bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 2 from Hospitalisations and Cost of Inpatient Care for Physical Diseases in Survivors of Childhood Cancer in Western Australia: a Longitudinal Matched Cohort Study.
Authors: Abdalla Tasnim , Walwyn Thomas , White Daniel , Choong Catherine S. , Bulsara Max , Preen David B. , Ohan Jeneva L.
Published: September 2024

The mean cumulative count of hospitalisations for any physical-health disease by attained age, in childhood cancer survivors and their matched comparisons.
Supplementary Table S5 from HSA Adductomics Reveals Sex Differences in NHL Incidence and Possible Involvement of Microbial Translocation
Authors: Grigoryan Hasmik , Imani Partow , Sacerdote Carlotta , Masala Giovanna , Grioni Sara , Tumino Rosario , Chiodini Paolo , Dudoit Sandrine , Vineis Paolo , Rappaport Stephen M.
Published: September 2024

Supplementary Table S5: Features selected for association with NHL
Supplementary Table S4 from HSA Adductomics Reveals Sex Differences in NHL Incidence and Possible Involvement of Microbial Translocation
Authors: Grigoryan Hasmik , Imani Partow , Sacerdote Carlotta , Masala Giovanna , Grioni Sara , Tumino Rosario , Chiodini Paolo , Dudoit Sandrine , Vineis Paolo , Rappaport Stephen M.
Published: September 2024

Supplementary Table S4: Variance components, ICCs and CVs for logged peak areas
Supplementary Table S3 from HSA Adductomics Reveals Sex Differences in NHL Incidence and Possible Involvement of Microbial Translocation
Authors: Grigoryan Hasmik , Imani Partow , Sacerdote Carlotta , Masala Giovanna , Grioni Sara , Tumino Rosario , Chiodini Paolo , Dudoit Sandrine , Vineis Paolo , Rappaport Stephen M.
Published: September 2024

Supplementary Table S3: Fold changes and p-values for adducts
Supplementary Figure S3 from Characteristics of Cancer Epidemiology Studies that Employ Metabolomics: A Scoping Review
Authors: Yu Catherine T. , Farhat Zeinab , Livinski Alicia A. , Loftfield Erikka , Zanetti Krista A.
Published: September 2024

Supplementary Figure S3 shows bar graph displaying the distribution of metabolomic epidemiology studies of cancer reporting race information by race category.
Supplementary Table S1 from Variations in Genes Encoding Human Papillomavirus Binding Receptors and Susceptibility to Cervical Pre-Cancer
Authors: Mukherjee Amrita , Ye Yuanfan , Wiener Howard W. , Kuniholm Mark H. , Minkoff Howard , Michel Kate , Palefsky Joel , D'Souza Gypsyamber , Rahangdale Lisa , Butler Kenneth R. , Kempf Mirjam-Colette , Sudenga Staci L. , Aouizerat Bradley E. , Ojesina Akinyemi I. , Shrestha Sadeep
Published: September 2024

Supplementary Table S1 lists all genetic variants (SNPs) in the candidate genese associated with pre-cancer.
Supplementary Table S5 from Racial and ethnic variation in diagnostic mammography performance among women reporting a breast lump
Authors: Nyante Sarah J. , Abraham Linn , Aiello Bowles Erin J. , Lee Christoph I. , Kerlikowske Karla , Miglioretti Diana L. , Sprague Brian L. , Henderson Louise M.
Published: September 2024

Model-based comparisons of diagnostic mammography performance by race and ethnicity, among women with nonmissing data for all covariates
Supplementary Table S2 from Racial and ethnic variation in diagnostic mammography performance among women reporting a breast lump
Authors: Nyante Sarah J. , Abraham Linn , Aiello Bowles Erin J. , Lee Christoph I. , Kerlikowske Karla , Miglioretti Diana L. , Sprague Brian L. , Henderson Louise M.
Published: September 2024

Ultrasound/MRI use by age and racial/ethnic group
Supplementary Table 1 from Body Composition, Relative Dose Intensity, and Adverse Events Among Patients with Colon Cancer
Authors: Cheng En , Caan Bette J. , Cawthon Peggy M. , Evans William J. , Hellerstein Marc K. , Shankaran Mahalakshmi , Nyangau Edna , Campbell Kristin L. , Lee Catherine , Binder Alexandra M. , Meyerhardt Jeffrey A. , Schmitz Kathryn H. , Cespedes Feliciano Elizabeth M.
Published: September 2024

Supplementary Table 1. The Comparisons of Patient Characteristics in All (N = 178), CT (N = 170), DXA (N = 162), and D3Cr (N = 118) Groups
Table S1 from Associations between ambient air pollutants and clonal hematopoiesis of indeterminate potential (CHIP)
Authors: Leiser Claire L. , Whitsel Eric A. , Reiner Alexander , Rich Stephen S. , Rotter Jerome I. , Taylor Kent D. , Tracy Russel P. , Kooperberg Charles , Smith Albert Vernon , Mason JoAnn E. , Mychaleckyj Josyf C. , Bick Alexander G. , Szpiro Adam A. , Kaufman Joel D.
Published: September 2024

Supplementary table1 shows additional results for correction for sampling in the WHI cohort
Supplementary Figure S6 from Prediagnostic prescription antibiotics use and survival in colorectal cancer patients: A Swedish national register-based study
Authors: Lu Sai San Moon , Rutegård Martin , Ahmed Maghfoor , Häggström Christel , Gylfe Åsa , Harlid Sophia , Van Guelpen Bethany
Published: September 2024

Supplementary Figure S6: Sensitivity analyses for antibiotics use in relation to overall and cancer-specific survival in stage I-III and stage IV
colorectal cancer.
(A) Multilevel mix-effect analyses, assuming Weibull distribution and including operating hospitals as a second-level
variable (n =36 061). (B) Analyses limited to colon cancer patients who underwent elective surgery (n= 21 096). (C) Analyses
limited to colon cancer patients who underwent emergency surgery (n= 2 897). (D) Analyses excluding cases who died
within 90 days after surgery, i.e., fatal perioperative complications (n=35 200). (E) Multilevel mix-effect analyses, assuming
Weibull distribution and including treating hospitals as a second-level variable (n =11 242). (F) Analyses limited to cases
with complete covariate information (n= 4 729).
Supplementary Figure S3 from Prediagnostic prescription antibiotics use and survival in colorectal cancer patients: A Swedish national register-based study
Authors: Lu Sai San Moon , Rutegård Martin , Ahmed Maghfoor , Häggström Christel , Gylfe Åsa , Harlid Sophia , Van Guelpen Bethany
Published: September 2024

