bluuebunny/crossref_metadata_2025 huggingface dataset:
Angiotensin-converting enzyme inhibitors provide a protective effect on hypoxia-induced injury in human coronary artery endothelial cells via Nrf2 signaling and PLVAP
Authors: Zhang Qiubing , Gou Fang , Shi Ping , Xu Zhe , Yan Zhitao , He Mingfang , Yin Xiaohong , He Yuanjun , Zhang Jun
Published: February 2024

BACKGROUND: Angiotensin-converting enzyme inhibitors (ACEIs) were reported to protect from hypoxia-induced oxidative stress in coronary endothelial cells (CECs) after acute myocardial infarction (AMI). Nrf2 shows a protective effect in hypoxia-induced CECs after AMI. Plasmalemma vesicle-associated protein (PLVAP) plays a pivotal role in angiogenesis after AMI. AIM: To explore the protective effect of ACEIs and the involved mechanisms under hypoxia challenge. METHODS: Human coronary endothelial cells (HCAECs) were used to establish hypoxia-induced oxidative stress injury in vitro. Flow cytometry was used to evaluate the protective effect of ACEI on hypoxia conditions.ET-1, NO, ROS, and VEGF were detected by ELISA. HO-1, Nrf2, and Keap-1, the pivotal member in the Nrf2 signaling pathway, eNOS and PLVAP were detected in HEAECs treated with ACEI by immunofluorescence, qPCR, and western blotting. RESULTS: The hypoxia ACEI or Nrf2 agonist groups showed higher cell viability compared with the hypoxia control group at 24 (61.75±1.16 or 61.23±0.59 vs. 44.24±0.58, both P < 0.05) and 48 h (41.85±1.19 or 59.64±1.13 vs. 22.98±0.25, both P < 0.05). ACEI decreased the levels of ET-1 and ROS under hypoxia challenge at 24 and 48 h (all P < 0.05); ACEI increased the VEGF and NO levels (all P < 0.05). ACEI promoted the expression level of eNOS, HO-1, Nrf2 and PLVAP but inhibited Keap-1 expression at the mRNA and protein levels (all P < 0.05). Blockade of the Nrf2 signaling pathway significantly decreased the expression level of PLVAP. CONCLUSION: ACEI protects hypoxia-treated HEAECs by activating the Nrf2 signaling pathway and upregulating the expression of PLVAP.
Investigating Preference Factors in the Design of Shopping Carts for the Elderly: A Miryoku Engineering Study
Authors: Meng Shuai-Ke , Zhang Bao-Yi , Huang Jing-Jing
Published: February 2024

By introducing the Miryoku Engineering theory, the mapping relationship between elderly shopping cart design factors and users’ perceptual imagery is explored. To design an elderly shopping cart that meets the cognitive preferences of the elderly and promotes social participation. Firstly, we collected and screened the elderly shopping carts in the market, selected representative products as experimental samples, conducted interviews and extracted design factors based on the samples. Secondly, through data analysis, specific design factors were deduced as the reference basis for the design. Finally, combined with the design orientation and analysis, the design factors were introduced to guide the innovative design of the elderly shopping cart.
Research on the Application of Traditional Culture in Product Innovation Design
Authors: Han Jian , Yu Xinran
Published: February 2024

Purpose: By analyzing the development status of traditional culture in my country, to explore the problems and difficulties encountered in product design of traditional culture in our country, to propose that traditional culture needs to be innovated and reformed, and to discuss the principles to be followed in the innovative application of traditional culture today gist. Methods: Through literature analysis, case comparison and other research methods to understand the social environment at home and abroad, to analyze the literature of traditional cultural product design innovation, and to summarize excellent design cases. Conclusion: The traditional innovative design of traditional culture needs balanced development, focusing on the regional and contemporary nature of products.
Effect of Music Therapy on the Rehabilitation of Elderly People with Dementia
Authors: Liu Zhenyu , Yao Cheng , Ying Fangtian
Published: February 2024

Objective: Evaluating the Effectiveness of Music Therapy on the Rehabilitation of Elderly People with Dementia. Methods: Twenty-four Elderly People with Dementia were selected and randomly divided into the Experimental and the Control Groups, with twelve people in each group. In the Control Group, Elderly People with Dementia were given regular care and treatment; In the Experimental Group, they were given extra twenty sessions of group music therapy. In the Experimental Part, The Mini-Mental State Examination (MMSE) and the Cornell Scale for Depression in Dementia (CSDD) were used to score and compare the twenty-four elderly People to verify their validity. Results: After treatment, the experimental group showed better MMSE and CSDD scores than the control group (P < 0.05). Conclusion: The result showed that music therapy combined with regular care and treatment could improve the cognitive function and emotional states of elderly people with dementia, alleviating their autistic symptoms and promoting rehabilitation
Research on Personalized Ceramic Bottle Design with Imagery and Neural Networks
Authors: Guo Yong-xin , Li Mimi , Chen Xiao-long
Published: February 2024

