bluuebunny/crossref_metadata_2025 huggingface dataset:
SPP1 is expected to be a biomarker for predicting prognosis and immunotherapy efficacy in penile cancer patients
Authors: Zou Yuantao , Tan Xingliang , Yuan Gangjun , Tang Yi , Wang Yanjun , Yang Cong , Luo Sihao , Yao Kai
Published: August 2022

Secreted phosphoprotein 1 (SPP1) has been confirmed to be involved in various biological processes of many kinds of tumors. However, the effect of SPP1 in Squamous cell carcinoma of the penis (PSCC) remains unknown. This study identified SPP1 as the potential biomarker related to the occurrence, metastasis and immune microenvironment of PSCC. 8 paired penile cancer specimens(including penile cancer tissue, paracancerous tissue, and positive lymph node tissue) conducting the whole transcriptome sequencing were analyzed to identify differentially expressed genes. And differential analysis indicated that SPP1 was the most differently up-regulated gene in both penile cancer tissues and positive lymph node tissues. Subsequently, analysis of SPP1 in the TCGA and TIMER database showed SPP1 was significantly associated with B cells, CD8 + T cells, CD4 + T cells, macrophages, neutrophils and dendritic cells in various tumor types. Survival analysis based on immunohistochemical staining of 183 PSCC paraffin sections suggested the survival prognosis of low SPP1 group was significantly higher than that of the high SPP1 group.The PSCC microarray dataset(GSE57955) from the Gene Expression Omnibus (GEO) was included in our study and a series of bioinformatics analysis was performed to explore the downstream mechanisms of SPP1 gene regulation and immune infiltration. The GO and KEGG analysis suggested that SPP1 might activates TGF-β related pathways and was closely related to the DNA and chromosome functions in the nucleus. ssGSEA and CIBERSORT analysis suggested that SPP1 was closely related to various immune infiltration-related cells in penile cancer, including CD4 + T cells, helper T cells. GSVA analysis and GSEA analysis suggested that SPP1 is closely related to MAPK, mTOR, Wnt and immune checkpoint (PD-1 and PD-L1) related pathways. Our study show SPP1 gene might be an effective biomarker for predicting the prognosis and the efficacy of immunotherapy of PSCC patients.
Statistical modelling of precipitation data in Canadian Prairies with a dynamic mixture structure
Authors: Mazjini Maral , Bae Taehan
Published: August 2022

The present paper aims to model statistical structure of heavy-tailed precipitation data. In particular for agricultural purposes in Canadian Prairies, this is essential in many aspects such as assessing and managing risks resulting from the occurrence of unexpected precipitation events. Daily (or weekly) precipitation time series often contain many zeros (on dry days) and also exhibit important characteristics such as heavy-tailedness and volatility clustering. These features make it challenging to develop an effective model from both theoretical and practical viewpoints. In this paper, we propose a dynamic mixture model constructed based on a generalized Gaussian crack distribution with a GARCH specification to take into account the full range of precipitation measurements with a sufficient flexibility to fit both thin and heavy-tailed data, and stochastic volatility. The method of maximum likelihood estimation with the profile log-likelihood algorithm is illustrated with some simulation studies. The model fitting results on a historical data set from twelve stations in Canadian prairies show the applicability of the proposed model.
Quantitative measurement of finger usage in stroke hemiplegia using ring-shaped wearable devices
Authors: Yamamoto Naoya , Matsumoto Takato , Sudo Tamami , Miyashita Megumi , Kondo Toshiyuki
Published: August 2022

Background: Positive use of affected limbs in daily life is important to improve the affected upper limb function in post-stroke rehabilitation. Several studies have been conducted to quantitatively evaluate the amount of upper limb activity, but few have measured the finger usage. In this study, we measured the upper limb and finger usage simultaneously in hospitalized hemiplegic stroke patients with a ring-shaped wearable device and investigated the association with the finger usage and general clinical evaluation.Methods: Twenty stroke hemiplegic patients staying in an inpatient hospital participated in this study. All patients wore a ring-shaped wearable device on both hands for 9 hours on the day of the intervention and the finger usage was recorded. For the outcome assessments of the rehabilitation, Fugl-Meyer Assessment Upper Limb (FMA-UL), Simple Test for Evaluating Hand Function (STEF), Action Research Arm Test (ARAT), Motor Activity Log-14 (MAL), and Functional Independence Measure Motor (FIM-m) were employed and were evaluated on the same day as the intervention. Results: The finger usage of affected hand was moderately correlated with STEF (r=0.48, p<.05) and STEF ratio (r=0.47, p<.05). The finger usage ratio was moderately correlated with FMA-UL (r=0.56, p<.05) and ARAT (r=0.53, p<.05), and strongly correlated with STEF (r=0.80, p<.01) and STEF ratio (r=0.80, p<.01). The upper limb usage of affected side was moderately correlated with FMA-UL (r=0.46, p<.05), STEF (r=0.55, p<.05) and STEF ratio (r=0.54, p<.05), and strongly correlated with ARAT (r=0.57, p<.01). The upper limb usage ratio was moderately correlated with ARAT (r=0.48, p<.05) and STEF (r=0.55, p<.05), and strongly correlated with STEF ratio (r=0.61, p<.01). By contrast, MAL has revealed no correlation with any of the measurements. Conclusions: These results suggest that this measurement technique is able to provide useful information that are not biased toward the subjectivity of patients and therapists.
Valuation Methods in Ecosystem Services: A Meta-analysis
Authors: Legesse Fekadu , Degefa Sileshi , Soromessa Teshome
Published: August 2022

