bluuebunny/crossref_metadata_2025 huggingface dataset:
Technological applications of volatile corrosion inhibitors
Authors: Valdez Benjamin , Schorr Michael , Cheng Nelson , Beltran Ernesto , Salinas Ricardo
Published: January 2018

The objective of this review is to create a body of knowledge on the theoretical and practical aspects of corrosion inhibition to prevent and/or to eliminate corrosion in natural environments such as water, air, and acids and in industrial facilities such as oil, natural gas, concrete, paints and coatings, electronics, and military equipment. Corrosion inhibitors (CIs) and volatile corrosion inhibitors (VCIs) are applied in diverse forms such as powders, pellets, aqueous, or solvent solutions and in impregnated papers; closed in pouches and sachets; and added to coatings. Natural CIs are extracted by water or organic solvents from suitable plants. They represent the advanced trends of corrosion management based on green chemistry.
Effect of Slip and Convective Boundary Conditions on Entropy Generation in a Porous Channel due to Micropolar Fluid Flow
Authors: Srinivasacharya D. , Himabindu K.
Published: January 2018

This article presents the effect of convective heating and velocity slip on flow generation of an incompressible micropolar fluid through a porous channel. The flow is induced by a constant axial pressure gradient applied in the flow direction. The non-linear governing equations are linearized using the quasilinearization technique and then solved by Chebyshev spectral collocation method. The numerical values of the velocity, microrotation and temperature are used to derive the corresponding entropy generation number and Bejan number within the porous channel. The influences of pertinent parameters on velocity, microrotation, temperature, entropy generation and Bejan number are discussed through graphs. It is observed that the convective heating tends to increase the entropy generation within the channel.
Composite Absorber in Collision Simulations of a Bus
Authors: Sháněl Vít , Španiel Miroslav
Published: January 2018

This paper details the numerical modeling of composite absorbers and an assessment of the influence of such deformation elements on a bus during frontal collision with a car. The absorber itself is designed as an assembly of thin-walled composite wound tubes oriented in the vehicle direction of travel. During the impact the tubes are crushed, causing energy absorption. Crash simulations were performed at various speeds using differing scenarios with the deformational member as well as without it. Comparative diagrams of force and velocity of the car and deformation of the bus structure were assessed
Joint Shaft Test Stand
Authors: Pakosta Jiří , Achtenová Gabriela
Published: January 2018

The article focuses on description of design of the test stand for shafts with universal joints and constant velocity joints. The shafts can be loaded by torque at specified speed of rotation, while retaining the possibility of setting a variable angle between input and output. All shafts are instrumented with contactless signal transmission. In addition, ventilator simulates the cooling derived from the driving speed.
Some Selected Legal Aspects of the Activity Rules in Relation to the Financial Agent´s Clients
Authors: Slezáková Andrea
Published: January 2018

The activities of financial agents deserve our attention as we can currently observe their growing share on the intermediation of financial services. The quantity of products and services offered by financial market segments requires a continuous education and the monitoring of the current legislation. Financial agents help their clients to find a financial product, which fulfills their specific needs. The client´s decision depends on the extent of the information a financial agent provides to him. The legislator imposes an obligation to act when performing financial intermediation in compliance with the principles of fair business relations, with professional care and in the interest of rights and legitimate interests of a client. However, the legislation does not define these terms. This paper aims to outline and analyze procedures in order to perform financial intermediation in accordance with regulatory requirements.
Strategic analysis methods and their influence on stability and development of small and medium-sized enterprises in the Czech Republic
Authors: Straková Jarmila
Published: January 2018

Strategic analysis of business environment influences the growing efficiency, stability, and sustainability of enterprises. The entry is aimed at analyzing internal and external strategic methods between profit-making and non-profit-making enterprises from the perspective of their sector differentiation and size categorization focusing on small and medium-sized enterprises. The entry highlights the managers’ knowledge of the individual methods and their usability in business practice. The research was conducted based on a sample of 456 enterprises from the entire Czech Republic using a Student’s T-test of the differences of two percentages and the Fisher’s exact test. The conclusion of the entry is dedicated to the results of the tests, as well as new trends that are used in the area of strategic analysis and which have been indicated as a part of the set of tested enterprises.
Productivity of Czech logistic firms: quality orientation, entrants and multinationals
Authors: Vokoun Marek
Published: January 2018

The paper analyses logistics industry in Czech Republic and analyzes clusters and groups of one hundred companies that were active in the market in 2014. Analysis is based on the economic theory of endogenous growth and technological spillovers of multinational firms. They have the know-how and technology, which makes them more productive than local firms which tries to catch up the leaders and try to get as much knowledge as possible. This paper contributes to this theory. Key findings for this transitional economy is that quality certification is not beneficial for labor productivity and earnings, there are differences among multinational firms in terms of output efficiency and they are on average more productive than local firms, older firms are less productive than younger, but entrants are not more profitable than older firms.
Multistep Cylindrical Structure Analysis at Normal Incidence Based on Water-Substrate Broadband Metamaterial Absorbers
Authors: Fang Chonghua
Published: January 2018

