bluuebunny/crossref_metadata_2025 huggingface dataset:
Vitamin E (α-Tocopherol) Does Not Ameliorate the Toxic Effect of Bisphenol S on the Metabolic Analytes and Pancreas Histoarchitecture of Diabetic Rats
Authors: Peña-Corona Sheila I. , Vargas-Estrada Dinorah , Chávez-Corona Juan I. , Mendoza-Rodríguez C. Adriana , Caballero-Chacón Sara , Pedraza-Chaverri José , Gracia-Mora María Isabel , Galván-Vela Diana Patricia , García-Rodríguez Helena , Sánchez-Bartez Francisco , Vergara-Onofre Marcela , Leyva-Gómez Gerardo
Published: July 2023

This study investigated whether the coadministration of vitamin E (VitE) diminishes the harmful effects provoked by plasticizer bisphenol S (BPS) in the serum metabolites related to hepatic and renal metabolism, as well as the endocrine pancreatic function in diabetic male Wistar rats. Rats were divided into five groups (n = 5–6); the first group was healthy rats (Ctrl group). The other four groups were diabetic rats induced with 45 mg/kg bw of streptozotocin: Ctrl-D (diabetic control); VitE-D (100 mg/kg bw/d of VitE); BPS-D (100 mg/kg bw/d of BPS); The animals from the VitE + BPS-D group were administered 100 mg/kg bw/d of VitE + 100 mg/kg bw/d of BPS. All compounds were administered orally for 30 days. Body weight, biochemical assays, urinalysis, glucose tolerance test, pancreas histopathology, proximate chemical analysis in feces, and the activity of antioxidants in rat serum were assessed. The coadministration of VitE + BPS produced weight losses, increases in 14 serum analytes, and degeneration in the pancreas. Therefore, the VitE + BPS coadministration did not have a protective effect versus the harmful impact of BPS or the diabetic metabolic state; on the contrary, it partially aggravated the damage produced by the BPS. VitE is likely to have an additive effect on the toxicity of BPS.
Bisphenol A and Bisphenol S in Hemodialyzers
Authors: Haq Zahin , Wang Xin , Cheng Qiuqiong , Dias Gabriela F. , Moore Christoph , Piecha Dorothea , Kotanko Peter , Ho Chih-Hu , Grobe Nadja
Published: July 2023

Bisphenol A (BPA)-based materials are used in the manufacturing of hemodialyzers, including their polycarbonate (PC) housings and polysulfone (PS) membranes. As concerns for BPA’s adverse health effects rise, the regulation on BPA exposure is becoming more rigorous. Therefore, BPA alternatives, such as Bisphenol S (BPS), are increasingly used. It is important to understand the patient risk of BPA and BPS exposure through dialyzer use during hemodialysis. Here, we report the bisphenol levels in extractables and leachables obtained from eight dialyzers currently on the market, including high-flux and medium cut-off membranes. A targeted liquid chromatography–mass spectrometry strategy utilizing stable isotope-labeled internal standards provided reliable data for quantitation with the standard addition method. BPA ranging from 0.43 to 32.82 µg/device and BPS ranging from 0.02 to 2.51 µg/device were detected in dialyzers made with BPA- and BPS-containing materials, except for the novel FX CorAL 120 dialyzer. BPA and BPS were also not detected in bloodline controls and cellulose-based membranes. Based on the currently established tolerable intake (6 µg/kg/day), the resulting margin of safety indicates that adverse effects are unlikely to occur in hemodialysis patients exposed to BPA and BPS quantified herein. With increasing availability of new data and information about the toxicity of BPA and BPS, the patient safety limits of BPA and BPS in those dialyzers may need a re-evaluation in the future.
Occurrence of Types A and B Trichothecenes in Cereal Products Sold in Romanian Markets
Authors: Macri Adrian Maximilian , Nagy Andras-Laszlo , Daina Sorana , Toma Diana , Pop Ioana Delia , Nadăș George Cosmin , Cătoi Adriana Florinela
Published: July 2023

In view of the frequent occurrences of mycotoxins in cereals, this study assessed the presence of trichothecenes in 121 samples from Romanian markets. These samples were divided into five groups based on product type: (1) bread and bakery products containing white flour, (2) half-brown bread with whole wheat flour, (3) brown bread containing rye flour, (4) pasta, and (5) raw wheat. Gas Chromatography-Mass Spectrometry was used to detect 13 different mycotoxins, which included the Type A compounds HT-2 toxin and T-2 toxin, as well as the Type B compounds deoxynivalenol and nivalenol. Results indicated trichothecene contamination in 90.08% of our samples, with deoxynivalenol predominating by at least 78% in each examined group. Co-occurrence of three or four trichothecenes were found in 23.85% of our samples. Our study underscores the necessity of consistent monitoring of staple foods to prevent the intake of harmful trichothecenes by consumers.
Adherence and Toxicity during the Treatment of Latent Tuberculous Infection in a Referral Center in Spain
Authors: Puyana Ortiz Juan David , Garcés Rodríguez Andrea Carolina Garcés , Aznar María Luisa , Espinosa Pereiro Juan , Sánchez-Montalvá Adrián , Martínez-Campreciós Joan , Saborit Nuria , Rodrigo-Pendás José Ángel , García Salgado Guadalupe , Broto Cortes Claudia Broto , Delcor Nuria Serre , Oliveira Inés , Treviño Maruri Begoña Treviño , Ciruelo Diana Pou , Salvador Fernando , Bosch-Nicolau Pau , Torrecilla-Martínez Irene , Zules-Oña Ricardo , Tórtola Fernández María Teresa Tórtola , Molina Israel
Published: July 2023

