bluuebunny/crossref_metadata_2025 huggingface dataset:
Human Decision-making Strategy Analysis during Large-scale Disaster
Authors: Zhang Zhiwen , Wang Hongjun , Fan Zipei , Song Xuan , Shibasaki Ryosuke
Published: November 2022

In recent decades, the frequency and intensity of natural disasters have increased significantly. Following these unexpected disasters, understanding and predicting human decision-making strategies during disasters will play a vital role in planning effective humanitarian relief, disaster management, and long-term societal reconstruction. However, such research is challenging due to the unavailability of reliable and large-scale human mobility data. In addition, these personal strategies during disasters become hard to predict due to the influences of multiple factors. In the decision-making process, what key (sometimes hidden) factors do people consider when making a particular mobility decision following a large-scale disaster? In this study, we construct a large human mobility database collected from mobile devices (GPS records of 66,598 users in the Greater Tokyo area), and analyze the human decision-making strategies following Japan’s 2011 Tohoku earthquake. Except for users’ location-based information, we also extract the grid-based stay areas from historical check-ins (normal days before disasters) and discover the functions of those areas combined with points of interest (POI) located in an area. In the final, we jointly model the users’ location-based factors and historical check-ins information, and develop an empirical prediction for decision-making strategies (i.e., destination, travel mode, and departure time from their workplaces) following the Tohoku earthquake. An explainable analysis is conducted to explore the fundamental laws that govern human mobility following disasters. The results are encouraging to support future interventions in analyzing decision-making strategies during disasters, and understanding the relationship between decision making and considered multiple factors/features (as well as the relationship between feature values and possible predicted values).
Immune response to pertussis vaccine in COPD patients
Authors: Feredj E. , Wiedemann A. , Krief C. , Maitre B. , Derumeaux G. , Chouaid C. , Corvoisier P. Le , Lacabaratz C. , Gallien S. , Lelièvre JD , Boyer L.
Published: November 2022

Exacerbation triggered by respiratory infection is an important cause of morbidity and mortality in Chronic Obstructive Pulmonary Disease (COPD) patients. Strategies aiming to preventing infection may have significant public health impact. Our previous study demonstrated decreased immunological response to seasonal flu vaccination in COPD patients, questioning the efficiency of other vaccines in this group of patients. We performed a prospective, monocenter, longitudinal study that evaluated the humoral and cellular responses upon pertussis vaccination. We included 13 patients with stable COPD and 8 healthy volunteers. No difference in circulating B and T cell subsets at baseline was noted. Both groups presented similar levels of TFH, plasmablasts and pertussis specific antibodies induction after vaccination. Moreover, monitoring T cell immunity after ex-vivo peptide stimulation revealed equivalent induction of functional and specific CD4 + T cells (IFNg, TNFa and IL-2-expressing T cells) in both groups. Our results highlight the immunological efficiency of pertussis vaccination in this particularly vulnerable population and challenge the concept that COPD patients are less responsive to all immunization strategies. Healthcare providers should stress the necessity of decennial Tdap booster vaccination in COPD patients.
Temporal evolution of mechanical stimuli from vascular remodeling in response to the severity and duration of aortic coarctation
Authors: Azarnoosh Jamasp , Ghorbannia Arash , Ibrahim El-Sayed H. , Jurkiewicz Hilda , Kalvin Lindsey , LaDisa John F.
Published: November 2022

Coarctation of the aorta (CoA) is one of the most common congenital cardiovascular diseases. CoA patients frequently undergo surgical repair, but hypertension (HTN) is still common. The current treatment guideline has revealed irreversible changes in structure and function, yet revised severity guidelines have not been proposed. Our objective was to quantify temporal alterations in mechanical stimuli and changes in arterial geometry in response to the range of CoA severities and durations seen clinically. Rabbits were exposed to CoA resulting in BPGpp severities of ≤ 10, 10–20, and ≥ 20 mmHg for a duration of ~ 1, 3, or 20 weeks using permanent, dissolvable, and rapidly dissolvable sutures. Elastic moduli and thickness were estimated from imaging and longitudinal fluid-structure interaction (FSI) simulations were conducted at different ages using geometries and boundary conditions measured empirically. Mechanical stimuli were characterized including blood flow velocity patterns, wall tension, and radial strain. Empirical results show vascular alternations including thickening and stiffening proximal to the coarctation with increasing severity and/or duration of CoA. FSI simulations indicate wall tension in the proximal region increases markedly with coarctation severity. Importantly, even mild CoA induced stimuli for remodeling that exceeds values seen in adulthood if not treated early and using a BPGpp lower than the current clinical threshold. The findings are aligned with observations from other species and provide some guidance for the values of mechanical stimuli that could be used to predict the likelihood of HTN in human patients with CoA.
Investigating mechanisms of laser pulse-induced reflectivity modulations in photoacoustic remote sensing with a 10 million frames-per-second camera
Authors: Haven Nathaniel Jeremy Meyer , Martell Matthew T. , Li Hoayang , Hogan James D. , Zemp Roger J.
Published: November 2022

