bluuebunny/crossref_metadata_2025 huggingface dataset:
Bark extract of Cassia sieberiana DC. (Caesalpiniaceae) displayed good antibacterial activity against MDR gram-negative phenotypes in the presence of phenylalanine-arginine β-naphthylamide
Authors: Ambadiang Marilene M. M. , Atontsa Brice C. K. , Tankeo Simplice B. , Nayim Paul , Wamba Brice E. N. , Bitchagno Gabin T. M. , Mpetga James D. S. , Penlap Veronique B. , Kuete Victor
Published: November 2020

Background

Multidrug-resistant (MDR) bacteria remain a major cause of morbidity and mortality globally. The present study was designed to investigate the in vitro antibacterial activities of crude methanol extract and constituents isolated by Column Chromatography (CC) fromCassia sieberianabark (CSB) against ten MDR Gram-negative bacteria, as well as the mechanisms of action of the most active sample.

Methods

The antibacterial activity of the tested samples (extract, the fractions and their compounds isolated by CC and the structures obtained by exploiting1H and13CNuclear magnetic resonance(NMR) spectra) in the presence and absence of an efflux pumps inhibitor, phenylalanine-arginine β-naphthylamide (PAβN), was evaluated using the micro-dilution method. The effects of the most active sample were evaluated on the cell growth kinetic and on the bacterial H+-ATPase proton pumps.

Results

Phytochemical composition of the crude extract showed a rather selective distribution of secondary metabolites (presence of polyphenols, tannins, steroids, triterpenes, flavonoids, alkaloids, saponins and absence of anthocyanins, anthraquinones). The tested samples displayed different antibacterial activities with minimal inhibitory concentrations (MICs) ranging from 64 to 512 μg/mL. Crude extract (CS) and fraction CSc showed the highest inhibitory spectra, both inhibiting all of the studied bacteria exceptEnterobacter aerogenesEA27 strain. Fraction CSc exerted bactericidal effects on most bacteria meanwhile, crude extract (CS) and sub-fraction CSc2 exerted bacteriostatic effects. Compounds 1 (spectaline) and 2 (iso-6-cassine) inhibited the growth of 70% (Escherichia coliATCC8739 and AG102,Klebsiella pneumoniaeATCC11296,Enterobacter aerogenesATCC13048 and EA27,Providencia stuartiiATCC29916,Pseudomonas aeruginosaPA01) and 60% (Escherichia coliATCC8739,Klebsiella pneumoniaeATCC11296 and KP55,Providencia stuartiiATCC29916,Pseudomonas aeruginosaPA01 and PA124) of bacteria respectively with MICs ranging from 128 to 512 μg/mL. In the presence of PAβN, the activities of crude extract CS, fraction CAc and sub-fraction CSc2 strongly increased on most bacteria strains as their MICs significantly decreased. Sub-fraction CSc2 inhibited the H+-ATPase proton pumps and altered growth kinetic ofEscherichia coliATCC8739.

Conclusion

The overall results justify the traditional use ofC. sieberianafor the treatment of bacterial infections.
Developing and maintaining the resilience of interdisciplinary cancer care teams: an interventional study
Authors: Dubois Carl-Ardy , Borgès Da Silva Roxane , Lavoie-Tremblay Mélanie , Lespérance Bernard , Bentein Kathleen , Marchand Alain , Soldera Sara , Maheu Christine , Grenier Sébastien , Fortin Marie-Andrée
Published: November 2020

Background

Providing care to cancer patients is associated with a substantial psychological and emotional load on oncology workers. The purpose of this project is to co-construct, implement and assess multidimensional intervention continuums that contribute to developing the resilience of interdisciplinary cancer care teams and thereby reduce the burden associated with mental health problems. The project is based on resources theories and theories of empowerment.

Methods

The study will involve cancer care teams at four institutions and will use a mixed-model design. It will be organized into three components:

(1) Intervention development.Rather than impose a single way of doing things, the project will take a participatory approach involving a variety of mechanisms (workshops, discussion forums, surveys, observations) to develop interventions that take into account the specific contexts of each of the four participating institutions.

(2) Intervention implementation and assessment.The purpose of this component is to implement the four interventions developed in the preceding component, assess their effects and whether they are cost effective. A longitudinal quasi-experimental design will be used. Intervention monitoring will extend over 12 months. The effects will be assessed by means of generalized estimating equation regressions. A cost-benefit analysis will be performed to assess the cost-effectiveness of the interventions, taking an institutional perspective (costs and benefits associated with the intervention).

(3) Analysis of co-construction and implementation process.The purpose of this component is to (1) describe and assess the approaches used to engage stakeholders in the co-construction and implementation process; (2) identify the factors that have fostered or impeded the co-construction, implementation and long-term sustainability of the interventions. The proposed design is a longitudinal multiple case study.

