bluuebunny/crossref_metadata_2025 huggingface dataset:
Intensification of Invasive Fungal Infections and Exploration of Effective Antifungal Drug Delivery Formulations: A Detailed Review
Authors: Sharma Shrikant Mahesh , Sharma Rupali , Chandrateya Pankaj
Published: December 2024

Invasive fungal infections (IFIs) pose a significant global health threat, particularly among immunocompromised individuals. These infections can lead to severe illness and death, placing a significant financial burden on healthcare systems. Fungi were not previously considered a substantial risk to human health, but this perception changed with the rise of the HIV epidemic. The emergence of drug-resistant fungal strains further complicates the man-agement of these infections, highlighting the urgent need for effective antifungal therapies. Addressing this challenge requires innovative approaches and antifungal drug delivery for-mulations as promising strategies. This article explores the role of effective antifungal drug delivery formulations in combating the rise of IFIs. These formulations, ranging from lipid-based systems like liposomes and lipid emulsions to polymeric nanoparticles and micropar-ticles, offer several advantages over conventional drug delivery methods. Optimizing these formulations may improve drug efficacy, reduce the risk of drug resistance, and enhance pa-tient outcomes. Furthermore, advancements in nanotechnology and targeted drug delivery systems hold promise in overcoming existing limitations and expanding the scope of antifun-gal therapies.
Annual SZ: An Alternative Immunotherapy for COVID-19 and Long COVID
Authors: Heidari Fatemeh , Farahighasreaboonasr Faranak , Mohammad Hassan Zuhair , Fazeli Pooria , Hosseini Maryam , Ebtekar Masoumeh
Published: December 2024

Since the outbreak of coronavirus disease 2019 (COVID-19) in late 2019 and early 2020, the identification of drugs to control severe acute respiratory syndrome coro-navirus 2 (SARS-CoV-2) infection and its symptoms has been a pressing focus of research. Cytokine storm and acute respiratory distress syndrome (ARDS) are the leading causes of mortality following infection. In this review, we discuss immune pathogenesis and four medications, including Remdesivir, Tocilizumab, Dexamethasone, and Annual SZ for COVID-19. A comparison of the effectiveness and therapeutic usage of drugs as reported in clinical trials and reports was made at different disease levels as well. Clinical studies indicate that Annual SZ with mild side effects was more affordable and might be more effective than other medications. Additionally, Annual SZ was capable of reducing the lev-els of pro-inflammatory cytokines as well as viral attachment and RNA replication.
Corrigendum to: Highly Efficient Bimetallic Catalyst for the Synthesis of N-substituted Decahydroacridine-1,8-diones and Xanthene-1,8-diones: Evaluation of their Biological Activity
Authors: Atkore Sandeep T. , Raithak Pranita V. , Vijay Kotra , Ansari Siddique A. , Ansari Irfan A. , Varala Ravi
Published: December 2024

The author has identified an error in the department of the authors in the article titled “Highly Efficient Bimetallic Catalyst for the Synthesis of N-substituted Decahydroacridine-1,8-diones and Xanthene-1,8-diones: Evaluation of their Biological Activity” published in Current Organic Synthesis, 2024, 21(3) [1].

Details of the error and a correction are provided here.

ORIGINAL

1. SANDEEP T. ATKORE

Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, 431004, Maharashtra, India

2. PRANITA V. RAITHAK

Department of Clinical Biochemistry, Dr. Baba Saheb Ambedkar Marathwada University, Aurangabad, 431004, Maharashtra, India

CORRECTED

1. SANDEEP T. ATKORE

Department of Biochemistry, Dr. Baba Saheb Ambedkar Marathwada University, Aurangabad, 431004, Maharashtra, India

2. PRANITA V. RAITHAK

Department of Botany, Dr. Baba Saheb Ambedkar Marathwada University, Aurangabad, 431004, Maharashtra, India

We regret the error and apologize to readers.

The original article can be found online at: https://www.benthamscience.com/article/136681
Microcirculation conditions and its influence on ventricular remodeling in patients with arterial hypertension and lower extremity arteries atherosclerosis
Authors: Statsenko M. E. , Guzenko D. S. , Dudchenko G. P. , Verle O. V.
Published: December 2024

Objective: to evaluate the feature of microcirculation condition and left ventricle remodulation type in patients with arterial hypertension (AH) and lower extremity arteries atherosclerosis (LEAA).

Materials and methods: one hundred patients from 45 to 65 years old were included in this research. The main group consisted of 50 patients with arterial hypertension and lower extremity arteries atherosclerosis and the control group included 50 patients with AH and without LEAA. Laser doppler flowmetry and echocardiography were performed for all patients.

Results: there were lower values of microcirculation index (26,54[10,51–29,25] vs 37,3[26,59–40,24], р=0,0001), Am (0,25[0,22–0,32] vs 0,36[0,35–0,48], р=0,001) и Аe (0,47[0,42–0,47] vs 0,50[0,50–0,58], р=0,001), capillary reserve (134,5[126,7–151,8] vs 166,4[153,2–166,4], р=0,001). Breathe test index (41[17,93–77,74] vs 47,7[19,93–47,76], р=0,013) and higher value of bypass indicator (1,95[0,63–2,26] vs 1,31[1,13–1,31], р=0,0001) in patients with arterial hypertension and lower extremity arteries atherosclerosis compared to patients with isolated AH. Spastic (46% vs 14% р=0,0002) and spastic–atonic (30% vs 0%, р=0,0001) microcirculation types were reliably more often in main group compared to control group, whereas normal (0 vs 38%, p=0,0001) and stagnant (24% vs 48%, р=0,001) types were reliably rare. Concentric (62% vs 38%, р=0,004) and eccentric (8% vs 0%, р=0,0001) left ventricle hypertrophy (LVH) were found veraciously more frequently in patients with arterial hypertension and LEAA than in patient with AH and without LEAA. The binary logistic regression model was performed. It was determined that LVH risk was higher due to microcirculation index and capillary reserve decreasing in patients with arterial hypertension and lower extremity arteries atherosclerosis.