In order to meet consumer demand for ceramic bottle design, the mapping relationship between user imagery needs and ceramic bottle product form design elements is established by analysing them. Firstly, the representative samples are screened by the Delphi method, and the stylistic features of ceramic bottles are summarised by using the principle of visual simplification, secondly, the elements of ceramic bottles are modularly deconstructed by using the morphological analysis method, and the importance of the product elements is calculated by the combination of the DEMATEL and the TODIM method, and the evaluative value of the pairs of imagery words is obtained by using the Likert scale method, and representative imagery words are determined by using the KJ method and the factor analysis method. Vocabulary. A BP neural network was used to construct the modelling imagery prediction model, and the model was trained with the weights of the sample modelling elements as the input layer, and the evaluation scores of the user’s perceptual imagery as the output layer. According to the training and validation of the model, the optimal ceramic bottle shape with the best perceptual evaluation value can be predicted. This method solves the problem of designers not being able to grasp the needs of target users, improves the design efficiency of ceramic bottle products, and provides favourable support for the personalised design of ceramic bottle products.
Research on Emotional Experience Design of Cultural and Creative Products Based on User Needs
Authors: Cheng Donglin , Tan Yuanyuan , Lee Shi-le
Published: February 2024

Based on Maslow’s hierarchy of needs theory, this paper explores the application of emotional design theory in the design of traditional cultural creative products from the perspective of user needs, and studies the design strategy of user emotional innovation for products created in the modern context. Methods: Based on the theory of user pyramid model, the design elements of museum cultural and creative products were extracted through user experience demand mining by non-contact research, and the elements of user demand were quantitatively transformed by QFD model. The framework of emotional experience design for cultural and creative products was constructed in the modern context. This design framework can effectively explain the support of current design elements for emotional design.
Research on the Design of Tourism Cultural and Creative Products from the Perspective of Semiotics
Authors: Wang Zhenzhen , Wang Yu
Published: February 2024

Under the background of cultural tourism economy, this paper explores the design methods of tourism cultural and creative products. Guided by the theory of semiotics three-in-one model, using FAHP and CRITIC model, combined with game theory, this paper screens and weighs cultural symbols, and discusses their application in tourism cultural and creative product design. Taking Caishiji as an example, this paper analyzes cultural symbols from four dimensions: shape, pattern, color and material, and applies them to the design practice of tourism cultural and creative products. The evaluation results show that this design method based on cultural symbols can effectively improve the design efficiency and scientificity, and the obtained tea set design scheme can also meet the needs of users. This study is of great significance for designers to understand and use regional symbols and improve the design effect of tourism cultural and creative products.
Indoor Color Planning Based on Color Image Coordinate System
Authors: Zhou Can
Published: February 2024

Because the color configuration in most indoor space design is not ideal, in order to meet people’s physiological and psychological needs, indoor color planning based on color image coordinate system is put forward. Design an indoor color configuration system based on RGB-D image. In terms of system hardware, TCS3415 color sensor is used to design color acquisition module, and Kinect equipment is used to design RGB-D image acquisition module. In system software, RGB-D image information extraction function and indoor color configuration function are designed. The experimental results show that: according tor2The distribution table shows that when the significance level is 0.05. When the degree of freedom is 2, r2The critical value of is 5.89. Conclusion: There is no obvious difference between the system in this paper and the color scheme designed by professional designers, which verifies the effectiveness of the system.
A New Bio-Inspired Tool for Visual Design: A Cognitive Protocol Analysis
Authors: Wang Yiwen , Li Nannan , Li Biao
Published: February 2024

Designers are always looking for inspiration. Many disciplines use inspiration from nature to create something new, a practice often referred to as “bio-inspired bio-inspired”. Biology-inspired design has been widely applied and studied in engineering, architecture, products and many other disciplines, but in the field of visual design, although there are some works but few research. This article through the review of existing literature on bio-inspired design thinking, and bio-inspired interdisciplinary design development and trend of bio-inspired design in the future, in order to investigate the existing bio-inspired design tools whether can fit for visual designers, and provides a new tool for visual designers and students develop their creative development space.
Research on the Method of Artistic Image Restoration Based on Artificial Intelligence
Authors: Wang Jian
Published: February 2024

In order to improve the current inpainting algorithm for natural art images, an artistic image inpainting model is proposed by integrating artificial intelligence and embedding multi-scale attention expansion convolution. According to the uniqueness of artistic images, the network structure of DMFB is improved, and its repair model combines two plug-and-play optimization modules: extended convolution block and coordinate attention mechanism. The extended convolution module is used to capture multi-scale context information, and the coordinate attention mechanism is used to improve the remote migration ability of features of the repaired network. The combination of the two makes the repair results meet the visual visibility and semantic rationality. The experimental results show that ablation experiments are carried out to evaluate the effectiveness of each module in this model. In this paper, the hybrid extended convolution and coordinated attention mechanism are used to train the network, and the effectiveness of MADC is verified. When the expansion rate changes to 2, 4, 6 and 8, the method in this paper will lead to moderately distorted structure and fuzzy texture. On the contrary, there is no coordination attention. In the branch of mechanism, the output of this method shows texture defects and discontinuities. By using these two branches, the method in this paper has achieved good results in structure and texture. The quantitative evaluation of branches without coordinated attention mechanism is given when the expansion rate is fixed at 2, 4, 6 and 8. Conclusion: The results restored by this method are more consistent with the real image in human senses, and the objective evaluation of PSNR, SSIM and MSE has also been improved to some extent.
Knowledge Collaboration Mechanism and Validity Assessment Based on Design Awards: A Case Study of Design Intelligence Award
Authors: Zhu Jihong , Peng Peiwen , Xu Zhouping , Zhang Yixin
Published: February 2024