Ecosystem services are the benefits people obtain from ecosystems, including provisioning, regulating, supporting, and cultural services. The Meta-analysis of this seminar was reviewed to identify, describe, and choose an appropriate ecosystem valuation method. Four major and nine sub-ecosystem services valuation methods were reviewed from scientific literature sources. Direct market-valuation methods are used to estimate ecosystem services via the use of direct market prices and production functions, indirect market valuation methods are used to estimate when direct markets for many ecosystem goods and services do not exist, direct market prices are missing, and stated preference valuation methods are used when no market prices are available, indirect market valuation methods are not possible, and the change in ecosystem services is hypothetical. The indirect market valuation methods can be used to estimate economic values for all types of ecosystem services. Ecosystem service modeling is used in integrating all the spatial and temporal dynamics of ecosystem services. The strength and limitations of each ecosystem services valuations method are summarized to know and choose appropriate valuation methods. The analysis shows different valuation methods exist and have been applied to estimate the values of different ecosystem services, but their appropriateness under specific conditions or limitations is not uniform. Thus, further study on the pros and cons of valuation methods will be needed to choose appropriate ecosystem valuation methods.
Impulse-controllability of system classes of switched differential algebraic equations
Authors: Wijnbergen Paul , Trenn Stephan
Published: August 2022

In this paper impulse controllability of system classes containing switched DAEs is studied. We introduce several notions of impulse-controllability of system classes and provide a characterization of strong impulse-controllability of system classes generated by arbitrary switching signals. In the case of a system class generated by switching signals with a fixed mode sequence it is shown that either all or almost all systems are impulse-controllable, or that all or almost all systems are impulse-uncontrollable. Sufficient conditions for all systems to be impulse-controllable or impulse-uncontrollable are presented. Furthermore, it is observed that although all systems are impulse-controllable, the input achieving impulse-free solutions might still depend on the switching times in the future, which causes some causality issues. Therefore, the concept of (quasi-) causal impulse-controllability is introduced and system classes which are (quasi-) causal are characterized. Finally necessary and sufficient conditions for a system class to be causal given some dwell-time are stated.
Association Between Weight Loss and Mortality in Idiopathic Pulmonary Fibrosis
Authors: Kalininskiy Aleksandr , Rackow Ashley Rose , Nagel David J , Croft Daniel , McGrane-Minton Heather , Kottmann R.Matthew
Published: August 2022

Rationale: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease that has no cure. Many current research efforts center on diagnostic and therapeutic modalities for IPF while other risk factors affecting disease pathogenesis receive less attention. Emerging data support the clinical importance of weight loss in patients with IPF. However, factors associated with weight loss and the impact of weight loss on mortality remain incompletely explored. Objectives: Explore the association between weight loss and transplant-free survival in patients with IPF and identify clinical variables associated with weight loss in this population. Methods: Kaplan-Meier and Cox proportional hazard regression analyses were generated and stratified by weight loss or use of antifibrotic medications. Conditional logistic regression was used to evaluate for factors associated with weight loss. Results: There was a significant increase in mortality in patients who lost ≥ 5% of their body weight loss (HR 2.21, [1.29, 4.43] p=.021). The use of supplemental oxygen (adjusted OR 13.16), and ≥200 mL loss of FVC over one year (adjusted OR 5.44) were both associated with a ≥5% weight loss in the year following a diagnosis of IPF. The use of antifibrotic medication did not significantly change median transplant-free survival in patients who lost more than ≥5% of their body mass. Conclusions: Weight loss over the first year following a diagnosis of IPF is strongly associated with decreased transplant-free survival. More research is needed to determine the mechanisms surrounding weight loss in patients with IPF.
Pirenperone relieves the symptoms of fragile X syndrome in Fmr1 knockout mice
Authors: Kim Yujeong , Jeon Se Jin , Gonzales Edson Luck , Shin Dongpil , Remonde Chilly Gay , Ahn TaeJin , Shin Chan Young
Published: August 2022

Fragile X syndrome (FXS) is one of the neurodevelopmental disorders that is caused by loss of FMRP. Many challenges have not succeeded to develop the proper therapeutics. FMRP is an RNA binding protein which can bind and recognize different RNA structures and regulate the target mRNAs’ translation involved in neuronal synaptic plasticity. Perturbations of this gene expression network have been related to abnormal behavioral symptoms such as hyperactivity, and impulsivity. Considering the physiological roles of FMRP in the modulation of mRNA translation, we focused to find the differentially expressed genes signature which might be targeted to revert into normal gene expression and amelioration of behavioral symptoms. We analyzed gene expression data and used the connectivity map (CMap) to understand the changes in gene expression signature in FXS and predict the effective drug candidates for FXS. We analyzed the GSE7329 dataset that had 15 control and 8 FXS patients’ lymphoblastoid samples. Among 924 genes, 42 genes were selected as signatures for CMap analysis and 24 drugs were found to be associated with gene expression changes. Pirenperone, a 5-HT 2A antagonist, was selected and validated as a potential drug candidate for FXS because of its possible antipsychotic effect. Treatment of pirenperone in cultured primary cortical neuron increased the expression level of Fmr1 gene. Moreover, we confirmed the rescue of behavioral phenotypes of FXS using Fmr1 knockout mice with pirenperone treatment. Overall, the results suggest that pirenperone is a new drug candidate for FXS, which should be verified in the future studies.
Ethanol extract of Lentinus edodes exerted antioxidant activity in Caenorhabditis elegans by regulating insulin DAF-16 signaling pathway
Authors: Li Quan-Cen , Li Na , Cai Wen-Wen , Liu Bin , Zeng Feng
Published: August 2022

