bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of CYP1A1 variants on the risk of acute lymphoblastic leukemia: evidence from an updated meta-analysis
Authors: Frikha Imen , Frikha Rim , Medhaffer Moez , Charfi Hanen , Turki Fatma , Elloumi Moez
Published: March 2024

Objective

Our study aimed to investigate the association between cytochrome P450 1A1 (CYP1A1) polymorphisms (T3801C and A2455G) and acute lymphoblastic leukemia (ALL) risk, considering genetic models and ethnicity.

Materials and methods

PubMed, Embase, Web of Knowledge, Scopus, and the Cochrane electronic databases were searched using combinations of keywords related to CYP1A1 polymorphisms and the risk of ALL. Studies retrieved from the database searches underwent screening based on strict inclusion and exclusion criteria.

Results

In total, 2822 cases and 4252 controls, as well as 1636 cases and 2674 controls of the C3801T and A2455G variants of CYP1A1, respectively, were included in this meta-analysis. The T3801C polymorphism of CYP1A1 significantly increases the risk of ALL, particularly those observed in Asian and Hispanic populations, independent of age. Similarly, the A2455G polymorphism of CYP1A1 plays a significant role in the susceptibility to ALL in all genetic models, except the heterozygous form. This association was observed mainly in mixed populations and in both children and adults (except in the heterozygous model).

Conclusion

Our comprehensive analysis indicates that the T3801 and A2455G polymorphisms of CYP1A1 may increase the risk of ALL depending on ethnicity. Therefore, both variants should be considered promising biomarkers for ALL risk. Further large-scale investigations are necessary to assess other factors, such as gene-gene or gene-environment interactions.
Cognitive Linguistics and Language Evolution
Authors: Pleyer Michael , Hartmann Stefan
Published: March 2024

The evolution of language has developed into a large research field. Two questions are particularly relevant for this strand of research: firstly, how did the human capacity for language emerge? And secondly, which processes of cultural evolution are involved both in the evolution of human language from non-linguistic communication and in the continued evolution of human languages? Much research on language evolution that addresses these two questions is highly compatible with the usage-based approach to language pursued in cognitive linguistics. Focusing on key topics such as comparing human language and animal communication, experimental approaches to language evolution, and evolutionary dynamics in language, this Element gives an overview of the current state-of-the-art of language evolution research and discusses how cognitive linguistics and research on the evolution of language can cross-fertilise each other. This title is also available as Open Access on Cambridge Core.
Trans Epistemology and Methodological Radicalism: Un Œuf, But Enough
Authors: Cull Matthew J.
Published: March 2024

There have now been a few attempts in trans theory to give an account of trans epistemology (see Radi 2019; Meadow 2016; and Dickson 2021). I will suggest that despite an admirable goal—that of giving an epistemology that provides a methodologically radical and distinctively trans break from other contemporary epistemological theory—thus far no account has been successful. Instead, I suggest that, in the absence of a more satisfactory radical account of trans epistemology, we can think of trans epistemology as a methodologically moderate (though politically radical) extension of mainstream epistemology.
Consistent outer scaling and analysis of adverse pressure gradient turbulent boundary layers
Authors: Han Mingze , Ma Mingze , Yan Chao
Published: March 2024

Under adverse pressure gradient (APG) conditions, the outer regions of turbulent boundary layers (TBLs) are characterized by an increased velocity defect

$U_{e}-U$

, an outwards shift of the peak value of the Reynolds shear stress

$-\langle uv\rangle$

and an appearance of the outer peak value of the Reynolds normal stress

$\langle uu\rangle$

. Here

$U_{e}$

is the TBL edge velocity. Scaling APG TBLs is challenging due to the non-equilibrium effects caused by changes in the APG. To address this, the response distance of TBLs to non-equilibrium conditions is utilized to extend the Zagarola–Smits scaling

$U_{zs} = U_{e}({\delta ^{*} }/{\delta })$

and ensure that the original properties of the Zagarola–Smits scaling are maintained as

$Re \to \infty$

. Here

$\delta ^{*}$

is the displacement thickness and

$\delta$

is the boundary layer thickness. Based on the established correlation between

$U_{e}-U$

and

$-\langle uv\rangle$

, the scaling is extended to

$-\langle uv\rangle$

. Furthermore, considering the coupling relationship between Reynolds stress components, the scaling is extended to encompass each Reynolds stress component. The proposed consistent scaling is verified using five non-equilibrium databases and five near-equilibrium databases, successfully collapsing the data of the TBL outer region. The pressure gradient parameter

$\beta =({\delta ^{*} }/{\rho u_{\tau }^{2} }) ({\mathrm {d} P_{e} }/{\mathrm {d}\kern0.7pt x})$

of these databases spans two orders of magnitude. Here

$P_{e}$

is the boundary layer edge pressure,

$u_{\tau }$

is the friction velocity and

$\rho$

is the density. Finally, the influence of the APG on the inner and outer regions of TBLs is analysed using the mean momentum balance equation. The analysis suggests that the shift of the

$-\langle uv\rangle$

peak to the outer region under APG conditions is due to an insufficient inertia term near the inner region to balance the APG. It is observed that the APG promotes interaction between the inner and outer regions of TBLs, but the inner and outer regions still retain distinctive properties.
DUALITY FOR COALGEBRAS FOR VIETORIS AND MONADICITY
Authors: ABBADINI MARCO , DI LIBERTI IVAN
Published: March 2024

