bluuebunny/crossref_metadata_2025 huggingface dataset:
Upaya Meningkatkan Hasil Belajar PPKn Materi Keberagaman Masyarakat Indonesia Dalam Bingkai Bhinneka Tunggal Ika Melalui Model Cooperative Learning Tipe STAD Pada Siswa Kelas IX D SMP Negeri 2 Salam Semester Genap Tahun Pelajaran 2021/2022
Authors: Istiwati Istiwati
Published: November 2022

Materi keberagaman masyarakat Indonesia dalam bingkai bhinneka tunggal ika merupakan salah satu materi yang sangat substansial untuk dikuasai oleh peserta didik dalam rangka mewujudkan salah satu tujuan khusus mata pelajaran PPKn yaitu peserta didik yang mampu berpikir kritis, rasional,kreatif serta memiliki semangat kebangsaan, cinta tanah air yang dijiwai oleh nilai-nilai Pancasila, UUD Negara Republik Indonesia Tahun 1945, semangat Bhinneka Tunggal Ika serta komitmen NKRI.Fakta dilapangan menunjukkan bahwa hasil belajar PPKn materi Keberagaman Masyarakat Indonesia dalam Bingkai Bhinneka Tunggal Ika pada kelas IXD SMP Negeri 2 Salam masih belum ideal.Untuk mengatasi permasalahan tersebut, guru melakukan penelitian tindakan kelas ( PTK ) dengan menggunakan model cooperative learning tipe Student Teams Achievement Division (STAD). Tujuan Penelitian tindakan ini adalah untuk meningkatkan hasil belajar peserta didik kelas IX D SMP N 2 Salam Tahun Pelajaran 2021/2022 menggunakan model cooperative learning tipe Student Teams Achievement Division (STAD).Subjek penelitian adalah peserta didik kelas IX D berjumlah 31 anak, sumber data penelitian diperoleh dari data kualitatif berupa data hasil observasi aktivitas guru dan peserta didik serta data kuantiatif berupa data tes hasil belajar peserta didik.Hasil penelitian siklus 1 menunjukkan ,peserta didik yang tuntas secara individu sebanyak 9 anak dengan ketuntasan klasikal sebesar 61,29%.Sedang hasil penelitian pada siklus II menunjukkan peningkatan yaitu dari jumlah peserta  sebanyak 31 anak , diperoleh data 28 peserta didik telah tuntas belajar dengan ketuntasan klasikal sebesar 90,32 %. Berdasarkan hasil penelitian tersebut menunjukkan pembelajaran dengan model cooperative learning tipe Student Teams Achievement Division (STAD) dapat meningkatkan hasil belajar peserta didik kelas IX D SMP Negeri 2 Salam Tahun Pelajaran 2021/2022.
Upaya Meningkatkan Hasil Belajar IPA Materi Getaran, Gelombang Dan Bunyi Melalui Metode Cooperative Learning Type Number Heads Together (NHT) Pada Siswa Kelas VIII D SMP Negeri 3 Pakis Tahun Pelajaran 2021/2022
Authors: Widiningsih Rahayu
Published: November 2022

Salah satu permasalahan dalam pembelajaran IPA (Ilmu Pengetahuan Alam) adalah kurangnya kemampuan siswa dalam menerapkan pengetahuan untuk menyelesaikan permasalah dalam kehidupan nyata terutama dalam menyelesaikan soal tentang getaran, gelombang, dan bunyi. Untuk mengatasi permasalah ini maka dilakukan penelitian tindakan kelas (PTK) menggunakan metode Cooperative Learning Type Number Heads Together ( NHT). Tujuan penelitian ini adalah untuk mengetahui peningkatan hasil belajar siswa kelas VIII D SMP  Negeri 3 Pakis Tahun Pelajaran 2021/2022 menggunakan metode Cooperative Learning Type Number Heads Together ( NHT). Subjek penelitian adalah siswa kelas VIII D berjumlah 28 siswa, sumber data penelitian diperoleh dari data kualitatif berupa data hasil observasi aktivitas guru dan siswa serta data kuantitatif berupa data nilai tes hasil belajar siswa. Hasil penelitian siklus I diperoleh siswa yang tuntas secara individu sebanyak 17 siswa dengan ketuntasan klasikal sebesar 60 %. Sedangkan siklus II, terjadi penigkatan . sebanyak 26 siswa  siswa memperoleh nilai tuntas KKM dengan presentase ketuntasan 92,9 %. Berdasarkan hasil penelitian tersebut, pembelajaran menggunakan Cooperative Learning Type Number Heads Together ( NHT) dapat meningkatkan hasil belajar siswa kelas VIII D SMP Negeri 3 Pakis Tahun Pelajaran 2021/2022.
Morphological features of the distribution of extracellular matrix components MMP-9 and type IV collagen in metastatic choroidal melanoma
Authors:   Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine, Chelyabinsk, Russia, Shamanova А.Yu. ,   South-Ural State Medical University, Chelyabinsk, Russia, Каzachkov Е.L. ,   South-Ural State Medical University, Chelyabinsk, Russia, Panova I.Е. ,   S.N. Fedorov National Medical Research Center Inter-Sectoral Research and Technical Complex Eye microsurgery, Saint Petersburg, Russia
Published: November 2022

