bluuebunny/crossref_metadata_2025 huggingface dataset:
La poesia di corrispondenza nei canzonieri di vecchia guardia aragonese
Authors: Amorino Erika
Published: January 2024

Muovendo da alcune considerazioni tratte dal celebre volume della sua lirica aragonese di Marco Santagata, il contributo indica nuove prospettive alla sua poesia meridionale attraverso la privilegiata specola della corrispondenza in versi. Il corpus considererà si compose di tutti i testi con adressee prelevati dai canzonieri di vecchia guardia, etichetta con cui, dà Carlo Dionisotti in poi, ci si riferisce a poeti come Giovanni Aloisio, Giovan Francesco Caracciolo, Pietro Jacopo De Jennaro e Giuliano Perleoni. Pur rientrando nella gamma di questa classificazione, il caso di Francesco Galeota, pur ignorando anche gli studi specialistici, costituisce un discorso a parte, non solo per il particolare contenuto-formalità che offre il suo canzoniere, ma più per l'interesse di componenti e componenti relativo al discorso sulla corrispondenza in versi.
La poesia oggettiva catalana nella Napoli aragonese
Authors: Compagna Anna Maria
Published: January 2024

Nel contesto della produzione napoletana aragonese venivano in contatto tradizioni poetiche diverse e i modelli italiani avevano la possibilità di esercitare la loro influenza su quei poeti iberici che soggiornarono più o meno a lungo presso la corte napoletana, e che si potevano esprimere non solo nelle due lingue delle zone da cui provenivano, cioè in castigliano e in catalano, ma anche nella lingua del paese in cui si trovarono, ossia l’italiano, all’interno del quale interagivano varie tradizioni linguistiche e poetiche diverse. L’esame della poesia oggettiva catalana e dell’uso al suo interno del dialogo permettono di seguire la loro evoluzione nei moduli dialogici e teatrali che si stemperano nella voce dei poeti alla corte aragonese che affiora attraverso nuove manifestazioni che riguardano festa e teatro. Il processo è reso possibile dal contatto e dalla permeabilità dei modelli, che si esplicita in una sperimentazione aperta a nuove strategie letterarie, che trovano nella poesia oggettiva catalana, e soprattutto in quella dialogica, degli antecedenti degni di sviluppo all’interno di nuove dinamiche sociali, che si manifestano attraverso le feste e il teatro che ampliano i loro spazi, acquistando anche una funzione che da gioco può farsi denuncia. Il discorso si appoggia su una documentazione aperta a ulteriori approfondimenti. Un altro tassello si aggiunge al quadro della permeabilità culturale dei modelli che si incontrano nella Napoli aragonese.
Ressenya de The Aesthetics of Melancholia: Medical and Spiritual Diseases in Medieval Iberia
Authors: Rivero Navarro Sergi
Published: January 2024

El llibre The Aesthetics of Melancholia: Medical and Spiritual Diseases in Medieval Iberia, del professor Luis F. López González i que acaba de publicar Oxford University Press és un estudi curós que ressegueix la influència de la teoria dels humors i, en particular, de la malatia de la malenconia als textos de tres autors canònics de la literatura medieval castellana: Alfonso X, Don Juan Manuel i Juan Ruiz. La tesi principal d’aquesta obra, que l’autor argumenta de forma convincent, és que la incorporació d’explicacions naturals a l’origen de les malalties dins dels textos dels segles XIII i XIV estudiats en el llibre, contribuí al desplaçament gradual del marc mental teocràtic de la societat medieval cap un altre de més humanista i científic que predominarà durant el Renaixement.
Evidências Clínicas e Características Gerais da Violência Sexual na Infância
Authors: Silva Ana Caroliny Oliveira da , Santos Rosely Leyliane dos , Silva Felipe Paulino da , Silva Micaelle de Sousa , Oliveira Vinícius Alves de Alencar , Tranquilino Ana Raiane Alencar
Published: January 2024

Objetiva-se identificar as evidências e características gerais da violência sexual na infância. Trata-se de uma revisão integrativa da literatura, realizada em dezembro de 2022, por meio do portal de periódicos da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, National Library of Medicine e Biblioteca Virtual em Saúde. A amostra correspondeu a dezessete estudos. Identificaram-se evidencias físicas, psicológicas e comportamentais e características, como vítimas do sexo feminino, idade entre 6 e 12 anos, cor de pele branca, agressores do sexo masculino, pai/padrasto da vítima, violência com penetração e a residência da vítima ou do agressor como o local do crime. As evidências clínicas apontadas, chegam aos serviços de saúde, mas raramente profissionais de saúde associam os sinais a violência sexual. Ressaltando a importância da difusão de conhecimentos sobre a temática. Espera-se que os achados contribuam para a identificação precoce e estabelecimento de estratégias para prevenção da violência sexual infantil.
Essential oils as a resource to support the mental health of academics and health-care professionals
Authors: Silva Camila Caroline da , Berbert Laura Vicentim , Sakalem Marna Eliana
Published: January 2024

Introduction: Stressful situations, common in the current world scenario, culminate in negative impacts on the mental health. Due to the busy routines, with many hours of work and study each week, academics and health care workers are among the most affected by mood and anxiety disorders, with an increasing incidence of substance abuse. Besides psychotropic medications to combat psychosomatic disorders, other intervention possibilities with fewer reports of adverse effects can be used, such as essential oils (E.O.s). Objective: To conduct a literature review to investigate possible positive effects of selected essential oils on physical and mental impacts arising from stress and anxiety. Methods: A literature review was conducted using Google Scholar, SciELO, and PubMed databases. Original papers that contained clinical research evaluating the effects of E.O.s on physical and mental health were selected. Results: The use of essential oils, most notably lavender (8 studies), lemongrass (6 studies), bergamot (3 studies) and cypress (2 studies), demonstrated to be an effective alternative for the treatment of anxiety, stress, and depression. Conclusion: The use of essential oils is effective in the support of mental disorders and is thus of great relevance to the general well-being of academics and health care professionals.
O Crime de Estupro de Vulnerável e o Estatuto da Pessoa com Deficiência
Authors: Silva Jessé Roberto Matos da , Silva Edson Oliveira da , Oliveira José Roniel Morais
Published: January 2024

