bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Empowerment on Perceived Person-Environment Fit and Work Engagement: Focusing on Online Travel Platform Employees
Authors:   IAGBT, Um Ji-Young , Park Hye-Yeon , Yoon Sun-Young
Published: February 2023

Purpose - COVID-19 has dramatically changed the business landscape, and the travel industry is no exception. The industry is undergoing a paradigm shift to the platform business, and traditional travel agencies are moving their businesses to online platforms. However, in this irreversible global paradigm shift, it is not easy for travel companies to hire and retain employees, especially companies in the IT sector. Studies typically study consumers, such as selection attributes and satisfaction with travel platforms. However, to the best of our knowledge, there have been almost no studies on employees. This study explored how the empowerment of online travel platform employees influences their perceived person-environment (P-E) fit and work engagement.
Design/Methodology/Approach - We analyzed data from 352 employees of 26 domestic online travel platforms who were surveyed in January and February 2021. After coding the collected data, we analyzed it using frequency, exploratory factor, reliability, correlation, and multiple regression analyses using IBM SPSS Statistics, ver. 20.0.
Findings - First, enhancing the meaningfulness of work and organizational autonomy influences personjob (P-J) fit and person-organization (P-O) fit. Second, enhancing the meaningfulness of work significantly influences vigor, dedication, and absorption in terms of work engagement, while organizational autonomy significantly influences work engagement vigor. Third, P-J fit and P-O fit influence the vigor of work engagement, and P-O fit influences dedication and absorption.
Research Implications - This study demonstrated that the empowerment of travel platform employees can improve perceived P-E fit and work engagement. Thus, if organizations guarantee some degree of empowerment, employees will be energized and engaged more in their workplace. Finally, this helps expand the scope of online travel platform research from the perspective of personnel organization.
Vascularized lymph node transfer for the treatment of lymphedema: a systematic review and meta-analysis of clinical and patient-reported outcomes
Authors: Raman Shreya , Sanka Sai Anusha , Ji Jenny , Yaeger Lauren , Skolnick Gary B. , Christensen Joani M.
Published: February 2023

Aim: The aim of this systematic review was to summarize clinical and patient-reported outcomes (PROs) for various vascularized lymph node transfer (VLNT) donor sites and identify gaps in the literature to guide future research. Methods: A literature search of five databases was performed for articles related to VLNT that were published prior to November 2021. Studies that included clinical outcomes or PROs from at least five adult patients who received VLNTs to treat lymphedema were included. Results: Sixty-six studies met the study criteria. Most studies reported improved limb circumference/volume, reduction or discontinuation of conservative therapy, infection rate reduction, improved PROs, or postoperative imaging findings reflecting functional lymph nodes. There were significantly lower infection rates (P < 0.05) and a trend towards improved PROs in patients who received intra-abdominal flaps, but overall few studies reported these outcomes. There were no significant differences in complication rates at the donor or recipient site based on VLNT donor sites, or between intra-abdominal vs. extra-abdominal VLNT donor sites, although these outcomes are not uniformly reported. Conclusion: This meta-analysis identified that intra-abdominal donor sites have the potential to reduce postoperative infectious episodes more than extra-abdominal donor sites. Though recent investigations address many understudied VLNT donor sites, larger comparative studies and a standardized methodology are needed to better characterize postoperative outcomes, which can offer more concrete evidence to guide surgical practice.
Mersin’de ilköğretim birinci sınıfa giden erkek öğrencilerde inmemiş testis sıklığının araştırılması
Authors: BUĞDAYCI Resul , İSBİR Caner , BOZDAĞ Fatma , SOLMAZ Elif Tuğçe
Published: February 2023

Amaç: Mersin İl merkez ilçelerinde ilkokul birinci sınıf öğrencilerde inmemiş testis sıklığını saptamak.

Yöntem: Kesitsel tipte planlanan çalışma Mersin ili merkezinde bulunan ve basit rastgele yöntemle seçilen 22 ilkokulda yürütülmüştür. Ailesi yazılı onay veren 776 1. Sınıf erkek öğrencinin verisi analiz edildi. Muayeneler okullarında hazırlanan bir muayene odasında, araştırmacı hekim tarafından yapıldı. İnmemiş ya da retraktil testis ön tanı konulan 52 öğrenci Çocuk Cerrahisi kliniğine gönderilerek tanısı kesinleştirildi. Endikasyonu olan 24 öğrenciye orşidopeksi ameliyatı yapıldı. Verilerin özetlenmesinde tanımlayıcı istatistikler, değişkenlerin karşılaştırılmasında ki-kare testi kullanılmış, anlamlılık düzeyi p≤0.05 olarak alınmıştır.

