bluuebunny/crossref_metadata_2025 huggingface dataset:
Accuracy of the robot‐assisted procedure in deep brain stimulation
Authors: Goia Alice , Gilard Vianney , Lefaucheur Romain , Welter Marie‐Laure , Maltête David , Derrey Stephane
Published: August 2019

Introduction

The use of a robot‐assisted technology becomes very competitive. The aim of this work was to define the accuracy of robotic assistance in deep brain stimulation surgery and to compare results with that in the literature.

Methods

We retrospectively reviewed the accuracy of lead implantation in 24 consecutive patients who had robot‐assisted (ROSA, Zimmer‐Biomet) surgery for the treatment of movement disorders. Intended stereotactic coordinates (x, y, z) of contact 0 (the most distal contact at the tip of the electrode) of each definitive lead were compared with actual coordinates obtained by a postoperative CT scan. For each lead, the euclidian 3D distance between the actual and intended location of contact 0 was calculated.

Results

The euclidian 3D distances between the intended and actual location of the contact 0 were 0.81 mm on the right side and 1.12 mm on the left side.

Discussion

Robot‐assisted technology for stereotactic surgery is safe and accurate. The association with a 3D flat‐panel CT scan is an optimized procedure for deep intracranial electrode implantation.
Ethylene Biosynthesis, Signaling, and Crosstalk with Other Hormones in Rice
Authors: Zhou Yang , Xiong Qing , Yin Cui‐Cui , Ma Biao , Chen Shou‐Yi , Zhang Jin‐Song
Published: August 2019

Ethylene is a multifunctional hormone involved in regulating plant development, conferring adaptive growth, and responding to biotic/abiotic stresses. Rice is a monocotyledonous crop and usually grows in water environments with some unique features. Here, ethylene biosynthesis, signaling, and interaction with other hormones in rice are summarized and discussed in comparison to those from Arabidopsis and/or other plants. Ethylene biosynthesis in rice responds to internal developmental signals and external stimuli such as grain filling, leaf senescence, darkness, mechanical resistance, hypoxia, chill, salt stress, and metal ions. Gene expression regulation in ethylene biosynthesis pathway shows time and spatial specificity. Through mutant analysis and homologue analysis, an ethylene signaling pathway is proposed in rice, and conserved components/mechanisms as well as new components/mechanisms are identified. Ethylene widely interacts with other hormones in rice by synergy or antagonism. Normally, auxin and gibberellin are synergistic with ethylene to regulate growth, while abscisic acid is antagonistic to ethylene in reproductive growth and various stress response. Ethylene diminishes jasmonic acid–inhibited elongation growth, but synergistically promotes leaf senescence. All these studies provide novel insights into the ethylene biology in rice and other crops, and may facilitate breeding for cultivars with better agronomic traits.
SIRT1 Activation Promotes β-Cell Regeneration by Activating Endocrine Progenitor Cells via AMPK Signaling-Mediated Fatty Acid Oxidation
Authors: Wu Shang Ying , Liang Juan , Yang Bao Chen , Leung Po Sing
Published: August 2019

Induction of β-cell regeneration from endogenous cells represents a highly promising strategy in stem cell-based treatment for patients with diabetes. Recently, calorie restriction has been shown to affect the regulation of tissue and cell regeneration, including β cells, via metabolic related mechanisms. Here, we examined the potential utility of sirtuin 1 (SIRT1), a calorie restriction mimetic, for stimulating β-cell regeneration and the underlying mechanisms of such stimulation. The present results showed that SIRT1 activation with SRT1720 promoted β-cell regeneration in streptozotocin (STZ)-induced β-cell-deficient neonatal rats. This beneficial effect involved enhanced activation of neurogenin3 (NGN3)-positive endocrine progenitors from pancreatic ductal cells, rather than an expansion of residual β cells. A dynamic expression profile of SIRT1 was observed in endocrine progenitors both during β-cell regeneration in neonatal rats and in the second transition phase of mouse pancreas development. Consistently, SRT1720 treatment upregulated endocrine progenitor differentiation in cultured pancreatic rudiments. Upregulation of NGN3 by SIRT1 activation was through stimulating AMP-activated protein kinase (AMPK) signaling-mediated fatty acid oxidation (FAO) in human pancreatic progenitor cells; AMPK inhibition abolished these effects. The present findings demonstrate a promotional effect of SIRT1 activation on β-cell restoration and endocrine progenitor differentiation that involves regulation of AMPK signaling-mediated FAO. Stem Cells  2019;37:1416–1428
M2 Macrophages Enhance the Cementoblastic Differentiation of Periodontal Ligament Stem Cells via the Akt and JNK Pathways
Authors: Li Xuan , He Xiao-Tao , Kong De-Qin , Xu Xin-Yue , Wu Rui-Xin , Sun Li-Juan , Tian Bei-Min , Chen Fa-Ming
Published: August 2019

