bluuebunny/crossref_metadata_2025 huggingface dataset:
Ultrasound guided percutaneous transluminal angioplasty for arteriovenous fistula and graft stenosis -----A 6-years clinical observation
Authors: Li Xiaoying , Chen Song , Liu Chang , Wu Xin , Tian Yafei , Deng Chao , Fan Fengyi , Wang Xiaomei , Gui Tianyang , Guo Lili , Pan Yanyun
Published: October 2022

Background: Percutaneous transluminal angioplasty(PTA) is the preferred treatment of vascular stenosis in arteriovenous fistula(AVF) and arteriovenous graft(AVG) in maintenance hemodialysis(MHD) patients. We observed the efficacy and influencing factors of PTA guided by Ultrasound in the treatment of AVF and AVG in our center.
Methods: The data of PTA patients under the guidance of Ultrasound in our center from September 2015 to September 2021 were collected. 284 AVF patients and 83 AVG patients met the inclusion criteria, clinical indicators, postoperative use time and patency rate of the two groups were compared, and multiple linear regression analysis was used to compare the factors affecting the postoperative use time of the two groups.
Results: The use time before (17.0(3.0, 64.6) vs 10.0(1.0, 27.9)) and after (9.0(2.0, 37.8) vs 6.0(1.0, 24.0)) PTA and high density lipoprotein concentration(1.36±0.36 vs 1.06±0.32) in AVF group were significantly higher than those in AVG group(P<0.05), and fibrinogen(4.03(2.78,6.22) vs 4.7(3.4,6.6)), blood phosphorus(1.33±0.48 vs 1.58±0.39), iPTH(408.15(22.13,1084.91) vs 509.7(83.03,1228.8)), total cholesterol(5.24±1.39 vs 5.64±1.42) and very low density lipoprotein concentration(0.51±0.27 vs 0.69±0.17) in AVF group were significantly lower than those in AVG group. The patency rates at 3, 6, 12, 24 months of AVF patients were 94.7%, 77.1%, 28.5%, 8.5%, and the patency rates at 3, 6, 12, 24 months of AVG patients were 88.0%, 54.2%, 18.1%, 3.6% respectively. Kaplan-meier analysis showed that the postoperative patency rate of AVF was significantly higher than that of AVG(P<0.05). In AVF group, the postoperative use time of PTA was related to primary disease, gender and platelet distribution width(P<0.05), while the postoperative use time of PTA was related to gender and eosinophil in AVG group(P<0.05).
Conclusion: PTA guided by Ultrasound can effectively treat AVF/AVG stenosis, which causes minimum surgical trauma and can save precious vascular resources for MHD patients, this procedure is worthy of further promotion in clinical practice.
A time-dependent momentum-resolved scattering approach to core-level spectroscopies
Authors: Feiguin Adrian , Nocera Alberto , Zawadzki Krissia
Published: October 2022

While new light sources allow for unprecedented resolution in experiments with X-rays, a theoretical understanding of the scattering cross-section is lacking. In the particular case of strongly correlated electron systems, numerical techniques are quite limited, since conventional approaches rely on calculating a response functon(Kramers-Heisenberg formula) that is obtained from a perturbative analysis of scattering processes in the frequency domain. This requires a knowledge of a full set of eigenstates in order to account for all intermediate processes away from equilibrium, limiting the applicability to small tractable systems. In this work, we present an alternative paradigm, recasting the problem in the time domain and explicitly solving the time-dependent Schr\"odinger equation without the limitations of perturbation theory: a faithful simulation of the scattering processes taking place in actual experiments, including photons and core electrons. We show how this approach can yield the full time and momentum resolved Resonant Inelastic X-Ray Scattering (RIXS) spectrum of strongly interacting many-body systems. We demonstrate the formalism with an application to Mott insulating Hubbard chains using the time-dependent density matrix renormalization group method, which does not require a priory knowledge of the eigenstates and can solve very large systems with dozens of orbitals. This approach can readily be applied to systems out of equilibrium without modification and generalized to other spectroscopies.
Study on Mechanical Properties and Microstructure of Fly-Ash-Based Geopolymer Solidified Waste Mud
Authors: Wang Qiang , Xu Huangrui , Ge Dandan , Wu Liuyan , Cai Guojun
Published: October 2022

Chemical solidification of construction mud is usually used to resolve environmental problems and problematic geotechnical engineering properties. This study investigated the feasibility of solidifying waste mud with fly ash (FA) based geopolymer, which was activated by calcium carbide residue (CCR) and sodium silicate solution (NS). The unconfined compressive strength (UCS) tests were carried out to optimize the CCR/NS ratio at various curing time, in addition, the tests involving water content, pH, X-ray diffractometry (XRD), scanning electron microscopy (SEM), and natural dehydration were also performed. The UCS results show that, when the CCR/NS ratio is 6:4, the optimal 28-day strength reaches 2.2MPa with the ratio of the activator CCR-NS to FA at 1:1. The binder can reduce the water content of the mud in the short term, with the best effect at pH value of 12. The microscopic compositions showed that calcium silicate hydrate (CSH) and aluminosilicate-Na hydrate (NASH) dominated cementitious products filled the pores and bonded with particles for strength development. The dehydrating cracking process of solidified mud and untreated mud was quantitatively analyzed using image processing method. The variation of cracks area ratio and water content during dehydration was studied. The solidified mud is suitable in subgrade projects, which may facilitate the diversion of large amounts of waste mud, industrial by-products CCR and FA from landfills.
Investigation of the reduction pattern of aftershocks in the Iranian plateau
Authors: Rostam Ghasem Ghorbani
Published: October 2022

