bluuebunny/crossref_metadata_2025 huggingface dataset:
Syntheses and Crystal Structures of Copper Complexes of the Imidazole Ligand
Authors: Wu Wen , Xie Jimin , Xuan Yawen
Published: December 2009

Two copper(II) complexes, [Cu(im)6]Cl2·4H2O (1), and [Cu(im)6]Cl2·2H2O (2) (im = imidazole), have been synthesised. In compound 1, [Cu(im)6]2+cations and Cl- counter anions alternately array in an ABAB fashion via N-H…Cl hydrogen bonding. There are two kinds of hydrogen bonds, inter- and intramolecular hydrogen bonding interactions, which form 2-D sheets. However, an interesting polymeric network is formed from the weak intermolecular interactions in compound 2.
A New Leaving Group in Nucleophilic Aromatic Substitution Reactions (SNAr)
Authors: Bakavoli Mehdi , Pordel Mehdi , Rahimizadeh Mohammad , Jahandari Pooneh
Published: December 2009

Nucleophilic aromatic substitution of a 2,4-dinitrophenyl substituted pyrazole 1 with primary amines leads to substitution of the pyrazolo substituent. In these nucleophilic aromatic substitution reactions (SNAr), 5-amino-1 H-4-pyrazolecarbonitrile (3) acts as a new leaving group.
Synthesis of Tetrasubstituted Olefins by Stereoselective Allylzincation-Negishi Tandem Reaction of Acetylenic Sulfones
Authors: Li Jianying , You Shengyong , Cai Mingzhong
Published: December 2009

Tetrasubstituted olefins containing a 1,3,6-triene structural unit can be regio- and stereoselectively synthesised in good yields under mild conditions in one pot, by allylzincation-Negishi tandem reaction of acetylenic sulfones with allylzinc bromide and alkenyl halides.
2-Aryl-4-chloro-3-iodoquinolines as Substrates for the Synthesis of 2,3-diaryl-4-methoxyquinolines
Authors: Mphahlele Malose J. , Mtshemla Vathiswa
Published: December 2009

Sequential functionalisation of 2-aryl-4-chloro-3-iodoquinolines via palladium–catalysed cross-coupling with phenylboronic acid followed by displacement of the 4-chloro atom from the resulting 2,3-diaryl-4-chloroquinolines with methoxide ion yielded 2,3-diaryl-4-methoxyquinolines. The latter were also prepared via Suzuki–Miyaura cross-coupling of 2-aryl-3-iodo-4-methoxyquinolines with phenylboronic acid. Demethylation of the methoxy compounds (BBr3) gave the 2,3-diaryl-4(1 H)-quinolinones.
Synthesis and Tautomeric Structure of 3,6-bis(arylazo)pyrazolo [1,5-a]pyrimidine-5,7(4H,6H)-diones
Authors: Shawali Ahmad S. , Mosselhi Mosselhi A. N. , Farghaly Thoraya A. , Shehata Mohamed R. , Tawfik Nagla M.
Published: December 2009

Two series of 3,6- bis(arylazo)pyrazolo[1,5- a]pyrimidine-5,7-diones were prepared, and their acid dissociation constant pKas were determined and correlated with the Hammett equation. The results of these correlations, together with the spectroscopic data, indicated that the title compounds exist predominantly in the 3-arylazo-6-arylhydrazonopyrazolo[1,5- a]pyrimidine-5,7-dione tautomeric form, both in the solid and solution phases.
Octakis (9-anthracenylmethylthio) Iron Porphyrazine Derivatives
Authors: Gonca Ergün
Published: December 2009

Chloro[octakis(9-anthracenylmethylthio)porphyrazinato]iron(III), ([FePzCl]), was prepared by the reaction of metal-free porphyrazine with iron(II) acetate and further treatment with HCl solution. The monomeric bisaxial complex [FePz(py)2] as well as the bridged complex [FePz(pyz)] n were formed as stable complexes by reacting [FePzCl] with pyridine or pyrazine, respectively. These novel complexes were characterised by elemental analysis, together with FT-IR, 1H NMR, UV-Vis and mass spectral data.
Microwave Reaction of Diazonium Salts with Nitriles
Authors: Saez Rebeca , Otero M. Dolores , Batanero Belen , Barba Fructuoso
Published: December 2009

A series of aryldiazonium tetrafluorborates dissolved in nitriles have been converted into the corresponding anilides in almost quantitative yield in 1 min by microwave irradiation. When bromoacetonitrile was used, 2,4-bis(bromophenyl)-quinazoline was formed. The reaction of malononitrile with the diazonium salt, in DMF as a solvent, afforded 2-(dimethylaminomethylene) malononitrile and phenylhydrazone propanedinitrile.
Application of N-Nitrosoureas in the Synthesis of Organophosphorus Compounds
Authors: Afshar Davood Aghaei , Islami Mohammad Reza
Published: December 2009

N-nitrosoureas which are readily accessible from the reaction of urea derivatives with sodium nitrite and aqueous H2SO4 reacted with acetylenic esters in the presence of Ph3P in ethyl acetate at ambient pressure to give stable phosphorus ylides. This methodology is introduced as a simple and inexpensive procedure for the preparation of organophosphorus compounds in excellent yields.
A New Ent-Kaurane Diterpenoid from Isodon Nervosus
Authors: Yan FuLin , Wang ChunMing , Guo LanQing , Zhang JiXia , Bai SuPing
Published: December 2009

A new ent-kaurane diterpenoid, 6β,7β,13α-trihydroxy-1α-acetoxy-7α,20-epoxy- ent-kaur-16-en-15-one (1) and five known compounds, epinodosinol (2), isodocarpin (3), nodosin (4), enmedol (5), nervosanin B (6), were isolated from the aerial part of Isodon nervosus. The structure of the new compound was determined by spectral methods (1D-,2D-NMR and MS). Four of the compounds were tested for their cytotoxicity towards HL60, SMMC-7721 and Hela cells.
An Aerobic Ligandless Palladium Acetate Catalysed Suzuki-Miyaura Cross-Coupling Reaction in an Aqueous Solvent
Authors: Li Chen , Li Xiao-Qiang , Zhang Chi
Published: December 2009

The Suzuki–Miyaura reaction of aryl iodides and aryl bromides was catalysed by Pd(OAc)2 (1 mol%) using K3PO4·3H2O (2 equiv) as base in dimethyl acetamide DMA-H2O (1 : 1) at room temperature. Changes in the loading of Pd(OAc)2 (from 1 mol% to 2 mol%), temperature (from room temperature to 80 °C) and the ratio of DMA to water (from 1 : 1 to 5 : 1) resulted in the successful coupling of activated aryl chlorides with phenylboronic acid.
One-Pot Synthesis of α-Aminophosphonates on Silica under Solvent-Free Conditions from Aromatic Aldehydes
Authors: Wu Ming Shu , Zhang Xiang Zhu
Published: December 2009

