bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterization, Potential Prognostic Value, and Immune Heterogeneity
of Cathepsin C in Diffuse Glioma
Authors: Liu Hui , Jiang Xingjun , Ren Caiping , Zhou Quanwei , Li Shasha , Yan Xuejun , Zhu Hecheng , Liu Weidong , Guo Youwei , Xu Hongjuan , Yin Wen , Li Xuewen , Yang Qian
Published: November 2022

Aims:

Diffuse glioma is the most frequent intracranial tumor and remains universally lethal. Prognostic biomarkers have remained a focus in diffuse glioma during the last decades. More reliable predictors to adequately characterize the prognosis of diffuse glioma are essential. Cathepsin C (CTSC), a lysosomal cysteine protease, is an essential component of the lysosomal hydrolase family, with their potential roles in diffuse glioma remaining to be characterized

Objective:

We aimed to investigate the performance of CTSC in predicting prognosis and therapeutic targets in diffuse glioma.

Method:

The expression profile of CTSC in multiple tumors and more than 2000 glioma samples with corresponding clinical data were collected through authoritative public databases. The expression level of CTSC was evaluated by qPCR and IHC. The prognostic value of CTSC was assessed using the univariate and multivariate cox regression analysis. The ESTIMATE R package was used to evaluate the immune and stromal scores based on the gene expression profile. The CIBERSORT was applied to evaluate the relative levels of 22 immune cell subtypes by using the R package 'CIBERSORT' to define the cell composition of tumor tissues. In addition, the MCP counter was used to assess the absolute abundance of neutrophils.

Result:

CTSC was aberrantly expressed and significantly correlated with clinical outcomes in multiple tumors. CTSC was heterogeneously expressed across histologic types and tumor grades for diffuse glioma and highly enriched in IDH or IDH1-wildtype glioma. CTSC was positively associated with immune and stromal scores and infiltrating levels of M2 macrophages and neutrophils and negatively associated with infiltrating levels of NK cells. Additionally, CTSC was closely correlated with some immune checkpoint molecules, including CD276, CD80, CD86 and PD-L2.

Conclusion:

Conclusion: CTSC was involved in shaping the immunosuppressive microenvironment and acted as an independent indicator of a poor prognosis in diffuse glioma. Targeting CTSC for glioma therapies might provide promising prospects.
Discharge of Confirmed COVID-19 Patients Based on WHO or Regional
Criteria? A Cohort Study
Authors: Ahmadpour Sajjad , Vafaeimanesh Jamshid , Adeli Seyed-Hasan , Parham Mahmoud , Asghari Akram , Bagherzade Mohammad , Shajari Rasoul , Tabarraii Reihane , Shakeri Masoumeh , Jabbari Amir , Jafari Saeede , Habibi Mohammad Amin , Khodadai Javad , Shafiee Hamed , Eskandari Narges , Dameshghi Davoud Olad , Masoumi Maryam , Ghomi Seyed Yaser Foroghi , Ebrazeh Ali
Published: November 2022

Background:

Increasing the number of COVID-19 patients raises concerns about the capacity of the health care system. This issue emphasizes reducing the admission rate and expediting patient discharge. Objective: This study aimed to develop a discharge protocol for COVID-19 patients based on the existing capacity of the healthcare system and to assess its post-discharge outcomes.

Methods:

This is a multicenter cohort study. All COVID-19 patients referred to selected medical centers in Qom, Iran, from Feb. 19 to Apr. 19, 2020, were target populations. Eligible patients were classified into a] the criterion group and b] the non-criterion group. Patients were followed up daily for 14 days after discharge by phone, and required data was gathered and recorded in follow-up form. Univariate [chi-square and t-tests] and multivariate multiple [multivariate probit regression] analysis were used.

Results:

Results: Totally, 2775 patients were included in the study [1440 people in the criterion group and 1335 people in the non-criterion group]. Based on multivariate probit regression, death was statistically associated with discharged outside our criteria [p<0.001], rising age [p<0.001], and being male [p=0.019], and readmission were associated with discharge outside our criteria [p<0.001], rising age [p=0.009], and having the history of underlying diseases [p=0.003]. Furthermore, remission had statistically significant associations with discharged based on our criteria [p<0.001], decreasing age [p=0.001], and lack of a history of underlying diseases [p<0.001].

Conclusion:

Conclusion: Mortality and readmission were significantly lower according to our discharge criteria. Our designed criteria apply to less developed and developing countries due to the limited capacity and resources available in the health care system.
Clinical and Endocrinological Responses to Different Exercise Training
Methods in Chronic Low Back Pain: A Randomized Controlled Trial
Authors: Nambi Gopal , Basuodan Reem M. , Alwhaibi Reem M. , Ebrahim Elturabi Elsayed , Verma Anju , Syed Shahanawaz , Pakkir Mohamed Shahul Hameed , Aldhafian Osama R. , Nwihadh Naif A. , Saleh Ayman K.
Published: November 2022

Aims and Background:

The knowledge about the effective implementation of different exercise training methods on clinical and endocrinological responses in soccer players with chronic low back pain (LBP) is lacking. Hence the study is proposed to find the effects of different exercise training methods on clinical and endocrinological responses in soccer players with chronic low back pain.

Methods:

Through the three-block randomization method, 60 chronic LBP participants were randomly divided into the isokinetic exercise group (IKE; n=20), ; n=20), and conventional exercise group (n=20). They received respective training for four weeks. Clinical (pain intensity & kinesiophobia) and endocrinological (glucose, insulin, HOMA-IR, growth hormone, prolactin, ACTH, and cortisol) values were measured at baseline, after 4 weeks, and at 3 months follow up.

