bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative Analysis and Experimental Verification of a Linear Tubular Generator for Wave Energy Conversion
Authors: Xia Tao , Yu Haitao , Shi Zhenchuan , Guo Rong
Published: July 2018

To improve the power density and reliability of radial (RS-TLPMG) and quasi-Halbach (QH-TLPMG) magnetization tubular linear surface-mounted permanent magnet generators under realistic sea-state conditions, a novel tubular linear generator with multilayer interior permanent magnets (MI-TLPMG) for wave energy conversion is proposed and analyzed in this paper. Using finite element analysis (FEA), a comprehensive comparison of air gap flux density, flux linkage, back electromotive force (back-EMF), load, and no-load performance is investigated to verify the advantages of the proposed machine. The FEA results indicate that MI-LTPMG with a flux-concentrating effect has higher back-EMF, air gap magnetic flux density, flux linkage, and output power than do the other two machines. Finally, a prototype is manufactured and measured on the test platform and wave tank. The experiment and simulation results show a great agreement with each other.
A Simplified Calculation Method for Building Envelope Cooling Loads in Central South China
Authors: Wang Ping , Gong Guangcai , Zhou Yan , Qin Bin
Published: July 2018

The cooling load calculation of building envelopes is important for building design to realize building energy efficiency. A simplified way to predict the building envelope cooling loads is desperately needed to predict the cooling load of building envelopes with various construction layouts and to predict the energy-saving effect of various reconstruction measures for buildings. In light of this need a simplified calculation model for building envelope cooling loads is proposed in this paper. The model is based on dynamic hourly calculations using EnergyPlus. It considers almost all the thermal factors about the building envelope which may affect the building cooling load and it is studied by dimensional analysis. The equivalent window to wall ratio (EWWR) and building orientation factor are defined to study the building envelope cooling load. The cooling loads of twenty hypothetical buildings with various envelopes are predicated by EnergyPlus. With the results from EnergyPlus the simplified calculation model is developed by MATLAB. Then the newly developed model is validated by two typical actual buildings located in Central-South China. The results show the model is accurate enough to predict the building envelope cooling loads.
Hydraulic Fracturing Treatment Optimization for Low Permeability Reservoirs Based on Unified Fracture Design
Authors: Ai Kun , Duan Longchen , Gao Hui , Jia Guangliang
Published: July 2018

Hydraulic fracturing optimization is very important for low permeability reservoir stimulation and development. This paper couples the fracturing treatment optimization with fracture geometry optimization in order to maximize the dimensionless productivity index. The optimal fracture dimensions and optimal dimensionless fracture conductivity, given a certain mass or volume of proppant, can be determined by Unified Fracture Design (UFD) method. When solving the optimal propped fracture length and width, the volume and permeability of the propped fracture should be determined first. However, they vary according to the proppant concentration in the fracture and cannot be obtained in advance. This paper proposes an iterative method to obtain the volume and permeability of propped fractures according to a desired proppant concentration. By introducing the desired proppant concentration, this paper proposes a rapid semi-analytical fracture propagation model, which can optimize fracture treatment parameters such as pad fluid volume, injection rate, fluid rheological parameters, and proppant pumping schedule. This is achieved via an interval search method so as to satisfy the optimal fracture conductivity and dimensions. Case study validation is conducted to demonstrate that this method can obtain optimal solutions under various constraints in order to meet different treatment conditions.
On the Effect of a Rail Pressure Error State Observer in Reducing Fuel Injection Cycle-to-Cycle Variation in an Opposed-Piston Compression Ignition Engine
Authors: Lu Yi , Zuo Zhe , Zhang Zhenyu , Zhao Changlu , Zhang Fujun
Published: July 2018

The fuel injection cycle-to-cycle variation characteristic in an opposed-piston compression ignition engine was investigated experimentally. Based on the optimal Proportion Integration Differentiation (PID) method, a new control method was proposed by utilizing a rail pressure error state observer (OBS) before feedback. Compared with the conventional filtering treatment method, the OBS method was developed to simultaneously account for the flow mass changing and the dynamics of a common rail system, rather than representing the rail pressure state as an average value over a period time. The OBS method was subsequently implemented in the control system to investigate the injection pressure oscillation characteristic and cycle-to-cycle variation of injected fuel quantity. The results show that the present OBS method substantially reduces the injection pressure oscillation, improves response characteristics of the control system, and produces qualitatively satisfactory fuel injection cycle-to-cycle variation in the opposed-piston compression ignition (OPCI) engine.
Core Structure and Electromagnetic Field Evaluation in WPT Systems for Charging Electric Vehicles
Authors: Elnail Kamal Eldin Idris , Huang Xueliang , Xiao Chen , Tan Linlin , Haozhe Xu
Published: July 2018