α-Aminophosphonates were synthesised under solvent-free conditions on an acidic silica gel support using aromatic aldehydes, diethyl phosphite and anhydrous ammonium acetate as starting materials in moderate yields
Preparation and Crystal Structure of Genistein Benzenesulfonate Prodrugs
Authors: Peng You , Deng Zeyuan , Lang Shaojie , Fan Yawei
Published: December 2009

In order to improve bioavailability and anticancer activity of genistein, a series of novel sulfonic acid ester prodrugs of the isoflavone genistein were synthesised in high yield with excellent regioselectivity. Their structures were characterised by IR, MS, elemental analysis and 1H NMR spectra. The crystal structure was examined by X-ray diffraction. X-ray structure determination revealed that all the aromatic rings in the compound are not coplanar. In the crystal structure, molecules are linked through intermolecular C-H···O hydrogen bonds, forming layers parallel to the ab plane.
One-Pot Synthesis of Substituted 2-Amino-3-Furonitriles
Authors: Bakavoli Mehdi , Rahimizadeh Mohammad , Gordi Zinat
Published: December 2009

Solvent-free reaction of substituted α-haloketones with malononitrile in the presence of diethylamine provides an efficient one-pot synthesis of 2-amino-5-aryl (alkyl)-3-furonitriles in high yield.
Organic Photochromic Radical Compound Based on a Biindenylidene System
Authors: Li Xu
Published: December 2009

A novel dual functional biindenylidene derivative (4) having nitronyl nitroxide radicals on both sides of the molecules, was synthesised. Its photochromism, as well as magnetic properties were investigated. The compound 4 underwent photochromic reactions by irradiation with UV and visible light. The intermolecular magnetic interactions were measured with a SQUID susceptometer.
Synthesis of terminal arylacetylenes by a Stille coupling reaction catalysed by a MCM-41-supported bidentate phosphine palladium(O) complex
Authors: Hao Wenyan , Wang Yue , Sheng Shouri , Cai Mingzhong
Published: December 2009

A variety of terminal arylacetylenes have been conveniently synthesised in good to high yields by Stille coupling of aryl halides with ethynyltributylstannane catalysed by a MCM-41-supported bidentate phosphine palladium(O) complex in an aqueous medium and under air. Our system not only avoids the requirement for water-free and oxygen-free conditions, but also solves the basic problem of palladium catalyst reuse.
New triterpenoids from the leaves of Photinia serrulata
Authors: Yang Li-Bing , Zhao Li-Xing
Published: December 2009

A new triterpenoid, 3β,15α-dihydroxy-12-keto-9(11)-ursene, and three known analogues, were isolated from the leaves of Photinia serrulata. The structure of the new compound, including its relative configuration, was elucidated by spectroscopic analysis, especially by two dimensional NMR techniques.
Synthesis and reactions of indeno[1,2-c]chromene-6,11-dione derivatives
Authors: Mahmoud Mahmoud R. , El-Shahawi Manal M. , El-Bordany Eman A.A. , El-Azm Fatma S.M. Abu
Published: December 2009

Indeno[1,2-c]chromene-6,11-dione was prepared using the readily obtainable starting materials via the condensation of dimethyl homophthalate with 2,6-dichlorobenzaldehyde in the presence of sodium hydride in dry benzene followed by saponification and cyclisation with concentrated sulfuric acid at 0°C. The tendency of indeno[1,2-c]chromene-6,11-dione for undergoing nucleophilic addition has been tested by reaction with nitrogen nucleophiles such as hydrazine hydrate, hydroxylamine hydrochloride, ethyl carbazate, cyanoacetic acid hydrazide, thiosemicarbazide and 4-methylbenzenesulfonohydrazide. The IR, 1H NMR, 13C NMR and mass spectra of the synthesised compounds are discussed.
Syntheses of Pyrazolo-, Isoxazolo-, Pyrido- and Pyrimido-Carbazoles from 2-(3′,4′-Dimethoxybenzylidene)-2,3,4,9-Tetrahydrocarbazol-1-Ones
Authors: Sridharan Makuteswaran , Beagle Lucas K. , Zeller Matthias , Prasad Karnam Jayarampillai Rajendra
Published: December 2009

Mixed aldol condensation of 2,3,4,9-tetrahydrocarbazol-1-ones with 3,4-dimethoxybenzaldehyde (veratraldehyde) yielded 2-(3′,4′-dimethoxybenzylidene)-2,3,4,9-tetrahydrocarbazol-1-ones. These enones on reaction with hydrazine hydrate, hydroxylamine hydrochloride, malononitrile and guanidinium nitrate under different conditions yielded the corresponding pyrazolo[3,4-a]-, isoxazolo[3,4-a]-, pyrido[2,3-a]-, and pyrimido[4,5-a]-carbazoles respectively. The molecular and crystal structure of 2-(3′,4′-dimethoxybenzylidene)-2,3,4,9-tetrahydro-1H-carbazol-1-one resolved by single crystal X-ray diffraction is discussed.
Synthesis of a Novel Heterocyclic Ring System: Imidazo[3,2-D] [1,2,4]Triazolo[3,4-B][1,3,4]Thiadiazine
Authors: Bakherad Mohammad , Keley Vahid , Amin Amir H.
Published: December 2009

Synthesis of the novel compounds 3-substituted-6-arylimidazo[3,2-d][1,2,4]triazolo[3,4-b][1,3,4]thiadiazines was achieved by the reaction of 6-amino-3-substituted-7H-[1,2,4]triazolo[3,4-jb][1,3,4]thiadiazines with 4-substituted-phenacyl bromides in refluxing ethanol.
A convenient synthesis of CF3-containing alkynyl imines by a copper-free Sonogashira coupling of imidoyl chlorides with terminal alkynes
Authors: Chen Muwang , Zhang Qiaochu , Zhang Xingguo , Zhong Ping , Hu Maolin
Published: December 2009

A series of N-aryltrifluoroacetimidoyl chlorides and 1-alkynes were converted into α-imino alkynes by a Sonogashira reaction using Pd(PPh3)4/DABCO as the catalyst. The reaction proceeded smoothly to give the coupled products in good to excellent yields.
Facile synthesis of fused quinolines via intramolecular Friedel–Crafts acylation
Authors: Li Yang , Chang Ming-qin , Gao Feng , Gao Wen-tao
Published: December 2009

