bluuebunny/crossref_metadata_2025 huggingface dataset:
DYES IN FOOD AND DRUGS ARE POTENTIAL IMMUNOMODULATORS
Authors: Aliakhnovich N. S. , Novicov D. K.
Published: May 2019

There are some data about various immunopathology effects of food dyes. Their use in food and medicines may induce hypersensitivity, which is regarded as a side effect of drugs or intolerance to food substances. Evaluation of the effect caused by food and drugs colorants on the immunity was conducted in 68 patients with chronic allergic diseases without the exacerbation and 23 healthy individuals. The provocative oral test was supplied with 2 mg of titanium dioxide (TiO2) in powder or 2 mg of tartrazine in wheat flour processed at a cooking temperature or in a gelatin capsule containing 0.2 mg of titanium dioxide. The oral fluid and/or venous blood were taken up on an empty stomach and 40 minutes after the test. The peroxidase activity of oral fluid and the expression of CD203c and IgE markers on blood basophils were studied. The blood of 20 patients with allergopathology was incubated for 3 and 24 hours with 0.001% and 0.01% mixture of tartrazine, carmoazine, ponso, sanset, TiO2solutions with the determination interleukin 17 (IL17) level in the supernatants. Peroxidase activity of oral fluid increased on 30% or more in 30% of cases after tartrazine and wheat flour provocation in patients with allergies (12.5% in healthy persons), 44% - after TiO2in patients with allergies (22% of cases in healthy individuals), 63% - after tartrazine and TiO2in the white gelatin capsule in patients with allergies (in healthy individuals, p = 0.047). The number of IgE+CD203c+basophils increased in 44% cases and decreased in 50% cases after provocation with TiO2in the group of allergic patients, compared with 22% increasing and 22% decreasing in healthy (p = 0.007). A lower concentration of the dye mixture (0.001%) induced IL17 secretion in the supernatant in all 20 patients with allergic diseases, the maximum permissible concentration (0.01%) of the dyes solution - less often in 40% of the examined (p = 0.0002). Secretion of IL17 under the influence of the both concentrations was higher than in the control samples (p <0.05). Thus, the dyes of food and drugs show immunomodulatory activity in patients with allergic diseases (more often) and in healthy individuals. The connection of a positive provocation test with food dyes tartrazine and titanium dioxide with oral fluid peroxidase activity increasing and the number of IgE+CD203c+basophils and IgEbrightbasophils increasing and IL17 secretion under the influence of these dyes was found.
IDENTIFICATION OF BIOMARKERS OF RENAL PARENCHYMA DAMAGE IN THE URINE OF PATIENTS WITH CHRONIC PYELONEPHRITIS BY ELISA AND MASS SPECTROMETRY METHODS
Authors: Zakharova N. B. , Pastushkova L. Kh. , Lakh R. V. , Larina I. M. , Nikolaev E. N. , Ponukalin A. N. , Varaksin N. A. , Оficerov V. I. , Kononikhin A. S.
Published: May 2019

We performed clinical observations and laboratory examination of 22 patients with chronic pyelonephritis (chronic renal failure, CRF) and 30 healthy individuals. The patients with CRF were examined twice. The first group (Group I) included patients with exacerbation of the disease. The comparison series (Group II) was represented by the same patients who were examined 1.5-3 months after completion of treatment, without clinical exacerbation of chronic pyelonephritis (CPN). Laboratory signs of acute renal damage were not detectable in all the patients examined. Concentrations of VEGF, MCP-1, IL-8 and IL-18 were determined in urine samples of all examined persons by ELISA technique. Protein spectrum of urine was assessed in six patients from Group I, and in six cases of Group II by means of mass spectrometry, using Agilent 1100 chromatographic device, and LTQ-FT Ultra hybrid mass spectrometer. The results of parallel determination of urine proteins by the two methods have shown that the evolving CPN exacerbation is associated with local secondary immune deficiency at the level of renal tubular urothelium. Determination of urine proteome by means of mass spectrometry in exacerbating disease allows identify the proteins associated with damage to epithelial lining of renal tubules and development of local immune response.
PRİMER İZOLE BİLATERAL FETAL HİDROTORAKSIN TEKRARLAYAN TORASENTEZLE BAŞARILI TEDAVİSİ
Authors: YAKUT Hakan , ONAT Taylan , BAŞER Emre , KARA Mustafa , YALVAÇ Ethem Serda
Published: May 2019

Bu sunumumuzda nadir bir
durum olan bilateral fetal hidrotoraks olgusunu, literatür ile birlikte gözden
geçireceğiz. Fetusa 33. gebelik haftasında tanı konmasından sonra, toplam 5
kere torasentez işlemi yapıldı. Hasta son adet tarihine (SAT)  göre 40 hafta 3 günde normal doğum yaptı.
İntrauterin torasentez yapılan bebek 56 gün hastanede yattıktan sonra taburcu
edildi. Bu sunumda fetal hidrotoraks vakalarına genel bir literatür taramasıyla
torasentez işlemi ve kısaca diğer tedavi yöntemlerini sunacağız ve fetal
akciğerde biriken sıvının etyolojisini ve sonuçlarını gözden geçireceğiz.
Using Probabilistic Neural Networks to Predict the Localization of Proteins in Cell Compartments
Authors: Nazin P.S. , Gotovtsev P.M.
Published: May 2019

