bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effects of Bracing on Pelvic Parameters in Adolescent Idiopathic Scoliosis
Authors: Li Kepeng , Miao Jun , Zhang Jingan , Wang Xijie , Han Ye
Published: February 2021

Background: This study aims to evaluate the effects of bracing on the Cobb’s angle (CA) and spinopelvic parameters in adolescent idiopathic scoliosis (AIS) patients. Methods: A total of 51 AIS patients who received bracing treatment between January 2018 and August 2019 were retrospectively analyzed. The pro-bracing and in-bracing radiographs were analyzed with regard to the spinopelvic parameters. The CA, pelvic coronal obliquity angle (PCOA), thoracolumbar kyphosis (TK), lumbar lordosis (LL), pelvic incidence (PI), pelvic tilt (PT), sacral slope (SS), sagittal vertical angle (SVA) and coronal vertical angle (CVA) were measured. Results: The mean age at the initiation of bracing was 13.6 ± 1.5 years. The mean pro-bracing CA was 24.0° ± 6.3°. There were no statistically significant differences between pro-bracing and in-bracing measurements of SVA and CVA. However, there were statistically significant differences between the pro-bracing and in-bracing measurements of the CA, PCOA, TLK, LL, PT and SS. A significant correlation was observed between PT variation and TLK variation in the sagittal plane. In the coronal plane, the PCOA variation was correlated to pro-bracing PCOA. Conclusion: Bracing effects of AIS can be extended to the pelvis. The pelvis should retro-rotate correspondingly to TLK hypokyphosis on sagittal plane, whereas in coronal plane, pelvic obliquity was improved independently.
Influence of Comorbidities on Functional Outcomes in Patients With Surgically Treated Fragility Hip Fractures: a Retrospective Cohort Study
Authors: Yoon Soo Hoon , Kim Bo Ryun , Lee Sang Yoon , Beom Jaewon , Choi Jun Hwan , Lim Jae-Young
Published: February 2021

Background: The incidence and number of fragility hip fractures are gradually increasing, resulting in a wide consumption of medical resources. Various factors affecting functional recovery in patients with fragility hip fractures are known, and comorbid diseases are one of them. The purpose of this study is to determine the effect of comorbidities on functional outcomes in patients surgically treated for fragility hip fractures, thereby contributing to the efficient distribution of medical resources.Methods: This was a retrospective cohort study performed in the three tertiary rehabilitation facilities. A total of 211 patients (50 men and 161 women; average age 81.6±6.7 years) who had undergone surgery for fragility hip fractures were followed up from immediately after transfer to the Department of Rehabilitation Medicine to 6 months postoperatively. Comorbidities referred to a summary of the following conditions: hypertension, diabetes mellitus, chronic liver disease, dementia, cerebrovascular accident, and osteoporosis. Functional outcomes included Koval’s grade, functional ambulatory category (FAC), functional independence measure (FIM)-locomotion, modified Rivermead mobility index, Berg balance scale (BBS), 4-meter walking speed test, the Korean version of the Mini-Mental State Examination, Geriatric Depression Scale (GDS), EuroQol five-dimension (EQ-5D) questionnaire, the Korean version of the Modified Barthel Index, the Korean version of the instrumental activities of daily living (K-IADL), and Korean version of fatigue, resistance, ambulation, illnesses, and loss of weight scale (K-FRAIL). For all tests, each patient was assessed immediately after transfer and 6 months post-surgery.Results: Multivariate linear regression analyses adjusted for age, sex, the initial variable of the functional outcomes, and comorbidities revealed that dementia had a significant negative impact on Koval’s grade and K-FRAIL 6 months postoperatively. Diabetes mellitus had a significant negative impact on the FAC, GDS, EQ-5D, K-IADL, and K-FRAIL 6 months postoperatively. Patients with osteoporosis showed a significant negative outcome of FIM-locomotion 6 months postoperatively. A cerebrovascular accident revealed a significant negative impact on the BBS 6 months postoperatively. In addition, hypertension led to significantly less favorable outcomes of the K-FRAIL 6 months postoperatively. Conclusions: This study confirmed that comorbidities, particularly dementia and diabetes mellitus, significantly influence functional outcomes 6 months after fragility hip fracture surgeries.
Physiological uterine uptake of 68Ga-FAPI-04 may limit its application in uterine pathology
Authors: Zhang Xiao , Song Wenyu , Qin Chunxia , Song Yangmeihui , Liu Fang , Hu Fan , Lan Xiaoli
Published: February 2021