Supplementary Figure S3: Kaplan-Meier estimates for antibiotics use in relation to overall and cancer-specific survival in stage
I-III and stage IV colorectal cancer.
Prediagnostic antibiotics use was categorized as no use, any use, low use (1-10 days), moderate use (11-60
days), high use (61-180 days) and very high use (>180 days), based on defined daily doses. Antibiotics use during
one year before colorectal cancer diagnosis was excluded to account to account for potential use due to
undiagnosed but clinically manifest colorectal cancer. P represents P-value for the log-rank test.
Supplementary Figure S1 from Prediagnostic prescription antibiotics use and survival in colorectal cancer patients: A Swedish national register-based study
Authors: Lu Sai San Moon , Rutegård Martin , Ahmed Maghfoor , Häggström Christel , Gylfe Åsa , Harlid Sophia , Van Guelpen Bethany
Published: September 2024

Supplementary Figure S1: Model fitness test using Cox-snell residuals for different multivariable models for stage I-III
colorectal cancer.
The variables included in the multivariate models (Model 1, Model 2 and Model 3) are presented in the
statistical methods text and in Supplementary Figure S4. To perform model fitness tests, we used the Stata
commands available from: Introduction to survival analysis with Stata. UCLA: Statistical Consulting Group.
https://stats.oarc.ucla.edu/stata/seminars/stata-survival/ (accessed July 12, 2022).
Supplemental Table 5 from Germline mutations in 12 genes and risk of ovarian cancer in three population-based cohorts
Authors: Kotsopoulos Joanne , Hathaway Cassandra A. , Narod Steven A. , Teras Lauren R. , Patel Alpa V. , Hu Chunling , Yadav Siddhartha , Couch Fergus J. , Tworoger Shelley S.
Published: September 2024

Supplemental Table 5: Mutation frequencies in ovarian cancer cases and controls in the NHS, NHSII, and CPSII cohorts separately
Supplemental Table 2 from Germline mutations in 12 genes and risk of ovarian cancer in three population-based cohorts
Authors: Kotsopoulos Joanne , Hathaway Cassandra A. , Narod Steven A. , Teras Lauren R. , Patel Alpa V. , Hu Chunling , Yadav Siddhartha , Couch Fergus J. , Tworoger Shelley S.
Published: September 2024

Supplemental Table 2: Mutation frequencies in ovarian cancer cases and controls and risk of ovarian cancer in the NHS, NHSII, and CPSII cohorts combined
Supplementary Table S4 from Genome-scale methylation analysis identifies immune profiles and age acceleration associations with bladder cancer outcomes
Authors: Chen Ji-Qing , Salas Lucas A. , Wiencke John K. , Koestler Devin C. , Molinaro Annette M. , Andrew Angeline S. , Seigne John D. , Karagas Margaret R. , Kelsey Karl T. , Christensen Brock C.
Published: September 2024

Supplementary Table S4: Cox proportional hazards models of immune cell proportions and NMIBC patient outcomes (For Pheno Age Acceleration; NMIBC patients without BCG treatment; N = 512)
Supplementary Figure S5 from Genome-scale methylation analysis identifies immune profiles and age acceleration associations with bladder cancer outcomes
Authors: Chen Ji-Qing , Salas Lucas A. , Wiencke John K. , Koestler Devin C. , Molinaro Annette M. , Andrew Angeline S. , Seigne John D. , Karagas Margaret R. , Kelsey Karl T. , Christensen Brock C.
Published: September 2024

Supplementary Figure S5: Kaplan-Meier analysis of 10-year overall survival based on the grouping results from both partDSA and SS-RPMM in all NMIBC patients [For Hannum age acceleration]
Supplementary Figure S4 from Genome-scale methylation analysis identifies immune profiles and age acceleration associations with bladder cancer outcomes
Authors: Chen Ji-Qing , Salas Lucas A. , Wiencke John K. , Koestler Devin C. , Molinaro Annette M. , Andrew Angeline S. , Seigne John D. , Karagas Margaret R. , Kelsey Karl T. , Christensen Brock C.
Published: September 2024

Supplementary Figure S4: Blood immune cell profiles, age and age acceleration distribution of two clusters assigned by the SS-RPMM approach in NMIBC patients
Supplementary Figure S3 from Genome-scale methylation analysis identifies immune profiles and age acceleration associations with bladder cancer outcomes
Authors: Chen Ji-Qing , Salas Lucas A. , Wiencke John K. , Koestler Devin C. , Molinaro Annette M. , Andrew Angeline S. , Seigne John D. , Karagas Margaret R. , Kelsey Karl T. , Christensen Brock C.
Published: September 2024

Supplementary Figure S3: Semi-Supervised Recursively Partitioned Mixture Model (SS-RPMM) for 10-year overall survival (OS) in NMIBC patients [For Hannum age acceleration]
Supplementary Figure S2 from Genome-scale methylation analysis identifies immune profiles and age acceleration associations with bladder cancer outcomes
Authors: Chen Ji-Qing , Salas Lucas A. , Wiencke John K. , Koestler Devin C. , Molinaro Annette M. , Andrew Angeline S. , Seigne John D. , Karagas Margaret R. , Kelsey Karl T. , Christensen Brock C.
Published: September 2024

Supplementary Figure S2: Blood immune cell profiles, age and age acceleration distribution of three groups assigned by partDSA algorithm in NMIBC patients
Supplementary Figure S1 from Genome-scale methylation analysis identifies immune profiles and age acceleration associations with bladder cancer outcomes
Authors: Chen Ji-Qing , Salas Lucas A. , Wiencke John K. , Koestler Devin C. , Molinaro Annette M. , Andrew Angeline S. , Seigne John D. , Karagas Margaret R. , Kelsey Karl T. , Christensen Brock C.
Published: September 2024