The Iranian plateau is one of the most active and seismic areas, which is located in the Alpine-Himalayan seismic belt. This area has experienced many devastating earthquakes. The study of seismic behavior and the occurrence pattern of aftershocks of medium to large earthquakes can be important for this region. Twenty six earthquakes larger than 5 have been selected on the Iranian plateau in the last ten years to investigate their aftershocks behaviour. First the seismic parameters Mc, a and b-value were estimated by drawing the Gutenberg-Richter diagram using the maximum likelihood estimation method in ZMAP software. Then, events less than Mc were removed from the catalog. The remaining catalog was used to determine the parameters of modified Omori law for each event separately. The average value of p in Zagros and Alborz is 1.07, while this value is 0.99 for Central Iran and Kope Dagh. This can be caused by high seismic activity and rapid energy discharge by small earthquakes. Furthermore, in this study, a model for the distribution of the probability function of the waiting time of aftershock sequences of the Iranian plateau has been determined.
Three unique variations of the neurovascular course of the profunda brachii artery: a case report
Authors: Hajtovic Sabastian , Samsonov Alan P. , Schmuter Gabriella , Matthews Kiran
Published: October 2022

Purpose
To report previously undocumented variants of the neurovascular course of the profunda brachii artery.
Methods
During routine cadaveric dissection, a unique combination of variations in the neurovascular course of the profunda brachii artery was noted in the right upper extremity of a 67-year-old female cadaver.
Results
The brachial artery was observed entirely anterior to the median nerve and its roots. The median nerve received an additional contribution from a branch of the lateral cord that communicates with the medial cord. The profunda brachii artery also took abnormal origin from the subscapular artery, rather than the brachial artery, in the same limb.
Conclusion
This report presents a unique combination of three neurovascular variations in the right upper limb of a single cadaver. Understanding variability in the course and continuation of the profunda brachii artery may assist surgeons and other interventionists in safely and effectively operating within the upper extremity.
Supercritical fluid conditions to obtain a chan (Hyptis suaveolens (L.) Poit) seeds oil and its physicochemical characterization, spectroscopy and nutritional analysis.
Authors: Cervantes María Dolores Díaz , Ramírez Emma Gloria Ramos , Seco Miquel Gimeno , Montoya Juan Alfredo Salazar
Published: October 2022

The aim of this study was to obtain of chan seeds oil by supercritical fluids, and to evaluate its physicochemical properties and its quality. The optimal extraction conditions were 450 bar, 80°C, and 193 min with an extraction yield of 9.21% and 62.36% recovery. The viscosity of the oil was 104.13 mPa s, and the activation energy was 2.104 KJ/mol; primary and secondary oxidation was 1.681 and 0.662. The quality of the oils was evaluated with saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), polyunsaturated fatty acids (PUFAs), and unsaturated fatty acids (UFAs). They were also determined the atherogenicity (AI), (6.70–8.27) and thrombogenicity indices (TI), (0.075–0.094); and the hypocholesterolemic/hypercholesterolemic (HH) ratio, (19.12–33.84). The oils presented high content of fatty acids ω 3, 6, and 9, and the oxidizability was from 6.70 to 8.27, indicating good stability. The characteristics of the oil extracted were compared with the oil obtained conventionally.
Preparation of Cu-modified bacterial cellulose aerogels derived from nata de coco towards the enhanced adsorption of non-polar organic solvents
Authors: Nguyen Khoa Dang , Nguyen Hanh , Van Thanh , Nguyen Hanh , Phan Anh , Tran An , Le Phung , Le Kien , Le Ha
Published: October 2022

This study presented a simple and eco-friendly method to load copper nanoparticles on the surface of bacterial cellulose produced via the fermentation of coconut water by Acetobacter xylinum (Nata de coco). The Cu modification of BC surface was based on the reduction of copper (II) acetate by hydrazine under ambient conditions in a dispersion system of Nata de coco in water, which was followed by freeze-drying, affording lightweight Cu-containing cellulose aerogels. The structural features of the obtained aerogels were investigated by scanning electron microscopy with energy dispersive X-ray analysis (SEM/EDX), thermogravimetric analysis (TGA), powder X-ray diffraction (PXRD), and nitrogen physisorption, indicating the high cellulose crystallinity, three-dimensional matrix and homogenous dispersion of Cu species on the cellulose bundles. The Cu-modified aerogel exhibited a significantly improved adsorption capacity of cyclohexane (66.4 g/g) as compared to that of pure cellulose (45 g/g). The excellent performances of 65.1-109.6 g/g were also observed for other non-polar solvents including n-hexane, toluene, ethyl acetate, dichloromethane, and chloroform depending their density.
Microglia-mediated neurovascular unit dysfunction in Alzheimer’s disease
Authors: Huang Wenhao , Xia Qing , Zheng Feifei , Zhao Xue , Ge Fangliang , Xiao Jiaying , Liu Zijie , Shen Yingying , Ye Ke , Wang Dayong , Li Yanze
Published: October 2022

The neurovascular unit (NVU) is involved in the pathological changes in Alzheimer’s disease (AD). The NVU is a structural and functional complex that maintains microenvironmental homeostasis and metabolic balance in the central nervous system (CNS). As one of the most important components of the NVU, microglia not only induce BBB breakdown by neuroinflammation, the infiltration of peripheral WBCs and oxidative stress but also mediate neurovascular uncoupling by damage neurons, abnormal contraction of cerebral vessels and pericyte loss in AD. In addition, microglia-mediated dysfunction of cellular components in the NVU, such as astrocytes and pericytes, can destroy the integrity of the NVU and lead to NVU dysfunction. Therefore, we examined microglia to clarify the mechanism of NVU dysfunction in AD. Furthermore, existing medication advancements aimed at restoring the function of microglia and the NVU in AD are discussed.
AKT1 Regulates UHRF1 Protein Stability and Promotes the Resistance to Abiraterone in Prostate Cancer
Authors: Li Xiong , fu Yongming , Cao Tuoyu , Zou Xiaorui , Lin Jinli , Liu Youhong , Peng Yuchong , deng tanggang , Yin Linglong
Published: October 2022