We prove that the opposite of the category of coalgebras for the Vietoris endofunctor on the category of compact Hausdorff spaces is monadic over

$\mathsf {Set}$

. We deliver an analogous result for the upper, lower, and convex Vietoris endofunctors acting on the category of stably compact spaces. We provide axiomatizations of the associated (infinitary) varieties. This can be seen as a version of Jónsson–Tarski duality for modal algebras beyond the zero-dimensional setting.
The impact of non-nutritive sweeteners on fertility, maternal and child health outcomes: a review of human and animal studies
Authors: Kearns Michelle L. , Reynolds Clare M.
Published: March 2024

There is significant evidence that an unhealthy diet greatly increases the risk of complications during pregnancy and predisposes offspring to metabolic dysfunction and obesity. While fat intake is typically associated with the onset of obesity and its comorbidities, there is increasing evidence linking sugar, particularly high fructose corn syrup, to the global rise in obesity rates. Furthermore, the detrimental effects of added sugar intake during pregnancy on mother and child have been clearly outlined. Guidelines advising pregnant women to avoid food and beverages with high fat and sugar have led to an increase in consumption of ‘diet’ or ‘light’ options. Examination of some human birth cohort studies shows that heavy consumption (at least one beverage a day) of non-nutritive sweetener (NNS) containing beverages has been associated with increased risk of preterm birth and increased weight/BMI in male offspring independent of maternal weight, which appears to be offset by breastfeeding for 6 months. Rodent models have shown that NNS exposure during pregnancy can impact maternal metabolic health, adipose tissue function, gut microbiome profiles and taste preference. However, the mechanisms underlying these effects are multifaceted and further research, particularly in a translational setting is required to fully understand the effects of NNS on maternal and infant health during pregnancy. Therefore, this review examines maternal sweetener intakes and their influence on fertility, maternal health outcomes and offspring outcomes in human cohort studies and rodent models.
Morphology, genetic characterization and phylogeny of Moniliformis tupaia n. sp. (Acanthocephala: Moniliformidae) from the northern tree shrew Tupaia belangeri chinensis Anderson (Mammalia: Scandentia)
Authors: Chen Hui-Xia , Yu Zhi-Jun , Ma Jun , Zhao Cui-Hong , Cao Fu-Qiong , Li Liang
Published: March 2024

A new species of Moniliformis, M. tupaia n. sp. is described using integrated morphological methods (light and scanning electron microscopy) and molecular techniques (sequencing and analysing the nuclear 18S, ITS, 28S regions and mitochondrial cox1 and cox2 genes), based on specimens collected from the intestine of the northern tree shrew Tupaia belangeri chinensis Anderson (Scandentia: Tupaiidae) in China. Phylogenetic analyses show that M. tupaia n. sp. is a sister to M. moniliformis in the genus Moniliformis, and also challenge the systematic status of Nephridiacanthus major. Moniliformis tupaia n. sp. represents the third Moniliformis species reported from China.
Emotion dynamics in current and remitted depression: an ecological momentary assessment study
Authors: Hawes Mariah T. , Klein Daniel N.
Published: March 2024

Background

Individuals in a depressive episode and healthy controls exhibit robust differences on affect dynamics captured with ecological momentary assessment (EMA). However, few studies have explored affect dynamics in individuals in remission from depression, and results have been mixed.

Methods

A community sample of 18-year-olds (N = 345) completed diagnostic interviews and EMA probing emotions and low interest/motivation 5× daily for 2 weeks. Affect home base, variability, and inertia were compared across currently depressed, remitted, and never-depressed groups.

Results

Both depression groups had a higher negative affect (NA) and low interest/motivation home base, lower positive affect (PA) home base, greater variability of NA, PA, and low interest/motivation, and greater NA and low interest/motivation inertia than never-depressed participants. Additionally, the currently depressed group had a higher sad home base specifically, greater variability across most negative emotions and low interest/motivation, and greater low interest/motivation inertia than the remitted group. The currently depressed and remitted groups did not differ in anxious, upset, or PA home base, anxious or PA variability, and inertia of all negative emotions and PA.

Conclusions

Findings suggest that a number of abnormalities in emotion and reward functioning persist after a depressive episode resolves, however, the tendency to experience higher levels of sadness, greater range of a variety of negative emotions, and more variable and persistent low interest/motivation are exacerbated during depressive episodes. Conversely, greater intensity and persistence of some negative emotions (anxiety, upset) and blunted positive emotions appear to equally characterize depression in both the symptomatic and remitted state.
Insomnia and parasomnia induced by validated smoking cessation pharmacotherapies and electronic cigarettes: a network meta-analysis
Authors: Vanderkam Paul , Pomes Charlotte , Dzeraviashka Palina , Castera Philippe , Jaafari Nematollah , Lafay-Chebassier Claire
Published: March 2024

