bluuebunny/crossref_metadata_2025 huggingface dataset:
Machine Learning Algorithms for MR Brian Image Classification
Authors:   Research scholar, Professor in Department of Electronics and Communication Engineering, Koneru Lakshmaiah Educational Foundation, Greenfields, Vaddeswaram, Guntur, AP, India., Babu* S. Sreedhar , Bojja Polaiah ,   Professor in Department of Electronics and Communication Engineering, Koneru Lakshmaiah Educational Foundation, Greenfields, Vaddeswaram, Guntur, AP, India.
Published: October 2019

Effects of Visual and Auditory Response Times in Males and Females by using Tactile and Mouse on Web Based EnvironmentClassification of MR brain images accurately is the crucial part in the medical imaging research since brain is a complex structure which needs multiple convergence approaches to classify. In this paper machine learning algorithms like SVM, HMM were employed to classify the brain images with the use of spatial features. Super pixel image segmentation approach is applied to segment the image into distinct super pixel region for which the features are calculated.
PEMBANGUNAN SISTEM INFORMASI PENGOLAHAN DATA PRODUKSI PADA UMKM KONFEKSI BERBASIS WEBSITE
Authors: Kurniawan Ady Purna
Published: October 2019

Pemanfaatan teknologi informasi sangat dibutuhkan oleh perusahaan dalam menjalankan bisnis guna dapat mengelola data-data di dalamnya agar selalu menumbuhkan profit bagi perusahaan. Rumah industri konfeksi salah satu bidang yang memiliki data-data yang harus dikelola diantaranya data pesanan, penggajian, produk, dan keuangan. Sebanyak 20 rumah industri konfeksi berbasis UMKM di Kota Bandung masih memanfaatkan proses manual dalam pengelolaan data-data selama produksi berjalan, sehingga data-data tersebut rawan terjadi kehilangan dan kerusakan. Pengembangan sistem informasi dijalankan menggunakan metode Waterfall dan dibangun menggunakan bahasa pemrograman website dengan framework CodeIgnter. Sistem informasi menggunakan dukungan perangkat barcode/QR code reader dalam mencatat hasil produksi di konfeksi. Hasil pembangunan sistem secara keseluruhan menghasilkan fitur yang mampu mengelola data-data produksi dan menghasilkan dokumen-dokumen yang dibutuhkan seperi slip gaji, kuitansi, serta laporan-laporan yang dapat digunakan oleh manager bisnis seperti laporan pesanan, penggajian, dan keuangan.
APLIKASI CATATAN PENGINGAT BERBASIS LOKASI DENGAN ANDROID
Authors: Setiawan Muhammad Riza , Djahidin Danny Yudin
Published: October 2019

Setiap manusia memiliki banyak aktivitas untuk memenuhi kebutuhannya sehari hari, namun terkadang banyak faktor yang membuat manusia lupa menjalankan aktivitasnya. Sebuah memo dapat membantu manusia akan kebutuhan aktivitasnya. Memo ini dijalankan pada android mobile. Seperti halnya membuat alarm, aplikasi ini dapat membuat banyak list aktivitas. Hasil akhir yang diharapkan adalah sebuah sistem aplikasi yang dapat menambahkan, menghapus, merubah dari sebuah memo tersebut, serta telah terintegrasi dengan maps, sehingga dapat menambahkan sebuah lokasi. Adapun manfaat dari pembuatan sistem ini yaitu mengingatkan pengguna akan aktivitasnya dan membantu terpenuhi kebutuhannya
PENGARUH PERSEPSI KEMUDAHAN DAN PERSEPSI KEMANFAATAN TERHADAP PENGGUNAAN SISTEM KKN ONLINE DENGAN PENDEKATAN TAM
Authors: Handayani Sri , Saputera Surya Ade
Published: October 2019

Kuliah Kerja Nyata (KKN) merupakan salah satu matakuliah wajib Universitas dalam kurikulum pendidikan di Universitas Muhammadiyah Bengkulu (UMB), dalam proses nya Kuliah Kerja Nyata memerlukan kinerja pengolahan data yang baik. Universitas Muhammadiyah Bengkulu telah membangun sebuah Sistem Informasi Khusus untuk menunjang Kegiatan KKN yakni sebuah website KKN secara online yang diharapkan membantu kegiatan KKN lebih cepat, efektif dan Efisien.Tujuan dari penelitian ini untuk mengetahui pengaruh persepsi kemudahan terhadap penggunaan sistem KKN Online, dan Variabel Kemanfaatan terhadap penggunaan sistem KKN Online.Menggunakan metode penelitian explanatory dengan pendekatan kuantitatif menggunakan kuesioner.Populasi dari penelitian ini yaitu mahasiswa Universitas Muhammadiyah Bengkulu yang mengikuti KKN.Hasil Penelitian ini menunjukan adanya pengaruh dari kemudahan penggunaan dan kebermanfaatan sistem terhadap penggunaan sistem, baik secara parsial maupun simultan.
Hubungan Program Germas Terhadap Kebiasaan Hidup Masyarakat Yang Telah dan Belum Mendapatkan Sosialisasi di Wilayah Kerja Puskesmas Kecamatan Sukarame Palembang
Authors: Tedi Tedi , Fadly Fadly , R Ridho
Published: October 2019