The intramolecular cyclisation of 6-[(phenoxy/phenylthio)methyl][1,3]dioxolo[4,5-g]quinoline-7-carboxylic acids to [1]benzoxepino[3,4-b][1,3]dioxolo[4,5-g]quinolin-12(6H)-onesand[1]benzothiepino[3,4-b][1,3]dioxolo[4,5-g]quinolin-12(6H)-ones in the presence of Eaton's reagent (P2O5-MeSO3H) is described. This cyclisation protocol requires milder conditions than those traditionally employed and is characterised by relatively low reaction temperatures and ease of product isolation.
Two new ceramides from the radix of Angelica sinensis
Authors: Lü Jie-Li , Duan Jin-Ao , Tang Yu-Ping , Ge Yue-Lan
Published: December 2009

Phytochemical investigation of the radix of Angelica sinensis has led to the isolation two new ceramides, angelicamide A (1) and B (2), along with one known ceramide, (2S, 3S, 4R, 8E)-2-[(2′R)-2′-hydroxytetracosanoyl]-8-octadecene-1,3,4-triol (3). Their structures were determined by spectroscopic methods including IR, NMR (1D and 2D NMR) and MS. This is the first report on the occurrence of ceramides in the Angelica genus.
Two new oleanane triterpene glycosides from Gymnema inodorum
Authors: Wang Dingyong , Li Guocheng , Feng Yujing , Xu Suying
Published: December 2009

Two new oleanane triterpene glycosides were isolated from the n-BuOH extract of Gymnema inodorum. On the basis of spectroscopic evidences, their structures were elucidated as 2α, 3β-dihydroxy-olean-12-ene-23, 28-dioic acid-3-O-β-D-glucopyrano-side and 2α, 3β, 15β-trihydroxy-olean-12-ene-23, 28-dioic acid-3-O-β-D-gluco-pyranoside.
Improved synthesis of 6-(4-methoxyphenyl)-2,4-dichloro-1,3,5-triazine and 2,4-bis(resorcinyl)-substituted UV light absorbing derivatives
Authors: Jiang Wen-Feng , Wang Hui-Long , Li Zhe-Qi
Published: December 2009

Pure 6-(4-methoxyphenyl)-2,4-dichloro-1,3,5-triazine was synthesised by a method that did not involve the troublesome Grignard reaction of 4-bromo-anisole. A series of bis(resorcinyl) triazine derivatives which can be used as UV light absorbers were subsequently prepared by utilising 6-(4-methoxyphenyl)-2,4-dichloro-1,3,5-triazine as the starting material via alkylation or acid-catalysed addition reactions.
A facile one-pot Friedländer synthesis of quinoline derivatives
Authors: Reddy P. Prabhakar , Raju B. China , Rao J. Madhusudana
Published: December 2009

A facile one-pot Friedländer synthesis has been developed for quinolines using GdCl3.6H2O as the novel catalyst. The method is simple, efficient and rapid to afford the quinolines in very good yields.
Formation of 5-alkylidenepyrazol-4(1H)-ones and 3-amino-6-aryl-5-cyano-pyridazine-4-carboxylates from arenealdehyde thiosemicarbazones and unsaturated 1,2-diesters
Authors: Hassan Alaa A. , Shehata Hamdy S. , Döpp Dietrich
Published: December 2009

The reaction of arenealdehyde 4-phenylthiosemicarbazones 1a–f with dimethyl ethynedicarboxylate (6) gave methyl [3-aryl-4-oxo-1-(phenylthiocarbamoyl)-4,5-dihydro-1H-pyrazol-5-ylidene]ethanoates 10a–f in 73-79% yield, while, by reaction with diethyl (E)-2,3-dicyanobutenedioate (7), compounds 1a–f are transformed into ethyl [3-aryl-4-oxo-1-(phenylthiocarbamoyl)-4,5-dihydro-1H-pyrazol-5-ylidene]cyanoacetates 15a–f (54-61%) and ethyl 3-amino-6-aryl-5-cyanopyridazine-4-carboxylates 24a–f (22-26%). Rationales for these transformations are presented.
Proline triflate catalysed Diels–Alder reaction in the synthesis of tetrahydroquinoline derivatives
Authors: Li Jianjun , Li Jia , Su Weike
Published: December 2009

Proline triflate was found to catalyse efficiently the one-pot synthesis of 2H-pyranotetrahydroquinolines from aryl imines, and 3,4-dihydro-2 H-pyran with high stereoselectivity. The aryl imines were formed in situ from aromatic amines and arylaldehydes.
Facile synthesis of amide and amine derivatives of 2,2,3,3-tetramethylcyclopropanecarboxylic acid
Authors: Wang Hui-Long , Jiang Wen-Feng , Li Zhe-Qi
Published: December 2009

An efficient one-pot procedure for the synthesis of amide derivatives of 2,2,3,3-tetramethylpropanecarboxylic acid (TMCA) that involves the treating of TMCA in N,N-dimethylacetamide (DMAC) with thionyl chloride and stoichiometric amounts of reactant amines has been developed. The combined reagent TiCl4/NaBH4 was found to be effective for the reduction of the amide derivatives of TMCA to the corresponding amines.
Synthesis, characterisation and activity in catalytic epoxidation of olefins of new dinuclear nickel(ll) complexes
Authors: Bera Manindranath
Published: December 2009

Two new dinuclear nickel(ll) compounds of formula [Nill2(μ-L1)2](CIO4)2·MeCN (1·MeCN) and [NiII2(μ-L2)2](CIO4)2 (2) where HL1 and HL2 stand for 3-(2-(dimethylamino)ethylimino)butan-2-one oxime and 1-(2-(dimethylamino)ethyl-imino)-1-phenylpropan-2-one oxime respectively, have been synthesised. Single crystal X-ray analyses of the complexes reveal that the nickel(ll) ions are in square-planar N3O environments and form six-membered (NiNO)2 metallacycles. Cyclic voltammetric measurements of 1·MeCN and 2 in MeCN solution show quasirreversible one-electron oxidations at E1/2 = 0.566 V and 0.603 V ( vs Fc+/Fc), respectively, attributed to NiIIINiII/NiII2 redox couples. Additional reversible NiIII2/NiIIINiII redox responses were observed at relatively higher potential near E1/2 = 0.832 V and 0.850 V ( vs Fc+/Fc), respectively, for 1·MeCN and 2. Complexes 1·MeCN and 2 display intense charge-transfer bands at ∼390 and ∼345 nm in the visible region. Chemical oxidation of complex 1·MeCN by sodium hexachloroiridate(IV) hexahydrate generates red Ni2III species with characteristic new bands at ∼520 and 427 nm in the visible region as well as the characteristic EPR signals at 77 K with g⊥ > gII. Similar phenomena were observed for complex 2 upon chemical oxidation. The dinickel(ll) complexes are catalytically active for epoxidation of olefins using iodosylbenzene as the terminal oxidant.
Solid-state Synthesis and Crystal Structure of a Novel Quaternary Metal Chalcogenide
Authors: Kuang Han-Mao , Chen Wen-Tong , Chen Hua-Long , Ying Shao-Ming
Published: December 2009

