bluuebunny/crossref_metadata_2025 huggingface dataset:
Penguatan Pendidikan Agama dan Karakter Dasar di Madrasah Diniyah Ali Maksum Yogyakarta
Authors:   Kantor Urusan Agama Kecamatan Pleret, Muzayaroh Ani
Published: April 2022

Pendidikan keagamaan Islam berperan penting dalam membentuk siswa yang berbudi luhur dan berakhlak mulia. Tujuan itu selaras fokus program pemerintah melalui revolusi mental di bidang pendidikan. Penelitian ini berusaha melihat pelaksanaan pendidikan Agama Islam dan pengembangan karakter siswa yang dilakukan oleh Madrasah Diniyah Ali Maksum Krapyak. Penelitian ini menggunakan metode penelitian studi kasus dengan model penelitian evaluasi pendidikan. Hasil yang didapat adalah bahwa pelaksanaan pendidikan agama islam dan pengembangan karakter siswa di Madrasah Diniyah Ali Maksum dilaksanakan sejak tahap persiapan yang mencakup kurikulum, kompetensi guru dan sistem penerimaan siswa baru. Tahap pelaksanaan meliputi metode pembelajaran, pembiasaan dan pengawasan. Sedangkan tahap evaluasi meliputi evaluasi kurikulum, evaluasi kinerja guru dan evaluasi hasil belajar siswa.
Liberasi Kepemimpinan Propetik dalam Satuan Sekolah Dasar dan Menengah Muhammadiyah
Authors:   Universitas Islam Indonesia, Dewantoro M. Hajar , Madjid Abd. ,   Universitas Muhammadiyah Yogyakarta, Wasim Alef Theria ,   UIN Sunan Kalijaga, Hamami Tasman ,   UIN Sunan Kalijaga
Published: April 2022

Tujuan dari penelitian ini adalah untuk mendeskripsikan dan menganalisis transformasi misi pendidikan dasar dan menengah Muhammadiyah dalam kepemimpinan profetik, menjelaskan pengembangan tujuan strategis kecerdasan profetik siswa, dan mendeskripsikan dampak kepemimpinan profetik terhadap organisasi termasuk perubahan yang terjadi pada peserta didik. Penelitian ini menggunakan pendekatan kualitatif dalam perspektif psikologi pendidikan. Metode pengumpulan data yang digunakan yaitu dokumentasi, wawancara, dan observasi langsung. Teknik analisis data penelitian ini mengacu pada teknik eksplikasi, yaitu proses memaparkan dengan jelas pernyataan yang masih bersifat implicit (tersirat) dari responden penelitian. Hasil penelitian ini diperoleh bahwa transformasi misi dalam kepemimpinan profetik diaktualisasikan oleh kepala sekolah yang ditransformasikan dalam manajemen tujuan strategis sekolah di Pendidikan Dasar dan Menengah Muhammadiyah Yogyakarta, konseptualisasi model kepemimpinan profetik yang diterapkan relevan dengan nilai profetik dan terwujud dalam program tujuan strategis profetik untuk mencapai kemajuan sekolah unggulan baik sekolah berasrama ataupun non asrama, aktualisasi kepemimpinan profetik berdampak bagi organisasi sekolah dan kecerdasan profetik peserta didiknya di pendidikan dasar dan menengah Muhammadiyah Yogyakarta berupa prestasi baik dibidang akademik maupun di luar akademik, melaksanakan perintah agama, berakhlak mulia, menjunjung tinggi almamater, terlepas dari sifat-sifat remaja, separti tawuran dan sifat-sifat yang dilarang agama, memiliki jiwa usaha dan kepemimpinan, jujur dan bermental mandiri. Untuk penelitian selanjutnya, sistem pendidikan berbasis profetik harus diterapkan secara holistic dengan pendekatan yang komplit sehingga dapat mencapai visi akhlak al-karimah.
A Raiz das Coisas: Rui Barbosa e o Brasil no mundo
Authors: Lessa Antônio Carlos
Published: April 2022

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Mercosul
Authors: Lessa Antônio Carlos , Arraes Virgílio Caixeta
Published: April 2022

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FTAA and the Brazilian private sector: two exemplary cases
Authors: Lessa Antônio Carlos
Published: April 2022

This article seeks to analyze the growing Brazilian private sector, its global performance and outline the effects that it will suffer from the implementation of the FTAA.
The Elysée Treaty and its lessons for Mercosur
Authors: Lessa Antônio Carlos
Published: April 2022

Taking the Elysée treaty, signed between France and Germany in 1963, this article seeks to analyze the possibilities and the need to expand the possibilities of student exchanges between Mercosur member countries.
Trinta anos de Ensino de Relações Internacionais em nível de graduação no Brasil
Authors: Lessa Antônio Carlos
Published: April 2022

O presente artigo busca analisar o campo de estudos de Relações Internacionais e realizar um breve balanço de seus trinta anos desde a criação do primeiro curso de bacharelado no Brasil.
Os problemas recentes e as muitas virtudes do Mercado de trabalho para profissionais de Relações Internacionais no Brasil
Authors: Lessa Antônio Carlos
Published: April 2022

Dada grande expansão recente dos cursos de Relações Internacionais no Brasil, a  presente análise tem como foco expor as distintas possibilidades de atuação do profissional de Relações Internacionais no mercado de trabalho.
The recent evolution of studies and postgraduate programs in International Relations in Brazil
Authors: Lessa Antônio Carlos
Published: April 2022

This article deals with the evolution of academic activity in International Relations in Brazil and the development of this field of study in academia.
A Batalha pela Espanha: a guerra civil espanhola (1936-1939)
Authors: Lessa Antônio Carlos
Published: April 2022

