bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparing efficacy and safety of plasmapheresis versus atorvastatin in pathological progression of atherosclerosis in a rodent model
Authors: Zhang Jun , Tian Huawei , Li Yuping
Published: December 2021

Purpose: To evaluate the effect of plasmapheresis versus atorvastatin in pathological progression of atherosclerosis in a rodent model.Method: A total of 90 male adult rats of up to 300 g were randomly distributed in three groups (n = 30): group 1 (plasmapheresis up to 1.5 ml daily); group 2 (atorvastatin 0.1 mg/kg per day), and group 3 (hypercholesteremic rats). The following variables were assessed for 24 weeks: plasma and hepatic lipid and anti-oxidant profiles; atherosclerotic abrasions/lesions; coronary atherosclerosis/coronary stenosis score (CSS), composition of atherosclerotic lesions, incidence of xanthoma, arch and thoracic surface involvement including arch and thoracic area occupied by lesion; and thoracic aorta (I/M) ratio.Results: Compared to rats administered with atorvastatin, the rats treated with plasmapheresis had significantly greater improvement in levels of triglycerides (132 vs 124 mg/dl, p < 0.05), total cholesterol (201 vs 189 mg/dl, p < 0.05)), low-density lipoproteins (134 vs 123 mg/dl, p < 0.05)), very-low-density lipoprotein (11 vs 9 mg/dl, p < 0.05)) and high-density lipoprotein (36 vs 39 mg/dl, p < 0.05) levels. Plasmapheresis after 24 weeks of treatment improve CSS in all coronary arteries than atorvastatin (22 vs 24 respectively; p < 0.05. Furthermore, lesioned composition, I/M ratio and xanthoma incidence were significantly lower in plasmapheresis group than in atorvastatin group (p < 0.05).Conclusion: Plasmapheresis is a better alternative than atorvastatin in preventing pathological progression of atherosclerosis.
Combined administration of nicorandil and atorvastatin in patients with acute myocardial infarction after coronary intervention, and its effect on postoperative cardiac systolic function
Authors: Sun Zhirui , Zhang Yachao , Shen Yanxiang
Published: December 2021

Purpose: To study the effect of a combination of nicorandil and atorvastatin calcium in patients with acute myocardial infarction after coronary intervention, and its effect on postoperative cardiac systolic function of patients.Methods: Retrospective analysis was performed on 100 patients with acute myocardial infarctiontreated with coronary interventional therapy in The Third Affiliated Hospital of Qiqihaer MedicalUniversity from April 2019 to August 2020. The patients were randomised into control and study groups, with 50 patients in each group. The control group was treated with nicorandil, while the study group was treated with a combination of nicorandil and atorvastatin. Treatment response, cardiac structural indices, cardiac systolic function, blood lipid profiles, quality of life (QLI) score, Barthel Index (BI), Fugl- Meyer assessment (FMA), motor function score, incidence of adverse reactions, and blood pressure changes on days 1, 2, 3 and 4 after surgery, were compared between the two groups.Results: Treatment effectiveness, cardiac systolic function, QLI score, BI index and FMA motor function score in the study group were higher than the corresponding control values (p < 0.05). However, lower cardiac structure indices, blood lipid profiles and incidence of adverse reactions were greater in the study group than in the control group (p < 0.05). No significant disparity in blood pressure was found between the two groups on post-surgery days 1, 2, 3 and 4.Conclusion: The combination of nicorandil and atorvastatin calcium tablets produced better outcomes in patients with acute myocardial infarction after coronary intervention therapy; furthermore, the combination therapy significantly improved the cardiac systolic function of patients.
Prediction of steady-state plasma concentrations of olanzapine in Chinese Han in patients based on a retrospective population pharmacokinetic model
Authors: Wang Xiaoyue , Han Yong , Zhou Hong , Cao Bin , Zhu Miaomiao , Liu Chunfang , Gao Chao , McLeod Howard L , Fang Maosheng
Published: December 2021

Purpose: To develop robust methods of establishing a population pharmacokinetics (Pop-PK) model of olanzapine, using existing hospital in-patient information, in order to predict the steady-state plasma concentration of olanzapine tablets in Chinese Han inpatients, thus providing guidance for individualized therapy for mental disorders.Methods: A retrospective study analyzing and predicting the steady-state plasma olanzapineconcentration was performed using nonlinear mixed-effect modeling (Phoenix® NLME8). The effects of ten potential covariates, including age, gender, Body Mass Index, fasting lipid, family history, alcohol and smoking status in 107 Chinese Han patients with steady-state plasma olanzapine concentration were collected from the hospital information system (HIS) in Wuhan Mental Health Center from Feb 2017 to Jul 2019.Results: The final model was validated using bootstrap and visual predictive check (VPC) and was found to fit the one-compartment mixed error model. Smoking status was found to be the only factor affecting olanzapine tablets clearance. The standard Pop-PK parameters apparent volume of distribution (VL/F) and clearance (CL/F) were 223 L and 12.4 Lꞏh-1, respectively.Conclusion: The Pop-PK model for olanzapine established with the data from HIS is effective inpredicting the plasma olanzapine tablets concentration of individual Chinese in-patients. This Pop-PK model approach can now be adapted to optimize other antipsychotic drugs.
Resilience and adaptation to volcanoes in Late Middle Ages in Lipari island (Aeolian, Italy)
Authors: Maria Clara Martinelli  , Marco Manni  , Mauro Coltelli
Published: December 2021