The essence of design award lies in the curation of outstanding design cases. Through the organizational mechanisms established by award organizers, it can serve as an exceptional platform for knowledge exchange, dissemination, and innovation. This paper introduces the concept of Design Award Knowledge Network (DAKN), taking Design Intelligence Award (DIA) for example, elucidates the collaborative mechanisms of knowledge dissemination and innovation within the DAKN, notably facilitated through the D·will Lecture and DI Project Workshops. Additionally, surveys were conducted among faculty and students participating in the series of events initiated by DIA. The findings underscore the prominent advantage of a ‘stimulative policy environment’ within this network, while revealing the need for improvements in the ‘accessibility of knowledge resources.’ This paper proposes that enhancing the vitality of DAKN rely on the diversification of knowledge, interdisciplinary approaches, and organizational collaboration. This entails the aggregation of talent from various universities, institutions, and enterprises to establish collaborative innovation teams. Through collaborative governance, the integration of diverse foundational capabilities, data information, and tool skills from various stakeholders should be orchestrated to achieve effectiveness in knowledge exchange.
Requirement Analysis of Smart Kitchen Dietary and Social Service System Based on Older Adults Mental Models
Authors: Li Fangyu , Zhu Lin , Liu Zheng , Li Lin
Published: February 2024

Using kitchen life as an entry point and the theory of mental modelling, we carried out a study on the needs analysis of a smart kitchen diet and social service system, aiming to meet the new needs of the elderly in terms of health and social interaction. Through questionnaires and user interviews, we collected and analyzed the mental data of the elderly and created a mental model of “diet and social interaction” as well as user requirements. The Analytic Hierarchy Process was used to identify the importance of dietary and social needs, covering the four demand directions of diet and nutrition, health management, social interaction, and health awareness. This study highlights the potential of user-centred research methodology in the health and social care of older people and provides useful guidance and insights for the design of future smart kitchens and related products.
Investigating the impact of the genetic variant CXCR1 (rs2234671) in individuals with urinary tract infections
Authors: Naser Hassan Hachim , Kadhim Mohanad Jawad , Almhanna Hazem
Published: February 2024

BACKGROUND: Urinary tract infections (UTIs) are currently posing a worldwide health concern by affecting millions of people. The genetic variant rs2234671 in the CXCR1-interleukin-8 receptor is closely related to a raised UTI risk. OBJECTIVES: In this work, the impact of CXCR1 (rs2234671) on UTI individuals was examined. METHODS: The demographic features of 30 recurrent UTI patients and 20 controls were thoroughly investigated. Bacterial isolation and identification were performed by the implementation of cultural and biochemical methods. DNA extraction, purification of all samples from both patients and healthy people, and IL-8 rs2234671 (C/G) SNP genotyping using T-ARMS-PCR were performed. The significance of the results was evaluated by carrying out a statistical analysis. FINDINGS: The patient’s average age was 34.63 ± 11.44 years, and controls averaged 30.30 ± 8.59 years (P= 0.156). No significant gender difference existed (P= 0.804). Escherichia coli (63.3%) was predominant, followed by Proteus mirabilis (26.7%), Enterococcus faecalis (23.3%), Klebsiella pneumoniae (10.0%), and Pseudomonas aeruginosa (20.0%). No significant association was found between bacterial species frequency, age, or sex. From the CXCR1 (rs2234671) frequency comparison, a higher GG genotype incidence in UTI patients than controls was extracted (26.7% vs. 15.0%), though not statistically significant. Risk analysis revealed that GG homozygous and C/G heterozygous genotypes were not UTI risk factors (OR = 2.47 and OR = 1.85, respectively). Moreover, the allele frequencies displayed no significant difference between the patients and controls (G allele: 66.7% vs. 66.7%; C allele: 33.3% vs. 33.3%). MAIN CONCLUSIONS: Although no significant association between CXCR1 (rs2234671) and UTI was found, the GG genotype may point to the increasing probability of UTI risk. Additional research is required to confirm and expand these conclusions.
An effectual recommendation model using hybrid learning models for early detection of Alzheimer’s disease
Authors: Sanjay V. , Swarnalatha P.
Published: February 2024

Alzheimer’s disease (AD) is a neurodegenerative disorder that affects millions of individuals worldwide, causing progressive cognitive decline. Early prediction and diagnosis the AD accurately is crucial for effective intervention and treatment. In this study, we propose a comprehensive framework for AD prediction using various techniques, including preprocessing and denoising with Multilayer Perceptron (MLP) and Ant Colony Optimization (ACO), segmentation using U-Net, and classification with Spatial Pyramid Pooling Network (SPPNet). Furthermore, we employ Convolutional Neural Network (CNN) with SPPNet for training and develop a chatbot for recommendation based on MRI data input. The preprocessing and denoising techniques play a vital role in enhancing the quality of the input data. MLP is utilized for preprocessing, where it effectively handles feature extraction and noise reduction. ACO is employed for denoising, optimizing the data to improve the signal-to-noise ratio, and enhancing the overall performance of subsequent stages. For accurate segmentation of brain regions, we employ the U-Net architecture, which has shown remarkable success in medical image segmentation tasks. U-Net effectively identifies the regions of interest, aiding in subsequent classification stages. The classification phase utilizes SPPNet, a deep learning model known for its ability to capture spatial information at multiple scales. SPPNet extracts features from segmented brain regions, enabling robust classification of AD and non-AD cases. To enhance the training process, we employ CNN with SPPNet, leveraging the power of convolutional layers to capture intricate patterns and improve predictive accuracy. The CNN-SPPNet model is trained on a large dataset of MRI scans, enabling it to learn complex representations and make accurate predictions. Hence the proposed work can be integrated with a chatbot that takes MRI data as input and provides recommendations based on the predicted AD probability. Experimental evaluation shows that the combination of preprocessing, denoising, segmentation, and classification offers a comprehensive solution for accurate and efficient AD diagnosis and management.
Can Incorrect Analysis of Time-Dependent Exposure Explain Associations between PM2.5 Exposure and Risk of Dementia?
Authors: Bachand Annette M. , Dell Linda D.
Published: February 2024