We aim to assess the relationship between validated smoking cessation pharmacotherapies and electronic cigarettes (e-cigarettes) and insomnia and parasomnia using a systematic review and a network meta-analysis. A systematic search was performed until August 2022 in the following databases: PUBMED, COCHRANE, CLINICALTRIAL. Randomized controlled studies against placebo or validated therapeutic smoking cessation methods and e-cigarettes in adult smokers without unstable or psychiatric comorbidity were included. The primary outcome was the presence of “insomnia” and “parasomnia.” A total of 1261 studies were selected. Thirty-seven studies were included in the quantitative analysis (34 for insomnia and 23 for parasomnia). The reported interventions were varenicline (23 studies), nicotine replacement therapy (NRT, 10 studies), bupropion (15 studies). No studies on e-cigarettes were included. Bayesian analyses found that insomnia and parasomnia are more frequent with smoking cessation therapies than placebo except for bupropion. Insomnia was less frequent with nicotine substitutes but more frequent with bupropion than the over pharmacotherapies. Parasomnia are less frequent with bupropion but more frequent with varenicline than the over pharmacotherapies. Validated smoking cessation pharmacotherapies can induce sleep disturbances with different degrees of frequency. Our network meta-analysis shows a more favorable profile of nicotine substitutes for insomnia and bupropion for parasomnia. It seems essential to systematize the assessment of sleep disturbances in the initiation of smoking cessation treatment. This could help professionals to personalize the choice of treatment according to sleep parameters of each patient. Considering co-addictions, broadening the populations studied and standardizing the measurement are additional avenues for future research.
Astrobiological applications of μ-mapping X-ray fluorescence spectrometry
Authors: Blake David Frederick , Walroth Richard C. , Bristow Thomas F. , Sarrazin Philippe , Gailhanou Marc , Thompson Kathleen , Downs Robert Terrance , Yen Albert Shi-Yuen , Marchis Franck , Webb Samuel , Chalumeau Clement , Solé Vincente Armando , Walter Philippe , Chen Jianxin , Henderson Roger , Lafuente Barbara
Published: March 2024

In situ elemental imaging of planetary surface regolith at a spatial resolution of 100s to 1000s of microns can provide evidence of the provenance of rocks or sediments and their habitability, and can identify post-depositional diagenetic alteration affecting preservation. We use high-resolution elemental maps and XRF spectra from MapX, a flight prototype in situ X-ray imaging instrument, to demonstrate this technology in rock types relevant to astrobiology. Examples are given for various petrologies and depositional/diagenetic environments, including ultramafic/mafic rocks, serpentinites, hydrothermal carbonates, evaporites, stromatolitic cherts and diagenetic concretions.
Probing the Structure of SDSS J1004+4112 through Microlensing Analysis of Spectroscopic Data
Authors: Fian C. , Muñoz J. A. , Forés-Toribio R. , Mediavilla E. , Jiménez-Vicente J. , Chelouche D. , Kaspi S. , Richards G. T.
Published: March 2024

We aim to uncover the structure of the continuum and broad emission line (BEL) emitting regions in the gravitationally lensed quasar SDSS J1004+4112 through unique microlensing signatures. Analyzing 20 spectroscopic observations from 2003 to 2018, we study the striking deformations of various BEL profiles and determine the sizes of their respective emitting regions. We use the emission line cores as a baseline for no microlensing and then apply Bayesian methods to derive the sizes of the Lyα, Si IV, C IV, C III], and Mg II emitting regions, as well as of the underlying continuum-emitting sources. We find that the sizes of the emitting regions for the BELs are a few light-days across, notably smaller than in typical lensed quasars. The asymmetric distortions observed in the BELs suggest that the broad-line region lacks spherical symmetry and is likely confined to a plane. The inferred continuum emitting region sizes are larger than predictions based on standard thin-disk theory by a factor of ∼ 4. We find that the size-wavelength relation is in agreement with that of a geometrically thin and optically thick accretion disk.
Stellar mass fraction and quasar accretion disk size in SDSS J1004+4112 from photometric follow-up
Authors: Forés-Toribio R. , Muñoz J. A. , Fian C. , Jiménez-Vicente J. , Mediavilla E.
Published: March 2024

The gravitational lens SDSS J1004+4112 was the first discovered system where a background quasar is lensed by a galaxy cluster instead of a single galaxy. We use the 14.5-year r-band light curves together with the recently measured time delay of the fourth brightest quasar image (Munõz et al. (2022)) and the mass model from Forés-Toribio et al. (2022) to study the microlensing effect in this system. We constrain the quasar accretion disk size to light-days at 2407Å in the restframe which is compatible with most previous estimates. We also infer the fraction of mass in stars at the positions of the quasar images: $${\alpha _A} = 0.058_{ - 0.032}^{ + 0.024},{\alpha _B} = 0.048_{ - 0.014}^{ + 0.032},{\alpha _C} = 0.018_{ - 0.018}^{ + 0.015}$$ and
$${\alpha _D} = 0.008_{ - 0.008}^{ + 0.033}$$
. The stellar fraction estimates are reasonable for intracluster medium although the stellar fractions at images A and B are slightly larger, suggesting the presence of a near undetected galaxy.
The “External” Shears In Strong Lens Models
Authors: Nightingale James W. , Etherington Amy , Massey Richard
Published: March 2024

The distribution of mass in galaxy-scale strong gravitational lenses is often modelled as an elliptical power law plus ‘external shear’, which notionally accounts for line-of-sight galaxies and cosmic shear. We argue that it does not, using three lines of evidence from the analysis of 54 galaxy-scale strong lenses: (i) strong lensing external shears do not correlate with weak lensing; (ii) the measured shear magnitudes in strong lenses (which are field galaxies) are too large (exceeding 0.05) for their environment and; (iii) the external shear position angle preferentially aligns or anti-aligns with the mass model position angle, indicating an internal origin. We argue the measured strong lensing shears are therefore systematically accounting for missing complexity in the canonical elliptical power-law mass model. If we can introduce this complexity into our lens models, this will further lensing studies of galaxy formation, dark matter and Cosmology.
The present & future of lensed supernovae: from ZTF to LSST
Authors: Arendse Nikki
Published: March 2024

