bluuebunny/crossref_metadata_2025 huggingface dataset:
Attributable risk of carpal tunnel syndrome according to industry and occupation in a general population
Authors: Roquelaure Yves , Ha Catherine , Nicolas Guillaume , Pélier‐Cady Marie‐Christine , Mariot Camille , Descatha Alexis , Leclerc Annette , Raimbeau Guy , Goldberg Marcel , Imbernon Ellen
Published: August 2008

Objective

An epidemiologic surveillance network for carpal tunnel syndrome (CTS) was set up in the general population of a French region to assess the proportion of CTS cases attributable to work in high‐risk industries and occupations.

Methods

Cases of CTS occurring among patients ages 20–59 years living in the Maine and Loire region were included prospectively from 2002 to 2004. Medical and occupation history was gathered by mailed questionnaire for 815 women and 320 men. Age‐adjusted relative risks of CTS and the attributable risk fractions of CTS among exposed persons (AFEs) were computed in relation to industry sectors and occupation categories.

Results

Twenty‐one industry sectors and 8 occupational categories for women and 10 sectors and 6 occupational categories for men were characterized by a significant excess risk of CTS. High AFE values were observed in the manufacturing (42–93% for both sexes), construction (66% for men), and personal service industries (66% for women) and in the trade and commerce sectors (49% for women). High AFE values were observed in lower‐grade white‐collar occupations for women (43–67%) and blue‐collar occupations for men (60–74%) and women (48–88%).

Conclusion

The attributable proportions of CTS cases among workers employed in industry sectors and occupation categories identified at high risk of CTS varied between 36% and 93%.
Subclinical carotid atherosclerosis in patients with psoriatic arthritis
Authors: Tam Lai‐Shan , Shang Qing , Li Edmund K. , Tomlinson Brian , Chu Tanya T. W. , Li Martin , Leung Ying‐Ying , Kwok Lai‐Wa , Wong Kong‐Chiu , Li Tena K. , Yu Tracey , Zhu Tracy Y. , Kun Emily W. , Yip Gabriel W. , Yu Cheuk‐Man
Published: August 2008

Objective

To examine the prevalence of subclinical atherosclerosis in patients with psoriatic arthritis (PsA) compared with healthy controls, and to identify clinical and biologic markers for atherosclerotic disease in this patient population.

Methods

Subclinical atherosclerosis was defined as the average of intima‐media thickness (IMT) measures in the common carotid artery, bifurcation, and internal carotid artery on both sides above the 95th percentile of healthy controls. IMT was measured using carotid ultrasonography in 82 consecutive PsA patients and 82 healthy controls matched on age, sex, and ethnicity. We also ascertained traditional and novel cardiovascular (CV) risk factors, Framingham risk score (FRS), disease severity, treatment, and inflammatory markers in all PsA patients.

Results

No PsA patients had clinically overt CV diseases. After adjusting for traditional CV risk factors, PsA patients had a higher prevalence of subclinical atherosclerosis. PsA patients with subclinical atherosclerosis had significantly increased sugar, total triglyceride levels, total cholesterol/high‐density cholesterol, white cell count, and patients' global assessment score compared with those without subclinical atherosclerosis. Using logistic regression analysis, independent explanatory variables associated with subclinical atherosclerosis in PsA included increased sugar and total triglyceride levels. The FRS was similar in PsA patients with or without subclinical atherosclerosis. Twenty‐six (35%) of 74 patients had subclinical atherosclerosis despite having a low CV risk.

Conclusion

PsA is associated with subclinical atherosclerosis after adjusting for traditional CV risk factors. Independent explanatory variables associated with subclinical atherosclerosis in PsA included increased sugar and total triglyceride levels. Carotid IMT can identify PsA patients with subclinical atherosclerosis who may benefit from early intervention.
How accurate are diagnoses for rheumatoid arthritis and juvenile idiopathic arthritis in the general practice research database?
Authors: Thomas S. L. , Edwards C. J. , Smeeth L. , Cooper C. , Hall A. J.
Published: August 2008

Objective

To identify characteristics that predict a valid rheumatoid arthritis (RA) or juvenile idiopathic arthritis (JIA) diagnosis among RA‐ and JIA‐coded individuals in the General Practice Research Database (GPRD), and to assess limitations of this type of diagnostic validation.

Methods

Four RA and 2 JIA diagnostic groups were created with differing strengths of evidence of RA/JIA (Group 1 = strongest evidence), based on RA/JIA medical codes. Individuals were sampled from each group and clinical and prescription data were extracted from anonymized hospital/practice correspondence and electronic records. American College of Rheumatology and International League of Associations for Rheumatology diagnostic criteria were used to validate diagnoses. A data‐derived diagnostic algorithm that maximized sensitivity and specificity was identified using logistic regression.

