bluuebunny/crossref_metadata_2025 huggingface dataset:
Anti-Inflammatory Effects Of Calcitriol-Treated Mesenchymal Stem Cells On Experimental Ulcerative Colitis
Authors: Abdi Hossein , Ghaleh Hadi Esmaeili Gouvarchin , Kondori Bahman Jalali , Motlagh Bahman Mansori
Published: January 2022

Objective — Ulcerative colitis is an inflammatory bowel disease usually affecting the innermost lining of the colon and rectum. Both corticosteroids and anti-inflammatory drugs are administrated as medical treatment for UC. However, these drugs, in addition to chemical side effects, impose exorbitant costs on patients. Therefore, extensive studies are underway to find new treatment approaches. This study aims to determine the effect of calcitriol-treated mesenchymal stem cells in the UC treatment. Material and Methods — This experimental study was performed on 50 Wistar rats with inducing ulcerative colitis model by 4% acetic acid. MSCs were isolated from rat bone marrow and proliferated in an appropriate medium. Bone marrow-derived mesenchymal stem cells were injected intraperitoneally. Symptom severity of this disease was evaluated using the factors, such as stool consistency, fecal blood and histopathological study of colon tissue. Furthermore, the levels of myeloperoxidase, nitric oxide and inflammatory cytokines like IL1, IL6 and TNF-α were measured using ELISA technique. Results — The results showed that calcitriol-treated MSCs, significantly reduced the production of inflammatory cytokines including IL-1 (150.22±29.04)(P<0.01), IL-6 (681±56.20)(P<0.01), TNF-α (53.07±11.30)(P<0.01) and significantly decrease in level of NO (12.86±5.65)(P<0.01), MPO (0.175±0.024)(P<0.01) and the destruction of intestinal crypts compared to the control group (P<0.05). Conclusions — It seems that using calcitriol with MSCs has reduced the symptoms of UC in our experimental model. Due to their ease of isolation and expansion, MSCs can be used as an adjunctive therapy to improve the condition of patients with UC colitis.
Hemocompatibility And Cytotoxicity Of Small-Diameter Bioabsorbable Tissue-Engineered Vascular Grafts Depending On Anti-Thrombogenic And Antimicrobial Coating
Authors: Krivkina Eugenia O. , Velikanova Elena A. , Senokosova Eugenia A. , Khanova Maryam Yu. , Glushkova Tatyana V. , Antonova Larisa V. , Barbarash Leonid S.
Published: January 2022

Anti-thrombogenic and antimicrobial coatings of polymer grafts constitute a promising approach to preventing infection and thrombosis of vascular grafts. The objective was to study the hemocompatibility and cytotoxicity of PHBV/PCL grafts with iloprost and amphiphilic coating. Material and Methods — Polymer matrices were manufactured by electrospinning a mixture of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and poly(ε-caprolactone) (PCL) polymers. Several matrices were modified by complexation between polyvinylpyrrolidone (PVP) and cationic amphiphile and/or iloprost. The amphiphile was covalently cross-linked to the surface of other PHBV/PCL matrices. Unmodified PHBV/PCL matrices were used as the control group. Hemocompatibility and cytotoxicity of scaffolds before and after the modification were evaluated. Results — The hemocompatibility assessment revealed that hemolysis degree did not exceed normal values in all types of matrices. The PHBV/PCL/PVP matrices had increased platelet aggregation on the surface of the grafts. Subsequent addition of iloprost and amphiphile resulted in a sevenfold reduction of platelet aggregation. In PHBV/PCL/PVP matrices, the degree of platelet adhesion increased without changing the platelet deformation index values. Iloprost and amphiphilic coating of PHBV/PCL/PVP matrices diminished the number of adhered platelets and platelet deformation index by 1.5 times. The amphiphile, covalently cross-linked to PHBV/PCL matrices, caused a negative effect on the platelet adhesion, aggregation, and deformation index values. Evaluation of cytotoxicity of PHBV/PCL/PVP matrices, coated with iloprost and/or cationic amphiphile, demonstrated a slight decline in the rates of cell growth and proliferation after three days. Moreover, after three days, cell deaths and a sharp drop in the cell index values were noted in PHBV/PCL matrices with covalently cross-linked amphiphile. Conclusion — Iloprost and amphiphilic coating of PHBV/PCL grafts has increased their hemocompatibility. Also, there were no signs of cytotoxicity while using the complexation technique. However, covalently cross-linked amphiphile caused an increase in the cytotoxicity of matrices, which may have been indicative of the negative effect observed in this type of surface modification.
Antioxidant Activity Of Rat Liver With A Low Resistance To Hypoxia After Systemic Ischemia Reperfusion
Authors: Bayburina Gulnar A. , Nurgaleeva Elena A. , Samigullina Ajgul F. , Farshatova Ekaterina R. , Ganeev Timur I. , Agletdinov Eduard F. Agletdinov , Tarasova Tatyana V.
Published: January 2022