Purpose68Ga-labeled fibroblast activation protein inhibitor (68Ga-FAPI) has been useful in the imaging of desmoplastic reaction in different tumors, as well as fibrosis in inflammatory diseases. As we have found that most female patients showed avid uterine uptake of 68Ga-FAPI, we sought to further investigate the physiological uptake of 68Ga-FAPI by the uterus and analyze its characteristics in women of childbearing age, in perimenopause, and postmenopause.MethodsWe retrospectively reviewed the image data of female patients who had undergone whole-body 68Ga-FAPI-04 PET/MRI at our institute between May 22 and December 16, 2020. The clinical information of the patients, including age, stage of menstrual cycle if present, and gynecologic history, was collected. Uterine volume was calculated from MR images. The characteristics of 68Ga-FAPI-04 uterine uptake were recorded. If the patients also had undergone 18F-FDG PET/CT imaging, those image features were also recorded. The relationship of age, uterine size, surgical history, presence of leiomyomas, and 18F-FDG uptake to 68Ga-FAPI-04 uptake were further analyzed.ResultsForty-three female patients were included in this study. The number of cases with uterine malignancy and non-malignancy were two and 41, respectively. Twenty-seven patients in the benign disease group underwent simultaneous 18F-FDG PET/CT scans. Of 41 patients with benign uterine pathology, 13 patients were of reproductive age, six were perimenopausal, and 22 were postmenopausal. A total of 25 patients had undergone invasive operations, and six patients had uterine fibroids under examination. Lower 68Ga-FAPI-04 uptake (6.58 ± 3.39, n = 22) was noted in postmenopausal women than in reproductive and perimenopausal females (13.32 ± 3.2 and 12.98 ± 3.01, respectively, P < 0.05). The invasive operation or accompany with uterine fibroids may increase 68Ga-FAPI-04 uptake. 68Ga-FAPI-04 uptake was also associated with uterine volume (P < 0.01). There was no correlation between 18F-FDG and 68Ga-FAPI-04 accumulation in the uterus. Two patients with malignant lesions involving the uterus showed completely different imaging features on 68Ga-FAPI-04.ConclusionPhysiological uterine uptake of 68Ga-FAPI-04 limits its diagnostic value in gynecologic diseases. Age, uterine fibroids and uterine volume may influence the uptake of 68Ga-FAPI-04 in uterus. More patients with various uterine diseases could be involved to provide more differential diagnostic information.Clinical Trial RegistrationNCT04605939 and NCT04554719.
Antiparasitic potential of alternative treatments against larval stages of Lernaea cyrpiancea
Authors: Furtado William Eduardo , Cardoso Lucas , Medeiros Paula Brando de , Lehmann Nicollas Breda , Bertaglia Elisabeth de Aguiar , Marchiori Natalia da Costa , Bertoldi Fabiano Cleber , Martins Maurício Laterça
Published: February 2021

This study evaluated the potential of alternative treatments against larval stages of Lernaea cypriancea. For in vitro test, the nanoemulsified oils of Pinus sp. acicule and resin were evaluated, along with Biogermex® (commercial product based on citrus biomass). For this, the motility of five larvae of the same stage (nauplii or copepodite) were evaluated in a 96-well microplate. Using the best results, on the in vivo test, fries of Rhamdia quelen were submitted to a long-term immersion bath (96 h) containing different concentrations of the product diluted directly in the water. It was possible to notice the antiparasitic potential of the resin and the acicule of Pinus sp., as well as the citrus biomass extract against the parasites. The nanoemulsified oils successfully inhibited the development of nauplii (10 mg L− 1 in 24 h) and the fries showed to be tolerant to the presence of the compound (LC50 96h − 16.74 mg L− 1). The concentration of 30.5 mg L− 1 of Biogermex® eliminated the copepodites within 24 h, being more efficient than Pinus sp. when tested at the same stage, at the times analyzed. The results obtained indicate a potential use of these compounds as prophylactic agents against L. cyprinacea.
Urban Forest Inventory For Carbon Reduction In A University City Campus
Authors: Yusoff Safiah Yusmah Muhammad , D Melasutra Md , Hassan Norhaslina
Published: February 2021

Background

Performing forest inventory in the campus is one of the breakthroughs towards achieving sustainable campus. The inventory aims to determine the number of trees and calculate the stocking of carbon and biomass. This is inevitably important when the contribution of trees to the oxygen supplies as well as stocks for carbon biomass are of concern. Realising the importance of contribution of trees to the surrounding community, this study was therefore conducted.
Results

The study area is identified as secondary type forest with 50.1% of the strata is 60–80% canopy cover dominated by small stands. There is a total of 14 sampling plots inventoried and measured using 40 x 40m square plot sampling. 41% of the three species found comprised of rubber trees (Hevea Brasiliensis). The total number of trees estimated is 97,325 trees with the average density of 21 m2/ha and 24,146.54 Mg CO2e aboveground biomass and carbon stocking.
Conclusion

The study has successfully assessed the forest resources that are available in University Malaya campus. It was found that the forests in the study area fall in the category of secondary forest where stands are in the successive growing stages. Intensive sampling units with support from sufficient spatial data produced reliable estimates. This information is crucial for the reporting of forest resources that reside in an urban environment. With the new sets of data of the forest obtained from the forest inventory, UM management now have the ability to easily and accurately evaluate the composition and condition of the forest, and estimate the environmental services and aesthetic values. These are the first few steps that have been taken by UM towards improving the management of the urban forest on campus.
Serum glucose as an important predictor of delayed cerebral ischemia in angiogram-negative subarachnoid hemorrhage
Authors: Zhang Zeyu , Zhang Anke , Wang Xiaoyu , Fang Yuanjian , Liu Yibo , Luo Yujie , Lenahan Cameron , Chen Sheng , Zhang Jianmin
Published: February 2021

Background

Despite benign overall course, angiogram-negative subarachnoid hemorrhage (AN-SAH) still companies with risk of delayed cerebral ischemia (DCI). Serum glucose was previously found to be related to DCI occurrence in aneurysmal subarachnoid hemorrhage (aSAH), but this has not been confirmed in AN-SAH. The aim of this study was to clarify the significance of serum glucose in DCI prediction in AN-SAH patients.
Methods

