bluuebunny/crossref_metadata_2025 huggingface dataset:
Preparation of Accounting Guidelines and Standard Operating Procedures for the Receipt and Expenditure Cycle of the Karya Mandiri Foundation
Authors: Ardhian Anwar Muhammad , Khairunnisa Hera , Muhammad Zairin Gentiga
Published: September 2024

This study aims to analyze the cash receipt and expenditure cycle currently implemented at the Karya Mandiri Foundation. In addition, this study also aims to prepare accounting guidelines and standard operating procedures for the receipt and expenditure cycle of the Karya Mandiri Foundation. This study uses the Karya Mandiri Foundation as the object of research. This foundation is a social, religious, and humanitarian institution located in the Curug area, East Jakarta. This research is a project based research using the qualitative Research and Development (R&D) method. The development model in this study uses the (ADDIE) model limited to the Analysis, Design, and Development stages. The data collection method used in this study through several methods, namely observation of the research location, interviews with foundation administrators, and documentation. The data analysis method used in this study consists of data reduction, data presentation, and drawing conclusions.
The results of this study are in the form of an accounting guideline module and Standard Operating Procedure (SOP) on the cash receipt and expenditure cycle of the Karya Mandiri Foundation. This accounting guideline will be a clear guide in recording and managing every cash receipt and expenditure transaction of the foundation. This guideline includes definitions, legal basis, account classification, and accounting treatment. Meanwhile, the Standard Operating Procedure (SOP) on the cash receipt and expenditure cycle of the foundation will be used by the foundation administrators in understanding the flow of the cash receipt and expenditure process, increasing transparency and accountability, and efficiency in the foundation's operations. This SOP includes detailed steps starting from the planning process, implementation, to reporting.
Implementation of Accounting Software in the Financial Reports of Village-Owned Enterprises Bojonggede Mandiri
Authors: Zimah Salwa Syarief , Hesti Utaminingtyas Tri , Nindito Marsellisa
Published: September 2024

There are still many Village-Owned Enterprises (VOE’s) in Indonesia that have not submitted financial reports in accordance with PDTT Village Ministerial Decree No. 136 of 2022. In fact, this is important to pay attention to because the financial reports at Village-Owned Enterprises will be used as economic decision making. This also happened to Village-Owned Enterprises Bojonggede Mandiri, the Village-Owned Enterprises has not submitted financial reports in accordance with the applicable Ministerial Decree. Therefore, the aim of this research is to implement Zahir Apps accounting software to assist in preparing financial reports for Village-Owned Enterprises Bojonggede Mandiri in accordance with PDTT Village Ministerial Decree No. 136 of 2022. The method used in this research is descriptive qualitative. Data collection techniques use two types of data sources, namely primary data and secondary data. Primary data consists of interviews, observations and documentation, while secondary data consists of Village-Owned Enterprises financial reports for the period October 2023 to March 2024. The data validity technique used is the data source triangulation technique and the data analysis technique used is data reduction, data display, and drawing conclusions. The results of this study indicate that VOE’s Bojonggede Mandiri has implemented financial reports in accordance with the applicable Ministerial Decree and Produced a profit and loss financial report, financial position reports and cash flow report using Zahir Apps. However, the VOE’s still doesn’t understand more deeply about the use of Zahir Apps. Namely by producing a profit and loss financial report, financial position report and cash flow report. Therefore, the researcher provides a draft Zahir Appa usage guidebook for VOE’s to use as a reference in preparing financial reports using Zahir Apps.
Framework Brain-Based Learning: The Impact of Critical Thinking-Based Learning on Memory and Recall
Authors: Dwiprabowo Risky , Supena Asep , Rakhman Gumgum Gumelar Fajar , Sumantri Mohamad Syarif , Islahuddin Islahuddin , Nugraheny Devita Cahyani , Faujiah Evi
Published: September 2024

The research analyzes the potential of brain-based learning based on critical thinking on memory and memory. The purpose of this study is to produce a framework of brain-based learning methods, which integrate critical thinking in the learning process to students' memory and memory abilities. This study uses a qualitative descriptive method to collect and analyze data. Through literature review, relevant studies are obtained to produce a framework that can be implemented in learning. The findings suggest that brain-based learning, which centers on critical thinking activities, positively affects both memory retention and students' recall abilities. This research emphasizes the importance of incorporating critical thinking strategies into educational practices to improve learning outcomes. In conclusion, this study highlights the significant impact of brain-based learning on memory and recall.
Content of School Mathematics Textbook: A Praxeological Analysis on Indefinite Integral
Authors: Andriatna Riki , Kurniawati Ira
Published: September 2024

Indefinite integrals are a fundamental concept in calculus. This qualitative study aims to describe the content of school mathematics textbooks on indefinite integrals. The analysis used the concept of praxeology, which includes theory, technology, and techniques, based on the Reference Epistemological Model. The primary instrument in this research was the researcher, who used data from school mathematics textbooks, including two electronic textbooks used in Indonesia, one textbook from Singapore, and one from the Cambridge curriculum. The study results included a Reference Epistemological Model for indefinite integrals, used to compare textbook content and praxeological components. Praxeological analysis shows that the theoretical and technological components of Indonesian school mathematics textbooks are more complex than those from Singapore and the Cambridge curriculum. These differences are attributed to variations in the mathematics curricula of the three regions. Therefore, the Reference Epistemological Model can guide the development of instructional materials on indefinite integrals, taking into account the complexity differences among the textbooks.

