bluuebunny/crossref_metadata_2025 huggingface dataset:
Distribution & Sales Control in Music Companies in the Industrial Era 4.0: A Case Study in the Indonesian Music Industry
Authors: Sulaiman Effendi  , Edy Firmansyah
Published: April 2022

On April 4, 2018 the Government of the Republic of Indonesia through the Ministry of Industry & Trade launched the 'Making Indonesia 4.0' program as a road map towards industrial competitiveness and industrial transformation. In a step to implementing Making Indonesia 4.0, the Ministry of Industry & Trade of the Republic of Indonesia also launched the Indonesia Industry 4.0 Readiness Index (INDI 4.0). Namely the Index to measure the industry's readiness to transform and a reference to access the industry's readiness to transform itself. In Indonesia, the music industry has also developed towards 4.0, which is still intended for users of music products in Indonesia, namely Karaoke Companies. Namely a company in the tourism and entertainment industry that provides space services, musical instruments and catalogs of various songs. The problem is, the quantity of playback of each song A, B and or C still cannot be controlled properly by the Government, where and only hand over control to music publishers who have licenses and permits from the Government as an institution that controls the circulation of products and works of artists, as a result there is no clear transparency regarding reporting so that the control provided is not optimal. This results in an unequal distribution of profits, so that the profits obtained are still mostly owned by some collectors who are under the auspices of music publishers and often harm the creators of works, as well as musicians, so that they do not get the royalties or remuneration that they receive. and can also harm the Government, where the Government should derive income from taxes in the music industry. However, in reality the Government does not earn significant income from taxes in the music industry because the games from several music publishers tend to play a hidden role in generating profits in the music industry, so that the supporting infrastructure in the recording process and the process of monitoring the distribution and circulation of music products is still not yet available. exist, so that the necessary control is still weak, and provides opportunities for unequal distribution of results to creators, musicians and also the Government by Collectors due to the sale of all performance rights and mechanical rights through entertainment venues and channels.Digital Music Distribution (Music Aggregator) is not transparent and tends to harm the creators of works, musicians and also the Government regarding acceptance.
Problems of Scintigraphic Diagnosis of Inflammatory Heart Disease and Methods of Their Correction
Authors:   Tomsk National Research Medical Center, Tomsk, Russia, Ilyushenkova I.N. , Anashbaev Zh.Zh. ,   Tomsk National Research Medical Center, Tomsk, Russia, Popov E.V. ,   Tomsk National Research Medical Center, Tomsk, Russia, Sazonova S.I. ,   Tomsk National Research Medical Center, Tomsk, Russia
Published: April 2022

The present review is devoted to the issues of topical diagnostics of inflammatory myocardial diseases, problems that arise at the stages of primary data collection, processing and interpretation of results, as well as ways to solve them. The paper describes the basic principles of indication of focal pathological inclusions of radiopharmaceuticals by single-photon emission computed tomography and current approaches used in world practice to eliminate motor and respiratory artifacts that affect the diagnostic effectiveness of molecular imaging. Literature search was performed using electronic bibliographic databases, such as PubMed, E-library, Medline, GoogleShcolar.
Hyperthermia in Conservative and Palliative Treatment of Oncological Patients. Part II. Whole Body Hyperthermia
Authors:   Siberian Scientific Research Institute of Hyperthermia, Novosibirsk, Russia, Kurpeshev O.K. , Van der Zee J. ,   Erasmus Medical Centre, Cancer Institute, Rotterdam, The Netherlands
Published: April 2022

The analysis of the results of the use of whole-body hyperthermia (WBH) in patients with locally advanced, recurrent and / or metastatic tumors, which, as a rule, are radio- and chemo-resistant. Most patients were incurable, in connection with which the treatment was mainly carried out with a palliative purpose. The analysis showed that the method alone or in combination with chemo- and radiation therapy has pronounced direct and palliative effects, in some cases it provides long-term control. However, WBH can have side effects. This necessitates further improvement of the method, development of a set of preventive measures, as well as improvement of equipment for heating and thermometry.
Study of the Functional Relationship of the Brain in Patients with Asymptomic Carotidal Senosis
Authors:   V.A. Almazov National Medical Research Centre, Sanct-Petersburgh, Russia, Pospelova M.L. , Efimtsev A.Y. ,   V.A. Almazov National Medical Research Centre, Sanct-Petersburgh, Russia, Lepekhina A.S. ,   V.A. Almazov National Medical Research Centre, Sanct-Petersburgh, Russia, Trufanov G.E. ,   V.A. Almazov National Medical Research Centre, Sanct-Petersburgh, Russia, Alekseeva T.M. ,   V.A. Almazov National Medical Research Centre, Sanct-Petersburgh, Russia, Ivanova N.E. ,   V.A. Almazov National Medical Research Centre, Sanct-Petersburgh, Russia, Efimova M.Y. ,   V.A. Almazov National Medical Research Centre, Sanct-Petersburgh, Russia, Voronin A.S. ,   V.A. Almazov National Medical Research Centre, Sanct-Petersburgh, Russia, Makhanova A.M. ,   V.A. Almazov National Medical Research Centre, Sanct-Petersburgh, Russia, Mikhalicheva A.A. ,   V.A. Almazov National Medical Research Centre, Sanct-Petersburgh, Russia
Published: April 2022

Purpose: To explore functional connectivity in patients with asymptomatic internal carotid arteries stenosis of more than 60% when using hirudotherapy. Materials and methods: The analysis of the results of the examination of 15 patients aged 60 to 82 years with asymptomatic stenosis of the carotid arteries in the range of 60‒75 % was carried out. The patients underwent a course of hirudotherapy, consisting of 10 sessions. All patients underwent structural and functional magnetic resonance imaging with analysis of statistical data at rest, complaints and neurological status were assessed ‒ before and after the course of hirudotherapy. Results: When using a course of hirudotherapy in patients with asymptomatic internal carotid arteries tenosis, when analyzing the neurological status and complaints, a significant improvement in well-being was noted. During functional magnetic resonance imaging, differences in functional connectivity between the medial prefrontal cortex and other areas of the brain were determined. Activation was noted in the main structures of the network of managerial control and identification of significance. Connectivity between the leading regions of the brain increased, which is a sign of improved brain activity. Conclusion: Connectivity research can be used to study the functioning of brain networks and to determine the effectiveness of therapy. The course of hirudotherapy significantly changed the functional connectivity of the brain regions, the changes correlated with a decrease in the number of complaints. This work is a pilot and will be continued for the further development of treatment-and-prophylactic strategies with the inclusion of hirudotherapy in patients with a high risk of vascular accidents in a treatment.
Perbaikan Rute Distribusi Kerupuk Kulit yang Efisien dengan Metode Saving Matrix
Authors: Cahyadi Ujang , Manaf Jayan Abdul
Published: April 2022

