bluuebunny/crossref_metadata_2025 huggingface dataset:
PANORAMA DOS MÉTODOS QUANTITATIVOS USADOS EM PESQUISAS COM O INSTRUMENTO LIBQUAL, EM INSTITUIÇÕES DE ENSINO SUPERIOR
Authors: Cavalcanti Cláudia Osvaldina dos Passos , Soares Sandro Vieira
Published: April 2023

O objetivo deste artigo é analisar as características metodológicas das pesquisas que utilizaram LibQUAL para avaliação dos serviços, em bibliotecas de instituições de ensino superior, publicadas internacionalmente. Assim, realizou-se uma pesquisa bibliográfica, com técnicas de bibliometria e estatística descritiva, em artigos recuperados por meio do descritor “LibQUAL”, nas bases Scopus e Web of Science. Os resultados revelaram a existência de 39 artigos alinhados com a temática LibQUAL, no contexto de instituições de ensino superior. Desses 39 artigos, 37 utilizaram abordagem quantitativa; 20 utilizaram, para análise dos dados, o software SPSS; e, para a coleta de dados, 27 utilizaram a escala Likert de 9 pontos. O periódico com maior número de publicações foi o Library Philosophy and Practice. Todos os 39 artigos empregaram questionário como instrumento de coleta de dados, sendo que 18 utilizaram amostragem aleatória simples. O tamanho mínimo de amostra encontrado foi de 94 participantes e o máximo de 5.914 respondentes. A contribuição desta pesquisa consiste em atualizar o conhecimento sobre o uso da ferramenta LibQUAL assim como em destacar as características da produção científica usando esta ferramenta no contexto das instituições de ensino, e possibilitando apontar direcionamentos metodológicos para futuros estudos sobre o tema.
Is the Nomenclature of Massive Rotator Cuff Tear Used Correctly? Systematic Review
Authors: Deveci Alper , Dur Hakan , Alkan Erkan
Published: April 2023

Background: The term massive refers to a quantitative measure of the rotator cuff tears. Irreparable rotator cuff tear is indicated by ratings that qualitatively evaluate the repairability of the tendon. These two terms should be considered separately. Methods: Between 2016 and 2022, publications in the last about 5 years were searched from Pubmed and MEDLINE online databases. The search terms (irreparable OR massive) AND (rotator cuff tear), (repairable OR massive) AND (rotator cuff tear), (massive OR retracted) AND (rotator cuff tear), (irreparable OR retracted) AND (rotator cuff tear) ”were used. For each search term, it was checked whether the title of the search term was mentioned in the title of the article, and whether the title and the content were compatible in the studies in which the searched term was mentioned in the title. Results: Of the 934 scanned articles, 69 of them were evaluated in terms of study title and material-method compatibility. 22 articles with the term “massive rotator cuff tear” in the title were identified. It was seen that in 11 of these 22 articles (50%), the title and the material method were compatible and in 11 of them (50%) the title and the content were incompatible, and the term “massive” was used instead of the term “irreparable”. Conclusions: We see that most of the studies on massive tears were actually done to emphasize irreparable tears. Since most of the massive tears are repairable, the quality feature of massive tears, which are in the group that poses a problem, as irreparable rotator cuff tear or massive irreparable rotator cuff tear should be emphasized. Keywords: Rotator cuff tears, Shoulder, Arthroscopy, Ireparable, Massive
The impact of avian IgY antibodies and probiotics supplementation via drinking water on growth and laying performance of 16-week-old layer pullets
Authors: Medina Neil P.L. , Purnamasari Listya , Olarve Joseph P. , Dela Cruz Joseph F.
Published: April 2023

Antibiotics raise an issue concerning the development of antibiotic resistance of some pathogenic bacteria. The use of probiotics and Avian IgY in layer pullet farming is a better way of protecting against pathogenic bacteria and increasing production performance. Supplementation of Avian IgY antibodies and probiotics(Lactobacillus acidophilus, Streptococcus faecium, Bifido bacterium longghum, Bacillus thermophilum) were conducted on 5,724 healthy layer pullets to determine its effect on their growth and laying performance. The supplement was in powder form with a dosage of 100 mg per liter of water for 6 hours. The effect of the supplementation was evaluated by measuring production parameters on growth and laying performance of the layer pullets; there were 3 treatment groups, the control group, Treatment 2 which received 5 days initial supplementation for the first week and then twice every week for 9 weeks and Treatment 3 which received 5 days initial supplementation for the first week and then twice every 2 weeks for 9 weeks. Results showed that the supplementation had significant effects in the age in days when 50% of the total population per treatment laid their first eggs, average number of eggs produced, % Hen day production, % Hen house production, total weight of eggs, and feed conversion efficiency. It also showed that the supplementation is economical and yielded higher profit. On the other hand, the supplementation had no significant effect on the average body weight and mortality count of the layer pullets. The supplementation of Avian IgY antibodies and probiotics in water soluble powder via drinking water with 5 days initial supplementation of Avian IgY antibodies and probiotics for the first week; then twice every 2 weeks for 9 weeks has the greatest effects to increase the production performance and profitability of layers.Keywords:  Avian IgY antibodies, Growth performance, Laying performance, Layer pullets, Probiotics
Gold nanosponges: fascinating optical properties of a unique disorder-dominated system
Authors: Bohm Sebastian , Grunert Malte , Schwarz Felix , Runge Erich , Wang Dong , Schaaf Peter , Chimeh Abbas , Lienau Christoph
Published: April 2023