Resenha de "A Batalha pela Espanha: a guerra civil espanhola (1936-1939)"
The Fifth Republic in 2008: what is celebrated within the framework of the French Constitution of 1958
Authors: Lessa Antônio Carlos
Published: April 2022

With the preservation of democratic institutions, which French political life did not know in the decades that preceded the regime of the Fifth Republic.
Mechanically Enhanced Hydrophobic Metal Surfaces Enabled by 3D Gradient Structures
Authors: Zhang Xiaohan , Liu Jian , Xia Min , Hu Yaowu
Published: April 2022

The mechanical properties and stability of hydrophobic surface structures prepared by traditional methods are still the main technical bottlenecks restricting the broad application of hydrophobic systems on workpiece surfaces. In this contribution, we propose a technique called selective laser shock peening (SLSP) to enable large-scale high efficient, low-cost manufacturing of hydrophobic metal surfaces with enhanced mechanical properties for durable applications. Using the method of experimental investigation combined with numerical calculation, the hydrophobic properties, mechanical properties, and tribological properties of the samples prepared under SLSP, all-laser shock peening (ALSP), and non-laser shock peening (NLSP) are studied. The SLSP process could prepare a 3D gradient structure material with surface structures, a two-phase (strong phase, soft phase) distribution on the surface, and a multi-level gradient distribution in the thickness direction. Compared with the 2D gradient structure prepared by the traditional process, 3D gradient structures by SLSP have more significant advantages in improving the wetting behavior and the mechanical properties of the material, which proves SLSP to be a novel method to fabricate functional metal surface structures, with highly high engineering application value.
LAS ESPECTACULARES GEODAS DE GOETHITA TABULAR DE TORDELRÁBANO (PROVINCIA DE GUADALAJARA): ESTUDIO ESTRATIGRÁFICO Y PETROGRÁFICO
Authors: Martínez León Jorge
Published: April 2022

Las espectaculares geodas de goethita tabular de la localidad de Tordelrábano (Provincia de Guadalajara) son de origen edáfico y se localizan en la parte alta de las facies Buntsandstein. Se tratan de unas geodas constituidas por unas envueltas carbonáticas y silíceas, en cuyo interior aparecen minerales férricos como el hematites y la goethita creciendo en forma tabular, inusual en este tipo de mineralizaciones. En este trabajo se ha realizado un estudio estratigráfico, para entender la formación de las geodas a partir de un encuadre geológico único y un estudio petrográfico para establecer un orden diagenético en la formación de estas. Para el estudio estratigráfico se ha levantado una columna estratigráfica en el afloramiento donde se encuadran las geodas. Se ha llevado a cabo un análisis microscópico a partir de una muestra recogida en campo a la que se le ha realizado una lámina delgada. Aplicándola técnicas de catodoluminiscencia con el fin de establecer un orden diagenético de la formación de los minerales constituyentes de las geodas.
GEOTECNIA DE UNIDADES SALINAS
Authors: Lombardero Barceló Manuel , Llana Fernández Marcos
Published: April 2022

Debido al largo proceso administrativo que habitualmente sigue en España el proyecto y construcción de las grandes obras públicas, ha ocurrido algunas veces que, una vez establecido un trazado o un emplazamiento, resulta extremadamente difícil y costoso cambiarlo sustancialmente, incluso aunque los estudios posteriores demuestren la existencia de una geología problemática. En algunas ocasiones, los aspectos geológicos no han tenido la suficiente profundidad en las primeras etapas de proyecto (anteproyecto, estudio de factibilidad, estudio informativo): podrían citarse ejemplos de obras en las que el presupuesto inicial se ha triplicado por problemas geológicos no detectados en las primeras fases de estudio. En este trabajo, pretendemos dar a conocer un ejemplo de lo contrario, como (y gracias a una serie de dilaciones en proceso administrativo), ha sido posible variar sustancialmente el trazado de una línea ferroviaria en fase temprana de proyecto, evitando un terreno salino muy desfavorable.
La gran terapeuta
Authors: Nervi Vidal Mario A.
Published: April 2022

This paper is a commentary on Professor Sandra Buechler's paper “Sources of Inspiration for Clinicians”, presented at the Institute for Relational Psychotherapy in 2022, and included in this dossier.
La expresión artística como una herramienta terapéutica: El artista y el paciente
Authors: Rabi Cynthia
Published: April 2022

This paper is an attempt to resolve some theoretical concerns that arise in therapeutic work where art therapy techniques have been applied to the patients, citing some great thinkers of the relational model and its predecessors, as well as philosophers who theorize about the artistic creation. The text begins with the analysis of an interview with an artist, a speech that serves as a common thread woven with ideas capture the emotional background of the artistic experience and how it is transformed into a tool for therapeutic purposes. Almost at the end of the text a brief analysis is carried out regarding the visual artistic techniques applied to 2 patients of the author of this paper.
En-claves relacionales presentes en Recuerdo, repetición y elaboración (Freud, 1914) – Primera Parte: La encrucijada freudiana
Authors:   Instituto de Psicoterapia Relacional, Tinajas Puertas Antonio A.
Published: April 2022

Subjected to the historical-critical method, and resorting to the content analysis technique, this work takes as a reference the Freudian technical study known as Remembrance, Repetition and Elaboration (Freud, 1914) to substantiate that certain concepts, precepts, or therapeutic lines of action – that is, theoretical-technical ideas- ascribed to the so-called psycho-relational analysis, are already present in the programmatic Freudian study written in 1914.
Análisis narrativo de escenas de travestismo y su procesamiento en psicoterapia: posiciones psíquicas del relator,
Authors:   ITESO, Sánchez Antillón Antonio , Roque Tovar Bernardo Enrique , Casillas Arista Eugenia Catalina , Zohn Muldoon Tania Carina
Published: April 2022