Conclusion: spastic and spastic–atonic microcirculation types were reliably more often in main group compared to control group Endothelial disfunction, decreased tissue perfusion increased microcirculatory bypass and blood stagnation were detected in patients with AH and LEAA compared to patients with isolated AH. Concentric and eccentric left ventricle hypertrophy were found veraciously more frequently in patients with arterial hypertension and LEAA than in patient with AH and without LEAA and the risk of LVH was depended on microcirculation index and capillary reserve in patients of the main group.
Dynamic Augmented Reality Cues for Telementoring in Minimally Invasive Surgeries: Scoping Review
Authors: Hamza Hawa , Aboumarzouk Omar M , Al-Ansari Abdulla , Navkar Nikhil V
Published: December 2024

Background

Remote surgeons use telementoring technologies to provide real-time guidance during minimally invasive surgeries (MIS). Such technologies are continuously improving with the integration of dynamic augmented reality (AR) cues. This includes virtual overlays of hand gestures, pointers, and surgical tools onto the operating surgeon’s view. The operating surgeon comprehends this augmented information to operate on the patient. Thus, understanding these dynamic AR cues (either during surgical training or live surgery) is crucial.

Objective

In this paper, we aimed to review the existing telementoring technologies that use dynamic AR cues during MIS. This review describes the MIS (including surgery type, specialty, procedure, and clinical trial), the telementoring system, the dynamic AR cues generated by these systems, and evaluation of the technology in terms of technical aspects, user perceptions, skills gained, and patient outcomes.

Methods

A scoping review was conducted using PubMed, Web of Science, Scopus, IEEE Xplore, and ACM Digital Library databases. The search terms included “telementoring,” “minimally invasive surgery,” and “augmented reality” without restrictions imposed on the publication year. Articles covering telementoring using dynamic AR cues during MIS, including laparoscopic and robot-assisted, were identified.

Results

A total of 21 articles were included and categorized based on type of surgery, the telementoring technology used, and evaluation of the technology. Most of the articles reported on laparoscopic suturing performed using synthetic phantoms. Hand gestures and surgical tools were the most frequently used dynamic AR cues (10 articles on each cue), while the mentors and mentees primarily consisted of experienced surgeons and medical students. The studies assessing the telementoring technologies were either descriptive (7 articles) or analytical (14 articles) where it was compared against no cue, prerecorded visual cue, in-person guidance, audio cue, or static AR cue. Outcomes were measured mostly using skills gained (13 articles) and user perception about the telementoring system.

Conclusions

In general, telementoring using dynamic AR cues resulted in positive outcomes during MIS. In some cases, they were considered on par with conventional methods such as audio cues and in-person guidance. Further randomized controlled trials are required to objectively assess its clinical benefits.
The impact of hydrogen-rich water consumption to acute and residual fatigue after simulated football match: Study protocol for randomized, double blinded, placebo-controlled parallel trial (Preprint)
Authors: Hruby Michal , Hulka Karel
Published: December 2024

BACKGROUND

IFootball matches induce acute and residual fatigue, impairing neuromuscular, metabolic, and perceptual performance. Hydrogen-rich water (HRW) is a novel intervention with antifatigue and antioxidative properties.

OBJECTIVE

This study will investigate the effects of pre-exercise HRW administration versus placebo on performance, biochemical markers, and perceptual measures of fatigue during a 72-hour recovery after a simulated football match.

METHODS

Utilizing a randomized, double-blinded, placebo-controlled, parallel design, elite junior football players underwent assessments of repeated sprint ability, countermovement jump performance, and biochemical indicators (e.g., creatine kinase levels). Testing will be conducted immediately post-match and at 24-, 36-, and 72-hour intervals. Pre- and post-exercise HRW/placebo was administered under standardized conditions.

RESULTS

This study will assess the influence of molecular hydrogen to acute fatigue manifestation and recovery quality during 72-hour after simulated football match. We expect recruitment to begin during the spring of 2025, data analysis in the summer of 2025, and results by the end of 2025.

CONCLUSIONS

The possible positive effect of molecular hydrogen would speed up the players' readiness to train after the match.

CLINICALTRIAL

This in not clinical study.
"AI that’s so good it almost seems human": An App Review on the Risk and Hype Cycles of AI and
Chatbots in Mobile Mental Health Apps (Preprint)
Authors: di Bona Katherine , Ijaz Kiran , Ahmadpour Naseem
Published: December 2024

BACKGROUND

Interactive AI, such as conversational agents (CAs), is increasingly incorporated into digital mental health mobile apps, offering new ways to support users. As such, there is a need to understand the trends surrounding this evolving innovation landscape.

OBJECTIVE

In this study, we aim to assess and identify key themes in claims around the efficacy and utility of interactive AI features such as CAs in mental health perpetuated by mobile app developers and compare those to consumer experiences.

METHODS

We conducted an app review analysing 14 mental health apps, selected out of 320 apps featured on the Google Play Store that claimed to include interactive AI features, performing a qualitative analysis of their app descriptions and user reviews.

RESULTS

Thematic analysis identified four themes: (i) exaggerated claims by app developers in a saturated market promise “powerful” solutions with AI, (ii) apps as profit-driven platforms often aim to monetise user-centric mental health services through deceptive tactics, and (iii) foster user dependency, and (iv) the human appeal of CAs is often used excessively to attracts users, despite technical limitations and potential harm of overt humanism in CA.

