bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of antimicrobial therapy on progression free survival of patients with non-small-cell lung cancer receiving checkpoint-inhibitor- and chemotherapy
Authors: Uhlenbruch Mark , Krüger Stefan
Published: June 2021

BackgroundCheckpoint-inhibitor therapy (CPI) has significantly changed therapy in non-small cell lung cancer (NSCLC) in recent years. There is some data that the effect of CPI-therapy is influenced by the microbiome. Little is known about the influence and timing of antimicrobial therapy (AMT) on the microbiome mediated effect on CPI therapy.Patients and methodsWe retrospectively analysed 70 patients (age 68 ± 9,2y) with NSCLC stage IV. Patients were treated according to the guidelines with either CPI alone (pembrolizumab, nivolumab, atezolizumab) or chemotherapy (platin doublet or docetaxel / nintedanib or pemetrexed). We registered patients’ characteristics including presence and timing of AMT. Group 1 consisted of 27 patients with AMT in the month before CPI- or chemotherapy, group 2 were 30 patients with AMT during CPI- or chemotherapy, and group 3 were 43 patients without AMT.ResultsGroup 1–3 showed comparable patients characteristics. Using cox-regression analysis, we found that AMT in the month before CPI resulted in a decreased progression free survival (PFS) compared to patients with CPI and no AMT (14 ± 1.56 vs. 5 ± 0.99, p = 0.005, 95% CI: 0.13–0.67). In patients, who were treated with chemotherapy alone, there was no difference in PFS in those with or without AMT in the month before therapy (5+/- 0,99 vs. 6 ± 0.81 months, p = 0.3). Interestingly, AMT during chemotherapy or CPI therapy showed no effect on PFS.ConclusionsIn a real-life setting, we found that AMT reduces PFS when given in the month before CPI therapy. AMT before chemotherapy and during CPI and chemotherapy seems not to influence PFS. The best PFS was seen in patients without AMT before CPI therapy. This implies the need for an even more restrictive use of AMT in the context of patients with NSCLC stage IV disease.
Malignant Gastrointestinal Neuroectodermal Tumor in the Right Atrium: The First Case Report Presenting with an Extra-Gastrointestinal Mass
Authors: Li Zhiwen , Pu Xiaohong , Fu Yao , Li Lin , Xu Yuemei , Fan Xiangshan
Published: June 2021

Background: Malignant gastrointestinal neuroectodermal tumor is an extremely rare soft tissue sarcoma which was firstly described in 2003 but until recently it had been designated as a definite new entity. According to the previous literatures, Malignant gastrointestinal neuroectodermal tumor was almost exclusively occurred in gastrointestinal tract.Case presentation: A 62-year-old male showed a mass in right atrium and the occupying mass was founded on the right ventricular diaphragm and involved the right atrium along the coronary sinus during the operation. Microscopically, the tumor characterized by the solid sheet and pseudopapillary focally architectures, and was composed of small to medium cells with round or oval nuclei, variable amount of eosinophilic or clear, and frequent mitotic figures. Immunohistochemically, the neoplastic cells were positive for S100 and SOX-10 but negative for HMB-45, A103 and CD99. EWSR1-AFTF1 rearrangement was detected by fluorescence in situ hybridization and further confirmed involving fusion of EWSR1 exon 8 with ATF1 exon 4 by whole transcriptome sequence analysis.Conclusions: This is the first case report of extra-gastrointestinal Malignant gastrointestinal neuroectodermal tumor that occurring in the right atrium，which remind of the new prospect of the tumor location.
Measuring agency in children: the development and validation of the War Child Agency Assessment Scale - Palestinian version (WCAAS-Pal).
Authors: Veronese Guido , Pepe Alessandro , Cavazzoni Federica , Obaid Hania , Yaghi Shaher
Published: June 2021

In the present article, we aimed at construing a new quantitative measure of children's agency in Palestine. Within a socio-ecological and culturally and contextually informed perspective, the study introduces the development of a new instrument to investigate and evaluate children's agentic practices within their living contexts and their daily lives. First, we evaluated the model of measurement of WCAAS-Pal using a sequential exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). Following the principles of testing a quantitative measure in the context of the dual-frame sampling method, the process of validating the quantitative measure was conducted on a group of 1,166 Palestinian children aged 9 to 14 years (m = 11.58, sd = 1.54). Second, a sample of 251 Palestinian children aged between 9 and 14 years (m = 11.82, sd = 1.53) was used to compute the reliability of the instrument along with both convergent and divergent validity using the Children Hope Scale and the Children Revised Impact of Event Scale-Arabic Version measures, respectively. The results of the EFA suggested a baseline seven-factor structure to be further assessed via CFA. A complex web of agency domains that might contribute to the child psychological functioning when forced to leave in conditions of ongoing threat and military violence emerged from the analysis.
Microcomputer software simulating problems in Rh immune globulin prophylaxis and hemolytic disease of the newborn
Authors: Hardman P.K. , Hardman J.T. , Brown P.J. , Borek D.A. , Beck M.L.
Published: June 2021

Our purpose was to develop educational software that would simulate laboratory investigation of problems in Rh immune globulin prophylaxis and hemolytic disease of the newborn. An interactive, blanching style program was developed using a 256K Personal Computer (International Business Machines, Boca Raton, FL). The software has been used in over 125 institutions for preprofessional and continuing professional education.
Immunohematology
1991;1:12–15.
Procedural errors in antibody identification
Authors: Strohm P.L. , Smith P.J. , Fraser J.M. , Smith J.W. , Rudmann S.V. , Svirbely J.R. , Miller T.E. , Blazina J.F. , Kennedy M.S.
Published: June 2021

