bluuebunny/crossref_metadata_2025 huggingface dataset:
Modafinil for Narcolepsy: A Systematic Review and Meta-Analysis of Its Effectiveness in Combating Daytime Sleepiness
Authors: Mann Govind Singh , Ramakrishnan Manju , Pakkam Madona L. , Sufiyan Nimra , Kukadiya Romil , Girigosavi Khushal B.
Published: October 2024

Background: Narcolepsy is characterized by excessive daytime sleepiness (EDS) and episodes of cataplexy, frequently triggered by psychological stress, significant disturbances in sleep-wake cycles, pregnancy, or trauma. Modafinil is widely used as the preferred treatment due to its effectiveness in alleviating EDS, improving disease outcomes, and enhancing overall quality of life. Nonetheless, long-term safety and efficacy data are still lacking, underscoring the importance of future research to advance treatment options for narcolepsy. Aim: In our systematic review and meta-analysis, we aim to assess the effectiveness of Modafinil in the treatment of Narcolepsy. Methods: We searched in electronic databases (PubMed, Embase, Google Scholar, Scopus, Science Direct, Web of Science) was performed to identify cohort studies and randomized controlled trials (RCTs) up to 8th July 2024. Data extraction focused on baseline characteristics of the included studies and efficacy outcomes, including scores on the Maintenance of Wakefulness Test (MWT) and Epworth Sleepiness Scale (ESS) . We performed the meta-analysis utilizing the Review Manager software, version 5.4. To assess the outcomes, we compared the Modafinil-treated group with the placebo group, employing the mean difference (MD) and a 95% confidence interval (CI) for statistical analysis. Result: In total, 3833 articles were identified for screening, with nine studies included in the systematic review and five in the meta-analysis. These studies involved 997 adult patients with Narcolepsy treated with Modafinil. MWT revealed a significant increase in total scores (MD= 3.56, 95% CI [2.25 to 4.86], p < 0.00001) and ESS revealed a significant decrease in scores (MD= -3.34, 95% CI [-4.13 to -2.56], p < 0.00001). Conclusion: The research emphasizes the potential of Modafinil in alleviating EDS associated with Narcolepsy. While the results are promising, they are based on short term scale studies. It is crucial to undertake larger-scale, extended-duration, placebo-controlled studies that include a broad range of demographic populations. These trials are essential to confirm the efficacy, verify the safety profile, and fine-tune dosing strategies to maximize the long-term therapeutic benefits.
Graph Neural Network for Daily Supply Chain Problems
Authors: Raul Gonzalez Fabian
Published: October 2024

In this paper, we explore the theoretical foundation of Graph Neural Network (GNN) model and apply it to various traditional supply chain logistics problem. In particular, we study the Route Optimization Problem, Demand Forecasting Problem, Risk Assessment and Anomaly Detection, Supplier Section and Procurement Optimization, Inventory Optimization Problem, and Green Supply Chain Problem. The study helps us the expand the use the GNN and gives daily supply chain management a boost.
Stability and Gas Diffusion: A Theoretical Approach to Evanescence and Permanence in Oxyhydrogen Nanobubbles
Authors: Hernowo A.
Published: October 2024

Nanobubbles, gas-filled entities that possess a size of less than , have notably emerged as critical components within various domains such as environmental science and medicine, primarily due to their remarkable stability and distinctive diffusion characteristics that differentiate them from larger bubbles. This comprehensive study meticulously explores the diffusion rates and stability of hydrogen and oxygen when encapsulated in oxyhydrogen nanobubbles, specifically within aqueous environments, utilizing the Chapman-Enskog theory, which is a well-established framework for understanding gas diffusion processes, alongside a modified Arrhenius equation to effectively evaluate activation volume and stability parameters. The findings from this investigation reveal that the diffusion processes of both gasses experience a significant reduction in rate due to the influence of high internal pressure, as well as the molecular interactions occurring with water, whereby hydrogen is observed to exhibit a marginally accelerated diffusion rate in comparison to oxygen. It is crucial to understand that elements like surface charges, zeta potential, and the idea of activation volume significantly influence the enduring stability of nanobubbles, particularly in specific environmental scenarios that could boost their longevity. These significant findings pose a challenge to classical diffusion models, thereby suggesting a promising potential for the sustained application of nanobubbles in various fields such as water treatment processes and therapeutic medical interventions. Future research endeavors should prioritize the refinement of theoretical models while also aiming to experimentally validate the mechanisms of stability that have been observed across a range of diverse applications to further substantiate these findings.
The Continuum of Filipino Cultural Identity: Balancing Tradition and Change in a Globalized and Post-Pandemic World
Authors: Eslit Edgar
Published: October 2024

