bluuebunny/crossref_metadata_2025 huggingface dataset:
İŞÇİ SAĞLIĞI VE İŞ GÜVENLİĞİ (İSİG) SİSTEMİNİN İNŞAAT UYGULAMA İŞ PROGRAMINA ENTEGRASYONU
Authors: SEVIM MERVE , Gürcanlı Gürkan Emre
Published: December 2018

Ölümlü ve ağır yaralanmaların sık yaşandığı
inşaat sektöründe, iş kazaların önüne geçilmesi yönünde atılacak her adım hem can
kayıplarının önlenmesi açısından hem de işgücü ve maddi kayıpların ülke
ekonomisine etkisi açısından çok büyük bir öneme sahiptir. Yalnızca
ülkemizde değil, birçok ülkede iş kazaları ve iş güvenliği sorunlarının bir
türlü kontrol altına alınamamakta ve bu durum bu konunun ele alınması
zorunluluğunu daha da ön plana çıkarmaktadır.

Sektörde yer alan uygulamalara
bakıldığında, sahada en düşük kademede çalışan teknik personelden, yönetici
pozisyonunda çalışan kişilere kadar genel olarak İşçi Sağlığı ve İş Güvenliği
konusunda bilgi eksikliği görülmektedir. Şantiyelerde İSG kontrol ve denetim
mekanizmasının saha ekibinden ayrı olarak yönetilmesi,  İSG kontrol ve denetim ekibinin saha
imalatlarından ve iş programından habersiz olması İSG faaliyetlerinin de sahada
plansız olarak yürütülmesine ve dolayısıyla da problemlere ve iş kazalarına
sebep olmaktadır. İSG ekibi ve teknik ekip arasındaki koordinasyon eksikliği
entegre bir sisteme ihtiyacı doğurmaktadır. Bu problemin çözümüne ilişkin
gerçekleştirilen bu çalışmanın amacı, işçi sağlığı ve iş güvenliği  (İSİG) yönetim sistemi ile süresel planlama
sistemi arasındaki koordinasyon eksikliğinin giderilmesi amacı ile inşaat yapım
işleri iş programına entegre edilmiş bir işçi sağlığı ve iş güvenliği (İSİG)
bilgi belge sistemi yaratmaktır. ISO 45001 VE ISG iç tüzüğüne ilave olarak odak
grup çalışması yapılarak bir İSİG bilgi belge yönetim sistemi oluşturulmuştur Uygulama
projesine ilişkin iş programı Primavera programı P6 versiyonunda CPM tekniği
kullanılarak hazırlanmış ve ISIG yönetim sistemi içerisinde oluşturulan
aktiviteler, belgeler ve prosedürler; odak gruptaki iş güvenliği uzmanları
desteği ile uygulama inşaat iş programa entegre edilmiştir. Bu çalışma ile saha
ekipleri ile ISG kontrol denetim ekipleri arasındaki koordinasyon eksikliği
probleminin önüne geçilmesi hedeflenmektedir.
Is the typicality of “Provence Rosé wines” only a matter of color?
Authors: Coulon-Leroy Cécile , Pouzalgues Nathalie , Cayla Laure , Symoneaux Ronan , Masson Gilles
Published: December 2018

Aims: Given the diversity of French dry Rosé wines, Provence Rosé producers (France) wish to evaluate the typicality of their wines in order to better identify their typical characteristics. A clear pink color is one of them but they would also like to identify some specific odors and aromas. Here, we address these issues by: (i) assessing whether the identity of Provence Rosé wines is perceptible by tasting and shared by professionals based on specific odors and aromas (disregarding color as indicator using black glasses), and (ii) evaluating the impact of color on Provence Rosé wine typicality.Methods and results: Complementary methods were used: exemplarity measurements by a panel of wine professionals, sensory evaluation by a trained expert panel, and color assessment. It was confirmed that Provence Rosé wine typicality is based on color because the clearest wines were found to be more typical. However, typicality in odors and aromas was also demonstrated. Using black glasses, wine professionals from Provence agreed on ‘citrus fruit’, ‘exotic fruit’ and ‘fresh floral’ odors and aromas being typical attributes of Provence Rosé wines. Next, when using transparent glasses, the color of the wines clearly modified the perception of exemplarity.Conclusion: There is no single sensory profile of typical Provence Rosé wines. Variability within the sensory profiles of this specific Rosé wine area was observed, but some common aromatic and visual characteristics were identified.Significance and impact of the study: These results could be used as a marketing tool to better highlight the specific intrinsic characteristics of Provence Rosé wines. It will now be interesting to investigate the Provence area further in order to evaluate potential sub-area specificities linked to “terroir” factors.
Different application dosages of a specific inactivated dry yeast (SIDY): effect on the polysaccharides, phenolic and volatile contents and color of Sauvignon blanc wines
Authors: DEL BARRIO GALÁN Rubén , ÚBEDA Cristina , GIL Mariona , SIECZKOWKI Nathalie , PEÑA Álvaro
Published: December 2018

