bluuebunny/crossref_metadata_2025 huggingface dataset:
Survival of Inpatients under 5 Years Old with Bronchiolitis by Laboratory-Confirmed Respiratory Syncytial Virus Infection
Authors: Mendoza-Cano Oliver , Trujillo Xóchitl , Huerta Miguel , Ríos-Silva Mónica , Guzmán-Esquivel José , Benites-Godínez Verónica , Bricio-Barrios Jaime Alberto , Ríos-Bracamontes Eder Fernando , Lugo-Radillo Agustín , Murillo-Zamora Efrén
Published: December 2022

Background: The respiratory syncytial virus infection (RSV) spread has been unusually high during 2022 and increasing trends have been documented We aimed to assess the survival experience of children hospitalized due bronchiolitis by laboratory-confirmed RSV. Methods: A nationwide and retrospective cohort was conducted in Mexico and data from 436 children aged 5 years and younger, with symptoms onset from August 2021 to November 2022, were analyzed. Survivor functions and 95% confidence intervals (CI) were computed by using the Kaplan-Meier method. Results: The survival rates were high, particularly within the first three weeks of admission. The 3-day survival was 99.8% (CI 95% 98.4-99.9%) and went to 98.9% (CI 95% 96.5-99.7%), 97.5% (CI 95% 91.9-99.3%), 86.7% (95% CI 48.2-97.2%), and 69.4% (95% CI 24.2-91.0%) on days 7, 14, 21 and 28 of hospital stay, respectively. We documented 5 fatal outcomes, and the mortality rate was 2.1 per 1,000 person-days. Conclusions: We analyzed a large set of pediatric patients with bronchiolitis by RSV and the presented results contribute to achieving a better understanding of the in-hospital evolution of this disease.
Model Wind Optimization with Satellite Wind Observations for Operational Sea Level Prediction
Authors: De Biasio Francesco , Zecchetto Stefano
Published: December 2022

Sea surface wind forecasts in the Adriatic Sea often suffer for unadequate modelling, especially for the wind speed. This has detrimental effects on the accuracy of sea level and storm surge predictions. We present a numerical method to reduce the bias between the sea surface wind observed by the scatterometers and that supplied by the European Centre for Medium-Range Weather Forecasts (ECMWF) global atmospheric model, for storm surge forecasting applications. The method, called “wind bias mitigation”, relies on scatterometer observations to determine a multiplicative factor ∆ws which modulates the standard model wind in order to decrease the bias between scatterometer and model. We compare four different mathematical approaches to this method, for a total of eight different formulations of the multiplicative factor ∆ws. Four datasets are used for the assessment of the eight different bias mitigation methods: a collection of 29 Storm Surge Events (SEVs) cases in the years 2004-2014, a collection of 48 SEVs in the years 2013-2016, a collection of 364 cases of random sea level conditions in the same period, and a collection of the seven SEVs in 2012-2016 that were worst predicted by the Centro Previsioni e Segnalazioni Maree, Comune di Venezia (Tide Forecast and Early Warning Centre of the Venice Municipality - CPSM). The statistical analysis shows that the bias mitigation procedures supplies a mean wind speed more accurate than the standard forecast, when compared with scatterometer observations, in more than 70% of the analyzed cases.
Asymptotic bounds for average-case complexity of Boolean functions
Authors: Chashkin Aleksandr Viktorovich
Published: December 2022

Some results obtained in recent years concerning the average-case complexity of computing Boolean functions by straight line programs with conditional stop are considered. These programs generalize the concept of a Boolean circuit and are a natural model of straight line computations, i.e., computations that do not involve conditional branching or indirect addressing, but allow an early termination under a certain condition. Such computations can be informally described as follows. Computations are executed by a processor with memory consisting of cells. The processor is capable of computing some number of elementary functions, which form the computational basis. At any moment of time, each memory cell is accessible to the processor for both reading and writing data. The processor is controlled by a program that is a sequence of elementary instructions of two types. Every instruction of the first type computes the value of a basis function whose arguments are contained in certain memory cells. The computed result is also placed in a memory cell. An instruction of the second type can terminate the execution of a program. Every such instruction has a single argument, which is contained in a memory cell. If the value of the argument is equal to a certain fixed number, say, unity, then the processor terminates the program execution. If the argument has a different value, then the next instruction of the program is executed. There are special memory cells whose values are declared to be the result of executing the program after its termination. A natural measure of the complexity of such a program is the running time averaged over all possible arguments.
Information and Mathematical Models of the Flow Part in the Problems of Optimal Design of a Turboblock
Authors: Sherfedinov Riza , Usatyi Oleksandr , Avdieieva Olena
Published: December 2022

