bluuebunny/crossref_metadata_2025 huggingface dataset:
Aproximación al sentido de digitalidad desde la hermenéutica de generalidad superior de Gadamer
Authors: Pérez-Baena Flavio Antonio
Published: May 2020

La digitalidad es un aspecto de la tecnología que ha venido transformando las formas de relación del hombre con el mundo y las nuevas tecnologías. En esta perspectiva se plantea un problema en tanto que el hombre se enajena y pierde el sentido de su existencia. Por ello, el texto presenta una reflexión en torno a la búsqueda del sentido de la digitalidad, como una herramienta que sirve al ser humano. Esto se propone desde el desarrollo de la generalidad superior planteada en la hermenéutica desarrollada por Gadamer. El texto se plantea como un avance en la búsqueda del sentido en la era digital, que le permita al hombre asumir sus cualidades, desde la metodología de la interpretación que plantea la hermenéutica, y descubra el propósito de la vida con la intervención de los medios digitales. Cuando se identifica el sentido de la digitalidad, se reconocen las maneras de relacionarse entre el hombre y los sistemas digitales y las posibles influencias que las diferentes concepciones pueden ejercer sobre el ser humano. Ello permitirá que el hombre pueda buscar el sentido trascendente de su existencia.
Apropiación social del conocimiento científico y tecnológico. Un legado de sentidos
Authors: Dávila-Rodríguez Lisha Pamela
Published: May 2020

La apropiación social como un concepto que construye sentido en teorías, paradigmas y grandes relatos posibilita observar cómo se utiliza el término como motor de procesos particulares desde la filosofía hegeliana, la psicología, la literatura, el arte y hasta en el campo de las tecnologías de información y comunicación. Este trabajo revisa cómo estas significaciones repercuten cuando se las relaciona también con la ciencia y la tecnología. Esta variabilidad de significados hace posible una interpretación del legado de sentidos del término, a partir de la cual surge una propuesta conceptual para entender la apropiación social del conocimiento, científico y tecnológico, y su potencialidad de acción, como un factor emancipador del dominio, las asimetrías y desigualdades que marcan ciertos sistemas dominantes como el capitalismo cognitivo.
Influencia de procesos de ludificación en entornos de aprendizaje STEM para alumnos de Educación Superior
Authors: Calvo Luis Fernando , Herrero Martínez Raúl , Paniagua Bermejo Sergio
Published: May 2020

Los alumnos de ciencias, tecnología e ingeniería, en el ámbito del Espacio Europeo de Educación Superior, suelen abordar sus asignaturas como parcelas de conocimiento debido a la propia construcción de los planes docentes y la estructura interdepartamental de las universidades. es decir, sin que se profundice en la interrelación entre esas parcelas y la futura realidad laboral que el estudiante tendrá que vivir. Durante esta investigación se diseñó un juego de mesa, desde el marco de referencia de educación STEAM (Science, Technology, Engineering, Arts and Mathematics), con la finalidad de establecer dinámicas propias de las actividades lúdicas para generar un entorno de aprendizaje ludificado. Mediante un proceso de investigación planificado, organizado, dirigido y sistemático se valoró el efecto que tiene la utilización del juego de mesa sobre las calificaciones académicas del alumnado de ingeniería, partiendo de la hipótesis de que la utilización de este juego permite adquirir no solo conocimientos, sino también la capacidad de integrar los conocimientos de las asignaturas directamente vinculadas al entorno STEAM. El análisis de los resultados verificó la hipótesis de partida de esta investigación, confirmando el efecto positivo que tiene el uso de elementos de ludificación en entornos STEAM.
Hvordan bruke pusten som verktøy for å prestere på sitt beste
Authors: Mathias Johan Matland
Published: May 2020

Masterprosjekt. Basert på forskning, undersøkes det hvordan pusten kan brukes som verktøy for å prestere på sitt beste. Det presenteres en metode som tilbyr et godt grunnlag for å uttrykke seg musikalsk, i tillegg til å skape en følelse av ro, tilstedeværelse og å bygge mental styrke.
Genus Humidophila from caves in Serbia with an improved detailed description of rare H. brekkaensoides
Authors: Nikolic Natasa , Popovic Sladjana , Vidakovic Danijela , Subakov-Simic Gordana , Krizmanic Jelena
Published: May 2020

Phototrophic microorganisms can be found in biofilms at entrances to caves where they have access to sufficient sunlight, water and nutrients; however, they can also be found inside caves, where they are carried by animals and people, and can proliferate in the presence of artificial light. Although the genus Humidophila includes some well-known cosmopolitan species, further exploration of its rare, insufficiently investigated representatives in different geographical areas and unusual habitats is necessary. Caves remain unknown, little-explored habitats, and many species currently known to science were recorded for the first time. This study aimed to report species belonging to the genus Humidophila that were identified in 19 caves in Serbia. A total of ten species of this genus were recorded and some of them are documented for the first time in Serbia. The most abundant species were H. contenta (found in 16 caves), H. paracontenta, and H. aerophila (found in 13 caves), whereas H. pyrenaica was identified in only one cave. The rare species, H. brekkaensoides and H. vidalii, were also documented and described, but with different dimensions from those provided in current identification keys.
Excessive Glucocorticoids During Pregnancy Impair Fetal Brown Fat Development and Predispose Offspring to Metabolic Dysfunctions
Authors: Chen Yan-Ting , Hu Yun , Yang Qi-Yuan , Son Jun Seok , Liu Xiang-Dong , de Avila Jeanene M. , Zhu Mei-Jun , Du Min
Published: May 2020