Perubahan pola penyakit yang disebut dengan transisi epidemiologi menggeser perhatian kesehatan Indonesia kepada penyakit tidak menular. Pemerintah menyusun Gerakan Masyarakat Hidup Sehat (GERMAS) sebagai wujud dari nawa cita Presiden RI. Program Germas mengedepankan upaya preventif tanpa mengesampingkan upaya kuratif dan rehabilitatif dengan tiga indikator fokus Germas. Aktivitas fisik setiap hari, mengkonsumsi sayur dan buah setiap hari dan memeriksa kesehatan secara berkala. Tujuan dari penelitian ini untuk melihat hubungan program germas terhadap kebiasaan hidup masyarakat yang telah/belum mengetahui atau mendapatkan sosialisasi program germas. Penelitian ini adalah survey analitik dengan pendekatan cross sectional, penelitian ini dilakukan di Puskesmas yang terdapat di Kecamatan Sukarame Palembang yang dilakukan pada bulan Maret sampai Juni 2018. Data diuji dengan chi square dengan analisis cross tab menggunakan aplikasi analisa statistik. Hasil uji menunjukan bahwa nilai Assymp sig pearson’s chi square sebesar 0.034 yang artinya bahwa Ho ditolak sehingga dapat diartikan ada hubungan antara program germas terhadap kebiasaan hidup masyarakat yang telah dan belum mendapatkan sosialisasi di wilayah kerja puskesmas Kecamatan Sukarame Palembang secara signifikan. Program Germas berhubungan secara signifikan terhadap kebiasaan hidup masyarakat yang telah/belum mengetahui atau mendapatkan sosialisasi program germas.
Penerapan Fuzzy Logic Pada Mobile Robot Sederhana
Authors: Fakhriza Muhammad , Senoadji Muhammad Hadi , Ananda Adelia , Pangestu Khairani Maudi
Published: October 2019

The application of fuzzy logic can be implemented in making simple robots, where the method used is the sugeno method, robo can move automatically, the robot is designed in a round shape has a tire that can move forward and backward, left and right, the robo can maintain a safe distance with the object in front of it. The results of this test indicate that the robot can work well with normal movement

Keywords : fuzzy logic
Rencana Strategis Klinik SS dalam Upaya Mewujudkan Keunggulan Bersaing (Competitive Advantage)
Authors: Syahidin Rukhiyat
Published: October 2019

Research is held at Clinic SS Bandung, using the applied theory of strategy management, a qualitative explorative approach study based on primary and secondary data which appear in descriptical method. Respondents were 50 patients of Clinic SS, which are selected using snowball sampling method. The result shows that at this time Clinic SS have many weaknesses that should be improved in order to get competitive advantage, also found several competitors around Clinic SS area that is more superior or equal to Clinic SS, also found inhibitory factors in order to achieve competitive advantage such as clinic management that have not done well, government policy which make patients tend to choose clinic which has a drugstore and BPJS service, and clinic’s management which is not efficient and effective.
Analisis Pengaruh Kualitas Layanan Elektronik (E-Service Quality) Terhadap Kepuasan Pelanggan Shopee di Bandung
Authors: Permana Hadi , Djatmiko Tjahjono
Published: October 2019

Penelitian ini bertujuan untuk mengetahui pengaruh dari setiap dimensi kualitas layanan elektronik (e-service quality) yaitu efficiency, system availiability, fulfilment, privacy, responsiveness, compensation, dan contact terhadap kepuasan pelanggan Shopee di Bandung. Sampel dalam penelitian berjumlah 400 responden yang merupakan pelanggan Shopee di Bandung. Analisis data menggunakan regresi linear berganda. Hasil dari penelitian ini menunjukkan dimensi e-service quality yaitu efficiency, system availiability, fulfilment, privacy, dan responsiveness memiliki pengaruh terhadap kepuasan pelanggan, sedangkan compensation dan contact tidak memiliki pengaruh terhadap kepuasan pelanggan. Dimensi privacy memiliki pengaruh paling tinggi terhadap kepuasan pelanggan Shopee di Bandung. Kesimpulan yang dapat diambil dari penelitian ini adalah privacy memiliki pengaruh tertinggi tetapi belum mendapatkan penilaian tertinggi dari responden.
ASFALTO MIŠINIŲ AC 11 VS IR SMA 11 S SU SKIRTINGOMIS MINERALINĖMIS MEDŽIAGOMIS EKONOMINIO EFEKTO ANALIZĖ IR VERTINIMAS / ANALYSIS AND EVALUATION OF THE ECONOMIC EFFECT OF ASPHALT MIXTURES AC 11 VS AND SMA 11 S WITH DIFFERENT GRADED AGGREGATES
Authors: Šneideraitienė Lina , Žilionienė Daiva
Published: October 2019

The European building sector is facing a pressing issue of natural resources. Importing road building materials for the asphalt surfacing increases the cost of the asphalt mixture. The asphalt surfacing mixtures shall consist of a mixture of graded aggregates accounting for 80−90% of the total volume of the asphalt mixture, or 90−96% of the total weight of the asphalt mixture and binder: road bitumen or polymer modified bitumen. In the Republic of Lithuania, asphalt mixes are designed in accordance to the Design Regulations for Road Pavement Standardized Pavement Structures KP SDK 19 and accordance to the normative documents and their requirements for graded aggregates and binders. Road builders import graded aggregates to asphalt mixes from other countries, and this increases the cost of asphalt mixes. According to the scientific researches in the Lithuanian quarry Petrašiūnai II, using unique production technology is produced class I dolomite crushed stone, which mechanical, physical properties and designed asphalt mixtures can replace imported graded aggregates. The economic question remains as to the economic effect of the most commonly used asphalt mixtures in Lithuania AC 11 VS (asphalt mixture of asphalt pavement wearing course) and SMA 11 S (crushed and mastic asphalt) made from indigenous minerals compared to imported minerals. The aim of the paper is to perform the calculation and evaluation of the economic effect of asphalt mixtures AC 11 VS, SMA 11 S with different minerals and micro-aggregate. The paper identifies and analyses the properties of asphalt test mixtures, and identifies the locations of mineral suppliers in Lithuania. According to the economic impact assessment scheme, the economic effect of asphalt mixtures AC 11 VS, SMA 11 S with different minerals and micro-aggregate was calculated. According to the calculations made, the economic effect of producing asphalt mixtures AC 11 VS, SMA 11 S with class I dolomite chips is 13−14%.
An X-Ray + Radio Search for Massive Black Holes in Blue Compact Dwarf Galaxies
Authors: Latimer Lilikoi J. , Reines Amy E. , Plotkin Richard M. , Russell Thomas D. , Condon James J.
Published: October 2019

