bluuebunny/crossref_metadata_2025 huggingface dataset:
Water stewardship through innovative policy development: mobilization and transfer of the Yinka Dene Water Law
Authors:   , DeLorey Rebecca
Published: November 2021

Policy mobility and transfer play a role in larger policy development and implementation processes, as actors look elsewhere for policy solutions to local issues. Conducted in collaboration with the Nadleh Whut’en First Nation and guided by an Indigenous methodology based on the Too Declaration with support from constructivist grounded theory, this research explores the mobilization and transfer of the Yinka Dene Water Law. Conversations with participants representing First Nations and interest groups reveal that the Water Law is being mobilized by individuals and groups at a variety of scales, and use varies from adoption and implementation, to inquiring about its transfer. This research also discusses factors influencing Water Law transfer, including shared policy problems and its function as a communication tool. There are few empirical examples of policy transfer processes between Indigenous contexts. This research contributes to filling this gap in the policy transfer literature by exploring such transfer between First Nations, and advances Nadleh Whut’en’s stewardship and implementation related objectives.
Sobre Ingrid Simson y Guillermo Zermeño Padilla (eds.), La historiografía en tiempos globales
Authors: Domenech Hernández Grethel
Published: November 2021

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Adamalizyny jako potencjalne biomarkery w wybranych nowotworach złośliwych przewodu pokarmowego
Authors: Sikora-Skrabaka Magdalena , Walkiewicz Katarzyna , Nowakowska-Zajdel Ewa
Published: November 2021

Abstrakt

Nowotwory złośliwe przewodu pokarmowego zajmują czołowe miejsce zarówno wśród przyczyn zachorowań jak i zgonów z powodu chorób nowotworowych na świecie. Wciąż poszukuje się potencjalnych biomarkerów, które mogłyby posłużyć jako czynniki predykcyjne i prognostyczne w tych nowotworach. Wśród białek, które mogłyby pełnić taką rolę, wymienia się adamalizyny. Liczne białka z tej rodziny są zaangażowane w wielu etapach nowotworzenia, od procesu różnicowania się pojedynczych komórek, wzrost i progresję guza do tworzenia przerzutów odległych. Dzieje się to m.in. poprzez ścieżki sygnałowe związane z aktywacją insulinopodobnych czynników wzrostu, naskórkowych czynników wzrostu czy oddziaływanie na czynnik martwicy nowotworu TNF-α. Szczególnie istotna w wyjaśnieniu patomechanizmu rozwoju raków gruczołowych przewodu pokarmowego wydaje się ścieżka sygnałowa związana z aktywacją cytokin prozapalnych. Przewlekły stan zapalny jest bowiem dobrze udokumentowanym czynnikiem ryzyka rozwoju tej grupy chorób nowotworowych.

Poznanie roli białek z rodziny adamalizyn w rozwoju i patogenezie nowotworów złośliwych przewodu pokarmowego wymaga wciąż dalszych badań. W artykule podjęto próbę syntezy aktualnej wiedzy na temat wykorzystania wybranych białek z rodziny adamalizyn jako biomarkerów nowotworów złośliwych przewodu pokarmowego.
Wpływ mikrobioty jelitowej na występowanie zaburzeń psychicznych oraz chorób neurodegeneracyjnych
Authors: Frej-Mądrzak Magdalena , Kołodziej Patrycja , Sarowska Jolanta , Jama-Kmiecik Agnieszka
Published: November 2021

Abstrakt

W artykule podsumowano aktualny stan wiedzy na temat zależności między składem mikrobioty jelitowej a występowaniem zaburzeń psychicznych i chorób neurodegeneracyjnych.

Patogeneza zaburzeń psychicznych oraz chorób neurodegeneracyjnych może mieć związek ze składem bioty bakteryjnej jelit. Komunikacja między jelitami a mózgiem jest możliwa za pośrednictwem osi jelitowo-mózgowej i odbywa się za pomocą mechanizmów endokrynnych, neuronalnych i immunologicznych.

Skład mikrobioty jelitowej człowieka w trakcie jego życia podlega fluktuacjom. Bakterie jelitowe pełnią wiele funkcji, które są korzystne dla zdrowia gospodarza. Pod wpływem czynników środowiskowych może wystąpić dysbioza jelitowa – stan zaburzenia jakościowego i ilościowego bioty bakteryjnej jelit.

Istnieją wyraźne różnice między składem mikrobioty jelitowej osób ze zdiagnozowanymi zaburzeniami psychicznymi a składem mikrobioty jelitowej osób zdrowych. W schorzeniach takich jak depresja, schizofrenia czy autyzm stwierdza się dysbiozę jelitową, której skutkiem jest zmniejszenie integralności bariery jelitowej, a następnie przemieszczenie do krążenia ogólnego drobnoustrojów oraz ich produktów.

U osób ze zdiagnozowanymi chorobami neurodegeneracyjnymi (choroba Alzheimera, Parkinsona) skład bioty bakteryjnej jelit jest odmienny w porównaniu do osób zdrowych. Wybrane typy bakterii, za pośrednictwem osi jelitowomózgowej, mogą wpływać na procesy zachodzące w mózgu.