O presente trabalho busca discutir as disposições do artigo 217-A, § 1º, do Código Penal frente ao Estatuto da Pessoa com Deficiência (Lei n. 13.146/2015), especificamente no que concerne a liberdade do deficiente mental para manter relações sexuais. À luz do método de abordagem dedutivo e do procedimento de pesquisa documental bibliográfica, realizou-se uma análise sistemática das disposições legais mencionadas, a fim de demonstrar que o conflito entre as normas é apenas aparente e que o Estatuto da Pessoa com Deficiência em nada interfere na caracterização do crime de estupro de vulnerável, sendo necessário, na verdade, apurar, em cada caso, se a enfermidade ou a deficiência mental de que padeça determinado indivíduo ocasiona a falta de discernimento para consentir com a prática do ato sexual. Destaca-se, ainda, ao longo de todo trabalho, que a liberdade sexual é um dos direitos da personalidade e é uma das vertentes do Princípio da Dignidade Humana.
Breves Reflexões acerca de Boas Práticas na Construção de uma Sociedade mais Sustentável
Authors: Pedreira-Oliveira Andréa Martins , Oliveira Luís Cláudio Pereira de
Published: January 2024

Em um mundo cada vez mais degradado e com ameaças reais à sobrevivência humana, faz-se necessário implementar boas práticas que promovam o desenvolvimento saudável e sustentável de pessoas e ambientes. O presente artigo tem por objetivo promover reflexão acerca de duas iniciativas a nível global para a construção de uma sociedade mais sustentável: o URBAN95 que se preocupa com os ambientes saudáveis para bebês, crianças pequenas e cuidadoras.res e a Green School Bali que responde aos desafios locais e às perspectivas globais alinhados aos parâmetros da Educação para o Desenvolvimento Sustentável (EDS). Relativamente à metodologia, foi realizada pesquisa em diferentes motores de busca, sites e livros para alcançar o objetivo proposto. Conclui-se que investir no potencial humano desde a primeira infância e dar continuidade durante toda a vida através de uma educação integral e holística, parece ser uma forma viável e inovadora de contruir ecossistemas sustentáveis.
Aplicação da Metodologia Ativa "Rotação por Estações" como Ferramenta Pedagógica nas aulas de Língua Inglesa
Authors: Nascimento Maria das Dores Silva , Ferreira Cicera Rosimere
Published: January 2024

A presente pesquisa tem como objetivo geral discutir como a aplicação da metodologia ativa “Rotação por estação “pode ser usada como ferramenta pedagógica nas aulas de língua inglesa. O modelo de ensino híbrido se assemelha ao que conhecemos como ensino tradicional, haja vista que se trata de uma junção de métodos vigentes a fazeres pedagógicos atuais. Por isso, não há necessidade de mudar todas as convenções do modelo de instrução que todos conhecem. Uma das vantagens desta ferramenta é que os professores estão mais presentes, garantindo o apoio aos alunos que necessitam de mais atenção, pois nem todos se desenvolvem ou aprendem da mesma forma. As tarefas executadas por cada estação são um tanto independentes, mas são realizadas de forma integrada. O objetivo desta proposta é promover a proficiência na língua inglesa e apresentar os conceitos, possibilidades e limitações da aplicação do método de rotação por estações como ferramenta de ensino na sala de aula de inglês durante o processo de ensino. Com aspectos teórico-metodológicos da pesquisa bibliográfica, utilizamos a pesquisa qualitativa, abrangendo alguns teóricos, entre eles estão: Berbel (2015), Freire (2017), Moran (2016), Moreira (2015), Mininel (2022) e demais pesquisadores, educadores e profissionais que atuam e defendem a melhoria do ensino de língua inglesa através de metodologias ativas de rotação por estação. As abordagens ativas melhoram a aprendizagem através da comunicação, interação e compreensão da realidade. Portanto, a combinação de tecnologias digitais e abordagens proativas podem levar a uma experiência diferenciada, possibilitando trabalhar com conteúdos complexos de forma colaborativa. O estudo constatou que, além das dificuldades encontradas durante a experiência, são necessárias ações inovadoras para tornar os alunos protagonistas da construção do conhecimento e estimular a vitalidade. A interação e a colaboração nos espaços de aprendizagem facilitam a formação integral do indivíduo.
A Importância dos Toantes Sagrados como Ludicidade na Perspectiva da Educação Escolar Infantil Indígena
Authors: Oliveira Geovana de Souza , Oliveira Débora Benício Alves de , Bringel Maricélia Félix Andrade
Published: January 2024

