bluuebunny/crossref_metadata_2025 huggingface dataset:
Quality of Life and Glucose Control After 1 Year of Nationwide Reimbursement of Intermittently Scanned Continuous Glucose Monitoring in Adults Living With Type 1 Diabetes (FUTURE): A Prospective Observational Real-World Cohort Study
Authors: Charleer Sara , De Block Christophe , Van Huffel Liesbeth , Broos Ben , Fieuws Steffen , Nobels Frank , Mathieu Chantal , Gillard Pieter
Published: December 2019

OBJECTIVE

In 2016, nationwide reimbursement of intermittently scanned continuous glucose monitoring (isCGM) for people living with type 1 diabetes treated in specialist diabetes centers was introduced in Belgium. We undertook a 12-month prospective observational multicenter real-world study to investigate impact of isCGM on quality of life and glycemic control.

RESEARCH DESIGN AND METHODS

Between July 2016 and July 2018, 1,913 adults with type 1 diabetes were consecutively recruited in three specialist diabetes centers. Demographic, metabolic, and quality of life data were collected at baseline, 6 months, and 12 months of standardized clinical follow-up. The primary end point was evolution of quality of life from baseline to 12 months. Secondary outcome measures were, among others, change in HbA1c, time spent in different glycemic ranges, occurrence of acute diabetes complications, and work absenteeism.

RESULTS

General and diabetes-specific quality of life was high at baseline and remained stable, whereas treatment satisfaction improved (P < 0.0001). Admissions for severe hypoglycemia and/or ketoacidosis were rare in the year before study (n = 63 out of 1,913; 3.3%), but decreased further to 2.2% (n = 37 out of 1,711; P = 0.031). During the study, fewer people reported severe hypoglycemic events (n = 280 out of 1,913 [14.6%] vs. n = 134 out of 1,711 [7.8%]; P < 0.0001) or hypoglycemic comas (n = 52 out of 1,913 [2.7%] vs. n = 18 out of 1,711 [1.1%]; P = 0.001) while maintaining HbA1c levels. Fewer people were absent from work (n = 111 out of 1,913 [5.8%] vs. n = 49 out of 1,711 [2.9%]; P < 0.0001). Time spent in hypoglycemia significantly decreased in parallel with less time in range and more time in hyperglycemia. Eleven percent (n = 210) of participants experienced skin reactions, leading to stopping of isCGM in 22 participants (1%).

CONCLUSIONS

Nationwide unrestricted reimbursement of isCGM in people with type 1 diabetes treated in specialist diabetes centers results in higher treatment satisfaction, less severe hypoglycemia, and less work absenteeism, while maintaining quality of life and HbA1c.
Rapid fabrication of precise glass axicon arrays by an all laser-based manufacturing technology
Authors: Schwarz Simon , Rung Stefan , Esen Cemal , Hellmann Ralf
Published: December 2019

The authors report on the rapid fabrication of an axicon array, consisting of 37 individual axicons in a hexagonal arrangement, made of fused silica by an all laser-based manufacturing method within only 23 min. Therefore, a two-step process is used, first to ablate the silica substrate in a layer-by-layer process, generating the predefined geometry of the axicon array with a femtosecond laser, and second to polish the rough optical element by applying a CO2 laser to reach smooth surfaces. Here, the roughness is reduced from 0.36 μm before to 48 nm after the polishing step, thus reaching optical quality. The finalized axicon array was placed into a femtosecond laser machine for a detailed evaluation of the resulting quasi-Bessel beams. It is found that all sub-beams exhibit the typical zeroth-order Bessel beam intensity distribution, in turn confirming that the manufacturing process used here is well suitable for the fabrication of complex optical geometries. Cross sections of the sub-beams in both x- and y-directions show an almost identical intensity profile, indicating the high contour accuracy of the axicon array. The diameter of the quasi-Bessel beams is measured to be in the range of 9.4–10.3 μm [full width at half-maximum (FWHM)], and the Bessel range in propagation direction amounts to between 8.0 mm and 8.5 mm (FWHM).
TEOLOGIA PARA A PAZ: A RESPONSABILIDADE DAS RELIGIÕES NOS CONFLITOS À LUZ DA OBRA “GUERRA E PAZ”, LIEV TOLSTÓI.
Authors: Gonçalves José Diógenes Dias
Published: December 2019

O presente trabalho é uma reflexão do potencial de paz da teologia na obra Guerra e Paz. A convergência dos discursos das religiões a favor da paz contrasta com a sua presença no centro dos grandes conflitos mundiais.  Cabe perguntar se as declarações pacifistas das autoridades e dos fiéis se limitam ao discurso. Porém, se realmente a intenção existe, como se efetiva a redução de conflitos com a intervenção das religiões?  O clássico russo Guerra e Paz é o eixo do argumento. À primeira vista a obra é uma odisseia de guerra, porém, trata-se da celebração de paz, fruto do empenho pela verdade e pela bondade na humanidade.  Qual seria a responsabilidade dos teólogos, religiosos e seus líderes neste esforço?  Trata-se de uma pesquisa bibliográfica que objetiva apresentar a contribuição efetiva que as comunidades religiosas possuem em evitar ou diminuir as crises.  A combinação dos conceitos Religião e Conflito possui mais espaço midiático que Religião e Paz; pouco destaque é dado ao aspecto positivo. Possivelmente, o incremento de parcerias da sociedade civil com as comunidades religiosas possa mudar este quadro; inobstante a crescente pluralização e o aumento da secularização, o resultado é a paz em destaque ao invés da guerra.
RELIGIOSIDADE, LINGUAGEM E SIGNIFICAÇÃO: CONSIDERAÇÕES SOBRE OS ASPECTOS RELIGIOSOS PRESENTES NA CAPA DO ROMANCE GRÁFICO REINO DO AMANHÃ
Authors: Cruz Anderson Luciano , Cruz Paulo Henrique Pinheiro Barbosa
Published: December 2019

