerosis was observed in 35.8% of the patients, scabies in 19.1%, Prurigo nodularis and atopic dermatitis in 11%, lichen simplex chronicus in 7.7%, pityriasis lichenoides chronica and pityriasis rosea in 2.3% and senile pruritus in 1.7%. The most commonly observed dermoscopic signs included irregular white scales (30.8%), red globules (20.1%), an erythematous background (16.4%), the delta sign (9.4%), nonspecific signs (8.7%), hemorrhagic crust (8%) and arborizing vessels (7.7%). Compared to all other age groups, the incidence of delta signs was significantly higher in patients aged < 20 years (31.6%), whereas the incidence of brown spots was significantly higher in patients aged 30–39 years. Dermoscopy is crucial in the identification of the differential diagnoses of pruritus, a commonly encountered condition in dermatological practice.
Improve the management of cancer-related cognitive impairment in clinical settings: a European Delphi study
Authors: Duivon Mylène , Lange Marie , Binarelli Giulia , Lefel Johan , Hardy-Léger Isabelle , Kiasuwa-Mbengi Régine , Méric Jean-Baptiste , Charles Cécile , Joly Florence
Published: June 2023

Purpose
Cancer-related cognitive impairment (CRCI) is under-addressed by healthcare professionals owing to a lack of clinical management guidelines. This European Delphi study aims to propose recommendations to healthcare professionals for the management of CRCI in patients with non-central nervous system (non-CNS) cancers.
Methods
The survey included European professionals (psychologists, physicians, researchers) who are experts in CRCI. Twenty-two recommendations were developed based on a literature review and authors’ clinical experience, split into three categories: screening, cognitive assessment, intervention. The Delphi method was used. Experts assessed the clinical relevancy of recommendations on a 9-point Likert scale in three rounds. A recommendation was accepted if all votes were between 7 and 9.
Results
Eighteen professionals voted and accepted 15 recommendations. Experts recommended the systematic screening of CRCI, followed by a short objective cognitive assessment, if complaints screened. A comprehensive evaluation is recommended if CRCI persists 6-months post-treatment. Cognitive rehabilitation, physical activity, meditative-movement therapy, and multimodal intervention should be offered. No consensus was reached for frequency and duration of interventions, the professional to administer cognitive rehabilitation and the use of meditation and cognitive training without psychoeducation.
Conclusions
This survey provides 15 recommendations to assist healthcare professionals in detecting, assessing and offering interventions for CRCI to patients with non-CNS cancers.
Implications for Cancer Survivors
These recommendations should be included in supportive care to help healthcare professionals to detect CRCI and thus to propose the best available intervention for patients with cognitive complaints. Developing CRCI management in clinical settings would improve patients’ quality of life.
Outcomes of ovarian-sparing surgery in children with ovarian neoplasm: A meta-analysis and meta-regression
Authors: Lin Hao , Jiang Hongyu , Zhao Shuai , Xia Xuehong , Liu Ziyu , Yang Hong , Li Miaomiao , Jin Mingjun , Tian Qi , Dong Liang , Cui Hualei
Published: June 2023

Objectives.
Ovarian-sparing surgery (OSS) is increasingly used to treat various ovarian neoplasms (ON) in children. The feasibility and prognosis of OSS on ON are still being explored. The aim of this research was to demonstrate the clinical results of implementing OSS in children diagnosed with ON.
Methods.
A thorough search was conducted on PubMed, Cochrane Library, and Embase databases to identify relevant articles. The study calculated the recurrence rate, incidence of benign cases and OSS, along with a 95% confidence interval (CI).
Results.
The study included a total of 14 relevant studies involving 1577 patients. The recurrence rate of ON was 2.0% (95% CI: 1.0%-3.1%), the benign rate was 85.5% (95% CI: 81.5%-89.4%), and the rate of OSS was 60.0% (95% CI: 54.3%-65.6%), the rate of OSS in benign tumors was 497.1% (95% CI: 95.4%-98.8%). As for the distribution of ON: 647 cases (41.2%) of non-neoplastic cysts, 580 cases (36.9%) of germ cell tumors, 279 cases (17.7%) of epithelial tumors, and 61 cases (3.9%) of Sex cord-stromal tumor.
Conclusions.
The results of this meta-analysis suggest that the majority of ON in children is benign and has a meager tumor recurrence rate. TSS should be provided to children with benign lesions to ensure future hormone secretion and reproductive function.
Environmental House Calls Can Reduce Symptoms of Chemical Intolerance: A Demonstration of Personalized Exposure Medicine
Authors: Perales Roger , Rincon Rudy , Forster Jackie V. , Palmer Raymond F. , Hernandez Jessica F. , Bayles Bryan , Grimes Carl , Jaén Carlos R. , Miller Claudia S.
Published: June 2023