O presente trabalho trata de uma pesquisa bastante aprofundada sobre o tema: A importância dos Toantes sagrados como lúdico na perspectiva da Educação Infantil nas escolas indígenas. Este é um tema voltado para a compreensão de como ocorrem as metodologias e práticas pedagógicas através dos Toantes indígenas dentro da sala de aula. Sabemos que a cultura indígena é bastante diversificada as práticas culturais dos povos indígenas é bastante diversificada carregam significados místicos que selam a união da Aldeia e de seus povos. Dentre as práticas culturais existe a dança do coco, a dança da palma, a dança do toré dentre outras.  Todas essas manifestações são acompanhadas dos tons a qual eles caracterizam como Toantes/ e ou Rituais sagrado.  O estudo tem como objetivo investigar as práticas metodológicas de professores em relação aos toantes indígena como forma de ludicidade para alfabetizar crianças, visto que a musicalidade como ferramenta lúdica para a alfabetização infantil é uma das melhores estratégias como prática pedagógica para estabelecer o que está sendo trabalhado de forma descontraída. Contudo, pouco se fala sobre esta metodologia em termos de toantes sagrados indígenas dentro de suas respectivas escolas, ou se ela realmente existe em termos de alfabetização entre as crianças indígenas. As bases legais que constituem a educação escolar indígena são permeadas pela Constituição Federal de 1988, Lei de Diretrizes e Bases da Educação Nacional, resolução de 1999 e Decreto Presidencial de 2004, esse processo legislativo teve como objetivo assegurar e garantir o direito à diferença étnica, ou seja, ensinar os Curumins (crianças) a ler e escrever por meio de toantes sagrados é um método diferenciado que afirma suas identidades, resgata sua cultura e também gera aprendizado.
A Educação Geográfica no Ensino Fundamental I: Um Estudo de Caso em uma Escola Pública de Salgueiro-PE
Authors: Bezerra Edivânia Francisca , Bringel Maricélia Félix Andrade
Published: January 2024

Trata-se de um estudo de caso que abordou a importância do ensino de Geografia no Ensino Fundamental I, explorando seu papel na formação dos estudantes em relação à compreensão e interação com o mundo. Destacou-se a necessidade de despertar nos alunos a percepção de que a Geografia trata da realidade do espaço em que estão inseridos, incentivando-os a compreender concretamente a composição desse ambiente e a situar-se nele conscientemente, adotando atitudes e posturas cidadãs. O objetivo principal foi discutir a relevância do ensino da disciplina de Geografia para os estudantes do Ensino Fundamental I, focalizando a construção do conhecimento, a concepção de currículo e as práticas pedagógicas adequadas no processo de ensino-aprendizagem. Além disso, enfatizou-se o emprego da tecnologia como ponto crucial para uma aprendizagem abrangente, acreditando que, por meio dessa ferramenta, é possível proporcionar significado a todas as habilidades de aprendizagem necessárias para os estudantes nessa faixa etária. A pesquisa, classificou-se como descritiva devido aos objetivos, envolvendo o levantamento de características conhecidas dos fatos/fenômenos/problemas. Em relação aos procedimentos e coleta de dados, classificou-se como bibliográfica pois houve uma pesquisa sobre a temática onde buscou informações sobre a temática para isso teve se como referência Base Nacional Comum Curricular, Carneiro (2018), Cavalcante (2012), Ferreira (2019), Lima (2021), Moura (2022), entre ouros autores que contribuíram para a construção do artigo. A análise dos dados evidenciou que um ensino apropriado da disciplina de Geografia possibilita aos estudantes construir aprendizados e descobertas a partir da compreensão do lugar e do espaço, permitindo assim uma compreensão mais ampla do mundo.
Awareness about the Importance of Nutrition During Pregnancy Among Women in Child Bearing Age: A Quantitative Study Among Urban Women.
Authors: Khan Kayamkani Abedulla , Salem Maaly , Mohammed Rawan , Ahmad Raghad , Abdulkarim Ola , Mohammed Tasneem , Iqubal S. M. Shakeel , Khan Aejaz Abdullatif , Dawoud Areej , Maqbul Muazzam Sheriff , Mayana Noorulla Khan , Mubashira Begum Shaik
Published: January 2024

Introduction
An adequate nutrition pattern is of major importance for one’s health and well-being, especially during pregnancy when a woman undergoes major biological, physical, psychological and social transformations. Macronutrient and micronutrient deficiencies predispose the fetus to preterm birth, neural tube defects, and low birth weight for gestational age. This study was conducted to determine the nutrition awareness of women in childbearing age in order to provide a greater understanding of the life course perspective (LCP) in relation to nutrition behaviors and pregnancy.

Methods
A cross-sectional study was conducted on based on our conceptualization of nutrition awareness and questionnaire based studies of a face-to-face interview. The participants were women with age group of 17 years to 45 years participate in studies in Jeddah city. Data collection procedures A Semi-structured questionnaires prepared in English language were translated in to Arabic and then translated back to English to check for consistency. The questionnaires were pretested Human ethical committee; the questions assessed respondents’ nutrition knowledge.

Results and discussion
Different questions were asked to 175 selected pregnant women to be included in this study assess knowledge of pregnant mothers on nutrition and determinant factors in the study area. Most of the respondents (34.85.2%) were in 19-25 years of age group.69.1 % (n=121) women says they pay attention to the number of soft drinks they drink each day. There would be fascinating to study awareness of specific nutrients and related issues, like consumption folic acid, non-vegetarian diet, minerals and life style such as mental stress and physical exercise.
Glucose metabolism disorders associated with COVID-19: clinical and morphological study
Authors: Karonova T. L. , Mikhailova A. A. , Lagutina D. I. , Vorobeva O. M. , Grigoreva D. O. , Sterkhova K. A. , Malko V. A. , Mikheeva A. G. , Chernikova A. T. , Mitrofanova L. B. , Shlyakhto E. V.
Published: January 2024

BACKGROUND. Glucose metabolism disorders (GMD) were detected both in acute and in post-COVID, however, its pathogenic aspects remain unclear.

AIM. To analyze the occurrence of GMD in post-COVID patients who have had moderate and severe COVID-19 without previously known GMD disorders, and evaluate expression of SARS-CoV-2 proteins and its entry factors in pancreas in acute COVID-19.