A new multistep cylindrical structure based on water-substrate broadband metamaterial absorbers is designed to reduce the traditional radar cross-section (RCS) of a rod-shaped object. The proposed configuration consists of two distinct parts. One of these components is formed by a four-step cylindrical metal structure, whereas the other one is formed by a new water-substrate broadband metamaterial absorber. The designed structure can significantly reduce the radar cross section more than 10 dB from 4.58 to 18.42 GHz which is the 86.5 % bandwidth of from C-band to 20 GHz. The results of measurement show reasonably good accordance with the simulated ones, which verifies the ability and effect of the proposed design.
Encoding of Spatial Attention by Primate Prefrontal Cortex Neuronal Ensembles
Authors: Backen Theda , Treue Stefan , Martinez-Trujillo Julio C.
Published: January 2018

Single neurons in the primate lateral prefrontal cortex (LPFC) encode information about the allocation of visual attention and the features of visual stimuli. However, how this compares to the performance of neuronal ensembles at encoding the same information is poorly understood. Here, we recorded the responses of neuronal ensembles in the LPFC of two macaque monkeys while they performed a task that required attending to one of two moving random dot patterns positioned in different hemifields and ignoring the other pattern. We found single units selective for the location of the attended stimulus as well as for its motion direction. To determine the coding of both variables in the population of recorded units, we used a linear classifier and progressively built neuronal ensembles by iteratively adding units according to their individual performance (best single units), or by iteratively adding units based on their contribution to the ensemble performance (best ensemble). For both methods, ensembles of relatively small sizes (n< 60) yielded substantially higher decoding performance relative to individual single units. However, the decoder reached similar performance using fewer neurons with the best ensemble building method compared with the best single units method. Our results indicate that neuronal ensembles within the LPFC encode more information about the attended spatial and nonspatial features of visual stimuli than individual neurons. They further suggest that efficient coding of attention can be achieved by relatively small neuronal ensembles characterized by a certain relationship between signal and noise correlation structures.
Meis1 Coordinates Cerebellar Granule Cell Development by Regulating Pax6 Transcription, BMP Signaling and Atoh1 Degradation
Authors: Owa Tomoo , Taya Shinichiro , Miyashita Satoshi , Yamashita Mariko , Adachi Toma , Yamada Koyo , Yokoyama Miwa , Aida Shogo , Nishioka Tomoki , Inoue Yukiko U. , Goitsuka Ryo , Nakamura Takuro , Inoue Takayoshi , Kaibuchi Kozo , Hoshino Mikio
Published: January 2018

Cerebellar granule cell precursors (GCPs) and granule cells (GCs) represent good models to study neuronal development. Here, we report that the transcription factor myeloid ectopic viral integration site 1 homolog (Meis1) plays pivotal roles in the regulation of mouse GC development. We found that Meis1 is expressed in GC lineage cells and astrocytes in the cerebellum during development. Targeted disruption of the Meis1 gene specifically in the GC lineage resulted in smaller cerebella with disorganized lobules. Knock-down/knock-out (KO) experiments for Meis1 andin vitroassays showed that Meis1 binds to an upstream sequence of Pax6 to enhance its transcription in GCPs/GCs and also suggested that the Meis1–Pax6 cascade regulates morphology of GCPs/GCs during development. In the conditional KO (cKO) cerebella, many Atoh1-positive GCPs were observed ectopically in the inner external granule layer (EGL) and a similar phenomenon was observed in cultured cerebellar slices treated with a bone morphogenic protein (BMP) inhibitor. Furthermore, expression of Smad proteins and Smad phosphorylation were severely reduced in the cKO cerebella and Meis1-knock-down GCPs cerebella. Reduction of phosphorylated Smad was also observed in cerebellar slices electroporated with a Pax6 knock-down vector. Because it is known that BMP signaling induces Atoh1 degradation in GCPs, these findings suggest that the Meis1–Pax6 pathway increases the expression of Smad proteins to upregulate BMP signaling, leading to degradation of Atoh1 in the inner EGL, which contributes to differentiation from GCPs to GCs. Therefore, this work reveals crucial functions of Meis1 in GC development and gives insights into the general understanding of the molecular machinery underlying neural differentiation from neural progenitors.

SIGNIFICANCE STATEMENTWe report that myeloid ectopic viral integration site 1 homolog (Meis1) plays pivotal roles in the regulation of mouse granule cell (GC) development. Here, we show Meis1 is expressed in GC precursors (GCPs) and GCs during development. Our knock-down and conditional knock-out (cKO) experiments andin vitroassays revealed that Meis1 is required for proper cerebellar structure formation and forPax6transcription in GCPs and GCs. The Meis1–Pax6 cascade regulates the morphology of GCs. In the cKO cerebella, Smad proteins and bone morphogenic protein (BMP) signaling are severely reduced and Atoh1-expressing GCPs are ectopically detected in the inner external granule layer. These findings suggest that Meis1 regulates degradation of Atoh1 via BMP signaling, contributing to GC differentiation in the inner EGL, and should provide understanding into GC development.
Producing a Radio Housewife
Authors: Wang Jennifer Hyland
Published: January 2018

