bluuebunny/crossref_metadata_2025 huggingface dataset:
Unleashing the Influence of Information Sharing, Technological Openness, and Corporate Innovation on Green Corporate Social Responsibility: A Way Toward Environmental Sustainability
Authors: Yi Xin , Tanveer Arifa , Bin Lee , Xue Yan
Published: October 2022

The current study investigates three important characteristics of corporate culture, i.e., information sharing, technological openness, and corporate innovation to address the research gap about how they affect corporate culture to enhance green corporate social responsibility in the automobile sector of China. The data were tested and examined using PLS-SEM. The findings indicate that information sharing, technological openness, and corporate innovation contribute to enhancing green corporate social responsibility. More precisely, the corporate culture encourages information sharing and innovation among employees and connects them to increased corporation operations that may facilitate the acquisition of advanced manufacturing skills. The study demonstrated that corporate culture is critical to effective corporate integration and that information sharing and corporate innovation tend to be powerful determinants of green corporate social responsibility. Additionally, the study emphasized that these characteristics are the source of corporate social responsibility and adopting these characteristics will assist corporations in enhancing the green corporate social responsibility.
Using Behavioural Economics to Analyse and Enhance Contraception Usage Decisions
Authors: Sarkar Rupa , George Tony Sam
Published: October 2022

Existent literature helped narrow down variables influencing modern contraceptive adoption (usage), a behaviour carrying enormous positive externality. Using finite population sample size formula and probability proportional to size method of sample selection, primary data was collected from participants using inclusion and exclusion criterions. Binary logistic regression model was used to predict probability of occurrence of dependent variable ‘usage of modern method of contraception’ being treated at a dichotomous outcome level. Predictor variables after confirming association by cross tabulation were introduced stepwise to build model subject to elimination of those variables adding insignificantly to the overall predictability of the model. Variables such as gender, education level, spousal influence, extended family influence, financial well-being and contraceptive information were found to significantly predict the probability of occurrence of the dependent variable. Except for financial well-being with three sub-categories, other independent variables were treated at dichotomous level. Income level was found to be an important predictor although found statistically insignificant. Non-contributory factors such as age, occupation and years of marriage were dropped. Post-model construction, borrowing ‘nudges’ from behavioural economics (BE) domain, strategies to nurture the significant context specific influencing variables, were articulated. BE was particularly preferred for its openness to the paradigm of non-rational behavioural choices.
Cultural Learning Among Pastoralist Children
Authors: Bira Temechegn G. , Hewlett Barry S.
Published: October 2022

Cultural learning is a key feature of culture and our humanity. Although studies exist on children’s learning in subsistence farmers and hunter-gatherers, comparable cross-cultural studies have not been conducted for pastoralists. The purpose of this paper is to identify and describe patterns of cultural learning in pastoralists and to compare these patterns to what we know about cultural learning in hunter-gatherers. The study utilizes 13 cultures coded as pastoralists in eHRAF World Cultures. The search located 198 texts in ethnographies with precise information on how pastoral children learn. Overall, we found that children acquired most pastoral skills and knowledge in early childhood, children were most likely to learn from parents (vertical transmission) and non-parental adults (oblique transmission), a relationship between age and specific modes of transmission did not exist, various forms of teaching were the most frequently mentioned processes of learning, and the frequency of teaching did not vary by the child’s age. When hunter-gatherer’s and pastoralist’s patterns of cultural learning were compared several similarities emerged: most accounts of learning occurred in early childhood, children were most likely to learn from parents and non-parental adults, and various forms of teaching were the most frequently mentioned processes of learning. Several differences in cultural learning between the two groups were identified: pastoralist ethnographers were less likely than hunter-gatherer ethnographers to mention learning from peers and more likely to mention learning via local enhancement and stimulus enhancement.
Retinal microvascular abnormalities, cotton wool-like lesions, and macular edema following COVID-19 in a patient previously vaccinated with AstraZeneca and idiopathic myopathy
Authors: Damasceno Nadyr A , Horowitz Soraya , Rezende Fernando , Yannuzzi Nicholas A , Farah Michel E , Flynn Harry , Damasceno Eduardo F
Published: October 2022

In this case study, the authors describe peculiar bilateral cotton wool-like retinal lesions associated with macular edema in a patient with COVID-19 who was vaccinated with a single dose of AstraZeneca one month earlier. This patient had no pulmonary or systemic cardiovascular complications from COVID-19, as reported in other papers that found retinal lesions. However, the patient was diagnosed with idiopathic myopathy when discovering the SARS-CoV-2 infection. The patient was a 22-year-old white female with no previous history of morbidity, complaining of blurred vision in both eyes seven days after testing positive for SARS-CoV-2 by PCR (using nasal and oral swab) and confirmed through ELISA blood test (IgM positive). There was no ancillary test revealing diabetes mellitus. The patient presented with scattered whitish cotton wool-like lesions and a few hemorrhages on the posterior pole in fundus examination. On spectral domain optical coherence tomography (SD-OCT), there were hyperreflective lesions in the nerve fiber layer, ganglion cell layer, inner nuclear layer, and inner and outer plexiform layers at the site corresponding to the whitish cotton wool-like lesions in the posterior fundus photos. Moreover, the macula of both eyes had intraretinal and subretinal fluid, reversible with corticosteroid therapy. In conclusion, COVID-19 has been associated with capillary disorders at different target sites such as retina, lungs, and central nervous system. Similarly, vaccination against SARS-CoV-2 has been linked to retinal complications in the literature; however, cotton wool-like lesions have not yet been reported. There are many questions yet to be answered about the implications of COVID-19 infection and its vaccines.
How Does Multi-Platform Social Media Use Lead to Biased News Engagement? Examining the Role of Counter-Attitudinal Incidental Exposure, Cognitive Elaboration, and Network Homogeneity
Authors: Guo Jing , Chen Hsuan-Ting
Published: October 2022