Supplementary Figure S1: The distribution of chronological age, methylation age, age acceleration, and each immune cell profile
Supplementary Figure S2 from Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study
Authors: Pettit Rowland W. , Byun Jinyoung , Han Younghun , Ostrom Quinn T. , Coarfa Cristian , Bondy Melissa L. , Amos Christopher I.
Published: September 2024

Supplementary Figure S2. IVW multivariate MR estimation of direct impact of traits on lung squamous cell carcinoma development, conditioned on smoking (pack years per lifespan), income, and education.
Table S6 from Dietary fish and n-3 polyunsaturated fatty acid consumption, and renal cell carcinoma risk in Japan: The Japan Public Health Center-based Prospective Study
Authors: Takahashi Michiko , Sobue Tomotaka , Zha Ling , Kitamura Tetsuhisa , Iwasaki Motoki , Inoue Manami , Yamaji Taiki , Tsugane Shoichiro , Sawada Norie
Published: September 2024

Supplementary Table S5. Risk of RCC based on the energy-adjusted dietary intakes of fish and n-3 PUFA for each detection method.
Table S5 from Dietary fish and n-3 polyunsaturated fatty acid consumption, and renal cell carcinoma risk in Japan: The Japan Public Health Center-based Prospective Study
Authors: Takahashi Michiko , Sobue Tomotaka , Zha Ling , Kitamura Tetsuhisa , Iwasaki Motoki , Inoue Manami , Yamaji Taiki , Tsugane Shoichiro , Sawada Norie
Published: September 2024

Supplementary Table S5. Risk of RCC based on the energy-adjusted dietary intakes of fish and n-3 PUFA for each detection method.
Table S4 from Dietary fish and n-3 polyunsaturated fatty acid consumption, and renal cell carcinoma risk in Japan: The Japan Public Health Center-based Prospective Study
Authors: Takahashi Michiko , Sobue Tomotaka , Zha Ling , Kitamura Tetsuhisa , Iwasaki Motoki , Inoue Manami , Yamaji Taiki , Tsugane Shoichiro , Sawada Norie
Published: September 2024

Supplementary Table S4. Risk of RCC based on n-3 PUFA consumption by various subgroups.
Table S2 from Dietary fish and n-3 polyunsaturated fatty acid consumption, and renal cell carcinoma risk in Japan: The Japan Public Health Center-based Prospective Study
Authors: Takahashi Michiko , Sobue Tomotaka , Zha Ling , Kitamura Tetsuhisa , Iwasaki Motoki , Inoue Manami , Yamaji Taiki , Tsugane Shoichiro , Sawada Norie
Published: September 2024

Supplementary Table S2. Risk of RCC based on the energy-adjusted dietary intakes of fish analyzed based the cutoff of fish intake based on a previous study.
Table S1 from Dietary fish and n-3 polyunsaturated fatty acid consumption, and renal cell carcinoma risk in Japan: The Japan Public Health Center-based Prospective Study
Authors: Takahashi Michiko , Sobue Tomotaka , Zha Ling , Kitamura Tetsuhisa , Iwasaki Motoki , Inoue Manami , Yamaji Taiki , Tsugane Shoichiro , Sawada Norie
Published: September 2024

Supplementary Table S1. Details of RCC cases based on method of diagnosis.
Supplementary Table S4 from Sex-specific associations between adiponectin and leptin signaling and pancreatic cancer survival
Authors: Babic Ana , Wang Qiao-Li , Lee Alice A. , Yuan Chen , Rifai Nader , Luo Juhua , Tabung Fred K. , Shadyab Aladdin , Wactawski-Wende Jean , Saquib Nazmus , Kim Jihye , Kraft Peter , Sesso Howard D. , Buring Julie E. , Giovannucci Edward L. , Manson JoAnn E. , Stampfer Meir J. , Ng Kimmie , Fuchs Charles S. , Wolpin Brian M.
Published: September 2024

Correlation between adipokine levels and select patient characteristics
Supplementary Figure S2 from Sex-specific associations between adiponectin and leptin signaling and pancreatic cancer survival
Authors: Babic Ana , Wang Qiao-Li , Lee Alice A. , Yuan Chen , Rifai Nader , Luo Juhua , Tabung Fred K. , Shadyab Aladdin , Wactawski-Wende Jean , Saquib Nazmus , Kim Jihye , Kraft Peter , Sesso Howard D. , Buring Julie E. , Giovannucci Edward L. , Manson JoAnn E. , Stampfer Meir J. , Ng Kimmie , Fuchs Charles S. , Wolpin Brian M.
Published: September 2024

Association between adiponectin levels and pancreatic cancer mortality using spline regression.
Figure S1 from Effectiveness and Cost of an Enhanced Mailed Fecal Test Outreach Colorectal Cancer Screening Program: Findings from the PROMPT Stepped-Wedge Trial
Authors: Coronado Gloria D. , Nyongesa Denis B. , Escaron Anne L. , Petrik Amanda F. , Thompson Jamie H. , Smith Dave , Davis Melinda M. , Schneider Jennifer L. , Rivelli Jennifer S. , Laguna Tanya , Leo Michael C.
Published: September 2024

Supplementary Figure S1 shows the proportion completing FIT within 6-months of patient identification for each evaluation interval (baseline, year 1, and year 2), by study condition.
Supplementary Table S2 from Assessing a Polygenic Risk Score for Lung Cancer Susceptibility in Non-Hispanic White and Black Populations
Authors: Trendowski Matthew R. , Lusk Christine M. , Wenzlaff Angela S. , Neslund-Dudas Christine , Gadgeel Shirish M. , Soubani Ayman O. , Schwartz Ann G.
Published: September 2024

This supplementary table provides the statistical association between SNPs included in the PRS and lung cancer status.
Data from Nitrated polycyclic aromatic hydrocarbon (nitro-PAH) signatures and somatic mutations in diesel exhaust-exposed bladder tumors
Authors: Gonzalez Nicole , Rao Nina , Dean Michael , Lee Donghyuk , Hurson Amber N. , Baris Dalsu , Schwenn Molly , Johnson Alison , Prokunina-Olsson Ludmila , Friesen Melissa C. , Zhu Bin , Rothman Nathaniel , Silverman Debra T. , Koutros Stella
Published: September 2024