The electromagnetic field (EMF) in a wireless power transfer (WPT) system needs to couple inductively between the primary and the secondary coils through a large air gap, thus giving the system a loosely coupled characteristic. Therefore, magnetically permeable material must be employed to improve the coupling and reduce leakage magnetic flux. However, adding an iron core increases the weight and introduces core loss as a new factor. In this paper, a WPT system model using a lumped circuit model is introduced. Moreover, the relationship between the relative permeability and the coupling coefficient in addition to the core amount (core thickness) and core loss are discussed. Three cores structure named: pot, slotted, and shaped bars cores are investigated using finite element method (FEM) software. Inspired by the investigation results, a new core structure using optimum shaped bars is proposed, the EMF level for reducing core loss in high-power transfer systems and in order to mitigate the EMF exposure to humans is intensively evaluated. The proposed core succeeded in reducing EMF and core loss by about 44% and 30%, respectively. The FEM software and physical prototype were used to validate the proposed optimum core structure. Results showed that 3.5 kW power transferred through a 20 cm air gap with 96% system efficiency(coil–coil).
Late Spring Frost in Mediterranean Beech Forests: Extended Crown Dieback and Short-Term Effects on Moth Communities
Authors: Greco Silvia , Infusino Marco , De Donato Carlo , Coluzzi Rosa , Imbrenda Vito , Lanfredi Maria , Simoniello Tiziana , Scalercio Stefano
Published: July 2018

The magnitude and frequency of Extreme Weather Events (EWEs) are increasing, causing changes in species distribution. We assessed the short-term effects of a late spring frost on beech forests, using satellite images to identify damaged forests and changes in v-egetation phenology, as well as to support the analyses on associated moth communities. The EWE caused crown dieback above 1400 m of altitude, recovered only after several weeks. Nine stands for moth sampling, settled in impacted and non-impacted forests, allowed us to study changes in moth communities and in the wingspan of the most impacted species. The EWE modified community structures, reducing the abundance of beech-feeder species, but leaving species richness unaltered. Operophtera fagata and Epirrita christyi, dominant before the EWE, lost 93% and 89% of their population, respectively. We found a general increase in the average wingspan for these species, caused by the loss of small specimens in most impacted forests, suggesting a re-colonization from non-impacted forests. According to our results, populations of some species could be more resilient than others after an EWE due to their different dispersal ability. Forest ecosystems appear to be dynamic entities able to cope with extreme weather events but, likely, only if they continue to occur in the future at the current rate.
Personalised and Coordinated Demand-Responsive Feeder Transit Service Design: A Genetic Algorithms Approach
Authors: Sun Bo , Wei Ming , Yang Chunfeng , Xu Zhihuo , Wang Han
Published: July 2018

The purpose of this work is to create an efficient optimization framework for demand-responsive feeder transit services to assign vehicles to cover all pickup locations to transport passengers to a rail station. The proposed methodology features passengers placing a personalized travel order involving the subway schedule chosen by passengers and windows of service time, etc. Moreover, synchronous transfer between the shuttle and feeder bus is fully accounted for in the problem. A mixed-integer linear programming model is formulated to minimize the total travel time for all passengers, which consists of ride-time for vehicles from the pickup locations to the rail station and wait-time for passengers taking the subway beforehand. Different from conventional methods, the proposed model benefits from using a real distribution of passenger demand aggregated from cellular data and travel time or the distance matrix obtained from an open GIS tool. A distributed genetic algorithm is further designed to obtain meta-optimal solutions in a reasonable amount of time. When applied to design a feeder bus system in Nanjing City, China, case study results reveal that the total travel time of the proposed model was reduced by 2.46% compared to the traditional model. Sensitivity analyses were also further performed to investigate the impact of the number of vehicles on the output. Finally, the difference in results of Cplex, standard GA, and the proposed algorithm were compared to prove the validity of the algorithm.
Climate Change Impacts on Disaster and Emergency Medicine Focusing on Mitigation Disruptive Effects: an International Perspective
Authors: Ghazali Daniel Aiham , Guericolas Maximilien , Thys Frédéric , Sarasin François , Arcos González Pedro , Casalino Enrique
Published: July 2018

In recent decades, climate change has been responsible for an increase in the average temperature of the troposphere and of the oceans, with consequences on the frequency and intensity of many extreme weather phenomena. Climate change’s effects on natural disasters can be expected to induce a rise in humanitarian crises. In addition, it will surely impact the population’s long-term general health, especially among the most fragile. There are foreseeable health risks that both ambulatory care organizations and hospitals will face as global temperatures rise. These risks include the geographic redistribution of infectious (particularly zoonotic) diseases, an increase in cardiac and respiratory illnesses, as well as a host of other health hazards. Some of these risks have been detailed for most developed countries as well as for some developing countries. Using these existing risk assessments as a template, organizational innovations as well as implementation strategies should be proposed to mitigate the disruptive effects of these health risks on emergency departments and by extension, reduce the negative impact of climate change on the populations they serve.
Conditions and Dynamics That Impact Maternal Health Literacy among High Risk Prenatal-Interconceptional Women
Authors: Thomas Suzanne D. , Mobley Sandra C. , Hudgins Jodi L. , Sutherland Donald E. , Inglett Sandra B. , Ange Brittany L.
Published: July 2018

