bluuebunny/crossref_metadata_2025 huggingface dataset:
The effects of workplace friendship network centrality on deep acting
Authors: Kim Na Yoon , Oh Hongseok
Published: June 2023

We integrated social network theory with conservation of resource theory to predict that workplace friendship network centrality provides service employees with critical psychological resources that foster deep acting: positive affect and positive self-perception. In Study 1, we conducted a survey (N = 105) in a Korean banking firm, revealing that these resources mediate the relationship between workplace friendship network centrality and deep acting. Studies 2 and 3, both experimental studies, investigated the hypothesized causal relationships. In Study 2 (N = 151), we found that workplace friendship network centrality increases the intention toward deep acting. Further, Study 3 (N = 140) confirmed the direct effects of friendship network centrality on positive affect and self-perception. By providing insights into the structural antecedents of emotional labor, we inform managers in service organizations of the value of creating avenues for their employees to form and maintain friendships within the organization.
Influence of the sociocultural perspective on the sensory perception of wine consumers in Mexico and Spain
Authors: Sánchez Elena , Oliveras Ingrid , Romero del Castillo Maria Roser , Salazar Angeles
Published: June 2023

The increasing globalization of companies and markets, including the wine market, makes this study important as a cultural comparison between the sensory perception of wine in Mexico and Spain. Eighty consumers were selected with different consumption habits, and hedonic (Acceptance and Simple Preference) and descriptive (Word Association Task and the Check-All-That-Apply (CATA) method) sensory tests were performed. The results revealed that there were differences in the conceptualization of wine in the Word Association Task. Both populations preferred wines of Spanish origin over those of Mexican origin, especially in the case of red wine. Finally, the results of the CATA method showed that the attributes that discriminate the two types of wine are due more to the country origin of the tasters than to the samples. Spanish consumers used cultural and tradition descriptors and were stricter when it came to sensory evaluation. Moreover, Spanish participants demonstrated more ability to differentiating all wines in terms of visual, olfactory and taste aspects.
Neural basis of the attention bias during addiction stroop task in methamphetamine-dependent patients with and without a history of psychosis: an ERP study
Authors: Huang Gengdi , Han Chuanliang , Yang Jihui , Ye Caihong , Javed Iqbal , Liu Fen , Kong Zhi , Li Ying , Zhu Yingmei , Yi Guangyong , Ju Chuanjia , Jia Xiaojian , Yang Mei
Published: June 2023

Background

Attentional bias plays an important role in sustaining various types of drug addiction. No prior studies examined methamphetamine (MA)-associated psychosis (MAP) relationships between ERP time course and performance on an addiction Stroop task in MA abusers. The aim of the present study was to determine whether MA abusers with (MAP+) or without (MAP-) psychosis exhibit alterations of the ERP during the addiction Stroop task.

Methods

Thirty-one healthy controls (CTRL), 14 MAP-, and 24 MAP+ participants were recruited and completed the addiction Stroop task during EEG recording using 32 electrodes. Group variations were compared on measures of behavioral task performance and event-related potentials (ERP) of performance monitoring (N200, P300, N450). The Barratt impulsiveness scores were analyzed to investigate correlations with ERP changes.

Results

MA-related word stimulus elicited a more negative N200 amplitude over left-anterior electrodes in MAP- abusers; furthermore, a positive association between the N200 amplitude and Barratt attentional scores and non-planning scores was observed, while no such differences were found in MAP+ abusers. There were no significant differences in reaction time (RT) and error rate between each group.

Conclusion

This is the first study to examine psychosis relationships between ERP time course and performance on an addiction Stroop task in MA abusers with or without psychosis. These findings support the association between attentional bias measured by the MA addiction Stroop task and N200 component as well as indicate the possibility of using this cognitive task in combination with ERP technology to detect psychosis factors among abstinent MA abusers.
Music performance anxiety: the role of early parenting experiences and cognitive schemas
Authors: Kirsner Jennifer , Wilson Sarah J. , Osborne Margaret S.
Published: June 2023

Music Performance Anxiety (MPA) is a common challenge for classical musicians, however its etiology has received minimal research, particularly in regards to caregiver experiences during childhood and adolescence. The aim of this research was to explore the impact of childhood experiences with parents along with patterns of dysfunctional cognitive schemas that develop through childhood ('Early Maladaptive Schemas'; EMSs) on the manifestation and severity of MPA in adulthood. Study 1 employed 100 adult professional, amateur, and tertiary student classical musicians from across Australia. Participants completed the Young Schema Questionnaire (YSQ) and the Kenny Music Performance Anxiety Inventory (K-MPAI). Study 2 included eight participants from Study 1, five of whom scored 1.5 standard deviations or more above the mean K-MPAI score and three of whom scored 1.5 standard deviations or more below the mean K-MPAI score. Participants were interviewed about experiences of parenting during childhood and adolescence, along with their experiences of MPA and musical training. Interpretative phenomenological analysis was used to explore themes in the interview data. Study 1 factor analysis revealed four higher-order EMS factors, F(4, 95) = 13.74, p < 0.001, one of which was a significant predictor of MPA, t(99) = 3.06, p = 0.003. This factor comprised themes of failure, catastrophising, and incompetence/dependence. Study 2 qualitative analysis revealed various key parenting themes experienced in childhood that differentiated low- and high-MPA scorers in adulthood. Findings from both studies are discussed in light of clinical applications and interventions, and implications for both parents and music educators.
Athletes’ self-compassion and emotional resilience to failure: the mediating role of vagal reactivity
Authors: Zhang Nan , Huang Jiasheng , Yao Jiaxin
Published: June 2023