 

Materi integral adalah salah satu konsep fundamental dalam kalkulus. Penelitian ini merupakan penelitian kualitatif yang bertujuan untuk mendeskripsikan muatan pada buku teks matematika sekolah pada materi integral tak tentu. Analisis menggunakan konsep prakseologi yang meliputi teori, teknologi, dan teknik berdasarkan Referensi Model Epistemologi. Instrumen utama dalam penelitian ini adalah peneliti sendiri dengan menggunakan sumber data berupa buku teks matematika sekolah yaitu dua buku sekolah elektronik yang digunakan di Indonesia, satu buku teks matematika yang digunakan di Singapura, dan satu buku teks kurikulum Cambridge. Hasil penelitian berupa Referensi Model Epistemologi pada materi integral tak tentu yang digunakan untuk perbandingan buku dan organisasi prakseologi. Analisis prakseologi menunjukkan bahwa komponen teori, teknologi, dan teknik pada buku teks matematika sekolah dari Indonesia lebih kompleks dibandingkan dengan buku dari Singapura dan kurikulum Cambridge. Adanya perbedaan tersebut didasarkan pada muatan kurikulum yang berbeda diantara ketiganya. Dengan demikian, Referensi Model Epistemologi yang dihasilkan dapat dijadikan salah satu acuan dalam mengembangkan pembelajaran pada materi integral tak tentu, termasuk perbedaan kompleksitas antar kedua buku dapat menjadi referensi untuk digunakan sebagai sumber pembelajaran.
Developing a GeoGebra-Assisted Web-Based Learning Module for Analytical Geometry in a STEM Context
Authors: Hidayat Dayat , Palupi Evangelista L W , Susanah Susanah , Setianingsih Rini , Sancoko Candra
Published: September 2024

In modern education, incorporating technology is crucial for enhancing learning experiences and ensuring equal access to education. By integrating technology, educators can create interactive and immersive learning environments that boost student engagement and motivation. This research aims to describe the development process and results of a GeoGebra-assisted, web-based module for analytical geometry within a STEM context. The research follows the ADDIE model, which includes five stages: analysis, design, development, implementation, and evaluation. Data collection methods include questionnaires, documentation, and literature reviews. Feasibility validation assesses the module's face and content validity, focusing on content, language, and appearance. Data analysis utilizes a Likert scale to assess the validity of the module's aspect categories. The results indicate that the web-based module was developed in accordance with each stage of the ADDIE model. Expert feasibility tests show that the module demonstrates good validity in terms of content, language, and appearance.

 

Dalam pendidikan modern, mengintegrasikan teknologi sangat penting untuk meningkatkan pengalaman belajar dan memastikan akses pendidikan yang merata. Dengan mengintegrasikan teknologi, pendidik dapat menciptakan lingkungan belajar yang interaktif dan imersif yang meningkatkan keterlibatan dan motivasi siswa. Penelitian ini bertujuan untuk mendeskripsikan proses dan hasil pengembangan modul berbasis website berbantuan geogebra untuk geometri analitik pada konteks STEM. Penelitian ini merupakan penelitian pengembangan menggunakan model ADDIE yang terdiri dari 5 tahap yaitu analisis, desain, development, implementation, dan evaluation. Teknik pengumpulan data menggunakan angket, dokumentasi, literatur review. Validasi kelayakan dilakukan untuk mengetahui validitas muka dan isi pada modul berbasis website ini yang meliputi validitas konten, bahasa, dan tampilan. Analisis data menggunakan skala likert untuk mengetahui kelayakan aspek kategori. Hasil penelitian menunjukkan bahwa modul berbasis website telah dihasilkan berdasarkan tahapan setiap proses model pengembangan ADDIE dan berdasarkan uji kelayakan oleh para ahli, validitas dari modul berbasis website ini adalah baik dalam hal konten, bahasa, dan penampilan. 
Research of the motivation of future doctors to work in rural areas and small towns.
Authors:   Federal State Budgetary Educational Institution of Higher Education “Tyumen State Medical University” of the Ministry of Healthcare of the Russian Federation, Kinchagulova M. V. , Brynza N. S. ,   Federal State Budgetary Educational Institution of Higher Education “Tyumen State Medical University” of the Ministry of Healthcare of the Russian Federation, Gorbunova O. P. ,   Federal State Budgetary Educational Institution of Higher Education “Tyumen State Medical University” of the Ministry of Healthcare of the Russian Federation, Zinkevich M. E. ,   Federal State Budgetary Educational Institution of Higher Education “Tyumen State Medical University” of the Ministry of Healthcare of the Russian Federation, Zinkevich A. E. ,   Federal State Budgetary Educational Institution of Higher Education “Tyumen State Medical University” of the Ministry of Healthcare of the Russian Federation
Published: September 2024