Abstract
Background: Diesel exhaust is a complex mixture, including polycyclic aromatic hydrocarbons (PAHs) and nitrated PAHs (nitro-PAHs), many of which are potent mutagens and possible bladder carcinogens. To explore the association between diesel exposure and bladder carcinogenesis, we examined the relationship between exposure and somatic mutations and mutational signatures in bladder tumors.
Methods: Targeted sequencing was conducted in bladder tumors from the New England Bladder Cancer Study. Using data on 797 cases and 1,418 controls, two-stage polytomous logistic regression was used to evaluate etiologic heterogeneity between bladder cancer subtypes and quantitative, lifetime estimates of respirable elemental carbon (REC), a surrogate for diesel exposure. Poisson regression was used to evaluate associations between REC and mutational signatures.
Results: We observed significant heterogeneity in the diesel-bladder cancer risk relationship, with a strong positive association among cases with high-grade, non-muscle invasive TP53-mutated tumors compared to controls (Odds Ratio(OR)Top Tertile vs.Unexposed=4.8, 95% Confidence Interval(CI)=2.2,10.5; p-trend<0.001; p-heterogeneity=0.002). In muscle-invasive tumors, we observed a positive association between diesel exposure and the nitro-PAH signatures of 1,6-dintropyrene (RR=1.93, 95% CI=1.28,2.92) and 3-nitrobenzoic acid (RR=1.97, 95% CI=1.33,2.92).
Conclusion: The relationship between diesel exhaust and bladder cancer was heterogeneous based on the presence of TP53 mutations in tumors, further supporting the link between PAH exposure and TP53 mutations in carcinogenesis. Future studies that can identify nitro-PAH signatures in exposed tumors are warranted to add human data supporting the link between diesel and bladder cancer.
Impact: This study provides additional insight into the etiology and possible mechanisms related to diesel exhaust-induced bladder cancer.
Data from Somatic mosaic chromosomal alterations and death of cardiovascular disease causes among cancer survivors
Authors: Sun Maxine , Cyr Marie-Christyne , Sandoval Johanna , Lemieux Perreault Louis-Philippe , Busque Lambert , Tardif Jean-Claude , Dubé Marie-Pierre
Published: September 2024

Abstract
Background: Cancer survivors are at an increased risk of cardiovascular disease (CVD) compared to the general population. We sought to evaluate the impact of mosaic chromosomal alterations (mCAs) on death of CVD causes, coronary artery disease (CAD) causes, and of any cause in patients with a cancer diagnosis.
Methods: The study was a prospective cohort analysis of 48,919 UK Biobank participants with a cancer diagnosis. mCAs were characterized using DNA genotyping array intensity data and long-range chromosomal phase inference. Multivariable Cox regression models were used to ascertain the associations of mCAs. Exploratory endpoints included various incident cardiovascular phenotypes.
Results: Overall, 10,070 individuals (20.6%) carried ≥1 mCA clone. In adjusted analyses, mCA was associated with an increased risk of death of CAD causes (HR: 1.37, 95% CI: 1.09-1.71, P=0.006). In sub-analyses, we found that carriers of mCAs diagnosed with kidney cancer had an increased risk of death of CVD causes (HR: 2.03, 95% CI: 1.11-3.72, P=0.022) and CAD causes (HR: 3.57, 95% CI: 1.44-8.84, P=0.006). Women diagnosed with breast cancer who carried a mCA also had a higher risk of death of CAD causes (HR: 2.46, 95% CI: 1.23-4.92, P=0.011).
Conclusions: Among cancer survivors, carriers of any mCA are at an increased risk of CAD death compared to non-carriers. Mechanistic studies should be considered to better ascertain the biological mechanisms underneath the observed associations between mCAs and cardiovascular events for specific cancer types.
Impact: There may be clinical relevance in considering mCAs in patients diagnosed with cancer and undergoing treatment.
Data from Exploring the Complex Relationship between Gut Microbiota and Risk of Colorectal Neoplasia Using Bidirectional Mendelian Randomization Analysis
Authors: Li Wanxin , Zhou Xuan , Yuan Shuai , Wang Lijuan , Yu Lili , Sun Jing , Chen Jie , Xiao Qian , Wan Zhongxiao , Zheng Ju-Sheng , Zhang Cai-Xia , Larsson Susanna C. , Farrington Susan M. , Law Philip , Houlston Richard S. , Tomlinson Ian , Ding Ke-Feng , Dunlop Malcolm G. , Theodoratou Evropi , Li Xue
Published: September 2024

AbstractBackground:
Human gut microbiome has complex relationships with the host, contributing to metabolism, immunity, and carcinogenesis.
Methods:
Summary-level data for gut microbiota and metabolites were obtained from MiBioGen, FINRISK and human metabolome consortia. Summary-level data for colorectal cancer were derived from a genome-wide association study meta-analysis. In forward Mendelian randomization (MR), we employed genetic instrumental variables (IV) for 24 gut microbiota taxa and six bacterial metabolites to examine their causal relationship with colorectal cancer. We also used a lenient threshold for nine apriori gut microbiota taxa as secondary analyses. In reverse MR, we explored association between genetic liability to colorectal neoplasia and abundance of microbiota studied above using 95, 19, and 7 IVs for colorectal cancer, adenoma, and polyps, respectively.
Results:
Forward MR did not find evidence indicating causal relationship between any of the gut microbiota taxa or six bacterial metabolites tested and colorectal cancer risk. However, reverse MR supported genetic liability to colorectal adenomas was causally related with increased abundance of two taxa: Gammaproteobacteria (β = 0.027, which represents a 0.027 increase in log-transformed relative abundance values of Gammaproteobacteria for per one-unit increase in log OR of adenoma risk; P = 7.06×10−8), Enterobacteriaceae (β = 0.023, P = 1.29×10−5).
Conclusions:
We find genetic liability to colorectal neoplasia may be associated with abundance of certain microbiota taxa. It is more likely that subset of colorectal cancer genetic liability variants changes gut biology by influencing both gut microbiota and colorectal cancer risk.
Impact:
This study highlights the need of future complementary studies to explore causal mechanisms linking both host genetic variation with gut microbiome and colorectal cancer susceptibility.
Data from The Association of Neighborhood Characteristics and Frailty in Childhood Cancer Survivors: A Report from the St. Jude Lifetime Cohort Study
Authors: Schwartz Lindsay F. , Dhaduk Rikeenkumar , Howell Carrie R. , Brinkman Tara M. , Ehrhardt Matthew J. , Delaney Angela , Srivastava Deo Kumar , Lanctot Jennifer Q. , Armstrong Gregory T. , Robison Leslie L. , Hudson Melissa M. , Ness Kirsten K. , Henderson Tara O.
Published: September 2024