This paper describes the use of probabilistic neural networks to solve problems of bioinformatics by the example of determining the localization of proteins according to their primary structure. The data used are sets
of characteristics of amino acid sequences of proteins, obtained by various software tools aimed at finding specific signal sequences, as well as data on where these proteins are localized in cells of
two microorganisms — E. coli and S. cerevisiae. The data source is the UCI Machine Learning Repository (http://archive.ics.uci.edu/ml/datasets).
The possibility of using probabilistic neural networks to solve this problem is shown, since the classification accuracy of 57.5% and 85.0% for yeast and for bacterial cells is obtained, respectively.
The obtained indicators of the accuracy of the classification of the data used exceed those that, according to the literature, were achieved with the use of other recognition methods. It is noted that a high
learning rate and the possibility of modification make probabilistic neural networks a promising tool for analyzing bioinformatics data.
In silico
SAFETY AND EFFICACY OF PERCUTANEOUS NEPHROLITHOTOMY FOR THE TREATMENT OF PAEDIATRIC UROLITHIASIS: A SINGLE CENTER EXPERIENCE
Authors: Mahmood Sarwar
Published: May 2019

Background 

Children are more prone to the recurrent stone formation. To treat these cases, a procedure with a high success rate, less morbidity and the short convalescent period is needed. Percutaneous nephrolithotomy (PCNL) has become a well-established procedure for the management of renal calculi that are not amenable to (ESWL) in children of all age groups. 

Objectives 

We report our center experience and outcome of pediatric percutaneous nephrolithotomy (PCNL).

Patients and Methods

This prospective data analysis of 109 consecutive patients under the age of 17 who underwent PCNL from September 2009 to January 2016. All PCNL procedures were performed in prone position by a single experienced faculty urologist under general anesthesia and under fluoroscopic guidance. Rigid nephroscope was used. 

Results

One hundred and sixteen PCNLs were performed on 109 patients (six patient had bilateral PCNL), (65 boys and 44 girls), with a mean (range) age 6.57±4.51 (1-17) years, and mean (range) stone size was 2.341±1.105 (0.6-6) cm. Stones were complex staghorn stones in (16 cases), multiple stones in (51 cases) and single stones in (48 cases). Stones were present in complex anatomy included malrotated kidney (2 cases), previously treated pelviureteric junction obstruction (2 cases) and previously treated renal stones by open pyelolithotomy in 14 cases. Two tracts were made in six (5.1) cases, due to the large stone burden. Stone-free rate after PCNL monotherapy was 93%, which increased to 96.5% after shock wave lithotripsy, and it was significantly lower in complete staghorn stones (75 %). In the current study, 25 (21.72%) procedures were noted to had intraoperative/ postoperative complications and most of them (92%) were minor and all were managed conservatively.

Conclusion

PCNL in children is an effective and safe procedure for managing simple as well as complex renal calculi.
BRITISH EXPERIENCE OF SOCIAL AND PSYCHOLOGICAL REHABILITATION OF PEOPLE WITH DISABILITIES
Authors: Udovenko J. , Honcharenko O.
Published: May 2019

The article is devoted to the study of the UK experience with the system of social and psychological rehabilitation of people with disabilities. The legislation analyzes the protection and support of people with disabilities in the UK, which enables them to maximize their potential, live a full and active life in their families, communities and society as a whole. The content of the concept of "rehabilitation", defined in normative documents, is disclosed as a personalized, interactive and collaborative process that reflects a person as a whole, enabling her to maximize their potential, to live a full and active life in their family, community, educational activities, and the workplace where it is needed. The goals of social rehabilitation of people with disabilities in the UK are considered, namely the orientation towards the person, its needs, and not the diagnosis; active involvement process, not passive care; integration of specialized and universal services; maximizing the potential of personality; work in partnership etc.

The model of socio-psychological rehabilitation of people with disabilities in Great Britain, based on a multidisciplinary approach, is presented. The principles and stages of this model are described, aimed at implementation of complex, individually oriented approaches and active involvement of people with disabilities in different spheres of activity according to their needs and possibilities.

The experience of British organizations that implement innovative technologies of physical, financial, informational support of people with disabilities is studied and described, in particular: the system of "contactless physiotherapy", independent personal payments, special online applications for various events of soplife, etc.

The model of employment support for people with disabilities is presented in detail, which involves finding a job in accordance with the client's capabilities, training and adaptation to the workplace, and the general support of the work program for 2 years.
SOCIAL AND COMMUNICATION SKILLS AS THE LEADING MECHANISM FOR THE FORMATION OF PARTNERSHIPS OF STUDENT YOUTH
Authors: Ternopolskaya V.
Published: May 2019

The article analyzed peculiarities of development social and communicative skills of students as a leading mechanism for establishing partnerships. Outlined that affiliate interaction in the "student – student" system based on the relationships that provide equality of partners in the perception of each other, the orientation of subjects to the recognition of the value of the thoughts of everyone. Noted that successful formation of social and communicative skills possible provided in the educational process modeled organizational and pedagogical forms interpersonal interaction and communication. Outlined that organizational and pedagogical forms of interpersonal interaction through real experience and relevant activities of would encourage students to the detection of them social and communicative skills in daily life. Revealed that auditor and nonauditing activities must be a value-oriented character and makes on the basis of subject-subject partner interaction of participants in the educational process.
Correlación entre los valores del índice de masa corporal y las subescalas del Manchester Foot Pain and Disability Index en pacientes con fascitis plantar
Authors: García Vidal José Antonio , Baño Alcaraz Aitor , Sánchez Martínez María Piedad , Pascual Gutiérrez Roberto , Sánchez Marín Sergio
Published: May 2019

