bluuebunny/crossref_metadata_2025 huggingface dataset:
REGISTERED OUTBREAKS OF ACUTE VIRAL HEPATITIS A IN STARA ZAGORA REGION, FOR THE PERIOD SEPTEMBER 2019 – MARCH 2020, IN THE MUNICIPALITIES BR. DASKALOVI, HRISHTENI, GALABOVO IN BULGARIA
Authors: Simeonova I. , Perchemlieva T. , Petrova St. , Trifonov G. , Iliev G. , Mladenova I.
Published: November 2021

Viral hepatitis type A is an acute infectious disease, occupying 75% of all viral hepatitis.
Purpose of the study was to investigate three outbreaks, of viral hepatitis A in the municipalities of Stara Zagora region, from 09.2019-03.2020 in schools and kindergartens.
Methods: We investigated all cases from viral hepatitis A, for the municipalities of Bratya Daskalovi-26, Hrishteni-19, Galabovo-21. A retrospective analysis and descriptive epidemiological methods have been used.
Results: The gender distribution shows that men were affected in 56% and women in 44%. The children in the age group of 5-9 years - 49%, as well as of 1 - 4 years - 19.7% are most ill. The peak in the development of the outbreaks is in December 2019 (18%) and January 2020 (48%), which lasts until March with the so-called "Epidemic tail". Contact persons were not covered by the hepatitis A vaccine. The faecal-oral mode of transmission of infection has been proven. Specialized companies were engaged for the activities of current and final disinfection. Health educational activities aimed at improving hygiene habits have been carried out.
Conclusion: To prevent the outbreaks the cases have to be timely reported; Early examination of contact persons; Applications of a vaccine on the contact persons.
BED BUG BITES ON ATHLETES
Authors: Valtchev V. , Chalakov M.
Published: November 2021

PURPOSE: Determine the number of athletes bitten by bed bugs and the location of the bite. METHODOLOGY: The diagnosed cases based on clinical anamnesis and examination by a dermatologist. RESULTS: 80 athletes (25 women and 55 men), aged 21 to 24, were investigated. All of them were complaining of itching and rash. After the clinical anamnestic information was collected and the dermatological examination performed, rashes because of bed bug bites were found in 55 of the subjects studied. The diagnosed lesions were linearly or annularly grouped and some of them have had a characteristic hemorrhagic center at the location of the bite. CONCLUSION: There is very little information on the frequency of bed bug bites in athletes in the available literature. This aroused our interest to present this material, which based on registered bed bug bites in athletes specializing in football. Bed bug bites and the accompanying skin irritation, which leads to unpleasant itching, impair the quality of human life.
LEMNA MINOR L. AS A SOURCE OF ANTIOXIDANTS
Authors: Petrova-Tacheva V. , Ivanov V. , Atanasov A.
Published: November 2021

Lemna Minor L. (LM) is a perennial aquatic plant that belongs to the genus Lemna, the family Lemnaceae and is spread almost ubiquitously. In folk medicine, it is used in the treatment of allergies, asthma, vitiligo, jaundice, glaucoma, rheumatism, gout, and others. In recent years it has become clear that its chemical composition consists of: proteins (up to 35%), vegetable fibers (up to 17%), fats (up to 5%), polysaccharides, flavonoids, amino acids, aliphatic acids, phenolic acids, triterpene compounds, vitamins, micro- and macro-elements and other substances. А significant part of these substances exhibit the antioxidant activity. The scientific information for 12 biologically active substances with antioxidant activity isolated from Lemna Minor is presented in the review.
Biodiversity of Zygosaccharomyces species in food systems
Authors: Péter G.
Published: November 2021

Abstracts

Zygosaccharomycesspecies are among the most problematic food spoilage yeasts. The two most infamous species areZygosaccharomyces baliiandZygosaccharomyces rouxii, although they may also take a positive role during the production of some fermented foods. DNA sequence based yeast identification aided by freely available reference databases of barcoding DNA sequences has boosted the description rate of novel yeast species in the last two decades. The genusZygosaccharomyceshas been considerably expanded as well. Especially the number of the extremely osmotolerantZygosaccharomycesspecies, related toZ. rouxiiand regularly found in high-sugar foods, has enlarged. A brief account of recent developments in the taxonomy and biodiversity of this important food associated genus is given in this review.
Conversa com os editores
Authors: Higuet Etienne Alfred
Published: November 2021

conversa
Religião como linguagem: Uma filosofia da religião para a Ciência da Religião
Authors: Alves da Silva André Luiz
Published: November 2021

O presente artigo busca apresentar uma proposta de filosofia da religião que procure se apresentar não como filosofia religiosa, mas como uma filosofia que sendo tanto crítica quanto fundamento para o estudo do fenômeno religioso, se constitua como metateoria da Ciência da Religião. Para isso propõe-se a perspectiva da religião como linguagem. O itinerário problematiza as filosofias religiosas comprometidas com teologias específicas, passa pelo giro linguístico como um ganho conceitual da filosofia na discussão da linguagem que perpassa todo fenômeno cultural, inclusive a religião e a Ciência da Religião e finaliza propondo uma análise dos fenômenos religiosos a partir de seus jogos de linguagem, tendo como marco teórico principal a inflexão do giro linguístico pragmático de Ludwig Wittgeinstein.
Indelével como a flor: A teofania da Virgem Maria aos olhos e ouvidos de Cartola
Authors: Passos de Souza Antonio , Calvani Carlos Eduardo Brandão , Machado Glaucio José Couri
Published: November 2021

