bluuebunny/crossref_metadata_2025 huggingface dataset:
What if She Earns More? Gender Norms, Income Inequality, and the Division of Housework
Authors: Magda Iga , Cukrowska-Torzewska Ewa , Palczyńska Marta
Published: May 2023

We examine the relationship between female contribution to household income and the division of housework between the partners, while accounting for their attitutes towards gender roles. We use data from the “Generation and Gender Survey” for Poland: a country where both employment rates of women and their involvement in housework are high, men and women work long hours, and labour market regulation and policies are unsupportive of work− family balance. We find that the female share of total household income is negatively related to women’s heavy involvement in housework. The direction of this relationship does not change when women earn more than their partners, so there is no support for the gender deviance neutralization hypothesis. We also find that individual gender norms matter for women’s involvement in unpaid work at home, and the uncovered link between the female share of household income and inequality between the partners in the division of housework. Women from less traditional households are more likely to share housework equally with their partners. Among couples with traditional gender attitudes, the female contribution to household income is not related to the division of housework. We conclude that narrowing gender pay gaps may be an important step towards more equality not only at work but also at home.
Well Posedness and Characterization of Solutions to Non Conservative Products in Non Homogeneous Fluid Dynamics Equations
Authors: Colombo Rinaldo M. , Guerra Graziano , Holle Yannick
Published: May 2023

Consider a balance law where the flux depends explicitly on the space variable. At jump discontinuities, modeling considerations may impose the defect in the conservation of some quantities, thus leading to non conservative products. Below, we deduce the evolution in the smooth case from the jump conditions at discontinuities. Moreover, the resulting framework enjoys well posedness and solutions are uniquely characterized. These results apply, for instance, to the flow of water in a canal with varying width and depth, as well as to the inviscid Euler equations in pipes with varying geometry.
Knockout of TRDMT1 methyltransferase affects DNA methylome in glioblastoma cells
Authors: Zabek Tomasz , Szmatola Tomasz , Adamczyk-Grochala Jagoda , Lewinska Anna , Wnuk Maciej
Published: May 2023

Purpose

We have previously shown that TRDMT1 methyltransferase is a regulator of chemotherapy-associated responses in glioblastoma cells. Despite the fact that glioblastoma, a common and malignant brain tumor, is widely characterized in terms of genetic and epigenetic markers, there are no data on TRDMT1-related changes in 5-methylcytosine pools in the genome. In the present study, the effect of TRDMT1 gene knockout (KO) on DNA methylome was analyzed.

Methods

CRISPR-based approach was used to obtain TRDMT1 KO glioblastoma cells. Total 5-methylcytosine levels in DNA, DNMT1 pools and DNMT activity were studied using ELISA. Reduced representation bisulfite sequencing (RRBS) was considered to comprehensively evaluate DNA methylome in glioblastoma cells with TRDMT1 KO.

Results

TRDMT1 KO cells were characterized by decreased levels of total 5-methylcytosine in DNA and DNMT1, and DNMT activity. RRBS-based methylome analysis revealed statistically significant differences in methylation-relevant DMS-linked genes in control cells compared to TRDMT1 KO cells. TRDMT1 KO-associated changes in DNA methylome may affect the activity of several processes and pathways such as telomere maintenance, cell cycle and longevity regulating pathway, proteostasis, DNA and RNA biology.

Conclusions

TRDMT1 may be suggested as a novel modulator of gene expression by changes in DNA methylome that may affect cancer cell fates during chemotherapy. We postulate that the levels and mutation status of TRDMT1 should be considered as a prognostic marker and carefully monitored during glioblastoma progression.
Translation of circHGF RNA encodes an HGF protein variant promoting glioblastoma growth through stimulation of c-MET
Authors: Saunders Jacquelyn T. , Kumar Sunil , Benavides-Serrato Angelica , Holmes Brent , Benavides Kennedy E. , Bashir Muhammad T. , Nishimura Robert N. , Gera Joseph
Published: May 2023

Introduction

HGF/c-MET signaling is a significant driver of glioblastoma (GBM) growth and disease progression. Unfortunately, c-MET targeted therapies have been found to be largely ineffective suggesting additional redundant mechanisms of c-MET activation.

Methods

Utilizing RNA-sequencing (RNA-seq) and ribosome profiling analyses of circular RNAs, circ-HGF (hsa_circ_0080914) was identified as markedly upregulated in primary GBM and found to potentially encode an HGF protein variant (C-HGF) 119 amino acids in length. This candidate HGF variant was characterized and evaluated for its ability to mediate c-MET activation and regulate PDX GBM cell growth, motility and invasive potential in vitro and tumor burden in intracranial xenografts in mice.

Results

An internal ribosome entry site (IRES) was identified within the circ-HGF RNA which mediated translation of the cross-junctional ORF encoding C-HGF and was observed to be highly expressed in GBM relative to normal brain tissue. C-HGF was also found to be secreted from GBM cells and concentrated cell culture supernatants or recombinant C-HGF activated known signaling cascades downstream of c-MET. C-HGF was shown to interact directly with the c-MET receptor resulting in its autophosphorylation and activation in PDX GBM lines. Knockdown of C-HGF resulted in suppression of c-MET signaling and marked inhibition of cell growth, motility and invasiveness, whereas overexpression of C-HGF displayed the opposite effects. Additionally, modulation of C-HGF expression regulated tumor growth in intracranial xenografted PDX GBM models.

