bluuebunny/crossref_metadata_2025 huggingface dataset:
Profiles of Genomic Instability in High-Grade Serous Ovarian Cancer Predict Treatment Outcome
Authors: Wang Zhigang C. , Birkbak Nicolai Juul , Culhane Aedín C. , Drapkin Ronny , Fatima Aquila , Tian Ruiyang , Schwede Matthew , Alsop Kathryn , Daniels Kathryn E. , Piao Huiying , Liu Joyce , Etemadmoghadam Dariush , Miron Alexander , Salvesen Helga B. , Mitchell Gillian , DeFazio Anna , Quackenbush John , Berkowitz Ross S. , Iglehart J. Dirk , Bowtell David D.L. ,   for the Australian Ovarian Cancer Study Group, Matulonis Ursula A.
Published: August 2012

Purpose: High-grade serous cancer (HGSC) is the most common cancer of the ovary and is characterized by chromosomal instability. Defects in homologous recombination repair (HRR) are associated with genomic instability in HGSC, and are exploited by therapy targeting DNA repair. Defective HRR causes uniparental deletions and loss of heterozygosity (LOH). Our purpose is to profile LOH in HGSC and correlate our findings to clinical outcome, and compare HGSC and high-grade breast cancers.

Experimental Design: We examined LOH and copy number changes using single nucleotide polymorphism array data from three HGSC cohorts and compared results to a cohort of high-grade breast cancers. The LOH profiles in HGSC were matched to chemotherapy resistance and progression-free survival (PFS).

Results: LOH-based clustering divided HGSC into two clusters. The major group displayed extensive LOH and was further divided into two subgroups. The second group contained remarkably less LOH. BRCA1 promoter methylation was associated with the major group. LOH clusters were reproducible when validated in two independent HGSC datasets. LOH burden in the major cluster of HGSC was similar to triple-negative, and distinct from other high-grade breast cancers. Our analysis revealed an LOH cluster with lower treatment resistance and a significant correlation between LOH burden and PFS.

Conclusions: Separating HGSC by LOH-based clustering produces remarkably stable subgroups in three different cohorts. Patients in the various LOH clusters differed with respect to chemotherapy resistance, and the extent of LOH correlated with PFS. LOH burden may indicate vulnerability to treatment targeting DNA repair, such as PARP1 inhibitors. Clin Cancer Res; 18(20); 5806–15. ©2012 AACR.
The Promise of Patient-Derived Xenografts: The Best Laid Plans of Mice and Men
Authors: Kopetz Scott , Lemos Robert , Powis Garth
Published: August 2012

Compared with xenografts from previously established cell lines, patient-derived xenografts may more faithfully recapitulate the molecular diversity, cellular heterogeneity, and histology seen in patient tumors, although other limitations of murine models remain. The ability of these models to inform clinical development and answer mechanistic questions will determine their ultimate use. Clin Cancer Res; 18(19); 5160–2. ©2012 AACR.
The Power of Negative Thinking: Which Cells Limit Tumor Immunity?
Authors: Tang Siuwah , Lotze Michael T.
Published: August 2012

Why human tumors grow infiltrated by specific antitumor T cells has been a mystery attributed to negative factors released directly by the tumor or indirectly through immune intermediaries. The frequency and phenotype of myeloid-derived suppressor cells in the peripheral blood of melanoma patients and healthy donors are surprisingly similar. Clin Cancer Res; 18(19); 5157–9. ©2012 AACR.
Sorafenib-Induced Hepatocellular Carcinoma Cell Death Depends on Reactive Oxygen Species ProductionIn VitroandIn Vivo
Authors: Coriat Romain , Nicco Carole , Chéreau Christiane , Mir Olivier , Alexandre Jérôme , Ropert Stanislas , Weill Bernard , Chaussade Stanislas , Goldwasser François , Batteux Frédéric
Published: August 2012

Sorafenib is presently the only effective therapy in advanced hepatocellular carcinoma (HCC). Because most anticancer drugs act, at least in part, through the generation of reactive oxygen species, we investigated whether sorafenib can induce an oxidative stress. The effects of sorafenib on intracellular ROS production and cell death were assessed in vitro in human (HepG2) and murine (Hepa 1.6) HCC cell lines and human endothelial cells (HUVEC) as controls. In addition, 26 sera from HCC patients treated by sorafenib were analyzed for serum levels of advanced oxidation protein products (AOPP). Sorafenib significantly and dose-dependently enhanced in vitro ROS production by HCC cells. The SOD mimic MnTBAP decreased sorafenib-induced lysis of HepG2 cells by 20% and of Hepa 1.6 cells by 75% compared with HCC cells treated with 5 mg/L sorafenib alone. MnTBAP significantly enhanced by 25% tumor growth in mice treated by sorafenib. On the other hand, serum levels of AOPP were higher in HCC patients treated by sorafenib than in sera collected before treatment (P < 0.001). An increase in serum AOPP concentration ≥0.2 μmol/L chloramine T equivalent after 15 days of treatment is a predictive factor for sorafenib response with higher progression free survival (P < 0.05) and overall survival rates (P < 0.05). As a conclusion, sorafenib dose-dependently induces the generation of ROS in tumor cells in vitro and in vivo. The sera of Sorafenib-treated HCC patients contain increased AOPP levels that are correlated with the clinical effectiveness of sorafenib and can be used as a marker of effectiveness of the drug. Mol Cancer Ther; 11(10); 2284–93. ©2012 AACR.
PI3K Inhibition Impairs BRCA1/2 Expression and Sensitizes BRCA-Proficient Triple-Negative Breast Cancer to PARP Inhibition
Authors: Ibrahim Yasir H. , García-García Celina , Serra Violeta , He Lei , Torres-Lockhart Kristine , Prat Aleix , Anton Pilar , Cozar Patricia , Guzmán Marta , Grueso Judit , Rodríguez Olga , Calvo Maria Teresa , Aura Claudia , Díez Orland , Rubio Isabel T. , Pérez José , Rodón Jordi , Cortés Javier , Ellisen Leif W. , Scaltriti Maurizio , Baselga José
Published: August 2012