We included patients with AN-SAH admitted to our hospital between January 2013 and December 2018. According to different bleeding patterns, patients were divided into perimesencephalic AN-SAH (PAN-SAH) and non-perimesencephalic AN-SAH (NPAH-SAH) patients. DCI was defined as symptomatic vasospasm or/and delayed cerebral infarction. A statistical analysis of the clinical, radiological, and laboratory risk factors of DCI was conducted. Logistic regression analysis was performed to identify the independent predictors of DCI.
Results

A total of 244 AN-SAH patients (mean age 55.7 years, 55.7% men) were included with 164 (67.2%) PAN-SAH patients and 80 (32.8%) NPAN-SAH patients. There were significant correlations between high DCI incidence and high serum glucose levels in the first five days after admission in both PAN-SAH patients and NPAN-SAH patients (p < 0.05). High admission serum glucose was significantly related to higher World Federation of Neurosurgeons Scale (WFNS) (p < 0.05). Multivariate logistic regression analysis showed that admission serum glucose (p = 0.001, OR 1.705, 95% CI 1.232–2.360) and WFNS (p = 0.008, OR 2.889, 95% CI 1.322–6.311) were both significant and independent predictors for DCI occurrence in PAN-SAH patients. Admission serum glucose (p = 0.016, OR 2.307, 95% CI 1.167–4.562), standard deviation (SD) of the serum glucose in the first three days after admission (p = 0.049, OR 5.684, 95% CI 1.006–32.114) and modified Fisher scale (mFS) (p = 0.033, OR 1.859, 95% CI 1.051–3.288) were significant and independent predictors for DCI occurrence in NPAN-SAH patients.
Conclusions

Serum glucose is an early biomarker to predict DCI risk in both PAN-SAH and NPAN-SAH patients, which has an important value in guiding intensive care in AN-SAH patients.
Does Meniscectomy Have Any Advantage Over Conservative Treatment of Degenerative Medial Meniscus Posterior Root Tear?
Authors: Lee Nam-Hun , Seo Hyoung-Yeon , Sung Myung-Jin , Na Bo-Ram , Song Eun-Kyoo , Seon Jong-Keun
Published: February 2021

Background: This study aimed to compare the clinical and radiological outcomes of arthroscopic meniscectomy and conservative treatment for degenerative MMPRT.Methods: From January 2007 to December 2014, 146 patients (Meniscectomy group, 90; Conservative group, 56) were evaluated. Clinical outcomes were assessed using the Visual Analog Scale, International Knee Documentation Committee subjective scoring scale, Tegner activity scale, and Lysholm knee scoring scale at the final follow-up. Radiologic outcomes evaluated the progression of osteoarthritis according to the K-L classification. We compared the hip-knee-ankle angle, medial proximal tibial angle, tibial posterior slope angle, and width of medial joint space. After an average follow-up of 6.3 years, the survivorship was analyzed using the Kaplan–Meier method. Results: Although all clinical outcomes had significantly improved in both groups after treatment, the VAS score (p=0.07), IKDC subjective score (p=0.18), Tegner activity scale score (p=0.08), and Lysholm knee score (p=0.53) showed no significant differences between the two groups at the final follow-up. The progression of OA according to the K-L classification, HKAA and width of medial joint space was significantly advanced in the meniscectomy group (p=0.03, 0.04, 0.03, respectively). The 10-year survival rates in the meniscectomy and conservative groups were 87% and 88%, respectively. Conclusions: This study demonstrated that both conservative treatment and meniscectomy provided symptomatic relief. However, it was confirmed that OA progression was more severe in the meniscectomy. We conclude that arthroscopic meniscectomy had no advantage over conservative treatment in terms of clinical outcomes and OA progression.
ASSERT (Acute Sacral inSufficiEncy fractuRe augmenTation): Perceptions in the Assessment and Treatment of Pubic Rami and Sacral Fragility Fractures Amongst Healthcare Professionals in Geriatric Medicine and Surgery.
Authors: Sahota Opinder , Leighton Paul , Cameron Maribel , Taylor Rachael , Ong Terence , Drummond Avril , Hendrick Paul , Quraishi Nasir , Salem Khalid
Published: February 2021

Background: Pubic rami fragility fractures are common in older people and result in significant morbidity and increased mortality. Co-existing fractures of the sacrum are common, but routinely missed. The aim of the study was to explore the perceptions in the assessment and treatment of pubic rami and sacral fragility fractures amongst healthcare professionals. Methods: We interviewed 14 participants about their experience in the assessment and treatment of patients presenting with pubic rami fragility fractures. Data was analysed using an inductive thematic approach.Results: The majority of patients presenting with a pubic rami fragility fracture were managed by geriatricians. However, many of the geriatricians were not aware that these fractures have a high association with co-existing sacral fragility fractures. Furthermore, they were not aware of the limitations of standard x-ray imaging, nor of the potential benefits of surgical intervention for sacral fragility fractures. Spinal surgeons recommended that early, more specialist imaging in patients with public rami fragility fractures failing to mobilise, would change clinical management, if found to have a coexisting sacral fragility fracture, amenable to surgical intervention. Conclusions: The awareness, assessment and management of sacral fragility fractures in patients presenting with pubic rami fragility fractures is poor amongst healthcare professional in geriatric medicine. Spinal surgeons in this study advocate early further imaging and surgical intervention in patients confirmed to have a concomitant sacral fragility fracture who are failing to mobilise.
PFKP Accelerates Malignant Features in Breast Cancer
Authors: Shibata Masahiro , Inaishi Takahiro , Ichikawa Takahiro , Kanda Mitsuro , Hayashi Masamichi , Soeda Ikumi , Takeuchi Dai , Takano Yuko , Tsunoda Nobuyuki , Kodera Yasuhiro , Kikumori Toyone
Published: February 2021