Objetivo:  determinar el impacto que sufren los pacientes con fascitis plantar crónica en relación a su Índice de Masa Corporal (IMC) basándonos en las subescalas incluidas en el Manchester Foot Pain and Disability Index (MFPDI) (“subescalas del dolor”, “subescalas de limitación funcional” y “subescala de discapacidad”). Material y métodos: Se realizó un estudio observacional transversal con 17 participantes diagnosticados de fascitis plantar crónica. Se administró el cuestionario MFPDI y se establecieron relaciones entre el resultado obtenido de las subescalas y el IMC. Resultados: Únicamente hay diferencias estadísticamente significativas entre las variables “Subescala de dolor” del MFPDI (p-valor = 0,013) y “Subescala de limitación funcional” del MFPDI (p-valor = 0,03) en relación a la variable IMC. Conclusión: El incremento del IMC tiene un efecto significativo en el nivel de dolor y limitación funcional según lo determinador por el MFPDI en pacientes con fascitis plantar.
Efectividad de los soportes plantares cómo tratamiento en el síndrome femoropatelar: revisión sistemática
Authors: Remón-Gallo Álvaro , Gómez-Bernal Antonio , Pérez-Morcillo Aitor , Alfaro-Santafé Javier
Published: May 2019

Objetivo: El objetivo principal de este trabajo es analizar la evidencia científica en relación a la efectividad de los soportes plantares para tratar el dolor femoropatelar.Material y métodos: Se realizó una búsqueda bibliográfica en cuatro bases de datos (Pubmed, Cochrane, Science Direct y Dialnet). Los términos empleados en la búsqueda fueron: patelofemoral pain syndrome, treatment, orthoses y orthotics. Se tuvieron en cuenta los artículos de los últimos 15 años que hablaran de soportes plantares a medida y prefabricados, que no combinaran las plantillas con otra terapia y que no fueran revisiones sistemáticas.Resultados: Se revisó un total de 10 artículos al completo. Tanto las ortesis a medida como las prefabricadas obtuvieron buenos resultados, aunque a largo plazo fueron mejores las plantillas a medida.Conclusión: Los soportes plantares son una buena alternativa al tratamiento del síndrome de dolor patelofemoral.
Evaluation of nephroprotective activity of Tinospora cordifolia against gentamicin induced nephrotoxicity in albino rats: an experimental study
Authors: Sharma Monica , Pundir Jyoti , Vishwakarma Pinki , Goel Raj Kumar , Saini Manish , Saxena K. K.
Published: May 2019

Background: Gentamicin induced nephrotoxicity is a major contributor to Acute Kidney Injury (AKI) resulting from free radicals induced oxidative stress. Tinospora cordifolia is an Indian medicinal plant, widely used because of its antioxidant activity. Due to limited scientific literature exploring its nephroprotective potential, the present study was designed to investigate the nephroprotective effect of aqueous extract of Tinospora cordifolia against gentamicin induced nephrotoxicity in albino rats.Methods: The study was commenced following approval from Institutional Animal Ethical Committee of L.L.R.M. Medical College, Meerut (UP). Twenty four rats were randomised into four groups of six animals each. Total duration of study was 21 days. Group I received normal saline p.o., group II received normal saline along with gentamicin on last 5 days, group III and IV received Tinospora cordifolia in graded doses p.o. along with gentamicin on last 5 days. Injection gentamicin (40mg/kg) i.p. was given once daily for last 5 days to induce nephrotoxicity in rats of groups II, III and IV. The rats were sacrificed under anaesthesia, blood samples analysed for blood urea nitrogen (BUN) and serum creatinine levels and histopathological changes were studied. Statistical analysis was done using ANOVA followed by post hoc test.Results: Tinospora cordifolia pre-treated groups exhibited significant (p<0.001) limitation in rise in levels of BUN and serum creatinine in a dose dependent manner. Histolopathological observations further corroborated the biochemical findings.Conclusions: The present study concluded that aqueous extract of Tinospora cordifolia possesses nephroprotective potential against gentamicin induced nephrotoxicity.
Management of urinary tract infections in children: antimicrobial sensitivity pattern, efficacy and pharmacoeconomics
Authors: Yadav Nikhil S. , Pathak Swanand S.
Published: May 2019

Background: Urinary tract infections are commonly seen in febrile children, high incidence of Vesico Ureteral Reflux (VUR) is frequently seen in paediatric patient which is of concern as it may lead to renal scarring. Despite presence of established clinical guidelines there is disparity amongst physician in the diagnosis and treatment of UTI, some physician prescribes taking into consideration the symptoms, some prescribe on the basis of smell and colour and some rely on urine culture and sensitivity report. There is dearth of studies in many tertiary health care centers regarding antimicrobial use. Authors conducted this study to evaluate antimicrobial sensitivity pattern, efficacy and cost effectiveness of antimicrobials used for UTI in children.Methods: Patients of urinary tract infection <13 years of age were included in the study. Symptoms of patient i.e. pain in abdomen, haematuria, increased frequency of urination and degree of fever were recorded. Efficacy was measured through calculating degree of defervescence per hour. Cost effective model was prepared by calculating cost effective ratio i.e. dividing cost of antimicrobial required to bring down the fever and degree through which fever came down.Results: E. coli was the most common pathogen isolated from urine positive culture (69.07%). Nitrofurantoin has shown highest sensitivity to all uropathogens (72.73%). Cotrimoxazole, ciprofloxacin and nitrofurantoin were found to be most cost effective.Conclusions: In this current study authors found E coli is the most common uropathogen isolated. Ceftriaxone, cefixime, cotrimoxazole and amikacin were found to be most efficacious. Cotrimoxazole, ciprofloxacin and nitrofurantoin were found to be most cost effective.
СРАВНЕНИЕ ИСП-МС АНАЛИЗА ГЕОЛОГИЧЕСКИХ ОБРАЗЦОВ В ВАРИАНТЕ РАСТВОРОВ И ЛАЗЕРНОЙ АБЛЯЦИИ СТЕКОЛ
Authors: Николаева Ирина Викторовна , Палесский Станислав Владиславович , Карпов Александр Викторович
Published: May 2019