Photoacoustic remote sensing has been recently developed as an all-optical imaging modality capable of imaging a variety of endogenous contrast agents label-free. Initially predicted laser pulse-induced refractive index perturbation-based interrogation beam reflectivity modulations have been found to be orders of magnitude smaller than those typically observed experimentally. In this report we utilize a 10 million frames-per-second camera to further investigate these predicted reflectivity modulations, while also exploring other potential mechanisms of laser pulse-induced reflectivity modulations. Laser-induced motion is demonstrated both laterally for gold wires suspended and submerged in air and water, respectively, and carbon fibers submerged in water, and axial motion is observed in gold wires submerged in a depth gradient of intralipid solution. This laser-induced sample motion is anticipated to cause reflectivity modulations local to the interrogation beam profile in microscopy set-ups. Non-motion-based maximum intensity modulations of 3% are also observed in gold wires submerged in water, indicating the presence of the originally predicted reflectivity modulations. Overall, these observations are important as they provide a widefield view of laser-pulse interactions unavailable in previous point scanning-based photoacoustic remote sensing microscopy configurations, where observed mechanisms occur on time-scales orders of magnitude faster than equivalent field of view point scanning capabilities.
Trans-resveratrol-3-o-b-glucoside, an alternative therapy for Alzheimer's disease, an in-silico approach
Authors: Bhattacharya Arka , Singh Rajveer
Published: November 2022

In neurology, Alzheimer's disease (AD) requires the greatest unmet medical need. While current medications reduce symptoms, they have only minor disease-modifying effects. However, several methods designed to stop the progression of the disease have moved to clinical trials in recent years. The most sophisticated of these focus on amyloid- β peptide formation and clearance, which is a hallmark of Alzheimer's and is suspected to play a role in disease development. Therapies that target metabolic dysfunction and aberrant tau filament aggregation, another crucial aspect of the disease, are also being tested in the clinic. Glycogen synthase kinase 3 beta (GSK3β) has been identified as a promising target for treating AD, where abnormal activation of this enzyme has been associated with hyperphosphorylation of TAU proteins. This current study aims to meet the imperative necessity of effective AD therapy with a computational multi-target drug repurposing approach. This study focused on screening the Resveratrol derivative trans-Resveratrol-3-O-b-glucoside as a GSK3β blocker. trans-Resveratrol-3-O-b-glucoside showed good binding affinity towards the biomolecular markers of AD, such as GSK3β, tau, Acetylcholinesterase, and proinflammatory mediators such as NF-κβ and COX2. Further trans-Resveratrol-3-O-b-glucoside analyzed by molecular simulation revealed that it binds tightly to the active site of GSK3β. This study suggests that trans-Resveratrol-3-O-b-glucoside can be a potential agent for treating AD.
Adsorption of BEZAKTIV BLAU V3-R and BEZAKTIV BLAU S-2R reactive dyes onto rice husk modified by the circular economy concept
Authors: Mladenovic Nina , Petkovska Jovana , Dimova Vesna , Dimitrovski Dejan , Jordanov Igor
Published: November 2022

Rice husk, modified with effluent from the alkaline scouring of cotton, employing an inexpensive treatment based on the circular economy concept, is used as a bio-sorbent to study the equilibrium and kinetic on cold brand BEZAKTIV BLAU V3-R (BBV3-R) and medium brand BEZAKTIV BLAU S-2R (BBS2-R) reactive dyes. 10, 20, and 40 g L-1 rice husk is used to follow adsorption of 0.1, 0.2, 0.3, 0.4, and 0.5 g L-1 BBV3-R and BBS2-R in a presence of 60 g L-1 NaCl at pH 10, at the temperature of 25oC and 40oC, respectively. Langmuir, Freundlich, and Dubinin-Radushkevic's adsorption models were employed, with the Freundlich model proving the best fit for our data. Activation energy calculated with the Dubinin-Radushkevic model (lower than 8 KJ mol-1) confirms the physical sorption of these reactive dyes onto the husk. The obtained maximum experimental absorption capacities of 122.2 mg g-1 for BBV3-R and 171.7 mg g-1 for BBS2-R using 10 g L-1 ERH are the best found in the literature. Pseudo-second-order model determines the adsorption kinetics, while the liquid film diffusion model is rate-determining. This paper demonstrates the applicability of the circular economy concept to obtain an efficient adsorbent for purifying colored effluent enriched with reactive dyes, which are one of the most challenging dyes in the textile industry from the aspect of their effluent purifying.
Machine Learning Assisted Optimization of Dielectric Resonator based mm-Wave MIMO Antenna for 5G Communication Systems
Authors: . Sumit , Kumar Vinay , Pandey Ashish , Sharma Anand , Ranjan Pinku , Tripathi Rajeev
Published: November 2022