No rastro do interesse despertado no âmbito das Ciências da Religião no Brasil pela presença de abordagens que se aproximam de temas religiosos em canções não religiosas, o presente artigo visa a focalização de uma nuance em meio a esse cancioneiro: canções criadas e divulgadas em contextos artísticos e comerciais sem vínculos com instituições religiosas, porém, com uma profundidade teológica e caracterização que as coloca como que aspirantes à condição de música religiosa de uma determinada confissão. O artigo baseia-se em estudos recentes sobre aspectos religiosos da MPB, escritos a partir de elementos da teologia da cultura de Tillich. O texto apresenta algumas canções ligadas a devoções marginais do catolicismo popular, bem como a devoções marianas, concentrando-se posteriormente em uma análise específica do samba “Dê-me Graças, Senhora”, uma composição incorporada ao repertório do sambista Cartola, lançada originalmente no álbum “Cartola 70 Anos” (1979). A análise demonstra que a aproximação entre canções não religiosas e temas religiosos pode se dar de modo explícito com a citação expressa de símbolos religiosos ou de forma mais sutil, implícita, por meio de uma inserção discursiva da canção em reflexões basilares para a teologia e a religião
A Bíblia em Mangá: perspectiva tillichiana sobre a nona arte
Authors: Alvarenga Leonardo Gonçalves de , Gomes Nataniel Dos Santos , Alvarenga Monique Mattos Azevedo , Sabra Fernando Glória Caminada
Published: November 2021

Este artigo faz uma transposição das análises de Paul Tillich para nona arte. As escolhas de Tillich orientam-se, de preferência, para a cultura erudita, ao invés da cultura de massa, o kitsch. Mas dos tempos de Tillich até hoje a arte ganhou novas formas e reconhecimentos. As HQs estão nesta lista. Especificamente trouxemos o Mangá, que faz parte da cultura japonesa e possui traços muito peculiares. Dentre os temas abordados, o Mangá tem sido uma ferramenta de comunicação de elementos religiosos cristãos. O objetivo, portanto, é, a partir dos níveis de relação entre arte e religião elaborados por Paul Tillich fazer uma análise da Bíblia em Mangá, da série NEXT, publicada no Brasil em 5 volumes.
Reflection and transmission of P-waves at a very rough interface between two isotropic elastic solids
Authors: Vinh Pham Chi , Tung Do Xuan , Kieu Nguyen Thi
Published: November 2021

This paper deals with the reflection and transmission of P-waves at a very rough interface between two isotropic elastic solids. The interface is assumed to oscillate between two straight lines. By mean of homogenization, this problem is reduced to the reflection and transmission of P-waves through an inhomogeneous orthotropic elastic layer. It is shown that a P incident wave always creates two reflected waves (one P wave and one SV wave), however, there may exist two, one or no transmitted waves. Expressions in closed-form of the reflection and transmission coefficient have been derived using the transfer matrix of an orthotropic elastic layer. Some numerical examples are carried out to examine the reflection and transmission of P-waves at a very rough interface of tooth-comb type, tooth-saw type and sin type. It is found numerically that the reflection and transmission coefficients depend strongly on the incident angle, the incident wave frequency, the roughness and the type of interfaces.
Cross-genera amplification and identification of Colpodella sp. with Cryptosporidium primers in fecal samples of zoo felids from northeast China
Authors: Hussain S. , Li X. , Bukhari S. M. , Zhou M. , Ahmad S. , Ahmad S. , Javid A. , Guan C. , Hussain A. , Ali W. , Khalid N. , Ahmad U. , Tian L. , Hou Z.
Published: November 2021

Abstract The protozoans include many intracellular human pathogens. Accurate detection of these pathogens is necessary to treat the diseases. In clinical epidemiology, molecular identification of protozoan is considered a more reliable and rapid method for identification than microscopy. Among these protozoans, Cryptosporidium considered being one of the important water-borne zoonotic pathogens and a major cause of a diarrheal disease named cryptosporidiosis in humans, domestic animals, and wild animals. This study was aimed to identify Cryptosporidium in zoo felids (N= 56) belonging to different zoo of China, but accidentlly Colpodella was encountered in the zoo felids sample and phylogenetic data confirmed this unexpected amplification from fecal samples using two-step nested-PCR. Phylogenetic analysis revealed the fact about the specific primers used previously by many researchers and cross-genera amplification. We came to know that genetically sequenced amplicon gives more accurate identification of species. This study suggests more investigation on Colpodella which has been neglected previously but gains the attention of researchers after identified from humans and animals and has been known to correlate with neurological symptoms in patients.
First report of two Aspergillus species isolated from mangrove forest in Ecuador
Authors: Sacheri-Viteri Katheryn , Fernandez-Cadena Juan Carlos , Molina-Moreira Natalia , Andrade-Molina Derly
Published: November 2021