Gravitationally lensed supernovae (SNe) are rare and valuable probes of astrophysics and cosmology. While only seven lensed SNe have currently been discovered, these numbers are predicted to increase by orders of magnitudes with future transient surveys such as the Legacy Survey of Space and Time (LSST). These proceedings describe the ongoing live search with the Zwicky Transient Facility (ZTF), including the discovery of SN ‘Zwicky’: a lensed SN found in a remarkably low-mass lens galaxy. Finally, we look ahead at predictions for detecting lensed SNe with LSST.
Combined strong and weak gravitational lensing mass measurements in clusters of galaxies
Authors: Abriola Davide
Published: March 2024

Gravitational lensing in clusters of galaxies is one of the most powerful methods to probe the dark matter mass distribution inside such systems, after mapping the baryonic component, and test the currently accepted ɅCDM cosmological paradigm. With the advent of new high-resolution facilities such as the JWST, strong lensing (SL) is capable of providing extremely accurate mass measurements in the densest regions of such structures. Weak lensing (WL) provides complementary information by measuring the total mass distribution in the outskirts of galaxy clusters, where no multiple images of background sources are produced.

In my talk, I will present updates on the WL mass reconstruction of the Frontier Fields galaxy cluster Abell 2744 (z = 0.308) based on Subaru, Magellan, and JWST data, and I will show how the results obtained, combined with accurate SL modeling of this lens, provide a consistent picture of the cluster total mass distribution. I will discuss the pipeline used for this work, the extensive checks performed on the different datasets and the scientific results obtained. Being composed of several substructures undergoing a merging process, the complex geometry of this cluster makes it an ideal laboratory to verify the consistency and reliability of the results obtained with the two methods. I will compare the predictions of the SL models extrapolated in the outer regions of the cluster with the non-parametric WL mass reconstruction to look for potential systematic effects affecting the SL analysis.
Joint lensing–dynamics constraint on the elliptical galaxy mass profile from the largest galaxy–galaxy lens sample
Authors: Tan Chin Yi , Shajib Anowar
Published: March 2024

From various lensing and non-lensing observations, the total density profile in elliptical galaxies is well approximated by a power law mass distribution. However, as neither the dark matter nor the baryons individually follow the power law, this observational result has been referred to as the “bulge–halo conspiracy”. We investigate the consistency of this conspiracy with higher precision than previous studies with the largest ever sample of galaxy–galaxy lenses assembled from archival Hubble Space Telescope (HST) data. By performing lens modelling with power law profiles and combining them with stellar dynamics using the mass-sheet transformation, we can constrain the profile’s deviation from the power law model over a redshift range of 0.1 to 0.8. To uniformly model such a large sample of lens models, we use the automated modelling pipeline dolphin. We also investigate the evolutionary trend of the total mass density slope of the lensing galaxies.
A Case Study on the Rainstorm‐Producing Mesoscale Vortices in Central‐Eastern China
Authors: Huang Ting‐Ting , Fu Shen‐Ming , Wang Zhen‐Guo , Zhao Shen , Sun Jian‐Hua , Zhang Yong , Wang Shao‐Hua
Published: March 2024

During 26–27 June 2022, mainly influenced by three mesoscale vortices, central‐eastern China (particularly for Henan and Shandong) experiences the first widespread torrential rainfall event of the 2022 flood season (maximum 24‐hr accumulated precipitation is ∼380.9 mm), resulting in severe social impacts. The three mesoscale vortices form and sustain under favorable background conditions, mainly including a strong upper‐level divergence, an intense middle‐level warm advection, and a powerful lower‐level convergence associated with a low‐level jet. Among the vortices, the vortex which forms over Shandong, lasts for ∼9 hr, and makes a much larger contribution than the other vortices to the accumulated precipitation, is defined as the primary vortex. More than a half of the hourly precipitation peaks in this event appear in the life span of the primary vortex, which is closely related to the variations of the vortex in its cyclonic‐vorticity and vertical extent. Backward trajectory analysis indicates that air particles originating from the lower troposphere southwest of the primary vortex contribute the most to its formation (∼82.7%). These air particles mainly experience a notable increase in their cyclonic‐vorticity due to convergence‐related vertical stretching, which directly renders the formation of primary vortex. During the whole life span of the primary vortex, convergence‐related vertical stretching is the most favorable factor for its development/sustainment, and the convection‐related vertical transport of cyclonic vorticity ranks second; whereas, the horizontal transport is the most detrimental factor. Moisture budget shows that Southeast China is the most important moisture source for this event (accounting for ∼48.9%).
Emergent Constraint on Projection of the North Pacific Monsoon Trough and Its Implications for Typhoon Activity Using CMIP6 Models
Authors: Gou Yan , Wang Chao , Wu Yuqin , Wu Liguang
Published: March 2024