The screening and treatment of latent tuberculosis infection (LTBI) in countries with a low incidence of TB is a key strategy for the elimination of tuberculosis (TB). However, treatment can result in adverse events (AEs) and have poor adherence. This study aimed to describe treatment outcomes and AEs for LTBI patients at two departments in Vall d’Hebron University Hospital in Barcelona, Spain. A retrospective study was conducted on all persons treated for LTBI between January 2018 and December 2020. Variables collected included demographics, the reason for LTBI screening and treatment initiation, AEs related to treatment, and treatment outcome. Out of 261 persons who initiated LTBI treatment, 145 (55.6%) were men, with a median age of 42.1 years. The indications for LTBI screening were household contact of a TB case in 96 (36.8%) persons, immunosuppressive treatment in 84 (32.2%), and recently arrived migrants from a country with high TB incidence in 81 (31.0%). Sixty-three (24.1%) persons presented at least one AE during treatment, and seven (2.7%) required definitive discontinuation of treatment. In the multivariate analysis, AE development was more frequent in those who started LTBI treatment due to immunosuppression. Overall, 226 (86.6%) completed treatment successfully. We concluded that LTBI screening and treatment groups had different risks for adverse events and treatment outcomes. Persons receiving immunosuppressive treatment were at higher risk of developing AEs, and recently arrived immigrants from countries with a high incidence of TB had greater LTFU. A person-centered adherence and AE management plan is recommended.
Inferring Evolutionary Timescale of Omsk Hemorrhagic Fever Virus
Authors: Bondaryuk Artem N. , Belykh Olga I. , Andaev Evgeny I. , Bukin Yurij S.
Published: July 2023

Until 2020, there were only three original complete genome (CG) nucleotide sequences of Omsk hemorrhagic fever virus (OHFV) in GenBank. For this reason, the evolutionary rate and divergence time assessments reported in the literature were based on the E gene sequences, but notably without temporal signal evaluation, such that their reliability is unclear. As of July 2022, 47 OHFV CG sequences have been published, which enables testing of temporal signal in the data and inferring unbiased and reliable substitution rate and divergence time values. Regression analysis in the TempEst software demonstrated a stronger clocklike behavior in OHFV samples for the complete open reading frame (ORF) data set (R2 = 0.42) than for the E gene data set (R2 = 0.11). Bayesian evaluation of temporal signal indicated very strong evidence, with a log Bayes factor of more than 5, in favor of temporal signal in all data sets. Our results based on the complete ORF sequences showed a more precise OHFV substitution rate (95% highest posterior density (HPD) interval, 9.1 × 10−5–1.8 × 10−4 substitutions per site per year) and tree root height (416–896 years ago) compared with previous assessments. The rate obtained is significantly higher than tick-borne encephalitis virus by at least 3.8-fold. The phylogenetic analysis and past population dynamics reconstruction revealed the declining trend of OHFV genetic diversity, but there was phylogenomic evidence that implicit virus subpopulations evolved locally and underwent an exponential growth phase.
Genome Variability of Infectious Bronchitis Virus in Mexico: High Lineage Diversity and Recurrent Recombination
Authors: Marandino Ana , Mendoza-González Lizbeth , Panzera Yanina , Tomás Gonzalo , Williman Joaquín , Techera Claudia , Gayosso-Vázquez Amanda , Ramírez-Andoney Vianey , Alonso-Morales Rogelio , Realpe-Quintero Mauricio , Pérez Ruben
Published: July 2023

The avian infectious bronchitis virus (IBV) is a coronavirus that mutates frequently, leading to a contagious and acute disease that results in economic losses to the global poultry industry. Due to its genetic and serological diversity, IBV poses a challenge in preventing and controlling the pathogen. The full-length S1 sequence analysis identifies seven main genotypes (GI–GVII) comprising 35 viral lineages. In addition to the previously described lineage, a new GI lineage (GI-30) and two lineages from novel genotypes (GVIII-1 and GIX-1) have been described in Mexico. To prevent the spread of IBV outbreaks in a specific geographic location and select the suitable vaccine, it is helpful to genetically identify the circulating IBV types. Moreover, sequencing genomes can provide essential insights into virus evolution and significantly enhance our understanding of IBV variability. However, only genomes of previously described lineages (GI-1, GI-9, GI-13, and GI-17) have been reported for Mexican strains. Here, we sequenced new genomes from Mexican lineages, including the indigenous GI-30, GVIII-1, and GIX-1 lineages. Comparative genomics reveals that Mexico has relatively homogenous lineages (i.e., GI-13), some with greater variability (i.e., GI-1 and GI-9), and others extremely divergent (GI-30, GVIII-1, and GIX-1). The circulating lineages and intra-lineage variability support the unique diversity and dynamic of Mexican IBV.
Exploring the Differential Expression of a Set of Key Genes Involved in the Regulation and Functioning of the Stomach in the Post-Weaned Pig
Authors: Kiernan Dillon P. , O’Doherty John V. , Connolly Kathryn Ruth , Ryan Marion , Sweeney Torres
Published: July 2023