Lentinus edodes (L. edodes) was a fungus plant, which was widely grown and eaten as food in China. As an antioxidant, the polysaccharide of L. edodes has been widely studied in terms of antioxidant activity, however, the effect of action and underlying mechanism of L. edodes ethanol extracts (LEEE) in antioxidant aspects were largely unknown. In this study, the antioxidant activity of LEEE was investigated in vitro. In addition, the antioxidant activity of LEEE was estimated in vivo through Caenorhabditis elegans model. It was found that LEEE had excellent antioxidant activity in vitro by scavenging DPPH, ABTS and hydroxyl radicals. At the same time, the anti-heat stress abilities of C. elegans were enhanced after supplementation with different concentrations of LEEE. The activities of antioxidant enzymes such as T-SOD, GSH-PX and CAT were significantly enhanced and the levels of MDA and ROS were significantly down-regulated. However, the level of apoptosis of C. elegans could not be improved after supplementation with LEEE. In the study of LEEE antioxidant-related signaling pathways through q-PCR experiments, it was found that LEEE exerted antioxidant activity in C. elegans by up-regulating MTL-1, DAF-16 and SOD-3 mRNA expression and down-regulating DAF-2 mRNA expression. This provided a solid foundation for the active substances of Lentinus edodes in improving oxidation-related diseases.
Dual-controlled tunable polarization-independent triple-band absorber using hybrid Dirac semimetal-vanadium dioxide metamaterial
Authors: Hu BaoJing , Hong SuMei , Ding HongWei , Huang Ming
Published: August 2022

In this paper, a dual-controlled tunable polarization-independent triple-band absorber using hybrid bulk Dirac semimetal (BDS) and vanadium dioxide (VO2) metamaterial is proposed. The physical properties of the absorber can be theoretically analyzed by the equivalent circuit model (ECM). When the Fermi energy of BDS increases from 0.11 eV to 0.15 eV, the peak frequencies also gradually increase and blue shift occurs. In addition, When the VO2 is in fully metallic state, the absorber exhibits three distinct absorption peaks with absorptances of 99.76%, 99.61% and 99.76%, respectively, with an average absorptance of 99.71%. As the the transition of VO2 from fully metallic state to insulating state, the transmittance and reflectance increase and the absorptance gradually decreases. Moreover, due to the structure symmetry of the absorber, the absorptance exhibits polarization independent behavior. Finally, the modulations of absorptivity spectra by tailoring the structure dimension and the potential for the application of the absorber as a refractive index sensor, are further discussed. This study provides potential applications in the design of multi-band dual–controlled tunable sensors, filters and absorbers.
Singular Spectral Analysis (Ssa) of Solid Earth Tide (Set) - Implications to Identify Earthquake Precursors and Earthquakes in the Himalayan Region (M≥6) During 1991-2021
Authors: M Senthil Kumar , Natarajan Venkatanathan
Published: August 2022

Several researchers are trying to formulate the earthquake-forecasting model using various earthquake precursors. There are numerous precursory phenomena have been identified in recent years. As many scientists suggested, the Solid Earth Tide (SET) can be considered as a reliable precursor since probably involved in the triggering mechanism of devastating earthquakes. In this paper, the authors choose notable earthquakes that occurred in the Himalayan region during 1991–2021. Due to the non-linear behaviour of the physical mechanism involved in the occurrence of earthquakes, we use Singular Spectral Analysis (SSA) to identify the irregularities in SET. SSA is a time series evaluation approach that incorporates the components of traditional-based time-series investigations, multidimensional statistical processes, complex systems, and data processing. From Eigenvalue function analysis (EOF), a strong correlation has been found between the magnitude of the earthquake and the percentage of the 6th component EOF. The aperiodicity in EOF was also found to be in three distinct patterns named Moose back eigenfunction (M-EOF), Camelback eigenfunction(C-EOF), and Triple Camelback eigenfunction (TC-EOF). One to four months prior to the occurrence of the earthquakes, a opposite phase shift was observed in the original series compared to the noise-free reconstructed series. Also, we have done the sliding window analysis, there is a notable coupling between SET and earthquake occurrence, when the tidal stress exceeds the critical level, the fault gets stimuli to slip. Thus, the authors concluded a strong possible reason for the irregularities in SET that can act as a triggering factor for earthquakes and other earthquake precursors.
Research on SpMV Implementation and vector x Hit Rate Optimization for SW26010p Many-Core Platform
Authors: Ma Mengfei , Wei Zhiqiang , Jing Xiaoli , Jia Dongning , Xu Jiali , Wang Yucheng , Zhang Chengfeng , Han Hengmin
Published: August 2022