As Ambeth Ocampo poignantly states, "The past is not dead; it is not even past." In an era where globalization threatens to homogenize distinct cultural identities, the challenge of preserving the rich tapestry of Filipino cultural heritage becomes paramount. This article investigates the dynamic continuum of Filipino cultural identity, shaped by historical influences and contemporary global interactions. It employs theories of cultural hybridity, transnationalism, and identity to examine the interplay between tradition and modernity, revealing how Filipino culture navigates this complex landscape. Through a detailed analysis of traditional practices, modern adaptations, and the impacts of globalization and the COVID-19 pandemic, the study highlights the resilience and adaptability of Filipino cultural expressions. It further explores intergenerational perspectives on cultural preservation, the role of the diaspora in cultural exchange, and the emergence of new cultural forms in urban settings. By evaluating ongoing efforts to celebrate and preserve Filipino heritage, this paper emphasizes the necessity of recognizing both historical roots and contemporary realities. Ultimately, it issues a call to action for a collective commitment to the celebration and preservation of Filipino cultural heritage, underscoring its vital role in fostering identity and community in an increasingly interconnected world.
Increasing Silicate Supply with Decreasing Npk Fertilization Can Mitigate the Stimulative Effect of Shading on Carbon Intensity in Paddy Field
Authors: Lou Yunsheng , Wang Kun , Xing Yuyuan , Liu Jian , Ren Lixuan
Published: October 2024

Decreased solar radiation is one of the main issues of climate change. Decreased solar radiation reduced rice yield, while compound fertilization with silicate enhanced the yield. However, it is not fully understood regarding the fertilization effects on the yield, the emissions of methane (CH4) and nitrous oxide in paddy fields under decreased solar radiation. Field simulation experiments with shading were conducted in two consecutive years (2019 to 2020) at the Agrometeorological Station, Nanjing, China. An orthogonal experimental design with three factors and three levels was adopted in this study. The shading was set at 3 levels, i.e. no shading (S0), shading from flowering to maturity period (S1), and shading from tillering to maturity period (S2), with 64% of shading rate. The compound fertilization (as NPK) was set at 3 rates, i.e. 100 kghm-2 (F1), 200 kghm-2 (F2), and 300 kghm-2 (F3). The silicate supply was set at 3 levels, i.e. no silicate supply (R0), adding steel slag at 200 kg SiO2hm-2 (R1), and adding steel slag at 400 kg SiO2hm-2 (R2). The results showed that, shading significantly reduced rice yield. Compared with S0, S1 and S2 significantly decreased rice yield by 43.31-43.32% and 48.51-48.52%, respectively. Shading extremely reduced the cumulative CH4 emission. Compared with S0, S1 and S2 decreased the cumulative CH4 emission by 7.47%-15.21 and 52.15-57.72, but increased the cumulative N2O emission by 8.56%-26.25% and 54.80-57.59%, respectively. The compound fertilization significantly increased the cumulative CH4 and N2O emissions. Compared with F1, F2 and F3 increased the cumulative CH4 emission by 42.01-48.29% and 9.59-57.00%; and enhanced the cumulative N2O emission by 5.67-85.81% and 21.32-192.98%, respectively. Compared with control (R0), silicate supply generally decreased the cumulative CH4 emission by 20.1%-29.57, while increased the cumulative N2O emission by 8.58%-39.57% and 9.12%-48.00%, respectively. Shading (S1 and S2) decreased the total global warming potential (GWP) by 6.88%-13.69% and 47.58%-55.73%, while compound fertilization increased the total GWP by 43.91-49.05% and 10.36-59.70%, respectively. In general, shading and compound fertilization increased the greenhouse gas emission intensity (GHGI) by 59.51%-60.62% and 33.13%-105.76%, while silicate application decreased the GHGI by 23.08%-50.50%, respectively. This study suggests that, controlling the fertilization amount was helpful in decreasing the GHGI, simultaneously ensuring rice yield under decreased solar radiation, with the optimal fertilization at 100 kg·hm-2 of compound fertilizer (as NPK) and 200 kg SiO2·hm-2 of steel slag in the lower reaches of Yangtze River, China.
Thermal Deformation Behavior and Consitutive Equation of Uranium-50wt.%Zirconium Nuclear Fuel
Authors: Li Yanfeng , Hong Guo , Mingyang Li , Bingkun Hu , Jiancheng Liu
Published: October 2024

In order to study the thermal deformation behavior of uranium-50wt.%zirconium, used Gleeble 3800 thermal simulation testing machine to carry out compression deformation experiments at different temperatures for this material. The effects of deformation temperature and strain rate on the alloy were studied. The results show that the peak stress of U-50wt.%Zr metallic fuel decreases with the increase of deformation temperature after thermal deformation at 500°C~600°C, especially at 600°C compared with that at 500°C and 550°C. At the same temperature, the peak stress increases with the increase of strain rate, especially the peak stress at strain rate 0.1s-1 and 1s-1 is significantly higher than that at strain rate 0.01s-1, and then the microstructure and diffraction results of U-50wt.%Zr metal-type fuel after thermal deformation are compared and analyzed, and the Arrhenius-type constitutive equation and thermal proces550℃,έ=1s-1 diagram of U-50wt.%Zr metal-type fuel are established based on the peak stress.
COVID-19 Vaccinations, Infections and Outcomes among 784 People Living with HIV
Authors: Mahlab-Guri Keren , Komarova Irina , Kadar Laliv , Nemet Shay , Cohen Ramon , Radian-Sade Sara , Tova Achiel , Guri Alex , Bezalel-Rosenberg Shira , Elbirt Daniel
Published: October 2024

