bluuebunny/crossref_metadata_2025 huggingface dataset:
Anti-proliferative and apoptotic effect of tetrahydrobenzo[h]quinoline on MCF-7 human breast cancer cell
Authors: Ghaffari Maryam , Shanehbandi Dariush , Sarhadi Solmaz , Hanifeh Ahagh Mina , Maleki Moghaddam Mahsa , Dehghan Gholamreza , Ghodsi Razieh , Ezzati Nazhad Dolatabadi Jafar
Published: September 2021

Background: Quinoline and its derivatives display various biological activities based on versatility in designing a new drug class for medicinal applications. Hence, synthesizing innovative and varied derivatives of quinoline has gained considerable attention among chemists and biologists. This study evaluated the anti-proliferative and apoptotic effect of tetrahydrobenzo[h]quinoline on Michigan Cancer Foundation-7 (MCF-7) human breast cancer cells. Methods: The anti-proliferative effect of tetrahydrobenzo[h]quinoline was studied via MTT [3 0-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide] assays. A quantitative and qualitative study of apoptosis was carried out via flow cytometry and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL). Quantitative real-time PCR (qPCR) and immunoblotting analysis were employed to identify the expression level of genes and proteins involved in the apoptosis signaling pathway. Results: The synthesized compound reduced 50% of cell growth at concentrations of 10 and 7.5 µM during 24 and 48h, respectively, and induced apoptosis up to 30% in MCF-7 cancer cells. Regarding the gene expression level, Bcl-2 displayed considerable alleviation, whereas Bax expression increased significantly. Despite the remarkable increase in caspase 9 expression, there was no noticeable difference in the caspase 8 expression in treated cells compared to the control group. Western blotting data showed that the protein expression level of Bcl-2, pro-caspase 8, and 9 reduced. The protein content of Bax, cleaved-caspase 8, and 9 increased significantly, of which the protein level of cleaved-caspase 9 exhibited a tremendous rise in the treated group. Conclusion: The newly synthesized tetrahydrobenzo[h]quinoline can be a promising organic compound for cancer treatment if its anti-cancer effect investigates by other types of breast cancer cells. In vivo studies should be used to investigate the anti-cancer efficiency of this compound.
The clinical characteristics and treatment approaches of COVID-19: a concise review
Authors: Eslamkhah Sajjad , Alizadeh Nazila , Hajiasgharzadeh Khalil , Eslamkhah Masoud , Mokhtarzadeh Ahad , Baradaran Behzad
Published: September 2021

A series of cases of pneumonia occurred in China in late 2019. For this type of coronavirus, the WHO formally identified the condition as a coronavirus disease 2019 (COVID-19). They announced that this disease is the recent main concern of health problems in the world. Transfer of this novel coronavirus (nCoV) from human to human exists predominantly among family members, who have close contact with each other. This review article is provided based on the recent findings of COVID-19, which were retrieved by searching PubMed, Google Scholar, Scopus, and Web of Science until December 2020. Here, we highlighted the coronaviruses types, COVID-19 symptoms, epidemiology of the disease, transmission ways, and nCoV related pneumonia pathogenesis and continue with characteristic features and treatment methods. While no approved treatments are available for this type of infection therapy but several drugs may have potential benefits. It seems that identifying the detailed characteristics of the novel coronavirus disease offers the foundation for further research into the production of effective anti-COVID-19 drugs and vaccines.
Resveratrol prevents lipopolysaccharide-induced cognitive impairment in rats through regulation of hippocampal GluA1-containing AMPA receptors
Authors: Hassanzadeh-Taheri Mohammadmehdi , Hayati Somayeh , Mohammadifard Mahtab , Hosseini Mehran
Published: September 2021

Background: Evidence suggests that dysregulation in AMPA-type glutamate receptors (AMPA-Rs) has been associated with the pathogenesis of Alzheimer's disease (AD), especially during its early phase. Hence, the present study was performed to elucidate the impact of resveratrol (RV) on hippocampal expression of AMPA-Rs in a rat model of AD. Methods: A rat model of cognitive deficits was developed by a stereotactic intracerebroventricular infusion of lipopolysaccharide (LPS) in male Wistar rats (n=24). The LPS+RV30 group (n=12) received intraperitoneal injections of RV (30 mg/kg) at 30 min, 12 h, and 24 h before LPS injection. Meanwhile, the model (LPS) and sham (SO) groups only were treated with the vehicle solution (normal saline containing 1% ethanol). One day after the LPS infusion, the mRNA expressions of AMPA-Rs subunits (Gria1-4) were evaluated by RT–PCR. In addition, hippocampal levels of lipid peroxidation, superoxide dismutase, and nitric oxide were assessed. Seven days after the LPS challenge, the remaining animals (n=6 each group) were subjected to the Y-maze task, and the expression and localization of GluA1-containing AMPA-Rs in their hippocampi were investigated immunohistochemically. Results: Pretreatment with RV prevented LPS-induced cognitive dysfunction in rats and enhanced their working memory performance. Moreover, RV could moderately prevent oxidant-antioxidant imbalance in rats' hippocampi. RT-PCR results revealed that the hippocampal mRNA expression of the Gria1 was significantly reduced, while the expressions of Gria2 and Gria3 were increased in LPS-challenged rats. RV significantly modulated the alteration in the Gria1 mRNA expression; however, it could not influence the Gria2 and Gria3 mRNA expressions. The immunohistochemical assessment showed a significantly reduced immunoreactivity for GluA1-containing AMPA-Rs in all hippocampal subfields of the LPS group, and RV could effectively ameliorate the alteration. Conclusion: This study is the first to report that RV could modulate GluA1-containing AMPA-Rs dysregulation in a rat AD model.
Academic burnout among undergraduate nursing students: Predicting the role of sleep quality and healthy lifestyle
Authors: Naderi Habibolah , Dehghan Hamidreza , Dehrouyeh Shahrbanoo , Tajik Elaheh
Published: September 2021