Nanoporous gold is a three-dimensional bulk material that is percolated with a random network of nanometer-sized ligaments and made by selective corrosion of bimetallic alloys. It has intriguing geometric, catalytic, and optical properties that have fascinated scientists for many decades. When such a material is made into the form of small, 100-nm-sized particles, so-called nanosponges emerge that offer much flexibility in controlling their geometric, electronic, and optical properties. Importantly, these particles act as an antenna for light that can efficiently localize optical fields on a deep subwavelength scale in certain hotspots at the particle surface. This makes such nanosponges an interesting platform for plasmonic sensing, photocatalysis, and surface-enhanced Raman spectroscopy. Since the optical properties of these nanosponges can be controlled to a large degree by tuning their geometry and/or composition, they have attracted increasing attention in recent years. Here, we provide a concise overview of the current state of the art in this field, covering their fabrication, computational modeling, and specifically the linear and nonlinear optical properties of individual and hybrid nanosponges, for example, plasmon localization in randomly disordered hotspots with a size <10nm and a long lifetime with an exceptionally high Purcell factor. The resulting nonlinear optical and photoemission properties are discussed for individual and hybrid nanosponges. The results presented have strong implications for further applications of such nanosponges in photonics and photocatalysis.
Gas composition measurements in randomly distributed and fast moving gas bubbles in two-phase fluids
Authors: Kim Seonwoong , Choi Jongwun , Park Hyungmin , Yoon Taekeun , Do Hyungrok
Published: April 2023

Gas composition in randomly distributed and fast-moving bubbles was optically measured aided by laser-induced breakdown spectroscopy (LIBS). Laser pulses were focused at a point in a stream of bubbles to induce plasmas for the LIBS measurements. The distance between the laser focal point and liquid-gas interface, or ‘depth,’ plays a major role in determining the plasma emission spectrum in two-phase fluids. However, the ‘depth’ effect has not been investigated in previous studies. Therefore, we evaluated the ‘depth’ effect in a calibration experiment near a still and flat liquid-gas interface using proper orthogonal decomposition, and a support vector regression model was trained to exclude the influence of the interfacing liquid and extract gas composition information from the spectra. The gaseous molecular oxygen mole fraction in the bubbles was accurately measured under realistic two-phase fluid conditions.
Periodic surface structure of 4H-SiC by 46.9 nm laser
Authors: An Haojie , Wang Jinshi , Cui Huaiyu , Fang Fengzhou
Published: April 2023

This paper presents an experimental study on the laser-induced atomic and close-to-atomic scale (ACS) structure of 4H-SiC using a capillary-discharged extreme ultraviolet (EUV) pulse of 46.9 nm wavelength. The modification mechanism at the ACS is investigated through molecular dynamics (MD) simulations. The irradiated surface is measured via scanning electron microscopy and atomic force microscopy. The possible changes in the crystalline structure are investigated using Raman spectroscopy and scanning transmission electron microscopy. The results show that the stripe-like structure is formed due to the uneven energy distribution of a beam. The laser-induced periodic surface structure at the ACS is first presented. The detected periodic surface structures with a peak-to-peak height of only 0.4 nm show periods of 190, 380, and 760 nm, which are approximately 4, 8, and 16 times the wavelength. In addition, no lattice damage is detected in the laser-affected zone. The study shows that the EUV pulse is a potential approach for the ACS manufacturing of semiconductors.
High-speed feedback based wavefront shaping for spatiotemporal enhancement of incoherent light through dynamic scattering media
Authors: Hsieh Chao-Mao , Malik Mohammad O. A. , Liu Quan
Published: April 2023

Feedback-based wavefront shaping is a promising and versatile technique for enhancing the contrast of a target signal for both coherent and incoherent light through a highly scattering medium. However, this technique can fail for a dynamic sample with a short correlation time. So far, most proposed methods for high-speed wavefront shaping can only directly enhance the intensity of coherent light but not incoherent light. Here we try to fill this gap to directly enhance incoherent light with high speed, such as fluorescence, which is essential in extending wavefront shaping to biomedical applications. For this purpose, we develop a technique based on a single acousto-optic deflector (AOD) with field-programmable gate array (FPGA) acceleration for spatiotemporal focusing within milliseconds. With the digital time gating of the feedback signal, spatiotemporal focusing of laser light with high contrast can be formed behind dynamic scattering media in milliseconds resulting in fluorescence enhancement. Furthermore, FPGA-based wavefront shaping is shown to effectively enhance fluorescence directly behind dynamic samples with short correlation times.
Quantum dot materials for mid-IR photodetection: opinion
Authors: Song Haemin , Tischenko Yadviga , Wasserman Daniel , Jeong Kwang Seob
Published: April 2023

In this opinion we trace the evolution of the quantum dot mid-infrared photodetector, from epitaxially-grown self-assembled quantum dot detectors, to a new generation of colloidal nano-crystal based devices. We opine on the advantages and challenges associated with these colloidal quantum dot materials and discuss their potential for commercial device applications.
Broadband fluorescence and lasing: the role of the chemical potential of light
Authors: Muys Peter
Published: April 2023