Resumo: O romance gráfico Reino do Amanhã, de Mark Waid e Alex Ross, publicada inicialmente em 1996, destaca-se entre as histórias em quadrinhos, sobretudo por sua intertextualidade com o Livro do Apocalipse. Entretanto, para além do texto escrito, as imagens que compõem a obra apresentam signos notadamente religiosos que evidenciam-se como importante fonte de estudo acerca da religiosidade que, em larga medida, inspira a produção da HQ. A análise dessa fonte convida a um esforço de abordagem interdisciplinar, que em muito enriquece a investigação científica dos temas caros à religião. Desta feita, o artigo tem por objetivo refletir sobre os aspectos religiosos presentes na composição visual da capa do romance gráfico Reino do Amanhã. Considerando as histórias em quadrinhos como paraliteratura de grande relevância na chamada cultura pop e com base nos elementos de análise propostos pela Gramática do Design Visual, argumenta-se sobre a religiosidade presente na ilustração de Alex Ross.
From Secrecy to Pride
Authors: Pohtinen Johanna
Published: December 2019

In this article, I discuss how the kink identity is constructed in a society where kink is defined as non-normative and stigmatised. I do this through an af- fective reading of my research material: autobiographical writings by kinky identified individuals. By looking at the affects, I have been able to recognize those elements that are integral to the kink experience. Affective states, such as fear of being found out, frustration, loneliness, hope, and excitement were expressed in the writings. Kink is negotiated with regard to normativity and stigma through mechanisms which may produce behaviour such as staying in the closet and secrecy about the individual’s kinky desires. Due to the stigma, people may even denounce their own preferences as wrong and unacceptable, and accepting one’s kinkiness may be described as a journey requiring cour- age. Kink communities function as safer spaces for the kinky, where the neg- ative experiences and affects may even turn into kinky pride. Furthermore, the secrecy and the fear of being found out may also function as the very fas- cinations of kink. To further highlight the affective states regarding kink, I employ a method of ethnographic fiction that is based on my own embodied and affective knowledge of kink.
The Endangered Coastal Fishers along the Coast of the Archipelago Sea
Authors: Sonck-Rautio Kirsi
Published: December 2019

The small-scale fisheries of the Finnish archipelago are in crisis. Three major problems were identified during an ethnographic study of the different stake- holders in the fishing sector: the grey seal, the great cormorant, and regulation of pikeperch harvesting. Within the framework of political ecology, develop- ments in the current state of the fisheries are examined and the policy-mak- ing processes are analysed. Additionally, the notion of knowledge and the role of both scientific knowledge and local ecological knowledge in the context of fisheries management and fisheries management science are discussed.
In this Issue
Authors: Briggs David
Published: December 2019

In this issue continues to explore the theme of health reform by traversing some recent experiences of the Editor in rural health contexts that traverse big data, technology, the social capital of health professionals all currently operating in drought and fire ravaged circumstances. After we pass the current circumstances there will be a need to rebuild rural communities and sustainable health services and workforce should be part of the community building......
Hematological parameters of carp juveniles in terms of introducing Quercus cortex extract into diet
Authors: Miroshnikova Elena Petrovna , Kilyakova Julia Vladimirovna , Ponomarev Sergey Vladimirovich , Arinzhanov Azamat Ersainovich , Miroshnikova Maria Sergeevna
Published: December 2019

The article presents the results of studies of morphological and biochemical blood parameters of carp juveniles when adding the extract Quercus cortex (1, 2, 3 mg/kg of feed), probiotic preparation of Soya-bifidum (0.7 ml/kg of feed), antibiotics Ciprofloxacin hydrochloride in the composition of the drug Antibak 250 (100 mg/kg of feed). Analysis of hematological parameters of carp juveniles showed that adding Quercus cortex extract to the diet at a dosage of 2 mg/kg of feed contributed to increasing SGE by 66%, the average concentration of hemoglobin in the red blood cell by 20% compared to the control group. An increase in the level of leukocytes compared to the control was recorded only in the IV experimental group and made 13% (P≤0.05). An increase in glucose in the groups receiving Quercus cortex extract has been stated: in the I experimental group- by 4.2 times (P≤0.001), in II – by 3.4 (P≤0.001) and in III – by 3.3 (P≤0.001) compared to the control. Increasing glucose concentration indicates active metabolic processes and better stress resistance in the fish body. Iron content in carp blood was higher only in the first experimental group (by 3 times) compared to the control. Increasing activity of alanine aminotransferase was observed in all experimental groups, the highest rate of this enzyme being recorded in the IV experimental group (feed with probiotic additive Soya-bifidum) with a significant excess of control by 48%. Lactate dehydrogenase enzyme activity exceeded the control in all experimental groups, maximum increase (by 67%) was observed in the IV experimental group. Alkaline phosphatase was below the control in all experimental groups, minimum values being registered in the IV experimental group- by 37% less than the control. Indicators of p-amylase in the IV group exceeded the control by 2.6 times, in the V group – by 1.5 times. In the II group p-amylase was lower than the control by 44%, and in the III – by 1.9 times. According to the obtained hematological data, it has been established that including Quercus cortex extract into the diet of carp juveniles is promising due

to the positive effect on the fish physiological status, immune status, metabolic processes, hematopoiesis and digestibility of feed.
Ecological valency of North-Caspian mysids and Quma cranious to oxygen
Authors: Degtyareva Larisa Vyacheslavna , Dairova Dinara Srurovna , Kostrykina Tatiana Aleksandrovna , Pismennaya Olga Aleksandrovna , Kashin Dmitry Vladimirovich
Published: December 2019

