bluuebunny/crossref_metadata_2025 huggingface dataset:
Polyene macrolide antibiotic nanoemulsion: a proposal for the treatment of cutaneous leishmaniasis
Authors: Sosa Lilian , Espinoza Lupe Carolina , Fuentes Jhunior Marcia , Siwady Jorge Alberto , Rodríguez Rivas Fredy , Rincón Díaz María
Published: December 2022

Leishmaniasis is a neglected tropical disease that requires timely and inexpensive treatment. For this purpose, a nanoemulsion with a polyene macrolide antibiotic, or amphotericin B (NE-AmB), was developed. This study quantified the amount of drug permeated and retained in intact and lacerated human skin, simulating cutaneous leishmaniasis (CL) processes. Toxicity in macrophage and keratinocyte cell lines, activity against promastigotes and amastigotes of Leishmania tropica, in vivo irritant activity, and histological evidence was evaluated. Results. The amount of drug retained in intact and damaged skin was 750.18 ± 5.43 and 567.97 ± 8.64 µg/g/cm2, respectively. There was no permeation. No apparent toxic effect was observed in HaCaT cell lines. The IC50 of NE-AmB found for promastigotes and amastigotes was 0.26 ± 0.09 and 0.37 ± 0.05 µg/mL, respectively. NE without AmB did show antiparasitic activity. The formulation showed lower IC50 values on both parasite stages than the AmB solution. There was no skin irritation, and histology showed skin improvement with treatment. We suggest that this NE-AmB may be a candidate for in vivo studies in CL patients.
Keywords. Leishmaniasis, Amphotericin B, ex vivo permeation studies, in vitro cytotoxicity, in vitro leishmanicidal activity, Draize test, histology.
Phenotypic and genotypic investigation of three weeds residues allelopathic effect on the growth of three hybrid wheat cultivars
Authors: Kuosay Al-Doree Enas , Salem Al-Sffar Raed , radha Jasim Iman
Published: December 2022

The present study was carried out to determine the allelopathic effect of extraction of three herbs (Silybum marianum L. and Malva parviflora L. and Loliuim rigidum L. ) on three wheat cultivars (Rashid, Abo Ghrib and IPA99) on germination, growth and ear formation by classical research methods (laboratory and greenhouse experiments and molecular detection of GA3-oxase2 (TaGA3ox2-1) gene expression and its crucial role in wheat growth and Ta14S gene expression as a gene responsible for ear development. The study analyzed the influence of weed residues on the germination and growth of three wheat cultivars. According to the mean effect of aqueous weed extract on the cultivars, the laboratory experiments revealed a significant difference in all the characteristics studied.

Keywords. Weeds, hybrid wheat cultivars, allelopathy, RT-PCR.
Predictive Value of Physiological Values and Symptom Scores for Exacerbations in Bronchiectasis and Chronic Obstructive Pulmonary Disease With Frequent Exacerbations: Longitudinal Observational Cohort Study (Preprint)
Authors: Jones Thomas Llewelyn , Roberts Claire , Elliott Scott , Glaysher Sharon , Green Ben , Shute Janis K , Chauhan Anoop J
Published: December 2022

BACKGROUND

COPD (chronic obstructive pulmonary disease) and bronchiectasis are common, and exacerbations contribute to their morbidity and mortality. Predictive factors for the frequency of future exacerbations include previous exacerbation frequency and airway colonization. Earlier treatment of exacerbations is likely to reduce severity.

OBJECTIVE

This study tested the hypothesis that, in a population with bronchiectasis, COPD, or both who have frequent exacerbations and airway colonization, changes in symptom scores or physiological variables within 10 days prior to an exacerbation would allow the prediction of the event.

METHODS

We performed a 6-month, longitudinal, observational, cohort study among 30 participants with bronchiectasis, COPD, or both; at least 2 exacerbations per year; and colonization with Pseudomonas aeruginosa or Haemophilus influenzae. Daily symptom and physiological data were collected, comprising pulse rate, blood pressure, oxygen saturation, peak flow rate, step count, weight, and temperature. Exacerbations (defined as the onset of new antibiotic use for respiratory symptoms) were collected, and predictive values for abnormal values in the 10 days prior to an exacerbation were calculated.

RESULTS

A total of 30 participants were recruited, collecting a total of 39,534 physiological and 25,334 symptom data points across 5358 participant-days; these included 78 exacerbations across 27 participants, with the remaining 3 participants not having exacerbations within the 6-month observation period. Peak flow rate, oxygen saturation, and weight were significantly different at the point of exacerbation (all P<.001), but no significant trends around exacerbation were noted and no clinically beneficial predictive value was found in the overall or individually adjusted model. Symptom scores tended to worsen for 10 days on either side of an exacerbation but were of insufficient magnitude for prediction, with area under the receiver operating characteristic curve values of ranging from 0.4 to 0.6.

CONCLUSIONS

Within this small cohort with bronchiectasis, COPD, or both and airway colonization, physiological and symptom variables did not show sufficient predictive value for exacerbations to be of clinical utility. The self-management education provided as standard of care may be superior to either of these approaches, but benefit in another or larger cohort cannot be excluded.