Conclusions

These results reveal an alternative mechanism of c-MET activation via a circular RNA encoded HGF protein variant which is relevant in GBM biology. Targeting C-HGF may offer a promising approach for GBM clinical management.
The Casualties of War: An Excess Mortality Estimate of Lives Lost in the 2020 Nagorno-Karabakh Conflict
Authors: Karlinsky Ariel , Torrisi Orsola
Published: May 2023

Who and how many died in the 2020 Karabakh War? With limited evidence provided by authorities, media outlets, and human rights organizations, still little is known about the death toll caused by the 44-day conflict in and around Nagorno-Karabakh. This paper provides a first assessment of the human cost of the war. Using age–sex vital registration data from Armenia, Azerbaijan, and the de facto Republic of Artsakh/Nagorno-Karabakh, we difference the 2020 observed mortality values from expected deaths based on trends in mortality between 2015 and 2019 to offer sensible estimates of excess mortality resulting from the conflict. We compare and contrast our findings with neighboring peaceful countries with similar mortality patterns and socio-cultural background and discuss them against the backdrop of the concurrent first wave of Covid-19. We estimate that the war led to almost 6,500 excess deaths among people aged 15–49. Nearly 2,800 excess losses occurred in Armenia, 3,400 in Azerbaijan, and 310 in de facto Artsakh. Deaths were highly concentrated among late adolescent and young adult males, suggesting that most excess mortality was directly related to combat. Beyond the human tragedy, for small countries like Armenia and Azerbaijan, such loss of young men represents a considerable long-term cost for future demographic, economic, and social development.
Standing on the shoulders of giants or science? Lessons from ordoliberalism
Authors: Feld Lars P. , Köhler Ekkehard A.
Published: May 2023

James Buchanan would have celebrated his 100th birthday in 2019. This serves as an inspiration to look at the future of public choice and the question of how much normativity public choice can bear. In our analysis we draw parallels between public choice and German ordoliberalism (and its source in the Freiburg School of Economics). We argue that the reception of ordoliberalism exemplifies easy-to-grasp pitfalls that should be taken seriously. We anchor the future agenda of public choice in a solid individualist perspective. Similar to ordoliberalism, public choice will have to clarify its relation to normative economics. The effects of rules and institutions and their working properties should be thoroughly analyzed empirically. The role of ideas is important for the normative foundation of both public choice/ constitutional economics and ordoliberalism, and is rooted in normative individualism. It provides a benchmark by which rules and institutions can be judged as favorable.
Development and Characterization of Multilayered Cu/HA/ZnS + PEEK Coating System by Hybrid Technology
Authors: Kuśmierczyk Filip , Cieniek Łukasz , Kopia Agnieszka , Zimowski Sławomir , Moskalewicz Tomasz
Published: May 2023

In this study, multilayered Cu/HA/ZnS + PEEK coatings were fabricated using hybrid technology on Zr–2.5Nb alloy substrates. The use of electrophoretic deposition (EPD) and heat treatment allowed the 1st base composite ZnS + PEEK layer and the 2nd hydroxyapatite (HA) top layer to be obtained. The EPD kinetics of both layers was studied. Heating at a temperature of 450 °C and slow cooling resulted in densification and sulfonation of PEEK. It also led to an increase in the adhesion of HA particles on the surface of the PEEK + ZnS layer and to the settlement of HA particles deep into the 1st layer. The effect of substrate preparation on the adhesion strength of coatings was investigated. The ZnS + PEEK layer exhibited high adhesion to the chemically treated zirconium alloy. Furthermore, the first layer was characterized by a high scratch resistance. The selective distribution of Cu on the top of the coating was obtained by shadow-masked pulsed laser deposition (PLD). The multilayered coatings exhibited high roughness and mild hydrophobicity. This study showed the possibility of obtaining a multilayered coating system with a controlled distribution of bioactive components (HA) and antimicrobial components (Cu) on its surface using a hybrid method that combined EPD, heat treatment, and PLD.
Polymer-based Electrochemical Sensor: Fast, Accurate, and Simple Insulin Diagnostics Tool
Authors: Šišoláková Ivana , Gorejová Radka , Chovancová Frederika , Shepa Jana , Ngwabebhoh Fahanwi Asabuwa , Fedorková Andrea Straková , Sáha Petr , Oriňaková Renáta
Published: May 2023

Study of the use of polymers with higher conductivity like polypyrrole, and polyaniline in the electrochemical insulin sensors can overcome the drawbacks arising from the ongoing use of non-conductive polymer membrane. Conductive polymer membranes maintain the positive properties of polymers, like improved stability, reproducibility, and even increase the current response of the prepared sensor toward insulin oxidation. Three different screen-printed electrodes modified with polyaniline, polypyrrole, or chitosan with electrochemically deposited nickel nanoparticles ensuring insulin oxidation were prepared. The electrode morphology was examined via SEM with EDX analysis. Also, the electroactive surface area and stability were determined by voltammetric methods. Based on the results, the SPCEs modified by polypyrrole and nickel nanoparticles were determined as the most appropriate for the insulin determination. The NiNPs-PPy-SPCE exhibited a linear range (500 nM–5 µM), a low-down limit of detection (38 nM), high sensitivity (3.98 µA/µM), and excellent result from insulin determination in real samples (human blood serum). The results confirmed the high potential of developed sensor for future research focused on detection of insulin via electrochemistry methods in clinical samples.