Discussion

In the four participating institutions, the project will provide an opportunity to develop new abilities that will strengthen team resilience and create more suitable work environments. Beyond these institutions, the project will generate a variety of resources (e.g.: work situation analysis tools; method of operationalizing the intervention co-development process; communications tools; assessment tools) that other oncology teams will be able to adapt and deploy elsewhere.
Sex differences in neuro(auto)immunity and chronic sciatic nerve pain
Authors: Linher-Melville Katja , Shah Anita , Singh Gurmit
Published: November 2020

Chronic pain occurs with greater frequency in women, with a parallel sexually dimorphic trend reported in sufferers of many autoimmune diseases. There is a need to continue examining neuro-immune-endocrine crosstalk in the context of sexual dimorphisms in chronic pain. Several phenomena in particular need to be further explored. In patients, autoantibodies to neural antigens have been associated with sensory pathway hyper-excitability, and the role of self-antigens released by damaged nerves remains to be defined. In addition, specific immune cells release pro-nociceptive cytokines that directly influence neural firing, while T lymphocytes activated by specific antigens secrete factors that either support nerve repair or exacerbate the damage. Modulating specific immune cell populations could therefore be a means to promote nerve recovery, with sex-specific outcomes. Understanding biological sex differences that maintain, or fail to maintain, neuroimmune homeostasis may inform the selection of sex-specific treatment regimens, improving chronic pain management by rebalancing neuroimmune feedback. Given the significance of interactions between nerves and immune cells in the generation and maintenance of neuropathic pain, this review focuses on sex differences and possible links with persistent autoimmune activity using sciatica as an example.
A comprehensive research agenda for zero leprosy
Authors: Steinmann Peter , Dusenbury Courtenay , Addiss David , Mirza Fareed , Smith W. Cairns S.
Published: November 2020

Background

Leprosy control achieved dramatic success in the 1980s–1990s with the implementation of short course multidrug therapy, which reduced the global prevalence of leprosy to less than 1 in 10 000 population. However, a period of relative stagnation in leprosy control followed this achievement, and only limited further declines in the global number of new cases reported have been achieved over the past decade.

Main text

In 2016, major stakeholders called for the development of an innovative and comprehensive leprosy strategy aimed at reducing the incidence of leprosy, lowering the burden of disability and discrimination, and interrupting transmission. This led to the establishment of the Global Partnership for Zero Leprosy (GPZL) in 2018, with partners aligned around a shared Action Framework committed to achieving the WHO targets by 2030 through national leprosy program capacity-building, resource mobilisation and an enabling research agenda. GPZL convened over 140 experts from more than 20 countries to develop a research agenda to achieve zero leprosy. The result is a detailed research agenda focusing on diagnostics, mapping, digital technology and innovation, disability, epidemiological modelling and investment case, implementation research, stigma, post exposure prophylaxis and transmission, and vaccines. This research agenda is aligned with the research priorities identified by other stakeholders.

Conclusions

Developing and achieving consensus on the research agenda for zero leprosy is a significant step forward for the leprosy community. In a next step, research programmes must be developed, with individual components of the research agenda requiring distinct expertise, varying in resource needs, and operating over different timescales. Moving toward zero leprosy now requires partner alignment and new investments at all stages of the research process, from discovery to implementation.
Broad Spectrum epidemiological contribution of cannabis and other substances to the teratological profile of northern New South Wales: geospatial and causal inference analysis
Authors: Reece Albert Stuart , Hulse Gary Kenneth
Published: November 2020

Background

Whilst cannabis commercialization is occurring rapidly guided by highly individualistic public narratives, evidence that all congenital anomalies (CA) increase alongside cannabis use in Canada, a link with 21 CA’s in Hawaii, and rising CA’s in Colorado indicate that transgenerational effects can be significant and impact public health. It was therefore important to study Northern New South Wales (NNSW) where cannabis use is high.

Methods

Design: Cohort. 2008–2015. Setting: NNSW and Queensland (QLD), Australia. Participants. Whole populations. Exposures. Tobacco, alcohol, cannabis. Source: National Drug Strategy Household Surveys 2010, 2013. Main Outcomes. CA Rates. NNSW-QLD comparisons. Geospatial and causal regression.

Results

Cardiovascular, respiratory and gastrointestinal anomalies rose with falling tobacco and alcohol but rising cannabis use rates across Queensland. Maternal age NNSW-QLD was not different (2008–2015: 4265/22084 v. 96,473/490514 > 35 years/total, Chi.Sq. = 1.687, P = 0.194). A higher rate of NNSW cannabis-related than cannabis-unrelated defects occurred (prevalence ratio (PR) = 2.13, 95%C.I. 1.80–2.52, P = 3.24 × 10− 19). CA’s rose more potently with rising cannabis than with rising tobacco or alcohol use. Exomphalos and gastroschisis had the highest NNSW:QLD PR (6.29(2.94–13.48) and 5.85(3.54–9.67)) and attributable fraction in the exposed (84.11%(65.95–92.58%) and 82.91%(71.75–89.66%), P = 2.83 × 10− 8 and P = 5.62 × 10− 15). In multivariable geospatial models cannabis was significantly linked with cardiovascular (atrial septal defect, ventricular septal defect, tetralogy of Fallot, patent ductus arteriosus), genetic (chromosomal defects, Downs syndrome), gastrointestinal (small intestinal atresia), body wall (gastroschisis, diaphragmatic hernia) and other (hypospadias) (AVTPCDSGDH) CA’s. In linear modelling cannabis use was significantly linked with anal stenosis, congenital hydrocephalus and Turner syndrome (ACT) and was significantly linked in borderline significant models (model P < 0.1) with microtia, microphthalmia, and transposition of the great vessels. At robust and mixed effects inverse probability weighted multivariable regression cannabis was related to 18 defects. 16/17 E-Values in spatial models were > 1.25 ranging up to 5.2 × 1013 making uncontrolled confounding unlikely.