INTERNATIONAL REGISTERED REPORT

RR2-10.2196/resprot.6636
The “Loci” of Misinformation and Its Correction in Peer- and Expert-Led Online Communities for Mental Health: Content Analysis (Preprint)
Authors: Bizzotto Nicole , Schulz Peter Johannes , de Bruijn Gert-Jan
Published: December 2022

BACKGROUND

Mental health problems are recognized as a pressing public health issue, and an increasing number of individuals are turning to online communities for mental health to search for information and support. Although these virtual platforms have the potential to provide emotional support and access to anecdotal experiences, they can also present users with large amounts of potentially inaccurate information. Despite the importance of this issue, limited research has been conducted, especially on the differences that might emerge due to the type of content moderation of online communities: peer-led or expert-led.

OBJECTIVE

We aim to fill this gap by examining the prevalence, the communicative context, and the persistence of mental health misinformation on Facebook online communities for mental health, with a focus on understanding the mechanisms that enable effective correction of inaccurate information and differences between expert-led and peer-led groups.

METHODS

We conducted a content analysis of 1534 statements (from 144 threads) in 2 Italian-speaking Facebook groups.

RESULTS

The study found that an alarming number of comments (26.1%) contained medically inaccurate information. Furthermore, nearly 60% of the threads presented at least one misinformation statement without any correction attempt. Moderators were more likely to correct misinformation than members; however, they were not immune to posting content containing misinformation, which was an unexpected finding. Discussions about aspects of treatment (including side effects or treatment interruption) significantly increased the probability of encountering misinformation. Additionally, the study found that misinformation produced in the comments of a thread, rather than as the first post, had a lower probability of being corrected, particularly in peer-led communities.

CONCLUSIONS

The high prevalence of misinformation in online communities, particularly when left uncorrected, underscores the importance of conducting additional research to identify effective mechanisms to prevent its spread. This is especially important given the study’s finding that misinformation tends to be more prevalent around specific “loci” of discussion that, once identified, can serve as a starting point to develop strategies for preventing and correcting misinformation within them.
Щодо значення гіпергомоцистеїнемії в розвитку цереброваскулярної і кардіоваскулярної патології
Authors: Zozulya I.S. , Volosovets A.O. , Bezsmertna G.V.
Published: December 2022

У роботі подані результати вивчення частоти гіпергомоцистеїнемії в здорових людей і хворих зішемічним інсультом і транзиторними ішемічними атаками, висвітлено взаємодію гіпергомоцистеїнемії з іншими факторами ризику. Визначено їх роль у прогресуванні цереброваскулярних захворювань і вплив на їх тяжкість. З’ясовано вплив вікових і статевих чинників на поширеність метаболічних факторів, зокрема гіпергомоцистеїнемії.
A clusters analysis of energy sector: Monitoring Brazilian matrix
Authors: Silva Rodrigo Speckhahn Soares da , Junior Claudelino Martins Dias
Published: December 2022

The present study provides an overview of energy production in Brazil and in other 53 (fifty-three) countries, considering 18 (eighteen) variables of interest collected from the World Bank’s database of years 1997, 2002, 2007 and 2012. With an essentially quantitative approach and used Principal Components Analysis (PCA), 10 (ten) variables were adopted that most contributed to the variance of the data. In parallel, through the clustering technique, the countries were grouped by common characteristics, observing that Brazil, even with privileged water resources, has walked in the opposite direction of the other countries, presenting an involution in some reference indicators. The main contribution of the study is the design of an analysis model capable of defining, preliminarily, a design of the Brazilian energy matrix from the end of the 90s to the year 2012, a period that includes the publication of the secondary data used.
RUSSIAN SPECIAL OPERATION IN CRIMEA IN 2014
Authors: Parezanovic Marko
Published: December 2022

The Russian special operation of capturing the Crimean Peninsula represents a highly complex military-political operation, carried out by the Russian Federation at the end of March 2014, shortly after the color revolution in Ukraine. With the skillful, lightning-fast and daring engagement of its military forces and special services, Russia captured and established itself in Crimea in a short time, to the surprise not only of official Kyiv, but also of the entire international public. Using available legal and political mechanisms, Russia supported the implementation of a series of activities that resulted in the declaration of independence of the Republic of Crimea and its accession to the Russian Federation.
POLITICS BETWEEN AUTHORITY AND POWER
Authors: Glisin Vanja
Published: December 2022

Book review :

Ljubiša Despotović. 2022. Politics between Authority and Power: Introduction to Political Science. Novi Sad: Nacional, p. 294.
La « mission Millet » : nouvelles données sur la collaboration de Gabriel Millet et de Djurdje Bošković
Authors: Ciric Jasmina
Published: December 2022

Dans ce texte sont analysés certains détails inédits concernant la collaboration de Gabriel Millet et de Djurdje Bošković. La collaboration entre les deux chercheurs date de 1927 – année de la tenue du Deuxième congrès international des byzantinistes à Belgrade, quand Bošković a été délégué auprès de Millet en tant que collaborateur technique. Les deux chercheurs ont poursuivi leur collaboration au cours des années 1934 et 1935, lors de la mission exploratoire organisée grâce au soutien financier du Gouvernement français. Plusieurs lettres des deux savants témoignent des préparatifs en vue de cette mission. Parmi les documents de Djurdje Bošković, conservés dans son Legs à l’Institut archéologique à Belgrade, on garde l’ébauche d’une lettre datant de novembre 1934. Cette lettre, envoyée par Bošković au Ministère des affaires étrangères, nous informe sur les caractéristiques de l’équipement technique que Millet a importé au Royaume de Yougoslavie au début de mai 1934 dans l’objectif de photographier des églises anciennes serbes.
La transition politique des années 1990 : de la tentative de conciliation à la naissance de mouvements nationalistes, les fondements du basculement illibéral en Europe post-communiste
Authors: Soulier Pauline , Lesauries Valentin
Published: December 2022