Introduction. Early diagnosis and prediction of distant metastases in choroidal melanoma patients based on morphological and IHC assessment of the components of the tumor microenvironment is a topical issue. The aim was to evaluate the IHC expression of MMP-9 and type IV collagen in metastatic choroidal melanoma. Materials and methods. We analyzed 43 cases of choroidal melanoma T2(a,b,c)-3N0M0-1 during 2013–2017. The patients were divided into two groups: group 1 included patients with primary choroidal melanoma without distant metastases (N=25) and group 2 included patients with primary choroidal melanoma with distant liver metastases (N=18). We performed an IHC assay of the surgical samples with MMP-9 (Poly) (MMP-9) and Collagen-IV (Clone CIV 22) (Col4) antibodies. Qualitative, semi-quantitative, and quantita-tive parameters were evaluated with digital pathology software. We developed a semi-quantitative method for estimating the intensity of IHC expression of these markers (in scores) in choroidal melanoma. Results. The study included 22 female and 21 male patients (51.2% and 48.8%, respectively), the average age being 60.5 years. The thickness of choroidal melanoma averaged 8.3 mm; the average diameter of the tumor was 12.3 mm. We detected strong MMP-9 expression in tumor cells and their microenvironment and remodeled collagen framework in tumors with pronounced tumor necrosis, thickness, and scleral involve-ment. A more pronounced expression of MMP-9 was associated with an increase in isolated type IV collagen fibers in the extracellular matrix (ECM) of the metastatic choroidal melanoma. Conclusion. During the growth and progression of choroidal melanoma, the components of the microenvi-ronment and tumor cells have a mutual effect with the disorganization of ECM components. Indicators of IHC expression (MMP-9, Col4) in a tumor should not be considered as a diagnostic marker of metastatic choroidal melanoma. However, they can be used in clinical practice when monitoring the course of the disease and in studying the mechanisms of remodeling of the tumor microenvironment. Keywords: choroidal melanoma, MMP-9, type IV collagen, metastasis
Clinical and morphological features of localized laryngeal amyloidosis
Authors:   Avtsyn Research Institute of Human Morphology of FSBSI Petrovsky National Research Centre of Surgery, Moscow, Russia, Gioeva Z.V. ,   North Ossetian State Medical Academy of the Ministry of Health of Russia, Vladikavkaz, Russia, Vandysheva R.A. ,   Avtsyn Research Institute of Human Morphology of FSBSI Petrovsky National Research Centre of Surgery, Moscow, Russia, Ephiev A.A. ,   North Ossetian State Medical Academy of the Ministry of Health of Russia, Vladikavkaz, Russia, Gabueva A.A. ,   North Ossetian State Medical Academy of the Ministry of Health of Russia, Vladikavkaz, Russia, Dzadzieva N.G. ,   North Ossetian State Medical Academy of the Ministry of Health of Russia, Vladikavkaz, Russia, Erofeeva L.M. ,   Avtsyn Research Institute of Human Morphology of FSBSI Petrovsky National Research Centre of Surgery, Moscow, Russia, Mikhaleva L.M. ,   Avtsyn Research Institute of Human Morphology of FSBSI Petrovsky National Research Centre of Surgery, Moscow, Russia
Published: November 2022

Introduction. Amyloidosis is a disease characterized by extracellular deposition of insoluble fibrils composed of an abnormal protein, amyloid. This protein builds up in various tissues and organs and interferes with their function leading to atrophy and sclerosis. Amyloidosis is usually a systemic disease. However, there are case reports of localized amyloidosis. Localized laryngeal amyloidosis is a rare condition accounting for approximately 15% of localized amyloidosis. The aim of the research was to describe morphological features of localized laryngeal amyloidosis. Materials and methods. We analyzed clinical findings, biopsy, and surgical specimens of 6 patients with localized laryngeal amyloidosis. Amyloid deposits were detected in tissue sections with Congo red stain with polarized light microscopy. We performed immunohistochemical analysis with monoclonal and polyclonal antibodies to detect different amyloid types. Results. Laryngeal amyloidosis was diagnosed in 4 male and 2 female patients aged from 44 to 62 (the mean age was 54 years). We found amyloid deposits in the interstitial spaces and tumor-like masses; in polarized light, amyloid showed a bright apple-green birefringence. Inflammatory cell infiltrate and multinucleated giant cells were visualized in most cases. Based on the immunohistochemical typing results, 4 patients had AL-kappa amyloidosis and 2 patients were diagnosed with AL-lambda amyloidosis. The disease recurrence was reported in 2 cases. Conclusion. In the head and neck area, the larynx is the most common site affected by localized amyloidosis. AL-kappa amyloidosis prevailed in our study, most of them being in men. In view of high recurrence rates, a long-term follow-up is needed after the amyloid deposit excision. Keywords: amyloidosis, larynx, amyloidoma, localized amyloidosis, immunohistochemistry
Hepatocellular cancer. Current aspects of carcinogenesis
Authors:   National Medical Research Center for Oncology, Rostov-on-Don, Shaposhnikov A.V. , Kit O.I. ,   National Medical Research Center for Oncology, Rostov-on-Don, Nepomnyaschaya E.M. ,   National Medical Research Center for Oncology, Rostov-on-Don, Yurieva E.A. ,   National Medical Research Center for Oncology, Rostov-on-Don
Published: November 2022

The modern concept of general carcinogenesis is built on the basic knowledge of exogenous and endogenous factors. They change the body–organ–cell homeostatic and tissue basis and lead to genetic and molecular alterations followed by uncontrolled abnormal cell growth. We studied hepatocellular carcinoma (HCC) as an example of malignant neoplasm carcinogenesis. The article presents some major molecular and genetic alterations resulting in HCC as well as their association with immune microenvironment that mostly determines the onset and further tumor development. These are morphological, molecular, and genetic factors on which the HCC classification we propose is based. It involves 2 tumor classes (proliferating and nonproliferating) and will enable for determining the upcoming prospects for diagnosis of and treatment for this condition. Keywords: exogenous and endogenous risk factors, molecular and genetic and structural liver alterations, classification of hepatocellular carcinoma
Morphological features of the myocardium in LAMP2-cardiomyopathy
Authors:   Altai State Medical University, Barnaul, Russia, Motina N.V. , Veselovskaya N.G. ,   Altai State Medical University, Barnaul, Russia,   Altai Regional Cardiology Dispensary, Barnaul, Russia, Kostyuchenko G.I. ,   Regional Clinical Hospital, Barnaul, Russia, Ott A.V. ,   Altai State Medical University, Barnaul, Russia,   Altai Regional Cardiology Dispensary, Barnaul, Russia, Gervald V.Ya. ,   Altai State Medical University, Barnaul, Russia, Motin Yu.G. ,   Altai State Medical University, Barnaul, Russia,   Regional Clinical Hospital, Barnaul, Russia
Published: November 2022

