bluuebunny/crossref_metadata_2025 huggingface dataset:
The Epidemiology of Diabetic Kidney Disease
Authors: Hoogeveen Ellen K.
Published: August 2022

Globally, the incidence and prevalence of diabetes mellitus has risen dramatically, owing mainly to the increase in type 2 diabetes mellitus (T2DM). In 2021, 537 million people worldwide (11% of the global population) had diabetes, and this number is expected to increase to 783 million (12%) by 2045. The growing burden of T2DM is secondary to the pandemic of obesity, which in turn has been attributed to increased intake of processed food, reduced physical activity, and increased sedentary behaviour. This so-called western lifestyle is related with the global increase in urbanization and technological development. One of the most frequent and severe long-term complications of diabetes is diabetic kidney disease (DKD), defined as chronic kidney disease in a person with diabetes. Approximately 20–50% of patients with T2DM will ultimately develop DKD. Worldwide, DKD is the leading cause of chronic kidney disease and end-stage kidney disease, accounting for 50% of cases. In addition, DKD results in high cardiovascular morbidity and mortality, and decreases patients’ health-related quality of life. In this review we provide an update of the diagnosis, epidemiology, and causes of DKD.
On the Optimal Allocation of Urban and Rural Land Resources in Rapidly Urbanizing Areas of the Yangtze River Delta, China: A Case Study of the Nanjing Jiangbei New Area
Authors: Huang Wenjuan , Liu Chonggang
Published: August 2022

In the process of rapid urbanization, the coordination of the population–land relationship, the optimal allocation of land resources, and the improvement in land-use efficiency are the keys to ensuring the sustainable development of the region. This study takes the Nanjing Jiangbei New Area (NJNA), a national development zone in China, as a case study to construct an analytical framework for the regional population–land–industry (PLI) coupling coordination relationship. A spatial organization model of population–land (PL) flow is used to calculate the coupling coordination degree of PLI factors. The allocation of land resources is adjusted and optimized through the characteristics of the actual population served in the area to determine the new urban population that can be effectively accommodated by the new district. The comprehensive evaluation of the coordination degree of PLI coupling shows that the area connected with Jiangpu and Dacang Street has high development potential in terms of population concentration and construction land layout and can be used as a key area for future development. Based on the analysis of the spatial layout of the PL flow, further suggestions are made to optimize planning for the future population concentration area in NJNA. This study can also provide a reference for the optimal management of land resources in similar areas at home and abroad.
The Effect of IFT80 Deficiency in Osteocytes on Orthodontic Loading-Induced and Physiologic Bone Remodeling: In Vivo Study
Authors: Jeon Hyeran Helen , Kang Jessica , Li Jiahui (Madelaine) , Kim Douglas , Yuan Gongsheng , Almer Nicolette , Liu Min , Yang Shuying
Published: August 2022

Osteocytes are the main mechanosensory cells during orthodontic and physiologic bone remodeling. However, the question of how osteocytes transmit mechanical stimuli to biological responses remains largely unanswered. Intraflagellar transport (IFT) proteins are important for the formation and function of cilia, which are proposed to be mechanical sensors in osteocytes. In particular, IFT80 is highly expressed in mouse skulls and essential for ciliogenesis. This study aims to investigate the short- and long-term effects of IFT80 deletion in osteocytes on orthodontic bone remodeling and physiological bone remodeling in response to masticatory force. We examined 10-week-old experimental DMP1 CRE+.IFT80f/f and littermate control DMP1 CRE−.IFT80f/f mice. After 5 and 12 days of orthodontic force loading, the orthodontic tooth movement distance and bone parameters were evaluated using microCT. Osteoclast formation was assessed using TRAP-stained paraffin sections. The expression of sclerostin and RANKL was examined using immunofluorescence stain. We found that the deletion of IFT80 in osteocytes did not significantly impact either orthodontic or physiologic bone remodeling, as demonstrated by similar OTM distances, osteoclast numbers, bone volume fractions (bone volume/total volume), bone mineral densities, and the expressions of sclerostin and RANKL. Our findings suggest that there are other possible mechanosensory systems in osteocytes and anatomic limitations to cilia deflection in osteocytes in vivo.
Immune-Checkpoint-Inhibitor-Related Lung Toxicity: A Multicentre Real-Life Retrospective Portrait from Six Italian Centres
Authors: Cameli Paolo , Faverio Paola , Ferrari Katia , Bonti Viola , Marsili Stefania , Mazzei Maria Antonietta , Mazzoni Francesca , Bartolucci Maurizio , Scotti Vieri , Bertolini Federica , Barbieri Fausto , Baldessari Cinzia , Veronese Chiara , Boffi Roberto , Brighenti Matteo , Cortinovis Diego , Dominici Massimo , Pesci Alberto , Bargagli Elena , Luppi Fabrizio
Published: August 2022