In experimental studies of students and line technologists performing antibody identification procedures, both groups made errors. These errors included, at times, either failing to identify an antibody or misidentifying the specificity(ies). A prospective study was undertaken to identify errors made in a laboratory setting. Errors were classified as 1) failing to follow protocol (procedural error) or 2) arriving at the wrong answer (misidentification error). Over a 1-year period, 1,057 workups were reviewed. There were 41 (3.88%) procedural errors and no misidentification errors. In 25 workups (61% of errors), the selection of cells to rule out underlying alioantibody(ies) was in error. The remaining 16 involved various “slips” (minor mistakes or memory lapses) and clerical errors. Based on an analysis of the probable causes of these errors, potential solutions include 1) developing computer aids to detect “rule-out” errors or missing tests results; 2) providing timely, carefill review of workups before transfusion; and 3) designing better panel layout and cell selection.
Immunohematology
1991;1:20–22.
Indicators of clinically significant red cell antibodies produced by sensitized lymphocytes in liver transplant patients
Authors: Calhoun B. , Pothiawala M. , Musa G. , Baron B.
Published: June 2021

It has been documented that transplanted livers can carry sensitized lymphocytes that subsequently produce red cell antibodies. We evaluated immunohematological variables in liver donors and recipients for indicators that might be predictive of serological red blood cell (RBC) destruction mediated by the passenger lymphocytes. Organ donor sera with antibody scores greater than (>) 60 correlated with a positive direct antiglobulin test (DAT) and need for increased RBC transfusion in liver transplant recipients. We therefore propose an antibody screen on all potential liver donors and titration of unexpected alloantibodies; titration of ABO antibodies of liver donors who demonstrate minor ABO-incompatibilities with their recipients; and, when needed, transfusion of group O RBCs to recipients of livers from donors with minor ABO-incompatibility who have antibody scores > 60.
Immunobematology
1991;2:37–39.
Use of a modified acid/EDTA elution technique
Authors: Byrne P.C.
Published: June 2021

A modification of the acid/EDTA elution technique was recently developed at the International Blood Group Reference Laboratory, Bristol, UK. By altering the volumes of reagents used, maximization of elution of antibody could be achieved without loss of red cel] integrity.
Immunobematology
1991;2:46–47.
The incidence of WESa in 3,072 donors in the United States
Authors: Copeland T.R. , Smith J.H. , Wheeling R.M. , Rudolph M.G.
Published: June 2021

The rare red cell antigen, WESa, which is controlled by an autosomal dominant gene, was reported by Sistonen et al.1 to have an incidence in the Finnish population of 0.56 percent. A study was undertaken to determine the incidence of the WESa antigen within the United Stales. A total of 3,072 donor samples were obtained for testing from eight different geographical locations. It was determined that the incidence of the WESa antigen in the white donor population tested was 2 per 1,610 or 0.12 percent and in the black donor population tested, 7 per 1,460 or 0.48 percent. In the random population the incidence would be 0.29 percent.
Immunohematology
1991;7:76–77.
Case reports: red blood cell autoantibodies mimicking alloantibodies
Authors: Domenan R.E. , Clarke D A.
Published: June 2021

The phenomenon of autoantibodies mimicking alloantibodies is rare and challenging. This report describes several unusual cases of mimicking autoantibodies and reviews the literature.
Immunohematology
1991;7:98–101.
Human leukocyte antigens (HLA) class I (Bg) on red cells studied with monoclonal antibodies
Authors: Giles C.M.
Published: June 2021

Monoclonal antibodies, capable of detecting monomorphic epitopes on HLA class I polypeptides and beta-microglobulin (β2-M), have been used by a variety of techniques to ascertain the type of structure detected on red blood cells (RBCs). Hemagglutination with class I monoclonal antibodies confirmed the reported relationship between Bg blood groups and HLA. It also established that the expression of HLA on RBCs which do not have nuclei is not normally strong, but may be enhanced in patients, notably those with systemic lupus erythematosus (SLE). Estimates of the number of class I molecules on mature RBCs by a radioligand-binding assay have confirmed that all HLA-B7 (Bga) individuals have higher numbers but that SLE patients usually have the most (1240/RBC). Class I polypeptides were not elevated in the plasma of SLE patients and all RBCs lost molecules on aging in the circulation. These two facts suggest that HLA on RBCs is not acquired from plasma. When RBCs from SLE patients were immunoblotted with monoclonal antibodies, a complete 45 kDa intrinsic transmembrane heavy chain of HLA class I and a light chain of 11 kDa (β
2-M) were detected. Chloroquine treatment and acid elution of RBCs did not remove HLA class I but only β
2-M. As most antibodies recognize epitopes that depend on close association of class I with β
2-M, the lost reactivity of treated RBCs may be understood.
Two cases of autoantibodies that demonstrate mimicking specificity in the Duffy blood group system
Authors: Harris T.
Published: June 2021

Two transfused Caucasian patients presented with possible delayed transfusion reactions. Both patients demonstrated an anti-Fya (Fy1) plus anti-Fyb (Fy2) pattern of reactivity in their sera. The patients’ red blood cells (RBCs) were Fy:1,–2,3. Both had positive direct antiglobulin tests (DAT) with anti-IgG and -C3d. The serum antibodies reacted with the patients’ RBCs drawn when the DATs were negative Both patients’ serum samples showed reactivity with Fy:1,–2 (1 +), Fy:–1,2 (3+), Fy:1,2 (3+) RBCs at the antiglobulin phase (ACT) but were nonreactive with Fy: –1, –2 RBCs. The anti-bodies in both cases were nonreactive with papain- or ficin-treated RBCs -and reacted with Rhnull RBCs, which ruled out anti-Fy3 and anti-Fy5, respectively. These cases suggest mimicking autoantibody specificities in the Duffy system. One case may indicate that the degree of reactivity is dependent on the Duffy phenotype of the RBCs tested (Fy: –1,2 > Fy:1,2 > Fy: –1, – 2). An unusual characteristic seen in both of these cases was hemolysis in the EDTA cell samples but none in the clotted samples.
The P1H antigen and antibody
Authors: Moores P.P.
Published: June 2021

