bluuebunny/crossref_metadata_2025 huggingface dataset:
A pilot tagging program on southern rays bream (Brama australis): methodology and preliminary recaptures
Authors: Wiff Rodrigo , Flores Andrés , Gacitúa Santiago , Donovan Carl R. , Canales T. Mariella , Ahumada Mauricio , Queirolo Dante
Published: March 2023

The southern rays bream (Brama australis) is a highly migratory, epi-mesopelagic species supporting an important artisanal fishery off central-southern Chile. Despite its importance, several questions exist about this species's demography and migratory routes. The first step in understanding the migratory behavior of B. australis is to test the feasibility of a conventional tagging program, a standard mark-recapture method, to infer migration in fish. Between February 2020 and December 2021, conventional tagging was conducted during 21 fishing trips on board artisanal vessels off Lebu harbor (Biobío Region, Chile) using gillnets, longlines, and handlines. Three thousand nine hundred forty-six individuals of B. australis between 30 and 55 cm fork length were tagged using external T-anchor bar labels (commonly known as "spaghetti"). Approximately 100 and 200 fish were tagged per fishing trip using longlines and gillnets, respectively. The size distribution of the tagged individuals was consistent with those retained in the catch, with 90% of tagged fish being longer than the fork length at 50% maturity. Eight tags have been recovered off the coast of Lebu up to May 2022. With times at liberty between 50 and 537 days. These preliminary recaptures are also analyzed in the context of the conceptual model for demography and migration proposed for this species in Chile. The main conclusion of this research is that a conventional tagging program is feasible for B. australis in Chile.
Individual and synergistic effect of highly diluted bioactive compounds and probiotic actinomycetes on the growth and survival of juvenile shrimp Penaeus vannamei
Authors: Mazón-Suástegui José Manuel , García-Bernal Milagro , Medina-Marrero Ricardo , Arcos-Ortega Guadalupe Fabiola , Campa-Córdova Ángel Isidro , López-Carvallo Jesús Antonio
Published: March 2023

The objective of this study was to evaluate two Streptomyces spp. probiotic strains (RL8 and N7) and four highly-diluted bioactive compounds (HDBC) in the growth, survival, and modulation of the microbial content in culture water and hepatopancreas of juvenile white shrimp Penaeus vannamei. An experimental design was applied with five treatments in triplicate, including T1: (RL8+N7); T2: [(ViP-7C+ViA-7C) + (PhA-7C+SiT-7C)]; T3: [(ViP-7C+ViA-7C) + (PhA-7C+SiT-7C) + (N7)]; T4: [(ViP-7C+ViA-7C) + (PhA-7C+SiT-7C) + (RL8)] and T5 as the control without actinobacteria or HDBC. T2 showed significant differences (P < 0.5) in height increase compared to the other treated and control groups. The organisms in T2, T3, and T4 recorded higher weight gain compared to T1 and T5. A survival rate from 94.13 ± 2.12 to 99.01 ± 2.45% was obtained with a significant difference (P < 0.05) between T1, T2, and T3, concerning the untreated control (T5). A significant decrease in Vibrio spp. the content was observed in water and shrimp in T1 and T2 concerning the control. The heterotrophic bacterial count in hepatopancreas increased with all treatments compared to T5. Our results suggest a positive synergy between the HDBC mixture [(ViP-7C+ViA-7C) + (PhA-7C+SiT-7C)] and N7 Streptomyces sp. strain, whose probiotic action has been previously demonstrated by improving culture conditions for P. vannamei juveniles in terms of growth, survival, and reduction of potentially pathogenic bacteria.
Pseudoxanthoma Elasticum: A Case Report
Authors: Vargu Migena , Vargu Petrit , Dedej Sabina , Kurushi Eriselda , Tandili Alketa , Ceca Stela , Çafka Majlinda , Zekja Ilirjana , Vasili Ermira
Published: March 2023

BACKGROUND: Pseudoxanthoma elasticum (PXE) is a rare, genetic, metabolic disease with autosomal recessive inheritance caused by mutations in the ABCC6 gene. The lack of functional ABCC6 protein leads to ectopic mineralization that is most apparent in the elastic tissues of the skin, eyes, and blood vessels. Dermatologic manifestations consist of small yellow papules on the nape and sides of the neck and in flexural areas that coalesce into reticulated plaques resembling the cobblestone aspect, and then the skin becomes loose and wrinkled. Histopathologic findings provide characteristic clues such as short, fragmented, clumped, and calcified mid-dermal elastic fibers.
CASE PRESENTATION: A 27-year-old Albanian female was referred to the dermatology clinic with skin complaints for approximately 17 years. On physical examination, we observed “cobblestone pattern” lesion located in the anterior, lateral, and posterior aspects of the neck, bilateral axillary, inguinal, antecubital, and popliteal regions, and periumbilical area. A biopsy was performed and the histopathology confirmed the typical changes in the dermis because of ectopic mineralization. The funduscopy revealed the “peau d’orange” aspect, bilateral angioid streaks but no neovascularization. Carotid echography showed minimal intimate thickening with flow acceleration but without significant stenosis of the right common carotid artery (ACC). Different laboratory exams were conducted that resulted within the normal range.
CONCLUSION: There is no specific treatment, and therapeutical management is based on prevention, tracking, and follow-ups to increase surveillance of clinical complications through a multidisciplinary team. The dermatologist is usually the first who faces Pseudoxanthoma elasticum manifestations. Therefore, the dermatologist should provide the patient with the best therapeutical and preventive approaches.
Effect of Analgesic Opioid Drugs on Opioid Receptor Genes Expression in HL-1 Mouse Cardiac Myocytes
Authors: Al Abdulmonem Waleed
Published: March 2023

