bluuebunny/crossref_metadata_2025 huggingface dataset:
A survey of breastfeeding among women with previous surgery for benign breast disease: a descriptive exploratory study
Authors: Mao Siying , He Jiafa , Huang Lezhen , Sun Yang , Dai Yan , Guo Qianqian , Qiu Chang , Song Xue , Lin Xiaojie , Chen Shengying , Ye Lingling , Xu Rui
Published: June 2024

Background

Surgery is the primary treatment for benign breast disease and causes some disruption to the normal physiology of the breast, even when this disruption is localised, it remains unclear whether it affects women’s ability to breastfeed. There are only a few studies describing the experience of breastfeeding in women who have undergone benign breast disease (BBD) surgery.

Methods

We retrospectively analysed data from patients aged 20–40 years in Guangdong, China, who underwent breast lumpectomy for BBD in our department between 01 January 2013 and 30 June 2019, with a follow-up date of 01 February 2022. Patients were included who had a history of childbirth between the time of surgery and the follow-up date. By collecting general information about this group of patients and information about breastfeeding after surgery, we described the breastfeeding outcomes of women of a fertile age who had previously undergone surgery for benign breast disease.

Results

With a median follow-up of 5.9 years, a total of 333 patients met the inclusion criteria. From the breastfeeding data of the first child born postoperatively, the mean duration of ‘exclusive breastfeeding’ was 5.1 months, and the mean duration of ‘any breastfeeding’ was 8.8 months. The rate of ‘ever breastfeeding’ is 91.0%, which is lower than the national average of 93.7%, while the exclusive breastfeeding rate at six months was 40.8%, was higher than the 29.2% national average. The any breastfeeding rate at 12 months was 30.0%, which was well below the 66.5% national average. The common reason for early breastfeeding cessation was insufficient breast milk. A total of 29.0% of patients who had ever breastfed after surgery voluntarily reduced the frequency and duration of breastfeeding on the operated breast because of the surgery.

Conclusions

There are some impacts of BBD surgery on breastfeeding and some may be psychological. Institutions should provide more facilities for mothers who have undergone breast surgery to help them breastfeed, such as conducting community education on breastfeeding after breast surgery, training professional postoperative lactation consultants in hospitals, and extending maternity leave. Families should encourage mothers to breastfeed with both breasts instead of only the non-operated breast.
Novel homozygous frameshift insertion variant in the last exon of the EDARADD causing hypohidrotic ectodermal dysplasia in two siblings: case report and review of the literature
Authors: Kablan Ahmet , Tasdelen Elifcan
Published: June 2024

Background

Hypohidrotic ectodermal dysplasia (HED) is a genetic disorder that results in the abnormal development of structures derived from ectodermal tissue. This rare condition predominantly affects the hair, nails, eccrine glands, and teeth. While HED can be caused by various genes, the EDA, EDAR, EDARADD, and WNT10A genes account for approximately 90% of cases. Notably, HED forms associated with variants in the EDA, EDAR, or EDARADD genes may exhibit similar phenotypes due to defects in a common signaling pathway. Proper interaction among the products of these genes is crucial for the activation of the nuclear factor (NF-κB) signaling pathway, which subsequently regulates the transcription of targeted genes. The EDARADD gene, in particular, harbors one of the rarest reported variants associated with HED.

Case presentation

Five-and two-years-old brothers born into consanguineous parents were examined at our outpatient medical genetics clinic at Sanliurfa Training and Research Hospital, Turkey. Both displayed the same classical phenotypic features of HED. The elder had a very sparse dark and brittle hair, sparse eyebrows and eyelashes, conical upper and lower premolar teeth with hypodontia, widely spaced teeth, very dry skin, mildly prominent forehead, and periorbital wrinkles. The younger one showed the same, but less severe, clinical features. After thorough examination and patient history evaluation, targeted next-generation sequencing analysis yielded the novel homozygous insertion variant c.322_323insCGGGC p.(Arg108ProfsTer7) in EDARADD. The mutation has not been reported to date in the literature.

Conclusions

In this report, we present two siblings exhibiting classical HED symptoms and a novel insertion variant of the EDARADD gene, which leads to a frameshift introducing a stop codon. Both brothers inherited such mutation from their parents, who were heterozygous carriers of the same variant. The present study may shed light about the pathogenic mechanisms underlying HED, and expand the spectrum of EDARADD gene variants associated with this condition.
Effectiveness of janus kinase inhibitors in relapsing giant cell arteritis in real-world clinical practice and review of the literature
Authors: Loricera Javier , Tofade Toluwalase , Prieto-Peña Diana , Romero-Yuste Susana , de Miguel Eugenio , Riveros-Frutos Anne , Ferraz-Amaro Iván , Labrador Eztizen , Maiz Olga , Becerra Elena , Narváez Javier , Galíndez-Agirregoikoa Eva , González-Fernández Ismael , Urruticoechea-Arana Ana , Ramos-Calvo Ángel , López-Gutiérrez Fernando , Castañeda Santos , Unizony Sebastian , Blanco Ricardo
Published: June 2024

Background

A substantial proportion of patients with giant cell arteritis (GCA) relapse despite standard therapy with glucocorticoids, methotrexate and tocilizumab. The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signalling pathway is involved in the pathogenesis of GCA and JAK inhibitors (JAKi) could be a therapeutic alternative. We evaluated the effectiveness of JAKi in relapsing GCA patients in a real-world setting and reviewed available literature.

