bluuebunny/crossref_metadata_2025 huggingface dataset:
The association between epicardial adipose tissue thickness and left atrial phasic function in patients with non-valvular atrial fibrillation
Authors: Yang You , Liu Biaohu , Ji Wenyan , Ding Jing , Tao Shanqiang , Lian Feifei , Wang Deguo
Published: May 2022

AbstractPurpose: The purpose of our study was to
explore the relationship between EAT thickness and left atrial phasic
function in patient with non-valvular atrial fibrillation (NVAF).
Methods: 100 NVAF patients were enrolled, including 50 patients
with paroxysmal AF and 50 patients with persistent AF. Another 50
patients without AF in sinus rhythm were selected as the control group.
EAT thickness in front of the right ventricular free wall was measured
using transthoracic echocardiography(TTE) at end-systole, while left
atrial phasic function parameters were measured by Real-time
three-dimensional echocardiography(RT-3DE) and two-dimensional speckle
tacking imaging(2D-STI), including left atrial total emptying
fraction(LATEF), left atrial active emptying fraction(LAAEF), left
atrial passive emptying fraction(LAPEF), left atrial reservoir
strain(LASr), left atrial contraction strain(LASct) and left atrial
conduit strain(LAScd). Subsequently, we compared EAT thickness and left
atrial phasic function parameters in each group, and analyzed the
relationship between EAT thickness and left atrial phasic function
parameters. Results: Compared with control group, patients with
paroxysmal AF and persistent AF groups had sequentially greater EAT
thickness and left atrial diameter (LAD), but sequentially lower left
atrial phasic function parameters (LATEF, LAAEF, LAPEF, LASr, LASct,
LAScd) (all p<0. 001). By Pearson and Spearman Correlation
Coefficient, EAT thickness was significantly positively correlated with
LAD and negatively correlated with left atrial phasic function
parameters (all p<0. 001). Conclusions: EAT thickness
in front of the ventricular free wall measured by TTE was significantly
correlated with left atrial phasic function in patients with NVAF, which
could effectively reflect the trend of left atrial function changes,
thus providing some reference for clinical practice and early
intervention of left atrial remodeling.
Buoyant or Sinking? Tax Revenue Performance and Prospects in Developing Asia
Authors: Hill Samuel , Jinjarak Yothin , Park Donghyun
Published: May 2022

This paper examines tax revenue mobilization in developing Asia before the coronavirus disease (COVID-19) pandemic and in 2020. Analysis suggests that short- and long-run tax buoyancy in developing Asia were close to one before COVID-19, indicating fiscal sustainability. The study estimates that in 2020 the pandemic caused these economies to lose average excess tax revenue equal to half a percentage point of 2019 GDP. It also finds that tax-to-GDP ratios are projected to improve toward 2030 in a majority of developing Asian economies, other things held constant.
The Biofield Energy Treatment and its Effect on the Relative Oral Bioavailability of Lovastatin Hydroxy Acid in Rats after a Single Oral Dose of Lovastatin
Authors: S Jana
Published: May 2022

Lovastatin is a lipid-lowering drug used to reduce the risk of cardiovascular disease. Lovastatin shows poor oral bioavailability (<5%) because of its low water solubility and short half-life. Therefore, the present study was performed to determine the effects of the Trivedi Effect ® - Consciousness Energy Treatment (Blessing) on lovastatin and rats through the measurement of plasma lovastatin hydroxy acid concentrations after the oral administration of lovastatin in rats. The test item, lovastatin was divided into two parts. One part was denoted as the control, while the other part was defined as the Biofield Energy Treated sample, which received the Biofield Energy Treatment for about 3 minutes by renowned Biofield Energy Healer, Dahryn Trivedi. Additionally, one group of animals also received Biofield Energy Treatment under similar conditions. The Biofield Energy Healer who was located in the USA, while the test samples and animals were located in the research laboratory in India. Lovastatin oral formulations were administrated by oral gavage at a dose of 50 mg/kg in groups viz . G1 (untreated lovastatin), G2 (Biofield Treated lovastatin), and G3 (Biofield Treated animals received untreated lovastatin) group. The majority of lovastatin was rapidly converted to its metabolite, i.e. , lovastatin hydroxy acid following the oral administration. The pharmacokinetic parameter, the C max of lovastatin hydroxy acid was significantly altered by 155.76% and -24.82% in G2 and G3, respectively compared to G1. The T max of lovastatin hydroxy acid was significantly increased by 254.55% in G2 and 51.52% in G3 compared to G1. The mean residence time of lovastatin hydroxy acid was also altered in G2 (-30.46%) and G3 (3.96%), as compared to the G1. The relative oral bioavailability (Fr) of lovastatin was significantly increased by 281.87% in the group G2 and 15.71% in the group G3 compared to the G1. These data suggest that the Biofield Energy Treatment could be considered as an innovative strategy that opens new avenues to improve the bioavailability of nutraceuticals/pharmaceuticals and can also modulate the therapeutic performance of orally active molecules. The Biofield Energy Treated lovastatin could be beneficial for the treatment of cardiovascular disease, which includes heart attack, stroke, atherosclerosis, coronary revascularization, coronary death, myocardial infarction, unstable angina, peripheral artery disease, abdominal aortic aneurysm, chronic kidney disease, etc.
Association of Elevated Levels of Some Intra-Thyroidal Trace Elements with Goiter and Cancer Risk of Female Thyroid
Authors: V Zaichick
Published: May 2022