Oncogenic activation of PI3K/AKT signaling pathway, together with epigenetic aberrations is the characters of castration-resistant prostate cancer(CRPC). UHRF1 as a key epigenetic regulator, plays a critical role in prostate cancer (PCa) development, and its expression is closely associated with tumor malignancy. This present study investigated the potential regulatory relationship between AKT1 and UHRF1, and further validated thein vitroandin vivoanti-PCa efficacy of AKT phosphorylation inhibitor MK2206 in combination with abiraterone. Both UHRF1 and p-AKT aberrantly overexpressed in the abiraterone-resistant PCa cells. Further studies revealed that AKT1 protein interacts UHRF1, and AKT1 directly phosphorylates UHRF1 via the site Thr 210. MK2206 induced UHRF1 protein degradation by disrupting AKT1-induced UHRF1 phosphorylation, and then reduced the interaction between UHRF1 anddeubiquitinatingenzyme USP7, while promoted the interaction between UHRF and E3 ubiquitin protein ligase (BTRC). MK2206 significantly promoted the sensitivity of abiraterone-refractory PCa cells and xenografts to abiraterone by downregulating the levels of UHRF1, and reversed the transdifferentiation of NEPC (SYP and NCAM1), even activated cell senescence (p21 upregulation) and cell apoptosis (cleaved-PARP). Altogether, our present study for the first time revealed a novel molecular mechanism of abiraterone resistance through PI3/AKT-UHRF1 pathway, and provided a novel therapeutic modality by targeting PI3/AKT1 to promote the drug sensitivity of abiraterone in PCa patients.
Isolating sensory artifacts in the suprathreshold TMS-EEG signal over DLPFC
Authors: Poorganji Mohsen , Zomorrodi Reza , Hawco Colin , Hill Aron T. , Hadas Itay , Zrenner Christoph , Rajji Tarek K. , Chen Robert , Voineskos Daphne , Blumberger Daniel M. , Daskalakis Zafiris J.
Published: October 2022

ObjectiveCombined transcranial magnetic stimulation and electroencephalography (TMS-EEG) is an effective way to evaluate neurophysiological processes at the level of the cortex. To further characterize the TMS-evoked potential (TEP) generated with TMS-EEG, beyond the motor cortex, we aimed to distinguish between cortical reactivity to TMS versus non-specific somatosensory and auditory co-activations using both single-pulse and paired-pulse protocols at suprathreshold stimulation intensities over the left dorsolateral prefrontal cortex (DLPFC).MethodFifteen right-handed healthy participants received six blocks of stimulation including single and paired TMS delivered as active-masked (i.e., TMS-EEG with auditory masking and foam spacing), active-unmasked (TMS-EEG without auditory masking and foam spacing) and sham (sham TMS coil). We evaluated cortical excitability following single-pulse TMS, and cortical inhibition following a paired-pulse paradigm (long-interval cortical inhibition (LICI)).ResultsRepeated measure ANOVAs revealed significant differences in mean cortical evoked activity (CEA) of active-masked, active-unmasked, and sham conditions for both the single-pulse (F(1.76, 24.63)=21.88 , p<0.001, η2=0.61) and LICI (F(1.68, 23.49)=10.09 , p<0.001, η2=0.42) protocols. Furthermore, global mean field amplitude (GMFA) differed significantly across the three conditions for both single-pulse (F(1.85, 25.89)=24.68 , p<0.001, η2=0.64) and LICI (F(1.8, 25.16)=14.29 , p<0.001, η2=0.5). Finally, only active LICI protocols but not sham stimulation ([active-masked (0.78±0.16, P<0.0001)], [active-unmasked (0.83±0.25, P<0.01)]) resulted in significant signal inhibition.ConclusionWhile previous findings of a significant somatosensory and auditory contribution to the evoked EEG signal is replicated by our study, an artifact attenuated cortical reactivity can reliably be measured in TMS-EEG signal with suprathreshold stimulation of DLPFC. Artifact attenuation can be accomplished using standard procedures and even when masked, the level of cortical reactivity is still far above what is produced by sham stimulation.SignificanceOur study illustrates that TMS-EEG of DLPFC remains a valid investigational tool.
Time Varying Deceleration Parameter in Cosmological Models Using Optimal Control
Authors: Ramadan Moutaz
Published: October 2022

Constructed homogeneous and isotropic Friedmann Robertson Walker(FRW) cosmological model with time dependent varying deceleration parameter and have been studied to compare its behaviorin the Universe models. The Einstein’s field equations have beensolved by applying an optimal control method and obtained generalized Hubble’s parameter in FRW space-time. We also obtain the energy density and the pressure for varies Universe models.
Monogenoidean parasites of the nasal cavities of Bryconops melanurus (Characiformes: Iguanodectidae) of the coastal drainages of the Eastern Amazon, Brazil: Proposal of Guamacotyle forficata n. gen. n. sp. (Polyonchoinea: Dactylogyridae)
Authors: Neto João Flor dos Santos , Paixão Saymon Miranda da , Domingues Marcus Vinícius
Published: October 2022

