bluuebunny/crossref_metadata_2025 huggingface dataset:
MAKALAH MANAJEMEN SUMBER DAYA MANUSIA
Authors: Amelia Kiki Rezky
Published: November 2021

Sumber daya adalah segala sesuatu yang merupakan aset perusahaan untuk mencapai tujuannya. Sumber daya yang dimiliki perusahaan dapat dikategorikan atas empat tipe sumber daya, seperti Finansial, Fisik, Manusia dan Kemampuan Teknologi. Sumber daya finansial merupakan salah satu unsur penting dalam rangka membentuk perusahaan yang maju dan terus berkembang karena berhubungan dengan saham yang merupakan modal utama dalam membangun sebuah perusahaan dan mengembangkan serta melanjutkan perusahaan tersebut. Sumber daya fisik merupakan sumber daya yang menyangkut penunjang secara fisik berdirinya suatu perusahaan seperti alat-alat kelengkapannya
E-Enviroment
Authors: Yangriani
Published: November 2021

Perkembangan teknologi yang sangat cepat pada dunia globalisasi dan banya keadaan lainnya yang eksternal memengaruhi daya saing dalam sebuah perusahaan. Di pasar ekonomi terdapat beberapa faktor seperti globalisasi, perkembangan teknologi baru, konsumen yang sensitive terhadap harga, internet, saluran distribusi, dan komunikasi baru yang mempengaruhi para wirausaha.Sebagai sbeuah hasil dari pengembangan e-enviroment, e-ecommerce, dan e-marketing juga ada orang-orang dari berbagai kelompok usia konsumen diantara pelaku dalam sebuah pasar yang mewakili berbagai generasi (Pre-boom, Babyb bom, X Generation, Net Generation, Next Generation). Setiap generasi memiliki pengalaman dan kebiasaan tersendiri dalam menggunakan e-market. Maka dari itu pengetahuan pengetahuan mengenai kekhasan perilaku e-market dari berbagai generasi yang berbeda sangat penting dalam sebuah kewirausahaan, Hal ini berguna dalam keberhasilan dalam operasi di pasar, dan juga untuk memahami perubahan dan tantangan yang diharapkan dimasa mendatang pada e-commerce.
Digital Business Strategy
Authors: Fernando Vincent
Published: November 2021

Persaingan di era di mana teknologi sudah menjadi hal yang lumrah sangatlah sulit dan ketat. Perusahaan yang tidak melakukan adaptasi dan penerapan teknologi digital dalam perusahaan di persaingan saat ini akan mengalami kesulitan dalam mendapatkan advantages dalam produktivitas, persaingan, juga dengan profitabiltas. Pengaruh dari teknologi digital tidak hanya mencakup hal-hal seperti mesin, software, hardware, dan lain-lain, namun strategi perusahaan juga terpengaruh oleh penerapan teknologi digital dalam perusahaan seperti halnya dalam cara mengelola sumber daya, meriset tren atau mempertahankan customer yang ada di pasar.
Ten simple rules for good research practice
Authors: Schwab Simon , Janiaud Perrine , Dayan Michael , Amrhein Valentin , Panczak Radoslaw , Palagi Patricia M. , Hemkens Lars G. , Ramon Meike , Rothen Nicolas , Senn Stephen , Furrer Eva , Held Leonhard
Published: November 2021

This paper aims to provide early-career researchers with a useful introduction to good research practices.
MAKALAH MANAJEMEN SUMBER DAYA MANUSIA
Authors: Pratama Muh.Andhika
Published: November 2021

Manajemen Sumber Daya Manusia merupakan perencanaan, pengorganisasian, pengkoordinasian, pelaksanaan dan pengawasan terhadap pengadaan, pengembangan, pemberian balas jasa, pengintegrasian, pemeliharaan, dan pemisahan tenaga kerja dalam rangka mencapai tujuan organisasi. Sejarah Manajemen Sumber Daya Manusia sebelum permulaan abad ke-20 manusia dipandang sebagai barang, benda mati yang dapat diperlakukan sekehendak oleh majikan, hingga saat ini peningkatan kualitas sumber daya masih terus dilakukan, karena meskipun suatu negara tidak mempunyai keunggulan komparatif yang baik, namun mempunyai keunggulan kompetitif, maka negara tersebut bisa lebih bersaing dengan negara lain. Pendekatannya Manajemen Sumber Daya Manusia yaitu dilakukan dengan pendekatan mekanis, pendekatan paternalisme, dan, pendekatan system social. Tahap pelaksanaannya yaitu recruitment (pengadaan), maintenance (pemeliharaan), dan development (pengembangan). Fungsi adanya MSDM yaitu perencanaan tenaga kerja, pengembangan tenaga kerja, penilaian prestasi kerja, pemberian kompensasi, pemeliharaan tenaga kerja, dan pemberhentian. Urgensi adanya MSDM yaitu karena MSDM berarti mengatur, mengurus SDM berdasarkan visi perusahaan agar tujuan organisasi dapat dicapai secara optimum, staffing dan personalia dalam organisasi, meningkatkan kinerja, mengembangkan budaya korporasi yang mendukung penerapan inovasi dan fleksibilitas
Dilution mistakes, overdoses, side effects in the era of the pandemic
Authors: Tabaee Damavandi Pardis
Published: November 2021

Dilution mistakes, overdoses, side effects in the era of the pandemic
PASAR DAN PEMASARAN
Authors: Yaqin Ainul
Published: November 2021