Conclusions

These results suggest that population level CA’s react more strongly to small rises in cannabis use than tobacco or alcohol; cardiovascular, chromosomal, body wall and gastrointestinal CA’s rise significantly with small increases in cannabis use; that cannabis is a bivariate correlate of AVTPCDSGDH and ACT anomalies, is robust to adjustment for other substances; and is causal.
Evaluating motivational characteristics in vocational music education within the perspective of self-determination theory
Authors: Virkkula Esa
Published: November 2020

This article examines the influence of vocational music education workshops on the learning motivation of popular and jazz music students in a self-determination theory’s (SDT) framework. SDT illustrates that satisfying people’s universal psychological needs has a significant influence on well-being and learning. Psychological needs will become satisfied when the learner autonomously influences the choices and decisions of his or her learning. The learner feels then competent to act in the learning environment and receive the experiences related to it. The present article is based on a qualitative research project that examined 62 Finnish conservatory popular and jazz music students who participated in 11 music performance workshops with professional musicians in 2003–2011. The research data consists of (a) workshop plans and learning goals written by the students before the workshops and (b) reflective essays of experiences after the workshops. The data was analysed using theory-oriented content analyses. The students were responsible for the planning and implementation of music performances with professional musicians. Commitment to challenging performance projects with professional musicians motivated the students to try their best to develop their musicianship.
Utilizing technologies of fog computing in educational IoT systems: privacy, security, and agility perspective
Authors: Adel Amr
Published: November 2020

Fog computing architecture is referred to the architecture that is distributed over the geographical area. This architectural arrangement mainly focuses on physical and logical network elements, and software for the purpose of implementing proper network. Fog computing architecture allows the users to have a flexible communication and also ensures that the storage services are maintained efficiently for the purpose of managing the data. However, it has been observed that in the field of education fog computing architecture has gained huge importance due to its real time application feature. The main objective of the survey is to develop a systematic literature review for the technology of fog computing in the education IoT system. The survey will also focus on evaluating the essential factors that has a crucial role in the fields of education as well as investigating the limitation and findings associated with the fog computing technologies in educational systems from the perspective of privacy, security, and agility.
Recent advances in the intellectual property landscape of filamentous fungi
Authors: Hüttner Silvia , Johansson Anton , Gonçalves Teixeira Paulo , Achterberg Puck , Nair Ramkumar B.
Published: November 2020

For centuries, filamentous fungi have been used in the making of food and beverages, and for decades for the production of enzymes and pharmaceuticals. In the last decades, the intellectual property (IP) landscape for fungal technology has seen an ever increasing upward trend, introducing new and promising applications utilising fungi. In this review, we highlight fungi-related patent applications published during the last 5 years (2015–2020), identify the key players in each field, and analyse future trends. New developments in the field of fungal technology include the increased use of filamentous fungi as a food source (mycoprotein), using fungi as biodegradable materials, in wastewater treatment, in integrated biorefineries and as biological pest agents. Biotechnology companies in Europe and the US are currently leading when it comes to the number of patents in these areas, but Asian companies and research institutes, in particular in China, are becoming increasingly important players, for example in pesticide formulation and agricultural practices.
Annual and spatial variabilities in the acorn production of Quercus mongolica
Authors: Noh Jaesang , Kim Youngjin , Lee Jongsung , Cho Soyeon , Choung Yeonsook
Published: November 2020

Background

Genus Quercus is a successful group that has occupied the largest area of forest around the world including South Korea. The acorns are an important food source for both wild animals and humans. Although the reproductive characteristics of this genus are highly variable, it had been rarely studied in South Korea. Therefore, in Seoraksan and Odaesan National Parks (i) we measured the acorn production of Quercus mongolica, an overwhelmingly dominant species in South Korea, for 3 years (2017–2019), (ii) evaluated the spatial-temporal variation of acorn production, and (iii) analyzed the effects of oak- and site-related variables on the acorn production.

Results

The annual acorn production of Q. mongolica increased 36 times from 1.2 g m−2 in 2017 to 43.2 g m−2 in 2018, and decreased to 16.7 g m−2 in 2019, resulting in an annual coefficient of variation of 104%. The coefficient of spatial variation was high and reached a maximum of 142%, and the tree size was the greatest influencing factor. That is, with an increase in tree size, acorn production increased significantly (2018 F = 16.3, p < 0.001; 2019 F = 8.2, p < 0.01). Elevation and slope also significantly affected the production in 2019. However, since elevation and tree size showed a positive correlation (r = 0.517, p < 0.001), the increase in acorn production with increasing elevation was possibly due to the effect of tree size. The acorn production of Odaesan for 3 years was 2.2 times greater than that of Seoraksan. This was presumed that there are more distribution of thick oak trees and more favorable site conditions such as deep soil A-layer depth, high organic matter, and slower slopes.