In recent years, With the development of computer hardware, the supercomputer industry has ushered in a stage of rapid development, and its architecture has also evolved from traditional multi-core to many-core and heterogeneous many-core. Among them, sunway Many-Core Platform series with completely independent intellectual property rights is the representative of China’s supercomputing heterogeneous many-core processors. As a computing kernel, SpMV (sparse matrix-vector multiplication) is of great significance in scientific and engineering computing whose computing performance often has a great impact on the overall performance of applications. The article analyzes the master-slave acceleration architecture of the SW26010p Many-Core Platform processor and the implementation of the sparse matrix in the CSR storage format on the SW26010p Many-Core Platform. Due to the limited memory of the slave core of the SW26010p, the vector data stored in large-scale SpMV cannot be satisfied, resulting in a long memory access time and reduced performance. To solve this problem and optimize the calculation performance of SpMV, this paper has launched a research on the optimization strategy of SpMV for SW26010p Many-Core Platform. Firstly, we propose a method of assigning tasks by the number of rows in which the non-zero elements are located to solve the load balancing problem among slave cores. Secondly, we propose an adaptive memory allocation algorithm for LDM to achieve the optimal use of LDM memory. Thirdly, according to the refined division of the LDM space, various algorithms such as the dynamic and static double cache algorithm based on the secondary core architecture LRU and LUR-k, and the dynamic and static cache elimination algorithm based on the secondary core architecture ARC are proposed to improve the hit rate of vector x respectively. the performance of SpMV is optimized by reducing communication time and improving calculation and memory access ratio. Finally, several representative sparse matrices are selected from matrix set (Market) and tested, and the performance of several algorithms is analyzed. The results show that compared with the traditional method, the overall x hit ratio of our scheme is greatly improved, and the master-slave acceleration ratio is also greatly improved, the maximum acceleration ratio can reach more than 20 times and the average speed-up ratio can reach 10.5 times, which has a very good optimization effect. Meanwhile, the optimization methods adopted in this paper can be used for reference for other complex applications of SW26010p.
Prenatal alcohol consumption and risk of anemia among pregnant women attending antenatal care at public health facilities in Gondar town, Northwest Ethiopia: a retrospective cohort study
Authors: Addila Alemu Earsido , Azale Telake , Gete Yigzaw Kebede , Yitayal Mezgebu
Published: August 2022

Background: Alcohol consumption during pregnancy can lead to multiple health, social and, behavioral problems for both the mother and the offspring. Anemia is one of the major public health concerns and causes of morbidity and mortality among pregnant women with poor maternal and fetal outcomes in developing countries. This study aimed to identify the link between prenatal alcohol consumption and anemia among pregnant women attending antenatal care at public health facilities in Gondar town, Northwest Ethiopia.Methods: A facility-based retrospective cohort study was conducted among pregnant women who were booked for antenatal care in selected public health facilities from 29 October 2019 to 7 May 2020 in Gondar town. We used a two-stage random sampling technique to recruit and include study participants in the cohort. Data were collected using a standardized interviewer-administered questionnaire. Multivariable analysis was performed to examine the association between reported prenatal alcohol exposure (non-hazardous and hazardous) and anemia in pregnancy using log-binomial regression modeling. The burden of anemia in pregnancy was reported using the adjusted risk ratio and population-attributable risk (PAR).Results: A total of 1669(1113 unexposed and 556 exposed) pregnant women were included in the analysis. The prevalence of anemia during pregnancy was 14.86% (95% CI: 13.23, 16.65). Hazardous alcohol consumption during pregnancy was significantly associated with anemia in pregnancy (adjusted RR= 2.24; 95% CI: 1.60, 3.15), whereas there was no enough evidence for a statistical association between anemia and non-hazardous alcohol consumption during pregnancy (adjusted RR= 1.03; 95% CI: 0.79, 1.36). The adjusted PAR of anemia in pregnancy related to hazardous alcohol consumption during pregnancy was 7.68%.Conclusions: This study revealed that anemia during pregnancy continues to be a public health concern in Northwest Ethiopia. Regardless of timing, the clear association between prenatal hazardous alcohol consumption and increased risk of anemia during pregnancy suggests a need for targeted prenatal alcohol use and anemia screening, and ongoing intervention for alcoholic and anemic pregnant women.
LSTM based on Adaptive Convolutional Network for Time Series Classification
Authors: Li Yujuan , Wu Yonghong
Published: August 2022

Deep learning technology is the most effective method to solve time series classification tasks. The existing algorithms based on deep learning usually obtain features with fixed step convolution, so they cannot effectively extract and focus on important multi-scale features. Based on the complexity and long-term dependence of time series data, an end-to-end model called as Adaptive Convolutional Network Long-Short-Term Memory (ACN-LSTM) is proposed in this paper. This network is composed of two branches: long-short-term memory and adaptive convolution neural network. The LSTM uses memory cells and gate mechanism to control the transmission of sequence information and fully extract the correlation information of time series to enhance the discriminative power of the network. The ACN obtains the local characteristics of time series by stacking one-dimensional convolutional neural block. Then the multi-scale convolutional neural block is used to capture different scales of information, which is consist of concatenated convolutional layers with different kernel size. Meanwhile, in order to adaptively adjust the feature information between layers, an inter-layer adaptive channel feature adjustment mechanism is proposed. The ACN-LSTM not only fully extracts long-term time correlation information, but also fuses adaptively and pays attention to important multi-scale features to achieve more accurate classification results. The experiment results with 65 UCR standard datasets illustrate that the proposed ACN-LSTM achieves highest arithmetic mean rank and geometric mean rank, compared with other methods, which are 2.815 and 2.322, respectively, and also achieves the lowest mean error with 0.127, which indicates that ACN-LSTM is effective in univariate time series classification.
Association between multiple vitamins and bone mineral density: A population- based study in the NHANES from 2005 to 2006
Authors: Zhang Ruyi , Huang Qin , Su Guanhua , Wei Muhong , Cui Yuan , Zhou Haolong , Song Wenjing , Di Dongsheng , Liu Junan , Wang Qi
Published: August 2022