The staffing of state medical organizations with medical personnel is one of the main factors in the implementation of the strategic goals of the state. The relevance of studying the attractiveness of public health care in rural areas and small towns for medical university students is due to the need to take preventive measures to increase the interest of future doctors in working in these areas. Purpose of the study is to develop proposals to increase the interest of future doctors in working in rural areas and small towns. Materials and methods. 529 students of Tyumen Medical University participated in the sociological study. The survey questions are aimed at identifying intentions for the future place of residence, the significance of motivating factors and measures of social support for medical workers in rural areas and small towns that can influence the employment decisions. Results. The priority for 9 out of 10 respondents is career. More than a third of respondents want to live in cities with more than a million inhabitants and about 40% – in the largest city up to 1 million people. Four out of five target students do not plan to continue working in the same locality after fulfilling their obligations to the employer. Findings. The risk of staffing in medical organizations located in some rural areas and small towns of the Tyumen region have been identified. The proposed initiatives can be taken into account by authorities and heads of medical organizations when making management decisions and help improve staffing levels in medical organizations in rural areas, small and medium-sized cities.
Medical and social aspects of the development of technologies for regulating reproductive behavior of the population.
Authors:   N. A. Semashko National Research Institute of Public Health, Mingazova E. N. ,   Biomedical University of Innovation and Continuing Education of the State Scientific Center of the Russian Federation – A. I. Burnazyan Federal Medical Biophysical Center of the Federal Medical Biological Agency of Russia,   Kazan State Medical University, Zhelezova P. V. ,   N. A. Semashko National Research Institute of Public Health, Gureev S. A. ,   Biomedical University of Innovation and Continuing Education of the State Scientific Center of the Russian Federation – A. I. Burnazyan Federal Medical Biophysical Center of the Federal Medical Biological Agency of Russia, Nepomnyashchaya G. G. ,   N. A. Semashko National Research Institute of Public Health, Mingazov R. N. ,   Research Institute for Healthcare and Medical Management of Moscow Healthcare Department
Published: September 2024

Technologies for correcting reproductive behavior of the population are based on an integrated approach, taking into account medical, economic, psychological and social aspects. Today, of particular interest are the ethnocultural features of reproductive behavior in interaction with issues of reproductive health, legal support for the health care system, taking into account migration processes, the implementation of treatment and prevention of reproductive health disorders of women and men, the formation of reproductive well-being among the younger generation, which will be successfully implemented in the future. For the successful implementation of technologies for the protection of reproductive health, regular state and institutional collection and monitoring of data on pregnancy, fertility, perinatal health trends, risk factors, including screening, early diagnosis, treatment and prevention of disorders is necessary, expanding the scope of prevention to childhood and adolescence. Today, such medical and social technologies as patronage of pregnant women in difficult life situations are defined as socially in demand; identification of risk factors for successful conception and pregnancy outcome; medical and psychological assistance to women and families based on a personalized approach; consultations on legal and social protection of women wishing to terminate an unwanted pregnancy, support during pregnancy or after an abortion; socio-psychological assistance to vulnerable groups of the population, disabled women, adolescents and young people, especially from low social strata; prevention of domestic violence and assistance to women victims of violence, including sexual violence. In order to correct the reproductive attitudes of the population, technologies are effective that reflect the significant role of society’s value priorities, including strengthening civic responsibility, understanding the national importance of the successful birth of children, and the formation of the social prestige of a large family.
Study of psychosocial factors affecting patients’ adherence to treatment of chronic diseases.
Authors:   Federal State Budgetary Educational Institution of Higher Education «Kirov State Medical University», Pokhodenko I. V. , Savinykh E. A. ,   Federal State Budgetary Educational Institution of Higher Education «Kirov State Medical University»
Published: September 2024

This research article scrutinises the psychosocial underpinnings that influence adherence to treatment among patients with chronic diseases, assuming that adherence is a multifaceted phenomenon shaped by a complex set of psychosocial factors. Purpose: the aim of the study is to uncover the complex relationship between these factors and adherence to treatment, using linear sampling to capture the dynamics and temporal evolution of adherence behaviour in the context of chronic illness. Materials and methods. Using a rigorous methodological framework, participants with many chronic conditions were included in the study, with inclusion and exclusion criteria carefully developed to ensure a representative and diverse group. The study utilised a range of validated psychometric tools to quantify psychosocial variables such as social support, stress levels and health beliefs, as well as a multifaceted approach to assess adherence combining self-report, pharmacy records and biometric measures. Advanced statistical analyses, including mixed-effects models and structural equation modelling, were used to identify relationships between psychosocial factors and adherence to treatment, taking into account the complexity and longitudinal nature of the data. Results. The findings highlight the critical role of social support in increasing treatment adherence as well as the detrimental effects of elevated stress levels, emphasising the critical interplay between individual psychological resilience and external support systems. The study also clarifies the influence of health beliefs and illness perceptions on adherence behaviour, advocating a better understanding of the cognitive and affective dimensions that determine patients’ engagement in treatment. Findings. The article concludes by arguing that a paradigm shift towards integrating psychosocial support mechanisms into holistic models of care is needed to increase adherence in chronic disease management. It calls for the implementation of health care policies and practices that not only address the biomedical aspects of chronic disease, but also the psychosocial complexities inherent in long-term disease management. Findings from the study encourage further research into specialised psychosocial interventions aimed at improving adherence and consequently quality of life for people coping with the challenges of chronic illness.
The current trends in organization of medical care during the COVID‑19 pandemic as exemplified by the Far East region of Russia.
Authors:   The Federal State Budget Scientific Institution “The N. A. Semashko National Research Institute of Public Health” of the Ministry of Science and Higher Education of the Russian Education, Karpova O. B. , Zagoruychenko А. А. ,   The Federal State Budget Scientific Institution “The N. A. Semashko National Research Institute of Public Health” of the Ministry of Science and Higher Education of the Russian Education, Nechaev V. S. ,   The Federal State Budget Scientific Institution “The N. A. Semashko National Research Institute of Public Health” of the Ministry of Science and Higher Education of the Russian Education
Published: September 2024