Aim: The aims of this study were to (i) study the effect of different application dosages of a commercial specific inactivated dry yeast (SIDY) on several compounds (polysaccharides, phenolic and volatile compounds) and attributes (color parameters) related to the quality of white wines, and (ii) acquire better knowledge about the use of different dosages of SIDY in white wines with the objective to improve their quality.Methods and results: Three different dosages were applied (10, 20 and 40 g hL-1). Treated wines were followed after a contact time period of two months and after a bottle aging period of three months. Total phenolic content, color intensity, CIELab coordinates, polysaccharides, low molecular weight phenolic compounds and volatile compounds were evaluated.Conclusions: Higher dosages of this SIDY resulted in a greater release of polysaccharides into the wine. In parallel, a positive effect on the reduction or prevention of wine oxidation was observed due to the interaction with certain phenolic compounds. The application of the highest dosage seems to lead to an adsorption or retention effect of the major identified volatile compounds. This effect seems to be more evident after the contact time period than after the bottle storage period.Significance and impact of the study: This study can contribute to improve our knowledge on how applying different dosages of SIDY affects the physical and chemical quality of white wines.
MONDROS’TAN LOZAN’A KADAR OLAN DÖNEMDE KIBRIS VE KIBRIS TÜRKLERİ - CYPRUS AND THE TURKISH CYPRIOTS FROM ARMISTICE OF MUDROS TO LAUSANNE PEACE TREATY
Authors: BALYEMEZ Mehmet , İNCE Fuat
Published: December 2018

Osmanlı İmparatorluğu, stratejik öneminden dolayı Kıbrıs’ı ele geçirme planlarını 1571 yılında gerçekleştirmiştir. Kıbrıs, bu tarihten itibaren 307 yıl boyunca Osmanlı egemenliğinde kalmıştır. Bu süre boyunca Kıbrıs’ta yaşayan etnik ve dinî bakımdan birbirinden farklı toplumlar barış içinde birlikte yaşamışlardır. Ta ki 19’uncu yüzyıla kadar.

Osmanlı Devleti, XIX. yüzyıldan itibaren çöküş sürecine girmiştir. Osmanlı Devleti’ndeki gayrimüslim toplumlar özellikle Fransız Devrimi’nin etkisinde kalmışlar ve tek tek bağımsızlık mücadelelerine başlamışlardır. Buna ilave olarak emperyalist devletler, Sanayi Devrimi’nin de bir sonucu olarak ortaya çıkan ham madde ihtiyacı ve sömürgelerindeki çıkarlarını korumak amacıyla Osmanlı toprakları üzerindeki planlarını hayata geçirmeye başlamışlardır.

Kıbrıs adası, XIX. yüzyıldaki gelişmelerden doğrudan etkilenmiştir. İngiltere, Osmanlı Devleti ile Rusya Çarlığı arasında yapılan savaş sonrasında Orta Doğu başta olmak üzere Doğu Akdeniz’deki çıkarlarının tehlikeye düştüğünü fark edince Kıbrıs’ı ele geçirme planlarını yürürlüğe koymuştur. Bu kapsamda olmak üzere 1878 yılında imzalanan antlaşma sonucu Kıbrıs’ın yönetimi geçici olarak İngiltere’ye terk edilmiştir. Kıbrıs’taki İngiliz egemenliği I. Dünya Savaşı başına kadar emanetçi olarak devam etmiştir. İngiltere, Osmanlı Devleti’nin Almanya safında savaşa katılmasını gerekçe göstererek 5 Kasım 1914’te adayı ilhak etmiş ve emanetçi konumunu kalıcıya çevirmiştir.

Kıbrıs Türk toplumu, gerek adanın İngiltere’ye geçici olarak devredilmesinden sonra ve gerekse de ilhak sonrasında Rumların Enosis girişimleriyle karşı karşıya kalmışlardır. Kıbrıslı Türkler, Rumların Enosis faaliyetlerine karşı en başından itibaren fazla tepki göstermemişlerdir. Kıbrıs Türk toplumunun tepkisiz kalmasının altında yatan sebep ise Osmanlı Devleti’nin er ya da geç Kıbrıs’ı geri alacağı yönündeki değerlendirmesi olmuştur. Ancak bu düşünce önce 1914 yılındaki İngiliz ilhakı daha sonra ise I. Dünya Savaşı sonunda imzalanan Mondros Ateşkes Antlaşması sonucu gelecek kaygısına dönüşmüştür.

Kıbrıs Türk toplumu, bu gelişmeler karşısında kendi geleceklerini kendileri belirleme kararı almışlardır. Birinci Dünya Savaşı’nı bitiren Mondros Ateşkes Antlaşması’ndan Lozan Barış Antlaşması’na kadar olan dönemde önemli girişimlerde bulunmuşlar ve kendi gelecekleriyle ilgili alınacak kararlarda belirleyici olmak istemişlerdir.
Exploring how Homophily and Accessibility can Facilitate Polarization in Social Networks
Authors: Taylor Cameron , Mantzaris Alexander V. , Garibay Ivan
Published: December 2018

