bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of vascular parameters between normal cynomolgus macaques and healthy humans by optical coherence tomography angiography
Authors: Peng Jingyi , Zhong Liuxueying , Ma Li , Jin Jiayi , Zheng Yongxin , Jin Chenjin
Published: July 2019

Background: The metabolic activity of retina is higher than other human tissues and is crucial to the vision. Cynomolgus macaques is widely used in ophthalmic disease research. The evaluation and comparison of macular and optic disc vascular circulation parameters between normal adult cynomolgus macaques and healthy adult humans using OCT-A can promote better use of nonhuman primate models in studies of ophthalmic vascular disease. Methods: 12 normal adult cynomolgus macaques with a mean age of 4.91±0.43 years were studied for data collection. The macula of 28 adult healthy humans (14 males and 14 females), with a mean age of 25.11±6.21 years and the optic discs of 9 adult healthy humans (4 males and 5 females) with a mean age of 28.56±6.78 years were measured. The vessel density (VD) was measured using an RTVue XR with AngioVue. The scan sizes of the macular and optic discs were 3×3 mm and 4.5×4.5 mm, respectively. Results: OCT-A can image the superficial and deep capillary plexuses and radial peripapillary capillary network. In RPC layer of the optic disc, the VD in the nasal quadrant was lower than the VD in the inferior temporal quadrant. Similarities and significant differences in VD between healthy humans and cynomolgus macaques were obtained using OCT-A. Conclusions: This study provides normal vascular parameters for adult cynomolgus macaques using OCT-A to help establish an optical parameter database for cynomolgus macaques and compare VD between healthy humans and cynomolgus macaques to promote choroid-retinopathy research. Trial registration: Current Controlled Trials NCT03692169
Deletion of Tet proteins results in quantitative disparities during ESC differentiation partially attributable to alterations in gene expression
Authors: Reimer Michael J , Pulakanti Kirthi , Shi Linzheng , Abel Alex , Liang Mingyu , Malarkannan Subramaniam , Rao Sridhar
Published: July 2019

Background: The Tet protein family (Tet1, Tet2, and Tet3) regulate DNA methylation through conversion of 5-methylcytosine to 5-hydroxymethylcytosine which can ultimately result in DNA demethylation and play a critical role during early mammalian development and pluripotency¬. While multiple groups have generated knockouts combining loss of different Tet proteins in murine embryonic stem cells (ESCs), differences in genetic background and approaches has made it difficult to directly compare results and discern the direct mechanism by which Tet proteins regulate the transcriptome. To address this concern, we utilized genomic editing in an isogenic pluripotent background which permitted a quantitative, flow-cytometry based measurement of pluripotency in combination with genome-wide assessment of gene expression and DNA methylation changes. Our ultimate goal was to generate a resource of large-scale datasets to permit hypothesis-generating experiments.
Results: We demonstrate a quantitative disparity in the differentiation ability among Tet protein deletions, with Tet2 single knockout exhibiting the most severe defect, while loss of Tet1 ¬alone or combinations of Tet genes showed a quantitatively intermediate phenotype. Using a combination of transcriptomic and epigenomic approaches we demonstrate an increase in DNA hypermethylation and a divergence of transcriptional profiles in pluripotency among Tet deletions, with loss of Tet2 having the most profound effect in undifferentiated ESCs.
Conclusions: We conclude that loss of Tet2 has the most dramatic effect both on the phenotype of ESCs and the transcriptome compared to other genotypes. While loss of Tet proteins increased DNA hypermethylation, especially in gene promoters, these changes in DNA methylation did not correlate with gene expression changes. Thus, while loss of different Tet proteins alters DNA methylation, this change does not appear to be directly responsible for transcriptome changes. Thus, loss of Tet proteins likely regulates the transcriptome epigenetically both through altering 5mC but also through additional mechanisms. Nonetheless, the transcriptome changes in pluripotent Tet2-/- ESCs compared to wild-type implies that the disparities in differentiation can be partially attributed to baseline alterations in gene expression.
Zinc Content and Fruit Quality of Pecan as Affected by Application of Zinc Sulfate
Authors: Huang Ruimin , Shen Chao , Wang Susu , Wang Zhengjia
Published: July 2019

Pecan [Carya illinoinensis (Wangenh.) K. Koch] is an important nut tree species, and Zn nutrition is critical for its growth and nut production. The aim of this study was to provide a perspective on Zn accumulation in pecan fruit over time and to determine the effects of Zn application on fruit quality. Two concentrations of ZnSO4 (0.4% and 1.6%) were sprayed onto the shuck or the nearest pair of leaflets. Purified water was sprayed similarly as the control. The results show that Zn application to the shuck and leaves increased the Zn concentration and content in embryos. The greater the concentration of the Zn solution sprayed, the greater the Zn concentration in the embryo. The greatest zinc concentration in the embryo was found during the early stage of embryo development. In the treatment during which 1.6% ZnSO4 was sprayed onto the shuck, the Zn concentration in the early embryo was 242.91 mg·kg–1, which was 2.2 times that of the control. Thereafter, embryo Zn concentration decreased gradually until maturity. The treatments could be ranked, from greatest Zn concentration in the mature embryo to least, as follows: 1.6% ZnSO4 on shuck (66.36 mg·kg–1) > 1.6% ZnSO4 on leaflets (64.28 mg·kg–1) > 0.4% ZnSO4 on leaflets (55.51 mg·kg–1) > 0.4% ZnSO4 on shuck (49.67 mg·kg–1) > control (47.34 mg·kg–1). A model was presented that showed Zn was transported from the shuck and leaves to the stalks through the conducting tissue, and then to the embryo through the embryo sac. The application of 0.4% ZnSO4 to the shuck resulted in the greatest oil content (74.05%), which was 10% greater than that in the control. Applications of 0.4% ZnSO4 to the shuck and leaflets resulted in a greater proportion of oleic acid (≈69%) and a lower proportion of linoleic acid (≈20%), palmitic acid (≈6.0%), and linolenic acid (≈1.1%). The results of this preliminary investigation are useful for exploring the mechanism of action for Zn on pecans.
Intensity of Sole-source Light-emitting Diodes Affects Growth, Yield, and Quality of Brassicaceae Microgreens
Authors: Jones-Baumgardt Chase , Llewellyn David , Ying Qinglu , Zheng Youbin
Published: July 2019