Istnieją zależności między składem mikrobioty jelitowej a występowaniem zaburzeń psychicznych i chorób neurodegeneracyjnych u ludzi. Są związane przeważnie z występowaniem dysbiozy jelitowej oraz zespołu nieszczelnego jelita.
Budowa IV systemu sekrecji Legionella pneumophilai jego znaczenie w patogenezie
Authors: Kowalczyk Bożena , Małek Agata , Palusińska-Szysz Marta
Published: November 2021

Abstrakt

Bakterie Legionella pneumophila w środowisku naturalnym pasożytują wewnątrz komórek wybranych gatunków pierwotniaków, a po przedostaniu się do sztucznych systemów dystrybucji wody stają się ważnym czynnikiem etiologicznym zapalenia płuc u ludzi. Główną cechą determinującą patogenność tych bakterii jest zdolność do życia i replikacji w makrofagach płucnych, czyli w komórkach wyspecjalizowanych do fagocytozy, zabijania i trawienia mikroorganizmów. Warunkiem wstępnym rozwoju infekcji jest przełamanie mechanizmów bójczych makrofagów i utworzenie wakuoli replikacyjnej LCV (Legionella containing vacuole). Biogeneza wakuoli LCV jest możliwa dzięki sprawnemu funkcjonowaniu IV systemu sekrecji Dot/Icm, który jest wielobiałkowym, złożonym kompleksem umiejscowionym w wewnętrznej i zewnętrznej membranie osłony komórkowej bakterii. System Dot/Icm liczy 27 elementów, na które składają się m.in. kompleks rdzeniowo-transmembranowy, tworzący strukturalny szkielet całego systemu oraz kompleks białek sprzęgających. Geny kodujące komponenty systemu Dot/Icm są zorganizowane na dwóch regionach chromosomu bak-teryjnego. System sekrecji Dot/Icm umożliwia L. pneumophila wprowadzenie do cytozolu komórki gospodarza ponad 300 białek efektorowych, których skoordynowane działanie powoduje utrzymanie integralności błony wakuoli replikacyjnej oraz pozwala na manipulowanie różnymi procesami komórki. Ważnym elementem strategii wewnątrzkomórkowego namnażania się L. pneumophila jest modulowanie transportu pęcherzykowego, interakcja z retikulum endoplazmatycznym oraz zakłócenie biosyntezy białek, procesów autofagii i apoptozy komórki gospodarza. Poznanie złożonych mechanizmów regulacji i funkcji białek efektorowych systemu Dot/Icm ma decydujące znaczenie w zapobieganiu i leczeniu choroby legionistów.
Badania kopalnego DNA – możliwości i ograniczenia
Authors: Wasiak Tomasz , Strózik Tadeusz
Published: November 2021

Abstrakt

Ostatnie cztery dekady przyniosły znaczący rozwój archeologii molekularnej i badania nad kopalnym DNA (aDNA). Nowatorskie metody uwzględniają szeroki zakres badań, począwszy od sekwencjonowania niewielkich fragmentów mitochondrialnego DNA po wielkoskalowe badania całych populacji, łączące sekwencjonowanie genomów mitochondrialnych, genów podlegających doborowi naturalnemu, jak i całych genomów jądrowych. Postęp, zwłaszcza w dziedzinie technologii sekwencjonowania DNA, umożliwił pozyskanie informacji ze szczątków paleontologicznych i materiału archeologicznego, umożliwiając zbadanie związków filogenetycznych między wymarłymi i współczesnymi gatunkami. Dzięki zastosowaniu technologii sekwencjonowania nowej generacji możliwe stało się poznanie sekwencji DNA nie tylko bezpośrednio ze szczątków ludzkich lub zwierzęcych, ale także z osadów sedymentacyjnych z głębin jezior oraz jaskiń. W artykule przedstawiono możliwości i ograniczenia występujące w badaniach nad kopalnym DNA ludzi, zwierząt czy bakterii z podkreśleniem wkładu polskich badaczy w rozwój tej dziedziny nauki.
Diagnostic significance of blebbing formation of cytoplasmic membranes in lymphocytes and neutrophils in assessing the clinical condition in diabetic foot syndrome
Authors: Mikhailov A. Yu. , Khalimov E. V. , Styazhkina S. N. , Solovev A. A. , Vasiliev A. D. , Zhuikova A. A.
Published: November 2021

The OBJECTIVE was to study the nature of blebbing formation of peripheral blood leukocytes in patients with diabetic foot syndrome, the effect of treatment on this process.

METHODS AND MATERIALS. The data of treatment of patients of the Department of Purulent Surgery of the City Clinical Hospital No 6, Izhevsk, 2019–2020 (clinic of the Department of General Surgery of Izhevsk State Medical Academy) were analyzed. 2 groups of patients with diabetic foot syndrome n1 (Meggit – Wagner 1–2) and n2 (Meggit – Wagner 0) were formed. The blebbing formation of neutrophils and lymphocytes, parameters of integral leukocyte indices, data of the scale of the general assessment of neuropathy and the Michigan screening test, indices of planimetry of ulcerative defects were studied.

RESULTS. It was revealed that the blebbing formation of neutrophils and lymphocytes in the studied groups was different, which was reflected in a decrease in these indices in the n1 group and an increase in the n2 group. Integral indices revealed a decrease in immunoreactivity and nonspecific reactivity. In the dynamics of treatment, there was an improvement in the data of the scale of general neuropathy and the Michigan screening test.

CONCLUSION. The studied indices of blebbing formation correspond to the indices of the leukocyte integral indices, the diagnostic scales for neuropathy, reflect the severity of the wound process. The study of blebbing provides objective data on the dynamics of the immune status of patients with diabetic foot syndrome, which allows improving treatment results.
Trichobezoars of the stomach and jejunum, complicated by partial obturation intestinal obstruction
Authors: Markosyan S. A.
Published: November 2021

The article describes the stages of diagnostics and treatment of a child with the stomach and jejunum trichobezoars, starting from the regional hospital and ending with a children’s medical republican institution. The operation, which was performed 2 days after the child’s hospitalization, consisted in enterotomy, gastrotomy and the trichobezoars extraction. The postoperative period was uneventful. The significant difficulty in trichobezoars recognition in children requires the development of an action algorithm at all stages of the diagnostic process.
Laparoscopic pyeloplasty of the pyeloureteral segment: our experience
Authors: Al-Shukri A. S. , Ponomareva Ju. A. , Reva S. A. , Ammo R. M. , Kostuykov S. V. , Petrov S. B.
Published: November 2021

The OBJECTIVE of the study was to analyze the results and to introduce our experience of the laparoscopic pyeloplasty regarding the stricture of the pyeloureteral segment.