Although macrophage (Mφ) polarization has been demonstrated to play crucial roles in cellular osteogenesis across the cascade of events in periodontal regeneration, how polarized Mφ phenotypes influence the cementoblastic differentiation of periodontal ligament stem cells (PDLSCs) remains unknown. In the present study, human monocyte leukemic cells (THP-1) were induced into M0, M1, and M2 subsets, and the influences of these polarized Mφs on the cementoblastic differentiation of PDLSCs were assessed in both conditioned medium-based and Transwell-based coculture systems. Furthermore, the potential pathways and cyto-/chemokines involved in Mφ-mediated cementoblastic differentiation were screened and identified. In both systems, M2 subsets increased cementoblastic differentiation-related gene/protein expression levels in cocultured PDLSCs, induced more PDLSCs to differentiate into polygonal and square cells, and enhanced alkaline phosphatase activity in PDLSCs. Furthermore, Akt and c-Jun N-terminal Kinase (JNK) signaling was identified as a potential pathway involved in M2 Mφ-enhanced PDLSC cementoblastic differentiation, and cyto-/chemokines (interleukin (IL)-10 and vascular endothelial growth factor [VEGF]) secreted by M2 Mφs were found to be key players that promoted cell cementoblastic differentiation by activating Akt signaling. Our data indicate for the first time that Mφs are key modulators during PDLSC cementoblastic differentiation and are hence very important for the regeneration of multiple periodontal tissues, including the cementum. Although the Akt and JNK pathways are involved in M2 Mφ-enhanced cementoblastic differentiation, only the Akt pathway can be activated via a cyto-/chemokine-associated mechanism, suggesting that players other than cyto-/chemokines also participate in the M2-mediated cementoblastic differentiation of PDLSCs. Stem Cells  2019;37:1567–1580
Barium chloride dose‐dependently induced heart and lung injury in Wistar rats
Authors: Omole Joseph G. , Alabi Quadri K. , Aturamu Ayodeji , Adefisayo Modinat A. , Oluwayomi Oludare , Dada Moses B. , Ige Mokolade S.
Published: August 2019

Barium (Ba) is one of the environmental pollutant metals that incite deleterious effects on human health. The present study investigated the effects of exposure to different doses of barium chloride (BaCl2) on heart and lung of Wistar rats. Rats were exposed to BaCl2 at 150, 300, and 600 mg/L for seven consecutive days. Results indicated that exposure to Ba caused heart and lung damage evidenced by significant increase in plasma lactate dehydrogenase and creatine kinase activities, total cholesterol, triglyceride, and low‐density lipoprotein‐cholesterol levels, while high‐density lipoprotein‐cholesterol level decreased when compared with control. Moreover, BaCl2 significantly decreased superoxide dismutase, catalase, and acetylcholinesterase activities as well as glutathione level in heart and lung of the treated rats. Furthermore, the dose‐dependent increase in cardiac and lung lipid peroxidation, advanced oxidative protein product and nitric oxide levels were accompanied by marked increase in metallothionein in the BaCl2‐treated rats. Administration of BaCl2 altered hematological parameters and significantly increased concentrations of interleukin‐6 in the treated rats. Histology analysis showed significant alteration in the heart and lung tissues of Ba‐treated rats. In conclusion, BaCl2‐induced heart and lung damages via disruption of antioxidant defense systems, and activation of inflammatory mediators and alteration in hematological parameters in rats.
Vacuum Pressure Measurement in Industrial Environments
Authors: Wüest Martin
Published: August 2019

High accuracy and reproducibility are the basis for outstanding product quality in the manufacturing of vacuum pressure gauges. Selective product and process controls supported by statistical process control (SPC) ensure success. Automated calibration processes traceable to the National Measuring Institute (NMI) are necessitated by the high product volume and the requirement for complete traceability. Even in industrial use under mostly non‐ideal surrounding conditions, the devices must deliver stable and accurate measured values in all production processes. Using the example of hot‐filament ionization gauges, it is shown how design modifications in the production process have reduced the measurement uncertainties of the devices from one generation to the next. In another example, the introduction of a second baffle in a capacitance diaphragm gauge, led to significant reductions in sensor drift.
Top-quark pair hadroproduction in association with a heavy boson at NLO+NNLL including EW corrections
Authors: Broggio Alessandro , Ferroglia Andrea , Frederix Rikkert , Pagani Davide , Pecjak Benjamin D. , Tsinikos Ioannis
Published: August 2019

Abstract

This work studies the associated production of a top-quark pair with a W, Z, or Higgs boson at the LHC. Predictions for the total cross sections as well as for several differential distributions of the massive particles in the final state are provided. These predictions, valid for the LHC operating at 13 TeV, include without any approximation all the NLO electroweak and QCD contributions of O (αsαj+1) with i + j = 2, 3. In addition, the predictions presented here improve upon the NLO QCD results by adding the effects of soft gluon emission corrections resummed to next-to-next-to-leading logarithmic accuracy. The residual dependence of the predictions on scale and PDF choices is analyzed.
Cancellation of one-loop corrections to scalar masses in Yang-Mills theory with flux compactification
Authors: Hirose Takuya , Maru Nobuhito
Published: August 2019

Abstract

We calculate one-loop corrections to the mass for the zero mode of scalar field in a six-dimensional Yang-Mills theory compactified on a torus with magnetic flux. It is shown that these corrections are exactly cancelled thanks to a shift symmetry under the translation in extra spaces. This result is expected from the fact that the zero mode of scalar field is a Nambu-Goldstone boson of the translational invariance in extra spaces.
Probing stop pair production at the LHC with graph neural networks
Authors: Abdughani Murat , Ren Jie , Wu Lei , Yang Jin Min
Published: August 2019