Background:

Epidemiological studies have reported positive associations between long-term exposure to particulate matter of 2.5 microns or less in diameter (PM2.5) and risk of Alzheimer’s disease and other clinical dementia. Many of these studies have analyzed data using Cox Proportional Hazards (PH) regression, which estimates a hazard ratio (HR) for the treatment (in this case, exposure) effect on the time-to-event outcome while adjusting for influential covariates. PM2.5 levels vary over time. As air quality standards for PM2.5 have become more stringent over time, average outdoor PM2.5 levels have decreased substantially.

Objective:

Investigate whether a Cox PH analysis that does not properly account for exposure that varies over time could produce a biased HR of similar magnitude to the HRs reported in recent epidemiological studies of PM2.5 and dementia risk.

Methods:

Simulation analysis.

Results:

We found that the biased HR can affect statistical analyses that consider exposure levels at event times only, especially if PM2.5 levels decreased consistently over time. Furthermore, the direction of such bias is away from the null and of a magnitude that is consistent with the reported estimates of dementia risk in several epidemiological studies of PM2.5 exposure (HR≈1.2 to 2.0).

Conclusions:

This bias can be avoided by correctly assigning exposure to study subjects throughout the entire follow-up period. We recommend that investigators provide a detailed description of how time-dependent exposure variables were accounted for in their Cox PH analyses when they report their results.
Associations Between Mid-Life Psychosocial Measures and Estimated Late Life Amyloid Burden: The Atherosclerosis Risk in Communities (ARIC)-PET Study
Authors: Groechel Renee C. , Liu Albert C. , Koton Silvia , Kucharska-Newton Anna M. , Lutsey Pamela L. , Mosley Thomas H. , Palta Priya , Sharrett A. Richey , Walker Keenan A. , Wong Dean F. , Gottesman Rebecca F.
Published: February 2024

Background:

Psychosocial factors are modifiable risk factors for Alzheimer’s disease (AD). One mechanism linking psychosocial factors to AD risk may be through biological measures of brain amyloid; however, this association has not been widely studied.

Objective:

To determine if mid-life measures of social support and social isolation in the Atherosclerosis Risk in Communities (ARIC) Study cohort are associated with late life brain amyloid burden, measured using florbetapir positron emission tomography (PET).

Methods:

Measures of social support and social isolation were assessed in ARIC participants (visit 2: 1990–1992). Brain amyloid was evaluated with florbetapir PET standardized uptake value ratios (SUVRs; visit 5: 2012–2014).

Results:

Among 316 participants without dementia, participants with intermediate (odds ratio (OR), 0.47; 95% CI, 0.25–0.88), or low social support (OR, 0.43; 95% CI, 0.22–0.83) in mid-life were less likely to have elevated amyloid SUVRs, relative to participants with high social support. Participants with moderate risk for social isolation in mid-life (OR, 0.32; 95% CI, 0.14–0.74) were less likely to have elevated amyloid burden than participants at low risk for social isolation. These associations were not significantly modified by sex or race.

Conclusions:

Lower social support and moderate risk of social isolation in mid-life were associated with lower odds of elevated amyloid SUVR in late life, compared to participants with greater mid-life psychosocial measures. Future longitudinal studies evaluating mid-life psychosocial factors, in relation to brain amyloid as well as other health outcomes, will strengthen our understanding of the role of these factors throughout the lifetime.
Melt azimuthal rotation in direct current electric arc furnace without external axial magnetic field
Authors: Pavlovs Sergejs , Jakovics Andris , Chudnovsky Alexander
Published: February 2024

This paper considers the azimuthal rotation of melt about the vertical axis of a DC EAF, which is ensured by an inclined installation of the power supply electrodes, which is a patented solution that is the basis for this article. Near inclined electrodes, the Lorentz force has a pronounced azimuthal component, which is the driver of the melt rotation without an external axial magnetic field – thus, additional energy consumption to create an external magnetic field is not necessary. The main design and technological solutions, formulated in the patent and presented by the authors, were obtained using observations and numerical LES study for a laboratory-scale experimental setup (capacity 4.8 kg of GaInSn), as well as using LES computations for an industrial-scale DC EAF (capacity 3.6 t of molten steel). Basic technological solutions studied: the flow of the melt may be controlled by varying the number of vertical and inclined electrodes of DC EAF, choosing the angle of inclination of the electrodes as well as choosing the sequence of turning on and turning off power supply through the electrodes.
Failure analysis of S30408 pipe cracking and preventive measures
Authors: Bi Dongxuan , Zhao Zizhen , Zhang Ming , Li Mengli , Su Yancai
Published: February 2024