Whether athletes’ self-compassion predicts their emotional resilience to failure has yet to be empirically tested. Moreover, as an important physiological process of stress regulation, vagal reactivity is a plausible physiological mechanism for this relationship. Through a laboratory-based observational study of 90 college athletes, this research explores the influence of athletes’ trait self-compassion on their emotional resilience when recalling failure, and examines whether vagal reactivity plays a mediating role. The results show that self-compassion did not significantly predict athletes’ positive emotions but did significantly predict better recovery from negative emotions after recalling failure events. Furthermore, vagal reactivity was a significant mediator between self-compassion and recovery from negative emotions.
The mediating effect of math self-efficacy on the relationship between parenting style and math anxiety
Authors: Wang Chao , Li Xian , Wang Hui-jiao
Published: June 2023

The present study aims to investigate the associations among math self-efficacy, parenting style, and math anxiety in primary school children. The sample comprised 400 participants, aged between 10 and 11 years old, from an elementary school in China. Participants completed three self-reported questionnaires on math anxiety, parenting styles and math self-efficacy. The results revealed that rejection was strongly and positively correlated with math anxiety, while emotional warmth was negatively related to math anxiety. Interestingly, math anxiety was found to be related to rejection, with math self-efficacy playing a mediating role in this relationship. Conversely, math self-efficacy played a mediating role in the relationship between parenting styles and math anxiety, while over protection exhibited no significant correlation with math anxiety. The study also showed that gender differences existed in the level of math anxiety and math self-efficacy, with boys exhibiting lower math anxiety and higher math self-efficacy than girls. These results provide important insights into the development and treatment of math anxiety in primary school children. Specifically, parents and educators should focus on enhancing children’s math self-efficacy beliefs, while adopting a parenting style characterized by emotional warmth and low levels of rejection.
Predictors of prospective suicide attempts in a group at risk of personality disorder following self-poisoning
Authors: Cailhol Lionel , Marcoux Mariève , Mathur Anjali , Yrondi Antoine , Birmes Philippe
Published: June 2023

Background

Patients with personality disorder (PD) are at risk for suicidal behavior and are frequently admitted for this reason to emergency departments. In this context, researchers have tried to identify predictors of their suicidal acts, however, the studies have been mostly retrospective, and uncertainty remains. To prospectively explore factors associated with suicide attempts (SA) in individuals screened for PD from the ecological context of emergencies.

Methods

Patients were recruited from two emergency departments after a self-poisoning episode (n = 310). PDQ-4+ (risk of PD), TAS-20 (alexithymia), SIS (suicidal intent), H (hopelessness), BDI-13 (depression), AUDIT (alcohol consumption), and MINI (comorbidity) questionnaires were completed. SA over the subsequent two years were identified by mailed questionnaires and hospitals’ active files. Logistic regression analyses were performed.

Results

Having a previous suicidal attempt was linked to a 2.7 times higher chance of recurrence after 6 months, whereas the TAS-20 showed a 1.1 times higher risk at 18 months (OR = 1.1) and the BDI at 24 months (OR = 1.2). Each one-unit increment in TAS-20 and BDI-13 scores increased the risk of SA by 9.8 and 20.4% at 18 and 24 months, respectively.

Conclusion

Some clinical features, such as alcohol dependence, suicide intent, and hopelessness, may not be reliable predictors of SA among PD patients. However, in the short term, previous SA and, in the long term, depression and alexithymia may be the most robust clinical predictors to consider in our sample of patients with self-poisoning SA.

Clinical trial registration: [ClinicalTrials.gov], NCT00641498 24/03/2008 [#2006-A00450-51].
Protocol for an observational cohort study on psychological, addictive, lifestyle behavior and highly prevalent affective disorders in primary health care adults
Authors: Méndez-López Fátima , Oliván-Blázquez Bárbara , Domínguez-García Marta , Bartolomé-Moreno Cruz , Rabanaque Isabel , Magallón-Botaya Rosa
Published: June 2023

Background

Depression and anxious symptoms are prevalent in the general population, and their onset and persistence may be linked to biological and psychosocial factors, many of which are lifestyle-related. The way we manage our care, physical and emotional health and/or discomfort is highly influenced by our own abilities, skills and attitudes despite life’s circumstances. The main aim of this protocol to analyze the relationship between psychological constructs (self-efficacy, activation, health literacy, resilience, personality traits, sense of coherence, self-esteem), and the presence of affective-emotional problems (anxiety, depression) and addictions in primary health care.

Methods

This is a protocol of a prospective longitudinal cohort study including people of 35–74 years old of Aragon primary health care centers (Spain). Three evaluations will be conducted: baseline evaluation, and follow-up assessments five and ten years after recruitment. The primary outcomes will be severity of depression, severity of anxiety, and addictive behaviors. A detailed set of secondary outcomes will be assessed across all three assessments. This will include psychosocial or personal factors on health behavior, social support, lifestyle patterns, quality of life, the use of health and social resources, and chronic comorbid pathology.

