bluuebunny/crossref_metadata_2025 huggingface dataset:
Understanding the Health Impacts of Vehicular Emissions in South Florida: A Comprehensive Analysis
Authors: Ducheine Janelle , Horesh Noah , Quinn Jason
Published: May 2024

South Florida is famous for its diverse cultural scene and year-round sunshine. This success, however, has not been without its consequences. While the region enjoys economic prosperity, the hidden cost of deteriorating air quality and adverse health effects from vehicle emissions necessitates urgent attention. Electric vehicles (EVs) have emerged as a potential solution, promising reduced emissions, and increased energy efficiency. However, the intricate life cycle emissions associated with EV energy production raise questions about their net benefits. Using predictive modeling and historical data, the study forecasts emissions trajectories and assesses their health implications. Results indicate a substantial reduction in pollutants like PM2.5 and NOx by 2050, particularly in counties with higher vehicle miles traveled (VMT). However, challenges remain, such as Broward County’s heightened dependence on polluting electricity sources for EV charging, leading to increased SO2 emissions and public health costs. The analysis underscores the importance of transitioning to cleaner energy sources, highlighting the potential benefits of renewable resources in reducing emissions and improving public health outcomes. By incorporating comprehensive data and predictive models, this study provides valuable insights for policymakers and communities, advocating for a concerted effort towards sustainable transportation solutions. Ultimately, the findings emphasize the necessity of proactive measures to mitigate the adverse effects of vehicle emissions and foster a healthier, more sustainable future for South Florida.
The State of Knowledge of CCA Diversity in the Caribbean Coral Reefs
Authors: Macias Danielle , Duran Alain , Nauer Fabio
Published: May 2024

Crustose coralline algae (CCA) are a diverse and ecologically important species found in most of the world’s oceans. The current lack of taxonomic knowledge and relative abundance compromises our ability to predict species diversity numbers and, thus, their ecological roles and impacts on coral reefs. To gather a better understanding of the state of knowledge of crustose coralline algae taxonomy in the Caribbean, 107 different research papers, and other primary and secondary literature were studied; any source with taxonomical information, species identification, or genetic markers for identification was recorded. All Genebank codes were collected and sorted by supposed species marker and then ran through the National Center of Biotechnology Information. The location these genetic markers were gathered from was compared to the natural habitat range of the species, based on the Algaebank habitat description. Of the supposed 83 described species of crustose algae in the Caribbean, based on morphological characteristics, only 24 total were confirmed by DNA markers. This leaves at least 59 species of CCA to be confirmed in the Caribbean Sea with molecular markers. This indicates the importance of DNA barcode survey studies to assess the accurate diversity of this group in the region. With this limited knowledge apparent, it should be seen that a CCAs phylogenetic and taxonomical review must be done. An in-depth assessment should be conducted on CCA collections to identify the Caribbean species correctly and thus know their biodiversity in local habitats.
Sustainability in Action: Green Infrastructure as a Marker of Sustainable Urban Development
Authors: Santiago Brianna
Published: May 2024

The current form and pace of urbanization is an ongoing threat to sustainable urban development. As these problems span social, environmental, and economic realms, it is imperative that any proposed solution is able to address these problems holistically. Although a number of silver-bullet solutions such as electric vehicle adoption have been introduced, they do not respond to the problems with an integrated approach. Tackling this problem will require a solution that can be changed and applied on a case-by-case basis. Therefore, the development of green infrastructure is the most efficient solution when responding to the problems threatening urban sustainability. The purpose of this paper is to argue for the efficacy of green infrastructure methods by analyzing the evidence provided about factors like temperature and pollution levels in green cities as compared to other proposed solutions, and to explore critiques of green infrastructure and discuss their potential improvements. The research provided contains a mixture of case studies, participant surveys, and other scientific findings and has the potential to make green infrastructure a priority in the future planning of cities.
Exploring the Evolution of Gender-Based Violence in India and its Contributing Actors
Authors: Reji Angel
Published: May 2024

Violence against women is an issue worldwide; however, this paper focuses on India, where women are at greater risk of becoming victims of violence from a range of perpetrators - including their own families, to a certain extent. Although there are various forms of violence, dowry-related domestic violence and rape are comparatively abundant, especially in coverage in the Indian news media. Despite the first feminist efforts against the violence and degradation of women nearly 50 years ago, there have yet to be any substantial changes. Throughout the history of the subcontinent — first as the Indus Valley civilization and later as a country free from colonization — women’s role devolved, becoming increasingly restrictive due in part to the violence. Though legislation and laws intending to protect women from violence were instituted, they regularly fell short. The culmination of societal factors, lack of legal support, and increasing media coverage showcasing violence add to an environment where this type of violence is normalized. This paper explores the different actors contributing to such normalization, specifically the Indian news media, which is accessible to many and can influence attitudes.
Manejo clínico da psicose durante a perinatalidade
Authors: Santos Daniel Lucas de Oliveira , Costa Kristen Tolomelli , Vieira Hannah Mendes , Andrade Camila Alice , Schreck Rafaela Siqueira Costa
Published: May 2024