Abstract

Top-squarks (stops) play a crucial role for the naturalness of supersymmetry (SUSY). However, searching for the stops is a tough task at the LHC. To dig the stops out of the huge LHC data, various expert-constructed kinematic variables or cutting-edge analysis techniques have been invented. In this paper, we propose to represent collision events as event graphs and use the message passing neutral network (MPNN) to analyze the events. As a proof-of-concept, we use our method in the search of the stop pair production at the LHC, and find that our MPNN can efficiently discriminate the signal and back-ground events. In comparison with other machine learning methods (e.g. DNN), MPNN can enhance the mass reach of stop mass by several tens of GeV to over a hundred GeV.
Scalar electroweak multiplet dark matter
Authors: Chao Wei , Ding Gui-Jun , He Xiao-Gang , Ramsey-Musolf Michael
Published: August 2019

Abstract

We revisit the theory and phenomenology of scalar electroweak multiplet thermal dark matter. We derive the most general, renormalizable scalar potential, assuming the presence of the Standard Model Higgs doublet, H, and an electroweak multiplet Φ of arbitrary SU(2)
L
rank and hypercharge, Y. We show that, in general, the Φ-H Higgs portal interactions depend on three, rather than two independent couplings as has been previously considered in the literature. For the phenomenologically viable case of Y = 0 multiplets, we focus on the septuplet and quintuplet cases, and consider the interplay of relic density and spin-independent direct detection cross section. We show that both the relic density and direct detection cross sections depend on a single linear combination of Higgs portal couplings, λeff. For λeff ∼

$$ \mathcal{O} $$

O

(1), present direct detection exclusion limits imply that the neutral component of a scalar electroweak multiplet would comprise a subdominant fraction of the observed DM relic density.
Is chest imaging relevant in diagnosing acute respiratory distress syndrome in polytrauma patients? A population-based cohort study
Authors: van Wessem Karlijn Julia Patricia , Leenen Luke Petrus Hendrikus
Published: August 2019

Purpose

The definition of acute respiratory distress syndrome (ARDS) has often been modified with Berlin criteria being the most recent. ARDS is divided into three categories based on the degree of hypoxemia using PaO2/FiO2 ratio. Radiological findings are standardized with bilateral diffuse pulmonary infiltrates present on chest imaging. This study investigated whether chest imaging is relevant in diagnosing ARDS in polytrauma patients.

Methods

The 5-year prospective study included consecutive trauma patients admitted to a Level-1 Trauma Center ICU. Demographics, ISS, physiologic parameters, resuscitation parameters, and ARDS data were prospectively collected. Acute hypoxic respiratory failure (AHRF) was categorized as Berlin criteria without bilateral diffuse pulmonary infiltrates on imaging. Data are presented as median (IQR), p < 0.05 was considered significant.

Results

267 patients were included. Median age was 45 (26–59) years, 199 (75%) males, ISS was 29 (22–35), 258 (97%) patients had blunt injuries. Thirty-five (13%) patients died. 192 (72%) patients developed AHRF. AHRF patients were older, more often male, had higher ISS, needed more crystalloids and blood products than patients without AHRF. They developed more pulmonary complications, stayed longer on the ventilator, in ICU and in hospital, and died more often. Fifteen (6%) patients developed ARDS. There was no difference in outcome between ARDS and AHRF patients.

Conclusions

Many patients developed AHRF and only a few ARDS. Patients with similar hypoxemia without bilateral diffuse pulmonary infiltrates had comparable outcome as ARDS patients. Chest imaging did not influence the outcome. Large-scale multicenter validation of ARDS criteria is warranted to investigate whether diffuse bilateral pulmonary infiltrates on chest imaging could be omitted as a mandatory part of the definition of ARDS in polytrauma patients.
Prison Inspection and Monitoring: The Need to Reform European Law and Policy
Authors: Rogan Mary
Published: August 2019

Prison inspection and monitoring bodies are important safeguards against breaches of human rights. In recent years, prison inspection and monitoring has become a key focus for international human rights standards, particularly through the introduction of the Optional Protocol to the Convention against Torture (OPCAT) and the UN’s Standard Minimum Rules for the Treatment of Prisoners, which recognize the need for robust and effective systems of prison oversight. This article contends that European legal standards on inspection and monitoring have not kept pace with international developments. The content of European law concerning domestic-level prison inspection and monitoring is not clear, nor has it been consolidated or examined in depth. Through engaging in comparative analysis with international instruments, this article analyses standards promulgated by Council of Europe and European Union bodies on inspection and monitoring, arguing that they need reform in light of international developments. Taking the opportunity presented by the revision process for the European Prison Rules and associated commentary, the article proposes improvements to European legal frameworks. It welcomes proposals for stronger powers for inspection and monitoring bodies, advocates for a specific instrument on prison inspection and monitoring and calls for more empirical understanding of how such bodies operate in practice.
On Understanding and Testimony
Authors: Malfatti Federica Isabella
Published: August 2019

Testimony spreads information. It is also commonly agreed that it can transfer knowledge. Whether it can work as an epistemic source of understanding is a matter of dispute. However, testimony certainly plays a pivotal role in the proliferation of understanding in the epistemic community. But how exactly do we learn, and how do we make advancements in understanding on the basis of one another’s words? And what can we do to maximize the probability that the process of acquiring understanding from one another succeeds? These are very important questions in our current epistemological landscape, especially in light of the attention that has been paid to understanding as an epistemic achievement of purely epistemic value. Somewhat surprisingly, the recent literature in social epistemology does not offer much on the topic. The overarching aim of this paper is to provide a tentative model of understanding that goes in-depth enough to safely address the question of how understanding and testimony are related to one another. The hope is to contribute, in some measure, to the effort to understand understanding, and to explain two facts about our epistemic practices: (1) the fact that knowledge and understanding relate differently to testimony, and (2) the fact that some pieces of testimonial information are better than others for the sake of providing one with understanding and of yielding advancements in one’s epistemic standing.
Transport of Folded Proteins by the Tat System
Authors: Frain Kelly M. , Robinson Colin , van Dijl Jan Maarten
Published: August 2019