Aim The goal of this investigation was to 1) identify exposure sources in the home, 2) teach occupants how to remove or replace them, and 3) determine whether measured levels and reported symptoms could be reduced by these changes.Background Chemical intolerance (CI) is an international public health and clinical concern, but few resources are available to address patients’ often disabling symptoms. Numerous studies show that levels of indoor air pollutants can be two-to-five (or more) times higher than outdoor levels. Fragranced consumer products, including cleaning supplies, air fresheners, and personal care products are symptom triggers commonly reported by susceptible individuals.Methods A team of professionals trained and led by a physician/industrial hygienist and two certified indoor air quality specialists conducted a series of five structured Environmental House Calls (EHCs) in 37 homes of patients reporting chemical intolerances.Results We report three case studies demonstrating that an appropriately structured home intervention can teach occupants how to reduce indoor air exposures and associated symptoms. Symptom improvement, documented using the QEESI Symptom Star, corresponded with reduction of indoor air volatile organic compounds, most notably fragrances.Discussion We address the long-standing dilemma that worldwide reports of fragrance sensitivity have not previously been confirmed by human or animal challenge studies. Our ancient immune systems’ “first responders,” mast cells, which evolved 500 million years ago, can be sensitized by synthetic organic chemicals whose production and use has grown exponentially since WWII. We propose that these chemicals, which include now-ubiquitous fragrances, trigger mast cell degranulation and inflammatory mediator release in the olfactory-limbic tract, thus altering cerebral blood flow and impairing mood, memory, and concentration (so-called “brain fog”). The time has come to translate these research findings into clinical and public health practice.
New insights on Middle and Upper Eocene paleogeography in central and southeastern Tunisia (Gulf of Gabes)
Authors: Njahi-Derbali Zahra , Kassebi Nadhem , Touir Jamel
Published: June 2023

The present work is a contribution to the study of the Middle and Upper Eocene series in the Gulf of Gabes. It aims to study the spatio-temporal variation of the lithofacies in 26 wells. This work is based on the review of the logging data of these wells. A lithostratigraphic correlation and a structural one are established in order to control the relationship between spatio-temporal variations of thickness and lithofacies and early NW-SE faults activities and the resulting structural framework. The present work confirms the spatial lithofacies distribution according NW-SE belts as already mentioned in previous works. In addition, this work shows the basic role of the contemporaneous structural framework as testified by the abrupt spatial variation of both thickness and lithofacies. The sedimentary substratum was cut into piano-key like structure with open marine shallow-water lithofacies on the uplift structures and deep-water low energy restricted lithofacies within the depression structures. Locally some particular lithofacies occur in relation with the hydrodynamic context of the study area with patch-reef windward position and glauconite and organic matter-rich deposits in leeward position. The vertical variation of lithofacies confirms the role of the early tectonic activities, such as during the deposit of Cherahil A and Cherahil B units, the NW-SE oriented faults were rather active, whereas, during the deposit of the median Siouf/Reineche unit the faults were in quiescence testified by the uniformization of shallow carbonate sedimentation. The Middle and Upper Eocene plat-form consists of an irregular cut plat-form.
Is the Ecosystem Services approach incorporated into road development projects in Brazil?
Authors: Neumann Alexandre Guimarães Bilich , Roig Henrique Llacer
Published: June 2023

The aim of this article is to evaluate how the Ecosystem Services (ES) approach is perceived in the environmental assessment of road projects at the federal level in Brazil. An assessment was conducted with the employees of the Brazilian National Department of Transport Infrastructure (DNIT), which is the largest road developer in the country, and an evaluation was also carried out on the environmental licenses issued by the licensing agencies. To make this research possible, a questionnaire was applied to the employees working in the environmental area of the Department, face-to-face meetings were held to gather perceptions, and 12 environmental licenses issued in favor of the DNIT were evaluated. Thus, with these data it was possible to conclude that the view of ES is influenced by the profile of the employee, and that in the majority there is a tendency to attribute greater importance to services of the regulating and provisioning type, while environmental licenses tend to be more balanced among the ES categories, with a tendency to attribute greater importance to cultural ES, especially when traditional communities are involved in the licensing. Hence, it can be inferred that although not a structured perspective, the ES approach appears to exert some impact on road ventures in Brazil.
Decoding inflammation: GARP, miR-142-3-p, and MALAT1 as novel inflammatory biomarkers of IBD
Authors: Lahimchi Mohammad Reza , Mohammadnia-Afrouzi Mousa , Baharlou Rasoul , Haghmorad Dariush , Abedi Seyed Hassan , Arjmandi Delaram , Yousefi Bahman
Published: June 2023