PARP inhibitors are active in tumors with defects in DNA homologous recombination (HR) due to BRCA1/2 mutations. The phosphoinositide 3-kinase (PI3K) signaling pathway preserves HR steady state. We hypothesized that in BRCA-proficient triple-negative breast cancer (TNBC), PI3K inhibition would result in HR impairment and subsequent sensitization to PARP inhibitors. We show in TNBC cells that PI3K inhibition leads to DNA damage, downregulation of BRCA1/2, gain in poly-ADP-ribosylation, and subsequent sensitization to PARP inhibition. In TNBC patient–derived primary tumor xenografts, dual PI3K and PARP inhibition with BKM120 and olaparib reduced the growth of tumors displaying BRCA1/2 downregulation following PI3K inhibition. PI3K-mediated BRCA downregulation was accompanied by extracellular signal–regulated kinase (ERK) phosphorylation. Overexpression of an active form of MEK1 resulted in ERK activation and downregulation of BRCA1, whereas the MEK inhibitor AZD6244 increased BRCA1/2 expression and reversed the effects of MEK1. We subsequently identified that the ETS1 transcription factor was involved in the ERK-dependent BRCA1/2 downregulation and that knockdown of ETS1 led to increased BRCA1/2 expression, limiting the sensitivity to combined BKM120 and olaparib in 3-dimensional culture.

Significance: Treatment options are limited for patients with TNBCs. PARP inhibitors have clinical activity restricted to a small subgroup of patients with BRCA mutations. Here, we show that PI3K blockade results in HR impairment and sensitization to PARP inhibition in TNBCs without BRCA mutations, providing a rationale to combine PI3K and PARP inhibitors in this indication. Our findings could greatly expand the number of patients with breast cancer that would benefit from therapy with PARP inhibitors. On the basis of our findings, a clinical trial with BKM120 and olaparib is being initiated in patients with TNBCs. Cancer Discov; 2(11); 1036–47. ©2012 AACR.

Read the Commentary on this article by Rehman et al., p. 982.

This article is highlighted in the In This Issue feature, p. 961
Modeling Supravalvular Aortic Stenosis Syndrome With Human Induced Pluripotent Stem Cells
Authors: Ge Xin , Ren Yongming , Bartulos Oscar , Lee Min Young , Yue Zhichao , Kim Kun-Yong , Li Wei , Amos Peter J. , Bozkulak Esra Cagavi , Iyer Amulya , Zheng Wei , Zhao Hongyu , Martin Kathleen A. , Kotton Darrell N. , Tellides George , Park In-Hyun , Yue Lixia , Qyang Yibing
Published: August 2012

Background—

Supravalvular aortic stenosis (SVAS) is caused by mutations in the elastin (
ELN
) gene and is characterized by abnormal proliferation of vascular smooth muscle cells (SMCs) that can lead to narrowing or blockage of the ascending aorta and other arterial vessels. Having patient-specific SMCs available may facilitate the study of disease mechanisms and development of novel therapeutic interventions.

Methods and Results—

Here, we report the development of a human induced pluripotent stem cell (iPSC) line from a patient with SVAS caused by the premature termination in exon 10 of the
ELN
gene resulting from an exon 9 four-nucleotide insertion. We showed that SVAS iPSC-derived SMCs (iPSC-SMCs) had significantly fewer organized networks of smooth muscle α-actin filament bundles, a hallmark of mature contractile SMCs, compared with control iPSC-SMCs. The addition of elastin recombinant protein or enhancement of small GTPase RhoA signaling was able to rescue the formation of smooth muscle α-actin filament bundles in SVAS iPSC-SMCs. Cell counts and BrdU analysis revealed a significantly higher proliferation rate in SVAS iPSC-SMCs than control iPSC-SMCs. Furthermore, SVAS iPSC-SMCs migrated at a markedly higher rate to the chemotactic agent platelet-derived growth factor compared with the control iPSC-SMCs. We also provided evidence that elevated activity of extracellular signal-regulated kinase 1/2 is required for hyperproliferation of SVAS iPSC-SMCs. The phenotype was confirmed in iPSC-SMCs generated from a patient with deletion of elastin owing to Williams-Beuren syndrome.