We model broadband fluorescence as transitions between two bands of an active medium where the sublevels in the individual bands each follow a Boltzmann distribution. The Einstein equations describing the evolution of two levels, are extended for this purpose to describe two bands. We derive a new expression for the chemical potential of photons by imposing Bose-Einstein statistics to our results. We describe for the first time the exact relationship between chemical potential, excitation potential and the zero-phonon energy. We also derive the gain coefficient and show that lasing is not possible in a two-band system. In summary, a two-band model behaves in many aspects similar to a two-level model.
Gre factors help Salmonella adapt to oxidative stress by improving transcription elongation and fidelity of metabolic genes
Authors: Kant Sashi , Till James Karl A. , Liu Lin , Margolis Alyssa , Uppalapati Siva , Kim Ju-Sim , Vazquez-Torres Andres
Published: April 2023

Detoxification, scavenging, and repair systems embody the archetypical antioxidant defenses of prokaryotic and eukaryotic cells. Metabolic rewiring also aids with the adaptation of bacteria to oxidative stress. Evolutionarily diverse bacteria combat the toxicity of reactive oxygen species (ROS) by actively engaging the stringent response, a stress program that controls many metabolic pathways at the level of transcription initiation via guanosine tetraphosphate and the α-helical DksA protein. Studies herein withSalmonellademonstrate that the interactions of structurally related, but functionally unique, α-helical Gre factors with the secondary channel of RNA polymerase elicit the expression of metabolic signatures that are associated with resistance to oxidative killing. Gre proteins both improve transcriptional fidelity of metabolic genes and resolve pauses in ternary elongation complexes of Embden–Meyerhof–Parnas (EMP) glycolysis and aerobic respiration genes. The Gre-directed utilization of glucose in overflow and aerobic metabolism satisfies the energetic and redox demands ofSalmonella, while preventing the occurrence of amino acid bradytrophies. The resolution of transcriptional pauses in EMP glycolysis and aerobic respiration genes by Gre factors safeguardsSalmonellafrom the cytotoxicity of phagocyte NADPH oxidase in the innate host response. In particular, the activation of cytochromebdprotectsSalmonellafrom phagocyte NADPH oxidase-dependent killing by promoting glucose utilization, redox balancing, and energy production. Control of transcription fidelity and elongation by Gre factors represent important points in the regulation of metabolic programs supporting bacterial pathogenesis.
Mathematical modeling of plus-strand RNA virus replication to identify broad-spectrum antiviral treatment strategies
Authors: Zitzmann Carolin , Dächert Christopher , Schmid Bianca , van der Schaar Hilde , van Hemert Martijn , Perelson Alan S. , van Kuppeveld Frank J. M. , Bartenschlager Ralf , Binder Marco , Kaderali Lars
Published: April 2023

Plus-strand RNA viruses are the largest group of viruses. Many are human pathogens that inflict a socio-economic burden. Interestingly, plus-strand RNA viruses share remarkable similarities in their replication. A hallmark of plus-strand RNA viruses is the remodeling of intracellular membranes to establish replication organelles (so-called “replication factories”), which provide a protected environment for the replicase complex, consisting of the viral genome and proteins necessary for viral RNA synthesis. In the current study, we investigate pan-viral similarities and virus-specific differences in the life cycle of this highly relevant group of viruses. We first measured the kinetics of viral RNA, viral protein, and infectious virus particle production of hepatitis C virus (HCV), dengue virus (DENV), and coxsackievirus B3 (CVB3) in the immuno-compromised Huh7 cell line and thus without perturbations by an intrinsic immune response. Based on these measurements, we developed a detailed mathematical model of the replication of HCV, DENV, and CVB3 and showed that only small virus-specific changes in the model were necessary to describe the in vitro dynamics of the different viruses. Our model correctly predicted virus-specific mechanisms such as host cell translation shut off and different kinetics of replication organelles. Further, our model suggests that the ability to suppress or shut down host cell mRNA translation may be a key factor for in vitro replication efficiency, which may determine acute self-limited or chronic infection. We further analyzed potential broad-spectrum antiviral treatment options in silico and found that targeting viral RNA translation, such as polyprotein cleavage and viral RNA synthesis, may be the most promising drug targets for all plus-strand RNA viruses. Moreover, we found that targeting only the formation of replicase complexes did not stop the in vitro viral replication early in infection, while inhibiting intracellular trafficking processes may even lead to amplified viral growth.
Estimating the health impacts of sugar-sweetened beverage tax for informing policy decisions about the obesity burden in Vietnam
Authors: Nguyen Duyen Thuy , Hoang Minh Van , Dao Son , Do Phuong Hong , Nguyen Quang Dinh , Jewell Jo , Amies-Cull Ben , Muthu Maharajan , Hoang Ly-Na , Le Thu Thi , Nguyen An Thi , Tran Bao Quoc , O’Neill Ciaran
Published: April 2023

Background

Taxation on sugar-sweetened beverages (SSBs) has been adopted in more than 40 countries but remained under discussion in Vietnam. This study aimed to estimate the health impacts of different SSBs tax plans currently under discussion to provide an evidence base to inform decision-making about a SSBs tax policy in Vietnam.

