bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlation of C3c complement, NT-pro BNP and Left Ventricle Ejection Fraction in Heart Failure
Authors: Julious Julious , Nugraha Jusak , Aminuddin Mohammad
Published: January 2020

Introduction. Heart failure is a health problem in Indonesia. The 2013 Basic Health Research Data showed that the estimated heart failure in Indonesia was 530,068 people. Echocardiography examination which has been a routine examination of heart failure patients is not necessarily available in all hospitals, so that a more applicable and inexpensive alternative examination is needed. Previous studies have shown an increase in C3c levels associated with improved survival and better cardiac remodeling. On this basis, this research needs to be performed in order to determine the correlation between C3c complement levels, NT-proBNP and LVEF in heart failure patients. Method. A cross-sectional study was conducted at the Dr Soetomo Hospital between August 2018 to September 2018 with 30 samples. Samples were taken consecutively from patients with heart failure who were treated at the integrated heart service center. Examination of C3c complement, NT-proBNP and echocardiography (LVEF data) was carried out in all patients. Result. The result of this study showed no significant correlation between C3c complement and NT-proBNP (r = -0.253, p = 0.177). The correlation between C3c complement and LVEF was also not significant (r = -0.074, p = 0.696). A significant moderate correlation between NT-proBNP and LVEF was found (r = -0.444, p = 0.014). Conclusion. The C3c complement could not be used as an alternative examination for NT-proBNP and LVEF. The limitations of the study were heterogeneous sample characteristics. A further study with more stringent criteria is needed to minimize the bias of examination results.
Evaluation of Immunochromatography Test Using Tp17 Antigen for Detection of Treponemal Antibody in Blood Donors
Authors: Rahayuningsih Dwi , Aryati Aryati , Arifah Budi
Published: January 2020

Syphilis transmission through blood transfusion urged WHO recommend examination of treponemal antibody in blood donors. Treponemal antibody was identified to be formed against the membrane of lipoprotein antigen Tp15, Tp17, and Tp47 of T.pallidum. Tp17 antigen may have important role in the pathogenesis of syphilis. Evaluation of CLIA method using Tp17 antigen showed a good diagnostic value. Currently immunochromatography test using Tp17 antigen was available but the diagnostic value has not been widely published. The aim of this study was to determine the diagnostic value of immunochromatography test using Tp17 antigen for treponemal antibody detection in blood donors. Total 100 serum samples with reactive (n=66) and non-reactive (n=34) treponemal antibody screened with ELISA and CLIA methods in blood transfusion unit of Surabaya, Mojokerto, and Sidoarjo Indonesian Red Cross from May 2018-August 2018 were examined for treponemal antibody with immunochromatography test using Tp17 antigen (StandardTM Q Syphilis Ab, Standard Biosensor) and Fluorescent Treponemal Antibody Absorption /FTA-ABS (EUROIMMUN, AG) as gold standard. Kappa Cohen analysis showed the concordance of immunochromatography test using Tp17 antigen was moderate and significant with IgG anti-treponemal FTA-ABS (k = 0.477 p: 0.000). The IgM anti-treponemal was non-reactive in all samples. The sensitivity was 69.8% with 81% of specificity. The sensitivity was not high may be due to the use of a single antigen (Tp17) while the treponemal antibody was formed by Tp15, Tp17, and Tp47 antigen predominantly, the others possbilities were decreased of IgG anti-Tp17 in donors after syphilis treatment, and differences of gold standard with other studies (FTA-ABS vs TPHA). Further study was needed with TPHA that was routinely used as a confirmation test, Western Blot to determine the antibody others than anti-Tp17, and non-treponemal test to determine the disease activity.
Vitamin D, Calcium and Phosphor in Patients with Î²-Thalassemia Major
Authors: Harahap Ade Hariza , Lubis Bidasari , Hariman Herman
Published: January 2020

There has been many reports that patients with Î²-thalassemia major have bone problems such as thinning of the bone, bone fragility and pathological fractures. For so many years it was believed that the bone problems is mainly caused by marrow expansion due to compenstation of the bone marrow to handle the chronic anaemia and hiypoxia in Î²-thalassemia major. Recently, there is evidence to suggest that in Î²-thalassemia major there is hypocalcemia and hypovitaminosis D. So, this study is to clarify if hypovitaminosis D is trully the cause of bone problem in thalassemia. Forty five subjects were recruited in this study, 35 were Î²-thalassemia major patients and 10 normal subjects as controls. Ten mL of venous blood were taken from median vein for investigations of total vitamin D [25(OH) vitamin D], total calcium and phosphor using the Enzyme-Linked Fluorescent Assay (ELFA), metallochromic dye (Arsenazo III) and chemical reaction of inorganic phosphate with amonium mollybdate respectily. Mean ± SD of vitamin D in Î²-thalassemia major is 21.28 ± 6.36 ng/ml and in control 34.85 ± 3.50 ng/ml (p<0.05); total calcium in Î²-thalassemia major is 8.58 ± 0.68 mg/dl and in control 9.22 ± 0.35 mg/dl (p<0.05); and phosphor in Î²-thalassemia major 3.98 ± 0.53 mg/dl and control  3.89 ± 0.49 mg/dl (p>0.1). There was no significant correlation (r = 0.17, p>0.05), when vitamin D was analysed against calcium for the correlation study,. This study demostrates that there was state of hypovitaminosis D and hypocalcemia in Î²-thalassemia major but hypovitaminosis D is not the only causative factor of the calcium levels. There should be another factor responsible for the calcium levels in Î²-thalassemia major and marrow expansion may remain the factors responsible for bone abnomarlities.
Detection of Bacteria Causes Ventilator Associated Pneumonia with Bronchoalveolar Lavage Culture and Endotracheal Aspirate Culture
Authors: Asty Hairiah , R Loesnihari , F Syarani
Published: January 2020

