bluuebunny/crossref_metadata_2025 huggingface dataset:
Predictive value of synaptic plasticity for functional decline in patients with multiple sclerosis
Authors: Balloff Carolin , Janßen Lisa Kathleen , Hartmann Christian Johannes , Meuth Sven Günther , Schnitzler Alfons , Penner Iris-Katharina , Albrecht Philipp
Published: June 2024

Background

Previous research suggested that quadripulse (QPS)-induced synaptic plasticity is associated with both cognitive and motor function in patients with multiple sclerosis (MS) and does not appear to be reduced compared to healthy controls (HCs).

Objective

This study aimed to explore the relationship between the degree of QPS-induced plasticity and clinically significant decline in motor and cognitive functions over time. We hypothesized that MS patients experiencing functional decline would exhibit lower levels of baseline plasticity compared to those without decline.

Methods

QPS-induced plasticity was evaluated in 80 MS patients (56 with relapsing-remitting MS and 24 with progressive MS), and 69 age-, sex-, and education-matched HCs. Cognitive and motor functions, as well as overall disability status were evaluated annually over a median follow-up period of 2 years. Clinically meaningful change thresholds were predefined for each outcome measure. Linear mixed-effects models, Cox proportional hazard models, logistic regression, and receiver-operating characteristic analysis were applied to analyse the relationship between baseline plasticity and clinical progression in the symbol digit modalities test, brief visuospatial memory test revised (BVMT-R), nine-hole peg test (NHPT), timed 25-foot walk test, and expanded disability status scale.

Results

Overall, the patient cohort showed no clinically relevant change in any functional outcome over time. Variability in performance was observed across time points in both patients and HCs. MS patients who experienced clinically relevant decline in manual dexterity and/or visuospatial learning and memory had significantly lower levels of synaptic plasticity at baseline compared to those without such decline (NHPT: β = −0.25, p = 0.02; BVMT-R: β = −0.50, p = 0.005). Receiver-operating characteristic analysis underscored the predictive utility of baseline synaptic plasticity in discerning between patients experiencing functional decline and those maintaining stability only for visuospatial learning and memory (area under the curve = 0.85).

Conclusion

Our study suggests that QPS-induced plasticity could be linked to clinically relevant functional decline in patients with MS. However, to solidify these findings, longer follow-up periods are warranted, especially in cohorts with higher prevalences of functional decline. Additionally, the variability in cognitive performance in both patients with MS and HCs underscores the importance of conducting further research on reliable change based on neuropsychological tests.
Frontiers and hotspots in comorbid epilepsy and depression: a bibliometric analysis from 2003 to 2023
Authors: Liu Gui-Yu , Fu Fan-Jia , Chou Ying-Xin , Ye Ming-Sha , Ouyang Yi-Lin , Yan Ming-De , Pan Lei , Li Wei-Peng , Xie Wei
Published: June 2024

Background

Epilepsy ranks among the most common neurological disorders worldwide, frequently accompanied by depression as a prominent comorbidity. This study employs bibliometric analysis to reveal the research of comorbid epilepsy and depression over the past two decades, aiming to explore trends and contribute insights to ongoing investigations.

Methods

We conducted a comprehensive search on the Web of Science Core Collection database and downloaded relevant publications on comorbid epilepsy and depression published from 2003 to 2023. VOSviewer and CiteSpace were mainly used to analyze the authors, institutions, countries, publishing journals, reference co-citation patterns, keyword co-occurrence, keyword clustering, and other aspects to construct a knowledge atlas.

Results

A total of 5,586 publications related to comorbid epilepsy and depression were retrieved, with a general upward trend despite slight fluctuations in annual publications. Publications originated from 121 countries and 636 institutions, with a predominant focus on clinical research. The United States led in productivity (1,529 articles), while Melbourne University emerged as the most productive institution (135 articles). EPILEPSY & BEHAVIOR was the journal with the highest publication output (1,189 articles) and citation count. Keyword analysis highlighted emerging trends, including “recognitive impairment” and “mental health,” indicating potential future research hotspots and trends.

Conclusion

This study is one of the first to perform a bibliometric analysis of the 20-year scientific output of comorbid epilepsy and depression. While research has trended upwards, ambiguity in pathogenesis and the absence of standardized diagnostic guidelines remain concerning. Our analysis offers valuable guidance for researchers, informing that this might be a strong area for future collaborations.
Hearing rehabilitation of adults with auditory processing disorder: a systematic review and meta-analysis of current evidence-based interventions
Authors: Crum Rachel , Chowsilpa Sanathorn , Kaski Diego , Giunti Paola , Bamiou Doris-Eva , Koohi Nehzat
Published: June 2024

Background

For adults with auditory processing disorder (APD), listening and communicating can be difficult, potentially leading to social isolation, depression, employment difficulties and certainly reducing the quality of life. Despite existing practice guidelines suggesting treatments, the efficacy of these interventions remains uncertain due to a lack of comprehensive reviews. This systematic review and meta-analysis aim to establish current evidence on the effectiveness of interventions for APD in adults, addressing the urgent need for clarity in the field.