Mangroves forests are located in tropical and subtropical regions, its adaptation and distribution in coastal regions is influenced by temperature, humidity, tidal and saline fluctuations. Therefore, there are exposed to multiple environmental fluctuations. Mangroves are inhabited by wildlife but also is supported by a diverse community of microorganisms, including fungi. Several fungi in mangroves have multiple ecological roles as saprotrophs or as an opportunistic pathogen, many of them are also used in the industry, as the genus Aspergillus, that are important in the biomedicine, industrial and environmental applications. In this study we isolated species of fungi from mangrove stems and propagules. They were identified by both morphological and by its molecular characteristics.  Here, we report the first isolated of Aspergillus niger and Aspergillus aculeatus from mangrove in Ecuador. Research such as these highlights the importance to determine the role of fungi in mangrove ecosystem.
Efficacy and safety of endovascular arteriovenous fistula creation with comparison to surgically created fistulas: a systematic review and meta-analysis protocol v4
Authors: Shimamura Yoshinosuke
Published: November 2021

This systemic review and meta-analysis aimed to evaluated existing evidence on the clinical efficacy and safety of endovascular arteriovenous fistula creation by directly comparing it with surgical arteriovenous fistula creation among patients with chronic kidney disease requiring hemodialysis.
Method for detecting acetylated PD-L1 in cell lysates v1
Authors: Middleton-Davis Frances
Published: November 2021

Here we present a method that allows detection of acetylated PD-L1 and is applicable to a wide range of cell lines. The method captures >90% of acetylated PD-L1 species, is semi-quantitative and simple to perform in any lab equipped with tissue culture and western blot equipment. The method involves processing cells in a lysis buffer that has been optimized for efficient immunoprecipitation (IP) of acetylated species, an IP enrichment step utilizing an acetyl-lysine affinity matrix and western blot detection of both total and acetylated PD-L1 on the same blot. This technique compliments the alternative IP approach utilizing a PD-L1 antibody as the IP reagent and an anti-acetyl lysine antibody as the detection reagent. However, because the protocol described here enables the detection of both total and acetylated PD-L1 on the same blot, this method has the advantage of allowing quantitation of the percent of PD-L1 that is acetylated, an important parameter for mechanistic interpretation. The method described here utilizes beads that are covalently linked to the affinity antibody, resulting in extremely clean IP results. Western blots can be re-probed with a pan anti-acetyl lysine antibody to visualize the total protein acetylation profile in any given lysate, a property that is useful when examining PD-L1 acetylation in the presence of HDAC inhibitors or other treatments affecting global acetylation.
Environmental DNA sampling protocols for the surveillance of marine non-indigenous species v3
Authors: Mirimin Luca , Miller Dulaney , Fernandez Sara
Published: November 2021

This document describes a series of protocols for the collection of environmental samples intended for the monitoring and surveillance of marine invasive species by means of eDNA metabarcoding analysis, as described in the associated publication (Fernandez et al. 2021: https://doi.org/10.1016/j.marpolbul.2021.112893).
Creating Planet Microbe Data Packages v1
Authors: Blumberg Kai , J J. Ponsero Alise , Hurwitz Bonnie
Published: November 2021

Marine microbial ecology requires the systematic comparison of biogeochemical and sequence data to analyze environmental influences on the distribution and variability of microbial communities. With ever-increasing quantities of metagenomic data, there is a growing need to make datasets Findable, Accessible, Interoperable, and Reusable (FAIR) across diverse ecosystems. FAIR data is essential to developing analytical frameworks that integrate microbiological, genomic, ecological, oceanographic, and computational methods. Although community standards defining the minimal metadata required to accompany sequence data exist, they haven't been consistently used across projects, precluding interoperability. Moreover, these data are not machine-actionable or discoverable by cyberinfrastructure systems. By making ‘omic and physicochemical datasets FAIR to machine systems, we can enable sequence data discovery and reuse based on machine-readable descriptions of environments or physicochemical gradients. In this work, we developed a novel technical specification for dataset encapsulation for the FAIR reuse of marine metagenomic and physicochemical datasets within cyberinfrastructure systems. This includes using Frictionless Data Packages enriched with terminology from environmental and life-science ontologies to annotate measured variables, their units, and the measurement devices used. This approach was implemented in Planet Microbe, a cyberinfrastructure platform and marine metagenomic web-portal. Here, we discuss the data properties built into the specification to make global ocean datasets FAIR within the Planet Microbe portal. We additionally discuss the selection of, and contributions to marine-science ontologies used within the specification. Finally, we use the system to discover data by which to answer various biological questions about environments, physicochemical gradients, and microbial communities in meta-analyses. This work represents a future direction in marine metagenomic research by proposing a specification for FAIR dataset encapsulation that, if adopted within cyberinfrastructure systems, would automate the discovery, exchange, and re-use of data needed to answer broader reaching questions than originally intended.
TRENDS IN THE SPREAD OF FROST DEPOSITS OF THE CATEGORY DP (DANGEROUS PHENOMENA) ON THE TERRITORY OF UKRAINE DURING THE LAST THIRTY YEARS 1991-2020
Authors: Pyasetska S.I.
Published: November 2021

