bluuebunny/crossref_metadata_2025 huggingface dataset:
Lysosomal cationic proteins as the basis of cellular and humoral immunity of animals: the role of neutrophil extracellular traps (NETs) in immune homeostasis (review)
Authors: Kolesnik E. A. , Derkho M. A. , Rebezov M. B.
Published: February 2025

Relevance. Lysosomal cationic proteins (LCP) of granulocytic leukocytes: elastase, cathepsin G, proteinase-3, calgranulin, cathelicidins, defensins, lactoferrin, protegrins are active against viruses, bacteria, fungi, protozoa. The issues of physiological regulatory, immune and pathological effects of LCP and their derivatives – neutrophil (heterophil) extracellular traps (NETs) on pathogens, healthy cellular and tissue structures of the body are noted.Results. The increment of LCP granulocytes is realized by: 1. merocrine type — by degranulation; 2. exocytosis and false degranulation, that is, the process of decationization of lysosomes containing granules of cationic proteins with apocrine or holocrine type of secretion. Decationization implements exocytosis of LCP, extrusion of intact lysosomes from the cell with LCP, and diffusion of LCP through the lysosome membrane. Lysosome degranulation reactions with LCP form phagolysosomes and initiate phagocytosis, lysosome decationization reactions with LCP ensure the formation and functions of NETs. NETs is formed by non-lytic (non-lytic) and lytic (lyzed) pathways in septic and aseptic inflammation, with the ontogenetic development of immune links. NETs is stereotypically formed intravascular during aseptic inflammation, oxidative stress and in a physiological regime, when granulocytes are stimulated by products of oxidative metabolism. Using a cytochemical test with a highly sensitive acid-base bromophenol blue indicator, subcellular and cellular manifestations of the physiological age-related immune activity of cationic proteins accumulated in granulocyte lysosomes were studied on the avian model organism (Aves), and nonspecific adaptive reactions (NAR) of vertebrates in early postnatal ontogenesis were studied. The basis for the formation of NAR is the relationship of groups of leukocytes (lymphocytes, monocytes and granulocytes) with the dynamics of their lysosomal cationic proteins. The method for calculating the level of activity and potential capabilities of granulocytes in phagocytic reactions and in the formation of .NETs includes indices characterizing the directions and intensity of immune reactions of granulocytes, taking into account the processes: 1. degranulation of lysosomes with LCP — in the initiation of the cellular phagocytic link; 2. decationization of lysosomes with LCP — in the initiation of extracellular traps involved in the implementation of the humoral link of immunity.
Relationship between profitability and dividend payout from industrial companies listed at Dar es Salaam Stock Exchange, Tanzania
Authors: Chindengwike James
Published: February 2025

The creation of profits is necessary in order to distribute dividends to shareholders after investment. Previous studies focused on dividend payments and macroeconomic conditions. The aim of this paper is to investigate the connection between profitability and dividend pay-out in Tanzanian industrial companies that are listed on the Dar es Salaam Stock Exchange (DSE). The study used a panel data research design and a quantitative technique. The research conducted from 2009 to 2023, 105 firm-year data points from seven industry categories were analyzed. The study was to compile significance data through documentary review. Panel data regression was used to evaluate the research data both descriptively and inferentially. The findings of the research showed a strong positive association (P < 0.005) between manufacturing firms' profitability and dividend payout. All things considered; the findings indicate that industrial enterprises listed on the DSE are primarily motivated by profit. The study suggests that manufacturing companies should raise their profitability to attract more capital and raise the dividend payment ratio.
СФЕРА ЗАСТОСУВАННЯ МОДЕЛІ CAPM У АНАЛІЗІ МЕТОДІВ ОЦІНКИ РИЗИКІВ
Authors: Гулик Тетяна , Кравець Вадим
Published: February 2025

У статті досліджується застосування моделі оцінки капітальних активів (CAPM) для аналізу інвестиційних ризиків. Це модель, розроблена для оцінки очікуваної дохідності активів, дозволяє з'ясувати ступінь ризику, пов'язаний з інвестиціями. CAPM широко використовується для прогнозування дохідності активів на основі кількох основних складових: безризикової ставки, бета-коефіцієнта, що показує чутливість активу до змін на ринку, а також премії за ризик, що є додатковим компонентом при оцінці вартості інвестицій. У статті аналізуються різні випадки застосування цієї моделі, включаючи специфічні умови ринків, зокрема на прикладі нових економічних реалій, таких як стартапи і технологічні компанії. Стаття також містить рекомендації щодо вдосконалення CAPM через інтеграцію нових економічних індикаторів і змінних, що дозволить збільшити точність оцінок ризиків у конкретних ситуаціях. Обґрунтовано існування потреби в інтеграції додаткових факторів ризику, таких як макроекономічні показники, зміни в інфляції, коливання валютних курсів і навіть політичні процеси, що можуть сильно впливати на стабільність ринків. Доведено, що прийняття фінансових рішень на основі адаптованих моделей дозволяє інвесторам знизити рівень невизначеності і підвищити ефективність інвестицій. Адаптація моделі CAPM до нових економічних реалій, врахування макроекономічних факторів і поєднання її з іншими фінансовими методами значно підвищує точність оцінки інвестиційних ризиків і дає можливість здійснювати більш обґрунтовані фінансові рішення, навіть у умовах високої економічної нестабільності, що є важливим аспектом для успіху інвестиційної діяльності в майбутньому.
УПРАВЛІННЯ ТРАНСФОРМАЦІЙНИМИ ПРОЦЕСАМИ НА РИНКУ ПРАЦІ В УМОВАХ ВОЄННИХ ВИКЛИКІВ: ТЕОРІЯ ТА ПРАКТИКА УКРАЇНИ
Authors: Бондаренко Світлана , Миляник Руслан
Published: February 2025