Results:

The baseline data between the groups showed no statistical difference (p ≥ 0.05). Four
weeks following training IKE group showed significant changes in pain intensity and
kinesiophobia than CSE and conventional training groups (p < 0.05). After 4 weeks of training, all
the serum hormone variables show significant changes between the groups (glucose; p = 0.049,
insulin; p = 0.005, HOMA-IR; p = 0.021, growth hormone; p = 0.006, prolactin; p = 0.001, ACTH;
p = 0.001 and cortisol; p = 0.001). At 3 months follow up, the values for Glucose and Insulin (p >
0.05) variables did not show any statistical changes, but the rest of the variables (p = 0.001) showed
significant differences. However, the maximum improvement was seen in the IKE group as
calculated by the post hoc Tukey-Kramer’s test.

Conclusion:

Our study suggested that strength training through isokinetic exercises improved pain, kinesiophobia status, and temporary changes in serum stress hormone levels than other training methods in soccer players with chronic low back pain.
Dielectric Properties and Phase Transitions of KNO3 Embedded in Porous
Aluminum Oxide
Authors: Stukova Elena Vladimirovna , Milinskii Alexey Yurievich , Baryshnikov Sergey Vasilevich
Published: November 2022

Background:

The research of nanocomposites based on ferroelectrics has been recently stimulated
by the discovery of a number of their unique properties. These properties are of particular interest
from both fundamental and applied points of view

Objective:

This paper presents the results of comparative studies of the linear and nonlinear dielectric
properties of potassium nitrate embedded from the solution and from the melt into aluminum oxide films
with a pore diameter of 100 nm.

Methods:

An E7-25 impedance meter with a frequency range of 25 Hz – 1 MHz was used to investigate
the linear dielectric properties. The setup for researching nonlinear dielectric properties has a sinusoidal
oscillator with an operating frequency of 2 kHz.

Results:

The temperature dependences of the permittivity ε' and the third harmonic coefficient γ3ω were
measured in the heating and cooling mode. It was found that for a nanocomposite obtained from the solution,
the ferroelectric phase of KNO3 was formed only upon cooling in the temperature range 397 – 360
K. At the same time, when KNO3 was embedded into the Al2O3 film from the melt, the polar phase occurred
both upon heating and cooling in the temperature range of 300 – 432 K and 300 – 421 K, respectively.

Conclusion:

Thus, the conducted studies of the dielectric properties showed a significant difference in the
phase transition temperatures for the KNO3/Al2O3 nanocomposites obtained from the solution and from
the melt compared to the bulk sample. The phase transition shifts during heating had a different sign for
the nanocomposites obtained from the solution and from the melt. The temperature range of the existence
of the ferroelectric phase significantly depends on the method of embedding KNO3 into aluminum oxide
films. For the nanocomposite obtained from a solution, the polar phase is formed only upon cooling,
whereas when potassium nitrate is embedded from the melt, the polar phase is formed both upon heating
and cooling.
Optical Properties of Novel Materials for Optoelectronic Applications
Authors: Mudila Harish , Kataria Shivani , Kumar Anil , Prasher Parteek
Published: November 2022

Energy generation and utilization have always been a prerequisite for human society, however, in the 21st century and after the pandemic of COVID-19 situations, the importance and demand for energy storage devices have been stretched to the next level. Smart energy storage devices are required to cover this indispensable demand so that the desired energy can judiciously be delivered whenever required. For this immense effort, a variety of materials, viz. carbonaceous materials, transition metal composites, conducting polymers, etc., are being employed by the scientific community, which are equipped with advanced performance, flexibility, tunability, portability, and cost-effectiveness. Apart from these specific features, these energy harvesting materials are associated with inherent properties such as high electrical and optical conductivity, which place them as a potential contender to be used in energy harvest and storage devices. These energy storage devices can be based on the electrochemical, electrical, and optical properties of these conductive materials. To be particular, in this review, the study is targeted at optically conductive materials. The optical conductivity of a material depends upon the band gap present in the conductive material under investigation, the lower the band gap, the higher the chance of optical conductivity. This band gap of the material depends upon factors such as the material used, dopant, solvent applied, etc. This review brings the detail of optically conductive materials, understanding the factors affecting the optical conductivity and the methods to enhancing it so that the variety of applications such as solar cells, optoelectronics, photoelectronic, etc., can be improved.
Evaluation of the Antioxidant, Antidiabetic, and Anticholinesterase Potential
of Biogenic Silver Nanoparticles from Khaya grandifoliola
Authors: Akinyelu Jude , Aladetuyi Abiodun , Mbatha Londiwe Simphiwe , Oladimeji Olakunle
Published: November 2022

Introduction:

In recent years, plant-mediated synthesis of silver nanoparticles has
evolved as a promising alternative to traditional synthesis methods. In addition to producing silver
nanoparticles with diverse biomedical potential, the biosynthesis approach is known to be inexpensive,
rapid, and environmentally friendly.

Objective:

This study was aimed at synthesizing silver nanoparticles using ethanolic stem and root
bark extracts of Khaya grandifoliola and highlighting the biomedical potential of the nanoparticles
by evaluating their antioxidant, antidiabetic and anticholinesterase effects in vitro.

