bluuebunny/crossref_metadata_2025 huggingface dataset:
Theodor Lipps (1851-1914): psychologie, philosophie, esthétique, langage/psychology, philosophy, aesthetics, language
Authors: Romand David , Tchougounnikov Serge
Published: February 2022

Le présent volume, qui regroupe les contributions de sept auteurs, est le premier ouvrage à proposer une réflexion d'ensemble sur les multiples aspects constitutifs de la pensée de Theodor Lipps (1851-1914). Figure majeure de la philosophie, de la psychologie et de l'esthétique allemandes de la fin du XIXe siècle et du début du XXe siècle, Lipps est l'auteur d'une œuvre étonnamment abondante et variée dont l'importance et la portée historiques apparaissent aujourd'hui singulièrement minorées. C'est donc non pas seulement au développement mais au renouvellement des études lippsiennes que le présent volume entend contribuer, son objectif étant ici d'offrir au lecteur une vision plus ample et plus diversifiée, plus personnelle aussi, de la pensée de Lipps, en s'intéressant à de nombreux pans de son œuvre restés jusqu'ici injustement négligés et s'efforçant de les reconsidérer à la lumière d'une grande variété de contextes.
Ações direcionadas à permanência do estudante universitário
Authors: Fiorin Bruna Pereira Alves , Pavão Sílvia Maria de Oliveira
Published: February 2022

Esta pesquisa teve por objetivo identificar as ações voltadas à permanência do estudante universitário em três Universidades Federais do Rio Grande do Sul, buscando evidenciar a efetividade dos serviços de apoio e as ações com melhores resultados/maior impacto. A pesquisa, de cunho qualitativo, foi desenvolvida a partir de dados coletados nas páginas institucionais da Universidade Federal de Pelotas, Universidade Federal de Santa Maria e Universidade Federal do Pampa, em entrevista semiestruturada (gravada em áudio e transcrita) com os 15 coordenadores dos setores que desenvolviam atividades voltadas à permanência dos estudantes nessas Instituições, e grupo de discussão. Os dados foram analisados a partir da Análise de Conteúdo. Evidenciou-se que os setores pesquisados desenvolvem um trabalho essencial nas Instituições e que interferem diretamente na trajetória dos acadêmicos na universidade, na permanência e na conclusão de curso.
Estudos sobre a formação da enfermeira para o cuidado
Authors: Barbosa Elane da Silva , Nóbrega-Therrien Silvia Maria
Published: February 2022

O cuidado de Enfermagem, embora considerado núcleo caracterizador da profissão, é colocado como algo secundário. Assim, identifica-se a necessidade de se reportar para o ensino superior em Enfermagem, para compreender como são trabalhados os fundamentos para o exercício do cuidado. Objetiva-se, então, debater sobre o processo de formação da enfermeira para o cuidado. Trata-se de estudo do tipo reflexivo, que se utiliza da perspectiva do Estado da Questão (EQ). Estabeleceram-se as seguintes fontes para levantamento dos dados: Biblioteca Virtual em Saúde (BVS); Banco de Dissertações e Teses da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) e Revista Brasileira de Enfermagem (REBEn). Em relação ao cuidado de Enfermagem, as concepções vão desde procedimentos até ação de valorização da integralidade humana. As discussões sobre a formação da enfermeira convergem, ainda que com especificidades, para o argumento de que transformações no curso levam a mudanças na atuação profissional. A formação para o cuidado na Enfermagem tem sido pesquisada sob diversos vieses: comportamento do aluno no contato com o corpo do outro que procura o serviço de Enfermagem; relação estabelecida entre profissional e usuário; estratégia para materializar a humanização no atendimento em saúde; reflexão acerca da função do professor para mediar esse aprendizado e conhecimentos abordados. Constata-se, portanto, a relevância das investigações sobre a formação da enfermeira para o cuidado, pois existem lacunas nas produções inventariadas no que concerne à perspectiva da história e valorização das singularidades desses diversos contextos no processo de ensino e aprendizagem.
Internacionalización de la educación superior
Authors: Parra-Sandoval Maria Cristina
Published: February 2022

La internacionalización de la educación superior es un tema y una estrategia que ha adquirido creciente importancia en todos los países del mundo y en las organizaciones internacionales vinculadas a la educación superior. Sin embargo, el proceso de internacionalización no es neutro ni las políticas que lo impulsan tampoco lo son, en tanto la misión tradicional de la universidad como productora y transmisora de conocimiento enfrenta retos vinculados a la presión del poder político y económico y a laorientación de sus narrativas. El artículo trata de develar qué subyace en el discurso de UNESCO y de OCDE y como ello influye en el proceso de internacionalización de la educación superior y en las políticas que al respecto implementan los países. La conclusión es que, en la práctica,estos discursos están promoviendo un modelo especifico de universidad a emular.
Permanência no ensino superior e a rede de apoio de estudantes residentes em moradia estudantil
Authors: Lacerda Izabella Pirro , Yunes Maria Angela Mattar , Valentini Felipe
Published: February 2022

