bluuebunny/crossref_metadata_2025 huggingface dataset:
Registered nurse verification of expected adult death: new guidance provides direction
Authors: Laverty Diane , Wilson Jo , Cooper Marie
Published: April 2018

Despite UK national guidance on care after death, it is clear that the bereaved family can experience distress while waiting for the patient's death to be verified. This distress can escalate if there is a delay in verification. Anecdotally, such delays particularly occur out of hours and in community settings. Verification of death is a clinical task and an act of care whereby the identity of the person and death is confirmed. In addition, the subsequent providers of care to the deceased, such as families, mortuary teams, funeral directors and cremation services, have their health and safety protected by the provision of pertinent patient-specific information, for instance, infection risk and implantable devices, within the bounds of confidentiality. During this time, the bereaved family may also receive emotional support and information from the skilled clinician. Registered Nurse Verification of Expected Adult Death (RNVoEAD) guidance and associated competencies have recently been developed to ensure that the registered nurses involved in the patient's care can feel confident about their responsibilities and competent in the process of verifying death. It is hoped that this guidance will help to avoid delays that may cause additional distress to grieving families. This article sets out the rationale for the guidance, as well as discussing outstanding concerns and proposals for future considerations
Family members' experiences of care of the dying in residential care homes where the Liverpool Care Pathway was used
Authors: Andersson Sofia , Lindqvist Olav , Fürst Carl-Johan , Brännström Margareta
Published: April 2018

Background:

Residential care homes (RCHs) are increasingly becoming a common place of death for older people.

Aim:

The aim of this study was to describe family members' experiences of care of the dying in RCHs where the Liverpool care pathway for the dying patient was used.

Methods:

This study had a descriptive qualitative study design. Fifteen (n=15) individual interviews were analysed using qualitative content analysis.

Results:

The analysis resulted in three themes: being confident in a familiar and warm atmosphere, being involved vs not being involved in end-of-life (EoL) care, and being consoled by witnessing the health professional's endeavour to relieve suffering.

Significance of results:

The results indicated that taking part in a care plan seems to increase family members' feelings of involvement in EoL care. This study also highlights the family members' needs for increased possibilities for EoL discussions with the GP.
All about…: intergenerational co-location
Authors: George Lorraine
Published: April 2018

Intergenerational co-location is the way forward in developing early years practice to meet the needs of young children and the elderly today. Lorraine George explains why
Access for all
Authors: Russell Meredith Jones
Published: April 2018

A literacy campaign in Birmingham is reaching out to isolated families and improving the skills of parents so they can also help their children's development, finds Meredith Jones Russell
Tooled up!
Authors: Moorhouse Pete
Published: April 2018

Woodwork is a highly engaging activity for young children that encourages persistence and self-esteem, writes Pete Moorhouse
Express delivery
Authors: Pound Linda
Published: April 2018

In the final part of her series, Linda Pound explores the role of music in Expressive Arts and Design
Five ways to develop…: upper-body strength
Authors: Mountain Julie
Published: April 2018

Julie Mountain provides some tips for helping children develop the muscles in their upper body
With every sip
Authors: Vollans Caroline
Published: April 2018

With little awareness of Foetal Alcohol Spectrum Disorders and growing concern about their prevalence, practitioners need to know how to cater for children affected, finds Caroline Vollans
Perceptions of prospective Turkish Teachers regarding Literature Circles
Authors: Aytan Talat
Published: April 2018

The fact that the prospective Turkish teachers’ having a command of different methods and techniques as being Turkish teachers of the future is important in terms of its positive effects on the comprehension and expression skills of the middle school students. This study used the case study design and the qualitative approach. The aim of the research was to test the effectiveness of literature circle method and contribute to the field in theoretical and practical context. Fourty-six prospective Turkish teachers were conveniently sampled from the state university in Istanbul, to participate in the study. During six weeks, the opinions of prospective Turkish teachers who applied literature circle method were collected through unstructured interview forms. The data collected were subjected to a content analysis. It was concluded that prospective Turkish teachers found the method of literature circle favorible, in terms of cooperation, solidarity, gaining different perspectives, revealing hidden talents, developing self-confidence, aesthetic pleasure, enriching vocabulary and catching the details.
Current trends in primary school education: Studies published in the journals of faculties of educational sciences carried out in the field of primary-school teacher
Authors: Anılan Hüseyin , Anagün Şengül Saime , Anılan Burcu , Atalay Nurhan , Kılıç Zeynep
Published: April 2018

The purpose of this study is to examine the trends of studies about primary-school teaching published in the journals of faculties of educational sciences. Within the scope of this general purpose, answers were sought for the questions below: What is the distribution of the studies published in journals of faculties of educational sciences in terms of; the subject of the study, the population and the study group, data collection tools and data analysis techniques. The criteria determined for this study are that the articles should be published in the journals of the faculties of educational studies accepted to the ULAKBIM database between 2010 and 2016 and should be open-access and related to primary-school teaching. When these criteria were considered, a total of 21 journals and 311 articles published between 2010 and 2016 were accessed. Document analysis method was utilized for collecting the data. Descriptive analysis technique was used to analyze the collected data. It has been observed that the most dealt subject in the articles are evaluation, thinking abilities, self-efficacy, first-reading and writing, and affective traits.
The effect of the correction of self-assessment-based chance success on psychometric characteristics of the test
Authors: Özdoğan Didem , Doğan Nuri
Published: April 2018