Despite playing a key role in digestion, there is only a broad characterization of the spatiotemporal development of the three glandular regions of the stomach (cardiac, fundic and pyloric) in the weaned pig. Hence, the objective of this experiment was to explore the differential expression (DE) of a panel of key genes within the three glandular regions of the stomach. Eight pigs were sacrificed at d 8 post-weaning, and three mucosal samples were collected from each stomach’s glandular regions. The expression of a panel of genes were measured using QPCR. The true cardiac gland region was characterized by increased expression of PIGR, OLFM4, CXCL8 and MUC2 relative to the two other regions (p < 0.05). The fundic gland region was characterized by increased expression of ATP4A, CLIC6, KCNQ1, HRH2, AQP4, HDC, CCKBR, CHIA, PGA5, GHRL and MBOAT4 compared to the two other regions (p < 0.05). The pyloric gland region was characterized by exclusive expression of GAST (p < 0.05). A transition region between the cardiac and fundic region (cardiac-to-oxyntic transition) was observed with a gene expression signature that resembles a cross of the signatures found in the two regions. In conclusion, unique gene expression signatures were identifiable in each of the glandular regions, with a cardiac-to-oxyntic transition region clearly identifiable in the post-weaned pigs’ stomachs.
Spatial Equilibrium Evaluation of the Water Resources in Tai’an City Based on the Lorenz Curve and Correlation Number
Authors: Lou Yanqian , Qiu Qingtai , Zhang Mingtai , Feng Zhonglun , Dong Jie
Published: July 2023

Water resource spatial equilibrium evaluations provide the bases for water resource utilization and allocation. To analyze the regional spatial water resource matching balance, this study constructed a water resource spatial matching model based on the Gini coefficient and Lorenz curve methods. To further reflect the influence of each subregion on the whole region, we combined the correlation number and Gini coefficient methods to propose the water resource spatial balance evaluation method. Herein, we constructed nine Lorenz curve pairs that matched the total water resources and total water use with cultivated land area, population, GDP (Gross Domestic Product) of the secondary industry, GDP (Gross Domestic Product) of the tertiary industry, and agricultural irrigation water consumption. Set pair analysis theory was applied to calculate sample correlation numbers and determine equilibrium levels, which were then compared to Gini coefficient method-based results for Tai’an city evaluation. The results showed that the total water consumption spatial equilibrium in Tai’an city from 2011 to 2020 was favorable, while the total water resource results for Tai’an city greatly differed, especially the balance between total water resources and GDPs of the secondary and tertiary industries, which should be further improved. In practice, quantitative analysis of the water resource spatial equilibrium state in Tai’an city is important for efficient water resource utilization and coordinated development of water resources and economic and social environments.
The Improved Reservoir Module of SWAT Model with a Dispatch Function and Its Application on Assessing the Impact of Climate Change and Human Activities on Runoff Change
Authors: Sheng Sheng , Chen Qihui , Li Jingjing , Chen Hua
Published: July 2023

Climate change and human activities significantly impact the hydrological cycle, particularly in regions with numerous large-scale reservoirs. Recognizing the limitations of the reservoir module in the original SWAT model, this study presents an improved reservoir module based on a dispatch function to enhance runoff simulation. Its performance is validated by simulating daily runoff in the Jinsha River Basin, China. The scenario simulation approach is employed to quantitatively analyze the influences of climate change and human activities on runoff. And downscaled Global Climate Models (GCMs) are utilized to predict runoff for the next three decades. The results show that (1) the improved SWAT model outperforms the original model in runoff simulation; (2) during the test period, reservoir regulations caused a reduction of 26 m3/s in basin outlet runoff, while climate change led to an increase of 272 m3/s; and (3) future changes in basin outlet runoff over the next 30 years exhibit a high level of uncertainty, ranging from −5.6% to +11.0% compared to the base period. This study provides valuable insights into the hydrological impacts of climate change and human activities, highlighting the importance of incorporating an improved reservoir module in hydrological modeling for more accurate predictions and assessments.
Response of Heavy Metals to Microseism in Coal Mining Subsidence Water of Huainan, China
Authors: Xu Liangji , Wang Jiayi , Zhang Kun
Published: July 2023

Coal mining causes surface subsidence, and the accumulated water body is constantly affected by the mining microseism in this process. Understanding the relationship between the subsided water quality and microseism plays a special role in assessing the environmental impact of mining activities. Based on sampling and monitoring, analyzing, and evaluating the Pansan subsided water area of Huainan, the influence of microseism activity on heavy metal elements in subsided water was verified. We found that the microseism effects decreased the contents of Zn, Pb, and Cu in the subsided water by 43.76%, 35.88%, and 28.83%, respectively, and Cd was not detected. The mechanism of heavy metal evolution in the water–sediment system under microseism factors was further explored by simulating experiments with similar materials. The results showed that the mining microseism increases the heavy metal adsorption capacity of suspended solids, and the dissolved heavy metals in water were transformed into suspended heavy metals. The heavy metals of subsided water eventually accumulate in the sediment, and the purpose of controlling heavy metal pollution can be achieved through regular cleaning of the bottom sediment.
Simulation Study of CH4 and N2O Emission Fluxes from Rice Fields in Northeast China under Different Straw-Returning and Irrigation Methods Based on the DNDC Model
Authors: Xu Dan , Zhang Zhongxue , Nie Tangzhe , Lin Yanyu , Li Tiecheng
Published: July 2023