P1H, a newly discovered compound antigen associated with both the ABO and P systems, occurs in approximately 7 percent of Natal (South African) blacks. The compound antigen is evident only when the red cells have exceptionally strong expression of both P1 and H antigens, and it is apparently a dominant character. The antigen is thought to originate by steric rearrangement in the molecule, or to be the product of competition between P
1 and H gene transferases for the available paragloboside. The corresponding antibody, anti-P1H, has been made by both P2 and P2 people and is a weak cold agglutinin. It is not adsorbed by red cells carrying either strongly expressed P1 or H antigens, but is adsorbed by and eluted from P1H+ red cells sensitized by anti-P1H. The antibody is inhibited by P1 but not by H, Lewis, or Sda substances.
Immunohematology
1993;9:7.
En(a–) phenotype in a Japanese blood donor
Authors: Okubo Y. , Seno T. , Yamaguchi H. , Miyata Y. , Green C.A. , Daniels G.L.
Published: June 2021

The first Japanese En(a–) individual (T.N.) was found by screening red cells from 250,000 Japanese blood donors with monoclonal anti-Ena. His serum contained no atypical antibodies and his partial red cell phenotype was M–N–S+s–, although a trypsinresistant N antigen was detected. His red cells were En(a–) and Wr(b–), as determined by various human and mouse monoclonal antibodies. The absence of glycophorin A (GPA) and the presence of apparently normal glycophorin B (GPB) were demonstrated by immunoblotting with antibodies to the extracellular and cytoplasmic domain of GPA and to epitopes common to GPA and GPB. Sialic acid levels of T.N.’s intact red cells were substantially lower than those of control MN cells. Serologic tests suggested that both of T.N.’s parents were heterozygous for a recessive GPA deficiency gene.
Immunohematology
1993;9:105.
Red cell antigen stability in K3EDTA
Authors: Westhoff C.M. , Sipherd B.D. , Toalson L.D.
Published: June 2021

Commercial blood grouping reagents are not approved for testing EDTA anticoagulated blood specimens that are more than 48 hours old. Many studies on the stability of blood group antigens in other anticoagulants have been reported, but none are available for EDTA. This study was undertaken to assess whether current commercially available blood grouping reagents give acceptable reactions with red cell antigens when the cells are stored for extended periods in EDTA We defined acceptable reaction strength to be 2 + (score 8). As expected, the A, B, and D reactions were very stable with red cells stored for 60 days. All antigens except Lea exhibited 2+ (score 8) or greater reactions at day 14, and at day 21 only the Lea, Fyb, and e antigens were less than 2+. On day 60, twelve of twenty-one antigens tested still exhibited 2+ or greater reactions. This study shows that antigen reactivity for red cells collected and stored in EDTA is at least equal to that for clotted specimens. These red cells can be used for reliable antigen typing for at least 14 days, and even longer for most antigens.
Immunohematology
1993;9:109.
Review: the Lutheran blood group system–1991
Authors: Poole J.
Published: June 2021

The Lutheran blood group system, comprised of 18 antigens with four pairs of alleles at closely linked loci, is complex. This article outlines current knowledge of the Lutheran system with special reference to recent serologic, Immunochemical, and clinical findings.
Immunohematology
1992;8:1–8.
Case report: serologic confirmation of paroxysmal cold hemoglobinuria
Authors: Putnam C.
Published: June 2021

A child with a history of recent viral infection entered the hospital with severe anemia, hemoglobinuria, and suspected autoimmune disease, Serologic findings included a positive direct antiglobulin test and incompatible crossmatches. Extensive studies, including a Donath-Landsteiner test, confirmed paroxysmal cold hemoglobinuria. The child was transfused several times with washed red blood cells compatible by prewarm technique. Although hemolysis continued after each transfusion, he stabilized and went home 5 days after his hospital admission. He reportedly made a complete recovery.
Immunohematology
1992;8: 19–21.
Failure to detect a prozoning anti-Fya in the serum of a chronically transfused patient
Authors: Sizemore J.C. , Sammons T.D. , Clanton J.N.
Published: June 2021

A 78-year-old white male presented to our facility with vascular occlusion. He was Group A, D-positive, with a negative indirect antiglobulin test (antibody screen). Records at our facility, 4 years prior to this admission, indicated a history of anti-Fya, and Fy(a−) units were provided. A referring hospital had transfused the patient for “chronic anemia” (1-3 units weekly for 2 years), and he had received eight units (untested for Fya) immediately prior to his transfer to our facility for acute hemorrhage. Only the presence of anti-IH in the serum was documented. To detect possible immune red cell destruction, the patient was monitored by our facility at 24-hour intervals with a direct antiglobulin test and antibody screen. On day 4, a 4+ anti-Fya was identified in the serum and the DAT was negative. Three days later anti-K was also identified. The serologic picture remained unchanged for 10 days, when the DAT became positive. Concurrently, a mixed-field Fya typing (on the patient’s chloroquinediphosphate-treated cells) was detected. Repeat Fya typing of all units transfused at our facility confirmed their Fy(a-) status. From the day of admission, eluates on every sample, using a low pH technique, showed anti-Fya specificity. Titration of the anti-Fya but not in neat serum. Although a prozoning phenomenon is uncommon, thi in the sample drawn on admission reacted from a dilution of 4 through 2,048 s case study suggests that a prozoning anti-Fya present in the patient’s serum may have been a contributing factor to his “chronic anemia.”
Intmunobenurtology
1992;8:44–46.
Case report: mixed-field agglutination in a patient with a weak D antigen presenting as a possible fetal-maternal hemorrhage
Authors: Unger P.J. , Rapini J. , DelMores F. , Howard C. , Znavor J. , Behzad O. , Rossi E.C.
Published: June 2021