Discussion

The analysis of the impact of psychological constructs and lifestyles on the mental health of people and communities will provide evidence that will make it possible to better address and prevent these prevalent problems and address their improvement from a more global and holistic perspective. The evaluation of psychological constructs should be incorporated into health services to improve people’s ability their self-care, the level of knowledge of managing their disease and their physical, mental and social health.

Clinical trial registration

https://www.isrctn.com/, identifier ISRCTN12820058.
Effect of transcranial direct current stimulation on the functionality of 40 Hz auditory steady state response brain network: graph theory approach
Authors: Hirosawa Tetsu , Soma Daiki , Miyagishi Yoshiaki , Furutani Naoki , Yoshimura Yuko , Kameya Masafumi , Yamaguchi Yohei , Yaoi Ken , Sano Masuhiko , Kitamura Koji , Takahashi Tetsuya , Kikuchi Mitsuru
Published: June 2023

Introduction

Measuring whole-brain networks of the 40 Hz auditory steady state response (ASSR) is a promising approach to describe the after-effects of transcranial direct current stimulation (tDCS). The main objective of this study was to evaluate the effect of tDCS on the brain network of 40 Hz ASSR in healthy adult males using graph theory. The second objective was to identify a population in which tDCS effectively modulates the brain network of 40 Hz ASSR.

Methods

This study used a randomized, sham-controlled, double-blinded crossover approach. Twenty-five adult males (20–24 years old) completed two sessions at least 1 month apart. The participants underwent cathodal or sham tDCS of the dorsolateral prefrontal cortex, after which 40 Hz ASSR was measured using magnetoencephalography. After the signal sources were mapped onto the Desikan–Killiany brain atlas, the statistical relationships between localized activities were evaluated in terms of the debiased weighted phase lag index (dbWPLI). Weighted and undirected graphs were constructed for the tDCS and sham conditions based on the dbWPLI. Weighted characteristic path lengths and clustering coefficients were then measured and compared between the tDCS and sham conditions using mixed linear models.

Results

The characteristic path length was significantly lower post-tDCS simulation (p = 0.04) than after sham stimulation. This indicates that after tDCS simulation, the whole-brain networks of 40 Hz ASSR show a significant functional integration. Simple linear regression showed a higher characteristic path length at baseline, which was associated with a larger reduction in characteristic path length after tDCS. Hence, a pronounced effect of tDCS is expected for those who have a less functionally integrated network of 40 Hz ASSR.

Discussion

Given that the healthy brain is functionally integrated, we conclude that tDCS could effectively normalize less functionally integrated brain networks rather than enhance functional integration.
Cerebrospinal fluid biomarkers in psychiatric autoimmune encephalitis: a retrospective cohort study
Authors: Hansen Niels , Juhl Aaron Levin , Grenzer Insa Maria , Teegen Bianca , Wiltfang Jens , Fitzner Dirk
Published: June 2023

Background

Psychiatric autoimmune encephalitis (pAE) is a growing field of interest in diagnosis and therapy in psychiatric hospitals and institutions. This study investigates the relevant extent to which there are potential biomarkers in cerebrospinal fluid (CSF) that can differentiate against a cohort with neurodegenerative disease.

Methods

We included in this study a total of 27 patients with possible and definite psychiatric autoimmune encephalitis and compared with a cohort with CSF-based AD (n = 27) different biomarkers in CSF such as lactate, cell count, % lymphocytes, % monocytes, total protein content, albumin, immunoglobulins G (IgG), M (IgM) and A (IgA), CSF/serum albumin ratio, CSF/serum IgG ratio, CSF/serum IgA ratio, intrathecal IgG synthesis, blood–brain barrier disruption, specific antibody synthesis for measles, rubella, herpes simplex virus, varicella zoster virus, Ebstein-Barr virus and cytomegalovirus, total tau protein (t-tau), phosphorylated tau protein 181 (p-tau181), amyloid beta 42 (Aß42), amyloid beta 40 (Aß40) and the amyloid beta 42/ amyloid beta 40 (Aß42/40) ratio.

Results

The p-tau 181 was elevated above cut-off values in both possible pAE and AD. However, in definitive pAE, p-tau181 levels were not elevated. When elevated p-tau181 levels in possible AE were compared with those in AD, we found relevant differences, such as a relative increase in p-tau181 in AD patients. Elevated p-tau181 levels were detected in possible psychiatric AEs with IgLON5, glycine, recoverin, titin, and nonspecific neuropil antibodies in serum and IgLON5, titin, Yo, and nonspecific neuropil autoantibodies in CSF. In addition, we detected elevated levels of p-tau181 and IgLON5 autoantibodies in serum and CSF, and Yo autoantibodies in CSF in patients with definitive pAE. Interestingly, we observed a higher CSF/serum IgM ratio in possible and definitive pAE than in AD patients.