A moradia estudantil é um programa de assistência estudantil que visa promover a permanência dos discentes no ensino superior. O estudo teve como objetivo investigar a rede de apoio dos estudantes universitários residentes em moradia estudantil no que tange às relações interpessoais, qualidade dos vínculos e a função da rede de apoio. Ademais, buscou-se analisar as percepções de apoio social e a sua influência na permanência na universidade. A amostra foi composta por 20 universitários (50% mulheres), com idades entre 19 e 37 anos (M = 28, DP = 12,73). Os dados foram coletados por meio do mapa dos cinco campos, definidos como “família, amigos, moradia estudantil, universidade e colegas de quarto” e entrevista semiestruturada. Os resultados apontaram 422 contatos, com destaques para os campos amigos, família e moradia estudantil. A análise fundamentada nos dados das entrevistas resultou em três categorias: relações significativas de tutoria; sensação de proteção e despreocupações práticas e materiais. Concluiu-se que o papel da rede de apoio, destacadamente o suporte da família e dos amigos, são propulsores relacionais e protetores em diferentes situações. Ademais, a moradia estudantil pode auxiliar na superação das dificuldades encontradas na trajetória acadêmica e facilitar a permanência na universidade dos estudantes residentes.
Cenários e desafios da universidade na economia do conhecimento
Authors: Sousa José Vieira de
Published: February 2022

Neste artigo analisam-se cenários e desafios da universidade na economia do conhecimento, considerando sua inserção no campo mais amplo da educação superior formado pela pluralidade de atores e instituições interessados em sua dinâmica. A noção de campo formulada por Pierre Bourdieu constitui importante construto teórico-metodológico para análise da educação superior na sociedade contemporânea. Historicamente, a universidade revela-se como porta de entrada e espaço privilegiado para construir caminhos e soluções para desafios apresentados, ao longo do tempo, à sociedade. No mundo globalizado a universidade atua em um terreno de incertezas e contradições, ao mesmo tempo que configura um componente indiscutível para o desenvolvimento do projeto político dos países. Na competitiva educação superior contemporânea o conceito de world-class universitie vem sendo disputado e construído com base em padrões e critérios globais diretamente associados às classificações feitas pelos rankings internacionais.
DOLAVI Real-Life Study of Dolutegravir Plus Lamivudine in Naive HIV-1 Patients (48 Weeks)
Authors: Hidalgo-Tenorio Carmen , Pasquau Juan , Vinuesa David , Ferra Sergio , Terron Alberto , SanJoaquin Isabel , Payeras Antoni , Martinez Onofre Juan , Lopez-Ruz Miguel Ángel , Omar Mohamed , de la Torre-Lima Javier , Lopez-Lirola Ana , Palomares Jesus , Blanco Jose Ramón , Montero Marta , Garcia-Vallecillos Coral
Published: February 2022

Background: Objectives were to determine the real-life effectiveness and safety of DT with dolutegravir (50 mg/QD) plus lamivudine (300 mg/QD) in multiple-tablet regimen (MTR) in naïve PLHIV followed up for 48 weeks and to evaluate the compliance and satisfaction of patients. Material and methods: Open, single-arm, multicenter, non-randomized clinical trial from May 2019 through September 2020 with 48-week follow-up. Results: The study included 88 PLHIV (91% male) with mean age of 35.9 years; 76.1% were MSM. Mean baseline CD4 was 516.4 cells/uL, with viral load (VL) of 104,828 cop/mL, and 11.4% were in AIDS stage. DT started within 7 days of first specialist consultation in all patients and the same day in 84.1%; 3.4% had baseline resistance mutations (K103N, V106I+E138A, and V108I); 12.5% were lost to follow-up. At week 48, 86.3% had VL< 50 cop/uL by intention-to-treat analysis and 98.7% by per-protocol (PP) analysis. Virological failure (VF) was recorded in 1.1%, with no resistance mutation. One blip was detected in 5.2%, without VF. Three reported anxiety, dizziness, and cephalgia, respectively, at week 4 and one insomnia at week 24; none reported adverse events at week 48. Mean weight was 4 kg higher at 48 weeks (p=0.0001) and abdominal circumference 3 cm larger at 24 weeks (p=0.022). No forgetfulness occurred in 98.7% of patients. Patient satisfaction was 90/100 at 4, 24, and 48 weeks. Conclusion: Real-world data demonstrate that dolutegravir plus lamivudine in MTR is effective, safe, and satisfactory, moderately increasing weight and abdominal circumference and administrable on a test-and-treat strategy.
Methodological Flaws in Meta-Analyses of Clinical Studies on the Management of Knee Osteoarthritis with Stem Cells: a Systematic Review
Authors: Schmitz Christoph , Alt Christopher , Pearce David A. , Furia John P. , Maffulli Nicola , Alt Eckhard U.
Published: February 2022

Background: Conclusions of meta-analyses of clinical studies may substantially influence opinions of perspective patients and stakeholders in health care. Nineteen meta-analyses of clinical studies on the management of primary knee osteoarthritis (pkOA) with stem cells, published between January 2020 and July 2021, came to inconsistent conclusions regarding the efficacy of this treatment modality. It is possible that a separate meta-analysis based on an independent, systematic assessment of clinical studies on the management of pkOA with stem cells may reach a different conclusion. Methods: PubMed, Web of Science and the Cochrane library were systematically searched for clinical studies and meta-analyses of clinical studies on the management of pkOA with stem cells. All clinical studies and meta-analyses identified were evaluated in detail, as were all sub-analyses included in the meta-analyses. Results: The inconsistent conclusions regarding the efficacy of treating pkOA with stem cells in the 19 assessed meta-analyses were most probably based on substantial differences in literature search strategies among different authors, misconceptions about meta-analyses themselves, and misconceptions about the biology of stem cells. An independent, systematic review of the literature yielded a total of 183 studies, of which 33 were randomized clinical trials, including a total of 6860 patients with pkOA. However, it was not possible to perform a scientifically sound meta-analysis. Conclusion: Clinicians should interpret the results of the 19 assessed meta-analyses of clinical studies on the management of pkOA with stem cells with caution, and should be cautious of the conclusions drawn therein. Clinicians and researchers should strive to participate in FDA and/or EMA reviewed and approved clinical trials to provide clinically and statistically valid efficacy.
German eHealth Impact Questionnaire for Online Health Information Users with Multiple Sclerosis: Instrument Validation Study
Authors: Sippel Anna , Riemann-Lorenz Karin , Pöttgen Jana , Wiedemann Renate , Drixler Karin , Bitzer Eva Maria , Holmberg Christine , Lezius Susanne , Heesen Christoph
Published: February 2022