METHODS. Among 187 hospitalized patients with confirmed COVID-19 141 patients without previously diagnosed GMD underwent follow-up post-COVID visits. The examination for all patients included anthropometric measurement with calculation of BMI, level of HbA1c and fasting plasma glucose, for 106 patients level of insulin and HOMA-IR index was analyzed. For histological examination, pancreas fragments of 20 patients with fatal outcome were selected. Immunohistochemical study was performed with antibodies to SARS-CoV-2, ACE2, DPP4, as well as double-labeled immunofluorescence microscopy (insulin-SARS-CoV-2, insulin-ACE2, insulin-DPP4).

RESULTS. Among 141 patients in post-COVID period, 9 (6.3%) had HbA1c or fasting plasma glucose levels that met criteria for diabetes mellitus, 38 (26.9%) — exceeded normal values (WHO), and 84 (59.6%) had GMD according to criteria of the ADA. In post-COVID, patients with GMD had a higher BMI and HOMA-IR index (p=0.001) compared to patients with normal glycemic levels. Only 40.4% of people had HOMA-IR index above 2.7. Patients with GMD had higher level of CRP (p=0.007) and a maximum glucose level (p=0.019) in the acute period. Positive relationship was found between BMI and HOMA index both in acute (p<0.001; r=0.389) and post-COVID (p<0.001; r=0.412) periods, as well as the level of HbA1c in acute period (p=0.019, r=0.202) and in post-COVID (p=0.004, r=0.242).

Histological and immunohistochemical studies showed the expression of SARS-CoV-2 proteins in 1.85% [0–15.4] and 11.1% [5.3–14.8] cells of the Langerhans islets in patients who died on the second and third waves, respectively. The expression of ACE2 and DPP4 in the islets of Langerhans did not exceed 0.4% [0–1.7] and 0.5% [0–0.8] of cells, respectively. Double-labeled immunofluorescence microscopy showed co-localization of SARS-CoV-2, ACE2, DPP4 with insulin.

CONCLUSION. Post-COVID Glucose metabolism disorders may be explained by direct cytotoxic effect of SARS-COV-2, increased glucose toxicity and insulin resistance because of the acute infection and its complex therapy.
Overview of modern sensors for continuous glucose monitoring
Authors: Momynaliev K. T. , Prokopiev M. V. , Ivanov I. V.
Published: January 2024

The incidence of diabetes is increasing in all age groups. The use of technological devices for the treatment of diabetes, such as continuous glucose monitoring (CGM), is expanding and is associated with improved control of blood glucose levels in order to prevent complications of this disease. Reducing glycemic variability and maintaining optimal glycemic control is critical to the management of patients with type 1 diabetes. The usefulness of glycemic monitoring devices has also been shown for patients with type 2 diabetes. CGM technology is constantly being improved in terms of analytical performance, biocompatibility, wear duration, safety and clinical performance. However, commonly used minimally invasive CGMs do not measure blood glucose directly, but instead measure the glucose concentration in the interstitial fluid (IF), so changes in IF glucose occur with a delay of 5 to 15 minutes compared to blood glucose. In addition, the lifetime of minimally invasive CGM sensors is relatively short, up to 14 days. Therefore, the introduction into clinical practice of devices for non-invasive glucose measurement in people with diabetes, which overcome the above-mentioned limitations of minimally invasive CGM, will expand the possibilities of glucose monitoring among patients with diabetes. The purpose of this review was to present the technologies of CGM system sensors approved for medical use in Russia and other countries.
Metformin as an activator of AMP-activated protein kinase. Known and new mechanisms of action
Authors: Mkrtumyan A. M. , Markova T. N. , Ovchinnikova M. A. , Ivanova I. A. , Kuzmenko K. V.
Published: January 2024

Metformin, known in the medical community as the drug of first choice for type 2 diabetes mellitus, belongs to the group of biguanides and has proven to be an effective treatment in clinical practice. Our knowledge of the pharmacodynamic properties of metformin has long been limited to the following well-known mechanisms: a decrease in hyperglycemia due to an increase in peripheral insulin sensitivity, glucose utilization by cells, inhibition of hepatic gluconeogenesis, an increase in the capacity of all types of membrane glucose transporters, activation of fibrinolysis, and a decrease in the levels of atherogenic lipoproteins. Recent studies show that the range of positive pleiotropic effects of metformin is not limited to the above, and that the molecular mechanisms of its action are more complex than previously thought. This article presents a less known, but equally important action of metformin, in particular, its anti-oncogenic, antiviral, and anti-aging effects. In our study, we highlight that the activation of 5’-adenosine monophosphate-activated protein kinase (AMPK) should be considered as the primary mechanism of action through which almost all beneficial effects are achieved. In the light of recent scientific advances in metformin pharmacology, together with the pathogenetic uncertainty of the term «biguanide», it seems fair and reasonable to apply a more relevant definition to the drugn, namely «AMPK activator».
FIDELIO study: significance and place of finerenone as nonsteroidal mineralocorticoid receptor antagonist in therapy of patients with chronic kidney disease in type 2 diabetes
Authors: Shamkhalova M. S. , Sukhareva O. Yu. , Yevloyeva M. I.
Published: January 2024