Methods

Retrospective analysis of GCA patients treated with JAKi for relapsing disease at thirteen centers in Spain and one center in United States (01/2017-12/2022). Outcomes assessed included clinical remission, complete remission and safety. Clinical remission was defined as the absence of GCA signs and symptoms regardless of the erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) values. Complete remission was defined as the absence of GCA signs and symptoms along with normal ESR and CRP values. A systematic literature search for other JAKi-treated GCA cases was conducted.

Results

Thirty-five patients (86% females, mean age 72.3) with relapsing GCA received JAKi therapy (baricitinib, n = 15; tofacitinib, n = 10; upadacitinib, n = 10). Before JAKi therapy, 22 (63%) patients had received conventional synthetic immunosuppressants (e.g., methotrexate), and 30 (86%) biologics (e.g., tocilizumab). After a median (IQR) follow-up of 11 (6-15.5) months, 20 (57%) patients achieved and maintained clinical remission, 16 (46%) patients achieved and maintained complete remission, and 15 (43%) patients discontinued the initial JAKi due to relapse (n = 11 [31%]) or serious adverse events (n = 4 [11%]). A literature search identified another 36 JAKi-treated GCA cases with clinical improvement reported for the majority of them.

Conclusions

This real-world analysis and literature review suggest that JAKi could be effective in GCA, including in patients failing established glucocorticoid-sparing therapies such as tocilizumab and methotrexate. A phase III randomized controlled trial of upadacitinib is currently ongoing (ClinicalTrials.gov ID NCT03725202).
Immunosuppression at ICU admission is not associated with a higher incidence of ICU-acquired bacterial bloodstream infections: the COCONUT study
Authors: Zebian Ghadi , Kreitmann Louis , Houard Marion , Piantoni Antoine , Piga Gaetan , Ruffier des Aimes Sarah , Holik Bérénice , Wallet Frédéric , Labreuche Julien , Nseir Saad
Published: June 2024

Background

Immunosuppression at intensive care unit (ICU) admission has been associated with a higher incidence of ICU-acquired infections, some of them related to opportunistic pathogens. However, the association of immunosuppression with the incidence, microbiology and outcomes of ICU-acquired bacterial bloodstream infections (BSI) has not been thoroughly investigated.

Methods

Retrospective single-centered cohort study in France. All adult patients hospitalized in the ICU of Lille University-affiliated hospital for > 48 h between January 1st and December 31st, 2020, were included, regardless of their immune status. Immunosuppression was defined as active cancer or hematologic malignancy, neutropenia, hematopoietic stem cell and solid organ transplants, use of steroids or immunosuppressive drugs, human immunodeficiency virus infection and genetic immune deficiency. The primary objective was to compare the 28-day cumulative incidence of ICU-acquired bacterial BSI between immunocompromised and non-immunocompromised patients. Secondary objectives were to assess the microbiology and outcomes of ICU-acquired bacterial BSI in the two groups.

Results

A total of 1313 patients (66.9% males, median age 62 years) were included. Among them, 271 (20.6%) were immunocompromised at ICU admission. Severity scores at admission, the use of invasive devices and antibiotic exposure during ICU stay were comparable between groups. Both prior to and after adjustment for pre‐specified baseline confounders, the 28-day cumulative incidence of ICU-acquired bacterial BSI was not statistically different between immunocompromised and non-immunocompromised patients. The distribution of bacteria was comparable between groups, with a majority of Gram-negative bacilli (~ 64.1%). The proportion of multidrug-resistant bacteria was also similar between groups. Occurrence of ICU-acquired bacterial BSI was associated with a longer ICU length-of-stay and a longer duration of invasive mechanical ventilation, with no significant association with mortality. Immune status did not modify the association between occurrence of ICU-acquired bacterial BSI and these outcomes.

Conclusion

The 28-day cumulative incidence of ICU-acquired bacterial BSI was not statistically different between patients with and without immunosuppression at ICU admission.
On steady state of viscous compressible heat conducting full magnetohydrodynamic equations
Authors: Azouz Mohamed , Benabidallah Rachid , Ebobisse François
Published: June 2024

This paper is concerned with the study of equations of viscous compressible and heat-conducting full magnetohydrodynamic (MHD) steady flows in a horizontal layer under the gravitational force and a large temperature gradient across the layer. We assume as boundary conditions, periodic conditions in the horizontal directions, while in the vertical directions, slip-boundary is assumed for the velocity, vertical conditions for the magnetic field, and fixed temperature or fixed heat flux are prescribed for the temperature. The existence of stationary solution in a small neighborhood of a stationary profile close to hydrostatic state is obtained in Sobolev spaces as a fixed point of some nonlinear operator.
Retraction Note: Asiaticoside, a trisaccaride triterpene induces biochemical and molecular variations in brain of mice with parkinsonism
Authors: Sampath Uvarajan , Arambakkam Janardhanam Vanisree
Published: June 2024

This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/2047-9158-2-23.
A color prediction model for mending materials of the Yuquan Iron Pagoda in China based on machine learning
Authors: Liu Xuegang , Liu Yuhang , Wang Ke , Zhang Yang , Lei Yang , An Hai , Wang Mingqiang , Chen Yuqiu
Published: June 2024

