bluuebunny/crossref_metadata_2025 huggingface dataset:
Protective effect of tretinoin derivative and TXNRD1 protein on streptozotocin induced gestational diabetes via an age-rage signaling-pathway
Authors: Wang Wensheng , Wang Lin
Published: December 2023

Background: In the present study effect of tretinoin derivative was investigated on the pathogenesis of gestational diabetes mellitus (GDM) in mice model in vivo. Materials and Methods: Diabetes was induced in mice by injecting Streptozotocin (STZ) for 5consecutive days at a dose of 65 mg/kg body weight through the intraperitoneal route. Tretinoin derivative was given to the mice at 0.12 and 0.25 mg/kg doses through gavage in normal saline alternately for one week after STZ injection.Results: The results demonstrated that tretinoin derivative administration to the diabetic mice significantly (P<0.05) alleviated the blood FBG and FINS levels. Administration of tretinoin derivative to the diabetic mice significantly (P<0.05) promoted the blood HDL level and alleviated TC and TG levels. The administration of tretinoin derivative to the diabetic mice significantly (P<0.05) alleviated the CRP, IL-6and TNF-α production in pancreatic tissues. Tretinoin derivative administration to the diabetic mice significantly (P<0.05) elevated the SOD activity, and CAT level and lowered the MDA level in pancreatic tissues. The TXNRD1 expression in diabetic mice was comparable to that in the normal group after administration of tretinoin derivativeat the dose of 0.25 mg/kg dose. In silico data demonstrated that tretinoin derivativeinteracts with TXNRD1 protein with the binding affinity ranging from –10 to 9.4 kcal/ mol. Conclusion: In conclusion, tretinoin derivative administration effectively regulated streptozotocin-induced changes in fasting blood glucose, insulin level, high-density lipid level and triglyceride level in diabetic mice in vivo. The streptozotocin-induced excessive production of C-reactive protein and inflammatory cytokines was also down-regulated in diabetic mice on administration of tretinoin derivative. Therefore, tretinoin derivative can be investigated further as a therapeutic agent for the treatment of gestational diabetes mellitus.
The regional poverty: Generation aspect
Authors:   Saratov State University, Mokhnatkina Ksenia V.
Published: December 2023

The article presents the results of an empirical sociological study conducted in 2022 in Saratov using the questionnaire method and dedicated to poverty. The volume of the quota-territorial sample amounted to 626 respondents. It was revealed that the middle generation was more likely to talk about absolute poverty, the younger – about relative poverty. Today, the majority of Saratov residents link poverty with an income of 8–12,000 rubles. Every fourth of them felt poverty at the beginning of their independent life path and the same number, mainly of the middle generation, at the time of the survey are in a situation of poverty. They feel more deprived in all areas of everyday life, especially on vacation. The dynamics of the assessment of the material situation indicates a relatively successful stable improvement in the situation of young people, and somewhat less favorable multidirectional vectors of change in the middle generation. Among young people, they more often talked about the risk of losing their jobs, low wages, and losing their breadwinner. Among the middle generation, the fear of illness and over-indebtedness are more common. For residents of the city of Saratov, the main objective factors of poverty were low wages (68.5%), unemployment (50.5%), insufficient state support (44.0%). Along with this, the subject characteristics that contribute to poverty are highlighted: laziness, alcoholism, low educational level, drug addiction, loss of health, over-indebtedness and loss of breadwinner. In other words, Saratov residents are more inclined to blame the state and its policies for poverty, not forgetting about the subjective characteristics of individuals. Young people are more optimistic than the average generation about overcoming poverty. 6.7% of Saratov residents leave the town for other areas to earn money, mainly young people (6.9%). 20.0% of the population, mostly the middle generation, still plan to do it. Most often, people leave for work to capital cities, less often - in other regions. The majority of the Saratov population, especially the middle generation, rather negatively evaluate the effectiveness of the strategy to overcome poverty in the region.
Basic scholarly interpretations of new markers of political identification of youth in modern Russia
Authors:   Saratov State University, Vilkov Alexander A.
Published: December 2023

The article examines the main trends in understanding political identification of the main groups of Russian youth in the last year and a half. Based on the analysis of the latest scholarly literature on this issue, it has been revealed that the attention of researchers continues to be attracted by the development of a methodology for analyzing various structures of youth identity, the justification of new types of their typology, the possibilities of combining various identification matrices for a more accurate correlation of the ideological, worldview and activity positioning of representatives of the younger generation. In scientific discourse, the position of supporters of a liberal interpretation of civic identity based on the justification of the priority of civil rights and individual freedoms has significantly weakened. The position whose supporters actually equate civic identity and national identity acquires dominant significance. This is due, first of all, to the official goal of introducing into the mass consciousness of young people an understanding of the social significance of the state and its functionality and the need to stimulate the corresponding active civic position of each individual in protecting the interests of the state and society as a whole. It is concluded that most researchers do not touch upon the specifics of identifying various groups of Russian youth in relation to the special military operation in Ukraine. On the one hand, this is understandable, given the complexity of the situation and the ambiguous possible consequences regarding any critical assessments on the part of researchers. On the other hand, there is a need for an objective understanding of new lines of demarcation, which, in terms of their motivational significance, are often ranked at a higher level than the traditional party-ideological and worldview preferences of Russian youth. Understanding these identification markers is the most important scientific task in theoretical and practical senses.
Threats to human security in Latin America
Authors:   Military University named after Prince Alexander Nevsky of the Russian Defense Ministry, Moscow State Linguistic University, Smirnova Anastasia S.
Published: December 2023