Conclusion

Our results suggest that neuroaxonal brain damage may occur in specific psychiatric AEs associated with IgLON5, glycine, recoverin, and titin autoantibodies. Further research should focus on the CSF/serum IgM ratio as an early marker of autoantibody production in pAE compared to AD as a potential biomarker for differential diagnosis.
Prevalence and influencing factors of suicide in first-episode and drug-naive young major depressive disorder patients with impaired fasting glucose: a cross-sectional study
Authors: Li Yifan , Liao Zhenjiang , Huang Qiuping , Wang Qianjin , Ren Honghong , Chen Xinxin , Lin Shuhong , Wang Chenhan , Tang Ying , Hao Jingyue , Wang Xuhao , Shen Hongxian , Zhang Xiangyang
Published: June 2023

Background

An association exists between major depression disorder (MDD), suicide attempts, and glucose metabolism, but suicide attempts in young MDD patients with comorbid impaired fasting glucose (IFG) have been less well studied. The purpose of this study was to examine the prevalence and risk factors for suicide attempts in young, first-episode, drug-naive (FEDN) MDD patients with comorbid IFG.

Methods

We recruited 917 young patients with FEDN MDD, 116 of whom were judged to have combined IFG because their blood glucose was >6.0. We collected anthropological and clinical data on all of them. The Hamilton Depression Scale (HAMD) score, the Hamilton Anxiety Scale (HAMA) score and the Positive and Negative Syndrome Scale (PANSS) positive subscale score were used to assess their clinical symptoms. Blood glucose, plasma thyroid function and lipid indicators were measured.

Results

The prevalence of suicide attempts in young MDD patients with IFG was 32.8% (38/116). Furthermore, among young MDD patients with comorbid IFG, suicide attempters had more severe depression and anxiety symptoms, more comorbid psychotic symptom, higher levels of antibody of thyroid stimulating hormone and thyroid peroxidases (TPOAb), and more severe lipid metabolism disorders than those without suicide attempts. In addition, HAMA scores and TPOAb were independently associated with suicide attempts in young patients with FEDN MDD.

Conclusion

Our study suggests that young MDD patients with IFG have a high rate of suicide attempts. Some clinical symptoms and thyroid function parameters may be the risk factor for suicide attempts in young MDD patients with impaired glucose metabolism.
Sleep and behavioral problems in Down syndrome: differences between school age and adolescence
Authors: Fucà Elisa , Costanzo Floriana , Celestini Laura , Galassi Paolo , Villani Alberto , Valentini Diletta , Vicari Stefano
Published: June 2023

Background

Individuals with Down syndrome (DS) are at risk of developing sleep problems. In spite of the well-established knowledge on the presence of sleep difficulties in DS individuals and the associated emotional and behavioral problems, less is known about the possible differences in the kind of associations between sleep and emotional/behavioral problems across different age ranges.

Methods

In this retrospective study, we included 289 participants with DS aged 6–18 years with the aims to explore differences in the distribution of sleep problems between specific age groups (school age vs. adolescence) and to identify specific age-based associations between sleep problems and emotional/behavioral problems.

Results

Some differences in the distribution of sleep problems have emerged between age groups. Moreover, differences in the patterns of association between emotional/behavioral difficulties and sleep problems-in particular, sleep-related breathing difficulties and parasomnias-have been observed. However, sleep-wake transition disorders and excessive daily somnolence appear to be related to emotional and behavioral problems (both internalizing and externalizing), in general, across school age and adolescence.

Discussion

These results remark the importance of appropriate neuropsychiatric and psychological evaluation taking into account the age-specific needs and features of individuals with DS.
5hmC modification regulates R-loop accumulation in response to stress
Authors: Xu Xingyun , Wang Junjie , Wang Wenjuan , Zhang Yutong , Wan Bo , Miao Zhigang , Xu Xingshun
Published: June 2023

R-loop, an RNA-DNA hybrid structure, arises as a transcriptional by-product and has been implicated in DNA damage and genomic instability when excessive R-loop is accumulated. Although previous study demonstrated that R-loop is associated with ten-eleven translocation (Tet) proteins, which oxidize 5-methylcytosine to 5-hydroxymethylcytosine (5hmC), the sixth base of DNA. However, the relationship between R-loop and DNA 5hmC modification remains unclear. In this study, we found that chronic restraint stress increased R-loop accumulation and decreased 5hmC modification in the prefrontal cortex (PFC) of the stressed mice. The increase of DNA 5hmC modification by vitamin C was accompanied with the decrease of R-loop levels; on the contrary, the decrease of DNA 5hmC modification by a small compound SC-1 increased the R-loop levels, indicating that 5hmC modification inversely regulates R-loop accumulation. Further, we showed that Tet deficiency-induced reduction of DNA 5hmC promoted R-loop accumulation. In addition, Tet proteins immunoprecipitated with Non-POU domain-containing octamer-binding (NONO) proteins. The deficiency of Tet proteins or NONO increased R-loop levels, but silencing Tet proteins and NONO did not further increase the increase accumulation, suggesting that NONO and Tet proteins formed a complex to inhibit R-loop formation. It was worth noting that NONO protein levels decreased in the PFC of stressed mice with R-loop accumulation. The administration of antidepressant fluoxetine to stressed mice increased NONO protein levels, and effectively decreased R-loop accumulation and DNA damage. In conclusion, we showed that DNA 5hmC modification negatively regulates R-loop accumulation by the NONO-Tet complex under stress. Our findings provide potential therapeutic targets for depression.
Role of personal aptitudes as determinants of incident morbidity, lifestyles, quality of life, use of the health services and mortality (DESVELA cohort): qualitative study protocol for a prospective cohort study in a hybrid analysis
Authors: Young-Silva Yudy , Berenguera Anna , Jacques-Aviñó Constanza , Gil-Girbau Montserrat , Arroyo-Uriarte Paula , Chela-Alvarez Xenia , Ripoll Joana , Martí-Lluch Ruth , Ramos Rafel , Elizondo-Alzola Usue , Garcia-Martinez Sandra , Méndez-López Fátima , Tamayo-Morales Olaya , Martínez-Andrés Mária , Motrico Emma , Gómez-Gómez Irene , Fernández-Alvarez Roberto , Juvinyà-Canal Dolors ,   the DESVELA Cohort investigators
Published: June 2023

