bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of Forest Roads on Hydrological Processes
Authors: Kastridis Aristeidis
Published: November 2020

The current review summarizes the knowledge generated by the recently published studies of the last twenty years, in the field of forest road networks, concerning the impact of forest road construction on hydrological processes. The currently applied methodology techniques/practices are discussed, the findings are highlighted and effective mitigation measures to mitigate the impact of forest roads are proposed. Critical for the minimization of the impact of forest roads on overland flow is the significant decrease in road surface runoff and overland flow velocity. The decrease in runoff energy reduces the detachment of soil particles and transportation in streams. The disturbances of forest roads in logging areas should be limited to decrease soil erosion. Additionally, aiming to minimize sediment transportation into the streams, it is very important to reduce the connectivity between the forest roads (or skid trails) and streams. The positive role of vegetation and organic matter on the road prism, naturally/technically established riparian buffers along the streams, and the use of appropriate bioengineering designs for each area significantly decrease the runoff generation and sedimentation. From a construction point of view, the decrease in short and long-term forest road-related impact could be achieved by reducing the depth of excavations and the use of soil compaction limiting technology during forest works. The road network design should be more efficient, avoiding hydrologically active zero-order basins. Techniques that minimize the length and connectivity among skid trails, unpaved roads and streams are highly crucial. Broad-based dips, immediate revegetation and outsloping of the road base are considered good road construction practices. Research should be focused on the hydrologic behavior of forest road networks and on the impact at the watershed scale, the degree of connectivity, utilizing plenty of qualitative field data, especially during intense rainfall events, which has been proven to exacerbate the runoff and sediment generation and transportation into the stream networks.
An Interoperable UMLS Terminology Service Using FHIR
Authors: Saripalle Rishi , Sookhak Mehdi , Haghparast Mahboobeh
Published: November 2020

The Unified Medical Language System (UMLS) is an internationally recognized medical vocabulary that enables semantic interoperability across various biomedical terminologies. To use its knowledge, the users must understand its complex knowledge structure, a structure that is not interoperable or is not compliant with any known biomedical and healthcare standard. Further, the users also need to have good technical skills to understand its inner working and interact with UMLS in general. These barriers might cause UMLS usage concerns among inter-disciplinary users in biomedical and healthcare informatics. Currently, there exists no terminology service that normalizes UMLS’s complex knowledge structure to a widely accepted interoperable healthcare standard and allows easy access to its knowledge, thus hiding its workings. The objective of this research is to design and implement a light-weight terminology service that allows easy access to UMLS knowledge structured using the fast health interoperability resources (FHIR) standard, a widely accepted interoperability healthcare standard. The developed terminology service, named UMLS FHIR, leverages FHIR resources and features, and can easily be integrated into any application to consume UMLS knowledge in the FHIR format without the need to understand UMLS’s native knowledge structure and its internal working.
Towards the Development of a Probabilistic Approach to Informal Settlement Fire Spread Using Ignition Modelling and Spatial Metrics
Authors: Cicione Antonio , Gibson Lesley , Wade Colleen , Spearpoint Michael , Walls Richard , Rush David
Published: November 2020

Large conflagrations of informal settlements occur regularly, leaving thousands of people homeless daily and taking tens of thousands of lives annually. Over the past few years, a large amount of data has been collected from a number of full-scale informal settlement fire experiments. This paper uses that data with a semi-probabilistic fire model previously proposed by the authors, to illustrate the potential applications of the fire spread method proposed. The current model is benchmarked against a 20-dwelling full-scale informal settlement fire experiment, and the effects of the (a) ignition criteria, (b) wind direction, and (c) wind speeds on the predicted fire spread rates are investigated through the use of a parametric study. Colour maps of the fire spread rates and patterns are then used to visually interpret the effects of different types of fire scenarios and fire breaks. Finally, the fire spread capability within B-RISK is used to derive a linear equation for the potential fire spread rate as a function of the settlement spatial metrics (e.g., density and distance to nearest neighbour). To further illustrate the potential application of this work, the fire spread rate equation is then applied across the whole of Cape Town, South Africa, to show the 10 informal settlement areas most at “risk” of large conflagrations.
Arsenic in Soils Affected by Mining: Microscopic Studies vs. Sequential Chemical Extraction
Authors: Álvarez-Quintana Jessica , Álvarez Rodrigo , Ordóñez Almudena
Published: November 2020

Soil samples from three inactive mines, corresponding to different Arsenic-bearing mineralization types, were collected and studied. The aim was to determine the influence of mine wastes mineralogy/geochemistry and texture in As mobility and to compare results from sequential chemical extraction and microscopic techniques (optical and electron) at a grain scale. Arsenic in soils is found mainly associated to the residual fraction, indicating that mechanical As dispersion is mainly responsible for As soil pollution. The use of objective microscopic techniques (i.e., Scanning Electron Microscopy-Energy Dispersive Spectroscopy -SEM-EDS-, High Resolution Transmission Electron Microscopy -HR-TEM) has pointed out that the selected sequential extraction method overestimates the role of Mn amorphous oxy-hydroxides and organic matter in As retention while underestimating the mechanism of As adsorption onto clay particle surfaces.
Evaluation of the Combination of Muscle Energy Technique and Trigger Point Therapy in Asymptomatic Individuals with a Latent Trigger Point
Authors: Wendt Michał , Waszak Małgorzata
Published: November 2020