Patients with diabetes mellitus and renal pathology are at high risk of developing end-stage kidney disease (ESKD) and cardiovascular disease (CVD), including atrial fibrillation as an life-threatening condition. The intense annual increase in patients with diabetes mellitus, mainly due to the patients with type 2 diabetes mellitus (T2D), and diabetic nephropathy sets a new goal for researchers to expand the range of drugs with cardio- and nephroprotective effects to offset the residual risks of development and progression of chronic kidney disease (CKD) and CVD in this cohort of patients. One of such drugs is finerenone — a novel selective non-steroidal mineralocorticoid receptor (MR) antagonist (MRA), hyperactivation of which mediates renal inflammation and fibrosis, cardiac remodeling and changes in its structural and electrical characteristics. This review presents the results of the sub-analysis of FIDELIO devoted to the mechanism of drug action, the finerenone efficacy evaluation, its comparison with the efficacy of sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists with already proven organoprotective properties with respect to reducing the risk of renal and cardiovascular endpoints.
Natural Determinants of the Earth-Mound Fields Distribution in the Southwest of the State of Goiás
Authors: Malheiro Amanda Morais , Boeira Veronica Natalia , Bueno Guilherme Taitson , Mantovani José Roberto
Published: January 2024

Murundusfields, also known as covoais,are frequent microreliefs in the Cerrado. These are sets of semicircular elevations that protrude from the surface of the land, rounded or oval, with average dimensions of 70 cm in height and 6 m in diameter. The determinants of its regional spatial distribution are still poorly known. This study aimed to identify the natural determinants of its spatial distribution in the Southwest of Goiás, in the Sedimentary Basin of Paraná. All occurrences of murundusfields identified by the project Mapping of Remnant MurundusFields in the state of Goiás (SEMAD-GO/LAPIG-UFG) were compared with information referring to lithology, geomorphology,NDWI (Normalized Difference Water Index), and SMI (Soil Moisture Index). The indices were obtained from SENTINEL 2-A (MSI) and Landsat 8 (OLI and TIRS) orbital images. It was found that murundusfields preferentially occur in the Alluvial Deposits, Cachoeirinha, Detritic-lateritic Covers, and Serra Geral geological units. Murundusfields predominate under slopes of 0 to 8% (flat to gently undulating relief), and in areas with lower drainage density. The NDWI and the SMI indicated that murundusfields are concentrated on wet surfaces, occurring less frequently in saturated/very wet areas and in moderate humidity, dry, and very dry surfaces.
Identification of Gold Mining Vessels based on Classification Algorithms using Sentinel-2 Images
Authors: Pereira Diego Henrique Costa , Gomes Roberto Arnaldo Trancoso , Carvalho Júnior Osmar Abílio de , Guimarães Renato Fontes
Published: January 2024

Artisanal and small-scale gold mining can occur on land or in riverbeds. However, the activity needs to be supported by a Mining Permit, issued by the Agência Nacional de Mineração, and the appropriate environmental license from the competent environmental agency. The use of images from Sentinel-2 satellites presents itself as a potential tool for identifying gold mining vessels due to the temporal resolution, free imagery, global coverage, and more refined spatial resolution. So, this study aimed to identify gold mining vessels on the Madeira River near Porto Velho city, Rondônia state, located at Brazilian Amazon, in 13 Sentinel-2 images from 2018 to 2021 using the classifiers: Support Vector Machine (SVM), K-Nearest Neighbors (KNN) Random Forest (RF) and Spectral Angle Mapper (SAM). The results showed that machine learning classifiers obtained the best performance, especially the object-oriented SVM classifier, which had the best average F1 score (0.91).  In addition, the detection percentage of gold mining vessels originated by this classifier was satisfactory, with only 0 to 4 active gold mining vessels with sediment plumes being omitted per image. Therefore, based on the results obtained, it was concluded that the use of machine learning classifiers proved to be effective in identifying gold mining vessels.
TSG-6 Induces Apoptosis of Human Hypertrophic Scar Fibroblasts via Activation of the Fas/FasL Signalling Pathway
Authors: Li X.-Y. , Li T. , Li Xiao-Jing , Wang J.-N. , Chen Z.
Published: January 2024

Tumour necrosis factor-stimulated gene 6 (TSG6) is a protective inflammatory reaction gene which is upregulated by inflammatory processes. Recent studies suggest that TSG-6 exhibits anti-scarring effects. However, the mechanism of TSG-6 action in the scar formation remains poorly understood. We investigated whether TSG-6 affects growth of the human hypertrophic scar fibroblasts (HSFs) via Fas/FasL signalling pathway. Cultured HSFs were transfected with a vector carrying the TSG6 gene (pLVX-Puro-TSG-6) or with a vector not containing the TSG6 gene (pLVX-Puro). Untransfected HSFs served as a control group to both transfected HSFs. The expressions level of TSG-6 was up-regulated in the pLVX-Puro-TSG-6 group at the protein and mRNA level. MTT and flow cytometry were used to assess the effect of TSG-6 on the growth and apoptotic status of HSFs. Finally, qRT-PCR and western blot were used to measure the expression levels of Fas, FasL, FADD, caspase-3 and caspase-8 in each group. The apoptosis rate was significantly enhanced and the growth rate reduced in the HSFs transfected with the TSG6 gene vector. The expression levels of Fas, FasL, FADD, caspase-3 and caspase- 8 were significantly raised in the TSG-6 overexpressing HSFs. It is concluded that increased expression of TSG-6 may induce apoptosis of human hypertrophic scar fibroblasts via activation of the Fas/FasL signalling pathway.
O tym jak się „dusza narodu na wzór ojczystych okolic nastraja”. Ideologiczny krajobraz ojczyzny w serbskim dyskursie urbanistycznym okresu międzywojennego
Authors: Nowak-Bajcar Sylwia Nowak-Bajcar
Published: January 2024