The objective of this article is to analyze transvestism scenes and the concomitant thought processes of a psychotherapy consultant, to show if there are changes in the psychic position of the subject. The analysis method is based on narratology and the semiotics of the text. The results show four figures in which the narratological and semantic dilemmas are specified: sexual awakening, the difference between the sexes, denying or affirming life and the conjunction between the sexes. The narrative of possible improvement is specified in the narrator's distance from the actant mother's gaze and in the scene of supposition where he glimpses in the future forming a family. The scenes and the position of the narrator are interpreted from the construction of the semiotic subject. The results are discussed with the help of concepts in psychoanalysis, such as: constitution of the self, identifications, incest, and the role of the phallus in sexual difference. Some of these concepts are articulated with other authors. It discourses on the lability of the self and the other, as well as between the masculine-feminine, the relationship between compulsive acts of cross-dressing and the absence of incestuous prohibition. It is concluded that there is a change in the narrative and the psychic position of the narrator. And that the subjective dilemmas of the analyzed case is the expression of the current social dilemma where the diffusion of identity is at stake.
Identification of Safe Channels for Screws in the Anterior Pelvic Ring Fixation System
Authors: Liu Lin , Fan Shicai , Zeng Donggui , Song Hui , Zeng Letian , Wen Xiangyuan , Jin Dadi
Published: April 2022

Background: There have been few studies on insertion of fixation screws for the anterior pelvic ring system. Objective: To identify safe channels for fixation screws in the anterior pelvic fixation system. |Methods: Screw insertion was simulated into a total of 40 pelvic finite element models as well as 16 fresh pelvic specimens and the channel parameters were measured. Results: Finite elements (male, female): screws in ilium: length 114.4 ± 4.1 and 107.6 ± 8.3 mm, respectively; diameter 11.7 ± 0.5 and 10.0 ± 0.6 mm, distance between screw and anterior inferior iliac spine: 5.5 ± 1.0 and 5.6 ± 1.0 mm, angle of coronal plane 55.8 ± 2.4 degrees and 50.6 ± 3.1 degrees, angle of sagittal plane 26.6 ± 1.0 degrees and 24.5 ± 1.9 degrees and angle of horizontal plane 64.9 ± 3.7 and 58.1 ± 3.1. Screws in pubis: length 47.0 ± 2.0 and 39.8 ± 3.9 mm, diameter 7.1 ± 0.4 and 6.1 ± 0.4 mm. Specimens (male, female): distance between screw and anterior inferior iliac spine: 5.5 ± 0.5 and 5.6 ± 0.7 mm, angle of coronal plane 55.9 ± 1.3 degrees and 50.7 ± 1.5 degrees, angle of sagittal plane 26.7 ± 0.5 degrees and 24.1 ± 0.9 degrees and angle of horizontal plane 64.8 ± 0.6 degrees and 58.8 ± 0.8 degrees. Comparison between female and male in each group: differences in distances between screws and anterior inferior iliac spine and median line of symphysis pubis (P > 0.05) were not statistically significant; differences in the remaining parameters were statistically significant (P < 0.05). Conclusions: If surgeons payed attention to sex differences, select screws of appropriate diameter and length, and hold the insertion position and direction, screws in the anterior pelvic ring fixation system could be safely inserted.
Dynamic NLR and PLR in predicting Covid-19 severity: a retrospective cohort study
Authors: Asperges Erika , Albi Giuseppe , Zuccaro Valentina , Sambo Margherita , Pieri Teresa Chiara , Calia Matteo , Colaneri Marta , Maiocchi Laura , Melazzini Federica , Lasagna Angioletta , Peri Andrea , Mojoli Francesco , Sacchi Paolo , Bruno Raffaele
Published: April 2022

Background: the hyperinflammation phase of severe SARS-CoV-2 is characterized by complete blood count alterations. In this context, the neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR) can be used as prognostic factors. We study NLR and PLR trends at different timepoints and compute optimal cutoffs to predict four outcomes: use of Continuous Positive Airways Pressure (CPAP), ICU admission, invasive ventilation and death. Methods: we retrospectively included all adult patients with SARS-CoV-2 pneumonia admitted from 23rd January 2020 to 18th May 2021. Data were extracted using ICD9 codes and our Covid-19 registry. Analyses included descriptive statistics and non parametric tests to study the ability of NLR and PLR to distinguish the patients’ outcomes at each timepoint. ROC curves were built for NLR and PLR at each timepoint (minus discharge) in order to identify cutoffs to distinguish severe and non severe disease and their statistical significance was assessed with the Chi-square test. NLR and PLR were compared with DeLong’s test. Results: we included 2169 patients. NLR and PLR were higher in severe Covid-19 at all the timepoints, with a difference that gets bigger and a trend that is steeper in more severe disease. Both ratios were able to distinguish the outcomes at each timepoint. For NLR, the areas under the curve (AUROC) ranged between 0.59 and 0.81, for PLR, between 0.53 and 0.67. From each ROC curve we computed an optimal cutoff value (e.g. NLR 7 for CPAP for males at admission). NLR performed better than PLR. Conclusion: our results are in line with other studies that computed NLR and PLR trends and values in disease, especially with those that distinguished between different grades of severity. Our study is retrospective and single centre, and is limited by selection bias, but includes more than 2000 patients, thus limiting the confounding factors and outliers. Our cutoffs do not only deal with severity and mortality but allow for a more tailored approach. Future prospect include validating our cutoffs in a prospective cohort and comparing their performance against other Covid19 scores.
Symptoms of Anxiety but not Depression Before Start of Taxane-Based Chemotherapy are Associated with Peripheral Neuropathy: a Multicenter Study in Women with Breast Cancer
Authors: Hinnen Chris , Verhoeff-Jahja R. , Kuile M.M. ter , Weijl N.I. , Oosterkamp H.M. , Cloos M. , Portielje J.E.A. , Kroep J.R.
Published: April 2022