Like any other region of the world Latin America is a subject to threats that negatively affect the standard of living of people. The author identifies and analyzes the main economic, social, political, and environmental threats of the region, referring to the documents of international organizations such as the UN, the World Bank, Human Rights Watch and experts studying the problems. The author notes that the immediate economic threat to human security arises from a drop in production, loss of income and rising unemployment, which leads to a significant increase in poverty and a decrease in citizens’ confidence in the future. Against the backdrop of global crises, the World Bank forecasts a modest increase in the GDP of countries in the coming years. The author identifies three social groups that are most vulnerable to threats to human security: migrants, indigenous people, women, and children. A common problem for the region is the high percentage of cases of violence that also come from the authorities. The main threat to the political security of citizens is the weakness of democracies, since this political system in the region has existed for about forty years and is not yet as developed as in other regions of the world. The high level of corruption among officials aggravates the situation in the country, which often leads to rallies and strikes throughout the region. Among the transnational threats to human security, the author notes terrorism and organized crime, including money laundering and drug trafficking, as well as trafficking in short-barreled weapons. These threats pose a direct danger to people’s lives. Against the background of deforestation of tropical forests, the threat to environmental security is extremely acute. The danger is that deforestation leads to the deprivation of indigenous peoples of their habitat, which directly affects the human security of the region.
Medieval London during the plague (1348–1351): Some aspects of social life
Authors:   Saratov State University, Leshtaev Dmitry V.
Published: December 2023

The article examines certain aspects of the social life of the City during the period of the plague (1348–1351) based on the documentation of the London Magistrate. It is shown that the Black Death dealt the most severe blow to the capital’s guilds, depriving them of workers and temporarily disorganizing production, which affected both the quality of manufactured products and relations inside trade and craft corporations, contributing to their further decline. Being unable to cope with the growth of social activity of journeymen, apprentices and servants, the masterswere forced to appeal to the authority of the City administration, demanding from it theconfirmation of previously established restrictive measures. Another important aspect of everyday life in London was overcoming such consequences of the crisis as the growth of crime and the restoration of shaken public mores, which were also fought through attempts at greater regulation and prohibitions. However, these measures did not bring tangible results.
“Annales Regni Henrici Septimi” (1504–1505, 1507–1508) by Bernard André: History, Propaganda or Myth-creation?
Authors:   Nizhny Novgorod State Agrotechnological University, Kiryukhin Dmitriy V.
Published: December 2023

The article analyzes the so-called “Annales Regni Henrici Septimi” (records of the twentieth and twenty-third years of the reign of the founder of the Tudor dynasty), written by the court poet and royal historiographer Bernard André. Created after the completion of “De Vita atque Gestis Henrici Septimi Historia”, it may have been intended by the author as a draft for a future similar historical work and contain many important details, although due to circumstances it never took the form of a completed work.
“New Eastern Policy” of Willy Brandt and Bundeswehr in 1969–1974
Authors:   Lomonosov Moscow State University, Rodin Denis V.
Published: December 2023

The article based on archival and published materials analyses the attitude of the members of the higher and lower structures of the Bundeswehr to the “new eastern policy” of Chancellor Willy Brandt and the influence of the latter on the development of the armed forces of West Germany in 1969–1974. It is demonstrated that privates and junior officers supported the foreign policy course of W. Brandt on detente in relations with the socialist bloc. At the same time it is shown that the high command of the Bundeswehr emphasized loyalty to the North Atlantic Alliance in their documents and used the principles of the “new eastern policy” to strengthen the positions of the Federal Republic of Germany in NATO.
The influence of internal processes on the formation of Moldova’s foreign policy in the first years of independence
Authors:   Saratov State University, Golovchenko Dmitry P.
Published: December 2023

The article examines the main internal political processes in Moldova at the time of the collapse of the USSR and the republic’s independence. The author highlights the features of the formation of the Moldovan statehood and their influence on the formation of the foreign policy course of the young state. The researcher analyzes the process of Moldova’s inclusion in the system of international relations and joining the main international institutions.
Social Actors and the Language of Othering: A Corpus-Assisted Analysis of the Representation of Covid-19 in Selected Western and Asian English Newspapers
Authors: Theng Theng (Andrine) Ong
Published: December 2023

