bluuebunny/crossref_metadata_2025 huggingface dataset:
α-GLUCOSIDASE INHIBITORY ACTIVITY AND FORMULATION OF SOLID LIPID NANOPARTICLE CONTAINING ETHANOL 70% STANDARDIZED EXTRACT OF KUMIS KUCING LEAVES (Orthosiphon stamineus Benth.)
Authors: Tambunan Risma Marisi , Juliyanti Winda Dwi
Published: August 2019

Kumis kucing leaves (Orthosiphon stamineus Benth.) are one type of plants that is able to inhibit the activity of α-glucosidase enzyme. This study aims to formulate Solid Lipid Nanoparticle from ethanol 70% standardized extract of kumis kucing leaves and which give α-glucosidase enzyme inhibitory activity. The result of SLN characteristic for particle size of formula I, II and III shows the result of 51,60 nm; 12.81 nm; 11.87 nm and zeta potential of formula I, II and III show the results -27.67; -10,7; -15.0, respectively. The results of the α-glucosidase enzyme inhibitory activity of the standardized extract, SLN formula I, II and III respectively showed IC50 of 132.9 ppm; 130.3 ppm; 131.4 ppm; 132.2 ppm and Acarbose as comparison showed IC50 of 50.0 ppm. Data processing using t-test statistically at α = 0,05 showed that extract and SLN of formula I had significant difference, thus the best SLN formula was formula I with concentration of tween 80 and propylenglycol of 6% and 10%.
DEVELOPMENT AND VALIDATION OF A QUESTIONNAIRE TO IDENTIFY FACTORS ATTRIBUTE TO THE BEHAVIOR OF NON-PRESCRIPTION ANTIBIOTIC USED
Authors: Setiawan Eko , Djawaria Dewi Paskalia Andi , Prayitno Adji
Published: August 2019

Factors attributing to the behavior of non-prescription used of antibiotics in Indonesia setting have not been identified yet. The availability of effective and efficient instrument or method to identify the attributing factors might be the cause of non-optimal identifying process. The objective of present study was to develop instrument, i.e questionnaire, to identify factors contributing to the behavior of non-prescription used of antibiotics. The questionnaire was developed based on factors identified on published scientific literatures. Face and content validity were conducted by having the experts’ judgement, while the construct validity was conducted by using the Spearman Correlation Test. Reliability was tested by using Cronbach’s alpha test. There were 14 rating and 8 multiple answer questions in the questionnaire that could be classified unto 5 domains. After conducting the validity and reliability test, the final questionnaire had a R value 0.276-0.628 and Cronbach’s alpha 0.833. This valid and reliable questionnaire could be used to portray the attributing factors of non-prescription used of antibiotics in larger area, therefore, the most appropriate intervention could be planeed based on the identified factors.
Activity of Antibiotic Bacterial Isolate Kp13 and Cell Leakage Analysis of Escherichia coli Bacteria
Authors: Syarifuddin Alfian , Sulistyani Nanik , Kintoko Kintoko
Published: August 2019

A bacterium is one of microorganisms that can produce secondary metabolite, such as antibiotic. KP13 isolate is a bacterium isolated from Melaleucaleuca dendron L rhizosphere. The aim of this study is to know the eff ect of the most active fraction antibacterium of KP13 isolate toward Escherichia coli bacterium and the ability to caused cell leakage. Extraction of antibiotic was conducted by ethyl acetate. Extract is fractioned with a n-heksan-etilacetate solvent gradient another uses a solvent methanol. Each fraction is done by KLT and grouped based on RF value. A fraction group is compare by inhibition eff ectiveness. Then, the Minimum Inhibitory Concentration (MIC) from the most active group is tested. Cell leakage analysis was performed using UV spectrophotometry to detect the release of nucleic acid and protein. Atomic Absorption Spectrophotometry (AAS) was used to detect ion release of K+ and Ca2+ from. cell of bacteria. The results showed that the most active fraction against Escherichia coli was the fraction number 1 with MIC value of 5% and inhibition zone of 7.33±0.58 mm.
The Effect of Rosella (Hibiscuss sabdariff a L.) Powder on CD4 Counts in Healthy Volunteers
Authors: Mardhiyani Dini , Darmawan Endang , Akrom Akrom
Published: August 2019

Roselle flower (Hibiscus sabdariffa L.) is beneficial as an immunostimulant because of its antioxidant property. Antioxidants in roselle flower are hibiscus anthocyanin, quercetin, L-ascorbic acid and protocatechuic acid. Any potential plants for pytopharmacy should be proven beneficial and safe through preclinical and clinical trial. The purpose of this clinical trial was to determine the effect of ethanol extract of roselle (Hibiscus sabdariffa L.) to lymphocyte and CD4 cell count in healthy volunteer for 30 days.

This study used pre-post treatment design. A total of 21 healthy volunteer were chosen according to inclusion and exclusion criteria and filled informed consent. Healthy volunteer were given 500 mg roselle ethanol extract powder every day for 30 days. Lymphocyte and CD4 cell count was conducted using hematology analyzer and flowcytometer. Results were analyzed using paired t test, if the distribution is not normal than Wilcoxon test will be used on 95% confidence interval.

Results showed that there was no significant effect (p>0,05) of CD4 cell absolute count and there was a significant effect of CD4 percentage (p<0,05). Results on day 45 (14 days after the treatment was interrupted) showed no significant effect (p>0,05) of CD4 cell absolute count and CD4 cell percentage. The effect of CD4 cell percentage on day 31 was in normal range.