Nearby blue compact dwarf (BCD) galaxies are arguably our best local analogs of galaxies in the earlier universe that may host relics of black hole (BH) seeds. Here we present high-resolution Chandra X-ray Observatory and Karl G. Jansky Very Large Array observations of five nearby BCDs with stellar masses of less than the Small Magellanic Cloud (M
⋆ ∼ 107–108.4
M
⊙). We search for signatures of accreting massive BHs at X-ray and radio wavelengths, which are more sensitive to lower BH accretion rates than optical searches. We detect a total of 10 hard X-ray sources and 10 compact radio sources at luminosities consistent with star-formation-related emission. We find one case of a spatially coincident X-ray and radio source within the astrometric uncertainties. If the X-ray and radio emission are indeed coming from the same source, the origin of the radiation is plausibly from an active massive BH with log (M
BH/M
⊙) ∼ 4.8 ± 1.1. However, given that the X-ray and radio emission are also coincident with a young star cluster complex, we consider the combination of an X-ray binary and a supernova remnant (or H ii region) a viable alternative explanation. Overall, we do not find compelling evidence for active massive BHs in our target BCDs, which on average have stellar masses more than an order of magnitude lower than previous samples of dwarf galaxies found to host massive BHs. Our results suggest that moderately accreting massive BHs in BCDs are not so common as to permit unambiguous detection in a small sample.
Complex Magnetospheric Accretion Flows in the Low Accretor CVSO 1335
Authors: Thanathibodee Thanawuth , Calvet Nuria , Muzerolle James , Briceño César , Hernández Ramiro Franco , Maucó Karina
Published: October 2019

Although the magnetospheric accretion model has been extensively applied to T Tauri Stars with typical mass accretion rates, the regime of very low accretion is still not fully explored. Here we report multi-epoch observations and modeling of CVSO 1335, a 5 Myr old star of solar mass that is accreting mass from the disk, as evidenced by redshifted absorption in the Hα profile, but with very uncertain estimates of mass accretion rate using traditional calibrators. We use the accretion shock model to constrain the mass accretion rate from the Balmer jump excess measured with respect to a non-accreting template, and we model the Hα profile, observed simultaneously, using magnetospheric accretion models. Using data taken on consecutive nights, we found that the accretion rate of the star is low, (4–9) × 10−10
M
⊙ yr−1, suggesting a variability on a timescale of days. The observed Hα profiles point to two geometrically isolated accretion flows, suggesting a complex infall geometry. The systems of redshifted absorptions observed are consistent with the star being a dipper, although multi-band photometric monitoring is needed to confirm this hypothesis.
The Cluster-forming Site AFGL 5157: Colliding Filamentary Clouds and Star Formation
Authors: Dewangan L. K.
Published: October 2019

We observationally investigate star formation process occurring in AFGL 5157 (area ∼13.5 pc × 13.5 pc) using a multi-wavelength approach. Embedded filaments are seen in the Herschel column density map, and one of them is identified as an elongated filamentary feature (FF) (length ∼8.3 pc; mass ∼1170 M
⊙). Five Herschel clumps (M
clump ∼45–300 M
⊙) are traced in the central part of the FF, where an extended temperature structure (T

d
∼13.5–26.5 K) is observed. In the direction of the central part of the FF, the warmer region at T

d
∼20–26.5 K spatially coincides with a mid-infrared shell surrounding a previously known evolved infrared cluster. Diffuse Hα emission is traced inside the infrared shell, suggesting the presence of massive stars in the evolved cluster. Based on the surface density analysis of young stellar objects (YSOs), embedded clusters of YSOs are traced toward the central part of the FF, and are distributed around the infrared shell. Previously detected H2O masers, H2 knots, massive protostar candidates, and an H ii region are also seen toward the embedded clusters. Using the 12CO and 13CO line data, the central part of the FF is observed at the overlapping zones of two filamentary molecular clouds (length ∼12.5 pc) around −20 and −17 km s−1, which are also connected in velocity. Our observational results suggest that the formation of massive stars appears to be triggered by a collision of two filamentary molecular clouds, which might have also influenced the birth of YSOs in AFGL 5157.
Supernova Photometric Classification Pipelines Trained on Spectroscopically Classified Supernovae from the Pan-STARRS1 Medium-deep Survey
Authors: Villar V. A. , Berger E. , Miller G. , Chornock R. , Rest A. , Jones D. O. , Drout M. R. , Foley R. J. , Kirshner R. , Lunnan R. , Magnier E. , Milisavljevic D. , Sanders N. , Scolnic D.
Published: October 2019

