bluuebunny/crossref_metadata_2025 huggingface dataset:
Method development for evaluating the effectiveness of hydrocarbons on BOD, UBOD and COD removal in oily wastewater
Authors: Almutairi Meshari
Published: July 2020

The effects of different operating parameters on the treatment efficiency of oily wastewater in terms of biological oxygen demand (BOD) and chemical oxygen demand (COD) were measured. The analyses of BOD using OxiTop biosensors are reviewed regarding performance characteristics like linearity, response time, precision, agreement between BOD28 values obtained from the biosensors and the ultimate BOD (UBOD), as well as toxic resistance and COD. The wastewater samples were seeded with the bacteria, which were isolated in the current study from Kuwaiti oil-contaminated sand, such as Bacillus mycoidesis and Bacillus subtilis. After 18 days, the margin for saponin solution and oily wastewater using either Rhododcoccus (R), a mixture of Bacillus mycoidesis and Bacillus subtilis (M) or a mixture of R&M exhibited the maximum rate of BOD. It was found that the corresponding COD of the saponin solution (SS) ranged from 1,525 mg/l to 3,890 mg/l by distilled water and the mixture (RM), respectively. The COD of oily wastewater (WW) ranged from 2,900 mg/l to 4,450 mg/l by distilled water and the mixture of (RM), respectively. Moreover, the higher values of BOD28 were recorded when mixtures of bacteria were added together with the saponin solution or oily wastewaters. Furthermore, the average values of UBOD for the oily wastewater with RM or with amendment substance were increased by about 33.5% and 49.5%, respectively. However, BOD28/COD ratios for all the selected have been found to be less than 0.4, indicating low aerobic degradability.
Recent Research on Flavonoids and their Biomedical Applications
Authors: Wen Kangmei , Fang Xiaochuan , Yang Junli , Yao Yongfang , Nandakumar Kutty Selva , Salem Mohamed Labib , Cheng Kui
Published: July 2020

Flavonoids, commonly found in various plants, are a class of polyphenolic compounds
having a basic structural unit of 2-phenylchromone. Flavonoid compounds have attracted
much attention due to their wide biological applications. In order to facilitate further
research on the biomedical application of flavonoids, we surveyed the literature published on
the use of flavonoids in medicine during the past decade, documented the commonly found
structures in natural flavonoids, and summarized their pharmacological activities as well as
associated mechanisms of action against a variety of health disorders including chronic inflammation,
cancer, cardiovascular complications and hypoglycemia. In this mini-review, we
provide suggestions for further research on the biomedical applications of flavonoids.
The Anticancer Potential of Apigenin Via Immunoregulation
Authors: Xu Lu , Zaky Mohamed Y. , Yousuf Waleed , Ullah Anwar , Abdelbaset Gehad R. , Zhang Yingqiu , Ahmed Osama M. , Liu Shuyan , Liu Han
Published: July 2020

Apigenin is an edible flavonoid widely distributed in natural plants, including most vegetables and
fruits. Previous studies have revealed that apigenin possesses multiple biological functions by demonstrating antiinflammatory,
anti-oxidative, anti-bacterial, anti-viral, anti-tumor and cardiovascular protective effects. Furthermore,
recent progressions have disclosed a novel perspective of the anti-cancer roles of apigenin through its immunoregulatory
functions. With the rapid progression of the groundbreaking strategies being developed for cancer
immunotherapy, its immunoregulatory roles are being recognized as intriguing features of the multifaceted
apigenin. However, the current understanding of this emerging role of apigenin still remains limited. Therefore, in
the present review, recent advances on the immunoregulatory properties of apigenin in various diseases with a
special focus on neoplasm, are summarized. Clinical strategies of cancer immunotherapy are briefly introduced
and findings on apigenin linked to immunoregulatory roles in immunotherapy-associated aspects are brought
together. The bioactivity, bioavailability, toxicity and potential of apigenin, to be considered as a therapeutic
agent in anti-tumor immunotherapy, is discussed. Disclosed molecular mechanisms underlying the immunoregulatory
roles of apigenin in cancer immunotherapy are also summarized. Based on findings from the literature,
apigenin has the potential to serve as a prospective adjuvant for anti-cancer immunotherapy and warrants further
investigations.
Discovery of Biomarkers in Hepatocellular Carcinoma Metastasis Using Bioinformatic Analysis
Authors: Wei Jinrui , Ur Rashid Haroon , Wu Lichuan
Published: July 2020

Background:

Liver cancer is one of the most deadly malignancies worldwide. Tumor
metastasis is the main cause of liver cancer-related death. So far, the mechanism of liver cancer
metastasis is far away from fully elucidated. In this study, we aimed to discover key regulators
involved in liver cancer metastasis by data mining.

Methods:

Two different types of data, including mRNA microarray (GSE6222 and GSE6764) and
miRNA microarray (GSE67138), were analyzed. A total of 83 intersectant differently expressed
genes (DEGs) with the same expression pattern in GSE6222 and GSE6764 were identified. One
hundred and thirty-one differently expressed miRNAs (DEMs) were identified in GSE 67138.
Furthermore, a total of 26 pairs of miRNA-target, including 18 DEMs and 13 DEGs were identified
as critical miRNA-target axis via miRNA-target gene interaction analysis.

Result and Conclusion:

Among the 18 DEMs and 13 DEGs, 10 miRNAs and 10 target
genes are significantly correlated with patients’ survival (p<0.05). Our results and methods might be
interesting for data mining and helpful for further experimental functional validation.
Poly (Adenine) Modified Graphene-Based Voltammetric Sensor for the Electrochemical Determination of Catechol, Hydroquinone and Resorcinol
Authors: Manjunatha Jamballi G.
Published: July 2020

Objective:

This paper presents the application of Poly (Adenine) Modified Graphene Paste Electrode (PAMGPE) for the analysis of Catechol (CC) with Resorcinol (RC) and Hydroquinone (HQ) by a voltammetric technique.