Bulgular: Araştırmaya alınan 776 öğrencinin %84.1’i Türk, %15.9’u yabancı uyrukluydu. 776 öğrencinin doğrulama muayenelerinden sonra %96.3’ü normal, %2.3’üne inmemiş %1.4’üne retraktil testis tanısı konuldu. Bu öğrencilerin %65.5’i son bir yıl içinde herhangi bir sebeple bir hekime başvurmuşlardı. Yabancı uyruklu öğrencilerde inmemiş ya da retraktil testis sıklığı (%7.3), Türk uyruklu öğrencilere göre (%3.1) daha yüksekti (p
Una contribución a la economía circular: cenizas volantes de incineración de residuos sólidos urbanos para producir aglutinantes ecológicos = A contribution to the circular economy: municipal solid waste incineration fly ash to produce eco-friendly binders
Authors: Marieta Cristina , Martín-Garín Alexander , León Iñigo , Guerrero Ana
Published: February 2023

Los residuos sólidos urbanos son uno de los problemas medioambientales más acuciantes a los que se enfrenta el mundo. Hoy en día, la incineración se considera la tecnología más eficaz para tratarlos. Sin embargo, tras el proceso de incineración, cerca del 25% de la masa total inicial de residuos son cenizas, que deben eliminarse en vertederos. Las tendencias recientes sugieren que es posible seguir avanzando en la eficiencia de los recursos convirtiendo los residuos en un recurso y cerrando así el ciclo en una economía circular. Las cenizas volantes pueden utilizarse como sustituto de los recursos naturales en la construcción, como áridos o en la fabricación de nuevos materiales. En particular, estas cenizas volantes contienen elementos como Ca, Si y Al, que permiten su utilización como materia prima para la fabricación de ligantes. En el presente trabajo, se presentarán los resultados obtenidos a partir de la caracterización fisicoquímica de las cenizas volantes. El objetivo de la investigación es explorar la viabilidad del uso de estas cenizas volantes como materia prima en la fabricación de ligantes ecológicos.AbstractMunicipal solid waste is one of the most pressing environmental problems the world faces. Nowadays, incineration is considered to be the most effective technology for treating it. However, after the incineration process, close to 25% of the initial total mass of waste is ash, which has to be placed of in landfills. Recent trends suggest that further progress in resource efficiency is possible by turning waste into a resource and thus closing the loop in a circular economy. Fly ash can be utilized as a substitute for natural resources in construction, as in aggregates or in the manufacture of new materials. In particular, these fly ashes contain elements such as Ca, Si and Al, which make it possible for them to be used as a raw material to manufacture binders. In the present work, the results obtained from the physicochemical characterization of fly ashes will be presented. The research aims to explore the feasibility of using this fly ash as raw material in the manufacture of eco-friendly binders.
Spiritual Guidance With Dhikr Therapy for People with Mental Disorders (Analysis of the Implementation of Spiritual Guidance With Dhikr Therapy at the Jalma Sehat Kudus Foundation)
Authors: Bastomi Hasan
Published: February 2023

This study aims to reveal the implementation of spiritual guidance with dhikr therapy for people with mental disorders at the Jalma Sehat Kudus Foundation. The research on the implementation of spiritual guidance with dhikr therapy in people with mental disorders was carried out using a qualitative approach with the type of field research with data collection techniques using Interview, Observation and Documentation. The results showed that first, the method of Islamic spiritual guidance with dhikr therapy in dealing with people with mental disorders at the Jalma Sehat Kudus Foundation is the group therapy method and the direct therapy method. Second, there are two stages in the implementation of Islamic spiritual guidance with dhikr therapy in dealing with mental disorders patients at the Jalma Sehat Kudus Foundation, namely: (1) The preparation stage, is the stage where the supervisor assisted by nurses identifies problems, designs action plans, and solves problems. patient problems. (2) The implementation stage, namely by reading dhikr sentences such as tasbih, istigfhar, and sholawat sentences. Third, the material in Islamic spiritual guidance with dhikr therapy is an explanation of the nature of God, human duties, commendable and despicable morals, and gratitude. The implication of this research is to provide knowledge about the implementation of dhikr therapy, because dhikr based on various studies can help overcome mental disorders.
Plan de negocio elaboración artesanal de macerados de frutas secas en pisco en la ciudad de Lima
Authors:   , Espinoza Cueva Evgueni , Ramos Prado Hebert Alfonso , Benites Gerstein Ingrid Brigitte
Published: February 2023

Nuestro plan de negocio tiene como finalidad, incluir los macerados de pisco en base a frutas secas como: pasas, guindones, damasco y toronja dentro del mercado peruano, en la cual destacamos nuestro proceso de elaboración obteniendo en un principio la materia prima que es el pisco quebranta proveniente de Ica, en la cual, se ha podido obtener el proveedor más eficiente, es así como se inicia la elaboración y reposo del pisco en conjunto con los frutos por plazo determinado, el cual nos deleitará con su nuevo aroma y sabor de gran calidad en los almacenes de ACHIRANA ubicados en San Luis y Lince, para proceder con el embotellamiento y tiempo de distribución de los macerados a nivel local y así poner el nombre ACHIRANA, como un producto reconocido del mercado de los derivados del pisco peruano.
Relación entre calidad de vida laboral y nivel de estrés en personal de enfermería en contexto Covid-19 en un centro de salud de Lima
Authors:   , Cule Zambrano Elizabeth , Nuñez Santiago Carlos Alberto
Published: February 2023

