bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of pollutant emissions from a railbus in real operating conditions during transport work
Authors: Rymaniak Łukasz , Wisniewski Sławomir , Woźniak Krystian , Frankowski Maciej
Published: July 2023

The article discusses issues related to the assessment of pollutant emissions from a railbus during transport work. The test object was a rail vehicle equipped with two diesel engines with a total power of 780 kW, Stage IIIB homologated. Measurements were carried out on the route Poznań - Wągrowiec in two directions. During the tests, the vehicle performed a transport service, where the number of passengers was counted. For the completed cycles, the average number of people was 82 and 18. On the basis of the obtained data, the vehicle operating conditions and emission indicators were analyzed, which were related to the number of passengers. A dimensionless toxicity index was also determined.
The Impact of Tempeh Milk and Soymilk on Adolescent Hemoglobin Level
Authors: Sari Ayu Pravita , Yuniarti Putri , Krisnasary Arie
Published: July 2023

Among Indonesia, there is a 42% of anemia in adolescent girls. Study becomes challenging for those with anemia because blood may not bind oxygen from lungs to the rest of the body effectively. Consume soy and tempeh milk can be alternative treatment for anemia patients. In this study, young girls at SMP Negeri 2 Bengkulu City were tested to see how well tempeh milk and soy milk increased hemoglobin level. This study involved 36 young girls, aged 12 to 14, subjected to two-group pretest and posttest quasi-experimental design. The sample was taken by purposive sampling technique followed inclusion criteria namely, do not have infectious diseases and do not have blood disorders. The first treatment was given 200 mL of tempeh milk and the second treatment was given 200 mL of soy milk for 14 days. The average hemoglobin level of adolescent girls before intervention with tempeh milk is 12.8 g/dL and after the intervention was increased to 14.2 g/dL. The average hemoglobin level of adolescent girls before intervention with soy milk was 12.7 g/dL and after the intervention was increased to 13.7 g/dL. Tempeh milk and soy milk had the same effectiveness in increasing hemoglobin levels of adolescent girls at SMP Negeri 2 Bengkulu City.
BODY MASS INDEX, BODY DISSATISFACTION, AND SOCIAL ENVIRONMENT CORRELATED TO UNHEALTHY DIETARY BEHAVIORS IN ADOLESCENT GIRLS
Authors: Amalia Diva , Tri Rejeki Andayani  , Sapja Anantanyu
Published: July 2023

The physical changes in adolescent girls raise concerns about body weight and shape, thus encouraging adolescents to go on a weight-control diet is necessary. This study aimed to analyze the relationship between body mass index, body dissatisfaction, and social environment on unhealthy diet behaviors of adolescent girls. This study used a cross-sectional design with 80 adolescent girls aged 16-18 years recruited as the study participants by purposive sampling. Data were obtained from height and weight measurements, the Body Shape Questionnaire (BSQ-34), the social environment questionnaire, and the diet behavior questionnaire. Analysis of the relationship between variables using Somers'd test. The results of this study indicated that most of the respondents were 16 years old (53.8%), had good nutritional status (58.8%), and had daily pocket money of 15,000-20,000 IDR (51.3%). There was a correlation between body mass index (p < 0.001, d = 0.545), body dissatisfaction (p < 0.001, d = 0.624), and social environment (p < 0.001, d = 0.697) on unhealthy diet behavior in adolescent girls. Wrong perceptions of body weight status will increase dissatisfaction with the body and quickly get pressure from the social environment, thus encouraging the desire to go on a diet to control weight which tends to be unhealthy. Therefore, preventing unhealthy diet behavior in adolescent girls can be done by providing nutritional education about calculating body mass index values and efforts to control healthy weight.
Differences in the Breastfeeding Babies Anthropometic Status Based on the Practice of Mothers Consuming Torbangun (Coleus Amboinicus Lour) Leaves in Toba Regency
Authors: Silalahi Serlina , Probandari Ari , Mulyani Sri
Published: July 2023

Torbangun leaves (coleus ambonicus lour) are a typical food in Toba Regency that can increase the secretion rate and volume of breast milk production. It is assumed that the existence of lactagogum can increase the achievement of breast milk coverage, but in contrast to the achievement of exclusive breastfeeding, it is still below the national target of 24.3% in Toba Regency.The purpose of this study was to analyze differences in the anthropometric status of breastfeeding babies based on the practice of mothers consuming and building in Toba Regency. The observational research method with a prospective cohort design with an observation time of two months with three anthropometric status measurements was carried out in May-July 2022. The research samples amounted to 226 people, divided into 2 groups, namely babies from mothers who consumed torbangun leaves and babies from mothers who did not consume. Determination of research samples with multistage random, data analysis using independent t-tests and mann-whitney tests. The results of the study did not have a difference in anthropometric status based on the z-score index WAZ (p=0.251), HAZ(p=0.305),WHZ(p=0.373) between babies from mothers who consumed torbangun leaves and babies from mothers who did not consume. Overall, the anthropometric status of the study subjects was between Z scores ≥-2 SD and ≤ 2 SD. It was concluded that there was no significant difference in anthropometric status based on the z-scores of WAZ, HAZ and WHZ.
Closed Form Solutions to a Class of Pursuit Problems Using Geometric Analogies
Authors: Lovett Michael , Unterkofler Ana
Published: July 2023