(1) Background: The aim of the study was to determine the effect of the combination therapy of Muscle Energy Technique (MET) and Trigger Point Therapy (TPT) on the angular values of the range of movements of the cervical spine and on the pressure pain threshold (PPT) of the trapezius muscle in asymptomatic individuals. METHODS: The study involved 60 right-handed, asymptomatic students with a latent trigger point in the upper trapezius muscle. All qualified volunteers practiced amateur symmetrical sports. The study used a tensometric electrogoniometer (cervical spine movement values) and an algometer (pressure pain threshold (PPT) of upper trapezius). Randomly (sampling frame), volunteers were assigned to three different research groups (MET + TPT, MET and TPT). All participants received only one therapeutic intervention. Measurements were taken in three time-intervals (pre, post and follow-up the next day after therapy). (2) Results: One-time combined therapy (MET + TPT) significantly increases the range of motion occurring in all planes of the cervical spine. One-time treatments of single MET and single TPT therapy selectively affect the mobility of the cervical spine. The value of the PPT significantly increased immediately after all therapies, but only on the right trapezius muscle, while on the left side only after the therapy combining MET with TPT. (3) Conclusion: The MET + TPT method proved to be the most effective, as it caused changes in all examined goniometric and subjective parameters.
Impact of a Comprehensive Anti-Smoking Program at a Regional University Hospital and Predictive Variables of Being a Smoker among Hospital Workers
Authors: Ranchal-Sánchez Antonio , Romero-Rodríguez Esperanza , Jurado-Castro Jose Manuel , Ruiz-Gandara África , Vaquero-Abellán Manuel
Published: November 2020

The objective of this study was to evaluate the impact of a comprehensive anti-smoking health program conducted over twelve years at a regional university hospital in southern Spain. Prevalence of tobacco was compared retrospectively using data collected during occupational health assessments (n = 4291). Bivariate and logistic regression analyses were carried out to evaluate tobacco consumption differences according to age, sex, professional category, and workplace building. The results show a reduction in the active smoking rate among hospital staff evaluated (from 22.8% to 19.8%) with significant differences between non-health and health workers. Accumulated smoking consumption fell to 13.45 ± 14.60 packs/year with men presenting a higher consumption (p < 0.001). The predictive variables of tobacco use were sex (greater consumption among men, p = 0.021), number of cigarettes (greater consumption among professionals who smoked less than 1 pack/day, p < 0.001), and time smoking (greater use among professionals with more than 10 years smoking, p < 0.001). There was a higher rate of staff smokers at the hospital building with a majority of mental health inpatients. This study provides a practical example of making the optimum use of digital medical records in the evaluation of a comprehensive anti-smoking health program.
Family Support, Multidimensional Health, and Living Satisfaction among the Elderly: A Case from Shaanxi Province, China
Authors: Wang Lijian , Yang Liu , Di Xiaodong , Dai Xiuliang
Published: November 2020

The current study investigated the association between three types of family support and living satisfaction of elderly individuals in China, and paid particular attention to the possible mediating role of the elderly population’s multidimensional health. A cross-sectional survey was conducted in 2019, and 938 elderly people from seven counties (districts) of China’s Shaanxi province were enrolled. Multivariable linear regression and mediation effect analysis were employed to examine the integrated relationships among these variables. The results showed that emotional support and decisional support from families were positively related to the living satisfaction of elderly individuals (β = 0.101, p = 0.000; β = 0.263, p = 0.000), while the relationship between daily living support and living satisfaction was not significant (β = 0.017, p > 0.05). The mediation examination further demonstrated that both mental state and social integration mediated the association between emotional support and living satisfaction, as well as the association between decisional support and living satisfaction, but a mediating effect of physical health was not observed. These results indicate the pathways in the relationships of different types of family support to living satisfaction via mental state and social integration, having significant implications for enhancing the living satisfaction the elderly.
Antioxidants and Exercise Performance: With a Focus on Vitamin E and C Supplementation
Authors: Higgins Madalyn , Izadi Azimeh , Kaviani Mojtaba
Published: November 2020

Antioxidant supplementation, including vitamin E and C supplementation, has recently received recognition among athletes as a possible method for enhancing athletic performance. Increased oxidative stress during exercise results in the production of free radicals, which leads to muscle damage, fatigue, and impaired performance. Despite their negative effects on performance, free radicals may act as signaling molecules enhancing protection against greater physical stress. Current evidence suggests that antioxidant supplementation may impair these adaptations. Apart from athletes training at altitude and those looking for an immediate, short-term performance enhancement, supplementation with vitamin E does not appear to be beneficial. Moreover, the effectiveness of vitamin E and C alone and/or combined on muscle mass and strength have been inconsistent. Given that antioxidant supplements (e.g., vitamin E and C) tend to block anabolic signaling pathways, and thus, impair adaptations to resistance training, special caution should be taken with these supplements. It is recommended that athletes consume a diet rich in fruits and vegetables, which provides vitamins, minerals phytochemicals, and other bioactive compounds to meet the recommended intakes of vitamin E and C.
AI and Blockchain Integrated Billing Architecture for Charging the Roaming Electric Vehicles
Authors: Yaqub Raziq , Ahmad Sadiq , Ali Hassan , Asar Azzam ul
Published: November 2020