Methods:

Electropolymerization technique was utilized for the modification of the sensor surface. The electrode surface was characterized by Field Emission Scanning Electron Microscopy (FE-SEM). Cyclic Voltammetry (CV) and Differential Pulse Voltammetry (DPV) were used to study the redox behavior of CC, RC and HQ.

Results:

Oxidation peak current of CC increased linearly with the concentration of CC in the range from 2×10-6- 8×10-6 M and 1×10-5-1.5 ×10-4 M with a detection limit of 2.4×10-7 M. The practical application of the developed sensor was verified as exact for the determination of CC in water sample.

Conclusion:

The stability, repeatability, and reproducibility of the developed electrode were studied and established good characteristics. Furthermore, the PAMGPE was examined for the simultaneous determination of CC, RC and HQ.
Mandelic Acid: An Efficient Organo-catalyst for the Synthesis of 3-substituted-3- Hydroxy-indolin-2-ones and Related Derivatives in Aqueous Ethanol at Room Temperature
Authors: Kaur Gurpreet , Kumar Rajat , Saroch Shivam , Gupta Vivek Kumar , Banerjee Bubun
Published: July 2020

Background:

Indoles and various indolyl derivatives are very common in naturally occurring
biologically active compounds. Many methods are being developed for the synthesis of various
bioactive indole derivatives.

Objective:

Synthesis of biologically promising structurally diverse indole derivatives under mild and
environmentally benign conditions.

Methods:

Synthesis of 3-hydroxy-3-(5-(trifluoromethoxy)-1H-indol-3-yl)indolin-2-one was achieved
by the reaction of an equimolar mixture of isatin and 3-(trifluoromethoxy)-1H-indol using 20 mol% of
mandelic acid as catalyst in aqueous ethanol at room temperature. Under the same optimized reaction
conditions, synthesis of 3-(3-hydroxy-2-oxoindolin-3-yl)chroman-2,4-diones was accomplished via the
reactions of substituted isatins and 4-hydroxycoumarin. On the other hand, 2-hydroxy-2-(indol-3-yl)-
indene-1,3-diones and 10-hydroxy-10-(5-methoxy-1H-indol-3- yl)phenanthren-9(10H)-one were synthesized
from the reactions of indoles and ninhydrin or 9,10-phenanthrenequinone respectively using
the same 20 mol% of mandelic acid as an efficient organo-catalyst in aqueous ethanol at room temperature.

Results:

Mild, safe and clean reaction profiles, energy efficiency, high atom-economy, use of naturally
occurring non-toxic organo-catalyst, easy isolation procedure by avoiding column chromatographic
purification and gram scale production are some the major advantages of this developed protocol.

Conclusion:

A simple, straightforward and eco-friendly protocol has been developed for the efficient
synthesis of biologically promising novel 3-hydroxy-3-(5-(trifluoromethoxy)-1H-indol- 3-yl)indolin-2-
one, 3-(3-hydroxy-2-oxoindolin-3-yl)chroman-2,4-diones, 2-hydroxy-2-(indol-3- yl)-indene-1,3-diones
and 10-hydroxy-10-(5-methoxy-1H-indol-3-yl)phenanthren-9(10H)-one using a catalytic amount of
mandelic acid in aqueous ethanol at room temperature.
Preschool Physical Environment Design Quality: Addressing Malaysia's PISA Rankings
Authors: Shaari Mariam Felani , Sh. Ahmad Sabarinah , Ismail Izaham Shah , Zaiki Yazid
Published: July 2020

PISA assessments revealed cognitive abilities of Malaysian children remained unsatisfactory. Poor cognitive school readiness (SR) among preschoolers, contributing to inadequate cognitive development, is a factor. Excellent preschool physical environments (PPE) could potentially improve childhood cognitive development by boosting cognitive SR. This study aims to highlight the significance of PPE design quality on children's cognitive SR in Malaysia. A cohort study comprising 16 Ministry of Education (MOE) preschools with 336 children was done. PPE design quality showed significant positive association with cognitive SR. Conclusively, good PPE design should contribute to improved PISA ranking by ensuring better cognitive development of Malaysian preschoolers.
A Federated Online Search Tool for Biospecimens (Sample Locator): Usability Study
Authors: Schüttler Christina , Huth Verena , von Jagwitz-Biegnitz Magdaléna , Lablans Martin , Prokosch Hans-Ulrich , Griebel Lena
Published: July 2020

Background

The German Biobank Alliance (GBA) aims to establish a cross-site biobank network. For this endeavor, the so-called Sample Locator, a federated search tool for biospecimens and related data, has been developed, forming the heart of its information technology (IT) infrastructure.

Objective

To ensure the sustainable use of such a tool, we included researchers as participants in an end user–based usability evaluation.

Methods

To develop a prototype ready for evaluation, we needed input from GBA IT experts. Thus, we conducted a 2-day workshop with 8 GBA IT team members. The focus was on the respective steps of a user-centered design process. With the acquired knowledge, the participants designed low-fidelity mock-ups. The main ideas of these mock-ups were discussed, extracted, and summarized into a comprehensive prototype using Microsoft PowerPoint. Furthermore, we created a questionnaire concerning the usability of the prototype, including the System Usability Scale (SUS), questions on negative and positive aspects, and typical tasks to be fulfilled with the tool. Subsequently, the prototype was pretested on the basis of this questionnaire with researchers who have a biobank background. Based on this preliminary work, the usability analysis was ultimately carried out with researchers and the results were evaluated.

