bluuebunny/crossref_metadata_2025 huggingface dataset:
The sensitivity of acute myeloid leukemia cells to cytarabine is increased by suppressing the expression of Heme oxygenase-1 and Hypoxia-inducible factor 1-alpha
Authors: Sadeghi Mohammad , Moslehi Asma , Kheiry Hadiseh , Kiani Fariba Karoon , Khodakarami Atefeh , Karpisheh Vahid , Masjedi Ali , Rahnama Badrossadat , Hojjat-Farsangi Mohammad , Raeisi Mortaza , Yousefi Mehdi , Akbari Ali Akbar Movasaghpour , Jadidi-Niaragh Farhad
Published: January 2024

Background
Acute myeloid leukemia (AML), a malignancy Often resistant to common chemotherapy regimens (Cytarabine (Ara-c) + Daunorubicin (DNR)), is accompanied by frequent relapses. Many factors are involved in causing chemoresistance. Heme Oxygenase-1 (HO-1) and Hypoxia-Inducible Factor 1-alpha (HIF-1α) are two of the most well-known genes, reported to be overexpressed in AML and promote resistance against chemotherapy according to several studies. A main chemotherapy agent used for AML treatment is Ara-c. We hypothesized that simultaneous targeting of HO-1 and HIF-1α could sensitize AML cells to Ara-c.
Method
In this study, we used our recently developed, Trans-Activator of Transcription (TAT) - Chitosan-Carboxymethyl Dextran (CCMD) - Poly Ethylene Glycol (PEG) - Nanoparticles (NPs), to deliver Ara-c along with siRNA molecules against the HO-1 and HIF-1α genes to AML primary cells (ex vivo) and cell lines including THP-1, KG-1, and HL-60 (in vitro). Subsequently, the effect of the single or combinational treatment on the growth, proliferation, apoptosis, and Reactive Oxygen Species (ROS) formation was evaluated.
Results
The designed NPs had a high potential in transfecting cells with siRNAs and drug. The results demonstrated that treatment of cells with Ara-c elevated the generation of ROS in the cells while decreasing the proliferation potential. Following the silencing of HO-1, the rate of apoptosis and ROS generation in response to Ara-c increased significantly. While proliferation and growth inhibition were considerably evident in HIF-1α-siRNA-transfected-AML cells compared to cells treated with free Ara-c. We found that the co-inhibition of genes could further sensitize AML cells to Ara-c treatment.
Conclusions
As far as we are aware, this study is the first to simultaneously inhibit the HO-1 and HIF-1α genes in AML using NPs. It can be concluded that HO-1 causes chemoresistance by protecting cells from ROS damage. Whereas, HIF-1α mostly exerts prolific and direct anti-apoptotic effects. These findings imply that simultaneous inhibition of HO-1 and HIF-1α can overcome Ara-c resistance and help improve the prognosis of AML patients.
Effects of jejunum ATPase activity and antioxidant function on the growth performance, feed conversion efficiency, and intestinal flora of Hu sheep (Ovis aries)
Authors: Chen Zhanyu , Wang Guoxiu , Wang Weimin , Wang Xiaojuan , Huang Yongliang , Jia Jiale , Gao Qihao , Xu Haoyu , He Lijuan , Xu Yunfei , Liu Zhen , Sun Jinlin , Li Chong
Published: January 2024

Background ATPase activity and the antioxidant function of intestinal tissue can reflect intestinal cell metabolic activity and oxidative damage, which might be related to intestinal function. However, the specific influence of intestinal ATPase activity and antioxidant function on growth performance, feed conversion efficiency, and the intestinal microbiota in sheep remains unclear.Results This study analyzed the correlation between ATPase activity and antioxidant function in the jejunum of 92 Hu sheep and their growth performance and feed conversion efficiency. Additionally, individuals with the highest (H group) and lowest (L group) jejunum MDA content and Na+ K+-ATPase activity were further screened, and the effects of jejunum ATPase activity and MDA content on the morphology and microbial community of sheep intestines were analyzed. There was a significant correlation between jejunum ATPase and SOD activity and the initial weight of Hu sheep (P < 0.01). The H-MDA group exhibited significantly higher average daily gain (ADG) from 0 to 80 days old and higher body weight (BW) after 80 days. ATPase and SOD activities, and MDA levels correlated significantly and positively with heart weight. The jejunum crypt depth and circular muscle thickness in the H-ATP group were significantly higher than in the L-ATP group, and the villus length, crypt depth, and longitudinal muscle thickness in the H-MDA group were significantly higher than in the L-MDA group (P < 0.01). High ATPase activity and MDA content significantly reduced the jejunum microbial diversity, as indicated by the Chao1 index and observed species, and affected the relative abundance of specific taxa. Among species, the relative abundance of Olsenella umbonata was significantly higher in the H-MDA group than in the L-MDA group (P < 0.05), while Methanobrevibacter ruminantium abundance was significantly lower than in the L-MDA group (P < 0.05). In vitro culture experiments confirmed that MDA promoted the proliferation of Olsenella umbonata. Thus, ATPase and SOD activities in the jejunum tissues of Hu sheep are predominantly influenced by congenital factors, and lambs with higher birth weights exhibit lower Na+ K+-ATPase, Ca2+ Mg2+-ATPase, and SOD activities.Conclusions The ATPase activity and antioxidant performance of intestinal tissue are closely related to growth performance, heart development, and intestinal tissue morphology. High ATPase activity and MDA content reduced the microbial diversity of intestinal tissue and affect the relative abundance of specific taxa, representing a potential interaction between the host and its intestinal microbiota.
Synthesis, physicochemical, XRD/HSA-interactions, Heteromeric [CH⋅⋅⋅Cl/CH⋅⋅⋅πPh] synthon, DFT, thermal and 1BNA-DNA docking of cis-Ni(S,N) 2 complex using hydrazine carbodithioate Schiff base
Authors: Boshaala Ahmed , Al-Maharik Nawaf , Qrareya Hisham , Abrahem Abrahem F. , Muhmoud Iman , Kaziri Ibtisam , Alghazeerr Rabia , Greesh Nagi , Zarrouk Abdelkader , Shalalin Khalil , Warad Ismael
Published: January 2024