Abstract
Background: Childhood cancer survivors experience reduced physiologic reserve, or frailty, earlier and more frequently than peers. In other populations, frailty is impacted by one’s neighborhood. This study’s purpose was to evaluate associations between neighborhood characteristics and frailty in childhood cancer survivors.
Methods: Participants in the St. Jude Lifetime Cohort Study with geocoded residential addresses were analyzed. Pre-frailty/Frailty was defined as having 1-2/≥3 of sarcopenia, muscle weakness, poor endurance, slow walking speed, and exhaustion from direct assessments. Neighborhood characteristics (e.g., access to exercise opportunities and healthy food, neighborhood socioeconomic status [nSES], and rurality/urbanicity) were determined using publicly available geospatial data. Nested multivariable logistic regression models identified associations between neighborhood characteristics and pre-frailty/frailty, adjusting for chronic health conditions, individual health behaviors and socio-demographics, and high-risk cancer treatment exposures.
Results: For our cohort (N=3806, 46.79% female, 81.40% white, mean age 33.63±9.91 years), compared to non-frail survivors (n=2573;67.6%), pre-frail (n=900;23.6%) and frail survivors (n=333;8.7%) were more likely to live in neighborhoods with decreased exercise opportunities (frail OR:1.62, 1.26-2.09), reduced healthy food access (pre-frail OR:1.28, 1.08-1.51; frail OR:1.36, 1.06-1.75), and lower nSES (pre-frail OR:1.31, 1.12-1.52; frail OR:1.64, 1.30-2.07). Participants had 8% increased odds (95% CI:2-14%) of being pre-frail/frail if they lived in “resource poor” neighborhoods as opposed to “resource rich” neighborhoods after adjusting for other pre-frailty/frailty risk factors.
Conclusions: The neighborhood a childhood cancer survivor resides in as an adult is associated with pre-frailty/frailty.
Impact: This study provides valuable information for creating interventions using neighborhood-level factors to mitigate frailty and improve health outcomes in survivors.
Data from The Impact of Improved Treatments on Survival of Adult US Leukemia Patients: 1990 - 2018
Authors: Howlader Nadia , Sharon Elad , Bhattacharya Manami , Ehrlich Lori A. , Richardson Nicholas C. , Gormley Nicole J. , de Claro R. Angelo , Wood Amy E. , Mariotto Angela B. , Cronin Kathleen A.
Published: September 2024

Abstract
Introduction: Molecularly targeted therapies such as tyrosine kinase inhibitors (TKIs) are effective treatments for BCR-ABL-bearing leukemias. We evaluated the impact of TKIs on historical chronic myeloid leukemia (CML) mortality trends compared to acute lymphoblastic leukemia (ALL) and chronic lymphoblastic leukemia (CLL).
Methods: Since mortality trends reflect combined effects of leukemia incidence and survival, we also evaluated the contribution of incidence and survival trends to mortality trends by subtypes. We used data from 13 US SEER registries (1992-2017) among US adults. We utilized histology codes to identify cases of CML, ALL, and CLL and death certificate data to calculate mortality. We used Joinpoint to characterize incidence (1992-2017) and mortality (1992-2018) trends by subtype and diagnosis year.
Results: For CML, mortality rates started declining in 1998 at an average rate of 12% annually. Imatinib was approved by the FDA for treating CML and ALL in 2001, leading to clear benefits for CML patients. Five-year CML survival increased dramatically over time, especially between 1996-2011, 2.3% per year on average. ALL incidence increased 1.5% annually from 1992-2017. ALL mortality decreased 0.6% annually during 1992-2012 and then stopped declining. CLL incidence fluctuated during 1992–2017 while mortality decreased 1.1% annually during 1992-2011 and at a faster rate of 3.6% per year from 2011. Five-year survival increased 0.7% per year on average during 1992-2016.
Conclusions: Survival benefit from TKIs and other novel therapies for treating leukemia subtypes has been demonstrated in clinical trials.
Impact: Our study highlights the impact of molecularly targeted therapies at the population level.
Data from Circulating Sex Hormone Levels and Risk of Gastrointestinal Cancer: Systematic Review and Meta-Analysis of Prospective Studies
Authors: Liu Zhiqiang , Zhang Yingfan , Lagergren Jesper , Li Shanshan , Li Jingru , Zhou Zhixian , Hu Zhijian , Xie Shao-Hua
Published: September 2024