This study concluded that 500 mg roselle petal ethanol extract powder (Hibiscus sabdariffa L.) given everyday for 30 days showed some effect on d increasing CD4 cell percentage.
Efek Anti Diabetes Spirulina Platensis Terhadap Analisis Kadar, Gambaran Histopatologi, Ekspresi Insulin dan Glucose Transpoter 4 Pada Tikus Putih Wistar yang Diinduksi Streptozopin
Authors: Kintoko Kintoko , Balfas Rifqi Ferry , Ustrina Nura , Widyarini Sitarina , Saputri Lintang Cahya , Nurwijayanti Anandita , Riana Fajar Slamet , Anggraini Neni Tri
Published: August 2019

Berdasarkan Riset Kesehatan Dasar, di Yogyakarta angka kejadian diabetes melitus berdasarkan diagnosis dokter didapat sebanyak  2,6% dan gejala akan meningkat sesuai bertambahnya umur, namun akan turun mulai umur >65 tahun. Pada pengobatan diabetes melitus ini terdapat beberapa pengobatan dengan obat sintetik dan bahan alam untuk bahan alam salah satunya yaitu Spirulina platensis. Spirulina platensis adalah salah satu mikroalga yang di dalamnya mengandung spektrum alami dari campuran karoten dan pigmen xantofil, dan dengan fikosianin memiliki aktivitas antioksidan, serta Spirulina platensis dapat menunjukan penurunan pada gula darah.

Jenis penelitian yang dilakukan merupakan penelitian eksperimental. Spirulina platensis dibuat suspensi dengan beberapa macam dosis 36 mg, 72 mg, dan 144 mg. Tikus dibagi 6 kelompok, 5 kelompok diinduksi streptozotosin dengan dosis 45 mg/kgBB hingga tikus mengalami DM ditandai dengan hasil KGD yang tinggi, kemudian di beri suspensi spirulina, di ukur kadar gula pada hari ke 0-28. Setelah itu tikus di ambil darah kemudian dianalisis pengaruh Spirulina platensis terhadap kadar kreatinin dan ureum dalam darah. Hasil dianalisis menggunakan SPSS metode ANOVA dan Post Hoc Test dengan taraf kepercayaan 95%.

Hasil dari analisis kadar pada berbagai kelompok menunjukan bahwa pada induksi streptozotocin yang diberi perlakuan spirulina plantesis berbagai dosis terdapat perbaikan pada tiap analisis kadar yang didapat, dan juga pada dosis STZ+SP 36 pada tiap analisis dapat memperbaiki kadar analisis. Sedangkan pada hasil histopatologi serta ekspresi insulin pada pankreas dan histologi serta ekspresi glucose transporter 4 serta histopatologi pada ginjal dan hati menunjukan perubahan yang baik pada berbagai kelompok dosis perlakuan terutama pada kelompok STZ+SP 36. Sehingga pada dosis STZ+SP 36 yang menunjukan perubahan yang baik pada penelitian ini.
The Role of Medicine Pricing Policy for Improving the Affordability of Medicines
Authors: Anggriani Yusi
Published: August 2019

Medicine is a pharmaceutical product that has imperfect market characteristics. This affects affordability to the community, and therefore it is necessary for the government to regulate medicine prices. Medicine prices can be regulated in the medicine supply chain by the industry, importers, distributors and health facilities such as pharmacies, hospitals and medicine sellers. Developed and high income countries generally regulate the prices of medicines and are part of a health insurance system. In contrast with the situation in developed countries, medicine pricing regulation in developing countries and Lower Middle Income Countries is not well established. The regulation of mark-ups in distribution channels is the most common strategy used by LMIC. Small country with only a few pharmaceutical facilities has a weak bargaining position, generally the government cannot set prices. The application of cost-plus pricing is quite effective if it is implemented in a small country. In developing countries with a large market segment and adequate pharmaceutical industry facilities the price competition method is an effective strategy option to get lower prices. In practice, the application of  medicine pricing policy is dynamic. The medicine pricing system in a country can be changed or combined with other methods if the evaluation does not provide optimal results or generates unintended impacts.
Analgesic and Anti-Inflammatory Activities of Eurycoma longifolia root in Mice
Authors: Hendra Phebe , Susana Wina , Permatasari Indriyani , Florensia Jessy , Siregar Monita Natalia
Published: August 2019

This study was conducted to evaluate the analgesic and anti-inflammatory acitvities of Eurycoma longifolia root in mice. The analgesic effect was assessed using chemical stimuli (wrihting test) to induce peripheral pain in mice. The anti-inflammatory activity was determined using carrageenan-induced paw edema in mice. This study exhibites that Eurycoma longifolia root possesses analgesic and anti-inflammatory activities in mice.
CREATIVITY BASED TOURISM IN KAMPUNG KREATIF DAGO POJOK BANDUNG
Authors: Agung Wisesa Kresna , Adhi Gunadi I Made , P. Mbulu Yustisia
Published: August 2019