In this paper, a dual-port dielectric resonator (DR) multiple-input multiple-output (MIMO) antenna along with a suspended metasurface is designed and analyzed. The metasurface is used to improve the isolation value between the port of the proposed antenna. Moreover, different machine learning (ML) algorithms (Decision Tree, Deep Neural Network, K-nearest Neighbor, Random Forest, and Extreme Gradient Boosting) are utilized for optimization purposes. The performance of different ML algorithms are compared in term of measured parameters. The prototype of the proposed antenna design is fabricated for verification purposes. The measured result confirms that the proposed antenna operates from 26.24 to 27.94 GHz, with an isolation level of more than 45 dB between the ports. The gain of the proposed antenna is around 5.0 dBi in the operating band. Due to all these features, the proposed antenna can be efficiently utilized for a 5G communication system.
Development of a novel NGS methodology for ultrasensitive circulating tumour DNA detection as a tool for early-stage breast cancer diagnosis
Authors: Jiménez-Rodríguez Begoña , Alba-Bernal Alfonso , López-López Esperanza , Quirós-Ortega María Elena , Carbajosa Guillermo , Garrido-Aranda Alicia , Álvarez Martina , Queipo-Ortuño María Isabel , Vicioso Luis , Díaz-Córdoba Gema , Roldán-Díaz María Dunia , Velasco-Suelto Jesús , Hernando Cristina , Bermejo Begoña , Julve-Parreño Ana , LLuch Ana , Pascual Javier , Comino-Méndez Iñaki , Alba Emilio
Published: November 2022

BACKGROUND
Breast cancer (BC) is the most prevalent cancer in women. While usually detected when localized, invasive procedures are still required for diagnosis.
METHODS
Herein, we developed a novel ultrasensitive pipeline to detect circulating tumour DNA (ctDNA) in a series of 75 plasma samples from localized BC patients prior to any medical intervention. We first performed a tumour-informed analysis to correlate the mutations found in tumour tissue and plasma. Disregarding the tumour data next, we developed an approach to detect tumour mutations in plasma.
RESULTS
We observed a mutation concordance between tumour and plasma of 29.50% with a sensitivity down to 0.03% in mutant allele frequency (AF). We detected mutations in 33.78% of the samples, identifying 8 patients with plasma-only mutations. Altogether, we determined a specificity of 86.36% and a positive predictive value of 88.46% for BC detection. We demonstrated an association between higher ctDNA median AF and higher tumour grade, multiple plasma mutations with likelihood of relapse and more frequent TP53 plasma mutations in hormone receptor-negative tumours.
CONCLUSIONS
Overall, we have developed a unique ultra-sensitive sequencing workflow with a technology not previously employed in early BC, paving the way for its application in BC screening.
Entomological drivers of uneven malaria transmission in urban lowland areas in Bouaké, Côte d’Ivoire
Authors: Dahoui Milossé MC , Adou Kouassi A , Coulibaly Baba , Niamien Koffi L , Koné Aboubacar , Cornelie Sylvie , Zoh Dounin D. , Assouho Konan F. , Moiroux Nicolas , Adja Akré M , Fournet Florence
Published: November 2022

Background
The use of urban lowlands for agriculture contributes to the food security of city- dwellers, but promotes malaria transmission. The objective of our study was to characterize the entomological drivers of malaria transmission in two lowlands (N’Gattakro and Odiennekourani) in the city of Bouaké, Côte d’Ivoire.
Methods
The human landing catch technique was used to capture mosquitoes in houses located at the edge of two lowlands in Bouaké from February to December 2019. A drone was used to monthly describe the different crops (rice and vegetables) at the parcel level. The different mosquito species were identified morphologically and by PCR analysis for the Anopheles gambiae complex. Anopheles infection by Plasmodium parasites was assessed by quantitative PCR. Mosquito diversity, biting behaviour and rhythm, and malaria transmission were determined in each lowland and compared.
Results
Anopheles gambiae s.l. was predominant in N’Gattakro and Culex quinquefasciatus in Odiennekourani. Four Anopheles species were identified: An. gambiae s.l. and Anopheles funestus in both lowlands, Anopheles pharoensis in N'Gattakro, and Anopheles ziemanni in Odiennekourani. Within the An. gambiae complex, three species were caught: An. gambiae s.s., Anopheles coluzzii, and Anopheles arabiensis for the first time in Côte d'Ivoire (30.1%, 69.9% and 0% in N’Gattakro, and 45.1%, 52.6% and 2.4% in Odiennekourani, respectively). An. gambiae s.l. species exhibited a significant exophagic behaviour in N’Gattakro (77.1% of outdoor bites versus 52.2% in Odiennekourani). In N’Gattakro, 12.6% of captures occurred before bedtime and after waking up, 15.1% in Odiennekourani. The mean human biting rate was higher in N’Gattakro than in Odiennekourani (61.6 versus 15.5 bites per person per night). Overall, Anopheles infection rate was 0.68%, with 0.539 and 0.029 infected bites per person per night in N’Gattakro and Odiennekourani, respectively.
Conclusion
The risk of malaria in urban agricultural lowland areas is uneven. The role of agricultural developments and irrigation patterns in the production of larval habitat should be explored. The exophagic behaviour of Anopheles vectors raises the question of the residual transmission that needs to be assessed to implement appropriate control strategies.
Hemorrhage induced by Thrombolysis: new insights from a real-world pharmacovigilance study
Authors: Guo Kangyuan , Zhang Li , Feng Zhanchun , Xia Xudong , Sun Xiaobo , Yan Ziqi , Jiao Zhiming , Feng Da
Published: November 2022