The North Pacific monsoon trough (NPMT) is an imperative large‐scale circulation pattern influencing tropical cyclone (TC) activity in the western North Pacific (WNP), thus its future change has great implications for the WNP TC activity. Here future change in the NPMT and its uncertainty are examined by using 35 climate models from Phase six of Coupled Model Intercomparison Project (CMIP6). Due to the El Niño‐like sea surface temperature (SST) pattern, the multi‐model ensemble (MME) mean projects an eastward extension of the NPMT in the latter half of the 21st century. However, considerable inter‐model uncertainty exists in the projection, which is associated with the diversity in the zonal SST gradient across the tropical Pacific. This diversity in the projected SST is largely rooted in the simulated precipitation biases in the tropical Pacific in the historical experiments of CMIP6 models, which can modulate future Pacific SST distribution through the shortwave‐SST feedback. This linkage between biases in historical climate and future climate allows us to constrain the projection by using observational data sets. Emergent constraint using observational precipitation data set reduces the projection uncertainty by 48% and projects an eastward extension of the north Pacific NPMT by 6.2°. This eastward extension of the NPMT indicates an eastward migration of TC genesis location, and elongated TC track and thus strengthened TC intensity, suggesting an increased TC‐related disaster for residents near the WNP.
Allopurinol and blood pressure variability following ischemic stroke and transient ischemic attack: a secondary analysis of XILO-FIST
Authors: MACDONALD Alexander S. , MCCONNACHIE Alex , DICKIE David Alexander , BATH Philip M. , FORBES Kirsten , QUINN Terence , BROOMFIELD Niall M. , DANI Krishna , DONEY Alex , MUIR Keith W. , STRUTHERS Allan , WALTERS Matthew , BARBER Mark , BHALLA Ajay , CAMERON Alan , GUYLER Paul , HASSAN Ahamad , KEARNEY Mark , KEEGAN Breffni , LAKSHMANAN Sekaran , MACLEOD Mary Joan , RANDALL Marc , SHAW Louise , SUBRAMANIAN Ganesh , WERRING David , DAWSON Jesse
Published: March 2024

Blood Pressure Variability (BPV) is associated with cardiovascular risk and serum uric acid level. We investigated whether BPV was lowered by allopurinol and whether it was related to neuroimaging markers of cerebral small vessel disease (CSVD) and cognition. We used data from a randomised, double-blind, placebo-controlled trial of two years allopurinol treatment after recent ischemic stroke or transient ischemic attack. Visit-to-visit BPV was assessed using brachial blood pressure (BP) recordings. Short-term BPV was assessed using ambulatory BP monitoring (ABPM) performed at 4 weeks and 2 years. Brain MRI was performed at baseline and 2 years. BPV measures were compared between the allopurinol and placebo groups, and with CSVD and cognition. 409 participants (205 allopurinol; 204 placebo) were included in the visit-to-visit BPV analyses. There were no significant differences found between placebo and allopurinol groups for any measure of visit-to-visit BPV. 196 participants were included in analyses of short-term BPV at week 4. Two measures were reduced by allopurinol: the standard deviation (SD) of systolic BP (by 1.30 mmHg (95% confidence interval (CI) 0.18–2.42, p = 0.023)); and the average real variability (ARV) of systolic BP (by 1.31 mmHg (95% CI 0.31–2.32, p = 0.011)). There were no differences in other measures at week 4 or in any measure at 2 years, and BPV was not associated with CSVD or cognition. Allopurinol treatment did not affect visit-to-visit BPV in people with recent ischemic stroke or TIA. Two BPV measures were reduced at week 4 by allopurinol but not at 2 years.
Gender and geographic diversity of global oral health organisations
Authors: Lalloo Ratilal
Published: March 2024

Introduction Diversity of leadership of global oral health organisations is critical to ensure a global agenda.

Aim To analyse the gender and geographic diversity of global oral health organisations.

Methods Publicly available data on the gender of their staff and leadership, and congress locations, were analysed. Gender was allocated from photographs if available, and using Genderize, an online allocation platform. Location of leaders and global congresses were analysed by country, region and World Bank income category. The organisations analysed were the International Association of Dental Research (IADR), FDI World Dental Federation, International Federation of Dental Hygienists (IFDH) and 15 dental specialist global associations.

Results The majority of headquarter staff in the IADR (76%) and FDI (84%) are female. Gender diversity in the leadership differs across the various organisations, with recent progress towards gender parity. The IFDH was and is exclusively female-led. The majority of leaders are from high-income countries in Europe and North America. Of the 370 congress locations, 90% were held in high-income countries.

Conclusion There is recent progress towards gender diversity in the leadership; however, this leadership is essentially from high-income countries. There is an urgent need to publicly commit to diversity goals and implement strategies to reflect the oral health workforce and be truly diverse and global.
CAR T therapies in multiple myeloma: unleashing the future
Authors: Sheykhhasan Mohsen , Ahmadieh-Yazdi Amirhossein , Vicidomini Rosario , Poondla Naresh , Tanzadehpanah Hamid , Dirbaziyan Ashkan , Mahaki Hanie , Manoochehri Hamed , Kalhor Naser , Dama Paola
Published: March 2024

In recent years, the field of cancer treatment has witnessed remarkable breakthroughs that have revolutionized the landscape of care for cancer patients. While traditional pillars such as surgery, chemotherapy, and radiation therapy have long been available, a cutting-edge therapeutic approach called CAR T-cell therapy has emerged as a game-changer in treating multiple myeloma (MM). This novel treatment method complements options like autologous stem cell transplants and immunomodulatory medications, such as proteasome inhibitors, by utilizing protein complexes or anti-CD38 antibodies with potent complement-dependent cytotoxic effects. Despite the challenges and obstacles associated with these treatments, the recent approval of the second FDA multiple myeloma CAR T-cell therapy has sparked immense promise in the field. Thus far, the results indicate its potential as a highly effective therapeutic solution. Moreover, ongoing preclinical and clinical trials are exploring the capabilities of CAR T-cells in targeting specific antigens on myeloma cells, offering hope for patients with relapsed/refractory MM (RRMM). These advancements have shown the potential for CAR T cell-based medicines or combination therapies to elicit greater treatment responses and minimize side effects. In this context, it is crucial to delve into the history and functions of CAR T-cells while acknowledging their limitations. We can strategize and develop innovative approaches to overcome these barriers by understanding their challenges. This article aims to provide insights into the application of CAR T-cells in treating MM, shedding light on their potential, limitations, and strategies employed to enhance their efficacy.
Effect of bias potential and dimension on electrochemical migration of capacitors for implantable devices
Authors: Du Shiyao , Li Feng , Grumsen Flemming Bjerg , Ambat Rajan , Tang Ao , Li Ying
Published: March 2024