Maternal stress during pregnancy exposes fetuses to hyperglucocorticoids, which increases the risk of metabolic dysfunctions in offspring. Despite being a key tissue for maintaining metabolic health, the impacts of maternal excessive glucocorticoids (GC) on fetal brown adipose tissue (BAT) development and its long-term thermogenesis and energy expenditure remain unexamined. For testing, pregnant mice were administered dexamethasone (DEX), a synthetic GC, in the last trimester of gestation, when BAT development is the most active. DEX offspring had glucose, insulin resistance, and adiposity and also displayed cold sensitivity following cold exposure. In BAT of DEX offspring, Ppargc1a expression was suppressed, together with reduced mitochondrial density, and the brown progenitor cells sorted from offspring BAT demonstrated attenuated brown adipogenic capacity. Increased DNA methylation in Ppargc1a promoter had a fetal origin; elevated DNA methylation was also detected in neonatal BAT and brown progenitors. Mechanistically, fetal GC exposure increased GC receptor/DNMT3b complex in binding to the Ppargc1a promoter, potentially driving its de novo DNA methylation and transcriptional silencing, which impaired fetal BAT development. In summary, maternal GC exposure during pregnancy increases DNA methylation in the Ppargc1a promoter, which epigenetically impairs BAT thermogenesis and energy expenditure, predisposing offspring to metabolic dysfunctions.
Issues of Cardiovascular Risk Management in People With Diabetes in the COVID-19 Era
Authors: Ceriello Antonio , Standl Eberhard , Catrinoiu Doina , Itzhak Baruch , Lalic Nebojsa M. , Rahelic Dario , Schnell Oliver , Škrha Jan , Valensi Paul
Published: May 2020

People with diabetes compared with people without exhibit worse prognosis if affected by coronavirus disease 2019 (COVID-19) induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), particularly when compromising metabolic control and concomitant cardiovascular disorders are present. This Perspective seeks to explore newly occurring cardio-renal-pulmonary organ damage induced or aggravated by the disease process of COVID-19 and its implications for the cardiovascular risk management of people with diabetes, especially taking into account potential interactions with mechanisms of cellular intrusion of SARS-CoV-2. Severe infection with SARS-CoV-2 can precipitate myocardial infarction, myocarditis, heart failure, and arrhythmias as well as an acute respiratory distress syndrome and renal failure. They may evolve along with multiorgan failure directly due to SARS-CoV-2–infected endothelial cells and resulting endotheliitis. This complex pathology may bear challenges for the use of most diabetes medications in terms of emerging contraindications that need close monitoring of all people with diabetes diagnosed with SARS-CoV-2 infection. Whenever possible, continuous glucose monitoring should be implemented to ensure stable metabolic compensation. Patients in the intensive care unit requiring therapy for glycemic control should be handled solely by intravenous insulin using exact dosing with a perfusion device. Although not only ACE inhibitors and angiotensin 2 receptor blockers but also SGLT2 inhibitors, GLP-1 receptor agonists, pioglitazone, and probably insulin seem to increase the number of ACE2 receptors on the cells utilized by SARS-CoV-2 for penetration, no evidence presently exists that shows this might be harmful in terms of acquiring or worsening COVID-19. In conclusion, COVID-19 and related cardio-renal-pulmonary damage can profoundly affect cardiovascular risk management of people with diabetes.
Dødshjelp: Lovverk, praksis og holdninger i de skandinaviske land
Authors: Kleiven Daniel Joachim H. , Hartling Ole , Ståhle Fabian , Horn Morten A. , Magelssen Morten
Published: May 2020

Why a book on assisted dying in the Nordic countries? The Nordic countries share many similarities, both culturally and in terms of their legal systems, and we have much to learn from each other. In this chapter, we briefly describe legislation and practices with assisted dying in the three Scandinavian countries. Denmark, Norway and Sweden are characterised by restrictive assisted dying legislation. As expressed in surveys, the majority of their general populations seems to support legalisation of assisted dying, while health professionals and politicians are more negative to legalisation. This interesting disparity and its implications are discussed at the end of the chapter.
“Minha língua, minha história, meu processo de escolarização”: narrativas de si de docentes surdos
Authors: Da Rocha Simone Maria , Fagundes Isabelle Pinheiro
Published: May 2020

Quais experiências marcaram os professores surdos em suas trajetórias de escolarização na Educação Básica e no Ensino Superior? Como suas narrativas, suas histórias de vida, podem nos ajudar a pensar a formação docente e a pesquisa em ensino e educação? Este artigo tem por objetivo primordial apresentar as narrativas (auto)biográficas como método de investigação com professores surdos. Encontramos nas entrevistas narrativas um caminho metodológico para a recolha e análise das narrativas de si sinalizadas. Participaram da pesquisa cinco professores surdos do curso de Letras Libras de uma universidade federal, no interior do Brasil. Dos achados, destacamos as narrativas sobre a Educação Básica que apontam dificuldades enfrentadas pelos surdos, traduzidas por exclusões, silenciamentos e apatia pedagógica; contrariamente, no Ensino Superior, as narrativas demonstram que a universidade foi um espaço no qual os professores surdos se identificaram com a construção do conhecimento, que se descobriram e desenvolveram projetos e projeções de si.
A questão do bilinguismo. Uma discussão teórica sobre os conceitos de bi, multi e plurilinguismo na Educação para Surdos
Authors: Härter Larissa Ruth Siniak dos Anjos , Borges Flávia Girardo Botelho
Published: May 2020