Background: Hemorrhage represents the most common and serious side effect of thrombolytic therapy. Many studies have compared the risk of bleeding between different thrombolytic therapy, but analysis of time-to-onset for hemorrhage induced by thrombolysis is yet sparse.
Methods: We conducted a retrospective study based on the adverse drug reaction reports on antithrombotic agents collected by the Henan Adverse Drug Reaction Monitoring Center. We assessed the reporting odds ratio to determine the disproportionate reporting signals for bleeding and the Weibull shape parameter was used to evaluate the time-to-onset data.
Results: In the signal detection, crude low molecular weight heparin-hemorrhage was found as a positive signal. The hemorrhage for most antithrombotic agents was random failure profiles. In particular, the hazard of hemorrhage decreased over time for warfarin and clopidogrel and increased for alteplase, nadroparin, and dipyridamole.
Conclusions: We found that the patients taking Crude low molecular weight heparins were more likely to bear hemorrhagic side effects, which may be attributed to the severely irrational use of this medication under improper management. The risk of bleeding decreased over time for warfarin and clopidogrel and increased for alteplase, nadroparin, and dipyridamole.
A Comparison study of different grasses on agronomic performance and chemical composition across three altitudes and harvesting dates in Ethiopia
Authors: Adnew Wubetie
Published: November 2022

One of the major limiting factors of livestock production in Ethiopia is the very low quantity and quality of livestock feeds supplied in the country. This calls for seeking forages that complement poor quality feeds in the country. Hence, this research project was accomplished to comparatively evaluate and find compatible forages among three types of grass. The target of this paper was to compare three types of grass agronomic performance and chemical composition under three different agro-ecologies and three harvesting dates (60, 90, and 120 days). Field experiments were carried out in Tach Gayint (low altitude), Fogera (mid-altitude, and Debre Tabor (high altitude) Districts in 2017/2018. The treatments were laid out in a factorial RCBD (randomized complete block design) with three replications. The treatments contain combinations of 3 altitudes and 3 harvesting dates. Agronomic, yield, and chemical composition data were collected from all treatments in all locations. The collected data were subjected to analysis of variance procedures with a P 0.05 significance test. Altitudes and harvesting dates showed significant effects on the agronomical performance and chemical composition of those 3 types of grass The highest plant height (PH) and dry matter yield (DMY) by Napier and the number of tillers per plant (NTPP) by Mulato II were recorded at all altitudes. Similarly, harvesting dates showed a significant difference (P 0.05) in DMY and CP for all grasses in all studied areas. The significant difference in DMY was increasing as the harvesting date increased, but CP was contrariwise. Although all Napier grass recorded the highest biomass yield in all studied areas and showed high potential as an alternative livestock feed in Ethiopia, the highest crude protein value and the least value of NDF and ADF (best forage quality parameters) were recorded by Mulato II. Thus, the results of this study revealed that Brachiaria hybrid cv. Mulato II has great potential to fulfil the demands for quality feeds for livestock production, especially at low altitudes However, the current result alone might not lead to a final valid conclusion, hence it is recommended to follow up with a further study about feed value experimental using suitable animals.
Tumor immunophenotyping-derived signature identifies prognosis and neoadjuvant immunotherapeutic responsiveness in gastric cancer
Authors: Wang Jia-Bin , Qiu Qing-Zhu , Zheng Qiao-Ling , Zhao Ya-Jun , Xu Yu , Zhang Tao , Wang Shuan-Hu , Wang Quan , Jin Qin-Wen , Ye Yin-Hua , Li Ping , Xie Jian-Wei , Lin Jian-Xian , Lu Jun , Chen Qi-Yue , Cao Long-Long , Yang Ying-Hong , Zheng Chao-Hui , Huang Chang-Ming
Published: November 2022

Background
The effectiveness of neoadjuvant immune checkpoint inhibition (ICI) therapy has been confirmed by clinical trials; however, patients that are suitable for receiving this therapy remain unspecified. Previous studies have demonstrated that the tumor microenvironment (TME) dominates immunotherapy; therefore, an effective classification strategy for the TME is needed.
Methods
Five publicly available datasets (n = 1,426) were used to identify the immunophenotypic features of the TME and to screen for core molecules. The training cohort (n = 506) was used to construct the immunophenotypic score (IPS) and six independent external centers (n = 638) were recruited as validation. Besides, 52 patients with GC receiving neoadjuvant anti-PD-1 therapy was enrolled to explore the value of the IPS in neoadjuvant ICI therapy. Moreover, the IPS-specific TME was profiled by multiplexed immunohistochemical staining and immunohistochemical staining.
Results
Five immunophenotype-related features (WARS, UBE2L6, GZMB, BATF2, and LAG-3) associated with prognosis and the immunotherapeutic response in GC were identified, forming the IPS. The data from seven medical centers (n = 1,144) indicated that the IPS is a robust and independent biomarker for GC and superior to the traditional TNM stage. Furthermore, IPSLow was defined as the immune-activated tumor that benefited from neoadjuvant anti-PD-1 therapy, while IPSHigh exhibited more immune unresponsive signals. Notably, patients with IPSLow and PD-L1 (CPS) ≥ 5 were observed to be the most favorable group for neoadjuvant anti-PD-1 treatment.
Conclusions
The IPS could serve as a valid quantitative tool for immunophenotyping to improve clinical outcomes, and it provides an effective reference for the implementation of neoadjuvant ICI therapy for patients with GC.
Extreme weather events and its impacts on rice production in coastal Odisha region of India
Authors: Vijayakumar S , Nayak A. K. , Manikandan N. , Pattanaik Suchismita , Tripathi Rahul , Swain Chinmaya Kumar
Published: November 2022

