bluuebunny/crossref_metadata_2025 huggingface dataset:
A Case-Study of the Resources and Functioning of Two Research Ethics Committees in Western India
Authors: Chenneville Tiffany , Menezes Lynette , Kosambiya Jayendrakumar , Baxi Rajendra
Published: March 2016

Assessing the resources and functioning of research ethics committees (RECs) in low-resource settings poses many challenges. We conducted a case study of two medical college RECs (A and B) in Western India utilizing the Research Ethics Committee Quality Assurance Self-Assessment Tool (RECQASAT) as well as in-depth interviews with representative members to evaluate REC effectiveness. REC A and B obtained 62% and 67% of allowable points on the RECQASAT. These scores together with findings from the in-depth interviews suggest the need for significant improvement in REC effectiveness particularly in the areas of membership and educational training, organizational aspects, recording minutes, communicating decisions, and REC resources. Developing evidence-based best practices and strengthening infrastructure are essential to enhancing REC efficacy in low-resource countries.
Planning for Ancillary Care Provision
Authors: Jacobson Nora , Krupp Anna , Bowers Barbara J.
Published: March 2016

As part of a study designed to assess a new strategy for increasing health research participation by members of underrepresented populations in the United States, we explored expectations about volunteering for research among people from lower income and largely minority communities in Madison, Wisconsin. Members of these communities often saw research participation as a means to access health care that might otherwise be unavailable to them. In light of persistent structural barriers to access, and the resulting health disparities, we argue that one cannot assume the existence of a “fair exchange” in which a community is likely to benefit from the results of research conducted with members of that community. We use ethical analysis and empirical research conducted in the developing world to explore how investigators in the United States might think about their obligations to provide ancillary care.
The Ambassadors and the Afterlife of Failure
Authors: Bartlett Jami
Published: March 2016

This essay argues that Henry James’s novel The Ambassadors and his essay “Is There a Life After Death?” are similarly structured around the pleasures of half-belief in a doomed enterprise.
The Construction of Racial Identity among Same Gender Loving Black Male Characters in Contemporary Film and Television
Authors: Copeland Kameron J.
Published: March 2016

The mainstream media has historically characterized Black male sexuality with hypersexual images of violence, promiscuity, and insecurity. While traditional representations of Black male sexuality contains elements of dehumanization and objectification, the recent introduction of Black same gender loving ( sgl ) male characters to film and television has been branded by stereotypical notions on Black masculinity. The modern American Gay Rights Movement’s lack of influential Black male leaders has catalyzed the production of one-dimensional Black sgl male characters without extensive racial identities. The foregoing study examines the link between Black sgl men and their racial identities through analyzing the representation of homophobia and the downlow, the portrayal of interracial homosexual relationships involving Black men, and the depiction of intraracial Black sgl male relationships and their expressions of cultural norms.
The Role of Resilience and Anti-Resilience Behaviors in the Romantic Lives of Black Same Gender Loving (SGI) Men
Authors: Applewhite Sheldon , Littlefield Marci Bounds
Published: March 2016

This study examines the role of resilience in the romantic lives of Black same gender loving romantic male couples in the nyc metropolitan area. Twenty indepth interviews (N=40) were conducted, ranging in age from 18 to 67, and were predominately low income and moderately educated. Research questions were: 1) What strategies do Black sgl couples use to preserve and improve their relationships and (2) What are the potential problems or barriers your relationship experiences? The data from interviews were aggregated and three major themes emerged: direct communication strategies, relationship support, and intentional and thoughtful decision making. Additional themes identified as anti-resilient to Black sgl couples were relationship discord, hostile neighborhood climate, poor communication, and lack of support. Findings show that additional research Black gay couples is needed to identify the contextual factors that influence their romantic relationships and the resilient strategies that they uses to support their romantic relationships.
Mach principle based explanation for the â€˜cosmological red-shiftâ€™ and itâ€™s evidence
Authors: K. Tank Hasmukh
Published: March 2016

We first find here that the ratio of: (loss in energy of cosmologically red-shifting photon) and (loss in electrostatic potential-energy of an electron at the same distance D) remains equal to the famous ratio (G me mp) / e2 leading us towards a possibility that â€˜cosmological red-shiftâ€™ may be due to gravitational effect. Also the ratio h H0 / me c2 = (G me mp) / e2. Starting with Machâ€™s principle, that â€˜massâ€™ of an object is because of its â€˜cosmic gravitational potential energyâ€™, we arrive at a possibility that every moving chunk of matter and energy should experience a fixed value of acceleration H0 c. For the purpose of comparison, we express the â€˜cosmological red shiftâ€™ as deceleration of the photon, and find that the deceleration experienced by the photon matches perfectly with the expected value. Then it is argued that if such a deceleration is true for a chunk of energy called photon, then it must be true for every particle of matter too. Strikingly, the decelerations experienced by the space-probes Pioneer-10, Pioneer-11, Galileo and Ulysses, as carefully measured by Anderson J.D. ET. Al. Match perfectly with the deceleration of the â€˜cosmologically red-shifting photonsâ€™; thus providing supportive evidence for the new explanation proposed here.
REVERSE LOGISTICS OF AGROCHEMICAL PESTICIDE PACKAGING AND THE IMPACTS TO THE ENVIRONMENT
Authors: Mello Mario Fernando , Scapini Rosangela
Published: March 2016

Abstract: Over time, agriculture has proven to be an important economic development factor for Brazil. The evolution and the need for productivity caused a large increase in the use of pesticides in agriculture and with it, the need to give proper treatment to packaging. With these agricultural activities in evidence, it is not possible to keep the crops without the use of pesticides. In 2000, it was created the 9,974 law as a decree Law 4,074/2002, which regulates the reverse logistics of empty containers of pesticides. This study intends to demonstrate that there are still producers who have difficulties in finding the correct destination to pesticide containers because of lack of knowledge of the law or because they acquire chemicals illegally, without a specific origin. The instruments for protecting the environment, such as licensing and environmental legislation stand out as high points, since it has the general objective of analyzing and demonstrating how reverse logistics helps minimize the impact and the possible environmental and health problems caused by the incorrect disposal of pesticide containers of and along with a group of farmers.
RUBRIC FOR THE ASSESSMENT THE COMPETENCE OF INNOVATION CREATIVITY AND ENTREPRENEURSHIP IN BACHELOR DEGREE
Authors: Cuenca Llanos , Alarcón Faustino , Boza Andrés , Fernández-Diego Marta , Ruiz Leonor , Gordo MariLuz , Poler Raul , Alemany M.M.E.
Published: March 2016