Conclusion

As reported for other species of the genus Quercus, the acorn production of Q. mongolica showed large spatial and annual variations. The temporal variability was presumed to be a weather-influenced masting, while the spatial variability was mainly caused by oak tree size.
Dexamethasone as a bupivacaine adjuvant for ultrasound-guided interscalene brachial plexus block: a prospective randomized study
Authors: Badran Maha Abd el Fattah Metawie , Kamaly Ayman Mokhtar , Abdel Hamid Hadil Magdy , Mostafa Raham Hassan
Published: November 2020

Background

Finding adjuvants to local anesthetic used in interscalene block that could efficiently extend the analgesia duration has recently been the focus of researchers. The aim of the work was to determine whether the addition of perineural dexamethasone to bupivacaine in-ultrasound guided interscalene block would prolong the duration of sensory analgesia in patients undergoing shoulder surgery.

Results

This prospective, randomized, double-blinded study comprised 50 patients. They were randomly subdivided into 2 groups: group C [control] and group D [dexamethasone]. We noted a significant difference regarding the timing for the first rescue analgesia being shorter in group C than in group D with a P value < 0.001. Regarding postoperative analgesia, higher Ketolac consumption was noticed in group C than in group D. Patients from both groups showed excellent analgesic effects with VAS score less than 2 points up to 6 h postoperative then patients in group C had a higher VAS score compared to group D, and the difference was statistically significant (P value < 0.05). We also noticed an increase in the heart rate and mean arterial blood pressure in group C than in group D at 12 h and 24 h postoperatively.

Conclusion

We concluded that the addition of 8 mg of perineural dexamethasone to 30 ml of 0.5% bupivacaine showed improvement in the postoperative analgesia in shoulder surgery without obvious complications.
Skeletal Muscle and Metabolic Health: How Do We Increase Muscle Mass and Function in People with Type 2 Diabetes?
Authors: Al-Ozairi Ebaa , Alsaeed Dalal , Alroudhan Dherar , Voase Nia , Hasan Amal , Gill Jason M R , Sattar Naveed , Welsh Paul , Gray Cindy M , Boonpor Jirapitcha , Celis-Morales Carlos , Gray Stuart R
Published: November 2020

Background

Whilst skeletal muscles’ primary role is allowing movement, it has important metabolic roles, including in glycemic control. Indeed, evidence indicates that low muscle mass and function are associated with an increased risk of type 2 diabetes, highlighting its importance in the development of metabolic disease.

Methods

In this mini-review, we detail the evidence highlighting the importance of muscle in type 2 diabetes and the efficacy of resistance exercise in improving glycemic control alongside our approach to increase uptake of such exercise in people with type 2 diabetes. This summary is based in the authors’ knowledge of the filed supplemented by a Pubmed search using the terms “muscle,” “glycemic control,” “HbA1c,” “type 2 diabetes,” and “resistance exercise.”

Results

The main strategy to increases muscle mass is to perform resistance exercise and, although the quality of evidence is low, such exercise appears effective in reducing Glycated Haemoglobin (HbA1c) in people with type 2 diabetes. However, to increase participation we need to improve our understanding of barriers and facilitators to such exercise. Current data indicate that barriers are similar to those reported for aerobic exercise, with additional resistance exercise specific barriers of looking to muscular, increase risk of cardiovascular event, having access to specialized equipment and knowledge of how to use it.

Conclusions

The development of simple resistance exercises that can be performed anywhere, that use little or no equipment and are effective in reducing HbA1c will be, in our opinion, key to increasing the number of people with type 2 diabetes performing resistance exercise.
Checking the Checkpoint Inhibitors: A Case of Autoimmune Diabetes After PD-1 Inhibition in a Patient with HIV
Authors: Hughes Michael S , Pietropaolo Massimo , Vasudevan Madhuri M , Marcelli Marco , Nguyen Ha
Published: November 2020

Immune checkpoint inhibitor–associated diabetes mellitus (ICI-DM) is a known immune-related adverse event (irAE) following treatment with programmed cell death protein 1 (PD-1), with a reported 0.9% incidence. We hereby present the first case, to our knowledge, of ICI-DM following ICI use in a human immunodeficiency virus (HIV) patient. In this case, a 48-year-old man with HIV stable on highly active antiretroviral therapy (HAART) was diagnosed with Hodgkin lymphoma and initiated treatment with the PD-1 inhibitor nivolumab. His lymphoma achieved complete response after 5 months. However, at month 8, he reported sudden polydipsia and polyuria. Labs revealed a glucose level of 764 mg/dL and glycated hemoglobin A1c (HbA1c) of 7.1%. Low C-peptide and elevated glutamic acid decarboxylase 65 (GAD65) antibody levels confirmed autoimmune DM, and he was started on insulin. Major histocompatibility complex class II genetic analysis revealed homozygous HLA DRB1*03-DQA1*0501-DQB1*02 (DR3-DQ2), which is a known primary driver of genetic susceptibility to type 1 DM. Autoimmune DM has been reported as an ICI-associated irAE. However, patients with immunocompromising conditions such as HIV are usually excluded from ICI trials. Therefore, little is known about such irAEs in this population. In this case, risk of ICI-DM as an irAE was likely increased by several factors including family history, a high-risk genetic profile, islet-related immunologic abnormalities, active lymphoma, and HIV infection with a possible immune reconstitution event. Clinicians should maintain a high index of suspicion for development of irAEs associated with ICI, particularly as use of these therapies broadens. Thorough investigation for presence of higher-risk features should be conducted and may warrant inclusion of pre-therapy genetic and/or autoantibody screening.
The Trail, the Archive, the Museum, and the Book: Confronting Materiality in Literary Studies
Authors: Haubenreich Jacob
Published: November 2020