Methods

Following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, we conducted a systematic search across MEDLINE (Ovid), Embase (Ovid), Web of Science and Scopus, focusing on intervention studies involving adults with APD. Studies that met the inclusion criteria were grouped according to intervention with a meta-analysis only conducted where intervention, study design and outcome measure were comparable.

Results

Out of 1,618 screened records, 13 studies were included, covering auditory training (AT), low-gain hearing aids (LGHA), and personal remote microphone systems (PRMS). Our analysis revealed: AT, Mixed results with some improvements in speech intelligibility and listening ability, indicating potential benefits but highlighting the need for standardized protocols; LGHA, The included studies demonstrated significant improvements in monaural low redundancy speech testing (p < 0.05), suggesting LGHA could enhance speech perception in noisy environments. However, limitations include small sample sizes and potential biases in study design. PRMS, Demonstrated the most consistent evidence of benefit, significantly improving speech testing results, with no additional benefit from combining PRMS with other interventions.

Discussion

PRMS presents the most evidence-supported intervention for adults with APD, although further high-quality research is crucial for all intervention types. The establishment and implementation of standardized intervention protocols alongside rigorously validated outcome measures will enable a more evidence-based approach to managing APD in adults.
Fruit and vegetable intake and the risk of non-alcoholic fatty liver disease: a meta-analysis of observational studies
Authors: Wang Rui , Yan Ruijuan , Jiao Junzhe , Li Feilong , Zhang Haibo , Chang Zhanjie , Wei Hailiang , Yan Shuguang , Li Jingtao
Published: June 2024

Purpose

This systematic review and meta-analysis of clinical observational studies aims to clarify the correlation between the intake levels of fruits and vegetables and non-alcoholic fatty liver disease (NAFLD).

Materials and methods

PubMed, Embase, Web of Science, and the Cochrane Library were searched for studies on the association between vegetable or fruit intake with the risk of NAFLD from the foundation of each database up until September 2023. The relative risk (OR) and the 95% confidence interval (CI) were pooled for both the highest and lowest consumption levels of vegetables and fruits to explore their association with the incidence of NAFLD.

Results

The meta-analysis encompassed 11 studies with a total of 493,682 patients. A higher consumption of vegetables (OR = 0.78, 95% CI = 0.67–0.91) and fruits (OR = 0.88, 95% CI = 0.83–0.93) was found to have a negative correlation with the risk of NAFLD, denoting an inverse association. This correlation, however, varied among different ethnic groups and gender.

Conclusions

Our results indicate that increased consumption of vegetables and fruits is associated with a reduced likelihood of developing NAFLD.

Systematic review registration

https://www.crd.york.ac.uk/PROSPERO/#searchadvanced, identifier: CRD42023460430.
EGFR kinase domain duplication in lung adenocarcinoma with systemic and intracranial response to a double-dose of furmonertinib: a case report and literature review
Authors: Lin Hong , Yang Zhengyuan , Li Zhifeng , Chen Junwei , Wang Hongbiao , Lin Yingcheng
Published: June 2024

Background

EGFR kinase domain duplication (EGFR-KDD) is an infrequent oncogenic driver mutation in lung adenocarcinoma. It may be a potential target benefit from EGFR-tyrosine kinase inhibitors (TKIs) treatment.

Case presentation

A 66-year-old Chinese male was diagnosed with lung adenocarcinoma in stage IVb with brain metastases. Next-generation sequencing revealed EGFR-KDD mutation. The patient received furmonertinib 160mg daily for anti-cancer treatment and obtained therapeutic efficacy with partial response (PR). Progression-free survival (PFS) duration from monotherapy was 16 months. With slow progressions, combined radiotherapy and anti-vascular targeted therapy also brought a continuous decrease in the tumors. The patient has an overall survival (OS) duration of more than 22 months and still benefits from double-dose furmonertinib.

Conclusions

This report provided direct evidence for the treatment of EGFR-KDD to use furmonertinib. A Large-scale study is needed to confirm this preliminary finding.
Case report: Drug-eluting bead transcatheter arterial chemoembolization in liver metastasis and retroperitoneal lymph node metastases of renal cell carcinoma: effective local therapy with the first report
Authors: Qiu Zhenkang , Ji Junjie , Zhang Shuo , Wang Song
Published: June 2024

The liver is the fourth most common site of metastasis in renal cell carcinoma (RCC), which is usually treated with systemic therapies and local treatments. However, local treatments are challenging in RCC patients with liver metastasis who failed in first-line systemic therapy. Here, we report a case of a patient with both liver-dominant RCC metastasis and recurrence in the operative site who had failed in first-line targeted therapy plus immunotherapy, received drug-eluting bead transcatheter arterial chemoembolization (DEB-TACE), and achieved a complete response.
BRCA-associated hereditary male cancers: can gender affect the prevalence and spectrum of germline pathogenic variants?
Authors: Fanale Daniele , Corsini Lidia Rita , Brando Chiara , Randazzo Ugo , Bono Marco , Pedone Erika , Perez Alessandro , Sciacchitano Roberta , Cancelliere Daniela , Piraino Paola , Giurintano Ambra , Bazan Russo Tancredi Didier , Ferraro Pietro , Rinaldi Gaetana , Spinnato Valeria , Gennusa Vincenzo , Pernice Gianfranco , Vieni Salvatore , Pantuso Gianni , Russo Antonio , Bazan Viviana
Published: June 2024