Objetivo: Identificar as abordagens terapêuticas para o manejo da psicose em mulheres durante a gestação e o puerpério. Métodos: Revisão integrativa da literatura nas bases de dados SciELO, MedLine (via PubMed) e LILACS. Foram incluídos artigos dos últimos cinco anos, que apresentaram abordagens clínicas sobre a temática. Estudos que não especificaram a inclusão de mulheres durante a perinatalidade foram excluídos. A busca foi realizada por meio dos descritores "Psychotic Disorders", "Perinatal Care", "Pregnant Women" e "Postpartum Period". Resultados: Foram incluídos no estudo sete artigos acerca do manejo da psicose durante a perinatalidade. As evidências destacaram a importância da triagem na psicose durante o período perinatal, enfatizando a abordagem multiprofissional. O lítio é indicado como tratamento principal, com ECT para casos graves. Durante a gestação, o monitoramento sérico é crucial. Questiona-se a internação em enfermarias convencionais, priorizando o manejo centrado na paciente e no suporte às famílias. Considerações finais: Destaca-se a urgência de abordagens integradas, sensíveis e preventivas para assegurar o bem-estar psicológico durante a gravidez e o puerpério. A escassez de informações ressalta a necessidade crucial de pesquisas para aprimorar estratégias de intervenção e suporte adequado às mulheres nesse período delicado.
Perfil epidemiológico de gestantes diabéticas e desfecho neonatal em um hospital regional do Distrito Federal entre os anos de 2021 e 2022
Authors: Batalha Mariana Nascimento , Sousa Carolina Wanis Ribeiro de
Published: May 2024

Objetivo: Descrever os aspectos epidemiológicos de gestantes diabéticas e desfecho neonatal de pacientes em seguimento ecográfico no Ambulatório de Medicina Fetal e com os partos ocorridos em um Hospital Regional do Distrito Federal, no período de 01 de janeiro de 2021 a 31 de dezembro de 2022. Métodos: Estudo epidemiológico de caráter observacional, retrospectivo sobre as gestantes com diabetes e com partos ocorridos em um Hospital Regional do Distrito Federal. Resultados: Observou-se que o tipo de diabetes mais comum diagnosticado na gestação é o gestacional, tratado inicialmente através da mudança do estilo de vida, seguido ao uso de insulina. A ultrassonografia durante a gestação demonstrou um grande número de fetos grandes para a idade gestacional e polidrâmnio devido à descompensação glicêmica. A resolução da maior parte das gestações foi por via alta e durante o termo. Conclusão: É necessário do acompanhamento multiprofissional a paciente portadoras de diabetes gestacional e o acesso ao pré-natal de alto risco, visando o controle glicêmico, diminuindo assim, o impacto gerado no binômio materno-fetal.
Eruptive Epidermal Inclusion Cysts in a Renal Transplant Patient on Tacrolimus
Authors: Burns Meredith , Ho-Pham Hoang , Kole Lauren
Published: May 2024

Epidermal inclusion cysts are common cutaneous lesions that can develop anywhere on the body. While benign, these cysts can become inflamed and symptomatic. Symptomatic epidermal inclusion cysts can be treated with intralesional steroid injections or antibiotics, but surgical excision is often necessary for definitive treatment. We present a unique case of tacrolimus-induced eruptive epidermal inclusion cysts on the head and trunk of an adult male post-renal transplantation. Physicians should be familiar with this potential adverse effect, especially due to the difficulty of obtaining definitive treatment for a multitude of epidermal inclusion cysts.
Intralesional Kenalog Injections for Recurrent Cutaneous Rosai-Dorfman Disease (RDD) in the Lower Extremity
Authors: Jiminez Victoria , Zeb Lawangeen , Graham Lauren , Gray Anna
Published: May 2024

Rosai-Dorfman disease (RDD) is a rare disorder of histiocytic origin with nodal, extranodal, and cutaneous classifications often presenting as eruptive rashes, most commonly affecting the face, trunk, and thigh. Due to its rarity, no consensus exists regarding standard of care for these lesions, as most knowledge regarding treatment is provided by case reports. To our knowledge, we report the first case of a patient with a recurrent lower extremity mass consistent with cutaneous RDD, despite surgical excision and topical steroids treatment. A 51-year-old female presented with recurrent RDD after failed treatment with clobetasol ointment and surgical excision at an outside practice. Examination revealed violaceous plaques with overlying scale, without lymphadenopathy. With the failure of the previous excision, the patient was prescribed 5 mg/ml intralesional Kenalog (ILK) injections to suppress inflammation of the lesion. She experienced improved clinical response to treatment and remission of active disease with residual post-inflammatory hyperpigmentation at 10 months after two rounds of injections, although the patient reported vast improvement at 5 months as well. Treatment of RDD is difficult due to its rarity, hindering clinical trial development. Therapeutics reported to be efficacious include topical, intralesional, and systemic steroids, retinoids, methotrexate, chemotherapy, cryotherapy, phototherapy, and radiation. Clinical management is variable and often requires multiple forms of treatment on a case-to-case basis, highlighting the need for larger clinical studies to establish a standard of care. Our case poses interest in the use of ILK for RDD and should be considered in recurrent cases after prior surgical excision.
Lymphocytoma Cutis - A Case Report
Authors: Hingtgen Grace , Mojica Rafael , Robins Douglas
Published: May 2024