Using an online panel survey in the United States, this study examines how multi-platform social media use impacts news engagement on social media. Results show that multi-platform social media use prompts incidental exposure to counter-attitudinal news and further encourages people to cognitively elaborate on the counter-attitudinal information, which in turn contributes to news engagement on social media. However, news engagement is performed in a biased way that is supportive of like-minded content and non-supportive of counter-attitudinal content. Furthermore, the indirect effect of multi-platform social media use on biased news engagement becomes stronger when one’s network is more homogeneous. Although studies have pointed to the democratic prospects of multi-platform social media use as it leads to cross-cutting exposure, our results suggest that it could lead users to engage with news in ways that confirm their pre-existing attitudes and disconfirm counter-attitudinal ones.
NGS better discriminates true MRD positivity for the risk stratification of childhood ALL treated on an MRD-based protocol
Authors: Svaton Michael , Skotnicova Aneta , Reznickova Leona , Rennerova Andrea , Valova Tatana , Kotrova Michaela , van der Velden Vincent H. J. , Brüggemann Monika , Darzentas Nikos , Langerak Anton W. , Zuna Jan , Stary Jan , Trka Jan , Fronkova Eva
Published: October 2022

We compared minimal/measurable residual disease (MRD) levels evaluated by routinely used real-time quantitative polymerase chain reaction (qPCR) patient-specific assays and by next-generation sequencing (NGS) approach in 780 immunoglobulin (IG) and T-cell receptor (TR) markers in 432 children with B-cell precursor acute lymphoblastic leukemia treated on the AIEOP-BFM ALL 2009 protocol. Our aim was to compare the MRD-based risk stratification at the end of induction. The results were concordant in 639 of 780 (81.9%) of these markers; 37 of 780 (4.7%) markers were detected only by NGS. In 104 of 780 (13.3%) markers positive only by qPCR, a large fraction (23/104; 22.1%) was detected also by NGS, however, owing to the presence of identical IG/TR rearrangements in unrelated samples, we classified those as nonspecific/false-positive. Risk group stratification based on the MRD results by qPCR and NGS at the end of induction was concordant in 76% of the patients; 19% of the patients would be assigned to a lower risk group by NGS, largely owing to the elimination of false-positive qPCR results, and 5% of patients would be assigned to a higher risk group by NGS. NGS MRD is highly concordant with qPCR while providing more specific results and can be an alternative in the front line of MRD evaluation in forthcoming MRD-based protocols.
Reduction in vaso-occlusive events following stem cell transplantation in patients with sickle cell disease
Authors: Leonard Alexis , Furstenau Dana , Abraham Allistair , Darbari Deepika S. , Nickel Robert S. , Limerick Emily , Fitzhugh Courtney , Hsieh Matt , Tisdale John F.
Published: October 2022

Hematopoietic stem cell transplantation (HSCT) is potentially curative for patients with sickle cell disease (SCD). Patients with stable donor engraftment after allogeneic HSCT generally do not experience SCD-related complications; however, there are no published data specifically reporting the change in vaso-occlusive events (VOE) after HSCT. Data regarding the number of VOEs requiring medical attention in the 2 years before allogeneic HSCT were compared with the number of VOEs in the 2 years (0-12 months and 12-24 months) after allogeneic HSCT in patients with SCD. One-hundred sixty-three patients with SCD underwent allogeneic HSCT between 2005 and 2019. The average age at the time of HSCT was 21 years (range, 7 months – 64 years). Most patients underwent nonmyeloablative conditioning (75% [N = 123]) and had a matched sibling donor (72% [N = 118]). The mean number of VOEs was reduced from 5.6 (range, 0-52) in the 2 years before HSCT to 0.9 (range, 0-12) in the 2 years after HSCT (P < .001). Among the post-HSCT events, VOE was more frequent during the first 12 months (0.8 [range, 0-12]) than at 12 to 24 months after HSCT (0.1 [range, 0-8) (P < .001)). In patients who had graft rejection (12%, N = 20), VOEs were reduced from 6.6 (range, 0-24) before HSCT to 1.1 (range, 0-6) and 0.8 (range, 0-8) at 0 to 12 months and 12 to 24 months after HSCT, respectively (P < .001). VOEs requiring medical care were significantly reduced after allogeneic HSCT for patients with SCD. These data will inform the development of novel autologous HSCT gene therapy approaches.
Mechano-covalent protection of coagulation factor VIII by von Willebrand factor
Authors: Butera Diego , Wang Haoqing Jerry , Woon Heng-Giap , Zhao Yunduo Charles , Ju Lining Arnold , Hogg Philip J.
Published: October 2022