Graphical Abstract
Magnetic photocatalysts based on graphene oxide: synthesis, characterization, application in advanced oxidation processes and response surface analysis
Authors: Abbasi Sedigheh
Published: May 2023

The decomposition rate of methyl orange (MO) is studied in aqueous solution of magnetic photocatalysts based on graphene oxide (GO). ZnO photocatalytic nanoparticles are synthesized with controlled amounts on magnetized graphene oxide and two photocatalytic samples including GFZ1 and GFZ2 are prepared for use in advanced oxidation process. The characterization of the synthesized photocatalysts is done by XRD, FTIR and VSM. The crystal structure of magnetic Fe3O4 nanoparticles as well as photocatalytic ZnO nanoparticles on the graphene oxide network has been confirmed by XRD analysis in both synthesized samples. FTIR analysis of both GFZ1 and GFZ2 also shows the stretching vibration of Fe–O and Zn–O bonds in Fe3O4 and ZnO, respectively. The superparamagnetic properties of both samples can be confirmed using VSM analysis. It is also observed that with the increase of ZnO nanoparticles in GFZ2, the magnetic properties decrease compared to GFZ1. The effect of irradiation time time (between 5 and 40 min), weight fraction of the synthesized photocatalysts (0.1%wt, 0.2%wt, and 0.3%wt) and pH of the suspension (3, 7, and 11) on the changes in MO decomposition rate was investigated and the response surface method (RSM) was used to study the effect of the simultaneous change of two parameters of the mentioned factors on the MO removal efficiency. The results show that with the increase of irradiation time and also the weight fraction of both photocatalysts, the decomposition rate of MO also increases significantly. So that in all time intervals and weight fractions, the photocatalytic activity of GFZ2 is much higher than that of GFZ1. The effect of pH also shows that the maximum and minimum decomposition rates occur in acidic and neutral conditions, respectively.
Advances in Design and Development of Lumi-Solve: A Novel Drug-Eluting Photo-Angioplasty Device
Authors: Sangeetha Menon Amarnath , Subasic de Azevedo Igor , Choong Kylie , Bhatnagar Dhruv , Wang Chen , Sluka Pavel , Chisholm David R. , Pasic Paul , Thissen Helmut , Sama Gopal , Robinson Andrea , Rodda Andrew , Tria Aldous , Spiegel Loren , Dharma Anak , Kaipananickal Harikrishnan , Okabe Jun , El-Osta Assam , Mountford Simon , Thompson Philip , Dear Anthony E.
Published: May 2023

Purpose

The Lumi-Solve photo-angioplasty drug eluting balloon catheter (DEBc) may afford safety advantages over current DEBc. Lumi-Solve utilises the guidewire (GW) port and lumen to deliver fibre-optic UV365nm light to the angioplasty balloon which may be problematic. We explore and evaluate alternative Lumi-Solve design options to circumvent fibre-optic use of the GW port and lumen which may enhance efficacy and clinical utility.

Methods

Effects of guidewire shadowing (GWS) on visible and UV365nm light transmission were evaluated and modelled in-silico. To evaluate the effect of a dedicated intra-balloon fibre-optic port, modified angioplasty balloons and sections of translucent polyethylene terephthalate (PET) GW port tubing were utilised. Investigation of the effect of GWS on chemical and biological photo-activation of balloon surface drug was performed utilising LCMS analysis and inhibition of histone deacetylase activity (HDACi) was measured in human umbilical vein endothelial cells (HUVEC).

Results

Parallel fibre-optic and GW port configurations generated a GWS of approximately 18.0% of the evaluable balloon surface area and attenuated both visible and UV light intensity by 20.0–25.0% and reduced chemical photo-activation of balloon surface drug and HDACi by at least 40–45%. Alternative fibre-optic port configurations including a spiral design significantly mitigated GWS effects on UV light transmission.

Conclusions

To avoid use of the GW port and its associated complications a dedicated third port and lumen for the Lumi-Solve fibre-optic may be required. To maximize balloon surface chemical and biological photo-activation, non-parallel, intra-balloon, fibre-optic lumen trajectories, including a spiral design may be useful.
On the structure of connected components of the moduli spaces of compact Riemann surfaces
Authors: Gromadzki Grzegorz , Szmelter Jakub
Published: May 2023

Using the Broughton’s equisymmetric stratification of the moduli space of compact Riemann surfaces of genus $$g \ge 2$$

g
≥
2

, Bartolini, Costa and Izquierdo have shown that its singular locus $$S_{g}$$

S
g

is disconnected except for $$g = 3, 4, 7, 13, 17, 19, 59$$

g
=
3
,
4
,
7
,
13
,
17
,
19
,
59

. One of a lot of problems motivated by this result concerns the study of its connected components, both from the quantitative and qualitative points of view. In 2012, Bartolini and Izquierdo have shown that all strata corresponding to the actions of $$Z_{2}$$

Z
2

and $$Z_{3}$$

Z
3

are contained in a single connected component $$C^{2,3}_g$$

C
g

2
,
3

. The other components which were known to these authors were those composed by single strata and they asked whether there are components different from $$C^{2,3}_ g $$