The reaction of bidentate-S,N-thione Schiff base ligand, Phenyl (E)-2-(1-phenylethylidene)hydrazine-1-carbodithioate (PPEHCDT) with NiCl2.3H2O produced a neutral NiII(S,N)2 complex in high yield. The structural formula of the obtained material was established by, EDX, FAB-MS, UV-Vis, IR, CHN and XRD-crystal analysis. The XRD-results revealed a cis-isomer as anionic S-thiol and bis-bidentate-N-azomethine and as well as a slightly distorted square planar neutral cis-Ni(PPEHCDT)2 complex. In contrast, the DFT simulation supported a distorted tetrahedral as favor geometry, despite that the XRD/DFT structural parameters results were in agreement. Moreover, the Molecular Electrostatic Potential (MEP) together with the Hirshfeld Surface Analysis (HSA) confirmed the XRD seen in appearing of the Heteromeric sub-synthons via C-H….πPh and C-H⸱⸱⸱S interactions. Moreover, the thermal properties of the cis-Ni(PPEHCDT)2 complex was determined via TG/DTG. Additionally, molecular docking has been evaluated for both, the free ligand and its cis-Ni(PPEHCDT)2 complex against 1BNA-DNA.
Emergence of exchange bias in van der Waals magnetic alloy CrxPt1-xTe2
Authors: Bailey-Crandell Ryan , Huey Warren , Williams Archibald , Zhou Wenyi , Goldberger Joshua , Kawakami Roland
Published: January 2024

CrxPt1-xTe2 is a recently developed van der Waals magnetic alloy noted for its stability under ambient conditions. Here, we report the emergence of an exchange bias effect in CrxPt1-xTe2, without typical exchange bias sources such as an adjacent antiferromagnetic layer. We find that the exchange bias is present for x = 0.45 and absent for x = 0.35, which is correlated to the presence of a Cr modulation where the Cr concentration alternates each vdW layer (modulation period of 2 layers) for x > 0.4. We perform Monte Carlo simulations utilizing exchange parameters from first-principles calculations, which recreate the exchange bias in hysteresis loops of CrxPt1-xTe2. From our simulations, we infer the source of exchange bias to be magnetic moments locked into free energy minima that resist magnetization reversal. This work presents a way to introduce desirable magnetic properties to van der Waals magnets.
In silico and in vitro study of rice bran peptides for the treatment of oxidative stress diabetes and hypertension
Authors: Amin Md. Ruhul , Mojumder Md Nijamuddin , Alauddin Md , Rahman Md Ratul , Ferdous Nilufa , Faruque Md. Omar , Siddiquee Muhammad Ali , Howlader Zakir Hossain
Published: January 2024

The study explores the health benefits of rice bran protein hydrolysates and bioactive peptides, focusing on their anti-oxidative, anti-diabetic, and anti-hypertensive properties through in-silico and in-vitro analyses. Rice bran proteins were isolated and in vitro enzymatically digested to assess soluble peptide concentration, degree of hydrolysis (DH), anti-oxidative properties, and inhibitory activity against α-amylase and angiotensin-I-converting enzyme (ACE). This study indicates a higher degree of protein hydrolysis (84.0-99.1%) in various rice bran protein fractions, demonstrating increased hydrolysis with both single and multiple enzyme digestion. The alcalase enzyme was notably efficient for the DH of all protein hydrolysates, and the combination of enzymes (alcalase-trypsin) exhibited the highest DH in the prolamin fraction. Moreover, alcalase-trypsin (4h digested) demonstrated significant inhibitory activity against α-amylase and ACE, respectively. Additionally, in-silico studies were implemented to investigate bioactive peptides binding affinity to the target protein compared to reference drugs. Our study discovered that YY and IP peptides exhibit the highest binding affinity to ACE and α-amylase target proteins, respectively. Moreover, these peptides demonstrated favorable oral bioavailability and non-toxic behavior compared to reference drugs in molecular dynamics (MD) simulations. This encourages the development of nutraceuticals and dietary supplements based on rice bran protein hydrolysates, supported by additional in-vivo research.
A multilayer Doyle-Fuller-Newman model to optimise the rate performance of bilayer cathodes in Li ion batteries
Authors: Tredenick E. C. , Wheeler S. , Drummond R. , Sun Y. , Duncan S. R. , Grant P. S.
Published: January 2024

Bilayer cathodes comprising two active materials are explored for their ability to improve lithium-ion battery charging performance. Electrodes are manufactured with various arrangements of lithium nickel manganese cobalt oxide Li[Ni0.6Co0.2Mn0.2]O2 (NMC622) and lithium iron phosphate LiFePO4 (LFP) active particles, including in two different discrete sub-layers. We present experimental data on the sensitivity of the electrode C rate performance to the electrode design. To understand the complex bilayer electrode performance, and to identify an optimal design for fast charging, we develop an extension to the Doyle-Fuller-Newman (DFN) model of electrode dynamics that accommodates different active materials in any number of sub-layers, termed the multilayer DFN (M-DFN) model. The M-DFN model is validated against experimental data and then used to explain the performance differences between the electrode arrangements. We show how the different open circuit potential functions of NMC and LFP can be exploited synergistically through electrode design. Manipulating the Li electrolyte concentration increases achievable capacity. Finally the M-DFN model is used to further optimise the best performing bilayer electrode arrangement by adjusting the ratio of the LFP and NMC sub-layer thickness.
Partial Cooperation, Spatial Agglomeration, and Heterogeneity of Firms in a Horizontal and Vertical Differentiation
Authors: Chen Tai-Liang , Huan Fengning
Published: January 2024