Results

Altogether, 27 researchers familiar with sample requests evaluated the prototype. The analysis of the feedback certified a good usability, given that the Sample Locator prototype was seen as intuitive and user-friendly by 74% (20/27) of the participants. The total SUS score by the 25 persons that completed the questionnaire was 80.4, indicating good system usability. Still, the evaluation provided useful advice on optimization potential (eg, offering a help function).

Conclusions

The findings of this usability analysis indicate that the considerations regarding a user-friendly application that have been made in the development process so far strongly coincide with the perception of the study participants. Nevertheless, it was important to engage prospective end users to ensure that the previous development is going in the desired direction and that the Sample Locator will be used in the future. The user comments and suggestions for improvement will be considered in upcoming iterations for refinement.
Optimizing Antibiotic Prescribing for Acute Respiratory Tract Infection in German Primary Care: Study Protocol for Evaluation of the RESIST Program
Authors: Löffler Christin , Krüger Antje , Daubmann Anne , Iwen Julia , Biedermann Marc , Schulz Maike , Wegscheider Karl , Altiner Attila , Feldmeier Gregor , Wollny Anja
Published: July 2020

Background

The emergence and increased spread of microbial resistance is a major challenge to all health care systems worldwide. In primary care, acute respiratory tract infection (ARTI) is the health condition most strongly related to antibiotic overuse.

Objective

The RESIST program aims at optimizing antibiotic prescribing for ARTI in German primary care. By completing a problem-orientated online training course, physicians are motivated and empowered to utilize patient-centered doctor-patient communication strategies, including shared decision making, in the treatment of patients with ARTI.

Methods

RESIST will be evaluated in the form of a nonrandomized controlled trial. Approximately 3000 physicians of 8 (out of 16) German federal states can participate in the program. Patient and physician data are retrieved from routine health care data. Physicians not participating in the program serve as controls, either among the 8 participating regional Associations of Statutory Health Insurance Physicians (control group 1) or among the remaining associations not participating in RESIST (control group 2). Antibiotic prescription rates before the intervention (T0: 2016, 1st and 2nd quarters of 2017) and after the intervention (T1: 3rd quarter of 2017 until 1st quarter of 2019) will be compared. The primary outcome measure is the overall antibiotic prescription rate for all patients insured with German statutory health insurance before and after provision of the online course. The secondary outcome is the antibiotic prescription rate for coded ARTI before and after the intervention.

Results

RESIST is publicly funded by the Innovations funds of the Federal Joint Committee in Germany and was approved in December 2016. Recruitment of physicians is now completed, and a total of 2460 physicians participated in the intervention. Data analysis started in February 2020.

Conclusions

With approximately 3000 physicians participating in the program, RESIST is among the largest real-world interventions aiming at reducing inadequate antibiotic prescribing for ARTI in primary care. Long-term follow up of up to 21 months will allow for investigating the sustainability of the intervention.

Trial Registration

ISRCTN Registry ISRCTN13934505; http://www.isrctn.com/ISRCTN13934505

International Registered Report Identifier (IRRID)

RR1-10.2196/18648
Reactions to an Online Demonstration of the Effect of Increased Fruit and Vegetable Consumption on Appearance: Survey Study (Preprint)
Authors: Cairns Patrick , Ozakinci Gozde , Perrett David Ian
Published: July 2020

BACKGROUND

Inadequate fruit and vegetable consumption causes a considerable disease burden and premature mortality. Despite public health promotion of a healthy diet, the average consumption is still below recommended levels. Fruit and vegetable consumption influences human skin color, increasing red/yellow/orange pigment in the skin. Given that this color is deemed attractive and healthy-looking, the appearance benefit may motivate to eat more fruit and vegetables. Such appearance motivation could be particularly useful in young individuals who currently eat the least fruit and vegetables.

OBJECTIVE

Our objectives were to assess how widely the impact of diet on skin color is known within the UK and to compare the strength of motivation to eat fruit and vegetables based on health and appearance benefits among different demographic groups.

METHODS

Four groups of UK residents (N=200 per group) were recruited through the Prolific online platform. Groups comprised younger (aged 18-24) and older adults (aged 40-60) of low and high self-reported socioeconomic status (1-5 and 6-10 on a 10-point rating scale). Facial images simulating the skin color associated with low and high fruit and vegetable diets were shown to participants. Questionnaires were used to assess (1) background knowledge of the health and skin color effects of dietary fruit and vegetables, (2) the specific motivational impact of the skin color illustration, and (3) the relative importance of motivation to consume fruit and vegetables arising from health and skin color appearance benefits.

RESULTS

We found that 61% (n=487) of all participants were unaware of the dietary–skin color association. We also found that 57% (n=457) of participants found the simple demonstration of the dietary impact on skin color positively motivating to eat more fruit and vegetables. The visual demonstration was equally motivating for participants of high and low self-reported socioeconomic status (P=.63) and different ethnic backgrounds (White N=453, Black N=182, Asian N=87, P=.22). Health benefits from a diet high in fruit and vegetables were regarded as more motivating than skin color appearance benefits. The appearance-changing benefits of a high fruit and vegetable diet (compared to the health benefits) were relatively more important for the younger participants (Mann-Whitney U=96,263, P<.001) and for women (N=489) than for men (N=310, U=83,763, P=.01).