Актуальность исследования связана с необходимостью опробования нового эффективного способа пробоподготовки геологических образцов, подходящего для массового многоэлементного ИСП-МС анализа, снижающего общие временные затраты и обеспечивающего возможность определения широкого набора элементов в рамках одного измерительного цикла с применением лазерной абляции (ЛА-ИСП-МС). Цель исследования состоит в сравнении метрологических характеристик двух методик ИСП-МС анализа, основанных на разных способах пробоподготовки силикатных пород – переведении твердого образца в раствор после сплавления с метаборатом лития и использовании готовых боратных стекол для ЛА-ИСП-МС анализа. Объекты: международные и отечественные стандартные образцы состава естественных горных пород: базальты – BHVO-1, BHVO-2, BCR-2, граниты – СГ-1а, СГ-3, габбро СГД-1а, трапп СТ-1а. Методы: масс-спектрометрия с индуктивно-связанной плазмой (ИСП-МС), лазерная абляция с масс-спектрометрическим окончанием (ЛА-ИСП-МС). Результаты исследования показали, что разработанные методики многоэлементного ИСП-МС и ЛА-ИСП-МС анализа позволяют определять широкий набор элементов в геологических образцах в рамках одного измерительного цикла в высоком, среднем и низком разрешении при использовании для внешней градуировки стандартных образцов с аналогичной матрицей и внутреннего стандарта для учета и снижения матричного влияния и дрейфа приборных параметров. Правильность определения всех элементов в соответствии с разработанными методиками доказана сравнением результатов анализа шести стандартных геологических образцов с принятыми значениями. ЛА-ИСП-МС отличается экспрессностью за счет отсутствия стадии пробоподготовки, при этом пределы обнаружения и погрешность определения для ЛА-ИСП-МС методики выше, чем при ИСП-МС анализе растворов.
МАТЕМАТИЧЕСКОЕ МОДЕЛИРОВАНИЕ РЕЖИМОВ РАБОТЫ КОЛЕБАТЕЛЬНОЙ ШАРОВОЙ МЕЛЬНИЦЫ
Authors: Данекер Валерий Аркадьевич
Published: May 2019

Актуальность настоящего исследования обусловлена необходимостью создания высокоэффективного ресурсосберегающего оборудования, применяемого при дроблении и измельчении рудного материала в горнодобывающей промышленности. Одним из путей создания такого оборудования является применение шаровых мельниц колебательного типа, в конструкции которых используется тяговый электромагнит переменного тока. Подключение тягового электромагнита к источнику напряжения переменной частоты позволяет регулировать режимы работы шаровой мельницы в широких пределах и обеспечивать её работу в квазирезонансных режимах. Математическое моделирование режимов работы шаровой мельницы колебательного типа позволяет определить требования к параметрам колебательной системы при варьировании частоты и величины питающего напряжения и разработать практические рекомендации, которые следует учитывать при проектировании промышленных образцов. Кроме этого, функционирование шаровой мельницы колебательного типа в квазирезонансных режимах сопровождается существенным сокращением энергозатрат при увеличении производительности.  Цель исследования: разработка математической модели шаровой мельницы колебательного типа при питании тягового электромагнита от источника напряжения переменной частоты; на основе разработанной математической модели провести расчёты режимов работы шаровой мельницы колебательного типа и сформулировать практические рекомендации для использования при проектировании шаровой мельницы. Методы. Математическое моделирование режимов работы шаровой мельницы проводилось на основе численного решения системы дифференциальных уравнений движения элементов колебательной системы. Параметры колебательной системы определялись расчётным путём с учётом реальных технических характеристик выпускаемого аналогичного оборудования. Результаты. Математическая модель шаровой мельницы колебательного типа позволяет определить диапазоны тяговых усилий и частот напряжения питания тягового электромагнита, соответствующие квазирезонансному режиму работы при изменении параметров колебательной системы. На основе установленного диапазона квазирезонансных частот и масс элементов колебательной системы могут быть определены параметры тягового электромагнита, конструкция и параметры пружинного подвеса шаровой мельницы.
ОПРЕДЕЛЕНИЕ ПОЛОМОК РЕЗЦОВ PDC С ПОМОЩЬЮ РЕГРЕССИОННОГО И НЕЙРОСЕТЕВОГО МОДЕЛИРОВАНИЯ
Authors: Третьяк Александр Яковлевич , Кузнецова Алла Витальевна , Борисов Константин Андреевич
Published: May 2019