CONCLUSIONS

Our findings suggest that interactive AI and CAs hold potential for mental health care, however require stricter regulatory oversight and more considered design to prioritise user needs effectively. We therefore advocate for safety-focused design, guided by frameworks such as Safety by Design, alongside stricter regulations, to ensure these tools are responsibly developed and centred on user needs.
Tavsiye Sistemleri Literatürünün Bibliyometrik Analizi
Authors: İlkhan Can , Önder Emrah
Published: December 2024

Bu çalışma, tavsiye sistemleri literatürünün son beş yılda gerçekleştirilen bibliyometrik analizini içermektedir. Web of Science (WoS) veri tabanından elde edilen veriler kullanılarak, bu alanın gelişimi ve dönemeç noktaları detaylı bir şekilde incelenmiştir. Tavsiye sistemleri, kullanıcı verilerini kullanarak kişiselleştirilmiş içerik ve ürün önerileri sunan teknolojilerdir ve bu sistemler, internetin ve dijital işlemlerin yaygınlaşmasıyla birlikte önem kazanmıştır. Kullanıcılar tarafından verilen doğrudan geri bildirimler veya göz izleme teknolojisi gibi yöntemlerle elde edilen zengin veriler, kullanıcı tercihlerinin analiz edilmesi ve ihtiyaçlara uygun önerilerin sunulması için kullanılmaktadır. Araştırma, GroupLens çalışması gibi önemli adımları ele alarak, işbirlikçi filtreleme ve içerik tabanlı filtreleme gibi temel yaklaşımların gelişimine ışık tutmaktadır. Bu sistemler, Google ve Facebook gibi platformlar tarafından kullanıcı etkileşimlerini analiz edip, gelecekteki tercihleri tahmin etmek amacıyla kullanılmaktadır. Bibliyometrik analiz, VOSviewer aracılığıyla yapılan görselleştirmelerle desteklenmiş olup, tavsiye sistemleri literatüründe sıkça karşılaşılan terimlerin ve bu terimler arasındaki ilişkilerin detaylı bir haritasını sunmaktadır. Çalışma, bu alanda araştırma yapacak olanlara rehberlik edecek şekilde tasarlanmıştır ve tavsiye sistemlerinin bilimsel etkisinin arttığını göstermektedir. Bibliyometrik analiz, bilimsel yayınların niceliksel bir değerlendirmesini sağlayarak, bu yayınların bilimsel etki ve kalitesini objektif bir şekilde ölçmüştür. Analiz sonuçları, tavsiye sistemleri alanındaki akademik çalışmaların ve atıfların zaman içindeki artışını göstermektedir ve bu artış, alandaki ilginin ve etkinin giderek arttığını işaret etmektedir. Bu tür bir analiz, gelecekte bu konu üzerine çalışacak araştırmacılara yol gösterici olabilir ve tavsiye sistemlerinin daha da geliştirilmesi için temel oluşturabilir. Sonuç olarak, bu çalışma, tavsiye sistemleri literatürünün kapsamlı bir analizini sunmakta ve araştırma alanındaki bilimsel ilerlemeleri daha derinlemesine inceleme imkanı sağlamaktadır.
Scopus Veri Tabanında İşgörenlerde Mobbing Konulu Çalışmalara İlişkin Bibliyometrik Analiz İncelemesi
Authors: Yavuz Ercan , Sabur Dilek Gökçen , Demirel Mustafa Abdüssamed
Published: December 2024

Araştırmanın amacını bibliyometrik analiz türü kullanılarak, Scopus veri tabanında yer alan işgörenlerde mobbing konulu çalışmaların incelenmesi oluşturmaktadır. Bu kapsamda araştırmada betimsel özellik gösteren tarama modeli kullanılmaktadır. Tarama modelinde nicel araştırma yöntemi olan bibliyometrik analizinden faydalanılmıştır. Scopus veri tabanı olarak tercih edilmiştir ve 25.05.2024 tarihinde veri tabanı üzerinde “mobbing” ve “employee” kelimelerinin yer almasına ilişkin bir tarama gerçekleştirilmiştir. Bu bağlamda araştırmanın evrenini dünya üzerinde işgörenlerde mobbing kavramıyla ilişkili yapılmış çalışmalar oluşturmaktadır. Araştırmanın örneklemini ise, Scopus veri tabanında bahsedilen anahtar kelime başlığında, arasında “başlık (title), “anahtar kelime (keywords)” ve “abstract (özet)” olarak kullanılan çalışmalar meydana getirmektedir. Elde edilen verilerin görsel analizinde Vosviewer istatistik programından yararlanılmıştır. Tarama kapsamında bu anahtar kelimeler ile ilgili 1984 ile 2024 yılları arasında 241 mevcut çalışmaya ulaşılmıştır. Anahtar kelime analizi neticesinde zorbalık ve iş yeri zorbalığı, çatışma, işgören ilişkileri ve depresyon ifadelerine rastlanmıştır. Anahtar kelimeler arasında yer alan zorbalık, çatışma ve işgören ilişkileri kelimelerinin en fazla tercih edilen anahtar kelimeler olarak tercih edilmesi, mobbingin tanımında sıklıkla kullanılmalarından kaynaklanmaktadır.
Turist Deneyimi, Güdüler, Memnuniyet ve Hikâye Anlatıcılığının Demografik Değişkenlere Göre İncelenmesi: Kapadokya Örneği
Authors: Kemerci Murat , Karaca Şükran
Published: December 2024