This article examines how the writers and publicists behind the pioneering radio serial Clara, Lu 'n' Em circulated representations of gendered labor in early prime-time and daytime network radio. Through their satiric impersonations of “syntax-scrambling” midwestern housewives, the careful promotion of the three young stars, and their sale of Super Suds to American housewives, they established gender norms for both the production and the consumption of commercial messages in early radio. The creative team supporting Clara, Lu 'n' Em helped write the script for how broadcasters and sponsors could negotiate economic pressures and cultural concerns about women's paid work in the young medium. By embracing domesticity, the program negotiated the division then developing between prime-time and daytime programming, modeled modern consumer behavior for a mass female audience, and pledged its support for gendered spheres of labor.
Gender and Queer Fan Labor on Tumblr
Authors: Anselmo Diana W.
Published: January 2018

Dominated by LGBTQ+ and female-identified fans from various backgrounds, Tumblr blogs dedicated to queer readings of the BBC television series Sherlock (2010–ongoing) are a breeding ground for less-discussed forms of unremunerated queer labor: utopian, heuristic, and care work. In their digital fanworks, Tumblr queer users marry crafts associated with domestic heterosexual femininity (collage and scrapbooking) with established female fan practices (slashing and shipping) to articulate complex sexual and gender identities and navigate neuro-divergent mental health statuses. This article examines the shifts real-time digital interactivity and transmedia storytelling have introduced to viewer/producer power relations. Unpacking “queer cryptography” as a form of reception labor offers a feminist reading of the diverse modes of LGBTQ+ identification, kinship, and activism performed by queer female viewers on Tumblr, while questioning the vulnerability and possible exploitation of the unsanctioned affective labor produced by such a desperately underrepresented demographic.
Estimating Barriers to Gene Flow from Distorted Isolation-by-Distance Patterns
Authors: Ringbauer Harald , Kolesnikov Alexander , Field David L , Barton Nicholas H
Published: January 2018

Ringbauer et al. introduce a novel method to estimate barriers to gene flow in a two-dimensional population. Their inference scheme utilizes geographically...

In continuous populations with local migration, nearby pairs of individuals have on average more similar genotypes than geographically well-separated pairs. A barrier to gene flow distorts this classical pattern of isolation by distance. Genetic similarity is decreased for sample pairs on different sides of the barrier and increased for pairs on the same side near the barrier. Here, we introduce an inference scheme that uses this signal to detect and estimate the strength of a linear barrier to gene flow in two dimensions. We use a diffusion approximation to model the effects of a barrier on the geographic spread of ancestry backward in time. This approach allows us to calculate the chance of recent coalescence and probability of identity by descent. We introduce an inference scheme that fits these theoretical results to the geographic covariance structure of bialleleic genetic markers. It can estimate the strength of the barrier as well as several demographic parameters. We investigate the power of our inference scheme to detect barriers by applying it to a wide range of simulated data. We also showcase an example application to an Antirrhinum majus (snapdragon) flower-color hybrid zone, where we do not detect any signal of a strong genome-wide barrier to gene flow.
Corpora and corpus linguistics revisited: an interview with Karin Aijmer
Authors: Šinkūnienė Jolanta
Published: January 2018

...
Flöck, Ilka. 2016. Requests in American and British English. A contrastive multi-method analysis. Amsterdam/Philadelphia: John Benjamins, pp. 264.
Authors: Maíz-Arévalo Carmen
Published: January 2018

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Viewpoint: Recent Advances in Intracoronary Imaging for Vasa Vasorum Visualisation
Authors: Nishimiya Kensuke ,   Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan, Matsumoto Yasuharu ,   Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan, Shimokawa Hiroaki ,   Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
Published: January 2018

The coronary adventitia harbours the vasa vasorum (VV), which has a diameter of 50–300 μm and plays an important role as a network of nutrient blood vessels to the arterial wall. The VV is thought to be involved in the development of coronary atherosclerosis. Recent advances in the field of intracoronary imaging, including optical coherence tomography, have enabled us to visualise coronary VV in humans in vivo and increased the clinical relevance of the VV in patients with coronary artery disease.
QT Prolongation and Malignant Arrhythmia: How Serious a Problem?
Authors: Antoniou Christos-Konstantinos ,   First University Department of Cardiology, Hippokration Hospital, Athens, Greece, Dilaveris Polychronis ,   First University Department of Cardiology, Hippokration Hospital, Athens, Greece, Manolakou Panagiota ,   First Department of Cardiology, Korgialenion–Benakion/Hellenic Red Cross Hospital, Athens, Greece, Galanakos Spyridon ,   First University Department of Cardiology, Hippokration Hospital, Athens, Greece, Magkas Nikolaos ,   First University Department of Cardiology, Hippokration Hospital, Athens, Greece, Gatzoulis Konstantinos ,   First University Department of Cardiology, Hippokration Hospital, Athens, Greece, Tousoulis Dimitrios ,   First University Department of Cardiology, Hippokration Hospital, Athens, Greece
Published: January 2018

QT prolongation constitutes one of the most frequently encountered electrical disorders of the myocardium. This is due not only to the presence of several associated congenital syndrome but also, and mainly, due to the QT-prolonging effects of several acquired conditions, such as ischaemia and heart failure, as well as multiple medications from widely different categories. Propensity of repolarization disturbances to arrhythmia appears to be inherent in the function of and electrophysiology of the myocardium. In the present review the issue of QT prolongation will be addressed in terms of pathophysiology, arrhythmogenesis, treatment and risk stratification approaches. Although already discussed in literature, it is hoped that the mechanistic approach of the present review will assist in improved understanding of the underlying changes in electrophysiology, as well as the rationale for current diagnostic and therapeutic approaches.
Inflammation Revisited: Atherosclerosis in The Post-CANTOS Era
Authors: Koenig Wolfgang ,   Deutsches Herzzentrum München, Technische Universität München, Munich, Germany,   DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich Germany
Published: January 2018