Актуальность. В процессе бурения скважин буровые долота, армированные пластинами PDC, отрабатывают свой ресурс не полностью, так как часть режущих PDC элементов выходит из строя по причине их скола, слома или потери, что в значительной степени сказывается на конечных технико-экономических показателях бурения скважин. Цель: разработка и предложение нейросетевой модели для решения проблемы определения процента поломок режущих элементов буровых долот, армированных PDC, на основе имеющихся полевых данных бурения скважин по породам VI–VIII категории по буримости. Объекты: причины, вызывающие выход из строя пластин PDC на буровых долотах в процессе бурения скважин в породах VI–VIII категории по буримости в зависимости от режимных параметров бурения. Методы. В качестве факторов для определения процента поломок использовалась нагрузка на долото (P, кН), частота его вращения (N, об/мин) и скорость бурения (V, м/час) при неизменных значениях параметров промывочной жидкости и компоновки низа бурильной колонны. Для анализа данных применялись регрессионные и нейросетевые модели различных конфигураций. Результаты. Анализ регрессионных моделей показал их непригодность из-за нелинейного характера скорости бурения при низких давлениях и высоких оборотах. Авторами предложена двухступенчатая нейросетевая модель, в которой первая нейронная сеть (Neural Network) служит для определения скорости бурения, а вторая – для прогнозирования процента поломок пластин PDC. Ошибки нейросетевого ансамбля на тестовых данных не превышают величину пригодности нелинейных моделей, равную 4,5 % для относительной ошибки и 12–15 % для максимальной величины. Предложенная нейросетевая модель может найти применение при разработке технологического регламента отработки долот, армированных резцами PDC.
Bio-incidence and Bio-type of Mycobacterium avium subspecies paratuberculosis in diarrheic dairy cattle and buffaloes of Punjab area in India
Authors: Hassan Nuzhat , Randhawa Charanjit Singh , Narang Deepti , Singh Shoor Vir , Sharma Shukriti , Singh Swaran
Published: May 2019

Dairy cattle and buffaloes (n=101) suffering from chronic diarrhea (>3 weeks) with complete history of duration of diarrhea, systemic effects, body condition and faecal abnormalities were included in this study. Faecal samples, whole blood and rectal biopsies from selected animals were collected for the detection of Mycobacterium avium-subspecies paratuberculosis (MAP). Faecal smears were prepared and examined for the load of acid fast bacilli (AFB). Acid fast clumps were recorded in 40.6 per cent (41/101) of diarrheic animals and PCR confirmation was made byIS900 primers. MAP was detected in blood samples of four animals (4/41), while faecal samples were positive only in two of these 4 animals. All the four animals had persistent watery diarrhea and progressive loss in body weights and productivity. Rectal biopsies of two animals were positive by PCR. Remission of clinical signs was observed in these animals within 2-months. Biotyping of MAP-DNA from blood samples by IS1311 PCR-REA revealed restriction pattern of 67, 218 and 325 bp suggesting that MAP DNA belonged to ‘Bison type’, which is a major biotype infecting domestic livestock in India.
Clinical and Ultrasonographic examinations in cattle with empty rectum
Authors: Saravanan M. , Ranjithkumar M. , Yogeshpriya S. , Ravi R. , Kannan K.
Published: May 2019

Ultrasonography helps in early diagnosis of large animal digestive disorders especially in cattle with empty rectum and also to initiate early therapeutic and surgical management. The study was undertaken to elicit GI disturbances in cattle at TVCC, VCRI, Orathanadu during 2015-16. Animals with history of absence of feces and or empty rectum were selected for this study. In total twenty nine cattle were found to be affected with various GI disorders. The incidence of GI disturbances was more (65.52 %) in cross bred Jersey cow. The common clinical signs were absence of feces (65.52 %), anorexia (58.62 %), scant/tarry/mucous coated foul smelling feces (34.48 %), arched back (24.14 %) and abdominal distention (24.14 %). All selected 29 animals were subjected to abdominal ultrasonography which revealed peritonitis (31.03 %), paralytic ileus with peritonitis and pericarditis in each 10.34 %, uroabdomen, intussusceptions, caecal dilatation, abomasal dilatation and peritonitis with intussusceptions in each 6.90 % and diaphragmatic hernia, reticular abscess, omasal impaction and peritonitis with pericarditis in each 3.45 %. Based on this study, clinical and ultrasonographic examinations were found to be a useful tool for the diagnosis of GI disorders of cattle with empty rectum.
Surgical management of uterine torsion through ventral celiotomy in eleven mares
Authors: Khosa Jasmeet Singh , Anand Arun , Sangwan Vandana , Mahajan Shashi Kant , Mohindroo Jitendra , Singh Simrat Sagar
Published: May 2019

This article describes the surgical management of uterine torsion by midline celiotomy for cesarean section in 11 mares presented with signs of colic at a teaching veterinary hospital. The mares were either in full term of gestation (n = 6) or in advanced stage of pregnancy (n = 5). Majority of the mares (44.5%) were in fourth parity. 78% cases of uterine torsion were post cervical and clockwise and (22%) cases were post cervical and anticlockwise. For surgical intervention, mares were anesthetized using a combination of xylazine (1.1 mg/kg) and ketamine (2.2 mg/kg), intravenously and maintained on isoflurane inhalation anesthesia. Midline celiotomy was performed, and foals were delivered by cesarean section. Before closing the abdominal wound, the uterus was detorted manually and confirmed per-vaginally for its normal position. After long-term follow-up, the study reported 90.0% (10/11) survival rate out of which, seven were bred successfully.
Effect of seed priming on growth and seed yield in kabuli chickpea (Cicer arietinum L.) varieties
Authors: Shinde Pavan , Hunje Ravi
Published: May 2019

