bluuebunny/crossref_metadata_2025 huggingface dataset:
Deep Learning Neural Network for Statistical Modeling of Compressive Strength in Seybaplaya Bank Rocks: A Multivariate Analysis Incorporating Water Content, Porosity, and Density Parameters
Authors: NAAL-PECH JOSE WILBER , PALEMON-ARCOS LEONARDO , EL HAMZAOUI YOUNESS
Published: January 2025

Predicting uniaxial compressive strength (UCS) in geologically complex regions often poses significant challenges due to heterogeneous rock properties and limited field data. This study develops a site-specific, Bayesian-regularized neural network model to estimate UCS from three key parameters—moisture content, interconnected porosity, and real density—and implements, for the first time, a dedicated graphical user interface (GUI) tailored to the Bayesian Regularization Backpropagation algorithm. By leveraging locally acquired data from Seybaplaya’s carbonate–clay formations, the model captures the inherent variability of these bank rocks more effectively than conventional regression techniques. The approach employs a multivariate feedforward architecture with three hidden layers (10–6–1 neurons), trained under Bayesian regularization in MATLAB’s (trainbr) environment. This regularization framework not only mitigates overfitting but also promotes a parsimonious representation by constraining excessively large weight magnitudes. Extensive experimentation on a dataset of 134 samples—partitioned into training, validation, and test subsets—reveals a substantial reduction in mean squared error (MSE) (from ~29,100 to 326) alongside a marked decrease in sum of squared parameters (from 197 to ~7.63). These results underscore the network’s capacity to capture nonlinear interactions among the input features while maintaining balanced generalization across unseen data. Despite not reaching the stringent MSE target (1×10⁻⁷), the final model demonstrates moderate-to-strong predictive performance and highlights the significance of site-specific data in refining UCS estimations. This pioneering GUI-driven methodology provides an adaptable template for geomechanical analyses in regions typified by lithological heterogeneity and underscores the broader value of machine learning–based approaches for rock mechanics.
Mapping the Evolution of IBD Treatment: A Bibliometric Study on Biologics and Small Molecules
Authors: Li Huibo , Wang Jia , Hu Yang , Liu Yang , Li Jun , Zhu Yi Zhun , Zhao Rongsheng
Published: January 2025

Objectives: To investigate recent research trends in biologics and small molecules for the treatment of inflammatory bowel disease (IBD), a bibliometric analysis was conducted on literature from the past decade. Methods: This cross-sectional study involved a bibliometric analysis of data retrieved from the Web of Science Core Collection (WoSCC) database to examine the evolution and thematic trends on biological agents and small molecular drugs for IBD conducted between January 1, 2014, and September 20, 2024. A total of 6,337 articles were analyzed for specific attributes, including publication year, journal, country/region, institution, author, references, and keywords. VOSviewer software was utilized to perform co-authorship, co-occurrence, co-citation, and network visualization analyses, and further discussions were conducted on significant sub-themes.Results: From 2014 to September 20, 2024, the annual number of global publications increased by 23%, from 442 to 544. The journal "Inflammatory Bowel Diseases" published the highest number of manuscripts (579 publications) and garnered the most citations (13,632 citations), followed by the "Journal of Crohn's & Colitis" (480 publications) and "Alimentary Pharmacology & Therapeutics" (250 publications). The United States emerged as the leading country in terms of productivity (1,943 publications, 66,320 citations), with the University of California, San Diego (291 publications, 23,017 citations) and the author Sandborn, Vermeire, Severine (180 publications, 10,383 citations) being the most prolific institution and author, respectively. The co-occurrence cluster analysis of the top 100 keywords resulted in the formation of six distinct clusters: (1) Disease, (2) Drug, (3) Surgery, (4) Therapeutic Drug Monitoring, (5) Mechanism Research, and (6) Others. Recent keywords such as biologics, vedolizumab, ustekinumab, tofacitinib, Janus kinase inhibitor, therapeutic drug monitoring, trough level, and pharmacodynamics highlight the emerging frontiers in IBD research. We have synthesized information on biologics and small molecules approved by the European Medicines Agency (EMA), the Food and Drug Administration (FDA), and regulatory bodies in China, focusing on therapeutic targets and the immunological mechanisms underlying these diseases. Further discussions are provided to aid researchers in identifying potential research subjects and directions. Conclusions: This study elucidates current trends, patterns of global collaboration, foundational knowledge, research hotspots, and emerging frontiers in the field of biologics and small molecules for IBD treatment. Current research hotspots include the management of therapeutic drug monitoring (TDM) and safety, as well as investigations into monotherapy or switch therapy.
Sexuality, Gender Identity, Romantic Relations and Intimacy Among Young Adults and Adolescents with Autism Spectrum Disorder: A Narrative Review of the Literature
Authors: Belluzzo Miriam , Giaquinto Veronica , De Alfieri Erica , Esposito Camilla , Amodeo Anna Lisa
Published: January 2025

