bluuebunny/crossref_metadata_2025 huggingface dataset:
Research Efficiency Analysis of Universities in 31 Chinese Provinces Using Three-Stage DEA Model and Dynamic Malmquist Index-Based on Provincial Panel Data from 2012 to 2022
Authors: Liang Qingqing , Yin Fang
Published: June 2024

Efficiency serves as a crucial metric in assessing the advancement of scientific research for universities. Reasonable inputs of human resources, finances, materials, and other resources, along with high-quality research output, are important guarantees for the research efficiency of Chinese universities. This study delves into the patterns of changes of research efficiency among universities across the 31 provinces and municipalities of China from 2012 to 2022. By scrutinizing input-output perspectives and utilizing data sourced from the China Statistical Yearbook, the analysis unveils prevailing scenarios of input redundancy and output insufficiency in research efficiency across universities. The static and dynamic trends in research efficiency were further investigated by employing a static non-parametric Data Envelopment Analysis (DEA)-BCC model and a dynamic Malmquist index. Key findings from the analysis from 2012 to 2022 include: (1) notable growth in investments in teaching, research equipment assets, and research and development funds among nationwide universities; (2) a steady increase in the mean value of technical efficiency (TE) from 0.97 to 0.99, indicating continuous enhancement in overall efficiency in research input resource allocation across the provinces; (3) the mean Malmquist productivity index of 1.285, with an average annual increase of 28.5%, signifying a consistent improvement in university research efficiency throughout the study period; and (4) the provinces experiencing varying degrees of input redundancy or output insufficiency were selected to suggest the need for tailored strategies in resource allocation. The study underscores the importance of a holistic evaluation system involving stakeholders from government, universities, and society to optimize research efficiency and promote scientific innovation and social development.
Prevalence of Low Back Pain in Portuguese Equestrian Riders
Authors: Duarte Carlota , Santos Rute , Fernandes Orlando , Raimundo Armando
Published: June 2024

Low back pain is prevalent in equestrian athletes, but prevalence and associated factors are unknown in the Portuguese equestrian population. A questionnaire regarding low back pain and possible associated factors was answered by 347 respondents. Estimated 12-month prevalence was 67.1%. The probability of suffering from low back pain was higher in individuals with higher weekly riding workload, that reported equestrianism as their main occupation and that performed daily stable duties. The Roland Morris disability questionnaire was applied to the respondents that stated having experienced low back pain in the past 12 months, resulting in an average score of 5.39 ± 4.42. 63.1% of respondents stated that low back pain impaired their performance. Individuals that stated equestrianism was their main occupation showed a significant higher risk (OR = 1.759) of exhibiting a score ≥ 4, as measure of dysfunctionality. Age and high body mass index were also associated to a dysfunctional score. Further research is needed to fully understand the impacts of low back pain in Portuguese equestrian athletes.
Influential Elements Influencing How Consumers Behave when Purchasing Organic Farm Products
Authors: Azizi Jafar , Vahabi Sorood Marzieh , Mohammadinejad Amir
Published: June 2024

The principal aim of this descriptive-survey investigation is to ascertain the factors influencing individuals' choice to purchase organic commodities in Tehran. The statistical populace for this examination comprised all patrons of food retail establishments in Tehran, with the sample size determined using the Cochran formula for an unknown community size, involving the distribution of 30 questionnaires to customers (n=439). Data collection was carried out through a random sampling technique. The survey instrument consisted of a questionnaire with two sections consisting of general queries (7 questions) and specific inquiries (23 items) categorized into four dimensions (product, price, place, and promotion) for the clientele. The questionnaire's validity was confirmed through face and content validation, while its reliability was assessed utilizing Cronbach’s alpha. Data analysis was conducted using SPSS25 software, encompassing both descriptive and inferential statistical analyses. The results revealed a positive and significant correlation between customers' inclination to consume organic goods and the characteristics of the product, price, and promotion. However, no association was found between the propensity to consume organic products and location characteristics. Concerning contextual variables, a solely positive and significant correlation was identified between the willingness to purchase organic items and consumer income levels. No significant relationships were detected between other contextual variables and organic product consumption. A notable contrast was observed between respondents' gender and their readiness to buy organic products, while no significant variances were noted regarding age, income, occupation, and education in relation to the propensity to purchase organic commodities.
Suppression of Metastasis of Colon Cancer to Liver by Pretreatment With Extracellular Vesicles Derived From Nanog-Overexpressing Colon Cancer Cells
Authors: Henmi Takuya , Matsuoka Hideaki , Saito Mikako
Published: June 2024

It has been demonstrated that cancer cells that have survived cancer treatment may be more malignant than the original cancer cells. These cells are considered to be the main cause of metastasis in prognosis. A Nanog-overexpressing colon-26 (Nanog+colon26) was generated and its metastatic potential was confirmed to be enhanced, indicating higher malignancy. Extracellular vesicles (EVs) secreted from the cell line (Nanog+colon26EVs) were administered to mice at 5 μg nine times (three times per week for three weeks) via the tail vein (PBS was used as a control). Subsequently, Nanog+colon26 cells were administered to mice via the spleen, and the quantity of metastatic colonies in the liver was analyzed two weeks later. The results demonstrated that the administration of EVs suppressed metastasis. The enhanced phagocytic activity of macrophages observed in the group treated with Nanog+colon26EVs indicated the involvement of the immune system in the observed metastasis-suppressing effect. Small RNA sequencing was conducted to identify Nanog-dependent miRNAs that exhibited significant changes (Fc>=1.5 or Fc
Brain Metastases from Thyroid Carcinoma: Prognostic Factors and Outcome
Authors: Esmaeilzadeh Majid , Atallah Oday , Müller Jörg Andreas , Bengel Frank , Polemikos Manolis , Heissler Hans E , Krauss Joachim K
Published: June 2024