Introduction: This study aimed to validate the psychometric properties of the German eHealth Impact Questionnaire (eHIQ-G), which is divided into two independently administered and scored parts. Methods: 162 people with MS browsed one of two possible websites containing information on MS and completed an online survey. Internal consistency was assessed by Cronbach’s alpha and structural validity by Confirmatory Factor Analysis. Construct validity was examined by assessing correlations with the eHealth Literacy Questionnaire and the General Self-Efficacy Scale. Moreover, the mean difference of the eHIQ-G score between the two websites was investigated. Results: Cronbach’s alpha for the eHIQ-G subscales ranged from .833 to .885. The eHIQ-G part 1 achieved acceptable levels of goodness-of-fit indices, whereas the fit for the eHIQ-G part 2 was poor and likewise for the alternative modified models. The correlations with the reference instruments were 0.08 – 0.62 and as expected. Older age was related with lower eHIQ-G part 1 score, whereas no significant effect was found for education. Although not significant, the website ‘AMSEL’ reached higher mean scores on eHIQ part 2. Conclusion: The eHIQ-G has good internal consistency, and sufficient structural and construct validity. It will facilitate the measurement of the impact of websites providing health information.
Continuous Decline in Myocardial Infarction and Heart Failure Hospitalizations During the First 12 Months of the COVID-19 Pandemic in Israel
Authors: Lavie Gil , Wolff Sagy Yael , Hoshen Moshe , Saliba Walid , Flugelman Moshe Y
Published: February 2022

Background A decline in cardiovascular hospitalizations was observed during the initial phases of the COVID-19 pandemic. We examine the continued effect of the pandemic on cardiovascular hospitalizations and the associated mortality rates during the first year of the pandemic in Israel. Methods We conduct a retrospective cohort study using the data of Clalit Health Services, the largest healthcare organization in Israel. We divide the Corona year into six periods (three lockdowns and three post-lockdowns) and compare the incidence rates of cardiovascular hospitalizations and their 30-day mortality during each period to the previous three years. Results The number of non-STEMI hospitalizations during the first year of the pandemic was 13.7% lower than the average of the previous three years (95% CI 11%-17%); STEMI hospitalizations were 15.7% lower (95% CI 13%-19%); and CHF hospitalizations were 23.9% lower (95%, CI 21%-27%). No significant differences in 30-day mortality rates were observed for AMI patients during most of the periods, whereas the annual 30-day all-cause mortality rate of CHF was 23% higher. Conclusions Hospitalizations for AMI and CHF were significantly lower during the first year of the pandemic relative to 2017–9. Mortality rates were higher in the case of CHF patients but not in the case of AMI patients, possibly due a change in the clinical acuity of patients arriving at the hospitals. We conclude that targeted public health messaging should be implemented, together with proactive monitoring in order to identify residual disability in patients that may have received non-optimal treatment during the pandemic.
Dynamics of Community Gardening: A Catalyst for Health
Authors: Roberson, Jr. Donald N. , Kudlacek Michal
Published: February 2022

The purpose of this study is to investigate the perceived benefits of community gardening. A garden colony is a collection of adjacent plots of land primarily for the purpose of gardening. The methodology of this research consists of observations, interviews, questionnaires, and focus group. As a result of this research we found that gardening is a natural and safe way to meet the lifelong demands for a healthy life. We found specific mental and physical benefits as a result of this community gardening. We encourage communities to allow people to buy plots of land away from their homes to promote this healthy activity. The garden colony provides a place for individual renewal and restoration; this urban oasis offers a way to maintain and promote lifelong healthy living, and they are an important contribution to one’s life by adding a sense of meaning and purpose.
Chronic Pain and Opioid Prescribing: Three Ways for Navigating Complexity at the Clinical‒Population Health Interface
Authors: Sud Abhimanyu , Buchman Daniel Z. , Furlan Andrea D. , Selby Peter , Spithoff Sheryl M. , Upshur Ross E. G.
Published: February 2022

Clinically focused interventions for people living with pain, such as health professional education, clinical decision support systems, prescription drug monitoring programs, and multidisciplinary care to support opioid tapering, have all been promoted as important solutions to the North American opioid crisis. Yet none have so far delivered substantive beneficial opioid-related population health outcomes. In fact, while total opioid prescribing has leveled off or reduced in many jurisdictions, population-level harms from opioids have continued to increase dramatically.

We attribute this failure partly to a poor recognition of the epistemic and ethical complexities at the interface of clinical and population health. We draw on a framework of knowledge networks in wicked problems to identify 3 strategies to help navigate these complexities: (1) designing and evaluating clinically focused interventions as complex interventions, (2) reformulating evidence to make population health dynamics apparent, and (3) appealing to the inseparability of facts and values to support decision-making in uncertainty.

We advocate that applying these strategies will better equip clinically focused interventions as complements to structural and public health interventions to achieve the desired beneficial population health effects. (Am J Public Health. 2022;112(S1):S56–S65. https://doi.org/10.2105/AJPH.2021.306500 )
Bilateral Quadriceps Tendon Rupture and Femoral Neck Fracture After Generalized Tonic-Clonic Seizures
Authors: Örgel Dr. Marcus , Ranker Dr. Alexander , Wirries Dr. Nils , Krettek Professor Dr. Christian , Clausen Dr. Jan-Dierk , Mommsen Professor Dr. Philipp
Published: February 2022

Case:

We report on a 19-year-old male renal transplant patient with multiple medical issues who sustained simultaneous bilateral quadriceps tendon ruptures and bilateral femoral neck fractures after 2 generalized tonic-clonic seizures. The quadriceps tendon ruptures were detected early surgically repaired; the femoral neck fractures were not detected and managed with bilateral total hip arthroplasty for almost 2 weeks.