Ventilator associated pneumonia (VAP) is the most common hospital infection in ICU. Proper and prompt diagnosis and treatment with adequate antibiotics can reduce the high mortality rate, and prevent complications and antibiotic resistance. Invasive methods, such as bronchoalveolar lavage can make a more accurate diagnosis and help with the choice of antibiotics, but require lung experts. While non-invasive methods, such as endotracheal aspirate can be done faster with less complications. The aim of the study was to determine the pattern of bacterial and bacterial sensitivity to bronchoalveolar lavage and endotracheal fluid. This was an observational study with cross-sectional approaches performed at the Intensive Care Unit of RSUP H. Adam Malik Medan, in August 2017 - February 2018. The sample of  23 patients  who met the criteria and was suspected with VAP was carried out by taking endotracheal aspirate and bronchoalveolar lavage. The samples obtained were culture and sensitivity test using BD Phoenix. There was bacteria pattern had compatibility at moderate levels and there was sensitivity and antibiotic resistance were not significantly different from bronchoalveolar cultures and endotracheal aspirate cultures. Endotracheal aspirate culture has a sensitivity of 78.9% and a specificity of  75% for diagnose VAP. Information on the identification of bacteria and sensitivity testing in patients with suspected VAP is required using appropriate sampling techniques. There were no significant differences between bronchoalveolar lavage culture and endotracheal aspirate culture to diagnosing VAP. Endotracheal aspirate culture is a non invasive diagnostic tool that can be used as an alternative diagnostic tool in patients with suspected VAP.
Increased Insulin Like Growth Factor-1 and Antropometri in Premature Infants with Breast Milk
Authors: Sridharaswari I Dewa Ayu Agung , Irmawati Mira , Suryawan Ahmad , Idris Irwanto , Retnowati Endang
Published: January 2020

Massage stimulation has consistently led to greater anthropometric in preterm infant by increasing IGF-1 in which plays an important role in promoting growth by stimulating cell growth, multiplication and inhibiting apoptosis. This research to analyze the effect of massage stimulation on IGF-1 and anthropometric in breastfeeding preterm infant. A randomized control trial was conducted on preterm infant with gestational age less than 37 weeks between February – May 2018 in nursery Dr. Soetomo Hospital. Fifty infants in nursery was randomly assigned to massage stimulation or control group. Massage stimulation consisted for three, 15 minutes periods per day for 10 days. Insulin Growth Factor -1 serum was examined on day 1 and 10. Data were analyzed by statistical software using t-test and spearman correlation. The average increase of IGF -1  in massage group was 4.8 (SD 4.41) and 3.1 (SD 3.57) in control group. The average increase of body weight was 252.2 (SD 208.55) in massage group, and 137.9 (SD 69.78) in control group. The average increase of body length was 2 (0.68) in massage group, and 1.1 (0.33) in control group. The average increase of head circumference was 1.5 (SD 0.82) in massage group, and 0.9 (0.28) in control group. The positive correlation between the mean increase of IGF-1 and body length was 0.347. The conclusion was IGF-1 and anthropometric  increase in both groups, but the massage group has a significantly higher mean. An increase in IGF-1 correlates with increase in body length.
Correlation between Serum Ferritin and Heart Function in Children with Major Thalassemia at Dr. Soetomo Hospital
Authors: Frans Evisina Hanafiati , Rahman Mahrus A , Ontoseno Teddy , Ugrasena I Dewa Gede , Wahabe R Fatchul
Published: January 2020

Background: Cardiac hemosiderosis in major thalassemia has a high mortality rate. Serum ferritin levels are routinely performed to measure body iron deposit Early detection of cardiac dysfunction by routine echocardiography is very important to prevent complications due to hemosiderosis. Objective: To analyze correlation between serum ferritin levels and heart function in thalassemia major children. Methods: A cross-sectional study involving children of thalassemia major less than 18 years in the pediatric hematology oncology outpatient clinic at Dr. Soetomo Hospital. The subjects were children diagnosed with thalassemia major who had received more than 10 transfusions and had ferritin levels above 500 µg / L. All subjects were taken through consecutive sampling and performed echocardiography to measure right ventricular systolic function, left ventricular systolic function, and diastolic function. The factors analyzed included serum ferritin levels, TAPSE index, ejection fraction, and E / A ratio. Statistical analysis using chi square. Results: A total of 82 children were taken as the study sample that met the inclusion and exclusion criteria, 1 sample was dropped out due to pneumonia. Serum ferritin was not correlated to right ventricular systolic function (Cramer's phi constant 0.14, p = 0.209). Serum ferritin was not correlated with left heart systolic function (Cramer's phi constant 0.187, p = 0.09). Serum ferritin was not related to diastolic function (Cramer's phi constant 0.124, p = 0.264). Conclusion: Serum ferritin level in major thalassemia was not correlated with cardiac function
Differences of Bone Marrow Features and BCR-ABL Variants in Chronic Granulocytic Leukemia Post Tyrosine Kinase Inhibitor Therapy
Authors: Devi Wivina Riza , Prenggono M Darwin , AP Purwanto , B Imam
Published: January 2020