Methods:

Silver nanoparticles were prepared using ethanolic stem and root bark extracts of K.
grandifoliola as precursors. The biogenic silver nanoparticles were characterized using UV-visible
spectroscopy, fourier transform infrared spectroscopy, scanning electron microscopy and energydispersive
X-ray analysis. Furthermore, 2,2-Diphenyl-1-picrylhydrazyl radical scavenging, ferric
ion reducing antioxidant power, and nitric oxide scavenging assays were used to determine the
antioxidant property of the nanoparticles. The antidiabetic potential of the nanoparticles was determined
by evaluating their inhibitory effect on the activity of α-amylase and α-glucosidase. The
anticholinesterase potential of the nanoparticles was determined by assessing their inhibitory effect
on the activity of acetylcholinesterase and butyrylcholinesterase.

Results:

UV-visible spectroscopy showed surface plasmon resonance bands between 425 and 450
nm. Scanning electron microscopy revealed almost round nanoparticles with a maximum size of
91 nm. Fourier transform infrared spectroscopy affirmed the role of the phytoconstituents present
in K. grandifoliola as reducing and stabilizing agents. The biogenic silver nanoparticles showed
remarkable antioxidant, antidiabetic, and anticholinesterase effects.

Conclusion:

Biogenic silver nanoparticles could be useful in biomedical and pharmacological
applications.
Discharge Readiness Scale for Parents of High-Risk Infants: A Systematic Review
Authors: Kim Ki-Eun , Lee Hyejung , Jeon Na-Young
Published: November 2022

Purpose: Discharge readiness for parents of high-risk infants is an important predictor of successful transitions from hospital to home, however its assessments criteria require further refining in Korea. The purpose of this study is to provide a comprehensive overview of the measures available for assessing the discharge readiness for parents of high-risk infant and to evaluate the measurement properties of each instrument.Methods: A literature search for discharge readiness for parents of high-risk infants was performed using 8 electronic databases (MEDLINE, Embase, CINAHL, PsycINFO, Web of Science, KoreaMED, RISS, KISS), using preferred reporting items as per the systematic reviews guidelines. For the quality evaluations of the articles, the COSMIN checklist including content validity, internal structure, and the remaining measurement properties was used.Results: Among the 23 studies selected, 8 studies were excluded due to lack of information on their instrument’s measurement properties while remaining 15 studies were evaluated for the quality of measurement attributes. Overall information on the properties of the instruments was lacking in all studies.Conclusion: None of the instruments evaluated all the relevant measurement properties. The results of this review suggest that it is necessary to develop a discharge readiness instrument that considers the necessary and relevant characteristics required for successful hospital to home transition for parents of high-risk infants.
Breastfeeding Success Experience of Primiparas
Authors: Lee Sun Ok , Na Sung Soon , Kim Hee Sook , Bae Kyung Eui , Youn Mi Sun , Oh Eun Ju
Published: November 2022

Purpose: This study aims to describe and identify in-depth the breastfeeding experience of primiparas for more than one year using a phenomenological research method and to raise the understanding of the primiparas’ subjective experiences during the breastfeeding process to contribute to the improving and maintaining maternal and child health.Methods: This research was a phenomenological and qualitative study conducted on 5 primiparas who continued breastfeeding for more than 12 months. Data was collected through individual in-depth interviews from November 1, 2021 to March 20, 2022, and it was analyzed through the sixth stage of phenomenological research analysis presented by Colaizzi.Results: The study consisted of 10 theme clusters and 26 themes from meaningful statements about the breastfeeding success experiences of primiparas for more than one year. The 10 theme collections were "Planning breastfeeding during pregnancy," "Commitment to breastfeeding through information and education," "Challenges faced during breastfeeding," "Continuous hard work," "Continued conflict over breastfeeding amid confusion," "Connects with experts who lead the way," "Establishes one's own standards and direction," "Peace after hard work," "Solid and firm confidence," and "Deep-rooted beliefs brestfeeding serve as reminders."Conclusion: It is expected that this study will help to understand the individual difficulties and problems experienced by primiparas during breastfeeding, the importance of breastfeeding education, the role of medical personnel in the early stage of childbirth, social and environmental support, and the importance of an active window for information exchange. By identifying these factors, this study can serve as basic data for nursing practice to promote successful breastfeeding.
Influence of Fetal Attachment and Pregnancy Stress on Health Promotion Behavior in Primigravida
Authors: Yeo Soo Rueng , Choi So Young
Published: November 2022

Purpose: This study aimed to identify the effect of fetal attachment and pregnancy on health promoting behavior in primigravida.Methods: The subjects were 149 primigravidas who enrolled in nationwide online cafe for pregnant and childcare women. The data were collected from February, 2008 to February, 28 in 2022. The collected data were analyzed by IBM SPSS Statistics ver. 24.0.Results: The primigravidas’ health promoting behavior was significantly affected by the fetal attachment (β=0.37, p<0.001), spouse stress (β=0.32, p<0.001), subjective health condition (β=0.28, p<0.001), academic background (β=0.25, p<0.001), primigravidas themselves stress (β=-0.24, p=0.001), and monthly income (β=0.18, p=0.005). These variables explained 41.5% of the variance in health promoting behavior.Conclusion: It is necessary to seek out how to improve the fetal attachment through interactions with fetus, for enhancing primigravidas’ health promoting behavior and to develop a program by educational levels, for forming positive mind about health. Moreover, various efforts and strategies are required to reduce the pregnancy stress and enhance the health of both primigravidas and fetus, by early detecting and alleviating the pregnancy stress.
Association Between Female Bony Pelvimetry Using Magnetic Resonance Imaging and Cesarean Delivery due to Cephalopelvic Disproportion
Authors: Na Eun Duc , Baek Min Jung , Moon Ji Hyun , Lee Sae Mi , Lee Hanna , Yoon Jin , Jung Sang Hee , Jang Ji Hyon , Lee Ji Yeon
Published: November 2022