Without tissue biopsy and holistic review of presentation, histology, and immunohistochemistry, lymphocytoma cutis (LC) can often be misdiagnosed as other benign conditions or malignant pathologies such as cutaneous B cell lymphoma (CBCL). A 36-year-old female presented with a two-year history of a progressive indurated, edematous plaque in the preauricular area. At presentation, the patient also had labs significant for thrombocytopenia and eosinophilia. Original treatment with topical steroids did not lead to clinical improvement of the lesions. Punch biopsy revealed reactive lymphoid hyperplasia with polyclonal lymphoid infiltrates of small lymphocytes, histiocytes, eosinophils, and plasma cells. Diagnosis of LC was made and our patient was treated with serial 5 mg intralesional triamcinolone injections. Clinical improvement was seen beginning at 2 months. Diagnosing LC can be particularly difficult as the clinical presentation is ubiquitous and can resemble several other conditions such as CBCL, cutaneous lupus erythematosus, sarcoid, or hypersensitivity reactions. Recognition of the typical histologic findings of top-heavy dermal mixed-cellular infiltrates along with polyclonal kappa and lambda hybridization on immunohistochemistry is often essential in arriving at the correct diagnosis. Following diagnosis of LC, long-term surveillance is recommended as malignant transformation is a possibility.
A Review of Therapeutic Options for Linear Porokeratosis
Authors: Verma Kritin , M. K. Shalabi Mojahed , C. Hartmann Aubrey , P. Friedmann Daniel
Published: May 2024

Linear porokeratosis (LP) is a rare and uncommon variant of porokeratosis presenting as linear annular papules or plaques along Blaschko’s lines. It may arise spontaneously, although evidence of genetic predisposition exists via point mutations in the mevalonate pathway of cholesterol biosynthesis. Malignant transformation is the most serious complication of this chronic, progressive dyskeratosis. We review the currently available treatment options for LP, including topical, systemic, laser, photodynamic, and surgical therapies.
Trend Analysis of Industry Payments to Dermatologists in the United States from 2015-2022
Authors: Hardy Nicole , Gronbeck Christian , Feng Hao
Published: May 2024

Background: Open Payments, established in 2013 to address concerns about industry-driven healthcare influence, aims to enhance transparency regarding financial relationships between industry and physicians. This study investigates trends in industry payments to dermatologists between 2015 and 2022, a topic that has not been explored since a prior characterization in 2014.
Methods: We conducted a retrospective review of United States dermatologists appearing in the Open Payments database between 2015 and 2022. A Joinpoint analysis was performed to calculate the average annual percentage change (AAPC) across study years. A sensitivity analysis excluding 2020-2021 data was conducted.
Results: This study reviewed 2,616,289 payments totaling $494,271,790 made to dermatologists during the study period. The average annual percentage change (AAPC) across these years for the number of recipient dermatologists, total value of payments, and total number of payments were 1.5%, 5.5%, and 3.9%, respectively, with confirmed positive growth when excluding data from 2020-2021.
Conclusions: Payments per dermatologist have increased over the years, even when adjusting for inflation, but this growth is likely attributed to the overall expansion of the specialty. Most individual payments to dermatologists were less than $50. However, a substantial proportion of dermatologists (60%) received total payments exceeding $1000 during the study period. These findings suggest a longitudinal nature of industry-dermatologist relationships and emphasize the financial significance of payments over time. Notably, the impact of physician-industry relationships on patient care in dermatology remains debated but may influence medical decision-making and engender patient distrust.
Real-World Performance of a Noninvasive Cutaneous Melanoma Rule-Out Test: A Multicenter U.S. Registry Study
Authors: Kaufmann Mark , Skelsey Maral , Ferris Laura , Walker Michael , Rigby Andrew , Jansen Burkhard , Clarke Loren
Published: May 2024

Introduction: Non-invasive adjuncts to visual assessment of pigmented lesions may reduce biopsies of benign lesions without compromising melanoma detection. A non-invasive genomic melanoma rule-out assay analyzes RNA extracted from stratum corneum cells for PRAME and LINC00518, two genes commonly expressed in melanomas but less often in benign lesions. This study sought to characterize performance of this test in a large patient cohort tested in the real-world clinical setting.
Methods: The test was applied to suspicious pigmented skin lesions at 63 U.S. dermatology and primary care practices. Test results (positive / negative) were compared to pathology diagnoses (melanoma / not melanoma) for lesions that were biopsied and to follow-up visual examination for those that were monitored.
Results: Of 19,653 total lesions evaluated, 17,858 (90.87%) tested negative. Biopsy results and / or follow-up examinations were available for 5,096 lesions, with median and mean follow-up duration of 352 and 341 days, respectively. For melanoma, sensitivity was 95.8% and specificity was 69.4%. Positive predictive value (PPV) was 13.4%, and NPV was 99.7%. For melanoma and ‘borderline’ lesions combined, sensitivity was 94.2%, specificity was 71.2%, PPV was 20.8%, and NPV was 99.3%.
Conclusion: The results suggest this noninvasive test can facilitate distinction of melanoma from its benign simulators, increasing the proportion of pigmented lesions that can be safely managed with surveillance rather than biopsy and/or excision.
Unusual Presentation of Marginal Zone Lymphoma
Authors: Rau Akash , Opalikhin Anne , Kreuser Kaitlin , Ashack Richard , Ashack Kurt
Published: May 2024