CONCLUSIONS

These findings indicate that the promotion of the skin color effects of diets high in fruit and vegetables could provide additional motivation for a healthier diet. Our study indicates the broad appeal of appearance benefits from dietary fruit and vegetable (across ethnicity and socioeconomic status) and particularly amongst young adults where an inadequate diet is most prevalent.
Including the Reason for Use on Prescriptions Sent to Pharmacists: Scoping Review (Preprint)
Authors: Mercer Kathryn , Carter Caitlin , Burns Catherine , Tennant Ryan , Guirguis Lisa , Grindrod Kelly
Published: July 2020

BACKGROUND

In North America, although pharmacists are obligated to ensure prescribed medications are appropriate, information about a patient’s reason for use is not a required component of a legal prescription. The benefits of prescribers including the reason for use on prescriptions is evident in the current literature. However, it is not standard practice to share this information with pharmacists.

OBJECTIVE

Our aim was to characterize the research on how including the reason for use on a prescription impacts pharmacists.

METHODS

We performed an interdisciplinary scoping review, searching literature in the fields of health care, informatics, and engineering. The following databases were searched between December 2018 and January 2019: PubMed, Institute of Electrical and Electronics Engineers (IEEE), Association for Computing Machinery (ACM), International Pharmaceutical Abstracts (IPA), and EMBASE.

RESULTS

A total of 3912 potentially relevant articles were identified, with 9 papers meeting the inclusion criteria. The studies used different terminology (eg, indication, reason for use) and a wide variety of study methodologies, including prospective and retrospective observational studies, randomized controlled trials, and qualitative interviews and focus groups. The results suggest that including the reason for use on a prescription can help the pharmacist catch more errors, reduce the need to contact prescribers, support patient counseling, impact communication, and improve patient safety. Reasons that may prevent prescribers from adding the reason for use information are concerns about workflow and patient privacy.

CONCLUSIONS

More research is needed to understand how the reason for use information should be provided to pharmacists. In the limited literature to date, there is a consensus that the addition of this information to prescriptions benefits patient safety and enables pharmacists to be more effective. Future research should use an implementation science or theory-based approach to improve prescriber buy-in and, consequently, adoption.
A Picture Is Worth a Thousand Views: A Triple Crossover Trial of Visual Abstracts to Examine Their Impact on Research Dissemination (Preprint)
Authors: Oska Sandra , Lerma Edgar , Topf Joel
Published: July 2020

BACKGROUND

A visual abstract is a graphic summary of a research article’s question, methods, and major findings. Although they have a number of uses, visual abstracts are chiefly used to promote research articles on social media.

OBJECTIVE

This study aimed to determine if the use of visual abstracts increases the visibility of nephrology research shared on Twitter.

METHODS

A prospective case-control crossover study was conducted using 40 research articles published in the American Journal of Nephrology (AJN). Each article was shared by the AJN Twitter account in 3 formats: (1) the article citation, (2) the citation with a key figure from the article, and (3) the citation with a visual abstract. Tweets were spaced 2 weeks apart to allow washout of the previous tweet, and the order of the tweets was randomized. Dissemination was measured via retweets, views, number of link clicks, and Altmetric scores.

RESULTS

Tweets that contained a visual abstract had more than twice as many views as citation-only tweets (1351, SD 1053 vs 639, SD 343) and nearly twice as many views as key figure tweets (1351, SD 1053 vs 732, SD 464). Visual abstract tweets had 5 times the engagements of citation-only tweets and more than 3.5 times the engagements of key figure tweets. Visual abstract tweets were also associated with greater increases in Altmetric scores as compared to citation-only tweets (2.20 vs 1.05).

CONCLUSIONS

The use of visual abstracts increased visibility of research articles on Twitter, resulting in a greater number of views, engagements, and retweets. Visual abstracts were also associated with increased Altmetric scores as compared to citation-only tweets. These findings support the broader use of visual abstracts in the scientific community. Journals should consider visual abstracts as valuable tools for research dissemination.
Mobile Phone Apps in Australia for Improving Pregnancy Outcomes: Systematic Search on App Stores (Preprint)
Authors: Musgrave Loretta M , Kizirian Nathalie V , Homer Caroline S E , Gordon Adrienne
Published: July 2020

BACKGROUND

Women are increasingly turning to mobile health platforms to receive health information and support in pregnancy, yet the content of these platforms vary. Although there is great potential to influence health behaviors, little research has assessed the quality of these platforms or their ability to change behavior. In recent years, validated tools to assess app quality have become available.

OBJECTIVE

To identify and assess the quality and ongoing popularity of the top 10 freely available pregnancy apps in Australia using validated tools.

METHODS

A systematic search on app stores to identify apps was performed. A Google Play search used subject terms pregnancy, parenting, and childbirth; the iTunes search used alternative categories medical and health and fitness. The top 250 apps from each store were cross-referenced, and the top 100 found in both Google Play and iTunes were screened for eligibility. Apps that provided health information or advice for pregnancy were included. Excluded apps focused on nonhealth information (eg, baby names). The top 10 pregnancy apps were assessed using the Mobile App Rating Scale (MARS). A comparative analysis was conducted at 2 time points over 2 years to assess the ongoing popularity of the apps. The MARS score was compared to the download and star rating data collected from iTunes and Google Play in 2017 and 2019. Health behaviors including breastfeeding, healthy pregnancy weight, and maternal awareness of fetal movements were reviewed for apparent impact on the user’s knowledge, attitudes, and behavior change intentions using the MARS perceived impact section and the Coventry, Aberdeen, and London—Refined (CALO-RE) taxonomy.