The field experiment was carried out at Water and Land Use Management Institute (WALMI) Farm, University of Agricultural Sciences, Dharwad during 2015-16 and 2016-17 to study the effect of seed priming on growth and seed yield in kabuli chickpea varieties. The experiment was laid in split plot design with three replications constituting two kabuli chickpea varieties and nine seed priming treatments. The results of pooled data revealed that, kabuli chickpea variety BG1105(V1) recorded significantly higher values for all parameters over MNK-1 (V2) while, seed priming with Sprint (Mancozeb 50% + Carbendazim 25% WS) @ 2 g per kg of seed (T9) recorded significantly higher chlorophyll content (53.45 SPAD value/plant) at 75 DAS, plant height (48.01 cm/plant), secondary branches (23.38/plant), number of pods (44.73/plant), seed yield (33.97 g/plant and 16.59 q/ha) compared other treatments and control (T1) (44.07 SPAD value/plant, 42.34 cm/plant, 17.98/plant, 32.25/plant, 19.95 g/plant, 12.09 q/ha, respectively) at harvest.
Influence of Rhizobium, Pseudomonas and Mycorrhiza on Some Physiological Traits of Red Beans (Phaseolus vulgaris L.) under different irrigation conditions
Authors: Seyahjani Ebrahim Abbasi , Yarnia Mehrdad , Farahvash Farhad , Khorshidi Benam Mohammad Bagher , Rahmani Hadi Asadi
Published: May 2019

This study was conducted to evaluate response red bean (CV. Goli) under drought stress conditions for three types of biological fertilizers in 2014 - 2015 years. A split plot experiment was conducted in Tabriz, Iran. Irrigation levels (irrigation after 70, 110, and 150 mm of evaporation from pan) were considered as main plots, and biological fertilizers Rhizobium (Rp), Mycorrhiza (My), Pseudomonas (Ps), Rp + My, Rp + Ps, Rp + My + Ps, and non-inoculation (control) were considered as sub plots. Combination of Rhizobium, Mycorrhiza, and Pseudomonas at irrigation level of more than 70 mm of evaporation had the highest grain yield, RWC, CCI, stomata conductance, leaf water potential and lowest cell leakage. Triple inoculation increased grain yield in comparison to the control, or to the time they were used individually or simultaneously; it also reduced the negative effects of drought stress on the beans.
Protein fractions as influenced by cultivars, stage of maturity and cutting dates in alfalfa (Medicago sativa L.)
Authors: Markoviæ Jordan , Petroviæ Mirjana , Terziæ Dragan , Vasiæ Tanja , Kostiæ Ivica , Štrbanoviæ Ratibor , Grubiæ Goran
Published: May 2019

This study was undertaken to determine the relationship between CNCPS (Cornell Net Carbohydrate and Protein System) protein fractions and in vitro RUP (Rumen Undegradable Protein) concentration and the variability of protein fractions among alfalfa cultivars grown in Serbia. Two cultivars of alfalfa (Medicago sativa L.) – Serbian cv K 28 and American cv G + 13R + CZ were sampled at three stages of maturity. Comparing the two cultivars of alfalfa (K 28 vs. G + 13R + CZ) means, there were significant differences in all protein fractions. Two investigated alfalfa cultivars differed significantly (p less than 0.01) in RUP content, cv G + 13R + CZ was higher in RUP than cv K 28. Stage of maturity had an effect on proportions of the protein fractions. From a nutritional and breeding point of view, cultivar such as G + 13R + CZ is desirable because it combine higher CP (Crude Protein) values with lower protein degradability than cv K 28.
Hospital Nurses' Perceived Patient Safety Culture and Adverse Nurse Outcomes in Korea
Authors: Choi Eun Wha , Kim Gi Yon , Shim Jae Lan , Son Youn-Jung
Published: May 2019

Background

Hospital nurses are likely to be the first to observe patient safety issues in clinical settings, and thus it is important to include their views on patient safety culture. However, there are few studies addressing the influence of nurses' perceived patient safety culture on adverse nurse outcomes as quality of care.

Purpose

This study was to identify the relationship between nurses' perceptions of patient safety culture and adverse nurse outcomes in Korea.

Methods

This cross-sectional study was included 299 nurses at two tertiary hospitals. Hierarchical linear regression was conducted to examine the impact of patient safety culture on adverse nurse outcomes among hospital nurses.

Results

The mean score of patient safety culture and adverse nurse outcomes were 3.50 out of 5 points and 3.07 out of 4 points respectively. In hierarchical linear regression, hospital work environment, the attitude of supervisor/manager, and hospital climate/culture of patient safety culture predicted adverse nurse outcomes after adjusting for general characteristics.

Conclusions

It is crucial for healthcare facilities to assess or evaluate their current patient safety culture perceptions on a regular basis. Furthermore, provision workshops and staff training on changing behaviors and perceptions regarding patient safety activities can improve nursing performance in clinical settings.
Design norms and live load development by the example of saint petersburg depot of reinforced concrete automobile road bridges
Authors: Belyi Andrei , Karapetov Eduard , Tsygankova Ekaterina
Published: May 2019