Purpose: Inflammatory bowel disease (IBD) is a life-threatening disorder of the gastrointestinal tract. For the first time, we studied the role of GARP, a crucial regulator of TGF-β synthesis, in Crohn's disease (CD) and ulcerative colitis (UC) patients. We also investigated the upstream regulatory Non-coding RNAs of GARP, namely Lnc-MALAT1 and miR-142-3p. This research sheds light on the mechanisms underlying the development of inflammation in IBD.Methods: A peripheral blood sample was collected from 22 patients with CD, 22 patients with UC, and 22 healthy individuals. PBMCs were isolated, and RNAs were extracted and synthesized into cDNAs. Genes expression was evaluated using the Real-Time PCR method.Results: Our study revealed a decrease in GARP expression in both CD and IBD groups. We also found that the expression of MALAT1 and miR-142-3-p were elevated in CD and IBD groups, contributing to the observed decrease in GARP levels. It also has been discovered that smoking is associated with an increase in MALAT1 expression in all patients.Conclusion: Our research indicates that changes in GARP, MALAT1, and miR-142-3-p levels may be the culprit behind the reduction in TGF-β levels. Moreover, an increase in MALAT1 and miR-142-3-p expression could be responsible for a decrease in GARP levels. These novel biomarkers provide a deeper understanding of the pathways involved in the pathogenesis of IBD and may pave the way for the development of innovative diagnostic or therapeutic approaches.
Ceftriaxone has a neuroprotective effect in a whole brain irradiation-induced neurotoxicity model by increasing GLT-1 and reducing oxidative stress
Authors: ÇİNİ Nilsu , ATASOY Özüm Büke , Uyanıkgil Yiğit , YAPRAK Gökhan , Erbaş Oytun
Published: June 2023

Background: Radiation-induced brain injury is an evident side effect of brain irradiation (IR). Often leads to severe and debilitating cognitive dysfunction and neuronal damage. Ionizing radiation results in oxidative and inflammatory processes. Radiation-induced cognitive impairments are also associated with alterations in glutamate composition. Increased release or decreased uptake of glutamate results in dysregulation of neuronal homeostasis, leading to oxidative stress, mitochondrial dysfunctions, and neuroinflammation.
Materials and Methods: Twenty-one rats were taken in the study, and 14 of underwent whole brain IR with a 20 Gray single dose. Ceftriaxone (CTX) treatment was applied in addition to the IR, for 15 days. Animals were divided into three groups. Group1:Normal control; Group2:Placebo(IR-only), Group3:IR+CTX. The one-way ANOVA statistical test was used to compare groups. The value of p<0.05 was accepted as statistically significant.
Results: In addition to the IR applied CTX treatment exhibited a positive impact on the results of the three-chamber sociability test, open field test and passive avoidance learning test, hippocampal CA1, CA3, and Purkinje neuron counts, brain levels of brain-derived neurotrophic factor, Glutamate transporter-1 and Superoxide dismutases activity. As well, CTX decreased the glial fibrillary acidic protein immunostaining index and brain levels of malondialdehyde and tumor necrosis factor-alpha.
Conclusion: Ceftriaxone represented a promising effectiveness on radiation-induced neurocognitive impairments and degradation of social-memory capacity by reducing neuronal loss, oxidative stress, and neuroinflammation in the brain. Also, CTX application induces scavenging of glutamate from the synapses helps to prevent glutamate excitotoxicity, and protects neurons from excitotoxic cell death.
Conservation of Native Tree Species in The Agroforest of Rice-Based Agroecosystems Will Contribute to The Sustainable Agriculture
Authors: Lopus Merlin , Jaiswal Deepak , Shakeela V , Reshma D , Shafi Subaiba , Habeeb Abdulla , Kushwaha Amit
Published: June 2023

Traditional agriculture relies on ecosystem services for sustainable food production and is also identified as a climate-smart approach. The present study analyses the agroforests associated with the rice farming system of three different agricultural practices for biodiversity richness by comparing two parameters: plants and birds. Out of the 9 study sites, 3 sites were traditional farms maintained by Kurichiya tribal communities, 3 were natural farms, and the other 3 farms were modern. A total of 45 families, 104 genera, 128 species of plants, and 101 bird species belonged to 48 families, and 17 orders were identified from the study sites. The sample-size-based rarefaction and extrapolation (R/E) method was adopted to identify estimated biodiversity indices. Renyi profile was used to understand the native tree diversity profile of the selected sites. The result of this study indicates that bird diversity is positively correlated with native tree diversity and NDVI of May and October. Conserving more native trees in the farmland could be one of the reasons for the sustainable agriculture system of the Kurichiya tribal community as it attracts more bird species and contributes to the biological control of pests. Thus, the conservation of native tree species in the agroforest of rice-based agroecosystems will contribute to the sustainable agriculture system.
Analogue of Ramanujan's function k(τ) for the continued fraction of order six
Authors: Guadalupe Russelle , Aricheta Victor Manuel
Published: June 2023