It is fairly well accepted in the scientific community that atherosclerosis carries features of a local and low-grade systemic inflammation. However, it was unclear thus far whether this is simply an epiphenomenon or if it plays a causal role in atherosclerosis and its clinical complications. After several failed attempts, the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS) has provided convincing evidence of interleukin-1 beta as a target whose neutralisation by a selective antibody reduces major cardiovascular events without affecting LDL-cholesterol. This provides strong evidence in support of the inflammation hypothesis and will certainly stimulate research in this area and open the way for novel therapy in high-risk patients following MI.
Análisis comparativo de dos técnicas para el transporte vertical de la luz natural
Authors: Ramírez González Gerardo , Orozco Muñoz Sebastián
Published: January 2018

Este trabajo tiene como objetivo primordial comparar y establecer las relaciones de efectividad entre dos técnicas de diseño para el transporte vertical de la luz natural en el interior de las edificaciones. En primer lugar, se diseñó, construyó y utilizó un equipo experimental tipo concentrador domótico, con distribución a través de fibra óptica hacia un espacio interior sin ninguna iluminación natural tradicional, para monitorizar su efectividad por medio de un luxómetro digital y un recopilador de datos (Datalogger)de entrada múltiple. En segundo lugar, se monitorizó el rendimiento lumínico de un lucernario tradicional durante un periodo de seis meses. Finalmente, se realizó un estudio por medio de la Simulación Generada por Computadora (SGC), para establecer la relación entre las proporciones tridimensionales de los ductos de luz y la tasa de degradación de la iluminancia obtenida en el interior del espacio arquitectónico. En términos de resultados, el sistema de iluminación natural por fibra óptica (SINFO) no alcanza la efectividad lumínica del lucernario, sin embargo, presenta un rendimiento más uniforme y constante. La idea central es utilizar un  criterio de comparación validado, tal como el factor de aprovechamiento de luz diurna (Daylight Factor) y otras métricas complementarias, para establecer una relación básica de efectividad entre ambas técnicas. Por último, se establecen recomendaciones de diseño con relación a la  utilización de cada una de las técnicas.
La alameda: Un estudio de la producción del espacio en Hatillo 8
Authors: Araya Díaz David
Published: January 2018

El presente artículo nace del trabajo final de graduación del autor, en el cual se estudia un sector habitacional de la periferia del centro de San José, conocido como Hatillo 8, como caso paradigmático para comprender algunos elementos arquitectónicos y urbanos característicos de la estructura urbana en Costa Rica. Se explica brevemente el proceso metodológico cualitativo y algunos apuntes teóricos sobre la producción del espacio, las apropiaciones y la propiedad. Posteriormente, se desarrolla la descripción del proceso de producción de la alameda, como ejemplo entre las caracterizacionesrealizadas en el trabajo de graduación. Así, el texto muestra que existen relaciones de poder desiguales que determinan el espacio, las cuales son claramente observables a partir del estudio de Hatillo 8.
Instructivo para la Publicación de Artículos
Authors: UCR REVISTARQUIS
Published: January 2018

Instructivo
Prácticas del liderazgo educativo: Una mirada evolutiva e ilustrativa a partir de sus principales marcos, dimensiones e indicadores más representativos
Authors: Maureira Cabrera Óscar Julio
Published: January 2018

Diversos y múltiples estudios en esta década han destacado consistentemente, en independencia del contexto sociocultural y modalidades de organización escolar, la relevancia que posee el liderazgo en sus diversas acepciones como factor crítico del desarrollo de las instituciones educativas y sus resultados. Orientado por las interrogantes sobre cuáles son las principales prácticas de los enfoques de referencia en liderazgo escolar en estas últimas tres décadas y qué características evolutivas lo han marcado, se presenta este trabajo de revisión, que con base en el análisis de contenido, describe, ilustra y organiza sistemáticamente, por medio de tablas y figuras, una muestra significativa de dimensiones de la práctica del liderazgo con que se le ha identificado en su evolución conceptual. Como resultado de esto, se destaca que a las prácticas del liderazgo directivo individualista y jerárquicas se le han ido agregando características más participativas y colegiadas asociadas a una mayor distribución del poder en las organizaciones escolares.
Vivir y enfrentar la integración/exclusión educativa en el nivel medio superior: estudios de caso en jóvenes de San Luis Potosí, México
Authors: Vilchis Romero Violeta , Arriaga Ornelas José Luis
Published: January 2018