The purpose of the study was to describe conditions and dynamics in the lives of high-risk, low-income, Southern United States prenatal-interconceptional women (n = 37) in a home visiting program that promoted maternal health literacy progression. In the Life Course Health Development (LCHD) Model, conditions were risk and protective factors that impacted health. Dynamics drove the complex, epigenetic relationships between risk and protective factors. Maternal health literacy promotion helped participants address conditions and dynamics to create positive life changes. This research was a retrospective, mixed methods study of women’s service records documenting care from prenatal admission to 24 months post-delivery. The Life Skills Progression Instrument (LSP) was scored to measure maternal health literacy progression. Ethnographic content analysis of visit notes triangulated with quantitative data enabled specificity of critical data elements. Subsequently, a complementary focus group was conducted with the Registered Nurse Case Managers (RNCM). Severe social conditions included devastating poverty, low educational achievement, transient housing, unstable relationships, incarceration, lack of continuous health insurance, and shortage of health care providers. Dynamics included severe psycho-social stressors, domestic violence, lack of employment, low income, low self-esteem and self-expectations, and social/family restraints upon women’s intended positive changes. An important protective factor was the consistent, stable, evidence-informed relationship with the RNCM. Findings from the focus group discussion supported content analysis results.
Application Options of the Sustainable Child Development Index (SCDI)—Assessing the Status of Sustainable Development and Establishing Social Impact Pathways
Authors: Chang Ya-Ju , Lehmann Annekatrin , Winter Lisa , Finkbeiner Matthias
Published: July 2018

The needs of children and their vulnerability to diseases, violence and poverty are different from those of adults. The Sustainable Child Development Index (SCDI) was thus developed in previous work to evaluate the status of sustainable development for countries with a focus on children and triple-bottom-line thinking. This study proposes application options to put the SCDI into practice. The SCDI can be performed similarly to existing development indices, for comparing and tracing the performance of sustainable development on different geographic levels and between population groups. In addition, the SCDI can be integrated into existing social sustainability assessment approaches (e.g., Social Life Cycle Assessment and Social Organizational Life Cycle Assessment) and databases (e.g., The Social Hotspots Database) to take children into account and enhance impact assessment of social sustainability assessment approaches. As an exemplification, this study demonstrates the application of the SCDI framework to support the development of social impact pathways. Due to the importance of tertiary education in reducing poverty, a preliminary social impact pathway addressing completion of tertiary education was established. By putting the SCDI into practice, the SCDI can support decision making in child as well as sustainable development policies.
Measuring Selection Diversity of Emergency Medical Service for Metro Stations: A Case Study in Beijing
Authors: Zhang Zhe , Jia Limin , Qin Yong
Published: July 2018

It is important for station managers and emergency medical service (EMS) managers to understand the available ambulance stations for each metro station. EMS managers can make use of this information to reallocate EMS resources to improve the performance of EMS system. Station managers can pay attention to the safety management of metro stations with fewer medical rescue support. This paper aims to develop a selection diversity index to address two questions: “How many available ambulance stations are available or can serve the rescue of metro stations in emergency?” and “Which ambulance stations are most vulnerable?”. To implement this measure in practice, definition of available ambulance stations for rescue of metro stations is described based on the response time threshold. The selection diversity is proposed to measure the preparability of medical rescue service for metro stations. To show proof of concept, a real-world case is presented to demonstrate the feasibility of the selection diversity index.
Catalpol Inhibits Ischemia-Induced Premyelinating Oligodendrocyte Damage through Regulation of Intercellular Calcium Homeostasis via Na+/Ca2+ Exchanger 3
Authors: Cai Qiyan , Ma Teng , Tian Yanping , Li Chengren , Li Hongli
Published: July 2018

The heightened vulnerability of premyelinating oligodendrocytes (PreOLs) in response to hypoxia–ischemia may contribute to perinatal white matter injury and subsequent neurobehavioral dysfunction. Intracellular Ca2+ overload is considered a crucial mechanism predisposing PreOLs to ischemic injury. We previously reported that catalpol, an iridoid glycoside extracted from Rehmannia root, inhibits intracellular Ca2+ overload of PreOLs in an in vitro ischemia model. However, the exact underlying mechanisms remain elusive. In the present study, we aimed to investigate the protective effects of catalpol on PreOLs and to explore the underlying mechanisms involved in the modulation of intracellular Ca2+ homeostasis. Postnatal day 2 (P2) Sprague-Dawley (SD) rats subjected to bilateral common carotid artery ligation followed by exposure to 8% oxygen for 10 min were used as a rat model of neonatal hypoxia–ischemia. We found that catalpol significantly improved behavioral functions and prevented PreOL loss and myelination deficit after hypoxia–ischemia. Our in vitro studies also confirmed the direct effects of catalpol on oxygen-glucose deprivation (OGD)-induced cell death and arrested maturation of PreOLs. Moreover, we demonstrated that catalpol significantly inhibited intracellular Ca2+ overload and promoted the expression of Na+/Ca2+ exchanger 3 (NCX3). Finally, we found that catalpol significantly reduced mitochondrial damage and subsequent extracellular signal-regulated kinase 1/2 (ERK1/2) and poly-ADP-ribose polymerase-1 (PARP-1) activation. Treatment with NCX3-preferring inhibitor 2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea (KB-R7943) significantly reversed the protective effects of catalpol on PreOLs under OGD. Overall, our data suggest that catalpol protects PreOLs from ischemic injury through regulation of intercellular Ca2+ homeostasis via upregulation of NCX3 activity.
Importance of Full-Collapse Vesicle Exocytosis for Synaptic Fatigue-Resistance at Rat Fast and Slow Muscle Neuromuscular Junctions
Authors: Rudling Jane E. , Drever Benjamin D. , Reid Brian , Bewick Guy S.
Published: July 2018