Introduction

Although hereditary male neoplasms are quite rare, individuals harbouring germline BRCA1/2 pathogenic variants (PVs) may have a risk of developing tumours associated with Hereditary Breast and Ovarian Cancer (HBOC) syndrome, including male breast (MBC), prostate (PCa) and pancreatic (PC) cancers, and melanoma. Women and men showed a comparable genetic architecture of cancer susceptibility, but there are some gender-specific features. Since little is known about cancer genetic susceptibility in male population, our study was aimed at investigating the frequency of BRCA1/2 PVs in men with HBOC syndrome-associated tumors, in order to understand whether differences in gender may reflect in the prevalence and spectrum of germline alterations.

Patients and methods

We retrospectively collected and analysed clinical information of 352 HBOC-associated male cancer patients genetically tested for germline BRCA1/2 PVs by Next-Generation Sequencing analysis, enrolled, from February 2018 to January 2024, at the “Regional Center for the prevention, diagnosis and treatment of rare and heredo-familial tumors of adults” of the University-Hospital Policlinico “P. Giaccone” of Palermo (Italy).

Results

Our investigation revealed that 7.4% of patients was carrier of a germline BRCA PV, with an almost total prevalence of BRCA2 alterations. In particular, 65.4% of BRCA-positive patients developed MBC, 19.2% had PC, 11.6% developed PCa, and only 3.8% had melanoma. Specifically, MBC individuals showed a BRCA-associated genetic predisposition in 17% of cases, whereas patients with PCa or PC exhibited a lower frequency of BRCA2 PVs, taking into account the current national criteria for access to germline genetic testing.

Discussion

Our study showed a high heterogeneity in prevalence of germline BRCA2 PVs among men which could reflect a potential gender-specific genetic heterogeneity. Therefore, BRCA-associated male tumours could be due to BRCA2 PVs different from those usually detected in women. In the event that it is demonstrated, in future, that male cancers are genetically distinct entities from those female this could improve personalized risk evaluation and guide therapeutic choices for patients of both sexes, in order to obtain a gender equality in cancer care.
Elemental biomapping of human tissues suggests toxic metals such as mercury play a role in the pathogenesis of cancer
Authors: Pamphlett Roger , Bishop David P.
Published: June 2024

Toxic metals such as mercury, lead, and cadmium have multiple carcinogenic capacities, including the ability to damage DNA and incite inflammation. Environmental toxic metals have long been suspected to play a role in the pathogenesis of cancer, but convincing evidence from epidemiological studies that toxic metals are risk factors for common neoplasms has been difficult to gain. Another approach is to map the location of potentially toxic elements in normal human cells where common cancers originate, as well as in the cancers themselves. In this Perspective, studies are summarized that have used elemental biomapping to detect toxic metals such as mercury in human cells. Two elemental biomapping techniques, autometallography and laser ablation-inductively coupled-mass spectrometry imaging, have shown that multiple toxic metals exist in normal human cells that are particularly prone to developing cancer, and are also seen in neoplastic cells of breast and pancreatic tumors. Biomapping studies of animals exposed to toxic metals show that these animals take up toxic metals in the same cells as humans. The finding of toxic metals such as mercury in human cells prone to cancer could explain the increasing global incidence of many cancers since toxic metals continue to accumulate in the environment. The role of toxic metals in cancer remains to be confirmed experimentally, but to decrease cancer risk a precautionary approach would be to reduce emissions of mercury and other toxic metals into the environment from industrial and mining activities and from the burning of fossil fuels.
A scientometric analysis of research on the role of NMDA receptor in the treatment of depression
Authors: Chen Xulin , Wang Xian , Li Caijuan , Zhang Yao , Feng Shanwu , Xu Shiqin
Published: June 2024

Background

There have been numerous studies on NMDA receptors as therapeutic targets for depression. However, so far, there has been no comprehensive scientometric analysis of this field. Thus, we conducted a scientometric analysis with the aim of better elucidating the research hotspots and future trends in this field.

Methods

Publications on NMDAR in Depression between 2004 and 2023 were retrieved from the Web of Science Core Collection (WoSCC) database. Then, VOSviewer, CiteSpace, Scimago Graphica, and R-bibliometrix—were used for the scientometric analysis and visualization.

Results

5,092 qualified documents were identified to scientometric analysis. In the past 20 years, there has been an upward trend in the number of annual publications. The United States led the world in terms of international collaborations, publications, and citations. 15 main clusters were identified from the co-cited references analysis with notable modularity (Q-value = 0.7628) and silhouette scores (S-value = 0.9171). According to the keyword and co-cited references analysis, treatment-resistant depression ketamine (an NMDAR antagonist), oxidative stress, synaptic plasticity, neuroplasticity related downstream factors like brain-derived neurotrophic factor were the research hotspots in recent years.