Chronic Granulocytic Leukemia (CGL) occurs due to chromosomal translocation (9;22) known as Philadelphiachromosome. p210 BCR-ABL1 oncogenes are classified into b2a2 and b3a2 transcripts which possibly lead to differentclinical manifestations and response to therapy. This study was aimed to prove that there is a difference in bone marrowfeatures and BCR-ABL between remissive and resistant CGL after Tyrosine Kinase Inhibitor (TKI) therapy. This research wasan observational study with a cross-sectional design carried out at Ulin Hospital Banjarmasin on 32 subjects. BCR ABL wasdetected by using PCR and bone marrow features were assessed by using bone marrow aspiration technique. The differencebetween bone marrow features and BCR-ABL variants was analyzed by using the T-test (p < 0.005) and Chi-Square(p < 0.005), respectively. There was a difference of BCR-ABL variants with p=0.091 and characterized by M:E ratio (p=0.124),myeloblast count (p=0.063), and eosinophil count (p=0.055). Also, there was a difference of bone marrow cellularity(p=0.000) and basophil count (p=0.016) between remissive CGL and resistant CGL patients. There was no difference in BCRABL variants, myeloblast count and eosinophil count between remissive CGL and resistant CGL patients. However, there wasdifferent of bone marrow cellularity and basophil count between remissive CGL and resistant CGL patients.
Variasi Genetik Mutan Anggrek Spathoglottis plicataBlume. Berdasarkan Marker ISSR
Authors: Romeida Atra , Sutjahjo Surjono Hadi , Purwito Agus , Sukma Dewi , Rustikawati ,
Published: January 2020

Mutants of Spathoglottis plicataBlume were obtained from plants treated with Gamma Irradiation at 30-100 Gray. The mutants showed variations in the flower morphology. The objective of this experiment was to identify genetic variations of orchids S. plicataand its mutants using inter-simple sequent repeat (ISSR) markers. The amplified product of 10 ISSR primers produced 360 bands and 71 ISSR of the loci (90.14%) were polymorphic. The coefficient of similarity and principal component analysis produced five major groups with similarity coefficient of 0.68. The goodness of fit correlation matrix value reached 0.91. Therefore the ISSR isa good marker for identification of S. plicatamutants.Keywords: gamma irradiation, ISSR marker, mutant, orchid
Penapisan Genotipe Jarak Pagar (Jatropha curcas L.) untuk Toleransi terhadap Kekeringan
Authors: Misnen , , Palupi Endah Retno , Syukur Muhamad , Yudiwanti ,
Published: January 2020

The selection of Jatropha curcasfor drought tolerance is one of the key points prior to growing the species extensively on marginal lands. The objective of this study was to determine drought tolerant genotypes based on morphological and physiological characters. The research consisted of two experiments. The first experiment was aimed at determining the moisture content of the media to generate drought stress. The experiment was arranged in a split-plot design with moisture content as the main plot and genotypes as sub-plot. Four level of moisture contents were tested, i.e. 22-23%, 27-28%, 32-33%, and 37-38%. The genotypes tested (9) were Dompu-1, Gunung Tambora, Bima (representing genotypes from dry areas); Aceh Besar, IP-2P, Komering (representing genotypes from wet areas); and IP-1M, Papua, Yogyakarta (representing genotypes from moderately dry areas). The result showed that 22-23% moisture content of the media was suitable for drought tolerance test in Jatropha curcas. The second experiment was screening of genotypes using the suitable media moisture content from first experiment. Twenty three genotypes were screened for drought tolerance under 22-23% media moisture content. The result show that Dompu-2, Indralaya and China were tolerant to drought; Sukabumi-1, Sukabumi-2, Pidi, Lahat, Kupang, Lampung-2, Lampung-3, Sumba, IP-2M, and IP-2A genotypes were moderately tolerant; Curup, Bogor-1, Bogor-2, Bogor-3, Pontianak, Pagar Alam, Palembang, Saweli, Jeneponto, and Medan genotypes were sensitive to drought. Plant height, leaf water content, leaf area and percentage of plant survival can be used as indicators of drought tolerance for seedling selection using a non-destructive method.Keywords: drought tolerance, genotypes, Jatropha curcas, screening
Success factors for data–driven service delivery networks
Authors: Pikkarainen Minna , Huhtala Tero , Kemppainen Laura , Häikiö Juha
Published: January 2020

Data is becoming a more and more important resource for future innovations. Companies are currently considering how to leverage personal data in preventive healthcare and in other sectors. However, there are many challenges hindering the development of data-driven businesses in extant business networks. The purpose of this paper is to explore the success factors of data-driven service delivery networks in the context of preventive healthcare. The results are examples of the benefits and challenges of data availability and usage, based on a qualitative case study, in which a network of actors is integrating resources to solve the needs of their end customers. The results underline the success factors for service delivery networks, creating a baseline for human-centric, personalized and preventive healthcare solutions. The study enriches the theoretical perspective of data, services and service delivery networks by continuing discussion on how big data resources become cooperative assets not only in a firm but also on the network level. This study has multiple implications for practitioners trying to navigate the turbulent waters of the changing business environment and evolving service delivery network of preventive healthcare. Especially small and medium size of firms could use the identified success factors when planning new data-driven services in their networks. Our analysis brings new perspective between a firm and the actors in its network, particularly in the preventive healthcare sector wherein data needs to be shared between actors via consent of the individuals.
Resources Capability of Government Co-operatives Supporting Organizations for Innovations Dissemination to Primary Co-operative Societies in Tanzania
Authors: Njau Luka S. , Mahonge Christopher P. , Massawe Fatihiya A.
Published: January 2020

This study assessed resources capability of government co-operative supporting organizations (GCSOs) in innovations dissemination to primary co-operative societies (PCSos) in Tanzania. Case study research design using multiple cases was used involving five cases. Primary data were collected using key informant interviews, focus groups discussions, documentary reviews and personal observations. Data were analyzed using content analysis. Findings indicate that, most GCSOs in Tanzania were poor in terms of resources to disseminate innovations to PCSos. Most GCSOs were also not determined at prioritizing and utilizing available resources for dissemination of innovations to PCSos. Further, some external factors e.g. inadequate government resources commitment, employment freezing and others have been adversely affecting GCSOs resources capability to disseminate innovations to PCSos. Moreover, there were no formal and comprehensive incentive systems to reward innovation dissemination activities in most of the GCSOs. It is recommended that GCSOs should mobilize more internal resources and ensure sufficient innovation resources prioritization and utilization to adequately facilitate innovations dissemination to PCSos. The GCSOs should also establish clear incentive systems to reward innovation dissemination activities.
Jurnal Manajemen Bisnis dan Kewirausahaan
Authors: Manajemen Admin Magister
Published: January 2020