Purpose The platelet isoform of phosphofructokinase (PFKP) is one of the key enzymes in the glycolytic pathway. PFKP is highly expressed in several cancers, and it has been reported to be involved in the progression of cancer cells. However, its oncological role in breast cancer (BC) remains unclear. This study aimed to evaluate the function of PFKP in BC cells and its expression level in patients with BC.Methods The mRNA and protein expression of PFKP was evaluated in BC and non-cancerous mammary cell lines. Polymerase chain reaction (PCR) array analysis was conducted to evaluate the correlation between PFKP and 84 cancer-related genes. PFKP knockdown was conducted using small interfering RNA, and cell proliferation, invasiveness, and migration were analyzed. Furthermore, the association between PFKP mRNA expression and clinicopathological factors was investigated in 167 patients with BC.Results PFKP was highly expressed in estrogen receptor-negative and human epidermal growth factor receptor 2-negative BC cell lines. PCR array analysis demonstrated that PFKP expression level significantly correlated with that of transforming growth factor beta 1 and MYC proto-oncogene. PFKP knockdown significantly decreased the proliferation and invasiveness of MCF7, SK-BR-3, and MDA-MB-231 cells. Furthermore, cell migration was inhibited in SK-BR-3 and MDA-MB-231 cells. In the clinical specimens, patients with T2/T3/T4, lymph node metastasis, or stage II/III/IV showed higher expression of PFKP mRNA than patients with less severe disease.Conclusions PFKP is involved in promoting tumor-progressive oncological roles in BC cells across different subtypes. PFKP is considered a possible novel therapeutic target for BC.
Optimal vaccine strategy to control COVID-19 pandemic in middle-income countries: Modelling case study of Thailand
Authors: Luangasanatip Nantasit , Pan-Ngum Wirichada , Prawjaeng Juthamas , Saralamba Sompob , White Lisa , Aguas Ricardo , Clapham Hannah , Painter Christopher , Yi Wang , Isaranuwatchai Wanrudee , Teerawattananon Yot
Published: February 2021

Thailand is facing the dilemma of which groups to prioritise for the limited first tranche of vaccinations in 2021. A mathematical modelling analysis was performed to compare the potential short-term impact of allocating the available doses to either the high-risk group (over 65-year-olds) or the high incidence group (aged 20-39). Vaccinating the high incidence group with a vaccine with sufficiently high protection against infection (more than 50%) could provide enough herd effects to delay the expected epidemic peak, resulting in fewer deaths within the 12-month time horizon compared to vaccinating the same number of the high-risk group. After 12 months, if no further vaccination or other interventions were deployed, this strategy would lead to more deaths. With the right vaccine efficacy profile, targeting the high incidence groups could be a viable short-term component of the Thai vaccination strategy. These results and emerging evidence on vaccines and susceptibility suggest prioritisation guidelines should be more nuanced.
Fachbezogene Konzepte digitalen Lernens
Authors: Dertinger Andreas
Published: February 2021

Rezension zu

Brandt, Birgit, Leena Bröll, und Henriette Dausend, Hrsg. 2020. «Digitales Lernen in der Grundschule II. Aktuelle Trends in Forschung und Praxis». Münster ; New York: Waxmann. ISBN: 978-3-8309-4196-5. http://nbn-resolving.org/urn:nbn:de:0111-pedocs-205033.
Manifestações orais de arboviroses com ênfase em dengue, zika e chikungunya: revisão de literatura
Authors: Oliveira Amanda Alves de , Lacerda Maria Gabriella de Abreu , Barros Ariana Alves de Oliveira , Barreto Jaqueline Oliveira , Cruz José Henrique de Araújo , Freire Julliana Cariry Palhano , Ribeiro Eduardo Dias
Published: February 2021

Introdução: A dengue, zika e chikungunya são doenças virais que podem ser classificadas como arboviroses. Suas complicações clínicas são de larga escala e podem acometer a cavidade oral. Objetivos: Realizar uma revisão na literatura científica sobre as manifestações clínicas na cavidade oral provocadas pelas arboviroses transmitidas pelo mosquito Aedes Egipty. Metodologia: foram analisados 69 artigos científicos obtidos nas bases de dados PubMed e Scielo correspondentes ao período de 2000 a 2018, tomando por base os seguintes descritores: “dengue”, “zika” e “chikungunya” em associação com o termo “oral manifestation(s)”. Resultados: Nas infecções por dengue clássica os relatos mais frequentes foram manifestações mucocutâneas, vermelhidão e edema nas mucosas, enquanto na dengue hemorrágica o sangramento gengival é tido como mais frequente seguido de focos hemorrágicos pelas demais regiões da mucosa bucal; já a zika mostrou-se presente na saliva, úlceras aftosas, paralisia facial e complicações orais relacionadas à microcefalia; nos casos de infecção pelo vírus chikingunya foram relatados dor, queimação e sangramento na gengiva, incapacidade de deglutir e mastigar, halitose e dor na abertura da boca.  Conclusão: Há manifestações orais durante a infecção por Dengue, Zika e Chikungunya demostrando assim, a importância e a necessidade da realização de maiores pesquisas neste campo para instituição de protocolo clínico.
The personal dimension of the war in the Chronicles by Stanislav Aseyev
Authors: Nasminchuk Iryna
Published: February 2021