Стаття присвячена актуальним питанням управління трансформаційними процесами на ринку праці України в умовах воєнних викликів. Розроблено теоретико-методологічні засади та комплексну методологію оцінювання трансформаційних процесів з урахуванням глобальних факторів, воєнних викликів та локальних особливостей. Проаналізовано структурні зміни на ринку праці внаслідок повномасштабної війни та систематизовано основні тенденції трансформації. Запропоновано SMAILE-модель та механізми антикризового управління, спрямовані на подолання структурних дисбалансів, забезпечення ефективного перерозподілу трудових ресурсів, адаптацію систем соціального захисту до нових форм зайнятості. Обґрунтовано умови ефективної реалізації запропонованих механізмів в контексті післявоєнного відновлення та євроінтеграції України.
ПЕРСПЕКТИВНІ НАВИЧКИ ДЛЯ РОЗВИТКУ ЛЮДСЬКОГО КАПІТАЛУ В УМОВАХ ТРАНСФОРМАЦІЇ РИНКУ ПРАЦІ
Authors: Будякова Олена , Оборський В'ячеслав
Published: February 2025

Стаття присвячена актуальним питанням визначення перспективних навичок для розвитку людського капіталу в умовах трансформації ринку праці. Проаналізовано тренди трансформації ринку праці протягом наступних 5 років у країнах ОЕСР: співвідношення кількості вакансій до кількості безробітних, динаміку зайнятості та робочої сили, заробітної плати та продуктивності праці. Визначено, що найбільшими чинниками зростання кількості робочих місць прогнозуються сучасні технології: аналітика великих даних, технології управління кліматом, шифрування та кібербезпека, тощо. Проаналізовано показники складності пошуку нових співробітників на ринку праці в Україні у 2022-2024 рр. Визначено, що роботодавці вважають відсутність навичок та талантів найбільшими перешкодами для трансформації ринку праці, а інвестиції у навчання – найперспективнішу стратегію у сфері зайнятості. Виявлено сучасні кадрові стратегії та перспективні навички для розвитку талантів людського капіталу для ринку праці на наступні 5 роки.
ВПЛИВ ОРГАНІЗАЦІЇ ОБ’ЄДНАНИХ НАЦІЙ НА ТУРИЗМ В КОНТЕКСТІ СТАЛОГО РОЗВИТКУ
Authors: Зубайр Ахмад
Published: February 2025

У статті досліджено вплив Організації об’єднаних націй на туризм в контексті сталого розвитку. Організація об’єднаних націй – це створена в 1945 році міжнародна структура, яка об’єднала в собі 193 держави. ООН є суб’єктом міжнародного права, головним завданням якого є кооперація зусиль для покращення умов життя по всіх регіонах, подолання бідності, захист навколишнього середовища, усунення будь-яких конфліктів між країнами и формування безпечного, спокійного та розвинутого світу. ООН має великий вплив на розвиток багатьох сфер життя світу, в тому числі туристичної галузі, яка має важливе значення для розвитку окремих країн та світу в цілому. В рамках Організації об’єднаних націй діє багато важливих структур, які розділяються по галузям для більш ефективного розвитку. Наприклад, в туристичній галузі в рамках ООН діє Всесвітня туристична організація (UNWTO). Для загального розвитку економічного, соціального та інших сфер життя, подолання бідності, захисту навколишнього середовища, в 2015 році ООН прийняла резолюцію, в рамках якої були прийняти 17 цілей сталого розвитку, які також сильно вплинули на туристичну галузь. Цілі сталого розвитку були прийняті для більш швидкого та рівномірного розвитку країн та особлива увага приділяється таким важливим компонентам, як економічний, соціальний та економічний розвитку. Ці три компоненти є основою в розвитку країн та туристичної галузі. Туризм має дуже велике значення для світового розвитку. Саме туристична галузь сприяє розвитку соціальних стандартів, сфери захисту прав та свобод людини, захисту навколишнього середовища, економіки країн та інші. Туристична галузь, наприклад, має великий вплив на економічний розвиток країн. Велика частка доходів у бюджет більшості країн надходить саме з туристичної сфери, в деяких країнах туристична сфера навіть складає більш ніж 50% ВВП, що показує наскільки важливим є туризм для країн та міжнародної спільноти. Саме для підтвердження цього, 2017 рік був оголошений роком сталого розвитку туризму та Організацією об’єднаних націй зроблено акцент на тому, що це надважлива галузь.
La Design-Based Research per la progettazione di artefatti educativi: un'esperienza di ricerca
Authors: Garofano Caterina
Published: February 2025

La Design-Based Research è un approccio di ricerca mixed method che ha l'obiettivo di sviluppare nuove conoscenze e pratiche seguendo un ciclo iterativo di progettazione, prototipazione e testing di artefatti o interventi educativi. Il contributo descrive l'esperienza di progettazione di un giocattolo educativo per bambine e bambini realizzato seguendo tale impianto metodologico, illustrandone le fasi costitutive, la raccolta e l'analisi dei dati.
AI in the class: Uses, doubts, challenges and perceptions of a sample of teachers from different nationalities
Authors: Cioci Giovanna
Published: February 2025