Jurnal Manajemen Bisnis dan Kewirausahaan
The Legal Accountability Transportation To The Passengers And Goods Transport That Caused By Forgetfulness
Authors: Hsb Putra Halomoan
Published: January 2020

ملحصمسؤلية الحكم النقلى على الراكب والموادها وتبديل خاسربن من الإهتمال في الركاب. تبحث هذه الكتابة عن الركاب تشتمل على تعريفات الركاب ، فرد ومفرود الركاب , أنواعها وصفاتها واهدافها وعلاقتها على الراكب ومواده ، وتبحث أيضا عن عقابة التي تخسر بها. تخسر عن الركاب على الراكب في الركابة منها : مسؤولية الركوبة عند تجد فيها الفاسد أو تفقد بسب الاهتمال عند الركابة والتحديدات المسؤوليات في الركابة . هناك عدة مسؤولية في الركابة للراكب وهي ومسؤولية من جهة الأخطاء والإهتمالات ، ومسؤولية من جهة الظن والمطلق . ومن ثم هذه المقالة تتكلم عن الحقوق والواجبات من الراكب ومركوبها.الكمات الرئيسية : مسؤولية الحكم ، مركوبة الراكب ، والإهتمال .         AbstrakPertanggungjawaban Hukum Pengangkutan Terhadap Penumpang Dan Barang Angkutan  Serta Ganti Kerugian Disebabkan Kelalaian : Artikel ini membahas tentang ruang lingkup pengangkutan termasuk definisi pengangkutan, objek dan pihak pengangkutan, jenis-jenis pengangkutan sifat dan tujuan pengangkutan serta kaitannya dengan penumpang dan barang angkutan, serta membahas tentang sanksi kerugian. Serta pertanggungjawaban pengangkutan ketika terjadi kerusakan serta kehilangan barang penumpang yang disebabkan kelalaian pihak pengangkut, dan batasan batasan yang termasuk dalam tanggungjawab pengangkutan.  Dimana terdapat beberapa jenis-jenis pertanggungjawaban yang dilakukan oleh pihak pengangkut yakni pertanggungjawaban pengangkutan dilihat dari kesalahan dan kelalaian, pertanggungjawaban karena praduga dan pertanggungjawaban mutlak. Selanjutnya berbicara tentang hak dan kewajiban para pihak.
Sutry Jezusa – pierwsze syntezy chrystologiczne Dalekiego Wschodu
Authors: Klejnowski-Różycki Dariusz
Published: January 2020

Artykuł prezentuje badania dotyczące zabytkowych „dokumentów nestoriańskich” zwanych Sutrami Jezusa, które powstały podczas pierwszej misji Kościoła Wschodu do Chin w VII w. pod przewodnictwem Alopena. Teksty te są syntezą chrystologii oraz elementów teologii chrześcijańskiej istotną z punktu widzenia misji w Chinach. Opisują dogmaty chrześcijańskie za pomocą taoistycznej i buddyjskiej terminologii, filozofii, antropologii, kosmologii i symboliki. Są świadectwem rozwoju Kościoła w Chinach w ciągu trzech wieków za panowania dynastii Tang. Sutry Jezusa są odpowiedzią na pytanie: co i w jaki sposób opowiedział Kościół o Jezusie Chrystusie po raz pierwszy Dalekiemu Wschodowi?

Większość omawianych tekstów odkryta została w 1900 r. i jest przedmiotem badań teologów i sinologów głównie japońskich, chińskich i angielskojęzycznych. Jednocześnie badania te zupełnie są nieznane w polskiej przestrzeni teologicznej.

Artykuł przedstawia pełną listę tych dokumentów, proponując polską nazwę oraz krótkie ich omówienie jako przyczynek do dalszych badań nad nimi. Wśród Sutr Jezusa znajduje się kamienna Stela z Xi’an z wyrytym tekstem doktrynalno-historycznym istotnym także z punktu widzenia rozwoju doktryny chrześcijańskiej w Chinach.

Wnioski podkreślają wagę studiowania teologii nieeuropejskich kodowanych w innych systemach kultury i filozofii oraz pewne możliwości przekazu chrześcijańskiej doktryny także w symbolice innych religii (taoizm, buddyzm) z zachowaniem istoty rzeczy.
The unity of the Church in Saint Irenaeus’ ecclesiology
Authors: Ciascai Claudiu Marius
Published: January 2020

The unity of the Church from everywhere has always been of major concern for the early Christians. They understood this unity as an existing and tangible experience, and not as a remote perspective hidden in the uncertainty of the future. Besides, they believed that the unity of the Church can assure the cohesion between the Christian communities, and the communication inside the Christian community was, in its turn, the essential condition that provided the support for, the consolidation and the development of the ecclesiastic unity. The Fathers of the Church have understood the importance of keeping and supporting the unity and the stability inside the Church, in order to provide an efficient Christian mission everywhere in the world. The purpose of this study is to demonstrate the evolution and complexity of the ecumenical dimension of the ecclesiology of Irenaeus of Lyon, one of the most representatives of the Fathers of the Church, during the early centuries. He understood the power of the dialogue and the pastoral mission, and he preached not only for the early Christians, who, at that time, found themselves surrounded and confused by different inaccurate doctrines, but also for the pagans. He preached to those pagans the message of Jesus Christ’s Gospel of love.
Openness to interreligious dialogue – psychological antecedents and processes
Authors: Krok Dariusz , Król Przemysław
Published: January 2020