During the restoration of iron cultural relics, the removal of rust from these artifacts is necessary. However, this rust removal process may lead to inconsistent local color on the iron relics. To address this, mending materials are applied to treat the surface, ensuring consistent local color. In the surface treatment of iron cultural relics, a significant challenge lies in modulating the color of these mending materials. The corrosion products of Yuquan Iron Pagoda are mainly Fe3O4, γ-FeO(OH), α-FeO(OH) and α-Fe2O3, with contents of 13.1, 16.1, 40.2 and 30.6%, respectively. Due to their structural stability and suitable color characteristics, Fe3O4 and α-Fe2O3 are selected as the primary raw materials for the repair material. This study employs machine learning methods to predict the color of mending materials corresponding to varying contents of α-Fe2O3, Fe3O4, and epoxy resin. The Artificial Neural Network (ANN), eXtreme Gradient Boosting (XGBoost), and Light Gradient Boost Machine (LightGBM) algorithms are utilized to develop the model, and the predictive performance of these three algorithms is compared. XGBoost exhibits the best prediction performance, achieving a square correlation coefficient (R2) of 0.94238 and a mean absolute error (MAE) of 0.68485. Additionally, the SHapley Additive exPlanations (SHAP) method is employed to analyze the most crucial raw material affecting the color of mending materials, which is identified as Fe3O4. The study illustrates the specific process of employing this model by applying it to the surface treatment of the Yuquan Iron Pagoda, demonstrating the practicality of the model. This model can be applied to assist in the surface treatment of other iron cultural relics.
Footprint-driven stochastic approximation inversion for time-domain airborne electromagnetic data
Authors: Ren Xiuyan , Lai Mingquan , Wang Luyuan , Yin Changchun , Liu Yunhe , Su Yang , Zhang Bo
Published: June 2024

The airborne electromagnetic (AEM) method can be used to effectively explore underground conductivity structures at high resolution. Conventional 3D AEM inversions are mainly based on gradient-type deterministic methods; however, their results cannot be evaluated without bias because they only provide an updated model from an initial model. Here, we develop a footprint-driven stochastic approximation (FSA) method for 3D time-domain AEM inversion. We first adopt a compressed-sensing strategy to speed up the forward-modeling process, where random K-set ([Formula: see text]) data are sampled with a preset sampling rate to guarantee a high-precision reconstruction. Then, we establish K sets of stochastic inversion equations with a preconditioner consisting of the sampling rate and gradient noise and produce K different updates that have different focuses on the underground structure. The final model update in each iteration is obtained using a footprint-driven averaging technique that first considers the contributions of K-set models on the underground structures in terms of AEM footprint and then uses the mean value and standard deviation to determine whether each model is accepted or rejected. Numerical experiments indicate that the K updates of the FSA inversion gradually reveal similar structures as the inversion proceeds. The small uncertainty and acceptable relative accuracy further demonstrate the efficacy of our parameter selection strategy. As such, the method can provide a reliable conductivity distribution with uncertainty for synthetic data and a practical model from the Lisheen sulfide deposit.
Overall survival (OS) of phase 3 CodeBreaK 300 study of sotorasib plus panitumumab (soto+pani) versus investigator’s choice of therapy for KRAS G12C-mutated metastatic colorectal cancer (mCRC).
Authors: Fakih Marwan , Salvatore Lisa , Esaki Taito , Modest Dominik Paul , Páez Lopez-Bravo David , Taieb Julien , Karamouzis Michalis , Ruiz-Garcia Erika , Kim Tae Won , Kuboki Yasutoshi , Meriggi Fausto Angelo , Cunningham David , Yeh Kun-Huei , Chan Emily , Chao Joseph , Tran Qui , Cremolini Chiara , Pietrantonio Filippo
Published: June 2024

LBA3510

Background: In CodeBreaK 300 (NCT05198934), soto+pani was superior to investigator’s choice at the primary analysis of progression-free survival (PFS) in patients (pts) with chemorefractory KRAS G12C-mutated mCRC (Fakih et al. NEJM. 2023). OS data were immature at the PFS analysis. We now report the final OS analysis of CodeBreaK 300. Methods: Study procedures and eligibility criteria were previously reported. The PFS primary endpoint was tested at primary analysis. Key secondary endpoints included OS and objective response. Though the study sample size was not powered for OS, OS hypothesis testing using stratified log-rank test was planned when 50% of pts had observed events per protocol. Stratified Cox hazard ratio (HR) and Kaplan-Meier median estimates are provided. Results: In total, 160 pts were randomly assigned 1:1:1 to soto960+pani (n=53), soto240+pani (n=53), or investigator’s choice of trifluridine/tipiracil, or regorafenib (investigator’s choice; n=54). As of Dec 18, 2023, with a median follow-up of 13.6 months, 82 deaths had occurred with 24, 28, and 30 deaths in the soto960+pani, soto240+pani, and investigator’s choice arms, respectively. Median OS (95% CI) was not reached for soto960+pani, 11.9 months (7.5, NE) for soto240+pani, and 10.3 months (7.0, NE) for investigator’s choice. Hazard ratio (95% CI) was 0.70 (0.41, 1.18) for soto960+pani compared to investigator’s choice and 0.83 (0.49, 1.39) for soto240+pani compared to investigator’s choice. Updated ORR, DOR, and DCR are included in Table. No new safety signals were observed. Conclusions: While CodeBreaK 300 was not powered to detect a statistically significant difference in OS, the study showed a trend toward improved OS for patients randomized to soto960+pani. Together with PFS and response rates, these results support the use of soto960+pani as a potential SOC for pts with chemorefractory KRAS G12C-mutated mCRC. Acknowledgements: The authors thank the patients, investigators, and study staff who contributed to this study; The study was sponsored and funded by Amgen Inc.; Medical writing support was provided by Shubha Dastidar, PhD (CACTUS) and Christopher Nosala, PhD (Amgen Inc.). Clinical trial information: NCT05198934 . [Table: see text]
Phase III randomized trial evaluating tilsotolimod in combination with ipilimumab versus ipilimumab alone in patients with advanced refractory melanoma (ILLUMINATE 301).
Authors: Diab Adi , Ascierto Paolo Antonio , Abdel-Wahab Reham , Maio Michele , Negrier Sylvie , Mortier Laurent , Dalle Stéphane , Krajsova Ivana , de la Cruz Luis , Leccia Marie Thérèse , Guida Michele , Lebbe Celeste , Grob Jean-Jacques , Butler Marcus O. , In Gino Kim , Chunduru Srinivas , Rahimian Shah , Robert Caroline
Published: June 2024