RESULTS

A total of 2052 free apps were screened for eligibility, 1397 were excluded, and 655 were reviewed and scored. The top 10 apps were selected using download numbers and star ratings. All 10 apps were suboptimal in quality, practicality, and functionality. It was not possible to identify a primary purpose for all apps, and there was overlap in purpose for many. The mean overall MARS app quality score across all 10 apps was 3.01 (range 1.97-4.40) in 2017 and 3.40 (range 2.27-4.44) in 2019. A minority of apps scored well for perceived impact on health behavior using the MARS tool. Using the CALO-RE 40 item taxonomy, the number of behavior change techniques used was low. The mean number of behavior change techniques for breastfeeding was 5 (range 2-11), for pregnancy weight was 4 (range 2-12), and for maternal awareness of fetal movements was 5 (range 2-8).

CONCLUSIONS

This review provides valuable information to clinicians and consumers about the quality of apps currently available for pregnancy in Australia. Consideration is needed regarding the regulation of information and the potential opportunity to incorporate behavior change techniques to improve maternal and fetal outcomes.
THEORETICAL KNOWLEDGE DIFFERENCE BETWEEN INTERNET-BASED AND DIGITAL STORYTELLING EDUCATION ABOUT BREAST CANCER: Observational Study (Preprint)
Authors: Aydin Aydanur
Published: July 2020

UNSTRUCTURED

Previous research has identified the theoretical knowledge of nursing students and stated that new methods are needed in education. To evaluate the effect of education on the theoretical knowledge of students through internet-based or digital storytelling. Quasi-experimental study with comparison groups and pre- and post-measurements. In the internet-based education group 68 and digital storytelling video 66 undergraduate nurses were included the study. Data for the study were gathered, before education and after eight weeks. The percentages were calculated at for every measurement, and the Wilcoxon test was used to detect statistical significance of changes between measurements. The increase of knowledge scores was more often statistically significant in the internet-based education than in the digital storytelling video. The difference theoretical knowledge was higher among the internet-based education program than among those not receiving it.
COVID-19 Outbreak and Management Approach for Families with Children on Long-Term Kidney Replacement Therapy
Authors: Zhao Rui , Zhou Qing , Wang Xiao-Wen , Liu Cui-Hua , Wang Mo , Yang Qing , Zhai Yi-Hui , Zhu Da-Qian , Chen Jing , Fang Xiao-Yan , Tang Xiao-Shan , Zhang Hui , Shen Qian , Xu Hong
Published: July 2020

Background and objectives

During the coronavirus disease 2019 outbreak, the treatment of families with children on long-term KRT is challenging. This study was conducted to identify the current difficulties, worries regarding the next 2 months, and mental distress experienced by families with children on long-term KRT during the coronavirus disease 2019 outbreak and to deliver possible management approaches to ensure uninterrupted treatment for children on long-term KRT.

Design, setting, participants, & measurements

A multicenter online survey was conducted between February 10 and 15, 2020, among the families with children on long-term KRT from five major pediatric dialysis centers in mainland China. The primary caregivers of children currently on long-term KRT were eligible and included. Demographic information, severe acute respiratory syndrome coronavirus 2 infection status, current difficulties, and worries regarding the next 2 months were surveyed using a self-developed questionnaire. The Patient Health Questionnaire-9 and the General Anxiety Disorder Scale-7 were used to screen for depressive symptoms and anxiety, respectively.

Results

Among the children in the 220 families included in data analysis, 113 (51%) children were on dialysis, and the other 107 (49%) had kidney transplants. No families reported confirmed or suspected cases of coronavirus disease 2019. Overall, 135 (61%) and 173 (79%) caregivers reported having difficulties now and having worries regarding the next 2 months, respectively. Dialysis supply shortage (dialysis group) and hard to have blood tests (kidney transplantation group) were most commonly reported. A total of 29 (13%) caregivers had depressive symptoms, and 24 (11%) had anxiety. After the survey, we offered online and offline interventions to address their problems. At the time of the submission of this paper, no treatment interruption had been reported.

Conclusions

The coronavirus disease 2019 outbreak has had physical, mental, logistical, and financial effects on families with children on long-term KRT.
ГИРОКАРДИОГРАФИЯ КАК СПОСОБ НЕИНВАЗИВНОЙ ДИАГНОСТИКИ ЗАБОЛЕВАНИЙ
Authors: Ачильдиев В.М. , Бедро Н.А. , Грузевич Ю.К. , Евсеева Ю.Н. , Комарова М.Н. , Рулев М.Е. , Солдатенков В.А. , Успенский В.М.
Published: July 2020

Доклад посвящен возможности использования гирокардиограммы для неинвазивной диагностики заболеваний человека. Описаны оптимальные параметры микромеханического гироскопа для регистрации гирокардиограммы, исследовано изменение форм сейсмокардиограммы и гирокардиограммы во времени, а также выполнен визуальный сравнительный анализ по схеме, предложенной Кроу.

The report is devoted to the possibility of using a gyrocardiogram for noninvasive diagnosis of human diseases. The optimal features of a MEMS gyroscope for gyrocardiogram measurement have been presented, the issue of changing a seismocardiogram and gyrocardiogram forms over time has been considered, and a visual comparative analysis using the scheme proposed by Crow has been performed.
ОПТИМИЗАЦИЯ ПАРАМЕТРОВ ПЛАНАРНЫХ ЭЛЕКТРОХИМИЧЕСКИХ ПРЕОБРАЗОВАТЕЛЕЙ
Authors: Жевненко Д.А. , Горнев Е.С. , Криштоп Т.В. , Криштоп В.Г.
Published: July 2020

Исследовано влияние основных геометрических параметров планарных электрохимических преобразователей на выходные характеристики. Смоделированы процессы переноса в электрохимическом преобразователе при различных геометрических параметрах преобразователя и изучена зависимость стационарного тока в системе от ее параметров.

