bluuebunny/crossref_metadata_2025 huggingface dataset:
Multidimensional Internet Use, Social Participation, and Depression Among Middle-Aged and Elderly Chinese Individuals: Nationwide Cross-Sectional Study
Authors: Du Xiwang , Liao Jiazhi , Ye Qing , Wu Hong
Published: August 2023

Background

There is growing evidence that the internet has beneficial effects on the mental health of middle-aged and older people (≥45 years), but the evidence is inconclusive, and the underlying mechanisms are less known.

Objective

This study aims to explore the relationship between multidimensional (devices, frequency, and purpose) internet use and depression in middle-aged and elderly Chinese, as well as the mediating effect of social participation. Moreover, this study will explore the moderating effect of the regional informatization development level (RIDL) on the relationships between individual internet use, social participation, and depression.

Methods

Data on 17,676 participants aged 45 years or older were obtained from the China Health and Retirement Longitudinal Study (CHARLS) 2018 data set. The 10-item Center for Epidemiologic Studies Depression Scale (CES-D-10) was used to identify the presence of depression. Logistic regression was used to explore the relationship between each dimension of internet use and depression. Multiple linear regression was used to explore the mediating effect of social participation and the moderating effect of the RIDL.

Results

The results showed that 28.33% (5008/17,676) of the total population had depression. In terms of regional subgroups, respondents living in the western region exhibited the highest proportion of depression (2041/5884, 34.69%). Internet use was negatively associated with depression (odds ratio 0.613, 95% CI 0.542-0.692; P<.001). Various dimensions of internet use positively contributed to individual social participation and reduced individual depression (devices: β=–.170, 95% CI –0.209 to –0.127; frequency: β=–.065, 95% CI –0.081 to –0.047; and purpose: β=–.043, 95% CI –0.053 to –0.031). In addition, the RIDL weakened the relationship between individual-level internet use and social participation (internet use: F74.12,9.82=7.55, P<.001; devices: F51.65/9.88=5.23, P=.005; frequency: F66.74/10.08=6.62, P=.001; and purpose: F66.52/9.78=6.80, P=.001), and negatively moderated the relationship between the frequency of internet use and depression (frequency: F662.67/188.79=3.51, P=.03).

Conclusions

This study found that different dimensions of internet use are associated with lower levels of depression. Social participation partially mediates the association between multidimensional internet use and depression in the eastern, central, and western regions, respectively. Additionally, the RIDL helps individuals further their internet use and social participation, reducing the impact of depression. However, this effect weakens sequentially from the western region to the central region and then to the eastern region.
Evaluating the Feasibility and Acceptance of a Mobile Clinical Decision Support System in a Resource-Limited Country: Exploratory Study
Authors: Ndlovu Kagiso , Stein Nate , Gaopelo Ruth , Annechino Michael , Molwantwa Mmoloki C , Monkge Mosadikhumo , Forrestel Amy , Williams Victoria L
Published: August 2023

Background

In resource-limited countries, access to specialized health care services such as dermatology is limited. Clinical decision support systems (CDSSs) offer innovative solutions to address this challenge. However, the implementation of CDSSs is commonly associated with unique challenges. VisualDx—an exemplar CDSS—was recently implemented in Botswana to provide reference materials in support of the diagnosis and management of dermatological conditions. To inform the sustainable implementation of VisualDx in Botswana, it is important to evaluate the intended users’ perceptions about the technology.

Objective

This study aims to determine health care workers’ acceptance of VisualDx to gauge the feasibility of future adoption in Botswana and other similar health care systems.

Methods

The study’s design was informed by constructs of the Technology Acceptance Model. An explanatory, sequential, mixed methods study involving surveys and semistructured interviews was conducted. The REDCap (Research Electronic Data Capture; Vanderbilt University) platform supported web-based data capture from March 2021 through August 2021. In total, 28 health care workers participated in the study. Descriptive statistics were generated and analyzed using Excel (Microsoft Corp), and thematic analysis of interview transcripts was performed using Delve software.

Results

All survey respondents (N=28) expressed interest in using mobile health technology to support their work. Before VisualDx, participants referenced textbooks, journal articles, and Google search engines. Overall, participants’ survey responses showed their confidence in VisualDx (18/19, 95%); however, some barriers were noted. Frequently used VisualDx features included generating a differential diagnosis through manual entry of patient symptoms (330/681, 48.5% of total uses) or using the artificial intelligence feature to analyze skin conditions (150/681, 22% of total uses). Overall, 61% (17/28) of the survey respondents were also interviewed, and 4 thematic areas were derived.

Conclusions

Participants’ responses indicated their willingness to accept VisualDx. The ability to access information quickly without internet connection is crucial in resource-constrained environments. Selected enhancements to VisualDx may further increase its feasibility in Botswana. Study findings can serve as the basis for improving future CDSS studies and innovations in Botswana and similar resource-limited countries.
Pernikahan di Era Mesir Modern: Sejarah, Tradisi, dan Tantangan.
Authors: Mufauwiq Mukhtar
Published: August 2023