In Russia, during the coronavirus pandemic (2020–2021), there was a sharp increase in mortality, a deterioration in medical and demographic indicators, and as a result, the burden on the medical care system increased, both at the federal and regional levels. T h e p u r p o s e o f t h i s s t u d y is to study current trends in the organization of medical care in the context of a pandemic of a new coronavirus infection at the level of the Far East region (Republic of Buryatia). M a t e r i a l s a n d m e t h o d s . The study was conducted on the basis of official statistical observation data from Rosstat, the Russian Ministry of Health, the Ministry of Health of the Republic of Buryatia and the results of an expert survey. Methods of statistical, comparative analysis, study and generalization of experience, and sociological methods were used. Data processing was performed using SPSS22 and MS Excel 2007 software packages. R e s u l t s . In the course of the study, current trends in the organization of medical care in the context of the coronavirus infection COVID‑19 pandemic were examined using the example of the Far East region – the Republic of Buryatia, and an analytical comparison was made with all-Russian indicators. C o n c l u s i o n s . The results of the study can be used in strategic planning for the development of healthcare in other territories of the Russian Federation.
Cost of drug treatment for patients with cancer in an outpatient setting, calculated based on standards of medical care.
Authors:   N.A. Semashko National Research Institute of Public Health, Linnik S.А. , Tumenko E.E. ,   N.A. Semashko National Research Institute of Public Health
Published: September 2024

Modern oncology has achieved impressive results in terms of increasing life expectancy and reducing mortality of patients with malignant neoplasms. This has led to many patients requiring long-term outpatient treatment. The purpose of the study is to calculate the cost of treatment of patients with malignant neoplasms in the Russian Federation in an outpatient setting based on standards of medical care. Materials and methods. Based on the standards of medical care, the cost of drug treatment for patients with cancer in an outpatient setting was calculated. A comparison was made of the estimated amount with the actual costs of purchasing drugs for outpatient use. Results. Current regulations do not determine the place of use of drugs under the conditions of medical care. Criteria for classifying drugs as drugs for outpatient use are proposed. The highest drug costs for outpatient cancer patients are for the treatment of breast cancer, melanoma, kidney cancer and ovarian cancer. Conclusions. Calculating the cost of drug treatment for patients with cancer in an outpatient setting based on standards of care does not reflect the true need for treatment based on clinical guidelines.
Optimization of periodic medical examinations in an outpatient clinic using an information system with artificial intelligence.
Authors:   FBUZ Volga Regional Medical Center of the Federal Medical and Biological Agency, Romanov S. V. , Dzyubak S. A. ,   FBUZ Volga Regional Medical Center of the Federal Medical and Biological Agency,   Privolzhsky Research Medical University, Romanova T. E. ,   Privolzhsky Research Medical University, Berdutin V. A. ,   FBUZ Volga Regional Medical Center of the Federal Medical and Biological Agency, Abaeva O. P. ,   FBUZ Volga Regional Medical Center of the Federal Medical and Biological Agency,   Sechenov University
Published: September 2024

Organizing medical examinations for patients with minimal time losses is the most difficult task for an outpatient clinic when creating a New model of a medical organization providing primary health care. Since during medical examinations it is necessary to perform a whole range of works associated with certain sets of actions, the authors developed an information system with technologies of artificial intelligence, which was tested during periodic medical examinations. The purpose of the study is to develop and test an information system with technologies of artificial intelligence that allows balancing the capabilities of a medical organization and the needs of the patient when undergoing periodic medical examinations. Materials and methods. The tool for solving this problem was an artificial intelligence platform based on the principle of decision making by controlling the positions of attractors in the state space of the Hopfield neural network, which was built into the medical information system using HL7 FHIR. Results. The result of the work was the “Smart Clinic” project, which provides for the creation of an information system with technologies of artificial intelligence for routing patients during periodic medical examinations. The information system provided dynamic routing of patients in real time with the construction of the shortest trajectory and minimal movement across the floors of the building, based on current information about the workload of specialists and the duration of each stage of the examination. Conclusions. The use of an artificial intelligence information system in the outpatient clinic made it possible to reduce the average duration of a patient’s trajectory during a periodic medical examination by 45%, the average waiting time for an appointment – from 7 minutes to 3 minutes, and the total time for undergoing a preventive examination – from 200 to 150 minutes. This made it possible to increase the number of periodic medical examinations per year by 1.5 times, and the level of patient satisfaction reached 95%.
Development of an intellectual system to support medical decision-making on forecasting chronic kidney disease in children.
Authors:   Samara State Medical University, Ministry of Health of the Russian Federation, Sedashkina O. A. , Kolsanov A. V. ,   Samara State Medical University, Ministry of Health of the Russian Federation
Published: September 2024