von Willebrand factor (VWF) is the protective carrier of procoagulant factor VIII (FVIII) in the shear forces of the circulation, prolonging its half-life and delivering it to the developing thrombus. Using force spectroscopy, VWF-FVIII complex formation is characterized by catch-bond behavior in which force first decelerates then accelerates bond dissociation. Patients with mutations in VWF at the FVIII binding site phenocopies hemophilia A and the most common mutations are of cysteine residues involving multiple disulfide bonds. From differential cysteine alkylation and mass spectrometry experiments, 13 VWF disulfide bonds at the FVIII binding site were found to exist in formed and unformed states, and binding of FVIII results in partial formation of 12 of the VWF bonds. Force spectroscopy studies indicate that the VWF-FVIII bond stiffens in response to force and this feature of the interaction is ablated when VWF disulfide bonds are prevented from forming, resulting in slip-only bond behavior. Exposure of VWF to pathological fluid shear forces ex vivo and in vivo causes partial cleavage of all 13 disulfide bonds, further supporting their malleable nature. These findings demonstrate that FVIII binding to VWF involves dynamic changes in the covalent states of several VWF disulfides that are required for productive interaction in physiological shear forces.
DeepMPM: a mortality risk prediction model using longitudinal EHR data
Authors: Yang Fan , Zhang Jian , Chen Wanyi , Lai Yongxuan , Wang Ying , Zou Quan
Published: October 2022

Background

Accurate precision approaches have far not been developed for modeling mortality risk in intensive care unit (ICU) patients. Conventional mortality risk prediction methods can hardly extract the information in longitudinal electronic medical records (EHRs) effectively, since they simply aggregate the heterogeneous variables in EHRs, ignoring the complex relationship and interactions between variables and the time dependence in longitudinal records. Recently deep learning approaches have been widely used in modeling longitudinal EHR data. However, most existing deep learning-based risk prediction approaches only use the information of a single disease, neglecting the interactions between multiple diseases and different conditions.

Results

In this paper, we address this unmet need by leveraging disease and treatment information in EHRs to develop a mortality risk prediction model based on deep learning (DeepMPM). DeepMPM utilizes a two-level attention mechanism, i.e. visit-level and variable-level attention, to derive the representation of patient risk status from patient’s multiple longitudinal medical records. Benefiting from using EHR of patients with multiple diseases and different conditions, DeepMPM can achieve state-of-the-art performances in mortality risk prediction.

Conclusions

Experiment results on MIMIC III database demonstrates that with the disease and treatment information DeepMPM can achieve a good performance in terms of Area Under ROC Curve (0.85). Moreover, DeepMPM can successfully model the complex interactions between diseases to achieve better representation learning of disease and treatment than other deep learning approaches, so as to improve the accuracy of mortality prediction. A case study also shows that DeepMPM offers the potential to provide users with insights into feature correlation in data as well as model behavior for each prediction.
Histological and molecular responses of Vigna angularis to Uromyces vignae infection
Authors: Ke Xiwang , Wang Jie , Xu Xiaodan , Guo Yongxia , Zuo Yuhu , Yin Lihua
Published: October 2022

Background

To advance the understanding of adzuki bean (Vigna angularis) resistance to infection with the rust-causing fungus Uromyces vignae (Uv), we comprehensively analyzed histological events and the transcriptome of Uv-infected adzuki bean.

Results

Compared with the susceptible cv. Baoqinghong (BQH), the resistant cv. QH1 showed inhibition of uredospore germination and substomatal vesicle development, intense autofluorescence of cells around the infection site, and cell wall deposit formation in response to Uv infection. In cv. QH1, gene set enrichment analysis (GSEA) showed enrichment of chitin catabolic processes and responses to biotic stimuli at 24 h post-inoculation (hpi) and cell wall modification and structural constituent of cytoskeleton at 48 hpi. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis indicated enrichment of WRKY transcription factors (TFs), the calcium binding protein cml, and hydroquinone glucosyltransferase at both 24 and 48 hpi. In total, 1992 and 557 differentially expressed genes (DEGs) were identified at 24 and 48 hpi, respectively. Cell surface pattern-recognition receptors (PRRs), WRKY TFs, defense-associated pathogenesis-related (PR) proteins, and lignin and antimicrobial phenolic compound biosynthesis were significantly induced. Finally, we detected the chitinase (CHI) and phenylalanine ammonia-lyase (PAL) activity were higher in QH1 and increased much earlier than in BQH.

Conclusion

In cv. QH1, cell-surface PRRs rapidly recognize Uv invasion and activate the corresponding TFs to increase the transcription of defense-related genes and corresponding enzymatic activities to prevent fungal development and spread in host tissues.
The effectiveness of case management for cancer patients: an umbrella review
Authors: Wang Nina , Chen Jia , Chen Wenjun , Shi Zhengkun , Yang Huaping , Liu Peng , Wei Xiao , Dong Xiangling , Wang Chen , Mao Ling , Li Xianhong
Published: October 2022

Background

Case management (CM) is widely utilized to improve health outcomes of cancer patients, enhance their experience of health care, and reduce the cost of care. While numbers of systematic reviews are available on the effectiveness of CM for cancer patients, they often arrive at discordant conclusions that may confuse or mislead the future case management development for cancer patients and relevant policy making. We aimed to summarize the existing systematic reviews on the effectiveness of CM in health-related outcomes and health care utilization outcomes for cancer patient care, and highlight the consistent and contradictory findings.