Conclusions—

SVAS iPSC-SMCs recapitulate key pathological features of patients with SVAS and may provide a promising strategy to study disease mechanisms and to develop novel therapies.
Seedability of Winter Orographic Clouds
Authors: Hill Geoffrey E.
Published: August 2012

This article is a review of work on the subject of seedability of winter orographic clouds for increasing precipitation. Various aspects of seedability are examined in the review, including definitions, distribution of supercooled liquid water, related meteorological factors, relationship of supercooled liquid water to storm stage, factors governing seedability, and the use of seeding criteria.

Of particular interest is the conclusion that seedability is greatest when supercooled liquid water concentrations are large and at the same time precipitation rates are small. Such a combination of conditions is favored if the cloud-top temperature is warmer than a limiting value and as the cross-barrier wind speed at mountaintop levels increases.

It is also suggested that cloud seeding is best initiated in accordance with direct measurements of supercooled liquid water, precipitation, and cross-barrier wind speed. However, in forecasting these conditions or in continuation of seeding previously initiated, the cloud-top temperature and cross-barrier wind speed are the most useful quantities.
Meteorology of the Southern Hemisphere
Authors: Karoly David J. , Vincent Dayton G.
Published: August 2012

No Abstract available.
Leeside Boundary Layer Confluence and Afternoon Thunderstorms over Mayaguez, Puerto Rico
Authors: Jury Mark R. , Chiao Sen
Published: August 2012

The midsummer boundary layer (BL) circulation and afternoon thunderstorm convection on the lee side of Puerto Rico is studied using observations and high-resolution models. Satellite infrared data help to identify cases on 5 and 14 June 2010 when midday surface temperatures show a 2°C gradient between land and sea and afternoon cloud-top temperatures <−60°C. Acoustic sounder profiles are analyzed for climatology, wind shear, turbulence, and diurnal cycles in the 40–300-m layer. Weather Research and Forecasting (WRF) model simulations indicate that sea-breeze flow is entrained into convective cells near Mayaguez, Puerto Rico. The simulated BL wind shear is too weak (0.5 × 10−2 s−1) in comparison with the acoustic sounder (2 × 10−2 s−1). Model 900-hPa winds are southeasterly and spread simulated convection too far north in comparison with radar. The pattern of near-surface winds in the island wake triggers afternoon thunderstorms near Mayaguez. A feature of the confluent circulation around Puerto Rico is opposing shear zones on the leeward corners of the island and a sea breeze of 5 m s−1 over the west coast during midday.
Contributions of Lake-Effect Periods to the Cool-Season Hydroclimate of the Great Salt Lake Basin
Authors: Yeager Kristen N. , Steenburgh W. James , Alcott Trevor I.
Published: August 2012

Although smaller lakes are known to produce lake-effect precipitation, their influence on the precipitation climatology of lake-effect regions remains poorly documented. This study examines the contribution of lake-effect periods (LEPs) to the 1998–2009 cool-season (16 September–15 May) hydroclimate in the region surrounding the Great Salt Lake, a meso-β-scale hypersaline lake in northern Utah. LEPs are identified subjectively from radar imagery, with precipitation (snow water equivalent) quantified through the disaggregation of daily (i.e., 24 h) Cooperative Observer Program (COOP) and Snowpack Telemetry (SNOTEL) observations using radar-derived precipitation estimates. An evaluation at valley and mountain stations with reliable hourly precipitation gauge observations demonstrates that the disaggregation method works well for estimating precipitation during LEPs. During the study period, LEPs account for up to 8.4% of the total cool-season precipitation in the Great Salt Lake basin, with the largest contribution to the south and east of the Great Salt Lake. The mean monthly distribution of LEP precipitation is bimodal, with a primary maximum from October to November and a secondary maximum from March to April. LEP precipitation is highly variable between cool seasons and is strongly influenced by a small number of intense events. For example, at a lowland (mountain) station in the lake-effect-precipitation belt southeast of the Great Salt Lake, just 12 (13) events produce 50% of the LEP precipitation. Although these results suggest that LEPs contribute modestly to the hydroclimate of the Great Salt Lake basin, infrequent but intense events have a profound impact during some cool seasons.
Ideas Versus Resources
Authors: Appel Hilary , Orenstein Mitchell A.
Published: August 2012

This article examines the rapid spread of pension privatization and the flat tax in former communist countries to understand why new policy ideas take hold and to elucidate the role played by material resources in the diffusion of new policy ideas. Unlike previous liberalizing reforms, these second-generation reforms spread without direct or indirect EU pressure. Rather, policy entrepreneurs in both instances succeeded in arguing that these reforms would serve to make former communist economies more competitive in a highly integrated global economy. Yet the policy network advocating pension privatization, centered around the World Bank, commanded far greater resources than the network of right-wing think tanks supporting the flat tax. To what extent did these superior resources matter? This article concludes that resources may accelerate the diffusion of policy ideas and encourage their adoption in larger states, but policy networks armed with ideas can nonetheless spread reforms quickly in competitive environments even in the absence of significant financial resources or membership conditionalities.
Organizational learning in United Nations’ peacekeeping exit strategies
Authors: Hirschmann Gisela
Published: August 2012