Abstract
Background: Sex hormones may influence the development of gastrointestinal cancer, but evidence is inconsistent.
Methods: We systematically searched MEDLINE and Embase databases to identify prospective studies examining associations between prediagnostic circulating levels of sex hormones and risk of five gastrointestinal cancers: esophageal, gastric, liver, pancreatic, and colorectal cancer. Pooled odds ratios (ORs) and 95% confidence intervals (95%CIs) were calculated using random-effects models.
Results: Among 16,879 identified studies, 29 were included (11 cohort, 15 nested case-control, and 3 case-cohort studies). Comparing the highest versus lowest tertiles, levels of most sex hormones were not associated with the studied tumors. Higher levels of sex hormone-binding globulin (SHBG) were associated with increased risk of gastric cancer (OR=1.35; 95%CI, 1.06-1.72), but such associations were restricted in men only (OR=1.43; 95%CI, 1.10-1.85) when stratified by sex. Higher SHBG levels were associated with increased risk of liver cancer (OR=2.07; 95%CI, 1.40-3.06). Higher testosterone levels were associated with increased risk of liver cancer overall (OR=2.10; 95%CI, 1.48-2.96), particularly in men (OR=2.63; 95%CI, 1.65-4.18), Asian populations (OR=3.27; 95%CI, 1.57-6.83) and in hepatitis B surface antigen-positive individuals (OR=3.90; 95%CI, 1.43-10.64). Higher levels of SHBG and testosterone were associated with decreased risk of colorectal cancer in men (OR=0.89; 95%CI, 0.80-0.98 and OR=0.88; 95%CI, 0.80-0.97, respectively) but not in women.
Conclusions: Circulating levels of sex hormone-binding globulin and testosterone may influence the risk of gastric, liver, and colorectal cancer.
Impact: Further clarifying the role of sex hormones in the development of gastrointestinal cancer may unravel future novel targets for prevention and treatment.
Data from Cost-effectiveness of human papillomavirus (HPV) self-collection intervention on cervical cancer screening uptake among underscreened US persons with a cervix
Authors: Spees Lisa P. , Biddell Caitlin B. , Smith Jennifer S. , Des Marais Andrea C. , Hudgens Michael G. , Sanusi Busola , Jackson Sarah , Brewer Noel T. , Wheeler Stephanie B.
Published: September 2024

Abstract
Background: We evaluate the cost-effectiveness of HPV self-collection (followed by scheduling assistance for those who were HPV+ or inconclusive) compared to scheduling assistance only and usual care among underscreened persons with a cervix (PWAC).

Methods: A decision tree analysis was used to estimate the incremental cost-effectiveness ratios (ICERs), or the cost per additional PWAC screened, from the Medicaid/state and clinic perspectives. A hypothetical cohort represented 90,807 low-income, underscreened individuals. Costs and health outcomes were derived from the MyBodyMyTest-3 randomized trial except the usual care health outcomes were derived from literature. We performed probabilistic sensitivity analyses (PSA) to evaluate model uncertainty.

Results: Screening uptake was highest in the self-collection alternative (n=65,721), followed by the scheduling assistance alternative (n=34,003) and usual care (n=18,161). The self-collection alternative cost less and was more effective than the scheduling assistance alternative from the Medicaid/state perspective. Comparing the self-collection alternative to usual care, the ICERs were $284 per additional PWAC screened from the Medicaid/state perspective and $298 per additional PWAC screened from the clinic perspective. PSAs demonstrated that the self-collection alternative was cost-effective compared to usual care at a willingness-to-pay threshold of $300 per additional PWAC screened in 66% of simulations from the Medicaid/state perspective and 58% of simulations from the clinic perspective.

Conclusion: Compared to usual care and scheduling assistance, mailing HPV self-collection kits to underscreened individuals appears to be cost-effective in increasing screening uptake.

Impact: This is the first analysis to demonstrate the cost-effectiveness of mailed self-collection in the US.
Data from Pre-diagnostic 25-hydroxyvitamin D in association with cancer specific- and all-cause mortality among low income, non-Hispanic Black Americans with colorectal cancer
Authors: Lawler Thomas P. , Khankari Nikhil K. , Shu Xiao-Ou , Steinwandel Mark , Cai Qiuyin , Jurutka Peter W. , Zheng Wei , Warren Andersen Shaneda
Published: September 2024

Abstract
Background: Observational studies show high pre-diagnosis 25-hydroxyvitamin D is associated with lower mortality after colorectal cancer (CRC) diagnosis. Results from clinical trials suggest vitamin D supplementation may improve outcomes among CRC patients. Most studies included few Black Americans, who typically have lower 25-hydroxyvitamin D. We evaluated associations between serum 25-hydroxyvitamin D and mortality after CRC diagnosis among Black American cases.

Methods: Data arose from 218 Black Americans from the Southern Community Cohort Study diagnosed with CRC during follow-up (age 40-79 at enrollment). Pre-diagnostic 25-hydroxyvitamin D was measured at enrollment and categorized as deficient (<12 ng/mL), insufficient (12-19.9 ng/mL), or sufficient (≥20 ng/mL). Mortality was determined from the National Death Index. Cox proportional hazards were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between 25-hydroxyvitamin D and mortality.

Results: As a continuous exposure, higher 25-hydroxyvitamin D was associated with overall mortality (HR=0.79 [0.65-0.96] per standard deviation increase, p-trend =.02) and CRC-specific mortality (HR=0.83 [0.64-1.08], p-trend =.16). For overall mortality, associations were strongest among females (HR=0.65 [0.42-0.92]), current smokers (HR=0.61 [0.38-0.98]), and obese participants (HR=0.47 [0.29-0.77]). Compared to those with deficiency, participants with sufficient 25-hydroxyvitamin D had lower overall mortality after multivariable adjustment (HR: 0.61 [0.37-1.01]).

Conclusions: Pre-diagnosis 25-hydroxyvitamin D is inversely associated with overall and CRC-specific mortality among Black Americans with CRC. Correcting vitamin D deficiency may improve survival of these patients, particularly for obese individuals and smokers.

Impact: Our results support including more Black Americans in trials of vitamin D supplementations to improve CRC outcomes.
Data from Association Between Sleep Duration and Colorectal Adenomas: Findings from a Case-Control Study in Vietnam
Authors: Tran Chi Thi-Du. , Paragomi Pedram , Tran Mo Thi. , Nguyen Mai Vu-Tuyet. , Tuong Thuy Thi-Van. , Tran Quang Hong. , Le Linh Cu. , Pham Huong Thi-Thu. , Ha Hien Thi-Thu. , Bui Nam Chi. , Vu Hien Huy. , Ta Phuong Que. , Shrubsole Martha J. , Cai Qiuyin , Ye Fei , Le Song Huu. , Vu Khien Van. , Tran Huong TT. , Tran Thuan V. , Boffetta Paolo , Shu Xiao-Ou , Luu Hung N.
Published: September 2024