Kiedy pod koniec lat sześćdziesiątych XIX wieku powstał projekt kompleksowej modernizacji stolicy Serbii - Belgradu, stałym elementem większości dyskusji poświęconych temu problemowi była altruistyczna troska o zdrowie społeczeństwa. Dyskurs zdrowotny, oprócz estetycznego był elementem łączącym refleksję nad miastem na Zachodzie Europy i w Serbii. Jednak o ile na Zachodzie próby uzdrowienia przestrzeni miejskiej stanowić miały antidotum na negatywne skutki industrializacji, w odniesieniu do Belgradu zabiegi te wynikały z przesłanek zupełnie innych, motywowane były mianowicie spuścizną po czasach przemysłowego zacofania jako pokłosia panowania tureckiego. Szczególna rola w procesie modernizowania Belgradu przypadła terenom zieleni miejskiej. Troska o nie w wypowiedziach serbskich architektów i urbanistów okresu międzywojennego przedstawiana jako probierz nowoczesności włączona została w istocie w misję umacniania interesów dynastycznych, opartą na „leśnym mitotwórstwie narodowym”. W artykule prezentuję mechanizmy projektowania na przyrodę filtru historycznego i politycznego w celu jej włączenia w procesy stwarzania i umacniania ideologii „integralnego jugoslawizmu”.
Żywot świętej Paraskewy-Petki Tyrnowskiej w Damaskinie Berlińskim. Aspekt genealogiczny i tematyczny
Authors: Kuczyńska Marzanna
Published: January 2024

Przedmiotem zainteresowania w artykule jest XVIII-wieczna nowobułgarska wersja żywota świętej Paraskiewy-Petki Tyrnowskiej autorstwa bułgarskiego patriarchy Eutymiusza (XIV w.), zamieszczona w słabo zbadanym damaskinie berlińskim przechowywanym obecnie w Bibliotece Jagiellońskiej w Krakowie (tzw. kolekcja berlińska) pod sygnaturą Berol. Ms. Slav. Fol. 36; karty 180–187r. Analiza dotyczy aspektu genologicznego i tematycznego utworu w kontekście twórczości damaskinarskiej wieków XVI – XVIII. Główna uwaga skupia się na zawartości tekstu, transformacji retoryczno-stylistycznej (redukcja, obniżenie stylu) oryginału i nowych komponentach. Za najciekawszy element struktury uznano dodatki tekstologiczne związane z wędrówką relikwii Paraskiewy z Bułgarii przez Serbię do Grecji i Mołdawii, które pozwalają zaliczyć krakowski wariant żywota do mołdawskiej redakcji hagiograficznej.
Higher-order circular intuitionistic fuzzy time series forecasting methodology: Application of stock change index
Authors: Ashraf Shahzaib , Sohail Muhammad , Chohan Muhammad Shakir , Paokanta Siriluk , Park Choonkil
Published: January 2024

This article presents a higher-order circular intuitionistic fuzzy time series forecasting method for predicting the stock change index, which is shown to be an improvement over traditional time series forecasting methods. The method is based on the principles of circular intuitionistic fuzzy set theory. It uses both positive and negative membership values and a circular radius to handle uncertainty and imprecision in the data. The circularity of the time series is also taken into consideration, leading to more accurate and robust forecasts. The higher-order forecasting capability of this method provides more comprehensive predictions compared to previous methods. One of the key challenges we face when using the amount featured as a case study in our article to project the future value of ratings is the influence of the stock market index. Through rigorous experiments and comparison with traditional time series forecasting methods, the results of the study demonstrate that the proposed higher-order circular intuitionistic fuzzy time series forecasting method is a superior approach for predicting the stock change index.
A Knife in the Heart or a Sword in the Courtroom: The Benefits and Drawbacks of Empathy in the Legal Field
Authors: Long Anna Rose
Published: January 2024

The English word “empathy” originally comes from the German word “Einfühlung,” which translates to “feeling into.” As defined by Merriam Webster, empathy is the action of understanding, being aware of, being sensitive to, and vicariously experiencing feelings, thoughts, and experiences fully communicated in an objectively explicit manner. Often, the terms “sympathy” and “empathy” are used interchangeably. However, the two terms do have distinct meanings. Sympathy refers to the feeling of care and sharing of another’s difficulties, whereas empathy refers to placing yourself in someone else’s position and understanding that person’s point of view. In doing this, the empathetic person experiences the feelings of another. To an attorney, empathy provides numerous aids but also may contribute to several downfalls in the legal profession. This Comment will examine the impact of empathy on legal practitioners, assessing its influence on both compliance with legal standards and the mental well-being of attorneys.
Right and left inverse scattering problems formulations for the Zakharov–Shabat system
Authors: Chernyavsky Alexander E. , Frumin Leonid L. , Gelash Andrey A.
Published: January 2024

We consider right and left formulations of the inverse scattering problem for the Zakharov–Shabat system and the corresponding integral Gelfand–Levitan–Marchenko equations. Both formulations are helpful for numerical solving of the inverse scattering problem, which we perform using the previously developed Toeplitz Inner Bordering (TIB) algorithm. First, we establish general relations between the right and left scattering coefficients. Then we propose an auxiliary kernel of the left Gelfand–Levitan–Marchenko equations, which allows one to solve the right scattering problem numerically. We generalize the TIB algorithm, initially proposed in the left formulation, to the right scattering problem case with the obtained formulas. The test runs of the TIB algorithm illustrate our results reconstructing the various non-symmetrical potentials from their right scattering data.
The effects of osteopathic manipulative treatment on pain and disability in patients with chronic low back pain: a single-blinded randomized controlled trial
Authors: Popovich John M. , Cholewicki Jacek , Reeves N. Peter , DeStefano Lisa A. , Rowan Jacob J. , Francisco Timothy J. , Prokop Lawrence L. , Zatkin Mathew A. , Lee Angela S. , Sikorskii Alla , Pathak Pramod K. , Choi Jongeun , Radcliffe Clark J. , Ramadan Ahmed
Published: January 2024

Context

The evidence for the efficacy of osteopathic manipulative treatment (OMT) in the management of low back pain (LBP) is considered weak by systematic reviews, because it is generally based on low-quality studies. Consequently, there is a need for more randomized controlled trials (RCTs) with a low risk of bias.