Penelitian ini menganalisis tantangan yang dihadapi oleh masyarakat Mesir dalam konteks pernikahan di era modern dengan mengacu pada beberapa teori yang relevan. Menggunakan pendekatan sejarah dan budaya, penelitian ini mengeksplorasi signifikansi pernikahan di Mesir dan dampak perubahan dalam sikap terhadap peran gender dan pengaruh budaya Barat. Berdasarkan teori-teori sosiologi dan psikologi sosial, penelitian ini membahas perubahan dalam kehidupan berpasangan, dinamika keluarga, dan pergeseran peran serta tanggung jawab suami-istri. Selain itu, teori feminisme digunakan untuk menganalisis tantangan yang dihadapi oleh istri dalam menjalani tuntutan kehidupan yang seringkali bertentangan dengan nilai-nilai tradisional. Dengan menggunakan metode kualitatif, hasil dari penelitian ini menunjukkan bahwa meskipun pernikahan di Mesir mengalami perubahan, institusi pernikahan tetap memainkan peran penting dalam stabilitas pribadi dan keluarga, serta menjadi simbol kedewasaan dan status sosial. Penelitian ini juga memberikan refleksi tentang evolusi pernikahan di Mesir di era modern dan menggarisbawahi pentingnya komunikasi terbuka, saling menghormati, serta kemampuan untuk beradaptasi dalam menghadapi perubahan.
Fixed-Dose Combination Therapy for the Prevention of Cardiovascular Diseases in CKD
Authors: Sepanlou Sadaf G. , Mann Johannes F.E. , Joseph Philip , Pais Prem , Gao Peggy , Sharafkhah Maryam , Roshandel Gholamreza , Yusuf Salim , Malekzadeh Reza ,   on behalf of the Polypill Trialists' Collaboration
Published: August 2023

Background

Fixed-dose combination treatments reduce cardiovascular disease in primary prevention. We aim to explore whether those benefits differ in the presence of CKD.

Methods

We conducted an individual participant data meta-analysis in 18,162 participants on the efficacy and safety of treatment for the primary prevention of cardiovascular disease. Combination therapies consisted of at least two BP-lowering drugs and a statin, with or without aspirin versus placebo or minimal care. Here, we examine the differential effect of fixed-dose combination treatment on the risk of developing cardiovascular disease in participants with a low eGFR (<60 ml/min per 1.73 m2; Chronic Kidney Disease Epidemiology Collaboration formula) compared with a normal eGFR (≥60 ml/min per 1.73 m2). The primary composite outcome was time to first occurrence of a combination of cardiovascular death, myocardial infarction, stroke, or arterial revascularization.

Results

At baseline, the mean level of eGFR was 76 ml/min per 1.73 m2 (SD 17). In total, 3315 (18%) participants had low eGFR at baseline. During a median follow-up of 5 years, among participants with normal eGFR, the primary outcome occurred in 232 (3%) participants in the treatment group compared with 339 (5%) in the control group (hazard ratio, 0.68; 95% confidence interval, 0.57 to 0.81; P < 0.001). In participants with low eGFR, the primary outcome occurred in 64 (4%) participants in the treatment group compared with 130 (8%) in the control group (hazard ratio, 0.49; 95% confidence interval, 0.36 to 0.66; P < 0.001; P for interaction 0.047). The relative risk reduction among participants with low eGFR was larger for combination strategies, including aspirin compared with treatments without aspirin. Apart from dizziness, other side effects did not differ between treatment and control groups, regardless of the stage of their kidney function.

Conclusions

A fixed-dose combination treatment strategy is effective and safe at preventing cardiovascular disease, irrespective of eGFR, but relative and absolute risk reductions are larger in individuals with low eGFR.

Podcast

This article contains a podcast at https://dts.podtrac.com/redirect.mp3/www.asn-online.org/media/podcast/CJASN/2023_11_08_CJN0000000000000251.mp3
International Soft Law Governance of Artificial Intelligence: Advantages, Approaches, and Credibility
Authors: Shuju FU , Aifen XING
Published: August 2023

Given the transnational nature of data and algorithms associated with artificial intelligence, individual countries often face challenges in developing an effective governance system. Ensuring a healthy, stable, and sustainable AI ecosystem requires international communication, cooperation, and interaction. However, in the emerging and fast-changing interdisciplinary field of AI, internationally binding laws like treaties and agreements cannot be easily established overnight. Multilateral negotiations and local consultations are necessary, as each provision must be carefully considered and weighed, a process that is time-consuming and slow in yielding results. Therefore, it is clear that non-coercive soft law methods are necessary to achieve rapid international consensus and facilitate action. Soft law intervention provides practical space in the current landscape of Internet governance and is both necessary and feasible. At the very least, soft law can initiate the process of legalizing Internet governance. The application of soft law can encourage countries to reach some foundational and framework agreements, enabling practical and effective preparations for future, more comprehensive agreements that may be reached.
Analysis of the Relationship between Emotional Intelligence and Mental Health in School Students
Authors: ata Prem Lata , Devi Dr. Treta
Published: August 2023

Nature's most intelligent and spiritually advanced creature is the human person. Everyone has the capacity to think and act spatially. The main aim of the study is Analysis of the relationship between emotional intelligence and mental health in school students. The study design and approach are referred to as the methodology. It is often referred to as the methodology of the research. Researchers looked at the mental health and emotional intelligence of students from rural areas, urban areas, both rural and urban areas, and discovered a significant and positive association between the two factors.
Advanced Management System for Car Driving Schools
Authors: Kannan Gokula , Sreerambabu  , Rajkumar  , Santhosh
Published: August 2023

Abstract: A driving school management system can significantly reduce the workload and ensure the effective use of driving school knowledge resources. Driving instructors have to deal with several learner drivers at the same time. This prevents communication with the learner drivers about their driving lesson schedule or exams. This is an online application for car and scooter driving school registration. This app automates manual tasks by managing all records related to student access, attendance, vehicles, and instructors. It keeps track of all student drivers. The system administrator controls all system modules. The staff of this driving school has to take care of several students at the same time. This leads to problems in communicating with the students about the driving school schedule or the exam. In this there are more driving students than driving instructors. Each learner driver and driving instructor is given a unique username and password. They can log in to the driving school administration system with this ID and password. After logging in, they will see the basic training syllabus available in the portal. Students are also divided into two groups: Resident students and Distance learners. There is also a local tutor and a distance teacher. Local students can register and select a package and time slot, distance students can search for a distance teacher in their area and book a session with an available distance teacher. The location provides a geolocation-based API that allows you to see the current location of the teacher.
Student Education Background Verification for TPGIT College
Authors: Kannan Dinesh , Sreerambabu  , Riyaz Mohammed , Kalidasan
Published: August 2023