Due to the proliferation of extended travel range electric vehicles (EVs), these will travel through different networks that might be served by different utility companies. Therefore, we propose an architecture capable of offering a charging service to roaming vehicles. Furthermore, although the energy internet supports both the flow of energy and information, it does not support seamless EV roaming service, because it is based on a centralized architecture. The blockchain technology that is based on a decentralized system has the potential to support a secure billing platform for charging the EVs roaming through different electrical jurisdictions. Furthermore, the integration of artificial intelligence (AI) ensures that the participating players get a fair portion of the revenue. Thus, the objective of this paper is to develop an AI and blockchain integrated billing architecture that would offer a charging service to the “roaming” EVs and present a fair and unified billing solution.
Evolution of Developmental GATA Factors in Nematodes
Authors: Eurmsirilerd Ethan , Maduro Morris F.
Published: November 2020

GATA transcription factors are found in animals, plants, and fungi. In animals, they have important developmental roles in controlling specification of cell identities and executing tissue-specific differentiation. The Phylum Nematoda is a diverse group of vermiform animals that inhabit ecological niches all over the world. Both free-living and parasitic species are known, including those that cause human infectious disease. To date, GATA factors in nematodes have been studied almost exclusively in the model system C. elegans and its close relatives. In this study, we use newly available sequences to identify GATA factors across the nematode phylum. We find that most species have fewer than six GATA factors, but some species have 10 or more. Comparisons of gene and protein structure suggest that there were at most two GATA factors at the base of the phylum, which expanded by duplication and modification to result in a core set of four factors. The high degree of structural similarity with the corresponding orthologues in C. elegans suggests that the nematode GATA factors share similar functions in development.
Nutritional Therapy for Athletes with Diabetes
Authors: Cannata Francesca , Vadalà Gianluca , Ambrosio Luca , Papalia Rocco , Napoli Nicola
Published: November 2020

Diabetes is a worldwide disease also affecting the sports field. The two main forms of diabetes, namely type 1 diabetes (T1D) and type 2 diabetes (T2D), differ in both their pathological and pharmacological characteristics and thus require a distinct nutritional treatment. Diet plays an important role in the management of athletes with diabetes and is crucial to achieving their best performance. This review aims to investigate the objectives of nutritional therapy before, during and after training, in order to improve the best composition of macronutrients during meals. In this review, we provide a brief overview of recent studies about nutritional approaches to people with diabetes for performance optimization and for the control of diabetes-related complications. Thereafter, we discuss the differences between macronutrients and dietary intake before, during and after training. It can be concluded that each sport has particular characteristics in terms of endurance and power, hence demanding a specific energy expenditure and consequent nutritional adjustments. Therefore, the management of athletes with diabetes must be personalized and supported by medical professionals, including a diabetologist, physiologist and a nutritionist.
Overreaction in the REITs Market: New Evidence from Quantile Autoregression Approach
Authors: Ngene Geoffrey M. , Manohar Catherine Anitha , Julio Ivan F.
Published: November 2020

Real estate investment trusts (REITs) provide portfolio diversification and tax benefits, a stable stream of income, and inflation hedging to investors. This study employs a quantile autoregression model to investigate the dependence structures of REITs’ returns across quantiles and return frequencies. This approach permits investigation of the marginal and aggregate effects of the sign and size of returns, business cycles, volatility, and REIT eras on the dependence structure of daily, weekly, and monthly REIT returns. The study documents asymmetric and misaligned dependence patterns. A bad market state is characterized by either positive or weakly negative dependence, while a good market state is generally marked by negative dependence on past returns. The results are consistent with under-reaction to good news in a bad state and overreaction to bad news in a good state. Past negative returns increase and decrease the predictability of REIT returns at lower and upper quantiles, respectively. Extreme positive returns in the lower (upper) quantiles dampen (amplify) autocorrelation of daily, weekly, and monthly REIT returns. The previous day’s REIT returns dampen autoregression more during recession periods than during non-recession periods. The marginal impact of the high volatility of daily returns supports a positive feedback trading strategy. The marginal impact of the Vintage REIT era on monthly return autocorrelation is higher than the New REIT era, suggesting that increased participation of retail and institutional investors improves market efficiency by reducing REITs’ returns predictability. Overall, the evidence supports the time-varying efficiency of the REITs markets and adaptive market hypothesis. The predictability of REIT returns is driven by the state of the market, sign, size, volatility, and frequency of returns. The results have implications for trading strategies, policies for the real estate securitization process, and investment decisions.
The Effect of Forms’ Ratio of Conditioning on Word-Final /s/ Voicing in Mexican Spanish
Authors: Brown Earl Kjar
Published: November 2020