This article studies a class of pursuit problems admitting both a simple geometric solution as well as a more general analytic treatment. The results are specialized to demonstrate solutions to certain elementary problems typically posed to high schoolers, although a full analytic treatment, requiring some more comfort with geometry and calculus, is typically avoided at that stage.
Active Labyrinthine Transmissive Ultrasonic Metamaterial
Authors: Choi Christabel , BANSAL SHUBHI , Hardwick James , Münzenrieder Niko , Tiwari Manish , Subramanian Sriram
Published: July 2023

It is highly desirable to engineer multiple operational states in a single metamaterial device. Here, we present a powerful approach to transform a conventionally passive metamaterial into an actively reconfigurable metamaterial, using dynamic standalone unit cells, called dynamic meta-bricks. These 3D-printed meta-bricks comprise an actuatable internal magnetorheological elastomeric flap, designed for active ultrasonic (40 kHz) transmission and modulation. Computational assembly of dynamic and static meta-bricks generates controllable hybrid metamaterial stacks, within a composite metasurface. We demonstrate for the first time, dynamic acoustic levitation with a transmissive metasurface, showcasing that partial peripherally localised actuation, can enable full array operational dynamicity. Without re-assembly, actuating the dynamic meta-bricks shifts an acoustically trapped bead in mid-air in real-time, while maintaining acoustic levitation. This work uncovers the potential for strategic synergy between active and passive reconfigurability, opening novel possibilities to develop versatile, integrated, multifunctional metamaterials with enhanced degrees of freedom in design and control.
Prediction of Mechanical Properties of FDM Printed PLA Parts using Response Surface Methodology.
Authors: Thakur Ayushi , Vates Umesh Kumar , Mishra Sanjay
Published: July 2023

Purpose: In the present work significant process parameters (nozzle temperature, layer thickness, and printing speed) are optimized for enhancing the mechanical properties of fused deposited PLA specimens. The selected parameters in this study critically impact the desired mechanical properties of printed PLA parts.
Design/ Methodology/ Approach: The three selected critical process parameters are simultaneously studied in a systematic manner using a hybrid statistical tool central composite design (CCD) for Response surface methodology. The selected printing parameters are layer thickness, nozzle temperature, and printing speed.
Findings: The best composition of the tensile strength (50.5479 MPa) & flexural strength (95.0163 MPa) has been produced with an RSM predicted model having process parameters layer thickness 0.2313mm, nozzle temperature 208 °C, and printing speed 55.5 mm sec-1 Based on the results of the validating method, by producing an optimal sample in accordance with optimal parameters and their mechanical properties measurements, it was found that the optimal values of parameters are giving the maximum mechanical properties and the RSM Method has a high ability to optimize the parameters.
Research Implications: Tensile Strength and Flexural strength are the two important features that need a stent to withstand the forces exerted on it by the surrounding tissues and blood flow and to be able to bend and conform to the shape of the artery during insertion and deployment. This study focuses on nozzle temperature, printing speed, and layer thickness in the experimental estimation of the ideal PLA polymer FDM part characteristics. Results show that Layer thickness and Nozzle Temperature are the dominating contributors to the mechanical responses (tensile strength & Flexural strength).
The therapeutic effect of Loranthus parasiticus lignans derivatives on collagen-induced arthritis in rats through SHBG/NFκB pathway
Authors: Bai Jiali , Zhang Cong , Liu Yulin , Kuang Nanzhen , Xu Liangquan , Xu Zhengang , Wang Haiwei , Liu Renping
Published: July 2023

Lignan-rich beans, nuts, and various seeds are the main protective food with antioxidative and hormones modulating activity. However, although the role of lignans in mediating hormone-dependent cancers, and cardiovascular disease is well characterized, the function of lignans in anti-arthritic activity and its actual mechanisms remain unknown. A set of three new lignan derivatives named (-)-nortrachelogenin, trachelogenin, and matairesinol were extracted from Loranthus parasiticus. After the establishment of collagen-induced arthritis (CIA) model by intradermal injection of collagen, rats were treated with the mixed three new lignan derivatives ((-)-nortrachelogenin: 37%; trachelogenin: 27%; matairesinol: 25.7%) at a concentration of 50 mg/kg and 100 mg/kg, or methotrexate of 0.3 mg/kg. The mixed lignan derivatives significantly attenuated the immune responses in the joints of CIA rats, resulting in decreased levels of pro-inflammatory cytokine (IL-6, TNF-α) and boosted free androgen in serum compared to the CIA model. The results of molecular docking via the AutoDock Vina showed that lignan derivative (-)-nortrachelogenin is the most effective compound for binding to SHBG, then leading to inhibiting the activity of NFκB in LPS-stimulated macrophages. In this study, (-)-nortrachelogenin was identified as the previously unrecognized anti-inflammatory activity of natural lignan new derivative, and its molecular mechanism is related to the regulating NFκB/SHBG pathway. Our findings suggest further application of sex hormone-like compounds in treating rheumatoid arthritis and potential clinical applications of (-)-nortrachelogenin.
The effect of childhood trauma on social networking websites addiction among Chinese college students: A moderated mediation model of insecure attachment and basic psychological need satisfaction
Authors: Wang Lingli , Chen Yunli , Zhang Wanzhu , Cai Yixi
Published: July 2023