A gravida 1, para 0, 17-year-old black female was found on pre-natal testing to he group O, Duu, the latter test showing many unagglutinated cells. Because of the mixed-field appearance, the patient was thought initially to have bad a fetal-maternal hemorrhage. Additional red cell typings were performed, but no other apparent mixed-field reactions were observed. The Kleihauer-Betke test and hemoglobin electrophoresis indicated that the mixed-field agglutination was not due to a fetal-maternal hemorrhage. Thus, the finding of a mixed-field D typing could he explained best by a weak D antigen.
Immunohematology
1992;8:77-78.
A FATAL OUTCOME OF A NEONATAL DILATED CARDIOMYOPATHY: EVOLUTIVE NEONATAL LUPUS OR EARLIER CHILDHOOD- ONSET SYSTEMIC LUPUS? A CASE REPORT
Authors:   Cardiologist and PH D at Ibn Zohr University, Department of Biology Department of Cardiology and Internal medicineInzgane Provincial Hospital, Agadir, Morocco., Benyamna Ilham
Published: June 2021

Neonatal lupus is a rare congenital syndrome resulting from placental passage of maternal antibodies against SSA/Ro and/or SSB/La to the fetus. It is a generally benign condition, the cardiac involvement determining the prognosis. NNL is rarely manifested by isolated cardiomyopathy. The subsequent evolution towards systemic lupus is rare and unpredictable. We report the case of a daughter from a non-consanguineous marriage with healthy parents who presented a dilated cardiomyopathy in the first months of her life complicated by several outbreaks of heart failure. The spontaneous evolution was marked by the occurrence of skin lesions of the face and arms at the age of 10 years, then by the installation of episodes of hydrous retention at the age of 12 years complicated by an acute renal insufficiency with a rapid fatal outcome at the age of 15 years. ANA antibodies rate was at the threshold of positivity, antiDNA and ANCA were not detectable.C3 rate was low. Although a genetic cause can never be ruled out, the diagnosis was a systemic erythematous lupus SLE (an evolution of an eventual NNL or a childhood-onset systemic lupus). We propose a decision tree for the management of neonatal cardiomyopathy NCMP as a synthesis of the literature.The search for anti SSA/SSB must be part of the check-up usually requested at the time of pregnancy. In addition, we must strengthen the knowledge of the medical profession, especially in the proximity health centers, on rare diseases for a better management of patients.
CLINICOPATHOLOGICAL EFFECTS OF HEAT STRESS ON BLOOD PICTURE OF JAPANESE QUAILS
Authors:   Livestock & Dairy Development Department Khyber Pakhtunkhwa Pakistan (Research Wing)., Anwar Khurshaid , Smark Nakash ,   Livestock & Dairy Development Department Khyber Pakhtunkhwa Pakistan (Research Wing)., Khan Sartaj ,   Livestock & Dairy Development Department Khyber Pakhtunkhwa Pakistan (Extension Wing)., Ullah Kalim ,   Livestock & Dairy Development Department Khyber Pakhtunkhwa Pakistan (Research Wing)., Ur Rashid Haroon ,   Livestock & Dairy Development Department Khyber Pakhtunkhwa Pakistan (Research Wing)., Salman Siddiqui Hazrat ,   Livestock & Dairy Development Department Khyber Pakhtunkhwa Pakistan (Research Wing).
Published: June 2021

This study aimed to evaluate the effects of heat stress on quail hematological parameters two published papers on quails in 2013 were studied, analyzed and compared. Broiler Japanese quails (Coturnix coturnix japonica) were exposed to high ambient temperature (340C, 8hr/d, 0900-1700hr) in both papers. An increase in values of red blood cells count, white blood cells count, lymphocytes, heterophils and lymphocytes (H/L) ratio, Monocytes, packed cell volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration were recorded while a lower values of heterophils, basophils, eosinophils, mean corpuscular volume and hemoglobin concentration than normal were recorded in groups exposed to heat stress (340C) on day 42 in Japanese quails (Coturnix coturnix japonica). Hemoglobin concentration was least affected. The obtained results indicated that, rearing quail birds under high environmental conditions during the fattening period has a great adverse effect on blood parameters. To help maintain Japanese quail as an essential animal model further heat stress related research on modern ways is needed.
INTERNALIZATION OF LOCAL CULTURE OF TERNATE, ERODED BY GLOBALIZATION TO STRENGTHEN THE CHARACTER OF THE NATION IN THE NEW NORMAL ERA (A LITERATURE REVIEW)
Authors:   Khairun University, Ternate, Indonesia., Djumat Irwan , Hayun Subhan ,   Pacific University of Morotai, Indonesia.
Published: June 2021