Polarization in online social networks has gathered a significant amount of attention in the research community and in the public sphere due to stark disagreements with millions of participants in topics surrounding politics, climate, the economy and other areas where an agreement is required. There are multiple approaches to investigating the scenarios in which polarization occurs and given that polarization is not a new phenomenon but that its virality may be supported by the low cost and latency messaging offered by online social media platforms; an investigation into the intrinsic dynamics of online opinion evolution is presented for complete networks. Extending a model which utilizes the Binary Voter Model (BVM) to examine the effect of the degree of freedom for selecting contacts based upon homophily, simulations show that different opinions are reinforced for a period of time when users have a greater range of choice for association. The facility of discussion threads and groups formed upon common views further delays the rate in which a consensus can form between all members of the network. This can temporarily incubate members from interacting with those who can present an alternative opinion where a voter model would then proceed to produce a homogeneous opinion based upon pairwise interactions.
Connoisseur Consumers, Dynamics Capabilities and Sustainability of Indonesian Single Origin Coffee Consumption
Authors: Purnomo Mangku , daulay Pardamean , Riyanto Sugeng , Utomo Medea , Otten Fenna , Heiko Faust
Published: December 2018

Sustainable consumption became the community’s attention as the respond of worrying consumption growth direction that tends to excessively exploit nature without considering the continuity of the next generation. Take into account the growing coffee consumption in Indonesia, this article tries to prove whether the connoisseur consumers (CCs) are capable to mediate dynamics capabilities (DCs) of single origin coffee shops (SOCSs) and to encourage the consumption sustainability. In-depth interview to 30 SOCS managers, 60 baristas and 450 consumers, it is found that CCs are capable of supporting the business continuity of SOCSs because they are loyal consumers with the contribution of more than 20% from the total consumers. Correlation testing between connoisseurs’ attributes and the number of visits also shows positive value. It means there is a significant relationship. In addition, related to the sustainability attribute, the existence of CCs has encouraged the practice of consumption sustainability. At the same time, CCs are capable to moderate SOCSs to improve sensing, seizing, and transforming shop management to put up with the competition. Based on the above findings, CCs are moderating SOCSs in improving their DCs to be more potential in improving the sustainable consumption of coffee commodity in the future.
Silver Nanoparticle-Based Paper Packaging to combat Black Anther Disease in Orchid Flowers
Authors: Nokkrut Bang-on , Pisuttipiched Sawitree , Khantayanuwong Somwang , Puangsin Buapan
Published: December 2018

Metal nanoparticle has been reported to have a high antimicrobial activity against fungi, bacteria, and yeasts. In this study, silver nanoparticles (AgNPs) were synthesized using a chemical reduction method, at 90 oC, and used as an antifungal coating in paper packaging, to control the growth of C. gloeosporioides in cut orchid flowers during shipping. AgNPs were characterized by UV-Vis spectroscopy and atomic force microscope (AFM). The results indicated that the shape of AgNPs was spherical and homogenous with an average size of 47 nm. Twenty and 50 particles per million (ppm) concentration of AgNPs, mixed with starch, were prepared as the coating solution. The paper coated with 50 ppm AgNPs exhibited a significant antifungal activity against C. gloeosporioides compared to 20 ppm AgNPs coating. The AgNPs coated paper had a better water resistance and mechanical properties compared to paper without coating. We observed a significant reduction in the number of anthers, of orchid inflorescences, infected by C. gloeosporioides, when stored in the coated boxes. The current study demonstrates that paper boxes coated with AgNPs are a potential solution to control the infection of C. gloeosporioides in the storage of cut orchid flowers.
Integrated FISH, Karyotyping and aCGH analyses for Effective Prenatal Diagnosis of Common Aneuploidies and Other Cytogenomic Abnormalities
Authors: Chai Hongyan , DiAdamo Autumn , Grommisch Brittany , Boyle Jennifer , Amato Katherine , Wang Dongmei , Wen Jiadi , Li Peining
Published: December 2018

Current prenatal genetic evaluation showed a significantly increase in non-invasive screening and the reduction of invasive diagnostic procedures. To evaluate the diagnostic efficacy on detecting common aneuploidies, structural chromosomal rearrangements and pathogenic copy number variants (pCNV), we performed a retrospective analysis on a case series initially analyzed by aneuvysion fluorescence in situ hybridization (FISH) and karyotyping then followed by array comparative genomic hybridization (aCGH). Of the 386 cases retrieved from the past decade, common aneuploidies were detected in 137 cases (35.5%), other chromosomal structural rearrangements were detected in four cases (1%), and pCNV were detected in five cases (1.3%). The relative frequencies for common aneuploidies suggested a under detection of sex chromosome aneuploidies. Approximately 9.5% of cases with common aneuploidies showed a mosaic pattern. Inconsistent results between FISH and karyotyping were noted in cases with pseudo-mosaicism introduced by culture artifact or variable cellular proliferation from cells with mosaic karyotypic complements under in vitro cell culture. Based on findings from this case series, cell-based FISH and karyotyping should be performed to detect common aneuploidies, structural chromosomal abnormalities, and mosaic pattern. DNA-based aCGH and reflex FISH should be performed to detect and confirm genomic imbalances and pCNV. Practice points to ensure the diagnostic accuracy and efficacy were summarized.
Improving the Scientific Rigor of Nutritional Recommendations for Adults with Diabetes: A Comprehensive Review of the American Diabetes Association Guidelines Recommended Eating Patterns
Authors: Hallberg Sarah J. , Dockter Nancy E. , Kushner Jake , Athinarayanan Shaminie
Published: December 2018