Dendrite formation induced by electrochemical migration (ECM) is a common reliability problem occurring on printed circuit boards (PCBs), which significantly threatens the long-term safe operations of current implantable electronic devices (IEDs). Although several factors (i.e., contaminations, humidity, temperature) are proved to be the parameters closely related to ECM susceptibility of capacitors on a PCB under climate environments, further targeted research under other environments still needs to be conducted as ECM is highly environmental-dependent. Herein, the effects of bias potential and pitch dimension on ECM sensitivity are systematically studied using various sizes of capacitors on a test PCB under a human implantation environment. The finite element method first proves that a DC voltage pattern could be regarded as an accelerated test compared to other waveforms. Subsequent chronoamperometry tests using the DC potential further indicate that dendrite formation is closely related to pitch dimension under low bias potential, while under high bias potential electric field is also the dominating factor of dendrite formation for capacitors on a PCB. Benefiting from the electrochemical impedance spectroscopy (EIS) technique, the capacitor reliability under different corrosion states is also evaluated in a detailed manner. This work offers great value both in electronic corrosion mechanisms and future rational design for reliable IEDs.
Commonality and variation in mental representations of music revealed by a cross-cultural comparison of rhythm priors in 15 countries
Authors: Jacoby Nori , Polak Rainer , Grahn Jessica A. , Cameron Daniel J. , Lee Kyung Myun , Godoy Ricardo , Undurraga Eduardo A. , Huanca Tomás , Thalwitzer Timon , Doumbia Noumouké , Goldberg Daniel , Margulis Elizabeth H. , Wong Patrick C. M. , Jure Luis , Rocamora Martín , Fujii Shinya , Savage Patrick E. , Ajimi Jun , Konno Rei , Oishi Sho , Jakubowski Kelly , Holzapfel Andre , Mungan Esra , Kaya Ece , Rao Preeti , Rohit Mattur A. , Alladi Suvarna , Tarr Bronwyn , Anglada-Tort Manuel , Harrison Peter M. C. , McPherson Malinda J. , Dolan Sophie , Durango Alex , McDermott Josh H.
Published: March 2024

Music is present in every known society but varies from place to place. What, if anything, is universal to music cognition? We measured a signature of mental representations of rhythm in 39 participant groups in 15 countries, spanning urban societies and Indigenous populations. Listeners reproduced random ‘seed’ rhythms; their reproductions were fed back as the stimulus (as in the game of ‘telephone’), such that their biases (the prior) could be estimated from the distribution of reproductions. Every tested group showed a sparse prior with peaks at integer-ratio rhythms. However, the importance of different integer ratios varied across groups, often reflecting local musical practices. Our results suggest a common feature of music cognition: discrete rhythm ‘categories’ at small-integer ratios. These discrete representations plausibly stabilize musical systems in the face of cultural transmission but interact with culture-specific traditions to yield the diversity that is evident when mental representations are probed across many cultures.
Diverse plasmid systems and their ecology across human gut metagenomes revealed by PlasX and MobMess
Authors: Yu Michael K. , Fogarty Emily C. , Eren A. Murat
Published: March 2024

Plasmids alter microbial evolution and lifestyles by mobilizing genes that often confer fitness in changing environments across clades. Yet our ecological and evolutionary understanding of naturally occurring plasmids is far from complete. Here we developed a machine-learning model, PlasX, which identified 68,350 non-redundant plasmids across human gut metagenomes and organized them into 1,169 evolutionarily cohesive ‘plasmid systems’ using our sequence containment-aware network-partitioning algorithm, MobMess. Individual plasmids were often country specific, yet most plasmid systems spanned across geographically distinct human populations. Cargo genes in plasmid systems included well-known determinants of fitness, such as antibiotic resistance, but also many others including enzymes involved in the biosynthesis of essential nutrients and modification of transfer RNAs, revealing a wide repertoire of likely fitness determinants in complex environments. Our study introduces computational tools to recognize and organize plasmids, and uncovers the ecological and evolutionary patterns of diverse plasmids in naturally occurring habitats through plasmid systems.
The interplay of semantic and syntactic processing across hemispheres
Authors: Kim Sangyub , Nam Kichun , Lee Eun-Ha
Published: March 2024

The current study investigated the hemispheric dynamics underlying semantic and syntactic priming in lexical decision tasks. Utilizing primed-lateralized paradigms, we observed a distinct pattern of semantic priming contingent on the priming hemisphere. The right hemisphere (RH) exhibited robust semantic priming irrespective of syntactic congruency between prime and target, underscoring its proclivity for semantic processing. Conversely, the left hemisphere (LH) demonstrated slower response times for semantically congruent yet syntactically incongruent word pairs, highlighting its syntactic processing specialization. Additionally, nonword data revealed a hemispheric divergence in syntactic processing, with the LH showing significant intrahemispheric syntactic priming. These findings illuminate the intrinsic hemispheric specializations for semantic and syntactic processing, offering empirical support for serial processing models. The study advances our understanding of the complex interplay between semantic and syntactic factors in hemispheric interactions.
Structural variants in the Epb41l4a locus: TAD disruption and Nrep gene misregulation as hypothetical drivers of neurodevelopmental outcomes
Authors: Salnikov Paul , Korablev Alexey , Serova Irina , Belokopytova Polina , Yan Aleksandra , Stepanchuk Yana , Tikhomirov Savelii , Fishman Veniamin
Published: March 2024