This article illustrates how organizational learning can explain the shift in United Nations’ peacekeeping exit strategies from the election-based approach of the 1990s to peacebuilding. Conceptualizing learning as an ideal-type, three-step process, of knowledge acquisition, interpretation and institutionalization, the analysis reveals the impact of new knowledge on institutional change. It demonstrates how knowledge acquisition became systematized within the United Nations’ Secretariat especially after 2000, with the active promotion of boundary-spanning activities. The analysis then shows how a shared understanding of the role of peacebuilding for exit strategies was developed by the organization’s bureaucracy and intergovernmental bodies in the interpretation step. Finally, it highlights how the establishment of the Peacebuilding Commission institutionalized the transition to peacebuilding as the new exit strategy and how new learning capacities were created. By conceiving the interaction between international organizations and their external environment as a dynamic relationship, the analysis confirms the potential of organizational learning theories for explaining institutional change in international relations.
Orthogonalizing Through Residual Centering
Authors: Geldhof G. John , Pornprasertmanit Sunthud , Schoemann Alexander M. , Little Todd D.
Published: August 2012

Residual centering is a useful tool for orthogonalizing variables and latent constructs, yet it is underused in the literature. The purpose of this article is to encourage residual centering’s use by highlighting instances where it can be helpful: modeling higher order latent variable interactions, removing collinearity from latent constructs, creating phantom indicators for multiple group models, and controlling for covariates prior to latent variable analysis. Residual centering is not without its limitations, however, and the authors also discuss caveats to be mindful of when implementing this technique. They discuss the perils of double orthogonalization (i.e., simultaneously orthogonalizing A relative to B and B relative to the original A), the unintended consequences of orthogonalization on model fit, the removal of a mean structure, and the effects of nonnormal data on residual centering.
Applying Bayesian Modeling and Receiver Operating Characteristic Methodologies for Test Utility Analysis
Authors: Wang Qiu , Diemer Matthew A. , Maier Kimberly S.
Published: August 2012

This study integrated Bayesian hierarchical modeling and receiver operating characteristic analysis (BROCA) to evaluate how interest strength (IS) and interest differentiation (ID) predicted low–socioeconomic status (SES) youth’s interest-major congruence (IMC). Using large-scale Kuder Career Search online-assessment data, this study fit three models, the one-level BROCA, the two-level BROCA, and the ordinal Probit BROCA, to examine the moderating effects of gender and race/ethnicity. Both IS and ID displayed race/ethnicity differences in predicting low-SES females’ IMC. Gender difference was found only on IS in predicting low-SES youth’s IMC. Results suggested that low-SES White males and low-SES minority females may need help the most to develop stronger career interests and to differentiate their interests. This study illustrated that BROCA can be a powerful tool for test evaluation and utility analysis in the field because of its capacity of analyzing continuous, nominal, and ordinal data; its graphical nature of result presentation; multiple statistical test options; and its little requirement of Level 2 sample sizes.
Irregularities below the Enamel-Dentin Junction May Predispose for Fissure Caries
Authors: Kühnisch J. , Galler M. , Seitz M. , Stich H. , Lussi A. , Hickel R. , Kunzelmann K.H. , Bücher K.
Published: August 2012

This study investigated the structure of the fissure fundus on occlusal surfaces with respect to the detection of possible irregularities below the enamel-dentin junction (EDJ). Occlusal surfaces were examined by micro-computed tomography (µCT). In total, 203 third molars with clinically sound occlusal fissures or non-cavitated lesions were selected. All specimens were scanned with µCT. Subsequently, each tooth was sectioned, and each slice was investigated by stereomicroscopy. In 7 of 203 molars (3.4%), demarcated radiolucencies below the EDJ were detected by µCT. These defects were obviously of non-carious origin, because the µCT images revealed no gradient of demineralization in the dentin. In all cases, a direct pathway between the oral cavity and the dentin was evident. The comparison of the µCT sites with conventional histological images also revealed defects in the dentin. These results demonstrate that demarcated radiolucencies below the EDJ may not necessarily be caries lesions according to µCT images and may be classified as possible developmental irregularities. To avoid misinterpreting µCT data, dental researchers should carefully consider this condition when analyzing µCT images. The clinical significance of this finding is that these defects may predispose molar teeth to early-onset caries in occlusal pits and fissures.
Effects of Undecylenic Acid Released from Denture Liner on Candida Biofilms
Authors: Gonçalves L.M. , Del Bel Cury A.A. , Sartoratto A. , Garcia Rehder V.L. , Silva W.J.
Published: August 2012

Denture liners (DL) are easily colonized by Candida spp. In an attempt to prevent biofilm colonization, manufacturers have incorporated undecylenic acid (UDA) into DL. In this in vitro study, the effects of UDA released from DL on Candida biofilms were investigated. The concentrations of UDA released from commercial DL were determined by gas chromatography–mass spectrometry (GC-MS). Minimum inhibitory concentration (MIC) and minimum fungistatic concentration (MFC) tests were performed for C. albicans or C. glabrata, with UDA for comparison with the concentrations released from DL. Specimens of DL with (experimental group) and without UDA (control group) were fabricated, and Candida biofilms were developed on DL surfaces. Biofilms were evaluated by cell counts, metabolic activity, structure, and secretion of proteinase or phospholipase. The concentrations of UDA released were within the MIC and MFC ranges. In the presence of UDA, C. albicans biofilms were thinner and had lower numbers of viable and active cells, although no significant enzymatic changes were observed relative to the control group (p > 0.05). In contrast, C. glabrata biofilms exhibited higher cell counts and greater metabolic activity and also increased proteinase activity in the presence of UDA relative to the control group (p < 0.05). Overall, UDA did not prevent Candida biofilm formation.
Fas Ligand Regulates the Immunomodulatory Properties of Dental Pulp Stem Cells
Authors: Zhao Y. , Wang L. , Jin Y. , Shi S.
Published: August 2012