The study investigates trend in extreme daily precipitation and temperature over coastal Odisha, India. 18 weather indices (8 related to temperature and 10 related to rainfall) were calculated using RClimDex software package for the period 1980–2010. Trend analysis was carried out using linear regression and non-parametric Mann-Kendall test to find out the statistical significance of various indices. Results indicated, a strong and significant trend in temperature indices while the weak and non-significant trend in precipitation indices. The positive trend in Tmax mean, Tmin mean, TN90p (warm nights), TX90p (warm days), diurnal temperature range (DTR), warm spell duration indicator (WSDI), consecutive dry days (CDD) indicates increasing the frequency of warming events in coastal Odisha. Similarly, positive trend in highest maximum 1-day precipitation (RX1), highest maximum 2 consecutive day precipitation (RX2), highest maximum 3 consecutive day precipitation (RX3), highest maximum 5 consecutive day precipitation (RX5), number of heavy precipitation days (≥ 64.5mm), number of very heavy precipitation days (≥ 124.5mm) and negative trend in the number of rainy days (R2.5mm), consecutive wet days (CWD) indicate changes toward the more intense and poor distribution of precipitation in coastal Odisha. The combined effect of precipitation and temperature extreme events showed negative effects on rice grain yield. With the increasing number of extreme events there was sharp decline in rice grain yield was observed in the same year in all the coastal districts. This study emphasizes the need for new technology/management practice to minimize the impacts of extreme weather events on rice yield.
Determinant of earnings response coefficient on the Indonesian and Singaporean stock exchanges during the COVID-19 pandemic
Authors: Baroroh Niswah , Yanto Heri , Khafid Muhammad , Waluyo Jati Kuat , Ayu Setyowati Dinda
Published: November 2022

Earnings response coefficient (ERC) is one of the important things for companies and investors, as it reflects a company’s good value. The COVID-19 pandemic, which is happening globally, has greatly affected capital market conditions and companies in general. It is necessary to examine what factors affect ERC significantly to provide an overview to the company while maintaining the good name of the company. This study aims to analyze the effect of firm growth, leverage, information asymmetry, and systematic risk on ERC with dividend payout ratios as moderating on the Indonesia Stock Exchange and Singapore Stock Exchange. The study uses a quantitative approach with secondary data in the form of companies’ annual reports. Population was made up of food and beverage and tobacco manufacturing companies in 2018–2020. It consists of 38 JASICA index companies on IDX, and 33 SGX index companies on SGX. The results showed that, firstly, leverage and systematic risk had a significant negative effect on ERC. Second, firm growth and information asymmetry have no effect on ERC. Third, dividend payout ratio can weaken a positive influence of information asymmetry on ERC. Fourth, dividend payout ratio failed to moderate a positive effect of firm growth and a negative effect of leverage and systematic risk on ERC. All variables have no significant statistical difference between the two stock exchanges. These results indicate that a company must improve the performance and quality of information; pay attention to obligations, mitigate and manage risk to obtain optimal ERC.
Effect of Camellia sinensis Origin and Heat Treatment in the Iron Oxides Nanomaterials Composition and Fenton Degradation of Methyl Orange
Authors: Franco Raissa , Silva Ana Luisa , Licea Yordy , Alzamora Mariella , Sánchez Dalber , Carvalho Nakédia
Published: November 2022

Sustainable and environmentally friendly methods for nanomaterials synthesis have been emerging recently. The use of extracts of polyphenol-rich plants with high reducing and chelating power is advantageous because the polyphenol can protect the nanomaterial from agglomeration and deactivation. Green nanomaterials have been applied in several areas, including remediation of toxic organic pollutants from contaminated effluents. Herein, we describe the preparation of green iron oxide nanoparticles (IONPs) with extracts of the plant Camellia sinensis as black tea for dye removal application. The as-prepared IONPs were composed of amorphous FeOOH and FeII/III-polyphenol complexes. To obtain crystalline and pure iron-based nanomaterials, the amorphous precursor was annealed at 900 ºC. Samples of black tea from different regions were used to verify the reproducibility of the iron phases formed. The same iron phases were obtained for all black tea samples, α-Fe2O3 (hematite), FePO4, and Fe3PO7, but in different proportions. The materials were applied as heterogeneous-Fenton catalysts for the removal of the dye methyl orange. The amorphous as-prepared IONPs were more active than the respective annealed IONPs due to the proton release from the polyphenol into the reaction medium, setting the pH to around 3, which is the optimum pH for the Fenton system.
Atuação profissional do cirurgião-dentista diante da Lei Maria da Penha
Authors: Rhonan Ferreira da SILVA  , Mauro Machado do PRADO  , Robson Rodrigues GARCIA  , Eduardo DARUGE JÚNIOR  , Eduardo DARUGE
Published: November 2022