Background: Academic burnout is a serious threat that can affect any student’s academic life, especially nursing students. Sleep quality and a healthy lifestyle are variables are related to academic burnout. This study aimed to predict undergraduate nursing students’ academic burnout based on sleep quality and lifestyle. Methods: The study was descriptive and correlational in design. The statistical population included all undergraduate nursing students of the Razi School of Nursing and Midwifery at the Kerman University of Medical Sciences (Kerman, Iran; 2016-2017 academic year). Of 270 students,143 students were selected using a random cluster sampling method. The Academic Burnout Questionnaire, the Pittsburgh Sleep Quality Index (PSQI), and the LifeStyle Inventory were used to collect data. A linear regression analysis using the enter method was employed for data analysis. Results: There was a significantly positive correlation between students’ academic burnout and total PSQI score (P=0.000, r=0.547) and some of its sub-scales, including subjective sleep quality (P=0.000, r=0.607), sleep latency (P=0.019, r=0.196), sleep duration (P=0.014, r=0.206), sleep disturbance (P=0.000, r=0.346), and daytime dysfunction due to sleepiness (P=0.000, r=0.654). Conversely, the relationship between students’ academic burnout and healthy lifestyle was negatively significant (P=0.000, r=-0.507). Thus, the potential for undergraduate nursing students’ academic burnout can be predicted by sleep quality and lifestyle (P=0.000, F=23.480). Conclusions: By improving sleep quality and living a healthier lifestyle, students may be less likely to experience academic burnout.
Adapting to a new world through virtual medical education
Authors: Zaidi Shabih , Abbas Shifa
Published: September 2021

non
Parents Shape their Children’s Physical Activity During Unstructured Recess Through Intrinsic Value the Children Possess
Authors: Deng Yangyang , Hwang Yongju , Layne Todd , Yli-Piipari Sami
Published: September 2021

Parents beliefs processes has shown to relate to their children’s decisions making. Thus, grounded in the expectancy-value theory, the aim of this study was to examine parents’ role in shaping elementary school students’ beliefs and task values toward students’ school-time physical activity (PA) and their moderate-to-vigorous (MVPA) behavior during unstructured recess. A convenience sample of 115 (Mage = 10.12±1.81) children and their parents/guardians were recruited, and their expectancy-beliefs and attainment, utility, and interest values toward school-time PA were assessed. In addition, children’s MVPA during recess was measured using waist-attached accelerometers. Results showed that parents impacted children’s recess PA in different ways depending on children’s gender. In girls, parents’ beliefs and values transferred directly to the subsequent values of their children, whereas parents’ beliefs were the central predictors of boys’ beliefs and values. Parents’ intrinsic value moderated girls’ MVPA via the intrinsic value of the participants possessed (Z = 1.73, p = .010, 90% CI [.36, 2.93]), whereas parents’ beliefs moderated boys’ intrinsic value – MVPA relationship (Z = .78, p < .001, 90% CI [.39, 1.10]). This study suggests applying gender-specific strategies when trying to understand how beliefs and task values impact PA-related behaviors.
THE USE OF LEXICAL COLLOCATIONS IN SOME ARTICLES OF SEVENTEEN.COM WEBSITE
Authors: Tayibnapis Marsya Aprila , Meilinda Lina , Purnamasari Yessy
Published: September 2021

Collocations are one of the problems faced by EFL (English as a Foreign Language) learners when learning English language. This study is intended to help the EFL Learners and non-native English speakers to add knowledge about collocations. Therefore, this study is aimed to find the use of lexical collocations and their meaning. This study used a descriptive qualitative research technique. The source of the data is eleven articles from eight sections in seventeen.com. om the research, there were 79 lexical collocations and they were classified as six out of seven types that Benson et al. (2010) proposed. The data showed that the most used type is L3 (adjective + noun) and the least used is L4 (noun + verb). The meaning of the lexical collocations was defined from the contexts.
Apricot (Prunus armeniaca L.) promise cultivars frost resistance and winter-hardiness under the conditions of the Right-Bank subzone of the Ukraine’s Western Lisosteppe
Authors:   Institute of Horticulture of the National Academy of Agrarian Sciences of Ukraine, Ignatenko O.O. , Moiseichenko N.V. ,   Institute of Horticulture of the National Academy of Agrarian Sciences of Ukraine, Vasylenko V.I. ,   Institute of Horticulture of the National Academy of Agrarian Sciences of Ukraine
Published: September 2021