Objective — To assess the antioxidant activity of rat liver after systemic ischemia reperfusion (IRP). Material and Methods — The study was conducted on 70 male rats. For all animals of the treatment group (n=35) under ether anesthesia, we were stopping stopping systemic circulation for five minutes. After that, the animals were given an external cardiac massage and artificial lung ventilation. We did not perform circulatory arrest after ether anesthesia in animals of the control group (n=35). In all animals, we were measuring the levels of serum hormones (corticosterone, aldosterone), the content of glucocorticoid and mineralocorticoid receptors in liver homogenates, and the activity of enzymes of the antioxidant system (superoxide dismutase and catalase). We were making control measurements on days 1, 3, 5, 7, 14, 21, and 35 after the simulated IRP. Results — On day 1 after simulation of IRP development, the levels of cortisol and aldosterone in the serum of treatment group rats were significantly higher, by 14.3% and 33.5%, respectively, compared with the control group. In response to stress (IRP), we observed the highest concentration of cortisol in the blood of treatment group rats on day 3 (p=0.0002), which decreased afterwards. On day 1 after IRP, there was a reduction in the activity of superoxide dismutase and catalase in treatment group rats, by 50.3% and by 29%, respectively (p<0.0001). The lowest antioxidant activity in the rat liver after IRP was observed on days 3-7. Conclusion — Systemic IRP is associated with pronounced changes in the dynamics of corticosteroid receptors in the liver, which leads to a reduction in the activity of key antioxidant enzymes.
Stimulation Of Neutrophil Oxidative Burst By Calcium Phosphate Particles With Adsorbed Mucin
Authors: Mikhalchik Elena V. , Boychenko Olga P. , Moskalets Alexander P. , Morozova Olga V. , Klinov Dmitry V. , Basyreva Liliya Yu. , Gusev Sergey A. , Panasenko Oleg M. , Filatova Lyubov Yu. , Balabushevich Nadezhda G.
Published: January 2022

Objective — Mucin can promote formation of gallstones via precipitation with calcium phosphate. The proinflammatory effect of mucin-coated particles is still unclear, and our aim was to study the role of mucin sorption in activation of neutrophil respiratory burst. Material and Methods — Polydisperse calcium phosphate nanowires (CP) were prepared from hot gelatin solution and according to scanning electron microscopy (SEM) had the length 1-10 μm and thickness 50-450 nm. CP were incubated in mucin or human serum albumin (HSA) giving CP-Muc and CP-HSA. Their hemolytic activity towards human erythrocytes was assayed, and neutrophil lucigenin- and luminol- chemiluminescence (Luc-CL and Lum-CL) response to CP, CP-HSA and CP-Muc was measured. Cytokine RNA was detected in neutrophils by means of reverse transcription with subsequent real-time PCR. Cytokines (IL-1β, IL-6, IL-8, IL-10) were assessed in cell medium by ELISA. Results and Conclusion — Hemolytic activity of CP was 3.0±0.5%, mucin sorption (0.019 mg/mg) reduced it to 0.24±0.04% (p<0.05) as well as HSA. CP and CP-HSA stimulated neutrophil Lum-CL and Luc-Cl by 2-3 times vs. spontaneous values while for CP-Muc the effect was 10-fold and higher. No increased cytokine gene expression or cytokine secretion was detected after 1h incubation of neutrophils with samples. Obviously, sorption of mucin but not that of HSA stimulated generation of reactive oxygen and halogen species with no increase in cytokine production. Thus, the mucin-coated CP has the potential to contribute to gallstone-associated cholecystitis via oxidative damage of mucosa and epithelium.
Etiological role of opportunistic microflora
in the pathogenesis of implant-associated inflammation
after primary total knee replacement
Authors: Babushkina Irina V. , Bondarenko Alexander S. , Ulyanov Vladimir Yu. , Chibrikova Yulia A. , Adilov Ramin G. , Kupina Ekaterina S.
Published: January 2022

Objective: to investigate etiological role of opportunistic microflora in the pathogenesis of implant-associated inflammation in patients after primary knee replacement and antibiotic resistance of major infectious agent groups.
Material and Methods. We conducted the retrospective analysis of microbiological samples from 383 patients with postoperative implant-associated inflammation after the primary total knee arthroplasty.
Results. Gram-positive cocci (63.5%) are the leading agents of implant-associated inflammation. We also noted an increase in the etiological role of coagulase-positive staphylococci. Among the Gram-negative group, Enterobacteriaceae and non-fermenting bacteria were major agents. We revealed high resistance of Staphylococcus spp. to antibiotics of various groups, among which oxazolidinones and glycylcyclines were the most active. Gram-negative bacteria exhibited high resistance to cephalosporine and macrolides, whereas carbapenems and fluoroquinolones worked best.
Conclusion. Gram-negative Enterobacteriaceae, non-fermenters, and Gram-positive cocci are the most significant etiological factors in the pathogenesis of implant-associated inflammation in patients after primary total knee arthroplasty.
PENGARUH KEPEMIMPINAN, DISIPLIN DAN BUDAYA ORGANISASI TERHADAP KINERJA PEGAWAI
Authors: Wardaka Adhitya Irvan , Pramusinto Hengky
Published: January 2022

This study was aims to analyze the influence Leadership, Discipline, and Organization Cultur to Employee Performance both simultaneously or partially. The population of this study was 107 employees in the villages in Sukoharjo Sub-district Sukoharjo regency, Central Java. This research uses proportional random sampling as technique which is calculated using Slovin formula that produces 84 respondents. The data collection method was accomplished by doing also using questionnares, observation, interviews, and documentation. This research uses data analysis method with percentage descriptive analysis and regression analysis. The results showed that (1) there is a significant influence between leadership, discipline, and organization culture on employee performance in the villages in Sukoharjo Sub-district, (2) there is no significant influence between leadership on employee performance in the villages in Sukoharjo Sub-district, (3) there is a significant influence between discipline on employee performance in the villages in Sukoharjo Sub-district, (4) there is a significant influence between organization cultur on employee performance in the villages in Sukoharjo Sub-district.
KEEFEKTIFAN MODEL PERKULIAHAN DARING DALAM PERKULIAHAN EKONOMI MAKRO BERMUATAN PLURALISME
Authors: Meiriza Mica Siar
Published: January 2022