Intracranial metastases from thyroid cancer are rare. Although the prognosis of thyroid cancer patients is generally favorable, the prognosis of patients with intracranial metastases from thyroid cancer has been considered unfavorable having a lower survival rate than those without intracranial involvement. Many questions about their management remain unclear. The aim of this study was to analyze the characteristics, treatments, and outcomes of patients with brain metastases from thyroid cancer. Among 4320 patients with thyroid cancer recorded in our institutional database over a 30-year period, 20 patients with brain metastasis were retrospectively collected and analyzed. The clinical characteristics, histological type of primary cancer and metastatic brain tumor, additional previous distant metastasis, treatment modalities, locations and characteristics on radiologic findings, time interval between the first diagnosis of the primary thyroid cancer and brain metastasis, and survival were analyzed. The mean age at initial diagnosis was 59.3 ± 14.1 years, and at the manifestation of diagnosis of cerebral metastasis 64.8 ± 14.9 years. The histological types of the primary thyroid cancers were papillary in ten patients, follicular in seven, and poorly differentiated carcinoma in three. The average interval between the diagnosis of thyroid cancer and brain metastasis was 63.4 ± 58.4 months (range, 0-180 months). Ten patients had a single intracranial lesion and 10 patients had multiple lesions. Surgical resection was primarily performed in 15 patients and whole-brain radiotherapy, radiotherapy or tyrosine kinase inhibitors were applied in the other 5 patients. Overall median survival time was 15 months after diagnosis of BM from TC (range: 1-252 months). Patients with thyroid cancer can develop brain metastasis even many years after diagnosis of the primary tumor. Our study demonstrates an increased overall survival of patients younger than 60 years of age at the time of diagnosis of brain metastasis. There was no difference in survival between patients with brain metastasis from papillary or follicular thyroid carcinoma.
Exploring the Influence of Sociocultural Factors on Non Utilization of Family Planning amongst Women in Ethiopia's Pastoralist Regions
Authors: Muluneh Muluken Dessalegn , Kidane Woldu , Stulz Virginia , Ayele Mhiret , Abebe Sintayehu , Rossetti Andrea , Amenu Gedefaw , Ayehu Azmeraw , Berhan Makida
Published: June 2024

This study aimed to explore the sociocultural determinants of family planning (FP) utilization among women in pastoralist areas of Ethiopia. A community based cross-sectional survey was conducted involving 682 re-productive aged women selected from three regions in pastoralist districts. Hierarchical logistic regression was used to identify factors associated with women who did not use FP. This study revealed that 47% of women did not use FP. Women who did not use FP were more likely to shorter spaces between births, lack of partners’ support, when only a husband or someone else decides on large household purchases, and low use of household expenditure were some of the factors associated with not using FP. Overall, the prevalence of not using FP is significantly high in pastoralist communities of Ethiopia. The authors recommend that investment in women’s health and FP be targeted at educational campaigns to raise awareness about FP and its importance. Engaging men and community leaders, promoting their support for FP and contraceptive use, and providing financial assistance to address financial barriers such as transportation costs and healthcare fees, are important aspects that can increase the utilization of FP methods.
Improving Remote Monitoring of Carbon Stock in Tropical Forests Using Machine Learning: A Case Study in Indonesian Borneo
Authors: Chamberlin Andrew J. , Liu Zac Yung-Chun , Cross Christopher G.L. , Pourtois Julie , Siregar Iskandar Zulkarnaen , Nurrochmat Dodik Ridho , Setiawan Yudi , Webb Kinari , Hopkins Skylar , Sokolow Susanne H. , De Leo Giulio A.
Published: June 2024

Deforestation through land-use conversion, illegal logging, and timber trafficking is believed to cause ~10% of the annual human carbon dioxide emissions at the global level. Given the large contribution, local and national policies have been set in place in the effort to reduce deforestation and support reforestation. However, accurate assessment of forest carbon stock is expensive and challenging in remote areas and on large geographical scales. To improve carbon stock monitoring and evaluation of fine-scale forest loss, we developed a rapid, automatic, scalable, and cost-efficient generalized deep learning framework that uses diverse remote sensing data and satellite imagery to derive aboveground carbon density from accurate estimates of tree canopy heights at fine-grained resolution (30x30 meters) in remote tropical rainforests. The remote sensing data is composed of Landsat-8, Sentinel-1, land cover, digital elevation model, and NASA CMS airborne LiDAR, as well as vegetation indices, texture metrics, and climatic data. Data sources were compiled into a data pipeline which produced >300 features and 2 million observations over forests in Indonesian Borneo. Using LiDAR swath data on canopy forest high for ~100,000 hectares in Indonesian Borneo to create a training and validation datasets, our neural network model produced aboveground carbon density estimates with R2 of 0.82, which is a significant improvement from comparable works by using Random Forest (R2 of 0.3-0.5). This deep learning framework can be used to facilitate further carbon stock modeling in other forest regions (e.g., Brazil) as well as for the general purpose of climate change mitigation.
STRATEGI PENGEMBANGAN EKOWISATA MELALUI KONSEP COMMUNITY BASED TOURISM (CBT) DALAM UPAYA MENINGKATKAN PEREKONOMIAN MASYARAKAT (STUDI KASUS: DESA PENDEM, KECAMATAN MOJOGEDANG)
Authors: Purnomo Candrawati Putri , Nugraha Setya , Tjahjono Gentur Adi
Published: June 2024