BACKGROUND: The opioid system was mainly involved three types of opioid receptors (ORs): μ (MOR), δ (DOR) and κ (KOR). These ORs are activated by its agonist, a family of endogenous peptides: Endorphins, enkephalins, and dynorphins, respectively.
AIM: This study determined the OR mRNA on effects of agonists exogenous morphine, fentanyl, D-penicillamine (2,5) enkephalin, and ketazocine in HL-1 mouse cardiac myocytes.
MATERIALS AND METHODS: HL-1 mouse cardiac myocytes were treated with 10 μM morphine sulfate, 1 μM fentanyl,1 μM D-penicillamine (2,5) enkephalin, and 1 μM ketazocine. Total mRNAs were extracted and cDNA was synthesized and quantitative real-time polymerase chain reaction was used to analyze gene expression.
RESULTS: The data analysis of MOR, DOR and KOR mRNA expression on effect of morphine was shown less level than control (0.61-fold, 0.67-fold, and 0.65-fold), respectively. The morphine-induced ORs down-regulation, whereas enkephalin treatment demonstrated highly significantly increased in mRNA of DOR (6.3-fold, p = 0.002). As well as, KOR mRNA expression was found highly significant increased under effect of Ketazocine (7.16-fold, p = 0.004).
CONCLUSION: This study found DOR and KOR, but not MOR expressed in HL-1 mouse cardiac myocytes under activation of exogenous opioid analogists. These findings suggested that exogenous analogist’s opioids mimeses the endogenous analogist’s opioids.
A Neuro Symbolic Approach for Contradiction Detection in Persian Text
Authors: Rahimi Zeinab , Shamsfard Mehrnoush
Published: March 2023

Detection of semantic contradictory sentences is a challenging and fundamental issue for some NLP applications, such as textual entailments recognition. In this study, contradiction means different types of semantic confrontation, such as negation, antonymy, and numerical. Due to the lack of sufficient data to apply precise machine learning and, specifically, deep learning methods to Persian and other low-resource languages, rule-based approaches are of great interest. Also, recently, the emergence of new methods such as transfer learning has opened up the possibility of deep learning for low-resource languages. This paper introduces a hybrid contradiction detection approach for detecting seven categories of contradictions in Persian texts: Antonymy, negation, numerical, factive, structural, lexical and world knowledge. The proposed method consists of 1) a novel data mining method and 2) a transformer-based deep neural method for contradiction detection . Also, a simple baseline is presented for comparison. The data mining method uses frequent rule mining to extract appropriate contradiction detection rules employing a development set. Extracted rules are tested for different categories of contradictory sentences. In the first step, a classifier checks whether the rules work for an input sentence pair. Then, according to the result, rules are used for three categories of negation, numerical, and antonym. In this part, the highest F-measure is obtained for detecting the negation category (90%), the average F-measure for these three categories is 86%, and for the other four categories, in which the rules have a lower F-measure of 62%, the transformer-based method achieved 76%. The proposed hybrid approach has an overall f-measure of higher than 80%. 
The Alien to Cyprus Entomofauna (ACE) database: a review of the current status of alien insects (Arthropoda, Insecta) including an updated species checklist, discussion on impacts and recommendations for informing management
Authors: Demetriou Jakovos , Radea Canella , Peyton Jodey M. , Groom Quentin , Roques Alain , Rabitsch Wolfgang , Seraphides Nicos , Arianoutsou Margarita , Roy Helen E. , Martinou Angeliki F.
Published: March 2023

Alien insects represent one of the most species rich groups of organisms introduced to Europe, with some responsible for adverse social-economic, human-health, biodiversity and ecosystem impacts. The impacts of invasive alien species, especially on island ecosystems, have been a hot topic of research worldwide. Cyprus is a Mediterranean island at the biogeographic crossroads of Asia, Africa and Europe. This study presents the database of the alien insects of the island of Cyprus as a whole, created through an extensive review including grey literature and online sources. The Alien to Cyprus Entomofauna (ACE) triples the known number of alien insects and adds supplemental information to existing species. Data concerning a total of 349 alien insects are presented alongside an updated checklist and recommendations for informing management. The status of alien insects on the island, their origin, trophic guilds, establishment, pathways of introduction and impacts are discussed. Developing an alien species inventory for the island is challenging due to its geographic position and the increasing movement of people and goods leading to new species introductions. This publication constitutes an important first step towards providing information for effective actions to tackle invasive alien insects on Cyprus. The checklist and accompanying information can underpin understanding of the status and trends of alien species including providing information for risk assessments. ACE will continue to be maintained and updated as new records for Cyprus are made.
Histology and fine structure of epidermal papillomas in the Alpine newt Ichthyosaura alpestris (Urodela: Salamandridae)
Authors: Greven Hartmut , Guex Gaston-Denis
Published: March 2023

