bluuebunny/crossref_metadata_2025 huggingface dataset:
High-efficiency tandem Ho:YAG single-crystal fiber laser delivering more than 100 W output power
Authors: Wang Jianlei , Tong Zihao , Zheng Changsheng , Du Tianyi , Zhao Yongguang , Wang Chun
Published: May 2024

We report on a high-efficiency, high-power tandem Ho:YAG single-crystal fiber (SCF) laser in-band pumped by a Tm-doped fiber laser at 1907 nm. In addition to the uniform heat distribution resulting from the large surface-to-volume ratio of this fiber-like thin-crystal rod, the long gain region provided by the tandem layout of two SCFs enables high lasing efficiency and power handling capability. More than 100 W output power is achieved at 2.1 μm, corresponding to a slope efficiency of 70.5% and an optical-to-optical efficiency of 67.6%. To the best of our knowledge, this is the highest output power and efficiency ever reported from SCF lasers in the 2-μm spectral range.
Freeze-out of perturbation growth for shocked heavy fluid layers by eliminating reverberating waves
Authors: Cong Zhouyang , Guo Xu , Zhou Zhangbo , Cheng Wan , Si Ting
Published: May 2024

The shock wave accelerating a heavy fluid layer can induce reverberating waves that continuously interact with the first and second interfaces. In order to manipulate the perturbation growths at fluid-layer interfaces, we present a theoretical framework to eliminate the reverberating waves. A model is established to predict the individual freeze-out (i.e. stagnation of perturbation growth) for the first and second interfaces under specific flow conditions determined based on the shock dynamics theory. The theoretical model quantifies the controllable parameters required for freeze-out, including the initial amplitudes of the first and second interfaces, the interface coupling strength and the maximum initial layer thickness preventing the second interface's phase reversal. The effectiveness of the model in predicting individual freeze-out for the first and second interfaces is validated numerically over a wide range of initial conditions. The upper and lower limits of initial amplitudes for the freeze-out of the whole fluid-layer width growth are further predicted. Within this amplitude range, a slightly higher initial amplitude for the second interface is specified, effectively arresting the growth of the entire fluid-layer width before the phase reversal of the second interface.
Perturbation analysis for continuous-time Markov chains in a weak sense
Authors: Lin Na , Liu Yuanyuan
Published: May 2024

By the technique of augmented truncations, we obtain the perturbation bounds on the distance of the finite-time state distributions of two continuous-time Markov chains (CTMCs) in a type of weaker norm than the V-norm. We derive the estimates for strongly and exponentially ergodic CTMCs. In particular, we apply these results to get the bounds for CTMCs satisfying Doeblin or stochastically monotone conditions. Some examples are presented to illustrate the limitation of the V-norm in perturbation analysis and to show the quality of the weak norm.
Policing neighborhood boundaries and the racialized social control of spaces
Authors: Neil Roland , Legewie Joscha
Published: May 2024

Prior scholarship has established that controlling space is central to policing, while highlighting various ways in which this form of social control can be racialized. Extending this work, we advance a theory on the racialized control of space that predicts a higher level of police stops and lower standards of suspicion along neighborhood racial boundaries, the areas where racial composition changes between adjacent neighborhoods. Our theoretical argument sheds light on the selective enforcement of law and order in these transitional spaces, which is a form of racialized spatial social control. Integrating data from New York City’s Stop, Question, and Frisk program from 2008 to 2012 with extensive neighborhood measures, our analyses reveal that White neighborhoods along boundaries experienced substantially elevated levels of police stops even after conditioning on a wide array of potential confounders. This relationship is partially mediated by elevated crime along neighborhood racial boundaries. Still, a sizable direct effect persists, indicative of the racialized social control of spaces. Further, the police tended to require less suspicion before deciding to conduct stops in White neighborhoods along racial boundaries, but only for Black and Hispanic suspects. Implications for the study of race and policing, law and society, and urban and racial inequality are discussed.
Framing and prosecutorial discretion: evidence from Brazil
Authors: Vilaça Luiz
Published: May 2024

Prior studies in the United States argue that the discretionary decisions of federal prosecutors regarding which issues to prioritize are shaped by the politicians who appoint them, while studies on state prosecutors emphasize the role of press coverage and public opinion. However, these studies leave untheorized whether prosecutors’ discretionary decisions are also affected by how their peers frame issues within and beyond prosecution offices. Building on the scholarship of collective action frames, this study develops a framework to explain how prosecutors’ framing work affects their colleagues’ decisions about which issues to focus on. I draw on the case of Brazil, where federal prosecutors focused on crime-fighting and human rights, but in the mid-2010s switched focus to corruption following a large-scale investigation called Lava Jato. I compare Lava Jato with two similarly large investigations that failed to transform corruption into the dominant issue within the Public Prosecutor’s Office. Drawing on 131 original interviews, I show how federal prosecutors’ framing work can persuade their colleagues to focus on the same issue through two stages: (1) conceptualization of versatile frames that speak to problems a variety of issues prosecutors care about and (2) diffusion of frames through professional meetings – providing roadmaps for how other prosecutors can implement the new frame – and to the press, increasing public attention.
Contemporary Financial Nationalism in Theory and Practice
Authors: Johnson Juliet , Barnes Andrew
Published: May 2024