Este artículo aborda la inclusión educativa a partir de las vivencias de jóvenes que poseen una discapacidad física y que han logrado cursar la educación media superior. El enfoque que se ofrece es cualitativo, con estudios de caso y mediante el empleo del método biográfico–narrativo (Moriña, 2010). Esta metodología permite “dar la voz” (Susinos y Parrilla, 2008) a quienes son capaces de señalar con precisión los elementos que impiden su inclusión en los entornos escolares en forma de barreras (Zarb, 1997), pero que también pueden señalar las ayudas que eventualmente les han permitido potenciarse como agentes (Bourdieu, 1997) en el escenario escolar. Los relatos de vida se recuperaron mediante trabajo de campo y fueron contextualizados etnográficamente, con la intención de obtener un panorama más amplio de la experiencia de los sujetos informantes, en el cual aparecen diversos actores que permiten o impiden su participación en la comunidad escolar. El objetivo fue visibilizar y escuchar a quienes regularmente permanecen invisibles y sin voz, para contribuir al incremento de su agencia. El artículo ofrece resultados sobre el tipo de posicionamiento que los sujetos de estudio adoptaron para conseguir su permanencia en las instituciones educativas, pero se pone en duda su real inclusión, pues se asume que esta no se logra, si por lo menos un individuo no se siente bienvenido en la escuela, o si su comunidad escolar no le proporciona múltiples y variadas oportunidades para aprender y participar (Ainscow, 2001).
Mobile gaming and problematic smartphone use: A comparative study between Belgium and Finland
Authors: Lopez-Fernandez Olatz , Männikkö Niko , Kääriäinen Maria , Griffiths Mark D. , Kuss Daria J.
Published: January 2018

Background and aims

Gaming applications have become one of the main entertainment features on smartphones, and this could be potentially problematic in terms of dangerous, prohibited, and dependent use among a minority of individuals. A cross-national study was conducted in Belgium and Finland. The aim was to examine the relationship between gaming on smartphones and self-perceived problematic smartphone use via an online survey to ascertain potential predictors.

Methods

The Short Version of the Problematic Mobile Phone Use Questionnaire (PMPUQ-SV) was administered to a sample comprising 899 participants (30% male; age range: 18–67 years).

Results

Good validity and adequate reliability were confirmed regarding the PMPUQ-SV, especially the dependence subscale, but low prevalence rates were reported in both countries using the scale. Regression analysis showed that downloading, using Facebook, and being stressed contributed to problematic smartphone use. Anxiety emerged as predictor for dependence. Mobile games were used by one-third of the respective populations, but their use did not predict problematic smartphone use. Very few cross-cultural differences were found in relation to gaming through smartphones.

Conclusion

Findings suggest mobile gaming does not appear to be problematic in Belgium and Finland.
Changes in vegetation cover of the Pantanal wetland detected by Vegetation Index: a strategy for conservation
Authors: Miranda Ciomara de Souza , Paranho Filho Antonio Conceição , Pott Arnildo
Published: January 2018

The Brazilian Pantanal wetland undergoes landscape alterations that can cause impacts on hydrological processes, changing the flood pulse. The objective of this work is to analyse the vegetation cover of the Pantanal in the period of 2000, 2008 and 2015, and to make a projection for 2030. Therefore, NDVI from the sensor MODIS was analysed and the transition matrix was calculated by the DINAMICA EGO. The methods adopted were open sources. The results were worrisome, indicating alterations of the vegetation cover of the Pantanal, with an increase of short vegetation (grasslands or pastures) in the evaluated period. The projection pointed out that in 2030 the Brazilian Pantanal wetland area will be covered by 78% of short vegetation and only 14% of dense (arboreal-shrubby) vegetation. The approach can be a useful tool for conservation of the Brazilian Pantanal wetland.
Safety Profile of Biosimilar Filgrastim (Zarzio/Zarxio): A Combined Analysis of Phase III Studies
Authors: Harbeck Nadia , Gascón Pere , Krendyukov Andriy , Hoebel Nadja , Gattu Sreekanth , Blackwell Kimberly
Published: January 2018

Background

Evaluation of adverse events (AEs) in pivotal registration trials and ongoing postmarketing surveillance is important for all biologics, including biosimilars. A combined analysis of two pivotal registration studies was performed to strengthen evidence on safety for biosimilar filgrastim EP2006 in patients with breast cancer receiving myelosuppressive chemotherapy, a sensitive clinical setting to confirm biosimilarity of filgrastim.

Materials and Methods

Data were combined from two phase III studies of biosimilar filgrastim EP2006. The U.S. registration study was a randomized, double-blind comparison of biosimilar and reference filgrastim in women aged ≥18 years with breast cancer, receiving (neo)adjuvant treatment with TAC (docetaxel + doxorubicin + cyclophosphamide). The European Union registration study was a single-arm, open-label study of biosimilar filgrastim in women aged ≥18 years with breast cancer receiving doxorubicin + docetaxel. Patients received filgrastim as a subcutaneous injection on day 2 of each cycle for <14 days or until the absolute neutrophil count reached 10 × 109/L after the expected nadir. Results were combined for cycles 1–4.

Results

A total of 277 patients received biosimilar filgrastim EP2006. Patients had a mean (± standard deviation) age of 51.1 (± 10.8) years, and 78.7% of patients had stage II or III breast cancer. A total of 46 (20.6%) patients receiving biosimilar filgrastim had AEs considered filgrastim-related. The most frequently reported filgrastim-related AEs were musculoskeletal or connective tissue disorders (15.2%), including bone pain (7.2%). One death (due to pulmonary embolism) occurred of a patient receiving biosimilar filgrastim (not considered filgrastim-related). No patient developed antidrug antibodies during the study.