Conclusion:

Tonic-clonic seizures can be associated with unique and complex acute orthopaedic injuries that can be initially missed. Physicians should be cognizant of the need for a thorough medical history and physical examination to avoid orthopaedic postseizure missed diagnoses.
Ms. AQUEOUS AND ETHANOLIC EXTRACTS OF TRACHY SPERMUM AMMI EXHIBIT COMPARABLE ANTIDEPRESSANT AND ANXIOLYTIC EFFECT TO IMIPRAMINE HYDROCHLORIDE AND DIAZEPAM
Authors:   Dr. Humera Khatoon, Aziz Samreen
Published: February 2022

The importance of herbal medicines in treating various ailments or diseases is phenomenal and cannot be denied due to their safe use and efficacy; Trachyspermum ammi commonly known as ajwain belongs to the family Umbelliferae and a commonly used spice in home cooking. It contains various phytoconstituents which have several pharmacological effects against a number of diseases.
35 Yıllık Sosyal Sorumluluk Araştırmalarının Analizi: Yüksek Lisans ve Doktora Tezlerinin İncelenmesi
Authors: HOŞTUT Sibel , SIRSAT Sevda , ARSLAN Özge
Published: February 2022

Sosyal sorumluluk kavramının kapsam alanı hem kurumsal düzeyde hem de akademide net olmadığından kavramın sınırlarını belirlemek oldukça güçtür. Bu konuya açıklık getirebilmek, çalışmaların tematik dağılımına ve literatür yapısına ilişkin açıklamalar yapabilmek için Türkiye’de son 35 yılda sosyal sorumluluk konusunda yazılan lisansüstü tezler bibliyometrik analiz ve içerik analizi teknikleriyle incelenmiştir. Sosyal sorumluluk kavramının merkezinde işletme literatürünün olması, lisansüstü tezlerin %90’ının Sosyal Bilimler Enstitüsü’nde ve %40’ının İşletme Ana Bilim Dalı’nda yazılmasını açıklamaktadır. Çalışmaların başlıkları arasında önemli bir kümeyi Türkiye özelinde özel sektöre ilişkin sosyal sorumluluk uygulamalarının markaya/kurum imajına, kurumsal itibara, etik değerlere ve finansal performansa etkisi ve ilişkisi oluşturmaktadır. Kurum paydaşlarından en fazla çalışma tüketicilerin satın alma davranışları ile çalışanların kuruma bağlılık ilişkisine yöneliktir. Sektör konusunda ise turizm ve bankacılık sektörlerine özel ilgi gösterilmiş, ancak diğer sektörler yeterince araştırılmamıştır. Ayrıca sivil toplum kuruluşları, gönüllülük, uluslararası standartlar gibi konular çok sınırlı sayıda çalışılmıştır. En sık atıf yapılan yazarlar listesinde yer alan A.B. Carroll, hem en sık atıf alan ilk üç makalenin yazarı olarak hem de diğer yazarlarla arasında oldukça belirgin bir farkla sıralamada birinci sırada yer alarak tek baskın yazar olarak bulgulanmıştır.
Individual and Community Level Factors Related to HIV Diagnosis, Treatment, and Stigma in Kumasi, Ghana: A Field Report
Authors: Mosley Cameran , Ofori Emmanuel , Andrews Caylin , Armstrong-Mensah Elizabeth
Published: February 2022

The human immunodeficiency virus (HIV) is a public health issue globally and in Ghana. While efforts are underway to reduce HIV prevalence in Ghana, there are still some HIV-related issues (duration lived with HIV, mode of HIV diagnosis, HIV status disclosure, HIV treatment, HIV knowledge, and HIV prevention and stigma) that need to be addressed. The purpose of the field study was to examine individual and community level factors related to HIV diagnosis, treatment, and stigma in Kumasi, Ghana. Specifically, we conducted a field-based comparison of HIV-related issues in Kumasi and the US to determine areas of similarities and differences. Since our focus was the Kumasi district in general, and the Suntreso Government Hospital in particular, we used convenient sampling. Thus, study results are not generalizable to the entire population of Ghana. Given the short duration of the entire field study (three weeks) and the fact that most information on the HIV-related issues focused in Ghana are available in the US, secondary data from various sources were used for the US comparison. Results from the study showed that 29.2% of participants in Kumasi had lived with HIV for seven or more years, while data from the US showed that people generally live with HIV for 20 years or more after testing positive for the disease. Most of the study participants in Kumasi (68.5%) stated that they were diagnosed with HIV through a laboratory blood sample test, while rapid antibody and ELISA (enzyme-linked immunosorbent assay) tests were found to be the most commonly used methods in HIV diagnosis in the US. The majority of participants living with HIV in Kumasi (71.7%) and the US (67%) were concerned about their friends and family knowing of their HIV status. Unlike the US where patient assisted programs administered by pharmaceutical companies offer free to lowly priced HIV medication to low-income people living with HIV (PLWH), 92.7% of PLWH in Kumasi had free access to HIV medication. HIV-related stigma was an issue in both Kumasi and the US.
 