Abstract: One of the most fundamental aspects of background checks is an education verification process. Market conditions are becoming increasingly harsh, forcing individuals to resort to any means to get a job. A significant number of job seekers are misrepresenting their qualifications to attract the attention of potential employers. It is not easy to detect unethical acts such as the falsification of studies, fake institutions, or false claims which makes it necessary to carry out background checks. An average of two to 2.5 million students graduate each year in India. It is all the more important to introduce rigorous education verification procedures given such a large influx of graduates. Companies and institutions, since they have their databases for verifying information on individuals, also use third-party education verification services. We are developing and building a new system called TPGIT to check students' educational activities using email logs in this project. TPGIT is an innovative, cloudbased service that automates the student verification process in colleges and universities. For this purpose, incoming emails are extracted and grouped according to the process model they belong to. Then, the emails of each process model are divided into subgroups and assigned a label indicating the type of business activity. These tasks are performed by using an unsupervised learning technique in conjunction with semantic similarity measurement methods. In addition, this method enables the labelling of emails with activity names that can be used for activity detection in new incoming emails, triggering an automatic response to the verifier. The tool is evaluated based on the relevance of the extracted emails.
Human Identification and Obstacle Detection System for Blind
Authors: Bhuvanesh  , Sreerambabu  , Pailochan Nimmy , Kalidasan
Published: August 2023

Abstract: According to the World Health Organization (WHO), there are millions of visually impaired individuals worldwide in detecting obstacles and identifying people. It emphasizes the advancements in information technology and spatial cognition theory for visually impaired individuals as a new opportunity. The prototype proposes a simple and cost-effective solution using artificial vision through an AI-based intelligent system. The system utilizes the Faster Region Convolutional Neural Network (FRCNN) architecture to recognize human and scene objects or obstacles in real-time, even in complex environments. It provides users with comprehensive information about the presence, position, and nature of targets, and uses voice messages to alert blind individuals about obstacles or people nearby. The goal is to create a user-friendly technology that facilitates communication and independence for visually impaired individuals, enabling them to navigate both indoor and outdoor locations effectively.
Vitamin B Kompleksinin Fotodinamik Terapiyle Kolon Kanserine Etkisi
Authors: YURTTAŞ Asiye , ÇINAR Kamil
Published: August 2023

Amaç: Kolon kanserleri, hastanın yaşam kalitesini derinden etkileyen ve çeşitli komplikasyonlarla ilişkili kronik ölümcül bir hastalıktır. Vitamin B kompleksi, gıda takviyesi olarak alındığında olumlu anti-inflamatuar etkiler göstermektedir. Bu çalışma, fotodinamik terapiyle lipozomlu vitamin B kompleksinin kolon kanserlerinde (HCT-116 ve HT-29 hücre hattı) anti-kanser etkisini araştırmayı amaçlamıştır.

Materyal- Metot: Çalışmanın birinci basamağını oluşturan Vitamin B kompleksi lipozom ile kapsüle edildi. Lipozomlu vitamin B kompleksi Zetasizer cihazı ile karakterize edildi. Lipozomlu vitamin B kompleksi MTT (3-4,5-dimetil-tiyazolil-2,5-difeniltetrazolyum bromür) testi ile HCT-116 ve HT-29 hücre hattında % canlılık oranlarına bakılmıştır. Aynı hücre hatlarında vitamin B kompleksinin fotodinamik terapi etkisiyle hangi ölüm yolaklarını seçtiğini göstermek için de akış sitometrisi kullanılarak analiz edilmiştir.

Bulgular: Lipozomlu vitamin B kompleksinin boyutları 100 nm ile 200 nm aralığında değiştiği belirlendi. Lipozomlu vitamin B kompleksi (fotosensitizer) 7,5 J/cm2 ışık dozunda 0,25 mg/ mL'de karanlık deneyinde HCT-116 hücre canlılık yüzdesi %75 iken ışık deneyi sonrası bu oran %47’lere düşmüştür (****p<0.001). 0,5 mg/mL vitamin B kompleksi çözeltisi için yapılan karanlık deneyinde HT-29 hücre canlılık yüzdesi %70 iken ışık deneyi sonrası bu oran %35’lere düşmüştür (****p<0.001). Arzu edilen fotodinamik etkinlik bu sonuçlara daha yakındır. Hücre ölüm yolakları belirleme deneyinde lipozomlanmış vitamin B kompleksinin konsantrasyonu 1mg/mL olarak HCT-116 ve HT-29 hücrelerine uygulanmıştır. HCT-116 hücre hattında %40 oranında apoptoz görülürken HT-29 hücre hattında %60 oranında apoptoz görüldü.