Dalam suatu pasar terdapat berbagai macam pembeli dengan Kebutuhan dan perilaku yang berbeda-beda. Oleh karena itu, sangat sulit bagi Suatu produk untuk menguasai pasar secara keseluruhan. Strategi yang umum Ditempuh adalah memilih segmen pasar tertentu yang dapat memberikanKedudukan yang paling kuat bagi produk bersangkutan. Strategi ini yang Disebut dengan market positioning. Menarik konsumenmelakukan pembelian, maka perusahaan harus bisa menerapkan suatu strategi pemasaran yang tepat sesuai dengan kondisi pasar yang dihadapi. Keberhasilanstrategi pemasaran dipengaruhi oleh beberapa faktor yaitu riset dan analisis pasar,keputusan tentang produk, penetapan harga, promosi, dan distribusi. Agar produkyang dipasarkan dapat berhasil, maka perusahaan harus menggunakan konsep pemasaran yang meliputi manfaat, mutu atau kualitas dan kepuasan antarakebutuhan dengan keinginan.
Antisipasi Risiko
Authors: Jannah Miftahul
Published: November 2021

Bisnis merupakan hal yang sangat penting dalam kehidupan manusia. Dengan adanya bisnis maka akan terbuka lowongan pekerjaan dan keinginan serta kebutuhan konsumen dapat terpenuhi melalui produksinya. Dalam dunia usaha atau bisnis tidak ada yang bebas dari risiko, yang perlu kita lakukan oleh pelaku bisnis adalah tindakan antisipasi agar risiko dapat diminimalkan kan dan tidak menimbulkan hal-hal yang diluar dugaan. Risiko dalam bisnis merupakan hal yang wajar dijumpai, hal ini karena adanya berbagai macam faktor yang mempengaruhinya, Jenis-jenis risikonya pun bermacam-macam maka dari itu seorang pelaku bisnis haruslah cermat dalam melihat serta mengatasi segala kemungkinann yang akan terjadi dalam usahanya, sehingga risiko dapat diminimalkan dan kehidupan perusahaan dapat maksimalkan dengan baik.
Expression of LINC00968 correlates with overall survival in normal-like breast cancer.
Authors: Mamoor Shahan
Published: November 2021

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer, and integrated these findings with unbiased examination of patient survival outcomes based on molecular subtype. We have previously found significant differential expression of the gene encoding long intergenic non-protein coding RNA 968, LINC00968, when comparing primary tumors of the breast to the tissue of origin, the normal breast and in the brain metastases of patients with metastatic breast cancer4. Here we demonstrate through analysis of human survival data that expression of LINC00968 in primary tumors of the breast is correlated with overall survival in patients with normal-like subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed non-coding RNA and patient survival outcomes influenced by PAM50 molecular subtype. LINC00968 may be of relevance to initiation, maintenance or progression of cancers of the female breast.
Pattern of oto-rhino-laryngological diseases in Khalwa (Quran boarding school) in Khartoum State – Sudan, 2018
Authors: Adam Mohammed Alsadiq Abdallah , Nourelddin Ahmed Abdulgadir , Koko Bakri , Ahmed Almegdad , Mahmoud Ahmed Abdallah Ali , Malik Elfatih
Published: November 2021

Background: Khalwa is a boarding school that specializes in teaching Quran and Islamic principles. Otorhino-laryngological diseases are very common in children, and the cause of considerable morbidity. They include a range of diseases from as simple as common cold to as disabling as hearing loss. This study aims to determine the pattern of ORL diseases in Mustafa Alfadni,Khalwa and more specifically to assess the presence of symptoms and signs of Ear, Nose and Throat diseases and to measure it’s prevalence among Khalwa students.Methods: this study was a cross-sectional facility- based study, carried out at Mustafa Alfadni Quran recitation (Khalwa) in suburb of Sharq alneel in Khartoum state. All of the students of this Khalwa were involved. Data was collected using a structured questionnaire composed of demographic data, medical and health history, clinical examination using check list followed by physical assessment by a tuning fork for weber’s and rhinne tests, otoscope. diagnosis was done by an Ear, Nose and Throat specialist. Statistical analysis was conducted using SPSS software.Results: 116 khalwa students aged between 6 and 24 years with mean of 13.7 +-2.7 years were involved. 10.4% of the respondents were complaining of ear pain, 7.8% were suffering from tinnitus, 18.1% complained of nasal obstruction, 6% of them were suffering from facial pain, 23% were complaining of sneezing. 18.8% of the respondents suffered from epistaxis and 14.7% of them had sore throat. Medical examination revealed that, 25.8% had ear wax. The tympanic membrane in 4.4% was retracted, in 1.8% was bulging and in 2.6% there was effusion behind it and it was perforated in 1.8%. Hearing loss was 20.8% as a conductive hearing loss, and 4.2% were found to have sensorineural hearing loss. 16% had tonsillitis, and 10.5% had otitis media.Conclusion: Khalwa students were suffering from ear discharge, sneezing, epistaxis and sore throat beside ear wax and tympanic membrane disturbance that complicated with hearing loss recommended to have health services and health education program in the Khalawi to decrease the suffering of otitis media and hearing loss and prevent its’ complication as well.
Dampak Pola Asuh Otoriter Terhadap Perkembangan Remaja
Authors: Tasuab Irna Ireni
Published: November 2021