Este artigo tem por objetivo discutir os conceitos de aquisição de segunda língua, bilinguismo, multilinguismo e plurilinguismo na Educação para Surdos, tendo como referencial teórico os autores De Angelis (2007), Pinto (2013), Scarpa (2001), Campos (2012), Grosjean (1992) e Cavalli et al. (2009). A questão fundamental foi entender se o CEAADA, instituição pública?Privada? de ensino de Cuiabá, capital de Mato Grosso, que tem como primazia atender a um público com deficiência auditiva, múltiplas deficiências e também alunos surdo-cegos, é ou não uma escola bilíngue, conforme é apresentado nos documentos oficiais, a exemplo do Projeto Político Pedagógico: “Por ser uma escola de educação bilíngue, sendo a Língua Portuguesa a segunda língua e a LIBRAS, a primeira língua, a língua de instrução será a Língua Brasileira de Sinais” (PPP CEAADA, 2016, p. 91). Como resultado, não concebemos que plurilinguismo ou monolinguismo sejam adequados à realidade do e no CEAADA e que o termo e o conceito teórico/prático de bilinguismo seja o que melhor se enquadra à realidade analisada e vivenciada nessa escola. O artigo ainda abre a discussão para um acompanhamento prático do conceito de bilinguismo.
Apresentação Volume Temático II Bilinguismo para surdos: Um olhar histórico, social, educacional e linguístico
Authors: Silva Kleber Aparecido da , Guedes Sônia Margarida Ribeiros , Dias Tatiana Rosa Nogueira , Tuxi Patrícia , Tanzi Neto Adolfo
Published: May 2020

O segundo volume  do dossiê temático: Bilinguismo para surdos: um olhar histórico, social, educacional e linguístico da Revista The Especialist é uma nova possibilidade para leituras de grande importância na área do Bilinguismo das línguas de sinais. Por meio desse número é possível compreender a vastidão que esse conceito hoje abarca nas mais diversas áreas do conhecimento e como ainda há muito a ser explorado, como os próprios autores afirmam. Apesar de ser uma coletânea escrita por várias mãos apresenta,  na verdade,  um único objetivo: oportunizar a leitura de novos autores e suas respectivas pesquisas que trazem um olhar contemporâneo sobre o bilinguismo no universo das línguas de sinais (GESSER, 2009; QUADRO, 2019).
Desdobramentos da organização curricular linguística de uma escola bilíngue para surdos no Distrito Federal
Authors: Bueno Milene Galvão , Silva Kleber Aparecido da
Published: May 2020

A educação bilíngue para surdos vem conquistando as atenções públicas, políticas e educacionais no Brasil atualmente. Marcos históricos na educação de surdos revelam os rumos que esse modelo educacional está tomando. A exemplo disso,  temos políticas linguísticas como a Lei da Libras nº 10.436/02 e o Decreto nº 5.626/05, que foram criadas com o intuito de nortear caminhos para um possível bilinguismo para surdos. Posto isso, como aporte metodológico da análise documental à luz da Linguística Aplicada Crítica (LAC), este artigo trata criticamente do perfil institucional e da organização linguística do currículo de acordo com o Projeto Político-Pedagógico da Escola Bilíngue de Libras e Português Escrito, em Brasília,  evidenciando, assim, que um modelo de educação bilíngue para surdos deva compreender bem mais do que uma adaptação curricular. Para além disso,  que seja pensado e adequado para e por surdos.
PENGUATAN KELEMBAGAAN RUKUN TETANGGA DAN RUKUN WARGA (RT/RW) DI KELURAHAN RINTIS KECAMATAN LIMA PULUH KOTA PEKAN BARU
Authors: Zuhdi Sulaiman , Ferizko Adia , Melinda Pebriana
Published: May 2020

PENGUATAN KELEMBAGAAN RUKUN TETANGGA DAN RUKUN WARGA (RT/RW) DI KELURAHAN RINTIS KECAMATAN LIMA PULUH KOTA PEKANBARU Salah satu mitra pemerintah kelurahan adalah organisasi Rukun Tetangga (RT) dan Rukun Warga (RW). RT/RW mempunyai fungsi sebagai pengkoordinasi antar warga, jembatan aspirasi antar sesama masyarakat dengan pemerintah daerah, menjadi penengah penyelesaian masalah-masalah kemasyarakatan yang dihadapi warga, sedangkan tugas-tugasnya antara lain membantu menjalankan tugas pelayanan kepada masyarakat yang menjadi tanggung jawab pemerintah kota, memelihara kerukunan hidup warga, menyusun rencana dan melaksanakan pembangunan dengan mengembangkan aspirasi dan swadaya murni masyarakat.Dari tugas dan fungsi RT/RW diatas dapat diketahui amatlah vital. RT/RW adalah lembaga kemasyarakatan yang berhubungan langsung dengan masyarakat, mereka adalah mulut dan telinga pemerintah yang memiliki fungsi sebagai penyampai kebijakan-kebijakan pemerintah dan sebagai penerima aspirasi pertama masyarakat.Pemerintah  Daerah Kota Pekanbaru  telah  mengeluarkan Peraturan Daerah Kota Nomor 12 Tahun 2002 tentang RT/RW. Namun jika dilihat dari keberadaan kelembagaan RT/RW di kelurahan Rintis  dalam  menjalankan tugas dan fungsinya belum maksimal. Indikator yang terlihat adalah belum sepenuhnya ketua RT/RW mengetahui dan memahami akan tugas, fungsi dan tanggungjawabnya, struktur organisasi RT/RW yang belum berfungsi dengan baik, kurangnya koordinasi dan kerjasama pengurus RT/RW dan pemerintah kelurahan serta kurangnya pembinaan dari pemerintah seperti pelatihan yang berhubungan dengan birokrasi, tata kelola dan administrasi pemerintahan.  Dengan kondisi yang demikian sangat berpengaruh terhadap kinerja kelembagaan RT/RW. Kata Kunci : Penguatan, Kelembagaan, Pemerintah, RT/RW
Analysis of Mobile App Revenue Models Used in the most Popular Games of the Tower Defense Genre on Google Play
Authors: Groeschel Michael , SchÃ¤fer Tim
Published: May 2020