Background Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of chemotherapy, especially after taxane based therapy. This study aimed to examine the relationship between symptoms of anxiety and depression before start of taxane-based chemotherapy and the development of CIPN in women with breast cancer.Methods In this prospective study, women with breast cancer receiving taxane-based (neo)adjuvant chemotherapy were recruited from four hospitals in the Netherlands. Patients completed questionnaires assessing anxiety and depressive symptoms before treatment and CIPN before treatment (T0), 6 weeks after start of treatment (T1), after the last cycle of chemotherapy (T2) and 6 months after end of treatment (T3). Mixed model analyses were used to investigate whether medium/high levels of anxiety or depression at baseline are associated with the level of CIPN during and after treatment. Results Among the 61 participating women, 14 (23%) reported medium/high levels of anxiety and 29 (47.5%) reported medium/high levels of depressive symptoms at baseline. The group of women with medium/high baseline levels of anxiety showed a significantly higher increase in CIPN during and after chemotherapy than women with low baseline levels of anxiety (p < .001). No relationship between depressive symptoms at baseline and the development of CIPN was found.Conclusion This study showed that baseline medium to high levels of anxiety, but not depressive symptoms impacted the development of CIPN during and in the 6 months after treatment.
RIS-Assisted Multi-User MIMO-DQSM Transmission System
Authors: Castillo-Soria Francisco R. , Azurdia-Meza Cesar A. , Kumaravelu Vinoth Babu , Simón Jorge , Gutierrez Carlos , Del-Puerto-Flores J. A.
Published: April 2022

This paper presents a reconfigurable intelligent surface (RIS) assisted multiuser (MU) multiple-input multiple-output (MIMO) system. Instead of being applied at the remote RIS, the phase shift vector is applied at the base station (BS) by using an additional precoding stage. The overall system performance is improved by incorporating a double quadrature spatial modulation (DQSM) transmission technique. Results show that the proposed system has gains of up to 17 dB in bit error rate (BER) and a reduction in detection complexity of 51% when compared with the conventional MU-MIMO system based on spatial multiplexing (SMux). Compared with a similar system based on amplify and forward (AF) relay-assisted technique, the proposed system has up to 18 dB gain in BER performance under the same conditions and parameters. Mainly, the proposed system significantly reduces the signal processing required at the RIS.
A Landslide Susceptibility Mapping Using CIBD-CURE Algorithm and LEPAM Methods for Baota District, China
Authors: Mwakapesa Deborah S. , Xiaoji Lan , Mensah I. K. , Nanehkaran Y. A. , Xiangtai Wang , Li Ye , Liang Chen , Wei Liu , Mao Yimin
Published: April 2022

Landslide susceptibility mapping (LSM) is one of the crucial steps in managing and mitigating landslides. This study targets at developing a new LSM model for Baota District in China, using a new clustering method namely CIBD-CURE, which combines the city block distance (CIBD) and traditional clustering using representatives (CURE) algorithm. It aims at addressing limitations of inability to identify clusters (subclasses) with arbitrary shapes and varying sizes, sensitivity to noise, inability to perform well in large study areas with large dataset and inability to process rainfall (uncertain) data, which affect the results of traditional clustering algorithms in LSM. The CIBD was introduced into the CURE algorithm for processing uncertain data, then CIBD-CURE partitioned the mapping units into arbitrary shaped and sized subclasses with respect to their underlying geology and topography characteristics, and handled noise successfully. Furthermore, LEPAM method was proposed to sort the subclasses into five landslide susceptibility levels. Finally, standard statistical measures were applied to evaluate the model’s performance and compared it against CURE, AHC-OLID, HC and KPSO clustering models, along with DTU and NBU classification models. The result analysis showed data the proposed model attained higher performance. This LSM study will be useful for landslides management strategies not only for this study area but also other affected areas around the world.
Pulmonary and Renal Long COVID at Two-year Revisit
Authors: Guo Tiannan , Wang Jing , Liang Xiao , Zheng Yufen , Zhu Yi , Zhou Kai , Wu Xiaomai , Sun Rui , Hu Yifan , Zhu Xiaoli , Chi Hongbo , Chen Shanjun , Lyu Mengge , Xie Yuting , Yi Xiao , Liu Wei , Cai Xue , Li Sainan , Zhang Qiushi , Wu Chunlong , Shi Yingqiu , Wang Donglian , Peng Minfei , Zhang Ying , Liu Huafen , Zhang Chao , Quan Sheng , Kong Ziqing , Kang Zhouyang , Zhu Guangjun , Zhu Hongguo , Chen Shiyong , Liang Junbo , Yang Hai , Pang Jianxin , Fang Yicheng , Chen Haixiao , Li Jun , Xu Jiaqin , Shen Bo
Published: April 2022