LBA9516

Background: There are limited treatment options for advanced melanoma that has progressed during or after immune checkpoint inhibitor therapy. Intratumoral (IT) immunotherapy may improve tumor-specific immune activation by promoting local tumor antigen presentation while avoiding systemic toxicities. The Phase 3 ILLUMINATE-301 study (NCT03445533) evaluated tilsotolimod, a toll-like receptor 9 agonist, with or without ipilimumab in patients with anti-programmed death-1 (PD-1)-advanced refractory melanoma. Methods: Patients with unresectable Stage III–IV melanoma that progressed during or after anti-PD-1 therapy were randomized 1:1 to receive 24 weeks of tilsotolimod plus ipilimumab or 10 weeks of ipilimumab alone. Nine IT injections of tilsotolimod were administered to a single designated lesion over 24 weeks. Intravenous ipilimumab 3 mg/kg was administered every 3 weeks from Week 2 in the tilsotolimod arm and Week 1 in the ipilimumab arm. The primary endpoint was efficacy measured using objective response rate (ORR; independent review) and overall survival (OS). Results: A total of481 patients received tilsotolimod plus ipilimumab (n = 238) or ipilimumab alone (n = 243). ORRs were 8.8% in the tilsotolimod arm and 8.6% in the ipilimumab arm, with disease control rates of 34.5% and 27.2%, respectively. Median OS was 11.6 months in the tilsotolimod arm and 10.0 months in the ipilimumab arm (hazard ratio (HR) 0.96 [95% confidence interval (CI) 0.77–1.19]; P = 0.7). Grade ≥3 treatment-emergent adverse events occurred in 61.1% and 55.5% of patients in the tilsotolimod and ipilimumab arms, respectively. Conclusion: Adding tilsotolimod to ipilimumab did not improve response or OS in patients with PD-1 refractory advanced melanoma. However, the results represent the largest prospective dataset reported to date on using ipilimumab in this setting and are a valuable addition to the knowledge base. Clinical trial information: NCT03445533 .
Model-based machine learning of critical brain dynamics
Authors: Bocaccio Hernán , Tagliazucchi Enzo
Published: June 2024

Criticality can be exactly demonstrated in certain models of brain activity, yet it remains challenging to identify in empirical data. We trained a fully connected deep neural network to learn the phases of an excitable model unfolding on the anatomical connectome of human brain. This network was then applied to brain-wide fMRI data acquired during the descent from wakefulness to deep sleep. We report high correlation between the predicted proximity to the critical point and the exponents of cluster size distributions, indicative of subcritical dynamics. This result demonstrates that conceptual models can be leveraged to identify the dynamical regime of real neural systems.
Serotonin Syndrome After Prolonged Remifentanil and Propofol Infusion for Craniotomy: A Case Report
Authors: Kabil Emmad W. , Lunardi Nadia , Tennant William G. , Esfahani Kamilla
Published: June 2024

Serotonin syndrome (SS) is a life-threatening condition caused by serotonergic medications. We describe a unique case of SS likely caused by prolonged exposure to propofol and remifentanil alone. A young male presented for vestibular schwannoma resection. Several hours into the case, the patient demonstrated hyperthermia and hemodynamic instability, followed by clonus, rigidity, shivering, and tachycardia after emergence. SS was diagnosed using Hunter’s criteria and improved with supportive measures. While the patient endorsed a history of methamphetamine use, his urine drug screen was negative. The possibility of SS should be considered when administering propofol and remifentanil, particularly with prolonged infusions.
Why Some Nonelderly Adult Medicaid Enrollees Appear Ineligible Based on Their Annual Income
Authors: Kim Geena , Minicozzi Alexandra , White Chapin
Published: June 2024

Context: Recent studies have highlighted Medicaid enrollment among middle- and higher-income populations and questioned whether the program is reaching those for whom it is intended.

Methods: The authors use administrative tax data to measure Medicaid enrollment and income in 2017, they use survey data to measure monthly income, and they use administrative data to identify Medicaid enrollment pathways.

Findings: Among 38.8 million nonelderly adults in Medicaid at any point in 2017, 24.4 million had annual income below their state's typical eligibility threshold, and 14.4 million (37%) had income above the threshold. Among those above the threshold, 3.5 million enrolled through a pathway allowing higher income (pregnant women, the “medically needy,” and others). The authors also estimate that more than 12 million had at least one month with income below the threshold, and roughly 4 million had at least five months with income below the eligibility threshold.