We present a clinical and morphological case study of a delayed LAMP2-cardiomyopathy (Danon disease) in a 44-year-old woman. LAMP2-cardiomyopathy is caused by impaired autophagy processes due to lysosome-associated membrane protein-2 (LAMP-2) deficiency in cardiomyocytes. This is a rare and diagnostically challenging condition inherited in an X-linked dominant pattern. A medical triad includes myocardial damage with hypertrophic LAMP2-cardiomyopathy, intellectual disability, and skeletal myopa-thy, the first one being the most significant prognostic factor and the main cause of death in these patients. However, autophagy disturbance and lysosomal glycogen accumulation in cardiomyocytes often remain unrecognized as the cause of hypertrophic cardiomyopathy. The report briefly describes disease etiology and epidemiology and outlines the clinical findings of the morphological study focusing on intravital ultra-structural features of structural changes in the myocardium. We provide data from the patient’s history, the results of laboratory and imaging studies, as well as endomyocardial biopsy examination at the light-optical and electron microscopic levels. Keywords: Danon disease, hypertrophic cardiomyopathy, LAMP2, electron microscopy
Dampak Tarif Pajak Badan Terhadap Tax Avoidance dengan Kompetensi Komite Audit sebagai Variabel Moderasi
Authors: Handayani Mukti Eka , Rachmawati Nurul Aisyah
Published: November 2022

Alasan realisasi penerimaan pajak yang tidak memenuhi target penerimaan pajak karena kebijakan pemerintah yang kurang efektif. Selain itu perbedaan dari sudut pandang antara pemerintah dan wajib pajak, dimana tingkat kesadaran dan kepedulian masyarakat terhadap pajak sulit untuk diwujudkan. Sehingga sampai saat ini kesadaran masyarakat untuk membayar pajak belum tercapai sesuai dengan keinginan pemerintah. Tidak hanya masyarakat umum, namun perusahaan yang memilik NPWP Badan wajib membayar pajak. Tindakan penghindaran pajak yang dilakukan oleh wajib pajak dapat bersifat ilegal maupun legal. Tindakan yang bersifat ilegal disebut tax evasion sedangkan tindakan yang bersifat legal disebut tax avoidance. Penelitian ini bertujuan untuk menguji dan menganalisis dampak tarif pajak badan terhadap tax avoidance dengan kompetensi komite audit sebagai variabel moderasi. Penelitian ini menggunakan metode Regresi Data Panel dengan sampel penelitian dipeoleh sebanyak 62 perusahaan dari sektor pertambangan, material, dan pertanian yang terdaftar di Bursa Efek Indonesia (BEI) pada tahun 2019-2020. Hasil penelitian menunjukkan bahwa tarif pajak badan tidak berpengaruh terhadap tax avoidance dan kompetensi komite audit dapat memperlemah hubungan negatif antara tarif pajak badan dan tax avoidance.
Bukti Empiris Praktik Perpajakan Dan Pembukuan Atas Transaksi Kartu Kredit Pemerintah Di Indonesia
Authors: Sumantri Joko
Published: November 2022

Tulisan ini berupaya meneliti praktik yang diterapkan dalam pembayaran belanja pemerintah Indonesia menggunakan KKP (Kartu Kredit Pemerintah) yang dikaitkan dengan pemenuhan kewajiban bendahara pengeluaran. Dalam pembahasannya, peneliti mencoba memahami bagaimana praktik yang terjadi dan seharusnya dalam pemotongan pajak, penulisan kwitansi dan kelengkapan bukti pembayaran, dan mekanisme pembukuan yang dilakukan oleh bendahara pengeluaran dalam hal pembayaran dilakukan dengan KKP. Menggunakan metode penelitian kualitatif, kami mendapatkan beberapa temuan penelitian berupa terdapatnya beberapa skenario pemotongan pajak, peraturan yang menetapkan batas waktu berbeda untuk pemotongan dan penyetoran pajak, serta tekhnik pembukuan transaksi bendahara pengeluaran yang dimodifikasi untuk tujuan kepraktisan pada aplikasi SAKTI (Sistem Aplikasi Keuangan Tingkat Instansi).
Retrospective Voting Pada Pemilihan Kepala Daerah Di Indonesia: Akuntabilitas Keuangan dan Kinerja
Authors: Purwidayani Viranita , Slamet Kuwat
Published: November 2022

Penelitian ini bertujuan untuk mengetahui pengaruh akuntabilitas keuangan dan akuntabilitas kinerja terhadap elektabilitas petahana pada pemilihan kepala daerah Indonesia periode 2015-2018. Kami memasukkan 139 sampel dari berbagai kotamadya dan kota yang melakukan pemilihan kepala daerah selama jangka waktu tersebut. Opini audit dan temuan penyimpangan audit digunakan untuk mengukur akuntabilitas keuangan, sedangkan skor kinerja dan evaluasi akuntabilitas kinerja digunakan untuk mengukur akuntabilitas kinerja. Analisis data dilakukan dengan menggunakan Small Stata 14.2. Hasil penelitian menunjukkan bahwa temuan penyimpangan audit dapat menurunkan elektabilitas petahana secara signifikan, sedangkan opini audit, skor kinerja dan evaluasi akuntabilitas kinerja tidak berpengaruh signifikan terhadap elektabilitas petahana.
Empirical Realities of Teacher-Child Interaction and Cognitive Development of Pre-Primary School Children In Ibadan, Oyo State
Authors: Ikie Rosemary Nmadinobi , Amosun Moses Dele , Olalowo Iyanuoluwa Emmanuel
Published: November 2022