An unprecedented quaternary metal chalcogenide hg3Zn2S4I2 (1) has been obtained by solid-state reaction and structurally characterised by X-ray diffraction. Compound 1 crystallises in the space group C2221 of the orthorhombic system with four formula units in a cell: a = 12.571(4), b = 7.258(3), c = 10.742(4) Å, V = 980.1(6) Å3, Hg3I2S4Zn2, M r = 1114.55, D c = 7.553 g cm−3, T = 123.15 K, F(000) = 1880 and R1/ wR2 = 0.0636/0.1658 for 542 observed reflections ( I > 2σ( I)) and 572 unique reflections. Compound 1 is characterised by a novel 3-D framework motif.
Copper(I) complex of 2,2′-biquinoline assembled by non-covalent interactions
Authors: Li Tao , Chen Jie-bo , Wu Lei-Jiang , Lin Min , Huang Biao
Published: December 2009

A new 3-D supramolecular Cu(I) complex, [Cu(biq)CI] (biq = 2,2′-biquinoline), (1), has been synthesised and characterised. Single-crystal analysis shows that 1 contains 2-D layers linked by C–H…Cl interactions and the copper centres adopts a distorted trigonal planar geometry. Moreover there are π–π interactions between aromatic rings of the ligands, which connect the layers to form a 3-D supramolecular network.
Raney Ni–Al alloy-mediated reduction of benzils in water
Authors: Liu Guo-Bin , Zhao Hong-Yun , Dai Lu , Thiemann Thies , Tashiro Hideki , Tashiro Masashi
Published: December 2009

Raney Ni–AI alloy in a dilute aqueous alkaline solution has been shown to be a powerful reducing agent and is highly effective for the reduction of alkylbenzils and alkoxybenzils to afford the corresponding 1,2-diarylethers at 90°C, in the absence of organic solvents. 4,4′-Dinitrobenzil was transformed selectively to 1,2-bis(4-aminophenyl)-ethane.
Ligand-free copper-catalysed coupling reaction of heteroaryl bromides with imidazole and benzimidazole
Authors: Wu Xiang-Mei , Wang Yan
Published: December 2009

The synthesis of N-heteroarylimidazoles by coupling heteroaryl bromides with imidazole or benzimidazole under relatively mild conditions using the stable and readily available copper(II) acetate as catalyst and cesium carbonate as base is reported to give products in moderate to good yields.
Synthesis and antimicrobial activities of pyrano[3,2-c]quinoline, pyrimido [5′,4′:5,6]pyrano[3,2-c]quinoline and [1,2,4]triazolo[2″,3″:1′,6′]pyrimido [5′,4′:5,6]pyrano[3,2-c]quinoline derivatives
Authors: Mariah Fatma El
Published: December 2009

The synthesis of novel 7-(4-chlorophenyl)-6-hydroxy-3-methoxy-10-methyl-8,9-dihydro-7 H-pyrimido[5′, 4′: 5, 6]pyrano-[3,2- c]quinoline and [1,2,4]triazolo[2″,3″: 1′, 6′]pyrimido[5′, 4′: 5,6]pyrano[3,2- c]quinoline derivatives has been reported. The key intermediate 2-amino-4-(4-chlorophenyl)-5-hydroxy-8-methoxy-4H-pyrano[3, 2- c]-quinoline-3-carbonitrile was obtained by treating 4-hydroxy-7-methoxyquinolin-2(1 H)-one with various substituted α-cyanocinnamonitrile in ethanolic piperidine solution. Antimicrobial activity was shown for most of the synthesised compounds.
A facile synthesis and heteroannulation of pyrido[2,3-d]pyrimidine and related heterocyclic systems
Authors: Mahmoud M.R. , Shalaby A.A. , Gad T.A. , El-Khamry A.A.
Published: December 2009

7-Amino-1,2,3,4-tetrahydro-4-oxo-2-thioxo-5-(3,4,5-trimethoxyphenyl)pyrido[2,3- d]pyrimidine (1) was prepared and reacted with methyl iodide and ethyl chloroacetate to give the S-alkylated products 2 and 3, respectively. The reaction of 1 or 3 with hydrazine hydrate yielded the same 2-hydrazino derivative 4. Treatment of 4 with 2,4-pentanedione, 2-acetylcyclohexanone and ethyl acetoacetate afforded the corresponding pyrazolylpyrido[2,3- d]pyrimidine derivatives (5–7), while phthalic anhydride gave the phthalazinyl compound 8. Ethoxymethylenemalononitrile with the hydrazine 4 formed the fused 1,2,4-triazepine 9, while triazolopyrido[2,3- d]pyrimidines were obtained from the reaction of 4 with benzylidene malononitrile or benzaldehyde (forming 10), acetic acid/anhydride (giving 11), and ethyl chloroformate (giving 12).
Synthesis of biogenetically possible 3-substituted pyrano-[2,3-a]carbazoles
Authors: Prabakaran Kumaresan , Prasad Karnam Jayaramapillai Rajendra
Published: December 2009

3-Substituted pyrano[2,3- a]carbazol-2(11 H)-ones have been synthesised by the reaction of 1-hydroxy-carbazole-2-carbaldehyde with malononitrile, ethyl cyanoacetate, Meldrum's acid, (carbethoxymethylene)triphenylphosphorane, ethyl benzoylacetate and phenylacetonitrile.
Convenient synthesis of amaryllidaceae alkaloid, (+/-) latifine dimethyl ether
Authors: Kumar A. Sanjeev , Ghosh Samir , Bhima Kale , Mehta G.N.
Published: December 2009

A short route for the synthesis of (+/-) latifine dimethyl ether is reported. The key steps involved are Grignard reaction, conversion of alcohol to nitrile using trimethylsilyl cyanide, reduction of the nitrile intermediate followed by Pictet–Spengler cyclisation and reductive N-methylation in a single step to provide latifine dimethyl ether as a racemate.
Addition of diaryl disulfides to terminal alkynes catalysed by an MCM-41-supported bidentate phosphine palladium(0) complex
Authors: Li Jianying , Liu Jun , Cai Mingzhong
Published: December 2009

A variety of ( Z)-1,2-bis(arylthio)-substituted alkenes have been conveniently synthesised in high yields by the stereoselective addition of diaryl disulfides to terminal alkynes catalysed by an MCM-41-supported bidentate phosphine palladium(0) complex. This polymeric palladium catalyst can be recovered and reused many times without any loss of activity.
Molecular iodine-catalysed amidation reaction of secondary benzylic and allylic alcohols with carboxamides or sulfonamides
Authors: Lin Xufeng , Wang Jun , Xu Fangxi , Wang Yanguang
Published: December 2009