Epidermal papillomas of alpine newts (Ichthyosaura alpestris) collected in the field (Germany, Austria) were studied by histology (LM), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Papillomas were found on the head, the trunk and the tail, with the most and largest on the head of males. They protruded beyond the body surface exhibiting an appearance like a cauliflower. The head of one specimen studied by SEM had a large papilloma and was densely populated with bacteria, fungi and sessile ciliates. The surface of papillomas was covered either by stratum corneum cells, or by deeper cell layers that may be exposed by injuries. Histology revealed that papillomas consisted of compact bulbous extensions that were deeply embedded into the dermis and separated from each other by small septa (papillae) of connective tissue. Bulbs were distinctly demarcated by a thin basal lamella that was continuous with the basal lamella of the adjacent non-altered epidermis. An invasion of papilloma-cells through the basal lamella in the underlying connective tissue could not be unequivocally demonstrated; only once we found an area by TEM, which could be interpreted in this way. Bulbs may have two types of cavities or cysts. One type contained masses of keratinized cell layers, the other appeared either largely empty, or contained cellular debris and/or PAS-positive substances discharged by secretory cells lining the cyst. Tumor cells within a bulb are offen arranged in clusters or nests. Generally, cells appeared relatively undifferentiated having large euchromatic or heterochromatic nuclei, prominent nucleoli, and a moderate amount of cell organelles. Also the amount of tonofilamets and number and size desmosomes (macuale adhaerentes) seemed to be reduced. Virus-like particles were found neither in the cytoplasm nor in the nucleus. Compared to the unaltered epidermis, in which no mitoses were seen, mitotic cells occurred in all papillomas examined. In addition, the neoplastic tissue always contained macrophages and further ‘leucocytes’, but necrotic areas were rare. Dermal papillae separating the bulbs from each other and the dermal tissue immediately beneath the basal lamina of papillomas contained a high number of cells (e.g., fibroblasts and cells of the immune system).
Variability in pulmonary reduction and asymmetry in a serpentiform lizard: The sheltopusik, Pseudopus apodus (Pallas, 1775)
Authors: Lambertz Markus , Arenz Nils , Grommes Kristina
Published: March 2023

Besides snakes, numerous lineages of squamates gave rise to limb-reduced and elongated (serpentiform) species, indicating the evolutionary success of this modification of the plesiomorphic lizard Bauplan. Concerted with a serpentiform habitus are several morphological adaptations, many of which also concern the structure and arrangement of the viscera, such as frequently a pronounced pulmonary asymmetry in which one lung is reduced or even absent. The European glass lizard or sheltopusik, Pseudopus apodus, is the largest species of the exclusively serpentiform Anguinae. Driven by pre-existing conflicting statements on pulmonary asymmetry, we examined the lungs of 14 sheltopusiks and compared the condition to 11 slow worms (Anguis fragilis). We consistently found the left lung pronouncedly shorter for the slow worm, but indeed a highly variable pulmonary asymmetry between left and right sides in the sheltopusik. This is the first verified case of such variability in pulmonary reduction for any serpentiform squamate and raises several questions about the underlying developmental program for this otherwise taxon-specifically conservative trait.
Under an assumed name: the identity of Nanobagrus fuscus (Popta, 1904) clarified (Actinopterygii: Siluriformes)
Authors: Ng Heok Hee
Published: March 2023

Nanobagrus fuscus is redescribed on the basis of fresh material collected from the Mentaya River drainage, Borneo. The identity of material from central Sumatra, the Malay Peninsula and western Borneo previously identified as this species is reidentified here as N. torquatus.
Atividades humanas, comunicação e as faces do consumo
Authors: Dugnani Patricio
Published: March 2023

Nesse artigo pretende-se analisar o desenvolvimento do consumo partindo do debate das atividades humanas de Hannah Arendt, da antropologia do consumo de Grant McCracken e das etapas do consumo de Gilles Lipovetsky, para compreender como essa atividade, desde a organização das grandes civilizações até a atualidade, vem se tornando uma ação que norteia o pensamento da sociedade pós-moderna. Desse percurso deverá ser destacado o consumo do humano em seu período essencialmente nômade, passando pelo início da Idade Moderna, e as transformações após a Revolução Industrial. Será observado, também, como as transformações nos meios de comunicação interferem com a dinâmica do consumo, de acordo com Marshall McLuhan e Henry Jenkinsins.
Estádios, multidões e rituais de intensidade em H. U. Gumbrecht
Authors: Montargil Gilmar , Lopes da Silveira Fabrício
Published: March 2023

Centrando-se quase integralmente na leitura do livro Crowds. The Stadium as a Ritual of Intensity, de Hans Ulrich Gumbrecht (2021), o texto revisita aspectos da obra do autor, examinando-a num arco de desenvolvimentos, recorrências, impasses e enfatizações. Por um lado, reencontra categorias tradicionais relativas à perspectiva das materialidades da comunicação; por outro, descobre atualizações importantes, que a enraízam no presente conturbado em que vivemos e renovam suas conexões com os estudos de mídia e com a sociologia das comunicações de massaa.
Market Access Enablers for Small-Scale Crop Farmers
Authors: Maiwashe-Tagwi Aluwani
Published: March 2023