Photometric classification of supernovae (SNe) is imperative as recent and upcoming optical time-domain surveys, such as the Large Synoptic Survey Telescope (LSST), overwhelm the available resources for spectrosopic follow-up. Here we develop a range of light curve (LC) classification pipelines, trained on 513 spectroscopically classified SNe from the Pan-STARRS1 Medium-Deep Survey (PS1-MDS): 357 Type Ia, 93 Type II, 25 Type IIn, 21 Type Ibc, and 17 Type I superluminous SNe (SLSNe). We present a new parametric analytical model that can accommodate a broad range of SN LC morphologies, including those with a plateau, and fit this model to data in four PS1 filters (g
P1
r
P1
i
P1
z
P1). We test a number of feature extraction methods, data augmentation strategies, and machine-learning algorithms to predict the class of each SN. Our best pipelines result in ≈90% average accuracy, ≈70% average purity, and ≈80% average completeness for all SN classes, with the highest success rates for SNe Ia and SLSNe and the lowest for SNe Ibc. Despite the greater complexity of our classification scheme, the purity of our SN Ia classification, ≈95%, is on par with methods developed specifically for Type Ia versus non-Type Ia binary classification. As the first of its kind, this study serves as a guide to developing and training classification algorithms for a wide range of SN types with a purely empirical training set, particularly one that is similar in its characteristics to the expected LSST main survey strategy. Future work will implement this classification pipeline on ≈3000 PS1/MDS LCs that lack spectroscopic classification.
Sperm ultrastructure of Pochazia shantungensis (Chou & Lu) and Ricania speculum (Walker) (Hemiptera, Ricaniidae) with phylogenetic implications
Authors: Jiang Zhen , Liu Jianing , Qin Daozheng
Published: October 2019

The sperm ultrastructure of two ricaniid species,Pochazia shantungensis(Chou & Lu) andRicania speculum(Walker), was investigated using light and transmission electron microscopy. Both species have monoflagellate sperm, the shape and ultrastructure of the mature spermatozoon of these two species are similar in morphology, and 128 spermatozoa are organized into sperm bundles with their heads embedded in a homogenous matrix forming the spermatodesmata. The individual sperm is filiform and includes the head, neck and flagellum. The head is needle-like, with a bilayer acrosome and an inferior elongated nucleus which is formed of homogeneously compact and electron-dense chromatin. The neck region is indistinct and is comprised of the centriole and centriole adjunct with a homogeneous dense substance. The long flagellum has the typical 9 + 9 + 2 axoneme microtubule pattern and two symmetrical mitochondrial derivatives with an orderly array of cristae flanking both sides, and a pair of well-developed fishhook-shaped accessory bodies. Current evidence shows that ricaniid species have D-shaped mitochondrial derivatives in cross-section and a serrated electron-dense region. The phylogenetic relationship of Fulgoroidea with other superfamilies in Auchenorrhyncha is briefly discussed.
Detecting Early Developmental Delays in Children
Authors: Khan Leah
Published: October 2019

Development is a core part of the care we provide to our pediatric patients. It should be monitored and evaluated at every visit. Whether it is performing a risk assessment, longitudinal surveillance, or a formal developmental screen, this important element of pediatric medicine is a part of every interaction that we have with our patients and their families. Identifying developmental delays early and helping families to access appropriate interventions is key to providing successful outcomes for these patients. To detect delays, we must commit to using standardized screening tools and become comfortable with their interpretation. The more opportunities we have to interact with our young patients, the more opportunities we have to assess and intervene when developmental differences are noted. This ensures the best possible outcomes for our pediatric patients.

[
Pediatr Ann.
2019;48(10):e381–e384.]
Examining Patterns and Impacts of Forest Resource Extraction and Forest Degradation in Tropical Dry Forests
Authors: Choksi Pooja
Published: October 2019

Forest degradation is attributed to the excessive use of forest resources and extraction, whether for subsistence or commercial purposes. With an increase in human population pressure on forests, forest degradation is becoming a concern for the conservation of biodiversity. The high human dependence on tropical dry forests underscores the need for a complete understanding of the interaction of humans and these forests to ensure their persistence and the wellbeing of the people who depend on these resources. This chapter examines forest resource use and degradation to provide a nuanced understanding of forest degradation and the impact of forest resource use.
Issues and Challenges for Stone Mining Affected Forest Area Restoration Through Probiotic Interventions
Authors: Dubey Kumud , Dubey K. P.
Published: October 2019

The sandstone quarrying and mining in Vidhyan region of Uttar Pradesh has severely devastated the floral biodiversity of the adjacent forest area. It is necessary to conserve these areas for the protection and sustainable use of forest resources. In most of the conservation program, microbial deficiency creates problems in establishment of the vegetation and delays the natural succession. Therefore, probiotic interventions were applied to conserve these areas promptly. The probiotic beneficial microbes' interventions, due to their multifarious beneficial characters, may facilitate the upcoming of flora through enrichment of the soil, better nutrient absorption, providing resistance against different stresses, etc. Probiotic interventions may positively impact the conservation of floral diversity and restoration of stone mining-affected forest area.
Uhrf1-Mediated Tnf-α Gene Methylation Controls Proinflammatory Macrophages in Experimental Colitis Resembling Inflammatory Bowel Disease
Authors: Qi Shanshan , Li Yongkui , Dai Zheng , Xiang Mengxi , Wang Guobin , Wang Lin , Wang Zheng
Published: October 2019