Pendem Village is one of the villages in Mojogedang District, Karangnyar Regency which is rich in potential natural resources that can be used as tourist areas Ecotourism is one of the activities in sustainable tourism that utilizes tourism activities to develop environmental conservation through education and changes in community behavior. The research method used in this study is a quantitative method with a descriptive approach. The data collection used in this study was field observation and interviews. The results in the study show the level of land suitability of all ecotourism objects in Pendem Village is included in the Quite Suitable (S2) class. The community-based ecotourism potential assessment in Pendem Village is divided into 2 classes, namely Sendang Bulu is included in the Very Potential class while Toya Wening, Jamu Education, Biogas Education and Bukit Penthuk are included in the potential class. The community-based ecotourism development strategy using SWOT analysis of 5 ecotourism objects obtained by S-T (Strengths-Threats) is suitable to be applied to Sendang Bulu and Toya Wening Objects, because both objects are potential objects but require efforts by diversifying strategies in facing future challenges. The S-O (Strength-Opportunities) strategy is suitable to be applied to the objects of Herbal Medicine Education and Biogas Education. While the other object, Penthuk Hill, is suitable to apply the W-O (Weaknesses-Opportunities) strategy, because the object is lacking in terms of facilities and infrastructure such as improving road conditions.
ANALISIS PENGARUH ALIH FUNGSI LAHAN PERTANIAN TERHADAP KETAHANAN PANGAN DI KECAMATAN BAYAN KABUPATEN PURWOREJO TAHUN 2013 DAN TAHUN 2023
Authors: Mahmudah Fitri Tri , Sarwono  , Utomowati Rahning
Published: June 2024

The objectives of this study are (1) To analyze agricultural land conversion the Bayan District in 2013 and 2023. (2) To analyze food security the Bayan District in 2013 and 2022. (3) To analyzing the impact of agricultural land conversion on food security the Bayan District. This research employs a quantitative descriptive method with a spatial approach. Data collection methods involved observation, documentation, and image interpretation. Data analysis techniques used map overlay analysis, calculation of food availability ratio, and paried sample t-test statistical test. The results of this study show that: (1) The conversion of agricultural land (paddy field and moor) the Bayan District in the period 2013 - 2023 is 78.37 hectares (3.11%). (2) Food security the Bayan District in the period 2013 – 2022 averall shows a food surplus condition, this can be seen from the value of food availability ratio that exceeds 1 in each village/sub-district. However, there are 2 villages in 2022 that experience food deficit, these areas are Grantung Village and Pekutan Village. (3) The effect of agricultural land conversion on food security the Bayan District is known from the results of the paired sample t-test statistical test with a Sig value of 0.317, the value is greater than the alpha value of 0.05, therefore, H0 is accepted and H1 is rejected. So it can be concluded that there is no significant effect of agricultural land conversion on food security the Bayan District.
PARTISIPASI PEREMPUAN DALAM PROGRAM KAMPUNG IKLIM (PROKLIM) (Studi Kasus di Dusun Palasari Desa Sukahurip Kecamatan Cihaurbeuti Kabupaten Ciamis)
Authors: Khoiruumah Ilma , Hamdan Ahmad , Laksono Bayu Adi
Published: June 2024

One of Indonesia's current development sectors is climate change control. Program Kampung Iklim  was created, so that communities at the site level can carry out adaptation, mitigation, and institutional actions & sustainable support. Palasari hamlet is a ProKlim hamlet, but has low participation from the female population, so that achieving program sustainability is slightly hampered. The purpose of this study was to determine women's participation in the Program Kampung Iklim. The method used in this research is a case study with data collection through interviews, observation, and documentation. The results showed that women's participation went through 4 stages, (1) women's participation in ProKlim planning, including response participation such as asking questions in socialization activities and participation of tools and materials. (2) Women's participation in the implementation of ProKlim, there is participation of support, there is also participation of expertise and labor. (3) Women's participation in the utilization of ProKlim results, there is an increase in knowledge because it is reflected in the skills in utilizing yard land to improve food security. (4) Women's participation in the evaluation of ProKlim, namely by giving opinions/responses when the activities/programs have been implemented. ProKlim is a series of processes using the principle of empowerment, with the aim of reducing greenhouse gas emissions to create prosperity.
Tareas de cuidado de los menores de 14 años en las parejas de doble proveeduría en México, 2019
Authors: López-Chávez Anabel , Ortiz-Ávila Elsa
Published: June 2024

Mexico is one of the countries where gender inequalities have been recognized, primarily due to the poor distribution of time and domestic caregiving responsibilities between women and men within households. Additionally, there is evident growth in dual-earner couples, replacing the traditional model where the man was the sole provider. Therefore, the aim of this study is to determine if there is greater equality in the allocation of time and caregiving activities for children under 14 in dual-earner couples in Mexico in 2019, through the analysis of time usage and the division of caregiving tasks for children under 14, as well as time spent on paid work. The source of information used to achieve this purpose is the 2019 National Time Use Survey (ENUT, 2019). The results indicate that although women are integrated into the labor market, they actually dedicate nearly the same amount of time to childcare as women who exclusively focus on homemaking, resulting in a double burden of work and persisting inequalities between men and women within households.
Pengaruh Kombinasi Sport Massage dan Deep Tissue Massage Terhadap Ketegangan Otot Ekstremitas Bawah Pada Atlet KOP Karate UNJ
Authors: Apriza Taufiqurahman Akbar , Samsudin  , Setiakarnawijaya Yasep , Yuliana Ela
Published: June 2024