Cooperatives are deemed as vehicles for rural development, especially in developing countries. Smallholder farmers generally experience huge marketing transactional costs, and to reduce this they normally resort to becoming members of cooperatives. In South Africa, most small-scale farmers do not have access to markets. With no markets in place, the transformation would be almost impossible. The study's aim was to assess the determinants of market access in agricultural cooperatives in Limpopo Province. A face-to-face survey was conducted with 146 agricultural cooperatives members. The results showed that market access was associated with age, training, workers in a household, knowledge of the cooperatives principles and act, annual income, and access to funding. The study recommended younger farmers be targeted when designing market access interventions as the impact of job creation is huge amongst this group. Tailor-made training on market access and cooperative principles and acts should be designed. Funding should be made more accessible to small-scale farmers in cooperatives.
Green Innovation in Tourism Businesses
Authors: Tekeli Mehmet
Published: March 2023

Today, while all countries worldwide emphasize the significance of environmental awareness, among the sector areas, the tourism sector is the one that should focus on this matter most. The current study aimed, with examples from the tourism industry, to reveal the perspective of tourism businesses on green innovation practices, their practices, and the results obtained. After giving information about the innovation concept, scope, and types in general, this study provided fundamental explanations about the green innovation concept, scope, and types and dealt with the concept of green innovation in tourism businesses. Finally, the current study that provided general information about tourism environmental awareness certificates assessed the tourism sector by presenting examples of green innovation applications.
Technological Innovations in Tourism Businesses
Authors: Singh Pramendra , Sharma Disha
Published: March 2023

Technological innovations are bringing major breakthroughs and radical changes in the way businesses function. These technological innovations are helping all the industries to smooth their functions and provide better experiences to the customers. The tourism industry is also witnessing tremendous improvements in technological innovations. The chapter aims to study the different types of technologies that have emerged in recent times in tourism businesses. This study is conceptual in nature and uses various secondary sources for data collection along with the study of various cases to comprehend the usage of technology. The study concludes in supporting the statement made by world's largest and nodal tourism organization, United Nations World Tourism Organization, that technology and digitization are emerging, disrupting, and affecting our lives in such a way that augurs the begging of the next generation industrial revolution.
Central Bank Digital Currency, Poverty Reduction and the United Nations Sustainable Development Goals
Authors: Ozili Peterson K.
Published: March 2023

This chapter examines the role of central bank digital currency for poverty reduction and sustainable development. In the chapter, the author argues that a CBDC can eliminate poverty by first increasing financial inclusion which then gives poor people access to affordable credit and other basic financial services which they can use to improve their welfare, thereby enabling them to rise above poverty. This argument is valid only if a central bank digital currency is specially designed to incorporate features that increase financial inclusion for poor banked and unbanked adults. The argument may not apply to cases where a CBDC is not designed to increase financial inclusion as is the case in developed countries.
Enhancing Brain Imaging Using Super Resolution
Authors: Bhadauria Madhulika , Khurana Rishita , Aramvith Supavadee
Published: March 2023

Super-resolution reconstruction creates one or more high-resolution images from a collection of low-resolution frames. This chapter examines a number of super-resolution methods proposed over the last two decades and provides an overview of the contributions made recently to the broad super-resolution problem. During the procedure, a thorough examination of numerous crucial elements of super-resolution is presented, which are frequently overlooked in the literature. The authors have also outlined various advancements and studies that have been done in the particular domain. The prime focus of this chapter is to highlight the importance and application of super resolution in brain MRI and explore all the work that has been done in the field so far. The experiments on simulated and actual data are used to support novel strategies for tackling the difficulties faced while implementing the technique. Finally, several prospective super-resolution difficulties are identified, and methodologies are presented.
Data Analysis Tools for Neural Data Cognitive Computing
Authors: Srivastava Shiddarth , Sharma Rashmi
Published: March 2023

The ability to draw conclusions and take action from data hasn't altered all that much despite significant technological developments in recent years. Applications are still typically created to carry out predefined tasks or automate business procedures; therefore, the logic must be coded to account for all possible usage scenarios. They do not grow from their mistakes or adjust to changes in the data. Although they are cheaper and faster, computers aren't substantially smarter. Of course, people now aren't all that much brighter than they were in the past. For both humans and machines, that is about to change. The old notion of computing as process automation is being replaced by a new generation of information systems that offer a collaborative platform for discovery. These systems' initial wave has already improved human cognition in a number of areas.
Mast Cell Proteases Cleave Prion Proteins and a Recombinant Ig against PrP Can Activate Human Mast Cells
Authors: Willows Steven D , Semenchenko Valentyna , Norman Grant , Woodside Michael T , Sim Valerie L , Kulka Marianna
Published: March 2023