Macrophages drive the pathological process of inflammatory bowel diseases (IBD) mostly by secreting proinflammatory cytokines, such as Tnf-α. Recent studies have indicated the association between epigenetic modifications and macrophage functions. However, epigenetic mechanisms regulating macrophages’ functional involvement in IBD remain unknown. In this study, we investigated whether the epigenetic regulator Uhrf1 plays a role in innate immunity by functionally regulating macrophages in intestines. We employed two transgenic strains of mice (one with Uhrf1 deficiency in macrophages [Uhrf1fl/flLyz2-Cre mice] and the other with the two mutations at Uhrf1’s DNA methylation regulatory site [Uhrf1YP187/188AA mice]) to assess their susceptibility to dextran sodium sulfate–induced colitis. We examined the cytokines derived from Uhrf1fl/flLyz2-Cre and Uhrf1YP187/188AA macrophages in response to LPS stimulation. We also analyzed the effects of proinflammatory cytokines on Uhrf1 expression in macrophages. The data demonstrated that Uhrf1 deficiency and Uhrf1YP187/188AA mutation resulted in severe colitis in the dextran sodium sulfate–treated mice. In vitro analysis revealed the hypomethylation of Tnf-α promoter and the increased Tnf-α expression in Uhrf1fl/flLyz2-Cre and Uhrf1YP187/188AA macrophages in response to LPS stimulation, and anti–Tnf-α therapy implied the key role of Tnf-α to the aggravated colitis in Uhrf1-deficient mice. Exogenous Tnf-α destabilized Uhrf1 protein through ubiquitination-mediated protein degradation, triggering macrophage activation. In conclusion, we identified that Uhrf1-mediated DNA methylation controls Tnf-α expression of macrophages in the experimental colitis resembling IBD. The epigenetic mechanisms that activate macrophages may provide new therapeutic targets for IBD treatment.
RELMα Licenses Macrophages for Damage-Associated Molecular Pattern Activation to Instigate Pulmonary Vascular Remodeling
Authors: Lin Qing , Fan Chunling , Skinner John T. , Hunter Elizabeth N. , Macdonald Andrew A. , Illei Peter B. , Yamaji-Kegan Kazuyo , Johns Roger A.
Published: October 2019

Pulmonary hypertension (PH) is a debilitating disease characterized by remodeling of the lung vasculature. In rodents, resistin-like molecule-α (RELMα, also known as HIMF or FIZZ1) can induce PH, but the signaling mechanisms are still unclear. In this study, we used human lung samples and a hypoxia-induced mouse model of PH. We found that the human homolog of RELMα, human (h) resistin, is upregulated in macrophage-like inflammatory cells from lung tissues of patients with idiopathic PH. Additionally, at PH onset in the mouse model, we observed RELMα-dependent lung accumulation of macrophages that expressed high levels of the key damage-associated molecular pattern (DAMP) molecule high-mobility group box 1 (HMGB1) and its receptor for advanced glycation end products (RAGE). In vitro, RELMα/hresistin–induced macrophage-specific HMGB1/RAGE expression and facilitated HMGB1 nucleus-to-cytoplasm translocation and extracellular secretion. Mechanistically, hresistin promoted HMGB1 posttranslational lysine acetylation by preserving the NAD+-dependent deacetylase sirtuin (Sirt) 1 in human macrophages. Notably, the hresistin-stimulated macrophages promoted apoptosis-resistant proliferation of human pulmonary artery smooth muscle cells in an HMGB1/RAGE–dependent manner. In the mouse model, RELMα also suppressed the Sirt1 signal in pulmonary macrophages in the early posthypoxic period. Notably, recruited macrophages in the lungs of these mice carried the RELMα binding partner Bruton tyrosine kinase (BTK). hResistin also mediated the migration of human macrophages by activating BTK in vitro. Collectively, these data reveal a vascular–immune cellular interaction in the early PH stage and suggest that targeting RELMα/DAMP–driven macrophages may offer a promising strategy to treat PH and other related vascular inflammatory diseases.
The Bantu Presbyterian Church in South Africa and Ecumenism, 1940–1999
Authors: Duncan Graham A.
Published: October 2019

From 1940, ecumenical developments in the Presbyterian/Congregational corpus in Southern Africa became more tortuous and complex, with an expansion of the number of denominations involved in union negotiations to include the Bantu Presbyterian Church of South Africa (BPCSA, from 1979 the Reformed Presbyterian Church in Southern Africa, RPCSA), the Congregational Union of South Africa, later the United Congregational Church of South Africa, the Presbyterian Church of Southern Africa and the Tsonga Presbyterian Church (TPC, later the Evangelical Presbyterian Church of South Africa, EPCSA). The problem statement centres around the complex situation that despite substantial similarities in doctrine, liturgy and polity, as well as involvement in the Church Unity Commission and the South African Council of Churches, the union proved to be elusive. The aim of this article is to investigate the dynamics of the developing relationships and hindrances to closer relationships in the wider South African context. This study is conducted from the perspective of the BPCSA and RPCSA, and the methodology is based predominantly on archival research.
Fact or fiction: The “four-uns” of geriatrics
Authors: Bauer Doreen
Published: October 2019

An edited version of a paper presented to the SASP whilst the author was Guest Lecturer at the University of Stellenbosch, this article presents a positive viewpoint about physiotherapy services for elderly people. There is a great deal of challenges, and potential reward, in geriatric physiotherapy, but therapists must be appropriately educated, creative and enthusiastic. A rapidly increasing elderly population, which will include physiotherapists, demands a more active contribution from physiotherapists if unnecessary dependency is to be prevented or ameliorated..
Pharmacovigilance of biosimilars – Why is it different from generics and innovator biologics?
Authors: Oza B , Radhakrishna S , Pipalava P , Jose V
Published: October 2019