Volcanic activity resumed during early Middle Ages times at Lipari following at least 6000 years of quiescence. This phenomenon occurred in a social context that had continuously developed from prehistoric times to the Roman age and was burdened by a demographic crisis that involved the archipelago between the 6th and 11th century AD. The rare archaeological records relating to the 6th - 11th centuries suggest abrupt changes in the population of the islands. The medieval sources are rich in religious and fantastic references to volcanic events linked to Lipari and Vulcano, testifying the uneasy condition for the human communities. This work concerns the resilience and adaptation of the communities to volcanic activity during the Late Middle Ages in Lipari. Starting from 1083 the Aeolian archipelago was involved in a repopulation program, implemented in 1095 by the Constitutum and organized by the Benedictine Monastery with the annexed S. Bartolomeo Cathedral on the castle. From the 13th century the volcanic phenomena, strictly limited to the northern sector of the island, did not interfere as previously with the anthropic activities. The Monastery will be enlarged in the Norman phase during the first half of the 12th century with the construction of the cloister. New historical documents relating to the 1264, report news of fires and land movements on Lipari. Recent age determinations obtained for the obsidian flow of Rocche Rosse at 1220 ± 30 AD (archaeomagnetic dating) and for an obsidian block of the Lami pyroclastic cone at 1243 ± 190 (fission-track dating) allow to define the age of the last phase of activity of the Monte Pilato-Lami-Rocche Rosse complex, and to associate it the events reported on 1264’s historical documents. This work makes in comparison volcanological, archaeological and historical dates and described an updated summary of one of the lesser known phases of the history of the archipelago. The main consequence of the medieval volcanic activity at Lipari caused a clear division of the territory with the population confined in the southeast quadrant, protected to the north by Serra and Monte Rosa which represented a natural orographic barrier.
Geomorphology and Prehistoric Settlements on a Volcanic Island: the Case of Ustica (Palermo, Italy)
Authors: Franco Foresta Martin  , Stefano Furlani
Published: December 2021

This study represents the first attempt to combine the geomorphological characteristics of the island of Ustica with the human settlements that have been established during prehistory, with the purpose of reconstructing the interactions between communities and the natural environment from the Neolithic to the Middle Bronze Age (6th - 1st millennia B.C.). Ustica is a small island in the Southern Tyrrhenian Sea, visible but far (~55 km) from the northern coast of western Sicily. Its rugged volcanic nature, remodeled and enriched by the sea, offered to the first colonizers a wide repertoire of opportunities and challenges. This island can be treated as an ideal “laboratory” to understand how settlers, taking their first steps towards the foundation of organized communities, were able to seize opportunities or succumb to obstacles. The review of archaeological research until now carried out in Ustica, integrated with geomorphological data and other biogeographical indicators, offers a picture of the prehistory of Ustica in which human presence is continuous and distributed in various sites of the island characterized by different physiographic characteristics. There are phases dominated by the choice of naturally protected sites and phases in which settlements expands on open land, suitable for agricultural use. Where the archaeological evidence is scarce, the geomorphological peculiarities allow us to decipher the vocations and characters of a human settlement. The study leads to an open question: in the Middle Bronze Age, after about five thousand years of uninterrupted habitation of Ustica, which factors, geological, social, or other, induced the early communities to abandon the island, without returning there for about eight centuries, until the Hellenistic-Roman age?
Foreword Special Issue: When volcanologists meet archaeologists and other disciplines
Authors: Mauro Antonio Di Vito  , Franco Foresta Martin  , Maria Clara Martinelli
Published: December 2021

This special issue of Annals of Geophysics entitled: “When Volcanologists Meet Archaeologists and Other Disciplines: Relationships Between Eruptions and Human Communities” originates from a session (S13) of the Rittmann International Conference which took place in Catania on February 13th 2020, having as its main theme the history of volcanology and the impact of volcanic activity on humans. The twelve articles collected in this special issue reflect the aims and contents of the reports presented by some participants at this session of the Rittmann conference
Antibiotic prophylaxis with amoxicillin to prevent infective endocarditis in periodontitis patients reconsidered: a narrative review
Authors: Hatz Christian R. , Cremona Mario ,  Liu Chun Ching , Schmidlin Patrick R. , Conen Anna
Published: December 2021