The twin-arginine protein translocation (Tat) system has been characterized in bacteria, archaea and the chloroplast thylakoidal membrane. This system is distinct from other protein transport systems with respect to two key features. Firstly, it accepts cargo proteins with an N-terminal signal peptide that carries the canonical twin-arginine motif, which is essential for transport. Second, the Tat system only accepts and translocates fully folded cargo proteins across the respective membrane. Here, we review the core essential features of folded protein transport via the bacterial Tat system, using the three-component TatABC system of Escherichia coli and the two-component TatAC systems of Bacillus subtilis as the main examples. In particular, we address features of twin-arginine signal peptides, the essential Tat components and how they assemble into different complexes, mechanistic features and energetics of Tat-dependent protein translocation, cytoplasmic chaperoning of Tat cargo proteins, and the remarkable proofreading capabilities of the Tat system. In doing so, we present the current state of our understanding of Tat-dependent protein translocation across biological membranes, which may serve as a lead for future investigations.
Religion and Volunteering in Marital Relationships
Authors: Kim Young-Il , Dew Jeffrey
Published: August 2019

Married people are generally more religious and do volunteer work more frequently than unmarried people. However, little is known about which religious characteristics or domains predict volunteering behaviors among married couples. Using data from a U.S. national sample of heterosexual married couples, we examine which aspects of couples’ religiosity predicted husbands’ and wives’ reports of volunteering. Results from actor-partner interdependence models indicated that performing religious observances in the home was associated with wives’ reports of volunteering. Attending religious services regularly with one's spouse was associated with higher levels of volunteering for both wives and husbands. Other domains of religiosity, such as marital sanctification and co-religionist networks, were not associated with volunteering when other religious variables were in the model.
Self-reported smoking among adolescents
Authors: Manan Norfazillah Ab , Nawi Azmawati Mohammed , Ahmad Norfazilah , Hassan Mohd Rohaizat
Published: August 2019

Background & Objective:

In the local setting, the prevalence of smoking among adolescents varies, as it is based only on self-reporting without biomarker validation. The objective of the present study was to determine the accuracy of self-reported smoking among adolescents as compared to that of the urine cotinine strip test.

Methods:

We performed a cross-sectional study of 314 adolescents aged 16 years from February 2015 to April 2015 in Putrajaya, Malaysia. The accuracy of self-reporting was assessed using a data collection sheet and was validated by the urine cotinine strip test. Three schools were chosen by the simple random method, where all Form 4 students constituted the sample unit. The kappa statistic was used for determining agreement between self-reporting and urine cotinine strip testing.

Results:

There was a substantial agreement between self-reporting and the urine cotinine strip test (kappa = 0.757, 95% confidence interval [CI]: 0.63, 0.88); there was 95.86% overall agreement. The prevalence of self-reported smoking was 8% (95% CI: 7.47, 8.53) and that of urine cotinine strip testing was 10.8% (95% CI: 10.20,11.41). There was a discrepancy with the results of the urine cotinine strip test in 8% of self-reported smokers and 3.8% of self-reported nonsmokers. Self-reporting had 67.6% sensitivity and 99.3% specificity as compared to those of urine cotinine strip testing and had 92% positive predictive value and 96.2% negative predictive value.

Conclusion:

Self-reporting can be used to assess smoking status but should be used with care among adolescents. Urine cotinine strip test validation of self-reporting enables the measurement of the true prevalence of smoking among adolescents.
Arthropod Bites and Stings Treated in Emergency Departments: Recent Trends and Correlates
Authors: Vaughn Michael G. , Holzer Katherine J. , Carbone Jason T. , Salas-Wright Christopher P.
Published: August 2019

Introduction

Despite increasing health effects of arthropod bites and associated costs, research on their frequency is limited, especially at the population level. The aim of this study was to estimate the prevalence, correlates, and recent trends in visits to US emergency departments related to arthropod bites and stings.

Methods

The prevalence of arthropod bites, including information regarding location of the bite, was calculated for years 2010 through 2014 using data from the Healthcare Cost and Utilization Project Nationwide Emergency Department Sample. Sex- and age-stratified multivariate logistic regression analyses were conducted with “arthropod bite” as the dependent variable and patient and hospital characteristics as independent variables.

Results

Overall, there were significant increases in bites over the study period with higher rates of bites in the summer months (June–August), especially among children. Individuals who seek treatment for arthropod bites in the emergency department are more likely to reside in zip codes with lower median household income and to be without insurance coverage or with Medicaid rather than private insurance. The cost of care related to arthropod bites increased approximately 40% over the study period.