Over half of adult Americans now have diabetes or prediabetes and worse, this epidemic is now world-wide and shows no signs of slowing, with rates of both diabetes and diabetes-related health complications still rising. When advising patients with diabetes on food choices, many providers rely on nutrition guidelines provided by the American Diabetes Association (ADA), and these guidelines influence other recommendations across the globe. Given the alarming trends in diabetes, it is paramount to review the treatment guidelines to ensure they are based on rigorous and accepted scientific methods. Our review included the evidence cited by the ADA in support of its claims and recommendations for eating patterns to combat diabetes (see Description of Eating Patterns, Supplemental Appendix), as presented in the most current edition of the annual ADA’s Standards of Medical Care in Diabetes (2018 Standards). Our review also includes sources cited in the latest edition of the ADA’s Nutrition Therapy Recommendations for Adults with Diabetes (2014 Recommendations),  which also informed the 2018 Standards.  In October 2018 low carbohydrate was named as a recommended eating pattern by the ADA and European Association for the Study of Diabetes (EASD)5but only citations from the 2014 and early 2018 ADA documents were reviewed.
Optimal Microbiome Networks: Macroecological Characterization and Criticality
Authors: Li Jie , Convertino Matteo
Published: December 2018

The human microbiome is extremely complex considering the amount of species, their interactions, and its variability over time as a function of environmental drivers. Here we untangle the complexity of the human microbiome for the Irritable Bowel Syndrome (IBS) that is the most prevalent functional gastrointestinal disorder linked to many causes. Based on a novel information theoretic network inference model (that considers conditional entropy reduction till the maximum entropy is not reduced further) we detect species interaction networks that are functionally and structurally different for healthy and unhealthy individuals. Healthy networks are characterized by a neutral symmetrical pattern of species interaction and small-world features for functional node degree and distance versus random unhealthy networks. We detect an inverse scaling relationship between species total outgoing information flow (''active flow'') and abundance. The top 10 interacting species are also the least abundant for the healthy microbiome and the most detrimental; however these species are controlled by other species (via negative feedbacks) and the microbiome is self-organized into a healthy state. On the contrary, the most abundant species for the unhealthy microbiome are the least interactive and the most detrimental. These findings support the idea about a diminishing role of network hubs and hubs should be defined considering total outgoing information flow. The healthy microbiome is characterized by high diversity growth rate, small species similarity decay over time (i.e. low species turnover), and small variability in the abundance of all species. This result challenges current views that posit an association between health states and the highest diversity in ecosystems rather than the highest biodiversity growth as in this study. In a network perspective the healthy microbiome is configured as a small-world network with a tendency toward a critical scale-free network while the unhealthy one is organized as a random network with many more interacting species. We show how the transitory microbiome at the edge of the healthy and unhealthy ones is unstable and criticality of the healthy microbiome is not at the phase transition (or second order) between order and chaos but in a meta-stable state (on the contrary of other critical systems where energy and entropy grow in the same direction and criticality is at the transition). We stress out the importance of considering interacting pairs versus single node dynamics when characterizing the microbiome nexus and of ranking these pairs in terms of their dynamics; interactions (i.e. species collective behavior) shape transition from healthy to unhealthy states. The macroecological characterization of the microbiome is useful for diagnostic purposes and disease etiognosis while species-specific analyses can detect species that are more beneficial to humans leading to personalized design of pre- and pro-biotic treatments and engineered microbiome transplants as two examples.
A Variety of Explicit Exact and Soliton Type Solutions of Conformable Fractional Equal-Width Equations
Authors: Korkmaz Alper , Zafar Asim , Rezazadeh Hadi
Published: December 2018

Exact and soliton type solutions have great importance in propagation of surface waves, fluid dynamics, optics, and many other elds of nonlinear sciences. In this study, the explicit and exact soliton type solutions for two space-time fractional Equal- Width (FEW) equations with conformable derivative are procured via the hyperbolic function approach. The wave type solutions are represented in some hyperbolic and trigonometric functions.
Characterization of Polyurethane Foam Waste for Reuse in Eco-Efficient Building Materials
Authors: Gómez Rojo Raúl , Alameda Lourdes , Rodríguez Ángel , Calderón Verónica , Gutiérrez González Sara
Published: December 2018

In the European Union, the demand for polyurethane is continually growing. In 2017, the estimated production value of polyurethane was 700,400T, of which 27.3% is taken to landfill, which causes an environmental problem. In this paper the behaviour of various polyurethane foams from the waste of different types of industries will be analysed with the aim of assessing their potential use in construction materials. In order to this, the wastes were chemically tested by means of CHNS, TGA, and leaching tests. They were tested microstructurally by means of SEM. The processing parameters of the waste was calculated after finding out its granulometry and its physical properties i.e. density and water absorption capacity. In addition, the possibility of incorporating these wastes in plaster matrices was studied by determining its rendering in an operational context, finding out its mechanical resistance to flexion and compression at 7 days, its reaction to fire as well as its weight per unit of area and its thermal behaviour. The results show that in all cases, the waste is inert and does not undergo leaching. The generation process of the waste determines the foam’s microstructure in addition to its physical-chemical properties that directly affect building materials in which they are included, thus offering different ways in which they can be applied.
Tracking the Healing Process of Experimental Liver Injuries Treated with Different Sealants and Adhesive Biomaterials: An Evaluation of Matrix Metalloproteinase
Authors: Lloris-Carsí José Miguel , Barrios-Pitarque Carlos , Lloris-Cejalvo José Miguel , Gil-Santos Luis , Cejalvo-Lapeña Dolores
Published: December 2018