BACKGROUND: The feed pipeline made from 30408 stainless steel of a new unit leaked during the air pressure test. OBJECTIVE: The present work aims to examine the specific cause of pipeline cracking, and providing effective approaches to avoid similar failures. METHODS: Macroscopic inspections of the cracked pipe defects were made on site immediately after leakage. Mechanical properties and hardness of specimens machined from the failed pipe were tested. In addition, microscopic analyses including material composition, microstructure observation and crack morphologies of the failed part were performed to get detail information. Composition of the feed raw material was also analyzed to identify whether it had been contaminated by corrosive elements or not. RESULTS: No impurity composition was found in the feed raw material. The element constituents, yield strength, tensile strength and hardness of the cracked pipe fulfill standard requirements. A number of scratches and defects with a size of several microns were found on the inner wall of the leaked pipe, and they were believed to be formed at the perforation step during pipeline processing. Liquation cracks were found at the pipeline butt weld joint, and they laid hidden dangers for the safety and steady operation of the pipeline. CONCLUSION: The overall analysis results indicated the pipeline leakage during air pressure test was caused by cracks initiated around inner wall defects, which sabotaged the bearing capacity of the pipe by wall thickness reduction and stress concentration. Therefore, improving the inner wall surface quality at the perforation step may help to avoid such failure. The metallurgical effect and weld stress caused during the welding process promoted the initiation and propagation of liquation cracks. The tendency of welding hot crack formation could be reduced by taking strict composition control of the welding rod and adopting reasonable welding parameters.
Combining pathological and cognitive tests scores: A novel data analytics process to improve dementia prediction models1
Authors: Alshehhi Talib , Ayesh Aladdin , Yang Yingjie , Chen Feng
Published: February 2024

BACKGROUND: The term ‘dementia’ covers a range of progressive brain diseases from which many elderly people suffer. Traditional cognitive and pathological tests are currently used to detect dementia, however, applications using Artificial Intelligence (AI) methods have recently shown improved results from improved detection accuracy and efficiency. OBJECTIVE: This research paper investigates the efficacy of one type of data analytics called supervised learning to detect Alzheimer’s disease (AD) – a common dementia condition. METHODS: The aim is to evaluate cognitive tests and common biological markers (biomarkers) such as cerebrospinal fluid (CSF) to develop predictive classification systems for dementia detection. RESULTS: A data analytics process has been proposed, implemented, and tested against real data obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) repository. CONCLUSION: The models showed good power in predicting AD levels, notably from specified cognitive tests’ scores and tauopathy related features.
La función del prototipo en la investigación a través del diseño
Authors: Cárdenas Mimendi Sigrid , Hernández Medina Elizabeth
Published: February 2024

El papel de los prototipos de diseño en la investigación, es clave para la evolución del diseño hacia una disciplina con base académica consolidada;  actualmente su desempeño plantea importantes cuestiones que permiten una discusión sobre su legitimación en la producción de conocimiento útil. Entender los distintos tipos de investigación que existen alrededor de la disciplina del diseño, también ayuda a  desarrollar una cultura que genere conocimiento orientado a la práctica y aplicación del mismo, en la sociedad y en la ciencia. La investigación a través del diseño implica normalmente la construcción de un prototipo de diseño, que constituye el núcleo del proceso de investigación.
Combinando la biotecnología con la gastronomía para brindar los alimentos del futuro
Authors: Illescas Aparicio Edgar
Published: February 2024

El desarrollo de las tecnologías alimentarias ha sido crucial para el desarrollo de la sociedad al satisfacer la seguridad alimentaria, sin embargo, el panorama a futuro parece encaminado a una crisis alimentaria por el cambio climático, el aumento poblacional y la sobreexplotación de recursos. En el presente trabajo se analizan las tecnologías emergentes que podrían ser la solución al panorama futuro como son los alimentos impresos, la obtención de aditivos naturales, el encapsulamiento de compuestos bioactivos, las innovaciones dentro de la rama de la nanobiotecnología alimentaria y la generación de alimentos sintéticos para la obtención de alimentos alternativos de origen vegetal y animal mediante el uso de microorganismos y el cultivo de células y tejidos.
Levaduras no convencionales
Authors: López Velázquez Melissa , Santoyo Paez Yuriria , Fuentes Ramírez Luis Ernesto
Published: February 2024