In the winter-spring period of 2019-2020 the researches were carried out on the territory of the Institute of Horticulture of the National Academy of Agrarian Sciences (IH NAAS) of Ukraine (the Kyiv region) under the field and modeled conditions in order to determine the influence of variable temperatures on the frost resistance and winter-hardiness of five apricot cultivars bred in Crimea (Nikitsky Botanical Garden). Cv Siaivo of IH NAAS was used as the control. The varieties estimation in the natural conditions showed that they were characterized with high winter-hardiness and frost resistance in all the variants of the experiment in the orchards. During the relatively cool winter of 2018/2019 with the minimum temperature -14,2°C the damage of the shoots tissues and buds were by almost two times more severe (all the strains) than in the nearly frostless winter of 2019/2020. When testing in the laboratory under t -25 °C the difference in the cultivars damage by years was not considerable, its general level being higher than in the winter period of 2018/2019 (in the control freezing was not utilized). At the same time under a temperature of -30 °C percent of the damage of most of cvs (5 out of 6) was higher in the winter of 2019/2020. That showed the importance of the cold influence on the plants preparation to the effect of low temperatures. The usage of such temperatures as -30 °C established the critical level of their influence on the varieties, especially on such tissues as the top and generative buds of the one-year increment. In the field conditions under the effect of the critical temperatures, namely: after the long thaw the plants could lose crop at all as their generative buds did not endured significant air temperature fluctuations which took place in the winter period of 2019/2020. However, with the proper management the trees could be restored after the stress influence, the crop losses being rather substantial though. It was the strain Vynoslivyi that appeared the most frost resistant and can be applied in breeding as one of the parental forms and grown in sufficiently great industrial volumes.
Economic and biological assessment of the apple (Malus domestica Borkh.) hybrid offsprings in the conditions of the Right-Bank Lisosteppe of Ukraine
Authors:   L.P. Symyrenko Research Station of Pomology of the Institute of Horticulture, NAAS of Ukraine, Voloshyna V.V. , Gomeniuk V.I. ,   L.P. Symyrenko Research Station of Pomology of the Institute of Horticulture, NAAS of Ukraine
Published: September 2021

The authors present the results of the assessment valuable economic and biological traits of the apple hybrid offspring in the right-bank part of the Western Lisosteppe of Ukraine. As a result of the multi-years breeding work conducted at the L.P. Symyrenko Institute of Pomology of NAAS (now the L.P. Symyrenko Research Station of Pomology IH NAAS of Ukraine) a number of cultivars and elite hybrid forms were selected according to the valuable economic and biological traits (yield, disease resistance, drought-resistance and winter hardiness), namely: of the autumn maturity – 9/80, 9/93, 11/1, 11557, 11/5-54, 9-8-7, 10947; winter – Myr, Debiut (11/42), 11/40, 11/47, 11/50, 12/130, 2-153-6, 10868, 11495, 11009. During 2011-2020 two new apple cvs were created – Myr and Debiut. In 2019 the Ukrainian Institute for the Plant Variety Examination submitted documents for obtaining a patent and entry into the State Register … for the column strain Debiut. This is a cultivar of the early winter maturity, on the rootstock 54-118 begins fruit-bearing on the second year. The fruits are of the medium size, round-conical, slightly ribbed. The main coloration is yellow, integumentary – a faint pink-red blush on the sunny side with a great number of large white lentils. In the ordinary storage the apple are stored for up to 4-5 months. In 2020 this cultivar was entered into the specified register. In the same year the certificate was obtained for the cv Myr – of the winter maturity, on the rootstock M.9 begins fruitbearing in the second year. The fruits are of the medium or of the larger than average size, flattened-spherical, greenish-yellow, when ripe-yellow, with a slight light pink-red faintly blurred blush with well-defined stripes. In the ordinary storage the apples are stored until April, in the refrigerator until May-June.
História Política de Sobral: No tempo de Prado e Barreto (1963-96)
Authors: Silveira Edvanir Maia da
Published: September 2021

Até o momento do advento do Regime Militar, sentia-se que a atualização institucional e política da Princesa do Norte tinha sido escassa, exceto pela incorporação de uma ou outra inovação introduzida pela caminhada civilizatória geral do país, em consonância com a do mundo. Mas, passados os primeiros anos do governo militar, estabeleceu-se um quadro de desenvolvimento intenso no Brasil, que se convencionou chamar de “milagre brasileiro”. Por algum tempo houve recursos de sobra, que partiam do governo federal em direção aos estados e municípios, disponibilizados em grande medida pelo sistema financeiro internacional, que era o sustento principal das altas taxas de crescimento econômico. Tudo isso acontecia em meio ao poder discricionário constituído em Brasília, que contaminava tudo e todos. Mas os recursos federais não chegavam aos estados e municípios senão por meio de uma ordem política muito bem azeitada, estruturada em torno do partido oficial da ditadura, a ARENA. Nesses anos, a liderança política em Sobral coube a duas famílias eminentes, os Prado e os Barreto, que se adaptaram bem à realidade política nacional, e souberam explorar bem os canais por onde fluíam os recursos. Mais adiante, um terceiro clã, os Ferreira Gomes, passou a disputar o poder municipal, trazendo mais intensidade às disputas políticas. Tal adaptação à realidade política foi de tal monta que, mesmo concorrentes nos pleitos municipais, o mesmo suporte partidário foi utilizado por um e outro, sob a denominação das sublegendas ARENA 1 e ARENA 2, estranha solução política que não foi singular em Sobral, mas Brasil afora.
Conceptualising strategic litigation
Authors: Van der Pas Kris
Published: September 2021

This article conceptualises the term “strategic litigation” in order to provide for a definition of it. Strategic litigation is a tool increasingly used in Europe by individuals and organisations to attain different objectives. Next to that, there is increasing academic attention for the topic. Nevertheless, the exact definition of “strategic litigation” remains unclear. Therefore, this article uses the research method of conceptualisation as well as a database research and additional literature to provide for a definition. It looks firstly at the background concept, involving the range of meanings associated with the term “strategic litigation”, after which a systematised concept is formed. Thereby, use is made of the “necessary and sufficient conditions” (NSC) approach, to develop the conditions necessary and/or sufficient for a case to fit within the category of strategic litigation. Moreover, the external conceptual relations of the term are explored.
El derecho a la verdad en la jurisprudencia de la Corte Interamericana de Derechos Humanos a la luz de las teorías de la justicia
Authors: Druliolle Vincent
Published: September 2021