La transposition des grilles d’analyse d’A.-D. Smith relative aux stratégies de conciliation de légitimité et de celle de Miroslav Hroch étudiant les mouvements nationalistes permettent de comprendre la transition politique en Europe postcommuniste. Surplombée par une européanisation rapide, cette transition se révèle fragile dès la fin des années 2008. Les nouveaux États indépendants absorbent avec difficulté l’enchainement de crises (financière, migratoire et sanitaire). Dès lors les gouvernements opèrent un repli nationaliste qui se traduit par des pratiques illibérales.
Le Kosovo(-Métochie) et la question de la souveraineté nationale et internationale
Authors: Dimitrijevic Dejan
Published: December 2022

Depuis la fin des années 1970, l’idéologie libérale mène une croisade pour que le monde globalisé adopte des règles de fonctionnement qui permettent à l’économie et à la finance de générer toujours plus de profits au bénéfice des actionnaires. Dans le récit qui accompagne cette croisade libérale, l’Etat est présenté comme une institution anachronique nuisible à l’harmonie globale, dont les piliers sont la liberté du marché et des mœurs. Dans ces conditions, l’acharnement des puissances Occidentales de créer de nouveaux Etats intrigue. Cet article propose d’examiner le processus de création de l’Etat du Kosovo*, afin de mieux comprendre les enjeux de l’époque contemporaine. Ce processus, qui n’offre aucune garantie d’aboutissement, est le résultat d’une campagne militaire menée par les EU, et suivie par dix-huit autres pays membres de l’OTAN.
Les relations économiques entre la France et la Serbie – aperçu historique et tendances contemporaines
Authors: Rapaic Stevan , Matijevic Andrea
Published: December 2022

Dans cet article, les auteurs tentent de présenter systématiquement l’évolution des relations économiques entre la Serbie et la France. Pour cela, les auteurs partent d’une revue de l’histoire des relations économiques, nécessaire à la compréhension du contexte contemporain. La revue historique comprend une analyse des relations économiques entre la Serbie et la France à travers les étapes suivantes : 1. 1878-1918 ; 2. 1918-1939 ; 3. 1945-1991, et 4. 1991-2000. Les tendances contemporaines sont examinées pour la période allant des changements politiques en Serbie en 2000 jusqu’au 2020. L’histoire des relations économiques indique l’importance du niveau de coopération économique pour le caractère des relations politiques globales entre les États. Presque en règle générale, on peut remarquer qu’un niveau plus élevé de coopération économique a entraîné l’amélioration des relations politiques entre les deux pays, et vice versa, et que les années ’90 représentent la période des relations économiques et politiques les plus faibles de l’histoire de relations entre la Serbie et la France. Avec ce niveau de relations économiques, on est entrée en un nouveau millénaire. L’observation de la période postérieure aux années 2000 indique cependant l’amélioration des relations économiques entre les deux pays, observée à travers les relations de commerce extérieur et le mouvement des investissements directs étrangers (IDE). La base de l’amélioration des relations est la libéralisation des relations commerciales entre la Serbie et l’Union européenne (UE) réalisée par la conclusion de l’Accord de stabilisation et d’association (ASA), ainsi que l’arrivée d’entreprises françaises en Serbie, qui a été lancée au début des années 2000 avec l’ouverture de l’économie serbe. Cette évolution est à la base d’attentes optimistes quant à une coopération économique productive entre les deux pays dans les années à venir.
La ejemplificación en Lógica viva
Authors: Seoane José
Published: December 2022

Lógica viva de Vaz Ferreira (1910) es considerada una original contribución a la reflexión lógica ---por ejemplo, recientemente, Vega Reñón (2013 y 2019) ha resaltado su relevancia---. Lógica viva puede interpretarse como la fundamentación, exposición e implementación parcial de un programa de indagación lógica, que anima una relectura de los contenidos tradicionales y una ampliación del elenco tradicional de paralogismos (Seoane 2019b). Al hacerlo entrelaza invención lógica y pedagógica. Desde esta óptica, resulta clave el contraste entre su estilo de ejemplificar y el estilo usual de los manuales de lógica. Este trabajo propone una interpretación de la política de ejemplificación de Lógica viva.
Paliacates rojos
Authors: Méndez Rojas Diana Alejandra , Ortega Jaime
Published: December 2022

Este artículo aborda la trayectoria de la Unión Nacional Infantil (UNI), iniciativa del Partido Comunista Mexicano (PCM) a finales de la década de 1970, orientada a defender los derechos de la niñez. La creación y el fortalecimiento de esta organización —junto con la defensa de los derechos de la mujer, la libertad sexual y el cuidado del ambiente— fue un claro indicador de la modernización de la izquierda mexicana. Sin renunciar a su discurso tradicional centrado en demandas obreras y campesinas, la izquierda pugnó por poner nuevos conflictos y problemas sociales en la discusión política nacional. El presente artículo analiza el desarrollo de la UNI en el curso modernizador de las izquierdas mexicanas, en particular en las transformaciones internas del PCM.
Incursiones indias en el norte de Tamaulipas durante la primera mitad del siglo XIX
Authors: Olvera Charles Fernando
Published: December 2022