This study examines the effect of self-assessment-based chance success on psychometric characteristics of the test. First, the data was cleared of chance success by means of correction-for-guessing formula and self-assessment, and then statistical analyses were conducted. Item discriminations showed an increase when the correction-for-guessing formula was used; and when self-assessment was used, they showed variability. Test validity increased when correction formula was used; and when self-assessment was used, a slight decrease was observed. Besides, this study examined the effect of correction for chance success upon corrected self-assessment based on IRT guessing parameter. It was observed that the data that were not corrected in accordance with chance scores had higher guessing parameters than those corrected in accordance with self-assessment. In addition, it was evident that the difference between the guessing parameters of the uncorrected data and the data cleared of chance scores by means of self-assessment was significant. It was also revealed that the correction of self-assessment-based chance success have an advantage over classical correction for guessing formula on psychometric characteristics of the test.
Instante y situación. Problematización de la relación entre instante y situación en torno a Ser y tiempo de Martin Heidegger
Authors: Garrido Maturano Ángel Enrique
Published: April 2018

El artículo problematiza el concepto de instante en la obra temprana de M. Heidegger, particularmente Ser y tiempo. La problematización  se propone, en primer lugar, mostrar en qué medida no es el instante como mirada quien abre la situación, sino la situación, como espacio de concernencia, quien posibilita el instante. En segundo, elucida el instante como un fenómeno responsivo y lo vincula a un acontecimiento repentino, decisivo y alterador que configura la situación a la que responde. En tercero, muestra cómo el instante repercute en la eclosión de la situación. Finalmente, determina el carácter esencialmente espacio-temporal del fenómeno.
La ética diferencial de Rosi Braidotti
Authors: Arribas Brais Gonzalez
Published: April 2018

En este artículo se analiza la ética de la diferencia elaborada por Rosi Braidotti, así como la concepción de la subjetividad nómade y posthumana que la sostiene. La propuesta de Braidotti, que se define por una decidida apuesta por la positividad y la inmanencia, nos permite articular una alternativa consistente y viable a la ética liberal e individualista, que tiene su raíz en el humanismo tradicional, intentando asimismo reparar los peores peligros que la afectan: la legitimación y reproducción de una violencia que impide y bloquea el desenvolvimiento de la alteridad que no se adecúa a la idea de ser humano dominante.
Anti-fibrotic effects of polygonum plebeium r.br. in CCl4-induced hepatic damage and fibrosis in rats
Authors: Rehman Atta Ur , Waheed Ayisha , Tariq Rabia , Zaman Muhammad , Javaid Tahir Muhammad
Published: April 2018

Introduction: Asian countries have the highest burden of liver diseases. Polygonum plebeium (P. plebeium), a.k.a. the common knotweed, is a species of plant in the knotwood family that can act as a blood purifier and has been widely used in Pakistan to cure liver disorders like jaundice and hepatitis. The plant is also used in the treatment of pneumonia, bowel complaints, diarrhea, dysentery, eczema and ring worms. Tannins, flavonoids, saponins and alkaloids are the major components of P. plebeium. Since its use in folk medicine in Pakistan, there has been little scientific evidence or information on it. Therefore, this study was aimed at investigating the anti-fibrotic effects of P. plebeium in carbon tetrachloride (CCl4)-induced hepatic toxicity and fibrosis.
Methods: The extracts of whole plant of P. plebeium were prepared and administered by oral gavage in rats. Liver fibrosis was induced by intraperitoneal (i.p.) administration of CCl4. To evaluate the hepatoprotective activity of P. plebeium, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transpeptidase (γGT) levels were quantified. Histological evaluation of liver tissue revealed tissue necrosis and extracellular matrix deposition. Real-time PCR was done to evaluate mRNA expression of genes related to liver fibrosis.
Results: The groups treated with P. plebeium extract showed an ablation in liver damage; the elevated enzyme levels of ALT, AST and γGT were decreased. Treatment with P. plebeium extract treatment restored the CCl4-induced tissue fibrosis by significantly suppressing alpha-smooth muscle actin (α-SMA), tumor growth factor beta (TGF-β) and collagen mRNA expression levels. Histology of liver sections also showed that the CCl4-induced fibrosis was improved in the treatment groups.
Conclusion: Polygonum plebeium has therapeutic potential and can be used for preventing fibrosis in inflammatory liver disease.
HEART TRANSPLANTATION IN DIABETIC RECIPIENTS
Authors: Poptsov V. N. , Zolotova E. N.
Published: April 2018

Diabetes mellitus is one of the most prevalent chronic metabolic disorders. Its role in patients with heart transplantation is not unifi ed. According to some authors, post-transplantation diabetes mellitus increases the risk of acute rejections and infections, increases the incidence of coronary artery disease of the graft and reduces long-term survival of patients with heart transplantation. On the other hand other studies did not confi rm these fi ndings. However, when diabetic patients were stratifi ed by disease severity, recipients with less severe disease achieved better survival. Accordingly, posttransplant survival was not signifi cantly different between recipients with uncomplicated diabetes and nondiabetic recipients. Diabetes alone should not be a contraindication to heart transplantation. Well-selected diabetic patients achieve the same survival as nondiabetic patients. Conversely, patients with complicated diabetes have signifi cantly worse survival. Therefore, given the critical shortage of transplantable organs, maximal benefi t may be achieved by exploring alternative treatment options in individuals with severe diabetes. These include use of high-risk transplant lists and destination therapy.
THE INDIVIDUAL TAILORING OF IMMUNOSUPPRESSIVE THERAPY AFTER HEART TRANSPLANTATION
Authors: Koloskova N. N. , Poptsov V. N. , Shevchenko A. О.
Published: April 2018