Primary cutaneous B-cell lymphomas (pcBCLs) are non-Hodgkin lymphomas that present with exclusive cutaneous disease at the time of diagnosis. The lesions may be indolent, subtle, or waxing and waning, making the diagnosis challenging. The ear is an uncommon location, and its frequency of involvement remains unknown. A retrospective analysis of a single patient with primary cutaneous marginal zone lymphoma of the ear. The patient was a 44-year-old male who presented with erythematous tender nodules on the left superior posterior helix. Shave biopsy revealed mixed dermal lymphoid infiltrate with eosinophils and telangiectasias. The patient was diagnosed with angiolymphoid hyperplasia with eosinophilia. Multiple treatment regiments were trialed but failed due to lack of therapeutic response, relapse, and clinical progression. The patient ultimately underwent Mohs surgery with biopsy findings that demonstrated CD-20 positive cells. Evaluation with B-cell histopathology and gene rearrangement studies confirmed the diagnosis of marginal zone lymphoma. This case report shows a unique presentation of marginal zone lymphoma of the ear, initially diagnosed as angiolymphoid hyperplasia with eosinophilia. Our findings demonstrate a relatively rare presentation for this disease and highlight the challenges in diagnosing primary cutaneous marginal zone lymphoma.
Website Localization Strategies to Promote Global E-Commerce: The Moderating Role of Individualism and Collectivism
Authors: Wu Tailai , Peng Chih-Hung , Sia Choon  Ling , Lu Yaobin
Published: May 2024

Website localization plays an important role in guiding firms on how to customize websites across countries in which they have a local presence. However, few studies on website localization have systematically examined this topic from a theoretically grounded perspective. Drawing upon the theoretically driven consumer-company identification perspective, we propose that three website localization strategies (web similarity strategy, web distinctiveness strategy, and web prestige strategy) have positive effects on local users’ perceived website localization, which, in turn, is related to local users’ website loyalty. We further investigate the effects of these website localization strategies in a cross-cultural setting, focusing on the individualism-collectivism dimension of culture. Based on our online experiments in both the United States and China, we find that these website localization strategies have significant impacts on consumers’ perceived website localization, which is related to consumers’ website loyalty. We also find that web distinctiveness and web prestige strategies are more effective for people from collectivistic societies than for those from individualistic societies, whereas web similarity strategies do not differ across societal types. These findings highlight the importance of website localization strategies for customizing websites for global e-commerce.
Synergistic Quorum quenching activity of Cinnamaldehyde against biofilm forming Pseudomonas aeruginosa
Authors: Subathra Lavan , Varsha M. , Visali Kannan , Rubavathi Anandan , Murugan Athiappan
Published: May 2024

Quorum sensing is an essential mechanism for the pathogenesis of Pseudomonas aeruginosa, which causes opportunistic infections in humans. Quorum sensing inhibition has been considered a unique strategy to treat opportunistic infections and prevent an early event of infection without killing bacterial cells. The present study has demonstrated that cinnamaldehyde is able to inhibit biofilm formation by interfering with the quorum sensing activity of P. aeruginosa and is also able to disperse biofilms if they have already formed. It was also proven that synergistic action between 2.5 μM of cinnamaldehyde and 1 μM of cephalexin was effective in controlling biofilm formation. Cephalexin combined with cinnamaldehyde repressed the virulence factors associated with biofilms in Pseudomonas aeruginosa, such as Quorum sensing mediated motility, rhamnolipid, pyocyanin, elastase and rhamnolipid activities. A combination of cinnamaldehyde and cephalexin showed better biofilm inhibition (52.80%) than individual treatments and there was a reduction in the biofilm thickness and surface coverage among P. aeruginosa strains treated with cinnamaldehyde plus cephalexin. Further, it was also reported that the N-Hexanoylhomoserine lactone concentration was lower in P. aeruginosa strains treated with cinnamaldehyde plus cephalexin, while the control set-up showed a high amount of N-Hexanoylhomoserine lactone concentration. However, cinnamaldehyde with amoxycillin, oxacillin, or streptomycin showed a comparatively weaker quorum quenching effect when tested using checkerboard assays. Combination of CAD with CEPH can be a better alternative to treat P. aeruginosa infection.
Microbial Ecology of Scardovia wiggsiae and other oral microbiota in Indian children
Authors: Prathima Anusha C. , Jayakumar Karthika , Shanmugam Priyadarshini , Muthu Gopal
Published: May 2024

Early childhood caries (ECC) has become a significant health problem especially in children bellow 5 years. It has been on the ascending prevalence in many countries. The novel cariogenic bacteria Scardovia wiggsiae were identified to be significantly associated with severe-early childhood caries in the presence as well as in the absence of Streptococcus mutans. The goal of this current study was to analyse the role of Scardovia wiggsiae and other cariogenic microorganisms like Selenomonas noxia, Streptococcus mutens, Fusobacterium nucleatum and Veillonella parvula in Indian children with and without ECC. Children below 72 months were enrolled in the study and are divided into two groups of 50 each. One group consists of 50 children with ECC and other 50 without ECC. The presence of S. wiggsiae, Selenomonas noxia, Streptococcus mutens, Fusobacterium nucleatum and Veillonella parvula was examined by using 16S rRNA-based Real time PCR technique in saliva samples. The prevalence of S. wiggsiae is abundantly seen in children with ECC compared to children without ECC. Children with ECC have significantly higher prevalence (P<0.05) of S. wiggsiae, S. noxia, S. mutans, and F. nucleatum. In this study, higher and equal association rate is observed between S. wiggsiae and S. noxia, and S. wiggsiae and F. nucleatum in children with ECC. The study have demonstrated that not only a single cariogenic bacteria is responsible for ECC, but the population of oral microbiota may support for the development and progression of ECC.
Development of QSAR Models on the Fouling-Release Performance of Silicone Oil-modified Siloxane Polyurethane Coatings
Authors: Khanam Achiya , Casanola-Martin Gerardo , Daghighi Amirreza , Webster Dean , Rasulev Bakhtiyor
Published: May 2024