Turizm deneyimleri öznel doğalarıyla karakterize edilen kişisel olaylar olduğu için her tüketicinin deneyimi algılama biçimi, bireysel özelliklerine göre değişmektedir. Özellikle demografik değişkenler ve önceki deneyimler turistlerin algılarını etkilemektedir. Aynı zamanda deneyimler seyahatten önce, seyahat sırasında ve seyahatten sonra meydana gelen karşılaşmaların neden olduğu bir dizi bilişsel ve duygusal etkiyi içermektedir. Turistlerin bireysel özellikleri destinasyonlarda yaşadıkları deneyimleri anlatılar yoluyla başkalarıyla paylaşmalarını şekillendirmektedir. Dolayısıyla deneyimler ve hikâye anlatıcılığı turistlerin bireysel özelliklerine, varış noktası unsurlarıyla etkileşimlerine ve çevredeki durumsal faktörlere bağlı olarak farklılık göstermektedir. Bu bağlamda çalışmanın amacı, turist deneyimi, güdüler, memnuniyet ve hikâye anlatıcılığının katılımcıların demografik özelliklerine göre anlamlı bir farklılık gösterip göstermediğini tespit etmektir. Bu kapsamda Kapadokya / Nevşehir destinasyonunu tercih eden 591 kişiden çevrim içi anket tekniği ve kolayda örnekleme yoluyla veriler elde edilmiştir. SPSS programı aracılığı ile güvenilirlik ve geçerlilik analizleri, normallik testi, Bağımsız Örneklem T testi ve Tek Yönlü Anova analizleri yapılmıştır. Yapılan analizler sonucunda; turist deneyimi, hedonik ve faydacı güdüler, memnuniyet ile hikâye anlatıcılığının medeni durum, yaş, meslek, eğitim ve gelir durumuna göre farklılık gösterdiği, cinsiyete göre ise farklılık göstermediği tespit edilmiştir. Elde edilen sonuçlar doğrultusunda paydaşlara çeşitli önerilerde bulunulmuştur.
Điều kiện cần và đủ cho cận sai số phi tuyến
Authors: Đoàn Hữu Hiệu , Trương Thành Trung , Võ Minh Tâm , Nguyễn Duy Cường
Published: December 2024

Bài báo thiết lập điều kiện cần và đủ cho cận sai số phi tuyến của hàm thực suy rộng trong không gian mêtric và Asplund. Các điều kiện được trình bày dưới dạng độ dốc và dưới vi phân Fréchet riêng phần thông qua các kỹ thuật của giải tích biến phân hiện đại. Các kết quả được vận dụng để nghiên cứu cho tính chính quy mêtric phi tuyến của ánh xạ đa trị.
Nghiên cứu tổng hợp polycaprolactone triol hình sao làm nguyên liệu tổng hợp polyurethane định hướng ứng dụng trong y sinh
Authors: Huỳnh Đại Phú , Trần Đức Mạnh , Mai Hữu Xuân , Nguyễn Thị Kim Phượng
Published: December 2024

Trong nghiên cứu này, polycaprolactone triol (stPCL) hình sao đã được tổng hợp thành công thông qua phản ứng trùng hợp mở vòng của ε-caprolactone (CL), sử dụng glycerol làm chất khởi đầu và Sn(Ot)2 làm chất xúc tác. Khối lượng phân tử của stPCL được xác định bằng phương pháp sắc ký gel (GPC,) nằm trong khoảng 1.600Da. Cấu trúc của stPCL được xác định bằng phổ cộng hưởng từ hạt nhân (1H-NMR) và quang phổ hồng ngoại biến đổi Fourier (FTIR). Sản phẩm stPCL này được sử dụng làm nguyên liệu chính để tổng hợp polyurethane (PU) nhiệt rắn định hướng ứng dụng trong lĩnh vực y sinh.
Phân lập và tuyển chọn các chủng vi khuẩn có tiềm năng phân hủy nhựa polystyrene (PS) từ đất bãi rác trên địa bàn thành phố Cần Thơ
Authors: Huỳnh Ngọc Thanh Tâm , Nguyễn Nguyễn Văn Khởi , Đinh Đinh Ngọc Bích , Lê Lê Trần Y Khoa , Dương Dương Thanh Nhựt Lâm , Trần Trần Thị Thu Trang , Huỳnh Huỳnh Yến Nhi
Published: December 2024

Polystyrene (PS) là loại nhựa nhiệt dẻo được sử dụng phổ biến với những đặc tính tiện lợi và giá thành rẻ. Tuy nhiên, lượng rác thải từ loại nhựa này đang ngày càng gia tăng ở mức đáng báo động và gây ra những tác hại đến môi trường cũng như sức khỏe con người. Nghiên cứu này nhằm mục đích phân lập và tuyển chọn các chủng vi khuẩn có khả năng phân hủy nhựa PS trong điều kiện phòng thí nghiệm. Nghiên cứu cho thấy, 15 chủng vi khuẩn phân lập có thể tồn tại trong môi trường Basal salt medium có bổ sung 0,1% bột nhựa polystyrene. Hai chủng CT26 và CT10 chỉ phát triển sinh khối mạnh tại vị trí có đặt tấm nhựa polystyrene trên môi trường thạch. Đồng thời, hai chủng vi khuẩn này có khả năng làm giảm khối lượng bột nhựa lần lượt là 42,12% và 34,08% sau 28 ngày nuôi cấy trong môi trường lỏng. Kết quả giải trình tự gene 16S rRNA cho thấy hai chủng CT26 và CT10 được xác định lần lượt là Cronobacter sakazakii và Pseudomonas aeruginosa với độ tương đồng đạt lần lượt là 99,85% và 100%.
Khảo sát thành phần ký sinh trùng trên cua biển (Scylla paramamosain) nuôi quảng canh ở tỉnh Cà Mau
Authors: Nguyễn Thị Thu Hằng , Đặng Thụy Mai Thy , Trần Thị Mỹ Duyên , Nguyễn Bảo Trung , Châu Tài Tảo , Trần Thị Tuyết Hoa
Published: December 2024