Innovation has a special value for the survival and development of organizations, especially in a changing context. The development of innovation capacity in students enhances their capacity to enter the workforce. A competency describes what training participants should be able to do at the end of the training. The competence is acquired through various learning outcomes to be achieved. Competition in innovation is closely related to the ability to propose and implement creative ideas to solve problems, ability to create and maintain connections work, etc. In this article is presented a method for measuring the competence of innovation creativity and entrepreneurship in bachelor degree by introducing different levels of scope.
DIAGNOSIS FOR THE IMPLEMENTATION OF AN ENVIRONMENTAL MANAGEMENT SYSTEM IN A MICROBUSINESS IN THE URBAN VECTOR AND PEST CONTROL SECTOR
Authors: Ribeiro Renata Maciel , Barros Sergio Ricardo , Wasserman Julio Cesar , Franz Barbara
Published: March 2016

This project analyzes and discusses the application of a methodological valuation model of an environmental maturity of a company of vectors and pests control. The method used was the initial environmental diagnostics, which intended to classify in a scale of values the Business Process of the company to Certification based on NBR ISO 14001. As a result of the application of the method were identified EMS Critical Success Spots low performed by the company, and the positive influence of ISO 9001 Certification already established in the organization. As well as, proposed actions to improve the weaknesses that were identified by the diagnostics in order to establish a schedule for the compliance of the first phase of the PDCA method proposed by the ISO 14001.
L1 Retrotransposons Are Transcriptionally Active in Hippocampus of Rat Brain
Authors: Mukherjee Somnath , Sharma Deepak , Upadhyaya Kailash C.
Published: March 2016

LINE1 (L1) is an autonomous, non-LTR retrotransposon and the L1 family of retrotransposons constitute around 17%, 20% and 23% in the human, mouse and rat genomes respectively. Under normal physiological conditions, the retroelements remain by and large transcriptionally silent but are activated in response to biotic and abiotic stress conditions and during perturbation in cellular metabolism. They have also been shown to be transiently activated under certain developmental programs. Using RT-PCR, we show that the L1 elements are transcriptionally active in the hippocampus region of the brain of four-month-old rat under normal conditions without any apparent stress. Twenty non-redundant LINE1-specific reverse transcriptase (RTase) sequences form ORF2 region were isolated, cloned and sequenced. Full length L1 element sequences complementary to the isolated sequences were retrieved from the L1 database. In silico analysis was used to determine the presence of these retroelements proximal (up to 10 kb) to the genes transcriptionally active in the hippocampus. Many important genes were found to be in close proximity of the transcriptionally active L1 elements. Transcriptional activation of the elements possibly affects the expression of the neighbouring genes.
Terlipressin Induced Severe Hyponatremia
Authors: Šíma Martin , Pokorný Miroslav , Paďour František , Slanař Ondřej
Published: March 2016

Terlipressin is a vasopressin analogue used for its vasoconstrictor effect in the treatment of variceal bleeding. Despite its good safety profile compared to vasopressin, some adverse reactions may occur during its use – e.g. hyponatremia. We describe a case of a cirrhotic patient with active variceal bleeding treated during two separate hospitalizations with terlipressin. In both drug treatment periods, severe laboratory hyponatremia developed. After terlipressin discontinuation, mineral disbalance corrected rapidly. Positive dechallenge and rechallenge corresponding to the drug administration schedule confirms the causality between terlipressin administration and hyponatremia. Hyponatremia was preceded with substantial fluid retention in both episodes. In this case report we want to highlight the need for fluid balance monitoring immediately after first terlipressin dose, which may individually predict the patient risk for the development of hyponatremia as other risk factors have rather limited predictive value in real clinical settings.
Uniqueness of solutions to singular p-Laplacian equations with subcritical nonlinearity
Authors: Maultsby Bevin
Published: March 2016

We present a geometric approach to the study of quasilinear elliptic p-Laplacian problems on a ball in

ℝ
n

${\mathbb{R}^{n}}$

using techniques from dynamical systems. These techniques include a study of the invariant manifolds that arise from the union of the solutions to the elliptic PDE in phase space, as well as variational computations on two vector fields tangent to the invariant manifolds. We show that for a certain class of nonlinearities f with subcritical growth relative to the Sobolev critical exponent

p
*

${p^{*}}$

, there can be at most one such solution satisfying

Δ
p

⁢
u

+

f
⁢

(
u
)

=
0

${\Delta_{p}u+f(u)=0}$

on a ball with Dirichlet boundary conditions.
Inverse source problem based on two dimensionless dispersion-current functions in 2D evolution transport equations
Authors: Hamdi Adel , Mahfoudhi Imed
Published: March 2016

The paper deals with the nonlinear inverse source problem of identifying an unknown time-dependent point source occurring in a two-dimensional evolution advection-dispersion-reaction equation with spatially varying velocity field and dispersion tensor. The originality of this study consists in establishing a constructive identifiability theorem that leads to develop an identification method using only significant boundary observations and operating other than the classic optimization approach. To this end, we derive two dispersion-current functions that have the main property to be of orthogonal gradients which yield identifiability of the elements defining the involved unknown source from some boundary observations related to the associated state. Provided the velocity field fulfills the so-called no-slipping condition, the required boundary observations are reduced to only recording the state on the outflow boundary and its flux on the inflow boundary of the monitored domain. We establish an identification method that uses those boundary records (1) to localize the sought source position as the unique solution of a nonlinear system defined by the two dispersion-current functions, (2) to give lower and upper bounds of the total amount loaded by the unknown time-dependent source intensity function, (3) to transform the identification of this latest into solving a deconvolution problem. Some numerical experiments on a variant of the surface water BOD pollution model are presented.
Daganatos betegekben kialakult másodlagos nyiroködéma ellátása
Authors: Wenczl Enikő
Published: March 2016