Las levaduras del género Saccharomyces se han descrito eficientemente en la industria, es una de las levaduras más importantes hasta el momento, con una gran historia tanto en los procesos de elaboración de cerveza, vino, panadería de las más conocidas. En la industria de la cervecería la búsqueda de nuevas levaduras diferentes a Saccharomyces con el fin de encontrar novedosos perfiles organolépticos, es algo que no se puede pasar por alto, se conocen algunos de estos microorganismos no convencionales por medio de bebidas endémicas de regiones especificas en el mundo, las cuales se caracterizan por tener perfiles organolépticos únicos, se elaboran desde hace miles de años mediante los recursos del entorno, al ser condiciones muy específicas y levaduras obtenidas del entorno es como se obtenían los componentes finales en las cervezas, en la actualidad se buscan nuevas familias de levaduras que cuenten con atributos diferenciables para la creación de nuevos perfiles de sabor y aroma de esta bebida, que es una de las más populares y consumidas a nivel mundial. En México se han realizado pocas investigaciones para la búsqueda de levaduras salvajes que posean un potencial fermentativo, y las encontradas no son diferentes a Saccharomyces, se mencionan algunas búsquedas de levaduras NO- Saccharomyces encontradas hasta el momento, el interés en este tipo de investigaciones se puede utilizar como herramienta de innovación en la industria para mejorar la competencia, marcar una diferencia en el mercado y al mismo tiempo ofrecer algo novedoso al público que disfruta de esta bebida antigua.
Habilidades visuales espaciales para la enseñanza y el aprendizaje de conceptos matemáticos
Authors: Juárez Ruiz Estela De Lourdes , Hernández Rebollar Lidia Aurora
Published: February 2024

Una de las principales teorías de la educación matemática establece que para que la comprensión de conceptos matemáticos sea efectiva, se requiere que el estudiante desarrolle diversas representaciones semióticas del objeto matemático en estudio, como son la gráfica, la simbólica y la numérica. Además, que sea capaz de trabajar dentro de cada una de ellas, así como de transitar entre las mismas por medio de conversiones con sentido, cuando realiza actividades o tareas. Específicamente, las representaciones gráficas requieren de habilidades visuales espaciales como reconocer figuras, reconstruirlas a partir de indicaciones verbales o escritas y manipularlas teniendo en cuenta los elementos de los que están formadas, entre otras. En este trabajo se presenta una descripción de habilidades visuales espaciales y cómo se pueden operacionalizar a través de descriptores para el diseño de actividades, problemas o tareas, para desarrollarlas en los estudiantes y coadyuvar en la representación gráfica de objetos matemáticos, para la mejora de los procesos de comprensión de los conceptos matemáticos.
Sensores de gas y su impacto en nuestro día a día
Authors: Lozano Rosas Ricardo , Reyes Arriaga Litzy Dolores , Vallejo Huerta Miguel Eduardo , Robles Águila María Josefina
Published: February 2024

En este trabajo se presenta un enfoque sobre la importancia de los sensores de gas en la industria, el sector salud y en el hogar. A lo largo de la historia el hombre ha tenido la necesidad de detectar gases, utilizando la nariz; ese sensor de gases que tenemos incorporado en nuestro cuerpo, pero más adelante fue inevitable desarrollar sensores que reemplazaran el sistema olfativo para evitar riesgos y aumentar la eficiencia de detección. Se presentan ejemplos de aplicación en cada uno de los sectores mencionados y se analiza la importancia en la vida del hombre. La ciencia y el desarrollo de tecnología han permitido avances en la producción de sensores que son empleados en el monitoreo de gases tóxicos, en sistemas de seguridad anti explosiones, como detectores ambientales, sistemas detectores de humo en nuestros hogares y recientemente en estrategias de detección del virus SARS-CoV-2 y reducción de riesgos de contagio en durante la pandemia COVID-19 mediante sensores de biomarcadores y monitoreo de concentraciones de CO2 respectivamente. Se hace evidente cómo los sensores de gas han ayudado a nuestra sociedad en su propósito de garantizar una mejor calidad de vida para quienes la integramos y se muestra una tendencia en el desarrollo de estos dispositivos que nos ofrece una vista al futuro próximo.
¡Proteínas al descubierto!
Authors: Reyes Hernández Rodrigo , Pimentel Salazar Laura
Published: February 2024

La biotecnología es una disciplina aplicada en el control, diagnóstico y estudio de interacciones biológicas y sus productos, empleando para ello, herramientas y técnicas moleculares innovadoras. Una de las herramientas más útiles es la proteómica, que se define como el estudio a gran escala de las proteínas, en particular de su estructura y función; a través de los años se han utilizado técnicas para identificar proteínas como la espectrofotometría de masas. Las áreas más representativas que incluyen a la proteómica como una de sus técnicas para la investigación son las que tienen que ver con la salud pública, el medio ambiente y los alimentos. Los grupos de investigación internacionales, han centrado sus esfuerzos en crear bases de datos para almacenar estructuras de proteínas, así nació el Proyecto Proteoma Humano, cuyo objetivo es construir un atlas proteico que contenga la mayoría de las mo
Virus gigantes
Authors: Leal Rivera Adrián Armando , Henández Lillo Jossvic
Published: February 2024

El descubrimiento de los virus gigantes ha causado un desafío dentro del entendimiento del concepto mismo de virus, poniendo en duda su naturaleza, su composición, tamaño, funciones y propiedades que pueden presentar, así como el papel que estos jugaron en el desarrollo de la vida, la evolución y su origen viral, brindando nuevas perspectivas para el entendimiento de estos. Por lo que en este trabajo se presenta de forma clara todo lo que uno necesita saber acerca de estos nuevos virus gigantes, plasmando las características y generalidades de estos, su impacto en los conocimientos actuales que se tienen sobre este tipo de organismos, así como las implicaciones a futuro que podrían desencadenar en la salud humana.
ACOPLAMIENTO MOLECULAR. UNA BREVE REVISIÓN A LOS AVANCES RECIENTES SOBRE CÁNCER
Authors: Ramírez-Contreras Diego
Published: February 2024