In order to explore the long-term variation law of methane (CH4) and nitrous oxide (N2O) emissions from rice fields in cold regions under different straw-returning and irrigation methods, this study set up two irrigation methods, namely, conventional flooding and controlled irrigation, and two straw-returning quantities (0 t·hm−2 and 6 t·hm−2). Based on the field in situ test data, a sensitivity analysis of the main factors of the DNDC model affecting the emissions of CH4 and N2O from rice fields was conducted, and the emission fluxes of CH4 and N2O were calibrated and validated. Under different future climate scenarios (RCP4.5 and RCP8.5), greenhouse gas emissions from rice fields were simulated on a 60-year scale under different straw-returning and irrigation methods using the DNDC model. The results indicate that the DNDC model can effectively simulate the seasonal emission laws of CH4 and N2O from rice fields in cold regions under different straw-returning and irrigation methods. The simulated values have a significant correlation with the measured values (R2 ≥ 0.794, p < 0.05), and the consistency is controlled within 30%. The soil texture, soil organic carbon (SOC) content, annual average temperature, and straw-returning amount are sensitive factors for CH4 emissions from rice fields. The total nitrogen fertilizer application amount and SOC content are sensitive factors for N2O emissions from rice fields. Over the next 60 years, under the two different emission scenarios of RCP4.5 and RCP8.5, straw returning combined with control irrigation has a good coupling effect on the GWP of rice fields, and compared with conventional flooding without straw returning, the GWP of rice fields is reduced by 31.41% and 34.13%, respectively, and the SOC content in 0–20 cm soil layer is increased by 54.69% and 52.80%, respectively. Thus, it can be used as a long-term carbon sequestration and emission reduction tillage model for rice fields in Northeast China. The results of this study can provide a reference for a further regional estimation of greenhouse gas emissions from rice fields using models.
Growing Community Capacity in Energy Development Through Extension Education
Authors: Romich Eric , Ellzey Nancy
Published: July 2023

New energy policy, industry regulation, and market investment are influencing the development of renewable energy technologies, setting the stage for rural America to provide the energy of tomorrow. This article describes how Extension's renewable energy programming was implemented in two Ohio communities to engage elected officials and residents in learning applied aspects of renewable energy development. Through outreach and education, Extension can assist communities in making informed decisions about renewable energy projects. Reflecting on the impacts from renewable energy programming delivered in Ohio, the authors recommend that Extension systems across the country engage communities in renewable energy education.
The Blockbuster Biopic Bohemian Rhapsody as an Expression of Cinema/Music Synergy
Authors: Radošinská Jana , Rusňáková Lenka , Točená Zuzana , Schwarz Martin
Published: July 2023

The study focuses on Bohemian Rhapsody (2018, directed by Bryan Singer, later Dexter Fletcher), the biographical drama that reflects on the extraordinary lives and career patterns of the four members of the rock band Queen, predominantly the band’s frontman, Freddie Mercury. Given the fact that this feature film has changed the way we perceive the economic potential of biopics entirely, we offer an overview of some of the reasons why it was so successful in terms of the globalised film industry. The main objective of the study is to outline the biographical drama’s synergistic tendency in relation to the movie industry and the music business. Acknowledging Bohemian Rhapsody’s unprecedented global success, we work with the assumption that certain biographical dramas can, in fact, become globally popular, partly thanks to the fact that they utilise music as a nostalgia-driven narrative tool making portrayals of musicians deeper and more complex. The assumption is addressed via a theoretical reflection on the given topic and through a qualitative content analysis of the biographical drama Bohemian Rhapsody.
Authorship in Biomedical Science: On-line Survey Results and Analysis
Authors: HONG Suk-Young , YI Sang-Wook , KOO Young-Mo , CHO Eun-Hee
Published: July 2023

What would be the acceptable criteria for the authorship of research papers? In order to study this question, we analyze the relevant part of the results from the on-line survey that we performed to investigate the general attitudes of biomedical researchers as regards a number of issues of research ethics. The survey targeted the members of the Korean Society for Molecular and Cellular Biology, and 659 members responded. We ask questions such as who should be included as author, who is generally de facto included as author, and what are the problems in the decision of authorship. The results show that there are significant difference between Principal Investigators and research students in their responses, and that researchers in general tend to think the authorship is actually given more generously than it should be. We also examine the authorship criteria suggested by the International Committee of Medical Journal Editors(ICMJE), and its trend of changes. Finally, we discuss a few major issues Korean researchers facing when they decide authorship.
A Critical Review of Current Medical Ethics Education in Korea
Authors: KWON Ivo
Published: July 2023