As of May 2021, the Covid-19 pandemic has caused approximately 3.5 million deaths and 168 million confirmed cases worldwide. Unfortunately, this crisis has not only resulted in a devastating loss of human life but has also given rise to racism, national insecurity, and general xenophobia. This phenomenon can be understood through the concept of ”othering,” which refers to the exclusion of individuals or entire groups based on their ascribed or enacted identities. This study aims to investigate how social actors are constructed by selected Western and Asian English newspapers in relation to Covid-19. Specifically, it seeks to examine whether language of othering is used by different English users (West vs. Asia, inner circle vs. outer circle) in representing the 2020’s deadliest pandemic. To achieve this, the researcher has custom-collected six different newspapers: New Straits Times (Malaysia), The Straits Times (Singapore), Philippines Daily Inquirer (Philippines), The New York Times (US), The Guardian (UK), and The Australian (Australia). A simple corpus query language is used to analyze common nouns in the corpus, focusing on proper nouns and possessive nouns, which will be ranked by frequency. The semantic preference of the most frequent nomination strategy for social actors will be further explored through tagging and categorization of collocates. This study aims to reveal if any social actors were dehumanized or discriminated against through the language used in relation to Covid-19 across the selected Western and Asian newspapers.
Keywords: Covid-19, othering, newspapers, social actors, corpus
Why Purchase Premium in Freemium Online Games: The Self Determination Theory Perspective
Authors: Hussain Ali , Ting Ding Hooi , Mazhar Muhammad
Published: December 2023

After the rise of the freemium business model, the video games industry emerged as a popular source of entertainment in Malaysia. In this modern free game model, virtual content trading is considered a great source of revenue generation for game developers and publishers. Millions of players around the world participate in this activity and purchase virtual items. In this study, we focus on exploring the motives of Malaysian youth for purchasing these in-game virtual products. By employing purposive sampling, qualitative data were collected by means of conducting in-depth interviews with game players who purchase virtual products. This study explored seven important factors: the desire for uniqueness, the desire for dominance, the desire for skillfulness, social interaction, the desire for freedom, social affiliation, and enjoyment, which strongly influence Malaysian players’ behavior toward in-game content consumption during video game playing. Gamers and game developers can benefit from the findings of the present study to customize the in-game virtual product design strategies as per the expectations of respondents.
Keywords: free-to-play, video games, freemium, virtual purchasing, purchase intention
Digitalization, Sustainability and Development in Business. Business Intelligence - The Innovative Solutions for Business Sustainability, Equality, and Green Initiatives of Long-Term Organisational Performance
Authors: Abdul Jalil Nasir , Alam Khan Parvez , Kashif Shad Muhammad
Published: December 2023

Business Intelligence (BI) encompasses a suite of strategies, processes, applications, and technologies that convert raw data into valuable insights for business analysis. By aiding in informed decision-making, BI empowers organizations to enhance their competitive edge and streamline internal operations. It not only uncovers new prospects but also refines customer service and bolsters profitability. Through historical, real-time, and predictive perspectives on business operations, BI facilitates well-informed choices. Leveraging BI tools, businesses dissect consumer behavior, detect trends, and devise potent marketing tactics. BI amplifies comprehension of customers, rivals, and markets, leading to astute decisions that foster profitability. This study amassed data via a survey of 162 IT managers in multinational corporations within Malaysia. Employing partial least squares (PLS) through SmartPLS software, the analysis reveals that BI, along with its insights, contributes to effective management practices. Notably, the information requisites may shift based on the balance between uncertainty and ambiguity in an organization’s practices. Nevertheless, the research gap remains concerning the relationship between BI, its significance, and business performance.
Keywords: business intelligence, data analytics, data mining, big data
Aquaculture Resilience: Empowering Food Security through IoT Based People's Farm Robots
Authors: Tony Lim Abdullah Muhammad Ridhuan , Ali Imron Mochamad , Priyadi Unggul
Published: December 2023

The COVID-19 pandemic starkly revealed the vulnerability of global food systems, prompting a pressing call for sustainable and resilient practices. This conceptual paper forms an integral part of a comprehensive study aimed at investigating the pivotal role of technological and sustainable solutions in surmounting pandemic-induced challenges and attaining vital food security objectives. Specifically, this conceptual paper delves into the possibilities inherent in cloud-based management, robotics, and circular economy principles, focusing on their potential to bolster food security. To this end, the paper proposes the implementation of an ’IoT based Farm robot’ to enhance aquaculture resilience in Yogyakarta, Indonesia – an apt locale renowned for its vibrant community and agricultural traditions. Leveraging cloud technology, the paper explores the remote management and monitoring of fishponds, thereby optimizing resource utilization and elevating overall productivity. Through the integration of robotics, the automation and precision introduced to fish farming processes serve to lessen reliance on manual labor. Furthermore, the incorporation of circular economy principles underpins sustainable practices, minimizing waste and maximizing the efficiency of resources. By harnessing the synergy of cloud-based management, robotics, and circular economy principles, this conceptual paper introduces a solution that empowers local communities to both navigate the current pandemic crisis and foster enduring aquaculture resilience. The discourse presented within this paper holds valuable implications for policymakers, researchers, and practitioners invested in aquaculture and food security. Moreover, it contributes to the wider conversation concerning sustainable food systems, offering a pathway to cultivating a more secure and resilient future for aquaculture in Yogyakarta and beyond, even amidst pandemics and other disruptive occurrences.
Keywords: food security, post pandemic, fishpond, robot, cloud, IoT
FPT HCM University Parental Attitudes and Behavior Towards their Children's ``Coming Out''
Authors: Thuy Phuong Nguyen Quoc , Van Hoan Hoang , Ngoc Ky Anh Nguyen , Duy Long Nguyen
Published: December 2023