Sonuç: Pazarlanan ilaçları yeniden konumlandırmak, yeni antitümör ilaçları keşfetmek için yeni bir yaklaşım olarak ortaya çıkmıştır. Pazarlanan ilaçlar için yeni kullanım alanlarının geliştirilmesi, yeni anti-tümör ilaçları geliştirmenin etkili ve hızlı yolu olduğu kanıtlanmıştır. Verilerimiz in-vitro olarak bazı kolon kanser türlerinde vitamin B kompleksinin fotodinamik terapiyle kullanımının ümit vaat ettiğini savunmaktadır.
Sinus Ritmindeki Hastalarda Ekokardiyografik Aortik Sertlik Parametreleri ile CHA2DS2-VASc Skoru Arasındaki İlişki
Authors: AKSOY Fatih , BAĞCI Ali , IŞIK İsmail Barkın
Published: August 2023

Amaç: CHA2DS2-VASc skoru, atriyal fibrilasyonda (AF) tromboembolik riski tahmin etmek için kullanılır. Ekokardiyografik aortik sertlik parametreleriyle ilişkisi bilinmemektedir. Mevcut çalışmada CHA2DS2-VASc skoruna göre hesaplanan risk gruplarında aortik sertlik parametrelerinin prediktif değeri araştırılması amaçlanmıştır.
Materyal-Metot: Kardiyolojik kontrol için rutin olarak başvuran toplam 272 hasta (116 kadın, 156 erkek, ort. yaş 61,76±11.5 yıl), CHA2DS2-VASc skorlarına göre iki gruba ayrıldı (skor 0 ve 1) düşük risk ve “≥2”yüksek risk olarak). 272 hastanın 153'ünde yüksek risk vardı.
Bulgular: Aortik gerilim ve aort esneyebilirliği yüksek riskli hastalarda düşük riskli bireylerde olduğundan anlamlı derecede düşüktü (8,9±3,2 ve 14,1±3,9; sırasıyla P<0,001 ve 3,4±2,3 ve 6,9±3,2; P<0,001, sırasıyla). Aortik sertlik indeksi ve elastik modulus yüksek riskli bireylerde düşük riskli bireylere göre anlamlı olarak daha yüksekti (6,5±2,9 ve 3,5±1,4; P<0,001 ve 766,6±374,5 vs. 348,4±175,9; P<0,001, sırasıyla). Aortik gerilim ve aort esneyebilirliği, yüksek risk grubuyla negatif korelasyon gösterdi. Aortik sertlik indeksi ve elastik modülus, yüksek risk grubuyla pozitif olarak korele idi. Çok değişkenli lojistik regresyon analizine göre, elastik modulus, CHA2DS2-VASc skoru açısından yüksek tromboembolik riskin bağımsız belirleyicisiydi.
Sonuç: Bulgularımız, Aort sertliği parametreleri ölçümünün, tromboembolik olaylar gibi kardiyovasküler riski değerlendirmede ek bilgi sağlayabileceğini ve aort sertliği bozuk olan kişilerin, olumsuz kardiyovasküler risk faktörlerini ve gelecekteki kardiyovasküler olayların gelişimini azaltmada daha fazla dikkat etmesi gerektiğini ortaya koymaktadır.
Identifying Pauli spin blockade using deep learning
Authors: Schuff Jonas , Lennon Dominic T. , Geyer Simon , Craig David L. , Fedele Federico , Vigneau Florian , Camenzind Leon C. , Kuhlmann Andreas V. , Briggs G. Andrew D. , Zumbühl Dominik M. , Sejdinovic Dino , Ares Natalia
Published: August 2023

Pauli spin blockade (PSB) can be employed as a great resource for spin qubit initialisation and readout even at elevated temperatures but it can be difficult to identify. We present a machine learning algorithm capable of automatically identifying PSB using charge transport measurements. The scarcity of PSB data is circumvented by training the algorithm with simulated data and by using cross-device validation. We demonstrate our approach on a silicon field-effect transistor device and report an accuracy of 96% on different test devices, giving evidence that the approach is robust to device variability. Our algorithm, an essential step for realising fully automatic qubit tuning, is expected to be employable across all types of quantum dot devices.
Simulación numérica de una columna de agua oscilante para las condiciones de ola del océano Pacífico colombiano
Authors: Parra-Quintero Juan , Rubio-Clemente Ainhoa , Chica Edwin
Published: August 2023

La energía de las olas es una de las fuentes menos explotadas en Colombia. La columna de agua oscilante (OWC, por siglas en inglés) puede ser una tecnología sostenible para generar electricidad en zonas de difícil acceso utilizando la energía disponible en el océano Pacífico. En la actualidad, Colombia carece del desarrollo de estos dispositivos; sin embargo, hay esperanzas centradas en la energía de las olas como alternativa factible para proporcionar energía renovable en las zonas no interconectadas (ZNI) del país. En este trabajo, se pretende simular numéricamente una OWC para las condiciones del océano Pacifico colombiano, por lo que se empleó la dinámica de fluidos computacional a través del programa ANSYS Fluent para modelar una OWC ubicada en la orilla. Esta investigación alcanza la etapa de simulación numérica; sin embargo, puede ser llevada a estudios experimentales a pequeña escala. La eficiencia máxima de la cámara resonante simulada y la velocidad media de la superficie libre de la columna de agua para la geometría estudiada fueron 66.81 % y 0.118 m/s, respectivamente. El análisis de sensibilidad de los factores geométricos que describen la cámara resonante del dispositivo frente a diversas condiciones de mar podría ser de crucial interés para mejorar su eficiencia hidrodinámica.
Caracterización de los procesos en el beneficio del cacao (Theobroma cacao L) en producciones a pequeña escala en el municipio de Guamal del Piedemonte llanero colombiano
Authors: Góngora-Duarte Andrés Felipe , Morales-Espitia Francisco José , Trujillo-González Juan Manuel , Torres-Mora Marco Aurelio
Published: August 2023