Indoor farming is an increasingly popular approach for growing leafy vegetables, and under this production system, artificial light provides the sole source (SS) of radiation for photosynthesis and light signaling. With newer horticultural light-emitting diodes (LEDs), growers have the ability to manipulate the lighting environment to achieve specific production goals. However, there is limited research on LED lighting specific to microgreen production, and available research shows that there is variability in how microgreens respond to their lighting environment. The present study examined the effects of SS light intensity (LI) on growth, yield, and quality of kale (Brassica napus L. ‘Red Russian’), cabbage (Brassica oleracea L.), arugula (Eruca sativa L.), and mustard (Brassica juncea L. ‘Ruby Streaks’) microgreens grown in a walk-in growth chamber. SS LEDs were used to provide six target photosynthetic photon flux density density (PPFD) treatments: 100, 200, 300, 400, 500, and 600 μmol·m−2·s−1 with a photon flux ratio of 15 blue: 85 red and a 16-hour photoperiod. As LI increased from 100 to 600 μmol·m−2· s−1, fresh weight (FW) increased by 0.59 kg·m−2 (36%), 0.70 kg·m−2 (56%), 0.71 kg·m−2 (76%), and 0.67 kg·m−2 (82%) for kale, cabbage, arugula, and mustard, respectively. Similarly, dry weight (DW) increased by 47 g·m−2 (65%), 45 g·m−2 (69%), 64 g·m−2 (122%), and 65 g·m−2 (145%) for kale, cabbage, arugula, and mustard, respectively, as LI increased from 100 to 600 μmol·m−2· s−1. Increasing LI decreased hypocotyl length and hue angle linearly in all genotypes. Saturation of cabbage and mustard decreased linearly by 18% and 36%, respectively, as LI increased from 100 to 600 μmol·m−2·s−1. Growers can use the results of this study to optimize SS LI for their production systems, genotypes, and production goals.
Effect of Relative Air Humidity and High Temperature on the Physiological and Anatomical Responses of Two Rhododendron Cultivars
Authors: Ma Wenjie , Liang Wen , Zhao Bing
Published: July 2019

The effects of different relative air humidity (RH) levels under high temperature and accompanying vapor pressure deficits (VPDs) on the physiology, photosynthesis, and anatomy of Rhododendron need to be better understood to help in reducing damage to leaves caused by high temperature. In this study, two Rhododendron cultivars were exposed at 45%, 55%, 65%, 75%, and 85% RH to a treatment of constant temperature at 38 °C for 14 days, resulting in a VPD of 3.64, 2.98, 2.32, 1.66, and 0.99 kPa, respectively. The results showed the least reduction of the net photosynthetic rate (Pn) under 75% RH treatment in R. ‘Fen Zhenzhu’ (decreased by 79.8%), and under the 85% RH treatment in R. ‘Zhuangyuan Hong’ (decreased by 75.4%). The decline in relative water content (RWC) was less under the 75% and 85% RH treatments, and electrolyte leakage showed a slight decrease under the 75% RH treatment in the two Rhododendron cultivars. The appearance of the two cultivars under greater RH showed less damage, probably because plants can avoid damage by increasing total chlorophyll content, decreasing stomatal area, stomatal density, and opened stomata ratio, enhancing enzymatic activity and osmoregulation substances, and improving leaf structure. The findings show that greater RH can alleviate damage caused by heat stress and improve thermostability.
Identification and assessment of hazards for the electrical engineers and technicians at oil product warehouses
Authors:   Izhevsk state technical University named after M. T. Kalashnikov, Kostin Dmitry M. , Sevastyanov Boris V. ,   Izhevsk state technical University named after M. T. Kalashnikov, Shadrin Robert O.
Published: July 2019

Результаты работы получены в рамах НИР по гранту для ученых ИжГТУ им. М.Т. Калашникова № 20.06.01/18СБВ на тему «Разработка способов повышения эффективности систем управления охраной труда отдельных групп персонала промышленного предприятия». The research results were obtained as part of the grant research carried out by the researchers of Kalashnikov Izhevsk State Technical University № 20.06.01 / 18СБВ on "Development of ways to improve efficiency of labor protection management systems for individual groups of personnel of an industrial enterprise."
Peculiarities of calculation of the estimated time of evacuation of people using internal open stairs
Authors:   East-Siberian Institute of the Ministry of Internal Affairs of Russia, Sedov Dmitry V. , Shubkin Roman G. ,   East-Siberian Institute of the Ministry of Internal Affairs of Russia
Published: July 2019

The article deals with an issue of calculation of the estimated time of evacuation of people along open internal stairs located inside public buildings. According to mandatory regulatory requirements, the length of the escape route along such stairs is assumed to be equal to its tripled height. Implementation of this requirement when calculating the estimate time of evacuation is fraught with difficulties. The article solves the problem by conductng a numerical experiment using specialized software products to simulate the evacuation of people and experimentally determine the value of the speed modifier which ensures that the regulatory requirements are met.
A Case of Hairy Cell Leukemia Diagnosed Simultaneously with Lymphoplasmacytic Lymphoma by Anti-CD Antibody Microarray Method
Authors: Khvastunova Alina Nikolaevna , Al-Radi L.S. , Fedyanina O.S. , Lugovskaya S.A. , Kuznetsova S.A.
Published: July 2019