Polymer coatings with a fouling release activity is an effective method to prevent marine biological fouling caused by large number of marine organisms (over 4000) and ensure stability and safety of marine facilities. In this study, a novel cheminformatics-based approach was employed to investigate the fouling-release performance of siloxane-PU coating system. The structure-fouling release activity relationship was modeled for a set of 18 siloxane PU coatings by incorporation phenylmethyl silicones oils (PMM-1025, PMM-1043, PMM-5021, PMM-6025, PMM-0021, PMM-0025 of 1, 2 and 5 wt%). A specific structural descriptors encoding approach was applied for these systems, based on a mixture-based encoding, to feed the complex polymeric systems in machine learning algorithms. Several predictive quantitative structure-fouling release relationships models were developed using machine learning techniques, from multiple linear regression to nonlinear random forest methods, followed by scoring them based on high performance accuracy and validation with rigorous internal fit R2 train values between 0.73 to 0.95 and external predictivity R2ext between 0.68 to 0.88. Random Forest method was the best nonlinear one for predicting diatom removal activity. This work indicates that both linear and nonlinear machine learning-based modeling can be beneficial to predict fouling release properties of polymer coatings with an effective fouling release performance.
Switching to the non-PFAS-containing fluorosulfate leaving group, together with a Pd oxidative addition complex: rapid aminations of functionalized aromatics in water
Authors: Iyer Karthik , Dismuke Rodriguez Kylee , Lammert Robert , Yirak Jordan , Saunders John , Kavthe Rahul , Aue Donald , Lipshutz Bruce
Published: May 2024

Aryl fluorosulfates of varying complexities have been used in amination reactions in water using a new Pd oxidative addition complex (OAC) developed specifically to match the needs of the fine chemicals industry, not only in terms of functional group tolerance but also reflecting time considerations associated with these important C–N couplings. Also especially noteworthy is that they replace both PFAS-related triflates and nonaflates, which are today out of favor due to recent government regulations. The new complex based on the BippyPhos ligand is used at low loadings and under aqueous micellar conditions. Moreover, it is easily prepared and stable to long-term storage. DFT calculations on the OAC precatalyst compare well with the X-ray structure of the crystals with -complexation to the aromatic system of the ligand and also confirm the NMR data showing a mixture of conformers in solution that differ from the X-ray structure in rotation of the phenyl and t-butyl ligand substituents. An extensive variety of coupling partners, including pharmaceutically relevant APIs, readily participate under mild and environmentally responsible reaction conditions
Separating Hofmeister Trends in the Stern and Diffuse Layer Structures at a Charged Aqueous Interface
Authors: Tetteh Nathaniel , Parshotam Shyam , Gibbs Julianne M.
Published: May 2024

Understanding the role of pH and ions on the electrical double layer (EDL) structure of charged mineral oxide/aqueous interfaces remains crucial in modeling various environmental and industrial processes. Yet the simultaneous contribution of pH and specific ion effects (SIEs) on the different layers of the EDL remains unknown. Here, we utilize zeta potential (ζ) measurements, vibrational sum frequency generation (vSFG), and the maximum entropy method (MEM) to ascertain the detailed structure of water in the Stern and diffuse regions of the EDL at the silica/water interface under varying pH conditions for different alkali chlorides. Both at pH 2, when the surface is nearly neutral, and at pH 12, when the surface is highly charged, we observe that the Li+ and Na+ disrupt existing water structures within the Stern layer while Cs+ enhances them. Moreover, the SIE trends for the diffuse and Stern layers are opposite with respect to one another at pH 2 (in the amount of ordered water) and at pH 12 (in amount of net oriented water). Finally, we observe pH-dependent SIE in ζ, which results in Cs+ exhibiting the least ordered diffuse layer at low pH and the most at high pH. These results indicate that SIEs play critical yet separable roles in governing both electrostatic and water structuring capabilities in the EDL at charged surfaces.
Describing Chiral Ligands in Palladium-catalyzed Decarboxylative Asymmetric Allylic Allylation: A Critical Comparison of Three Machine Learning Approaches
Authors: Galvin Declan , Aguilar Bejarano Eduardo Alberto , Rogers David M. , Woodward Simon , Özcan Ender , Guiry Patrick J. , Figueredo Grazziela
Published: May 2024

