bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure Legends from MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin
Authors: O'Brien Rosemary , Tran Sieu L. , Maritz Michelle F. , Liu Bing , Kong Cheng Fei , Purgato Stefania , Yang Chen , Murray Jayne , Russell Amanda J. , Flemming Claudia L. , von Jonquieres Georg , Pickett Hilda A. , London Wendy B. , Haber Michelle , Gunaratne Preethi H. , Norris Murray D. , Perini Giovanni , Fletcher Jamie I. , MacKenzie Karen L.
Published: April 2023

Text file of Figure Legends to Supplementary data
Supplementary Figures S1-S9 from Quantitative Phosphotyrosine Profiling of Patient-Derived Xenografts Identifies Therapeutic Targets in Pediatric Leukemia
Authors: Dolai Sibasish , Sia Keith C.S. , Robbins Alissa K. , Zhong Ling , Heatley Sue L. , Vincent Tiffaney L. , Hochgräfe Falko , Sutton Rosemary , Kurmasheva Raushan T. , Revesz Tamas , White Deborah L. , Houghton Peter J. , Smith Malcolm A. , Teachey David T. , Daly Roger J. , Raftery Mark J. , Lock Richard B.
Published: April 2023

Phosphotyrosine sites identified by immunoaffinity profiling in ALL PDXs (S1); Comparison of phosphotyrosine enrichment from fresh and frozen PDX (S2); Optimization of quantitative phosphotyrosine profiling of pediatric ALL PDXs (S3); Number of identified Class I phosphosites in each of the PDXs (S4); Unsupervised hierarchical clustering of Class I phosphosites in ALL PDXs segregated based on molecularly-defined subgroups (S5); Comparison of ETP-ALL, Ph-like-ALL, BCP-ALL and T-ALL PDXs by gene expression profiling (S6); Comparison of phosphorylation levels of pTyr sites with gene expression profiling (S7); In vitro sensitivity of ALL PDXs to Sunitinib (S8); Venn diagram showing the number of Light PDX phosphopeptides and Heavy SILAC labelled phosphopeptides identified in each of the 16 PDXs (S9).
Supplementary Figure Legends from Quantitative Phosphotyrosine Profiling of Patient-Derived Xenografts Identifies Therapeutic Targets in Pediatric Leukemia
Authors: Dolai Sibasish , Sia Keith C.S. , Robbins Alissa K. , Zhong Ling , Heatley Sue L. , Vincent Tiffaney L. , Hochgräfe Falko , Sutton Rosemary , Kurmasheva Raushan T. , Revesz Tamas , White Deborah L. , Houghton Peter J. , Smith Malcolm A. , Teachey David T. , Daly Roger J. , Raftery Mark J. , Lock Richard B.
Published: April 2023

Legend for Supplementary Figures S1-S9.
Supplementary figure 5 from Abscopal Effects of Radiotherapy Are Enhanced by Combined Immunostimulatory mAbs and Are Dependent on CD8 T Cells and Crosspriming
Authors: Rodriguez-Ruiz María E. , Rodriguez Inmaculada , Garasa Saray , Barbes Benigno , Solorzano Jose Luis , Perez-Gracia Jose Luis , Labiano Sara , Sanmamed Miguel F. , Azpilikueta Arantza , Bolaños Elixabet , Sanchez-Paulete Alfonso R. , Aznar M. Angela , Rouzaut Ana , Schalper Kurt A. , Jure-Kunkel Maria , Melero Ignacio
Published: April 2023

single dose radiotherapy and hypofractionated doses increase the level of CD137 and PD-1 expression on the surface of tumor-infiltrating T cells.
Supplementary Figure Legends from Histone Deacetylase Inhibition in Prostate Cancer Triggers miR-320–Mediated Suppression of the Androgen Receptor
Authors: Sato Shinya , Katsushima Keisuke , Shinjo Keiko , Hatanaka Akira , Ohka Fumiharu , Suzuki Shugo , Naiki-Ito Aya , Soga Norihito , Takahashi Satoru , Kondo Yutaka
Published: April 2023

Legends for supplemental figures
Supplementary figure 1 from Abscopal Effects of Radiotherapy Are Enhanced by Combined Immunostimulatory mAbs and Are Dependent on CD8 T Cells and Crosspriming
Authors: Rodriguez-Ruiz María E. , Rodriguez Inmaculada , Garasa Saray , Barbes Benigno , Solorzano Jose Luis , Perez-Gracia Jose Luis , Labiano Sara , Sanmamed Miguel F. , Azpilikueta Arantza , Bolaños Elixabet , Sanchez-Paulete Alfonso R. , Aznar M. Angela , Rouzaut Ana , Schalper Kurt A. , Jure-Kunkel Maria , Melero Ignacio
Published: April 2023

Mouse external beam irradiation setting and combinations of radiotherapy and anti-CD137 and/or anti-PD1 immunostimulatory monoclonal antibodies are safe and effective to treat MC38-derived bilateral tumors of which only one of the tumor sites is irradiated.
Supplementary Figure Legends from Urokinase Receptor Promotes Skin Tumor Formation by Preventing Epithelial Cell Activation of Notch1
Authors: Mazzieri Roberta , Pietrogrande Giovanni , Gerasi Laura , Gandelli Alessandro , Colombo Piergiuseppe , Moi Davide , Brombin Chiara , Ambrosi Alessandro , Danese Silvio , Mignatti Paolo , Blasi Francesco , D'Alessio Silvia
Published: April 2023

This file include Supplementary Figure Legends
Supplementary Figure Legends from Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability
Authors: Li Xiangchun , Wu William K.K. , Xing Rui , Wong Sunny H. , Liu Yuexin , Fang Xiaodong , Zhang Yanlin , Wang Mengyao , Wang Jiaqian , Li Lin , Zhou Yong , Tang Senwei , Peng Shaoliang , Qiu Kunlong , Chen Longyun , Chen Kexin , Yang Huanming , Zhang Wei , Chan Matthew T.V. , Lu Youyong , Sung Joseph J.Y. , Yu Jun
Published: April 2023

Supplementary Figure Legends
Supplementary Figure 3 from Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability
Authors: Li Xiangchun , Wu William K.K. , Xing Rui , Wong Sunny H. , Liu Yuexin , Fang Xiaodong , Zhang Yanlin , Wang Mengyao , Wang Jiaqian , Li Lin , Zhou Yong , Tang Senwei , Peng Shaoliang , Qiu Kunlong , Chen Longyun , Chen Kexin , Yang Huanming , Zhang Wei , Chan Matthew T.V. , Lu Youyong , Sung Joseph J.Y. , Yu Jun
Published: April 2023

Fig. S3: Prognostic significance of CDH1 mutation.
Supplementary Material and Method Details from Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma
Authors: Vatolin Sergei , Phillips James G. , Jha Babal K. , Govindgari Shravya , Hu Jennifer , Grabowski Dale , Parker Yvonne , Lindner Daniel J. , Zhong Fei , Distelhorst Clark W. , Smith Mitchell R. , Cotta Claudiu , Xu Yan , Chilakala Sujatha , Kuang Rebecca R. , Tall Samantha , Reu Frederic J.
Published: April 2023