Nghiên cứu được tiến hành nhằm tìm hiểu mầm bệnh ký sinh trùng trên cua biển nuôi quảng canh ở tỉnh Cà Mau. Kết quả đã xác định được 7 giống ký sinh trùng trong mang, máu, gan tụy và khoang cơ thể cua biển: Acineta, Epistylis, Hematodinium, Octolasmic, trùng lông Peniculida, giun tròn Nematoda và Portunion. Các giống ký sinh trùng có chỉ số đa dạng Shannon: 0,8. Giống Portunion ký sinh trong khoang cơ thể của cua biển làm cho cơ bị tiêu biến và làm thay đổi đặc điểm sinh dục thứ cấp. Kết quả kiểm tra 83 mẫu có 82 mẫu bị nhiễm ký sinh trùng. Ấu trùng Portunion có tỷ lệ nhiễm cao nhất (86,7%) trên mang cua biển. Tỷ lệ nhiễm trứng và ấu trùng Portunion trong gan tụy đạt 100% ở cua biển tại huyện Đầm Dơi. Tỷ lệ nhiễm Portunion trưởng thành là 27,7%, tuy nhiên, cường độ nhiễm Portunion trưởng thành ở huyện Năm Căn (5,7 trùng/cua) cao hơn so với nơi khác. Cường độ nhiễm trứng và ấu trùng của Portunion cũng ở mức cao, lần lượt là 33,8 và 24,1 trùng/lame. Giống Hematodinium có cường độ nhiễm cao nhất (86,5 trùng/lame).
Khảo sát hoạt tính chống oxy hóa và kháng viêm in vitro của dịch chiết ngoại bào vi khuẩn nội sinh phân lập từ cây mảnh cộng (Clinacanthus nutans)
Authors: Lý Khôi Nguyên , Trần Chí Linh , Đái Thị Xuân Trang
Published: December 2024

Mục tiêu nghiên cứu là phân lập vi khuẩn nội sinh (VKNS) có khả năng sinh tổng hợp các hợp chất chống oxy hóa và kháng viêm ở cây Mảnh Cộng (Clinacanthus nutans). Hoạt tính chống oxy hóa của dịch chiết ngoại bào (DCNB) từ VKNS được đánh giá qua hàm lượng polyphenol, flavonoid tổng số, khả năng trung hòa gốc tự do DPPH, khả năng chống oxy hóa tổng số và năng lực khử. Khả năng kháng viêm được xác định qua ức chế sự biến tính của albumin huyết thanh bò. Kết quả đã phân lập được 24 dòng VKNS có khả năng sinh tổng hợp các hợp chất polyphenol ngoại bào, chống oxy hóa và kháng viêm. Hàm lượng TPC từ 94,32 đến 2284,44 mg GAE/mL DCNB, TFC từ 5,35 đến 99,69 mg QE/mL DCNB. Khả năng chống oxy hóa bởi phương pháp DPPH, RP và TAC từ 0,13 đến 1067,36 mg vitamin C tương đương/mL DCNB. Hàm lượng chất kháng viêm từ 0,32 đến 0,46 mg diclofenac tương đương/mL DCNB. Ba dòng VKNS có hoạt tính cao đồng đều ở các chỉ tiêu khảo sát là Bacillus sp. CN-R1, Enterobacter sp. CN-R15 và Enterobacter sp. CN-L7.
Ảnh hưởng của độ kiềm lên tăng trưởng và tỷ lệ sống của tôm sú (Penaeus monodon) giai đoạn ương giống bằng công nghệ biofloc
Authors: Huỳnh Hoàng Sơn , Châu Tài Tảo
Published: December 2024

Nghiên cứu nhằm xác định độ kiềm thích hợp lên tăng trưởng và tỷ lệ sống của tôm sú (Penaeus monodon) giống ương theo công nghệ biofloc, thí nghiệm gồm 4 nghiệm thức độ kiềm: 80, 120, 160 và 200 mgCaCO3/L. Tôm giống có khối lượng 0,01 g/con được bố trí vào bể composite có thể tích 250 L, độ mặn 15‰, mật độ ương 2.000 con/m3 và rỉ đường được sử dụng để tạo biofloc với tỷ lệ C:N = 10:1. Sau 28 ngày ương, các yếu tố môi trường đều nằm trong phạm vi thích hợp cho tôm sinh trưởng và phát triển tốt. Thể tích biofloc dao động từ 2,89 đến 3,12 mL/L, cao nhất ở nghiệm thức 160 mgCaCO3/L (3,12±0,09 mL/L) và khác biệt không có ý nghĩa thống kê (p>0,05) giữa các nghiệm thức. Khi kết thúc thí nghiệm, tôm ở nghiệm thức 120 mgCaCO3/L có tăng trưởng (4,03±0,01 cm/con, 0,44±0,017 g/con), tỷ lệ sống (90,2±2,12%) và sinh khối (1.803±43 con/m3) cao nhất, khác biệt có ý nghĩa thống kê (p<0,05) so với các nghiệm thức còn lại. Như vậy, ương giống tôm sú theo công nghệ biofloc ở độ kiềm 120 mgCaCO3/L là tốt nhất so với các nghiệm thức còn lại.
The Development of Disaster Risk Map for Semeru Volcano Eruption 2021-2022, East Java, Indonesia
Authors: Bachri Syamsul , Sanjaya Eli Hendrik , Sendari Siti , Shrestha Rajendra Prasad , Irawan Listyo Yudha , Billah Egi Nursari , Putri Nanda Regita , Prastiwi Mellinia Regina , Hakiki A.Riyan Rahman , Hidiyah Tabita May
Published: December 2024