This paper constructs a horizontally and vertically differentiated product model in a repeated, collusive pricing game. Based upon different profit-sharing rules, it examines the interacting effects of (vertical) quality distortion and cost difference on (horizontal) market competition. It shows that the asymmetry between marginal cost and perceived quality matters for the emergence of agglomeration. If the magnitude of cost differentials between firms is equal to the magnitude of quality difference, minimal horizontal differentiation emerges in each period regardless of the order of moves and profit-sharing rules. If the magnitudes of cost and quality differences differ, non-minimal horizontal differentiation emerges in each period in a simultaneous-move game. In a sequential-move game, the second-mover advantage exists if the second mover’s strong suit dominates the first mover’s one. Spatial agglomeration/minimal differentiation emerges when the second mover chooses the same location as the first mover under profit maximization. The heterogeneity creates a conflict of interest between firms. Hence, agglomeration appears with the heterogeneity of firms under certain conditions in equilibrium.
JEL classification: C70, D43, L11, R12
Molecular markers of artemisinin resistance during falciparum malaria elimination in Eastern Myanmar
Authors: Thu Aung Myint , Phyo Aung Pyae , Pateekhum Chanapat , Rae Jade , Landier Jordi , Parker Daniel M , Delmas Gilles , Watthanaworawit Wanitda , McLean Alistair R. D. , Arya Ann , Reyes Ann , Li Xue , Miotto Olivo , Soe Kyaw , Ashley Elizabeth A , Dondorp Arjen , White Nicholas J , Day Nicholas P , Anderson Tim J. C , Imwong Mallika , Nosten Francois , Smithuis Frank M
Published: January 2024

Background
Artemisinin resistance in Plasmodium falciparum threatens global malaria elimination efforts. To contain and then eliminate artemisinin resistance in Eastern Myanmar a network of community-based malaria posts was instituted and targeted mass drug administration (MDA) with dihydroartemisinin-piperaquine (three rounds at monthly intervals) was conducted. The prevalence of artemisinin resistance during the elimination campaign (2013-2019) was characterized.
Methods
Throughout the six-year campaign Plasmodium falciparum positive blood samples from symptomatic patients and from cross-sectional surveys were genotyped for mutations in kelch-13 – a molecular marker of artemisinin resistance.
Result
The program resulted in near elimination of falciparum malaria. Of 5,162 P. falciparum positive blood samples genotyped, 3,281 (63.6%) had K13 mutations. The prevalence of K13 mutations was 73.9% in 2013 and 64.4% in 2019. Overall, there was a small but significant decline in the proportion of K13 mutants (p<0.001). In the MDA villages there was no significant change in the K13 proportions before and after MDA. The distribution of different K13 mutations changed substantially; F446I and P441L mutations increased in both MDA and non-MDA villages, while most other K13 mutations decreased. The proportion of C580Y mutations fell from 9.2% (43/467) before MDA to 2.3% (19/813) after MDA (p<0.001). Similar changes occurred in the 487 villages where MDA was not conducted.
Conclusion
The malaria elimination program in Kayin state, eastern Myanmar, led to a substantial reduction in falciparum malaria. Despite the intense use of artemisinin-based combination therapies, both in treatment and MDA, this did not select for artemisinin resistance.
Chronoamperometric determination of the diffusion coefficient in molten chlorides
Authors: Kim In Ui , Kim Junhyeong , Lee Chang Hwa , Cho Sung Ki
Published: January 2024

In this study, a method based on chronoamperometry (CA) with a simple unshielded microwire electrode and macroelectrode was used to estimate the diffusion coefficient (D) of the electroactive species in molten chlorides without any knowledge of its concentration. Theoretically evaluated CA response ratios of the two electrodes were fitted to the values obtained from digital simulations and experiments within a measurement time of 1 s, and the D value was determined as a fitting parameter. Theoretical and experimental analyses of the CA response under pure diffusion-controlled conditions confirmed the applicability of the proposed method for the determination of D for any electroactive species, regardless of its reaction kinetics characteristics. The D values of Eu3+ and Cr2+ in molten LiCl–KCl at 450 ℃, which were determined from the CA of their reduction reactions and validated by simulations of the microwire-electrode CA response, were consistent with previously reported values. However, the D of Cr2+ could not be accurately determined from the CA of its oxidation, possibly owing to the additional chronoamperometric current generated by the dissolution of the Au electrode. Therefore, the prevention of side reactions is vital for the accurate estimation of D. The proposed method could facilitate future research on molten salts and their properties.
Effect of Gender on Spect Myocardial Perfusion Imaging Results in Egypt
Authors: Ahmed Taghreed Abdel-Rahman , AL-HABBAA Ahmed , Naiem Mona , Mokhtar Naglaa , Elhady Fatma
Published: January 2024