There are numerous problems with the medical ethics education currently practiced in Korea. In the first place, there is a lack of consensus regarding the goals of medical ethics education. Some educators seek to promote morality or good character in medical students, while others focus on advanced bioethical issues such as euthanasia or organ transplantation. Secondly, there is confusion concerning teaching methods. Lectures, small group discussions, so called "dilemma discussions", PBL, TBL, and public service components are all used without any clear educational purpose and strategy. Thirdly, there are problems with evaluation; few know how to evaluate students' performance or measure the effects of medical ethics education.
In this article, I argue that the promotion of medical ethics competency based on the medical professionalism should be recognized as the ultimate goal of basic medical ethics education. Medical ethics competency is composed of knowledge, problem solving skills, and professionalism, and it covers three different domains: medical ethics, bioethics, and professional ethics. Instructional tools and methods should be constructed and implemented to achieve this goal of medical ethics competency, which will in turn help to promote medical professionalism in Korea.
Raising the Social Perception of Nursing and Proposing Its Methods in the Perspective of Heroism*
Authors: LEE Young-Jun , LEE Hwang
Published: July 2023

This article aims to study how to improve the social perception on nurses by exploring the relationship between nursing and heroism. Heroism science regards nursing as heroic by nature and encourages nurses to understand and carry out their potential through a recognition of heroic acts in nursing. Accepting such perspective, we claim that the awareness of nursing as heroism should be deeply permeated into our society because it helps nurses recover high self-esteem and reestablish their identity, act more courageously, and ultimately boost social wellness. And hero training contents or programs in nursing and legal safeguards for heroic acts of nurses are needed to be created and operated, and additionally, everyday nurse heroes should be actively discovered and widely known to the public.
The Ethics of COVID-19 Vaccine Allocation
Authors: FANG Yin-Hua , KIM Ock-Joo
Published: July 2023

Border controls and social distancing have proven effective in containing the spread of COVID-19, but the current pandemic will not end until herd immunity is achieved through the widespread use of vaccines. Given the importance of vaccines in overcoming this global health crisis, and the current imbalance between their supply and demand, ethical questions arise concerning how COVID-19 vaccines should be distributed. This article argues that the guiding objectives for the distribution of COVID-19 vaccines should be the reduction of inequality and the maximization of benefits through the use of clear and transparent criteria for vaccine prioritization. Allocating scarce medical resources such as vaccines is a long-term ethical challenge. Only an ethically sound and well-coordinated vaccine distribution plan can ensure fair access for those in need.
The System for Making Decisions to Forego Life-Sustaining Treatment: Results of a 2020 National Survey*
Authors: LEE Eun Young , HEO Jea Yeong , TAE Hyoi Jin , CHO Jung Sook
Published: July 2023

Since 2019, the Ministry of Health and Welfare and the National Agency for Management of Life-Sustaining Treatment has been conducting surveys of public awareness of the system for making decisions to forego life-sustaining treatment (LST). The purpose of these surveys is to ascertain public awareness of the system and to identify ways to improve it. In 2020, for the first time since the system’s implementation, a survey was conducted on those who used either Registry Agencies for Advance Directives or medical institutions with ethics committees established according to the system for making decisions to forego LST. The mobile user survey of 1,426 people was conducted from November 2 to 23, 2020. In this article, we derive five policy suggestions based on the survey results: (1) A public education program on the end of life should be developed; (2) Systematic consumer-tailored public relations strategies should be implemented to better promote the system. (3) Registry agencies and medical institutions should be encouraged to increase user accessibility to the system; (4) Counseling aids, such as explanatory materials and various information delivery tools, should be provided for better decision-making on LST; and (5) A communication channel should be opened with the public.
Nursing Ethics during COVID-19 Pandemic: Focusing on the Ethics of Care
Authors: KONG Byung-Hye
Published: July 2023

The ethic of care in nursing presupposes a narrative understanding of patients in vulnerable situations. This ethic has both has both reciprocal and protective ethical dimensions. The ethics of reciprocity guides the relationship between nurses and patients such that each influences the other toward a good life and thereby helps to create an ethical narrative. A protective ethic calls for protecting the patient’s identity and responding to predicaments in which the dignity of the person is threatened. In particular, nurses are sometimes asked to provide existential advocacy for their patients. Moreover, in the context of the COVID-19 pandemic, where patient safety is a top priority, nurses must understand the existential threats facing patients and provide holistic care as existential advocates for patients and their families. However, it may be too much to require constant dedication and sacrifice from nurses. This article argues that it is important to establish an institutional support system for staffing, professional education, and self-care so that nurses can practice holistic care as professionals, rather than as “angels” or “heroes”. The ethics of care can contribute to self-growth and professional development toward a good life for both patients and nurses.
Composition and properties of saliva in the mechanisms of dental caries development during the adaptation of school-age children of the indigenous and immigrant population in the Far North
Authors: Zyryanov B. N.
Published: July 2023

Aim. To study the composition and properties of saliva in the mechanisms of dental caries development in school-age children of indigenous and immigrant population during adaptation to the Far North.

Materials and methods. The prevalence and intensity of dental caries were determined in 315 school-age children of the indigenous and immigrant population of the Far North, and the content of ionized calcium, phosphorus, potassium, sodium, their coefficients, the rate of saliva secretion, the amount of its sediment, and the hydrogen index were studied in saliva. A total of 630 clinical and 3780 laboratory parameters were obtained.

Results. A violation of the composition and properties of saliva in immigrant children of the Arctic who have been living in this region for a long time has been revealed. This disorder contributes to the growth of dental caries in alien school-age children.