C
g

2
,
3

being the union at least two equisymmetric strata. The aim of this paper is to give an affirmative answer to this question, by showing that there are connected components composed of precisely two strata in $$S_{g}$$

S
g

for $$g = rp(p -1)/2$$

g
=
r
p
(
p
-
1
)
/
2

where $$r \ge 6$$

r
≥
6

and $$p > 5r + 3$$

p
>
5
r
+
3

is a prime for which $$pr + 2$$

p
r
+
2

is also a prime.
Using EGARCH models to predict volatility in unconsolidated financial markets: the case of European carbon allowances
Authors: Villar-Rubio Elena , Huete-Morales María-Dolores , Galán-Valdivieso Federico
Published: May 2023

The growing interest and direct impact of carbon trading in the economy have drawn an increasing attention to the evolution of the price of CO2 allowances (European Union Allowances, EUAs) under the European Union Emissions Trading Scheme (EU ETS). As a novel financial market, the dynamic analysis of its volatility is essential for policymakers to assess market efficiency and for investors to carry out an adequate risk management on carbon emission rights. In this research, the main autoregressive conditional heteroskedasticity (ARCH) models were applied to evaluate and analyze the volatility of daily data of the European carbon future prices, focusing on the last finished phase of market operations (phase III, 2013–2020), which is structurally and significantly different from previous phases. Some empirical findings derive from the results obtained. First, the EGARCH (1,1) model exhibits a superior ability to describe the price volatility even using fewer parameters, partly because it allows to collect the sign of the changes produced over time. In this model, the Akaike information criterion (AIC) is lower than ARCH (4) and GARCH (1,1) models, and all its coefficients are significative (p < 0.02). Second, a sustained increase in prices is detected at the end of phase III, which makes it possible to foresee a stabilization path with higher prices for the first years of phase IV. These changes will motivate both companies and individual energy investors to be proactive in making decisions about the risk management on carbon allowances.
Solvent-free carbon sphere nanofluids towards intelligent lubrication regulation
Authors: Zhang Sheng , Li Wen , Ma Xiaoliang , Fan Xiaoqiang , Zhu Minhao
Published: May 2023

By simply switching the electrical circuit installed on steel/steel contact, the tribological behaviors of nanofluids (NFs) can be regulated in real time, thereby achieving the desired performance of friction reduction and wear resistance. Herein, solvent-free carbon spherical nanofluids (C-NFs) were successfully prepared for intelligent lubrication regulation. C-NFs with excellent lubrication performance can immediately reduce the coefficient of friction (COF) despite applying a weak electric potential (1.5 V). Moreover, polyethylene glycol 400 (PEG400) containing 5.0 wt% C-NFs remained responsive to electrical stimulation under the intermittent voltage application with an average coefficient of friction (ACOF) reduction of 20.8% over PEG400. Such intelligent lubrication regulation of C-NFs under an external electric field (EEF) mainly depends on the orderly arranged double-electric adsorption film of ion canopy-adsorbed carbon spheres (CSs). The intermittent electrical application can continuously reinforce the adsorption film and its durability for real-time controlling the sliding interfaces. Electrical-stimulation-responsive intelligent lubricants provide a new technical support for realizing intelligent stepless control of devices.
L’eterogeneità del meccanismo autoimmune che conduce al diabete tipo 1 giustifica il fallimento dell’immunoterapia?
Authors: Pieralice Silvia , D’Onofrio Luca , Buzzetti Raffaella
Published: May 2023

Sommario

Nonostante l’impegno profuso dai ricercatori negli ultimi 30 anni, ad oggi nessuno studio di immuno-intervento è riuscito a indurre la remissione del diabete tipo 1 (DM1) dopo l’insorgenza clinica. Una possibile causa risiede nell’ampia eterogeneità della patologia, che non riguarda solo aspetti metabolici e clinici, ma anche patogenetici e immunologici. Questa osservazione trova conferma nella recente introduzione del concetto di “endotipo”, ovvero nell’esistenza di specifici sottotipi di diabete autoimmune, definiti da meccanismi funzionali e fisiopatologici distinti. Questo nuovo concetto implica che percorsi fisiopatologici diversi possano esitare nella stessa malattia, ma anche che studi di immuno-intervento che mirano a intercettare uno di quei percorsi, possano avere un successo limitato perché applicati indistintamente a tutta la popolazione con DM1. L’implementazione di immuno-terapia in endotipi specifici potrebbe essere di maggiore efficacia nell’ottica di una medicina di precisione.
Cervantes the Poet
Authors: Ponce-Hegenauer Gabrielle
Published: May 2023

Cervantes the Poet travels from the court of Isabel de Valois to Rome, Naples, Palermo, Algiers, and Madrid's barrio de las letras. Recovering Cervantes' nearly forty-year literary career before the publication of Don Quijote, Gabrielle Ponce-Hegenauer demonstrates the cultural, literary, and theoretical significance of Cervantes' status as a late-sixteenth-century itinerant poet. This study recovers the generative literary milieus and cultural practices of Spain's most famous novelist in order to posit a new theory of the modern novel as an organic transformation of lyric practices native to the late-sixteenth century and Cervantes' own literary outlook.
Kant's Critique of Pure Reason and the Method of Metaphysics
Authors: Gava Gabriele
Published: May 2023