Sexual health is a vital aspect of overall well-being, yet individuals with autism spectrum disorder (ASD) face significant stigma and discrimination, affecting self-esteem, relationships, and sexual expression. This review examined recent literature (2020–January 2024) on intimacy and sexuality among adolescents and young adults with ASD, incorporating 32 studies. Findings highlight poorer sexual health among autistic individuals compared to the general population, with difficulties in forming romantic relationships and navigating sexual interactions due to hypersensitivity. Autism is also linked to non-conforming gender identities and asexuality, exposing individuals to dual stigma within the LGBTQ+ community. Autism-related traits hinder sexual health knowledge, increasing risks of victimization, abuse, and sexually transmitted infections. Comprehensive sexual education and inclusive support are crucial to address these challenges and promote sexual well-being for autistic individuals.
An Experimental Study Of The Vortical Structures In Supersonic Steam Jet Impinged On To The Wall
Authors: Khan Afrasyab , Sanaullah Khairuddin , Taranenko Pavel Alexandrovich , Sinitsin Vladimir Vladimirovich , Bassir David , Shah Ajmal , Zafar Ahmed , Henry Rigit Andrew Ragai
Published: January 2025

This study presents an experimental investigation into the impingement of a supersonic steam jet onto a wall. Steam was injected through a supersonic nozzle at a varying total pressure of 1.5-3.0 bars, producing a supersonic steam jet at a pressure gradient of 0.5-2.0 bars. The whole fluid domain is comprised of two regions: the jet region and the region near the wall involving the impingement of the supersonic steam jet. Within this region, the transformation of primary vortices into secondary vortices occurs and these vortices expel outward in the radial direction after impingement. Measurements have shown the spreading of the normalized density of the vortical structures along the axial length within the region near the wall. However, the probability density function analysis has indicated that the vortical structures become denser within the impingement region. Whereas subsequent to an impingement of the steam jet onto the wall, along the radial direction, weak traces of their existence in the jet region may be attributed to the vorticity diffusion within the jet region.
Microstructural Investigation and Mechanical Characterization of β-Type Ti-15Mo-13Nb, Ti-15Mo-16Nb, and Ti-15Mo-19Nb Alloys After Heat Treatment
Authors: MARCON HULISSES BONETI , Barbedo Elioenai Levi , Silva Sá Kaio Ariel , Ferreira Lucas Moreira , Capellato Patrícia , Silva Gilbert
Published: January 2025

With increasing longevity in many countries, the demand for prostheses to replace damaged hard tissue is growing. In recent years, efforts have focused on developing new titanium (Ti) alloys with a lower Young’s modulus, closer to that of human bone (30 GPa), given the average cost of $32,933 for prosthesis replacement procedures. While such alloys already exist, metastable β-Ti alloys have drawn attention due to their excellent combination of good strength, biocompatibility, and the abundance of titanium in the Earth’s crust. A better understanding of their properties and behavior, such as structure and element interaction, could create more efficient and long-lasting materials. To address this demand, this study aims to develop Ti-15Mo-yNb alloys (13, 15, and 19 at%) through arc melting, heat treatment, forging, and quenching. The alloys were analyzed using XRD, SEM, EDS, and mechanical testing. The β-Ti and α”-Ti phases were found, with Vickers hardness values ranging from 290 HV to 392 HV and Young’s modulus between 66 GPa and 75 GPa. The results show that higher Nb content helps form the α”-Ti phase at grain boundaries and improves the mechanical properties of the β-Ti matrix alloys.
Optimizing Light Management in Bifacial Perovskite Solar Cells Using Silica Based Anti-Dust and Anti-Reflection Coatings for Harsh Environments
Authors: Thomas Kevin , Rahman Ahasanur , Khandakar Amith , Chelvanathan Puvaneswaran , Aissa Brahim , Hossain Mohammad Istiaque
Published: January 2025

In this work, we demonstrate an advanced light management strategy for bifacial perovskite solar cells by incorporating a silica-based anti-dust and anti-reflection (AR) coating. The silica layer provides dual functionality: enhancing optical efficiency through effective reflection suppression and protecting the solar cell surface from environmental contaminants, especially dust. The hydrophobic nature of the silica coating further prevents dust and particulate accumulation, supporting a self-cleaning mechanism that maintains cell transparency and performance over extended periods. The simulation results indicate that transitioning from a monofacial to a bifacial design with a silica layer on top has a considerable impact on PSC performance. The optimized bifacial structure demonstrates high-performance metrics, achieving a voltage of 1.35 V, a fill factor of 84.24 %, a current density (JSC) of 29.10 mA/cm², and a power conversion efficiency of 31.00 % when illuminated from the electron transport layer side. When illuminated from the hole transport layer side, the structure attains a PCE of 22.00 %, with a calculated bifaciality factor (BF) of 72.12 %, highlighting the potential through bifacial PSC design. Our findings reveal that the addition of the silica layer leads to a notable improvement in light harvesting efficiency.
Copper Mountain Mine Tailings Dam Safety Review Supplement
Authors: Brox Daniel
Published: January 2025

Copper Mountain Mine tailings dam slope stability research based on recommendations of the 2021 Tetra Tech Dam Safety Review, including computation of tailings dam factors of safety, satellite imagery, steady state and transient seepage analyses, assessment of internal erosion risk, and flow liquefaction hazard analysis.
Financial Market Effects on Cryptocurrency Volatility: Symmetric and Asymmetric Evidence from the USA and Japan
Authors: Alsulami Faizah Hameed , Raza Ali
Published: January 2025