Despite its current popularity, machine learning (ML) applied to asymmetric catalysis remains underexplored. Present strategies include direct use of existing descriptors (e.g. those originally formulated for medicinal chemistry), the development of new bespoke steric and electronic descriptors, or the use of molecular graphs. This method diversity, in the absence of user guidelines, makes selecting an optimal ML algorithm unclear. The fact that asymmetric catalysis data sets are frequently small also make interpretable ML of chiral ligand understanding difficult to realize. Herein, we present an exhaustive evaluation of reaction representations in combination with different machine learning algorithms (including linear regression, random forests, gradient boosting, and graph neural networks) using a realistic-size database compromising 103 palladium- catalyzed decarboxylative asymmetric allylic alkylation (DAAA). This database consists of the combination of three different Trost-type ligands with 54 different substrates. It is concluded that our new bespoke steric and electronic descriptors offer the best performance, while overcoming the problem of interpretability of using existing topo-electronic descriptors, and the problem of data requirements of Graph Neural Networks.
Mining Medicinally Relevant Bioreduction Substrates Inspired by Ligand-Based Drug Design
Authors: Rago Alexander , Zoi Ioanna , Gartman Jackson , McDaniel Kelly , Jana Navendu , Liu Dachun , Bai Wen-Ju
Published: May 2024

Exploring the scope of biocatalytic transformations in the absence of enzyme structures without extensive experimentation is a challenging task. To expand the limited substrate capacity of carrot-mediated bioreduction and hunt for new medicinally relevant ketones with minimum cost of labor and time, we deployed a practical method inspired by ligand-based drug design. Through analyzing collected literature data and building pharmacophore and reactivity prediction models, we screened a self-built virtual library of >8000 ketones bearing the most frequently used N, O, S-heterocycles and functional groups in drug discovery. Representative examples were validated, expanding the bioreduction substrate scope. The public availability of our models alongside the straightforward screening workflow make it time-, labor-, and cost-saving to evaluate unknown bioreduction substrates for medicinal chemistry applications, especially for a large set of structurally differentiated ketones. Our studies also showcase the novelty of utilizing medicinal chemistry principles to solve a general biocatalysis problem.
Improved synthesis of the unnatural base NaM, and evaluation of its orthogonality in in vitro transcription and translation
Authors: Le Anthony , Hartman Matthew
Published: May 2024

Unnatural Base Pairs (UBP) promise to diversify cellular function through expansion of the genetic code. Some of the most successful UBPs are the hydrophobic base pairs 5SICS:NaM and TPT3:NaM developed by Romesberg. Much of the research on these UBPs has emphasized strategies to enable their efficient replication, transcription and translation in living organisms. These experiments have achieved spectacular success in certain cases; however, the complexity of working in vivo places strong constraints on the types of experiments that can be done to optimize and improve the system. Testing UBPs using in vitro, on the other hand, offers advantages including minimization of scale, the ability to precisely control the concentration of reagents, and simpler purification of products. Here we investigate the orthogonality of NaM-containing base pairs in transcription and translation, looking at background readthrough of NaM codons by the native machinery. We also describe an improved synthesis of NaM UBP triphosphate and a new assays for testing the purity of NaM containing RNAs.
THE ROLE of WORKERS’ PARTICIPATION on WORKERS’ WELLBEING, WORKPLACE WELLNESS and SAFETY at SELECTED RESEARCH INSTITUTES in Ilorin, Kwara State, Nigeria
Authors:   Department of Human Kinetics and Health Education, Tai Solarin University of Education, Ijebu-Ode, Ogun State, Nigeria, BELLO Moshood Olalekan , ADAGBOR Pedro Uwadum ,   Department of Human Kinetics and Health Education, Tai Solarin University of Education, Ijebu-Ode, Ogun State, Nigeria, NWANGWU Adaobi ,   University of Wolverhampton, Wulfruna St, Wolverhampton, UK, UKPERE Wilfred Isioma ,   University of Johannesburg
Published: May 2024

Severe consequences of the Covid-19 pandemic reinforced the importance of occupational health and safety. Associated economic disruptions and the entrenchment of institutional dynamics that are at variance with workers’ interests have placed additional pressures on workplace wellness and safety measures. The connection between organisational productivity and worker safety and wellness requires worker participation to institutionalise wellness and safety measures at work. This paper examines the role of workers’ participation in shaping the wellbeing of workers around workplace safety and wellness at two research institutes in Ilorin, Kwara State, Nigeria. A case study design was employed as a research strategy for the study. The justification to adopt this design hinges on its capacity to enhance empirical enquiry on workers’ participation in decisions that affect them as far as workplace wellness and safety are concerned at the case institutes. The samples were selected through a combination of cluster and random sampling methods. A total of 302 questionnaires were distributed at the two research institutions; however, only 265 were returned and found to be appropriate to use in the study. Despite the significance of workplace health and safety awareness, training, education, and regulations, the study showed that employees have not been given the attention that they deserve to shape the programme.
Microfoundations of Organizational Growth: Consequences for Entry Strategies and Financing of New Ventures
Authors:   NHH Norwegian School of Economics Helleveien, Obu Osiebuni Collins , Ukpere Wilfred ,   University of Johannesburg
Published: May 2024