Remaja adalah masa transisi dari kanak-kanak menjadi dewasa. Dimana remaja tidak bisa dikatakan anak-anak lagi, tetapi secara fisik remaja belum bisa dikatakan dewasa. Pada tahap ini perang orang tua dan pola pengasuhan sangat penting untuk mendukung pertumbuhan dan perkembangan remaja. Seperti apa orang tua mengasuh anak akan menentukan siapa dirinya ketika remaja. Tujuan dari penelitian ini untuk mengetahui dampak dari pola asuh otoriter terhadap perkembangan remaja. Penelitian tentang Dampak Pola Asuh Otoriter Terhadap Perkembangan Remaja mengunakan metode penelitian Studi Kepustakaan (Library Research). Metode penelitian kepustakaan merupakan teknik pengumpulan data yang berupa catatan, buku, makalah atau artikel, jurnal dan sebagainya. Hasil dari penelitian tersebut adalah pola asuh otoriter sangat berpengaruh terhadap perkembangaan remaja. Dimana dampak negatif lebih banyak dari dampak positifnya.
digital business strategy
Authors: lam christopher
Published: November 2021

Sekarang ini perkembangan teknologi menjadi sangat pesat di dunia yang bisa menjadikan semua orang menjadi tergantung kepada teknologi ini. hampir semua orang sudah melakukan segala jenis aktivitas mereka dengan memakai teknologi yang bisa membuat aktivitas mereka menjadi jauh lebih mudah dan memakan lebih sedikit waktu. Hampir semua bisnia pun juga memakai teknologi sekarang ini karena sudah dibuktikan bahwa teknologi sekarang tersebut membuat kegiatan bisnis menjadi lebih cepat dan efisien yang bisa membuat profit naik. Untuk memakai digital business ini juga diperlukan strategy untuk mengimplementasikannya. Kita harus memiliki modal yang cukup karena untuk bisnis digital bisa memakan banyak resources dan juga kita harus memikirkan juga biaya jangka panjang saat memakai digital business ini. Penting untuk diingat bahwa strategi digital adalah sebuah konsep dan sesuatu yaitu, strategi digital pada akhirnya harus mengarah pada pembuatan rencana atau peta jalan yang konkret. Meskipun kita dapat terus mengubah taktik spesifik yang telah diputuskan untuk dijalankan, kita juga harus memiliki komitmen yang jelas untuk memahami apa arti digital bagi perusahaan kita.
Differential expression of lipase E, hormone-sensitive type in cancers of the breast.
Authors: Mamoor Shahan
Published: November 2021

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding lipase E, hormone-sensitive type, LIPE, when comparing primary tumors of the breast to the tissue of origin, the normal breast. LIPE mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of LIPE in primary tumors of the breast was correlated with recurrence-free survival in patients with HER2+ subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. LIPE may be of relevance to initiation, maintenance or progression of cancers of the female breast.
LAPORAN EKB ES Cincau Pargoy
Authors: RAMADAENI NURFITRI
Published: November 2021

Sebagian besar orang tidak tau bahwa cincau merupakan bahan yang mudah didapatkan, selain harganya yang murah, cincau juga tersedia dimanamana dan sekarang sudah ada produk bubuk cincau yang dapat kita buat sendiri di rumah. Akan tetapi olahan cincau selama ini masih sebatas es cincau biasa karena itu kami mengembangkan olahan cincau ini menjadi sebuah komoditiyang menguntungkan. Cincau adalah minuman yang diantara isinya ada semacam agar-agar yang dibuat dari daun cincau. Agar-agar cincau serupa dengan gel yang diperoleh dari perendaman daun tumbuhan tertentu dalam air. Gel terbentuk karena daun tumbuhan tersebut mengandung karbohidrat yang mampu mengikat molekulmolekul air.
APPLICATION OF CONTEXTUAL TEACHING AND LEARNING TO INCREASE AQIDAH AKHLAQ LEARNING OUTCOMES
Authors: El-Ghifary Rifdah Ibtisam , Istiqomah Nurul , Sakka Abdullah
Published: November 2021

The purpose of this classroom action research is to enhance the result study of moral aqidah education with Contextual Teaching and Learning learning in 2nd grade students of MI Raden Rahmat. The form of this research is classroom action research consisting of two cycles, each cycle consists of four stages, namely planning, implementation, observation and reflection. As the research subject is a 2nd grade students of MI Raden Rahmat. In data collection, the method used as the main method is observation and test. Based on the results of research on the learning models application of Contextual Teaching and Learning to 2nd grade students of MI Raden Rahmat, with a total of 13 students have enhancement on the study result, which is before the action, only 30.81% of students studied thoroughly, and after the action became 100% of students studied thoroughly. Thus, it can be concluded that the learning model application of the Contextual Teaching and Learning is proven to be able to improve study result of moral aqidah education in 2nd grade students of MI Raden Rahmat
TEKNIS PENDAMPINGAN ANAK USIA 5-6 TAHUN DALAM PENGGUNAAN GADGET
Authors: Sairo Sriwahyuni
Published: November 2021

Secara umum, gadget merupakan alat elektronik yang berukuran relatif kecil dan memiliki fungsi khusus serta praktis dalam penggunaannya. Gadget memiliki pengaruh yang sangat besar dalam kehidupan manusia, karena dengan adanya gadget dapat mempermudah pekerjaan manusia, dan juga memberikan kemudahan bagi manusia dalam berinteraksi dengan orang lain.
The Omicron variant and potential predictions of secondary infections
Authors: Tabaee Damavandi Pardis
Published: November 2021