A highly efficient method for the C–N bond formation via 2 mol% of molecular iodine-catalysed amidation reaction of benzylic and allylic alcohols with carboxamides or sulfonamides in MeCN is described, giving the corresponding substituted amides and allylic amides in moderate to excellent yields. The significan features of the procedure include mild and metal-free reaction conditions, operational simplicity, inexpensive reagents, short reaction time, and good yields.
Synthesis of esters and amides of 1,4-dihydro-1,2,4,5-tetrazine-3,6-dicarboxylic acid
Authors: Zhang Shi-Jie , Ma Yi-Chun , Zhou Wei , Rao Guo-Wu , Chen Liang-Liang , Hu Wei-Xiao
Published: December 2009

Alkyl esters and alkyl amides of 1,4-dihydro-1,2,4,5-tetrazine-3,6-dicarboxylic acid were synthesised and characterised by IR, 1H NMR, EI-MS and elemental analysis. The structure of 1,4-dihydro-1,2,4,5-tetrazine-3,6-dicarboxylic was confirmed by X-ray diffraction analysis. Some selected compounds were evaluated against P-388 and A-549 cancer cell lines, but showed poor inhibitory activities.
Convenient synthesis and reactions of some 7,9-dimethylthieno-[2,3-b:4,5-b‘]dipyridines
Authors: El-Dean Adel M. Kamal , Micky Gehan Ahmed Ali , Ahmed Abo Bakr Abdel-Hadi , Ahmed Rasha Hassan
Published: December 2009

3-Amino-4,6-dimethylthieno[2,3- b]pyridine-2-carboxaldehyde was prepared and from it various functionalised thieno[2,3- b:4,5- b‘]dipyridines were synthesised, using the Friedländer and related reactions. Ethyl 2,7,9-trimethylthieno[2,3- b:4,5- b‘]dipyridine-3-carboxylate was transformed into a variety of thieno[2,3- b:4,5- b‘]dipyridine systems with heterocyclic rings attached at C-3 or fused at C2–C3.
Regioselective synthesis of thiadiazolo[3,2-a]benzimidazole-5,8-diones
Authors: Srinivas Vakiti , Rao Vedula Rajeswar
Published: December 2009

Regioselective synthesis of the novel 7-hydroxy-2-(alkylsulfanyl)-6-undecyl[1,3,4]thiadiazolo[3,2- a]benzimidazole-5,8-diones was achieved by the reaction of 2,5-dihydroxy-6-undecyl-1,4-bezoquinone (embelin) with 5-(alkyl/aralkyl/ phenacylsulfanyl)-1,3,4-thiadiazol-2-amines in refluxing acetic acid.
Direct reductive amination of aldehydes and ketones mediated by a thiourea derivative as an organocatalyst
Authors: Huang Yi-Bo , Cai Chun
Published: December 2009

The direct reductive arylamination of arylaldehydes and ketones has been achieved using a selective imine activation by a hydrogen bond of a thiourea derivative. This mild, acid- and metal-free process requires a catalytic amount of N,N'-bis[3,5-bis(trifluoromethyl)phenyl]thiourea, the Hantzsch 1,4-dihydropydine diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate as hydride source and activated 5Å-molecule sieve as dehydrant. The method is adaptable for the synthesis of various amines.
Metal template effect on O-alkylation of tetrathiacalix[4]arene with 2-bromoacetamide to afford tetrakis(carbamoylmethoxy)thiacalix [4]arenes with cone and 1,3-alternate conformation
Authors: Rahman Shofiur , Shimizu Tomoe , Xi Zeng , Yamato Takehiko
Published: December 2009

Direct O-alkylation of tetrathiacalix[4]arene with 2-bromoacetamide afforded two conformational isomers ( cone and 1,3- alternate) of tetrakis(carbamoylmethoxy)thiacalix[4]arene and 1,3-disubstituted bis(carbamoylmethoxy)thiacalix [4]arene, depending on the base used.
A new hetisine-type diterpenoid alkaloid from Aconitum coreanum
Authors: Zhan Zha-Jun , Ma Lie-Feng , Zhang Xiao-Yong , Shan Wei-Guang
Published: December 2009

A new hetisine-type alkaloid, named as guan-fu base A1 (1), and five known alkaloids including guan-fu base G (2), guan-fu base Y (3), guan-fu base Z (4), guan-fu base Q (5) and coldephnine (6) were isolated from the roots of Aconitum coreanum. The structure of 1 was established by spectral methods, especially 2D NMR techniques.
Synthesis and conformational studies of 9-substituted [3.3]metacyclophane-2,11-diones and conversion to the corresponding [3.3]metacyclophanes
Authors: Shimizu Tomoe , Ueno Ryuji , Ziewandy Masa'odi , Yamato Takehiko
Published: December 2009

Various anti-9-substituted [3.3]MCP-2,11-diones are exclusively obtained by the coupling reaction of the corresponding 1,3-bis(bromomethyl)benzenes and 2,6-bis[2-isocyano-2-(tolylsulfonyl)ethyl]-4- tert-butylbenzenes in dimethylformamide (DMF) with an excess of sodium hydride, from which the corresponding syn-[3.3]MCP are synthesised via anti- syn-isomerisation during the Wolff-Kishner reduction.
Solvent-Free Synthesis of New Heteryl β-ketosulfones
Authors: Guravaiah Nalajam , Rao Vedula Rajeswar
Published: December 2009

A novel efficient method for the coupling of sulfinic acid salts and α-halo ketones is described. A variety of heteryl β-ketosulfones have been formed in an excellent yields at room temperature under solvent-free conditions.
Aqueous Phase Supramoleculer Synthesis of 3,2- and 3,3-dihetero-aromatic oxindoles catalysed by β-cyclodextrin
Authors: Naskar Subhendu , Saha Pritam , Paira Rupankar , Paira Priyankar , Hazra Abhijit , Sahu Krishnendu B. , Banerjee Sukdeb , Mondal Nirup B.
Published: December 2009

A high yielding green protocol is described for the synthesis of 3,2 and 3,3-diheteroaromatic oxindole involving the condensation of isatin with indole or pyrrole in an aqueous medium under neutral conditions by supramoleculer catalysis by β-cyclodextrin. The β-cyclodextrin can be easily recovered and reused without any loss of activity.
A Facile Stereoselective Synthesis of (Z)-2-ethoxycarbonyl-substituted 1,3-enynes from (E)-α-stannyl-α,β-unsaturated esters and alkynyl bromides
Authors: Dai Ruchun , Xi Zhiwen , Cai Mingzhong
Published: December 2009