Conclusion

As the first scientometric analysis of NMDAR in Depression, this study shed light on the development, trends, and hotspots of research about NMDAR in Depression worldwide. The application and potential mechanisms of ketamine in the treatment of major depressive disorder (MDD) are still a hot research topic at present. However, the side effects of NMDAR antagonist like ketamine have prompted research on new rapid acting antidepressants.
Development of hepatic steatosis in male and female mule ducks after respective force-feeding programs
Authors: Atallah Elham , Trehiou Sabrina , Alquier-Bacquie Valérie , Lasserre Frédéric , Arroyo Julien , Molette Caroline , Remignon Hervé
Published: June 2024

Male and female mule ducks were subjected to a force-feeding diet to induce liver steatosis as it is generally done only with male ducks for the production of foie gras. The different biochemical measurements indicated that the course of hepatic steatosis development was present in both sexes and associated with a huge increase in liver weight mainly due to the synthesis and accumulation of lipids in hepatocytes. In livers of male and female ducks, this lipid accumulation was associated with oxidative stress and hypoxia. However, certain specific modifications (kinetics of lipid droplet development and hepatic inflammation) indicate that female ducks may tolerate force-feeding less well, at least at the hepatic level. This is in contradiction with what is generally reported concerning hepatic steatosis induced by dietary disturbances in mammals but could be explained by the very specific conditions imposed by force-feeding. Despite this, force-feeding female ducks seems entirely feasible, provided that the final quality of the product is as good as that of the male ducks, which will remain to be demonstrated in future studies.
Mitochondria in COVID-19: from cellular and molecular perspective
Authors: Rurek Michał
Published: June 2024

The rapid development of the COVID-19 pandemic resulted in a closer analysis of cell functioning during β-coronavirus infection. This review will describe evidence for COVID-19 as a syndrome with a strong, albeit still underestimated, mitochondrial component. Due to the sensitivity of host mitochondria to coronavirus infection, SARS-CoV-2 affects mitochondrial signaling, modulates the immune response, modifies cellular energy metabolism, induces apoptosis and ageing, worsening COVID-19 symptoms which can sometimes be fatal. Various aberrations across human systems and tissues and their relationships with mitochondria were reported. In this review, particular attention is given to characterization of multiple alterations in gene expression pattern and mitochondrial metabolism in COVID-19; the complexity of interactions between SARS-CoV-2 and mitochondrial proteins is presented. The participation of mitogenome fragments in cell signaling and the occurrence of SARS-CoV-2 subgenomic RNA within membranous compartments, including mitochondria is widely discussed. As SARS-CoV-2 severely affects the quality system of mitochondria, the cellular background for aberrations in mitochondrial dynamics in COVID-19 is additionally characterized. Finally, perspectives on the mitigation of COVID-19 symptoms by affecting mitochondrial biogenesis by numerous compounds and therapeutic treatments are briefly outlined.
Insecticidal activity and underlying molecular mechanisms of a phytochemical plumbagin against Spodoptera frugiperda
Authors: Sun Xiaoyu , Li Wenxuan , Yang Shuang , Ni Xueqi , Han Shengjie , Wang Mengting , Zhen Cong’ai , Huang Xinzheng
Published: June 2024

Introduction

Plumbagin is an important phytochemical and has been reported to exhibit potent larvicidal activity against several insect pests, However, the insecticidal mechanism of plumbagin against pests is still poorly understood. This study aimed to investigate the insecticidal activities of plumbagin and the underlying molecular mechanisms against a devastating agricultural pest, the fall armyworm Spodoptera frugiperda.

Methods

The effects of plumbagin on S. frugiperda larval development and the activities of two detoxification enzymes were initially examined. Next, transcriptomic changes in S. frugiperda after plumbagin treatment were investigated. Furthermore, RNA-seq results were validated by qPCR.

Results

Plumbagin exhibited a high larvicidal activity against the second and third instar larvae of S. frugiperda with 72 h LC50 of 0.573 and 2.676 mg/g, respectively. The activities of the two detoxification enzymes carboxylesterase and P450 were significantly increased after 1.5 mg/g plumbagin treatment. Furthermore, RNA-seq analysis provided a comprehensive overview of complex transcriptomic changes in S. frugiperda larvae in response to 1.5 mg/g plumbagin exposure, and revealed that plumbagin treatment led to aberrant expression of a large number of genes related to nutrient and energy metabolism, humoral immune response, insect cuticle protein, chitin-binding proteins, chitin synthesis and degradation, insect hormone, and xenobiotic detoxification. The qPCR results further validated the reproducibility and reliability of the transcriptomic data.

Discussion

Our findings provide a valuable insight into understanding the insecticidal mechanism of the phytochemical plumbagin.
How and when does proactive personality predict career adaptability? A study of the moderated mediation model
Authors: Li Hui , Xu Ziyue , Song Suhao , Jin Hui
Published: June 2024