ResumenDentro del campo de la química computacional, el acoplamiento molecular o molecular docking hasido una metodología con un amplio auge. Las problemáticas actuales, tales como los elevados costos queinvolucran la investigación de nuevos fármacos, la gestión de residuos peligrosos o la remediación de espacioscontaminados, han elevado el interés en los métodos computacionales que ayudan a optimizar estos procesos.Aunque la reducción de costos que ofrece el diseño asistido por computadora es alta, se debe considerarque entre más complejos sean los sistemas que se evalúen, se incrementarán tanto el costo como el tiempoque consumen los cálculos correspondientes para realizar una predicción adecuada, resultando en un efectoinverso al buscado. Afortunadamente, tal y como fue predicho por la ley de Moore, la potencia de los nuevosprocesadores se duplica con respecto a sus predecesores cada determinado tiempo, resultando en equiposcon una capacidad de realizar más cálculos en menos tiempo y en nuevo software con menores limitacionespara realizar tareas más complejas. Lo anterior también ha beneficiado la eficacia de las herramientas pararealizar acoplamiento molecular, con lo cual a medida que se incrementa el poder de cómputo, disminuye ladificultad de evaluar sistemas más grandes y complejos.[1] El objetivo de este trabajo es proporcionar unabreve revisión de la teoría, así como de los avances realizados usando esta herramienta en la investigaciónsobre cáncer.
Níveis de gordura inerte de palma na ração para cabritos – avaliação de desempenho produtivo e comportamento ingestivo
Authors:   Universidade Federal de Uberlândia, Vilaça Lucas Eduardo Gonçalves , Oliveira Marcela Rodrigues de ,   Universidade Federal de Uberlândia, Siqueira Marco Túlio Santos ,   Universidade Federal de Lavras, Sousa Luciano Fernandes ,   Universidade Federal do Norte do Tocantins, Schultz Érica Beatriz ,   Universidade Federal de Viçosa, Macedo Junior Gilberto de Lima ,   Universidade Federal de Uberlândia
Published: February 2024

Fat sources represent an important component in ruminant feed, as they provide 2.25 times more energy than carbohydrates, and new sources, such as inert fats from rumen degradation, are a good option due to their fatty acid profile. The objective was to evaluate the performance and ingestive behavior of goats fed increasing levels of inert palm fat in the diet. Sixteen goats were used, distributed in an entirely randomized design, dairy crossbred, entire males, with initial ages of 60 days and 18.66 kg of live weight. The experiment was conducted in an entirely randomized design with repeated measures in time, with four treatments: 0, 25, 50 and 75 grams of inert palm fat per head and four repetitions per treatment. Dry matter (DM), mineral matter (MML) and organic matter (OML) intake was evaluated, and morphometric measurements of treatments and periods were compared by regression study (P<0.05). The evaluations of weight gain were done weekly and the biometric measures, ECC and evaluation of ingestive behavior, fortnightly until the end of the experiment, which lasted 60 days. Only the treatment with the lowest inclusion of inert palm fat kept the DMC below the recommended by the NRC (2007). There was no statistical difference (P>0.05) for average daily gain, weight gain, biometric variables and ingestive behavior as palm inert fat was included in the diet of goats. For the presented ECC data it is noted that it was significant (P<0.05) and increasing keeping within the range for the category. Therefore, it is noted that the use of inert palm fat supplied at different levels did not promote deleterious changes in dry matter intake, morphometric measurements and ingestive behavior.
Tinjauan Yuridis Terhadap Fenomena Kasus Penipuan Online Berbasis Responsif Gender
Authors: Saputra Afendra Eka
Published: February 2024

Aspek hukum terhadap fenomena maraknya kasus penipuan online yang sering terjadi sebagai dampak kemudahan akses internet saat ini menjadi salah satu bentuk model kejahatan responsif gender. Penulisan hukum ini bertujuan untuk memberikan pandangan dan upaya yang akan dilaksanakan oleh pemerintah untuk memberikan jaminan akan fasilitas terhadap aspek perlindungan hukum dalam konteks penanganan fenomena tindak kejahatan penipuan online berbasis gender. Metode penelitian menggunakan pendekatan normatif (Normative Approach), yaitu penelitian yang berfokus pada upaya untuk penanganan dan pencegahan tindak kejahatan kasus penipuan online berbasis gender. Hasil pemetaan terhadap implikasi nyata terkait  kajian hukum sosial yang ditimbulkan berupa efek domino terhadap dampak mental psikologis individu, perasaan termarginasi sosial, kerugian secara finansial, frekuensi ruang pergerakan yang terbatas serta timbulnya perasaan tidak aman (insecure) atas diri sendiri. Konsekuensi utama yang terjadi adalah penciptaan pandangan negatif dan penolakan masyarakat yang membuat rasa tidak aman dalam beraktivitas online. Sehingga Pemerintah perlu memfasilitasi dengan memberikan payung hukum perlindungan atas pemenuhan Hak Asasi Perempuan (HAP) berperspektif HAM dalam mencegah tindak kejahatan dan kekerasan berbasis gender.
Perlindungan Hukum Terhadap Kejadian Risiko Underwriting Dalam Asuransi Kesehatan
Authors: Saputra Afendra Eka
Published: February 2024