La calidad de vida laboral implica muchos factores como condiciones físicas, sociales y psicológicas; enfocándose en el bienestar y satisfacción de los trabajadores, así como en el efecto en la productividad y calidad de servicios. El personal de enfermería corre mayor riesgo de contagio en la batalla contra la pandemia del COVID-19. por brindar atención en primera línea. Objetivo: establecer relación entre calidad de vida laboral y nivel de estrés en el personal de enfermería en contexto COVID-19 en un establecimiento de salud de Lima. Metodología: el estudio fue tipo aplicado, no experimental, cuantitativo, de nivel relacional y corte transversal; los instrumentos utilizados fueron el “Inventario de Maslach Burnout Inventory” y el “Cuestionario de Calidad de Vida Laboral” aplicados a una población de 38 técnicos y 26 licenciados en enfermería. Resultados: Los hallazgos muestran un nivel alto de estrés laboral (81.3%) y nivel medio (18.8%), asimismo el 79.7% del personal de enfermería tiene buena calidad de vida laboral. De acuerdo a la prueba Chi-cuadrado existe una relación estadística significativa entre las variables (χ²= 28.203; p<0,001), asimismo, se determinó intensidad alta en la asociación mediante la prueba gamma (gamma=0.632 y p<0,001); de igual modo se determinó la direccionalidad de la asociación mediante la prueba de D de somers (D de sommers=0.450 y p<.001); por consiguiente, existe nivel medio de predicción de la variable nivel de estrés hacia calidad de vida laboral. Conclusión: se concluye que, existe relación entre calidad de vida laboral y nivel de estrés en el personal de enfermería.
Clima laboral y estrés en un call center, distrito de San Borja (Lima-Perú), 2022
Authors:   , Tapia Quispe Mario Fernando
Published: February 2023

Con el presente trabajo de investigación titulado “Clima laboral y estrés en un call center, distrito de San Borja (Lima – Perú), 2022”, se buscó determinar la relación entre el clima laboral y el estrés en un call center, distrito de San Borja (Lima – Perú), 2022. La metodología se desarrolló bajo un estudio no experimental, transversal, correlacional-causal, de enfoque cuantitativo, con una muestra censal de 50 colaboradores. Se usó la técnica de la encuesta y el instrumento fue el cuestionario. Los resultados mostraron el cumplimiento de la hipótesis nula, es decir, que no existe relación entre ambas variables con un nivel de significancia de 0.106. La conclusión fue que no se cumplió el objetivo y se determinó que no existió relación entre el clima laboral y el estrés en un call center, distrito de San Borja (Lima – Perú), 2022. Análogamente, no existió relación entre el estrés laboral y dos de las dimensiones del clima laboral: condiciones laborales y trabajo en equipo, pero en la dimensión de desarrollo laboral si existe una relación, pero débil.
Efectividad de la terapia mindfulness en el control de la presión arterial en los adultos hipertensos de un centro de salud, Lima - 2021
Authors:   , Chonta Jaime Edith Karina , Cortez Portas Neydi Guicela
Published: February 2023

Terapia Mindfulness, una medida complementaria que mostrará la alternativa ideal al problema de hipertensión arterial. Este estudio tuvo el objetivo determinar la efectividad de la terapia Mindfulness en el control de la presión arterial en los adultos hipertensos de un centro de salud, Lima - 2021. Metodología: diseño pre - post, enfoque cuantitativo y de cohorte longitudinal. Se utilizó la fórmula estadística Mcnemar, aplicado en el C.S. de Villa El Salvador, Lima - Perú. Se empleo el cuestionario Escala de estrés, depresión y ansiedad (DASS 21). Resultados: la presión arterial predominó en el sexo femenino con el 64% entre las edades de 50 a 59 años. Se tomo la presión arterial antes y después de la terapia Mindfulness a 50 adultos donde el 64% se clasificaba en prehipertensos y posterior a la terapia el 72% pasó a PA normal. Los factores confusores también llegaron a disminuir alcanzando el nivel del estrés al 42%, ansiedad 38% y depresión 64%. Conclusión: se determinó que la terapia Mindfulness fue efectiva en el control de la presión arterial y los factores confusores no influyen en dichos resultados.
An adaptive fuzzy semi-parametric regression model using TPB and ABC-BPNN
Authors: Jiang Keli , Lu Qiujun
Published: February 2023

In this paper, a new hybrid method is developed that incorporates the rationale of truncated power basis (TPB) and artificial bee colony-back propagation neural networks (ABC-BPNN) into an adaptive fuzzy semi-parametric regression model yielding more accurate results and better generalization ability. The proposed adaptive fuzzy semi-parametric regression model comprises sub-model formulation and approximates the observed fuzzy outputs from the outside employing neural networks computation, such that the proposed adaptive fuzzy regression model better explains the inherent dependence and vagueness that exist in a given dataset. Using the cross-validation criterion and absolute deviation-based distance measures for LR-type fuzzy numbers, a target function optimization problem of constructing the adaptive fuzzy semi-parametric regression is performed by solving the smooth function, bandwidth of kernel function and regression coefficients. This strategy significantly increases the goodness of fit for the proposed algorithm and offers a dependence framework among magnitude and uncertainty for the fuzzy regression model. We also use three formula measures to evaluate the fit quality of the regression results within each membership function as well as in the center or spread tendency property, respectively. The proposed algorithm is numerically evaluated on three experimental examples including a simulation study and two practical cases to prove its practicality and efficiency. Comparative analyses of our proposed method are provided in order to support its cogency, and the results show that our proposed model is more effective and stable than some other existing fuzzy regressions.
Modulation of lytic molecules restrain serial killing in γδ T lymphocytes
Authors: Onfelt Bjorn , Sandoz Patrick , Kuhnigk Kyra , Szabo Edina , Thunberg Sarah , Erikson Elina , Sandström Niklas , Verron Quentin , Brech Andreas , Watzl Carsten , Wagner Arnika , Alici Evren , Malmberg Karl-Johan , Uhlin Michael
Published: February 2023