In this current era, many villages in Indonesia carry the concept of Tourism Village. One of them is a creative village located in Dago Pojok Bandung, West Java. This study aims to find out about tourism products and identify how the application of creativity based tourism in the Dago Pojok creative village. Data collection is done by descriptive qualitative method with observation and interview techniques. The variables used are the concept of tourism products consisting of tourist attractions and activities, accommodation facilities and services, other facilities and services (supporting facilities), transportation facilities and services, infrastructure and other institutions, and the concept of creativity based tourism consisting of local artists, ideas/knowledge and interaction. Based on the results and discussion, it can be concluded that tourism products in Dago Pojok creative village are tourism products based on culture, creativity, and art. Dago Pojok creative village is a tourism that is based on creativity, because the elements of Local Artisan, Idea or Knowledge, and Interaction have fulfilled the requirements in implementing tourism with the concept of creativity, but there are some thingsthat need to be improved, namely in the part of interaction it hasn't been carried out optimally.
PEMILIHAN KAWASAN WISATA KULINER SEBAGAI DAYA TARIK WISATA DI KOTA BOGOR
Authors: Mutiara Clara , Firmansyah Riza
Published: August 2019

Bogor Barat Culinary Area is a culinary area with the most restaurants in the cityof Bogor. It can be known that currently there are approximately 65 restaurants in North Bogor. This area is quite strategic and islocated on the trade route that has been planned by the Bogor City Government, this is the big opportunity for North Bogor Region as the biggestculinary area in th ecity of Bogor. In this study the concept of culinary tourism was used to analyze several restaurants with the concept of culinary tourism seen from the Menu, Food Production Strategy, Service, Price and Room Decor / Atmosphere by taking a sample of 10 restaurants in North Bogor, including : Ayam Geprek Istimewa, Bakso Misterius, Bumi Aki, Foresthree Resto, Gurih 7, Lemongrass Resto, Teras Dara, Whatever Resto dan Warung Urban.The purpose of this study is to analyze the existing conditions of culinary tourism in North Bogor and analyze the selection of restaurants in North Bogor. The design of this study uses a descriptive approach with qualitative methods. For the selection of culinary tourism area, it uses AHP analysis to find out which culinary tourism concept is more desirable and what restaurant is the priority. To find out the development strategy of North Bogor culinary area with a SWOT analysis.
STRATEGI PENGEMBANGAN KAMPUNG 99 PEPOHONAN SEBAGAI DAYA TARIK WISATA EDUKASI DI KOTA DEPOK
Authors: Darmawan Jody , Nurhidayati Hindun
Published: August 2019

Educational tour or educational tour is a program that combines elements of tourism activities with the content of informal education in it. This program is packaged in such a way to be an annual tourism activity or extracurricular activities that have quality and weight for participants who follow this educational tour, the material to be used in this tour has been adjusted to the weight of participants and what information will be provided. village 99 Trees is one of the objects of educational-based tourism destination that provides tourism activities in the area of forest conservation and nature. The objective of the study was to identify the educational potential of Village 99 area and to develop education development strategy in village 99 area. The method used in this research is qualitative method, data collection with observation, questionnaire and documentation. Data analysis in this study using SWOT analysis.The result of the research is SO's strategy which involves involving local communities in the development of educational tourism. Establishing cooperation with gold dome managers related to tourist management, Maintaining beautiful environmental conditions to keep cool, making group tour packages using fish objects.
Language Utterance Among India Community In Padang
Authors: Farisya Fajrina Putri
Published: August 2019

This thesis title is Language Utterance Among India Community in Padang
The writer focusing on the language that utter among India community in Padang. The India people usual talk and communication with other with mix language which another did not know. The writer seek this as uniqueness that can be describe by code mixing theory and sociolinguistik.
            The writer uses sociological theory for reach the purposes of the research. Purposes of the research is to descirbe the language change that happen in India community in Padang.. language change that happens have relate with linguistic theories. After getting the data, the writer , makes formula from the code mixing that utter in India community in Padang. This research uses field research method for get the significant data and library research for get the theories that will be uses as basic theory in this thesis. Technique collecting of data is qualitative method, which the writer get the data from 7 qualified interviewee based on criteria ( NORM (Nonmobile Older Rural Males). From it, the writer uses record technique for get the data.
            The results from the research that has been done, the wrier finds language change that influence  by another ethnic such Minang, Tionghoa Padang and Indonesia. The changing are, vowel /i/ change into /e/ in medial, disappearance /h/ in final,initial and medial. Disappearance /r/ in final and medial, absorption /at/ become /?/ in final,absorption /u/ become /o/ in medial and final, absorption /t/ become /k/ in final, absorption  /a/ into /o/ in final, absorption /p/ into /?/, absorption/ŋ/ into /aŋ/ in final, absorption /e/ become /a/ in medial and initial. Disappearance /e/ in medial, disappearance /d/ in initial, and medial,also disappearance /p/ in final. Code mixing that utter by India community that has been describe by code mixing theory, and become a formula from it.
Morphofonemical Verba In Kerinci Language
Authors: Fitrianti Eva
Published: August 2019

Research on the morphophonemic process of Kerinci language verb is done with the background of many linguistic problems that have not received attention in Kerinci language and very little documentation has been done to the language of Kerinci. This research is done with awareness of the effort to conserve one of the elements of culture, namely language. This research is a qualitative research with descriptive method, which aims to describe Kerinci language empirically based on the situation or facts that exist in the field and presented with what it is. The informant is a native speaker of Kerinci. Data collection techniques used are recording techniques, elasticity techniques, and techniques refer.
Data analysis technique used in this research is transcribing data into writing language, translating data into Indonesian, and analyzing data. To facilitate the analysis, the data already written and translated into Indonesian language is then classified by word category. The result of this research is that there are four rules of morphophonemic process of verb forming affix, ie {maN-}, {N-}, {bar-}, and {ta-}. The four rules of verb-forming merbophonemic in Kerinci, can be classified again into two processes: phoneme change and phoneme removal processes.
Idioms of Mentawai Language Inmuntei Village
Authors: Aditiawarman Mac , Sakukuret Agustinus
Published: August 2019