A perspective
PENERAPAN SAW-TOPSIS DALAM ANALISIS RASIO KEUANGAN UNTUK MENUNJANG KEPUTUSAN BERINVESTASI SAHAM
Authors: Paksi Angger Binuko
Published: November 2021

Investasi saham merupakan satu dari sekian banyak pilihan berinvestasi. Dalam berinvestasi saham dibutuhkan suatu analisis dan tindakan yang tepat agar seorang investor dapat berinvestasi sesuai kebutuhannya. Salah satu caranya dengan analisis fundamental. Analisis fundamental merupakan metode analisis yang menitikberatkan pada data-data kunci yang ada dalam laporan keuangan suatu perusahaan untuk menilai kinerja keuangan perusahaan. Penelitian ini bertujuan untuk merancang proses analisis fundamental saham berdasarkan analisis rasio keuangan, metode SAW dan metode TOPSIS. Analisis rasio keuangan secara umum meliputi rasio likuiditas, rasio solvabilitas, rasio aktivitas, rasio profitabilitas dan rasio pasar. Bilangan fuzzy digunakan dalam metode SAW dan TOPSIS untuk memberikan efektivitas dalam menentukan nilai matriks keputusan. Metode SAW digunakan untuk mencari nilai matriks ternormalisasi untuk setiap kriteria dan metode TOPSIS digunakan untuk mencari solusi/alternatif berdasarkan nilai matriks ternormalisasi. Kemudian rancangan diterapkan dalam bentuk sistem pendukung keputusan berbasis aplikasi web. Pengujian dilakukan dengan 30 data laporan keuangan pada sektor properti dalam periode 2013-2015. Dari hasil pengujian akurasi menggunakan korelasi pemeringkatan Spearman berdasarkan model Springate dengan data uji pada periode 2013-2015 didapatkan hasil rata-rata 90%.
GSLC 3
Authors: Ramadhan Nicko Ahmad Chani
Published: November 2021

Bisnis televisi terestrial tradisional di seluruh dunia saat ini sedang menurun, termasuk di Indonesia. Munculnya teknologi visual dan Internet mengganggu bisnis televisi dengan platform dan layanan hiburan baru, terutama aplikasi atau situs hiburan online. Interaktivitas dan keragaman konten menjadi kunci utama yang menarik pemirsa atau pengguna. Tulisan ini mengkaji masa depan dan tren bisnis televisi dengan menggali lebih dalam tentang keberadaan teknologi informasi yang terus berkembang di media baru.
Differential expression of acetyl-CoA carboxylase beta in cancers of the breast.
Authors: Mamoor Shahan
Published: November 2021

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding acetyl-CoA carboxylase beta, ACACB, when comparing primary tumors of the breast to the tissue of origin, the normal breast. ACACB mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of ACACB in primary tumors of the breast was correlated with recurrence-free survival in patients with luminal B subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. ACACB may be of relevance to initiation, maintenance or progression of cancers of the female breast.
Connecting the dots: Using a network approach to study the well-being spectrum
Authors: Van de Weijer Margot , Landvreugd Anne , Pelt Dirk , Bartels Meike
Published: November 2021

Many theories on the structure of well-being exist, but there is no consensus on how different well-being constructs fit into an overarching well-being framework. We sought insight into the structure of well-being using a psychometric network approach in a sample of Netherlands Twin Register participants. First, in a trimming sample of N=1343 participants, we examine potential item redundancy based on associations between satisfaction with life, subjective happiness, quality of life, flourishing, self-rated health, depressive symptoms, neuroticism, and loneliness items. Next, we fit the network in a estimation sample of N=759 participants, and examine the performance and accuracy of the network. Our final network consists of a positive cluster including satisfaction with life, subjective happiness, and flourishing items, and a negative cluster including depressive symptoms, loneliness, and neuroticism items. While items belonging to the same well-being measure clustered together, all well-being items were densely connected, re-affirming the complexity of the construct.
Relating psychiatric symptoms and self-regulation during the COVID-19 crisis
Authors: Vaghi Matilde M. , Hagen McKenzie Paige , Jones Henry Morrow , Mumford Jeanette , Bissett Patrick , Poldrack Russell
Published: November 2021

Disruptions of self-regulation are a hallmark of numerous psychiatric disorders. Here, we examine the relationship between transdiagnostic dimensions of psychopathology and changes in self-regulation in the early phase of the COVID-19 pandemic. We used data-driven approach on a large number of cognitive tasks and self-reported surveys in training datasets. Then we derived measures of self-regulation and psychiatric functioning in an independent population sample (N = 102) tested both before and after the onset of the COVID-19 pandemic, when the restrictions in place represented a threat to mental health and forced people to flexibly adjust to modifications of daily routines. We found independent relationships between transdiagnostic dimensions of psychopathology and longitudinal alterations in specific domains of self-regulation defined using the drift diffusion model. Compared to the period preceding the onset of the pandemic, a symptom dimension related to anxiety and depression was characterized by a more cautious behavior, indexed by the need to accumulate more evidence before making a decision. Instead, social-withdrawal related to faster non-decision processes. Self-reported measures of self-regulation predicted variance in psychiatric symptoms both concurrently and prospectively, revealing the psychological dimensions relevant for separate transdiagnostic dimensions of psychiatry, but tasks did not. Taken together, our study shows that self-regulation can be affected depending on the interaction between external events and trait-like vulnerabilities and suggests that the study of cognition needs to take into account the dynamic nature of real-world events as well as within-subject variability over time.
Intentional and Phenomenal attributions in the light of the influence of personality traits, and Attitudes towards robots on pro-social behaviour in human-robot interaction
Authors: Spatola Nicolas , Marchesi Serena , Wykowska Agnieszka
Published: November 2021