People who experience childhood trauma are prone to developing psychiatric disorders and addictive behaviors. However, the relationship between childhood trauma and specific types of internet use (e.g., social media) has not been exactly proven. This study aims to explain the relationship between childhood trauma and social networking websites addiction by testing the possible mediating role of insecure attachment and the moderating role of basic psychological need satisfaction. A sample of 1281 Chinese college students was tested by using a series of self-report questionnaires on childhood trauma, attachment, basic psychological need satisfaction, and social networking websites addiction. The results showed that the relationship between childhood trauma and social networking websites addiction showed positively, furthermore, attachment anxiety and attachment avoidance mediated this relationship; Moderated mediation analyses showed that the pathway between childhood trauma and social networking websites addiction was moderated by basic psychological need satisfaction. Results suggest college students with Childhood trauma experience and insecure attachment styles may be at higher risk for social networking websites addiction and support intervention efforts for fostering attachment and basic psychological need satisfaction relationship to attenuate the association between childhood trauma experience and social networking websites addiction.
Genetically determined cheese intake and risk of arterial diseases, frailty, and oral disease: a Mendelian randomized study
Authors: Zhang Zhan , Li Jianfeng , Angwen Chenglinlongzhu , Li Xinghui , Wang Bowen , Li Yanling , Wang Rong , Li Ruizhen , Xie Ping
Published: July 2023

Background Observational studies suggest a possible correlation between cheese intake and certain arterial diseases, frailty, and oral disease. However, the causal relationship between them is unclear.Objective The aim of this study was to investigate the possible causal effects of genetic prediction of cheese intake with certain arterial diseases, frailty, and oral disease.Methods This study explored possible causal effects of exposure and outcome based on data from genome-wide association studies in a two-sample Mendelian randomization (MR) study.Results The findings showed that genetically predicted cheese intake was associated with coronary atherosclerosis (odds ratio (OR) = 0.986; 95% confifidence interval (CI): 0.976–0.996; P = 0.0048), peripheral atherosclerosis (OR = 0.558; 95% CI: 0.369–0.843; P = 0.0056), atherosclerosis (excluding cerebral, coronary, and peripheral arteries) (OR = 0.803; 95% CI: 0.741–0.871; P = 0.0427), frailty index (OR = 0.803; 95%CI: 0.746–0.865; P = 9.36E-08), chronic periodontitis (OR = 0.558; 95% CI: 0.349–0.890; P = 0.0145 ) and acute periodontitis(OR = 0.235; 95% CI: 0.062–0.893; P = 0.0335) were negatively associated. Also, no association was observed between cheese intake and cerebral atherosclerosis (OR = 0.909; 95% CI: 0.073–11.288; P = 0.9408) and dental caries (OR = 1.018; 95% CI: 0.676–1.533; P = 0.9337).Conclusion This MR study found a negative association between cheese intake and coronary atherosclerosis, peripheral atherosclerosis, atherosclerosis (excluding cerebral, coronary, and peripheral arteries), frailty, and periodontitis.
Atomic-scale manipulation of buried graphene – SiC interface by local electric field
Authors: Kolmer Marek , Hall Joseph , Chen Shen , Han Yong , Tringides Michael
Published: July 2023

Unprecedent precision of scanning tunneling microscopy (STM) enables control of matter at scales of single atoms. However, transition from atomic-scale manipulation strategies to practical devices encounters fundamental problems in protection of the designer structures formed atop the surface. In this context, STM manipulation of subsurface defects on technologically relevant materials is encouraging. Here, we propose a material platform and experimental protocols for ultimately precise manipulation of a buried interface. We show that an electric field from the STM-tip reversibly controls local coupling between the graphene buffer layer and the SiC substrate under epitaxial bilayer graphene (BLG). This process is vertically defined by the atomically sharp interface, located ~1 nm below the top graphene layer, and laterally by single sites from its (6×6)SiC moiré lattice. Local and reversible electric-field-induced patterning of BLG heterostructure on SiC from its bottom interface creates a novel architecture concept for epitaxial graphene applications.
Multivariate statistical methods for analysis of physicochemical and microbiological parameters of well water from the village M’Pody
Authors: N’Dri Aubin Yao , Assohoun Stanislas Egomli , Okou Cyrille Guei , Gbagbo Georges Aubin Tchapé , Meless Renaud Franck Djedjro , Amin Christophe N’Cho
Published: July 2023

The aim of this article is to analyze well water from the village M’Pody using multivariate statistical analysis methods. Sixteen physicochemical and micro-biological parameters from four well water sampling campaigns in 2020 were analyzed. A descriptive statistical analysis was used to study the non-potability of these waters. Next, a combination of principal component analysis (ACP), facto-rial correspondence analysis (AFC) and Kohonen’s self-organizing map is used to highlight the different well profiles in the study area. Finally, analysis of variance (ANOVA) was used to prove the contribution of these wells on microbiological parameters.
Identification and Analysis of Pivotal Genes in Type 2 Diabetes Mellitus Combined With Non-Alcoholic Fatty Liver Disease
Authors: Xiao Shan , Yang Ye , Wang Qin
Published: July 2023