The research team carried out a study of parental’ attitudes and behaviors towards their children’s ”coming-out” and gender identity. The study was conducted in Ho Chi Minh City in Vietnam with a group of respondents who are parents of the FPT students. The study was conducted through quantitative methods using questionnaires modified from previous qualitative studies of the researchers. The results show that the group of respondents had low rates of shock or devastation because of their children’s sexual orientation, but they still had a worried attitude. While their behavior is largely non-violent towards their children, they still try to encourage their children to conform to the biological sex they were born with. Parents are also more inclined to accept their children’s sexual orientation if society and its laws accept it. The research results have and will contribute to the implementation of many campaigns and activities related to the topic of LGBT parents and children.
Keywords: parents, students, attitude, behavior, LGBT, coming out, FPT HCM university
Unraveling Farmers' Purchasing Behavior of Solar Water Pumps Using the Theory of Planned Behavior
Authors: Sharma Neetu , Kumari R Oum
Published: December 2023

India is an agricultural country with hottest temperature and moderate humidity, where it is believed that some states receive the maximum solar energy, one of them is the state of Rajasthan. The need for power has expanded over the past few decades’ which is leading to significant increase in environmental degradation as even today, more than 70% of energy needs is fulfilled from fossil fuels. Higher dependence is resulting in higher cost and environmental degradation. Implementing solar pumps cannot only help us to overcome energy deficits but also increase agricultural productivity which help us to reduce pollution produced by thermal and diesel sources. The present study is based on first-hand information gathered from 498 farmers from five blocks of rural region of Rajasthan (India). To understand the factors influencing the behavior of farmers towards green technologies, theory of planned behavior model has been applied. Data were collected using questionnaire/schedules, the sample size was chosen using convenience sampling, and were then examined further using SPSS and AMOS. In order to understand the elements of the TPB model and predict farmers’ behavioral intention towards adoption of solar water pumps, confirmatory factor analysis (CFA) and structural equation modelling (SEM) were applied in the study. The proposed research fills in the gap in the literature by performing an empirical study on farmer’s adoption behavior and offering insight about variables influencing farmers purchase intention and behavior of farmers towards solar water pump. Results from the study will be more useful to the policy makers to design effective strategies in order to achieve energy sufficiency without adversely affecting the environment.
Keywords: carbon emission, agriculture, irrigation, solar water pump, TPB model, sustainable development.
Charting the Course: Total Factor Productivity Trends in Croatia Post-pre-bankruptcy Act
Authors: Šergo Zdravko , Gržinić Jasmina , Sučić Červa Mirela
Published: December 2023

The synthetic control method (SCM) is a valuable tool for unbiased pre-bankruptcy reform analysis in economic policy evaluations. This study utilizes SCM to assess the impact of the Financial Operations and Pre-Bankruptcy Settlement Act (AFOPBS) on Croatia's total factor productivity (TFP). Control units and weights were meticulously chosen to construct a synthetic control for Croatia, creating a counterfactual scenario for the reform's absence. The policy's impact was quantified by comparing TFP growth post-policy between Croatia and its synthetic control. Placebo tests confirmed the results' significance, and further validation was achieved through panel difference-in-differences analysis (PDID). Our findings show that the pre-bankruptcy reform in late 2012 effectively reduced the gap between Croatia and its synthetic control throughout the post-treatment years. However, it had two short-term adverse impacts and a subsequent recovery-like phase. These effects were statistically significant and confirmed by cross-validation. In conclusion, Croatia's pre-bankruptcy reform significantly influenced TFP volatility, highlighting SCM's effectiveness in evaluating economic policies, especially those crucial for economic growth
Dravsko polje – rurbana pokrajina
Authors: Drozg Vladimir
Published: December 2023

Zaradi urbanizacije se agrarnost Dravskega polja vse bolj izgublja, v pokrajini je vse več urbanih elementov, zato termin rurbana pokrajina. Rurbanost Dravskega polja določajo objekti regionalnega pomena, nastali v obdobju industrializacije, kot je Kidričevo, letališče Edvarda Rusjana, kanal za HE Zlatoličje, infrastrukturni objekti ter območja melioriranih kmetijskih zemljišč. Zaradi intenzivne stanovanjske gradnje se je ruralna podoba naselij skoraj izgubila, prevladujejo urbani tipi stanovanjske hiše in urbani tloris naselij, spremenjena so središča ter značilnosti prometnic. V gospodarski strukturi neagrarne dejavnosti povsem prevladujejo nad agrarnimi, samo obseg kmetijskih zemljišč še govori o agrarni dejavnosti. Znak urbanosti so še številne povezave javnega prometa z bližnjimi urbanimi središči. Na območju je tudi vse več dejavnosti, značilnih za urbana območja: odlagališča odpadkov, objekti za pridobivanje energije, rekreacijska območja regionalnega značaja. Rurbanost ni na celotnem območju enaka, bolj izrazita je v bližini treh regionalnih središč.
Prihodnost Pragerskih ribnikov: pogled domačinov
Authors: Vovk Ana
Published: December 2023