OBJECTIVES: To discuss first, the adequacy of the antibiotic prophylaxis regimen currently recommended for the prevention of infective endocarditis in periodontitis patients, and second, preventive measures to decrease the rate of bacteraemia after periodontal treatment.
MATERIALS AND METHODS: A bibliographic literature search identifying clinical trials between January 1990 and January 2021, focusing on microorganisms in bacteraemia after periodontal treatment and bacteria in infective endocarditis, was performed. Two reviewers independently identified and screened the literature by systematically searching in Medline/Premedline, EMBASE and Cochrane Library.
RESULTS: Two hundred and seventy articles were identified, of which twenty-three met the inclusion criteria. Bacteraemia rates after periodontal treatment ranged from 10–94% in the investigated patients. Mainly oral pathogens related to infective endocarditis, such as viridans group streptococci (up to 70%) and HACEK group pathogens (e.g., Aggregatibacter actinomycetemcomitans), were detected. But typical oral and periodontopathogenic species, such as Porphyromonas spp. (P.s gingivalis) (up to 50%), Actinomyces spp. (up to 30%) and Fusobacterium spp. (up to 30%), which do not usually cause infective endocarditis, were also found. Infective endocarditis episodes that might have been in association with a dental treatment were mainly caused by viridans group streptococci. Prophylactic measures like rinse application of chlorhexidine, povidone-iodine or essential oils, diode laser or systemic antibiotic prescription were described as decreasing the bacteraemia rate after periodontal interventions to 5–70%.
CONCLUSION: The currently recommended systemic antibiotic prophylaxis with amoxicillin before periodontal treatment in high-risk cardiovascular patients still covers the most common oral bacteria causing infective endocarditis, namely viridans group streptococci, and therefore seems adequate in this context. Since bacteraemia, not infective endocarditis, is the endpoint in most studies, the causality between bacteraemia after periodontal treatments and infective endocarditis remains difficult to elucidate. Until more evidence is available regarding this, adherence to current guidelines for antibiotic prophylaxis in patients at high risk for infective endocarditis undergoing periodontal treatment remains recommended.
Rural Community Perception of Tourism Development: A Strategic Tool in Rural Development
Authors: Litheko Alpheaus , Potgieter Marius
Published: December 2021

Local communities are the most valuable assets for a tourist destination; therefore, their perceptions of tourism constitute a crucial pillar for designing tourism development strategies that promote sustainable development. The success of tourism development in a rural setting depends on securing the support and active participation of stakeholders, in particular the community. It is important for planners to gather the perception of local communities about the impacts of tourism when planning the development of tourism. The aim of this study was to learn about the rural community’s perceived benefits associated with tourism development; and furthermore, to examine their attitude towards tourism development in their residential surroundings. Data was collected with the aim of gathering the community’s viewpoint, in particular their perception and attitude, on tourism development in a rural region, South Africa. The findings specify that the Local Destination Management Organisation (LDMO) and other role players should formulate development strategies that contribute towards creating employment opportunities and to develop an inclusive economy that will enable the local community to benefit through tourism development.
Destination Emotions, Loneliness, and Reasons to Travel: Predictors and Moderators of Tourism Well-being
Authors: Magano Jose , Leite Angela
Published: December 2021

This study aims to determine predictors and moderators of tourism well-being among destination emotions (DES) (total, joy, love, and positive surprise), loneliness (UCLA) (total, affinities, and isolation) and reasons to travel. Regression and moderation analyses were carried out; factor analysis (exploratory and confirmatory) to validate the emotions destination scale were performed. Marital status, family as a reason to travel, love (DES), positive surprise (DES), and affinities (UCLA) explain tourism well-being variance. Of the motivations for traveling, only family and work proved to moderate the relationship between DES and its subscales and tourism well-being. Traveling in Portugal or abroad was a moderator in the relationship between DES and its subscales and tourism well-being. The relationship between destination emotions and tourism well-being is stronger when people do not travel for family or work; this relationship is also stronger when people travel within Portugal than when traveling outside Portugal.
Gender Equality: Approaches and Strategies in University Context
Authors: Milenkova Valentina
Published: December 2021

This article is aimed at presenting a series of activities and systematic efforts that have found a place in the development of a Plan for Gender Equality in Research and academia. This endeavor is part of SPEAR project "Supporting and Implementing Plans for Gender Equality in Academia and Research“ under the EU Horizon 2020 Program: to develop specific approaches, activities, and measures systematized in Plans for gender equality to be implemented in the university environment, taking into account the specific national and regional characteristics of universities and structures. The SPEAR project involves universities and non-governmental organizations from 9 European countries: Denmark, Germany, Hungary, Sweden, Austria, Croatia, Portugal, Lithuania, and Bulgaria (SWU "Neofit Rilski” and PU “P. Hilendarski”). The article reveals the purposeful actions of the team from SWU "N. Rilski" in the direction of creating such a plan, which refers to several structural and organizational aspects. As a basis for the development of the Plan, the article shows the results of a quantitative online survey, which presents attitudes and opinions on the topic of gender equality in social activities and research, as well as the results of in-depth interviews with the SWU deans' and rector's authorities under the topic of women's participation in management and research activities. The article shows the importance of gender equality as an opportunity for active participation in research and teaching of capable and proactive people.
Ethnic conflict in Ethiopia: Federalism as a cause and solution
Authors: Bekele Bayu Takele
Published: December 2021