Background: Immune checkpoint inhibitors (ICIs) have revolutionized the therapeutic horizons of various cancers. However, immune-related adverse events have been reported, including interstitial lung diseases. Our aim was to describe the clinical and radiological features and survival of a multicentre cohort of patients who developed ICI-related lung toxicity. Methods: Six Italian centres were involved in the study. Patients who were treated with anti-PD-1/PD-L1 and CTLA-4 mAbs and developed ICI-related lung toxicity were recruited retrospectively to study clinical, radiological, immunological and survival data. Results: A total of 41 patients (25 males, 66.8 ± 9.9 years) were enrolled. Lung toxicity occurred after 204.3 ± 208.3 days of therapy, with ground glass opacities being the most common HRCT pattern (23 cases). Male sex, lung cancer and acute respiratory failure were associated with a shorter latency of toxicity (p = 0.0030, p = 0.0245 and p = 0.0390, respectively). Patients who required high-flow oxygen therapy showed significantly worse survival (p = 0.0028). Conclusions: Our cohort showed heterogeneous clinical and radiological aspects of ICI-related lung toxicity, with a latency not limited to the first year of treatment. Severity was mainly mild to moderate, although life-threatening events did occur. Our data indicate that strict long-term follow-up is needed to enable early diagnosis and appropriate management.
Renoprotective and Oxidative Stress-Modulating Effects of Taxifolin against Cadmium-Induced Nephrotoxicity in Mice
Authors: Algefare Abdulmohsen I.
Published: August 2022

Cadmium (Cd) is an inessential trace metal that accumulates in the kidney and may lead to renal toxicity by mediating oxidative stress (OS), inflammatory reactions, and apoptosis. The main objective of this experiment was to inspect the protecting potential of taxifolin (TA) on Cd-induced renal toxicity. Adult male mice were allocated into equal five groups as follows: control, TA-treated (50 mg/kg, oral), CdCl2-treated (4 mg/kg body weight (BW), p.o.), pretreated with TA (25 mg/kg) 1 h before CdCl2 injection (4 mg/kg BW, p.o.), and pretreated with TA (50 mg/kg) 1 h before CdCl2 injection (4 mg/kg BW, p.o.) for 14 days. Cd-intoxicated mice revealed higher serum urea and creatinine levels and notable histopathological alterations in the renal tissues. Malondialdehyde (MDA), nitric oxide (NO), nuclear factor-kappa B (NF-κB) p65, tumor necrosis factor-α (TNF-α), and IL-1β were increased. In contrast, glutathione levels, catalase and superoxide dismutase activities, and IL-10 levels were decreased under Cd-administered effects. Conversely, the TA pre-treatment highly protected tissues from Cd-toxicity, improved renal function, decreased MDA and NO levels, attenuated inflammation, and improved redox status in the renal tissues of Cd-intoxicated mice. The TA pre-treatment of Cd-intoxicated mice showed down-regulation of both Bax and caspase-3 protein and up-regulation of Bcl-2 protein expression in the kidney. Furthermore, TA pre-treatment induced higher upregulation of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1) expression in kidney cells of Cd-intoxicated mice. Therefore, TA can protect renal tissues against Cd-induced nephrotoxicity via improving redox status, modulating inflammation, diminishing cell apoptosis, and activating the Nrf2/HO-1 signaling pathway.
Midterm Results of Iliac Branch Devices in a Newly Established Aortic Center
Authors: Borzsák Sarolta , Süvegh András , Szentiványi András , Fontanini Daniele Mariastefano , Vecsey-Nagy Milán , Banga Péter , Sótonyi Péter , Szeberin Zoltán , Csobay-Novák Csaba
Published: August 2022

The first-line treatment of common iliac artery aneurysms is endovascular repair. International guidelines recommend the preservation of the internal iliac artery, which is best achieved by the implantation of an iliac bifurcation device (IBD). Our aim was to evaluate the initial midterm results of IBDs in the leading vascular center of Hungary. In this single-center retrospective study, relevant clinical data and the results of the imaging examinations were collected and analyzed in all patients who underwent IBD implantation between December 2010 and July 2021. Thirty-five patients (31 males, mean age: 67.9 ± 8.5 years) underwent endovascular treatment with 37 IBD implantations. Technical success was achieved in 88.2% of the patients, with no perioperative mortality or open surgical conversion. One patient was lost during follow-up. Internal iliac artery occlusion was detected in three (8.8%) patients, and reintervention was performed in five (14.7%) patients. Primary patency of the internal iliac branch was 97.1% at 1 month, 93% at 2 months, and 89.0% at 5 years. The average follow-up time was 20.1 ± 26.2 months, during which two (5.9%) deaths occurred. Our initial experience with iliac branch devices was associated with a low complication rate and a favorable outcome, which confirms the midterm success of this intervention.
Cryopreservation of Pig Semen Using a Quercetin-Supplemented Freezing Extender
Authors: Bang Seonggyu , Tanga Bereket Molla , Fang Xun , Seong Gyeonghwan , Saadeldin Islam M. , Qamar Ahmad Yar , Lee Sanghoon , Kim Keun-Jung , Park Yun-Jae , Nabeel Abdelbagi Hamad Talha , Yu Il-jeoung , Cooray Akila , Lee Kyu Pil , Cho Jongki
Published: August 2022