Introduction

Maintaining or acquiring healthier health-oriented behaviours and promoting physical and mental health amongst the Spanish population is a significant challenge for Primary Health Care. Although the role of personal aptitudes (characteristics of each individual) in influencing health behaviours is not yet clear, these factors, in conjunction with social determinants such as gender and social class, can create axes of social inequity that affect individuals’ opportunities to engage in health-oriented behaviours. Additionally, lack of access to health-related resources and opportunities can further exacerbate the issue for individuals with healthy personal aptitudes. Therefore, it is crucial to investigate the relationship between personal aptitudes and health behaviours, as well as their impact on health equity.

Objectives

This paper outlines the development, design and rationale of a descriptive qualitative study that explores in a novel way the views and experiences on the relationship between personal aptitudes (activation, health literacy and personality traits) and their perception of health, health-oriented behaviours, quality of life and current health status.

Method and analysis

This qualitative research is carried out from a phenomenological perspective. Participants will be between 35 and 74 years of age, will be recruited in Primary Health Care Centres throughout Spain from a more extensive study called DESVELA Cohort. Theoretical sampling will be carried out. Data will be collected through video and audio recording of 16 focus groups in total, which are planned to be held in 8 different Autonomous Communities, and finally transcribed for a triangulated thematic analysis supported by the Atlas-ti program.

Discussion

We consider it essential to understand the interaction between health-related behaviours as predictors of lifestyles in the population, so this study will delve into a subset of issues related to personality traits, activation and health literacy.

Clinical trial registration: ClinicalTrials.gov, identifier NCT04386135.
Enabling data sharing and utilization for African population health data using OHDSI tools with an OMOP-common data model
Authors: Kiwuwa-Muyingo Sylvia , Todd Jim , Bhattacharjee Tathagata , Taylor Amelia , Greenfield Jay
Published: June 2023

The COVID-19 pandemic has spurred the use of AI and DS innovations in data collection and aggregation. Extensive data on many aspects of the COVID-19 has been collected and used to optimize public health response to the pandemic and to manage the recovery of patients in Sub-Saharan Africa. However, there is no standard mechanism for collecting, documenting and disseminating COVID-19 related data or metadata, which makes the use and reuse a challenge. INSPIRE utilizes the Observational Medical Outcomes Partnership (OMOP) as the Common Data Model (CDM) implemented in the cloud as a Platform as a Service (PaaS) for COVID-19 data. The INSPIRE PaaS for COVID-19 data leverages the cloud gateway for both individual research organizations and for data networks. Individual research institutions may choose to use the PaaS to access the FAIR data management, data analysis and data sharing capabilities which come with the OMOP CDM. Network data hubs may be interested in harmonizing data across localities using the CDM conditioned by the data ownership and data sharing agreements available under OMOP's federated model. The INSPIRE platform for evaluation of COVID-19 Harmonized data (PEACH) harmonizes data from Kenya and Malawi. Data sharing platforms must remain trusted digital spaces that protect human rights and foster citizens' participation is vital in an era where information overload from the internet exists. The channel for sharing data between localities is included in the PaaS and is based on data sharing agreements provided by the data producer. This allows the data producers to retain control over how their data are used, which can be further protected through the use of the federated CDM. Federated regional OMOP-CDM are based on the PaaS instances and analysis workbenches in INSPIRE-PEACH with harmonized analysis powered by the AI technologies in OMOP. These AI technologies can be used to discover and evaluate pathways that COVID-19 cohorts take through public health interventions and treatments. By using both the data mapping and terminology mapping, we construct ETLs that populate the data and/or metadata elements of the CDM, making the hub both a central model and a distributed model.
Health-related quality of life of children with Williams syndrome and caregivers in China
Authors: Chen Weijun , Sun Lidan , He Xinyu , Li Ziqiao , Ji Chai , Li Fangfang , Shen Jiyang , Pan Tianxin , Jin Xuejing , Dong Yusang , Hu Lidan , Zou Chaochun , Bai Guannan
Published: June 2023

Introduction

Williams syndrome (WS) is a rare genetic disorder that impacts multiple systems and may cause developmental delays. These medical and developmental issues impose a heavy burden on affected children and their families. However, there was no study on children’s health-related quality of life (HRQoL) with WS and only two studies about family quality of life globally. Therefore, the primary purpose of this study was to assess the HRQoL of children with WS and their caregivers in China, and the secondary purpose was to identify the potential determinants of children’s and caregivers’ HRQoL.