We study the modularity of the function $w(\tau) := X(\tau)X(3\tau)$, where $X(\tau)$ is the continued fraction of order six introduced by Vasuki et. al (2010). The function $w(\tau)$ is an analogue of Ramanujan's function $k(\tau)=r(\tau)r(2\tau)^2$, where $r(\tau)$ is the Rogers-Ramanujan continued fraction. We prove that $w(\tau)$ is an $\eta$-quotient that generates the field of all modular functions on the congruence subgroup $\Gamma_0(18)$, and express $X(\tau)$ and $X(3\tau)$ in terms of $w(\tau)$. We also show that there is a modular equation for $w(\tau)$ for all positive integers $n$, and provide explicitly the modular equations of level $p$ for primes $p\leq 13$. We finally show that $w(\frac{\tau}{3})$ generates the ray class field $K_{(3)}$ over an imaginary quadratic field $K$ modulo $3$ for some suitable $\tau\in K$.
Modelling and simulation of the contour error evaluation based on spherically-approximated patches for freeform surface
Authors: Fan Wei , Min Kang , Dai Houfu , Su Zhiwei
Published: June 2023

The mathematical modelling of contour error evaluation in Computer Aided Manufacture (CAM) system is critical for high-precision measurement and manufacture of free-form surface. The existing methods of evaluating the contour errorfor free-form surface have been developed based on various models. Nevertheless, there still exist some of the shortcomings when applied practically, including the inaccurate distance model between the measured point cloud (MPC) and ideal surface, numerical search required for the correspondence, possible local optimum of solution, the inapplicability to all the surfaces, the huge point cloud required, and heavy computational load in the registration iteration, and so forth. Toovercome those shortcomings, this work proposes the spherically-approximated patch (SAP) registrationmethod for the contour error evaluation of free-form surface. The significance of registration between MPC and the SAP set is theoretically analyzed. The SAP set for the ideal surface is efficiently generated based on the centroid-midpoint search of parametric triangle subdivision (CMSPTS). And the tactics of efficiently computing the shortest distance from the MPC to the SAP set based on a local spreading search function (LSSF) is provided. Finally, the scheme of evaluating contour error based on the Point-To-SAP (PTSAP) registration is developed. The comparative simulation and experiment demonstrate that the proposed method raises the registration level between MPC and the ideal surface and produces the evaluation result closer to the theoretical one with an acceptable efficiency, and reduces the size of ideal point cloud compared with the existing methods.
HUBUNGAN PENGELUARAN KONSUMSI RUMAH TANGGA, PENGELUARAN KONSUMSI PEMERINTAH DAN PAJAK DAERAH TERHADAP INDEKS PEMBANGUNAN MANUSIA (IPM) DI KABUPATEN TULUNGAGUNG TAHUN 2011-2020
Authors: Hanggarany Pramodya
Published: June 2023

Riset ini bermaksud menganalisa akibat dari pengeluaran konsumsi rumah tangga, serta konsumsi pemerintah serta pajak wilayah kepada indeks pembangunan manusia( IPM) di Kabupaten Tulungagung tahun 2011- 2020. Penerangan pada pada riset ini ialah informasi inferior yang berawal dari Badan Pusat Statistik (BPS) yang mencakup pengeluaran konsumsi rumah tangga, pengeluaran konsumsi pemerintah serta pajak wilayah di Kabupaten Tulungagung. Riset ini memakai cara kuantitatif dengan metode analisa informasi yang dipakai merupakan regresi linier berganda memakai SPSS 23. Hasil riset ini membuktikan kalau: (1) pengeluaran mengkonsumsi rumah tangga mempengaruhi positif kepada indikator pembangunan orang di Kabupaten Tulungagung (2) pengeluaran mengkonsumsi penguasa tidak mempengaruhi penting kepada indikator pembangunan orang di Kabupaten Tulungagung (3) pajak wilayah tidak mempengaruhi penting kepada indikator pembangunan orang di Kabupaten Tulungagung (4) pengeluaran mengkonsumsi rumah tangga, pengeluaran mengkonsumsi penguasa serta pajak wilayah bergengaruh positif kepada indikator pembangunan orang di Kabupaten Tulungagung tahun 2011- 2020.
Using ACER ConQuest program to examine multidimensional and many-facet models
Authors: KOYUNCU Mahmut Sami , ŞATA Mehmet
Published: June 2023