Introduction: Advancing age is known to influence the formation of adenomatous goiter and thyroid cancer. An excess or deficiency of specific TEs contents in thyroid can play an important role in goitro- and carcinogenesis of this gland. Objective: This study aimed to assess the variation with age of fifty trace element (TE) contents in normal female thyroid. Methods: Samples of the human thyroid were obtained from randomly selected autopsy specimens of 33 females (European- Caucasian) aged 3.5 to 87 years after a sudden death mainly from trauma. The mass fractions of TEs in normal female thyroids were investigated using neutron activation analysis and inductively coupled plasma mass spectrometry. Tissue samples were divided into two portions. One was used for morphological study while the other was intended for TEs analysis. Results: This work revealed that there is a statistically significant increase in Co, Cs, Fe, La, Pb, Rb, Sb, Se, Sn, Tl, and Zn mass fraction in the normal thyroid of female during a lifespan. Contents of such carcinogenic or potentially carcinogenic TEs as Co, La, Pb, Sb, Sn, and Tl in thyroid of seniors are 5-10 times higher than those in thyroid of girls or young women. Conclusions: From results of our study, a goitrogenic and carcinogenic effect of elevated Co, Cs, Fe, La, Pb, Rb, Sb, Se, Sn, Tl, and Zn levels in the thyroid of elderly females is shown to be a very likely consequence.
About Consciousness, Subtle Energies and Unification
Authors: Di Sia Paolo
Published: May 2022

In this paper we analyze the consciousness through a new structural model of energy we could call "General Gaussian Energy Group" (GGEG). By the infinite number of symmetry groups we recognize a series of new energy sources. We consider these ones as effective causes for fundamental consciousness. They would play an important role for consciousness (physical stuff with spirit stuff), explaining an individual material body system within a broader global system. The involved energy sources are SU(6), SU(12), SU(24), etc. This new structural model can be explained mathematically as follows: SU(11) ⊃ SU(6) × SU(5) × U(1); SU(23) ⊃ SU(12) × SU(11) × U(1); SU(47) ⊃ SU(24) × SU(23) × U(1), etc, bringing to the creation of various new unknown particle-like entities in wave status, directly and indirectly linked to the creation of life, consciousness and other biological phenomena. The model, called B-DS model, is giving new answers to unsolved questions of reality. It is a new set of primary elements linked to the theory of quantum entanglement. These new structure is also particularly important for clarifications about subtle energies and about the deep vacuum structure.
Stochastic machine learning modeling for the estimation of some uncertain parameters. Case study: Retardation factor in a radionuclide transport model
Authors:   Mathematics, Computer Sciences and Applications Team (ERMIA), University of AbdelMalek Essaadi, ENSA of Tangier, Morocco, El Yamani M. A. , Lazaar S. ,   Mathematics, Computer Sciences and Applications Team (ERMIA), University of AbdelMalek Essaadi, ENSA of Tangier, Morocco
Published: May 2022

In the present work, we define a stochastic model using machine learning techniques to generate random fields of some uncertain parameters. The proposed stochastic model is based on Bayesian inference and aims at reconstituting the parameters of interest and their credible intervals. The main goal of this work is to define a model that estimates the values of the uncertain parameters known only by their distribution probability functions and some observed spatial measurements. We note that this type of parameters may be associated with some mathematical models usually traduced by non-linear differential equations. In our case, we study the uncertainty of the retardation factor in a radionuclide transport model. To achieve a more realistic parameter estimation, Markov сhain Monte Carlo (MCMC) algorithms are applied. We demonstrate that the obtained results confirm the feasibility of our proposed model and lead to a new understanding of contaminants' behavior.
Pembuatan Eco Enzyme Sebagai Hand Sanitizer Dalam Upaya Pencegahan Covid-19 Bagi Warga SMPN 2 Sekampung
Authors: Nur Anisa Devi , Utami Gamilla Nuri , Nurvazly Dina Eka , Chasanah Siti Laelatul
Published: May 2022

Sejalan dengan peningkatan aktivitas manusia di rumah tangga menyebabkan semakin besarnya volume limbah yang dihasilkan. Salah satunya adalah limbah organik. Limbah organik ketika dibuang dan membusuk akan menghasilkan Karbondioksida dan Gas Metana. Hal ini adalah salah satu faktor yang memperburuk efek pemanasan global yang menjadi topik serius akhir-akhir ini. Limbah ini ternyata mempunyai banyak sekali manfaat jika diolah dengan benar, salah satunya dengan mengolahnya menjadi eco enzyme. Eco enzyme merupakan ekstrak cairan yang dihasilkan dari fermentasi sisa sayuran dan buah-buahan dengan substrat gula. Tujuan pengabdian kepada masyarakat ini yaitu mengedukasi masyarakat tentang pembuatan eco enzyme yang memiliki banyak manfaat salah satunya yaitu dapat berfungsi sebagai hand sanitizer sebagai salah satu produk anti Covid-19. Metode pelaksanaan pengabdian kepada masyarakat yang dilakukan yaitu pelatihan dan praktek pembuatan eco enzyme menjadi hand sanitizer.
Pembuatan Kompos Seresah Menggunakan Inokulum Fungi Saprotrof Di Pesantren Darul Fattah Gedung Meneng Bandar Lampung
Authors: Farisi Salman , Irawan Bambang , Suratman Suratman , Busman Hendri , Kiswandono Agung Abadi
Published: May 2022