Vγ9Vδ2 is the largest γδ T cell subset in human peripheral blood. These cells get activated and proliferate in response to phosphoantigens produced by infected or tumour transformed cells. Although Vγ9Vδ2 T cells have shown evidence of innate-like cytotoxicity, their modus operandi remains poorly understood. In this work, we have used single-cell imaging in microwells to track the dynamics and cytotoxic functions of Vγ9Vδ2 T cells upon interactions with tumour target cells under different stimuli and phases of expansion. While Vγ9Vδ2 T cell killing was dominated by degranulation, the availability of lytic molecules appeared tightly regulated in time and space. In particular, granzyme B was abundant but its limited co-occurrence with perforin restrained serial killing of tumour cells. Altogether, our data provide new insights into the Vγ9Vδ2 T cell cytotoxic arsenal and functions, which can guide the development of more efficient γδ T cell based adoptive immunotherapies.
Facile synthesis of NaA zeolite supported Co2Fe1 for highly efficient degradation of Acid Orange 7 by activation of peroxymonosulfate
Authors: Xu Yue , Liu Jian , Zhao Yi , Yi Zhengji
Published: February 2023

The development of heterogeneous Co-based catalysts with an effective combination mode of Co/Fe and supporter, a facile synthetic method, and a low treatment costs is an important environment challenge for azo dyes degradation by peroxymonosulfate (PMS) activation. In this study, NaA zeolite supported CoxFey with various molar ratio of Fe/Si and Co/Fe was synthesized by a facile hydrothermal process, and used to activate PMS for Acid Orange 7 (AO7) degradation. NaA zeolite supported Co2Fe1 with the Fe/Si molar ratio of 1:10 showed superior catalytic performance compared with other NaA zeolite supported CoxFey. In a system containing 0.6 g/L catalysts, 4 mM PMS, pH 5 and T = 30℃, 95.8% AO7 and 79.1% COD conversion could be achieved at 20 and 60 min, respectively, and the first order kinetic rate constant reached 0.14795 min− 1. Moreover, NaA zeolite supported Co2Fe1/PMS system exhibited excellent catalytic effect in a wide pH range of 3–9. Temperature had an obvious effect on AO7 degradation, and the activation energy was 31.36 kJ/mol. HCO3− demonstrated an obvious depression on AO7 degradation, while Cl−, SO42− and H2PO4− had a relatively poor impact. Quenching experiments showed that both sulfate radicals (SO4•-) and hydroxyl radicals (·OH) were generated in the PMS reaction system, and the (SO4•-) was the dominant active radical. During 3 cycles experiments, an acceptable AO7 conversion ratio (91.8%) within 30 min was arrived, suggesting the good stability of NaA zeolite supported Co2Fe1.
Feticide Before Termination of Pregnancy in Singleton Pregnancy – Trends in England and Wales 2012-2020, a cross-sectional study
Authors: Schiff Isabelle , Shangaris Panicos , Grinsted Mary , Sankaran Srividhya
Published: February 2023

Aim
Feticide is the practice of inducing fetal demise before termination of pregnancy. In England and Wales, it is recommended for terminations of pregnancy beyond 21 + 6 weeks of gestation. This project analyses the trends in feticide in singleton pregnancy in England and Wales between 2012 and 2020.
Methods
This project was a retrospective study that analysed data extracted from the Health and Social Act 4 (HSA4) forms submitted to the Department of Health and Social Care (DHSC). The data extracted by the DHSC included the prevalence of feticide, methods of feticide and termination, statutory grounds, gestation, service provider, maternal age, ethnicity, and obstetric history. In addition, data analysis was carried out to identify trends.
Results
Between 2012 and 2020, there were 9310 feticides in England and Wales, used in 0.5% of all abortions. The prevalence of feticide fluctuated however, there was an overall decrease from 1084 cases in 2012 to 1000 cases in 2020. The most common method was intracardiac injection of potassium chloride (67.2%). Most feticides were performed before medical abortions (58.0%). 55.8% of feticides took place under Ground E of the Abortion Act 1967, and the main indication was congenital malformations of the nervous system. Most feticides occurred at 23 weeks gestation (40.2%) and in NHS hospitals (60.3%). Women undergoing feticide were mostly aged 30–34 years (38.3%) and of White ethnicity (78.6%).
Conclusion
Feticide is an essential component of comprehensive abortion care for women undergoing late second and third-trimester abortions. This study provides insight into how feticide is carried out in England and Wales and demonstrates the effect of the Covid-19 pandemic on feticide prevalence. Future research should analyse in more detail the use of the different methods of feticide.
Analysis of Tetrabromobisphenol A and Bisphenol A in Plant Sample-Method Optimization and Identification of the Derivatives
Authors: Xu Xuehui , Han Wei
Published: February 2023