IgE Abs, best known for their role in allergic reactions, have only rarely been used in immunotherapies. Nevertheless, they offer a potential alternative to the more commonly used IgGs. The affinity of IgE Ag binding influences the type of response from mast cells, so any immunotherapies using IgEs must balance Ag affinity with desired therapeutic effect. One potential way to harness differential binding affinities of IgE is in protein aggregation diseases, where low-affinity binding of endogenous proteins is preferred, but enhanced binding of clusters of disease-associated aggregated proteins could target responses to the sites of disease. For this reason, we sought to create a low-affinity IgE against the prion protein (PrP), which exists in an endogenous monomeric state but can misfold into aggregated states during the development of prion disease. First, we determined that mast cell proteases tryptase and cathepsin G were capable of degrading PrP. Then we engineered a recombinant IgE Ab directed against PrP from the V region of a PrP-specific IgG and tested its activation of the human mast cell line LAD2. The αPrP IgE bound LAD2 through Fc receptors. Crosslinking receptor-bound αPrP IgE activated SYK and ERK phosphorylation, caused Fc receptor internalization, and resulted in degranulation. This work shows that a recombinant αPrP IgE can activate LAD2 cells to release enzymes that can degrade PrP, suggesting that IgE may be useful in targeting diseases that involve protein aggregation.
CD4 T Cell–Dependent and –Independent Roles for IFN-γ in Blood-Stage Malaria
Authors: Drewry Lisa L , Pewe Lecia L , Hancox Lisa S , Van de Wall Stephanie , Harty John T
Published: March 2023

Production of IFN-γ by CD4 T cells is widely theorized to control Plasmodium parasite burden during blood-stage malaria. Surprisingly, the specific and crucial mechanisms through which this highly pleiotropic cytokine acts to confer protection against malarial disease remain largely untested in vivo. Here we used a CD4 T cell–restricted Cre-Lox IFN-γ excision mouse model to test whether and how CD4 T cell–derived IFN-γ controls blood-stage malaria. Although complete absence of IFN-γ compromised control of the acute and the chronic, recrudescent blood-stage infections with P. c. chabaudi, we identified a specific, albeit modest, role for CD4 T cell–derived IFN-γ in limiting parasite burden only during the chronic stages of P. c. chabaudi malaria. CD4 T cell IFN-γ promoted IgG Ab class switching to the IgG2c isotype during P. c. chabaudi malaria in C57BL/6 mice. Unexpectedly, our data do not support gross defects in phagocytic activity in IFN-γ-deficient hosts infected with blood-stage malaria. Together, our data confirm CD4 T cell–dependent roles for IFN-γ but suggest CD4 T cell–independent roles for IFN-γ in immune responses to blood-stage malaria.
Clinicopathologic significance of the delta-like ligand 4, vascular endothelial growth factor, and hypoxia-inducible factor-2α in gallbladder cancer
Authors: Park Sujin , Kim Junsik , Jang Woncheol , Kim Kyoung-Mee , Jang Kee-Taek
Published: March 2023

Background: Gallbladder cancer (GBC) is usually detected in advanced stages with a low 5-year survival rate. Delta-like ligand 4 (DLL4), vascular endothelial growth factor (VEGF), and hypoxia-inducible factor-2alpha (HIF2α) have been studied for their role in tumorigenesis and potential for therapeutic target, and multiple clinical trials of the agents targeting them are ongoing. We investigated the expression of these markers in surgically resected GBC and tried to reveal their association with the clinicopathologic features, mutual correlation of their expression, and prognosis of the GBC patients by their expression. Methods: We constructed the tissue microarray blocks of 99 surgically resected GBC specimens and performed immunohistochemistry of DLL4, VEGF, and HIF2α. We used the quantitative digital image analysis to evaluate DLL4 and VEGF expression, while the expression of HIF2α was scored manually. Results: The expression of VEGF and HIF2α showed a significant trend with tumor differentiation (p= .028 and p= .006, respectively). We found that the high DLL4 and VEGF expression were significantly correlated with lymph node metastasis (p= .047, both). The expression of VEGF and HIF2α were significantly correlated (p < .001). The GBC patients with low HIF2α expression showed shorter recurrence-free survival than those with high HIF2α expression. Conclusions: This study suggested the possibility of the usage of DLL4 and VEGF to predict the lymph node metastasis and the possibility of VEGF and HIF2α to predict the expression level mutually. Further studies may be needed to validate our study results and eventually accelerate the introduction of the targeted therapy in GBC.
Combination of the LARS1 Inhibitor, BC-LI-0186 with a MEK1/2 Inhibitor Enhances the Anti-Tumor Effect in Non–Small Cell Lung Cancer
Authors: Lee Sang Hoon , Kim Eun Young , Han Jung Min , Han Gyoonhee , Chang Yoon Soo
Published: March 2023

Purpose The mammalian target of rapamycin complex 1 (mTORC1) regulates cell growth and proliferation by growth factor coordination and amino acid availability. Leucyl-tRNA synthetase 1 (LARS1) senses the intracellular leucine concentration and mediates amino acid-induced activation of mTORC1. Thus, LARS1 inhibition could be useful in cancer treatment. However, the fact that mTORC1 can be stimulated by various growth factors and amino acids suggests that LARS1 inhibition alone has limitations in inhibiting cell growth and proliferation. We investigated the combined effects of BC-LI-0186, a LARS1 inhibitor, and trametinib, an MEK inhibitor, on non–small cell lung cancer (NSCLC).Materials and Methods Protein expression and phosphorylation were observed by immunoblotting, and genes differentially expressed between BC-LI-0186–sensitive and –resistant cells were identified by RNA sequencing. The combined effect of the two drugs was inferred from the combination index values and a xenograft model.Results LARS1 expression was positively correlated with mTORC1 in NSCLC cell lines. BC-LI-0186 treatment of A549 and H460 cells maintained in media supplemented with fetal bovine serum revealed paradoxical phosphorylation of S6 and activation of mitogen- activated protein kinase (MAPK) signaling. Compared with BC-LI-0186–sensitive cells, –resistant cells showed enrichment of the MAPK gene set. The combination of trametinib and BC-LI-0186 inhibited the phosphorylation of S6, MEK, and extracellular signal-regulated kinase and their synergistic effects were confirmed in a mouse xenograft model.Conclusion The combination of BC-LI-0186 and trametinib inhibited the non-canonical mTORC1-activating function of LARS1. Our study demonstrated a new therapeutic approach for NSCLC without targetable driver mutations.
The colored Jones polynomial of the figure-eight knot and a quantum modularity
Authors: Murakami Hitoshi
Published: March 2023