Background
Ischemic heart disease (IHD) is one of the leading causes of morbidity and mortality around the world. Men are more affected than women and the more the population age, the more is the prevalence. There was a concern about improper referral of women to MPI testing. We aim to study if there a gender effect on the results of MPI studies and if this could have an impact on future referral or investigation selection for diagnosis of IHD as a general or specially in women.
Methods
The current study was a retrospective observational study that enrolled 443 consecutive patients who were candidates for myocardial perfusion imaging. The study was conducted throughout the period from January 2021 to October 2023.
Results
Female gender represented 266 (60%) while male represented in 177 (40%). Males demonstrated significantly higher age (55 ± 10 vs. 49 ± 9, P < .0001), weight (85 ± 11 vs. 83 ± 13, P = 0.006), height (166 ± 4 vs. 165 ± 4, P = 0.02), and smoking (35% vs. 0%, P < 0.001) than females. Male gender was associated with ten times increased risk of positive MPI (OR = 10, 95% CI = 5.348–18.868, P < 0.001). Diabetes was associated with an increased risk of positive MPI (OR = 1.82, 95% CI = 1.052–3.148, P = 0.032).
Conclusions
Positive MPI test are more common in males. Female patients with positive MPI were younger in age than male patients. Diabetes mellitus and age are traditional strong predictors for the presence of positive MPI test.
An Integrated Technique for Securing Large Virtual Machine Migration
Authors: Bhattacharjee Shiladitya , Choudhury Tanupriya , Abdelmoniem Ahmed M. , Kotecha Ketan
Published: January 2024

Maintaining data confidentiality and integrity during the large VM migration is quite challenging. Simultaneously, the use of complex encryption or steganography for managing them increases data and time overheads. These may cause data loss. The transportation of large VMs further consumes significant bandwidth and causes page faults. However, these issues aren't dealt with in modern literature, despite many research attempts. Moreover, unlawful intrusions and various transmission errors make these matters worse. Hence, this research work proposes an efficient technique that addresses such outstanding issues in a unified way. The suggested solution has a special data compression method that reduces big VM sizes to 53.9%, a new steganography method to enhance data confidentiality and integrity, and a smart split migration method to stop page faults as well as lower data loss to 0.0009%. The results further show that it cuts down on downtime by 10% more than the existing VM migration methods. The obtained results justify its efficiencies over other existing ones in distinct dimensions.
C-reactive protein to albumin ratio and risk of incident metabolic syndrome in community-dwelling adults: longitudinal findings over a 12-year follow-up period
Authors: Lim Taekyeong , Lee Yong-Jae
Published: January 2024

Aim
The CRP-to-albumin (CRP/Alb) ratio has emerged as a novel biomarker for various inflammatory diseases. This study aimed to evaluate the association between the CRP/Alb ratio and incident metabolic syndrome (MetS) with a large-sample, community-based Korean cohort over a 12-year follow-up period.
Materials and Methods
Among 10,030 participants, a total of 6,205 participants aged 40 to 69 years without MetS were selected from the Korean Genome and Epidemiology Study (KoGES). The baseline CRP/Alb ratio was divided into quartiles. Our definition of newly developed MetS was the one proposed by the 2009 Joint Interim Statement of Circulation. Hazard ratios (HRs) with 95% confidence intervals (CIs) for incident MetS were calculated using multivariate Cox proportional hazards regression models after adjusting for potentially confounding variables.
Results
During the 12-year follow-up period, MetS developed in 2,535 subjects (40.9%, 2,535/6,205) with an incidence rate of 5.6–11.9 (over 2 years). Compared to the reference first quartiles, the HRs (95% CIs) of incident MetS in the second, third, and fourth quartiles increased in a dose-response manner. Compared to the reference quartile, the HRs (95% CIs) for the incidence of MetS for the highest quartiles of CRP/Alb ratio was 1.47 (1.31–1.65) when considering age, sex, smoking status, alcohol intake, physical activity, TG level, HDL-C, mean arterial pressure, and HOMA-IR in the multivariate analysis.
Conclusions
High CAR at baseline may be a useful surrogate indicator of future incident MetS.
Pressure Ulcer and Associated Factors Among Adult Patients Admitted To The Surgical Wards in The Comprehensive Specialized Hospital Of The Northwest Amhara Regional State, Ethiopia
Authors: Bekele Habtamu , Zemene Workie , Tesfaye Mrs.Eleny
Published: January 2024

Introduction: Pressure ulcers are a serious concern in patients with prolonged bedtime and present with common complications following surgery. It is one of the key performance indicators of the quality of nursing care provided to patients. and several studies have reported the prevalence of pressure ulcers in Ethiopia. There is a lack of evidence regarding its prevalence and associated factors in the current study area. The main objective of this study was to assess pressure ulcers and their associated factors among adult patients admitted to the surgical ward of the Amhara Regional Comprehensive Specialized Hospital in Northwest Ethiopia in ,2023.
Method: An institution-based, cross-sectional study was conducted from June 15 to June 19 ,2023 in NorthWest Ethiopia.and a systematic random sampling technique was used to select 480 patients . Descriptive data were presented as absolute numbers with percentages , and multivariate analysis was used to assess the statistical association between a ssociated factors and pressure ulcers . P < 0.05 indicated Statiscal significance .
Results: A total of 49 pressure ulcer cases were detected among 480 patients. a prevalence rate of 10.2%, 95% CI (7.7, 12.9). Participants who had smoked (95% CI: AOR 7.46 (2.64,21.06), were bedridden (95% CI: AOR 3.92 (1.28, 11.66), had length of hospital stay of 21days (95% CI: AOR 3.01 (1.13, 8.02), had pain (95% CI: AOR 3.20 (1.06, 7.51), or had friction and shear (95% CI: AOR 5.71 (1.91, 17.08), were found to be significant factors associated with pressure ulcers .
Conclusion: This study showed that a high percentage of Pus among patients had pressure ulcers. Smoking status, pain, bedridden status , friction and shear problems, and length of hospital stay were significantly associated with pressure ulcers . Healthcare providers should educate patients about smoking risk, pain management, mattress installation, and linen care.
https://www.texilajournal.com/academic-research/article/2441-analysis-of-health
Authors: Chipalo Edson , Obasi Odii Ikenna
Published: January 2024

