bluuebunny/crossref_metadata_2025 huggingface dataset:
Associations between cardiorespiratory fitness and diverticulitis in older adults
Authors: Song Bong Kil , Saavedra Joey M. , Lefferts Elizabeth C. , Brellenthin Angelique G. , Lee Duck-chul
Published: September 2022

Objectives

Examine the independent and joint associations of cardiorespiratory fitness (CRF) and body mass index (BMI) with the prevalence of diverticulitis in older adults.

Methods

476 older adults (61% Female; 71 ± 5 years) with no history of myocardial infarction, stroke, cancer, inflammatory bowel disease, or diabetes were included in this cross-sectional study. Diverticulitis cases were identified by self-reported physician diagnosis from the medical history questionnaire. Logistic regression was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) of the prevalence of diverticulitis by tertiles of CRF and BMI category. CRF and BMI were further dichotomized into either “unfit” (the lowest one-third of CRF), “fit” (the upper two-thirds of CRF), “overweight/obese” (BMI ≥25.0 kg/m2), or “normal-weight” (BMI <25.0 kg/m2) to investigate the joint association of CRF and BMI with diverticulitis.

Results

Thirty-five (7.4%) participants were identified as having diverticulitis. Compared with the lowest CRF tertile, the ORs (95% CIs) of diverticulitis were 0.52 (0.22–1.22) and 0.33 (0.12–0.94) in the middle and upper CRF tertiles, respectively, after adjusting for potential confounders. After further adjustment for BMI, the association was no longer significant with ORs (95% CIs) of 0.55 (0.23–1.33) and 0.37 (0.12–1.10) in middle and upper CRF tertiles, respectively. Compared with the normal-weight group, the ORs (95% CIs) of diverticulitis were 2.86 (1.05–7.79) and 2.98 (0.95–9.35) in the overweight and obese groups, respectively, after adjusting for possible confounders and CRF. Compared with the “unfit and overweight/obese” group in the joint analysis, the OR (95% CI) of diverticulitis was 0.16 (0.04–0.61) in the “fit and normal-weight” group.

Conclusions

Older adults who maintain higher CRF and lower BMI may have significantly lower odds of diverticulitis, with the lowest odds found in the normal-weight and fit older adults.
Projection in genomic analysis: A theoretical basis to rationalize tensor decomposition and principal component analysis as feature selection tools
Authors: Taguchi Y-h. , Turki Turki
Published: September 2022

Identifying differentially expressed genes is difficult because of the small number of available samples compared with the large number of genes. Conventional gene selection methods employing statistical tests have the critical problem of heavy dependence ofP-values on sample size. Although the recently proposed principal component analysis (PCA) and tensor decomposition (TD)-based unsupervised feature extraction (FE) has often outperformed these statistical test-based methods, the reason why they worked so well is unclear. In this study, we aim to understand this reason in the context of projection pursuit (PP) that was proposed a long time ago to solve the problem of dimensions; we can relate the space spanned by singular value vectors with that spanned by the optimal cluster centroids obtained from K-means. Thus, the success of PCA- and TD-based unsupervised FE can be understood by this equivalence. In addition to this, empirical threshold adjustedP-values of 0.01 assuming the null hypothesis that singular value vectors attributed to genes obey the Gaussian distribution empirically corresponds to threshold-adjustedP-values of 0.1 when the null distribution is generated by gene order shuffling. For this purpose, we newly applied PP to the three data sets to which PCA and TD based unsupervised FE were previously applied; these data sets treated two topics, biomarker identification for kidney cancers (the first two) and the drug discovery for COVID-19 (the thrid one). Then we found the coincidence between PP and PCA or TD based unsupervised FE is pretty well. Shuffling procedures described above are also successfully applied to these three data sets. These findings thus rationalize the success of PCA- and TD-based unsupervised FE for the first time.
Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages
Authors: Cohen Allison , Jeng Edwin E. , Voorhies Mark , Symington Jane , Ali Nebat , Rodriguez Rosa A. , Bassik Michael C. , Sil Anita
Published: September 2022

The fungal pathogenHistoplasma capsulatum(Hc) invades, replicates within, and destroys macrophages. To interrogate the molecular mechanisms underlying this interaction, we conducted a host-directed CRISPR-Cas9 screen and identified 361 genes that modify macrophage susceptibility toHcinfection, greatly expanding our understanding of host gene networks targeted byHc. We identified pathways that have not been previously implicated inHcinteraction with macrophages, including the ragulator complex (involved in nutrient stress sensing), glycosylation enzymes, protein degradation machinery, mitochondrial respiration genes, solute transporters, and the ER membrane complex (EMC). The highest scoring protective hits included the complement C3a receptor (C3aR), a G-protein coupled receptor (GPCR) that recognizes the complement fragment C3a. Although it is known that complement components react with the fungal surface, leading to opsonization and release of small peptide fragments such as C3a, a role for C3aR in macrophage interactions with fungi has not been elucidated. We demonstrated that whereas C3aR is dispensable for macrophage phagocytosis of bacteria and latex beads, it is critical for optimal macrophage capture of pathogenic fungi, includingHc, the ubiquitous fungal pathogenCandida albicans, and the causative agent of Valley FeverCoccidioides posadasii. We showed that C3aR localizes to the early phagosome duringHcinfection where it coordinates the formation of actin-rich membrane protrusions that promoteHccapture. We also showed that the EMC promotes surface expression of C3aR, likely explaining its identification in our screen. Taken together, our results provide new insight into host processes that affectHc-macrophage interactions and uncover a novel and specific role for C3aR in macrophage recognition of fungi.
Avaliação Multicritério em Processos de Decisão
Authors: Dias Luís Cândido
Published: September 2022