Results

Among 223 RA‐coded individuals, the diagnostic algorithm classified individuals as having RA if they had an appropriate GPRD disease‐modifying antirheumatic drug prescription or 3 other GPRD characteristics: >1 RA code during followup, RA diagnostic Group 1 or 2, and no later alternative diagnostic code. This algorithm had >80% sensitivity and specificity when applied to a test data set. Among 101 JIA‐coded individuals, the strongest predictor of a valid diagnosis was a Group 1 diagnostic code (>90% sensitivity and specificity).

Conclusion

Validity of an RA diagnosis among RA‐coded GPRD individuals appears high for patients with specific characteristics. The findings are important for both interpreting results of published GPRD studies and identifying RA/JIA patients for future GPRD‐based research. However, several limitations were identified, and further debate is needed on how best to validate chronic disease diagnoses in the GPRD.
Lifetime risk of symptomatic knee osteoarthritis
Authors: Murphy Louise , Schwartz Todd A. , Helmick Charles G. , Renner Jordan B. , Tudor Gail , Koch Gary , Dragomir Anca , Kalsbeek William D. , Luta Gheorghe , Jordan Joanne M.
Published: August 2008

Objective

To estimate the lifetime risk of symptomatic knee osteoarthritis (OA), overall and stratified by sex, race, education, history of knee injury, and body mass index (BMI).

Methods

The lifetime risk of symptomatic OA in at least 1 knee was estimated from logistic regression models with generalized estimating equations among 3,068 participants of the Johnston County Osteoarthritis Project, a longitudinal study of black and white women and men age ≥45 years living in rural North Carolina. Radiographic, sociodemographic, and symptomatic knee data measured at baseline (1990–1997) and first followup (1999–2003) were analyzed.

Results

The lifetime risk of symptomatic knee OA was 44.7% (95% confidence interval [95% CI] 40.0–49.3%). Cohort members with history of a knee injury had a lifetime risk of 56.8% (95% CI 48.4–65.2%). Lifetime risk rose with increasing BMI, with a risk of 2 in 3 among those who were obese.

Conclusion

Nearly half of the adults in Johnston County will develop symptomatic knee OA by age 85 years, with lifetime risk highest among obese persons. These current high risks in Johnston County may suggest similar risks in the general US population, especially given the increase in 2 major risk factors for knee OA, aging, and obesity. This underscores the immediate need for greater use of clinical and public health interventions, especially those that address weight loss and self‐management, to reduce the impact of having knee OA.
PtII Complexes with 6‐(5‐Trifluoromethyl‐Pyrazol‐3‐yl)‐2,2′‐Bipyridine Terdentate Chelating Ligands: Synthesis, Characterization, and Luminescent Properties
Authors: Chen Jing‐Lin , Chang Sheng‐Yuan , Chi Yun , Chen Kellen , Cheng Yi‐Ming , Lin Chun‐Wei , Lee Gene‐Hsiang , Chou Pi‐Tai , Wu Chen‐Hao , Shih Ping‐I , Shu Ching‐Fong
Published: September 2008

A series of PtII complexes Pt(fpbpy)Cl (1), Pt(fpbpy)(OAc) (2), Pt(fpbpy)(NHCOMe) (3), Pt(fpbpy)(NHCOEt) (4), and [Pt(fpbpy)(NCMe)](BF4) (5) with deprotonated 6‐(5‐trifluoromethyl‐pyrazol‐3‐yl)‐2,2′‐bipyridine terdentate ligand are prepared, among which 1 is converted to complexes 2–5 by a simple ligand substitution. Alternatively, acetamide complex 3 is prepared by hydrolysis of acetonitrile complex 5, while the back conversion from 3 to 1 is regulated by the addition of HCl solution, showing the reaction sequence 1→5→3→1. Multilayer OLED devices are successfully fabricated by using triphenyl‐(4‐(9‐phenyl‐9H‐fluoren‐9‐yl)phenyl) silane (TPSi‐F) as host material and with doping concentrations of 1 varying from 7 to 100 %. The electroluminescence showed a substantial red‐shifting versus the normal photoluminescence detected in solution. Moreover, at a doping concentration of 28 %, the device showed a saturated red luminescence with a maximum external quantum yield of 8.5 % at 20 mA cm−2 and a peak luminescence of 47 543 cd m−2 at 18.5 V.
Synthesis, Crystal Structure, Bonding, and Properties of (Ba6O)(OsN3)2
Authors: Schmidt Carsten L. , Wedig Ulrich , Dinnebier Robert , Jansen Martin
Published: August 2008