Reactive oxygen species (ROS) produced during freeze–thaw procedures cause oxidative damage to the sperm, reducing fertility. We aimed to improve the post-thaw quality of pig sperm by quercetin (QRN) supplementation to reduce the cryodamage associated with the freeze–thaw procedure. Four equal aliquots of pooled boar semen were diluted with a freezing extender supplemented with different concentrations of QRN (0, 25, 50, and 100 µM) and then were subjected to cryopreservation in liquid nitrogen. Semen analysis was performed following 7 days of cryopreservation. Results demonstrated that the semen samples supplemented with 50 µM QRN significantly improved the post-thaw sperm quality than those subjected to other supplementations (p < 0.05). Semen samples supplemented with 50 µM QRN showed significantly improved plasma membrane functional integrity (47.5 ± 1.4 vs. 43.1 ± 4.1, 45.3 ± 1.7, and 44.1 ± 1.4) and acrosome integrity (73.6 ± 3.4 vs. 66.3 ± 2.4, 66.7 ± 3.6, and 68.3 ± 32.9) as compared to the control, 25 µM, and 100 µM QRN groups, respectively. The mitochondrial activity of the 50 µM QRN group was greater than control and 25 µM QRN groups (43.0 ± 1.0 vs. 39.1 ± 0.9 and 41.9 ± 1.0) but showed no difference with the 100 µM QRN group. Moreover, the 50 µM QRN group showed a higher sperm number displaced to 1 cm and 3 cm points in the artificial mucus than other groups. Therefore, supplementing the freezing extender with QRN can serve as an effective tool to reduce the magnitude of oxidative damage associated with sperm freezing.
ABO Blood Group in Relation to COVID-19 Susceptibility and Clinical Outcomes: A Retrospective Observational Study in the United Arab Emirates
Authors: Hafez Wael , Ahmed Shougyat , Abbas Nihad , Ahmed Kamran , Kamran Samera , Arya Arun , Rao Srinivasa Raghu , Abdelshakor Mahmoud , Ali Sara , Sebastian Honeymol , Tariq Mishal , Lal Kumar , Abdelrahman Ahmed
Published: August 2022

(1) Background: The association between ABO blood groups and COVID-19 outcomes was investigated in several studies. The results were controversial. This study aimed to explore the association between ABO blood groups and COVID-19 outcomes. (2) Methods: This retrospective study included 303 COVID-19 patients treated at the NMC Royal Hospital in the United Arab Emirates between 8 April 2020 and 30 June 2020. (3) Results: The mean age of patients included in the study was 39.3 ± 10.7 years, and 72.9% of patients were males. The prevalence of blood groups O, A, B, and AB was 40.3%, 27.7%, 25.1%, and 6.9%, respectively. The correlation between ABO blood groups and COVID-19 outcomes was insignificant except in the AB group, with significantly higher odds of disease severity. Increased age, higher body mass index (BMI), and being of male gender increased the risk for pneumonia among all blood groups. Both increased age and higher BMI increased the risk of mortality, and increased age increased the risk of disease severity. Troponin and platelet counts were significantly different in the A group compared to the non-A groups. Time to viral clearance was not different among blood groups. However, adjustment for Rh groups resulted in a significantly shorter time in the B group. (4) Conclusions: There was no significant association between ABO blood groups and COVID-19 outcomes, with the exception of group AB.
Rare Causes of Acute Coronary Syndrome: Carbon Monoxide Poisoning
Authors: Haliga Raluca Ecaterina , Morărașu Bianca Codrina , Șorodoc Victorița , Lionte Cătălina , Sîrbu Oana , Stoica Alexandra , Ceasovschih Alexandr , Constantin Mihai , Șorodoc Laurentiu
Published: August 2022

Acute coronary syndrome (ACS) is a spectrum of clinical and paraclinical disorders arising from an imbalance of oxygen demand and supply to the myocardium. The most common cause is atherosclerosis; however, other rare causes such as carbon monoxide (CO) poisoning should be considered. Through tissue hypoxia and direct cell injury, CO poisoning can lead to a broad spectrum of cardiac disorders, especially ACS. Materials and Methods. We have conducted a retrospective study in the Toxicology Department of Saint Spiridon Emergency University Hospital, including all patients admitted through the emergency department with CO poisoning. We divided the cohort into event group (myocardial injury) and non-event group (patients without myocardial injury) and performed a subset analysis of the former. Results. A total of 65 patients were included, 22 in the event and 43 in the non-event group. The severity of poisoning did not correlate with myocardial injury; however, 50% of the event group had severe poisoning with carboxyhaemoglobin ≥ 20%. Cardiac enzyme markers (troponin and creatin-kinase MB) had a statistically significant increase in the event group compared to the non-event group (p < 0.05). Most of the patients in the STEMI (50%) and NSTEMI (66.7%) groups had severe CO intoxication. The STEMI group had a mean age of 27.7 years old and no comorbidities. Conclusions. Myocardial injury can develop in CO poisoning irrespective of the severity of poisoning, and it can be transient, reversible, or permanent. Our study introduces new information on adverse cardiac events in patients with CO poisoning, focusing on the ACS. We found that the severity of CO poisoning plays an important role in developing myocardial injury, as 50% of patients in the event group were severely intoxicated. While in-hospital mortality in our study was low, further prospective studies should investigate the long-term mortality in these patients.
Long-Duration Space Travel Support Must Consider Wider Influences to Conserve Microbiota Composition and Function
Authors: Al Kait F. , Chmiel John A. , Stuivenberg Gerrit A. , Reid Gregor , Burton Jeremy P.
Published: August 2022

The microbiota is important for immune modulation, nutrient acquisition, vitamin production, and other aspects for long-term human health. Isolated model organisms can lose microbial diversity over time and humans are likely the same. Decreasing microbial diversity and the subsequent loss of function may accelerate disease progression on Earth, and to an even greater degree in space. For this reason, maintaining a healthy microbiome during spaceflight has recently garnered consideration. Diet, lifestyle, and consumption of beneficial microbes can shape the microbiota, but the replenishment we attain from environmental exposure to microbes is important too. Probiotics, prebiotics, fermented foods, fecal microbiota transplantation (FMT), and other methods of microbiota modulation currently available may be of benefit for shorter trips, but may not be viable options to overcome the unique challenges faced in long-term space travel. Novel fermented food products with particular impact on gut health, immune modulation, and other space-targeted health outcomes are worthy of exploration. Further consideration of potential microbial replenishment to humans, including from environmental sources to maintain a healthy microbiome, may also be required.
Suppression of Pepper mild mottle virus (PMMoV) by Modified Whey Proteins
Authors: Elsharkawy Mohsen Mohamed , Al-Askar Abdulaziz A. , Abdelkhalek Ahmed , Behiry Said I. , Kamran Muhammad , Ali Mostafa
Published: August 2022