More than 450 million individuals have recovered from COVID-19, but little is known about the host responses to long COVID. We performed proteomic and metabolomic analyses of 991 blood and urine specimens from 144 COVID-19 patients with comprehensive clinical data and up to 763 days of follow up. Our data showed that the lungs and kidneys are the most vulnerable organs in long COVID patients. Pulmonary and renal long COVID of one-year revisit can be predicted by a machine learning model based on clinical and multi-omics data collected during the first month from the disease onset with an ACC of 87.5%. Serum protein SFTPB and ATR were associated with pulmonary long COVID and might be potential therapeutic targets. Notably, our data show that all the patients with persistent pulmonary ground glass opacity or patchy opacity lesions developed into pulmonary fibrosis at two-year revisit. Together, this study depicts the longitudinal clinical and molecular landscape of COVID-19 with up to two-year follow-up and presents a method to predict pulmonary and renal long COVID.
Long-term effectiveness of XEN 45 gel-stent in open-angle glaucoma patients
Authors: Marcos-Parra María Teresa , Salinas-López Javier Alejandro , Mateos-Marcos Carlos , Moreno-Castro Lucia , Moreira Angi Lizbeth Mendoza , Santonja Juan José Pérez
Published: April 2022

Purpose: To assess the effectiveness of XEN45, either alone or in combination with phacoemulsification, in open-angle glaucoma (OAG) patients in a real-world scenario. Additionally, we evaluated the effect of the surgeon's experience on clinical outcomes. Methods: Retrospective and single center study conducted on OAG patients who underwent XEN45-implant, either alone or in combination with cataract surgery. We compared the clinical outcomes of the first-30 XEN devices implanted from June-2016 (First-cohort) versus the first-30 XEN devices implanted from January-2018 (second-cohort). The primary endpoint was the mean change in intraocular pressure (IOP) from baseline to the last follow-up visit. Results: One Hundred-and-fifty-four eyes, 37 (24.0%) eyes who underwent XEN-alone and 117 (76.0%) eyes who underwent XEN+Phacoemulsification were included. The mean preoperative IOP was significantly lowered from 19.1±5.0 mmHg to 14.9±3.8 mmHg at month-36, p<0.0001. Preoperative IOP was significantly lowered from 19.2±5.3 mmHg and 18.9±4.7 mmHg to 15.2±4.0 mm Hg and 14.1±3.1 mmHg at month-24 in the first- and second-cohorts, respectively; p<0.0001 each, with no significant differences between them. In the overall study population, the mean number of antiglaucoma medications was significantly reduced from 2.1±0.8 to 0.2±0.6, p<0.0001. The proportion of eyes with a final IOP ≤14 mmHg and ≤16 mmHg, without treatment, was significantly greater in the second cohort (p=0.0471 and 0.0047, respectively). Thirty-six (23.4%) eyes required a needling procedure. Conclusions: XEN implant, significantly lowered IOP and reduced the need of ocular hypotensive medication, while maintaining a good safety profile. Additionally, XEN45 was associated with a short learning curve.
Infrared small target detection based on multi-directional cumulative measure
Authors: Zhang Guofeng , Ma Hongbing , Hamdulla Askar , Ubul kurban
Published: April 2022

Robustness of small target detection is a researchable hotspot in infrared surveillance system. The residual phenomenon of background clutter is universal in current local comparison methods. Algorithm of sparse low-rank decomposition restoration cannot be applied to the actual situations due to the long time consumption.This letter proposes a multi-directional cumulative measure(MDCM) to enhance saliency and effectiveness of weak-small target detection. Firstly, multi-directional cumulative mean difference is implemented in central layer and background layer to estimate the background, while the multi-directional cumulative derivative multiplying is calculated in central-active layer to characterize overall target’ heterogeneity, then technology of image fusion is adopted to eliminate interference of false target. Finally, a simple adjudicative technology is employed toward separated target region from complex scenes. Compared to up to date existing approaches,extensive simulational testing on four public datasets prove that proposed approach is capable of separating small targets efficiently from an irregular background in a single-scale window and achieve a comparable or even better accuracy.
Pro-survival factor EDEM3 confers therapy resistance in prostate cancer
Authors: Scott Emma , Garnham Rebecca , Cheung Kathleen , Duxfield Adam , Elliott David , Munkley Jennifer
Published: April 2022

Prostate cancer is the most common cancer in men, and it is primarily driven by androgen steroid hormones. The glycosylation enzyme EDEM3 is controlled by androgen signalling and important for prostate cancer viability. EDEM3 is a mannosidase that trims mannose from mis-folded glycoproteins, tagging them for degradation through endoplasmic reticulum associated degradation. Here, we find that EDEM3 is upregulated in prostate cancer, and this is linked to poorer disease-free survival. Depletion of EDEM3 from prostate cancer cells induces an ER stress transcriptomic signature, and EDEM3 overexpression is cyto-protective against ER stressors. EDEM3 expression also positively correlates with genes involved in the unfolded protein response in prostate cancer patients and its expression can be induced through exposure to radiation. Importantly, the overexpression of EDEM3 promotes radio-resistance in prostate cancer cells and radio-resistance can be reduced through depletion of EDEM3. Our data thus implicate increased levels of EDEM3 with a role in prostate cancer pathology and reveal a new therapeutic opportunity to sensitise prostate tumours to radiotherapy.
Making Better Keratoplasty Decisions for Acanthamoeba Keratitis: A Meta-analysis
Authors: Wang Leying , Wei Zhenyu , Cao Kai , Xu Xizhan , Zhang Zijun , Chen Qiankun , Liang Qingfeng
Published: April 2022