Methods

In total, 101 children and caregivers were included. We applied the proxy-reported PedsQL 4.0 Generic Core Module (PedsQL GCM) and PedsQL 3.0 Family Impact Module (FIM) to measure the HRQoL of children and caregivers. Additionally, we collected information on a comprehensive set of social demographic and clinical characteristics. Differences in HRQoL scores across subgroups were assessed by two-independent-samples t-tests, one-way ANOVA, and post hoc tests. We also calculated effect sizes to indicate clinical relevance. Multivariate linear regression models were applied to assess the potential determinants of HRQoL.

Results

We found that the HRQoL of children with WS and their caregivers was dramatically worse than the norm average scores of the healthy controls of children published in previous studies. Paternal educational level, household income, and the perceived financial burden significantly influenced the HRQoL of both children and families (p-values < 0.05). Multivariate linear regression analysis showed that the perceived financial burden was independently associated with family quality of life (p-values < 0.05)., and the presence of sleeping problem was independently associated with children’s HRQoL (p-value = 0.01).

Conclusion

We call for attention from policymakers and other stakeholders on the health status and well-being of children with WS and their families. Supports are needed to relieve psychosocial distress and financial burden.
Drinking water contamination potential and associated factors among households with under-five children in rural areas of Dessie Zuria District, Northeast Ethiopia
Authors: Berihun Gete , Abebe Masresha , Hassen Seada , Gizeyatu Adinew , Berhanu Leykun , Teshome Daniel , Walle Zebader , Desye Belay , Sewunet Birhanu , Keleb Awoke
Published: June 2023

Objective

More than half of the 700 million people worldwide who lack access to a safe water supply live in sub-Saharan Africa, including Ethiopia. Globally, approximately 2 billion people use drinking water sources that are contaminated with fecal matter. However, little is known about the relationship between fecal coliforms and determinants in drinking water. Therefore, the objective of this study was to investigate the potential for contamination of drinking water and its associated factors in households with children under 5 years of age in Dessie Zuria district in northeastern Ethiopia.

Methods

The water laboratory was conducted based on the American Public Health Association guidelines for water and wastewater assessment using a membrane filtration technique. A structured and pre-tested questionnaire was used to identify factors associated with the potential for contamination of drinking water in 412 selected households. A binary logistic regression analysis was performed to determine the factors associated with the presence or absence of fecal coliforms in drinking water, with a 95% confidence interval (CI) and a value ofp ≤ 0.05. The overall goodness of the model was tested using the Hosmer-Lemeshow test, and the model was fit.

Results

A total of 241 (58.5%) households relied on unimproved water supply sources. In addition, approximately two-thirds 272 (66.0%) of the household water samples were positive for fecal coliform bacteria. Water storage duration ≥3 days (AOR = 4.632; 95% CI: 1.529–14.034), dipping method of water withdrawal from a water storage tank (AOR = 4.377; 95% CI: 1.382–7.171), uncovered water storage tank at control (AOR = 5.700; 95% CI: 2.017–31.189), lack of home-based water treatment (AOR = 4.822; 95% CI: 1.730–13.442), and unsafe household liquid waste disposal methods (AOR = 3.066; 95% CI: 1.706–8.735) were factors significantly associated with the presence of fecal contamination in drinking water.

Conclusion

Fecal contamination of water was high. The duration of water storage, the method of water withdrawal from the storage container, covering of the water storage container, the presence of home-based water treatment, and the method of liquid waste disposal were factors for fecal contamination in drinking water. Therefore, health professionals should continuously educate the public on proper water use and water quality assessment.
Male infertility and the human microbiome
Authors: Magill Resa G. , MacDonald Susan M.
Published: June 2023

The historical belief in urology was that the genitourinary system should be sterile in a normal, healthy, asymptomatic adult. This idea was perpetuated for decades until research revealed a diverse microbiota existing in human anatomical niches that contributed to both human health and disease processes. In recent years, the search for an etiology and modifiable risk factors in infertility has turned to the human microbiome as well. Changes in the human gut microbiome have been associated with changes in systemic sex hormones and spermatogenesis. Certain microbial species are associated with higher levels of oxidative stress, which may contribute to an environment higher in oxidative reactive potential. Studies have demonstrated a link between increased oxidative reactive potential and abnormal semen parameters in infertile men. It has also been hypothesized that antioxidant probiotics may be able to correct an imbalance in the oxidative environment and improve male fertility, with promising results in small studies. Further, the sexual partner's microbiome may play a role as well; studies have demonstrated an overlap in the genitourinary microbiomes in sexually active couples that become more similar after intercourse. While the potential applications of the microbiome to male fertility is exciting, there is a need for larger studies with uniform microbial sequencing procedures to further expand this topic.
Ecosystem services produced by groundwater dependent ecosystems: a framework and case study in California
Authors: Howard Jeanette K. , Dooley Katherine , Brauman Kate A. , Klausmeyer Kirk R. , Rohde Melissa M.
Published: June 2023