Conclusions. The composition and properties of saliva in the process of adaptation of alien children to the conditions of the Arctic play an important role in the mechanisms of dental caries development.
Analysis of the biocompatibility of various types of filling materials with the pulp-periodontal complex according to protein spectrum of gingival crevicular fluid
Authors: Ostanina D. A. , Archakov K. A. , Mitronin Yu. A. , Antonova O. A. , Mitronin A. V.
Published: July 2023

Relevance. In practical dentistry, composite materials, cements, amalgam and metal-free ceramics are used to restore defects in hard tissues of teeth. Research data indicate that the type of filling material can affect the state of the pulpperiodontal complex of the tooth and lead to its degenerative changes.

Aim. To study the state of the pulp-periodontal complex according to the protein spectrum of the gingival crevicular fluid of teeth filled with various types of restorative materials.

Materials and methods. In the course of the study, the gingival crevicular fluid of the teeth was taken from 4 groups of patients using absorbent paper points of size 20 according to ISO: group 1 (control) – healthy teeth (n = 32); group 2 – composite materials (n = 12); group 3 – amalgam (n = 11); group 4 – metal-free ceramics E-max (n = 9). The activity of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (AP) and lactate dehydrogenase (LDH) was studied in the obtained samples of gingival crevicular fluid using spectrophotometric analysis. Results. In the gingival fluid eluates, no statistically significant differences in the activity of ALT and AST enzymes were found between the studied groups. ALP activity in group 3 was 1.5 times higher than in groups 2, 4 and control, and the level of LDH in group 3 was 1.5 times higher than in groups 2, 4 and control.

Conclusion. It was found that composite material and E-max metal-free ceramics have the best biocompatibility with teeth tissues, and the greatest changes in the protein spectrum of gingival fluid were detected in amalgam fillings.
Indicadores das dimensões de burnout nas categorias de base do futebol amador
Authors: Pires Daniel Alvarez , Souza Fábio José Silva , De Souza Gilmar Nonato
Published: July 2023

A realidade do futebol amador apresenta diferenças consideráveis de ordem social e econômica em relação ao futebol de alto rendimento. Entretanto, percepção de esgotamento físico e mental, desvalorização e sentimentos de abandono podem ser observados em ambos os contextos. Esses elementos estão associados à manifestação da síndrome de burnout, compreendida como uma reação ao estresse crônico que pode ocasionar o abandono da atividade esportiva. Os objetivos do estudo foram mensurar as dimensões da síndrome de burnout em atletas das categorias de base do futebol amador e avaliar o efeito da variável idade na percepção de burnout. Participaram do estudo 110 atletas amadores, com idade média de 18,02±1,38 anos e idade média de início no futebol de 10,41±1,73 anos, sendo 49 da categoria sub 17 e 61 da categoria sub 20. Os participantes preencheram o Questionário de Burnout para Atletas (QBA) e um questionário sociodemográfico. Para a análise dos dados utilizou-se a estatística descritiva e o teste U de Mann-Whitney. O índice de significância adotado foi p
Exploring correlations between Picasso’s artworks and his personal contacts
Authors: Mallen Enrique , Meneses Luis
Published: July 2023

For a biographical artist like Pablo Picasso, exploring the correlation between specific individuals or events in his life and certain shifts in his style is a crucial step in understanding his artistic works. This article analyzes these correlations using information recorded on a MySQL database by the Online Picasso Project for over two decades. We exported the database to SQLite and extracted entities using Python and its BeautifulSoup library to analyze term frequency-inverse document frequency using the Gensim library. Our analysis has confirmed that the connections between artistic creations and biographical events do indeed exist.
ANALYSIS OF CHEMICAL LITERACY OF PROSPECTIVE TEACHER STUDENTS
Authors: Suandi Sidauruk  , Anggraeni Maya Erliza , Agtri Wulandari  , Omry Susanto Siregar  , Hernita Andriani
Published: July 2023

The Covid-19 pandemic is a virus that has spread and shocked the world. The Covid-19 pandemic has caused significant literacy and numeracy learning losses. Indonesian human resources are expected to be able to compete with other countries in the 21st century education era. Development of student literacy is very urgent and urgent which aims to encourage students to have skills that support responsiveness to changing times, including during the current Covid-19 pandemic. The characteristics of scientific literacy are very closely related to learning chemistry, namely understanding the nature of matter particles, chemical reactions, chemical laws and theories, and chemical applications in everyday life. Based on initial observations through empirical fact studies, students' literacy skills are still relatively low, while chemical literacy skills must be based on an understanding of the basic concepts of science/chemistry. In addition, the low ability of scientific literacy is due to the fact that the questions developed in schools are still not able to identify students' abilities. This study aims to determine differences in chemical literacy of prospective teacher students. The urgency of this research is to find out students' chemical literacy skills as a basic reference in developing appropriate chemistry learning tools. This type of research is descriptive research. The research subjects were prospective teacher students at Palangka Raya University. The research instruments used were 27 multiple choice questions and interview guide sheets based on the 2015 PISA scientific literacy framework on the dimensions of context, knowledge and competence. The results of the study show that in each dimension, two dimensions are in the low category and only literacy in the context aspect is in the medium category. The lowest literacy dimension is the ability to explain material/content knowledge (P.1).
The pilot study of the basic pharmacokinetic properties of pyrrolylcarnosine — the new pyrrolic derivative of dipeptide carnosine
Authors: Abaimov D. A. , Khutorova Anastasiya V. , Sariev A. K. , Kulikova O. I. , Belousova M. A. , Stvolinsky S. L. , Migulin V. A. , Fedorova T. N.
Published: July 2023