Purpose: To analyze the difference in bony pelvimetry using magnetic resonance imaging (MRI) in women who delivered vaginally and those who underwent cesarean section (CS) due to cephalopelvic disproportion (CPD).Methods: This retrospective case-control study enrolled Korean women who gave birth to their first child between 37 and 42 weeks of pregnancy and underwent pelvic MRI between January 2014 and June 2020. These women were classified into 3 groups: vaginal delivery (VD), CS due to CPD (CPD-CS), and CS due to reasons other than CPD (Other-CS). In MRI images, true conjugate (TC), obstetric conjugate (OC), mid anterior-posterior (AP) distance (MAD), outlet AP distance (OAD), ischial spine distance (ISD), ischial tuberosity distance (ITD), and pubic angle (PA) were measured.Results: In total, 392 women were enrolled. There were no significant differences in maternal height and body mass index at birth among the 3 groups. The ISD was statistically different between the VD group (106.2±6.4 mm) and the Other-CS group (110.4±8.8 mm) (p=0.014). After multiple regression analysis, short ISD (adjusted odds ratio [aOR], 0.92; 95% confidence interval [CI], 0.87-0.97; p=0.002), short MAD (aOR, 0.95; 95% CI, 0.89-0.99; p=0.047), and short ITD (aOR, 0.95; 95% CI, 0.91-0.99; p=0.019) were significantly associated with CS due to CPD.Conclusion: Short ISD, MAD, and ITD, measured using MRI, are important parameters that can predict CS due to CPD. The accumulation of related research could promote the development of an excellent imaging method in terms of cost-effectiveness. Thus, it may be possible to establish a method to reduce obstetric and perinatal complications due to dystonia.
Online Ethnography for People With Chronic Conditions: Scoping Review
Authors: Gao Yajing , Chen Xuemei , Zhang Wei , Wang Qiuyi , Liu Jing , Zhou Lanshou
Published: November 2022

Background

Online ethnography has been making a unique contribution to people with chronic conditions as a complement to offline ethnography. It can also be used to study the complexities and contingencies of people with chronic conditions in the context of the internet. Therefore, there is a need to synthesize existing knowledge on research activities concerning online ethnography for people with chronic conditions.

Objective

This scoping review aimed to profile the existing evidence on the application of online ethnography for people with chronic conditions, focusing on the characteristics, contributions, and implementation process. This will provide recommendations for the future use of online ethnography.

Methods

We followed the scoping review methodologies developed by Arksey and O’ Malley and the Joanna Briggs Institute. A comprehensive search was conducted on the PubMed, CINAHL, Embase, Scopus, and PsycInfo databases using preselected keywords. The search was limited to documents written in English and published between January 1, 2000, and February 1, 2022. After removal of duplicates, articles were screened by 2 independent reviewers reading the title, abstract, and full text. One reviewer extracted data, which were descriptively analyzed to map the existing knowledge.

Results

After 2836 titles and abstracts and 51 full texts were screened, 27 publications were included in the analysis, published between 2009 and 2022. Most studies were from the United States (11/27, 40.7%), and most articles collected data from online forums (10/27, 37.0%). Moreover, the most commonly used type of researcher involvement was passive analysis (24/27, 88.9%), and 18.5% (5/27) of the topics concerned people with mental illness. Notably, the majority of articles did not report the immersion process in detail (17/25, 63.0%). Ethical issues were mentioned in 88.9% (24/27) of the included articles.

Conclusions

We analyzed the current literature across fields and found that online ethnography can be exploited to explore the deeper experience of people with chronic conditions that are difficult to investigate using traditional ethnography. We found that there was diversity in researcher involvement, immersion process, data collection, and data analysis. However, most studies reported the insufficient immersion into the online environment. Researchers should determine the research approaches and data resources in order to complete culture immersion before researching. We also found that there was no uniform standard for ethical issues. Therefore, we recommend that researchers collect public and private data, obtain informed consent, and preserve the privacy and confidentiality of online users with chronic conditions. The findings can provide a practical reference for the use of online health care in studying chronic conditions.
Ten Years of Experience With a Telemedicine Platform Dedicated to Health Care Personnel: Implementation Report (Preprint)
Authors: Azzolini Claudio , Premi Elias , Donati Simone , Falco Andrea , Torreggiani Aldo , Sicurello Francesco , Baj Andreina , Azzi Lorenzo , Orro Alessandro , Porta Giovanni , Azzolini Giovanna , Sorrentino Marco , Melillo Paolo , Testa Francesco , Simonelli Francesca , Giardina Gianfranco , Paolucci Umberto
Published: November 2022

BACKGROUND

Telemedicine, a term that encompasses several applications and tasks, generally involves the remote management and treatment of patients by physicians. It is known as transversal telemedicine when practiced among health care professionals (HCPs).

OBJECTIVE

We describe the experience of implementing our telemedicine Eumeda platform for HCPs over the last 10 years.

METHODS

A web-based informatics platform was developed that had continuously updated hypertext created using advanced technology and the following features: security, data insertion, dedicated software for image analysis, and the ability to export data for statistical surveys. Customizable files called “modules” were designed and built for different fields of medicine, mainly in the ophthalmology subspecialty. Each module was used by HCPs with different authorization profiles.