In the post-digital context (Jandric et al., 2018; Ranieri and Bonaiuti, 2024; Eugeni, 2015), Artificial Intelligence has become a pivotal technology across many fields, including education (Hwang, Chang, 2023). This study examines teachers' use of AI, analyzing its applications, perceptions, and impacts on pedagogy. Through a questionnaire administered to N = 133 teachers, the findings reveal a limited familiarity with AI, although educators recognize its potential to personalize learning and enhance administrative efficiency. Concerns persist regarding the potential erosion of teacher authority, the risk of superficial learning, and the ethical implications of AI usage. The research emphasizes the need for targeted teacher training and a thoughtful reflection on the consequences of AI adoption in educational settings (Panciroli and Rivoltella, 2023).
Education in the Age of AI: Perceptions, Challenges and Opportunities for Italian Teachers
Authors: Toci Valentina , Nencioni Paola , Rossi Francesca
Published: February 2025

This study explores the integration of artificial intelligence (AI) in Italian education, focusing on the perceptions of teachers involved in the European AI4T project. The analysis, based on a mixed approach, shows initial optimism towards the possibilities offered by AI, such as recognition of learning and automation of tasks. However, concerns also emerge about ethical issues such as privacy, responsibility for choices made and the impoverishment of interpersonal relationships. Despite the fact that AI is recognized as useful for simplifying administrative and teaching tasks, teachers consider it essential to maintain the human element in the educational process. The contribution invites reflection on the need for ethical regulation and ongoing literacy for responsible use of AI.
Innovazione nella gestione delle competenze: il ruolo dell'e-portfolio supportato dalla GenAI nell'istruzione superiore
Authors: Di Donato Flavia
Published: February 2025

L'articolo analizza le condizioni affinché l'e-portfolio delle competenze, supportato dall'intelligenza artificiale generativa (Generative Artificial Intelligence - GenAI), rappresenti uno strumento pedagogico innovativo nell'istruzione superiore per favorire un migliore allineamento tra l'offerta di lavoro ad alta qualificazione e la domanda di competenze spesso svalutata. Grazie all'IA, è possibile modellizzare l'e-portfolio in modo più personalizzato ed equo, valorizzando le competenze trasversali e le microcredenziali, riducendo il rischio di standardizzazione eccessiva e quindi di disumanizzazione. Questo strumento consente agli studenti di documentare e riflettere sulle proprie capacità, migliorando la loro visibilità nel mercato del lavoro. Tuttavia, emergono problematiche etiche, come l'uso inappropriato degli e-portfolio da parte dei datori di lavoro per fini esclusivi, e la mancanza di trasparenza negli algoritmi che potrebbero discriminare profili atipici. La GenAI, se utilizzata in modo responsabile, può contribuire a rendere l'e-portfolio uno strumento inclusivo, riducendo le disparità e favorendo una valutazione più obiettiva e imparziale delle competenze.
The impact of Generative Artificial Intelligence (GenAI) on education: A review of the potential, the risks and the role of immersive technologies
Authors: Rossi Martina , Ciletti Michele , Melchiorre Lucia , Toto Giusi Antonia
Published: February 2025

Generative Artificial Intelligence (GenAI) is revolutionising teaching practices, offering new opportunities to personalise learning and improve the interaction between students and content. This paper aims to explore the uses of GenAI and immersive technologies in teaching practices, with a specific focus on Italian schools and universities. A review of the literature and state of the art was conducted, through the analysis of existing projects and case studies, in order to investigate how these joint technologies can enhance learning and address complex teaching challenges. Although the projects reviewed show a wide range of innovative applications that exploit GenAI and immersive technologies to enhance learning experiences, develop critical thinking and problem-solving skills, several challenges emerged in terms of accessibility and scalability of the tools.
The Prestige: tra dedizione e ossessione per la tecnica
Authors: Bidogia Luca , Piro Antonio
Published: February 2025

L'illusione del controllo e l'ossessione per la tecnica sono il cuore del film The Prestige di Christopher Nolan. Anche l'ipnosi è stata spesso associata al potere magico. L'articolo rivede il parallelismo tra ipnosi e magia per evidenziarne similitudini e differenze. I dilemmi messi in luce dalla vita dei due illusionisti del film vengono così riportati nel contesto ipnotico.
Un "millepiedi" in campo. Il pensiero sistemico-relazionale nello sport tra performance e psicoterapia per il giovane adulto
Authors: Tortorelli Daniela
Published: February 2025

L'autrice illustra alcune possibilità di applicazione dell'epistemologia sistemica in un settore applicativo della psicologia, non prettamente clinico: la psicologia dello sport. Le richieste che giungono in questo ambito celano spesso tematiche profonde e relazionali che inibiscono la piena soddisfazione nella performance e l'efficacia di un programma di preparazione mentale. Talvolta emergono disagi non inquadrabili nosograficamente: un intervento di tipo meramente tecnico centrato sul miglioramento delle abilità mentali può non funzionare se non tiene conto del contesto in cui la richiesta viene effettuata e del malessere. Il lavoro illustra teoricamente e a livello pratico con esempi le possibilità applicative del pensiero sistemico nel lavoro con giovani atleti in fase di svincolo, dando strumenti per un lavoro possibile.
Intelligenza emotiva dell'insegnante e relazione insegnante-alunno nella scuola primaria. Uno studio esplorativo
Authors: Szpunar Giordana , Mannola Chiara , Cannoni Eleonora , Grigore Madalina , Di Norcia Anna
Published: February 2025