The main aim of this study was to introduce the ConQuest program, which is used in the analysis of multivariate and multidimensional data structures, and to show its applications on example data structures. To achieve this goal, a basic research approach was applied. Thus, how to use the ConQuest program and how to prepare the data set for analysis were explained step by step. Then, two example applications were made considering the multidimensional structures. Finally, different sources of variability (e.g., item, student, rater, gender), which are both multidimensional and independent of each other, were performed by considering different sources of variability together. According to the analyses, the dimensionality of the data structures must be examined in the analysis process. If the data structure is multidimensional, appropriate multidimensional IRT analyses should be performed.
Demystifying the Concept of the Right to Health
Authors: Nedić Tomislav
Published: June 2023

U realitetu rapidnoga opće-društvenog razvoja, pojavom pitanja o novim nositeljima subjektivnih prava te prodiranjem novih oblika (subjektivnih) prava općenito, rasprava o moralnim i subjektivnim (pravnim) pravima oduvijek je bila, jest i biti će aktualna društvena komponenta. Neosporno je kako pravo i (humana) bioetika primarno vlastitu usredotočenost temelje zaštiti ljudskoga života i ozbiljenju vrhovnosti ljudskoga zdravlja. Postizanje cjelokupne ljudske dobrobiti nedvojbeno je uvjetovano imanentnošću dobroga zdravlja, a u suvremenome ga društvu omogućava jedinstveni »mehanizam« – pravo na zdravlje. Iako usredotočena kulturi zdravlja (healthism), trenutna epoha oksimoronski prostire seriju izazova i kontroverzi vezanih uz pitanje ljudskoga zdravlja i njegovoga očuvanja koja su osobito došla do izražaja tijekom COVID-19 krize. No apriorno pitanje koje se može postaviti jest – što bi to samo zdravlje uopće bilo? Upravo zato zaštita ljudskoga zdravlja i ostvarivanje prava na zdravlje jedno je od najzahtjevnijih problematika s kojim se pravo (u objektivnom smislu) može susresti. Pravo na zdravlje, kao subjektivno i prilično inkluzivno pravo, utjelovljuje ne samo prava koja su antropocentrički orijentirana, već i ona prava koja teže biocentričkoj zaštiti harmonije ravnoteže okoliša i prirode kao neodvojivih nazivnika stanja ljudskoga zdravlja. Iako su istaknuti (uglavnom anglosaksonski) politički i pravni filozofi bili pesimistični glede ostvarivanja i provedbe prava na (najviši dosežni standard) zdravlja, u ovome se radu nude mogućnosti njegova ostvarivanja, koje uvelike ovise o tome na koji se način koncept zdravlja uopće shvaća. Zdravlje bi trebalo biti razmatrano u vidu idejno-vrijednosne kategorije kojoj se teži (Sollen), bez umišljaja o čistoj i kategoričkoj refleksiji zbilje (Sein). S obzirom na inkluzivnost specifičnu za pravo na zdravlje, u ovome se radu nudi obradba i razmatranje prava na zdravlje u njegovoj pojmovnoj te normativnoj cjelini i opsegu polazeći od pitanja: kako pravo štiti ljudsko zdravlje i njegove konstitutivne elemente? Isto pitanje izaziva zanimljiva interdisciplinarna (prvenstveno pravna i filozofijska) gledišta.
A Contribution to the Bioethicisation of Paulo Freire’s Philosophy of Education
Authors: Guć Josip
Published: June 2023

U ovom se radu pokušava ukazati na misli Paula Freirea koje bi mogle biti plodne u kontekstu bioetičkog razmatranja odnosa čovjeka spram prirode, tj. ne-ljudskih živih bića, poglavito s obzirom na razvoj bioetičkog senzibiliteta, posebice prisutnog kod djece. S obzirom na to da izvjesne osobine, kompatibilne s idejom bioetičkog senzibiliteta, pripadne djetinjstvu sačinjavaju srž Freireove filozofije odgoja, radi se o području u kojem bioeticizacija Freireove misli može biti osobito plodna. Pored toga, u radu se iznose i njegovi stavovi koji idu u smjeru moralne obzirnosti spram ne-ljudskih živih bića, kao i oni koji su ovima donekle kontradiktorni, s obzirom na to da pružaju osiromašene uvide u bogatstvo samoostvarivanja ne-ljudskih živih bića. Prije ovih razmatranja, dodatno se razjašnjava pojam bioeticizacije filozofije, posebice s obzirom na blisko vezan (programatski) pojam europeizacije bioetike. Oba se ova pojma koriste u kontekstu integrativne bioetike. U posljednjem se poglavlju pojašnjava potencijalni doprinos Freireove dijaloške metode razvitku pluriperspektivističke metodologije integrativne bioetike.
QUEST FOR ISOLATION AND IDENTIFICATION OF PLASTIC DEGRADINGMICROORGANISMS: A MOLECULARAPPROACH
Authors:   Department of Biotechnology, M.Sc., Guru Nanak Institute of Pharmaceutical Science and Technology, Kolkata, West Bengal, India., Das Mou , Chakraborty Tamalika ,   Department of Biotechnology, Assistant Professor, Guru Nanak Institute of Pharmaceutical Science and Technology, Kolkata, West Bengal, India.
Published: June 2023