RESULTS

Twelve representative modules for different projects are presented in this manuscript. These modules evolved over time, with varying degrees of interconnectivity, including the participation of a number of centers in 19 cities across Italy. The number of HCP operators involved in each single module ranged from 6 to 114 (average 21.8, SD 28.5). Data related to 2574 participants were inserted across all the modules. The average percentage of completed text/image fields in the 12 modules was 65.7%. All modules were evaluated in terms of access, acceptability, and medical efficacy. In their final evaluation, the participants judged the modules to be useful and efficient for clinical use.

CONCLUSIONS

Our results demonstrate the usefulness of the telemedicine platform for HCPs in terms of improved knowledge in medicine, patient care, scientific research, teaching, and the choice of therapies. It would be useful to start similar projects across various health care fields, considering that in the near future medicine as we know it will completely change.
Perkembangan Embrio dan Penentuan Jenis Kelamin DOC (Day-Old Chicken) Ayam Jawa Super
Authors: Kusumawati Asmarani , Febriany Rina , Hananti Shella , Dewi Mufti Sartika , Istiyawati Ninik
Published: November 2022

Super Javanese chicken is the result of a cross breeding between male domestic chicken and female layer chicken. . There has not been much research aboutSuper Javanese chicken embryonic development. This study attempts to provide information about embryonic development and sexing on Super Javanese chicken. This study used Super Javanese chicken fertile eggs from Java Farm, Maguwoharjo, Depok, Sleman. These eggs were incubated at temperature of 37o-38oC. Samples were observed with Neutral Red and Hematoxilin Eosine (HE) staining. The measurement of the Super Javanese chicken embryo were about length of the third finger, beak, and the length of the embryo's body. This observation obtained embryonic development of the super Javanese chicken spesifically. This concluded that Super Javanese chicken as a first generation from cross breeding has slower growth in embryonic development
Deteksi Gen Penyandi Sifat Resistensi Metisilin, Penisilin dan Tetrasiklin pada Isolat Staphylococcus aureus Asal Susu Mastitis Subklinis Sapi Perah
Authors: Aziz Fatkhanuddin , Lestari Fajar Budi , Nuraidah Sarah , Purwati Endah , Salasia Siti Isrina Oktavia
Published: November 2022

Detection of gene encoding resistance of bacteria could be used as an accurate method to determine resistance of Staphylococcus aureus which is causing mastitis in dairy cows to the several antibiotics. This research aimed to detect the gene encoding resistance of methicillin, penicillin and tetracycline from identified S. aureus. Sixty milk samples were collected from subclinical mastitis of cows from various dairy farming in Yogyakarta. Isolation and identification of S. aureus based on the culture, Gram staining and biochemical test. Phenotypes of S. aureus resistances against antibiotics were carried out by disc diffusion method, meanwhilespecies specific gene of S. aureus and the gene encoding methicillin, penicillin and tetracycline were confirmed by PCR method. The results showed 11 isolates representing of Methicillin Susceptible Staphylococcus aureus (MSSA) could be identified, wherein 5 isolates were harboring both of penicillin and tetracycline resistant genes respectively.
The Analysis of Amount and Various Age of Productive Female Bali Cattle that Slaughtered at Abbatoirs
Authors: Suardana I Wayan , Sukada I Made , Suada I Ketut , Widiasih Dyah Ayu
Published: November 2022

Abstract Base on the ability for surviving at the limited vegetations, bali cattle is famous  as a pioneer cattle.  Although the fertility of Bali cattle has  known   so high (up to 80%), but  the slaughter  of productive  female  of bali cattle from year to year is so high too, so that the existance of Bali cattle in the future is threatened extinct. The accurate data  indicating  the amount of Bali cattle slaughtered  at  the abbatoirs are  not available yet, exactly from the Pesanggaran and Mambal  abbatoirs as  the bigger abbatoirs in Bali.  The study used 246 heads of  Bali cattle originated from Pesanggaran, and 232 heads of  Bali cattle originated from Mambal abbatoirs, respectively. The study indicated as many as   81,7%, and 87,5% of Bali cattle slaughtered  at  those abbatoirs  were female. According to their  ages, most of them were  productive too, i.e.  99% at Pesanggaran, and 67,49% at Mambal abbatoirs, respectively. These  result  indicated  it is needed a  special attention from the Bali government exactly from the Animals Husbandry Officer in order to prevent the loss of Bali cattle populations  in the future.
Isolation, Identification and Sensitivity Test of Staphylococcus aureus against Amoxicillin of the Milk sample in the Mastitis Crossbred Ettawa Goat at Girimulyo Area, Kulon Progo, Yogyakarta
Authors: Dewi Amalia Krishna
Published: November 2022

Staphylococcus aureus is the main bacteria causing mastitis of the Ettawa crossbreed goat. The mastitis causes significant economic losses due to decreasing of milk production. Mastitis in goat could threat the survival rate of her kids because decrease in quality and quantity of milk products. The toxin produced by S.aureus can also cause the death of their mothers. The present research is aimed to isolate and identify S. aureus from mastitis milk sample of Ettawa crossbreed goat, and does its sensitivity to amoxicillin as well. The milk samples were collected from the mastitis crossbreed Ettawa goat at Girimulyo area, Kulonprogo, Yogyakarta. In the present study, 20 milk samples of Ettawa crossbreed goat were used to isolate and identify S. aureus based on the culture, Gram staining, biochemical and sugar tests. The isolates then tested for their sensitivity to amoxicillin. Nine isolates in the present study identified as S. aureus in which they grew on MSA, formed round cells cluster, Gram +, fermented manitol, lactose and maltose. They coagulated the rabbit plasma and reacted positively to the clumping factor and Voges Proskouer test. Based on the results of the sensitivity test to 10 ìg amoxicillin is known that 8 isolates (88,89%) are sensitive to amoxicillin. Therefore, it can be concluded that there are 9 isolates from 20 mastitis milk samples of Ettawa crossbreed goat identified as S. aureus. Staphylococcus aureus isolates are mostly sensitive to amoxicillin.
Imagining the Sun: using comparative judgement to assess the impact of cross-curricular solar physics workshops
Authors: Davenport Carol , Morton Richard
Published: November 2022