Introduction: Variants of COVID-19 are responsible for 700 million infections and 7 million deaths worldwide. Vaccinations have high efficiency in preventing infection and secondary benefits of reducing COVID-19 hospital admissions, attenuating disease severity and duration of illness. Conflicting reports were published regarding COVID-19 among PLWH. Objective: The aim of this study was to evaluate COVID-19 morbidity, hospitalization and the magnitude of immunological response to sequential BNT 162b2 mRNA vaccines in PLWH regarding demographic and clinical factors. Results: Our retrospective study included 784 PLWH who had at least one anti- SARS-CoV-2 antibody test between March 2021 and October 2021. Half of our patients (392) had CD4 cells count above 500 cells/µl, 40.2% (315) had 200<CD4<500 cells/µL and only 9.8% (77) had CD4 <200 cells/µL at their last laboratory workup. The mean age was 50.2±12.2 years. About 90% of our patients were given at least two doses of the BNT 1626b2 Pfizer vaccines, about 60% received three doses of the vaccine. About a quarter of our patients (27.3%) had COVID-19 infection. Only 6 patients required hospital admission. All six patients recovered from COVID-19 infection. Titers of COVID-19 antibodies were lower for patients with CD4 cells count of less than 200 cells/ µL in the first, second and third serological tests with statistical significance. In a multinomial logistic regression the influence of other factors such as age, sex, previous COVID-19 infection on first COVID-19 antibodies titers was not significant. Conclusions: PLWH are responsive to COVID-19 vaccines. As was expected, patients with higher CD4 cells count have higher titers of COVID-19 antibodies and less severe illness. Age, sex and previous COVID-19 infection did not significantly affect antibodies titers according to our study. Larger prospective studies with control groups are needed to further characterize immunologic response to COVID-19 vaccination among PLWH.
The Synergistic Effect of Intradialytic Concurrent Training and Melatonin Supplementation on Oxidative Stress and Inflammation in Hemodialysis Patients: A Double-Blind Randomized Controlled Trial
Authors: Marzougui Houssem , Ben Dhia Imen , Mezghani Ines , Maaloul Rami , Toumi Salma , Kammoun Khawla , Chaabouni Mohamed Nejib , Ayadi Fatma , Ben Hmida Mohamed , Turki Mouna , Hammouda Omar
Published: October 2024

Background: This study aimed to investigate the effects of intradialytic concurrent (resistance-endurance) training combined with melatonin (MEL) supplementation on oxidative stress, inflammation, and cellular damage in hemodialysis (HD) patients. Methods: Thirty-two hemodialysis (HD) patients were randomly assigned to three groups: Exercise (EX)-MEL, EX-Placebo (PLA), and Control (C)-PLA. Participants in the EX-MEL and EX-PLA groups underwent 12 weeks of concurrent training. Before nocturnal sleep, they ingested either 3 mg of MEL (EX-MEL) or a placebo (EX-PLA and C-PLA). Blood samples were collected at baseline and after 12 weeks of intervention to assess lipid peroxidation [malondialdehyde (MDA)], antioxidant biomarkers [ferric reducing antioxidant power (FRAP), reduced glutathione (GSH), total thiol (THIOL)], total bilirubin (TBIL), uric acid (UA), biomarkers of muscle and liver damage [aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT), creatine kinase (CK), lactate dehydrogenase (LDH), Gamma-glutamyltransferase (Gamma-GT)], and inflammation [C-reactive protein (CRP)]. Results: EX-MEL demonstrated a decrease of MDA (p
Questioning the Lorentz Factor in Special Relativity Based on the Value of the Maximum Anisotropy of Light Speed in the Michelson-Morley Experiment
Authors: yu yunrui
Published: October 2024

Newton's classical dynamics accurately describes the motion of objects moving at speeds much less than the speed of light and has been extensively validated under these conditions. Any new dynamics formula must reduce to Newton's equations at low velocities. Einstein's theory of special relativity, which utilizes the Lorentz factor, provides a revised view of space-time and also conforms to Newton's equations for low speeds. However, the Lorentz factor assumes that the maximum anisotropy of the speed of light is zero, a condition not fully supported by experimental evidence. The Michelson-Morley Experiment, conducted at a speed far less than that of light, suggests that while the measured anisotropy is very small, it is not zero. This small value could imply the existence of undiscovered physical laws. To address this, we propose the Yuyunrui factor, which includes two hyperparameters, \(\alpha\) and \(\beta\), encompassing various possible models. In this framework, the Lorentz factor represents a special case with \((\alpha=0, \beta=1)\) and zero anisotropy. We categorize the \((\alpha, \beta)\) combinations into four broad types based on their scaling effects and describe these in detail. Future experiments at higher speeds will be essential to accurately determine the true value of the maximum anisotropy of the speed of light and to refine the proposed factor.
Genome-Wide Identification and Expression Analysis of the Melon ALDH Gene Family in Response to Abiotic and Biotic Stresses
Authors: Yang Dekun , Chen Hongli , Zhang Yu , Wang Yan , Zhai Yongqi , Xu Gang , Ding Qiangqiang , Wang Mingxia , Zhang Qi-an , Lu Xiaomin , Yan Congsheng
Published: October 2024