The Semeru Volcano eruption on December 4, 2021 caused damage to social, economic and environmental aspects. The Rejali Watershed (DAS) is one of the areas severely affected due to the eruption. The eruption resulted in 51 deaths, 10,565 displaced people, 1,027 houses damaged, two connecting routes and 43 public facilities damaged. This study mapped the disaster risk areas due to the eruption of Semeru Volcano. This research used Laharz to analyze the lava flow hazard map and weighting for social, economic, physical, environmental, and capacity vulnerability parameters. The results showed that the risk level of Semeru Volcano eruption is divided into three classes: high,  medium, and low risk. The high-risk area is 8915.09 Ha (14 %), the medium-risk area is 2174.74 Ha (17 %), and the low-risk area is 1885.60 Ha (69%). The high and medium risks were located on the upper and middle slopes of the Rejali watershed because the upstream area experiences a narrowing of the river flow (bottleneck) due to direct borders with structural land. The Semeru Volcano disaster risk map results can be used as a reference in sustainable risk management efforts in the Rejali watershed to reduce the impact and damage caused by the eruption.
Customary Laws and Land: Changes in Landholding System of the Karbis in Assam, India
Authors: Engtipi Rashmi , Dhanaraju Vulli
Published: December 2024

The purpose of this study is to look into the evolving trends in the landholding system of the Karbi tribe in Assam, India, as well as the nature of the customary laws that govern their land. This study challenged the Western notion of land ownership, which frequently promotes individual ownership and private ownership. The present study supported the idea of tribes’ customary rights over land management and communal property. Qualitative data were collected through field observations and oral interviews. This study employed content and discourse analysis methods to interpret the materials gathered. This research can be summarized by arguing that, with changing dynamics, the relationship is becoming clearer as survival dependency transitions from shifting cultivation to settled agriculture. Hill tribes have yet to gain legal entitlement to property in many regions, despite farming it for decades under communal ownership. The rise of private land rights is creating a situation in which more educated members of the society are abusing customary laws for personal gain. The landholding systems of the tribes in India, particularly the hill tribes of Assam, have been overlooked in studies for many decades. These overlooked research findings will contribute to the current knowledge and understanding of land management systems.
Clinical Relevance of Computational Pathology Analysis of Interplay between Kidney Microvasculature and Interstitial Microenvironment
Authors: Chen Yijiang , Wang Bangchen , Demeke Dawit , Fan Fan , Berthier Celine , Mariani Laura , Lafata Kyle , Holzman Lawrence , Hodgin Jeffrey , Janowczyk Andrew , Barisoni Laura , Madabhushi Anant
Published: December 2024

Key Points

There is a modulatory effect between peritubular capillaries (PTCs) and areas of interstitial fibrosis and tubular atrophy (IFTA).

The spatial architecture of non-IFTA PTCs on the cortex is significantly associated with glomerular disease progression.

The shape of IFTA PTCs on the cortex is significantly associated with glomerular disease progression.

Background

Interstitial fibrosis and tubular atrophy (IFTA) and density and shape of peritubular capillaries (PTCs) are independently prognostic of disease progression. The aim of this study was to identify novel digital biomarkers of disease progression and assess the clinical relevance of the interplay between a variety of PTC characteristics and their microenvironment in glomerular diseases.

Methods

A total of 344 Nephrotic Syndrome Study Network/CureGN participants were included: 112 with minimal change disease, 134 with focal segmental glomerulosclerosis, 61 with membranous nephropathy, and 37 with IgA nephropathy. A periodic acid–Schiff–stained whole-slide image per patient was manually segmented for cortex, pre-, and mature IFTA. Interstitial fractional space (IFS) was computationally quantified. A deep learning model was applied to segment PTCs. Spatial and shape PTC pathomic features (230) were extracted from the cortex, IFTA, and non-IFTA subregions. Participants were divided into training and testing datasets (1:1). Univariate models incorporating IFTA subregions and IFS-PTC density were constructed. Least absolute shrinkage and selection operator regression models were used to identify the top PTC features associated with disease progression stratified by IFTA and non-IFTA subregions. Machine learning models were built using the top PTC features in IFTA and non-IFTA subregions to prognosticate disease progression.

Results

PTC density in pre+mature IFTA and IFS, shape features in pre+mature IFTA, and spatial architecture features in the non-IFTA regions were associated with disease progression. The machine learning–generated risk scores showed a significant association with disease progression on the independent testing set.

Conclusions

We uncovered previously under-recognized digital biomarkers of disease progression and the clinical relevance of the complex interplay between the status of the PTCs and interstitial microenvironment.
The Effects of Flipped Learning-Based Learner-Centered Instruction on Nursing Students' Communication Skills, Problem-Solving Abilities, and Self-Directed Learning Skills
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kwak MyungHee , Ko JeongA
Published: December 2024

Objectives The purpose of this study is to determine the effects on nursing students' communication skills, problem-solving skills, and self-directed learning skills by applying the flipped learning teaching method for learner-centered classes.
Methods The subjects of the study were 85 students enrolled in their third year of nursing at a university, and data collection was a single-group comparative study with a pre-post design for a 15-week course in the second semester of 2023. SPSS Window version 23.0 was used for the collected data, and the difference between before and after the experiment was tested using Paired t-test.
Results Nursing students' communication ability, problem-solving ability, and self-directed learning ability are positively correlated, and as a result of applying the flipped learning-based teaching method, communication ability (t=4.13, p= <.001) and problem-solving ability (t=2.65, p=.010) was improved and there was a statistically significant difference.
Conclusions It was confirmed that learner-centered flipped learning classes have an impact on the communication and problem-solving abilities of nursing students, and it is necessary to confirm learning outcomes by applying flipped learning in various subjects in the future.
Structural Relationships between Game Time, School Adjustment, and Academic Achievement of Elementary, Middle, and High School Students
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Jeong-Soo , Kim Yun-Young , Lee Seung-Yeon , Choi Won Seok
Published: December 2024