Semakin berkembangnya teknologi informasi dan komunikasi juga mempengaruhi model pembelajaran yang digunakan dalam dunia pendidikan. Bagaimana setiap orang dapat belajar dimana saja, kapan saja dan dengan siapa saja, tidak dibatasi jarak dan waktu. Penelitian ini bertujuan untuk mengembangkan model pembelajaran daring atau Online Learning Model (OLM) dengan memanfaatkan aplikasi sosial media berbasis internnet dan telepon seluler sebagai sarananya. Model pembelajaran daring ini sekaligus digunakan untuk meningkatkan keefektifan perkuliahan Ekonomi Makro bermuatan pluralisme. Subjek penelitian ini adalah Mahasiswa S1 Fakultas Ekonomi Universitas Negeri Medan yang mengambil mata kuliah Ekonomi Makro. Penelitian ini menggunakan metode campuran. Pengumpulan data dilakukan dengan menggunakan kuesioner dan tes. Hasil penelitian memperlihatkan bahwa: (1) OLM efektif digunakan dalam perkuliahan Ekonomi Makro bermuatan pluralisme; (2) model pembelajaran juga mampu meningkatkan penyerapan mahasiswa terhadap materi pembelajaran lebih dari 80% dibandingkan jika hanya memanfaatkan sistem konvensional yaitu tatap muka saja; (3) hasil kuesioner juga memperlihatkan bahwa mahasiswa merasa mendapatkan pengalaman baru belajar melalui OLM dan lebih menantang jika dibandingkan dengan belajar konvensional.
Sistem Pembayaran E-Money Di Pintu Masuk Pelabuhan Gilimanuk
Authors: Kartika Putra Kusuma , Indrayani Luh , Irwansyah M. Rudi
Published: January 2022

Tujuan dari penelitian ini yaitu untuk mengetahui persepsi masyarakat mengenai sistem pembayaran e-money di pintu masuk penyeberangan Pelabuhan Gilimanuk. Penelitian menggunakan penelitian dengan jenis penelitian deskriptif dengan pendekatan kualitatif untuk mendeskripsikan mengenai persepsi masyarakat mengenai sistem pembayaran e-money di pintu masuk penyeberangan Pelabuhan Gilimanuk. Populasi dalam penelitian ini yaitu pengguna e-money di pintu masuk penyeberangan Pelabuhan Gilimanuk dengan sampel yang digunakan sebanyak 405 responden yang dicari menggunakan sampling insidental. Metode pengumpulan data yang digunakan yaitu menggunakan kuesioner dan wawancara. Teknik analisis data yang digunakan dalam penelitian ini adalah analisis deskriptif. Hasil penelitian menunjukkan bahwa persepsi masyarakat dari indikator senang memperoleh skor 16.476 sehingga masuk ke dalam kategori kurang baik, indikator kecewa memperoleh skor 5.100 jadi dikategorikan tidak baik, indikator tingkah laku memperoleh skor 4.393 termasuk ke dalam kategori baik dan indikator ingatan memperoleh skor 7.217 termasuk ke dalam kategori baik.
Analisis Pedagogical Content Knowledge Guru Akuntansi
Authors: Mudrikah Saringatun , Astuti Dwi Puji , Pitaloka Lola Kurnia
Published: January 2022

Tujuan penelitian ini adalah menganalisis tingkat penguasaan Pedagogical Content Knowledge (PCK) guru akuntansi SMK di Kebumen dengan membandingkannya berdasarkan gender, sertifikasi profesi, jenjang pendidikan, latar belakang akademik, serta lama mengajar. Sampel penelitian seluruh guru Akuntansi SMK se Kabupaten Kebumen yang berjumlah 65 orang. Instrumen untuk pengumpulan data berupa kuesioner dengan teknik analisis data berupa analisis data deskriptif dan uji beda (one sample t-test) dengan menggunakan sofware SPSS v21. Hasil penelitian menunjukkan bahwa dilihat dari aspek yaitu: (1) gender, rata-rata penguasaan PCK bagi guru Akuntansi SMK di Kabupaten Kebumen baik, (2) sertifikasi guru yang diterima, rata-rata PCK guru Akuntansi SMK di Kabupaten Kebumen memiliki perbedaan, khususnya pada aspek pengetahuan konteks, (3) jenjang pendidikannya, rata-rata penguasaan PCK guru Akuntansi SMK di Kabupaten Kebumen baik, (4) latar belakang akademik, rata-rata penguasaan PCK guru Akuntansi SMK di Kabupaten Kebumen adalah sama kecuali pada aspek pengetahuan kurikulum, (5) pengalaman mengajarnya, rata-rata penguasaan PCK guru Akuntansi SMK di Kabupaten Kebumen adalah sama.
Markov Analysis of Water Discharge as an Indicator of Surface Water Security of the Bandung Basin
Authors: Wulandari S. , Sabar A. , Setiadi T. , Kurniawan B.
Published: January 2022

Water security is the fulfillment of access to adequate and sustainable water needs (quantity and quality) for the growth of human and ecosystem life and the ability to reduce risks associated with water. By knowing the water security of an area, efforts to conserve, utilize, control destructive force, develop information systems and participate in the community can be assessed to what extent and how the management has been carried out. The purpose of this research is to formulate the amount of water availability per capita (quantity) of surface water and to determine the quantity of the worst water quality at a critical time (the worst quantity) to be used as a reference in determining the amount of water resistance for development. The only observed water quality was the BOD (Biological Oxygen Demand) organic pollutant value in the dry year in the dry season using the Markov Chain Method. Water security in the Bandung Basin is currently classified as bad (rare) because the water availability index figures only indicate 174 m3 per capita per year (quantity). Meanwhile, data on the quality value of BOD (Biological Oxygen Demand) pollutants in dry years (R5) of 129 mg/l and very dry years (R10) of 112 mg/l which has also exceeded the class I quality standard of PP No. 22/2021 (> 2 mg/l) regarding water quality management and pollution control which is designated for raw water needs drinking water. Changing water use patterns and promoting effective implementation of integrated water resources management are essential strategies for increasing water security in Indonesia.
Examining the STEM-Science Achievement Test (SSAT) Using Rasch Dichotomous Measurement Model
Authors: Jamaludin J. , Lay Y. F. , Khoo C. H. , Leong A. S. Y.
Published: January 2022