Tujuan pada penelitian ini yaitu untuk menentukan suatu rute pendistribusian produk yang baik dan optimal, selain itu untuk mengetahui besarnya penghematan biaya proses distribusi. Pengolahan pada penelitian ini menggunakan metode saving matrik. Data yang diolah merupakan data yang berkenaan dengan perusahaan di megarasa dorokdok yang terdapat dalam data primer dan data sekunder. Data primer didapatkan berdasarkan observasi langsung di Megarasa Dorokdok dan melakukan hasil wawancara dengan pemilik perusahaan untuk mendapatkan data pasar rute pendistribusian kerupuk kulit, data biaya pengiriman, dan data permintaan tiap konsumen. sedangkan data sekunder dari peneltian ini yaitu data jarak tiap lokasi yang didapatkan berdasarkan hasil pengukuran dari Google Maps. Dorokdok Megarasa melakukan pendistribusian 6 kali dalam semninggu yang didistribusikan ke 12 pasar yang ada di kabupaten Garut dengan jarak 431,4 Km, dan dari rute pendistribusian saat ini perusahaan harus mengeluarkan biaya distribusi sebesar Rp. 1. 527.519/ minggu. Hasil pada metode saving matrix ini menunjukan jumlah rute pendistribusian dapat di minimalkan dari semula 6 kali pendistribusian dalam seminggu menjadi 3 kali pendistribusian dalam seminggu. Dengan hal ini jarak tempuh yang semula 431,4 km dapat dipersingkat menjadi 375,3 km. Dengan adanya penurunan rute menghasilkan biaya pendistribusian minimal dari semula Rp. 1. 527.519/ minggu menjadi Rp. 886.904. Dengan hal tersebut dapat menghemat biaya pendistribusian sebesar Rp.640.615. Hasil pada metode saving matrix ini menunjukan jumlah rute pendistribusian dapat di minimalkan dari semula 6 kali pendistribusian dalam seminggu menjadi 3 kali pendistribusian dalam seminggu. Dengan hal ini jarak tempuh yang semula 431,4 km dapat dipersingkat menjadi 375,3 km. Dengan adanya penurunan rute menghasilkan biaya pendistribusian minimal dari semula Rp. 1. 527.519/ minggu menjadi Rp. 886.904. Dengan hal tersebut dapat menghemat biaya pendistribusian sebesar Rp.640.615
Analisis Kualitas Produk Jaket Touring untuk Meminimasi Defect
Authors: Chandrahadinata Dody , Taptajani Dedi Sa’dudin , Ramdani Muhamad Sidqi Musabik
Published: April 2022

Konveksi Juan Racing adalah perusahaan yang bergerak dibidang produksi jaket. Penelitian ini berfokus pada bagian produksi, Juan Racing masih menghadapi beberapa masalah, salah satunya adalah masih adanya produk cacat yang diproduksi sehingga menyebabkan menurunnya kualitas produk itu sendiri.Tujuan dilakukan Penelitian ini untuk mengidentifikasi faktor-faktor yang menyebabkan terjadinya cacat produk jaket pada konveksi Juan Racing. Untuk menentukan usulan perbaikan kualitas dengan menggunakan SQC (Statistical Quality Control) dan FMEA (Fault Mode and Effect Analysis). Pada proses produksinya Konveksi Jaket Juan Racing selalu berusaha memberikan yang terbaik terhadap konsumen, baik dari segi harga maupun kualitas. Konveksi ini juga dihadapkan dengan permintaan pasar yang semakin meningkat dan menuntut mutu terbaik. Sehingga diperlukan peningkatan kualitas yang bertujuan untuk meningkatakan kualitas dari produk yang dihasilkan oleh Konveksi Jaket Pada Juan Racing.
KAHOOT! Sebagai Alat Evaluasi Pembelajaran Dikombinasikan dengan Aplikasi Math: Aritgeo Saat Pandemi COVID-19
Authors: Setiani Rizky Nurul , Firmansyah Dani
Published: April 2022

Di era pendidikan digital abad 21 ini, perkembangan teknologi sekaligus ilmu pengetahuan menuntut adanya sumber daya  manusia yang handal serta kompeten di bidangnya. Perkembangan teknologi yang ada tidaklah terlepas dari perkembangan yang ada dalam dunia pendidikan khususnya matematika. Untuk mengikuti tren pembelajaran digital dibutuhkan inovasi pembelajaran yang baru maupun dengan pengembangan yang disesuaikan dengan latar belakang peserta didik maupun kepribadiannya demi menunjang kreativitas belajar matematika peserta didik. Disini akan digunakan media penunjang pembelajaran untuk materi barisan dan deret aritmatika yaitu aplikasi berbasis android Math:AritGeo untuk selanjutnya akan dievaluasi guru dengan menggunakan platform kahoot! yaitu pemberian tes berupa soal pilihan ganda, puzzle dan soal open-ended. Pengambilan sampel dikategorikan menjadi kelompok yang menyukai matematika, biasa saja dengan matematika, dan tidak menyukai matematika. Pengambilan kategori berdasarkan angket yang disebarkan dan diisi oleh siswa kelas XI SMA tahun ajaran 2019/2020 yang menjalani kegiatan study from home. Tujuan dari penelitian ini adalah untuk mengidentifikasi aplikasi Math:AritGeo serta kahoot! dapat dijadikan pilihan yang memudahkan dan tidak membuat siswa bosan selama kegiatan pembelajaran di rumah dalam usaha pemerintah memutus rantai covid-19. Teknik pengambilan data menggunakan instrumen butir soal dan instrumen  angket. Analisis data menggunakan teknik mix method secara deskriptif. Berdasarkan hasil penelitian dapat disimpulkan bahwa aplikasi Math:AritGeo mendapat respon sangat baik dengan presentase 95% serta kahoot! juga mendapatkan respon positif dengan rata-rata hasil nilai evaluasi siswa 90.
Pengaruh Model Pembelajaran Teams Games Tournament (TGT) Terhadap Kemampuan Pemecahan Masalah Matematis Siswa
Authors: Sari Maila , Oktafia Mesi , Ningsih Febria
Published: April 2022