Modified whey proteins with quercetin (WPI-QU) and onion extract (WPI-OE), as a control approach, could be applicable because it is available, safe and cheap. The modified whey protein isolate (WPI) with quercetin dihydrate and onion extract powder rich with quercetin were evaluated for induction of systemic resistance against Pepper mild mottle virus (PMMoV) in pepper plants. Data of mass spectrometry illustrated that one or more of Qu isomers covalently attached to WPI. Unmodified whey protein (UWPI), WPI-QU and WPI-OE significantly decreased PMMoV concentration and severity at two weeks after inoculation. Plant height, number of leaves, and shoot fresh and dry weights were substantially increased in WPI-QU- and WPI-OE-treated pepper plants compared to the control. Total antioxidant status (TAS) and vitamin C contents were highly increased in WPI-OE-treated plants compared with other treatments. The expression levels of defense related genes (PR4, PR9, TIN1 and PIN2) were enormously elevated in WPI-OE and WPI-QU treatments using qRT-PCR. In conclusion, the results give novel insights to possible applications of the WPI–quercetin bioconjugates in designing a wide range of functional products. Moreover, this study is the first to establish the effective control of PMMoV by modified whey proteins.
Nailfold Videocapillaroscopy for the Evaluation of Peripheral Microangiopathy in Rheumatoid Arthritis
Authors: Anyfanti Panagiota , Angeloudi Elena , Dara Athanasia , Arvanitaki Alexandra , Bekiari Eleni , Kitas George D. , Dimitroulas Theodoros
Published: August 2022

Rheumatoid arthritis (RA) is a chronic and refractory autoimmune joint disease that affects multiple organs. Several methods have been applied for the study of microvascular endothelial dysfunction, which is considered an important component of vascular disease in RA. Implementation of nailfold videocapillaroscopy (NVC) represents a viable choice, as the skin is an easily accessible window for the non-invasive, real-time assessment of subtle microcirculation abnormalities. Although NVC is routinely used in the rheumatology field, especially for the diagnostic workout of Raynaud’s phenomenon, accumulating evidence suggests a role in the evaluation of systemic vasculopathy associated with autoimmune rheumatic disorders. The current paper aims to provide an overview of NVC as a valuable clinical aid for the assessment of peripheral microcirculation in RA. Previous studies characterizing the capillaroscopic pattern in RA are summarized, along with associations with disease-related characteristics. Most available reports have mainly focused on the descriptions of non-specific morphological alterations that may reflect endothelial injury over the course of the disease. Still, the exact pattern of structural and functional capillaroscopic alterations and their clinical significance in RA remains a subject of ongoing research.
Enabling Clonal Analyses of Yeast in Outer Space by Encapsulation and Desiccation in Hollow Microparticles
Authors: Ng Simon , Williamson Cayden , van Zee Mark , Di Carlo Dino , Santa Maria Sergio R.
Published: August 2022

Studying microbes at the single-cell level in space can accelerate human space exploration both via the development of novel biotechnologies and via the understanding of cellular responses to space stressors and countermeasures. High-throughput technologies for screening natural and engineered cell populations can reveal cellular heterogeneity and identify high-performance cells. Here, we present a method to desiccate and preserve microbes in nanoliter-scale compartments, termed PicoShells, which are microparticles with a hollow inner cavity. In PicoShells, single cells are confined in an inner aqueous core by a porous hydrogel shell, allowing the diffusion of nutrients, wastes, and assay reagents for uninhibited cell growth and flexible assay protocols. Desiccated PicoShells offer analysis capabilities for single-cell derived colonies with a simple, low resource workflow, requiring only the addition of water to rehydrate hundreds of thousands of PicoShells and the single microbes encapsulated inside. Our desiccation method results in the recovery of desiccated microparticle morphology and porosity after a multi-week storage period and rehydration, with particle diameter and porosity metrics changing by less than 18% and 7%, respectively, compared to fresh microparticles. We also recorded the high viability of Saccharomyces cerevisiae yeast desiccated and rehydrated inside PicoShells, with only a 14% decrease in viability compared to non-desiccated yeast over 8.5 weeks, although we observed an 85% decrease in initial growth potential over the same duration. We show a proof-of-concept for a growth rate-based analysis of single-cell derived colonies in rehydrated PicoShells, where we identified 11% of the population that grows at an accelerated rate. Desiccated PicoShells thus provide a robust method for cell preservation before and during launch, promising a simple single-cell analysis method for studying heterogeneity in microbial populations in space.
Influence of Carbon Source on Microstructural and Mechanical Properties of High-Performance Reaction-Bonded Silicon Carbide
Authors: Zhou Yabin , Sha Wenhao , Liu Yingying , Lyu Yinong , Huang Yihua
Published: August 2022