Conclusions: Pathways allowing higher income account for one quarter of enrollees with annual incomes above typical thresholds. Among low-income adults, month-to-month variation in income is common and can account for most or all of the remaining enrollees with annual incomes above typical thresholds. A complete accounting of eligibility status would require merged data on income, Medicaid enrollment, and family structure.
Ensino jurídico e os novos anseios do século XXI: atividades extensionistas
Authors: Aragão Feitosa Léa , Rolim Peixoto Arnelle
Published: June 2024

Apresenta-se o estudo sobre novos anseios da sociedade no que tange à experiência acadêmica no Ensino Superior, abordando a extensão universitária pela análise do novo marco regulatório, a Resolução CNE/CES n. 7/2018 do Ministério da Educação. Tem-se o objetivo de analisar o cenário atual das atividades extensionistas, com recorte para o desenvolvimento do acadêmico e a atividade cidadã em promoção humana. A metodologia da pesquisa é bibliográfica, com abordagem qualitativa e exploratória, mediante análise de artigos científicos, da Constituição Federal e da Resolução CNE/CES n.7/2018 do Ministério da Educação. Defende-se o aspecto positivo da implementação das atividades extensionistas junto à comunidade, capacitando o aluno para o ambiente profissional, por meio da informação compartilhada, em especial no Curso de Direito, conscientizando e resguardando de violações a interesses protegidos, interferindo em benefício da sociedade.
Novas perspectivas do ensino jurídico do direito penal
Authors: Isidoro David
Published: June 2024

O paradigma vigente de instrução nas instituições de ensino jurídico reflete uma abordagem convencional, caracterizada por métodos cartesianos de transmissão de conhecimento. Nesse contexto, sustenta-se a importância crucial de fomentar metodologias inovadoras com o propósito de modernizar o sistema educacional jurídico. A evolução do ensino jurídico demanda que os docentes superem o desafio de envolver os estudantes e concorrer com os recursos tecnológicos à disposição. Diante dessa imperiosa necessidade, a utilização de visitas técnicas e a realização de júri simulado representam uma forma eficaz para promover um aprendizado eficiente e a descoberta de talentos. É de suma importância refletir sobre a disseminação de novas possibilidades de ensino no âmbito das faculdades de Direito e investigar estratégias para implementar esses novos métodos como uma abordagem pedagógica. Ao abordar a premência dessa reflexão, o estudo almeja contribuir para a transformação do ensino jurídico.
Επειδή όταν σε κοιτώ
Authors: Αντωνόπουλος Παναγιώτης
Published: June 2024

Η παρουσία της Σαπφώς στη νεοελληνική γραμματεία καλύπτει ένα ευρύ φάσμα βιβλιογραφικών αναφορών. Από φιλολογικά κείμενα, ευρωπαϊκές και νεοελληνικές εκδόσεις και μεταφράσεις των αποσπασμάτων της, μέχρι ποιήματα (στα ελληνικά ή σε άλλες ευρωπαϊκές γλώσσες) που εμπνέονται από το πρόσωπο ή το έργο της Σαπφώς. Η ανάλυση της ποίησής της σε ξεχωριστά κεφάλαια υπήρξε απαραίτητη, για να τονιστεί η διαφορά ανάμεσα στην αρχαία Σαπφώ και στην εικόνα που σχηματίζει ο νεότερος κόσμος γι' αυτήν. Γιατί κάθε εποχή κατασκευάζει τη δική της Σαπφώ σύμφωνα με τις δικές της αισθητικές και ηθικές αρχές: από την "αγνή" Σαπφώ μέχρι τη λεσβία Σαπφώ, από τον ρομαντισμό μέχρι τον μοντερνισμό, η αρχαία ποιήτρια γίνεται όχημα για την αποτύπωση είτε παραδοσιακών είτε ανατρεπτικών εκδοχών της ανθρώπινης σεξουαλικότητας. Γι' αυτόν τον λόγο, η μελέτη δεν περιορίζεται στην πραγμάτευση μόνο της νεοελληνικής Σαπφώς, αλλά επεκτείνεται και στα σαπφικά έργα που εντοπίζονται στην υπόλοιπη ευρωπαϊκή γραμματεία από την οποία Νεοέλληνες φιλόλογοι και ποιητές αντλούν τα παραδείγματά τους. Πρόκειται, λοιπόν, για μια μελέτη που εντάσσεται στο πεδίο της συγκριτικής φιλολογίας.
Relationship between benzene concentration, MDA levels and kidney function in car painting workshops in Surabaya: A cross-sectional observational study
Authors: Tualeka Abdul Rohim , Aziz Mohd Yusmaidie , Perumal Velu , Thamaraikani Tamilanban , Rosnon Roslan , Novianti Salsabila , Rahmawati Pudji , Ahsan Ahsan
Published: June 2024

Background Car painting workers are at risk because of the use of solvents containing benzene as the main ingredient in the car painting process. One of the clinical effects of systemic benzene is kidney disorders. Therefore, the purpose of this study is to analyze the relationship between benzene and Risk Quotient (RQ) benzene concentrations with Malondialdehyde (MDA), Blood Urea Nitrogen (BUN), and creatinine levels in workers exposed to benzene in car painting workshops in Surabaya. Methods This study used an observational design with a cross-sectional method conducted at two car paint workshops in Surabaya. The study population was all workers exposed to benzene in the two car paint workshops, aged between 20-65 years in 2019. The sample was taken using an accidental sampling method, involving 30 respondents. Inclusion criteria included workers exposed to benzene and willing to participate, while exclusion criteria included workers with a liver or kidney disease history. The variables studied included benzene concentration, benzene RQ (benzene metabolite), malondialdehyde (MDA) levels as a marker of oxidative stress, and indicators of kidney function (BUN and creatinine levels). Data were analyzed using descriptive and bivariate analysis with Pearson correlation test. Results There was no significant relationship between concentrations, RQ benzene, and MDA levels in workers in painting in Surabaya (p> 0.05). There was no significant relationship between benzene concentration, BUN levels, and creatinine levels in paint workers in Surabaya (p> 0.05). There was no significant relationship between benzene RQ and BUN and creatinine levels in paint workers in Surabaya (p> 0.05). Conclusions This study's results indicate that benzene's effects do not lead to impaired kidney function. The benzene RQ variable in this study did not become a determining factor in BUN and creatinine levels in workers.
Active Historical Memory Within the Framework of Patriotic Education of Student Youth
Authors: Mizyurova E. , Mikheeva Olga , Mizyurov S.
Published: June 2024