Heart transplantation is the «gold standard» of treatment severe heart failure. Immunosuppressive therapy aimed at the prevention of acute allograft rejection is the cornerstone of post-transplant management. In addition to its direct effects, immunosuppressive therapy is also involved in the generation of a number of post-transplant morbidities that limit the long-term outcome of heart transplant recipients. Given these data it appears that the individual tailoring of immunosuppressive therapy is of paramount importance in determining the outcome of heart transplantation. The goal of immunosuppressive therapy is to prevent rejection of the transplanted heart, while minimizing drug-related effects, such as infection, malignancy, diabetes, hypertension, and renal insuffi ciency. This review aimed is to analyze the protocols for the appointment of immunosuppressive therapy in various groups of recipients after heart transplantation.
SPECIAL ASPECTS OF IMPLANTATION OF A HEART PUMP SUPPORT SYSTEM AVK-N AS A «BRIDGE» TO HEART TRANSPLANTATION
Authors: Khalilulin T. A. , Zacharevich V. M. , Poptsov V. N. , Itkin G. P. , Shevchenko A. O. , Saitgareev R. Sh. , Goltz A. M. , Zakiryanov A. R. , Koloskova N. N. , Abramova N. N. , Zacharevich N. Y. , Nikitina E. A. , Danilina M. A. , Gautier S. V.
Published: April 2018

Aim:to develop an optimal surgical tactic for implantation of “AVK-N” system as a “bridge” to heart transplantation.

Materials and methods.17 patients were included. They were operated in the period from 2012 to October 2017 in Federal State Budgetary Institution «V.I. Shumakov National Medical Research Center of Transplantology and Artifi cial Organs». A tiny implantable system «Portable device for assisting cardiac circulation» (AVK-N; Russia) was used for replacing the pumping function of the left ventricle. All patients were examined according to the program of potential recipients for heart transplantation, before the applying of prolonged mechanical circulatory support. Among the operated patients there were 16 (94.1%) men and 1 (5.9%) woman, the average age was 52.64 ± 10.56 (from 33 to 67 years). All patients had congestive heart failure III–IV functional class according to NYHA, refractory to optimal drug therapy. Heart failure was triggered by dilated cardiomyopathy in 12 (70,58%) cases, and by postinfarction systolic dysfunction of the left ventricle in 5 (29,42%). Implantation of «AVK-N» system was performed to potential recipients of the donor heart with terminal stage of CHF with a decrease in LV ejection fraction up to 10%.

Results.As a result of this study there were developed several technological aspects facilitating the subsequent heart transplantation.

Conclusion.Our experience in optimizing the surgical tactics of the “AVK-N” system implantation as a bridge to heart transplantation, demonstrated the possibility and safety of its active use in both patients with terminal heart failure on the waiting list of heart transplantation and patients having temporary contraindications to HTX.
10-YEAR HEART TRANSPLANTATION EXPERIENCE IN NOVOSIBIRSK
Authors: Chernyavskiy A. M. , Doronin D. V. , Fomichev A. V. , Osipov D. E. , Shmyrev V. A. , Karaskov A. M.
Published: April 2018

Aim:to show the analysis of 10-year heart transplantation experience, the main complications and problems of the heart transplantation evaluation.

 Materials and methods.66 orthotopic heart transplantations were performed in patients with terminal chronic heart failure in our clinic since 2008. The heart failure causes were dilated cardiomyopathy in 46 cases (70%), postinfarction cardiosclerosis in 20 cases (30%). The recipients were 59 men (89%) and 7 women (11%), the average age was 46 ± 10 years. All patients had a severe left heart dilatation and critical left ventricular systolic dysfunction (left ventricular EDV 283 ± 58 ml, left ventricular ejection fraction 17 ± 5%, cardiac index 1.5 ± 0.3 l/min/m2). In some recipients, heart transplantation is performed in the second stage after preliminary implantation of mechanical circulatory support systems (LVAD, BVAD). The fi rst heart transplantations were performed using the biatrial technique (8 cases (12%)), the others were performed using the bicaval technique (58 cases (88%)). After the operation, patients received a three-component immunosuppressive therapy: the inhibitors of calcineurin, mycophenolate and corticosteroids.

Results.54 patients (82%) were discharged from the clinic after heart transplantation. The hospital mortality was 12 recipients (18%). The mortality in the long-term period was 10 recipients (15%). The hospital mortality cases were acute graft dysfunction in 5 cases (42%), infectious-septic complications in 4 cases (33%), massive intraoperative bleeding in 2 cases (17%), and total thrombosis of pulmonary artery in 1 case (8%). The death causes in the long-term period were acute transplant rejection in 4 cases (40%), coronary artery disease of the transplanted heart in 3 cases (30%), Kaposi’s sarcoma in 1 case (10%), lung cancer in 1 case (10%), and viral pneumonia in 1 case (10%).

Conclusion.Over a 10-year period, we have gained a lot of experience in heart transplantation; the procedures complications have been studied; the stages of preservation, harvesting and transportation of the donor heart, operative technique and postoperative treatment of patients have been improved to avoid complications in the early and long-term postoperative period.
EFFICACY OF MYOCARDIAL REVASCULARIZATION IN POTENTIAL RECIPIENTS OF HEART WITH THE CHRONIC ISCHEMIC HEART FAILURE
Authors: Gautier S. V. , Mironkov A. B. , Sakhovsky S. A. , Koloskova N. N. , Muminov I. I. , Spirina E. A. , Tunyaeva I. Yu. , Mironkov B. L.
Published: April 2018

Aim: to evaluate clinical effi ciency of percutaneous coronary interventions (PCI) at potential recipients of heart with the chronic ischemic heart failure (CHF).

Materials and methods. In this retrospective study results of treatment at 76 patients with CHF NYHA III and 36 patients with CHF NYHA IV by scheduled PCI are presented. Duration of observation was from 6 to 160 months. The age of patients at the time of intervention was 61,7 ± 0,62 years (from 33 to 76). 108 male and 4 female. Defi ned life expectancy and echocardiography parameters of the left ventricle (LV) of heart.  