Underwriting, atau dalam istilah perasuransian lebih dikenal dengan sebutan risk selection, merupakan bagian dari proses identifikasi atas kemungkinan risiko dalam manajemen asuransi dari pihak subjek tertanggung, baik pribadi maupun kelompok. Pencegahan atas risiko tersebut di dalam dunia asuransi kesehatan telah diupayakan melalui pengaturan penyelenggaraan usaha perusahaan asuransi yang telah tercantum di dalam POJK 69/2016, dimana pada pasal 34 disebutkan bahwa bidang usaha komersial ataupun syariah harus mempunyai dasar panduan seleksi risiko untuk produk usaha yang dipasarkan agar pelaksanaan usaha dilakukan dengan prinsip hati-hati dan sesuai dengan standar prosedur yang telah ditetapkan. Tujuan penulisan ini adalah untuk mengetahui model perlindungan hukum pada risiko underwriting dalam asuransi kesehatan. Metode penelitian yang akan digunakan adalah model yuridis empiris, yang berarti dalam upaya mengangkat permasalahan yang diteliti menggunakan pendekatan hukum secara riil yang ada di lapangan. Hasil dari penelitian dapat diketahui bahwa bentuk legal proteksi untuk mencegah terjadinya risiko underwriting, yang pertama perusahaan asuransi kesehatan perlu untuk menyusun manajemen penilaian tingkat risiko, sehingga perusahaan wajib menyediakan ringkasan informasi produk secara tertulis. Apabila terjadi permasalahan dan sengketa, maka perusahaan wajib melakukan prosedur penyelesaian pengaduan konsumen dengan menerapkan standar Internal Dispute Resolution (IDR) dan apabila gagal diupayakan melalui Lembaga Alternatif Penyelesaian Sengketa (LAPS) yang diawasi langsung oleh OJK.
Konsep Trias Politik dan Pelaksanaannya dalam Sistem Ketatanegaraan Indonesia
Authors: Syuhada Otong
Published: February 2024

Pembentukan sebuah negara didasarkan kepada keinginan rakyat secara bersama melalui kesepakatan polititk dalamÂ Â  mencapai tatanan kehidupan yang teratur. Penelitian dilakukan dalam rangka membahas dan menganalisa sejauhmana konsep Trias Politica yang dicetuskan oleh Montesquieu, dijalankan secara penuh dalam kehidupan ketatanegaraan Indonesia.Â  Dalam konsep Tria Politica dibentuknya tiga poros kekuasaan negara yaitu, lembaga kepresidenan, lembaga pembentuk undang-undang dan lembaga kehakiman pada dasarnya bertujuan untuk menjaga agar terjadi keseimbangan dalam mengelola pemerintahan. Ketiga poros kekuasaan tersebut mempunyai peranan berbeda, namun memegang kedudukan strategis, dan diharapakan dapat saling melakukan kontrol. Namun demikian pada kenyataannya tidak semua lembaga-lembaga tersebut memiliki sepenuhnya fungsi dan kewenangan sebagaimana konsep utama Trias Politika, akibatnya seringkali terjadi tumpang tindih kewenangan, over kewenangan dan terjadi subordinasi. Adapun penelitian ini menggunakan yuridis normatif dengan menggunakan pendekatan UU dan pendekatan konseptual. Data yang digunkan adalah data sekunder. Dari hasil penelaahan ternyata penyebab tidak berjalannya konsep Trias Politica salah satunya karena adanya regulasi yang memberikan kewenangan fungsi legislatif kepada eksekutif dimana presiden diberikan hak untuk mengusulkan rancangan UU, mengeluarkan PERPPU sebagai pengganti UU produk legislatif serta dimilikinya hak prerogratif.Â  Maka dari itu penulis menyarankan untuk dilakukan kajian kembali terhadap ketentuan tersebut khususnya menyangkut kewenangan Presiden.
Contract law of Albania in the context of public-private partnerships
Authors: Kullolli Brunela
Published: February 2024

The significance of the research is underscored by the fact that Albania, as a country in the process of socio- economic development, faces the need to attract specialists for the implementation of infrastructure projects. The research seeks to explore challenges within the realm of public-private partnerships concerning contract law in Albania and to propose constructive avenues for enhancement. The methods employed in this endeavor encompassed systematisation, logical analysis, concretisation, and generalisation, along with the application of formal-legal and formal-logical approaches. The investigation analysed modern mechanisms of legal regulation in the system of public-private partnerships. Problems, including compliance with free market principles, ensuring competition and high quality of public services, have been identified. Specific steps are proposed to address them: strengthening internal control in contract awarding procedures, updating legislation with a focus on maintaining market freedom and competition, assessing, and sharing risks between the private and public sectors, and actively engaging stakeholders. The recommendations aim at organic implementation, considering the interests of all stakeholders. In addition, it is suggested that changes in the justice system should stably take place, considering the stability of the overall system. The study also delved into analysing the existing views and concepts of scholars on the subject matter. Examining various perspectives has facilitated a more profound comprehension of the intricacies surrounding the phenomenon and potential avenues for enhancing contract law in Albania within the framework of public-private partnerships. The outcomes of this research possess the potential to provide valuable insights for the formulation of effective legal measures governing contract law in the context of public-private partnerships in Albania