The author of the article notes the relevance of the process of educating young people in modern higher education. In conditions of information oversaturation, student youth do not always correctly perceive the events of historical history. The author of the article defines active historical memory as the foundation of patriotic education. In connection with the announcement of the year 2024 - the year of the family, the article analyzes the importance of family values, family traditions for young people. The goal presented in the article, the patriotic project “I bow to women’s hands to the ground” was achieved thanks to the unity of memory of family traditions and memory of the history of the hometown.
Relaciones posibles entre temporalidad y paisaje lingüístico en español.
Authors: Sáez Rivera Daniel M.
Published: June 2024

Definida la temporalidad filosóficamente como «consciencia del presente que permite enlazar con el pasado y con el futuro», nos proponemos explorar las posibles relaciones del tiempo con el Paisaje Lingüístico (PL) en español mediante la revisión de la bibliografía al uso, la reflexión propia y la toma de fotografías ilustrativas en diferentes puntos de España. El resultado detecta tres vías principales de relaciones posibles entre temporalidad y paisaje lingüístico en español: 1) historiografía del PL, esto es, cómo surgen los estudios de PL del mundo hispánico, desde un principio anecdótico a la consolidación actual de toda una disciplina; 2) PL diacrónico, mirada centrada en el estudio del paso del tiempo conforme se refleja en el PL, de mutación normalmente muy rápida, dentro de la cual tipificaremos algunos tipos de cambio habituales; 3) diacronía en el PL, en tanto en cuanto se conservan signos de etapas pasadas del español.
Pronombres personales y género gramatical en español.
Authors: Devís Márquez Pedro Pablo
Published: June 2024

La noción de género como rasgo inherente de sustantivos y pronombres manifestado mediante la concordancia ocasiona problemas en la caracterización y clasificación que la gramática española hace de los pronombres personales según esta categoría. Nuestro planteamiento parte de la identificación de esos problemas, de una reflexión crítica sobre esa concepción del género y de una consideración alternativa de este como categoría que proporciona información, en el ámbito de la designación virtual, sobre la delimitación de clases —no siempre relacionadas con el sexo— incluidas en otra de mayor extensión. Finalmente, abordamos el objetivo básico de este artículo: la caracterización y clasificación de los pronombres personales en español según esta noción alternativa del género gramatical.
La ironía en la fraseodidáctica: el caso de las locuciones verbales en estudiantes rusos de ELE.
Authors: Ramírez Rodríguez Pablo
Published: June 2024

Uno de los problemas actuales en el campo de la didáctica está relacionado con los métodos de adquisición a la hora de aprender lenguas extranjeras. La ironía, por su parte, desempeña un papel didáctico en la enseñanza-aprendizaje de unidades fraseológicas (UF) de cara a resaltar el significado y el uso de estas, de forma que resulte atractiva y fácil de recordar para el alumnado. Al inyectar humor e ironía en el aula se crea un ambiente de aprendizaje más relajado y ameno, lo que ayuda al alumnado a retener mejor la información. La presente investigación se enfoca en la importancia de la ironía como estrategia para el estudio de la fraseodidáctica en el aula de español como lengua extranjera (ELE) y se marca como objetivo analizar la percepción de la ironía que entrañan ciertas locuciones verbales (LV) idiomáticas en español por parte del alumnado ruso, así como su correcta interpretación y posibles efectos en el proceso didáctico. De este modo, con el propósito de avalar con mayor rigor las investigaciones existentes acerca del recurso irónico en el aula, surge el objetivo de la investigación, enfocado en conocer y dar cuenta de la relación entre ironía, didáctica y fraseología. Tras analizar el elemento pragmático de la ironía, así como los diversos tipos de esta dentro del universo fraseológico se llega a la conclusión, mediante una prueba tipo test compuesta por locuciones verbales (LV) enmarcadas en contextos irónicos, de que su inclusión en el aula puede resultar fructífera para los estudiantes.
Agrosembradores del macizo colombiano: reforestar la cabeza y el territorio. Luchas y reexistencias en el Cauca
Authors: Corredor Jiménez Carlos Enrique
Published: June 2024

Las escuelas agroambientales del macizo colombiano son la propuesta política organizativa construida en el Comité de Integración el Macizo Colombiano (Cima) para plantear su horizonte de vida digna. Son una opción política de reexistencia; en su conformación hay un camino de altibajos y retos que aún sigue en proceso, su experiencia retoma, de múltiples maneras, aportes de la agroecología y se busca que se lo entienda como un movimiento de ecología popular en el amplio panorama de la lucha social y ambiental que se da en el Cauca profundo.
Dossier de aportes para la educación rural; pedagogías para la co-existencia
Authors: Arias Naranjo María Angélica
Published: June 2024

Saramago habla del silencio en La caverna, y este verso permite entender que las personas somos silencios. Eso sí, hay unos silencios más largos que otros, y el de las personas que habitan el campo ha durado décadas. En la actualidad, son varias las apuestas colectivas que se encargan de entablar un diálogo con el campo, de entender su silencio y de compartir saberes desde la palabra. En este apartado se conocerán cuatro de estos procesos pedagógicos en los cuales se busca acabar con el extenso silencio de la ruralidad colombiana. Así, el objetivo de este documento es evidenciar las labores colectivas que se hacen desde abajo y hacia todas las direcciones para promover el desarrollo rural en nuestro país.
Una mirada en torno a la realidad de las mujeres migrantes en materia de derechos humanos desde el contexto internacional al nacional
Authors: Palacios Sanabria María Teresa , Torres Villarreal María Lucía , González Tamayo Nicolás
Published: June 2024