Palladium-catalysed hydrostannylation of alkynyl esters in benzene at room temperature gives regio- and stereoselectively ( E)-α-stannyl-α,β-unsaturated esters in good yields. ( E)-α-Stannyl-α,β-unsaturated ethyl esters are difunctional group reagents which undergo Stille coupling reactions with alkynyl bromides in the presence of Pd(PPh3)4 and Cul co-catalyst to afford stereoselectively ( Z)-2-ethoxycarbonyl-substituted 1,3-enynes in good yields.
Synthesis of 1-[aryl-(pyrimidin-2-ylamino)-methyl]-naphthalen-2-ols by p-toluenesulfonic acid catalysed reaction between 2-naphthol, aromatic aldehydes and 2-aminopyrimidine
Authors: Anary-Abbasinejad Mohammad , Akhavan Mahboobeh , Hassanabadi Alireza
Published: December 2009

Three-component reaction between 2-naphthol, an aromatic aldehyde and 2-aminopyrimidine catalysed by p-toluenesulfonic acid provided a simple and efficient one-pot route for the synthesis of 1-[aryl-(pyrimidin-2-ylamino)-methyl]-naphthalen-2-ol derivatives in excellent yields.
Phenanthroline Ligands with Divergent Pyridine Units
Authors: Vysotsky Myroslav O.
Published: December 2009

2-Mono- and 2,9-di-substituted 1,10-phenanthrolines with 4-pyridine units attached either via 1,4-phenylene- or 4-ethynyl-phenyl spacers, have been synthesised. The strategy is based on the introduction of 4-trimethylsilylphenyl group(s) at the phenanthroline core with the subsequent ipso-substitution of TMS groups by bromine or iodine and successive Suzuki or Sonogashira reactions with 4-pyridineboronic acid or 4-ethynylpyridine, respectively.
An Efficient, Catalyst- and Solvent-Free Synthesis of imidazo[1,2-a]pyridines and 2,4-disubstituted thiazoles on Grinding
Authors: Zhu Dongjian , Chen Jiuxi , Wu Dengze , Liu Miaochang , Ding Jinchang , Wu Huayue
Published: December 2009

An efficient synthesis of imidazo[1,2- a]pyridines and 2,4-disubstituted thiazoles in excellent yield under catalyst-and solvent-free conditions at room temperature on grinding has been developed. The important features of this method are that it is reasonably fast, very clean, high yielding, simple workup and environmentally benign.
Ytterbium (III) triflate catalysed [3 + 2] cycloaddition involving isothiocyanates and epichlorohydrin
Authors: Xie Yuanyuan , Chen Xiaodong , Su Weike
Published: December 2009

Highly regioselective cycloadditions occur in reactions of substituted isothiocyanates and epichlorohydrin to give N-(5-(chloromethyl)-1,3-oxathiolan-2-ylidene)anilines catalysed by Yb(OTf)3. The configuration is retained at the chiral centres of the epoxides.
Synthesis and Characterisation of Some Hexadentate Schiff-base Ligands Containing the Piperazine Moiety
Authors: Keypour Hassan , Rezaeivala Majid , Dehghani-Firouzabadi Ahmad Ali
Published: December 2009

Ten hexadentate (N4O2, N4S2 and N6) Schiff-base ligands have been prepared by condensation of various aldehydes and two different linear tetraamines containing the piperazine moiety. The products have been characterised by melting point, elemental analysis and various spectroscopic methods such as: FT-IR, 1H, 13C NMR, and EI mass spectrometry. The complex [Co{N, N'-bis[(pyridin-2-ylmethylene)ethyl]piperazine}][ClO4]2 has been prepared.
Synthesis and X-ray Crystallographic Study of K[Ni(NH2CH3CHCOO)3].3H2O
Authors: Khatib Awni , Aqra Fathi , Deamer David , Oliver Allen
Published: December 2009

A complex of formula K[ Ni( NH2 CH3 CHCOO)3].3 H2 O has been prepared from nickel(II) chloride in aqueous solution by adding L-alanine and potassium hydroxide. It has been crystallised from DMSO and its structure determined by X-ray crystal structure analysis. The nickel(II) atom adopts distorted octahedral coordination geometry with three bidentate alanine molecules. The complex is anionic and synthesised in the form of the potassium salt. The network crystal structure shows hydrogen bonding between all the chelate molecules, and each K[ Ni( NH2 CH3 CHCOO)3] fragment contains three water molecules as hydrated water. The geometry of the potassium ion is octahedral.
Regioselective Synthesis of rac-(1R,4R,6R,6aR)-6′-phenyl-7′,8′-dihydro-1″H,2′H,6′H-dispiro[cycloalkane-1,5′-pyrrolo[1,2-c][1,3]thiazole-4′,3″-indole]-2,2″-diones through 3 + 2 cycloaddition Reaction
Authors: Poornachandran Mahalingam , Jayagobi Mathesan , Raghunathan Raghavachary
Published: December 2009

Synthesis of a series of novel rac-(1 R,4 R,6 R,6a R)-6′-phenyl-7′,8′-dihydro-1″ H,2′ H,6′ H-dispiro[cycloalkane-1,5′-pyrrolo[1,2- c][1,3]thiazole-4′,3″-indole]-2,2″-diones by cycloaddition reaction is described. The nonstabilised azomethine ylide generated by the reaction of isatin and thiazolidine-2-carboxylic acid has been regioselectively trapped by various substituted benzylidene cycloalkanones.
Synthesis of 4-oxazolinephenylboronic acid and heterobiaryl oxazolines via a Suzuki Reaction
Authors: Ghosh Samir , Kumar A. Sanjeev , Mehta G.N. , Soundararajan R. , Sen Subhabrata
Published: December 2009

An efficient synthesis of 4-oxazolinephenylboronic acid from 4-bromobenzoic acid is reported. The title compound couples with heteroaryl halides in presence of Pd(PPh3)4 and Na2CO3 in aqueous toluene to give heterobiaryl oxazolines.
Synthesis and Biological Activities of Some Schiff's Bases from 4-amino-3-(3-hydroxybutyl)-1H-1, 2, 4-triazole-5-thione
Authors: Zhang Jing , Zhang Lixue , Lei Xinxiang , Zhou Changfeng , Fu Xiaodan , Zhang Haile
Published: December 2009

Sixteen novel Schiff's bases have been synthesised in high yields from 4-amino-3-(3-hydroxybutyl)-1 H-1, 2, 4-triazole-5-thione. All the newly synthesised compounds have been characterised by elemental analysis, IR, 1H NMR, 13C NMR and MS. Plant growth-regulating activity tests showed that most compounds have remarkable effects on the growth of wheat and radish at a mass concentration of 50μg mL−1.
Synthesis and Anticoccidial Activity of ethyl 6-substitutedbenzyloxy-7-alkoxy-4-hydroxyquinoline-3-carboxylates
Authors: Zou Yan , Yan Chun-Rong , Weng Ya-Biao , Li Juan , Wu Kai-Qun , Wang Yu-Liang , Wang Yu-Zhong
Published: December 2009