Acanthamoeba keratitis (AK) is a blinding disease with increasing incidence. Keratoplasty is the common therapy method for AK; however, the suitable times and types of keratoplasty for AK remains unclear. These systemic review intended to assess the outcomes of AK undergoing different keratoplasty procedures. Literature searches were conducted in Pubmed, EMBASE, Web of Science, and the Cochrane. Eleven studies with 216 eyes were included. The meta-analysis showed optical keratoplasty had better best corrected visual acuity (BCVA), higher graft survival rate, lower recurrence and multiple keratoplasties rate than therapeutic keratoplasty. The occurrence rate of postoperative complications were similar between optical keratoplasty and therapeutic keratoplasty. The AK patients performed therapeutic keratoplasty within 5 months of AK onset had significant better final BCVA than those who after 5 months of AK duration. Moreover, therapeutic deep anterior lamellar keratoplasty (TDALK) reserved better BCVA than therapeutic penetrating keratoplasty (TPK). The eyes performed TPK were prone to need multiple keratoplasties than those with TDALK. These results suggested optical keratoplasty was superior to therapeutic keratoplasty in AK patients. The drug-resistant AK patients should be underwent therapeutic keratoplasty promptly, especially within 5 months of AK onset. TDALK was a preferable therapeutic keratoplasty option for AK patients where possible.
Bernoulli wavelet least square support vector regression: Robust numerical method for systems of fractional differential equations
Authors: Rahimkhani Parisa , Ordokhani Yadollah , Sabermahani Sedigheh
Published: April 2022

In this study, a new hybrid method is developed to solve a system of linear or nonlinear fractional differential equations using Bernoulli wavelets (Bws) and the least square support vector regression(LS-SVR). For this purpose, we present Bw operator of Riemann-Liouville fractional integration for Bw and use it in our scheme. In the proposed technique, we approximate the unknown functions via Bws, then with the help of Bw operator of fractional integration and LS-SVR, we reduce the problem to an algebraic system. In this way, we simplify the computation of the considered system. The error analysis is proposed. Finally, we demonstrate the applicability of the present scheme by solving several numerical examples.
Richness contributes higher on soil microbial community resistance while nutrient contributes higher on resilience to a thermal stress
Authors: Zhou Hanchang , Ma Anzhou , Chang Ruiying , Liu Guohua , Zhuang Guoqiang
Published: April 2022

Soil microbial communities play irreplaceable roles in regulating environment. However, global climate change induced extreme weather events were reported capable reshape microbial community composition, which exert possible influences on the environment regulation function. Unfortunately, the compositional response of microbial community to extreme weather events and the potential factors regulating this response were still scarcely explored up to date. To fill the gap, here we sampled soils from 5 different type ecosystems and conducted a simulated extreme high-temperature stress experiment. The results showed that the complex ecosystems (like forests) had higher richness reduction than simple ecosystems (like bare land) during stress stage, most bacterial community richness kept decreasing while most fungal community richness were relatively unchanged during recovery stage. Despite the fungal communities in different types of ecosystems showed different and specific changes in the face of stress during the stress and recovery stage, the relative abundances of α-Proteobacteria were enhanced by stress in simple ecosystems but decreased in complex ecosystems, and the recovery stage of simple ecosystems were characterized by the trade-off between α-, β- and γ-Proteobacteria while complex ecosystems were by Firmicutes. Further analysis showed that the simple ecosystems tend to possess higher resistance and lower resilience while the complex ecosystems displayed the opposite trend. Resistance and resilience were significantly negatively correlated. Structural equation modeling showed that richness provided a higher contribution to bacterial and fungal resistance than to resilience while nutrients provided a higher contribution to resilience than to resistance. This research explored the influence of extreme high temperature stress on soil microbial community and the resistance and resilience of microbial community different types ecosystems to the stress, highlighted the respectively greater relative contribution of richness and nutrients offered to resistance and resilience, which provided valuable information for future prediction on microbial community response to climatic stresses.
L.reuteri JMR-01 adjuvant 12C6+ irradiation exert anti-colon carcinoma effects by modulating the gut microbiota in mice
Authors: Bai Jin , Wang Shuyang , Xu Fuqiang , Dong Miaoyin , Wang Junkai , Sun Xisi , Xiao Guoqing
Published: April 2022

Probiotics such as Lactobacillus can modulate the intestinal microbiota and have been considered as an effective strategy for ameliorating colon carcinoma; nevertheless, its efficiency remains the biggest challenge. We investigated the efficacy of JMR-01 adjuvant 12C6+ irradiation on the treatment of mice bearing CT-26 and clarified the underlying mechanisms including modulating immune cells and intestinal flora. Anti-proliferation effect of live probiotic JMR-01 and inactived probiotic (LP + IP) on CT-26 reached a maximum of 39.55% among other experiment groups at 24 h when the ratio of cell to CFU was 1:1 in vitro, which was at a high level to our knowledge. These activities have been fully validated in vivo, mice treated by 12C6+ irradiation + LP + IP (IR + LP + IP) for fifty-day held the highest survival rate (71.4%) and the cure rate (14.3%), which were higher than that in the reported literatures. Additionally, we found that the strongest stimulation index of splenocyte (2.47) and the phagocytosis index peritoneal macrophage (3.68) were achieved by LP + IP compared with single LP and IP. We demonstrated a significantly decreased abundance of Bacteroides fragilis, Clostridium perfringens and the increased abundance of Lactobacillus and Bifidobacterium in mice administrated of LP + IP via plate counting of microbial in fecal. Moreover, fecal enzyme activities were dramatically decreasing and short chain fatty acids (SCFA) concentrations were significantly increasing in IR + LP + IP group compared with tumor control group, which was consistent with the trend of plate counting results. JMR-01 LP + IP adjuvant 12C6+ irradiation could mitigate cancer progression by modulating immune cells and intestinal flora.
Distribution of transient receptor potential vanilloid types 2 and 1 in the distal colon in a trinitrobenzene sulfonicacid-induced rat colitis model with visceral hypersensitivity
Authors: Matsumoto Kenjiro , Sugimoto Fumika , Mizuno Toshiki , Hayashi Taisei , Okamura Ririka , Nishioka Takuya , Yasuda Hiroyuki , Horie Syunji , Kido Mizuho A. , Kato Shinichi
Published: April 2022