Neurotransmitter release during trains of activity usually involves two vesicle pools (readily releasable pool, or RRP, and reserve pool, or RP) and two exocytosis mechanisms (“full-collapse” and “kiss-and-run”). However, synaptic terminals are adapted to differing patterns of use and the relationship of these factors to enabling terminals to adapt to differing transmitter release demands is not clear. We have therefore tested their contribution to a terminal’s ability to maintain release, or synaptic fatiguability in motor terminals innervating fast-twitch (fatiguable), and postural slow-twitch (fatigue-resistant) muscles. We used electrophysiological recording of neurotransmission and fluorescent dye markers of vesicle recycling to compare the effects of kinase inhibitors of varying myosin light chain kinase (MLCK) selectivity (staurosporine, wortmannin, LY294002 & ML-9) on vesicle pools, exocytosis mechanisms, and sustained neurotransmitter release, using postural-type activity train (20 Hz for 10 min) in these muscles. In both muscles, a small, rapidly depleted vesicle pool (the RRP) was inhibitor insensitive, continuing to release FM1-43, which is a marker of full-collapse exocytosis. MLCK-inhibiting kinases blocked all remaining FM1-43 loss from labelled vesicles. However, FM2-10 release only slowed, indicating continuing kiss-and-run exocytosis. Despite this, kinase inhibitors did not affect transmitter release fatiguability under normal conditions. However, augmenting release in high Ca2+ entirely blocked the synaptic fatigue-resistance of terminals in slow-twitch muscles. Thus, full-collapse exocytosis from most vesicles (the RP) is not essential for maintaining release during a single prolonged train. However, it becomes critical in fatigue-resistant terminals during high vesicle demand.
Therapeutic Opportunities of Targeting Histone Deacetylase Isoforms to Eradicate Cancer Stem Cells
Authors: Lin Peng-Chan , Hsieh Hao-Yu , Chu Po-Chen , Chen Ching S.
Published: July 2018

Cancer stem cells (CSCs), or tumor-initiating cells, are a small subset of cancer cells with the capacity for self-renewal and differentiation, which have been shown to drive tumor initiation, progression, and metastasis in many types of cancer. Moreover, therapeutic regimens, such as cisplatin and radiation were reported to induce the enrichment of CSCs, thereby conferring chemoresistance on cancer cells. Therefore, therapeutic targeting of CSCs represents a clinical challenge that needs to be addressed to improve patient outcome. In this context, the effectiveness of pan or class-I histone deacetylase (HDAC) inhibitors in suppressing the CSC population is especially noteworthy in light of the new paradigm of combination therapy. Evidence suggests that this anti-CSC activity is associated with the ability of HDAC inhibitors to target multiple signaling pathways at different molecular levels. Beyond chromatin remodeling via histone acetylation, HDAC inhibitors can also block key signaling pathways pertinent to CSC maintenance. Especially noteworthy is the ability of different HDAC isoforms to regulate the protein stability and/or activity of a series of epithelial-mesenchymal transition (EMT)-inducing transcription factors, including HIF-1α, Stat3, Notch1, β-catenin, NF-κB, and c-Jun, each of which plays a critical role in regulating CSCs. From the translational perspective, these mechanistic links constitute a rationale to develop isoform-selective HDAC inhibitors as anti-CSC agents. Thus, this review aims to provide an overview on the roles of HDAC isoforms in maintaining CSC homeostasis via distinct signaling pathways independent of histone acetylation.
Serum miRNAs Predicting Sustained HBs Antigen Reduction 48 Weeks after Pegylated Interferon Therapy in HBe Antigen-Negative Patients
Authors: Fujita Koji , Mimura Shima , Iwama Hisakazu , Nakahara Mai , Oura Kyoko , Tadokoro Tomoko , Nomura Takako , Tani Joji , Yoneyama Hirohito , Morishita Asahiro , Oryu Makoto , Himoto Takashi , Nishitsuji Hironori , Shimotohno Kunitada , Omata Masao , Masaki Tsutomu
Published: July 2018

The therapeutic goal for hepatitis B virus (HBV) infection is HBs antigen (HBsAg) seroclearance, which is achieved through 48-week pegylated interferon (Peg-IFN) therapy. This study aimed to identify predictive biomarkers for sustained HBsAg reduction by analyzing serum microRNAs. Twenty-two consecutive chronic HBV infection patients negative for HBe antigen (HBeAg) with HBV-DNA levels <5 log copies/mL, alanine aminotransferase (ALT) <100 U/L, and compensated liver functions, were enrolled. The patients were subcutaneously injected with Peg-IFNα-2a weekly for 48 weeks (treatment period), followed by the 48-week observation period. HBsAg 1-log drop relative to baseline levels recorded at the end of the observation period was considered effective. Sera were obtained at weeks 0 and 24 during the treatment period analyzed for microRNAs. The microRNA (miRNA) antiviral activity was evaluated in vitro using Huh7/sodium taurocholate cotransporting polypeptide (NTCP) cells. As a result, six patients achieved the HBsAg 1-log drop after the observation periods. Comparison of serum microRNA levels demonstrated that high miR-6126 levels at week 24 predicted HBsAg 1-log drop. Furthermore, miR-6126 reduced HBsAg in culture medium supernatants and intracellular HBV-DNA quantities in Huh7/NTCP cells. In conclusion, high serum miR-6126 levels during Peg-IFN therapy predicted the HBsAg 1-log drop 48 weeks after the completion of therapy. In vitro assays revealed that miR-6126 was able to suppress HBsAg production and HBV replication.
Cecropin A Modulates Tight Junction-Related Protein Expression and Enhances the Barrier Function of Porcine Intestinal Epithelial Cells by Suppressing the MEK/ERK Pathway
Authors: Zhai Zhenya , Ni Xiaojun , Jin Chenglong , Ren Wenkai , Li Jie , Deng Jinping , Deng Baichuan , Yin Yulong
Published: July 2018