Conclusions

These results provide updated surveillance on the prevalence and correlates of arthropod bites and stings in the US population.
« À la poursuite de la réforme »: Renouveaux et débats historiographiques de l’histoire religieuse et intellectuelle de l’islam,xve-xxie siècle
Authors: Mayeur-Jaouen Catherine
Published: August 2019

Résumés

L’histoire religieuse et intellectuelle de l’islam à l’époque moderne et contemporaine est souvent réduite à un récit-maître arabo-centrique et téléologique dans lequel la modernité commencerait avec l’expédition d’Égypte ou laNahḍa, la Renaissance arabe. Cette histoire verrait se succéder soufisme, réformisme musulman, islamisme, salafisme, soit une « généalogie de l’islamisme ». Dans une démarche d’histoire régressive, cet article éclaire la pluralité des voies possibles comme le caractère hétérogène des moments historiques, grâce à la présentation des dynamiques courantes de l’historiographie internationale sur l’histoire de l’islam entre lexve et lexxie siècle. Remontant vers l’amont, il s’agit de repérer les ruptures et les continuités, les lectures successives de tel auteur médiéval et de tel concept (commesalafiyya). L’article s’efforce de démontrer la nature construite de la vulgate historiographique du « réformisme musulman » de la fin duxixe siècle, comme celle sur « la pensée arabe à l’âge libéral ». Les débats sur le « néo-soufisme » et sur l’Aufklärungduxviiie siècle ont conduit à une meilleure connaissance de l’islam de la fin de l’époque moderne. Entre lexve et lexviie siècle, s’épanouit une soif de renouveau(tajdīd)en hadith, en droit musulman et en soufisme. Les recherches récentes des ottomanistes sur les processus de « confessionnalisation » auxxvie etxviie siècles montrent l’importance des facteurs politiques dans ces évolutions de l’islam à l’âge des trois Empires (moghol, safavide, ottoman).
LeLivre du désert: La vision du monde d’un lettré musulman de l’Ouest saharien auxixe siècle
Authors: Warscheid Ismail
Published: August 2019

Résumés

Cet article propose une analyse duLivre du désert (Kitāb al-bādiya), un traité de droit composé par Muḥammad al-Māmī (m. 1282/1865), un lettré musulman originaire des déserts du Tiris dans l’actuelle Mauritanie. Dans son ouvrage, l’auteur réfléchit sur l’adaptation de la charia – la loi religieuse de l’islam – aux besoins des populations pastorales de l’Ouest saharien : comment s’approprier un système normatifa prioriinsensible aux contextes nomades, étant donné que celui-ci postule l’autorité d’un État dirigé par un souverain islamique(imām)comme garant de son implémentation et suppose la ville comme cadre de l’exercice de la justice ? L’article restitue les différents contextes dans lesquels s’inscrit le propos d’al-Māmī : celui d’un notable religieux à la fois engagé dans les luttes de pouvoir entre groupes nomades et fervent partisan des mouvements de djihad en Afrique de l’Ouest auxxviiie etxixe siècles, celui d’un jurisconsulte malikite qui pense sa société dans le cadre du droit musulman postclassique, celui d’un bédouin s’interrogeant sur les implications juridico-religieuses de la distance culturelle qui sépare son monde de celui des sédentaires. Tout l’enjeu est de remettre en question les notions de centre/périphérie et de « déclin » postclassique qui continuent à structurer le champ de l’histoire intellectuelle de l’islam.
Person and deixis in Heiltsuk pronouns
Authors: Bjorkman Bronwyn M. , Cowper Elizabeth , Hall Daniel Currie , Peters Andrew
Published: August 2019

Harbour (2016) argues for a parsimonious universal set of features for grammatical person distinctions, and suggests (ch. 7) that the same features may also form the basis for systems of deixis. We apply this proposal to an analysis of Heiltsuk, a Wakashan language with a particularly rich set of person-based deictic contrasts (Rath 1981). Heiltsuk demonstratives and third-person pronominal enclitics distinguish proximal-to-speaker, proximal-to-addressee, and distal (in addition to an orthogonal visibility contrast). There are no forms marking proximity to third persons (e.g., ‘near them’) or identifying the location of discourse participants (e.g., ‘you near me’ vs. ‘you over there’), nor does the deictic system make use of the clusivity contrast that appears in the pronoun paradigm (e.g., ‘this near you and me’ vs. ‘this near me and others’). We account for the pattern by implementing Harbour's spatial element χ as a function that yields proximity to its first- or second-person argument.
Genotype × environment interaction on the yield of spring oilseed rape (Brassica napus) under rainfed conditions in Argentine Pampas
Authors: Puhl L. E. , Miralles D. J. , López C. G. , Iriarte L. B. , Rondanini D. P.
Published: August 2019

Oilseed rape seed yield has increased in the last 40 years in most countries, but this yield gain has not been accompanied by greater yield stability. The current study aimed to quantify the genotype by environment (G × E) interaction on oilseed rape yield, identify genotypes with broad adaptability and the main environmental drivers related to seed yield. A weighted two-stage mixed-model analysis was applied to official multi-environment trials of nine spring genotypes (G), in three locations (L) during 6 years (Y) on central and southern Argentine Pampas under rainfed conditions. Best linear unbiased prediction of seed yield ranged from 0.37 to 3.73 kg/ha. Fixed effect L × Y was highly significant and G variability was estimated as 130 kg/ha of standard deviation. Contrasting genotypes were identified by Shukla's stability index and two of those showed the best yield performance in the wettest year. Factor analysis explained 0.75 of total variation and discriminated genotypes with broad and specific adaptability, as well as combined environments according to the similarities in seed yield of the evaluated genotypes. Environmental loadings of Factor 2 were linearly associated with cumulative rainfall in the post-flowering period (up to 230 mm). It is concluded that (i) a significant G × L × Y interaction underlies the high variability of seed yield, (ii) two genotypes (G6 and G7) with high yield stability were identified, and (iii) G × E effects are associated with post-flowering rainfall.
But how does it develop? Adopting a sociocultural lens to the development of intergroup bias among children
Authors: McLoughlin Niamh , Corriveau Kathleen H.
Published: August 2019