This research is a library research. The analysis used is content analysis that focuses on academic manuscripts in the form of books, articles, and writings in papers related to the internalization of Ternates local culture which has been eroded by globalization to strengthen the character of the nation. Internalization according to Ihsan is an effort made by a person to insert values Ã¢Â€Â‹Ã¢Â€Â‹(local cultural values) into the soul of a person or group of people so that these values Ã¢Â€Â‹Ã¢Â€Â‹can be manifested in him. The internalization of the local Ternate culture takes place in three institutions that support each other, go hand in hand, and go hand in hand in the family, school and community. The internalization of local Ternate culture must take place continuously in peoples lives with an emphasis on character aspects (attitudes, mindsets, and patterns of action), especially the nations generation. Ternates local cultural values Ã¢Â€Â‹Ã¢Â€Â‹are reflected in the values Ã¢Â€Â‹Ã¢Â€Â‹that exist in community life, including: greeting each other (standard togor / sibinyafo), reminding each other (makuwaje), paying attention / caring (raw faduli), mutual cooperation (babari ), help each other (lilian), visit each other (silaturrahim),and respect each other (baising). The internalization of local Ternate culture in the New Normal Era is an effort to make Ternate people in general and especially the younger generation to become citizens who are polite, civilized and tolerant, and strong in facing various threats that come from outside (global culture). The cultural values Ã¢Â€Â‹Ã¢Â€Â‹of Tara No Ate (Ternate) which originate from the traditional social values Ã¢Â€Â‹Ã¢Â€Â‹of the Ternate community itself must become an integral part of the nations culture that cannot be separated from various generations, so that the success of national character development must be based on local values. to create social harmony.
HEALTH-RELATED QUALITY OF LIFE (HRQOL) IN OLDER ADULT SUBJECTS WITH KNEE OSTEOARTHRITIS PAIN
Authors:   Department of Geriatric Mental Health, KGMU, Lucknow, India and Department of Orthopaedic Surgery, KGMU, Lucknow, India., K.J Nimitha , Singh Bhupendra ,   Department of Geriatric Mental Health, KGMU, Lucknow, India and Department of Orthopaedic Surgery, KGMU, Lucknow, India., Shyam Gangwar Radhey ,   Department of Geriatric Mental Health, KGMU, Lucknow, India and Department of Orthopaedic Surgery, KGMU, Lucknow, India., Srivastava RN ,   Department of Geriatric Mental Health, KGMU, Lucknow, India and Department of Orthopaedic Surgery, KGMU, Lucknow, India., Tripathi Rakeshkumar ,   Department of Geriatric Mental Health, KGMU, Lucknow, India and Department of Orthopaedic Surgery, KGMU, Lucknow, India.
Published: June 2021

Aim of the study: The study aims to find the health-related quality of life (HRQoL) in older adult subjects with knee osteoarthritis pain. Material and methods: A cross-sectional, telephonic study was done on knee osteoarthritis subjects above 50 years of age. Socio-demographic scales and details,(ShalliBavoria, et al., 2020) i.e., WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index), SF-12 (Short Form survey), PHQ-9 (Patient Health Questionnaire) et al were applied( Soo-Hyun Park and Byeong-Hun Kang., 2020). Information was retrospectively compiled and a semi-structured proforma was selected to gather the clinical variables. Results: Results were identified by domains of Health related quality of life.Results showed that there is significant difference in general health related quality of life based on the KL grading of KOA.(P=0.02,P=0.04)Study concluded that general HRQoL worsens with higher grading of KOA.The results showed that there was a substantial discrepancy witnessed between males and females where females encountered more pain.As stiffness increases HRQoL decreases. More severity of pain was observed in depressed people.(Roger B. Fillingim, et al., 2020) Conclusion: Daily challenges and actions, of which some may be unusual to sufferers in a pastoral setting in India, underlie sedentary and effective strategies to Osteoarthritis and its control. The study concluded that a significant difference in pain and general quality of life-based on the KL grading of KOA (P=0.02, P=0.04) was observed.(Hye-Young Shim, etal, 2018) It was also found that there is a considerable difference in pain based on the duration of ]knee osteoarthritis (P=0.05).( Aliasghar A. Kiadalir, et al., 2017).
EVALUATION OF PATIENT SATISFACTION IN PRECISION ATTACHMENT-SUPPORTED OVERDENTURES AND CONVENTIONAL OVERDENTURES THROUGH VERBAL RATING SYSTEM
Authors:   Post Graduate Student, Department Of Prosthodontics, Crown & Bridge, Government Dental College & Hospital ,Srinagar, J&K., Ahmad Hakeem Abrar , Ahmad Shah Shabir ,   Professor, Department Of Prosthodontics, Crown & Bridge & Head Dental Materials, Government Dental College & Hospital ,Srinagar, J&K., Shazana Nazir Qazi ,   Associate Professor, Department Of Prosthodontics, Crown & Bridge ,Government Dental College & Hospital, Srinagar, J&K., Kour Bali Sandeep ,   Professor & Head, Department Of Prosthodontics, Crown & Bridge, Government Dental College & Hospital, Srinagar, J&K.
Published: June 2021

Teeth loss is a traumatic experience. It disturbs the total integrity of the masticatory system. Its successful rehabilitation should address a range of biomechanical problems, tolerances, and perceptions. Precision attachment-supported over Dentures with two teeth retained in canine region is a predictable treatment option in edentulous mandible rather than conventional complete denture as it offers increased retention, stability, comfort, bone preservation, maintenance of proproception and patient compliance. This study was carried out to determine patient satisfaction with precision attachment-supported overdentures and conventional overdenture and its impact on the treatment outcome. Material & Methods: Twenty(20) edentulous patients were randomly divided into two groups to receive precision attachment -supported overdentures and conventional overdenture in mandibular arch. Questionnaires were given to the patient after treatment at 6 and 12months interval. Data collected were statistically analyzed. Results: Results obtained from this study show that patients with precision attachment -supported overdentures were more satisfied with the treatment outcome, and there was a significant difference in patient satisfaction between the two groups.
EDGE COMPUTING: THE PROMISES IT HOLDS AND MARKET DYNAMICS
Authors:   Ericsson., Ibne Tahasin Zulkernyne
Published: June 2021