Kompos adalah zat akhir suatu proses fermentasi tumpukan sampah/serasah tanaman termasuk bangkai binatang. Fermentasi tersebut perlu dipercepat dengan bantuan manusia. Isolat fungi saprotrof ini sangat potensial untuk dikembangkan menjadi inokulum pengomposan dalam pembuatan pupuk organik. Kompos yang diinduksi dengan inokulum fungi ini mampu menghasilkan pupuk organik dengan relatif cepat dan mengandung nutrisi tanaman yang tinggi. Prospek kebutuhan pupuk organik cukup tinggi dalam menunjang pertanian organik sehingga diperlukan penyebaran informasi IPTEK dan pelatihan kepada masyarakat tentang pembuatan pupuk organik dengan induksi inokulum fungi saprotrof. Selain itu ketersediaan seresah tanaman pekarangan melimpah dan terbebas dari residu bahan kimia. Hasil kegiatan ini memperlihatkan terjadi peningkatan pengetahuan dan pemahaman peserta pelatihan dalam pembuatan pupuk kompos dari seresah daun. Rata-rata peningkatan pengetahuan peserta pelatihan sebesar 30%.
Pembentukan Warung Unit Minyak Jelantah Bagi Ibu-Ibu PKK Di Bandar Lampung
Authors: Handayani Kusuma , Kanedi M , Setiawan Wawan Abdullah , Oktaviantimala Oktaviantimala
Published: May 2022

Minyak jelantah (mijel) atau minyak goreng bekas pakai masih sering digunakan konsumen untuk penghematan. Namun penggunaan lebih dari 3x dapat menimbulkan masalah kesehatan. Kegiatan pelatihan ini bertujuan untuk mengedukasi ibu-ibu akan bahaya penggunaan mijel secara berulang dan memberikan solusi pemanfaatan mijel dalam bentuk lain. Selain itu juga untuk sosialisasi pembentukan warung minyak jelantah yang dapat menerima sumbangan minyak jelantah agar dimanfaatkan untuk pembuatan sabun cuci skala besar. Kegiatan ini terdiri dari ceramah, diskusi, demonstrasi dan praktik langsung. Praktik dan demonstrasi dimaksudkan untuk memberikan ketrampilan menentukan formula yang tepat dalam pembuatan sabun cuci dari mijel. Peserta yang hadir 25 orang, berasal dari PKK Kelurahan yang ada di Bandar Lampung. Evaluasi kegiatan ini menunjukan peningkatan pemahaman bagi peserta dengan rerata sebesar 34% dan terbentuk 3 warung minyak jelantah di Kedaton, Way halim dan Langkapura. Pembentukan warung ini diharapkan dapat membantu mengatasi limbah mijel dari rumah tangga.
The The Impact of the Heutagogy Approach on Responsibilities for Online Learning in Statistics Courses
Authors: Ningsih Endang Mulyati , Munif Ngabdul , Sugiyono Sugiyono
Published: May 2022

This study aims to determine: (1) learning responsibilities and; (2) positive, negative and accompaniment impacts that occur after learning statistics using the heutagogy approach. This study uses an impact evaluation method with a goal free evaluation model. The population of this study was 104 students who took the Statistics course in the Odd Semester 2020. The sample was selected using a systematic technique as many as 82 students. The research data were collected from grades and assignments documents, interviews and learning responsibility questionnaires. The quality of the instrument was controlled using item validity and reliability with a halving technique. The validity of the qualitative data was controlled by means of document triangulation and interviews. The results showed: (1) the highest learning responsibility was in the learning effort, followed by discipline, independence, motivation and honesty; (2) the positive impact is felt by students in the upper group because they are more successful in learning anytime and anywhere, the negative impact is felt by the lower group because it opens up opportunities to look for examples of friends' answers. The impact of the accompaniment is that there is cooperation in the face of difficulties
Implementasi Pembelajaran Tatap Muka (PTM) Terbatas Selama Masa Pandemi Covid-19 di SMA N 1 Kubu
Authors: Pernantah Piki Setri , Rizatunnita Rizatunnita , Kusnilawati Liza , Handrianto Ciptro
Published: May 2022

This article aims to discuss the process of implementation of Limited Face-to-Face Learning (PTM) during the Covid-19 Pandemic and the obstacles faced and efforts made in the smooth implementation of limited face-to-face learning at SMA N 1 Kubu, Riau, Indonesia. The research method used is a descriptive-qualitative method with data collection techniques through observation and interview activities that do not provide treatment, manipulation or changes in the variables studied. The results of this study showed that the application of limited face-to-face learning still follows the standards of health protocols, during learning has carried out 3M, namely wearing a mask before entering the classroom, washing hands using soap and running water and entering the classroom regularly and maintaining distance. Also implement learning strategies that include practice, discussion, reflection and feedback so as to make learning work effectively.
AN EXPLORATION ON STUDENTS’ PUBLIC SPEAKING ANXIETY: STIFIn PERSPECTIVE
Authors: Rahman Hz Benni Ichsanda
Published: May 2022

The purpose of this research is to examine the level of public speaking anxiety among students based on the differences in human intelligence machine division: STIFIn (Sensing, Thinking, Intuiting, Feeling, and Insting). This study involved 51 Management students who took the English for Specific course on their semester credits. This study employs a case study that is qualitative in nature. The data was gathered using a semi-structured approach. The data collected was then processed by using two methods: statistical calculations for quantitative data related to the results of filling out 17 Public Speaking Anxiety Scale (FLAS) questionnaires by students concerning their level of anxiety when performing a public speaking and constructive analysis for qualitative data related to the results of comparing respondents' responses. The results shows that students in the Insting personality have a higher average of public speaking anxiety: 51.60. Students who are Sensing have an average anxiety level of 49.25, whereas students who are Thinking have an anxiety level of 47.50. In comparison, Intuiting students have an average anxiety level of 48.66, while Feeling students have an average anxiety level of 50.17. Consider the implications, some suggestions are discussed to overcome the challenges.
Cumhuriyetin ilanından günümüze Türkiye’de okul öncesi eğitimdeki değişimler
Authors: Deretarla Gül Ebru
Published: May 2022