El artículo analiza el derecho a la verdad en la jurisprudencia de la CIDH a la luz de las teorías de la justicia. En la primera parte se argumenta que, aunque el concepto de justicia transicional no puede asimilarse a ninguna de las teorías de la justicia existentes, se puede definir como un concepto multidimensional que combina varios elementos de dichas teorías. Tras explicar la medida en qué varias dimensiones de las teorías de la justicia se ven reflejadas en el derecho a la verdad tal y como lo define la CIDH, se subrayan algunos límites de la conceptualización de la Corte, en particular el hecho de que ignora la dimensión procedimental de la justicia. Así pues, la conclusión presenta un argumento a favor de la deliberación democrática, lo cual nos obliga a repensar el papel de los tribunales en la construcción de un relato sobre el pasado.
Miniaturisasi antena mikrostrip array 4×1 elemen menggunakan teknik peripheral slits
Authors: Kartika Putri Tiara , Alam Syah , Surjati Indra
Published: September 2021

Sistem komunikasi WiFi telah banyak digunakan dalam kebutuhan sehari-hari antara lain untuk keperluan koneksi dan jaringan internet. Dalam penelitian ini, dilakukan miniaturisasi dari antena mikrostrip array linier 4×1 elemen yang bekerja pada frekuensi 2,4 GHz. Pereduksian antena dilakukan dengan metode simulasi dengan penambahan peripheral slits. Efek dari penambahan slit pada patch antena dapat menggeser frekuensi kerja antena menjadi lebih besar sehingga untuk mengembalikan antena pada frekuensi kerjanya dilakukan miniaturisasi dimensi patch antena. Dari hasil simulasi dan optimasi, didapatkan hasil desain yang paling optimal adalah antena mikrostrip patch array 4×1 dengan 16 slit. Penambahan jumlah slit menunjukan dimensi antena berhasil direduksi sebesar 20,45% dengan ukuran patch 28 mm x 20 mm. Nilai koefisien refleksi yang didapatkan sebesar -16,31 dB, gain  sebesar 6,43 dB, dan VSWR 1,36 pada frekuensi kerja 2,4 GHz. Penelitian ini bermanfaat sebagai usulan disain antena penerima untuk sistem komunikasi WiFi.
Perancangan dan realisasi aplikasi manajemen kegiatan asrama berbasis Android dan RFID
Authors: Maulana Asep , Hasanah Rahmawati , Haidar Andry
Published: September 2021

Manajemen kegiatan asrama diperlukan sebagai media informasi bagi anggota asrama dalam mengetahui informasi dan kegiatan selama berada di asrama. Saat ini, di asrama kampus Polban, penyampaian informasi seputar asrama seperti kegiatan, pendataan paket, pencatatan presensi, dan pelaporan fasilitas yang bermasalah masih menggunakan media konvensional seperti menghubungi pengurus secara langsung maupun papan informasi. Selain itu data-data asrama juga masih berdasarkan paper based sehingga rentan terhadap keamanan data. Pada penelitian ini, dibuat perancangan dan realisasi aplikasi manajemen kegiatan asrama berbasis Android dan Radio Frequency Identification (RFID). Sistem ini diperuntukkan bagi penghuni asrama agar lebih mudah dalam mengakses pengingat kegiatan, informasi presensi, informasi kiriman paket, pelaporan fasilitas yang rusak, dan monitoring jumlah mahasiswa. Hasilnya, pada hardware sistem presensi, perangkat dapat melakukan presensi dengan waktu tidak lebih dari 3 detik pada setiap ID kartu dengan jarak pembacaan maksimal 3 cm dari permukaan perangkat. Integrasi antara perangkat presensi dengan aplikasi Android tidak lebih dari 3 detik pada waktu sebelum presensi dan tidak lebih dari 6 detik pada waktu presensi. Aplikasi Android telah diuji dari total 24 poin tanggapan yang diberikan kepada responden, 8,33% menyatakan cukup, 83,33% menyatakan baik, dan 8,33% menyatakan sangat baik.
Studi perbandingan hasil pengukuran resistansi pembumian menggunakan tiga metode pengukuran yang berbeda
Authors: Sunarto Sunarto , Trisnawiyana Trisnawiyana
Published: September 2021

Sistem pembumian merupakan proteksi untuk keselamatan dengan menyalurkan arus gangguan ke bumi dan nilai resistansi pembumian harus sekecil mungkin. Oleh karena itu, untuk mengetahui besarnya nilai resistansi pembumian perlu dilakukan pengukuran resistansi elektrode pembumian. Untuk mengukur resistansi elektrode pembumian diperlukan alat ukur earth tester. Pengukuran menggunakan earth tester terdapat dua metode yaitu metode tiga titik dan metode dua titik. Metode tiga titik menggunakan tiga konektor pada earth tester yaitu konektor C, P, dan E, sedangkan metode dua titik hanya dua konektor yang digunakan yaitu konektor C dan E, sumber dari luar diinjeksikan ke konektor C. Selain kedua metode tersebut bisa menggunakan metode Volt-Ampere untuk mengukur resistansi pembumian. Metode ini menggunakan dua alat ukur yaitu Voltmeter dan Ampere meter. Tujuan penelitian ini adalah untuk membandingkan hasil pengukuran resistansi pembumian menggunakan tiga metode tersebut. Hasil penelitian menunjukkan bahwa pengukuran resistansi pembumian yang paling baik adalah metode tiga titik menggunakan alat ukur earth tester. Hal ini karena tidak pada metode ini tidak diperlukan sumber dari luar dan paling banyak mengahsilkan hasil pengukuran yang nilainya homogen.
Prediksi usia pakai baterai pada sistem pencadangan unit 3 PLTU Suralaya
Authors: Fauziah Dini , Laksono Riyan Indra
Published: September 2021