The paper deals with a combined case of hairy cell leukemia and lymphoplasmacytic lymphoma with IgMK paraprotein secretion. The use of anti-CD antibody microarray enabled the simultaneous assessment of immunophenotype as well as morphological and cytochemical analysis. Small populations of hairy (3 % of total lymphocyte count) and plasma (2 %) cells including Mott cells (0.2 %) were found in the peripheral blood of a patient with leukopenia. The results obtained by the anti-CD antibody microarray method speeded up provisional diagnosis which was later confirmed by standard diagnostic methods.
Experience with the Use of Thio/Mel Conditioning Regimen Prior to Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma
Authors: Gritsaev S.V. , Kostroma Ivan Ivanovich , Zhernyakova A.A. , Zapreeva I.M. , Karyagina E.V. , Chubukina Zh.V. , Tiranova S.A. , Martynkevich I.S. , Bessmeltsev S.S. , Chechetkin A.V.
Published: July 2019

Background. In multiple myeloma (MM) treatment a single autologous hematopoietic stem cell transplantation (auto-HSCT) is preceded by conditioning regimens aimed at intensifying cytoreductive effect. In the course of ongoing search for combined conditioning regimens an attractive option proved to be thiotepa/melphalan combination. Aim. Data analysis of a pilot study of the efficacy of conditioning regimens including administration of two alkylating agents (thiotepa and melphalan) with subsequent auto-HSCT. Materials & Methods. 9 patients received 10 auto-HSCTs with conditioning regimen including administration of 250 mg/m2 of thiotepa on Day -5 and 140 mg/m2 of melphalan on Day -2. After auto-HSCT pegylated filgrastim was administered in 8 patients. Engraftment period was calculated on the basis of absolute neutrophil count ≥ 0,5 x 109/L and thrombocyte level ≥ 20 x 109/L. Regimen toxicity was assessed according to CTCAE v5.0. Survival rates were estimated by Kaplan-Meier curves. Results. The use of thiotepa did not require administration of any additional drugs. The incidence of mucositis and enteropathy of grade 1-2 was 100 % and 70 %, respectively. Pyrexia was reported in 7 auto-HSCTs. Pneumonia occurred in 1 patient. The infusion of 1-3 doses of platelet concentrate (median of 2 doses) was required in all patients except for one. Donor erythrocytes were transfused to 3 patients. Engraftment was reported in all patients within the period of 10-14 days. Median hospitalization duration from Day 0 to hospital discharge was 16 patient-days. After auto-HSCT the quality of response improved in 6 out of 9 patients. MM progression was reported in one patient with complex karyotype. Further follow-up showed progression in 2 patients. By December 2018 median follow-up of 9 patients from the date of auto-HSCT was 9 months (range 3-20 months), me dian progression-free survival was 17 months, median overall survival was not reached. Conclusion. Acceptable toxicity, improvement of response quality, and maintenance of it for up to 20 months allow to consider combined conditioning regimen Thio/Mel to be a possible alternative to the standard Mel200 regimen.
Severe "Poor Graft Function" after Allogeneic Hematopoietic Stem Cell Transplantation in Adult Patients: Incidence, Risk Factors, and Outcomes
Authors: Rudakova Tat'yana Aleksandrovna , Kulagin A.D. , Klimova O.U. , Golubovskaya I.K. , Darskaya E.l. , Bykova T.A. , Smirnova A.G. , Morozova E.V. , Bondarenko S.N. , Moiseev I.S. , Beynarovich A.V. , Pevtsov D.E. , Alyanskii A.L. , Babenko E.V. , Barkhatov I.M. , Afanas'ev B.V.
Published: July 2019

Aim. Using strict criteria, to assess incidence, pretransplant risk factors, and outcomes of severe "poor graft function" (sPGF), following allogeneic hematopoietic stem cell transplantation (allo-HSCT) in adults. Materials & Methods. The study included 710 adult patients (median age was 31 years, range 18-70 years; 55 % male and 45 % female patients) with different hematological diseases and documented transplant engraftment after allo-HSCT from matched sibling (20 %), unrelated (67 %) and haploidentical (13 %) donors in the period from 2008 to 2016. Myeloablative and reduced-intensity conditioning regimens were administered in 30 % and 70 % of patients, respectively. The analysis was based on the following sPGF criteria: 2 or more lines of cytopenia (platelets < 20 x 109/L, absolute neutrophil count < 0.5 x 109/L, and hemoglobin < 70 g/L at any time after documented engraftment), complete or stable mixed donor chimerism > 90 %, and absence of relapse signs, rejection, and severe acute graft-versus-host reaction. The following factors were analyzed: age, sex, diagnosis, presence/absence of remission in acute leukemias, ferritin level, type of donor, HLA-match, blood group and sex match, graft source, number of transplanted CD34+ cells, and conditioning regimen. Multivariate analysis included parameters of univariate analysis with p < 0.05. Results. After allo-HSCT sPGF was identified in 103 patients with 2-year cumulative incidence of 15 % (95% confidence interval [95% CI] 12-18 %). In most cases sPGF developed during the 1st year after allo-HSCT (median 50 days). Bi- and trilineage cytopenia was found in 59 % and 41 % of cases, respectively. In multivariate analysis sPGF risk was associated with myelodysplastic syndrome, myeloproliferative disorders (hazard ratio [HR] 3.403; 95% CI 1.972-5.606; p < 0.0001), and haploidentical donors (HR 3.830; 95% CI 1.545-8.828; p = 0.001). The absence of remission at the time of allo-HSCT in acute leukemias and blood group incompatibility were of borderline significance. In almost half of the cases, sPGF had a poor outcome, including death from cytopenia-related complications, further relapses, and graft rejection. Prognosis of bilineage sPGF was more favorable than that of trilineage sPGF. Conclusion. The present large cohort study yielded the incidence and analyzed the structure of sPGF in adult patients with oncohematological diseases. In addition, the key pretransplant sPGF risk factors were identified. The results of the trial can serve to optimize the choice of therapy after allo-HSCT.
FAKTOR YANG BERHUBUNGAN DENGAN RAWAT INAP PADA PASIEN PEMBESARAN PROSTAT JINAK DI RUMAH SAKIT BHAYANGKARA MATARAM
Authors: Krisna Daniel Mahendra , Maulana Akhada , Kresnoadi Erwin
Published: July 2019