Pragersko leži v jugovzhodnem delu Dravskega polja na peščeno-ilovnatih nanosih. V okviru projekta »Od kopánja do kópanja – glinokopne jame Pragerskega«, ki je potekal leta 2018 in 2019, je bil pripravljen vpogled v možnosti trajnostnega sobivanja s Pragerskimi ribniki, ki so posledica glinokopnih jam. V načrtovanje je bila vključena lokalna skupnost – domačini ter OŠ Antona Ingoliča. V terensko raziskovanje so bili vključeni tudi zainteresirani študenti. Pripravljen je bil elaborat nastanka in značilnosti glinokopnih jam. Pragerski ribniki so vodne površine, ki danes nimajo posebne vloge v življenju ljudi na Pragerskem. Dobro stanje voda mika domačine in investitorje, da bi pristopili k razvoju dejavnosti ob ribnikih. Izpeljava delavnic z domačini in intervjuja so razkrili, da si ljudje ne želijo masovnega turizma, ne podpirajo klasičnih oblik koriščenja glinokopnih jam z dejavnostmi, ki bi bremenile vodne površine. Njihova skupna odločitev je butični turizem, povezan z opazovanjem narave, tudi raziskovalni in učni turizem.
Nekatere lastnosti in aktivnosti starejših prebivalcev Dravskega polja
Authors: Hadner Maja , Ivajnšič Danijel , Konečnik Kotnik Eva
Published: December 2023

Delež ljudi, starejših od 65 let, narašča v razvitih državah, tudi v Sloveniji. Staranje prebivalstva vpliva na družbo kot celoto, kar se odraža tudi v prostoru. V poglavju so predstavljeni izsledki raziskave, s katero smo ugotavljali nekatere socialne lastnosti in aktivnosti starejših prebivalcev Dravskega polja, razlike med njimi in njihovo medsebojno pogojenost. Na razlike v izbranih socialnih lastnostih in aktivnostih med anketiranimi starejšimi posamezniki z Dravskega polja vplivajo dejavniki: višina dohodkov, stopnja izobrazbe in zdravstveno stanje. Spoznanja smo povezali z (družbeno)geografskimi značilnostmi regije. Opredelili smo povezavo z umeščenostjo naselij v prostor ter z razvojem in širitvijo naselij, gospodarskimi razmerami in njihovim vplivom na okolje. Poznavanje vzrokov heterogenosti v socialnih lastnostih ter v aktivnostih starostnikov lahko pripomore k razumevanju njihovega odnosa do prostora in delovanja v njem, s tem pa tudi na načrtovanje trajnostnih organizacijskih politik, vpeljavo ustreznih ukrepov in na kakovostno staranje v vse bolj starajoči se družbi Dravskega polja.
A Contribution to the History of Repentance Prayers in the Slavic South during the 15th Century
Authors: Tsibranska-Kostova Mariyana
Published: December 2023

The article explores and offers a diplomatic edition of A Very Useful Confession for Unction for Every Christian, for the Black and White Clergy. This is an autograph by Vladislav the Grammarian placed in the Trebnik of Monk David (1480s), manuscript 1/42 in the collection of the Rila Monastery. The analysis is based on the working hypothesis that after the conquest of Constantinople by the Ottoman Turks in 1453, the Ottoman invasion of the Balkans was perceived as a God’s punishment for the sins of the Orthodox Christians. This idea became strongly present in a number of texts. Penitential prayer patterns multiply in the literature. The Greek prototype of the text under study has not been identified yet, but features a close relation to the prayers with the so-called accumulation of sins. It is, in essence, a confession which is performed in connection with the sacrament of the eleosvet (anointing of the sick) before receiving communion and the anointing with holy oil. The textual unit was purposefully introduced into Monk David’s Trebnik and reflected topical textual additions to the basic composition of the Slavonic Trebnik.
Effectiveness Evaluation of Leaves Nerium oleander Extract on the Viability of Protoscolices: In vitro
Authors: Mares Mohammed M. , Murshed Mutee , Aljawdah Hossam M.A. , Hailan Waleed Ali , Al-Quraishy Saleh
Published: December 2023

Background: Echinococcus granulosus is a type of taeniid tapeworm, present in the small intestine of its primary hosts, including dogs and occasionally in other carnivores. The larval stage of E. granulosus causes cystic hydatidosis in humans and livestock. Although most hydatid cysts are found in the liver and lungs, the disease can occur anywhere in the body. Therefore, Hydatidosis remains a problem and causes significant economic losses in animals. Methods: A study was performed to evaluate the activity of the leaves Nerium oleander extract on the viability of protoscolices. We used three graduated concentrations of extract (10, 30 and 50 mg/ml). 2 ml of the protoscolices suspension (containing at least 2700 protoscolices) was placed in test tubes using a Pasteur pipette. Then, 2 ml of various concentrations of the Nerium oleander extract were added to each test tube and mixed gently, incubated at 37°C for 5, 10, 20 and 30 min. One control group was kept that contain normal saline. The viability of protoscolices was evaluated by eosin method where, protoscolices suspension was mixed with 0.1% eosin for 5 minutes. The dead protoscolices absorb eosin and becomes red, whereas the live protoscolices remains colorless. Before drawing the conclusion, each experiment was performed thrice. Result: The analysis of phytochemicals by FT-IR for alcoholic extracts of Nerium oleander extracts revealed the presence of 12 effective chemical ingredients. Nerium oleander extract showed the strongest scolicidal effect (85.6, 92.3%) after 20 and 30 min at a concentration of 50 mg/ml, respectively moderately (69.3%) after 30 min at 30 mg/ml and lowest (41.9%) after 30 min at 10 mg/ml. Microscopic examinations of dead protoscolices showed distortion of their morphology and degenerative effects. These effects were characterized by loss of hooks, or presence of free hooks and dissolution and rupture of the protoscolices wall. It can be concluded from this study that ethanol extract of Nerium oleander is effective against Protoscolies in vitro.
Therapeutic Potential of Cannabis Plant
Authors: Pote Siddhesh , Khurana Parul , Kaur Gaganjyot , Kokane Sonali
Published: December 2023