We argue that adopting a sociocultural lens to the origins of intergroup bias is important for understanding the nature of attacking and defending behavior at a group level. We specifically propose that the potential divergence in the development of in-group affiliation and out-group derogation supports De Dreu and Gross's framework but does indicate that more emphasis on early sociocultural input is required.
The attack and defense games
Authors: Sheremeta Roman M.
Published: August 2019

The attack-and-defense game is a game in which an attacker (a group of attackers) has an incentive to revise the status quo and a defender (a group of defenders) wants to protect it. The asymmetry in objectives creates incompatible interests and results in a mixed-strategy Nash equilibrium. However, this equilibrium could be heavily impacted by behavioral considerations.
ALTICA'S OBSIDIAN INDUSTRIES AND THEIR PLACE IN EARLY–MIDDLE FORMATIVE OBSIDIAN EXPLOITATION IN CENTRAL MEXICO
Authors: Healan Dan M.
Published: August 2019

Survey and excavation conducted by Stoner and Nichols (2019) at Altica, located in the Basin of Mexico, recovered nearly 29,000 pieces of obsidian, most of which apparently came from the nearby Otumba source. Formal classification followed by attribute analysis revealed a number of distinct lithic industries represented in the collection, although most are represented by finished objects that do not appear to have been produced on site. Most of the material consists of flakes probably used as unmodified, informal tools and produced on expedient cores consisting of some nodules but mostly percussion blades, spent cores, and other artifacts recycled as secondary cores. I propose that Altica acquired its obsidian from workshops possibly located in an area where they apparently existed in later times and may have during the Early–Middle Formative, as well. Virtually all of the obsidian in the collection appears to have been used for domestic or subsistence activities and was not involved in production or exchange systems believed to have existed at that time. Two unusual caches containing macronodules provide some evidence to the contrary, suggesting that Altica may have been a transshipment center.
EARLY–MIDDLE FORMATIVE PERIOD SUBSISTENCE IN THE TEOTIHUACAN VALLEY, MEXICO: PRE-HISPANIC PLANT REMAINS FROM ALTICA
Authors: McClung de Tapia Emily , Acosta-Ochoa Guillermo , Martínez-Yrizar Diana , Adriano-Morán Carmen Cristina , Cruz-Palma Jorge , Chaparro-Rueda Berenice
Published: August 2019

Recent excavations at the Early–Middle Formative period site of Altica in the southern piedmont of the Teotihuacan Valley, Mexico, provide evidence for early agriculture and plant use in a rural community in the northern Basin of Mexico. In the Basin of Mexico, settled agricultural communities were present in the southern sector of the region from at least 1200 calb.c.Initial expansion into the semiarid northern sector of the Basin, however, appears to have taken place towards the end of the Early Formative, during the transition to the Middle Formative when agricultural economies based on maize cultivation became firmly established, setting the scene for increased population density and concomitant social complexity.

Altica is currently the only community in the Teotihuacan Valley spanning this transitional period that has survived in the face of intensive changes in land use over the last three millennia. Macro- and microbotanical evidence recovered from radiocarbon-dated excavated contexts at Altica provide evidence for maize cultivation and suggest a subsistence economy in transition, prior to the establishment of intensive dependence upon a broader range of domesticated and cultivated plants.
Association between hours worked in paid employment and diet quality, frequency of eating out and consuming takeaways in the UK
Authors: Sam Lucy , Craig Tony , Horgan Graham W , Macdiarmid Jennie I
Published: August 2019

Objective:

To examine associations between hours worked and diet quality, frequency of eating out and consuming takeaways.

Design:

Data were taken from the National Diet and Nutrition Survey (2008–2014). Associations between hours worked in paid employment and diet quality, assessed using the Diet Quality Index (DQI) and selected foods and nutrients, were tested using linear regression models. Associations between hours worked and frequency of eating out and consuming takeaways were tested using ordinal logistic regression models. All models were adjusted for sex, age, equivalised household income, household composition and household food role.

Setting:

UK.

Participants:

Adults (n 2154) aged 19–64 years in employment.

Results:

Mean (95 % CI) hours worked per week was 36·1 (35·6, 36·6) and mean DQI score was 41·9 (41·2, 42·5) %. Hours worked was not associated with DQI score, frequency of eating out or consuming takeaways. Hours worked was positively associated with consuming red meat, processed meat and alcohol intake. Adults working more hours had lower intake of fibre but higher total fat and saturated fat intakes if they lived in households with children.

Conclusions:

Working hours may not be the main factor driving poor-quality diets among this sample of UK adults in employment. Focusing on consumption of foods prepared outside the household may not be the most efficient way to improve diet quality as effort is needed at all levels. Although it is unclear what is driving the differences in nutrient intakes according to household composition, they are important to consider when developing interventions to improve healthy eating.
CASTING A NEW CANON: COLLECTING AND TREATING CASTS OF GREEK AND ROMAN SCULPTURE, 1850–1939
Authors: Payne Emma M.
Published: August 2019