The paper focuses on the problems of violation of the ecological balance, changes in the nutrient load, undermining the ecosystem’s biopotential, caused by anthropological pressure and resulting in deterioration of the oxygen regime in the bottom layer of water. The purpose of the research was to determine the environmental oxygen tolerance in bottom invertebrates, representatives of the orders Mysidacea and Cumacea, which are forage objects for beluga, sturgeon, stellate sturgeon, bream and pike perch. The research was conducted in 2013-2017 in the western part of the North Caspian. Developing of oxygen deficiency in the studied water area was due to thermohaline stratification of water masses. Hypoxia was formed in local areas. Representatives of Mysidacea predominantly inhabiting the bottom layers have a low frequency of occurrence, because they live in a narrow range of oxygen content (about 5-7 mg/l). A low oxygen concentration (less than 3.95 ml/l (74%)) inhibits the development of Mysidacea. Paramysis ullskyi prevailed in the total number of samples taken from macrozoobenthos, and Paramysis lacustris prevailed in the total biomass. Limnomysis benedeni and Paramysis ullskyi were the most resistant to oxygen deficiency. These species have a maximum ecological valence to oxygen. Representatives of the order Cumacea are characterized by a high frequency of occurrence. The species Schizorhynchus bilamellatus dominated in the surveyed water area, both in abundance and biomass. Cumacea live in a wide variability of oxygen content. Schizorhynchus bilamellatus and Stenocuma graciloides are most resistant to oxygen deficiency. These species have a maximum ecological valence to oxygen. The minimum oxygen recorded over the entire research period (1.29 ml/l; 21%) is not critical for Stenocuma graciloides. The results of the study are of practical value for assessing the condition of the food supply of benthos-eating fish that are commercialized in the western part of the North Caspian
Daily dynamics of vertical distribution and amount of sturgeons in riverbed depression in summer-autumn period
Authors: Aldokhin Andrey Stepanovich , Chemagin Andrey Aleksandrovich
Published: December 2019

The article presents the results of studying the fish distribution in the water column of the riverbed depression using remote echometric sounding with a software-hardware acoustic system with a vertical view. The study was conducted in the lower reaches of the Irtysh River. In the appointed period (July-October) under a decrease in the level regime and water temperature the increasing density of fish in the water area of the riverbed depression is explained by fish gathering in the period preceding wintering. The share of sturgeons varied from 5.46 to 10.28% of the total fish density, the indicators of which were in the range 1.70-5.05 thousand sp/ha in the daytime, 2.78-6.77 thousand sp/ha in the night. There has been stated the daily vertical migration of sturgeons, which is more uniform throughout the water column in the night, including the near-surface and near-bottom water horizons. In the dark near-surface water horizons are most intensively explored by large fish (25-30, 30-35, > 35 cm). The trigger of the daily vertical migration of sturgeons is supposed to be the light brightness, despite the poor eyesight of the fish under study, i.e. changing vertical position of sturgeons occurs due to endogenous circadian rhythms, as in many hydrobionts. The recorded features of sturgeon distribution because of preference of the direction and intensity of various factors can contribute to the optimization of bioenergy losses in hard turbulent conditions of riverbed depressions.
Avcı Akar, Amblyseius swirskii Athias-Henriot (Swirski ve Amitai 1982)’nin Biber Seralarında Üretici Koşullarında Çiçek tripsi, Frankliniella occidentalis (Pergande) (Thysanoptera: Thripidae)’e Karşı Kullanımı
Authors: KÜTÜK Halil
Published: December 2019

Çiçek thripsi, Frankliniella
occidentalis (Pergande) (Thysanoptera: Thripidae) seralarda
yetiştirilen ürünlerde ekonomik verim kaybına sebep olan en önemli
zararlılarından birisidir. Ülkemizde bu zararlıya karşı yaygın biçimde kimyasal
mücadele uygulanmaktadır. Anavatanı Akdeniz Havzası ülkelerden ve bazı
biyolojik mücadele firmaları tarafından temin edilebilen avcı akar, Amblyseius swirskii Athias-Henriot
(Swirski ve Amitai 1982) (Acari: Phytoseiidae)’nin biber seralarında thrips
kontrolünde etkili olduğu bilinmektedir. Yürütülen bu çalışmada avcı akarın,
thrips üzerindeki etkinliği üretici koşullarında Tarsus / Mersin de don
beklenen günlerde ısıtılan serada denenmiştir. Seranın deneme için ayrılan
kısmı (300 m2) bitki boyuna ulaşan yükseklikte tül kullanılarak üç
bölüme ayrılmıştır. Seranın geri kalan bölümü üreticinin kendi uygulamasına
bırakılmış ve bu kısım denemenin ilaçlı kontrol bölümü olarak
değerlendirilmiştir. Deneme için ayrılan bölüme ilaçsız kontrol ve iki farklı
salım metodu olan deneme karakterleri yerleştirilmiştir. Salım için ayrılan iki
bölüme 50 A. swirskii birey m-2
oranında avcı akar salımı gerçekleştirilmiştir. Avcı akarın salım yapıldığı
bölümün birine avcı akar salınmadan 2 saat önce 5 kg/ha dozunda çam poleni
püskürtülmüştür.  Avcı akarın salımından
bir hafta sonra başlayarak deneme parsellerinde haftada bir kez olmak üzere
thrips ve avcı akarın populasyonunu takip etmek amacıyla her bölümden 50 adet
yaprak ve 25 adet çiçek kopartılarak laboratuara getirilerek binoküler altında
görülen F. occidentalis ve A. swirskii’nin tüm dönemleri
kaydedilmiştir. Üretici koşullarında biber serasında thrips’e karşı avcı akar, A. swirskii’nin etkili olduğu ortaya
konmuştur. Sonuç olarak biber serasında A.
swirskii kullanımının ülke genelinde yaygınlaştırılması için yayım
çalışmalarının yürütülmesi gerektiği kanaatine varılmıştır.
The Effects of Trunk Shape and Shoot Distance to Trunk on The Pomological Characteristics of Hayvard Kiwifruit
Authors: ÖGE ALTUN Pınar , ÖZCAN Muharrem
Published: December 2019