There is mounting evidence that words that occur proportionately more often in contexts that condition a phonetically-motivated sound change end up changing more rapidly than other words. Support has been found in at least modern-day Spanish, Medieval Spanish, bilingual English-Spanish, and modern-day English. This study tests whether there is support for this idea with regards to the variable voicing of word-final /s/ in Spanish. An analysis of 1431 tokens of word-final /s/ spoken by 15 female speakers of Mexican Spanish living in Salinas, California, USA is performed. The response variable is the percentage of the /s/ segment that is voiced, and the effect of a handful of predictor variables shown in the literature to condition /s/ voicing is investigated. The variable of interest is forms’ ratio of conditioning (FRC), or the proportion of times with which word types occur in the context that conditions voicing of word-final /s/. The results of a series of 40 beta regression models indicate that FRC significantly conditions the percentage of voicing of word-final /s/ in these data. Also, the effect of manipulating two aspects of FRC operationalization is analyzed. This study adds to the growing body of literature documenting the importance of cumulative contextual information in the mental representation of words.
Utility Indifference Valuation for Defaultable Corporate Bond with Credit Rating Migration
Authors: Huang Zhehao , Li Zhenghui , Wang Zhenzhen
Published: November 2020

Credit risk modeling by debt pricing has been a popular theme in both academia and practice since the subprime crisis. In this paper, we devote our study to the indifferent price of a corporate bond with credit risk involving both default risk and credit rating migration risk in an incomplete market. The firm’s stock and a financial index on the market as tradable assets are introduced to hedge the credit risk, and the bond price is determined by the indifference of investors’ utilities with and without holding the bond. The models are established under the structural framework and result in Hamilton–Jacobi–Bellman (HJB) systems regarding utilities subject to default boundary and multiple migration boundaries. According to dynamic programming theory, closed-form solutions for pricing formulas are derived by implementing an inverted iteration program to overcome the joint effect of default and multiple credit rating migration. Therefore, with the derived explicit pricing formulas for the corporate bond, the models can be easily applied in practice, and investors can generate their strategies of hedging the credit risk by easily analyzing the impacts of the parameters on the bond price.
Mathematical Modeling Projects Oriented towards Social Impact as Generators of Learning Opportunities: A Case Study
Authors: Albarracín Lluís , Gorgorió Núria
Published: November 2020

This paper presents a case study carried out at an elementary school that led to a characterization of mathematical modeling projects aimed at generating social impact. It shows their potential as generators of mathematical learning opportunities. In the school project, upper-grade students (sixth grade, 11-year-olds) studied the way in which the rest of the students at the institution traveled from their homes to school. Its purpose was to identify risk points from the standpoint of road safety and to develop a set of recommendations so that all the children could walk safely to school. In our study, we identified, on the one hand, the mathematical learning opportunities that emerged during the development of the project and, on the other, the mathematical models created by the students. We discuss the impact of the project on the different groups in the school community (other students, parents, and teachers). We conclude with a characterization of the mathematical modeling projects oriented towards social impact and affirm that they can be generators of mathematical learning opportunities.
A Generalized Viscosity Inertial Projection and Contraction Method for Pseudomonotone Variational Inequality and Fixed Point Problems
Authors: Jolaoso Lateef Olakunle , Aphane Maggie
Published: November 2020

We introduce a new projection and contraction method with inertial and self-adaptive techniques for solving variational inequalities and split common fixed point problems in real Hilbert spaces. The stepsize of the algorithm is selected via a self-adaptive method and does not require prior estimate of norm of the bounded linear operator. More so, the cost operator of the variational inequalities does not necessarily needs to satisfies Lipschitz condition. We prove a strong convergence result under some mild conditions and provide an application of our result to split common null point problems. Some numerical experiments are reported to illustrate the performance of the algorithm and compare with some existing methods.
Adaptive Particle Swarm Optimization of PID Gain Tuning for Lower-Limb Human Exoskeleton in Virtual Environment
Authors: Soleimani Amiri Mohammad , Ramli Rizauddin , Ibrahim Mohd Faisal , Abd Wahab Dzuraidah , Aliman Norazam
Published: November 2020

Tuning of a proportional-integral-derivative (PID) controller for a complex multi-joint structure, such as an exoskeleton, using conventional methods is difficult and imprecise. In this paper, an optimal PID tuning method for a 3-dimensional model of a lower-limb human exoskeleton in gait training condition is presented. The dynamic equation of the human-exoskeleton is determined using a Lagrangian approach, and its transfer function is established in a closed-loop control system. PID controller gains, initialized by the Ziegler–Nichols (Z-N) method, are used as the input to an adaptive particle swarm optimization (APSO) algorithm for minimizing the multi-joint trajectory error. The optimized controller is tested in the Gazebo virtual environment and compared with the Z-N and conventional optimization methods. The numerical analysis shows that the PID controller tuned by a combination of Z-N and APSO improves the performance of a lower-limb human exoskeleton in gait training.
Microbial Diversity and Phage–Host Interactions in the Georgian Coastal Area of the Black Sea Revealed by Whole Genome Metagenomic Sequencing
Authors: Jaiani Ekaterine , Kusradze Ia , Kokashvili Tamar , Geliashvili Natia , Janelidze Nino , Kotorashvili Adam , Kotaria Nato , Guchmanidze Archil , Tediashvili Marina , Prangishvili David
Published: November 2020