The author of the article analyzes the collection of journalistic articles by S. Aseeyv «In isolation», which attests to a purely personal experience of understanding the war. The relation in the texts of objective information and subjective impressions is considered. Reports, essays, reflections by S. Aseyev are analyzed in the context of time and life of the author. The journalistic work by S. Aseyev – the movement from fixation of the seen and experienced to the understanding of present and future of Ukraine in different coordinate systems – is the basis of modern perception of events in the occupied Donbass. In a substantive aspect, the collection can rule as an illustration of the tendency of intellectualization of the journalistic text by penetrating into the spheres of philosophy, psychology, and associativity. It is proved that the strategy of organizing journalistic text is an organic combination of autobiographical, documentary and essayistic discourses.
History of the Ukrainian party press in the periodicals (first half of the XX century)
Authors: Georgiievska Viktoriia
Published: February 2021

The article deals on the peculiarities of covering the history of some Ukrainian parties that were founded in Naddniprianska Ukraine in the early XXth century, in particular the Revolutionary Ukrainian Party (RUP) and the Ukrainian Social Democratic Worker’s Party (USDRP). The object of the study was the Parisian magazine «Tryzub / Trident», which paid special attention to the history of the formation of the RUP and the celebration of the thirty-year activity of this party. The following main methods were used, such as monitoring of bibliographic, historical and historical-journalistic sources, press clipping of individual publications (magazine «Tryzub / Trident»). Description, analysis, comparison, systematization and generalization made it possible to trace the stages of formation of the RUP (1900), its transformation into the USDRP (1905), to determine the main figures in the political processes of defending national and state interests of the first decades of the twentieth century.
La estigmatización analizada desde la fantasía de pureza, la extensión social de la repugnancia y las estrategias de inmunización
Authors: Girado Sierra Jesús David
Published: February 2021

Este artículo presenta un aporte teórico sobre las sociodinámicas de estigmatización y exclusión, lo cual resulta útil para futuras investigaciones en el campo de las ciencias sociales, al demarcar un fenómeno de estudio que es necesario explorar a fondo mediante etnografías de las representaciones sociales contemporáneas. El objetivo es analizar la extensión social de una emoción como la repugnancia afiliada a la fantasía de pureza, así como también reflexionar de forma crítica en torno a la inmunización como una variable biopolítica. Para lograr tal acometido, se abordan temas como el habitus, la conciencia de inadecuación, el fastidium y los dispositivos biopolíticos referidos a las estrategias: socio-eméticas, socio-herméticas y socio-profilácticas.
TRABALHO, PERFIL DOCENTE E CURRÍCULO: A FORMAÇÃO PROFISSIONAL INCONCLUSA NO ENSINO MÉDIO INTEGRADO DO IFPR
Authors: Fernandes Cássia Maria França de Sousa , Araújo Renan Bandeirante de , Batista Igor Mateus
Published: February 2021

Este artigo fundamentou-se nas análises desenvolvidas pelo Grupo de Pesquisa CNPq “Economia do Trabalho, Educação e Desenvolvimento Regional”, bem como dos resultados parciais de pesquisas realizadas junto ao Programa de Pós-Graduação em Ensino: Formação Docente Interdisciplinar da Universidade Estadual do Paraná. Realizou-se um recorte em que foram analisadas as incongruências formativas no Ensino Médio Integrado oferecido pelo Instituto Federal do Paraná (IFPR). Por meio de uma pesquisa qualitativa ancorada em análises bibliográficas e em fontes documentais, identificaram-se o perfil profissional docente do professor atuante no IFPR bem como a concepção de Ensino Profissional proposta nos Projetos Pedagógicos dos cursos das modalidades analisadas, cursos ofertados na mesorregião metropolitana de Curitiba, mais precisamente nos campi de Campo Largo, Curitiba e Pinhais. Os resultados alcançados revelaram que os cursos pesquisados têm sua ênfase centrada na formação para o mercado de trabalho, ainda que o Ensino Médio Integrado seja a última etapa da Educação Básica, portanto de caráter formativo. A prevalência da concepção formativa técnica unilateral implica que as aulas são ministradas, exceção à regra, por professores bacharéis, com reduzida carga horária das disciplinas de Ciências Humanas e Sociais no eixo Formação Técnica e Profissional.
POLYAMIDE 11 POROUS FILMS BY NIPS: THE INFLUENCE OF MISCIBILITY AND POLYMER CRYSTALLINE FORMATION IN PORES STRUCTURE AND MORPHOLOGY
Authors: Lima Rayanne , Pereira Thieres , Silva Filho Eloi
Published: February 2021