The issues of improving the structural-topological formation of the information model of the flow path of a steam turbine with the aim of using it in the problems of optimal design of turbine blocks are considered. A new hierarchical level "Compartment" has been added, which made it possible to link in a single information space the parameters of the frequency converter and the rest of the equipment of the turbine unit and made it possible to set and solve the problems of optimal design of turbine blocks. An improved one-dimensional model of the processes in the frequency converter, which allows simulating the course of processes in the frequency converter of a turbine from compartment to compartment (sub-section modeling of processes in the frequency converter with given steam parameters between the compartments). The improved mathematical model of the processes in the frequency converter is coordinated with the improved information model of the frequency converter and is one of the components of the optimal design subsystem of the “Turboagregat” CAD system. The performed test comparative calculations of the FC of steam turbine cylinders were carried out using algorithms created on the basis of two mathematical models: the original and the improved one. Good agreement was confirmed. Insignificant differences in thermogasdynamic parameters in the cross-sections between the rims of the inverter, obtained according to the original and improved models, are noted. Small deviations in the results are mainly caused by the need to use in the improved model the formulation of the problem with the given steam parameters in front of each compartment and the value of the mass flow rate to the head of each compartment. The fulfillment of the boundary conditions was ensured by a corresponding change in the effective angle of the nozzle grate of the first stage of each compartment.
MAIN TRENDS AND DIRECTIONS IN THE OPTIMAL DESIGN OF WHEEL MACHINE TRANSMISSIONS (REVIEW ARTICLE)
Authors: Bondarenko Oleksiy , Ustynenko Oleksandr
Published: December 2022

Modern requirements for the design process of any technical object are very strict. Focus and independence, reduction of time for the process itself, maximum automation of the process, complexity - all these are integral characteristics of modern design. Therefore, approaches to the optimal design of technical systems are quite widespread. For technical objects, it is advisable to use the term optimal-rational design. In this paper, mechanical step transmissions are considered. It should be noted that mechanical step transmissions is the most common type and covers all classes of vehicles, from light vehicles, through trucks, to military vehicles and special-purpose equipment. This prevalence has led to a wide range of layout schemes and different aggregate-saturation. These aspects led engineers to formulate a number of specific requirements for mechanical step transmissions, which resulted in certain quality characteristics - criteria and use various concepts, techniques and design approaches. For the authors, it is mechanical step transmissions of wheeled vehicles that is of interest, as the big segment of transport equipment. Thus, the description of methods, approaches and directions to the optimal-rational design mechanical step transmissions wheeled vehicles is an urgent task that will reveal the "blank spots" of this issue, determine the advantages and disadvantages of existing areas and help to choose a vector of further scientific thought and determine the approaches and methods to optimal-rational design mechanical step transmissions wheeled vehicles. Several general directions of mechanical step transmissions wheeled vehicles design are highlighted: the choice of transmission parameters, taking into account the dynamics of torsional vibrations, rational distribution of torque between the drive wheels, power distribution in the transmission, selection of rational shift phases, etc. The main objects of research and common methods for solving design problems are described. A graphical representation of the presented material is provided, which allows you to quickly navigate the issue, and, if necessary, modify existing or synthesize new tasks.
Keywords: transmission, optimal design, research directions
COMPLEMENTARY ENERGY PRINCIPLE FOR CABLE NETWORKS IN TERMS OF FORCE VECTOR VARIABLE
Authors: Tkachuk Mykola M.
Published: December 2022

An alternative approach to the variation formulation of static equilibrium  problem for cable networks is proposed. The dual minimization principle is derived in terms of force variables. The full vector force in the cable member is chosen as the dual variable. Unlike the previously proposed treatments of the problem using the scalar axial force variable the elastic energy retains the most general form until the closing steps. It is only assumed to be a convex function of the member end-to-end vector. As a result the nonsmooth asymmetric response of the cable does not appear in the form of inequality in the very beginning. Instead it shows up in the final form of the complementary energy functional, which turn out to be non-differentiable for zero member forces. The kinematic relations between member elongations and nodal displacements convert into the force equilibrium conditions in terms of nodal reactions and member force vectors. The Dirichlet boundary conditions appear in the dual form as a linear term in the complementary energy functional. For the linear elastic cables this approach lead to a second-order cone optimization problem with two sets conical constraints. Such formulation provides flexibility and thus can be potentially extended to account for phenomena such as inter-fiber friction and adhesion.
Keywords: complementary energy, variational principles, cable networks
CONTACT INTERACTION OF SIMILAR SHAPE BODIES AT SMALL DISTURBANCE OF INITIAL GAP DISTRIBUTION
Authors: Grabovskiy Andrey , Tkachuk Mykola А. , Kokhanovska Olga , Tkachuk Mykola M. , Domina Natalia , Tkachuk Ganna , Saverska Mariia , Kutsenko Serhii , Klochkov Illia , Voloshina Iryna , Tretyak Vladeslav
Published: December 2022