Due to the increased number of cancer patients and the progress in cancer treatment, there are more cases with cancer-related lymphedema. Lymphedema treatment became part of oncological patients’ care. Basic therapy for lymphedema is the complex decongestive therapy, which should be embedded into the patient’s comprehensive medical care and should always be determined individually. Results of therapy are influenced by the experience of the doctor and the physiotherapist in lymphedema care, patient’s complience, tumor behavior and the accompanying diseases. Lymphedema is a chronic disease, requires lifelong follow-up and treatment. For prevention and better care, it would be important to inform patients about lymphedema risk and appropriate life-style (e.g. weight control) preoperatively and during oncological follow-up. Early diagnosis is important. Lymphedema treatment should be integrated into palliative programmes. If therapy is started in time, complications may be avoided, healthcare costs may be reduced and better quality of life may be achieved. Orv. Hetil., 2016, 157(13), 488–494.
Aszimmetrikus dimetilarginin: a cardiovascularis betegségek prediktora?
Authors: Németh Balázs , Kustán Péter , Németh Ádám , Lenkey Zsófia , Cziráki Attila , Kiss István , Sulyok Endre , Ajtay Zénó
Published: March 2016

Cardiovascular diseases are the most common diseases worldwide. They are responsible for one third of global deaths and they are the leading cause of disability, too. The usage of different levels of prevention in combination with effective risk assessment improved these statistical data. Risk assessment based on classic risk factors has recently been supported with several new markers, such as asymmetric dimethylarginine, which is an endogenous competitive inhibitor of nitric oxide synthase. Elevated levels of asymmetric dimethylarginine have been reported in obese, smoker, hypercholesterolemic, hypertensive and diabetic patients. According to previous studies, asymmetric dimethylarginine is a suitable indicator of endothelial dysfunction, which is held to be the previous state of atherosclerosis. Several researches found positive correlation between higher levels of asymmetric dimethylarginine and coronary artery disease onset, or progression of existing coronary disease. According to a study involving 3000 patients, asymmetric dimethylarginine is an independent risk factor of cardiovascular mortality in patients with coronary artery disease. This article summarizes the role of asymmetric dimethylarginine in prediction of cardiovascular diseases, and underlines its importance in cardiovascular prevention. Orv. Hetil., 2016, 157(13), 483–487.
Periodontitis subject with failing dentition and management with cross arch bridge and implants
Authors: Durrani Farhan
Published: March 2016

Severe periodontal disease often leads to tooth loss, necessitating prosthetic rehabilitation to restore function and aesthetics. The concept of perio-prosthetic treatment using extensive bridges of cross-arch design was introduced approximately 30 years ago. Long term follow-up studies have shown that teeth with reduced periodontal support can be used as abutments for extensive fixed prostheses, provided periodontal disease had been treated successfully and an effective recall program had been instituted to prevent periodontal disease recurrence. Implants along with cross arch bridges in controlled periodontitis subject have never been used together for complete full mouth rehabilitation.
Ileostomy closure in a patient with severe pulmonary hypertension and COPD - Anaesthetic consideration
Authors: Garg Ankur , Engineer Smita R. , Patel Kiran
Published: March 2016

High morbidity and mortality occur in patients with pulmonary hypertension (PH) undergoing non-cardiac surgery under any type of anaesthesia technique. Right heart failure occurs due to increased pressure in pulmonary artery secondary to pain, stress and ventilation. It is important to maintain preload, ventricular contractility, pulmonary vascular resistance and right ventricular afterload. It is also necessary to avoid hypoxia, hypercarbia, hypothermia and pain. A 45 year old male patient, known case of chronic obstructive pulmonary disease (COPD) with severe PH was posted for ileostomy closure. General anaesthesia (GA) with epidural catheter for analgesia was given.
Pigmented villonodular synovitis of hip treated by uncemented total hip arthroplasty: a case report
Authors: Sau Saikat , Bishwas Chinmoy
Published: March 2016

Pigmented villonodular synovitis (PVNS) is rare, benign proliferative disorder of the synovium of unknown origin. It is commonly seen in knee joint but hip, ankle, shoulder, wrist & other joints can be involved. It is usually seen in young adults from 20-50 years of age. It is seen more in men than women. PVNS potentially locally aggressive disease that should be considered in younger patients who present with monoarticular joint symptoms and pathology. As per literature treatment of PSVN is total synuvectomy, specially for big joint can be replaced. Chance of recurrence is not rare. Radiation can help in recurrence case. We are presenting case of 34 years male patient with right hip pain and degenerative changes. After total hip replacement 3years follow up he has no complain still now.
Efeito de diferentes tratamentos de polinização em berinjela em casa de vegetação
Authors: Silva M. A. , Oliveira F. A. , Hrncir M.
Published: March 2016

O presente trabalho objetivou avaliar a influência de diferentes tipos de polinização na quantidade e qualidade de berinjela (Solanum melongena) cultivada em casa de vegetação. A pesquisa foi realizada em uma casa de vegetação localizada na Universidade Federal Rural do Semiárido (UFERSA), Mossoró/RN. Foram utilizadas duas colônias de Scaptotrigona sp. Para verificar os requerimentos de polinização foram realizados quatro tratamentos: polinização livre, autopolinização, polinização manual por vibração e polinização cruzada manual, comparando a quantidade e qualidade dos frutos obtidos de cada tratamento, como peso, comprimento, circunferência e número de sementes produzidas. O tratamento de polinização cruzada manual (PCM) apresentou os maiores valores em relação a número de frutos produzidos (26,67%) e com maior número de sementes (1º corte: 3,2 ± 10,12; 2º corte: 26,7 ± 27,91; 3º corte: 103,4 ± 21,79) quando comparados com os demais tratamentos, entretanto o peso, comprimento e circunferência dos frutos não diferiram entre os tratamentos. A Scaptotrigona sp. não visitou as flores durante o período em que foram mantidas na casa de vegetação, porém são necessários mais estudos para determinar o verdadeiro potencial de Scaptotrigona sp. como polinizador de culturas em casa de vegetação.

