bluuebunny/crossref_metadata_2025 huggingface dataset:
Arquitectura Empresarial Para Pymes: Caso SIGED
Authors: Amaya-Corredor Yesid Alejandro , Bolaño-Rocha Eder Fernando , Arias-Quintero Pedro Alberto , Martínez-Ardila Andrea Cristina
Published: February 2025

El diseño de arquitecturas empresariales (AE) es un ejercicio continuo y no de una única vez para el negocio, si bien parecería que es una necesidad propia de las grandes empresas, las PYMES han de adoptar ejercicios de arquitectura empresarial a medida que quieren expandir y transformar sus negocios para ofrecer productos y servicios con condiciones de mercado competitivas y también ante demandas como la ciberseguridad, un tema relevante que requiere el rediseño y enfoque de las capacidades, en el caso SIGED (Sistema de gestión Documental) dicha motivación plantea una interesante ruta de transformación con este ejercicio. El proyecto aborda el diseño de un modelo de arquitectura empresarial bajo la metodología TOGAF, desde la fase A hasta la E, del Software SIGED, para lograrlo se crean los diagramas, matrices y otros documentos que apoyen la gestión de la arquitectura objetivo y el plan de arquitectura resultado para cumplir con el objetivo de dar capacidades para la ciberseguridad en el software de SIGED, la investigación permitió entender procesos de la empresa, prioridades estratégicas planteadas y oportunidades de mejora para construir una visión de arquitectura acorde con las capacidades actuales tanto del recurso humano, tecnológico y procesos, así como la proyección de estos mismos.
Correlation of Immune Parameters in Breast Cancer Patients Undergoing General Anesthesia: post-hoc Analysis of the TeMP Study
Authors: Kadantseva Kristina K. , Subbotin Valery V. , Yadgarov Mikhail Y. , Korolenok Elizaveta M. , Berikashvili Levan B. , Akchulpanov Roman A. , Karnaukhov Nikolay S. , Korchagina Ksenia S. , Kukina Polina I. , Svitich Oksana A. , Kuzovlev Artem N. , Barmina Anna S. , Likhvantsev Valery V.
Published: February 2025

Aim: to study the correlation of immune parameters in breast cancer patients undergoing general anesthesia and to evaluate the 1-year overall and recurrence-free survival after surgery depending on general anesthesia technique.

Materials and Methods. A post hoc analysis of data from a double-blind, randomized, controlled clinical trial involving 98 patients with operable breast cancer was performed. Patients were divided into two groups: 48 received inhalational anesthesia (IA) and 50 received total intravenous anesthesia (TIVA). Immune parameters (CRP, IgA, IgM, IgG, C3, C4, MMP-9, neutrophil and lymphocyte counts, etc.) were assessed before induction of anesthesia, 1 hour postoperatively, and 24 hours postoperatively. Spearman correlation coefficients and heat maps were used for analysis.

Results. In the IA group, significant uniform increases were observed in all immunoglobulin types at 1 and 24 hours postoperatively (all P<0.001; for IgA-IgG, R=0.928; for IgA-IgM, R=0.837; for IgG-IgM, R=0.815). A positive correlation was found between complement components (C3, C4) and immunoglobulins (P=0.011 — 0.023; R=0.313–0.363). In the TIVA group, changes were variable: immunoglobulin levels increased at 1 hour (P<0.001) but decreased at 24 hours (P<0.001). A strong positive correlation was identified between cytotoxic T cells and NK cells (P0.001; R=0.722). Neutrophil count showed no significant correlation with cytotoxic T or NK cells. One year after surgery, both groups demonstrated 100% overall and recurrence-free survival.

Conclusion. IA was associated with synchronized changes in humoral immunity components, whereas TIVA resulted in variable immune responses, suggesting potential differences in IA and TIVA effects on the immune system. However, no impact of anesthesia technique on overall or recurrence-free survival was observed. More research is needed to better understand how different anesthetics affect immune function and the potential impact of anesthesia technique on long-term cancer outcomes.
Edad, género y academia. Mujeres en la Universidad
Authors: González Vaquerizo Helena , Ochoa Díaz Diana , Pérez Ortiz Laura
Published: February 2025

Este volumen colectivo tiempo como onjetivo hacer una contribución a los estudios feministas y más específicamente a la reflexión sobre la intersección ente la edad y el género en la academia. Siempre desde una perspectiva crítica y desde el rigor científico, los distintos capítulos abordan temas como las dificultades en el acceso y la consolidación de la carrera académica de las mujeres, las experiencias de las mujeres jóvenes y en etapas tempranas, o las trayectorias académicas de mujeres pioneras. Las autoras de la obra, profesoras e investigadoras procedentes de diferentes ramas del conocimiento y pertenecientes a generaciones diversas, logran así acercarnos a los debates fundamentales del feminismo en el contexto universitario, al tiempo que adelantan propuestas encaminadas a avanzar en una verdadera igualdad de género en los intereses académicos y desarrollo profesional de hombres y mujeres.
X-ray Computed Microtomography for the Inspection of Flexible Risers
Authors: José da Penha Moreira Adriana , Araújo O. M. O. , Machado A. S. , Lopes R. T. , Oliveira D. F.
Published: February 2025