In this work, on the development of previous research, a model of contact interaction of similar shape bodies is built. Contact in the system "punch - stamped material - matrix" is considered. A gap is set between the material to be stamped and the matrix, which varies in circular coordinate. The regularities of the change of contact pressure and contact areas with variation of the law of distribution of the initial gap are determined. The influence of the load level on these parameters is also determined. In particular, the analysis of the influence of the number of waves in the distribution of the initial gap in the circular direction on the nature of the distribution of contact areas and contact pressure. It is established that at low level of loads significant non-uniformity of the contact pressure distribution along the circular coordinate is realized. In the future, with increasing load levels, this unevenness decreases. The distribution of contact pressure tends to the case of contact with nominally coincident surfaces of the matrix and the material to be stamped, i.e. at zero gap. Thus, an analytical-numerical method for studying the contact interaction of closely shaped bodies with low perturbation of the initial gap distribution has been developed. Regularities of influence of constructive and technological parameters on contact interaction of these bodies on an example of elements of stamp equipment are also established.
Keywords: contact interaction; stress-strain state; elements of stamps; contact area; contact pressure
Software for computer simulation of multiphysics processes in electromagnets and actuators of vacuum switching devices taking into account contact interaction of structural elements. Part 1: general overview; features of in-house codes
Authors: Panteliat Mykhailo , Kuzmin Artem
Published: December 2022

For computer modeling of multiphysics processes in complex modern technical objects, for example, in actuators and electromagnets of vacuum switching devices, it is necessary to use modern application software aimed at solving the entire spectrum of the specified problems or one or another "subset" of them. Complexes of applied programs must implement modern mathematical models and corresponding effective numerical algorithms, as well as have convenient interfaces both for the preparation and input of initial information (preprocessor), and for the output and analysis of the obtained results (postprocessor). The presence of the most "user-friendly" preprocessor and postprocessor is extremely important, considering the significant complexity of the processes being modeled, as well as the structures considered by the researcher and/or design engineer. It is of interest to carry out a comparative analysis of specific software products, with the aim of choosing a "tool" for the implementation of a complex of computational studies (computer modeling of multiphysics processes in the structural elements of medium and high voltage vacuum switching devices, taking into account contact phenomena), specified above. The article considers the criteria by which a reasonable choice of software can be made, which will be directly used for mathematical modeling of technical objects and processes under consideration.
SYSTEMATIC APPROACH TO VALUE EVALUATION OF THE PATENT PORTFOLIO
Authors: Svishchova Nataliia
Published: December 2022

The article points out the advantages of conducting agreements on purchase and sale of intellectual property not individual patents, but a portfolio of patents. A systematic analysis of the range of valuation of intellectual property and the patent portfolio was conducted. A mathematical explanation of the "maximum-minimum" values is given, as well as the separation of the actual market price is substantiated. A graphical analysis of the stages of life cycles is given. Based on the proposed mathematical model, the value of the basic invention according to the patent UA85101 and the general portfolio of patents of JSC "Ukrainian Power Machines" (Kharkiv, Ukraine) as of 01.02.2022, which is 1755810 UAH. These calculations assume the best economic effect of using the rights to this portfolio of patents both in-house and obtaining income from the sale of a non-exclusive license. The practical applicability of the study allows JSC "Ukrainian Energy Machines" to assess the possibility of improving the efficiency of intellectual property management, which provides maximum benefit from the commercialization of innovations.
THE PLACE OF TECHNOLOGICAL RE-ENGINEERING IN THE METHODOLOGY OF THE SYSTEMIC DESCRIPTION OF INNOVATIONS
Authors: Popov Oleksandr , Mekhovych Serhii
Published: December 2022

The article describes technological reengineering and defines its place in the methodology of describing innovations - technical, technological, organizational, logistical, etc. In the domestic practice of innovative transformations, such tools as rehabilitation, reorganization and restructuring are known. The effectiveness of their application largely depends on the level of integration, perfection and application methodology. Technological reengineering is a derivative tool of innovative transformations, therefore its fundamental aspects are considered together with the concepts of "technological innovations", "management" and "engineering". These tools are characterized. Based on the analysis of the existing interpretations of the concepts of "innovation", "technology", "reengineering" and "reengineering of business processes", the author's definition of the concept of "technological reengineering" is given, which by its nature embodies the elements of all these definitions. The concept of "technological reengineering" specifies the elements of the organizational and economic mechanism of the enterprise, within which fundamental transformations are carried out. The structural and logical essence of the concept of "technological reengineering" is considered as a systemic transformation on a fundamentally new technological basis of the production and technical base and the corresponding organizational and production relations. In contrast to the approaches presented in the scientific literature, the latter represents formalized procedures for radical, complex and systematic transformation of the production base in order to ensure the competitiveness of enterprises and regions and contains production and technical measures that are primarily related to the fundamental renewal of production assets, improvement product quality and cost reduction, improvement of the range of manufactured products. This allows us to detail the essence of this concept and to separate intellectual and technical tools for its implementation, such as remediation, restructuring, reengineering of business processes. It is justified that this definition more comprehensively covers the areas of reengineering and involves the redesign of business processes together with all components of the enterprise's activities. The given definition also allows for the formation of theoretical and methodological provisions regarding the definition of "technological reengineering".
PECULIARITIES OF MANAGING THE IMPLEMENTATION OF REGIONAL INNOVATIVE TRANSFORMATIONS
Authors: Popov Oleksandr , Mekhovych Serhii
Published: December 2022