METHODS and MATERIALS. Our study represents results of treatment of 114 patients who had surgical treatment during the years 2013–2018. In that period, we made 114 primaries and 9 secondaries laparoscopic pyeloplasties with transperitoneal access. In this account, there were 43 men aged from 19 to 64 years, average age was (34.9±3.7), and 71 women aged from 19 to 77 years, average age was (39.2±4.2). All patients underwent ultrasound examination of the kidneys on the day of discharge and 3-5 days after stent extraction. Control examination, which included history taking, examination, clinical and biochemical blood analyses, clinical urine analysis and ultrasound of the kidneys were performed after 3 months. Plain and excretory urography were performed 6 and 18 months after surgical intervention. 

RESULTS. Operative removal of the stricture of the pyeloureteral segment was successful in 105 (92.2 %) out of 114 cases. 9 patients (7.8 % of the total number of operated patients) underwent repeated laparoscopic pyeloplasty. Duration stay after primary laparoscopic pyeloplasty was from 3 to 5 days, on average (3.9±0.7) days. Postoperative period after secondary pyeloplasty was without complications, the bed-day was from 3 to 6 days, on average (4.3±0.6) days.

CONCLUSION. Our opinion is that the optimal method for surgical treatment of patients with primary and secondary strictures of the pyeloureteral segment is laparoscopic pyeloplasty. This kind of surgery has a favorable security profile and optimal postoperative results. Considering the possible causes of relapse of the stricture of the pyeloureteral segment, we came to the conclusion that the frequency of relapse is mainly connected with selected suture material, which determines the severity of scar changes.
Successful treatment of advanced tuberculosis of a single lung with staged correction of post-pneumonectomy syndrome
Authors: Tarasov R. V. , Krasnikova E. V. , Lepekha L. N. , Salikhov B. U. , Aliev V. K. , Bagirov M. A.
Published: November 2021

An observation from practice is given – surgical treatment of a patient with advanced tuberculosis of a single lung and a pronounced lung displacement. Patient A., 47 years old, after 3 months from the left pneumonectomy for fibrocavernous tuberculosis complained of dyspnea at rest, and dysphagia, underwent CT scan, which showed a pronounced displace ment of a single right lung with tuberculoma to the left. At the first stage of the surgery, the overstretched section of a single lung with tuberculoma was resected, the displaced lung was put back and a hernial orifice was strengthened with a mesh implant. At the second stage, the extrapleural thoracoplasty was made with resection of I–IV ribs from the side of pneumonectomy to reduce the volume of the left hemithorax and prevent relapse of mediastinal hernia. As a result, the patient stopped dyspnea and dysphagia, radiographically a single right lung was visualized in the right hemithorax.
An experience of the treatment of a patient with chronic pancreatitis with pancreatic pleural fistula complicated by lung abscesses
Authors: Kokhanenko N. Yu. , Kashintsev A. A. , Bobylkov A. A. , Avanesyan R. G. , Shepichev E. V. , Ivanov A. L. , Glebova A. V. , Vavilova O. G. , Medvedev K. V. , Solovyova L. A.
Published: November 2021

Pancreatic pleural fistula is one of the rare and difficulty verifying complication of chronic pancreatitis. We present a rare medical case of a patient with chronic pancreatitis complicated by pancreatic pleural fistula with the formationof multiple lung abscesses. At the same time, the success of the treatment of the patient was due to the staged treatment and the participation of a multidisciplinary team of specialists.
Simultaneous gastrectomy with D2-lymph dissection and prosthetics of the occluded branch of the bifurcation endoprosthesis
Authors: Kalinin R. E. , Suchkov I. A. , Karpov V. V. , Zaitsev O. V. , Gerasimov A. A. , Egorov A. A. , Karpov D. V. , Pshennikov A. S.
Published: November 2021

The article provides an example of successful simultaneous surgical treatment of a patient with a thrombotic complication after endovascular intervention (Endovascular aneurysm repair, EVAR) in the long-term postoperative period (2 years) in the presence of concomitant gastric cancer, detected during a follow-up examination before planned surgery.
Interdisciplinary approach and staged treatment of a patient with Crohn’s disease complicated by stricture of the ileum with penetration and the formation of enterovesical fistula
Authors: Osmanov Z. Kh. , Shchukina O. B. , Morozov V. P. , Kamanin A. A. , Bogdanov P. I. , Korol’kov A. Yu. , Vinichenko A. A. , Pozdnyakova V. G. , Zaytseva M. I. , Demin A. N. , Ganich E. G.
Published: November 2021

An observation from practice was devoted to the experience of an interdisciplinary approach in the diagnosis and surgical treatment of a patient with complicated course of Crohn’s disease against the background of the formation of a stricture of the terminal ileum, an enterovesical fistula, the penetration into the mesentery of the sigmoid colon.
Arthrodesis of the ankle joint with LCP plate from the posterior surgical approach in a patient with renal osteodystrophy (hemodialisys)
Authors: Tsed A. N. , Iljushenko K. G. , Mushtin N. E. , Shmelev A. V. , Schepkina E. A. , Dulaev A. K.
Published: November 2021

In cases when there is a need to visualize the posterior part of the tibia and talus, the subtalar joint and the possibility of performing osteosynthesis or arthrodesis, the most optimal is the posterior surgical approach. The article presents a demonstration of successful arthrodesis of the ankle joint using an LCP plate with angular stability of screws from the posterior surgical approach in a patient with renal osteodystrophy receiving renal replacement therapy. The result of treatment according to the AOFAS scale 4 months after the operation was 70 points, the severity of pain according to the VAS was 1/2 point. Clinical and radiological characteristics were assessed as satisfactory, taking into account the severity of the deformity and the severity of osteoporosis against the background of concomitant pathology.
Commentary on the article by A. I. Ivanov et al. «Endoscopic stenting for esophageal anastomoses leakage (review of literature)»
Authors: Dvoretski S. Iu.
Published: November 2021