Background
Bone mineral density (BMD) alterations in response to multivitamin exposure were scarcely studied. Our study assessed the association of coexposure to six types of vitamins (i.e., vitamins B12, B9, C, D, A, and E) and BMD measurements among US adults.
Methods
Data were collected from the participants aged ≥ 20 years (n = 2757) in the U.S. National Health and Nutrition Examination Surveys (NHANES) from 2005 to 2006. Multiple linear regression, restricted cubic splines, principal component analysis (PCA) and weighted quantile sum (WQS) regression were performed for statistical analysis.
Results
Circulating levels of vitamins B12 and C were positively associated with BMDs, and an inverted L-shaped exposure relationship was observed between serum vitamin C and BMDs. The PCA identified two principal components, one for “water-soluble vitamins,” including vitamins B12, B9, and C, and the other one for “fat-soluble vitamins,” including vitamins A, D, and E. The former was positively associated with total femur (β = 0.009, 95%CI: 0.004, 0.015) and femoral neck (β = 0.007, 95%CI: 0.002, 0.013) BMDs, and the latter was negatively associated with BMDs with non-statistical significance. The WQS index constructed for the six vitamins was significantly related to total femur (β = 0.010, 95%CI: 0.001, 0.018) and femoral neck (β = 0.008, 95%CI: 0.001, 0.015) BMDs, and vitamins B12 and C weighted the most. The WQS index was inversely related to BMDs with non-statistical significance, and vitamins E and A weighted the most.
Conclusion
Our findings suggested a positive association between water-soluble vitamin coexposure and BMD, mainly driven by vitamins B12 and C, and a suggestive negative association between fat-soluble vitamin coexposure and BMD, mainly driven by vitamins E and A. And there was an inverted L-shaped exposure relationship between vitamin C and BMD.
A propensity score matching study of totally robotic Right Hemicolectomy versus robot-assisted Right Hemicolectomy
Authors: Jin Qianqian , Long Dongju , Liu Chao , Jiang Yuhong , Zhou Weihan , Yao Hongliang , Liu Kuijie
Published: August 2022

Objective
To compare and analyze the differences in safety, feasibility and short-term efficacy between robot-assisted and totally robotic surgery in Right Hemicolectomy.
Methods
A retrospective analysis was conducted on the clinical data of 184 patients who underwent right hemicolectomy in The Second Xiangya Hospital of Central South University from July 2016 to December 2021. 148 patients were matched (including 74 cases of robot-assisted right hemicolectomy (TRAH) and 74 cases of totally robotic right hemicolectomy (TRRH)). The general information, surgical and pathological results and complications of patients were collected and analyzed.
Results
The incision length was 5.14 ± 0.60cm in the robot-assisted group 4.74 ± 0.55cm in the totally robotic group (p < 0.001). The blood loss was 86.28 ± 52.57 ml in the robot-assisted group and 69.19 ± 44.78 ml in the totally robotic group (p = 0.035).The operative time of the robot-assisted group was 197.50 (171.25, 242.25) min, and that of the totally robotic group was 160.00 (145.00, 188.75) min (p < 0.001).The postoperative hospital stay was 11.18 ± 4.32 days in the robot-assisted group and 9.53 ± 4.42 days in the totally robotic group (p = 0.023). NRS pain scores were 3.05 ± 0.23 for the robot-assisted group and 2.96 ± 0.26 for the totally robotic group (p = 0.019). The extraction time of abdominal drainage was 7.54 ± 1.44 days in the robot-assisted group and 7.00 ± 1.25 days in the totally robotic group (p = 0.016). postoperative complications in the robot-assisted group were as follows: Urinary retention 1 (1.4%), chylous fistula 1 (1.4%), wound complications 3 (4.1%), postoperative intestinal obstruction 1 (1.4%), postoperative anastomosis 3 (4.1%), other complications 4 (5.4%);postoperative complications in the totally robotic group included 0 cases of urinary retention, 7 cases of chylous fistula (9.3%), 1 case of wound complication (1.3%), 0 cases of postoperative intestinal obstruction, 2 cases of postoperative anastomotic complications (2.7%), and 0 cases of other complications.
Conclusions
Complete robotic right hemicolectomy in the hands of an experienced colorectal surgeon is safe and feasible. Compared with robot-assisted right hemicolectomy, the totally robotic right hemicolectomy group has certain advantages in incision length, operative time, intraoperative blood loss, postoperative hospital stay, first exhaust time, first liquid diet time, Time of drainage tube removal, NRS pain score and postoperative complications.
Experimental studies and analytical analysis of thermophysical properties of Ethylene glycol – water based nanofluids dispersed with multi walled carbon nanotubes
Authors: Dosodia Abhishek , Srin V. , Jain A. K , Babu M Saratchandra , Teja S Bhanu
Published: August 2022