This paper analyzes the revenue models of the most popular games of the Tower Defense genre on Google Play. A special look is taken at the quantitative distribution of the app sale model and the free model in terms of quality and download numbers. Additionally, this paper considers the qualitative implementation of the â€œfreeâ€ model in the most popular games. First, the usual revenue models of mobile apps will be discussed and then the Tower Defense genre will be explained. Following that, the quantitative distribution of revenue models and an analysis of the most popular appsâ€™ respective revenue models will be addressed. The analysis also identifies and explains two modifications of established revenue models. The most popular revenue model for mobile apps in the Tower Defense genre are in-app purchases. This distinguishes the genre from many other genres and games. A wide range of Tower Defense games utilizes the revenue models app sale and free. It becomes apparent that revenue models for mobile apps must be analyzed and considered specifically for their respective sector, and that no single promising revenue model for apps exists.
Espaço público de propriedade privada em Curitiba (Brasil): o Boulevard da Neo Superquadra | Privately ownead public space in Curitiba (Brazil): the Neo Superquadra Boulevard
Authors: Meiners Wilhelm Eduard Milward de Azevedo , Garbossa Silva Renata Adriana , Rosaneli Alessandro Filla
Published: May 2020

O espaço público contemporâneo assume diferentes formas, usos e domínios, importando hoje mais sua apropriação do que sua propriedade. Em oposição ao espaço público tradicional, surgem novos espaços que mesclam o público e o privado. Para perceber as formas que o espaço público assume na contemporaneidade, destaca-se um espaço de fruição pública e de propriedade privada, localizado no Centro Cívico, bairro de Curitiba (Brasil) que representa a reconquista da significação do espaço público para expressão da cidadania e manifestação política. O espaço analisado é um pequeno boulevard de passagem e conexão junto ao empreendimento imobiliário da Neo Superquadra, um conjunto de torres de uso misto — comercial, corporativo e residencial interligando importantes vias locais. O artigo elabora, nos limites de uma pesquisa realizada em um espaço público de propriedade privada, com o método da trialética lefebvriana, as análises da dimensão simbólica do espaço concebido, da dimensão física e sensorial do espaço percebido e da dimensão social do espaço vivido, conformando uma crítica aos espaços públicos contemporâneos, de subsunção das coisas públicas aos interesses privados.
PENGUNGKAPAN PERTANGGUNGJAWABAN KEUANGAN PARTAI POLITIK
Authors: Andini Isnani Yuli , Arfiyanto Dedy
Published: May 2020

Political parties are required to make improvements in building transparency and accountability. Developing political ethics in financial management that stands on the values ​​of accountability and transparency. The purpose of this study is to determine the party's financial governance including disclosure of financial accountability. Research results obtained regarding the accountability and financial transparency of the Gerindra party began to apply according to standards. Gerindra party financial management has also begun to be accessed by all parties through the party's official website, so that in 2014 the Gerindra party was named the Public Information Category for Political Parties by the Central Information Commission (KIP) as well as the results of the Indonesia Survey Center (ISC) survey which states that Gerindra is a party which is perceived as clean of corruption cases. With this title the Gerindra Party became the political party that won the third most national votes in the 2019 general election.
Efeitos da música clássica aplicada em crianças hospitalizadas
Authors: Silva Ana Célia Pereira da , Oliveira Marcelo Lima de , Carvalho Leonardo Cesar , Lima Ciderleia Castro de
Published: May 2020

Objetivo: Verificar os efeitos da música clássica em crianças hospitalizadas em Unidade de Terapia Intensiva e Enfermaria de Pediatria. Métodos: É um estudo quase experimental, abordagem quantitativa. Participaram quatro crianças menores de 36 meses, expostas a 40 minutos diários por cinco dias ao repertório Mozart baby, respeitando a altura de som de 45 decibéis (dB). Utilizou um formulário estruturado para registros de frequência cardíaca, frequência respiratória, saturação, temperatura, escala de dor. Os critérios de inclusão foram a exposição a procedimentos invasivos nas últimas seis horas, frequência inspiratória de oxigênio (FiO2) menor ou igual a 21% e ventilação não assistida. Aplicado no músculo bíceps braquial um eletrodo e analisado a tensão muscular no primeiro e quinto dia. O registro feito pelo eletromiografo Trigno 8 Channel Wireless. A exposição ao estresse foi avaliado pela saliva em fita teste no primeiro e quinto dia, no aparelho Coroco Meter (Nipro Corporation – Japão). Resultados: Houve redução nos valores hemodinâmicos com p-valor menor que 0,01, a dor com p-valor menor que 0,001.  A eletromiografia verificou redução dos impulsos elétricos influenciando na taxa do disparo para as fibras musculares com relaxamento muscular. Conclusão: A música estimula diferentes áreas cerebrais e pode ser utilizada para auxiliar segmentos terapêuticos.
In Silico Exploration of Repurposing and Optimizing Traditional Chinese Medicine Rutin for Possibly Inhibiting SARS-CoV-2's Main Protease
Authors: Huynh Tien , Wang Haoran , Cornell Wendy , Luan Binquan
Published: May 2020

Coronavirus disease 2019 (COVID-19) is an ongoing global pandemic with very limited specific treatments. To fight COVID-19, various traditional antiviral medicines haveb been prescribed in China to infected patients with mild to moderate symptoms and received unexpected success in controlling the disease. However, the molecular mechanisms of how these herbal medicines interact with the virus have remained elusive. It is well known that the main protease (Mpro) of SARS-CoV-2 plays an important role in maturation of many viral proteins such as the RNA-dependent RNA polymerase. Here,we explore the underlying molecular mechanisms of the computationally determined top candidate–rutin, a key component in many traditional antiviral medicines such as Lianhuaqinwen and Shuanghuanlian, for inhibiting the viral target–Mpro. Using in silico methods (docking and molecular dynamics simulations), we revealed the dynamics and energetics of rutin when interacting with the Mpro of SARS-CoV-2, suggesting that the highly hydrophilic rutin molecule can be bound inside the Mpro’ pocket (active site) and possibly inhibit its biological functions. In addition, we optimized the structure of rutin and designed a more hydrophobic analog which satisfies the rule of five for western medicines and demonstrated that it possesses a much stronger binding affinity to the SARS-COV-2’s Mpro.
Pharmaceutical Targeting the Envelope Protein of SARS-CoV-2: the Screening for Inhibitors in Approved Drugs
Authors: Chernyshev Anatoly
Published: May 2020