This study described the morphology, crystallinity, thermal and mechanical characterization of Polyamide 11 (PA11) porous film prepared by non-solvent induced phase separation (NIPS) method using formic acid (FA) as solvent. In addition, the miscibility of PA11/FA/H2O system was performed to generate a ternary phase diagram. The porous films morphology was investigated by Scanning Electronic Microscopy (SEM) analysis, the crystallinity by X-Ray Diffractometer (XRD) and thermal study by Differential Scanning Calorimetry (DSC). A cellulosic reinforcement was used in porous films and the stress-strain analysis was performance by Dynamic Mechanical Analysis (DMA). The porous films were prepared with polymer composition of 15, 20 and 25 wt%. The porous films showed different microstructure in function of polymer concentration. The 20 and 25 wt% porous films showed micropores structures with medium pores diameters between 0-10µm calculated by image analysis. The XRD analysis show predominance of α crystalline form of polymer at 20 and 25 wt% porous films. The degree of crystallinity increases with polymer concentration increase. The stress-strain analysis of porous films shows a proportional dependence of Young’s modulus with the increase of polymer concentration in each film.
Population Pharmacokinetics of Levetiracetam: A Systematic Review
Authors: Methaneethorn Janthima , Leelakanok Nattawut
Published: February 2021

Background:

The use of levetiracetam (LEV) has been increasing given its favorable pharmacokinetic profile. Numerous population pharmacokinetic studies for LEV have been conducted. However, there are some discrepancies regarding factors affecting its pharmacokinetic variability. Therefore, this systematic review aimed to summarize significant predictors for LEV pharmacokinetics as well as the need for dosage adjustments.

Methods:

We performed a systematic search for population pharmacokinetic studies of LEV conducted using a nonlinear-mixed effect approach from PubMed, Scopus, CINAHL Complete, and Science Direct databases from their inception to March 2020. Information on study design, model methodologies, significant covariate-parameter relationships, and model evaluation was extracted. The quality of the reported studies was also assessed.

Results:

A total of 16 studies were included in this review. Only two studies were conducted with a two-compartment model, while the rest were performed with a one-compartment structure. Bodyweight and creatinine clearance were the two most frequently identified covariates on LEV clearance (CLLEV). Additionally, postmenstrual age (PMA) or postnatal age (PNA) were significant predictors for CLLEV in neonates. Only three studies externally validated the models. Two studies conducted pharmacodynamic models for LEV with relatively small sample size.

Conclusion:

Significant predictors for LEV pharmacokinetics are highlighted in this review. For future research, a population pharmacokinetic-pharmacodynamic model using a larger sample size should be conducted. From a clinical perspective, the published models should be externally evaluated before clinical implementation.
Xanthohumol: A Metabolite with Promising Anti-Neoplastic Potential
Authors: Tuli Hardeep S. , Aggarwal Vaishali , Parashar Gaurav , Aggarwal Diwakar , Parashar Nidarshana C. , Tuorkey Muobarak J. , Varol Mehmet , Sak Katrin , Kumar Manoj , Buttar Harpal S.
Published: February 2021

The overwhelming globalburden of cancer has posed numerous challenges and opportunities for developing anti-cancer therapies. Phytochemicalshave emerged as promising synergistic compounds with potential anti-cancer effects to supplement chemo- and immune-therapeutic regimens. Anti cancer synergistic effects have been investigated in the interaction between phytocompounds derived from flavonoids such as quercetin, apigenin, kaempferol, hesperidin, emodin etc., and conventional drugs. Xanthohumol is one of the prenylatedphytoflavonoid that has demonstrated key anti-cancer activities in in vitro (anti proliferation of cancer cell lines) and in vivo(animal models of xenograft tumours)studies, and has been explored from different dimensions for targeting cancer subtypes. In the last decade, xanthohumol has been investigated how it induces the anti-cancer effects at cellular and molecular level.The different signalling cascades and targets of xanthohumolare summarized in thisreview.Overall, this reviewsummarizes the current advances made in the field of natural compounds with special reference to xanthohumol and its promising anti-cancer effectsto inhibit tumour progression.The present review hasalso touched upon the potential of xanthohumol transitioning into a lead candidate from nano-therapy viewpoint along with the challenges which need to be addressed for extensive pre-clinical and clinical anti-cancer studies.
Fabrics Recommendation for Fashion Design by Using Fuzzy Logic and
Rough Sets
Authors: Dong Min , Zeng Xianyi , Koehl Ludovic , Zhang Junjie
Published: February 2021

Background:

Fabric is one of the key and vital design factors in fashion design. However, selection of relevant fabrics is rather complex for designers and managers due to the complexity of criteria at different levels.

Introduction:

In this paper, we propose a new fabric recommendation model in order to quickly realize fabric selection from non-technical fashion features only and predict fashion features from any fabric technical parameters. This approach is extremely significant for fashion designers who do not completely master fabric technical details. It is also very useful for fabric developers who have no knowledge on fashion markets and fashion consumers.

Method:

The proposed fabric recommendation model has been built by exploiting designers’ professional knowledge and consumers’ preferences. Concretely, we first use fuzzy sets for formalizing and interpreting measured technical parameters and linguistic sensory properties of fabrics and then model the relation between the technical parameters and sensory properties by using rough sets. Next, we model the relation between fashion themes and sensory properties using fuzzy relations. By combining these two models, we establish a hybrid model characterizing the relation between fashion themes and technical parameters.

Result:

The proposed model has been validated through a real fabric recommendation case for designer’s specific requirements. We can find that the proposed model is efficient since the averaged value of prediction errors is 8.57%, which does not exceed 10% (generally considered as allowable range of human perception error).