Inflammatory bowel disease (IBD) in humans and animals is associated with bacterial infection and intestinal barrier dysfunction. Cecropin A, an antimicrobial peptide, has antibacterial activity against pathogenic bacteria. However, the effect of cecropin A on intestinal barrier function and its related mechanisms is still unclear. Here, we used porcine jejunum epithelial cells (IPEC-J2) as a model to investigate the effect and mechanism of cecropin A on intestinal barrier function. We found that cecropin A reduced Escherichia coli (E. coli) adherence to IPEC-J2 cells and downregulated mRNA expression of tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), and interleukin-8 (IL-8). Furthermore, cecropin A elevated the transepithelial electrical resistance (TER) value while reducing the paracellular permeability of the IPEC-J2 cell monolayer barrier. Finally, by using Western blotting, immunofluorescence and pathway-specific antagonists, we demonstrated that cecropin A increased ZO-1, claudin-1 and occludin protein expression and regulated membrane distribution and F-actin polymerization by increasing CDX2 expression. We conclude that cecropin A enhances porcine intestinal epithelial cell barrier function by downregulating the mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway. We suggest that cecropin A has the potential to replace antibiotics in the treatment of IBD due to its antibacterial activity on gram-negative bacteria and its enhancement effect on intestinal barrier function.
Continued Susceptibility of the wMel Wolbachia Infection in Aedes aegypti to Heat Stress Following Field Deployment and Selection
Authors: Ross Perran , Hoffmann Ary
Published: July 2018

Aedes aegypti mosquitoes infected with the wMel strain of Wolbachia are being deployed to control the spread of arboviruses around the world through blockage of viral transmission. Blockage by Wolbachia in some scenarios may be affected by the susceptibility of wMel to cyclical heat stress during mosquito larval development. We therefore evaluated the potential to generate a heat-resistant strain of wMel in Ae. aegypti through artificial laboratory selection and through exposure to field temperatures across multiple generations. To generate an artificially selected strain, wMel-infected females reared under cyclical heat stress were crossed to wMel-infected males reared at 26 °C. The low proportion of larvae that hatched founded the next generation, and this process was repeated for eight generations. The wMel heat-selected strain (wMel-HS) was similar to wMel (unselected) in its ability to induce cytoplasmic incompatibility and restore compatibility when larvae were reared under cyclical heat stress, but wMel-HS adults exhibited reduced Wolbachia densities at 26 °C. To investigate the effects of field exposure, we compared the response of wMel-infected Ae. aegypti collected from Cairns, Australia where the infection has been established for seven years, to a wMel-infected population maintained in the laboratory for approximately 60 generations. Field and laboratory strains of wMel did not differ in their response to cyclical heat stress or in their phenotypic effects at 26 °C. The capacity for the wMel infection in Ae. aegypti to adapt to high temperatures therefore appears limited, and alternative strains may need to be considered for deployment in environments where high temperatures are regularly experienced in mosquito breeding sites.
ApoB-100 Lipoprotein Complex Formation with Intima Proteoglycans as a Cause of Atherosclerosis and Its Possible Ex Vivo Evaluation as a Disease Biomarker
Authors: Hurt-Camejo Eva , Camejo Germán
Published: July 2018

Experimental and clinical data indicate that the initiation and progress of atherosclerosis and its clinical manifestations are first caused by circulating apoB-100 lipoproteins that enter and are retained in the arterial intima. Extracellular sulfated proteoglycans (PGs) of the intima are the retention agents. The PGs also initiate physical and biochemical lipoprotein degradation with the production of bioactive, lipid products that trigger an inflammatory response that leads to atherosclerosis. There are many simple methods for measuring abnormalities of circulating lipoproteins and their relation to atherosclerotic cardiovascular disease (ACVD). However, limited research aims to evaluate procedures that could report quantitatively about the contribution of the interaction of apoB-100 lipoprotein-arterial intima PGs to clinical manifestation of ACVD. In the present review we discuss observations indicating that simple ex vivo evaluation of the affinity of apoB-100 lipoproteins for arterial PGs and glycosaminoglycans (GAGs) can give an indication of its association with clinical manifestations of atherosclerosis. In addition, we discuss molecular and cellular aspects of the apoB-100 lipoproteins association with arterial PGs that are related to atherogenesis and that support the experimental framework behind the current “Response-to-Retention” hypothesis of atherosclerosis.
Projected 21st Century Coastal Flooding in the Southern California Bight. Part 2: Tools for Assessing Climate Change-Driven Coastal Hazards and Socio-Economic Impacts
Authors: Erikson Li , Barnard Patrick , O’Neill Andrea , Wood Nathan , Jones Jeanne , Finzi Hart Juliette , Vitousek Sean , Limber Patrick , Hayden Maya , Fitzgibbon Michael , Lovering Jessica , Foxgrover Amy
Published: July 2018