This thesis is about the idioms of Mentawai language in Muntei Village. Idiom is a word or phrase whose meaning is not obvious through knowledge of individual meanings of the constituent words but must be learnt as a whole. Idiom is something that has its own meaning and we cannot guess the meaning because it needs to be learnt to understand their meaning.  The writer took the data from the elder in the community by doing an interview with the informant (a man) whose age is no more than 50 years old to make sure that the informant still remembers the right word of the idioms. Technique of collecting the data of this analysis is by doing the interview to the informant first, and then writes the data down in a table accordingly to their forms.
In analyzing this data, the writer uses three theories from three experts. In order to analyze the forms of the idioms used by people in Muntei Village the writer uses the theory of idioms forms from Yayat Sudaryat. In order to analyze the syntactical functions of the idioms used by people in Muntei Village the writer uses the theory of syntactical functions of idioms from Jennifer Seidl and McMordie. Meanwhile for analyzing the meaning of the idioms, the writer uses the theory of idioms meaning from Aminuddin. The result shows that there are two forms of idioms that commonly found in Muntei Village, they are the full idioms (formed in sentence) and half idioms (formed in words or phrases). The result also shows that idioms have this syntactical function that make then can be placed as the subject, object, adjectives, and adverbs in the sentence. This research also shows that the meaning of the idioms that usually found in Muntei Village can only be understood by the people if they know who are the people involved in the conversation, what is the situation where the conversation occur, and what is the intention of using the idioms.
Influence of Marketing Statements Found in Women’s Cosmetic Products to Their Mindset in Determining the Definition of Beauty
Authors: Astuti Amelia Yuli , Oktisyafyeni Febi
Published: August 2019

This journal discusses about the influence of the marketing statements found in women’s cosmetic products to their mindset in determining the definition of beauty. The writer takes the data from the marketing statements that happened in the commercial advertisements of four most used and commonly shown in audio visual media, such as television, which are Pond’s, Citra, Shinzui, and Garnier. The Technique of collecting the data of this thesis is the observation technique which then continued by writing down the conversatios that includes the marketing statements of the commercial advertisements into a form of a transcription. The writer uses the speech-act theory by John Langshaw Austin to analyze the influence of the marketing statements which presented through the conversations in the commercial advertisements, the theory of signs by Charles William Morris to analyze the signs that showed up in the commercial advertisements, and the theory of meaning by Charles Kay Ogden and Ivor Amstrong Richards to analyze the meaning of the symbols of signs that showed up in both the conversations and the narration. The result of this study shows that in every part of those products commercial advertisements, the marketing statements always try to influence the women to believe that indeed having white/bright/light skin means beautiful.
The Hubble Space Telescope PanCET Program: Exospheric Mg ii and Fe ii in the Near-ultraviolet Transmission Spectrum of WASP-121b Using Jitter Decorrelation
Authors: Sing David K. , Lavvas Panayotis , Ballester Gilda E. , Lecavelier des Etangs Alain , Marley Mark S. , Nikolov Nikolay , Ben-Jaffel Lotfi , Bourrier Vincent , Buchhave Lars A. , Deming Drake L. , Ehrenreich David , Mikal-Evans Thomas , Kataria Tiffany , Lewis Nikole K. , López-Morales Mercedes , García Muñoz Antonio , Henry Gregory W. , Sanz-Forcada Jorge , Spake Jessica J. , Wakeford Hannah R. ,   (The PanCET collaboration)
Published: August 2019

We present Hubble Space Telescope (HST) near-ultraviolet (NUV) transits of the hot Jupiter WASP-121b, acquired as part of the PanCET program. Time-series spectra during two transit events were used to measure the transmission spectra between 2280 and 3070 Å at a resolution of 30,000. Using HST data from 61 Space Telescope Imaging Spectrograph visits, we show that data from HST’s Pointing Control System can be used to decorrelate the instrument systematic errors (jitter decorrelation), which we used to fit the WASP-121b light curves. The NUV spectra show very strong absorption features, with the NUV white light curve found to be larger than the average optical and near-infrared value at 6σ confidence. We identify and spectrally resolve absorption from the Mg ii doublet in the planetary exosphere at a 5.9σ confidence level. The Mg ii doublet is observed to reach altitudes of R
pl/R
star = 0.284 ± 0.037 for the 2796 Å line and 0.242 ± 0.0431 for the 2804 Å line, which exceeds the Roche lobe size as viewed in transit geometry (R
eqRL/R
star = 0.158). We also detect and resolve strong features of the Fe ii UV1 and UV2 multiplets, and observe the lines reaching altitudes of R
pl/R
star ≈ 0.3. At these high altitudes, the atmospheric Mg ii and Fe ii gas is not gravitationally bound to the planet, and these ionized species may be hydrodynamically escaping or could be magnetically confined. Refractory Mg and Fe atoms at high altitudes also indicate that these species are not trapped into condensate clouds at depth, which places constraints on the deep interior temperature.
Pattern of Impact-induced Ejecta from Granular Targets with Large Inclusions
Authors: Kadono Toshihiko , Suetsugu Ryo , Arakawa Dai , Kasagi Yoshiki , Nagayama Syuichi , Suzuki Ayako I. , Hasegawa Sunao
Published: August 2019

