bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of a Medicare Health Outcomes Survey Deficit-Accumulation Frailty Index and Its Application to Older Patients With Newly Diagnosed Multiple Myeloma
Authors: Mian Hira S. , Wildes Tanya M. , Fiala Mark A.
Published: July 2018

Purpose

To develop a frailty index using the Rockwood Accumulation of Deficits approach for the Medicare Health Outcomes Survey (MHOS) and apply it in a subset of older patients with newly diagnosed multiple myeloma.

Methods

Data from 2,692,361 patients without cancer, > 66 years of age, in SEER-MHOS linked databases between 1998 and 2009 were analyzed. A frailty index was constructed, resulting in a 25-item scale; cutoff values were created for individuals classified as frail. This frailty index was then applied to 305 patients with newly diagnosed myeloma in the database to predict overall survival.

Results

In the derivation cohort of patients without cancer, the median age was 74 years and the mean frailty index was 0.23 (standard deviation, 0.17). Among patients without cancer, each 10% increase in frailty index (approximately three to four more deficits) was associated with a 40% increased risk for death (adjusted hazard ratio, 1.397; 95% CI, 1.396 to 1.399; P < .001). In the cohort of patients with newly diagnosed myeloma, the median age was 76 years and the mean frailty index was 0.28 (standard deviation, 0.17). Each 10% increase in frailty index was associated with a 16% increased risk for death (adjusted hazard ratio, 1.159; 95% CI, 1.080 to 1.244; P < .001). Fifty-three percent of patients with multiple myeloma were considered frail. The estimated median overall survival of patients considered frail was 26.8 months, compared with 43.7 months ( P = .015) for those who were not.

Conclusion

The MHOS-based frailty index was prognostic for patients with multiple myeloma in predicting overall survival.
Contemporarily Treated Patients With Hodgkin Lymphoma Have Childbearing Potential in Line With Matched Comparators
Authors: Weibull Caroline E. , Johansson Anna L.V. , Eloranta Sandra , Smedby Karin E. , Björkholm Magnus , Lambert Paul C. , Dickman Paul W. , Glimelius Ingrid
Published: July 2018

Purpose

With excellent cure rates for young patients with Hodgkin lymphoma (HL), there is an increasing number of female survivors of HL interested in becoming pregnant. Here, we report childbearing among contemporarily treated HL survivors in comparison with the general population.

Material and Methods

Using Swedish registers, 449 women (ages 18 to 40 years) diagnosed with HL between 1992 and 2009 and in remission 9 months after diagnosis were identified. Patients were age- and calendar-year–matched to 2,210 population comparators. Rates of first postdiagnosis childbirth were calculated. Hazard ratios (HRs) with 95% CIs were estimated for different follow-up periods using Cox regression. Cumulative probabilities of first childbirth were calculated in the presence of the competing risk of death or relapse.

Results

Twenty-two percent of relapse-free patients with HL had a child during follow-up, and first childbirth rates increased over time, from 40.2 per 1,000 person-years (1992 to 1997) to 69.7 per 1,000 person-years (2004 to 2009). For comparators, childbirth rates remained stable (70.1 per 1,000 person-years). Patients diagnosed between 2004 and 2009 had a cumulative probability of childbirth similar to comparators. Three years or more after diagnosis, no differences in childbirth rates were observed between patients and comparators, regardless of stage or treatment. Patients who received six to eight courses of bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone had a lower childbirth rate than comparators during the first 3 years (HR, 0.23; 95% CI, 0.06 to 0.94), as did patients who received six to eight courses of chemotherapy and radiotherapy (HR, 0.21; 95% CI, 0.07 to 0.65).

Conclusion

Childbearing potential among female survivors of HL has improved over time, and childbirth rates 3 years after diagnosis in contemporarily treated patients are, in the absence of relapse, similar to those in the general population, regardless of stage and treatment.
Prospective Study of Psychosocial Outcomes of Having Contralateral Prophylactic Mastectomy Among Women With Nonhereditary Breast Cancer
Authors: Parker Patricia A. , Peterson Susan K. , Shen Yu , Bedrosian Isabelle , Black Dalliah M. , Thompson Alastair M. , Nelson Jonathan C. , DeSnyder Sarah M. , Cook Robert L. , Hunt Kelly K. , Volk Robert J. , Cantor Scott B. , Dong Wenli , Brewster Abenaa M.
Published: July 2018

Purpose

The incidence of contralateral prophylactic mastectomy (CPM) has continued to increase. We prospectively examined psychosocial outcomes before and up to 18 months after surgery in women who did or did not have CPM.

Methods

Women with unilateral, nonhereditary breast cancer completed questionnaires before and 1, 6, 12, and 18 months after surgery. Primary psychosocial measures were cancer worry and cancer-specific distress. Secondary measures were body image, quality of life (QOL), decisional satisfaction, and decisional regret.

Results

A total of 288 women (mean age, 56 years; 58% non-Hispanic white) provided questionnaire data, of whom 50 underwent CPM. Before surgery, women who subsequently received CPM had higher cancer distress ( P = .04), cancer worry ( P < .001), and body image concerns ( P < .001) than women who did not have CPM. In a multivariable repeated measures model adjusted for time, age, race/ethnicity, and stage, CPM was associated with more body image distress ( P < .001) and poorer QOL ( P = .02). There was a significant interaction between time point and CPM group for cancer worry ( Pinteraction < .001), suggesting that CPM patients had higher presurgery cancer worry, but their postsurgery worry decreased over time and was similar to the worry of patients who did not have CPM. QOL was similar between CPM groups before surgery but declined 1 month after surgery and remained lower than patients who did not have CPM after surgery ( Pinteraction = .05).