Objective
Type 2 diabetes combined with non-alcoholic fatty liver disease (NAFLD) rapidly increases the risk of developing cirrhosis or even liver failure in type 2 diabetes, and no drugs have yet emerged to specifically treat this disease. Therefore, it is urgent to find the precise targets for the pathogenesis of type 2 diabetes combined with NAFLD. Thus, this paper uses bioinformatics to analyze the candidate genes involved in diabetes combined with NAFLD and their potential mechanisms.
Methods
GSE49541 was downloaded from the Gene Expression Omnibus (GEO) database to identify differentially expressed genes (DEGs) associated with NAFLD.The DEGs were intersected with the three major metabolism-related genes, and the co-expressed DEGs were subjected to functional enrichment analysis and WGCNA (Weighted Gene Co-Expression Network Analysis) analysis to construct modules closely related to NAFLD in T2DM, thereby screening the target modules for genes and lncRNAs that were significantly enriched,and constructing lncRNA and mRNA co-expression networks related to the metabolism of the three substances. In the Comparative Toxicogenomics Database (CTD), we obtained genes and pathways directly related to NAFLD and T2DM, constructed disease pathways involved in NAFLD and T2DM disease genes, and combined with GSEA analysis to screen out core genes, related lncRNAs and key pathways.
Results
A total of 641 DERs were obtained by differential analysis, and 251 overlapping gene DEGs were obtained by taking intersections in the three major metabolisms, which were analyzed by GO and KEGG enrichment, and these overlapping DEGs were involved in 666 GO analysis and 44 KEGG enrichment analysis results. They were mainly associated with metabolic processes such as lipid metabolism, fatty acid metabolism and amino acid metabolism, PPAR signalling pathway, ketone body synthesis and degradation. The 25 hub genes in the brown module and the 96 hub genes in the turquois module were obtained by WGCNA analysis, respectively. Finally, by constructing a lncRNA-mRNA-KEGG co-expression network, four disease genes (AHCY, PEMT,CYP2E1, GNMT) were obtained as possible candidate biomarkers for type 2 diabetes combined with NAFLD. Six lncRNAs associated with disease genes were also obtained: RAB11B-AS1, LINC01018, LINC01806, LINC00844, NNT-AS1, LINC01128.
Conclusion
The pathogenesis and progression of type 2 diabetes mellitus combined with non-alcoholic fatty liver disease is caused by multiple pathways, which also provides clinicians with potential therapeutic tools for its treatment.
Effect of SARS-CoV-2 infection on IVF/ICSI-ET outcomes: A propensity score-matched cohort study
Authors: Li Yanhui , Ding Xiaofang , Luo Dan , Li Tao , Liu Lin , Li Bingjie , Chen Chunyan , Liu Yi , Ding Hui
Published: July 2023

Background: The SARS-CoV-2 virus is continually evolving, and the worldwide epidemic is still ongoing. There is conflicting evidence regarding how SAS-CoV-2 infection affects the outcomes of assisted reproductive technology (ART). The aim of the current study was to investigate whether the outcomes of in vitro fertilization (IVF) treatment were affected during the acute period of SARS-CoV-2 infection or immediately after recovery from COVID-19.
Methods: In this retrospective cohort study, SARS-CoV-2-infected couples who underwent IVF treatment at Wuhan Union Hospital within the first three months following the lifting of the pandemic policy in mainland China were propensity-score matched (PSM) to uninfected couples who received IVF during the dynamic COVID-zero policy. Following matching, 358 and 698 patients were assigned to the SARS-CoV-2-infected and uninfected groups, respectively. The laboratory and clinical outcomes of the two groups were compared.
Results: The average number of oocytes retrieved, mature oocyte rates, normal fertilization rates, abnormal fertilization rates, and cleavage rates did not differ significantly between the two groups. The blastocyst formation rates were considerably lower in the infected group than in the uninfected group. Stratification by time from SARS-CoV-2 infection to oocyte retrieval (≤ 30, 31-60, 61-90 and ≥90 days) revealed that both blastocyst formation and available blastocyst rates were significantly decreased when oocyte retrieval was performed 31-60 days after SARS-CoV-2 infection. However, after the first embryo transfer cycle, there were no significant differences in the rates of embryo implantation, biochemical pregnancy, clinical pregnancy or early abortion between the two matched cohorts.
Conclusion: SARS-CoV-2 infection had no effect on clinical outcomes after the first embryo transfer cycle; however, the blastocyst formation rate was significantly lower in couples who underwent IVF treatment 31-60 days after SARS-CoV-2 infection, indicating that SARS-CoV-2 infection may still impair embryo developmental potential.
Analysis of nighttime aerosols and relation to covariates over a highly polluted sub- Saharan site using wavelet coherence approach
Authors: Tariq Salman
Published: July 2023