Digital sexual violence correlates with cyberbullying victimization, leading to the manifestation of psychological distress and diverse forms of suicidality such as thoughts, attempts, and self-harm. The purpose of this study was to examine the prevalence and association between exposure to digital sexual violence and mental health outcomes (i.e., mental distress and suicide risk) for boys and girls aged 13 to 24 in Namibia. This cross-sectional study utilized national data from the 2019 Namibia Violence Against Children and Youth Survey (VACS) involving 5,191 participants, with 4,211 being girls and 980 boys. Chi-square tests were used to determine the prevalence estimates and significant association for bivariate, and two logistic regression models were applied to assess the significant association for multivariate. The prevalence results indicated that exposure to digital sexual violence was associated with higher rates of moderate/severe mental distress in the past 30 days (boys [64.5%] vs. girls [65.2%]) and increased lifetime risk of suicide (boys [27.4%] vs. girls [40.1%]). Similarly, regression results showed that exposure to digital sexual violence was associated with a higher likelihood of reporting moderate/severe mental distress in the past 30 days (boys: 95% CI = 4.67-22.09; girls: 95% CI =2.75-4.88) and a lifetime risk of suicide (boys: 95% CI =2.16-10.63; girls: 95% CI = 2.68-4.75). In order to reduce mental distress and suicide risk behaviors, interventions should include implementing a safer online environment through digital literacy programs, reducing stigma, offering mental health counseling services, and establishing crisis hotlines for victims of digital sexual violence in Namibia. Keywords: Boys, Digital sexual violence, Exposure, Girls, Mental distress, Namibia, Suicide risk.
Factors Affecting Skill Acquisition during Clinical Learning Among Preservice Registered Nursing Students at Levy Mwanawasa Medical University in Lusaka, Zambia
Authors: Tambo Roseline , Kabinga Makukula Marjorie , Nankamba Namayipo
Published: January 2024

Clinical learning is integral to nursing education, essential for the competence development required in a three-year diploma program. This research aimed to investigate factors affecting skill acquisition during clinical learning among preservice Registered Nursing students at Levy Mwanawasa Medical University in Lusaka, Zambia. A cross-sectional descriptive design, employing a self-administered adapted questionnaire pretested for reliability in the UK and Swaziland (Cronbach’s alpha: 0.77–0.96, correlation: 0.74) was used. Stratified random sampling based on training level selected 80 participants meeting inclusion criteria through a random sampling method. Data analysis included descriptive statistics, chi-square tests, and binary logistic regression using SPSS version 26, with a 95% confidence interval and 5% significance level. The study identified four predictors significantly correlated with skill acquisition during clinical learning: inadequate supportive learning environment (100%, n=80, p=0.003), inadequate Student-Patients allocation (83.75%, p=0.048), and inadequate Resources (56.25%, p=0.002), and inadequate motivation to learn (51.25%, p=0.037). Incompetence of clinical instructors and mentors (57.5%, p=0.233) and mild Anxiety (85%, p=0.762). Binary Logistic Regression, adjusted for independent variables, indicated that an improved supportive learning environment decreased skill acquisition odds (Odds Ratio=0.049, p=0.025), while increased resource availability raised odds (Odds Ratio=3.338, p=0.01) for students who perceived these variables as inadequate. The omnibus test was significant (chi-square=14.095, p=0.015), accurately classifying 72.5% of cases. Collaboration among educators, clinical staff, and policymakers is crucial for enhancing nursing education quality by addressing factors affecting clinical skills acquisition. Keywords: Anxiety, clinical learning, competence of clinical instructors and mentors, resources, skill acquisition, supportive learning environment.
https://www.texilajournal.com/academic-research/article/2452-research-output-and
Authors: Phiri Jonas
Published: January 2024

The Church is a non-profit commonweal and service organization. She exists for the promotion of integral human development. She does this through her institutions of education, health, spiritual - pastoral and social welfare. However, most of these Catholic institutions are managed with insufficient strategic planning. As a result, low performance characterizes them. The focus of this paper is enhancing strategic planning for high - performance of Catholic institutions in Zambia. It underscores the need for strategic planning for efficient and effective management of Catholic institutions and identifies deficient proficiency because of inadequate strategic planning. The study was conducted in seven (7) institutions in Lusaka District and some parts of Central Province. The sample size was 257. There were 252 questionnaires which were administered purposively and randomly to first line, middle and top leadership, and management positions, and 5 in-depth interviews were purposively carried out. The research discovered that Catholic institutions were not proficient because they did not have a clear vision, precise policies and procedures, sufficient financial capacity and did not have the ability to adapt to changing times. Recommendations were made thus, to build capacity of leaders and managers in the areas of management audit, leadership and management development, and strategic management. Theoretically, the results can be generalised to all Catholic institutions in Zambia. Keywords: Catholic institutions, management audit, leadership and management development, Strategic planning, strategic management.
AI-Embedded UAV System for Detecting and Pursuing Unwanted UAVs
Authors: KAMANLI Ali Furkan
Published: January 2024

In recent years, the use of unmanned aerial vehicle (UAV) platforms in civil and military applications has surged, highlighting the critical role of artificial intelligence (AI) embedded UAV systems in the future. This study introduces the Autonomous Drone (Vechür-SIHA), a novel AI-embedded UAV system designed for real-time detection and tracking of other UAVs during flight sequences. Leveraging advanced object detection algorithms and an LSTM-based tracking mechanism, our system achieves an impressive 80% accuracy in drone detection, even in challenging conditions like varying backgrounds and adverse weather.