The main purpose of this study is to develop a valid and reliable instrument to measure the STEM-Science achievement of primary school students in Malaysia. Six Year 4 Science topics (Scientific Skills, Life Processes of Human, Properties of Materials, Measurement, Solar System, Importance of Technologies in Life) and Six Year 5 Science topics (Rules and Regulation in Science Lab, Life Processes of Plants, Acids and alkali, Electricity, Earth and Space Science, Technology and Sustainable Life) have been included in the development of the STEM-Science Achievement Test (SSAT). 226 Year 4 and 226 Year 5 primary school students in Sabah responded to the developed instrument to test their STEM-Science knowledge. The Rasch dichotomous measurement model approach was used to evaluate the validity and reliability of the SSAT. The validity assessed the Point-Measure Correlation (PTMEA CORR), Principal Component Analysis of Residuals (PCAR), as well as Infit and Outfit Mean Squares (MNSQ). In terms of reliability, Cronbach’s alpha, item reliability, and item separation index were analysed. The analysis results revealed the presence of unidimensionality for both objective and subjective items. For objective items, the reported values for Cronbach’s Alpha are .81 and .83; item reliability are .95 and .95; item separation are 4.21 and 4.25 for Year 4 and Year 5 students, respectively. Standardised residual correlations for Year 4 and Year 5 subjective items also showed satisfactory values. The assessment using Rasch measurement model has proven that SSAT is a valid and reliable instrument to measure Malaysian primary students’ STEM-Science-related knowledge.
The Assessment of Water Compatibility of Adaptable Stick-Net Cage for Resilience Milkfish Cultivation in Tanjung Mas, Indonesia
Authors: Martuti N. K. T. , Sidiq W. A. B. N. , Melati I. S. , Mutiatari D. P.
Published: January 2022

Milkfish cultivation becomes the main livelihood of farmers in coastal areas. However, the land for milkfish cultivation is shrinking due to land use for settlements, industries, and sea-level rise. A Stick-net cage is an aquaculture solution in limited space for an inland fishpond. It can be placed in seashore areas while maintaining the quality of the aquatic environment and nutrient circulation. This study aims to analyze water compatibility in the stick-net cage areas for supporting sustainable aquaculture activities. An exploratory observational study was conducted in Tanjung Mas Village, Semarang, Central Java, Indonesia. Ten sampling areas were determined purposively by considering the point locations toward household wastewater and industrial outfalls. Based on these criteria, the ten stations used as sample areas were divided into industrial outfall areas (1st – 5th station) and areas close to the open sea (6th – 10th station). Physical parameters in the sampling areas, including temperature, water-current, turbidity, and clearness, met seawater standards for milkfish cultivation. Chemical indicators, such as NH4 and P in water, were very high, which may be caused by domestic and industrial waste contamination and increased organic fermentation activity on the seabed. However, the existing stick-net cages have exceeded the capacity of the coastal water areas. In general, the physicochemical parameters in the Tanjung Mas water area are suitable for milkfish cultivation. However, it is necessary to reduce the amount of pond density to give growth space for milkfish. In addition, wastewater management and treatment plants should be built up to reduce water contamination.
Tissue sensitivity to thyroid hormones may change over time
Authors: Radetti Giorgio , Rigon Franco , Salvatoni Alessandro , Campi Irene , De Filippis Tiziana , Cirello Valentina , Longhi Silvia , Guizzardi Fabiana , Bonomi Marco , Persani Luca
Published: January 2022

Introduction

Patients with congenital hypothyroidism (CH) may transiently show a certain degree of pituitary resistance to levothyroxine (LT4) which, however, normalizes subsequently. However, in some individuals, thyroid-stimulating hormone (TSH) fails to normalize despite adequate LT4 treatment.

Methods

Nine patients with CH followed in three Academic Centre who developed over time resistance to thyroid hormones underwent extensive biochemical and genetic analyses. These latter were performed by Sanger sequence or targeted next-generation sequencing technique including a panel of candidate genes involved in thyroid hormone actions and congenital hypothyroidism (CH): THRA, THRB, DIO1, DIO2, SLC16A2, SECISBP2, DUOX2, DUOXA2, FOXE1, GLIS3, IYD, JAG1, NKX2-1, NKX2-
5, PAX8, SLC26A4, SLC5A5, TG, TPO, TSHR.

Results

All patients displayed a normal sensitivity to thyroid hormone (TH) in the first years of life but developed variable degrees of resistance to LT4 treatment at later stages. In all cases, TSH normalized only in the presence of high free thyroxine levels. Tri-iodothyronine suppression test followed by thyrotrophin-releasing hormone stimulation was performed in two cases and was compatible with central resistance to THs. This biochemical feature was present independently on the cause of CH, being observed either in patients with an ectopic (n = 2) or eutopic gland (n = 3) or in case of athyreosis (n = 1). None of the patients had genetic variants in genes involved in the regulation of TH actions, while in two cases, we found two double heterozygous missense variants in TSHR and GLIS3 or in DUOX2 and SLC26A4 genes, respectively.