Mampu memecahkan masalah adalah suatu kemampuan matematika yang penting dimiliki oleh siswa. Namun kenyataannya, kemampuan memecahkan masalah matematika dikalangan siswa masih tergolong rendah. Rendahnya kemampuan pemecahan masalah matematis dibuktikan dengan adanya penelitian-penelitian sebelumnya yang mengungkapkan bahwa kemampuan memecahkan masalah yang rendah dikarenakan pemilihan model pembelajaran yang kurang efektif dan relevan. Kurangnya keterlibatan siswa secara aktif dalam mengkontruksikan penegtahuan yang dimiliknya dalam proses belajar mengajar, menyebabkan rendahnya kemmapuan siswa dalam memecahkan masalah. Tujuan penelitian ini untuk menganalisis pengaruh model pembelajaran Teams Games Tornament (TGT) terhadap kemampuan pemecahan masalah matematis siswa kelas VIII SMP 24 Kerinci pada materi Relasi dan Fungsi. Penelitian ini merupakan penelitian eksperimen semu dengan pretes-postest. Instrument yang digunakan dalam penelitian ini adalah tes yang berupa 5 butir soal essay. Populasi penelitian ini adalah semua siswa kelas VIII SMP Negeri 24 Kerinci yang terdiri atas 2 kelas. Teknik analisis data dilakukan dengan menggunakan uji-t. Dari hasil perhitungan diperoleh rata-rata untuk kelas eksperiment 76,2 dan rata-rata untuk kelas kontrol adalah 65,08. kemudian dengan menggunakan uji t diperoleh thitung = 5,28 , sedangkan nilai ttabel = 1,668, karena thitung > ttable maka Ho ditolak dan H1 diterima. Hal ini berarti terdapat perbedaan kemampuan memecahkan masalah antara siswa yang menggunakan model pembelajaran TGT dengan yang menggunakan metode ceramah.

Kata Kunci: Kemampuan Pemecahan Masalah, Teams Games Tournament, Metode ceramah
PENGEMBANGAN E-MODUL INTERAKTIF BERBASIS PROBLEM BASED LEARNING (PBL) PADA MATA KULIAH KALKULUS
Authors: Ndi Sarwandi Wan , Siagian Meryance Viorentina
Published: April 2022

Saat ini Corona menjadi pembicaraan yang hangat, di belahan bumi manapun, corona masih mendominasi ruang publik. Beberapa pemerintah daerah menerapkan kebijakan untuk meliburkan mahasiswa dan mulai menerapkan metode belajar menggunakan sistem daring atau online. Sistem pembelajaran daring merupakan sistem pembelajaran tanpa tatap muka secara langsung antara dosen dengan mahasiswa, tetapi semua dilakukan secara online menggunakan jaringan internet. Dosen harus memastikan kegiatan belajar mengajar tetap berjalan meskipun mahasiswa berada di rumah. Dosen dituntut dapat mendesain media pembelajaran sebagai inovasi dengan memanfaatkan media daring, salah satu pemanfaatan media daring yaitu pembuatan media pembelajaran atau bahan ajar elektronik. Permasalahan yang dihadapi mahasiswa dalam pembelajaran kalkulus adalah belum tersedianya bahan ajar yang dapat diakses secara online serta belum mempunyai kemampuan analisis untuk menghubungkan antara kalkulus yang diperoleh dengan permasalahan yang ada lingkungan sekitar. Tujuan dari penelitian ini adalah mengembangkan e-modul interaktif berbasis problem based learning. Metode penelitian yang digunakan di dalam penelitian ini adalah research and development dengan model pengembangan Four-D (4-D) yang terdiri dari 4 tahap, yaitu: define, design, develop, dan disseminate. Di dalam penelitian ini hanya menggunakan 2 tahap saja karena keterbatasan waktu dan biaya. Hasil dari penelitian dan pengembangan ini adalah menghasilkan e-modul interaktif berbasis problem based learning yang bisa membantu mahasiswa dalam proses pembelajaran
PROFIL BERPIKIR INTUTIF SISWA DALAM PEMECAHAN MASALAH MATEMATIKA DITINJAU DARI KEMAMPUAN BERPIKIR LOGIS SISWA
Authors: Indah Nanda Sintia Rosa , Fadiana Mu'jizatin
Published: April 2022

Berpikir intuitif merupakan suatu proses kognitif yang memunculkan ide secara spontan yang bersifat segera (immediate) atau tiba-tiba (sudently). Sebagai strategi untuk menemukan cara terbaik untuk menemukan solusi yang akan digunakan dalam menyelesaikan permasalahan matematika. Siswa dalam menyelesaikan masalah matematika diperlukan kemampuan berpikir intuitif sebagai “jembatan berpikir” ketika siswa mengalami kesulitan dalam menyelesaikannya. Bukan hanya kemampuan berpikir intuitif yang harus dimiliki siswa melainkan kemampuan berpikir logis juga diperlukan oleh setiap siswa, saat melakukan pemecahan masalah. Dimana dalam berpikir intuitif juga dibutuhkan kemampuan berpikir logis untuk mengasilkan pemecahan masalah yang baik dan benar. Penelitian ini bertujuan untuk mendeskripsikan karakteristik berpikir intuitif siswa dalam pemecahan masalah matematika ditinjau dari kemampuan berpikir logis siswa. Penelitian ini merupakan penelitian deskriptif dengan pendekatan kualitatif. Instrumen penelitiannya berupa tes kemampuan berpikir logis, tes berpikir intuitif dan wawancara. Penelitian ini melibatkan 25 siswa yang terdiri dari 3 siswa laki-laki dan 22 siswa perempuan. Pemgambilan subjek menggunakan Tes Kemampuan Berpikir Logis (TKBL) yang diadaptasi dari GALT (The Group Assesment of Logical Thinking). Hasil penelitian menunjukkan bahwa subjek tahap operasional konkret menyelesaikan tes berpikir intuitif melibatkan beberapa sifat intuisinya diantaranya: Extrapolativiness, Implicitness dan Self-evident serta melibatkan karakteristik berpikir intuitif Power Of Synthesis , sedangkan subjek tahap transisional dalam menyelesaikan tes berpikir intuitif melibatkan beberapa intuisinya diantaranya: Extrapolativiness dan Self-evident serta menggunakan karakter berpikir intuitif Catalyc Inference. Sedangkan subjek tahap operasional formal dalam menyelesaikan tes berpikir intuitif melibatkan beberapa intuisinya diantaranya: extrapolativiness dan self-evident serta melibatkan karakter berpikir intuitif common sense
ANALISIS KESALAHAN SISWA MENYELESAIKAN SOAL MATERI SISTEM PERSAMAAN LINEAR DENGAN METODE ELIMINASI GAUSS-JORDAN
Authors: Afri Lisa Dwi , Lestari Novia
Published: April 2022