La producción de cacao es una de las alternativas productivas en la región del Piedemonte llanero. El proceso de cultivo y beneficio del cacao es fundamental para las familias campesinas, el cual se realiza de manera tradicional. En zonas rurales de municipios productores de la región se evidencia el uso de diferentes sistemas tradicionales, donde el cultivo del cacao cumple un rol fundamental en la resiliencia de los pequeños cacaocultores, desde el punto de vista social y económico. Sin embargo, son escasas las investigaciones sobre los procesos de beneficio de cacao en pequeña escala. El objetivo de la presente investigación fue caracterizar el proceso de beneficio del cacao en producción a pequeña escala del municipio de Guamal, en el Piedemonte llanero de Colombia, teniendo en cuenta las etapas de: cosecha, fermentación, secado y almacenamiento. La información se recolectó mediante la aplicación de entrevistas semiestructuradas, las cuales se llevaron a cabo en las unidades productivas de la zona rural del municipio con un cultivo de cacao menor a cuatro hectáreas, denominados pequeños productores. Los principales resultados mostraron que los pequeños agricultores cuentan con mezclas de variedades en sus cultivos, identificándose un total de ocho variedades o clones; se encontró, además, dos sistemas de fermentación: cajón de madera (82 %) y lona plástica (18 %); tres sistemas de secado: marquesina (64 %), casa Elba (29 %) y lona plástica (7 %). Asimismo, se halló que la fuerza laboral recae sobre los adultos mayores y las mujeres, y en algunas unidades productivas realizan procesos de trasformación de derivados del cacao como: bebidas alcohólicas, nibs de cacao, chocolate de mesa y compostaje. No se evidencia preocupación por la calidad final del grano, debido a que no existe un precio diferencial por implementar buenas prácticas poscosecha.
Risk Assessment of Heavy Metals in Acid Soils Collected from Different Agricultural Systems in the Piedemonte Llanero in Colombia
Authors: Trujillo-González Juan Manuel , García-Bravo Deiver Alexis , Rojas-Peña Jose Ismael , Serrano-Gómez Marlon , Castillo-Monroy Edgar Fernando , Torres-Mora Marco Aurelio , García-Navarro Francisco J. , Jiménez-Ballesta Raimundo
Published: August 2023

Agricultural soils may become polluted by heavy metals as a result of receiving a significant amount of pollutants from different sources of land applications, such as fertilizers, animal manure, sewage sludge, pesticides, and wastewater irrigation. Given that information on the distribution of heavy metals (HMs) in the Piedemonte Llanero of Colombia is still quite limited, the main objectives of this work were to characterize the content of these elements and their potential pollution level in acidic soils under different agricultural systems. The hypothesis is to verify if the type of land use poses an environmental threat. To achieve these goals, the concentrations of seven metals were determined in the soils of three agricultural production systems: oil palm, pastures, and semi-annual crops. Soil contamination was evaluated based on the Geo-Accumulation Index (I-geo), contamination factor (CF), Pollution Load Index (PLI), and Nemerov Integrated Pollution Index (NIPI). One outstanding result was that the average concentrations of HMs in the collected topsoil samples were as follows: Mn (110.5 mg kg-1), Zn (31.93 mg kg-1), Cr (8.85 mg kg-1), Ni (11.68 mg kg-1), Cu (11.28 mg kg-1), Pb (9.42 mg kg-1) and Cd (0.21 mg kg-1). The results obtained from this study provide an estimation of the pollution status of HMs. Agricultural activities, especially the overuse of phosphate fertilizer, were the main source of nutrients across the study area. This information can become a fundamental tool to establish monitoring and follow-up processes for sustainable soil management in the Piedemonte Llanero. In conclusion, the present study highlights and provides specific information in a hyperhumid environment.
O conto infantil como estratégia didática para favorecer a língua escrita em estudantes com deficiência auditiva
Authors: Núñez Bryan Joaquín Arrieta , Guerra Liseth Villar , Castro Javier Barrios
Published: August 2023

Este artigo, baseado em uma proposta de pesquisa, tem como objetivo descrever os diferentes problemas que existem dentro do processo de ensino e aprendizagem da língua escrita em alunos com deficiência auditiva, este processo baseou-se em propor uma estratégia para fortalecê-la e tornar essa experiência algo significativo na criança devido à importância que representa em sua vida o processo de aprendizagem e aquisição da linguagem nos primeiros anos de vida. Como objetivo geral, o favorecimento da linguagem escrita em estuantes com deficiência auditiva foi proposto por meio da história infantil como estratégia didática, consequentemente foram identificadas as barreiras que impedem A aprendizagem de qualidade, a proposta de estratégias desenhadas em torno da necessidade que é estudada e a análise do quanto esse processo favorece a solução do problema apresentado pela população designada para este caso. Este artigo procurou Desenvolver o tema sob uma abordagem descritiva, sendo designado como um estudo de caso sob um paradigma interpretativo de caráter qualitativo, foram elaborados diversos instrumentos que possuem validação a fim de apresentá-los como uma proposta de fortalecimento do processo descrito.
Arquitectura de Computadoras con RISC-V
Authors: Jaramillo Villegas José Alfredo , Zuluaga Bucheli Hernán Mauricio , Sepúlveda Caviedes Camilo
Published: August 2023