Questo studio ha lo scopo di indagare il ruolo dell'intelligenza emotiva di docenti di scuola primaria, nella qualità della relazione insegnante-studente. La novità di questo lavoro consiste nell'uso di metodologie diversificate per dare voce sia agli insegnanti sia agli alunni allo scopo di indagare il nesso tra intelligenza emotiva dei docenti e la qualità della relazione insegnante-studente. In particolare, ai docenti sono stati somministrati due questionari self report mentre con gli alunni (età media 8,67; DS=.59) è stato utilizzato lo strumento del disegno. Si tratta, in particolare, di un primo studio esplorativo condotto su un piccolo campione composto da 6 insegnanti di classi terze e quarte e da 79 bambini. I risultati, ottenuti dai questionari e dai disegni, mettono in evidenza che le insegnanti con livelli di EI più alti hanno anche migliori relazioni con gli studenti. Invece confrontando il punto di vista di docenti e alunni sulla loro relazione si evidenzia una correlazione moderata.
Raúl Prebisch's Influence on Contemporary Development Studies: A Review of Recent Literature (2010-2021)
Authors: García-Quero Fernando
Published: February 2025

This research examines the influence of Prebisch's work on contemporary academic debates in development studies. To this end, a systematic literature review of studies published in the main development studies journals over the period 20102021 was conducted. A total of 139 articles were located and analyzed thematically. The articles were categorized according to their analytical approach, bibliographic citations, themes, treatment (anecdotal or deep), and misunderstandings and omissions of Prebisch's thought. With some exceptions, most of the articles allude to Prebisch in an anecdotal way, without delving into his thought and his extensive work. The results reveal a notable lack of knowledge about a pioneering author in development studies, especially regarding the final stage of his thought in which he tried to formulate a global theory of development. Despite this, Prebisch's thought connects with lines of research at the frontier of knowledge on the entrepreneurial state, ecologically unequal exchange, or post-extractivisms. A research and political agenda focused on his legacy requires placing at the center of the development debate issues such as the social use of surplus, the concentration of means of production, technological progress, industrialization, environmental challenges and, above all, the ethics of development.
The Conventionalist Approach in the Analysis of Unemployment
Authors: Morselli Alessandro
Published: February 2025

The purpose of this paper is to show the contribution of the conventionalist approach to the analysis of unemployment. The role of labor evaluations is highlighted. This approach leads to very different economic policy positions than those developed by neoclassical theory. Emphasis will be placed on microeconomic aspects, but in order to act in a macroeconomic context, i.e. that of conventions. In contrast to a Keynesian analysis oriented more on the quantitative problems of labor market disequilibrium, the effort here will be to show the importance of qualitative issues.
THE ROLE OF GUIDANCE AND COUNSELING TEACHERS IN OVERCOMING PESSIMISTIC ATTITUDES AND BUILDING STUDENT CONFIDENCE
Authors: Ali Karimullah , Tamam Badrut , Sutrisno Sutrisno , Subairi Subairi , Muhyatun Muhyatun
Published: February 2025

The purpose of this research is to look at the efforts or strategies used by BK teachers at SMPN 1 Waru to help students reduce pessimistic attitudes and build their self-confidence in learning activities. This research was conducted using a qualitative approach, and descriptive qualitative methods. The data collection methods used are through interview techniques, observation, and documentation. Based on the data collection efforts carried out, it is known that the BK Teacher at SMPN 1 Waru Pamekasan uses a smooth approach when helping students develop their self-confidence in learning. Apart from that, BK teachers also use classical guidance services, individual counseling, and group counseling to help students reduce their pessimistic attitude toward learning.
THE INFLUENCE OF LEADERSHIP AND MANAGEMENT COMPETENCE OF MADRASAH PRINCIPALS ON THE ENTREPRENEURIAL SPIRIT OF TEACHERS
Authors: Palah Aap Nurul , Septialonna Arip , Masitoh Masitoh , Subasman Iman
Published: February 2025

This study aims to analyze the effect of leadership and management competence of madrasah principals on the entrepreneurial spirit of teachers in MTs Kuningan Regency. The problem raised in this study is the low entrepreneurial spirit of teachers, which is allegedly closely related to leadership factors and management competencies that are not yet optimal. The novelty of this research lies in combining in-depth analysis of the relationship between educational leadership and managerial competence and its impact on entrepreneurship development in the context of Islamic education. Using qualitative methods, data were collected through in-depth interviews and document studies from various madrasahs in Kuningan Regency. The findings of this study show that the leadership of madrasah heads has a significant influence in shaping the entrepreneurial spirit of teachers, while management competencies have not had an adequate impact. The main conclusion of this study emphasizes the importance of improving the leadership capacity of madrasah principals in encouraging innovation and entrepreneurial spirit among teachers. The implication of this research is expected to be the basis of policy development and training for madrasah principals to strengthen the quality of leadership and management that is more adaptive to the needs of teachers in developing entrepreneurship.
THE URGENCY OF MICRO TEACHING PROGRAM IN MODERN ISLAMIC BOARDING SCHOOLS
Authors: Lahat Mohammad Amas , Ma’ruf Ammar , Tazali Imam
Published: February 2025