An enormous number of firms fail to deliver economically profitable growth in output even though they may have strong managerial teams and adequate capital. In this paper, we provide new empirical evidence to demonstrate a few fundamental factors that can account for the ability of a firm to achieve economically sustainable scaling. In a bid to achieve that, we surveyed and discussed the prevailing theories that have established various grounds for organizational growth. On the basis of these theories, we hypothesized about the likely microfoundations for organizational growth. We went further to test these hypotheses using empirical data for all publicly-listed Nordic firms over a lengthy span of time, specifically ranging from 1990 to 2020. To implement the test, we established an econometric model, which is predicated on variables that we argued are capable of serving as a proxy for the microfoundations identified. It is our submission that effective and sustainable attainment of growth in output requires a new entrant to develop strategies that are centered on innovative products, as well as target highly concentrated industries, which are characterized by large markets, while financing such economic activities using equity capital as against debt capital.
Competitive Intelligence and Academic Entrepreneurship as Innovative Vectors of a Resilient, Business-Oriented Education
Authors:   The Bucharest University of Economic Studies, Dinu Daniel Gabriel , Stoian Karadeli Andreea ,   The University of Texas Rio Grande Valley, Mihoreanu Larisa ,   The Bucharest University of Economic Studies, Pașcu Gabără Elena Iuliana ,   The Bucharest University of Economic Studies, Păduraru Mihail ,   The Bucharest University of Economic Studies
Published: May 2024

Purpose – The present paper substantiates that the concepts of competitive intelligence and academic entrepreneurship are genuinely connected to the modern society and, through their perpetual and versatile evolution, have an important role in moving the development on the right way. Design/methodology/approach – Their evolutive is completed by a comparative analysis as appropriate method to point out similarities and differences and identify the way their application may serve innovation as a tool for those activating in the related domains of education, within our highly dynamic world. Findings – The development of the concepts is meant to link and accelerate the technological and operational innovation to a highly competitive academic environment, business-oriented, as a contribution to its wide potential for profit. Originality/value – The correlation between the two concepts provides an innovative tool able to serve as a platform helping the competitive intelligence, as design and functions, for any academic entrepreneurship business-oriented.
The Role Of Institutional Quality, Foreign Direct Investment, And Country Size On Trade Openness In The ASEAN-6 Region
Authors:   Department of Economic and Development , Faculty of Economics, Sriwijaya University, indonesia, Azwardi Wahyu Aji Wijaya , Bashir Abdul
Published: May 2024

The current development of globalization has led to a very fundamental transformation in the economic system. the phenomenon of globalization cannot be avoided by any country, moreover countries that previously isolated it from the outside world cannot be avoided either. Therefore any country will still be affected by globalization, so that it will create international trade that is increasingly spreading from every country. This study aims to analyze the role of institutional quality through government effectiveness and regulatory quality, foreign direct investment, and country size on trade openness in the ASEAN-6 region during the 2002-2021 period using panel data analysis techniques. in using the panel data technique based on the best testing through the Chow test and the Hausman test that the best model used in this study is the Fixed Effect Model (FEM) which shows the variables of government effectiveness and investment directly have a positive and significant effect on trade openness. while the quality of regulations and country size have a negative and significant effect on trade openness in the Asean Region.
The impact of leadership styles on the social responsibility of industrial companies in Romania
Authors:   The Academy of Economic Studies, Bucharest, Romania, Mohammed Raghad , Costea Carmen Eugenia ,   The Academy of Economic Studies, Bucharest, Romania
Published: May 2024

This study aimed to examine the impact of leadership styles on the social responsibility of industrial companies in Romani. To achieve this objectives the study used descriptive analytical approach through develop questionnaire to collect data from the sample which consists (357) managers who work in industrial companies in Romani. A total of (340) suitable questionnaire were retrieved for statistical analysis, the study used Statistical Package for the Social Sciences software (SPSS. 25) to analyses the collecting data and test the hypothesis. The study results showed that, there is impact of Authoritative leadership on social responsibility of industrial companies in Romania, there is impact of Democratic leadership on social responsibility of industrial companies in Romania, there is impact of Facilitative leadership on social responsibility of industrial companies in Romania, and there is no impact of Situational leadership on social responsibility of industrial companies in Romania. In light of these findings the study recommended the need to pay attention to the quality of leaders who are appointed in industrial companies in Romania due to the clear impact of the quality of leadership at the level of social responsibility practices of companies.
Inflammatory risk contributes to post-COVID endothelial dysfunction through anti-ACKR1 autoantibody
Authors: Lee Ee-Soo , Nguyen Nhi , Young Barnaby E , Wee Hannah , Wazny Vanessa , Lee Khang Leng , Tay Kai Yi , Goh Liuh Ling , Chioh Florence WJ , Law Michelle CY , Lee I. Russel , Ang Lay Teng , Loh Kyle M , Chan Mark Y , Fan Bingwen E , Dalan Rinkoo , Lye David C , Renia Laurent , Cheung Christine
Published: May 2024

Subclinical vascular impairment can be exacerbated in individuals who experience sustained inflammation after COVID-19 infection. Our study explores the prevalence and impact of autoantibodies on vascular dysfunction in healthy COVID-19 survivors, an area that remains inadequately investigated. Focusing on autoantibodies against the atypical chemokine receptor 1 (ACKR1), COVID-19 survivors demonstrated significantly elevated anti-ACKR1 autoantibodies, correlating with systemic cytokines, circulating damaged endothelial cells, and endothelial dysfunction. An independent cohort linked these autoantibodies to increased vascular disease outcomes during a median 6.7-yr follow-up. We analyzed a single-cell transcriptome atlas of endothelial cells from diverse mouse tissues, identifying enrichedAckr1expressions in venous regions of the brain and soleus muscle vasculatures, which holds intriguing implications for tissue-specific venous thromboembolism manifestations reported in COVID-19. Functionally, purified immunoglobulin G (IgG) extracted from patient plasma did not trigger cell apoptosis or increase barrier permeability in human vein endothelial cells. Instead, plasma IgG enhanced antibody-dependent cellular cytotoxicity mediated by patient PBMCs, a phenomenon alleviated by blocking peptide or liposome ACKR1 recombinant protein. The blocking peptide uncovered that purified IgG from COVID-19 survivors possessed potential epitopes in the N-terminal extracellular domain of ACKR1, which effectively averted antibody-dependent cellular cytotoxicity. Our findings offer insights into therapeutic development to mitigate autoantibody reactivity in blood vessels in chronic inflammation.
The New Normal
Authors: White Jeffery S. , Martinez Michael
Published: May 2024