A series of novel ethyl 6-substitutedbenzyloxy-7-alkoxy-4-hydroxyquinoline-3-carboxylates have been designed and synthesised from 4-nitro-2-alkoxyphenol. Their structures have been characterised by 1H NMR, HRMS and IR spectra. Anticoccidial activities of these compounds were evaluated according to the ACI (the anticoccidial index) method. The results indicated that three of the tested compounds exhibited anticoccidial activities against Eimeria tenella in chicken feed with a dose of 27 mg/kg.
Synthesis and Antimicrobial Activity of Bisphosphonates
Authors: Reddy M. Veera Narayana , Reddy K.R. Kishore Kumar , Reddy C. Bhupendra , Kumar B. Siva , Reddy C. Suresh , Reddy C. Devendranath
Published: December 2009

Dimethyl [(substitutedphenyl)(6-oxo6λ5dibenzo[ d,f][1,3,2]dioxaphophepin-6-yl)methyl]phosphonates (5a-j) were synthesised through a three step process involving preparation of dimethyl hydroxy(substitutedphenyl)methyl-phosphonates (4a-j) and their reaction with 6-bromodibenzo[ d,f][1,3,2]dioxaphosphepine (2) in dry toluene in the presence of triethylamine at 50–60°C. Tetramethylguanidine (TMG) as a catalyst was found to increase the yields and purity of the products. These compounds were characterised by IR, 1H, 13C, 31P NMR and mass spectral data found to possess higher antimicrobial activity then the standards.
Synthesis, Crystal Structures and Spectra Properties of Two New Cu(II) Complexes Containing Thiocyanato Anions as Ancillary Ligand
Authors: Zhang Xiuqing , Bian Hedong , Gu Wen , Xu Jingyuan , Yan Shiping , Liang Hong
Published: December 2009

As the result of different ratio of reactants, two novel mixed–ligand complexes with different structures have been synthesised and characterised by IR and electronic spectra. In [Cu(L)(NCS)]2·0.5H2O, (L = N,N-dimethyl-N‘– (pyrid-2-ylmethyl)ethylenediamine), there are two crystallographically independent mononuclear units which are enantiomers. The thiocyanato anions act as terminal ligands. In [Cu2(L)2( μ2–NCS)2]2(ClO4)2, two thiocyanato anions bridge two Cu(II) ions in the end–to–end mode.
The Synthesis of Benzimidazole Derivatives in the Absence of Solvent and Catalyst
Authors: Yu Chuanming , Guo Peng , Jin Can , Su Weike
Published: December 2009

Differently substituted benzimidazoles have been synthesised from o-phenylenediamine and arylaldehydes or arylmethylene-malononitriles absorbed on silica gel. The reaction was carried out by intermittent grinding or by a microwave-assisted technique under solvent- and catalyst-free conditions giving good yields of the products.
Characterisation of novel macroacyclic hexadentate (N4O2 and N2O4) Schiff base ligands and their zinc(II), copper(II) and cobalt(II) complexes, with ligands derived from reduction
Authors: Keypour Hassan , Rudbari Hadi Amiri , Azadbakht Reza , Lotf Ebrahim Abouzari
Published: December 2009

The macrocyclic, hexadentate (N4O2 and N2O4) Schiff base ligands, 1,2-bis(2′-nitrophenoxy)benzene, 1,2-bis (2′-nitrophenoxy)-4- t-butylbenzene), 1,2-bis(2′-aminophenoxy)benzene and 1,2-bis(2′-aminophenoxy)-4- t-butyl-benzene have been synthesised, together with macroacyclic hexadentate ligands formed from their reduction. Zinc(II), copper(II) and cobalt(II) complexes of the Schiff base ligands have also been prepared and all compounds have been characterised by spectroscopy and elemental analysis.
Iodine catalysed synthesis of 5-(arylmethylidene)rhodanines by Grinding under Solvent-Free Conditions
Authors: Wang Hongshe , Zeng June
Published: December 2009

5-(Arylmethylidene)rhodanines have been synthesised in 88–95% yields by Knoevenagel condensation of various aromatic aldehydes with rhodanine in the presence of a catalytic amount of iodine at room temperature by grinding under solvent-free conditions.
Characterisation of 3,7-dibromophenothiazin-5-ium perbromide and its use for enhancing latent fingerprints
Authors: Plater M. John , Harrison William T. A.
Published: December 2009

Solutions were formulated by dissolving 3,7-dibromophenothiazin-5-ium perbromide in primary and secondary alcohols with pyridine as base. These solutions were used as dips for the enhancement of latent fingerprints. Treatment of 3,7-dibromophenothiazin-5-ium perbromide with cyclohexene or sodium sulfite gave 3,7-dibromophenothiazine.
Estrano[17,16-e]pyrimidine-amino acid and estrano[17,16-e]pyrimidine-peptide conjugates
Authors: Matsumoto Tomohiro , Shiine Kodai , Mataka Shuntaro , Thiemann Thies
Published: December 2009

Estrone has been converted to an aminopyrimidino [17,16-e]-annelated estrane derivative. A number of amino acids, dipeptides and tripeptides have been linked to the aminopyrimidino unit of the annelated steroid. The tripeptide motifs may be used for the complexation of metals, such as of technetium as a radiolabel for the potential detection of estrogen positive breast cancer cells.
Novel Preparation of gefitinib
Authors: Zheng Youguang , Li Mingdong , Zhang Shaoning , Ji Min
Published: December 2009

A new synthesis of the anticancer drug gefitinib is described starting from methyl 3-hydroxy-4-methoxybenzoate. The sequence involves alkylation of the starting material, followed by nitration, reduction, cyclisation, chlorination and amination reactions. This new method has six steps, uses a much cheaper starting material and has higher yields than other methods. It is suitable for industrial production.
One-Pot, Nickel triflate-catalysed homocoupling of aryl chlorides in the Presence of Metallic Magnesium
Authors: Lv Dan , Zhang Yan-Yan , Li Jing-Hua
Published: December 2009

The homocoupling reaction of aryl chlorides was successfully performed in one-pot without preparation of a Grignard reagent in advance. Various aryl chlorides underwent homocoupling reactions affording the corresponding symmetrical biaryls in moderate to good yields. The nickel triflate catalyst was recovered easily and reused smoothly with only a little loss of its activity.
A 2-hydroxy-l-naphthaldehyde-derived chemosensor for recognition of Cu2+
Authors: Xing Dai , Yun-Xu Yang , Xing-Feng Wang , Rui-Long Sheng
Published: December 2009