Methods

An umbrella review was conducted followed the Joanna Briggs Institute (JBI) Umbrella Review methodology. We searched MEDLINE (Ovid), EMBASE (Ovid), PsycINFO, CINAHL, and Scopus for reviews published up to July 8th, 2022. Quality of each review was appraised with the JBI Critical Appraisal Checklist for Systematic Reviews and Research Syntheses. A narrative synthesis was performed, the corrected covered area was calculated as a measure of overlap for the primary studies in each review. The results were reported followed the Preferred reporting items for overviews of systematic reviews checklist.

Results

Eight systematic reviews were included. Average quality of the reviews was high. Overall, primary studies had a slight overlap across the eight reviews (corrected covered area = 4.5%). No universal tools were used to measure the effect of CM on each outcome. Summarized results revealed that CM were more likely to improve symptom management, cognitive function, hospital (re)admission, treatment received compliance, and provision of timely treatment for cancer patients. Overall equivocal effect was reported on cancer patients’ quality of life, self-efficacy, survivor status, and satisfaction. Rare significant effect was reported on cost and length of stay.

Conclusions

CM showed mixed effects in cancer patient care. Future research should use standard guidelines to clearly describe details of CM intervention and its implementation. More primary studies are needed using high-quality well-powered designs to provide solid evidence on the effectiveness of CM. Case managers should consider applying validated and reliable tools to evaluate effect of CM in multifaced outcomes of cancer patient care.
Health services supervision in a protracted crisis: a qualitative study into supportive supervision practices in South Sudan
Authors: Lutwama George William , Sartison Lodi Joseph , Yugi James Onyango , Nehemiah Taban Nickson , Gwang Zechreya Micheal , Kibos Barbara Akita , Jacobs Eelco
Published: October 2022

Background

The health system in South Sudan faces extreme domestic resource constraints, low capacity, and protracted humanitarian crises. Supportive supervision is believed to improve the quality of health care and service delivery by compensating for flaws in health workforce management. This study aimed to explore the current supervision practices in South Sudan and identify areas for quality improvement.

Methods

The study employed qualitative approaches to collect and analyse data from six purposefully selected counties. Data were collected from 194 participants using semi-structured interviews (43 health managers) and focus group discussions (151 health workers). Thematic content analysis was used to yield an in-depth understanding of the supervision practices in the health sector.

Results

The study found that integrated supportive supervision and monitoring visits were the main approaches used for health services supervision in South Sudan. Supportive supervision focused more on health system administration and less on clinical matters. Although fragmented, supportive supervision was carried out quarterly, while monitoring visits were either conducted monthly or ad hoc. Prioritization for supportive supervision was mainly data driven. Paper-based checklists were the most commonly used supervision tools. Many supervisors had no formal training on supportive supervision and only learned on the job. The health workers received on-site verbal feedback and, most times, on-the-job training sessions through coaching and mentorship. Action plans developed during supervision were inadequately followed up due to insufficient funding. Insecurity, poor road networks, lack of competent health managers, poor coordination, and lack of adequate means of transport were some of the challenges experienced during supervision. The presumed outcomes of supportive supervision were improvements in human resource management, drug management, health data reporting, teamwork, and staff respect for one another.

Conclusion

Supportive supervision remains a daunting task in the South Sudan health sector due to a combination of external and health system factors. Our study findings suggest that strengthening the processes and providing inputs for supervision should be prioritized if quality improvement is to be attained. This necessitates stronger stewardship from the Ministry of Health, integration of different supervision practices, investment in the capacity of the health workforce, and health infrastructure development.
Advances in the modulation of ROS and transdermal administration for anti-psoriatic nanotherapies
Authors: Xu Jiangmei , Chen Hao , Qian Haisheng , Wang Fei , Xu Yunsheng
Published: October 2022

Reactive oxygen species (ROS) at supraphysiological concentration have a determinate role in contributing to immuno-metabolic disorders in the epithelial immune microenvironment (EIME) of psoriatic lesions. With an exclusive focus on the gene-oxidative stress environment interaction in the EIME, a comprehensive strategy based on ROS-regulating nanomedicines is greatly anticipated to become the mainstay of anti-psoriasis treatment. This potential therapeutic modality could inhibit the acceleration of psoriasis via remodeling the redox equilibrium and reshaping the EIME. Herein, we present a marked overview of the current progress in the pathomechanisms of psoriasis, with particular concerns on the potential pathogenic role of ROS, which significantly dysregulates redox metabolism of keratinocytes (KCs) and skin-resident or -infiltrating cells. Meanwhile, the emergence of versatile nanomaterial-guided evolution for transdermal drug delivery has been attractive for the percutaneous administration of antipsoriatic therapies in recent years. We emphasize the underlying molecular mechanism of ROS-based nanoreactors for improved therapeutic outcomes against psoriasis and summarize up-to-date progress relating to the advantages and limitations of nanotherapeutic application for transdermal administration, as well as update an insight into potential future directions for nanotherapies in ROS-related skin diseases.