We performed impact experiments to observe patterns in an ejecta curtain with targets consisting of small sand particles and large inclusions comparable to or smaller than the size of the projectiles. The spatial intensity distributions in the ejecta at early stages of crater formation depend on the size of the inclusions. Our numerical simulations of radially spreading particles with different sizes support this result. Based on the results, we proposed a procedure for evaluating the subsurface structures of celestial bodies from the images of ejecta curtains obtained from space-impact experiments.
Record-breaking Coronal Magnetic Field in Solar Active Region 12673
Authors: Anfinogentov Sergey A. , Stupishin Alexey G. , Mysh’yakov Ivan I. , Fleishman Gregory D.
Published: August 2019

The strongest magnetic fields on the Sun are routinely detected at dark sunspots. The magnitude of the field is typically about 3000 G, with only a few exceptions that reported the magnetic field in excess of 5000 G. Given that the magnetic field decreases with height in the solar atmosphere, no coronal magnetic field above ∼2000 G has ever been reported. Here, we present imaging microwave observations of anomalously strong magnetic field of about 4000 G at the base of the corona in solar active region NOAA 12673 on 2017 September 6. Combining the photospheric vector measurements of the magnetic field and the coronal probing, we created and validated a nonlinear force-free field coronal model, with which we quantify the record-breaking coronal magnetic field at various coronal heights.
Response of carabid and arachnid assemblages on plant invasion in woodlots within an agricultural landscape
Authors: Štrobl Martin , Saska Pavel , Seidl Miroslav , Řezáč Milan , Knapp Michal , Kadlec Tomáš
Published: August 2019

Landscape simplification and the spread of invasive species are considered the main threats to global biodiversity. It is well recognized that non-crop habitats bring complexity to farmland and provide refuge for arthropods. However, knowledge about the effects of invasive trees on arthropods in non-crop habitats in intensive agricultural landscapes is still weak. Therefore, we examined differences in the carabid and arachnid assemblages between woodlots formed by the invasive black locust (Robinia pseudoacacia L.) and by native deciduous tree species in the intensive agricultural landscape in the Czech Republic, Central Europe. We sampled carabids, harvestmen and spiders by using pitfall traps, sweeping the vegetation and light trapping. Effects of woodlot’s habitat structure, land cover composition in the surroundings and the area of woodlots were included to the analyses. The abundance of carabids was lower in R. pseudoacacia woodlots. Carabid individuals could benefit from the more favourable microclimate in the native woodlots, in which relatively greater humidity may support more ample food resources. On the contrary, species richness of carabids did not differ between the woodlot types. The abundance and species richness of arachnids did not differ between the woodlot types. Number of individuals increased with increasing woodlot’s area and the species richness increased with the more open woodlot’s habitat structure. The forest specialists of both groups were associated with the native woodlots with more developed canopy and shrub layers. The diversity losses of the arachnid forest specialists in the R. pseudoacacia woodlots were replaced by the species exploiting well-developed herb layer, and open-habitat specialists, including threatened species. Conversely, carabids of open habitats had no affinity to woodlot types. Native woodlots and those formed by R. pseudoacacia differed in vegetation structure and hosted different arachnid and carabid assemblages. Therefore, parallel presence of both types of woodlots supports arthropod diversity in otherwise simplified agricultural landscapes through creating more complex mosaic of habitats.
Longterm, Real-world Safety of Adalimumab in Rheumatoid Arthritis: Analysis of a Prospective US-based Registry
Authors: Harrold Leslie R. , Griffith Jenny , Zueger Patrick , Litman Heather J. , Gershenson Bernice , Islam Syed S. , Barr Christine J. , Guo Dianlin , Fay Jonathan , Greenberg Jeffrey D.
Published: August 2019

Objective.

To assess longterm safety in a US cohort of patients with rheumatoid arthritis (RA) treated with adalimumab (ADA) in real-world clinical care settings.

Methods.

This observational study analyzed the longterm incidence of safety outcomes among patients with RA initiating ADA, using data from the Corrona RA registry. Patients were adults (≥ 18 yrs) who initiated ADA treatment between January 2008 and June 2017, and who had at least 1 followup visit.

Results.

In total, 2798 ADA initiators were available for analysis, with a mean age of 54.5 years, 77% female, and mean disease duration of 8.3 years. Nearly half (48%) were biologic-naive, and 9% were using prednisone ≥ 10 mg at ADA initiation. The incidence rates per 100 person-years for serious infections, congestive heart failure requiring hospitalization, malignancy (excluding nonmelanoma skin cancer), and all-cause mortality were 1.86, 0.15, 0.64, and 0.33, respectively. The incidence of serious infections was higher in the first year of therapy (3.44, 95% CI 2.45–4.84) than in subsequent years, while other measured adverse effects did not vary substantially by duration of exposure. The median time to ADA discontinuation was 11 months, while the median time to first serious infection among those experiencing a serious infection event was 12 months.

Conclusion.