Reaction-bonded silicon carbide (RBSC) has become an important structural ceramic with the benefit of being capable of preparing complex-shaped products. In order to fabricate high-performance RBSC, particle gradation of raw SiC combined with slip casting was used to prepare the porous preform before liquid silicon infiltration (LSI). The microstructural and mechanical properties of RBSC were compared by adding different amounts of carbon black (CB) content from 4 wt% to 10 wt%. Two pore structures with submicron and nano pores formed in the preform. As the amounts of carbon black increased, the mechanical properties improved and then suddenly weakened due to residual silicon initiating a nonuniform microstructure. The elastic modulus of the preform with 8 wt%CB after LSI was 389 ± 4 GPa and the flexural strength was 340 ± 17 MPa, which improved by about 150% compared to other rapid prototyping methods and has attractive application prospects.
Echinoderms Metabolites: Structure, Functions and Biomedical Perspectives II
Authors: Kalinin Vladimir I. , Silchenko Alexandra S.
Published: August 2022

Echinoderms belong to the phylum Echinodermata (from the Ancient Greek words “echinos” (hedgehog) and “derma” (skin)) [...]
Relationships between Alcohol Use, Musculoskeletal Pain, and Work-Related Burnout
Authors: Chen Yong-Hsin , Yeh Chih-Jung , Pan Lung-Fa , Jong Gwo-Ping
Published: August 2022

Background and Objectives: Burnout affects approximately half of all nurses, physicians, and other clinicians. Alcohol use may impair performance in work-related tasks, leading to decreased productivity and morale. The present study’s aim was to determine whether a causal relationship existed between alcohol use, work-related burnout (WB), and musculoskeletal pain. Materials and Methods: A total of 1633 members from a hospital affiliated with a medical university in Taichung, Taiwan, completed questionnaires in 2021, where 1615 questionnaires were declared valid. Questionnaires were used to obtain information on basic demographic variables, and the Nordic Musculoskeletal Questionnaire and Copenhagen Burnout Inventory were used. Statistical analyses were performed using SAS Enterprise Guide 6.1 software, and significance was set at p < 0.05. Results: Work experience, being married, parenthood, leisure activities with family and friends, and regular weekly exercise were negatively associated with WB. In addition, overtime work, irregular and regular shift work, the physician and nurse medical profession, chronic disease (heart disease, diabetes, etc.), neck and both shoulders pain (NBSP), both ankles pain (BAP), and alcohol use frequency (AUF) were positively associated with WB. NBSP could explain the residual effect of AUF on WB. AUF was determined to mediate the relationship between NBSP and WB. In addition, NBSP was found to mediate the relationship between AUF and WB. Conclusions: The individuals who used alcohol to cope with NBSP or those with NBSP who often consumed alcohol had worsened WB due to a vicious circle of musculoskeletal pain and alcohol use. Therefore, medical staff should not consider alcohol use as an option to reduce burnout.
Plants, Plants, and More Plants: Plant-Derived Nutrients and Their Protective Roles in Cognitive Function, Alzheimer’s Disease, and Other Dementias
Authors: Ding Helen , Reiss Allison B. , Pinkhasov Aaron , Kasselman Lora J.
Published: August 2022

Background and Objectives: Alzheimer’s disease (AD) is the most common form of dementia, with the risk of developing it attributed to non-modifiable and modifiable factors. Currently, there is no cure for AD. A plant-based diet may protect against cognitive decline, due to the effects of plant-based nutrients such as vitamins, antioxidants, and fiber. The aim of the review is to summarize current literature on plant-based nutrients and their impact on cognition. Materials and Methods: A search was conducted on PubMed for clinical and murine studies, using combinations of the following words: “Alzheimer’s disease”, “dementia”, “cognition”, “plant-based diet”, “mild cognitive impairment”, “vitamin B”, “vitamin C”, “vitamin E, “beta carotene”, “antioxidants”, “fiber”, “vitamin K”, “Mediterranean diet”, “vitamin D”, and “mushrooms”. Results and Conclusions: A diet rich in vitamin B and antioxidants can benefit the cognitive functions of individuals as shown in randomized clinical trials. Vitamin K is associated with improved cognition, although large randomized controlled trials need to be done. Fiber has been shown to prevent cognitive decline in animal studies. Vitamin D may contribute to cognitive health via anti-inflammatory processes. Several medical organizations have recommended a plant-based diet for optimizing cognitive health and potentially helping to prevent dementia.
Validation of Recycled Nanofiltration and Anion-Exchange Membranes for the Treatment of Urban Wastewater for Crop Irrigation
Authors: Pompa-Pernía Anamary , Molina Serena , Lejarazu-Larrañaga Amaia , Landaburu-Aguirre Junkal , García-Calvo Eloy
Published: August 2022

One of the alternative sources to tackle the problem of water shortage is the use of reclaimed water from wastewater treatment plants for irrigation purposes. However, when the wastewater has a high conductivity value, it becomes unusable for crop irrigation and needs a more specific treatment. In this work, recycled nanofiltration (rNF) membranes and anion-exchange membranes (rAEMs) obtained from end-of-life RO membranes were validated to evaluate their application capability in saline wastewater treatment. The use of recycled membranes may represent an advantage due to their lower cost and reduced environmental impact associated with their production, which integrates membrane-based technology into a circular economy model. Both recycled membranes were tested in crossflow filtration and electrodialysis (ED) systems. The results of the rNF membrane showed a high selective rejection of divalent ions (SO42− (>96%) and Ca2+ and Mg2+ (>93%)). In the case of the ED process, the comparison between rAEMs and commercial membranes showed an appropriate demineralization rate without compromising the power consumption. Finally, the quality of both system effluents was suitable for irrigation, which was compared to the WHO guideline and validated by the 7-week lettuce crop study.
Structure of the Human BK Ion Channel in Lipid Environment
Authors: Tonggu Lige , Wang Liguo
Published: August 2022