Abstract
Background. Colorectal cancer (CRC) is one of the leading cancers worldwide and in Vietnam. Adenomas are important precursors of CRC. Study on the association between sleep duration and development of colorectal adenoma (CRA) is limited, particularly among Vietnamese population.
Methods. We conducted an individually matched case-control study of 870 CRA cases and 870 controls in a large-scale colorectal screening program involving 103,542 individuals aged ≥40 years old in Hanoi, Vietnam. Sleep duration was categorized in three groups: short: <6 hours/day, normal: 7-8 hours/day, and long: >8 hours/day. Conditional logistic regression was used to evaluate the association between sleep duration and adenomas risk after controlling for potential confounders.
Results. Overall, short-sleep duration was associated with increased risk of having CRA compared to normal duration (Odds Ratio-OR=1.48, 95% confidence interval-CI: 1.12-1.97). This pattern was present in both females (OR=1.58, 95% CI: 1.14-2.18) and males (OR=1.45, 95% CI: 1.08-1.93), with advanced adenomas (OR=1.61, 95% CI: 1.09-2.38) and non-advanced adenomas (OR=1.66, 95% CI: 1.19-2.32). Furthermore, the association between CRA development and short sleep duration was more apparent among females who were non-drinker, non-obese, physically active, with proximal or both sided adenomas and with cardiometabolic disorder. Among males, the short sleep duration was associated with CRA risk among never-smoking, cardiometabolic disorders and obese.
Conclusions. Short sleep duration was associated with increased prevalence of both advanced and non-advanced CRAs among Vietnamese population.
Impact. Findings from the current study showed that maintaining an adequate sleep duration may have an important implication for CRC prevention and control.
Data from Intake of Proton-Pump Inhibitors and Gastric Cancer Within the Stomach cancer Pooling (StoP) Project
Authors: Sassano Michele , Mariani Marco , Pelucchi Claudio , Lunet Nuno , Morais Samantha , Martín Vicente , Moreno Victor , Curado Maria Paula. , Dias-Neto Emmanuel , Leja Marcis , Gašenko Evita , La Vecchia Carlo , Boccia Stefania , Pastorino Roberta
Published: September 2024

Abstract
Background: A potential association between proton-pump inhibitors (PPIs) and gastric cancer (GC) remains undefined. Thus, we aimed to evaluate such association within the Stomach cancer Pooling (StoP) Project.

Methods: Data from five case-control studies of the StoP Project were included (1,889 cases, 6,517 controls). We assessed the impact of different exposure definitions, specifically any reported use of PPIs and exposure definitions based on the duration of PPI intake. Additionally, we modelled the dose-response relationship between cumulative duration of PPI intake and GC.

Results: Significant associations between PPI intake and GC, both overall and in the stratified analyses, were limited to exposure definitions based on short durations of intake. The overall OR for any reported PPI intake was 1.78 (95% CI: 0.76, 4.14). In the dose-response analysis, the ORs of GC were found to be higher for short durations of PPI intake (six months: OR 3.26 [95% CI: 2.40, 4.42], one year: OR 2.14 [95% CI: 1.69, 2.70], two years: OR 1.50 [95% CI: 1.22, 1.85], three years: OR 1.27 [95% CI: 1.03, 1.56]), with the association becoming not significant for durations longer than three years.

Conclusions: Our findings suggest that the observed association between PPIs and GC might be mainly due to reverse causality.

Impact: The results of this study suggest that PPIs are a safe therapeutic choice regarding their effect on the occurrence of GC.
Data from Variations in Genes Encoding Human Papillomavirus Binding Receptors and Susceptibility to Cervical Pre-Cancer
Authors: Mukherjee Amrita , Ye Yuanfan , Wiener Howard W. , Kuniholm Mark H. , Minkoff Howard , Michel Kate , Palefsky Joel , D'Souza Gypsyamber , Rahangdale Lisa , Butler Kenneth R. , Kempf Mirjam-Colette , Sudenga Staci L. , Aouizerat Bradley E. , Ojesina Akinyemi I. , Shrestha Sadeep
Published: September 2024

Abstract
Background: Cervical cancer oncogenesis starts with human papillomavirus (HPV) cell entry after binding to host cell surface receptors; however, the mechanism is not fully known. We examined polymorphisms in receptor genes hypothesized to be necessary for HPV cell entry and assessed their associations with clinical progression to pre-cancer.

Methods: African-American women (N=1728) from the MACS/WIHS Combined Cohort Study were included. Two case-control study designs were used - cases with histology-based pre-cancer (CIN3+) and controls without; and cases with cytology-based pre-cancer (HSIL) and controls without. Single nucleotide polymorphisms (SNPs) in candidate genes (SDC1, SDC2, SDC3, SDC4, GPC1, GPC2, GPC3, GPC4, GPC5, GPC6 and ITGA6) were genotyped using an Illumina Omni2.5-quad beadchip. Logistic regression was used to assess the associations in all participants and by HPV genotypes, after adjusting for age, HIV-serostatus, CD4 T-cells, and three principal components for ancestry.

Results: Minor alleles in SNPs rs77122854 (SDC3), rs73971695, rs79336862 (ITGA6), rs57528020, rs201337456, rs11987725 (SDC2), rs115880588, rs115738853 and rs9301825 (GPC5) were associated with increased odds of both CIN3+ and HSIL, whereas, rs35927186 (GPC5) was found to decrease the odds for both outcomes (p-value≤0.01). Among those infected with Alpha-9 HPV types, rs722377 (SDC3), rs16860468, rs2356798 (ITGA6), rs11987725 (SDC2), and rs3848051 (GPC5) were associated with increased odds of both pre-cancer outcomes.

Conclusions: Polymorphisms in genes that encode binding receptors for HPV cell entry may play a role in cervical pre-cancer progression.