Method & findings

Five tax scenarios were modelled, representing three levels of price increase: 5%, 11% and 19–20%. Scenarios of the highest price increase were assessed across three different tax designs: ad valorem, volume-based specific tax & sugar-based specific tax. We modelled SSBs consumption in each tax scenario; how this reduction in consumption translates to a reduction in total energy intake and how this relationship in turn translates to an average change in body weight and obesity status among adults by applying the calorie-to weight conversion factor. Changes in type 2 diabetes burden were then calculated based on the change in average BMI of the modelled cohort. A Monte Carlo simulation approach was applied on the conversion factor of weight change and diabetes risk reduction for the sensitivity analysis. We found that the taxation that involved a 5% price increase gave relatively small impacts while increasing SSBs’ price up to 20% appeared to impact substantially on overweight and obesity rates (reduction of 12.7% and 12.4% respectively) saving 27 million USD for direct medical cost. The greatest reduction was observed for overweight and obesity class I. The decline in overweight and obesity rates was slightly higher for women than men.

Conclusion

This study supports the SSB tax policy in pursuit of public health benefits, especially where the tax increase involves around a 20% price increase. The health benefit and revenue gains were evident across all three tax designs with the specific tax based on sugar density achieving greatest effects.
Recurrence of post-term pregnancy and associated factors among women who delivered at Kilimanjaro Christian Medical Centre in northern Tanzania: A retrospective cohort study
Authors: Mitao Modesta , Mwita Winfrida C. , Antony Cecilia , Adinan Hamidu , Shayo Benjamin , Amour Caroline , Mboya Innocent B. , Mahande Michael Johnson
Published: April 2023

Background

Post-term pregnancy is a health problem of clinical importance and; tends to recur in subsequent pregnancies. Maternal age, height, and male fetal sex are risk factors associated with Post-term pregnancy. The study aimed to determine the recurrence risk of post-term pregnancy and associated factors among women delivered at KCMC referral hospital.

Methodology

This retrospective cohort study used KCMC zonal referral hospital medical birth registry cohort data for 43472 women delivered between 2000 and 2018. Data were analyzed using STATA version 15 software. Log-binomial regression with robust variance estimator determined the factors associated recurrence of post-term pregnancy adjusted for other factors.

Results

A total of 43472 women were analyzed. The proportion of post-term pregnancy was 11.4%, and the recurrence was 14.8%. The recurrence risk of post-term pregnancy was increased when a woman had a history of previous post-term pregnancy (aRR: 1.75; 95%CI: 1.44, 2.11). Advanced maternal age, i.e., ≥35years (aRR: 0.80; 95%CI: 0.65, 0.99), having secondary and higher education (aRR: 0.8; 95%CI: 0.66, 0.97), and being employed (aRR: 0.68; 95%CI: 0.55, 0.84) decreased the recurrence risk of post-term pregnancy. Women with recurrence of post-term pregnancy had a higher risk of delivering newborns weighed ≥4000gm (aRR: 5.05; 95% CI: 2.80, 9.09).

Conclusion

Post-term pregnancy is associated with recurrence risk in subsequent pregnancies. A history of previous post-term pregnancy is associated risk factor and these women are at increased risk of delivering newborns weighed ≥4000gm. Clinical counselling of women at risk of post-term pregnancy and timely management is recommended to prevent adverse neonatal and maternal outcomes.
Evaluation of effectiveness and improvement factors of occupational health and safety management system in the Republic of Korea Navy based on AHP-entropy and IPA
Authors: Lee Sang ji , Choi Yun-Hee , Huh Da-An , Yoon Seok Joon , Moon Kyong Whan
Published: April 2023

The Republic of Korea Navy (ROKN) has applied Occupational Health and Safety Management System (OHSMS), but the effectiveness of OHSMS is being questioned due to continuous industrial accidents that continue to occur. Although OHSMS, which has been generally applied in enterprises, has more potential for improper implementation in the military, there are few studies on OHSMS in the military. Therefore, this study verified the effectiveness of OHSMS in the ROKN and derived improvement factors. This study was conducted in a two-step process. First, we surveyed 629 workers at the ROKN workplaces to confirm the effectiveness of OHSMS by comparing occupational health and safety (OHS) efforts according to whether OHSMS was applied and the period of application. Second, 29 naval OHSMS experts evaluated the factors for improving OHSMS using two decision-making tools: Analytic Hierarchy Process (AHP)-entropy and Importance-Performance Analysis (IPA). The study results indicate that the OHS efforts of OHSMS-applied workplaces were similar to that of unapplied. Also, no better OHS efforts were identified in workplaces with more extended OHSMS application periods. There were five improvement factors of OHSMS applied to the ROKN workplaces, with the highest weight in the following order: consultation and participation of workers; resources; competence; hazard identification and risk assessment; and organizational roles, responsibilities, and authorities. The effectiveness of OHSMS in the ROKN was insufficient. Therefore, the ROKN needs focused improvement efforts on the five requirements to implement OHSMS practically. These results can be helpful information for the ROKN to apply OHSMS more effectively for industrial safety.
Conditional permeabilization of the P. falciparum plasma membrane in infected cells links cation influx to reduced membrane integrity
Authors: Sylla Mariame , Gupta Ankit , Shao Jinfeng , Desai Sanjay A.
Published: April 2023