The integrity of flexible risers, essential for transporting oil from wells to platforms, is often compromised by residual gases such as CO2 and H2S, which cause fatigue through corrosion. The marine environment, with its bending loads, radial forces, and internal and external pressures, intensifies this process, requiring continuous monitoring and maintenance to prevent the degradation of the metallic layers. Flexible risers are composed of polymeric and metallic barriers, each with specific functions to ensure flexibility and pressure resistance. However, the rupture of wires in the tensile armor layers, often initiated by manufacturing defects, represents a significant failure mechanism. A gap has been identified in current inspection methods, which are intrusive or have limited sensitivity in some regions of the risers. To address this issue, the use of X-ray Computed Microtomography (microCT) is proposed as a non-invasive technique to detect microcracks in the layers of flexible risers. In this study, a section of flexible riser 440 mm in length and 155 mm in diameter was scanned by the Phoenix V|tome|x M/Waygate Technologies microtomograph, which has a 500 W range microfocus tube and a GE PXR250RT detector with a pixel size of 200 µm. Subsequently, the projections were reconstructed, and the images were analyzed in specialized software. The results showed defects along all layers of the riser. The application of microCT to enhance defect detection is suggested, which could contribute to safer and more reliable offshore oil and gas operations.
X-ray radiographic analysis of the two wooden sculptures of 18th century
Authors: Azeredo Soraia , Oliveira Renan , Gusmão Elaine , Anjos Marcelino , Sanches Francis , Lopes Ricardo , Oliveira Davi
Published: February 2025

The X-ray radiography technique is highly efficient in investigating the manufacturing techniques employed by an artisan when creating a sculpture, as well as assessing the state of conservation and restoration processes. For instance, it allows the determination of whether the artist carved the sculpture from a single piece of massive wood or if it was sculpted in multiple parts, subsequently assembled using nails, hooks, or metal spikes. It also provides insights into whether the artwork underwent certain restoration processes and reveals its current state of preservation or degradation. This information can offer insights into the artist preferred creation technique, potentially the most popular technique of the time. It can also help estimate the period when the artwork underwent restoration and aid in choosing the appropriate restoration technique. In this study, we present the results of an investigative analysis of the internal structure, using digital X-ray radiography, of two wooden sacred sculptures representing biblical characters King David and his wife Bathsheba, dating back to the 18th century and housed in the Church of Our Lady of Pilar in Duque de Caxias, RJ, Brazil. Both sculptures are covered with layers of stain, with a prevailing golden hue on the garments. The obtained radiographic images show that the artist carved various parts of the sculptures and later assembled them using metal pegs. Additionally, recent nails were visible, indicating that the sculptures underwent a restoration process. All digital radiographic images were captured in high resolution using a flat-panel detector.
Strategic planning of the post-war industrial development: new determinants and imperatives
Authors:   State Organization "Institute for Economics and Forecasting of the National Academy of Sciences of Ukraine", Deineko Liudmyla , Tsyplitska Olena ,   State Organization "Institute for Economics and Forecasting of the National Academy of Sciences of Ukraine", Kushnirenko Oksana ,   State Organization "Institute for Economics and Forecasting of the National Academy of Sciences of Ukraine", Snigova Olena ,   State Organization "Institute for Economics and Forecasting of the National Academy of Sciences of Ukraine", Hakhovych Nataliia ,   State Organization "Institute for Economics and Forecasting of the National Academy of Sciences of Ukraine", Sheludko Ella ,   State Organization "Institute for Economics and Forecasting of the National Academy of Sciences of Ukraine", Venger Liliia ,   State Organization "Institute for Economics and Forecasting of the National Academy of Sciences of Ukraine", Deineko Olexsandr ,   Ukrainian-American Concordia University, Zavgorodnia Mariia ,   State Organization "Institute for Economics and Forecasting of the National Academy of Sciences of Ukraine", Zarudna Olha ,   State Organization "Institute for Economics and Forecasting of the National Academy of Sciences of Ukraine"
Published: February 2025

The monograph examines the state and highlights the main issues and objectives of regulatory, instructional and methodological support for long-term strategic planning in Ukraine. Significant attention is paid to presenting international experience in the strategic planning of industrial and sectoral development. It explores the determinants and imperatives of Ukraine’s industrial development amidst the high level of uncertainty caused by the ongoing Russian military aggression and global instability. The strategic priorities for post-war recovery are highlighted from the perspective of key stakeholders.
For professionals in public and industrial management, researchers, teachers, students and post-graduate students in economics and other fields.
Ultra-fast eco-friendly UHPLC–MS/MS methodology for the quantification of ASP3026 in human liver microsomes: Evaluation of metabolic stability via in silico software and in vitro metabolic incubation
Authors: Attwa Mohamed W. , Abdelhameed Ali S. , Kadi Adnan A.
Published: February 2025