Results.20 patients were died, 16 of them from cardiovascular events. 18 patients during this period undergo orthotopic heart transplantation (HT). The endovascular revascularization leads to LV volumes reduction, increase of ejection fraction and decrease of pulmonary artery pressure. Progress CHF is followed by negative dynamics of these characteristics and need of HT performance. In 74% of cases the effect of myocardial revascularization allows to provide increase in life expectancy of potential recipients of heart with the chronic ischemic heart failure.  

Conclusion.Performance of PCI at patients with the chronic ischemic heart failure can delay heart transplantation or become its alternative.
OF PHOTOPHERESIS IN KIDNEY TRANSPLANTATION
Authors: Faenko A. P. , Zulkarnayev A. B. , Chuksina Ju. Ju. , Fedulkina V. A. , Kantaria R. O. , Kildyushevskiy A. V. , Vatazin A. V.
Published: April 2018

Aim– to perform a comparative study of the long-term results of the combined use of extracorporeal photochemotherapy (photopheresis) and drug immunosuppression and standard immunosuppressive therapy in patients after kidney transplantation.

Materials and methods. An open cohort randomized study was conducted, including 60 patients with chronic kidney disease stage 5D. All patients underwent single-group cadaveric kidney transplantation. Patients were randomly divided into two groups. All transplants were paired, the fi rst kidney transplant was received by the patient of the main group, the second – by comparison group. 30 patients of the main group received standard protocol of immunosuppression and 10–15 sessions of photopheresis during the fi rst six months after transplantation. All patients of the comparison group received standard immunosuppressive therapy only. End points: primary – graft loss, surrogate – the number of acute rejection episodes and infectious complications, the dynamics of creatinine blood concentration, the glomerular fi ltration rate and daily proteinuria, the dynamics of tacrolimus C0 blood concentration. To study the mechanism of photopheresis action in the late postoperative period, we evaluated the immunological parameters: subpopulation of naive T-cells (CD3+CD4+CD45RO–CD28+), the level of CD28 molecule expression (MFI) on these cells and also – subpopulation of T-regulatory cells (CD3+CD4+CD25 (Hi)CD127–).

Results.The use of photopheresis leads to the graft function improvement in the late postoperative period: the creatinine concentration (p = 0.017) in the blood and daily proteinuria (p = 0.011) were lower in patients of the main group, the glomerular fi ltration rate was higher (p = 0.027). The incidence rate ratio (IRR) of rejection in the main group was signifi cantly lower than in the comparison group: 0.2509 (95% CI 0.05386, 0.9167), p = 0.0358. The risk of graft loss was also lower in the main group: IRR 0.2782 (95% CI 0.07562, 0.8657), p = 0.026, as well as the risk of infectious complications: IRR 0.3888 (95% CI 0.2754; 0, 5445), p < 0.0001. Survival rate of transplants was higher in the main group (Log Rank p = 0.009; Breslow p = 0.005). The use of photopheresis made it possible to reduce the concentration of tacrolimus in the late postoperative period (p = 0.0017) without increasing the risk of graft rejection. The photopheresis tolerogenic effect in the late postoperative period may be due to an increase in the population of T-regulatory cells with the CD3+CD4+CD25(Hi)+CD127– phenotype compared to the patients which received only standard immunosuppressive therapy (p = 0.024).

Conclusion.The preventive use of photopheresis contributes to improvement of the kidney transplantation long-term outcomes. Further studies are needed to study the mechanisms of photopheresis action and markers of partial immunological tolerance to the allograft.
LIVER TRANSPLANTATION FROM SEXAGENARIAN AND OLDER
Authors: Gautier S. V. , Kornilov М. N. , Miloserdov I. A. , Minina M. G. , Kruglov D. N. , Zubenko S. I.
Published: April 2018

Donor organs shortage leads to extending criteria for deceased liver donation in the whole world.

Aim:to compare results of deceased donor liver transplantation (DDLT) depending of donor age over 60 years old.

Materials and methods:the study includes 390 DDLT from January 2010 to November 2017. All liver donors separated by age for two groups: I – 60 years and older (n = 26); II – younger than 60 years (n = 364). All donors were standardized by demographic, laboratory fi ndings and inotropic drug requirement.

 Results:no difference between both groups in severity of ischemia-reperfusion injury, ICU or in-hospital staying (median 2 and 7,5 days respectively) was found. There is also no difference between biliary or vascular complication rate. 5-year actuarial survival rate found no difference between both groups (I: 70%: II: 76%, p = 0,54).

Conclusion.Using grafts from donors older than 60 years don’t worsen early and late results of DDLT. Care should be taken to avoid other risk factors (cold ischemia time, warm ischemia time).
CULTIVATION OF HUMAN LIVER CELLS AND ADIPOSE-DERIVED MESENCHYMAL STROMAL CELLS IN PERFUSION BIOREACTOR
Authors: Basok Yu. В. , Grigoryev A. M. , Kirsanova L. A. , Shmerko N. P. , Khizroev К. M. , Sevastianov V. I.
Published: April 2018

Aim:to show the progress of the experiment of cultivation of human liver cells and adipose-derived mesenchymal stromal cells in perfusion bioreactor.

Materials and methods.The cultivation of a cell-engineered construct, consisting of a biopolymer microstructured collagen-containing hydrogel, human liver cells, adipose-derived mesenchymal stromal cells, and William’s E Medium, was performed in a perfusion bioreactor.