The new barium nitridoosmate oxide (Ba6O)(OsN3)2 was prepared by reacting elemental barium and osmium (3:1) in nitrogen at 815–830 °C. The crystal structure of (Ba6O)(OsN3)2 as determined by laboratory powder X‐ray diffraction (${R\bar 3}$, No 148: a=b=8.112(1) Å, c=17.390(1) Å, V=991.0(1) Å3, Z=3), consists of sheets of trigonal OsN3 units and trigonal‐antiprismatic Ba6O groups, and is structurally related to the “313 nitrides” AE3MN3 (AE=Ca, Sr, Ba, M=V–Co, Ga). Density functional calculations, using a hybrid functional, likewise indicate the existence of oxygen in the Ba6 polyhedra. The oxidation state 4+ of osmium is confirmed, both by the calculations and by XPS measurements. The bonding properties of the OsN35− units are analyzed and compared to the Raman spectrum. The compound is paramagnetic from room temperature down to T=10 K. Between room temperature and 100 K it obeys the Curie–Weiss law (μ=1.68 μB). (Ba6O)(OsN3)2 is semiconducting with a good electronic conductivity at room temperature (8.74×10−2 Ω−1 cm−1). Below 142 K the temperature dependence of the conductivity resembles that of a variable‐range hopping mechanism.
Stützen‐Deckenknoten für Schleuderbetonstützen
Authors: Rinnhofer Gerhard , Burtscher Stefan L. , Kollegger Johann
Published: August 2008

Der vorliegende Artikel behandelt Knoten zwischen hochtragfähigen Schleuderbetonstützen mit Längsbewehrungsgraden bis 14,7% und Deckenplatten aus Normalbeton. Das Augenmerk wird hierbei auf die Durchleitung der Stützenlasten durch die Decke gelegt, wobei auch die Längsbewehrung der Stützen im Knoten unterbrochen ist.

Für Schleuderbetonstützen wird eine optimierte Lösung mit einem hochfesten Kern vorgestellt. In Versuchen werden die herkömmlichen Knotendetails und die Ausführung mit hochfestem Kern miteinander verglichen. Es zeigt sich, dass mit der neuen Ausführung nicht nur höhere Lasten erreicht werden können, sondern auch überproportional große Deformationen der Decke, wie dies bei herkömmlichen Ausführungen der Fall sein kann, vermieden werden können. Auf Basis der Versuchdaten wird ein Bemessungsmodell präsentiert, welches in einfacher Weise die Bemessung solcher Knotendetails ermöglicht.
Flexibility of the MHC class II peptide binding cleft in the bound, partially filled, and empty states: A molecular dynamics simulation study
Authors: Yaneva Rakina , Springer Sebastian , Zacharias Martin
Published: September 2008

Major histocompatibility (MHC) Class II cell surface proteins present antigenic peptides to the immune system. Class II structures in complex with peptides but not in the absence of peptide are known. Comparative molecular dynamics (MD) simulations of a Class II protein (HLA‐DR3) with and without CLIP (invariant chain‐associated protein) peptide were performed starting from the CLIP‐bound crystal structure. Depending on the protonation of acidic residues in the P6 peptide‐binding pocket the simulations stayed overall close to the start structure. The simulations without CLIP showed larger conformational fluctuations especially of α‐helices flanking the binding cleft. Largest fluctuations without CLIP were observed in a helical segment near the peptide C‐terminus binding region matching a segment recognized by antibodies specific for empty Class II proteins. Simulations on a Val86Tyr mutation that fills the peptide N‐terminus binding P1 pocket or of a complex with a CLIP fragment (dipeptide) bound to P1 showed an unexpected long range effect. In both simulations the mobility not only of P1 but also of the entire binding cleft was reduced compared to simulations without CLIP. It correlates with the experimental finding that the CLIP fragment binding to P1 is sufficient to prevent antibody recognition specific for the empty form at a site distant from P1. The results suggest a mechanism how a local binding event of small peptides or of an exchange factor near P1 may promote peptide binding and exchange through a long range stabilization of the whole binding cleft in a receptive (near bound) conformation. © 2008 Wiley Periodicals, Inc. Biopolymers 91: 14–27, 2009.

This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Amyloidogenic potential of α‐chymotrypsin in different conformational states
Authors: Rezaei‐Ghaleh Nasrollah , Zweckstetter Markus , Morshedi Dina , Ebrahim‐Habibi Azadeh , Nemat‐Gorgani Mohsen
Published: September 2008