Analysis of longterm data from this prospective real-world registry demonstrated a safety profile consistent with previous studies in patients with RA. This analysis did not identify any new safety signals associated with ADA treatment and provides guidance for physicians prescribing ADA for extended periods.
Au bord du « centre » ou le regard éloigné
Authors: Poret-Petrucci Eugénie
Published: August 2019

En institution pour personnes handicapées mentales adultes, un regard éloigné permet de repérer les incohérences, les exercices de pouvoirs qui se jouent entre résidents et professionnels. Qui pourrait rendre l’autre fou ?
Bonneuil : cinquante ans après
Authors: Leroy Delphine
Published: August 2019

Après cinquante ans d’existence, qu’en est-il de l’école expérimentale de Bonneuil ? Créée en 1969 par Maud Mannoni, en réaction à l’accompagnement des enfants malades de cette époque, c’est-à‑dire à l’enfermement, l’isolement et la ségrégation, quelle place occupe aujourd’hui ce lieu dans le champ de la pédopsychiatrie à l’ère de l’inclusion pour tous, des tsa (troubles du spectre autistique) et des techniques comportementales ? Après un retour sur la mise en place de cette école et ses évolutions dans le temps, en lien avec les transformations législatives, nous verrons que l’école de Bonneuil reste un lieu pour vivre pour des enfants qui ne peuvent se supporter dans le système scolaire et éducatif traditionnel. Nous allons tenter de montrer comment l’école expérimentale de Bonneuil demeure pour ces enfants, et leur famille, un lieu vivant.
Mourir vivant : de l’institution du désir
Authors: Cabassut Jacques
Published: August 2019

Les procédures, démarches qualité et autres mises au pas managériales produisent un effacement du sujet du Désir et du Jouir, tant chez le professionnel que chez le patient, le résident, l’usager, voire… le client. L’Autre scène, celle de l’inconscient de l’institution, invisible et toujours en négatif, bien qu’active, n’est plus considérée : on ne traite plus des passions humaines qui composent son malaise, animent et façonnent le vivre ensemble du sujet de l’individuel comme de celui du collectif. Le désir (du soignant), les mouvements (d’amour, de haine) de transfert, la jouissance (sadomasochiste) persistent pourtant à déterminer les trois métiers impossibles freudiens du soigner, de l’éduquer, du gouverner. Et si la restauration du désir éthique ou d’une éthique du désir était le gage essentiel d’une institution vivante ?
La participation serait-elle une pratique contre-nature ?
Authors: Lebœuf Emeline
Published: August 2019

Décréter « faire participer » n’est pas suffisant. Pour être effective, la participation doit se provoquer. Cependant, il existe différentes manières de faire participer. Comment, dans le secteur médico-social, peut-on ajuster les pratiques des professionnels et des directions afin de mettre en œuvre « la participation » en donnant un réel pouvoir d’agir aux personnes accompagnées ?
L’analyse des pratiques professionnelles : garde-fou d’un secteur menacé
Authors: Gauthier Agnès
Published: August 2019

Directrice d’un sessad , l’auteure expose ici des arguments en faveur de l’analyse des pratiques, mais aussi le cadre de fonctionnement et les menaces qui pèsent sur cette modalité de travail. Dans un contexte où les cadres actuels restreignent le champ de pensée et d’action, dirigés par l’efficacité et la rentabilité, l’espace de l’analyse des pratiques est peut-être le seul espace encore vierge : un lieu où on peut encore parler de l’humain.
« Ici, je ne suis pas à ma place »
Authors: Berton Jacques
Published: August 2019

Trouver une place dans un dispositif de formation n’est pas qu’une affaire de stratégies relationnelles. Cette place renvoie également à des enjeux sociaux qui rapprochent « lutte des places » et « lutte des classes ». Dans cet article, très empreint de sociologie clinique, Géraldine, une étudiante en formation d’éducatrice spécialisée, vient faire écho à l’œuvre d’Annie Ernaux pour qui le « savoir » n’est pas innocent, c’est une pratique particulière qui n’affranchit pas notre regard des contradictions sociales.
Consommation de substances psychoactives à Mayotte
Authors: Delaye Malika , Soilihi Mouelevou Layla
Published: August 2019

Les substances psychoactives traditionnelles sont utilisées depuis longtemps à Mayotte. Associées pour la plupart à des remèdes, elles sont tolérées dans beaucoup de familles, voire consommées régulièrement. Les adolescents, en recherche de modèles, oscillent entre l’identification à leurs aînés et à des modèles opposés. Le contexte postcolonial génère cette opposition entre la culture traditionnelle locale et la culture occidentale. Cela se traduit dans les consommations de substances psychoactives.
Project-Based Learning Model Practicality on Local Network Devices Installation Subject
Authors: Maulana Ilham Tri , Hary Restyaliza , Purwasih Ratih , Firdian Fadil , Sundara Tri A , Na'am Jufriadif
Published: August 2019

Abstract— The learning process in vocational high schools is the decisive factor for being able to give birth to vocational secondary education graduates that are in accordance with their competencies. The learning process will determine whether the learning goals will be achieved. This study aims to develop a project-based learning device on the subject of Local Network Devices Installation. The method used is the Instructional Development Institute (IDI) with processed data sourced from 2 teachers and 29 students. The result of this study is practical that a value of 77.87%. It is concluded that this model is very helpful in learning Local Network Device Installation and as a reference model for other subjects.
Pupils’ Opinions on an Educational Virtual Reality Game in Terms of Flow Experience
Authors: Akman Emrah , Çakır Recep
Published: August 2019