Ivanov A. I., Popov V. A., Burmistrov M. V. Endoscopic stenting for esophageal anastomoses leakage (review of literature). Grekov’s Bulletin of Surgery. 2021;180(3):87–93. (In Russ.)
Oscillation Criteria of Solutions of Third Order Neutral Integro-Differential Equations
Authors: Abed Taghreed Hussein , Ketab Sattar Naser , Mohamad Hussain Ali
Published: November 2021

Some necessary and sufficient conditions are obtained that guarantee the oscillation of all solutions of two types of neutral integro-differential equations of third order. The integral is used in the sense of Riemann-Stieltjes. Some examples were included to illustrate the obtained results
Displasia fibrosa na odontologia: entendendo a doença e como agir
Authors: Brazão-Silva Marco Tullio , Bacchi Ricardo Rodrigues , Da Silva Pabliano Micael Borges , Fernandes Marlon Santos
Published: November 2021

Objetivo: O objetivo do trabalho é relatar um caso de displasia fibrosa monostótica e apresentar achados bibliográficos importantes para o diagnóstico e conduta do cirurgião-dentista frente a esta doença. Caso clínico: A paciente de 28 anos compareceu ao consultório odontológico para avaliação de alteração percebida em boca, de crescimento lento, assintomática. Ao exame físico, apenas notou-se expansão rígida do rebordo póstero-superior esquerdo, por éticavestibular e lingual. A radiografia panorâmica revelou alteração do trabeculado em aspecto de vidro despolido. Realizada biópsia incisional confirmou-se o diagnóstico de displasia fibrosa. A revisão de literatura mostra que não é necessário tratamento em casos assintomáticos e sem desejo estético ou funcional. Dar o diagnóstico da displasia fibrosa é importante para o conhecimento do paciente sobre sua possível evolução e possíveis necessidades de tratamento. Conclusão: O cirurgião-dentista deve reconhecer e compreender essa doença para avaliar situações onde outros tratamentos são necessários e a possibilidade de realização de tratamento ortodôntico, implantodôntico, entre outros, diante a complexidade da doença.
Ação do diclofenaco de sódio e do celecoxibe na cicatrização por segunda intenção de feridas cutâneas de ratos wistar tratados com óleo de girassol
Authors: Da Silva Rafael Fernandes , Da Rocha Amanda Carolina Souza Delfino , Samprônio Maria Amélia Alves , De Camargo Mariana , Cresci Ana Rosa
Published: November 2021

O processo cicatricial é uma resposta do organismo frente a um dano ou agressão sofrida e que por meio de mecanismos fisiológicos, visa reparar o tecido lesado o reconstituindo e tornando-o novamente saudável. O trabalho teve como objetivo comparar os efeitos de dois anti-inflamatórios (diclofenaco e celecoxibe) na cicatrização, visto que são muito utilizados em pós-operatório e interferem no processo cicatricial. Os animais sofreram lesões cutâneas e dorsais, com aproximadamente 1 cm de diâmetro, e foram submetidos a tratamento com aplicação de óleo de girassol nas feridas, e gavagem com os dois tipos de medicamentos diferentes a cada vinte e quatro horas. Foram divididos em três grupos, sendo: G1 controle, G2 diclofenaco e G3 celecoxibe. No decorrer do processo cicatricial, foram avaliadas aos quatro, sete e quatorze dias de tratamento as seguintes características: presença de crosta leucocitária, presença de neutrófilos e basófilos, neo-vascularização, tecido de granulação e reepitelização do tecido lesado. Aos 14 dias de pós-operatório, os grupos controle e o grupo que ingeriu celecoxibe, apresentaram a ferida finamente fechada, mostrando que não houve interferência do medicamento nesse processo. Já o grupo que ingeriu diclofenaco de sódio a ferida não estava fechada totalmente, mostrando que houve atraso no processo de cicatrização.
Tratamento de sementes com micronutrientes na cultura do milho (Zea Mays l.)
Authors: Silva Lucas Antunes da , Oliveira Glauce Portela de
Published: November 2021

O objetivo foi avaliar o efeito do tratamento de sementes de milho (Zea mays) com nutrientes, no crescimento inicial de plantas em condições controladas (casa de vegetação) de acordo com protocolo comercial. Utilizou-se o delineamento experimental inteiramente casualizado, com 10 tratamentos e 5 repetições, sendo 9 tratamentos com produtos comerciais de diferentes composições e um tratamento padrão (testemunha). Aos 30 dias após a emergência realizou-se as avaliações de altura de plantas, diâmetro de caule, número de folhas, comprimento de raiz, massa seca (MS) da parte aérea e da raiz. Concluiu-se que, embora não sejam estatisticamente diferentes da testemunha, o tratamento de sementes de milho com produtos formulados promove acréscimo no comprimento de plantas de milho e incremento no alongamento e massa seca de raiz, aos trinta dias após a emergência.
The Prosody of Harar Oromo Nouns
Authors: Al Solami Majed
Published: November 2021

This paper examines the tone in Harar Oromo, a language widely spoken in Ethiopia. The focus is on tone in nouns. The examination implements acoustic analysis of tone using pitch contours, which helps in determining the type and position of tone in roots and in nominative and accusative case. The results show that roots can have either L or H tone, while case suffixes always have H tone. This suggests that tone is predictable in suffixes, but not in roots. The analysis suggests that Harar Oromo has a restricted tone system that is similar to stress-like languages.
Drama in Fostering Students’ Speaking Skills: A Systematic Review on Benefits and Problems
Authors: Astiandani Fitri Rahmawati , Mustofa Ali
Published: November 2021