Conclusion

These results may facilitate informed discussions between women and their physicians regarding CPM. Fear and worry may be foremost concerns at the time surgical decisions are made, when women may not anticipate the adverse future effect of CPM on body image and QOL.
Mild Hypothyroidism in Childhood: Who, When, and How Should Be Treated?
Authors: Vigone Maria Cristina , Capalbo Donatella , Weber Giovanna , Salerno Mariacarolina
Published: July 2018

Mild hypothyroidism, also known as subclinical hypothyroidism (SH), is biochemically defined as serum TSH levels above the upper limit of the reference range, in the presence of normal serum concentrations of total T4 and free T4 (FT4). In the neonatal period, mild hypothyroidism can be defined by the presence of a TSH value between 6 and 20 mIU/L and normal FT4 levels. After the neonatal period, SH can be defined mild if TSH ranges between 4.5 and 10 mIU/L. The management of mild hypothyroidism in childhood is challenging. The major concern is to establish whether this condition should always be considered an expression of mild thyroid dysfunction. Indeed, the effects of untreated mild hypothyroidism are still not completely defined. In the neonatal period, concern exists about neurocognitive outcome; in children, although there is no clear evidence of alterations in growth or neurocognitive development, subtle cardiovascular abnormalities have been documented. Therefore, there is still uncertainty about the need of treatment across all ages, and the management should be based on the age of the child, the etiology, and the degree of TSH elevation, as well as on other patient factors. This review updates current evidences on diagnosis and management of mild hypothyroidism in childhood.
Rebel Coolies, Citizen Warriors, and Sworn Brothers: The Chinese Loyalty Oath and Alliance with Chile in the War of the Pacific
Authors: Tinsman Heidi
Published: July 2018

This essay interprets Chilean accounts of a loyalty oath by Chinese coolies to the Chilean army during the War of the Pacific against a broader social history of Chinese agrarian resistance in Peru and military experience in China. The essay argues that masculinity and labor were central to articulating divergent political agendas and defining national differences as racial differences. Chilean tales about emancipating Chinese slaves affirmed Chile's superiority over despotic Peruvians. Moreover, in stories about a Chinese oath, Chileans affirmed their civilizing mission by recognizing Chinese men as similar to themselves: brave warriors prepared to die for freedom and nation. For Chinese men, the oath was not about loyalty to Chile but loyalty to each other in an ongoing fight against bondage on Peruvian plantations. The ceremony enacted a Chinese fraternity of mutual protection and hierarchy that helped leverage Chile's invasion to replace coolie arrangements with Chinese-controlled subcontracting and free peonage.
Endogenous Disasters
Authors: Petrosky-Nadeau Nicolas , Zhang Lu , Kuehn Lars-Alexander
Published: July 2018

Market economies are intrinsically unstable. The standard search model of equilibrium unemployment, once solved accurately with a globally nonlinear algorithm, gives rise endogenously to rare disasters. Intuitively, in the presence of cumulatively large negative shocks, inertial wages remain relatively high, and reduce profits. The marginal costs of hiring run into downward rigidity, which stems from the trading externality of the matching process, and fail to decline relative to profits. Inertial wages and rigid hiring costs combine to stifle job creation flows, depressing the economy into disasters. The disaster dynamics are robust to extensions to home production, capital accumulation, and recursive utility. (JEL E22, E23, E24, E32, J41, J63, N12)
Firms, Informality, and Development: Theory and Evidence from Brazil
Authors: Ulyssea Gabriel
Published: July 2018

This paper develops and estimates an equilibrium model where heterogeneous firms can exploit two margins of informality: (i) not register their business, the extensive margin; and (ii) hire workers “off the books,” the intensive margin. The model encompasses the main competing frameworks for understanding informality and provides a natural setting to infer their empirical relevance. The counterfactual analysis shows that once the intensive margin is accounted for, firm and labor informality need not move in the same direction as a result of policy changes. Lower informality can be, but is not necessarily associated with higher output, TFP, or welfare. (JEL D22, E26, H26, J46, O14, O17)
Violence and Risk Preference: Experimental Evidence from Afghanistan: Comment
Authors: Vieider Ferdinand M.
Published: July 2018

In this comment on Callen et al. (2014), I revisit recent evidence uncovering a “preference for certainty” in violation of dominant normative and descriptive theories of decision-making under risk. I show that the empirical findings are potentially confounded by systematic noise. I then develop choice lists that allow me to disentangle these different explanations. Experimental results obtained with these lists reject explanations based on a preference for certainty in favor of explanations based on random choice. From a theoretical point of view, the levels of risk aversion detected in the choice list involving certainty can be accounted for by prospect theory through reference dependence activated by salient outcomes. (JEL C91, D12, D74, D81, O12, O17)
From Final Goods to Inputs: The Protectionist Effect of Rules of Origin
Authors: Conconi Paola , García-Santana Manuel , Puccio Laura , Venturini Roberto
Published: July 2018