In the decades to come, robots could become more present in the human environment increasing the likelihood to interact with them. When reasoning about them, individuals tend to endow robots with human-like characteristics such as intentions or emotions, they develop attitudes toward them and differ in their likelihood to cooperate with them . However, how these different variables emerge, interact in the human mind and effect actual behaviour in HRI is still poorly understood. In three studies, using the intentional and phenomenal stance theoretical framework, the attitudes toward robots evaluation and the Big-Five personality traits framework we investigated the attribution of intentional and phenomenal experience to robots and the influence of imaginative representation robots on the interpretative attributions (Experiment 1). We also evaluated how the context of evaluation presenting robots with different level of human-likeness as potential social actors compared to mere technological prototypes and the prior attitudes toward them could bias intentional/phenomenal attributions (Experiment 2). Finally, we used a human-robot a prisoner’s dilemma game and developed a structural integrative model using attributions, attitudes and personality traits to evaluate the likelihood of participants to make a prosocial decision in HRI (Experiment 3).Experiment 1, 2 and 3 results showed that intentional stance is more readily adopted than phenomenal stance and that the imaginative type of the stances predicts the interpretative type. In experiment 2 level of attributions were predicted by attitudes toward robots. Also, attributions were influenced by robot human-likeness and the presentation of robots as social, compared to non-social, agents. Finally, experiment 3 structural integrative model showed a predominance of personality traits and attitudes to predict the likelihood to cooperate in an actual HRI.
Digital Transformations in Planning: An Australian Context
Authors: Ng Matthew Kok Ming , Pettit Christopher
Published: November 2021

Australia is currently undergoing sweeping changes in transforming and digitizing its planning and development sectors. However, numerous challenges still exist in consolidating and making accessible essential data in the country to effect evidence-based development policy-making. This has been argued to have tangible consequences in formulating solutions to urban problems, such as housing delivery, and driving new urban innovations that are data-focused. In this chapter, we discuss a new urban data governance model in the context of the development of a novel single housing data and analytics platform, which has been formulated based on Australia’s current issues on data disparity, ownership, and interoperability. This platform, the Australian Housing Data Analytics Platform, seeks provide researchers with an integrated data repository and transparent analytical capabilities that hopes to drive collaboration, public participation, and data democratization across the country. In line with PlanTech principles developed through the Australian Planning Institute, this chapter describes how data in Australia can be made as a public good and integral commodity for policy-makers for the better planning for our cities.
An Examination of India's Pharmaceutical Industry Through the Lens of Dependency Theory
Authors: AbuAlghanam Bashar
Published: November 2021

Dependency theory portrays certain countries as core countries and others as periphery countries. It portrays the relationship between the core and the periphery as a parasitic, and controlling, one. This paper examines global pharmaceuticals through the lens of dependency theory, which would predict that core countries try to exert control over the pharmaceutical industry in periphery countries through patents, licensing, capital controls or other means. They also extend their activities to conducting pharmaceutical testing of dangerous drugs in Third World (or periphery) countries. Evidence suggest that there is a history of major multinational pharmaceutical companies, which are headquartered in developed countries, monopolizing life-saving drugs and marketing unnecessary medical consumer products in periphery third world countries. The case of India, however, took a different discourse that cannot be fully explained within the framework of dependency theory; the Indian pharmaceutical industry has witnessed an impressive growth over the past several decades.
Application of digital technologies for sustainable product management in a circular economy – a review
Authors: Rusch Magdalena , Schöggl Josef Peter , Baumgartner Rupert J.
Published: November 2021

Digital technologies (DTs), such as the internet of things, big data, artificial intelligence or blockchain, are considered as enablers for a more sustainable and circular economy. So far, literature on these topics has mostly focused on specific DTs and sub-areas of sustainable product management (SPM). The aim of this paper is to provide a more comprehensive overview of current and potential examples of DT applications in SPM (e.g., product design/assessment, supply chain management, business models). The collected examples (n=146) were analyzed based on a systematic literature review, using quantitative and qualitative content analysis. Deductive and inductive analyses of the examples revealed the potential of DTs in terms of their useability along the product life cycle, their role as enablers for circular economy strategies and in specific SPM activities. DT application often entails only incremental improvements, e.g., increased efficiency of existing processes, with more radical forms of improvement remaining relatively scarce. There is clear room for greater adoption and optimization of DTs, in various areas of SPM, so as to accelerate the transition towards a more sustainable and circular economy.
مراجعة كتاب: نظام التفاهة لآلان دونو
Authors: عنيات عبد الكريم
Published: November 2021

عنوان الكتاب: نظام التفاهة.
عنوان الكتاب في لغته: La médiocratie.
المؤلف: آلان دونو.
ترجمة: مشاعل عبد العزيز الهاجري.
الناشر: دار سؤال للنشر.
مكان النشر: بيروت.
سنة النشر: 2020.
عدد الصفحات: 365 صفحة.
The Role of Mitochondria in Alzheimer's disease: Neurodegenerative Disease and Future Therapeutic Options
Authors: Angale Ruth
Published: November 2021