Tetrabromobisphenol A (TBBPA) is the most abundant brominated flame retardant and bisphenol A (BPA) is often identified as the metabolism of TBBPA. Both of them are highly bioconcentrated and show serious biological toxicity. In this study, an analytical method was optimized to simultaneously determine TBBPA and BPA in plant samples. Moreover, the uptake and metabolism of TBBPA in maize was investigated through hydroponic exposure experiment. The whole analysis procedure included ultrasonic extraction, lipid removal, purification by solid phase extraction cartridge, derivatization and detection by GC/MS. Optimizations were conducted for each pretreatment step above. After improvement, methyl tert-butyl ether (MTBE) was chosen as the extraction solvent, the lipid removal was conducted by repartition between organic solvent and alkaline solution. The best suitable pH condition is 2-2.5 for the inorganic solvent before used for further purification by HLB and silica column with the optimized elute solvent of acetone and mixtures of acetone and hexane (1:1), respectively. The recoveries of TBBPA and BPA spiked in maize samples were 69.26% and 66.47% with the relative standard deviation less than 5.26%, respectively, for the entire treatment procedure. Limits of detections were 4.10 ng/g and 0.13 ng/g for TBBPA and BPA in plant samples, respectively. In the hydroponic exposure experiment (100 µg/L, 15 d), the concentration of TBBPA in maize cultivated in pH 5.8 and pH 7.0 Hoagland solutions were 1.45 and 0.89 µg/g in roots, 8.45 and 6.34 ng/g in stems, while they were all below the detection limit for leaves, respectively. The distribution of TBBPA in different tissues was as the following order: root > > stem > leaf, illustrating the accumulated in the root and the translocation to stem. The uptake variations under different pH conditions were attributed to the change of TBBPA species, now that it shows greater hydrophobicity at lower pH condition as a kind of ionic organic contaminant. Monobromobisphenol A and dibromobisphenol A were identified as metabolisms products of TBBPA in maize. The efficiency and simplicity of the method that we proposed characterize its potential application as a screening tool for environmental monitoring and contribute to a comprehensive study of the environmental behavior of TBBPA.
Adiabatic propagation of beams in nonlocal nonlinear media with gradual loss and gain
Authors: Zheng Yuxin , Liang Guo , Guo Qi , Che Jiarui
Published: February 2023

We investigate the evolution of optical beam in the nonlocal nonlinear media with loss and gain using the variational approach and the numerical simulation. When the loss gradually changes to the gain, the optical beams can restore to their initial states, the phenomenon we called the "adiabatic propagation". We have proved that, as long as the changing rate of the loss and gain is small enough, the gain can exactly compensate the loss and the adiabatic propagation can occur for any beams with any profiles. However, the optical beams will shed a part of its energy as dispersive waves if they are lumped amplification like the cases of optical pulses in fibers. The numerical simulations agree well with the variational results.
Selection of electronically deficient products as very good antifungal condidates
Authors: Mihoubi Wafa , Elleuch Haitham , Boudabbous Manel , Ketata Emna , Borgi Ines , Rezgui Farhat , Gargouri Ali
Published: February 2023

In previous work, a new class of synthesized bioactive compounds of Morita-Baylis-Hillman adducts (MBH) showed an antioxidant and anti melanogensis activity [17–23]. Accordingly, in the present work the relationship between antifungal activity and the responsible chemical function of MBH adducts and their derivatives (alcohols, acetates, phosphonates and hydrazono phosphonates) was investigated against plant pathogenic fungi Aspergillus niger, Fusarium oxysporum, Penicillium occitanis, Trichoderma reesei, Stachybotrys microspora, Fusarium solani, Trichoderma parceramosum, fusarium aethiopicum, Alternaria alternata and Aspergillus flavus using the agar diffusion method. Results showed acetates displayed varying degrees of antifungal activity against several fungi tested, while just one alcohol compound showed lower activity. The derivative with five carbon (2g) was the most powerful with an inhibitor growth zone diameter of 4.75 ÷ 0.21, 6.1 ± 0.14, 4.35 ± 0.21, 3.9 ± 0.14, 4.54 ± 0.11, 3.55 ± 0.07, 3 ± 0, 3.2 ± 0.2, 5.36 ± 0.26 and 5.06 ± 0.5cm against; F. oxysporum, T. parceramosum, S. microspora, T. reesei, F. solani, P. occitanis, A. niger, F. aethiopicum, A. alternate and A. flavus respectively. Compared to the positive control the nystatin, most of the tested compounds exhibited moderate to strong inhibitory effects. The antifungal activity depended on the radical group. The novelty is that these adducts are evaluated for the first time for their antifungal effect. Antifungal activity is in general of linear or cyclic molecules coupled to six carbons. Here we show that the simple acetate six membered carbons are the most efficient molecule
Dialing out: A study on overcoming loneliness through call and touch
Authors: Gray Nicholas L.T. , Roberts S. Craig
Published: February 2023

As a social species, humans deprived of contact find loneliness a distressing and difficult condition. Recent research emphasises the influence of touch on alleviating loneliness. This research found touch reduces feelings of neglect, a subscale of loneliness. Affectionate touch, which demonstrates care or affection has been previously linked to wellbeing in couples. Here, we investigated whether the effect of simulated touch during a video conversation might be sufficient to influence feelings of loneliness. Sixty participants answered a survey about their home life and relationships, including items that assessed frequency of touch and feelings of loneliness. Following this, they participated in an online video call with three conditions: audio only, audio and video, or audio, video with ‘touch’ (a virtual ‘high-five’). Finally, immediately after the call, they completed a further brief survey including another measure of loneliness. We found that loneliness scores were reduced following the call, but there was no difference among conditions and no effect of a virtual touch However, we did find a significant association between the frequency of touch in a relationship and expression of loneliness, with individuals in low touch relationships having loneliness scores more comparable to single participants than to those in high touch relationships. Additionally, extraversion played a major role in moderating the effect of touch in relationships. These results emphasize the importance of physical contact in lowering feelings of loneliness within relationships, as well as the ability of calls to lower feelings of loneliness, regardless of whether they include video or ‘virtual touch’.
Platelets from patients with myeloproliferative neoplasms have increased numbers of mitochondria that are hypersensitive to depolarization by thrombin
Authors: Liang Hai Po Helena , Iqra Zeenet , Whittaker Shane , Tan Chuen Wen , Dale Brian J , Chen Vivien M , Ross David M
Published: February 2023