In the present study, we explored the relationship between proactive personality and career adaptability to construct a cross-level moderated mediation model based on the conservation of resources (COR) theory. By conducting a time-lagged study involving three data collection points from 587 employees across 104 teams in China, we examined how and when proactive personality predicts employees' career adaptability using strengths use as a mediator and managerial coaching as boundary conditions. The results revealed that proactive personality predicted strengths use, which, in turn, influenced career adaptability, with managerial coaching moderating the indirect relationship between proactive personality and career adaptability. Consequently, our findings suggest that, in contexts where managerial coaching lacks guidance, facilitation, and inspiration, a proactive personality encourages employees to leverage their strengths, subsequently enhancing their career adaptability. Finally, we discuss the theoretical and practical implications of our findings, address limitations, and propose directions for future research.
A comparison of perceptual-cognitive skills in expert and non-expert sports officials: a systematic review and meta-analysis
Authors: Wu Yidong , Yang Ziqi , Wang Rishu , Zeng Hongtao , Zhang Qi
Published: June 2024

Introduction

The purpose of this study is to systematically compare and assess the differences in perceptual-cognitive skills between expert and non-expert sports officials, and further explore the potential differences caused by different types of sports officials, in order to provide a more comprehensive understanding of the perceptual-cognitive skills of sports officials.

Methods

Relevant literature published before 31 December 2022 was searched in four English databases. Review Manager 5.4 and Stata 12.0 software were used for meta-analysis and bias test.

Results

Expert sports officials are significantly more accurate in their decision-making than non-expert sports officials, and exhibit a large amount of effect size (SMD = 1.09; 95%CI: 0.52, 1.66; P < 0.05). Expert sports officials had significantly fewer number of fixations than non-expert sports officials and showed a moderate amount of effect size (SMD = 0.71; 95%CI: 1.25, 0.17; P < 0.05). Expert sports officials' duration of fixation (SMD = 0.23; 95%CI: 0.25, 0.71; P = 0.35) were not significantly different from non-expert sports officials.

Discussion

It can be seen that there are differences in the Perceptual-cognitive skills of expert and non-expert sports officials. Decision-making accuracy can serve as an important indicator for distinguishing the perceptual-cognitive skills of expert and non-expert sports officials. Number of fixations can serve as important indicators to differentiate the perceptual-cognitive skills of monitors.

Systematic review registration

https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=418594, identifier: CRD42023418594.
A bibliometric review of positive psychology and well-being research in Africa
Authors: Fadiji Angelina Wilson , Khumalo Itumeleng P. , Wissing Marié Philipina , Appiah Richard
Published: June 2024

Positive Psychology rapidly developed into an influential field of study and intervention, initially situated in Psychology, and later becoming multidisciplinary. Research interest in the study of (psychological) well-being has gained global popularity, with increasing salience in Africa. Although the global trends of these developments are relatively well-known, a bibliometric analysis of positive psychology research in Africa was necessary to shed light on the present hotspots and trends and future trajectories in this region of the world. The data source of the present bibliometric analysis study was Scopus, from which Positive Psychology and well-being research literature from Africa between 1983 and 2023 were searched. Using biblioshiny and VOSviewer, the 622 extracted articles were analysed, from which findings about the current condition, research hotspots, and thematic developmental patterns could be made. Africa experienced an initial slow growth period from 1983 until 2005, after which a rapid growth in research productivity, relevance and impact was experienced. In this regard, the results show that the focal point of scientific productivity is South Africa, with the dominance of South African institutions, particularly the North-West University, from where most positive psychology research is produced and cited. Even with potential access to international journal, African researchers seem to prefer to place their publications in the regional journals such as Journal of Psychology in Africa and South African Journal of Psychology. The research reviewed tends to be characterised by more dominant thematic clusters of positive psychology, psychological well-being, and subjective well-being, with a focus on human individuals. An increasing concern for contextual factors and potential antecedents and dynamics of well-being is also observed. The findings provide a good map from which identification of future research priorities can be deduced. As such, we speculate that future positive psychology research in Africa ought to be concerned with the following: greater distribution and intercountry collaborations across the continent, questions of conceptual clarity of terms, better understanding of contextual factors which influence well-being, and well-being research embracing the complexity of bio-psycho-social-ecological well-being, and science concerned with health-promotion interventions.
The methods and baseline characteristics of a multi-site randomized controlled trial evaluating mindfulness-based relapse prevention in conjunction with peer support to improve adherence to medications for opioid use disorders
Authors: Mumba Mercy Ngosa , Mugoya George Tongi , Allen Rebecca S. , Glenn Andrea L. , Richman Joshua , Ghera Anchal , Butler Austin , Rogers Blossom , Granger Teresa Ann , Davis Lori L.
Published: June 2024

Introduction

Medications for opioid use disorders (MOUD) remain the gold standard for treating OUD, but treatment initiation and adherence remain challenging. Exclusive utilization of pharmacotherapy as a treatment modality for OUD is sub-optimal, and a combination of psychotherapies and pharmacotherapies is recommended. General trends indicate the benefits of peer mentoring and MBRP separately. Therefore, we hypothesize that the combined effect of MBRP and Peer mentoring will produce synergistic improvements in MOUD adherence compared to an enhanced twelve-step facilitation (TSF).

Methods

This paper describes the methods and baseline characteristics of a multi-site randomized controlled trial evaluating the effectiveness of a combination of MBRP and peer support (MiMP) compared to an enhanced TSF in improving adherence to MOUD. Both MiMP and TSF are 12-week manualized protocols that utilize licensed therapists. The interventions are delivered in weekly group sessions that last about 75–90 minutes per session. The primary outcome is MOUD adherence. Secondary and exploratory outcomes include relapse, cravings, depression, anxiety, stress, quality of life, and pain catastrophizing.