This study is the first to scientifically investigate stock indexes and currency exchanges that affect crypto prices. The purpose is to distinguish between the USA-Japan stock markets and the currency market's short- and long-term effects on bitcoin and ethereum. Auto Regressive Distributed Lag (ARDL) is used to analyze weekly series from 1-1-2016 to 20-10-2024. An asymmetric error-checking framework employing non-linear ARDL statistical approach to study variables affecting bitcoin and ethereum prices. Bitcoin appear to have short- and long-term linear effects on the US-Japan stock markets. Euro, GBP, and USA-Japan stock markets exhibit short-term linear effects with ethereum. Ethereum linearly affects GBP. This research helps exchange brokers and crypto traders diversify their holdings, reduce stock index and currency exchange risk, and accurately predict bitcoin and ethereum price variations.
Smart Lighting Systems: State-of-the-Art in the Adoption of the EdgeML Computing Paradigm
Authors: Paolone Gaetanino , Paesani Romolo , Pilotti Francesco , Camplone Jacopo , Piazza Andrea , Di Felice Paolino
Published: January 2025

Lighting Systems (LSs) play a fundamental role in almost every aspect of human activities. Since the advent of light, both academia and industry are engaged in raising the quality of the service offered by these systems. The advent of Light Emitting Diode (LED) lighting represented a giant step forward for such systems in terms of light quality and energy saving. To further raise the quality of the services offered by LSs, increase the range of services they offer, while at the same time consolidating their reliability and security, we see the need to explore the contribution that can derive from the use of the Artificial Intelligence of Things (AIoT) emerging technology. This paper systematically reviews and compares the state-of-the-art about the impact of the AIoT in the smart LSs domain. The study reveals that the field is relatively new, in fact the first works date back to 2019. In addition to that, the review delves into recent research works focusing on the usage of Machine Learning (ML) algorithms in an Edge-Cloud-based computing architecture. Our findings reveal that this topic is almost unexplored. Finally, the survey sheds light on future research opportunities that can overcome the current gaps, with the final aim of guiding scholars and practitioners in advancing the field of smart LSs. The study is reported in full details, so it can be replicated.
Evolution of β-Lactam Antibiotic Resistance in Proteus Species: From Extended-Spectrum and Plasmid-Mediated AmpC β-Lactamases to Carbapenemases
Authors: Bedenić Branka , Pospišil Mladen , Nađ Marina , Bandić Pavlović Daniela
Published: January 2025

The management of infectious diseases has proven to be a daunting task for clinicians worldwide and the rapid development of antibiotic resistance among Gram-negative bacteria is making it even more challenging. The first-line therapy is empirical and it most often comprises β-lactam antibiotics. Among Gram-negative bacteria Proteus mirabilis, important community and hospital pathogen associated primarily with urinary tract and wound infection, holds a special place. This review’s aim was to collate and examine recent studies investigating resistance phenotypes and mechanisms of Proteus species and the global significance of its resistance evolution. P. mirabilis as the dominant pathogen develops resistance to expanded-spectrum cephalosporins (ESC) by producing extended-spectrum β-lactamases (ESBL) and plasmid-mediated AmpC β-lactamases (p-AmpC). β-lactamase-mediated resistance to carbapenems in Enterobacterales including Proteus spp. is mostly due to expression of carbapenemases of class A (KPC), class B (metallo-β-lactamases or MBLs of IMP, VIM or NDM series) or class D or carbapenem-hydrolyzing oxacillinases (CHDL). Previously, a dominant ESBL type in P. mirabilis was TEM-52, yet lately it has been replaced by CTX-M variants, particularly CTX-M-3 and CTX-M-65. ESC resistance can also be mediated by p-AmpC with CMY-16 as the dominant variant. Carbapenem resistance in Proteus spp. is a challenge due to its intrinsic resistance to colistin and tigecyclin. The first carbapenemases reported, belonged to class B, most frequently VIM-1 and NDM-5. In Europe, predominantly France and Belgium, a clonal lineage positive for OXA-23 CHD spread rapidly undetected, due to its low-level resistance to carbapenems. Amazing capacity of Proteus spp. to accumulate a plethora of various resistance traits leading to multidrug or extensively- drug- resistant phenotype.
Mitochondrial HMG-CoA Synthase Deficiency in Vietnamese Patients
Authors: Nguyen Khanh Ngoc , Dien Tran Minh , Can Thi Bich Ngoc , Thao Bui Phuong , Dang Thi Kim Giang , Nguyen Ngoc Lan , Tran Van Khanh , Nguyen Thuy Thu , Trang Tran Thi Quynh , Phuong Le Thi , Nguyen Phan Long , Tran Thinh Huy , Tu Nguyen Huu , Vu Chi Dung
Published: January 2025