Effect of different pollination treatment in eggplant in a greenhouse

Abstract: This study aimed was to evaluate the influence of different types of pollination in the quantity and quality of eggplant grown under greenhouse conditions and the behavior of Scaptotrigona sp. in a greenhouse. The survey was conducted in a greenhouse located on the Universidade Federal do Semiárido (UFERSA), Mossoró/RN. They used two colonies of Scaptotrigona sp. To check the pollination requirements in both cultures four treatments were performed: open pollinated, selfpollination, manual pollination by vibration and manual cross-pollination by comparing the quantity and quality of fruit from each treatment, such as weight, length and circumference and number of seeds produced. The manual cross-pollination treatment (PCM) had the highest values regarding the number of fruit (26,67 %) and more seeds (1º corte: 3,2 ± 10,12; 2º corte: 26,7 ± 27,91; 3º corte: 103,4 ± 21,79) when compared to other treatments, however the weight, length and circumference of the fruits did not differ between treatments. The Scaptotrigona sp. did not visit flowers during the period in which they were kept in the greenhouse however more studies are needed to determine the true potential of Scaptotrigona sp. as pollinator of crops in the greenhouse.
Influência da profundidade e posição de semeadura na emergência de Acacia polyphylla DC.
Authors: Rodrigues A. J. , Batista E. M. C. , Oliveira L. M. , Portella A. C. F. , Souza P. B.
Published: March 2016

A Acacia polyphylla DC. é uma leguminosa, pertencente à família Fabaceae, conhecida principalmente por monjoleiro, cuja árvore apresenta porte médio e rápido crescimento, a mesma enquadra-se em estágios iniciais da sucessão secundária com grande potencial para o uso na recuperação de áreas degradadas do Bioma Cerrado. Assim, objetivou-se avaliar a influência de diferentes posições e de profundidades de semeadura na emergência e crescimento inicial de plântulas de Acacia polyphylla DC. O experimento foi realizado em delineamento inteiramente casualisado, com quatro repetições de 25 sementes, dispostos em esquema fatorial 3 x 5 (posições e profundidades de semeadura). Os tratamentos consistiram em diferentes posições das sementes no substrato: hilo voltado para cima, hilo voltado para baixo e sementes na horizontal, nas profundidades de 1, 2, 3, 4 e 5 cm. Determinou-se a porcentagem de emergência, índice de velocidade de emergência, bem como o comprimento e a massa seca da parte aérea e da raiz das plântulas. A emergência e o crescimento inicial das plântulas de Acacia polyphylla DC são afetadas pelas posições e profundidades de semeaduras, sendo que o procedimento ideal para o plantio e desenvolvimento das plântulas deve ser em uma profundidade entre 1,4 e 2,8 cm com o hilo na posição horizontal.

Influence of depth and sowing position in the emergency Acacia polyphylla DC.

Abstract: Acacia polyphylla DC. is a legume belonging to the Fabaceae family, mainly known for monjoleiro whose tree has medium size and rapid growth, it fits in the early stages of secondary succession with great potential for use in the recovery of degraded areas of the Cerrado Biome. The objective was to evaluate the influence of different positions and sowing depths in the emergence and early growth of seedlings Acacia polyphylla DC. The experiment was conducted in completely randomized design with four replications of 25 seeds, arranged in a factorial 3 x 5 (positions and sowing depths). The treatments consisted of different positions of the seeds in the substrate: hilum facing up, hilum facing down and seeds horizontally at depths of 1, 2, 3, 4 and 5 cm. It was determined the percentage of emergence, emergence speed index, as well as the length and dry weight of shoot and root of seedlings. The emergence and early growth of seedlings Acacia polyphylla DC. are affected by the positions and sowing depths, and the ideal procedure for planting and seedling development must be at a depth between 1.4 and 2.8 cm, with the hilum in horizontal position.
Influence of iron deficiency on thyroidal hormone production in piglets before weaning
Authors: Fajt Zdeněk , Baňoch Tomáš , Vašek Jan , Vaňhara Jonáš , Blahová Jana , Kazatelová Zdenka , Fiorino Emma , Svoboda Martin
Published: March 2016

The aim of this study was to evaluate the influence of iron deficiency on the thyroidal function and hormone T3 and T4 concentration in piglets before weaning. We used 40 Landrace × Czech Large White piglets before weaning in this trial. They were divided into two groups. The control group was supplemented with iron after birth, the experimental group was without iron supplementation after birth. Iron, T3 and T4 and haematology indicators were observed. Piglets in the experimental group developed serious anaemia. The iron serum concentration in the experimental group was significantly lower than in the control group. Significant difference in T3 and T4 hormone concentration was found between the experimental and the control group. At the age of 17 and 25 days we found the negative effect of iron deficiency on the thyroid hormone production.
The concentrations of selected blood serum proteins in calves during the first three months of life
Authors: Tóthová Csilla , Nagy Oskar , Nagyová Veronika , Kováč Gabriel
Published: March 2016

This study was aimed at the evaluation of changes in the concentrations of selected blood serum proteins in calves during the first three months of life, including precolostral, colostral, milk, transitional and solid feeding period. Nine clinically healthy calves were used in this study. The first blood sampling was performed before the colostrum intake (day 0) and then at 1, 2, 7, 14, 30, 60, and 90 days of age. Blood serum was analyzed for the concentrations of α1-fetoprotein, prealbumin, transferrin, and lactoferrin. The results showed significant changes in the serum concentrations of all the evaluated proteins in calves during the first three months of life (P < 0.01 and P < 0.001). At birth, the mean concentration of α1-fetoprotein was low and increased more than × 8 at one day after colostrum intake, then a gradual decrease was found up to day 30 of life. Similar tendency was observed in the concentrations of prealbumin and lactoferrin. While the concentrations of prealbumin increased approximately × 3.5 at one day after colostrum intake, the serum lactoferrin values showed approximately 1.5-fold increase. A subsequent gradual decrease from the 2nd day of life was found for both prealbumin and lactoferrin. In the concentrations of transferrin, a significant increase was observed on day 7 (P < 0.05). The highest values were found at the age of 14 and 30 days. These results suggest that concentrations of these proteins in calves are markedly altered during the postnatal period, which should be taken into consideration for their precise interpretation in young animals.
Three-dimensional bone tissue substitute based on a human mesenchymal stem cell culture on a nanofiber carrier and inorganic matrix
Authors: Krbec Martin , Plíštil Lukáš , Matoušková Eva , Mandys Václav , Ježek Jakub , Sedlinská Markéta , Džupa Valér
Published: March 2016