Amyloid fibril formation is widely believed to be a generic property of polypeptide chains. In the present study, α‐chymotrypsin, a well‐known serine protease has been driven toward these structures by the use of two different conditions involving (I) high temperature, pH 2.5, and (II) low concentration of trifluoroethanol (TFE), pH 2.5. A variety of experimental methods, including fluorescence emission, dynamic quenching, steady‐state fluorescence anisotropy, far‐UV circular dichroism, nuclear magnetic resonance spectroscopy, and dynamic light scattering were employed to characterize the conformational states of α‐chymotrypsin that precede formation of amyloid fibrils. The structure formed under Condition I was an unfolded monomer, whereas an α‐helical rich oligomer was induced in Condition II. Both the amyloid aggregation‐prone species manifested a higher solvent exposure of hydrophobic and aromatic residues compared with the native state. Upon incubation of the protein in these conditions for 48 h, amyloid‐like fibrils were formed with diameters of about 10–12 nm. In contrast, at neutral pH and low concentration of TFE, a significant degree of amorphous aggregation was observed, suggesting that charge neutralization of acidic residues in the amyloid core region has a positive influence on amyloid fibril formation. In summary, results presented in this communication suggest that amyloid fibrils of α‐chymotrypsin may be obtained from a variety of structurally distinct conformational ensembles highlighting the critical importance of protein evolution mechanisms related to prevention of protein misfolding. © 2008 Wiley Periodicals, Inc. Biopolymers 91: 28–36, 2009.

This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Application of a fuzzy logic control system for continuous anaerobic digestion of low buffered, acidic energy crops as mono‐substrate
Authors: Scherer P. , Lehmann K. , Schmidt O. , Demirel B.
Published: August 2008

A fuzzy logic control (FLC) system was developed at the Hamburg University of Applied Sciences (HAW Hamburg) for operation of biogas reactors running on energy crops. Three commercially available measuring parameters, namely pH, the methane (CH4) content, and the specific gas production rate (spec. GPR = m3/kg VS/day) were included. The objective was to avoid stabilization of pH with use of buffering supplements, like lime or manure. The developed FLC system can cover most of all applications, such as a careful start‐up process and a gentle recovery strategy after a severe reactor failure, also enabling a process with a high organic loading rate (OLR) and a low hydraulic retention time (HRT), that is, a high throughput anaerobic digestion process with a stable pH and CH4 content. A precondition for a high load process was the concept of interval feeding, for example, with 8 h of interval. The FLC system was proved to be reliable during the long term fermentation studies over 3 years in one‐stage, completely stirred tank reactors (CSTR) with acidic beet silage as mono‐input (pH 3.3–3.4). During fermentation of the fodder beet silage (FBS), a stable HRT of 6.0 days with an OLR of up to 15 kg VS/m3/day and a volumetric GPR of 9 m3/m3/day could be reached. The FLC enabled an automatic recovery of the digester after two induced severe reactor failures. In another attempt to prove the feasibility of the FLC, substrate FBS was changed to sugar beet silage (SBS), which had a substantially lower buffering capacity than that of the FBS. With SBS, the FLC accomplished a stable fermentation at a pH level between 6.5 and 6.6, and a volatile fatty acid level (VFA) below 500 mg/L, but the FLC had to interact and to change the substrate dosage permanently. In a further experiment, the reactor temperature was increased from 41 to 50°C. Concomitantly, the specific GPR, pH and CH4 dropped down. Finally, the FLC automatically enabled a complete recovery in 16 days. Biotechnol. Bioeng. 2009; 102: 736–748. © 2008 Wiley Periodicals, Inc.
Randomized clinical trial of groin hernia repair with titanium-coated lightweight mesh compared with standard polypropylene mesh
Authors: Koch A , Bringman S , Myrelid P , Smeds S , Kald A
Published: September 2008

Background

Groin hernia repair is one of the commonest operations in general surgery. Existing techniques have very low and acceptable recurrence rates, but chronic pain and discomfort remain a problem for many patients. New mesh materials are being developed to increase biocompatibility, and the aim of this study was to compare a new titanium-coated lightweight mesh with a standard polypropylene mesh.

Methods

A randomized controlled single-centre clinical trial was designed, with the basic principle of one unit, one surgeon, one technique (Lichtenstein under general anaesthesia) and two meshes. Pain before and after surgery, and during convalescence (primary outcomes) was estimated in 317 patients. At 1-year clinical follow-up, recurrence, pain, discomfort and quality of life (secondary outcomes) were evaluated.

Results

Patients with the lightweight mesh returned to work after 4 days, compared with 6·5 days for the standard mesh (P = 0·040). The lightweight group returned to normal activity after 7 days, versus 10 days for the standard group (P = 0·005). There was no difference in postoperative pain or recurrence at the 1-year follow-up.

Conclusion

Patients with the lightweight mesh had a shorter convalescence than those with the standard heavyweight mesh. Registration number: ISRCTN36979348 (http://www.controlled-trials.com).
Health-related quality of life in patients treated for enterocutaneous fistula
Authors: Visschers R G J , Damink S W M Olde , van Bekkum M , Winkens B , Soeters P B , van Gemert W G
Published: September 2008

Background

Patients with enterocutaneous fistulas undergo long intensive treatment. The aim of this study was to investigate the long-term health-related quality of life (HRQL) of these patients.