This study examines the matrix metalloproteinase (MMP) activity in the healing of liver injuries treated with biological adhesives Tachosil® and GelitaSpon® and the elastic cyanoacrylate Adhflex®. Hepatic lesions were induced in male rats using a Stiefel biopsy punch. Healing was assessed 2, 6, and 18 days after injury by quantifying tissue levels of MMP1, 2, 8, 9, and 13. Histopathological repair was evaluated using hematoxylin-eosin, Masson’s trichrome, and Periodic Acid Schiff (PAS) staining and immunohistochemical markers CD31 and CD68. The sealants contributed to complete healing. Histopathology and MMP findings indicate that Adhflex® has slower degradation and a strong inflammatory reaction at the onset of healing. Early on, all MMPs showed higher levels in Adhflex® and Tachosil®-treated animals, and MMP2 and MMP9 expressions were significantly higher in the Adhflex-treated group at 18 days post-injury (T3). The Adhflex® group had significantly higher MMP8 and MPP13 levels than other treated groups and showed a sustained overexpression of all MMPs, even in the latest healing stages. Notably, the overexpression did not negatively influence the histological healing process. All hepatic trauma injuries should be treated as emergencies, and any easy-to-use and rapid sealant like Adhflex® could be considered as an option for treating liver trauma.
Modeling of Disordered Protein Structures Using Monte Carlo Simulations and Knowledge-Based Statistical Force Fields
Authors: Ciemny Maciej Pawel , Badaczewska-Dawid Aleksandra Elzbieta , Pikuzinska Monika , Kolinski Andrzej , Kmiecik Sebastian
Published: December 2018

The description of protein disordered states is important for understanding protein folding mechanisms and their functions. In this short review, we briefly describe a simulation approach to modeling disordered protein interactions and unfolded states of globular proteins. It is based on the CABS coarse-grained protein model that uses a Monte Carlo (MC) sampling scheme and a knowledge-based statistical force field. We review several case studies showing that description of protein disordered states resulting from CABS simulations is consistent with experimental data. The case studies comprise investigations of protein-peptide binding and protein folding processes. The CABS model has been recently made available as the simulation engine of multiscale modeling tools enabling studies of protein-peptide docking and protein flexibility. Those tools offer customization of the modeling process, driving the conformational search using distance restraints, reconstruction of selected models to all-atom resolution and studies of large protein systems in a reasonable computational time. Therefore, CABS can be combined in integrative modeling pipelines incorporating experimental data and other modeling tools of various resolution.
Theoretical Studies on the Creation of Artificial Magnetic Monopoles
Authors: Ishiguri Shinichi
Published: December 2018

In this study, we discuss the theoretical studies on the creation of artificial magnetic monopole, and new electromagnetic equations. Employing Lorentz transformation, radial electrostatic fields, and a stationary wave derived from a superconducting loop, we demonstrate the existence of a magnetic monopole whereby the divergence of the magnetic field is not zero. We develop a device wherein a condenser provides electrostatic fields along the radial direction to the superconducting loop and discuss the nodes of the resulting stationary wave along the superconducting loop. We employ the Lorentz transformation with respect to the vector and electrostatic potentials. Then, because the nodes have no three-dimensional vector potential and have zero magnetic field rotation, the conserved energy is converted into new form that is associated with the magnetic field potential to yield the Lorentz transformation. As a result, we derived the relationship between the electric and the magnetic fields. This dependent relationship involves the exchange of the distribution characteristics of the static electric and static magnetic fields, and new electromagnetic equations of both electric and magnetic fields are obtained. We also analyzed the magnetic field from the magnetic monopole whose result assists the theory.
Development of Aluminum Honeycomb Cored Carbon Fiber Reinforced Polymer Composite Based Sandwich Structure
Authors: Okur Mehmet Ziya , Kangal Serkan , Tanoğlu Metin
Published: December 2018

Lightweight composite sandwich structures are laminated composite structures that are composed of thin stiff face sheets bonded to a thicker lightweight core in between. These structures have high potential to be used in marine, aerospace, defense and civil engineering applications due to their high strength to weight ratios and energy absorption capacity.In this study, composite sandwich structures were developed with carbon fiber reinforced polymer composite face sheets and aluminum honeycomb core materials with various thicknesses. Carbon fiber/epoxy composite face sheets were fabricated with lamination of [0/90]s carbon fabrics by vacuum infusion technique. Al honeycomb layers were sandwiched together with the face sheets using a thermosetting adhesive. Mechanical tests were carried out to determine the mechanical behavior of face sheets, Al cores and the composite structure. Effect of core thickness on the mechanical properties of the sandwich was investigated.
The Future of European Onshore Wind Energy Potential: Detailed Distribution and Simulation of Advanced Turbine Designs
Authors: Ryberg David Severin , Caglayan Dilara Gulcin , Schmitt Sabrina , Linßen Jochen , Stolten Detlef , Robinius Martin
Published: December 2018