Results.On the 7th day large cells with hepatocyte morphology – of a polygonal shape and a centrally located round nucleus, – were present in the culture chambers of the bioreactor. The metabolic activity of hepatocytes in cell-engineered constructs was confi rmed by the presence of urea in the culture medium on the seventh day of cultivation in the bioreactor and by the resorption of a biopolymer microstructured collagen-containing hydrogel.
COMPLEX APPROACH FOR PORTABLE CRYOPRESERVATION OF SEGMENTS OF BLOOD VESSELS WITH POLYDIMETHYLSILOXANE
Authors: Lauk-Dubitsky S. E. , Astrelina T. A. , Fedyunin A. A. , Burkov I. A. , Kildyushov E. M. , Lischuk S. V. , Novikov I. A. , Pushkarev A. V. , Brumberg V. A. , Shakurov A. V. , Samchuk D. P. , Kobzeva I. V. , Suchkova Yu. B. , Nikitina V. A. , Karaseva T. V. , Bushmanov A. Yu. , Samoilov A. S.
Published: April 2018

Aim.To develop a safe protocol for cryopreservation of segments of iliac arteries straight after their retrieval from post-mortem donor with the use of polydimethylsiloxane as a coolant and cryoprotectant.

Materials and methods.Eleven segments of iliac arteries were retrieved from post-mortem donor and divided into four groups including control. Based on preliminary heat and cold transfer mathematical modeling and tests with tissueequivalent phantom arterial segments were placed on plastic mounts and cryopreserved by following protocol: groups 1 and 2 were immersed in polydimethylsiloxane and cooled rapidly at 180 °С/min to –75 °С. Group 3 segments were cryopreserved at 1,6 °С/min in PDMS – fi lled cryo-container placed in the freezer at –80 °С. All segments were defrosted by immersion in PDMS at +24 °С and then examined for morphology changes by histological methods and SEM. EDS analysis with the use of AzTech software also was performed for Si – content evaluation. Restricted biomechanical tests were conducted for group 2 segments.

Results.There were no signifi cant morphological differences between segments of the control and cryopreserved groups except for the segment with slow cooling.

Conclusion.Mobile cryopreservation may allow increasing the effi ciency of retrieval of a large number of donor tissues for possible later use in the processing of bioprostheses of blood vessels; or, after decellularization, as well as tissue-specifi c matrices for tissue-engineering blood vessels.
INFLUENCE OF bFGF, SDF-1α, OR VEGF INCORPORATED INTO TUBULAR POLYMER SCAFFOLDS ON THE FORMATION OF SMALL-DIAMETER TISSUE-ENGINEERED BLOOD VESSEL IN VIVO
Authors: Antonova L. V. , Sevostyanova V. V. , Kutikhin A. G. , Velikanova Е. A. , Matveeva V. G. , Glushkova T. V. , Mironov A. V. , Krivkina E. O. , Barbarash O. L. , Barbarash L. S.
Published: April 2018

Aim. To evaluate the potential synergistic effects of basic fi broblast growth factor (bFGF) and stromal cell-derived factor-1α (SDF-1α) complemented with VEGF compared to VEGF alone when being added into poly(3-hydroxybutyrateco-3-hydroxyvalerate) / poly(ε-caprolactone) vascular grafts implanted into rat abdominal aorta for 3, 6, or 12 months.

Materials and methods. Utilizing emulsion electrospinning, we fabricated one-layer vascular grafts with either VEGF, bFGF, or SDF-1α, and two-layer vascular grafts with VEGF incorporated into the inner layer and bFGF and SDF-1α incorporated into the outer layer following structural evaluation, tensile testing, andin vivotesting using a rat abdominal aorta replacement model.

Results. Grafts containing all three growth factors had a 100% primary patency rate. The combination of bFGF, SDF-1α and VEGF improved morphology and mechanical properties of the grafts. Furthermore, such combination of the bioactive factors promoted endothelialization compared to VEGF alone. In addition, bFGF induced a rapid formation of a SMC layer.

Conclusion. Taking together, these fi ndings show that the incorporation of bFGF and SDF-1α into the vascular grafts in combination with VEGF enhances vascular tissue regeneration and provides a higher primary patency rate.
Historiadores e memória da historiografia no Rio Grande do Sul: a edição póstuma de Terra Gaúcha (1955), de Simões Lopes Neto
Authors: Zalla Jocelito
Published: April 2018

O objetivo deste artigo é examinar o aparato paratextual póstumo de Terra Gaúcha (1955), ensaio histórico inédito do escritor regionalista João Simões Lopes Neto (1865-1916). Quais eram as condições (e os limites) da apropriação da obra e do autor no período da edição? Para tanto, busco aliar uma história editorial do manuscrito a uma tipologia das notas de rodapé elaboradas pelos historiadores-editores. A edição de Terra Gaúcha visava legitimar as posições adotadas pelo grupo de historiadores-folcloristas marginal no âmbito do Instituto Histórico e Geográfico do Rio Grande do Sul (IHGRS), criando um precursor nobre e uma narrativa de memória para seu projeto de escrita de história. Essa operação passou pela atualização científica do texto, através da inclusão de notas de rodapé bibliográficas e documentais, e pela concessão ideológica a teses então dominantes a respeito da formação do Rio Grande do Sul. Essa autorização parcial, no entanto, acabou por reforçar o veto à identidade profissional de historiador para Simões Lopes Neto.
GRAMSCI, AS REVISTAS, O INTELECTUAL E A EDUCAÇÃO
Authors: Reis Egberto Pereira dos , Rothen José Carlos
Published: April 2018

RESUMO: Neste artigo, abordamos a forma como Gramsci compreendeu o importante papel dos periódicos, principalmente, as revistas como meio difusor de uma nova concepção de mundo na vida do operariado e do povo em geral. Para que os periódicos atinjam seus objetivos, é necessário que se estabeleça o princípio educativo, em que intelectuais orgânicos e subalternos da sociedade estabelecem a troca de saberes. Assim, constatamos que o intercâmbio educacional, dá-se dentro das revistas, como ocorreu com os periódicos L’Ordine Nuovo e Il Grido. Desse modo, segundo Gramsci, os periódicos foram decisivos para que o operariado de seu tempo pudesse compreender a própria realidade e os mecanismos de exploração da classe dominante. Desta forma, se estabelece a chamada guerra de posição. Em outras palavras, as batalhas que são travadas nas revistas e na sociedade civil em busca da hegemonia e, consequentemente, da reforma intelectual e moral.
DETERMINANT FACTORS FOR UNDERGRADUATE STUDENT’S DROPOUT IN AN ACCOUNTING STUDIES DEPARTMENT OF A BRAZILIAN PUBLIC UNIVERSITY
Authors: Durso Samuel de Oliveira , Cunha Jacqueline Veneroso Alves da
Published: April 2018