Voltage-gated and ligand-modulated ion channels play critical roles in excitable cells. To understand the interplay among voltage sensing, ligand binding, and channel opening, the structures of ion channels in various functional states and in lipid membrane environments need to be determined. Here, the random spherically constrained (RSC) single-particle cryo-EM method was employed to study human large conductance voltage- and calcium-activated potassium (hBK or hSlo1) channels reconstituted into liposomes. The hBK structure was determined at 3.5 Å resolution in the absence of Ca2+. Instead of the common fourfold symmetry observed in ligand-modulated ion channels, a twofold symmetry was observed in hBK in liposomes. Compared with the structure of isolated hSlo1 Ca2+ sensing gating rings, two opposing subunits in hBK unfurled, resulting in a wider opening towards the transmembrane region of hBK. In the pore gate domain, two opposing subunits also moved downwards relative to the two other subunits.
Design and Development of High-Strength and Ductile Ternary and Multicomponent Eutectoid Cu-Based Shape Memory Alloys: Problems and Perspectives
Authors: Pushin Vladimir G. , Kuranova Nataliya N. , Svirid Alexey E. , Uksusnikov Alexey N. , Ustyugov Yurii M.
Published: August 2022

An overview is presented on the structural and phase transformations and physical and mechanical properties of those multicomponent copper-based shape memory alloys which demonstrate attractive commercial potential due to their low cost, good shape memory characteristics, ease of fabrication, and excellent heat and electrical conductivity. However, their applications are very limited due to brittleness, reduced thermal stability, and mechanical strength—properties which are closely related to the microstructural features of these alloys. The efforts of the authors of this article were aimed at obtaining a favorable microstructure of alloys using new alternative methods of thermal and thermomechanical treatments. For the first time, the cyclic martensitic transformations during repeated quenching, methods of uniaxial megaplastic compression, or torsion under high pressure were successfully applied for radical size refinement of the grain structure of polycrystalline Cu-Al-Ni-based alloys with shape memory. The design of the ultra- and fine-grained structure by different methods determined (i) an unusual combination of strength and plasticity of these initially brittle alloys, both under controlled heat or hot compression or stretching, and during subsequent tensile tests at room temperature, and, as a consequence, (ii) highly reversible shape memory effects.
Effect of Solution Treatment Temperature on Microstructure and Properties of Fe-0.72Mn-3.7Al-0.53C Low-Density Cast Steel
Authors: Song Nan , Zhao Weimin , Dong Lishan , Zhou Xinshan
Published: August 2022

In the present research, the microstructure and mechanical properties of low-density Fe-0.72Mn-3.7Al-0.53C steel were investigated after solution treatment at 900 °C, 1000 °C, 1110 °C and 1200 °C for 1 h. The density of steel is about 7.0 g·cm−3 due to the addition of a higher content of aluminum elements. The microstructure was characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM), and the mechanical behavior was analyzed by room temperature tensile testing. The results show that the microstructure of the steel is ferrite and martensite after solution treatment, and that martensite can be divided into dislocation martensite and twinned martensite according to different substructures. Part of the martensite grows in a mirror-symmetrical manner in order to adjust the strain energy that increases with the system undercooling to form twinned martensite. After solution treatment at different temperatures, the tensile strength and elongation of the steel increased and then decreased with the increase of the solution treatment temperature, and the tensile strength could reach 928.92 MPa, while maintaining excellent toughness and elongation at 5.89%.
Study of New Mini-Channel Trans-Critical CO2 Heat Pump Gas Cooler
Authors: Jiang Jiawei , Liang Shiqiang , Ji Can , Wang Longyan , Guo Chaohong
Published: August 2022

A gas cooler is one of the important parts of a carbon dioxide (CO2) heat pump water heater, and it must meet the needs of not only pressurization but also heat transfer. It is important to study gas coolers. In this paper, a heat exchanger with a spiral channel is studied. ANSYS CFX software was used to analyze the flow and heat transfer characteristics of the heat exchanger (single-plate model). The influences of the cooling pressure of CO2, the mass flux of CO2, the mass flux of water and the channel radius of CO2 are discussed. In this paper, the results show that the cooling pressure of CO2, the mass flux of CO2 and the channel radius of CO2 all have a large influence on the local heat transfer coefficient: with an increase in the cooling pressure of CO2, the peak value of the heat transfer coefficient of CO2 decreases and the average heat transfer coefficient decreases; with an increase in the mass flux of CO2, the peak value of the heat transfer coefficient of CO2 increases and the average heat transfer coefficient increases; and with a decrease in the channel radius of CO2, the peak value of the heat transfer coefficient of CO2 increases. The water mass flux has only a slight effect on heat transfer, and the lower cooling pressure of CO2 corresponds to a higher peak heat transfer coefficient, which can reach 27.5 kW∙m−2∙K−1 at 9 MPa.
CFD Analysis and Optimum Design for a Centrifugal Pump Using an Effectively Artificial Intelligent Algorithm
Authors: Wang Chia-Nan , Yang Fu-Chiang , Nguyen Van Thanh Tien , Vo Nhut T. M.
Published: August 2022