Adopted in 1991, ethnic federalism indeed paved the way for the recognition, accommodation, and institutionalization of ethnocultural diversity for the first time in the country’s history since its modern existence. What is equally important is, the practice of ethnic federalism complicated state-society and inter-group relationships creating a favorable environment for ethnic confrontation and conflict to take place in the country threatening national unity, eroded century-old values of coexistence, a hard ethnic boundary where administrative boundaries are served as political and ethnic differentiators like the Oromo and Somali conflict over contested boundaries. Territorial recognition, and institutionalization of ethnicity gave room for the emergence of ‘ethnic like and ethnic others’ thinking,  made minorities in different regions victims of politics and failed to provide sound accommodation mechanisms from them, severely restricted people’s constitutional rights including the right to mobility and right to work, created room for the re-emergence of secessionist tendency. Hence, ethnic federalism while solving old problems of ethnic inequality and injustice; has created new problems of ethnic tensions and conflict across Ethiopia. It is the purpose of this study to investigate how and why federalism is being considered as the source of ethnic conflicts in the Ethiopian context. The study adopted a qualitative comparative approach while FGDs and key informant interviews were used to gather data. The finding of the study shows that though multinational federation plays an irreplaceable role to accommodate and institutionalize ethnocultural diversity, the notion and implementation of federalism instigate ethnic conflict in the Ethiopian context.
La prisionización y los conflictos en el entorno penitenciario: investigación documental
Authors: Díaz Padilla Martha Vanesa
Published: December 2021

Las diversas experiencias en la vida nos permiten enfrentar situaciones que ponen a prueba la capacidad de adaptación al entorno; somos seres sociales que nos apropiamos y desarrollamos ciertas habilidades para incorporarnos en cualquiera de las instituciones socializadoras que nos relacionamos. Por lo que, el conflicto puede ser comprendido como inherente al desarrollo humano, las habilidades o herramientas psicosociales con que se cuenta, contribuyen en hacer frente hacia situaciones problemáticas, en la deliberación de toma de decisiones, tolerancia, gestión de conflictos, búsqueda de acuerdos y consensos para solucionar las controversias en cualquier área de nuestra vida. Lo anterior hace comprender que en todos los ámbitos que nos desempeñamos, incluyendo el sistema penitenciario, prevalece el mal abordaje de los conflictos, ya que, la inadecuada toma de decisiones incentiva el ambiente agresivo característico del entorno penitenciario y del proceso de prisionización. Al visibilizar la serie de conflictos y violencia en el sistema penitenciario podremos identificar las causas y las consecuencias que generan en la población privada de libertad. La premisa no es terminar con los conflictos ni tampoco habituarnos a ellos, sino fortalecer la gestión de conflictos y lograr soluciones pacificadoras mediante el diálogo y establecer acuerdos.
Promoción de habilidades socioemocionales para la resolución de conflictos y conductas de riesgo en adolescentes en condiciones de vulnerabilidad social
Authors: Morales Rodríguez Marisol
Published: December 2021

Las condiciones de vulnerabilidad social afectan el sano desarrollo de los individuos de diversas comunidades, pero en particular los adolescentes, constituyen una población de riesgo dados los cambios a los que se enfrentan, los cuales se agudizan en contextos adversos; por ello la necesidad de implementar acciones tendientes a disminuir conductas de riesgo que permitan enfrentarse eficazmente a los desafíos diarios y promover comportamientos adaptativos. El objetivo del estudio fue promover mediante una intervención, habilidades socioemocionales asociadas a la resolución de conflictos en adolescentes en condiciones de vulnerabilidad, para disminuir conductas riesgo, en particular la actitud ante drogas y alcohol. Basado en una metodología cuantitativa, se utilizó un diseño preexperimental; participaron 69 adolescentes escolarizados en un programa de intervención con duración de 3 meses; se utilizaron las escalas Tolerancia a la frustración, Autoeficacia, Conflictack, Resistencia a la presión de amigos para consumo de alcohol y cuestionario de actitud ante drogas. Los resultados muestran cambios significativos en Tolerancia a la frustración, Actitud ante drogas y alcohol y Resolución de problemas. Se concluye que, al desarrollar habilidades socioemocionales, los adolescentes aprendieron a enfrentar eficazmente situaciones problemáticas, mostrando una actitud de rechazo hacia el alcohol y las drogas y con ello, reduciéndose la probabilidad de involucrarse en adicciones.
Disposiciones, prácticas educativas y habitus. Posibles trayectorias de los egresados de Prepa en Línea
Authors: Galán Mireles Eva María
Published: December 2021