Ülkemizde okul öncesi eğitimin tarihine bakıldığında “ana mektepleri, çocuk bahçesi, anaokulu, çocuk yuvası, kreş, anasınıfı” vb isimlerle yer aldığı görülmektedir. Cumhuriyetin ilk yıllarından itibaren eğitim sistemimizde okul öncesi eğitime yer verilmiştir. Günümüzde okul öncesi eğitimin çocukların hazırbulunuşluklarını artırması ve ilkokula geçişini kolaylaştırması nedeniyle daha çok çocuğun okul öncesi eğitimden yararlandığı görülmektedir. Bu derleme çalışmasında Cumhuriyetin ilanından günümüze kadar geçen sürede Türkiye’de okul öncesi eğitimin Milli Eğitim şura raporlarında nasıl yer aldığı, okul öncesi eğitim programlarının temel özellikleri ve okul öncesi eğitimdeki sayısal değişimlerin ortaya konulması amaçlanmıştır. Bu amaçla yapılan incelemelerde Milli Eğitim şuralarından 9. sunda  okul öncesi eğitimin amaç, kapsam ve kuruluşu ile ilgili düzenlenmelerin yer aldığı, 14. Milli Eğitim Şurasında okul öncesi eğitimin yaygınlaştırılması vurgulanmaktadır. Okul öncesi eğitimle 90’lı yılların sonundan itibaren okul öncesi eğitimde öğrenci, öğretmen ve derslik sayısında önemli artışlar görülmektedir. Program boyutunda okul öncesi eğitim programlarının “çocuk merkezli” ve “oyun temelli” programlara biçiminde düzenlendiği dikkat çekmektedir.
Okul öncesi öğretmen adaylarının epistemolojik inançları ile matematik öğretimi ve öğrenimine yönelik inançları
Authors: Gümüştekin Ertugay Tülin , Güven Yıldız
Published: May 2022

Araştırmanın amacı, okul öncesi eğitimdeki öğretmen adaylarının epistemolojik inançları ile matematik öğretimi, öğrenimi ve inançları arasındaki ilişkiyi belirlemek ve öğretmen adaylarının epistemolojik inançlarının, matematik öğretimi ve öğrenimine ilişkin inançlarını yordayıp yordamadığını araştırmaktır. Nicel araştırma kapsamında, ilişkisel tarama modeliyle tasarlanan araştırmanın çalışma grubu, İstanbul’daki beş üniversitenin okul öncesi eğitimi anabilim dalında öğrenim gören 248 son sınıf öğrencisidir. Araştırmada veri toplama araçları olarak “Epistemolojik İnançlar Ölçeği” ve “Matematik Öğretimi, Öğrenimi ve İnançlar Ölçeği” kullanılmıştır. Sonuçlar, okul öncesi öğretmen adaylarının epistemolojik inanç alt boyutlarından olan “öğrenme süreci- otorite/ uzman bilgisine şüphe” ve “öğrenme çabası” inanç düzeyleri artıkça matematik öğretimi ve öğrenimine ilişkin inanç düzeylerinin arttığını, öğretmen adaylarının “doğuştan/ sabit yetenek” ve “bilginin kesinliği” inanç düzeyi arttıkça, matematik öğretimi ve öğrenimine ilişkin inanç düzeylerinin azaldığını göstermiştir. Çalışma, öğretmen adaylarının “öğrenme süreci/uzman bilgisine şüphe” inancının matematik öğretimi ve öğrenimine ilişkin inançlarını pozitif olarak, “doğuştan/sabit yetenek” ve“bilginin kesinliği” inançlarını ise negatif olarak yordadığını göstermiştir.
Pedagogıcal Aspects of Famıly Functıonıng
Authors: Viskovic Ivana , LjubetiÄ‡ Maja
Published: May 2022

Various changes in the conditions of social functioning also affect family functioning. Respecting the personality and autonomy of the individual, the connection between the quality of family functioning and educational outcomes of children cannot be neglected. The pedagogical influence of the family on the individual is recognizable by the adopted value orientations and social norms, models of behaviour, learning strategies, ways of distributing power and taking responsibility; communication and ways of solving problem situations, as well as flexibility and expressiveness. Understanding family functions (economic, socio-emotional, religious, reproductive”¦) and their simultaneous impact on children, it is unjustified to interpret children's educational outcomes based on separate aspects of family functioning. Relevant research indicates that a number of latent and intervening variables are associated with children's educational outcomes, and therefore the family is accepted as a nonlinear dynamic system, so changes and children's outcomes are certain, but not easily predictable.
THE VALUE OF FORMAL EDUCATION IN THE PERSONAL DEVELOPMENT OF PRIMARY SCHOOL PUPILS
Authors:   Aurel Vlaicu University of Arad, Romania, Egerau Anca Manuela
Published: May 2022

Education has a decisive role on the personal development of the individual. It is especially important that from an early age the individual should have an effective education that will reflect on his entire life. Along with education, the internal and external factors that condition the development of the individual also play an important role. Internal factors are heredity and psychosocial and biological influences and the main external factor is the environment. A relationship of interdependence and mutual and continuous correlation is established between the internal and external factors of development. Each factor helps and determines the formation and development of the other in order to achieve the goals of education. The school offers the student the framework for development, training, socialization starting from the knowledge of the individual and age peculiarities specific to each stage of development, by designing a strategy and by carrying out a rigorous didactic approach, based on a program, planning, educational resources, methods. and didactic strategies aimed at achieving the objectives and the proposed goal. The present article shows the results of a brief research on the personal development of pupils and some elements of personality through instructive-educational activities within the frame of the formal education. The main instrument used was the questionnaire, applied to a number 73 4th grade pupils from a class from Arad County. The questions relate to the experiences of pupils in formal education and especially to the way in which they perceive the changes, events, learning and socialization that take place in these years and the way all these connect to the development of their personality through education.
THEORIZING AN INTEGRATIVE-QUALITATIVE INTENTIONAL BEHAVIOR MODEL IN ROMANIAN PRESCHOOL TEACHERS FOR SDG4 (EQUAL ACCESS TO QUALITY PRE-PRIMARY EDUCATION)
Authors:   AurelVlaicu University of Arad, Romania, Redes Adela , Rad Dana , Roman Alina Felicia , Egerau Anca Manuela , Balas Evelina
Published: May 2022