The experimental study of the pharmacokinetic characteristics of a new pyrrole derivative of carnosine, pyrrolylcarnosine, was carried out. Based on the results of the experiment, the basic pharmacokinetic parameters of the drug are expected. The tissues and organs bioavailability was studied. The tropism of pyrrolylcarnosine to the organs of elimination and the ability of pyrrolylcarnosine to penetrate into the heart muscle tissue were shown.
ASSESSMENT OF THE EFFECTIVENESS OF PUNCTURE INTERVENTIONS IN PATIENTS WITH SEPTIC COMPLICATIONS OF ACUTE PANCREATITIS
Authors: Boyko V. V. , Merkulov A. O. , Shevchenko J. M. , Tkach S. V. , Bilodid Ye. O. , Kulik I. A.
Published: July 2023

Summary. The results of minimally invasive puncture-drainage interventions in 56 patients with acute severe pancreatitis were analyzed. Indications for the implementation of puncture-drainage interventions were the presence of bulk fluid formations in the abdominal cavity and retroperitoneal space. These interventions were the first and only surgical intervention in 28 (50%) patients who recovered without any additional surgical procedures. The possibility of predicting the effectiveness of puncture-drainage interventions with the help of indicators included in the syndrome of systemic inflammatory reaction is determined.
The Influence of Digital Marketing on Purchase Intention with Brand Awareness as a Mediating Variable
Authors: Edwin William S.
Published: July 2023

This study examines the relationship of digital marketing to purchase intention, and the relationship of digital marketing to purchase intention mediated by brand awareness. The digital marketing variable has 4 indicators, namely information recombination, accessibility, navigation interaction, and speed. The next variable, namely brand awareness, has 4 variables, which are brand familiarity, knowing or having heard of the brand, brand knowledge, and advertising. The last variable, namely purchase intention, has 3 indicators, namely interest, presence, and information. In this study, researchers used a purposive sampling technique to collect respondent, the population used was Ciputra University Surabaya students from class 2018 and 2019 majoring in International Business Management, in total there are 213 respondents collected as the sample. In this study, it was found that digital marketing on purchase intention is insignificant, meanwhile the mediating relationship between brand awareness and digital marketing and purchase intention is significant. This study can clarify the inconsistency from various previous studies related to the relationship of digital marketing and purchase intention. In this study, significant results were found if the mediating variable which is brand awareness was added to the relationship between digital marketing and purchase intention variables.
The Effect of Product Quality and Service Quality on Consumer Repurchase Intention of Alami Restaurant & Catering Service with Customer Satisfaction as an Intervening Variable
Authors: Salsabila Nadia Khansa
Published: July 2023

This study examines the direct and indirect effects of product quality and service quality on the repurchase interest of Alami Restaurant & Catering Service consumers with customer satisfaction as an intervening variable. The variables studied were product quality (X1), service quality (X2), customer satisfaction (Y1), and repurchase interest (Y2). The respondents of this study were all customers of Alami Restaurant & Catering Service and this quantitative research distributed questionnaires to 270 customers of Alami Restaurant & Catering Service as respondents determined by purposive sampling techniques, namely customers who came directly to the restaurant and had made a minimum purchase once at the restaurant. The results found that 1) product quality has a positive and significant effect on customer satisfaction value of 0.000 p ≤ 0.05; 2) service quality of 0.000 p ≤ 0.05 has a positive and significant effect on customer satisfaction; 3) product quality has a positive effect on customer repurchase interest value 0.003 p ≤ 0.05 and 4) service quality has a positive and significant effect on repurchase interest value 0.000 p ≤ 0.05; and 5) product quality and service quality positively affect repurchase interest with partial mediation of customer satisfaction 0.000 p ≤ 0.05.
Analysis of The Influence of Facilities, Learning Environment, and Location on The Decision to Choose The Faculty Of Medicine, Universitas Ciputra
Authors: Peni Indri Reswari Mustika
Published: July 2023

This study aims to determine the effect of facilities, learning environment, and location on the decision to choose the Faculty of Medicine, University of Ciputra. The population in this study were 300xx medical students at Ciputra University. While the sample used amounted to 104 respondents with the sampling method is simple random sampling Based on the results of the analysis carried out using the multiple linear regression method, it can be seen that the learning environment factors and location factors have a significant effect on the decision to choose medical students in choosing the Faculty of Medicine, Ciputra University.
Balanced Scorecard Design at PT X Construction Services Company
Authors: Limanjaya Albert
Published: July 2023

This thesis aims to design a balanced scorecard for PT X, a family-owned construction company which has yet to implement a quantifiable performance evaluation system. The decision to use balanced scorecard is based on the company’s need to create an understanding of its strategy across the company ranks, and to help with strategy execution. This research is conducted based on qualitative methodology, with case study approach. Data collection is done through in-depth interview with the company’s director and managerial staff to better understand the company’s strategic objectives and to set targets based on company’s capability. Data analysis found 13 strategic objectives and 28 indicators across the four perspectives of balanced scorecard.
Designing Blue Ocean Strategy at UD Rejeki
Authors: Hermanto Hans
Published: July 2023