Conclusion

Biosimilar filgrastim has a safety profile consistent with previous filgrastim studies and is effective in preventing febrile neutropenia in patients with breast cancer.

Implications for Practice

The biosimilar filgrastim EP2006 (Zarzio, Zarxio, biosimilar filgrastim-sndz) has been approved in Europe since 2009 and in the U.S. since 2015. This combined analysis of two phase III studies provides additional clinical evidence that the biosimilar filgrastim EP2006 has a safety profile consistent with previous studies of reference filgrastim and supports large postmarketing studies of EP2006 in Europe. Strengthening the evidence for biosimilar filgrastim can help improve acceptance of biosimilars and increase patient access to biologics.
Comparison of site-specific and empirical correlations for drained residual shear strength
Authors: Hayden C. P. , Purchase-Sanborn K. , Dewoolkar M.
Published: January 2018

Analyses of landslides, slopes and embankments often require reliable drained residual shear strength estimates for cohesive deposits involving pre-existing shear surfaces. Laboratory tests to measure residual shear strength can be costly and time consuming. Therefore, empirical correlations based on more readily available index properties such as liquid limit and clay-size fraction appear as an attractive alternative in practice. This paper presents residual strength and index properties for 25 natural samples, predominantly claystone and siltstone, collected from a single geologic setting over an approximately 0·25 km2site. The data show substantial variability in residual strength against any single index parameter considered in a site-specific correlation. Comparisons of these data, along with three additional data sets, generally indicated notable variability among data sets and relatively poor fit to published empirical correlations. Empirical correlations for residual strength may be useful in approximating the expected range of residual strength. However, given the significant variability in the data, both within and between data sets, empirical correlations should not entirely replace carefully performed site-specific laboratory tests measuring residual strength, when reliable values are required.
Construir la interculturalidad. Políticas educativas, diversidad cultural y desigualdad en el Ecuador
Authors: Rodríguez Cruz Marta
Published: January 2018

Junto al discurso de la diferencia, el de la interculturalidad ha pasado a formar parte de la agenda político-pedagógica del Ecuador durante la última década. Con la intención de profundizar el estudio de los usos y abusos de dichos discursos en el ámbito de la educación intercultural bilingüe, se presentan los resultados de una investigación etnográfica cuyo objetivo es analizar hasta qué punto el reconocimiento de la diferencia y la diversidad cultural en las políticas educativas del Estado es correlativo con las prácticas de educación intercultural bilingüe, qué consecuencias tiene sobre la situación de pobreza y desigualdad de la población indígena y en qué medida permite vivir y construir la interculturalidad.
GENDER INEQUALITY IN THE LABOR MARKET OF UKRAINE IN INFORMATION TECHNOLOGIES
Authors: Yefanova I , Martsenyuk T.
Published: January 2018

This article examines the law regulation of the gender equality, and analyzes the phenomenon of gender (in)equalitythe in the labor market in Ukraine in general and IT sphere in particular. Three factors that determine the low level of women participation in the IT sector are being highlighted: structural, organizational, and individual. Aspects of gender segregation in the field of IT in Ukraine are being illustrated by the empirical data gathered from in-depth interviews with female employees of IT companies.
Вопросы изучения покупательского поведения в контексте инноваций в ритейле
Authors: Депутатова Елена Юрьевна
Published: January 2018

Торговля выступает как оплот существования рыночной экономики. Однако то, что покупатели становятся более требовательными и взыскательными не только к качеству товаров, но и обслуживанию, мотивирует менеджмент торговых организаций разрабатывать и внедрять новые формы и методы обслуживания, современные технологии. Являясь одним из направлений сектора рыночной экономики, розничная торговля сегодня выступает не просто как услуга по реализации товаров, но и целое искусство по их представлению с соответствующими культурными, ценностными, образовательными составляющими для покупателя. Крупнейшие операторы сектора потребительских товаров продолжили активное развитие розничных сетей. Важную роль в их успешном существовании определяют инновации. Их внедрение позволяет торговым предприятиям бороться за потребителей и долгосрочность существования на рынке.
Segurança hídrica, adaptação e gênero:
Authors: Nogueira Daniela
Published: January 2018

O presente artigo analisa a contribuição do Programa Um Milhão de Cisternas como estratégia de adaptação para diminuir o impacto da seca na população mais pobre do semiárido brasileiro. Fundamenta-se em estudo de caso apoiado em entrevistas semiestruturadas realizadas em comunidades rurais da Paraíba e Pernambuco. Ao analisar o impacto da perspectiva de gênero presente no programa, bem como das cisternas de captação de água de chuva no cotidiano das famílias, observa-se que políticas de acesso à água com enfoque de gênero resultam em melhores condições de saúde, renda e educação, também potencializando a capacidade adaptativa e contribuindo para diminuir a vulnerabilidade das populações mais frágeis.
O meio ambiente na Índia:
Authors: Santhakumar V.
Published: January 2018