Background: Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency (HMGCS2D) is a rare metabolic disorder that impairs the body's ability to produce ketone bodies and regulate energy metabolism. Diagnosing HMGCS2D is challenging because patients typically remain asymptomatic unless experiencing fasting or illness. Due to the absence of reliable biochemical markers, genetic testing has become the definitive method for diagnosing HMGCS2D. Methods: This study included 19 patients from 14 unrelated families diagnosed with HMGCS2D in our department between October 2018 and October 2024. The clinical presentations, biochemical findings, molecular characteristics, and management strategies were systematically summarized and analyzed. Results: Of the 19 cases studied, 16 were symptomatic and three were asymptomatic. The onset of the first acute episode occurred between 10 days and 28 months of age. Triggers for the initial crisis in the symptomatic cases included poor feeding (93.8%), vomiting (56.3%), diarrhea (25.0%), and fever (18.8%). Clinical manifestations during the first episode were lethargy/coma (81.3%), rapid breathing (68.8%), hepatomegaly (56.3%), shock (37.5%), and seizures (18.8%). Biochemical abnormalities observed included elevated plasma transaminases (100%), metabolic acidosis (75%), hypoglycemia (56.3%), and elevated plasma ammonia levels (31.3%). Additionally, low free carnitine levels were found in seven cases, elevated C2 levels in one case, dicarboxylic aciduria in two cases, and ketonuria in two cases. Abnormal brain MRI findings were detected in three patients. Genetic analysis revealed seven HMGCS2 gene variants across the 19 cases. Notably, a novel variant, c.407A>T (p.D136V), was identified and has not been reported in any existing databases. Two common variants, c.559+1G>A and c.1090T>A (p.F364I), were present in 11 out of 19 cases (57.9%) and 10 out of 19 cases (55.5%), respectively. Implementation of high glucose infusion and proactive management strategies—such as preventing prolonged fasting and providing enteral carbohydrate/glucose infusion during illness—effectively reduced the rate of acute relapses following accurate diagnosis. Currently, all 19 patients are alive, with ages ranging from five months to 14 years, and exhibit normal physical development. Conclusions: To the best of our knowledge, this study represents the first reported cases of HMGCS2D in Vietnamese patients. Our findings contribute to a broader understanding of the clinical phenotype and expand the known spectrum of HMGCS2 gene variants, enhancing current knowledge of this rare metabolic disorder.
Endometriosis in Adolescents: A Closer Look at Pain Characteristics and atypical symptoms. A prospective Cohort Study
Authors: Viscardi Maria Federica , Piacenti Ilaria , Musella Angela , Cacciamani Laura , Piccioni Maria Grazia , Manganaro Lucia , Muzii Ludovico , Porpora Maria Grazia
Published: January 2025

Background/Objectives: Endometriosis affects up to 10% of women of reproductive age and about 47% of adolescents with pelvic pain. Symptoms include dysmenorrhea, dyspareunia, and chronic pelvic pain (CPP). Adolescents often present atypical symptoms which can make endometriosis more difficult to diagnose. This study aimed to compare characteristics of pain, atypical symptoms, and the effects of hormonal treatments between adolescents and adults with endometriosis. Methods: A total of 238 women with endometriosis were included: 92 aged 12–18 (group A) and 146 over 18 (group B). Data on menarches, cycle length, comorbidities, dysmenorrhea, dyspareunia, CPP, analgesic use, pain characteristics, atypical symptoms, and endometrioma size were recorded. The efficacy, compliance, and side effects of hormonal treatments were also assessed. Quality of Life (QoL) was measured using the SF-12 questionnaire at baseline and after six months of therapy. Results: Adolescents had earlier menarche (p<0.001), longer menstrual periods (p<0.001), and higher analgesic use (p=0.001) compared to adults. Dysmenorrhea was more frequent (p=0.01), lasted longer (p<0.001), and was associated with higher pain scores (p<0.001) in adolescents. CPP was more common in adolescents (p<0.001), often described as "confined" (p=0.04) and "oppressive" (p=0.038), while adults reported it as "widespread" (p=0.007). Headaches (p<0.001) and nausea (p=0.001) were also more frequent in adolescents. Both groups showed significant improvement in QoL with hormonal treatment (p<0.001) and reported minimal side effects. Conclusions: Adolescents with endometriosis often present with earlier menarche, longer menstrual periods, more severe dysmenorrhea, and atypical symptoms. Hormonal contraceptives and dienogest are effective and safe treatments, that improve pain and QoL.
Introduction to Geospatial Analysis for Business Analytics
Authors: Chasco Coro
Published: January 2025

Geospatial analysis has become essential in modern business analytics and decision-making processes. The unique nature of spatial data, being bidirectional and 360-degree oriented (unlike linear time series data), requires specific referencing systems using latitude-longitude coordinates and appropriate projections. Data can be represented in two main formats: raster (grid cells) and vector (points, lines, and polygons). Various digital map formats exist, both proprietary (like ESRI's Shapefile and MapInfo's TAB files) and open source (including GeoJSON, GeoPackage, and KML), each with different organizational structures and capabilities. These formats support the growing integration of geospatial analysis across sectors such as urban planning, site selection, and competitive intelligence. Platforms like ArcGIS, QGIS, and GeoDa have democratized access to geospatial analytics through user-friendly interfaces and visualization tools. These technologies enable professionals across industries to leverage spatial data effectively, enhancing operational efficiency and strategic planning through location-specific analysis and pattern recognition.
Methods for Estimating Flow Discharge in Ice-Covered Channels
Authors: Zhao Haojie , Mao Zeyu
Published: January 2025

River ice formation is common in high-latitude areas, where it significantly impacts the accuracy of river flow measurements. The most commonly used method to solve the ice-covered channel flow measurement problem is to combine physical boundary conditions, which effectively reduces the large amount of work required for measuring flow in frozen channels, especially for hard-to-obtain flow characteristic data. Through theoretical analysis, The research proposes a general formula applicable to flow discharge prediction in ice-covered channels. It is unaffected by the shape of the channel and somewhat unifies the flow prediction formulas for ice-covered channels. Two simplified flow discharge prediction formulas are proposed based on the general formula. Experimental data from the literature were collected to verify the applicability of the general formula and the two simplified formulas, comparing them with the Lotter, Sabaneev, Larsen, and Pavlovskiy formulas. The results show that the proposed general formula and the two simplified formulas are more accurate in estimating flow in ice-covered channels compared to traditional formulas.
Simple, Sensitive, and Reproducible High-Performance Liquid Chromatographic Method for Determination of Mixed Tocotrienol in Blood Plasma Using Fluorescent Detection
Authors: Thor Teong Gee , Goh Song Thai , Yuen Kah Hay , Mark Jacqueline Kar Kei , Chan Siok Yee
Published: January 2025