Por deseo o necesidad de continuar estudios de bachillerato, en México existe desde 2014 un servicio de modalidad a distancia como una opción para hacerlo. Los estudiantes inscritos comienzan la producción y reproducción de prácticas sociales y educativas promovidas de manera bidireccional, es decir desde, para y en el campo educativo específico, así como; desde, para y a través de los agentes involucrados, incorporando y/o ajustando (en distintos niveles acorde con sus capitales) predisposiciones que al egreso los posicionan/reposicionan con posibilidad de continuar su trayectoria social y educativamente. Con apoyo en la Teoría de la Economía de las Prácticas Sociales (TEPS) de Pierre Bourdieu, se establece como objetivo analizar la reconversión de los capitales de los estudiantes e implicaciones futuras a partir de su tránsito en Prepa en Línea, y se propone en un análisis crítico-reflexivo. Bajo este esquema, la posición/reposición que ocupan al término del plan de estudios, es distinta a la inicial. Por consiguiente, la protensión les permite trazar posibles trayectorias de su futuro inmediato, mismas que se pueden apreciar como: a) de superación (como aspiraciones a estudiar la licenciatura); b) de extensión (seguir estudiando en la modalidad virtual); c) de adaptación (para ajustar su ruta como el deseo de ingresar a la modalidad presencial); d) de ubicación (ingresar por una razón -académica, laboral, económica, familiar, etc.- y alcanzarla), y e) de retroceso (al no identificar ninguna utilidad o ajuste después de estar inmersos en Prepa en Línea).
Espacios: naturaleza, poder y género
Authors: Pacheco Costa Verónica , Marin-Conejo Sergio , Vahí Serrano Amalia
Published: December 2021

Presentación monográfico
Projeto portinari: Infâncias e cultura
Authors: Campos Deborah  de Freitas , Machado Kelly Regina dos Reis
Published: December 2021

A E. M. Prof.ª Elvira Lúcia Esteves de Vasconcelos tem como proposta desenvolver projetos anuais que aproximem os alunos da cultura popular e erudita através da apropriação de conhecimentos sobre a vida e obras de artistas e suas influências na sociedade, favorecendo a ampliação do capital cultural. Em 2014 o artista escolhido foi Cândido Portinari. Considerando a relevância deste para a cultura brasileira e seu reconhecimento mundial, nos dedicamos a conhecer parte de sua vida e suas obras, fazendo um paralelo das situações representadas pelo artista e o momento de desenvolvimento de nossos alunos. A apresentação aos alunos se deu forma variada, através de vídeos, contato com material impresso, leitura de livros e visitas virtuais a museus. A apropriação por parte dos adultos e das crianças dos conhecimentos revelados pela cultura popular brasileira através da vida e obra de Portinari foi o principal resultado alcançado através deste projeto.
Role of Osteitis in Chronic Rhinosinusitis: A Predictive Marker of Disease Severity?
Authors: Gupta Neelima , Parasher Ankit , Bhardwaj Rohit , Sharma Sonal , Bhatt Shuchi , Dr. H. C. Taneja Dr. H. C. Taneja
Published: December 2021

Introduction
Chronic rhinosinusitis (CRS) not only affects the overlying mucosa but also involve the underlying sinus bone termed as osteitis. The role of osteitic bone in severity and persistence of disease has received little attention. Thus understanding of this can help in formulating better treatment plan for CRS. We conceived this study with an aim to assess correlation of osteitis with severity of disease and short term disease outcome by examining the various parameters concerned with CRS.
Material and Methods
This prospective cohort study included 40 participants as clinically diagnosed CRS cases and 20 participants as controls. Various pre and post-operative parameters concerning CRS were assessed like pre and post-operative Sino-Nasal Outcome Test (SNOT) 20 symptom score, Lund-Kennedy endoscopy and Lund Mackay CT scores, bone density / Hounsfield unit (HU), radiological bone thickness and histopathological mucosal and bone grading. Correlation between osteitis and all these parameters were analyzed.
Results
Osteitis / bone grade was found to have statistically significant, moderate and positive correlation with the preoperative Lund and Mackay CT score and mucosal grade. The osteitis / bone grade was found to be weakly and positively correlated to the Lund and Kennedy score and weakly but negatively correlated to change in SNOT- 20 values (both statistically insignificant).
Conclusion
There are high chances of harbouring severe osteitis underneath high grade mucosal disease in CRS. Preoperative Lund and Mackay CT score can serve as a surrogate marker for osteitis. Symptomatic severity of disease does not correlate with osteitis. Osteitis affects disease outcome negatively.
Clinicopathological Profile of Sino-nasal Masses at a Tertiary Care Hospital: A Descriptive Study
Authors: Deosthale Nitin , Patil Priyal , Khadakkar Sonali , Garikapati Pavani , Dhote Kanchan , Dhoke Priti , Harkare Vivek , Deshmukh Abhaysinh
Published: December 2021

Introduction
The Sino-nasal mass is a common clinical entity. Although it has varied aetiology ranging from non-neoplastic to neoplastic, clinical presentation is overlapping that poses diagnostic dilemma. Objective of the study was to study the clinical profile of Sino-nasal masses in terms of demographic profile, clinical presentation and clinicopathological diagnosis.
Materials and Methods
A descriptive study was carried out at tertiary care hospital for 2 years. Clinically diagnosed cases of sino-nasal masses were included in the study. Previously treated cases, congenital lesions were excluded. Provisional diagnosis was made based on clinical and radiological evaluation. Diagnosis on histopathological examination was considered as definitive.
Results
Total of 75 patients were included in the study. Demographic data showed slight male predominance (M:F= 1.08:1), with most patients from age group 31-40 years (26.67%). Nasal obstruction was the most common presenting symptom. The number of patients with non-neoplastic lesion was 48; 17 patients had neoplastic benign lesions while 6 patients had neoplastic malignant lesions.
Conclusion
Large number of patients presents with trivial symptoms but need careful examination and appropriate diagnosis. Inflammatory lesions outnumbered neoplastic lesions in our study. Clinical suspicion and appropriate investigations can guide in timely intervention and management of these patients reducing the morbidity and mortality in these patients.
CONHECIMENTOS E CONCEPÇÕES DE PROFESSORES ACERCA DO PROCESSO DE ALFABETIZAÇÃO DA CRIANÇA COM DEFICIÊNCIA INTELECTUAL
Authors: Fraga Pereira Rose Mary , Victor Sonia Lopes
Published: December 2021