Este ensaio apresenta um levantamento dos principais problemas ambientais da Índia contemporânea eespecula sobre a relação entre a esfera econômica (subdesenvolvimento) e os resultados ambientais. Acontinuação da pobreza e do subdesenvolvimento no país parece ter moldado a natureza dos problemasambientais que a Índia enfrenta. A defecação em locais inapropriados e a queima de biomassa paracozinhar continuam a ser as principais fontes de poluição. Por outro lado, o crescimento econômico daÍndia vem sendo impulsionado pelo setor de serviços e, portanto, a poluição industrial não aumentoua um nível esperado por um país em desenvolvimento, que vem testemunhando um crescimentoeconômico acima de 5% durante as últimas três décadas. O artigo conclui com uma visão sobre apossível relação entre desenvolvimento humano, meio ambiente e possíveis estratégias necessáriaspara o desenvolvimento sustentável.
“Ordenar la provincia”. Sobre el carisma de Néstor Kirchner en Santa Cruz (1991-1996)
Authors: Sosa Pamela
Published: January 2018

En este artículo se reconstruye una de las principales estrategias de representación y fuente de poder del liderazgo de Néstor Kirchner en la provincia de Santa Cruz, Argentina, entre 1991 y 1996: su consolidación de “garante del orden y la estabilidad”. En segundo lugar, se analizan las condiciones sociales que explican el éxito de esta estrategia de representación, en particular su afinidad con un conjunto de atributos sociales de la provincia definidos como parte de la “cultura del sufrimiento” y la capacidad del Frente para la Victoria como organización que encarnaba valores análogos a los comprendidos en la misma. Para cumplir con el objetivo, se utilizaron entrevistas semiestructuradas y análisis de archivos periodísticos.El trabajo es un antecedente en el análisis de las formas de construcción de poder del Frente para la Victoria en sus orígenes, a principios de la década de 1990, en su experiencia previa al acceso al gobierno nacional en 2003.
Heterogeneidad en las microempresas informales mexicanas: evidencia empírica y algunas implicaciones de política
Authors: Rivera Huerta René
Published: January 2018

A diferencia de las teorías tradicionales del desarrollo económico, nuevas corrientes consideran que las microempresas informales en actividades no agropecuarias son un sector dinámico de la economía. No obstante, unas y otras reconocen la necesidad de diseñar políticas destinadas a formalizar estas empresas e incrementar su productividad. Usando datos de microempresas mexicanas para el año 2008 y técnicas de análisis clúster, este artículo propone que, dada la alta heterogeneidad entre las microempresas informales, las políticas a aplicar deben ser distintas. Así, mientras ciertas empresas se beneficiarían de la creación de políticas productivas, otras podrían requerir políticas de asistencia social.
Desplazamiento forzado y adaptación al contexto de destino: el caso de Barranquilla
Authors: Ramos Vidal Ignacio
Published: January 2018

En este artículo se analizan los efectos que el desplazamiento puede generar en a) la estructura de la red de apoyo social de los desplazados, b) en el empleo y c) en variables de implicación comu­nitaria. Se trata de un estudio comparativo en el que se entrevistó a 62 residentes en dos zonas de bajos recursos en Barranquilla, Colombia, de los que la mitad son desplazados. Entre los hallazgos se observó que el análisis de redes egocéntricas evidencia que las personas que trabajan tienen redes más diversificadas geográficamente; que los entrevistados poseen redes densas con alto grado de solapamiento, y que el tiempo de residencia es un factor clave que facilita la identificación con la comunidad y la participación en las iniciativas de desarrollo de esta. Mientras que con el análisis de conglomerados se identificaron dos grupos diferenciados por su nivel de ingreso, por el tiem­po de residencia en la comunidad de destino y por el número de familiares con los que convive.
Christian Laval y Pierre Dardot, Común. Ensayo sobre la revolución en el siglo xxi, Barcelona, Gedisa, 2015, 672 pp.
Authors: Marín Moreno Lina Marcela
Published: January 2018

Acceder al texto completo para consultar el contenido.
Study on Various types of presentations in AIDS patients in Terminal illness
Authors: Bhanoth Balaji Naik , Narukurthi Chakravarti , Dasari Saranya
Published: January 2018

Introduction: After 2-10 years of infection, many patients progress to symptomatic stage, and land with a variety of manifestations depending upon the systems involved and severity of disease and rapidity of immunodeficiency. Hence the present study was under taken to evaluate the various types of clinical presentations of AIDS patients in ‘’terminal stage illness’’.
Materials and Methods: All patients are confirmed cases of HIV / AIDS , with multisystemic involvement and presented with various type of clinical manifestations. Special case proforma was made to record complaints, history, clinical features, investigations, diagnosis and preliminary data was also recorded, for each case separately.
Results: Tuberculosis is the most common presentation among HIV patients in respiratory system. 66% were suffering HIV TB co-infection, 4% were suffering from pneumocystis carnii pneumonia and Bacterial pneumonia each. In relation to Gastrointestinal system, 54% patients had Oro pharyngeal candidiasis, 18% patients had diarrhoea.
Conclusion: Knowing Clinical manifestations of HIV is very essential as because it helps to diagnose and to start accurate treatment. Also aid to study the prevalence of various diseases associated with HIV.
Effect of dihydroartemisinin and its disulphide derivative on biochemical, histological and hematological parameters in rat.
Authors: Etim Emanuel I. , Udoh Imoh E. , Udobang John A. , Usen Iniobong L.
Published: January 2018