The 2008 global financial crisis and its aftermath provided fertile soil for criticism of and alternatives to the international liberal order, including the rise of financial nationalism. Contemporary financial nationalism is a view of the world that is nationalist in its motivation for political action, financial in its policy focus, and illiberal in its conception of political economy. At the same time, it is fundamentally shaped by its emergence from within the international liberal order, which both constrains the policy options of financial nationalists and provides opportunities for them to draw on transnational financial resources and institutions to advance nationalist causes. This article offers a conceptual analysis of contemporary financial nationalism that explores its fundamental characteristics, explains what is distinctive about it, delineates its four major policy subtypes, identifies the resources and capabilities required to successfully engage in it, and discusses the implications of doing so. It aids researchers in thinking about financial nationalism’s internal workings across different contexts, in understanding why it has lasted as long and spread as far as it has, in considering how it may evolve, and in contemplating how it can affect domestic and international political economies.
Will the Global Plastics Treaty break the plastic wave? The beginning of a long discussion road
Authors: de Sousa Fabiula Danielli Bastos
Published: May 2024

We are experiencing the effects of the triple planetary crisis—climate change, loss of nature, and pollution—aggravated by plastic pollution. Despite widespread global awareness of the adverse effects of plastic pollution, its ongoing increase remains persistent, with an annual increase in plastic consumption and incorrect disposal contributing to this serious problem. In 2022, 175 nations agreed to begin negotiations by the end of 2024 on a binding international agreement to control the life cycle of plastics, including preventing marine pollution. To ensure the efficacy of the Global Plastics Treaty for mitigating plastic pollution, the extensive participation of researchers is imperative. The literature focuses on efforts in line with ongoing negotiations. In this study, a systematic review of the Global Plastics Treaty was conducted. The analyzed literature mainly focuses on the adverse effects of plastic pollution, legislation, governance, and the economy. The resulting comprehensive overview of the subject can support ongoing negotiations and guide future research about the Global Plastics Treaty.
The Mitonuclear Compatibility Species Concept, Intrinsic Essentialism, and Natural Kinds
Authors: Heine Kyle B. , Shech Elay
Published: May 2024

This essay introduces, develops, and appraises the mitonuclear compatibility species concept (MCSC), identifying advantages and limitations with respect to alternative species concepts. While the consensus amongst most philosophers of biology is that (kind) essentialism about species is mistaken, and that species at most have relational essences, we appeal to the MCSC to defend thoroughgoing intrinsic essentialism. Namely, the doctrine that species have fully intrinsic essences and, thus, are natural kinds (of sorts), while allowing that species aren’t categorically distinct.
CRIMINAL INTENT IN NINETEENTH-CENTURY ENGLAND
Authors: Handler Philip
Published: May 2024

This article examines how intention became key to criminal responsibility in nineteenth-century England. It focuses on trials where judges wrested with defence counsel and juries for control over its determination. The most important rule that developed to support proof of intention was the presumption that a person intended the natural and probable consequences of their actions. The article charts the origins and functions of the presumption to offer a revised view of the nineteenth-century foundations of the modern law of criminal intention.
Categorical Inequalities and Canadian Attitudes toward Positive and Negative Rights
Authors: Bloemraad Irene , Harell Allison , Fraser Nicholas A.R.
Published: May 2024

Liberal democracies are expected to provide residents with both negative rights, such as limitations against the abuse of police powers, and some range of positive (social) rights, such as access to social benefits. These rights are commonly deemed to apply equally, without respect to individuals’ ascriptive backgrounds. Existing research, often in the US context and focused on social programs, shows both support for abstract rights and group-specific prejudices. We interrogate whether similar patterns exist in Canada and innovate by directly examining negative and positive rights in the same study. Using a series of novel survey experiments, we demonstrate the degree to which categorical inequalities based on race and legal status affect public support for rights provision in Canada. Both rights are more recognized for citizens relative to out-of-status migrants, and legal status at times interacts with racialized minority status. Rights appear far from universal in the minds of Canadians.
An in vivo appraisal of Punica granatum peel extract’s ultrastructural effect on cystic echinococcosis in mice
Authors: Nassef Nashaat E. , Shendi Sawsan S. , Saad Abdel-Gawad E. , Harba Nancy M. , Beshay Engy V.N. , Mohamed Asmaa Shams El-Dein , Gouda Marwa A.
Published: May 2024

In the past decade, interest has significantly increased regarding the medicinal and nutritional benefits of pomegranate (Punica granatum) peel. This study examined the effects of using pomegranate peel extract (PGE) alone and in combination with albendazole (ABZ) on ultrastructural and immunological changes in cystic echinococcosis in laboratory-infected mice. Results revealed that the smallest hydatid cyst size and weight (0.48 ± 0.47mm, 0.17 ± 0.18 gm) with the highest drug efficacy (56.2%) was detected in the PGE + ABZ group, which also exhibited marked histopathological improvement. Ultrastructural changes recorded by transmission electron microscopy including fragmentation of the nucleus, glycogen depletion, and multiple lysosomes in vacuolated cytoplasm were more often observed in PGE + ABZ group. IFN-γ levels were significantly increased in the group treated with ABZ, with a notable reduction following PGE treatment, whether administered alone or in combination with ABZ. Thus, PGE enhanced the therapeutic efficiency of ABZ, with improvement in histopathological and ultrastructural changes.
On abstract goals’ perverse effects on proxies: The dynamics of unattainability
Authors: Fernández-Dols José-Miguel
Published: May 2024