In two often neglected passages of the Critique of Pure Reason, Kant submits that the Critique is a 'treatise' or a 'doctrine of method'. These passages are puzzling because the Critique is only cursorily concerned with identifying adequate procedures of argument for philosophy. In this book, Gabriele Gava argues that these passages point out that the Critique is the doctrine of method of metaphysics. Doctrines of method have the task of showing that a given science is indeed a science because it possesses 'architectonic unity' – which happens when it realizes the 'idea' of a science. According to Gava's novel approach, the Critique establishes that metaphysics is capable of this unity, and his reading of the Critique from this perspective not only illuminates the central role of the Transcendental Doctrine of Method within it, but also clarifies the relationship between the different parts of the work.
Life without God
Authors: Peels Rik
Published: May 2023

In this book, Rik Peels explores atheism from a new perspective that aims to go beyond the highly polarized debate about arguments for and against God's existence. Since our beliefs about the most important things in life are not usually based on arguments, we should look beyond atheistic arguments and explore what truly motivates the atheist. Are there certain ideals or experiences that explain the turn to atheism? Could atheism be the default position for us, not requiring any arguments whatsoever? And what about the often-discussed arguments against belief in God—is there something that religious and nonreligious people alike can learn from them? This book explores how a novel understanding of atheism is possible – and how it effectively moves the God debate further. Believers and non-believers can learn much from Peel's assessment of arguments for and against atheism.
Ethics in the Gray Area
Authors: Peterson Martin
Published: May 2023

What should morally conscientious agents do if they must choose among options that are somewhat right and somewhat wrong? Should one select an option that is right to the highest degree, or would it perhaps be more rational to choose randomly among all somewhat right options? And how should lawmakers and courts address behaviour that is neither entirely right nor entirely wrong? In this first book-length discussion of the 'gray area' in ethics, Martin Peterson challenges the assumption that rightness and wrongness are binary properties and explores acts which are neither entirely right nor entirely wrong, but rather a bit of both. Including discussions of white lies and the permissibility of abortion, Peterson's book presents a gradualist theory of right and wrong designed to answer these and other practical questions about the gray area in ethics.
Introduction to Choreographies
Authors: Montesi Fabrizio
Published: May 2023

In concurrent and distributed systems, processes can complete tasks together by playing their parts in a joint plan. The plan, or protocol, can be written as a choreography: a formal description of overall behaviour that processes should collaborate to implement, like authenticating a user or purchasing an item online. Formality brings clarity, but not only that. Choreographies can contribute to important safety and liveness properties. This book is an ideal introduction to theory of choreographies for students, researchers, and professionals in computer science and applied mathematics. It covers languages for writing choreographies and their semantics, and principles for implementing choreographies correctly. The text treats the study of choreographies as a discipline in its own right, following a systematic approach that starts from simple foundations and proceeds to more advanced features in incremental steps. Each chapter includes examples and exercises aimed at helping with understanding the theory and its relation to practice.
COMPUTABLY COMPACT METRIC SPACES
Authors: DOWNEY RODNEY G. , MELNIKOV ALEXANDER G.
Published: May 2023

We give a systematic technical exposition of the foundations of the theory of computably compact metric spaces. We discover several new characterizations of computable compactness and apply these characterizations to prove new results in computable analysis and effective topology. We also apply the technique of computable compactness to give new and less combinatorially involved proofs of known results from the literature. Some of these results do not have computable compactness or compact spaces in their statements, and thus these applications are not necessarily direct or expected.
On Markov chain approximations for computing boundary crossing probabilities of diffusion processes
Authors: Liang Vincent , Borovkov Konstantin
Published: May 2023

We propose a discrete-time discrete-space Markov chain approximation with a Brownian bridge correction for computing curvilinear boundary crossing probabilities of a general diffusion process on a finite time interval. For broad classes of curvilinear boundaries and diffusion processes, we prove the convergence of the constructed approximations in the form of products of the respective substochastic matrices to the boundary crossing probabilities for the process as the time grid used to construct the Markov chains is getting finer. Numerical results indicate that the convergence rate for the proposed approximation with the Brownian bridge correction is
$O(n^{-2})$
in the case of
$C^2$
boundaries and a uniform time grid with n steps.
Missing in action? Mortgage enforcement under section 126 of the Consumer Credit Act 1974
Authors: Whitehouse Lisa , Crampin Cecily
Published: May 2023

This paper sets out the true ambit of section 126 of the Consumer Credit Act 1974, noting that it requires virtually all residential mortgage agreements to be enforced by court order. Despite this, numerous commentaries on the English law of mortgage omit reference to section 126. The implications of our findings are profound. Not least, many accounts of the law of mortgage will require substantial revision, including recognition of the fact that cases such as Ropaigealach v Barclays Bank plc and Horsham Properties Group Ltd v Clark were reversed as long ago as 2008. More significant is the need to ensure that accurate knowledge of section 126 is conveyed to those who advise mortgagors at risk of possession. This is particularly the case given the ‘cost of living crisis’ and the backlog of possession claims arising out of the Covid-19 pandemic. Any mortgagees tempted to expedite recovery of mortgaged property by enforcing the mortgage extra-judicially should be directed to section 126 and the requirement it imposes to obtain a court order.
ROMAN BOOKS AND THE PAPAL LIBRARY IN THE EARLY MIDDLE AGES
Authors: McKitterick Rosamond
Published: May 2023