This article examines the persistence of the notion of the immaterial text in literary studies, now decades into the so-called material turn. Digitization of manuscripts increasingly confronts us with the facts of textual materiality and material authorship, yet many scholars remain ill-equipped to engage these traces in order to expand the possibilities of textual interpretation. The journeys of Peter Handke’s notebooks serve as a case study on how to interrogate various definitions of text and methodological approaches that reinforce an understanding of texts as immaterial. This article thus elucidates the conceptual and methodological impediments to more comprehensively integrating materiality into interpretation; an uneasiness, for example, about approaching authorship—the process and agency of textual production—lingers despite resurrections since the Author’s “death” and more recent transdisciplinary retheorizations of agency. The article finally looks to reflections on materiality in another field, art history, to clarify the reasons that integrating materiality into interpretative criticism remains so difficult, so that the field might begin to move beyond these obstacles.
The Making of Viequenses
Authors: Cruz Soto Marie
Published: November 2020

This article delves into the history of medical institutions, birthing practices, and reproductive rights in Vieques. The exploration exposes contradictions at the heart of Puerto Rico’s colonial modernity. Around the middle of the twentieth century, Puerto Ricans were encouraged to depend on the colonial state and medical establishment for guarantee of life, health, and general well-being. This encouragement clashed with the militarized colonialism imposed on Viequenses. The 1940s expropriations—through which the U.S. Navy gained control over three-fourths of Vieques—devastated the community. And the interventions by the colonial state and medical establishment proved at times meek, complicit, and ineffective. In 2003, unruly colonial citizens evicted the Navy. Their actions were part of a struggle for the survival and well-being of the Viequense island community. In this article, the author argues that la lucha viequense has been fundamentally shaped by the concerns and actions of women who placed reproductive rights at the center of the struggle.
Uncharted routes: exploring the relevance of auxin movement via plasmodesmata
Authors: Paterlini Andrea
Published: November 2020

Auxin is an endogenous small molecule with an incredibly large impact on growth and development in plants. Movement of auxin between cells, due to its negative charge at most physiological pHs, strongly relies on families of active transporters. These proteins import auxin from the extracellular space or export it into the same. Mutations in these components have profound impacts on biological processes. Another transport route available to auxin, once the substance is inside the cell, are plasmodesmata connections. These small channels connect the cytoplasms of neighbouring plant cells and enable flow between them. Interestingly, the biological significance of this latter mode of transport is only recently starting to emerge with examples from roots, hypocotyls and leaves. The existence of two transport systems provides opportunities for reciprocal cross-regulation. Indeed, auxin levels influence proteins controlling plasmodesmata permeability, while cell–cell communication affects auxin biosynthesis and transport. In an evolutionary context, transporter driven cell–cell auxin movement and plasmodesmata seem to have evolved around the same time in the green lineage. This highlights a co-existence from early on and a likely functional specificity of the systems. Exploring more situations where auxin movement via plasmodesmata has relevance for plant growth and development, and clarifying the regulation of such transport, will be key aspects in coming years.

This article has an associated Future Leader to Watch interview with the author of the paper.
Concomitant weekly cisplatin-based chemoradiotherapy in head and neck cancer: the value of a second measured glomerular filtration rate during treatment
Authors: Akmar Lily , Cunnell Michelle , Kelly Charles , Kovarik Josef , Iqbal Muhammad Shahid
Published: November 2020

Objectives:

To assess the efficacy of the second measured glomerular filtration rate (GFR) during the course of weekly cisplatin-based chemoradiotherapy in head and neck cancer.

Methods:

Data was collected on consecutive 221 head and neck cancer patients who underwent cisplatin-based chemoradiotherapy.

Results:

68% patients managed to complete at least five out six proposed cycles of cisplatin, with a cumulative dose of ≥200 mg/m2. 181 patients underwent second measured GFR and it showed a mean fall in measured GFR by 12.0 ml/min/1.73 m2 (p < 0.0001). Out of these 181 patients, in 16 patients (9%), the decision to discontinue cisplatin was purely based on a low second measured GFR (below 50 ml/min/1.73 m2).

Conclusion:

Our study has shown that obtaining a second measured GFR is valuable in 9% of these patients. We propose that this should be considered as a standard procedure in these settings and also should be considered incorporating this additional safety measure, into future clinical trials as a mandatory procedure.