Proxies should not be classified as failures or successes because, in most cases, they are impossible translations of abstract, polysemous goals to supposedly univocal concrete measures. The “success” or “failure” of a proxy does not depend on its actual accuracy as a valid indicator of goal attainment, but on a social system's willingness to maintain an illusion of its accomplishment.
It's the biology, stupid! Proxy failures in economic decision making
Authors: Sacco Pier Luigi
Published: May 2024

Utilitarian characterizations of economic decision making fail to capture the complex, conditional, and heterogeneous motivations underlying human behavior as shaped by the predictive, multicriterial drivers of biological regulation. Unless economic models start to acknowledge that humans have bodies and a biology with its own adaptive logic and tradeoffs, economic policies will be systematically exposed to, and systematic generators of, proxy failures.
Language anxiety does not affect the growth of L2 reading achievement: The latent growth curve model approach
Authors: Sparks Richard L. , Alamer Abdullah
Published: May 2024

Second language (L2) anxiety has been proposed to play a causal role in L2 achievement. However, most studies have failed to acknowledge confounding variables that may be relevant to the study of anxiety and L2 achievement or to investigate the causal effect of L2 anxiety using longitudinal data. For these reasons, we investigated the effect of L1 reading achievement, L2 aptitude, and L2 anxiety as covariates on the growth of L2 reading achievement across three time points. We used the latent growth curve model (LGCM) to estimate the growth trajectory of US secondary school students’ L2 reading growth in Spanish (N = 307) over three school years. The findings showed that students’ L1 reading achievement and L2 aptitude strongly and significantly predicted L2 reading achievement growth. However, L2 anxiety did not predict L2 reading achievement growth. Findings suggest that growth in L2 reading achievement depends on the language-related skills used for L1 reading and the language skills that comprise L2 aptitude, but not on anxiety. Similar to past cross-sectional studies, L2 anxiety related only to initial levels of L2 reading achievement, suggesting that anxiety reflects students’ initial experience of L2 reading but not their L2 achievement.
Four-bar linkage reconfigurable robotic wheel: Design, kinematic analysis, and experimental validation for adaptive size modification
Authors: Sandoval-Castro X. Yamile , Muñoz-Gonzalez Sergio , Garcia-Murillo Mario A. , Ferrusca-Monroy Pedro D. , Ruiz-Torres Maxiamiano F.
Published: May 2024

This article presents the development of a robot capable of modifying its size through a wheel reconfiguration strategy. The reconfigurable wheel design is based on a four-bar retractable mechanism that achieves variation of the effective radius of the wheel. A reconfiguration index is introduced based on the number of retractable mechanisms that predicts the radius of configuration according to the number of mechanisms implemented in the wheel. The kinematics of the retractable mechanism is studied to determine the theoretical reconfiguration radius during the transformation process, it is also evaluated numerically with the help of the GeoGebra software, and it is validated experimentally by image analysis using the Tracker software. The transformation process of the robot is investigated through an analysis of forces that consider the wheel in contact with the obstacle, the calculation of the wheel torque and the height of the obstacle to be overcome are presented. On the other hand, the experimental validation of the robot reconfiguration process is presented through the percentage of success shown by the robot to overcome obstacles of 50, 75, 100 and 125 mm. In addition, measurements of energy consumption during the transformation process are reported. Reconfigurable wheels, capable of adapting their size, offer innovative solutions to various challenges across different applications such as robotic exploration and search and rescue missions to industrial settings. Some key issues that these wheels can address include terrain adaptability enhancing a robot’s mobility over uneven surfaces, or obstacles; enhanced robotic design; cost-effective design; space efficiency; and versatility in applications.
Improving national bird population estimates in Europe: insights from comparisons with atlas abundance data
Authors: Herrando Sergi , Fraixedas Sara , Brotons Lluís , Martí David , Staneva Anna , Keller Verena , Voříšek Petr , Burfield Ian J.
Published: May 2024

In Europe, population estimates of breeding birds are produced nationally and are periodically compiled at EU or pan-European scales. Until now, no other source was available to explore the robustness of these estimates. In this study, we compared population sizes reported in the latest edition of the European Red List of Birds (ERLoB) with those produced using data from the second European Breeding Bird Atlas (EBBA2) to assess their consistency and determine parameters behind variability in population estimates that deserve further attention in the future. In general, European population estimates derived from summing local abundance data from EBBA2 were similar to those obtained from ERLoB, although for some species they differed considerably, particularly in those distributed mainly in southern Europe. National population estimates from EBBA2 also did not differ markedly from those in ERLoB. However, we found that EBBA2 provided larger national population sizes than ERLoB for widespread species, suggesting that spatial information is more relevant for properly assessing their population size than for localised species. Our analysis also showed that, in general, population estimates based on robust methodological protocols (e.g. complete counts, statistical inference) contributed to reducing differences between ERLoB and EBBA2 values. Interestingly, EBBA2 and ERLoB estimates were quite similar for species classified in Europe as “Threatened” or “Near Threatened”, whereas the values for “Least Concern” species were consistently different between these two sources. Our results indicate which type of species would benefit from additional efforts to improve national population estimates and their consistency across countries, issues that are of paramount importance for guiding conservation strategies in Europe.
Logical characterizations of algebraic circuit classes over integral domains
Authors: Barlag Timon , Chudigiewitsch Florian , Gaube Sabrina A.
Published: May 2024