Through the integration of genomic information, transcriptome sequencing data, and bioinformatics methods, we conducted a comprehensive identification of the ALDH gene family in melon. We explored the impact of this gene family on melon growth, development, and their expression patterns in various tissues and under different stress conditions. Our study discovered a total of 17 ALDH genes spread across chromosomes 1, 2, 3, 4, 5, 7, 8, 11, and 12 in the melon genome. Through a phylogenetic analysis, these genes were classified into 10 distinct subfamilies. Notably, genes within the same subfamily exhibited consistent gene structures and conserved motifs. Our study discovered a pair of fragment repeats within the melon ALDH gene. Furthermore, there was a noticeable collinearity relationship between the melon's ALDH gene and that of Arabidopsis (12 times), and rice (3 times). Transcriptome data reanalysis revealed that some ALDH genes consistently expressed highly across all tissues and developmental stages, while others were tissue or stage-specific. We analysed the ALDH gene's expression patterns under six stress types, namely salt, chilling, waterlogged, powdery mildew, fusarium wilt, and gummy stem blight. The results showed differential expression of MELO3C024328 and MELO3C004430 under all stress conditions, signifying their crucial roles in melon growth and stress response. RT-qPCR analysis further corroborated these findings. This study paves the way for future genetic improvements in melon molecular breeding.
Towards the Implementation and Integration of a Digital Twin in a Discrete Manufacturing Context
Authors: Lanzini Michela , Ferretti Ivan , Zanoni Simone
Published: October 2024

In the context of enhanced decision-making related to Industry 4.0 and 5.0, this work examines the first step to implement a Digital Twin (DT) in a discrete manufacturing firm. The DT will be required to be adequately integrated with the information systems, especially the Manufacturing Execution System (MES), because the virtual counterpart of the DT itself, a Discrete Event Simulator (DES) model, will exploit MES data for the validation and the monitoring. The objective of the DT is to enhance the decision-making related to production planning, in particular, achieving better on-time delivery to customers. Therefore, the DT intends to depict material flows within the production department to enhance monitoring and control, facilitating the prompt identification of deviations from the plan, and supporting the decision-makers, enabling a more responsive and informed management of delay alerts. The first goal to achieve the DT implementation and integration is to establish a conceptual framework that improves material flow data synchronization. A conceptual integration and implementation framework for the DT will be proposed and discussed, underlying the technical decisions chosen to achieve the functional and integration requirements.
Challenges and Security Risks in the Red Sea: Impact of Houthi Attacks on Maritime Traffic
Authors: Rodriguez-Diaz E. , Alcaide Juan Ignacio , Garcia-Llave R.
Published: October 2024

This study delves into the significant impact of Houthi insurgent activities on maritime traffic within the strategic Red Sea and Suez Canal routes, crucial conduits for global trade. It explores the correlation between regional instability, as exemplified by Houthi actions from 1st attack to a merchant vessel (November 19, 2023) to February 5, 2024, and alterations in maritime traffic patterns, alongside the operational efficiency of these vital maritime arteries. Employing descriptive statistics, qualitative, and geospatial analytical methods, the research examines recent trends in maritime traffic and incident reports, shedding light on the spatial and geopolitical challenges faced by one of the world's most critical trade routes. The findings reveal a marked decline in maritime activity in the Gulf of Aden and Suez Canal, attributed to security concerns stemming from Houthi attacks, with a significant shift towards alternative routes, notably around the Cape of Good Hope. This shift underscores the broader implications of regional instability on global trade dynamics and the critical nature of maintaining uninterrupted maritime flow. The study also highlights the economic ramifications, including increased operational costs and freight rates due to longer transit times and enhanced security measures. It concludes with a call for improved maritime security protocols and international cooperation to safeguard these strategic maritime pathways. This research contributes to the discourse on transport geography by quantifying the direct impacts of regional conflicts on maritime logistics and proposing strategies for future resilience, emphasizing the intertwined nature of global trade, security, and the urgent need for collective action in the face of evolving geopolitical challenges.
Association of Oral Tobacco-Free Nicotine Delivery Product with Acute Renal Tubular Necrosis
Authors: Acharya Ratna , Clapp William L , Upadhyay Kiran
Published: October 2024

Usage of novel non-tobacco oral nicotine delivery products (ONDP) has been increasing among adolescents in the United States. It is presumed that they are less toxic than their tobacco containing counterparts, but that has not been examined in controlled studies. Most of the studies have focused on non-renal manifestations of tobacco consumption via different means. The renal manifestations of non-tobacco ONDPs are not very well known, especially in immunocompromised patients. Here, we describe a 19-year-old adolescent with kidney transplant who sustained acute tubular necrosis leading to advanced chronic disease apparently following the usage of non-tobacco ONDP. Further larger studies are needed to study the renal manifestations of these next generation products to raise awareness among public.
Thermal Stress in Outdoor Spaces during Mediterranean Heatwaves: A PET and UTCI Analysis of Different Demographics
Authors: TOUSI EVGENIA , MELA ATHINA , TSELIOU ARETI
Published: October 2024