This paper is the second of two that describes the Coastal Storm Modeling System (CoSMoS) approach for quantifying physical hazards and socio-economic hazard exposure in coastal zones affected by sea-level rise and changing coastal storms. The modelling approach, presented in Part 1, downscales atmospheric global-scale projections to local scale coastal flood impacts by deterministically computing the combined hazards of sea-level rise, waves, storm surges, astronomic tides, fluvial discharges, and changes in shoreline positions. The method is demonstrated through an application to Southern California, United States, where the shoreline is a mix of bluffs, beaches, highly managed coastal communities, and infrastructure of high economic value. Results show that inclusion of 100-year projected coastal storms will increase flooding by 9–350% (an additional average 53.0 ± 16.0 km2) in addition to a 25–500 cm sea-level rise. The greater flooding extents translate to a 55–110% increase in residential impact and a 40–90% increase in building replacement costs. To communicate hazards and ranges in socio-economic exposures to these hazards, a set of tools were collaboratively designed and tested with stakeholders and policy makers; these tools consist of two web-based mapping and analytic applications as well as virtual reality visualizations. To reach a larger audience and enhance usability of the data, outreach and engagement included workshop-style trainings for targeted end-users and innovative applications of the virtual reality visualizations.
High-Temperature Molecular Beam Epitaxy of Hexagonal Boron Nitride with High Active Nitrogen Fluxes
Authors: Cheng Tin S. , Summerfield Alex , Mellor Christopher J. , Khlobystov Andrei N. , Eaves Laurence , Foxon C. Thomas , Beton Peter H. , Novikov Sergei V.
Published: July 2018

Hexagonal boron nitride (hBN) has attracted a great deal of attention as a key component in van der Waals (vdW) heterostructures, and as a wide band gap material for deep-ultraviolet devices. We have recently demonstrated plasma-assisted molecular beam epitaxy (PA-MBE) of hBN layers on substrates of highly oriented pyrolytic graphite at high substrate temperatures of ~1400 °C. The current paper will present data on the high-temperature PA-MBE growth of hBN layers using a high-efficiency radio-frequency (RF) nitrogen plasma source. Despite more than a three-fold increase in nitrogen flux with this new source, we saw no significant increase in the growth rates of the hBN layers, indicating that the growth rate of hBN layers is controlled by the boron arrival rate. The hBN thickness increases to 90 nm with decrease in the growth temperature to 1080 °C. However, the decrease in the MBE temperature led to a deterioration in the optical properties of the hBN. The optical absorption data indicates that an increase in the active nitrogen flux during the PA-MBE process improves the optical properties of hBN and suppresses defect related optical absorption in the energy range 5.0–5.5 eV.
A Novel Method of Synthesizing Graphene for Electronic Device Applications
Authors: Galvão Nierlly , Vasconcelos Getúlio , Pessoa Rodrigo , Machado João , Guerino Marciel , Fraga Mariana , Rodrigues Bruno , Camus Julien , Djouadi Abdou , Maciel Homero
Published: July 2018

This article reports a novel and efficient method to synthesize graphene using a thermal decomposition process. In this method, silicon carbide (SiC) thin films grown on Si(100) wafers with an AlN buffer layer were used as substrates. CO2 laser beam heating, without vacuum or controlled atmosphere, was applied for SiC thermal decomposition. The physical, chemical, morphological, and electrical properties of the laser-produced graphene were investigated for different laser energy densities. The results demonstrate that graphene was produced in the form of small islands with quality, density, and properties depending on the applied laser energy density. Furthermore, the produced graphene exhibited a sheet resistance characteristic similar to graphene grown on mono-crystalline SiC wafers, which indicates its potential for electronic device applications.
Analysis of the Secondary Phases Formed by Corrosion of U3Si2-Al Research Reactor Fuel Elements in the Presence of Chloride Rich Brines
Authors: Neumann Andreas , Klinkenberg Martina , Curtius Hildegard
Published: July 2018

Corrosion experiments with non-irradiated U3Si2-Al research reactor fuel samples were carried out in synthetic MgCl2-rich brine to identify and quantify the secondary phases because depending on their composition and on their amount, such compounds can act as a sink for the radionuclide release in final repositories. Within the experimental period of 100 days at 90 °C and anoxic conditions the U3Si2-Al fuel sample was completely disintegrated. The obtained solids were subdivided into different grain size fractions and non-ambient X-ray diffraction (XRD) was applied for their qualitative and quantitative phase analysis. The secondary phases consist of lesukite (aluminum chloro hydrate) and layered double hydroxides (LDH) with varying chemical compositions. Furthermore, iron, residues of non-corroded nuclear fuel (U3Si2), iron oxy hydroxides and chlorides were also observed. In addition to high amorphous contents (>45 wt %) hosting the uranium, the quantitative phase analysis showed, that LDH compounds and lesukite were the major crystalline phases. Scanning electron microscopy (SEM) and energy dispersive -Xray spectroscopy (EDS) confirmed the results of the XRD analysis. Elemental analysis revealed that U and Al were concentrated in the solids. However, most of the iron, added as Fe(II) aqueous species, remained in solution.
Impact of Strain and Morphology on Magnetic Properties of Fe3O4/NiO Bilayers Grown on Nb:SrTiO3(001) and MgO(001)
Authors: Kuschel Olga , Pathé Nico , Schemme Tobias , Ruwisch Kevin , Rodewald Jari , Buss Ralph , Bertram Florian , Kuschel Timo , Kuepper Karsten , Wollschläger Joachim
Published: July 2018