Reagent and chemical library screening details, liver homogenate preparation, CCF642 animal treatment formulation, chemical synthesis schemes, details of proteomic analysis, PDI activity assay and PDI mutant primer sequences
Supplementary Figure Legends from Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma
Authors: Vatolin Sergei , Phillips James G. , Jha Babal K. , Govindgari Shravya , Hu Jennifer , Grabowski Dale , Parker Yvonne , Lindner Daniel J. , Zhong Fei , Distelhorst Clark W. , Smith Mitchell R. , Cotta Claudiu , Xu Yan , Chilakala Sujatha , Kuang Rebecca R. , Tall Samantha , Reu Frederic J.
Published: April 2023

Legends to Supplementary Figures S1-4
Supplementary Figure Legend, Supplementary Materials and Methods, Supplmentary Figures 1-9 from Small RNAs Recruit Chromatin-Modifying Enzymes MMSET and Tip60 to Reconfigure Damaged DNA upon Double-Strand Break and Facilitate Repair
Authors: Wang Qinhong , Goldstein Michael
Published: April 2023

Supplementary Figure Legends, Figure S1 Dicer- and Drosha-dependent diRNAs are essential for HR repair, Figure S2 Dicer or Drosha is required for the recruitment of MMSET and Tip60 to the DSB, Figure S3 Chemically synthesized oligo-RNAs restored the accumulation of MMSET, Tip60, H4K20me2, 3 and H4K16 Ac at the DSB, Figure S4 Chemically synthesized oligo-RNAs rescued the accumulation of AGO2 at the DSB in Dicer- or Drosha-depleted U2OS cells, Figure S5 Phosphorylation of MMSET at serine 102 site and Tip60 at Tyrosine 44 site enhance the interaction of AGO2 with MMSET and Tip60 after IR (5Gy) exposure, Figure S6 diRNAs bind to AGO2/MMSET/Tip60 complex. A-C, DR-GFP/U2OS cells transfected with indicated siRNA for two days were further transfected with infected with pCBA-β vector expressing I-SecI for another one day, Figure S7 Chemically synthesized oligo-RNAs rescued the accumulation of Rad51 and BRCA1 at the DSB, Figure S8 MMST or Tip60 is essential for chromatin relaxation and the recruitment of Rad51 and BRCA1 to the DSB, Figure S9 Dicer or Drosha has no effect on DNA end resection, Supplementary Materials and Methods,
Supplemental materials and methods from GON4L Drives Cancer Growth through a YY1–Androgen Receptor–CD24 Axis
Authors: Agarwal Neeraj , Dancik Garrett M. , Goodspeed Andrew , Costello James C. , Owens Charles , Duex Jason E. , Theodorescu Dan
Published: April 2023

Supplementary materials and methods
Supplemental Figure 6 Drosophila brat-RNAi brains show increased Musashi expression. from Drosophila Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport
Authors: Mukherjee Subhas , Tucker-Burden Carol , Zhang Changming , Moberg Kenneth , Read Renee , Hadjipanayis Costas , Brat Daniel J.
Published: April 2023

Immunofluorescence for Drosophila Musashi in the Drosophila brat-RNAi brain shows that there is a moderate increase in Musashi expression when Brat protein is suppressed in neuroblasts (A-E).
Supplementary Table S1 from Antitumor Properties of an IgG2-Enhanced Next-Generation MET Monoclonal Antibody That Degrades Wild-Type and Mutant MET Receptors
Authors: Yang Yan , Mandiyan Sreekala , Robinson Brett S. , McMahon Gerald
Published: April 2023

Cross-species reactivity of anti-MET antibodies.
Supplementary Methods and References from Antitumor Properties of an IgG2-Enhanced Next-Generation MET Monoclonal Antibody That Degrades Wild-Type and Mutant MET Receptors
Authors: Yang Yan , Mandiyan Sreekala , Robinson Brett S. , McMahon Gerald
Published: April 2023

Description of additional methods and procedures used in the study. Also includes Supplementary References.
Figure S5 from Nkx2.8 Inhibits Epithelial–Mesenchymal Transition in Bladder Urothelial Carcinoma via Transcriptional Repression of Twist1
Authors: Yu Chunping , Liu Zhuowei , Chen Qiuhong , Li Yonghong , Jiang Lijuan , Zhang Zhiling , Zhou Fangjian
Published: April 2023

Ablation of Twist1 restores the inhibitory effect of Nkx2.8 on the motility of Nkx2.8-silenced UC cells
Figure S1 from Nkx2.8 Inhibits Epithelial–Mesenchymal Transition in Bladder Urothelial Carcinoma via Transcriptional Repression of Twist1
Authors: Yu Chunping , Liu Zhuowei , Chen Qiuhong , Li Yonghong , Jiang Lijuan , Zhang Zhiling , Zhou Fangjian
Published: April 2023

Silencing endogenous Nkx2.8 induces EMT of UC cells
Supplemental Figure Legends from JPO2/CDCA7L and LEDGF/p75 Are Novel Mediators of PI3K/AKT Signaling and Aggressive Phenotypes in Medulloblastoma
Authors: Chan Tiffany Sin Yu , Hawkins Cynthia , Krieger Jonathan R. , McGlade C. Jane , Huang Annie
Published: April 2023

Supplemental Figure Legends 1-8
Supplemental Figure 5 from JPO2/CDCA7L and LEDGF/p75 Are Novel Mediators of PI3K/AKT Signaling and Aggressive Phenotypes in Medulloblastoma
Authors: Chan Tiffany Sin Yu , Hawkins Cynthia , Krieger Jonathan R. , McGlade C. Jane , Huang Annie
Published: April 2023

LEDGF increases JPO2 protein levels
Supplemental tables 1-3 from HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis
Authors: Lang Michaela , Berry David , Passecker Katharina , Mesteri Ildiko , Bhuju Sabin , Ebner Florian , Sedlyarov Vitaly , Evstatiev Rayko , Dammann Kyle , Loy Alexander , Kuzyk Orest , Kovarik Pavel , Khare Vineeta , Beibel Martin , Roma Guglielmo , Meisner-Kober Nicole , Gasche Christoph
Published: April 2023

Antibody list, organoid culture medium reagents and primer sequences
Supplemental methods and references from HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis
Authors: Lang Michaela , Berry David , Passecker Katharina , Mesteri Ildiko , Bhuju Sabin , Ebner Florian , Sedlyarov Vitaly , Evstatiev Rayko , Dammann Kyle , Loy Alexander , Kuzyk Orest , Kovarik Pavel , Khare Vineeta , Beibel Martin , Roma Guglielmo , Meisner-Kober Nicole , Gasche Christoph
Published: April 2023

Additional information on mouse experiments, colonoscopy, histology, immunohistochemical analysis and amplicon sequencing for microbiota analysis
Supplemental table 2 from An Imbalance in TAZ and YAP Expression in Hepatocellular Carcinoma Confers Cancer Stem Cell–like Behaviors Contributing to Disease Progression
Authors: Hayashi Hiromitsu , Higashi Takaaki , Yokoyama Naomi , Kaida Takayoshi , Sakamoto Keita , Fukushima Yukiko , Ishimoto Takatsugu , Kuroki Hideyuki , Nitta Hidetoshi , Hashimoto Daisuke , Chikamoto Akira , Oki Eiji , Beppu Toru , Baba Hideo
Published: April 2023