The purpose of the study is; to evaluate a game developed by using virtual reality technology in the teaching of fractions which is one of the most difficult topics in the fourth-grade mathematics curriculum, according to the opinions of pupils. An educational virtual reality game (Keşfet Kurtul) was developed for the study. Dur-ing the development of the game, the ideas of experts were utilized and flow theo-ry was taken into account. The educational virtual reality game was developed in the light of the flow theory. The research was carried out in a school in Samsun with 4th grade pupils. The game was evaluated by the pupils in terms of overall evaluation, challenge-skills balance, concentration on the task, clear goals, sense of control, action-awareness merging, loss of self-consciousness, transformation of time, unambiguous feedback and autotelic experience. As a result, the educa-tional virtual reality game Keşfet Kurtul is a digital learning environment that pu-pils enjoyed a lot. It has been determined that all tasks except the "radio" task, and in general the game itself, provide flow experience. It is proposed to redesign just one task of the game in terms of challenge-skills balance and clear goals. It's sug-gested that in experimental studies, different variables can be examined.
Design and Implementation of Computer Aided Physical Education Platform Based on Browser/Server Architecture
Authors: Zhao Zhen , Yang Jing
Published: August 2019

Based on the B/S mode network development technology, this paper studies the design and implementation of computer-aided physical education platform. According to requirement analysis of the platform, this study carries out the overall design and detailed design of the platform, compares and analyzes the teaching effects of computer-aided physical education platform and the traditional teaching method. The research results show that: the computer-aided physical education platform runs stably and realizes the expected design functions, it can enrich the teaching content, enhance students' initiative awareness, stimulate their interest in learning, effectively improve the teaching effect, and the paper confirms the feasibility and effectiveness of the system. This research provides a reference for the application of computer-aided physical education platform in physical education and has certain practical significance.
Análise da força de reação do solo da marcha de idosos sobre a influência da simulação de sobrepeso em diferentes velocidades
Authors: Favaro Susana Otília Vilas Bôas , Lara Jerusa Petróvna Resende , De Oliveira Ana Carolina , Beck Joice Katiane Mendes , Rodacki André Luiz Felix
Published: August 2019

O objetivo deste estudo foi avaliar as forças de reação do solo (FRS) em individuos jovens e idosos sob a influência do sobrepeso simulado em diferentes velocidades de marcha. Método: 30 participantes, 15 jovens jovens (JOV; 22,0±3,7 anos) e 15 idosos (IDS; 69,8±6,4 anos) caminharam em uma passarela com e sem carga adicional. A simulação do sobrepeso se deu através da adição de carga em um colete de cargas variáveis até alcançar o índice de massa corporal (IMC) de sobrepeso (JOV 25kg/m²; IDS 27kg/m). Os dados foram coletados através de uma plataforma de força (AMTI, OR6-7-2000). Resultados: A média de carga adicionada foi de 13,2±4,0 kg para JOV e 11,7±3,4 para IDS; O nível de significância foi de p≥0,05. Ao normalizar os dados pelo peso, IDS obtiveram menores picos de FRS em relação aos JOV em ambas as velocidades. Porém, o IDS foi maior que o JOV apenas no segundo pico da força vertical (Fz2) em velocidade rápida. Conclusões: O sobrepeso simulado de forma direta pode não ser capaz de promover mudanças significativas nas quantidades de descarga do peso corporal que pudesse influenciar nas FRS. Os resultados encontrados apontam para uma relação positiva das alteralções na FRS e o envelhecimento.
As representações sociais de bacharelandos sobre ser profissional de Educação Física
Authors: Triani Felipe Da Silva , Barros Glhevysson Dos Santos , Junior Carlos Alberto De Oliveira Magalhães , Telles Silvio De Cassio Costa
Published: August 2019

O presente estudo investigou sobre as representações sociais de estudantes de bacharel de uma faculdade privada localizada na zona oeste do município do Rio de Janeiro a respeito de ser professor de educação física. O objetivo dessa pesquisa foi identificar e discutir as representações sociais que estudantes do curso de bacharelado em educação física associam ao ser profissional de educação física. Participaram 51 alunos, sendo 18 do sexo feminino e 33 do masculino, com média de idade de 25,52 anos ± 4,7, do primeiro ao oitavo período, dos turnos matutino e vespertino de uma instituição privada localizada na Zona Oeste da cidade do Rio de Janeiro. Os resultados desvelaram que saúde, formação, valores profissionais e atividade física são as associações que compõem, possivelmente, o núcleo central das representações sociais destes acadêmicos. O estudo concluiu que o grupo possui representações sociais sobre o ser profissional de educação física que desconsidera a dimensão humanística da área, evidenciando um olhar hegemônico para a dimensão biológica da área.
Âmbitos de atuação profissional de egressos dos cursos de pós-graduação em educação física da UFSC
Authors: Milan Fabrício João , Pereira Marcos Paulo Vaz de Campos , Lacerda Elias Barbosa , Folle Alexandra , Do Nascimento Juarez Vieira , Farias Gelcemar Oliveira
Published: August 2019

O estudo objetivou analisar os cenários antecedente e atual de atuação profissional de egressos dos cursos de mestrado e de doutorado em Educação Física, da Universidade Federal de Santa Catarina, entre 2006 e 2013. No estudo descritivo, de fonte documental, foram consultados os currículos (Plataforma Lattes) de um total de 276 ingressantes. Antes de ingressarem no mestrado e no doutorado, a atuação profissional dos egressos concentrava-se nos ambientes não formais, ensino superior público e educação básica. Após a conclusão, predominou o ensino superior público e o privado. Conclui-se que o ensino superior é a primeira opção dos egressos, aumentando a competitividade pela busca da melhor qualificação. A realização de atividades de pesquisa e a atuação no terceiro setor também continuam marcantes.
Efeito agudo de diferentes ordens de execução dos exercícios no número máximo de repetições em protocolos realizados com diferentes durações das repetições
Authors: Gomes Mateus Camargo , De Lacerda Lucas Túlio , Diniz Rodrigo César Ribeiro , Dos Santos Igor Humberto Ferreira , Rodrigues Karine Silva , Lima Fernando Vitor
Published: August 2019