The aim was to construct a composite structure for bone tissue substitute on the basis of a degradable composite of an organic nanofiber carrier and an inorganic matrix in 3D, and to achieve subsequent colonisation by differentiated human mesenchymal stem cells (hMSC) towards osteocytes. We developed an active bone tissue substitute using nanofiber technology for a polycaprolactone (PCL) scaffold with the addition of hydroxyapatite and the colonisation of both components with hMSC with the ability of differentiation towards osteocytes. The constructed composition included the components necessary for bone healing (inorganic and cellular) and it also forms a spatially-oriented 3D structure. We used polycaprolactone Mw 70,000 with electrostatic spinning for the formation of nanofibers using a modified NanospiderTM method. For the inorganic component we used orthophosphate-calcium silicate with a crystal size of 1-2 mm which the nanofiber membrane was coated with. Both components were connected together with a tissue adhesive based of fibrin glue. Cultivated hMSC cells at a concentration of 1.2 × 104/cm2 were multiplied in vitro and then cultivated in the expansion medium. HMSC overgrew both the PCL membrane and the Si-CaP crystals. After colonisation with cultivated cells, this composite 3D structure can serve as a three-dimensional bone tissue replacement.
Changes of lidocaine concentration and physiological indices in dogs during anaesthesia with lidocaine and isoflurane combined with ketamine or fentanyl
Authors: Zhang Shi-Xia , Li Xin , Ren Qing-Ming , Niu Dong-Liang , Gao Li , Wang Hong-Bin
Published: March 2016

Fentanyl and ketamine are often used as adjuvants in intravenous anaesthesia to prolong analgesia. The aim of this study was to compare changes of the basic physiological variables of intravenous lidocaine administration in combination with ketamine or fentanyl, and to evaluate the impact of addition of fentanyl or ketamine to lidocaine on serum lidocaine concentrations in dogs after intravenous administration. During general anaesthesia, dogs of group L received 2% lidocaine intravenously, dogs of group LF received 2% lidocaine and fentanyl, and dogs of the group LK received 2% lidocaine and ketamine. The heart rate, systolic arterial pressure, diastolic arterial pressure, mean arterial pressure and rectal temperature decreased in all groups, and group LF showed the biggest effect on the basic physiological variables, with the lowest heart rate during the test, significantly decreased rectal temperature, and the most decreased values of arterial pressure. Blood for determination of serum lidocaine concentration was taken before anaesthesia and 5, 30, 60, 90, 120, 150 and 180 min after initial intravenous injection of drugs. Fentanyl and ketamine did not cause significant changes of serum lidocaine concentration in dogs and may be used as adjuvant in intravenous anaesthesia without a significant increase in lidocaine absorption.
Pharmacological evaluation of methanolic extract of Cyperus scariosus
Authors: Khan Wasi Ullah , Khan Rahmat Ali , Ahmed Mushtaq , Khan Latif Ullah , Khan Muhammad Waqas
Published: March 2016

The present study is aimed to investigate the phytochemical screening and biological activities of methanolic extract of Cyperus scariosus roots. Dried plant was grounded and extracted with methanol to prepare methanol crud extract. In vitro biological tests were conducted using this methanolic extracts according to the standard procedure. 100% death rate of brine shrimp was perceived at 3 mg/mL of plant extract after 72 hours. The extract showed action against Aspergillus flavius i.e. 90% followed by A. niger (91%) while the highest activity was shown against A. fumegatrus (94%). Important scavenging results were detected during scavenging of free radicals viz; 92.2% against DPPH, 82.2% to ABTS, 75.8% to hydrogen peroxide, 88.1% to β-carotene, 86.1% to hydroxyl radical and 89.4% against phosphomolybdate at 3 mg/mL were obtained. The results obtained in this study point out that extract showed significant biological activities which might be due to the presence of bioactive constituents.

 
Quality Issues of Research Antibodies
Authors: Weller Michael G.
Published: March 2016

According to several recent studies, an unexpectedly high number of landmark papers seem to be not reproducible by independent laboratories. Nontherapeutic antibodies used for research, diagnostic, food analytical, environmental, and other purposes play a significant role in this matter. Although some papers have been published offering suggestions to improve the situation, they do not seem to be comprehensive enough to cover the full complexity of this issue. In addition, no obvious improvements could be noticed in the field as yet. This article tries to consolidate the remarkable variety of conclusions and suggested activities into a more coherent conception. It is concluded that funding agencies and journal publishers need to take first and immediate measures to resolve these problems and lead the way to a more sustainable way of bioanalytical research, on which all can rely with confidence.
Insights into Newer Antimicrobial Agents against Gram-negative Bacteria
Authors: Yaneja Neelam , Kaur Harsimran
Published: March 2016

Currently, drug resistance, especially against cephalosporins and carbapenems, among gram-negative bacteria is an important challenge, which is further enhanced by the limited availability of drugs against these bugs. There are certain antibiotics (colistin, fosfomycin, temocillin, and rifampicin) that have been revived from the past to tackle the menace of superbugs, including members of Enterobacteriaceae, Acinetobacter species, and Pseudomonas species. Very few newer antibiotics have been added to the pool of existing drugs. There are still many antibiotics that are passing through various phases of clinical trials. The initiative of Infectious Disease Society of America to develop 10 novel antibiotics against gram-negative bacilli by 2020 is a step to fill the gap of limited availability of drugs. This review aims to provide insights into the current and newer drugs in pipeline for the treatment of gram-negative bacteria and also discusses the major challenging issues for their management.
Early Programming by Protein Intake: The Effect of Protein on Adiposity Development and the Growth and Functionality of Vital Organs
Authors: Luque Veronica , Closa-Monasterolo Ricardo , Escribano Joaquín , Ferré Natalia
Published: March 2016

This article reviews the role of protein intake on metabolic programming early in life. The observations that breastfeeding in infancy reduces the risk of being overweight and obese later in life and the differences in the protein content between formula milk and human milk have generated the early protein hypothesis. The present review focuses on a mechanistic approach to programmed adiposity and the growth and development of other organs by protein intake in infancy, which may be mediated by branched-chain amino acids, insulin, and insulin-like growth factor 1 via the mammalian target of rapamycin. Observational studies and clinical trials have shown that lowering the protein content in infant and follow-on formulas may reduce the risk of becoming obese later in life. The recent body of evidence is currently being translated into new policies. Therefore, the evolution of European regulatory laws and recommendations by expert panels on the protein content of infant and follow-on formulas are also reviewed. Research gaps, such as the critical window for programming adiposity by protein intake, testing formulas with modified amino acids, and the long-term consequences of differences in protein intake on organ functionality among well-nourished infants, have been identified.
Don't you forget about me! The 80s still matter!
Authors: Cox Justin , Henry Timothy D.
Published: March 2016