The paper studies the influence of the basic geometric parameters on the output characteristics of planar electrochemical transducers. Transport processes in electrochemical transducers with various geometric parameters and the dependence of the stationary current on them have been simulated.
ТРЕХМЕРНЫЕ МНОГОФУНКЦИОНАЛЬНЫЕ ГИБРИДНЫЕ СБОРКИ В МИКРОЭЛЕКТРОНИКЕ
Authors: Итальянцев А.Г. , Захаров П.С.
Published: July 2020

Представлены основные конструктивные и технологические особенности 3D МФГС. Показано, что процесс их разработки связан с решением комплекса противоречивых задач. Разработана унифицированная технология, позволяющая с минимальными временными и материальными затратами переходить от партии к партии 3D МФГС различного назначения.

The paper presents basic constructive and technological features of 3D multifunctional hybrid packages. It is shown that design process of such packages is affected by a variety of contradictory challenges. As a result, a basic process that allows fast and cheap 3D multifunctional hybrid packages assembly reconfiguration has been developed.
АНАЛИЗ МЕТОДОВ МАТЕМАТИЧЕСКОГО МОДЕЛИРОВАНИЯ МЕМРИСТОРОВ
Authors: Мещанинов Ф.П. , Горнев Е.С. , Кожевников В.С. , Жевненко Д.А.
Published: July 2020

В работе рассматриваются различные методы моделирования мемристоров и мемристивных структур. Для каждой модели выполнено численное моделирование и сравнение с экспериментальными результатами. Для этого была разработана метрика и критерии сравнения моделей между собой.

The paper considers various modeling techniques for memristors and memristive structures. For each model, numerical modeling and comparison with experimental results have been performed. To that end, a metric and criteria for comparing models with each other have been developed.
ФИЗИЧЕСКИЕ ПРИНЦИПЫ ЭНЕРГОНЕЗАВИСИМОЙ ПАМЯТИ И ЛОГИКИ НА ПРИНЦИПАХ СПИНТРОНИКИ И СЕГНЕТОЭЛЕКТРИЧЕСТВА ДЛЯ НЕЙРОМОРФНЫХ СИСТЕМ
Authors: Морозова М.А. , Матвеев О.В. , Романенко Д.В.
Published: July 2020

Исследованы резонансные и нелинейные эффекты в композитных мультиферроидных структурах на основе магнонных кристаллов и сегнетоэлектриков. Предложены принципы использования таких структур в качестве энергонезависимой сегнетоэлектрической памяти, а также устройств обработки сигналов.

The paper highlights resonance and nonlinear effects in composite multiferroic structures based on magnonic crystals and ferroelectrics. The principles of using such structures as non-volatile ferroelectric memory, as well as signal processing devices, have been proposed.
Trayectorias de desarrollo profesional docente para un uso pedagógico de la argumentación a partir del uso de soportes curriculares digitales
Authors: Calderón Soto Maribel , Silva Barrueto Maximiliano , Villavicencio Rojas María Constanza , Larrain Sutil Antonia , Ramos Araya María Cecilia , Tapia Silva Hugo , Sánchez Álvaro , Moreno Consuelo , Morán Ramírez Camila
Published: July 2020

El presente artículo tiene como objetivo describir las transformaciones de prácticas pedagógicas y uso pedagógico de la argumentación en docentes, a partir del apoyo de materiales curriculares soportados tecnológicamente con un software piloto denominado argumentApp. Se utilizó una metodología cualitativa, mediante el estudio de cuatro casos de profesores y estudiantes de cuatro escuelas de la Región Metropolitana en Chile. Los datos, recogidos mediante observaciones de clases y entrevistas en profundidad, indican que los docentes incorporaron prácticas colaborativas en el aula y produjeron un mayor número de preguntas de argumentación. Se observan diferencias en el modo de apropiarse de la herramienta tecnológica y de su aporte a la dinámica de aprendizaje en el aula. Los resultados se discuten considerando el aporte de intervenciones de desarrollo profesional situadas en un contexto concreto de práctica y las dimensiones que permiten construir una intervención que favorezca una enseñanza dialógica.
Conocimientos de docentes de primaria en formación respecto a perímetro y área de polígonos
Authors: González Peralta Angelina Guadalupe , Sánchez Aguilar Mario
Published: July 2020

El objetivo de la investigación que reportamos es analizar el conocimiento que docentes de primaria en formación ponen en juego al resolver problemas de perímetro y área de polígonos. Para este propósito, elegimos doce tareas matemáticas: dos vinculadas a conocimientos factuales sobre perímetro y área, cuatro relativas a la comprensión de estos conceptos y seis enfocadas a explorar el uso de procedimientos rutinarios. Junto con el instrumento, diseñamos un código que permitiera realizar una categorización y análisis de las respuestas escritas de los participantes. En este estudio cualitativo participaron 39 estudiantes mexicanos de la licenciatura en Educación Primaria de una escuela Normal. Al analizar las respuestas de los sujetos de estudio identificamos dificultades para proporcionar definiciones formales de los conceptos de perímetro y área, además de que parecen estar más familiarizados con el uso de procedimientos de rutina que con la comprensión de los conceptos.
Políticas de formación docente en Colombia, 1976-2018
Authors: Jiménez Becerra Absalón
Published: July 2020

Las políticas de formación docente representan un escenario de tensión y lucha entre el Estado colombiano, las Escuelas Normales y las Facultades de Educación, en el que está en juego un interés burocrático, modernizante y de desmonte de estas instituciones, acompañadas de iniciativas de ajuste, complemento y direccionamiento por parte del sector de profesores y del magisterio como gremio. Las instituciones formadoras de docentes se han visto abocadas, a través de sus asociaciones y grupos de intelectuales, a participar de manera constante en dicho escenario, entre 1976 y 2018, con el objetivo de establecer los principios orientadores que definen al docente como un profesional inacabado y en permanente formación, como también el peso transversal que tiene la pedagogía y la práctica pedagógica en su proceso formativo.
Penerapan Media Pembelajaran Software PSIM Pada Mata Pelajaran Dasar Listrik Dan Elektronika
Authors: Lastya Hari Anna
Published: July 2020