A simple, sensitive, and repeatable high-performance liquid chromatographic method using fluorescence detection was developed and validated for quantifying of mixed tocotrienols (α-, γ-, δ-) in human plasma. After deproteinization with a mixture of acetonitrile: tetrahydrofuran (3:2, v/v), the supernatant was directly injected into the HPLC system. The mobile phase was comprised of methanol. Analyses were conducted at a flow rate of 1.5ml/min with the detector operating at excitation wavelength of 296nm and emission wavelength of 330nm. The quantification limit is 4.6ng/ml for δ-T3, 19.2ng/ml for γ-T3, and 12.7ng/ml for α-T3, respectively. The mean absolute recovery values ranged from 85.0% to 111.2%, while the intra-day and inter-day relative standard deviations were all below 15%. The calibration curve was linear for α-, γ-, and δ-T3, at a concentration range of 12.7-2538.6ng/ml, 19.2-3839.3ng/ml, and 4.6-923.1ng/ml respectively. Moreover, only a small sample plasma volume (250µl) is required for the analysis, Overall, this method is validated with acceptable precision and accuracy, and can be used to analyse tocotrienol samples obtained from preclinical and clinical studies in a speedy and reproducible manner.
Expanding Indications in Transplant Oncology
Authors: Allkushi Erlind , Wehrle Chase J , Khalil Mazhar , Kwon David CH , Fujiki Masato , Pinna Antonio D , Miller Charles , Schlegel Andrea , Aucejo Federico , Hashimoto Koji , Pita Alejandro
Published: January 2025

Liver transplantation is well described as the only curative treatment for cirrhosis and cirrhosis with co-morbid hepatocellular carcinoma (HCC). However, it’s utility in the management of various other primary and secondary liver cancers is gaining traction rapidly, with more thorough and broader populations continuing to qualify. This includes most prominently colorectal cancer liver metastasis (CRLM), as well as cholangiocarcinoma (CCA), neuroendocrine tumors (NET) and more. Furthermore, despite being a well-described treatment for HCC for many years, growing evidence supports a change in oncologic strategy for HCC, with broadened selection criteria and more advanced systemic and loco-regional therapies.

Our review aims to describe the evidence supporting expanding indications and selection criteria for liver transplantation for various oncologic indications of primary and secondary liver tumors.
Capturing the Owners Experience and Dealer’s Outlook and Their Policy Recommendation for the World’s Biggest EV Laggard. Case of Kuwait
Authors: Ottesen Andri , Navfal Mohammed , Hamwi Hidab , Al-Kous Abdulazis
Published: January 2025

As of end of June 2024, there are only about 597 Electric Vehicles (EV) on the streets of Kuwait, which is about 0.024 percentile of total car populations or about the lowest EVitization worldwide. In this paper we captured gains and pains of owning Electric Vehicle in Kuwait with the recommendation of 12 Kuwait EV owners through deep interviews. Furthermore, we in-terviewed dealers selling European, USA, Chinese and Korean EVs on how they see the future of EV’s in Kuwait; what needs to be changed to gain mass appeal and what are the main reasons they give for the ultra-low adoption as of late. Special attentions are given to which EVs model and sub-model have been sold and which models of EVs are likely to be successful in Kuwait if certain policy, implementation and social conditions are met in the near future. Finally, conditional EV sales prediction is made depending on set infrastructural changes as well as who would be the early majority and what their preference would be.
Research on the Optimization of Omnichannel Marketing Strategies for Tea Enterprises under the Background of Digital Economy: A Case Study of Shan Guo Yin Yi
Authors: Fu Bingsheng , Lin Dongkai , Lin Jinke
Published: January 2025

With the development of the global digital economy, marketing in various industries is gradually transforming and upgrading towards digitalization, and omnichannel marketing has become the latest model for marketing upgrading in various industries. Omnichannel marketing for tea companies encourages them to sell and promote their products through various online and offline channels, as well as accumulate data resources to provide data support for product innovation, brand building, market expansion, and decision-making. This study is based on the PEST theory, the Five Forces model theory, the precision marketing theory, and the consumer behavior theory, and uses interview methods and grounded theory to conduct research on tea enterprises. Through research and analysis of 81 middle and senior managers in the marketing departments of tea companies, it was found that there are 7 factors that affect the omnichannel marketing of tea companies, namely: (1) The product promotion channel is relatively single. (2) The inventory issue is prominent. (3) The degree of integration between online and offline is poor. (4) The current marketing campaign lacks appeal. (5) The user service experience feels poor. (6) Data analysis and precision marketing are still insufficient. (7) The brand image is still poor. Based on the grounded theory, the research and analysis of tea enterprises have yielded seven targeted strategies for optimizing omnichannel marketing in the context of the digital economy: (1) Expand the existing marketing channels. (2) Promote digital inventory management. (3) Online and offline combination can be carried out based on "Internet plus data". (4) Enhance the attractiveness of scenario based marketing activities. (5) Enhance the overall user service experience across all channels. (6) Strengthen data processing capabilities. (7) Create a unique KOL image for tea companies. The purpose of this study is to provide theoretical basis for optimizing omnichannel marketing for tea enterprises, and to provide some reference for the transformation and development of omnichannel marketing for tea enterprises in other countries around the world. It is expected to better adapt to the development trend of the digital economy era and promote the high-quality development of the global tea industry.
The “Publish or Perish” Phenomenon: Origins and Evolution
Authors: Moskovkin Vladimír
Published: January 2025