In this study, we proposed a novel approach to improve centrifugal pump performance with regard to the pump head, pump efficiency, and power. Firstly, to establish constraints, an optimal numerical model that accounted for factors such as pump efficiency and the head was considered. The pump was designed, and an artificial intelligence algorithmic approach was applied to the pump before performing experiments. We considered a set of models by selecting the parameters of the centrifugal pump casing section area, the interference of the impeller, the volute tongue length, and the volute tongue angle. The weights of the factors of safety and displacement on the optimization indices were estimated. The matrix of the weights for the optimal process was less than 38% or greater than 62%. This approach guarantees a complicated multi-objective optimization problem. The results show that the centrifugal pump performances were improved.
Sequential Covariance Intersection Fusion Robust Time-Varying Kalman Filters with Uncertainties of Noise Variances for Advanced Manufacturing
Authors: Qi Wenjuan , Wang Shigang
Published: August 2022

This paper addresses the robust Kalman filtering problem for multisensor time-varying systems with uncertainties of noise variances. Using the minimax robust estimation principle, based on the worst-case conservative system with the conservative upper bounds of noise variances, the robust local time-varying Kalman filters are presented. Further, the batch covariance intersection (BCI) fusion and a fast sequential covariance intersection (SCI) fusion robust time-varying Kalman filters are presented. They have the robustness that the actual filtering error variances or their traces are guaranteed to have a minimal upper bound for all admissible uncertainties of noise variances. Their robustness is proved based on the proposed Lyapunov equations approach. The concepts of the robust and actual accuracies are presented, and the robust accuracy relations are proved. It is also proved that the robust accuracies of the BCI and SCI fusers are higher than that of each local Kalman filter, the robust accuracy of the BCI fuser is higher than that of the SCI fuser, and the actual accuracies of each robust Kalman filter are higher than its robust accuracy for all admissible uncertainties of noise variances. The corresponding steady-state robust local and fused Kalman filters are also presented for multisensor time-invariant systems, and the convergence in a realization between the local and fused time-varying and steady-state Kalman filters is proved by the dynamic error system analysis (DESA) method and dynamic variance error system analysis (DVESA) method. A simulation example is given to verify the robustness and the correctness of the robust accuracy relations.
Electroplated Al Press Marking for Wafer-Level Bonding
Authors: Al Farisi Muhammad Salman , Tsukamoto Takashiro , Tanaka Shuji
Published: August 2022

Heterogeneous integration of micro-electro mechanical systems (MEMS) and complementary metal oxide semiconductor (CMOS) integrated circuits (ICs) by 3D stacking or wafer bonding is an emerging approach to advance the functionality of microdevices. Aluminum (Al) has been of interest as one of the wafer bonding materials due to its low cost and compatibility with CMOS processes. However, Al wafer bonding typically requires a high temperature of 450 °C or more due to the stable native oxide which presents on the Al surface. In this study, a wafer bonding technique for heterogeneous integration using electroplated Al bonding frame is demonstrated. The bonding mechanism relies on the mechanical deformation of the electroplated Al bonding frame through a localized bonding pressure by the groove structures on the counter wafer, i.e., press marking. The native oxide on the surface was removed and a fresh Al surface at the bonding interface was released through such a large mechanical deformation. The wafer bonding was demonstrated at the bonding temperatures of 250–450 °C. The influence of the bonding temperature to the quality of the bonded substrates was investigated. The bonding shear strength of 8–100 MPa was obtained, which is comparable with the other Al bonding techniques requiring high bonding temperature.
Electrodeposition as a Tool for Nanostructuring Magnetic Materials
Authors: Ruiz-Gómez Sandra , Fernández-González Claudia , Perez Lucas
Published: August 2022

Electrodeposition has appeared in the last year as a non-expensive and versatile technique for the growth of nanomaterials. We review the main characteristics of electrodeposition that make this technique very suitable for its combination with different nanofabrication tools and the possibilities that this combination offers to fabricate nanowires and more complex tridimensional nanostructures. Finally, we overview the present and future impact of electrodeposition on the fabrication of a novel generation of nanomaterials with potential impact in nanomagnetism and spintronics.
A Portable ‘Plug-and-Play’ Fibre Optic Sensor for In-Situ Measurements of pH Values for Microfluidic Applications
Authors: Kumar Rahul , Nguyen Hien , Rente Bruno , Tan Christabel , Sun Tong , Grattan Kenneth T. V.
Published: August 2022

Microfluidics is used in many applications ranging from chemistry, medicine, biology and biomedical research, and the ability to measure pH values in-situ is an important parameter for creating and monitoring environments within a microfluidic chip for many such applications. We present a portable, optical fibre-based sensor for monitoring the pH based on the fluorescent intensity change of an acrylamidofluorescein dye, immobilized on the tip of a multimode optical fibre, and its performance is evaluated in-situ in a microfluidic channel. The sensor showed a sigmoid response over the pH range of 6.0–8.5, with a maximum sensitivity of 0.2/pH in the mid-range at pH 7.5. Following its evaluation, the sensor developed was used in a single microfluidic PDMS channel and its response was monitored for various flow rates within the channel. The results thus obtained showed that the sensor is sufficiently robust and well-suited to be used for measuring the pH value of the flowing liquid in the microchannel, allowing it to be used for a number of practical applications in ‘lab-on-a-chip’ applications where microfluidics are used. A key feature of the sensor is its simplicity and the ease of integrating the sensor with the microfluidic channel being probed.
Flotation Separation of Covellite and Enargite via Oxidation Treatment
Authors: Gan Yonggang , Deng Rongdong , Liu Quanjun
Published: August 2022