Viruses have the greatest abundance and highest genetic diversity in marine ecosystems. The interactions between viruses and their hosts is one of the hot spots of marine ecology. Besides their important role in various ecosystems, viruses, especially bacteriophages and their gene pool, are of enormous interest for the development of new gene products with high innovation value. Various studies have been conducted in diverse ecosystems to understand microbial diversity and phage–host interactions; however, the Black Sea, especially the Eastern coastal area, remains among the least studied ecosystems in this regard. This study was aimed at to fill this gap by analyzing microbial diversity and bacteriophage–host interactions in the waters of Eastern Black Sea using a metagenomic approach. To this end, prokaryotic and viral metagenomic DNA from two sampling sites, Poti and Gonio, were sequenced on the Illumina Miseq platform and taxonomic and functional profiles of the metagenomes were obtained using various bioinformatics tools. Our metagenomics analyses allowed us to identify the microbial communities, with Proteobacteria, Cyanobacteria, Actinibacteria, and Firmicutes found to be the most dominant bacterial phyla and Synechococcus and Candidatus Pelagibacter phages found to be the most dominant viral groups in the Black Sea. As minor groups, putative phages specific to human pathogens were identified in the metagenomes. We also characterized interactions between the phages and prokaryotic communities by determining clustered regularly interspaced short palindromic repeats (CRISPR), prophage-like sequences, and integrase/excisionase sequences in the metagenomes, along with identification of putative horizontally transferred genes in the viral contigs. In addition, in the viral contig sequences related to peptidoglycan lytic activity were identified as well. This is the first study on phage and prokaryote diversity and their interactions in the Eastern coastal area of the Black Sea using a metagenomic approach.
Invasive Seaweeds in the Iberian Peninsula: A Contribution for Food Supply
Authors: Pacheco Diana , Araújo Glacio Souza , Cotas João , Gaspar Rui , Neto João M. , Pereira Leonel
Published: November 2020

The introduction of exotic organisms in marine ecosystems can lead to economic and ecological losses. Globally, seaweeds represent a significant part of these non-indigenous species (NIS), with 407 introduced algal species. Furthermore, the presence of NIS seaweeds has been reported as a major concern worldwide since the patterns of their potential invasion mechanisms and vectors are not yet fully understood. Currently, in the Iberian Peninsula, around 50 NIS seaweeds have been recorded. Some of these are also considered invasive due to their overgrowth characteristic and competition with other species. However, invasive seaweeds are suitable for industrial applications due to their high feedstock. Hence, seaweeds’ historical use in daily food diet, allied to research findings, showed that macroalgae are a source of nutrients and bioactive compounds with nutraceutical properties. The main goal of this review is to evaluate the records of NIS seaweeds in the Iberian Peninsula and critically analyze the potential of invasive seaweeds application in the food industry.
Estimation of Proinflammatory Factors in the Saliva of Adult Patients with Cystic Fibrosis and Dental Caries
Authors: Hildebrandt Tomasz , Zawilska Anna , Trzcionka Agata , Tanasiewicz Marta , Mazurek Henryk , Świętochowska Elżbieta
Published: November 2020

Introduction: The available literature lacks data regarding the levels of resistin, lysozyme, lactoferrin, α-amylase activity, pH, and saliva buffer capacity, as well as oral health and hygiene in the group of adult patients with cystic fibrosis (CF). The aim of the research was to assess the selected saliva parameters in patients diagnosed with cystic fibrosis. Materials and methods: Examined group was composed of 40 patients diagnosed with CF, while the control group of 40 healthy individuals. Both groups underwent the same scheme of the assessment (DMT index, salivary pH, buffer capacity, analysis of total sialic acid, total protein estimation, lysozyme levels estimation, lactofferin levels measurement, α-amylase activity, estimation of the levels of resistin and TNF-α). Results: In the examined group, there were higher values of decayed teeth as well as values of sialic acid, total protein, lactoferrin, α-amylase, and TNF-α. However, mean lysozyme, and resistin levels, as well as pH and buffer capacity of the saliva, were lower. Conclusions: New diagnostic methods, including the evaluation of selected salivary biochemical parameters, may indicate the existence of factors predisposing to severe tooth decay in the study group. Appropriate preventive treatment to combat dental caries in adult patients with CF will significantly improve their comfort and life expectancy.
Pre-Discharge Predictors of 1-Year Rehospitalization in Adolescents and Young Adults with Severe Mental Disorders: A Retrospective Cohort Study
Authors: Bartoli Francesco , Cavaleri Daniele , Moretti Federico , Bachi Bianca , Calabrese Angela , Callovini Tommaso , Cioni Riccardo M. , Riboldi Ilaria , Nacinovich Renata , Crocamo Cristina , Carrà Giuseppe
Published: November 2020