We present an adapted construction of algebraic circuits over the reals introduced by Cucker and Meer to arbitrary infinite integral domains and generalize the
$\mathrm{AC}_{\mathbb{R}}$
and
$\mathrm{NC}_{\mathbb{R}}^{}$
classes for this setting. We give a theorem in the style of Immerman’s theorem which shows that for these adapted formalisms, sets decided by circuits of constant depth and polynomial size are the same as sets definable by a suitable adaptation of first-order logic. Additionally, we discuss a generalization of the guarded predicative logic by Durand, Haak and Vollmer, and we show characterizations for the
$\mathrm{AC}_{R}$
and
$\mathrm{NC}_R^{}$
hierarchy. Those generalizations apply to the Boolean
$\mathrm{AC}$
and
$\mathrm{NC}$
hierarchies as well. Furthermore, we introduce a formalism to be able to compare some of the aforementioned complexity classes with different underlying integral domains.
Academic Publishing in Modern Society
Authors: Engwall Lars
Published: May 2024

This article analyses academic publishing in modern society by means of a governance model focusing on three groups of governors: Regulators, Market Actors, and Professions. It demonstrates how these three groups have interacted and how this interaction has put pressure on faculty members to produce publications for top journals. It also points to the strong position of publishers, which leads to high profit margins. The article therefore also discusses different possible measures to change the publishing system.
An ultra-wideband power amplifier designed through a bandwidth expansion strategy
Authors: Xuan Xuefei , Cheng Zhiqun , Hayes Brendan , Zhang Zhiwei , Gong Tingwei , Wu Shenbing , Le Chao
Published: May 2024

A bandwidth expansion strategy for ultra-wideband power amplifiers (PAs) is presented in this letter by adopting a parallel impedance matching architecture. This design strategy can effectively reduce the impedance conversion ratio between the load and the target impedance of the PA, thereby providing a feasible solution for broadband impedance matching. Subsequently, a commercially available 10 W gallium nitride device and a two-stage Wilkinson power divider network are combined to achieve the verification of the proposed theory. The results of the measurement show that within the target frequency band of 0.9–3.9 GHz, 58.5–71.2% of the drain efficiency and 9.1–12 dB of gain can be achieved with a saturated output power of 39.1–42 dBm.
Development and Validation of a General Aviation Risk Perception Scale
Authors: Trabysh Victoria H. , Keebler Joseph R. , Winter Scott R.
Published: May 2024

Abstract: The aim of this study was to develop a psychometric tool for measuring pilot perceptions of risk, with a focus on risk in general aviation (GA) flying. Unlike other objective protocols that pilots adhere to (e.g., checklists), assessing and responding to risk is a subjective task, making it challenging to evaluate. Previous research has developed scales that are either too generalized or have poor psychometric properties (i.e., reliability and validity). Therefore, this effort intended to develop a validated scale utilizing psychometrically sound methods, including literature review, item generation, subject matter expert review, item pool truncation, data collection, and analysis. Results confirmed a statistically valid and reliable 15-item scale – the General Aviation Risk Perception Scale – explicitly for pilots and GA-related risk.
Tidal Heating in a Subsurface Magma Ocean on Io Revisited
Authors: Aygün B. , Čadek O.
Published: May 2024

We investigate the tidal dissipation in Io's hypothetical fluid magma ocean using a new approach based on the solution of the 3D Navier‐Stokes equations. Our results indicate that the presence of a shallow magma ocean on top of a solid, partially molten layer leads to an order of magnitude increase in dissipation at low latitudes. Tidal heating in Io's magma ocean does not correlate with the distribution of hot spots, and is maximum for an ocean thickness of about 1 km and a viscosity of less than 104 Pa s. Due to the Coriolis effect, the k2 Love number can depend on the harmonic order. We show that the analysis of k2 may not reveal the presence of a fluid magma ocean if the ocean thickness is less than 2 km. If the fluid layer is thicker than 2 km, k20 ≈ k22/2 ≈ 0.7.
Feasibility and safety of the discontinuation of systemic immunosuppressive treatment after single-unit cord blood transplantation in adults
Authors: Konuma Takaaki , Monna-Oiwa Maki , Kato Seiko , Isobe Masamichi , Nannya Yasuhito , Takahashi Satoshi
Published: May 2024