The aim of this review article is to outline the role of the plant Cannabis sativa in treating human ailments. Giant pharmaceuticalcompanies are marketing phytochemicals extracted from Cannabis plant and its derivatives to treat epilepsy and multiple sclerosis.The present review emphasizes cannabinoids – its derivatives and synthetic analogs – as an active pharmaceutical Ingredient to treatailments related to autoimmune human body responses. The endocannabinoid system CB1 and CB2 respond differently to variousphytochemicals such as cannabidiol, tetrahydrocannabinol and terpenes. They also interact with the endogenous ligands synthesized bythe human body. The role of nanotechnology in the design of a drug delivery system is discussed in this review. The advantages with theuse of Quantum dots are briefly outlined. Cannabis-based phytochemicals are known for psychotic and non-psychotic effects. We haveunderlined the immense potential of this plant in treating diseases. Cannabidiol (CBD) as one of the main non-psychotic phytochemicals,has established itself as an active pharmaceutical agent in some approved medicines worldwide. Cannabis-based phytochemicals can beused as targeted drug delivery vehicles. Future direction in this field could be a synthesis of derivatives of cannabidiol and its targeteddrug delivery to the cannabinoid receptors. In the oral route, the terpenes give the wholesome experience of consuming Cannabis.
Exploration of Mangroves Associated Microbes for Bioactive Metabolites
Authors: Paul Sushmita , Siddiqua Fatima , Tayung Kumananda
Published: December 2023

Mangroves are woody plants found growing at transition zones between land and sea in tropic and sub-tropical regions. They arehighly adapted morphologically and physiologically to survive in extreme environments. Mangroves are found worldwide in theirdistribution, with 110 species that belong to 20 different families. In India, mangrove forests are mostly found on the Andaman andNicobar Islands and the West and East Coast. Mangroves have enormous ecological, commercial and biological significance. They arealso regarded as hotspots for microbes because of their rich microbial diversity. Various types of microorganisms like bacteria, fungi,microalgae and macroalgae are abundant in mangrove ecosystems. More recently, fungal endophytes associated with mangroveshave added to their microbial diversity. Many mangrove plants are used as ethno-medicine in traditional health care. Mangroves arealso used as antimicrobial and antiviral agents. Fungal endophytes -colonizing medicinal plants are reported to produce importantbioactive metabolites. These endophytes are believed to produce same and more biologically active metabolites as compared to theirrespective hosts. Many fungal endophytes isolated from mangrove species have produced some important biological active metaboliteslike triterpenes, indole triterpenes, isocoumarin and marinamide. Therefore, the study of fungal endophytes associated with medicinalmangroves may give rise to important endophytic strains that might produce novel and new bioactive metabolites of pharmaceutical,industrial and agricultural importance. Due to the alarming rate of depletion of mangrove genetic resources across the world, it is highlyneeded to explore fungal endophytes associated with mangroves for the inventorisation of new metabolites.
Effect of the Static Magnetic Fields on the Circadian Rhythm in Arabidopsis thaliana
Authors: Dhiman Sunil K. , Agnihotri Ashish
Published: December 2023

The influence of geomagnetic field on various biological processes is certainly an interesting research field, and more work is beingperformed across the globe. However, the impact of varying magnetic flux density on plant circadian rhythms has not yet beencompletely investigated. Different researchers have mostly focused their attention on the molecular workings of circadian rhythms invarious plant systems and the circadian architecture of transcriptomes under varying conditions. The present investigation evaluatedthe influence of variable geomagnetic field on the expression of genes that are under the control of circadian rhythm, and checkedwhether the expression pattern of these genes with respect to time (circadian nature) under different magnetic flux density changesor not in Arabidopsis seedlings. This study examined the impact of varying magnetic flux densities on the mRNA expression levels ofsix genes in Arabidopsis thaliana during the final 33 hours of their total 120 hour growth period. A. thaliana seedlings were subjectedto four distinct magnetic flux densities (0, 25, 50, and 90 μT), and the abundance of transcripts for chlorophyll a/b binding protein 4,the large subunit of RuBisCO, rubisco activase, chalcone synthase, porphobilinogen synthase, and phytoene dehydrogenase genes wasexamined. While the present study’s findings lend credence to the idea that the aforementioned genes are differentially expressed inresponse to changes in magnetic flux density, it also proved that the circadian nature of these genes was largely unaffected, with theirexpression pattern remaining largely unaltered regardless of the strength of the magnetic field.
Physicochemical Characteristics of Sewage Water of Bilaspur City for Suitability for Irrigation Purposes
Authors: Tiwari Nidhi , Tiwari Uttara , Tiwari Ashish
Published: December 2023