Urban public space comfort is vital for enhancing the quality of life and perceptions of livability, especially as climate change increasingly impacts outdoor thermal environments. This study investigates the use of ENVI-met, a 3D microclimate simulation tool, to assess thermal comfort concerning demographic factors like age and gender. While ENVI-met is often used to analyze urban microclimates, there is limited research on its application for simulating heat emission variations across different demographic groups. The findings highlight significant disparities in thermal stress vulnerability: elderly individuals are at higher risk due to elevated maximum PET values, while children experience broader ranges of thermal stress and higher baseline values. Despite cooling effects in the evening, children continue to face greater stress. The study emphasizes the need for tailored management strategies, as morning PET values are consistent but afternoon data reveals children’s ongoing vulnerability. Overall, the research calls for further investigation to enhance urban planning, thermal comfort strategies, and public health interventions amid rising temperatures. It advocates for expanding ENVI-met's capabilities to include diverse demographic factors, promoting a more comprehensive approach to urban resilience and well-being.
The Evolution of Dilatant Shear Bands in High Pressure Die Casting for Al-Si Alloy
Authors: LU JINGZHOU , lordan ewan , Dou Kun
Published: October 2024

Bands of interdendritic porosity and positive macrosegregation are commonly observed in pressure die castings, with previous studies demonstrating their close relation to dilatant shear bands in granular materials. Despite recent technological developments, the micromechanism governing dilatancy in the high pressure die casting (HPDC) process for alloys between liquidus and solidus temperature region is still not fully understood. To investigate the influence of fluid flow and the size of externally solidified crystals (ESCs) on the evolution of dilatant shear bands in HPDC, various filling velocities were trialled to produce HPDC samples of Al8SiMnMg alloy. This study demonstrates that crystal fragmentation is accompanied by a decrease in dilatational concentration, thus producing an indistinct shear band. Once crystal fragmentation stagnates, the enhanced deformation rate associated with a further increase in filling velocity (from 2.2 ms-1 to 4.6 ms-1) localises dilatancy into a highly concentrated shear band. The optimal piston velocity is 3.6 ms-1, under which the average ESC size reaches the minimum and the average yield stress and overall product of strength and elongation reaches the maximum value of 144.6 MPa and 3.664 GPa%, respectively. By adopting the concept of force chain buckling in granular media, the evolution of dilatant shear bands in equiaxed solidifying alloys can be adequately explained based on further verification with DEM-type modelling in OpenFOAM. Three mechanisms for ESC enhanced dilation are presented, elucidating previous reports relating the presence of ESCs to the subsequent shear band characteristics. By applying the physics of granular materials to equiaxed solidifying alloys, unique opportunities are presented for process optimization and microstructural modelling in HPDC.
Hardware-Software Compatibility in Robotic Cyber-Physical Systems – an Application Based Approach
Authors: Penar Paweł , Szeremeta Mateusz , Gola Arkadiusz
Published: October 2024

The sciences related to production engineering consider many aspects related to cyber physical systems (CPS), in particular robots, treating them as implementations of the Industry 4.0 con-cept. The construction of CPS remains the domain of various engineering disciplines - mechan-ics, control theory or computer science. The problem of communication occurring during the implementation of the control of a single robot understood as a CPS object may concern the ex-change of data within a CPS or between different CPSs. In this area, software and hardware compatibility problems arise. Therefore, the paper presents a modular application for the ex-change of process data between mechatronic devices such as robots, which solves this problem. The work is complemented by an example of the use of the presented application in communi-cation between a mobile wheeled robot with Macanum wheels and a quadruped robot based on a motion capture system. It was assumed that the control of the wheeled robot would be realized from the perspective of implementing the basic robotics task of driving to a target, while the quadruped robot, representing a moving target, together with the motion capture system, would constitute a CPS whose outputs are incompatible in a software and hardware sense. With this choice of example, main attention was focused on the particular importance of multidisci-plinary in the context of the communication problem and also provide an application that al-lows for a modular solution to the problem of software/hardware compatibility in the commu-nication problem. This, in turn, is of interest to researchers associated with various engineering disciplines.
A Fusion Navigation System of Security Robot Based on Millimeter Wave Radar and Inertial Sensor
Authors: Zheng Rui , Sun Geng , Li Fang Dong
Published: October 2024

In smog and dust environments, vision and laser-based navigation methods can not be used effectively for controlling the movement of a robot. Autonomous operation of a security robot can be achieved in such environments by using millimeter wave (MMW) radar for the navigation system. In this study, an approximate center method under sparse point cloud is proposed, and a security robot navigation system based on millimeter wave radar is constructed. To improve the navigation accuracy of the robot, inertial navigation of the robot is integrated with MMW radar. Based on the concept of inertial navigation, the state equation for the motion principle of the robot is deduced. According to principle of MMW navigation, the measurement equation is derived, and the kinematics model of the robot is constructed. Further, by applying the Kalman filtering algorithm, a fusion navigation system of the robot based on MMW and inertial navigation is proposed. The experimental results show that the navigation error is close to the error of the navigation system with only MMW in the initial stage. With iterations of the filtering algorithm, the gain matrix converges gradually, and the error of the fusion navigation system decreases, leading to the stable operation of the robot. The localization error of the fusion navigation system is approximately 0.08 metre, and the navigation accuracy is better than that of the navigation system with only MMW radar.
Muli-Agent AI Systems in Healthcare: Technical and Clinical Analysis
Authors: Borkowski Andrew , Ben-Ari Alon
Published: October 2024