This research aims to determine the activeness of learning for each subject, using a micro-teaching program aimed at the abilities of teachers in Modern Islamic Boarding Schools. The research results show that the implementation of the micro-teaching program for teachers at Modern Islamic Boarding Schools is based on planning and micro-teaching guidelines. This is to increase the competency of students in the learning process as well as increase the competency of students in understanding the material contained in each core discussion, teacher preparation, class preparation, steps in student learning activities, and learning evaluation. Increasing the ability of language teachers means developing a spirit of love for teachers for language.
FACTORS INFLUENCING CYBER-AGGRESSION: A SYSTEMATIC REVIEW
Authors: Moesarofah Moesarofah
Published: February 2025

This systematic literature review aims to synthesize factors contributing to cyber aggression, drawn from various empirical studies. This review examines individual, social, and situational factors that shape the tendency of cyber aggression, as well as the interaction between factors. Referring to Grigg's theory, the dynamics of cyber aggression are influenced by various factors, ranging from the motivation of the perpetrator to the conditions of the social environment. Several relevant theories to explain such as Social Learning Theory, Cognitive Theory and Frustration-Aggression Theory. The research design uses a systematic literature review, from 2010-2024. Search through electronic databases: Frontiers, Elsevier, Springer, Routledge, and Google Scholar. Search keywords: "cyber aggression", and "factors that influence". After applying the inclusion criteria and removing several articles according to the research objectives, 19 articles were obtained to be identified and synthesized. The findings highlight the complex and multifactorial nature of cyber aggression, which underscores the need for a holistic approach to address this problem. This review provides a comprehensive overview of the existing literature, identifies gaps in knowledge, and offers implications for future research and practical applications.
FACTORS AFFECTING THE DEVELOPMENT OF INDEPENDENCE OF CHILDREN AGED 2-3 YEARS AT TPA X
Authors: Adhani Dwi Nurhayati , Mayangsari Dewi , Susilawati Susilawati
Published: February 2025

Early childhood autonomy is a condition where children are ready to do everything without the help of other people, including being able to be left by their parents for a while, choosing their activities, being able to use the toilet but still being helped or reminded, eating and drinking by themselves. Autonomy can be formed from two factors: 1) Internal factors, including physiological and psychological conditions, and 2) External factors, including the environment, feelings of love and affection, parenting patterns in the family, life experiences and habits. Besides being cared for at home, young children are also cared for in Daycare (TPA) because their parents work. This research aims to describe the factors that influence the development of autonomy in children aged 2-3 years in daycare settings. The type of research used is qualitative, using Miles and Huberman data analysis techniques. The stages of data analysis include data reduction, data presentation and conclusion. Data collection techniques include observation, interviews, and documentation. The research subjects are children aged 2-3 years who were entrusted to the TPA. The research results show that the factors that influence the development of independence in children aged 2-3 years at TPA to try it yourself in stages, fulfil feelings of love and affection, encourage children to communicate, and implement a democratic parenting style. Experiences that are influential in developing autonomy are playing and interacting experiences. In TPA, the dominant factors that influence the development of children's independence are habituation accompanied by direction from caregivers and adjusting to the child's character and mood.
ДО ПИТАННЯ ВИЗНАЧЕННЯ ДЕТЕРМІНАНТ КРИМІНАЛЬНО ПРОТИПРАВНОГО ЗЛОВЖИВАННЯ ВПЛИВОМ
Authors: Григорчук А. С.
Published: February 2025

Досліджено питання визначення окремих причин та умов, що детермінують кримінальні правопорушення, пов’язані зі зловживанням впливом, а саме у соціально-економічній, організаційно-управлінській, нормативно-правовій, політичній та духовній сферах життєдіяльності суспільства. З’ясовано, зокрема, що найістотнішими детермінантами зловживання впливом у соціально-економічній та духовній сферах доцільно визнати: традиційно схвальне ставлення істотної частки населення (приблизно 33%) до можливості збагачення за рахунок вчинення корупційних діянь та недостатнє матеріальне забезпечення держслужбовців нижчого та середнього рангу.
"¿Qué más quieren que hagamos?": prácticas culturales situadas en una pequeña ciudad
Authors: Ré Valeria
Published: February 2025

El artículo analiza procesos relativos a la producción cultural en Chacabuco, una pequeña ciudad no metropolitana y periférica del noroeste de la provincia de Buenos Aires (Argentina). Parte de una etnografía realizada en el conversatorio "Escala Urbana y Gestión Cultural: desafíos y estrategias", el cual fue organizado para la comunicación de resultados obtenidos en una investigación sobre el sector cultural chacabuquense entre los años 2020-2023 y dirigido a toda la comunidad. Con base en el registro de esa experiencia, desde su diseño, producción y realización, el trabajo reflexiona sobre tres cuestiones referidas a la gestión cultural orientada a la pequeña urbe: 1) la producción de las presencias institucionales y personales con base en nociones de cercanía/distancia; 2) la definición de roles y estrategias entre quienes conforman el sector cultural local; 3) la especificidad de la gestión cultural en el ámbito de lo pequeño urbano. En la descripción de esta puesta en escena se registran representaciones y tensiones que dan cuenta de las complejas relaciones que derivan de una reflexión sobre la gestión cultural desde la escala urbana
Supporting the cognitive development of individuals with intellectual disabilities through a video game for emotional regulation
Authors: Hernández-Lara Marisela , Caro Karina , Martínez-García Ana Isabel
Published: February 2025