Microorganisms havea very essential role in the biological breakdown of various organic matter in the natural environment, this process is known as biodegradation. Polyethylene waste and plastics from synthetic materials accumulate in the environment and represent a growing ecological threat. Biotic and abiotic methods have been used to turn polymers into monomers. This issue might be resolved by powerful microbial strains (robust) and the biodegradation of this plastic trash. In this study, in vitro, the biodegradation of polyethylene and PVC tapes was analyzed using microorganisms isolated from the soil after an incubation period of one month. Microbial species associated with degradation ability were identified as Gram-positive bacteria and Gram-negative bacteria. In the future, microbial-friendly plastics are safe for the environment and can reduce plastic waste on the environment Further research is underway and it will have good applications in the future due to its low cost and eco-friendly properties.
MOROCCAN WOMENS EMPOWERMENT THROUGH THE USE OFAN MHEALTH SOLUTION FOR FERTILITY MANAGEMENT AND CONTRACEPTION:
Authors:   Maternity Les Orangers Hospital, Rabat, Morocco., Tijani MD Najlaa , Alami Hassan ,   Maternity Les Orangers Hospital, Rabat, Morocco., Idri Ali ,   Software Project Management Research Team, Department of Web and Mobile Engineering, ENSIAS, Mohamed V University. Rabat, Morocco., Bezad Rachid ,   Maternity Les Orangers Hospital, Rabat, Morocco.
Published: June 2023

In developing countries, limited access to family planning services, results in high rates of unintendedpregnancies and unsafe abortions leading to many avoidable maternal deaths.Unmet need for family planning Â«UMNÂ»is one of the United NationsMillennium Development Goals Indicators? it evaluates women who are fecund and sexually active but are not using any methods of contraception, while reporting not desiring any more children or wanting to delay the next child. According to the Moroccan national survey for family planning published in 2018,the unmet need for family planningwas 29.2% which is high.The advent of new technological solutions created for family planning has the potential to address unmet needs in low- and middle-income countries.In Morocco, research studies are scarce in the field of Family planning and sexual health.To improve the access to family planning methods and to lower the perceived barriers to contraception use in Morocco, our team in Maternity les Orangers collaborated with the software research team of the national school for computer science ENSIAS in a research project to create a new mHealth solution tailored to Moroccan women, to help empower them to achieve their reproductive goals and contraceptive needs.
PERCEPTION OF SELF-MEDICATION AMONG TAIBA UNIVERSITY STUDENTS, SAUDI ARABIA
Authors:   Joint Program of Preventive Medicine Post Graduate Studies, Ministry of Health, Al Madinah Al Munnawarah, Saudi Arabia., Majdi Tolah Khaled , Ghallab Alamri Abdulmajeed ,   Joint Program of Preventive Medicine Post Graduate Studies, Ministry of Health, Al Madinah Al Munnawarah, Saudi Arabia., Salman Almohammedi Yasser ,   Joint Program of Preventive Medicine Post Graduate Studies, Ministry of Health, Al Madinah Al Munnawarah, Saudi Arabia., Abdulrahman Kurban Azhar ,   Department of ENT, King Salman Medical City, Ministry of Health (MOH), Al Madinah Al Munnawarah, Saudi Arabia., Majdi Tolah Meeral ,   Department of General Biology, Faculty of Science, Taibah University, Al Madinah Al Munnawarah, Saudi Arabia., Ahmed Salem Khadega ,   Joint Program of Preventive Medicine Post Graduate Studies, Ministry of Health, Al Madinah Al Munnawarah, Saudi Arabia., Majdi Tolah Ahmed ,   Department of Medical Laboratory Technology, Faculty of Applied Medical Science, King Abdulaziz University, Rabigh 344, Saudi Arabia.,   Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21362, Saudi Arabia., Abdo Radman Al-Dubai Sami ,   Joint Program of Preventive Medicine Post Graduate Studies, Ministry of Health, Al Madinah Al Munnawarah, Saudi Arabia.
Published: June 2023