We study the asymptotic behavior of the N-dimensional colored Jones polynomial of the figure-eight knot evaluated at
$\exp \bigl ((u+2p\pi \sqrt {-1})/N\bigr )$
, where u is a small real number and p is a positive integer. We show that it is asymptotically equivalent to the product of the p-dimensional colored Jones polynomial evaluated at
$\exp \bigl (4N\pi ^2/(u+2p\pi \sqrt {-1})\bigr )$
and a term that grows exponentially with growth rate determined by the Chern–Simons invariant. This indicates a quantum modularity of the colored Jones polynomial.
Reporting of Azithromycin Activity against Clinical Isolates of Extensively Drug-Resistant Salmonella enterica Serovar Typhi
Authors: Jabeen Kokab , Saleem Sidrah , Nizamuddin Summiya , Arshad Faiqa , Jahan Shah , Hasnain Faisal , Tariq Waleed , Tahir Muhammad Junaid , Yousaf Zohaib , Asghar Muhammad Sohaib
Published: March 2023

This study aimed to evaluate the minimum inhibitory concentration (MIC) of azithromycin (AZM) in clinical isolates of extensively drug-resistant (XDR) Salmonella Typhi (i.e., resistant to chloramphenicol, ampicillin, trimethoprim-sulfamethoxazole, fluoroquinolones, and third-generation cephalosporin) using the E-test versus the broth microdilution method (BMD). From January to June 2021, a retrospective cross-sectional study was carried out in Lahore, Pakistan. Antimicrobial susceptibility was performed initially by the Kirby-Bauer disk diffusion method for 150 XDR Salmonella enterica serovar Typhi isolates, and MICs of all the recommended antibiotics were determined by the VITEK 2 (BioMérieux) fully automated system using Clinical Laboratory Standard Institute (CLSI) 2021 guidelines. The E-test method was used to determine AZM MICs. These MICs were compared with the BMD, which is the method recommended by the CLSI but not adopted in routine laboratory reporting. Of 150 isolates, 10 (6.6%) were resistant by disk diffusion. Eight (5.3%) of these had high MICs against AZM by the E-test. Only three isolates (2%) were resistant by E-test, having an MIC of 32 μg/mL. All eight isolates had a high MIC by BMD with different MIC distributions, but only one was resistant, having an MIC of 32 μg/mL by BMD. The sensitivity, specificity, negative predictive value, positive predictive value, and diagnostic accuracy of the E-test method versus BMD were 98.65%,100%, 99.3%, 33.3%, and 98.6%, respectively. Similarly, the concordance rate was 98.6%, negative percent agreement was 100%, and positive percent agreement was 33%. The BMD is the most reliable approach for reporting AZM sensitivity in XDR S. Typhi compared with the E-test and disk diffusion methods. Potentially, AZM resistance in XDR S. Typhi is around the corner. Sensitivity patterns should be reported with MIC values, and if possible, higher values should be screened for the presence of any potential resistance genes. Antibiotic stewardship should be strictly implemented.
The Development and Evaluation of a Combined Infection–Rheumatology Assessment Service in Response to the Chikungunya Fever Epidemic
Authors: Krutikov Maria , Donovan Joseph , Lambourne Jonathan , Ciurtin Coziana , Brown Mike , Bailey Robin , Manson Jessica J.
Published: March 2023

The chikungunya virus is an arthritogenic alphavirus. Acute infection may be followed by persistent arthralgia, often causing significant functional impairment. The 2014–2015 chikungunya fever (CHIKF) epidemic resulted in a marked increase in cases presenting to rheumatology and tropical diseases services. A combined multidisciplinary rheumatology–tropical diseases service for assessment, management, and follow-up of patients with proven CHIKF and persistent (≥ 4 weeks) arthralgia was proposed and rapidly developed at The Hospital for Tropical Diseases in London. Rapid set up of a multidisciplinary clinic in response to the epidemic was achieved. Of a total of 54 patients, 21 (38.9%) patients with CHIKF developed persistent arthralgia and were reviewed by the multidisciplinary service. A combined assessment approach enabled comprehensive multidisciplinary assessment of CHIKF, assessment of joint pathology through ultrasound, and appropriate follow-up. A combined rheumatology–tropical diseases service was successfully used to identify and assess CHIKF-associated morbidity. Future outbreaks may be approached by establishing tailored multidisciplinary clinics.
Analysis of the Perception and Satisfaction of Instructors and Learners on the Operation of the Liberal Arts Curriculum
－Focusing on C University
Authors: Huh Hye Yeon , Kim Mi Jeong
Published: March 2023