We retrospectively evaluated the incidence, factors, and clinical outcomes of the discontinuation of immunosuppressive treatment (IST) after single-unit unrelated cord blood transplantation (CBT) in adults receiving cyclosporine-based graft-versus-host disease (GVHD) prophylaxis at our institute. Among the 309 patients who achieved engraftment, 247 were able to discontinue IST with a median follow-up of 121 months for survivors. The cumulative incidence of the discontinuation of IST was 46.2% at 180 days, 72.8% at 2 years, and 79.3% at 5 years post-CBT. In the multivariate analysis, discontinuation of IST after CBT was significantly associated with the requirement for steroid therapy (hazard ratio [HR]: 0.46; P < 0.001) and the recent calendar year of CBT (HR: 1.79; P < 0.001). In the conditional landmark analysis at 180 days, discontinuation of IST was not associated with the development of extensive chronic GVHD (HR: 1.00; P = 0.989), non-relapse mortality (HR: 0.49; P = 0.122), relapse (HR: 1.46; P = 0.388), or overall survival (HR: 1.91; P = 0.065). Our data showed that successful discontinuation of IST is common after single-unit CBT in adults. Discontinuation of IST did not affect subsequent outcomes, suggesting that discontinuation of IST is both feasible and safe in adults undergoing single-unit CBT.
Hypoxia- and Postirradiation reoxygenation-induced HMHA1/ARHGAP45 expression contributes to cancer cell invasion in a HIF-dependent manner
Authors: Lee Peter W. T. , Suwa Tatsuya , Kobayashi Minoru , Yang Hui , Koseki Lina R. , Takeuchi Satoshi , Chow Christalle C. T. , Yasuhara Takaaki , Harada Hiroshi
Published: May 2024

Background

Cancer cells in severely hypoxic regions have been reported to invade towards tumour blood vessels after surviving radiotherapy in a postirradiation reoxygenation- and hypoxia-inducible factor (HIF)-dependent manner and cause recurrence. However, how HIF induces invasiveness of irradiated and reoxygenated cancer cells remains unclear.

Methods

Here, we identified human minor histocompatibility antigen 1 (HMHA1), which has been suggested to function in cytoskeleton dynamics and cellular motility, as a responsible factor and elucidated its mechanism of action using molecular and cellular biology techniques.

Results

HMHA1 expression was found to be induced at the transcription initiation level in a HIF-dependent manner under hypoxia. Boyden chamber invasion assay revealed that the induction of HMHA1 expression is required for the increase in invasion of hypoxic cancer cells. Reoxygenation treatment after ionising radiation in vitro that mimics dynamic changes of a microenvironment in hypoxic regions of tumour tissues after radiation therapy further enhanced HMHA1 expression and invasive potential of HMHA1 wildtype cancer cells in ROS- and HIF-dependent manners, but not of HMHA1 knockout cells.

Conclusion

These results together provide insights into a potential molecular mechanism of the acquisition of invasiveness by hypoxic cancer cells after radiotherapy via the activation of the ROS/HIF/HMHA1 axis.
Actionability and familial uptake following opportunistic genomic screening in a pediatric cancer cohort
Authors: Hammer-Hansen Sophia , Stoltze Ulrik , Bartels Emil , Hansen Thomas van Overeem , Byrjalsen Anna , Tybjærg-Hansen Anne , Juul Klaus , Schmiegelow Kjeld , Tfelt Jacob , Bundgaard Henning , Wadt Karin , Diness Birgitte Rode
Published: May 2024

The care for patients with serious conditions is increasingly guided by genomic medicine, and genomic medicine may equally transform care for healthy individual if genomic population screening is implemented. This study examines the medical impact of opportunistic genomic screening (OGS) in a cohort of patients undergoing comprehensive genomic germline DNA testing for childhood cancer, including the impact on their relatives. Medical actionability and uptake after cascade testing in the period following disclosure of OGS results was quantified. A secondary finding was reported to 19/595 (3.2%) probands primarily in genes related to cardiovascular and lipid disorders. After a mean follow up time of 1.6 years (Interquartile range (IQR): 0.57-1.92 yrs.) only 12 (63%) of these variants were found to be medically actionable. Clinical follow up or treatment was planned in 16 relatives, and as in the probands, the prescribed treatment was primarily betablockers or cholesterol lowering therapy. No invasive procedures or implantation of medical devices were performed in probands or relatives, and no reproductive counseling was requested. After an average of 1.6 years of follow-up 2.25 relatives per family with an actionable finding had been tested. This real-world experience of OGS grants new insight into the practical implementation effects and derived health care demands of genotype-first screening. The resulting health care effect and impact on demand for genetic counseling and workup in relatives extends beyond the effect in the probands.
Transcriptomic evidence of erythropoietic adaptation from the International Space Station and from an Earth-based space analog
Authors: Trudel Guy , Stratis Daniel , Rocheleau Lynda , Pelchat Martin , Laneuville Odette
Published: May 2024

Space anemia affects astronauts and the underlying molecular alterations remain unknown. We evaluated the response of erythropoiesis-modulating genes to spaceflight through the analysis of leukocyte transcriptomes from astronauts during long-duration spaceflight and from an Earth model of microgravity. Differential expression analysis identified 50 genes encoding ribosomal proteins with reduced expression at the transition to bed rest and increased during the bed rest phase; a similar trend was observed in astronauts. Additional genes associated with anemia (15 genes), erythrocyte maturation (3 genes), and hemoglobin (6 genes) were down-regulated during bed rest and increased during reambulation. Transcript levels of the erythropoiesis transcription factor GATA1 and nine of most enriched erythrocyte proteins increased at reambulation after bed rest and at return to Earth from space. Dynamic changes of the leukocyte transcriptome composition while in microgravity and during reambulation supported an erythropoietic modulation accompanying the hemolysis of space anemia and of immobility-induced anemia.
Thermal evolution of spin excitations in honeycomb Ising antiferromagnetic FePSe3
Authors: Chen Lebing , Teng Xiaokun , Hu Ding , Ye Feng , Granroth Garrett E. , Yi Ming , Chung Jae-Ho , Birgeneau Robert J. , Dai Pengcheng
Published: May 2024