Our system boasts the capability to simultaneously track multiple drones within its field of view, maintaining flight for up to 35 minutes, making it ideal for extended missions that require continuous UAV tracking. Moreover, it can lock onto and track other UAVs in mid-air for durations of 4-10 seconds without losing contact, a feature with significant potential for security applications.

This research marks a substantial contribution to the development of AI-embedded UAV systems, with broad implications across diverse domains such as search and rescue operations, border security, and forest fire prevention. These results provide a solid foundation for future research, fostering the creation of similar systems tailored to different applications, ultimately enhancing the efficiency and safety of UAV operations. The novel approach to real-time UAV detection and tracking presented here holds promise for driving innovations in UAV technology and its diverse applications.
Pharmacophore Modeling for Pleurotin Derivatives Targeting Human Thioredoxin Reductase
Authors: Quintanilha Daniel , Dos Santos Hélio
Published: January 2024

Pleurotin is a natural compound and potent inhibitor of thioredoxin reductase (TrxR) enzyme, which is a target for cancer chemotherapy. The present study proposes a pharmacophore model for TrxR inhibitors based on the in silico analysis of 34 pleurotin analogues. The results led to ligand 33 with a flexible -SR side-chain at p-quinone and a H-bond donor -CH2NH2 at the oxepane ring. The ligand-TrxR binding free energy was -236 kJ mol-1 for 33, better than pleurotin (-166 kJ mol-1 ). The results provide a clear and practical guide to design pleurotin derivatives with anticancer potential that could expand the pharmacological potential of this class of natural products.
William Gibson’s Sprawl Trilogy: Connection between Humans and Artificial Intelligence
Authors:   Amity Institute of English Studies & Research, Amity University NOIDA, Agrawal Shuchi
Published: January 2024

Artificial intelligence as it is envisioned in literature, reflects moral and social standards, sculpts societal hopes and fears, spurs scientific progress, and perhaps even foretells the future. Artificial intelligence (AI) is being developed by humans, including programmers through their code and authors and readers through millennia of discourse, starting with ancient automatons and continuing with contemporary concepts of AI. The question of what we are producing as AI becomes more human—and possibly superhuman—and what literature can teach us about these AI imaginaries are also topics covered in this paper. The researcher seeks to explain the connections between artificial intelligence and literature in this work by highlighting the numerous ways that machine intelligence helps the production and comprehension of narrative. This study will also look at the connection between humans and artificial intelligence in William Gibson’s Sprawl trilogy and how his cyberpunk trilogy allows readers to think about how the lines between humans and technology are blurring and how technology can both liberate and enslave people.
Financial Performance and Labour Involvement of Small-Scale Dairy Farmers: A Case Study at the SAE Pujon Dairy Cooperative
Authors: Febrianto Nanang , Susilawati Trinil , Hartono Budi , Akhiroh Puji , Yekti Aulia Puspita Anugra , Prafitri Rizki , Helmi Muhammad , Masyithoh Dewi , Shamsudin Mad Nasir
Published: January 2024

In Indonesia, small-scale dairy cattle farming dominates, constituting 80% of the industry, with economic pursuits secondary to subsistence needs. Challenges include limited green fodder, declining farmers, low milk quality, diseases, and inadequate infrastructure. Despite these issues, dairy farming persists, particularly in East Java's Malang Regency, a major contributor to national dairy cattle population and milk production. The significance of Pujon Sub-District comes to the forefront, housing the Sinau Andandani Ekonomi (SAE) Pujon Cooperative established in 1975. This cooperative plays a pivotal role in supporting small-scale farmers in Pujon, actively addressing challenges through collaborative efforts. This cooperative facilitates small-scale farmers in Pujon, addressing challenges through collective efforts. In such systems, family labor, including women and children, is integral due to limited availability. The study aims to analyse the income of dairy cattle farmers and their labour allocation as the members of SAE Pujon Cooperative, Pujon District, Regency of Malang. The data of the farm management parameters were collected through a survey at the study area. The results indicate that the average income of the farmers is IDR 4,306,798 per month. Regarding labour allocations, wives work to household affairs and husbands focus more on farming activities. The research concludes that the income of dairy farmers and their labour allocation are related to the farm scale.
Ficha técnica agroclimática: Herramienta de apoyo para la gestión del riesgo agroclimático en cultivos ecuatoriales, como soporte a la acción de las mesas técnicas agroclimáticas en Colombia
Authors: Castaño Marín Ángela María , Correa Moreno Diana Lucia , Gómez Gil Luis Fernando , Peña Quiñones Andrés Javier , Riaño Herrera Néstor Miguel , Bernal Riobo Jaime Humberto , Góez Vinasco Gerardo Antonio
Published: January 2024

Esta cartilla describe la Ficha Técnica Agroclimática (FTA), una herramienta diseñada para la identificación y gestión de riesgos agroclimáticos en cultivos ecuatoriales. La FTA integra bases ecofisiológicas, conocimiento local y científico para analizar el efecto de eventos climáticos sobre los sistemas de producción agropecuaria. Aplicada de una manera correcta, la FTA permite identificar anticipadamente los riesgos y las oportunidades asociados a la oferta del clima y complementa otras herramientas generadas por Agrosavia. La facilidad en su uso la convierte en un instrumento clave en la planificación rural a diferente escala geográfica. La FTA contribuye a reducir la incertidumbre de las decisiones que se toman en el ejercicio de gestión de sistemas productivos.
Антропологический анализ костных останков из курганного могильника Зунда-Толга-6
Authors:   Kalmyk Scientific Center of the RAS (8, Ilishkin St., 358000 Elista, Russian Federation), Lidzhikova Tatyana V.
Published: January 2024