Muitos processos de decisão – sobretudo os mais importantes – debruçam-se sobre decisões que podem ter consequências múltiplas a nível económico, ambiental, social ou técnico. O processo de decisão deve então abarcar não um único, mas vários critérios na avaliação das diferentes alternativas. Este livro introduz o tema da avaliação multicritério em processos de decisão, desde a fase de estruturação, na qual se define o que avaliar e como avaliar, à obtenção de conclusões que se desejam robustas face às dúvidas que possam existir. São discutidos alguns métodos demasiado simplistas por vezes utilizados na prática, e são apresentados em detalhe alguns processos bem fundamentados para conduzir uma avaliação multicritério. O texto pretende ser pedagógico, sem deixar de identificar alguns dos avanços mais recentes na área do apoio multicritério à decisão.
Determinantes de la competitividad de destinos de turismo en países seleccionados de Latinoamérica: un enfoque a partir del modelo de gravedad
Authors: Lombana-Coy Jahir , Palacios-Chacón Lorena
Published: September 2022

La competitividad de destinos turísticos ha sido ampliamente estudiada teniendo en cuenta diversas unidades de análisis e instrumentos de medición. Sin embargo, el estudio con datos bilaterales utilizando el modelo de gravedad ha sido relativamente escaso. Por lo anterior, esta investigación analiza, a través de este instrumento, los efectos de variables macroeconómicas, de infraestructura y propios de la industria turística en la competitividad de destino para 19 países seleccionados de Latinoamérica desde una perspectiva comparada y ampliada. Los resultados son consistentes con la literatura en variables de infraestructura y específicas de la industria. A su vez, se debe ser cauto con los resultados macroeconómicos, por la ausencia de datos específicamente relacionados con el sector y por los efectos disímiles que se puedan presentar en el corto, mediano y largo plazo. Se encuentra que el acceso a internet y la disponibilidad de lugares declarados como patrimonio mundial son atractivos para los turistas y por tanto podrían ser efecto de priorización en las políticas públicas.
Comparison Between 3-Dimensional-Printed Titanium and Polyetheretherketone Cages: 1-Year Outcome After Minimally Invasive Transforaminal Interbody Fusion
Authors: Kim Do-Yeon , Kwon O-Hyuk , Park Jeong-Yoon
Published: September 2022

Objective: Three-dimensional (3D)-printed titanium implants have been developed recently, but the utility is not yet proven. The aim of this study was to compare 3D-printed titanium and polyetheretherketone (PEEK) implants after minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF).Methods: Between October 2018 and September 2021, we retrospectively analyzed 83 patients who underwent single-level MIS-TLIF (3D-printed titanium, 40; PEEK, 43). Radiologic parameters were assessed with x-ray and computed tomography (CT) at postoperative 1 week, 6 months, and 1 year. Clinical status was evaluated using Oswestry Disability Index, visual analogue scale score, and Bridwell fusion grading was assessed on 6-month and 1-year postoperative CT.Results: There were no differences between the 2 groups in demographics and clinical outcomes. At 1-year of follow-up, the reported 3D-printed titanium fusion grades were grade I: 77.5% (31 patients), grade II: 17.5% (7 patients), and grade III: 5% (2 patients). The PEEK fusion grades were grade I: 51.2% (22 patients), grade II: 41.9% (18 patients), and grade III: 7.0% (3 patients). For overall fusion rate (grade I + II), there was no difference between the 2 cages (95.0% vs. 93.0%, p = 0.705), but grade I was reported at a higher incidence in 3D-printed titanium than PEEK (77.5% vs. 51.2%, p = 0.013). There was no difference between cages based on subsidence and complications.Conclusion: There were no significant differences in the overall fusion rate for MIS-TLIF surgery between 3D-printed titanium and PEEK, but the fusion grade was better in 3D-printed titanium than in PEEK. Long-term follow-up is required to verify the effectiveness.
Biomechanical Effects of Proximal Polyetheretherketone Rod Extension on the Upper Instrumented and Adjacent Levels in a Human Long-Segment Construct: A Cadaveric Model
Authors: Pereira Bernardo de Andrada , Lehrman Jennifer N. , Sawa Anna G.U. , Wangsawatwong Piyanat , Godzik Jakub , Xu David S. , Turner Jay D. , Kelly Brian P. , Uribe Juan S.
Published: September 2022

Objective: The high mechanical stress zone at the sudden transition from a rigid to flexible region is involved in proximal junctional kyphosis (PJK) physiopathology. We evaluated the biomechanical performance of polyetheretherketone (PEEK) rods used as a nontraditional long semirigid transition phase from a long-segment metallic rod construct to the nonfused thoracic spine.Methods: Pure moment range of motion (ROM) tests (7.5 Nm) were performed on 7 cadaveric spine segments followed by compression (200 N). Specimens were tested in the following conditions: (1) intact; (2) T10-pelvis pedicle screws and rods (PSRs); and (3) extending the proximal construct to T6 using PEEK rods (PSR+PEEK). T10–11 rod strain, T9 anterolateral bone strain, and T10 screw bending moments were analyzed.Results: At the upper instrumented vertebra (UIV)+1, PSR+PEEK versus PSR significantly decreased ROM in flexion (115%, p = 0.02), extension (104%, p = 0.003), left lateral bending (46%, p = 0.02), and right lateral bending (63%, p = 0.008). Also, at UIV+1, PSR+PEEK versus intact significantly decreased ROM in flexion (111%, p = 0.01) and extension (105%, p = 0.003). The UIV+1 anterior column bone strain was significantly reduced with PSR+PEEK versus PSR during right lateral bending (p = 0.02). Rod strain polarities reversed with PEEK rods in all loading directions except compression.Conclusion: Extending a long-segment construct using PEEK rods caused a decrease in adjacent-level hypermobility as a consequence of long-segment immobilization and also redistributed the strain on the UIV and adjacent levels, which might contribute to PJK physiopathology. Further studies are necessary to observe the clinical outcomes of this technique.
Pathological Classification of the Intramedullary Spinal Cord Tumors According to 2021 World Health Organization Classification of Central Nervous System Tumors, a Single-Institute Experience
Authors: Park Sung-Hye , Won Jae Kyung , Kim Chi Heon , Phi Ji Hoon , Kim Seung-Ki , Choi Seung Hong , Chung Chun Kee
Published: September 2022