Structural variations are a pervasive feature of human genomes, and there is growing recognition of their role in disease development through their impact on spatial chromatin architecture. This understanding has led us to investigate the clinical significance of CNVs in noncoding regions that influence TAD structures. In this study, we focused on the Epb41l4a locus, which contains a highly conserved TAD boundary present in both human chromosome 5 and mouse chromosome 18, and its association with neurodevelopmental phenotypes. Analysis of human data from the DECIPHER database indicates that CNVs within this locus, including both deletions and duplications, are often observed alongside neurological abnormalities, such as dyslexia and intellectual disability, although there is not enough evidence of a direct correlation or causative relationship. To investigate these possible associations, we generated mouse models with deletion and inversion mutations at this locus and carried out RNA-seq analysis to elucidate gene expression changes. We found that modifications in the Epb41l4a TAD boundary led to dysregulation of the Nrep gene, which plays a crucial role in nervous system development. These findings underscore the potential pathogenicity of these CNVs and highlight the crucial role of spatial genome architecture in gene expression regulation.
Studying the impact of marital status on diagnosis and survival prediction in pancreatic ductal carcinoma using machine learning methods
Authors: Chen Qingquan , Hu Yiming , Lin Wen , Huang Zhimin , Li Jiaxin , Lu Haibin , Dai Rongrong , You Liuxia
Published: March 2024

Pancreatic cancer is a commonly occurring malignant tumor, with pancreatic ductal carcinoma (PDAC) accounting for approximately 95% of cases. According of its poor prognosis, identifying prognostic factors of pancreatic ductal carcinoma can provide physicians with a reliable theoretical foundation when predicting patient survival. This study aimed to analyze the impact of marital status on survival outcomes of PDAC patients using propensity score matching and machine learning. The goal was to develop a prognosis prediction model specific to married patients with PDAC. We extracted a total of 206,968 patient records of pancreatic cancer from the SEER database. To ensure the baseline characteristics of married and unmarried individuals were balanced, we used a 1:1 propensity matching score. We then conducted Kaplan–Meier analysis and Cox proportional-hazards regression to examine the impact of marital status on PDAC survival before and after matching. Additionally, we developed machine learning models to predict 5-year CSS and OS for married patients with PDAC specifically. In total, 24,044 PDAC patients were included in this study. After 1:1 propensity matching, 8043 married patients and 8,043 unmarried patients were successfully enrolled. Multivariate analysis and the Kaplan–Meier curves demonstrated that unmarried individuals had a poorer survival rate than their married counterparts. Among the algorithms tested, the random forest performed the best, with 0.734 5-year CSS and 0.795 5-year OS AUC. This study found a significant association between marital status and survival in PDAC patients. Married patients had the best prognosis, while widowed patients had the worst. The random forest is a reliable model for predicting survival in married patients with PDAC.
Prevalence and risk factors of oral potentially malignant disorders in Indonesia: a cross-sectional study undertaken in 5 provinces
Authors: Sari Elizabeth Fitriana , Johnson Newell W. , McCullough Michael John , Cirillo Nicola
Published: March 2024

Detection of subjects with oral potentially malignant disorders in a population is key to early detection of oral cancer (OC) with consequent reduction of cancer-related morbidity and mortality. Our aim was to investigate the prevalence and associated risk factors for OPMD in representative provinces of Indonesia. This cross-sectional study was undertaken in five Indonesian provinces: West Java (WJ), Jakarta (JKT), West Papua (WP), West Kalimantan (WK) and Banda Aceh (BA). Respondents answered a previously validated questionnaire including information on ethnicity, occupation, socioeconomic status (SES), oral health practices, and behaviours associated with oral cancer. An oral examination was undertaken using WHO standardized methodology. Data were analysed using ANOVA, Chi-Square, and logistic regression to assess association between risk factors and mucosal disease. A total of 973 respondents between the ages of 17 and 82 years was enrolled (WJ 35.5%,JKT 13.3% WP 18.3%, WK 9%, BA 23.9%). Tobacco smoking (14.8%), Betel quid (BQ) chewing (12.6%) and alcohol drinking (4%) varied geographically. A well-established OPMD was detected in 137 (14.1%) respondents and 2 (0.2%) presented with chronic ulceration later diagnosed as OC. Leukoplakia was the most common OPMD found (9.7%), while the prevalence of oral submucous fibrosis (OSMF), not previously described in the nation, was 2.3%. Poor knowledge of OC risk factors, poor oral hygiene behaviours, low-income SES and ethnicity were significantly associated with the presence of an OPMD. There is a previously under-reported high prevalence of OPMD in Indonesia. Overall, we found a strong correlation between the presence of an OPMD and individual habituation to known risk factors.
Recent tobacco smoking, restaurant and in-car secondhand smoke exposure are associated with depressive symptoms among young adults: a population-based cross-sectional analysis
Authors: Mo Hongfei , Wang Changhong , Li Yan
Published: March 2024