Groundwater is an important freshwater supply for agricultural, domestic, and environmental uses and critical buffer against a warming climate, particularly in semi-arid and arid regions of the world. Groundwater dependent ecosystems (GDEs), which rely on groundwater for some or all of their water requirements, include terrestrial vegetation, rivers, springs, wetlands, and riparian zones. These GDEs provide benefits to people ranging from habitat for pollinators to carbon sequestration. Accounting for these benefits, called ecosystem services, can inform management by expanding the potential group of groundwater users to include groundwater dependent ecosystems. Here we develop an approach to inventory the ecosystem services of GDEs by identifying the ecosystem functions of a range of GDEs and assessing how they are linked to a wide range of ecosystem services. We apply this approach as a case study in California, USA, where we found ecosystem services from GDEs is widespread across the state; over 30% of California's pollinator dependent crops may benefit from GDEs, and carbon storage of GDEs is equivalent to 790 million tons, twice as much as California emits annually.
Comparison of Two Versus Three Bilateral Botulinum Toxin Injections Prior to Abdominal Wall Reconstruction
Authors: Timmer Allard S. , Ibrahim Faduma , Claessen Jeroen J. M. , Aehling Carolin J. , Kemper Tom C. P. M. , Rutten Martin V. H. , Boermeester Marja A.
Published: June 2023

Background: Intramuscular injection of botulinum toxin A (BTA) induces a temporary muscle paralysis. In patients with a ventral hernia, preoperative injection of BTA in the muscles of the lateral abdominal wall (LAW) leads to thinning and lengthening of these muscles, making fascial closure more likely. In many hernia centres, treatment with BTA prior to abdominal wall reconstruction has therefore become standard care. However, evidence on the optimal BTA strategy is lacking.

Methods: In this single-centre retrospective study, we analysed a consecutive cohort of ventral hernia patients that underwent bilateral BTA injections prior to abdominal wall reconstruction with available CT before and after BTA. We only included patients that were treated with exactly 600 units of Dysport®, diluted into 120 mL of saline, via either two- or three injections on each side into all three LAW muscle layers. The primary outcome was the change in LAW muscle length and thickness, comparing CT measures from before BTA and 4–6 weeks after the injections.

Results: We analysed 67 patients; 30 had received two injections bilaterally and 37 had received three injections bilaterally. Baseline data showed no significant differences in LAW muscle thickness or length between groups. In both groups, the median LAW muscle thickness decreased with 0.5 cm (p < 0.001). The LAW muscle length increased with 0.9 cm (p = 0.001) and 1.2 cm (p < 0.001) in the two- and three bilateral injection group, respectively. The BTA-induced changes in LAW thickness and length were not significantly different between both groups (p = 0.809 and p = 0.654, respectively).

Discussion: When using the exact same dosage and distribution volume of BTA in patients with a complex abdominal wall defect, two injections bilaterally in the lateral abdominal wall muscles are as effective as three injections bilaterally.
Case Report: Brainstem angiocentric glioma presenting in a toddler child–diagnostic and therapeutic challenges
Authors: Reisz Zita , Radics Bence Laszlo , Nemes Peter , Laxton Ross , Kaizer Laszlo , Gabor Krisztina Mita , Novak Timea , Barzo Pal , Al-Sarraj Safa , Bodi Istvan
Published: June 2023

Introduction: Angiocentric gliomas (AG) in brainstem location are exceedingly rare and might cause differential diagnostic problems and uncertainty regarding the best therapeutic approach. Hereby, we describe the clinicopathological findings in a brainstem AG presenting in a toddler child and review the literature.

Case report: A 2-year-old boy presented with 5 weeks history of gait disturbances, frequent falls, left-sided torticollis and swallowing problems. MRI head showed a T2-hyperintense, partly exophytic mass lesion centred in the pontomedullary region, raising the possibility of diffuse midline glioma. The exophytic component was partially resected by suboccipital craniotomy, leaving intact the infiltrative component. Ventriculoperitoneal shunt was implanted due to postoperative hydrocephalus. Histological examination revealed a moderately cellular tumour consisted of bland glial cells infiltrating the brain parenchyma and radially arranged around the blood vessels. By immunohistochemistry, the tumour strongly expressed S100 and GFAP in addition to intense nestin positivity, while OLIG2 was negative in the perivascular tumour cells. DNA methylation array profiled the tumour as “methylation class diffuse astrocytoma, MYB or MYBL1-altered subtype B (infratentorial)” and an in-frame MYB::QKI fusion was identified by RNA sequencing, confirming the diagnosis of angiocentric glioma. The patient has been initially treated with angiogenesis inhibitor and mTOR inhibitor, and now he is receiving palliative vinblastine. He is clinically stable on 9 months follow-up.

Conclusion: Brainstem AG may cause a diagnostic problem, and the surgical and oncological management is challenging due to unresectability and lack of response to conventional chemo-radiation. In the future, genetically-tailored therapies might improve the prognosis.
Generalized Algorithm Based on Equivalent Circuits for Evaluating Shielding Effectiveness of Electronic Equipment Enclosures
Authors: Ivanov Anton A. , Kvasnikov Aleksey A. , Demakov Alexander V. , Komnatnov Maxim E. , Kuksenko Sergei P. , Gazizov Talgat R.
Published: June 2023

The article proposes a generalized algorithm for evaluating the shielding effectiveness (SE) of electronic equipment enclosures. The algorithm is based on a number of analytical models that use equivalent circuits to obtain SE values. The article begins with a brief review and interpretation of the mathematical formulation used in the algorithm. Then, we describe the proposed algorithm using flowcharts, and we perform its validation. The validation results show that the proposed algorithm has acceptable accuracy and gives SE values comparable to numerical methods or measurements, with much less time costs. The last part of the article presents the software developed to evaluate SE based on analytical models.
Design and Experimental Testing of an Ankle Rehabilitation Robot
Authors: Doroftei Ioan , Cazacu Cristina-Magda , Alaci Stelian
Published: June 2023