This paper describes a school intervention focused on visual art and solar physics using science capital and STEAM methodologies to develop STEM engagement activities. Data from 40 children (aged 8–11) in two primary schools in the North East of England are presented, using pre- and post-intervention surveys which contained free-response and likert-scale questions. The paper presents a novel, and transferable, method of evaluating children’s drawings using online comparative judgement marking software, particularly suited to those without a background in qualitative research. Using comparative judgement this paper shows that the intervention led to a moderate increase in girls’ knowledge of solar physics.
Experimental and theoretical investigation of the formation of the surface layer highly alloyed with aluminum
Authors: Mozhayko A. A. , Gerashchenkov D. A. , Staritsyn M. V.
Published: November 2022

Laser surface treatment is a complex process in which, under the influence of a laser, the surface of material melts, while changing its structure and properties. In this paper, we consider the simulation of the process and present the results of studying the influence of laser processing parameters on the dimensions of the melt pool. The main purpose of the study is to reveal the dependence of the depth of the melt pool, namely the thickness of the layer in which the mixing process of the components takes place, on the laser parameters. As a result of the study, it was found that after laser treatment of the surface of samples with a coating thickness of 20, 40 and 80 μm at a beam speed of 100 mm/s and power of 180 W, the coating material is completely mixed with the substrate. It is also shown that with the laser travel speed 400 and 800 mm/s and the power 180 W, there is no mixing of the components in the impact zone, since the energy input is not enough.
Features of the behavior of the dispersion fuel METMET under irradiation
Authors: Karpyuk L. A. , Savchenko A. M. , Konovalov Yu. V. , Kulakov G. A. , Maranchak S. V. , Ershov S. A. , Maynikov E. V. , Kozlov A. V. , Izhutov A. L. , Shishin V. Y. , Sheldyakov A. A. , Yakovlev V. V.
Published: November 2022

The paper considers the behavior under irradiation of the METMET fuel composition, which consists of particles of uranium-molybdenum alloy in a matrix of zirconium alloys. Post-reactor investigations confirmed the satisfactory performance of pilot fuel elements irradiated in the MIR reactor to a burnup of 61 MW day/kgU under significant thermal loads. The structural stability of the fuel under irradiation, good compatibility of the fuel rod components with each other could be noted. Fuel rods with METMET fuel composition have good prospects for use in reactors of floating nuclear power units and low-capacity nuclear plants, as well as a tolerant fuel.
Нелинейный анализ изгиба пластин из слоистого композита с использованием уточненной зигзагообразной теории
Authors:   Department of Mechanical Engineering, Faculty of Engineering, Arak University, Хошгофтар М. Дж. , Карими М. , Сейфури С. ,   Department of Mechanical Engineering, Faculty of Engineering, Vali-e-Asr University of Rafsanjan
Published: November 2022

Для исследования изгибного поведения композитных пластин и сандвич-конструкций использована модифицированная зигзагообразная теория, основанная на теории сдвигового деформирования первого порядка для некоторых кусочно-линейных функций перемещений в плоскости. Эта теория не зависит от коэффициента коррекции на сдвиг и может быть применена к разным инженерным задачам, связанным с динамикой конструкций. Для получения точных результатов при больших деформациях в уравнении совместности фон Кармана учтены члены нелинейной деформации. Определяющие уравнения и связанные с ними граничные условия получены с помощью принципа виртуальной работы. Численные результаты сопоставлены с результатами других теорий и установлено их превосходное согласование. Результаты, представленные графически и таблично, иллюстрируют превосходство рассмотренной модели при предсказании полей напряжений и перемещений. Предложенная модель применима к нелинейным задачам с большими прогибами.
Нелинейный анализ механического поведения балок из функционально-градиентного сплава с памятью формы
Authors:   School of Science, Lanzhou University of Technology, Ян Цз. , Тан Цз. , Ван Ю. , Ван Ц.
Published: November 2022

С использованием теории изгиба балок и соотношений между напряжениями и деформациями для материалов из сплавов с памятью формы проанализировали нелинейное механическое поведение балок из функционально-градиентных сплавов с памятью формы, подверженных нечистому изгибу. Предположили, что объемное содержание сплава изменяется по толщине балки по закону степенной функции. Распределение напряжений в её поперечном сечении на каждой стадии фазового преобразования определили путем введения коэффициента асимметрии растяжения–сжатия. Перемещение нейтральной оси балки, кривизну поперечного сечения и изменение границы раздела фаз в осевом направлении рассчитали путем решения уравнения равновесия. Результаты показали, что влияние изменения показателя степени на асимметрию растяжения–сжатия намного больше, чем изменение коэффициента асимметрии растяжения–сжатия. Перемещение нейтральной оси и кривизна поперечного сечения нелинейно отрицательно связаны с показателем степени. С увеличением показателя степени граница фазового преобразования смещалась ближе к срединному сечению. Перемещение нейтральной оси того же поперечного сечения нелинейно положительно связано с коэффициентом асимметрии растяжения–сжатия, а кривизна – нелинейно отрицательно. Фазовая граница на сжатой стороне балки смещалась ближе к срединному сечению по мере увеличения коэффициента асимметрии растяжения– сжатия. Результаты расчетов могут быть использованы в качестве ориентира при разработке и применении таких материалов.
Evaluation of Pharmacological Profiling of Albizia Odoratissima Bark Extracts on Ethanol-Induced Hepatotoxicity in Albino Rats
Authors: Jayachandrababu Byna , Rajaram S , Gupatha Bayya M H R K , Singh Goverdhan , R Zaveri Jitendra
Published: November 2022