Background and objectives: Readmissions of youths hospitalized for a severe mental disorder are common events and bear a remarkable human, social, and economic burden. The current study aimed at evaluating predictors of 1-year rehospitalization in a sample of adolescents and young adults with severe mental disorders. Materials and Methods: Data for ≤25-year-old inpatients with a severe mental disorder and consecutively admitted between 1 January 2016 and 30 June 2019 were collected. Subjects were retrospectively assessed over a follow-up period of one year after the index discharge to track readmissions—i.e., the primary outcome variable. Standard descriptive statistics were used. The association between variables and 1-year rehospitalization was estimated using the univariate Cox proportional hazards regression model. We then carried out a multivariable Cox regression model, also estimating the covariate-adjusted survivor function. Hazard ratios (HRs) with related 95% confidence intervals (95% CIs) were provided. Results: The final sample included 125 individuals. The multivariable Cox regression model estimated that co-occurring substance use disorders (HR = 2.14; 95% CI: 1.08 to 4.26; p = 0.029) and being admitted for a suicide attempt (HR = 2.49; 95% CI: 1.13 to 5.49; p = 0.024) were both significant predictors of 1-year rehospitalization. Conclusions: Our study showed that comorbid substance use disorders and being admitted for a suicide attempt were predictors of early readmission in youths with severe mental disorders. Although their generalizability is limited, our findings could contribute to improve the quality of young patients’ mental health care by identifying vulnerable subjects who may benefit from tailored interventions to prevent rehospitalizations.
Pathophysiological Perspective of Osteoarthritis
Authors: Yunus Mohd Heikal Mohd , Nordin Abid , Kamal Haziq
Published: November 2020

Osteoarthritis (OA) is the most well-known degenerative disease among the geriatric and is a main cause of significant disability in daily living. It has a multifactorial etiology and is characterized by pathological changes in the knee joint structure including cartilage erosion, synovial inflammation, and subchondral sclerosis with osteophyte formation. To date, no efficient treatment is capable of altering the pathological progression of OA, and current therapy is broadly divided into pharmacological and nonpharmacological measures prior to surgical intervention. In this review, the significant risk factors and mediators, such as cytokines, proteolytic enzymes, and nitric oxide, that trigger the loss of the normal homeostasis and structural changes in the articular cartilage during the progression of OA are described. As the understanding of the mechanisms underlying OA improves, treatments are being developed that target specific mediators thought to promote the cartilage destruction that results from imbalanced catabolic and anabolic activity in the joint.
Carbohydrate Antigen 50: Values for Diagnosis and Prognostic Prediction of Intrahepatic Cholangiocarcinoma
Authors: Luang Sukanya , Teeravirote Karuntarat , Saentaweesuk Waraporn , Ma-In Prasertsri , Silsirivanit Atit
Published: November 2020

Background and objectives: Cancer-associated carbohydrate antigen 50 (CA50) is a marker for detection of gastrointestinal cancers, especially of pancreatic and colon cancer. In this study, the power of CA50 as a diagnostic and prognostic marker was evaluated in intrahepatic cholangiocarcinoma (iCCA). Materials and Methods: Serum CA50 levels of iCCA patients and non-cholangiocarcinoma controls (non-CCA, including healthy persons and patients with benign biliary diseases and other gastrointestinal cancers) were measured using MAGLUMI®800 CLIA analyzer. Diagnostic and prognostic values of serum CA50 levels were evaluated. Results: CA50 levels in the sera of iCCA patients were significantly higher than those of non-CCA controls (p < 0.001, Mann–Whitney U test). Using cut-off value of 25 U/mL, CA50 provided 65.9% sensitivity, 87.3% specificity, and 80.1% accuracy for diagnosis of iCCA. Serum CA50 levels were increased and associated with the severity of bile duct pathology. In addition, a higher level of CA50 was associated with poor clinical outcome and shorter survival in iCCA patients. Multivariate survival analysis by Cox regression model revealed the potential of CA50 as an independent poor prognostic indicator for iCCA, regardless of the age, sex, histological types, or tumor stages. Conclusions: CA50 can be a diagnostic and poor prognostic marker candidate for iCCA.
Movable Die and Loading Path Design in Tube Hydroforming of Irregular Bellows
Authors: Hwang Yeong-Maw , Tsai Yau-Jiun
Published: November 2020

Manufacturing of irregular bellows with small corner radii and sharp angles is a challenge in tube hydroforming processes. Design of movable dies with an appropriate loading path is an alternative solution to obtain products with required geometrical and dimensional specifications. In this paper, a tube hydroforming process using a novel movable die design is developed to decrease the internal pressure and the maximal thinning ratio in the formed product. Two kinds of feeding types are proposed to make the maximal thinning ratio in the formed bellows as small as possible. A finite element simulation software “DEFORM 3D” is used to analyze the plastic deformation of the tube within the die cavity using the proposed movable die design. Forming windows for sound products using different feeding types are also investigated. Finally, tube hydroforming experiments of irregular bellows are conducted and experimental thickness distributions of the products are compared with the simulation results to validate the analytical modeling with the proposed movable die concept.
Pulse Knowledge, Attitudes, Practices, and Cooking Experience of Midwestern US University Students
Authors: Winham Donna M. , Davitt Elizabeth D. , Heer Michelle M. , Shelley Mack C.
Published: November 2020