Scaling the operation is the single greatest challenge in every enterprise. The more complex the enterprise, the greater the challenge. Scaling in healthcare has been a consistent challenge, with the need to meet clinical endpoints with less staff, increased costs of resources, regulatory oversight, and the goal of improving access to care. The article explores the emerging paradigm of multi-agent AI systems in healthcare, representing a significant leap beyond traditional Large Language Models. We comprehensively analyze the potential of these systems to revolutionize patient care, streamline administrative processes, and support complex clinical decision-making. The paper describes a hypothetical sepsis management system comprising seven specialized AI agents, each handling specific aspects of patient care, from data collection and diagnosis to treatment recommendations and resource management. We also examine applications in chronic disease management and hospital patient flow optimization. The technical implementation of these systems is discussed, including the use of advanced Large Language Models, inter-agent quality control measures, implementing guardrails, self-reflection, integration with Electronic Health Records, and the importance of explainable AI for decision transparency. In addition to describing the promising potential benefits, such as enhanced diagnostic accuracy and personalized treatment plans, we address significant challenges, including data quality assurance, workflow integration, and ethical considerations. We conclude the article by highlighting future directions, such as integrating IoT devices and developing more sophisticated natural language interfaces. Our work underscores the transformative potential of multi-agent AI systems in healthcare while emphasizing the need for rigorous validation, ethical oversight, and a patient-centered approach in their development and implementation.
Research on Neonatal Conditions in Africa: Volume, Impact, Thematic Spectrum, and Collaboration from a Bibliometric Perspective
Authors: Vieira Elizabeth
Published: October 2024

The literature has addressed the negative impact of poor neonatal conditions (NC) across regions. This has drawn attention to the need to improve NC, particularly in Africa. NC research can make an important contribution. However, there is no study dedicated to this topic in Africa. Through a bibliometric analysis, we arrive at outputs that can inform scientists in planning ongoing or new NC research and those involved in developing and implementing strategies to combat poor NC. Using bibliometrics, the study identified the scientific knowledge on NC between 2000 and 2019, its visibility in the community, the main topics researched, and collaboration patterns.The results show that knowledge on NC has increased between 2000 and 2019, it is concentrated in a few African countries (Egypt, South Africa, Nigeria, Tanzania and Kenya), its visibility is below the world average, in general, maternal mortality is the most researched topic and collaborative activities are frequently, mainly international research collaboration (IRC), being the United States of America (USA) and the United Kingdom (UK) the main partners (they participated in 57% and 28% of all articles with IRC). The collaboration networks are fragile as 43%-67% of all links represent one article in 20 years.Ongoing or new research on NC in Africa should consider the main African players and their partners. There is a need to implement strategies to increase NC knowledge in other African countries, expand and strengthen the collaboration networks and diversify the sources of knowledge.
Computer vision. Laboratory practic
Authors: Ageev Aleksey Vladimirovich , Boguslavskiy Andrey Alexandrovich , Vlasov Sergei Olegovich , Sokolov Sergey Mikhailovich
Published: October 2024

A methodological guide for the introduction to the subject "Computer vision". The basic concepts and algorithms are considered from a theoretical point of view, as well as practical tasks for the development of image processing programs for technical vision system are presented.
The Effect of Variation Concentration of Simplex Syrup on the Physicochemical Stability of Nanosilver Syrup
Authors: Ermawati Dian Eka , Hanuriansyah Yavi , Susanto Nindita Clourisa Amaris , Rochmani Sholichah , Utami Diyah Tri , Zulpadly M. Fiqri , Sasongko Heru , Darojati Ulfa Afrinurfadhilah , Meitasari Annisa Diyan , Untari Meta Kartika
Published: October 2024

Inulin from Gembili has been identified as an effective bioreductor for forming nanosilver with a size of 481.4 nm, stable for 30 days when stored at 4°C. Inulin nanosilver exhibits immunomodulatory properties and has been proven safe through acute toxicity evaluation at a dose of 4 mg/kgBB. A drug delivery system needs to be developed for its use as a supplement. Syrup was chosen due to its alcohol-free nature, better taste, and ease of measuring the active substance compared to elixirs, solutions, and suspensions. Simplex syrupus, used as a syrup base, influences stability by potentially forming crystals during storage. This research aims to determine how varying concentrations of simplex syrupus affect the physicochemical properties of inulin nanosilver syrup. The study involved the biosynthesis process using Gembili's inulin, nanosilver characterization, formulation, and stability testing. Inulin nanosilver syrup was prepared with simplex syrupus concentrations of 20%, 40%, and 60%. The physicochemical stability of the syrup, including organoleptic properties, pH, and viscosity, was tested before and after storage at 4°C and 40°C over six cycles. The selected formula was evaluated for sugar reduction content and FT-IR profile. Data analysis was performed using SPSS 21.0 for Windows with One-way ANOVA and Paired T-Test. Results indicated that higher concentrations of simplex syrupus led to increased consistency, pH, and viscosity. A 60% concentration of simplex syrupus met the physicochemical stability requirements, with a medium-thick consistency, pH of 5.25±0.03, and viscosity of 92±2.6 cps. The reducing sugar content was 20.59% ±0.002, and the FT-IR profile confirmed the presence of inulin nanosilver, indicated by Ag-N groups compared to silver nitrate solution. This product has the potential to be developed as a health supplement.
Development of PBL-Based Chemistry E-Modules for Colloidal Systems
Authors: Sari Sri Adelila , Nasution Nurfadillah Syam
Published: October 2024