Methods

Consecutive patients treated for enterocutaneous fistula between 1990 and 2005 were eligible for this retrospective study. The Karnofsky Performance Scale (KPS), Short Form 36 (SF-36®) and the Inflammatory Bowel Disease Questionnaire were used to measure HRQL. The SF-36® was matched with results from healthy controls. Patients also gave information on concurrent medical illnesses.

Results

Of 135 patients, 44 died, 14 were lost to follow-up and 12 refused to participate; of the remaining 65, 62 participated (response rate 81 per cent). HRQL was independent of patient characteristics during treatment. Scores for SF-36® domains were lower than in their matched controls (P < 0·050). Concurrent medical illness (cancer, depression and gastrointestinal disease) significantly reduced HRQL (for example with a 40 per cent reduction in vitality). The median KPS score was 80, indicating that activities could be performed with effort and patients had some signs of disease.

Conclusion

HRQL is lower in patients treated for enterocutaneous fistula than in matched controls, particularly in those with concurrent medical illnesses. Patients treated successfully have normal independence in daily functioning.
Randomized clinical trial comparing endovenous laser with cryostripping for great saphenous varicose veins
Authors: Disselhoff B C V M , der Kinderen D J , Kelder J C , Moll F L
Published: September 2008

Background

The aim of this randomized single-centre trial was to compare the 2-year results of endovenous laser ablation (EVLA) and cryostripping for varicose veins.

Methods

A total of 120 patients with uncomplicated great saphenous varicose veins were randomized equally to one of the two treatments. Principal outcomes measures were: freedom from recurrent varicose veins on duplex imaging, and improvement in Venous Clinical Severity Score (VCSS) and Aberdeen Varicose Vein Severity Score (AVVSS) 6, 12 and 24 months after treatment.

Results

Life-table analysis showed overall freedom from recurrent incompetence at 2 years in 77 (95 per cent confidence interval (c.i.) 72 to 78) per cent of patients after EVLA and in 66 (95 per cent c.i. 60 to 67) per cent after cryostripping (P = 0·253). VCSS and AVVSS values improved significantly after treatment, but the differences between the treatments were not significant. EVLA provided significantly more favourable results than cryostripping with respect to duration of operation, postprocedural pain, induration and resumption of normal activity.

Conclusion

EVLA and cryostripping were similarly effective in patients with varicose veins, but patients favoured EVLA because of less pain and postoperative morbidity, and quicker return to normal activity. Registration number: ISRCTN33832691 (http://www.controlled-trials.com).
Vicarious and post‐memory practices in adopting families: The re‐production of the past through photography and narrative
Authors: Brookfield Helen , Brown Steven D. , Reavey Paula
Published: September 2008

In this paper, we explore how adoptive parents manage and order visual information relating to their adoptive child's birth or foster family. More specifically, our task is to make sense of the ways in which the memories that children have of their past families are (re)constructed and managed within the context of present adoptive parental concerns. Life story books have become a dominant way in which narratives of the child's past family are formed. The aim of this book is to provide the child with relevant information, objects, possessions and images of the past and to create a coherent narrative between the past and the present. Parents are encouraged to make use of visual images, consisting mainly of photographs of birth families and foster carers to order the autobiography of the child. To date, there is no research that has examined how the process is experienced by parents and children. In order to examine how parents made use of visual information in particular, we carried out two focus groups with adoptive parents who participated in an adoption agency support group. A social remembering approach informed the questions asked, and a discursive analysis of the data was developed. The main analytical focus in this paper is on how photographs, objects and places serve as active participants in the production of the adoptive children's memory. Copyright © 2008 John Wiley & Sons, Ltd.
But‐3‐ene‐1,2‐diol: A Mechanism‐Based Active Site Inhibitor for Coenzyme B12‐Dependent Glycerol Dehydratase
Authors: Pierik Antonio J. , Graf Torsten , Pemberton Louise , Golding Bernard T. , Rétey János
Published: September 2008