Introdução: No Brasil, a violência contra a mulher constitui um problema social que está sendo tratado em diversos programas de saúde pública, pois a prática atinge todas as classes sociais. Nesse sentido, e com base no princípio de que a mulher é considerada a parte vulnerável numa relação familiar, foi aprovada a Lei n.º 11.340/2006, conhecida como Lei Maria da Penha, que aumenta o rigor das punições contra aqueles que agridem as mulheres do seu círculo familiar. Entre os diversos tipos de agressão que a mulher pode sofrer, as de natureza física são as que podem ser mais facilmente identificadas pelos profissionais da área de saúde, inclusive pelo cirurgião-dentista. Objetivo e relato de caso: Este estudo visa relatar dois casos de violência contra a mulher em que houve envolvimento de lesões na área de cabeça e pescoço. No primeiro caso, a vítima foi agredida com um soco e perdeu dois dentes anteriores (lesão grave); no segundo, a vítima também foi agredida com socos que produziram equimoses orbitárias e periorais (lesão leve), tendo estas regredido após 30 dias. Conclusão: É grande a importância ético-legal do registro adequado dos procedimentos efetuados em vítimas de agressão, pois essa documentação odontológica pode ser solicitada para subsidiar tanto uma avaliação odontolegal como um processo judicial movido contra o agressor.
Fibrous dysplasia of the maxillary sinus: case report
Authors: Vijayalakshmi Subramaniam  , Adarsha Tuluvinakoppa Vasudeva Herle
Published: November 2022

Introduction and objective: Fibrous dysplasia is a non-neoplastic lesion of unknown origin with one-fourth involving head and neck. The aim of this paper is to report a case of fibrous dysplasia of the maxillary sinus, describing its clinical presentation, radiological features, histopathological appearance and surgical management. Case report: 38-year-old female patient who presented with a history of fullness of the right cheek and intraoral swelling was diagnosed to have fibrous dysplasia of the maxilla with involvement of the maxillary sinus based on the radiological features. The case was managed surgically via a conventional Caldwell-Luc approach. The histopathology of the excised tissue confirmed the diagnosis of fibrous dysplasia. Conclusion:Fibrous dysplasia is a benign non-neoplastic lesion of unknown origin that rarely involves the maxillary sinus. This case report highlights the clinical, radiological and pathological features of fibrous dysplasia and its surgical management. Conventional Caldwell-Luc approach allows more exposure and ensures complete removal of the lesion.
Towards Safe Patient Identification Practices: the Development of a Conceptual Framework from the Findings of a Ph.D. Project
Authors: De Rezende Helena , Melleiro Marta Maria
Published: November 2022

Patient identification errors are considered the root cause of other patient safety incidents. Despite the development, recommendation, and application of several initiatives to reduce and prevent misidentification in hospital settings, errors continue to occur. They directly impact the quality of care provided, resulting in delays in care, added costs, unnecessary injuries, misdiagnosis or wrong treatment, and other serious and irreversible types of harm and death. Furthermore, the certainty of the evidence of the effectiveness of interventions to reduce patient identification errors is considered very low.

This paper reports on the development of a conceptual framework for safe practices in the area of patient identification. The proposed conceptual framework was developed based on presuppositions regarding learning health systems and the available evidence from the published systematic reviews of the effectiveness of interventions in reducing patient identification errors in hospital settings. The core circle of the framework represents the partnership between managers, healthcare professionals, patients, and families working toward integrative and collaborative efforts for safe patient identification practices. The inner dimension states the recommendations for practice sustained by applying technological resources and educational strategies to raise awareness of the importance of accurate patient identification and interdisciplinarity, which works as an axis that supports integrated and collective work between healthcare professionals aiming for safe care. The outer dimension represents recommendations for teaching and research to develop effective patient identification practices that can enhance patient safety and the quality of care provided in hospital settings.

This framework provides a valuable method for engaging interdisciplinary teams to improve the safety of patient identification systems.
Principles of Forming a Strategy for Reducing the Psychological Tension of Social Network Users
Authors: Khakimova Aida , Zolotarev Oleg , Zatsman Igor
Published: November 2022

Aims:

The purpose of the study was to develop principles of a strategy for influencing the psychological state of social network users using the example of the Russian-language segment of Twitter, one of the reasons for which is the lack of awareness about aspects of the coronavirus infection.

Background:

In contrast to the existing works on mood management and Emotion Regulation Strategies, there are principles based not on emotional regulation (cognitive reappraisal and expressive suppression), but on information processing of the content of social media messages and forums.

Objective:

The objective of the study was to develop principles of a strategy for reducing the psychological tension of social network users (further – Strategy) based on the Russian-language segment of Twitter.

Methods:

The proposed research methodology includes a study of the discussion field in the active forum of the Runet (the qualitative aspect of emotionality as a reflection of psychological tension) and the Russian-language segment of Twitter (the quantitative aspect of terminology frequency). The qualitative research consisted in isolating the sensitive words used by vaccine opponents to describe their beliefs. A multi-stage methodology has been developed for the meaningful analysis of Twitter users’ messages.

Results:

. The result of the study is a methodology for developing principles of the Strategy. Based on this methodology, the following aspects of the problem have been developed: 1) the principle of clarifying the definition of psychological tension; 2) the principle of comparing the user and scientific meanings of terms, taking into account the contexts of their use; 3) the principle of contextual comparison of the user’s and scientific meanings of the term; 4) the principle of visual popularization of scientific knowledge.

Conclusion:

An original methodology was created for developing principles of the Strategy. In contrast to the existing works on mood management and Emotion Regulation Strategies, there are principles based not on emotional regulation (cognitive reappraisal and expressive suppression [1]), but on information processing of the content of social media messages and forums.