Results

The participants’ ages ranged from 21 years to 77 years, with a mean age of 44.5 (SD ± 11.5 years). There was an almost equal distribution of gender and place of residence. Overall, 51.9% (n=54) of participants identified as female and 48.1% (n=50) were male. Similarly, 51.9% (n=54) of participants resided in urban areas, while 48.1% (n=50) resided in rural areas. Participants identified as either black or white, with over three-quarters identifying as white (77.9%, n= 81) and 22.1% (n= 23) as black. Most participants randomized to the 12-step facilitation group were white (93.1%). Relationships and employment status were well distributed between categories. Over half of the participants reported some college or higher education. Over 90% of the participants made less than $75,000 per year. Some participants indicated that they had both public and private health insurance.

Discussion and conclusion

This study is innovative in several ways including combining MBRP and peer support, addressing comorbid mental health issues among individuals with OUD, utilizing manualized protocols, and evaluating of both physiological and self-reported measures in assessing cortisol reactivity as a predictor of relapse and treatment outcomes.
What to take up from the patient’s talk? The clinician’s responses to the patient’s self-disclosure of their subjective experience in the psychiatric intake interview
Authors: Savander Enikö É. , Voutilainen Liisa , Hintikka Jukka , Peräkylä Anssi
Published: June 2024

During psychiatric diagnostic interviews, the clinician’s question usually targets specific symptom descriptions based on diagnostic categories for ICD-10/DSM-5 (2, 3). While some patients merely answer questions, others go beyond to describe their subjective experiences in a manner that highlights the intensity and urgency of those experiences. By adopting conversation analysis as a method, this study examines diagnostic interviews conducted in an outpatient clinic in South Finland and identifies sequences that divulge patients’ subjective experiences. From 10 audio-recorded diagnostic interviews, 40 segments were selected where patients replied to medically or factually oriented questions with their self-disclosures. The research focus was on the clinicians’ responses to these disclosures. We present five sequential trajectories that the clinicians offered third-position utterances in response to their patients’ self-disclosure of subjective experiences. These trajectories include the following: 1) the clinician transfers the topic to a new agenda question concerning a medical or factual theme; 2) the clinician presents a follow-up question that selects a topic from the patient’s self-disclosure of a subjective experience that may orient either towards the medical/factual side or the experiential side of the patient’s telling; 3) the clinician provides an expert interpretation of the patient’s self-disclosure of his or her subjective experience from the clinician’s expert perspective; 4) the clinician gives advice that orients mainly to a treatment recommendation or to another activity; and 5) the clinician presents a formulation that focusses on the core of their patient’s self-disclosure of his or her subjective experience from the patient’s perspective. In addition, we present what these responsive practices invoke from the patient in the next turn. We argue that an awareness of these strategies facilitates both the diagnosis and an appropriate therapeutic relationship during the psychiatric assessment interview. Finally, we discuss the clinical significance of our results regarding the patient’s agency and the clinician’s more conscious patient-centred orientation in the psychiatric assessment procedure.
Minding mentalizing - convergent validity of the Mentalization Breakdown Interview
Authors: Ulvestad Dag Anders , Johansen Merete Selsbakk , Kvarstein Elfrida Hartveit , Pedersen Geir , Wilberg Theresa
Published: June 2024

Objectives

Mentalizing difficulties are central to borderline personality disorder (BPD), have severe consequences, and are an explicit focus in mentalization-based treatment. The significance of mentalizing capacity as a predictor or mediator of change is however still uncertain due to a scarcity of research. The Mentalization Breakdown Interview (MBI) was developed as a time saving tool for studying psychotherapy processes and outcome in borderline pathology. This study aimed to investigate the convergent validity of reflective functioning (RF) ratings based on the MBI (MBI-RF) by a comparison with the gold standard, i.e., RF assessments based on the Adult Attachment Interview (AAI-RF). A secondary aim was to investigate how MBI-RF relates to core symptoms of BPD, levels of functional impairment and symptom distress compared with AAI-RF.

Method

Forty-five patients with BPD or significant BPD traits were included. MBI-RF and AAI-RF were rated using the Reflective Functioning Scale. Levels of MBI-RF and AAI-RF and the correlation between the measures were calculated, as well as their associations with the Difficulties in Emotion Regulation Scale, Levels of Personality Functioning-Brief Form 2.0, Work and Social Adjustment Scale, Patient Health Questionnaire, Depression, Generalized Anxiety Disorder-7, self-harm, suicide attempts, and PD diagnostics.

Results

The correlation between MBI-RF and AAI-RF was 0.79 (p<0.01), indicating high convergent validity. There were few significant associations between MBI-RF and AAI-RF and clinical measures.

Conclusions

The study provides support for the convergent validity of the MBI as a BPD-focused RF assessment method. The MBI has the potential as a time saving, reliable and valid method to be applied in treatment research on patients with borderline pathology. The results indicate that measures of MBI-RF and AAI-RF are different from clinical symptoms.