Two new species of Monogenoidea (Telethecium tiquira n. sp. and Guamacotyle forficata n. gen. n. sp.) from the nasal cavities of Bryconops melanurus (Bloch) are described from the Brazilian Eastern Amazon. Telethecium tiquira n. sp. is characterized by possessing a male copulatory organ (MCO) with two circular sclerotized brims on the base, a coiled tubular shaft having 1 ½ counterclockwise rings; an accessory piece with enlarged base, pincer-shaped at the distal portion; asclerotized calyx-shaped vaginal vestibule; and hooks with proximal shank dilatation comprising 3/4 of the shank length. The new species also differs from the congeners by lacking the protruding bag located at level of the terminal male genitalia.The monotypic Guamacotyle n. gen. is characterized by having a MCO with counterclockwise rings; an accessory piece non articulated to MCO, clamp-shaped; a sclerotized vagina with sinistrolateral aperture; ventral anchors larger than dorsal anchors; and hooks with similar sizes. The proposal of the new genus is also supported by phylogenetic analysis based on 28S rDNA, which supports the close relationship of Guamacotyle n. gen. with Cacatuocotyle papilionis and Diaphorocleidus spp., all parasites of Neotropical fishes.
Study of the photovoltaic properties of Cs and Cl co-doped FAPbI 3 based on first principles
Authors: Huang Shang-Fen , Li Hai-Xia , Liu Jun , Tao Jun
Published: October 2022

Formamidine lead iodide chalcogenide (FAPbI3) is often used as a light-absorbing layer in solar cells to alleviate the energy crisis because of its own good photovoltaic properties.however, the lack of stability is also an obstacle to the current development. It has been found that doping with different kinds of elements at different sites can enhance its stability and improve the photoelectric conversion efficiency of solar cells. In this paper, the geometry, electronic structure and optical properties of FA1 − xCsxPbI3−yCly were calculated using Cs and Cl co-doped with FAPbI3 using the first nature principle. The analysis revealed that the Goldschmidt factors of the doped system were between 0.962 and 0.974, indicating that the system could maintain a stable chalcogenide structure, and the doped system had lower energy and more stable structure. By calculating the energy bands, it is found that the doped ions have a more pronounced effect on the increase of the dispersion at the bottom of the conduction band than the decrease of the dispersion at the top of the valence band of the system, and the reduction of the effective mass of carriers is more favorable for transport. As for the optical properties, the right amount of doping is favorable to the improvement of light absorption, while the excess doping shortens the light absorption range and weakens the light absorption effect, in which FA0.875Cs0.125PbI2.958Cl0.125 has the largest light absorption coefficient. It is shown that the photoelectric properties of chalcogenide FAPbI3 can be effectively modulated by the co-doping of Cs and Cl, which can provide theoretical reference for the precise preparation of more efficient solar cells experimentally.
Threats to the thermal mineralized waters used for therapeutic purposes in Jordan
Authors: Salameh Elias
Published: October 2022

Although Jordan is a country with very limited water resources, the country is rich in its thermal mineralized water possessing curative properties, historically used for the therapy of a variety of ailments. Due to the country’s increasing water demand resulting from population growth, urbanization, and industrialization, extractions from the groundwater sources feeding the thermal mineralized springs has started to affect negatively the discharged quantities from the springs. In addition, urbanization, mining activities, over-exploited groundwater resources in general and severe drop in the level of the Dead Sea is leading to declining discharge of springs in general, and thermal mineralized in special, deteriorating water quality and contamination by human activities. In this article, the current quantitative and qualitative situation of the thermal mineralized springs is given and the threats to their discharges and quantities are discussed. In addition, some water policy changes and measures are suggested to conserve these therapeutic waters for the use of generations to come and to alleviate their depletion and quality deterioration on the social and economic state of Jordan.
P300 wave alterations are associated with worse cognitive performance in cerebellum lesions
Authors: Nanda Sourav , Lapeña-Motilva José , Misra Amar Kumar , Guha Gautam , Ghosh Sinjan , Manna Akash , Roy Soumit , Benito-León Julián
Published: October 2022

Background
The P300 wave shows a prolonged latency and reduced amplitude in patients with cognitive deficits. However, no study correlated P300 wave changes with the cognitive performance of patients with cerebellar lesions. We aimed to determine if the cognitive status of these patients is associated with P300 wave alterations.
Methods
We recruited 30 patients with cerebellar lesions from the wards of the N.R.S. Medical College, Kolkata, in West Bengal (India). The Kolkata Cognitive Screening Battery tasks and the Frontal Assessment Battery were used to assess the cognitive status and the International Cooperative Ataxia Rating Scale for cerebellar signs. We compared the results with the normative data of the Indian population.
Results
Patients had P300 wave alterations, with a significant increase in latency and a non-significant trend in amplitude. In a multivariate model, P300 wave latency was positively associated with the ICARS kinetic subscale (p = 0.005) and age (p = 0.009), regardless of sex and years of education. In the model that included cognitive variables, P300 wave latency was negatively associated with performance in phonemic fluency (p = 0.035) and construction (p = 0.009). Furthermore, P300 wave amplitude was positively associated with the FAB total score (p < 0.001).
Conclusion
Patients with cerebellar damage had an increase in latency and a decrease in the amplitude of the P300 wave. These P300 wave alterations were also associated with worse cognitive performance and some of the subscales of ICARS, reinforcing that the cerebellum has both motor and cognitive and affective functions.
WITHDRAWN: Serum metabolomics probes the molecular mechanism of action of acupuncture on metabolic pathways related to glucose metabolism in obese PCOS: a randomized controlled trial
Authors: Yang Nan , Ma Ke , Liu Weidong , Shi Zhouhua , Wang Shijun , Zhang Ning , Ren Jian , Xu Wanli , Li Yuqiu , Su Riliang , Liang Yanbo , Li Xiuyang
Published: October 2022