Association between TAZ or YAP mRNA expression and patient's characteristics in hepatocellular carcinoma
Supplemental Figure 7: Chao1 and Shannon richness estimates and indicator OTUs for AOM/DSS mice. from HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis
Authors: Lang Michaela , Berry David , Passecker Katharina , Mesteri Ildiko , Bhuju Sabin , Ebner Florian , Sedlyarov Vitaly , Evstatiev Rayko , Dammann Kyle , Loy Alexander , Kuzyk Orest , Kovarik Pavel , Khare Vineeta , Beibel Martin , Roma Guglielmo , Meisner-Kober Nicole , Gasche Christoph
Published: April 2023

Alpha diversity in feces of AOM/DSS and APCMin upon MS-444 treatment and indicator OTUs in AOM/DSS mouse feces.
Supplemental figure 4 from An Imbalance in TAZ and YAP Expression in Hepatocellular Carcinoma Confers Cancer Stem Cell–like Behaviors Contributing to Disease Progression
Authors: Hayashi Hiromitsu , Higashi Takaaki , Yokoyama Naomi , Kaida Takayoshi , Sakamoto Keita , Fukushima Yukiko , Ishimoto Takatsugu , Kuroki Hideyuki , Nitta Hidetoshi , Hashimoto Daisuke , Chikamoto Akira , Oki Eiji , Beppu Toru , Baba Hideo
Published: April 2023

YAP knockdown in other gastrointestinal cancer cells (SW620 and TE-1 cells) with high YAP expression.
Suppl. Figure 7 from HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors
Authors: Budina-Kolomets Anna , Webster Marie R. , Leu Julia I-Ju , Jennis Matthew , Krepler Clemens , Guerrini Anastasia , Kossenkov Andrew V. , Xu Wei , Karakousis Giorgos , Schuchter Lynn , Amaravadi Ravi K. , Wu Hong , Yin Xiangfan , Liu Qin , Lu Yiling , Mills Gordon B. , Xu Xiaowei , George Donna L. , Weeraratna Ashani T. , Murphy Maureen E.
Published: April 2023

Impact of PET-16 on the level of HSP70 client proteins in vivo A. Immunofluorescence analysis for phospho-FAK (pTyr-397) in the tumors from mice described in (6G). Scale bar = 15 μm B
Supplemental Figure and Table Legends from A Radiotracer Strategy to Quantify PARP-1 Expression In Vivo Provides a Biomarker That Can Enable Patient Selection for PARP Inhibitor Therapy
Authors: Makvandi Mehran , Xu Kuiying , Lieberman Brian P. , Anderson Redmond-Craig , Effron Samuel Sander , Winters Harrison D. , Zeng Chenbo , McDonald Elizabeth S. , Pryma Daniel A. , Greenberg Roger A. , Mach Robert H.
Published: April 2023

Legends for supplemental figures and tables
Supplementary Information from A KDM5 Inhibitor Increases Global H3K4 Trimethylation Occupancy and Enhances the Biological Efficacy of 5-Aza-2′-Deoxycytidine
Authors: Leadem Benjamin R. , Kagiampakis Ioannis , Wilson Catherine , Cheung Tommy K. , Arnott David , Trojer Patrick , Classon Marie , Easwaran Hariharan , Baylin Stephen B.
Published: April 2023

Legends for Supplementary Figures and Tables
Supplementary table 1 and 2 from Tumor Suppressor HIPK2 Regulates Malignant Growth via Phosphorylation of Notch1
Authors: Ann Eun-Jung , Kim Mi-Yeon , Yoon Ji-Hye , Ahn Ji-Seon , Jo Eun-Hye , Lee Hye-Jin , Lee Hyun-Woo , Kang Hyeok-Gu , Choi Dong Wook , Chun Kyung-Hee , Lee Ji Shin , Choi Cheol Yong , Ferrando Adolfo A. , Lee Keesook , Park Hee-Sae
Published: April 2023

Supplementary Table S1: Immunohistochemical staining of Notch1-IC and HIPK2 in serial tissue arrays of 61 breast cancer samples. Supplementary Table S2: Semi-Quantitative analysis of Notch1-IC, phosphorylated Notch1-IC T2512, HIPK2, and Fbw7 expression in breast cancer tissues.
Supplementary Materials and Methods from Tumor Suppressor HIPK2 Regulates Malignant Growth via Phosphorylation of Notch1
Authors: Ann Eun-Jung , Kim Mi-Yeon , Yoon Ji-Hye , Ahn Ji-Seon , Jo Eun-Hye , Lee Hye-Jin , Lee Hyun-Woo , Kang Hyeok-Gu , Choi Dong Wook , Chun Kyung-Hee , Lee Ji Shin , Choi Cheol Yong , Ferrando Adolfo A. , Lee Keesook , Park Hee-Sae
Published: April 2023

Description of additional methods and procedures used in the study.
Figure S1 from A KDM5 Inhibitor Increases Global H3K4 Trimethylation Occupancy and Enhances the Biological Efficacy of 5-Aza-2′-Deoxycytidine
Authors: Leadem Benjamin R. , Kagiampakis Ioannis , Wilson Catherine , Cheung Tommy K. , Arnott David , Trojer Patrick , Classon Marie , Easwaran Hariharan , Baylin Stephen B.
Published: April 2023

KDM5i increases H3K4 trimethylation alone and in combination with DAC.
Supplementary Table and Figure 1 from MCAM and LAMA4 Are Highly Enriched in Tumor Blood Vessels of Renal Cell Carcinoma and Predict Patient Outcome
Authors: Wragg Joseph W. , Finnity Jonathan P. , Anderson Jane A. , Ferguson Henry J.M. , Porfiri Emilio , Bhatt Rupesh I. , Murray Paul G. , Heath Victoria L. , Bicknell Roy
Published: April 2023

Supplementary Table 1: Primer sequences for RTqPCR using the Roche Exiqon probe library system. Supplementary Figure 1. Representative images demonstrative of scoring for staining intensity. Images are of MCAM staining in RCC at a weak (i-ii) or strong (iii-iv) level with associated H&E images (v,vi,vii,viii) . Scale bar = 50 μm.
Supplementary Figures 1-5 from Ras Signaling Is a Key Determinant for Metastatic Dissemination and Poor Survival of Luminal Breast Cancer Patients
Authors: Wright Katherine L. , Adams Jessica R. , Liu Jeff C. , Loch Amanda J. , Wong Ruth G. , Jo Christine E.B. , Beck Lauren A. , Santhanam Divya R. , Weiss Laura , Mei Xue , Lane Timothy F. , Koralov Sergei B. , Done Susan J. , Woodgett James R. , Zacksenhaus Eldad , Hu Pingzhao , Egan Sean E.
Published: April 2023