En este capítulo del libro La mujer migrante en Colombia: análisis de sus derechos humanos desde el contexto regional, 2014- 2018 se aporta un contexto normativo desde dos ejes fundamentales. Por un lado, se efectúa un análisis del amparo de la mujer migrante en el contexto internacional a partir de dos perspectivas: i) desde el reconocimiento de los derechos en los instrumentos del sistema universal de protección de derechos humanos, así como del sistema regional interamericano y ii) desde el desarrollo de la jurisprudencia de derecho flexible emanada de los órganos de los tratados en el seno de las Naciones Unidas y de los mandatos de los relatores especiales del orden universal y regional interamericano1 . De otro lado, se formula una reflexión desde el contexto nacional colombiano, a partir de un análisis de la normatividad existente en materia de migración y de su relación con la protección de los derechos de las mujeres migrantes y, así mismo, desde la aplicación del denominado bloque de constitucionalidad como norma rectora del ordenamiento jurídico instituido desde 1991, con ocasión de las sentencias proferidas por la Corte Constitucional en el escenario de la migración.
On the Simplex Method for 0/1-Polytopes
Authors: Black Alexander E. , De Loera Jesús A. , Kafer Sean , Sanità Laura
Published: June 2024

We present three new pivot rules for the Simplex method for Linear Programs over 0/1-polytopes. We show that the number of nondegenerate steps taken using these three rules is strongly polynomial, linear in the number of variables, and linear in the dimension. Our bounds on the number of steps are asymptotically optimal on several well-known combinatorial polytopes. Our analysis is based on the geometry of 0/1-polytopes and novel modifications to the classical steepest-edge and shadow-vertex pivot rules. We draw interesting connections between our pivot rules and other well-known algorithms in combinatorial optimization.

Funding: A. E. Black and J. A. De Loera are grateful for the support received through the National Science Foundation [Grants DMS-1818969 and NSF GRFP]. L. Sanita is grateful for the support received from the Nederlandse Organisatie voor Wetenschappelijk Onderzoek [Grant VI.Vidi.193.087].
Chronological Problems of the Adana Taşköprü
Authors: GÖÇMEN İlkay
Published: June 2024

One of the most important settlements of Cilicia, which is an important connection point between East and West, is Adana. The international road route, which reaches Tarsus and then Adana via Gülek, turns east from here. Located on this route, Taşköprü (= Stone Bridge) provides a connection over the Sarus river. Although the arches of the bridge, which consists of twenty-one spans together with the discharging arches, vary in form, the architectural style generally exhibits Roman features. The bridge, which is known to have been repaired many times after the first construction, contains arches from different periods as well as early period remains. Although it is generally accepted that its construction was carried out in the Roman Period, it is controversial when exactly it should be dated to and which Imperial period. Some researchers associate the bridge with the historical context and date it to the Hadrianic Period. On the other hand, a group of researchers think that the bridge was built in the IVth century A.D., based on the name of the Architect Auxentios mentioned in the inscription. The aim of the study is to make a new proposal about when Taşköprü was built. Considering the importance of the road it connects and the political process, it turns out that both dates suggested for the structure are too late. In addition, the discharging arches on the bridge piers allow for a more accurate dating of the structure. In short, considering the architectural features and the political process, it becomes possible to determine the construction date of the bridge and to make a new proposal.
The Soap Factory Building: An Example of Industrial Heritage in Ayvalık
Authors: İGÜS Esma
Published: June 2024

This study concerns a soap factory built in the early years of the twentieth century in Ayvalık Soap factories which are described within the scope of immovable industrial assets of the region, are substantial in terms of the commercial life of Ayvalık, just like the olive oil factories. Soap factories having a crucial role in the industry-based spatial history of Ayvalık, are reviewed in two main groups according to their structure. The first group includes soap factories which were built as individual single buildings. The second group includes soap factories, each of which was built adjacent to an olive oil factory looking like its twin. Many of the soap factories are today either abandoned or being used as cafes, hotels, stores etc. as a result of repurposing. The soap factory forming the subject of this article is located in the 150 Evler District, on the historical industrial manufacturing axis of Ayvalık. Therefore the factory is in an area of Ayvalık which is considered to be hectic in terms of production and trading in its time. Respectively, field research, archival research and a literature review were performed in this study. As a result of the data obtained and finds the soap factory was evaluated in the context of historicity within the framework of architecture and art history disciplines and was analyzed in terms of mass and structure aspects
Iron Age Ceramics of the Uylupınar (Early Cibyra) Settlement
Authors: DÖKÜ F. Eray , ÇOMAK Derya
Published: June 2024