The article is devoted to the study of spatio-temporal distribution of DP (dangerous phenomena) frost deposits on the territory of Ukraine during the last 30 years, which characterize the current state and dynamics of the climate system in Ukraine and its individual elements. The aim of the study was to establish the features of spatio-temporal distribution of such sediments in the regions of Ukraine for individual decades of the study period and to outline the trend in their distribution. some increase in the incidence of such deposits in some months of the transition seasons. For the last decade, there has been an increase in such cases in January and December compared to previous decades. However, during the last 2 years the number of cases of frost deposits of the DP (dangerous phenomena) category has slightly decreased. It is proved that the vast majority of such cases were observed in Transcarpathia at the meteorological station Play, which is associated with a higher frequency of favorable conditions for its formation.
Given the results of the study, we can say that in 1991-2000 the largest number of cases of frost deposits of the category of DP in Ukraine was observed in January, February and December, with January accounting for the vast majority of cases.
During January, frost deposits of the DP category were quite widely represented on the territory of Ukraine in 9 oblasts. During February and March, they were observed only in mountainous areas – in Transcarpathia and in the Autonomous Republic of Crimea. In April, October and November, such deposits were observed only in Transcarpathia at the Play meteorological station. In December, their range expanded and they were observed not only in the mountains, but also in the north, northeast and east of the country in 5 regions.
The largest number of such cases during 1991-2000 was observed in Transcarpathia (Play) and in the Autonomous Republic of Crimea (Ai-Petri).
In the period 2001-2010, the main number of cases of frost deposition of the DP (dangerous phenomena) category falls on the months of the cold period of the year, especially January and December. In contrast to the period 1991-2000, the number of cases increased in March and November, and the number of such deposits increased slightly in April.
The vast majority of cases of frost deposits of the DP (dangerous phenomena) category during 2001-2010, as well as in the previous decade, were observed in Transcarpathia at the Play weather station.
During 2011-2020, there was an increase in the number of cases of DP frost deposits in January and February compared to 2001-2010 and a slight decrease in these deposits in November and December. Also for this period, a greater localization of such sediments in Transcarpathia was established in all the studied months compared to the previous study periods, when especially in January and December such sediments were quite widespread in Ukraine.
Review of "One Database at at Time: PubMed for Expert Searchers and Systematic Reviews” Webinar
Authors: Quesenberry Wilson Alexandria
Published: November 2021

As the interest in systematic review expertise grows, the Medical Library Association Technology in Education and the Systematic Review Caucuses came together to co-sponsor a series called “One Database at a Time” that examines and discusses how to use a different database for systematic searches. The first session, focused on the PubMed database, was offered on March 23. Moderated by Margaret Foster and led by panelists Alyssa Grimshaw, Liz Suelzer, and LaTeesa James, the session covered a variety of topics, from building your systematic search in PubMed to systematic review software.
Projective Assessment of Surgery Drawings Created by Children with and without Surgery
Authors: SEYİS Semra , GÜLEÇ Serap , ORAK Oya Sevcan
Published: November 2021

The study aimed to perform a projective assessment of surgery drawings created by children with and without surgery. The study had a descriptive design and included 40 children aged 7-12 years and followed in pediatric surgery clinic of a hospital in Turkey. Out of 40 children, 20 had surgery and 20 did not have surgery. Both qualitative and quantitative data collection and assessment techniques were used. Data were gathered with a child descriptive characteristics form and surgery drawings. The drawings were evaluated by using projective analysis. The projective analysis of the drawings revealed three themes, i.e., fear, perceived body integrity and surgical room image. Perceived body integrity had a significant relation with having the experience of surgery (P0.05). In this study, the surgery drawings created by the children with and without the experience of surgery were examined through projective assessment and their perceptions about surgery were compared. The children undergoing surgery were found to have less fears but more negative perceptions about the body integrity and negative surgical room image.
HUBUNGAN TRANSFORMATIONAL LEADERSHIP SERTA PERAN EXCHANGE NORM DAN COMMUNAL NORM TERHADAP EMPLOYEE VOICE DALAM INDUSTRI SWASTA DI JABODETABEK [RELATIONSHIP BETWEEN TRANSFORMATIONAL LEADERSHIP AND THE ROLE OF EXCHANGE NORM AND COMMUNAL NORM WITH EMPLOYEE VOICE IN PRIVATE INDUSTRY IN JABODETABEK]
Authors: P.W. Maria Yolandita , Barry Rinto Rain
Published: November 2021

This study aims to determine whether transformational leadership, exchange norm, and communal norm have a positive relationship with employee voice. This study was shown to private employees of the banking industry with 133 respondents consisting of 98% male respondents and 2% female respondents. The instrument used for data collection is a questionnaire, which consists of 13 indicators. Testing of the questionnaire was carried out by means of a validity test which resulted in sig < α (0.000 < 0.05) and a reliability test which resulted in Cronbach's Alpha > 0.7. Furthermore, the tool used in analyzing the data is IBM SPSS 25. The results of this study reveal that transformational leadership has a positive relationship with exchange norm, transformational leadership has a positive relationship with communal norm, transformational leadership has a positive relationship with employee voice, norm exchange has a positive relationship with employee voice, and communal norm have a positive relationship with employee voice.
TALENT MANAGEMENT LITERATURE REVIEW
Authors: Singh Rajesh Prettypal
Published: November 2021

The concept of talent management has attracted most of the researchers’ attention in the recent years. In today’s business environment, talent management becomes one important source of competitive advantage that creates value for all companies. In the current economic downturn, there is a high demand for talent in the organizations. The aim of this study is to examine talent management process in organizations. This article is based on a review of the academic and popular talent management literatures. The paper focused by clarifying the definitions and the importance of talent management and what factors influencing the growth of talent management.
SHIFTING ORIENTATION IN COMPETITION FROM PROFIT TO PEOPLE QUALITY: INFLUENCE OF SERVICE QUALITY, PRODUCT, SATISFACTION ON CUSTOMER LOYALTY OF A FASTFOOD RESTAURANT IN JAKARTA
Authors: Fery Fery , Sembel Jacquelinda Sandra
Published: November 2021