We use elastic and inelastic neutron scattering (INS) to study the antiferromagnetic (AF) phase transitions and spin excitations in the two-dimensional (2D) zig-zag antiferromagnet FePSe3. By determining the magnetic order parameter across the AF phase transition, we conclude that the AF phase transition in FePSe3 is first-order in nature. In addition, our INS measurements reveal that the spin waves in the AF ordered state have a large easy-axis magnetic anisotropy gap, consistent with an Ising Hamiltonian, and possible biquadratic magnetic exchange interactions. On warming across TN, we find that dispersive spin excitations associated with three-fold rotational symmetric AF fluctuations change into FM spin fluctuations above TN. These results suggest that the first-order AF phase transition in FePSe3 may arise from the competition between C3 symmetric AF and C1 symmetric FM spin fluctuations around TN, in place of a conventional second-order AF phase transition.
Linking CRISPR–Cas9 double-strand break profiles to gene editing precision with BreakTag
Authors: Longo Gabriel M. C. , Sayols Sergi , Kotini Andriana G. , Heinen Sabine , Möckel Martin M. , Beli Petra , Roukos Vassilis
Published: May 2024

Cas9 can cleave DNA in both blunt and staggered configurations, resulting in distinct editing outcomes, but what dictates the type of Cas9 incisions is largely unknown. In this study, we developed BreakTag, a versatile method for profiling Cas9-induced DNA double-strand breaks (DSBs) and identifying the determinants of Cas9 incisions. Overall, we assessed cleavage by SpCas9 at more than 150,000 endogenous on-target and off-target sites targeted by approximately 3,500 single guide RNAs. We found that approximately 35% of SpCas9 DSBs are staggered, and the type of incision is influenced by DNA:gRNA complementarity and the use of engineered Cas9 variants. A machine learning model shows that Cas9 incision is dependent on the protospacer sequence and that human genetic variation impacts the configuration of Cas9 cuts and the DSB repair outcome. Matched datasets of Cas9 and engineered variant incisions with repair outcomes show that Cas9-mediated staggered breaks are linked with precise, templated and predictable single-nucleotide insertions, demonstrating that a scission-based gRNA design can be used to correct clinically relevant pathogenic single-nucleotide deletions.
Long-term weight loss effects of semaglutide in obesity without diabetes in the SELECT trial
Authors: Ryan Donna H. , Lingvay Ildiko , Deanfield John , Kahn Steven E. , Barros Eric , Burguera Bartolome , Colhoun Helen M. , Cercato Cintia , Dicker Dror , Horn Deborah B. , Hovingh G. Kees , Jeppesen Ole Kleist , Kokkinos Alexander , Lincoff A. Michael , Meyhöfer Sebastian M. , Oral Tugce Kalayci , Plutzky Jorge , van Beek André P. , Wilding John P. H. , Kushner Robert F.
Published: May 2024

In the SELECT cardiovascular outcomes trial, semaglutide showed a 20% reduction in major adverse cardiovascular events in 17,604 adults with preexisting cardiovascular disease, overweight or obesity, without diabetes. Here in this prespecified analysis, we examined effects of semaglutide on weight and anthropometric outcomes, safety and tolerability by baseline body mass index (BMI). In patients treated with semaglutide, weight loss continued over 65 weeks and was sustained for up to 4 years. At 208 weeks, semaglutide was associated with mean reduction in weight (−10.2%), waist circumference (−7.7 cm) and waist-to-height ratio (−6.9%) versus placebo (−1.5%, −1.3 cm and −1.0%, respectively; P < 0.0001 for all comparisons versus placebo). Clinically meaningful weight loss occurred in both sexes and all races, body sizes and regions. Semaglutide was associated with fewer serious adverse events. For each BMI category (<30, 30 to <35, 35 to <40 and ≥40 kg m−2) there were lower rates (events per 100 years of observation) of serious adverse events with semaglutide (43.23, 43.54, 51.07 and 47.06 for semaglutide and 50.48, 49.66, 52.73 and 60.85 for placebo). Semaglutide was associated with increased rates of trial product discontinuation. Discontinuations increased as BMI class decreased. In SELECT, at 208 weeks, semaglutide produced clinically significant weight loss and improvements in anthropometric measurements versus placebo. Weight loss was sustained over 4 years. ClinicalTrials.gov identifier: NCT03574597.
Brain clearance is reduced during sleep and anesthesia
Authors: Miao Andawei , Luo Tianyuan , Hsieh Bryan , Edge Christopher J. , Gridley Morgan , Wong Ryan Tak Chun , Constandinou Timothy G. , Wisden William , Franks Nicholas P.
Published: May 2024