Introduction. This work is devoted to the anthropological analysis of bone remains using craniological and osteometric techniques. The object of the study is anthropological material from the burial mound of Zunda-Tolga-6 3/2. The purpose of the research is to study the bone remains of the buried from the burial mound of Zunda-Tolga-6 3/2 using anthropological analysis. Materials and methods. The material for the study was bone remains from the burial ground of Zunda-Tolga-6 3/2, stored in the funds of the Kalmyk Scientific Center of the RAS. Classical anthropological techniques were used in the study. Results and conclusions. Anthropological analysis revealed that the buried man had limited physical capabilities of the body and was not particularly active. The inventory found in the burial indicates that the individual belongs to the military class, but anthropological analysis, due to the identified features, indicates the uncharacteristic nature of this skeleton as a skeleton of a warrior.
Kualitas Air Dan Hidrogeokimia Mata Air Di Lereng Selatan Gunungapi Merbabu
Authors: Diwijaya Sonna , Cahyadi Ahmad , Pramono Hadi Mohammad
Published: January 2024

Mata air di lereng selatan Gunungapi Merbabu memiliki peranan yang besar dalam penyediaan air bersih bagi masyarakat di Kecamatan Selo, Kabupaten Boyolali. Penelitian ini bertujuan untuk; (1) menganalisis kualitas air pada mata air di lereng Selatan Gunungapi Merbabu, dan (2) menganalisis karakteristik hidrogeokimia air pada mata air di lereng selatan Gunungapi Merbabu. Penelitian ini dilakukan di Lereng Selatan Gunung Merbabu dengan mengambil 4 sampel mata air, 2 sampel air hujan, dan satu sampel air sungai. Penentuan titik pengambilan sampel mata air berdasarkan sensus berdasarkan data dari Balai Taman Nasional Gunung Merbabu, wawancara penduduk lokal, dan penelitian terdahulu. Analisis kualitas air dilakukan dengan metode matching terhadap  baku mutu air minum Peraturan Pemerintah No. 22 Tahun 2021, Todd dan Mays (2005), dan Guidline for Drinking Water World Health Organization 2022. Analisis hidrogeokimia dilakukan dengan analisis ion mayor dominan menggunakan Schoeller Diagram, analisis tipe kimia dan proses hidrogeokimia yang dominan dengan diagram piper, serta analisis perbandingan ion untuk menentukan proses-proses yang mempengaruhi kondisi hidrogeokimia mata air termasuk sumber pencemaran. Hasil analisis menunjukkan bahwa kualitas air di lokasi kajian dalam kondisi baik. Meskipun semua parameter tidak ada yang melebihi baku mutu, tetapi indikasi terjadinya pencemaran telah terindentifikasi. Selain itu, karakteristik hidrogeokimia dari parameter DHL, TDS dan suhu, serta tipe kimia HCO3- - Ca2+- Mg2+  menunjukkan bahwa mata air disuplai dari air tanah pada akuifer dangkal dan lokal dengan proses utama pengayaan mineral pada zona lengas tanah.
Relationship between acoustic wave velocity and mechanical properties in Acacia mangium wood
Authors: Van Duong Doan , Hasegawa Masumi
Published: January 2024

There is a strong interest in developing and using acoustic technology to evaluate the mechanical properties of wood in situations where a static bending test is not feasible to undertake. In this study, the mechanical properties of Acacia mangium (black wattle) wood were predicted by using stress wave and ultrasonic wave methods. The values of dynamic modulus of elasticity based on stress wave and ultrasonic wave were 9,29 % and 4,75 % higher than those obtained from static modulus of elasticity, respectively. There was no statistically significant correlation between acoustic velocity and mechanical properties measured by destructive tests. The strong experimental correlation coefficients were found between stress wave and modulus of elasticity (r = 0,94; P < 0,001), and ultrasonic wave and modulus of elasticity (r = 0,83; P < 0,001). This result indicates that stress wave and ultrasonic wave techniques are suitable for predicting the static modulus of elasticity of Acacia mangium (black wattle) wood if the density of the measured elements is known. There was no dependence of wood density and acoustic propagation velocity measured in this study, whereas statistically significant correlations were found between the fiber length with stress wave velocity (r = 0,44; P < 0,05) and ultrasonic velocity (r = 0,48; P < 0,05).
ENSINO DE GEOMETRIA MOLECULAR UTILIZANDO SOFTWARE: UMA PROPOSTA DE UNIDADE DE ENSINO POTENCIALMENTE SIGNIFICATIVA
Authors: Oliveira Aline Alves , Guimarães Amanda Ribeiro , Vianna Carlos Alberto Fonseca Jardim
Published: January 2024