We present a comparative study of the morphology and structural as well as magnetic properties of crystalline Fe3O4/NiO bilayers grown on both MgO(001) and SrTiO3(001) substrates by reactive molecular beam epitaxy. These structures were investigated by means of X-ray photoelectron spectroscopy, low-energy electron diffraction, X-ray reflectivity and diffraction, as well as vibrating sample magnetometry. While the lattice mismatch of NiO grown on MgO(001) was only 0.8%, it was exposed to a lateral lattice mismatch of −6.9% if grown on SrTiO3. In the case of Fe3O4, the misfit strain on MgO(001) and SrTiO3(001) amounted to 0.3% and −7.5%, respectively. To clarify the relaxation process of the bilayer system, the film thicknesses of the magnetite and nickel oxide films were varied between 5 and 20 nm. While NiO films were well ordered on both substrates, Fe3O4 films grown on NiO/SrTiO3 exhibited a higher surface roughness as well as lower structural ordering compared to films grown on NiO/MgO. Further, NiO films grew pseudomorphic in the investigated thickness range on MgO substrates without any indication of relaxation, whereas on SrTiO3 the NiO films showed strong strain relaxation. Fe3O4 films also exhibited strong relaxation, even for films of 5 nm thickness on both NiO/MgO and NiO/SrTiO3. The magnetite layers on both substrates showed a fourfold magnetic in-plane anisotropy with magnetic easy axes pointing in 100 directions. The coercive field was strongly enhanced for magnetite grown on NiO/SrTiO3 due to the higher density of structural defects, compared to magnetite grown on NiO/MgO.
Matrix metalloproteinase-3 gene polymorphism and dilatative pathology of ascending thoracic aorta
Authors: Lesauskaitė Vaiva , Šinkūnaitė Giedrė , Benetis Rimantas , Grabauskas Vilius , Vaškelytė Jolanta , Smalinskienė Alina , Šimonytė Sandrita , Jarienė Giedrė , Tatarūnas Vacis , Klumbienė Jūratė , Petkevičienė Janina , Kinduris Šarūnas , Giedraitis Saulius , Sakalauskas Juozas , Bolys Ramūnas , Širvinskas Edmundas , Lenkutis Tadas , Pangonytė Dalia
Published: July 2018

Matrix metalloproteinase-3 (MMP-3) degrades extracellular matrix and may lead to development of dilatative pathology of ascending thoracic aorta. Expression of MMP-3 depends upon the 5A/6A polymorphism in the promoter region. An increased number of 5A alleles leads to high expression of MMP-3. Thus, objective of the study was to determine whether the 5A/6A polymorphism in the promoter region of MMP-3 gene is associated with the development of dilatative pathology of ascending thoracic aorta. We studied 76 patients (age ranged from 31 to 81 years; median age, 64 years) who underwent aortic reconstruction surgery due to dilatative pathology of ascending thoracic aorta and a random sample of the population (n=604) aged 25–64 years, all from Lithuania. DNA was analyzed by using real-time polymerase chain reaction to genotype polymorphism 5A/6A at a position – 1171 of the MMP3 gene promoter. The prevalence of MMP-3 genotypes was similar in the group of dilatative pathology of ascending thoracic aorta and random sample of population. The frequency of 5A allele did not differ significantly between both groups and was 0.506 and 0.514, respectively. Male carriers of 5A/5A genotype were significantly younger compared with those with the 6A/6A genotype. In conclusion, the frequency of MMP-3 promoter 5A/6A genotypes did not differ between the group of patients with dilatative pathology of ascending thoracic aorta and the random sample of population, but the males with dilatative pathology of ascending thoracic aorta and 5A/5A genotype required aortic reconstruction surgery at the younger age than the males carrying 6A/ 6A genotype in the MMP-3 promoter region.
Plant-Based Cannabinoids for the Treatment of Chronic Neuropathic Pain
Authors: Casey Sherelle L. , Vaughan Christopher W.
Published: July 2018

Chronic neuropathic pain is a prevalent condition that places a heavy burden on individuals and the healthcare system. Current medications have limitations and new approaches are needed, particularly given the current opioid crisis. There is some clinical evidence that the plant Cannabis sativa produces relief from neuropathic pain. However, current meta-analyses suggest that this efficacy is limited and there are problems with side effects. Most of this clinical research has examined whole cannabis, the psychoactive phytocannabinoid 9-tetrahydrocannabinol (THC), and nabiximols, which are a mixture of THC and the non-psychoactive phytocannabinoid cannabidiol. In the past, there has been little evidence based, preclinical animal research to guide clinical studies on phytocannabinoids. Recent animal studies indicate that while THC and high dose nabiximols are effective in animal neuropathic pain models, significant pain relief is only achieved at doses that produce substantial side effects. By contrast, cannabidiol and low dose nabiximols have moderate pain relieving efficacy, but are devoid of cannabinoid-like side effects. This animal data suggests that cannabidiol and low dose nabiximols warrant consideration for clinical studies, at least as adjuvants to current drugs. Preclinical research is also required to identify other phytocannabinoids that have therapeutic potential.
Development of Porous Coatings Enriched with Magnesium and Zinc Obtained by DC Plasma Electrolytic Oxidation
Authors: Rokosz Krzysztof , Hryniewicz Tadeusz , Gaiaschi Sofia , Chapon Patrick , Raaen Steinar , Malorny Winfried , Matýsek Dalibor , Pietrzak Kornel
Published: July 2018