Latar Belakang: Pembesaran prostat jinak atau Benign prostatic hyperplasia

(BPH) merupakan kasus dengan insidensi yang tinggi terutama pada usia diatas 50 tahun di Indonesia. BPH menjadi penyakit yang menyebabkan rasa ketidaknyamanan dan menimbulkan keluhan yang sangat mengganggu kualitas hidup pasien. Berbagai pilihan terapi tersedia baik herbal, medikamentosa, maupun terapi operatif. Standar baku untuk BPH adalah terapi operatif yang membutuhkan rawat inap di rumah sakit. Tujuan: Untuk mengetahui faktor yang berhubungan dengan lama rawat

inap dan komplikasi sehingga dapat menekan biaya pasien. Metode: Delapan puluh sembilan pasien BPH dengan operasi TURP di RS Bhayangkara Mataram sejak bulan Januari 2010 - Desember 2014 diteliti berdasarkan usia, lama rawat inap, waktu tunggu operasi (WTO), lama rawat paska operasi, dan keadaan kateter ketika keluar rumah sakit melalui rekam medis. Jenis penelitian adalah penelitian analitik dengan metode cross sectional. Analisis statistik

dengan koefisien korelasi (r) Pearson dan Spearman rho.

Hasil: Dari 89 pasien kelompok usia terbanyak pada rentang 61-70 tahun (43.8%) dengan usia rata-rata 65, 75, usia termuda adalah 46 tahun dan usia tertua adalah 89 tahun. Memiliki lama rawat inap 5.53. Paling banyak 5 hari sebanyak 34 orang (38,2%). Rata-rata memiliki WTO 1,80 hari dan paling banyak memiliki lama

rawat inap selama 1 hari sebanyak 51 orang (57,3%), serta rata-rata memiliki lama rawat inap paska operasi 3,72 hari. Tidak ada korelasi antara lama rawat inap

dengan usia pasien (sig > 0,05; r = 0,121), komplikasi paska operasi pasien (sig > 0,05; r = 0,037) dan dengan keadaan kateter ketika keluar rumah sakit (sig < 0,05; r = -0,335**). Terdapat korelasi kuat yang signifikan antara lama rawat inap dengan WTO (sig < 0,05 ; r = 0,727**). Kesimpulan: Adanya berhubungan penyakit yang menyertai adalah

penyebab pemanjangan WTO. Tidak terdapat korelasi antara lama rawat inap

dengan dengan usia dan komplikasi paska operasi pasien, dan didapatkan korelasi kuat yang signifikan antara lama rawat inap dengan WTO. Lama rawat inap diatas rata-rata disebabkan oleh masalah pre-operasi.
SITOTOKSISITAS EKSTRAK ETANOLIK CURCUMA LONGA PADA SEL HeLa, STUDI IN VITRO
Authors: Kurniawan Chandra , Siagian Jonathan Willy , Hutomo Suryani
Published: July 2019

Kunyit (Curcuma longa) merupakan tanaman yang dapat tumbuh di daerah

tropis dan sub tropis. Di Indonesia, kunyit menyebar secara merata di seluruh

daerah. Kurkumin yang merupakan unsur utama kunyit. Penelitian terdahulu

melaporkan bahwa kunyit memiliki kandungan kurkumin yang terbukti secara

klinis memiliki efek antioksidan, anti-inflamasi, antiproliferasi, dan sitotoksik

sehingga mampu menginduksi apoptosis pada sel-sel keganasan darah, payudara,

colon, sel hati, dan ovarium, dengan sensitivitas setiap sel terhadap kurkumin

yang berbeda-beda.

Tujuan penelitian ini adalah untuk mengkaji efek sitotoksik ekstrak etanol

Curcuma longa yang didapatkan dari daerah Bantul pada sel HeLa. Sel HeLa

merupakan cell line yang telah dikultur dan dikembangkan dari sel epitelial kanker

leher rahim yang digunakan untuk berbagai kepentingan penelitian. Sel HeLa (2

x104 sel/well) dikultur dalam RPMI 1640 semalam sebelum stimulasi. Ekstrak

etanol kunyit dengan berbagai konsentrasi ditambahkan pada kultur HeLa dan

diinkubasi selama 24 jam dalam medium tanpa antibiotik. Analisis sitotoksisitas

dilakukan dengan menggunakan metode MTT assay. Doksorubisin (0,5625 μg/ml)

digunakan sebagai kontrol positif.

Hasil penelitian menunjukkan bahwa ekstrak etanol Curcuma longa

menyebabkan kematian sel sebesar 50% (IC50) pada konsentrasi 184,5 μg/ml.

Disimpulkan bahwa ekstrak etanol Curcuma longa bersifat sitotosik pada

sel HeLa, sehingga dapat dikembangkan agen kemopreventif.
UJI POTENSI ANTIBAKTERI KOMBINASI EKSTRAK AIR ALLIUM CEPA L DAN ANDROGRAPHIS PANICULATA NESS TERHADAP PSEUDOMONAS AERUGINOSA
Authors: Situmeang Merliana Sari , Hutomo Suryani , Suryanto Yanti Ivana
Published: July 2019