According to the new 2021 World Health Organization (WHO) classification of tumors of the central nervous system (CNS) the classification of the primary intramedullary spinal cord tumors (IM-SCT) follows that of CNS tumors. However, since the genetics and methylation profile of ependymal tumors depend on the location of the tumor, the ‘spinal (SP)’ should be added for the ependymoma (EPN) and subependymoma (SubEPN). For an evidence-based review, the authors reviewed SCTs in the archives of the Seoul National University Hospital over the past decade. The frequent pathologies of primary IM-SCT were SP-EPN (45.1%), hemangioblastoma (20.0%), astrocytic tumors (17.4%, including pilocytic astrocytoma [4.6%] and diffuse midline glioma, H3 K27-altered [4.0%]), myxopapillary EPN (11.0%), and SP-subEPN (3.0%) in decreasing order. IDH-mutant astrocytomas, oligodendrogliomas, glioneuronal tumors, embryonal tumors, and germ cell tumors can occur but are extremely rare in the spinal cord. Genetic studies should support for the primary IM-SCT classification. In the 2021 WHO classifications, extramedullary SCT did not change significantly but contained several new genetically defined types of mesenchymal tumors. This article focused on primary IM-SCT for tumor frequency, age, sex difference, pathological features, and genetic abnormalities, based on a single-institute experience.
Surgical Considerations to Improve Recovery in Acute Spinal Cord Injury
Authors: Tabarestani Troy Q. , Lewis Nicholle E. , Kelly-Hedrick Margot , Zhang Nina , Cellini Brianna R. , Marrotte Eric J. , Williamson Theresa , Wang Haichen , Laskowitz Daniel T. , Faw Timothy D. , Abd-El-Barr Muhammad M.
Published: September 2022

Acute traumatic spinal cord injury (SCI) can be a devastating and costly event for individuals, their families, and the health system as a whole. Prognosis is heavily dependent on the physical extent of the injury and the severity of neurological dysfunction. If not treated urgently, individuals can suffer exacerbated secondary injury cascades that may increase tissue injury and limit recovery. Initial recognition and rapid treatment of acute SCI are vital to limiting secondary injury, reducing morbidity, and providing the best chance of functional recovery. This article aims to review the pathophysiology of SCI and the most up-to-date management of the acute traumatic SCI, specifically examining the modern approaches to surgical treatments along with the ethical limitations of research in this field.
Analisis Yuridis Terhadap Penulisan Akta Notaris Dalam Sela-Sela Kosong Buku Pendaftaran Akta
Authors: Ratna Putri Alya Regita , Yunanto Yunanto , Sukma Novira Maharani
Published: September 2022

The authority of a notary that is given to create an opportunity for a violation of the authentic deed includes recording the notary deed between deeds that have been recorded in the form of notary deed. So that the implementation of the duties of the notary office needs to be monitored. Deeds that are recorded in the spacing guidelines between notary deeds that have been recorded in the list of deeds will have the strength of evidence as deeds that do not meet formal requirements and are canceled because they contain elements of fraud. As a result, notaries must be responsible for civil sanctions, administrative sanctions and criminal sanctions. Journals are compiled using normative juridical research methods with a statutory approach. Based on the survey results, it is known that there are very dangerous consequences if the notary deed and the deed recorded within the distance between the deeds have been recorded in the notary deed register. In addition to the legal status of a deed which is reduced to a fraudulent deed and is null and void which cannot be used as perfect evidence, the deed also contradicts the obligations of notaries as stipulated in Article 15 of Law Number 2 of 2014, namely the mandatory date for notaries. ensure certainty and timing.Keywords: blank between the register of deed; deed under hand; notarial deedAbstrakPemberian kewenangan notaris guna menciptakan peluang terjadinya pelanggaran akta otentik diantarana mencatat akta notaris disela-sela akta yang telah dibukukan register akta notaris kosong. Jadi pelaksanaan tugas kantor notaris perlu dimonitor. Akta yang tercatat pada pedoman spasi antar akta notaris yang sudah dilakukan pencatatan pada daftar akta tersebut akan mempunyai kekuatan alat bukti sebagai akta yang berada di bawah akibat tidak terpenuhinya persyaratan formil dan batal karena mengandung unsur kecurangan. Akibatnya, notaris harus bertanggung jawab atas sanksi perdata, sanksi administratif, dan sanksi pidana. Jurnal disusun dengan metode penelitian yuridis normatif dengan pendekatan perundang-undangan. Berdasarkan hasil survey diketahui bahwa terdapat akibat yang sangat berbahaya jika akta notaris dan akta yang tercatat dalam pedoman spasi antar akta sudah dilakukan pencatatan pada daftar akta notaris. Sementara status hukum akta diturunkan kepada akta dibawah tangan serta batal demi hukum yang tidak bisa menjadi kesempurnaan alat pembuktian, akta itu berlawanan pada kewajiban notaris yang ditetapkan pada Pasal 15 Undang-Undang Nomor 2 Tahun 2014 yang merupakan tanggal wajib notaris. memastikan ketetapan dan waktu.Kata kunci: sela-sela kosong buku daftar akta notaris; akta di bawah tangan; akta notaris
Kewenangan Direktorat Jenderal Bea Dan Cukai Kantor Pengawasan Dan Pelayanan Bea Dan Cukai Tipe Madya Pabean Tanjung Emas Dalam Pelayanan Pengembalian Barang Tegahan
Authors: Ghassani Nadya Fairuz , Santoso Budi , Prabandari Adya Paramita
Published: September 2022