La formación en ingeniería de computadoras cumple una función fundamental en la educación en la ciencia de la computación. Esta capacitación proporciona a los estudiantes los conocimientos que necesitan para diseñar, configurar y maximizar las capacidades de los sistemas computacionales. Históricamente, esta área ha sido enseñada con arquitecturas de conjuntos de instrucciones de tipo reducido (RISC) dada la dificultad que conlleva el entendimiento de las arquitecturas de tipo complejo (CISC), tal como su nombre lo indica. En las últimas tres décadas, esta área ha pasado por varias arquitecturas RISC, tales como DLX, MIPS, SPARC y ARM. Sin embargo, ninguna ha permitido una integración vertical totalmente abierta, de libre uso y sin restricciones por licenciamiento. Esta arquitectura RISC-V pretende brindar un estándar moderno que fácilmente pueda cumplir las necesidades pedagógicas en el aula de clase. De igual forma, RISC-V logra brindar la robustez necesaria para cumplir con los requerimientos para su implementación en procesadores para teléfonos inteligentes, tabletas y sistemas embebidos, en donde actualmente domina la arquitectura ARM; y en computadoras portátiles y de escritorio, servidores y supercomputadoras, en donde domina la arquitectura X86-64. Podría proyectarse que en los próximos años el impacto de RISC-V en la arquitectura de computadoras será equivalente al rol que ha jugado Linux en los sistemas operativos.
Symptoms evolution after SARS-CoV-2 infection and measures of home-based care
Authors: Tao Xing-Qiao , Gao Zi-Jie , Zhang Wen , Zhang Ning-Jie , Wu Qing-Chen , Wei Xian , Qiu huan
Published: August 2023

The novel coronavirus (SARS-CoV-2) has caused a global pandemic, which
can cause cough, fever, muscle aches, fatigue and, sore throat. However,
most people do not know how to cope with them so that some patients may
progress to pneumonia and even severe disease. Therefore, it’s crucial
to effectively cope with COVID-19 infection at home to reduce the rate
of hospitalization, ease the burden of healthcare systems, alleviate
patients’ suffering, and shorten the illness duration. In this regard,
we aim to describe the symptom groups of the recently epidemic BF.7
variant strain infection, and summarize previous clinical experience and
expert guidelines, the following home care measures for the five main
symptoms were proposed. We hope that these strategies will serve as a
reference for home care of patients and help them take appropriate
measures to manage their symptoms.
Untitled Document
Authors: Kavitha M.R. , Geetha M.R. , Rajesh T.
Published: August 2023

In today’s world, Free Space Optical (FSO) communication under
atmospheric turbulence continues to be an active area of research and
development across various applications. Through the application of
advanced techniques and technologies, FSO systems strive to achieve
reliable, high-capacity data transmission in challenging atmospheric
conditions. Due to the specific characteristics of gamma-gamma
turbulence, it poses signal fading, scintillation, and link failures
caused by turbulence can lead to service interruptions and impact the
overall connectivity and network performance. However, it requires
careful consideration of the environmental conditions and the use of
appropriate techniques to ensure reliable and high-quality data
transmission. Hence, there is a need to develop a low-complexity
parameter estimation using an improved deep learning technique with low
Bit Error Rate (BER) and low Mean Square Error (MSE). This paper propose
a Hierarchical Attention-Echo State Network (HA-ES Net) model to
estimate the parameters over gamma-gamma turbulence channels in FSO
communications. HA-ES Net model leverages deep learning, attention
mechanisms, and the ESN architecture. In this, the attention mechanism
allows the network to selectively attend to informative channel
characteristics and suppress noise and irrelevant information. Echo
state property helps in learning and capturing the underlying dynamics
of the FSO channel, enabling robust estimation even in the presence of
noise and interference. Hence the hierarchical structure of HA-ES Net
enables the network to learn and model the FSO channel in a more
efficient manner. This reduces the complexity of training the network
compared to other traditional approaches, making it feasible to
implement HA-ES Net for FSO channel estimation. The simulation outcomes
illustrate that the HA-ES Net model achieves strong estimation
performance, characterized by low BER, low MSE, and minimal
computational complexity.
Biotreatment of swine wastewater by mixotrophic Galdieria sulphuraria
Authors: Pan Yali , Ma Zhiwen , Shen Jie , Liang Jia , Yuan Yupeng , Lian Xiao , Sun Yingqiang
Published: August 2023

Biotreatment of swine wastewater via microalgae is an environmentally
sustainable strategy capable to transform nitrogen, phosphorous, and
organic/inorganic carbons into value added products, while microalgal
species with efficient COD and ammonium removal efficiency is lacking,
limiting its practical application. Thermophilic and acidophilic
Galdieria sulphuraria ( G. sulphuraria) are reported to
have high ammonium removal efficiency, while its application in swine
wastewater treatment is rarely reported. Accordingly, mixotrophic
G. sulphuraria has been tested for biotreatment of swine
wastewater. The results indicate that G. sulphuraria can grow
well in swine wastewater with maximum growth rate of 0.72 g/(L.d) when
15 g/L of glucose is added. Maximum COD removal efficiency of 94.8% and
ammonium removal rate of 550.5 mg/(L.d) are observed with 15 g/L of
glucose added. Addition of glucose leads to decreases of lipid, protein
and ash contents, and simultaneous increase of carbohydrates owing to
the varied C/N ratios. The biomass has relatively lower carbon content
of 48.5% with 20 g/L glucose than 49.3% of control, consequently leads
to a relatively lower HHV value of 20.64 MJ.kg .
Above all, mixotrophic G. sulphuraria are promising strategy for
swine wastewater treatment with high energy recovery, potentially
providing an economical strategy for swine wastewater treatment.
IDENTIFICATION OF COLD TOLERANCE AND SOME AGRONOMIC TRAITS OF ADVANCED SAFFLOWER GENOTYPES DEVELOPED BY HYBRIDIZATION
Authors: Culpan Emrullah
Published: August 2023