Graphical Abstract
Feasibility of Large-Scale Implementation of an Electronic Patient-Reported Outcome Remote Monitoring System for Patients on Active Treatment at a Community Cancer Center
Authors: Cherny Nathan I. , Parrinello Christina M. , Kwiatkowsky Lavi , Hunnicutt Jeff , Beck Thaddeus , Schaefer Eric , Thurow Tracy , Kolodziej Michael
Published: October 2022

PURPOSE:

The use of digital symptom monitoring with patient-reported outcomes (PROs) has been shown to improve patient outcomes. The evidence of benefit has been largely derived from research studies. The feasibility of adopting this technology in the real-world setting is unknown.

METHODS:

We report on the clinical implementation of a proprietary electronic patient-reported outcome (ePRO)–based digital symptom monitoring platform at the Highlands Oncology Group practice, a large community oncology practice. We present here our experience with patient enrollment, engagement, and retention; reasons for discontinued use; proportion of reports generating alerts and containing severe symptoms; and the responses to alerts including nursing telephone consultations and urgent office visits.

RESULTS:

Over an approximately 17-month period, 923 patients were successfully enrolled. Patients enrolled from June 20, 2020, through November 30, 2021, with follow-up through February 28, 2022. Retention rates at 3, 6, 9, and 12 months were 94%, 88%, 73%, and 67%, respectively, with greater retention at 12 months in patients age 65 years or older. Few patients discontinued use for reasons related to the platform (n = 47; 5%). Of the 25,311 ePRO reports submitted, 49% (n = 12,334) exceeded the predefined alert thresholds and 8% (n = 1,920) included severe symptoms. The nursing team responded within 24 hours by telephone to 31.2% (n = 3,910) of all reports with alerts. Of reports with severe symptoms, 72.7% (n = 1,395) received a call. Only 6.4% (n = 249) of phone calls required an office evaluation within 72 hours of the report.

CONCLUSION:

This single-center experience indicates that an ePRO-based digital symptom monitoring platform can be effectively implemented at a large scale with a high level of long-term patient engagement. Most reports could be effectively resolved by nurses, and physician intervention was infrequently required.
High-Dose Methotrexate in Patients With Lymphoma: Predictors of a Complicated Course
Authors: O'Donoghue Darragh F. , Truong Huong L. , Finnes Heidi D. , McDonald Jennifer S. , May Heather P. , Ansell Stephen M. , Bennani N. Nora , Habermann Thomas M. , Inwards David J. , Johnston Patrick B. , Khurana Arushi , Lin Yi , Micallef Ivana N. , Nowakowski Grzegorz S. , Paludo Jonas , Porrata Luis F. , Thanarajasingam Gita , Thompson Carrie A. , Villasboas Jose C. , Wang Yucai , Witzig Thomas E. , Leung Nelson
Published: October 2022

PURPOSE:

High-dose methotrexate (HDMTX; > 500 mg/m2) is an important component of lymphoma therapy. Serum MTX monitoring at 48 hours is the standard approach to identify those at increased risk of developing MTX toxicity. Our aim was to characterize the incidence of complications and their association with MTX levels.

METHODS:

A retrospective review of our institutional electronic medical record was conducted to identify patients with lymphoma who received HDMTX between January 1, 2002, and December 31, 2018. We characterized the incidence of acute kidney injury (AKI), intensive care unit (ICU) admission, length of hospital stay (LOS), and 30-day mortality across 48-hour MTX levels. To establish an association between 48-hour MTX levels and the complications listed, we performed chi-square analysis for dichotomous variables and Kruskal-Wallis for nonparametric data. Receiver operator characteristic curve analysis was performed to identify the MTX level where AKI grade ≥ 2 was more likely. Multivariate logistic regression analysis was performed to identify risk factors for this MTX level.

RESULTS:

We identified 642 patients with 2,804 cycles of HDMTX. The incidence of AKI was 19.1% with AKI grade ≥ 2 making up 21% of cases. Rates of AKI, ICU admission, and 30-day mortality are associated with elevated 48-hour MTX levels. There was a significant increase in median LOS with elevated MTX levels ( P < .001). Receiver operator characteristic curve analysis for AKI grade ≥ 2 demonstrated a 48-hour MTX level threshold of 1.28 μmol/L. Multivariate logistic regression analysis revealed age, male sex, elevated body surface area, higher MTX dose, monotherapy, and first cycle as independent factors.

CONCLUSION:

Elevated MTX levels are associated with a significant increased rate of AKI, ICU admission, prolonged LOS, and 30-day mortality. Elevated 48-hour MTX levels, particularly > 1.28 μmol/L, should alert clinicians for complications and to initiate measures to reduce MTX levels.
Geniculate Neuralgia: A Case Report and Systematic Review
Authors: Tatit Rafael Trindade , Raffa Paulo Eduardo Albuquerque Zito , Seba Maria Clara Cardoso , Franceschini Paulo Roberto , de Aguiar Paulo Henrique Pires
Published: October 2022

BACKGROUND AND IMPORTANCE:

Geniculate neuralgia (GN) is a rare disorder characterized by brief paroxysms of pain felt deeply in the auditory canal, like shock. The diagnosis of GN is essentially clinical and requiring the exclusion of other causes. The aim of this study was to report a case of surgical treatment of the disease and perform a systematic review of surgical treatment options.