O objetivo do presente estudo foi investigar o efeito no número máximo de repetições (NMR), da ordem de execução de dois exercícios que envolvem a participação de musculatura em comum, o agachamento guiado e o flexor de joelhos, em duas durações das repetições. Participaram do estudo 16 voluntários do sexo masculino e treinados na musculação. Os protocolos foram realizados em duas ordens dos exercícios e durações das repetições (livre e 4s) no qual os voluntários realizaram o NMR em cada exercício em duas séries, intensidade de 60% de 1RM, pausa de 90 segundos entre séries e 180 segundos entre exercícios. Foram realizadas duas ANOVAs two-way com medidas repetidas para comparação do somatório do NMR e quando necessário aplicado o post hoc de Bonferroni. Na duração da repetição livre, ambos os exercícios apresentaram um NMR maior quando realizados como primeiro exercício do que quando foram realizados como segundo. Porém, com a duração da repetição de 4s não houve interação nem efeito principal dos fatores analisados. Portanto conclui-se que a duração da repetição é uma variável capaz de modificar os resultados encontrados pelas diferentes ordens.
Badminton: possibilidades de ensino aplicadas ao contexto da educação física escolar
Authors: Aburachid Layla Maria Campos , Da Silva Schelyne Ribas , Araújo Nayanne Dias , Greco Pablo Juan
Published: August 2019

A forma de ensinar esportes na educação física escolar tem se modificado ao longo das últimas décadas, mas no Brasil esta transformação pedagógica ainda é recente, com estudos de intervenção dessa natureza sendo publicados a partir de 1993, porém ainda utilizando métodos tradicionais. O estudo objetivou demonstrar que o badminton pode ser ensinado na prática via diferentes métodos de ensino e, além disso, apontar em que as atividades propostas distinguem-se quanto a frequência de ocorrência para cada método aplicado. A amostra foi composta por 48 escolares (15,1±0,64 anos) de ambos os sexos e três professores. Os escolares foram separados em três grupos de acordo com o método de ensino (Analítico, TGfU e Integrativo). Aplicou-se 17 sessões para prática do badminton em cada método supracitado. Os resultados de confiabilidade apontaram excelentes índices de concordância intra e inter-avaliadores, a análise descritiva da categorização das aulas e o teste qui-quadrado evidenciaram as peculiaridades de cada método. Conclui-se que a aplicação dos referidos métodos no contexto real de ensino-aprendizagem do badminton estimula e reforça a validade ecológica da pesquisa, uma vez que as práticas ocorreram durante as aulas de educação física.
Molecular Dynamics Simulation on Aqueous Solution of Calcium Carbonate System
Authors: Wang Da Fang , Meng Dongdong , Wang Feng Jun , Cui Xin Dong
Published: August 2019

Molecular dynamics simulation was used to investigate two models of aqueous solution ofcalcium carbonate system between 283K and 373K. The diffusion coefficients of water moleculesdemonstrated that both the electropositive surface (110) on Model-I and neutral surface (104) onModel-II showed interaction with the water molecules, and the surface (110) exhibited strongerelectrostatic interaction with water molecules than the latter, besides obvious anomaly appeared near343K on Model-I. On the other hand, surface (110) exhibited anomalous influences on Ca2+ andCO32- ions near 313K and 343K on Model-I, and only a broad anomaly on CO32- ions near 343K onModel-II. The binding energies between surface (110) / (104) and Ca2+ /CO32- ions demonstrated thatthe surface (104)were more favorable for the growth of the new crystal but weak for the diffusion.
Analysis of the Causes of Tube and Pipeline Blocking in Sulige Gas Field
Authors: Huang Hang Juan , Cui Xi , Zhang Yuan , Xu Jian , Ma Yun
Published: August 2019

A large number of blockage appeared in gas wells and pipeline appeared, which causedplugging, corrosion and the increasing of wellbore pressure difference, and seriously affect thenormal production of gas well of problems. In this paper, the water quality of produced water fromthe severe cases of single wells or pipeline water were analyzed, also include the composition ofblockage and core with the chemical volumetric method (CVM) , X-Ray Diffraction (XRD) and x-rayfluorescence (XFS) method. Meanwhile, the core powder was leached in simulated acid worksolution, and then the leaching solution was analyzed with CVM. The experimental results show thatThe produced water has high salinity, high contents of Ca2+, Ba2+ and Sr2+, low pH value, which leadto corrosion and scaling. The main components of the blockage are acid insoluble strontium sulfate(barium) scale or corrosion product or mixture of corrosion and CaCO3 scaling product. Ca2+, Ba2+and Sr2+ were easy to scale in wellbore or pipeline when they encountered other produced water fromdifferent formation. The Ca2+, Mg2+, Ba2+, Sr2+ and Fe 2+/3+ mainly derived from the dissolution offormation debris in formation water and working fluid (especially acidic working fluid) to reservoirrock, so the salinity of the produced water increased, and the trend of scaling and corrosion alsoincreased with the gas field development.