An essential overview of the biological role of coronavirus viroporin (envelope protein) is given, together with the effect of its known inhibitors on the life cycle of coronavirus. A docking study is conducted using a set of known drugs approved worldwide (ca. 6000 compounds) on a structure of the SARS-CoV-2 viroporin modelled from the published NMR-resolved structures. The screening has identified 36 promising drugs currently on the market, which could be proposed for pre-clinical trials.
Helium Nanodroplet Isolation Spectroscopy in an Undergraduate Teaching Laboratory
Authors: Raston Paul
Published: May 2020

A home-built helium nanodroplet isolation spectrometer has been utilized byundergraduate students in course-based experiments to investigate the rovibrational dynamicsof small molecules. Helium nanodroplets are well known to simplify the spectroscopy ofembedded molecules owing to their low temperature (0.4 K) and weakly interacting nature.In the infrared spectral region, this results in a small number of rotationally resolved lines thatcan often be collected and analyzed in several lab periods. We demonstrate the advantages ofusing this technique in an upper-level undergraduate chemistry course for which the laserspectroscopy of helium solvated 13C-labelled formic acid was investigated for the first time.
Glycosidic C-O Bond Activation in Cellulose Pyrolysis: Alpha Versus Beta and Condensed Phase Hydroxyl-Catalytic Scission
Authors: Dauenhauer Paul , Maliekkal Vineet , Neurock Matthew
Published: May 2020

Mechanistic insights into glycosidic bond activation in cellulose pyrolysis were obtained via first principles density functional theory calculations that explain the peculiar similarity in kinetics for different stereochemical glycosidic bonds (β vs α) and establish the role of the three-dimensional hydroxyl environment around the reaction center in activation dynamics. The reported activating mechanism of the α-isomer was shown to require an initial formation of a transient C1-O2-C2 epoxide, that subsequently undergoes transformation to levoglucosan. Density functional theory results from maltose, a model compound for the α-isomer, show that the intramolecular C2 hydroxyl group favorably interacts with lone pair electrons on the ether oxygen atom of an α-glycosidic bond in a manner similar to the hydroxymethyl (C6 hydroxyl) group interacting with the lone pair electrons on the ether oxygen atom of a β glycosidic bond. This mechanism has an activation energy of 52.4 kcal/mol, which is similar to the barriers reported for non-catalytic transglycosylation mechanism (~50 kcal/mol). Subsequent constrained ab initio molecular dynamics (AIMD) simulations revealed that vicinal hydroxyl groups in the condensed environment of a reacting carbohydrate melt anchor transition states via two-to-three hydrogen bonds and lead to lower free energy barriers (~32-37 kcal mol-1) in agreement with previous experiments.
Structure Based Drug Repurposing Through Targeting Nsp9 Replicase and Spike Proteins of SARS-CoV-2
Authors: Chandel Vaishali , Sharma Prem Prakash , Raj Sibin , Rathi Brijesh , Kumar Dhruv
Published: May 2020

Due to unavailability of therapeutic approach for the novel coronavirus disease (COVID-19), the drug repurposing approach would be the fastest and efficient way of drug development against this deadly disease. We have applied bioinformatics approach for structure-based drug repurposing to identify the potential inhibitors through drug screening, molecular docking and molecular dynamics against non-structural protein 9 (Nsp9) replicase and spike proteins of the SARS-CoV-2 from the FDA approved drugs. We have performed virtual screening of 2000 FDA approved compounds including antiviral, anti-malarial, anti-parasitic, anti-fungal, anti-tuberculosis and active phytochemicals against Nsp9 replicase and spike proteins of SARS-CoV-2. Molecular docking was performed using Autodock-Vina. Selected hit compounds were identified based on their highest binding energy and favourable ADME profile. Notably, Conivaptan, an arginine vasopressin antagonist drug exhibited highest binding energy (-8.4 Kcal/mol) and maximum stability with the amino acid residues present on the active site of Nsp9 replicase. Additionally, Tegobuvir, a non-nucleoside inhibitor of hepatitis C virus exhibited maximum stability with highest binding energy (-8.1 Kcal/mol) on the active site of spike protein. Molecular docking scores were further validated with the molecular dynamics using Schrodinger, which supported strong stability of ligands with proteins at their active site through water bridges, hydrophobic interactions, H-bond. Overall, our findings highlight the fact that Conivaptan and Tegobuvir could be used to control the infection and propagation of SARS-CoV-2 targeting Nsp9 replicase and spike protein, respectively. Moreover, in vitro and in vivo validation of these findings will be helpful in bringing these molecules at the clinical settings.
Scaffold Diversity for Enhanced Activity of Glycosylated Inhibitors of Fungal Adhesion
Authors: Krämer Tobias , kavanagh kevin , Velasco-Torrijos Trinidad , Martin Harlei , Somers Tara , Pfeiffer Fred , Robson Ryan , Dwyer Mathew
Published: May 2020