El objetivo del presente artículo es identificar las etapas de las incursiones indias en el norte de Tamaulipas durante el largo periodo de la primera mitad del siglo xix. Se postula la continuidad y la adaptación de varios factores que convergieron en la época colonial e influyeron en el curso de las irrupciones y el trato de las fuerzas colonizadoras a las tribus nómadas. Su estudio permite tener una visión más completa y profunda del fenómeno y de su papel en la formación de la frontera norte de México. Una conclusión principal es que las autoridades mexicanas y americanas fueron incapaces de desarrollar mecanismos adecuados para incorporar a los nativos al nuevo espacio fronterizo y a las sociedades ahí germinadas. Para éstos resultó difícil dejar su tipo de vida tradicional y adaptarse a las condiciones creadas por la redefinición de la frontera. Las incursiones fueron un claro ejemplo de este accidentado proceso.
camino hacia la despenalización del suicidio en la ciudad de México, 1812-1872
Authors: Beltrán Abarca Francisco Javier
Published: December 2022

Este artículo analiza la supresión de las penas y la definición jurídica novohispana del suicidio como crimen en México en el siglo XIX, según la adopción del principio liberal de la utilidad social del castigo, así como su efecto en la impartición de justicia en la ciudad de México. Mediante el análisis de expedientes judiciales, manuales de derecho y prensa, se documenta que primero fueron abolidas las penas y que el tipo delictivo fue suprimido décadas después. Ese desfase provocó confusión y disparidad en el procesamiento penal y eclesiástico de quienes se dieron muerte por su voluntad o lo hubieran intentado.
problema usurario según El Tiempo
Authors: Rodríguez Ávila Adán
Published: December 2022

Este trabajo analiza el tratamiento editorial de la usura en El Tiempo, diario católico del Porfiriato, de acuerdo con el enfoque de la nueva historia política, no como tema económico. El énfasis del trabajo recae en la redacción de los textos y las posiciones políticas de sus autores, bajo la idea de que tales textos tuvieron el propósito de desprestigiar al liberalismo y promover la alternativa católica a problemas sociales como la usura. Este es el primer estudio sobre el tema centrado en dicho periódico exclusivamente, lo que me ha permitido ahondar en el pensamiento social del catolicismo seglar antes del hito Rerum novarum. Los resultados sugieren que en esos años se desarrolló un pensamiento católico social original que invita a repensar los trabajos clásicos sobre el catolicismo en México.
¿Champotón o Potonchán?
Authors: Iturriaga José N.
Published: December 2022

Desde el siglo XVI hasta el XXI, muchos historiadores han confundido Champotón (en Campeche) con Potonchán (en Tabasco). El asunto no es menor, pues no se trata solamente de un error toponímico o silábico, sino de una confusión de lugares donde acaecieron sucesos diametralmente opuestos. Se muestra cómo el error del más afamado de los cronistas, Bernal Díaz del Castillo, pudo arrastrar a decenas de generaciones de historiadores, desde Oviedo, Torquemada, Herrera, Argensola, Cogolludo, Solís, Prescott y Orozco y Berra hasta Cunninghame, Ramírez Cabañas, Gurría Lacroix, José Luis Martínez, Juan Miralles y Christian Duverger, entre otros muchos.
Optimization of Factors that Critically Impact Time and Cost Overrun in Construction Projects
Authors: Shakya Kumar Gourav , Gupta Er. Himmi
Published: December 2022

Abstract: The current study seeks to optimize the factors impacting the time and cost overrun in construction projects. The effect of widely identified factors of cost, time, quality, productivity, client satisfaction, environment, regulatory and community satisfaction and health and safety have been considered in this study. Data on the study variables were gathered from more than seventy construction projects stakeholders such as academia, engineers, contractors, real estate developers, architects, government official etc. using a standardized questionnaire. This paper focuses on use of relative importance index and statistical technique of ANOVA hypothesis to get an optimal solution of the factors that critically impact time and cost overrun in construction projects
Optimizers in Deep Learning: A Comparative Study and Analysis
Authors: Bashetty Sujay , Raja Kalyan , Adepu Sahiti , Jain Ajeet
Published: December 2022

Abstract: Machine learning has enormously contributed towards optimization techniques with new ways for optimization algorithms. These approaches in deep learning have wide applications with resurgence of novelty starting from Stochastic Gradient Descent to convex and non-convex ones. Selecting an optimizer is a vital choice in deep learning as it determines the training speed and final performance predicted by the DL model. The complexity further increases with growing deeper due to hyper-parameter tuning and as the data sets become larger. In this work, we analyze most popular and widely optimizers algorithms empirically. The augmenting behaviors of these are tested on MNIST, Auto Encoder data sets. We compare them pointing out their similarities, differences and likelihood of their suitability for a given applications. Recent variants of optimizers are highlighted. The article focuses on their critical role and pinpoints which one would be a better option while making a trade-off.
Steady and Transient Analysis of Engine Cylinder Head with Fins at 3000C and 5000C
Authors: Kumar Raushan , Pandey Vijaykant
Published: December 2022