High emissions of aerosols and trace gases during nighttime can cause serious air quality, climate, and health issues, particularly in extremely polluted cities. In this paper, an effort has been made to examine the variations in aerosols and trace gases over a sub-Saharan city of Ilorin (Nigeria) during nighttime. We have used Aerosol Robotik Network data of aerosol optical depth at 500 nm (AOD), Angstrom Exponent (440/870) (AE) and precipitable water (WVC). We also analyzed nighttime data of CO, CH4 and O3 from Atmospheric Infrared Sounder (AIRS), and aerosol subtypes from CALIPSO. AOD, AE, and WVC average values are found to be 0.64 ± 0.33, 0.74 ± 0.24, and 3.40 ± 0.97, respectively. As a result of northeasterly winds carrying Saharan dust during the dry season, the greatest value of AOD was discovered in February. Desert dust aerosols (37.63%) were the most prevalent type, followed by mixed aerosols (44.15%). Winds at a height of 1500 m AGL were likely transporting Saharan dust to Ilorin. CALIPSO images revealed that Ilorin's atmosphere contained dust, polluted continental, clean maritime, and polluted dust on high AOD days. The NOAA's vertical sounding profiles showed that the presence of high AOD values were caused by the inversion layer trapping aerosol pollution. Average nighttime concentrations of CO, O3 and CH4 were measured to be 12718 ppbv, 29.72.1 ppbv, and 1822.612.7 ppbv, respectively. The wavelet coherence spectra exhibited significant quasi-biannual, and quasi-annual oscillations at statistically significant level.
Association between dietary carotenoid intakes and abdominal aortic calcification in adults: National Health and Nutrition Examination Survey 2013 – 2014
Authors: Chen Weidong , Li Yuanqing , Li Min , Li Hai , Chen Caifang , Lin Yanzhao
Published: July 2023

Objective: Abdominal aortic calcification (AAC) is an important marker of subclinical atherosclerosis and a predictor of cardiovascular disease. This study aims to explore the association between carotenoid intakes and AAC.
Methods: We included 2889 participants from the National Health and Nutrition Examination Survey (NHANES). Dietary carotenoid intakes were obtained through 24-h dietary recall interviews. Severe AAC was defined as a Kauppila score > 5. The main analysis utilizes logistic and restricted cubic spline models.
Result: Severe AAC was detected in 378 (13.08%) participants. In fully adjusted models, the odds ratios (OR) with 95% confidence intervals (CI) of α-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein with zeaxanthin, and total carotenoid intakes for individuals with severe AAC were 0.53 (0.23 to 0.77), 0.39 (0.19 to 0.80), 0.18 (0.05 to 0.62), 0.40 (0.20 to 0.78), 0.53 (0.32 to 0.88) and 0.38 (0.18 to 0.77) in the highest versus lowest quartile intake, respectively. Dose-response analyses revealed that all of the carotenoids were associated with decreased risk of severe AAC in a nonlinear trend. Total carotenoid intakes of at least 100ug/kg/day was associated with decreased odds for severe AAC.
Conclusion: α-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein with zeaxanthin, and total carotenoids were inversely associated with the risk of severe AAC in adults.
Variable Importance Measures for Variable Selection and Statistical Inference in Multivariate Random Forests
Authors: Sikdar Sharmistha , Hooker Giles , Kadiyali Vrinda
Published: July 2023

Multivariate random forests (or MVRFs) are an extension of tree-based ensembles to examine multivariate responses. MVRF can be particularly helpful where some of the responses exhibit sparse (i.e., zero-inflated) distributions, making borrowing strength from correlated features attractive. Tree-based algorithms select features using variable importance measures (VIMs) that score each covariate based on the strength of dependence of the model on that variable. In this paper, we develop and propose new VIMs for MVRFs. Specifically, we focus on the variable’s ability to achieve split improvement, i.e., the difference in the responses between the left and right nodes obtained after splitting the parent node, for a multivariate response. Our proposed VIMs are an improvement over the default VIM in existing software that are based on naïve measures like frequency of variable usage in an MVRF and allow us to investigate the strength of dependence both globally and on a per-response basis. Our simulation studies show that our proposed VIM recovers the true predictors better than naïve measures. We demonstrate usage of the proposed VIMs for variable selection in two empirical applications; the first is on Amazon Marketplace data to predict Buy Box prices of multiple brands in a category, and the second is on ecology data to predict co-occurrence of multiple, rare bird species. A feature of both data sets is that some outcomes are sparse – exhibiting a substantial proportion of zero values. In both cases the proposed VIMs when used for variable screening give superior predictive accuracy over naïve measures.
Submersible pumpset failure prediction using artificial intelligence methods
Authors: Shakirova E. V. , Semykin M. V.
Published: July 2023

It is well-known that large amounts of data are collected and processed during the operation of electric submersible pumps. To optimize the work of mining control center operators, it is recommended to use an automated emergency prevention system. In this way, operators will be able to receive timely information about possible equipment failures, which in its turn will increase the service life of the equipment and reduce operating costs for repairs. The purpose of the present research is to develop a model predicting submersible pumping equipment failures using the method of artificial intelligence. To identify the most accurate model, the paper compares the following forecasting methods: the nearest neighbour method and the linear classifier building method. The presented correlation was created on the basis of 30 parameters obtained from 272 wells of the Eastern Siberia field. Being used, it enabled error-free prediction of failures and complications in pumping equipment operation depending on the gas factor and frequency. Thus, the developed model can be used by oil and gas enterprises to predict failures and accidents in the operation of submersible pumping equipment. The conducted study shows that the prediction accuracy of the required parameter in the developed artificial intelligence model exceeds the results of conventional statistical methods. The model also can be useful for future optimization of processes when field planning and developing. Artificial intelligence is the best prediction method of submersible pumping equipment failures, due to its high speed and accuracy, cognitive technologies are widely used in big data processing.
Antioxidant effects of Green tea and Black tea from Ungpo Region
Authors:   Association for International Tea Culture, Sohn Yeun-sook , Jung Su-young
Published: July 2023