Conclusion:

The proposed model will constitute one important component for establishing an intelligent recommender system for garment design, enabling to support innovations in textile/apparel industry in terms of mass customization and e-shopping.
Operações SAAL Porto — valor patrimonial e proposta de salvaguarda
Authors: Fernandes João Luís da Mota Torres
Published: February 2021

The present study aims to explicit the various positive heritage values inherent to the dwellings built in the city of Oporto as part of the operations undertook by the Service of Local Ambu‑ latory Support (SAAL). Acknowledging these structures as testimony of a defining moment for the establishment of national identity – post 25th April 1974 –the appeal and validity of the safekeeping of these architectures will be grounded on the analysis of other case studies, relevant to the apprecia‑ tion of Social Housing as a strong contribute towards the enrichment of national culture, finalizing with a presentation of heritage management methodologies applicable to the case in question.
«Descubrir» y «descubrirse» en el románico: un ejemplo catalán de patrimonio de la humanidad
Authors: Garganté Llanes Maria
Published: February 2021

The aim of this work is to present a case study on the identification between Romanesque art and national identity in Catalonia, an association that emerged in the framework of the emer‑ gence of national movements at the end of the 19th century, but that was recovered a century later when the process for the declaration of the Romanesque churches of the Boí Valley as a world heri‑ tage site by UNESCO began. The identification of the Romanesque with a «national art» is reinforced in this case because it is a Romanesque art located in the heart of the Pyrenees, with the strong symbolic value of the mountain as the «cradle» of the Catalan nation. We will analyse the World Heritage process and its effects in the context of a small territory, with a scarce population and dependent to a great extent on the seasonality of tourism.
Teaching Japanese Elementary School Students Programming and Computational Thinking in a CLIL Environment
Authors: Kazahaya Yuka
Published: February 2021

In Japan there is an effort to add programming and English language to the curriculum at an earlier age so children develop an easy familiarity with both. Most programming languages use scripts based on English which presents an additional problem in teaching programming in countries
where English is not the first language. Associate Professor Yuka Kazahaya, based at Okayama Prefectural University, is developing and promoting different methods of teaching both programming and English language in Japan.
International comparative study on fair organizational management in Japanese companies in ASEAN
Authors: Kano Ikuya
Published: February 2021

When studying notions of fairness in the workplace, it is important to consider the point of views of employees and how what they believe to be fair or unfair might have negative impacts on the company as a whole. For instance, changes to the working hours, paying different wages to
people in similar positions, or redundancies, might well affect the motivation of employees, leading to falls in effort, productivity, efficiency and general worker happiness. There has been a significant amount of research dedicated to understanding employee perceptions of fairness in the
workplace. Such research falls under the general banner of organisational justice, where researchers attempt to understand how an employee's attitude and behaviour is affected by the behaviour of an organisation. Professor Ikuya Kano from the University of Hyogo has embarked on a three-year
research project related to the theories of organisational justice. Kano is working alongside Katsunori Kaneko and is performing a comparative study between Japanese workers and local workers in ASEAN countries (Mainly Thailand, Philippines, Indonesia, Vietnam and Laos).
Comprehensive research on corporate disclosure theory
Authors: Ochi Nobuhito
Published: February 2021

Incorporating the dynamics of capital markets into the driving force, starting from comparable ESG (environmental, social and governance) information, will contribute to the circulation of the ecosystem that connects business and a sustainable society. Professor Nobuhito Ochi, Department
of Policy Studies, Shobi University, Japan, is deepening research toward the realization of an ESG ecosystem, with a basic perspective of improving market discipline for corporate activities related to ESG and leveraging the improvement of comparability of non-financial information. Ochi's
work comprehensively examines the externalities of social common capital held by modern society, and uses the thinking framework of incentive analysis as a methodological foundation, and aims to develop interdisciplinary disclosure theory to improve inefficiency caused by asymmetry of information.
Measures that would contribute to the realization of social value under a framework that utilizes disclosure discipline, in order to draw out incentives for coping with the cause for externality control related to natural capital, social capital (culture and community) and institutional capital
(finance and audit).
 Ochi is conducting research that involves looking at a broad range of corporate activities surrounding disclosure theory, ESG and AI, including lead companies to an ideal ESG information disclosure process through the utilization of AI. This work includes looking
at how companies can buffer communities from the negative aspects of a corporation's activities and exploring the disclosure of information including social, natural and institutional capital. Ochi has presented a theory of corporate disclosure and a theory of assurance of non-financial information
that allows for better control of costs and benefits that are social common capital rather than financial capital. The theory operates under a framework that uses the discipline of disclosure and contributes to the realization of social value and, ultimately, Ochi is seeking to help build
a financial and economical society that contributes to societal wellbeing.
Rockefeller Foundation and medical research in Korea and Taiwan under Japanese rule
Authors: Matsuda Toshihiko
Published: February 2021