Abstrak. Ketegangan otot merupakan bagian dari gejala Delayed Onset Muscle Soreness (DOMS), dan biasanyan dikeluhkan oleh atlet setelah 12-24 jam melakukan latihan dengan intensitas tinggi. Ketegangan otot dapat diatasi dengan berbagai macam metode salah satunya adalah menggunakan metode sport massage dan deep tissue massage. Penelitian ini bertujuan untuk mengetahui pengaruh kombinasi sport massage dan deep tissue massage terhadap penurunan tingkat ketegangan otot ekstrimitas bawah pada atlet KOP Karate UNJ. Populasi yang digunakan adalah atlet KOP UNJ dan penentuan sampel menggunakan teknik purposive sampling. Sebanyak 15 sampel yang digunakan dan telah memenuhi kriteria sebagai sampel dalam penelitian ini. Metode penelitian ini menggunakan pre-experimental design dengan model one-group pretest-postest design. Pengumpulan data tingkat ketegangan otot menggunakan Numeric Rating Scale (NRS) dan dilakukan sebelum dilakukan perlakuan (pretest) maupun sesudah perlakuan (posttest). Paired Samples t Test digunakan untuk menguji perbedaan perubahan tingkat ketegangan otot ekstremitas bawah 24 jam setelah latihan, dan setelah perlakuan kombinasi sport massage dan deep tissue massage. Hasil penelitian ini menunjukan bahwa, berdasarkan hasil uji hipotesis dengan uji paired samples t-test, diketahui bahwa nilai P value < 0,05. Dengan demikian, dapat disimpulkan bahwa kombinasi sport massage dan deep tissue massage menurunan ketegangan otot ekstremitas bawah yang muncul dari pengaruh latihan.
 
Abstract. Muscle tension is part of the symptoms of Delayed Onset Muscle Soreness (DOMS), and athletes usually complain about it after 12-24 hours of high-intensity exercise. Muscle tension can be treated using various methods, one of which is using sports massage and deep tissue massage. This study aims to determine the effect of a combination of sports massage and deep tissue massage on reducing the level of lower extremity muscle tension in KOP Karate UNJ athletes. The population used was KOP UNJ athletes and the sample was determined using a purposive sampling technique. A total of 15 samples were used and met the criteria as samples in this research. This research method uses pre-experimental design with a one-group pretest-posttest design model. Data collection on muscle tension levels used the Numeric Rating Scale (NRS) and was carried out before treatment (pretest) and after treatment (posttest). Paired Samples t Test was used to test differences in changes in the level of lower extremity muscle tension 24 hours after exercise, and after a combination of sports massage and deep tissue massage. The results of this research show that, based on the results of hypothesis testing using the paired samples t-test, it is known that the P value is <0.05. Thus, it can be concluded that the combination of sports massage and deep tissue massage reduces lower extremity muscle tension that arises from the influence of exercise.
Survei Nervuos Atlet Tenis Meja Ptm Ije-Jela Kab.Barito Kuala Saat Bertanding
Authors: Rifqi Irvannoor  , Kahri Ma’ruful , Rahmadi
Published: June 2024

Pada dasarnya nervous sangat perpengaruh pada pertandingan atlet tersebut, nervous menyebabkan performa atlet tidak maksimal. Maka dari itu artikel ini bertujuan untuk mengenal nervous pada atlet saat bertanding dan untuk memberi pemahamaan mendalam bentuk berbagai tekanan mental yang di alami atlet tenis meja. Manfaat dari penelitian ini ialah untuk mengetahui bentuk nervous apa saja yang pling sering di rasakan oleh atlet tenis meja saat bertanding. responden yang di teliti adalah atlet PTM Ije-jela Kab. Barito Kuala yang berjumlah 20 responden yamg terdiri dari 10 laki-laki dan 10 perempuan. Penelitian ini mengunakan kuisioner yang di bikin melalui google form yang di kirim melalui whatshaap, kemudian di isi oleh responden. Teknik yang di gunakan dalam penelitian ini adalah one survey, yang di maksud dengan one surey ialah penelitian yang di lakukan dalam sekali pengambilan data. Pengolahan data penelitian ini mengunakan excel untuk mendapatkan hasil penelitian. Berdasarkan penelitian ini atlet tenis meja PTM ije-jela Kab.Barito Kuala pengaruh faktor eksternal  sebesar 63 % berada di kategori sedang. Kesimpulan dari penelitian ini ialah faktor Tingkat tekanan mental yang sering di rasakan oleh atlet tenis meja PTM ije-jela Kab.Barito Kuala adalah faktor internal sebesar 70,3 % barada di kategori tinggi. Kesimpulan dari hasil penelitian ini adalah faktor yang paling mempengaruhi Tingkat nervous pada atlet PTM ije-jela Kab.Barito Kuala adalah faktor internal sebesar 70,3 % berada di kategori tinggi.
Pengaruh Self Compassion Terhadap Kondisi Fisik Atlet Bulutangkis
Authors: Hafizt Faishal , Encep Sudirjo  , Aam Ali Rahman
Published: June 2024