The increasing demand for water due to population growth and globalization has led to sewage or wastewater being used to irrigatecrops. Irrigation with reused water has favorable effects on crops but also poses a threat to the ecosystem, soils, underground water,and human life. This research article presents an analysis of the physicochemical characteristics of sewage water in Bilaspur City todetermine its suitability for irrigation purposes. The study involved collecting and analyzing water samples from ten sampling sites inthe city. Results showed that the water had acceptable pH and salinity (Chloride). However, it has high turbidity, electrical conductivity,and biochemical oxygen demand, indicating poor quality of water. The levels of essential plant nutrients, such as nitrogen, phosphorus,and potassium, were found to be within the acceptable range for agricultural use. Statistical analysis was performed, and Karl Pearson’scoefficient was determined and analyzed for various physicochemical parameters. The study concludes that the sewage water in Bilaspurcity may be suitable for irrigation purposes after appropriate treatment and management. This research provides valuable insights forpolicymakers and municipal authorities in promoting sustainable wastewater management practices for agricultural purposes.
Sacred Groves as the Source of Local Medicinal Plants and Sites of Biodiversity Conservation in North 24 Parganas, West Bengal
Authors: Mahanty Dibyendu S. , Mazumder Shrabana
Published: December 2023

A Sacred Grove (SG) is any grove of trees, shrubs and even herbs of special religious importance to a particular culture. SGs are consideredas distinct patches of vegetation (ranging in size from a small cluster of a few trees to a large forest stand spanning several hundredacres) which are venerated in the name of local deities or ancestral spirits, promoting conservation. Conservation of biodiversity insacred groves is a consequence of the sacred physical space of the sacred grove which is communally shared as commons and used toobserve crucial social ceremonies in indigenous societies. While documenting the sacred groves in the district of North 24 Parganas ofWest Bengal through a detailed field survey, plants of local medicinal importance were identified in these patches in which the localpeople traditionally conserved the medicinal plants since time immemorial. An extensive field survey to potential district areas anddocumentation of major flora, including their correct identification and their related Traditional Knowledge (TK) in each SG was done.More than 120 local medicinal plants were found and traditional knowledge associated with these plants was documented whichincluded Adhatoda vasica, Abroma agustum, Andrographis paniculata, Bacopa monnieri, Centella asiatica, Cocculus hirsutus, Gloriosasuperba, Tinospora cordifolia to name very few. Out of these purified aqueous extract of Cocculus hirsutus has also been reported inCOVID-19 treatment in many research papers. Traditional knowledge associated with these plants found in the sacred groves is a hiddentreasure from where further research, learning and dissemination of potential information can ensue. These SGs are examples of in-situconservation traditionally by local people and gene pool for various medicinal plants.
Growth, Metal Accumulation Potential and Antioxidant Enzyme Responses of Ricinus communis L. Genotypes Exposed to Cement Industry Effluent
Authors: Bauddh Kuldeep , Ankit Ankit , Kumar Amit , Amir Mohammad
Published: December 2023

The current study was carried out to delineate the effect of cement industry effluent on the two screened varieties of R. communis(Castor) viz. MSC-55 and Western-6. A number of analyses such as growth parameters, photosynthetic pigment, metal accumulationand antioxidant enzyme were performed on both the varieties. With respect to T0 (100% tap water), an increase of 86.84, 90.97 and80.15% was noticed in the fresh weight (FW) of roots of MSC-55 variety at 30, 60 and 90 DAS, respectively, when irrigated with T2 (50%effluent+50% tap water). The results obtained significantly differed between T0 and T2 and T0 and T4 (at p ≤ 0.05). MSC-55 variety wasobserved to contain an increased amount of total chlorophyll and carotenoids up to T2 concentration which declined at higher effluentconcentration i.e., T4 (100% effluent). Increased concentration of Cement Industry Effluent (CIE) enhanced the generation of someantioxidant compounds like Guaiacol peroxidase (GPX) and Ascorbate peroxidase (APX) in both the varieties up to certain treatmentconcentrations viz. MSC-55 and Western-6. As the effluent concentration increased in both the varieties, the amount of malondialdehyde(MDA) in the leaves and roots also rose. With increasing effluent concentrations, Catalase (CAT) and Superoxide dismutase (SOD)also increased. MSC-55 variety of R. communis was observed to have a strong antioxidant defence system against CIE and could berecommended for cultivation during metal-contaminated industrial effluent condition.
An analysis of healthcare quality sustainability in public hospitals
Authors: Abou Elseoud Mohamed Sayed
Published: December 2023