This paper offers a fresh appraisal of the problems of the existence, location and contents of the papal library, and the associated problems of Roman script and Roman book production in the early Middle Ages. The palaeography and codicology of books from Rome, and books possibly produced in Rome, between the sixth and the ninth centuries, are reassessed in the light of current scholarship. This includes a discussion of the possible loss of Roman books originally written on papyrus, and of books in both Latin and Greek. The current archaeological evidence relating to a Lateran library and its location is considered. The implications of the evidence relating to the papalscrinium, archive and library are discussed, with particular reference to the proceedings of the Lateran Council of 649. It is argued that these records actually provide important evidence for the contents and use of the Lateran library in the early Middle Ages. The paper proposes that the papal library had a crucial function as well as a symbolic role in the early Middle Ages as a repository of orthodox and authoritative texts.
Compatible finite element methods for geophysical fluid dynamics
Authors: Cotter Colin J.
Published: May 2023

This article surveys research on the application of compatible finite element methods to large-scale atmosphere and ocean simulation. Compatible finite element methods extend Arakawa’s C-grid finite difference scheme to the finite element world. They are constructed from a discrete de Rham complex, which is a sequence of finite element spaces linked by the operators of differential calculus. The use of discrete de Rham complexes to solve partial differential equations is well established, but in this article we focus on the specifics of dynamical cores for simulating weather, oceans and climate. The most important consequence of the discrete de Rham complex is the Hodge–Helmholtz decomposition, which has been used to exclude the possibility of several types of spurious oscillations from linear equations of geophysical flow. This means that compatible finite element spaces provide a useful framework for building dynamical cores. In this article we introduce the main concepts of compatible finite element spaces, and discuss their wave propagation properties. We survey some methods for discretizing the transport terms that arise in dynamical core equation systems, and provide some example discretizations, briefly discussing their iterative solution. Then we focus on the recent use of compatible finite element spaces in designing structure preserving methods, surveying variational discretizations, Poisson bracket discretizations and consistent vorticity transport.
Projecting Global Drought Risk Under Various SSP‐RCP Scenarios
Authors: Zhou Zhiling , Zhang Liping , Chen Jie , She Dunxian , Wang Gangsheng , Zhang Qin , Xia Jun , Zhang Yanjun
Published: May 2023

Drought risk assessment can identify high‐risk areas and bridge the gap between impacts and adaptation. It is thus vital to investigate changes in drought risk and exposed social economy under climate change. Here, the future global meteorological drought risk is projected for the 2021–2100 period under four combined scenarios of Representative Concentration Pathways and Shared Socioeconomic Pathways (SSPs), i.e., SSP1‐2.6, SSP2‐4.5, SSP3‐7.0, and SSP5‐8.5. And then the exposed population and Gross Domestic Product (GDP) under high risk are analyzed. Drought risk will further strengthen in the future under SSP2‐4.5, SSP3‐7.0, and SSP5‐8.5, with large increases distributed in South Asia, the Mediterranean, East Asia, Southeast Asia, and Central America. The strongest increasing trends in drought risk are concentrated in equatorial regions including South Asia, West Africa, and Central America. A large percentage of the population and economy are exposed to high drought risk. The exposed population under the highest risk level is the largest under SSP5‐8.5 and the smallest under SSP3‐7.0 for regions in North America, while being the largest under SSP3‐7.0 for other regions. The exposed GDP under the highest risk level is the highest under SSP5‐8.5 and the lowest under SSP3‐7.0, while the disparity among diverse scenarios is larger for the rich regions than the developing ones.
Acceleration of the Onset Speeds of Heat Waves Over East China by Upwind Flash Droughts
Authors: Zhou Shiyu , Yuan Xing
Published: May 2023

The summer temperatures in 2022 have exceeded historical records over the Northern Hemisphere, leading to compound extreme events of droughts and heat waves (HWs) with rapid intensification. This type of compound extreme event has raised unprecedented social concerns. Previous studies have found that upwind droughts can enhance the intensity of HWs through advected sensible heat, but how the droughts affect the onset speed of HWs remains unclear, which is key to HW early warning. By using a Lagrangian model to track the air mass trajectory during the HWs, here we show that upwind droughts enhance 21% of the HWs over East China, and the upwind droughts with faster onset speeds (i.e., flash droughts) have a greater impact on HWs than the slowly evolving droughts. The strong negative soil moisture anomaly caused by a persistent anticyclone increases sensible heating, leading to the increases of total sensible heat and atmospheric boundary layer height over East China. Meanwhile, the rapid onset of flash drought is accompanied by the intensified anticyclone and rapid accumulation of advected sensible heat, and these increase the HW onset speed. Compared with the antecedent upwind slow droughts, the antecedent upwind flash droughts and the associated anticyclone accelerate the HW onset speed by 43% significantly. Our research shows that flash drought is a critical precursor for an extreme HW in the downwind region.
Toward Cloud‐Native, Machine Learning Base Detection of Crop Disease With Imaging Spectroscopy
Authors: Rubambiza Gloire , Romero Galvan Fernando , Pavlick Ryan , Weatherspoon Hakim , Gold Kaitlin M.
Published: May 2023