Coatings with developed surface stereometry, being based on a porous system, may be obtained by plasma electrolytic oxidation, PEO (micro arc oxidation, MAO). In this paper, we present novel porous coatings, which may be used, e.g., in micromachine’s biocompatible sensors’ housing, obtained in electrolytes containing magnesium nitrate hexahydrate Mg(NO3)2·6H2O and/or zinc nitrate hexahydrate Zn(NO3)2·6H2O in concentrated phosphoric acid H3PO4 (85% w/w). Complementary techniques are used for coatings’ surface characterization, such as scanning electron microscopy (SEM), for surface imaging as well as for chemical semi-quantitative analysis via energy dispersive X-ray spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS), glow discharge optical emission spectroscopy (GDOES), and X-ray powder diffraction (XRD). The results have shown that increasing contents of salts (here, 250 g/L Mg(NO3)2·6H2O and 250 g/L Zn(NO3)2·6H2O) in electrolyte result in increasing of Mg/P and Zn/P ratios, as well as coating thickness. It was also found that by increasing the PEO voltage, the Zn/P and Mg/P ratios increase as well. In addition, the analysis of XPS spectra revealed the existence in 10 nm top of coating magnesium (Mg2+), zinc (Zn2+), titanium (Ti4+), and phosphorus compounds (PO43−, or HPO42−, or H2PO4−, or P2O74−).
Kinematics Error Compensation for a Surface Measurement Probe on an Ultra-Precision Turning Machine
Authors: Li Duo , Jiang Xiangqian , Tong Zhen , Blunt Liam
Published: July 2018

In order to enhance the measurement availability for manufacturing applications, on-machine surface measurement (OMSM) is integrated onto the machine tools, which avoids the errors caused by re-positioning workpieces and utilizes the machine axes to extend the measuring range as well. However, due to the fact that measurement probe actuation is performed using the machine tool axes, the inherent kinematics error will inevitably induce additional deviations onto the OMSM results. This paper presents a systematic methodology of kinematics error modelling, measurement, and compensation for OMSM on an ultra-precision turning lathe. According to the measurement task, a selective kinematics error model is established with four primary error components in the sensitive measurement direction, based on multi-body theory and a homogeneous transformation matrix (HTM). In order to separate the artefact error from the measurement results, the selected error components are measured using the reversal method. The measured error value agrees well with the machine tool’s specification and a kinematics error map is generated for further compensation. To verify the effectiveness of the proposed kinematics error modelling, measurement, and compensation, an OMSM experiment of an optically flat mirror is carried out. The result indicates the OMSM is the superposition of the sample surface form error and the machine tool kinematics error. With the implementation of compensation, the accuracy of the characterized flatness error from the OMSM improves by 67%.
Comparative Analysis of the Siliceous Source and Organic Matter Enrichment Mechanism of the Upper Ordovician–Lower Silurian Shale in the Upper-Lower Yangtze Area
Authors: Zhang Kun , Li Zhuo , Jiang Shu , Jiang Zhenxue , Wen Ming , Jia Chengzao , Song Yan , Liu Weiwei , Huang Yizhou , Xie Xuelian , Liu Tianlin , Wang Pengfei , Shan Chang’an , Wu Yinghui
Published: July 2018

Organic matter is the material basis of hydrocarbon generation and the abundance of organic matter is a main factor of regional selection and evaluation in shale gas. Also the enrichment is influenced by sedimentary environments. Thus, it is important for the study on the geological factors controlling organic matter enrichment and further to provide scientific basis of regional selection and evaluation by organic matter enrichment area with analysis of the factors. In this paper, the Upper Ordovician–Lower Silurian shale from representative wells in the Upper-Lower Yangtze area is selected as the research object. The goal of this study is to quantitatively calculate the excess siliceous mineral content in shale siliceous minerals and determine the origin of excess silicon based on Al, Fe, and Mn elements; as well as to analyze the sedimentary organic matter enrichment mechanism based on the water body redox environment and bio-productivity. The results show that excess silicon from the Upper Ordovician–Lower Silurian shale in the Upper Yangtze area is biogenic and deposited in closed water bodies. On the one hand, the upper water body contains oxygen, which leads to higher bio-productivity. On the other hand, the lower water body has strong reducibility, which is conducive to sedimentary organic matter preservation. However, the excess silicon in the Upper Ordovician–Lower Silurian shale of the Lower Yangtze area is derived from hydrothermal solution. Hydrothermal activity can enhance the bottom water reducibility, and its nutrient elements can improve bio-productivity and enrich sedimentary organic matter. Therefore, the organic matter enrichment, which depends on the biological productivity and redox conditions, is controlled by the water closure in the Upper Yangtze and hydrothermal activities in the Lower Yangtze respectively. It led to a conclusion that in the process of regional selection and evaluation of shale gas in the Late Ordovician–Early Silurian, it is favorable in the area of relatively strong closure, which is the center of cratonic depression, in the Upper Yangtze and in the hydrotherm-active area, which is the plate connection of the Lower Yangtze and the Cathaysian, in the Lower Yangtze.