The article examines the problems of innovative transformations of domestic industries in view of the state and attractiveness of the innovative environment, in which the leading place belongs to scientific research. It was noted that among all spheres of activity, it was science that suffered the most significant losses. In Ukraine, there is a tendency to reduce the number of researchers, which leads to a gradual degradation of the scientific potential. The state of technology transfer according to the first, second and third strategic priorities is of concern because this is a real sector of the economy on which the country's competitiveness depends and which needs reengineering transformations in the first place. The concept of technological reengineering in conditions of clustering of the national economy relies on enterprises of the high-tech sector. The science-intensive sector in Ukraine generates GDP at the level of the most backward countries in the world due to too few types of economic activity (FDI) that meet the criteria of high technology. At the same time, its share of added value in output is the largest among other technological sectors. This shows that science produces high-tech and competitive products. The cluster with its system of connections is aimed at creating systems of machines that meet the needs of the market. For modern clusters of knowledge-intensive production, such a task can be accomplished if attention is focused not only on resource provision, but also on various (several) determinants of market demand, which are formed on the types of market activity. It is justified that the cluster with its communication system is aimed at creating machine systems that meet the needs of the market. The combination of all components of the effect has a positive effect on the readiness of firms and organizations to cooperate with cluster structures, and this is a factor of regional development.
Continuous Integration for a development process of the information technology of remote monitoring and control
Authors: Mnushka Oksana , Leonov Serhii , Savchenko Volodymyr
Published: December 2022

The current state of using CI/CD in commercial and open-source projects is analyzed. CI/CD pipelines are shown to be essential to the modern software development process, where they are used to configure workflows. Centralized and distributed approaches to building a software source code version control system are analyzed. For the web-oriented SCADA project, the choice and use of the version control system are justified. We provide concrete examples of using CI/CD that will allow ordinary developers, not DevOps specialists, to take the first steps to configure workflows for their projects and provide basic steps for configuring task execution using the example of the build and test phase of the source code of a real project that uses several programming languages. Figs: 4. Refs. 20 titles.

Keywords: CI, CD, VCS, git, workflow, actions, building, testing, Agile.
Modeling of the system of intravascular cooling of donor organs
Authors: Zabilo Yaroslav , Shlykov Vladyslav , Kozyar Vasyl
Published: December 2022

The practice of transplants includes the transportation of donor organs within countries, between countries and continents using various complex and expensive systems capable of ensuring the viability of these organs for a certain time. As a result, there is a need to develop a reliable and easy-to-use cooling system, the cost of which would be acceptable for healthcare facilities. A separate problem is the development of the design of the intravascular cooling system to preserve the viability of the organ intended for transplantation, taking into account its characteristics. Illustration: 6. Table: 1. Refs.: 10 titles.

Keywords: transplantation, transportation of donor organs, organ viability, cooling system, Peltier element, temperature stabilization.
DEVELOPMENT AND SOFTWARE IMPLEMENTATION OF AN ALGORITHMIC MODEL FOR BROADCASTING DOCUMENTS ON VARIOUS DEVICES
Authors: Tatarinova Oksana , Marusenko Oleksii , Isaiev Vladyslav
Published: December 2022

The work designed, developed and implemented a web application intended for the transmission of electronic documents on various devices among the audience located at a distance from each other. The work is devoted to the development of approaches, algorithms and services for broadcasting documents of various formats on various devices without the use of a projector. Classical methods of data compression and encryption and parallelism were used to build the algorithms. The software is implemented in the JavaScript language using the Node.js and Vue.js frameworks. The MongoDB database is also used to store user data. To display the results of the work, a service was developed for broadcasting documents of various formats through a mobile device to other devices. A convenient software architecture has been developed, which allows you to easily maintain and improve the service in the future. A convenient and clear graphical interface for interaction with the user has been implemented. As you know, the direct use of classical methods and algorithms of data compression and encryption enables reliable use and storage of user data. Among many algorithms, the RSA method was used. The RSA method is a public-key cryptographic algorithm based on the computational complexity of the problem of multiplying large integers. Also, for greater efficiency in the service, parallelism methods and microservice architecture were developed. Their purpose is to distribute the load of the service on different subservices for greater efficiency of the program.
ПОДХОДЫ К ОЦЕНКЕ ЭФФЕКТИВНОСТИ ИСПОЛЬЗОВАНИЯ МЕДИЦИНСКОГО ОБОРУДОВАНИЯ НА ПРИМЕРЕ АППАРАТОВ ДЛЯ МАММОГРАФИИ
Authors:   ФГБУ ", Обухова Ольга ,   ЦНИИОИЗ",   Минздрава России
Published: December 2022

Издание содержит аналитические материалы оценки использования маммографических аппаратов в субъектах Российской Федерации по данным официальной статистической отчетности за 2016 – 2021 годы. Методика оценки использования маммографических аппаратов, которая является частью издания, позволит на уровне субъектов Российской Федерации формировать эффективные организационные решения по достижению целевых показателей национального проекта "Борьба с онкологическими заболеваниями". Книга предназначена для руководителей и работников финансово-экономических служб органов управления здравоохранением, медицинских организаций, специалистов медицинских информационно-аналитических центров субъектов Российской Федерации
Royalty as a Way to Protect Creator: Current Conditions in Indonesia
Authors: Maddusila Sitti Fatimah
Published: December 2022