Copyright © 2022 Mosley et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License CC BY 4.0.
PENGARUH APLIKASI MARBEL MEMBACA TERHADAP KEMAMPUAN MEMBACA ANAK DISLEKSIA
Authors: Surayya Shahnaz , Mubarok Husni
Published: February 2022

Pembelajaran untuk anak disleksia harus lebih menekankan pada proses belajar dimana anak disleksia dapat mengatasi kesulitan membaca, menulis atau mengeja. Namun dalam kenyataan masih banyak sekali anak disleksia yang tidak mendapat perhatian intens dalam memudahkan anak tersebut dapat membaca. Karena ketidakmampuan membaca dan menghafal abjad maka anak disleksia akan sangat tertinggal dibanding dengan anak diusianya. Berdasarkan masalah tersebut maka diperlukan adanya penelitian dengan metode eksperimen menggunakan aplikasi pembelajaran yang dapat membantu anak disleksia hafal abjad. Tujuan dari penelitian yaitu anak disleksia dapat menghafal abjad dengan baik menggunakan bantuan aplikasi Marbel Membaca. Langkah-langkah yang dilakukan oleh peneliti yaitu menentukan bahan, alat dan strateginya, menentukan tujuan penelitian, mempersiapkan kebutuhan peralatan dan sarana yang dibutuhkandanmelakukan uji eksperimen. Untuk teknik pengumpulan datanya menggunakan observasi, dokumen dan wawancara dengan bantuan angket. Lalu penelitian diukur dengan angket respon anak disleksia yang direkap menggunakan skala likert untuk mengetahui presentase pengaruh aplikasi Marbel Membaca untuk anak disleksia kemudian menggunakan rating scale untuk menafsirkan besar pengaruh aplikasi Marbel Membaca untuk anak disleksia. Berdasarkan rekap respon anak disleksia mendapat 90% atau dikategorikan anak disleksia sangat suka dan terjadi perubahan untuk hafal membaca abjad anak disleksia. Dengan demikian maka aplikasi Marbel Membaca dapat layak diterapkan dalam pembelajaran membaca untuk anak disleksia.
PENGARUH KEBIASAAN BELAJAR PESERTA DIDIK PADA FASE COVID-19 TERHADAP HASIL BELAJAR PADA MATERI AKHLAKUL KARIMAH
Authors: Prihastuti Ceci Ceci , Carlian H. Yayan , Insan Muhamadi Sani
Published: February 2022

Fase Covid-19 tentu berdampak signifikan terhadap proses belajar. Ada perubahan belajar, kebiasaan belajar, atau karena terjadi penurunan hasil belajar maka menyebabkan pergeseran cara pelaksanaan belajar yaitu melalui pemanfaatan belajar jarak jauh (PJJ). Fokus penelitian ini adalah pada hasil belajar kognitif. Tujuan dari studi ilmiah ini adalah untuk mengetahui pola belajar peserta didik selama fase Covid-19 dan hasil belajar pada materi akhlakul karimah. Studi ilmiah ini merupakan studi ilmiah kuantitatif dengan pendekatan deskriptif survey dan dilaksanakan di MI Nurussalam SM pada pengajar dan peserta didik kelas III, IV, V, dan VI yang berjumlah 40 peserta didik. Studi ilmiah ini menemukan adanya korelasi yang substansial antara praktik belajar peserta didik pada fase Covid-19 dengan hasil belajar materi akhlakul karimah. Hasil belajar ini menunjukkan perbedaan antara sebelum dan sesudah di fase Covid-19. Adapun kebiasaan belajar peserta didik selama fase Covid-19 ini, mereka menunjukkan kurangnya ketangkasan dan pendekatan kerja untuk belajar.
IMPLEMENTASI PEMBELAJARAN JARAK JAUH DENGAN MEDIA E-LEARNING (STUDI DI MADRASAH IBTIDAIYAH NEGERI 7 PONOROGO)
Authors: Afifah Anis
Published: February 2022

Kehadiran E-Learning madsarah sebagai salah satu alternatif media pembelajaran jarak jauh yang digagas oleh Direktorat Kurikulum Sarana Kelembagaan dan Kesiswaan MadrasahKementrian Agama Republik Indonesia harus diiringi dengan kesiapan guru dalam merencanakan pembelajaran. Artikel ini bermaksud untuk menganalisis implementasi pembelajaran jarak jauh dengan media E-Learning pada tahap perencanaan pembelajaran. Jenis penelitian yang digunakan adalah single-case study yaitu penelitian yang dilakukan di MIN 7 Ponorogo sebagai salah satu madrasah yang aktif dalam mengembangkan E-Learning Madrasah. Teknik pengumpulan dan analisis data menggunakan model Matthew B. Miles and A. Michael Huberman. Analisis mengacu pada konsep desain instructional Morison and Kemp yang terdiri dari empat elemen, yaitu identifikasi tujuan pembelajaran, analisis peserta didik, metode pembelajaran dan evaluasi pembelajaran. Hasil penelitian menunjukkan bahwa perencanaan pembelajaran dengan menggunakan E-Learning disusun secara sistematis sesuai dengan kurikulum yang berlaku, menyesuikan dengan kebutuhan serta kondisi peserta didik, menggunakan metode ceramah, diskusi dan penugasan. Evaluasi pembelajaran dilakukan secara berkala dan berkesinambungan sesuai dengan jadwal yang telah ditetapkan oleh madrasah.
PENDIDIKAN INTEGRITAS DALAM WACAN BOCAH MAJALAH PANJEBAR SEMANGAT: KAJIAN STRUKTURAL TEKS SASTRA ANAK BERBAHASA JAWA
Authors: Nur Hasan Latif , Pairin Udjang
Published: February 2022