Developing actionable early detection and warning systems for agricultural stakeholders is crucial to reduce the annual $200B USD losses and environmental impacts associated with crop diseases. Agricultural stakeholders primarily rely on labor‐intensive, expensive scouting and molecular testing to detect disease. Spectroscopic imagery (SI) can improve plant disease management by offering decision‐makers accurate risk maps derived from Machine Learning (ML) models. However, training and deploying ML requires significant computation and storage capabilities. This challenge will become even greater as global‐scale data from the forthcoming Surface Biology & Geology satellite becomes available. This work presents a cloud‐hosted architecture to streamline plant disease detection with SI from NASA’s AVIRIS‐NG platform, using grapevine leafroll‐associated virus complex 3 (GLRaV‐3) as a model system. Here, we showcase a pipeline for processing SI to produce plant disease detection models and demonstrate that the underlying principles of a cloud‐based disease detection system easily accommodate model improvements and shifting data modalities. Our goal is to make the insights derived from SI available to agricultural stakeholders via a platform designed with their needs and values in mind. The key outcome of this work is an innovative, responsive system foundation that can empower agricultural stakeholders to make data‐driven plant disease management decisions while serving as a framework for others pursuing use‐inspired application development for agriculture to follow that ensures social impact and reproducibility while preserving stakeholder privacy.
In Praise of the Unexpected
Authors: Lanchester Betty
Published: May 2023

There are many advantages to having an open mind in science; not being too set on a particular direction or outcome can be a good thing. For me, a career in Space Physics was completely serendipitous and certainly unexpected. Over the years I have been mentor and advisor to many students who have set their hearts on a career in Space Physics, and it has been a pleasure to be able to encourage and help them follow that ambition, while admiring their sense of purpose and forward planning. But my own experience was quite different—things just happened. So my advice is to welcome unexpected turns, and at the scientific level, to be ready to embrace a result that surprises, or maybe even disappoints. To quote from Mike Lockwood’s Frontiers article “In Praise of Mistakes” (Lockwood, 2022, https://doi.org/10.3389/fspas.2022.852798) which inspired this article’s title, “If one can recognize a mistake, it is often a path to unexpected progress.”
Dynamic Two‐Phase Flow Modeling of Melt Segregation in Continental Crust: Batholith Emplacement Versus Crustal Convection, With Implications for Magmatism in Thickened Plateaus
Authors: Schmeling Harro , Marquart Gabriele , Weinberg Roberto , Kumaravel Pirunthavan
Published: May 2023

Magmatic processes in the continental crust such as crustal convection, melt ascent, magma emplacement, and batholith formation are not well understood. We solve the conservation equations for mass, momentum, and energy for two‐phase flow of melt and solid in 2D, for a thick continental crust heated from below by one or several heat pulses. A simplified binary melting model is incorporated. We systematically vary (a) the retention number, characterizing melt mobility, (b) the intensity of heat pulses applied at the bottom, and (c) the density of the solidified evolved rock. Two characteristic modes are identified: (a) in the “batholith emplacement mode,” segregation is sufficiently strong allowing melts to separate from the convective flow. This melt freezes to form buoyant SiO2‐rich layers. (b) In the “convective recycling mode,” melts are formed in the lower crust, rise together with the hot rock with little segregation, freeze at shallow depth but are partly recycled back to the lower crust where they remelt. Phase‐change‐driven convection dominates. Mode (a) is favored by high heat input, multiple heat pulses, high melt mobility, and low density of the evolved rock. Mode (b) is favored by less intense heating, less melt mobility, and denser evolved rocks. A scaling law is derived based on the thermal, melt, and compositional Rayleigh numbers and the retention number. The Altiplano‐Puna low‐velocity zone (LVZ) could represent the batholith emplacement mode with buoyant and voluminous magmas causing intense volcanism. The Tibetan LVZ is not associated with intense volcanism and might represent the convective recycling mode.
Metal3D: a general deep learning framework for accurate metal ion location prediction in proteins
Authors: Dürr Simon L. , Levy Andrea , Rothlisberger Ursula
Published: May 2023

Metal ions are essential cofactors for many proteins and play a crucial role in many applications such as enzyme design or design of protein-protein interactions because they are biologically abundant, tether to the protein using strong interactions, and have favorable catalytic properties. Computational design of metalloproteins is however hampered by the complex electronic structure of many biologically relevant metals such as zinc . In this work, we develop two tools - Metal3D (based on 3D convolutional neural networks) and Metal1D (solely based on geometric criteria) to improve the location prediction of zinc ions in protein structures. Comparison with other currently available tools shows that Metal3D is the most accurate zinc ion location predictor to date with predictions within 0.70 ± 0.64 Å of experimental locations. Metal3D outputs a confidence metric for each predicted site and works on proteins with few homologes in the protein data bank. Metal3D predicts a global zinc density that can be used for annotation of computationally predicted structures and a per residue zinc density that can be used in protein design workflows. Currently trained on zinc, the framework of Metal3D is readily extensible to other metals by modifying the training data.
Comparing ecosystem gaseous elemental mercury fluxes over a deciduous and coniferous forest
Authors: Zhou Jun , Bollen Silas W. , Roy Eric M. , Hollinger David Y. , Wang Ting , Lee John T. , Obrist Daniel
Published: May 2023