The development of winter-tolerant safflower genotypes is crucial for
the improvement of global safflower agriculture. The aim of the present
study was to determine the cold tolerance abilities and some
agricultural characteristics of advanced safflower genotypes. For this
purpose, ten advanced safflower genotypes were used in four different
locations. The experimental design was a randomized complete block
design with three replications. Winter survival and agricultural
characters were significantly affected by growing season, location and
genotype. Winter survival varies between 86.43% and 93.91% among the
genotypes, and it was promising for winter sowing. As the average of two
years, the highest oil content (36.25%) was observed in genotype EC21
and it was followed by genotypes EC11 (35.51%) and EC20 (35.49%). As
with the seed yield, the high winter survival of genotypes with high oil
content is highly promising in terms of winter sowing. Safflower should
be grown in winter with mild temperature regions for high seed yield and
sustainable safflower production. Therefore, this study focused on
winter-tolerant genotypes that are superior one in terms of seed yield
and oil content.
PowerPulse: Power Energy Chat Model with LLaMA Model Fine-tuned on Chinese and Power Sector Domain Knowledge
Authors: nong qiong , Yin ChunLin , Du KunPeng , Zhang HongCheng , Yang Li , Yan Bin , Xiang Huang , Wang XiaoBo , Zhang Xuan
Published: August 2023

Recently, Large-scale Language Models (LLMs) such as Chat Generative
Pre-trained Transformer (ChatGPT) and Generative Pre-trained Transformer
4 (GPT-4) have demonstrated remarkable performance in the general
domain. However, Inadaptability in a particular domain have led to
hallucination for these LLMs when responding in specific domain
contexts. The issue has attracted widespread attention, existing
domain-centered fine-tuning efforts have predominantly focused on
sectors like medical, financial, and legal, leaving critical areas such
as power energy relatively unexplored. To bridge this gap, this paper
introduces a novel power energy chat model called PowerPulse. Built upon
the open and efficient foundation language models (LLaMA) architecture,
PowerPulse is fine-tuned specifically on Chinese Power Sector Domain
Knowledge. This work marks the inaugural application of the LLaMA model
in the field of power energy. By leveraging pertinent pre-training data
and instruction fine-tuning datasets tailored for the power energy
domain, the PowerPulse model showcases exceptional performance in tasks
such as text generation, summary extraction, and topic classification.
Experimental results validate the efficacy of the PowerPulse model,
making significant contributions to the advancement of specialized
language models in specific domains.
Additional Evidence for the Relationship Between Type 2 Diabetes and Stroke Through Observational and Genetic Analyses
Authors: Zhang Wenqiang , Zhang Li , Zhu Jingwei , Xiao Chenghan , Cui Huijie , Yang Chao , Yan Peijing , Tang Mingshuang , Wang Yutong , Chen Lin , Liu Yunjie , Zou Yanqiu , Wu Xueyao , Zhang Ling , Yang Chunxia , Yao Yuqin , Li Jiayuan , Liu Zhenmi , Jiang Xia , Zhang Ben
Published: August 2023

While type 2 diabetes mellitus (T2DM) is commonly considered a putative causal risk factor for stroke, the effect of stroke on T2DM remains unclear. The intrinsic link underlying T2DM and stroke has not been thoroughly examined. We aimed to evaluate the phenotypic and genetic relationships underlying T2DM and stroke. We evaluated phenotypic associations using data from the UK Biobank (N = 472,050). We then investigated genetic relationships by leveraging genomic data in European ancestry for T2DM, with and without adjusting (adj) for BMI (T2DM: n = 74,124 case subjects/824,006 control subjects; T2DMadjBMI: n = 50,409 case subjects/523,897 control subjects), and for stroke (n = 73,652 case subjects/1,234,808 control subjects). We performed additional analyses using genomic data in East Asian ancestry for T2DM (n = 77,418 case subjects/356,122 control subjects) and for stroke (n = 27,413 case subjects/237,242 control subjects). Observational analyses suggested a significantly increased hazard of stroke among individuals with T2DM (hazard ratio 2.28 [95% CI 1.97–2.64]), but a slightly increased hazard of T2DM among individuals with stroke (1.22 [1.03–1.45]) which attenuated to 1.14 (0.96–1.36) in sensitivity analysis. A positive global T2DM-stroke genetic correlation was observed (rg = 0.35; P = 1.46 × 10−27), largely independent of BMI (T2DMadjBMI-stroke: rg = 0.27; P = 3.59 × 10−13). This was further corroborated by 38 shared independent loci and 161 shared expression-trait associations. Mendelian randomization analyses suggested a putative causal effect of T2DM on stroke in Europeans (odds ratio 1.07 [95% CI 1.06–1.09]), which remained significant in East Asians (1.03 [1.01–1.06]). Conversely, despite a putative causal effect of stroke on T2DM also observed in Europeans (1.21 [1.07–1.37]), it attenuated to 1.04 (0.91–1.19) in East Asians. Our study provides additional evidence to underscore the significant relationship between T2DM and stroke.

Article Highlights
An Enhancer Within Abcb11 Regulates G6pc2 in C57BL/6 Mouse Pancreatic Islets
Authors: Keller Mark P. , Hawes Emily M. , Schueler Kathryn L. , Stapleton Donnie S. , Mitok Kelly A. , Simonett Shane P. , Oeser James K. , Sampson Leesa L. , Attie Alan D. , Magnuson Mark A. , O’Brien Richard M.
Published: August 2023

G6PC2 is predominantly expressed in pancreatic islet β-cells where it encodes a glucose-6-phosphatase catalytic subunit that modulates the sensitivity of insulin secretion to glucose by opposing the action of glucokinase, thereby regulating fasting blood glucose (FBG). Prior studies have shown that the G6pc2 promoter alone is unable to confer sustained islet-specific gene expression in mice, suggesting the existence of distal enhancers that regulate G6pc2 expression. Using information from both mice and humans and knowledge that single nucleotide polymorphisms (SNPs) both within and near G6PC2 are associated with variations in FBG in humans, we identified several putative enhancers 3′ of G6pc2. One region, herein referred to as enhancer I, resides in the 25th intron of Abcb11 and binds multiple islet-enriched transcription factors. CRISPR-mediated deletion of enhancer I in C57BL/6 mice had selective effects on the expression of genes near the G6pc2 locus. In isolated islets, G6pc2 and Spc25 expression were reduced ∼50%, and Gm13613 expression was abolished, whereas Cers6 and nostrin expression were unaffected. This partial reduction in G6pc2 expression enhanced islet insulin secretion at basal glucose concentrations but did not affect FBG or glucose tolerance in vivo, consistent with the absence of a phenotype in G6pc2 heterozygous C57BL/6 mice.