Sastra anak sangat penting dalam proses pewarisan sastra, utamanya sastra Jawa karena penggunaan bahasa Jawa pada anak mulai luntur. Tidak hanya sebagai warisan sastra, dalam karya sastra anak terkandung pendidikan-pendidikan karakter yang dibutuhkan untuk perkembangan anak. Salah satunya adalah pendidikan karakter integritas yang banyak ditemukan dalam teks-teks sastra anak “wacan bocah majalah Panjebar Semangat”. Penelitian ini bertujuan untuk mengungkap nilai pendididikan integritas yang terkandung dalam wacan bocah tersebut. Pendekatan yang digunakan dalam penelitian ini adalah pendekatan terhadap teks yaitu hanya memfokuskan pada hasil karya (teks) bacaan sastra anak. Objek kajian penelitian ini adalah karya sastra anak berbahasa Jawa yang dimuat dalam Majalah Berbahasa Jawa Panjebar Semangat tahun 2020. Hasil analisis karakter integritas tersebut ditemukan ada empat jenis pendidikan karakter integritas, yaitu; 1) kejujuran, 2) keteladanan, 3) kesantunan, dan 4) cinta pada kebenaran. Keempat pendidikan karakter tersebut digambarkan baik secara implisit maupun eksplisit dalam wacan bocah.
DNA extraction protocol for low-biomass environmental samples: adapted from the Lucigen MasterPure Complete DNA and RNA Purification Kit manual
Authors: Shen Jiaxian , Hartmann Erica M.
Published: February 2022

Microbial samples collected from built environment surfaces can be very low-biomass. This poses a critical challenge to extract valid signals out of the background noises for downstream analyses. Upon comparing and optimizing several extraction methods, our results demonstrated that bead-beating and heat lysis followed by liquid-liquid extraction was the optimal method, as opposed to widely used column- and magnetic bead-based methods. Adapted from the Lucigen MasterPure Complete DNA and RNA Purification Kit manual, this protocol demonstrates detailed points that merit special attention for low-biomass environmental samples.
High Circulating Fibroblast Growth Factor-21 Levels as a Prognostic Marker in Fatty Pancreas Patients
Authors: Han Fei , Yin Ling , Yu Xiaoping , Xu Renyan , Tian Mingxiang , Liu Xinnong , Zhou Lu , Hu Lianghao , Gong Weijuan , Xiao Weiming , Lu Guotao , Yao Guanghuai , Ding Yanbing
Published: February 2022

Background: The study aimed to detect the serum levels of fibroblast growth factor-21 (FGF-21) in fatty pancreas (FP) patients and to investigate their potential clinical value.Methods: We screened patients with FP using transabdominal ultrasound. The anthropometric, biochemical and serum levels of FGF-21 were compared between the FP group and the normal control (NC) group. A receiver operating characteristic (ROC) curve was used to evaluate the predictive value of serum FGF-21 for FP patients. Results: Compared with the NC group, body mass index, fasting blood glucose levels, uric acid levels and cholesterol levels of the FP group were significantly higher, while the high-density lipoprotein level was lower. In addition, levels of serum FGF-21, resistin, leptin and tumor necrosis factor-α were significantly higher than those in the NC group, while the serum adiponectin level was lower. Pearson analysis showed serum FGF-21 levels in FP patients were negatively correlated with leptin and cholesterol. The ROC curve showed the best critical value of the serum FGF-21 level in FP patients was 187.85 pg/mL (AUC 0.716, P=0.002, 95% confidence intervals 0.611-0.820). Conclusion: Serum FGF-21 was closely related to fatty pancreas. Detecting serum FGF-21 levels may help identify the population susceptible to FP.
Genomic Machine Learning Model Predicts Radiation Therapy Benefit in Early-Stage Breast Cancer Patients with High Accuracy
Authors: Badal Kimberly , Foster Jerome E. , Haraksingh Rajini , John Melford
Published: February 2022

BackgroundRadiation therapy (RT) is frequently recommended for post-surgery treatment of early-stage breast cancer (BC) patients, though not all benefit. Clinical factors currently guide RT treatment decisions. At present, models to predict RT-benefit predominantly use statistical methods with modest performance. In this paper we present a high-accuracy genomic Machine Learning (ML) model to predict RT-benefit in early-stage BC patients. We also present a novel method for selecting genomic features for training ML algorithms. MethodsGene expression data from 463 early-stage BC patients treated with surgery and RT from the METABRIC cohort were obtained. Wilcoxon Rank Sum (Wilcoxon RS) test and Cox Proportional Hazards (Cox PH) were used to reduce the number of genes used to train eight ML algorithms. ML algorithms were trained on 80% of data using 10-fold cross validation and tested on 20% of data to assess performance in predicting relapse status. Results Genome-wide gene expression data was reduced by 96% using Wilcoxon RS and Cox PH to a 1,596 gene set and a 977 gene set. These gene sets were used to train eight ML algorithms resulting in models that ranged in performance accuracies from 54.01% to 95.6%. Highest accuracies were obtained using Support Vector Machine (SVM977–93.41%, SVM1596–95.6%) and Neural Networks algorithms (NN977 – 92.31%, NN1596 – 93.41%). In RT-untreated patients, accuracies of all models were 30% to 40% lower compared to RT-treated patients. SVM977 had the highest sensitivity of 91.09%. Members of the 977 set were enriched with genes involved in cell cycle and differentiation as well as genes associated with radiosensitivity and radioresistance.Conclusion This study presents a novel genomic feature selection approach that used Wilcoxon RS followed by Cox PH to reduce the number of genes from genome-wide gene expression data used for training ML algorithms by 96%. This approach led to an SVM model that used the expression values of 977 genes to predict RT-benefit in early-stage BC patients with 93.41% accuracy. This work demonstrates that ML models can be clinically useful for predicting cancer patient outcomes.
Performance Evaluation Of Bacterial Consortium For Biodegradation Of Total Petroleum Hydrocarbon: A Comparative Strategic Biostimulation Study
Authors: Behera Ipsita Dipamitra , Meikap Bhim Charan , Sen Ramkrishna
Published: February 2022