Law enforcement is absolutely necessary in order to protect the rights of the people so as to create justice for legal protection. This article discusses the mechanism for returning imported goods and the obstacles faced by customs and excise officers at the Supervision and Service Office of Customs and Excise Type Madya Tanjung Emas, Semarang City. The method used in this article is empirical juridical method, namely by conducting research in the field on the application of state administrative law, authority in the service of returned goods stored. The analysis of the research results was processed using the descriptive analysis method. In the discussion of this article, it is known that the process of preventing imported goods is carried out starting from inspection and enforcement. Furthermore, the goods are grouped into 2 types, namely goods that are auctioned off and destroyed. There are problems faced in the enforcement process, namely the lack of adequate supporting facilities and facilities, limited storage space to accommodate the goods being intercepted, requires a long process and time, and the lack of knowledge of the owners of the goods being prevented about the types of goods that can be sent into abroad through POS Indonesia.Keywords: authority; customs and excise; tegahan goodsAbstrakPenegakan hukum mutlak diperlukan guna melindungi hak-hak masyarakat sehingga tercipta keadilan perlindungan hukum. Artikel ini membahas tentang mekanisme pengembalian barang tegahan barang import dan kendala yang dihadapi oleh petugas bea dan cukai di Kantor Pengawasan dan Pelayanan Bea dan Cukai Tipe Madya Pabean Tanjung Emas Kota Semarang. Metode yang digunakan dalam artikel ini adalah yuridis empiris yaitu dengan melakukan penelitian di lapangan atas penerapan hukum administrasi negara, kewenangan dalam pelayanan pengembalian barang tegahan. Analisis hasil penelitian diolah menggunakan metode deskriptif analisis. Pembahasan artikel ini diketahui bahwa proses penegahan barang impor dilakukaan mulai dari pemeriksaan dan penegahan. Selanjutnya barang dikelompokkan menjadi 2 jenis yaitu barang yang dilelang dan dimusnahkan. Terdapat persoalan yang dihadapi dalam proses penegahan tersebut, yaitu kurangnya sarana dan fasilitas pendukung yang memadai, terbatasnya tempat penyimpanan untuk menampung barang yang ditegah, membutuhkan proses dan waktu cukup lama, dan minimnya pengetahuan pemilik barang yang ditegah tentang jenis barang yang dapat dikirim ke dalam/luar negeri melalui POS Indonesia.  kewenangan; bea dan cukai; barang tegahanKata kunci: kewenangan; bea dan cukai; barang tegahan
Eksistensi Bank Tanah Terkait Pengadaan Tanah Berdasarkan Undang-Undang Cipta Kerja
Authors: Erdiana Nila , Santoso Budi , Prasetyo Mujiono Hafidh
Published: September 2022

Regarding land sector, Job Creation Law has included regulation regarding existence of Land Banking in Indonesia. The purpose of writing this article is to examine and analyze how existence of Land Banking is related to land acquisition based on the Job Creation Law and its derivative regulations. The research method in this article is juridical normative. The existence of Land Banking related to land acquisition based on Job Creation Law includes: First, legitimacy of establishing Land Banking. Article 125 paragraph (1), (2) and (3) of the Job Creation Law states that the Central Government establishes Land Banking, which is a special agency that manages land and its assets are separated state assets. Second, structure of Land Banking organs consists of: Committee; Supervisory Board; and Implementing Agency. Third, Land Banking functions to carry out planning, acquisition, procurement, management, utilization and distribution of land. Fourth, the character of duties and authorities of Land Banking is transparent, accountable, and non-profit. Fifth, sources Land Banking assets can come from: State Budget; Own income; State equity participation; and other legitimate sources. Sixth, land managed by Land Banking is granted management rights.Keywords: Land Banking; Job Creation Law; Land AcquisitionAbstrakTerkait bidang pertanahan, UU Cipta Kerja telah menyisipkan pengaturan mengenai eksistensi Bank Tanah di Indonesia. Tujuan penulisan artikel ini adalah mengkaji dan menganalisis bagaimana eksistensi Bank Tanah terkait pengadaan tanah berdasarkan UU Cipta Kerja serta peraturan turunannya. Metode penelitian dalam artikel ini adalah yuridis normatif. Eksistensi Bank Tanah terkait pengadaan tanah berdasarkan UU Cipta Kerja meliputi: Pertama, legitimasi pembentukan Bank Tanah. Pasal 125 ayat (1), (2) dan (3) UU Cipta Kerja menyatakan bahwa Pemerintah Pusat membentuk Bank Tanah, yang merupakan badan khusus yang mengelola tanah dan kekayaannya merupakan kekayaan negara yang dipisahkan. Kedua, struktur organ Bank Tanah terdiri atas Komite, Dewan Pengawas, serta Badan Pelaksana. Ketiga, Bank Tanah berfungsi melaksanakan perencanaan, perolehan, pengadaan, pengelolaan, pemanfaatan, dan pendistribusian tanah. Keempat, sifat tugas dan wewenang dari Bank Tanah adalah transparan, akuntabel, dan non profit. Kelima, sumber kekayaan Bank Tanah dapat bersumber dari: APBN; Pendapatan sendiri; Penyertaan modal negara; dan sumber lain yang memiliki kebasahan. Keenam, tanah yang dikelola Bank Tanah diberikan hak pengelolaan.Kata kunci: Bank Tanah; UU Cipta Kerja; Pengadaan Tanah
Akibat Hukum Jual Beli Tanah Kredit Perumahan Rakyat Melalui Oper Kredit
Authors: Ramadhan Rendiyan , Sukirno Sukirno
Published: September 2022