Coenzyme B12‐dependent glycerol dehydratase is a radical enzyme that catalyses the conversion of glycerol into 3‐hydroxypropanal and propane‐1,2‐diol into propanal via enzyme‐bound intermediate radicals. The substrate analogue but‐3‐ene‐1,2‐diol was studied in the expectation that it would lead to the 4,4‐dihydroxylbut‐2‐en‐1‐yl radical, which is stabilised (allylic) and not reactive enough to retrieve a hydrogen atom from 5′‐deoxyadenosine, thereby interrupting the catalytic cycle. Racemic and enantiomerically pure but‐3‐ene‐1,2‐diols and their [1,1‐2H2], [2‐2H] and [4,4‐2H2] isotopomers were synthesised and characterised by NMR spectroscopy. (S)‐[4‐14C]but‐3‐ene‐1,2‐diol was also prepared. Kinetic measurements showed but‐3‐ene‐1,2‐diol to be a competitive inhibitor of glycerol dehydratase (Ki=0.21 mM, ki=5.0×10−2 s−1). With [4‐14C]but‐3‐ene‐1,2‐diol it was demonstrated that species derived from the diol become tightly bound to the enzyme's active site, but not covalently bound, because the radioactivity could be removed upon denaturation of the enzyme. EPR measurements with propane‐1,2‐diol as substrate generated sharp signals after 10 s that disappeared after about 1 min. In contrast, EPR resonances appeared and disappeared more slowly when but‐3‐ene‐1,2‐diol was incubated with the enzyme. Among the deuterated isotopomers, only [1,1‐2H2]but‐3‐ene‐1,2‐diol showed a significantly different EPR spectrum from that of the unlabelled diol; this indicated that coupling between the unpaired electron and a deuterium at C‐1 was stronger than with deuterium at C‐2 or C‐4. The experiments suggest the formation of the 1,2‐dihydroxybut‐3‐en‐1‐yl radical, which decomposes to unidentified product(s).
Synthesis and Conformational Analysis of Stevastelin C3 Analogues and Their Activity Against the Dual‐Specific Vaccina H1‐Related Phosphatase
Authors: Bisek Nicola , Wetzel Stefan , Arndt Hans‐Dieter , Waldmann Herbert
Published: September 2008

The biological activity of macrocyclic natural products depends on their conformational properties. For both the elucidation of enzyme binding affinities as well as the development of selective drugs, rigid macrocyclic scaffolds carry high potential. In this study, 13‐membered cyclodepsipeptides based on the structure of naturally occurring stevastelins were studied in detail. Six diastereomeric stevastelin C3 analogues and four phosphorylated derivatives were synthesized. The synthesis of linear precursors was achieved on solid support by starting from stereoisomerically pure 2‐methyl‐3‐hydroxy acids. Subsequent macro‐lactamization gave the cyclic depsipeptides in very good yields (36–62 %). The conformational space of these stevastelin C3 analogues was computationally investigated. On the basis of NMR spectroscopic data, homogeneous conformations were determined for each benzylated depsipeptide and the influence of phosphorylation on the overall conformation was investigated. Importantly, phosphorylation was found to significantly weaken the conformational preferences of the 13‐membered depsipeptides. Finally, the cyclic depsipeptides were tested for activity against phosphatases. Inhibitory activity on vaccina H1‐related phosphatase was observed depending on the derivatization of the cycles. The activity profiles are discussed in the light of the structural data.
Organocatalytic Enantioselective Synthesis of Highly Functionalized Polysubstituted Pyrrolidines
Authors: Ruiz Nerea , Reyes Efraím , Vicario Jose L. , Badía Dolores , Carrillo Luisa , Uria Uxue
Published: September 2008

The organocatalytic conjugate addition of different aldehydes to β‐nitroacrolein dimethyl acetal, generating the corresponding highly functionalized nitroaldehydes in high yields and with high stereoselectivities, has been studied in detail. These transformations have been achieved by using both readily available starting materials in a 1:1 ratio as well as commercially available catalysts at a 10 mol % catalyst loading. Furthermore, a very short and efficient protocol has been devised for the preparation of highly enantioenriched pyrrolidines containing two or three contiguous stereocenters starting from the obtained Michael adducts. 3,4‐Disubstituted pyrrolidines have been obtained in a single step by Zn‐mediated chemoselective reduction of the nitro group followed by intramolecular reductive amination, and trisubstituted homoproline derivatives have been prepared by means of an olefination reaction and a cascade process involving chemoselective reduction of the nitro group followed by a fully diastereoselective intramolecular aza‐ Michael reaction.
Recent Advances in “Formal” Ruthenium‐Catalyzed [2+2+2] Cycloaddition Reactions of Diynes to Alkenes
Authors: García‐Rubín Silvia , Varela Jesús A. , Castedo Luis , Saá Carlos
Published: September 2008