Objetiva-se analisar os conhecimentos e as concepções e as práticas de professores do Município de Vitória, Espírito Santo sobre o processo de alfabetização da criança com Deficiência Intelectual. Trata-se de um estudo de natureza qualitativa do tipo exploratório, tendo Vigotski como principal interlocutor. Para tanto, foram realizadas entrevistas semiestruturadas. Os resultados produzidos evidenciam que o Município tem investido em formação para essas profissionais, todavia ainda parece incipiente essa formação ou necessita ser revista para atender as demandas da ação pedagógica, com vistas à garantia dos processos de alfabetização, principalmente, junto aos alunos público-alvo da educação especial com Deficiência Intelectual.
Biblioteca Pública de Segovia
Authors: Santamaría Ramírez María Luisa
Published: December 2021

La Biblioteca Pública de Segovia abrió sus puertas en el nuevo edificio en enero de 2016. A lo largo de su historia, iniciada en 1836, ha pasado por vicisitudes y dificultades, alcanzando ahora una estabilidad propiciada por unas instalaciones adecuadas y una provisión de fondos ajustada a su gestión. Una biblioteca moderna al servicio de los ciudadanos y sus necesidades.
A administração dos Marqueses de Cascais em Itamaracá: capitães-mores e procuradores do donatário (1692-1763)
Authors: De Carvalho Barbalho Velez Luciana
Published: December 2021

A capitania de Itamaracá permaneceu como uma donataria em um período em que ocorriam progressivamente incorporações das capitanias hereditárias do Atlântico ao patrimônio régio, durante os séculos XVII e XVIII. A devolução da referida capitania à família donatarial dos Marqueses de Cascais ocorreu em 1692, permanecendo com a posse até a morte da última herdeira da Casa de Cascais, em 1763. Dentro deste contexto, o objetivo deste artigo é entender como os Marqueses de Cascais mantinham a administração de sua possessão à distância, através das nomeações para ofícios da administração colonial, sobretudo o ofício de capitão-mor, relativo ao governo da capitania, bem como de procuradores do donatário, muitas vezes coincidente com o de capitão-mor.
Transformational leadership and its impact on the job performance of high school teachers in fiscal educational institutions in the canton of Santa Elena
Authors: Ordonez Sequera Nora , Garcia Regalado Jorge
Published: December 2021

In the canton of Santa Elena, transformational leadership was studied and how it affects the work performance of high school teachers of public educational institutions, with the objective of knowing if it affects the functions of teachers and if this has repercussions on their low work performance or overloads the teaching staff. The research has a mixed approach under the deductive method. The fiscal institutions in the Santa Elena canton are located in the central area and have a total of six, with a total of 135 teachers. Leadership is directly related to the work performance of the teaching staff, which is evident in the fiscal educational units of Santa Elena, however, it is established that not all leaders have transformational leadership (LTF) for the performance of their duties, a situation that affects the development of the teaching staff positions.

Keywords: Transformational leadership, performance, teachers, organization, educational institutions.

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Analisis Penerapan Jual Beli Syariah pada Usaha Pedagang Kaki Lima (PKL) di Terminal Leuwiliang Kabupaten Bogor
Authors: Febrianti Salwa Aini , Junaedi Dedi , Sukarna Sukarna
Published: December 2021

This study aims to determine whether the street vendors at the Leuwiliang terminal know and apply sharia buying and selling in their daily marketing strategies and to find out whether the implementation of sharia buying and selling in their marketing strategies has an effect on the sales of street vendors. at Leuwiliang Terminal. To answer this question, the author uses descriptive qualitative research, namely an analysis of data that is explanatory and informational data that will be associated with theories and concepts that will be discussed in qualitative research and provide conclusions from this research. Data collection techniques used are observation, interviews, and documentation, the data sources used are primary and secondary data. Furthermore, data analysis consists of data collection, data reduction, data presentation, and drawing conclusions. Most of the street vendors in Leuwiliang Terminal Bogor do not know about buying and selling sharia, but when they are explained about buying and selling sharia and being asked again whether they apply sharia buying and selling in their daily buying and selling activities? The traders answered that they applied it in their daily buying and selling activities. And the street vendors at Leuwiliang Terminal are of the opinion that the implementation of sharia buying and selling has little effect on the sales of these street vendors.