Bawang bombay (Allium cepa L) dan sambiloto (Andrographis paniculata

Ness) merupakan tumbuhan yang sering kita jumpai di sekitar kita. Allium cepa L

dan Andrographis paniculata Ness secara terpisah telah diteliti dapat menghambat

pertumbuhan Pseudomonas aeruginosa. Penelitian dilakukan untuk mengetahui

potensi antibakteri kombinasi Allium cepa L dan Andrographis paniculata Ness

terhadap bakteri Pseudomonas aeruginosa. Kedua tanaman tersebut diekstraksi

dengan metode infusa menggunakan pelarut air. Uji daya hambat dilakukan

menggunakan metode difusi dengan mengukur diameter zona hambat. Penelitian

pendahuluan dilakukan untuk menentukan konsentrasi terendah yang sudah

memiliki zona hambat dan didapatkan konsentrasi 25% untuk masing-masing

ekstrak, maka konsentrasi inilah yang digunakan sebagai kombinasi. Data yang

diperoleh dianalisis dengan menggunakan uji One Way Anova kemudian

dilanjutkan dengan uji LSD. Hasil penelitian menunjukkan bahwa terdapat

peningkatan zona hambat yang signifikan secara statistik (p = 0,00, p < 0,05) pada

kombinasi Allium cepa L dan Andrographis paniculata Ness dibanding sediaan

tunggal. Kesimpulan penelitian ini adalah terdapat peningkatan potensi

antibakteri terhadap bakteri P. aeruginosa.
Formation of Provisional Government Bodies in Dagestan
Authors: Salikhova Leila B.
Published: July 2019

The study features the formation of the Provisional Government bodies in Dagestan during the revolutions and Civil War, such as the Provisional Regional Executive Committee and the Commissars of the Dagestan region. The research was based on the principles of historicism and objectivity, which allowed the authors to determine the reliability of the used historical sources. The consequences of the February revolution in Russia affected the Dagestan region. During this period, various organizations struggled for power: the Council of Workers' Deputies, the Council of Soldiers' and Officers' Deputies, religious societies, Muslim committees, millicommittees, etc. However, the military governor was rep-laced by the Provisional Government, which had existed until April-May 1918. The Provisional Regional Executive Committee was formed in March 1917. Subsequently, it transformed several times. New commissars replaced former chiefs in the districts of the Dagestan region. The population of the region, which initially distrusted the elections, gradually began to get involved in the political process. The bodies of the Provisional Government included the Commissars of the Dagestan region. They had a lot of internal conflicts, as well as an open political confrontation with the Provisional Regional Executive Committee. These disagreements prevented effective work. The results of the research can be used in further study of the issue, in general studies on the matter, in a course of Dagestan history, or special courses on the history of the revolution and the Civil War.
Anthroponyms in Fantasy Fiction and Computer Games: Approaches to Translation
Authors: Fomin Andrei G. , Chobotar Vladislav I.
Published: July 2019

The following article examines the ways of translation of anthroponyms from English to Russian in fantasy fiction and computer games. The purpose of the study is to analyze and compare the anthroponyms translation variants in the literary text. In the following article works of Russian and foreign scientists in the context of anthroponimics were used, the usage of classification models was taken up, comparative analysis and functional analysis were used. The following study can be used in textbooks, in the process of translation and localization of fantasy fiction and computer games. The research material involves translations of anthroponyms of fantasy literature cycles (Harry Potter, The Song of Ice and Fire, The Lord of the Rings) and fantasy role-playing computer game "World of Warcraft". Particular patterns of anthroponyms translation were shown in terms of early and modern translations.
Magnitude, Characteristics, Maternal and Feto-Neonatal Outcomes of Obstetric Emergencies in Western Ethiopia, Nekemte, Ethiopia
Authors: Woyessa Ashenafi Habte , Caffo Jote Markos , Palanichamy Thanasekaran
Published: July 2019

Objective: In Ethiopia very little or probably nothing is known about the significance of obstetric emergencies. This study was therefore aimed at assessing magnitude, characteristics, and outcomes of obstetric emergencies in western Ethiopia.Study Design: Institution based prospective cohort study was employed from January to June 2017. To select the hospitals, area sampling technique was used. Total of 567 pregnant women with obstetric emergencies presented and treated in respective hospitals during the study periods and met the inclusion criteria were consecutively included.Results: Majority (91.7%) of the identified obstetric emergencies have led to termination of pregnancy. Significant proportions of pregnant women (11%) who reached health facility died of obstetric emergencies. Pregnant women with obstetric emergencies traveled to facility carried by people were found to have died about 8 times more likely as compared to those who were transported by ambulance. While 29.21% of women gave birth to normal life births, stillbirth and neonatal death were 8.02% and 7.4% respectively. Higher number of neonatal death was also observed among mothers in whom final mode of delivery was a cesarean section (AOR: 0.19(0.05, 0.62)) compared to spontaneous vaginal delivery.Conclusion: This study has revealed that obstetric emergencies are responsible for the significant number of maternal and perinatal death. If the women have been accessed early and received optimum emergency care, many cases of the occurred death would have been prevented. Better outcome can be achieved through maximum utilization of quality and comprehensive antenatal care and organized pre-hospital obstetric emergency services.
Removal of chemical oxygen demand (COD) and heavy metals by catalytic ozonation–microbial fuel cell and Acidithiobacillus ferrooxidans leaching in flotation wastewater (FW)
Authors: Bian Zhenzhong , Feng Yali , Li Haoran , Du Zhuwei
Published: July 2019

A catalytic ozonation–microbial fuel cell and Acidithiobacillus ferrooxidans leaching process was used in treating flotation wastewater to remove chemical oxygen demand (COD) and heavy metals in this study. The results indicated that when adding 1 g/L of manganese/modified activated carbon catalyst and 1.5 g/min ozone flow, the COD could be degraded from 2,043.67 mg/L to 711.4 mg/L. After that, the COD could continue decreasing down to 72.56 mg/L through an air-cathode single chamber microbial fuel cell (SCMFCs), coated with 0.4 mg/cm2 platinum catalyst, after 15 days. Meanwhile, the maximum voltages and the ultimate power density of the SCMFCs reached 378.96 mV and 7,608.35 mW/m2, respectively. For filter residue, when 1.2 g/L Fe3+, 10% (m/v) filter residue, and 10% Acidithiobacillus ferrooxidans were added, the copper leaching rate could reach 92.69% after 7 days if the pH values were adjusted to 1.9. Furthermore, the other heavy metals were also decreased to a level lower than the pollution control standard (Chinese standard GB3838-2002). The leaching parameters in terms of pH, redox potential, and cyclic voltammetry showed that the addition of an appropriate concentration of Fe3+ to the leaching systems was beneficial to copper dissolution.
El espectro de ciudades santuario en Estados Unidos: Los contrastes en la génesis y las prácticas de las políticas locales proinmigrantes
Authors: Cruz Lera Estefanía
Published: July 2019