Tujuan dalam penelitian ini yaitu untuk mengetahui pengaruh self compassion terhadap kondisi fisik atlet bulutangkis. Metode penelitian yang digunakan adalah metode kuantitatif dengan jenis penelitian korelasional. Populasi dalam penelitian ini yaitu atlet bulutangkis se-kecamatan jatiwangi, teknik pengambilan sampling yang digunakan dalam penelitian ini menggunakan purposive sampling dengan keriteria atlet berusia 8 – 12 tahun sebanyak 35 atlet. Teknik pengumpulan data dalam penelitian ini adalah menggunakan kuesioner self compassion dan tes kondisi fisik untuk mengetahui jawaban dari sampel dan hasil dari tes kondisi fisik. Hasil analisis data secara statistik dibantu oleh aplikasi SPSS21dengan melakukan uji Normalitas diperoleh nilai didapatkan hasil kuesioner self compassion sebesar 0,237 > 0,05 dan hasil kondisi fisik sebesar 0,136 > 0,05 sehingga data berdistribusi normal, kemudian uji linearitas diperoleh hasil 0,562 > dari 0,05 sehingga dinyatakan linear atau sejalan karena hasil dari signifikan, selanjutnya uji pearson product moment diperoleh hasil sig. (2 - tailed) 0,040 > 0,05 dan R tabel 0,334 > 0,05 maka dapat disimpulkan ada hubungan secara signifikan.  Hal  ini  menunjukkan  bahwa  setelah sampel mengisi kuisioner dan melakukan tes kondisi fisik pada cabang olahraga bulutangkis, maka hasil dari variabel self compassion terhadap kondisi fisik atlet bulutangkis memiliki pengaruh secara signifikan sebesar 0,040.
Transforming Indonesian Washing Machines into Efficient Wind Generators
Authors: Putra Ahmad Nurwanda Bawono , Firdaus Rachmat
Published: June 2024

People's consumption of household electronic devices is increasing, leading to higher energy demand in Indonesia, with washing machines being a significant contributor. This study explores repurposing used washing machine dynamos into electricity generators for windmills. Researchers used an LG washing machine dynamo and N52 neo super magnets, testing pulley diameters of 12 cm, 15 cm, 18 cm, and 20 cm. Results showed that larger pulleys increased generator output, with a 20 cm pulley producing 26 volts, 1.3 amperes, and 2525 rpm. However, the efficiency was low at 8.69%, indicating a need for further optimization. This approach has potential for sustainable energy solutions and reducing electronic waste.
 
Highlight:  
 
Repurpose Dynamos: Converts washing machines to windmill generators, reducing electronic waste.
Efficiency Challenge: Larger pulleys improve output but efficiency is only 8.69%.
Sustainable Impact: Offers potential for sustainable energy and lower household consumption.
 
 
Keyword:  household electronics, energy consumption, washing machine dynamo, windmill generator, sustainable energy
Edenic Children and Unripened Fruit
Authors: Bonar Chance
Published: June 2024

In the late thirteenth or early fourteenth century, scribes around Lake Tana in northwestern Ethiopia translated and disseminated an Arabic apocryphal dialogue between Jesus and Peter. Recording exhortations and revelations meant to be passed on to Clement of Rome and other apostolic figures, the Mystery of the Judgment of Sinners (Myst. Sinners) contains a little-explored retelling of Genesis 2–3. In its rendition of the Adam and Eve’s time in the Garden of Eden, Jesus explains to Peter how commandment not to the tree of the knowledge of good and evil was a test of their patience. In particular, Adam and Eve are marked as “children” and the fruit in terms of its “ripeness” or lack thereof. Here, I want to contextualize this claim of a dual immaturity between both the humans and plants in the Garden of Eden in terms of early Christian theological claims about the youth and imperfection of Adam and Eve.
Issue of Jesus’ multilingualism and Mark-within-Judaism
Authors: Lavender Jordan
Published: June 2024

The available evidence suggests that Jesus was portrayed as a Jewish sage, like the early Rabbis, and in his literary portrayal, he is presented as one able to speak Greek. The Aramaic phrases found in Mark and elsewhere are used in addressing God and in healing individuals who would have not spoken Greek. This implies Jesus was like other sophists, in that he was able to speak Greek. It is quite likely that his mother language was Aramaic and that he used this daily to some degree. Mark does not attempt to portray Jesus as proficient in Hebrew, something that is corrected by the later Gospel of Luke, when he portrays Jesus as reading the scrolls of the Prophets in a synagogue.
HIGHLY BIOERODED RHODOLITHS FROM THE VITÓRIA-TRINDADE SEAMOUNT CHAIN (BRAZIL, SOUTHWESTERN ATLANTIC)
Authors: FRANCO TARCILA , BASTOS ALEX CARDOSO , BASSI DAVIDE , BRAGA JUAN CARLOS
Published: June 2024

Rhodoliths are nodules mainly composed of crustose coralline algae with subordinate encrusting organisms, formed by successive overlapping encrustation. The subspheroidal rhodoliths from the Vitória-Trindade Seamount Chain (Jaseur Seamount and Trindade Island shelf; Brazil, southwestern Atlantic), sampled at water depths from 65 to 74 m, were built by crustose coralline algae (Harveylithon, Lithophyllum, Lithothamnion, Mesophyllum, Roseolithon, and Sporolithon) and subordinated encrusting foraminifera (agglutinated, unidentified hyaline, and Homotrema rubrum), bryozoans, serpulids, and balanids. Successive taphonomic phases of bioerosion, boring filling, and cement precipitation modified the original rhodolith inner structures resulting in a complex structureless mass of coralline algal fragments, encrusting organisms, borings, lithified fine-grained sediment, and carbonate cement. Borings include the ichnogenera Entobia (produced by etching sponges), Gastrochaenolites (boring bivalves) and Trypanites (polychaetes and sipunculid worms). The lithification of the material filling the borings (micrite and carbonate cements) created new substrates for subsequent bioerosion. Radiocarbon dating of selectively sampled invertebrate and algal skeletons in the rhodolith interior yielded calibrated ages of hundreds of years (up to 912 ± 152 years cal. BP on the Trindade insular shelf and up to 763 ± 131 years cal. BP on Jaseur Seamount). These values indicate growth rates from 0.1 to 0.5 mm/year, which are significantly higher than those recorded from rhodoliths at similar depths on the Brazilian shelf. Low sedimentation settings and high productivity at the tops of the seamounts and island shelf promoted the growth of nodule frame builders, both autotrophs and heterotrophs, and favored continuous activity of bioeroders.
Not a cluster of grapes, but bananas: Cord-like three-dimensional structure of cysts in ADPKD supports tubular obstruction hypothesis
Authors: Han Shuai , Yang Ming , Song Haihan , Cheng Ming , Chen Shunjie , Mei Changlin , Yang Xiu
Published: June 2024