The characteristics of teacher-child interaction play a paramount role in the cognitive development of children. Despite its significance, literature abounds on how these characteristics, such as teachers' actions, words, gestures, and responsibilities, may improve or deter children’s development (Grosse, 2022; Bartholo et al., 2022). Thus, this study was carried out to contribute to the body of knowledge, particularly taking into account preschools from a developing nation such as Nigeria. It sought to establish the extent and influence of teacher-child interaction on the cognitive development of pre-primary children in the Ibadan metropolis. The study employed a correlational survey design. A multi-stage approach was used for sampling and sampling. The total sample size for the study was 200, which comprised 50 pre-primary class teachers and 150 pre-primary school children. Two research questions were raised and answered. Teacher-Child Interaction Observation Schedule (TCIOS) = 0.72, Child Cognitive Development Rating Scale (CCDRaS) = 0.79, and Questionnaire on Teacher’s Perception of Teacher-Child Interaction on Cognitive Development (QTPTCICD) = 0.80 were the instruments used for the study. Data collected were analysed using descriptive statistics and Pearson Product Moment Correlation. The result of the findings revealed that the extent of teacher-child interaction and level of cognitive development was great with = 3.41and  = 3.61, respectively, as well as the teachers' perceived influence on teacher-child interaction on cognitive development, was positive (  = 3.16). Although the finding showed no significant relationship between teacher-child interaction and cognitive development (r=0.01; p>0.05), it is recommended that teachers, however, should maintain the positive, quality interaction that characterizes preschool teaching, which may resonate with other uniqueness and educational needs of the child.
Improving Mathematical Critical Thinking Skill through STEM-PjBL: A Systematic Literature Review
Authors: Setyawati Rina Dwi , Pramasdyahsari Agnita Siska , Astutik Iin Dwi , Aini Sindi Nur , Arum Julia Puspita , Widodo Wahyu , Nusuki Ukima , Salmah Ummy , Zuliah Nafiatuz
Published: November 2022

Critical thinking is one of the important competencies in the twenty-first century that should be acquired. Therefore, there is a need to facilitate the students with the teaching approach and learning model that could improve this skill. One of the learning approaches that provide the students with the opportunity to think creatively is STEM-PjBL. Therefore, the purpose of the study is to describe the application of STEM-PjBL able to increase the critical thinking skills of the student. The SLR or Systematic Literature Review method was chosen to present a comprehensive and balanced summary of primary research results. The literature review was conducted through Google Scholar, Crossref, and Scopus. From 100 works of literature, 15 articles showed that PjBL STEM learning was able to improve critical thinking skills. This study examined 15 articles that were analyzed based on research methods, and the findings revealed that the application of STEM-PjBL could enhance the critical thinking skills of the student with the literature review method. Based on the existing data collection, it is analyzed through case studies that are the subject of discussion. The findings of the study revealed that: 1) the use of STEM-PjBL had a positive and significant impact on the critical thinking skills of students in each educational unit, including primary school, secondary schools, and high school; 2) the use of STEM-PjBL can help students improve their mathematical critical thinking skills; 3)  interpretation, analysis, inference, evaluation, explanation, and self-regulation are among the indicators recommended for use as a reference for students' mathematical critical thinking skills.
РИТОРИЧНА ПІДГОТОВКА СТУДЕНТІВ СПЕЦІАЛЬНОСТІ «КУЛЬТУРОЛОГІЯ» В УМОВАХ ДИСТАНЦІЙНОГО НАВЧАННЯ
Authors: Будянський Дмитро
Published: November 2022

Підготовка сучасного фахівця в умовах дистанційного навчання вимагає нових підходів та рішень. Це стосується і студентів спеціальності «Культурологія», зокрема розвитку їх риторичної культури, яку можна аргументовано вважати однією із головних професійно-необхідних якостей. Використання переваг дистанційного навчання, риторичного потенціалу культурологічних дисциплін, застування сучасних педагогічних технологій в комплексі сприятимуть підвищенню рівня риторичної культури майбутнього культуролога.
Для вирішення поставленої проблеми було застосовано наступні методи: аналіз наукової, культурологічної, психолого-педагогічної і методичної літератури, систематизація, спостереження, порівняння та узагальнення.
У даному дослідженні розглянуто зміст і специфічні риси риторичної культури культуролога, проаналізовано переваги і недоліки дистанційної форми навчання для розвитку цієї якості студентів спеціальності «Культурологія», обґрунтовано доцільність використання сучасних педагогічних технологій з цією метою. Визначені майбутні перспективи дослідження цієї проблематики.
Проведене дослідження дозволило сформулювати наступні висновки. Риторична культура є однією із провідних професійних якостей фахівця цієї галузі. У зв’язку з цим, здійснено аналіз стану риторичної підготовки студентів спеціальності «Культурологія». Визначено, що наразі розвитку цієї якості приділяється недостатньо уваги, що обумовлює необхідність використання сучасних педагогічних технологій, інтенсифікації практичної роботи риторичного характеру, застосування переваг дистанційного навчання тощо. Наголошується, що сучасні технології, медіаплатформи, соціальні мережі можуть бути використані як ефективні інструменти риторичної підготовки майбутнього культуролога.
Differential expression of STYK1 in amyotrophic lateral sclerosis.
Authors: Mamoor Shahan
Published: November 2022

Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines sporadic ALS using published data (3, 4). We found significant differential expression of STYK1, encoding serine/threonine/tyrosine kinase 1, in induced pluripotent stem cell (iPSC)-derived motor neurons of patients with ALS. STYK1 was also differentially expressed in fibroblasts isolated from patients with ALS. STYK1 transcript was present at significantly higher levels in ALS iPSC-derived motor neurons. These analyses will begin to define the transcriptional landscape of ALS.
PEMBIMBING KE DALAM PERJANJIAN BARU
Authors: Restu Toya
Published: November 2022

Buku ini sangat cocok bukan hanya bagi para mahasiswa teologi, tetapi juga setiap orang yang berminat pada dunia Perjanjian Baru. Meskipun ditulis dengan menggunakan kajian Ilmiah yang sistematia, buku ini tetap disajikan dalam bahasa yang sederhana sehingga dapat dipahami oleh setiap warga gereja-Nya.
Can language influence health decisions? The role of foreign language and grammatical structure
Authors: Alkhammash Reem , Asiri Yousif A. , Alqarni Ibrahim R. , Al-Hoorie Ali H.
Published: November 2022

The language used to present an argument has long been argued to influence people’s reaction to that argument. This study examined how language and grammatical structure influenced response to health-related dilemmas. We investigated whether medical students’ willingness to receive a medical treatment or to take an action (regarding advancing one’s own health or other people’s health) was influenced by the language (first versus foreign) and the grammatical structures (modifiers and quantifiers) used. Saudi medical students (N = 368) read health-related dilemmas using different adverbial modifiers and quantifiers in Arabic or in English. The participants were randomly assigned to one of four conditions: Arabic with high certainty (i.e., very-modifier and all-quantifier), Arabic with low certainty (no very-modifier and some-quantifier), English with high certainty, and English with low certainty. The results showed that the participants were susceptible to a foreign language effect, but not to a grammatical structure effect. We discuss the implications of these results in relation to how different health-scenarios may affect decision making for health professionals.
Differential expression of CYP2B6 in amyotrophic lateral sclerosis.
Authors: Mamoor Shahan
Published: November 2022

Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines sporadic ALS using published data (3, 4). We found significant differential expression of CYP2B6, encoding cytochrome P450 family 2 subfamily B member 6, in iPSC-derived motor neurons of patients with ALS. CYP2B6 was also differentially expressed in primary lower motor neurons isolated from patients with ALS. CYP2B6 transcript was present at significantly lower levels in ALS iPSC-derived motor neurons. These analyses will begin to define the transcriptional landscape of ALS.
Pentingnya Aplikasi Kredit Pintar Sebagai Media Pelayanan dan Kebutuhan Masyarakat menggunakan metode 7C Framework
Authors: Sandyawan
Published: November 2022

Dalam setiap kebudayaan selalu terdapat ilmu pengetahuan atau sain dan teknologi, yang digunakan sebagai acuan untuk menginterpretasikan dan memahami lingkungan beserta isinya, serta digunakan sebagai alat untuk mengeksploitasi, mengolah dan memanfaatkannya untuk pemenuhan kebutuhan manusia. Kredit Pintar adalah aplikasi yang menyediakan layanan pinjaman uang online untuk mendukung inklusi keuangan dengan nama badan usaha PT. Kredit Pintar Indonesia yang telah berdiri sejak tahun 2018. Kredit Pintar telah terdaftar dan diawasi oleh OJK, sehingga dinyatakan sebagai penyedia layanan pinjaman uang online yang resmi beroperasi di Indonesia.Memilih pinjaman online terpercaya membutuhkan ketelitian dan kecermatan. Sebagai pencari dana, wajar kiranya jika membandingkan satu layanan dengan layanan lain untuk memperoleh pinjaman bunga paling rendah dan menguntungkan. Salah satu layanan yang dapat kita pilih dalam memenuhi kebutuhan keuangan ialah pinjaman Kredit Pintar. Saat ini Kredit Pintar tidak hanya menjadi trend pinjam meminjam saja namun telah berdampak terhadap perekonomian dan mendorong terciptanya jenis pembiayaan dan investasi bagi masyarakat di seluruh Indonesia. Jadi metode yang digunakan dalam penelitian ini adalah menggunakan metode 7C Framework.
Elly Sugianto Angguna-UAS/Semester 3 Pastoral Konseling
Authors: Angguna Elly Sugianto
Published: November 2022

TIMOTIUSAyah Timotius adalah seorang Yunani, tetapi ibunya seorang Yahudi. la bertobat pada usia kurang lebih lima belas tahun, ketika Rasul Paulus mengunjungi kota asalnya, Listra (Kis. 16:1-3; 1Tim. 1:2). Tujuh tahun kemudian ia ikut dalam pelayanan penginjilan Paulus dan terjalinlah hubungan persahabatan yang sangat erat antara Paulus yang saat itu sudah berumur kira-kira tujuh puluh tahun dengan rekannya yang lebih muda.Setelah pemenjaraan Paulus yang pertama, ia mengunjungi beberapa tempat antara lain Efesus, dan karena tidak dapat lama berada di sana ia meninggalkan Timotius untuk memikul pelayanan di sana. Ketika ditinggal sendirian Timotius mendapatkan ujian yang sangat berat, karena sebelumnya ia sangat bergantung kepada nasihat Paulus. Sifatnya agak pemalu dan peka. Paulus menulis surat kepadanya dari Korintus untuk mendorong dia dan memberikan beberapa nasihat.Ayat kunci kitab ini adalah 3:15. Paulus sangat ingin melihat anak rohaninya memenuhi tanggung jawabnya sebagai seorang pemimpin Kristen. Ia berkeinginan supaya dalam segala hal Timotius dapat memberi teladan kepada jemaat yang mengharapkan kepemimpinannya (4:12)
UPACARA ADAT HABBO KA'O RAI.. SARA NARAKAHA
Authors: Narakaha Sara
Published: November 2022