Transient receptor potential vanilloid type 2 (TRPV2) and type 1 (TRPV1) are originally identified as heat-sensitive TRP channels. We compared the expression patterns of TRPV2 and TRPV1 in the rat distal colon and extrinsic primary afferent neurons, and investigated their roles in visceral hypersensitivity in 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis rats. Both TRPV2 and TRPV1 expressions in the colon, dorsal root ganglion (DRG), and nodose ganglion (NG) were significantly upregulated in the TNBS-induced colitis model. TRPV2 cell bodies co-localized with the intrinsic primary afferent marker NeuN and the inhibitory motor neuronal marker nNOS in the myenteric plexus. TRPV2 expressions were further detected in the resident macrophage marker ED2 in the mucosa. In contrast, no TRPV1-expressing cell bodies were detected in the myenteric plexus. Both TRPV2- and TRPV1-positive cell bodies in the DRG and NG were double-labeled with the neuronal retrograde tracer fluorescent fluorogold. Large- and medium-sized TRPV2-positive neurons were labeled with the A-fiber marker NF200, calcitonin gene-related peptide (CGRP), and substance P (SP) in the DRG while small-sized TRPV1-positive neurons were labeled with the C-fiber markers IB4, CGRP, and substance P. TRPV2-and TRPV1-positive NG neurons were labeled with NF200 and IB4. Although TNBS treatment did not affect the TRPV1 and TRPV2 subpopulations in the DRG and NG, increased p-ERK1/2-positiveneurons, which co-localized with TRPV1, and TRPV2. Both TRPV2 and TRPV1 antagonists significantly alleviated visceral hypersensitivity in TNBS-induced colitis model rats. These findings suggest that sensitization and upregulation of intrinsic/extrinsic TRPV2- and extrinsic TRPV1-neurons may contribute to visceral hypersensitivity.
Spouses as trained ICU doulas have significant effects on the psychological outcomes of intensive care survivors: A retrospective secondary analysis
Authors: Samim Abbas , Rahimi-Bashar Farshid , Gohari-Moghadam Keivan , Izadi Morteza , Karimi Leila , Jarineshin Hashem , Ghamari Ali Akbar , Amini Hossein , Barasteh Salman , Jafari-Iraqi Iman , Vahedian-Azimi Amir
Published: April 2022

The purpose of this study was to investigate the effect of psychological support provided by the patient's spouse as trained ICU doulas on mental disorders after 12 months of hospital discharge. This retrospective secondary analysis was conducted on married patients (patient- and patient's spouse as a unit) with no history of mental disorders. In this study, three groups of patients were compared with each other; ICU survivors with trained spouse as ICU-doulas (n = 359, 29%), ICU survivors without trained spouse (n = 461, 37.3%) and discharged patients from general wards without trained spouse (n = 416, 33.7%). In multivariate binary logistic regression, the odds ratio (OR) of mental disorders based on WHO-5 index (OR: 0.344, 95% CI: 0.265–0.446, P < 0.001), HADS-depression score (OR: 0.762, 95% CI: 0.593–0.979, P = 0.033), HADS-anxiety score (OR: 0.372, 95% CI: 0.287–0.481, P < 0.001) and IES-R score (OR: OR: 0.367, 95%CI: 0.184–0.875, P < 0.001), were significantly decreased in the ICU survivor with trained spouse as ICU-doulas compared with the ICU survivors without doulas. However, there was no statistically significant difference was found between ICU survivors without doulas and no ICU patients without doulas. Our data suggest that the patient's spouse as trained ICU doulas could feasibly and successfully provide psychological support in the ICU setting. Since psychologist support by patient's spouse is not associated with any adverse effects, implementing this service should be considered.
An assessment of strategies for sustainability priority challenges in Jordan using a Water-Energy-Food Nexus approach
Authors: Ramirez Camilo , Almulla Youssef , Joyce Brian , Huber-Lee Annette , Nerini Francesco Fuso
Published: April 2022

This study aimed at supporting robust decision-making for planning and management of water-energy-food Nexus systems in the country of Jordan. Nexus priority challenges in Jordan were identified as 1) water scarcity, 2) agricultural productivity & water quality, and 3) shift to energy independence. We created a water-energy-food Nexus model that integrates three modelling frameworks: 1) the Water Evaluation and Planning system WEAP model to estimate water demands, supplies and allocation; 2) the MABIA model to estimate crop production, and, 3) a GIS-based energy modelling tool to estimate energy requirements of the water system. Through a set of scenario runs, results show how desalination is needed to address water scarcity, but it has to be coupled with low-carbon electricity generation in order to not exacerbate climate change. Improving water productivity in agriculture improves most of the studied dimensions across the water-energy-food security nexus; however, it does little for water scarcity at the municipal level. Reducing non-revenue water can have positive effects on municipal unmet demand and reduction of energy for pumping, but it does not improve agricultural water productivity and may have negative feedback effects on the Jordan Valleys aquifer levels. Energy efficiency can support energy intensive projects as desalination by substantially reducing the load on the energy system, preventing increased emissions and achieving a more resilient water system. Finally, when all interventions are considered together all of the major drawbacks are reduced and the benefits augmented, producing a more holistic solution to the WEF Nexus challenges in Jordan.
Prognostics of systemic malignancy ICD-O topography and morphology types on brain metastases: an NCDB time-to-event cohort
Authors: Alexopoulos Georgios , Zhang Justin , Karampelas Ioannis , Patel Mayur , Mercier Philippe
Published: April 2022