In this study, different trunk shapes and distance of shoots
to trunk in kiwifruit vine on fruit characteristics were determined. The
effects of distance of shoots to the trunk on fruit quality parameters of
kiwifruit vine have different trunk shape (upright and unshaped) were
investigated in two different commercial kiwifruit orchards (well-cared and
uncared). Three branches for each kiwifruit vine were selected in terms of
distance of branches to trunk (near to trunk: ~20 cm (NT), medium distance to
trunk: ~40 cm (MT) and far to trunk: ~60 cm (FT)). It depends on the study
years fruit number (10.00-48.80), fruit diameter (5.07-6.12 cm), fruit length
(6.41-7.70 cm), fruit weight (91.73-142.06 g), fruit flesh firmness (5.20-7.55
kg), TSS amount in harvest maturity (14.35-16.37%), TSS amount in ripening
(6.80-12.00%), TA in harvest maturity (1.24-1.85%) and TA in ripening varied.
As a result, trunk shape (upright and unshaped) was found to affect fruit
quality parameters in order that upright trunk shape should be formed for fruit
quality and convenience in cultural applications.
Rhizoctonia Ağ Yanıklığı Hastalığına Karşı Bazı Fasulye Çeşitlerinin Reaksiyonları
Authors: PALACIOĞLU Gülsüm , BAYRAKTAR Harun , ÖZER Göksel
Published: December 2019

Rhizoctonia
solani fasulye üretim alanlarında yaygın olarak görülen
ve ağ yanıklığı, kök ve hipokotil çürüklüğüne sebep olarak önemli ekonomik
kayıplar oluşturan bir hastalık etmenidir. Bu çalışma kapsamında Rhizoctonia ağ
yanıklığı hastalığına karşı ülkemizde yaygın olarak yetiştirilen 30 fasulye
çeşidinin hastalık reaksiyonları yaprak inokulasyon yöntemi ile
değerlendirilmiştir. Patojen izolatı PCR-RFLP yöntemi ile R. solani AG-4 HG II olarak sınıflandırılmıştır. Çalışma kapsamında
değerlendirilen fasulye çeşitlerinin hiçbiri hastalığa tam dayanıklı değil iken
13 çeşit orta dayanıklı, 17 çeşit ise hassas olarak değerlendirilmiştir. Test
edilen çeşitler arasında en dayanıklı çeşit 40 günlük fasulye çeşidi olup bunu
Java ve Klas fasulye çeşitleri takip etmiştir.
Tohum Tipi Kinoa (Chenopodium quinoa Willd.) Hatlarının Geliştirilmesi için Seleksiyon Çalışmaları
Authors: ÇAKMAKÇI Selma , TEMEL Süleyman
Published: December 2019

Bu çalışma, bölge verim denemelerinde kullanılmak üzere standart çeşitlerden daha üstün özellik gösteren kinoa (Chenopodium quinoa Willd.) hatlarının belirlenmesi amacıyla 2017 yılında yürütülmüştür. Araştırmada önceki yıllarda seçilerek 3. kademeye getirilmiş 20 hat ve introdüksiyon yöntemi ile temin edilen 10 standart çeşit kullanılarak toplamda 30 genotip kullanılmıştır. Deneme Iğdır Üniversitesi'ne bağlı Tarımsal Uygulama ve Araştırma Merkez Müdürlüğü sahasında Augmented Deneme Desenine göre dört tekerrürlü olarak kurulmuştur. Her bir blokta 10 tane standart çeşit (Moqu Arrochilla, Oro de Valle, Populasyon Çin, French Vanilla, Mint Vanilla, Cherry Vanilla, Read Head, Sandoval Mix, Titicaca, Rainbow) ve 5 tane hat olacak şekilde toplam 15 genotip yer almıştır. Hatlardan elde edilen sonuçlara göre en düşük ve en yüksek değerler; yetişme süresi 142.6-161.9 gün, bitki boyu 112.0-187.4 cm, bitki başına salkım boyu 24.5-38.1 cm, bitki başına tohum verimi 8.16-72.97 g, bitki başına sap verimi 20.24-93.30 g, bitki başına biyolojik verim 34.32-146.63 g, hasat indeksi %25.27-%58.91, bin dane ağırlığı 1.95-2.77 g ve tohumda HP oranı %11.25-%17.10 aralığında değişim göstermiştir. Bu sonuçlara göre SÇT 16 ve SÇT 3 numaralı hatların en fazla bitki başına tohum verimi veren Moqu Arrochilla çeşidinden (47.65 g) daha yüksek bir tohum verimine sahip olduğu ve bölge verim denemelerinde kullanılabileceği saptanmıştır.
Erzurum İli Narman İlçesi Süt Sığırcılığı İşletmelerinde Kolostrum Kullanım Alışkanlıkları Üzerine Bir Araştırma
Authors: TUNÇ Muhammet Ali
Published: December 2019

Bu çalışma Erzurum İli Narman İlçesinde faaliyet gösteren sığırcılık işletmelerinin kolostrum kullanım alışkanlıklarını ve uygulamadaki yanlışlıklarını ortaya koymak amacıyla yapılmıştır. Bu amaçla 20 baş ve daha fazla süt sığırına sahip 175 işletmeden elde edilen veriler kullanılmıştır. İşletme sahiplerinin büyük oranda (%94.9) kolostrum kullandığı ve kolostrumun iki gün veya daha fazla süre ile verildiği tespit edilmiştir. Kovadan veya biberonla kolostrum veren işletmelerde çoğunlukla ılık sıcaklıkta (15-30 oC) (%58) ve 6 litre verildiği (%36) bulunmuştur. Çalışmada işletmelerde görülen ishal vakası oranı %38.29 iken, ishal vakaları ile verilen kolostrum miktarı arasında istatistiksel olarak önemli bir ilişki bulunmuştur (p<0.05). Sonuç olarak buzağılamanın akabinde doğru zaman, miktar ve kalitede kolostrum verilmesinin önemi ve faydalarının yetiştiricilere kavratılmasıyla buzağı kayıplarının ve diğer problemlerin önüne geçilebileceği düşünülmektedir.
Samsun İli Tekkeköy İlçesinde Yetişen Ümitvar Muşmula Genotiplerinin Belirlenmesi
Authors: ÇAKIR Elif , ÖZTÜRK Ahmet
Published: December 2019