Catatan upacara adat HABBO KO'O RAI pada masyarakat Sabu Raijua
TARIAN KEBALAI PULAU ROTE
Authors: Baleng Wirce Grasela
Published: November 2022

Tarian kebalai dari pulau rote yang memiliki makna menghibur orang yang berduka, dan di lakukan pada saat upacara-upaca adat.
Differential expression of KIAA1456 in amyotrophic lateral sclerosis.
Authors: Mamoor Shahan
Published: November 2022

Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines ALS using published data (3, 4). We found significant differential expression of KIAA1456 in iPSC-derived motor neurons of patients with ALS. KIAA1456 was also differentially expressed in the skeletal muscle of patients with ALS. KIAA1456 transcript was present at significantly higher levels in ALS iPSC-derived motor neurons as compared to control motor neurons. These analyses will begin to define the transcriptional landscape of ALS.
Vocabulary learning through videos: captions, advance-organizer strategy, and their combination
Authors: Teng Mark Feng
Published: November 2022

This study intended to examine L2 young learners’ vocabulary learning (i.e. form, meaning, and use). The research design involved a 2 (advance-organizer strategy: present vs. absent) × 4 (caption type: glossed full captions, glossed keyword captions, full captions, keyword captions) between-subjects design. A total of 240 Chinese ESL primary school students were recruited and randomly and equally assigned to eight conditions. Findings revealed that captioned videos produced significant effects on learning regarding the three dimensions of vocabulary knowledge. Glossed full captions were found to be the most effective caption type. Administration of the advance-organizer strategy also resulted in better gains in learning form, meaning, and use than the absence of this strategy. The combination of the advance-organizer strategy and glossed full captions led to the best learning performance for each dimension of vocabulary knowledge. Relevant pedagogical implications, including use of the advance-organizer strategy and captions, are provided.
Actions vs. Words: Exploring the contributions of working memory and motoric coding in children’s instruction following using a dual-task paradigm
Authors: Makri Angie , Fiske Abigail
Published: November 2022

Previous research in adults has showed that physical performance (i.e., enactment) of instructions at recall leads to better memory compared to verbal recall and that this effect does not rely solely on Working Memory resources. The current study aimed to replicate this finding in children. A group of 32 children encoded simple instructions verbally while engaging in a series of concurrent tasks (articulatory suppression, backwards counting and a motor suppression task). Participants recalled information verbally or physically through enactment. The findings showed that although concurrent tasks impaired performance compared to a control condition (no concurrent task), the enactment advantage remained intact in all conditions. These findings show that children’s memory is superior when they perform, rather than when they verbally repeat instructions and crucially it is suggested that this effect does not rely solely on Working Memory resources.
Jeunes, Communication & Climat. Diversité des enjeux climatiques auprès des 15-24 ans en Belgique
Authors: Ducol Loup , Anciaux Amélie , Catellani Andrea , Lits Grégoire , Galand Benoit , Nils Frédéric , Rihoux Benoît , Cougnon Louise-Amélie
Published: November 2022

Comment les jeunes Belges envisagent-ils leur avenir ? Fil conducteur de cette recherche, cette question nous permet d'interroger les perspectives d'une jeunesse diverse. Ces perspectives touchent à la fois leur compréhension et leur perception des phénomènes associés aux changements climatiques, leurs manières de s'informer sur la question, ainsi que leur vision concernant l'éducation qu'ils ont reçue et l'avenir que leur réserve le marché du travail.Pour appréhender empiriquement ces questions, une double enquête de terrain a été conduite. Une première partie quantitative a permis de dégager des tendances de pratiques et de perceptions des différentes catégories de jeunes prétriés selon des critères sociodémographiques. Une seconde partie qualitative a permis d'affiner ces données grâce à des focus groups sondant l'opinion des jeunes Belges les plus précaires. Ce travail de terrain confirme la pertinence de considérer une grande diversité au sein du groupe social « jeune » (15-24 ans), puisque des différences considérables sont observées, notamment entre les catégories socioéconomiques, mais aussi entre les classes d'âge.Pour dépasser ces constats et approfondir l'analyse segmentée des jeunes, des personae ont été constitués. Ainsi, sept profils de jeunes exclusifs les uns des autres sont dégagés, non pas dans l’objectif de ranger les jeunes dans des cases, mais pour proposer des solutions personnalisées en fonction de leurs différentes pratiques et valeurs.Les résultats de cette recherche permettent la formulation de recommandations concernant aussi bien les perspectives de communication climatique à l'égard des jeunes que les perspectives politiques à mettre en oeuvre pour encourager leur participation. Ces recommandations sont formulées de manière générale, mais aussi spécifiquement pour chaque persona identifiée. Enfin, les recommandations émanant autant des jeunes eux-mêmes que des experts ayant réalisé l’étude.
Unfulfilled promises: Tensions in mission statements of for-profit colleges and universities
Authors: Winfield Jake D. , Beckowski Catherine Pressimone
Published: November 2022

While collegiate missions of non-profit institutions have been extensively studied, missions of for-profit colleges in the United States have received less attention. This study examines the mission statements of 98 degree-granting for-profit colleges to articulate how these colleges describe their educational purposes. Our content analysis found that these institutions emphasize post-graduation opportunities and outcomes while also describing the curricula available, highlighting the contradictions of promoting access while seeking profit. We advance a deeper understanding of these institution’s self-ascribed purposes so that policymakers can ensure adequate student protections at for-profit colleges.
Individual Investors in the Nepalese Securities Market: What They Know and What They Like
Authors: Dahal Rewan Kumar
Published: November 2022