One of the legal rights that must be protected is intellectual property rights. This study analyzes intellectual property legal protection aspects based on a royalty system. This research is the normative legal research to produce legal arguments, usually called legal prescriptions. This study uses primary legal materials, which include: the 1945 Constitution of the Republic of Indonesia, the Patent Law, the Copyright Law, the Government Regulation on Song and/or Music Royalties, also the Plant Variety Royalties Act. Secondary legal materials include the results of studies and research on aspects of royalties in intellectual property rights. Non-legal material includes various non-legal studies of the royalty system in intellectual property. The approach in this research is a conceptual approach and a statutory approach. The results of the study confirm that the implication of the implementation of the royalty system in intellectual property rights requires the state to realize three fundamental legal values ​​related to royalty policies, such as guarantees of legal certainty over the rules regarding royalties, guarantees of benefit from the distribution of royalties, as well as guarantees of fair distribution of royalties based on the principle of proportionality. In addition, legal protection with a royalty system in intellectual property rights needs to be carried out externally and internally.

Highlights: 

Royalty system needs legal certainty, benefits, and fair distribution.

Fair distribution based on proportionality is important.

External and internal legal protection is necessary.

Keywords: Royalty, Intellectual Property Rights, Legal Value
Legal Uncertainty Regarding the Application of The Principle of Territoriality in the Immigration Area
Authors: Widodo Rizal Fitroh Dwi , Rifa’i M. Hafiz , Wiratama Jhonata
Published: December 2022

The area of ​​immigration is an important aspect of immigration law enforcement and practice. This is because the immigration area preventively represents the sovereignty of a country. Even so, in the Immigration Law in Indonesia there are no special regulations regarding the immigration area. So there is the problem of a legal vacuum related to special regulations regarding the immigration area. This research is a normative legal research with a statutory and conceptual approach. The results of the study confirm that the principle of territoriality in the immigration area requires legal certainty. This is because in the practice of immigration, the principle of territoriality is an important principle, one of which is trying to prevent it from protecting the sovereignty of the state. In addition, the government needs to make a special legal product that regulates immigration areas in the form of Government Regulations and Presidential Regulations which can then be followed up technically with the regulations below. Technical follow-up to Government Regulations and Presidential Regulations can be in the form of a Regulation of the Minister of Home Affairs and specifically technical instructions regarding immigration areas can be formed for officers and law enforcement officers in the immigration sector who are specifically tasked with immigration areas.
The Need for National and State Ethics Laws in Indonesia
Authors: Boerhan Soebagio , Sidharta Dudik Djaja
Published: December 2022

The study of constitutional law does not only study positive law, but also includes national and state ethics. Indonesia actually has TAP MPR No. 4 on the Ethics of National Life. Although in its application the ethics of nation and state are still not effective in practice in society. This study aims to examine TAP MPR No. VI concerning the Ethics of National Life and its implementation in various aspects and future arrangements. This research is a normative legal research. Legal materials in this study include primary, secondary, and non-legal materials. The approach in this study uses a conceptual approach and a statutory approach. The results of the study confirmed that the implications of TAP MPR No. VI concerning the Ethics of National Life in constitutional law in Indonesia actually requires special arrangements in the Act so that it becomes the Law on the Ethics of National and State Life. The future implementation and regulation of the TAP MPR on National and State Ethics in Indonesian constitutional law can be carried out by establishing a Law on National and State Ethics which contains basic principles and is instrumentally and specifically determined by each agency, profession or group in society, combining the socialization of the four pillars of the MPR with the socialization of awareness of national and state ethics, and making awareness of national and state ethics as part of the national education system.
The Reformulation of Abortion Regulations: Study of the Ratio Legis and Ius Constituendum
Authors: Putri Dinda Fefty Miranda , Azizah Ainul , Tannuwijaya Fanny
Published: December 2022

Abortion can actually be carried out with various special provisions based on Law no. 36 of 2009 concerning Health (Health Law) and Government Regulation no. 61 of 2014 concerning Reproductive Health (PP Kespro). This study aims to find out the legal review regarding abortion in relation to the principle of protection for rape victims, as well as to study and formulate an appropriate and appropriate timeframe for carrying out an abortion based on the principle of protection for rape victims. This research is normative legal research by prioritizing conceptual and statutory approaches. The results of the study confirm that the legal ratio for setting the fetal age limit related to abortion for rape victims does not actually explain the reasons or the urgency why the 6 weeks and 40 (forty) days are calculated from the first day of the last menstrual period formulated by the formulators of laws and regulations and only refers to The principle of protecting victims is currently the main orientation of Indonesian criminal law. In the future, the regulation on the principle of protection for victims related to the fetal age limit related to abortion for victims of rape, namely: it is necessary to emphasize the principle of protection for victims in the Health Law. The recommendation of this research is the need for a revision of the Health Law and PP on Produce as based on WHO provisions and with relevant medical considerations.
Meaningful Participation in Local Regulation Making in Indonesia: A Study of Legislative Law
Authors: Rizqi Alda Rifada
Published: December 2022