The intracellular human malaria parasite, Plasmodium falciparum, uses the PfATP4 cation pump to maintain Na+ and H+ homeostasis in parasite cytosol. PfATP4 is the target of advanced antimalarial leads, which produce many poorly understood metabolic disturbances within infected erythrocytes. Here, we expressed the mammalian ligand-gated TRPV1 ion channel at the parasite plasma membrane to study ion regulation and examine the effects of cation leak. TRPV1 expression was well-tolerated, consistent with negligible ion flux through the nonactivated channel. TRPV1 ligands produced rapid parasite death in the transfectant line at their activating concentrations, but were harmless to the wild-type parent. Activation triggered cholesterol redistribution at the parasite plasma membrane, reproducing effects of PfATP4 inhibitors and directly implicating cation dysregulation in this process. In contrast to predictions, TRPV1 activation in low Na+ media accentuated parasite killing but a PfATP4 inhibitor had unchanged efficacy. Selection of a ligand-resistant mutant revealed a previously uncharacterized G683V mutation in TRPV1 that occludes the lower channel gate, implicating reduced permeability as a mechanism for parasite resistance to antimalarials targeting ion homeostasis. Our findings provide key insights into malaria parasite ion regulation and will guide mechanism-of-action studies for advanced antimalarial leads that act at the host-pathogen interface.
Working from home and subsequent work outcomes: Pre-pandemic evidence
Authors: Chen Ying , Weziak-Bialowolska Dorota , Lee Matthew T. , Bialowolski Piotr , Cowden Richard G. , McNeely Eileen , VanderWeele Tyler J.
Published: April 2023

Frequent working from home (WFH) may stay as a new work norm after the COVID-19 pandemic. Prior observational studies on WFH and work outcomes under non-pandemic circumstances are mostly cross-sectional and often studied employees who worked from home in limited capacity. To provide additional insights that might inform post-pandemic work policies, using longitudinal data collected before the COVID-19 pandemic (June 2018 to July 2019), this study aims to examine the associations between WFH and multiple subsequent work-related outcomes, as well as potential modifiers of these associations, in a sample of employees among whom frequent or even full-time WFH was common (N= 1,123,Meanage= 43.37 years). In linear regression models, each subsequent work outcome (standardized score was used) was regressed on frequencies of WFH, adjusting for baseline values of the outcome variables and other covariates. The results suggested that WFH for 5 days/week versus never WFH was associated with subsequently less work distraction (ß = -0.24, 95% CI = -0.38, -0.11), greater perceived productivity/engagement (ß = 0.23, 95% CI = 0.11, 0.36), and greater job satisfaction (ß = 0.15, 95% CI = 0.02, 0.27), and was associated with subsequent work-family conflicts to a lesser extent (ß = -0.13, 95% CI = -0.26, 0.004). There was also evidence suggesting that long work hours, caregiving responsibilities, and a greater sense of meaningful work can all potentially attenuate the benefits of WFH. As we move towards the post-pandemic era, further research will be needed to understand the impacts of WFH and resources for supporting employees who work from home.
Circulating miR-20b-5p and miR-330-3p are novel biomarkers for progression of atrial fibrillation: Intracardiac/extracardiac plasma sample analysis by small RNA sequencing
Authors: Harada Masahide , Okuzaki Daisuke , Yamauchi Akemi , Ishikawa Shiho , Nomura Yoshihiro , Nishimura Asuka , Motoike Yuji , Koshikawa Masayuki , Hitachi Keisuke , Tsuchida Kunihiro , Amano Kentaro , Maekawa Atsuo , Takagi Yasushi , Watanabe Eiichi , Ozaki Yukio , Izawa Hideo
Published: April 2023

Background

Circulating microRNAs (miRNAs, miR) have been considered as biomarkers reflecting the underlying pathophysiology in atrial fibrillation (AF). Nevertheless, miRNA expression in the peripheral blood samples might not reflect a cardiac phenomenon since most miRNAs are expressed in numerous organs. This study aimed to identify the cardiac-specific circulating miRNAs as biomarkers for AF.

Methods

Plasma samples were obtained from a luminal coronary sinus catheter (CS, cardiac-specific samples) and femoral venous sheath (FV, peripheral samples) in patients with AF and paroxysmal supraventricular tachycardia (control, CTL) undergoing catheter ablation. The circulating miRNA profiles were analyzed by small RNA sequencing. Differently expressed miRNAs between AF and CTL were identified in each sample of the CS and FV; miRNAs exhibiting similar expression patterns in the CS and FV samples were selected as candidates for cardiac-specific biomarkers. The selected miRNAs were related to the outcome of catheter ablation of AF.

Results

Small RNA sequencing detected 849 miRNAs. Among the top 30 most differently expressed miRNAs between AF and CTL, circulating hsa-miR-20b-5p, hsa-miR-330-3p, and hsa-miR-204-5p had a similar pattern in the CS and FV samples. Another set of peripheral blood samples was obtained from AF patients undergoing catheter ablation (n = 141). The expression of the miR-20b-5p and miR-330-3p, but not the miR-204-5p, negatively correlated with the echocardiographic left-atrial dimension and was decreased in patients with AF recurrence as compared to those without AF recurrence during a 1-year follow-up.