Dental pulp stem cells (DPSCs) possess immunoregulatory properties, but the underlying mechanism is not fully understood. Here we showed that DPSCs were capable of inducing activated T-cell apoptosis in vitro and ameliorating inflammatory-related tissue injuries when systemically infused into a murine colitis model. Mechanistically, DPSC-induced immunoregulation was associated with the expression of Fas ligand (FasL), a transmembrane protein that plays an important role in inducing the Fas apoptotic pathway. Knockdown of FasL expression by siRNA in DPSCs reduced their capacity to induce T-cell apoptosis in vitro and abolished their therapeutic effects in mice with colitis. However, the expression level of FasL did not affect either DPSC proliferation rate or multipotent differentiation potential. In summary, FasL governs the immunoregulatory property of DPSCs in the context of inducing T-cell apoptosis.
Endodontic Release System for Apexification with Calcium Hydroxide Microspheres
Authors: Strom T.A. , Arora A. , Osborn B. , Karim N. , Komabayashi T. , Liu X.
Published: August 2012

The use of calcium hydroxide (CH) as an intracanal medicament for apexification is widespread. However, because of a short residence time in the root canal, the CH must be refreshed frequently, increasing the number of appointments required and leading to patient non-compliance. We hypothesized that a core-/shell-structured CH microsphere system would lead to sustained slow release of calcium and hydroxide ions of CH for long periods of time, eliminating the need for multiple visits for apexification. In this study, calcium hydroxide microspheres (CHMSs) with a core/shell structure were prepared by an emulsion method. The CHMS shell was composed of alginate, which was crosslinked by the Ca2+ released from the CH in the CHMSs. Therefore, this system provides a unique feedback loop that controls the release of ions from the CHMSs. The in vitro experiments from the root canals of extracted human teeth showed that the CHMSs had a sustained, slow release of Ca2+, at a constant rate of approximately 2 to 3% per month from day one to the six-month endpoint of the experiment. After 6 months, 72.1 ± 5.8% of the total CH from the CHMSs remained in the root canals of the teeth, while only 46.9 ± 10.9% and 36.8 ± 7.5% remained from a commercial product (UltraCal®XS) and CH powder alone, respectively (p < 0.01). The pH of all of the formulations (CHMS, UltraCal® XS, and CH powder) in the extracted teeth never rose above 9 during the release period, indicating a buffering effect of the teeth. The core-/shell-structured CHMSs are, therefore, a promising delivery vehicle for the sustained slow release of Ca2+ and OH- in the root canal.
A Simple Method to Control Positive Baseline Trend Within Data Nonoverlap
Authors: Parker Richard I. , Vannest Kimberly J. , Davis John L.
Published: August 2012

Nonoverlap is widely used as a statistical summary of data; however, these analyses rarely correct unwanted positive baseline trend. This article presents and validates the graph rotation for overlap and trend (GROT) technique, a hand calculation method for controlling positive baseline trend within an analysis of data nonoverlap. GROT is validated for controlling positive baseline trend and validated socially by visual analysis agreement. The flexibility and generality of GROT is demonstrated by using it with two alternative slope calculations: White and Haring’s bi-split and Tukey’s tri-split. In addition, GROT is presented as a technique that can be adapted for any non-overlap effect size method; examples here include the original percent of nonoverlapping data and newer nonoverlap of all pairs. examples here include the original percent of nonoverlapping data and newer nonoverlap of all pairs. Caution is urged to control baseline trend only when it is pronounced and reliable. GROT moves the field forward as a robust technique suitable for both visual and statistical analysis.
Becoming Warm Demanders
Authors: Bondy Elizabeth , Ross Dorene D. , Hambacher Elyse , Acosta Melanie
Published: August 2012

In the literature on culturally responsive pedagogy warm demanders are teachers who embrace values and enact practices that are central to their students’ success. Few scholars have examined the experience of novice teachers who attempt to enact this stance. In this study of two first-year, female, European American teachers who attempted to be warm demanders for their predominantly African American elementary school students, the authors answer the question, “How do the teachers think about and enact warm demanding?” The teachers’ contrasting experiences have implications for administrators and teacher educators.
When Context Has Content
Authors: Hammerness Karen , Matsko Kavita Kapadia
Published: August 2012

Reviews of research evaluating the impact of beginning teacher induction suggest that the mixed results may be due to the fact that the programs do not fully address school context. We examine how one induction program for urban teachers explicitly addresses teachers’ specific schools and students to illustrate how context becomes the content for teachers’ learning and work. We argue that the program’s “context-specific” supports may ease transition into the challenging role of urban teacher. In turn, this case suggests ways of addressing features of context that may help new teachers better understand and maintain a commitment to urban teaching.
The Association Between Overinvolved Parenting and Young Adults’ Self-Efficacy, Psychological Entitlement, and Family Communication
Authors: Givertz Michelle , Segrin Chris
Published: August 2012