Over the past two years, sport organizations worldwide have had to adapt traditional operating procedures regarding employee health and well-being as a response to the COVID-19 pandemic. Among these has been the implementation of remote work as an integral part of organizational structure. Through a review of the general literature regarding remote work, this paper presents an argument for the adoption of remote work as part of the standard operating practices of intercollegiate athletic departments. Specifically, organizational control theory provides a lens through which college athletic organizations can implement remote work and maintain a level of organizational effectiveness by utilizing the management of communication and trust. By extending scholarship on organizational control theory within sport management, the utilization of the organizational controls will allow athletic department leadership to modernize their departments while gaining competitive advantage.
Mutu Pelayanan Kesehatan Ibu dan Bayi Berdasarkan Data Statistik Indikator Kebidanan
Authors: Rosita Riska , Nur’aini Djien
Published: May 2024

Perhitungan statistik sangat diperlukan untuk menentukan produktivitas semua jenis pelayanan di rumah sakit, salah satunya pada kegiatan pelayanan kebidanan. Sumah sakit memberikan pelayanan kebidanan, termasuk Rumah Sakit Hermina Solo. Berdasarkan survey pendahuluan diketahui bahwa jumlah kunjungan pasien kebidanan pada tribulan IV tahun 2018 mengalami penurunan. Rumah Sakit Hermina Solo belum pernah membuat laporan statistik indikator kebidanan, sehingga kesulitan untuk menganalisis dan mengevaluasi pelayanan kebidanan yang sudah ada saat ini. Penelitian ini bertujuan untuk mengetahui mutu pelayanan kesehatan ibu dan bayi berdasarkan data statistik indikator kebidanan di Rumah Sakit Hermina Solo. Penelitian ini bersifat deskriptif dengan menggunakan pendekatan Cross Sectional. Populasi dalam penelitian ini berupa data bulanan kamar bersalin tahun 2018 di Rumah Sakit Hermina Solo dengan total 1.943 kasus. Hasil penelitian ini menunjukkan bahwa (1) rasio persalinan normal terhadap total persalinan per tribulan paling sedikit 1:2, (2) rasio persalinan dengan komplikasi terhadap total persalinan per tribulan paling sedikit 1:8, (3) rasio Sectio Cesaria terhadap total persalinan per tribulan 1:1, (4) rasio Abortus terhadap total persalinan per tribulan 1:19, (5) rasio perdarahan sebelum persalinan terhadap total persalinan per tribulan 1:37, (6) rasio perdarahan sesudah persalinan terhadap total persalinan per tribulan 1:25, dan (7) rasio Pre eklampsia terhadap total persalinan 1:18. Kesimpulan, mutu pelayanan kesehatan ibu dan anak di Rumah Sakit Hermina Solo tahun 2018 dinilai sudah baik. Adapun kasus patologi yang masih sering terjadi bukan karena rendahnya mutu rumah sakit melainkan dipengaruhi oleh karakteristik ibu dan janin.Sebaiknya pihak manajemen rumah sakit membuat laporan grafik analisis indikator kebidanan setiap periode secara teratur agar bisa mengevaluasi dan meningkatkan mutu pelayanan kesehatan ibu dan anak.
Analisis Penggunaan Media Sosial Terhadap Kejadian Insomnia Pada Mahasiswa
Authors: Andiarna Funsu , Prasetyaning Widayanti Linda , Hidayati Irul , Agustina Eva
Published: May 2024

Internet merupakan hasil kemajuan teknologi yang semakin pesat sudah menjadi kebutuhan setiap orang. Internet memudahkan setiap orang mengakses semua informasi yang dibutuhkan dengan lebih cepat, efektif dan efisien, mempermudah komunikasi tanpa terbatas waktu dan tempat. Media sosial merupakan salah satu media yang sekarang ini menjadi kebutuhan bagi setiap orang. Penggunaan media sosial memiliki dampak positif dan negatif. Dampak positif tentunya dapat dijadikan sebagai sarana menambah wawasan, meningkatkan keterampilan serta menumbuhkan kepedulian terhadap sesama. Penelitian ini bertujuan untuk menganalisis penggunaan media sosial terhadap kejadian insomnia pada mahasiswa. Jenis penelitian ini merupakan observasional analitik dengan pendekatan cross sectional. Penelitian ini dilakukan pada mahasiswa UIN Sunan Ampel Surabaya dengan jumlah sampel sebanyak 194 responden dengan teknik simple random sampling. Analisis data dalam penelitian ini menggunakan uji korelasi Spearman rank. Hasil penelitian menunjukkan terdapat hubungan antara penggunaan media sosial dengan kejadian insomnia (ρ=0,028) dengan kuat hubungan sangat lemah (R=0,158)