Conclusion

Circulating miR-20b-5p and miR-330-3p can be cardiac-specific biomarkers for atrial remodeling progression and arrhythmia recurrence after catheter ablation in AF patients.
A hydrogel model of the human blood-brain barrier using differentiated stem cells
Authors: Singh Nandita Rahatekar , Gromnicova Radka , Brachner Andreas , Kraev Igor , Romero Ignacio A. , Neuhaus Winfried , Male David
Published: April 2023

An in vitro model of the human blood-brain barrier was developed, based on a collagen hydrogel containing astrocytes, overlaid with a monolayer of endothelium, differentiated from human induced pluripotent stem cells (hiPSCs). The model was set up in transwell filters allowing sampling from apical and basal compartments. The endothelial monolayer had transendothelial electrical resistance (TEER) values >700Ω.cm2 and expressed tight-junction markers, including claudin-5. After differentiation of hiPSCs the endothelial-like cells expressed VE-cadherin (CDH5) and von-Willebrand factor (VWF) as determined by immunofluorescence. However, electron microscopy indicated that at set-up (day 8 of differentiation), the endothelial-like cells still retained some features of the stem cells, and appeared immature, in comparison with primary brain endothelium or brain endothelium in vivo. Monitoring showed that the TEER declined gradually over 10 days, and transport studies were best carried out in a time window 24-72hrs after establishment of the model. Transport studies indicated low permeability to paracellular tracers and functional activity of P-glycoprotein (ABCB1) and active transcytosis of polypeptides via the transferrin receptor (TFR1).
The Power of Website and Social Media for Strengthening Brand Image, E-WoM, and Purchase Decision
Authors: Nurhadi Mochamad , Suryani Tatik , Fauzi Abu Amar
Published: April 2023

Nowadays, it becomes intriguing to observe the use of websites and social media by SMEs to market their products, especially in terms of seeing customer behavior. Some previous research found the effect of social media on attitude and consumer behaviors area, but less of the focus on website and social media quality and the effect on brand awareness, brand image, E-WoM, and purchase decision and the relationship among these concepts. This research examines the effect of websites and social media from the perspective of quality dimensions on brand awareness and the influence of brand awareness, E-WoM, and brand image on purchase decisions. In addition, this study has conducted purposive sampling for the 397 respondents who had transacted through the SMEsâ€™ website or social media in two major cities in Indonesia: Jakarta and Surabaya. The PLS-SEM analysis technique was conducted in this study. The result found that there is a positive influence of website quality and social media quality on brand awareness, as well as the influence of brand awareness on E-WoM, brand image, and purchase decisions. In addition, this study also found the influence of E-WoM and brand image on purchase decisions. The findings suggest that it is very important for SMEs to formulate a strategy for improving the quality of their website and social media to strengthen their brand awareness of consumers.
Poligami sebagai Perkawinan Abnormal: Kajian terhadap Syariat Islam
Authors: Nasrulloh Muhammad , Witro Doli
Published: April 2023

Polarisasi poligami dewasa ini menyeruak di permukaan. Hal ini ditengarai oleh pihak-pihak yang mengkampanyekan poligami dengan massif. Secara tidak sehat, Al-Quran dan Hadis dijadikan alat guna membungkus kampanye tersebut seolah poligami itu ‘Islami’. Akibatnya timbul paradoks, di mana sebagian orang berasumsi bahwa Islam agama yang pro dan mendukung poligami. Fakta demikian perlu diluruskan mengingat secara prinsip, agama Islam menjunjung tinggi penghormatan dan keadilan atas sesama makhluk Tuhan. Tidak boleh ada superioritas atas satu pihak yang berakibat memarginalkan pihak lain. Oleh karena itu, penelitian ini berusaha membedah fikih poligami dalam Islam bagaimana sesungguhnya konteks poligami berlaku dan apakah benar Islam mendukung hal tersebut. Penelitian ini menggunakan kajian normatif dengan pendekatan komprehensif guna menghasilkan konklusi yang akurat dan valid. Hipotesa kajian ini hendak membangun pemahaman bahwa poligami adalah pernikahan yang layak dipakai sebagai alternatif dengan berbagai fakta di antaranya secara prinsip fikih tidak menganjurkan poligami. Ayat poligami tidak bermakna wajib namun kebolehan, poligami Rasulullah s.a.w. bukan karena hasrat, hikmah pernikahan kontradiksi dengan poligami serta pendapat dari beberapa cendikiawan Muslim menyangkut persoalan poligami. Sejurus dengan temuan tersebut, poligami layak diperbincangkan pada ranah ‘abnormal’ dimana tidak semua kondisi praktik demikian patut dilakukan.[The polarization of polygamy is currently on the surface. This is suspected by those who are campaigning for polygamy. Unhealthily, Al-Quran and Hadith are used as tools to wrap the campaign as if polygamy is “Islamic” Polygamy, Sharia, Alternative. The result is a paradox, where some people assume that Islam is a pro and supports polygamy. This fact needs to be straightened out considering that the Islamic religion upholds respect and justice for fellow divine beings in principle. There must be no superiority over one party, which results in the marginalization of the other. Therefore, this study seeks to dissect the polygamy sharia in Islam, how the context of polygamy applies and whether Islam supports it. This study uses a normative study with a comprehensive approach to producing accurate and valid conclusions. This study’s hypothesis is to understand that polygamy is alternative fikih with various facts, including in principle that jurisprudence does not advocate polygamy. The verse polygamy does not mean obligatory but permissible, polygamy the Prophet s.a.w. not because of the passion, wisdom of marriage and polygamy, and some Muslim scholars’ opinions. In line with these findings, polygamy deserves to be discussed in the realm of ‘abnormal’ where not all practice conditions are appropriate.]
Eksploitasi Dan Kekerasan Terhadap Perempuan Dalam Konflik Suriah Pendekatan Hermeneutika Feminis Amina Wadud
Authors: Derajat Anna Zakiah , Kurniawan Toni
Published: April 2023