Much historical information is yet to be uncovered, such as how knowledge was formed in certain parts of the world, including in Japan and Korea. Professor Toshihiko Matsuda, International Research Center for Japanese Studies, Japan, is investigating, in a global context, the body of
knowledge formed in Japan, and it's outer influence, including on Taiwan, Korea and Manchuria in the modern era and on public health study and education. This needs to be clarified as, in Japan, there is a tendency to believe that Korea's knowledge and high-level education system came about
from its colonial era, but South Korean researchers don't believe this to be the case. One line of investigation for Matsuda concerns a famous bacteriologist in prewar Japan called Kiyoshi Shiga who spent his last decade as a researcher in colonial Korea. Through this research, Matsuda is
seeking to understand the position occupied by colonial Korea in the course of global medical history. He is using historical records to establish an understanding of how the history of public health as an academic discipline was introduced into colonial Korea, including using the documents
of the Rockefeller Archives Center to decipher Shiga's role in introducing public health into Korea. In the process, Matsuda is filling gaps regarding how knowledge was imparted, pooled and shared between Japan and South Korea and emphasising that the information shaped in colonial Korea is
closely connected to Western knowledge.
Решетки населенностей, создаваемые в газе атомов водорода с помощью ультрафиолетовых аттосекундных импульсов
Authors: Архипов Р.М. , Архипов М.В. , Пахомов А.В. , Артемьев Ю.М. , Розанов Н.Н.
Published: February 2021

The possibility of population density grating in a gas of hydrogen atoms using a pair
ultraviolet (UV) attosecond pulses that do not overlap in the medium is studied. Wherein
the central frequency of the pulses can both coincide with the frequency of the resonant transition 1−2 from the main state in the first excited state (the main line of the Lyman series), and be detuned from it. The results of numerical calculations are in agreement with the analytical values ​​obtained on the basis of approximate solution of Schrödinger equation using perturbation theory. It is shown that under resonant excitation the greatest efficiency of the grating is achieved with an increase in the pulse duration. When nonresonant excitation, on the contrary, the system is more efficiently excited by short quasi-unipolar subcycle pulses than bipolar multicycle pulses. The results obtained can be
applicable to coherent excitation of a single atom (thin layer) using a pair of UV pulses.
The possibility of controlling the modulation depth of the gratings by changing the carrier
envelope phase (CEP) of attosecond pulses is shown.
Awareness and Potential Impacts of the Medicalization of Internet Gaming Disorder: Cross-sectional Survey Among Adolescents in China (Preprint)
Authors: Yu Yanqiu , Li Ji-Bin , Lau Joseph T F
Published: February 2021

BACKGROUND

The Eleventh Revision of International Classification of Diseases (ICD-11) newly listed gaming disorder, including internet gaming disorder (IGD), as a disease. The level of awareness and potential positive and negative impacts of this medicalization among adolescents were unknown.

OBJECTIVE

This study investigated the levels, associated factors, and potential positive and negative impacts of awareness of the medicalization of IGD among adolescents in China.

METHODS

In a cross-sectional survey, 1343 middle school students in Guangzhou, China, self-administered an anonymous questionnaire in classrooms (October to December 2019). Three risk subgroups were identified: those who scored ≥5 items in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition checklist (IGD-S), those who self-perceived having IGD currently (IGD-PC), and those who self-perceived having IGD within 12 months (IGD-P12M).

RESULTS

Of the internet gamers, 48.3% (460/952) were aware of the medicalization of IGD; they were more likely to belong to the IGD-P12M/IGD-S risk subgroups. Within the IGD-PC/IGD-P12M (but not IGD-S) risk subgroups, IGD medicalization awareness was positively associated with favorable outcomes (reduced internet gaming time in the past 12 months, seeking help from professionals if having IGD, and fewer maladaptive cognitions). After being briefed about the ICD-11 inclusion of IGD, 54.2% (516/952) and 32.8% (312/952) expressed that it would lead to the reduction of gaming time and help-seeking behaviors, respectively; however, 17.9% (170/952), 21.5% (205/952), 15.9% (151/952), and 14.5% (138/952) perceived self-doubt for being diseased, stronger pressure from family members, negative emotional responses, and labeling effect, respectively. With a few exceptions, such perceived positive or negative impacts were stronger among the IGD-S, IGD-PC, and IGD-P12M risk subgroups.

CONCLUSIONS

The exploratory study shows that the medicalization of IGD may have benefits that need maximization and potentially harmful effects that need minimization. Future studies should test the efficacies of health promotion that increases IGD medicalization awareness.
Smoking Cessation Using Wearable Sensors: Protocol for a Microrandomized Trial (Preprint)
Authors: Hernandez Laura M , Wetter David W , Kumar Santosh , Sutton Steven K , Vinci Christine
Published: February 2021

BACKGROUND

Cigarette smoking has numerous health consequences and is the leading cause of morbidity and mortality in the United States. Mindfulness has the ability to enhance resilience to stressors and can strengthen an individual’s ability to deal with discomfort, which may be particularly useful when managing withdrawal and craving to smoke.

OBJECTIVE

This study aims to evaluate feasibility results from an intervention that provides real-time, real-world mindfulness strategies to a sample of racially and ethnically diverse smokers making a quit attempt.

METHODS

This study uses a microrandomized trial design to deliver mindfulness-based strategies in real time to individuals attempting to quit smoking. Data will be collected via wearable sensors, a study smartphone, and questionnaires filled out during the in-person study visits.

RESULTS

Recruitment is complete, and data management is ongoing.

CONCLUSIONS

The data collected during this feasibility trial will provide preliminary findings about whether mindfulness strategies delivered in real time are a useful quit smoking aid that warrants additional investigation.

CLINICALTRIAL

Clinicaltrials.gov NCT03404596; https://clinicaltrials.gov/ct2/show/NCT03404596

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/22877