Sistem cadangan sangat penting dan wajib dimiliki dalam sebuah sistem produksi. Sistem ini berfungsi untuk menjaga keandalan dari sistem tersebut. Pembangkit Listrik Tenaga Uap (PLTU) PT. Indonesia Power Suralaya merupakan salah satu perusahaan penghasil listrik yang menggunakan baterai sebagai sistem cadangan, terutama pada peralatan listrik yaitu menggunakan sistem baterai 220 VDC. Pada sistem pencadangan ini terdiri dari 104 sel baterai dan masing-masing sel baterai bernilai 2 VDC berjenis asam timbal. Masalah yang sering terjadi pada sistem baterai tersebut yaitu suhu kerja yang melebihi suhu yang ditentukan oleh spesifikasi baterai untuk bekerja maksimum dikarenakan faktor cuaca lingkungan. Permasalahan ini berdampak terhadap usia pakai baterai menjadi lebih pendek. Oleh karena itu, penelitian ini bertujuan untuk mengetahui pengaruh suhu lebih terhadap usia pakai baterai asam timbal. Data pada penelitian ini diperoleh berdasarkan pengukuran rutin bulanan yang diukur langsung menggunakan thermogun dengan analisis data menggunakan metode regresi linier. Berdasarkan hasil analisis didapat bahwa usia pakai baterai pada saat kondisi ini akan bertahan selama 13 tahun 2 bulan sejak awal dipasang yaitu sejak bulan Februari tahun 2017, dengan usia pakai seharusnya yaitu 20 tahun atau berkurang sekitar 7 tahun (± 35%) dibandingkan spesifikasinya. Dengan demikian, pada bulan Agustus tahun 2029 baterai direkomendasikan untuk diganti.
Animaciones musicales: danza del hada de azúcar de la Suite "El cascanueces", de Chaikovski
Authors: de Frutos Domínguez Rocío , Galera Núñez María del Mar
Published: September 2021

Se trata de una animación realizada sobre un fragmento de la la Danza del hada de azúcar de la Suite “El cascanueces” de Chaikovski. Se ha optado por una estética visual con elementos figurativos de la naturaleza que se emplean para resaltar la forma musical y otros parámetros sonoros y psicológicos de la obra.

En el proyecto Animaciones Musicales, a las alumnas y alumnos del grado de Educación Infantil dentro de la asignatura de Didáctica de la Música se pedía elegir libremente una pieza musical instrumental de entre 1 y 4 minutos de duración y, tras su análisis (forma, carácter, parámetros sonoros y elementos más relevantes...), realizar sobre esa base musical una creación visual de animación (empleando el programa PowToon o similar) en la que hubiera coherencia formal entre música e imagen. Se dio plena libertad en la elección de tema, estética visual, parámetros musicales representados, tipo de música... y se fomentó la originalidad en los planteamientos. Los vídeos resultantes se vieron y analizaron colectivamente en clase y también se expusieron públicamente en una pantalla de televisión ubicada en uno de los accesos a la Facultad de Ciencias de la Educación coincidiendo con la Exposición de cotidiáfonos “Se ruega tocar” en la que se mostraban trabajos también realizados por los alumnos de la misma asignatura.
How is it Done? : Comparison between the Margin Calculation Methodology of Central Counterparties and Clearinghouses
Authors: Friesz Melinda , Váradi Kata
Published: September 2021

Clearinghouses and central counterparties have become the backbone of financial markets by stepping between trades, facilitating securities trading, and derivative transactions on exchanges and overthe-counter markets. In the literature and in practice, too, the notion of clearinghouse and central counterparty are used as synonyms, but there is still a slight difference that highlights their distinction. This paper focuses on the margin calculation methodology of these institutions and emphasizes the contrast between the two. Results show that although capturing the same risks, clearinghouses’ margin requirement is better from a procyclicality and cash flow management point of view; however, central counterparties margining is more prudent based on our results.
The Contribution of ESG Information to the Financial Stability of European Banks
Authors: Tóth Balázs , Lippai-Makra Edit , Szládek Dániel , Kiss Gábor Dávid
Published: September 2021

Nowadays more and more economic actors publish information regarding sustainability, through economic (E), social (S), and governance (G) performance. In the case of banks, ESG performance is important as they affect most of the industries through their investments and loans. In this research our aim is to investigate the relationship between financial stability and ESG performance. We applied panel regressive methods during the analysis. The sample consisted of stock exchange listed lending institutions (243 banks) from the European Union (EU) and the European Free Trade Association (EFTA). Our results show that ESG performance reduced the ratio of non-performing loans significantly. Furthermore, the positive effect of regulatory capital has been confirmed. Consequently, we can assert that the economic, social, and governance performance have beneficial impacts on financial stability. Therefore, the consideration of these pieces of information should be important for the investors and the regulators as well.
UTILIZAÇÃO DE ISOTRETINOÍNA ORAL NO TRATAMENTO DA ALOPECIA FIBROSANTE FRONTAL: SÉRIE DE CASOS
Authors: Caroline Suassuna Araújo Neuza , e Vasconcelos do Egypto Lívio
Published: September 2021