We investigated the three-dimensional structure of the kidneys of mouse models of autosomal dominant polycystic kidney disease (ADPKD), a progressive genetic kidney disease and one of the leading causes of end-stage renal disease. We performed histological observations and transparentized the kidneys for three-dimensional imaging on rapid-onset and chronic-onset models. We found that the cysts had a cord-like structure resembling a cluster of bananas rather than a bunch of grapes, suggesting tubular obstruction as the initiating event. We also detected epithelial cell bridges within the renal tubules, which could be the cause of the obstruction. We compared the cell proliferation of kidney tissue at different developmental stages with wild type mice, and found no significant difference, indicating that there was no additional cell proliferation. Our findings support the obstruction hypothesis and challenge the proliferation hypothesis for ADPKD, and may provide new insights for finding potential treatments.
Immobilization of L-Asparaginase on Biofunctionalized Magnetic Graphene Oxide Nanocomposite: A Promising Approach for Enhanced Stability and Reusability
Authors: monajati maryam , Ariafar Nasim , Abedi Mehdi , Borandeh Sedigheh , Tamaddon Ali Mohammad
Published: June 2024

The application of the amidohydrolase enzyme, L-asparaginase (ASNase), as a biocatalyst in the food and pharmaceutical industries has garnered significant interest. However, challenges such as hypersensitivity reactions, limited stability, and reusability under various operational conditions have hindered its cost-effective utilization. This paper introduces a novel nano-support for ASNase immobilization, namely the nanocomposite of iron oxide magnetic nanoparticles and amino acid-decorated graphene oxide (GO-Asp-Fe3O4). Characterization using FTIR spectroscopy, FE-SEM, and TEM microscopy revealed the homogeneous distribution of iron oxide nanoparticles on the surface of GO sheets. The effects of carrier functionalization and carrier-to-protein ratio on the immobilization of ASNase were studied to optimize the immobilization conditions. The magnetized nanocomposite of ASNase exhibited a 4.4-fold lower Michaelis-Menten constant (Km), suggesting an enhanced affinity for the substrate. The immobilized ASNase demonstrated two to eight times higher thermostability compared to the free enzyme and showed an extremely extended pH stability range. Furthermore, the immobilized enzyme retained over 80% of its initial bioactivity after eight repeated reaction cycles. These findings suggest that the immobilization of ASNase on GO-Asp- Fe3O4 nanocomposite could be a viable option for industrial applications.
Burden of Non-prescribed drug use and its associated factors among Pregnant Women in Peri-urban kebeles’ of Jimma town, southwest Ethiopia, 2023
Authors: Yene Fentahun , Bantie Berihun , Yilma Tarekegn , Zinab Idalamin , Animen Simachew
Published: June 2024

Background: Non-prescribed drug utilization is the act of using medication to treat self-diagnosed problems without consulting a healthcare provider. Pregnant women are among the most vulnerable population groups for self-medication to treat pregnancy-related problems. The use of non-prescribed drugs, however, has numerous detrimental effects on both the growing fetus and the mother. Besides, community-based information regarding the pattern of non-prescribed drug use is limited in Ethiopia. Hence, this study aims to investigate non-prescribed drug use and its associated factors among pregnant women in Jimma town, southwest Ethiopia, in 2023.
Method and Materials: A community-based cross-sectional study was conducted among 358 pregnant mothers in the peri-urban kebeles of Jimma town, southwest Ethiopia. A systematic random sampling technique (every K = 3 households) was used to select the final study participants. Data were collected using an interviewer-administered structured questionnaire, entered into EpiData version 7.2.2 software, and exported to SPSS version 25 for further analysis. Both bivariable and multivariable logistic regression models were fitted to identify the factors influencing non-prescribed drug utilization status. The level of significance of the association was determined at a P-value < 0.05 with a 95% CI.
Result: Overall, the prevalence of non-prescribed drug use among pregnant mothers was 37.7% (95% CI: 32.8–41.7%). Enrollment in health insurance (AOR = 0.21, 95% CI: 0.03–0.76), being primigravida (AOR = 3.05, 95% CI: 1.03–5.08), and experiencing any pregnancy-related complications (AOR = 2.34, 95% CI: 1.99–2.76) were found to be significant factors affecting the non-prescribed drug utilization status of pregnant mothers.
Conclusion and recommendations: In the current study, non-prescribed drug use among pregnant mothers was high. Health insurance enrollment status, gravidity, and the presence of any pregnancy-related complications were identified as significant predictors of non-prescribed drug use among pregnant mothers. Hence, stakeholders should invest their efforts in increasing community enrollment in health insurance programs and place special emphasis on high-risk groups prone to non-prescribed drug use.
Angiogenesis and endometrial receptivity in the decidua of cesarean scar pregnancies
Authors: Liu Yu , Ma Xixiang , Du Xin , Jin Jing , Cui Yizhen , Zhou Jianshan , Song Guanglin , Li Huiman , Lei Yan
Published: June 2024