Emotional regulation is a fundamental skill for the cognitive, social, behavioral, and academic development of individuals with intellectual disabilities. However, these individuals often face significant challenges in this area. Therapeutic interventions have been designed to improve emotional regulation. Nevertheless, most interventions and studies have been directed at other populations, such as individuals with autism spectrum disorder or ADHD. Some of them have been proven to be effective in supporting individuals with intellectual disabilities, yet a promising alternative is the use of serious games, and no specific research has been found on the use of video games for the development of emotional regulation in individuals with intellectual disabilities. This article presents the first part of the design of a video game aimed at supporting the emotional regulation of individuals with intellectual disabilities, with the goal of providing an innovative and effective tool in this field.
Innovative and future approaches for ovarian cancer detection and evaluation: a comprehensive review
Authors: Raphael Fomukong Tasinda , Nabirye Simon
Published: February 2025

Gynecological malignancies, characterized by their aggressive nature and tendency to recur, are associated with poorer outcomes and suboptimal responses to available treatment modalities. Ovarian cancer (OC) is frequently present at advanced stages, wherein therapeutic resistance, angiogenesis, recurrence, and metastatic spread significantly affect patient survival rates. The primary therapeutic approaches for this condition include surgical debulking, radiotherapy, and/or chemotherapy. Nevertheless, in the absence of targeted interventions, patients frequently experience undesirable side effects and develop resistance to pharmaceutical agents. Therefore, it is critical to understand the intricate physiology of diseases and to identify biomarkers that may help with early diagnosis or therapy response prediction. This comprehensive review seeks to critically analyze modern-day therapeutic approaches for OC, investigate innovative drug delivery mechanisms, and assess prospective biomarkers through the lens of genetic and molecular scientific inquiry. It emphasizes how technological advancements enhance disease biological processes, facilitating the identification of novel biomarkers that may refine diagnosis and prognosis, resulting in tailored medicines that improve patient survival and quality of life.
Bases neurobiológicas de la adicción a la nicotina aplicadas a su tratamiento farmacológico
Authors:   Universidad de Cartagena, Sierra Ochoa Carmen Sofia , Pastrana Arias (docente) Ariel Enrique
Published: February 2025

La epidemia de tabaquismo es una de las mayores amenazas para la salud pública que ha tenido que afrontar el mundo. Mata a más de 8 millones de personas al año, de las cuales más de 7 millones son consumidores directos y alrededor de 1,2 millones son no fumadores expuestos al humo ajeno. El tabaco es perjudicial en todas sus modalidades y no existe un nivel seguro de exposición al tabaco. El hecho de que sea legal consumirlo, su fácil adquisición y que muchas personas no lo ven como un problema de salud hace que cada día se siga consumiendo y que muchas personas empiecen a fumar desde edades muy tempranas. Es responsabilidad del médico cuando se encuentra con un paciente fumador brindarle toda la información posible sobre lo perjudicial que puede ser el tabaco para su salud y para la salud de las personas que lo rodean. Por esto es importante conocer las bases neurobiológicas de la adicción a la nicotina ya que esto nos ayuda a entender mejor como actúan los fármacos actualmente disponibles para el tratamiento del tabaquismo, y así saber que tratamiento será el más indicado para nuestro paciente en cada caso particular. El presente trabajo explica el mecanismo de acción de la nicotina en el cerebro, sus efectos y el tratamiento farmacológico. Estos conocimientos son importantes para el profesional de la salud para poder guiar a su paciente a iniciar el cese del tabaquismo, con lo cual se puede reducir la morbimortalidad en estos pacientes.
Neuroplasticidad en neuronas medianas del núcleo accumbens inducida por fentanilo
Authors:   Universidad de Cartagena, Barreto Pinto Diego Alexander , Pastrana Arias Ariel Enrique
Published: February 2025

La neuroplasticidad es la potencialidad del sistema nervioso de modificarse para formar conexiones nerviosas en respuesta a la información nueva, la estimulación sensorial, el desarrollo, la disfunción o el daño. En general, la neuroplasticidad suele asociarse al aprendizaje que tiene lugar en la infancia, pero sus definiciones van más allá y tienen un recorrido histórico. Hay diversos componentes bioquímicos y fisiológicos detrás de un proceso de neuroplasticidad y esto lleva a diferentes reacciones biomoleculares químicas, genómicas y proteómicas que requieren de acciones intra y extra neuronales para generar una respuesta neuronal. Hasta hace poco se creía que el desarrollo y recuperación del cerebro se detenían en la edad adulta, pero modernas técnicas de neuroimagen cerebral han permitido reconceptualizar la dinámica del sistema nervioso central y su funcionamiento. Hay evidencia que demuestra que el encéfalo puede cambiar para adaptarse a diversas circunstancias, no solo durante la infancia y la adolescencia, sino también durante la edad adulta e incluso en situaciones de lesión cerebral, lo que significa que el cerebro es flexible y modificable (1). La plasticidad es un proceso constante, el cual puede ser observado a diferentes zonas: sináptica, estructural y de organización de mapas neuronales. Desde hace varios años se ha reconocido el papel fundamental del principal neurotransmisor excitatorio del sistema nervioso central, el ácido glutámico, y de sus receptores en la aparición de cambios plásticos neuronales. Sin embargo, sólo en los últimos años se ha considerado la función de las moléculas transportadoras de glutamato en los fenómenos de plasticidad, tanto en la regulación de la función neuronal normal como en eventos patológicos (2). Teniendo esto en cuenta, cualquier sustancia que interactúe con estos transportadores de manera prolongada puede desencadenar este proceso de neuroplasticidad.
Efectividad de un programa de ejercicios de movilidad de cadera vs. un programa de ejercicios de estabilidad lumbar en pacientes con lumbalgia. Un ensayo clínico aleatorizado
Authors: Morones Alba Mónica , Fernández Oñate Fernanda Margarita , González Rodríguez María de Jesús , Ramírez Carreón Yesenia , Plascencia Silva Gilberto Enrique , Esparza Ramos Susana Berenice , Garcia Luque Carla Patricia
Published: February 2025