Objective: To analyze and cover the statistical data concerning the development and application of live load and relevant design standards by the example of Saint Petersburg bridge constructions. Methods: A comprehensive three-stage analysis of technical documentation on the operated reinforced concrete bridge constructions of the city was applied. Historical and technical review of norms and specifications of design, since the end of the 19th century was conducted. Systematization, statistical analysis and splitting into stages and groups were carried out. Results: The article presents the development of design standards and temporary loads of reinforced concrete highway bridges. The statistics is made on the basis of the depot of Saint Petersburg bridges. The latter is characterized by the increased esthetic, and difficult technical operation features. Classification of temporary loads on structures of Saint Petersburg since 1891 was carried out. The stages of occurrence and formation of circulating load norms were analyzed. A certain feature in regulation of requirements for urban bridges was singled out. Examples of the relevant objects were given. A number of conclusions concerning the evolution of design standards were made. Practical importance: Taking into account the specifi city of the large megalopolis, management of technical condition of bridge constructions in Saint Petersburg represents an extremely responsible and difficult task. Authentic, exact and relevant data on the history of design of facilities, circulating load (both design and current) is necessary for the solution of the task in question. Statistical analysis was carried out to apply operation of reinforced concrete bridge constructions in practice as the most mass transportation facilities of the city. From a practical point of view the data in question will make it possible to provide and support the set standard (design) levels of reliability, safety and durability of bridge constructions with a sufficient share of probability.
The study of sandy soils density in the subgrade of road embankment when compacted by explosions of elongated charges
Authors: Gorodnova Elena , Minchenko Anastasiya , Suvorova Ekaterina
Published: May 2019

Objective: To create a solid subgrade for highways and railways fulﬁllment. Methods: Drilling and blasting technology with vertical sand drains formation and explosion energy use was applied. The method in question assumes acceleration of weak organic soils consolidation and loose sands ompaction in the subgrade of the road embankment. Results: Research work was carried out to reduce deformations in the road embankment during the high-speed road construction. Based on the research data, the porosity coefﬁcient and the density index of the sand layer, being the subgrade of the road embankment, were obtained. The article presents a comparison between the results calculated before and after the work. Practical importance: When comparing the results of cone penetration test in soil, obtained at different stages of work, the conclusion was made that the sands in the subgrade of the road embankment were compacted. This fact implies that the application of drilling and blasting technology at sand drains formation results both in weak soils stabilization and also in loose sands compaction. The range of conducted works provides durability and stability in the subgrade of the road embankment.
The development of service conditions for special-purpose cars based on the results of full-scale tests
Authors: Arshintsev Dmitriy , Tolmachev Sergey , Brzhezovskiy Alexander
Published: May 2019

Objective: To develop the conditions of special cargo railway cars, multi-axis container cars and railway non-autonomous multiple unit trains circulation for transportation of special-purpose goods on public railways of OAO “RZhD”. The speeds of such trains can be higher in comparison with the speeds established by the existing normative documents of JSC “Russian Railways” for cargo trains. Special-purpose cars in nominal loading mode circulate in a train set with a unit locomotive. Methods: The assessment of conditions of the special-purpose rolling stock circulation was carried out by the results of tests on the line as well as the impact on the track and pointwork in the accredited centers, based on the regulations of GOST R 55050–2012. Results: The conditions for the ﬂeet circulation consisting of 8–32-axle special-purpose railway cars, multiaxial container cars and non-autonomous multiple unit trains were established. Practical importance: A set of regulatory documents of JSC “Russian Railways” was developed in the form of regulations on technical conditions of special-purpose railway cars, conveyors and multiple unit trains designed for transportation of special purpose freight.
Some special aspects of the use modal-temporal forms in amatory syllabic poetry of Peter the Great’s era
Authors: Semenov Petr A.
Published: May 2019

The research is aimed at revealing the nature of the grammatical norm of the literary language of the transition period and is dedicated to the memory of Nadezhda Gainullina, my favorite teacher and friend. Nadezhda Ivanovna research interests focused on the literary language of the Peter the Great’s era. The development of loanword vocabulary on the material of “letters and papers of Peter the Great” was devoted to her candidate dissertation and doctoral research, articles and monographs containing a deep understanding of the role and place of Peter the Great in the history of the Russian literary language and revealing the deep meaning of the processes taking place during this period in the literary language and, in particular, the state of the language norm. We comprehend this far from us period of the history of the Russian literary language, which has a special theoretical significance, since it is a literary language of the transition period. We have established that such historical periods provide an opportunity to understand the dialectic development of the literary language, the right to raise the question of the relationship between the critical categories of historical styles as a norm, language usage, style. It is approved that findings, which comes to N.I. Gainullina, have important theoretical value. It is concluded that the proposed N.I. Gainullina understanding of the norms of the transition period can be of theoretical importance not only for the Peter the Great's era, but also for any transition period in the history of any literary language, in particular, for understanding the language situation of our time, which is characterized by a sharp change of cultural and historical paradigms, definitely reflected in the modern Russian language, in the language of our days in the form of multilayered innovative layering on the relatively traditional forms of expression.
A few more words about the author’s problem “The Tale of Igor’s Campaign”: why are all the characters of “The Tale”, living at 1185, relatives of Andrei Bogolyubsky?
Authors: Burykin Aleksey A.
Published: May 2019