Thrombosis is one of the cardinal manifestations of myeloproliferative neoplasms (MPN). The mechanisms leading to a prothrombotic state in MPN are complex and remain poorly understood. Platelet mitochondria play a role in platelet activation, but their number and function have not been extensively explored in MPN to date. We observed an increased number of mitochondria in platelets from MPN patients compared with healthy donors. MPN patients had an increased proportion of dysfunctional platelet mitochondria. The fraction of platelets with depolarized mitochondria at rest was increased in essential thrombocythemia (ET) patients and the mitochondria were hypersensitive to depolarization following thrombin agonist stimulation. Live microscopy showed a stochastic process in which a higher proportion of individual ET platelets underwent mitochondrial depolarization and after a shorter agonist exposure compared to healthy donors. Depolarization was immediately followed by ballooning of the platelet membrane, which is a feature of procoagulant platelets. We also noted that the mitochondria of MPN patients were on average located nearer the platelet surface and we observed extrusion of mitochondria from the platelet surface as microparticles. These data implicate platelet mitochondria in a number of prothrombotic phenomena. Further studies are warranted to assess whether these findings correlate with clinical thrombotic events.
Optimization of aero-engine combustion chambers with the assistance of Hierarchical-Kriging surrogate model based on POD downscaling method
Authors: Tong Shuhong , Ma Yue , Guo Mingming , Tian Ye , Song Wenyan , Wang Heng , Le Jialing , Zhang Hua
Published: February 2023

In view of the long calculation cycle, high processing test and cost of the traditional aero-engine combustion chamber design process, which restricts the engine optimization design cycle, this paper innovatively proposes a surrogate model for the performance of aero-engine combustion chamber based on the POD-Hierarchical-Kriging method. Through experiments, the predicted results of the POD-Hierarchical-Kriging model are compared and analyzed with the calculated results of the one-dimensional program, and the root mean square error of the predicted values of combustion efficiency and total pressure loss are 0.0064% and 0.1995%, respectively. The accuracy of the POD-Hierarchical-Kriging model is compared with the cubic polynomials model, the basic Kriging model and the Hierarchical-Kriging model. It verifies the feasibility and accuracy of the POD-Hierarchical-Kriging model for the prediction of performance of aero-engine combustion chambers. The global sensitivity analysis method is applied to obtain the influence effect of the design variables on the performance. Then, a multi-objective optimization method based on NSGA-II algorithm is studied, and finally the optimal set of Pareto solutions is obtained and analyzed, which can be used to guide the optimal design of aero-engine combustion chamber and accelerate the progress of aero-engine development.
Metabolomics signatures of depression: the role of symptom profiles
Authors: milaneschi yuri , de Kluiver Hilde , Jansen Rick , Penninx Brenda , Giltay Erik , Schoevers Robert
Published: February 2023

Depression shows a metabolomic signature overlapping with that of cardiometabolic conditions. Whether this signature is linked to specific depression profiles remains undetermined. Previous research suggested that metabolic alterations cluster more consistently with depressive symptoms of the atypical spectrum related to energy alterations, such as hyperphagia, weight gain, hypersomnia, fatigue and leaden paralysis. We characterized the metabolomic signature of an “atypical/energy-related” symptom (AES) profile and evaluated its specificity and consistency. Fifty-one metabolites measured using the Nightingale platform in 2 876 participants from the Netherlands Study of Depression and Anxiety were analyzed. An ‘AES profile’ score was based on five items of the Inventory of Depressive Symptomatology (IDS) questionnaire. The AES profile was significantly associated with 31 metabolites including higher glycoprotein acetyls (b=0.13, p=1.35*10-12), isoleucine (b=0.13, p=1.45*10-10), very-low-density lipoproteins cholesterol (b=0.11, p=6.19*10-9) and saturated fatty acid levels (b=0.09, p=3.68*10-10), and lower high-density lipoproteins cholesterol (b=-0.07, p=1.14*10-4). The metabolites were not significantly associated with a summary score of all other IDS items not included in the AES profile. Twenty-five AES-metabolites associations were confirmed in replication analyses in data of 2 015 subjects collected at 6-year follow-up. We identified a specific metabolomic signature – commonly linked to cardiometabolic disorders – associated with a depression profile characterized by atypical, energy-related symptoms. The specific clustering of a metabolomic signature with a clinical profile may identify a more homogenous subgroup of depressed patients at higher cardiometabolic risk, and represent a valuable target for interventions aiming at reducing depression’s detrimental impact on health.
Subjective cognitive impairment in patients with cancer: A network approach
Authors: Baník Gabriel , Piterová Ivana , Adamkovič Matúš , Fedáková Denisa , Kentoš Michal , Bozogáňová Miroslava , Havrillová Dominika , Dědová Mária
Published: February 2023