Key Points

Invasive therapy had a significantly lower odds ratio of death at 28 days in elderly patients

Patients treated with a conservative approach received significantly less guideline directed medical therapy

The highest risk (those most likely to benefit) were less likely to get invasive therapy
ChemInform Abstract: STRUKTURELLE UND SPEKTROSKOPISCHE UNTERSUCHUNGEN AM BA2CUTEO6
Authors: KOEHL P. , REINEN D.
Published: March 2016

Die röntgenographische Einkristall‐Strukturuntersuchung zeigt, daß Ba2CuTeO6 bei Zimmertemperatur in einer triklinen Jahn‐Teller‐Variante des hexagonalen Ba2NiTeO6‐Typs (12‐Schichten‐Struktur) kristallisiert mit P1¯‐Ci1 a = 5,72, b = 5,86, c = 10,19 Å, α = 107,9°, β = 1O6,2°, γ = 60,7° und Z=2.
ChemInform Abstract: THERMODYNAMIC PROPERTIES OF NICKEL‐SELENIUM ALLOYS
Authors: JELINEK H. , KOMAREK K. L.
Published: March 2016

Die Dampfdrücke von Se in Ni‐Se‐Legierungen werden nach einer isopiestischen Methode zwischen 450 und 1000° und 45 und 66,6 Atom‐% Se bestimmt.
ChemInform Abstract: ION‐SOLVENT INTERACTIONS AS STUDIED BY PROTON MAGNETIC RESONANCE PART 2, ZNCL2 IN ETHANOL, METHANOL AND WATER
Authors: KARCZEWSKA IWONA , KECKI ZBIGNIEW
Published: March 2016

Die‐Abhängigkeit der chemischen Verschiebung der OH‐Gruppe von der Temperatur und der Konzentration der ZnCl2‐Lösungen in Äthanol, Methanol und Wasser wird untersucht.
ChemInform Abstract: PLATZWECHSELVORGAENGE DER LIGANDEN IN FESTEN KOMPLEXSALZEN 1. MITT. INTRAMOLEKULARE ISOMERISIERUNG AN GEMISCHTEN HEXAHALOGENOKOMPLEXEN VON OSMIUM(IV)
Authors: PREETZ W. , NADLER J. P.
Published: March 2016

Die Isomerisierung reiner fester Komplexe des Typs cis‐ bzw. trans‐K2 [OsClnY6‐n], Y = Br, J: n = 2,3,4, wird bei 1 15, 125 und 135°C mit Hilfe spektrophotometrischer Messungen verfolgt.
ChemInform Abstract: PLATZWECHSELVORGAENGE DER LIGANDEN IN FESTEN KOMPLEXSALZEN 2. MITT. INTERMOLEKULARER LIGANDENAUSTAUSCH IN GEMISCHTEN HEXAHALOGENOKOMPLEXEN VON OSMIUM(IV)
Authors: PREETZ W. , NADLER J. P.
Published: March 2016

Beim Tempern eines reinen Komplexsalzes vom Typ K, [OsC1nY6‐n], Y = Br, J ; n = 1‐5 auf 170 ‐200°C bilden sich durch intermolekulare Festkörperaustauschreaktionen alle Komplexe von n = 0‐6. Im Gleichgewichtszustand verteilen sich die Liganden statistisch über alle Spezies des Systems.
ChemInform Abstract: DAS DIMERISIERUNGSGLEICHGEWICHT 2 TICL(3,G)=TI2CL(6,G)
Authors: SIBBING ENGELBERT , SCHAEFER HARALD
Published: March 2016

Die Dimerisierung des gasförmigen Titan(III)‐chlorids wurde in Gegenwart eines TiCl4‐ Überschusses mit einer statischen Methode (Gold als Manometerflüssigkeit) gemessen.
ChemInform Abstract: PREPARATION OF HALIDE SULPHIDES AND HALIDE SELENIDES OF MOLYBDENUM AND TUNGSTEN
Authors: BRITNELL DAVID , FOWLES GERALD W. A. , RICE DAVID A.
Published: March 2016

Verschiedene Darstellungsmethoden von Halogenidsulfiden und ‐seleniden von Mo und W in verschiedenen Oxidationszuständen der Metalle werden untersucht.
ChemInform Abstract: NITROXIDE RADICALS PART 14, DECOMPOSITION OF 1‐ AND 2‐NAPHTHYL T‐BUTYL NITROXIDES
Authors: CALDER ALAN , FORRESTER ALEXANDER R. , MCCONNACHIE GORDON
Published: March 2016

2‐Naphthyl‐tert.‐butyl‐nitroxid und seine Substitutionsprodukte (8‐Methyl‐, 8‐tert.‐Butyl‐, 6‐Methoxy‐, 4,5‐Dimethyl‐) sowie 1‐Naphthyl‐tert.‐butyl‐nitroxid werden sowohl in reiner Form als auch als Lösungen in Benzol 14 Tage lang bei 30°C im Dunkeln der spontanen Zersetzung überlassen.
ChemInform Abstract: CLEAVAGE OF THE SILICON‐VINYL CARBON BOND BY FLUORIDE ION, AN UNEXPECTED BETA‐HYDROXY EFFECT
Authors: CHAN T. H. , MYCHAJLOWSKIJ W.
Published: March 2016

Aus den Silyl‐vinyl‐Verbindungen (I) erhält man bei Behandlung mit Fluorid‐Ionen, z.B. entsprechenden Tetraalkylammoniumfluoriden, in DMSO die Olefine (II) und Silanole (III).
ChemInform Abstract: AMINE FORMATION IN THE THERMODECOMPSITION OF DIARYLTITANOCENES IN THE PRESENCE OF DINITROGEN
Authors: SHUR V. B. , BERKOVITCH E. G. , VASILJEVA L. B. , KUDRYAVTSEV R. V. , VOL'PIN M. E.
Published: March 2016