This study sought to examine the association between parental behavior indicative of overinvolvement and control and young adult child self-identity, namely self-efficacy and psychological entitlement. Participants in this study were 339 parent-young adult child dyads who completed survey measures of family environment, parenting, family communication, and family satisfaction. Young adults also completed measures of self-efficacy and entitlement. Results showed that balanced family adaptability and cohesion, open family communication, and authoritative rather than authoritarian parenting, were positively associated with parents’ and young adults’ family satisfaction. Parental behavior that emphasized control over the child was associated with diminished self-efficacy and exaggerated psychological entitlement in young adult children. The relationship between these two classes of variables was amplified by open parent-child communication.
Going It Alone
Authors: Perlman Bruce J. , Benton J. Edwin
Published: August 2012

To set the tone for the Special Issue, this article focuses on understanding the total impact of the Great Recession on local governments, predicting whether these impacts will be permanent, and providing explanations for the changes that these governments have made and prescriptions of how to address them and whether it constitutes a “New Normal.” This opening article first reviews the articles in the Special Issue that examine various facets of the “New Normal.” To add substance to this context, data from a recent survey of county and cities are presented and provide timely and useful information on these government’s recovery strategies, patterns of behavior, and responses to the their changed situation brought on by the recession. Finally, this article closes with a consideration of the data against the framework and a call for further research while looking at what these strategies imply about research on new governance arrangements for local governments.
Object-Control: A Study of Technologically Dense Knowledge Work
Authors: Rennstam Jens
Published: August 2012

Drawing on the literature on active objects and combining it with an ethnographic study of engineering work, this paper offers an alternative and complementary understanding of the problem of control in knowledge-intensive work. This problem largely concerns the question of how creative processes of knowing are enabled on behalf of the organization. The dominant response to this question revolves around the idea that when work becomes complex, managers attempt to control the norms and identifications of employees, rather than their behaviours. Through the concept of object-control, the idea is introduced that organizational objects participate on behalf of the organization in processes of knowledge control by interpellating organizational members; that is, organizational members are invited to interact with the objects and to creatively develop knowledge in order to solve organizational problems. The study covers ground that the established notions of normative control and identity regulation have neglected, and suggests new ways of advancing the scholarship of organizational control by taking the active participation of organizational objects into account.
A Model Linking Diverse Women’s Child Sexual Abuse History With Sexual Risk Taking
Authors: Watson Laurel B. , Matheny Kenneth B. , Gagné Phill , Brack Greg , Ancis Julie R.
Published: August 2012

The purpose of our study was to examine the role that child sexual abuse may play in body surveillance and sexual risk behaviors among undergraduate women. First, a measured variable path analysis was conducted, which assessed the relations among a history of child sexual abuse, body surveillance, and sexual risk behaviors. Furthermore, body shame, sexual self-efficacy, and alexithymia were examined as intervening variables. Second, a multigroup path analysis was conducted comparing the hypothesized models applied to data from 556 ethnically diverse women. Within the overall model, results revealed that a history of child sexual abuse and body surveillance were not related to one another, but both variables were directly related to sexual risk behaviors. Moreover, body shame mediated the relationship between body surveillance and alexithymia, and alexithymia mediated the relationship between body shame and sexual self-efficacy. Child sexual abuse history was related directly with body shame and alexithymia. Results from the multigroup path analysis revealed that the model was invariant between African American and White women, although one difference emerged: body surveillance significantly predicted alexithymia in White, but not African American, women. Furthermore, White, Asian/Pacific Islander, and Hispanic/Latina women demonstrated more body shame than African American women, and White women endorsed higher levels of sexual self-efficacy than African American and Asian/Pacific Islander women. Counseling interventions that seek to decrease alexithymic symptoms, body surveillance, and body shame, while also increasing sexual self-efficacy, seem especially warranted.
Prescription of Protective Paternalism for Men in Romantic and Work Contexts
Authors: Sarlet Marie , Dumont Muriel , Delacollette Nathalie , Dardenne Benoit
Published: August 2012

Behavioral prescription specifies how people ought to act. Five studies investigated prescription for men of protective paternalism, a particular form of benevolent sexism, depending on contextual and individual factors. In Studies 1 and 2, female participants prescribed for men more protective paternalistic behavior toward women in a romantic than in a work context. In Study 3, male participants prescribed the same level of protective paternalistic behavior as female participants did. Conversely, more gender egalitarianism was prescribed for men in a work than in a romantic context (Studies 1–3). In Study 4, the same protective paternalistic behavior was labeled as intimacy in a romantic context but was identified to the same extent as intimacy and as sexism in a work context. In Study 5, female participants’ benevolent sexist beliefs predicted their prescription of protective paternalistic behavior for men in both contexts. These studies demonstrated that prescription of protective paternalism for men is a complex phenomenon because it depends on contextual as well as individual variables. These findings need to be added to the list of factors explaining how this particular form of sexism is maintained within gender relationships and how it contributes to women’s subordination.
Why Is Benevolent Sexism Appealing?
Authors: Connelly Kathleen , Heesacker Martin
Published: August 2012