The purpose of this study was to derive a plan to improve the quality of the liberal arts curriculum by comparing learners and instructors' perceptions and satisfaction levels with the current status of the liberal arts curriculum at C University in Korea. Questions on awareness and satisfaction with the curriculum were developed, and online surveys were conducted for all members. Data were analyzed through descriptive statistics and content analysis methods. The findings reveled the following points.First, the items that represented the instructors and learners’high awareness levels of the liberal arts curriculum were“operation based on the educational purpose and core competencies of liberal arts education”and “the liberal arts education completion system,” respectively.Second, the item denoting instructors' satisfaction with the liberal arts curriculum was “change according to the results of consulting diagnosis,”and the reason given is that they perceive the shift in and the need to manage the quality of liberal arts education. Learners were highly contented with the “cultured education completion system”regarding (when you say “as in” do you mean “regarding” or “the same for”?) awareness. This is owing to the fact that the area is organized such that various courses can be completed, and a student is able to choose and listen to the desired subject.Third, learners have a higher awareness of the university's liberal arts education completion system than instructors and are slightly more satisfied with certain aspects, such as the fact that “cultured education operates based on educational purposes and core competencies” and in regards to the “cultured education completion system operation.”Finally, based on the results, implications for improving the quality of the liberal arts curriculum and future studies are suggested.
A Needs Analysis of Digital Citizenship Education for University Students in the Era of Great Digital Transformation
Authors: Kim Jieun , Kim Kyoung A
Published: March 2023

The purpose of this study is to analyze the need for digital citizenship education for university students in the era of great digital transformation, to explore ways to teach digital citizenship as part of liberal arts education in universities, and to reflect digital citizenship learning in our development of such courses. To this end, an online survey was conducted involving 414 university students in the Seoul metropolitan area. SPSS 25.0 was used to analyze the survey results. To perform a needs analysis, a t-test, the Borich needs assessment model, and the Locus for Focus model analysis were used, and the results were analyzed comprehensively. The main findings of this study are as follows. First, the results of the exploratory factor analysis of the digital citizenship scale constructed in this study extracted a total of 9 components: ‘digital identity’, ‘use of digital technology’, ‘balanced use of digital technology’, ‘digital security’, ‘digital empathy’, ‘digital communication’, ‘digital literacy and critical thinking’, ‘digital rights and responsibilities’, and ‘social participation through digital technology’. Second, this study examined the experiences and perceptions of digital citizenship education of the survey participants, and the findings indicated that most university students received digital citizenship education from elementary school, and that the awareness of the need for such education was very high. Third, the results of the needs analysis of digital citizenship education showed that ‘balanced use of digital technology’, ‘digital security’, ‘digital rights and responsibilities’, and ‘digital literacy and critical thinking’ had the highest priority, and that ‘social engagement through digital technology’ had a secondary priority. Based on the above findings, this study proposes an educational plan to enhance the digital citizenship competency of university students in the era of great digital transformation.
A Systematic Review of Self-Regulated Writing Strategies Related Research Trends in Korea
Authors: Hwang Soonhee
Published: March 2023

Self-regulated learning has received much attention in the realm of education since the mid 1980s, and there has been a good deal of domestic as well as overseas research in this area. In this context, self-regulated writing strategies have been designed and were proved to be effective for education on the writing process. However, to date, there is no research analyzing previous related research into this area in Korea. This study aims to analyze the research trends of self-regulated writing with a focus on domestic research, and to suggest implications for future research. For this purpose, 110 domestic research papers (graduate theses and academic articles published since 2000) were collected. All 110 research papers have been reviewed and classified according to analytical criteria such as year of publication, research method, learners and research topics.Our findings show that firstly, related research on self-regulated writing has been growing since 2000. Also, there was more research conducted using the quantitative method compared to research that made use of other research methods. Second, as a result of analyzing the research papers by learner's school level, most of the studies were conducted on elementary school students, followed by high school students, and finally middle school students. Third, research topics based on thematic analysis included six categories. Namely, self-regulated learning/strategy intervention and its effect analysis, analysis of variables related to writing ability, the utilization of writing activities, a self-regulation writing strategy plan, an exploration of the self-regulated writing process, and the development of a self-regulated writing related inventory and test. Based on these findings, it is necessary for us to continue studying self-regulated writing using various research methods, as well as to examine the research considering diverse variables.
Long Term Use of Leflunomide as a Cause of Severe Diarrhea?
Authors: Günendi Zafer , Benli Esin , Göğüş Feride , Atalay Fatma
Published: March 2023

Leflunomide is a recently developed disease modifying antirheumatic drug that may cause acute diarrhea as an adverse effect. This adverse effect is usually mild and develops during the first few weeks of treatment. In this report, we present a case of rheumatoid arthritis patient with severe diarrhea treated with leflunomide for an extended period of time. (Turk J Rheumatol 2010; 25: 41-3)
De lo nuevo a lo otro en el pensamiento de Heidegger
Authors: Cuenca Espinoza Maribel Martina
Published: March 2023