Background: The primary site and histology of systemic malignancy are known predictors of progression to brain metastases(BM). We investigated the combinational interactions of ICD-O primary topography and morphology types on the survival of BM after adjusting for relevant clinical and demographic prognostic factors. Methods: The cohort included all adult patients with BM at diagnosis of an invasive malignancy in the National Cancer Database(2010-2018). The sample consisted of 180,150 entries out of 14,279,749 cancer patients screened. A survival analysis of the topography- and histology- specific time to death was performed. Multivariate Cox regression revealed violations of the proportional hazard assumption for multiple covariates. Parametric models using a log-logistic distribution best described the population survival pattern. Results: The primary topography “prostate” and morphology “choriocarcinoma” provided the strongest survival benefit among ICD-O types, while BM from prostate demonstrated a 14-month median overall increase in survival probability. Favorable prognostics were BM from breast, bone/joints, and testis; also, the morphologies of carcinoid tumor, mature B-cell lymphoma, and papillary adenocarcinoma. Poor prognostics were BM from gastrointestinal(liver, biliary tree, pancreas, gallbladder) and gynecologic malignancies. All morphologies of spindle cell carcinoma, hemangiosarcoma, undifferentiated carcinoma, Ewing sarcoma, pseudosarcomatous carcinoma, renal cell carcinoma/sarcomatoid, signet ring cell carcinoma, spindle cell sarcoma, and squamous cell carcinoma/spindle cell were associated with poor survival. Conclusions: This is the largest cohort providing an unbiased estimate of the adjusted ICD-O topography and morphology effect sizes. The results can be summarized as a booklet for prognostic classification of disease in patients with BM secondary to systemic malignancy.
Förderung der emotionalen und sozialen Kompetenzen mit XR-Medienkunstprojekten
Authors: Zembala Anna
Published: April 2022

Das gegenwärtig starke Interesse an Augmented Reality (AR) und Virtual Reality (VR) bzw. Extended Reality (XR) auch Mixed Reality (MR) genannt – einer Mischform der AR- und VR-Umgebung – stellt eine Chance dar, sich mit den aktuellen didaktischen und pädagogischen Herausforderungen des schulischen und ausserschulischen Lernens auseinanderzusetzen. Während die kognitiven Kompetenzen in Lernprozessen in multimedialer XR-Umgebung oft berücksichtigt werden, werden die emotionalen und sozialen Kompetenzen selten bedacht. Sowohl die gegenwärtigen Medienkunstprojekte als auch positive (SEL) und transformative Lerntheorien (Illeris) können neue Impulse für XR-Bildungsprojekte geben, die eben emotionale und soziale Kompetenzen einbeziehen und fördern. Nicht die Technologie oder die Endgeräte sollten über die Qualität der XR-Bildungsprojekte entscheiden, sondern die Inhalte, mit denen sie sich insbesondere gut fördern lassen, eine positive Lernatmosphäre, zu der sie beitragen und die Persönlichkeitsförderung, die sie unterstützen können.
CURRENT DEVELOPEMENTS ABOUT LIFEPO4 BATTERY FOR STATIONARY ENERGY STORAGE IN AFRICA
Authors:   Laboratoire dEnergetique et de Mecanique Appliquee (LEMA,), Ecole Polytechnique dAbomey-Calavi, Ecole Doctorale des Sciences de lIngenieur, Universite dAbomey-Calavi, BENIN., Prodjinonto Vincent , M. Godonou Oscar ,   Laboratoire dEnergetique et de Mecanique Appliquee (LEMA,), Ecole Polytechnique dAbomey-Calavi, Ecole Doctorale des Sciences de lIngenieur, Universite dAbomey-Calavi, BENIN., Yaya Nadjo Isdeen ,   Laboratoire PIE â€“Ï€ (Procedes Innovants pour Energie Durable, Ecole Superieure des Metiers des Energies Renouvelables (ESMER), BENIN.
Published: April 2022

Stationary energy storage is one of current and major challenge in the world. LiFePO4(LFP) batteries have been used more and more for several applications, stationary energy storage specifically.This technology of batteries is one of promising candidates for power lithium ion batteries due to their flat voltage profile, environmental benignity, cycling stability, and high theoretical capacity. However, the poor electronic conductivity and a low lithium ion diffusion coefficient of LiFePO4 cathode materials are the mains disadvantage which make the researchers to investigate on doping materials. This review summarize the main research which allow to improve electrochemical performance of the LiFePO4 batteries in context of stationary energy storage. The improvement of LiFePO4 batteries is mainly due to the cathode. Li-site doped with particular elements increase the width of the one-dimensional diffusion channels of lithium ions and decrease the charge transfer resistance, which resulted in a good electrochemical performance of doped LiFePO4. Fe-site doping enhance the electronic conductivity of LiFePO4 while O-site doped with proper ion improve the intrinsic conductivity and promote the redox potential of LiFePO4. Furthermore, multi-elements co-doping enhance the electrochemical performances ofLiFePO4cathodes.The more interesting doping are: LiFe0.975Zn0.025PO4,LiV0.069Ti0.025Fe0.905PO4and Li0.99La0.01Fe0.9Mg0.1PO4