Ungpo region in Iksan, Jeonbuk of South Korea is the uppermost limit of wether for cultivating tea. This study focuses on analyzing biologically active constituents and antioxidant effects of green and black tea from Ungpo to brighten hidden zone of related tea studies. Firstly, we starts from examining total polyphenol and flavonoid contents of Green Tea extracts(GTE) and Black tea extracts(BTE) from Ungpo and evaluating the possible antioxidant activities from its extracts. Therefore, we could measur the effects of GTE and BTE on vitalizing activities against DPPH radical and ABTS radical. These results indicate that GTE and BTE protects oxidative activities through activating free radials.
Features of molecular genetic diagnosis of retinoblastoma
Authors: Zelenova E. E. , Kozlova V. M. , Yugay O. V. , Kyun Yu. A. , Ushakova T. L. , Mikhailova S. N. , Alekseeva E. A. , Musatova V. V.
Published: July 2023

Retinoblastoma (RB) is one of the most common malignant neoplasms of the visual organ in children, with an established genetic factor in the development of the disease. The detection of mutations in the RB1 gene has been successfully carried out for many years, however, the development of technologies for DNA diagnostics of RB allows us to consider this disease not only as an independent tumor, but also as one of the manifestations of more complicated genetic syndromes involving a complex of genes. The correct genetic diagnosis is important to understand the prognosis of the health of a patient with RB and recommendations for his further observation, as well as a correct assessment of the risks of having children with the same pathology in the family.

Currently available methods of DNA diagnostics of the RB1 gene are new generation sequencing (NGS) and multiplex amplification of ligated probes (MLPA). However, in some cases, additional diagnostics may be required – a karyotype study or chromosomal micromatrix analysis (CMA). In this article we present a molecular genetic study of children with uni- and bilateral RB with an extended deletion at the RB1 gene locus. The aim of the study was determining of possible indications for the appointment of extended DNA diagnostics.
Possibilities of physiotherapy in the rehabilitation of children and adolescents who have undergone oncohematological diseases
Authors: Zhukovskaya E. V. , Filippova N. Ye. , Volkov D. A. , Karelin A. F.
Published: July 2023

Background. The success of pediatric oncohematology makes the rehabilitation of cured patients more and more relevant. Physiotherapy for cancer patients is an underdeveloped method of treatment.

The purpose of the study – to analyze the use of physiotherapy techniques in the rehabilitation practice of pediatric oncologists, hematologists.

Materials and methods. The authors completed their research based on the materials of the activities of the Department of Physiotherapy of the Clinical Rehabilitation Research Center “Russian Field” for the period 2018–2021.

Results and discussion. Approximately 2,000 patients per year with oncohematological diseases during the period of remission receive evidence-based physiotherapeutic methods of treatment (electrotherapy, inhalations, magnetotherapy, balneotherapy, massage). Doctors note the effectiveness and safety of the therapy.

Conclusion. Knowledge of the evidence-based basis of physiotherapy treatment allows doctors to choose an adequate method and increase the effectiveness of rehabilitation.
Synthesis and Characterization of Carbon Nano Sphere-doped Gd: Alpha
Sb2O4 Nanostructure for High-Performance Energy Storage Applications
Authors: Adimule Vinayak , Lakshminarayana Parashuram , Sharma Kalpana , Manhas Nidhi , Nabgan Walid
Published: July 2023

Background:

To enhance the super capacitive properties of nanocomposites, the effective
method is to combine carbon nanospheres with mesoporous structures with Gd3+:α-Sb2O4
inorganic nanocomposites (NC) to form hybrid electrodes. An as-prepared hybrid electrode material
possesses increased energy density, high rate of reversibility and cyclic stability when
incorporated in electrochemical cyclic voltammetric studies.

Methods:

In the present investigation, various wt % of C-nanospheres (Cx) (5 %, 10% and 20%)
were decorated over Gd3+: α-Sb2O4 nanocomposites and were synthesized by coprecipitation
method. XRD, SEM, EDX, UV-visible, and XPS are only a few of the analytical techniques
used to describe the as-prepared hybrid nanocomposites. Electrochemical cyclic voltammetry
was carried out in a 6 M KOH solution, three-electrode system.

Results:

The crystal structure and morphology of Cx: Gd3+@ α-Sb2O4 NC showed a mixed hexagonal
phase and agglomerated tiny irregularly shaped morphology that appeared as the Cx concentration
increased. Redshift in optical absorption peak appeared (near UV-edge), and the optical
band gap (Eg) value increased from 3.53 eV to 3.65 eV. The electrochemical supercapacitor
showed the highest specific capacitance of 989 F/g at the current density of 1 A/g for
C20%:Gd3+@α-Sb2O4 NC compared with Cx:Gd3+@α-Sb2O4 (x = 5% and 10%) and undoped
Gd3+:α-Sb2O4 NC. The change in phase angle and Rs value of 1.98 was attributed to the ideal
supercapacitor properties. The cyclic stability after 5000 cycles with 79.71% capacitive retention
was exhibited by C20%:Gd3+@α-Sb2O4 NC.