The meaningful participation aspect is one of the conceptions born after the Constitutional Court's decision regarding job creation law. It is carefully considered, as well as the right to obtain answers and justifiable reasons for the aspirations that have been conveyed. This study examines the application of meaningful participation in forming Regional Regulations. This research is normative legal research with a concept and statutory approach. The research results confirm that meaningful participation must also be applied in preparing regional regulations as part of the legislation. In this case, meaningful participation in the drafting of Regional Regulations must also be proportional and meaningful in taking into account the dimensions and aspects of local wisdom in the regions. In a further application, the idea of meaningful participation needs to be strengthened in preparing regional regulations and regional legal products by emphasizing the meaningful participation aspect in the Permendagri regional legal products. That is so that the idea of meaningful participation can be adhered to by the regions in drafting regional legal products, particularly in drafting regional regulations.
Impacto de la leucemia linfoblástica aguda en el microbioma y lesiones bucales: revisión de alcance
Authors: García Rico Olga Leticia , Sánchez Medina Juan Gerardo , Sánchez Becerra Elizabeth , Cepeda Bravo Juan Antonio , Tejeda Nava Francisco Javier , Rocha Viggiano Ana Karenina , Salgado Bustamante Mariana , Aranda Romo Saray
Published: December 2022

Objetivo: Describir el conocimiento existente sobre las alteraciones del MBO y la presencia LO en pacientes con LLA. Materiales y Métodos: Se realizó una búsqueda electrónica en las bases de datos PubMed, Scielo y Google académico y se incluyeron artículos descriptivos, analíticos, observacionales sobre MBO, LO y LLA. Se evaluaron 642, se eliminaron artículos duplicados, reporte de caso y aquellos donde solo reportaran los cambios durante o después del tratamiento quimioterapéutico. Resultados: Se evaluaron 10 artículos, publicados entre 1997 y 2021, 4 artículos coincidieron que el MBO de pacientes con LLA se encuentra en disbiosis mostrando un aumento significativo de firmicutes, bacillus, y bacterias oportunistas como Moraxella spp, Klebsiella spp , Pseudomona spp ,Enterobacter spp , Acinetobacter spp y E . coli, las LO más frecuentes reportadas en 5 artículos fueron sangrado gingival espontáneo, gingivitis y úlceras. Conclusiones: La cavidad oral de los pacientes con LLA se encuentra en disbiosis y se identifican LO asociadas. Es necesario establecer estrategias preventivas con un enfoque nicho-ecológico para restablecer el MBO, con la finalidad de disminuir el riesgo de infecciones oportunistas y otras LO durante el tratamiento de quimioterapia.
Periimplantitis: conceptos actuales sobre su etiología, características clínicas e imagenológicas. Una revisión
Authors: Martínez Gómez Juan Carlos , Hernández-Andara Adalsa , Quevedo-Piña Maira , Ortega-Pertuz Ana Isabel , Lyn Chong Mee
Published: December 2022

La periimplantitis (PI) es la reacción inflamatoria de la mucosa periimplantaria, acompañada de la pérdida progresiva del hueso de soporte alrededor del implante, lo que puede comprometer su estabilidad, función y estética. Es diagnosticada mediante la medición radiográfica del nivel óseo alveolar, con o sin síntomas clínicos de inflamación, y una profundidad al sondaje mayor a 4 mm. El objetivo de este trabajo fue revisar la evidencia científica sobre la prevalencia, etiología, factores predisponentes, comportamiento clínico y las características imagenológicas de la PI. Se realizó una búsqueda electrónica en Google Scholar, PubMed y SciELO, considerando el periodo comprendido entre 2010-2022, y se seleccionó un total de 40 artículos. Se concluye que el agente etiológico principal de la PI es la biopelícula; sin embargo, su aparición y severidad puede estar asociada con la presencia de factores predisponentes, como diabetes mellitus, tabaquismo, enfermedad periodontal preexistente y ausencia de mucosa queratinizada, entre otros. Clínicamente, la PI está relacionada con el sangrado al sondaje, recesión gingival y supuración. La evaluación imagenológica del defecto periimplantar es realizada rutinariamente con radiografías periapicales; el uso reciente de tomografía computarizada de haz cónico ha permitido la valoración tridimensional del defecto, aunque se han realizado consideraciones sobre la dosis de radiación para el paciente y los artefactos de imagen que pueden limitar su uso de forma extensiva.
Imbalance of vaginal microbiota and immunity: two main accomplices of cervical cancer
Authors: Li Xiaoge , Wu Jin , Wu Yutong , Duan Zhaoning , Luo Ming , Li Ling , Li Sijing , Jia Ying
Published: December 2022