Introdução: A alopecia fibrosante frontal (AFF) é considerada uma alopecia linfocítica primária de caráter crônico, sendo descrita também como um tipo de alopecia cicatricial. Clinicamente, é comum o paciente acometido por tal patologia apresentar recessão frontotemporal da linha do cabelo, frequentemente acompanhada por perda de sobrancelha. Embora tenha um padrão clínico bem característico, ainda não se sabe ao certo sua patogênese, existindo diversas hipóteses para tal distúrbio patológico. O prognóstico para casos dessa natureza é fundamentado pelo estágio em que se encontra. Destaque-se, que não há, ainda, um tratamento específico para a AFF. Objetivo: Nesta direção, a presente pesquisa objetivou, em linhas gerais, avaliar os efeitos terapêuticos da utilização da isotretinoína oral em pacientes que foram diagnosticadas com alopecia fibrosante frontal. Método: Para o estudo ora apresentado, realizou-se uma descrição de uma série de casos, caracterizando-se, pois, como um estudo observacional de caráter descritivo, com abordagem de natureza qualitativa. As informações foram obtidas por meio de entrevistas e de coleta de dados dos prontuários dos pacientes, com autorização expressa, por escrito, mediante assinatura do Termo de Consentimento Livre e Esclarecido (TCLE), devidamente submetido ao Comitê de Ética em Pesquisa do Centro Universitário de Patos (UNIFIP). Resultados: Entende-se que este estudo poderá contribuir para melhor conhecimento acerca dos efeitos terapêuticos no curso clínico da utilização da terapia medicamentosa com isotretinoína oral em pacientes diagnosticados com AFF, com vistas a proporcionar auxílio aos profissionais especializados em relação à conduta medicamentosa que apresente resposta favorável à evolução clínica do paciente. Conclusão: O tratamento com isotretinoína oral e se mostrou eficaz, pois ocorreu a estabilização da alopecia. A perda capilar gera impacto na feminilidade dessas mulheres, sendo comum a relação da alopecia com baixa autoestima. Palavras chave: Alopecia fibrosante frontal; Isotretinoína; Efeitos terapêuticos.
UMA ANÁLISE QUALITATIVA SOBRE SEXUALIDADE E SEUS ASPECTOS BIOPSICOSSOCIAIS NA TERCEIRA IDADE
Authors: Pedro Arantes da Cunha João , Raphael Fujii Ramos Jordão , Vilela de Freitas Thiago , Franco Maciel Ruberval
Published: September 2021

Introdução: O aumento da expectativa e qualidade de vida transpassaram os significados de envelhecimento, levando à maior visibilidade da sexualidade e ocorrência de práticas sexuais na população idosa, tornando-as mais vulneráveis às infecções sexualmente transmissíveis (IST’s). Objetivo: Analisar o processo de construção de sentidos das idosas a partir dos aspectos de letramento em saúde, relacionando à temática da sexualidade e suas repercussões biopsicossociais. Métodos: Trata-se de uma pesquisa qualitativa de natureza interpretativa e exploratória realizada com um grupo de idosas em acompanhamento em um Centro de Doenças Infecto-contagiosas. Foi priorizada uma abordagem pós-estruturalista na epistemologia da emergência pós-moderna, voltando-se a perspectiva teórica para os estudos sobre letramento em saúde. Resultados: Destacam-se aspectos que emergiram: desejo sexual e impotência, comportamentos de risco inerentes às práticas sexuais apresentadas pelos idosos, baixo letramento acerca dos riscos aos quais estão expostos, negação pessoal com a prática sexual, seja por cunho religioso, ou relacionado às opiniões da família, medos e receios, a própria construção do senso comum e preconceitos perante a sexualidade do idoso exposto pela mídia. Conclusão: Em relação à quebra de círculo hermenêutico interpretativo, ocorreram crises em diversos pontos das conversas: a continuidade da sexualidade na terceira idade, o baixo retrato pela mídia, em relação ao conceito e percepção das práticas sexuais e prevenção das IST’s na terceira idade. O tema merece maior reconhecimento, já que a prática sexual é realizada universalmente, tornando-se uma problemática de saúde coletiva, tornando-se necessário alavancar ações e estudos de educação em saúde para a população idosa.

Palavras chave: Letramento em Saúde; Saúde do Idoso; Comportamento Sexual; Sexualidade; Doenças Sexualmente Transmissíveis; Saúde Pública.
IMPACT OF HYPOXIA AND INFECTION ON THE MORPHOLOGY OF THETHYROID GLAND
Authors: Yaqubova Samira
Published: September 2021

The investigation aimed to study the microscopic features of the thyroid gland under the influence of barochamber hypoxia and staphylococcal infection in the experiment. Materials and methods of the study. During the study 30 healthy adult male white rats weighing 180–200 g were used. Morphological features of the gland were studied by histological methods. Results of the study. Analysis of the study results shows that morphological changes occurring in the thyroid gland cells are more pronounced in animals of the infectious group than in animals of the hypoxia group. Thus, under the influence of infection, atrophic changes prevail in the gland tissue, and under the influence of hypoxia, hyperplasia, and hypertrophy, proliferation and differentiation of gland cells are observed. This can be considered a structural reconstruction of the gland tissue and its adaptation to new conditions.
THERAPEUTIC EFFECT OF SINGLET OXYGEN ADMINISTRATION ON CRYSTALLIZATION OF RATS’ BLOOD SERUM AT THERMAL TRAUMA
Authors: Martusevich Andrew , Perunova Agata , Karuzin Constantin , Bocharin Ivan , Nikolaeva Alexandra
Published: September 2021