From the mid-nineteenth century, it became de rigueur for Classics Departments to acquire casts of Greek and Roman sculpture to form reference and experimental collections. Recent scholarship has revived such casts, investigating their role as instruments of teaching and research, and their wavering popularity. This paper further examines the aims of those responsible for collecting casts, and discusses how these objectives influenced their materiality and treatment, as well as showing how the de facto creation of a new canon of casts through their repetition across the collections of different institutions contributed to the decline in their perceived importance.
Fault‐Associated Magma Conduits Beneath Volcán de Colima Revealed by Seismic Velocity and Attenuation Tomography Studies
Authors: Sychev Ilya V. , Koulakov Ivan , Egorushkin Igor , Zhuravlev Sergey , West Michael , El Khrepy Sami , Al‐Arifi Nasir , Alajmi Mamdoh S.
Published: August 2019

We present the results of tomographic studies using seismic velocity and attenuation in the area of the Colima Volcanic complex (CVC). Our dataset comprises body waves from local earthquakes recorded by the temporary seismic stations of the CODEX network in the Colima area and a few stations of the regional Mapping the Rivera Subduction Zone (MARS) networks, both deployed in 2006–2008. We obtain three‐dimensional distributions of seismic velocities and attenuation in the crust beneath the CVC area. At shallow depths, we observe a large negative anomaly to the south of CVC, coinciding with the location of the Central Colima Graben. This anomaly may represent debris avalanche deposits, as well as shallow magma reservoirs feeding the eruptions of the presently active Volcán de Colima. In contrast, the volcano edifice of Nevado de Colima, which is built of rigid igneous rocks, is associated with high‐velocity and low‐attenuation anomalies at shallow depths. In the deeper section, a major anomaly with high Vp/Vs, low Vs, and high S wave attenuation corresponds to the location of the regional Tamazula fault. As this represents a mechanically weakened zone of the crust, it may form the pathway that feeds CVC. Both velocity and attenuation models show that the fault‐associated conduit brought magma from the mantle through the lower crust to a depth of 15 km. Then, a light fraction of magma may continue to ascend, forming shallow reservoirs beneath the southern flank of CVC.
The Asymmetric Atmospheric Response to the Midlatitude North Pacific SST Anomalies
Authors: Tao Lingfeng , Sun Xuguang , Yang Xiu‐Qun
Published: August 2019

Forced by Pacific Decadal Oscillation‐related sea surface temperature (SST) anomalies with the same pattern but opposite signs in the western‐central North Pacific, nonlinear wintertime atmospheric responses are produced by a state‐of‐the‐art atmospheric general circulation model (GFDL AM2.1); that is, an obvious equivalent barotropic geopotential low appears over the cold SST forcing (“CSST”), whereas a weak baroclinic structure shows up corresponding to the warm SST forcing (“WSST”), and both of them have similar characteristics in the lower troposphere. Specifically, because of the relatively dry environment in the central North Pacific, nonlinear responses of moisture process including latent heat flux and low‐level atmosphere moisture advection induce asymmetric diabatic heating (Qd): in WSST, Qd tends to increase in the middle‐lower troposphere but decrease in the middle‐upper level, whereas it always increases in the whole troposphere in CSST. Thus, Qd has the same low‐level positive vertical gradient in both CSST and WSST, which produces similar atmospheric circulation anomalies in the lower troposphere. In turn, the asymmetric responses of low‐level temperature advection further modify air temperature meridional gradient as well as atmospheric baroclinicity in the lower troposphere, significantly shifting the transient eddy activities southward in CSST and greatly weakening their intensity in WSST, respectively. Accordingly, the transient eddy vorticity forcing primarily determines the upper‐level atmospheric responses in CSST, but it has unsystematic effects in WSST that are overtaken by Qd. Therefore, the dominance of diabatic heating in WSST and transient eddy forcing in CSST over the central North Pacific lead to the asymmetric atmospheric responses among which the asymmetry of moisture plays an essential role.
Publisher Correction: npj Computational Materials, volume 5
Authors:   npj Computational Materials
Published: August 2019

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
High incidence of atrial fibrillation after successful catheter ablation of atrioventricular nodal reentrant tachycardia: a 15.5-year follow-up
Authors: Frey M. K. , Richter B. , Gwechenberger M. , Marx M. , Pezawas T. , Schrutka L. , Gössinger H.
Published: August 2019

Atrioventricular nodal reentrant tachycardia (AVNRT) is the most common type of supraventricular tachycardia. Slow pathway (SP) ablation is the treatment of choice with a high acute success rate and a negligible periprocedural risk. However, long-term outcome data are scarce. The aim of this study was to assess long-term outcome and arrhythmia free survival after SP ablation. In this study, 534 consecutive patients with AVNRT, who underwent SP ablation between 1994 and 1999 were included. During a mean follow-up of 15.5 years, 101 (18.9%) patients died unrelated to the procedure or any arrhythmia. Data were collected by completing a questionnaire and/or contacting patients. Clinical information was obtained from 329 patients (61.6%) who constitute the final study cohort. During the electrophysiological study, sustained 1:1 slow AV nodal pathway conduction was eliminated in all patients. Recurrence of AVNRT was documented in 9 patients (2.7%), among those 7 patients underwent a successful repeat ablation procedure. New-onset atrial fibrillation (AF) was documented in 39 patients (11.9%) during follow-up. Pre-existing arterial hypertension (odds ratio 2.61, 95% CI 1.14–5.97, p = 0.023), age (odds ratio 1.05, 95% CI 1.02–1.09, p = 0.003) and the postinterventional AH interval (odds ratio 1.02, 95% CI 1.00–1.04, p = 0.038) predicted the occurrence of AF. The present long-term observational study after successful SP ablation of AVNRT confirms its clinical value reflected by low recurrence and complication rates. The unexpectedly high incidence of new-onset AF (11.9%) may impact long-term follow-up and requires further clinical attention.
Syllables are Retrieved before Segments in the Spoken Production of Mandarin Chinese: An ERP Study
Authors: Feng Chen , Yue Yuan , Zhang Qingfang
Published: August 2019