Supplementary Figures 1-5. Supplementary Fig. 1. Kaplan-Meier overall survival curves and cause of death data for control and experimental female mice. Supplementary Fig. 2. Mammary pathology analysis and estrogen receptor α staining for experimental mice. Supplementary Fig. 3. Activation of Stat3 and Mapk signaling in mouse mammary tumors. Supplementary Fig. 4. Ras pathway activation is associated with relapse and survival of breast cancer patients independent of PI3K and Stat3 pathway activation. Supplementary Fig. 5. PI3K pathway activation is associated with relapse of patients with Basal-like breast cancer.
Supplementary Figure Legends from Ras Signaling Is a Key Determinant for Metastatic Dissemination and Poor Survival of Luminal Breast Cancer Patients
Authors: Wright Katherine L. , Adams Jessica R. , Liu Jeff C. , Loch Amanda J. , Wong Ruth G. , Jo Christine E.B. , Beck Lauren A. , Santhanam Divya R. , Weiss Laura , Mei Xue , Lane Timothy F. , Koralov Sergei B. , Done Susan J. , Woodgett James R. , Zacksenhaus Eldad , Hu Pingzhao , Egan Sean E.
Published: April 2023

Supplementary Figure Legends 1-5
Figure S2 from Mathematical Modeling Reveals That Changes to Local Cell Density Dynamically Modulate Baseline Variations in Cell Growth and Drug Response
Authors: Greene James M. , Levy Doron , Herrada Sylvia P. , Gottesman Michael M. , Lavi Orit
Published: April 2023

Detailed information of the mathematical model simulation results. Panel A) Sample initial and final configurations of the ABM used for comparison with 24 hour image control data. Panel B) Spatial deviation parameter search. Panel C) Rate of progression through the cell-cycle as a function of density and dosage. Panel D) 10 Monte Carlo long-time simulations of the ABM.
Supplementary Table 1 from Inactivation of Cancer-Associated-Fibroblasts Disrupts Oncogenic Signaling in Pancreatic Cancer Cells and Promotes Its Regression
Authors: Dauer Patricia , Zhao Xianda , Gupta Vineet K. , Sharma Nikita , Kesh Kousik , Gnamlin Prisca , Dudeja Vikas , Vickers Selwyn M. , Banerjee Sulagna , Saluja Ashok
Published: April 2023

Primers
Figure S5 from Inactivation of Cancer-Associated-Fibroblasts Disrupts Oncogenic Signaling in Pancreatic Cancer Cells and Promotes Its Regression
Authors: Dauer Patricia , Zhao Xianda , Gupta Vineet K. , Sharma Nikita , Kesh Kousik , Gnamlin Prisca , Dudeja Vikas , Vickers Selwyn M. , Banerjee Sulagna , Saluja Ashok
Published: April 2023

Treatment with ATRA promotes proliferation at low dose
Figure S4 from Inactivation of Cancer-Associated-Fibroblasts Disrupts Oncogenic Signaling in Pancreatic Cancer Cells and Promotes Its Regression
Authors: Dauer Patricia , Zhao Xianda , Gupta Vineet K. , Sharma Nikita , Kesh Kousik , Gnamlin Prisca , Dudeja Vikas , Vickers Selwyn M. , Banerjee Sulagna , Saluja Ashok
Published: April 2023

Differentially regulated genes in CAFs
Figure S3 from Inactivation of Cancer-Associated-Fibroblasts Disrupts Oncogenic Signaling in Pancreatic Cancer Cells and Promotes Its Regression
Authors: Dauer Patricia , Zhao Xianda , Gupta Vineet K. , Sharma Nikita , Kesh Kousik , Gnamlin Prisca , Dudeja Vikas , Vickers Selwyn M. , Banerjee Sulagna , Saluja Ashok
Published: April 2023

IHC of tumor from KPC mice
Supplementary Figure 1 from Cholesterol Metabolism and Prostate Cancer Lethality
Authors: Stopsack Konrad H. , Gerke Travis A. , Sinnott Jennifer A. , Penney Kathryn L. , Tyekucheva Svitlana , Sesso Howard D. , Andersson Swen-Olof , Andrén Ove , Cerhan James R. , Giovannucci Edward L. , Mucci Lorelei A. , Rider Jennifer R.
Published: April 2023

Association of Gleason grade with squalene monooxygenase (SQLE) expression in the Health Professionals Follow-up Study (HPFS) and Physicians' Health Study (PHS) combined (Ptrend < 0.001).
Supplementary Table and Figure Legends from Src Inhibition Blocks c-Myc Translation and Glucose Metabolism to Prevent the Development of Breast Cancer
Authors: Jain Shalini , Wang Xiao , Chang Chia-Chi , Ibarra-Drendall Catherine , Wang Hai , Zhang Qingling , Brady Samuel W. , Li Ping , Zhao Hong , Dobbs Jessica , Kyrish Matt , Tkaczyk Tomasz S. , Ambrose Adrian , Sistrunk Christopher , Arun Banu K. , Richards-Kortum Rebecca , Jia Wei , Seewaldt Victoria L. , Yu Dihua
Published: April 2023

Legend for Supplementary Table S1 and Supplementary Figures S1-S5.
Supplementary Table 6 from An Immune-Inflammation Gene Expression Signature in Prostate Tumors of Smokers
Authors: Prueitt Robyn L. , Wallace Tiffany A. , Glynn Sharon A. , Yi Ming , Tang Wei , Luo Jun , Dorsey Tiffany H. , Stagliano Katherine E. , Gillespie John W. , Hudson Robert S. , Terunuma Atsushi , Shoe Jennifer L. , Haines Diana C. , Yfantis Harris G. , Han Misop , Martin Damali N. , Jordan Symone V. , Borin James F. , Naslund Michael J. , Alexander Richard B. , Stephens Robert M. , Loffredo Christopher A. , Lee Dong H. , Putluri Nagireddy , Sreekumar Arun , Hurwitz Arthur A. , Ambs Stefan
Published: April 2023

Supplementary Table S6: Increased expression of genes regulating synaptic signal transduction in the cancerous prostate of nicotineâ€�treated TRAMP mice.
Supplementary Figure S4 from Src Inhibition Blocks c-Myc Translation and Glucose Metabolism to Prevent the Development of Breast Cancer
Authors: Jain Shalini , Wang Xiao , Chang Chia-Chi , Ibarra-Drendall Catherine , Wang Hai , Zhang Qingling , Brady Samuel W. , Li Ping , Zhao Hong , Dobbs Jessica , Kyrish Matt , Tkaczyk Tomasz S. , Ambrose Adrian , Sistrunk Christopher , Arun Banu K. , Richards-Kortum Rebecca , Jia Wei , Seewaldt Victoria L. , Yu Dihua
Published: April 2023

Effect of Src on Myc transcription, protein stability and synthesis.
Supplementary Figure S3 from Src Inhibition Blocks c-Myc Translation and Glucose Metabolism to Prevent the Development of Breast Cancer
Authors: Jain Shalini , Wang Xiao , Chang Chia-Chi , Ibarra-Drendall Catherine , Wang Hai , Zhang Qingling , Brady Samuel W. , Li Ping , Zhao Hong , Dobbs Jessica , Kyrish Matt , Tkaczyk Tomasz S. , Ambrose Adrian , Sistrunk Christopher , Arun Banu K. , Richards-Kortum Rebecca , Jia Wei , Seewaldt Victoria L. , Yu Dihua
Published: April 2023