ASP3026 is a recently formulated and highly selective inhibitor designed to target the ALK kinase. ASP3026 efficiently inhibited ALK kinase activity and demonstrated superior selectivity at a panel of Tyr-kinases compared to crizotinib. The target of this investigation was to establish a highly accurate, fast, green, and highly sensitive Ultra-high performance liquid chromatography- Tandem mass spectrometry (UHPLC-MS/MS) technique for assessing the concentration of ASP3026 in human liver microsomes (HLMs). In vitro incubation, the metabolic stability of ASP3026 in HLMs was evaluated using this known approach. The validation steps for the UHPLC-MS/MS analytical technique in the HLMs were performed along with the bio-analytical method validation guidelines settled by the US-FDA. To increase the ecological sustainability of the current UHPLC-MS/MS system, a lower flow rate of 0.3 mL min−1, a shorter elution duration of 1 min, and a reduced consumption of ACN have been implemented. A screening of the chemical structure of ASP3026 for hazardous alerts and metabolic lability was performed by the StarDrop package, that includes the DEREK and P450 modules. The analytical separation of ASP3026 and fenebrutinib (FNB) on the reversed phase Eclipse Plus C18 column was performed using an isocratic mobile phase approach. The calibration curve produced by the ASP3026 showed a linear association over the level range of 1–3,000 ng mL−1. A study was conducted to evaluate the precision and accuracy of UHPLC-MS/MS technology in evaluating both intra-day and inter-day variations. The accuracy exhibited a range of −1.56%–7.33% across various days, and a range of −0.78%–10.66% within the same day. The ASP3026 underwent in vitro half-life and intrinsic clearance measurements, yielding values of 14.32 min and 56.62 mL min−1 kg−1, correspondingly. According to in silico software research, using minor modifications to the piperazine component or substituting the group in drug design has the potential to improve the metabolic safety and stability of novel derivatives in comparison to ASP3026.
Public priorities in psychedelics research
Authors: Bălăeţ Maria
Published: February 2025

This commentary explores public priorities in psychedelic research, drawing insights from extensive conversations between the author and the general public during lectures and seminars across the UK. Two primary themes emerged from this exchange: areas where further research is desired and concerns about the current direction of psychedelic research. Key topics of interest include psychedelics' effects on neurodivergent individuals, ageing, pain management, cognitive enhancement, psychosis, and interactions with the female menstrual cycle. Areas of concern pertain to the involvement of pharmaceutical companies in psychedelics research, the potential medicalisation of psychedelics, and the growing interest in psychedelic tourism. The commentary emphasises the need for a constant dialogue between scientists and the public, critical engagement with research and the integration of diverse perspectives in order to foster a broader understanding of psychedelics and their potential applications in this rapidly evolving field.
Dundry Stone and Other Limestones in The Fabric, Fittings, and Monuments of St Davids Cathedral
Authors: Palmer Tim
Published: February 2025

Although St Davids is remote from other parts of Britain by the overland route, it has always been readily accessible by sea. Freestones, quarried and worked at faraway sites and typically transported by sea and river, are frequently encountered in medieval ecclesiastical buildings,
where they were used for structure, decoration, and monuments. Polishable limestones (marbles) were similarly transported over large distances for a similar range of functions. With a little specialist knowledge these materials are usually readily identifiable. Hence they may give informa-
tion about extraction, craft activity and supply routes, as well as about architectural practices and ownership links to source areas, at certain times in a building's history. This article summarises the variety of lime- stones and marbles that were brought from outside the area, doubtless
by sea, to be used in the cathedral at St Davids, up to the time of the Reformation.
ÇOK KUTUPLU ULUSLARARASI SİSTEMDE STRATEJİK OTONOMİ KAVRAMI VE ÖNEMİ
Authors: Çakırca Burak
Published: February 2025

Uluslararası siyaset sahnesinde yaşanan gelişmeler, uluslararası sistemin yapısının ne olduğu konusunda tartışmaların ortaya çıkmasına yol açmıştır. 2.Dünya Savaşı ile birlikte ABD hegemonyasında kurulan liberal uluslararası sistemin, Soğuk Savaş’ın bitişiyle birlikte mutlak zafer kazandığı ve uluslararası sistemin tek kutuplu bir hali ifade ettiği kabul edilmektedir. Ancak tarihsel süreç içerisinde yaşanan gelişmeler ve yeni yükselen güçlerin varlığı, uluslararası sistemin çok kutuplu bir yapıya karşılık geldiği kabulünü ortaya çıkarmıştır. Özellikle Koronavirüs pandemisi ve Ukrayna-Rusya savaşında liberal uluslararası sistemin yapıtaşlarından olan uluslararası örgütler etkisiz kalmıştır. Bu durum çok kutupluluğun da tescili olacak biçimde ulus-devletlerin yeniden uluslararası siyasetin temel aktörleri haline gelmesine yol açmıştır. Diğer yandan çok kutupluluk kendi kendine yardım ilkesini de bir zorunluluk haline dönüştürmüştür. Stratejik otonomi kavramı devletlerin bağımlılıklarını gidermek ve en uygun seçeneği belirleyebilmek için dengeleme davranışı olarak tanımlanabilir. Bu noktada bu çalışma, stratejik otonomi kavramının çok kutuplu uluslararası sistemde devletlerin dış politika tercihlerinde uygun bir davranış olup olmadığı sorusunu merkeze almaktadır.
YEŞİL ENERJİ VE YEŞİL BEŞERİ SERMAYE AVRUPA BİRLİĞİ ÜLKELERİNDE ÇEVRE KALİTESİNİN GELİŞMESİNE KATKI SUNAR MI?
Authors: Atay Polat Melike , Ergün Suzan
Published: February 2025