It has been suggested that the function of sleep is to actively clear metabolites and toxins from the brain. Enhanced clearance is also said to occur during anesthesia. Here, we measure clearance and movement of fluorescent molecules in the brains of male mice and show that movement is, in fact, independent of sleep and wake or anesthesia. Moreover, we show that brain clearance is markedly reduced, not increased, during sleep and anesthesia.
Securing Internet-of-Medical-Things networks using cancellable ECG recognition
Authors: El-Moneim Kabel Samia A. , El-Banby Ghada M. , Abou Elazm Lamiaa A. , El-Shafai Walid , El-Bahnasawy Nirmeen A. , El-Samie Fathi E. Abd , Elazm Atef Abou , Siam Ali I. , Abdelhamed Mohamed A.
Published: May 2024

Reinforcement of the Internet of Medical Things (IoMT) network security has become extremely significant as these networks enable both patients and healthcare providers to communicate with each other by exchanging medical signals, data, and vital reports in a safe way. To ensure the safe transmission of sensitive information, robust and secure access mechanisms are paramount. Vulnerabilities in these networks, particularly at the access points, could expose patients to significant risks. Among the possible security measures, biometric authentication is becoming a more feasible choice, with a focus on leveraging regularly-monitored biomedical signals like Electrocardiogram (ECG) signals due to their unique characteristics. A notable challenge within all biometric authentication systems is the risk of losing original biometric traits, if hackers successfully compromise the biometric template storage space. Current research endorses replacement of the original biometrics used in access control with cancellable templates. These are produced using encryption or non-invertible transformation, which improves security by enabling the biometric templates to be changed in case an unwanted access is detected. This study presents a comprehensive framework for ECG-based recognition with cancellable templates. This framework may be used for accessing IoMT networks. An innovative methodology is introduced through non-invertible modification of ECG signals using blind signal separation and lightweight encryption. The basic idea here depends on the assumption that if the ECG signal and an auxiliary audio signal for the same person are subjected to a separation algorithm, the algorithm will yield two uncorrelated components through the minimization of a correlation cost function. Hence, the obtained outputs from the separation algorithm will be distorted versions of the ECG as well as the audio signals. The distorted versions of the ECG signals can be treated with a lightweight encryption stage and used as cancellable templates. Security enhancement is achieved through the utilization of the lightweight encryption stage based on a user-specific pattern and XOR operation, thereby reducing the processing burden associated with conventional encryption methods. The proposed framework efficacy is demonstrated through its application on the ECG-ID and MIT-BIH datasets, yielding promising results. The experimental evaluation reveals an Equal Error Rate (EER) of 0.134 on the ECG-ID dataset and 0.4 on the MIT-BIH dataset, alongside an exceptionally large Area under the Receiver Operating Characteristic curve (AROC) of 99.96% for both datasets. These results underscore the framework potential in securing IoMT networks through cancellable biometrics, offering a hybrid security model that combines the strengths of non-invertible transformations and lightweight encryption.
Climate change as observed through the IMS radionuclide station in Spitzbergen
Authors: Kuśmierczyk-Michulec Jolanta , Baré Jonathan
Published: May 2024

The International Monitoring System (IMS), installed and maintained by the Comprehensive Nuclear-Test-Ban Treaty Organization (CTBTO) with the support of States Signatories, is a global system of monitoring stations based on four complementary technologies: seismic, hydroacoustic, infrasound and radionuclide. One of the IMS radionuclide stations is located in Spitzbergen, the largest island of the Norwegian Svalbard Archipelago, which borders the Barents Sea and the Northern Atlantic Ocean. It has been demonstrated that signs of climate change are particularly noticeable in that region. As many other radionuclides observed in environmental measurements, 212Pb is always observed at IMS stations, in varying quantities. This is also the case for the IMS station RN49, Spitzbergen, where it can be demonstrated that the average concentration of the measured lead 212Pb increases. This is observable specifically October through December. This paper demonstrates the asset of IMS data to study climate change effects. Our conclusions are supported by global temperature anomaly data from NOAA’s Global Surface Temperature Analysis, covering the period 1850 to 2023.
Novel sustainable steel fiber reinforced preplaced aggregate concrete incorporating Portland limestone cement
Authors: Saleh Majed Ali , Su Zhihao , Zhang Ji
Published: May 2024

This study proposes a novel approach by adding Portland limestone cement (PLC) to preplaced aggregate steel fiber reinforced concrete (PASFRC) to create a sustainable concrete that minimizes CO2 emissions and cement manufacturing energy usage. The method involves injected a flowable grout after premixing and preplacing steel-fibers and aggregates in the formwork. This study evaluates the mechanical properties of a novel sustainable concrete that uses PLC and steel fibers. To achieve the intended objective, long and short end-hooked steel fibers of 1%, 2%, 3%, and 6% were incorporated in PASFRC. Also, Analysis of variance (ANOVA) was used to examine the data. Results indicated that PLC and higher fiber doses increased the mechanical properties of PAC. At 90 days, PASFRC mixtures containing 6% long steel fibers demonstrated superior compressive, tensile, and flexural strengths, registering the highest values of 49.8 MPa, 7.7 MPa, and 10.9 MPa, respectively and differed by 188%, 166%, and 290%, respectively from fiberless PAC. The study confirmed the suitability and effectiveness of using PLC with steel fibers in PAC which significantly improved the mechanical properties of PASFRC. This was verified through analytical analysis and new empirical equations were proposed to predict the mechanical properties of PASFRC.
Archaeobotanical evidence supports indigenous cucurbit long-term use in the Mesoamerican Neotropics
Authors: Domic Alejandra I. , VanDerwarker Amber M. , Thakar Heather B. , Hirth Kenneth , Capriles José M. , Harper Thomas K. , Scheffler Timothy E. , Kistler Logan , Kennett Douglas J.
Published: May 2024