Dalam agama apa pun, perempuan akan menjadi sasaran eksploitasi dan diskriminasi para penafsir fundamental. Ketimpangan peran sosial yang dilihat dari aspek gender selalu mempertahankan dalih-dalih doktrin agama, serta mempertahankan budaya masyarakat yang patriarki. Tentu saja hal itu merugikan perempuan dan menguntungkan kelas-kelas tertentu dalam masyarakat. Sekitar 76% dari tahanan Suriah adalah perempuan. Selama dalam tahanan, perempuan Suriah mengalami kekerasan berbasis gender, hal ini tentu berkaitan erat dengan adanya deminasi laki-laki yang dilanggengkan di negara tersebut. Hal ini sangat kontradiktif dengan pandangan Amina Wadud. Wadud berpendapat bahwa laki-laki dan perempuan berkedudukan yang sama rata, sehingga tidak ada timpang-tindih di antara keduanya. Hal ini sesuai dengan penafsirannya pada QS. An-Nisa ayat 34. Ada tiga kunci yang tertera dalam ayat tersebut, yaitu pertama, qanita>t. Kedua, d}araba.  Ketiga, t}a'at. Tulisan ini ingin menegaskan kembali bahwa agama Islam memang dilahirkan dengan tujuan untuk membebaskan manusia, baik laki-laki maupun perempuan dari segala sistem yang mengekangnya. Dengan mengamalkan dan menegakkan nilai-nilai kemanusiaan, seperti kesetaraan dan keadilan berbasis gender di Negara Suriah. Maka dari itu, adanya tulisan ini berusaha untuk mengungkap permasalahan terkait eksploitasi dan kekerasan terhadap perempuan Suriah dengan menggunakan perspektif hermeneutika feminis Amina Wadud.
 
[In any religion, women will be the target of exploitation and discrimination of fundamental interpreters. Inequality of social roles seen from the aspect of gender always maintains the pretext of religious doctrine, and maintains a patriarchal culture of society. Of course it harms women and benefits certain classes in society. About 76% of Syrian restaurants are women. While in detention, Syrian women experience gender-based violence, this is of course closely related to the existence of male demination that is perpetuated in the country. This is very contradictory to the view of Amina Wadud. Wadud is of the opinion that men and women are equal, so that there is no overlap between the two. This is in accordance with its activities in QS. An-Nisa verse 34. There are three keys listed in the verse, namely first, qanita>t. Second, d}araba. Third, t}a'at. This paper wants to reiterate that the religion of Islam was indeed born with the aim of preserving humans, both men and from all systems that restrain it. By practicing and improving human values, such as experience and gender-based justice in Syria. Therefore, this paper seeks to uncover problems related to exploitation and violence against Syrian women by using the feminist hermeneutic perspective of Amina Wadud.]
Hak Finansial Perempuan Dalam Keluarga Menurut Hukum Keluarga Islam Di Indonesia
Authors: Sulistiani Siska Lis , Nurrachmi Intan
Published: April 2023

Artikel ini bertujuan untuk mengetahui sejauh mana hukum Islam dan hukum positif yang berlaku di Indonesia mengatur pemenuhan hak-hak finansial wanita dalam keluarga, seperti menjelang pernikahan, setelah pernikahan dan pasca perceraian. Hak wanita sebagai istri dan seorang ibu dalam keluarga banyak disepelekan. Terkait hak terkait finansial dalam lingkup keluarga, yang biasa diketahui oleh masyarakat terbatas pada nafkah kehidupan secara umum. Namun sesungguhnya ada hak finansial lain yang dimiliki perempuan dalam keluarga. Penelitian ini merupakan penelitian kualitatif dengan pendekatan yuridis normatif dengan menggunakan jenis dan sumber data hukum primer dan sekunder berupa Al-Qur’an , hadis, peraturan perundang-undangan dan artikel ilmiah terkait. Hasil dari penelitian ini adalah hak finansial wanita dalam keluarga sangat diperhatikan dalam hukum keluarga Islam di Indonesia, baik posisinya sebagai calon istri, istri, ibu maupun sebagai istri yang telah dicerai, diantaranya hak mahar, hak upah dalam masa menyusui, hak nafkah, hak waris, hak nafkah iddah, hak mut’ah bagi yang diceraikan, dan harta bersama. Keseimbangan atas pelaksanaan kewajiban dan pemenuhan hak menjadi unsur penting dalam menjaga stabilitas dan kebahagiaan keluarga.
[This study aims to determine how the Islamic law and positive law in Indonesia regulate the fulfillment of women's financial rights in the family, such as before marriage, after marriage and after divorce. The rights of women as wives and mothers in the family are often underestimated. Regarding the financial rights in the family sphere, what is commonly known by the public is limited to a living life in general. But actually, there are other financial rights that women have in the family. This research is a qualitative research with a normative juridical approach by using primary and secondary types and sources of legal data in the form of the Qur'an, hadith, statutory regulations and related scientific articles. The results of this study are that the financial rights of women in the family are very detail and specific in Islamic family law in Indonesia, both in their position as prospective wives, wives, mothers and as wives who have been divorced, including dowry rights, wage rights during breastfeeding, livelihood rights, inheritance rights, the right of iddah maintenance, the right of mut'ah for those who are divorced, and joint property. The balance of the implementation of obligations and the fulfillment of rights is an important element in maintaining family stability and happiness].
Nicolas Van Oost. Entre l'académie et la pratique professionnelle
Authors: Scialpi Giulia , Van Oost Nicolas
Published: April 2023