Bu araştırma 2017 ve 2018
yıllarında Samsun ili Tekkeköy (Türkiye) ilçesi mahallelerinde doğal olarak
yetişen muşmula (Mespilus germanica
L.) popülasyonu içerisinde ümitvar genotipleri belirlemek amacıyla
yürütülmüştür. Araştırmada 15 g ve üzeri meyve ağırlığına sahip genotipler
seçilmiştir. Çalışmada 33 genotip incelenmiştir. İncelenen genotiplerde meyve
ağırlığı, meyve eti oranı, toplam kuru madde miktarı, suda çözünebilir kuru
madde miktarı ve C vitamini miktarı dikkate alınarak ümitvar genotipleri
belirlemek amacıyla tartılı derecelendirme metodu kullanılmıştır. Araştırmanın
ilk yılında (2017) meyve ağırlığı 15.08-25.44 g, meyve hacmi 14.36-24.11 mL,
meyve eti oranı %78.63-92.41, toplam kuru madde miktarı %64.20-78.01, SÇKM
içeriği %8.4-17.6, titreedilebilir asitlik %0.50-0.98, C vitamini miktarı
9.60-40 mg 100 g-1; ikinci yılında (2018) ise meyve ağırlığı
15.13-22.15 g, meyve hacmi 15.51-23.05 mL, meyve eti oranı %74.03-94.45, toplam
kuru madde miktarı %67.25-.79.24, SÇKM içeriği % 6.8-15.9, titreedilebilir
asitlik %0.27-1.34, C vitamini miktarı 7.0-34.0 mg 100 g-1 arasında
değişmiştir. Çalışmada ‘Tartılı Derecelendirme’ sonucunda en yüksek puanı
alarak çok iyi grupta yer alan 4, 25, ve 5 nolu genotipler ümitvar olarak
belirlenmiştir.
¿Innovan las innovaciones? Un análisis de Conectar Igualdad y Aprender Conectados
Authors: Torres Martín
Published: December 2019

El debate sobre el impacto y las acciones esperadas en la escuela frente a las transformaciones generadas por las tecnologías digitales, es un “lugar común” para periodistas “especializados”, pedagogos, docentes e investigadores. De allí se generan publicaciones, discursos y política pública para alcanzar la innovación educativa. Sin embargo, innovación puede significar cosas diferentes, según desde la(s) perspectiva(s) que se la proponga y/o analice. El presente artículo presenta un análisis del Programa Conectar Igualdad (PCI) y su heredero el Programa Aprender Conectados (PAC). Se consideran tres aspectos, su encuadre en ambos programas y el posible impacto limitante que tienen en las políticas públicas de innovación en educación. Para el análisis nos valdremos de aportes del pensamiento CTS, apostando a dar cuenta de su relevancia para este tipo de estudios.
Integración e infraestructura en América del Sur. Aportes para el estudio del rol estratégico de la Hidrovía Paraguay-Paraná en la integración regional
Authors: Álvaro Álvarez
Published: December 2019

En las últimas décadas un aspecto central en la discusión sobre la integración regional es el lugar preponderante otorgado a la integración en infraestructura, en compatibilidad con la implementación en la región de modelos de inserción en la economía internacional reprimarizados (Bolinaga & Slipak, 2015) que necesitan la reconversión de los corredores existentes en relación a las nuevas dinámicas de circulación.

En este contexto y, siendo la multimodalidad la característica más significativa del transporte internacional, las vías fluviales recobran importancia central como una forma de disminuir costos de circulación y como un factor clave en la integración de los territorios.

Este trabajo centrará su análisis en el rol geopolítico y comercialmente estratégico de la Hidrovía Paraguay-Paraná y en las obras de infraestructura planificadas y en desarrollo sobre los ríos Paraguay y Paraná en las últimas décadas. Para ello se utilizará una metodología de investigación multiescalar (García, 2006) y de triangulación (Bericat, 1998) combinando el análisis de fuentes y documentos oficiales de instituciones como CEPAL, CAF, BID, IIRSA-COSIPLAN con entrevistas a informantes claves. 

La discusión nodal emergente es qué infraestructura se promueve y financia en la región y para qué tipo de integración, en un contexto de debate paradigmático
Promoting Curriculum of Orgullo: Latinx’s Children’s Books and Testimonio
Authors: Calderon-Berumen Freyca , O'Donald Karla
Published: December 2019

As educators that are committed to democratic liberatory education for all, we are called to create spaces and places where we can cultivate and curate experiences that can provide avenues for students to develop self-awareness and agency. These dialogical spaces and places will problematize and question students’ knowledge and understanding leading them to articulate perspectives inhibited by hidden curriculum that hinders them from developing and actualizing a sense of self and purpose. This essay provides an example of decolonizing curriculum through children’s literature to support students in exploring, analyzing, and creating testimonies as a way to problematize their understandings and experiences with marginalized communities. Testimonio, embodied in the aesthetics of children’s literature, provides a pivotal pedagogical tool that allows students to critically reflect on systematic oppression, social inequalities, and hegemonic practices. Framed within a curriculum of orgullo (Calderon-Berumen & O’Donald, 2017), the testimonies embedded in children’s literature scaffolds the process of reading, producing, and analyzing students’ personal narratives.
Comparación de tres estrategias de enseñanza para el aprendizaje del átomo en estudiantes de educación media
Authors: Dussán Díaz Benjamín
Published: December 2019

Para identificar cuál estrategia didáctica permite una mejor comprensión del concepto átomo en estudiantes de primer grado de educación media se lle­vó una investigación controlada, comparando clase magistral; modelos físicos tridimensionales; y, las tecnologías de la información y la comunicación. In all five laboratory sections, students used the molecular imaging program, Protein Explorer (PE). Para tal fin, los estudiantes fueron aleatoriamente organizados en los siguientes grupos: grupo GT para la clase tradicional (basado en la lectura del libro guía), grupo GFT para los modelos físicos tridimensionales (elaborados con materiales de fácil adquisición) y GTIC para las tecnologías de la informa­ción y la comunicación (específicamente la herramienta web 2.0).