The current study examines the thermal conductivity and dynamic viscosity of ethylene glycol–water solutions comprising oxidised multiwalled carbon nanotubes. The Mouromtseff number (Mo) is used to estimate the heat transfer characteristics of nanofluids based on their physico-thermal properties. As a base fluid, ethylene glycol - water mixtures are taken in all volume proportions, from 100% to zero percent, for use in both automotive and solar thermal applications. Oxidized MWCNTs in weight fractions of 0.05, 0.1, 0.25, and 0.5 are used to produce the best stability in Ethylene glycol-Water mixtures. The stability of nanofluids was monitored for two months using UV-Vis spectroscopy. Adding MWCNTs to the base fluids results in a significant increase in thermal conductivity between 15% and 24%. In order to derive correlations between thermal conductivity and dynamic viscosity, a total of 1500 data points were collected for all possible combinations of temperature, weight fraction, and ethylene glycol %. from analysis using Mouromtseff number (Mo), it was found that under turbulent flow, low concentration dilute nanofluids were shown to be the most effective heat transfer medium.
Association Between Obesity and Recent and Ever Suicide Attempt Among Adults in the United States
Authors: Iwatate Eriko , Atem Folefac D. , Jones Eric C. , Hughes Jennifer L. , Yokoo Takeshi , Messiah Sarah E.
Published: August 2022

Purpose
The purpose of this cross-sectional study was to investigate whether obesity is associated with suicide attempt in a nationally representative sample of U.S. adults.
Methods
From the 2004–2005 National Epidemiologic Survey of Alcohol and Related Conditions Wave 2 data (n = 34,653 adults), survey responses were extracted on suicide attempt (ever, recent [≤ 2 years]), demographic (age, sex, race/ethnicity), mental disorders (internalizing, personality, substance abuse), and psychosocial factors (e.g., abuse, trauma, sexual identity). Current body mass index (BMI) categorized participants as obese (≥ 30 kg/m2) or non-obese (< 30 kg/m2). Odds ratio [95% confidence interval] of suicide attempt by obesity status was calculated by logistic regression, while adjusting for mental health, demographic, and psychosocial confounders.
Results
Ever and recent suicide attempt prevalence was 3.4% and 3.1%, respectively, and the obesity prevalence 28%. Compared to non-obese adults, obese adults were 1.43 [1.20–1.69] times and 1.40 [0.90–2.18] times more likely to have ever, and recently, attempted suicide, respectively. Among the obese, middle-age (36–55 years) adults were 0.64 [0.31–0.92] times less likely to have ever-attempted suicide than older (> 55 years) adults. Only 15% of the obesity’s association with lifetime suicide attempt was mediated by mental illnesses.
Conclusion
Current-obesity is associated with lifetime suicide attempt among U.S. adults, even after adjustment for mental health, demographic, and psychosocial confounders. Further research on the temporality and causality of this association is needed.
LAYN acts as a prognostic biomarker in ovarian cancer by engaging T cell exclusion and dysfunction
Authors: Li Le , Ma Haiyan , Song Changxin
Published: August 2022

Background
Ovarian cancer (OV) is one of the commonest gynecological cancer, especially in the developed world. Layilin (LAYN) is associated with multiple types of cancer. However, it remains unclear about LAYN’s underlying roles and potential mechanisms in ovarian cancer.
Methods
The expression status of LAYN and clinic information of patients in OV were investigated using The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases.
Results
High expression of LAYN forecasted a shorter survival time in all OV datasets we used, indicating high LAYN expression was significantly associated with poor prognosis in OV patients. Bioinformatic analyses showed that LAYN expression level was an independent factor associated with OV prognosis. We also proved the significant association of LAYN expression level with T cell exclusion and resistance to immune checkpoint blockade (ICB). Further analyses revealed that LAYN may play its role on tumor immunity through the TGF-beta signaling pathway.
Conclusions
This is the first study to reveal the molecular functions of LAYN in OV. Our study suggests that overexpressed LAYN might boost T cell exclusion and ICB resistance by activating TGF-beta signaling pathway, resulting in a poor prognosis for OV patients. This study shed a light on understanding potential prognostic biomarkers and therapeutic targets in OV.
Assessing Covid 19 Vaccine Side Effects among Syrian Private University Staff and Students
Authors: Othman Kassem , Khalifeh Muhammad , Mohammad Yousser
Published: August 2022

Introduction:
Since 2019 coronavirus was declared a pandemic, there has been no doubt that a vaccine is the ideal protocol to combat it. Within a year, only a handful of COVID-19 vaccines had been developed and licensed. This initiative in developing vaccines has shown many uncertainties and doubts about the efficacy and safety of these vaccines. This study aimed to assess side effects and perceptions after COVID-19 vaccination in Syria.
Methods
A cross-sectional study was conducted using a self-administered and self-filled questionnaire on a sample of Syrian Private University employees and students who received the COVID-19 vaccine in Damascus, Syria. Chi-square test was used to study the relationship between study variables. A value of p > 0.05was adopted as statistical significance.
Results
Out of 600 participants, 61.3% were male and 38.7% were female. 10% of the staff was in the university, and most of the students were from 32% College of Human Medicine, 14.7% College of Dentistry and 12.7% from College of Computer Engineering respectively. The main vaccines received by the sample were Sinopharm (27.3%), AstraZeneca (27.3%), Sputnik v/Sputnik Lite (17.3%), and Pfizer (16%). The majority, 38.7%, reported experiencing mild side effects after vaccination. The results showed a statistically significant relationship between the number of doses received by the sample and the side effects of the vaccine. The results also showed a statistically significant relationship between the type of vaccine and the side effects of vaccination.
Conclusion
The current study confirmed that the authorized COVID-19 vaccines are safe and that vaccination reduces subsequent infection with COVID-19. Most of the side effects after vaccination were non-existent or mild to moderate. They are signs that the body's immune system is building protection. Expected severe cases may require further medical attention or even hospitalization.
Van Hove Singularity in Graphene Nanowrinkle Grown on Ni(111) Generated by Pseudo One-Dimensional Electron Confinement
Authors: Ahn Jong-Guk , Kim Jee Hyeon , Lee Minhui , Kim Yousoo , Jung Jaehoon , Lim Hyunseob
Published: August 2022