Mitochondria are cytoplasmic organelles responsible for life and death. Extensive evidence from animal and clinical studies suggests that mitochondria play a critical role in aging, cancer, diabetes and neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. Several lines of research suggest that mitochondrial oxidative damage is an important cellular change in most late-onset neurodegenerative diseases. Further, emerging evidence suggests that structural changes in mitochondria, including increased mitochondrial fragmentation and decreased mitochondrial fusion, are critical factors associated with mitochondrial dysfunction and cell death in aging and age-related diseases. In addition, epigenetic factors and lifestyle activities may contribute to selective disease susceptibility for each of these diseases. This paper discusses research that has elucidated features of mitochondria that are associated with cellular dysfunction in aging and neurodegenerative diseases. This paper also discusses mitochondrial abnormalities and potential mitochondrial therapeutics in AD. Alzheimer's disease (AD) is characterized by neuronal loss and gradual cognitive impairment. AD is the leading cause of dementia worldwide and the incidence is increasing rapidly, with diagnoses expected to triple by the year 2050. Impaired cholinergic transmission is a major role player in the rapid deterioration associated with AD, primarily as a result of increased acetylcholinesterase (AChE) in the AD brain, responsible for reducing the amount of acetylcholine (ACh). Current drug therapies, known as AChE inhibitors (AChEIs), target this heightened level of AChE in an attempt to slow disease progression. AChEIs have only showed success in the treatment of mild to moderate AD symptoms, with the glutamate inhibitor memantine being the most common drug prescribed for the management of severe AD.
Extradural Ependymoma Mimicking A Schwannoma: Case Report and Review of the Literature
Authors: H Bekralas , M Bouallag , N Habchi
Published: November 2021

Intracranial ependymomas are tumors derived from ependymal cells. In addition to the problems of excision posed by their location, intracranial ependymomas have a prognosis that is difficult to define because of the risk of recurrence or neurological dessimination at a distance from the initial focus. We report a clinical case of a patient operated in 2009 of an ependymoma grade II in right temporal, reoperated in 2014 for a grade III anaplastic ependymoma in the sacral region. This case has been studied in order to draw attention to this particular secondary localization of intracranial ependymoma.
Diagnosis Error of a Tuberculoma: Case Report and Review of the Literature
Authors: H Bekralas , N Habchi , M Bouallag , W Boulaouad , W Oumchiche , M Djaafer
Published: November 2021

Among the diagnoses to be mentioned before a brain tumor, that of tuberculosis, has retained a significant place in the developing countries. The extra axial form poses a real problem of differential diagnosis especially with meningioma. We report a case of a cerebral tuberculoma mimicking meningioma. A histological study is necessary in order to make a correct diagnosis and plan an adequate and early medical procedure.
Parkinson’s disorder: definitions, contexts, neural correlates, strategies and clinical approaches
Authors: Perrotta G.
Published: November 2021

Starting from the definition analysis of Parkinson's disorder, we proceeded to study the clinical, psychological and socio-environmental context, to better analyze the intrinsic and extrinsic aspects of this chronic progressive neurodegenerative pathology, placing emphasis also on secondary forms. The present contribution focuses in particular on all the most significant elements, also from an etiological and neurobiological point of view, in order to present the best therapies and treatments known today in medical and neuropsychotherapeutic profiles.
Differences Between a Birth Trauma and Compression Hypoxia
Authors: Vlasyuk Vasily
Published: November 2021

For a long time there is a problem of separation of hypoxia (asphyxia) and birth trauma. To resolve it, it is necessary to recognize this type of lesion as “compression hypoxia” and share it with a birth trauma. Morphological signs of differences between compression hypoxia and birth trauma, two forms of lesions caused by head compression, are given. The causes of death in birth trauma of the skull and the causes of intrapartum hypoxia are described. It has been shown that in many intranatally deceased children and newborns, intradural hemorrhages in the cerebellum are known, indicating head compression during labor.
Towards Quantification of Neurophysiological Intraoperative Monitoring variables, intraoperative analysis and post-surgical predictive importance
Authors: Valdés Sedeño Raúl Roberto
Published: November 2021

Due to the existence of papers that propose quantitative techniques [1-5] for Intraoperative Neurophysiologic Monitoring (IONM), the lack of concern about which could be right to refine the work of Neurophysiologist and Neurosurgeons and their great importance during and after surgical intervention
Brachysyndactyly due to Poland Syndrome
Authors: Hernandez-Fustes Otto Jesus , Arteaga Rodriguez Carlos , Hernandez-Fustes Olga Judith
Published: November 2021

A 49-year-old woman, was referred for electroneuromyography examination for paresthesias, pain and thoracic outlet syndrome hypothesis. The motor and sensory nerve conduction and electromyography were normal
A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management
Authors: Munshi S , Gendeh HS , Chaudhary AR , Kamath S
Published: November 2021

​​​Cocaine misuse has been in the news recently with the Department of Health in the UK, recognising the seriousness of its epidemic
Bipolar disorder: definition, differential diagnosis, clinical contexts and therapeutic approaches
Authors: Perrotta G.
Published: November 2021

Starting from the general concept of "bipolarity", the present work focuses on the essential aspects of the disorder defining the clinical and diagnostic contexts, laying the foundations for correct differential diagnosis, without neglecting the neural characteristics elaborated in the scientific community. The discussion concludes with the best therapeutic approaches suggested on the subject., hypothesizing that borderline disorder may be the evolution of bipolar disorder.
Why the wrong Scientific Theories are not Corrected and Re-evaluated again by Scientists
Authors: Hussein Al-Fleesy Othman Salim
Published: November 2021