An underhand sale and purchase agreement can harm the buyer if the seller does not have the good faith to carry out his obligations, causing a lawsuit. The problem in this journal is how the legal power of buying and selling under the hands of land and KPR-BTN buildings in the Housing Villa Intan III Blok P.7 No.7 Cirebon and what the legal consequences are for the acquisition of land rights after the District Court's decision was issued. The method used is juridical empirical. The results of this journal's research are, first, before the verdict was made, the power of law regarding buying and selling under the hands was not strong and unsafe because it did not cause the transfer of land rights, while after the Cirebon District Court decision No. then the sale and purchase under the hand is legally binding and strong, secondly, BTN must submit the certificate of land and building to the buyer to reverse the name on behalf of the buyer, who has transferred the rights to the land. The conclusion is that the judge's decision is in accordance with the exception of Article 1457 of the Civil Code as a consideration because after the existence of the UUPA, book II of the Civil Code is no longer valid and the sale and purchase relating to land uses the UUPA. Meanwhile, buying and selling in general uses Article 1457 of the Civil Code.Keywords: buying and selling; credit oper; underhandAbstrakPerjanjian jual-beli dibawah tangan dapat merugikan pihak pembeli apabila pihak penjual tidak memiliki itikad baik untuk melaksanakan kewajibannya sehingga menimbulkan gugatan. Permasalahan dalam jurnal ini yaitu bagaimana kekuatan hukum jual beli di bawah tangan tanah dan bangunan KPR-BTN di Perumahan Villa Intan III Blok P.7 No.7 Cirebon dan bagaimana akibat hukum terhadap perolehan hak atas tanah pasca putusan Pengadilan Negeri tersebut dikeluarkan. Metode yang digunakan yaitu yuridis empiris. Hasil penelitian jurnal ini yaitu pertama sebelum adanya putusan, kekuatan hukum mengenai jual-beli dibawah tangan tidak kuat dan tidak aman karena tidak menyebabkan beralihnya hak atas tanah sedangkan setelah adanya putusan PN Cirebon No.38/Pdt.G/20l6/PN.Cbn, maka jual-beli dibawah tangan tersebut adalah sah memiliki kekuatan hukum yang mengikat dan kuat, kedua yaitu BTN harus menyerahkan sertipikat tanah dan bangunan tersebut kepada pembeli untuk dibalik nama atas nama pembeli, yang telah beralih hak atas tanahnya. Simpulan bahwa keputusan hakim telah sesuai kecuali Pasal l457 KUHPerdata sebagai pertimbangan karena setelah adanya UUPA maka buku II KUHPerdata sudah tidak berlaku dan jual-beli yang berkaitan dengan tanah menggunakan UUPA. Sedangkan jual-beli secara umum menggunakan Pasal l457 KUHPerdata.Kata kunci: dibawah tangan; jual beli; oper kredit
Peran Kode Etik Notaris Dalam Membangun Integritas Notaris Di Era 4.0
Authors: Prasetyawati Betty Ivana , Prananingtyas Paramita
Published: September 2022

A Notary is a public official that has the authority to create authentic deeds and other powers as referred in Act No. 2 of 2014. In the world of notaries, the notary standards of ethics have been described in the notary code of ethics determined by the Indonesian Notary Association and must be obeyed by all notaries concerned. These codes of conduct should be the self-regulation of the profession and its implementation. The start of the industrial revolution 4.0 brought many changes to the world. Ministry of industry on a large and comprehensive scale to create a business that processes simpler, faster, easier, and cheaper to Making Indonesia 4.0 become a reality. Notaries are expected to actively participate in the licensing service process that is integrated electronically, or can be called as Online Single Submission (OSS). The urgency of reforming the code of ethics for the professional posititon of a notary as the practice of Indonesian notary in the industrial revolution 4.0 era, for the sake of creating notaries who have high integrity and morality to carry out their duties.Keywords : Notary; Code of Ethics; 4.0 Era                                                 AbstrakNotaris merupakan pejabat umum yang berwenang untuk membuat akta otentik dan kewenangan lainnya, sebagaimana dimaksud dalam Undang-Undang Nomor 2 Tahun 2014.Di dalam dunia kenotariatan standar etik Notaris telah dijabarkan dalam Kode Etik Notaris yang ditentukan oleh Ikatan Notaris Indonesia (INI) dan wajib dipatuhi oleh segenap Notaris.Kode Etik harus menjadi self-regulation dari profesi dan pelaksanaannya. Dimulainya revolusi industry 4.0 membawa banyak perubahan bagi dunia, Kementrian Perindustrian secara besar-besaran dan menyeluruh membuat business process menjadi lebih sederhana, cepat, mudah dan murah demi mewujudkan Making Indonesia 4. Para notaris diharapkan berpartisipasi aktif dalam proses pelayanan perizinan yang terintegrasi secara elektronik, atau online single submission (OSS). Urgensi pembaharuan kode etik jabatan notaris bagi praktik kenotariatan Indonesia di era 4.0 demi terciptanya notaris yang memiliki integritas dan moralitas yang tinggi dalam menjalankan tugas jabatannya.Kata Kunci : Notaris; Kode Etik; Era 4.0
Analisis Yuridis Permasalahan Pembuatan Akta Otentik Oleh Notaris/PPAT (Analisis Terhadap Putusan Nomor 210/Pid.B/2018/Pn.Smg)
Authors: Arimbi Sesaria , Handoko Widhi
Published: September 2022