Quality education is one of the 17 Sustainable Development Goals (SDGs) set by the United Nations in 2015. SDG 4 refers to guaranteeing inclusive and equitable quality education for all, as well as fostering opportunities for lifelong learning for everyone. Equal access to high-quality pre-primary education is one of DSG4's 11 indicators, and it will be discussed further in this study. The goal of this study is to lay a theoretical foundation for the development and validation of an integrative-qualitative intentional behavior scale in Romanian early childhood education and care system. Our theoretical research will also be used to develop an integrative-qualitative intentional behavior prediction methodology that can be used to predict preschool teachers' integrative-qualitative intentional behavior in ECEC teachers and aid educational decision-makers in developing timely interventions that increase the likelihood of success. The study's major findings point to important components that might help Romanian educational decision-makers improve SDG4 outcomes.
EFFECT OF COOPERATIVE LEARNING ON PRIMARY SCHOOL PUPILS’ READING ACHIEVEMENT IN AWKA METROPOLIS
Authors:   Department of Early Child and Primary Education, Nnamdi Azikiwe University, Awka, Anambra State, AMAECHI ANIDI CHARLES
Published: May 2022

This study investigated the effect of cooperative learning on reading achievement of primary school pupils in Awka Metropolis in Awka South Local Government Area. Two research questions and two null hypotheses guided the study. The study adopted a quasi-experimental design specifically the pre-test, post-test control group design. The population comprised of 3,419 primary five pupils in Awka metropolis and 65 pupils selected from schools that use Macmillan English who participated in the study formed the sample for the study. Reading Achievement Test (RAT) with a reliability coefficient of 0.89 determined using Kuder-Richardson Formula 20 was used to collect data for the study. Pupils in the experimental group were taught reading using reciprocal peer tutoring, a type of cooperative learning considered in the study while those in the control group were taught reading using conventional method. Data collected were analyzed using mean scores for research questions and Analysis of Covariance (ANCOVA) for testing the hypotheses at 0.05 level of significance. Major findings revealed that pupils taught reading with Reciprocal Peer Tutoring (RPT) performed significantly better than those taught with conventional method did. There was no significant difference in the performance of male and female pupils taught reading with RPT. Based on the findings, it was recommended that teachers training colleges and universities should incorporate reciprocal peer tutoring in their curriculum so that prospective teachers will be acquainted with the basic skills for designing RPT instructional materials for use in their respective classrooms. Teachers should be well equipped and integrated with RPT for an effective teaching, mastery and its application in the teaching and learning processes.
Correlation between brush cytology results and histopathological examination in diagnostic evaluation of precancerous conditions and laryngeal cancer: A prospective study
Authors: Lepka Paulina , Zatoński Tomasz , Barnaś Szczepan , Lepka Piotr , Hałoń Agnieszka
Published: May 2022

Introduction

The aim of the paper was to demonstrate that brush cytology can be useful in diagnostic evaluation of precancerous states and laryngeal cancer.

Materials and Methods

Ninety-two patients were analyzed. The control group included patients with benign laryngeal lesions, while the study group was composed of patients in whom a precancerous condition or laryngeal cancer was suspected. Material for histopathological and cytological examination was collected during a laryngeal microsurgery. The authors analyzed the consistency of the results of cytological and histopathological examination in the diagnostic evaluation of precancerous conditions and laryngeal cancer.

Results

Comparing diagnoses based on cytological examination with the results of histopathological examinations, the authors observed that there was a strong and statistically significant (p<0.001) correlation between the results. The accuracy of brush cytology in the conducted study indicates that the sensitivity and specificity of the test reaches 90.09% and 93.5% with 4 false negative and 3 false positive results. Positive prediction reached 93% and negative prediction reached 91.5%.

Conclusions

Brush cytology of the larynx may be useful in screening and as an auxiliary test in diagnostic evaluation of precancerous conditions and laryngeal cancer.
Decomposition mechanisms of continuously cooled bainitic rail in the critical heat-affected zone of a flash-butt welded joints
Authors: Królicka Aleksandra , Żak Andrzej , Kuziak Roman , Radwański Krzysztof , Ambroziak Andrzej
Published: May 2022

The joining process of bainitic rails is significant in terms of their industrialization in high-speed and heavy-loaded railways. This paper demonstrates the microstructure changes in the critical zone of the welded joint, which is responsible for the greatest deterioration in mechanical properties. Extensive progress in the decomposition of the retained austenite and bainitic ferrite occurs in the low-temperature heat-affected zone (LTHAZ) of the flash-butt welded joint of low-carbon bainitic rail. The decomposition products of the retained austenite were mainly a mixture of cementite and ferrite. The cementite was mainly precipitated at the boundary of the bainitic ferrite laths, which indicates lower thermal stability of the filmy austenite. Moreover, it was found that a part of the refined blocky retained austenite was decomposed into the ferrite and nanometric cementite, while another remained in the structure. The decomposition mechanisms are rather heterogeneous with varying degrees of decomposition. A relatively high proportion of dislocations and stress fields prove the occurrence of residual stresses formed during the welding process.
Treatment of skin tumors with intratumoral interleukin 12 gene electrotransfer in the head and neck region: a first-in-human clinical trial protocol
Authors: Groselj Ales , Bosnjak Masa , Jesenko Tanja , Cemazar Maja , Markelc Bostjan , Strojan Primoz , Sersa Gregor
Published: May 2022