Background & aims:
Polycystic ovary syndrome (PCOS) is a common endocrine syndrome, and obesity is the most common clinical manifestation of PCOS. Acupuncture therapy has shown great success in the treatment of PCOS, but the mechanism of acupuncture therapy in the treatment of patients with PCOS remains unclear. The biological mechanism of acupuncture therapy is vastly different from western drugs; thus, we aimed to compare the key metabolic pathways, including citric acid and glucose metabolism in acupuncture therapy.
Methods
Sixty patients with obese polycystic ovary syndrome were randomly distributed into three groups; patients receiving (1) acupuncture treatment alone, (2) conventional western medicine treatment, and (3) acupuncture combined with western medicine treatment. A targeted metabolomics approach was used to identify small molecules and metabolites related to glucose metabolism in the serum of each group, and ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) was used to analyze different metabolic fractions.
Results
Acupuncture treatment reduced mitochondrial dysfunction and oxidative damage in the liver, and decreased insulin resistance in PCOS patients by reducing the production of many metabolites involved in the tricarboxylic acid cycle (TCA cycle), such as citric acid and succinic acid. Acupuncture therapy also regulated glycolysis and gluconeogenesis pathways upstream of the TCA cycle. Activating the enzymes involved in the key glycolytic pathways and reducing the production of lactate improved the pathological conditions (impaired energy metabolism, insulin resistance, and obesity) in patients with PCOS.
Conclusions
Acupuncture treatment improved the levels of sex hormones and energy metabolism by downregulating the TCA cycle activity and modulating glycolytic and gluconeogenic pathways. However, the intervention effects on the metabolic pathways were different between patients receiving combination therapy and patients receiving acupuncture therapy alone, suggesting that the dominant modulatory effect of western drugs may largely conceal the efficacy of acupuncture intervention.
Higher systolic blood pressure is specifically associated with better islet beta-cell function in T2DM patients with high glycemic level
Authors: Xia Zhang , Song Lijuan , Fang Dongdong , You Wenjun , Li Feng , Zheng Deqiang , Li Yuhao , Lin Lu , Dou Jingtao , Su Xin , Zhai Qi , Zuo Yingting , Zhang Yibo , Gaisano Herbert Y. , Jiang Jiajia , He Yan
Published: October 2022

Background
Patients with type 2 diabetes mellitus (T2DM) usually have high blood viscosity, which could decrease blood supply to the pancreas. Increased blood pressure (BP) has been reported as a potentially compensatory response to the maintenance of islet blood perfusion. However, the influence of BP on beta-cell function in people with diabetes remains inconsistent. This study aimed to examine the relationship between BP and beta-cell function in patients with T2DM under different HbA1c levels.
Methods
This cross-sectional study included 615 T2DM patients. Clinical data were extracted from hospital medical records. Beta-cell function was assessed with insulin secretion-sensitivity index-2 (ISSI2). Multivariable linear regression analysis and restricted cubic splines (RCS) analysis were performed to identify the association between systolic blood pressure (SBP) and ISSI2. Mediation analysis was performed to determine whether higher SBP could reduce blood glucose by enhancing beta-cell function.
Results
After adjustment of age, sex, duration of diabetes, blood lipids, Matsuda index, and drug treatment, in participants with HbA1c ≥10%, SBP was positively associated with log ISSI2 (b = 0.044, 95%CI: 0.011, 0.078), and the SBP between 140 to150 mmHg had the highest log ISSI2 (b = 0.306, 95%CI: 0.126, 0.485). RCS analyses further demonstrated an inverted U-shaped association between SBP and ISSI2 with the SBP at 146 mmHg corresponding to the best beta-cell function. Additionally, higher SBP was “paradoxically” associated with lower 2h postprandial blood glucose (PBG) when SBP < 150mmHg, which was almost exclusively mediated by ISSI2 (mediating effect=-0.057, 95%CI: -0.085, -0.029). However, SBP was not associated with ISSI2 and 2h PBG in participants with HbA1c < 10%.
Conclusions
A certain degree of elevated SBP (140–150 mmHg) was associated with better beta-cell function and reduced 2h PBG in T2DM patients with HbA1c ≥10% but not in those with HbA1c < 10%. T2DM patients with unfavorable glycemic control may benefit from higher SBP through enhanced islet beta-cell function.
Design of Peptides for Inhibiting Amyloidogenesis by Blocking Hydrophobic Interactions
Authors: Saiki Masatoshi , Shibatate Ikumi
Published: October 2022

Amyloid fibrils, formed by the mis-assembly of proteins with abnormal conformations, are responsible for several neurodegenerative disorders, including prion disease. To prevent amyloid formation, it is necessary to block aggregation of the stem-forming regions of these proteins. Here we have designed and tested peptides for blocking β-sheet aggregation based on two fundamental criteria of amyloid formation: first, the hydrophobic interactions between residues on neighboring antiparallel β-strands are formed along a fibril axis; and second, the interacting hydrophobic residues are located on only one face of the β-strands. Blocking peptides designed with hydrophilic substitutions in the stem-forming regions of barnase 1–24 (BM1-24) were prepared by solid-phase peptide synthesis using Fmoc chemistry. Their effect on amyloid formation by BM1-24 and peptides of other amyloid-forming proteins was assessed by Thioflavin T (ThT) fluorescence assay and circular dichroism (CD) spectroscopy in the far-UV region. BM1-24 showed considerable amyloid formation, as indicated by a change in ThT fluorescence intensity (ΔF > 3). The addition of blocking peptides resulted in much lower fluorescence intesity (ΔF < 0.5), showing that amyloid formation was inhibited. CD spectroscopy suggested that the blocking peptide stabilized the β-structure of BM1-24. Addition of the blocking peptide to amyloid-forming peptides of prion, Amyloid β, and Pmel 17 led to a similar decline in ΔF, suggesting that amyloid formation was also inhibited in these proteins. Our results indicate that blocking peptides, designed according to the essential linear arrangement of hydrophobic residues, is effective at inhibiting amyloidogenesis in various types of proteins.
Chromogenic amide and CHEF-based emissive receptors for Cu 2+ & Co 2+ , as well as biological anions including the notorious CN - : The impact of a molecular chameleon, enticing early career beginners
Authors: Amputu Martha , Naimhwaka Johannes , Uahengo Veikko
Published: October 2022