Sources of neurotoxic mercury in forests are dominated by atmospheric gaseous elemental mercury (GEM) deposition, but a dearth of direct GEM exchange measurements causes major uncertainties about processes that determine GEM sinks. Here we present three years of forest-level GEM deposition measurements in a coniferous forest and a deciduous forest in northeastern USA, along with flux partitioning into canopy and forest floor contributions. Annual GEM deposition is 13.4 ± 0.80 μg m−2 (coniferous forest) and 25.1 ± 2.4 μg m−2 (deciduous forest) dominating mercury inputs (62 and 76% of total deposition). GEM uptake dominates in daytime during active vegetation periods and correlates with CO2 assimilation, attributable to plant stomatal uptake of mercury. Non-stomatal GEM deposition occurs in the coniferous canopy during nights and to the forest floor in the deciduous forest and accounts for 24 and 39% of GEM deposition, respectively. Our study shows that GEM deposition includes various pathways and is highly ecosystem-specific, which complicates global constraints of terrestrial GEM sinks.
Detecting recurrent passenger mutations in melanoma by targeted UV damage sequencing
Authors: Selvam Kathiresan , Sivapragasam Smitha , Poon Gregory M. K. , Wyrick John J.
Published: May 2023

Sequencing of melanomas has identified hundreds of recurrent mutations in both coding and non-coding DNA. These include a number of well-characterized oncogenic driver mutations, such as coding mutations in the BRAF and NRAS oncogenes, and non-coding mutations in the promoter of telomerase reverse transcriptase (TERT). However, the molecular etiology and significance of most of these mutations is unknown. Here, we use a new method known as CPD-capture-seq to map UV-induced cyclobutane pyrimidine dimers (CPDs) with high sequencing depth and single nucleotide resolution at sites of recurrent mutations in melanoma. Our data reveal that many previously identified drivers and other recurrent mutations in melanoma occur at CPD hotspots in UV-irradiated melanocytes, often associated with an overlapping binding site of an E26 transformation-specific (ETS) transcription factor. In contrast, recurrent mutations in the promoters of a number of known or suspected cancer genes are not associated with elevated CPD levels. Our data indicate that a subset of recurrent protein-coding mutations are also likely caused by ETS-induced CPD hotspots. This analysis indicates that ETS proteins profoundly shape the mutation landscape of melanoma and reveals a method for distinguishing potential driver mutations from passenger mutations whose recurrence is due to elevated UV damage.
Base-resolution UV footprinting by sequencing reveals distinctive damage signatures for DNA-binding proteins
Authors: Elliott Kerryn , Singh Vinod Kumar , Boström Martin , Larsson Erik
Published: May 2023

Decades ago, it was shown that proteins binding to DNA can quantitatively alter the formation of DNA damage by UV light. This established the principle of UV footprinting for non-intrusive study of protein-DNA contacts in living cells, albeit at limited scale and precision. Here, we perform deep base-resolution quantification of the principal UV damage lesion, the cyclobutane pyrimidine dimer (CPD), at select human promoter regions using targeted CPD sequencing. Several transcription factors exhibited distinctive and repeatable damage signatures indicative of site occupancy, involving strong (up to 17-fold) position-specific elevations and reductions in CPD formation frequency relative to naked DNA. Positive damage modulation at some ETS transcription factor binding sites coincided at base level with melanoma somatic mutation hotspots. Our work provides proof of concept for the study of protein-DNA interactions at individual loci using light and sequencing, and reveals widespread and potent modulation of UV damage in regulatory regions.
Quench dynamics of Fano-like resonances in the presence of the on-dot superconducting pairing
Authors: Barański Jan , Barańska Magdalena , Zienkiewicz Tomasz , Kapcia Konrad Jerzy
Published: May 2023

We explore the electron dynamics of a system composed of double quantum dot embedded between metallic and superconducting leads in a “T-shape” geometry. In nanoscopic systems, where electron transfer between electrodes can be realized via different paths, interference effects play an important role. For double quantum dot system in the chosen geometry, interference of electrons transferred between electrodes via the interfacial quantum dot and electrons scattered on the side dot gives rise to Fano-like interference. If such a system is additionally coupled to a superconducting electrode, together with the well-understood Fano resonance an additional resonance appears on the opposite side of the Fermi level. In the recent work (Barański et al. in Sci Rep 10:2881, 2020), we showed that this resonance occurs solely as a result of the local pairing of non-scattered electrons with scattered ones. In this work, considering the quench dynamics, we explore how much time is required for formation of each of these resonances. In particular, (i) we analyze the charge oscillations between subsystems; (ii) we estimate the time required for each resonance to achieve stable equilibrium upon an abrupt change of interdot connection; (iii) we discuss a typical energy and time scales for experiments on similar architectures.
Fe3O4@SiO2@KIT-6@2-ATP@CuI as a catalyst for hydration of benzonitriles and reduction of nitroarenes
Authors: Moradi Zahra , Ghorbani-Choghamarani Arash
Published: May 2023

In this paper, a new type of magnetic mesoporous material (Fe3O4@SiO2@KIT-6@2-ATP@CuI) was designed and synthesized and its application in the synthesis of amides and anilines was investigated. The structure of Fe3O4@SiO2@KIT-6@2-ATP@CuI was characterized and identified using FTIR, SEM, XRD, TGA, BET, VSM, and ICP techniques. An external magnet can easily remove the synthesized catalyst from the reaction medium, and be reused in several consequence runs.