Biological and therapeutic effects of singlet oxygen have not been investigated yet. The aim of this paper is to estimate the influence of a short course (10 days) of singlet oxygen inhalations on crystallogenic properties of rats’ blood serum. The experiment was performed on 30 male Wistar rats, randomly divided into three equal groups. The first group was intact. The animals of the 2nd (control) and 3rd (test) groups under combined anesthesia were subjected to thermal trauma. Starting from the day following the injury, the rats of the test group inhaled daily the air flow from a singlet oxygen generator during 10 days. Blood samples were obtained from the rats of all groups. Dried samples were evaluated visually for crystallizability, structure index, facia destruction degree, and marginal zone clarity, using respective scales. It is stated that singlet oxygen inhalations facilitate the elimination of negative transformations in blood crystallization induced by thermal trauma. It indicates the positive rehabilitation potential.
EMOTIONAL DISTRESS AS A RISK FA CTOR FOR CORONARY HEART DISEASE IN CLINICALLY HEALTHY MEN WITH ALEXITHYMIA
Authors: Kodochigova Anna , Bogdanova Tatyana , Psanukova Diana , Kirichuk Vyacheslav , Sinkeev Mikhail , Olenko Elena , Dzheyranova, Malakh , Blinova Victoria , Zankin Maxim , Semenova Valeria
Published: September 2021

Objective: To identify emotional distress as a risk factor for development of coronary heart disease (CHD) in clinically healthy males with alexithymia. Materials and methods: We examined 89 clinically healthy males (mean age — 43.7 [39.0; 43.5] years) using Ch. Spielberger–Yu.Khanina tests, S. Subbotin and the Toronto Alexithymic Scale (TAS). Results: It was found that more than half of the respondents can be associated with alexithymia or they had its obvious clinical manifestations. As the severity of alexithymia increased, there was an increase in the levels of personal anxiety and a decrease in stress resistance that may increase the risk of developing coronary heart disease. Conclusion. Therefore, clinically healthy males with alexithymia of varying severity need psychological support to increase the effectiveness of primary prevention of CHD.
THE DIAGNOSTIC ROLE OF FETAL HEMOGLOBIN AND BLOOD OXYGEN SATURATION IN CHRONIC LIVER DISEASES
Authors: Levitan Boleslav , Skvortsov Vsevolod , Kasyanova Тatiana , Vozniuk Maksim
Published: September 2021

This research aims to study levels of fetal hemoglobin and blood oxygen saturation in 264 patients with chronic diffuse liver diseases, among them 69 patients with chronic hepatitis and 195 patients with liver cirrhosis. To determine the levels of fetal hemoglobin, a patented method of rocket electrophoresis in agar gel with sodium dodecyl sulfate was used. The level of fetal hemoglobin in liver cirrhosis were significantly increased compared to chronic hepatitis, and, in both cases, compared with the control group. Oxygen saturation of the blood was reduced mainly in liver cirrhosis. In patients with liver cirrhosis a relationship between fetal hemoglobin and oxygen saturation was established. Our study helps in the early diagnosis of latent chronic hypoxia and hypoxemia in patients with liver disease. This allows to assess disease severity and adjust the treatment
ARCHAISMS OF JÁNOS ARANY, THE HUNGARIAN POET, AND THEIR TEACHABILITY
Authors: Lőrincz Gábor , Lőrincz Julianna , Tóth Szilárd Tibor
Published: September 2021

With the vocabulary and individual style of János Arany’s folk and historical verses and poems, the author contributed to the reform of the Hungarian literary language and style, and by doing so also to the codification of the Hungarian language. In the paper, the authors briefly describe archaisms, their typology, their function in the literary language, and take their examples from the works of János Arany. Within archaisms, the study also describes a group of archaic concepts, historisms, and their types. The authors also introduce a dictionary of the poetic language of Arany, which was published on the bicentenary of the poet’s birth, and also briefly allude to a few previous attempts to process Arany’s vocabulary. They use the AranySz. (Arany Dictionary) published in 2017 to study archaisms and expressions with important stylistic functions and the educational aspects thereof, mainly in the language of the ballads “A walesi bárdok” (‘The Bards of Wales’) and “Szondi két apródja” (‘The two varlets of Szondi’).
MORE ON THE STUDY OF THE FOLKLORE TRADITION OF KARELIANS
Authors: Mironova Valentina Petrovna , Ivanova Liudmila Ivanovna
Published: September 2021

The article is a review of scholarly works by Karelian folklore researcher, Cand. Sci. (Philology), Merited Scientist of Karelia Alexandra Stepanovna Stepanova. Her biography is briefly presented, the collecting and scientific activity of the researcher is examined, the contribution to the study of the Karelian lamentation tradition and folk culture as a whole is analyzed in the article. A. S. Stepanova made more than fifty expedition trips to the various regions of Karelia during her working at the ILLH KRC RAS, she recorded language and folklore-ethnographic material from representatives of all groups of Karelians living both in the Republic of Karelia and in the neighbouring territories. She is the author of a number of scientific collections, monographs and more than 50 articles. She introduced the samples of the Karelian lamentations into the scientific circulation for the first time, as well as their translations into Russian. A special merit of A. S. Stepanova consists in compiling the “Dictionary of the language of Karelian lamentations”, the appearance of which has set a new direction in Karelian science - linguistic folkloristics. Nowadays, the researcher’s scientific works stay relevant among the scientific community both in Russia and abroad. The honorary titles of a foreign corresponding member of the Society of Finnish Literature (Suomalaisen kirjallisuuden seura), of the Kalevala Society (Kalevalaseura), of the Finno-Ugric Society (Suomalais-ugrilainen seura) are the evidences of this. Scientific collections and anthologies on Karelian folklore are actively used for the study of the native (Karelian) language, oral folk art and folk culture in the universities and schools of the Republic of Karelia. In addition, Stepanova’s books are popular among all the people who express the interest in the folk culture.
WOMIDZ 'EVIL EYE' AS A PHENOMENON OF VERBAL MAGIC OF THE KOMI-ZYRYANS
Authors: Panyukov Anatolii Vasil`evich
Published: September 2021