Recent decades have witnessed a surge of trade in intermediate goods and a proliferation of free trade agreements (FTAs). FTAs use rules of origin (RoO) to distinguish goods originating from member countries from those originating from third countries. We focus on the North American Free Trade Agreement (NAFTA), the world’s largest FTA, and construct a unique dataset that allows us to map the input-output linkages in its RoO. Exploiting cross-product and cross-country variation in treatment over time, we show that NAFTA RoO led to a sizable reduction in imports of intermediate goods from third countries relative to NAFTA partners. (JEL F13, F15, F23, L14, O19)
Os acordos substitutivos e o termo de ajustamento de conduta (Lei nº 7.347/1985)
Authors: Kato Mariana Almeida
Published: July 2018

Administrative arrangements and the adjustment of conduct agreement (Law 7.347/1985) O termo de ajustamento de conduta previsto pela Lei nº 7.347/1985 tem assumido especial importância na proteção de interesses difusos, no qual se destaca o meio ambiente. Dada ausência de tratamento normativo mais específico e da necessidade de pensar o direito administrativo para além das fronteiras tradicionalmente existentes, o tema ainda suscita dúvidas e debates quanto ao seu alcance, formação e limites. The adjustment of conduct agreement provided in Law 7.347/1985 has become especially important in the protection of diffuse interests, which environment plays a major role. Due to the absence of more specific legislation and the necessity of rethinking the administrative law beyond the traditionally existing borders, the subjects still raises doubts and discussions about its scope, formation and limits.
Partilha de produção petrolífera: reflexões sobre a nova reforma
Authors: Leite Marcelo Lauar
Published: July 2018

Petroleum production sharing: thinking about the new reform Este ensaio se propõe a apresentar reflexões sobre o status e as perspectivas do sistema não concorrencial da “partilha de produção” após a reforma regulatória ocorrida em 2016. De fato, embora o regime jurídico ao qual se sujeitam os agentes econômicos atuantes no desenvolvimento de campos em áreas de pré-sal não seja propriamente inseguro, é também certo que ele não pode ser chamado de estável. Com efeito, apenas uma década após a descoberta do pré-sal, a tutela jurídica de sua exploração já foi alvo de três diplomas de peso: as Leis Federais nos 9.478/1997 (Lei do Petróleo — LP), 12.351/2010 (Lei da Partilha de Produção — LPP) e, mais recentemente, a 13.365/2016. Com esta última, os regimes estabelecidos na LP e na LPP ganharam novidades de relevante repercussão prática no âmbito da regulação estatal sobre a exploração do pré-sal, destacadamente no que tange ao papel da Petrobras. Neste trabalho, pretende-se contribuir com o debate a respeito das alterações vigentes ao final de 2016, relacionando, as aos sistemas concorrencial e de partilha de produção e antevendo resultados prospectivos de interesse para a indústria do petróleo e gás natural. This essay proposes to reflect on the status and prospects of the noncompetitive system of “production sharing” after the regulatory reform in 2016. In fact, although the regulation of the economic agents involved in the development of fields in pre-salt areas is not properly insecure, it is also certain that it cannot be called stable. Indeed, only a decade after the discovery of the pre-salt, the legal protection of its exploration has already been the subject of three important Federal Laws: 9.478/1997 (LP), 12.351/2010 (LPP) and, more recently, 13.365/2016. With the latter, the regimes established in the LP and in the LPP gained novelties of relevant practical repercussion in the scope of the state regulation on the exploration of the pre-salt, especially on the Petrobras function. In this paper, we intend to contribute to the debate about the legal changes made at the end of 2016, relating them to the competitive and production sharing systems and anticipating prospective results of interest to the Oil and Natural Gas Industry.
Corrupção e compliance nas empresas públicas e sociedades de economia mista: racionalidade das disposições da Lei de Empresas Estatais (Lei nº 13.303/2016)
Authors: Pinho Clóvis Alberto Bertolini de , Ribeiro Marcia Carla Pereira
Published: July 2018

Corruption and compliance in state-owned companies: rationality of the Brazilian State Owned Companies Law (13.303/2016) A Lei nº 13.303/2016, Lei das Empresas Estatais, disciplinou diversos pontos lacunosos no direito brasileiro, nomeadamente a disciplina jurídica das sociedades de economia mista e empresas públicas. Um desses pontos é a obrigatoriedade da existência de políticas de compliance e governança corporativa para as empresas estatais, com a vedação expressa da possibilidade de acontecimentos de atos de corrupção (art. 9º, §1º, I, da Lei nº 13.303/2016). A previsão revela a particularidade com que vem sendo tratado o combate à corrupção no Brasil, principalmente no âmbito das empresas estatais. Por outro lado, a Lei nº 13.303/2016 inaugura exigências que até então eram praticadas no mercado privado e no exterior, como a constituição de Comitês de Auditoria Externos, ligados diretamente aos Conselhos de Administração das sociedades de economia mista e empresas públicas (desde que adotem o regime das sociedades anônimas). Adotando o método da análise econômica do direito, o presente artigo aborda como o fenômeno da corrupção pode afetar o funcionamento das empresas estatais brasileiras. The Brazilian Law Nº 13.303/2016 has disciplined a number of shortcomings about the State-Owned Companies in the Brazilian legal system, namely the legal discipline of mixed-capital companies and public companies. One of these points is the obligation that State-Owned Companies must have compliance and corporate governance policies, with the express prohibition of events involving acts of corruption (article 9, §1º, I, of Law 13303/2016). The Law Nº. 13.303/2016 reveals the particularity with which the fight against corruption in Brazil has been addressed. The Brazilian Law Nº. 13.303/2016 inaugurates requirements that had hitherto been practiced in the private and overseas markets, such as the constitution of External Audit Committees, directly linked to the Boards of Directors of mixed economy companies and public companies. Adopting the method of the economic analysis of law, this article shows how the phenomenon of corruption can affect the functioning of the Brazilian state-owned enterprises.
Concentração nos mercados de aquisição de gado
Authors: Macedo Conselheiro Alexandre Cordeiro
Published: July 2018