Background
Cesarean scar pregnancy (CSP) is defined as a gestational sac or trophoblast implanted within the previous cesarean scar (CS). The study aimed to investigate the mechanism of CSP.
Methods
We collected the decidua tissues of CSP patients from cesarean scar (n = 25) or uterine cavity of the same women (n = 25) at department of Gynecology, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology from July to December 2023. Morphological changes and angiogenesis in the decidua tissues were examined. And we studied the expression of the factors related to endometrial recovery. Scanning electron microscope was used to detect the number of pinopodes.
Results
The decidua tissues in the CSP-uterine scar group have more diffuse lymphocyte infiltration compared to CSP-cesarean cavity group. The vessel density (31.95 vessels/mm2) was significantly decreased in CSP-uterine scar group compared to CSP-cesarean cavity group (69.4 vessels/mm2, P<0.01). The vascular surface (0.0180 ± 0.0018 mm2/mm2) and luminal surface (1,871.00 ± 352.65 m2/vessel) was significantly smaller in CSP-uterine scar group compared to CSP-cesarean cavity group (0.0550 ± 0.0031 mm2/mm2 and 2,930.00 ± 548.14 m2/vessel, P<0.01). Compared to CSP-cesarean cavity group (7.00 ± 1.00), the number of pinopodes in CSP-uterine scar group were significantly decreased (0.33 ± 0.58). The expression of CD56, IL-6 and IL-1βin CSP-uterine scar group were significantly lower than those in CSP-cesarean cavity group.
Conclusions
There were lower angiogenesis and endometrial receptivity in cesarean scar decidua tissuess. The changes in the vascular pattern of cesarean scar decidua tissues may be beneficial for embryo implantation.
HMGB1 as a Biomarker for Myeloproliferative Neoplasm Complicated with Atherosclerosis
Authors: Wu Lunbi , Han Dongxue , Zhang Xiaodong , Zhang Shixu , Wang Yicong , Han Wenxue , Jiang Bowen , Chen Huailei , Jiang Libo
Published: June 2024

Objective
The study analyzed the correlation between levels of HMGB1 in patient's serum and biochemical indices related to atherosclerosis, clarifying the diagnostic value of HMGB1 in myeloproliferative neoplasm (MPN) complicated with atherosclerosis (AS).
Methods
Bone marrow and serum of MPN patients were collected; qPCR was used to detect the level of HMGN1 mRNA in bone marrow mononuclear cells; ELISA was used to measure the level of HMGB1 in serum. Relevant biochemical indices of the patients were also collected, and the correlation between these indices and HMGB1 was analyzed.
Results
Compared with the control group, the levels of HMGB1 in both bone marrow mononuclear cells and serum of MPN patients were significantly higher; Pearson correlation analysis showed that the level of HMGB1 in serum was negatively correlated with HDL-C and ApoA1; ROC curve showed that the AUC of serum HMGB1 in predicting AS complication in MPN was 0.929 (P < 0.001), with a sensitivity of 100.00% and a specificity of 78.05%; Logistic regression analysis showed that the level of HMGB1 in serum has statistical significance with whether the MPN patient has AS (P < 0.05).
Conclusion
The raised levels of HMGB1 in the bone marrow and serum of MPN patients show correlation with biochemical indices related to AS, which may provide reference for predicting AS complication in MPN patients.
Osimertinib plus Chemotherapy versus Osimertinib for Patients with Advanced NSCLC Concomitant EGFR and TP53 Mutations: A Prospective Cohort Study
Authors: Li Jixian , Zhan Xiang , Shao Mengqing , Zeng Renya , Li Jianan , Zhu Hui , Feng Alei , Yang Zhe , Jing Wang
Published: June 2024

Background
Osimertinib is the standard first-line options for patients with advanced EGFR-mutated non-small cell lung cancer (NSCLC). Co-mutations in TP53 results in poor survival for patients. However, the studies on treatment options and clinical outcomes of patients with EGFR-TP53 co- mutation are limited.
Methods
Patients with EGFR mutation-positive locally advanced or metastatic NSCLC carrying TP53 mutations were recruited from two institutions and allocated into two groups, either receiving osimertinib plus chemotherapy (Osi + Chemo group) or osimertinib monotherapy (Osi group). The progression-free survival (PFS) was evaluated as the primary endpoint and the response was also assessed.
Results
Between January 2020 and August 2023, Ninety-eight patients were enrolled with 47 and 51 patients receiving combination therapy and the monotherapy. After a median follow-up of 19.2 months, overall response rate (ORR) was 80.0% versus 71.7% (p = 0.36), favoring Osi + Chemo group, as well as in disease control rate (DCR) (91.4% vs. 80.4%, p = 0.45). The median PFS in the Osi + Chemo group was 26.0 months versus 20.7 months in the Osi group, but without significant difference (p = 0.34). The subgroup analysis indicated that for patients with L858R mutation, Osi + Chemo therapy significantly prolonged the median PFS (not reached [NR] versus 17.1 months, p = 0.03), but not in patients with 19Del (20.6 months versus NR, p = 0.31).
Conclusion
Osimertinib plus chemotherapy have a tendency to increase ORR and prolong PFS in NSCLC with EGFR and TP53 co-mutations, particularly in patients with L858R mutation.
Exchange Rate Regime Choices and Real Effective Exchange Rate Misalignments: Degree and Persistence
Authors: Byusa Vincent , Byusa Vincent
Published: June 2024