A graphene nanowrinkle (GNW) formed on a Ni substrate, with a width below 5 nm, exhibits a unique feature (van Hove singularities (vHS)) in its electronic structure, owing to the one-dimensional (1D) electron confinement in GNWs. Considering that the 1D electron confinement effect normally appears when the electron motion is isolated in a 1D structure with the insulator-surrounding environment, the experimental observation of vHS in the electronic structure of GNW wedged between metallic graphene sheets has been regarded as extraordinary. Density functional theory calculations were systematically performed and revealed the origin of the 1D quantum confinement in GNW on the Ni substrate, which originated from the crucial role of chemisorption-like interaction between the graphene sheet and Ni surface in spatially separating the π-conjugated state of GNW from that of the graphene sheet. A series of standing waves corresponding to “the 1D particle-in-a-box model” was confirmed by computationally obtained charge densities of GNW. These results demonstrated that the graphene–GNW–graphene on the Ni substrate served a sufficient potential to lead to 1D-electron confinement. Our investigations provide a deeper understanding of the electronic structure in pseudo-1D materials and suggest a novel approach for modulating the electronic structure without chemical modification or complicated etching to break the C–C bond to produce graphene-based 1D nanomaterials, e.g., graphene nanoribbon.
Exploring the significance of RNA N6 methyladenosine regulatory factor in the diagnosis and subtype classification of chronic obstructive pulmonary disease based on GEO database
Authors: Pingan Zhang , Gao Na , Li Xiaoning , Wu Jianjun
Published: August 2022

N6 methyladenosine (m6A) is a very rich mRNA modifier, which plays animportant role in biological processes such as lipid metabolism, autophagy,macrophage activity and inflammatory response.However, the role of m6A regulatorin COPD remains unknown.In this study, the expression values of 23 m6Amethylation regulators were obtained by analyzing the gene expression matrix ofCOPD patients and normal controls in GSE76925 data set.Eleven candidate m6Aregulators were selected by random forest model to construct nomination graphmodel and predict the risk of COPD.The decision curve found that patients couldbenefit from the nomination model constructed.By consensus cluster analysis, m6Aregulators in COPD patients were divided into two subtypes (clusterA andclusterB) .The m6A pattern was quantified by principal component analysis algorithm.It was found that the m6A score of patients in clusterA was higher than that ofclusterB.Differential genes (DEGs) were screened by m6A typing and the differentialgenes were analyzed by Kyoto genome and genome Encyclopedia (KEGG). It wasfound that the differential genes were mainly enriched in NF-kB and TNF signalpathway.In addition, through gene and immune cell correlation analysis, it was foundthat the patients in m6A clusterB were related to the immunity dominated byneutrophil and eosinophil traps,however the patients in clusterA are related to theimmunity dominated by monocyte traps.Therefore, the discovery of m6A patternthrough m6A typing related genes and immune cells may be a new strategy to guidethe treatment of COPD.
Comparative study on Seroprevalence and Associated Risk factors of brucella Infection among sheep, goat and cattle in Somalia.
Authors: Ismail Abdulgani Huruse , Salman Adil Mohamed Ahmed
Published: August 2022

A cross-sectional Seroprevalence study using Multistage-sampling techniques, was conducted from the period between February 2019 to June 2020 at two livestock export quarantine stations and Livestock markets located in Bossaso, Somalia, to determine the Seroprevalence and associated risk factor of ruminant’s brucellosis. A total of 1068 sera samples were screened for Brucella antibodies using the Rose Bengal plate test, all-positive Serum samples and 80% negative samples with RBPT from sheep and goats and 50% negative sample from cattle were further tested using iELISA. The overall Seroprevalence rate of brucellosis in the current study was 1% and 1.84% using RBPT and i-ELISA respectively in Goats while 9.5% and 9% were positive in cattle using RBPT and i-ELISA respectively but there were no positive samples for sheep by both test of (RBPT) and (i-ELISA). The most significant Associated risk factors were species, castration and other risk factors such as age and Sex can affect status of brucellosis but their contribution are statistically insignificant.
Proxy Signcryption Algorithm for Interdomain Authentication in Wireless Mesh Networks
Authors: Qamar Shamimul
Published: August 2022