Ekonomik büyüme temel makroekonomik hedeflerin başında gelir ve dünya çapındaki ekonomistlerin odak noktalarından birini oluşturur. Diğer yandan ekonomik büyüme için gerekli kaynakların neredeyse tamamı çevre kirliliğine neden olmaktadır. Bu nedenle küresel ekonominin gelişmesiyle birlikte çevre sorunları ciddi boyutlara ulaşmış ve çeşitli uluslararası kuruluşları ve ülkeleri endişelendirmiştir. Her geçen gün artan çevre kirliliği ve neden olduğu olumsuzluklar ülkeleri bu soruna çözümler bulmaya mecbur bırakmaktadır. Dolayısıyla çevre kalitesine katkı yapacak faktörlerin belirlenmesi sürdürülebilir büyüme için kritik öneme sahiptir. Bu çalışma yeşil enerji ve yeşil beşeri sermayenin çevre kalitesi üzerindeki etkilerini Avrupa Birliği örneğinde incelemiştir. Analizlerde ikinci nesil panel veri testleri kullanılmıştır. Eşbütünleşme testi bulgularına göre değişkenler arasındaki uzun dönem ilişkinin belirlenmesinin ardından, eşbütünleşme katsayılarını tahmin etmek için FMOLS ve DOLS tahmincilerine başvurulmuştur. İlgili tahmincilerin bulgularına göre AB ülkelerinde yeşil beşeri sermaye ve yeşil enerji çevresel kaliteyi iyileştirirken, doğal kaynaklar çevresel kirliliği artırmaktadır. Son olarak Dumitrescu-Hurlin nedensellik bulguları değişkenler arasında çeşitli nedensellik ilişkisini doğrulamıştır.
11. KALKINMA PLANI HEDEFLERİ VE SÜRDÜRÜLEBİLİR KALKINMA AMAÇLARI DOĞRULTUSUNDA DEĞERLENDİRİLMESİ
Authors: Gürsoy Ayşegül , Erbuğa Gökçe Sinem
Published: February 2025

Türkiye, sürdürülebilir kalkınmayı gerçekleştirmek adına 11. Kalkınma Planı ışığında kendine uzun soluklu amaçlar belirlemiştir. Söz konusu amaçlara erişme doğrultusunda her ne kadar iktisadi ve politik iklimin sürekli olarak değişmesi söz konusu olsa da Türkiye, amaçlarına ulaşma yolunda dengeli ve kararlı bir biçimde ilerlemektedir. Küresel ölçekte karşılaşılan iktisadi ve finansal belirsizliklerin artışı ve bu risklerin beraberinde getirmiş olduğu çok çeşitli riskler, kalkınma planlarını önemli hale getirmiştir. Bu risklerin sağlıklı bir biçimde yönetilebilmesi adına hazırlanmakta olan kalkınma planları, ulusların istikrarlı ve planlı bir sürdürülebilir kalkınma stratejisi izlemesine olanak vermektedir. Küresel boyutta teknolojik bilgi, beceri ve gücü elinde bulunduran uluslarla rekabet edebilmek ve değişen dünya düzenine ayak uydurabilmek için ülkeler yeterli rekabet gücüne sahip olmalıdır. Ülkelerin yoğun rekabet ortamında istikrarlı biçimde rekabet gücünü artırması ve sürdürülebilir kalkınma süreci yönetebilmesinin en önemli adımlarından birini inovasyon yeteneği oluşturmaktadır. Diğer ülkelerde olduğu gibi ülkemiz de küresel rekabet gücü elde edebilmek amacıyla yalnızca sosyal, siyasal, coğrafi ve ekonomik yetkinliklerin yeterli sayılamayacağının farkındadır. Bu gerçekliği göz önünde bulundurarak teknolojik avantaj elde etmek ve serbest piyasanın yoğun rekabet savaşında en önlerde yer alabilmek için inovasyon gerçekleştirmektedir. İnovasyon gerçekleştirerek hem teknolojik açıdan fırsatlar elde etme hem de ekonomik açıdan güç elde etme amaçlanmaktadır. Gerçekleştirilen bu çalışma, Türkiye’nin sürdürülebilir kalkınma amaçları çerçevesinde yürüttüğü inovasyon politikasını belirli sektörler kapsamında karşılaştırmalar yaparak incelemektedir. Cumhurbaşkanlığı Strateji ve Bütçe Başkanlığı liderliğinde oluşturulan 11. Kalkınma Planı’nda (2019-2023) yer alan kalkınma hedefleri ve bu doğrultuda izlenen politikalar incelenerek, belirlenen bu hedeflere ne derece erişildiği değerlendirilmiştir. Gelişmekte olan ülkelerden biri olarak, Küresel İnovasyon Endeksi’nde hızlıca ilerleyen en belirgin ülke olduğu için Türkiye çalışma kapsamında yer almaktadır. Bu amaç doğrultusunda, ülkemizde yürütülen inovasyon çalışmalarının Küresel İnovasyon Endeksi’nden (GII) faydalanılarak analizi gerçekleştirilmiştir. Çalışmanın literatüre katkıları, Türkiye’nin Küresel İnovasyon Endeksi’ndeki pozisyonunun yıllar boyunca nasıl değiştiğini vurgulaması ve özellikle de inovasyon ile sürdürülebilir kalkınmanın 11. Kalkınma planında ilk defa yer almasından dolayı detaylıca ele alınması olarak sıralanabilir.
Dissecting cellulitis of the scalp (Hoffman’s disease): a clinical case
Authors: Krasnova N.V. , Gimalieva G.G. , Koltsova I.V.
Published: February 2025