Biosimilars are being marketed in India since 2000. Like biologics, biosimilars have a large size, complex structure, and complicated manufacturing process, and they are produced in a living organism. It requires specialized delivery devices for administration and needs tighter temperature control to prevent degradation. As biosimilar development follows abbreviated pathway, adverse events (AEs) previously unknown during a clinical trial may be detected postmarketing. In India, the awareness on pharmacovigilance has increased significantly after implementation of the pharmacovigilance guidance in January 2018. However, biologics require tighter monitoring to ensure their safety and efficacy. This review article discusses the importance of pharmacovigilance for biosimilars, how it is different from generics, and provides recommendations to sensitize clinicians and researchers about the requirement of a different approach to improve pharmacovigilance for biosimilars. Pharmacovigilance for biosimilars is as important as it is for innovator biologics and more important than that for generics.
Retropharyngeal ectopic parathyroid adenoma versus lymph node
Authors: Batchala PP , Rehm PK
Published: October 2019

A 66-year-old female underwent preoperative evaluation for primary hyperparathyroidism. Ultrasound (US) neck and technetium (Tc)-99m-sestamibi planar scintigraphy were negative, but single photon emission computed tomography/computed tomography (SPECT/CT) demonstrated a tracer-avid retropharyngeal nodule compatible with parathyroid adenoma (PTA). A retrospective review of CT neck angiogram (CTA) and neck magnetic resonance imaging (MRI) performed 4 months earlier for stroke evaluation revealed arterial phase hyperenhancing retropharyngeal tissue, which had been dismissed as a nonpathological lymph node. “Polar vessel sign” seen in two-thirds of PTA was also present on retrospective review of the CTA. The concordant findings between SPECT/CT and CTA were indicative of a solitary undescended ectopic PTA in the retropharyngeal space, an uncommon location. A successful surgical cure was achieved after minimally invasive parathyroidectomy. This case highlights the retropharyngeal space as an important ectopic site of PTA, limitation of US, and Tc-99m-sestamibi planar scintigraphy in identifying retropharyngeal PTA. We also discuss the role of CT and MRI and the challenge in differentiating retropharyngeal PTA from a lymph node.
Heterozygous lys169Glu mutation of glucokinase gene in a Chinese family having glucokinase-maturity-onset diabetes of the young (GCK-MODY)
Authors: Zhou W , Chen M , Zhou H , Zhang Z
Published: October 2019

We report a 24-year-old female with early-onset and persistent mild fasting hyperglycemia due to glucokinase-maturity-onset diabetes of the young (GCK-MODY). A c.505A>G (p. Lys169Glu) missense mutation of the GCK gene was identified. In silico analysis indicated that the mutation affected a conserved amino acid and is disease-causing. This report describes GCK-MODY in a Chinese family and stresses that in managing this condition it is important to avoid unnecessary drug treatment and excessive anxiety about mild hyperglycemia.
Statins and gastroesophageal reflux disease
Authors: Wijarnpreecha K , Panjawatanan P , Leelasinjaroen L , Ungprasert P
Published: October 2019

Background/Objectives:

Gastroesophageal reflux disease (GERD) is one of the common gastrointestinal disorders worldwide. Recent epidemiologic studies have suggested that use of statins may lower the risk of GERD although the results from different studies were inconsistent. This systematic review and meta-analysis were conducted with the aim to summarize all available data.

Methods:

A systematic literature review was performed using MEDLINE and EMBASE database from inception to December 2017. Cohort, case-control, and cross-sectional studies that compared the risk of GERD among statin users versus nonusers were included. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method.

Results:

A total of 4 studies (1 case control, 1 cohort, and 2 cross-sectional studies) with 14,505 participants met the eligibility criteria and were included in the meta-analysis. The risk of GERD among statin users was numerically lower than nonusers with the pooled OR of 0.89 but the result did not achieve statistical significance (95% CI, 0.60–1.33). The statistical heterogeneity in this study was moderate (I2 = 54%).

Conclusions:

The current meta-analysis found that the risk of GERD was numerically lower among statin users although the pooled result did not reach statistical significance. Therefore, more studies are still needed to further clarify this potential benefit of statins.
SUBCRITICAL HYDROTHERMAL CONVERSION (SHC) PROCESS SUPPORTED BY MICROWAVES
Authors: Ryszard Parosa
Published: October 2019

Ryszard Parosa PROMIS-TECH, Poland Subcritical Hydrothermal Conversion (SHC) process can be used for utilization of wet biomass with recovery of energetic gases and diesel-like fluids. Process is carried out in high pressure (over 200 Barr) and wet biomass is heated up to 350°C. In our research we have apply microwave system to heat wet biomass in high pressure vessel – with control of the most important process parameters like temperature, pressure, microwave power and reflection coefficient. In the first stage process was tested with use of small metallic vessel connected to microwave line (rectangular waveguide) by special ceramic window. Microwave generator 2.45 GHz with controlled output power in range of 200 W to 3 kW was applied. Sewage sludges with moisture content up to 60% were heated by microwaves to temperature from 250°C to 350°C with pressure ca 300 Barr. After heating by 15 - 20 minutes inside of vessel fluid like oil was obtained with solid particles in form of carbon black. Fluid after separation of water contains hydrocarbons – with  biodiesel structure. The similar process with conventional heating by metallic walls of vessel needs much longer time – about 40 minutes, and higher energy consumption.In the next stage a semi-industrial system was designed with process reactor in form of ceramic tube located inside of metallic cavity with two single mode microwave radiators connected to microwave generators of 2.45 GHz and with output power 3 kW (CW) each.Heating process is provided in stop/flow system: biomass inside of high pressure cavity is heated by microwaves to adjusted temperature (280 -350°C) and product is transported by heat exchanger to separator. At the same time next portion of biomass is injected to the cavity. During the process reflected microwave power was recorded. When treated material was in very high pressure, close to subcritical state, specific fluctuations of reflected power level ware observed.  Water in subcritical condition lose polar structure and dielectric constants change, but in the hydrothermal conversion process another chemical compounds are formed (for example diesel like hydrocarbons) and treated material still effectively absorb microwaves. In the described system ca 60 – 80 kg of wet biomass (with 50 – 55% of water) was treated and ca 8 – 15 kg of diesel – like fluid was obtained. Basing on the preliminary results a new industrial scale system was designed and actually is under construction. In industrial scale installation a microwave heating system of 60 kW, 915 MHz is planned, with two radiators installed along ceramic tube.  Estimated efficiency of the system is in range of 200 to 400 kg of biomass treated in hour.
Numerical Investigations of the Single-Mode Microwave Treatment Effects on Rock Breakage
Authors: Teimoori Khashayar , Hassani Ferri , Sasmito Agus Pulung , Madiseh Ali Ghoreishi
Published: October 2019