The data driven societies pushes for more decentralized management to overcome data storage overhauls and faster transmission spreads in various data streams. As wireless technology is getting more advanced, there is a need to reconsider data hierarchical restructuring through edge computing, to pave the way for better latency, operation efficiency, speed, reliability, and versatility. Already, video and gaming technologies have benefited from edge technologies by streamlining their services delivery as well as boosting their revenue growth. However, lack of standard thwarts unified development and application of edge computing at global level due to defragmented standards. As such, enterprises that have already purged into edge computing such as AWS, Google and Microsoft need to embark on more collaborative approaches to ensure unified standards in edge computing developments.
ETHNO-ARCHEOLOGICAL RESEARCH IN THE FERGANA VALLEY
Authors:   Andijan Machine Building Institute Professor, Doctor Of Historical Sciences., Abdullaev Ulugbek
Published: June 2021

This article focuses on the status and preliminary results of ethnoarchaeological research in the Fergana Valley. It provides an ethnographic analysis of material found by archaeologists in the Fergana Valley. In particular, the article examines the settlements, clothing and household items of the ancient peoples of the valley in the field of ethnoarcheology.
DEVELOPMENT OF HUMAN CAPITAL AND ENTREPRENEURIAL NEEDS OF THE POPULATION IN UZBEKISTAN
Authors:   Andijan Machine Building Institute Department of Humanities PhD in Economics, Associate Professor., Muhammadamin Abduvasitovich Akhunov
Published: June 2021

The article emphasizes the need for the state to pay more attention to the development of human capital in Uzbekistan, to reduce unemployment among the population, as well as to abandon poverty and livelihoods. Reflections and suggestions were made on the role and importance of entrepreneurship, home-based work and the correct use of land in solving these problems by shaping the entrepreneurial needs of the population. In particular, special attention is paid to the education of young people.
CREATING MODERN FORMS OF LABOR MARKET DEVELOPMENT
Authors:   Associate Professor of Andijan Machine Building Institute., Bazarova Gulnora
Published: June 2021

This article examines the scientific and theoretical aspects of increasing competitiveness in the regional labor market. The example of Tashkent region classifies an effective method of effective management of the labor market based on the creation of cluster structures in the mecha market. Scientific proposals and practical recommendations have been developed to address the shortage of qualified personnel based on the formation of cluster structures in the development of the regional labor market.
TROCHANTERITE TUBERCULEUSE REVELEE PAR UN ABCES DU CREUX POPLITE A PROPOS DUN CAS ET REVU DE LITTERATURE
Authors:   Service De Chirurgie Orthopedique, Hopital Ibn Tofail, CHU Med VI, Marrakech, Maroc., Lahmam H. , Ait El Ghali H. ,   Service De Chirurgie Orthopedique, Hopital Ibn Tofail, CHU Med VI, Marrakech, Maroc., Ayyadi H. ,   Service De Chirurgie Orthopedique, Hopital Ibn Tofail, CHU Med VI, Marrakech, Maroc., Chafik R. ,   Service De Chirurgie Orthopedique, Hopital Ibn Tofail, CHU Med VI, Marrakech, Maroc., Elhaoury H. ,   Service De Chirurgie Orthopedique, Hopital Ibn Tofail, CHU Med VI, Marrakech, Maroc., Madhar M. ,   Service De Chirurgie Orthopedique, Hopital Ibn Tofail, CHU Med VI, Marrakech, Maroc., Najeb Y. ,   Service De Chirurgie Orthopedique, Hopital Ibn Tofail, CHU Med VI, Marrakech, Maroc.
Published: June 2021

Nous rapportons un cas rare dÂ’une trochante?rite tuberculeuse ayant e?te re?ve?le?e par un abce?s du creux poplite. Il sagit dÂ’un Patient de sexe masculin, age de 58 ans et presentant une masse du creux poplite gauche depuis 4 mois. LÂ’interrogatoire : notion de douleurs en regard du grand trochanter gauche depuis 15 ans. LÂ’examen physique a note? une tumefaction du creux poplite gauche avec issue de liquide purulent a? travers une fistule ainsi quÂ’une douleur a? la palpation de la region trochante?rienne, apres confirmation du diagnostic par des bilans paraclinique ( biologique et radiologique). Le traitement optimal a consiste a administrer des antibacillaires pour une duree 12 mois. la chirurgie comme geste complementaire a ete indique avec resection large du grand trochanter et drainage de lÂ’abces . Une Reactivation de la maladie apres therapie anti bacillaire associee ou non a un traitement chirurgical a ete reportee dans la litterature, de ce fait un suivi regulier est donc indispensable. En conclusion le diagnostic de trochanterite doit etre evoquer devant toute douleur, tumefaction et ou fistule de la region trochanteriernne. Le traitement reste medical a base dantibacillaires, la chirurgical trouve son interÃªt dans les cas evolues et permet de raccourcir lÂ’evolution.
MAIN ENGINEERINGSPROPRETIES OF STABILISED EARTH BLOCK BRICKS FORMULATED WITH SOILS FROM NDJAMENA-CHAD
Authors:   Laboratoire dEtudes et de Realisation en Techniques Industrielles (LERTI /FSEA). Universite de NDjamena - Tchad., Bassa Bruno , Karka Bozabe Renonet ,   Laboratoire de Batiments et de Travaux Publics (LBTP). ENSTP - Tchad., Issak Adoum ,   Laboratoire dEtudes et de Realisation en Techniques Industrielles (LERTI /FSEA). Universite de NDjamena - Tchad.
Published: June 2021