Background

Immune therapies are currently under intensive investigation providing in many cases excellent responses in different tumors. Other possible approach for immunotherapy is a targeted intratumoral delivery of interleukin 12 (IL-12), a cytokine with anti-tumor effectiveness. Due to its immunomodulatory action, it can be used as an imunostimulating component to in situ vaccinating effect of local ablative therapies. We have developed a phIL12 plasmid devoid of antibiotic resistance marker with a transgene for human IL-12 p70 protein. The plasmid can be delivered intratumorally by gene electrotransfer (GET).

Patients and methods

Here we present a first-in-human clinical trial protocol for phIL12 GET (ISRCTN15479959, ClinicalTrials NCT05077033). The study is aimed at evaluating the safety and tolerability of phIL12 GET in treatment of basal cell carcinomas in patients with operable tumors in the head and neck region. The study is designed as an exploratory, dose escalating study with the aim to determine the safety and tolerability of the treatment and to identify the dose of plasmid phIL12 that is safe and elicits its biological activity.

Conclusions

The results of this trail protocol will therefore provide the basis for the use of phIL12 GET as an adjuvant treatment to local ablative therapies, to potentially increase their local and elicit a systemic response.
Konsep Desain Lapangan Puputan Klungkung sebagai Taman Rekreasi
Authors: Balconis Anak Agung Trinanda Benczad , Semarajaya Cokorda Gede Alit , Astawa I Nyoman Gede
Published: May 2022

The design concept of Lapangan Puputan Klungkung as a recreational park. Public space is an inseparable part of a city. Lapangan Puputan Klungkung is one of the public spaces in the city center of Klungkung Regency that provides sports and recreation facilities for the community. The government plans to organize this public space as a community recreation facility to improve the quality of public recreation spaces. This research aims to produce a representative concept design of public recreation space for local communities. It used the survey method and the data were collected through field observations, interviews, and literature study, and then the collected data were analyzed descriptive qualitatively which refers to the complete design process. The results indicate that the location of this site is very strategic, easy to access, and connected to nearby locations. The design concept used the "Zelfbesturend-landscap" by collaborating history with recreation. It recommends changing the name of Lapangan Puputan Klungkung to Lapangan Puputan Klungkung Ida Dewa Agung Jambe and creating a statue of Ida Dewa Agung Jambe which becomes a focal point or landmark. Lapangan Puputan Klungkung area includes a staging area, a Pancasila stage area, a rare park or children's playground, a yowana park or a sitting area, a lingsir park or a stone path reflection area, a skateboard playing area, a gym area, a photography exhibition area, a food court area, and fountain area with a statue of Ida Dewa Agung Jambe.
Desain Bahu Jalan Letjen S. Parman, Kelurahan Panjer, Kecamatan Denpasar Selatan, Kawasan Niti Mandala Renon Denpasar - Bali
Authors: Natanael Neil Haezer , Sugianthara Anak Agung Gede , Kohdrata Naniek
Published: May 2022

Letjen S. Parman Roadside design, Sumerta Kelod, County District East Denpasar. Denpasar is one out of nine districts/cities and it is the most populated in Bali Province. Rapid population growth leads to an increase in its population density that affects traffic growth in Denpasar City. Letjen S. Parman is one of the business district roads in the Renon Field area located in the heart of Denpasar City that is often used for public with or without vehicles, which makes this area dense and requires a balance of infrastructure and supporting traffic signs and signals to ensure safety and enhance convenience. Roadsides of Letjen S. Parman Road is still often converted by the public into a parking space and a marketplace. The purpose of this study was to research traffic rules along Letjen S. Parman road and users’ opinions on it. Methodology employed to conduct the study was direct survey and collecting the data by direct field observations, interviews, and questionnaires. The research revealed that, according to traffic laws, Letjen S. Parman roadsides were not supposed to be misused by road users. Pedestrians who use Letjen S. Parman roadsides also feel disturbed by road users who inappropriately turned them into parking spots or a marketplace. The result of the study is related to design recommendations to solve traffic problems along Letjen S. Parman Road as well as a point of reference for relevant agencies and government officials.
НУМЕРИЧКО МОДЕЛИРАЊЕ СТРУЈАЊА У ОТВОРЕНИМ ТОКОВИМА:ПРИМЕНА МОДИФИКОВАНЕ ЛАКС-ФРИДРИХОВЕ СМАКНУТЕ ШЕМЕ
Authors: Винокић Лука
Published: May 2022

У овом раду је анализирано струјање воде у отвореним токовима. Изложенe су основне једначине, као и сви потребни алати за формирање нумеричког модела и решавање датог проблема. Установљена су почетна непоклапања, која су накнадно коригована калибрацијом нумеричког модела и коришћењем других нумеричких метода. Добијени резултати су у складу са хидрауликом проблема и непоклапања су очекивана имајући у виду димензије лабораторијског канала. На основу овог рада се могу јасно видети предности, као и недостаци Лакс-Фридрихове шеме, а додатно и Hec-Ras-a и методе простих итерација.
MERENJE KVALITETA USLUGA U POŠTANSKOM SAOBRAĆAJU
Authors: Stanišljević Dajana
Published: May 2022