Conclusions

We report CH patients who showed an acquired and unexplainable pituitary refractoriness to TH action.
Selfie
Authors: Souza Joana Dourado França de , Couto Edvaldo Souza
Published: January 2022

O artigo apresenta resultados de uma pesquisa e tem como objetivo analisar publicações de selfies de um grupo de jovens no Instagram Stories. O principal argumento é de que esses jovens se valem de performances apropriadas através de pedagogias circulantes para espetacularizar a si nesta rede social. A fundamentação teórica considerou estudos nos campos das pedagogias culturais e da cibercultura aplicada à educação, notoriamente, os conceitos de visibilidade, performance e espetacularização do eu, atrelados às redes sociais digitais e em torno da denominada era da mobilidade, na qual as tecnologias móveis possibilitam a circulação de autorretratos digitais. O método utilizado foi o da pesquisa qualitativa, descritiva e analítica de cunho netnográfico. O artigo conclui que os jovens estudados espetacularizam suas vidas por meio de selfies para manutenção de visibilidade no Instagram Stories e, por conseguinte, evidenciam pedagogias e modos de ser que circulam nesta funcionalidade.
A boa vida e os seus componentes
Authors: Wagner Thaiani Rafaela
Published: January 2022

A eudaimonia é descrita por Aristóteles como um bem-viver (eu zen) constituído pelas atividades virtuosas das nossas potencialidades como animais que possuem razão e que seguem a razão. Somos, portanto, animais e racionais, e uma vida desse tipo precisa levar em conta esses dois aspectos da nossa natureza. Ao defendermos uma concepção aristotélica de boa vida, que leva em consideração tanto a racionalidade enquanto traço característico dos seres humanos como também a sua incontestável natureza animal, precisamos pensar na relação dessa boa vida com a tykhe. É possível acomodar satisfatoriamente a fortuna em uma vida que é dita como autossuficiente e instruída pel razão, mas que sofre as influências do mundo e da natureza? No presente texto, pretendo expor como Aristóteles buscou resolver esse aparente problema ao tentar compatibilizar o bem-viver com os acontecimentos do mundo que não dependem de nós para se realizarem.
Apresentação
Authors: Costa Claiton Silva da , Silva Pamela Ferreira da
Published: January 2022

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The Habsburg Mediterranean 1500–1800
Authors: McEwan Dorothea
Published: January 2022

This volume presents the Mediterranean as a crucial part of the social and cultural fabric of the early modern Habsburg world. The sea was a stage on which Habsburg history was made and unmade. The Habsburg Mediterranean was a space where constant changes and exchanges took place, touching hierarchies, power-relationships, commerce and the everyday actions of people. The cases in point focus on the significance of the Mediterranean as a site of transporting ideas, people, plants, animals and objects. These flows drew the Iberian and Central European branches of the Habsburg dynasty into overlapping, mutually interactive and at times competing relations.
The amino acids, bacterial communities, and their correlations in Wuliangye-flavour liquor production
Authors: Wang Q. , Liu K.Y. , Liu L.L. , Zheng J. , He C.R. , Jiang B.
Published: January 2022

With the enhancement of people’s awareness of drinking health, the health factors in Wuliangye-flavour liquor is worth our attention. Bacterial communities in 4 layers of Zaopei from the same fermentation pit and amino acids as major health factors in 4 liquors directly related Zaopeis were investigated by Illumina MiSeq sequencing and liquid chromatography mass spectrometry, respectively. Results indicated that 18 amino acids were detected and 8 dominant bacteria (genus level) were observed. Meanwhile, total amino acids, 11 amino acids (Glu, Asp, Val, etc), bacterial diversity, and the percentages of Lactobacillus and Pseudomonas increased with the increase of Zaopei’s depth; 5 amino acids (Pro, Ser, Phe, etc) and the percentages of Pediococcus and Bacteroides first increased and then decreased with the increase of Zaopei’s depth. Moreover, 11 amino acids were significantly (P < 0.01) and strongly (|ρ| > 0.8) positively correlated with Lactobacillus and Pseudomonas numbers.
Prehistoric Farming Settlements in Western Anatolia
Authors: Maltas Tom , Şahoğlu Vasif , Erkanal† Hayat , Tuncel Rıza
Published: January 2022

Recovery of archaeobotanical assemblages from Late Chalcolithic Bakla Tepe and Liman Tepe in western Anatolia has provided the opportunity for in-depth analysis of agricultural strategies and the organisation of farming-related activity at the two sites. We find that Late Chalcolithic farmers utilised five major crop taxa, potentially including two mixed crops. The two sites also provide the first evidence for Spanish vetchling and winged vetchling cultivation in prehistoric Anatolia and the earliest evidence for this practice to date anywhere. We suggest that the settlements were organised into small, co-residential households that processed and stored their own crops, but we also propose that potentially communal extra-household storage and high levels of social monitoring may attest to supra-household cooperation. The later agricultural history of the vetchling species and the prevalence of extra-household storage at sites in coastal western Anatolia and the eastern Aegean islands add to evidence for a cultural koine between these regions in the fourth and third millennia bc. We also suggest that the large size of extra-household storage structures and the narrow range of crops cultivated at some Late Chalcolithic sites are consistent with the emergence of more extensive farming systems than those of earlier periods. Evidence for the use of extensive agricultural production to amass arable wealth by the citadel elites of later Early Bronze Age western Anatolia suggests that the agro-ecological foundations for emergent wealth inequality within the region were laid during the Late Chalcolithic. Testing this hypothesis through direct evidence for the nature of Late Chalcolithic farming systems is a key aim of ongoing research.
Processo de trabalho na vigilância em saúde no Brasil: uma scoping review
Authors: Silva Claudia Maria Scheffel Corrêa da , Junges José Roque , Barbiani Rosangela , Schaefer Rafaela , Nora Carlise Rigon Dalla
Published: January 2022