Introduction. Chronic kidney disease is often diagnosed too late. Currently, the diagnostic accuracy is 44.1%, which highlights the urgent need to improve diagnostic methods. The purpose of the study: to develop a model – a system of support of medical decisions to predict chronic kidney disease in children. Materials and methods. А one-center retrospective cohort study (2011–2022) of children with chronic kidney disease of 1–4 stages in the age from 1 to 17 years. To construct a predictive model for diagnosing chronic kidney disease in children, an ensemble learning method was used, using which the models obtained by machine learning algorithms were combined: multi-factor logistic regression and decision tree. The models use five variables: asthenic physique in a child, loss of protein and red blood cells with urine, ESR and blood serum sodium. Results. The study involved 158 patients. The main group includes 128 children with chronic kidney disease of stage 1–4 aged 1–17. The comparison group was 30 children with no diagnosed kidney pathology aged 1 to 17. The children of the two groups did not differ statistically by sex and age. A model has been obtained to predict chronic kidney disease in children on a test sample with an accuracy of 93.5% [87.1; 100.0]%; a sensitivity of 92.0% [82.1; 100.0]; a specificity of 100.0% [100.0; 100.0.0]; ROC-AUC = 98.7%;100.0].0. Obtained model of excellent quality (>90%). The model describes 90.3% [83.8; 96.1]% variance. Conclusion. The proposed model demonstrates excellent predictive ability and may be of important clinical importance for predicting the chronic process in primary health care, where symptoms associated with the risk of chronic kidney disease, may be overlooked. Predicting and developing early nephroprotective strategies can lead to better treatment outcomes and prolong life.
Modern Civilization and Prospects for Its Development (to the 90th Anniversary of V.S. Styopin)
Authors:   Belarusian State University, Titarenko Larissa
Published: September 2024

The article attempts to combine the ideas of civilizational development formulated by V.S. Styopin with various civilizational concepts and ideas of macrosociology that became widespread in the late 20th – early 21st centuries. An interdisciplinary study of the problems of civilizational development in the era of post-non-classical science allows to show how the philosophical ideas and concepts of V.S. Styopin correlate with the ideas and concepts of representatives of social and humanitarian disciplines, including domestic and foreign sociologists. The importance of ana­lyzing the problems of civilization is largely due to the fact that they affect not only science, i.e. field of knowledge, but also the development of social reality and re­flect the changes that have occurred in Russia and the world – global antagonisms in politics, culture, everyday life. V.S. Styopin, presenting the genesis of the deve­lopment of world civilization, called our time an era of transformation of the type of civilizational development, or an era of transition from one type of civilization to another. Representatives of macrosociology, history, and political science reveal the genesis, structure, and values of the current civilization – the one that Styopin called technogenic – and analyze it in general and at local levels (including the lo­cal Russian civilization), also emphasizing the historicism and variability of any type of society. In terms of their significance, the civilizational ideas of V.S. Styopin can be considered as Russian contribution to the development of the philosophical, scientific and humanitarian revolution of our time
Howitz Dispute: Free Will, Responsibility and Madness
Authors:   Lomonosov Moscow State University, Chepeleva Natalia
Published: September 2024

For the first time, detailed information about the Howitz dispute is presented in Russian. His events are a vivid and original example of how philosophy has a decisive impact on public life. The debate about free will involve not only philosophers, but also doctors, lawyers, politicians, theologians and writers. They published works analyzing the problem of free will in the context of the philosophy of Hume and Kant, and sought to adapt the results of their re­search to Danish public life. The results of the philosophical debates related to the Howitz dispute formed the basis of the Danish legal system, but its influ­ence extends far beyond the borders of the country. The article reconstructed the events of the Howitz dispute based on the material of Danish dictionaries and studies of the 19th century, as well as a few English-language sources. It exa­mines Howitz’s philosophical concept as outlined in his major work, which pro­voked the debate. The author pays special attention to discussing the current state of historical and philosophical discussions around the dispute. The pa­per analyzes the latest hypothesis about the connection between Arthur Scho­penhauer and the Howitz controversy. It was probably in connection with the Howitz dispute that Schopenhauer’s competition essay “On the Foundation of Morals” was rejected by the Royal Danish Academy of Sciences. The article questions the assertion that the members of the competition jury knew Schopen­hauer’s philosophy well, but there is no doubt that Schopenhauer’s views were similar to Howitz’s concept, which the members of the competition jury were fiercely opposed to. Thus, the refusal Schopenhauer received from the members of the competition jury can be considered in the context of the Ho­witz dispute, which captured the Danish intellectual community in the first half of the 19th century
WITHDRAWN: The Double Glycoprotein Rabies Virus Strain Shows Increased Propagation Rate and Boosted Immunogenicity.
Authors: Alamdary Ashkan , Gholami Alireza , Azizi Mohammad , Noormohammadi Zahra
Published: September 2024