Candida albicans is one of the most prevalent fungal pathogens involved inhospital acquired infections. It uses adhesins to bind to glycans at the cell surface of epithelialcells and thus initiate infection. These interactions can be blocked by synthetic carbohydrates(such as compound 1) that mimics the structure of cell surface glycans. Herein we report thesynthesis of a new series of divalent galactosides featuring aromatic (benzene, squaramides)and aliphatic (norbornenes) central scaffolds, with the latter being the first examples of theirkind as small molecule anti-adhesion glycoconjugates. The evaluation of these compounds asinhibitors of adhesion of C. albicans o exfoliated buccal epithelial cells (BECs) revealed thatgalactosides 1 and 6, built on an aromatic core, were the most efficient inhibitors of adhesion,displacing up to 36% and 48%, respectively, of yeast cells already attached to the BECs at0.138 μM. Conformational analysis of compound 1 identified the preference for a folded presentation in the lowest energy conformers. Remarkably, cis-endo-norbornene 21 performedcomparably to the benzene-core derivatives, highlighting the potential of norbornenes as a newclass of aliphatic scaffolds for the synthesis of anti-adhesion compounds.
Understanding COVID-19 – The Pandemic of 2020
Authors: Prasaath Sastha K R  , Balasubramanian Arul  , Ramalingam Kothai
Published: May 2020

It all started in December 2019, a seafood market in Wuhan, China, with a series of pneumonia alike cases admitted with severe acute respiratory depression. Since they were unable to detect the precise cause, they named it "Pneumonia of unknown etiology". Later it was identified as SARS COV 2 (Severe Acute Respiratory Syndrome – coronavirus 2). At first, the disease spread locally affecting the people of Wuhan, and then started spreading throughout China, creating a worldwide panic. The World Health Organization (WHO) declared COVID-19 in China as a Public Health Emergency of International Concern. The Center for Disease Control and Prevention (CDC) from China and local healthcare units organized an intensive outbreak investigation program. The causative organism of this infection is a new virus that belongs to the “coronavirus (CoV)” family. After which the disease was called nCoV-19 (Novel coronavirus – 19). On February 11, 2020, the WHO Director General, Dr. Tedros Adhanom Ghebreyesus, renamed the disease as "COVID-19," which is the acronym of "coronavirus disease 2019". Viral epidemics like SARS-CoV in 2002, H1N1 influenza in 2009, and the most recent one the MERS-CoV Middle East Respiratory Distress Syndrome Coronavirus (first identified in Saudi Arabia) in 2012 threatened the health of mankind in the past two decades. All of these were successfully prevented by systematically approaching the problem to solve it. Healthcare professionals around the world are well trained to manage any type of health crisis. On March 11, 2020, the WHO declared COVID-19 as a "PANDEMIC" pointing to over 118,000 cases and 80,000 dead in 110 countries or more. In a media briefing, the WHO Director General said: "This is not just a public health crisis, it is a crisis that will touch every sector, so every sector and every individual must be involved in the fight."
STRENGTHENING THE LAW IN ORDER TO KEEP EXISTENCE THE UNITARY STATE OF THE REPUBLIC OF INDONESIA
Authors: Suharto Rokhmat Bowo
Published: May 2020

The Unitary State of the Republic of Indonesia (NKRI) was founded on the support of diversity, both ethnicity, religion, and customs. As historical, the building of such a nation could not be separated from the various tests, beginning of rebellions based on ethnicity, religion, and political ideology, to replace the form of a union state with the enactment of the Constitution. RIS has also occurred. In fact, the Republic of Indonesia remained standing up to this moment. As a law that addresses the entire existing local legal system, the Indonesian legal system has actually placed various means integration which is at the same time the national identity of the Republic of Indonesia building. Associated with the goal of the existence of the Republic of Indonesia, the existing legal construction needs to be strengthened by conducting a paradigmatic evaluation that is continuous and continuous related to (1) legal pluralism policy; (2) legalistic legal paradigm; (3) Central and Regional Relations and local communities; (4) Cultivation of cultural aspects and social capital in development policies; (5) the division of public and private space related to the expression of differences between various cultural, religious or ethnic communities; and (6) Liberalization of political life.
PROFESSIONAL ETHICS AND LEGAL PROTECTION FOR NOTARY
Authors: Soegianto Soegianto
Published: May 2020

Notary is a profession that is authorized to make authentic deeds about all deeds, agreements and stipulations required by a general regulation or by the interested parties to be stated in an authentic deed, guarantee the certainty of the date, keep the deed and give the grosse, copies and quotations. Basing on the moral and ethical values of the Notary, carrying out the position of the Notary Public is a service to the community (client) independently and not taking sides in the field of notary, whose service is lived as a vocation based on the spirit of devotion to fellow human beings for the public interest and rooted in respect for dignity humans in general and notary dignity in general. In exercising its authority as a Public Official who makes an authentic deed, the Notary Public must uphold the Notary Ethics Code and be protected by Act Number 2 of 2014 amending the Law Number 30 of 2004 concerning the Position of Notary.
JURIDIC ANALYSIS OF USED CLOTHES CONSUMER BASED ON ARTICLE 4 CONSUMER PROTECTION AND ISLAMIC LAW PERSPECTIVE
Authors: Sugiharto Sugiharto , Ilmih Andi Aina
Published: May 2020

This research focuses on the form of legal protection for used clothing consumers based on Article 4 of Law Number 8 of 1999 concerning consumer protection and analyzes the impact of the use of used clothing by the community in the city of Semarang, related to the Thaharah aspects in Islamic Law.To achieve this goal, researchers used a sociological juridical approach with data collection techniques in the form of library research and field studies by conducting direct interviews with relevant parties in connection with this research. The data obtained were then processed and analyzed by descriptive qualitative.The results showed that the form of legal protection for used clothing consumers in the Consumer Protection Act under Article 4, namely the right of consumers to get comfort, security, and safety. This is closely related to the obligations of business actors in providing true, clear and honest information about the conditions and guarantees of goods and/or services; and the need for guidance and supervision by the government. The impact caused by used clothing is negative impact and positive impact for used clothing consumers, both in terms of economic, social and public health in Indonesia. Although in an Islamic perspective, it is recommended that people prioritize aspects of thaharah (cleanliness) as Allah SWT requires every Muslim to purify in accordance with the criteria of Allah and His Prophet.
High-dose influenza vaccination and mortality among predominantly male, white, senior veterans, United States, 2012/13 to 2014/15
Authors: Young-Xu Yinong , Thornton Snider Julia , Mahmud Salaheddin M , Russo Ellyn M , Van Aalst Robertus , Thommes Edward W , Lee Jason KH , Chit Ayman
Published: May 2020

Introduction

It is unclear whether high-dose influenza vaccine (HD) is more effective at reducing mortality among seniors.