Self-medication refers to the practice of treating oneself with medication without consulting a healthcare professional. This practice can be dangerous to health. This study aimed to assess the practice of self-medications and associated factors among students in Taiba University, Saudi Arabia. Across sectional study was employed to investigate the practice of self-medications among 210 students in Taiba University by using a self-administered questionnaire.Among all respondents, 87.1% practiced self-medication at least one medication in the last year. The most common self-medication was pain killers (80%) and the most common indication of use was headache (75%). Reasons of self-medication practices were previous experience (52.9%) and no serious health symptoms (51.0%). The most common source of information was personal knowledge (51.0%). The prevalence of elf-medication practice was 87.1%. The most common self-medication was pain killers while, the most common indication of self-medication was headache. The most common reason for self-medication practices was previous experience, and the most common source of information was personal knowledge. Males practiced self-medications more than females.
MARKETING MANAGEMENT OF COMMUNITY PRODUCTS FOR HEALTH TOURISM IN RANONG PROVINCE, THAILAND
Authors:   LecturerDr., College of Innovation and Management, SuanSunandhaRajabhat University, Thailand., Buddhapoompitak Wannaporn , Kanchanathaveekul Kanyamon ,   Associate Professor Dr., College of Innovation and Management, SuanSunandhaRajabhat University, Thailand., Saengon Poramet ,   Assistant Professor Dr., College of Innovation and Management, SuanSunandhaRajabhat University, Thailand., Siriyanun Sirinya ,   LecturerDr., College of Innovation and Management, SuanSunandhaRajabhat University, Thailand., Sungrugsa Narin ,   Professor Ph.D., Faculty of Management Science, Silpakorn University, Thailand., Boonkoum Wannawee ,   Assistant Professor Ph.D., Faculty of Management Science, Silpakorn University, Thailand.
Published: June 2023

The purpose of this research was to analyze the management approaches for the marketing channels of community goods and Health tourism in Ranong Province, Thailand. Quantitative method was conducted by interviewing 30 samples who own restaurants, gift shops, and health tourism enterprises. The technique used in this study was an in-depth interview with local business company owners and the collected data were written in the form of content analysis. The research results showed that young individuals with potential for marketing, notably via social media, are the group leaders of Ranong Cocoa Community Enterprises, and they make use of cocoa mass, a product manufactured from 100% of the cocoa beans that are the main components used to make chocolate through creating a Facebook page, and networking with other company owners. In addition, there are other products available, for examples, cocoa nibs and tea produced from cocoa husks, and packaged cocoa tea that is prepared to be consumed. It is a prototype product that may also be manufactured commercially. Additionally, the cacao.cocoa.drink@gmail.com and YouTube websites are part of the Ranong Cocoa Community Enterprise\'s marketing channel management plan for its products.
Access to public information regarding laboratory animals: law and ethics
Authors: DZIKOWSKI ANDRZEJ
Published: June 2023

Normative regulations concerning the use of animals in experiments and education raise numerous controversies and much social discussion. One of the aspects of implementing this form of social activity is the use of constitutional, subjective right of access to public information. Competent public administration authorities, and administrative courts encounter numerous difficulties related to requests for information. Attempts to assess, evaluate, and verify whether the applicants’ goals and intentions are consistent with the axiological premises of the statutory norms occur. The study reveals veterinary, legal, and moral aspects of requests for access to public information related to the use of animals in testing and teaching procedures. The controversial concept of abuse/misuse of the subjective right to access information is presented in a critical, multifaceted way. Obligations of professional ethics of veterinary surgeons concerning laboratory animals and public information related to them are discussed. The effectiveness and consistency of normative regulations are assessed. Interpretational postulates are indicated.
O processo deliberativo no Conselho Nacional de Assistência Social: uma análise da influência e estratégias de stakeholders
Authors: Santana Aline Farias de , Vieira Diego , Almeida Lia de Azevedo
Published: June 2023

Este trabalho busca compreender as relações de poder na formulação de políticas públicas a partir de uma perspectiva crítica. Nesse sentido, o objetivo é analisar de que forma os stakeholders influenciam o processo de tomada de decisão no Conselho Nacional de Assistência Social (CNAS), considerando os papéis institucionais que exercem e suas estratégias de discurso. Especificamente, analisou-se a atuação dos stakeholders relativos ao Benefício de Prestação Continuada, com amparo na Teoria de Stakeholders e na Análise de Discurso Crítica. O corpus da pesquisa foi composto por documentos das degravações de audiências públicas, de seis entrevistas com conselheiros e ex-conselheiros, além da observação não participante no âmbito do CNAS. Os dados foram submetidos à análise de conteúdo e Análise de Discurso Crítica. Os stakeholders que exerceram influência foram classificados em dois grupos: os empreendedores e os conciliadores políticos. Estes últimos utilizaram estratégias típicas de construção simbólica, como a racionalização e a simbolização de unidade. Este grupo demonstrou conhecimento técnico ao justificar as escolhas que eram tomadas em torno de mudanças de escopo do benefício. Já os empreendedores políticos destacaram-se pelo emprego da estratégia expurgo do outro, a qual foi utilizada enfaticamente ao tratar os conciliadores como inimigos perigosos.
UTILIZAÇÃO DE MODELOS IN SILICO PARA AVALIAÇÃO DA TOXICIDADE DE RESÍDUOS DE AGROTÓXICOS, FÁRMACOS E METABÓLITOS EM ÁGUAS NATURAIS
Authors: Alves Marcelo , Streit Lívia , Pizzolato Tânia
Published: June 2023