Objectives The purpose of this study is to analyze the impact of students' game usage time on school adjustment and academic achievement and to clarify the structural relationships between them.
Methods Using data from the Gyeonggi Education Panel Study (GEPS), this study analyzed the structural relationships between game usage time, school adjustment, and academic achievement of students in the 6th grade of elementary school, 2nd grade of middle school, and 2nd grade of high school using a structural equation model. Additionally, differences between groups were analyzed based on game usage time.
Results Students' game usage time negatively impacted school adjustment and academic achievement. School adjustment positively influenced academic achievement, with the impact increasing from elementary to high school. Game usage time negatively affected academic achievement through the mediation of school adjustment. The influence of game usage time on school adjustment and academic achievement varied by school level and game usage time groups.
Conclusions The longer the students' game usage time, the lower their academic achievement tends to be, with game usage time indirectly negatively impacting academic achievement through the mediation of school adjustment. In elementary school, game usage of less than 3 hours per day, and in middle school, 1-2 hours per day did not significantly negatively impact academic achievement. However, in high school, all game usage times negatively impacted academic achievement.
A Study on the Influence of Counselors’ Critical Consciousness on the Multicultural Counseling Competences: The Mediating Effect of Multicultural Counseling Self-efficacy
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kwak Youn Jeong , Choi Na-Yeun
Published: December 2024

Objectives This study aims to establish and verify a structural equation model of the variables related to critical consciousness, multicultural counseling self-efficacy, and multicultural counseling competence.
Methods The participants of this study were selected on the basis that they obtained bachelor’s degrees or higher in counseling and psychology and who have worked as counselors in institutions with multicultural education. A total of 233 data was analyzed with SPSS 27 and AMOS 29.
Results All variables showed significant positive correlations. Model identification was based on goodness of fit and χ2 difference test criteria. This study compared a partial mediation (research) model with a full mediation (alternative) model, based on theoretical foundations. The partial mediation model was ultimately selected. The mediating effect of multicultural counseling self-efficacy was found to be significant.
Conclusions Multicultural counseling self-efficacy demonstrated a partial mediating effect between critical consciousness and multicultural counseling competence. When utilizing critical consciousness to enhance multicultural counseling competence, it would be beneficial to apply it in conjunction with self-efficacy. This study provides a foundation for counselors to incorporate critical consciousness into multicultural counseling competence development training, which is considered to be its significant contribution.
The Effect of Teachers' Empathy and Professional Development Levels on Teacher-Young Child Interactions
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Park Min Hee , Kwack Kyeong Hwa
Published: December 2024

Objectives The purpose of this study is to investigate the effect of teacher’s empathy ability and professional development level on teacher-young child interactions.
Methods The purposes of this study, we surveyed 320 young children teachers working at public, workplace, private, and home daycare centers located in G City from January 2, 2024 to January 26, 2024. For the collected data, Pearson's correlation analysis was performed to analyze the correlation between each variable using the SPSS 21.0 program, and multiple regression analysis was performed to analyze the influence of the variables.
Results The analysis results are as follows. First, it was found that there was a high correlation between variables among young children teachers' empathy ability, level of professional development, and teacher-yound child interaction. Second, as a result of analyzing the influence of the young children teacher's level of empathy and professional development on teacher-young child interaction, knowledge and skill development, self-understanding development, and cognitive empathy were found to have a significant influence on the overall teacher-young child interaction.
Conclusions Through this study, we sought to find ways to increase the empathy and expertise of young children teachers by examining the variables that affect the teacher-young child interaction and the level of empathy and professional development of young children teachers, and to foster positive interactions between teachers and young children. It can be basic data to improve operation.
Implementation, Difficulties, and Demands of Childcare Respect for Infant Rights by Beginning Childcare Teachers
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Yoon Su-Been , Hwang In-ae
Published: December 2024

Objectives In this study, the experience of the beginning childcare teacher's implementation of respecting infant rights in daycare centers was examined, and difficulties and demands in the implementation process were explored.
Methods For this study, 10 beginning childcare teachers with less than three years of experience who worked at daycare centers in Daegu/Gyeongbuk were interviewed, and journals of researcher and research participants and documents related to respecting infant rights were collected and analyzed.
Results The implementation of respecting the rights of infant by beginning childcare teachers was divided into providing initiative in daily routine, activities to recognize the rights of infant, and implementation respecting infant rights in connection with families. Also, Difficulties in the process of implementation respect for the rights of infant by beginning childcare teachers were divided into a set daily operations and work burdens, excessive demands and distrust from parents, and difficulties as low-experience teachers. In addition, The demand for the improvement of childcare for respecting infant rights was divided into laying the foundation for the practice of childcare for respecting infant rights, revitalizing education for respecting infant rights, and supporting considering the characteristics of beginning childcare teachers.
Conclusions This study is meaningful in that by exploring the experiences of beginning childcare teachers on children rights-respecting childcare, it understands how beginning childcare teachers practice children rights-respecting childcare and the difficulties and demands they experience in the process of implementation. Based on this, it is expected that the beginning childcare teachers, who will start their childcare positions in the childcare field, will be provided as basic data to come up with support measures to practice higher-quality infant rights-respecting childcare.
Team-based learning effectiveness in a basic nursing science pathology class
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Ahn Mina
Published: December 2024