Penelitian ini bertujuan untuk mengetahui kesalahan siswa dalam menyelesaikan soal Sistem Persamaan Linear (SPL) dengan metode Gauss-Jordan dan faktor penyebab kesalahan tersebut. Penelitian ini merupakan penelitian deskriptif kualitatif. Subjek penelitian adalah siswa kelas XII-IPA2 MAN BatuBara . Analisis data dilakukan dengan cara pengumpulan data, penyajian data, reduksi data, dan menarik kesimpulan. Hasil penelitian menunjukkan bahwa kesalahan yang dilakukan siswa dalam menyelesaikan Sistem Persamaan Linear metode Gauss-Jordan yaitu (a) kesalahan fakta, (b) membuat model matematika, (c) kesalahan operasi, (d) kesalahan penulisan angka dan (e) kesalahan tidak menjawab soal. Kemudian faktor yang menyebabkan kesalahan siswa yaitu (a) faktor kesalahan fakta (b) faktor kesalahan konsep, (c) faktor kesalahan operasi, (d) faktor kesalahan kecerobohan, dan (e) faktor kesalahan penarikan kesimpulan.
Phosphodiesterase-5 Inhibitor Attenuates Anxious Phenotypes and Movement Disorder Induced by Mild Ischemic Stroke in Rats
Authors: Yu Yeon Hee , Kim Seong-Wook , Kang Juhyeon , Song Yejin , Im Hyuna , Kim Seo Jeong , Yoo Dae Young , Lee Man-Ryul , Park Dae-Kyoon , Oh Jae Sang , Kim Duk-Soo
Published: April 2022

Objective : Patients with mild ischemic stroke experience various sequela and residual symptoms, such as anxious behavior and deficits in movement. Few approaches have been proved to be effective and safe therapeutic approaches for patients with mild ischemic stroke by acute stroke. Sildenafil (SIL), a phosphodiesterase-5 inhibitor (PDE5i), is a known remedy for neurodegenerative disorders and vascular dementia through its angiogenesis and neurogenesis effects. In this study, we investigated the efficacy of PDE5i in the emotional and behavioral abnormalities in rats with mild ischemic stroke.Methods : We divided the rats into four groups as follows (n=20, respectively) : group 1, naïve; group 2, middle cerebral artery occlusion (MCAo30); group 3, MCAo30+SIL-pre; and group 4, MCAo30+SIL-post. In the case of drug administration groups, single dose of PDE5i (sildenafil citrate, 20 mg/kg) was given at 30-minute before and after reperfusion of MCAo in rats. After surgery, we investigated and confirmed the therapeutic effect of sildenafil on histology, immunofluorescence, behavioral assays and neural oscillations.Results : Sildenafil alleviated a neuronal loss and reduced the infarction volume. And results of behavior task and immunofluorescence shown possibility that anti-inflammation process and improve motor deficits sildenafil treatment after mild ischemic stroke. Furthermore, sildenafil treatment attenuated the alteration of theta-frequency rhythm in the CA1 region of the hippocampus, a known neural oscillatory marker for anxiety disorder in rodents, induced by mild ischemic stroke.Conclusion : PDE5i as effective therapeutic agents for anxiety and movement disorders and provide robust preclinical evidence to support the development and use of PDE5i for the treatment of mild ischemic stroke residual disorders.
Surgical Treatment for Trigeminal Neuralgia
Authors: Park Chang Kyu , Park Bong Jin
Published: April 2022

Various treatments for trigeminal neuralgia (TN) are known to yield initial satisfactory results; however, the surgical treatment has excellent long-term outcomes and a low recurrence rate. Surgical treatment addresses the challenge of vascular compression, which accounts for 85% of the causes of TN. As for surgical treatment for TN, microvascular decompression (MVD) has become the surgical treatment of choice after Peter J. Jannetta reported the results of MVD surgery in 1996. Since then, many studies have reported a success rate of over 90% for the initial surgical treatment. Most MVDs aim to separate (decompress) the culprit vessel from the trigeminal nerve. To increase the success rate of surgery, accurate indications for MVD and management of the offender vessels without complications are critical. In addition, if there is no vascular compression, partial sensory rhizotomy or internal neurolysis can be performed to improve surgical outcomes.
Overlapping Stents-Assisted Coiling for Vertebral Artery Dissecting Aneurysm : LVIS Stent within Neuroform EZ Stent
Authors: Liu Xing-Long , Wang Bin , Zhao Lin-Bo , Jia Zhen-Yu , Shi Hai-Bin , Liu Sheng
Published: April 2022