ABSTRACT: The purpose of this article was to identify explanatory factors for undergraduate student’s dropout from the Accounting program of a Brazilian public university. The theoretical platform that guided the study was formulated using three evasion models related to higher education. The survey database consisted of socioeconomic and demographic information of 371 students. The research used quantitative and qualitative methodologies to reach the proposed goal. Quantitative data analysis was performed through logistic regression. The model proposed by the study was able to accurately predict 77% of the cases of dropout/completion from the sample. The qualitative step was based on five semi-structured interviews with those in the sample who dropped out of their studies. The findings of the research have helped understand the phenomenon of undergraduate student dropout from the Accounting program and stresses the importance of rethinking public policies for the retention of talent and, especially, of those students who depend on their work to maintain their studies.
Frequency and antimicrobial susceptibility of Staphylococcus pseudintermedius in dogs with otitis externa
Authors: Scherer Carolina Boesel , Botoni Larissa Silveira , Coura Fernanda Morcatti , Silva Rodrigo Otávio , Santos Rafael Dantas dos , Heinemann Marcos Bryan , Costa-Val Adriane Pimenta
Published: April 2018

ABSTRACT: Infections by Staphyloccocus pseudintermedius in the skin of dogs have been object of studies, since such microorganisms often present multiple resistance to antibiotics. This study aimed to identify and evaluate the antimicrobial susceptibility of Staphylococcus pseudintermedius (SP) strains isolated from dogs with otitis. Swabs from both ears of 52 dogs with otitis (n=104) were included. Bacteria were cultured using Muller-Hinton agar (supplemented with 5% equine blood and incubated at 37°C for 24 to 48 hours. All colonies underwent biochemical evaluation for identification of staphylococci. The identity of colonies as SP was confirmed by polymerase chain reaction. The antimicrobial susceptibility of SP strains was evaluated by disk diffusion. The presence of the gene mecA was evaluated in all SP isolates by PCR. Forty-four SP strains were isolated from swabs of 31 dogs (31/52, 59.6%). Seventy-five percent of the strains were susceptible to cephalexin and 93.2% to amoxicillin plus clavulanic acid. Less than 23% of the strains were susceptible to penicillin. For non-beta-lactam antimicrobials, 63.6% of the strains showed resistance to sulfamethoxazole-trimethoprim, 61.4% to tetracycline, and 38, 64% to enrofloxacin. Aminoglycoside resistance rate was 27.3% for gentamicin. Resistance to oxacillin in vitro was detected in 13 of the 44 strains (29, 55%). A total of 12 strains (27.3%) were positive for mecA gene and five of these 12 strains were susceptible to in vitro oxacillin. Twenty-six (59, 1%) strains were resistant to three or more classes of antimicrobials, and classified as multi resistant. Our results showed high frequency of SP and multi resistant isolates to antimicrobials commonly used in veterinary.
SABERES SOBRE PROCESSO DE ENFERMAGEM NO BANCO DE LEITE HUMANO
Authors: Marchiori Giovanna Rosário Soanno , Alves Valdecyr Herdy , Rodrigues Diego Pereira , Santos Márcia Vieira dos , Branco Maria Bertilla Lutterbach Riker , Gabriel Adriana Duarte
Published: April 2018

RESUMO Objetivo: analisar os saberes dos enfermeiros sobre o processo de enfermagem como instrumento da Sistematização da Assistência de Enfermagem no Banco de Leite Humano. Método: estudo descritivo, exploratório, qualitativo, realizado no segundo trimestre de 2015 em sete Bancos de Leite Humano do Estado do Espírito Santo. Com essa perspectiva foram entrevistadas nove enfermeiras atuantes no serviço de saúde. Os dados foram submetidos à análise de conteúdo na modalidade temática. Resultados: O processo de enfermagem pode ser considerado um organizador dos trabalhos, no espaço do Banco de Leite Humano. Tais saberes no cotidiano e o conhecimento da aplicabilidade do processo de enfermagem necessitam ser um pressuposto para sustentar as ações dos enfermeiros nos Bancos de Leite Humano. Conclusão: as análises indicaram que o trabalho do enfermeiro deve estar embasado em uma metodologia científica, mas há uma fragmentação na efetivação das etapas do processo de enfermagem. Faz-se necessária a elaboração de um instrumento que possibilite a efetivação da Sistematização da Assistência de Enfermagem, mediante o instrumento processo de enfermagem.
AVALIAÇÃO DA SATISFAÇÃO DE FAMILIARES DE PACIENTES ATENDIDOS EM UNIDADES DE TERAPIA INTENSIVA: REVISÃO INTEGRATIVA
Authors: Neves Josiele de Lima , Schwartz Eda , Guanilo Maria Elena Echevarria , Amestoy Simone Coelho , Mendieta Marjoriê da Costa , Lise Fernanda
Published: April 2018