This research work demonstrated the comparative study of the efficacy of poultry litter extract (PLE) and inorganic fertilizer (NPK) as biostimulating agents for enhancing total petroleum hydrocarbon (TPH) degradation of petroleum refinery sludge (PRS) with bioaugmentation of an indigenously developed bacterial consortium. In this study, six sets of treatments such as natural attenuation, bioaugmentation with the indigenously developed bacterial consortium, and various biostimulation strategies with (MSM100, PLE100, NPK100, MSM50+PLE50, and MSM50+NPK50) were performed to meet 100% nutrient source for bacterial growth to enhance TPH degradation. Among all, the combined sources of MSM50+PLE50 showed the best performance by degrading the TPH up to 91.3 ± 4.1% within 28 d of the incubation period. The GC-FID analysis confirmed the efficacy of TPH degradation of PRS when PLE amendment with MSM. Further, the removal of maltene and asphaltene was also achieved 92 ± 3.7% and 52 ± 2.2% during this treatment. TPH degradation fitted to first-order kinetics with a rate constant 0.09 d-1 and half-life period of 7.7 d for MSM50+PLE50 amendment treatment along with bacterial consortium as bioaugmentation. This study revealed the implementation of the PLE amendment not only preferred as a nutrient source for bacterial growth but also enhanced TPH biodegradation in an eco-friendly strategic way by dropping the practice of inorganic salts.
The Use Of Video Consultations To Support Orthopedic Patients' Treatment At The Interface Of A Clinic And General Practitioners
Authors: Estel Katharina , Richter Luise , Weber Gordian , Fellmer Felix , Märdian Sven , Willy Christian , Back David Alexander
Published: February 2022

Introduction: Video consultations have proven to be a powerful support tool for patient–doctor interactions in general, not only during the COVID-19 pandemic. This study analyzed the feasibility and usefulness of orthopedic telemedical consultations (OTCs) for orthopedic patients at the interface of a clinic and general practitioners.Methods: The study was carried out at an orthopedic department of a German hospital between April 2020 and October 2020. After written informed consent was obtained, general practitioners (GPs) of a large adjunct health region could present their patients with orthopedic pathologies to specialists at the hospital via OTCs instead of the usual live consultation (LC). The patients, specialists and GPs were evaluated for their OTC experience and attitude (5-point Likert-scale and open questions, 19 to 27 items).Results: A total of 89 video consultations took place with 76 patients, 16 GPs and six specialists. The average distance between the GPs/patients and the hospital was 141.9 km. The OTCs were rated as pleasant, and the experience was rated as very satisfying (average Likert-Scale rating, with 5 as strong agreement: specialists = 4.8; GPs = 4.9; patients = 4.7). Following the OTC, a LC was not necessary in 76.4% of cases. Patients with a necessary LC after an OTC showed significantly lower satisfaction with the OTC (p = 0.005). Time savings, the elimination of travel and quick contact with orthopedic consultants were positively highlighted by the participants. A total of 123 recommendations for further treatment were given, such as the initiation of physiotherapy/medication and the use of imaging diagnostics. Different technical and organizational challenges could be identified and addressed.Discussion: The vast majority of the participants stated they had a very positive impression. In particular, the potential savings in travel and time as well as straightforward contact with specialists were rated positively. However, limitations in the assessment of initial presentations of complex medical conditions were also highlighted. Further studies on OTCs with a consultative health professional may specify the areas of application.
Student Experience of Distance Learning During the Sars-cov-2 Pandemic and the Prospects of its Use in A Medical University
Authors: Sankova Maria V. , Nikolenko Vladimir N. , Litvinova Tatiana M. , Volel Beatrice A. , Oganesyan Marine V. , Vovkogon Andzhela D. , Rizaeva Negoria A. , Sankov Sergey V. , Bulygin Kirill V. , Sinelnikov Mikhail Y.
Published: February 2022

Background. Medical education involves not only mastering a large amount of theoretical knowledge, but also obtaining professional practical and communication skills, which requires intramural education. In the ongoing SARS-COV-2 pandemic, most medical universities had to transform their curriculum to remote education in order to ensure the safety of students and teachers and prevent the spread of SARS-COV-2. In order to improve remote education models and determine the future prospects for its application in medical education, we studied the setbacks and advantages of remote education at a medical university during the SARS-COV-2 pandemic through surveying and academic evaluation. Methods. A survey was conducted amongst 272 first-year students at Sechenov University aged 17 to 23 years (18.47 ± 0.96 years). The work was carried out in February-March 2021 immediately after medical universities switched back to intramural studies, discontinuing remote education, which was introduced previously. The survey to assess student wellbeing, adaptive capabilities, educational preferences and burdens was developed by collaboration between Sechenov University and Moscow State University. Statistical analysis was carried out using RStudio. Results. Almost all medical students possessed digital literacy skills and showed a high level of adaptation to online learning. Teacher technical skills defined successful interaction with students in real time. The main difficulties of remote education included technical difficulties and problems associated with self-discipline and organization of working day regimen that should be taken into account when developing models of online learning. Physical wellbeing became a worrisome factor for many students. Conclusion. Remote education, though efficient in theoretical education, cannot completely replace the traditional intramural education, mainly due to hands-on training requirements. However, in the future, a transition to combined medical education, where digital technologies will find new prospects for application is anticipated.
Effects of Wolbachia elimination and B-vitamin supplementation on bed bug development and reproduction
Authors: Hickin Mauri L. , Kakumanu Madhavi L. , Schal Coby
Published: February 2022