Advances in knowledge:

To the best of author’s knowledge, this is first study of its kind. The results of our study suggest that it should be a standard procedure of obtaining a second GFR in these settings.
Insetos Calçados: calçando uma causa
Authors: Batista Renata de Lima Marques , Barboza Stephanie Ingrid Souza
Published: November 2020

O caso tem como objetivo permitir um estudo mais aprofundado sobre segmentação de mercado, posicionamento de marcas e construção do brand equity. O caso descreve o contexto da empresa Insetos Calçados, marca de calçados e acessórios veganos e ecológicos. Em seu posicionamento, a empresa adota uma postura de preocupação com o planeta. Todas as suas peças são produzidas de modo artesanal, a partir de materiais reaproveitados, como roupas de brechós, tecido de garrafa PET, laminado vegetal, entre outros. Esse interesse pela moda ética e o desejo por produzir calçados sem causar impactos ambientais resultaram em peças veganas, sem nada de origem animal. Atualmente, o nicho de moda vegana está em constante expansão, dessa forma esse mercado vem se tornando cada vez mais competitivo. Diante disso, é essencial que a Insetos encontre meios para aproveitar esse crescimento do mercado vegano sem perder a sua característica de exclusividade dos produtos e de ser artesanal.
O desafio da discussão de estratégia em pequenas empresas: o caso SportAção
Authors: Tonon Bruno , Sakajiri Lucas Jun , Sarfati Gilberto
Published: November 2020

A SportAção é uma empresa de pequeno porte, pioneira na produção de camisas e uniformes esportivos personalizados, atuando também na revenda de artigos esportivos, com operações totalmente concentradas no varejo físico. Em 2020, a empresa completa 35 anos diante de inúmeros desafios internos e externos, marcando, ainda, o encerramento de um plano de cinco anos estabelecido com o principal objetivo de reverter uma sequência de quedas no faturamento. A nova discussão sobre estratégia e construção do plano 2025 envolverá, entre outros assuntos, a profissionalização da gestão, crescimento das operações, transformação digital e políticas de recursos humanos.
E agora, José? Terceirizar resolve?
Authors: Lucatelli Francine , Petry Marcelo , Tormen-Ferreira João Anselmo , Simão Luiz Eduardo
Published: November 2020

Uma multinacional passa por dificuldades nas operações de importação e exportação. A situação é percebida por José, um novo gestor contratado para gerenciar a equipe de comércio exterior. José diagnostica os problemas existentes, prognosticando dois cenários possíveis para solucioná-los: a terceirização ou o aumento da equipe de comércio exterior. Sugere-se a aplicação desse caso para alunos de cursos de graduação em Administração, Comércio Exterior e Logística.
Meu negócio não pode morrer: dilemas da expansão de um cemitério-parque
Authors: Matos Carolina Maria Furtado , Queiroz Ayrton Santos , Da Silva Denilson Pereira , Garcia Roberta Ribeiro , Dos Santos Ruan Carlos
Published: November 2020

Este caso de ensino tem como objetivo analisar as estratégias utilizadas em um dos cemitérios mais conhecidos do Brasil. Os empreendedores estão passando por um dilema em que se encontram com duas alternativas, crescer ou crescer. Conduzido pela sua paixão de inovar, Diego decidiu mudar o modo como as pessoas em sua cidade enxergavam o negócio de sua família, um cemitério. Foi quando contratou uma empresa para ajudá-lo nessa empreitada, com a utilização do marketing digital. Tudo deu muito certo, mas com alguns erros ao longo do caminho. Aumentou o número de vendas de seus serviços e produtos, e, então, decidiram começar a pensar em expandir o negócio. O caso possibilita ao professor explorar temas voltados para o perfil empreendedor, as cinco forças de Porter e posicionamento estratégico. Ao final da leitura, os alunos serão convidados a propor soluções para o negócio da família de Diego.
Διερεύνηση της ανάπτυξης του προφορικού λόγου και της δημιουργικής σκέψης των παιδιών προσχολικής ηλικίας, μέσα από διδακτικές παρεμβάσεις αξιοποίησης της εικαστικής τέχνης
Authors: Μακρή-Μπότσαρη Ευανθία , Τογαντζή Πολυξένη , Σοφού Ευστρατία
Published: November 2020

The aim of this study was to investigate the contribution of visual art to thedevelopment of oral language and creative thinking of toddlers in the context of a targeted teaching intervention in a kindergarten classroom in Athens. The pupils came in contact with artworks based on Perkins’ methodical art observation model. The intervention lasted for three months and involved 20 children (15 toddlers aged 5-years-old and 5 toddlers aged 4-years-old). Language skills and creative thinking were evaluated at the beginning and at the end of the intervention. Data was collected through group discussion, interviews and children’s personal artworks. The results showed that after the intervention, substantial changes were observed in both the language skills and creative thinking of the children. In particular, children’s narratives were better in structure and quality, vocabulary was richer, and more children participated in a discussion in comparison with the beginning of the intervention. In terms of creative thinking, a higher level of hypothesis was made, more ideas were produced, and mainly more visual works based on the observed works of art were produced by the children. This paper contributes to research into the development of oral language skills and creative thinking, highlighting the relationship between visual arts and the development of toddlers’ basic preschool skills.
Ο Μεσολαβητικός Ρόλος της Εχθρικής Απόδοσης Αιτιότητας στη Σχέση της Προσωπικότητας με τον Κυβερνο-Εκφοβισμό
Authors: Κόκκινος Κωνσταντίνος , Αντωνιάδου Ναυσικά , Βουλγαρίδου Ιωάννα
Published: November 2020