Dissecting cellulitis of the scalp (Hoffman’s disease) is a rare disease characterized by chronic inflammation of the follicles, formation of papules, pustules and keloids on the skin leading to scarring alopecia. Etiology of this disease is not fully studied, but it is believed that this condition is associated with the hair follicles obstruction. Dissecting cellulitis of the scalp (Hoffman’s disease) predominantly affects young men. Chronicity and severity of the disease significantly influence the quality of life of patients, causing pronounced aesthetic discomfort. Pathogenesis and clinical picture have a number of similarities with diseases of the scalp. Therefore, histological confirmation of the diagnosis is required. Study of rare clinical cases in the field of dermatology plays an important role in increasing the level of professional competence and enhancing the practical experience of doctors. The clinical case of Hoffman’s disease, its manifestations, approach to diagnosis and therapy are considered. Modern treatment methods include antibiotics, isotretinoin and surgical interventions, genetically engineered biological drugs, but their effectiveness in treating this disease is often limited. The lack of algorithms, tactics, as well as the availability of various methods of the disease’s treatment leave this question open.
Clinical and anamnestic features of rosacea in women in perimenopausal period
Authors: Kovaleva Yu.S. , Nikolaeva M.G. , Reshetova S.V.
Published: February 2025

Background. Perimenopausasal transition in women is characterized by vasomotor and psychoemotional symptoms, sleep disturbance, development of genitourinary menopausal syndrome, dermatological problems that together worsen the quality of life and determine the medico-social significance of the problem. Rosacea, which is based on vascular pathomorphological and pathophysiological changes occurring in presence of already existing somatic diseases, is one of the frequent dermatoses of the perimenopausal period. Objective — assessment of clinical and anamnestic characteristics of women in perimenopausal period, suffering from rosacea. Material and methods. The study involved 97 patients with rosacea, mean age 50.0±2.7 years. The control group included 60 women, mean age 49.0±2.5 years. Within the study group, an additional division into 2 subgroups (pre- and postmenopausal period) was carried out. All women of the study and control groups were examined by physical examination, obstetric-gynecological, somatic and thrombotic history was studied. Results. Patients with rosacea statistically significantly more often had stage I—II arterial hypertension (OR 2.51, p=0.0377) and history of chronic diseases of the appendages (OR 4.89, p=0.0405) regardless of the stage of perimenopausal transition. Subjects in the postmenopausal period predominantly had moderate and severe papulopustular subtype of rosacea (p=0.0516), while patients with preserved menstrual function were more likely to have erythematotelangiectatic subtype (p=0.0516) with a predominance of mild severity of the disease’s course (p=0.0506). Conclusion. The obtained data show different clinical course and severity of rosacea depending on the perimenopausal period and indicate the need for a comprehensive study of medical history for further patients monitoring together with allied specialists to achieve optimal therapeutic outcome.
Randomized study of efficacy and safety of combined application of hyaluronic acid-based dermal implants, IPL technology and non-ablative laser fractional resurfacing for age-related changes correction
Authors: Sapon A.M. , Gutop E.O. , Akhmedbaeva I.A. , Korzun Yu.L. , Rumak A.S.
Published: February 2025

Application of multifunctional apparatuses and combined skin quality improvement protocols is becoming increasingly popular. Objective. To determine the efficacy and safety of combined application of hyaluronic acid-based dermal implants, narrow-band pulsed light technology and non-ablative fractional photothermolysis. Material and methods. The study involved 25 healthy volunteers aged 35—65 years. Randomization method was used to select 5 groups of 5 participants. In group I, a comprehensive correction was performed (skin preparation with biorevitalizants, 3 hardware procedures using phototherapy, laser non-ablative remodeling and volumetric modeling with hyaluronic acid-based drugs), in group II — 3 hardware procedures with the use of phototherapy and laser non-ablative remodeling, in group III — comprehensive correction (skin preparation by biorevitalizants, 3 hardware procedures using phototherapy and laser non-ablative remodeling), in group IV — 3 hardware procedures with the application of phototherapy, in group V — only volumetric correction. Results. Improvement of skin color and smoothing of small wrinkles have been observed in all groups, but the most significant reduction of erythema has been noted in groups I and III. Thus, the skin redness has reduced after the biorevitalization procedure before the start of the hardware correction. The depth of wrinkles and folds has expectedly decreased in groups I and V, as well as to a lesser extent in group III. No significant change in skin color has been demonstrated in patients of group V. Patients in all groups have reported improvement on the grading scales as well as high satisfaction level. Conclusion. The study confirms the safety and efficacy of combining biorevitalizants, hardware technologies and hyaluronic acid-based fillers in the comprehensive protocols for rejuvenation and improvement of skin quality. The analysis of the obtained results shows a more pronounced reduction in pigmentation, erythema and wrinkles in patients who underwent complex correction.
"The pen is a powerful weapon; it can make you change": Exploring empowerment through reflective writing in adolescents
Authors: Wegner Lisa , Struthers Patricia , Mohamed Suraya
Published: February 2025

Introduction: Adolescent programmes have been criticised for implementing activities but not allowing opportunities for reflection. One way that reflection can be facilitated is through writing. This paper describes the use of reflective writing with adolescents as part of a health promoting schools project in Cape Town, South Africa.Method: The project included an annual leadership camp for adolescent learners. A descriptive, qualitative study was conducted to describe how the learners responded to writing as a means to express their feelings about, and experiences of, the camp. Thirty learners participated in two writing sessions resulting in 53 written reflections that were analysed thematically.Findings: Three themes emerged: (1) Reflections on self; (2) Reflections on self in relation to others; and (3) Reflections on writing. Participants reflected on connecting with complex, positive and negative feelings, and felt that reflective writing had enabled them to express themselves with courage and honesty, connect with themselves, identify weaknesses and let go of negative emotions and feelings. Furthermore, writing was perceived as being non-judgmental, providing a sense of relief and release, and evoking emotions.Â Conclusion: Reflective writing enabled the participants to acknowledge personal changes and development, and provided insight into their feelings and experiences. This study shows the value of reflective writing for use by health professionals such as occupational therapists, as a tool for empowerment in the pursuit of health and wellbeing. Â Key words: adolescents, empowerment, health promoting schools, reflective writing
Pre-Presbyopia, Asthenopia, and Refractive Errors are Associated among Handcrafting Workers in Lucknow
Authors: Ragni Kumari
Published: February 2025