Conclusion:

The present research introduces ease of synthesis of hybrid electrode materials
possessing high active surface area, increased energy density, high cyclic stability, and reversibility
in an aqueous solution.
OTT Services and Intention to Continuous Subscription: A Moderated-Moderated Mediation Analysis
Authors: Jaiswal Shefali , Singh Anurag
Published: July 2023

Drawing on the search experience, the study investigates the impact of Over-the-top Services on their intention to continuous subscription. It investigates the mediation of search experience on the linkage between Over-the-top Services (OTT) and intention to continuous subscription. Moreover, study examines the Moderated Mediation effect of screen watching time (first moderator) and device (second moderator) in the relationship of Over-the-top Services, Intention to Continuous Subscription, and Search Experience. An online survey was used to collect the responses and 405 responses were considered for the study. The analysis shows that OTTservices has a significant impact on its user search experience which in turn also has strong and positive impact on the intention to continuous subscription by its users. It was also discovered that the screen watching time as its role of two way interaction has significant moderating effect between OTTservice and search experience relationship and search experience and intention to continuous subscription relationship. The three-way interaction between device and screen watching time in the mediation model was analysed & found strong support in the relationship between OTTservices and search experience and search experience & intention to continuous subscription. This is one of the few paper to check the inter-relationship between OTTservices, intention to continuous subscription and search experience. The three-way interaction between mediation model and screen watching time (first moderator) and device (second moderator) is studied for the first time in the literature therefore the findings will originate the value with novelty and important implications to the OTTconsumers, and content providers.
Robot-assisted cystectomy in treatment of patients with bladder urothelial carcinoma
Authors: Oganyan V. A. , Simonov A. D. , Karelskaya N. A. , Kochetov A. G. , Monakov D. M. , Gritskevich А. A.
Published: July 2023

The article presents an assessment of the results of surgical treatment of bladder urothelial carcinoma using the Da Vinci Si robotic system. The experience of treating 11 patients who underwent robot-assisted cystectomy (RACE) was analysed. This study demonstrates the effectiveness of RACE due to minimal trauma, blood loss, transfusion frequency, and length of patient stay in the hospital.
Laparoscopic radical prostatectomy with sparing of the proximal prostatic urethra
Authors: Eremenko S. N. , Mikhaylichenko V. Yu. , Eremenko A. N. , Dolgopolov V. P. , Kozak A. A. , Chernega V. S. , Aliyev M. A.
Published: July 2023

Introduction. The most common treatment option for prostate cancer is radical prostatectomy, which involves the removal of the prostate itself and the prostatic urethra in a single block, followed by the formation of a vesicourethral anastomosis. This approach is fraught with postoperative complications, such as urinary incontinence and strictures of anastomosis. In this sense, the clinic's staff faced the question of the possibility of a urethral-sparing variant of operative benefit for a certain category of patients.

Objective. To assess the possibility of performing radical prostatectomy with sparing of the proximal prostatic urethra in the laparoscopic version, its advantages, and disadvantages.

Materials & methods. From 2021 to 2022, 18 successful laparoscopic operations were performed using this technique at the St. Luke Clinical Multidisciplinary Medical Centre. Patients were selected according to the above criteria. In the preoperative period, patients underwent a standard examination in accordance with guidelines, including a blood test for prostate-specific antigen (PSA), ultrasound, magnetic resonance imaging (MRI) with 3D-modelling, data from a multifocal prostate biopsy, the International Prostate Symptom Score (IPSS), the International Index of Erectile Function (IIEF), the Quality of Life (QoL) index due to urinary disorders, assessment by the Partin’s nomogram. Intraoperative ratios, early and late postoperative complications, length of hospital stay, day of catheter removal, and time to complete urethral recovery were evaluated to study the effectiveness of this surgery type. PSA testing, uroflowmetry with post-void residual urine measurement and IPSS questionnaire were carried out one month after surgery.

Results. There was an improvement in all measurements one month after surgery: median values of the mean urine flow rate increased by 1.7 ml/s, median values of the max urine flow rate increased by 3.7 ml/s, the IPSS decreased by 12 points.

Conclusion. Based on the results of the study, clinical observations, and statistical analysis of the data obtained, it can be concluded that laparoscopic radical prostatectomy with sparing of the proximal prostatic urethra is the preferred surgical option for this pathology, due to its organ-preserving nature.
Static MRI for diagnosis of bulbous urethral strictures and assessment of spongiofibrosis grade
Authors: Bogdanov A. B. , Katibov M. I. , Veliev E. I. , Monakov D. M. , Goncharuk D. A. , Akhverdieva G. I. , Polyakova A. S. , Vardanyan V. A.
Published: July 2023

Introduction. Insufficient sensitivity and specificity of existing methods for diagnosing urethral stricture require more accurate methods, which may include magnetic resonance imaging (MRI).

Objective. To study the possibilities of MRI to assess the extent of bulbous urethral stricture and spongiofibrosis grade.

Materials & methods. The study included six men with bulbous urethral stricture, who underwent non-transecting anastomotic urethroplasty via ventral approach. Before surgery, all patients underwent retrograde urethrography according to the standard method and urethral MRI according to their own method, and their data were compared with intraoperative parameters.