Aim

This study aimed to evaluate the relative vaccine effectiveness (rVE) of HD.

Methods

We linked electronic medical record databases in the Veterans Health Administration (VHA) and Medicare administrative files to examine the rVE of HD vs standard-dose influenza vaccines (SD) in preventing influenza/pneumonia-associated and cardiorespiratory mortality among VHA-enrolled veterans 65 years or older during the 2012/13, 2013/14 and 2014/15 influenza seasons. A multivariable Cox proportional hazards model was performed on matched recipients of HD vs SD, based on vaccination time, location, age, sex, ethnicity and VHA priority level.

Results

Among 569,552 person-seasons of observation, 207,574 (36%) were HD recipients and 361,978 (64%) were SD recipients, predominantly male (99%) and white (82%). Pooling findings from all three seasons, the adjusted rVE estimate of HD vs SD during the high influenza periods was 42% (95% confidence interval (CI): 24–59) against influenza/pneumonia-associated mortality and 27% (95% CI: 23–32) against cardiorespiratory mortality. Residual confounding was evident in both early and late influenza periods despite matching and multivariable adjustment. Excluding individuals with high 1-year predicted mortality at baseline reduced the residual confounding and yielded rVE of 36% (95% CI: 10–62) and 25% (95% CI: 12–38) against influenza/pneumonia-associated and cardiorespiratory mortality, respectively. These were confirmed by results from two-stage residual inclusion estimations.

Discussion

The HD was associated with a lower risk of influenza/pneumonia-associated and cardiorespiratory death in men during the high influenza period.
Early impact of the coronavirus disease (COVID-19) pandemic and physical distancing measures on routine childhood vaccinations in England, January to April 2020
Authors: McDonald Helen I , Tessier Elise , White Joanne M , Woodruff Matthew , Knowles Charlotte , Bates Chris , Parry John , Walker Jemma L , Scott J Anthony , Smeeth Liam , Yarwood Joanne , Ramsay Mary , Edelstein Michael
Published: May 2020

Using electronic health records, we assessed the early impact of coronavirus disease (COVID-19) on routine childhood vaccination in England by 26 April 2020. Measles-mumps-rubella vaccination counts fell from February 2020, and in the 3 weeks after introduction of physical distancing measures were 19.8% lower (95% confidence interval: −20.7 to −18.9) than the same period in 2019, before improving in mid-April. A gradual decline in hexavalent vaccination counts throughout 2020 was not accentuated by physical distancing.
Board characteristics and cost of debt: Evidence from Indonesia
Authors: Stefany Stefany , Joni Joni
Published: May 2020

Corporate governance has been an important issue for investors, practitioners, and regulators. This is because board characteristic as central feature of corporate governance has a significant impact on the economy and the firm’s operation. This study investigates the effect of board characteristics on cost of debt for the Indonesian listed companies for the period 2016-2017. The final sample of this study is 777 firm-year observations. We use multiple regressions for the main analysis and Generalized Method of Moments (GMM) to test for endogeneity. The results show that board size is negatively significantly associated with the cost of debt, yet female board and independent boards are not related to cost of debt. The results are still consistent after testing for endogeneity issue.
Pengaruh layanan perbankan digital pada kepuasan nasabah perbankan
Authors: Susilawaty Lilis , Nicola Nicola
Published: May 2020

This study aims to determine whether digital banking services affect banking customer satisfaction. In accordance with previous research contained there are six measurements of digital banking services that affect banking customer satisfaction, namely comfort, functional quality, employee customer involvement, quality of digital banking services, brand/ trust, and digital banking innovation (Mbama & Ezepue, 2018). The data analysis technique used is quantitative verification analysis. The data used are primary data where the questionnaire was distributed to respondents using digital banking services of PT Bank Central Asia, Tbk. (Bank BCA). For the hypothesis, multiple regression analysis is tested. Before testing the data instrument testing and classical assumption tests are performed. In total 136 respondents, the results of this study indicate that comfort, functional quality, quality of digital banking services, brand/ trust, employee customer involvement, and digital banking innovation significantly influence customer satisfaction performance at Bank BCA. But partially, showing comfort, the quality of digital banking services, and brand/ trust does not affect the performance of banking customer satisfaction. Whereas functional quality, employee customer involvement, and digital banking innovation influence the performance of banking customer satisfaction.
Covid-19: Digital Signature Impact on Higher Education Motivation Performance
Authors: Rahardja Untung , Sudaryono Sudaryono , Santoso Nuke Puji Lestari , Faturahman Adam , Aini Qurotul
Published: May 2020