Purpose: To determine the effect of handcrafting on different types of refractive errors and to verify whether there is an association between asthenopia and presbyopia with this labor. The study design was a case series study (stratified random sampling study). Study conducted in Lucknow district of Uttar Pradesh from May 2022 to June 2023.
Material and Methods: For this study, 4800 subjects aged 16-35 years were selected. Visual acuity, retinoscopy, flashlight examination, ophthalmoscopy, and pencil push-up test were performed on each subject. A questionnaire was also completed with the information given by the subjects after informed consent.
Results: For this study, a total of 4800 patients, 35% were males and 65% females, aged 16 to 35 years, were selected to check for eye strain, headache, decrease in near vision before the age of 35 years, and whether or not any type of refractive error was present in the sample. 70% of patients had near visual acuity of N6, 17% had N8, and 13% were between N10-N12. In this study, there were only 13% emmetropes, 42% myopes, 28% hyperopes and 17% astigmatism. Of the N6 group, 57.1% suffered from ocular complaints and 62.8% from headaches. In the N8 group, 88.2% had ocular strain and 94.1% had headache. In group N10-N12, 69.2% had ocular strain and 92.3% had headache.
Conclusion: There is a strong association between refractive errors and pre-presbyopia, but a strong association with asthenopia in workers in handcrafting occupations.
Preparation of indexing primer stock racks v1
Authors: Nagel Sarah , Meyer Matthias
Published: February 2025

Protocol for the preparation of tube racks in 96 SBS format containing indexing primers at a concentration of 100 µM. These stocks are needed by the Ancient DNA Core Unit of the MPI-EVA to create indexing primer aliquot plates for the automated set-up of indexing PCRs after library preparation.
A Workflow Protocol to Apply Laser-Capture Microdissection (LCM) for Isolating Zone-Specific Cell Populations from Four Zones of Mandibular Condylar Cartilage (MCC) Individually and Preparing the Resultant Minute LCM Samples for Subsequent Downstream Analy v1
Authors: M Basudan Aisha , Basudan Aisha
Published: February 2025

Mandibular condylar cartilage (MCC) is a multizonal heterogeneous fibrocartilage consisting of fibrous (FZ), proliferative(PZ), mature (MZ), and hypertrophic (HZ) zones. The protocol described below is an optimized laser-capture micro dissection (LCM) protocol that aims to describe the procedures of isolating four homogenous cell populations from each of the four mandibular condylar cartilage (MCC) zones individually. It also aims to improve the quality of RNA recovered from zonal-based minute LCM samples in preparation for the subsequent downstream analysis. The protocol illustrates the optimized procedures in three stages: before-LCM stage where stained/unstained frozen tissue sections are prepared for the next LCM procedure. This includes specimen freezing and cryosectioning, followed by staining and dehydration of the frozen tissue sections. LCM stage using IR laser (Arcturus PixCell® lle Laser Capture Microdissection System, CA,USA). after-LCM stage where total RNA molecules are retrieved from the LCM samples. This includes RNA extraction, RNA isolation, and evaluation of LCM-RNA integrity. We also described how to prepare the LCM-RNA samples for subsequent molecular analyses (e.g. Microarray Analysis) in terms of linear amplification of LCM-RNA samples, labeling and fragmentation of amplified aRNA, and preparation of the hybridization mix for microarray analysis.
Mujeres Migradas y Autocuidado Comunitario en España y Argentina
Authors: Cuadra-Durán Cristina , Agrela-Romero Belén , Rosas Carolina
Published: February 2025

Investigaciones precedentes en materia de género y migración evidencian que los cuidados comunitarios son prácticas sociales que despliegan las mujeres en los distintos momentos de sus procesos migratorios. Sin embargo, aún son incipientes los análisis que, desde una perspectiva comparada, prestan atención a las acciones cotidianas de autocuidados que las mujeres migradas realizan entre sí para sostenerse material y afectivamente. Por ello, este artículo analiza experiencias de autocuidados comunitarios en España y Argentina (2020-2024), dinamizadas y autogestionadas por mujeres migradas de origen latinoamericano. Sirviéndonos de un enfoque metodológico cualitativo y feminista, sustentado por las técnicas de observación sistemática y entrevistas en profundidad, se problematiza sobre las motivaciones y dinámicas de participación que las mujeres desarrollan para resolver sus necesidades y ejercer sus derechos de ciudadanía a través de agrupaciones comunitarias. Los resultados muestran cómo, mediante estrategias intergeneracionales e interseccionales, las mujeres migradas logran enfrentar diferentes formas de violencia y visibilizar el potencial transformador de las agencias que desarrollan en los contextos de destino.
Investigating the Malaysian ESL Classrooms As Dynamic And Multifaceted Communities Of Practice
Authors: Teh David Tchaikovsky Boon Ern
Published: February 2025