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Os mais relevantes problemas político-eleitorais no Brasil (o sistema proporcional) e a luta contra a corrupção: do “Mensalão” à “Operação Lava Jato”
Authors: Figueiredo Marcelo
Published: July 2018

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PETROGRAPHIC AND GEOCHEMICAL RESEARCH OF THE CARBONATE ROCKS OF THE AREA OF VAFIOCHORI KILKIS
Authors: Ηλιάδου Σ. , Τσιραμπίδης Α. , Κασώλη-Φουρναράκη Α. , Μιχαηλίδης Κ.
Published: July 2018

According to the microscopic examination of thin sections, the examined carbonate rocks are classified in two categories: a. Typical marbles and b. Recrystallised limestones. Category b is distinguished in two sub-categories: Micrites (b1) and sparites (b2). Calcite is the predominant mineral in almost all samples, whereas only in one sample there is a considerable quantity of dolomite. From the unessential minerals quartz, plagioclastes, talc, muscovite and chlorite were identified in traces. It's concluded that nine samples are very pure carbonate rocks and consist of >96% CaC03. The sum of the admixtures, that is all the oxides except for CaO and CO2, ranges from 1,6 to 8,7%, from which the most important is the S1O2 (0,5-6,7%), mainly in the form of quartz and the MgO (0,3-3,6%). The increased participation of Ni2+, Co2+, Rb+ and Zn2 + in relation to the worldwide average, could be attributed to the presence of foreign admixtures which occur in the examined carbonate rocks. The limited participation of Sr2* could be attributed to the absence of feldspars from these carbonate rocks. The mean value of the insoluble residue is 3,1%. The mean value of the included organic matter is 0,3%. Testing the degree of the whiteness it comes out that only one sample is almost absolutely white. Two samples are in the spectrum of the orange color, whereas the hues of six samples are in the spectrum of orange-yellow color. According to the chemical composition of the samples it is concluded that:• The samples from all the formations can be used for aggregates, because with the suitable breaking they can reach the requisite size for every use.• The samples from all the formations can be suitable feedstock for soil conditioners, after suitable grinding, in order to take grain sizes <5 mm, because their content in MgO is < 5%.• The samples from all the formations are considered to be ideal as feedstock in the cement industry, as long as the concentration of fluorine in them is < 0,1%.• The examined formations can be partly used into other industrial sections. However, supplementary specialized tests are needed.
NATURAL RADIOACTIVITY OF GRANITES USED AS BUILDING MATERIALS IN GREECE
Authors: Pavlidou S. , Koroneos A. , Papastefanou C. , Christofides G. , Stoulos S. , Vavelides M.
Published: July 2018

The granites used in Greece as building materials and imported from foreign countries, mainly from Spain and Brazil, are rock types similar with the stony building materials world-wide used. Sixteen kinds of different granites, considered as the most popular, were sampled and their natural radioactivity was measured by gamma spectrometry. The, 226Ra, 232Th and 40K contents of granites were compared to corresponding ones of other building materials as well as other granite types used all over the world. For the reasons of radiological impact from use of granites as building materials, the absorbed dose and the effective dose as well were determined. Although the annual effective dose is higher than the limit of 1 mSv a"1 for some granites examined, they could be used safely as building materials, considering that their contribution in most of the house constructions is very low. An attempt to correlate the relatively high level of natural radioactivity of different kinds of granites with the presence of radioactive minerals and their chemical composition was also made.
PRIMUS BASIN - A MODEL FOR OIL EXPLORATION
Authors: Proedrou P. , Papaconstantinou M. C.
Published: July 2018

An extentional tectonic led to the formation of the basin along marginal listric faults. The fast subsidence created the frame for the accumulation of a thick section of miocene, pliocene and quaternary deposits amounted to 5000 meters and resulted to the good preservation of the organic matter as source for the oil generation. The existence of anticlines and other types of traps around the deepest part of the basin where the oil generation took place is another important factor for discovering hydrocarbons. The growth fault activation led to the formation of roll over anticlines in front of them. Stratigraphie oil bearing traps do also exist. The thick salt layers that were deposited during the upper miocene following the isolation of the basin from the open sea contributed to the reduction conditions in it. Moreover this salt cap rock holds the whole oil migration below it and prescribes the stratigraphie level for the prospects. The short distance between the generation area and the surrounded fault and statigraphic traps accelerated the migration and trapping of the hydrocarbons. The strong relief of the basin due to the fast subsidence led to the extend deposition of turbiditic sediments that form the reservoirs for the majority of the fields.The good knowledge of the geological evolution of the basin and the geochemical processes which take place states the best prepositions for a successful hydrocarbons exploration.
NEW FIND OF ZUNYITE IN ADVANCED ARGILLIC ALTERATION OF RHYOLITES, KOS ISLAND, SOUTH AEGEAN VOLCANIC ARC , GREECE
Authors: Papoulis D. , Tsolis-Katagas P. , Katagas C.
Published: July 2018