In fast-food industry, food quality and safety become pre-requisite to launch a fast-food restaurant. Thus, the players in this industry offer similar quality of food. This has caused a shift of the focus of competition in the industry from competing in the quality of product to the quality of human resources in serving customers. The aim of this study is to find out whether service quality, product, and satisfaction have any impact on customer loyalty. The study surveyed 30 respondents in the pre-testing and 170 respondents in actual data testing. SmartPLS3.2 software was used to process data, that was collected using questionnaire. Data processing was conducted using validity test, reliability test, multiple regression analysis and hypothesis testing. The test revealed that Service Quality is indeed an important variable to affect Customer Loyalty. The same result applied to Product and Satisfaction what also revealed positive effect on Customer Loyalty.
UNIVERSITY STRATEGY AND IMPLEMENTATION USING THE DAVID STRATEGIC-MANAGEMENT MODEL: A CASE STUDY FROM INDONESIA
Authors: Kho Ardi , Rumanti Elisabeth Dewi , Sudibjo Niko , Nanda Kezia Arya
Published: November 2021

The competency standards of university graduates must comply with the National Standards of Education, the Indonesian National Qualification Framework (KKNI), and other criteria set by the university. Universities need to set strategies and implementations to achieve the standard of graduate competence consisting of attitudes, knowledge, and skills stated in the formulation of graduate learning achievements. A case study using a qualitative approach was conducted at the university in Banten, Indonesia. The purpose of this study is to explore academic strategies in university. This includes examining the key drivers for strategic planning, the opportunities pursued in strategic planning, and challenges encountered in the process of strategic planning. The findings suggest that key drivers for strategic planning in the university include market competition and customer requirements. Secondly, the findings are the university should pursue three major strategic planning opportunities, including improved academic operational efficiency, improved student competency, and lecturer’s qualification, as well as improved services of the university. Thirdly, the change management process is reactive and not necessarily transformational in its degree, even though it can involve large-scale changes. The findings integrated into a model contribute to understanding the relationship between the context of strategic planning, the content of strategic planning, and the process of strategic planning in university.
EKSPLORASI PERBEDAAN DAN INTERAKSI IMMERSION DAN FLOW DALAM VIRTUAL RUN EVENT [EXPLORATION OF THE DIFFERENCES AND INTERACTIONS BETWEEN IMMERSION AND FLOW IN VIRTUAL EVENT RUNS]
Authors: Kiesa Celine , Nathanael Nevio , Saragih Harriman Samuel , Jayawardhana Irman
Published: November 2021

This study aims to explore the differences between flow and immersion experiences and find the relationship between individual flow and immersion experiences in virtual run events. This research is qualitative research that uses narrative methods towards individuals by using interview for collecting information. The target of this study is the virtual run event participants from the period May–June 2021. This study involves informants who are sought through social media and personal relationships of the researchers. The search for informants was assisted by snowball sampling to be able to find informants who met the criteria. The results of this study found differences between flow and immersion and also the interaction between flow and immersion.

BAHASA INDONESIA ABSTRAK

Penelitian ini bertujuan untuk mengeksplorasi perbedaan pengalaman flow dan immersion dan juga mencari keterkaitan antara pengalaman flow dan immersion individu dalam virtual run event. Penelitian ini merupakan penelitian kualitatif yang menggunakan metode riset naratif terhadap individunya dengan menggunakan teknik wawancara dalam menggali informasinya. Target dari studi ini adalah peserta virtual run event dari periode Mei–Juni 2021. Studi ini melibatkan informan yang dicari melalui media sosial dan relasi pribadi dari peneliti. Pencarian informan dibantu dengan snowball sampling untuk dapat menemukan informan yang memenuhi kriteria. Dari hasil studi ini ditemukan perbedaan antara flow dan immersion dan juga interaksi antara flow dan immersion.
The effect of gender agreement mismatches on intersentential anaphoric pronouns
Authors: Soares Eduardo Correa , Mota Mailce Borges
Published: November 2021

This article focuses on the effect of gender agreement mismatches between personal pronouns and their antecedents across sentences. In two acceptability experiments, we test whether acceptability of gender agreement violations on animated nouns may be modulated by grammatical and contextual features of the antecedents of personal pronouns. In the first experiment, we manipulated the “specificity” feature of the antecedent in order to make the antecedent refer either to the class of individuals or to a specific referent. In the second experiment, we used stereotypically male or female proper names to test whether grammatical gender mismatches between personal pronouns and bigender nouns could be attenuated. Although the first experiment showed an effect explainable purely by grammatical factors, against many theories of “semantic” agreement, the results of the second experiment suggest that both the grammatical and the contextual features of the antecedent are computed when speakers evaluate agreement relations between personal pronouns and their antecedents.
LIVELIHOOD ASSETS OF FISH FARMERS IN TIWINGAN LAMA VILLAGE
Authors: Setiawan Faisal Arif , Hastuti Karunia Puji , Rahman Akhmad Munaya , Alviawati Eva
Published: November 2021