Uylupınar/Göl Adası yerleşimi Burdur ilinin Gölhisar ilçesinin 18 km güneydoğusunda, Uylupınar Gölü’nün kuzeydoğusunda bulunan ve Şehertaşı olarak adlandırılan yerleşimdir. Uylupınar yüzey araştırmasında ele geçen örnekler üzerinde yapılan incelemelerde yerleşimin çevre bölgeler ile etkileşimi söz konusudur. Uylupınar ve çevresindeki yerleşimlerde yapılan araştırmalarda Geometrik Stil, Orientalizan Stil, Yaban Keçisi Stil etkisinde yapılan örnekler mevcuttur. Bu örnekler içerisinde Geometrik, Orientalizan Dönem, Arkaik Dönem seramiklerinde yapılan iç içe çember bezemeli, çizgi bezemeli, zikzak, üçgen, saç örgüsü, giyoş, gamalı haç, balık pulu, mermer taklidi bezemeli kaplar incelenmiştir. Bitkisel bezemeler palmet, yonca rozetidir. Hayvan figürlü örneklerde kaz, köpek, yaban keçisi figürleri ele alınmıştır. Uylupınar yerleşiminde ele geçen örnekler İonia, Lydia, Phrygia etkili olarak üretilen ve yerel üretim örnekler olarak belirlenmiştir. Bu yerleşimde Geometrik ve Arkaik Dönem olarak ele geçen örnekler kronoloji olarak MÖ VII-VI. yüzyıl aralığına tarihlendirilmiştir.
Geç Roma Cumhuriyeti Dönemi nden Seçkin Bir Devlet Adamı: P. Servilius Vatia Isauricus
Authors: KURT Mehmet , KARAKUŞ Engin
Published: June 2024

P. Servilius Vatia Isauricus, who bore witness to a large part of the Late Republic Era and went on to have a long and successful military and political career during this time, has an important place in republican Roman history. Because he is one of the last major Roman statesmen of the traditional kind. Just like the famous Romans of the past, P. Servilius Vatia Isauricus too had gained his political influence within legal boundaries and had never put himself above the Senatus. However, his life had coincided with a period in Roman politics when mighty personalities with great military and political power had emerged, and he had inevitably been overshadowed in terms of reputation by such people. As a matter of fact, there is no comprehensive study that deals entirely with his life, even in modern historiography, contrary to these mighty personalities, about whom countless studies have been written from antiquity to the present. The aim of this study is to fill this gap in the literature to some extent.
The Character of Time in Sir Gawain and the Green Knight
Authors: Weaver Hannah
Published: June 2024

Abstract: The fourteenth-century poem Sir Gawain and the Green Knight shows how an idiosyncratic literary text can open new ways of thinking about that unruly topic, time. Through close readings of the poem and its sole surviving manuscript, I demonstrate how Gawain elaborates its own vision of dynamic, social time in its descriptions of time and characters. Through its evasion of teleologies, the poem offers a critique of discourses of inevitability. Gawain complicates an already complex picture of medieval time-schemes, demonstrating how literary works can add nuance to our understanding of how medieval time worked.
Late Smith and the African's War Dance: Contested Values and Temporalities In Liberal Aesthetics
Authors: Newman Steve
Published: June 2024

Abstract: Adam Smith's often overlooked "Of the Nature of that Imitation which Takes Place in What Are Called the Imitative Arts" (1795) reveals his innovative understanding of the overlaps and conflicts in valuation in the emerging discourses of aesthetics, moral philosophy, and political economy. Placing his praise for an African performing a war-dance in the context of eighteenth-century aesthetic theory and representations of Africans (including Olaudah Equiano's Interesting Narrative [1789]) clarifies current debates over the viability of liberal modes of valuation and cultural pluralism in a post-Enlightenment world grappling with the implications of imperialist violence, especially the Transatlantic trade in enslaved people.
Black Epistemologies and Music: A Dialogue with Emicida's Sobre crianças, quadris, pesadelos e lições de casa
Authors: Abreu Mariana
Published: June 2024

Abstract: The arts have consistently been interlocutors for Black scholarship in the humanities. Poetry, literature, and music are sources of knowledge for theorizing social realities. This relates to two elements: (a) an epistemology that values the production and spread of oral, subjective, and aesthetic forms of knowledge; (b) the systematic exclusion of Black people from academic spaces, especially in Latin American contexts, which encourages alternative practices of reflection and registry. Many artists actively consider what is produced in the cultural margins to be a strong locus of political and intellectual creativity. In Brazil, the rapper Emicida has been trying to make his artistic projects catalysts for philosophical reflection. His album Sobre crianças, quadris, pesadelos e lições de casa resonates with Asian, African, Black Atlantic, and Latin American sources of knowledge including religious practices, pop culture, and philosophy. It discusses themes such as love, race, racism, history, family, environmental crisis, and work relations through the combination of musical styles from Brazil, specifically, and the Black Atlantic, more generally. This article establishes a dialogue with the theories and debates suggested by this album, thus situating its contribution to Black scholarship and epistemology.
All-optical multichannel switch and slow light based on dynamically tunable plasmon-induced transparency
Authors: Zhu Zihao , Yi Xunong
Published: June 2024

The triple plasmon-induced transparency (PIT) effect based on a
metal–insulator–metal waveguide structure comprising two groups of
big and small disk resonators (BSDRs) is investigated theoretically
and numerically. As a tool employed to explain the PIT, N-order coupled mode theory (CMT), is
established, and the calculated results of the triple-PIT effect
exhibit excellent consistency with finite-difference time-domain
simulations. The influence of the separation between the small disk
resonators on the triple-PIT response is discussed in detail through
the dynamical equation. Further research shows that the central
wavelengths of the triple-PIT transmission window can be adjusted with
extremely low pump intensity and ultrafast optical response when
monolayer graphene covers the surface of the BSDRs. Meaningfully,
light traveling at resonant wavelengths can be effectively slowed
down, with the highest group index reaching 368. Based on the PIT
effect, a low-power and ultrafast switch is realized with a modulation
amplitude of more than 93% at the corresponding wavelengths of the
eight depressions. Thus, not only do the insights put forward new
ideas, to the best of our knowledge, for highly tunable optoelectronic
devices, but the results from the N-order CMT also offer new theory
progress and references in the plasmonic waveguide structures.