The squash family (Cucurbitaceae) contains some of the most important crops cultivated worldwide and has played an important ecological, economic, and cultural role for millennia. In the American tropics, squashes were among the first cultivated crop species, but little is known about how their domestication unfolded. Here, we employ direct radiocarbon dating and morphological analyses of desiccated cucurbit seeds, rinds, and stems from El Gigante Rockshelter in Honduras to reconstruct human practices of selection and cultivation of Lagenaria siceraria, Cucurbita pepo, and Cucurbita moschata. Direct radiocarbon dating indicates that humans started using Lagenaria and wild Cucurbita starting ~ 10,950 calendar years before present (cal B.P.), primarily as watertight vessels and possibly as cooking and drinking containers. A rind directly dated to 11,150–10,765 cal B.P. represents the oldest known bottle gourd in the Americas. Domesticated C. moschata subsequently appeared ~ 4035 cal B.P., followed by domesticated C. pepo ~ 2190 cal B.P. associated with increasing evidence for their use as food crops. Multivariate statistical analysis of seed size and shape show that the archaeological C. pepo assemblage exhibits significant variability, representing at least three varieties: one similar to present-day zucchini, another like present-day vegetable marrow, and a native cultivar without modern analogs. Our archaeobotanical data supports the hypothesis that Indigenous cucurbit use started in the Early Holocene, and that agricultural complexity during the Late Holocene involved selective breeding that encouraged crop diversification.
Image analysis and teaching strategy optimization of folk dance training based on the deep neural network
Authors: Li Zhou
Published: May 2024

To improve the recognition effect of the folk dance image recognition model and put forward new suggestions for teachers’ teaching strategies, this study introduces a Deep Neural Network (DNN) to optimize the folk dance training image recognition model. Moreover, a corresponding teaching strategy optimization scheme is proposed according to the experimental results. Firstly, the image preprocessing and feature extraction of DNN are optimized. Secondly, classification and target detection models are established to analyze the folk dance training images, and the C-dance dataset is used for experiments. Finally, the results are compared with those of the Naive Bayes classifier, K-nearest neighbor, decision tree classifier, support vector machine, and logistic regression models. The results of this study provide new suggestions for teaching strategies. The research results indicate that the optimized classification model shows a significant improvement in classification accuracy across various aspects such as action complexity, dance types, movement speed, dance styles, body dynamics, and rhythm. The accuracy, precision, recall, and F1 scores have increased by approximately 14.7, 11.8, 13.2, and 17.4%, respectively. In the study of factors such as different training images, changes in perspective, lighting conditions, and noise interference, the optimized model demonstrates a substantial enhancement in recognition accuracy and robustness. These findings suggest that, compared to traditional models, the optimized model performs better in identifying various dances and movements, enhancing the accuracy and stability of classification. Based on the experimental results, strategies for optimizing the real-time feedback and assessment mechanism in folk dance teaching, as well as the design of personalized learning paths, are proposed. Therefore, this study holds the potential to be applied in the field of folk dance, promoting the development and innovation of folk dance education.
Computer vision models enable mixed linear modeling to predict arbuscular mycorrhizal fungal colonization using fungal morphology
Authors: Zhang Shufan , Wu Yue , Skaro Michael , Cheong Jia-Hwei , Bouffier-Landrum Amanda , Torrres Isaac , Guo Yinping , Stupp Lauren , Lincoln Brooke , Prestel Anna , Felt Camryn , Spann Sedona , Mandal Abhyuday , Johnson Nancy , Arnold Jonathan
Published: May 2024

The presence of Arbuscular Mycorrhizal Fungi (AMF) in vascular land plant roots is one of the most ancient of symbioses supporting nitrogen and phosphorus exchange for photosynthetically derived carbon. Here we provide a multi-scale modeling approach to predict AMF colonization of a worldwide crop from a Recombinant Inbred Line (RIL) population derived from Sorghum bicolor and S. propinquum. The high-throughput phenotyping methods of fungal structures here rely on a Mask Region-based Convolutional Neural Network (Mask R-CNN) in computer vision for pixel-wise fungal structure segmentations and mixed linear models to explore the relations of AMF colonization, root niche, and fungal structure allocation. Models proposed capture over 95% of the variation in AMF colonization as a function of root niche and relative abundance of fungal structures in each plant. Arbuscule allocation is a significant predictor of AMF colonization among sibling plants. Arbuscules and extraradical hyphae implicated in nutrient exchange predict highest AMF colonization in the top root section. Our work demonstrates that deep learning can be used by the community for the high-throughput phenotyping of AMF in plant roots. Mixed linear modeling provides a framework for testing hypotheses about AMF colonization phenotypes as a function of root niche and fungal structure allocations.