Drama is pedagogy with a fairly complete component that involves the body, mind, emotions, and senses in order to build individual relationships with true-life situations so that being active in language learning is needed by students. This paper will closely explore the benefits and problems of implementing drama during the process of teaching and learning a language. In language teaching, drama has been proposed as an effective way to encourage the students’ speaking skills. Essentially, drama provides more benefits, not only in students’ speaking skills but also in other aspects. However, some problems may arise in the process of drama-based language teaching. By cross-checking and reviewing eclectically from different sources, this paper presents a critical analysis of several empirical works on drama techniques used in the context of language learning. To generalize the notion, drama is indeed precious in language learning. Nevertheless, several problems in its implementation need to be considered to achieve learning objectives properly. The review results showed that some problems that may appear during the implementation of drama were undisciplined in time management, chaotic atmosphere, the usage of the first language (L1), and status at school. Hence, several suggestions are provided as solutions to the drama problems confronted by teachers.
Rethinking the Education Paradigm in Morocco in the Covid-19 Context- Assessment of Resilience Curricula in Higher Education
Authors: Birrou Zineb , Kich Aziz , Larouz Mohammed
Published: November 2021

The Covid-19 pandemic has impacted mental and emotional health in significant ways, and has worsened the already existing crisis of rising anxiety, chronic stress and depression among the youth. This was particularly marked by the drastic lockdown measures, the incessant stream of bad news, and the sudden shift to online education. Faced with stressors, resilience is a skill-set that aids with adapting, coping, and bouncing back from adversity while maintaining or quickly returning to a relatively healthy psychological functioning. This article therefore aims to explore the past, present and future situation regarding emotional and mental resilience skills in Moroccan higher education curricula. To this end, structured and semi-structured interviews have been conducted with four senior officials at the Ministry of Education in Rabat, Morocco. Furthermore, surveys have been collected from faculty members in eight public universities. The findings reveal that resilience education has not been officially implemented yet in Moroccan universities. However, the national vision shows the rising awareness in the need to shift to a more holistic educational paradigm, especially in light of the Covid-19 pandemic, to better prepare students for the uncertain and fast-changing future.
Riscos toxicológicos dos corantes de tatuagens: uma revisão narrativa
Authors: Santos Juliana da Cruz , Matos Gabriela Santos , Silva Monique Coelho Batista da , Rodrigues Juliana Lima Gomes
Published: November 2021

Objetivo: Abordar por meio de uma revisão narrativa, os potenciais riscos toxicológicos à saúde humana associados aos corantes para tatuagens. Revisão bibliográfica: As tintas de tatuagens são frequentemente uma combinação de água, compostos orgânicos e álcool isopropílico. Contudo, essa composição é bastante variável a depender do fabricante, sendo também encontrados pigmentos inorgânicos, pigmentos orgânicos e aditivos. Com a popularização das tatuagens nos últimos anos, o número de relatos envolvendo reações aos pigmentos tem aumentado. Foram encontradas na literatura, reações alérgicas e/ou de hipersensibilidade atrasada aos pigmentos, incluindo relatos de casos sobre uveíte pós tatuagem, assim como a identificação da presença de níquel e cromo na pele de indivíduos tatuados em decorrência do estresse mecânico das agulhas utilizadas na técnica. Verificou-se também que a quebra de partículas de pigmentos por fotodecomposição pode ocasionar aumento na toxicidade. Considerações finais: Evidencia-se a necessidade de maior rigor na regulamentação e fiscalização desses corantes, bem como a criação de normas padronizadas de controle de qualidade para os pigmentos, métodos de identificação e quantificação dos compostos utilizados.
Abordagem geral da asma: uma revisão narrativa
Authors: Rodrigues Amanda Santos , Sobrinho Lâmia André , Ferreira Bianca Danielle , Mota Sarah Mendonça , Cardoso Isabela Coelho , Rahal Marcela Romano , Melchiori Bianca Ridolfi , Rossi Ana Laura de Lima , Moreira Lais Siqueira , Miura Felipe Kazuyoshi
Published: November 2021

Objetivo: Relatar de forma atualizada uma abordagem geral da asma. Revisão bibliográfica: A asma pode ser definida como uma condição causada por broncoconstrições episódicas e reversíveis, secundária a inflamação da via aérea, que pode ocorrer por vários fatores, como infecções, alérgenos ambientais e irritantes. É uma condição imunomediada, multifatorial que se apresenta com uma clínica bastante variada e complexa. A inflamação alérgica é comandada pelos linfócitos T auxiliares CD4 + (Th2), os quais secretam interleucina (IL)-4, IL-5 e IL-13. O diagnóstico é feito na presença de fatores de risco para a doença, sinais e sintomas respiratórios típicos de limitação aguda e reversível do fluxo de ar documentada por espirometria. Os medicamentos usados no tratamento do paciente asmático são divididos em dois grupos: os de alívio e os controladores. Como representantes dos fármacos de alívio têm os ß2 agonistas de curta duração, anticolinérgicos e corticosteroides sistêmicos, enquanto que os controladores são, principalmente, os ß2 agonistas de longa duração e os glicocorticoides inalatórios. Considerações finais: A asma é uma condição que repercute na vida diária do paciente. Sua fisiopatologia está relacionada à produção de citocinas inflamatórias que desencadeiam a crise asmática, que é classificada e tratada quando analisa-se quadro clínico e espirometria.
Achados ecocardiográficos na cardiomiopatia hipertrófica
Authors: Júnior José Lopes Cavalcante , Nobre Marlucia do Nascimento , Marques Anne Elizabeth Andrade Sadala , Salgado Andrea Machado , Gonçalves Marcelo Mello , Marinho Antônio Augusto de Souza , Miranda Hudson Laert Machado de
Published: November 2021

Objetivo: Demonstrar a importância da ecocardiografia transtorácica no diagnóstico e seguimento dos pacientes com cardiomiopatia hipertrófica. Revisão bibliográfica: A cardiomiopatia hipertrófica caracteriza-se por um espessamento miocárdico anormal na ausência de condições que o justifiquem, como por exemplo, hipertensão arterial sistêmica e estenose aórtica. Possui diferentes formas de apresentação, sendo a septal assimétrica a mais comum. Pode ocorrer em outras localizações menos frequentes como apical, concêntrica e no ventrículo direito. Alguns casos evoluem com obstrução da via de saída do ventrículo esquerdo, quando o gradiente de pico é superior a 30 mmHg no repouso e 50 mmHg no esforço ou após manobra de Valsalva. Insuficiência mitral, arritmias, disfunção diastólica e sistólica, são outras complicações que podem estar presentes. Considerações finais: A ecocardiografia transtorácica é o principal exame no diagnóstico desta patologia. Permite identificar e quantificar a gravidade da hipertrofia, suas complicações, além de fornecer importantes dados prognósticos quanto ao risco de morte súbita cardíaca.
Rare Mucosal Lip Atypical Fibroxanthoma Treated with Mohs Micrographic Surgery
Authors: Howard Tara , Matin Taraneh , Howard John , Howard Eduardo Weiss
Published: November 2021

Atypical fibroxanthoma (AFX) is a rare dermal neoplasm of low-intermediate malignant potential found almost exclusively in the non-mucosal regions of the head and neck in light-skinned elderly males who have a history of significant sun exposure.