A rich-in-amide receptors, acrylamide-N’phenylhydrazine carbothioamide-based fluorescent probe (MA) was synthesized via a simple and one-step procedure of Schiff base condensation reaction. The structure was characterized via spectroscopic methods of 1H NMR, UV-Vis and fluorescence methods. In addition, the bench-top applications on the detection of cations and anions, in DMSO, were carried out visually and spectroscopically. As a result, MA displayed colorimetric activities once anions or cations were added, observable by naked eye detectable colour changes. The probe turned out to discriminate cations such as Cu2+, Co2+, Fe3+ and Fe2+ via colour changes, which was complemented by the changes in UV-Vis titration spectra for each individual titration. Moreover, the addition of anions (F-, AcO-, CN- and OH-) to MA had colorimetric impacts observable by naked eyes, and complemented by spectral changes upon UV-Vis analysis. The probe was fluorometrically responsive to the addition of cations (Co2+, Cu2+, Ni2+ and Fe2+) and anions (F-, AcO-, CN- and OH-), both in DMSO, which have all resulted in chelation-based fluorescence enhancement (CHEF), with Co2+ and AcO- complexes exhibiting high affinity of the host-guest species. Thus, MA proved to be a potential chromogenic-fluorogenic probe, which could be used in monitoring the presence of specific cations and anions, in aqueous soluble solvent of DMSO.
Cloud Security Game Theory Scoring From Predation Models In Simulation
Authors: Alsup Damon , Putluru Mohan , Cui Suxia , Zhang Yunpeng
Published: October 2022

Cloud economics results from amassing computation resources while being able to distribute workload in space and time. The backbone of this ability is virtualization, which abstracts the host hardware, sharing virtual machines. This means of interface is also a primary vehicle and target for attackers. The counter-measures to this threat consider the costs and benefits to the cloud’s essential functions. Where the future development of the cloud is also considered, this competition between attackers and victims is analogous to those modeled in extended game theory. Yet, the attacker and victim costs and benefits, expressed as utility measures necessary for game-theory methods, are elusive quantities. This paper establishes such a game as a predator-prey contest played out on a data-center environment. A set of contestant parameters are applied at the threshold of a viable model to the recognizable boundaries. Measurement of system health is extracted in relief with individual cost, benefit, and risk. An examination of metrics capable of validating extended interaction is developed. This establishes a baseline model for more elaborate expression of security in cloud economics.
Long noncoding RNA network for lncRNA-mRNA interactions throughout swine estrous cycle reveals developmental and hormonal regulations in reproductive tissues
Authors: Park Yoon-Been , Lim Byeonghwi , Kim Jun-Mo
Published: October 2022

Background
The mechanism of estrous cycles of pigs should be explored because their reproductive traits are useful for manipulating productivity and solving problems such as infertility. These estrous cycles should be elucidated to understand the complex interactions between various reproductive tissues (including the ovary, oviduct, and endometrium) and the complex range of hormone secretions during estrous cycles. Long non-coding RNAs (lncRNAs) regulate target genes at transcriptional, post-transcriptional, and post-translational regulation levels in various species. However, unlike mRNAs, lncRNAs in pigs have not been sufficiently annotated, and understanding at the protein level of coding genes has limitations in determining the mechanism of the reproductive traits of porcine. In this study, the lncRNAs of porcine ovary, oviduct, and endometrium were investigated on days 0, 3, 6, 9, 12, 15, and 18 of the estrous cycle. In addition, the characteristics and functions of the identified lncRNAs were explored.
Results
19,021 novel lncRNA transcripts were selected, and the comparison of the characteristics of the newly identified lncRNA and mRNA showed that similar to those of previous studies. Four lncRNA networks were chosen through network analysis. The cis-acting genes of lncRNAs included in each network were identified, and expression patterns were compared. The main lncRNAs (XLOC_021792, XLOC_017111, ENSSSCG00000050977, XLOC_000342, ENSSSCG00000050380, ENSSSCG00000045111, XLOC_008338, XLOC_004128, and ENSSSCG00000040267) were determined from the network by considering the cis-acting genes. Specific novel lncRNAs were discovered in the reproductive tissues during the swine estrous cycle, and their time-serial expression dynamics were confirmed.
Conclusions
As the main lncRNAs are involved in the development of each reproductive tissue and hormone action, they can be utilized as potential biomarkers to help improve and develop the reproductive traits of pigs.
Herbicides mixture with potent endocrine-disrupting properties in goldfish: As an early warning at environmentally relevant concentration.
Authors: Fatima Masroor , Rasool Fazle
Published: October 2022