At present, the process of validating documents for certain purposes cannot be done face-to-face because of the Covid-19 pandemic. Therefore, this research aims to maximize the existence of smart digital signature technology that guarantees its safety and validity without having to meet face to face. Encrypted digital signatures with RSA-SHA256 with cloud storage features that can share documents. The waterfall method for building systems, the collection of data generated for analysis by observation, and online questionnaires using Google Form.  Based on the characteristics of the system, the satisfaction factor analysis of the system with the Slovin formula processed by the SUS score resulted in a score of 95 > 70. The final result of this study is that the digital signature system has a significant impact on increasing motivation to facilitate authorization and secure documents.
ADDITION OF SHELTERS TO CONTROL THE PHYSIOLOGICAL RESPONSES AND PRODUCTION OF MUD CRAB Scylla serrata IN RECIRCULATION AQUACULTURE SYSTEM
Authors: Hastuti Yuni Puji , Priyo Handoyo Wicaksono  , Wildan Nurusallam  , Siska Tridesianti  , Yuli Siti Fatma  , Kukuh Nirmala  , Iman Rusmana  , Ridwan Affandi
Published: May 2020

The availability of shelters in a specific density is expected to increase the production of mud crabs (Scylla serrata) in a recirculation system. Shelter, as one of the abiotic factors, plays a pivotal role in reducing death caused by cannibalism of crab and suppressing the stress levels of biota. Recirculation Aquaculture System (RAS), with the culture box capacity 60 L supported by the shelters, is predicted to produce the best physiological and growth responses of mud crabs. This present study aims to evaluate the effect of shelter addition in the environmental recirculation system on the physiological responses and production of mud crabs S. serrata with a density of 10 crabs per one culture box containing 60 L of seawater. The research was set up with three treatments of shelter addition, i.e., two shelters (S2), four shelters (S4), six shelters (S6), and control without shelter (C). Results showed that S6 was the best treatment with a survival rate of 73.33 ± 5.8%, a specific growth rate of 0.886 ± 0.014%, the growth rate of carapace width 0.024 ± 0.004 cm/day, and the lowest feed conversion ratio than those of other treatments. S6 treatment significantly influenced the total hemocyte count of crabs at the early cultivation (P <0.05). Addition of six shelters could optimize the growth of mud crabs with a stocking density of 10 crabs in one culture box.
PENGARUH TINGKAT PELAYANAN, CITRA KAMPUS, DAN KEPUASAN TERHADAP MOTIVASI MAHASISWA: STUDI KASUS MAHASISWA FAKULTAS EKONOMI UNIVERSITAS SRIWIJAYA
Authors: Eka Dian , Putri Yulia Hamdaini
Published: May 2020

Tujuan Penelitian: memahami pengaruh kualitas layanan, motivasi mahasiswa dan citra merek terhadap kepuasan mahasiswaDesain/Metodologi Penelitian : Teknik yang digunakan dalam penelitian ini yaitu pengujian hipotesis dengan menggunakan teknik model persamaan struktural.Temuan: Kualitas pelayanan tidak berpengaruh terhadap kepuasan mahasiswa, kualitas pelayanan tidak berpengaruh terhadap motivasi mahasiswa, Citra merk berpengaruh terhadap kepuasan mahasiswa, Citra merk berpengaruh terhadap motivasi mahasiswa, Kepuasan tidak berpengaruh terhadap motivasi mahasiswa, Citra merk memiliki pengaruh yang kuat secara langsung terhadap motivasi mahasiswa dibandingkan dengan pengaruh tidak langsung melalui variable kepuasan.Keterbatasan : penelitian ini berfokus pada penilaian kualitas pelayanan, citra merek, kepuasan dan motivasi dalam satu universitas.Originality/Value : artikel ini meneliti pengaruh tingkat pelayanan, citra  merek dan kepuasan terhadap motivasi. Keyword. tingkat pelayanan, citra  merek , kepuasan, motivasi.
COLAR DE PÉROLAS: A ESTRATÉGIA CHINESA PARA DOMINAR O MAR DO SUL DA CHINA (MSC) E A REGIÃO DO OCEANO ÍNDICO (ROI)
Authors: Friede Reis
Published: May 2020

As porções marítimas do Mar do Sul da China (MSC) e da Região do Oceano Índico (ROI) passaram a ostentar uma significativa importância no século XXI, em decorrência das inicialmente veladas, e agora ostensivas, ambições globais hegemônicas da China, que almeja conquistar um espaço de governança mundial em um novo cenário geopolítico global. Neste sentido, os anteriores ambientes conflituais, marcados por disputas territoriais, retornam à arena do “jogo de xadrez” próprio das relações internacionais, substituindo os clássicos embates ideológicos que tanto caracterizaram o contexto mundial a partir da segunda metade da centúria passada. Ainda que os novos conflitos em gestação estejam sendo travados sobre espaços marítimos situados nas regiões mencionadas (MSC e ROI), forçoso reconhecer que o ponto exato de confronto tenderá a se expandir para disputas em áreas adicionais, tais como a Antártida e a própria geórbita terrestre, fenômeno que inevitavelmente ensejará, na conjuntura geopolítica do presente século, uma Segunda Guerra Fria. Por ora, todavia, a controvérsia restringe-se e se dirige a temas que versam, estritamente, sobre os interesses econômicos e geopolíticos chineses nas localidades mencionadas, bem como na própria concepção estratégica do denominado “Colar de Pérolas”, tema que constitui a essência deste ensaio.
CULTURA E COMPORTAMENTO SOCIAL NA CIDADE GLOBAL
Authors: Martins Vanderlei
Published: May 2020

Esse ensaio trata de uma incursão de natureza sócio jurídica na convivência sócio institucional no espaço urbano contemporâneo globalizado. Discute de maneira pontual o espaço urbano como local de encontro de culturas diferenciadas entre si, mas que são conduzidas por uma mesma concepção de mundo derivada do tecnologismo contemporâneo que se manifesta impondo uma nova forma de convivência global e diversificada. Tal diversidade permite o convívio entre diferentes tendências que nem sempre são tolerantes entre si. Assim, o artigo discute a cidade contemporânea globalizada como ponto de encontro e desencontros culturais.