Resumo Introdução A descentralização da vigilância em saúde demandou dos municípios uma reorganização dos processos de trabalho. Ao passo que aproximou o serviço do território, também suscitou desafios em formular propostas de intervenção sobre problemas de saúde. Objetivo Analisar o processo de trabalho dos profissionais que executam ações de vigilância em saúde no Brasil. Método Estudo de revisão da literatura de tipo scoping review. A estratégia de busca incluiu a consulta em bases de dados, Google Scholar e listas de referências, para artigos publicados entre 2000 e 2016. As buscas foram realizadas em abril de 2017 por dois pesquisadores, separadamente. A amostra compõe-se de 38 estudos. Resultados Resultaram cinco categorias: descentralização das ações de vigilância; vigilância em saúde e o trabalho em rede; processos educativos; análise territorial, e participação social. O processo descentralizado aproximou a vigilância do território e da comunidade, favorecendo a sua capacidade antecipatória, o trabalho intersetorial e a atuação ajustada aos problemas. Contudo, a descentralização ainda é um desafio na construção da vigilância como um trabalho em rede que tenha, como ponto de partida, a atenção básica, através de uma análise territorial. A resposta ao desafio exige processos de educação permanente e o engajamento participativo da comunidade e do controle social. Conclusão A descentralização exige ações conjuntas dos trabalhadores da vigilância e da atenção, tendo como base o território e as ações de cunho intersetorial e com participação social.
Curso em saúde mental no contexto da Covid-19 com povos indígenas por meio de ensino remoto
Authors: El Kadri Michele Rocha , Melo Bernardo Dolabella , Souza e Souza Michele , Noal Debora da Silva , Serpeloni Fernanda , Pereira Alessandra dos Santos
Published: January 2022

Resumo O enfrentamento à Covid-19 suscitou a necessidade da formação em Saúde Mental para profissionais da saúde, educação, proteção social e lideranças comunitárias que atuam junto aos povos indígenas. Em seus cotidianos, essas comunidades já convivem com questões que impactam a saúde mental e a espiritual, mas o sofrimento psíquico ficou ainda mais evidenciado no contexto pandêmico. O curso ‘Bem viver: Saúde Mental Indígena’, voltado para mitigar o impacto psicossocial da Covid-19 nas populações indígenas da Amazônia brasileira, exigiu estratégias inovadoras ante o desafio de ensino remoto nesse contexto de conectividade limitada e isolamento territorial. Os desenhos pedagógico e operacional do curso priorizaram o diálogo intercultural na elaboração dos conteúdos com uso de diversas ferramentas de ensino para superar barreiras de conectividade e de entendimento da língua portuguesa no formato escrito. Apesar do desafio da produção coletiva e intercultural, dada a diversidade étnica, o curso foi um espaço de produção e trocas entre profissionais de diferentes áreas e lideranças comunitárias, sempre buscando um olhar ampliado sobre as práticas de cuidado, apoio psicossocial e valorizando as formas de atenção à saúde utilizadas pelas comunidades.
Seguro Garantia em Infraestrutura no Brasil: Perspectivas de Custos de Transação e Teoria da Agência
Authors: Marques Tulio Henrique Moreira , Ogasavara Mario Henrique , Turolla Frederico Araujo
Published: January 2022

ABSTRACT Context: infrastructure projects assume the use of intensive capital and the participation of several actors, where the institutional environment influences their respective contractual arrangements. A financial instrument for project governance is surety bond (SB), whose purpose is to ensure compliance with the contracted object. However, research involving SB in the context of emerging countries such as Brazil is still incipient. Objective: this study aims to understand the use of SB in Brazil and proposes a conceptual model for analyzing transactions. It contributes to the literature by investigating the relationship between the actors and transactions involved in SB using the transaction costs theory and agency theory perspectives. Methods: this study adopts a qualitative methodology using primary data collected with 10 in-depth semi-structured interviews with market professionals with substantial experience in SB. In addition, it uses secondary data based on debate and a specific lecture on the topic involving the reality and the use of SB. Results: the findings indicate that the agency problem and the high transaction costs in Brazil prevent the development of this risk coverage market, giving rise to targeted public policies. Conclusion: the proposed conceptual model reflects the various specific transactions in the use of SB, the underlying phenomena and the validation of propositions related to market failures, and the institutional environment’s influence.
Os Limites Educacionais do Capital
Authors: Meletti Silvia Márcia Ferreira , Cabral Vinícius Neves de
Published: January 2022

RESUMO A partir da perspectiva do Materialismo Histórico, nosso objetivo neste artigo é construir uma crítica do que denominamos três dimensões básicas dos limites educacionais engendrados pela ordem sociometabólica do Capital, articulando a discussão desses limites ao potencial transformador e revolucionário da Educação. Partimos da concepção de que a contradição fundante da educação no Capital é apresentar-se como sistema de reprodução do quadro de valores e práticas do sistema ao mesmo tempo em que se constitui como via de contestação dessa mesma estrutura ideológica. Indicamos, em conclusão, que os limites da educação devem ser concebidos como parte do complexo quadro ideológico de referência do capital, e não apenas como elementos isolados.
Nietzsche e a relação entre arte, ciência e filosofia dos escritos de juventude até Humano, demasiado humano
Authors: Costa Abraão Lincoln Ferreira
Published: January 2022

Resumo: O artigo analisa o desenvolvimento da relação existente entre arte, ciência e filosofia no pensamento do jovem Nietzsche. Para tanto, recorre-se especialmente à consulta dosFragmentos Póstumosentre os anos de 1872 a 1875, possibilitando destacar os seguintes pontos: primeiro, a descoberta da filosofia pré-platônica como exemplo de conciliação das forças artística e científica e, segundo, a contribuição desses escritos para observância emHumano, demasiado humano(1878) da tipologia do “médico da cultura”, cuja função, similar a dos filósofos jônicos, será a de restaurar no mundo moderno a harmonia das mesmas pulsões, garantindo a manutenção de uma cultura elevada.
Desempenho em leitura, ordenação temporal, motivação e queixas escolares: estudo preliminar
Authors: Souza Cintia Alves de , Escarce Andrezza Gonzalez , Lemos Stela Maris Aguiar
Published: January 2022