Community of practice refers to the communal use and maintenance of shared practices, values, and engagement but discourse on how it transpires in Malaysian English as a second language (ESL) classrooms are limited. This study proposes a novel positioning of teachers as traversal agents operating in various classroom communities of pratice to investigate how teachers profile their learners as a community of ESL learners. Firstly, thirty-three teachers were briefed about the theoretical and practical applications of Community of Practice. They were then observed teaching between three to six lessons, which were planned based on the information gathered from a proposed community of practice survey. The observations and survey findings demonstrated how the positioning of teachers as traversal agents in classroom communities has enhanced their abilities to: (i) identify classroom language use (ii) leverage classroom dynamics to promote better learner engagement. Subsequent interviews and focus groups highlighted the survey’s ability to personalise, differentiate, and localise learning. Future studies can employ statistical measures to model the language teacher’s membership in Malaysian ESL classroom communities and provide robust triangulation of said positionality.
Listening in Good Faith: Cosmopolitan Intimacy and Audio Journalism
Authors: Lacey Kate
Published: February 2025

This article interrogates the privileging of intimacy in contemporary discussions of media in general and audio journalism in particular (within a broadly Anglo-American frame). It posits that the prominence of the term in relation to podcasting specifically, together with the communicative practices it purports to describe, has become ideological. The article begins by exploring how the intimate address of radio and podcasting has been variously invoked and celebrated in public and academic discourse across a century of spoken word media. This historical overview provides a context and counterpoint to the ways in which intimacy is invoked in contemporary discourses and the contradictions encapsulated by the notion of an “intimate public sphere” (Berlant, 1998). It highlights how the language of intimacy in the public realm—with all its positive connotations, including in relation to building trust—can be appropriated or transformed under the logics of communicative capitalism (Dean, 2005) to disguise unequal power relations, restrict communication across difference, and feed into a culture of atomised individualism. The article turns instead to a cosmopolitan ethics of “proper distance” (Silverstone, 2004) combined with a feminist ethics of care as a way to negotiate the balance between intimacy and trust for the listening public.
Datacasting: TikTok’s Algorithmic Flow as Televisual Experience
Authors: Firth Ellenrose , Marinelli Alberto
Published: February 2025

Recommendation algorithms have acquired a central role in the suggestion of content within both subscription video on demand (SVOD) and advertising-based video on demand (AVOD) services and media-sharing platforms. In this article, we suggest the introduction of the datacasting paradigm, which takes into account the increasing relevance algorithms have in selection processes on audiovisual platforms. We use TikTok as a case study as it is an entirely algorithmic platform, and therefore embodies the heart of our discussion, and analyse how the algorithmic flow within the platform influences user experience, the impact it has on the enjoyment of content, and whether the platform can be considered televisual. We have opted to frame TikTok within debates on flow, as we believe that is what is at the core of the platform experience. Through the analysis of in-depth interviews, we extracted two main categories of responses: TV on TikTok and TikTok as TV. The former includes all responses related to the consumption of traditional televisual material on the platform, while the latter looks at all potential connections between the platform and television viewing habits.
Интимальная саркома. Описание клинических случаев
Authors: Кудайбергенова А. Г. , Туркевич Е. А. , Горбань Н. А.
Published: February 2025

Интимальная саркома – очень редкая злокачественная мезенхимальная опухоль, возникающая в крупных кровеносных сосудах системного и легочного кровообращения, а также в сердце. Прогноз при интимальной саркоме обычно неблагоприятный, причем на него оказывает большое влияние выбор тактики лечения в пользу хирургического вмешательства. Статья представляет собой анализ двух клинических случаев интимальной саркомы сердца, обзор литературы, обсуждение возможных ошибок в диагностике этого редкого заболевания.
The influence of attitudes and social norms on seeking psychological help among Russian adults
Authors: Tkach Sergey , Odinokova Veronika A. , Burdina Olga I.
Published: February 2025

BACKGROUND: In Russia, the rising prevalence of psychological distress potentially leads to reduced work capacity, a lower quality of life, and an increased risk of suicidal behavior. The utilization of psychological services remains low, necessitating further research to enhance the effectiveness of mental health disorder prevention and suicide prevention strategies.
AIM: To assess the influence of attitudes and social norms on seeking psychological help among Russian adults.
MATERIALS AND METHODS: The study included residents of Saint Petersburg aged 18 and older and was conducted through a computer-assisted telephone interview (CATI). The survey focused on experiences with seeking psychological help and attitudes toward it. The sample, comprising 1,200 participants, was representative of gender and age distribution, in accordance with St. Petersburg demographic data provided by Rosstat. The survey was conducted in July 2023. Factors influencing help-seeking behavior were analyzed using binary logistic regression.
RESULTS: Key factors influencing the decision to seek psychological help were identified. These included gender, age, and social norms, which manifested in the perceived prevalence of psychological help-seeking among acquaintances and expectations of social approval. Additionally, attitudes toward psychological help played a significant role, particularly perceptions that such assistance is only necessary for individuals with mental illnesses or those of high financial status.
CONCLUSION: The findings indicate a need to increase psychological help-seeking rates, considering the specific needs of different social groups, particularly men and older adults. This underscores the importance of destigmatization efforts and informational campaigns aimed at raising awareness about the accessibility and effectiveness of psychological services.
Influencia del turismo en la identidad social y sentido de pertenencia:
Authors: Moo Canul María de Lourdes , Segrado Pavon Romano Gino , López Contreras Cruz
Published: February 2025