Beim Erhitzen der Diphenyl‐ und Ditolyltitanocene (I) unter einem Stickstoffdruck von 80 ‐ 100 atm.
ChemInform Abstract: PROMOTING EFFECTS OF MOLECULAR NITROGEN ON THE ISOMERIZATION OF 1‐PENTENE CATALYZED BY HYDRIDODINITROGEN TRIS‐(TRIPHENYLPHOSPHINE)‐COBALT
Authors: PENNELLA F.
Published: March 2016

Die Isomerisierungsreaktion von Penten‐(1) (III) zu Penten‐(2) (IV), die durch die Kobalthydrid‐Komplexe (I) und (II) katalysiert wird, läßt sich durch Zugabe von molekularem Stickstoff beschleunigen.
ChemInform Abstract: OXIDATIVE DEOXIMATION
Authors: ARAUJO HUGO C. , FERREIRA GERALDO A. L. , MAHAJAN JASWANT R.
Published: March 2016

Verschiedene Ketoxime (Ia)‐(Ic) lassen sich oxidativ nach bislang nicht angewandten Verfahren [a), b), c)] in guten bis sehr guten Ausbeuten zu den entsprechenden Ketonen (II) desoximieren.
ChemInform Abstract: EFFECTS OF SUBSTITUENTS ON THE FORMATION OF ACETALS OF 4‐SUBSTITUTED 1,3‐INDANDIONES
Authors: SAKANE KAZUO , OTSUJI YOSHIO , IMOTO EIJI
Published: March 2016

Aus den Dionen (I) entstehen mit überschüssigem Glykol (II) in säurekatalysierter Reaktion (p‐Toluolsulfonsäure) je nach Reaktionsdauer die Produkte (III)‐(V), die sich einzeln beim Erhitzen in Benzol zu den beiden anderen umwandeln lassen.
ChemInform Abstract: UNGESAETTIGTE AETHER 36. MITT. SYNTHESE UND UNTERSUCHUNG HOEHERER ALPHA,BETA‐UNGESAETTIGTER ALKENALE UND ALKADIENALE
Authors: MAKIN S. M. , GABRIELYAN S. M. , CHEBOTAREV A. S. , VLADIMIRSKAYA E. K. , MORLYAN N. M.
Published: March 2016

Durch FeCl3 katalysierte Additionen der Acetale (I) an Äthylvinyläther (II) bei Obis 20°C liefern die Triäthoxyalkane (III); diese Triäthoxyverbindungen gehen beim Erhitzen mit (NH4)H2PO4 auf 150‐160°C in die Alkenale (IV) über.
ChemInform Abstract: THE REACTION OF ALPHA‐OLEFINS AND EPOXYALKANES WITH THE DIMETHYL SULFIDE‐SULFUR TRIOXIDE COMPLEX
Authors: NAGAYAMA MASUZO , OKUMURA OSAMU , YAGUCHI KATSUMI , MORI AKIRA
Published: March 2016

Die Olefine (I) setzen sich mit dem Dimethylsulfid‐SO3‐Komplex zu den Sulfonium‐sulfonaten (II) um, die sich durch Behandlung mit Alkali quantitativ in die Alkensulfonate (III) überführen lassen.
ChemInform Abstract: ASYMMETRIC SYNTHESIS OF AMIDOTHIOSULPHITES, SUBSTITUTION AT SULPHUR WITH RETENTION OF CONFORMATION
Authors: MIKOLAJCZYK M. , DRABOWICZ J.
Published: March 2016

Das Isothiocyanat (I!) reagiert ′mit den Diamiden (II) und den Thiolen (III) zu den optisch aktiven Amidothiosulfiten (IV) und den Thiocarbonsäureamiden (V).
ChemInform Abstract: REAKTION VON BICYCLO(4,2,2)DECA‐2,4,7,9‐TETRAEN MIT CARBENEN
Authors: SCHROEDER G. , THIO J. , OTH J. F. M.
Published: March 2016

Dilarom‐carben (II) addiert an Bicyclo(4,2,2)decatetraen (I) zu den im Gleichgewicht stehenden Addukten (IIIa) und (IVa) sowie dem Addukt (V).
ChemInform Abstract: HALOGENIERUNG VON TRIFLUORMETHYLBENZOLEN 1. MITT. PHOTOCHLORIERUNG VON BENZOTRIFLUORID
Authors: USHAKOV A. A. , MOTSAREV G. V. , ROZENBERG V. R. , KOLBASOV V. I. , BELOVA L. V. , CHUVAEVA I. N.
Published: March 2016

Die Chlorierung von Benzotrifluorid unter der Einwirkung von Hg‐Licht (oder auch in Gegenwart von Radikalinitiatoren wie Azodiisobutyronitril) mit einem C12 ‐Überschuß liefert das Hexachlorderivat (II).
ChemInform Abstract: 3‐METALLIERTE ENAMINE 3. MITT. METALLIERUNG VON 3‐ UND 1‐(N‐METHYLANILINO)‐PROPEN
Authors: AHLBRECHT H. , EICHLER J.
Published: March 2016

Allyl‐methylanilin (I) kann durch Butyllithium (II) in Gegenwart von Kalium‐t‐butanolat in Petroläther bei 0°C zu (III) metalliert werden, das mit Chlor‐trimethylsilan (IV) zu einem Gemisch der Produkte (V)‐(VII) reagiert.
ChemInform Abstract: POLYARYLANE ‐ SYNTHESE, EIGENSCHAFTEN, VERWENDUNG
Authors: BRZOZOWSKI ZBIGNIEW K. , KIELKIEWICZ JEDRZEJ , MILCZARSKA TERESA
Published: March 2016

Übersicht.
ChemInform Abstract: REACTION OF SULPHONYL AZIDES WITH UNSTRAINED OLEFINS
Authors: ABRAMOVITCH RUDOLPH A. , KNAUS GERALD N. , PAVLIN MARK , HOLCOMB WILLIAM D.
Published: March 2016