Belief in the evil eye is among the rare universals of human culture, which still does not have a satisfactory explanation. The author proposes to focus on the traditional ideas of the Komi-Zyryans about the in the evil eye, which make it possible to assert their original verbal-magical character. The concept put forward by the author is based on the following definition is put forward by the author of the concept: “ Womidz is an unintentional, spontaneously induced verbal-magical effect with a negative result, due to the linguistic semantics of the word- womidz . The verbal component underlying the magical act can be expressed by direct speech or is associated with the verbalization by the addressee of unspoken thoughts and intentions of the addressere”. This provision is proved by the analysis of folk terminology and a wide range of phenomena characteristic of the notions of spoilage. According to the author's position, the verbal-magic act of vomidz can be presented in the form of a communicative model: addressere (sender of the word- womidz ) - verbal message (word- womidz ) - addressee (recipient of the message) and object of damage- womidz ; this object can be either the addressee himself or any object of vital importance to him, which is in the field of view.
A WORD ABOUT THE ASCETIC
Authors: Rogachev Vladimir Ilich , Stepin Sergei Nikolaevich
Published: September 2021

Review of the collective monograph: Scientist. Poet. Publicist: to the 85 anniversary of the birth and the sixtieth anniversary of the creative activity of V. M. Vanyushev: collective monograph / UdmFITSURO RAN; comp. and ed. by R. V. Kirillova. - Izhevsk, 2021. - 292 p. ISBN 978-5-6044266-8-5.
Hyperdentia in adult patient in the ENT practice
Authors: Fileva Lyubov V. , Baryshevskaya Lyudmila A. , Chernyshenko Inna O. , Zavalko Tatyana A. , Rodionova Svetlana V. , Zeleva Olesya V. , Kotova Yuliya D.
Published: September 2021

According to the literature, such dentition anomaly as supernumerary teeth is more common in the practice of a dentist than of an otorhinolaryngologist. Clinical manifestations of this pathology in adults are less frequent than in children. Periodically, there appear descriptions of individual cases of hyperdentia, in which the tooth is located in the nasal cavity, paranasal sinuses, orbit. It is not always possible to find such a tooth on examination, therefore, additional research methods help to determine the location and pathological process in more detail. We present our clinical observation of tooth retention and ectopia in the nasal cavity and upper jaw. The diagnosis was confirmed by the data of endoscopic examination and computed tomography of the paranasal sinuses. The ectopic tooth was found before the development of pronounced local inflammation. The tooth was removed from the nasal cavity using endoscopic techniques, no communication between the nasal cavity and the oral cavity was found. The postoperative period was uneventful. On examination two weeks after the operation, no pathological changes in the nasal cavity, paranasal sinuses were found, as well as defects in the mucous membrane and bone part of the nasal cavity floor.
Accelerated aging and psychological age of an individual as risk factors for COVID-19 complications
Authors: Berezina Tatyana N. , Yakovats Elizaveta A. , Faskhutdinova Yuliya F. , Rybtsov Stanislav A.
Published: September 2021

Objectives to study the effect of psychological age on the risk of severe forms of Covid-19 in adults.
Material and methods. Research method: natural experiment. The 1st measurement: indicators of biopsychological age - mid-2020, the 2nd measurement: assessment of Covid-19 disease - the end of 2020. Subjects: 239 people aged 35-70 (155 women). Methods for assessing psychological age, expected retirement age, biological age, and analysis of variance were used.
Results. Indicators of the relative psychological age of an individual affect the development of the disease and its severity, while the combination of low indicators of psychological age with high biological indicators is most dangerous and increases the likelihood of developing severe forms of the disease.
Parameters of functional activity in elderly and senile women with polymorbidity and risk of sarcopenia
Authors: Kurmaev Dmitrii P. , Bulgakova Svetlana V. , Zakharova Natalya O.
Published: September 2021

Objectives to identify the correlations between the Charlson comorbidity index and the results of functional activity tests as predictors of sarcopenia among elderly and senile women with polymorbidity. Material and methods. The study included 269 elderly and senile women aged from 65 to 84 years, having polypathology. Results. Sarcopenia was detected in 14.63% of the elderly, and in 27.40% of senile women. The Charlson comorbidity index was associated with the risk of progression of frailty, a decrease in basic functional activity, increased muscle weakness and impaired function of skeletal muscles. Conclusion. Dynamometry and functional activity tests can be used in clinical practice to diagnose sarcopenia syndrome in elderly and senile women.
The risk of burnout syndrome in medical professionals under the impact of working conditions and psychological climate in the team
Authors: Yeliseeev Yurii Yu. , Ratushnaya Neilya Sh. , Eliseeva Yuliya V.
Published: September 2021

Objective to assess the risk of developing the burnout syndrome in medical workers under the influence of working conditions and psychological environment in the team.
Material and methods. To evaluate the level of emotional burnout, 134 medical workers of medical institutions of the Saratov region were tested according to Viktor Boiko methodology, based on the study of the working environment and the labor process, as well as according to Fiedlers methodology of assessing the psychological climate in the team.
Results. The study results testified the direct influence of the factors of the labor process that determine the class of working conditions on the risks of developing emotional burnout in medical workers. The 2.0 class of working conditions implies the risk of occupational burnout in 30.7% of doctors after five years of work. The 3.2 class of working conditions leads to burnout in 46.7% of doctors after five years of work.
Discussion. The high degree of emotional burnout registered in medical workers in the course of this study was naturally determined by both the level of the class of working conditions and the level of the psychological tension in the team. The prognosis of burnout syndrome development in the teams with positive psychological climate is 20.0%, while in the teams with unfavourable psychological situation the risk of occupational burnout reaches 46.6%.
Conclusion. The results obtained in the course of this study were used as the basis for the development of a method for predicting the risk of developing burnout syndrome in medical professionals.