Zunyite [Ali3SÌ5C>2o(OH,F)i8CI], an extremely rare mineral, was found as an accessory mineral in highly altered rhyolitic rocks at Kefalos, southwestern Kos, and in a completely kaolinized rhyolitic dyke at Asfendiou, northeastern Kos. It is associated with dickite, kaolinite, quartz and minor pyrophyllite. Kos Island contains both Tertiary and Quaternary volcanic rocks. Zunyite has been identified by XRD and studied by SEM, EDS, Raman spectroscopy and FTIR spectroscopy. The presence of zunyite, in the highly altered samples is significant for the determination of the conditions of the hydrothermal alteration that took place. Zunyite crystals, are up to 90 pm in diameter but usually are less than 10 pm; the crystals are partly covered by kaolinite layers. EDX analyses on the surface of zunyite revealed AI2O3/S1O2 values raging from 2.6 to 2.7. The occurrence of zunyite suggests incorporation of hydrothermal fluids rich in F" and CI", thus indicating contamination by seawater
PETROLOGY - GEOCHEMISTRY AND METALLOGENESIS OF VOLCANIC ROCKS IN THE PETROTA GRABEN/MARONIA, W.THRACE
Authors: Αρίκας Κ. , Βουδούρης Π. , Kloos M. R. , Tesch Ch.
Published: July 2018

The penological, mineralogical and geochemical study of tertiary volcanic rocks from Petrota Graben/Maronia, resulted in the distinction of the following pétrographie groups: a) a high-K calcalkaline group (andesites-dacites), b) a shoshonitic group (shoshonitic andésites, trachytic lavas, c) rhyodacitic ignimbrites and ignimbritic tuffs with high-K calc-alkaline to shoshonitic affinity, and d) rhyolites. The shoshonitic volcanic rocks and the rhyolites are probably originated from the neighbouring Maronia plutonio complex. In addition the calc-alkaline group is related to similar volcanics outcroping in the Mesti-Kassiteres area (the northeastern extension of the Graben). The petrogenesis of the volcanic rocks of the Petrota gragen is attibuted to fractional crystallization and/or magma mixing processes. Epithermal style mineralizations in Mavrokoryfi, Perama Hill and Odontoto are believed to be genetically related to the rhyolitic magmatism in the area.
The Paikon massif revisited, comments on the late Cretaceous - Paleogene geodynamics of the Axios-Vardar zone. How many Jurassic ophiolitic basins? (Hellenides, Macedonia, Greece)
Authors: MERCIER J. L. , VERGELY P.
Published: July 2018

In the Axios-Vardar zone, the Paikon massif has been revisited. To the west, it is composed of a pile-up of SW dipping slices. These have been thrust toward the NNE while the Almopias zone was folding with a SSW vergence. Subsequently thrusting with a SW vergence occurred on the eastern flank of the Paikon massif and in the Almopias zone. These tectonic events took place during the Paleocene - early Eocene and during the upper Eocene - lower Oligocene respectively. During the late Cretaceous, the Almopias zone was a trough whose floor was a late Jurassic ophiolitic sheet. It was located between the Paikon carbonate platform and the Pelagonian platform. This analysis leads to the conclusion that the ophiolites were already located in the Almopias zone before the late Cretaceous and even before the upper Jurassic-lower Cretaceous. It is concluded that during the Jurassic the Almopias zone was an oceanic crust basin, the Paikon zone an island arc and the Peonias zone a back-arc basin. This analysis is a first step which is necessary to precise the geodynamic significance of the Axios- Vardar zone as a whole during the Triassic - Jurassic taking into account the stratigraphie, paleogeographic and structural data and the location in space and time of the magmatic and metamorphic belts
Current overview and treatment of mantle cell lymphoma
Authors: Schieber Michael , Gordon Leo I. , Karmali Reem
Published: July 2018

Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma with historically poor long-term survival compared with other B-cell malignancies. Treatment strategies for this disease are variable and dependent on symptoms and patient fitness. Despite recent advances, MCL remains incurable and patients with high-risk disease have particularly poor outcomes. This review focuses on recent developments that enhance our understanding of the biology of MCL and new treatment approaches that have led to substantial improvements in clinical outcomes. We will outline induction immuno-chemotherapy and maintenance strategies in transplant-eligible patients. In addition, effective strategies for patients unfit for intensive induction will be discussed, with a particular focus on novel molecular therapies with activity in MCL. Lastly, a number of ongoing clinical trials will be presented; the data from these trials are anticipated to redefine standards of care in the near future.
Advances in risk stratification of bladder cancer to guide personalized medicine
Authors: Matulay Justin T. , Kamat Ashish M.
Published: July 2018