Many American college students fail to meet dietary guideline recommendations for fruits, vegetables, and fiber. Pulses are a subgroup of legumes, harvested solely for dry grain seeds within a pod. Commonly consumed pulses include dry beans, dry peas, lentils, and chickpeas. Pulses are high in shortfall nutrients and could fill some nutritional gaps of college students. However, little is known about pulse intakes among young adults. The study aims were: (1) to identify knowledge, attitudes, and practices regarding pulse consumption; and (2) to describe experiences of preparing dry pulses among college students. A convenience sample of 1433 students aged 18–30 enrolled at a Midwestern university in the United States completed an online survey in April 2020. Demographic and attitude variables were compared by the monthly count of pulse types eaten using chi-square, analysis of variance, and logistic regression modeling to predict pulse type intakes. Higher numbers of pulse types eaten was associated with being White, vegetarian/vegan, higher cooking self-efficacy, positive attitudes toward pulses, and greater daily intake of fruits, vegetables, and fiber. Knowledge and experience of cooking dry pulses was low, with canned pulses purchased more often. College students may not be consuming pulses due to unfamiliarity with them, low knowledge of nutrition benefits, and a general lack of cooking self-efficacy. Increased familiarization and promotion surrounding pulses may increase their consumption.
Metabolic Syndrome: Past, Present and Future
Authors: Lemieux Isabelle , Després Jean-Pierre
Published: November 2020

Most clinicians and health professionals have heard or read about metabolic syndrome [...]
Diet as a Modulator of Intestinal Microbiota in Rheumatoid Arthritis
Authors: Dourado Eduardo , Ferro Margarida , Sousa Guerreiro Catarina , Fonseca João Eurico
Published: November 2020

Rheumatoid arthritis (RA) is a chronic immune-driven inflammatory disease characterised by synovial inflammation, leading to progressive cartilage and bone destruction, impacting patients’ functional capacity and quality of life. Patients with RA have significant differences in gut microbiota composition when compared to controls. Intestinal dysbiosis influences the intestinal barrier strength, integrity and function, and diet is considered the main environmental factor impacting gut microbiota. Over the last few years, researchers have focused on the influence of single components of the diet in the modulation of intestinal microbiota in RA rather than whole dietary patterns. In this review, we focus on how the Mediterranean diet (MD), a whole dietary pattern, could possibly act as an adjuvant therapeutic approach, modulating intestinal microbiota and intestinal barrier function in order to improve RA-related outcomes. We also review the potential effects of particular components of the MD, such as n-3 polyunsaturated fatty acids (PUFAs), polyphenols and fibre.
Effect of a Mediterranean Diet-Based Nutritional Intervention on the Risk of Developing Gestational Diabetes Mellitus and Other Maternal-Fetal Adverse Events in Hispanic Women Residents in Spain
Authors: Melero Verónica , García de la Torre Nuria , Assaf-Balut Carla , Jiménez Inés , del Valle Laura , Durán Alejandra , Bordiú Elena , Valerio Johanna J. , Herraiz Miguel A , Izquierdo Nuria , Torrejón Maria José , Runkle Isabelle , Barabash Ana , Rubio Miguel A , Calle-Pascual Alfonso L
Published: November 2020

Gestational diabetes mellitus (GDM) is the most frequent morbidity found in pregnancy, and it increases the risk for several maternal-fetal complications. Hispanic women are considered at high risk. The St. Carlos GDM prevention study is a randomized controlled trial (RCT) conducted from 2016–2017. Normoglycemic women were randomized at 12–14 Gestation week (WG) to an intervention group (IG) receiving recommendations based on the MedDiet (supplemented with ExtraVirgin Olive Oil/pistachios), or to a control group (CG), recommended to limit fat intake. After RCT conclusion, IG recommendations were applied to a real-world group (RW) in routine clinical practice. The primary endpoint of the current study is an assessment of the GDM rate in Hispanic participants of the aforementioned studies: 132 RCT, 128 CT, 284 RW participants. The GDM rate was lower in IG: 19/128(14.8%), p = 0.021, and RW: 38/284(13.4%), p = 0.029) than in CG: 34/132(25.8%). Adjusted RR (95%CI) for GDM: 0.72 (0.50–0.97), p = 0.037 in IG and 0.77 (0.61–0.97), p = 0.008 in RW. Rates of urinary tract infections, emergency caesarean-sections and perineal trauma were also lower in IG and RW. Other adverse outcomes were lower in IG vs. CG. In conclusion, a MedDiet-based intervention reduces the rate of GDM and several adverse maternal-fetal outcomes in Hispanic women residing in Spain.
Innovations in Infant Feeding: Future Challenges and Opportunities in Obesity and Cardiometabolic Disease
Authors: Alvarez-Pitti Julio , de Blas Ana , Lurbe Empar
Published: November 2020

The field of nutrition in early life, as an effective tool to prevent and treat chronic diseases, has attracted a large amount of interest over recent years. The vital roles of food products and nutrients on the body’s molecular mechanisms have been demonstrated. The knowledge of the mechanisms and the possibility of controlling them via what we eat has opened up the field of precision nutrition, which aims to set dietary strategies in order to improve health with the greatest effectiveness. However, this objective is achieved only if the genetic profile of individuals and their living conditions are also considered. The relevance of this topic is strengthened considering the importance of nutrition during childhood and the impact on the development of obesity. In fact, the prevalence of global childhood obesity has increased substantially from 1990 and has now reached epidemic proportions. The current narrative review presents recent research on precision nutrition and its role on the prevention and treatment of obesity during pediatric years, a novel and promising area of research.
Oral Nutrition during and after Critical Illness: SPICES for Quality of Care!
Authors: Fadeur Marjorie , Preiser Jean-Charles , Verbrugge Anne-Marie , Misset Benoit , Rousseau Anne-Françoise
Published: November 2020