The full text of this preprint has been withdrawn by the authors while they make corrections to the work. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Revealing the Molecular Interplay of Coverage, Wettability, and Capacitive Response at the Pt(111)-Water Solution Interface under Bias
Authors: Cucinotta Clotilde S. , Raffone Federico , Khatib Rémi , Sulpizi Marialore
Published: September 2024

While electrified interfaces are crucial for electrocatalysis and corrosion, their molecular morphology remains largely unknown. Through highly realistic ab-initio molecular dynamics simulations of the Pt(111)-water solution interface in reducing conditions, we reveal a deep interconnection among electrode coverage, wettability, capacitive response, and catalytic activity. We identify computationally for the first time the experimentally hypothesised states for adsorbed hydrogen on Pt, HUPD and HUPD, revealing their role in governing interfacial water reorientation and hydrogen evolution. The transition between these two H coverage regimes with increasing potential, induces a shift from a hydrophobic to a hydrophilic interface and correlates with a change in the primary electrode screening mechanism. This results in a slope change in differential capacitance, marking the onset of the experimentally observed peak around the potential of zero charge. Our work produces crucial insights for advancing electrocatalytic energy conversion, developing deep understanding of electrified interfaces.
Centralized Traffic Signal Control for Massive-Scale Heterogeneous Trafﬁc Network via Deep Reinforcement Learning
Authors: Qiao SiYao , Wu Jia , Yi Chenglin , Ren YanYu
Published: September 2024

In order to alleviate the traffic congestion problems caused by urbanization and the increment in vehicles, researchers have proposed various methods for traffic signal optimization based on reinforcement learning. However, most of these methods focus on small-scale and homogeneous road networks. To address complex road network problems, we introduce a new method called Gen-CenLight, which utilizes a centralized control approach based on the Actor-Critic architecture. To achieve scalability and coordination in massive-scale networks, we have designed a Spatial Representation Extraction that can learn the representation of the network from a high-dimensional space. Additionally, to manage heterogeneity in the network, we have proposed an innovative Action Selection module that selects the appropriate traffic signal phases based on the specific structure of each intersection. To the best of our knowledge, our model is the first centralized control model implemented in a road network comprising thousands of intersections. Experimental results demonstrate the effectiveness of our approach in effectively managing massive-scale and heterogeneous road networks.
Matrix metalloproteinase 24 (MMP24) is a pro-fibrotic mediator in lung fibrosis
Authors: Gazdhar Amiq , Fytianos Kleanthis , Ozan Burak , Pfister Eliane , khan Petra , Boesch Maximilian , Baty Florent , Pantasis Sophia , Mykoniati Sofia , Bordoli Mattia , Rao Tata Nageswara , Brutsche Martin , Hostettler Katrin , Geiser Thomas
Published: September 2024

Idiopathic pulmonary fibrosis (IPF) represents a terminal, age-related disease characterized by a complex pathophysiology. Recent studies have reported the presence of basal cells in IPF lungs, yet their specific role and impact on other cell types within the fibrotic lung remains unclear. Lung resident mesenchymal stem cells (MSCs) are a crucial resident stem cell population essential for maintaining lung homeostasis; MSCs exhaustion, a hallmark of aging, has been implicated in IPF through poorly understood mechanisms. In this study, we investigated the effects of hepatocyte growth factor (HGF), an anti-fibrotic factor, on MSCs quiescence using a bleomycin-induced lung injury model. RNA-sequencing analysis of basal cells isolated from IPF lungs identified upregulation of matrix metalloproteinase 24 (MMP24) in IPF (2.45±0.53) compared to non-IPF basal cells (1.12±0.2) (p˂0.05). Moreover, in vivo experiments indicated increased MMP24 levels in bleomycin injured lung homogenates compared to healthy lungs (6.89±0.78 vs 3.52±0.65 ng/mL) p<0.01, and decreased frequencies of activated lung MSCs in bleomycin-injured lungs compared to healthy lungs (21.8±6.2% vs 51.0±9.3%) p<0.01. Consistently, in vivo overexpression of MMP24 resulted in enhanced quiescence of lung MSCs and increased fibrosis. Conversely, in vivo HGF gene transfer increased frequencies of activated lung MSCs (27.5±3.2%, p<0.05) and reduced MMP24 levels in lung homogenates (4.39±0.38 ng/mL, p<0.001). Mechanistically, HGF reduced MMP24 expression through the YAP-1 pathway. Collectively, our findings uncover MMP24 as a pro-fibrotic mediator in IPF patients and in bleomycin injured lung and identify HGF-YAP1-MMP24 as a novel therapeutic axis in lung fibrosis.
Cellulose Nanofibrils in Pervious Concrete: Improving Mechanical Properties and Durability
Authors: Li Jingchen , Cao Weidong , Yan Ziqi , Zhan Zunhao , Li Yingjian
Published: September 2024