In this study, a rock model which consists of a conceptual block (host rock and ore sample) is numerically modeled by using the finite element method. The rock model is subjected to several single-mode microwave treatments with different power levels, distances from the antenna, and exposure times in order to calculate and compare the corresponding effects including temperature distribution and mechanical stress/damage profiles. The main objective of the present study is to analyze the distribution of temperature and mechanical stress at the boundary of two different attached rocks when exposed to microwaves. This enables comparing the intensity of the distribution with respect to the applied microwave input operating parameters and, consequently, understanding rock preconditioning. The results of the present study verify that an increase in temperature by microwave treatment facilitates the rock weakening process. Also, a more efficient selection of the distance from the antenna and the power level can maximize the overall impact of the microwave treatment on rock preconditioning which ultimately helps with the rock breakage mechanism.
DO A SCIENCE EXPERIMENT FOR FUTURE SCIENTISTS
Authors: Matsumura Takeko , Kanematsu Y.
Published: October 2019

It has been realized that various chemical reactions are accelerated under irradiation of MW. Such Microwave chemistry is known as time-saving, clear and eco-friendly. MW ovens are world-wide domestic tools for cooking which can serve meals quickly. Regardless of its convenience, few understand the essential mechanism of MW ovens.  For better understanding of MW chemistry, authors think it is necessary for to introduce elementary knowledge   by holding   a 1-day program of experiments by using microwave (MW) ovens.“Science with microwave oven”, 1-day program which we developed and named “Hirameki Tokimeki Science” was supported by Japan Society for the promotion of Science, has been performed over four years.More than 100 students of elementary and junior-high school have joined the program.Here we report the program, response from students.Program of experiments: “1:  Dyeing handkerchief with onion peer (*1),   2:  Cooking of pizza quickly yeast-leavened, 3:  Preparation of shining slime with fluorescein dye synthesized in nonsolvent reaction.  4.  Plasma in MW oven (*2), etc.”Students realized how MW accelerated chemical reactions and that dyeing under MW was faster and more fixed compared with the conventional methods. Besides, they could enjoy lunch with pizza and dealing with the slime, both they made. They had a good time with a bit of scientific knowledge. Through 1-day program, we can make science more familiar with students, and it will cause young students to become more interested in science, lead them to future research workers.In addition to the “Hirameki Tokimeki (Inspiration and Spark) Program, we have doneVolunteer activities at Ishinomaki, one of the most damaged cities at the Higashi Nihon Big Earthquake, in 2011.“Science with microwave oven” program surely gives students mysterious interest anddream for Science. That is “Inspire and Spark!” (*1) (*2)
SINTERING OF MLCC’S BARIUM TITANATE WITH MICROWAVES
Authors: Aguilar-Garib Juan Antonio , Tijerina-García Osvaldo , Garza-Guajardo Javier
Published: October 2019

A comparison of microwave and conventional, in an electric resistance furnace, sintered layers of dielectric base barium titanate (BaTiO3) of the kind employed for multilayer ceramic capacitors (MLCC) was performed. Two kinds of samples were used for each processing method; the layers alone without electrodes, and the green MLCC with the layers and electrodes interdigitated. Samples were exposed to microwaves for 20 minutes and heated up to 1050°C and 1150°C for sintering in a crucible with graphite that acted as reduction agent and microwave susceptor. Conventional sintering was performed in the same arrangement but lasted 120 minutes since it was found that 20 minutes was not enough time to achieve sintering. Heating rate in both cases was 10 °C/min. It was observed that the layers without the electrodes achieve about the same densification for both processes, while in the case of the green MLCC’s the results were variable, ranging from sample that became dust, to cracked samples and some well sintered ones. At least in the microwave case, it is possible that the variability of the results is due to the importance of the location of the sample in the cavity that in turn affects the electric field pattern, especially because the presence of the  electrodes that can cause overheating around them.
MEASUREMENT OF THE DIELECTRIC PROPERTIES OF LIQUID CRYSTAL MATERIAL FOR MICROWAVE APPLICATIONS
Authors: Sanchez Juan R. , Nova Vicente , Bachiller Carmen , Villacampa Belen , De la Rua Alberto , Kronberger Rainer , Penaranda Felipe , Boria Vicente E.
Published: October 2019