Objectives This study aimed to confirm the effects of applying the team-based learning method on self-directed learning ability, achievement motivation, learning attitude, and communication skills in basic nursing courses.
Methods The participants in this study were 78 second-year nursing students enrolled in pathology classes, and the study utilized a one-group pretest-posttest design to assess the effects of applying the team-based learning method over six weeks. Data analysis was conducted using SPSS-WIN 26.0, with the reliability of the scales calculated using Cronbach’s α. The general characteristics of the participants were analyzed using frequencies and percentages, and the effectiveness of the team-based learning method on the dependent variables was assessed using paired t-tests.
Results After applying the team-based learning method, self-directed learning ability (t = -2.878, p = .005) showed a statistically significant improvement. Among the subdomains of achievement motivation, the adventurous spirit (t = -3.329, p = .001) also improved significantly. Additionally, in the learning attitude subdomain, the self-concept regarding subjects (t = -3.737, p < .001) improved significantly. However, there was no statistically significant difference in communication skills.
Conclusions The team-based learning method has been shown to help improve self-directed learning ability in nursing students studying foundational courses. Future research is recommended to confirm its effectiveness across various departments and academic years.
Big Data-based 2022 Revised Physical Education Division Analysis of Research Trends on Curriculum Policy
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Ham Ji-sun
Published: December 2024

Objectives The purpose of this study is to examine the research trends of academic research materials related to the 2022 revised physical education curriculum policy using big data-based text mining techniques.
Methods For this purpose, a total of 77 academic data were collected by web crawling of academic papers containing ‘2022 Revised Physical Education and Curriculum’ in the database (RISS) provided by the Korea Education and Research Information Service, and the collected data were analyzed using text mining analysis methods such as word frequency, TF-IDF, and LDA analysis.
Results The results are as follows: First, as a result of the keyword frequency analysis of the studies of the 2022 revised physical education curriculum policy, ‘education’, ‘research’, ‘physical education’, ‘curriculum’, ‘analysis’, and ‘learning’, ‘Utilization’, ‘class content’, ‘sports’, and ‘curriculum’ appeared as key keywords related to the revised physical education curriculum, and they could be visualized through the word cloud. Second, as a result of conducting topic modeling analysis based on big data of papers related to the 2022 revised physical education curriculum policy, a total of three major topics for each research trend were derived: ‘content-oriented research on the 2022 revised physical education curriculum by area’, ‘research on support and development for future physical education classes’, and ‘research on the content and method of fostering creative personality’.
Conclusions Through the above results, we were able to reflect on the results of our research so far, and furthermore, we were able to explore and suggest the direction of future research.
The Impact of ARCS Motivation Strategies through Digital Learning Tools on Online Learning Continuance Intention and Achievement: The Mediating Role of Course Satisfaction
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Hyewo n Cho
Published: December 2024

Objectives The study aimed to examine the mediating role of course satisfaction between motivation strategies and learning effects by applying structural equation modeling.
Methods 310 undergraduates using digital learning tools in an online class participated in this study. While the students attended a synchronous online class, they participated in motivational activities using digital learning tools throughout the semester and were asked to answer surveys in the last week of the semester. The suitability of the measurement model was evaluated through confirmatory factor analysis using the measured variables, and the structural model and indirect effects were tested.
Results The analyses revealed the effectiveness of motivation strategies on course satisfaction and the indirect effects of motivation strategies on learning continuation intention and achievement. The Attention, Relevance, and Satisfaction strategies positively influenced learning effects, mediated by course satisfaction, but the Confidence strategy had no significant impact. The Attention strategy showed the strongest indirect effect on learning effects, while the Satisfaction strategy showed the weakest effect.
Conclusions The results supported the ARCS model's impact and confirmed the paths between motivational processing and outcome processing. The importance of motivational strategies and course satisfaction was highlighted to promote learning effects, suggesting the need for instructional methods to enhance positive learning outcomes. In addition, the usefulness of digital learning tools in ARCS motivational activities was discussed.
Analysis of domestic research trends on middle school student delinquency: Comparison of before and after corona in academic journals published in April 2015-2024
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Jung Jungwon , Jeon Hyojeong
Published: December 2024

Objectives By analyzing the research trends on middle school delinquency before and after the coronavirus, focusing on KCI-registered journals in Korea, we aim to provide directions for intervention and prevention in future middle school delinquency research through research implications and suggestions.
Methods To this end, we searched for ‘youth delinquency’ published in Korea from 2015 to April 2024 and papers dealing with middle school students' delinquency with the keywords of middle school students. 56 of the 190 middle school student flight papers were reviewed, and trends by period and academic field, data collection and data analysis trends, and trends by research variable were analyzed according to the analysis criteria.
Results First, As a result of examining by research period, it can be seen that 11 studies were conducted in 2015, and then 3-4 studies were conducted, and from 2021, 9 studies have been continuously conducted with a rapid increase. Second, when looking at the collection of research data, it can be seen that most of the studies were based on panel data in post-COVID-19 studies, unlike pre-COVID studies that used panel data from various institutions. The Korean Children and Youth Panel was the most frequently used phenal data before and after COVID-19, and it was used in 41 of 56 studies. Looking at the analysis method, most of the studies used the regression analysis series the most, and in pre-COVID studies, there was one potential growth model and one program development after COVID-19. Third, in the research variable on middle school student delinquency, there were many studies on various types of variables for cyber flight during flight, and other detailed analysis was conducted by dividing them into individual variables, family and parents, schools and peers
Conclusions This study is significant in that it systematically organized 10 years of research on juvenile delinquency in middle schools into pre- and post-corona periods. We hope to provide suggestions for future research and a basis for further research.