CLINICAL PRESENTATION:

A 62-year-old female patient has had severe, sharp pain in her left ear—like an ice pick—for the past 8 months, without any history of trauma or infection. She had triggers for pain, such as talking or swallowing. Imaging investigation showed a vessel touching VIIth and VIIIth nerves, possibly the anterior inferior cerebellar artery. After finding a clinical presentation compatible with GN, treatment with anticonvulsants, gabapentinoids, and opioids was attempted, but without success with such conservative treatments. Therefore, we opted for microvascular decompression and section of the nervus intermedius, which were performed without complications. Neurophysiological assessment was essential to monitor the long tracts and stimulate VIIth and VIIIth nerves to help identify the intermediate nerve. After the procedure, the patient was without pain, and after 12 months of follow-up, she remains without any pain.

CONCLUSION:

Surgical treatment of GN might be beneficial when medical treatment has not worked. Cranial nerves neurophysiological monitoring is not routinely performed, and the identification is based on anatomy. A more comprehensive knowledge of this condition will help in the surgical treatment choice and in achieving better results.
The Impact of Extended Lean Manufacturing Principles on the Economic Efficiency of Industrial Companies
Authors: Gan'kin N.
Published: October 2022

The main purpose of this study is an analytical proof of the effect of the extended principles of lean manufacturing of economic products on the economic efficiency of industrial companies. To achieve this goal, the following tasks were performed: the tendency to increase the share of value-added operations was investigated, the analysis of existing cost accounting methods was carried out, it was proposed to consider the cost structure depending on the type of operation.

The object of research is modern industrial enterprises using the concept of lean manufacturing and its analogues. The subject of the study is the effect of the extended principles of lean manufacturing in the creation of economic products.

Methods of abstraction and comparative analysis were used to study the impact of the extended principles of lean manufacturing. In addition, methods of analysis and synthesis were used to study the existing methods of cost accounting. The historical method was also used in the work to analyze stable trends in the development of industry.

Based on empirical data, there is a tendency to increase the share of operations that add value to the final product. It was found that non-value-added operations account for 84% of the cost of an economic product, which confirms the need to apply the expanded concept of lean manufacturing in modern realities, as it will significantly reduce this share by eliminating material and especially information losses. As a result of the study of existing methods of cost accounting, it is proposed to consider the cost of any economic product structurally consisting of material and information components for operations that add and do not add value to the final product.

As a result of the conducted research, the influence of the expanded principles lean manufacturing of economic products on the economic efficiency of modern industrial enterprises was analytically proved and the expediency of applying the proposed concept of lean manufacturing was confirmed.
Formation of the Concept of «Learning-by-Doing» in Production
Authors: Kondratyev Dmitriy
Published: October 2022

The article discusses the formation of economic views on such a phenomenon as the learning-by-doing effect. This concept, which appeared in the 30s of the last century, does not lose its relevance today. So this concept can become an effective planning tool, which makes it possible to apply it in practice in the economy of a company. The areas of application of this concept in the activities of the company are also given in the article. The work is based on the analysis of publications of foreign and national authors who have made a significant contribution to the development of the theory of learning-by-doing, the impact of accumulated experience on the economic growth of the company. In particular, the model of the learning curve of T. Wright, the experience curve of B. Henderson, endogenous models of economic growth by K.J. Arrow, P. Romer, E. Sheshinsky, L.E. Varshavsky. The practical significance of this work lies in the formation of the basis for further research in this subject area. The results of the work can form the basis for formation the learning model for one of the modern national industries.
Perception of basic values, factors and structures socio-historical development of Russia (based on research and testing materials)
Authors: Harichev A. , Shutov A. , Polosin A. , Sokolova E.
Published: October 2022

The article analyzes the results of the study of emotional-imaginative vision of the basic factors and structures that affect the current state of development of the Russian state, acting as stabilizing, unifying and motivating social vectors. Taking into account the breadth of the study, its processed results make it possible to increase the effectiveness of developing national strategies in the field of civil society formation based on a common understanding of basic constructive values that are as consonant with the personal worldview of a particular citizen as possible. There is also the prospect of creating a full-fledged integral "national code" formed from intuitive archetypes and images that reinforce the traditional strengths of Russian society, which can be described as a hierarchical system of interrelated images and meanings. The study was conducted on the basis of materials from brainstorming sessions in the period from March 4 to May 20, 2022, the method was tested to describe worldview systems in groups of MSU and HSE students, the teaching staff of the conference participants in Sevastopol.
Pemanfataan Teknologi Tepat Guna Mesin Balistik Pencacah Sampah untuk Sistem Pengolahan Sampah Organik pada TPS Bangsal sebagai Salah Satu Sumber Keuangan BumDes Desa Bangsal, Mojokerto
Authors: Rusdiyana Liza , Suhariyanto Suhariyanto , Sampurno Bambang , Sanyoto Budi Luwar , Mashuri Mashuri , Hakim M. Lukman
Published: October 2022