Pervious concrete (PC), commonly used in urban pavement is known for its high permeability, which contributes to mitigating the urban heat island. However, the low strength and durability of PC limit its use. The objective of this study is to improve mechanical properties and durability of PC by adding cellulose nanofibrils (CNFs). The results showed that CNFs significantly enhanced compressive strength, flexural strength, and salt frost resistance, with optimal performance at 0.15% CNF. At this concentration, compressive and flexural strengths increased by 26.5% and 25.8%, respectively, despite a slight reduction in permeability. CNFs also improved resistance to salt-induced freeze-thaw cycles, reducing spalling and maintaining a higher dynamic elasticity modulus, particularly at 0.1% and 0.15% dosages. Scanning electron microscope (SEM) analyses revealed that CNFs create a denser, more uniform network of hydrated products, enhancing microstructure and interfacial bonding. This study confirms that CNFs can significantly enhance the mechanical properties and durability of PC.
Properties of a persuasive quit-smoking message based on the Elaboration Likelihood Model (ELM) from medical students’ perspective: A structured content analysis
Authors: Broujeni Razieh Beigi , Khademi Zahra , Ahmadi Zakieh
Published: September 2024

Background
Smoking is one of the biggest problems of the young generation. Several strategies have helped to reduce smoking among young people. ELM is a theoretical approach that provides guidance on developing messages that meet these needs. In this study, we decided to use the model of mental processing of beliefs as one of the effective approaches in persuasion, to investigate the process of persuasive messages to quit smoking in young people.
Method
The present study is a qualitative content analysis study that was conducted on 28 students. Structured interviews were used to collect data. Data analysis was done after each interview until data saturation was reached.
Findings:
28 students participated in this study. In this study,4 main issues of how to send the message, how to send it to the person, when to deliver the message, and the way/means of delivering the message were found. Out of the 12 extracted sub-classes,8 sub-classes were related to the peripheral path and 4 sub-classes were related to the central path of the model.
Conclusion
The views of medical students who are related to the future of society's health can be very valuable for smoking cessation.
Assessment of the Pb 2+ biosorption potential of the fungus Penicillium citrinum under geothermal conditions
Authors: Leins Alessio , Bregnard Danae , Schäpan Ilona , Zonneveld Wart , Bindschedler Saskia , Vieth-Hillebrand Andrea , Junier Pilar , Regenspurg Simona
Published: September 2024

One solution for reducing the scaling risk of lead (Pb)-containing phases is to remove the aqueous Pb2+ ions from the brine by a sorption process before oversaturation of Pb2+ phases at unwanted locations within the geothermal fluid loop. This study investigated the known capacity of fungal biomass to bind Pb2+ ions (biosorb) and thus remove Pb2+ from the brine. So far, biosorption studies have neither been done at high temperatures or salinity, nor under high pressure, three conditions that have to be considered within geothermal power plants. Thus, the overall goal of this study was to assess the Pb2+ biosorption potential of dead biomass of the fungus Penicillium citrinum strain HEK1 under conditions mimicking those of natural highly saline geothermal fluids. This specific strain was isolated from a geothermal power plant in which Pb2+ scaling occurs. The dead biomass of P. citrinum was added to synthetic solutions containing 260 g/L NaCl, 1g/L Pb, and (in half of the treatments) 60 mg/L acetic acid. These synthetic solutions, including the dead biomass, were then incubated at high pressure (8 bar) at different temperatures (25°C, 60°C, 98°C) and for different time intervals (1 h, 2 h, 3 h). Results showed that the biomass was stable in such conditions, at all temperatures tested, but small amounts of organic compounds, with a wide variety of low molecular weight (< 350 Da to 10,000 Da) have been released into the fluids from the biomass. In general, increased temperature resulted in an increase of dissolved organic carbon (DOC) concentration. Moreover, the potential for biosorption of P. citrinum HEK1 biomass was not affected by changes in temperature, time of exposure or by the presence of organic acids within the fluids. However, the biosorption potential was overall low (1.4% of total Pb2+). It nevertheless increased to about 5 to 10% of Pb2+ removal in experiments with non-saline conditions. Therefore, the high salinity of the fluids was the factor limiting the biosorption to the highest extent, highlighting that working with highly saline geothermal fluids might be limiting for biosorption processes to happen efficiently.
Adolescent depression treatment pathways in Primary Care – protocol for a longitudinal Cohort Study Describing Naturalistic Flow of Treatment and Evaluating Effectiveness and Cost- effectiveness of Interpersonal Counseling Compared to Treatment as Usual
Authors: Linnaranta Outi , Myllyniemi Aija , Salusjärvi Emma , Seilo Noora , Kaljadin Jasmin , Kukko Tiia-Reeta , Tani Sara , Kaltiala Riittakerttu , Koskinen Tarja , Karukivi Max , Karvonen Juha T. , Karri Sirene , Oksanen Juha , Heinonen Erkki , Kiviruusu Olli , Therman Sebastian , Berg Päivi , Lahti Jari , Rissanen Elisa , Lammintakanen Johanna , Ranta Klaus , Autio Reija , Marttunen Mauri
Published: September 2024