Pendidikan pada era globalisasi saat ini semakin meningkat seiring dengan perkembangan zaman, sehingga penerapan software dalam kegiatan pembelajaran akan membuat sistem pembelajaran menjadi lebih canggih. Hasil dari observasi pada peserta didik kelas XI SMK N 2 Banda Aceh dalam kegiatan pembelajaran belum sering menggunakan software sebagai penunjang pembelajaran, sehingga peserta didik tidak memiliki kemampuan dalam melakukan simulasi. Penelitian ini dilakukan dengan tujuan untuk melihat tingkat keberhasilan hasil belajar peserta didik dengan diterapkan pembelajaran menggunakan media software PSIM. Penelitian ini merupakan penelitian kuantitatif dengan metode quasi eksperimen dan dengan pre-test dan post-test desain. Data dalam penelitian ini dikumpulkan dengan menggunakan instrumen lembar pre-test, lembar post-test dan lembar kuesioner. Hasil dari data pada instrumen tersebut dianalisis menggunakan uji t-test untuk melihat tingkat keberhasilan kemampuan peserta didik. Hasil analisis membuktikan bahwa terdapat perubahan hasil belajar yang signifikan yang dapat dilihat dari hasil nilai rata-rata pre-test dan post-test peserta didik yaitu (38.3 < 83.9), dan nilai pengaruh dari pembelajaran dengan presentase sebesar 33.4%. Sehingga dari hasil tersebut yang bahwa Ho ditolak dan Ha diterima. Dengan demikian dapat disimpulkan bahwa penerapan media pembelajaran menggunakan software PSIM ini dapat meningkatkan hasil belajar peserta didik kelas XI TITL di SMK N 2 Banda Aceh.
Light olefin production using the mixture of HZSM-5/MCM-41 and γ-Al2O3 as catalysts for catalytic pyrolysis of waste tires
Authors: Fu Ruru , He Zhuangzhang , Qin Shikai , Jiao Qingze , Feng Caihong , Li Hansheng , Zhao Yun
Published: July 2020

In this paper, micro-mesoporous HZSM-5/MCM-41 zeolites were prepared by a two-step hydrothermal method using commercial HZSM-5 with two different silica/alumina ratios (38 and 50) as starting materials. The structures, morphologies and acidity of as-prepared zeolites were analyzed using XRD, FT-IR, SEM, N2-adsorption/desorption and NH3-TPD. The HZSM-5/MCM-41 zeolites combined the acidity of microporous HZSM-5 with the pore advantages of mesoporous MCM-41. Mesopores and microspores of 3.34 and 0.95 nm in diameter were found to be present in HZSM-5/MCM-41 zeolites. When they were used to catalyze the pyrolysis of waste tires, the selectivity of light olefins for HZSM-5/MCM-41 prepared using HZSM-5 with the silica/alumina ratio of 50 as starting materials was 21.42%, higher than 18.43% of HZSM-5/MCM-41 synthesized using HZSM-5 with the silica/alumina ratio of 38. In order to further overcome the pore size constraints and mass transfer limitations of HZSM- -5/MCM-41 zeolites for catalyzing pyrolysis of waste tires, macroporous ?-Al2O3 were mixed with HZSM-5/MCM-41 and used as catalysts. The selectivity to light olefins for the mixture of ?-Al2O3 and HZSM-5/MCM-41 prepared using HZSM-5 with the silica/alumina ratio of 50 as starting materials was 33.65%, which was obviously enhanced by the introduction of ?-Al2O3.
Investigating Accountants' Resistance to Move beyond Excel and Adopt New Data Analytics Technology
Authors: Schmidt Pamela J. , Riley Jennifer , Swanson Church Kimberly
Published: July 2020

SYNOPSIS

A call to action has been sounded in accounting: Become a profession utilizing data analytics or become a profession bound for the history books. Accounting firms and corporations are investing in data analytics capabilities, but it is not clear whether accounting professionals are following their lead. Practitioner press indicates accountants resist the move beyond Excel even as organizations hire data scientists rather than accountants. This empirical study uses Status Quo Bias Theory to examine the resistance to data analytics technology by accounting and finance professionals. Surprisingly results indicate the perceived value does not mediate the effect of switching benefits and costs on resistance. Rather, switching benefits and perceived value are aligned as a single factor to reduce resistance while switching costs directly increase resistance. Researchers have focused substantial efforts toward data analytics in education and business. The troubling findings here suggest some accounting professionals resist adopting new analytics technology.

JEL Classifications: M41; M49.

Data Availability: Contact the authors.
Transverse dentoalveolar response of mandibular arch after rapid maxillary expansion (RME) with tooth-borne and bone-borne appliances:
Authors: Lo Giudice Antonino , Ronsivalle Vincenzo , Lagravere Manuel , Leonardi Rosalia , Martina Stefano , Isola Gaetano
Published: July 2020

Objectives

To assess and compare spontaneous expansion of mandibular posterior teeth between tooth-borne (TB) and bone-borne (BB) rapid maxillary expansion (RME).

Materials and Methods

This study included 36 adolescents with bilateral maxillary crossbite receiving tooth-borne (average age: 14.4 ± 1.3 years) or bone-borne (average age: 14.7 ± 1.4 years) maxillary expansion. Cone beam computed tomography was acquired before expansion (T1) and after 6 months' retention (T2). Specific linear and angular measurements were performed in the coronal view to assess buccal inclinations and widths of mandibular posterior units. All data were statistically analyzed.