Penduduk berkontribusi terhadap besarnya timbulan 17.498.160 kg/hari sampah dengan asumsi komposisi sampah organik 60% dan sampah plastik 14%. Hal ini juga terjadi pada masyarakat desa Bangsal Mojokerto. Masyarakat belum mengolah sampah dengan benar, sehingga BUMDes Bangsal berinisiatif mengelola sampah warga. BUMDes Bangsal juga menerima sampah dari desa tetangga yaitu desa Puloniti, Sumberwono, Sidomulyo dan Pacing. Pada kenyataannya, yang paling banyak menumpuk dan tak terolah adalah sampah organik, dimana sebenarnya dapat dimanfaatkan salah satunya untuk menghasilkan pupuk organik/ kompos yang berguna untuk perkembangbiakan dan kesuburan tanaman. Dari hasil tinjauan, pembuatan kompos masih banyak dilakukan secara manual terutama proses pencacahan sampah organik. Pencacahan adalah salah satu proses yang penting, sampah yang dicacah menjadi lebih kecil (0,55–25mm) bentuknya sehingga mempermudah decomposing sehingga mikrobakteri pengurai bekerja secara maksimal. Hasil abdimas dengan pemberian Mesin Balistik ini, sampah organik yang ada di TPS Bangsal berhasil dikelola menjadi kompos hingga 70%. Hasil olahannya dikembalikan ke penduduk desa untuk pertanian masyarakat setempat dimana salah satunya kompos ini diberikan kepada ibu-ibu PKK yang menggerakkan pertanian skala rumah tangga, sehingga pertanian mereka mampu menjadi penopang kebutuhan pangan untuk keluarga. Adapun BUMDes selaku pengelola TPS berharap bisa menjadikan hasil olahan kompos ini dikemudian hari dapat menjadi salah satu pemasukan BUMDes.
Pembuatan Water Bike untuk Mendukung Wisata Air di Ecowisata Waduk Tempuran Blora
Authors: Pitana Trika , Santoso Agoes , Cahyono Beny , Iswantoro Adhi , Siswantoro Nurhadi , Nugroho Dwi Oktavianto Wahyu
Published: October 2022

Waduk Tempuran merupakan salah satu waduk yang terletak di Kabupaten Blora, Jawa Tengah. Peran daripada waduk ini sangat penting terutama untuk pengairan lahan pertanian di sekitar wilayah Kecamatan Blora sejak jaman sebelum Indonesia merdeka. Selain itu, manfaat lain dari waduk ini adalah sebagai salah satu wisata andalan di Kabupaten Blora. Dengan anugerah kondisi alam dan geografis yang indah, tentu ini menjadi daya tarik untuk wisatawan. Wisata yang selama ini sudah ada di Waduk Tempuran adalah wisata air seperti perahu naga, perahu dayung kano dan wisata kuliner berupa ikan bakar Waduk Tempuran serta wisata petik buah. Khusus untuk wisata air, masih sangat bisa dikembangkan lagi sehingga lebih menarik, salah satunya adalah dengan adanya sepeda air atau water bike. Dengan adanya sepeda air ini maka akan semakin banyak pilihan wisata air bagi wisatawan untuk menikmati keindahan Waduk Tempuran. Harapannya pembuatan sepeda air ini menjadi edukasi kepada pengunjung untuk tetap berolahraga dan menjadi pemicu warga sekitar untuk membuat sepeda air dengan desain yang lain.
Supporting attendance in early years
Authors: Cowley Sue
Published: October 2022

Attendance has been a key focus for the DfE for a number of years, with policies emphasising regular attendance at school, and a new ‘live attendance’ tracker being trialled. However, with the EYFS being mainly a non-compulsory phase of education, attendance rules differ to those for school-aged pupils. Sue Cowley explores what this means for settings, looking at how they can work with parents and carers to encourage good attendance.
Inspiring practice through block play
Authors: Postles Kate
Published: October 2022

This second article in the series titled ‘leadership journey’, looks at Kate as a pedagogical leader, with the focus of inspiring practice improvements through block play and beyond.
To sell or not to sell? – letting your early years baby go
Authors: Wright David
Published: October 2022

Are you interested in the process behind selling an early years setting? In this article David Wright shares with us this insight, as well as personal experience of selling Paint Pots Nurseries.
Gender in play
Authors: Martin Maryanne
Published: October 2022

Play is an essential part of a child's growth and development. It is also a great way for children to develop their socialisation and communication skills, and helps them understand themselves and explore their gender. This is the third article in a series that explores children's experiences of gender.
Leading by example
Authors: Celinska Angelica
Published: October 2022

Amy Purt, who is currently a nursery manager and Level 4 early years advanced practitioner, is undergoing a BA Hons Early Childhood Studies degree, and tells us how passionate she is about training and continuous professional development. Amy discusses leading by example, and this is certainly clear when it comes to continuous progression of knowledge and skills! It is also fantastic to read how well supported Amy felt throughout her journey in the early years from some brilliant staff teams and leaders, it is evident that this has really supported the love for early years and lifelong learning that Amy radiates!
Supporting children and families with SEND
Authors: Ghiara Virginia , Liverpool Shaun
Published: October 2022