Clinical trial registration

ClinicalTrials.gov ID NCT04157907.
A social prospect theory of intergroup relations explains the occurrence of incremental progressive social change
Authors: Cropley Ian , Jost John T.
Published: June 2024

Throughout modernity, incremental progress has been a common pattern of social change. We propose a novel social prospect theory of intergroup relations that can explain the prevalence of this pattern by distinguishing between two types of social change: progressive and regressive. Progressive social change is defined as that which results in a new social system or regime, whereas regressive social change is that which results in a return to an earlier social system or regime. According to our proposed theory, which is an extension of prospect theory, (a) progressive social change represents possible gains for members of disadvantaged groups and potential losses for members of advantaged groups, whereas regressive social change represents possible gains for members of advantaged groups and potential losses for members of disadvantaged groups; (b) loss avoidance is a stronger motivator than gain-seeking; and (c) the likely outcomes of reverting to a previous state of affairs can be predicted with more certainty than outcomes of establishing a new and untested social system. When these three principles are applied to the context of group decision-making by members of advantaged and disadvantaged groups, a motivational tendency toward incremental progressive social change results. This is because members of advantaged and disadvantaged groups alike will be strongly motivated to avoid losing ground, but members of disadvantaged groups will be more strongly motivated than members of advantaged groups, because there is more certainty associated with the outcomes of regressive vs. progressive social change. Thus, social prospect theory provides a motivational explanation for the occurrence of gradual, incremental progressive changes despite the many sociopolitical disadvantages faced by beneficiaries.
Dietary complex probiotic supplementation changed the composition of intestinal short-chain fatty acids and improved the average daily gain of weaned piglets
Authors: Zhao Jianfei , Xie Zhuoya , Zheng Meiling , Tang Wenjie , Diao Hui , Yin Heng
Published: June 2024

Probiotics are a group of active microorganisms that form colonies within the body and alter the composition of the flora in a specific area to provide benefits to the host. In this study, a total of 96 Duroc × Landrace × Yorkshire weaned piglets with an initial body weight (BW) of 8.56 ± 0.53 kg were employed in a randomized complete block design for a 28-day experiment. Pigs were randomly divided into two treatment groups: the control group (CON) and the complex probiotic group (CON + 0.2% probiotics), respectively. The study found that through the 28-day experiment, the average daily gain (ADG) of the complex probiotic group was significantly higher than that of the CON (p < 0.05). However, compared with the CON, the feed conversion efficiency significantly decreased on days 0–14 (p < 0.05). The addition of dietary complex probiotic significantly increased the villus height (VH) of duodenum and ileum, acetate, propionate, butyrate, and total short-chain fatty acids (SCFAs) in feces, and decreased fecal methyl mercaptans, acetic acid, and CO2 (p < 0.05). It concluded that feeding weaned piglets 0.2% complex probiotic increased the VH of duodenum and ileum, as well as changed the content of SCFAs in feces. This ultimately led to an increase in ADG.
An Analytical Reentry Solution Based Online Time-Coordinated A* Path Planning Method for Hypersonic Gliding Vehicles Considering No-Fly-Zone Constraint
Authors: Xie Zihan , Wei Changzhu , Cui Naigang , Guan Yingzi
Published: June 2024

To meet the time-coordinated requirement of hypersonic gliding vehicles to reach a single target simultaneously in the presence of no-fly-zone constraints, this paper proposes a time-coordinated A* path planning method considering multiple constraints. The path planning method is designed based on an analytical steady gliding path model and the framework of the A* algorithm. Firstly, an analytical steady gliding path model is designed based on a quadratic function-type altitude-velocity profile. It can derive the control commands explicitly according to the desired terminal altitude and velocity, thus establishing a mapping between the terminal states and the control commands. Secondly, the node extension method of the A* algorithm is improved based on the mapping. Taking the terminal states as new design variables, a feasible path-node set is produced by a one-step integration using the control commands derived according to different terminal states. This node extension method ensures the feasibility of the path nodes while satisfying terminal constraints. Next, the path evaluation function of the A* algorithm is modified by introducing a heuristic switching term to select the most proper node as a waypoint, aiming to minimize the arrival time deviation. Meanwhile, introducing the penalty items into the path evaluation function satisfies the no-fly-zone constraints, process constraints, and control variable constraints. Finally, an online time-coordinated method is proposed to determine a commonly desired arrival time for several hypersonic gliding vehicles. It eliminates the need to specify the arrival time in advance and improves the capability to deal with sudden threats, increasing the path planning method’s online application capability. The proposed method can achieve online time-coordinated multi-constraint path planning for several hypersonic gliding vehicles, whose effectiveness and superiority are verified by simulations.
Can Digital Finance Promote Rice Production? Evidence from Sichuan Province, China
Authors: Li Wenjing , Lin Gege , Dou Qingqing , Chandio Abbas Ali , Larik Shahbaz Ali , Liu Yan
Published: June 2024