Considering the need to reduce greenhouse gas emissions, onshore wind energy is certain to play a major role in future energy systems. This topic has received significant attention from the research community, producing many estimations of Europe's onshore wind potential for capacity and generation. Despite this focus, previous estimates have relied on distribution assumptions and simulation schemes that summarily under predict both the amount of available future wind capacity as well as its performance. Foremost in this regard is the common use of contemporary, or at least near-future, turbine designs which are not fitting for a far-future context. To fulfill this role, an improved, transparent, and fully reproducible work flow is presented for determining European onshore wind potential. Within a scenario of turbine cost and design in 2050, 13.5 TWof capacity is found to be available, allowing for 34.4 PWh of generation. By sorting the explicitly-placed potential generation locations by their expected generation cost, national relations between turbine cost and performance versus a desired capacity are exposed. In this way, it is shown that all countries possess some potential for onshore wind energy generation below 4 €ct kWh-1. and, furthermore, that it is unlikely for these costs to exceed 6 €ct kWh-1.
Reduction of Anisotropic Volume Expansion and the Optimization of
Specific Charge Capacity in Lithiated Silicon Nanowires
Authors: Boone Donald
Published: December 2018

Abstract: This computational research study analyzes the increase of the specific charge capacity that comes with the reduction of the anisotropic volume expansion during lithium ion insertion within silicon nanowires. This research paper is a continuation from previous work that studied the expansion rate and volume increase. It has been determined that when the lithium ion concentration is decreased by regulating the amount of Li ion flux, the lithium ions to silicon atoms ratio, represented x, decreases within the amorphous lithiated silicon (a-LixSi) material. This results in a decrease in the volumetric strain of the lithiated silicon nanowire as well as a reduction in Maxwell stress that was calculated and Young’s elastic module that was measured experimentally using nanoindentation. The conclusion as will be seen is that as there is a decrease in lithium ion concentration there is a corresponding decrease in anisotropic volume and a resulting increase in specific charge capacity. In fact the amplification of the electromagnetic field due to the electron flux that created detrimental effects for a fully lithiated silicon nanowire at x=3.75 which resulted in over a 300% volume expansion becomes beneficial with the decrease in lithium ion flux as x approaches 0.75 which leads to a marginal volume increase of ~25 percent. This could lead to the use of crystalline silicon, c-Si, as an anode material that has been demonstrated in many previous research work to be ten times greater charge capacity than carbon base anode material for lithium ion batteries.
Deregulation of VEGFR-2 and PGFR Expression and Microvascular Density in a Triple-Negative Model of Canine Malignant Mammary Tumors with Lymph Node or Lung Metastasis
Authors: Anjos Denner Santos , Vital Aline Fernandes , Lainetti Patricia de Faria , Leis-Filho Antonio Fernando , Dalmolin Fabiola , Elias Fabiana , Calazans Sabryna Gouveia , Fonseca-Alves Carlos Eduardo
Published: December 2018

Canine mammary tumors (CMT) are the most common cancer in noncastrated female dogs. Interestingly, triple-negative tumors are the most common molecular subtype in female dogs. In this study, we proposed to evaluate the expression of VEGFR-2, PDGFR and microvascular density (MVD) in a group of metastatic and nonmetastatic triple-negative CMT and compare the expression based on clinical parameters. Twenty-six female dogs with triple-negative mammary tumors were divided into three groups: nonmetastatic tumors (NMT) (N=11), tumors with lymph node metastasis (LNM) (N=10) and tumors with lung metastasis (LM) (N=5). We observed increased VEGFR-2 expression in LNM compared with NMT and a positive correlation between tumor grade and VEGFR-2 expression. A positive correlation was noted between VEGFR-2 and PDGFR expression. Regarding microvascular density (MVD), we identified a higher number of vessels in primary tumors with lymph node metastasis and lung metastasis compared with tumors with no metastasis. The primary tumors with lung metastasis exhibited an increased MVD compared with carcinoma with lymph node metastasis. Overall, our results suggest a deregulation of VEGFR-2 and PDGFR and high MVD in metastatic tumors, indicating a role for angiogenesis in tumor progression.
MicroRNA cross-involvement in Autism Spectrum Disorders and Atopic Dermatitis: a literature review
Authors: Tonacci Alessandro , Bagnato Gianluca , Pandolfo Gianluca , Billeci Lucia , Sansone Francesco , Conte Raffaele , Gangemi Sebastiano
Published: December 2018

Autism Spectrum Disorders (ASD) are neurodevelopmental disturbances affecting social skills, whose incidence worldwide is dramatically increasing. Together with the rise of ASD prevalence, several immune conditions are following the same trend, including Atopic Dermatitis (AD), with a possible clinical relationship with ASD. To date, their pathogenesis is still unknown, but several studies highlighted the relevance of gene-environment interactions to the onset of both disorders. Among potential contributing factors, microRNAs (miRNAs), small molecules capable of controlling gene expression and targeting mRNA transcripts, might represent one of the major circulating link, unraveling the connections between neurodevelopmental and immune conditions.
We conducted a systematic literature review, under the PRISMA guidelines, trying to define the panel of common miRNAs involved in both ASD and AD. The review retrieved articles published until December 13, 2018, in PubMed, ScienceDirect, PsycARTICLES and Google Scholar.
We found a handful works dealing with miRNAs in ASD and AD, with the most overlapping dysregulated miRNAs being miR-146 and miR-155.
Two possible compounds are abnormally regulated in both ASD and AD subjects, possibly cross-contributing to the interactions between the two disorders, setting the basis to investigate more precisely the possible link between ASD and AD from another, not just clinical, perspective.
Bayesian VAR Modeling and Forecasting of the Dynamic Interrelationship between Economic Growth and Revenue from Oil and Non-Oil Sectors in Nigeria
Authors: Adenomon Monday Osagie
Published: December 2018