Due to its risk of misdiagnosis of more common skin lesions and possibility of metastases, AFX requires resection with either Mohs Micrographic Surgery (MMS) or wide local excision (WLE). The purpose of this abstract is to discuss the best comprehensive treatment for a lower lip AFX using MMS versus WLE.
Cross-Sectional Survey of Students and Instructors on Virtual Dermatology Teaching in a Competency-based Format
Authors: Chopra Shara , Sinharoy Ankita , Flamm Alexandra
Published: November 2021

Background

Due to the COVID-19 pandemic in the Spring of 2020, the dermatology rotation at the Penn State College of Medicine was converted into a 4-week virtual format. Given these rapid changes, we aimed to assess student and instructor satisfaction to the virtual course and if the course fulfilled the six ACGME core-competencies for medical student education required in a traditional teaching format.

 

Methods

We conducted a cross-sectional study to assess PSCOM student and instructor satisfaction to the elective. Surveys specifically inquired about course learning objectives, interaction, and teaching in the virtual setting based on a 5-point Likert scale and asked to provide qualitative feedback.

 

Results

Medical students (n=15, response rate=52%) were satisfied with learning objectives geared towards the ACGME core competencies in five of the six competencies. Instructors (n=7, response rate=58%) reported satisfaction with convenience, university support, and technical training, but less with student-to-student interaction, gauging comprehension, and fostering critical thinking. Qualitative feedback reflected these results.

 

Conclusions

From our survey data, students and instructors were generally satisfied with the virtual rotation’s dermatology teaching during the uncertain times of the COVID-19 pandemic and holds potential to expand dermatology education, with a future focus on improving student engagement in a virtual format.
Dermatofibrosarcoma Protuberans Presenting as a Subcutaneous Cystic Nodule
Authors: Logas Chris , Dunn Austin , Lazarra Danielle , Rubin Justin , Saleeby Eli , Glick Brad
Published: November 2021

A 41-year-old African American male complains of a painful cyst located on his right shoulder and lasting 2 years. The specimen was excised and stained positive for CD34 and negative for SOX-10, confirming the diagnosis of Dermatofibrosarcoma Protuberans (DFSP). The initial specimen had positive extension at both the deep and lateral margins. Complete removal of the tumor required 3 stages of MMS resulting in a 10 cm x 7.6 cm final defect, extending to muscle. As demonstrated in this case, DFSP has an erratic growth pattern and requires meticulous histopathological examination to ensure clear margins. MMS is the preferred method of treatment. Cases of DFSP have high rates of recurrence and require regular follow-up for 3-5 years after treatment.
Willingness of Patients from an Urban Safety-Net Dermatology Clinic to Receive a COVID-19 Vaccine
Authors: Mumber Hannah , Del Campo Daniela , Alvarado Manuel , Watchmaker Jacqueline
Published: November 2021

Background: While recent vaccine development has initiated a return to pre-COVID "normalcy" both in the dermatology clinic and worldwide, significant challenges remain regarding the public’s willingness to receive a COVID-19 vaccine. Dermatologists often discuss vaccinations with their patients and aid them in making evidence-based medical decisions. Previous studies have looked at the U.S. population’s willingness to receive a COVID-19 vaccine, but no studies have examined the dermatology patient population from an urban, safety-net hospital. Studies have shown that understanding the target audience is the first step towards increasing vaccine acceptance.
Methods: A cross-sectional, telephone-based survey study was administered to 326 patients of an urban, safety-net hospital from July 2020 to August 2020 in order to assess willingness to obtain a COVID-19 vaccine.
Results: Our survey study showed that 57.7% of patients with a recent dermatology appointment are willing to receive a COVID-19 vaccine and that safety concerns represent the main reason for patient hesitancy. Patients who do not regularly receive a flu vaccine, non-Caucasian patients, and those who know someone who tested positive for COVID-19 are less willing to receive a COVID-19 vaccine. Patients with a recent dermatology appointment are more willing to receive a COVID-19 vaccine than those who did not have a recent dermatology appointment.
Conclusions: Our results provide dermatologists, especially those working in urban safety-net clinics, with key information about the attitude of patients toward the COVID-19 vaccine.
Efficacy of Brodalumab vs Ustekinumab by Prior TNFα Inhibitor Exposure: Post hoc Analysis of Two Phase 3 Psoriasis Studies
Authors: Menter Alan , Boh Erin , Lewitt George , Jacobson Abby
Published: November 2021

N/A
Neutralizing interleukin-13 increases skin microbial diversity: results from a Phase 3, randomized, double-blind, placebo-controlled trial of tralokinumab in adult patients with atopic dermatitis
Authors: Bieber Thomas , Beck Lisa , Pink Andrew , Saeki Hidehisa , Eichenfeld Lawrence , Werfel Thomas , Rosholm Anders , Ropke Mads , Paller Amy
Published: November 2021

N/A
Improvements in Acne and Skin Oiliness with Tazarotene 0.045% Lotion in Acne Patients with Oily Skin
Authors: Tanghetti Emil , Gold Michael , Sadick Neil , Cook-Bolden Fran , Kircik Leon , Stein Gold Linda , Tyring Stephen , Del Rosso James , Guenin Eric
Published: November 2021