“Formal” and standard RuII‐catalyzed [2+2+2] cycloaddition of 1,6‐diynes to alkenes gave bicyclic 1,3‐cyclohexadienes in relatively good yields. When terminal 1,6‐diynes 1 were used, two isomeric bicyclic 1,3‐cyclohexadienes 4 or 6 were obtained, depending on the acyclic or cyclic nature of the alkene partner. When unsymmetrical substituted 1,6‐diynes 7 were used, the reaction with acyclic alkenes took place regio‐ and stereoselectively to afford bicyclic 1,3‐cyclohexadienes 8. A cascade process that behaves as a “formal” RuII‐catalyzed [2+2+2] cycloaddition explained these results. Initially, a Ru‐catalyzed linear coupling of 1,6‐diynes 1 and 7 with acyclic alkenes occurs to give open 1,3,5‐trienes of type 3, which after a thermal disrotatory 6e− π‐electrocyclization led to the final 1,3‐cyclohexadienes 4 and 8. When disubstituted 1,6‐diyne 10 was used with electron‐deficient alkenes, new exo‐methylene cyclohexadienes 12 arose from a competitive reaction pathway.
ChemInform Abstract: Crystal Structure of the Quaternary Alloy CuTaInSe3.
Authors: Delgado G. E. , Mora A. J. , Grima‐Gallardo P. , Duran S. , Munoz M. , Quintero M.
Published: September 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Superconductivity at 43 K in SmFeAsO1‐xFx.
Authors: Chen X. H. , Wu T. , Wu G. , Liu R. H. , Chen H. Chen H. , Fang D. F.
Published: September 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Two‐Band Superconductivity in LaFeAsO0.89F0.11 at Very High Magnetic Fields.
Authors: Hunte F. , Jaroszynski J. , Gurevich A. , Larbalestier D. C. , Jin R. , Sefat A. S. , McGuire M. A. , Sales B. C. , Christen D. K. , Mandrus D.
Published: September 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Gold(III) Chloride‐Catalyzed Diastereoselective Alkylation Reactions with Chiral Benzylic Acetates.
Authors: Rubenbauer Philipp , Bach Thorsten
Published: September 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Efficient Catalysis of Ullmann‐Type Arylation Reactions by a Novel Trinuclear Copper(I) Complex with a Chelating Tricarbene Ligand.
Authors: Tubaro Cristina , Biffis Andrea , Scattolin Elena , Basato Marino
Published: September 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Efficient Base Catalyzed Alkylation Reactions with Aziridine Electrophiles.
Authors: Moss Thomas A. , Alba Aurelie , Hepworth David , Dixon Darren J.
Published: September 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Diketones and ω‐Hydroxy Ketones from Methyl Ketones and α,ω‐Diols by an [IrCl(cod)]2/PPh3/KOH System.
Authors: Maeda Kensaku , Obora Yasushi , Sakaguchi Satoshi , Ishii Yasutaka
Published: September 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Effective Amidation of Carboxylic Acids Using (4,5‐Dichloro‐6‐oxo‐6H‐pyridazin‐1‐yl)phosphoric Acid Diethyl Ester.
Authors: Kang Seung‐Beom , Yim Heung‐Seop , Won Ju‐Eun , Kim Min‐Jung , Kim Jeum‐Jong , Kim Ho‐Kyun , Lee Sang‐Gyeong , Yoon Yong‐Jin
Published: September 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemoselective and Efficient Method for Deprotection of THP and Silyl Ethers with H2O2/Mn(III) Schiff‐Base Complex.
Authors: Tajbakhsh Mahmood , Hosseinzadeh Rahman , Golchoubian Hamid , Razavian Raheleh
Published: September 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereoselective Nickel‐Catalyzed Cycloisomerization of 1,6‐Dienes.
Authors: Boeing Christian , Hahne Julia , Francio Giancarlo , Leitner Walter
Published: September 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Direct Allylation of Aldimines Catalyzed by C2‐Symmetric N,N′‐Dioxide‐Sc(III) Complexes: Highly Enantioselective Synthesis of Homoallylic Amines.
Authors: Li Xing , Liu Xiaohua , Fu Yingzi , Wang Lijia , Zhou Lin , Feng Xiaoming
Published: September 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereoselective Synthesis of β,γ‐Unsaturated Ketones by Acid‐Mediated Julia‐Type Transformation from 2‐(1‐Hydroxyalkyl)‐1‐alkylcyclopropanols.
Authors: Nomura Kenichi , Matsubara Seijiro
Published: September 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Diastereo‐ and Enantioselective Synthesis of α‐Substituted syn‐α,β‐Diamino Acids.
Authors: Singh Anand , Johnston Jeffrey N.
Published: September 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Regioselective Markovnikov Hydrochalcogenation of Terminal Alkynes with Indium(III) Benzenechalcogenolates.
Authors: Peppe Clovis , de Castro Lierson Borges , Mello Melina de Azevedo , Barros Olga Soares do Rego
Published: September 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Arenium Cation as the Key Intermediate of the Electrosynthesis of N‐(2,5‐Dimethoxyphenyl)azoles. A New Approach to the Synthesis of N‐(Dimethoxyphenyl)azoles.
Authors: Petrosyan V. A. , Burasov A. V.