During 2019 the Riam Kanan Reservoir had a decrease in water level due to drought. As a result, the income of fish farmers has decreased. This study aims to determine the livelihood assets of fish farmers as long as the pond does not provide maximum income. The research sample is fish farmers as many as 90 respondents. Livelihood Asset Questionnaire refers to DFID. The results showed that the livelihood assets of fish farmers had natural capital of 66, physical capital of 62, human capital of 42, financial capital of 14, and social capital of 11. Attention to financial and social capital needed to be increased to reduce social vulnerability in fish farming families.
DEVELOPMENT OF ONLINE CONTEXTUAL LEARNING MODELS USING A SCIENTIFIC APPROACH
Authors: Tivi Beta
Published: November 2021

This study aims to describe the science-based contextual learning model applied in kindergarten in North Banjarbaru District during the pandemic, by adopting the type of development research. The tool used in this research is a science-based contextual learning tool developed by the researcher, so the tool must be tested before being used. Based on the findings, it is known that so far teachers have not designed learning tools according to the 2013 curriculum, where in the curriculum there are six aspects of development that must be carried out, including aspects of religious and moral values, social emotional, cognitive, language, physical motor, and art. . Where in presenting the themes and sub-themes, it must refer to these six aspects by presenting them in an integrated manner, it means linking the indicators developed in these aspects related to the sub-themes that have been selected or determined. The learning implementation plan made by the teacher only contains an assessment sheet in the form of a checklist, while to find out all aspects of child development, several assessment techniques are needed when the teacher provides learning and observes children while in the school environment.
MPROVEMENT OF ELEMENTARY SCHOOL TEACHERS IN CLASSROOM ACTION RESEARCH TOWARDS PROFESSIONALISM AND EXCELLENCE IN LABUAN DISTRICT, PANDEGLANG REGENCY, BANTEN PROVINCE
Authors: Sudrajat Ajat , Darojat Ojat , Mikdar Syaeful
Published: November 2021

Tujuan dilaksanakannya Pengabdian Pada Masyarakat ini adalah pemahaman guru terkait penelitian Tindakan kelas menjadi lebih meningkat sehingga guru nanti dengan mudah membuat penelitian sederhana yang terjadi di dalam kelasnya. Metode yang digunakan dalam Pengabdian Pada Masyarakat ini adalah 1) Metode ceramah; penyajian  materi pelajaran  yang dilakukan  oleh  Narasumber  dengan  penuturan  atau penjelasan  secara   langsung   dihadapan peserta  workshop. 2) Metode Diskusi; cara penyampaian suatu materi pelajaran melalui sarana pertukaran pikiran untuk memecahkan persoalan yang dihadapi. 3) Pemberian Tugas, secara berkelompok, peserta menganalisis secara kualitatif contoh proposal Penelitian Tindakan Kelas yang diberikan oleh narasumber kemudian secara berkelompok peserta berlatih membuat proposal Penelitian Tindakan Kelas. Hasil pelaksanaan Pengabdian Pada masyarakat ini adalah Hasil Penilaian Ketercapaian Program dari jumlah peserta 25 guru memberikan tanggapan positif sebanyak 100% yang memiliki nilai penambahan keilmuan guru di Kecamatan Labuan Kabupaten Pandeglang Provinsi Banten. Sedang kepuasan mitra kerjasama yaitu PGRI Kecamatan Labuan terhadap pelaksanaan PkM dosen FKIP Universitas Terbuka menyatakan 100% menyatakan sangat puas dan bernilai tinggi dalam rangka mengembangan kualitas sumber daya manusia dalam hal ini adalah guru sebagai pengajar di Kecamatan Labuan.
Sagacious Epitope Selection for Vaccines, and Both Antibody-Based Therapeutics and Diagnostics: Tips From Virology and Oncology
Authors: Gan Samuel Ken-En , Phua Ser-Xian , Yeo Joshua Yi
Published: November 2021

The target of an antibody plays a significant role in the success of antibody-based therapeutics and diagnostics, and to an extent, that of vaccine development. This importance is focussed on the target binding site – epitope, where epitope selection as a part of design thinking beyond traditional antigen selection using whole cell or whole protein immunisation can positively impact success. With purified recombinant protein production and peptide synthesis to display limited/selected epitopes, intrinsic factors that can affect the functioning of resulting antibodies can be more easily selected for. Many of these factors stem from the location of the epitope that can affect accessibility of the antibody to the epitope at a cellular or molecular level, direct inhibition of target antigen activity, conservation of function despite escape mutations, and even non-competitive inhibition sites. Through the incorporation of novel computational methods for predicting antigen changes to model-informed drug discovery and development, superior vaccines and antibody-based therapeutics or diagnostics can now be more easily designed to mitigate failures. With detailed examples, this review highlights the new opportunities, factors and methods of predicting antigenic changes for consideration in sagacious epitope selection.
Financial Technology in Financial Inclusions and its Implications on Poverty from Indonesia
Authors: Aba Fransiskus , Linardy Denise
Published: November 2021

The goal is to reduce poverty, the method used is a literature study to see the effect of using Financial Technology (Fintech) on financial inclusion, method to see the effect of financial inclusion on poverty. From the results of the tests, the use of Fintech can increase financial inclusion, thereby encouraging poverty alleviation. It can be seen that the Financial Inclusion variable has a significant and negative effect on the poverty variable. This shows that countries that have high levels of financial inclusion are generally estimated to have low poverty rates. Increasing a country's financial inclusion can reduce poverty.
Inactivity of Peptidase ClpP Causes Primary Accumulation of Mitochondrial Disaggregase ClpX With Its Interactors at the Nucleoid and RNA Granule
Authors: Key Jana , Torres-Odio Sylvia , Bach Nina C. , Gispert Suzana , Koepf Gabriele , Reichlmeir Marina , West A. Phillip , Prokisch Holger , Freisinger Peter , Newman William G. , Shalev Stavit , Sieber Stephan A. , Wittig Ilka , Auburger Georg
Published: November 2021