Malnutrition is associated to poor outcomes in critically ill patients. Oral nutrition is the route of feeding in less than half of the patients during the intensive care unit (ICU) stay and in the majority of ICU survivors. There are growing data indicating that insufficient and/or inadequate intakes in macronutrients and micronutrients are prevalent within these populations. The present narrative review focuses on barriers to food intakes and considers the different points that should be addressed in order to optimize oral intakes, both during and after ICU stay. They are gathered in the SPICES concept, which should help ICU teams improve the quality of nutrition care following 5 themes: swallowing disorders screening and management, patient global status overview, involvement of dieticians and nutritionists, clinical evaluation of nutritional intakes and outcomes, and finally, supplementation in macro-or micronutrients.
Vitamin D3 as Potential Treatment Adjuncts for COVID-19
Authors: Malaguarnera Lucia
Published: November 2020

Severe acute respiratory syndrome coronavirus type (SARS-CoV2, also known as COVID-19), which is the latest pandemic infectious disease, constitutes a serious risk to human health. SARS-CoV2 infection causes immune activation and systemic hyperinflammation which can lead to respiratory distress syndrome (ARDS). ARDS victims are characterized by a significant increase in IL-6 and IL-1. Macrophage activation, associated with the “cytokine storm”, promotes the dysregulation of the innate immunity. So far, without vaccines or specific therapy, all efforts to design drugs or clinical trials are worthwhile. Vitamin D and its receptor vitamin D receptor (VDR) exert a critical role in infections due to their remarkable impact on both innate and adaptive immune responses and on the suppression of the inflammatory process. The protective properties of vitamin D supplementation have been supported by numerous observational studies and by meta-analysis of clinical trials for prevention of viral acute respiratory infection. In this review, we compare the mechanisms of the host immune response to SARS-CoV2 infection and the immunomodulatory actions that vitamin D exerts in order to consider the preventive effect of vitamin D supplementation on SARS-CoV2 viral infection.
Choline Plus Working Memory Training Improves Prenatal Alcohol-Induced Deficits in Cognitive Flexibility and Functional Connectivity in Adulthood in Rats
Authors: Waddell Jaylyn , Hill Elizabeth , Tang Shiyu , Jiang Li , Xu Su , Mooney Sandra M.
Published: November 2020

Fetal alcohol spectrum disorder (FASD) is the leading known cause of intellectual disability, and may manifest as deficits in cognitive function, including working memory. Working memory capacity and accuracy increases during adolescence when neurons in the prefrontal cortex undergo refinement. Rats exposed to low doses of ethanol prenatally show deficits in working memory during adolescence, and in cognitive flexibility in young adulthood. The cholinergic system plays a crucial role in learning and memory processes. Here we report that the combination of choline and training on a working memory task during adolescence significantly improved cognitive flexibility (performance on an attentional set shifting task) in young adulthood: 92% of all females and 81% of control males formed an attentional set, but only 36% of ethanol-exposed males did. Resting state functional magnetic resonance imaging showed that functional connectivity among brain regions was different between the sexes, and was altered by prenatal ethanol exposure and by choline + training. Connectivity, particularly between prefrontal cortex and striatum, was also different in males that formed a set compared with those that did not. Together, these findings indicate that prenatal exposure to low doses of ethanol has persistent effects on brain functional connectivity and behavior, that these effects are sex-dependent, and that an adolescent intervention could mitigate some of the effects of prenatal ethanol exposure.
Examination of the Eating Behavior of the Hungarian Population Based on the TFEQ-R21 Model
Authors: Szakály Zoltán , Kovács Bence , Szakály Márk , T. Nagy-Pető Dorka , Gál Tímea , Soós Mihály
Published: November 2020

Several theories have emerged to study types of eating behavior leading to obesity, but most of the applied models are mainly related to food choice decisions and food consumer behavior. The purpose of this paper was to examine the eating attitudes of Hungarian consumers by applying the Three-Factor Eating Questionnaire (TFEQ-R21). The national representative questionnaire involved 1000 individuals in Hungary in 2019. Several multivariate statistical techniques were applied for the data analysis: exploratory and confirmatory factor analyses, multivariate data reduction techniques, and cluster analysis. This study successfully managed to distinguish the following factors: emotional eating, uncontrolled eating, and cognitive restraint. By using the factors, five clusters were identified: Uncontrolled Emotional Eaters; Overweight, Uncontrolled Eaters; Controlled, Conscious Eaters; the Uninterested; and the Rejecters; all of these could be addressed by public health policy with individually tailored messages. The empirical results led to rejection of the original Three-Factor Eating Questionnaire (TFEQ-R21), while the TFEQ-R16 model could be validated on a representative sample of adults, for the first time in Hungary.