Résumé. Nicolas Van Oost est architecte et ingénieur. En 1987, il démarre sa carrière au bureau d'Émile Verhaegen. Depuis 2016, il est chairman chez Archipelago. Un bureau d'étude qui s'engage dans des projets institutionnels et d'utilité publique dans les domaines de la santé, de l'éducation et de la recherche. En 1994, il commence sa mission à l'UCLouvain en tant que maître deconférences invité. Depuis 2015, il est professeur à LOCI et responsable de l'Atelier Institution et édifice et des cours Matières à construire, Gestion de projet et monde de l'édification. Il collabore aussi à l'atelier de projet d'architecture Synthèse. Depuis plus de six ans, il représente également l'UCLouvain à l'Ordre des architectes. Il est père de trois enfants, collectionneur d'art moderne et contemporain et il est passionné par l'aquarelle.

Abstract. Nicolas Van Oost is an architect and engineer. He began his career at Emile Verhaegen's office in 1987. He has been chairman of archipelago since 2016. A design office that engages in institutional projects and projects of public utility in the fields of health, education, and research. He first joined UCLouvain as a guest lecturer in 1994. Since 2015, he has been a professor at LOCI, where he leads the Institution and Building workshop and the courses Materials to Build and Project management and the world of construction. He is also active in the Synthesis workshop. For over six years, he has been UCLouvain's representative to the Ordre des architectes (Order of Architects). The father of three children, he collects modern and contemporary art and is passionate about watercolor.
Multicriteria Methodology for Selection of a Personal Electric Vehicle
Authors: Gomes Carlos Francisco Simões , Sousa Francisco , Pereira Teresa , Oliveira Marisa , Torres Luís Norberto Miranda
Published: April 2023

A methodology that can support the decision process for selecting an Electric Vehicle (EV) is crucial. Considering the quantity, diversity, and complexity of existing EV models, their advantages and disadvantages, and people's increasing concern for sustainability, selecting and buying a personal EV appropriate to one's needs and requirements is not a simple task. Currently, criteria such as price, consumption per 100 km, range, comfort, brand, safety, and technology can be used to analyse available EV models. In this context, the decision-making process can be supported by the Multicriteria Decision Analysis (MCDA), “a method that clearly structures and evaluates complex problems with several alternatives, conflicting criteria, and complex scenarios. The novelty of this paper is to present a hybrid MCDA approach, combining two powerful methods (AHP and PROMETHEE) into a single framework to assist EV selection by any given person who has no multicriteria knowledge. A survey was conducted to define relevant criteria for a private person selecting an EV. The approach was validated for EV selection, considering the available offer within a target value, based solely on available public data, and excluding qualitative criteria. The paper discusses a case study whereby the proposed approach, using both quantitative and qualitative criteria, assists a decision-maker in selecting an EV from a set of alternatives, validated by the decision-maker, proving the importance and relevance of supporting the decision-making process.
Efficiency of repeated corrective surgery in patients with spinal deformities: analysis of the immediate results of a monocenter cohort and a brief review of the literature
Authors: Mikhaylovskiy M. V. , Sorokin A. N. , Sergunin A. Yu. , Gubina E. V.
Published: April 2023

Objective. To analyze the results of repeated corrective surgery in patients with spinal deformities of various etiologies.

Material and Methods. The study group included 87 patients (mean age is 22.8 years, m : f = 10 : 77) who underwent repeated deformity correction using third-generation instrumentation (CDI and its analogues), and were selected from 144 patients previously operated on for spinal deformities of various etiologies using different types of spinal instrumentation. The magnitude of scoliotic deformity, thoracic kyphosis, lumbar lordosis, rotation of the apical vertebra, the volume of intraoperative blood loss, and the duration of the operation were assessed. All patients answered the questions of the SRS-24 questionnaire at the stages of treatment and postoperative follow-up, and were also examined by computer optical topography method.

Results. Out of 87 reoperated patients, 74 had idiopathic scoliosis. In 31 patients, the results were evaluated within a period of at least 2 years (average 61.8 months). As a result of the intervention, the primary curve was corrected by 29.1° (36.5 %). Loss of correction was 4.6° (p < 0.001), derotation of the apical vertebra – from 34.9° to 22.1° (p < 0.001) and loss of correction – 0.8°. The average blood loss varied from 810 to 1138 ml, and the operation time – from 187 to 289 min. Computer optical topography data convincingly confirmed the corrective effect achieved during the repeated intervention. According to the questionnaire (SRS-24), satisfaction with the results of the operation was quite high.

Conclusion. Repeated corrective interventions in patients with spinal deformities of various etiologies, even in long-term periods, can partially restore the lost primary correction and improve the quality of life of patients, which is confirmed by clinical and radiographic data, the results of computer optical topography and the SRS-24 questionnaire.