In the journey of science and scientific discoveries, many scientific theories and hypotheses developed by scientists received acceptance and became famous in the past, but now, science proved them wrong1. To the point of wondering, one asks himself, how these theories went, and how scientists have accepted their interpretation at that time to be rejected now?.
The Geography and Demographics of Mortality from Alzheimer's disease
Authors: Kholmanskiy Alexander
Published: November 2021

Study nature of epidemiological risk factors and patterns of distribution of mortality from Alzheimer's (MA) in 160 countries. An exponential Malthus model was used to construct adequate approximations of statistical data. Proportionality of average lifetime after 55 years (Δt) to education index (Ψ) was established. Ranking of countries by increasing value of ΨΔt showed that MA depends exponentially on ΨΔt and all countries can be divided into three groups in accordance with level of their economic development. In series of countries of low, medium and highly developed, their average values of MA increase exponentially. Growth of MA in developed countries in post-industrial epoch was explained by emergence of a new risk factor Alzheimer's of a mental nature. A mismatch of complexity or, on contrary, primitiveness of profession with level of mental development of worker, provokes development of chronic stress in him, fraught with pathologies of cognitive function metabolism in elderly. The geography of Alzheimer's disease was explained by the dependence of the human mentality on latitudinal climate change and on the chiral factor of a solar nature acting at night on a sleeping person.
Ataxia Following Allogenic Stem Cell Transplantation: No Stone Unturned
Authors: Maurice Catherine , M. Pereira Austin , P. Mason Warren
Published: November 2021

A thirty-one year-old Sri Lankan man presented with a two-month history of progressive pan-cerebellar syndrome, following allogeneic stem cell transplantation. This curative-intent therapy was performed in the context of an underlying acute myeloid leukemia. During the post-transplant period, patients are extremely vulnerable, especially due to the immunologic fluctuations. Reaching equilibrium is crucial, preventing complications of both extremes of the immunologic response, such as opportunistic infections or graft versus host disease. Numerous aetiologies were considered in the differential diagnosis of this pan-cerebellar syndrome. Most of those conditions mandate a prompt management, because of their reversible or lethal nature. Our thorough investigation process was a race against time. Excluding “Red Flags” remains the priority. Mindfulness and time will eventually lead to the proper diagnosis. We discuss our structured investigation process emphasizing on the key element: a “Systematic Approach”.
Healing Noble Brains and Nobel Laureates as Peacemakers
Authors: Frischeisen Konrad
Published: November 2021

Saint Hildegard’s and Viktor Frankl’s healing methods and Split Brain Research inspired by Hildegard, Gerty Spies, Leibniz, Kant, Goethe, Schiller, Humboldt, Binnig & Co.
Diagnosis and Surgical Treatment of Orbital Tumors of Various Localizations and Histostructures.
Authors: Lystratenko O.I. , Kardash A.M. , Lystratenko D.O. , Vashchenko A.V. , Smyrnova O.F.
Published: November 2021

The article reviews and analyzes the results of treatment of 32 patients with orbital tumors operated in the clinic, neurosurgery until the period from 2015 till September 2019. Goals and objectives: coverage of clinical signs and symptoms, histology, diagnostic methods and treatment of patients operated on with orbital tumors during the period 2015-2019. Determination of optimal surgical approach to the tumors with different localization for performing the radical organ-preserving surgery, with maximal saving of visual functions, minimization of oculomotor disorders, patient disability. Materials and Methods: we analyzed the clinical cases of 32 patients undergoing treatment in DOKTMO with orbital tumors for the period from 2015 till September 2019. Patients were operated on with various approaches - transcutaneous, subconjunctive (without orbitotomy), fronto-orbito-zygomatic, pterional, subfrontal (neurosurgical approaches), transmaxillary, transethmoidal (ENT approaches). The choice of surgical approaches were individual. In 2 cases we become a backset of tumor growth: one patient with aggressive adenocarcinoma, after 18 months, leading to orbital exentration and the child, 9 years old with rhabdomyosarcoma after non-radical removal of tumors of subconjunctival approach. In all other cases, relapses were not detected, operation were organ-preserving oriented. Conclusions: the results of treatment of patients with tumors directly depend on the choice of radicality tumor removal, which is associated with the choice of surgical approach, chemical, radiation treatment in postoperative period depending on the histological response. From our point of view, the most universal method for tumor removal with various localizations and sizes is fronto-orbito-zygomatic approach which provides the performance of radical organ-preserving operation with maximal vision saving, minimizing oculomotor disorders, disability of the patient, despite its technical complexity for ophthalmologist surgeons. In this regard, surgery of orbital tumors is subject to the competence of doctors of related specialties.
Suicidal Risk: Definition, Contexts, Differential Diagnosis, Neural Correlates and Clinical Strategies
Authors: Perrotta Giulio
Published: November 2021

Starting from the concept of suicidal risk, this work re-elaborates the main theories on the theme and related theme of mourning, proceeding with a complete examination of the possible differential diagnoses and of the neural correlates involved, up to the most suitable clinical strategies to avoid the event of death.
CORONA VIRUS / COVID19 Practical advice for people with Ehlers-Danlos (hereditary connective tissue or collagen disease)
Authors: Hamonet Claude
Published: November 2021

These recommendations relate to patients who, despite their number, are rarely diagnosed or after a painful and dangerous medical wandering of 20 years on average.
Spinal Epidural Capillary Hemangioma: a Review
Authors: Lima Gibbon Frederico de , Gago da Silva Guilherme
Published: November 2021