Src regulates GLUT1 expression.
Supplementary Figure S1 from Src Inhibition Blocks c-Myc Translation and Glucose Metabolism to Prevent the Development of Breast Cancer
Authors: Jain Shalini , Wang Xiao , Chang Chia-Chi , Ibarra-Drendall Catherine , Wang Hai , Zhang Qingling , Brady Samuel W. , Li Ping , Zhao Hong , Dobbs Jessica , Kyrish Matt , Tkaczyk Tomasz S. , Ambrose Adrian , Sistrunk Christopher , Arun Banu K. , Richards-Kortum Rebecca , Jia Wei , Seewaldt Victoria L. , Yu Dihua
Published: April 2023

Targeting Src prevents the development of disorganized acinar growth.
Supplementary Figure S5 from Identification of MYC-Dependent Transcriptional Programs in Oncogene-Addicted Liver Tumors
Authors: Kress Theresia R. , Pellanda Paola , Pellegrinet Luca , Bianchi Valerio , Nicoli Paola , Doni Mirko , Recordati Camilla , Bianchi Salvatore , Rotta Luca , Capra Thelma , Ravà Micol , Verrecchia Alessandro , Radaelli Enrico , Littlewood Trevor D. , Evan Gerard I. , Amati Bruno
Published: April 2023

Genome-wide distribution and binding intensities of Myc in control and tumor samples.
Supplementary Figure 4 from Integrated Classification of Prostate Cancer Reveals a Novel Luminal Subtype with Poor Outcome
Authors: You Sungyong , Knudsen Beatrice S. , Erho Nicholas , Alshalalfa Mohammed , Takhar Mandeep , Al-deen Ashab Hussam , Davicioni Elai , Karnes R. Jeffrey , Klein Eric A. , Den Robert B. , Ross Ashley E. , Schaeffer Edward M. , Garraway Isla P. , Kim Jayoung , Freeman Michael R.
Published: April 2023

Selection of the 37-gene panel.
Supplementary Figure S3 from Identification of MYC-Dependent Transcriptional Programs in Oncogene-Addicted Liver Tumors
Authors: Kress Theresia R. , Pellanda Paola , Pellegrinet Luca , Bianchi Valerio , Nicoli Paola , Doni Mirko , Recordati Camilla , Bianchi Salvatore , Rotta Luca , Capra Thelma , Ravà Micol , Verrecchia Alessandro , Radaelli Enrico , Littlewood Trevor D. , Evan Gerard I. , Amati Bruno
Published: April 2023

MycVD induces proliferation to a similar extend as MycWT but is impaired in cellular transformation.
Table S1 from Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth
Authors: Cormerais Yann , Giuliano Sandy , LeFloch Renaud , Front Benoît , Durivault Jerome , Tambutté Eric , Massard Pierre-André , de la Ballina Laura Rodriguez , Endou Hitoshi , Wempe Michael F. , Palacin Manuel , Parks Scott K. , Pouyssegur Jacques
Published: April 2023

Table S1: Comparison of the amino acid concentrations of the media/versus human plasma.
Supplementary figure 1 from miR-182-5p Induced by STAT3 Activation Promotes Glioma Tumorigenesis
Authors: Xue Jianfei , Zhou Aidong , Wu Yamei , Morris Saint-Aaron , Lin Kangyu , Amin Samirkumar , Verhaak Roeland , Fuller Gregory , Xie Keping , Heimberger Amy B. , Huang Suyun
Published: April 2023

Supplementary figure 1
Supplemental Figures S1-S6 from Preclinical Efficacy of Bevacizumab with CRLX101, an Investigational Nanoparticle–Drug Conjugate, in Treatment of Metastatic Triple-Negative Breast Cancer
Authors: Pham Elizabeth , Yin Melissa , Peters Christian G. , Lee Christina R. , Brown Donna , Xu Ping , Man Shan , Jayaraman Lata , Rohde Ellen , Chow Annabelle , Lazarus Douglas , Eliasof Scott , Foster F. Stuart , Kerbel Robert S.
Published: April 2023

Bioluminescence imaging of mice bearing primary LM2-4 tumors (S1); Assessment of MVD, HIF-1α, and tumoral drug accumulation in PDX primary tumors (S2); Immunohistochemistry staining for CD31, CAIX, caspase 3, Ki67, and HIF-1α, as well as in vitro VEGF quantification (S3); CEUS imaging assessment of HCI-002 primary tumors (S4); Assessment of vessels with open lumen and tumor cell density in PDX tumors (S5); Time-intensity curves (TICs) of CEUS in primary MDA-MB-231/LM2-4 tumors (S6).
Suppl Table S4 from Identification of RNA-Binding Protein LARP4B as a Tumor Suppressor in Glioma
Authors: Koso Hideto , Yi Hungtsung , Sheridan Paul , Miyano Satoru , Ino Yasushi , Todo Tomoki , Watanabe Sumiko
Published: April 2023

Genomic alterations in candidate tumor suppressor genes in human glioblastoma
Supplementary Figure 4 from The Error-Prone DNA Polymerase κ Promotes Temozolomide Resistance in Glioblastoma through Rad17-Dependent Activation of ATR-Chk1 Signaling
Authors: Peng Chenghao , Chen Zhengxin , Wang Shuai , Wang Hong-Wei , Qiu Wenjin , Zhao Lin , Xu Ran , Luo Hui , Chen Yuanyuan , Chen Dan , You Yongping , Liu Ning , Wang Huibo
Published: April 2023

U87 cells were treated with 1 µM VE-821, a specific ATR inhibitor, 1 h prior to 200 µM TMZ or vehicle treatment
Supplementary Figure 3 from The Error-Prone DNA Polymerase κ Promotes Temozolomide Resistance in Glioblastoma through Rad17-Dependent Activation of ATR-Chk1 Signaling
Authors: Peng Chenghao , Chen Zhengxin , Wang Shuai , Wang Hong-Wei , Qiu Wenjin , Zhao Lin , Xu Ran , Luo Hui , Chen Yuanyuan , Chen Dan , You Yongping , Liu Ning , Wang Huibo
Published: April 2023

Western blot analysis of BRCA1, BRCA2, Rad51 and β-actin in recurrent GBM1, GBM2 and U87 cells transduced with Pol κ shRNA or control shRNA
Supplementary Figure 1 from The Error-Prone DNA Polymerase κ Promotes Temozolomide Resistance in Glioblastoma through Rad17-Dependent Activation of ATR-Chk1 Signaling
Authors: Peng Chenghao , Chen Zhengxin , Wang Shuai , Wang Hong-Wei , Qiu Wenjin , Zhao Lin , Xu Ran , Luo Hui , Chen Yuanyuan , Chen Dan , You Yongping , Liu Ning , Wang Huibo
Published: April 2023