Bladder cancer is a heterogeneous disease that poses unique challenges to the treating clinician. It can be limited to a relatively indolent papillary tumor with low potential for progression beyond this stage to muscle-invasive disease prone to distant metastasis. The former is best treated as conservatively as possible, whereas the latter requires aggressive surgical intervention with adjuvant therapies in order to provide the best clinical outcomes. Risk stratification traditionally uses clinicopathologic features of the disease to provide prognostic information that assists in choosing the best therapy for each individual patient. For bladder cancer, this informs decisions regarding the type of intravesical therapy that is most appropriate for non-muscle-invasive disease or whether or not to administer neoadjuvant chemotherapy prior to radical cystectomy. More recently, tumor genetic sequencing data have been married to clinical outcomes data to add further sophistication and personalization. In the next generation of risk classification, we are likely to see the inclusion of molecular subtyping with specific treatment considerations based on a tumor’s mutational profile.
Using zebrafish to study the function of nephronophthisis and related ciliopathy genes
Authors: Molinari Elisa , Ramsbottom Simon A. , Sammut Veronica , Hughes Frances E. P. , Sayer John A.
Published: July 2018

Zebrafish are a valuable vertebrate model in which to study development and characterize genes involved in cystic kidney disease. Zebrafish embryos and larvae are transparent, allowing non-invasive imaging during their rapid development, which takes place over the first 72 hours post fertilisation. Gene-specific knockdown of nephronophthisis-associated genes leads to ciliary phenotypes which can be assessed in various developmental structures. Here we describe in detail the methods used for imaging cilia within Kupffer’s vesicle to assess nephronophthisis and related ciliopathy phenotypes.
Capability Study of Cost Estimating Models for High-Technology Software Projects
Authors: Мясников Максимилиан , Myasnikov Maksimilian
Published: July 2018

According to the analytical companies, software market is the most developing segment of the IT-market. Every year the number of software projects increases, including projects for hi-tech applied areas. In the article the questions of cost estimation of complex software projects are considered. The history of development of scientific cost estimating is considered, the most popular parametrical models are studied: SLIM, COCOMO II, FPA, PRICE-S and SEER-SEM. The author carried out the review of the selected techniques, analyzed their pros and cons and made the comparative analysis by the set criteria. Special attention is paid to the question of applicability of the considered parametrical models for cost estimating of the complex custom software products.
Philosophical and Mystical Traditions of the World
Authors: Жиртуева Наталья , Zhirtueva Natal'ya
Published: July 2018

The monograph studies the mystical phenomenon as the essential core of religion and its universal principle. The comparative analysis of mystical traditions formed on the basis of world and national religions is realized. They have common features as the endeavor to "unite" with the reality of Absolute, which contributes to the transformation of the consciousness and personality of a person through religious psychopractices.
The monograph is interdisciplinary. The parallels between the scientific and philosophical and mystical pictures of the world are realized, the psychological and social vectors of mysticism are explored.
Poland, Lithuania, Latvia, Estonia: socio-economic and political development
Authors: Клемешев Андрей , Klemeshev Andrey , Федоров Геннадий , Fedorov Gennady , Межевич Николай , Mezhevich Nikolay , Тарасов Илья , Tarasov Il'ya , Зверев Юрий , Zverev Yuriy , Гуменюк Иван , Gumenyuk Ivan , Кузнецова Татьяна , Kuznecova Tat'yana , Мегем Максим , Megem Maksim , Винокуров Владимир , Vinokurov Vladimir , Ворожеина Яна , Vorozheina Yana , Уразбаев Евгений , Urazbaev Evgeniy
Published: July 2018

The monograph is devoted to topical problems of socio-economic, demographic and political development of Poland and the Baltic countries (Lithuania, Latvia and Estonia). The main features and tendencies of development of military-political situation in the Baltic region are considered. It is intended for specialists engaged in studying the economic, political and geopolitical aspects of the development of the Baltic region, teachers and university students.
O DIREITO SOCIAL À MORADIA COMO LIMITE À INCIDÊNCIA DO ITCD SOBRE IMÓVEIS DE FAMÍLIAS CARENTES
Authors: Oliveira Fernanda Loures de , Carmona Paulo Afonso Cavichioli
Published: July 2018

Os direitos sociais foram capitulados como direitos fundamentais pela Constituição. Nesse sentido, torna-se importante delimitar certo conteúdo de eficácia jurídica aos seus preceitos. Especificamente quanto ao direito social à moradia, embora seja bastante controvertido seu conteúdo eficacial mínimo sob a ótica prestacional, não se apresentam as mesmas dificuldades quando o assunto é seu viés negativo, incluindo sua atuação como limite à tributação. Por isso, a partir do método da revisão bibliográfica, e mediante a identificação e análise das legislações tributárias dos Estados e do Distrito Federal, pretende-se traçar a delimitação da eficácia jurídica do direito social à moradia, ao menos sob sua ótica negativa, no que concerne à incidência do imposto de transmissão causa mortis sobre imóveis de famílias carentes. Destacando-se as previsões locais mais condizentes com esse direito social, pretende-se dar a temática uma análise mais global, pautada no potencial do direito social à moradia como efetivo limite à tributação, mesmo para os casos em que não haja previsão legal específica. Nesse contexto, entende-se que o imposto sobre a transmissão causa mortis não deve incidir quando tendente à supressão do único imóvel pertencente à família carente, que atenda, em tese, os pressupostos para sua inclusão em política pública habitacional.
Criptomoedas. Impactos na economia global. Perspectivas
Authors: Sichel Ricardo Luiz , Calixto Sidney Rodrigues
Published: July 2018