Bei längerem Erhitzen der entsprechenden Arylsulfonylazide mit überschüssigem Cyclohexen (I) in‐Benzol oder Cyclohexan entstehen Gemische der Imine (II) mit den Enaminen (III) (in denen, außer bei der Reaktion mit Ferrocensulfonylazid, die Imine überwiegen), die bei der Hydrolyse Sulfonarnide und Cyclohexanon geben.
ChemInform Abstract: LAYERED COMPOUNDS PART 18, SYNTHESIS OF A PARACYCLOPHANE CONTAINING THE 1,2,3,4,5‐HEXAPENTAENE GROUP AND THE STEREOCHEMISTRY OF ITS FORMATION
Authors: NEGI TAICHI , KANEDA TAKAHIRO , MIZUNO HIROSHI , TOYODA TOSHIHIRO , SAKATA YOSHITERU , MISUMI SOICHI
Published: March 2016

Das Diketon (IIIa) entsteht aus dem Diester (I) über die Bisgrignardverbindung (II).
ChemInform Abstract: CHEMISTRY OF ALPHA‐HALOALDEHYDE PART 6, REACTION OF 2‐CHLORO‐2‐METHYLPROPANAL WITH BENZOYLACETONITRILE IN THE PRESENCE OF POTASSIUM CARBONATE
Authors: TAKEDA AKIRA , TSUBOI SADAO , SAKAI TAKASHI
Published: March 2016

Der Aldehyd (I) setzt sich mit Benzoylacetonitril zu dem Dihydrofuran (II) oder dem Enol (IV) um, je nachdem, ob man die Komponenten zusammen in wäßriger Carbonatlösung reagieren läßt, oder ob vor dem Zusatz des Nitrils zunächst (I) in wäßriger Carbonatlösung eine Std. lang bei Raumtemperatur gerührt wird.
ChemInform Abstract: LADUNGSVERTEILUNG IN VERBRUECKTEN IONEN
Authors: GIESE B.
Published: March 2016

Im Zusammenhang mit Untersuchungen über die Reaktivität verbrückter Ionen werden die Norbornene (I) mit den elektrophilen Reagentien (II) zu den Addukten (III) und (IV) umgesetzt.
ChemInform Abstract: ACTION OF GRIGNARD REAGENTS AND ARYLLITHIUMS ON 6‐HYDROXY‐4‐METHOXY‐ AND 6‐HYDROXY‐4,7‐DIMETHOXY‐5‐ARYLACRYLOYL‐BENZO(B)FURANS
Authors: NOSSEIR M. H. , AZIZ GAMIL , DOSS N. L. , RISK A. S.
Published: March 2016

Die Cinnamoylbenzofurane (I) reagieren mit den aliphatischen bzw. aromatischen Grignardverbindungen (II) zu den Propionylbenzofuranen (IIIa) bzw. (IIIb).
ChemInform Abstract: DIMERISIERENDE CYCLISIERUNGEN VON 1,5‐DI‐TERT.‐BUTYL‐3‐BROM‐PENTA‐1,4‐DIIN ZUM THIENOCYCLOBUTEN‐SYSTEM SOWIE ZU 1,4‐DITHIACYCLOALKANEN MIT ANELLIERTEM CYCLOBUTANRING
Authors: HAUPTMANN H.
Published: March 2016

Bei der Behandlung mit Natriumsulfid erhält man aus den 3‐Brom‐1,4‐pentadiinen (I) unter Annahme der Zwischenstufen (II) und (III) die Thiophene (IV).
ChemInform Abstract: STUDIES ON ANTIANAPHYLACTIC AGENTS PART 3, A NOVEL CONVERSION REACTION OF 4‐OXO‐4H‐1‐BENZOPYRAN‐3‐CARBOXALDEHYDES TO 3‐HALOGENOCHROMONES
Authors: NOHARA A. , UKAWA K. , SANNO Y.
Published: March 2016

Die Aldehyde (I) reagieren mit NaOCl in Essigsäure zu den Chlorchromonen (II); neben (IIa) wird in geringer Menge die Verbindung (III) isoliert.
ChemInform Abstract: SYNTHESIS OF DITHIENO(2,3‐B/3′,2′‐E)‐8H‐THIOPYRAN‐8‐THIONE AND DITHIENO(2,3‐B/3′,2‐E)‐8H‐THIOPYRAN‐8‐ONE
Authors: GROL C. J.
Published: March 2016

Das Dioxolan (I) reagiert mit Bu‐Li und Schwefel zu den Thiopyronen (II) und (IV) (UV‐ und NMR‐Spektren) und dem Dioxolan (III).
ChemInform Abstract: PURINE‐6,8‐DIONES, A STUDY OF THEIR IONISATION AND THEIR METHYLATION REACTIONS
Authors: RAHAT MIRIAM , BERGMANN F. , TAMIR IIANA
Published: March 2016

Die (bis auf eins) methylsubstituierten Purindione werden in die drei Klassen (I)/(II), (III) und (I.V)/(V) eingeteilt, die sich in ihren physikalischen Eigenschaften unterscheiden.
ChemInform Abstract: SYNTHESIS OF THE 5‐THIA‐1,3,6‐TRIAZACYCL(3,2,3)AZINE AND 4‐THIA‐1,3,6‐TRIAZACYCL(3,2,3)AZINE SYSTEMS
Authors: CEDER O. , BEIJER B.
Published: March 2016

Kondensation des Diaminothiazols (I) mit dem Acrylat (II) liefert die isomeren Thiaz le (III) und (IV) (4: 1‐Gemisch).
ChemInform Abstract: TRIMETHYLSILYL ENOL ETHERS FROM BICYCLIC KETONES AND DIMETHYLAMINOTRIMETHYLSILANE
Authors: HELLBERG L. H. , JUAREZ A.
Published: March 2016

Die bicyclischen Ketone (II) reagieren mit Dimethylaminotrimethylsilan (III) nicht zu den erwarteten Enaminen (I), sondern zu den Enol‐silyläthern (IV).
ChemInform Abstract: NMR‐UNTERSUCHUNGEN AN SILYLPHOSPHINEN 2. MITT. SUBSTITUENTENEINFLUESSE IN SILYL‐ UND SILYLMETHYLPHOSPHINEN
Authors: FRITZ G. , SCHAEFER H.
Published: March 2016

Die NMR‐Spektren von 24 Silylphosphinen des Typs (I)‐(III) werden untersucht.