The rapid development of digital finance has effectively reduced financial challenges in rural regions and created new prospects for agricultural production. This article examines the impact of digital financial development on rice production in Sichuan Province using the 2011–2021 Peking University Digital Financial Inclusion Index and data from 20 prefecture-level cities, as well as a fixed effects model. The mechanism of action is also discussed. The findings reveal that the advancement of digital finance plays an important role in boosting the expansion of rice production, and that digital finance influences rice output by increasing farmers’ willingness to participate in insurance and increasing the availability of credit. A heterogeneity analysis reveals that digital finance has a substantial effect on mountainous and economically poor areas. As a result, this article suggests that the breadth and depth of usage of rural digital finance, as well as the development of rural digital financial services in underdeveloped areas, should be expanded.
Safety and Quality of Grapes: Elemental, Isotopic and Chemometric Analysis from Montepulciano d’Abruzzo PDO Chain
Authors: Rapa Mattia , Ferrante Marco , Rodushkin Ilia , Conti Marcelo Enrique
Published: June 2024

This study explored the elemental, isotopic, and chemometric profiles of Montepulciano d’Abruzzo grapes to ensure the safety and quality of wines produced under the Protected Designation of Origin (PDO) label. Essential nutrients, such as K, P, Ca, Mg, and Fe, were quantified alongside toxic elements, like Hg, Pb, Cd, and As, to evaluate the potential health impacts and compliance with food safety standards. Isotopic analysis provided a powerful tool for geographical authentication, essential for verifying the grapes’ PDO status and preventing market fraud. Chemometric techniques, including Principal Component Analysis (PCA) and Multivariate Classification Methods, were employed to interpret complex datasets, enabling the identification of unique patterns and clusters that signify quality attributes and possible contamination. The study’s findings not only enhance the traceability and authentication processes essential for PDO labels but also offer valuable insights into the safety and quality management of Montepulciano d’Abruzzo grapes, addressing the implications for growers, regulators, and consumers, thereby supporting sustainable viticulture and robust quality control in global wine production.
Effects of Potassium Nutrition on Corn (Zea mays L.) Physiology and Growth for Modeling
Authors: Thenveettil Naflath , Reddy Krishna N. , Reddy Kambham Raja
Published: June 2024

Potassium (K) deficiency in corn is an emerging concern, especially when the crop is exposed to stress conditions. The insufficient replenishment of K in soil heightens the severity. A good K management requires adequate knowledge of its effect on plant growth and physiology. A sunlit growth chamber study was conducted under five levels of potassium concentrations, 100% (control; 193 ppm), 40%, 20%, 5%, and 0%, using modified Hoagland’s nutrient solution applied at first leaf stage and continued until tasseling. The plant growth and development were monitored at different growth stages. Physiological parameters were measured at the tasseling stage. Significant differences (p < 0.05 to 0.001) in plant growth and physiological parameters were recorded in response to potassium rates. The 0% K treatment reduced the leaf K content and addition of leaf area day−1 by 85% and 8%, respectively, compared to the control. The rate of total biomass accumulation reduced to 5.4 g day−1 under 0% K compared to 7.7 g day−1 under the control. The root-to-shoot ratio increased to 0.33 at 5% K compared to 0.16 at the control treatment. The photosynthetic rate was reduced by 30% and 35% under 5% and 0% potassium concentrations, respectively, compared to the control. The 0% K deficiency decreased the stomatal conductance by 60% over control, lowering the internal CO2 level and transpiration. Linear and quadratic relationships were observed between leaf K content and electron transport rate (R2 = 0.98) and transpiration rate (R2 = 0.96), respectively. The functional relationships generated from this study will help improve corn models for field applications.
Multi-Feature Fusion Recognition and Localization Method for Unmanned Harvesting of Aquatic Vegetables
Authors: Guan Xianping , Shi Longyuan , Yang Weiguang , Ge Hongrui , Wei Xinhua , Ding Yuhan
Published: June 2024

The vision-based recognition and localization system plays a crucial role in the unmanned harvesting of aquatic vegetables. After field investigation, factors such as illumination, shading, and computational cost have become the main difficulties restricting the identification and positioning of Brasenia schreberi. Therefore, this paper proposes a new lightweight detection method, YOLO-GS, which integrates feature information from both RGB and depth images for recognition and localization tasks. YOLO-GS employs the Ghost convolution module as a replacement for traditional convolution and innovatively introduces the C3-GS, a cross-stage module, to effectively reduce parameters and computational costs. With the redesigned detection head structure, its feature extraction capability in complex environments has been significantly enhanced. Moreover, the model utilizes Focal EIoU as the regression loss function to mitigate the adverse effects of low-quality samples on gradients. We have developed a data set of Brasenia schreberi that covers various complex scenarios, comprising a total of 1500 images. The YOLO-GS model, trained on this dataset, achieves an average accuracy of 95.7%. The model size is 7.95 MB, with 3.75 M parameters and a 9.5 GFLOPS computational cost. Compared to the original YOLOv5s model, YOLO-GS improves recognition accuracy by 2.8%, reduces the model size and parameter number by 43.6% and 46.5%, and offers a 39.9% reduction in computational requirements. Furthermore, the positioning errors of picking points are less than 5.01 mm in the X direction, 3.65 mm in the Y direction, and 1.79 mm in the Z direction. As a result, YOLO-GS not only excels with high recognition accuracy but also exhibits low computational demands, enabling precise target identification and localization in complex environments so as to meet the requirements of real-time harvesting tasks.