Objective: To explore the relationship between female vaginal microbiota and immune factors and its correlation with cervical cancer.
Methods: Here, we assessed the distribution patterns of microbiota in four groups of women from cervical cancer, HPV positive CIN, HPV positive non-CIN and HPV negative women. Microbial 16S rDNA sequencing and Protein chip were used to detect the composition and changes of vaginal microbiota and immune factors in the four groups, respectively.
Results: Alpha diversity analysis showed that the diversity of the vaginal microbiota increased with disease. OTUs analysis showed that the level of vaginal flora genus was dominated by Lactobacillus, Prevotella and Gardnerella in these four groups. LEfSe analysis showed that compared with the HPV negative group, the differentially dominant bacteria included Prevotella, Ralstonia and Gardnerella in the cervical cancer group, Gardnerella, Prevotella and Sneathia in the HPV positive CIN group and Gardnerella and Prevotella in the HPV positive non-CIN group, respectively. Lactobacillus and Atopobium were predominant in the HPV negative group (LDA>4log10). Compared with other groups, the abundance of Lactobacillusdecreased, the abundance of Prevotella and Gardnerellaincreased, and the contents of immune inflammatory factors IP-10 and VEGF-A increased in the cervical cancer group (P < 0.05).
Conclusions: The occurrence of cervical cancer is related to the change of vaginal microbiota and body immune status. Cervical cancer patients have increased vaginal microbiota diversity and increased immune inflammatory factors, which creates a favorable inflammatory environment for the occurrence of cancer. Therefore, it is of great significance to adjust and restore the balance of vaginal microbiota and maintain normal immune function in the prevention and treatment of cervical cancer.
This trial was registered at the Chinese Clinical Trial Registry (www.chictr.org.cn) (trial registration number ChiCTR2200060479,First registration time: 03 / 06 / 2022).
Hydroxychloroquine impairs mTORC1-dependent cholesterol biosynthesis and sensitizes retinal pigment epithelial cells to UV-induced cell death.
Authors: Wicks Ian , Kim Man Lyang , De Souza David , Narayana Vinod , Nguyen Nghi , Sleebs Brad
Published: December 2022

Hydroxychloroquine (HCQ) is a widely used and effective immunomodulatory drug. HCQ can cause dose-related retinal damage, thought to be due to inhibitory effects on lysosomes and autophagy. Using a human retinal pigment epithelial cell line (ARPE-19 cells), we confirm HCQ's inhibitory effect on autophagy and report that it inhibits mTORC1-mediated cholesterol biosynthesis. Cellular cholesterol content regulates lysosomal membrane permeability and thereby influences sensitivity to cell death. Cellular cholesterol insufficiency renders ARPE-19 cells more susceptible to a critical environmental threat, namely UV-induced cell death. We also show that HCQ induces apoptosis-independent disruption of phospholipid asymmetry, whereby caspase-independent phosphatidylserine (PS) exposure is mediated by cytosolic cathepsin B. HCQ-induced, caspase-independent PS exposure was inhibitable by the neutral pH-selective cathepsin B inhibitor Z-Arg-Lys-AOMK and was amplified by cholesterol lowering (simvastatin) and depleting (methyl-beta cyclodextrin) agents. We therefore conclude that HCQ also induces the release of lysosomal cathepsin B into the cytosol in response to lysosomal membrane permeability caused by cellular cholesterol insufficiency. We suggest that restricting UV exposure and avoiding cholesterol-lowering agents in combination with long term administration of HCQ might offer preventative strategies to protect against HCQ-induced retinal degeneration. We also provide evidence that neutral pH-selective cathepsin B inhibitors could represent a novel approach to treatment. Our findings may have broader implications for the prevention of retinal cell death and preservation of vision.
Association between dietary factors and breast cancer risk: A matched case-control study in Ho Chi Minh City, Vietnam
Authors: Nguyen Hien , Phung An , Nguyen Le , Nguyen Quynh , Tran Thach , Nguyen Tuan , Ho-Pham Lan
Published: December 2022

Background
The role of diet in breast cancer prevention is controversial. This study aimed to investigate the association between different dietary factors and breast cancer risk in Vietnamese women.
Methods
370 newly histologically confirmed breast cancer cases and 370 controls matched by 5-year age from September 2019 to March 2020 in Ho Chi Minh City were recorded dietary intake using a validated food frequency questionnaire. Odds ratios (OR) and 95% confidence intervals (95% CI) were evaluated using conditional logistic regression and adjusted with potential confounders.
Results
Compared to the lowest quartile of intake, we found that the highest intake of vegetables, fruit, soybean products, coffee, and egg significantly decreased breast cancer risk, including dark green vegetables (OR 0.46, 95% CI 0.27-0.78, ptrend=0.022), legumes (OR 0.2, 95% CI 0.08-0.47, ptrend <0.001), starchy vegetables (OR 0.37, 95% CI 0.21-0.66, ptrend=0.003), other vegetables (OR 0.47, 95% CI 0.28-0.78, ptrend=0.106), fruits (OR 0.43, 95% CI 0.25-0.74, ptrend <0.001), soybean product (OR 0.45, 95% CI 0.23-0.85, ptrend=0.311), coffee (OR 0.47, 95% CI 0.23-0.95, ptrend=0.004), and egg (OR 0.4, 95% CI 0.23-0.71, ptrend=0.002).
Conclusion
Greater consumption of vegetables, fruit, soybean products, coffee, and egg is associated with a lower risk of breast cancer. This study provides evidence of breast cancer prevention by increasing the intake of these dietary groups.
The Relationship between Stratospheric Gravity Wave Potential Energy and Tropospheric Parameters over South America inferred from COSMIC-2 and METOP Radio Occultation Measurements
Authors: Ayorinde Toyese Tunde , Wrasse Cristiano Max , Takahashi Hisao , Barros Diego da Silva , Figueiredo Cosme Alexandre Oliveira Barros , Lomotey Solomon Otoo , Essien Patrick , Bilibio Anderson Vestena
Published: December 2022