Abstract: The combustion chamber of a motor cycle's engine cylinder is subjected to high temperatures and thermal strains, on which fins are attached to cool the cylinder, and fins are given on the cylinder to boost the heat transfer rate. Thermal investigation of an engine block with fins was performed in this paper. The heat dissipation inside the cylinder may be determined by doing thermal analysis on cylinder block fins. The premise of cylinder block cooling is to extend the fins across the cylinder block, increasing the heat transfer rate. The engine block fins' parametric model was created in 3D software Solidworks, and thermal analysis was performed on the fins with grooves and fins without grooves with and without the block to determine temperature variation in transient and steady states, that is, with and without considering over time. ANSYS software is used for thermal analysis. Analysis is also performed on other materials. In this thesis report, two models were produced in software, and amended designs of the same model were studied, as well as a comparison of two models based on geometry and material.
Wi-Fi Technology
Authors: Ghadage Shivani , Joshi Swapnali , Thorat Shweta
Published: December 2022

Abstract: Technology is making rapid progress and is making many things easier. As the innovative thinking of persons is increasing day-by-day, new methods for wireless networking has been evolved of which our Wi-Fi, (Wireless Fidelity) is a trademark that belongs to the Wi-Fi Alliance. It is name commonly used for the standard of wireless (radio) connection that integrates several protocols and is based on a family of IEEE 802.11 standards (Institute of Electrical and Electronic Engineers is an international organization dedicated to the development of standards in electronic technology). The most famous and the most common today is IEEE 802.11g protocol, which determines the operation of wireless networks. Install Wireless LAN was recommended where the deployment of cable system was Wi-Fi, an acronym for Wireless-Fidelity which is the wireless way to handle networking. The main aim of this paper is wireless networking achieved by Wi-Fi. This paper introduces Wi-Fi technology and states the history of this technology in brief. We then deal with the different ways of wireless networking, connecting wi-fi and with wi-fi security. This paper concludes with the pros and cons of this technology and it’s future.
Maqasid Shariah perspective on Indonesia's winning strategy of paper dumping lawsuit on WTO
Authors: Sa'diyah Chalimatus
Published: December 2022

In the last eight years, Indonesia has extensive forests as paper raw materials and has experienced three accusations of paper dumping practices in foreign trade or exports. The allegation of dumping practices addressed to Indonesia was submitted to the WTO as the institution that oversees all trade issues between countries in the form of filing a case or trade lawsuit. Three lawsuits from Pakistan, South Korea, and Australia over allegations of paper dumping practices at the WTO have been won by Indonesia. From an Islamic law perspective, dumping itself is prohibited if it aims to harm other countries. This article aims to provide an overview of Indonesia's paper dumping practice allegations from the perspective of Islamic law, with an explanatory and narrative approach.
The Religious Leaders' View on Deradicalization Efforts through the Islamic Educational Institutions and Anti-Terrorism Law in Yogyakarta
Authors: Saleh M Nurul Ikhsan
Published: December 2022

The government continues to carry out various de-radicalization efforts in responding to the phenomenon of terrorism and acts of religious-based extremism that have occurred in Indonesia in the last two decades. One of the deradicalization efforts is carried out through the application of the anti-terrorism law, although many parties are still debating the effectiveness of its enforcement. On the other hand, efforts to deradicalize the government through Islamic educational institutions need to be continued because this aspect is considered the most likely to moderate the understanding of the younger generation of Muslims. This study uses a qualitative approach, with a case study method that examines the views of religious leaders (lecturers and activist of Islamic religious organizations) on the role of Islamic educational institutions in Indonesia in the process of deradicalization and counter-terrorism. Clearly, this study reveals the need for the involvement of Islamic educational institutions in encouraging religious deradicalization programs, particularly on several aspects such as character building, moderate meaning of Islamic doctrine, understanding of the diversity of Islamic history and Fiqh, creation of comparative thought narratives, and taking appropriate action initiatives. good. Thus, this research concludes that the government needs to strengthen efforts to deradicalize through Islamic educational institutions and evaluate the effectiveness of implementing anti-terrorism laws.
A Comprehensive Review on Antioxidant-Rich Natural Fruit and Vegetable Products and Human Health
Authors: Nema Prakhar , Namdev Ankit , Dangi Amit , Lodhi Amit , Rohit Anjali , Vishwakarma Harshna
Published: December 2022

Antioxidants are important ingredients that are present in fruits and vegetables (FAV). With increased consumption of FAV in its raw and processed form, a predominantly plant-based diet rich in FAV could reduce the risk of the development of chronic human diseases. This review highlights the potentials of the various types of antioxidants containing FAV; their impact on human health as nutraceuticals, pharmaceuticals, and phytoceuticals; as well as prospects in tackling some chronic human diseases. The structures and activity relationship of the antioxidant compounds, as well as their mechanism of action, are examined from current scientific investigations. Information provided herein will give more insight into the roles of antioxidant ingredients present in FAV.
Keywords - Fruits; vegetables; phytochemicals; antioxidants; human health; diets
A Comprehensive Review: Transdermal Drug Delivery System: A Tool For Novel Drug Delivery System
Authors: Sadab Sadab , Sahu Sarad , Patel Shubham , Khan Rubeena , Khare Basant , Thakur Bhupendra Singh , Jain Anushree , Jain Prateek Kumar
Published: December 2022