Colony formation assay performed in recurrent GBM1 and GBM2 cells without or with different doses of TMZ
Supplemental Figure S2 from Polysome Profiling Links Translational Control to the Radioresponse of Glioblastoma Stem-like Cells
Authors: Wahba Amy , Rath Barbara H. , Bisht Kheem , Camphausen Kevin , Tofilon Philip J.
Published: April 2023

Influence of INK128 on GSC radiosensitivity
Supplementary Figures and Tables from Inflammation-Dependent IL18 Signaling Restricts Hepatocellular Carcinoma Growth by Enhancing the Accumulation and Activity of Tumor-Infiltrating Lymphocytes
Authors: Markowitz Geoffrey J. , Yang Pengyuan , Fu Jing , Michelotti Gregory A. , Chen Rui , Sui Jianhua , Yang Bin , Qin Wen-Hao , Zhang Zheng , Wang Fu-Sheng , Diehl Anna Mae , Li Qi-Jing , Wang Hongyang , Wang Xiao-Fan
Published: April 2023

Supplementary Figures S1-S16, S18, and S19 and Supplementary Tables S1-S4. Supplementary Fig. S1. Stratification of patients based on IL-18 staining density in intratumoral and peritumoral tissue. Supplementary Fig. S2. Efficient fibrosis induction by carbon tetrachloride and slightly modulated fibrosis burden between WT and IL18R1-/- mice. Supplementary Fig. S3. Multiple cell types produce IL-18 and IL18R1 in HCC. Supplementary Fig. S4. Enhanced neutrophil-to-lymphocyte ratios and decreased circulating lymphocytes in tumor-bearing IL18R1-/- mice. Supplementary Fig. S5. NK and NKT cells in liver and tumor are not significantly different between WT and IL18R1-/- mice. Supplementary Fig. S6. Myeloid cell accumulation in liver and tumor are not significantly different between WT and IL18R1-/- mice. Supplementary Fig. S7. Quantification of NK and T-cell populations in WT and IL18R1-/- mice. Supplementary Fig. S8. Representative flow cytometry of T-cell populations in non-tumor liver, tumor, and spleen in WT and IL18R1-/- mice. Supplementary Fig. S9. Alternative tumor models yield similar skewing of T-cell populations in the tumor by loss of IL18R1. Supplementary Fig. S10. Slightly increased proportions of CD44+ T-cells in IL18R1-/- mice compared to WT. Supplementary Fig. S11. No significant changes in CD4+ CD25+ cells, CD4+ FoxP3+ cells, or CD4+ CD25+ FoxP3+ cells. Supplementary Fig. S12. Modestly decreased PD-1 in CD8+ T cells in IL18R1-/- mice compared with WT mice. Supplementary Fig. S13. Slight differences in cytokine production, no differences in granzyme production in T-cells between WT and IL18R1-/- mice. Supplementary Fig. S14. Representative flow cytometry of differentiation and cytokine production of CD4+ T-cells from WT and IL18R1-/- mice. Supplementary Fig. S15. Representative flow cytometry of WT and IL18R1-/- CD8+ T-cell survival and proliferation upon reactivation and stimulation. Supplementary Fig. S16. Tumor-infiltrating NK cells have altered cytokine and transcription factor production between WT and IL18R1-/- mice. Supplementary Supplementary Fig. S18. Differences in IL-18 staining density between intratumoral and peritumoral tissue are more closely linked to peritumoral staining density. Supplementary Fig. S19. No difference in survival based on expression of IL18R1 in patient samples. Supplementary Table S1. Antibodies, Dyes, Stains, and Recombinant Proteins Used. Supplementary Table S2. qPCR Primers and shRNAs Used. Supplementary Table S3. Correlations between Patient Characteristics and Phenotypes and IL-18 Staining Density in Our 138 Patient Cohort. Supplementary Table S4. Average Density of Intratumoral and Peritumoral IL-18 Staining in Our 138 Patient Cohort.
Supplementary Figure S3 from Multiple Myeloma Impairs Bone Marrow Localization of Effector Natural Killer Cells by Altering the Chemokine Microenvironment
Authors: Ponzetta Andrea , Benigni Giorgia , Antonangeli Fabrizio , Sciumè Giuseppe , Sanseviero Emilio , Zingoni Alessandra , Ricciardi Maria Rosaria , Petrucci Maria Teresa , Santoni Angela , Bernardini Giovanni
Published: April 2023

Supplementary Figure S3. CXCR3 expression on BM or PB NK cells from patients with MGUS, Smoldering (SMO), Onset and Relapse
Supplementary Tables from Combined VEGF and PD-L1 Blockade Displays Synergistic Treatment Effects in an Autochthonous Mouse Model of Small Cell Lung Cancer
Authors: Meder Lydia , Schuldt Philipp , Thelen Martin , Schmitt Anna , Dietlein Felix , Klein Sebastian , Borchmann Sven , Wennhold Kerstin , Vlasic Ignacija , Oberbeck Sebastian , Riedel Richard , Florin Alexandra , Golfmann Kristina , Schlößer Hans A. , Odenthal Margarete , Buettner Reinhard , Wolf Juergen , Hallek Michael , Herling Marco , von Bergwelt-Baildon Michael , Reinhardt H. Christian , Ullrich Roland T.
Published: April 2023

Clinicopathologic parameters of mice and patients with the corresponding survival significance analysis of SCLC bearing mice treated with vehicle, IgG control, anti-VEGF monotherapy, anti-PD-L1 monotherapy or anti-VEGF/anti-PD-L1 combination therapy
Table S3 from Upregulated Glucose Metabolism Correlates Inversely with CD8+ T-cell Infiltration and Survival in Squamous Cell Carcinoma
Authors: Ottensmeier Christian H. , Perry Kate L. , Harden Elena L. , Stasakova Jana , Jenei Veronika , Fleming Jason , Wood Oliver , Woo Jeongmin , Woelk Christopher H. , Thomas Gareth J. , Thirdborough Stephen M.
Published: April 2023

Table S3. Complete list of identified modules in the SCC consensus network and their top GO Biological Process category.
Figure S4 from Upregulated Glucose Metabolism Correlates Inversely with CD8+ T-cell Infiltration and Survival in Squamous Cell Carcinoma
Authors: Ottensmeier Christian H. , Perry Kate L. , Harden Elena L. , Stasakova Jana , Jenei Veronika , Fleming Jason , Wood Oliver , Woo Jeongmin , Woelk Christopher H. , Thomas Gareth J. , Thirdborough Stephen M.
Published: April 2023

Figure S4. Pathway and survival analysis of genes negatively associated with the leukocyte module (M1) eigengene. (A) Each module whose eigengene inversely correlated with ME1 were represented as a node connected to some of the top-ranked genes (adj.P< 0.01) of each module that share enriched pathways. (B) Kaplan-Meier estimates of overall survival among patients grouped according to expression of a glycolytic gene signature (listed Fig. 4E).
Supplementary Methods from p27 Is a Candidate Prognostic Biomarker and Metastatic Promoter in Osteosarcoma
Authors: Li Yiting , Nakka Manjula , Kelly Aaron J. , Lau Ching C. , Krailo Mark , Barkauskas Donald A. , Hicks John M. , Man Tsz-Kwong
Published: April 2023