WORKFLOW OF IN SILICO MODELS TO EVALUATE THE TOXICITY OF PESTICIDE RESIDUES, DRUGS AND METABOLITES IN NATURAL WATERS. Constantly we have to deal with an exponential increase in the amount of different chemical compounds that industries synthesize and manufacture, such as drugs, pesticides, persistent organic pollutants, preservatives, and personal hygiene products. Many of these chemical substances are biologically active and interact with biomolecules, such as proteins, through specific mechanisms that lead to different biological responses. Due to the inherent risk of many compounds to the environment and to humans, their toxicological activities must be evaluated. In order to evaluate the biological activity of molecules, three types of experiments can be used: in vivo (e.g., animal tests); in vitro (e.g., cell tissue culture); and in silico simulations. In vivo and in vitro experiments are time-consuming and expensive processes, in addition to causing ethical discussions and debates. An alternative to avoid these setbacks is the use of in silico models. The scientific community thus begins to use in silico models as a possible alternative, developing a large number of models and strategies capable of predicting the toxicological properties of several chemical compounds. This review discusses methods that employ in silico models to assess and predict the possible effects of contaminants found in natural waters.
Imperial Russia as a Failed State: The Role of Orthodox Church
Authors:   Brandeis University, Freeze Gregory L.
Published: June 2023

The purpose of this article is to assess the role of the Orthodox Church during the prelude to the February Revolution. Recent historiography on the Great War in Western scholarship has foregrounded the role of the Churches, Protestant and Catholic, in sustaining popular support for a war that entailed unprecedented death, suffering, and hardship. That new research, seeking to explain the “endurance problem” (Durchhaltsproblem), point to the Churches in the West as the pillar of the existing regimes right to the very end of the war and as an effective instrument in mobilizing support and patriotism to defend each country’s “civilization”. Hence, no less important than brilliant military plans and effective governance, the Churches provided critical support and raised morale of both troops and civilians. Such was not the case in Russia. With few resources at its disposal, the Orthodox Church provided initial but ephemeral support. As is shown here, the Church was not only unable but unwilling to embrace the ancient regime: against a background of general war weariness, the Church elites, parish clergy, and ordinary parishioners were increasingly determined to pursue their own interests, not those of the state. By February 1917 the Church did not condemn but welcomed the overthrow of the monarchy that ultimately led to the Bolshevik seizure of power and years of brutal civil war. The monograph by I. V. Potkina “On the eve of the catastrophe. The state and the economy in Russia in 1914–1917” has many positive elements, but it is important — given recent historiography, which foregrounds the role of Churches and religion in sustaining society’s willingness to endure the Great War — to pay attention to the role of the Russian Orthodox Church.
The Varangian Issue through the Prism of the Social Contract Concept
Authors:   Omsk State Pedagogical University, Vtorushin Mikhail I.
Published: June 2023

The article is devoted to an under-researched topic of the impactth at the theory of the social contract of European thinkers of the 17th–18th had on the discussion in the 18th-century Russia on the “Varangian-Russian issue”, the conditions and basis for the East Slavs’ state-building in the initial period. It gives a proper analysis of socio-political and economic factors for accepting the doctrine of G. Grotious, T. Gobbs, J. Locke, B. Spinoza, and Ch. Montesquieu by Russian nobility. The doctrine described the treaty-based relations between the State of Russia and its sovereigns. The article studies the influence of the Social Contract theory on the Tsarism’s domestic policy in the second half of the 18th century. This policy was upheld in the form of the Enlightened absolutism which served to balance the interests of the upper classes of the Russian Empire. By examining the views on the “Varangian issue” of members of the Russian Academy of Science, such as G. Bayer, G. Miller, and M. Lomonosov, the article explores the effect of the treaty-based concept of the state on the views on the genesis of the Russian statehood and the rejection of the theological doctrine of the sovereignty in the country. Historians G. Bayer and G. Miller accepted the conclusions of the European thought on the origin of state-building in some European nations as a result of an external conquest or an agreement for managing. Using the chronicle about the invitation of a Varangian Rurik, they revealed a similar process in Russia. A different viewpoint was expressed by M. Lomonosov. He considered the Slavs’ statehood and the conclusion of the management agreement to be the result of their internal development.