The ankle joint (AJ) is a crucial joint in daily life, responsible for providing stability, mobility, and support to the lower limbs during routine activities such as walking, jumping, and running. Ankle joint injuries can occur due to sudden twists or turns, leading to ligament sprains, strains, fractures, and dislocations that can cause pain, swelling, and limited mobility. When AJ trauma occurs, joint instability happens, causing mobility limitations or even a loss of joint mobility, and rehabilitation therapy is necessary. AJ rehabilitation is critical for those recovering from ankle injuries to regain strength, stability, and function. Common rehabilitation methods include rest, ice, compression, and elevation (RICE), physical therapy, ankle braces, and exercises to strengthen the surrounding muscles. Traditional rehabilitation therapies are limited and require constant presence from a therapist, but technological advancements offer new ways to fully recover from an injury. In recent decades there has been an upswing in research on robotics, specifically regarding rehabilitation. Robotic platforms (RbPs) offer several advantages for AJ rehabilitation assistance, including customized training programs, real-time feedback, improved performance monitoring, and increased patient engagement. These platforms use advanced technologies such as sensors, actuators, and virtual reality to help patients recover quicker and more efficiently. Furthermore, RbPs can provide a safe and controlled environment for patients who need to rebuild their strength and mobility. They can enable patients to focus on specific areas of weakness or instability and provide targeted training for faster recovery and reduced risk of re-injury. Unfortunately, high costs make it difficult to implement these systems in recuperative institutions, and the need for low-cost platforms is apparent. While different systems are currently being used, none of them fully satisfy patient needs or they lack technical problems. This paper addresses the conception, development, and implementation of rehabilitation platforms (RPs) that are adaptable to patients’ needs by presenting different design solutions (DSs) of ankle RPs, mathematical modeling, and simulations of a selected rehabilitation platform (RP) currently under development. In addition, some results from practical tests of the first prototype of this RP are presented. One patient voluntarily agreed to use this platform for more rehabilitation sessions on her AJ (right leg). To counteract some drawbacks of the first prototype, some improvements in the RP design have been proposed. The results on testing the improved prototype will be the subject of future work.
Evaluation and Simulation Analysis of Mixing Performance for Gas Fuel Direct Injection Engine under Multiple Working Conditions
Authors: Wang Hongchen , Wang Tianbo , Chen Jing , Zhang Lanchun , Zheng Yan , Li Li , Sun Yanyun
Published: June 2023

Gas fuel direct injection (DI) technology can improve the control precision of the in-cylinder mixing and combustion process and effectively avoid volumetric efficiency reduction in a compressed natural gas (CNG) engine, which has been a tendency. However, compared with the port fuel injection (PFI) method, the former’s mixing path and duration are shortened greatly, which often leads to poor mixing uniformity. What is worse, the in-cylinder mixing performance would be seriously affected by engine working conditions, such as engine speed and load. Based on this situation, the fluid mechanics software FLUENT is used in this article, and the computational fluid dynamics (CFD) model of the injection and mixing process in a gas-fueled direct injection engine is established. A quantitative evaluation mechanism of the in-cylinder mixing performance of the CNG engine is proposed to explore the influencing rule of different engine speeds and loads on the mixing process and performance. The results indicate that phase space analysis can accurately reflect the characteristics of the mixture mixing process. The gas fuel mixture rapidly occupies the cylinder volume in the injection stage. During the transition stage, the gas fuel mixture is in a highly transient state. The diffusion stage is characterized by the continuous homogenization of the mixture. The in-cylinder mixing performance is linearly dependent on the engine’s working condition in the phase space.
Partitioning Evapotranspiration in a Cotton Field under Mulched Drip Irrigation Based on the Water-Carbon Fluxes Coupling in an Arid Region in Northwestern China
Authors: Liu Yanxue , Qiao Changlu
Published: June 2023

Measuring evapotranspiration (ET) components in cotton fields under mulched drip irrigation is needed to improve water use efficiency and promote the development of water-saving agriculture. In this study, an Eddy Covariance (EC) system was used to observe the water-carbon fluxes of cotton fields under mulched drip irrigation in an arid region during two years (2021–2022). The Underlying Water Use Efficiency (uWUE) method was used to partition the ET into transpiration (T) and evaporation (E) in order to reveal the changing characteristics of ET and its components in cotton fields under mulched drip irrigation and analyze the effects of environmental factors on each component. The results showed that the diurnal variation of ET was the same as gross primary productivity (GPP), and their course of change showed a bimodal curve at budding, blooming, and boll stages. The relationship of T at different growth stages was the same as ET, which is blooming and boll stage > budding stage > boll opening stage > seedling stage. ET and its components were mainly affected by temperature (Tair) and net radiation (Rn). This study can provide a theoretical and practical basis for the application of uWUE in cotton fields under mulched drip irrigation and a scientific basis for the rational allocation of water resources and the formulation of a scientific water-saving irrigation system for farmland in an arid region.