N/A
Oral Sarecycline for Treatment of Papulopustular Rosacea: Results of a Pilot Study Evaluating Efficacy and Safety
Authors: Del Rosso James , Kircik Leon , Effron Cheryl , Draelos Zoe
Published: November 2021

N/A
Quantifying Uptake of Eye Serum After 1440-nm or 1927-nm Non-ablative Fractional Diode Laser Treatment
Authors: Wang Jordan , Friedman Paul , Konda Adarsh , Parker Catherine , Geronemus Roy
Published: November 2021

N/A
CASE OF SECONDARY THROMBOTIC THROMBOCYTOPENIC PURPURA TRIGGERED BY COVID-19
Authors:   Grodno State Medical University, Grodno, Belarus, Yakubtsevich R. E. , Zukhovitskaya Ye. V. ,   Grodno State Medical University, Grodno, Belarus, Dorokhin K. M. ,   Grodno State Medical University, Grodno, Belarus, Vasilevskaya N. F. ,   Grodno State Medical University, Grodno, Belarus
Published: November 2021

The article analyzes a clinical case of the development of thrombotic thrombocytopenic purpura (TTP) in a patient with verified COVID-19 infection. The algorithm of TTP diagnosis when ADAMTS13 biomarker test is unavailable is presented. The article presents the scheme of effective treatment of TTP with the use of plasma exchange, methylprednisolone and rituximab administration.
FEATURES OF DIAGNOSIS AND TREATMENT OF ILIOPSOITIS IN A PATIENT WITH DIABETES MELLITUS. CLINICAL CASE
Authors:   Grodno State Medical University, Grodno, Belarus, Nikonova L. V. , Tishkovskiy S. V. ,   Grodno State Medical University, Grodno, Belarus, Davydchik E. V. ,   Grodno State Medical University, Grodno, Belarus, Martinkevich O. N. ,   Grodno University Clinic, Grodno, Belarus, Volkova E. T. ,   Grodno University Clinic, Grodno, Belarus, Shidlovskaya О. А. ,   Oshmiany Central District Hospital, Oshmiany, Belarus
Published: November 2021

A clinical case of iliopsoitis detected during hospitalization in the endocrinology department of the Healthcare Institution "Grodno University Clinic" is presented. The article describes the tactics of examination and successful treatment of iliopsoitis in a patient with diabetes mellitus and SARS-CoV-2.
ENDOSCOPIC TECHNOLOGIES IN THYROID SURGERY: INTERNATIONAL AND OWN EXPERIENCE
Authors:   Brest Regional Clinical Hospital, Brest, Belarus, Radievski I. L. , Danilova L. I. ,   Belarusian Medical Academy of Postgraduate Education, Minsk, Belarus
Published: November 2021

Topicality. With the development of endoscopic technology, minimally invasive interventions on the thyroid gland have been widely developed. The introduction of minimally invasive techniques into practice is associated with the desire to improve the cosmetic effect and reduce surgical trauma for patients. The aim: to study the most popular techniques used in minimally invasive thyroid surgery, to show the advantages and disadvantages of each technique, the likelihood of one or another postoperative complication depending on the method of surgical intervention on the thyroid gland. Material and methods: Among minimally invasive interventions, mini-approaches have become widespread: axillary, anterior thoracic, paraareolar, posterior, transoral. When performing video-assisted surgical interventions, an endoscopic stand, a standard set of instruments (clamps and scissors for endoscopic operations), retractors for creating an operating space are used. Results: Criteria for a differentiated approach to the choice of the method of minimally invasive surgical intervention on the thyroid gland have been substantiated. The main task when choosing a method of surgical intervention is its simplicity, the possibility of rapid development, economic efficiency, and safety. Conclusions: Ensuring the safety and correct technique of performing surgery with mandatory monitoring of the recurrent nerve, visualization of the parathyroid glands made it possible to obtain good clinical results in patients with this pathology.
Analisis Kebutuhan Penyediaan Air Bersih di Kota Palembang City
Authors: Kurniawan M. Agung , Fitriani Heni , Hadinata Febrian
Published: November 2021

[ID] Cakupan pelayanan air bersih di Kota Palembang pada tahun 2020 sebesar 83,22%, sehingga masih ada 16,78% penduduk Kota Palembang yang belum dapat terlayani. Kondisi tersebut akan semakin memburuk seiring bertambahnya kebutuhan air tiap tahunnya. Penelitian ini bertujuan untuk mengetahui cakupan pelayanan, kebutuhan air maksimum dan neraca air, sehingga diharapkan dapat menjawab persoalan yang akan dibahas. Penelitian dimulai dengan melakukan proyeksi penduduk dan proyeksi pelanggan. Hasil proyeksi akan menghasilkan proyeksi cakupan pelayanan. Perhitungan kebutuhan air didapatkan dari kebutuhan dari jumlan pelanggan yang telah diproyeksikan. Selanjutnya proyeksi kebutuhan air akan dihubungkan dengan rencana penambahan kapasitas produksi sehingga menghasilkan neraca air. Hasil penelitian menunjukkan bahwa pada tahun 2021 dan tahun selanjutnya diproyeksikan cakupan pelayanan akan mengalami perbaikan dan pada tahun 2030 pelayanan air bersih 100% Kota Palembang dapat tercapai. Kebutuhan air pada tahun 2021 sebesar 4.875 lps dan semakin meningkat pada tahun berikutnya hingga pada tahun 2033 kebutuhan air mencapai 7.146 lps. Kondisi neraca air juga diproyeksikan akan mengalami perbaikan, dimana pada tahun 2020 masih mengalami defisit kapasitas sebesar 257 lps dan pada tahun berikutnya hingga tahun 2031 dapat mempertahankan surplus kapasitas.