The legal action of making a sale and purchase deed (AJB) must meet the requirements in the form of a photocopy of the family card, identity card, land and building tax, certificate, marriage certificate and husband and wife approval. Such conditions must be fulfilled in order for a deed to be authentic. Decision Number 210/Pid.B/2018/PN.Smg did not fulfill the presence of Tumiyem and her husband as the party entitled to the land and gave signatures in the making of the AJB made by Notary/PPAT SUGIHARTO. This research used socio-legal method by examining in depth various facts for problem solving in this research. The research specification used is descriptive analytical, data and facts obtained, then described descriptively and systematically. The data used are primary and secondary data. The absence of the parties and the not reading the deed by the Notary / PPAT in the drafting of the AJB resulted in the deed losing its authenticity and could become the basis for the claim of the injured party because there is no guarantee of legal certainty of the party entitled to the land.Keywords : authentic; deed of sale and purchase; loss.AbstrakPerbuatan hukum pembuatan akta jual beli (AJB) harus memenuhi syarat-syarat berupa foto copy KTP, KK, PBB, sertifikat, Surat Nikah dan persetujuan Suami Istri. Syarat-syarat demikian harus dipenuhi agar suatu akta dinyatakan otentik. Putusan Nomor 210/Pid.B/2018/PN.Smg ini tidak memenuhi kehadiran Tumiyem dan suaminya selaku pihak yang berhak atas tanah dan memberikan tanda tangan dalam pembuatan AJB yang dibuat oleh Notaris/PPAT SUGIHARTO.. Jenis penelitian menggunakan Socio legal research dengan cara memeriksa secara mendalam berbagai fakta untuk pemecahan masalah dalam tesis ini.  Spesifikasi penelitian  yang dipakai ialah deskriptif analitis, data dan fakta-fakta yang diperoleh, kemudian diuraikan secara deskriptif dan tersistematis. Adapun data yang digunakan yakni data primer, dan data sekunder.Ketidakhadiran pihak dan tidak dibacakannya akta oleh Notaris/PPAT dalam pembuatan AJB mengakibatkan akta kehilangan sifat otentiknya dan bisa saja menjadi dasar gugatan pihak yang dirugikan karena tidak adanya jaminan kepastian hukum pihak yang berhak atas tanah itu.Kata kunci :  otentik; akta jual beli; kerugian.
Pemecahan Sengketa Wanprestasi Melalui Gugatan Sederhana Di Pengadilan Negeri Melonguane
Authors: Hutomo Bimo Satria , Santoso Budi
Published: September 2022

The agreement or contract has a relationship and relationship with the engagement, but the obligations that must be fulfilled in an engagement are not always fulfilled, resulting wanprestasi, including bad credit which can be settled using a Small Claim Court. Small Claim Court as one of the efforts to resolve bad debts were also filed at the Pengadilan Negeri Melonguane, including the Small Claim Court No. 19 / Pdt.G.S / 2020 / PN. Mgn and Small Claim Court No. 23 / Pdt.G.S / 2020 / PN. Mgn. For this reason, this article uses normative or doctrinal research methods that only use secondary data sources such as laws and regulations, court decisions, legal theories and opinions of legal experts which are then analyzed using qualitative normative analysis which ultimately results in two things, that is: First , The Small Claim Court Mechanism at the Pengadilan Negeri Melonguane is in accordance with the provisions of PERMA 2/2015. Second, the result of the two Small Claim Court against default of bad debts is that there is peace between the parties on the first day of the trial.Keywords: dispute; wanprestasi; small claim court; Pengadilan Negeri  Melonguane.Abstrak Perjanjian atau kontrak memiliki hubungan dan keterkaitan dengan perikatan, namun kewajiban-kewajiban yang harus dipenuhi dalam suatu perikatan kenyataannya tidak selalu dipenuhi sehingga mengakibatkan wanprestasi termasuk juga dalam kredit macet yang dapat diselesaikan menggunakan Gugatan Sederhana. Gugatan sederhana sebagai salah upaya penyelesaian kredit macet juga dilakukan di Pengadilan Negeri Melonguane diantaranya Gugatan Sederhana No. 19/ Pdt.G.S/ 2020/ PN. Mgn dan Gugatan Sederhana No. 23/Pdt.G.S/2020/PN. Mgn. Atas hal tersebut, artikel ini menggunakan metode penelitian normatif atau doktrinal yang hanya menggunakan sumber data sekunder seperti peraturan perundangan, putusan pengadilan, teori-teori hukum serta pendapat para ahli hukum yang kemudian dianalisis menggunakan analisa normatif kualitatif yang akhirnya menghasilkan dua hal, yaitu: Pertama, Mekanisme Pemecahan Sengketa Gugatan Sederhana Di Pengadilan Negeri Melonguane sudah sesuai sebagaimana ketentuan PERMA 2/2015. Kedua, Hasil dari kedua gugatan sederhana terhadap wanprestasi kredit macet adalah adanya perdamaian diantara para pihak pada siding hari pertama.Kata kunci: sengketa; wanprestasi; gugatan sederhana; Pengadilan Negeri Melonguane.
Effective community search over large star-schema heterogeneous information networks
Authors: Jiang Yangqin , Fang Yixiang , Ma Chenhao , Cao Xin , Li Chunshan
Published: September 2022