The most used bricks in house building in NDjamena, city of Chad which is situated in semi dry arid area with 600 millimeters of pluviometry per year and 50 Â°C as highest temperature, are raw clay bricks, terracotta bricks or bricks in ciment block. The raw clay bricks have strong sensibility in water and weak resistance to compression. The terracotta and cement block bricks have high thermal conductivity contrary to the adobe and their manufacturingcontribute to destroy the environment. The aim of this paper is to search Stabilised Earth Block (SEB) bricks whichare made with clay, sand and few percent of cement and respond to climatic, environmental and economic constraints. Therefore, some bricks are built in mixing differentspercents of sand and clay (M1 : 40% sand and 60% clay, M2 : 50% sand and 50% clay, M3 : 60% sand and 40% clay, M4 : 70% sand and 30% clay, M5 : 30% sand, 30% slime and 40% clay, and M6 : 40 % sand, 20% slime and 40% clay) for obtaining physical stabilizationand adding 8%, 10% or 15% of cementin each type of brick for the chemical stabilization. Theuse of moulding press machine grants already the mechanical stabilization to these bricks. Proctor test has allowedto retain M1, M3 and M4 for searching the best values of the rate absorption of water by capillarity , the resistance in compression and the thermal conductivity of these bricks. The results of tests show bricks M3 with 10% of cement have the good values 21,23 g.cm-Â².min-1/2 of rate absorption, 3,82 MPa of resistance in compression and 0,5W.m-1.Â°K-1 as thermal conductivity.
SPECTRUM OF MUSCULOSKELETAL DISCOMFORTSIN PREGNANT WOMEN AND IMPACT OF ANTENATALEXERCISES OR POSTURAL CARE ON STATUS OF RELIEF: A SYSTEMATIC REVIEW STUDY
Authors:   Asst. Professor Department of Physiotherapy, UIHS, CSJM University, Kanpur., Shukla Neha , Shukla Puja ,   MPT Research Scholar.
Published: June 2021

Pregnancy is a normal physical state of womens life when they carried a 9 month developmental stages of the foetus. On these durations some pregnancy induced changes leads normal signs naturally but there is an increased risk of musculoskeletal pain or discomforts associated with increase of uterine size and mental stress of pregnant women, needed non-medicines approached like antenatal physiotherapy care. These possible pain or discomforts can make difficult to carry the pregnancy may leadsome complications. Various research studies are point out these problems of pregnant women and find out the triggers. Some studies show the spectrums of these musculoskeletal problems during pregnancy period. Various case studies are assuredtheparticular physiotherapy techniques as antenatal exercises have good impact on relief of respective musculoskeletal pain.Various researches are also covered some another aspects of musculoskeletal problems during pregnancies. In thepresent study an attempt has been made to comprehensive analysis of these review studies to identify the most common musculoskeletal problems in different stages of pregnancy and efficacy of physiotherapy techniques and antenatal exercises to overcome the problem. It was found in the spectrum analysis that most of the women (68.33 %) faced this problem during their pregnancy. On the analysis of most commonmusculoskeletal problem, the mean percent of reviews reveals showed that the most of the women found to be in muscle cramps and pain in neck and shoulder during I trimester whereas maximum women had low back pain (42.87 %) and pelvic girdle pain (11.65 %) on II and III trimester respectively. The satisfactory impacts of antenatal exercises were observed in different musculoskeletal pain by different techniques of Physiotherapy.These results can utilize to make suggestions and recommendations foradoption of suitable physiotherapy techniques in pregnancy to avoid the problem.
BREAST RECONSTRUCTION AFTER MASTECTOMY FOR BREAST TUMOR : ABOUT 24 CASES
Authors: Mohamed Elmehdi Sahibi , Ismail Zineddine , Imane Yafi , El Mehdi Mahrouch , Mehdi Elgueouatri , Benlaasel Oumnia Ait , Driss Elamrani Moulay , Banchamkha Yassine
Published: June 2021

The mutilating surgery for breast cancer causes deep somatic and psychological sequelae. Breast reconstruction can mitigate these effects and permit the patient to help rebuild their lives. Our work is a retrospective study over 7 years, from 1st January 2012 to 31st December 2019, covering 24 cases of reconstruction breast collected in the department of cosmetic and reconstructive plastic surgery of ERRAZI hospital in Marrakech.This work presents through these first operated cases, the results obtained as well as an illustrated panorama of the different surgical methods used in the service during the different surgical times.It also Conducts a review of the literature, discussing our findings and reviewing the techniques currently used in the various centers for breast reconstruction. Breast reconstruction is today one of the most successful plastic surgery, however a few women use it, often because of lack of information. Every day, the surgical teams demonstrate an increasingly technical skill, in their constant search for perfection. It is clear that it is at the level of information that efforts should be intensified.
RELATIONSHIP ENVIRONMENTAL SANITATION WITH THE INCIDENT OF PULMONARY TUBERCULOSISIN PUBLIC HEALTH CENTER SIKAKAP MENTAWAI ISLANDS
Authors:   High School of Health Sciences SyedzaSaintika Padang, West Sumatera, Indonesia., Sartiwi Weni , Sandra Rhona ,   High School of Health Sciences SyedzaSaintika Padang, West Sumatera, Indonesia.
Published: June 2021