In the recent decade, skin delivery (topical and transdermal) has gained an unprecedented popularity, especially due to increased incidences of chronic skin diseases, demand for targeted and patient compliant delivery and interest in life cycle management strategies among pharmaceutical companies. Transdermal drug delivery system was presented to overcome the difficulties of drug delivery especially oral route. Transdermal drug delivery refers to a means of delivering drugs through the surface of the skin for local or systemic treatment. The drug functions after absorption through the skin into the systemic circulation via capillary action at a certain rate. Transdermal patches are now widely used as cosmetic, topical and transdermal delivery systems. These patches represent a key outcome from the growth in skin science, technology and   expertise developed through trial and error, clinical observation and evidence-based studies that date back to the first existing human records. A transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through skin and into the bloodstream. An advantage of a transdermal drug delivery route over other types of delivery system such as oral, topical, intravenous (i.v.), intramuscular (i.m.), etc. is that the patch provides a controlled release of the medication into the patient, usually through either a porous membrane covering a reservoir of medication or through body heat melting thin layers of medication embedded in the adhesive. The main disadvantage to transdermal delivery systems stems from the fact that the skin composition offers very effective barrier that allow only small molecule based drugs to penetrate the skin and pass through the barrier. Sildenafil citrate (SLD) is a selective cyclic guanosine monophosphate-specific phosphodiesterase type 5 inhibitor used for the oral treatment of erectile dysfunction and more recently, it has been used for the treatment of pulmonary arterial hypertension and the enhancement of uteroplacental perfusion in case of fetal growth retardation. The challenges facing the oral administration of the drug include poor bioavailability and short duration of action that requires frequent administration. The main objective of transdermal drug delivery system is to deliver drugs into systemic circulation through skin at predetermined rate with minimal inter and intrapatient variations.
Keyword: Skin delivery, Transdermal drug delivery, Oral rout, Sildenafil citrate, Pulmonary arterial hypertension
Review on QSAR using Anticancer Drug
Authors: Ahirwar Hemant , Kurmi Gabbar , Khan Rubeena , Khare Basant , Jain Anushree , Jain Prateek Kumar , Thakur Bhupendra Singh
Published: December 2022

New drug discovery has been acknowledged as a complicated, expensive, time-consuming, and challenging project. It has been estimated that around 12 years and 2.7 billion USD, on average, are demanded for a new drug discovery via traditional drug development pipeline. How to reduce the research cost and speed up the development process of new drug discovery has become a challenging, urgent question for the pharmaceutical industry. Computer-aided drug discovery (CADD) has emerged as a powerful and promising technology for faster, cheaper and more effective drug design. Recently, the rapid growth of computational tools for drug discovery, including anticancer therapies, has exhibited a significant and outstanding impact on anticancer drug design, and has also provided fruitful insights into the area of cancer therapy. In this work, we discussed the Qualitative structure activity relationship, a computer-aided drug discovery process with a focus on anticancer drugs.
Keywords: New drug discovery, Computer-aided drug discovery, the Qualitative structure activity relationship, Anticancer
Educación para Jóvenes y Adultos. Compromiso social postergado por la Formación Inicial Docente
Authors: González Campos José , Medina Pérez Jessica , González Rojas Elizabeth , Silva Santander Micheline , Pozo Jaña Francisco
Published: December 2022

La última encuesta Casen aplicada en Chile muestra cifras alarmantes de deserción escolar, cerca de 5 millones de estudiantes entre 14 y 17 años han abandonado sus estudios. Son estos jóvenes quienes necesitan de una Educación para Personas Jóvenes y Adultas (EPJA) fortalecida y con la capacidad de ofrecerles oportunidades de finalizar con su educación formal. Esta investigación es de carácter cuantitativo, descriptivo e inferencial, que tiene por objetivo conocer el grado de contribución de la Formación Inicial Docente desde la perspectiva de los estudiantes en formación, mediante un cuestionario estructurado en tres dimensiones. Los resultados de esta investigación señalan conocimientos en el área de medio a nulo, prejuicios atribuidos a los estudiantes que asisten a estos establecimientos, bajas expectativas laborales en el área y menor preparación dependiendo de la carrera.
Analisis Karakter Cinta Tanah Air Melalui Novel Berjudul "Hatta: Aku Datang Karena Sejarah
Authors: Azizah Ifah , Wahyuni Anny , Purnomo Budi
Published: December 2022

Mohammad Hatta merupakan seorang tokoh penting bagi kemerdekaan Indonesia. Peran dan pemikiran Mohammad Hatta adalah salah satu yang paling melekat dari pemimpin bangsa Indonesia lainnya, baik dibidang sosial, politik maupun ekonomiMohammad Hatta adalah seorang tokoh pergerkan nasional indonesia yang memiliki pengetahuan luas di bidang sosial, politik, dan ekonomi Indonesia. Nasionalisme Mohammad Hatta yaitu berdasarkan konsep kedaulatan rakyat memiliki arti, yaitu kekuasaan tertinggi di tangan rakyat, dan dilaksanakan dikendalikan oleh dewan yang dipilih oleh rakyat, demi rakyat, Konsep kedaulatan memiliki poin-poin demokrasi di bidang politik dan ekonomi. Aktualisasi Mohammad Hatta pandangan kebangsaan yang tertuang dalam pasal-pasal UUD 1945 dan asas-asasnya Pancasila yang memuat ketetapan nilai ketuhanan sebagai landasan moral Indonesia. nilai-nilai kemanusiaan, nasionalisme berbagai aliran, cita-cita keadilan filosofis, politik dan sosial untuk kesejahteraan rakyat.