Objective : To evaluate the safety and efficacy of an overlapped stenting-assisted coiling technique in treating vertebral artery dissecting aneurysm (VADA) via Low-profile Visualized Intraluminal Support (LVIS) stent-within-Neuroform EZ stent.Methods : From January 2017 to June 2019, 18 consecutive patients with VADAs (ruptured : unruptured=5 : 13) were treated with the overlapping stents assisted-coiling technique in our center. The overlapping manner was a Neuroform EZ stent being deployed first, followed by LVIS stents placement using the ‘shelf’ technique. The patients’ clinical characteristics, technical feasibility and safety, and immediate and follow-up angiographic results were retrospectively reviewed.Results : Seventeen (94.4%) procedures were technically successful with an exact deployment of the stents and patent parent or perforator arteries. The immediate angiographies after procedure confirmed Raymond class I, II, and III occlusion of VADAs were in 12 (66.7%), two (11.1%), and four cases (22.2%), respectively. Post-procedural complications developed in one patient (5.6%) with minor brainstem infarctions, which resulted from an in-stent thrombosis during the procedure. Angiographic follow-up at 5.7 months (range 3 to 9 months) demonstrated Raymond class I and II occlusion were in all cases (100%). The modified Rankin Scale scores at 21.3 months (range 15 to 42 months) 0–2 in 17 cases (94.4%) and three in one case (5.6%).Conclusion : Overlapping stents via LVIS stent-within-Neuroform EZ stent combined with coiling is safe and effective for patients with VADA in the midterm results.
Antiemetic Prophylaxis with Ramosetron for Postoperative Nausea and Vomiting in Patients Undergoing Microvascular Decompression : A Prospective, Randomized Controlled Trial
Authors: Koo Chang-Hoon , Ji So Young , Bae Yu Kyung , Jeon Young-Tae , Ryu Jung-Hee , Han Jung Ho
Published: April 2022

Objective : This prospective, randomized, double-blinded trial aimed to evaluate the efficacy and safety of prophylactic ramosetron administration against postoperative nausea and vomiting (PONV) in patients undergoing microvascular decompression (MVD).Methods : In this study, 100 patients undergoing MVD were randomly allocated to the control (normal saline, 2 mL) or ramosetron (ramosetron, 0.3 mg) groups at the end of surgery. The incidence and severity of PONV, need for rescue antiemetics, patient satisfaction score, duration of hospital stay, and the occurrence of adverse events were evaluated 48 hours post-surgery.Results : Data obtained from 97 patients were included in the final analysis. The incidence of PONV was significantly lower in the ramosetron group than in the control group throughout the 48-hour postoperative period (29.2% vs. 51.0%, p=0.028). A similar trend was observed with regard to PONV severity (p=0.041). The need for rescue antiemetics, satisfaction score, duration of hospital stays, and the occurrence of adverse events did not significantly differ between the groups.Conclusion : Prophylactic ramosetron administration reduced the incidence and severity of PONV in patients undergoing MVD without causing serious adverse events. Thus, ramosetron use may improve patient recovery following MVD.
Tuberculose e multirresistência a drogas: uma revisão integrativa
Authors: Alves Laís Ferreira , Holanda Elison Costa , Sousa Leticia Thamanda Vieira de , Santos Giovanna Fernandes Lago , Andrade Sâmia Moreira de , Oliveira Evaldo Hipólito de
Published: April 2022

A resistência desenvolvida por Mycobacterium tuberculosis aos medicamentos utilizados no tratamento constitui um grande problema de saúde pública em vários Países e é considerada um dos principais obstáculos para o controle da tuberculose em todo o mundo. Desse modo, objetivou-se analisar os fatores associados à prevalência de tuberculose resistente a múltiplas drogas, através de uma revisão integrativa da literatura dos últimos 5 anos, utilizando as bases de dados LILACS, MEDLINE e SCIELO, que compõe a Biblioteca Virtual em Saúde. Houve como resultado 726 artigos, dos quais 49 foram pré-selecionados para serem lidos na íntegra, resultando em 14 artigos aprovados. Observou-se que muitos dos artigos aceitos tinham como local de estudo o continente Asiático e a américa do sul. Portanto, as estratégias no controle da TB-MDR devem enfatizar a implementação eficaz da estratégia a vigilância contínua da resistência aos medicamentos e abordagens centradas no paciente.
Possible therapeutic options and management of COVID-19
Authors: Ayobami Matthew Olajuyin , Adefunke Kafayat Olajuyin , Ayodeji Mathias Adegoke , Saliu Jamiyu Ayodeji , Hayatu Raji Muhammed , Malachy Okeke Ifeanyi , Xiaoju Zhang
Published: April 2022

Currently, there is no effective therapy against Coronavirus disease 2019 (COVID-19). Thus, there is crucial requirement for effective therapy against COVID-19. To our knowledge, few investigations have been conducted on AT2 progenitor cells as target for the (SARS-CoV-2). Hence, alveolar type 2 progenitor cells may be a possible therapeutic agent against COVID19. This review focused on the pathogenesis and pathophysiology of COVID19 disease on AT2 cells and explored potential mechanisms to prevent infection and death of AT2 progenitor cells as possible therapy against COVID-19. We propose that inhibition of IL-1 receptor, IL 1, NFkB and JNK signalling pathway may serve as therapeutic target for COVID-19
Brinquedoteca e atividades lúdicas: Uma ferramenta de cuidado na hospitalização da criança
Authors: Alves Ana Lúcia Naves , Santos Larissa Christiny Amorim dos , Toledo Cintia , Coutinho Andre Abba , Baesso Mayra Miranda , Neves Keila do Carmo , Fassarella Bruna Porath Azevedo , Ribeiro Wanderson Alves , Amaral Fernando Salgado do
Published: April 2022

Este trabalho se trata de uma pesquisa bibliográfica narrativa que teve por objeto os benefícios percebidos pela equipe de enfermagem na criança hospitalizada com o uso da brinquedoteca. Objetivou verificar a percepção do profissional de enfermagem da criança na pediatria em hospitais que utilizam a brinquedoteca. Elencar as atividades lúdicas desenvolvidas na pediatria com as crianças hospitalizadas. Levantar os benefícios percebidos na criança a partir do uso da brinquedoteca ou do desenvolvimento de atividades lúdicas com aquelas que não podem sair do leito. O material coletado foi analisado e os dados agrupados de acordo com os pontos de convergência. Evidenciou-se a falta de artigos científicos acerca do tema buscado. Durante o estudo percebeu-se a importância de utilizar a brinquedoteca como estratégia terapêutica que facilite a recuperação das crianças internadas e as dificuldades encontradas pelos dos profissionais de enfermagem no uso da brinquedoteca com terapia adjunta ao tratamento da doença.
Atividade antitumoral e inibitória de topoisomerase II-α humana do flavonoide luteolina isolado de Prosopis juliflora
Authors: Diniz Rosiane Aleixo , Silva Adrielle Antônia da , Cavalcante Giani Maria , Lins Luiz Andrade
Published: April 2022