The question of the origin of the phrase "publish or perish" was first raised by Eugene Garfield (1925 - 2017) in 1996. The date of the first publication using the phrase is now set at 1928, when the work of the sociologist Clarence Marsh Case (1874-1946) was published, although Isaiah Bowman (1878 – 1950) in 1934 and Robert Speight (1867 – 1949) in 1935 were convinced that the phrase was used by the American geographer William Morris Davis (1850 – 1934) in 1904. We found a German-language work by the Swiss historian Werner Kaegi (1901 - 1979), published in 1973, which noted that the phrase in question was used by the Swiss historian of art and culture Carl Jacob Christoph Burckhardt (1818 - 1897). Taking into account the years of this scholar's life, we moved the upper limit of the phrase's use from the beginning of the 20th century to the end of the 19th century, and also shifted the area of its origin from America to Europe. We shifted the meaning of the phrase "publish or perish" from its positive meaning (unpublished knowledge perishes) to a negative one, when a scientist's career progression depends on the number of publications. It is shown that the change in the meaning of this phrase from a wish for scientists to publish their new results to a dictum elevated to the rank of university policy is associated with the President of Harvard University (1933 - 1953) James Bryant Conant (1893 - 1978). It is proposed to include the approximate date of origin of the "publish or perish" phenomenon in the table of major historical milestones in the progress of open research publishing proposed by J.P. Tennant et al. in 2016. In conclusion, the reflection on the "publish or perish" phenomenon has allowed us to construct a cyclical scheme of the birth and death of knowledge, from oral knowledge to digital and open access knowledge.
Relationship Between Purposeful Rumination and Post-Traumatic Growth of College Students Who Experienced Childhood Trauma: A Regulated Intermediary Model
Authors: Zhao Sanglin
Published: January 2025

The purpose of this study is to explore the relationship between positive coping and post-traumatic growth in trauma experiencers, as well as the mediating role of positive coping and the moderating role of social comprehension support (family support). Methods: In this study, 、811 college students aged 18-28 who had traumatic experience were selected through the Traumatic Events Lifelong Experience Questionnaire (Student Version) as the research subjects, and the survey covered many provinces in China, and the purpose rumination scale, post-traumatic growth and positive coping scale and social comprehension rating scale were used for investigation. Results: Correlation analysis showed that purposive rumination, positive coping and post-traumatic growth were significantly correlated. Regression analysis showed that purposive rumination had a significant direct effect on post-traumatic growth (β=0.148, P<0.001) . The results of the mediated moderation model showed that positive coping and social comprehension support played a chain mediating role in the relationship between purposive rumination and post-traumatic growth, and social comprehension support played a moderating role in the relationship between positive coping and post-traumatic growth. Furthermore, the simple slope analysis showed that the predictive effect of purposive rumination on PTG was not significant when the perceived social support was high, and the positive predictive effect of purposive rumination on PTG was significant when the perceived social support was low, indicating that the predictive effect of purposive rumination on PTG gradually increased with the decrease of perceived social support.
Application of Ultrafiltration for Recovery of Bioactive Phenolic Compounds from Rose Wastewater
Authors: Dushkova Mariya , Mitova Marina , Bakardzhiyski Ivan , Miteva-Petrova Milena , Menkov Nikolay
Published: January 2025

The purpose of this work was to investigate the posibilties of ultrafiltration with three polyacrylonitrile membranes (molecular weight cut-off 1 kDa, 10 kDa, and 25 kDa) to recover the total polyphenolic compounds, phenolic acids and flavonoids from rose wastewater. The permeate flux, energy demand, contents of total polyphenolic compounds, phenolic acids and flavonoid phenolic compounds were determined during ultrafiltration at volume reduction ratio of 2, 4, 6 and 8, and the rejections and concentration factors were established. The permeate flux decreased with the rise in the volume reduction ratio, and with the decrease in the transmembrane pressure and the molecular weight cut-off of the membranes. Inverse relationship was observed between the permeate flux and the energy demand at the same operating conditions. The rejections and concentration factors of total polyphenolic compounds, phenolic acids and flavonoid phenolic compounds rose with the increase in the volume reduction ratio for all membranes. The 1 kDa membrane had higher concentration and rejection effectiveness than 10 and 25 kDa membranes. Protocatehuic and vanillic acid, determined by using HPLC, increased in the retentate when 1 kDa membrane was used, while gallic acid, catechin, p-coumaric acid, rutin, hesperidin, rosmarinic acid decreased.
Real-World Analysis of Adherence to Abemaciclib and Endocrine Therapy in Women With HR+/HER2- Breast Cancer
Authors: Valerio Maria Rosaria , Martorana Federica , Sanò Maria Vita , Sambataro Daniela , Motta Gianmarco , Motta Lucia , Pavone Giuliana , Gebbia Vittorio , Scandurra Giuseppa
Published: January 2025