Las denominadas ciudades santuario son actualmente la principal fuente de oposición a las políticas federales antiinmigrantes en Estados Unidos. El argumento central de este estudio cross caso, es que la categoría santuario aglutina un conjunto de leyes, políticas y prácticas informales de diferente naturaleza, con génesis políticas variadas y con diferentes grados de insurgencia. Este artículo sostiene que el estudio a profundidad del contexto en el que se enmarca cada tipo de santuario puede explicar la existencia de un espectro tan contrastante. Para diferenciarlas se proponen tres categorías representativas dentro del espectro: los santuarios de retórica, los santuarios de facto y los santuarios de bienvenida. Este estudio concluye que las prácticas santuario más representativas —con mayor insurgencia y grado de escalabilidad— están ligadas a la necesidad de la ciudad de defender su acceso a fondos y proteger su autonomía política; pero también, a la capacidad de los migrantes organizados para hacer alianzas con actores políticos locales.
El legado de la retórica clásica en la Defensa del general Nariño ante el primer Senado de Colombia en 1823
Authors: Suárez Pineda Jesús Alberto
Published: July 2019

El artículo discute que el legado de la retórica clásica en la Defensa del general Nariño ante el primer Senado de Colombia, en 1823, tuvo orígenes tomistas, es decir, proviene del pensamiento político de la escolástica. La evidencia documental se estudia mediante el análisis crítico del discurso, con el propósito de hacer explícito lo implícito: la defensa del honor de Nariño como hombre de Estado. A vista de esta obra maestra de la oratoria parlamentaria colombiana, el trabajo propone que la tradición escolástica de la Independencia neogranadina fue un factor determinante en la construcción de la identidad del Estado. Se concluye que esta Defensa sentó las bases retóricas en la configuración de la personalidad histórica de Colombia, una nación en trance.
La medicina clásica en la sanidad militar de la Campaña Libertadora de Nueva Granada 1819
Authors: Figueroa Pedreros Erika Constanza
Published: July 2019

Este artículo muestra cuáles fueron los fundamentos de la medicina hipocrática y galena del mundo clásico que convergieron en el contexto histórico de la sanidad militar en la Campaña Libertadora de la Nueva Granada de 1819. El aporte teórico corresponde específicamente a la caracterización del diagnóstico, el tratamiento y la relación entre el médico y el enfermo, evidenciados tanto en los escenarios de guerra como en los casos de enfermedad común. Por tanto, la pretensión del documento es identificar las fuentes clásicas de la medicina griega y romana en un hito histórico de gran importancia en el marco de la conmemoración del Bicentenario de la Batalla del Puente de Boyacá.
Pemetaan Jenis Pekerjaan Produksi pada Industri Busana Mitra Praktik Industri Mahasiswa Program Studi Tata Busana
Authors: Prahastuti Endang , Pradani Rizky Yulianingrum
Published: July 2019

Penelitian ini bertujuan untuk memetakan jenis pekerjaan produksi yang tersedia pada industri busana mitra Praktik Industri (PI) mahasiswa program studi tata busana. Rancangan penelitian yang digunakan adalah penelitian deskriptif kuantitatif. Populasi penelitian ini pemilik industri busana yang memiliki perjanjian kerjasama dengan pihak program studi sebagai tempat magang mahasiswa pada tahun 2017 sejumlah 21 industri busana tempat PI. Instrumen penelitian yang digunakan adalah angket tertutup dan wawancara tidak terstruktur. Instrumen diuji menggunakan teknik validitas konstruk.Teknik analisis data yang digunakan adalah analisis statistik deskriptif dengan persentase. Hasil penelitian menunjukkan bahwa: (1) 25% Industri Butik mengelola 17-24 jenis pekerjaan produksi, 75% mengelola 9-16 jenis pekerjaan produksi, (2) 66,6% Industri Modiste mengelola 17-24 jenis pekerjaan produksi, 22,2% mengelola 9-16 jenis pekerjaan produksi, 11,1% mengelola 1-8 jenis pekerjaan produksi,  dan (3) 50% Industri Garmen mengelola 9-16 jenis pekerjaan produksi, dan 50% mengelola 1-8 jenis pekerjaan produksi. Industri mitra mengelola jenis pekerjaan yang bervariasi sesuai dengan besar kecilnya quota pesanan, variasi kelengkapan jenis pekerjaan pada industri diperlukan untuk penyelaras ketidakseragaman kompentensi yang dikuasai mahasiswa.
Pengembangan Video Pembelajaran Mata Kuliah Teknologi Pengawetan Makanan Materi Kacang Disko
Authors: Anggraeni Andian Ari , Nugraheni Mutiara , Handayani Titin Hera Widi
Published: July 2019

Penelitian ini bertujuan  mengembangkan video pembelajaran yang layak pada mata kuliah Teknologi Pengawetan Makanan materi pembuatan kacang disko. Penelitian ini adalah penelitian pengembangan. Video dikembangkan dengan pendekatan 4D, yaitu define, design, develop dan disseminate. Pengumpulan data  menggunakan angket penilaian kelayakan media. Subyek penelitian 1 orang ahli materi, 1 orang ahli media dan 30 orang calon pengguna yaitu mahasiswa program studi Pendidikan Teknik Boga, Universitas Negeri Yogyakarta. Hasil penelitian menunjukkan bahwa video dikembangkan dengan format mp4,  durasi 11 menit. Video ini terdiri dari 5 bagian yaitu pembukaan, persiapan alat dan bahan, proses produksi, uji kadaluarsa dan penutupan. Dan menggunakan format presenter di bagian pembukaan dan penutupan. Bagian persiapan, produksi, dan uji kadaluarsa dipandu oleh suara dubber dan diperagakan oleh talent mahasiswa. Video diunggah dalam YouTube channel Pendidikan Teknik Boga Universitas Negeri Yogyakarta dengan URL https://youtu.be/ne7981MDqbY. Prosentase kelayakan video berdasar ahli materi 97%, ahli media 89% dan calon pengguna 79% yang semuanya masuk kategori sangat layak. Oleh karena itu, video kacang disko ini dinyatakan sangat layak untuk digunakan sebagai media pembelajaran pada mata kuliah Teknologi Pengawetan Makanan.
Analisis Tugas Akhir Skripsi Mahasiswa Pendidikan Teknik Busana
Authors: Widjiningsih Widjiningsih , Asiatun Kapti
Published: July 2019