Este estudo objetivou avaliar a atividade antitumoral e inibitória da topoisomerase II-α humana do flavonoide luteolina isolado de Prosopis juliflora frente a células tumorais prostáticas (PC-3), com o intuito de investigação de novos fármacos de origem natural. Testes in vitro foram conduzidos com os extratos brutos das folhas frente as linhagens de células PC-3 e linhagem FGH. Os testes de citotoxicidade foram realizados através de MTT (3- (4,5-dimetiazol-2il) 2,5-difenil tetrazólio de brometo) com monitorização após 24 h de exposição das células tumorais e não tumorais a diferentes concentrações dos extratos (100; 50; 25; 10 μg/mL). A luteolina extraída das folhas da P. juliflora apresentou resultados positivos sobre a inibição de DNA topo II-α  enzima essencial no processo de replicação das células cancerígenas a partir da concetração 50 µM. Ademais, apresentou atividade antitumoral frente a células PC-3 a partir da menor concentração testada 10 µM, e ausência de citotoxicidade frente a células normais. Sugere-se o estudo químico para extração e isolamento de compostos ativos oriundo dos extratos de folha da P. juliflora, para investigar a possível atividade antitumoral destes compostos em ensaio in vitro e in vivo.
Selective flocculation and floc-flotation of iron bearing mineral slimes
Authors: Bretas Pedro Lopes , Rodrigues Otávia Martins Silva , Luz José Aurélio Medeiros da
Published: April 2022

The mineral processing of friable iron ores usually generates ultrafine (smaller than 15 µm) particles, normally called slimes, which usually have a high iron grade and are usually disposed into tailings dam. The traditional mineral process techniques for iron ore do not work efficiently with ultrafines; however, selective flocculation is an alternative to concentrate that fraction. The physical-chemical treatment of iron ore slime was studied here, on a bench scale, based on the scientific foundations of selective flocculation and flotation. Samples of slimes from two Brazilian iron ore processing plants (CEII and VGII) and industrial process waters were used in the tests. Complexometric titration of calcium and magnesium indicated that the process waters were adequate for selective flocculation. Only selective flocculation, even under optimum conditions, did not achieve good results. However, its use prior to flotation led to promising results. The VGII sample has stood out, for which the final concentrate achieved 60.1 % of Fe, the mass recovery was 64.5 % and 13.5 % of Fe in the tailing, resulting selectivity index of 6.58, only with one stage of selective flocculation and one stage of flotation.
Patrimônio etnobotânico: Plantas medicinais em Mogi das Cruzes-SP
Authors: Oliveira Beatriz Goulart , Barbosa Fernando dos Reis , Bonini Luci Mendes de Mello , Scabbia Renata Jimenez de Almeida
Published: April 2022

Estudam-se as plantas medicinais em Mogi das Cruzes e seus usos em remédios caseiros. O objetivo deste trabalho é levantar conhecimento sobre as plantas medicinais utilizadas pela população do município de Mogi das Cruzes, SP. Trata-se de estudo descritivo de abordagem qualitativa de corte transversal. Participaram 100 cidadãos moradores de Mogi das Cruzes, nos meses de agosto a setembro de 2019. A coleta de dados foi realizada por meio de um questionário a fim de identificar os tipos de plantas medicinais conhecidas e usadas pela população e a finalidade de cada uso. Os resultados demonstraram que 66,5% dos participantes utilizam plantas para fins medicinais, e a maior parte (71,21%) utiliza a partir de hortas ou quintais de suas residências. Foram mencionadas 73 espécies, distribuídas em 35 famílias. As plantas para fins medicinais mais citadas foram a melissa (Melissa officinalis L., citada 19 vezes), o boldo (Plectranthus barbatus Andr., 13), a couve (Brassica oleracea L., 10), o alecrim (Rosmarinus officinalis L., 7), a camomila (Chamomilla recutita L., 7), o guaco (Mikania glomerata Spreng, 7), o poejo (Mentha pulegium L., 7), a laranja (Citrus sp., 6), a salsinha (Petroselium crispum (Mill) Nym, 5) e a rosa branca (Rosa alba L., 4). A maioria as utiliza como chás, em seguida vêm banho, suco e xarope. O uso de plantas medicinais requer tempo e conhecimento; essa prática pode contribuir para conservação de biodiversidade e sua divulgação a cada geração promove a preservação da cultura local.
Evaluation of the mutagenic and antimuutagenic activity of Chlorella vulgaris in a test of Allium cepa
Authors: Messias Inalda Maria de Oliveira , Beltrão Gerusa Tomaz  de Aquino , Messias Júlio Brando , Ferreira Adriano Gomes , Oliveira Giselly Thais da Silva , Andrade Lúcio Arantes de , Caires Silvana de Fátima Ferreira da Silva , Bezerra Raquel Pedrosa , Marques Daniela Araújo Viana , Porto Ana Lúcia Figueiredo
Published: April 2022