Integrating digital learning tools has become increasingly important for enhancing student engagement and learning outcomes in the rapidly evolving educational landscape. This research aimed to assess the feasibility of a developed e-module and its impact on student learning outcomes. The development process followed the ADDIE Model, comprising five stages: Analysis, Design, Development, Implementation, and Evaluation. The instruments used included interview sheets, e-module validation sheets, student response questionnaires, and a 20-item test instrument. The e-module was validated by experts based on content, presentation, language, and graphic criteria, achieving an average validity score of 91.6%, indicating strong validity. Following validation, the e-module was implemented with 36 eleventh-grade Science Program (XI MIA) students at a high Islamic school in Medan during the 2023/2024 academic year. The results demonstrated a significant improvement in student learning outcomes, as evidenced by an N-gain score of 0.76, which falls within the high criteria. Additionally, student responses to the e-module were overwhelmingly positive, with an average approval rating of 87%, categorising their feedback as "very good." The findings suggest that the developed e-module is feasible and effective in enhancing student learning outcomes. The high validation scores and positive student feedback indicate that the e-module is well-designed and meets educational standards. It is a valuable tool for improving student engagement and achievement in the classroom.
Non-Enzymatic Detection of Glucose and Ketones in Urine using Paper-Based Analytical Devices
Authors: 'Aisy Kamila Rohadatul , Fahmi Ahmad Luthfi , Sulistyarti Hermin , Wulandari Ika Oktavia , Sabarudin Akhmad
Published: October 2024

Diabetes, driven by unbalanced diets and unhealthy lifestyles, is highly prevalent. In Indonesia, its prevalence is projected to reach 28.6 million by 2045. Microfluidic paper-based analytical devices (μPADs) are paper-based analytical tools that use hydrophilic paper for measurement and hydrophobic barriers to control fluid flow. This research aims to develop a non-enzymatic method for detecting glucose and ketones in artificial urine using S2Z-μPADs. The fabrication of S2Z-μPADs involves printing the design on Whatman No. 1 paper using wax printing and applying silver nanoparticles for glucose detection and the Schiff base reaction for ketone detection. The results show that the optimum condition for glucose detection is achieved with an AgNO3 concentration of 500 mM. A NaOH concentration of 10 M. Acetoacetate detection is optimized with a glycine concentration of 1 M, sodium nitroprusside concentration of 15%, NaOH concentration of 1 M, a drying time of 8 minutes, and a reaction time of 10 minutes. Validation results demonstrate good linearity for glucose (R² = 0.9821) and ketones (R² = 0.995). High precision was achieved with relative standard deviation (RSD) values of 3.792% for glucose and 1.482% for ketones. The obtained limits of detection (LOD) and limits of quantification (LOQ) indicate that the developed S2Z-μPADs can differentiate between each category of diabetes. The accuracy of glucose and ketone detection ranges from 87.463% to 97.374%. The high accuracy of the μPADs highlights their potential for reliable diabetes management and effective disease monitoring.
Ña - (Sol)
Authors: Reza Albañez Juana Inés
Published: October 2024

Fragmento: Yo vengo de donde nace el sol, dicen mis ancestros que somos lo que concibió la primera mujer que fue inseminada por el sol y gotas de agua de manantial que hizo a la gente Pa Ipai. Miabkiak el gran creador acomodó a las personas en sus territorios, las grandes aguas del rio son testigo del canto que hizo dios para acomodar los clanes en las tierras que serían su hogar, nombrando a cada pueblo y nombró al Jaspuy paim Pa Ipai dándole la tierra que se llama xajtubjool agua caudalosa, donde se mete el sol.
Semblanza
Authors: Vivanco Olivia
Published: October 2024

Ha exhibido su trabajo en el Museo Carrillo Gil, Museo Universitario del Chopo, Centro de la Imagen, Centro Cultural de Espa.a, y la Alianza Francesa de M´éxico entre otros. En Alemania, Colombia, Chile, Dinamarca, España, Estados Unidos, Francia, Marruecos y Puerto Rico.
Referente curricular de la educación inicial Chilena: su respuesta a la interculturalidad
Authors: Flores-Meza Giannina , Garrido-González Lorena
Published: October 2024

En la actualidad uno de los grandes temas en educación es la interculturalidad y como esta se ha hecho presente en ella, así también la forma en que la educación está dado respuesta a la diversidad étnica, cultural, religiosa, como otras existente entre niños, niñas y estudiantes que conviven día a día en establecimientos que entregan educación. Esta es una preocupación no solo de un sector, es una inquietud desde el primer nivel educativo chileno.
Reflexiones sobre la migración en Chile y la educación superior
Authors: Gómez-Vilches Bárbara
Published: October 2024

Es por eso que se plantea como objetivo de este artículo, proponer una mirada crítica de las políticas migratorias y educativas que hay en Chile con relación a las posibilidades que tienen las y los jóvenes migrantes para acceder y financiar sus estudios superiores y cómo el Programa de Acceso a la Educación Superior (PACE), que ministerialmente están mandatados a restituir el ingreso a la educación superior mediante un cupo supernumerario de las instituciones superiores, se ven condicionados por las políticas existentes y las y los estudiantes migrantes quedan sin ningún tipo de solución al respecto.
¿Qué nos sugiere pensar la educación inclusiva en términos de teorización crítica?
Authors: Ocampo González Aldo
Published: October 2024