The aim of this study was to investigate the association of the Big Five personality traits, Hostile Attribution Bias, and cyber-bullying among 347 Greek students attending the last grade of primary school and Junior High School. In order to explore whether the effect of personality traits on cyber-bullying is better explained through Hostile Attribution Bias, a mediation analysis was run. Results showed that Hostile Attribution Bias mediated the links between high Neuroticism, and low Extraversion on the one hand and cyber-bullying on the other. Overall, findings suggest that individuals low in Emotional Stability and less sociable are more likely to manifest cyber-bullying due to their tendency to attribute hostile intent, which may be exacerbated during computer mediated communication, which frequently provides limited social cues to the user. Findings can contribute towards the prevention and intervention of cyber-bullying through programs which help students interpret ambiguous social interactions.
Ψυχοπαιδαγωγικά προγράμματα πρόληψης και παρέμβασης στο σχολικό πλαίσιο: θεωρητικές προσεγγίσεις και ερευνητικά δεδομένα
Authors: Φιλιππάτου Διαμάντω , Δημητροπούλου Παναγιώτα
Published: November 2020

Discussion.Abstract non available.
Γνωστική και μεταγνωστική επίδοση των παιδιών κατά την προσχολική και πρώτη σχολική ηλικία: Ρυθμός ανάπτυξης και ατομικές διαφορές
Authors: Ντούση Ελευθερία , Γωνίδα Ελευθερία Ν. , Κιοσέογλου Γρηγόρης
Published: November 2020

The paper presents the adaptation of the Metacognitive Awareness of ReadingStrategies Inventory (MARSI) in the Greek language. MARSI was designed toevaluate the metacognitive awareness and the perceived use of school andacademic content reading strategies by students. The tool measures three subscales: General strategies, problem-solving strategies, and support reading strategies. The present study examined the factorial structure and the psychometric properties of the Greek version of MARSI revealing good internal consistency and testretest reliability. The use of MARSI showed that the Greek students with and without learning difficulties use metacognitive reading strategies, but they score low in support reading strategies.
Η νευροψυχολογική αξιολόγηση στη διαφοροδιάγνωση διπολικής διαταραχής και ΔΕΠΥ σε ενήλικες
Authors: Τζιράκη Σοφία Χ.
Published: November 2020

The clinical phenomenologic similarities between residual Attention Deficit-Hyperactivity Disorder in adults (ADHDa) and Bipolar Disorder (BD) often createdifficulties in distinguishing them during diagnosis. The two disorders do not benefit from the same medication; therefore, limiting a possible diagnostic error is of particular importance for the therapeutic intervention too. The present paper, based on research and bibliographic observations according to which the two entities present certain specific neuropsychological (NP) characteristics that are involved in the functional and psychosocial deficits of the patients, aims to outline the possibilities of employing the neuropsychological assessment (NPA) in the clinical procedure of differential diagnosis. The main conclusion drawn from this critical review is that, despite the difficulty in identifying and quantifying clear differential neurocognitive criteria through research and, thus, in standardizing characteristic NP models that could contribute to the clinical distinction of the two disorders, the NP examination as a detailed analysis, understanding and description of the cognitive problems, can indeed be of use in differential diagnosis of ADHDa and BD, yet individually and always as part of a thorough interdisciplinary clinical evaluation.
Relationship of Internet Addiction with Alexithymia and Childhood’s Perceived Parenting in University Students
Authors: Soranidou Panagiota , Papastylianou Antonia (Dona)
Published: November 2020

Electronic media are integral part of everyday life and undoubtedly facilitate it on multiple levels. Internet is a useful work, knowledge (Papanikolaou, Makri, Magoulas, Chinou, Georgalas & Roussos, 2016), entertainment and information tool, but its limitless range often proves unsafe for the user. The present study, focuses on the relationship among web addiction, alexithymia and childhood’s perceived parenting while controlling for the indirect effect of depression. For the aims of the present study, 206 Greek University students attending Social, Exact Sciences and Ηumanities Departments, mean age 21, filled in a battery of measures; the Young’s Internet Addiction Test IAT (Young, 1998), the Toronto Alexithymia scale (Bagby, Parker & Taylor, 1994) the Center for Epidemiologic Studies Depression scale CES - D (Radloff, 1977), the Parental Bonding Instrument PBI of Parker, Tupling and Brown (1979) and a demographics form. Alexithymia presents significant direct association with Internet addiction, while the factors which mediate this relationship remain unclear. Findings are being discussed towards a possible review of the instruments measuring Internet addiction, as well as towards an approach of electronic media addiction from a different perspective with broader implications in therapeutic practice.
Media psychology and technology special issue: A Discussion
Authors: Roussos Petros
Published: November 2020

Abstract non available
H σχέση των συναισθημάτων με την εστιαζόμενη στον εαυτό προσοχή και την ρύθμιση της συμπεριφοράς
Authors: Παναγιώτου Γεωργία , Αγοραστός Δημήτρης
Published: November 2020