A new Schiff base formed by coupling 2-hydroxy-l-naphthaldehyde and Betti base can selectively recognise Cu2+ over other metal ions such as Zn2+, Cd2+, Sn2+, Pb2+, Hg2+, Ni2+, Mn2+, Cr3+, alkali metals and alkaline earth metals in acetonitrile/water. Cu2+ binds one mole of the base causing an obvious blue-shift (Δ = 43 nm) in its absorption spectrum and quenching its fluorescence emission. The stability constant is estimated to be 1.25 × 104 M−1.
Efficient chemoselective addition of Grignard reagents to carbonyl compounds in 2-methyltetrahydrofuran
Authors: Zhong Weihui , Wu Yaotiao , Zhang Xingxian
Published: December 2009

Compared with tetrahydrofuran (THF) as a solvent for the addition reactions between Grignard reagents and carbonyl compounds 2-methyltetrahydrofuran affords the corresponding adducts in higher yields with higher chemoselectivities. Moreover, 2-methyltetrahydrofuran can be readily recycled and reused, which lowers the cost of the process and makes the reaction greener.
Studies with 2-(acetonylthio)benzothiazole. New routes to isoxazoles, isoxazolo[3,4-b]pyridines, pyrazolo[1,5-a]pyrimidines, pyridines and quinolizines
Authors: Al-Omran Fatima , El-Khair Adel A.
Published: December 2009

Derivatives of isoxazole, isoxazolo[3,4- b]pyridine, pyrazolo-[1,5- a]pyrimidine and pyridin-2(1 H)-one incorporating a benzothiazole-2-thio residue have been synthesised. The structures of these newly synthesised compounds are characterised by elemental analysis, IR, 1H and 13C NMR, NOE and MS.
Synthesis and X-ray Structure of New Molecular Clips Based on diphenylglycoluril
Authors: Sheng-Li Hu , Yan-Dong Wu , Jing Li , Kun-Ru Wang , An-Xin Wu
Published: December 2009

A pair of new molecular clips based on diphenylglycoluril and 1, 2-dihydroindazol-3-one have been synthesised. Their structures and conformations were confirmed by single crystal X-ray diffraction.
A new eudesmane sesquiterpene from Senecio cannabifolius
Authors: Gao Xue , Deng Xiaohong
Published: December 2009

A new eudesmane sesquiterpene was isolated from the roots of Senecio cannabifolius. Its structure was established as 1-oxo-5α, 7αH-eudesma-3-en-15-al on the basis of spectroscopic data, including IR, EI-MS, HR-ESI-MS, 1D and 2D NMR spectroscopy.
Three new lipids from the seeds of Trogopterus xanthipes
Authors: Yang Nian-Yun , Tao Wei-Wei , Duan Jin-Ao
Published: December 2009

Chemical investigation of Feces Trogopterus ( Trogopterus xanthipes) has led to the isolation of three new lipids, including two new cerebrosides, 1- O-β-D-glucopyranosyloxy)-(2 S,3 S,4 R,6 E)-2-[(2′ R)-2′-hydroxyheptadecanoylamino]-8-heptadecene-3,4-diol (1) and 1- O-β-D- glucopyranosyloxy)-(2 S,3 S,4 R,6 E)-2-[(2′ R)-2′-hydroxy-heptadecanoylamino]-8-nonadecene-3,4-diol (2), and one new fatty acid ester, bis(2,3-dihydoxypropyl)-tetracosanedioate (3). Their structures were elucidated by chemical and spectral means. This is the first report on the occurrence of cerebroside and fatty diacid diester in Feces Trogopterus.
Synthesis of novel unsymmetrical molecular clips derived from glycoluril
Authors: Sheng-Li Hu , Yan-Dong Wu , Li-Ping Cao , An-Xin Wu
Published: December 2009

Four novel unsymmetrical molecular clips derived from glycoluril have been designed and synthesised and the structure and conformation of one was also confirmed by single crystal X-ray diffraction.
Facile Synthesis of Heterocycles Having Bacteriocidal Activity Incorporating Oleic Acid Residues
Authors: Salam Hayam A. Abd El , Shaker Nehal O. , El-Telbani Emad M. , Nawwar Galal A.M.
Published: December 2009

Synthesis of various heterocycles having fatty acid residues is described using ethyl-4-(hexadec-7-enyl)-3-oxobutanoate as starting material by reaction with different reagents. Preliminary antibacterial testing showed that the compounds ethyl-4-(hexadec-7-enyl)-3-oxobutanoate and 3-[octadec-9-ene-1-one]-chromen-2-one are the most promising.
Crystal structure of 3-chlorobenzo[b]thiophene-2-carbonyl chloride
Authors: Tarighi Sara , Abbasi Alireza , Zamanian Sara , Badiei Alireza , Ghoranneviss Mahmood
Published: December 2009

3-Chlorobenzo[b]thiophene-2-carbonyl chloride was synthesised from cinnamic acid and thionyl chloride. The single crystal X-ray structure determination confirmed the earlier proposed structure and the product was further characterised by 1H NMR, 13C NMR and mass spectrometry. The X-ray structure determination revealed two sets of symmetry related molecules along the b-axis that are loosely connected by relatively weak CH…π ( 3.626, 3.628 Å) interactions, giving rise to two infinite chains. The packing structure is dominated by Van der Waals forces between these chains. No significant π–π interactions are found in the crystal structure.
An efficient synthesis of (+/-) cherylline dimethyl ether
Authors: Kumar A. Sanjeev , Ghosh Samir , Bhima Kale , Mehta G.N.
Published: December 2009

A concise route for the synthesis of (+/-) cherylline dimethyl ether is reported. The key steps involved are Grignard reaction, conversion of alcohol to nitrile using (N-( p-toluene sulfonyl)imidazole and sodium cyanide), reduction of the nitrile intermediate followed by Pictet–Spengler cyclisation and reductive N-methylation in a single step to provide cherylline dimethyl ether as a racemate.
Synthesis, characterisation and luminescence properties of novel Eu(TTA)3-co-polymer and Tb(TPC)3-co-polymer
Authors: Wang Siqing , Cang Hui , Yang Wenzhong , Wang Jintang
Published: December 2009

This report describes the synthesis, characterisation and luminescence properties of Eu(TTA)3-co-polymer (where TTA is 2-thenoyltrifluoroacetonate) and Tb(TPC)3-co-polymer (where TPC is 2-thiophenecarboxylic acid).
Sustainability of accelerated rice production in Bangladesh: Technological issues and the environment
Authors: Chowdhury Mohammad AT
Published: December 2009

Key Words: Sustainabiity, ecosystems, yield, urbanization, soil degradation. DOI: 10.3329/bjar.v34i3.3979 Bangladesh J. Agril. Res. 34(3) : 523-529, September 2009