Background:The achievement of countermeasures for tuberculosis treatment in Mentawai Islands District is still very low. This can be seen from the cure rate for new smear positive cases in 2016, which has not reached the target of 84.44%. While the data shows that of the 10 existing Puskesmas in Mentawai Islands District, the highest incidence of pulmonary Tuberculosis in Sikakap Health Center is 51 people. This study aims to determine the relationship between environmental sanitation with the incidence of pulmonary TB in Sikakap Health Center Mentawai Islands District in 2018. Methodology:This type of research is descriptive with a cross sectional study method. The population was all patients who visited the Sikakap Health Center who were examined by doctors the last 3 months (January to March 2018) totaling 315 people. A sample of 42 people was taken by simple random sampling method. Data collection was carried out through interviews using interview guidelines in the form of a questionnaire. Data analysis was univariate and bivariate using chi-square test. Results:Based on the results of the study found 59.5% of respondents experienced pulmonary Tuberculosis, 64.3% of respondents had environmental sanitation that did not meet the requirements. Statistically obtained the relationship between environmental sanitation with the incidence of pulmonary TB in Sikakap Public Health Center in Mentawai Islands District in 2018 (p = 0,024). Conclusion:Thereisasignificantcorrelationbetweenenvironmental sanitation with the incidence of pulmonary Tuberculosis. It is expected that health workers through the holder of the Pulmonary TB program to better screen patients who drop out of medication and improve counseling about prevention of pulmonary Tuberculosis.
PRODUCTION OF ANTINEOPLASTIC DRUGS FROM SOIL MICROORGANISMS
Authors:   Chaitanya Bharati Institute of Technology, Department of Biotechnology, Gandipet, Hyderabad-500075, Telangana, India., Obula Reddy C. , Damalla Deepika ,   Chaitanya Bharati Institute of Technology, Department of Biotechnology, Gandipet, Hyderabad-500075, Telangana, India., Ganga Divya ,   Chaitanya Bharati Institute of Technology, Department of Biotechnology, Gandipet, Hyderabad-500075, Telangana, India., Teja Divya ,   Chaitanya Bharati Institute of Technology, Department of Biotechnology, Gandipet, Hyderabad-500075, Telangana, India.
Published: June 2021

As number of cancer patients increasing, the number of chemotherapy treatments are also increasing. This analysis aims to provide a cutting-edge outline of the antineoplastic medications extracted from streptomyces. Streptomyces are the main source of antibiotic production. Antineoplastic medications moderate the pace of tumor development and postpone metastasis. The utilization and performance of the methods are discussed, with focus on the antineoplastic drugs. Streptomyces produces compounds and crude extracts which shows cytostatic reaction across different human cell lines like for breast carcinoma (MCF-7, MDA-MB-231 cell lines), (HepG2 cell lines) hepatic carcinoma, (DU 145 cell lines) prostate cancer and more.
SUBAMNIOTIC HEMATOMA : CASE REPORT AND REVIEW OF LITERATURE
Authors:   Pediatric Imaging Department, UHC IbnSina, Faculty Of Medicine, Mohamed V University, Rabat, Morocco., Lrhorfi Najlae , Moslih Hasnae ,   Pediatric Imaging Department, UHC IbnSina, Faculty Of Medicine, Mohamed V University, Rabat, Morocco., El Haddad Siham ,   Pediatric Imaging Department, UHC IbnSina, Faculty Of Medicine, Mohamed V University, Rabat, Morocco., Allali Nazik ,   Pediatric Imaging Department, UHC IbnSina, Faculty Of Medicine, Mohamed V University, Rabat, Morocco., Chat Latifa ,   Pediatric Imaging Department, UHC IbnSina, Faculty Of Medicine, Mohamed V University, Rabat, Morocco.
Published: June 2021

Subamniotic hematomais a classic placental lesion resulting from the rupture of chorionic vessels near the insertion of the cord. The development of these lesions is rarely reported in utero. We present the case of asubamniotichematomadiscoveredincidentally on obstetric ultrasound in a 28-year-old woman, primigestin her20th gestational week.
PARTICULARITIES OF SCIMITAR SYNDROME IN ADULT PATIENTS
Authors:   Resident of Cardiology Assigned to Intensive Care Unit,Department of Cardiology A, Ibn Sina University Hospital Center, Rabat, Morocco., Faid Soumia , Maliki Alaoui Amine ,   Resident of Cardiology Assigned to Intensive Care Unit,Department of Cardiology A, Ibn Sina University Hospital Center, Rabat, Morocco., Maryam Nadif ,   Resident of Cardiology Assigned to Intensive Care Unit,Department of Cardiology A, Ibn Sina University Hospital Center, Rabat, Morocco., Ibrahim Liban ,   Resident of Cardiology Assigned to Intensive Care Unit,Department of Cardiology A, Ibn Sina University Hospital Center, Rabat, Morocco., Sofia Kaddaf ,   Resident of Cardiology Assigned to Intensive Care Unit,Department of Cardiology A, Ibn Sina University Hospital Center, Rabat, Morocco., Fellat Nadia ,   PhD, interventional cardiologist,Deputy head of Cardiology Adepartment, Ibn Sina University Hospital Center, Rabat, Morocco., Fellat Roukia ,   PhD, Rhythmologist, Head of Cardiology Adepartment, Ibn Sina University Hospital Center, Rabat, Morocco.
Published: June 2021

Scimitar syndrome or Felsons veno-lobar syndrome is a very rare congenital disease characterized by a combination of cardiopulmonary abnormalities, including partial right-sided pulmonary venous drainage to the inferior vena cava, the inferior cavo-atrial junction, or low on the right atrium. We report the case of a 53-year-old female patient who presented with recent gradually worsening dyspnea. The diagnosis was suspected on the chest x-ray and confirmed on Cardiac echography andComputed Tomography scan that showed a wide collector gathering the three right superior pulmonary veins that joins the lower part of the superior vena cava, thus joining the right atrium while the right inferior pulmonary vein is drained into the inferior vena cava. The patient was treated surgically by performing a derivation of the right superior pulmonary venous collector to the left atrium with a tricuspid annuloplasty with a good outcome.