The microalgae Chlorella vulgaris is usually commercialized as nutraceutical although it has potential application in the pharmaceutical and cosmetic industries. Therefore, our objective in this research is to evaluate the mutagenic and antimutagenic action of the aqueous extract of C. vulgaris through the Allium cepa assay. Three concentrations of the aqueous extract of C. vulgaris were tested: 0.075, 0.15 and 0.30mg/mL. In the mutagenicity analysis, A. cepa meristematic cells were cultured in the presence of the aqueous extract of C. vulgaris with distilled water as negative control and copper sulfate as positive control. For antimutagenicity, pre-treatment, simple simultaneous and post-treatment protocols were used. 400 cells/treatment were analyzed under optical microscopy (40x). Data were analyzed by ANOVA (one-way) and Tukey tests, considering p<0.05. The aqueous extract of C. vulgaris did not show mutagenicity in any of the three concentrations evaluated. About the antimutagenicity protocols, the harm reduction percentages were 94.7%, 94.1% and 96.2% (pre-treatment); 88.9%, 93.2% and 91.08% (simultaneous simple); and 85.2%, 84.5% and 94.7% (post-treatment) referring to concentrations of 0.075, 0.15 and 0.30 mg/mL, respectively. According to these results, the microalgae C. vulgaris did not show mutagenic action at the tested doses and it reduced genetic damage caused by copper sulfate.
Neoliberalismo, Consenso de Washington e Mídia Neoliberal: a tríade do desmonte da educação pública profissional e tecnológica (EPT)
Authors: Santos Gerônimo Vicente dos , Meirelles Nelson Vieira da Silva
Published: April 2022

O artigo aborda a influência da hegemonia dominante na educação pública brasileira, fundamentalmente na educação profissional e tecnológica (EPT), por meio do uso de três mecanismos do capitalismo para inibir qualquer possibilidade de educação pública e, especificamente, de ensino médio integrado. educação profissional, seja uma jornada para superar o dualismo formação intelectual versus formação manual e transformar as relações que provocam o fim da desigualdade educacional. Trata-se da tríade, neoliberalismo, sua célula denominada “Consenso de Washington” e a mídia neoliberal brasileira, conluio de interesses políticos e econômico-sociais que, no Brasil, país dependente do capital internacional, contribui para o desmonte do serviço público e especificamente da  educação pública e gratuita, para devorar o que resta das políticas públicas e assistenciais do Estado, obstruindo a efetivação dos direitos sociais e civis dos cidadãos garantidos no artigo 6º da Constituição Brasileira, promulgada em 5 de outubro de 1988. A Metodologia consiste de uma pesquisa qualitativa e bibliográfica com consultas a trabalhos que tratam de temas e também de análises de reportagens da mídia corporativa nacional, cujas narrativas atestam o abandono do ensino público e a apresentação do setor privado como solução para o caos visível causado. por esta estrutura do poder dominante. Nos últimos anos, a resistência da sociedade civil organizada impediu que o desmonte ocorresse em sua totalidade na educação pública e gratuita.
O uso da irrigação com água salina pode reduzir o déficit de forragem no Semiárido brasileiro?
Authors: Silva José Orlando Nunes da , Santos João Pedro Alves de Souza , Salvador Kaique Renan da Silva , Leite Renan Matheus Cordeiro , Aviz Rhaiana Oliveira de , Silva Nágila Sabrina Guedes da , Amaral Erison Martins , Leite Mauricio Luiz de Mello Vieira
Published: April 2022

No Semiárido brasileiro a produção de foragem é limitada, principalmente, pela elevada evapotranspiração, variabilidade na distribuição espaço temporal das chuvas, baixa capacidade de suporte forrageiro das pastagens nativas (caatingas) e reduzido uso de tecnologias de convivência com as secas, que configuram uma região com déficit hídrico na maior parte do ano. Nesse sentido, a irrigação pode contribuir para aumentar o aporte de forragem para os animais durante todo o ano, notadamente na época de estiagem. No entanto, em grande parte deste território, as águas subterrâneas e superficiais apresentam elevados teores salinos, o que pode ocasionar a salinização dos solos e dificultar o cultivo das plantas forrageiras. O entendimento dos efeitos dos sais, presentes na água de irrigação, no solo e nas plantas facilita o manejo e a mitigação dos níveis salinos nos solos. Nesse sentido, objetivou-se, nesta revisão, discorrer sobre os processos de formação dos solos salinos, efeitos dos sais nas plantas e no solo, mecanismos de tolerância das plantas e possíveis práticas de manejo que possibilitem o uso sustentável da irrigação com água salina em plantas forrageiras.
Leishmaniose visceral na região sul do Brasil: análise crítica frente a evolução epidemiológica
Authors: Dias Tábata Pereira , Versteg Nielle , Jardim Gabriela de Carvalho , Borges Laura Vieira , Leal Karine Bastos , Gressler Renata Pierobom , Figueiredo Fabiano Borges , Cleff Marlete Brum
Published: April 2022

A leishmaniose visceral (LV) foi considerada indene na região sul do país até 2006, quando houve a primeira notificação de caso autóctone canino no município de São Borja no Rio Grande do Sul. Nos estados de Santa Catarina e Paraná, a autoctonia em caninos ocorreu nos anos 2010 e 2012 respectivamente. Na região sul, por ser de instalação recente, além das poucas notificações, observa-se a falta da inclusão da enfermidade nos diagnósticos diferenciais na clínica humana e veterinária, sendo a prevalência da LV maior que o registro de casos notificados. Assim, objetivou-se revisar a situação da LV humana e canina (LVC) e a presença dos vetores na região sul do país. Foram consideradas publicações oficiais sobre a doença entre 2009 e 2020 e consultadas as bases de periódicos online. Foram encontradas informações conflitantes quanto ao número de casos e localidade da infecção, que podem ser consequência da mudança na padronização dos registros de LV humana, da descentralização e falta de uniformidade nos registros de LVC, além da divulgação dos diagnósticos através de boletins epidemiológicos anuais desatualizados. Requer atenção da vigilância e dos pesquisadores o flebotomíneo Lutzomyia gaminarai, espécie endêmica no sul do Brasil, pela proximidade filogenética com a Lutzomyia longipalpis.
A Enfermagem diante do letramento em saúde, alimentação e doenças crônicas não transmissíveis em pessoas idosas: revisão integrativa de literatura
Authors: Menezes Ariane Ferreira de , Tier Cenir Gonçalves , Santos Aline Ost dos , Oliveira Jamille Louise Bortoni de , Moura Cindy Byane de Melo de , Sauceda Mariana Ferreira de Menezes , Lana Letice Dalla , Abreu Daiane Porto Guatério , Cassola Talita Portela
Published: April 2022