Languages may differ in terms of the functional units of word-form encoding used in spoken word production. It is widely accepted that segments are the primary units used in Indo-European languages. However, it is controversial what the functional units (syllables or segments) in Chinese spoken word production are. In the present study, Mandarin Chinese speakers named pictures while ignoring distractor words presented simultaneously, which shared atonal syllables, bodies or rhymes, or were unrelated with the name of the target pictures. Behavioral results showed that naming latencies in the 3 phonologically-related conditions were significantly shorter than those associated with the unrelated condition. EEG data indicated that the syllable-related condition modulated event-related potentials (ERPs) in a time window of 320–500 ms, the body-related condition modulated ERPs from 370–420 ms, while the rhyme-related condition modulated ERPs from 400–450 ms. The starting points for evident syllable, body, and rhyme priming effects were 322 ms, 368 ms, and 408 ms (by the Guthrie & Buchwald method) or 340 ms, 372 ms and 403 ms (by the jackknife procedure), respectively. Our findings provide a relative temporal course of syllable and segment encoding in Chinese spoken naming: Syllables are retrieved before segments, and constitute the primary processing units during the early stage of word-form encoding. Furthermore, segments and their order are retrieved incrementally from left to right when producing Chinese spoken words.
Shape transition from elliptical to cylindrical membrane tubes induced by chiral crescent-shaped protein rods
Authors: Noguchi Hiroshi
Published: August 2019

Proteins often form chiral assembly structures on a biomembrane. However, the role of the chirality in the interaction with an achiral membrane is poorly understood. Here, we report how chirality of crescent-shaped protein rods changes their assembly and tubulation using meshless membrane simulations. The achiral rods deformed the membrane tube into an elliptical shape by stabilizing the edges of the ellipse. In contrast, the chiral rods formed a helical assembly that generated a cylindrical membrane tube with a constant radius in addition to the elliptical tube. This helical assembly could be further stabilized by the direct side-to-side attraction between the protein rods. The chirality also promotes the tubulation from a flat membrane. These results agree with experimental findings of the constant radius of membrane tubules induced by the Bin/Amphiphysin/Rvs (BAR) superfamily proteins.
Furin-mediated cleavage of LRP1 and increase in ICD of LRP1 after cerebral ischemia and after exposure of cultured neurons to NMDA
Authors: Yamada Mariko , Hayashi Hideki , Suzuki Kaori , Sato Shoko , Inoue Daisuke , Iwatani Yui , Ohata Meiko , Yuan Bo , Takagi Norio
Published: August 2019

TheN-methyl-D-aspartate (NMDA) receptor has been implicated in several neurodegenerative diseases, including stroke. Low-density lipoprotein receptor-related protein 1 (LRP1) plays pivotal roles in endocytosis and signaling in the cell. Immature LRP1 is processed by furin in the trans-Golgi network (TGN) and transported to the cell surface as its mature form. Activation of mature LRP1 exerts a protective effect against glutamate-induced degeneration of the rat retinal ganglion cells, as was shown in our previous study. However, the roles of LRP1 in the pathogenesis of excitotoxic neuronal injuries remain to be determined. The aim of this present study was to achieve further insight into the pathophysiologic roles of LRP1 after excitotoxic neuronal injuries. Our findings are the first to demonstrate that LRP1 was significantly cleaved by furin after cerebral ischemia in rats as well as after exposure of cultured cortical neurons to NMDA. It was noteworthy that the intracellular domain (ICD) of LRP1 was co-localized with TGN and furin. Furthermore, a furin inhibitor inhibited the cleavage of LRP1 and co-localization of LRP1-ICD with TGN or furin. Our findings suggest that furin-mediated cleavage of LRP1 and changes in the localization of LRP1-ICD were involved in the excitotoxic neuronal injury.
Algorithms for immunochromatographic assay: review and impact on future application
Authors: Qin Qi , Wang Kan , Yang Jinchuan , Xu Hao , Cao Bo , Wo Yan , Jin Qinghui , Cui Daxiang
Published: August 2019

This review summarizes different models for the lateral flow immunoassay technology when combined with artificial intelligence and deep learning.
Polymer brush based fluorescent immunosensor for direct monitoring of interleukin-1β in rat blood
Authors: Deng Fei , Li Yi , Hossain Md Jakir , Kendig Michael D. , Arnold Ria , Goldys Ewa M. , Morris Margaret J. , Liu Guozhen
Published: August 2019

A sandwich immunosensor was successfully developed for monitoring of interleukin-1β (IL-1β) in rat whole blood.
Accurate detection of intracellular microRNAs using functional Mo2C quantum dots nanoprobe
Authors: Dai Wenhao , Lu Huiting , Yang Fan , Dong Haifeng , Zhang Xueji
Published: August 2019

A functionalized Mo2C quantum dots nanoprobe was developed for accurate detection of intracellular mature microRNAs.
Iron tungsten mixed composite as a robust oxygen evolution electrocatalyst
Authors: Wang Chizhong , Wang Rong , Peng Yue , Chen Jianjun , Li Junhua
Published: August 2019

An iron tungsten mixed composite exhibited a high activity and a long-term stability for oxygen evolution reaction electrocatalysis.