Other:

A new approach to reducing the psychological tension of social media users can contribute to sharing timely, accurate and positive information about COVID-19, and reduce excessive discussions about COVID-19, which can positively affect the psychological well-being of the general public.
Evaluation of the Implementation Integrated Biological System Industrial Wastewater Treatment Plant: Pollutant Removal, Operational Maintenance, Estimation of Carbon Emission
Authors: Setianingsih Nanik Indah , Farida Crisnaningtyas  , Agus Purwanto  , Ikha Rasti Julia Sari
Published: November 2022

The development of WWTP in business activities needs to pay attention to getting appropriate WWTP that is more valuable to support sustainable development. This study aims to evaluate two systems of integrated biological WWTP; anaerobic-wetland, and anaerobic-aerobic-wetland, including the effectiveness of pollutant removal, operational and maintenance, and estimation of carbon emissions. The performance of pollutant removal was evaluated by analyzing inlet and outlet samples of WWTP. An operational and maintenance evaluation was carried out by studying the WWTP operating system and maintenance procedures supported by a literature review. Carbon emission estimation was carried out using a formula referring to the IPCC Guidelines (2006). Organic matter removal of anaerobic-aerobic-wetland WWTP in the form of BOD₅ and COD are 92.12% and 91.72%, respectively, higher than anaerobic-wetland WWTP are 88.69% of BOD₅ and 77.62% of COD. Anaerobic-aerobic-wetland WWTP needs more maintenance and operation than anaerobic-wetland WWTP. The highest carbon emission of both WWTP is 41530.91 kgCO₂ eq/year of anaerobic-wetland WWTP from the organic matter removal process and 46485.15 kgCO₂ eq/year of anaerobic-aerobic-wetland WWTP. Electrical energy consumption emits in anaerobic-aerobic-wetland WWTP is 22338 kgCO₂ eq/year higher than anaerobic-wetland WWTP at 4299.70 kgCO₂ eq/year. Total carbon emissions of anaerobic-wetland WWTP is 47404.58 kgCO₂ eq/year and anaerobic-aerobic-wetland WWTP is 68900.23 kgCO₂ eq/year.
The Kinetic Analysis and Adsorption Isotherm of Chicken Egg Shells and Membranes Against Synthetic Dyes
Authors: Hevira Linda , Gampito
Published: November 2022

Textile industry waste at this time is enough to worry the community and the environment. The presence of synthetic dyes in water is hazardous, even in small concentrations. These synthetic dyes are derivatives of aromatic compounds such as benzene, toluene, and naphthalene, which are more resistant and stable than natural dyes. The adsorption method is used because it is easier to do, has no side effects, and does not require complicated and expensive equipment. In this study, the shells and membranes of discarded chicken eggs became useful as an absorbent of indigo carmine dye with an adsorption capacity of 6.399 mg/g. The adsorption reaction kinetics were analyzed from the optimal contact time data, and the reaction isotherm was analyzed from the adsorption optimal concentration data. The kinetic model that fits the research is the second pseudo-order with R2 = 0.9998. The adsorption mechanism demonstrates that the adsorption capacity is proportional to the adsorbent's active sites. The adsorption isotherm model, with R2 = 0.9748, is more closely related to the Freundlich isotherm model, indicating that adsorption occurs in several layers. From an economic point of view, chicken egg shells and membranes can be recommended as dye absorbers that are eco-friendly, efficient, and simple to obtain while lowering organic solid waste.
Formatting requirements for papers
Authors: Editorial Article
Published: November 2022

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Practical Considerations for Developing Clinical Natural Language Processing Systems for Population Health Management and Measurement
Authors: Tamang Suzanne , Humbert-Droz Marie , Gianfrancesco Milena , Izadi Zara , Schmajuk Gabriela , Yazdany Jinoos
Published: November 2022

Experts have noted a concerning gap between clinical natural language processing (NLP) research and real-world applications, such as clinical decision support. To help address this gap, in this viewpoint, we enumerate a set of practical considerations for developing an NLP system to support real-world clinical needs and improve health outcomes. They include determining (1) the readiness of the data and compute resources for NLP, (2) the organizational incentives to use and maintain the NLP systems, and (3) the feasibility of implementation and continued monitoring. These considerations are intended to benefit the design of future clinical NLP projects and can be applied across a variety of settings, including large health systems or smaller clinical practices that have adopted electronic medical records in the United States and globally.
Characterizing the Gaps Between Best-Practice Implementation Strategies and Real-world Implementation: Qualitative Study Among Family Physicians Who Engaged With Audit and Feedback Reports
Authors: Rouleau Geneviève , Reis Catherine , Ivers Noah , Desveaux Laura
Published: November 2022

Background

In Ontario, Canada, a government agency known as Ontario Health is responsible for making audit and feedback reports available to all family physicians to encourage ongoing quality improvement. The confidential report provides summary data on 3 key areas of practice: safe prescription, cancer screening, and diabetes management.

Objective

This report was redesigned to improve its usability in line with evidence. The objective of this study was to explore how the redesign was perceived, with an emphasis on recipients’ understanding of the report and their engagement with it.

Methods

We conducted qualitative semistructured interviews with family physicians who had experience with both versions of the report recruited through purposeful and snowball sampling. We analyzed the transcripts following an emergent and iterative approach.