Keywords: buying and selling sharia, marketing strategy, street vendors
Analisis Perilaku Konsumen Asuransi di Medan Sumatera Utara
Authors: Zahra Audina Rizka , Aslami Nuri
Published: December 2021

This research focuses on insurance consumer behavior, the factors that motivate insurance consumer behavior, insurance consumer behavior models, insurance consumer behavior models, insurance perceptions and insurance consumer decision-making processes. The method used in this study is a qualitative research method, namely a study that focuses on case knowledge through revealing accepted facts through interview and observation data. The results of the study obtained are to understand consumers, understand the consumption process, and improve one's personal ability to become an effective consumer. Understanding consumers and how they are consumed provides various uses, namely: helping managers to make decisions, providing researchers with a theoretical basis for researching consumers, helping legislatures and governments to legislate and make laws, and helping consumers to make better decisions. Then about consumers can help us to be able to master about the psychological, sociological, and economic factors that influence human behavior.

Keywords: Behavior, Consumer, Insurance
Theoretical Investigation of Some Radiation Shielding Parameters of Radiodiagnostic Agents
Authors: KAVUN Yusuf , TEL Eyyup
Published: December 2021

The impact of medical imaging in health services is increasing day by day. In this way, diseases can be diagnosed earlier and treatments can be carried out more effectively. As the use of medical imaging goes beyond diagnosis and reaches the areas of disease prevention and treatment, the costs of healthcare services on a global scale are also significantly reduced. In this study, radiation shielding properties of drugs such as C23H30GdN3O11 (Gadoxetic acid), C28H54GdN5O20 (Gadopentetic acid) and C20H12O5 (Fluorescein) used in imaging have been investigated. These radiation parameters include linear and mass attenuation coefficients (LAC, MAC), half and tenth value layers (HVL, TVL), mean free path (MFP), effective atomic number and electron density (Zeff, Neff) and effective conductivity (Ceff) energy by using Phy-X software. These data have been generated for 1 keV to 2 MeV energy region. According to the data obtained, it was seen that the data scattered up to 100 keV were compatible with each other after this energy value.
Trade Relations between Byzantion and the Black Sea Region in the Hellenistic Period: An Assessment through Recently Found Amphora Stamps
Authors: ÇAĞNİS Pınar
Published: December 2021

The rescue excavations undertaken on the European and Asian sides of Istanbul in recent years have revealed significant information regarding Byzantion, which had an active and strategic role in Hellenistic trade. A highly important part of the work in question was undoubtedly the excavations carried out within the scope of the Marmaray Project. A large number of artefacts and structures were brought to light throughout the excavations of the project at the Sirkeci station. Among these finds were amphora stamps which had previously been little known. The excavations uncovered finds that shed new light on the commercial relations between Byzantion and

two important cities in the Black Sea region - Chersonesus and Sinope. This study results from documenting these amphora stamps. Although these amphora stamps provide information regarding a limited geographical area within Byzantion, nevertheless, they provide some idea regarding the larger commercial relationships of the city.
A Group of Roman and Late Antique Bone Objects Found in Ancient Tralleis
Authors: ÜNAL Ceren , ÖZCİHAN İsmail , TOY Merve
Published: December 2021

Both ancient written sources and archaeological finds provide evidence that the ancient city of Tralleis was established on the plain of the southern skirt of Mount Kestane (Mesogis). The excavations performed at ancient Tralleis have unearthed the Gymnasium, the Northern and Western Workshops, the Western Necropolis, the Arsenal and the Villa Sectors, all of which are dated to the Roman era. Also uncovered is the Episcopal Church, which is dated to the Early Byzantine period. In this study, we will introduce a group of bone objects found in the excavations conducted in the Northern and Western Workshops of the Gymnasium and on the fill area at the exit of the Arsenal. The production of bone objects and workshops of ancient Tralleis will be evaluated. A total of 30 bone objects were unearthed during the excavation, and these were examined according to their forms and functions. In their preliminary evaluation we focused specifically on the role these bone objects played in the socio-economic structure of ancient Tralleis.
The Underwater Recovery Excavation at Kekova Adası: Observations on the Tek Ada Shipwreck and Finds
Authors: ASLAN Erdoğan , ERDOĞAN L. Ufuk
Published: December 2021

The Tek Ada Shipwreck was discovered during underwater surveys around Kekova Adası, which is located within the district of Demre in the province of Antalya. The shipwreck, first detected in 2015, had been damaged by illicit diggings in 2017. As a result of excavating some of the sand on it, some timbers from the shipwreck were exposed. This situation caused the decomposition of the ship to increase rapidly. For this reason, to understand the characteristics of the shipwreck and to determine

what necessary protective measures should be taken, studies were carried out within the scope of the “Kekova Adası Archeological Underwater Detection-Protection and Rescue Excavation Project” in 2018. During the excavation works, we observed that some of the timbers of the ship’s lower hull and its ballast have survived until today. The ship was built by using the frame-based method of construction. The Tek Ada Shipwreck is one of the rare shipwrecks on the Anatolian coast whose timbers have been preserved. These are thought to belong to the medieval period or later. In addition, around the shipwreck area and during the excavation, fragments from the ship in various forms and from different periods - made both of terracotta and lead and copper/ cooper alloy - were also identified.
State Immunity in Relation to Damage Caused by Legislation
Authors: Szász Viktória
Published: December 2021