Detailed method descriptions of Autoantibody Profiling, ProtoPlex Immune Response Assay to Measure the p27 Autoantibody, Western Blotting, RHOA Activation Assay, Quantitative Reverse-transcription PCR of p27, Cell Growth Assay, Sequences of the two p27-specific shRNAs.
Figure S5 from TGFβ Signaling in the Pancreatic Tumor Microenvironment Promotes Fibrosis and Immune Evasion to Facilitate Tumorigenesis
Authors: Principe Daniel R. , DeCant Brian , Mascariñas Emman , Wayne Elizabeth A. , Diaz Andrew M. , Akagi Naomi , Hwang Rosa , Pasche Boris , Dawson David W. , Fang Deyu , Bentrem David J. , Munshi Hidayatullah G. , Jung Barbara , Grippo Paul J.
Published: April 2023

Figure S5. KRAS and KTE mice have intact T Cell TGFbe Signaling
Supplementary Figure S7 from Heparanase 2 Attenuates Head and Neck Tumor Vascularity and Growth
Authors: Gross-Cohen Miriam , Feld Sari , Doweck Ilana , Neufeld Gera , Hasson Peleg , Arvatz Gil , Barash Uri , Naroditsky Inna , Ilan Neta , Vlodavsky Israel
Published: April 2023

Over expression of Id1 in Hpa2 clones results in bigger and necrotic tumors.
Supplementary Figure S4 from Heparanase 2 Attenuates Head and Neck Tumor Vascularity and Growth
Authors: Gross-Cohen Miriam , Feld Sari , Doweck Ilana , Neufeld Gera , Hasson Peleg , Arvatz Gil , Barash Uri , Naroditsky Inna , Ilan Neta , Vlodavsky Israel
Published: April 2023

Comparable Hpa2 levels in FaDu cell clones and patients' biopsies.
Supplemental Figure 4 FIP1C is a negative modulator of Akt and MAPK activation in an ErbB2-driven model from Rab11-FIP1C Is a Critical Negative Regulator in ErbB2-Mediated Mammary Tumor Progression
Authors: Boulay Pierre-Luc , Mitchell Louise , Turpin Jason , Huot-Marchand Julie-Émilie , Lavoie Cynthia , Sanguin-Gendreau Virginie , Jones Laura , Mitra Shreya , Livingstone Julie M. , Campbell Shirley , Hallett Michael , Mills Gordon B. , Park Morag , Chodosh Lewis , Strathdee Douglas , Norman Jim C. , Muller William J.
Published: April 2023

The Supplemental Figure 4 consists in key additionnal data sets to support and supplement Figure 5. Briefly, this supplemental figure 4 shows immunohistochemistry staining performed on FIP1C-MTB-NDL and NIC/FIP1C mammary tumors to examine activation of key component of ErbB2 signaling. Our results indicates that induction of FIP1C decreases endogenous level of P-Erk1/2 and FASN. In contrast, deletion of FIP1C significantly increases P-Erk1/2 and FASN.
Supplementary Figure 3 from Stress Chaperone Mortalin Contributes to Epithelial-to-Mesenchymal Transition and Cancer Metastasis
Authors: Na Youjin , Kaul Sunil C. , Ryu Jihoon , Lee Jung-Sun , Ahn Hyo Min , Kaul Zeenia , Kalra Rajkumar S. , Li Ling , Widodo Nashi , Yun Chae-Ok , Wadhwa Renu
Published: April 2023

Mortalin overexpressing cells showed increase in microfilaments.
Supplementary Figure 1 from A Chimeric Switch-Receptor Targeting PD1 Augments the Efficacy of Second-Generation CAR T Cells in Advanced Solid Tumors
Authors: Liu Xiaojun , Ranganathan Raghuveer , Jiang Shuguang , Fang Chongyun , Sun Jing , Kim Soyeon , Newick Kheng , Lo Albert , June Carl H. , Zhao Yangbing , Moon Edmund K.
Published: April 2023

Schematic of lentiviral and retroviral expression plasmids.
Supplementary Materials and Methods from Novel ß-HPV49 Transgenic Mouse Model of Upper Digestive Tract Cancer
Authors: Viarisio Daniele , Müller-Decker Karin , Zanna Paola , Kloz Ulrich , Aengeneyndt Birgit , Accardi Rosita , Flechtenmacher Christa , Gissmann Lutz , Tommasino Massimo
Published: April 2023

Additional information of methods used in the study
Supplementary Figure 2 from Novel ß-HPV49 Transgenic Mouse Model of Upper Digestive Tract Cancer
Authors: Viarisio Daniele , Müller-Decker Karin , Zanna Paola , Kloz Ulrich , Aengeneyndt Birgit , Accardi Rosita , Flechtenmacher Christa , Gissmann Lutz , Tommasino Massimo
Published: April 2023

E6/E7 gene copy number and E6/E7 transcript levels in the different HPV Tg animal models.
Supplemental Figure S6 from Histone Deacetylase HDAC8 Promotes Insulin Resistance and β-Catenin Activation in NAFLD-Associated Hepatocellular Carcinoma
Authors: Tian Yuan , Wong Vincent W.S. , Wong Grace L.H. , Yang Weiqin , Sun Hanyong , Shen Jiayun , Tong Joanna H.M. , Go Minnie Y.Y. , Cheung Yue S. , Lai Paul B.S. , Zhou Mingyan , Xu Gang , Huang Tim H.M. , Yu Jun , To Ka F. , Cheng Alfred S.L. , Chan Henry L.Y.
Published: April 2023

HDAC8 activates Î²-catenin signaling to promote hepatocellular growth.
Supplementary Materials and Methods from Infiltrating Macrophages Induce ERα Expression through an IL17A-mediated Epigenetic Mechanism to Sensitize Endometrial Cancer Cells to Estrogen
Authors: Ning Chengcheng , Xie Bingying , Zhang Lin , Li Chunsheng , Shan Weiwei , Yang Bingyi , Luo Xuezhen , Gu Chao , He Qizhi , Jin Hongyan , Chen Xiaojun , Zhang Zhenbo , Feng Youji
Published: April 2023

Supplementary Materials and Methods and Supplementay Figure legends
Figure S2 from UGT2B17 Expedites Progression of Castration-Resistant Prostate Cancers by Promoting Ligand-Independent AR Signaling
Authors: Li Haolong , Xie Ning , Chen Ruiqi , Verreault Mélanie , Fazli Ladan , Gleave Martin E. , Barbier Olivier , Dong Xuesen
Published: April 2023

Figure S2: Androgen deprivation increased LNCaP(UGT2B17) glucuronidation activity
Supplementary Table 7 from Landscape of Combination Immunotherapy and Targeted Therapy to Improve Cancer Management
Authors: Colli Leandro M. , Machiela Mitchell J. , Zhang Han , Myers Timothy A. , Jessop Lea , Delattre Olivier , Yu Kai , Chanock Stephen J.
Published: April 2023