Biallelic pathogenic variants in CLPP, encoding mitochondrial matrix peptidase ClpP cause a rare autosomal recessive condition, Perrault syndrome type 3 (PRLTS3). It is characterized by primary ovarian insufficiency and early sensorineural hearing loss, often associated with progressive neurological deficits. Mouse models showed that accumulations of (i) its main protein interactor, the substrate-selecting AAA+ ATPase ClpX, (ii) mitoribosomes, and (iii) mtDNA nucleoids are main cellular consequences of ClpP absence. However, the sequence of these events and their validity in human remain unclear. Here, we studied global proteome profiles to define ClpP substrates among mitochondrial ClpX interactors, which accumulated consistently in ClpP-null mouse embryonal fibroblasts and brain. Validation work included novel ClpP-mutant patient fibroblast proteomics. ClpX co-accumulated in mitochondria with POLDIP2 as nucleoid component, LRPPRC as mitochondrial poly(A) mRNA granule element, GFM1 (in mouse also GRSF1) as tRNA processing factors. Only in mouse, accumulated ClpX, GFM1 and GRSF1 appeared in nuclear fractions. Mitoribosomal accumulation was minor. Consistent accumulations in murine and human fibroblasts also affected multimerizing factors not known as ClpX interactors, namely OAT, ASS1, ACADVL, STOM, PRDX3, PC, MUT, ALDH2, PMPCB, UQCRC2 and ACADSB, but the impact on downstream metabolites was marginal. Our data demonstrate the primary impact of ClpXP on the assembly of proteins with nucleic acids, and show nucleoid enlargement in human as a key consequence.
Lamotrigine Attenuates Neuronal Excitability, Depresses GABA Synaptic Inhibition, and Modulates Theta Rhythms in Rat Hippocampus
Authors: Kazmierska-Grebowska Paulina , Siwiec Marcin , Sowa Joanna Ewa , Bartosz Caban , Kowalczyk Tomasz , Bocian Renata , MacIver M Bruce
Published: November 2021

Theta oscillations generated in hippocampal (HPC) and cortical neuronal networks are involved in various aspects of brain function, including sensorimotor integration, movement planning, memory formation and attention. Disruptions of theta rhythms are present in individuals with various disorders, including epilepsy and Alzheimer’s disease. Theta rhythm generation involves a specific interplay between cellular (ionic) and network (synaptic) mechanisms. HCN channels are theta modulators, and several medications are known to enhance their activity. We investigated how different doses of lamotrigine (LTG), an HCN channel activator, and antiepileptic and neuroprotective agent, would affect hippocampal theta rhythms in acute HPC slices (in vitro) and anaesthetized rats (in vivo). Whole-cell patch clamp recordings revealed that LTG decreased GABAA-fast transmission in CA3 and CA1 cells, in vitro. In addition, LTG directly depressed CA3 and CA1 pyramidal neuron excitability. These effects were partially blocked by ZD 7288, a selective HCN blocker, and are consistent with decreased excitability associated with antiepileptic actions. Lamotrigine also depressed hippocampal theta oscillations in vitro, also consistent with its neuronal depressant effects. In contrast, it exerted an opposite, enhancing effect, on theta recorded in vivo. The contradictory in vivo and in vitro results indicate that LTG increases ascending theta activating medial septum/entorhinal synaptic inputs that over-power the depressant effects seen in hippocampal neurons. These results provide new insights into LTG actions and indicate an opportunity to develop more precise therapeutics for the treatment of dementias, memory disorders and epilepsy.
The Artemiside-artemisox-artemisone-M1 Tetrad: Efficacies Against Blood Stage P. falciparum Parasites, DMPK Properties, and the Case for Artemiside
Authors: Gibhard Liezl , Coertzen Dina , Reader Janette , van der Watt Mariëtte E. , Birkholtz Lyn-Marie , Wong Ho Ning , Batty Kevin T , Haynes Richard K , Wiesner Lubbe
Published: November 2021

Because of the need to replace the current clinical artemisinins in artemisinin combination therapies, we are evaluating fitness of amino-artemisinins for this purpose. These include the thiomorpholine derivative artemiside obtained in one scalable synthetic step from dihydroartemisinin (DHA) and the derived sulfone artemisone. We have recently shown that artemiside undergoes facile metabolism via the sulfoxide artemisox into artemisone and thence into the unsaturated metabolite M1; DHA is not a metabolite. Artemisox and M1 are now found to be approximately equipotent with artemiside and artemisone in vitro against asexual P. falciparum (Pf) blood stage parasites (IC50 1.5 – 2.6 nM). Against Pf NF54 blood stage gametocytes, artemisox is potently active (IC50 18.9 nM early-stage, 2.7 nM late-stage). Comparative drug metabolism and pharmacokinetic (DMPK) properties were assessed via po and iv administration of artemiside, artemisox and artemisone in a murine model. Following oral administration, the composite Cmax value of artemiside plus its metabolites artemisox and artemisone formed in vivo is some 2.6-fold higher than that attained following administration of artemisone alone. Given that efficacy of short half-life rapidly-acting antimalarial drugs such as the artemisinins is associated with Cmax, it is apparent that artemiside will be more active than artemisone in vivo, due to additive effects of the metabolites. As is evident from earlier data, artemiside indeed possesses appreciably greater efficacy in vivo against murine malaria. Overall, the higher exposure levels of active drug following administration of artemiside coupled with its synthetic accessibility indicate it is much the preferred drug for incorporation into rational new artemisinin combination therapies.
How does Human Capital Heterogeneity Affect Chinese Enterprises' Direct Investment in Africa?
Authors: Gao Chen , Zhang Dingsheng , Cao Mingshuo , Wen Ya
Published: November 2021