Results

Saturation was reached after 17 family physicians participated. In total, 2 key themes emerged as factors that affected the perceived usability of the report: alignment between the report and the recipients’ expectations and capacity to engage in quality improvement. Family physicians expected the report and its quality indicators to reflect best practices and to be valid and accurate. They also expected the report to offer feedback on the clinical activities they perceived to be within their control to change. Furthermore, family physicians expected the goal of the report to be aligned with their perspective on feasible quality improvement activities. Most of these expectations were not met, limiting the perceived usability of the report. The capacity to engage with audit and feedback was hindered by several organizational and physician-level barriers, including the lack of fit with the existing workflow, competing priorities, time constraints, and insufficient skills for bridging the gaps between their data and the corresponding desired actions.

Conclusions

Despite recognized improvements in the design of the report to better align with best practices, it was not perceived as highly usable. Improvements in the presentation of the data could not overcome misalignment with family physicians’ expectations or the limited capacity to engage with the report. Integrating iterative evaluations informed by user-centered design can complement evidence-based guidance for implementation strategies. Creating a space for bringing together audit and feedback designers and recipients may help improve usability and effectiveness.
Use of the Maslach Burnout Inventory Among Public Health Care Professionals: Scoping Review (Preprint)
Authors: Soares Juliana Pontes , Lopes Rayssa Horácio , Mendonça Paula Beatriz de Souza , Silva Cícera Renata Diniz Vieira , Rodrigues Cláudia Cristiane Filgueira Martins , Castro Janete Lima de
Published: November 2022

BACKGROUND

Work can be considered a source of living, well-being, and socioeconomic development. When the work environment negatively influences individuals, it may trigger emotional disturbances, behavioral problems, chronic stress conditions, and illnesses such as burnout syndrome (BS). Recently, studies on BS have increased and placed a special focus on health care professionals. The prevalence of BS among health professionals is associated with their chronic exposure to human hardship and long working hours without proper rest. These factors have contributed to greater stress and high physical and emotional exhaustion levels.

OBJECTIVE

This study aims to identify and map studies using the Maslach Burnout Inventory (MBI) scale to identify burnout syndrome in health professionals working in public health services.

METHODS

This scoping review was developed based on the Joanna Briggs Institute (JBI) Reviewers Manual and reported according to the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews). A total of 6 databases were searched to identify relevant studies: Embase, LILACS, MEDLINE or PubMed, PsycInfo, Scopus, and Web of Science. Gray literature was consulted on ProQuest Dissertations and Theses Global, Google Scholar, Brazilian Digital Library of Theses and Dissertations, and Open Access Theses and Dissertations. Additionally, the reference lists were searched to retrieve studies not previously selected. The steps followed in this study were proposed by Arskey and O’Malley and Levac, Colquhoun, and O’Brien: identification of research questions, identification of potential studies, study selection, data extraction and imputation, data analyses and interpretation, and consultation with stakeholders. The detailed methodology was published in a protocol.

RESULTS

A total of 55 articles were identified after screening for eligibility criteria, published between 1999 and 2021 in 32 countries. Most reports were published in Brazil, Spain, and China. A total of 22 versions of the MBI were identified, presenting different items, scores, and cutoff points. The included studies had recommendations and implications for clinical practice. The consultation with stakeholders allowed knowledge translation for those interested in BS.

CONCLUSIONS

Studies mostly included physicians (34/55, 61.8%) and nurses (24/55, 43.6%), and the original version of MBI was predominantly used. Divergences in BS classification were highlighted, which may be related to MBI cross-cultural adaptations and applications in other countries. This study contributes to the advancement of research regarding burnout syndrome as an occupational illness since it has harmful consequences for workers, health care services, and the quality of care provided to the population.
Healthcare and economic burden of anticholinergic use in adults with overactive bladder: a systematic literature review
Authors: Duperrouzel Corinne , Martin Coby , Mendell Ari , Bourque Megan , Carrera Adam , Mack Alicia , Nesheim Jeffrey
Published: November 2022

Aim:
To determine the economic burden associated with anticholinergic medication use in adults with overactive bladder (OAB) in the USA.
Methods:
A systematic literature review was conducted to identify articles assessing healthcare resource utilization (HCRU) and costs associated with anticholinergic use in adults with OAB.
Results:
From the 34 articles identified, increased anticholinergic burden, switching anticholinergic treatments and potentially inappropriate anticholinergic use were associated with increased HCRU and/or costs. However, studies comparing patients with OAB receiving anticholinergics to individuals with untreated OAB or without OAB reported a mix of increases and decreases in HCRU and costs.
Conclusion:
Additional controlled studies assessing the economic impact of anticholinergics in OAB are needed and may enable optimization of economic and potentially patient outcomes.
Twenty years of science communication: looking back, looking forward
Authors: Riedlinger Michelle , Joubert Marina
Published: November 2022

Our 20th anniversary this year is a special milestone for JCOM. It is a time to reflect on our past performance and future prospects. We pause to consider the activities of this journal, and the broad field of science communication over the past 20 years.
What is ‘‘science communication’’?
Authors: Lewenstein Bruce
Published: November 2022

The field of science communication goes by many names. This commentary explores the tensions between plain ‘‘science communication’’ and the more specific ‘‘public communication of science and technology’’. The commentary argues that science communication is not just one thing — and that’s okay.