The purpose of this study was to evaluate the association between recent tobacco smoking, household secondhand smoke exposure, confined space secondhand smoke exposure and depressive symptoms in young adults after adjustments for each other. Data from NHANES 2013–2018 were extracted. A total of 4129 young adults age 18–35 years (mean age 26.11 ± 5.39 years, 2021 males and 2108 females) were included. Depressive symptoms were screened by PHQ-9. Recent tobacco smoking was assessed through question “smoked tobacco in the last 5 days?”. Household secondhand smoke exposure was assessed through question “living with a smoker who smoked inside the house?”. Confined space secondhand smoke exposure was assessed by SSEQ. Binary logistic regression models were performed to analyze the associations. Significant association were observed in recent tobacco smoking (OR = 1.593, 95% CI 1.318–1.926) and confined space secondhand smoke exposure (OR = 1.399, 95% CI 1.185–1.651), but not in household secondhand smoke exposure (P = 0.108). Among the different settings of confined space secondhand smoke exposure, restaurant (OR = 1.732, 95% CI 1.120–2.678) and in-car (OR = 1.350, 95% CI 1.102–1.652) exposure were significantly associated with depressive symptom after after fully adjustments.
Critical evaluation of artificial intelligence as a digital twin of pathologists for prostate cancer pathology
Authors: Eminaga Okyaz , Abbas Mahmoud , Kunder Christian , Tolkach Yuri , Han Ryan , Brooks James D. , Nolley Rosalie , Semjonow Axel , Boegemann Martin , West Robert , Long Jin , Fan Richard E. , Bettendorf Olaf
Published: March 2024

Prostate cancer pathology plays a crucial role in clinical management but is time-consuming. Artificial intelligence (AI) shows promise in detecting prostate cancer and grading patterns. We tested an AI-based digital twin of a pathologist, vPatho, on 2603 histological images of prostate tissue stained with hematoxylin and eosin. We analyzed various factors influencing tumor grade discordance between the vPatho system and six human pathologists. Our results demonstrated that vPatho achieved comparable performance in prostate cancer detection and tumor volume estimation, as reported in the literature. The concordance levels between vPatho and human pathologists were examined. Notably, moderate to substantial agreement was observed in identifying complementary histological features such as ductal, cribriform, nerve, blood vessel, and lymphocyte infiltration. However, concordance in tumor grading decreased when applied to prostatectomy specimens (κ = 0.44) compared to biopsy cores (κ = 0.70). Adjusting the decision threshold for the secondary Gleason pattern from 5 to 10% improved the concordance level between pathologists and vPatho for tumor grading on prostatectomy specimens (κ from 0.44 to 0.64). Potential causes of grade discordance included the vertical extent of tumors toward the prostate boundary and the proportions of slides with prostate cancer. Gleason pattern 4 was particularly associated with this population. Notably, the grade according to vPatho was not specific to any of the six pathologists involved in routine clinical grading. In conclusion, our study highlights the potential utility of AI in developing a digital twin for a pathologist. This approach can help uncover limitations in AI adoption and the practical application of the current grading system for prostate cancer pathology.
circRNA_SLC8A1 promotes the survival of mycobacterium tuberculosis in macrophages by upregulating expression of autophagy-related protein SQSTM1/p62 to activate the NF-κB pathway
Authors: Li Zhenyun , Gao Yuan , Zhang Bianfang , Dong Wei , Xi Yuling , Li Yan , Cui Junwei
Published: March 2024

Macrophages act as the first immune defense line of the host against Mycobacterium tuberculosis (Mtb). A previous study showed that circRNA_SLC8A1 was significantly upregulated in Mtb-infected macrophages, but its regulatory mechanism in anti-tuberculosis infection is unclear. Therefore, this study aimed to investigate the role of circRNA_SLC8A1 in the anti-tuberculosis activity of macrophages. We showed that circRNA_SLC8A1 was upregulated in tuberculosis patients. Moreover, the binding sites of miR-20b-5p on circRNA_SLC8A1 and Sequestosome 1 (SQSTM1/p62) mRNA were predicted by StarBase and verified by the double luciferase reporter gene assay. Next, we found that miR-20b-5p expression was decreased, while SQSTM1 protein expression was increased in a time- and dose-dependent manner in the human macrophage U937 in response to Mtb infection. Furthermore, circRNA_SLC8A1 overexpression vector (circRNA_SLC8A1) or shRNA (sh-circRNA_SLC8A1) and/or miR-20b-5p mimic or inhibitor and/or SQSTM1 overexpression vector (SQSTM1) or small interfering RNA (si-SQSTM1) or its corresponding control were transfected into Mtb-infected macrophages. Results showed that overexpression of circRNA_SLC8A1 or miR-20b-5p inhibitor promoted the secretion of pro-inflammatory factors IL-1β, IL-6, and TNF-α, increased Nitric Oxide (NO) content and inducible nitric oxide synthase (iNOS) expression, inhibited Reactive oxygen species (ROS) production. Cleaved-caspase-3 protein expression, and cell apoptosis, and promoted Mtb survival. Silencing SQSTM1 inhibited secretion of pro-inflammatory factors and activation of the NF-κB pathway. Overexpression of miR‐20b‐5p blocked the promoting of circ‐SLC8A1 on SQSTM1 protein expression. In summary, circRNA_SLC8A1 sponged miR‐20b‐5p to upregulate SQSTM1/p62 expression and promoted Mtb survival in macrophages through the NF-κB signaling pathway.