The study is devoted to the consideration of kinship relations between the princes mentioned in the “The Tale of Igor’s Campaign” and Andrei Bogolyubsky, an attempt to deal with the ambiguity of the identification of princes mentioned in the “The Tale” with those historical figures who are known to us by the names of the chronicles. We reveal the special preferences of “The Tale of Igor’s Campaign” author to the princes consisting in relationship with Andrei Bogolyubsky. It is proved that, despite the fact that the main characters of the story “The Tale of Igor’s Campaign” were Olgovichi, descendants of Oleg Gorislavich – his grandchildren Igor and Vsevolod, his grandchildren Svyatoslav of Kiev and Yaroslav of Chernigov, the majority of heroes “The Tale of Igor’s Campaign” to which Svyatoslav addressed in his “Golden word”, are close and distant relatives of Andrei Yuryevich Bogolyubsky. This statement is true even in cases where the identification of one or another prince is difficult, because the alternative identification of princes fit into the same relationship with Andrei Bogolyubsky, most often it’s great-grand nephews. It is proved that the consideration of genealogical relations between princes mentioned in the “The Tale” is greatly complicated by the lack of information about individual princes and as a consequence – a lot of personal identification of princes.
COMBINED TARGET SITE VGSC MUTATIONS PLAY A PRIMARY ROLE IN PYRETHROID RESISTANT PHENOTYPES OF Aedes aegypti AS DENGUE VECTOR FROM PALU CITY, CENTRAL SULAWESI
Authors: Umniyati Sitti Rahmah
Published: May 2019

It has been reported that Aedes aegypti mosquitoes in Palu City had been resistant to cypermethrin insecticide but the resistance mechanism is not well known. This study aimed to determine the resistance status of Ae. aegypti to cypermethrin and whether the mutation of voltage-gated sodium channel (VGSC) was associated with pyretroid resistance in high and low dengue endemic areas in Palu City. Aedes aegypti collected from each village was reared to adult and assayed for susceptibility test to cypermethrin using the CDC bottle bioassay method. PCR primers of AaSCF1 and AaSCR4 were used for screening of IIS6 VGSC gene mutation. PCR primers of AaSCF7 and AaSCR7 were used for screening of IIIS6 VGSC gene mutation. For an identification of mutation sites were sequenced and aligned to Gene bank (access No. AB914689 and AB914690) for IIS6 VGSC and Gene bank (access No. AB914687 and AB914688) for IIIS6 VGSC gene mutation. The susceptibility status of Ae. aegypti to cypermethrin was resistant in high dengue endemic areas and moderately resistant in low dengue endemic areas. It was found double point mutation at S989P and V1016G in Ae. aegypti from high and low dengue endemic areas in Palu City and there was a single point mutation only in high dengue endemic area at target site V1016G. Aedes aegypti from both high and low dengue endemic areas were resistant to cyperpethrinn and the two alleles had a major role in the occurrence of cypermethrin resistance in Palu City.
OVERVIEW OF NUCLEAR FACTOR-KB (NF-KB) AND NON-STRUCTURAL PROTEIN 1 (NS1) IN PATIENTS WITH DENGUE FEVER IN PREMIER HOSPITAL, SURABAYA
Authors: Budiutari Ni Nyoman , Dachlan Yoes Prijatna , Nugraha Jusak
Published: May 2019

Dengue fever (DF) is an acute viral fever caused by RNA virus that is transmitted by Aedes aegypti and Aedes albopictus mosquitoes. DF is also called viral arthropod-borne disease and is accompanied by headaches, joint and muscle pain. The main target of dengue infection is macrophages or monocytes and dendritic cells (DC). Infected DC is caused the viral replication and the endocytosis into endosomal, easier, thus inducing the activation of NF-ĸB transcription factor to produce proinflammatory cytokines such as Tumor Necrosis Factor-α (TNF-α), Interleukin-1 (IL-1), IL-6, IL-12 and chemokine. NF-kB is one of the transcription factors involved in the regulation of the expression of various cytokines, chemokines and anti/pro-apoptotic proteins during infection and act as indicator of disease severity. Infected DC cells are secreted NS1 protein which is the co-factor needed for viral replication and can be detected in the first eight days. The level will be higher in the initial phase of fever. The purpose of this study was to analyze the description of NF-kB and NS1 levels in the serum of patients with dengue fever through observational analytic studies through a cross-sectional approach. This study was done on 40 patients with dengue fever and 10 healthies people as negative controls. NS1 was analyzed in serum of Panbio rapid test and NF-kB level were measured by sandwich ELISA. The results are showed positive and negative NS1 results in dengue fever patients. The average NF-kB serum level in dengue fever patients was found to be higher than the control. NF-ĸB level in negative NS1 was higher than the NS1 positive group. It is showed that NS1 is detected both in the acute phase. The detection of NF-ĸB is showed the involvement of transcription factors in the development of dengue virus infection and has a protective role for host cells.
The Value of Diffusion-weighted Magnetic Resonance Imaging in the Preoperative Evaluation of the Grade of Brain Gliomas
Authors: Byvaltsev V. A. , Stepanov I. A. , Kichigin A. I.
Published: May 2019

Objective. To compare the values obtained for the measured diffusion coefficient (MDC) of brain gliomas with cell density and Ki-67 proliferative activity index and to study whether diffusion-weighted MRI (DWMRI) can be used in the preoperative evaluation of the grade of glial tumors.

Material and methods. Diffusion-weighted images of 39 patients with brain gliomas were studied. MDC, cell density, and Ki-67 proliferative activity index were calculated for each tumor. The correlation between MDC values, cell density, and Ki-67 proliferative activity index was analyzed.

Results. Comparison of the mean values for MDC revealed a significant difference between grades I–II and III–IV tumors. There were statistically significant differences in the mean Ki-67 index between different grades of gliomas. Evaluation of the correlation between MCD and Ki-67 proliferative activity index demonstrated moderate and strong inverse correlations for low- and high-grade tumors, respectively.

Conclusion. The procedure using DW-MRI along with MDC calculation can be used as an additional noninvasive method for the preoperative estimation of the grade and proliferative potential of brain gliomas.