Background: Adherence to oral anticancer therapies among breast cancer patients is an often-overlooked issue. Lack of patients’ compliance can be caused by several factors, and may hinder the efficacy of prescribed medication, determining shorter than expected survival. In this context, few data are available about adherence to CDK4/6 inhibitors in the real-world practice. We report here the results of a retrospective analysis of adherence to abemaciclib plus endocrine therapy in cohort of women with hormone receptor-positive (HR+), epidermal growth factor 2 negative (HER2-) breast cancer. Methods: Abemaciclib adherence was computed as the ratio between the total number of cycles/months of supply for medication and months between the first and the last prescription. The proportion of Days Covered (PDC) may range from 0 to 1. A score of 0.8 (i.e. 80% adherence rate) was the cutoff to classify the patients as adherent (0.8 ≤ PDC ≤1) or non-adherent (0 ≤ PDC <0.8). Received dose intensity was also calculated. Results: Abemaciclib pharmacy claims of 100 women with HR+/HER2- breast cancer were retrieved. Most patients (91%) were treated in the advanced setting. Abemaciclib were more frequently taken with an aromatase inhibitor (63%), than with fulvestrant (27%). In this population, adherence rate was high (92.25% + 1.939 SD). The proportion of non-adherent patients taking abemaciclib with PDC <0.8 was 12%. There was a significative correlation between the occurrence of side effects and polypharmacy, probably reflecting concomitant non-oncological diseases. Conclusions: Adherence to abemaciclib-based therapy is high in a real-life setting, pending adequate and proactive management of patients. Careful patients’ evaluation and detailed information about expected adverse events are essential to ensure adherence to this antineoplastic agent.
A Combined Optimization Method for the Transition Control Schedules of Aero-Engines
Authors: Hao Wang , Zhang Xiaobo , Li Baokuo , Wang Zhanxue , Li Dawei
Published: January 2025

A well-designed transition control schedule can enable the engine to quickly and smoothly transition from one operating state to another, thereby enhancing the maneuverability of the aircraft. Although traditional pointwise optimization methods are fast in solving the transition control schedules, their optimized control schedules suffer from fluctuation problems. While the global optimization methods can suppress the fluctuation problems, their slow solving speed makes them unsuitable for engineering applications. In this paper, a combined optimization method for the transition control schedules of aero-engines is proposed. This method divided the optimization of the control schedules into two layers. In the outer-layer optimization, the global optimization technique was utilized to suppress the fluctuation of geometrically adjustable parameters. In the inner-layer optimization, the pointwise optimization technique was adopted to quickly obtain the control schedule of fuel flow rate. Moreover, a construction method of non-uniform control points in the global optimization layer was proposed, which significantly reduced the number of control points that needed to be optimized and thus improved the efficiency of global optimization. The optimization problem of the acceleration and deceleration control schedules of a mixed-flow turbofan engine was used to verify the effectiveness of the combined optimization method. The results show that, compared with the pointwise optimization method, the transition time optimized by the combined optimization method shows no obvious difference. The control schedules optimized by the combined optimization method are not only smooth but also can prevent some components from approaching their working boundaries.
UVA as a Stress and the Influences of Provenance and Leaf Age on the Expression of Phenolic Compounds by Eucalyptus camaldulensis ssp. camaldulensis
Authors: Khanal Santosh , Rochfort Simone J. , Steinbauer Martin J.
Published: January 2025

UV radiation represents a significant abiotic stress to green plants for which phenolic compounds have been suggested to be a component of their photoprotective adaptations. We used a unique combination of experimental (LED lighting and leaf tagging) and analytical (unbiased metabolomics) approaches to study the effects of high (approximating mid-summer) and low (approximating winter) UVA on the expression of phenolic compounds by five provenances of river red gum (Eucalyptus camaldulensis ssp. camaldulensis). The geographically separated provenances used in our study span the lowest and highest latitudes of the range of this subspecies. Gallotannins and ellagitannins (i.e. hydrolysable tannins) increased most in concentration under high UVA but responses differed only slightly among provenances. The most substantial changes in the composition of phenolic compounds were associated with leaf age. Three-month-old (termed herein ‘young’) leaves had substantially different phenolic compositions to six- and 12-month-old (‘old’) leaves. Hydrolysable tannins were more abundant in young leaves whereas pedunculagin, catechin and kaempferol galloyl glucoses were more abundant in old leaves. High UVA altered the expression of phenolic compounds but our experimental saplings were unlikely to have experienced photoinhibition because they were not exposed to high light and low temperature – nor were they nitrogen limited. We expect that changes in phenolic compounds may have been more pronounced if we had induced photoinhibition.
Development of an Acid-Soluble Residue-Free Drill-In Fluid: Eliminating Reservoir Damage with Waxy Corn Starch
Authors: You Fuchang , Pu Lei , Qin Yi , Wu Yu , Zheng Yancheng
Published: January 2025