Is human capital heterogeneity a decisive factor for Chinese enterprises to invest in Africa? Based on the Outward Foreign Direct Investment (OFDI） data of Chinese enterprises in 37 African countries from 2007 to 2017, this paper using the FGLS model, is the empirical analysis of the mechanism and effect of the human capital heterogeneity of host countries on OFDI location selection. The human capital heterogeneity can be divided into four dimensions: scale, quality, cost and structure, which can be measured by health level, education level, wage level, child dependency ratio and old-age dependency ratio. The results show that: (1) the host country's human capital scale and child dependency ratio structure have a significant positive impact on decision-making for OFDI; (2) the cost of human capital and the structure of old-age dependency ratio are negatively correlated with the inflow of OFDI; (3) different from the existing conclusions, the quality of human capital will inhibit the inflow of OFDI in the sample period; (4) the extended test shows that the quality of human capital has a significant positive impact on OFDI decision-making. The results of robustness test are reliable. Finally, according to the conclusion of this paper, policy recommendations are put forward.
Perceiving the Role of Communication Skills as a Bridge between the Perception of Spiritual Care and Acceptance of Evidence-Based Nursing Practice—Empirical Model
Authors: Panczyk Mariusz , Iwanow Lucyna , Musik Szymon , Wawrzuta Dominik , Gotlib Joanna , Jaworski Mariusz
Published: November 2021

Decision-making using evidence-based practice (EBP) is generally universally accepted by nurses. Such acceptance may affect the personnel’s behaviour towards patients, which is also demonstrated by taking into consideration the patient’s preferences, including the patient’s spiritual needs, in the care plan. The provision of such care requires the development of an attitude of approval and an adequate level of communicative competence, which will enable the actual implementation of the EBP. The purpose of our study was to assess the perception of spirituality and the nurse’s role in providing spiritual care, as well as the perception of the significance of communication skills in the approval of EBP in professional practice. A multi-centre cross-section study was conducted on a population of 1176 participants (459 undergraduate (Bachelor programme, BP) and 717 postgraduate students (Master programme, MP)) from 10 medical universities in Poland. Three tools were used in the study to evaluate the participants’ approach: Evidence-Based Practice Competence Questionnaire (EBP-COQ), The Spirituality and Spiritual Care Rating Scale (SSCRS), and Communication Skills Attitude Scale (CSAS). Structural equation modelling was used for the analysis. An analysis of structural equations revealed the presence of positive relationships of the attitude to spiritual care and the role of communicative competences with the approach to EBP regardless of the cohort. A significant difference was found related to the influence of age on the attitude toward learning communicative competences. The approval in this respect was observed to decrease with age in the MP group. Increasing approval of EBP requires strengthening the approach to activity-centred spiritual care, with the simultaneous development of a positive attitude towards learning communicative competences. The model reveals the need to integrate a humanistic approach with EBP, which can be achieved by planning different interventions in different groups of recipients: nurses, academic teachers and students.
A Systematic Modelling Procedure to Design Agent-Oriented Control to Coalition of Capabilities - In the Context of I4.0 as Virtual Assets (AAS)
Authors: Veiga Jackson Tavares , Pessoa Marcosiris Amorim de Oliveira , Junqueira Fabrício , Miyagi Paulo Eigi , Dos Santos Filho Diolino José
Published: November 2021

Manufacturing systems need to meet I4.0 guidelines to deal with uncertainty in scenarios of turbulent demand for products. The engineering concepts to define the service’s resources to manufacture the products will be more flexible, ensuring the possibility of re-planning in operation. These can follow the engineering paradigm based on capabilities. The virtualization of industry components and assets achieves the RAMI 4.0 guidelines and (I4.0C), which describes the Asset Administration Shell (AAS). However, AAS are passive components that provide information about I4.0 assets. The proposal of specific paradigms is exposed for managing these components, as is the case of multi-agent systems (MAS) that attribute intelligence to objects. The implementation of resource coalitions with evolutionary architectures (EAS) applies cooperation and capabilities’ association. Therefore, this work focuses on designing a method for modeling the asset administration shell (AAS) as virtual elements orchestrating intelligent agents (MAS) that attribute cooperation and negotiation through contracts to coalitions based on the engineering capabilities concept. The systematic method suggested in this work is partitioned for the composition of objects, AAS elements, and activities that guarantee the relationship between entities. Finally, Production Flow Schema (PFS) refinements are applied to generate the final Petri net models (PN) and validate them with Snoopy simulations. The results achieved demonstrate the validation of the procedure, eliminating interlocking and enabling liveliness to integrate elements behavior.