RESUMO Objetivo: analisar a produção científica relacionada às evidências acerca da satisfação de familiares de pacientes de UTI e os instrumentos utilizados para sua avaliação. Metodo: revisão integrativa na qual foram analisados artigos publicados entre 2005 e 2015, em inglês, português ou espanhol, nas bases de dados PUBMED/MEDLINE e LILACS e a biblioteca SciELO. Utilizou-se como estratégia de busca: personal satisfactional OR satisfaction AND family. Para coleta de dados dos artigos elaborou-se um instrumento com informações como: título, autores, ano de publicação e revista, objetivo do estudo, delineamento, participantes, local da pesquisa, temática principal e resultados. Resultados: atenderam aos critérios de inclusão 27 produções. Foram identificados quatro instrumentos utilizados para avaliar a satisfação de familiares de pacientes na UTI o Critical Care Family Satisfaction Survey, Family Satisfaction in the Intensive Care Unit, Critical Care Family Needs Inventory e o Quality of Dying and Death. Os estudos abordaram a satisfação dos familiares em relação às suas necessidades e tomadas de decisão, satisfação quanto a cuidados paliativos, evidenciou-se, ainda, estudos de adaptação transcultural e validação de instrumentos. Quanto ao nível de evidência, os estudos se concentram nos níveis II a VI. Conclusão: a análise da produção científica sobre a satisfação de familiares de pacientes de UTI permitiu evidenciar que o fator que mais contribui na promoção da satisfação da família foi a qualidade do atendimento.
RELAÇÃO PEDAGÓGICA NO ENSINO PRÁTICO-REFLEXIVO: ELEMENTOS CARACTERÍSTICOS DO ENSINO DA INTEGRALIDADE NA FORMAÇÃO DO ENFERMEIRO
Authors: Lima Margarete Maria de , Reibnitz Kenya Schmidt , Kloh Daiana , Silva Kênia Lara da , Ferraz Fabiane
Published: April 2018

RESUMO Objetivo: identificar os elementos da relação pedagógica no ensino prático-reflexivo que caracterizem o ensino da integralidade. Método: pesquisa qualitativa, do tipo estudo de caso. Coleta de dados ocorreu de maio de 2013 a setembro de 2014, com oito docentes de disciplinas do eixo integrador dos quatro últimos semestres de um Curso de Graduação em Enfermagem. Utilizou-se a triangulação de técnicas para coleta de dados, análise documental, observação não participante e entrevistas individuais. Análise de dados guiada pela proposta operativa de Minayo. Resultados: a relação pedagógica no Curso de Graduação em Enfermagem está fundamentada em elementos que potencializam o ensino da integralidade, trazendo para o contexto da formação exemplos da prática, conectando o que foi visto na teoria com o encontrado nos serviços de saúde e oportunizando um processo de reflexão para o estudante e para o docente. Conclusão: os elementos da relação pedagógica no ensino prático-reflexivo que caracterizam a aprendizagem a partir do princípio da integralidade, durante a formação do enfermeiro, estão relacionados à conexão teoria e prática, ao desenvolvimento do talento artístico profissional e ao processo de reflexão na e sobre a ação. A relação pedagógica no curso está caminhando para formar profissionais competentes para atuar diante de situações incertas e conflituosas encontradas nos serviços de saúde.
ESTRATÉGIAS DIDÁTICAS NO PROCESSO DE ENSINO-APRENDIZAGEM DE GESTÃO EM ENFERMAGEM
Authors: Santos José Luís Guedes dos , Souza Carla Simone Bittencourt Netto de , Tourinho Francis Solange Vieira , Sebold Luciara Fabiane , Kempfer Silvana Silveira , Linch Graciele Fernanda da Costa
Published: April 2018

RESUMO Objetivo: analisar as estratégias didáticas utilizadas no processo de ensino e aprendizagem de gestão em enfermagem. Método: revisão integrativa da literatura na base de dados Literatura Latino-Americano e do Caribe em Ciências da Saúde e Scientific Electronic Library Online, utilizando-se os seguintes descritores e palavras-chave: ensino, enfermagem, gestão, administração, gerenciamento, educação em enfermagem, organização e administração, educação a distância e gestão em saúde. A amostra foi composta por 23 publicações. Resultados: as estratégias didáticas utilizadas no ensino de gestão em enfermagem estão relacionadas, principalmente, ao método de trabalho independente e método de trabalho em grupo. Destacaram-se as estratégias que possibilitam a articulação entre teoria e prática, tais como: planejamento estratégico situacional, metodologia da problematização com o método do Arco de Maguerez, seminários, oficinas e exposições dialogadas interativas. Conclusão: o ensino de gestão em enfermagem está acompanhando as mudanças pedagógicas da educação superior na área da saúde.
COMPORTAMENTOS DE RISCOS À SAÚDE DE HOMENS DA REGIÃO SUL DO BRASIL
Authors: Arruda Guilherme Oliveira de , Marcon Sonia Silva
Published: April 2018

RESUMO Objetivo: avaliar a prevalência de comportamentos de riscos à saúde e associar com características sociodemográficas. Método: estudo transversal, do tipo inquérito domiciliar, desenvolvido mediante aplicação de instrumentos estruturados, com 421 homens adultos, selecionados a partir de amostragem aleatória sistemática. Foram realizadas a análise univariada e a análise múltipla, por meio de Regressão Logística. Resultados: idade entre 40 e 50 anos e as classes econômicas B e C associaram-se ao consumo abusivo de álcool (30,4%); renda de 2,1 a 4,0 salários mínimos, escolaridade superior e ter religião ao tabagismo (19,5%); trabalhar, estar empregado e ter ensino médio/superior à atividade física insuficiente (86,2%); não trabalhar, renda maior que seis salários e não ter plano de saúde à dieta inadequada (39,2%); não ter companheira, religião e ser empregado à situação vacinal inadequada (24,9%); idade entre 50 e 59 anos, estar aposentado/licença médica e ter plano de saúde à não realização de exames (42,3%); renda maior que seis salários e classe econômica C a não realização de lazer (36,3%). Conclusão: os comportamentos de risco à saúde estão associados a diferentes fatores a serem considerados na atenção aos homens.
ASPECTOS PSICOSSOCIAIS DA QUALIDADE DE VIDA DE RECEPTORES DE TRANSPLANTE HEPÁTICO
Authors: Aguiar Maria Isis Freire de , Alves Naiana Pacífico , Braga Violante Augusta Batista , Souza Ângela Maria Alves e , Araújo Michell Ângelo Marques , Almeida Paulo César de
Published: April 2018