Community search (CS) enables personalized community discovery and has found a wide spectrum of emerging applications such as setting up social events and friend recommendation. While CS has been extensively studied for conventional homogeneous networks, the problem for heterogeneous information networks (HINs) has received attention only recently. However, existing studies suffer from several limitations, e.g., they either require users to specify a meta-path or relational constraints, which pose great challenges to users who are not familiar with HINs. To address these limitations, in this paper, we systematically study the problem of CS over large star-schema HINs without asking users to specify these constraints; that is, given a set
Q
of query vertices with the same type, find the most-likely community from a star-schema HIN containing
Q
, in which all the vertices are with the same type and close relationships. To capture the close relationships among vertices of the community, we employ the meta-path-based core model, and maximize the number of shared meta-paths such that each of them results in a cohesive core containing
Q.
To enable efficient CS, we first develop online algorithms via exploiting the anti-monotonicity property of shared meta-paths. We further boost the efficiency by proposing a novel index and an efficient index-based algorithm with elegant pruning techniques. Extensive experiments on four real large star-schema HINs show that our solutions are effective and efficient for searching communities, and the index-based algorithm is much faster than the online algorithms.
Designing an open framework for query optimization and compilation
Authors: Jungmair Michael , Kohn André , Giceva Jana
Published: September 2022

Since its invention, data-centric code generation has been adopted for query compilation by various database systems in academia and industry. These database systems are fast but maximize performance at the expense of developer friendliness, flexibility, and extensibility. Recent advances in the field of compiler construction identified similar issues for domain-specific compilers and introduced a solution with MLIR, a generic infrastructure for domain-specific dialects.

We propose a layered query compilation stack based on MLIR with open intermediate representations that can be combined at each layer. We further propose moving query optimization into the query compiler to benefit from the existing optimization infrastructure and make cross-domain optimization viable. With LingoDB, we demonstrate that the used approach significantly decreases the implementation effort and is highly flexible and extensible. At the same time, LingoDB achieves high performance and low compilation latencies.
Don't be a tattle-tale
Authors: Pappachan Primal , Zhang Shufan , He Xi , Mehrotra Sharad
Published: September 2022

We study the problem of answering queries when (part of) the data may be sensitive and should not be leaked to the querier. Simply restricting the computation to non-sensitive part of the data may leak sensitive data through inference based on data dependencies. While inference control from data dependencies during query processing has been studied in the literature, existing solution either detect and deny queries causing leakage, or use a weak security model that only protects against exact reconstruction of the sensitive data. In this paper, we adopt a stronger security model based on
full deniability
that prevents any information about sensitive data to be inferred from query answers. We identify conditions under which full deniability can be achieved and develop an efficient algorithm that minimally hides non-sensitive cells during query processing to achieve full deniability. We experimentally show that our approach is practical and scales to increasing proportion of sensitive data, as well as, to increasing database size.
Orchestrating data placement and query execution in heterogeneous CPU-GPU DBMS
Authors: Yogatama Bobbi W. , Gong Weiwei , Yu Xiangyao
Published: September 2022

There has been a growing interest in using GPU to accelerate data analytics due to its massive parallelism and high memory bandwidth. The main constraint of using GPU for data analytics is the limited capacity of GPU memory.

Heterogeneous CPU-GPU query execution is a compelling approach to mitigate the limited GPU memory capacity and PCIe bandwidth. However, the design space of heterogeneous CPU-GPU query execution has not been fully explored. We aim to improve state-of-the-art CPU-GPU data analytics engine by optimizing
data placement
and
heterogeneous query execution.
First, we introduce a semantic-aware fine-grained caching policy which takes into account various aspects of the workload such as query semantics, data correlation, and query frequency when determining data placement between CPU and GPU. Second, we introduce a heterogeneous query executor which can fully exploit data in both CPU and GPU and coordinate query execution at a fine granularity. We integrate both solutions in Mordred, our novel hybrid CPU-GPU data analytics engine.

Evaluation on the Star Schema Benchmark shows that the semantic-aware caching policy can outperform the best traditional caching policy by up to 3x. Compared to existing GPU DBMSs, Mordred can outperform by an order of magnitude.
Tenant placement in over-subscribed database-as-a-service clusters
Authors: König Arnd Christian , Shan Yi , Ziegler Tobias , Kakaraparthy Aarati , Lang Willis , Moeller Justin , Kalhan Ajay , Narasayya Vivek
Published: September 2022

Relational cloud Database-as-a-Service offerings run on multi-tenant infrastructure consisting of clusters of nodes, with each node hosting multiple tenant databases. Such clusters may be over-subscribed to increase resource utilization and improve operational efficiency. When resources are over-subscribed, it is possible that anode has insufficient resources to satisfy the resource demands of all databases on it, making it necessary to move databases to other nodes. Such moves can significantly impact database performance and availability. Therefore, it is important to reduce the likelihood of such resource shortages through judicious placement of databases in the cluster. We propose a novel tenant placement approach that leverages historical traces of tenant resource demands to estimate the probability of resource shortages and leverages these estimates in placement. We have prototyped our techniques in the
Service Fabric
cluster manager. Experiments using production resource traces from Azure SQL DB and an evaluation on a real cluster deployment show significant improvements over the state-of-the-art.
Ginex
Authors: Park Yeonhong , Min Sunhong , Lee Jae W.
Published: September 2022