Objetivo: identificar na literatura cientifica a atuação do enfermeiro relacionado ao letramento funcional em saúde de pessoas idosas com doenças crônicas não transmissíveis e sua relação com a alimentação adequada. Metodologia: Revisão integrativa de literatura realizada em fevereiro de 2022. Para a seleção dos artigos utilizou-se as seguintes bases de dados eletrônicas: Medical Literature Analysis and Retrievel System Online (MEDLINE) via National Library of Medicine (PubMed); Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) e Base de Dados de Enfermagem (BDENF) via Biblioteca Virtual em Saúde (BVS); Scientific Eletronic Library Online (Scielo); Web of Science; ScieVerse (Scopus). A definição da questão norteadora deste estudo se deu mediante a estratégia Population/Patient/Problem – Interest - Context, Time (PICoT): “Quais as evidências cientificas sobre o letramento funcional em saúde relacionado a alimentação adequada das pessoas idosas com doenças crônicas não transmissíveis e o papel do enfermeiro ?”.Resultados: Identificaram-se 4 estudos que evidenciaram o baixo nível de Letramento Funcional em Saúde em Idosos, tendo a idade e escolaridade como fatores primordiais. Conclusão: o planejamento de ações em saúde a fim de promover o letramento funcional em saúde é necessário para adesão e sucesso no tratamento salientando o papel da equipe de enfermagem neste processo.
Biochemical indicators of dairy cows affected by fermentative digestive disorders
Authors: Coutinho Luiz Teles , Mendonça Carla Lopes , Soares Gliere Silmara Leite , Conceição Ângela Imperiano da , Oliveira Filho Emanuel Felipe de , Silva Nivan Antonio Alves da , Souto Rodolfo José Cavaltanti , Cajueiro Jobson Filipe de Paula , Soares Pierre Castro , Afonso José Augusto Bastos
Published: April 2022

The purpose of the present study was to evaluate blood metabolites in dairy cows affected by digestive disorders of fermentative nature. Sixty-six animals with clinical and laboratory diagnoses were distributed into six groups according to the diagnosis: G1 (n=5) acute ruminal acidosis; G2 (n=10) displacement of the abomasum to the right (RDA); G3 (n=16) displacement of the abomasum to the left (LDA); G4 (n=10) cecal dilation; G5 (n=6) simple indigestion; and G6 (n=19) frothy bloat. Biochemical variables related to the energy, protein, enzymatic, mineral, and hormonal profile were measured soon after diagnosis and at the time of clinical resolution. The data were submitted to analysis of variance (ANOVA) with the level of significance set at 5%. Abnormalities were found with the fermentative digestive disorders, such as a negative energy balance (NEB), liver and muscle damage, and a high level of stress. Among the conditions diagnosed, abnormalities were more evident in acute ruminal acidosis, displacement of the abomasum (RDA), and cecal dilation. The biochemical abnormalities reflected the impact caused by the digestive disorders. Thus, understanding of the dynamics of biochemical abnormalities is fundamental to the establishment of the diagnosis, evaluation of the therapeutic response, and a more precise assessment of the prognosis, thereby avoiding greater economic losses in dairy farming activities and contributing to the improvement in the animal welfare.
Pesquisa em enfermagem no Brasil no contexto da pandemia COVID-19: revisão integrativa
Authors: Piubello Simone Martins Nascimento , Pereira Jéssica de Fátima Gomes
Published: April 2022

Objetivo: analisar a produção científica acerca da COVID-19 na área da enfermagem nos periódicos da área no Brasil. Materiais e Método: revisão integrativa de literatura, cuja busca foi norteada pela estratégia PICOT, sendo: P – Enfermagem; I – não se aplica; C – não se aplica; O – COVID-19; T – 2020-2021. Os estudos foram buscados na SciELO e BVS. Resultados: selecionaram-se 23 artigos disponíveis em inglês e português, publicados em periódicos nacionais. Quanto ao ano, 11 foram publicados em 2020 e 12, em 2021. Dividiram-nos em três categorias: (1) cuidados de enfermagem (n=11); (2) processo de trabalho da enfermagem (n=9); e (3) tecnologia para assistência de enfermagem na COVID-19 (n=3), quanto ao desenho do estudo, encontraram-se que a maioria era relato de experiência (56%) seguido por estudo metodológico (17%). Conclusão: os profissionais buscam fundamentar a prática assistencial em evidências científicas e, desta forma, encontraram-se diversas categorias de estudo, tanto artigos originais como reflexão, relatos de experiências e revisões, os quais contribuem para discussão e construção do conhecimento da enfermagem acerca da COVID-19.
Avaliação acerca do Zebrafish (Danio rerio) como modelo biomédico para determinação da toxicidade do dimesilato de lisdexanfetamina
Authors: Português Vivianne Rodrigues , Hermes Valquiria Weiller , Paulino Isabela Machado , Mendonça Beatrice Lemes , Martins Carlos Eduardo Cabral , Prado Filho Carlos Emanuel do , Margioti Natalia , Campos Vanessa Figueiredo , Carmo Vinicius Pereira do , Carmignan Françoise , Rivero-Wendt Carla Letícia Gediel
Published: April 2022

O zebrafish (ZF), de nome científico Danio rerio, é cada vez mais usado para realização de testes envolvendo a formação de circuitos neuronais, padrões de comportamento e neuropatogenia, que permitem a realização de estudos toxicológicos envolvendo o Sistema Nervoso Central. Dessa forma, fármacos que atuam em sistemas relacionados às monoaminas, como a dopamina e a serotonina - fundamentais na regulação das funções cerebrais em animais e humanos - podem ser melhor estudados a partir de métodos utilizando o ZF, o qual possui, componentes específicos para captar essas substâncias, permitindo sua avaliação. Nesse cenário, o Dimesilato de Lisdexanfetamina (DEX), um fármaco utilizado para tratamento de Transtorno do Déficit de Atenção e Hiperatividade (TDAH), possui propriedades capazes de atuar nos mecanismos reguladores das monoaminas, a fim de minimizar os déficits provocados pelo transtorno. Entretanto, devido a esses atributos, o DEX vem sendo utilizado por jovens e adultos hígidos, podendo trazer prejuízos devido a possíveis danos neurotóxicos. Com isso, este estudo objetiva por meio de uma revisão integrativa confirmar a aplicabilidade do modelo biomédico do ZF em avaliação de neurotoxicidade do DEX.