Alcohol consumption is a common cause of acute and chronic hepatic toxicity in patients. Discovery of novel therapeutic agents from medicinal plants is most recommended because of the presence of diverse phytochemicals. The aim of the study is to evaluate the therapeutic effect of methanolic extract of bark of Albizia odoratissima on ethanol-induced hepatotoxicity in rats. The following objectives A. odoratissima bark extract was screened for phytochemical analysis, and tests on acute toxicity and hepatoprotection using an Albino rat model were conducted. Twenty-four male albino rats were selected and divided into four groups (n=6). Animals received treatments for a period of 21 days. Normal control (Group-I) received vehicles; toxic control (Group-II) received ethanol (2 ml/kg/p.o.). Treatment groups (Groups-III and IV) received Silymarin (50 mg/kg/p.o.) and plant extract (250 mg/kg/p.o.). Biochemical parameters such as hepatic enzymes, biomarkers and histopathology were estimated to assess the severity of hepatic injury and or disease. Phytochemical analysis of extract reported the presence of secondary metabolites. Ethanol significantly increased SGPT and SGOT, ALP, TB, urea, and creatinine and significantly decreased total protein and albumin levels, indicating hepatic damage. Silymarin ameliorates all hepatic enzymes and biomarkers as compared to hepatotoxic control. Meanwhile, methanolic extract significantly decreased only SGPT, ALP, and creatinine, compared to hepatotoxic control. Histopathological examinations of silymarin and A. odoratissima revealed reduced liver inflammation. This study concludes that a 250mg/kg dose of A. odoratissima showed partial protective effects on ethanol-induced hepatotoxicity in rats as compared with silymarin.Â
Dünden Bugüne Beyşehir Gölü (Isparta-Konya, Türkiye) Balıkçılığı ve Durum Analizi
Authors: Gülle İskender , Küçük Fahrettin , Güçlü Salim Serkan
Published: November 2022

Anadolu plakasının önemli karstik boşalım havzalarından birinde yer alan Beyşehir Gölü 650 km2 yüzey alanı ile Türkiye’nin en büyük tatlısu gölü olmasının yanında; biyo-ekolojik, sosyo-ekonomik ve kültürel yönlerden çok önemli bir sulak alandır. Beyşehir Gölü balıkçılığı üzerine tutulmuş ilk kayıtlar 1910’lara dayanmakla birlikte, balıkçılığa ait ilk bilimsel bulgular 1950’li yıllarda başlamıştır. Gölün balıkçılığı hakkında güvenli verilere ulaşmak oldukça zor olmakla beraber, 1950’lerden günümüze kadar olan süreçte balıkçılık üzerine etkin olan başlıca süreçlerin: i) kullanılan avcılık yöntemi ve av araçları, ii) gölün trofik yapısındaki değişimler, iii) yabancı fauna elemanlarının göle girmesi, iv) gölün su seviyesindeki değişimler, v) balıkçıların sosyo-ekonomik ve bilinç düzeyi, vi) balıkçılık yönetim stratejileri olduğu görülmüştür. Gölde 1950’lerde yaklaşık 3 kg/ha olan av verimi 2021 yılında 13,34 kg/ha olarak belirlenmiştir. Aradan geçen zamanda faunada önemli değişimler olurken, artan av miktarı ile birlikte balıkçı sayısında da önemli bir artış olduğu belirlenmiştir. Günümüzde 14’ü endemik olmak üzere 23 balık türünün yaşadığı ve mezotrofik-ötrofik düzeyde olan gölde, 2010-2021 yılları ortalamasına göre avlanan 669.051 kg balığın %67,41’ini Carassius gibelio (gümüşi havuzbalığı) %20,17’sini Sander lucioperca (sudak) ve %12,42’sini Cyprinus carpio (sazan) oluştururken; 2021 yılındaki avcılık dağılımının ise %75,41’ini gümüşi havuzbalığı, %21,47’sini sudak ve %3,11 kadarını ise sazan oluşturmuştur. Gölde 385 adet balıkçı aktif olarak avcılık yapmakta olup, 2021 yılı verilerine göre balıkçı başına 2.252 kg/yıl ava karşılık 13.790 TL/yıl kazanç elde edilmiştir. Bu çalışmanın diğer bir sonucu olarak, Beyşehir Gölü balıkçılık ekosistemi üzerindeki en büyük etkenin zamansız ve aşırı avcılık olduğu anlaşılmıştır.
Responsabilidad profesional en el ejercicio de la enfermería argentina. Hacia la construccion de una cultura preventiva y no punitiva
Authors: Palacio José María
Published: November 2022