Para identificar cuál estrategia didáctica permite una mejor comprensión del concepto átomo en estudiantes de primer grado de educación media se lle­vó una investigación controlada, comparando clase magistral; modelos físicos tridimensionales; y, las tecnologías de la información y la comunicación. In all five laboratory sections, students used the molecular imaging program, Protein Explorer (PE). Para tal fin, los estudiantes fueron aleatoriamente organizados en los siguientes grupos: grupo GT para la clase tradicional (basado en la lectura del libro guía), grupo GFT para los modelos físicos tridimensionales (elaborados con materiales de fácil adquisición) y GTIC para las tecnologías de la informa­ción y la comunicación (específicamente la herramienta web 2.0).

El aprendizaje del estudiante se valoró a través Differences between the ex­perimental and control group students were not found in our typical course assessments such as research papers, but rather were revealed during one-on- one interviews with students at the end of the semester.de una evaluación con 12 preguntas, relacionadas con el tema, elaboradas y clasificadas con base en la taxonomía cognitiva de Bloom; estos resultados fueron analizados estadística­mente, encontrando que las respuestas provenientes de los estudiantes perte­necientes al grupo GFT presentaron una mayor cantidad de respuestas acerta­das; le siguió el grupo GTIC y finalmente el grupo GT. Esta investigación sugiere que el uso de modelos físicos tridimensionales, elaborados con materiales de fácil adquisición, se presenta como una estrategia útil de enseñanza que per­mite una mejor comprensión de los estudiantes en relación al tema del átomo.
Hacia una caracterización curricular en Cuba
Authors: Cuéllar Santos Juan Carlos
Published: December 2019

En el marco de la caracterización curricular en América Latina, es necesario enunciar la educación cubana como un referente de fuerte impacto, teniendo en cuenta sus altos logros a pesar de contar con múltiples dificultades de orden político y económico, en relación con las formas hegemónicas de la sociedad actual y por asumir una postura particular como alternativa de cosmovisión del contexto latinoamericano y del pueblo cubano. Sin embargo, el reconocimiento de la calidad educativa del pueblo cubano se ve reflejada de algún modo en las pruebas PISA promovidas por la UNESCO y adelantadas en el año 2006, donde dejan de manifiesto la solidez de la isla en el plano educativo; acontecimiento que según Martín Carnoy, Profesor de Educación y Economía en la Universidad de Stanford, quien ha venido estudiando los aspectos educativos de Cuba, determina que este aspecto obedece a que "las clases cubanas eran bien pensadas, los maestros cubanos bien entrenados y las escuelas cubanas responsablemente administradas"[1] En este mismo orden, el Gobierno de la República de Cuba confiere una importancia vertebral a la plena realización del derecho a la educación de sus ciudadanos; configurando desde sus primeros días un sistema educativo, referido "como una de las primeras prioridades en el desarrollo de políticas y programas, la superación de los obstáculos estructurales e institucionales al pleno disfrute de este derecho en el país. Una de las primeras medidas revolucionarias fue la erradicación del analfabetismo y la creación de las condiciones para garantizar la educación universal y gratuita en todos los niveles de enseñanza, lo cual hoy es una realidad".
EFEITOS MACROECONÔMICOS DA DEFESA COMERCIAL NO BRASIL
Authors: Mazzucco Bruno De Lorenzi Cancelier , Bittencourt Mauricio Vaz Lobo
Published: December 2019

Medidas protecionistas são geralmente adotadas com uma retórica de crescimento. Com esta justificativa, o Brasil vem intensificando o uso de medidas de proteção comercial desde o início da crise mundial em 2009. Neste artigo, são estimados os efeitos de uma forma particular de proteção, a defesa comercial, sobre variáveis macroeconômicas. Uma série de investigações antidumping de frequência trimestral e mensal é construída, e através de metodologia de séries temporais, avaliado o impacto macroeconômico de um aumento de novas investigações. Os resultados mostram que investigações antidumping têm um efeito no produto, mas não na inflação e no saldo da balança comercial. Estes resultados mostram que medidas protecionistas são recessivas até no curto prazo.
Developing a list of important drug- drug interactions in the clinical practice in the internal department – Kien An Hospital, Hai Phong City
Authors: Hanh Nguyen Thi , Thi Phuong Thao Vu , Quang Tuan Ha , Xuan Bach Nguyen , Thanh Hai Nguyen
Published: December 2019

This study was aimed to develop a list of important drug- drug interactions (DDIs) at the Internal department – Kien An Hospital. Subjects and methods: This study was 3 phases: (1) The construction of the initiative list was based on consenous of the documentations from the list of drugs in Kien An hospital: Micromedex 2.0, the patient leaflets and Drug Interaction Fact 2014. (2) The research group reviewed all the in-patient medical records in the General internal department and Cardiology department and sorted the high-frequency DDIs with prevalance higher than 1%. (3) After the DDIs of the first list and the second list were assessed by a group of doctors and pharmacists who the proposed a list of important DDIs at the internal deparment – Kien An Hospital. Results: From the documentations, the research group constructed 27 DDIs of the list. Conclusion: This DDIs list can be disseminated in clinical departments and integrated into the prescribing software of Kien An hospital.

Keywords

Kien An hospital, DDIs, Micromedex 2.0, high-frequency.