Obligate blood feeders, such as Cimex lectualrius (common bed bug), have symbiotic associations with nutritional endosymbionts that produce B-vitamins. To quantify the symbiont’s contribution to host fitness in these obligate mutualisms, the symbiont must be eliminated and its absence rigorously confirmed. We developed and validated procedures for complete elimination of Wolbachia (Wb) in bed bugs and quantified development and reproduction in bed bugs with and without Wb and with and without B-vitamins supplementation. Aposymbiotic bed bugs had slower nymphal development, reduced adult survivorship, smaller adult size, fewer eggs per female, and lower hatch rate than bed bugs that harbored Wb. In aposymbiotic bed bugs that were fed B-vitamins-supplemented blood, nymph development time, adult survivorship and hatch rate recovered to control levels, but adult size and egg number only partially recovered. These results underscore the nutritional dependence of bed bugs on their Wb symbiont and suggest that Wb may provide additional nutritional benefits beyond the B-vitamin mix that we investigated.
The Risk of Developing Second Primary Malignancies Among Colorectal Cancer Patients
Authors: Du Songtao , Li Yayun , Sun Huiyan , Zeng Furong , Deng Guangtong , Zhang Bomiao , Cui Binbin
Published: February 2022

Background: The increasing number of young colorectal cancer (CRC) survivors has led to ongoing concerns about the risk of secondary primary malignancies (SPMs). Here, we intended to comprehensively explore the pooled standardized incidence rates (SIRs) for total and site-specific SPMs in CRC survivors with different restriction to lag period.Methods: Pubmed, Embase, Cochrane Library, and Web of science databases were searched to identify any studies reporting the SIRs of SPM following CRC until August 2021. Total and site-specific SIRs with different restriction to lag period were pooled using fixed/random effect models. Results: A total of 42 full-text publications with more than 1, 524, 236 CRC survivors and 166, 210 SPM patients were included in the meta-analysis. Pooled data showed an increased SIRs for all SPMs in CRC survivors with different restriction to lag period (no restriction to lag period, SIR = 1.15, 95%CI = [1.08-1.23]; 1-year lag, 1.16 [1.10-1.23]; 5-year lag, 1.18 [1.09-1.28]; 10-year lag, 1.24 [1.11-1.39]). The conclusions were consistent for neoplasms of colorectum, corpus uteri, and small intestine with different restriction to lag period. However, limited evidence was presented for associations between CRC survivors and SPM for prostate, breast (female), ovarian, stomach, urinary bladder, kidney, thyroid, bone and soft-tissue.Conclusion: CRC survivors are associated with an increased risk of SPMs, especially neoplasms of colorectum, corpus uteri, and small intestine. Our finding will provide the reference for patient counseling, second prevention and guidelines-making.
Elucidating tumor heterogeneity from spatially resolved transcriptomics data by multi-view graph collaborative learning
Authors: Zuo Chunman , Zhang Yijian , Cao Chen , Feng Jinwang , Jiao Mingqi , Chen Luonan
Published: February 2022

Spatially resolved transcriptomics (SRT) technology enables us to gain novel insights into tissue architecture and cell development, especially tumors. However, the lack of effective methods for exploiting biological contexts (e.g., global position information) and multi-view features has severely hindered the disentangling ability for tissue heterogeneity. Here, we proposed stMVC, a multi-view graph collaborative learning model that integrates histology, gene expression, spatial location, and biological contexts in analyzing SRT data by attention. Specifically, stMVC adopting semi-supervised graph attention autoencoder separately learns view-specific representations for each of two graphs, i.e., histological similarity graph by visual features and spatial location graph by physical coordinates, and then simultaneously integrates two-view graphs for robust representations via learning weights of different views with attention in a semi-supervision manner from biological contexts. Benchmark studies of stMVC on 12 slices from the human cortex, demonstrate its superior capability in detecting tissue structure, visualizing trajectory relationships between different layers, and denoising data. In particular, in the breast cancer study, stMVC identified new disease-related cell-states and their transition cell-states, which were further validated by the functional and survival analysis of independent clinical data. Those results not only provided novel biological insights into tumor heterogeneity but also demonstrated clinical and prognostic applications from SRT data. The software is available at https://github.com/cmzuo11/stMVC.
Saudi Arabian Students in Postgraduate Dental Programs: Investigating Factors Associated with Burnout
Authors: Asiri Amal
Published: February 2022

Burnout related to emotional and physical study or work demands affects an individual’s performance and well being. This study focused on Saudi Arabian dental residents studying in the United States and the United Kingdom who are faced with many challenges in pursuit of a higher education degree. A survey including demographic and MBI questions was distributed to assess this population’s level of burnout. The Maslach Burnout inventory (MBI) has been widely used in the literature to assess three components of burnout: emotional exhaustion (EE), depersonalization (DEP), and (diminished) personal accomplishment (PA). Potential predictors of burnout level, tested for statistical significance, included: (1) country (US vs UK), (2) hours of work, (3) sponsorship status, (4) marital status (5) gender and (6) prior work experience. Using multiple regression analyses, those found to predict EE included hours of work, sponsorship status, and gender. Only gender was found to predict PA. None of the variables were predictive of DEP. Moreover, after controlling for the demographic variables, the country where studying did not help account for the level of burnout. Limitations of the study, implications for practice and suggestions for further research are offered in the discussion.