Objectives

The objective of this study is to evaluate the efficacy of an OMT intervention for reducing pain and disability in patients with chronic LBP.

Methods

A single-blinded, crossover, RCT was conducted at a university-based health system. Participants were adults, 21–65 years old, with nonspecific LBP. Eligible participants (n=80) were randomized to two trial arms: an immediate OMT intervention group and a delayed OMT (waiting period) group. The intervention consisted of three to four OMT sessions over 4–6 weeks, after which the participants switched (crossed-over) groups. The primary clinical outcomes were average pain, current pain, Patient-Reported Outcomes Measurement Information System (PROMIS) 29 v1.0 pain interference and physical function, and modified Oswestry Disability Index (ODI). Secondary outcomes included the remaining PROMIS health domains and the Fear Avoidance Beliefs Questionnaire (FABQ). These measures were taken at baseline (T0), after one OMT session (T1), at the crossover point (T2), and at the end of the trial (T3). Due to the carryover effects of OMT intervention, only the outcomes obtained prior to T2 were evaluated utilizing mixed-effects models and after adjusting for baseline values.

Results

Totals of 35 and 36 participants with chronic LBP were available for the analysis at T1 in the immediate OMT and waiting period groups, respectively, whereas 31 and 33 participants were available for the analysis at T2 in the immediate OMT and waiting period groups, respectively. After one session of OMT (T1), the analysis showed a significant reduction in the secondary outcomes of sleep disturbance and anxiety compared to the waiting period group. Following the entire intervention period (T2), the immediate OMT group demonstrated a significantly better average pain outcome. The effect size was a 0.8 standard deviation (SD), rendering the reduction in pain clinically significant. Further, the improvement in anxiety remained statistically significant. No study-related serious adverse events (AEs) were reported.

Conclusions

OMT intervention is safe and effective in reducing pain along with improving sleep and anxiety profiles in patients with chronic LBP.
The prognostic role of CRL discordance in first trimester ultrasound
Authors: Fasoulakis Zacharias , Sapantzoglou Kimonas , Theodora Marianna , Daskalakis George , Kurjak Asim , Antsaklis Panagiotis
Published: January 2024

Objectives

In the first trimester, intertwin crown-rump length (CRL) discordance has emerged as a notable factor linked to adverse perinatal health effects. It is frequently employed as a basis for counseling parents regarding potential adverse pregnancy outcomes. Despite its established association with adverse outcomes, the significance of CRL discordance in substantially predicting pregnancy problems and its efficacy in pregnancy screening remain subjects of ongoing discussion. The aim of this manuscript is to present current knowledge on CRL discordance.

Methods

PubMed was searched for related articles with terms “Crown-Rump length”, “Prenatal Screening”, “Twin pregnancy”, “Discordance”.

Results

Twenty-two studies were included in our study with six reporting data on monochorionic and 16 assessing the correlation between CRL discordance and adverse pregnancy outcomes. Fetal loss at the 20th and 24th week of the pregnancy, SGA neonates, pre-term delivery (32 weeks), perinatal death (24 weeks) are all reported adverse outcomes associated with CRL discordance. The reported cut-off for increased risk of adverse perinatal outcomes is a discordance of at least 10% or more.

Conclusions

Increased CRL (>10 %) discordance is linked to a higher risk of sFGR in both monochorionic and dichorionic pregnancies, fetal loss, and preterm delivery.
A multiplicative approach to decathlon scoring based on efficient frontiers
Authors: Schütz Manuel , Tofallis Chris
Published: January 2024

The decathlon consists of ten events with scores which are then aggregated to determine the final ranking. We develop a decathlon scoring method which is far simpler than the existing standard (IAAF1984) tables, as there are only 9 parameters instead of 30 which have an impact on the overall rank. We first identify athletes who are on the Pareto-efficient frontier i.e. those who are not dominated by anyone else. We then remove these frontier athletes and again pick all non-dominated athletes to obtain a second dominating group/Pareto frontier and iterate this procedure for the decathlon data from 1986 to 2020. Each of these groups are then characterized by their set of ten median performances. Improving from the last to the top group can then be seen as a path of progress, leading from the lowest to the highest set of median performances. Every event should have the same importance, so we normalize the data such that the path of progress follows as much as possible a space diagonal of a ten dimensional hypercube. Furthermore, any adjustment of a benchmark does not change any actual decathlon performance, hence there cannot be any unwanted rank reversals. This allows a smooth adjustment of these tables in the future, if for instance a new type of javelin needs to be introduced to reduce the range. We normalize such that current performances between 7000 and 9000 points still fall into the same range with our point tables.
Sculpting ultrastrong light–matter coupling through spatial matter structuring
Authors: Mornhinweg Joshua , Diebel Laura , Halbhuber Maike , Riepl Josef , Cortese Erika , De Liberato Simone , Bougeard Dominique , Huber Rupert , Lange Christoph
Published: January 2024