The current study aims to determine, from the perspective of the patients, whether public hospitals can sustainably provide high-quality healthcare services according to the Kingdom of Bahrain 2030 vision. The study adopts quantitative and survey approaches by designing a questionnaire based on the five quality dimensions of the Service Quality (SERVQUAL) model. The survey was carried out between September 2021 and January 2022 when the Corona pandemic's restrictions were released. The 470 responses received were estimated and analyzed via correlations and multiple regression techniques. The main findings show that there is a significant influence of healthcare service quality on the overall patient, which ensures that public hospitals under study could achieve sustainably high-quality healthcare services in line with the Kingdom of Bahrain 2030 vision. The study recommends that hospital administration should continue its commitment to providing medical services to patients promptly. Employees must obtain incentives and training courses, which might significantly impact their job satisfaction and retention.
Keywords: Healthcare; public hospitals; SERVQUAL model; sustainability.
Fear of Covid 19, job stress, life satisfaction, job satisfaction, and burnout
Authors: Kavuran Esin , Camcib Gazi Baran
Published: December 2023

The Covid-19 pandemic has led to an unprecedented health crisis that has challenged both institutions and individuals around the world and healthcare workers have been the group most affected by the pandemic. Job satisfaction, life satisfaction, and burnout are interrelated concepts. Life satisfaction is directly affected by the mental and physical health of individuals. This review was written to determine nurses' fear of covid 19, work stress, life satisfaction, job satisfaction, and burnout. The review revealed that there are over 59 million healthcare workers in the world. For this reason, research in this field will guide health workers to prevent burnout, increase professional satisfaction and provide more effective psychological support in the field. Reasons such as heavy and long working hours, insufficient number of nurses, and inadequacy of emergency action plans during the pandemic have negatively affected the mental health of nurses and have caused them to experience burnout.
Keywords: Burnout; Covid-19; job; job satisfaction; life satisfaction; nurse; stress.
Cicatrização de feridas agudas tratadas com produto em pó à base de própolis verde
Authors: Faria Talita Faraj , Faria Roberta Faraj , Kamada Ivone , Barreto Lívia Cristina Lira de Sá
Published: December 2023

Objetivo: avaliar o potencial cicatrizante de um produto em pó à base de própolis verde em lesão aguda induzida em ratos. Método: trata-se de um estudo experimental realizado com 27 ratos da linhagem wistar divididos aleatoriamente em três grupos. As lesões foram induzidas cirurgicamente e tratadas a cada 48 horas com os produtos em teste (pó à base de própolis verde, Brava Ostomy Powder® e soro fisiológico). As lesões foram analisadas macroscópica e microscopicamente no 7º, 9º e 11º dia de pós-operatório. Resultados: a maioria das lesões tratadas com pó à base de própolis verde cicatrizou em 11 dias. O produto formulado para este estudo e o comercial mostraram resultados satisfatórios na retração das feridas, atividade anti-inflamatória, angiogênese, proliferação de fibroblastos e síntese de colágeno. Conclusão: o tratamento com o produto formulado à base de própolis verde mostrou grande potencial de cicatrização das lesões cutâneas.
Extraction of Flavonoid Compounds from Red Betel Leaves (Piper Crocatum) Using Ultrasound-Assisted Extraction (UAE) Method
Authors: Pramudiska Riavinola Viyoni , Amartya Audi Nur , Yolanda Ditta Kharisma , Mumtazah Zuhriah , Palupi Bekti
Published: December 2023

Red betel leaf is one of the medicinal plants known for its beneficial antioxidant content in maintaining overall health. One of the types of antioxidants found in red betel leaf is flavonoids. In this study, the extraction of red betel leaf was conducted using the Ultrasound-Assisted Extraction (UAE) method with the aim of analyzing the flavonoid content and antioxidant activity in the red betel leaf. A 90% ethanol solvent was used, and the extraction variables included the ratio of material to solvent, particle size, and extraction time, which were determined using Design Expert13 software. The flavonoid test was performed using a UV-Vis spectrophotometer at a wavelength of 431 nm. The analysis of antioxidant activity was conducted using DPPH (2,2-Diphenyl-1-picrylhydrazyl). The highest flavonoid content obtained was 263.676 mgQE/g under the optimum operating conditions with a particle size of 100 mesh, a material-to-solvent ratio of 0.06, and an extraction time of 25 minutes.
Uma análise crítica do papel da escola pública no combate às Fake News
Authors: Xavier Itamaragiba Chaves
Published: December 2023

O objetivo do artigo é analisar qual o papel da escola pública no combate às fake news. O referencial teórico-metodológico empregado está pautado no materialismo histórico e na pedagogia histórico-crítica. O termo fake news é compreendido como uma notícia falsa, dolosamente manipulada com o objetivo de enganar o receptor da desinformação. A escola pública deve propiciar que o aluno se aproprie da tecnologia que possibilitou a criação e divulgação das fake news, aprenda a navegar no ambiente virtual de forma ética e em oposição às notícias falsas que estimulam o discurso de ódio, o preconceito e que são contrárias aos interesses da classe trabalhadora. Além disso, compreender que uma parte significativa das fake news é elaborada por corporações poderosas, com recursos financeiros abundantes e por pessoas especializadas, que participam da disputa do poder econômico e político como intelectuais orgânicos das classes dominantes. Para finalizar, a escola pública deve cumprir a função de instrumentalizar os alunos/agentes sociais com as ferramentas necessárias para a luta de classe na sociedade atual.