Background:Implementation of evidence-based interventions is one of the proposed responses to increased demand for treatment of adolescent depression. While the efficacy of interpersonal psychotherapy to treat depression of adolescents (IPT-A) is well established, the effectiveness and cost-effectiveness of the shorter adolescent interpersonal counseling (IPC-A) remains open.
Objective: We present a protocol for a prospective evaluation of the naturalistic treatment flow of adolescents with sustained depression, and effectiveness and cost-effectiveness of IPC-A, as compared to treatment as usual or no treatment of sustained depression.
Methods: We will collect a prospective cohort of grade 7 to 9 adolescents (13–16-year-olds) in selected Finnish schools using convenience sampling (n=9000). We will compare three groups as defined at 6 months (targeting with IPC-A, n=100; with treatment as usual (TAU), n=200; or no treatment, n=100). The primary outcome measure will be the proportion of adolescents who received specialized psychiatric services by 2 years after baseline. Secondary outcome measures will include longitudinal changes in PHQ-9-A scores by 12 months, positive mental health, social inclusion, and quality of life. Cost-effectiveness will be evaluated using survey data at 12 months, and an economic evaluation using register data and information on service use 12 months before and up to 10 years after baseline. A universal evaluation of all adolescents, independent of mood, will provide prospective description of adolescents a) with sustained depression over the follow-up period (Patient Health Questionnaire 9 items, adolescent version, PHQ-9-A ≥ 10 in two measurements over 6 months), b) with a self-reported need and motivation for support, c) with therapeutic intervention, and d) benefits and harms of treatment. We will describe the treatment received and predictors of treatment and outcome based on reports from adolescents, caretakers, and therapists, as well as electronic patient records. Impact of training in IPC-A on competence and access to treatment will be evaluated.
Conclusions: The study will describe need for, pathways to, and content of mental health services for depressed adolescents. The results can improve detection and equal access to care, and inform decision -makers about the best practices for prevention, including utility of the implementation of IPC-A.
Trial registration: ClinicalTrials.com NCT06390462 registered 2024-03-19
Investigation of the toughness behavior in cold-formed and welded high-strength steels using fracture mechanics concepts and notch impact test
Authors: Werner Tom , Nitschke-Pagel Thomas , Dilger Klaus
Published: September 2024

High-strength steels are increasingly utilized across various industrial sectors, notably in statically loaded components such as crane constructions. These steels are frequently subjected to cold forming during production, followed by welding. However, welding in cold-formed regions of structural steels often results in embrittlement, thereby elevating the risk of brittle fracture. Current standards like Eurocode 3 address this phenomenon by prescribing a minimum distance of five times the plate thickness for welding in cold-formed areas of structural steels with a minimum yield strength of 700 MPa. Failure to meet this minimum distance necessitates costly heat treatment processes. This article investigates three steels with higher yield strengths ranging from 700 MPa to 1100 MPa, featuring diverse strengths and manufacturing variations, to elucidate the influence of embrittlement during cold forming and welding of high-strength steels utilizing concepts from fracture mechanics. The results indicate that embrittlement is not anticipated in the cold-formed and welded regions of high-strength steels. It is inferred that the absence of secondary recrystallization, attributed to the existing microstructure or fine grain size of the steels, mitigates the formation of coarse grains, thereby averting brittle fracture.
Bidirectional analysis of gastroesophageal reflux disease and migraine using two-sample Mendelian randomization
Authors: Jin Xin , Zhuang Jianhua , Xu Jin
Published: September 2024

Background
Epidemiological studies suggest a link between gastroesophageal reflux disease (GERD) and migraine, but the causal relationship remains unclear. This study aimed to clarify this relationship using two-sample Mendelian Randomization (MR).
Methods
Data on GERD and migraine, including subtypes with aura (MA) and without aura (MO), were collected from genome-wide association studies (GWAS). SNPs were selected as instrumental variables (IVs) by accounting for linkage disequilibrium and removing unbalanced connections. The primary analysis used the inverse variance-weighted (IVW) method with supplementary analyses. Heterogeneity and pleiotropy were assessed using Cochran's Q test, MR-Egger intercept, and MR-PRESSO. Finally, reverse causality was explored.
Results
The IVW method indicated a causal link between GERD and increased risk of migraine (OR = 1.381, 95% CI: 1.190–1.602, p = 2.04E-05), particularly the MO subtype (OR = 1.600, 95% CI: 1.311–1.953, p = 3.67E-06). No significant association was found for MA (OR = 1.193, 95% CI: 0.983–1.449, p = 0.074). Reverse MR analysis showed no causal relationship between migraine and GERD.
Conclusion
GERD is causally linked to an increased risk of migraine, especially the MO subtype. No reverse causal relationship was found, highlighting the importance of considering migraine subtypes in understanding their association with GERD.