The present reality about the Nigerian economy calls for investment and development in the non-oil sector. This becomes necessary as a result of fall in the oil price in the global market. This paper examined the Bayesian Vector Autoregression (BVAR) modeling and forecasting of the dynamic interrelationship between Economic growth and revenue from the oil and non-oil sectors in Nigeria. To achieve this, annual data on Gross Domestic Product (GDP), revenue from oil and non-oil sectors were collected from Central Bank of Nigeria (CBN) bulletin, the sample from 1981 to 2008 was used for analysis, while sample from 2009 to 2014 was used for model validation. Six (6) versions of Sims-Zha BVAR models were compared for out-of-sample forecast, the result revealed the superiority of the BVAR6 model over the other BVAR models. Lastly, evidence from the decomposition forecast errors revealed that revenue of oil sector contributed 7.69% to GDP while revenue from non-oil sector contributed 0.12% to GDP in Nigeria. This paper therefore recommended that the present government should encourage investment that is geared toward development in the non-oil sector, of which it has the capacity to improve the Economic growth of the Nigerian economy.
Fish Protein and Lipid Interactions on the Digestibility and Bioavailability of Starch and Protein from Durum Wheat Pasta
Authors: Desai Ajay , Brennan Margaret , Guo Xinbo , Zeng Xin-An , Brennan Charles
Published: December 2018

This research focussed on utilisation of salmon protein and lipid to manipulate pasta glycaemic index and protein digestibility. Salmon fish (Oncorhynchus tschawytscha) powder (SFP) supplemented pasta flour at the from 5% to 20% (w/w). Inclusion of SFP lead to a significant reduction in starch digestibility and hence the potential glycaemic values of pasta (experimental pasta being up to 143% lower than control values). SFP addition to pasta increased the release of phenolic compounds from pasta during both a gastric digestion (179%) and pancreatic digestion ( 133%) in comparison to the control sample. At the same time, the antioxidant activity of the digested pasta was increased by up to 263% (gastric) and 190% (pancreatic) in comparison to durum wheat pasta alone. Interestingly, although protein levels increased with incorporation of SFP, the digestibility values of the protein decreased from 86.41% for the control pasta to 81.95% for 20% SFP pasta. This may indicate that there are interactions between phenolic and protein in the pasta samples which affect overall protein digestibility levels.
Dynamic Evolution Hypothesis of Organisms
Authors: Wu Yonghua
Published: December 2018

I propose a dynamic evolution hypothesis regarding the evolution of organisms by incorporating both diminished fitness returns and mutation rate tuning during adaptation to a constant environment. Basically, accumulating evidence from life history studies conducted over the past 70 years suggests that the evolution of individual fitness is subject to ecological constraints, leading to the evolutionary existence of an upper limit of individual fitness (ULIF). Given the existence of the ULIF, organismal evolution, which might initially have relatively great fitness returns through primarily Darwinian evolution, will eventually be subject to diminished fitness returns towards zero. With the diminished fitness return, Darwinian selection strength may eventually become smaller than the power of random genetic drift, leading to the occurrence of neutral evolution at both phenotypic and molecular levels. Meanwhile, mutation rates may change from an initial increase, due to the relatively strong fitness return, to subsequent decreases, due to both the diminished fitness return of beneficial mutations and the cost of deleterious mutations. The diminished fitness returns with subsequently reduced mutation rates are two potential evolution barriers leading to eventual evolutionary stasis. These findings provide important insights for understanding the conditions for the occurrences of different evolutionary patterns. Darwinian evolution theory, neutral evolution theory and punctuated equilibrium theory can be unified in the context of the dynamic evolution hypothesis formulated in this study.
Classical and Quantum Kepler's Third Law of N-Body System
Authors: Sun Bohua
Published: December 2018

Inspired by amazing result obtained by Semay [1], this study revisits generalised Kepler's third law of an n-body system from the perspective of dimension analysis. To be compatible with Semay's quantum n-body result, this letter reports a conjecture which not be included in author's early publication [2] but formulated in the author's research memo.
Modular Rotor Single Phase Field Excited Flux Switching Machine with Non-Overlapped Windings
Authors: Ur Rahman Lutf , Khan Faisal , Fatima Areej , Khan Muhammad Afzal , Ahmad Naseer , Shahzad Mohsin , Khan Hamid Ali , Ali Hazrat
Published: December 2018