Penelitian ini adalah penelitian kualitatif dengan menggunakan metode history atau metode sejarah dengan pendekatan studi pustaka, penelitian ini bertujuan untuk menganalisis karakter cintah tanah air melalui novel yang berjudul “Hatta: Aku Datang Karena Sejarah”
Análisis de nicho ecológico de Amazona auropalliata (Psittaciformes: Psittacidae) y Quiscalus mexicanus (Passeriformes: Icteridae) en Costa Rica
Authors: Martínez-Urbina Jamie
Published: December 2022

Se analizaron bases de datos de observaciones humanas de las especies Amazona auropalliata (amazona nuca amarilla) y Quiscalus mexicanus (zanate) en el territorio costarricense, como área de interés, así se conoció el patrón de distribución geográfica y su influencia en el solapamiento de nicho de ambas especies. Se usaron 20 variables bioclimáticas y, mediante el programa RStudio, se conocieron las correlaciones principales entre todas las variables para cada una de las especies del estudio. La especie invasora Quiscalus mexicanus muestra una amplia expansión de distribución geográfica ya que puede adaptarse a zonas de gran perturbación ambiental ocasionada por los seres humanos, tal como la urbanización o las actividades agrícolas, además tolera los cambios climáticos, mientras que la Amazona auropalliata tiene una distribución restringida de acuerdo con su alimentación y anidación. Por tanto, se puede intuir que la especie invasora podría influir en la disminución de las poblaciones de Amazona auropalliata, la cual es encuentra en peligro de extinción de acuerdo con la IUCN (2020).
Testing hypotheses about the evolution of parental care and in ray-finned fishes
Authors: Crespo Ana , Robalo Joana
Published: December 2022

Actinopterygian fishes (subclass Actinopterygii) display considerable
diversity regarding forms of parental behaviors and types of carer sex.
Contrary to caregiver sex, parental behaviors were not traced at the
subclass level. In order to understand the evolutionary history of
parental care in the ray-finned fishes, parental care states were mapped
upon an existing supertree using parsimony ancestral state
reconstruction. We investigated the evolution of substrate guarding,
mouthbrooding, external egg carrying and internal gestation. We aimed to
test the general hypothesis, according to which, more advanced forms of
care were always preceded by simpler ones. We show that, in this
subclass, parental care traits evolved from ancestors devoid of parental
care. The transition from the ancestral state of no care to substrate
guarding was the most frequent, whereas the other transitions recorded
low scores. The data supported the evolution of mouthbrooding from
substrate guarding, whilst external egg carrying arose from both
substrate guarding and the ancestral state, which might suggest
independent evolutionary routes of external egg carrying. Consequently,
our results did not fully corroborate the general hypothesis mentioned
above. Internal gestation evolved both in clades devoid of parental care
and in clades descendant from substrate guarders ancestors.
An integrated bioprocess for engineering of human dental pulp stem cell-alginate-based bone fillers
Authors: Zamorano Mauricio , Mantalaris Athanasios
Published: December 2022

Background Bone tissue engineering emerged as a practical
approach to tackle the prosthetic industry limitations. Merging aspects
from developmental biology, engineering and medicine with the aim to
produce fully-functional bone tissue. Mesenchymal stem cells (MSCs)
harbor the capability of self-renewal and specific lineage
differentiation. Herein lies their potential for bone tissue
engineering. Among MSCs, human dental pulp stem cells (hDPSCs) lodge
higher proliferation rate, shorter doubling times, lower cellular
senescence, and enhanced osteogenesis than hBM-SCs. In addition, these
cells have ease in access and a subtle extraction procedure. Thus,
harbouring fewer moral concerns than most MSCs available and embodying a
promising cell source for BTE therapies able to replace hBM-MSCs.
Interestingly, their study has been limited. Conversely, there is a need
for their further study to harness their BTE true value, with special
emphasis in the design of bioprocesses able to produce viable,
homogenous bone constructs in a clinical scale. Methods Here,
we study the in vitro osteogenic differentiation of hDPSCs
encapsulated in alginate hydrogels under suspended culture in a novel
and scalable perfusion bioreactor, establishing culture conditions; and
compare it with three-dimensional (3D) static and fed-batch culture.
Results hDPSC-based bone-like constructs produced in the novel
system performed above the compared culture strategies, displaying
higher alkaline phosphatase activity, more homogeneous, denser and
functional bone constructs. In addition, cell constructs produced by the
in-house designed system were richer in mature osteoblasts.
Conclusion This study reports the development of a novel
bioprocess able to produce hDPSC-alginate-based bone-like constructs to
be used as bone fillers, while providing new insights into hDPSCs
therapeutic potential and a system able to be transferred from the
laboratory bench into medical facilities.
Shortening the Biologics Clinical Timeline with a Novel Method for Generating Stable, High Producing Cell Pools and Clones
Authors: Hall Chad A. , Kravitz Rachel H. , Johnson Karl F. , Sanek Nicholas A. , Maiti Payel , Ziemba Keith R. , Liu Jia , Andreev Dmitri O. , Chrostowski Victoria L. , Collins Ian J. , Bleck Gregory
Published: December 2022