Using COSMIC-2 and METOP radio occultation measurements during the years 2020 and 2021, the study presents the first direct and independent relationship between the potential energy (Ep) in the stratosphere, precipitable water vapour (PWV), tropopause heights, and cold-point heights over South America. The South American continent comprises the tropical region, the Andes Mountain range, and the mid-latitude climates. The seasonal mean of the potential energy (Ep), the PWV, and the tropopause parameters height (TPH and CPH) were obtained to investigate the relationship between the SGW Ep and the tropospheric parameters (PWV, TPH, and CPH). Around the Andes Mountains to the east, there is significantly less water vapour (PWV < 10 mm) and relatively high gravity wave Ep (Ep > 8 kJ kg− 1). A good correlation of variability was found between the PWV and the lower stratospheric gravity wave (SGW) Ep in summer over the tropical region (± 20◦). Our result affirmed the possibility that convective activity was a major driver of the tropical gravity waves over South America. In the subtropical (30◦-40◦) region, especially in the winter, the tropospheric parameters make little or no contribution to gravity wave activity in the region. The tropopause and the cold-point temperature showed an anti-correlation (r > − 0.6) with SGW over the South American tropics. The SGW activities in the tropical region showed an impact on the structure of the tropopause parameters, which could be a result of the convective activity in this region.
VEGFA may be a potential marker of myopic choroidal thickness and vascular density changes
Authors: Wan Ting , Shi Wenqing , Liang Rongbin , Li Tao , Li Bing , Zhou Xiaodong
Published: December 2022

Introduction:To evaluate the changes of choroidal thickness（CT） and blood flow related to myopia, and its effects of vascular endothelial growth factor (VEGFA) on choroidal vessels in myopia.Methods:137 subjects were included and divided into emmetropia (EM), non-high myopia (Non-HM) and high myopia (HM) groups. we measured choroidal thickness (CT), choriocapillaris vessel density (VD), and VEGFA content in tears in humans and detected the role of VEGFA in the choroid in form-deprivation myopia (FDM) in guinea pigs. Twenty-four guinea pigs were divided into control and Form deprivation myopia (FDM) groups, and the expression changes of choroidal vessels and VEGFA were observed and compared using immunohistochemistry and Western blotting. Twenty-one guinea pigs were divided into control, FDM+Vehicle and FDM+Conbercept groups. The changes of diopter, axis length and choroidal vessels after intravitreal injection of Conbercept were observed.Results:There were significant differences in CT and VD among the three groups (p<0.05). The expression of VEGFA in tears of myopic group decreased significantly, presenting EM< Non-HM <HM group. Compared with the control group, the area fraction of choroidal vessels in the FDM group decreased. we observed a reduction in choroidal vasculature in FDM guinea pigs along with significant downregulation of choroidal VEGFA expression. After intravitreal injection of Conbercept into FDM guinea pigs, the FDM + conbercept group had a greater degree of myopia, longer axial length and less vascular density in the choroid than the control group.Conclusions:we found thinner CT, less choriocapillaris VD, and lower VEGFA content in tears in the myopic group than in the emmetropia group in humans. After intravitreal injection of Conbercept, FDM + conbercept group had a greater degree of myopia, longer axial length and less vascular density in the choroid than the control group. VEGFA may participate in the regulation of choroidal blood vessels and blood flow in myopia. VEGFA may be a potential target for controlling myopia.
Novel application of succus entericus reinfusion after enterostomy：a case report
Authors: Hou Yabo , Wang Xinxin , Ma Bingqiang , Zhang Lihua , Yang Xiaojun
Published: December 2022

Intestinal fluid reinfusion combined with enteral nutrition can significantly improve the nutritional status of patients with severe enterostomy and accelerate their recovery. There are many disadvantages in traditional intestinal fluid infusion. This manuscripts reports a case of nutritional support after enterostomy with a modified intestinal fluid reinfusion device.
Diagnosis of Covid 19 disease using CT scan images and pre-trained models
Authors: Amouzegar Faezeh , Mirvaziri Hamid , Ghazizadeh-Ahsaee Mostafa , Shariatzadeh Mahdi
Published: December 2022

Diagnosis of Covid-19 disease is a necessity for its prevention and control. The use of deep learning methods has been considered a fast and accurate method. In this paper, by combining three well-known pre-trained networks in parallel, an attempt was made to distinguish coronavirus-infected samples from healthy samples. Negative log-likelihood loss function has been used for model training. CT scan images in the SARS-CoV-2 dataset were used for diagnosis. The SARS-CoV-2 dataset contains 2482 images of lung CT scans, of which 1252 images belong to Covid-19 infected samples. The proposed model was able to be about 97% accurate.