O ensino de geometria molecular apresenta grandes desafios, uma vez que ele pode estar condicionado, por exemplo, à simples memorização de nomes e estruturas. Para que haja uma aprendizagem significativa desse conteúdo, a utilização de Tecnologias Digitais de Informação e Comunicação (TDIC) representa um caminho promissor para que o aluno esteja realmente engajado na aprendizagem. Nesse contexto, com o objetivo de subsidiar o professor de Química, propõe-se uma Unidade de Ensino Potencialmente Significativa (UEPS), apoiada no uso do software Avogadro® para o ensino de geometria molecular nas aulas de Química, no Ensino Médio. A UEPS proposta conta com a Atividade 01, na qual se realiza uma discussão sobre ligações covalentes, comprimento e ângulos de ligação e disposição de moléculas no espaço tridimensional. Já na Atividade 02, serão investigadas as geometrias que caracterizam sete moléculas: H2O, NH3, HCℓ, CH4, BF3, PCℓ5 e SF6. Na proposição das atividades, estão incluídas questões norteadoras para que o professor seja capaz de identificar conhecimentos prévios dos alunos e os auxiliem no processo de ampliação dos conhecimentos adquiridos. Ao final da UEPS, são propostas questões para uma percepção da aprendizagem significativa. O material conta, ainda, com um tutorial para uso do software Avogadro® e uma planilha de coleta de dados das simulações. Espera-se que a proposta da UEPS auxilie os docentes na elaboração e na condução das aulas sobre o tema geometria molecular, promovendo a aprendizagem significativa dos discentes.
Alleviating Energy Poverty in Europe: Front-runners and Laggards
Authors: Rodriguez-Alvarez Ana , Llorca Manuel , Jamasb Tooraj
Published: January 2024

Despite the recognition of affordability as one of the pillars of the sustainable energy transition, according to recent reports from the European Commission, approximately 34 million Europeans were considered as energy poor. In the current spiralling prices of gas and electricity coupled with the impact of COVID-19 on economic activity, unemployment, and households’ disposable income, this social policy issue is likely to gain more prominence in the near future. In this new paper, we propose a new approach to the analysis of energy poverty. Our results show that countries with higher economic development and more egalitarian economies have a lower incidence of energy poverty, while higher energy prices exacerbate the problem. Moreover, social protection aids to households and individuals (in the form of benefits to those affected by issues such as disability, sickness/healthcare or social exclusion) have had a significant effect on reducing energy poverty.
Diagnostic Value of Monocyte, Eosinophil, Platelet-Lymphocyte Ratio And Monocyte Lymphocyte Ratio In Previously Healthy Covid-19 Patients
Authors: Koc Ibrahim , Babalik Mesiha , Yildiz Ozlem , Isıgıbol Rahime Ozgur , Ozmen Sevda Unalli , Zeytinoglu Duygu , Savas Nazan Nalci , Yapici Ilhami , Celikten Halil , Demirsoy Sedat , Deniz Olgun
Published: January 2024

Aim: In this study we aimed to investigate diagnostic usefullness and
optimal cut-off values of monocyte, mean platelet volume (MPV),
eosinophil, neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio
(PLR), monocyte lymphocye ratio (MLR), red blood cell distribution width
(RDW) in laboratory confirmed Covid-19 cases with and without pneumonia
who were totally healthy before being infected with Covid-19. Materials
and Methods: Data of a total 10000 patients who were admitted to
hospital with complaints apropriate with Covid-19 in six months
(March–Agust 2020) interval and underwent SARS-CoV-2 Polymerase Chain
Reaction (PCR) investigated. Out of 10000 patients we included only
previosly healthy 174 patients with Covid-19 pneumonia, 144 SARS-CoV-2
positive but no pneumonia and SARS-CoV-2 PCR negative 156 healthy
controls. The laboratory results and demographic findings were collected
from patient files retrospectively before undergiong treatment for
Covid-19. Results: We found wbc levels lower in Covid-19 patients with
pneumonia (p <0.001 vs healthy), as well as neutrophil (p
<0.001 vs healthy), Monocyte (p <0.001 vs healthy
and Covid-19 without pneumonia), Eosinophil (p <0.001 vs
healthy and Covid-19 without pneumonia) and Platelet count (p
<0.001 vs healthy). MLR remained higher in patients without
pneumonia (p <0.001 vs Covid-19 with pneumonia and healthy
controls) as well as PLR (p <0.001 versus Healthy).
Conclusion: In the light of the obtained results, decrease in wbc,
neutrophil, monocyte and eosinophil levels support the diagnosis of
Covid-19 pneumonia on the other hand increase in MLR and PLR may
indicate Covid-19 without pneumonia. Keywords: Covid-19 pneumonia,
esoinophil, monocyte
Approximation of function by α-Baskakov Durrmeyer type operators
Authors: Kaur Jaspreet , Goyal Meenu
Published: January 2024

In the present note, we give the generalization of α-Baskakov Durrmeyer
operators depending on a real parameter ρ>0. We present the
approximation results in Korovkin and weighted Korovkin spaces. We also
prove the order of approximation, rate of approximation for these
operators. In the end, we verify our results with the help of numerical
examples by using Mathematica.
Interval-valued Trapezoidal Neutrosophic and Multi-Choice Parameters for Multi-objective Production Planning Problem
Authors: Haq Ahteshamul , Khan Mohd , Ahmed Aquil
Published: January 2024

An intuitionistic multi-objective programming problem with
interval-valued trapezoidal neutrosophic (IVTN) and multi-choice
interval type has been considered in this paper. The coefficients of
objective functions and parameters of the left side of the constraints
are in the multi-choice environment, and the right-hand side of the
constraints are in IVTN number type. The formulated problem’s
multi-choice parameters were transformed into the deterministic form
using the binary variable transformation technique. A procedure is
defined to change the IVTN number into the deterministic form. Then,
intuitionistic fuzzy programming with two different scalarization models
has been used to achieve each membership goal’s highest degree and
obtain a satisfactory decision-making solution. Finally, a numerical
case study for production planning is explored to validate the work’s
efficiency and usefulness.