Investments in financial assets is getting much more popular nowadays. The investment made by individual investors is always guided by their own comprehension and preference over the investment. Therefore, the study aimed to examine the understating and the preference of the individual investors of the Nepalese securities market. A convenient sampling strategy was employed to obtain the essential information via structured questionnaire survey from investors at different stock brokers' sites in Kathmandu valley and collected 203 responses. Nepalese investors favoured equities and the banking sector. Even though profit was their major investing goal, they did not do a risk-return analysis. They were unhappy with investment decisions, rules, and regulations. As a result, their investing decisions were significantly influenced by their presumption of market information and understanding. This study has aided to a better comprehension of what factors contribute to shaping the individual investors' investment decisions.
SEMANTIC ANALYSIS OF THE CATEGORY «INNOVATIONS IN AGRICULTURAL BUSINESS»
Authors: Zaporozhets Dmitry
Published: November 2022

Introduction. Sustainable development of the domestic economy is possible only under the condition of an innovative way of its development, in this regard, one of the serious tasks is to identify promising directions for the development of socio-economic systems. This article discusses the tools for determining the strategic directions of socio-economic and innovative development. The purpose of this study is to develop a methodological approach to determining promising directions for the development of socio-economic systems using big data technology. Methodology. The work uses the tools of system analysis, semantic and content analysis. Results. Based on the conducted benchmarking, trends in the development of approaches to determining innovative directions of economic systems development are analyzed, a content analysis of the terms of the semantic field "innovations in agricultural business" is carried out, an approach to searching and processing big data and determining strategic directions for the development of economic systems is tested. Conclusions. The proposed methodology, combining expert methods with Data Mining technologies and Big Data analysis, will allow us to accurately determine the current trends in the development of the processes under study and identify the vectors of their innovative development.
Pengaruh Kualitas Pelayanan Terhadap Kepuasan Wisatawan Di Taman Indonesia Kaya Semarang
Authors: Suhartapa Suhartapa
Published: November 2022

ABSTRACTThe purpose of this study was to determine the effect of service quality which includes variables of reliability, responsiveness, assurance, empathy, and physical evidence on tourist satisfaction at Taman Indonesia Kaya tourism objects in Semarang.The research population is tourist visitors at Taman Indonesia Kaya Semarang. The number of research samples used were 92 respondents. Sampling used nonprobability sampling and convenience sampling methods. Data analysis used descriptive analysis and Multiple Linear Regression analysis. The study concluded that based on the t-test on the service quality variables at Taman Indonesia Kaya, it had a positive and significant effect on tourist satisfaction. The results of the F test simultaneously obtained a value of 27,668 significance floor 0.000 <0.05, indicating a significant influence between the variables of reliability, responsiveness, assurance, empathy, physical evidence on tourist satisfaction. The coefficient of determination (R²) of the five service quality variables on tourist satisfaction is 0.617, which indicates that 61.7% of tourist satisfaction is influenced by service quality, while 38.3% of tourist satisfaction is influenced by other variables outside the service quality variable. Keywords: Service Quality, Tourist Satisfaction
Identitas Kultural Masyarakat Suku Anak Dalam (ORANG RIMBA) (Studi Analisis Film Dokumenter Orang Rimba "The Life of Suku Anak Dalam")
Authors: Triana Dewi , Eka Putri Yuniar
Published: November 2022

Indonesia memiliki keberagaman budaya dan suku bangsa, masing-masing suku memiliki identitas kulturalnya sendiri. Namun sebagaimana Indonesia dikenal sebagai negara multikultur, suku yang mencapai ribuan tersebut dapat tetap hidup berdampingan dan harmonis (keterpaduan sosial). Salah satu suku bangsa yang selalu menarik untuk dibahas adalah Suku Anak Dalam atau Orang Rimba. Orang Rimba merupakan suku minoritas yang mendiami hutan Taman Nasional Bukit Duabelas, Provinsi Jambi dan sebagian Provinsi Sumatera Selatan. Meski terdapat tekanan modernisasi dan budaya global, namun suku Anak Dalam tetap mempertahankan budaya tradisionalnya. Tulisan ini menjabarkan identitas kultural suku Anak Dalam melalui film dokumenter " The Life of Suku Anak Dalam " yang tayang melalui channel Youtube Orang Rimba - The Life of Suku Anak Dalam. Film dokumenter tersebut memberikan penggambaran mendetail melalui wawancara langsung dengan tokoh dan penduduk asli suku Anak Dalam dalam aktifitas kesehariannya. Makna terpenting dalam kearifan lokal yang dianut suku Anak Dalam adalah aturan dan pedoman hidup yang dianut turun menurun dengan keselarasan, keseimbangan, dan keasrian hutan yang merupakan bagian dari leluhurnya dan sumber kehidupan mereka. Tiga hal utama identitas kultural yang dibahas dalam tulisan ini mencakup budaya pernikahan, kelahiran, dan kematian dalam ritual adat yang erat dengan nilai kearifan lokalnya.
Analisis Problematika Putusan Tata Usaha Negara Dalam Sengketa Kepegawaian
Authors: Rahman Muhammad Sabir , N.K Muhammad Luthfi
Published: November 2022