The aim of this article is to examine psychological antecedents and processes that play a crucial role in building and developing openness to interreligious dialogue. Two factors turn out to determine the ways in which interreligious dialogue is led: personality traits (agreeableness and openness to experience) and religious attitudes (intrinsic religiosity). They create an atmosphere of tolerance, which is especially important in dialogue as it promotes the religious freedom that is a necessary condition for interreligious dialogue. The effectiveness of interreligious dialogue depends on the presence of personal and group factors which all contribute to the final outcome, e.g. genuine autonomy of religious motivation, the ability to differentiate between essential and peripheral elements in religion, or authenticity of religious beliefs connected with commitment. They frequently interact with each other in influencing the final forms of interreligious dialogue.
Dialog Kościoła katolickiego z niewierzącymi
Authors: Kochel Jan
Published: January 2020

Artykuł podejmuje aktualny temat potrzeby dialogu z osobami niewierzącymi. Dialog to rozmowa co najmniej dwóch osób, może on być rozumiany jako metoda, proces i postawa społeczna. Dialog ekumeniczny obejmuje obszary, na których nie ma do końca zgody między rozmówcami, domaga się szacunku i umiejętności słuchania argumentów drugiej strony. Współcześnie rośnie zjawisko niewiary, zwłaszcza wśród młodych, stąd potrzeba poszukiwania form spotkań i dialogu ze współczesnym środowiskiem zsekularyzowanym. Kościół powszechny podejmuje różne próby dialogu z niewierzącymi: od propozycji inicjowanych przez oficjalne dokumenty Magisterium, poprzez inicjatywy lokalnych wspólnot i Kościołów, np. „katedra (warsztaty) dla niewierzących”, aż po uniwersalne forum wymiany tzw. „dziedziniec pogan (dialogu)”.
Choroba jako problem teologiczny – szkic do ujęcia ekumenicznego
Authors: Froniewski Jacek
Published: January 2020

Choroba w życiu każdego człowieka rodzi wiele pytań natury egzystencjalnej, stąd jest to także istotny problem teologiczny. Ze względu na uniwersalność doświadczenia choroby wydaje się konieczną próba ukazania tego zagadnienia w perspektywie ekumenicznej. Temat opracowano w trzech zasadniczych częściach. Część pierwsza, jako wprowadzająca w problematykę, zajmuje się zdefiniowaniem pojęcia choroby oraz poszukiwaniem płaszczyzny dialogu w tej kwestii między nowoczesną medycyną a współczesną teologią. Następnie autor przechodzi do prezentacji problemu w sferze ściśle ekumenicznej, gdzie nakreśla w dwóch częściach współczesne ujęcia zagadnienia choroby reprezentatywne kolejno dla teologii prawosławnej oraz protestanckiej. Stanowisko teologii prawosławnej przedstawione zostało w oparciu o prace J.-C. Larcheta i uzupełnione o poglądy J. Zizioulasa. Natomiast protestancką teologię choroby zaprezentowano w ujęciu K. Bartha. Każda z tych tradycji chrześcijańskich ma tu swoją wyraźną specyfikę, ale wspólnym elementem, choć z różną intensywnością, jest podejście personalistyczne, które potencjalnie wydaje się być tu szczególnie cenne dla dialogu teologii z nowoczesną medycyną.
Arcydzieła El Greca – namalowana kontrreformacja
Authors: Chałupniak Radosław
Published: January 2020

Termin „sztuka potrydencka” używany jest w odniesieniu do powstającej po Soborze Trydenckim (1545-1563) sztuki sakralnej. Sztuka religijna XVI i XVII wieku włączyła się w działania związane z kontrreformacją, broniąc dogmatów Kościoła rzymskokatolickiego i polemizując z protestantami. W artykule podjęto ważne pytania: Dlaczego dzieła El Greco można zaliczyć do tzw. „przedstawień kontrreformacyjnych”? Jakie tematy i w jaki sposób poruszane tematy przemawiały na rzecz wiary głoszonej przez Kościół rzymskokatolicki? Na ile sam El Greco miał świadomość, że przez swoje arcydzieła bronił, uzasadniał i potwierdzał nauczanie tego Kościoła?
Rational Enzyme Design Without Structural Knowledge: A Sequence-Based Approach for Effi-Cient Generation of Glycosylation Catalysts
Authors: Teze David , Jiao Zhao, , Wiemann Mathias , Gulshan Kazi Zubaida , Lupo Rossana , Rønne Mette Errebo , Carlström Göran , Duus Jens Øllgaard , Sanejouand Yves-Henri , O’Donohue Michael J. , Karlsson Eva Nordberg , Fauré Régis , Stålbrand Henrik , Svensson Birte
Published: January 2020

We present an enzyme engineering approach based solely on amino-acids sequence to convert glycoside hydrolases into transglycosylases. We demonstrate its effectiveness on enzymes form five different glycoside hydrolase families, synthesizing various oligosaccharides containing different α-/β-pyranosides or furanosides in one-step with high yields.
Discovery of a Difluoroglycine Synthesis Method through Quantum Chemical Calculations
Authors: Mita Tsuyoshi , Harabuchi Yu , Maeda Satoshi
Published: January 2020

The systematic exploration of synthetic pathways to afford a desired product through quantum chemical calculations remains a considerable challenge. In 2013, Maeda et al. introduced ‘quantum chemistry aided retrosynthetic analysis’ (QCaRA), which uses quantum chemical calculations to search systematically for decomposition paths of the target product and propose a synthesis method. However, until now, no new reactions suggested by QCaRA have been reported to lead to experimental discoveries. Using a difluoroglycine derivative as a target, this study investigated the ability of QCaRA to suggest various synthetic paths to the target without relying on previous data or the knowledge and experience of chemists. Furthermore, experimental verification of the seemingly most promising path led to the discovery of a synthesis method for the difluoroglycine derivative. The extent of the hands-on expertise of chemists required during the verification process was also evaluated. These insights are expected to advance the applicability of QCaRA to the discovery of viable experimental synthetic routes.
Late-Stage 18O Labeling of Primary Sulfonamides via a Degradation-Reconstruction Pathway
Authors: Reilly Sean , Bennett Frank , Fier Patrick , Ren Sumei , Strotman Neil A.
Published: January 2020