Introducción: Los ejercicios de movilidad de cadera y estabilidad lumbar son estrategias terapéuticas útiles para el manejo de la lumbalgia, pero no se han realizado estudios comparativos para determinar cuál es más efectivo. Objetivo: Comparar la efectividad de dos programas de ejercicios: movilidad de cadera (MC) y estabilidad lumbar (EL) en pacientes con lumbalgia. Material y Métodos: Ensayo clínico aleatorizado y ciego simple en pacientes de 20 a 60 años con lumbalgia sin signos de compresión nerviosa. Los participantes fueron asignados a uno de dos grupos (MC o EL) y realizaron sesiones de 30 minutos dos veces por semana durante cuatro semanas. Se evaluaron intensidad del dolor, grados de rotación de cadera, inestabilidad lumbar y nivel de discapacidad. Se emplearon pruebas de Mann-Whitney y Chi-cuadrada para comparaciones intergrupo, y Wilcoxon y McNemar para análisis intragrupo. Nivel de significancia p<0.05. Resultados: Ambos grupos mostraron mejorías significativas en todas las variables (p<0.05). Sin embargo, las comparaciones intergrupo no revelaron diferencias estadísticamente significativas en intensidad del dolor (p=0.605), inestabilidad lumbar (p=0.799), ni nivel de discapacidad (p=0.916), indicando efectividad similar entre los programas. Conclusiones: Los programas de movilidad de cadera y estabilidad lumbar son igualmente efectivos para reducir el dolor, mejorar la estabilidad y disminuir la discapacidad en pacientes con lumbalgia.
 
Recepción: 28/11/2022
Aprobación: 13/01/2025
The Pen is the Sword: The Language of Battle in Veronica Franco’s Terze Rime
Authors: Ugolini Paola
Published: February 2025

This article analyzes Veronica Franco’s use of the language of battle and swordsmanship in her Terze Rime, paying particular attention to the poems she wrote in response to a literary attack from an anonymous male writer (usually identified as Maffio Venier). In these texts, Franco describes the act of writing as a sword fight and represents herself as a skilled fencer. I consider Franco’s language of battle and her self-identification as a fighter in relation to the figure of the woman warrior popularized by Renaissance chivalric epics. Moreover, I explore the connections among Franco, her Terze Rime, and the Venetian cult of female figures—most significantly Saint Justina and the Virgin Mary—often represented as defenders of Venetian freedom. More broadly, this article investigates how Franco’s image of the pen as a weapon relates both to contemporary reflections on the position of women in society, as well as on the role and function of the writer in Renaissance Italy.
ANÁLISE DO USO E OCUPAÇÃO DO SOLO EM ÁREAS DE PRESERVAÇÃO PERMANENTE DO MUNICÍPIO DE PATOS-PB
Authors: Vieira Vinicius da Silva , Anjos Denize Monteiro dos , Queiroz Jose Henrique Maciel de , Barros Milena Oliveira Nery de
Published: February 2025

Este estudo visou identificar os possíveis impactos ambientais decorrentes do uso e ocupação desordenada em Áreas de Preservação Permanente (APPs) do município de Patos/PB. Mais especificamente, foram analisadas as APPs de três cursos d'água, o Riacho da Cruz, o Rio Espinharas e um derivado do Rio Espinharas no bairro Belo Horizonte. A delimitação das APPs foi realizada com o software QGIS e o complemento Google Hybrid, gerando buffers conforme os limites estabelecidos na Lei Municipal nº 3.486/2006. A análise temporal revelou uma significativa diminuição das áreas verdes (de 37,22% para 8,70%) e um aumento nas edificadas (de 6,46% para 33,06%). As análises in loco revelaram a presença de áreas edificadas dentro das APPs, em desacordo com as legislações vigentes. Os principais impactos ambientais identificados incluem a supressão da vegetação, impermeabilização do solo e o descarte de resíduos sólidos e efluentes inadequados, afetando negativamente a biodiversidade e a qualidade de vida local. Recomenda-se o monitoramento e aplicação de recuperação de áreas degradadas, aliada a projetos adequados de esgoto e drenagem para mitigar os impactos do descontrole ocupacional das áreas.
Productivity and blood parameters of calves of different age groups when using a feed mixture based on humic acids
Authors: Yakubchak O. , Tyshkivskaya N. , Tyshkivsky M.
Published: February 2025