Liquid Crystal (LC) is an anisotropic liquid material which flows like a liquid, but at the same time its molecules have an orientational order like in the solid state [1]. Thus, LC is a promising dielectric material for designing reconfigurable devices at microwave frequencies. In order to optimize the design of reconfigurable microwave devices, accurate values of the dielectric permittivity and the loss tangent of LCs are needed. However, new LCs are not well characterized at these frequencies because of its recent use for microwave applications. Therefore, the characterization in this frequency range is required for its practical use within microwave components and devices [2].   In this work, the split-cylinder resonator method has been used for the characterization of LCs at two frequency points, i.e. 5 and 11 GHz. The method is based on the measurement of the resonance frequency and quality factor of the two states of the LC molecules for extracting the complex dielectric permittivity [3].   For achieving these two states, no electric or magnetic fields are needed, just the cell must be turned 90º inside the cavity. The dielectric properties (permittivity and loss tangent) of four different LC samples, GT3-23002 from Merck and QYPD193, QYPD142, and QYPD036 from Qingdao QY Liquid Crystal Co, have been obtained. The highest values of the dielectric anisotropy are presented for the samples QYPD036 and QYPD193, together with the highest values of the corresponding loss tangent parameters. Furthermore, it is observed for all the LCs that the loss tangent decreases and the dielectric anisotropy increases at higher frequencies, which must be taken into account in the development of reconfigurable microwave devices.
El arte como visibilizador de complejidades sociales / la complejidad social como invisibilizadora del arte
Authors: Parramon Arimany Ramon
Published: October 2019

Algunas de las prácticas artísticas contemporáneas se caracterizan por una tendencia a la desmaterialización y a la concepción de la obra-como-proceso, que dificultan su presencia y notoriedad en un contexto marcado por la hipervisibilidad y la inmediatez. Aquí se plantea que ante la necesidad de hacer inteligible la complejidad social, en un contexto de sobrexposición, el arte puede ser una forma de acción que contribuya a visibilizar la realidad como sistema complejo. Pero el arte también puede quedar socialmente excluido de esta labor, si no consigue regenerar y pluralizar sus mecanismos de producción. La producción artística, entendida desde una perspectiva sistémica, debe afrontar la gestión de la complejidad como esencia, a la vez que conectarse a otros ámbitos, disciplinas o formas de ver-entender el mundo, que comparten el objetivo de descifrar investigando para trazar futuros posibles. Desde lo productivo, el arte se inscribe en un ecosistema propio compuesto por ámbitos que conviven de forma ocasionalmente interconectada. Uno de ellos es el mercado del arte, enraizado en una economía pre-fordista, que consiste en la producción no seriada y la venta de productos “exclusivos” a clientes “exclusivos”, poseedores de excedente de capital. Otro es el modelo promovido por la acción de los poderes públicos, con el objetivo de impulsar la democratización, difusión y creación cultural. Un planteamiento de tradición malrauxista, en el que las instituciones públicas dotan a la cultura un papel vinculante y una partida económica en la tarea de contribuir a modernizar socialmente el país. Un tercer modelo de carácter híbrido y experimental, estaría caracterizado por el ensamblaje de estrategias productivas diversas, desde la autogestión, a la incursión en economías colaborativas, la creación conectada a espacios intersticiales entre el espacio artístico y el social, o la mezcla de todo ello con la financiación pública. Desde esta tercera vía se exploran elementos relacionados con su visibilidad e invisibilidad.
Reproducción y producción, aproximación a los cuidados desde unas perspectiva y focalización artísticas
Authors: Benedito Pérez Carmen
Published: October 2019

El tema fundamental de la condición de la maternidad en las sociedades y teorías contemporáneas es el de los cuidados. El asunto aquí se investiga desde una perspectiva y con una focalización artísticas.  La comunicación constará de seis apartados en el que se hace un resumen del proceso de una investigación en curso en este momento. Empezando por una introducción a nivel general y a nivel particular del tema, se detallan referentes artísticos en torno al tema de la maternidad desde los años sesenta hasta la actualidad, se expone el modo de obtención de datos en el estudio de casos y se reflexiona sobre un modo de trabajo artístico y su modo de difusión, con el que dar visibilidad a nuevas narrativas que den lugar a nuevos conceptos y discursos acerca del tema en cuestión.
Comparativa cartográfica histórica para visualizar los cambios de identidad en el paisaje. Aplicación digital: La acequia Rascaña.
Authors: Gutiérrez González María José
Published: October 2019

Con la geografía moderna tuvo lugar el florecimiento de los mapas temáticos y, en consecuencia, la maduración de la cartografía cualitativa. Esta modalidad gráfica ofreció la posibilidad de plasmar los diferentes vínculos que el hombre establecía con un lugar determinado y al mismo tiempo, construía valores de identidad en el espacio. Con el actual auge en la visualización de datos, consideramos oportuno mostrar y rescatar datos que fueron claves en otro tiempo, en especial por el ejercicio de análisis del paisaje, a través de cartografías que corren el riesgo de desaparecer. De igual modo, señalamos la fuerte tendencia en los últimos tiempos hacia la defensa y el rescate de los paisajes culturales, como alternativa ante la uniformidad del espacio impuesto. Para ello, presentamos una aplicación artística interactiva llamada Identidad Nombres, resuelta con el software Unity 3d, a través del uso de componentes y botoneras para la configuración de la interacción, junto con una visualización en un espacio tridimensional, donde se muestran y contraponen dos cartografías históricas de distintos siglos, de un mismo lugar, el paisaje moldeado mediante la organización hidráulico de la huerta valenciana, y en concreto, un intervalo de la acequia de la Rascaña, una de las ocho acequias que estructuraban el entramado de la ciudad de Valencia y sus alrededores, cuyo recorrido consideramos especialmente relevante, por su contribución histórica y cultural.