A late-stage 18O labeling approach of sulfonamides that employs the corresponding unlabeled molecule as the starting material was developed. Upon deamination of the sulfonamide, a sulfinate intermediate was isotopically enriched using eco-friendly reagents H218O and 15NH3(aq) to afford a M+5 isotopologue of the parent compound. This degradation-reconstruction approach afforded isolated yields of up to 96% for the stable isotope labeled (SIL) sulfonamides, and was compatible with multiple marketed therapeutics, including celecoxib, on a gram scale. The SIL products also exhibited no 18O/16O back exchange under extreme conditions, further validating the utility of this green strategy for drug labeling for both in vitro and in vivo use. This procedure was also adapted to include pharmaceutically relevant methyl sulfones by using 13CH3, affording M+5 isotopic enrichment, thereby illustrating the broad utility of this methodology.
Exploration of Ayurveda blueprint on clinical physiology of Meda (adipose tissue) and Majja Dhatu (bone marrow) in context to obesity
Authors: Vandana Verma  , Sonam Agrawal  , Sangeeta Gehlot
Published: January 2020

The state of health depends on the functional state of Dosha, Dhatu, Mala, Srotas, and Agni. The concept of functional and nutritional interdependence of Dhatu as well as a physiological and pathological aspect of all the seven Dhatu has been described by Ayurveda scholars. The metabolic effect of Meda and Majja Dhatu on other tissues like a muscle (Mamsa Dhatu), bone (Asthi Dhatu), and reproductive tissue (Shukra Dhatu) show their functional interdependence. The Ayurveda compendia, as well as recent research data, shows that obesity is the disorder of nutrition, which depends on lifestyle and diet. The obesity has been discussed in relation to Medovaha Srotodushti and Meda Dhatu Vriddhi. Although the physiology of Vasa, Meda, and Majja tissue has not been elaborated much, their clinical physiology has been described. This article aims to comprehend the pathophysiology of obesity as well as manifestations on the disturbed functional state of Meda and Majja Dhatu, as depicted by Ayurveda scholars in light of contemporary science. This article will be helpful in developing a vision regarding the clinical physiology of Meda and Majja, which will be further helpful in the exploration of pathophysiology and the management of obesity and associated disorders manifested by them. On exhaustive study, it was observed that the clinical physiology of Meda and Majja Dhatu shares quite a resemblance with the outcomes of contemporary researches on adipocytes, but still, some of these are still under the research.
An overview on topical drug delivery system – Updated review
Authors: Sharadha M  , Gowda D V  , Vishal Gupta N  , Akhila A R
Published: January 2020

The paper reviews an overview of a conventional and novel approach in the topical drug delivery system. Drug delivery via the skin is becoming progressively popular due to its convenience and affordability. The skin is the most important mechanical barrier to the penetration of many drug substances and acts as an ideal site to deliver the drug both locally and systemically. The topical route has been a favored route of drug administration over the last decades. Despite conventional topical drug delivery systems limits in poor retention and low bioavailability. This drawback overcomes by extensive research to develop a novel topical drug delivery systems targeting to improve the safety, efficacy and to minimize side effects. The conventional review focuses on dusting powders, poultices, plasters, lotion, liniments, solution, emulsion, suspension, colloidions, tinctures, creams, gels, ointments, pastes, suppositories, transdermal delivery systems, tapes, and gauzes and rubbing alcohol while the novel review focuses on novel gels, aerosol foams, microsponges, muco-adhesive bio-adhesives, novel vesicular carriers, nano-emulsion & nano-emulgel, protein and peptide delivery, polymers, emulsifier-free formulations and fullerenes etc. The key purpose of a topical delivery system is to enhance the skin permeability and to retain in the dermis. This review addresses a basis for further advancement and up-gradation of current techniques and technologies.
Facilitating the Bloom of Intestinal Flora: Observing the Influence of Tetrahydrocannabinol (THC) on Beneficial Bacteria Inhabiting the Intestinal Microbiota
Authors: Gindin Simona , Karia Esha , Petrushkevich Alisiya , Sadeghian Shadi
Published: January 2020

Healthy human bodies are inhabited by over 100 trillion bacterial cells [1]. The study of the symbiotic relationship between humans and these unicellular organisms has become of great importance in the medical field. In fact, the pathology of many diseases involves perturbation of the intestinal flora [1]. Tetrahydrocannabinol (THC), the psychotropic ingredient of cannabis, has caught the attention of healthcare researchers given its ability to increase appetite, and reduce nausea and inflammation
[2]. THC has also been associated with modulating the effects arising in the endocannabinoid system (ECS), however, its ability to affect bacteria growth has not been studied [3]. This proposed experiment seeks to explore the growth and vitality of beneficial gut microbiota (Lactobacillus acidophilus (LA), Akkermansia muciniphila (AM), Bifidobacterium bifidum (BB), and Streptococcus thermophilus (ST)) upon exposure to THC [4]. Through utilizing an experimental approach, beneficial bacterial cultures will be collected to study the growth of the microorganisms incubated with THC, relative to a positive and negative control. The results of the proposed study could inform future experiments investigating the treatment of a range of diseases with cannabis. The benefits of these treatments could also be extended to improving the daily health of the general population.
DETERMINATION OF THE IN VITRO EFFECT OF LEMONGRASS (Cymbopogon flexuosus) OIL AGAINST FISH PATHOGENIC BACTERIA ISOLATED FROM CULTURED OLIVE FLOUNDER (Paralichthys olivaceus)
Authors: Pathirana HNKS , Wimalasena SHMP , De Silva BCJ , Hossain S , Gang-Joon Heo
Published: January 2020