Previous research suggests that benevolent sexism is an ideology that perpetuates gender inequality. But despite its negative consequences, benevolent sexism is a prevalent ideology that some even find attractive. To better understand why women and men alike might be motivated to adopt benevolent sexism, the current study tested system justification theory’s prediction that benevolent sexism might have a positive linkage to life satisfaction through increased diffuse system justification, or the sense that the status quo is fair. A structural equation model revealed that benevolent sexism was positively associated with diffuse system justification within a sample of 274 college women and 111 college men. Additionally, benevolent sexism was indirectly associated with life satisfaction for both women and men through diffuse system justification. In contrast, hostile sexism was not related to diffuse system justification or life satisfaction. The results imply that although benevolent sexism perpetuates inequality at the structural level, it might offer some benefits at the personal level. Thus, our findings reinforce the dangerous nature of benevolent sexism and emphasize the need for interventions to reduce its prevalence.
Volunteers Supporting Older People in Formal Care Settings in England
Authors: Hussein Shereen , Manthorpe Jill
Published: August 2012

In the UK context of financial austerity and the promotion of the social responsibility through the concept of the “Big Society,” volunteers are becoming a more important part of the labor workforce. This is particularly so in the long-term care (LTC) sector, where both shortages of staff and demands for support are particularly high. This article investigate the levels and profile of contribution of volunteers in the LTC sector using a large national data set, National Minimum Data Set for Social Care, linked to local area levels of rurality and socio-economic status. The analysis shows that volunteer activity in formal care services varies between sectors and service types, with no strong relationship between local area deprivation, unemployment levels, and levels of volunteering. However, some significant association was found with level of rurality. The contribution of volunteers is most evident in provision of counseling, support, advocacy, and advice.
Responding to Home Maintenance Challenge Scenarios
Authors: Kelly Andrew John , Fausset Cara Bailey , Rogers Wendy , Fisk Arthur D.
Published: August 2012

This study examined potential issues faced by older adults in managing their homes and their proposed solutions for overcoming hypothetical difficulties. Forty-four diverse, independently living older adults (66-85) participated in structured group interviews in which they discussed potential solutions to manage difficulties presented in four scenarios: perceptual, mobility, physical, and cognitive difficulties. The proposed solutions were classified using the Selection, Optimization, and Compensation (SOC) model. Participants indicated they would continue performing most tasks and reported a range of strategies to manage home maintenance challenges. Most participants reported that they would manage home maintenance challenges using compensation; the most frequently mentioned compensation strategy was using tools and technologies. There were also differences across the scenarios: Optimization was discussed most frequently with perceptual and cognitive difficulty scenarios. These results provide insights into supporting older adults’ potential needs for aging-in-place and provide evidence of the value of the SOC model in applied research.
Headache in Children
Authors: Ravid Sarit , Gordon Shirie , Schiff Aharon , Shahar Eli
Published: August 2012

The purpose of this retrospective study was to compare headache etiology, type, and burden and the learning and behavioral profile in children with early-onset (under 6 years) and late-onset (8-12 years) headaches. The study included 133 patients, 35 in the early-onset group and 98 in the late-onset group. Headache diagnosis was based on International Classification of Headache Disorders -II (ICHD-II) criteria. Learning profile and behavioral problems were assessed by parental reports. Tension headache was the most common diagnosis in the early-onset headache group (51.4%). No significant differences were found between the age groups with regard to headache etiology, disability, abnormal neuroimaging results, school performance, or attention problems. Nevertheless, the early-onset group patients had a significantly higher prevalence of behavioral problems: 25.7% versus 11.2% ( P < .02). The authors suggest that early age of headache onset does not imply a harmful etiology or a relentless headache disability or burden.
Neuropsychological Development in Preschool Children Born With Asymmetrical Intrauterine Growth Restriction and Impact of Postnatal Head Growth
Authors: Klarić Andrea Šimić , Galić Slavka , Kolundžić Zdravko , Bošnjak Vlatka Mejaški
Published: August 2012

Neuropsychological development and the impact of postnatal head growth were studied in preschool children with asymmetrical intrauterine growth restriction. Examinees born at term with a birth weight below the 10th percentile were matched to the control group according to chronological and gestational age, gender, and maternal education. Fifty children were in each group, with a mean age of 6 years, 4 months. The Touwen neurological examination, the Čuturić developmental test, an imitative hand positions test, and a visual attention test were performed. There were significant differences ( P< .03) in motor variables, the developmental quotient, and the imitative hand positions test. Fine motor skills had the most discriminative power. Relative growth of the head in relation to weight gain was positively correlated to neurocognitive outcome. Intrauterine growth–restricted children with a current head circumference ≤10th percentile had poorer outcomes. Conclusively, intrauterine growth restriction has a negative impact on neurocognitive development. Slow postnatal head growth is correlated with a poorer neuropsychological outcome.
Pediatric Acute Transverse Myelitis Overview and Differential Diagnosis
Authors: Wolf Varina L. , Lupo Pamela J. , Lotze Timothy E.
Published: August 2012