The hemangiomas are benign vascular malformations. There are two types of hemangiomas that may affect the central nervous system, the cavernous type and the capillary type. The last is most uncommon and its presentation at spinal epidural space is extremely rare. These lesions usually present with signs and symptoms of myelopathy, radiculopathy or cauda equine syndrome. Magnetic resonance imaging (MRI) is the examination of choice and the treatment must be surgical regardless of the presentation of the patient due to the risk of spinal cord compression.
Global Workspace, Self, and Mathematical Intuition
Authors: Skopec Robert
Published: November 2021

In human consciousness a world of separated objects is perceived by an inner observer as an feeling of One-self. A topological correlation of the Self to the world, by either emerging all separated objects into one or splitting the Self in as many disconnected Sub-selves as there are objects perceived. The Self is generated in a neural network by algorithmic compression of spatial and temporal information into a toponeuronal structure (TNS). A correlation of an inner observer to parts of a structure inevitably entails a correlation to the whole, serving of the Self. Molecular mechanisms for the generation of a TNS in a neural network will be discussed.
The Effect of Caffeine Consumption on Fertilization and IVF Outcomes: A Review and Presentation of Original Data
Authors: L Yovich John , Zaidi Syeda , A Joesbury Karen , Lee Andy , M Hinchliffe Peter
Published: November 2021

Caffeine is widely consumed by both men and women but its pharmacological effects have not been well studied in the area of assisted reproduction. Various authorities indicate that caffeine consumption up to 400 mg per day is safe, but caution is advised for women who are, or are contemplating pregnancy and they should keep their intake under 200 mg per day. Our lifestyle studies at Curtin University showed adverse effects from caffeine consumption in both men and women. For men, fertilization rates were negatively associated with caffeine consumption (P<0.05) as well as IVF-related stress (P<0.005). Furthermore, caffeine negated the beneficial effect of male alcohol consumption, comprising mainly beer, on fertilization. For women, fertilization rates were negatively associated with caffeine consumption (P<0.005) and smoking history in years (P<0.001). However, our studies could not show any effect of caffeine consumption on the chance of pregnancy or miscarriage up to week 12 from either male intake (up to 4495 mg per week) or female intake (up to 2706 mg per week). We conclude that there is likely to be an effect from caffeine on one-Carbon metabolism and future studies need to interrogate the concomitant nutritional intake of B-vitamins and serum homocysteine levels, which can indirectly indicate deficiency or interference with this important metabolic pathway.
Single Dose of Methotrexate Therapy Followed By Suction Curettage for Management of Cesarean Scar Pregnancy
Authors: S Saleh Hend , E Sherif Hala , M Mahfouz Eman
Published: November 2021

Objective Implantation of the pregnancy in a cesarean scar is a rare condition named ; Cesarean scar pregnancy (CSP). Maternal complications can be prevented with the early diagnosis and an appropriate management .It is a Prospective clinical study to evaluate the efficacy and success rate of single dose use of methotrexate (MTX) followed by dilation and suction (D&S) regimen in management of women with cesarean scar pregnancy (CSP) . Methods 50mg of MTX in the form of a single dose Intramuscular injection then cervical dilatation and suction aspiration with a Karman cannula(D&S) under guidance of ultrasound after 48 preeceeded by vaginal misoprostol 2 tablet (200 mg) 4 hours ago. Results The mean gestational age at diagnosis was (8.5±1.6 ) and The mean level of serum b-human chorionic gonadotropin was (7424±2.560 ) and The mean gestational age of pregnancy was (8.5±1.6 ) .88.7% is the successive rate without complication need intervention, 2 (5.7%) patients needed intrauterine Foley's catheter for 24 hours as a mechanical hemostasis . 2 (5.7 %) had laparotomy with wedge resection of the gestational sac lesion and successful repair of the uterine defect and one (2.8 %)underwent subtotal hysterectomy. Conclusion: Systemic single dose MTX injection followed by D&S is an effective and harmless management for CSP. Nevertheless more studies are required to prove the efficiency, safety, and reproductive outcome of variant modalities in treatment of CSP.
Adolescent Mother and Child Abuse
Authors: Oliveros Donohue Miguel
Published: November 2021

Adolescence is the process that occurs after childhood and before adulthood (15-19) years. Teenage pregnancy is adverse for the mother and her child including low birth weight and high perinatal mortality. Complications between pregnancy and childbirth are the second leading cause of death among girls between the ages of 15 and 19 in the world. Violence against a pregnant woman by her partner is frequent. Adolescent mothers are among the greatest abusers of their children, and abuse can start from fetal life. They are also involved in the death of their newborns. Educational and community empowerment with a family response to educational proposals includes the issue of masculinity and the role of adolescents caring for their children, as well as examining the families' pleasure in the prevention and response to pregnancy.
COVID 19 in Pregnancy: Immunology Savior or Culprit
Authors: Kaur Brinderjeet
Published: November 2021

Corona pandemic has been a nightmare for health care, from the point of view of transmission, pathogenesis, diagnosis and treatment, everything in doldrums. Pregnancy in itself encompasses altered physiology, immunity and often is characterized by unpredicted bodily responses. The short review is an attempt to summarize the knowledge gained so far in context with COVID 19 infection in pregnancy. The paper highlights gaps in our present understanding and emphasize on more research for understanding the double edged sword - immune system and its response to COVID 19 infection in pregnant woman.