The antibacterial activity of essential oil from lemongrass (Cymbopogon flexuosus) (LGO) was tested against strains of Edwardsiella tarda (n=4), Photobacterium damselae (n=1), Lactococcus garvieae (n=1), Streptococcus iniae (n=4) and S. parauberis (n=4) isolated from cultured olive flounders in Korea. Disk diffusion assay, MIC (minimum inhibitory concentration) and MBC (minimum bactericidal concentration) tests showed the strains of Streptococcus spp. were the most sensitive. LGO was bactericidal (MBC/MIC=1-4) for all strains of L. garvieae, S. iniae and the FP5060 strain of E. tarda, and the FP5228, S527 and S1466 strains of S. parauberis suggesting sensitivity to LGO. Gram-negative bacteria were less sensitive than Gram-positive bacteria. Since antibacterial activity of LGO was effective against fish pathogenic bacteria tested in this study, the use of LGO could be helpful in treating such bacterial infections in fish.Key words: lemongrass oil; olive flounders; fish pathogenic bacteria; antimicrobial activity IN VITRO UČINEK OLJA LIMONSKE TRAVE (Cymbopogon flexuosus) PROTI RIBJI PATOGENI BAKTERIJI, IZOLIRANI IZ GOJENEGA MORSKEGA LISTA (Paralichthys olivaceus) Povzetek: Protibakterijsko delovanje eteričnega olja limonske trave (Cymbopogon flexuosus; LGO) je bilo preizkušeno glede njihovega delovanja proti sevom bakterij Edwardsiella tarda (n = 4), Photobacterium damselae (n = 1), Lactococcus garvieae (n = 1), Streptococcus iniae (n = 4) in S. parauberis (n = 4) pridobljenih iz gojenih morskih listov v Koreji. Difuzijska metoda z diskom ter testi MIC (najmanjša zaviralna koncentracija) in MBC (najmanjša baktericidna koncentracija) so pokazali, da so bili sevi Streptococcus spp. najbolj občutljivi. LGO je imel baktericidno delovanje (MBC / MIC = 1-4) na vse seve L. Garvieae in S. Iniae ter na seva FP5060 in FP5228 E. Tarda in seva S527 in S1466 S. parauberis. Gram-negativne bakterije so bile manj občutljive od gram-pozitivnih bakterij. Ker je bilo antibakterijsko delovanje LGO učinkovito proti ribjim patogenim bakterijam, preizkušenim v tej študiji, bi lahko uporaba LGO pomagala pri zdravljenju tovrstnih bakterijskih okužb pri ribah.Ključne besede: olje limonske trave; morski list; patogene bakterije rib; protimikrobno delovanje
A Preliminary Study: Comparative Toxicity of Extracts from Tinospora tuberculata Beumee and Lumnitzera racemosa Willd on Aedes aegypti Linnaeus Larvae (Diptera: Culicidae)
Authors: Wahizatul A. A. , Shasita R.
Published: January 2020

Research has been widely made on the  potential use of herbal plants as effective agents for mosquito vector control. However, only a few studies have been carried out to investigate the potential insecticidal activity of mangrove plants against these dengue vectors. This study was carried out to examine the comparative toxicity of two mangrove plants, Tinospora tuberculata and Lumnitzera racemosa against the Aedes aegypti larvae. The leaf and stem of T. tuberculata and L. racemosa, were extracted using 95% methanol and these extracts bioassayed against the 3rd instar larvae of  aegypti under laboratory conditions.  The LC50 values of the crude extract of T. tuberculata stem and leaf were 0.5778 mg/ml and 0.7213 mg/ml, respectively. For L. racemosa, the LC50 value for stem was 1.2833 mg/ml and 1.1957 mg/ml for leaf. However, no significant differences in toxicity were detected for the stem and leaf of both plants. Both plants, especially T. tuberculata might contain insecticidal components toxic to larvae of Ae aegypti.
PENGARUH MALTOSA SEBAGAI KRIOPROTEKTAN EKSTRASELULER DALAM MENINGKATKAN KUALITAS SEMEN BEKU GUNA MENDUKUNG KEBERHASILAN TEKNOLOGI INSEMINASI BUATAN
Authors: Herdis Herdis , Darmawan I wayan Angga
Published: January 2020

The research carried out to observe the effect of maltose addition on the quality of frozen semen of garut rams. Semen was collected once a week using artificial vagina from six mature garut rams. Semen was equilibrated at 5oC for four hours, frozen and stored in liquid nitrogen. The thawing was carried out at the temperature 30oC for 30 seconds. The result showed that percentages of viable sperm for addition of maltose 1,2 g / 100 ml extender (68,50 ± 0,84%) was significantly difference (P<0,05) than control (54,83 ± 1,94%) and addition of maltose 0,6 g / 100 ml extender (65,67 ± 1,03 %). The percentages of progressive motile sperm and percentages of plasma membrane for addition of maltose 1,2 g / 100 ml extender (53% and 64,67%) were significantly difference (P<0,05) than control (43% and 53,83%) but were not significantly different (P>0,05) from addition of maltose 0,6 g / 100 ml extender (50,83% and 64,67%)respectively. In conclusion, the addition of maltose 1,2 g / 100 ml extender is optimal dose to improve the quality of frozen semen of garut rams.
BIOKOMPOS CAIR DAN PUPUK KIMIA NPK SEBAGAI ALTERNATIF NUTRISI PADA BUDIDAYA TANAMAN CAISIM TEKNIK HIDROPONIK
Authors: Djamhari Sudaryanto
Published: January 2020