The property industry is an industry that has intense competition. The competition creates an oversupplied condition where there are more goods offered when compared to market demand. This condition causes market players in the property industry to tend to conduct price wars. This competition is also felt by UD Rejeki as one of the players in the property industry. In order to avoid this fierce competition, companies must present innovations. This research uses Blue Ocean Strategy as a tool to design strategies so that UD Rejeki can avoid market saturation and price wars, and become a sustainable company. The design of Blue Ocean Strategy in this study is designed through the Strategy Canvas, Value Innovation, and Four Action Frameworks. This research method uses interviews from various sources that have been selected using purposive sampling method. Interviews were conducted in a semi-structured manner and documentation was conducted using transcripts, photos, and voice recordings. Data validity and reliability were tested using source triangulation.
Análisis económico de la producción de maíz en Chiapas, México, en la región de la Frailesca
Authors: Ramírez Abarca Orsohe , Ibarra Zavala Darío Guadalupe , Gutiérrez Estrada Arcenio
Published: July 2023

En México uno de los cultivos de mayor trascendencia es el maíz, ya que representa una parte trascendental en el quehacer de los productores en el campo de mexicano, aunado a ser uno de los productos de mayor relevancia en la economía del ingreso de las unidades de producción, así como en la alimentación de las mismas familias en el sector rural. Las estadísticas del Sistema de Información Agroalimentaria de Consulta, reveló que en el país se sembraron 7.5 millones de hectáreas de las cuales se cosecharon 7.0 millones, lo que reflejó una pérdida de alrededor de 472,902.3 hectáreas, a pesar de ello el volumen de producción presentó una tasa de crecimiento de 1.5% del 2010 al 2021. El objetivo que se planteó fue cuantificar la rentabilidad privada de la producción de maíz en la región socioeconómica de la Frailesca en el estado de Chiapas, México, para lo cual se utilizó el instrumental metodológico de la Matriz de Análisis de Política (MAP), en donde el grano es el cereal más sobresaliente, los resultados que se obtuvieron revelaron que la producción por hectárea de maíz sigue siendo redituable cuando no se considera el costo de la tierra y en el momento en que ésta es incluida en los costos de producción se obtuvieron pérdidas, a pesar de ello, los productores siguen insertados en la actividad productiva en la región de estudio ya que forma parte de los productos básicos en la alimentación de la población.
Tratamiento y representación de datos provenientes de escalas tipo Likert
Authors: Machuca Yaguana Jonathan Alberto , Aldonado Machuca María Emilia M , Vinces Vinces Fabricio Vladimir
Published: July 2023

El presente trabajo de investigación aporta un modelo matemático con el cual se puede presentar de forma resumida los datos provenientes de instrumentos basados en escalas de tipo Likert. La fórmula se desarrolló con base en un proceso de normalización de datos y la característica de linealidad de este tipo de escalas. El modelo permite obtener un valor representativo para cada indicador de la pregunta sin importar el tamaño de la escala, con lo cual es posible generar gráficos estadísticos que permiten abstraer con facilidad los principales hallazgos de una investigación. El modelo también se destaca por generar valores acotados entre 0 y 1 con lo cual es posible establecer relaciones de comparación y orden entre los indicadores de la pregunta, con lo cual se facilita en gran medida el análisis cuantitativo de datos recabados mediante escalas de Likert.
Risk of Pancreatic Cancer and Use of Dipeptidyl Peptidase 4 Inhibitors in Patients with Type 2 Diabetes: A Propensity Score-Matching Analysis
Authors: Kim Mee Kyoung , Han Kyungdo , Kwon Hyuk-Sang , Yoo Soon Jib
Published: July 2023

Background: The effects of dipeptidyl peptidase 4 (DPP-4) inhibitors over the course of long-term treatment remain unclear, and concerns have been raised regarding the role of DPP-4 inhibitors in carcinogenesis in the pancreas. Earlier studies of pancreatic adverse events have reported conflicting results.Methods: This study analyzed Korean National Health Insurance Service data from January 2009 to December 2012. Patients who had type 2 diabetes mellitus and took two or more oral glucose-lowering drugs (GLDs) were included. Patients prescribed DPP-4 inhibitors (n=51,482) or other GLDs (n=51,482) were matched at a 1:1 ratio using propensity score matching. The risk of pancreatic cancer was calculated using Kaplan-Meier curves and Cox proportional-hazards regression analysis.Results: During a median follow-up period of 7.95 years, 1,051 new cases of pancreatic cancer were identified. The adjusted hazard ratio (HR) for DPP-4 inhibitor use was 0.99 (95% confidence interval [CI], 0.88 to 1.12) compared with the other GLD group. In an analysis limited to cases diagnosed with pancreatic cancer during hospitalization, the adjusted HR for the use of DPP-4 inhibitors was 1.00 (95% CI, 0.86 to 1.17) compared with patients who took other GLDs. Using the other GLD group as the reference group, no trend was observed for elevated pancreatic cancer risk with increased DPP-4 inhibitor exposure.Conclusion: In this population-based cohort study, DPP-4 inhibitor use over the course of relatively long-term follow-up showed no significant association with an elevated risk of pancreatic cancer.