Results

In both groups there was a significant increase in buccal-lingual inclination of mandibular posterior teeth ranging from 1.67° to 2.30° in the TB group and from 1.46° to 2.11° in BB group. Mandibular posterior widths showed an increase ranging from 0.80 mm to 1.33 mm in TB group and from 0.64 mm to 0.96 mm in the BB group. No differences between groups were found for linear or angular measurements.

Conclusions

A clinically significant gain of space in the mandibular arch should not be expected after RME.
Superflex: Innovative Learning to Develop Social Attitude Competencies
Authors: Rachmah Huriah , Gunawan Rudy , Hendrawan Jajang Hendar
Published: July 2020

The 2013 curriculum aims to produce students to have three competencies: attitude, knowledge and skills.  Competence of attitude is divided into two, namely spiritual and social. Competence of social attitude is done during the learning process and assessment. But not on all subjects, the process and attitude assessment is done by the teacher. Assessment of attitudes in primary schools is done by classroom teachers, teachers of religious instruction lessons, PJOK, and extracurricular coaches. Social attitude is an integral part of social thinking because attitude is the fruit of thought. Learning Superflex® is a model developed in 2008 in the United States and in this research is adapted to help address issues related to social attitudes. This research uses descriptive analysis method. Some of the data is taken from the results of research that the author did and still runs until this year. The data is collaborated with the data obtained from the literature to produce this study. The conclusion of this study that innovative learning model depends on the creativity of teachers in generating motivation learners. The Superflex® learning model can be an inspiration for teachers as one of the innovative learning models that can build students' social attitudes.
PENGARUH PEMBELAJARAN QUANTUM BERBASIS KEARIFAN LOKAL TAT TWAM ASI TERHADAP KOMPETENSI PENGETAHUAN PKN SISWA KELAS IV SD GUGUS PB. SUDIRMAN DENPASAR BARAT
Authors: Indah Pradnyani Gusti Ayu Made , Kristiantari MG. Rini , Sri Asri I G.A. Agung
Published: July 2020

Penelitian ini bertujuan untuk mengetahui perbedaan yang signifikan kompetensi pengetahuan PKn antara siswa kelas IV SD Gugus PB. Sudirman Denpasar Barat tahun ajaran 2016/2017 yang mengikuti pembelajaran Quantum berbasis kearifan lokal Tat Twam Asi dan yang mengikuti pembelajaran secara konvensional (pendekatan saintifik). Populasi penelitian adalah siswa kelas IV di Gugus PB. Sudirman Denpasar Barat. Sampel penelitian yaitu siswa kelas IVA SDN 6 Dauh Puri sebagai kelompok eksperimen dan siswa kelas IVB SDN 6 Dauh Puri sebagai kelompok kontrol. Data hasil kompetensi pengetahuan PKn siswa dikumpulkan dengan instrumen tes (pilihan ganda). Kemudian data dianalisis menggunakan analisis statistik deskriptif dan statistik inferensial uji-t. Berdasarkan hasil analisis data, diperoleh thitung = 2,30 > ttabel (pada taraf signifikansi 5%) = 2,000, dapat diinterprestasikan bahwa terdapat perbedaan yang signifikan kompetensi pengetahuan PKn antara kelompok siswa yang mengikuti pembelajaran quantum berbasis kearifan lokal tat twam asi dan kelompok siswa yang mengikuti pembelajaran secara konvensional. Dengan demikian dapat disimpulkan bahwa pembelajaran quantum berbasis kearifan lokal tat twam asiberpengaruh terhadap kompetensi pengetahuan siswa kelas IV SD Gugus PB. Sudirman Denpasar Barat Tahun Ajaran 2016/2017
PENGARUH MODEL PEMBELAJARAN GROUP INVESTIGATION BERNUANSA OUTDOOR STUDY TERHADAP PENGUASAAN KOMPETENSI PENGATAHUAN IPA KELAS IV
Authors: Krishna Dewi Gusti Ayu Putu Ary , Putra I Ketut Adnyana , Negara I Gusti Agung Oka
Published: July 2020

Penelitian ini bertujuan untuk mengetahui pengaruh yang signifikan penguasaan kompetensi pengetahuan IPA antara kelompok siswa yang dibelajarkan dengan model pembelajaran group investigation bernuansa outdoor study dan kelompok siswa yang dibelajarkan dengan pembelajaran konvensional pada kelas IV SD Negeri Gugus Jendral Sudirman Denpasar  Tahun Ajaran 2016/2017. Sampel penelitian adalah Kelas IV SD Negeri 6 Sesetan  sebagai kelompok eksperimen dan Kelas IV SD Negeri 13 Sesetan sebagai kelompok kontrol. Data yang dikumpulkan dan dianalisis menggunakan uji t. Hasil penelitian yang diperoleh menunjukkan bahwa rata-rata penguasaan kompetensi pengetahuan IPA pada kelompok eksperimen yaitu 81,93 dan rata-rata kelompok kontrol yaitu 68,37. Setelah diuji dengan uji t, diperoleh t hitung yaitu 5,33 > t tabel 1,980 (taraf signifikansi 5%, dk 46+46-2 = 90), maka Ho ditolak dan Ha diterima. Dapat disimpulkan bahwa terdapat pengaruh yang signifikan penguasaan model pembelajaran group investigation bernuansa outdoor study terhadap penguasaan kompetensi pengetahuan IPA antara kelompok siswa yang dibelajarkan dengan model pembelajaran group investigation bernuansa outdoor study dan  kelompok siswa yang dibelajarkan dengan pembelajaran konvensional