Technique hydroponic system with Nutrient Film Technique (NFT), is one way of vegetable crops that can be done in a narrow and without the use of soil media. Nutrition is done by pouring so that it can carry oxygen (O2) from the air. Generally fertilizer nutrient used in hydroponic technique is AB-mix, this study sought to examine alternative combinations of NPK fertilizer and liquid biokompos on some degree of concentration thatcan provide optimum production growth in crop varieties caisim Tosakan. This experiment used Completely Randomized Design (CRD) with 4 treatments. Data analysis was performed using different test each plant and resumed Duncan Multiple Test Distance otherwise known Duncan's Multiple Range Test (DMRT) at 5% level (F count> F table orP> 0.05) was conducted to determine the extent of the effect is real or not experiment treatmentResearch results indicate that administration of a mixture of NPK fertilizer and liquid fertilizer biokompos An1O1 the treatment can be used as a substitute for AB-mix in the provision of nutrition to the cultivation of varieties caisim Tosakan with hydroponictechniques. An1O1 treatment is the best dose when compared to the control treatment AB-mix, An2O2, and An3O3 the highest production yield component (gross production amounted to 97.67 g / plant and 85.75 g CP / tan).
How many ways can we teach data literacy?
Authors: Dai Yun
Published: January 2020

Academic Libraries are ideally positioned to teach data literacy. What is ‘data literacy’ in the first place? Is it the new information literacy? Will the ways we teach information literacy limit imaginative ways to teach data literacy?

With those questions in mind, the Library of New York University Shanghai has explored multiple ways to teach data literacy to undergraduate students through university events, ‘for-class’ instruction and workshops, and online casebooks. (1) We initiated the yearlong series of events titled ‘Lying with Data’, inviting faculty across disciplines to each address one core data literacy question that students of data science may elude. (2) We offered workshops and in-class instruction that are up-to-date with the latest technology and that fit with the curriculum. (3) We created online casebooks on various topics in the data lifecycle, tackling user needs at different levels. Essential to our teaching activities are two core values: ‘let the quality speak for itself’, and ‘outreach by teaching’.
Pengaruh Penerapan Model Pembelajaran Inkuiri Terhadap Hasil Belajar Tentang Sistem Gerak
Authors: Anggraini Baiq Nely Widya , Syachruddin AR Syachruddin AR , Ramdani Agus
Published: January 2020

Penelitian ini bertujuan untuk mengetahui pengaruh penerapan model pembelajaran inkuiri terhadap hasil belajar tentang sistem gerak pada peserta didik kelas VIII di SMP Negeri 1 Mataram tahun 2018. Jenis penelitian ini adalah quasi experiment dengan desain nonequivalent control group design. Populasi dalam penelitian ini yaitu seluruh peserta didik kelas VIII di SMP Negeri 1 Mataram tahun 2018 yang terdiri dari 11 kelas. Sampel ditentukan dengan menggunakan teknik simple random sampling sehingga terpilih kelas VIII A sebagai kelas kontrol dan VIII B sebagai kelas eksperimen. Instrumen yang digunakan dalam penelitian yaitu tes objektif untuk mengukur hasil belajar peserta didik. Analisis data menggunakan uji t. Data yang diperoleh menunjukkan bahwa hasil belajar peserta didik kelas eksperimen meningkat sebesar 36,6 (dari 33,4 ke 70) sedangkan hasil belajar kelas kontrol meningkat sebesar 30,7 (dari 29,25 ke 59,95). Analisis data pada skor capaian menunjukkan thitung lebih besar dibanding ttabel (2,05 > 1,99). Hal ini disebabkan karena model inkuiri memberikan peserta didik kesempatan untuk menemukan masalah, mencari jawaban dan menyimpulkannya, peserta didik belajar dengan memanfaatkan lingkungannya, dan bekerja sesuai prosedur ilmiah. Hasil analisis terhadap nilai capaian menunjukkan adanya perbedaan hasil belajar pada kelas yang menggunakan inkuiri dengan yang tidak. Berdasarkan hasil tersebut dapat disimpulkan bahwa terdapat pengaruh signifikan dari penerapan model pembelajaran inkuiri terhadap hasil belajar tentang sistem gerak pada peserta didik kelas VIII di SMP Negeri 1 Mataram tahun 2018.
Pengaruh Model Problem Based Learning (PBL) Terhadap Kemampuan Komunikasi Siswa Materi Pokok Larutan Elektrolit Dan Non-Elektrolit
Authors: Iftitahurrahimah Iftitahurrahimah , Andayani Yayuk , Al Idrus Syarifa Wahidah
Published: January 2020

Penelitian ini bertujuan untuk mengetahui pengaruh model Problem Based Learning (PBL) terhadap kemampuan komunikasi siswa pada materi pokok larutan elektrolit dan non-elektrolit. Penelitian quasy eksperimen menggunakan rancangan post-test only control grup design dengan populasi seluruh siswa kelas X MIA SMAN 8 MATARAM. Kelas X MIA 3 sebagai kelas eksperimen yang diajarkan dengan model Problem Based Learning (PBL) dan kelas X MIA 4 sebagai kelas kontrol yang diajarkan dengan model konvensional ditentukan dengan teknik purposive sampling. Data kemampuan komunikasi siswa dikumpulkan menggunakan tes tulis untuk kemampuan komunikasi tulisan, sedangkan lembar observasi untuk data kemampuan komunikasi lisan. Hasilnya menunjukkan bahwa rata-rata kemampuan komunikasi tulisan siswa di kelas eksperimen yaitu 75,15 dengan kriteria tinggi, sedangkan di kelas kontrol 57,10 dengan kriteria sedang, kemampuan komunikasi lisan siswa di kelas eksperimen yaitu 10,54 dengan kriteria sangat rendah dan di kelas kontrol yaitu 5,18 dengan kriteria sangat rendah. Berdasarkan uji hipotesis menggunakan uji-t pada taraf signifikan 5% menunjukkan bahwa model Problem Based Learning memberikan pengaruh terhadap kemampuan komunikasi tulisan siswa materi pokok larutan elektrolit dan non-elektrolit. Uji hipotesis menggunakan uji-t juga menunjukkan bahwa model Problem Based Learning memberikan pengaruh terhadap kemampuan komunikasi lisan siswa materi pokok larutan elektrolit dan non-elektrolit.