Reducing drug development timelines is an industry-wide goal to bring
medicines to patients in need more quickly. This was exemplified in the
COVID-19 pandemic where reducing development timelines had a direct
impact on the number of lives lost to the disease. The use of drug
substance produced using cell pools, as opposed to clones, has the
potential to shorten development timelines. Toward this goal, we have
developed a novel technology, GPEx® Lightning, that allows for rapid,
reproducible, targeted recombination of transgenes into more than 200
Dock sites in the CHO genome. This allows for rapid production of high
expressing stable cell pools and clones that reach titers of 4 to 12 g/L
in generic fed-batch production. These pools and clones are highly
stable in both titer and glycosylation, showing strong similarity in
glycosylation profiles.
The Fengyun-4B Digital Fluxgate Magnetometer
Authors: Weng Chenghan , Zhou Bin , Xue Yongliang , Tong Yuqi , Cheng Bingjun , Zhang Yiteng , Wang Jingdong , Li Lei , Zhang Xin , Zhang Ruyi , Zhang Liguo , Guo Jianguang , Zong Weiguo , Chen Bo , Zhang Xiaoxin , Wang Jingsong
Published: December 2022

This paper describes the development of the fluxgate magnetometer on the
Fengyun-4B satellite. The Fengyun-4 is the second generation of China’s
geostationary orbit satellite with the function of monitoring the space
environment in GEO orbit. A fluxgate magnetometer (FGM) is deployed on
this satellite to observe the magnetic field as a necessary input to
space weather forecasting. This payload adopts three 3-axis fluxgate
sensors to obtain space magnetic field data by excluding the satellite’s
interference. Each three-axis fluxgate sensor has an independent signal
processing circuit. FGM uses digital signal processing technology to
acquire magnetic field signals. First, the analog signal is oversampled
using a high-speed ADC, then digital signal processing, such as
phase-sensitive demodulation, integration, and filtering, is performed
inside the FPGA, and the feedback signal is output to the feedback coil
through the DAC. This signal processing loop constitutes an ADC system,
and the quantization accuracy of the output digital quantity can reach
18 bits. the FGM performs in-orbit calibration during satellite rotation
maneuver and Alfven wave events. Comparison with the GOES-16 satellite
and Tsyganenko magnetic field model proves FGM to be effective in
monitoring the magnetic field of the space environment. Through joint
observations with GOES-16 satellite and geomagnetic stations, FY-4B
describes the development of a typical magnetic storm on November 4,
2021. The Ground calibration and in-orbit preliminary results show the
FY-4B satellite magnetometer outputs 20 bits of digital resolution data
at a 30 Hz sampling rate, with the noise lower than 3×10-4nT2/Hz@1Hz in
the ±600nT range.
Topic Modeling Using Latent Dirichlet Allocation & Multinomial Logistic Regression
Authors:   Department of Computer Science University of Port Harcourt Choba-Port Harcourt, Nigeria, Obiorah , Philip , Onuodu Friday , Eke Batholowmeo
Published: December 2022

Unsupervised categorization for datasets has benefits, but not without a few difficulties. Unsupervised algorithms cluster groups of documents in an unsupervised fashion, and often output findings as vectors containing distributions of words clustered according to their probability of occurring together. Additionally, this technique requires human or domain expert interpretation in order to correctly identify clusters of words as belonging to a certain topic. We propose combining Latent Dirichlet Allocation (LDA) with multi-class Logistic Regression for topic modelling as a multi-step classification process in order to extract and classify topics from unseen texts without relying on human labelling or domain expert interpretation in order to correctly identify clusters of words as belonging to a certain topic. The findings suggest that the two procedures were complementary in terms of identifying textual subjects and overcoming the difficulty of comprehending the array of topics from the output of LDA. Keywords: Natural Language Processing; Topic Modeling; Latent Dirichlet Allocation; Logistic Regression
Instrumen Keterampilan Membaca Permulaan Anak Kelompok B
Authors: Safira Isna , Widiana I Wayan , Astawan I Gede
Published: December 2022

Keterampilan membaca permulaan adalah kemampuan dalam mengenal lambang-lambang huruf, bunyi huruf, dan mampu mengubungkannya menjadi sebuah kata. Membaca permulaan ditujukan kepada anak usia dini untuk mempersiapkan keterampilan membaca anak sebelum memasuki sekolah dasar. Peserta didik di sekolah yang mengalami kesulitan dalam merangkai huruf, peserta didik belum mampu mengenal huruf dan merangkainya menjadi kata. Dalam pembelajaran membaca anak usia dini diperlukan motivasi, dorongan serta latihan-latihan untuk mengembangkan keterampilan membaca anak. Selain itu, cara guru mengajar, prosedur maupun instrumen yang digunakan juga mempengaruhi peningkatan kemampuan anak dalam membaca permulaan. Maka dari itu, peneliti melakukan penelitian yang ertujuan untuk menghasilkan instrumen penilaian keterampilan membaca permulaan anak kelompok B yang valid dan reliabel. Model pengembangan yang digunakan adalah model R&D yang dikembangkan oleh Borg and Gall melalui tahap research and development. Instrumen keterampilan membaca permulaan anak kelompok B Taman Kanak-Kanak Aisyiah Bustanul Athfal klungkung merupakan subjek penelitian dengan menyertakan kisi-kisi serta mengembangkan kedalam kuisioner dengan 12 butir pernyataan telah diuji oleh ahli/pakar pada bidangnya sehingga validitas dan reliabilitas suatu instrument dapat terpenuhi. Instrument yang digunakan memiliki validitas dan reliabilitas yang sangat tinggi dengan skor 0,84 dan 0,81. Hasil tersebut mengindikasikan bahwa instrument yang telah dikembangkan dapat diterapkan dan digunakan sebagai mana mestinya dalam proses pembelajaran.