Authentication delay is main requirement for handoff in wireless mesh networks. When mobile client moves from one domain to another. In order to solve the problems, we propose an algorithm for handoff in Wireless Mesh Networks. pre-authentication are done by mobile station itself up to the next access point. Neighbor graph is used for maintaining and dynamically identifying the mobile topology of the network. Proxy signcryption scheme is applied between the Mesh Node (MN) and mobile client (MC) for the period of inter-domain authentication. To make sure security, the authentication messages are encrypted while transmitted between mobile client and mesh nodes and signed in an integrated fashion such that the communicated message is expressed as signcrypted. Simulation’s output shows, that the algorithm strengthen security of network .
Microcracks as tooth structural element: revealed by X-ray tomography and machine learning
Authors: Dumbryte Irma , Narbutis Donatas , Vailionis Arturas , Juodkazis Saulius , Malinauskas Mangirdas
Published: August 2022

Although teeth microcracks have long been considered more of an aesthetic problem, their exact role in tooth structure and impact on its functionality is still unknown. The possibility to use X-ray micro-computed tomography for three-dimensional (3D) non-destructive tooth visualization has shown unique morphological and structural features of microcracks that previously could not be detected with two-dimensional analysis techniques. We present 3D evaluation of four healthy (2 with and 2 without visible microcracks on the buccal surface) extracted human teeth, scanned with ZEISS Xradia 520 Versa and segmented with convolutional neural network to identify enamel, dentin, and cracks. An intricate star-shaped network of microcracks was found to cover most of the inner tooth with the main crack planes arranged radially in two almost perpendicular directions, disclosing the crack as a planar rather than a threaded structure. The interconnected network of microcracks detected inside a healthy tooth suggests that the cracks could be considered as one of the structural and possibly functional (i.e. redistribution of forces) elements of the tooth, relevant for its integrity and functionality.
Long-term loss of coral reef in the Gulf of Aqaba estimated from historical aerial images
Authors: Topel Elad , Lehahn Yoav
Published: August 2022

Located at the northern tip of the Red Sea, the Gulf of Aqaba coral reef, is highly susceptible to anthropogenic pressure associated with the massive development of the two neighbor cities of Eilat and Aqaba. Over the years the has been extensively studied in a umber of research and monitoring programs, which provide detailed information on a variety ecological,physiological, biogeochemical and physical variables. Due to the local nature of these surveys, while the state of the reef at specific times and locations is very well characterized, long term changes in the reef as a whole are hardly documented. Here, through analysis of historical aerial images, we address one of the most important aspects of this knowledge gap, and quantify how much coral reef were lost due to human activity with respect to a baseline level prior to the establishment of the City of Eilat in 1949. Our results show that through construction of infrastructures, human activity has led to the loss of more than 4,810 m2 of coral reef, either directly by the construction (most importantly the Eilat Port) or indirectly by changing environmental conditions, which in turn damage the reef - for example by intensifying accumulation of sand on top of it. Our results show that historical aerial images can provide a unique source of information on the spatial characteristics of marine, coastal and terrestrial systems prior to the era of Earth observation satellites.
Crack formation in chill block melt spinning solidification process: a comparative analysis using OpenFOAM®
Authors: Pagnola Marcelo , Barceló Francisco , Useche Jairo
Published: August 2022

The application of FeSiB family magnetic materials in electrical or electronic industry has significantly increased owing to the development of amorphous and nanocrystalline metallic glasses using melt spinning and chill block melt spinning technology that involves a rotating metal wheel with a high rotation speed. With this technique, a thin ribbon is obtained owing to the jet of liquid metal that is expelled from a casting nozzle at high pressure and temperature over the outer surface of the wheel. The cooling rates that can be achieved lead to disorder in the crystalline lattice of the metal, which is dependent on the chemical composition. As soon as the material jet is expelled by the nozzle, turbulence can occur in the solidification puddles. This generates defects and cracks in the solidification profile. In this study, numerically simulated Ad Hoc events in OPENFOAM® are comparatively examined using a real process.
Effects of Calcium Carbonate on Ammonium Assimilation by Tomato Seedlings1
Authors: Pierpont Robert A. , Minotti Peter L.
Published: August 2022

Seedlings of tomato (Lycopersicon esculentum Mill.) (15 to 22 days old) exposed to unbuffered solutions containing N solely in the NH4 form showed poorly developed, thickened, less branched, discolored root systems, marginal necrosis of some leaves, wilting, particularly dark green foliage, and restricted growth. Calcium carbonate at 0.5 g/liter alleviated NH4 toxicity and restricted the accumulation of free NH4 in roots, bleeding sap, and shoots even though NH4 uptake rates were accelerated by CaCO3. Thus, the beneficial effect was related to enhanced NH4 assimilation. Roots contained an active NADH-specific L-glutamate dehydrogenase, but in vitro activity was correlated with internal NH4 content and, therefore, did not reflect actual NH4 assimilation rates during experimental periods.
Ultraviolet Radiation as a Factor in Solar Injury and Vein Tract Browning of Cantaloupes1
Authors: Lipton Werner J.
Published: August 2022

Near ultraviolet radiation appears to be largely responsible for solar injury (SI) and vein tract browning (VTB) of cantaloupes (Cumis melo L., Reticulatus group, cv. PMR 45) grown under field conditions in the San Joaquin Valley of California. Incidence and severity of SI were substantially reduced when near UV flux impinging on the fruits at solar noon was reduced to 21 Wm-2 or less and especially when wavelengths below 320 nm were excluded by the use of plastic UV filters. VTB was reduced when UV flux was 12 Wm-2 or less or when wavelengths below 320 nm were excluded. In cantaloupes, near UV appears to directly induce SI but to indirectly induce VTB, a postharvest disorder, by accelerating aging of surface tissues.