El presente artículo parte de la necesidad de reflexionar sobre la experiencia de lo nuevo en la historia humana y encuentra en el pensar heideggeriano sobre el comienzo y sobre el otro comienzo, en particular, un camino reflexivo que permite sincerar dicha experiencia. A partir del análisis de la relación íntima entre el otro comienzo y el primer comienzo, se mostrará una especie de “identidad” entre el acabar y el comenzar, lo que nos confrontará con el concepto de la contradicción, desde la historia pensada por Heidegger. En función de la crítica y de la finalización de la metafísica, se pensará en el lugar de la contradicción en la historia del ser y se subrayará la tensión entre el pensar lógico y la mostración de este. Ello nos conducirá, finalmente, a destacar a la historia como un comenzar permanente, antes que como un proceso atravesado por la innovación y el progreso.
Heidegger y la Naturphilosophie
Authors: Hernández-Villaescusa Hirsch Henrik
Published: March 2023

Prácticamente toda la producción de Heidegger en relación con Schelling orbita en torno a las Investigaciones sobre la esencia de la libertad humana, y así lo hace también la literatura secundaria que se ocupa del tema. En este artículo queremos preguntarnos, sin embargo, por otros materiales menos conocidos, para preguntarnos hasta qué punto han ejercido también alguna influencia en el desarrollo del pensamiento de Heidegger. Podemos, efectivamente, ver, en la superación schellingiana del Idealismo de Fichte, un avance del Dasein de SZ y, en la posición sistemática que la obra de arte adquiere en su filosofía, una cierta prefiguración de la filosofía del arte del Heidegger posterior. Pero será la liberación con respecto a la metafísica idealista, que se opera en la Filosofía de la Naturaleza de Schelling, lo que se nos revelará como la aportación más notable del pensamiento de este al de Heidegger.
El abismo de la voluntad
Authors: Lome Hurtado Luis Ángel
Published: March 2023

El artículo estudia la tercera y última confrontación con el Tratado de la libertad de Schelling que Heidegger sostuvo en 1941. El objetivo consiste en explicar el contexto del problema del acabamiento de la metafísica del idealismo alemán, para analizar la posición que tiene Heidegger de las nociones de diferencia y voluntad forjadas por la filosofía tardía de Schelling; de esta manera, a partir del abismo de la voluntad se muestra la intersección entre la filosofía de la libertad de Schelling y la ontología del evento de Heidegger.
Del “destello de un nuevo comienzo” a la “metafísica de la subjetividad absoluta”
Authors: Zaborowski Holger
Published: March 2023

En el siguiente artículo se aborda la interpretación de Heidegger del tratado de la libertad de Schelling en las dos lecciones dedicadas a esta obra sostenidas en los años 1936 y 1941. En un primer momento me referiré al carácter autorreferencial de la aproximación heideggeriana a la obra de Schelling en 1936. En este curso Heidegger sitúa a Schelling más allá del idealismo alemán y encuentra en él los impulsos necesarios para un nuevo comienzo del pensar, en correspondencia con la tarea programática del propio Heidegger en los años 30. A continuación me enfocaré en el giro radical de la interpretación heideggeriana con relación a Schelling en el curso de 1941, cuando al igual que a Hegel lo considera un exponente más de la metafísica absoluta del idealismo alemán.
IMMEDIATE EFFECTS OF COVID-19 PANDEMIC SITUATION ON LIVELIHOOD OF WOMEN CULTIVATORS IN THE COASTAL AREAS OF WEST BENGAL AND ODISHA
Authors: Banerjee Dr. Nilay
Published: March 2023

India is known for its dependence on agriculture and allied sectors as the major pillar of its economy. Being one of the major emerging nation in the world’s economic and political power scenario the country has been expected to stand in good position in terms reduction of poverty and livelihood development of the people particularly of the rural area. The spread of Covid-19 virus has attributed to huge economic squander worldwide and India is no more any exception, rather the economy is such badly affected due to this situation that the GDP growth has brought down to only 23.9% over the same quarter last fiscal. Due to the current pandemic situation a large portion of global population is in a deadly juncture for its livelihood options due to sudden unemployment and related poverty along with. High risk of getting infected by this deadly virus and it’s after effects. Specifically, the poor rural community who are largely dependent on agriculture and labour work are the worst hit ones due to this present situation. In this perplexing time being the vulnerable section women are again the most affected ones. This paper aims to understand the current situation and its immediate effect on the women cultivators of coastal parts of West Bengal and Odisha; the study also aims to find major facts towards their attitude of alternation of livelihood strategies. The study has been done exclusively on primary data.
STUDY ON TRANSLATION OF STEAMED DISH BASED ON NORD’S DOCUMENTARY AND INSTRUMENTAL TRANSLATION THEORY
Authors: Hongyao He , Jianguo Tian
Published: March 2023

Shaanxi characteristic snacks play an important role in Chinese cuisine. How to translate Shaanxi characteristic snacks well is of great significance to the development of Shaanxi tourism and the propagation of Chinese traditional food culture. The translator selects the steamed dish in Shaanxi characteristic cuisine as the translation research object, combined with Christian Nord’s documentary and instrumental translation theory, discusses, and studies the English translation of the steamed dish products and product introduction of Shaanxi Shenchu Food Co., Ltd., and puts forward some relevant suggestions.