For a meaningful interpretation of toxic effects in fish, knowledge of sub-lethal events is essential and for this reason, we have conducted a series of studies with a relevant environmental concentration of a mixture of herbicides; Atrazine, simazine, diuron and isoproturon (ASDI) pollutants and using immune (Fatima et al. 2007) and endocrinological changes as principal endpoints under controlled laboratory conditions. Goldfish (Carassius auratus) were exposed to a cumulative concentration of 50µg/l of ASDI mixture for 12 weeks which was reported above the permissible level in the drinking water of Belgium (EAEW report, 1998) and nearby aquatic environments, confirming some of these herbicides still persistence despite restriction policies (Pesce et al. 2010;Agbohessi et al. 2014).Control and exposed fish were sampled at week-4, 8, and 12. We investigated the endocrine modulatory effect of ASDI which shows a low degradation rate in water. Thus, at the realistic level of ASDI concentration, significantly increased levels of cortisol and aromatase after 4-weeks were recorded. Reduction in aromatase activity at 8 and 12 weeks is followed by estradiol (E2) showing a positive correlation between them. Hence, 11-Keto reduced significantly at 4-8 weeks and enhanced at 12 weeks. Remarkable reduction in E2 and 11-Keto may be correlated with the reduced egg production in stressed fish by these herbicides. However, no remarkable change in testosterone is observed at 4 and 12 weeks as compared to the control. ASDI mixture treatment induced remarkable induction in vitellogenin (Vtg) biomarker protein in male stressed fish. Furthermore, it may confer that modulation in the pathway of the reproductive cycle may alter the gamete quality, quantity and consequently may disrupt spawning and mating behaviour in fishes even at a realistic level of pollutant in the environment.
Climbing perch Anabas testudineus avoid expanded polystyrene pellets ingestion
Authors: Ganzha Ekaterina , Pavlov Efim , Duc Dien Tran
Published: October 2022

The climbing perch Anabas testudineus is widespread in the inland waters of Vietnam and according to its ecology could have contact with a floating plastic waste. The fragments of expanded polystyrene (EPS) detected into the fresh waters of Vietnam in Khanh Hoa, Lam Dong, Phu Yen provinces. Our study was focused on estimation of probability of ingestion of EPS pellets (size 2.5–3.5 mm) by adult climbing perch. In the experiments three types of treatment pellets were proposed to fish: 24 feed pellets (Fp), 24 expanded polystyrene pellets (Pp), 12 feed & 12 expanded polystyrene pellets (FPp). Fish grasping time of first pellet was independent in all treatment types. The time grasping of 12th pellet was insignificant in Fp (63 s) and Pp (75 s). Climbing perch was grasping and ingesting of 24th Fp significantly (p = 0.02) earlier (143 s), than grasping of 24th Pp (817 s). Fish with FPp treatment was grasping feed along with EPS pellets, but grasping of 12th Fp was significantly (p = 0.02) earlier (49 s), then 12th Pp (193 s). By the end of tests fish ingested all feed pellets. We discovered that climbing perch grasped Pp and kept them in oral cavity, but always rejected them in 100% cases. This result evidenced that climbing perch has effective defense mechanism avoiding ingestion of expanded polystyrene pellets with size 2.5–3.5 mm, which realized by taste system and tactile reception of fish.
The Set of All Natural Numbers Is Infinite and ω Can't Replace ∞
Authors: ZHANG Xin Fang
Published: October 2022

It is well known that Cantor believed that the set of all natural numbers was infinite and that ω could replace ∞. However, if we group all natural numbers and all pure decimals, we shall see that this is not the case. Indeed, by recursively defining x1=p1∈A1, xm=(pm,xm-1)∈Am, set Amm→ω contains all decimal numbers and clearly Amm→ω is finite. By recursively defining y1=q1∈B1, yn=(qn,yn-1)∈Bn, then Bnn→∞ contains all pure decimal in decimal. Therefore, when replacing ∞ with ω, Bnn→ω contains only all finite pure decimals. As a result, ω can not replace ∞.
Specific Profiles and Amplification of Resistance to Anti-tuberculosis Drugs in Tuberculosis Patients in the Republic of Karelia
Authors: Markelov Yu. M. , Belyaeva E. N. , Sunchalina T. V.
Published: October 2022

The objective: to determine the frequency of resistance of Mycobacterium tuberculosis (MTB) to the most effective anti-tuberculosis drugs in tuberculosis patients in the Republic of Karelia, to characterize cases of amplification of MTB drug resistance during chemotherapy (CT).

Subjects and Methods. MTB cultures of 1,137 tuberculosis patients were studied, the patients received chemotherapy from 2016 to 2021, among them 634 (55.8%) had multiple drug resistance (MDR). Among MBT cultures with MDR, there was a high frequency of MTB with extensive drug resistance (XDR) – 42.3% (268/634) including new cases. It provided a negative impact on the chemotherapy efficacy. Most often, amplification of MTB drug resistance was observed in patients treated as per regimen IV – 37/49 (75.5%) cases. MTB drug resistance amplified more often in the cases who were already resistant to 3 and more anti-tuberculosis drugs, 31/49 (63.3%). Most often, amplification was noted in aminoglycosides (Km, Am) and glycopeptide (Cm), (71.6% of cases). The high frequency of MTB drug resistance amplification from MDR up to XDR was due to the lack of rapid molecular genetic methods to test drug susceptibility to fluoroquinolones and aminoglycosides.
Association of Gln27Glu Polymorphism of the β2-adrenoreceptor Gene with Specific Parameters of the Immunoregulatory Cytokine Cascade and IgE Production in Patients with Bronchial Asthma
Authors: Turdibekov Kh. I. , Tashkenbaeva E. N. , Ziyadullaev Sh. Kh. , Ibragimov S. Kh.
Published: October 2022

The objective: to study the level of serum cytokines IL-4, IFN-γ and the activity of IgE production in patients with bronchial asthma (BA) with the consideration of the Gln27Glu-polymorphism of the β2-AR gene.