Whenever we mention damage caused by legislation, the question arises if it is possible to talk about the liability of what defines the rules of liability. Is the civil court competent in deciding in these cases at all? It is doubtless that the concept of damage caused by legislation is on the threshold between public and private law, and immunity decides whether it is one or the other. More and more articles are written on the topic of damage caused by legislation, and their approaches to the root of the problem are all different. In this study, by analysing the issues of immunity with regard to damage caused by legislation, I try to reveal the past and present of regulations, and in this way the damage caused by legislation can be separated from the state’s functional immunity.
A román Polgári törvénykönyvről, hatálybalépésének tizedik évfordulóján
Authors: Veress Emőd
Published: December 2021

Romania’s Civil Code, which entered into force in 2011, is ten years old. It is essential to evaluate the codification results to assess the impact of the reform and the possible directions for its correction. The study reviews the circumstances and the objectives of the drafting of the Code. It draws attention to the positive aspects of the drafting of the Code and its innovative characteristics and points out several potential problems. It also indicates that the time is ripe for the first significant amendment following the entry into force of the Code. The Constitutional Court has declared unconstitutional the rule that a person who, because of mental retardation or insanity, lacks the capacity of discernment necessary to pursue his or her interests must be subject to a judicial interdiction. Instead of a judicial interdiction, a more equitable and gradual protection system for persons lacking the capacity to reason should be devised.
Scandia utblick: The history of Autism – an international research overview
Authors: Littmarck Sofia , Skagius Peter , Zetterqvist Nelson Karin
Published: December 2021

Denna 'Scandia utblick' diskuterar forskning om autisms historia i ett internationellt perspektiv.
Iskat-I Cenin (Çocuk Düşürme) Meselesi Hakkında Osmanlıca Dergilerde Yazılan Yazılar Uzerine Bir İnceleme (1867-1927)
Authors: MAYAK Faysal
Published: December 2021

İnsanlığın en eski dönemlerinden itibaren başvurulan çocuk düşürme eylemine Osmanlı Devleti’nde de hemen her dönemde rastlanmıştır. Nüfus olgusunun devletlerin güçlenmesi ve varlıklarını devam ettirmesi için önem kazanmaya başlamasından sonra çocuk düşürme olaylarına daha titiz tavırlarla yaklaşılmıştır. Osmanlı Devleti için de gerek inanç açısından gerek nüfus ve ekonomi perspektifinden çocuk düşürme meselesi ciddiyetle ele alınmış ve bu eylemin önlenmesi için çeşitli tedbirler yürürlüğe konmuştur. Özellikle matbaanın günlük hayata girmesi ve gazete ile dergi yayımcılığının başlaması, basının ıskat-ı cenin konusunda halkı aydınlatmak amacıyla kullanılmasını sağlamıştır. Türkiye Cumhuriyeti kurulduktan sonra da Türk toplumu arasında çocuk düşürme hadiselerinin devam etmesi bu dönemde de devleti tedbirler almaya itmiştir. Öte yandan dinamik ve taze bir nüfusa gereksinim duyan yeni devlet, gazete ve dergiler vasıtasıyla halkı çocuk düşürmenin çeşitli zararları konusunda uyarmaya çalışmıştır. Osmanlı Devleti’nde Sultan Abdülaziz, Sultan II. Abdülhamid ve II. Meşrutiyet dönemlerinde yayımlanan dergilere ek olarak Erken Cumhuriyet döneminin başlarında çıkan dergilerde ıskat-ı cenin konusuna temas edilerek halkın bu meselede davranışsal değişimine katkı sağlamak amaçlanmıştır. Bahsi geçen zaman aralığında çıkan Osmanlıca dergilerde, çocuk düşürme olayları, dini, ahlaki, ekonomik, psiko-sosyal, hukuki ve vicdani yönleriyle incelenmiş, bu alışkanlığı sürdürmenin bireylere ve topluma ne gibi zararları olacağı anlatılmaya çalışılmıştır. Mesele kimi zaman duygusal tepkiler ortaya konarak, çocuğunu bilerek düşüren annelere beddua tarzında sitemler dile getirilerek aktarılmışken kimi zaman bilimsel istatistikî veriler üzerinden somut delillerle değerlendirilmiştir. Bu çalışmanın amacı; Osmanlı Devleti’nde Sultan Abdülaziz döneminden başlayarak Erken Cumhuriyet dönemine kadar devam eden süreçte Osmanlıca olarak yayımlanan dergilerde ıskat-ı cenin olayının hangi açılardan ele alındığını göstermek, bu olay üzerinden toplumsal davranış alışkanlıklarına dair tespitlerde bulunmaktır. Buna ek olarak, söz konusu dergilerde çocuk düşürmeyi önlemeye yönelik ortaya konan öneriler üzerinden dönemin sosyal atmosferine ışık tutmak amaçlanmıştır.