Results. The length of the stricture according to retrograde urethrography averaged 11.5 ± 6.3 mm, MRI — 17.8 ± 10.9 mm, intraoperative measurement — 16.7 ± 9.1 mm. There was a significant difference between the mean length of the stricture according to retrograde urethrography and the mean length according to intraoperative data (p = 0.028). There was no significant difference between the mean stricture length according to MRI data and the mean stricture length according to intraoperative data (p = 0.085). The length of spongiofibrosis according to MRI was 15.8 ± 13.6 mm on average, and 16.7 ± 12.9 mm according to intraoperative measurements. There was no significant difference between the average length of spongiofibrosis according to MRI and the average length according to intraoperative data (p = 0.092).

Conclusions. MRI provides information comparable to intraoperative data on the extent of urethral stricture, location, and spongiofibrosis grade.
The role of electroneuromyography evaluation of the bulbocavernosal reflex in the diagnosis of pelvic nerve damage in patients with chronic pelvic pain syndrome
Authors: Labetov I. A. , Kovalev G. V. , Volkova O. V. , Shakirova R. R. , Berdichevskaya A. A. , Shkarupa D. D.
Published: July 2023

Introduction. One of the additional instrumental methods for diagnosing pudendal neuropathy is needle electroneuromyography (ENMG) of the bulbocavernosus reflex (BCR). The accumulated data on ENMG BCR in patients with primary chronic pelvic pain syndrome (CPPS) are insufficient due to the specificity of the procedure and its performance only in expert centres that specialise in the treatment of pelvic pain. Therefore, a study to investigate the features of ENMG BCR in patients with CPPS is of increased interest.

Objective. To assess the representativeness and informativeness of the ENMG BCR technique in patients with CPPS and to identify factors influencing changes in the main parameters of the BCR M-response such as latency, amplitude, and duration.

Materials & methods. Retrospective cohort study, which included 75 data from patients with (CPPS) who underwent needle-guided ENMG recording of BCR. Subjective complaints of patients were recorded using validated questionnaires: visual analogue scale (VAS) and chronic prostatitis and male pelvic pain syndrome symptom scale index (NIH-CPSI). Basic ENMG parameters such as the amplitude, latency, and duration of the M-responses were recorded.

Results. We found statistically significant correlations between the duration and height of the M response of the patients (r = 0.31, p = 0.03) and their body weight (r = 0.34, p = 0.02). Anthropometric data did not correlate with amplitude and latency. Significant excess latency above 45 ms was observed, confirming nerve tissue destruction, in 11 (55%) women and 24 (44%) men. Although there were no statistically significant differences in any of the M-response parameters between men and women, there was a tendency for an increase in response amplitude in men and an increase in BCR latency time in women.

Conclusion. The results of our study show that the duration of the M-response of BCR can correlate positively with the anthropometric data of the patient. At the same time, the mean latency and amplitude of the response are independent of anthropometric data, and the difference between them may be more determined by sex differences.
Combined treatment of idiopathic male infertility using low-intensity laser therapy and complex prostate peptides: single-centre experience
Authors: Potapova M. K. , Borovets S. Yu. , Al-Shukri S. Kh.
Published: July 2023

Introduction. The study of effective and safe combined methods of conservative treatment of idiopathic male infertility is of great interest.

Objective. To evaluate the effectiveness of the combined use of low-level laser therapy (LLLT) in the infrared (IR) spectrum and bioregulatory therapy with complex prostate peptides on the semen parameters and sperm DNA fragmentation (SDNAF) in men with idiopathic infertility.

Materials & methods. The study is based on the results of examination and treatment of 97 men with idiopathic infertility. Prior to the start of treatment, all patients were divided into three groups by randomization. Patients in group 1 (n = 34) underwent a course of LLLT in the IR spectrum consisting of 10 procedures q.o.d. Patients in group 2 (n = 31) were prescribed complex prostate peptides Supp. Prostatilen® AC (30 + 180 mg) PR q.h.s. FXD, with a repeat of the course of treatment after 5 days. Patients in group 3 (n = 32) underwent combined treatment: LLLT sessions in the IR spectrum (10 procedures q.o.d.) and a course of Supp. Prostatilen® AC (30 + 180 mg) PR q.h.s. FXD, with a repeat of the course of treatment with peptides according to the same scheme after 5 days. Control examination of patients in all groups was carried out two months after the end of treatment.

Results. As a result of treatment of patients in groups 1, 2, and 3, a significant improvement in the main semen parameters, a decrease in the grade of pathological SDNAF, an increase in serum total and free testosterone concentration (p < 0.05) were observed. A comparative statistical analysis of the results obtained in three groups of patients showed that the combined treatment of patients of group 3, who were prescribed a course of LLLT in combination with complex prostate peptides Supp. Prostatilen® AC, was significantly more effective in improving concentration (p < 0.01) and progressive sperm motility (p < 0.01), as well as a decrease in the grade of pathological SDNAF (p < 0.05), than in groups 1 and 2.

Conclusion. Combined therapy that includes complex prostate peptides and LLLT in the IR spectrum improves the main semen parameters and reduces the grade of pathological SDNAF in men with idiopathic infertility.