Completely removing and dissolving the mudcake formed by drill-in fluid (DIF) without any residue is a challenging and complex task during the well completion process, as mudcake removal involves polymer degradation and dissolution of filtration reducer. As a traditional technique, a combination of gel breakers and acids is applied to remove mudcake; this method can degrade polymers and dissolve acid-soluble materials, such as calcium carbonate, but it cannot dissolve filtration reducers, such as starch. This drawback allows filtration reducers to easily enter reservoir pores, eventually causing particle blockage damage that is difficult to be removed by inorganic or organic acids. In this study, based on the acid hydrolysis rates (AHRs) of waxy corn starch (WCS) and normal corn starch (NCS), the differences in turbidity of the resulting solutions, and the characteristic of the acid-hydrolyzed WCS without residue, an acid-soluble residue-free DIF (RF-DIF) was developed using WCS as a filtration reducer. Acid residue tests of the mudcakes formed by the DIF on the discs were conducted, and the microscopic pores within the discs were analyzed. Moreover, the reservoir protection performance of the DIF was evaluated, and the pore distribution and connectivity of the treated cores were reconstructed. The experimental results showed that the outer and inner mudcakes formed by DIF containing WCS (Waxy-DIF), which appeared on the surface and inside of the ceramic filter discs, respectively, could be completely dissolved by acid, resulting in the acid solution with a turbidity of less than 30 nephelometric turbidity units (NTU). By comparison, the mudcakes formed by the DIF with NCS (Normal-DIF) could not be completely dissolved by acid, leading to high turbidity. In addition, under the same conditions, the permeability recovery rates of the cores treated with Waxy-DIF and Normal-DIF were 100% and 83.17%, respectively, indicating that Waxy-DIF was more effective in protecting the reservoir, which can meet the needs of oil and gas production.
Building information modelling of tension supporting elements for ground reinforcement using parametric design
Authors: Chiu Jessica Ka Yi , Erharter Georg H. , Roset Olav , Rebhan Mattias J. , Li Charlie Chunlin
Published: January 2025

Building Information Modelling (BIM) finds increasing appreciation in geotechnical engineering but requires efficient means of modelling and functional data structures. The lack of both is a typical obstacle for many BIM projects. In response, this paper demonstrates parametric BIM modelling at the example of tension supporting elements (i.e. anchors, soil nails, rockbolts etc.) which are used in almost every geotechnical project. A generalisable and scalable BIM data structure for tension supporting elements is proposed that is applicable throughout a project’s life cycle from planning to maintenance. The data structure describes the required Level of Development (LOD) for geometries and metadata in correlation with project progress. Project cases in Norway are used to demonstrate BIM modelling of rockbolts in tunnels, slopes and foundation works. The data structure is expandable such that maintenance-related information at different periods can be appended and back-traced. Even though realisation and testing in real projects are necessary, the proposed data structure is already proven to be compatible with parametric design, the most used LOD frameworks, and common data exchange formats e.g. “Industry Foundation Classes” for BIM.
Accelerated biological aging, inflammatory bowel disease, genetic susceptibility and life expectancy: Evidence from UK Biobank and All of Us Cohorts
Authors: Chen Hao , Li Lingyi , Zhang Han , Zhang Lijun , Long Yu , Feng Jing , Ma Yuying , Wu Yanjun , Meng Meijun , Zeng Ruijie , Luo Dongling , Wang Yi , Leung Felix , Duan Chongyang , Sha Weihong
Published: January 2025

Background: Inflammatory bowel disease (IBD) is a chronic condition affecting individuals across all age groups. However, the association between IBD and biological aging remains unclear.
Methods: We utilized data from the UK Biobank and the diverse cohort of the All of Us (AoU) Research Programme to investigate the role of biological aging in the development of IBD and its subtypes. Biological age was assessed using the Klemera-Doubal method (KDMAge) and phenotypic biological age (PhenoAge), with KDMAgeAccel and PhenoAgeAccel defined as the residuals of chronological age minus KDMAge and PhenoAge, respectively. We assessed the impact of accelerated biological aging on life expectancy in patients with IBD through survival analysis. Additionally, we examined genetic susceptibility and its potential mediating effects on the association between biological aging and IBD.
Findings: In the UK Biobank, accelerated biological aging was associated with an increased risk of IBD (KDMAgeAccel: HR 1.22, 95% CI 1.13-1.32; PhenoAgeAccel: HR 1.57, 95% CI 1.46-1.69). This association was further validated in the AoU cohort, where PhenoAgeAccel was also linked to an elevated risk of IBD (HR 1.57, 95% CI 1.18-2.09). An additive interaction was observed between accelerated biological aging and genetic risk for IBD. Individuals with both high genetic risk and accelerated aging exhibited the highest risk of developing IBD (KDMAgeAccel: HR 1.36, 95% CI 1.20-1.53; PhenoAgeAccel: HR 1.59, 95% CI 1.41-1.79). Life expectancy analysis indicated that IBD patients with accelerated biological aging experienced a significant reduction in life expectancy, with an average decrease of 1.36 years (KDMAgeAccel) and 1.95 years (PhenoAgeAccel). Mediation analyses suggested that accelerated biological aging partially mediated the protective effects of dried fruit and cooked vegetables on the risk of developing IBD. Results from multistate modelling showed that PhenoAgeAccel was also significantly associated with an increased risk of IBD occurrence to mortality (HR 1.44 [95% CI 1.17-1.77]).
Interpretation: Biological aging is significantly associated with the risk of IBD and its subtypes, especially in individuals with high genetic susceptibility, and it reduces life expectancy in these patients. Identifying individuals with accelerated biological aging can serve as a marker for the effective prevention and management of IBD.