En el marco del ejercicio profesional, el enfermero interactúa con otros profesionales dentro del ecosistema sanitario dispensando servicios de salud al paciente, familia y comunidad durante el curso de vida, a su vez en este entramado muchas veces acaecen actos médicos antijuridicos y/o negligentes que enmarcan el instituto de Responsabilidad profesional independientemente de la esfera administrativa, civil y penal. En un escenario donde la judicialización de la medicina, Enfermería ha superado las barreras administrativas, llegando a la última ratio, es necesario el tratamiento y abordaje de este fenómeno desde los basamentos teóricos de la disciplina, doctrinarios y jurisprudenciales, para la consecuente reflexión y desarrollo de políticas de prevención de riesgos basados en una cultura amigable preventiva y no punitiva.
Diagnosis and Treatment of Multiorgan-Penetrating Injuries to the Head and Neck: Case Series
Authors: Wang Junxin , Wang Yan , Xu Cong , Li Guangjin , Wang Chen , Mou Yakui , Chen Xiumei , Song Xicheng , Sun Yan
Published: November 2022

Multiorgan-penetrating injuries to the head and neck are relatively
uncommon, with many complications and high mortality, and the management
of such injuries is often complex and nonstandardized. Here, we report
our experience of treating such injuries. We retrospectively analyzed
multiorgan-penetrating injuries to the head and neck in patients who
were admitted to and managed in our department. We evaluated first-aid
measures, imaging examination findings, operation method, and prognoses.
A total of 5 patients were identified. The patients were successfully
treated; two of these patients with wooden foreign bodies underwent
digital subtraction angiography (DSA) of the common carotid artery. To
sum up, we conclude that individualized multidisciplinary treatment
according to the affected organs and manner of impalement can greatly
reduce intraoperative and postoperative complications. In
endoscopy-assisted removal with irregular wooden foreign bodies, we
advocate intraoperative DSA of common carotid arteries as a routine
procedure.
“A Process-Based Approach to Conflicts of Interest”
Authors: Birnkrant David , Black Jane , Carter John
Published: November 2022

The current system for disclosing financial conflicts of interest (COIs)
can be traced back to the “Uniform requirements for manuscripts
submitted to medical journals,” published in 1997. Meanwhile, new
molecular and genetic therapies are transforming clinical medicine and
these therapies have radically altered the financial landscape of drug
development. The average price of new drugs has risen sharply, and in
niche areas like rare diseases, the cost of new therapies can be
stratospheric. Now, even rare or “orphan” diseases are funded by
private investment. With high profitability, there is a new
pathway for drug development involving unprecedented ties between
industry and academia. The potential for COIs has greatly expanded and
decisions that were once science-driven have become profit-driven. As a
result, the risk that marginally effective, ineffective and even
hazardous treatments will make their way to patients has greatly
increased. In this editorial, we propose a system built on
process-based COIs. This new system would trace the developmental
journey of a drug from the lab to patients. All financial ties that
institutions and individuals have to the drug would be disclosed at each
developmental step. The goal would be to create a healthy skepticism and
debate over the studies behind new drugs, restoring a scientific focus
to the assessment of drug efficacy. When society’s limited resources are
used to pay for drugs whose excessive cost primarily benefits investors
and corporations, it derails scientific objectivity, harms patients, and
threatens the financial stability of our health care systems.
Pre-traction-assisted endoscopic submucosal dissection of a rectal neuroendocrine tumor
Authors: Lu Qin , Liu Wei-Hui
Published: November 2022

Conventional ESD may not ensure complete resection of submucosal tumors,
as the dissecting layer behind the tumor is difficult to see. To conquer
this dilemma, we present a novel pre-traction strategy using clips and
rubber-band, which facilitate ESD removal of rectal NETs.
An Option-Based Approach to Measuring Disclosure Asymmetry
Authors: Smith Kevin C.
Published: November 2022

In this paper, I develop a measure of the difference in the amount of information that investors expect a forthcoming disclosure to contain should it reveal good news versus bad news (the disclosure’s “asymmetry”). To do so, I first show that this asymmetry is linked to the skewness of returns that the disclosure creates. I then show that this skewness can be measured using a weighted change in option-implied return skewness leading up to the disclosure’s release. The measure’s ability to capture investors’ prior beliefs regarding asymmetry is advantageous when studying ex ante decisions including contracting and information acquisition choices. I implement it on a sample of large firms’ quarterly earnings announcements, finding evidence that investors anticipate cross-sectional but not time-series variation in earnings’ asymmetry.
Can Shareholders Benefit from Consumer Protection Disclosure Mandates? Evidence from Data Breach Disclosure Laws
Authors: Ashraf Musaib , Sunder Jayanthi
Published: November 2022

Data breach disclosure laws are state-level disclosure mandates intended to protect individuals from the consequences of identity theft. However, we argue that the laws help reduce shareholder risk by encouraging managers to take real actions to reduce firms’ exposure to cyber risk. Consistent with this argument, we find an on-average decrease in shareholder risk, proxied by cost of equity, after the staggered passage of these laws. We also find the effect is attenuated for firms that already took real actions to manage cyber risk before the laws. Further, after these laws, firms are more likely to increase cybersecurity investments and have a cybersecurity officer. Finally, we observe positive abnormal returns on key dates related to the passage of these laws. Our collective evidence suggests that consumer protection disclosure mandates can benefit shareholders and, specifically, that regulators can use disclosure mandates to incentivize managers to reduce firms’ exposure to cyber risk.

Data Availability: All data used in this study are publicly available.

JEL Classifications: G120; G340.