Acute transverse myelitis is a clinical syndrome affecting the spinal cord, which is characterized by acute onset of motor, sensory, and autonomic dysfunction. Approximately 20% of cases of acute transverse myelitis occur in children. This review summarizes the current published literature on acute transverse myelitis, including epidemiology, diagnostic criteria, pathogenesis, clinical presentation, clinical evaluation, and differential diagnosis. The article also summarizes the neuroimaging features, acute and chronic complications, treatments, and prognosis of acute transverse myelitis in the pediatric population. The initial evaluation centers on differentiation from other causes of myelopathy, and cases are further divided into idiopathic or disease-associated acute transverse myelitis. Correct diagnosis is important for treatment and prognosis. Treatment begins with intensive surveillance for acute life-threatening respiratory or autonomic complications. Immunomodulating therapy is recommended for noninfectious causes, using high-dose intravenous corticosteroids or plasma exchange. Other therapeutic options are also discussed. Prognosis depends on a number of factors, and evidence suggests that the majority of children have a good outcome. A small percentage of children diagnosed with acute transverse myelitis later are diagnosed with other demyelinating diseases, especially neuromyelitis optica, or multiple sclerosis. The most common long-term complications of acute transverse myelitis are urinary, motor, or sensory dysfunction.
Immobilization of enantioselective lipase on soluble supports for kinetic resolution of drug intermediates
Authors: Chaubey Asha , Parshad Rajinder , Taneja Subhash C , Deokar Sarika , Raman Rajan C , Ponrathnam Surendra
Published: August 2012

The microbial lipase, Arthrobacter sp. lipase (MTCC 5125), from the Indian Institute of Integrative Medicine repository, is known as an effective catalyst for high enantioselective kinetic resolution of drug intermediates. The ABL was immobilized on water-soluble linear supports by covalently binding it to the epoxy groups on the N-vinyl pyrrolidone/allyl glycidyl ether and N-vinyl pyrrolidone/glycidyl methacrylate copolymers. The immobilized lipase, on different soluble supports, had 90–110 mg/g protein binding and 500–700 U/g hydrolysis activities for tributyrin substrate. These copolymers had soluble/insoluble characteristics in different pH ranges, which is an advantage over insoluble copolymers. A soluble polymer at neutral pH provided better accessibility to the immobilized enzyme, which was recovered by precipitation at pH 2–3 for reuse. Kinetic resolution of racemic acyl derivatives of chiral auxiliaries and drug intermediates, namely, phenyl ethanol, aminoalcohol, and fluoxetine intermediate resulted in a significant enhancement in enantioselectivity (99%).
The GENESIS Project (GENeralized Early Sepsis Intervention Strategies)
Authors: Cannon Chad M. , Holthaus Christopher V. , Zubrow Marc T. , Posa Pat , Gunaga Satheesh , Kella Vipul , Elkin Ron , Davis Scott , Turman Bonnie , Weingarten Jordan , Milling, Truman J. , Lidsky Nathan , Coba Victor , Suarez Arturo , Yang James J. , Rivers Emanuel P.
Published: August 2012

Background: Improved outcomes for severe sepsis and septic shock have been consistently observed with implementation of early best practice intervention strategies or the 6-hour resuscitation bundle (RB) in single-center studies. This multicenter study examines the in-hospital mortality effect of GENeralized Early Sepsis Intervention Strategies (GENESIS) when utilized in community and tertiary care settings. Methods: This study was comprised of 2 strategies to assess treatment. The first was a prospective before-and-after observational comparison of historical controls to patients receiving the RB after implementation of GENESIS in 4 community and 4 tertiary hospitals. The second was a concurrent examination comparing patients not achieving all components of the RB to those achieving all components of the RB in 1 community and 2 tertiary care hospitals after implementation of GENESIS. These 4 subgroups merged to comprise a control (historical controls treated before GENESIS and RB not achieved after GENESIS) group and treatment (patients treated after GENESIS and RB achieved after GENESIS) group for comparison. Results: The control group comprised 1554 patients not receiving the RB (952 before GENESIS and 602 RB not achieved after GENESIS). The treatment group comprised 4801 patients receiving the RB (4109 after GENESIS and 692 RB achieved after GENESIS). Patients receiving the RB (treatment group) experienced an in-hospital mortality reduction of 14% (42.8%-28.8%, P < .001) and a 5.1 day decrease in hospital length of stay (20.7 vs 15.6, P < .001) compared to those not receiving the RB (control group). Similar mortality reductions were seen in the before-and-after (43% vs 29%, P < .001) or concurrent RB not achieved versus achieved (42.5% vs 27.2%, P < .001) subgroup comparisons. Conclusions: Patients with severe sepsis and septic shock receiving the RB in community and tertiary hospitals experience similar and significant reductions in mortality and hospital length of stay. These findings remained consistent when examined in both before-and-after and concurrent analyses. Early sepsis intervention strategies are associated with 1 life being saved for every 7 treated.
Applications of Motivational Interviewing in Career Counseling
Authors: Stoltz Kevin B. , Young Tabitha L.
Published: August 2012

The Protean and Boundaryless career paradigms are calling for new ways to provide career counseling to clients. Career counselors need methods for facilitating client’s career transition across all stages of career development. This facilitation requires career counselors to be armed with methods for promoting client’s autonomy, responding to client resistance, and addressing client’s self-efficacy. In this article, career counseling is introduced with a Motivational Interviewing (MI) approach. First, an overview of career transition is presented. Then an application of MI as a component of the career counseling process is reviewed along with seven distinct counseling processes: (a) establishing the therapeutic relationship, (b) client assessment, (c) developing discrepancies, (d) rolling with resistance, (e) addressing client self-efficacy, (f) establishing empathy, and (g) transition/termination. Additionally, the article discusses the theoretical tenets, empirical support, and applications of MI for career counselors.