Purpose:Cognitive impairment is a commonly reported side or late effect of cancer treatment deteriorating patients’ quality of life. As such, it is essential to look at patients’ self-evaluation in addition to objective assessments. The goals of the current study were to (1) examine the sociodemographic, clinical and psychological factors related to subjective cognitive impairment (SCI) perception; (2) analyze the complex mutual interconnections between SCIs; and (3) address patients’ perspectives on SCI and supportive care.
Method:A heterogeneous sample of oncological patients (N = 566; 68.6% female; M = 54, SD = 14.2, the most prevalent being breast cancer - 31.1%) was recruited.
Eighteen items covering the senses, attention, memory, spatial functions, decision-making and speech were administered. The response scale was constructed to reflect the chemotherapy-induced cognitive impairment (CICI) and post-traumatic growth (PTG) theories. A network of subjectively perceived changes in cognitive functions was estimated while three open-ended questions addressed patients’ perspectives on SCI.
Results:Within the network, deficits in spatial perception, attention focus and problem-solving ability were the highest on the strength index while the deficits related to the senses were the least influential. From the moderating factors, finishing chemotherapy, cancer relapse, pain, PTSD and sadness caused invariance in the network’s global strength or structure.
Conclusion:The findings indicate that psychological-based interventions focused on higher cognitive functions could improve patients’ quality of life. The presence of supportive care and available information could strengthen SCI intervention and prevention for patients with cancer.
Parameter Optimization of Plant-based Decellularized Scaffold for Biomedical Applications Using Response Surface Methodology
Authors: Mutra Jagadeesh Kumar Reddy , Jujjavarapu Satya Eswari , Patel Pushpendra , R Naga Giridhar Sree
Published: February 2023

The banana leaf scaffold is used for response surface optimization because it is a plant-based scaffold; we have various scaffolds to perform this experiment. In this experiment, CCD-RSM has been used as an experimental design to increase the concentration of detergent (SDS), the concentration of CaCl2, the size of the banana leaf, rpm, and no. of days. Twenty-one experimental runs were performed, and porosity and swelling ratios were optimized. The optimum conditions for this process were 0.25, 0.05% w/v SDS, and CaCl2 (50mM, 150mM, 250mM), RPM (120,180,240), size of banana leaf (0.5,2.5cm), and period were used as optimizing parameters and later on, we calculated the optimizing characters like porosity and swelling ratio of the scaffolds thus formed. With the help of all this, we optimized the swelling ratio and porosity. Finally, by using the design expert, we could derive various tables and graphs, like contour and 3D, to better understand the results.
Research on supply and demand matching model of transportation modes in MaaS system of integrated passenger transport hub based on deep learning
Authors: Liang Yun , Lan Chen , Dan Tu , Qiaoqiong Zeng , Yue Yang , Lin Chen
Published: February 2023

Advances in artificial intelligence and data acquisition technology are growing, the research on deep learning algorithm has gone deep into various fields. At this stage, the demand supply matching model under the comprehensive passenger transport hub travel system is obtained by analyzing the travel mode data. This paper takes traffic time as the research direction,uses machine learning and complex network theory to conduct in-depth learning algorithm research, respectively discusses, explores and forecasts the traffic supply and demand mode data, and explores the traffic mode supply and demand model under the comprehensive passenger transport hub travel service system. It is shown in traffic data that using the prediction form of deep learning to predict traffic conditions and travel pressure can enable traffic managers to master traffic dynamics and lead the direction for future traffic development. Finally, from the perspective of MaaS system, the paper uses big data and information processing methods to explore the supply and demand matching model in terms of transportation modes. The research shows that MaaS system can make overall planning in terms of traffic resources, provide reasonable travel modes for traffic travelers and match corresponding travel services. It not only makes overall planning and guarantee for travel services, but also promotes the sustainable development of the transportation supply and demand system.
Application of GIS Image System and Remote Sensing Technology in Physical Geography Land Planning
Authors: Xie Yun , Wang Zhiying , Fan Yi , Huang Jin , Xie Binggeng
Published: February 2023

Physical geography is the foundation of urban social and economic development. The quantity and quality of land resources and their distribution directly affect the economic, social, environmental and comprehensive benefits of the city. Now, in our country, low land use efficiency and irrational land structure in physical geography are both prominent phenomena. One of the main reasons is the lack of scientific and reasonable physical geography land use structure and utilization efficiency plan. Using remote sensing and geographic information system technology, this paper conducts a comprehensive and systematic survey of urban land use changes, and obtains land use classification maps for two periods, supports further research, and correctly guides people to develop and utilize natural resources and protect the ecological environment. Provide powerful reference materials for realizing sustainable land use and sustainable social and economic development. Based on the Landsat5TM image data in October 2018 and September 2020, this article is based on the land use remote sensing classification system of the Chinese Academy of Sciences "Chinese Resources and Environment Database" to classify the land use types in the survey area. In addition, this article will also introduce multi-source remote sensing image data fusion technology, including fusion information representation, fusion principle, fusion system framework model, fusion algorithm, control and application. By combining ETM remote sensing data with large-scale topographic maps, using non-remote sensing data and remote sensing data to investigate the status quo of land use and urban environment in physical geography, GIS is used as a supporting tool to construct a spatial database of urban environment, which promotes the development of research.
Bdnf-Nrf-2 crosstalk and emotional behavior are disrupted in a sex-dependent fashion in adolescent mice exposed to maternal stress or maternal obesity
Authors: Cirulli Francesca , Musillo Chiara , Kreutzberg Kerstin , Collacchi Barbara , Ajmone-Cat Maria Antonietta , De Simone Roberta , Lepre Marcello , Amrein Irmgard , Riva Marco , Berry Alessandra
Published: February 2023