Graph Neural Networks (GNNs) are receiving a spotlight as a powerful tool that can effectively serve various inference tasks on graph structured data. As the size of real-world graphs continues to scale, the GNN training system faces a scalability challenge. Distributed training is a popular approach to address this challenge by scaling out CPU nodes. However, not much attention has been paid to
disk-based
GNN training, which can scale up the single-node system in a more cost-effective manner by leveraging high-performance storage devices like NVMe SSDs. We observe that the data movement between the main memory and the disk is the primary bottleneck in the SSD-based training system, and that the conventional GNN training pipeline is sub-optimal without taking this overhead into account. Thus, we propose Ginex, the first SSD-based GNN training system that can process billion-scale graph datasets on a single machine. Inspired by the inspector-executor execution model in compiler optimization, Ginex restructures the GNN training pipeline by separating
sample
and
gather
stages. This separation enables Ginex to realize a provably optimal replacement algorithm, known as
Belady's algorithm
, for caching feature vectors in memory, which account for the dominant portion of I/O accesses. According to our evaluation with four billion-scale graph datasets and two GNN models, Ginex achieves 2.11X higher training throughput on average (2.67X at maximum) than the SSD-extended PyTorch Geometric.
Turbo-charging SPJ query plans with learned physical join operator selections
Authors: Hertzschuch Axel , Hartmann Claudio , Habich Dirk , Lehner Wolfgang
Published: September 2022

The optimization of select-project-join (SPJ) queries entails two major challenges: (i) finding a good join order and (ii) selecting the best-fitting physical join operator for each single join within the chosen join order. Previous work mainly focuses on the computation of a good join order, but leaves open to which extent the physical join operator selection accounts for plan quality. Our analysis using different query optimizers indicates that physical join operator selection is crucial and that none of the investigated query optimizers reaches the full potential of optimal operator selections. To unlock this potential, we propose
TONIC
, a novel cardinality estimation-free extension for generic SPJ query optimizers in this paper.
TONIC
follows a
learning-based
approach and revises operator decisions for arbitrary join paths based on learned query feedback. To continuously capture and reuse optimal operator selections, we introduce a lightweight yet powerful
Query Execution Plan Synopsis
(
QEP-S
). In comparison to related work,
TONIC
enables transparent planning decisions with consistent performance improvements. Using two real-life benchmarks, we demonstrate that extending existing optimizers with
TONIC
substantially reduces query response times with a
cumulative
speedup of up to 2.8x.
Harmony
Authors: Li Youjie , Phanishayee Amar , Murray Derek , Tarnawski Jakub , Kim Nam Sung
Published: September 2022

Deep neural networks (DNNs) have grown exponentially in size over the past decade, leaving only those who have massive datacenter-based resources with the ability to develop and train such models. One of the main challenges for the long tail of researchers who might have only limited resources (e.g., a single multi-GPU server) is limited GPU memory capacity compared to model size. The problem is so acute that the memory requirement of training massive DNN models can often exceed the aggregate capacity of all available GPUs on a single server; this problem only gets worse with the trend of ever-growing model sizes. Current solutions that rely on virtualizing GPU memory (by swapping to/from CPU memory) incur excessive swapping overhead. In this paper, we present a new training framework, Harmony, and advocate rethinking how DNN frameworks schedule computation and move data to push the boundaries of training massive models efficiently on a single commodity server. Across various massive DNN models, Harmony is able to reduce swap load by up to two orders of magnitude and obtain a training throughput speedup of up to 7.6x over highly optimized baselines with virtualized memory.
Algorithm and system co-design for efficient subgraph-based graph representation learning
Authors: Yin Haoteng , Zhang Muhan , Wang Yanbang , Wang Jianguo , Li Pan
Published: September 2022

Subgraph-based graph representation learning (SGRL) has been recently proposed to deal with some fundamental challenges encountered by canonical graph neural networks (GNNs), and has demonstrated advantages in many important data science applications such as link, relation and motif prediction. However, current SGRL approaches suffer from scalability issues since they require extracting subgraphs for each training or test query. Recent solutions that scale up canonical GNNs may not apply to SGRL. Here, we propose a novel framework SUREL for scalable SGRL by co-designing the learning algorithm and its system support. SUREL adopts walk-based decomposition of subgraphs and reuses the walks to form subgraphs, which substantially reduces the redundancy of subgraph extraction and supports parallel computation. Experiments over six homogeneous, heterogeneous and higher-order graphs with millions of nodes and edges demonstrate the effectiveness and scalability of SUREL. In particular, compared to SGRL baselines, SUREL achieves 10X speed-up with comparable or even better prediction performance; while compared to canonical GNNs, SUREL achieves 50% prediction accuracy improvement.
Qanaat
Authors: Amiri Mohammad Javad , Loo Boon Thau , Agrawal Divyakant , Abbadi Amr El
Published: September 2022

Today's large-scale data management systems need to address distributed applications'
confidentiality
and
scalability
requirements among a set of collaborative enterprises. This paper presents
Qanaat
, a scalable multi-enterprise permissioned blockchain system that guarantees the confidentiality of enterprises in collaboration workflows. Qanaat presents
data collections
that enable any subset of enterprises involved in a collaboration workflow to keep their collaboration private from other enterprises. A transaction ordering scheme is also presented to enforce only the necessary and sufficient constraints on transaction order to guarantee data consistency. Furthermore, Qanaat supports data consistency across collaboration workflows where an enterprise can participate in different collaboration workflows with different sets of enterprises. Finally, Qanaat presents a suite of consensus protocols to support intra-shard and cross-shard transactions within or across enterprises.