The central theme of cavity quantum electrodynamics is the coupling of a single optical mode with a single matter excitation, leading to a doublet of cavity polaritons which govern the optical properties of the coupled structure. Especially in the ultrastrong coupling regime, where the ratio of the vacuum Rabi frequency and the quasi-resonant carrier frequency of light, ΩR/ω
c, approaches unity, the polariton doublet bridges a large spectral bandwidth 2ΩR, and further interactions with off-resonant light and matter modes may occur. The resulting multi-mode coupling has recently attracted attention owing to the additional degrees of freedom for designing light–matter coupled resonances, despite added complexity. Here, we experimentally implement a novel strategy to sculpt ultrastrong multi-mode coupling by tailoring the spatial overlap of multiple modes of planar metallic THz resonators and the cyclotron resonances of Landau-quantized two-dimensional electrons, on subwavelength scales. We show that similarly to the selection rules of classical optics, this allows us to suppress or enhance certain coupling pathways and to control the number of light–matter coupled modes, their octave-spanning frequency spectra, and their response to magnetic tuning. This offers novel pathways for controlling dissipation, tailoring quantum light sources, nonlinearities, correlations as well as entanglement in quantum information processing.
The physicochemical and DNA binding studies of ceftazidime pentahydrate and cefotaxime sodium in aqueous medium
Authors: Khan Abbas , Khan Sher Shah , Rahman Ubaid Ur , Bououdina Mohamed , Humayun Muhammad , Shah Nasrullah , Rehman Noor
Published: January 2024

Ceftazidime pentahydrate (CP) and cefotaxime sodium (CS) are semisynthetic cephalosporin antibiotics and are used to treat a variety of diseases worldwide. In order to explore the efficiency of a medicinal compound, it is important to have a deep understanding of its solution and physiochemical behaviour along with its interaction with biological molecules. In this regard, the solution of two drugs i.e., ceftazidime pentahydrate (CP) and cefotaxime sodium (CS) were investigated in detail. The physicochemical properties of drugs solutions and their interaction with deoxyribonucleic acid (DNA) were studied in water under varying experimental parameters. In the present study the physicochemical properties such as density, viscosity, surface tension, and conductance of aqueous solution, having various molar concentrations, of CP and CS were traced out at different temperatures. Five various concentrations (0.05, 0.1, 0.15, 0.2, and 0.3 mol dm−3) of each drug in an aqueous medium were prepared separately, and the physicochemical properties of each solution, were studied individually at temperatures such as 293, 303, 313, 323, and 333 K respectively. Most of these parameters have shown different behaviour with varying concentration of solution and temperature of the medium. In addition, these drugs showed a spontaneous surface-active and association behaviour in aqueous solutions and drug DNA solution. The flow behaviour, surface properties, volumetric behaviour and solute–solvent interaction of this drug were prominently influenced by experimental variables. UV-Visible spectroscopy was also used to study the interaction of these drugs with DNA in aqueous media in detail. Calculated values of binding constants (K
b) for all drug–DNA are positive, indicating constructive binding and interactions between the molecules. In addition the binding efficiency of ceftazidime pentahydrate was found more than that of cefotaxime sodium. The interaction of drug–DNA was not only affected by the nature of the drug but also by the drug-to-DNA ratio and nature of the medium used.
Közegészségügy a figurációs szociológia tükrében – egy elméleti kísérlet
Authors: Kurucz Barnabás
Published: January 2024

Jelen tanulmányomban arra teszek kísérletet, hogy a figurációs szociológia segítségével elemezzem a közegészségügy alakulását a Horthy-korszak első felében. A fogalmi keretekből fakadóan elsődlegesen a Magyar Királyi Népjóléti és Munkaügyi Minisztérium látószögéből teszem mindezt, így az állam alatti alakzatok egyelőre nem képezik részét vizsgálódásaimnak. Célom, hogy ezzel a tanulmánnyal tegyem meg az első lépést ahhoz, hogy a szociálpolitikatörténet a figurációs szociológia elemzési tárgyává váljon. A tanulmány levéltári és szakirodalmi anyagok révén felvezetést kíván alkotni egy történeti szociológia modellhez. Norbert Elias munkássága szolgáltatja az elméleti kiindulópontot, miszerint az emberiség egy pluriverzum, szociológiailag túlélési egységekre bomlik, melyek egymás ellenében szerveződnek meg. Ezek a figurációk támadó- és védekező funkciókkal bírnak, melyek a túlélési egység magasabb integrációjával együtt bővülnek. Ezáltal fokozódik szociális gondoskodás igénye, ami állami feladattá nőtte ki magát az első világháborút követően. A kórházi infrastruktúra bővítése, vagy a közegészségügy állami szervezése ezért kulcsfontosságú a belső béke és a lakosság teljesítőképességének megőrzésének szempontjából. Azonban a túlélési egységek ideológiai funkcióval is bírnak, ezáltal legitimálva uralmukat, jelölve ki céljaikat és eszközeiket. A tanulmány elméleti haszna a figurációs szociológia, valamint a nyugaton újraéledő történeti szociológia hazai népszerűsítése; gyakorlati haszna pedig a hazai vizsgálódások köréből kimaradt Magyar Királyi Népjóléti és Munkaügyi Minisztérium munkásságának vázlatos megismerése.
Metodología de cálculo y modelado de las necesidades térmicas en el proceso de producción de una destiladora de mezcal tradicional
Authors: Melchor Quintas Donaji , Carvajal-Mariscal Ignacio , Quinto Díez Pedro
Published: January 2024

En México, Oaxaca es uno de los estados que cuenta con denominación de origen para la fabricación de mezcal. Los métodos de producción de esta bebida pueden ser artesanal o industrial. Los fabricantes muestran interés para innovar en los sistemas tradicionales de producción de mezcal con la intención de eficientar procesos. En el presente trabajo se desarrolla una metodología que contempla un proceso que va desde la llegada de los agaves a la fábrica hasta la destilación. Para cada etapa de la producción de mezcal se realizó un balance de materia y energía, identificando las entradas y salidas para calcular la energía térmica involucrada en cada etapa. La metodología desarrollada se utilizó para modelar el proceso de producción usando un software comercial. A partir del análisis de resultados, se identificaron áreas de oportunidad donde se puede integrar la modernización de los procesos, enfocándose en el uso de fuentes alternas de energía y la conservación del medio ambiente.