Uno de los primeros atributos analíticos que debiesen ser discutidos aquí, es la idea de lo ‘inclusivo’ al interior del sintagma educación inclusiva. Tal tarea crítica exige comprender los sistemas de enmarcamiento de sus desempeños epistemológicos que convergen en torno al significante de lo inclusivo.
Modelo de educación inclusiva: enfoque de derechos para todos los niveles educativos
Authors: Delgado Valdivieso Karina , Ocampo Gonzáles Aldo
Published: October 2024

La educación inclusiva hoy en día debe analizarse y aplicarse en todos los niveles educativos. Resulta de gran importancia conocer aquellas acciones vinculadas a hacer un trabajo que oriente a los niveles de educación inicial, media y superior.
Molecular docking of Portulaca oleracea L. alkaloid compounds for potential antidiabetic activity through Cdk5 protein expression
Authors: Arfan Alya , Rahman Habibi Alif
Published: October 2024

Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine protein kinase, which forms the p35 or p39 active complex that is expressed predominantly in neurons. Cdk5 plays an important role in physiological functions in non-neural cells such as glucose-stimulated insulin secretion in pancreatic cells. This study aims to explore and determine the effectiveness of the chemical compound Oleracein E (OL-E) in the Portulaca oleracea (PO) as an anti- diabetic when expressed on Cdk5 protein. The test was carried out in silico with a computer- aided drug design method in which the molecular docking process used software such as Pyrx 0.8. The results of this study indicate that OL-E has the potential as an antidiabetic by inhibiting Cdk5 and has 27.65% better effectiveness than metformin in inhibiting Cdk5.
Entrepreneurship Education and Self-Efficacy: How Do They Affect the Entrepreneurial Readiness of Vocational Students?
Authors: Widati Sekar Tri , Siti Neno Muawiyah  , Suparno
Published: October 2024

The dearth of entrepreneurial activity in Indonesia can be attributed to the lack of requisite skills possessed by those who aspire to become entrepreneurs. It is evident that aspiring entrepreneurs lack the necessary skills to play an effective role in the country's economy. Consequently, it is of the utmost importance to implement tangible measures with the objective of enhancing the country's economic performance. In addition, it is essential to implement concrete measures with the aim of improving entrepreneurial skills among the population. One potential avenue for improvement is through educational initiatives that impart the requisite skills. The objective of this study is to assess the influence of entrepreneurial readiness on students from an early age. This study examines the effect of entrepreneurship education and self-efficacy on the entrepreneurial readiness of vocational students. The data utilized in this study were collected from primary sources. The data were processed using the structural equation modeling (SEM) partial least squares (PLS) version 4.0.2 application. The SEM-PLS Version 4.0.2 application demonstrated that entrepreneurship education has a significant effect on entrepreneurial intention. The findings indicate that entrepreneurship education plays a pivotal role in fostering vocational students' readiness for entrepreneurship. The study found that self-efficacy has a significant effect on vocational students' readiness for entrepreneurship. Furthermore, the results indicated that entrepreneurship education
Analysis of the Implementation of Standard Operating Procedures in Archives Management at PT Pelabuhan Indonesia (Persero)
Authors: Fadiah Septi Ainun , Marsofiyati  , Ervina Maulida
Published: October 2024

This research was motivated by the application of Standard Operating Procedures (SOP) for archive management which was not yet effective when the researcher carried out practical field work activities carried out by employees. The aim of the research is to find out how the records management system works, how the records management SOP is implemented and how the effects of the records management SOP are implemented. This research uses a qualitative approach using observation, interviews and documentation methods. The data used in this research is primary data, namely data collected directly by researchers. Phenomenally, based on field observations, we see that space infrastructure is increasingly lacking in space, this is due to the increasing volume of archives. Meanwhile, during observations of archive sorting activities, several other practitioners felt confused about categorizing letters/documents that would be archived by different work units. With the Standard Operating Procedure indicators for archives, the application of SOPs to archive management and the influence of the application of SOPs to archive management. The results of this research conclude that the records management system is running well and in accordance with the applicable SOPs as its implementation is running well and even has a good impact on employee performance. Not only that, in terms of perceived obstacles, we also have good solutions to continually improve employee performance. This is one of the best steps in implementing records management in companies.
Audit Tools and Linked Archive System (ATLAS) in the Process of Preparing Audit Working Papers: Approach with the End User Computing Satisfaction (EUCS) Model"
Authors: Ni Luh Manik Darmayani
Published: October 2024

This study aims to investigate the factors that influence user satisfaction with the ATLAS application for preparing Audit Working Papers, utilizing the Computing End User Satisfaction (EUCS) model. It adopts a quantitative approach with a sample of 83 auditors from KAPs in East Java Province who use the ATLAS application, selected through convenience sampling. Data analysis was performed using Partial Least Squares with SmartPLS 2.0. The findings suggest that content, accuracy, format, and timeliness positively affect user satisfaction with the ATLAS application for preparing Audit Working Papers. However, ease of use does not significantly impact auditor satisfaction as an application user.