O tema abordado está direcionado à análise do fenômeno social mundial das criptomoedas e sua influência na economia e no direito, especialmente com relação à inovação e análise econômica do direito, no período de 2009 a 2017. O objetivo deste artigo visa demonstrar a importância de se compreender esse fenômeno tecnológico que está rompendo paradigmas econômicos e sociais, maravilhando o mundo com suas possibilidades e alarmando com seus efeitos econômicos.
O DIREITO À CIDADE NO CONTEXTO DAS SMARTS CITIES: O USO DAS TIC’S NA PROMOÇÃO DO PLANEJAMENTO URBANO INCLUSIVO NO BRASIL
Authors: Araújo Douglas Da Silva , Guimarães Patrícia Borba Vilar
Published: July 2018

O presente estudo pretende investigar como o planejamento urbano numa abordagem bottom-up está sendo implantado no Brasil, na construção de cidades inteligentes e democráticas. Diante da estimativa que mais de 90% da população brasileira viverá em cidades no ano de 2030, surge a necessidade de pensar métodos e táticas estratégias e inovadoras para o planeamento urbano. As tendências ao uso das TICs (tecnologias de informação e comunicação) exercem papel significativo no século XXI, tanto na prestação de serviços públicos, quanto na gestão das cidades com vistas à participação ativa dos cidadãos. A exemplo de outras cidades, como Nanterre na França, que desenvolveram aplicativos e plataformas digitais como instrumentos de gestão urbana, visando proporcionar um engajamento cívico mais efetivo, é preciso analisar quais práticas com a mesma finalidade têm sido desenvolvidas no Brasil. Sob o prisma metodológico, serão empreendidos estudos de casos relativos às experiências adotadas por municípios brasileiros. As conclusões obtidas demonstraram que as TICs são ferramentas responsáveis por instrumentalizar a participação social no âmbito do planejamento urbano (inclusivo) das smart cities.
A descriptive study of trends in the pictures drawn by primary school learners in South Africa
Authors: Brits Hanneke
Published: July 2018

Background:

Illness, lack of vocabulary and unwillingness to discuss emotional distress may contribute to poor communication with children. Drawings may play a crucial role in enhancing communication with this patient group.

Aim:

This study aimed to describe the pictures drawn by primary school learners in the children's palliative care programme in Bloemfontein, South Africa, and to evaluate whether drawings can be used to assess emotional wellbeing.

Methods:

Drawings were assessed according to standardised human figure drawing guidelines and emotional indicator (EI) scales. Pictures were discussed with the child and compared with the clinical presence of depression or emotional discomfort.

Results:

A total of 29 pictures drawn by 20 children were assessed. Of the 20 participants, 18 were boys, with a mean age of 10.2 years, and 12 children were assessed as having clinical depression.

Conclusions:

The presence of two or more EIs, small pictures or pictures in dark colours may indicate clinical depression. Health professionals are advised not to try to interpret the picture, but to use the picture to enhance communication. Let the child explain the picture, rather than relying only on the assessment tool.
Evaluation of a pilot service to help young people with life-limiting conditions transition from children's palliative care services
Authors: Hutcheson Sinead , Maguire Hilary , White Clare
Published: July 2018

Background:

When young people with life-limiting diagnoses become too old for children's hospice services, they often experience challenges transitioning into adult services. A two-year pilot project was developed to try to aid transitioning, which involved a day service with occasional overnight trips.

Aim:

To evaluate the pilot project.

Method:

Three focus groups made up of key stakeholders (young people, their parents and staff) were set up and analysed using an adopted thematic analysis framework.

Results:

The participants consisted of three young people, seven parents and six staff members. Participants described the transition period as a difficult time for both young people and their families, with a perceived lack of adult services available. All groups agreed that the pilot had a positive impact on young people and their families and all were keen for the project to continue.

Conclusion:

This pilot models a service that could be adopted by other organisations in order to aid the transition between child and adult hospice services, with further potential for application in mental health and special needs services.
Los jóvenes y la historia: Los jóvenes y la Historia en el Mercosur. Temporalidades y enseñanza de la Historia
Authors: Mainardes Waiga Juliano
Published: July 2018

ResumenEste trabajo presenta una investigación cuantitativa sobre las concepciones del tiempo más aceptadas entre los jóvenes estudiantes. Los datos analizados proceden del cuestionario realizado a alumnos argentinos del proyecto «Jóvenes y la Historia en el Mercosur». Problematizaremos en la reflexión la relación entre referentes teóricos, concepciones de tiempo y Enseñanza de la Historia. Nuestro objetivo es mejorar la comprensión de la relación difícil entre las concepciones de tiempo y enseñanza de la historia. Además de la búsqueda de soluciones inmediatas el texto propone diversas causas, porque creemos que el problema planteado refleja tanto las debilidades de la enseñanza de la historia como las deficiencias estructurales de la educación escolar.
Assessing Ten Years of Inter- and Transdisciplinary Research, Education, and Outreach: The Competence Center Environment and Sustainability (CCES) of the ETH Domain
Authors: Kassab Omar , Schwarzenbach René P. , Gotsch Nikolaus
Published: July 2018