Subjects and Methods. 130 people of Uzbek ethnicity were examined including 83 patients with BA. BA patients were divided into groups according to the international classification of the World Health Organization and the GINA 2006 diagnostic criteria. Genotyping was performed by polymerase chain reaction technology and restriction fragment analysis.

Results. In the group with allergic BA, patients with the Gln27Gln-polymorphic variant of the β2-adrenergic receptor gene had an average IgE value (1,664.20 ± 293.29 pg/ml) higher versus patients with the Gln27Glu genotype (338.40 ± 121.33 pg/ml; p < 0.01). No significant relationship between the Gln27Glu polymorphism of the β2-adrenergic receptor gene and the activity of inductor cytokines was found. The Gln27Gln genotype of the β2-adrenergic receptor gene in patients with bronchial asthma, especially in the allergic form of the disease, is associated with hyperproduction of IgE.
Propaganda dan Perang Saraf British di Tanah Melayu melalui Malayan Film Unit (MFU) 1946–1957
Authors: Chellitda Farhana Gunaish  , Mohd Firdaus Abdullah  , Wan Hasmah Wan Teh
Published: October 2022

This research aims to look at the role of the Malayan Film Unit (MFU) which was used as a medium of propaganda and psychological warfare by the British in Malaya from 1946 to 1957. The establishment of the MFU was seen as one of the last British strategies in boosting their image and power in Malaya after the end of the Second World War. Through the MFU, various films were produced based on political, economic, and social themes in which the British had a stake. This research is qualitative in nature and fully uses historical research methods. Materials and resources were obtained from the National Archives of Malaysia, National Archives of Kedah/Perlis, the Hamzah Sendut Library in Universiti Sains Malaysia, the Tun Sri Lanang Library in Universiti Kebangsaan Malaysia, the Kedah State Public Library, and many others. The results show that the MFU played an important role as a propaganda tool and as a part of British psychological warfare in Malaya until its independence. Furthermore, the MFU was maintained post-independence and was a propaganda tool of the Federal Government of Malaya’s psychological warfare.
Penyelidikan ini bertujuan untuk melihat peranan Malayan Film Unit (MFU) yang telah menjadi medium propaganda dan perang saraf oleh British di Tanah Melayu dari tahun 1946 sehingga tahun 1957. Penubuhan MFU dilihat antara strategi terakhir British dalam mengangkat imej dan kuasa mereka di Tanah Melayu selepas tamatnya Perang Dunia Kedua. Melalui MFU, pelbagai filem telah dihasilkan berdasarkan tema-tema terpilih seperti politik, ekonomi, dan sosial yang mempunyai kepentingan kepada British. Penyelidikan ini berbentuk kualitatif dan menggunakan sepenuhnya kaedah penyelidikan sejarah. Bahan dan sumber diperoleh dari Arkib Negara Malaysia, Arkib Negara cawangan Kedah/Perlis, Perpustakaan Hamzah Sendut (Universiti Sains Malaysia), Perpustakaan Tun Sri Lanang (Universiti Kebangsaan Malaysia), Perpustakaan Awam Negeri Kedah dan lain-lain lagi. Hasil kajian menunjukkan, MFU berperanan penting sebagai alat propaganda dan perang saraf British di Tanah Melayu sehingga kemerdekaan tanah air. Malah selepas kemerdekaan, MFU dikekalkan dan telah menjadi alat propaganda dan perang saraf Kerajaan Persekutuan Tanah Melayu.
Bounds on quantum evolution complexity via lattice cryptography
Authors: Craps Ben , De Clerck Marine , Evnin Oleg , Hacker Philip , Pavlov Maxim
Published: October 2022

We address the difference between integrable and chaotic motion in
quantum theory as manifested by the complexity of the corresponding
evolution operators. Complexity is understood here as the shortest
geodesic distance between the time-dependent evolution operator and the
origin within the group of unitaries. (An appropriate
'complexity metric' must be used that takes into account the relative difficulty of performing 'nonlocal’
operations that act on many degrees of freedom at once.) While simply
formulated and geometrically attractive, this notion of complexity is
numerically intractable save for toy models with Hilbert spaces of very
low dimensions. To bypass this difficulty, we trade the exact definition
in terms of geodesics for an upper bound on complexity, obtained by
minimizing the distance over an explicitly prescribed infinite set of
curves, rather than over all possible curves. Identifying this upper
bound turns out equivalent to the closest vector problem (CVP)
previously studied in integer optimization theory, in particular, in
relation to lattice-based cryptography. Effective approximate algorithms
are hence provided by the existing mathematical considerations, and they
can be utilized in our analysis of the upper bounds on quantum evolution
complexity. The resulting algorithmically implemented complexity bound
systematically assigns lower values to integrable than to chaotic
systems, as we demonstrate by explicit numerical work for Hilbert spaces
of dimensions up to \sim 10^4∼104.
Editorial
Authors:   The University of New South Wales, Jung Jae Yup
Published: October 2022

Welcome to the second issue of the Australasian Journal of Gifted Education for 2022. First of all, I am delighted to advise that the latest (2021) ranking outcomes for the journal show that it is continuing to have substantial international reach and impact. Specifically, the CiteScore of the journal is now 1.90, which is approximately double the previous CiteScore, placing it in the second quartile of all international Education journals for the first time ever. The CiteScore is only 1.30 below the CiteScore of the number two journal in the international field of gifted education. Other metrics (i.e., SCImago Journal Rank [SJR] and the Source Normalized Impact per Paper [SNIP]) also demonstrate the standing of the journal as an outlet for high quality research in gifted education. Thank you to all the contributing scholars, the reviewers, the subscribers, and the readers of the Australasian Journal of Gifted Education for making this possible.