RESUMO Objetivo: avaliar a dimensão psicossocial da qualidade de vida de pacientes antes e depois do transplante hepático. Método: estudo descritivo, transversal, com abordagem quantitativa, com 150 pacientes submetidos ao transplante de fígado em seguimento a partir do sexto mês, no ambulatório de um centro de referência em transplante hepático. A coleta de dados foi realizada a partir da aplicação de um instrumento com dados sociodemográficos/clínicos e do questionário Liver Disease Quality of Life. Foi utilizada análise estatística descritiva, teste t de Student para comparação das médias dos domínios e Games-Howell para comparações múltiplas. Resultados: houve melhoria nos níveis de qualidade de vida pós-transplante nos quatro domínios avaliados (<0,0001), com maior elevação de escores para os domínios: preocupação (55,5 vs 87,9) e estigma da doença hepática (58,6 vs 93,7). Conclusão: o estudo demonstrou que os pacientes submetidos ao transplante hepático obtiveram uma melhoria significativa da percepção da qualidade de vida no que diz respeito à dimensão psicossocial, sendo mais perceptiva nos domínios preocupação e estigma da doença hepática.
Espalhamento Bhabha: Um Estudo Detalhado
Authors: Nóbrega Fábio Köpp , Mackedanz Luiz Fernando
Published: April 2018

Resumo Neste artigo, vamos estudar alguns conceitos fundamentais em física de partículas através do estudo detalhado de um processo específico da Eletrodinâmica Quântica (QED): o espalhamento Bhabha em ordem dominante (Leading Order - LO). Este ocorre na interação entre um elétron e sua antipartícula, o pósitron, sendo um dos processos básicos da QED. Nossa escolha em trabalhar este processo deve-se a riqueza de detalhes proporcionada pelas duas possibilidades (canais) de interação, que servem para ilustrar o cálculo da interferência entre as possibilidades. Além disso, esse processo é utilizado para determinar a luminosidade de um determinado colisor, o que garante maior precisão nas medidas de outras grandezas relevantes para a análise das interações entre partículas. Finalmente, comparamos a predição da QED com os resultados do experimento DESY-PETRA-TASSO.
“Travesti”, “mulher transexual”, “homem trans” e “não binário”: interseccionalidades de classe e geração na produção de identidades políticas
Authors: Carvalho Mario
Published: April 2018

Resumo Este artigo aborda a construção de identidades políticas no movimento de travestis, mulheres transexuais e homens trans ao longo da última década no Brasil. Reúno diferentes materiais etnográficos a fim de localizar as transformações em tais construções, principalmente em relação ao modo como os marcadores sociais de classe e geração aparecem na polarização entre uma “fixidez” e uma “fluidez” de gênero no campo político. O material utilizado nesta análise é composto por observações de encontros ativistas, entrevistas com lideranças do movimento e observações do ativismo na internet. Organizo a análise a partir de situações de conflito, nas quais dois encontros são de especial interesse: o XVI Encontro Nacional de Travestis e Transexuais (2009) e o I Encontro Nacional de Homens Trans (2015), momentos marcados pela disputa em torno das categorias identitárias em questão.
Decir el propio género. Feminidades, usos del género gramatical y nombre propio
Authors: Vacarezza Nayla Luz
Published: April 2018

Resumen Basado en la lectura crítica de entrevistas en profundidad, este artículo ofrece un análisis acerca del modo en que las feminidades trans y no trans (o cis) se producen performativamente a través del uso repetido del género femenino gramatical en el discurso autorreferencial y también por medio de la utilización de un nombre propio femenino en su vida cotidiana. En un momento histórico de profundos cambios sociales y culturales relacionados con el reconocimiento, en el año 2012, de la identidad de género de las personas trans en la Argentina (Ley 26743), se examina también el marco legal restrictivo para la asignación de los nombres propios y se analizan las particularidades sociales e históricas del nombre trans. Se utilizan para el análisis conceptos de la teoría de la performatividad del género elaborada por Judith Butler, en diálogo con conceptualizaciones del campo de los Estudios Transgénero.
Márgenes de la ley: epifenómenos de violencia biopolítica
Authors: Navarro Pablo Pérez
Published: April 2018

Resumen El objetivo de este artículo es desarrollar un marco teórico desde el cual repensar las formas de violencia estatal implícitas en un conjunto interrelacionado de prácticas institucionales, administrativas y judiciales en los ámbitos de las políticas genéricas, de la sexualidad y de la diversidad relacional. A través del caso de la España post-“matrimonio igualitario”, se muestra cómo la introducción del concepto de “orden público” en los sistemas judiciales modernos ha jugado, y continúa haciéndolo hoy en día, un importante papel en la administración biopolítica de poblaciones.
“O Rio de Janeiro é uma terra de homens vaidosos”: mulheres, masculinidade e dinheiro junto ao funk carioca
Authors: Mizrahi Mylene
Published: April 2018

Resumo A partir da articulação entre gênero e materialidade tomamos o dinheiro como objeto estético para evidenciar a relacionalidade da pessoa masculina funk . O dinheiro revela-se como adorno, como articulador de relações e como substância. A mulher, que em algumas leituras é pensada como objetificada, revela as potências do feminino que compõem o homem. Como desdobramento da análise, reconceituamos o corpo e a pessoa, tomando-os como não circunscritos, repensando junto a noção de “objeto”. Igualmente, trazemos um sentido outro para a noção de “ostentação”, deslocando o consumo de uma chave moralizante.