While there is a growing consensus about the role of academia in tackling the grand challenges of sustainability, the current incentive and reward system does not yet provide the right environment. Inter- and transdisciplinary research centers can bring about the needed cultural change.Research
centers have emerged as organizational structures to meet the manifold expectations raised towards sustainability science, a field characterized by high levels of inter- and transdisciplinarity. In this article, we assess the impact of the Competence Center Environment and Sustainability (CCES)
of the ETH Domain. Encompassing more than 800 participants from six research institutions in Switzerland, the research center has been in operation for ten years (2006 to 2016). Focusing on its three areas of activity ‐ research, education, and outreach ‐ we analyze which decisions
have influenced the development and legacy of CCES. We formulate five recommendations, which could prove useful for the future design and evaluation of comparable enterprises. Finally, we conclude that the academic incentive and reward system has to open up for inter- and transdisciplinarity.
Research centers like CCES can facilitate this cultural change by providing the necessary academic environment and forming a new generation of researchers in key fields.
Über Wissensintegration im humanökologischen Kontext: Bericht von der Jahrestagung 2018 der Deutschen Gesellschaft für Humanökologie
Authors: Tretter Felix , Simon Karl-Heinz
Published: July 2018

Wie (Noch)Nichtwissen kommunizieren und verantworten? Wie Metawissen etablieren, um Wissensbestände zu reflektieren? Diese und andere Aspekte der Wissensintegration diskutierte die Deutsche Gesellschaft für Humanökologie. Deutlich wurde: Bei der Lösung von Nachhaltigkeitsproblemen
gilt es, sowohl zwischen Wissenstypen zu unterscheiden als auch deren Zusammenwirken zu berücksichtigen.
Blockchain Potential in Tilapia Supply Chain in Ghana
Authors: Rejeb Abderahman
Published: July 2018

In a country like Ghana where Tilapia is the most preferred and cheapest source of animal protein, closer attention must be paid to the supply chain of such a product. This paper examines the major issues and problems in Tilapia supply chain and logistics in Ghana, and it suggests the intervention of the new and disruptive technology of blockchain.  Blockchain technology can have the potential to revolutionize the supply chain of Tilapia in Ghana and bring many advantages to the flow of Tilapia from farmers till the end consumers. Besides, it highlights the role of blockchain in ensuring food safety and in rebuilding a trustful network of Tilapia distribution between producers and customers. A model of Tilapia supply chain based on blockchain technology will be exhibited and explained to provide relative solutions to supply chain management processes of Tilapia.
Root Resorption in Relation to Orthodontic Tooth Movement
Authors: Ramanathan Chaitra , Hofman Zdeněk
Published: July 2018

Root resorption is an undesirable sequela of orthodontic tooth movement. The odontoclasts are responsible for root resorption and the process of hyalinization is known to preceed the orthodontic root resorption. It is found that there are several predisposing factors, therefore an evaluation of these factors should be done by careful examination of personal medical history, severity of malocclusion and dental treatment (if any due to previous history of trauma), anterior crossbite etc. The evaluation becomes an essential factor as it helps the orthodontists in detecting the occurance and severity of the root resorption and thereby plan out the treatment more effectively. Orthodontic tooth movements especially intrusion and other movements like tipping, torque are all known to influence the root resorption, therefore the detection using radiographs and repair of root resorption is of utmost significance as root resorption is a more serious problem from a medicolegal stand point of view. However some studies have shown that the repair process is known to occur after the cessation of orthodontic treatment by the deposition of cementum of cellular type. In the light of orthodontist’s liability of what is basically an unpredictable phenomenon, it is necessary that the speciality define this uncertainity and protect its members against unnecessary and unjustified litigation.
Inhibition studies on α-amylase using isothermal titration calorimetry
Authors: Gyémánt Gyöngyi , Lehoczki Gábor , Szabó Kármen , Kandra Lili
Published: July 2018

The control of postprandial blood glucose level via the inhibition of α‐amylase is a relevant strategy for the treatment of type 2 diabetes. Several antidiabetic plants are known but there is no information about their α-amylase inhibitory activity. This in vitro study tries to reveal the answer. Hot water extracts of 58 medicinal plants and spices were examined. Activity measurements of human salivary α-amylase (HSαA) on 0.14 m/v % starch substrate was carried out by isothermal titration calorimetry in the presence or absence of plant extracts. Water soluble antioxidant capacity of each extract was measured with photo-chemiluminescence method. Results have confirmed the inhibitory activity of several plant extracts against HsαA. The green tea, cinnamon and allspice, furthermore leaves of blackberry, raspberry and strawberry deserve particular mention (IC50≤ 1.2 mg/mL). A few extracts had significant water-soluble antioxidant capacity compared to ascorbic acid and a weak correlation was recognised between the obtained IC50and antioxidant capacity values. Inhibition of amylases located in digestive system can be reached via daily intake of most active extracts. These plants could be inserted effectively into a diabetic diet as food supplements.
Bioactive glass combined with zein as composite material for the application in bone tissue engineering
Authors: Hum Jasmin , Naseri Shiva , Boccaccini Aldo R.
Published: July 2018

The present study has focused on the development of new composite scaffolds based on the combination of zein with bioactive glass for the application in bone tissue engineering. Porous polymeric matrices were produced by the salt leaching technique. By incorporating 45S5 bioactive glass particles the lack of bioactivity can be remedied. However, the addition of bioactive glass is influencing the plasticization behavior of the zein matrix during the salt leaching which negatively affects the compression strength as well as the degradation behavior. This paper describes the process during leaching and explains the different behavior of zein with and without the presence of bioactive glass