[EN] The coverage of clean water services in Palembang City in 2020 is 83.22%, so there are still 16.78% of the population of Palembang City who have not been served. This condition will worsen as the demand for water increases every year. This study aims to determine service coverage, maximum water demand and water balance, so that it is expected to be able to answer the issues to be discussed. The research begins by conducting population projections and customer projections. The projection results will produce a projection of service coverage. The calculation of water needs is obtained from the needs of the projected number of customers. Furthermore, the projected water demand will be linked to the plan to increase production capacity so as to produce a water balance. The results of the study show that in 2021 and the following year it is projected that service coverage will improve and in 2030 100% clean water services for Palembang City can be achieved. The need for water in 2021 is 4,875 lps and will increase in the following year until in 2033 the water needs will reach 7,146 lps. The condition of the water balance is also projected to improve, where in 2020 it will still experience a capacity deficit of 257 lps and in the following year until 2031 it can maintain a capacity surplus.
La seguridad de la información en la administración pública
Authors: Altamirano-de-la-Borda Kadú Josep
Published: November 2021

La información pública es producto de la administración y transformación de otra información que tiene un efecto directo en la ciudadanía, por lo cual debe ser protegi da asegurando su confidencialidad, integridad y disponibilidad, teniendo siempre presentes los principios del derecho al acceso a la información de los ciudadanos. Si bien en el Perú se han dado los pasos adecuados para implementar los sistemas de gestión de seguridad de la información en el ámbito público, solo el 6 % de los organismos públicos ha cumplido con implementar lo dispuesto por la normativa vigente. Por lo cual se hace necesario que el Estado redoble los esfuerzos para proteger su información a través de la implementación de sus siste mas de gestión de seguridad de la información, ya que los nuevos escenarios referentes a la tecnología, la información y la interacción entre Estado y ciudadanía así lo requieren.
Detección del SARS-CoV-2 en radiografías de tórax por medio de descriptores intermedios y técnicas de machine learning
Authors: Bardález-Trigoso Gonzalo , Bazán-Arzapalo Jean Pablo , Fabián Junior , Montenegro-Montori Pedro
Published: November 2021

El SARS-CoV-2, que causa la enfermedad del COVID-19, es un virus que se ha expandido rápidamente por el mundo, teniendo como lugar de inicio la ciudad de Wuhan, en China. A la fecha se han detectado más de 36 738 525 casos a nivel mundial. La tasa de infectados aumenta diariamente y la capacidad sanitaria no se da abasto. Por estas razones, se ha venido proponiendo una variedad de métodos para identificar el novel coronavirus con mayor rapidez y a menor costo. Un ejemplo de estos métodos para identificar la enfermedad es el COVID-Net, una red convolucional que identifica el COVID-19, neumonía o pulmones en condición normal. En este trabajo se propone una metodología para identificar y clasifi car imágenes de radiografías de tórax que tienen el COVID-19, neumonía o sin condición. Para esto se utilizaron extractores de características intermedias: HOG+PCA, SIFT+K-means y SURF+K-means, combinados con un SVM como clasificador; además, se emplearon tres estructuras CNN: VGG19, Densenet121 y MobilnetV2. Se utilizó la base de datos COVIDx3 que consta de 15 476 imágenes radiográficas de pulmón. Se obtuvieron buenos resultados, y se determinó que la mejor de las combinaciones fue la que utilizó MobilnetV2 con aumento de datos obteniendo una sensitividad por clase COVID-19 de 0,97 y en promedio una precisión y sensitividad de 0,92 y 0,91. Debido al contexto de la crisis sanitaria generada por el COVID-19, este trabajo se presenta como un apoyo para la detección de esta enfermedad y como marco de referencia para futuras investigaciones.
Criterios para la configuración de plataformas de inteligencia aumentada para el mejoramiento de la sostenibilidad de cultivos agrícolas
Authors: Peña-Palacio Alejandro
Published: November 2021

El desarrollo de la inteligencia artificial ha planteado una serie de retos en cuanto al futuro y la sostenibilidad del trabajo humano. Sin embargo, el desarrollo de la tecnología ha traído consigo el desarrollo de conceptos como el de la inteligencia aumentada (IA), el cual tiene por objetivo el mejoramiento de las capacidades humanas mediante la interacción hombre-máquina para la solución de problemas complejos en diferentes áreas del conoci miento. Esta interacción supone una serie de retos desde lo tecnológico, ya que la experiencia humana es un proceso complejo de transfer learning para que las máquinas sean un comple mento perfecto de las personas. En el contexto de la agricultura de precisión, las plataformas de inteligencia aumentada (AIP, por sus siglas en inglés) han surgido como una alternativa importante para el fortalecimiento de las capacidades en la detección y diagnóstico de estados fitosanitarios o agroclimáticos. En este artículo, se propone una metodología para la configu ración de las AIP, integrando tres elementos que son fundamentales para la sostenibilidad de cultivos como son: imágenes áreas espectrales utilizando vehículos aéreos no tripulados (UAV, por sus siglas en inglés), mapas de pronóstico para describir la dispersión de enfermedades y sus vectores asociados en campo, modelos deep y machine learning para la caracterización auto mática de eventos fitosanitarios o agroclimáticos, así como redes IoT-IoB (Internet of Things e Internet of Beings) para la interacción hombre-dispositivos. Para la evaluación de estas platafor mas, se propone un GAP de sostenibilidad, el cual evalúa de una manera integral la reducción en el uso de pesticidas y fertilizantes, así como la sostenibilidad de los puestos de trabajo en un futuro de largo plazo, y en donde la inteligencia artificial tendrá un papel preponderante en el desarrollo agrícola en el mundo.
Videojuegos educativos enfocados a la enseñanza de ciberseguridad para estudiantes escolares
Authors: Plácido-Morales Miguel Antonio
Published: November 2021

La navegación en internet se ha tornado más insegura para todos con el paso de los años, pero distintas investigaciones en el mundo y en Latinoamérica han evidenciado que dentro de este panorama los jóvenes son objetivos más vulnerables para los atacantes en la red. En nuestro país esto es una realidad que puede ser combatida con el uso de métodos educativos modernos, como los videojuegos.