This paper assesses the impact of de facto exchange rate regime (ERR) choices on the magnitude and the persistence of multilateral price levels-based (also known as real effective exchange rate, REER) misalignments in a large sample of countries (126) over the period 1990–2019. This paper considers the random effects within-between (REWB) framework to evaluate the degree of REER misalignments and the novel mean-group instrumental variables (MGIV) to estimate the persistence of the REER misalignments. This paper finds that both fixed and intermediate ERRs perform better in limiting the degree of REER misalignment than the floating ERRs Furthermore, this paper finds evidence of the strongest persistence of REER misalignment in the fixed and intermediate ERRs. These results indicate that the choice of ERR is relevant to REER misalignment.
JEL codes: C33, F32, F31, F33, F41
Choriocarcinoma metastases complicated with cerebral venous sinus thrombosis in the third trimester of pregnancy: a case report and literature review
Authors: Wang Sheng , Wang Changrong , You Feng
Published: June 2024

Background Intracerebral hemorrhage (ICH) in younger females is usually attributed to ruptured aneurysms or cerebrovascular malformations. By contrast, metastatic brain tumors and complications stemming from intracranial venous sinus thrombosis (CVST)-associated hemorrhagic strokes are rare instigators of ICH in women of childbearing age. We report a case of choriocarcinoma metastasis with rapid progression of cerebral venous sinus thrombosis in a patient in the third trimester. Additionally, the literature review revealed only two cases where choriocarcinoma was complicated by CVST, and both were identified post-chemotherapy.
Case presentation A case of a 33-year-old expectant woman, in her 32+ weeks of pregnancy, sought hospital admission owing to persistent blurred vision that had prevailed for over half a month. After her admission, she endured three instances of ICH within only one week, during which period digital subtraction angiography unveiled the presence of thrombosis within the superior sagittal sinus. Choriocarcinoma in the third trimester with lung and brain metastases, ICH, and CVST. The patient underwent an emergency caesarean section and delivered a premature baby girl. Catheter directed thrombolysis in the intracranial venous sinus and evacuation of the hematoma by craniotomy were subsequently performed. Eventually, this patient was diagnosed with choriocarcinoma with multiple metastases and received drug chemotherapy.
Conclusions The symptoms and imaging findings of brain metastases with hemorrhage and CVST overlap with each other, resulting in delaying and confusing the diagnosis. Furthermore, early diagnostic interventions for choriocarcinoma coupled with intensive treatment strategies can potentially improve patient prognosis and help avoid life-threatening consequences.
Exploring the Relationship Between Land Use and Pesticide Contamination in a Tropical Rural Catchment: A Case Study of River Chanchaga
Authors: Ikayaja Eunice O. , Tshimanga Raphael M. , Ndatimana Gilbert , Zabbey Nenibarini , Arimoro Francis O.
Published: June 2024

Freshwater ecosystems are vulnerable to various land uses, resulting in concern for aquatic organisms and humans. Understanding the occurrence of pesticide contamination is necessary to safeguard aquatic biodiversity and human health. Against this background, our study aimed to assess the effect of various land uses on pesticide contamination by evaluating three selected sites according to land use class: a control site (CON), an agricultural area (S1), and an urban area (S2). Various classes of land use around the catchment were determined using ArcGIS 10.8 GIS software, while analysis of pesticide residues was carried out using the liquid-liquid extraction method, followed by gas chromatography-mass spectrometry (GC/MS). A total of 10 herbicides and 12 insecticides were recorded in each sampled sub-catchment, with a statistically significant difference across the sampled sub-catchment. Sampled sites located in agricultural and urban areas recorded higher concentrations of pesticide residues compared to sites located in natural areas, with less anthropogenic influence, reflecting differences in pesticide usage. Redundancy analysis (RDA) revealed crops and urbanized land use were the main sources of pesticide contamination in the water, as pesticides are predominantly used on farms and in various households. Their presence in the water may have potentially detrimental effects on aquatic biodiversity because pesticides have been associated with various health issues. It was evident that all sampled sub-catchments had pesticide concentrations exceeding the WHO permissible limit for human consumption. Implementing alternative methods for managing pests and weeds without relying on pesticides is crucial for sustainable agriculture and environmental preservation.
A Blockchain Auto-Scaling Node Organizing Design Model for the Internet of Things
Authors: ELSAADANY Riham , Bégin Guy
Published: June 2024

Many node-organizing blockchain models for IoT lack the scalability needed for high transaction volumes and mechanisms to manage decentralization and node overhead. This study proposes a multi-tiered Self-Scalable Dynamic architecture based on a forest of trees to improve scalability and efficiency by clustering all nodes to limit those involved in consensus. In addition to the architecture, our contributions include: i) A protocol to speed up consensus. ii) A mechanism for efficient node-lookup and message-routing. iii) A dynamic algorithm to balance overhead and decentralization. iv) A colocality mechanism to enhance consensus time. This architecture reduces consensus time with an upper bound of O(1) plus a propagation delay factor. As more IoT devices join, resulting in a deeper forest, the model becomes more scalable with shorter consensus delays. The proposed mechanisms may serve as general-purpose solutions for scalability, load balancing, node-lookup and message-routing, and are application-, clustering-, and consensus-algorithm-agnostic.