Impact: Our findings are hypothesis generating and support further exploration of mechanisms of HPV entry genes that may help prevent progression to cervical pre-cancer.
Data from Association between outdoor light at night and prostate cancer in the Health Professionals Follow-Up Study
Authors: Chowdhury-Paulino Ilkania M. , Hart Jaime E. , James Peter , Iyer Hari S. , Wilt Grete E. , Booker Benjamin D. , Nethery Rachel C. , Laden Francine , Mucci Lorelei A. , Markt Sarah C.
Published: September 2024

Abstract
Background: Circadian disruption is a potential risk factor for advanced prostate cancer, and light at night (LAN) exposure may disrupt circadian rhythms. We evaluated whether outdoor LAN increases the risk of prostate cancer.
Methods: We prospectively followed 49,148 participants in the Health Professionals Follow-up Study from 1986 through 2016. We estimated baseline and cumulative time-varying outdoor LAN with ~1 km2 resolution using data from the US Defense Meteorological Satellite Program’s Operational Linescan System, which was assigned to participants’ geocoded addresses. Participants reside in all 50 US states and reported a work or home address. We used multivariable Cox models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association between outdoor LAN and risk of overall (7,175 cases) and fatal (915 cases) prostate cancer adjusting for individual and contextual factors.
Results: There was no association between the interquartile range increase in cumulative LAN and total (HR:1.02, 95% CI 0.98, 1.06) or fatal (HR: 1.05, 95% CI: 0.96, 1.15) prostate cancer in adjusted models. However, there was a positive association between baseline LAN and total prostate cancer among non-movers (HR: 1.06, 95% CI:1.00,1.14) including among highly screened participants (HR: 1.11, 95% CI:1.01,1.23).
Conclusions: There was a suggestive positive association between baseline outdoor LAN and total prostate cancer. Additional studies with different measures of outdoor LAN and in more diverse populations are necessary.
Impact: To our knowledge, this is the first longitudinal cohort study exploring the relationship between outdoor LAN and prostate cancer.
Data from Prediagnostic prescription antibiotics use and survival in colorectal cancer patients: A Swedish national register-based study
Authors: Lu Sai San Moon , Rutegård Martin , Ahmed Maghfoor , Häggström Christel , Gylfe Åsa , Harlid Sophia , Van Guelpen Bethany
Published: September 2024

Abstract
Background: Antibiotics use is associated with higher colorectal cancer risk, but little is known regarding any potential effects on survival.

Methods: We conducted a nationwide cohort study, using complete-population data from Swedish national registers between 2005 and 2020, to investigate prediagnostic prescription antibiotics use in relation to survival in colorectal cancer patients.

Results: We identified 36 061 stage I-III and 11 242 stage IV colorectal cancer cases diagnosed between 2010 and 2019. For stage I-III, any antibiotics use (binary yes/no variable) was not associated with overall or cancer-specific survival. Compared to no use, moderate antibiotics use (total 11-60 days) was associated with slightly better cancer-specific survival (adjusted hazard ratio (aHR) = 0.93, 95% confidence interval (CI) 0.86-0.99), whereas very high use (>180 days) was associated with worse survival (overall survival aHR = 1.42, 95% CI 1.26-1.60, cancer-specific survival aHR =1.31, 95% CI 1.10-1.55). In analyses by different antibiotic types, although not statistically significant, worse survival outcomes were generally observed across several antibiotics, particularly macrolides and/or lincosamides. In stage IV colorectal cancer, inverse relationships between antibiotics use and survival were noted.

Conclusions: Overall, our findings do not support any substantial detrimental effects of prediagnostic prescription antibiotics use on cancer-specific survival after colorectal cancer diagnosis, with the possible exception of very high use in stage I-III colorectal cancer. Further investigation is warranted to confirm and understand these results.

Impact: Although the study findings require confirmation, physicians probably do not need to factor in prediagnostic prescription antibiotics use in prognosticating colorectal cancer patients.
Data from Germline genetic variants associated with somatic TMPRSS2:ERG fusion status in prostate cancer: a genome-wide association study
Authors: Ma Chaoran , Wang Xiaoyu , Dai James Y. , Turman Constance , Kraft Peter , Stopsack Konrad H. , Loda Massimo , Pettersson Andreas , Mucci Lorelei A. , Stanford Janet L. , Penney Kathryn L.
Published: September 2024

Abstract
Background: The prostate cancer subtype defined by the presence of TMPRSS2:ERG has been shown to be molecularly and epidemiologically distinct. However, few studies have investigated germline genetic variants associating with TMPRSS2:ERG fusion status.

Methods: We performed a genome-wide association study with 396 TMPRSS2:ERG(+) cases, 390 TMPRSS2:ERG(-) cases and 2,386 cancer-free controls from the Physicians' Health Study (PHS), the Health Professionals Follow-up Study (HPFS), and a Seattle-based Fred Hutchinson (FH) Cancer Center Prostate Cancer Study. We applied logistic regression models to test the associations between ~5 million SNPs with TMPRSS2:ERG fusion status accounting for population stratification.

Results: We did not identify genome-wide significant variants comparing the TMPRSS2:ERG(+) to the TMPRSS2:ERG(-) prostate cancer cases in the meta-analysis. When comparing TMPRSS2:ERG(+) prostate cancer cases with controls without prostate cancer, 10 genome-wide significant SNPs on chromosome 17q24.3 were observed in the meta-analysis. When comparing TMPRSS2:ERG(-) prostate cancer cases with controls without prostate cancer, two SNPs on chromosome 8q24.21 in the meta-analysis reached genome-wide significance.

Conclusions: We observed SNPs at several known prostate cancer risk loci (17q24.3, 1q32.1, and 8q24.21) that were differentially and exclusively associated with the risk of developing prostate tumors either with or without the gene fusion.

Impact: Our findings suggest that tumors with the TMPRSS2:ERG fusion exhibit a different germline genetic etiology compared to fusion negative cases.
Figure S6 from Preclinical Efficacy of the Antibody-Drug-Conjugate CLDN6-23-ADC for the Treatment of CLDN6 Positive Solid Tumors
Authors: McDermott Martina S.J. , O'Brien Neil A. , Hoffstrom Benjamin , Gong KeWei , Lu Ming , Zhang Jun , Luo Tong , Liang Min , Jia Weiping , Hong Jenny , Chau Kevin , Davenport Simon , Xie Bin , Press Michael F. , Panayiotou Richard , Handly-Santana Abram , Brugge Joan S. , Presta Leonard , Glaspy John , Slamon Dennis J.
Published: September 2024

Supplemental Figure S6: In vivo efficacy of a range of doses of CLDN6-23-ADC in M202 xenograft models. ADC dosing is IV QW as indicated by the arrows