The flotation separation of enargite from copper sulfide minerals is difficult owing to the similar floatability and reagent adsorption characteristics of these minerals. In this study, the effect of oxidation treatment using NaClO flow with FeCl3 on the flotation separation of covellite and enargite was systematically investigated. Micro-flotation tests and contact angle measurements indicated that the addition of NaClO and FeCl3 increased the hydrophobicity difference between covellite and enargite. The bench-scale flotation test results show that the bulk copper concentrate could be separated into two products: a low-arsenic-containing (0.46%) and a high-arsenic-containing (5.18%) copper concentrate. X-ray photoelectron spectroscopy and scanning electron microscopy revealed that the oxidization treatment of NaClO caused the accumulation of oxides on the covellite surface, but not on the enargite surface. The varying precipitation of ferric hydroxide on the surfaces of covellite and enargite further exacerbated the difference in the hydrophilicity of these minerals. Thus, a possible method for separating enargite from covellite was obtained through oxidation treatment using NaClO and FeCl3.
Study on the Basic Characteristics of Iron Ore Powder with Different Particle Sizes
Authors: Li Zezheng , Li Yifan , Duan Yuanshuai , Yang Aimin , Xu Zhenghan , Zhi Jianming
Published: August 2022

In order to study in depth the differences in basic characteristics between iron ore fines commonly used by a steel company, and guide the sintering performance plant to choose the best ore allocation method, experimental studies on the basic characteristics of seven iron ore powders of three sizes were carried out using micro-sintering equipment, mainly including assimilation properties, liquid phase fluidity, and bonding phase strength. The results of the research showed that with the increase of the iron ore powder particle size, the assimilation of the seven iron ore powders showed an overall decreasing trend, deteriorating fluidity and decreasing bonding phase strength. Among them, the overall fluidity of iron ore powder A was poor, and the fluidity of iron ore powder B varied greatly between different particle grades, and the fluidity of iron ore powder C was more balanced and its bonding phase strength was high, while the overall bonding phase strength of iron ore powders B and E was low. The results of the study provide a theoretical basis for optimal ore allocation in sintering plants.
Ore Genesis of the Dongping Gold Deposit in the Northern Margin of North China Craton: Constraints from In-Situ Major, Trace Elemental Analysis of Magnetite and Pyrite
Authors: Wang Chengyang , Yu Jiajia , Ren Yunsheng , Zhao Junkang , Sun Zhenjun
Published: August 2022

The Zhangxuan district in North China, also known as Northwestern Hebei “Golden Triangle,” develops many intrusion-hosted lode-gold deposits. The Dongping gold deposit in the Zhangxuan district is well known for its unique hosting of rocks and ore mineral assemblages. Magnetite and pyrite are common minerals that widely exist in ores of the Dongping deposit. To get a better understanding of the evolution of the ore-forming fluids responsible for mineralization, we report on an integrated study on the electron microprobe analysis (EMPA) and laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) analysis of magnetite and pyrite from the deposit. The major results are as follows: The magnetite grains from the Dongping deposit show a variable content of major and trace elements such as Ti, Al, Si, Fe, Mn, Cr, Na, V, and Co, and the majority of the magnetite contain low Ti contents, revealing potential properties of hydrothermal magnetite. The flat time-resolved signals of LA-ICP-MS imply that the majority of trace elements in magnetite exist in the form of isomorphism, except for some incompatible trace elements. Magnetites from the Dongping deposit have compositional characteristics of hydrothermal origins, and the genetic discriminant diagrams of Ti–V, Ti–Ni/Cr or (Ca + Al + Mn)–(Ti + V) show that they may be originated from magma differentiated hydrothermal solutions. Co, Ni in pyrite from Dongping mainly enter the lattice via isomorphism, and Cu, Zn, Ag, W, Sn, Au, Pb, and Bi are partitioned into pyrite as micro/nano- mineral inclusions. The Co, Ni content, and the Ni/Co ratios, indicated that the temperature of the ore-forming fluids has decreased from Py-1 to Py-2, and the enrichment of Au in Py-2 may be related to the cooling and boiling of the fluids.
Flower-like Highly Open-Structured Binder-Free Zn-Co-Oxide Nanosheet for High-Performance Supercapacitor Electrodes
Authors: Abbas Qasim , Siyal Sajid Hussain , Mateen Abdul , Bajaber Majed A. , Ahmad Awais , Javed Muhammad Sufyan , Martin Patrick , Joly Nicolas , Bocchetta Patrizia
Published: August 2022

Scientific research is being compelled to develop highly efficient and cost-effective energy-storing devices such as supercapacitors (SCs). The practical use of SC devices is hindered by their low energy density and poor rate capability due to the binding agents in fabricating electrodes. Herein, we proposed flower-like highly open-structured binder-free ZnCo2O4 micro-flowers composed of nanosheets supported in nickel foam (ZnCoO@NF) with improved rate capability up to 91.8% when current varied from 2 to 20 A·g−1. The ZnCoO@NF electrode exhibited a superior specific capacitance of 1132 F·g−1 at 2 A·g−1 and revealed 99% cycling stability after 7000 cycles at a high current density of 20 A·g−1. The improved performance of the ZnCoO@NF electrode is attributed to the highly stable structure of the micro/nano-multiscale architecture, which provides both the high conduction of electrons and fast ionic transportation paths simultaneously.