Penelitian ini bertujuan mengetahui: (1). Pendekatan penelitian; (2). Populasi dan sampel; (3). Metode pengumpulan data; (4). Teknik analisis data; (5). Model pembelajaran; (6). Metode pembelajaran; (7). Bidang keahlian yang menjadi fokus penelitian; (8). Produk yang dihasilkan. Sampel  penelitian  adalah populasi  skripsi mahasiswa angkatan Tahun 2009/2010 sampai 2011/2012.  Analisis data yang digunakan analisis diskriptif. Hasil analisis konten: (1). Pendekatan penelitian adalah Reseach & Development sejumlah 43 skripsi  (37%), dan Penelitian Tindakan Kelas (PTK) sejumlah 34 skripsi (29,31%); (2).  Populasi penelitian tersebar di SD, SMP, SMK Tata Busana, dan masyarakat, sejumlah 116, terbanyak di SMK sejumlah 107 (92,24%).  (3).  Metode terbanyak yaitu  observasi  (89,65%); Uji  validitas  yang  banyak adalah   validitas  konstruk  (55,63%),  dan  validitas  isi  (37,755).  Reliabilitas  yang  digunakan adalah Alfa Cronbach (50,35%), dan Antar Rater (35,66% ); (4). Analisis data terbanyak menggunakan analisis deskriptif (61,21%); (5). Implementasi model pembelajaran yang terbanyak model Saintifik (22%);  (6). Metode pembelajaran banyak digunakan: Ceramah (29.2%),  Demonstrasi (25.8%),   Tanya  Jawab  dan  Penugasan  masing-masing  (17.5%);  (7). Bidang  keahlian  fokus penelitian terbanyak diteliti Pola Busana  (24,14%); (8) Produk terbanyak Job Sheet (29.77%).
Бронхіальна астма як патофізіологічний чинник формування саркопенії
Authors: Masik N.P. , Ponina S.I.
Published: July 2019

Актуальність. В умовах бронхіальної обструкції при бронхіальній астмі (БА) розвиваються зміни газового складу крові, оксидативний стрес, електролітний і метаболічний дисбаланси, що сприяють формуванню емфіземи легень і хронічної дихальної недостатності. При цьому виникають зміни дихальних м’язів, зокрема й у діафрагмі, що характеризуються прогресуючою їх атрофією з наступною втратою м’язової сили й маси. Мета: визначення функціональних можливостей скелетних м’язів і частоти розвитку саркопенії у хворих на БА. Матеріали та методи. Обстежено 70 осіб віком 47,82 ± 13,54 року. Першу групу становили 35 пацієнтів, які хворіють на БА, другу — 35 здорових осіб. Для оцінки функціональних можливостей скелетних м’язів застосовували 8-кроковий тест визначення швидкості ходьби. Силу скелетної мускулатури оцінювали за допомогою ручного пружинного динамометра. За величиною окружності гомілки оцінювали стан м’язової маси, якість життя вивчали за допомогою опитувальника О.С. Чабана. Результати. При оцінці сили скелетної мускулатури встановлено зменшення показників кистьової динамометрії на 22 % при тяжкому перебігу БА порівняно з показниками хворих на БА середньої тяжкості і на 29 % — порівняно із показниками здорових осіб. Встановлено кореляційні зворотні зв’язки між тяжкістю БА та силою кисті в жінок (r = –0,65) і чоловіків (r = –0,3); швидкістю ходьби у жінок (r = –0,72) та чоловіків (r = –0,6); окружністю гомілки у жінок (r = –0,17) і чоловіків (r = –0,28). Зниження сили м’язів і толерантності до фізичного навантаження асоціювалось із втратою м’язового компонента в 80 % пацієнтів з БА. Висновки. Саркопенія діагностована у 5,71 % осіб контрольної групи і у 25,71 % хворих на БА. Залежно від тяжкості БА і віку хворих саркопенію виявлено у 9,5 % пацієнтів із середньотяжкою БА і у 35,71 % — із тяжкою БА; у 10,53 % осіб віком молодших 45 років і у 31,25 % — старших 45 років.
Environmental awareness and participation of Filipino pre-service teachers
Authors: Lualhati Genalyn P.
Published: July 2019

Schools are accountable to cultivate environmental awareness and participation among future leaders. In an attempt to address this concern, this research determined the level of environmental awareness and involvement of teacher education seniors in one state university in the Philippines. Specifically, it focused on the respondents' level of environmental awareness in terms of issues and policies and level of environmental participation in terms of waste management, resource conservation, and environmental initiative. By employing the descriptive method of research with self-made questionnaire as its gathering tool. This paper found out that the respondents were unaware of environmental issues and policies, while they were moderately participative in activities relevant to environmental protection and conservation. With the findings of the study, enrichment activities offered by the researcher as well as considered by concerned authorities for its maximum actualization to enliven the once-perfect the environment which human beings continuously destroy.
Rational arrangement of direct plummets in concrete dams
Authors: Shainyan Georgy A.
Published: July 2019

Introduction. The design and construction of high hydroelectric installations are closely related to in-situ observations and studies over their condition and operation, which are the most reliable and effective means of verifying the reliability of calculation methods and design solutions. According to the results of the in-situ observations and studies during the construction and operation of dams, to monitor their condition by means of measurement systems, laboratory tests and calculation methods, unified methods can be developed for equipping the installations with devices on a unified principle. Currently, there is quite a lot of experience in the development and application of methods of in-situ research. New-type devices for measuring displacements, stresses in concrete, filtration flows and piezometric levels are developed. Automated systems for monitoring the behavior of hydraulic structures during the construction, filling of the reservoir and operation are installed. Modern satellite systems GLONASS and GPS are used.