The effectiveness of the use of an organic feed mixture based on humic acids on body weight gain, average daily gains and blood parameters of calves of different age groups was analyzed. For 50 days, dairy calves aged 0 to 50 days and heifers of the experimental group aged 3–4 months were fed a feed mixture based on humic acids in the amount of 20 g/100 kg of animal body weight. The drug was added to milk (colostrum) of dairy calves and to water of heifers aged 3–4 months. The effectiveness of the use of humic acids was monitored by monitoring the body weight of animals at the beginning of the study and at the end of the study (after 50 days). Morphological, physical and biochemical blood parameters of animals were determined at the beginning of the study and at its end. Body weight of dairy calves and heifers 3–4 months age of the experimental group at the end of the experiment significantly increased (p˂0.05) and (p˂0.001), respectively, compared with the control group. Average daily gains exceeded the values of dairy calves (p˂0.001) and heifers 3-4 months of age (p˂0.05) of the control group, which indicates the ability to improve the digestibility of the diet, stimulating microbial activity in the intestine and, thus, improving the absorption of nutrients. According to the results of biochemical studies, changes in hemoglobin concentration in the blood of the experimental groups of dairy calves and heifers 3-4 months of age (p˂0.1), but they were not statistically significant. Along with this, at the end of the experiment, the heifers of the experimental group showed a slight increase in erythrocytes from 5.52±0.64 to 7.1 ± 0.60 T/l (p˂0.1) and a slight increase in the respiratory surface of erythrocytes due to an increase in the average volume of erythrocytes (p˂0.1), but these changes were not significant. The study of biochemical parameters of the blood serum of dairy calves of the experimental group indicates an increase in the concentration of total protein at the end of the experiment and total calcium at p˂0.1, but the changes were not statistically significant. In the blood serum of heifers of the experimental group of 3–4 months of age, the amount of total protein increased (p˂0.05), which indicates an improvement in the assimilation of proteins from the consumed feed. Humic acids have a positive effect on the mineral metabolism of 3–4-month-old heifers. age, in particular on the concentration of total calcium in blood serum (p˂0.05), which indicates an improvement in its absorption.
Key words: humic acids, total protein, total calcium, inorganic phosphorus, blood serum, dairy calves, heifers.
Calcium metabolism and its fractional composition in clinically healthy goats
Authors: Hotsuliak M. , Sakhniuk V.
Published: February 2025

In clinically healthy goats at 2,5–3 months and 4–4,5 months of gestation, the concentration of total calcium in the blood serum according to the current physiological limits was in the range from 2,30 to 2,62 mmol/l (2,46±0,014 and 2,34±0,030 mmol/l), in lactating animals – 1,93–2,77 mmol/l (2,40±0,020 mmol/l), including on the 0–2nd day after lambing – 2,05±0,030 mmol/l, on the 15–25th day and 50–60th day of lactation, respectively, 2,45±0,015 and 2,47±0,027 mmol/l. Optimal serum Ca concentrations were found in 52,4 % of goats (pregnant and lactating). In another 14,5 % of clinically healthy goats of different physiological groups with a slight decrease in the total calcium content in the blood serum, clinical signs of hypocalcaemia were not observed. We have established physiological limits of total calcium in the blood serum of clinically healthy goats (n=177): min – 2,20, max – 2,90 mmol/l. Within the defined limits by M±2s were 87,6 % of the studied animals. The concentration of the ionised calcium fraction in the blood serum of clinically healthy goats was in the range of 0,50–1,13 mmol/l (0,76±0,020 mmol/l), in lactating animals – 0,45–1,30 mmol/l (0,87±0,023 mmol/l), which was, respectively, 30,7 and 36,2 % of total calcium. The physiological limits of ionised calcium in the blood serum of clinically healthy goats according to M±2s are as follows: min – 0,47 mmol/l, max – 1,20 mmol/l, and in 96,6 % of the studied animals (n=177) these values were within the specified limits. The ratio of Ca total : Ca ionised in clinically healthy animals is 0,34:1. The velocity of ultrasound wave propagation through the last rib area in clinically healthy lactating goats was on average 734,7±95,9 m/s (252,5– 2500,0 m/s) against 808,2±123,6 m/s in patients with subclinical hypocalcaemia. Determination of ultrasound wave propagation through bone tissue using the echoosteometer EOM-01-C is one of the markers for assessing the state of bone mineralisation in goats.
Key words: goats, vitamin D, metabolites, total calcium, ionised calcium, concentration, echosteometry, ultrasound.
Determination of antibiotic susceptibility in isolates from dogs and cats
Authors: Chemerovska I. , Rublenko I.
Published: February 2025

Microorganisms are able to rapidly acquire antibiotic resistance through mutation, memory gene transfer and epigenetic changes. Various factors contribute to the spread of antibiotic-resistant bacteria in healthcare, agriculture/livestock, and the environment due to their irrational and excessive use. These resistant microorganisms (Escherichia coli, Staphylococcus aureus, Proteus spp.) and their genes get into the soil, air, water, agricultural waste, and wastewater treatment plants and spread in the environment. Zoonotic pathogens are particularly dangerous. Scientists and healthcare practitioners are developing global strategies, which primarily include improving the identification and monitoring of the spread of resistant pathogens. The aim of our research was to determine the sensitivity of microorganisms isolated from companion animals to antibacterial drugs. For the microbiological study, biological material was collected from different infectious processes. We found resistance to various antibiotics in Staphylococcus aureus isolates. In particular, the most resistant isolates were to ceftriaxone (7.14 %), cefazolin (5.36 %) and ampicillin (5.36 %). In the study of Staphylococcus aureus isolates, the highest resistance was found to erythromycin, lincomycin, which was significantly higher (p<0.001) compared to the obtained resistance rates to tetracycline and ceftriaxone. And in the isolated isolates of Staphylococcus epidermidis, resistance to gentamicin, erythromycin, lincomycin, cephatoxin, ampicillin was detected, which was significantly (p<0.001) higher compared to the resistance data obtained for tetracycline, ciprofloxacin, ceftriaxone. The most resistant E. coli isolates were to lincomycin (10.34 %), ceftriaxone (10.34 %), tetracycline (8.62 %) and norfloxacin (8.62 %).
Keywords: antibiotic resistance, antibiotics, spread, microorganisms, Escherichia coli, Staphylococcus aureus, Proteus spp