Article Highlights
Os desafios atuais da universidade:
Authors: Almeida Fernando , Casali Alipio , Dowbor Ladislaw , C. Ronca Antonio Carlos , Santaella Lucia , Veras Maura
Published: August 2023

A era da cultura educacional baseada no livro e na hierárquica transmissão do conhecimento foi gradativamente perdendo a sua hegemonia há mais de um século. O advento da cultura digital em seu estado atual dataficado vem tornando essa perda cada vez mais nítida. Os caminhos da Universidade, nas novas condições de conectividade global, precisam ser redefinidos. Os processos de produção, transmissão e dissemina- ção do conhecimento hoje contam com novos dispositivos sociotécnicos de cooperação e compartilhamento que devem ser explorados tendo em vista renovadas formas de inclusão e de desempenho. Este artigo é fruto de discussões levadas a efeito por um grupo de pesquisadores seniors, com larga experiência de ensino, especialmente no ensino superior, portanto, um grupo preparado para pensar sobre o urgente papel que a univer- sidade precisa assumir no contexto das crescentes transformações.
Desafios da Controladoria em Tempos de Pandemia:
Authors: Paixão Guilherme Vicente da Cruz , Lopes Christianne Calado Vieira de Melo
Published: August 2023

Este artigo teve como objetivo identificar a percepção de um controller sobre os desafios da controladoria em tempos de pandemia, em uma empresa de eletrodomésticos. Sob esse alcance, foi revisada a literatura versando sobre contabilidade gerencial e controladoria como instrumentos para uma boa gestão financeira da empresa. A pesquisa adota uma abordagem predominantemente qualitativa, cuja coleta dos dados utilizou-se da análise da transcrição de uma entrevista realizada, por meio de uma Live, publicada no canal do Youtube, na qual o sujeito pesquisado foi um controller de um grupo de empresas dos setores de eletrodomésticos. O sujeito foi entrevistado por dois diretores de uma empresa de sistemas para soluções em planejamento orçamentário situada no estado de Santa Catarina.  Dessa forma, levando em consideração a importância da controladoria nas atividades empresariais em um cenário de crise econômica e pandemia, os resultados obtidos revelaram que a revisão orçamentária e a gestão de fluxo de caixa são os principais papéis que a controladoria poderá adotar em um momento de crise econômica para assegurar a continuidade dos negócios. Assim, a pesquisa contribui para a discussão acerca da importância e do papel da controladoria como um setor capaz de auxiliar o planejamento orçamentário, o fluxo de caixa e a gestão estratégica da empresa em um cenário econômico de crise e pandemia.
SIMPLIFICATION OF THE REINFORCED CONCRETE ARCHED ROOFING CONSTRUCTION
Authors:   Faculty of Civil Engineering, Georgian Technical University, Georgia, Kvaraia Irakli , Giorgobiani Ioseb ,   Faculty of Civil Engineering, Georgian Technical University, Georgia
Published: August 2023

In this paper, we discuss issues arising in the construction of cast-in-situ reinforced concrete arched roofs and ways to simplify their design. Despite the versatility of existing mold systems in construction, shell-type roofing structures are entirely different from other structural elements widely used in construction practice in terms of their outline and overall dimensions. Therefore, to erect them, it is necessary to build an individual mold system, which would provide the appropriate spatial shape for cast-in-situ reinforced concrete roofing. Due to the scale of shell roofs, the installation of such mold systems is often associated with significant difficulties as it requires a large, bulky structure above the ground surface with the use of load-bearing scaffolding and planking. This results in issues of building individual elements and the entire mold system and accurately placing them in the design position, which can be solved quite easily using the experience gained from similar works. As a demonstration of this, an example of the arched roof construction for the church named after the Mother of God of Iveria, the second largest church in Georgia, was given a few years ago. At the time, the main difficulty was manufacturing and installing wooden arch molds, which was quickly overcome due to considering several practical measures in advance.
Analysis of the Values of Islamic Education in the Pilgrimage Tradition of the Tomb of Inyiak Kiramaik Among Indonesian Islamic Communities
Authors: Ulfah Oktriyeni , Ananda Fauzi , Inayah Faridatul
Published: August 2023

One of the cultures of the Islamic community in Indonesia is to make pilgrimages to places that are considered sacred or also known as traditions. This study aims to analyze the values ​​of Islamic education in the traditions of the community at Inyiak Kiramaik grave. This study uses a qualitative method with a phenomenological approach. Sources of data were taken through in-depth interviews with ten informants consisting of two religious’ leaders, and eight people from the community who always make pilgrimages. The research data was taken by means of individual interviews to strengthen the interview data, the authors also made observations and analyzed using the Milles and Hubberman technique. The results showed three values ​​of Islamic education towards the Inyiak Kiramaik tomb, namely i) increasing faith; ii) preserving the tradition of visiting the tombs; iii) strengthening friendly relations between pilgrims. The results of this study can be used as initial data for future researchers to examine this issue in different contexts and issues.