Materials and methods. The research was carried out on the arch dam of Inguri HEPS by means of 2177 measuring systems, 46 of which are direct and opposite plummets. The body of the dam has three direct plummets and one in each of the rocky bank abutments. Displacements relative to the plummets were measured with an optical coordinate-measuring apparatus. Statistical analysis methods were used to process the measurement data.

Results. A technique of rational direct plummet arrangement in concrete dams was fine-tuned using statistical analysis methods and Barlow-Hunter-Proshan mathematical model based on the modern experience of in-situ observations and research. The type of distribution law of dam horizontal displacements was determined by means of analyzing the histograms of the measured indicators of the static state of the installation. The required number of plummets for the key console of the Inguri arch dam was specified. This technique was used in practice for designing high concrete dams.

Conclusions. Munlti-year experience in the research and operation of the Inguri HEPS arch dam allowed assessing the compliance of the mounted measuring systems with special control requirements and allocating the necessary amount of them for monitoring the strength and stability of the installation. The proposed methods of in-situ research data analysis based on the theory of probability, statistics and reliability were used in the design of the Hudoni HEPS dam.
FEATURES OF MANAGING PATIENTS AFTER THE FEMOROPOPLITEAL BYPASS
Authors: Kasianov B. V.
Published: July 2019

The approach to managing patients after femoropopliteal bypass surgery among vascular surgeons, even of one country, is sometimes not the same. The main difficulty is the problem of the late postoperative period patency of femoropopliteal bypasses (FPB). Aim. Analysis of the risk factors for occlusion of the FPB and the effects of postoperative diagnostic ultrasound on the primary, primary-assisted patency and secondary patency of such bypasses. Materials and methods. The Pubmed database was analyzed and the studies were selected from 2007 till 2017. The effect of preoperative risk factors on the FPB’s primary patency was evaluated in patients of the department of vascular surgery at the Orel regional hospital in comparison with the of foreign researchers’ data. The second stage was the evaluation of the effect of ultrasound diagnostic on the primary, primary-assisted and secondary patency of such bypasses. Results. The greatest impact on the primary patency of FPB was exerted by the presence of CLI, arterial hypertension and the male gender, and a slightly fewer by smoking and angina pectoris (χ2 cf. = -0.983-0.985*). The effect of diabetes was 2 times weaker (χ2 = -0.547*). Ultrasound control, in turn, had the greatest impact on the frequency of primary-assisted patency compared with the group without ultrasound control (81.3% vs. 76.1%). The frequencies of primary patency (67.4% vs. 64.9%) and secondary patency (83.2% vs. 82.8%) turned out to be almost comparable between the two groups of patients. Conclusions. Thus, the male sex, arterial hypertension and CLI are the most significant pre-operative risk factors affecting the primary patency of FPB. Regular diagnostic ultrasound in the postoperative period, especially in the period of 4-6 weeks, 3 months, 6 months and 1 year, allows to improve long-term results of such bypasses’ patency.
AGE AND GENDER PECULIARITIES OF CONSUMPTION OF MACROONUTRIENTS BY THE POPULATION OF THE RUSSIAN FEDERATION
Authors: Radzhabkadiev R. M. , Evstratova V. C. , Vybornaya K. V. , Khanferyan R. A.
Published: July 2019

The article contains the results of a survey of 11,850 persons of both sexes in eight Federal Districts of the Russian Federation. The survey was conducted on the following age groups of men and women: 12-17, 18-30, 31-45 and 46-60 years. In each group of subjects, the number of questionnaires was at least 150 persons of each sex. When comparing the consumption of macronutrients in different federal districts, it is established that there are insignificant age and gender differences in the level of their consumption. Studies have shown that the intake of proteins and carbohydrates is within the recommended consumption rates, and the fat component has been increased in the population of all federal districts of Russia.
Association of Personal Identity and Time Perspective in Patients with Alcohol Dependence: Cross-Cultural Research
Authors: Ignatev Pavel D. , Trusova Anna V.
Published: July 2019

The article presents the results of an original cross-cultural study of the identity and time perspective in alcohol-addicted patients. Based on the materials of the two examined patient groups from the Central (N = 79) and Arctic regions (N = 66) of Russia, using a set of the following psychodiagnostic methods - test of 20 statements by M. Kuhn, T. McPartland, Zimbardo Time Perspective Inventory (ZTPI), a semantic time differential and the questionnaire of motivation for alcohol consumption by V.Yu. Zavyalov (MAC) - the regional differences in the identity matrix and temporal orientations were found and described. According to the results of a clinical and psychological research, it was found that for alcohol-addicted patients in general the most significant is a reflexive identity focusing on “negative past”, while considering the past and future in the categories of “activity”, “affective sentiment”, “magnitude”. The leading alcohol use motives are hedonistic, ataractic, and activation behavior. At the same time, the communicative identity, “perceptibility” of the entire psychological time, as well as pseudocultural motive causing alcohol abuse are significantly present in the identity matrix of the patients from Saint Petersburg. In the group of patients from Yakutsk, there is a significant orientation toward a “fatalistic present”, with the “structurization” of the past, present, and future. The intergroup correlations between the various aspects of personal identity and time perspective, as well as the hierarchy of motives in patients with alcoholism in a socio-cultural context are shown. The correlation patterns between the identification characteristics and time perspective have significant differences in the two groups studied. The data obtained reflect the social specifics of the central regions, as well as the cultural characteristics of the northern nationalities with their inherent desire to avoid uncertainty. From these data, it can be concluded that the socio-psychological factors in the etiopathogenesis of alcohol dependence are significant.