RESUMO Objetivo verificar a associação entre o desempenho em leitura de crianças e adolescentes e a presença de queixas escolares, habilidade auditiva de ordenação temporal e motivação escolar. Métodos estudo observacional analítico transversal, com amostra de conveniência composta por 36 participantes. Os instrumentos de coleta foram questionário de caracterização, Critério de Classificação Econômica do Brasil, avaliação auditiva, testes de Memória para Sons Verbais, Não Verbais em Sequência, Padrão de Frequência e de Duração, Desempenho Escolar, as Provas de Avaliação dos Processos de Leitura e a Escala para Avaliação da Motivação Escolar Infantojuvenil. A variável resposta deste estudo foi “processos de leitura”. Os testes Qui-quadrado de Pearson e Exato de Fisher foram utilizados para as análises de associação. Resultados as análises de associação revelaram que a maioria dos participantes com alteração nas tarefas de leitura apresentou, também, adequação da ordenação temporal simples e inadequação da ordenação temporal complexa. Não houve associação com significância estatística entre o desempenho em leitura e a presença de queixas escolares, habilidade auditiva de ordenação temporal e motivação escolar. Contudo, observou-se que a maioria dos participantes com alteração na leitura apresentou queixa de dificuldades escolares, baixo desempenho acadêmico e motivação escolar média. Conclusão embora não tenha indicado significância estatística na maioria das associações realizadas, o presente estudo evidenciou que há relação entre o desempenho em leitura de crianças e adolescentes e a presença de queixas escolares, habilidade auditiva de ordenação temporal e motivação escolar.
Influence of the Poisson effect on the stress dependence of the elastic moduli of soil
Authors: Constandinou S. , Hanley K. J.
Published: January 2022

Effective medium theory and discrete-element method (DEM) simulations of smooth spheres both fail to correctly capture the small-strain stiffness of soil. The inability of the latter to capture small-strain stiffness can be overcome by adopting a rough-surface contact model, which includes the effect of asperity deformation. Hertzian spheres are commonly used in DEM which neglect the Poisson effect – that is, the lateral extension of a sphere orthogonal to an applied load. The hypothesis investigated in this paper is that this omission contributes to the inability of smooth-sphere DEM simulations to correctly capture the stress dependence of the elastic moduli of soil. This hypothesis was investigated using the finite-element method. At low-to-moderate confining stresses, the Poisson effect has little influence on the response. The Poisson effect becomes significant only at confining stresses on the order of 100 MPa, using parameters appropriate for a silica sand: stresses at which massive particle crushing would be expected. At lower stresses, rough-surface contact models remain the most justifiable way to match the stress–stiffness response measured in laboratory testing using DEM simulations.
Formación inicial de maestros de inglés en Colombia: Giros y desplazamientos
Authors: Méndez-Rivera Pilar , Guerrero-Nieto Carmen
Published: January 2022

Introducción: La formación inicial docente de maestros de inglés como categoría de análisis comporta una historicidad, que posibilita identificar formas particulares de ver y pensar al maestro de inglés en formación y al inglés como objeto de enseñanza. Objetivo: Explorar las tendencias imperantes en las normas producidas para regular la formación inicial de maestros de inglés y las relaciones de poder-conocimiento que se instalan en los currículos y discursos de formación docente. Metodología: Se utilizaron algunos procedimientos de arqueología foucaultiana para organizar temáticamente algunos discursos dominantes e identificar giros y desplazamientos en la historia de la formación de profesores de Inglés en Colombia entre 1990 y 2020. Resultados y Conclusiones: Los resultados permiten identificar giros y desplazamientos en las formas de pensar la formación inicial de maestros de inglés. Se produjo entonces un esquema de especificación que marcó dos trayectos equidistantes: Uno ligado al ideal de la formación profesional, la pedagogía y la investigación y otro, marcado por mecanismos de control y certificación de competencias.
El ABPrj como estrategia pedagógica aplicada en un curso de Programación Orientada a Objetos
Authors: Lasso-Cardona Luis
Published: January 2022

Objetivo: Evaluar el grado de percepción que tuvieron los alumnos con respecto al uso de la metodología ABPrj como herramienta usada en la asignatura de Introducción a la Programación Orientada a Objetos, dictada en segundo semestre en las sedes de Buga y Tuluá de la Universidad del Valle  Método: La investigación se realizó bajo un enfoque descriptivo-cuantitativo. El enfoque cuantitativo permitió medir los datos recolectados al aplicar la encuesta diseñada. El estudio se realizó en cinco fases: 1) Recolección de información, 2) Construcción del marco teórico, 3) Diseño y aplicación de la encuesta, 4) Análisis de datos recolectados, y 5) Conclusiones. Resultados: Se obtuvo una calificación promedio de 4.5 pts. equivalente al 90% de aprobación. Se logró establecer que existió una correlación entre la edad y el promedio de la evaluación, alcanzando su mayor diferencia en los estudiantes de Tecnología con un 16.61% Discusión y Conclusiones: Las pruebas estadísticas confirmaron la hipótesis del investigador, en cuanto a que no existieron diferencias muy marcadas en los estudiantes de Tecnología e Ingeniería respecto a la evaluación de la estrategia implementada
Comparison of the clinical effect of the adhesive strategies of universal adhesives in the treatment of non-carious cervical lesions. Systematic review and meta-analysis
Authors:   Escuela de Odontología, Universidad Peruana Los Andes, Lima, Perú, Lamas-Lara César , Arbildo-Vega Heber ,   Escuela de Estomatología, Universidad Señor de Sipán. Chiclayo, Perú.,   Escuela de Odontología, Universidad Particular de Chiclayo. Chiclayo, Perú.,   Centro de Salud Odontológico San Mateo. Trujillo, Perú., Cruzado-Oliva Fredy ,   Escuela de Odontología, Universidad Particular de Chiclayo. Chiclayo, Perú., Rosas-Prado Carmen ,   Escuela de Estomatología, Universidad Señor de Sipán. Chiclayo, Perú., Gómez-Fuertes Alberto ,   Escuela de Estomatología, Universidad Señor de Sipán. Chiclayo, Perú., Vásquez-Rodrigo Hernán ,   Facultad de Odontología, Universidad San Martín de Porres. Lima, Perú.
Published: January 2022