Predmet istraživanja u ovom radu je mjerenje kvaliteta usluge u poštanskom saobraćaju. Kvalitet može da se posmatra sa gledišta proizvođača (povezuje se sa oblikovanjem i izradom proizvoda) i sa gledišta potrošača (povezuje se sa cijenom i korisnošću).
KOLORIMETRIJSKA ANALIZA REPRODUKCIJE TONOVA BOJE KOŽE NA RAZLIČITIM PAPIRNIM PODLOGAMA ŠTAMPANO INK-JET TEHNIKOM ŠTAMPE
Authors: Derdić Doris , Dedijer Sandra
Published: May 2022

U grafičkoj industriji jedan od najvaž­nijih faktora jeste da svi štampani otisci budu isti i da razlika u reprodukciji boje među njima bude minimalna, tako da je ljudsko oko ne može primetiti. Znamo da slike kože predstavljaju težak zahtev prilikom reprodukcije boja. Takođe, sama podloga za štampu može značajno uticati na reprodukciju istih. Tačnost i uniformnost reprodukcije boje u digitalnoj ink-jet tehnici štampe je takođe veoma važan zahtev koji treba biti ispunjen. Stoga predmet ovog rada jeste istraživanje reprodukcije tonova kože u digitalnoj ink-jet štampi na različitim papirnim podlogama za štampu.
KOMPARATIVNA ANALIZA PROGRAMA ZA VIZUALIZACIJU EKSTERIJERA U REALNOM VREMENU
Authors: Lesmajster Aleksandar , Tepavčević Bojan
Published: May 2022

Cilj ovog rada jeste analiza programa za izradu rendera eksterijera u realnom vremenu i odabir i poređenje uže selekcije programa koji se smatraju za najoptimalnije.
TRADICIONALNA CRNOGORSKA KUĆA SA SAVREMENOM ORGANIZACIJOM PROSTORA
Authors: Albijanić Teodora
Published: May 2022

U oblasti krasa u Crnoj Gori u mestu Godinje bilo je potrebno osmisliti stambenu kuću za porodicu. Stambena kuća zadržava spoljašni izgled tradicionalnih kuća u Crnoj Gori, ali dobija novu organizaciju prostora unutra koji prati sve potrebe savremenog čoveka i pruža mu mir i ušuškanost unutar ovog prostora. Enterijer prostorija dobija savremeni izgled, dok eksterijer ostaje jednostavan sa svim karakteristikama tradicije.
ORGANIZATIONAL AND ECONOMIC MECHANISM OF PUBLIC-PRIVATE PARTNERSHIP DEVELOPMENT IN THE FIELD OF HEALTHCARE OF UKRAINE
Authors:   Chernihiv Polytechnic National University, Zabashtanskyі Maksym , Zub Inna ,   Chernihiv Polytechnic National University, Lomonos Ruslan ,   ChernihivPolytechnic National University, Fenna Mykola ,   Chernihiv Polytechnic National University
Published: May 2022

The effectiveness of the organizational and economic mechanism for the development of public-private partnership in the fieldof health determines the level of coverage and availability of quality health services among all segments of the population, life expectancy.The need to improve the conceptual, methodological and methodological foundations of the organizational and economic mechanism of health care is of particular importance to ensure sustainable social and economic development of the state.The issue of ensuring the proper functioning of health care is particularly relevant today, given the presence of all humanity in aglobal pandemic, and reflected in the scientific works of many scientists and practitioners.Despite the existence of significant basic and applied research, which is devoted to the study of the peculiarities of the use of public-private partnership in various spheres of the national economy, the organizational and economic mechanism of its application in health care remains insufficiently disclosed.The aim of the article is to deepen the conceptual framework and develop practical recommendations necessary for the effective functioning and development of health care through the practical implementation of public-private partnership as one of the key tools for its innovative development.The purpose of developing this organizational and economic mechanism is to create basic organizational and economic conditions aimed at balanced innovative development of health care through the active involvement of private capital and new technologies. The process of building an organizational and economic mechanism for the development of public-private partnership should be systemic in nature, the fragmentary implementation of its individual components will not provide the appropriate level of effectiveness of public-private partnership in health care.
THE ROLE OF HOUSEHOLDS IN THE NATIONAL ECONOMY DEVELOPMENT
Authors:   IHE «Academician Yuriy Bugay International Scientific and Technical University», Lozychenko Oleksandr
Published: May 2022

Today, households are one of the key economic actors that play an important role in the national economydevelopment. It is these entities that produce the demand for goods, products and services that businesses try to satisfy, and are the main actors in the consumer market. These economic entities play a key role in the development of the financial services market, have the ability to produce products independently, engage in entrepreneurial activities and provide themselves with jobs. However, despite the numerous achievements of scientists in the field of research of economic aspects of the household functioning, the issues of defining and justifying the special role of these economic entities in economic development remain relevant.Within thearticle, theoretical aspects of the impact of households on the national economydevelopment are considered. For this purpose,a thorough analysis of the nature of these economic entities was conducted, and their peculiarities of functioning were determined. The analysis of scientific approaches to understanding the essence of the category "household" revealed the existence of different approaches to the consideration of this definition. However, it has been found that in the vast majority of cases, scientists consider the household as a separate economic institution, which is an association of individuals who carry out joint activities to run the household. The results of theoretical analysis of the nature of households also allowed to describe the features of their role in the national economydevelopment, justify both positive and negative potential effects that such entities can have on the functioning of the national economy. It is also noted within the articlethat households play a special role in the financial marketdevelopmentof any country, because based on their functioning, such a market generally exists. The formation of demand for credit resources, providing their own savings to financial institutions, the use of services allow financial institutions to develop, providing the national economy with the necessary financial resources
Response to the Letter to the Editor-in-Chief
Authors: Burns Scott A. , Cleland Joshua A. , Snodgrass Suzanne J.
Published: May 2022

Author response to the JOSPT Letter to the Editor-in-Chief “Treating the Hips for Low Back Pain may be Effective: For the Right Patient”.