Introduction: The disulphide derivative of dihydroartemisinin was synthesized and confirmed of being effective against Plasmodium berghei berghei, some gramme positive bacteria and fungi.
 Objective: The study was designed to compare the effect of the synthesized disulphide derivative of dihydroartemisinin with pure dihydroartemisinin on biochemical, histological and hematological parameters.
 Method: Doses of 10%, 20% and 30% of the LD50 of pure dihydroartemisinin and its disulphide derivatives were orally administered to each group of rat for 14 days. On the 14th day, the rats were sacrificed, and blood collected by cardiac puncture was used for hematological and biochemical studies. The liver and kidney were removed, weighed and preserved in 10% formalin for histopathology studies.
Results: Using Lork’s method, the LD50 for pure dihydroartemisinin was 547.72 mg/kg while the disulfide derivative was 346.41mg/kg. There was a significant difference (p<0.05) in the concentrations of hematological parameters in treated rats from those of the control group. There was a dose dependent increase in the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT)  in the treated groups. The cells of the liver and kidney were slightly affected by all the doses of dihydroartemisinin and moderately by the disulphide derivative.
Conclusion: The toxicity of dihydroartemisinin (DHA) and its disulphide derivative (SDHA) are almost the same, making the SDHA not too toxic for animals. The effect of SDHA on the liver, kidney and hematological parameters are more than those of DHA, however they are within tolerated range. Clinical and therapeutic effectiveness should determine the comparative advantages of the newly synthesized SDHA over DHA and vise versa.
Design for Ephemerality â€“ Idiosyncrasy and Challenges
Authors: Petrova Miroslava
Published: January 2018

Lying at the intersection between architecture, art and design, ephemeral spaces are intentionally developed to exist only for a short period of time, to be destroyed or cease to exist at a given moment. The specific nature of temporary environments requires a different design approach in regard to concept development, choice of materials, constructive solutions, visual perception and spatial experience.The aim of the research is to explore the potential of ephemeral spaces for redefining the architectural boundaries and their heuristic significance for the future development of the design field. Following this objective, the factors for the proliferation of these spaces are studied and a typology in terms of their contextual ephemerality is developed. The research method is based on the structural and semiotic analysis of purposefully selected archetypal examples through which the key characteristics distinguishing ephemeral spaces from permanent ones are discovered. In conclusion, implications on how to teach design students to deal with the inherent dialectics in ephemeral spaces and how to design for ephemerality are discussed. Keywords: Ephemeral spaces, spatial experience, design education.
Effect of Social Relations on Life Quality in Traditional Texture and New Habitats
Authors: Ozturk Sevgi
Published: January 2018

In this study, social life and the status of social relations of individuals living in Hepkebirler District and Inonu District, one that has an extremely traditional texture and the other is one of the new habitat regions in Kastamonu City, respectively, are determined. A 10-question set was asked in the survey with the purpose to investigate the issue. The result of the survey shows that the most positive estimations were â€˜has an intensive populationâ€™ for Inonu District and â€˜being peaceful and tranquilâ€™ for the other. In addition, most negative opinion was that â€˜costs of the residence and rents are cheap in the environment where I liveâ€™ for both districts. However, this condition is more pressing for Inonu District as a new living location. Keywords: Life quality, social structure, Kastamonu.
Message from the Guest Editors
Authors: Matijevic Prof. Dr. Milan
Published: January 2018

It is the great honor for us to edit proceedings of Selected Paper of â€œ 6th International Conference on Education (IC-ED-2017), 29 Juneâ€“1 July 2017, University of Zagreb, Zagreb â€“ Croatia. This privileged scientific event has contributed to the field of educational sciences and research for six years. As the guest editor of this issue, I am glad to see variety of articles focusing on Curriculum and Instruction, Educational Technology ,Educational Administration, Guiding and Counseling, Educational Planning ,Measurement and Evaluation in Education, Learning Psychology ,Developmental Psychology ,Education and Culture ,Instructional Design, Learning and Teaching, Special Education, Distance Education, Life Long Learning, Mathematic Education, Social Sciences Teaching, Science Education, Language Learning and Teaching, Human Resources in Education, Teacher Training,Pre-school Education, Primary School Education, Secondary School Education, Vocational Education, College and Higher Education, Learner Needs in 21 Century, The Role of Education in the Globalization World ,Human Rights Education ,Democracy Education, Innovation and Changing in Education ,New Learning Environments ,Environmental Education, Professional Development ,Creativity ,Nursery Education, Healthy Education ,Sport and Physical Education, Multi-cultural Education ,Mobile Learning, Technology-Based Learning, Music Education, Art Education, History Education, etc.. Furthermore, the conference is getting more international each year, which is an indicator that it is getting worldwide known and recognized. Scholars from all over the world contributed to the conference. Special thanks are to all the reviewers, the members of the international editorial board, the publisher, and those involved in technical processes. We would like to thank all who contributed to in every process to make this issue actualized. A total of 80 full papers or abstracts were submitted for this conference and each paper has been peer reviewed by the reviewers specialized in the related field. At the end of the review process, a total of 26 high quality research papers were selected and accepted for publication. I hope that you will enjoy reading the papers. Best Regards