The present study has two aims: First it summarizes current theory and research on the association between self-consciousness/self-focused attention and different aspects of emotions in both typical and clinical populations. Second, it presents some new findings which address this association. As described in the literature, in the process of achieving one’s goals the individual compares oneself with standards and regulates one’s behavior, making behavioral adjustments or changing the goal in order to minimize the difference between one’s current status and one’s goals. During this self-evaluation process, which is an inherent part of self-regulation, attention is focused on the self and can be related to either positive or negative emotions depending on the subjective evaluation regarding the likelihood of achieving one’s goals. In psychopathology this process seems to dysfunction, so that the individual is trapped in a vicious cycle of negative emotion and increased self-focused attention/selfconsciousness. Research suggests that specific emotions, or their dimensions are associated with increased self-focused attention but it remains unclear which these dimensions are and how are related to psychopathology. Τhe findings we present attempt to separate the effects of the basic affective dimensions of valence, arousal and dominance on increased self-focused attention.
Ο ρόλος της βίωσης θετικών συναισθημάτων στην ψυχοθεραπευτική διαδικασία: ανασκόπηση της θεωρητικής και ερευνητικής βιβλιογραφίας
Authors: Σταλίκας Αναστάσιος , Μπούτρη Αλκμήνη
Published: November 2020

In this article we critically present the main theories, models and research findings regarding the role of positive emotions in psychotherapy. In the first part we present an overview of the role of the emotional presence, expression, and experience in psychotherapy and the role of emotions in different psychotherapeutic models. In the second part we focus on the role of humor, joy and love in psychotherapy, while in the last part we present and discuss the Broadenand- build model and its application to psychotherapy theory and practice.
Ιεραρχική Δομή της Αναπτυσσόμενης Προσωπικότητας: Μια Σειρά Ερωτηματολογίων για την Αξιολόγηση των Ατομικών Διαφορών από την Προσχολική Ηλικία ως την Προεφηβεία
Authors: Μπεζεβέγκης Ηλίας , Παυλόπουλος Βασίλης
Published: November 2020

This article presents data on the construction and the hierarchical structure of a series of personality questionnaires for the assessment of child temperament and personality characteristics by parents. In the first phase, free parental descriptions of child personality were collected and classified using a 14-category coding scheme. Then, 100 clusters of conceptually similar descriptors were created within the initial 14 categories. One or two representative items were selected from each cluster to form four trait lists, for children aged 2-4, 5-6, 9-10, and 11-13 years. These preliminary questionnaire versions were administered to 1,817 parents who evaluated their children’s personality characteristics. The underlying structure of parental ratings was examined by applying principal components analyses. This resulted in 4 (3-year-olds) to 5 (6-, 9-, and 12-year-olds) factors and in 12 (3-year-olds) to 15 (6-, 9-, and 12-year-olds) facets of child personality. Alpha coefficients ranged between .76-.96 for the factors, and between .61-.91 for the facets. In their final form, after a psychometric evaluation of their content, the four Questionnaires “Personality Dimensions of Children and Adolescents” (Q-PeDiCA) consist of 92 (3-year-olds), 106 (6-year-olds), 121 (9-year-olds), and 99 (12-year-olds) items, respectively. Several dimensions of the wellknown temperament models are included in the new questionnaires. Moreover, the developmental precursors and deviations from the five-factor model of the adult personality are discussed.
Κατοπτρικοί νευρώνες και Γλώσσα
Authors: Ταχματζίδης Δημήτρης , Μακρής Νίκος
Published: November 2020

Mirror neurons were discovered in 1992 by Giacomo Rizzolatti and his team at the Laboratory of Experimental Psychology at the University of Parma, Italy. This discovery has triggered a debate about the origins of human language by describing an evolutionary transition from gestures to vocal language. This paper presents a brief introduction to the discovery of the mirror neurons, while focusing on their contribution to human action understanding and to the emergence of the human language. It also presents a discussion regarding the existence of mirror neuronsand their functions. Under this scope, a brief criticism to mirror neuron theory and their contribution in human communication is also presented.
Κοινωνικές αξίες, φιλοκοινωνική συμπεριφορά και προσανατολισμός προς τον ατομικισμό και τη συλλογικότητα στην Ελλάδα
Authors: Παπαστυλιανού Αντωνία , Λαμπρίδης Ευθύμιος
Published: November 2020

The present study aimed a. to examine social value priorities, individualism - collectivism orientation and prosocial behavioral tendencies in Greece and, b. to investigate the theoretical conceptualization regarding possible relationships between social value priorities, individualism - collectivism orientation and prosocial behavioral tendencies. Males and females (N = 541) aged 18 to 65 from various places of Greece completed the Social Values Survey (Schwartz, 1992), the Auckland Individualism Collectivism Scale (Shulruf et al., 2011), the Prosocial Tendencies Measure (Carlo & Randall, 2002) as well as a form of socio-demographic information. Social Values types of Self-Direction, Benevolence, Security and Hedonism were found to be considered as the most guiding principles in participants’ lives. Individualism - Collectivism orientation was found to coexist in the answers of the participants although a significant tendency towards Individualism was detected in certain cases. The overall tendency towards performing prosocial behavior was found to be moderate to high, yet the exceeding Atruism type did not conform with the Anonymous type leading to the assumption that prosocial behavior is not clearly spontaneous among the participants, especially since the Compliant and Emotional types were also highly assessed. Results, furthermore provided us with some evidence regarding the association of certain Social Value types to prosocial behavioral tendencies. Specifically, an increase in the prioritization of Benevolence, Universalism, Self-direction and Security was found to be negatively related to the Public type of prosocial behavior. Theoretically remarkable is that an increase in the prioritization of Conformity, Benevolence and Security was found to be positively related to Compliant type of prosocial behavior.