References

[1] D.C. Malone, J. Abarca, P.D. Hansten, A.J. Grizzle, E.P. Armstrong, R.C.V Bergen, B.S. Duncan-Edgar, S.L. Solomon, R.B. Lipton, Indentification of Serious Drug-Drug Interactions: Results of the Partnership to Prevent Drug-Drug Interactions, J. Am. Pharm. Assoc. 44 (2004) 142-151. https://doi.org/10.1331/154434504773062591.[2] P. Vonbach, A. Dubied, S. Kra¨henbu¨hl, J.H. Beer, Evaluation of frequently used drug interaction screening programs, Pharm. World. Sci. 30 (2008) 367-374. https://doi.org/10.1007/s11096-008-9191-x. [3] A.J. Harman, S.J. Press, Collecting and Analyzing Expert Group Judgement Data, Rand Corporation, Califonia, 1975.[4] P.E. Shrout, J.L. Fleiss, Intraclass Correlations: Uses in Assessing Rater Reliability, Psychol Bull. 86 (1979) 420-442. https://doi.org/10.1037//0033-2909.86.2.420. [5] D.S. Tatro, Drug Interaction Facts, Wolters Kluwer Health, 2014.[6] J. Abarca, D.C. Malone, E.P. Armstrong, A.J. Grizzle, P.D. Hansten, R.C.V. Bergen, R.B. Lipton, Concordance of Severity Ratings Provided in Four Drug Interaction Compendia, J. Am. Pharm. Assoc. 44 (2004) 136-141. https://doi.org/10.1331/154434504773062582. [7] N.T. Hang, P.T. Ha, N.M. Hoa, T.T. Ngan, N.H, Anh, N.T.H. Ha, Developing a list of clinically significant drug-drug interactions at the National Hospital of Pediatrics, Journal of Pharmaceutical reseach and Drug information 4+5 (2016) 137-141 (in Vietnamese). [8] Pharmacy Times, Diuretics, ACEIs, ARBs and NSAIDs: A Nephrotoxic Combination. https://www.pharmacytimes.com/publications/issue/2013/april2013/diuretics-aceis-arbs-and-nsaids-a-nephrotoxic-combination (accessed 18 April 2013).
Regulasi Konflik Pemilu (Studi Kasus Resolusi Konflik Pilkada 2015 dan Persiapan Pemilu 2019 di Kabupaten Sijunjung)
Authors: Anggraini Sri , Afrizal Afrizal , Indradin Indradin
Published: December 2019

In the election, the conflict will always exist. Whether it is a conflict between the election participants, between the participants and the election organizers or among the election organizers itself. The purpose of this research is to analyze the contribution of the Election Conflict Regulation on handling the election conflict in Sijunjung Regency and to analyze the response of the conflicting parties to the usage of the Election Conflict Regulation in Sijunjung District. This research used a qualitative approach with a case study plan. To see this problem, the researcher used Ralf Dahrendorf's Conflict Theory of Regulation which explains that conflict regulation can affect the high and low escalation of conflicts that occurred. The results showed that in the resolution of conflicts that had occurred both in the 2015 Regional Heads Election conflict or the conflict during the preparation of the 2019 General Election, researcher found that the General Election Conflict Regulation played a role / contributed in resolving the conflicts, where the conflicts could be controlled and resolved properly without any increase in violence. This was proven by the conflicting parties that accepted the decision given by the authorities in its settlement plus there were no other conflicting actors involved in the conflict.
Social Network Analysis in the Coastal Area Improvement Initiation Program
Authors: Novelisa Ayu
Published: December 2019

The research location is in Bungin Village, Pantai Bakti Village, where the issue is related to the conditions of coastal areas and brings up the program initiation. The research method was carried out with qualitative methods through in-depth interviews and participant observant. This thesis shows that in responding to the initiating improvements program in coastal areas, coastal communities are often faced with the social dynamics of the community itself. The response gap of the actors is influenced by social relations namely, 1) relations based on patron-client, 2) relations based on blood relations, and 3) relations based on emotional relationships, and two economic motives, namely 1) economic motives based on personal gain, and 2) economic motives which are based on basic needs. This thesis also enriches the study of the response of the fishing community through the approach of actor and network analysis. This approach is more relevant in looking at the response to the initiation of improving coastal areas through forms of actions, relationships, roles and motives of actors who are part of coastal communities.
Molecular serotyping and identification of the 85M gragment in different Colombian isolates of Listeria monocytogenes strains: A descriptive study
Authors: Vanegas María Consuelo , Medrano Mayra Viviana , Martínez Aida Juliana , Arévalo Stefany Alejandra
Published: December 2019

Introduction: Listeria monocytogenes is a pathogen acquired through the consumption of contaminated foods.Thirteen serotypes have been reported, of which 1/2a, 1/2b, and 4b are responsible for 98% of human listeriosis cases.This study examines the association between serotypes and virulent clones, offering greater information and providing tools to prevent and control diseases caused by L. monocytogenes serotype 4b.Objective: To identify the serotypes from L. monocytogene strains isolated from different samples by performing the molecular subtyping technique; to determine the 85M fragment that codifies for epidemic clone I.Methods : 108 strains of L. monocytogenes were used, isolated from samples of animals, body fluids, foods, and food processing plant equipment and spaces. The samples were identified by following the Bacteriological Analytical Manual protocol described by the Food and Drug Administration (FDA). The strains were identified by Polymerase Chain Reaction (PCR) using primers and a standardized protocol from a previous research project. Serotype identification was performed by multiplex PCR. The determination of the 85M fragment of the SSCS cassette was done by following the protocol by Yildrim et al.Results : Of the 108 L. monocytogenes strains analyzed, 60.2% (65 strains) belonged to the 4b-4d-4e serotype, 17.6% (19 strains) were identified as 1/2a-3a serotype, 14.8% (16 strains) were 4a-4c serotype, 3.7% (4 strains) belonged to the 1/2c-3c serotype, and (3.7%) corresponded to the 1/2b-3b-7 serotype. It was determined that the L. monocytogenesstrains serotype 4b-4d-4e and 1/2a-3b have the 85M fragment of the SSCS cassette.Conclusion : This study reports the predominant existence of L. monocytogenes strains serotype 4b-4d-4e in food, environmental, and clinical samples. The presence of an epidemic clone I region was also found in L. monocytogenes strains.
Assessment of growth and maturation status in pediatric patients and their clinical significance
Authors: González Emilio , Aguilar María José
Published: December 2019