Published: September 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 2,5‐Dimethoxy‐2,5‐dihydrofuran Chemistry: A New Approach to 2(5H)‐Furanone Derivatives.
Authors: Garzelli R. , Samaritani S. , Malanga C.
Published: September 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Facile Formation of Tetrahydrofurans with Multiple Chiral Centers Using Double Iodoetherification of σ‐Symmetric Diene Acetals: Short Asymmetric Total Synthesis of Rubrenolide (VIII) and Rubrynolide (IX).
Authors: Fujioka Hiromichi , Ohba Yusuke , Hirose Hideki , Nakahara Kenji , Murai Kenichi , Kita Yasuyuki
Published: September 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Regioselective Reductive Opening of Substituted Phthalans: Synthetic Applications.
Authors: Garcia Daniel , Foubelo Francisco , Yus Miguel
Published: September 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 6‐Oxacyclopropa[a]indene Derivatives Starting from Baylis—Hillman Adducts via Pd‐Mediated C(sp3)—H Activation.
Authors: Kim Hoo Sook , Gowrisankar Saravanan , Kim Sung Hwan , Kim Jae Nyoung
Published: September 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Functionalized 5‐Oxo‐2,5‐dihydro‐1H‐pyrroles from Primary Alkylamines, Oxalyl Chloride, and Dimethyl Acetylenedicarboxylate.
Authors: Yavari Issa , Souri Sanaz
Published: September 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Polysubstituted Pyrroles from Sulfinimines (N‐Sulfinyl Imines).
Authors: Davis Franklin A. , Bowen Kerisha A. , Xu He , Velvadapu Venkata
Published: September 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereoselective Synthesis of 3‐Spiro‐α‐methylene‐γ‐butyrolactone Oxindoles from Morita—Baylis—Hillman Adducts of Isatin.
Authors: Shanmugam Ponnusamy , Vaithiyanathan Vadivel
Published: September 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Selective Reduction and Functionalization of Diethyl 1‐Alkyl‐1H‐indole‐2,3‐dicarboxylates.
Authors: Sayyed Iliyas Ali , Alex Karolin , Tillack Annegret , Schwarz Nicolle , Spannenberg Anke , Michalik Dirk , Beller Matthias
Published: September 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cyclization of Dialkylpropyn‐1‐yl(allyl)(3‐isopropenylpropyn‐2‐yl)ammonium Bromides and Water‐Base Cleavage of 2,2‐Dialkyl‐5‐methyl‐2,6,7,7a‐tetrahydro‐1H‐isoindolium and 2,2‐Dialkyl‐5‐methyl‐isoindolinium Bromide.
Authors: Chukhajian Emma H. , Nalbandyan Martiros K. , Gevorkyan Hasmik R. , Chukhajian Eliza H. , Panosyan Henrik A. , Ayvazyan Armen G. , Tamazyan Rafael A.
Published: September 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Boronic‐Acid Based Strategy to Synthesize 4(5)‐(Het)aryl‐1H‐imidazoles.
Authors: Primas Nicolas , Mahatsekake Clement , Bouillon Alexandre , Lancelot Jean‐Charles , Sopkova‐de Oliveira Santos Jana , Lohier Jean‐Francois , Rault Sylvain
Published: September 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ruthenium‐Catalyzed 1,3‐Dipolar Cycloaddition of Trifluoromethylated Propargylic Alcohols with Azides.
Authors: Zhang Chun‐Tao , Zhang Xingang , Qing Feng‐Ling
Published: September 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Dess—Martin Periodinane Promoted Oxidative Coupling of Baylis—Hillman Adducts with Silyl Enol Ethers: A Novel Synthesis of cis‐Fused Dihydropyrans.
Authors: Yadav J. S. , Reddy B. V. Subba , Mandal S. S. , Basak A. K. , Madavi C. , Kunwar A. C.
Published: September 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Proline‐Promoted Efficient Synthesis of 4‐Aryl‐3,4‐dihydro‐2H,5H‐pyrano[3,2‐c]chromene‐2,5‐diones in Aqueous Media.
Authors: Yavari Issa , Sabbaghan Maryam , Hossaini Zinatossadat
Published: September 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: One‐Pot Synthesis of Angular Furocoumarins: A Simple Protocol Involving Unprecedented Intramolecular Aldol Condensation.
Authors: Dutta Lakshmi Narayan , De Banani , Patra Amarendra
Published: September 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Dipyridine Cobalt Chloride: A Novel Catalyst for the Synthesis of Coumarins via Pechmann Condensation.
Authors: Madhav Janganati Venu , Kuarm Bowroju Suresh , Someshwar Pola , Rajitha Bavanthula , Reddy Yerram Reddy Thirupathi , Crooks Peter A.
Published: September 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Hydrogenation of Quinolines Catalyzed by Iridium Complexes of Monodentate BINOL‐Derived Phosphoramidites.
Authors: Mrsic Natasa , Lefort Laurent , Boogers Jeroen A. F. , Minnaard Adriaan J. , Feringa Ben L. , de Vries Johannes G.
Published: September 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Isoquinoline‐3‐carboxylates and Benzocyclobutanes via Reaction of 2‐Amidoacrylate Esters with Arynes.
Authors: Blackburn Tom , Ramtohul Yeeman K.
Published: September 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.