Penelitian ini dimaksudkan untuk mengetahui pertimbangan hakim dan penerapan hukum hakim terhadap perselisihan ketenagakerjaan dalam putusan nomor: 102/G/2019/PTUN.Mks. Jenis penelitian yang digunakan dalam penelitian ini adalah penelitian hukum normatif yang dianalisis dengan metode kualitatif analisis dekripsi. Sumber bahan hukum yang digunakan, bahan utama terdiri dari peraturan perundang-undangan, catatan resmi seperti naskah akademik dan risalah rapat peraturan perundang-undangan, dan keputusan peradilan baik negara maupun Mahkamah Agung, dan bahan hukum sekunder adalah hukum yang menjelaskan tentang bahan hukum primer. bahan hukum dari semua dokumen tidak resmi. Penerbitan undang-undang tersebut meliputi buku-buku tekstual dan tulisan-tulisan ilmiah yang berhubungan dengan benda-benda ilmiah. Hasil penelitian dapat disimpulkan bahwa Majelis Hakim sangat teliti pada aspek substansi yang tidak dapat diabaikan, karena kesalahan terdakwa dalam menghadirkan suatu objek yang dipersengketakan dengan keras dan bertentangan dengan prinsip-prinsip umum pemerintahan yang baik dalam pelanggaran asas ketelitian, bahwa gugatan penggugat atas pembatasan objek a quo harus dipenuhi. Majelis hakim telah menerapkan landasan hukum yang baik dalam putusannya, sehingga obyek perkara a quo telah dijatuhkan secara yuridis
Perlindungan Hukum Terhadap Hak-Hak Konsumen Yang Membeli Produk Makanan Kadaluwarsa
Authors: Rahwindi Pangestu Nugroho Putri  , Sri Wahyuni  , Rabiah Al Adawiah
Published: November 2022

Undang-Undang Dasar Negara Republik Indonesia Tahun 1945 dalam pasal 1 ayat 3 menyatakan bahwa Negara Indonesia merupakan negara hukum, artinya semua warga negara dan penyelenggara hukum pun harus tunduk kepada hukum yang berlaku. Pada Era globalisasi dan perdagangan saat ini telah banyak yang bermunculan bermacam produk makanan yang dipasarkan kepada konsumen di supermarket, promosi iklan maupun penawaran langsung. Fakta-fakta konsumen di kalangan masyarakat masih banyak yang dirugikan oleh produsen atau pelaku usaha seperti produk makanan yang sudah kadaluwarsa dijual ke konsumen. Adanya pelaku usaha yang menjual produk makanan kadaluwarsa dapat merugikan hak-hak konsumen atas kenyamanan, keamanan, keselamatan dalam mengkonsumsi barang dan jasa serta merugikan dari aspek kesehatan. Penelitian ini bertujuan untuk meneliti perlindungan hukum terhadap hak-hak konsumen dan ganti rugi terhadap konsumen serta mengetahui tanggung jawab pelaku usaha yang menjual produk makanan kadaluwarsa. Jenis penelitian yang digunakan dalam penelitian ini adalah hukum normatif dengan menggunakan data sekunder. Pendekatan yang digunakan adalah pendekatan perundang-undangan (statute aprroach) dan pendekatan kasus (case approach).
FINTECH ECOSYSTEM OF INDIA
Authors:   Institute of oriental studies, Russian academy of sciences (MOSCOW), Kandalintsev Vitaly
Published: November 2022

The article examines the structure of the fintech ecosystem of India, the interaction of ecosystem participants, factors of its rapid development. The significant role of government initiatives in the formation of digital infrastructure and support for startups is noted, the segments of the financial services market in India are analyzed in detail.
CORRELATION BETWEEN PERIODONTAL HEALTH INDICES AND PECULIARITIES OF CIRCADIAN RHYTHM IN BUCCAL EPITHELIAL CELLS
Authors: Vasko M.Yu. , Tkachenko I.M.
Published: November 2022

There is a complex system of biological rhythms arranging the coordinationion of physiological functions and the environmental rhythms. The leading place it taken by the circadian rhythm, a 24-hour cycle that is a part of the body's internal clock. Circadian regulation of normal physiological and metabolic processes is carried out by the fluctuations in the expression of genes (clock-controlled genes (CCGs)) and the proteins they encode, which differ in each individual organ or tissue. The circadian rhythm of gene expression was detected in the basal cells of the oral epithelium, in the cells of ameloblasts and odontoblasts, cells of the dental pulp, cells of the periodontal ligament, osteoblasts and osteoclasts of the alveolar bone. However, so far little is known about the dependence of clock controlled gene expression on chronotype in buccal epithelial cells.

The purpose of the study is to determine the expression level of the clock controlled genes Per1, Cry1, Bmal1 and Clock in the buccal epithelial cells of healthy people with different chronotype.

Materials and methods. In order to achieve the goal we surveyed 14 people (7 men (50%) and 7 women (50%) aged from 36 to 45 years with a healthy periodontium without any somatic pathology or with compensated one. All participants signed an informed consent forms. The chronotype of the participants was determined by the Horn-Ostberg test modified by S.I. Stepanova and determined the mRNA expression of Clock, Bmal1, Per1 and Cry1 in buccal epithelium samples at 7:00 am and 7:00 pm in one day in the autumn-winter period.

Results. The Per1 is better expressed early in the morning than in the evening, regardless of the chronotype (р1<0.05). The level of Clock expression is higher in the evening in both groups (р1<0.05). The difference between the indicators of the evening expression of the Clock in the two groups is statistically significant (р2<0.05). Bmal1 expression is higher in the evening, regardless of chronotype (р1<0.05). The Cry1 shows the same evening predominance among participants of both chronotypes, but it is not statistically significant.

Conclusion. The study has revealed the correlation between chronotype and the evening expression of the Clock that is higher in people with the evening chronotype. Belonging to the morning or evening chronotype did not reveal any effect on the expression level of Per1, Bmal1 and Cry1.