Growth and development are two physiological organic processes by which living beings increase their mass and morphologically mature; thereby, acquiring full functional capacity. Given that growth in the human species shows a discontinuous rate, that is, alternating periods of rapid growth or acceleration phases of deceleration phases, the study in the pediatric population will be complex, requiring the use of mathematical models and reference standards. The aim of this study was to conduct a review on the main models and methods to analyze the growth curve during childhood and the most important reference standards to consider and evaluate growth parameters.
Molecular half-full mechanisms by phagocityc cells on invasive Aspergilosis
Authors: Dzul-Rosado Karla Rossanet , Martínez-Campos Viridiana , Peniche-Lara Gaspar , Zavala-Castro Jorge E
Published: December 2019

Fungus from the Aspergillus genus mainly affects lung tissue, occurring when the integrity of the host immune system is compromised. The human body uses immunocompetence conditions from mechanical and enzymatic defenses and the action of the innate immune system cells and also uses adaptive responses to control infection. Neutrophils, macrophages, and dendritic cells are critical as antifungal effector cells possess surface receptors that recognize fungal structures and trigger specific responses. TLRs and Dectin-1 the most studied for this interaction. TLRs are responsible for the production and release of cytokines and Dectin-1 is essential in the phagocytosis of the particle recognition and production of ROS. The best-studied cytokines and its crucial role in the response to Aspergillus spp. are TNF-α, IFN-γ, and IL-12. In this work, we reviewed the main mechanisms related to molecular receptors on phagocytic cells involved in the recognition of Aspergillus spp. Understanding the immune response in situations of  immunocompetence and its comparison in immunodeficient organisms could provide alternatives to control invasive aspergillosis.
Correspondence
Authors: Pachajoa Harry
Published: December 2019

Recently, Valencia et al., published a very interesting article called «Lipid profile in a group of patients with Turner's syndrome at Clínica Universitaria Bolivariana in the city of Medellín between 2000 and 2009"1. An article which evaluated lipid levels in patients with Turner syndrome in a Colombian clinic, the study associated results of lipid profile with karyotype and other risk factors for coronary heart disease.Because of the importance of the article and the prevalence of Turner syndrome (1 in 2,000 live-born women), it is important to have assessed the relationship with glycaemia and diabetes, when it is clearly recognized that this association exists and may be related to alterations of lipid, body mass index and mortality in these patients2. Although the article mentioned discusses the relationship between Turner syndrome and insulin resistance, it is important to know that a high risk for diabetes type 2 has been demonstrated among women with Turner syndrome, especially those with an isochromosome Xq, and it has been proposed that haploinsufficiency for Xp gene(s) causes the basic deficit in â-cell function seen in 45,X patients and that excess dosage of Xq genes exacerbates the deficit; perhaps by altering other genes involved in â-cell development and function or survival3. Therefore, it is necessary as it was in the article to analyze the laboratory results with those of karyotyping. Additionally, the results of the karyotypes need to be expressed by following the updated nomenclature of the International Standing Committee on Human Cytogenetics (2009)4.Finally, it is important for these patients to receive, as part of their management, genetic screening and genetic counseling where there are protocols defined for monitoring and evaluating other co-morbidities (renal anomalies, cardiac, dental, neurocognitive deficits and behavioral problems, among others) and not only of cardiovascular risk factors.
Remembering Dr. Alberto Pradilla Ferreira
Authors: De Onís Mercedes , Gracia Beatriz
Published: December 2019

Brilliant, simple, reserved, supportive friend, enthusiastic colleague, tireless worker, teacher. Adjectives that shelter the memory of someone who left an important legacy for public health, pediatrics and teaching in public health, focused mainly on nutrition. Doctor and Surgeon at the National University of Colombia (1956), Dr. Alberto Pradilla was one of the few Colombian doctors who, in addition to his medical specialty as a pediatrician, was trained in the area of ​​nutrition.
Breast intracystic papillary carcinoma with areas of infiltration. Report of two casesion: Report on two cases
Authors: Muñoz Diaz María del Mar , Martín Gutiérrez Silvia , Nieto Gallo María Antonia , Noguero Meseguera Rosario , Rodríguez Prieto Ignacio
Published: December 2019

Intracystic papillary carcinoma of the breast, associated with areas of infiltration, is rare, constituting less than 1% ofbreast cancers.
These are tumors whose initial radiological study shows lesions with low suspicion of malignancy in a high proportion of cases.We present two cases of intracystic papillary carcinoma, associated with infiltration diagnosed at the Breast Unit of Hospital Infanta CristinaIn both cases, the reason for consultation was the palpation of a nodule and the initial radiographic approach showed lesions with low suspicion of malignancy
Should we stop using the determination of central venous pressure as a way to estimate cardiac preload?
Authors: Ceron Arias Johann Smith , Muñoz Nañez Manuel Felipe
Published: December 2019

The determination of the values of central venous pressure has long been used as a guideline for volumetric therapy in the resuscitation of the critical patient, but the performance of such parameter is currently being questioned as an effective measurement of cardiac preload. This has aroused great interest in the search for more accurate parameters to determine cardiac preload and a patient’s blood volume. Goals and Methodology: Based on literature currently available, we aim to discuss the performance of central venous pressure as an effective parameter to determine cardiac preload. Results and Conclusion: Estimating variables such as end-diastolic ventricular area and global end-diastolic volume have a better performance than central venous pressure in determining cardiac preload. Despite the best performance of these devices, central venous pressure is still considered in our setting as the most practical and most commonly available way to assess the patient’s preload. Only dynamic variables such as pulse pressure change are superior in determining an individual’s blood volume.