Copy-number, expression and mutation comparision for MET, ERBB2, PTEN, NF2
Supplementary Table S5 from High-Order Drug Combinations Are Required to Effectively Kill Colorectal Cancer Cells
Authors: Horn Thomas , Ferretti Stéphane , Ebel Nicolas , Tam Angela , Ho Samuel , Harbinski Fred , Farsidjani Ali , Zubrowski Matthew , Sellers William R. , Schlegel Robert , Porter Dale , Morris Erick , Wuerthner Jens , Jeay Sébastien , Greshock Joel , Halilovic Ensar , Garraway Levi A. , Caponigro Giordano , Lehár Joseph
Published: April 2023

Data for characterization of triple combination targeting MDM2, MEK, and BCL-2/-XL.
Figure S3 from Deletion of Lactate Dehydrogenase-A in Myeloid Cells Triggers Antitumor Immunity
Authors: Seth Pankaj , Csizmadia Eva , Hedblom Andreas , Vuerich Marta , Xie Han , Li Mailin , Longhi Maria Serena , Wegiel Barbara
Published: April 2023

LDH-A in macrophages controls expression of HO-1.
Supplementary Figure S3 from HER2 and EGFR Overexpression Support Metastatic Progression of Prostate Cancer to Bone
Authors: Day Kathleen C. , Hiles Guadalupe Lorenzatti , Kozminsky Molly , Dawsey Scott J. , Paul Alyssa , Broses Luke J. , Shah Rajal , Kunja Lakshmi P. , Hall Christopher , Palanisamy Nallasivam , Daignault-Newton Stephanie , El-Sawy Layla , Wilson Steven James , Chou Andrew , Ignatoski Kathleen Woods , Keller Evan , Thomas Dafydd , Nagrath Sunitha , Morgan Todd , Day Mark L.
Published: April 2023

FACS gating and the role of RANK expression on prostate sphere formation.
Supplementary Data from HER2 and EGFR Overexpression Support Metastatic Progression of Prostate Cancer to Bone
Authors: Day Kathleen C. , Hiles Guadalupe Lorenzatti , Kozminsky Molly , Dawsey Scott J. , Paul Alyssa , Broses Luke J. , Shah Rajal , Kunja Lakshmi P. , Hall Christopher , Palanisamy Nallasivam , Daignault-Newton Stephanie , El-Sawy Layla , Wilson Steven James , Chou Andrew , Ignatoski Kathleen Woods , Keller Evan , Thomas Dafydd , Nagrath Sunitha , Morgan Todd , Day Mark L.
Published: April 2023

Supplemental materials, methods and figure legends.
Supplementary Figure S4 from Preclinical Evidence That 3′-Deoxy-3′-[18F]Fluorothymidine PET Can Visualize Recovery of Hematopoiesis after Gemcitabine Chemotherapy
Authors: Schelhaas Sonja , Held Annelena , Bäumer Nicole , Viel Thomas , Hermann Sven , Müller-Tidow Carsten , Jacobs Andreas H.
Published: April 2023

Preliminary analysis of other thymidine metabolism proteins did not indicate their involvement in changes in [18F]FLT in hematopoietic compartments after gemcitabine therapy.
Supplementary Figure S7. Effect of EO771-derived exosome conditioning on immune composition in the spleen. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes
Authors: Wen Shu Wen , Sceneay Jaclyn , Lima Luize Goncalves , Wong Christina S.F. , Becker Melanie , Krumeich Sophie , Lobb Richard J. , Castillo Vanessa , Wong Ke Ni , Ellis Sarah , Parker Belinda S. , Möller Andreas
Published: April 2023

C57BL/6 mice were injected intravenously with 10 μg (7.8E10 particles) of EO771 exosomes or liposomes every three days for 30 days. Immune composition changes in the spleen was assessed at endpoint by flow cytometry. Frequency of (A) CD4 (CD3/CD4+) and CD8 T-cells (CD3+/CD8+), (B) NK cells (NK1.1+/CD3-), (C) CD11b+/Ly6Chigh monocytic MDSCs and CD11b+/Ly6Cmed granulocytic MDSCs, (D) dendritic cells (CD11C+/MHCII+) and (E) macrophages (mø; CD11b+/F4/80+). Results are presented as mean {plus minus} s.e.m. (n=9-10 animals/group) and analyzed by 2-tailed Mann-Whitney U-tests, and Holm-Sidak multiple testing correction method; *: p<0.05.
Supplementary Figure S6. Changes in immune cell numbers in the lung after continuous conditioning with EO771 breast cancer exosomes. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes
Authors: Wen Shu Wen , Sceneay Jaclyn , Lima Luize Goncalves , Wong Christina S.F. , Becker Melanie , Krumeich Sophie , Lobb Richard J. , Castillo Vanessa , Wong Ke Ni , Ellis Sarah , Parker Belinda S. , Möller Andreas
Published: April 2023

C57BL/6 mice were injected intravenously with 10 μg (7.8E10 particles) of EO771 exosomes or liposomes every three days for 30 days. The number of cells per gram lung tissue of various immune cell populations in the lung was quantified by flow cytometry at endpoint: (A) CD45+ cells, (B) CD4 (CD3/CD4+) and CD8 T-cells (CD3+/CD8+), (C) NK cells (NK1.1+/CD3-), (D) dendritic cells (CD11C+/MHCII+), (E) macrophages (mø; CD11b+/F4/80+), and (F) CD11b+/Ly6Chigh monocytic MDSCs and CD11b+/Ly6Cmed granulocytic MDSCs. (G) Ratio of CD8+ T-cells to gMDSCs (CD11b+/Ly6Cmed) in the lung. Results are presented as mean {plus minus} s.e.m. (n=8-9 animals/group) and analyzed by 2-tailed Mann-Whitney U-tests, and Holm-Sidak multiple testing correction method; *: p<0.05.
Supplementary Figure Legends from Preclinical Evidence That 3′-Deoxy-3′-[18F]Fluorothymidine PET Can Visualize Recovery of Hematopoiesis after Gemcitabine Chemotherapy
Authors: Schelhaas Sonja , Held Annelena , Bäumer Nicole , Viel Thomas , Hermann Sven , Müller-Tidow Carsten , Jacobs Andreas H.
Published: April 2023

Legends for supplementary figures.
Supplementary Figure S2. Whole body tracking of fluorescently-labeled EO771 breast cancer exosomes. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes
Authors: Wen Shu Wen , Sceneay Jaclyn , Lima Luize Goncalves , Wong Christina S.F. , Becker Melanie , Krumeich Sophie , Lobb Richard J. , Castillo Vanessa , Wong Ke Ni , Ellis Sarah , Parker Belinda S. , Möller Andreas
Published: April 2023

Representative whole body fluorescent images of C57BL/6 mice at 4, 24 and 48-hours post-intravenous injection of Vybrant® DiD-labeled EO771 exosomes (20 µg; 1.6E11 particles) or liposomes at equivalent particle numbers using the IVIS® Spectrum (PerkinElmer) (n=5/group).
Figure S1 from Beta-Blocker Drug Use and Survival among Patients with Pancreatic Adenocarcinoma
Authors: Udumyan Ruzan , Montgomery Scott , Fang Fang , Almroth Henrik , Valdimarsdottir Unnur , Ekbom Anders , Smedby Karin E. , Fall Katja
Published: April 2023

Study population selection process