El turismo transforma comunidades, afecta la identidad social y el sentido de pertenencia, que facilita los conflictos sociales, la gentrificación y la dilución del capital social, especialmente en aquellos destinos con escasas oportunidades de desarrollo económico. Los atractivos turísticos pueden actuar como catalizadores de oportunidades para generar beneficios locales y fortalecer la identidad comunitaria, aunque el mercado prioriza los aspectos económicos estimulando el individualismo, la diferenciación y recomposición comunitaria. El propósito de la investigación fue analizar las variables vinculadas al sentido de pertenencia en comunidades turísticas. Se realizó una revisión exhaustiva de la literatura guiada por el marco SALSA. Para garantizar la calidad y relevancia de la información, se seleccionaron revistas científicas considerando el índice de SCImago Journal Rank ≥ 2.0 entre el 2018 y 2022. Se analizaron 63 artículos científicos que cumplieron los criterios de inclusión y se identificaron variables por medio del análisis temático. Como resultados, los estudios han abordado principalmente el sentido de pertenencia en destinos turísticos desde las perspectivas de los residentes; las variables más frecuentes son 1) metaestereotipos, 2) percepción socioeconómica, 3) bienestar local, 4) desarraigo, 4) mezcla emocional, 5) empoderamiento, 6) eventos, 7) responsabilidad patrimonial y 8) significación social. Los resultados servirán para el desarrollo de normativas públicas para gestionar adecuadamente los conflictos en destinos turísticos, relacionados a la identidad comunitaria.
Current concepts in the management of infected non-union of the femur: internal versus external fixation
Authors: Kaul R. , Dubey R. R. , Agrawal R. , Pande A.
Published: February 2025

Introduction The management of infected non-unions continues to be a herculean task for the orthopaedic surgeon due to the emergence of microbial resistance, failure of fixation, frequent re-fractures and resurgence of previously treated infection.

The aim of the paper was to structure the approach to the management of patients with infected femoral non‑union based on the literature review and surgeons’ experience.

Material and methods A detailed literature review, including current updates on the management of fracture‑resistant infections (FRI) and non-union of the femur was conducted. Search words and phrases used for navigation in the international medical literature platforms were: osteomyelitis, non-union, diagnostic solutions, local antibiotics, biomechanical stability.

Results and Discussion The principles of surgical management of infected non-union of the femur remain the  same: (a) adequate soft tissue sampling; (b) thorough debridement; (c) fracture stabilization; (d) dead space and defect management; (e) delivery of local antibiotics and (f) soft tissue coverage. The goal of surgery is to get rid of infection. There is no place for empirical treatment of suspected infection. Therapy should be initiated based upon microbial cultures of deep tissue specimens. While selecting the type of hardware for non-union of the femur, one often encounters a dilemma concerning the most appropriate surgical tool for stabilization. Internal fixation with bone grafting would depend on the size of the gap; commonly defects < 6 cm are treated with this modality. External fixation becomes indispensable in certain scenarios such as poor local skin and soft tissue conditions, associated limb length discrepancy > 2 cm, large defect gaps ≥ 6 cm, concomitant deformity, small fragments or osteopenic bone.

Conclusion Based on this review of current concepts, the authors conclude that there is no ideal or universal approach for management of infected non-union of the femur, and the approach may vary depending on the technical expertise available and the institutional practices. Irrespective of the modality used, the golden rules of fixation remain the same, alignment, preservation of biology, contact of fragments, stability and early restoration of function.
Impact of personalized alignment technique on implant components position in total knee arthroplasty
Authors: Kuzin V. V. , Kuzin A. V. , Germanov A. V. , Shpak M. A.
Published: February 2025

Introduction Due to substantial rates of dissatisfaction in patients with mechanical alignment in total knee replacement, surgeons began searching for alternative techniques to improve functional outcome. In the recent decade, kinematic alignment that is not based on the mechanical axis of the femur has become the most popular alternative to mechanical alignment. Kinematic alignment technique development has led to creation of a personalized alignment technique.

Purpose To compare postoperative implant positions in full-length standing lower-leg radiographs between kinematic alignment and mechanical alignment groups of patients.

Materials and methods A prospective, single-center, randomized, controlled study was performed in 139 patients with grade 3–4 knee osteoarthritis (Kellgren – Lawrence). We collected data from 76 cases of mechanical alignment (66 women and 10 men) and 83 cases of personalized alignment group (60 women and 23 men). There were no patients with significant post-traumatic or other deformities of the lower limb which can alter the results in the study. All measurements were done on digital full-length standing X-rays of the lower legs with special MediCAD software.

Results The positions of the implant components in mechanical and personalized alignments did not differ significantly in many parameters after operations, despite the fact that the alignment was based on completely different principles. There were no differences between the average values of the angles after operations with mechanical and anatomical axes of the femur in both study groups (the difference was 0.1° at p = 0.595). The only difference in the groups was the position of the tibial component in relation to the horizontal surface in the standing position: in personalized alignment, the angle was 0.9°, and in mechanical alignment it was 2.4° valgus (p < 0.001).

Discussion The absence of significant difference in the postoperative leg alignment and implant position except in the joint line orientation between the groups demonstrates possibility to achieve good leg alignment with both techniques. In the personalized alignment group, the joint line orientation in the coronal plane was found nearly parallel to the ground which can result in a more balanced weight distribution compared to mechanical alignment.

Conclusion In patients who receive total knee replacement with the personalized technique, the postoperative lower limb alignment was found within the safe boundaries of 3° from the mechanical axis while the joint line orientation in the coronal plane was significantly closer to be parallel with the ground compared with mechanical alignment group.