Maternal obesity affects the developing fetal brain, leading to long-term negative outcomes comparable to those resulting from maternal psychological stress, although the mechanisms have not been completely elucidated. In this study we tested the hypothesis that prenatal adverse conditions as diverse as maternal stress and maternal obesity might affect emotional regulation and stress response in the offspring through common pathways, with a main focus on oxidative stress and neuroplasticity. We contrasted and compared adolescent male and female offspring in two mouse models of maternal psychophysical stress (restraint during pregnancy - PNS) and maternal obesity (high-fat diet before and during gestation - mHFD) by combining behavioral assays, evaluation of the hypothalamic-pituitary-adrenal (HPA) axis reactivity and gene expression analysis of selected neuroinflammatory and plasticity-related markers in the hippocampus as a key region involved in stress appraisal. Prenatal administration of the antioxidant N-acetyl-cysteine (NAC) was used as a strategy to protect fetal neurodevelopment from the negative effects of PNS and mHFD. Our findings show that these two stressors produce comparable effects, reducing brain anti-oxidant defenses (Nrf-2), leading to sex-dependent impairments of hippocampal Bdnf expression and alterations of the emotional behavior and HPA axis functionality. Prenatal NAC administration, by restoring the redox balance, was able to exert long-term protective effects on brain development, suggesting that the modulation of redox pathways might be an effective strategy to target common shared mechanisms between different adverse prenatal conditions.
Wearable-based Physical Activity as a Digital Biomarker of Inflammation, Biological Age, and Mortality: A Hierarchical Clustering Analysis of NHANES 2011-2014
Authors: Shim Jinjoo , Fleisch Elgar , Barata Filipe
Published: February 2023

Current measures of health and longevity are based on factors such as inflammation, biological age, and mortality. The potential of using continuously collected data from digital devices to explain these measures remains largely unstudied. In this work, we investigate a data-driven segmentation of the 24-hour physical activity profiles from wearables as a novel digital biomarker for longevity in 7,297 U.S. adults from the 2011–2014 National Health and Nutrition Examination Survey. Using hierarchical clustering, we identified five clusters and described them as follows: “High physical activity (PA)”, “Low PA”, “Mild circadian rhythm (CR) disruption”, “Extreme CR disruption”, and “Very low PA”. Young adults with extreme CR disturbance are seemingly healthy with few comorbid conditions, but in fact associated with higher white blood cell, neutrophils, and lymphocyte counts (0.05–0.07 log-unit, all p < 0.05) and accelerated biological aging (1.45 years, p < 0.001). Older adults with CR disruption are significantly associated with increased systemic inflammation indexes (0.09–0.13 log-unit, all p < 0.001), biological aging advance (1.31 years, p = 0.008), and all-cause mortality risk (HR = 1.67, p = 0.019). Our findings highlight the importance of circadian alignment on longevity across all ages and suggest that digitally measured physical activity data can help in identifying at-risk populations and personalize treatments for healthier aging.
Professionals' Quality of Life of dentist who works in public and private health care facilities
Authors: Noormohammadi Robab , Ghoflgari Tooba , Faghfouri Mehran , Maleki Azam
Published: February 2023

Background
Dentistry is a fascinating occupation but entails its own set of challenges. Long-term work and job stress can negatively impact dentists' physical and mental health, as well as their quality of life. The current study aimed to examine the professional quality of life of dentists who work in public and private healthcare facilities.
Methods
A cross-sectional study was conducted on 68 dentists. Data was collected using standard professional quality of life questionnaires and analyzed using descriptive statistics, independent t-tests, ANOVA, and a linear regression model.
Results
Participants' mean total professional quality of life score was 63.53, with a standard deviation of 18.29. As indicated by their scores, 27.9% (19 people) had a low level of professional quality of life, 20.6% (14 people) had an average level, and 51.5% (35 people) had a high level of professional quality of life. There was a significant relationship between income and type of organizational activity (P >0.05).
Discussion
Our result showed that more than half of dentists had a high level of professional quality of life. Considering the relationship between activity and income and the quality of life of public-sector dentists, it seems necessary to develop plans to improve the quality of their lives.
Data Monitoring in Student Psychological Automatic Evaluation System by using Dynamic Acquisition Algorithm
Authors: Li Peng
Published: February 2023

The purpose of Designing Embedded Internet of things and studying the ad hoc technology of gateway is to meet the monitoring requirements brought by the continuous expansion of data center. Among them, in the aspect of dynamic data monitoring, this paper designs a dynamic acquisition algorithm, that is, by analyzing the characteristics of data center resources and the number of information acquisition methods, so as to adjust the data acquisition cycle, so as to reduce the monitoring workload and improve the monitoring flexibility. At the same time, this paper also studies the automatic psychological evaluation system of students. It is found that with the intensification and efficient operation of social competition, some special groups of college students are facing increasing pressure, and events caused by psychological problems emerge one after another. Even though there are many psychological evaluation systems on the network. However, a large number of psychological knowledge and mental health management on the Internet can not effectively manage and improve the psychological status of college students. Therefore, the university needs to build a psychological evaluation system for college students in time, and combine the automatic psychological evaluation system for college students with embedded Internet of Things and cloud service technology to improve the accuracy of psychological evaluation. The application of the system, college students can independently evaluate their own mental state, if there are psychological problems can be timely counseling, not only can improve the level of mental health education in colleges and universities, but also can promote the development of physical and mental health.