This opinion piece looks at ‘the right support’ for children with special educational needs and disabilities, and what this support looks like for them and their families. A valuable tool is offered which is the new Spotlight Set from the Early Intervention Foundation, providing information on 28 evidence-based interventions that are available to support children and young people with recognised or possible SEND as well as their carers.
Urinary tract infections in children: A guide for primary care nurses
Authors: Perry Margaret
Published: October 2022

Margaret Perry explains what nurses need to know when children present with this common condition
Impaired wound healing in diabetes
Authors: Swoboda Laura , Held Jessica
Published: October 2022

Impaired wound healing for patients with diabetes is due to a constellation of structural, biochemical, cellular and microbial factors. Hyperglycaemia and its associated inflammation contribute to immune dysfunction, vascular damage, neuropathy, cellular senescence, impaired transition beyond the inflammatory stage, microbiome disruptions, failed extracellular matrix formation, growth factor and cytokine imbalance, limited re-epithelialisation, and alterations in fibroblast migration and proliferation. Optimising glycaemic control remains the primary intervention to prevent continual dysfunction and comorbid disease progression.
Sinister Schooling: Modern-Day Implications of Hampton Model Industrial Schools and American Indian Boarding Schools
Authors: Hunt Brittany
Published: October 2022

Throughout American history, the government has taken various systemic measures to monitor, surveil and control its burgeoning minority populations. In the postbellum era, these aims were primarily focused on assimilation and cultural genocide modeled, beginning with the creation of schools like the Hampton Model Schools for Black students and American Indian boarding schools for Indigenous students. Though neither remain in operation, their spirit lives, particularly as we see Native and Black students being funneled into occupational tracks in high school, having disproportionately high rates of suspension and expulsion, and being subjected to a whitewashed curriculum that positions them as victims, criminals, or non-existent. This work seeks to explore the linkages between these historical institutions and the current status of Native and Black students in modern-day schools.
How the consumption of green public spaces contributes to quality of life: evidence from four Asian cities
Authors: Di Giulio Antonietta , Sahakian Marlyne , Anantharaman Manisha , Saloma Czarina , Khanna Rupali , Narasimalu Srikanth , Zhang Dunfu
Published: October 2022

While green public spaces have been studied in relation to biodiversity and climate change, and in relation to health and social inclusion, there is a need to further understand how they relate to a broader understanding of human wellbeing. Evidence suggests that public spaces play an important role with a view to happiness and mental health, but further evidence is needed on how people actually use such spaces and how human needs are met – and how this might compare across different contexts. This necessitates to linking conceptually, empirically and practically the consumption of such spaces, the notion of the good life, and the management of such spaces. Towards this aim, this article explores quality of life in relation to green public spaces in four cities of South and Southeast Asia: Chennai, Metro Manila, Shanghai and Singapore. Based on empirical research in these cities, we engage in a comparative analysis to discuss how and in what way ‘going to the park’ as a form of consumption is a satisfier towards meeting ‘Protected Needs’ (Di Giulio and Defila, 2020) such as to live in a livable environment, to develop as a person or to be part of a community. The analysis shows that the practice ‘going to the park’ is linked to the practice ‘making the park’, leading to a discussion on how public policies can further support quality of life in cities. On a theoretical note, the article contributes to the debate about how to conceptually link human needs and social practices.
Two-photon polymerization for random rough surface preparation
Authors: Lindner Benjamin , Glöckler Felix , Kienle Alwin
Published: October 2022

A typical tool to characterize diffuse materials is the determination of the scattering and absorption coefficients. Most of these evaluation methods consider optically smooth surfaces between the investigated and the surrounding medium. However, realistic surfaces generally show a distinct roughness, which influences the reflected and transmitted light of the investigated material. Hence, it is necessary to understand the optical behavior of these rough surfaces. We present a method for the preparation of such optically rough surfaces using two-photon polymerization. The properties of these rough surfaces can be precisely adjusted within a range of a few hundred nanometers. Additionally, an easy-to-use preparation method is shown to compensate for reflections from the backside of the used substrate. Hence, these surfaces can be used for measuring the reflectance leading to a better understanding of the scattering behavior of rough surfaces and their influence on the determination of the optical properties of turbid media.
Ultra-high-Q resonances in terahertz all-silicon metasurfaces based on bound states in the continuum
Authors: Wang Pengfei , He Fengyan , Liu Jianjun , Shu Fangzhou , Fang Bin , Lang Tingting , Jing Xufeng , Hong Zhi
Published: October 2022

High-Q metasurfaces have important applications in high-sensitivity sensing, low-threshold lasers, and nonlinear optics due to the strong local electromagnetic field enhancements. Although ultra-high-Q resonances of bound states in the continuum (BIC) metasurfaces have been rapidly developed in the optical regime, it is still a challenging task in the terahertz band for long years because of absorption loss of dielectric materials, design, and fabrication of nanostructures, and the need for high-signal-to-noise ratio and high-resolution spectral measurements. Here, a polarization-insensitive quasi-BIC resonance with a high-Q factor of 1049 in a terahertz all-silicon metasurface is experimentally achieved, exceeding the current highest record by 3 times of magnitude. And by using this ultra-high-Q metasurface, a terahertz intensity modulation with very low optical pump power is demonstrated. The proposed all-silicon metasurface can pave the way for the research and development of high-Q terahertz metasurfaces.