J Orthop Sports Phys Ther 2022;52(5):300–302. doi:10.2519/jospt.2022.0202-R
Low Back Pain in Low- and Middle-Income Countries, Part 1: The Problem
Authors: Sharma Saurab , McAuley James H.
Published: May 2022

Synopsis

Low back pain (LBP) is the leading cause of disability in the low- and middle-income countries (LMICs), imposing substantial burden on individuals and health systems. The societal burden of LBP in LMICs challenges the United Nations' Sustainable Development Goals of eliminating poverty and improving health and well-being by pushing the people with the lowest socioeconomic position on the planet to greater poverty and more disability. This LBP in LMICs Series aims to (1) summarize the current state of LBP management in LMICs, (2) propose what best care for LBP in LMICs may look like, and (3) provide policy recommendations and a call to action. In this first paper, we summarize the extent of the problem: the prevalence, disability, and costs of LBP in LMICs. J Orthop Sports Phys Ther 2022;52(5):233–235. doi:10.2519/jospt.2022.11145
Molecular targets in urinary bladder cancer
Authors: Kumar Shikhar
Published: May 2022

Molecular classification of urothelial carcinoma of the bladder has revealed high mutation rates and a heterogenous variety of mutations. FGFR3 mutations are commonly detected in the Luminal-papillary subtype. Molecular targeted therapy for urothelial carcinoma is now the standard of care after disease progression on platinum/immune checkpoint inhibitor therapy. Enfortumab vedotin is preferred as there is level 1 evidence available to support its use. Erdafitinib is the first approved gene-targeted therapy for patients with FGFR3/2 alterations. Sacituzumab govitecan shows promise in early phase trials. Further results from phase 3 trials are eagerly anticipated.
Ecological, Egotistical, and Interstitial Space
Authors: DePierre Amy
Published: May 2022

This paper intentionally emulates Yi-Fu Tuan’s style of writing and assumes, at times, that the reader is familiar with Tuan’s text, Space and Place, while also, assuredly, incorporating my own language and ideas. Some of the concepts presented here may seem abstract or philosophical as these thoughts coalesced and culminated after a semester spent thinking with multiple scholars regarding the ways we inscribe meaning to place and how we inhabit space.
Denver Encampments and COVID-19: A Geographic Atlas
Authors: Briggs Lucy
Published: May 2022

The purpose of this Atlas is to answer the question, "How has COVID-19 impacted the spatial patterns of the Denver unhoused population in relation to public resources in the city core?" COVID-19 signified a crisis within a crisis for unhoused communities. Exploring the changing shelter situation, closures of public restrooms, and the ongoing sweeps in Denver illustrate the complex obstacles that unhoused individuals continue to experience.
"Ground Truth in the Loam:" Literary Mapping as Emancipation
Authors: Melotte Sarah
Published: May 2022

In the late 19th century, Ida B. Wells, a black woman from the South, urged international powers to put American racism on the map (Alderman & Inwood, 2021). She used quantitative data to display lynching sites in her famous essay, “Lynching and the Excuse for It,” written in response to Janny Addams article urging readers to give lynchers the benefit of the doubt. Ida B. Wells’ work may be the most notable example of counter - mapping, a cartographic practice that challenges institutional power by leveraging social data for activism. Countermapping is a discipline emerging from critical cartography in which individuals subvert traditional cartography by producing maps that provide alternative perspectives. Inspired by antiracist counter - mapping practices, this paper expands the notion of a map to reimagine not only the phenomena that should be mapped, but the cartographic form itself. Expanding the idea of what constitutes a map is in and of itself emancipatory, say some critical cartographic scholars (Alderman, 2021). I examine the novels, Under the Feet of Jesus by Helena Maria Viramontes and Song of Solomon by Toni Morrison, to understand how authors configure and reconfigure space to confront injustices such as racism and exploitation.
Anne Sütünden Bebeğe Geçen Kimyasal ve Toksik Maddeler
Authors: GÖKÇEN Mervenur , SEYLAM KÜŞÜMLER Aylin
Published: May 2022

Anne sütü benzersiz içeriği ile bebekler için ilk 6 ay tek başına enerji ve besin ögeleri gereksinimini karşılayan, bebeğin tüm besinsel, psikolojik ve bilişsel ihtiyaçlarını karşılayabilen bir besindir. Anne sütü hayata güzel başlamak için ilk adımdır. Bebeği birçok hastalıktan korumakta, uzun dönemde obezite ve diyabetin oluşmasının önüne geçebilmektedir. Anne sütü, anneyi bazı kanserlerden, tip 2 diyabetten ve depresyondan korumaktadır. Ayrıca emzirmek ağırlık kaybına yardımcı olmaktadır. Anne sütünün faydalarının yanı sıra çeşitli yollar ile anne sütüne geçen kimyasal bulaşanlar toksik etkilerinden dolayı bebeğe zarar vermektedir. Bu yüzden anne adayları ve anneler güvenilir gıdaları tercih etmeli, konuyla ilgili yönetmeliklerin takibi sağlanarak üretici ve tüketicilere gıda güvenliği ile ilgili bilgilendirici eğitimler düzenlenmelidir. Bu derleme yazısının amacı anne sütünden bebeğe geçen kimyasal bulaşanlar ile ilgili literatürdeki verilerin incelenmesidir.