|Objective: To compare, through a systematic review and a meta-analysis, the clinical effect of the adhesive strategies of universal adhesives (UA) in the treatment of non-carious cervical lesions (NCCLs). Material and Method: A search of the literature was carried out up to January 2018, in the biomedical databases: Pubmed, Embase, Scielo, Science Direct, SIGLE, LILACS, BBO, Google Scholar and the Central Register of Cochrane Clinical Trials. The selection criteria of the studies were as: randomized clinical trials, with a maximum age of 5 years and which report the clinical effects (marginal adaptation, discoloration or marginal staining, presence of secondary caries, postoperative sensitivity, retention and fractures) of the UA in the treatment of NCCLs. The risk of study bias was analyzed through the Cochrane Handbook of systematic reviews of interventions. Results: The search strategy resulted in eight articles that reported no difference in marginal adaptation, discoloration or marginal staining, presence of secondary caries and postoperative sensitivity among the adhesive strategies of the UA; however they reported a difference between the retention and the presence of fractures, with the conventional adhesive strategy resulting in a better clinical effect. Conclusion: The reviewed literature suggests that the conventional adhesive strategy of UAs results in greater retention and absence of fractures in the treatment of NCCLs.
PENGARUH PERLAKUAN PANAS TERHADAP PERILAKU TARIK DAN STRUKTUR MIKRO BAJA TAHAN KARAT AISI 304 PADA DAERAH SENSITISASI 600 – 700 °C
Authors: Sungkono Sungkono , Ismarwanti Sri
Published: January 2022

PERILAKU TARIK DAN STRUKTUR MIKRO BAJA TAHAN KARAT AISI 304 PASCA PERLAKUAN PANAS PADA DAERAH SENSITISASI 600 – 700 °C. Baja tahan karat AISI 304 digunakan sebagai komponen struktur reaktor daya tipe LWR. Dalam pembuatan komponen struktur, kualitas sambungan lasan SS 304 ditentukan oleh proses pendinginan dari temperatur austenit ke sensitisasi. Tujuan penelitian adalah mengetahui karakter kekuatan tarik, kekerasan dan struktur mikro SS 304 pada daerah sensitisasi 600-700 °C. Metoda penelitian yang digunakan adalah pengujian komposisi kimia, tarik, kekerasan, dan struktur mikro yang mengacu pada ASTM. Hasil penelitian menunjukkan bahwa kekuatan tarik SS 304 pasca perlakuan sensitisasi pada (600 °C, 30- 60 menit) dan (700 °C, 30-90 menit) relatif sama dan lebih rendah dibandingkan tanpa perlakuan panas, sedangkan pada (600 °C, 90 menit) relatif sama dengan sampel tanpa perlakuan panas. Struktur mikro SS 304 terdiri atas fasa ferit-d dan austenit serta presipitat khrom karbida. Kuantitas presipitat di batas butir menurun dengan bertambahnya temperatur dan waktu penahanan. Kekerasan pasca perlakuan sensitisasi pada 600 - 700°C relatif sama di base metal, dekat patahan dan daerah patahan. Ketangguhan retak terbaik diperoleh pada sampel SS 304 dengan perlakuan (700 °C, 90 menit).Kata kunci: baja tahan karat, sensitisasi, kekuatan tarik, kekerasan, struktur mikro, presipitat.
Economía circular y protección de la salud
Authors: Boto Álvarez Alejandra
Published: January 2022

This paper focuses, within the so-called legal regime of the circular economy, at the instruments connecting with health protection. After contextualizing both realities (I), the research explores their concomitances, which pose relevant conceptual and methodological challenges (II). Afterwards, a review of the circular economy in Spain regulation is undertaken, in order to consider its impact on health, in terms of transversal opportunities and risks (III). Finally, the health sector as a concrete actor of the circular economy is considered, paying attention to the situation generated by the pandemic (IV).
Nanotrap® KingFisher™ Concentration/Extraction & MagMAX KingFisher™ Extraction v1
Authors: Sablon III Orlando , VanTassell Jamie , Raymond Julia , K Wolfe Marlene , Liu Pengbo , Moe Christine
Published: January 2022

These protocols have been adapted from Ceres "Nanotrap® Wastewater Protocol using MagMAX Kits" (APP-030, Revision 0, Nov 2021). This protocol uses Nanotrap® Magnetic Virus Particles and Nanotrap® Enhancement Reagent 1 (ER1) to capture and concentrate viruses in wastewater samples. It is optimized for viral capture from 10 mL samples of wastewater and is compatible with three nucleic acid extraction kits from ThermoFisher. This protocol has been used and adapted for SARS-CoV-2 viral capture at Emory University for wastewater surveillance of COVID-19.
diDO-IPTL protocol v1
Authors: Waldbauer Jacob , Zhang Lichun
Published: January 2022

Isobaric peptide termini labeling (IPTL) is a quantification method which permits relative quantification using quantification points distributed throughout the whole tandem mass spectrometry (MS/MS) spectrum. It is based on the complementary derivatization of peptide termini with different isotopes resulting in isobaric peptides.
Как оживает история. Технические решения музея-макета «Петровская Акватория»
Authors:   Музей-макет «Петровская Акватория», Масленникова О.А.
Published: January 2022

В современном мире «клиповое» мышление становится присуще все большему количеству людей. Музеи, одна из задач которых заключается в воспитании интереса к культуре и истории, сегодня ищут разные подходы к своим посетителям. Какие технические решения позволяют заинтересовать изучением прошлого, пробуждая стремление к пополнению полученных знаний, рассматривается в данной статье на примере инженерных разработок музея-макета «Петровская Акватория».