In recent years, numerous topologies of single phase and three phase Field Excited Flux-Switching Machine (FEFSM) have been developed for several applications. Comparative study of three types of single-phase low-priced Field Excited Flux-Switching Machine (FEFSM) is presented in this paper. Both the conventional 8S/4P sub-part rotor design and 6S/3P salient rotor design have an overlapped winding arrangements between armature coil and field excitation coil that depicts high copper losses as well as  results in increased size of motor. Additionally, FEFSM with salient structure of the rotor have high flux strength in the stator-core that has much impact on high iron losses. Copper consumption and iron loss being a crucial proportion in total machine losses. Therefore a  novel topology of single phase modular rotor field excited FSM with 8S/6P configuration is proposed, which enable non-overlap arrangement between armature coil and FEC winding that facilitates devaluation in the copper losses. The proposed modular rotor design acquires reduced iron losses as well as reduced active rotor mass comparatively to conventional rotor design. It is very persuasive to analyze the best range of speed for these rotors to avoid cracks and deformation, the maximum tensile strength (can be measured with principal stress in research) of the rotor analysis is conducted using JMAG. A deterministic optimization technique is used to enhance the performance of 8S/6P modular rotor design. The electromagnetic performance of conventional sub-part rotor design, F1-A3-3P design and proposed novel-modular rotor design are analyzed by 3D-Finite Element Analysis (3D-FEA), includes flux linkage, flux distribution, flux strength, back-EMF, cogging torque, torque characteristics, iron losses and efficiency.
Neural Population Coding and Approximations of Mutual Information for Discrete Variables
Authors: Huang Wentao , Zhang Kechen
Published: December 2018

Information theory is widely used in various disciplines, and effective calculation of Shannon mutual information is typically not an easy task for many practical applications, including problems of neural population coding in computational and theoretical neuroscience. Asymptotic formulas based on Fisher information may provide accurate approximations to mutual information but this approach is restricted to continuous variables because the calculation requires derivatives with respect to the encoded variables. In this paper, we consider information-theoretic bounds and approximations based on Kullback-Leibler divergence and Rényi divergence. We propose several information metrics to approximate Shannon mutual information in the context of neural population coding, and these asymptotic formulas hold true for discrete variables as there is no requirement for differentiability. In particular, one of our approximation formulas has consistent performance and good accuracy regardless of whether the encoded variables are discrete or continuous. We performed numerical simulations and confirmed that our approximation formulas were highly accurate for approximating mutual information between the discrete variables or stimuli and the responses of a large neural population. These approximation formulas may potentially bring convenience to the applications of information theory to many practical and theoretical problems.
Common Connectivity Phenotypes in Rapid Eye Movement Sleep Behavior Disorder and Parkinson’s Disease: The Search for an Intermediate Phenotype
Authors: Moodie Craig A. , Lim Kelvin O. , Mueller Bryon A. , Hemmy Laura S. , Howell Michael J. , Tuite Paul J.
Published: December 2018

Rapid eye movement sleep behavior disorder (RBD) is often prodromal to Parkinson’s disease (PD).  Thus there should be detectable in vivo functional signatures shared between RBD and PD that aid in disease classification. To assess common in-vivo phenotypes, resting state data was collected on a 3T clinical MRI platform and a novel functional connectivity magnetic resonance imaging (fcMRI) approach, which combined independent component analysis (ICA) and graph theory, was used to evaluate deficits in interconnectivity among 15 PD, 14 RBD and 13 control participants. Whole brain and network-level analyses revealed the largest deficits in network connectivity in PD compared with controls, with less severe differences between RBD and controls. Importantly, the network-level analysis demonstrated decreased network interconnectivity, with the greatest aberrant networks in PD, and a subset in RBD.  Additionally, a disease classification algorithm predicted PD cases by being trained on RBD cases with 0.87 sensitivity and 0.68 specificity. The functional alterations in cortical networks in RBD extended beyond the brainstem. These findings demonstrate progressive reductions in connectivity between brain networks, with less severe deficits in RBD than PD. Moreover, RBD phenotypes can be used to predict PD status in a cross-sectional sample, which suggests RBD is an intermediate phenotype.
Semantic Segmentation of Building Roof in Dense and Diverse Urban Environment with Deep Convolutional Neural Network
Authors: Qin Yuchu , Wu Yunchao , Li Bin , Gao Shuai , Liu Miao , Zhan Yulin
Published: December 2018

This paper presents a novel approach for semantic segmentation of building roof in dense urban environment with Deep Convolution Neural Network (DCNN) using imagery acquired by a Chinese Very High Resolution (VHR) satellite mission, i.e. GaoFen-2 (GF-2). To provide an operational end-to-end work flow for accurate build roof mapping with feature extraction as well as image segmentation, a fully convolutional DCNN with both convolutional and deconvolutional layers is designed to perform the VHR image analysis for labeling pixels. Since the diverse urban patterns and building styles in large areas, sample image data sets of building roof and non-building roof are collected over different metropolitan regions in China. We selected typical cities with dense urban environment in each metropolitan region as study areas for collecting training and test samples. High performance cluster with GPU-mounted workstations is employed to perform the model training and optimization. With the building roof samples collected over different cities, the predictive model with multiple NN layers is developed for building roof labeling. The validation of the building roof map shows that the overall accuracy(OA) and the mean Intersection Over Union( mIOU) of DCNN based segmentation are 94.67%, 0.85 respectively, while CRF-refined segmentation achieved OA of 94.69% and mIOU of 0.83. The results suggest that the proposed approach is a promising solution for building roof mapping with VHR images over large areas across different urban and building patterns. With the operational acquisition of GF2 VHR imagery, it is expected to develop an automated pipeline for operational built-up area monitoring and timely update of building roof map over large areas.